id sid tid token lemma pos cord-005453-4057qib7 1 1 key key JJ cord-005453-4057qib7 1 2 : : : cord-005453-4057qib7 1 3 cord-005453 cord-005453 NNP cord-005453-4057qib7 1 4 - - HYPH cord-005453-4057qib7 1 5 4057qib7 4057qib7 CD cord-005453-4057qib7 1 6 authors author NNS cord-005453-4057qib7 1 7 : : : cord-005453-4057qib7 2 1 nan nan NNP cord-005453-4057qib7 2 2 title title NN cord-005453-4057qib7 2 3 : : : cord-005453-4057qib7 2 4 The the DT cord-005453-4057qib7 2 5 45th 45th JJ cord-005453-4057qib7 2 6 Annual Annual NNP cord-005453-4057qib7 2 7 Meeting Meeting NNP cord-005453-4057qib7 2 8 of of IN cord-005453-4057qib7 2 9 the the DT cord-005453-4057qib7 2 10 European European NNP cord-005453-4057qib7 2 11 Society Society NNP cord-005453-4057qib7 2 12 for for IN cord-005453-4057qib7 2 13 Blood blood NN cord-005453-4057qib7 2 14 and and CC cord-005453-4057qib7 2 15 Marrow marrow NN cord-005453-4057qib7 2 16 Transplantation transplantation NN cord-005453-4057qib7 2 17 : : : cord-005453-4057qib7 2 18 Physicians physician NNS cord-005453-4057qib7 2 19 – – : cord-005453-4057qib7 2 20 Poster poster NN cord-005453-4057qib7 2 21 Session Session NNP cord-005453-4057qib7 2 22 date date NN cord-005453-4057qib7 2 23 : : : cord-005453-4057qib7 2 24 2019 2019 CD cord-005453-4057qib7 2 25 - - HYPH cord-005453-4057qib7 2 26 07 07 CD cord-005453-4057qib7 2 27 - - HYPH cord-005453-4057qib7 2 28 03 03 CD cord-005453-4057qib7 2 29 journal journal NN cord-005453-4057qib7 2 30 : : : cord-005453-4057qib7 3 1 Bone Bone NNP cord-005453-4057qib7 3 2 Marrow marrow NN cord-005453-4057qib7 3 3 Transplant transplant NN cord-005453-4057qib7 3 4 DOI doi NN cord-005453-4057qib7 3 5 : : : cord-005453-4057qib7 3 6 10.1038 10.1038 CD cord-005453-4057qib7 3 7 / / SYM cord-005453-4057qib7 3 8 s41409 s41409 JJ cord-005453-4057qib7 3 9 - - HYPH cord-005453-4057qib7 3 10 019 019 CD cord-005453-4057qib7 3 11 - - HYPH cord-005453-4057qib7 3 12 0559 0559 CD cord-005453-4057qib7 3 13 - - SYM cord-005453-4057qib7 3 14 4 4 CD cord-005453-4057qib7 3 15 sha sha NNP cord-005453-4057qib7 3 16 : : : cord-005453-4057qib7 4 1 913db7c5d4ab48567de0304fdcc1f1b343d98aa1 913db7c5d4ab48567de0304fdcc1f1b343d98aa1 CD cord-005453-4057qib7 4 2 doc_id doc_id CD cord-005453-4057qib7 4 3 : : : cord-005453-4057qib7 4 4 5453 5453 CD cord-005453-4057qib7 4 5 cord_uid cord_uid FW cord-005453-4057qib7 4 6 : : : cord-005453-4057qib7 5 1 4057qib7 4057qib7 . cord-005453-4057qib7 6 1 nan nan NNP cord-005453-4057qib7 6 2 Background Background NNP cord-005453-4057qib7 6 3 : : : cord-005453-4057qib7 7 1 Allogeneic allogeneic IN cord-005453-4057qib7 7 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 7 3 stem stem NN cord-005453-4057qib7 7 4 cell cell NN cord-005453-4057qib7 7 5 transplantation transplantation NN cord-005453-4057qib7 7 6 is be VBZ cord-005453-4057qib7 7 7 routinely routinely RB cord-005453-4057qib7 7 8 offered offer VBN cord-005453-4057qib7 7 9 to to IN cord-005453-4057qib7 7 10 patients patient NNS cord-005453-4057qib7 7 11 with with IN cord-005453-4057qib7 7 12 high high JJ cord-005453-4057qib7 7 13 - - HYPH cord-005453-4057qib7 7 14 risk risk NN cord-005453-4057qib7 7 15 or or CC cord-005453-4057qib7 7 16 advanced advance VBD cord-005453-4057qib7 7 17 ALL all DT cord-005453-4057qib7 7 18 in in IN cord-005453-4057qib7 7 19 the the DT cord-005453-4057qib7 7 20 hopes hope NNS cord-005453-4057qib7 7 21 of of IN cord-005453-4057qib7 7 22 improving improve VBG cord-005453-4057qib7 7 23 outcomes outcome NNS cord-005453-4057qib7 7 24 . . . cord-005453-4057qib7 8 1 Use Use NNP cord-005453-4057qib7 8 2 of of IN cord-005453-4057qib7 8 3 truly truly RB cord-005453-4057qib7 8 4 non non JJ cord-005453-4057qib7 8 5 - - JJ cord-005453-4057qib7 8 6 myeloablative myeloablative JJ cord-005453-4057qib7 8 7 ( ( -LRB- cord-005453-4057qib7 8 8 NMA NMA NNP cord-005453-4057qib7 8 9 ) ) -RRB- cord-005453-4057qib7 8 10 conditioning conditioning NN cord-005453-4057qib7 8 11 reduces reduce VBZ cord-005453-4057qib7 8 12 toxicity toxicity NN cord-005453-4057qib7 8 13 in in IN cord-005453-4057qib7 8 14 other other JJ cord-005453-4057qib7 8 15 contexts context NNS cord-005453-4057qib7 8 16 but but CC cord-005453-4057qib7 8 17 outcome outcome NN cord-005453-4057qib7 8 18 data datum NNS cord-005453-4057qib7 8 19 for for IN cord-005453-4057qib7 8 20 ALL all DT cord-005453-4057qib7 8 21 patients patient NNS cord-005453-4057qib7 8 22 after after IN cord-005453-4057qib7 8 23 NMA NMA NNP cord-005453-4057qib7 8 24 transplants transplant NNS cord-005453-4057qib7 8 25 is be VBZ cord-005453-4057qib7 8 26 lacking lack VBG cord-005453-4057qib7 8 27 . . . cord-005453-4057qib7 9 1 We -PRON- PRP cord-005453-4057qib7 9 2 report report VBP cord-005453-4057qib7 9 3 the the DT cord-005453-4057qib7 9 4 outcomes outcome NNS cord-005453-4057qib7 9 5 of of IN cord-005453-4057qib7 9 6 31 31 CD cord-005453-4057qib7 9 7 patients patient NNS cord-005453-4057qib7 9 8 with with IN cord-005453-4057qib7 9 9 ALL all DT cord-005453-4057qib7 9 10 transplanted transplanted JJ cord-005453-4057qib7 9 11 using use VBG cord-005453-4057qib7 9 12 a a DT cord-005453-4057qib7 9 13 NMA NMA NNP cord-005453-4057qib7 9 14 conditioning conditioning NN cord-005453-4057qib7 9 15 without without IN cord-005453-4057qib7 9 16 T t NN cord-005453-4057qib7 9 17 cell cell NN cord-005453-4057qib7 9 18 depletion depletion NN cord-005453-4057qib7 9 19 . . . cord-005453-4057qib7 10 1 Methods method NNS cord-005453-4057qib7 10 2 : : : cord-005453-4057qib7 10 3 First first JJ cord-005453-4057qib7 10 4 transplant transplant NN cord-005453-4057qib7 10 5 patients patient NNS cord-005453-4057qib7 10 6 between between IN cord-005453-4057qib7 10 7 October October NNP cord-005453-4057qib7 10 8 2006 2006 CD cord-005453-4057qib7 10 9 and and CC cord-005453-4057qib7 10 10 June June NNP cord-005453-4057qib7 10 11 2018 2018 CD cord-005453-4057qib7 10 12 were be VBD cord-005453-4057qib7 10 13 reviewed review VBN cord-005453-4057qib7 10 14 . . . cord-005453-4057qib7 11 1 These these DT cord-005453-4057qib7 11 2 were be VBD cord-005453-4057qib7 11 3 consecutive consecutive JJ cord-005453-4057qib7 11 4 patients patient NNS cord-005453-4057qib7 11 5 until until IN cord-005453-4057qib7 11 6 2015 2015 CD cord-005453-4057qib7 11 7 then then RB cord-005453-4057qib7 11 8 only only RB cord-005453-4057qib7 11 9 those those DT cord-005453-4057qib7 11 10 considered consider VBN cord-005453-4057qib7 11 11 unfit unfit JJ cord-005453-4057qib7 11 12 for for IN cord-005453-4057qib7 11 13 FMC FMC NNP cord-005453-4057qib7 11 14 conditioning conditioning NN cord-005453-4057qib7 11 15 as as IN cord-005453-4057qib7 11 16 per per IN cord-005453-4057qib7 11 17 the the DT cord-005453-4057qib7 11 18 UKALL UKALL NNP cord-005453-4057qib7 11 19 2014 2014 CD cord-005453-4057qib7 11 20 protocol protocol NN cord-005453-4057qib7 11 21 . . . cord-005453-4057qib7 12 1 All all DT cord-005453-4057qib7 12 2 patients patient NNS cord-005453-4057qib7 12 3 were be VBD cord-005453-4057qib7 12 4 conditioned condition VBN cord-005453-4057qib7 12 5 with with IN cord-005453-4057qib7 12 6 fludarabine fludarabine NN cord-005453-4057qib7 12 7 25mg 25mg NNP cord-005453-4057qib7 12 8 / / SYM cord-005453-4057qib7 12 9 m m CD cord-005453-4057qib7 12 10 2 2 CD cord-005453-4057qib7 12 11 /day /day . cord-005453-4057qib7 12 12 for for IN cord-005453-4057qib7 12 13 5 5 CD cord-005453-4057qib7 12 14 days day NNS cord-005453-4057qib7 12 15 and and CC cord-005453-4057qib7 12 16 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12 17 1g 1g CD cord-005453-4057qib7 12 18 / / SYM cord-005453-4057qib7 12 19 m m NN cord-005453-4057qib7 12 20 2 2 CD cord-005453-4057qib7 12 21 /day /day . cord-005453-4057qib7 12 22 for for IN cord-005453-4057qib7 12 23 2 2 CD cord-005453-4057qib7 12 24 days day NNS cord-005453-4057qib7 12 25 . . . cord-005453-4057qib7 13 1 Short short JJ cord-005453-4057qib7 13 2 course course NN cord-005453-4057qib7 13 3 MTX MTX NNP cord-005453-4057qib7 13 4 and and CC cord-005453-4057qib7 13 5 ciclosporin ciclosporin NN cord-005453-4057qib7 13 6 were be VBD cord-005453-4057qib7 13 7 used use VBN cord-005453-4057qib7 13 8 for for IN cord-005453-4057qib7 13 9 GVHD GVHD NNP cord-005453-4057qib7 13 10 prophylaxis prophylaxis NN cord-005453-4057qib7 13 11 . . . cord-005453-4057qib7 14 1 Standard standard JJ cord-005453-4057qib7 14 2 supportive supportive JJ cord-005453-4057qib7 14 3 care care NN cord-005453-4057qib7 14 4 was be VBD cord-005453-4057qib7 14 5 employed employ VBN cord-005453-4057qib7 14 6 . . . cord-005453-4057qib7 15 1 Thirty thirty CD cord-005453-4057qib7 15 2 - - HYPH cord-005453-4057qib7 15 3 one one CD cord-005453-4057qib7 15 4 patients patient NNS cord-005453-4057qib7 15 5 with with IN cord-005453-4057qib7 15 6 a a DT cord-005453-4057qib7 15 7 median median JJ cord-005453-4057qib7 15 8 age age NN cord-005453-4057qib7 15 9 of of IN cord-005453-4057qib7 15 10 43 43 CD cord-005453-4057qib7 15 11 ( ( -LRB- cord-005453-4057qib7 15 12 23 23 CD cord-005453-4057qib7 15 13 - - SYM cord-005453-4057qib7 15 14 67 67 CD cord-005453-4057qib7 15 15 ) ) -RRB- cord-005453-4057qib7 15 16 met meet VBD cord-005453-4057qib7 15 17 the the DT cord-005453-4057qib7 15 18 criteria criterion NNS cord-005453-4057qib7 15 19 for for IN cord-005453-4057qib7 15 20 this this DT cord-005453-4057qib7 15 21 case case NN cord-005453-4057qib7 15 22 review review NN cord-005453-4057qib7 15 23 . . . cord-005453-4057qib7 16 1 30 30 CD cord-005453-4057qib7 16 2 had have VBD cord-005453-4057qib7 16 3 B b NN cord-005453-4057qib7 16 4 - - HYPH cord-005453-4057qib7 16 5 ALL all DT cord-005453-4057qib7 16 6 and and CC cord-005453-4057qib7 16 7 10 10 CD cord-005453-4057qib7 16 8 were be VBD cord-005453-4057qib7 16 9 Philadelphia Philadelphia NNP cord-005453-4057qib7 16 10 chromosome chromosome NN cord-005453-4057qib7 16 11 positive positive JJ cord-005453-4057qib7 16 12 . . . cord-005453-4057qib7 17 1 24 24 CD cord-005453-4057qib7 17 2 patients patient NNS cord-005453-4057qib7 17 3 ( ( -LRB- cord-005453-4057qib7 17 4 77 77 CD cord-005453-4057qib7 17 5 % % NN cord-005453-4057qib7 17 6 ) ) -RRB- cord-005453-4057qib7 17 7 had have VBD cord-005453-4057qib7 17 8 high high JJ cord-005453-4057qib7 17 9 risk risk NN cord-005453-4057qib7 17 10 disease disease NN cord-005453-4057qib7 17 11 by by IN cord-005453-4057qib7 17 12 standard standard JJ cord-005453-4057qib7 17 13 diagnostic diagnostic JJ cord-005453-4057qib7 17 14 criteria criterion NNS cord-005453-4057qib7 17 15 . . . cord-005453-4057qib7 18 1 27 27 CD cord-005453-4057qib7 18 2 ( ( -LRB- cord-005453-4057qib7 18 3 87 87 CD cord-005453-4057qib7 18 4 % % NN cord-005453-4057qib7 18 5 ) ) -RRB- cord-005453-4057qib7 18 6 were be VBD cord-005453-4057qib7 18 7 in in IN cord-005453-4057qib7 18 8 first first JJ cord-005453-4057qib7 18 9 complete complete JJ cord-005453-4057qib7 18 10 remission remission NN cord-005453-4057qib7 18 11 ( ( -LRB- cord-005453-4057qib7 18 12 CR1 CR1 NNP cord-005453-4057qib7 18 13 ) ) -RRB- cord-005453-4057qib7 18 14 . . . cord-005453-4057qib7 19 1 Matched matched JJ cord-005453-4057qib7 19 2 sibling sibling NN cord-005453-4057qib7 19 3 donors donor NNS cord-005453-4057qib7 19 4 were be VBD cord-005453-4057qib7 19 5 used use VBN cord-005453-4057qib7 19 6 in in IN cord-005453-4057qib7 19 7 13 13 CD cord-005453-4057qib7 19 8 instances instance NNS cord-005453-4057qib7 19 9 with with IN cord-005453-4057qib7 19 10 the the DT cord-005453-4057qib7 19 11 remaining remain VBG cord-005453-4057qib7 19 12 being be VBG cord-005453-4057qib7 19 13 fully fully RB cord-005453-4057qib7 19 14 matched match VBN cord-005453-4057qib7 19 15 unrelated unrelated JJ cord-005453-4057qib7 19 16 donors donor NNS cord-005453-4057qib7 19 17 . . . cord-005453-4057qib7 20 1 58 58 CD cord-005453-4057qib7 20 2 % % NN cord-005453-4057qib7 20 3 of of IN cord-005453-4057qib7 20 4 patients patient NNS cord-005453-4057qib7 20 5 had have VBD cord-005453-4057qib7 20 6 a a DT cord-005453-4057qib7 20 7 HCT HCT NNP cord-005453-4057qib7 20 8 - - HYPH cord-005453-4057qib7 20 9 CI ci NN cord-005453-4057qib7 20 10 score score NN cord-005453-4057qib7 20 11 of of IN cord-005453-4057qib7 20 12 0 0 CD cord-005453-4057qib7 20 13 , , , cord-005453-4057qib7 20 14 32 32 CD cord-005453-4057qib7 20 15 % % NN cord-005453-4057qib7 20 16 a a DT cord-005453-4057qib7 20 17 score score NN cord-005453-4057qib7 20 18 of of IN cord-005453-4057qib7 20 19 1 1 CD cord-005453-4057qib7 20 20 or or CC cord-005453-4057qib7 20 21 2 2 CD cord-005453-4057qib7 20 22 with with IN cord-005453-4057qib7 20 23 3 3 CD cord-005453-4057qib7 20 24 patients patient NNS cord-005453-4057qib7 20 25 having have VBG cord-005453-4057qib7 20 26 a a DT cord-005453-4057qib7 20 27 score score NN cord-005453-4057qib7 20 28 of of IN cord-005453-4057qib7 20 29 3 3 CD cord-005453-4057qib7 20 30 or or CC cord-005453-4057qib7 20 31 higher high JJR cord-005453-4057qib7 20 32 . . . cord-005453-4057qib7 21 1 Median median JJ cord-005453-4057qib7 21 2 CD34 CD34 NNP cord-005453-4057qib7 21 3 dose dose NN cord-005453-4057qib7 21 4 was be VBD cord-005453-4057qib7 21 5 5.3 5.3 CD cord-005453-4057qib7 21 6 x x SYM cord-005453-4057qib7 21 7 10 10 CD cord-005453-4057qib7 21 8 6 6 CD cord-005453-4057qib7 21 9 /kg /kg . cord-005453-4057qib7 21 10 ( ( -LRB- cord-005453-4057qib7 21 11 0.93 0.93 CD cord-005453-4057qib7 21 12 - - SYM cord-005453-4057qib7 21 13 34.12 34.12 CD cord-005453-4057qib7 21 14 ) ) -RRB- cord-005453-4057qib7 21 15 with with IN cord-005453-4057qib7 21 16 a a DT cord-005453-4057qib7 21 17 median median JJ cord-005453-4057qib7 21 18 CD3 CD3 NNP cord-005453-4057qib7 21 19 dose dose NN cord-005453-4057qib7 21 20 of of IN cord-005453-4057qib7 21 21 2.13 2.13 CD cord-005453-4057qib7 21 22 x x SYM cord-005453-4057qib7 21 23 10 10 CD cord-005453-4057qib7 21 24 8 8 CD cord-005453-4057qib7 21 25 / / SYM cord-005453-4057qib7 21 26 kg kg NN cord-005453-4057qib7 21 27 ( ( -LRB- cord-005453-4057qib7 21 28 0.12 0.12 CD cord-005453-4057qib7 21 29 - - SYM cord-005453-4057qib7 21 30 7.37 7.37 CD cord-005453-4057qib7 21 31 ) ) -RRB- cord-005453-4057qib7 21 32 Results result NNS cord-005453-4057qib7 21 33 : : : cord-005453-4057qib7 22 1 TRM TRM NNP cord-005453-4057qib7 22 2 was be VBD cord-005453-4057qib7 22 3 low low JJ cord-005453-4057qib7 22 4 at at IN cord-005453-4057qib7 22 5 7 7 CD cord-005453-4057qib7 22 6 % % NN cord-005453-4057qib7 22 7 at at IN cord-005453-4057qib7 22 8 1 1 CD cord-005453-4057qib7 22 9 year year NN cord-005453-4057qib7 22 10 and and CC cord-005453-4057qib7 22 11 11 11 CD cord-005453-4057qib7 22 12 % % NN cord-005453-4057qib7 22 13 at at IN cord-005453-4057qib7 22 14 2 2 CD cord-005453-4057qib7 22 15 and and CC cord-005453-4057qib7 22 16 3 3 CD cord-005453-4057qib7 22 17 years year NNS cord-005453-4057qib7 22 18 respectively respectively RB cord-005453-4057qib7 22 19 . . . cord-005453-4057qib7 23 1 No no DT cord-005453-4057qib7 23 2 factors factor NNS cord-005453-4057qib7 23 3 included include VBN cord-005453-4057qib7 23 4 in in IN cord-005453-4057qib7 23 5 a a DT cord-005453-4057qib7 23 6 univariate univariate JJ cord-005453-4057qib7 23 7 analysis analysis NN cord-005453-4057qib7 23 8 ( ( -LRB- cord-005453-4057qib7 23 9 which which WDT cord-005453-4057qib7 23 10 included include VBD cord-005453-4057qib7 23 11 age age NN cord-005453-4057qib7 23 12 , , , cord-005453-4057qib7 23 13 diagnosis diagnosis NN cord-005453-4057qib7 23 14 , , , cord-005453-4057qib7 23 15 disease disease NN cord-005453-4057qib7 23 16 status status NN cord-005453-4057qib7 23 17 , , , cord-005453-4057qib7 23 18 HCT HCT NNP cord-005453-4057qib7 23 19 - - HYPH cord-005453-4057qib7 23 20 CI ci NN cord-005453-4057qib7 23 21 , , , cord-005453-4057qib7 23 22 donor donor NN cord-005453-4057qib7 23 23 type type NN cord-005453-4057qib7 23 24 , , , cord-005453-4057qib7 23 25 CMV CMV NNP cord-005453-4057qib7 23 26 risk risk NN cord-005453-4057qib7 23 27 and and CC cord-005453-4057qib7 23 28 cell cell NN cord-005453-4057qib7 23 29 dose dose NN cord-005453-4057qib7 23 30 ) ) -RRB- cord-005453-4057qib7 23 31 significantly significantly RB cord-005453-4057qib7 23 32 impacted impact VBD cord-005453-4057qib7 23 33 TRM TRM NNP cord-005453-4057qib7 23 34 . . . cord-005453-4057qib7 24 1 The the DT cord-005453-4057qib7 24 2 incidence incidence NN cord-005453-4057qib7 24 3 of of IN cord-005453-4057qib7 24 4 classical classical JJ cord-005453-4057qib7 24 5 acute acute NN cord-005453-4057qib7 24 6 ( ( -LRB- cord-005453-4057qib7 24 7 a a DT cord-005453-4057qib7 24 8 ) ) -RRB- cord-005453-4057qib7 24 9 GVHD gvhd JJ cord-005453-4057qib7 24 10 grade grade NN cord-005453-4057qib7 24 11 2 2 CD cord-005453-4057qib7 24 12 - - SYM cord-005453-4057qib7 24 13 4 4 CD cord-005453-4057qib7 24 14 and and CC cord-005453-4057qib7 24 15 3 3 CD cord-005453-4057qib7 24 16 - - SYM cord-005453-4057qib7 24 17 4 4 CD cord-005453-4057qib7 24 18 was be VBD cord-005453-4057qib7 24 19 18 18 CD cord-005453-4057qib7 24 20 % % NN cord-005453-4057qib7 24 21 and and CC cord-005453-4057qib7 24 22 8 8 CD cord-005453-4057qib7 24 23 % % NN cord-005453-4057qib7 24 24 by by IN cord-005453-4057qib7 24 25 day day NN cord-005453-4057qib7 24 26 100 100 CD cord-005453-4057qib7 24 27 and and CC cord-005453-4057qib7 24 28 29 29 CD cord-005453-4057qib7 24 29 % % NN cord-005453-4057qib7 24 30 and and CC cord-005453-4057qib7 24 31 13 13 CD cord-005453-4057qib7 24 32 % % NN cord-005453-4057qib7 24 33 by by IN cord-005453-4057qib7 24 34 day day NN cord-005453-4057qib7 24 35 180 180 CD cord-005453-4057qib7 24 36 if if IN cord-005453-4057qib7 24 37 late late JJ cord-005453-4057qib7 24 38 onset onset NN cord-005453-4057qib7 24 39 aGVHD aGVHD NNP cord-005453-4057qib7 24 40 is be VBZ cord-005453-4057qib7 24 41 included include VBN cord-005453-4057qib7 24 42 . . . cord-005453-4057qib7 25 1 24 24 CD cord-005453-4057qib7 25 2 out out IN cord-005453-4057qib7 25 3 of of IN cord-005453-4057qib7 25 4 30 30 CD cord-005453-4057qib7 25 5 eligible eligible JJ cord-005453-4057qib7 25 6 patients patient NNS cord-005453-4057qib7 25 7 developed develop VBD cord-005453-4057qib7 25 8 chronic chronic JJ cord-005453-4057qib7 25 9 GVHD GVHD NNP cord-005453-4057qib7 25 10 of of IN cord-005453-4057qib7 25 11 any any DT cord-005453-4057qib7 25 12 stage stage NN cord-005453-4057qib7 25 13 . . . cord-005453-4057qib7 26 1 Relapse relapse NN cord-005453-4057qib7 26 2 incidence incidence NN cord-005453-4057qib7 26 3 was be VBD cord-005453-4057qib7 26 4 low low JJ cord-005453-4057qib7 26 5 ( ( -LRB- cord-005453-4057qib7 26 6 22 22 CD cord-005453-4057qib7 26 7 % % NN cord-005453-4057qib7 26 8 at at IN cord-005453-4057qib7 26 9 3 3 CD cord-005453-4057qib7 26 10 years year NNS cord-005453-4057qib7 26 11 in in IN cord-005453-4057qib7 26 12 all all DT cord-005453-4057qib7 26 13 patients patient NNS cord-005453-4057qib7 26 14 , , , cord-005453-4057qib7 26 15 17 17 CD cord-005453-4057qib7 26 16 % % NN cord-005453-4057qib7 26 17 in in IN cord-005453-4057qib7 26 18 CR1 CR1 NNP cord-005453-4057qib7 26 19 patients patient NNS cord-005453-4057qib7 26 20 ) ) -RRB- cord-005453-4057qib7 26 21 and and CC cord-005453-4057qib7 26 22 was be VBD cord-005453-4057qib7 26 23 not not RB cord-005453-4057qib7 26 24 impacted impact VBN cord-005453-4057qib7 26 25 by by IN cord-005453-4057qib7 26 26 any any DT cord-005453-4057qib7 26 27 pre pre JJ cord-005453-4057qib7 26 28 - - JJ cord-005453-4057qib7 26 29 transplant transplant JJ cord-005453-4057qib7 26 30 factors factor NNS cord-005453-4057qib7 26 31 including include VBG cord-005453-4057qib7 26 32 positive positive JJ cord-005453-4057qib7 26 33 MRD MRD NNP cord-005453-4057qib7 26 34 post post NN cord-005453-4057qib7 26 35 phase phase NN cord-005453-4057qib7 26 36 2 2 CD cord-005453-4057qib7 26 37 induction induction NN cord-005453-4057qib7 26 38 ( ( -LRB- cord-005453-4057qib7 26 39 present present JJ cord-005453-4057qib7 26 40 in in IN cord-005453-4057qib7 26 41 6 6 CD cord-005453-4057qib7 26 42 patients patient NNS cord-005453-4057qib7 26 43 ) ) -RRB- cord-005453-4057qib7 26 44 . . . cord-005453-4057qib7 27 1 Notably notably RB cord-005453-4057qib7 27 2 , , , cord-005453-4057qib7 27 3 in in IN cord-005453-4057qib7 27 4 univariate univariate JJ cord-005453-4057qib7 27 5 analysis analysis NN cord-005453-4057qib7 27 6 relapse relapse NN cord-005453-4057qib7 27 7 was be VBD cord-005453-4057qib7 27 8 significantly significantly RB cord-005453-4057qib7 27 9 lower low JJR cord-005453-4057qib7 27 10 in in IN cord-005453-4057qib7 27 11 patients patient NNS cord-005453-4057qib7 27 12 who who WP cord-005453-4057qib7 27 13 developed develop VBD cord-005453-4057qib7 27 14 chronic chronic JJ cord-005453-4057qib7 27 15 GvHD GvHD NNP cord-005453-4057qib7 27 16 . . . cord-005453-4057qib7 28 1 Background background NN cord-005453-4057qib7 28 2 : : : cord-005453-4057qib7 29 1 Allogeneic allogeneic IN cord-005453-4057qib7 29 2 stem stem VBP cord-005453-4057qib7 29 3 cell cell NN cord-005453-4057qib7 29 4 transplantation transplantation NN cord-005453-4057qib7 29 5 ( ( -LRB- cord-005453-4057qib7 29 6 alloSCT alloSCT NNP cord-005453-4057qib7 29 7 ) ) -RRB- cord-005453-4057qib7 29 8 is be VBZ cord-005453-4057qib7 29 9 the the DT cord-005453-4057qib7 29 10 treatment treatment NN cord-005453-4057qib7 29 11 of of IN cord-005453-4057qib7 29 12 choice choice NN cord-005453-4057qib7 29 13 for for IN cord-005453-4057qib7 29 14 many many JJ cord-005453-4057qib7 29 15 patients patient NNS cord-005453-4057qib7 29 16 ( ( -LRB- cord-005453-4057qib7 29 17 pts pts NN cord-005453-4057qib7 29 18 ) ) -RRB- cord-005453-4057qib7 29 19 suffering suffer VBG cord-005453-4057qib7 29 20 from from IN cord-005453-4057qib7 29 21 acute acute JJ cord-005453-4057qib7 29 22 myeloid myeloid NN cord-005453-4057qib7 29 23 leukemia leukemia NN cord-005453-4057qib7 29 24 ( ( -LRB- cord-005453-4057qib7 29 25 AML AML NNP cord-005453-4057qib7 29 26 ) ) -RRB- cord-005453-4057qib7 29 27 . . . cord-005453-4057qib7 30 1 The the DT cord-005453-4057qib7 30 2 graft graft NN cord-005453-4057qib7 30 3 vs. vs. FW cord-005453-4057qib7 30 4 leukemia leukemia NN cord-005453-4057qib7 30 5 effect effect NN cord-005453-4057qib7 30 6 ( ( -LRB- cord-005453-4057qib7 30 7 GvL gvl NN cord-005453-4057qib7 30 8 ) ) -RRB- cord-005453-4057qib7 30 9 , , , cord-005453-4057qib7 30 10 applied apply VBN cord-005453-4057qib7 30 11 by by IN cord-005453-4057qib7 30 12 immunocompetent immunocompetent JJ cord-005453-4057qib7 30 13 cells cell NNS cord-005453-4057qib7 30 14 of of IN cord-005453-4057qib7 30 15 donor donor NN cord-005453-4057qib7 30 16 origin origin NN cord-005453-4057qib7 30 17 , , , cord-005453-4057qib7 30 18 is be VBZ cord-005453-4057qib7 30 19 the the DT cord-005453-4057qib7 30 20 most most RBS cord-005453-4057qib7 30 21 important important JJ cord-005453-4057qib7 30 22 effector effector NN cord-005453-4057qib7 30 23 mechanism mechanism NN cord-005453-4057qib7 30 24 for for IN cord-005453-4057qib7 30 25 the the DT cord-005453-4057qib7 30 26 eradication eradication NN cord-005453-4057qib7 30 27 of of IN cord-005453-4057qib7 30 28 leukemia leukemia NN cord-005453-4057qib7 30 29 , , , cord-005453-4057qib7 30 30 The the DT cord-005453-4057qib7 30 31 presentation presentation NN cord-005453-4057qib7 30 32 of of IN cord-005453-4057qib7 30 33 leukemic leukemic JJ cord-005453-4057qib7 30 34 or or CC cord-005453-4057qib7 30 35 allospecific allospecific NN cord-005453-4057qib7 30 36 antigens antigen NNS cord-005453-4057qib7 30 37 by by IN cord-005453-4057qib7 30 38 malignant malignant JJ cord-005453-4057qib7 30 39 blasts blast NNS cord-005453-4057qib7 30 40 is be VBZ cord-005453-4057qib7 30 41 regarded regard VBN cord-005453-4057qib7 30 42 as as IN cord-005453-4057qib7 30 43 a a DT cord-005453-4057qib7 30 44 crucial crucial JJ cord-005453-4057qib7 30 45 trigger trigger NN cord-005453-4057qib7 30 46 for for IN cord-005453-4057qib7 30 47 an an DT cord-005453-4057qib7 30 48 effective effective JJ cord-005453-4057qib7 30 49 allogeneic allogeneic NN cord-005453-4057qib7 30 50 immune immune JJ cord-005453-4057qib7 30 51 response response NN cord-005453-4057qib7 30 52 . . . cord-005453-4057qib7 31 1 Conversely conversely RB cord-005453-4057qib7 31 2 , , , cord-005453-4057qib7 31 3 insufficient insufficient JJ cord-005453-4057qib7 31 4 stimulatory stimulatory JJ cord-005453-4057qib7 31 5 capacity capacity NN cord-005453-4057qib7 31 6 by by IN cord-005453-4057qib7 31 7 the the DT cord-005453-4057qib7 31 8 leukemic leukemic JJ cord-005453-4057qib7 31 9 blasts blast NNS cord-005453-4057qib7 31 10 is be VBZ cord-005453-4057qib7 31 11 thought think VBN cord-005453-4057qib7 31 12 to to TO cord-005453-4057qib7 31 13 be be VB cord-005453-4057qib7 31 14 a a DT cord-005453-4057qib7 31 15 relevant relevant JJ cord-005453-4057qib7 31 16 escape escape NN cord-005453-4057qib7 31 17 mechanism mechanism NN cord-005453-4057qib7 31 18 from from IN cord-005453-4057qib7 31 19 cellular cellular JJ cord-005453-4057qib7 31 20 immunotherapy immunotherapy NN cord-005453-4057qib7 31 21 ( ( -LRB- cord-005453-4057qib7 31 22 alloSCT alloSCT NNP cord-005453-4057qib7 31 23 or or CC cord-005453-4057qib7 31 24 donor donor NN cord-005453-4057qib7 31 25 - - HYPH cord-005453-4057qib7 31 26 lymphocyte lymphocyte NN cord-005453-4057qib7 31 27 infusion infusion NN cord-005453-4057qib7 31 28 ( ( -LRB- cord-005453-4057qib7 31 29 DLI DLI NNP cord-005453-4057qib7 31 30 ) ) -RRB- cord-005453-4057qib7 31 31 ) ) -RRB- cord-005453-4057qib7 31 32 . . . cord-005453-4057qib7 32 1 The the DT cord-005453-4057qib7 32 2 purpose purpose NN cord-005453-4057qib7 32 3 was be VBD cord-005453-4057qib7 32 4 to to TO cord-005453-4057qib7 32 5 test test VB cord-005453-4057qib7 32 6 , , , cord-005453-4057qib7 32 7 whether whether IN cord-005453-4057qib7 32 8 the the DT cord-005453-4057qib7 32 9 ability ability NN cord-005453-4057qib7 32 10 of of IN cord-005453-4057qib7 32 11 malignant malignant JJ cord-005453-4057qib7 32 12 blasts blast NNS cord-005453-4057qib7 32 13 to to TO cord-005453-4057qib7 32 14 differentiate differentiate VB cord-005453-4057qib7 32 15 in in IN cord-005453-4057qib7 32 16 vitro vitro FW cord-005453-4057qib7 32 17 towards towards IN cord-005453-4057qib7 32 18 dendritic dendritic JJ cord-005453-4057qib7 32 19 cells cell NNS cord-005453-4057qib7 32 20 of of IN cord-005453-4057qib7 32 21 leukemic leukemic JJ cord-005453-4057qib7 32 22 origin origin NN cord-005453-4057qib7 32 23 ( ( -LRB- cord-005453-4057qib7 32 24 DC DC NNP cord-005453-4057qib7 32 25 leu leu NNP cord-005453-4057qib7 32 26 ) ) -RRB- cord-005453-4057qib7 32 27 is be VBZ cord-005453-4057qib7 32 28 associated associate VBN cord-005453-4057qib7 32 29 with with IN cord-005453-4057qib7 32 30 response response NN cord-005453-4057qib7 32 31 to to IN cord-005453-4057qib7 32 32 alloSCT alloSCT NNP cord-005453-4057qib7 32 33 or or CC cord-005453-4057qib7 32 34 outcome outcome NN cord-005453-4057qib7 32 35 after after IN cord-005453-4057qib7 32 36 immunotherapy immunotherapy NN cord-005453-4057qib7 32 37 ( ( -LRB- cord-005453-4057qib7 32 38 second second JJ cord-005453-4057qib7 32 39 alloSCT alloSCT NNP cord-005453-4057qib7 32 40 or or CC cord-005453-4057qib7 32 41 DLI DLI NNP cord-005453-4057qib7 32 42 ) ) -RRB- cord-005453-4057qib7 32 43 for for IN cord-005453-4057qib7 32 44 post post JJ cord-005453-4057qib7 32 45 - - JJ cord-005453-4057qib7 32 46 transplant transplant JJ cord-005453-4057qib7 32 47 relapse relapse NN cord-005453-4057qib7 32 48 in in IN cord-005453-4057qib7 32 49 AML AML NNP cord-005453-4057qib7 32 50 . . . cord-005453-4057qib7 33 1 Methods method NNS cord-005453-4057qib7 33 2 : : : cord-005453-4057qib7 34 1 Leukemic leukemic JJ cord-005453-4057qib7 34 2 blasts blast NNS cord-005453-4057qib7 34 3 were be VBD cord-005453-4057qib7 34 4 isolated isolate VBN cord-005453-4057qib7 34 5 from from IN cord-005453-4057qib7 34 6 peripheral peripheral JJ cord-005453-4057qib7 34 7 blood blood NN cord-005453-4057qib7 34 8 ( ( -LRB- cord-005453-4057qib7 34 9 PB PB NNP cord-005453-4057qib7 34 10 ) ) -RRB- cord-005453-4057qib7 34 11 or or CC cord-005453-4057qib7 34 12 bone bone NN cord-005453-4057qib7 34 13 marrow marrow NN cord-005453-4057qib7 34 14 ( ( -LRB- cord-005453-4057qib7 34 15 BM BM NNP cord-005453-4057qib7 34 16 ) ) -RRB- cord-005453-4057qib7 34 17 samples sample NNS cord-005453-4057qib7 34 18 of of IN cord-005453-4057qib7 34 19 AML AML NNP cord-005453-4057qib7 34 20 patients patient NNS cord-005453-4057qib7 34 21 before before IN cord-005453-4057qib7 34 22 alloSCT alloSCT NNP cord-005453-4057qib7 34 23 ( ( -LRB- cord-005453-4057qib7 34 24 n=47 n=47 NN cord-005453-4057qib7 34 25 ) ) -RRB- cord-005453-4057qib7 34 26 or or CC cord-005453-4057qib7 34 27 at at IN cord-005453-4057qib7 34 28 relapse relapse NN cord-005453-4057qib7 34 29 after after IN cord-005453-4057qib7 34 30 alloSCT alloSCT NNP cord-005453-4057qib7 34 31 ( ( -LRB- cord-005453-4057qib7 34 32 n=22 n=22 NNP cord-005453-4057qib7 34 33 ) ) -RRB- cord-005453-4057qib7 34 34 . . . cord-005453-4057qib7 35 1 A a DT cord-005453-4057qib7 35 2 panel panel NN cord-005453-4057qib7 35 3 of of IN cord-005453-4057qib7 35 4 6 6 CD cord-005453-4057qib7 35 5 different different JJ cord-005453-4057qib7 35 6 assays assay NNS cord-005453-4057qib7 35 7 was be VBD cord-005453-4057qib7 35 8 used use VBN cord-005453-4057qib7 35 9 to to TO cord-005453-4057qib7 35 10 generate generate VB cord-005453-4057qib7 35 11 DC DC NNP cord-005453-4057qib7 35 12 leu leu NNP cord-005453-4057qib7 35 13 in in IN cord-005453-4057qib7 35 14 vitro vitro FW cord-005453-4057qib7 35 15 ( ( -LRB- cord-005453-4057qib7 35 16 5 5 CD cord-005453-4057qib7 35 17 of of IN cord-005453-4057qib7 35 18 them -PRON- PRP cord-005453-4057qib7 35 19 containing contain VBG cord-005453-4057qib7 35 20 GM GM NNP cord-005453-4057qib7 35 21 - - HYPH cord-005453-4057qib7 35 22 CSF CSF NNP cord-005453-4057qib7 35 23 ) ) -RRB- cord-005453-4057qib7 35 24 . . . cord-005453-4057qib7 36 1 Finally finally RB cord-005453-4057qib7 36 2 , , , cord-005453-4057qib7 36 3 in in IN cord-005453-4057qib7 36 4 vitro vitro FW cord-005453-4057qib7 36 5 results result NNS cord-005453-4057qib7 36 6 were be VBD cord-005453-4057qib7 36 7 correlated correlate VBN cord-005453-4057qib7 36 8 with with IN cord-005453-4057qib7 36 9 clinical clinical JJ cord-005453-4057qib7 36 10 characteristics characteristic NNS cord-005453-4057qib7 36 11 and and CC cord-005453-4057qib7 36 12 outcome outcome NN cord-005453-4057qib7 36 13 of of IN cord-005453-4057qib7 36 14 patients patient NNS cord-005453-4057qib7 36 15 treated treat VBN cord-005453-4057qib7 36 16 with with IN cord-005453-4057qib7 36 17 donor donor NN cord-005453-4057qib7 36 18 lymphocyte lymphocyte NN cord-005453-4057qib7 36 19 infusion infusion NN cord-005453-4057qib7 36 20 and/or and/or CC cord-005453-4057qib7 37 1 alloSCT alloSCT NNP cord-005453-4057qib7 37 2 . . . cord-005453-4057qib7 38 1 Results result NNS cord-005453-4057qib7 38 2 : : : cord-005453-4057qib7 39 1 DC DC NNP cord-005453-4057qib7 39 2 leu leu NNP cord-005453-4057qib7 39 3 could could MD cord-005453-4057qib7 39 4 be be VB cord-005453-4057qib7 39 5 generated generate VBN cord-005453-4057qib7 39 6 in in IN cord-005453-4057qib7 39 7 vitro vitro FW cord-005453-4057qib7 39 8 from from IN cord-005453-4057qib7 39 9 all all DT cord-005453-4057qib7 39 10 69 69 CD cord-005453-4057qib7 39 11 samples sample NNS cord-005453-4057qib7 39 12 . . . cord-005453-4057qib7 40 1 When when WRB cord-005453-4057qib7 40 2 correlating correlate VBG cord-005453-4057qib7 40 3 proportions proportion NNS cord-005453-4057qib7 40 4 of of IN cord-005453-4057qib7 40 5 DC DC NNP cord-005453-4057qib7 40 6 - - HYPH cord-005453-4057qib7 40 7 subtypes subtype NNS cord-005453-4057qib7 40 8 generated generate VBD cord-005453-4057qib7 40 9 ex ex FW cord-005453-4057qib7 40 10 vivo vivo FW cord-005453-4057qib7 40 11 with with IN cord-005453-4057qib7 40 12 clinical clinical JJ cord-005453-4057qib7 40 13 data datum NNS cord-005453-4057qib7 40 14 , , , cord-005453-4057qib7 40 15 significantly significantly RB cord-005453-4057qib7 40 16 higher high JJR cord-005453-4057qib7 40 17 mean mean JJ cord-005453-4057qib7 40 18 proportions proportion NNS cord-005453-4057qib7 40 19 of of IN cord-005453-4057qib7 40 20 DC DC NNP cord-005453-4057qib7 40 21 leu leu NNP cord-005453-4057qib7 40 22 in in IN cord-005453-4057qib7 40 23 the the DT cord-005453-4057qib7 40 24 DC DC NNP cord-005453-4057qib7 40 25 - - HYPH cord-005453-4057qib7 40 26 fraction fraction NN cord-005453-4057qib7 40 27 were be VBD cord-005453-4057qib7 40 28 found find VBN cord-005453-4057qib7 40 29 in in IN cord-005453-4057qib7 40 30 responders responder NNS cord-005453-4057qib7 40 31 vs. vs. IN cord-005453-4057qib7 40 32 non non NNS cord-005453-4057qib7 40 33 - - NNS cord-005453-4057qib7 40 34 responders responder NNS cord-005453-4057qib7 40 35 to to IN cord-005453-4057qib7 40 36 immunotherapy immunotherapy NN cord-005453-4057qib7 40 37 ( ( -LRB- cord-005453-4057qib7 40 38 76.8 76.8 CD cord-005453-4057qib7 40 39 % % NN cord-005453-4057qib7 40 40 vs vs IN cord-005453-4057qib7 40 41 58.8%,p=0.006 58.8%,p=0.006 CD cord-005453-4057qib7 40 42 , , , cord-005453-4057qib7 40 43 range:13%-99 range:13%-99 NNP cord-005453-4057qib7 40 44 % % NN cord-005453-4057qib7 40 45 ) ) -RRB- cord-005453-4057qib7 40 46 . . . cord-005453-4057qib7 41 1 Vice Vice NNP cord-005453-4057qib7 41 2 versa versa RB cord-005453-4057qib7 41 3 , , , cord-005453-4057qib7 41 4 the the DT cord-005453-4057qib7 41 5 chance chance NN cord-005453-4057qib7 41 6 for for IN cord-005453-4057qib7 41 7 response response NN cord-005453-4057qib7 41 8 to to IN cord-005453-4057qib7 41 9 immunotherapy immunotherapy NN cord-005453-4057qib7 41 10 was be VBD cord-005453-4057qib7 41 11 significantly significantly RB cord-005453-4057qib7 41 12 higher high JJR cord-005453-4057qib7 41 13 , , , cord-005453-4057qib7 41 14 if if IN cord-005453-4057qib7 41 15 a a DT cord-005453-4057qib7 41 16 DC DC NNP cord-005453-4057qib7 41 17 leu leu NNP cord-005453-4057qib7 41 18 /DC /DC : cord-005453-4057qib7 41 19 ratio ratio NN cord-005453-4057qib7 41 20 of of IN cord-005453-4057qib7 41 21 > > XX cord-005453-4057qib7 41 22 = = SYM cord-005453-4057qib7 41 23 50 50 CD cord-005453-4057qib7 41 24 % % NN cord-005453-4057qib7 41 25 could could MD cord-005453-4057qib7 41 26 be be VB cord-005453-4057qib7 41 27 reached reach VBN cord-005453-4057qib7 41 28 in in IN cord-005453-4057qib7 41 29 vivo vivo FW cord-005453-4057qib7 41 30 ( ( -LRB- cord-005453-4057qib7 41 31 p=0.004 p=0.004 NNP cord-005453-4057qib7 41 32 ) ) -RRB- cord-005453-4057qib7 41 33 . . . cord-005453-4057qib7 42 1 Those those DT cord-005453-4057qib7 42 2 patientswere patientswere RB cord-005453-4057qib7 42 3 characterized characterize VBN cord-005453-4057qib7 42 4 by by IN cord-005453-4057qib7 42 5 a a DT cord-005453-4057qib7 42 6 longer long JJR cord-005453-4057qib7 42 7 time time NN cord-005453-4057qib7 42 8 to to TO cord-005453-4057qib7 42 9 relapse relapse VB cord-005453-4057qib7 42 10 ( ( -LRB- cord-005453-4057qib7 42 11 p=0.04 p=0.04 NN cord-005453-4057qib7 42 12 ) ) -RRB- cord-005453-4057qib7 42 13 and and CC cord-005453-4057qib7 42 14 by by IN cord-005453-4057qib7 42 15 a a DT cord-005453-4057qib7 42 16 higher high JJR cord-005453-4057qib7 42 17 probability probability NN cord-005453-4057qib7 42 18 for for IN cord-005453-4057qib7 42 19 leukemia leukemia NN cord-005453-4057qib7 42 20 - - HYPH cord-005453-4057qib7 42 21 free free JJ cord-005453-4057qib7 42 22 survival survival NN cord-005453-4057qib7 42 23 ( ( -LRB- cord-005453-4057qib7 42 24 p=0.005 p=0.005 NNP cord-005453-4057qib7 42 25 ) ) -RRB- cord-005453-4057qib7 42 26 . . . cord-005453-4057qib7 43 1 Similarly similarly RB cord-005453-4057qib7 43 2 , , , cord-005453-4057qib7 43 3 generation generation NN cord-005453-4057qib7 43 4 of of IN cord-005453-4057qib7 43 5 higher high JJR cord-005453-4057qib7 43 6 amounts amount NNS cord-005453-4057qib7 43 7 ( ( -LRB- cord-005453-4057qib7 43 8 > > NFP cord-005453-4057qib7 43 9 8 8 CD cord-005453-4057qib7 43 10 % % NN cord-005453-4057qib7 43 11 , , , cord-005453-4057qib7 43 12 p=0.04 p=0.04 NNP cord-005453-4057qib7 43 13 ) ) -RRB- cord-005453-4057qib7 43 14 of of IN cord-005453-4057qib7 43 15 DC DC NNP cord-005453-4057qib7 43 16 leu leu NNP cord-005453-4057qib7 43 17 in in IN cord-005453-4057qib7 43 18 the the DT cord-005453-4057qib7 43 19 MNC MNC NNP cord-005453-4057qib7 43 20 - - HYPH cord-005453-4057qib7 43 21 fraction fraction NN cord-005453-4057qib7 43 22 , , , cord-005453-4057qib7 43 23 and and CC cord-005453-4057qib7 43 24 generation generation NN cord-005453-4057qib7 43 25 of of IN cord-005453-4057qib7 43 26 more more JJR cord-005453-4057qib7 43 27 mature mature JJ cord-005453-4057qib7 43 28 DC DC NNP cord-005453-4057qib7 43 29 ( ( -LRB- cord-005453-4057qib7 43 30 > > NFP cord-005453-4057qib7 43 31 47 47 CD cord-005453-4057qib7 43 32 % % NN cord-005453-4057qib7 44 1 CD83 CD83 NNP cord-005453-4057qib7 44 2 + + CC cord-005453-4057qib7 44 3 , , , cord-005453-4057qib7 44 4 p=0.03 p=0.03 NN cord-005453-4057qib7 44 5 using use VBG cord-005453-4057qib7 44 6 the the DT cord-005453-4057qib7 44 7 best good JJS cord-005453-4057qib7 44 8 GM GM NNP cord-005453-4057qib7 44 9 - - HYPH cord-005453-4057qib7 44 10 CSF CSF NNP cord-005453-4057qib7 44 11 containing contain VBG cord-005453-4057qib7 44 12 assay assay NN cord-005453-4057qib7 44 13 ) ) -RRB- cord-005453-4057qib7 44 14 were be VBD cord-005453-4057qib7 44 15 associated associate VBN cord-005453-4057qib7 44 16 with with IN cord-005453-4057qib7 44 17 a a DT cord-005453-4057qib7 44 18 longer long JJR cord-005453-4057qib7 44 19 time time NN cord-005453-4057qib7 44 20 to to TO cord-005453-4057qib7 44 21 relapse relapse VB cord-005453-4057qib7 44 22 in in IN cord-005453-4057qib7 44 23 the the DT cord-005453-4057qib7 44 24 respective respective JJ cord-005453-4057qib7 44 25 patients patient NNS cord-005453-4057qib7 44 26 . . . cord-005453-4057qib7 45 1 Moreover moreover RB cord-005453-4057qib7 45 2 , , , cord-005453-4057qib7 45 3 overall overall JJ cord-005453-4057qib7 45 4 survival survival NN cord-005453-4057qib7 45 5 was be VBD cord-005453-4057qib7 45 6 improved improve VBN cord-005453-4057qib7 45 7 , , , cord-005453-4057qib7 45 8 if if IN cord-005453-4057qib7 45 9 > > XX cord-005453-4057qib7 45 10 70 70 CD cord-005453-4057qib7 45 11 % % NN cord-005453-4057qib7 45 12 DC DC NNP cord-005453-4057qib7 45 13 leu leu NNP cord-005453-4057qib7 45 14 /DC /DC NNP cord-005453-4057qib7 45 15 could could MD cord-005453-4057qib7 45 16 be be VB cord-005453-4057qib7 45 17 generated generate VBN cord-005453-4057qib7 45 18 with with IN cord-005453-4057qib7 45 19 the the DT cord-005453-4057qib7 45 20 best good JJS cord-005453-4057qib7 45 21 GM GM NNP cord-005453-4057qib7 45 22 - - HYPH cord-005453-4057qib7 45 23 CSF CSF NNP cord-005453-4057qib7 45 24 containing contain VBG cord-005453-4057qib7 45 25 assay assay NN cord-005453-4057qib7 45 26 ( ( -LRB- cord-005453-4057qib7 45 27 p=0.048 p=0.048 NNP cord-005453-4057qib7 45 28 ) ) -RRB- cord-005453-4057qib7 45 29 . . . cord-005453-4057qib7 46 1 Conclusions conclusion NNS cord-005453-4057qib7 46 2 : : : cord-005453-4057qib7 47 1 In in IN cord-005453-4057qib7 47 2 vitro vitro FW cord-005453-4057qib7 47 3 generation generation NN cord-005453-4057qib7 47 4 of of IN cord-005453-4057qib7 47 5 DC DC NNP cord-005453-4057qib7 47 6 / / SYM cord-005453-4057qib7 47 7 DC DC NNP cord-005453-4057qib7 47 8 leu leu NNP cord-005453-4057qib7 47 9 from from IN cord-005453-4057qib7 47 10 leukemic leukemic JJ cord-005453-4057qib7 47 11 blasts blast NNS cord-005453-4057qib7 47 12 obtained obtain VBN cord-005453-4057qib7 47 13 in in IN cord-005453-4057qib7 47 14 active active JJ cord-005453-4057qib7 47 15 stages stage NNS cord-005453-4057qib7 47 16 of of IN cord-005453-4057qib7 47 17 AML AML NNP cord-005453-4057qib7 47 18 before before IN cord-005453-4057qib7 47 19 alloSCT alloSCT NNP cord-005453-4057qib7 47 20 or or CC cord-005453-4057qib7 47 21 at at IN cord-005453-4057qib7 47 22 relapse relapse NN cord-005453-4057qib7 47 23 post post NN cord-005453-4057qib7 47 24 transplant transplant NN cord-005453-4057qib7 47 25 were be VBD cord-005453-4057qib7 47 26 associated associate VBN cord-005453-4057qib7 47 27 with with IN cord-005453-4057qib7 47 28 clinical clinical JJ cord-005453-4057qib7 47 29 outcome outcome NN cord-005453-4057qib7 47 30 . . . cord-005453-4057qib7 48 1 This this DT cord-005453-4057qib7 48 2 observation observation NN cord-005453-4057qib7 48 3 supports support VBZ cord-005453-4057qib7 48 4 a a DT cord-005453-4057qib7 48 5 role role NN cord-005453-4057qib7 48 6 of of IN cord-005453-4057qib7 48 7 antigen antigen NN cord-005453-4057qib7 48 8 presentation presentation NN cord-005453-4057qib7 48 9 by by IN cord-005453-4057qib7 48 10 leukemic leukemic JJ cord-005453-4057qib7 48 11 cells cell NNS cord-005453-4057qib7 48 12 for for IN cord-005453-4057qib7 48 13 an an DT cord-005453-4057qib7 48 14 allogeneic allogeneic JJ cord-005453-4057qib7 48 15 immune immune JJ cord-005453-4057qib7 48 16 response response NN cord-005453-4057qib7 48 17 in in IN cord-005453-4057qib7 48 18 AML AML NNP cord-005453-4057qib7 48 19 . . . cord-005453-4057qib7 49 1 Disclosure disclosure NN cord-005453-4057qib7 49 2 : : : cord-005453-4057qib7 49 3 Nothing nothing NN cord-005453-4057qib7 49 4 to to TO cord-005453-4057qib7 49 5 declare declare VB cord-005453-4057qib7 49 6 Background background NN cord-005453-4057qib7 49 7 : : : cord-005453-4057qib7 50 1 The the DT cord-005453-4057qib7 50 2 role role NN cord-005453-4057qib7 50 3 of of IN cord-005453-4057qib7 50 4 autologous autologous JJ cord-005453-4057qib7 50 5 hematopoetic hematopoetic JJ cord-005453-4057qib7 50 6 cell cell NN cord-005453-4057qib7 50 7 transplantation transplantation NN cord-005453-4057qib7 50 8 ( ( -LRB- cord-005453-4057qib7 50 9 HCT HCT NNP cord-005453-4057qib7 50 10 ) ) -RRB- cord-005453-4057qib7 50 11 in in IN cord-005453-4057qib7 50 12 the the DT cord-005453-4057qib7 50 13 treatment treatment NN cord-005453-4057qib7 50 14 of of IN cord-005453-4057qib7 50 15 AML AML NNP cord-005453-4057qib7 50 16 is be VBZ cord-005453-4057qib7 50 17 not not RB cord-005453-4057qib7 50 18 clear clear JJ cord-005453-4057qib7 50 19 . . . cord-005453-4057qib7 51 1 Trials trial NNS cord-005453-4057qib7 51 2 in in IN cord-005453-4057qib7 51 3 the the DT cord-005453-4057qib7 51 4 past past NN cord-005453-4057qib7 51 5 have have VBP cord-005453-4057qib7 51 6 shown show VBN cord-005453-4057qib7 51 7 that that IN cord-005453-4057qib7 51 8 autologous autologous JJ cord-005453-4057qib7 51 9 HCT hct NN cord-005453-4057qib7 51 10 consolidation consolidation NN cord-005453-4057qib7 51 11 lowers lower VBZ cord-005453-4057qib7 51 12 the the DT cord-005453-4057qib7 51 13 risk risk NN cord-005453-4057qib7 51 14 of of IN cord-005453-4057qib7 51 15 relapse relapse NN cord-005453-4057qib7 51 16 , , , cord-005453-4057qib7 51 17 however however RB cord-005453-4057qib7 51 18 the the DT cord-005453-4057qib7 51 19 magnitude magnitude NN cord-005453-4057qib7 51 20 of of IN cord-005453-4057qib7 51 21 this this DT cord-005453-4057qib7 51 22 effect effect NN cord-005453-4057qib7 51 23 is be VBZ cord-005453-4057qib7 51 24 limited limit VBN cord-005453-4057qib7 51 25 . . . cord-005453-4057qib7 52 1 Autologous autologous JJ cord-005453-4057qib7 52 2 HCT HCT NNP cord-005453-4057qib7 52 3 is be VBZ cord-005453-4057qib7 52 4 advocated advocate VBN cord-005453-4057qib7 52 5 in in IN cord-005453-4057qib7 52 6 patients patient NNS cord-005453-4057qib7 52 7 with with IN cord-005453-4057qib7 52 8 AML AML NNP cord-005453-4057qib7 52 9 with with IN cord-005453-4057qib7 52 10 lower low JJR cord-005453-4057qib7 52 11 genetic genetic JJ cord-005453-4057qib7 52 12 risk risk NN cord-005453-4057qib7 52 13 in in IN cord-005453-4057qib7 52 14 CR1.Many CR1.Many NNP cord-005453-4057qib7 52 15 of of IN cord-005453-4057qib7 52 16 these these DT cord-005453-4057qib7 52 17 patients patient NNS cord-005453-4057qib7 52 18 will will MD cord-005453-4057qib7 52 19 eventually eventually RB cord-005453-4057qib7 52 20 relapse relapse VB cord-005453-4057qib7 52 21 and and CC cord-005453-4057qib7 52 22 will will MD cord-005453-4057qib7 52 23 undergo undergo VB cord-005453-4057qib7 52 24 reinduction reinduction NN cord-005453-4057qib7 52 25 followed follow VBN cord-005453-4057qib7 52 26 by by IN cord-005453-4057qib7 52 27 allogeneic allogeneic NN cord-005453-4057qib7 52 28 HCT hct NN cord-005453-4057qib7 52 29 in in IN cord-005453-4057qib7 52 30 CR2 CR2 NNP cord-005453-4057qib7 52 31 . . . cord-005453-4057qib7 53 1 Methods method NNS cord-005453-4057qib7 53 2 : : : cord-005453-4057qib7 54 1 The the DT cord-005453-4057qib7 54 2 aims aim NNS cord-005453-4057qib7 54 3 of of IN cord-005453-4057qib7 54 4 this this DT cord-005453-4057qib7 54 5 study study NN cord-005453-4057qib7 54 6 is be VBZ cord-005453-4057qib7 54 7 to to TO cord-005453-4057qib7 54 8 analyze analyze VB cord-005453-4057qib7 54 9 outcome outcome NN cord-005453-4057qib7 54 10 of of IN cord-005453-4057qib7 54 11 allogeneic allogeneic NN cord-005453-4057qib7 54 12 HCT HCT NNP cord-005453-4057qib7 54 13 performed perform VBN cord-005453-4057qib7 54 14 in in IN cord-005453-4057qib7 54 15 CR2 CR2 NNP cord-005453-4057qib7 54 16 comparing compare VBG cord-005453-4057qib7 54 17 patients patient NNS cord-005453-4057qib7 54 18 with with IN cord-005453-4057qib7 54 19 prior prior JJ cord-005453-4057qib7 54 20 consolidation consolidation NN cord-005453-4057qib7 54 21 by by IN cord-005453-4057qib7 54 22 autologous autologous JJ cord-005453-4057qib7 54 23 HCT hct NN cord-005453-4057qib7 54 24 vs. vs. IN cord-005453-4057qib7 54 25 patients patient NNS cord-005453-4057qib7 54 26 with with IN cord-005453-4057qib7 54 27 chemotherapy chemotherapy NN cord-005453-4057qib7 54 28 consolidation consolidation NN cord-005453-4057qib7 54 29 . . . cord-005453-4057qib7 55 1 Primary primary JJ cord-005453-4057qib7 55 2 outcome outcome NN cord-005453-4057qib7 55 3 is be VBZ cord-005453-4057qib7 55 4 Non non JJ cord-005453-4057qib7 55 5 relapse relapse NN cord-005453-4057qib7 55 6 mortality mortality NN cord-005453-4057qib7 55 7 ( ( -LRB- cord-005453-4057qib7 55 8 NRM NRM NNP cord-005453-4057qib7 55 9 ) ) -RRB- cord-005453-4057qib7 55 10 of of IN cord-005453-4057qib7 55 11 allogeneic allogeneic NN cord-005453-4057qib7 55 12 HCT hct NN cord-005453-4057qib7 55 13 in in IN cord-005453-4057qib7 55 14 CR2 CR2 NNP cord-005453-4057qib7 55 15 in in IN cord-005453-4057qib7 55 16 patients patient NNS cord-005453-4057qib7 55 17 with with IN cord-005453-4057qib7 55 18 , , , cord-005453-4057qib7 55 19 or or CC cord-005453-4057qib7 55 20 without without IN cord-005453-4057qib7 55 21 prior prior JJ cord-005453-4057qib7 55 22 autologous autologous JJ cord-005453-4057qib7 55 23 HCT hct NN cord-005453-4057qib7 55 24 in in IN cord-005453-4057qib7 55 25 CR1 CR1 NNP cord-005453-4057qib7 55 26 . . . cord-005453-4057qib7 56 1 Secondary secondary JJ cord-005453-4057qib7 56 2 outcomes outcome NNS cord-005453-4057qib7 56 3 include include VBP cord-005453-4057qib7 56 4 leukemia leukemia NN cord-005453-4057qib7 56 5 free free JJ cord-005453-4057qib7 56 6 survival survival NN cord-005453-4057qib7 56 7 ( ( -LRB- cord-005453-4057qib7 56 8 LFS LFS NNP cord-005453-4057qib7 56 9 ) ) -RRB- cord-005453-4057qib7 56 10 , , , cord-005453-4057qib7 56 11 relapse relapse NN cord-005453-4057qib7 56 12 rate rate NN cord-005453-4057qib7 56 13 ( ( -LRB- cord-005453-4057qib7 56 14 RI RI NNP cord-005453-4057qib7 56 15 ) ) -RRB- cord-005453-4057qib7 56 16 , , , cord-005453-4057qib7 56 17 graft graft NN cord-005453-4057qib7 56 18 versus versus IN cord-005453-4057qib7 56 19 host host NN cord-005453-4057qib7 56 20 disease disease NN cord-005453-4057qib7 56 21 free free JJ cord-005453-4057qib7 56 22 relapse relapse NN cord-005453-4057qib7 56 23 free free JJ cord-005453-4057qib7 56 24 survival survival NN cord-005453-4057qib7 56 25 ( ( -LRB- cord-005453-4057qib7 56 26 GRFS GRFS NNP cord-005453-4057qib7 56 27 ) ) -RRB- cord-005453-4057qib7 56 28 , , , cord-005453-4057qib7 56 29 overall overall JJ cord-005453-4057qib7 56 30 survival survival NN cord-005453-4057qib7 56 31 ( ( -LRB- cord-005453-4057qib7 56 32 OS OS NNP cord-005453-4057qib7 56 33 ) ) -RRB- cord-005453-4057qib7 56 34 , , , cord-005453-4057qib7 56 35 and and CC cord-005453-4057qib7 56 36 treatment treatment NN cord-005453-4057qib7 56 37 related relate VBN cord-005453-4057qib7 56 38 toxicities toxicity NNS cord-005453-4057qib7 56 39 . . . cord-005453-4057qib7 57 1 Results result NNS cord-005453-4057qib7 57 2 : : : cord-005453-4057qib7 58 1 2619 2619 CD cord-005453-4057qib7 58 2 adult adult NN cord-005453-4057qib7 58 3 patients patient NNS cord-005453-4057qib7 58 4 reigstered reigstere VBD cord-005453-4057qib7 58 5 with with IN cord-005453-4057qib7 58 6 the the DT cord-005453-4057qib7 58 7 ALWP ALWP NNP cord-005453-4057qib7 58 8 of of IN cord-005453-4057qib7 58 9 the the DT cord-005453-4057qib7 58 10 EBMT EBMT NNP cord-005453-4057qib7 58 11 with with IN cord-005453-4057qib7 58 12 de de NNP cord-005453-4057qib7 58 13 novo novo NNP cord-005453-4057qib7 58 14 AML AML NNP cord-005453-4057qib7 58 15 were be VBD cord-005453-4057qib7 58 16 included include VBN cord-005453-4057qib7 58 17 , , , cord-005453-4057qib7 58 18 receiving receive VBG cord-005453-4057qib7 58 19 a a DT cord-005453-4057qib7 58 20 first first JJ cord-005453-4057qib7 58 21 allogeneic allogeneic NN cord-005453-4057qib7 58 22 HCT hct NN cord-005453-4057qib7 58 23 in in IN cord-005453-4057qib7 58 24 CR2 CR2 NNP cord-005453-4057qib7 58 25 , , , cord-005453-4057qib7 58 26 in in IN cord-005453-4057qib7 58 27 2000 2000 CD cord-005453-4057qib7 58 28 CR2 CR2 NNP cord-005453-4057qib7 58 29 , , , cord-005453-4057qib7 58 30 in in IN cord-005453-4057qib7 58 31 -2017 -2017 : cord-005453-4057qib7 58 32 or or CC cord-005453-4057qib7 58 33 without without IN cord-005453-4057qib7 58 34 ( ( -LRB- cord-005453-4057qib7 58 35 n=2202 n=2202 CD cord-005453-4057qib7 58 36 ) ) -RRB- cord-005453-4057qib7 58 37 prior prior JJ cord-005453-4057qib7 58 38 autologous autologous JJ cord-005453-4057qib7 58 39 HCT hct NN cord-005453-4057qib7 58 40 . . . cord-005453-4057qib7 59 1 Patient patient JJ cord-005453-4057qib7 59 2 and and CC cord-005453-4057qib7 59 3 transplant transplant NN cord-005453-4057qib7 59 4 characteristics characteristic NNS cord-005453-4057qib7 59 5 are be VBP cord-005453-4057qib7 59 6 shown show VBN cord-005453-4057qib7 59 7 in in IN cord-005453-4057qib7 59 8 the the DT cord-005453-4057qib7 59 9 Table table NN cord-005453-4057qib7 59 10 . . . cord-005453-4057qib7 60 1 Patient patient JJ cord-005453-4057qib7 60 2 groups group NNS cord-005453-4057qib7 60 3 were be VBD cord-005453-4057qib7 60 4 not not RB cord-005453-4057qib7 60 5 entirely entirely RB cord-005453-4057qib7 60 6 comparable comparable JJ cord-005453-4057qib7 60 7 , , , cord-005453-4057qib7 60 8 patients patient NNS cord-005453-4057qib7 60 9 with with IN cord-005453-4057qib7 60 10 prior prior JJ cord-005453-4057qib7 60 11 autologous autologous JJ cord-005453-4057qib7 60 12 HCT HCT NNP cord-005453-4057qib7 60 13 were be VBD cord-005453-4057qib7 60 14 younger young JJR cord-005453-4057qib7 60 15 , , , cord-005453-4057qib7 60 16 had have VBD cord-005453-4057qib7 60 17 less less RBR cord-005453-4057qib7 60 18 often often RB cord-005453-4057qib7 60 19 a a DT cord-005453-4057qib7 60 20 favorable favorable JJ cord-005453-4057qib7 60 21 cytogenetic cytogenetic NN cord-005453-4057qib7 60 22 profile profile NN cord-005453-4057qib7 60 23 , , , cord-005453-4057qib7 60 24 had have VBD cord-005453-4057qib7 60 25 more more RBR cord-005453-4057qib7 60 26 commonly commonly RB cord-005453-4057qib7 60 27 donors donor NNS cord-005453-4057qib7 60 28 other other JJ cord-005453-4057qib7 60 29 than than IN cord-005453-4057qib7 60 30 matched matched JJ cord-005453-4057qib7 60 31 siblings sibling NNS cord-005453-4057qib7 60 32 and and CC cord-005453-4057qib7 60 33 more more RBR cord-005453-4057qib7 60 34 often often RB cord-005453-4057qib7 60 35 received receive VBN cord-005453-4057qib7 60 36 reduced reduced JJ cord-005453-4057qib7 60 37 intensity intensity NN cord-005453-4057qib7 60 38 conditioning conditioning NN cord-005453-4057qib7 60 39 ( ( -LRB- cord-005453-4057qib7 60 40 RIC RIC NNP cord-005453-4057qib7 60 41 ) ) -RRB- cord-005453-4057qib7 60 42 as as IN cord-005453-4057qib7 60 43 compared compare VBN cord-005453-4057qib7 60 44 to to IN cord-005453-4057qib7 60 45 MAC MAC NNP cord-005453-4057qib7 60 46 conditioning conditioning NN cord-005453-4057qib7 60 47 . . . cord-005453-4057qib7 61 1 Univariate univariate JJ cord-005453-4057qib7 61 2 outcomes outcome NNS cord-005453-4057qib7 61 3 are be VBP cord-005453-4057qib7 61 4 shown show VBN cord-005453-4057qib7 61 5 in in IN cord-005453-4057qib7 61 6 the the DT cord-005453-4057qib7 61 7 Table table NN cord-005453-4057qib7 61 8 with with IN cord-005453-4057qib7 61 9 slightly slightly RB cord-005453-4057qib7 61 10 higher high JJR cord-005453-4057qib7 61 11 NRM NRM NNP cord-005453-4057qib7 61 12 risks risk NNS cord-005453-4057qib7 61 13 in in IN cord-005453-4057qib7 61 14 patients patient NNS cord-005453-4057qib7 61 15 with with IN cord-005453-4057qib7 61 16 prior prior JJ cord-005453-4057qib7 61 17 autologous autologous JJ cord-005453-4057qib7 61 18 HCT hct NN cord-005453-4057qib7 61 19 consolidation consolidation NN cord-005453-4057qib7 61 20 . . . cord-005453-4057qib7 62 1 In in IN cord-005453-4057qib7 62 2 multivariate multivariate JJ cord-005453-4057qib7 62 3 analysis analysis NN cord-005453-4057qib7 62 4 NRM NRM NNP cord-005453-4057qib7 62 5 risks risk NNS cord-005453-4057qib7 62 6 in in IN cord-005453-4057qib7 62 7 patients patient NNS cord-005453-4057qib7 62 8 with with IN cord-005453-4057qib7 62 9 prior prior JJ cord-005453-4057qib7 62 10 autologous autologous JJ cord-005453-4057qib7 62 11 HCT HCT NNP cord-005453-4057qib7 62 12 were be VBD cord-005453-4057qib7 62 13 1.34 1.34 CD cord-005453-4057qib7 62 14 ( ( -LRB- cord-005453-4057qib7 62 15 1.07 1.07 CD cord-005453-4057qib7 62 16 - - SYM cord-005453-4057qib7 62 17 1.67 1.67 CD cord-005453-4057qib7 62 18 ) ) -RRB- cord-005453-4057qib7 62 19 , , , cord-005453-4057qib7 62 20 p=0.01 p=0.01 VBN cord-005453-4057qib7 62 21 after after IN cord-005453-4057qib7 62 22 adjustment adjustment NN cord-005453-4057qib7 62 23 for for IN cord-005453-4057qib7 62 24 patient patient JJ cord-005453-4057qib7 62 25 age age NN cord-005453-4057qib7 62 26 , , , cord-005453-4057qib7 62 27 cytogenetic cytogenetic JJ cord-005453-4057qib7 62 28 risk risk NN cord-005453-4057qib7 62 29 category category NN cord-005453-4057qib7 62 30 , , , cord-005453-4057qib7 62 31 year year NN cord-005453-4057qib7 62 32 of of IN cord-005453-4057qib7 62 33 transplant transplant NN cord-005453-4057qib7 62 34 , , , cord-005453-4057qib7 62 35 donor donor NN cord-005453-4057qib7 62 36 type type NN cord-005453-4057qib7 62 37 , , , cord-005453-4057qib7 62 38 conditioning conditioning NN cord-005453-4057qib7 62 39 intensity intensity NN cord-005453-4057qib7 62 40 , , , cord-005453-4057qib7 62 41 sex sex NN cord-005453-4057qib7 62 42 matching matching NN cord-005453-4057qib7 62 43 , , , cord-005453-4057qib7 62 44 time time NN cord-005453-4057qib7 62 45 from from IN cord-005453-4057qib7 62 46 diagnosis diagnosis NN cord-005453-4057qib7 62 47 to to IN cord-005453-4057qib7 62 48 relapse relapse NN cord-005453-4057qib7 62 49 and and CC cord-005453-4057qib7 62 50 time time NN cord-005453-4057qib7 62 51 from from IN cord-005453-4057qib7 62 52 relapse relapse NN cord-005453-4057qib7 62 53 to to IN cord-005453-4057qib7 62 54 allogeneic allogeneic NN cord-005453-4057qib7 62 55 HCT hct NN cord-005453-4057qib7 62 56 as as IN cord-005453-4057qib7 62 57 compared compare VBN cord-005453-4057qib7 62 58 to to IN cord-005453-4057qib7 62 59 patients patient NNS cord-005453-4057qib7 62 60 with with IN cord-005453-4057qib7 62 61 chemotherapy chemotherapy NN cord-005453-4057qib7 62 62 consolidation consolidation NN cord-005453-4057qib7 62 63 . . . cord-005453-4057qib7 63 1 Similarly similarly RB cord-005453-4057qib7 63 2 , , , cord-005453-4057qib7 63 3 risks risk NNS cord-005453-4057qib7 63 4 of of IN cord-005453-4057qib7 63 5 events event NNS cord-005453-4057qib7 63 6 in in IN cord-005453-4057qib7 63 7 LFS lfs NN cord-005453-4057qib7 63 8 and and CC cord-005453-4057qib7 63 9 GRFS GRFS NNP cord-005453-4057qib7 63 10 were be VBD cord-005453-4057qib7 63 11 higher high JJR cord-005453-4057qib7 63 12 with with IN cord-005453-4057qib7 63 13 prior prior JJ cord-005453-4057qib7 63 14 autologous autologous JJ cord-005453-4057qib7 63 15 HCT hct NN cord-005453-4057qib7 63 16 , , , cord-005453-4057qib7 63 17 1.17 1.17 CD cord-005453-4057qib7 63 18 ( ( -LRB- cord-005453-4057qib7 63 19 1.01 1.01 CD cord-005453-4057qib7 63 20 - - SYM cord-005453-4057qib7 63 21 1.35 1.35 CD cord-005453-4057qib7 63 22 ) ) -RRB- cord-005453-4057qib7 63 23 , , , cord-005453-4057qib7 63 24 p=0.03 p=0.03 NNP cord-005453-4057qib7 63 25 and and CC cord-005453-4057qib7 63 26 1.18 1.18 CD cord-005453-4057qib7 63 27 ( ( -LRB- cord-005453-4057qib7 63 28 1.03 1.03 CD cord-005453-4057qib7 63 29 - - SYM cord-005453-4057qib7 63 30 1.35 1.35 CD cord-005453-4057qib7 63 31 ) ) -RRB- cord-005453-4057qib7 63 32 p= p= NN cord-005453-4057qib7 63 33 0.02 0.02 CD cord-005453-4057qib7 63 34 , , , cord-005453-4057qib7 63 35 respectively respectively RB cord-005453-4057qib7 63 36 , , , cord-005453-4057qib7 63 37 risk risk NN cord-005453-4057qib7 63 38 of of IN cord-005453-4057qib7 63 39 death death NN cord-005453-4057qib7 63 40 was be VBD cord-005453-4057qib7 63 41 also also RB cord-005453-4057qib7 63 42 higher high JJR cord-005453-4057qib7 63 43 1.13 1.13 CD cord-005453-4057qib7 64 1 ( ( -LRB- cord-005453-4057qib7 64 2 0.974 0.974 CD cord-005453-4057qib7 64 3 - - SYM cord-005453-4057qib7 64 4 1.32 1.32 CD cord-005453-4057qib7 64 5 ) ) -RRB- cord-005453-4057qib7 64 6 p=0.1 p=0.1 NNS cord-005453-4057qib7 65 1 but but CC cord-005453-4057qib7 65 2 this this DT cord-005453-4057qib7 65 3 was be VBD cord-005453-4057qib7 65 4 not not RB cord-005453-4057qib7 65 5 statistically statistically RB cord-005453-4057qib7 65 6 significant significant JJ cord-005453-4057qib7 65 7 . . . cord-005453-4057qib7 66 1 Conclusions conclusion NNS cord-005453-4057qib7 66 2 : : : cord-005453-4057qib7 67 1 We -PRON- PRP cord-005453-4057qib7 67 2 may may MD cord-005453-4057qib7 67 3 conclude conclude VB cord-005453-4057qib7 67 4 that that IN cord-005453-4057qib7 67 5 some some DT cord-005453-4057qib7 67 6 of of IN cord-005453-4057qib7 67 7 the the DT cord-005453-4057qib7 67 8 advantages advantage NNS cord-005453-4057qib7 67 9 of of IN cord-005453-4057qib7 67 10 potentially potentially RB cord-005453-4057qib7 67 11 higher high JJR cord-005453-4057qib7 67 12 anti anti JJ cord-005453-4057qib7 67 13 - - JJ cord-005453-4057qib7 67 14 leukemic leukemic JJ cord-005453-4057qib7 67 15 activity activity NN cord-005453-4057qib7 67 16 of of IN cord-005453-4057qib7 67 17 high high JJ cord-005453-4057qib7 67 18 dose dose NN cord-005453-4057qib7 67 19 chemotherapy chemotherapy NN cord-005453-4057qib7 67 20 and and CC cord-005453-4057qib7 67 21 autologous autologous JJ cord-005453-4057qib7 67 22 HCT hct NN cord-005453-4057qib7 67 23 when when WRB cord-005453-4057qib7 67 24 given give VBN cord-005453-4057qib7 67 25 to to IN cord-005453-4057qib7 67 26 patients patient NNS cord-005453-4057qib7 67 27 with with IN cord-005453-4057qib7 67 28 AML AML NNP cord-005453-4057qib7 67 29 in in IN cord-005453-4057qib7 67 30 CR1(as cr1(as NN cord-005453-4057qib7 67 31 was be VBD cord-005453-4057qib7 67 32 shown show VBN cord-005453-4057qib7 67 33 in in IN cord-005453-4057qib7 67 34 a a DT cord-005453-4057qib7 67 35 randomized randomized JJ cord-005453-4057qib7 67 36 trial trial NN cord-005453-4057qib7 67 37 by by IN cord-005453-4057qib7 67 38 Vellenga Vellenga NNP cord-005453-4057qib7 67 39 E E NNP cord-005453-4057qib7 67 40 et et FW cord-005453-4057qib7 67 41 al al NNP cord-005453-4057qib7 67 42 with with IN cord-005453-4057qib7 67 43 lower low JJR cord-005453-4057qib7 67 44 relapse relapse NN cord-005453-4057qib7 67 45 and and CC cord-005453-4057qib7 67 46 higher high JJR cord-005453-4057qib7 67 47 LFS lfs NN cord-005453-4057qib7 67 48 by by IN cord-005453-4057qib7 67 49 approximately approximately RB cord-005453-4057qib7 67 50 10 10 CD cord-005453-4057qib7 67 51 % % NN cord-005453-4057qib7 67 52 but but CC cord-005453-4057qib7 67 53 no no DT cord-005453-4057qib7 67 54 significant significant JJ cord-005453-4057qib7 67 55 differences difference NNS cord-005453-4057qib7 67 56 in in IN cord-005453-4057qib7 67 57 overall overall JJ cord-005453-4057qib7 67 58 survival survival NN cord-005453-4057qib7 67 59 ) ) -RRB- cord-005453-4057qib7 67 60 may may MD cord-005453-4057qib7 67 61 be be VB cord-005453-4057qib7 67 62 lost lose VBN cord-005453-4057qib7 67 63 by by IN cord-005453-4057qib7 67 64 higher high JJR cord-005453-4057qib7 67 65 toxicity toxicity NN cord-005453-4057qib7 67 66 of of IN cord-005453-4057qib7 67 67 allogeneic allogeneic NN cord-005453-4057qib7 67 68 HCT hct NN cord-005453-4057qib7 67 69 in in IN cord-005453-4057qib7 67 70 CR2 CR2 NNP cord-005453-4057qib7 67 71 in in IN cord-005453-4057qib7 67 72 case case NN cord-005453-4057qib7 67 73 of of IN cord-005453-4057qib7 67 74 subsequent subsequent JJ cord-005453-4057qib7 67 75 relapse relapse NN cord-005453-4057qib7 67 76 . . . cord-005453-4057qib7 68 1 Background background NN cord-005453-4057qib7 68 2 : : : cord-005453-4057qib7 69 1 Although although IN cord-005453-4057qib7 69 2 relapse relapse NN cord-005453-4057qib7 69 3 is be VBZ cord-005453-4057qib7 69 4 a a DT cord-005453-4057qib7 69 5 major major JJ cord-005453-4057qib7 69 6 cause cause NN cord-005453-4057qib7 69 7 of of IN cord-005453-4057qib7 69 8 mortality mortality NN cord-005453-4057qib7 69 9 in in IN cord-005453-4057qib7 69 10 patients patient NNS cord-005453-4057qib7 69 11 receiving receive VBG cord-005453-4057qib7 69 12 allogeneic allogeneic JJ cord-005453-4057qib7 69 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 69 14 cell cell NN cord-005453-4057qib7 69 15 transplantation transplantation NN cord-005453-4057qib7 69 16 ( ( -LRB- cord-005453-4057qib7 69 17 HCT HCT NNP cord-005453-4057qib7 69 18 ) ) -RRB- cord-005453-4057qib7 69 19 for for IN cord-005453-4057qib7 69 20 acute acute JJ cord-005453-4057qib7 69 21 leukemia leukemia NN cord-005453-4057qib7 69 22 , , , cord-005453-4057qib7 70 1 limited limited JJ cord-005453-4057qib7 70 2 and and CC cord-005453-4057qib7 70 3 conflicting conflicting JJ cord-005453-4057qib7 70 4 data datum NNS cord-005453-4057qib7 70 5 exist exist VBP cord-005453-4057qib7 70 6 on on IN cord-005453-4057qib7 70 7 extramedullary extramedullary JJ cord-005453-4057qib7 70 8 relapse relapse NN cord-005453-4057qib7 70 9 ( ( -LRB- cord-005453-4057qib7 70 10 EMR EMR NNP cord-005453-4057qib7 70 11 ) ) -RRB- cord-005453-4057qib7 70 12 . . . cord-005453-4057qib7 71 1 We -PRON- PRP cord-005453-4057qib7 71 2 aimed aim VBD cord-005453-4057qib7 71 3 to to TO cord-005453-4057qib7 71 4 describe describe VB cord-005453-4057qib7 71 5 the the DT cord-005453-4057qib7 71 6 incidence incidence NN cord-005453-4057qib7 71 7 , , , cord-005453-4057qib7 71 8 risk risk NN cord-005453-4057qib7 71 9 factors factor NNS cord-005453-4057qib7 71 10 , , , cord-005453-4057qib7 71 11 outcomes outcome NNS cord-005453-4057qib7 71 12 and and CC cord-005453-4057qib7 71 13 prognosis prognosis NN cord-005453-4057qib7 71 14 in in IN cord-005453-4057qib7 71 15 relapsed relapse VBN cord-005453-4057qib7 71 16 HCT HCT NNP cord-005453-4057qib7 71 17 recipients recipient NNS cord-005453-4057qib7 71 18 . . . cord-005453-4057qib7 72 1 Methods method NNS cord-005453-4057qib7 72 2 : : : cord-005453-4057qib7 72 3 We -PRON- PRP cord-005453-4057qib7 72 4 retrospectively retrospectively RB cord-005453-4057qib7 72 5 reviewed review VBD cord-005453-4057qib7 72 6 charts chart NNS cord-005453-4057qib7 72 7 of of IN cord-005453-4057qib7 72 8 consecutive consecutive JJ cord-005453-4057qib7 72 9 allogeneic allogeneic NN cord-005453-4057qib7 72 10 HCT hct NN cord-005453-4057qib7 72 11 recipients recipient NNS cord-005453-4057qib7 72 12 transplanted transplant VBN cord-005453-4057qib7 72 13 in in IN cord-005453-4057qib7 72 14 our -PRON- PRP$ cord-005453-4057qib7 72 15 center center NN cord-005453-4057qib7 72 16 with with IN cord-005453-4057qib7 72 17 the the DT cord-005453-4057qib7 72 18 indication indication NN cord-005453-4057qib7 72 19 of of IN cord-005453-4057qib7 72 20 acute acute JJ cord-005453-4057qib7 72 21 leukemia leukemia NN cord-005453-4057qib7 72 22 ( ( -LRB- cord-005453-4057qib7 72 23 7/1990 7/1990 CD cord-005453-4057qib7 72 24 - - HYPH cord-005453-4057qib7 72 25 7/ 7/ CD cord-005453-4057qib7 72 26 2018 2018 CD cord-005453-4057qib7 72 27 ) ) -RRB- cord-005453-4057qib7 72 28 . . . cord-005453-4057qib7 73 1 We -PRON- PRP cord-005453-4057qib7 73 2 recorded record VBD cord-005453-4057qib7 73 3 : : : cord-005453-4057qib7 73 4 age age NN cord-005453-4057qib7 73 5 , , , cord-005453-4057qib7 73 6 gender gender NN cord-005453-4057qib7 73 7 , , , cord-005453-4057qib7 73 8 disease disease NN cord-005453-4057qib7 73 9 , , , cord-005453-4057qib7 73 10 previous previous JJ cord-005453-4057qib7 73 11 extramedullary extramedullary JJ cord-005453-4057qib7 73 12 involvement involvement NN cord-005453-4057qib7 73 13 , , , cord-005453-4057qib7 73 14 phase phase NN cord-005453-4057qib7 73 15 at at IN cord-005453-4057qib7 73 16 transplant transplant NN cord-005453-4057qib7 73 17 , , , cord-005453-4057qib7 73 18 type type NN cord-005453-4057qib7 73 19 of of IN cord-005453-4057qib7 73 20 transplant transplant NN cord-005453-4057qib7 73 21 , , , cord-005453-4057qib7 73 22 donor donor NN cord-005453-4057qib7 73 23 , , , cord-005453-4057qib7 73 24 conditioning conditioning NN cord-005453-4057qib7 73 25 , , , cord-005453-4057qib7 73 26 graft graft NN cord-005453-4057qib7 73 27 - - HYPH cord-005453-4057qib7 73 28 versus versus IN cord-005453-4057qib7 73 29 - - HYPH cord-005453-4057qib7 73 30 host host NN cord-005453-4057qib7 73 31 - - HYPH cord-005453-4057qib7 73 32 disease disease NN cord-005453-4057qib7 73 33 ( ( -LRB- cord-005453-4057qib7 73 34 GVHD GVHD NNP cord-005453-4057qib7 73 35 ) ) -RRB- cord-005453-4057qib7 73 36 , , , cord-005453-4057qib7 73 37 infections infection NNS cord-005453-4057qib7 73 38 , , , cord-005453-4057qib7 73 39 treatment treatment NN cord-005453-4057qib7 73 40 - - HYPH cord-005453-4057qib7 73 41 related relate VBN cord-005453-4057qib7 73 42 mortality mortality NN cord-005453-4057qib7 73 43 and and CC cord-005453-4057qib7 73 44 relapse relapse NN cord-005453-4057qib7 73 45 mortality mortality NN cord-005453-4057qib7 73 46 . . . cord-005453-4057qib7 74 1 In in IN cord-005453-4057qib7 74 2 patients patient NNS cord-005453-4057qib7 74 3 with with IN cord-005453-4057qib7 74 4 extramedullary extramedullary JJ cord-005453-4057qib7 74 5 relapses relapse NNS cord-005453-4057qib7 74 6 , , , cord-005453-4057qib7 74 7 additional additional JJ cord-005453-4057qib7 74 8 data datum NNS cord-005453-4057qib7 74 9 on on IN cord-005453-4057qib7 74 10 clinical clinical JJ cord-005453-4057qib7 74 11 manifestations manifestation NNS cord-005453-4057qib7 74 12 , , , cord-005453-4057qib7 74 13 imaging imaging NN cord-005453-4057qib7 74 14 , , , cord-005453-4057qib7 74 15 cerebrospinal cerebrospinal JJ cord-005453-4057qib7 74 16 fluid fluid JJ cord-005453-4057qib7 74 17 testing testing NN cord-005453-4057qib7 74 18 , , , cord-005453-4057qib7 74 19 histopathology histopathology NN cord-005453-4057qib7 74 20 and and CC cord-005453-4057qib7 74 21 management management NN cord-005453-4057qib7 74 22 were be VBD cord-005453-4057qib7 74 23 additionally additionally RB cord-005453-4057qib7 74 24 documented document VBN cord-005453-4057qib7 74 25 . . . cord-005453-4057qib7 75 1 Incidence incidence NN cord-005453-4057qib7 75 2 of of IN cord-005453-4057qib7 75 3 isolated isolate VBN cord-005453-4057qib7 75 4 EMR EMR NNP cord-005453-4057qib7 75 5 ( ( -LRB- cord-005453-4057qib7 75 6 iEMR iemr NN cord-005453-4057qib7 75 7 ) ) -RRB- cord-005453-4057qib7 75 8 and and CC cord-005453-4057qib7 75 9 bone bone NN cord-005453-4057qib7 75 10 marrow marrow NN cord-005453-4057qib7 75 11 relapse relapse NN cord-005453-4057qib7 75 12 ( ( -LRB- cord-005453-4057qib7 75 13 BMR BMR NNP cord-005453-4057qib7 75 14 ) ) -RRB- cord-005453-4057qib7 75 15 was be VBD cord-005453-4057qib7 75 16 calculated calculate VBN cord-005453-4057qib7 75 17 using use VBG cord-005453-4057qib7 75 18 cumulative cumulative JJ cord-005453-4057qib7 75 19 incidence incidence NN cord-005453-4057qib7 75 20 ( ( -LRB- cord-005453-4057qib7 75 21 CI CI NNP cord-005453-4057qib7 75 22 ) ) -RRB- cord-005453-4057qib7 75 23 analysis analysis NN cord-005453-4057qib7 75 24 , , , cord-005453-4057qib7 75 25 with with IN cord-005453-4057qib7 75 26 each each DT cord-005453-4057qib7 75 27 and and CC cord-005453-4057qib7 75 28 treatment treatment NN cord-005453-4057qib7 75 29 - - HYPH cord-005453-4057qib7 75 30 related relate VBN cord-005453-4057qib7 75 31 mortality mortality NN cord-005453-4057qib7 75 32 considered consider VBD cord-005453-4057qib7 75 33 a a DT cord-005453-4057qib7 75 34 competing compete VBG cord-005453-4057qib7 75 35 risk risk NN cord-005453-4057qib7 75 36 . . . cord-005453-4057qib7 76 1 Results result NNS cord-005453-4057qib7 76 2 : : : cord-005453-4057qib7 77 1 Among among IN cord-005453-4057qib7 77 2 554 554 CD cord-005453-4057qib7 77 3 alloHCT allohct XX cord-005453-4057qib7 78 1 recipients recipient NNS cord-005453-4057qib7 78 2 followed follow VBD cord-005453-4057qib7 78 3 for for IN cord-005453-4057qib7 78 4 1.8 1.8 CD cord-005453-4057qib7 78 5 ( ( -LRB- cord-005453-4057qib7 78 6 0.04 0.04 CD cord-005453-4057qib7 78 7 - - SYM cord-005453-4057qib7 78 8 27.75 27.75 CD cord-005453-4057qib7 78 9 ) ) -RRB- cord-005453-4057qib7 78 10 years year NNS cord-005453-4057qib7 78 11 , , , cord-005453-4057qib7 78 12 61 61 CD cord-005453-4057qib7 78 13 ( ( -LRB- cord-005453-4057qib7 78 14 11 11 CD cord-005453-4057qib7 78 15 % % NN cord-005453-4057qib7 78 16 ) ) -RRB- cord-005453-4057qib7 78 17 patients patient NNS cord-005453-4057qib7 78 18 presented present VBN cord-005453-4057qib7 78 19 with with IN cord-005453-4057qib7 78 20 EMR EMR NNP cord-005453-4057qib7 78 21 . . . cord-005453-4057qib7 79 1 The the DT cord-005453-4057qib7 79 2 majority majority NN cord-005453-4057qib7 79 3 of of IN cord-005453-4057qib7 79 4 EMRs emr NNS cord-005453-4057qib7 79 5 involved involve VBD cord-005453-4057qib7 79 6 the the DT cord-005453-4057qib7 79 7 central central JJ cord-005453-4057qib7 79 8 nervous nervous JJ cord-005453-4057qib7 79 9 system system NN cord-005453-4057qib7 79 10 ( ( -LRB- cord-005453-4057qib7 79 11 CNS CNS NNP cord-005453-4057qib7 79 12 , , , cord-005453-4057qib7 79 13 56 56 CD cord-005453-4057qib7 79 14 % % NN cord-005453-4057qib7 79 15 ) ) -RRB- cord-005453-4057qib7 79 16 . . . cord-005453-4057qib7 80 1 Isolated isolated JJ cord-005453-4057qib7 80 2 EMR EMR NNP cord-005453-4057qib7 80 3 was be VBD cord-005453-4057qib7 80 4 observed observe VBN cord-005453-4057qib7 80 5 in in IN cord-005453-4057qib7 80 6 38 38 CD cord-005453-4057qib7 80 7 patients patient NNS cord-005453-4057qib7 80 8 at at IN cord-005453-4057qib7 80 9 9.5 9.5 CD cord-005453-4057qib7 80 10 ( ( -LRB- cord-005453-4057qib7 80 11 1.8 1.8 CD cord-005453-4057qib7 80 12 - - HYPH cord-005453-4057qib7 80 13 67.3 67.3 CD cord-005453-4057qib7 80 14 ) ) -RRB- cord-005453-4057qib7 80 15 months month NNS cord-005453-4057qib7 80 16 . . . cord-005453-4057qib7 81 1 10-year 10-year CD cord-005453-4057qib7 81 2 cumulative cumulative JJ cord-005453-4057qib7 81 3 incidence incidence NN cord-005453-4057qib7 81 4 ( ( -LRB- cord-005453-4057qib7 81 5 CI CI NNP cord-005453-4057qib7 81 6 ) ) -RRB- cord-005453-4057qib7 81 7 of of IN cord-005453-4057qib7 81 8 10.5 10.5 CD cord-005453-4057qib7 81 9 % % NN cord-005453-4057qib7 81 10 for for IN cord-005453-4057qib7 81 11 iEMR iemr NN cord-005453-4057qib7 81 12 was be VBD cord-005453-4057qib7 81 13 associated associate VBN cord-005453-4057qib7 81 14 only only RB cord-005453-4057qib7 81 15 with with IN cord-005453-4057qib7 81 16 pre pre JJ cord-005453-4057qib7 81 17 - - JJ cord-005453-4057qib7 81 18 transplant transplant JJ cord-005453-4057qib7 81 19 advanced advanced JJ cord-005453-4057qib7 81 20 disease disease NN cord-005453-4057qib7 81 21 phase phase NN cord-005453-4057qib7 81 22 ( ( -LRB- cord-005453-4057qib7 81 23 p p NN cord-005453-4057qib7 81 24 < < XX cord-005453-4057qib7 81 25 0.001 0.001 CD cord-005453-4057qib7 81 26 ) ) -RRB- cord-005453-4057qib7 81 27 . . . cord-005453-4057qib7 82 1 BMR BMR NNP cord-005453-4057qib7 82 2 was be VBD cord-005453-4057qib7 82 3 observed observe VBN cord-005453-4057qib7 82 4 in in IN cord-005453-4057qib7 82 5 149 149 CD cord-005453-4057qib7 82 6 patients patient NNS cord-005453-4057qib7 82 7 at at IN cord-005453-4057qib7 82 8 9 9 CD cord-005453-4057qib7 82 9 ( ( -LRB- cord-005453-4057qib7 82 10 0.3 0.3 CD cord-005453-4057qib7 82 11 - - SYM cord-005453-4057qib7 82 12 276 276 CD cord-005453-4057qib7 82 13 months month NNS cord-005453-4057qib7 82 14 ) ) -RRB- cord-005453-4057qib7 82 15 , , , cord-005453-4057qib7 82 16 with with IN cord-005453-4057qib7 82 17 a a DT cord-005453-4057qib7 82 18 10-year 10-year CD cord-005453-4057qib7 82 19 CI CI NNP cord-005453-4057qib7 82 20 of of IN cord-005453-4057qib7 82 21 34.8 34.8 CD cord-005453-4057qib7 82 22 % % NN cord-005453-4057qib7 82 23 . . . cord-005453-4057qib7 83 1 In in IN cord-005453-4057qib7 83 2 the the DT cord-005453-4057qib7 83 3 multivariate multivariate JJ cord-005453-4057qib7 83 4 analysis analysis NN cord-005453-4057qib7 83 5 , , , cord-005453-4057qib7 83 6 BMR BMR NNP cord-005453-4057qib7 83 7 CI CI NNP cord-005453-4057qib7 83 8 was be VBD cord-005453-4057qib7 83 9 independently independently RB cord-005453-4057qib7 83 10 associated associate VBN cord-005453-4057qib7 83 11 with with IN cord-005453-4057qib7 83 12 fungal fungal JJ cord-005453-4057qib7 83 13 infections infection NNS cord-005453-4057qib7 83 14 ( ( -LRB- cord-005453-4057qib7 83 15 p p NN cord-005453-4057qib7 83 16 < < XX cord-005453-4057qib7 83 17 0.001 0.001 CD cord-005453-4057qib7 83 18 ) ) -RRB- cord-005453-4057qib7 83 19 , , , cord-005453-4057qib7 83 20 pre pre JJ cord-005453-4057qib7 83 21 - - JJ cord-005453-4057qib7 83 22 transplant transplant JJ cord-005453-4057qib7 83 23 disease disease NN cord-005453-4057qib7 83 24 phase phase NN cord-005453-4057qib7 83 25 ( ( -LRB- cord-005453-4057qib7 83 26 p p NN cord-005453-4057qib7 83 27 < < XX cord-005453-4057qib7 83 28 0.001 0.001 CD cord-005453-4057qib7 83 29 ) ) -RRB- cord-005453-4057qib7 83 30 and and CC cord-005453-4057qib7 83 31 lines line NNS cord-005453-4057qib7 83 32 of of IN cord-005453-4057qib7 83 33 treatment treatment NN cord-005453-4057qib7 83 34 ( ( -LRB- cord-005453-4057qib7 83 35 p=0.042 p=0.042 NNP cord-005453-4057qib7 83 36 ) ) -RRB- cord-005453-4057qib7 83 37 . . . cord-005453-4057qib7 84 1 10-year 10-year CD cord-005453-4057qib7 84 2 TRM TRM NNP cord-005453-4057qib7 84 3 of of IN cord-005453-4057qib7 84 4 our -PRON- PRP$ cord-005453-4057qib7 84 5 whole whole JJ cord-005453-4057qib7 84 6 cohort cohort NN cord-005453-4057qib7 84 7 was be VBD cord-005453-4057qib7 84 8 33.2 33.2 CD cord-005453-4057qib7 84 9 % % NN cord-005453-4057qib7 84 10 . . . cord-005453-4057qib7 85 1 The the DT cord-005453-4057qib7 85 2 majority majority NN cord-005453-4057qib7 85 3 of of IN cord-005453-4057qib7 85 4 iEMR iemr NN cord-005453-4057qib7 85 5 and and CC cord-005453-4057qib7 85 6 BMR BMR NNP cord-005453-4057qib7 85 7 ( ( -LRB- cord-005453-4057qib7 85 8 75 75 CD cord-005453-4057qib7 85 9 % % NN cord-005453-4057qib7 85 10 and and CC cord-005453-4057qib7 85 11 81 81 CD cord-005453-4057qib7 85 12 % % NN cord-005453-4057qib7 85 13 , , , cord-005453-4057qib7 85 14 respectively respectively RB cord-005453-4057qib7 85 15 ) ) -RRB- cord-005453-4057qib7 85 16 patients patient NNS cord-005453-4057qib7 85 17 received receive VBD cord-005453-4057qib7 85 18 systemic systemic JJ cord-005453-4057qib7 85 19 treatment treatment NN cord-005453-4057qib7 85 20 combined combine VBN cord-005453-4057qib7 85 21 with with IN cord-005453-4057qib7 85 22 local local JJ cord-005453-4057qib7 85 23 radiation radiation NN cord-005453-4057qib7 85 24 for for IN cord-005453-4057qib7 85 25 iEMR iemr NN cord-005453-4057qib7 85 26 ( ( -LRB- cord-005453-4057qib7 85 27 26 26 CD cord-005453-4057qib7 85 28 % % NN cord-005453-4057qib7 85 29 ) ) -RRB- cord-005453-4057qib7 85 30 and and CC cord-005453-4057qib7 85 31 donor donor NN cord-005453-4057qib7 85 32 lymphocyte lymphocyte NN cord-005453-4057qib7 85 33 infusions infusion NNS cord-005453-4057qib7 85 34 ( ( -LRB- cord-005453-4057qib7 85 35 DLIs dli NNS cord-005453-4057qib7 85 36 , , , cord-005453-4057qib7 85 37 16 16 CD cord-005453-4057qib7 85 38 % % NN cord-005453-4057qib7 85 39 and and CC cord-005453-4057qib7 85 40 28 28 CD cord-005453-4057qib7 85 41 % % NN cord-005453-4057qib7 85 42 respectively respectively RB cord-005453-4057qib7 85 43 ) ) -RRB- cord-005453-4057qib7 85 44 when when WRB cord-005453-4057qib7 85 45 feasible feasible JJ cord-005453-4057qib7 85 46 . . . cord-005453-4057qib7 86 1 Extensive extensive JJ cord-005453-4057qib7 86 2 chronic chronic JJ cord-005453-4057qib7 86 3 GVHD GVHD NNP cord-005453-4057qib7 86 4 was be VBD cord-005453-4057qib7 86 5 recorded record VBN cord-005453-4057qib7 86 6 in in IN cord-005453-4057qib7 86 7 47 47 CD cord-005453-4057qib7 86 8 % % NN cord-005453-4057qib7 86 9 of of IN cord-005453-4057qib7 86 10 iEMR iemr NN cord-005453-4057qib7 86 11 and and CC cord-005453-4057qib7 86 12 48 48 CD cord-005453-4057qib7 86 13 % % NN cord-005453-4057qib7 86 14 of of IN cord-005453-4057qib7 86 15 BMR BMR NNP cord-005453-4057qib7 86 16 patients patient NNS cord-005453-4057qib7 86 17 . . . cord-005453-4057qib7 87 1 Outcomes outcome NNS cord-005453-4057qib7 87 2 were be VBD cord-005453-4057qib7 87 3 poor poor JJ cord-005453-4057qib7 87 4 in in IN cord-005453-4057qib7 87 5 iEMR iemr NN cord-005453-4057qib7 87 6 , , , cord-005453-4057qib7 87 7 with with IN cord-005453-4057qib7 87 8 10-year 10-year CD cord-005453-4057qib7 87 9 overall overall JJ cord-005453-4057qib7 87 10 survival survival NN cord-005453-4057qib7 87 11 ( ( -LRB- cord-005453-4057qib7 87 12 OS OS NNP cord-005453-4057qib7 87 13 ) ) -RRB- cord-005453-4057qib7 87 14 of of IN cord-005453-4057qib7 87 15 18.3 18.3 CD cord-005453-4057qib7 87 16 % % NN cord-005453-4057qib7 87 17 . . . cord-005453-4057qib7 88 1 Favorable favorable JJ cord-005453-4057qib7 88 2 OS os NN cord-005453-4057qib7 88 3 in in IN cord-005453-4057qib7 88 4 iEMR iemr NN cord-005453-4057qib7 88 5 was be VBD cord-005453-4057qib7 88 6 associated associate VBN cord-005453-4057qib7 88 7 only only RB cord-005453-4057qib7 88 8 with with IN cord-005453-4057qib7 88 9 sibling sibling NN cord-005453-4057qib7 88 10 donors donor NNS cord-005453-4057qib7 88 11 ( ( -LRB- cord-005453-4057qib7 88 12 p=0.049 p=0.049 NNP cord-005453-4057qib7 88 13 ) ) -RRB- cord-005453-4057qib7 88 14 and and CC cord-005453-4057qib7 88 15 not not RB cord-005453-4057qib7 88 16 with with IN cord-005453-4057qib7 88 17 other other JJ cord-005453-4057qib7 88 18 factors factor NNS cord-005453-4057qib7 88 19 , , , cord-005453-4057qib7 88 20 such such JJ cord-005453-4057qib7 88 21 as as IN cord-005453-4057qib7 88 22 treatment treatment NN cord-005453-4057qib7 88 23 with with IN cord-005453-4057qib7 88 24 DLIs dli NNS cord-005453-4057qib7 88 25 or or CC cord-005453-4057qib7 88 26 presence presence NN cord-005453-4057qib7 88 27 of of IN cord-005453-4057qib7 88 28 chronic chronic JJ cord-005453-4057qib7 88 29 GVHD GVHD NNP cord-005453-4057qib7 88 30 . . . cord-005453-4057qib7 89 1 Similarly similarly RB cord-005453-4057qib7 89 2 poor poor JJ cord-005453-4057qib7 89 3 outcomes outcome NNS cord-005453-4057qib7 89 4 ( ( -LRB- cord-005453-4057qib7 90 1 10year 10year JJ cord-005453-4057qib7 90 2 OS os NN cord-005453-4057qib7 90 3 of of IN cord-005453-4057qib7 90 4 19.1 19.1 CD cord-005453-4057qib7 90 5 % % NN cord-005453-4057qib7 90 6 ) ) -RRB- cord-005453-4057qib7 90 7 were be VBD cord-005453-4057qib7 90 8 observed observe VBN cord-005453-4057qib7 90 9 in in IN cord-005453-4057qib7 90 10 BMR BMR NNP cord-005453-4057qib7 90 11 . . . cord-005453-4057qib7 91 1 Favorable favorable JJ cord-005453-4057qib7 91 2 OS OS NNP cord-005453-4057qib7 91 3 was be VBD cord-005453-4057qib7 91 4 independently independently RB cord-005453-4057qib7 91 5 associated associate VBN cord-005453-4057qib7 91 6 only only RB cord-005453-4057qib7 91 7 with with IN cord-005453-4057qib7 91 8 the the DT cord-005453-4057qib7 91 9 diagnosis diagnosis NN cord-005453-4057qib7 91 10 of of IN cord-005453-4057qib7 91 11 AML AML NNP cord-005453-4057qib7 91 12 ( ( -LRB- cord-005453-4057qib7 91 13 p=0.050 p=0.050 NNP cord-005453-4057qib7 91 14 ) ) -RRB- cord-005453-4057qib7 92 1 and and CC cord-005453-4057qib7 92 2 absence absence NN cord-005453-4057qib7 92 3 of of IN cord-005453-4057qib7 92 4 bacterial bacterial JJ cord-005453-4057qib7 92 5 infections infection NNS cord-005453-4057qib7 92 6 ( ( -LRB- cord-005453-4057qib7 92 7 p=0.049 p=0.049 NNP cord-005453-4057qib7 92 8 ) ) -RRB- cord-005453-4057qib7 92 9 . . . cord-005453-4057qib7 93 1 In in IN cord-005453-4057qib7 93 2 the the DT cord-005453-4057qib7 93 3 whole whole JJ cord-005453-4057qib7 93 4 cohort cohort NN cord-005453-4057qib7 93 5 , , , cord-005453-4057qib7 93 6 both both DT cord-005453-4057qib7 93 7 iEMR iemr NN cord-005453-4057qib7 93 8 and and CC cord-005453-4057qib7 93 9 BMR BMR NNP cord-005453-4057qib7 93 10 were be VBD cord-005453-4057qib7 93 11 independent independent JJ cord-005453-4057qib7 93 12 unfavorable unfavorable JJ cord-005453-4057qib7 93 13 predictors predictor NNS cord-005453-4057qib7 93 14 of of IN cord-005453-4057qib7 93 15 OS OS NNP cord-005453-4057qib7 93 16 ( ( -LRB- cord-005453-4057qib7 93 17 p p NN cord-005453-4057qib7 93 18 < < XX cord-005453-4057qib7 93 19 0.001 0.001 CD cord-005453-4057qib7 93 20 ) ) -RRB- cord-005453-4057qib7 93 21 along along IN cord-005453-4057qib7 93 22 with with IN cord-005453-4057qib7 93 23 extensive extensive JJ cord-005453-4057qib7 93 24 chronic chronic JJ cord-005453-4057qib7 93 25 GVHD GVHD NNP cord-005453-4057qib7 93 26 ( ( -LRB- cord-005453-4057qib7 93 27 p=0.012 p=0.012 NNP cord-005453-4057qib7 93 28 ) ) -RRB- cord-005453-4057qib7 93 29 . . . cord-005453-4057qib7 94 1 Conclusions conclusion NNS cord-005453-4057qib7 94 2 : : : cord-005453-4057qib7 95 1 In in IN cord-005453-4057qib7 95 2 a a DT cord-005453-4057qib7 95 3 large large JJ cord-005453-4057qib7 95 4 population population NN cord-005453-4057qib7 95 5 with with IN cord-005453-4057qib7 95 6 long long JJ cord-005453-4057qib7 95 7 - - HYPH cord-005453-4057qib7 95 8 term term NN cord-005453-4057qib7 95 9 follow follow NN cord-005453-4057qib7 95 10 - - HYPH cord-005453-4057qib7 95 11 up up NN cord-005453-4057qib7 95 12 , , , cord-005453-4057qib7 95 13 incidence incidence NN cord-005453-4057qib7 95 14 of of IN cord-005453-4057qib7 95 15 iEMR iemr NN cord-005453-4057qib7 95 16 was be VBD cord-005453-4057qib7 95 17 relatively relatively RB cord-005453-4057qib7 95 18 high high JJ cord-005453-4057qib7 95 19 , , , cord-005453-4057qib7 95 20 developed develop VBN cord-005453-4057qib7 95 21 at at IN cord-005453-4057qib7 95 22 the the DT cord-005453-4057qib7 95 23 late late JJ cord-005453-4057qib7 95 24 post post JJ cord-005453-4057qib7 95 25 - - JJ cord-005453-4057qib7 95 26 transplant transplant JJ cord-005453-4057qib7 95 27 period period NN cord-005453-4057qib7 95 28 and and CC cord-005453-4057qib7 95 29 associated associate VBN cord-005453-4057qib7 95 30 only only RB cord-005453-4057qib7 95 31 with with IN cord-005453-4057qib7 95 32 disease disease NN cord-005453-4057qib7 95 33 phase phase NN cord-005453-4057qib7 95 34 at at IN cord-005453-4057qib7 95 35 transplant transplant NN cord-005453-4057qib7 95 36 . . . cord-005453-4057qib7 96 1 Furthermore furthermore RB cord-005453-4057qib7 96 2 , , , cord-005453-4057qib7 96 3 iEMR iemr NN cord-005453-4057qib7 96 4 and and CC cord-005453-4057qib7 96 5 BMR BMR NNP cord-005453-4057qib7 96 6 conferred confer VBD cord-005453-4057qib7 96 7 similarly similarly RB cord-005453-4057qib7 96 8 poor poor JJ cord-005453-4057qib7 96 9 outcomes outcome NNS cord-005453-4057qib7 96 10 despite despite IN cord-005453-4057qib7 96 11 systemic systemic JJ cord-005453-4057qib7 96 12 treatment treatment NN cord-005453-4057qib7 96 13 or or CC cord-005453-4057qib7 96 14 extensive extensive JJ cord-005453-4057qib7 96 15 chronic chronic JJ cord-005453-4057qib7 96 16 GVHD GVHD NNP cord-005453-4057qib7 96 17 . . . cord-005453-4057qib7 97 1 These these DT cord-005453-4057qib7 97 2 independent independent JJ cord-005453-4057qib7 97 3 predictors predictor NNS cord-005453-4057qib7 97 4 of of IN cord-005453-4057qib7 97 5 survival survival NN cord-005453-4057qib7 97 6 highlight highlight VBP cord-005453-4057qib7 97 7 the the DT cord-005453-4057qib7 97 8 unmet unmet JJ cord-005453-4057qib7 97 9 clinical clinical JJ cord-005453-4057qib7 97 10 need need NN cord-005453-4057qib7 97 11 of of IN cord-005453-4057qib7 97 12 novel novel JJ cord-005453-4057qib7 97 13 approaches approach NNS cord-005453-4057qib7 97 14 either either CC cord-005453-4057qib7 97 15 as as IN cord-005453-4057qib7 97 16 maintenance maintenance NN cord-005453-4057qib7 97 17 or or CC cord-005453-4057qib7 97 18 treatment treatment NN cord-005453-4057qib7 97 19 to to TO cord-005453-4057qib7 97 20 reduce reduce VB cord-005453-4057qib7 97 21 extramedullary extramedullary JJ cord-005453-4057qib7 97 22 or or CC cord-005453-4057qib7 97 23 systemic systemic JJ cord-005453-4057qib7 97 24 relapse relapse NN cord-005453-4057qib7 97 25 post post NN cord-005453-4057qib7 97 26 alloHCT allohct XX cord-005453-4057qib7 97 27 for for IN cord-005453-4057qib7 97 28 acute acute JJ cord-005453-4057qib7 97 29 leukemia leukemia NN cord-005453-4057qib7 97 30 . . . cord-005453-4057qib7 98 1 Disclosure disclosure NN cord-005453-4057qib7 98 2 : : : cord-005453-4057qib7 98 3 No no DT cord-005453-4057qib7 98 4 competing compete VBG cord-005453-4057qib7 98 5 financial financial JJ cord-005453-4057qib7 98 6 interest interest NN cord-005453-4057qib7 98 7 . . . cord-005453-4057qib7 99 1 Impact impact NN cord-005453-4057qib7 99 2 of of IN cord-005453-4057qib7 99 3 T t NN cord-005453-4057qib7 99 4 - - HYPH cord-005453-4057qib7 99 5 cell cell NN cord-005453-4057qib7 99 6 depletion depletion NN cord-005453-4057qib7 99 7 on on IN cord-005453-4057qib7 99 8 outcome outcome NN cord-005453-4057qib7 99 9 in in IN cord-005453-4057qib7 99 10 patients patient NNS cord-005453-4057qib7 99 11 undergoing undergo VBG cord-005453-4057qib7 99 12 allogeneic allogeneic IN cord-005453-4057qib7 99 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 99 14 stem stem NN cord-005453-4057qib7 99 15 cell cell NN cord-005453-4057qib7 99 16 transplantation transplantation NN cord-005453-4057qib7 99 17 for for IN cord-005453-4057qib7 99 18 acute acute JJ cord-005453-4057qib7 99 19 myeloid myeloid NN cord-005453-4057qib7 99 20 leukemia leukemia NN cord-005453-4057qib7 99 21 Background background NN cord-005453-4057qib7 99 22 : : : cord-005453-4057qib7 100 1 After after IN cord-005453-4057qib7 100 2 a a DT cord-005453-4057qib7 100 3 diagnosis diagnosis NN cord-005453-4057qib7 100 4 of of IN cord-005453-4057qib7 100 5 acute acute JJ cord-005453-4057qib7 100 6 myeloid myeloid NN cord-005453-4057qib7 100 7 leukemia leukemia NN cord-005453-4057qib7 100 8 ( ( -LRB- cord-005453-4057qib7 100 9 AML AML NNP cord-005453-4057qib7 100 10 ) ) -RRB- cord-005453-4057qib7 101 1 the the DT cord-005453-4057qib7 101 2 majority majority NN cord-005453-4057qib7 101 3 of of IN cord-005453-4057qib7 101 4 patients patient NNS cord-005453-4057qib7 101 5 ( ( -LRB- cord-005453-4057qib7 101 6 pts pts NNP cord-005453-4057qib7 101 7 ) ) -RRB- cord-005453-4057qib7 101 8 who who WP cord-005453-4057qib7 101 9 achieve achieve VBP cord-005453-4057qib7 101 10 complete complete JJ cord-005453-4057qib7 101 11 remission remission NN cord-005453-4057qib7 101 12 ( ( -LRB- cord-005453-4057qib7 101 13 CR cr NN cord-005453-4057qib7 101 14 ) ) -RRB- cord-005453-4057qib7 101 15 eventually eventually RB cord-005453-4057qib7 101 16 relapse relapse VB cord-005453-4057qib7 101 17 , , , cord-005453-4057qib7 101 18 with with IN cord-005453-4057qib7 101 19 only only RB cord-005453-4057qib7 101 20 approximately approximately RB cord-005453-4057qib7 101 21 30 30 CD cord-005453-4057qib7 101 22 % % NN cord-005453-4057qib7 101 23 of of IN cord-005453-4057qib7 101 24 pts pt NNS cord-005453-4057qib7 101 25 maintaining maintain VBG cord-005453-4057qib7 101 26 CR CR NNP cord-005453-4057qib7 101 27 for for IN cord-005453-4057qib7 101 28 3 3 CD cord-005453-4057qib7 101 29 years year NNS cord-005453-4057qib7 101 30 or or CC cord-005453-4057qib7 101 31 longer long JJR cord-005453-4057qib7 101 32 . . . cord-005453-4057qib7 102 1 Late late JJ cord-005453-4057qib7 102 2 relapses relapse NNS cord-005453-4057qib7 102 3 ( ( -LRB- cord-005453-4057qib7 102 4 after after IN cord-005453-4057qib7 102 5 3 3 CD cord-005453-4057qib7 102 6 years year NNS cord-005453-4057qib7 102 7 in in IN cord-005453-4057qib7 102 8 CR CR NNP cord-005453-4057qib7 102 9 ) ) -RRB- cord-005453-4057qib7 102 10 occur occur VBP cord-005453-4057qib7 102 11 rarely rarely RB cord-005453-4057qib7 102 12 ( ( -LRB- cord-005453-4057qib7 102 13 6 6 CD cord-005453-4057qib7 102 14 - - SYM cord-005453-4057qib7 102 15 10 10 CD cord-005453-4057qib7 102 16 % % NN cord-005453-4057qib7 102 17 ) ) -RRB- cord-005453-4057qib7 102 18 in in IN cord-005453-4057qib7 102 19 pts pt NNS cord-005453-4057qib7 102 20 receiving receive VBG cord-005453-4057qib7 102 21 HSCT HSCT NNP cord-005453-4057qib7 102 22 in in IN cord-005453-4057qib7 102 23 CR1 CR1 NNP cord-005453-4057qib7 102 24 and and CC cord-005453-4057qib7 102 25 late late JJ cord-005453-4057qib7 102 26 effects effect NNS cord-005453-4057qib7 102 27 are be VBP cord-005453-4057qib7 102 28 followed follow VBN cord-005453-4057qib7 102 29 up up RP cord-005453-4057qib7 102 30 by by IN cord-005453-4057qib7 102 31 routine routine JJ cord-005453-4057qib7 102 32 surveillance surveillance NN cord-005453-4057qib7 102 33 as as RB cord-005453-4057qib7 102 34 well well RB cord-005453-4057qib7 102 35 as as IN cord-005453-4057qib7 102 36 preventative preventative JJ cord-005453-4057qib7 102 37 measures measure NNS cord-005453-4057qib7 102 38 . . . cord-005453-4057qib7 103 1 The the DT cord-005453-4057qib7 103 2 purpose purpose NN cord-005453-4057qib7 103 3 of of IN cord-005453-4057qib7 103 4 this this DT cord-005453-4057qib7 103 5 study study NN cord-005453-4057qib7 103 6 was be VBD cord-005453-4057qib7 103 7 to to TO cord-005453-4057qib7 103 8 investigate investigate VB cord-005453-4057qib7 103 9 long long JJ cord-005453-4057qib7 103 10 - - HYPH cord-005453-4057qib7 103 11 term term NN cord-005453-4057qib7 103 12 outcomes outcome NNS cord-005453-4057qib7 103 13 in in IN cord-005453-4057qib7 103 14 pts pts NN cord-005453-4057qib7 103 15 with with IN cord-005453-4057qib7 103 16 diagnosis diagnosis NN cord-005453-4057qib7 103 17 of of IN cord-005453-4057qib7 103 18 AML AML NNP cord-005453-4057qib7 103 19 undergoing undergo VBG cord-005453-4057qib7 103 20 HSCT HSCT NNP cord-005453-4057qib7 103 21 at at IN cord-005453-4057qib7 103 22 our -PRON- PRP$ cord-005453-4057qib7 103 23 Institution Institution NNP cord-005453-4057qib7 103 24 in in IN cord-005453-4057qib7 103 25 CR1 CR1 NNP cord-005453-4057qib7 103 26 . . . cord-005453-4057qib7 104 1 Methods method NNS cord-005453-4057qib7 104 2 : : : cord-005453-4057qib7 105 1 A a DT cord-005453-4057qib7 105 2 standardized standardized JJ cord-005453-4057qib7 105 3 follow follow NN cord-005453-4057qib7 105 4 - - HYPH cord-005453-4057qib7 105 5 up up NN cord-005453-4057qib7 105 6 of of IN cord-005453-4057qib7 105 7 HSCT HSCT NNP cord-005453-4057qib7 105 8 - - HYPH cord-005453-4057qib7 105 9 survivors survivor NNS cord-005453-4057qib7 105 10 is be VBZ cord-005453-4057qib7 105 11 applied apply VBN cord-005453-4057qib7 105 12 at at IN cord-005453-4057qib7 105 13 our -PRON- PRP$ cord-005453-4057qib7 105 14 center center NN cord-005453-4057qib7 105 15 . . . cord-005453-4057qib7 106 1 We -PRON- PRP cord-005453-4057qib7 106 2 analyzed analyze VBD cord-005453-4057qib7 106 3 116 116 CD cord-005453-4057qib7 106 4 adult adult NN cord-005453-4057qib7 106 5 pts pt NNS cord-005453-4057qib7 106 6 with with IN cord-005453-4057qib7 106 7 AML AML NNP cord-005453-4057qib7 106 8 in in IN cord-005453-4057qib7 106 9 CR1 CR1 NNP cord-005453-4057qib7 106 10 consecutively consecutively RB cord-005453-4057qib7 106 11 transplanted transplant VBN cord-005453-4057qib7 106 12 between between IN cord-005453-4057qib7 106 13 January January NNP cord-005453-4057qib7 106 14 2004 2004 CD cord-005453-4057qib7 106 15 and and CC cord-005453-4057qib7 106 16 December December NNP cord-005453-4057qib7 106 17 2016 2016 CD cord-005453-4057qib7 106 18 at at IN cord-005453-4057qib7 106 19 our -PRON- PRP$ cord-005453-4057qib7 106 20 Institution Institution NNP cord-005453-4057qib7 106 21 . . . cord-005453-4057qib7 107 1 A a DT cord-005453-4057qib7 107 2 written write VBN cord-005453-4057qib7 107 3 consent consent NN cord-005453-4057qib7 107 4 was be VBD cord-005453-4057qib7 107 5 given give VBN cord-005453-4057qib7 107 6 for for IN cord-005453-4057qib7 107 7 the the DT cord-005453-4057qib7 107 8 use use NN cord-005453-4057qib7 107 9 of of IN cord-005453-4057qib7 107 10 medical medical JJ cord-005453-4057qib7 107 11 records record NNS cord-005453-4057qib7 107 12 for for IN cord-005453-4057qib7 107 13 research research NN cord-005453-4057qib7 107 14 . . . cord-005453-4057qib7 108 1 A a DT cord-005453-4057qib7 108 2 landmark landmark NN cord-005453-4057qib7 108 3 analysis analysis NN cord-005453-4057qib7 108 4 was be VBD cord-005453-4057qib7 108 5 adopted adopt VBN cord-005453-4057qib7 108 6 for for IN cord-005453-4057qib7 108 7 patients patient NNS cord-005453-4057qib7 108 8 in in IN cord-005453-4057qib7 108 9 CR CR NNP cord-005453-4057qib7 108 10 at at IN cord-005453-4057qib7 108 11 2-y 2-y CD cord-005453-4057qib7 108 12 after after IN cord-005453-4057qib7 108 13 HSCT HSCT NNP cord-005453-4057qib7 108 14 ( ( -LRB- cord-005453-4057qib7 108 15 LTCR LTCR NNP cord-005453-4057qib7 108 16 -long -long JJ cord-005453-4057qib7 108 17 - - HYPH cord-005453-4057qib7 108 18 term term NN cord-005453-4057qib7 108 19 CR cr NN cord-005453-4057qib7 108 20 ) ) -RRB- cord-005453-4057qib7 108 21 . . . cord-005453-4057qib7 109 1 Results result NNS cord-005453-4057qib7 109 2 : : : cord-005453-4057qib7 110 1 LTCR LTCR NNP cord-005453-4057qib7 110 2 was be VBD cord-005453-4057qib7 110 3 achieved achieve VBN cord-005453-4057qib7 110 4 after after IN cord-005453-4057qib7 110 5 HSCT HSCT NNP cord-005453-4057qib7 110 6 in in IN cord-005453-4057qib7 110 7 91/116 91/116 CD cord-005453-4057qib7 110 8 patients patient NNS cord-005453-4057qib7 110 9 ( ( -LRB- cord-005453-4057qib7 110 10 male male JJ cord-005453-4057qib7 110 11 55 55 CD cord-005453-4057qib7 110 12 , , , cord-005453-4057qib7 110 13 female female JJ cord-005453-4057qib7 110 14 36 36 CD cord-005453-4057qib7 110 15 ) ) -RRB- cord-005453-4057qib7 110 16 transplanted transplant VBN cord-005453-4057qib7 110 17 in in IN cord-005453-4057qib7 110 18 CR1 CR1 NNP cord-005453-4057qib7 110 19 . . . cord-005453-4057qib7 111 1 The the DT cord-005453-4057qib7 111 2 median median JJ cord-005453-4057qib7 111 3 follow follow NN cord-005453-4057qib7 111 4 - - HYPH cord-005453-4057qib7 111 5 up up NN cord-005453-4057qib7 111 6 was be VBD cord-005453-4057qib7 111 7 6 6 CD cord-005453-4057qib7 111 8 years year NNS cord-005453-4057qib7 111 9 and and CC cord-005453-4057qib7 111 10 the the DT cord-005453-4057qib7 111 11 median median JJ cord-005453-4057qib7 111 12 age age NN cord-005453-4057qib7 111 13 at at IN cord-005453-4057qib7 111 14 transplant transplant NN cord-005453-4057qib7 111 15 52 52 CD cord-005453-4057qib7 111 16 years year NNS cord-005453-4057qib7 112 1 ( ( -LRB- cord-005453-4057qib7 112 2 r r NN cord-005453-4057qib7 112 3 20 20 CD cord-005453-4057qib7 112 4 - - SYM cord-005453-4057qib7 112 5 72 72 CD cord-005453-4057qib7 112 6 ) ) -RRB- cord-005453-4057qib7 112 7 . . . cord-005453-4057qib7 113 1 The the DT cord-005453-4057qib7 113 2 selected select VBN cord-005453-4057qib7 113 3 donor donor NN cord-005453-4057qib7 113 4 was be VBD cord-005453-4057qib7 113 5 a a DT cord-005453-4057qib7 113 6 family family NN cord-005453-4057qib7 113 7 haploidentical haploidentical JJ cord-005453-4057qib7 113 8 relative relative NN cord-005453-4057qib7 113 9 in in IN cord-005453-4057qib7 113 10 29 29 CD cord-005453-4057qib7 113 11 cases case NNS cord-005453-4057qib7 113 12 , , , cord-005453-4057qib7 113 13 an an DT cord-005453-4057qib7 113 14 HLA HLA NNP cord-005453-4057qib7 113 15 identical identical JJ cord-005453-4057qib7 113 16 relative relative NN cord-005453-4057qib7 113 17 in in IN cord-005453-4057qib7 113 18 21 21 CD cord-005453-4057qib7 113 19 , , , cord-005453-4057qib7 113 20 a a DT cord-005453-4057qib7 113 21 match match NN cord-005453-4057qib7 113 22 unrelated unrelated JJ cord-005453-4057qib7 113 23 donor donor NN cord-005453-4057qib7 113 24 in in IN cord-005453-4057qib7 113 25 39 39 CD cord-005453-4057qib7 113 26 and and CC cord-005453-4057qib7 113 27 a a DT cord-005453-4057qib7 113 28 cordblood cordblood NN cord-005453-4057qib7 113 29 in in IN cord-005453-4057qib7 113 30 2 2 CD cord-005453-4057qib7 113 31 . . . cord-005453-4057qib7 114 1 In in IN cord-005453-4057qib7 114 2 this this DT cord-005453-4057qib7 114 3 cohort cohort NN cord-005453-4057qib7 114 4 of of IN cord-005453-4057qib7 114 5 LTCR LTCR NNP cord-005453-4057qib7 114 6 , , , cord-005453-4057qib7 114 7 the the DT cord-005453-4057qib7 114 8 5-year 5-year CD cord-005453-4057qib7 114 9 overall overall JJ cord-005453-4057qib7 114 10 survival survival NN cord-005453-4057qib7 114 11 was be VBD cord-005453-4057qib7 114 12 92 92 CD cord-005453-4057qib7 114 13 % % NN cord-005453-4057qib7 114 14 ( ( -LRB- cord-005453-4057qib7 114 15 95 95 CD cord-005453-4057qib7 114 16 % % NN cord-005453-4057qib7 114 17 CI CI NNP cord-005453-4057qib7 114 18 83 83 CD cord-005453-4057qib7 114 19 - - SYM cord-005453-4057qib7 114 20 96 96 CD cord-005453-4057qib7 114 21 ) ) -RRB- cord-005453-4057qib7 114 22 . . . cord-005453-4057qib7 115 1 Cumulative cumulative JJ cord-005453-4057qib7 115 2 incidence incidence NN cord-005453-4057qib7 115 3 of of IN cord-005453-4057qib7 115 4 relapseevaluated relapseevaluated JJ cord-005453-4057qib7 115 5 in in IN cord-005453-4057qib7 115 6 competing compete VBG cord-005453-4057qib7 115 7 risk risk NN cord-005453-4057qib7 115 8 with with IN cord-005453-4057qib7 115 9 transplant transplant NN cord-005453-4057qib7 115 10 related relate VBN cord-005453-4057qib7 115 11 mortality mortality NN cord-005453-4057qib7 115 12 ( ( -LRB- cord-005453-4057qib7 115 13 TRM TRM NNP cord-005453-4057qib7 115 14 ) ) -RRB- cord-005453-4057qib7 116 1 -and -and : cord-005453-4057qib7 117 1 TRM TRM NNP cord-005453-4057qib7 117 2 -evaluated -evaluate VBN cord-005453-4057qib7 117 3 in in IN cord-005453-4057qib7 117 4 competing compete VBG cord-005453-4057qib7 117 5 risk risk NN cord-005453-4057qib7 117 6 with with IN cord-005453-4057qib7 117 7 relapse relapse NN cord-005453-4057qib7 117 8 -were -were RBR cord-005453-4057qib7 117 9 respectively respectively RB cord-005453-4057qib7 117 10 7 7 CD cord-005453-4057qib7 117 11 % % NN cord-005453-4057qib7 117 12 ( ( -LRB- cord-005453-4057qib7 117 13 95 95 CD cord-005453-4057qib7 117 14 % % NN cord-005453-4057qib7 117 15 CI CI NNP cord-005453-4057qib7 117 16 1 1 CD cord-005453-4057qib7 117 17 - - SYM cord-005453-4057qib7 117 18 23 23 CD cord-005453-4057qib7 117 19 ) ) -RRB- cord-005453-4057qib7 117 20 and and CC cord-005453-4057qib7 117 21 2 2 CD cord-005453-4057qib7 117 22 % % NN cord-005453-4057qib7 117 23 for for IN cord-005453-4057qib7 117 24 the the DT cord-005453-4057qib7 117 25 CR1 CR1 NNP cord-005453-4057qib7 117 26 cohort cohort NN cord-005453-4057qib7 117 27 . . . cord-005453-4057qib7 118 1 The the DT cord-005453-4057qib7 118 2 event event NN cord-005453-4057qib7 118 3 - - HYPH cord-005453-4057qib7 118 4 free free JJ cord-005453-4057qib7 118 5 - - HYPH cord-005453-4057qib7 118 6 survival survival NN cord-005453-4057qib7 118 7 ( ( -LRB- cord-005453-4057qib7 118 8 EFS EFS NNP cord-005453-4057qib7 118 9 ) ) -RRB- cord-005453-4057qib7 118 10 was be VBD cord-005453-4057qib7 118 11 91 91 CD cord-005453-4057qib7 118 12 % % NN cord-005453-4057qib7 118 13 ( ( -LRB- cord-005453-4057qib7 118 14 95 95 CD cord-005453-4057qib7 118 15 % % NN cord-005453-4057qib7 118 16 CI CI NNP cord-005453-4057qib7 118 17 83 83 CD cord-005453-4057qib7 118 18 - - SYM cord-005453-4057qib7 118 19 95 95 CD cord-005453-4057qib7 118 20 ) ) -RRB- cord-005453-4057qib7 118 21 . . . cord-005453-4057qib7 119 1 The the DT cord-005453-4057qib7 119 2 causes cause NNS cord-005453-4057qib7 119 3 of of IN cord-005453-4057qib7 119 4 death death NN cord-005453-4057qib7 119 5 were be VBD cord-005453-4057qib7 119 6 relapse relapse NN cord-005453-4057qib7 119 7 ( ( -LRB- cord-005453-4057qib7 119 8 6/10 6/10 CD cord-005453-4057qib7 119 9 pts pt NNS cord-005453-4057qib7 119 10 ) ) -RRB- cord-005453-4057qib7 119 11 , , , cord-005453-4057qib7 119 12 second second JJ cord-005453-4057qib7 119 13 cancer cancer NN cord-005453-4057qib7 119 14 ( ( -LRB- cord-005453-4057qib7 119 15 3/10 3/10 CD cord-005453-4057qib7 119 16 pts pt NNS cord-005453-4057qib7 119 17 ) ) -RRB- cord-005453-4057qib7 119 18 and and CC cord-005453-4057qib7 119 19 sepsis sepsis NN cord-005453-4057qib7 119 20 ( ( -LRB- cord-005453-4057qib7 119 21 1/10 1/10 CD cord-005453-4057qib7 119 22 pts pts NN cord-005453-4057qib7 119 23 ) ) -RRB- cord-005453-4057qib7 119 24 . . . cord-005453-4057qib7 120 1 The the DT cord-005453-4057qib7 120 2 5-year 5-year CD cord-005453-4057qib7 120 3 incidence incidence NN cord-005453-4057qib7 120 4 of of IN cord-005453-4057qib7 120 5 dyslipidemia dyslipidemia NN cord-005453-4057qib7 120 6 -defined -define VBN cord-005453-4057qib7 120 7 as as IN cord-005453-4057qib7 120 8 cholesterol cholesterol NN cord-005453-4057qib7 120 9 > > XX cord-005453-4057qib7 120 10 /= /= . cord-005453-4057qib7 121 1 200 200 CD cord-005453-4057qib7 121 2 mg mg NNP cord-005453-4057qib7 121 3 / / SYM cord-005453-4057qib7 121 4 dl dl NNP cord-005453-4057qib7 121 5 , , , cord-005453-4057qib7 121 6 and/or and/or CC cord-005453-4057qib7 122 1 LDL ldl NN cord-005453-4057qib7 123 1 > > XX cord-005453-4057qib7 123 2 /= /= CD cord-005453-4057qib7 123 3 115 115 CD cord-005453-4057qib7 123 4 mg mg NNP cord-005453-4057qib7 123 5 / / SYM cord-005453-4057qib7 123 6 dl dl NNP cord-005453-4057qib7 123 7 , , , cord-005453-4057qib7 123 8 and/or and/or CC cord-005453-4057qib7 123 9 triglycerides triglyceride NNS cord-005453-4057qib7 124 1 > > XX cord-005453-4057qib7 125 1 /= /= CD cord-005453-4057qib7 125 2 150 150 CD cord-005453-4057qib7 125 3 mg mg NNP cord-005453-4057qib7 125 4 / / SYM cord-005453-4057qib7 125 5 dl dl NNP cord-005453-4057qib7 125 6 or or CC cord-005453-4057qib7 125 7 need need VB cord-005453-4057qib7 125 8 for for IN cord-005453-4057qib7 125 9 specific specific JJ cord-005453-4057qib7 125 10 treatment treatment NN cord-005453-4057qib7 125 11 -was -was : cord-005453-4057qib7 125 12 24 24 CD cord-005453-4057qib7 125 13 % % NN cord-005453-4057qib7 125 14 . . . cord-005453-4057qib7 126 1 The the DT cord-005453-4057qib7 126 2 5-year 5-year CD cord-005453-4057qib7 126 3 incidence incidence NN cord-005453-4057qib7 126 4 of of IN cord-005453-4057qib7 126 5 osteopenia osteopenia NN cord-005453-4057qib7 126 6 / / SYM cord-005453-4057qib7 126 7 osteoporosisdefined osteoporosisdefine VBN cord-005453-4057qib7 126 8 as as IN cord-005453-4057qib7 126 9 T t NN cord-005453-4057qib7 126 10 - - HYPH cord-005453-4057qib7 126 11 score score NN cord-005453-4057qib7 126 12 lower low JJR cord-005453-4057qib7 126 13 than than IN cord-005453-4057qib7 126 14 -1 -1 NN cord-005453-4057qib7 126 15 and and CC cord-005453-4057qib7 126 16 greater great JJR cord-005453-4057qib7 126 17 than than IN cord-005453-4057qib7 126 18 -2.5 -2.5 NNP cord-005453-4057qib7 126 19 and and CC cord-005453-4057qib7 126 20 T t NN cord-005453-4057qib7 126 21 - - HYPH cord-005453-4057qib7 126 22 score score NN cord-005453-4057qib7 126 23 lower low JJR cord-005453-4057qib7 126 24 than than IN cord-005453-4057qib7 126 25 2.5 2.5 CD cord-005453-4057qib7 126 26 respectively respectively RB cord-005453-4057qib7 126 27 -was -was : cord-005453-4057qib7 126 28 38 38 CD cord-005453-4057qib7 126 29 % % NN cord-005453-4057qib7 126 30 . . . cord-005453-4057qib7 127 1 The the DT cord-005453-4057qib7 127 2 5-year 5-year CD cord-005453-4057qib7 127 3 incidence incidence NN cord-005453-4057qib7 127 4 of of IN cord-005453-4057qib7 127 5 second second JJ cord-005453-4057qib7 127 6 cancer cancer NN cord-005453-4057qib7 127 7 was be VBD cord-005453-4057qib7 127 8 11 11 CD cord-005453-4057qib7 127 9 % % NN cord-005453-4057qib7 127 10 : : : cord-005453-4057qib7 127 11 10 10 CD cord-005453-4057qib7 127 12 nonmelanoma nonmelanoma NN cord-005453-4057qib7 127 13 skin skin NN cord-005453-4057qib7 127 14 cancer cancer NN cord-005453-4057qib7 127 15 , , , cord-005453-4057qib7 127 16 2 2 CD cord-005453-4057qib7 127 17 lung lung NN cord-005453-4057qib7 127 18 carcinoma carcinoma NN cord-005453-4057qib7 127 19 , , , cord-005453-4057qib7 127 20 3 3 CD cord-005453-4057qib7 127 21 cervical cervical JJ cord-005453-4057qib7 127 22 intraepithelial intraepithelial JJ cord-005453-4057qib7 127 23 neoplasm neoplasm NN cord-005453-4057qib7 127 24 , , , cord-005453-4057qib7 127 25 1 1 CD cord-005453-4057qib7 127 26 thyroid thyroid NN cord-005453-4057qib7 127 27 cancer cancer NN cord-005453-4057qib7 127 28 , , , cord-005453-4057qib7 127 29 1 1 CD cord-005453-4057qib7 127 30 gastric gastric JJ cord-005453-4057qib7 127 31 cancer cancer NN cord-005453-4057qib7 127 32 and and CC cord-005453-4057qib7 127 33 1 1 CD cord-005453-4057qib7 127 34 colon colon NN cord-005453-4057qib7 127 35 cancer cancer NN cord-005453-4057qib7 127 36 . . . cord-005453-4057qib7 128 1 The the DT cord-005453-4057qib7 128 2 2-year 2-year CD cord-005453-4057qib7 128 3 incidence incidence NN cord-005453-4057qib7 128 4 of of IN cord-005453-4057qib7 128 5 chronic chronic JJ cord-005453-4057qib7 128 6 moderate moderate JJ cord-005453-4057qib7 128 7 - - HYPH cord-005453-4057qib7 128 8 severe severe JJ cord-005453-4057qib7 128 9 GvHD gvhd NN cord-005453-4057qib7 128 10 was be VBD cord-005453-4057qib7 128 11 27 27 CD cord-005453-4057qib7 128 12 % % NN cord-005453-4057qib7 128 13 ( ( -LRB- cord-005453-4057qib7 128 14 95 95 CD cord-005453-4057qib7 128 15 % % NN cord-005453-4057qib7 128 16 CI CI NNP cord-005453-4057qib7 128 17 13 13 CD cord-005453-4057qib7 128 18 - - SYM cord-005453-4057qib7 128 19 38 38 CD cord-005453-4057qib7 128 20 ) ) -RRB- cord-005453-4057qib7 128 21 , , , cord-005453-4057qib7 128 22 with with IN cord-005453-4057qib7 128 23 the the DT cord-005453-4057qib7 128 24 latest late JJS cord-005453-4057qib7 128 25 diagnosis diagnosis NN cord-005453-4057qib7 128 26 performed perform VBN cord-005453-4057qib7 128 27 on on IN cord-005453-4057qib7 128 28 day day NN cord-005453-4057qib7 128 29 570 570 CD cord-005453-4057qib7 128 30 . . . cord-005453-4057qib7 129 1 Of of IN cord-005453-4057qib7 129 2 note note NN cord-005453-4057qib7 129 3 , , , cord-005453-4057qib7 129 4 4/24 4/24 CD cord-005453-4057qib7 129 5 pts pt NNS cord-005453-4057qib7 129 6 are be VBP cord-005453-4057qib7 129 7 still still RB cord-005453-4057qib7 129 8 on on IN cord-005453-4057qib7 129 9 active active JJ cord-005453-4057qib7 129 10 treatment treatment NN cord-005453-4057qib7 129 11 at at IN cord-005453-4057qib7 129 12 last last JJ cord-005453-4057qib7 129 13 follow follow NN cord-005453-4057qib7 129 14 - - HYPH cord-005453-4057qib7 129 15 up up NN cord-005453-4057qib7 129 16 . . . cord-005453-4057qib7 130 1 Conclusions conclusion NNS cord-005453-4057qib7 130 2 : : : cord-005453-4057qib7 131 1 Relapse relapse NN cord-005453-4057qib7 131 2 incidence incidence NN cord-005453-4057qib7 131 3 is be VBZ cord-005453-4057qib7 131 4 low low JJ cord-005453-4057qib7 131 5 for for IN cord-005453-4057qib7 131 6 patient patient NN cord-005453-4057qib7 131 7 that that WDT cord-005453-4057qib7 131 8 reached reach VBD cord-005453-4057qib7 131 9 LTCR LTCR NNP cord-005453-4057qib7 131 10 : : : cord-005453-4057qib7 131 11 patients patient NNS cord-005453-4057qib7 131 12 in in IN cord-005453-4057qib7 131 13 CR1 CR1 NNP cord-005453-4057qib7 131 14 at at IN cord-005453-4057qib7 131 15 transplant transplant NN cord-005453-4057qib7 131 16 can can MD cord-005453-4057qib7 131 17 obtain obtain VB cord-005453-4057qib7 131 18 excellent excellent JJ cord-005453-4057qib7 131 19 OS os NN cord-005453-4057qib7 131 20 and and CC cord-005453-4057qib7 131 21 EFS efs NN cord-005453-4057qib7 131 22 once once RB cord-005453-4057qib7 131 23 reached reach VBD cord-005453-4057qib7 131 24 the the DT cord-005453-4057qib7 131 25 target target NN cord-005453-4057qib7 131 26 of of IN cord-005453-4057qib7 131 27 LTCR LTCR NNP cord-005453-4057qib7 131 28 . . . cord-005453-4057qib7 132 1 A a DT cord-005453-4057qib7 132 2 proactive proactive JJ cord-005453-4057qib7 132 3 long long JJ cord-005453-4057qib7 132 4 - - HYPH cord-005453-4057qib7 132 5 term term NN cord-005453-4057qib7 132 6 follow follow NN cord-005453-4057qib7 132 7 - - HYPH cord-005453-4057qib7 132 8 up up NN cord-005453-4057qib7 132 9 and and CC cord-005453-4057qib7 132 10 strategy strategy NN cord-005453-4057qib7 132 11 of of IN cord-005453-4057qib7 132 12 counseling counseling NN cord-005453-4057qib7 132 13 are be VBP cord-005453-4057qib7 132 14 essential essential JJ cord-005453-4057qib7 132 15 to to TO cord-005453-4057qib7 132 16 keep keep VB cord-005453-4057qib7 132 17 at at IN cord-005453-4057qib7 132 18 best good JJS cord-005453-4057qib7 132 19 quality quality NN cord-005453-4057qib7 132 20 the the DT cord-005453-4057qib7 132 21 survival survival NN cord-005453-4057qib7 132 22 advantage advantage NN cord-005453-4057qib7 132 23 offered offer VBN cord-005453-4057qib7 132 24 by by IN cord-005453-4057qib7 132 25 HSCT HSCT NNP cord-005453-4057qib7 132 26 in in IN cord-005453-4057qib7 132 27 patients patient NNS cord-005453-4057qib7 132 28 with with IN cord-005453-4057qib7 132 29 AML AML NNP cord-005453-4057qib7 132 30 in in IN cord-005453-4057qib7 132 31 CR1 CR1 NNP cord-005453-4057qib7 132 32 . . . cord-005453-4057qib7 133 1 Disclosure disclosure NN cord-005453-4057qib7 133 2 : : : cord-005453-4057qib7 134 1 Chiara Chiara NNP cord-005453-4057qib7 134 2 Bonini Bonini NNP cord-005453-4057qib7 134 3 has have VBZ cord-005453-4057qib7 134 4 research research NN cord-005453-4057qib7 134 5 contract contract NN cord-005453-4057qib7 134 6 with with IN cord-005453-4057qib7 134 7 Intellia Intellia NNP cord-005453-4057qib7 134 8 Therapeutics Therapeutics NNP cord-005453-4057qib7 134 9 . . . cord-005453-4057qib7 135 1 The the DT cord-005453-4057qib7 135 2 other other JJ cord-005453-4057qib7 135 3 authors author NNS cord-005453-4057qib7 135 4 declare declare VBP cord-005453-4057qib7 135 5 that that IN cord-005453-4057qib7 135 6 they -PRON- PRP cord-005453-4057qib7 135 7 have have VBP cord-005453-4057qib7 135 8 no no DT cord-005453-4057qib7 135 9 conflicts conflict NNS cord-005453-4057qib7 135 10 of of IN cord-005453-4057qib7 135 11 interest interest NN cord-005453-4057qib7 135 12 . . . cord-005453-4057qib7 136 1 Background background NN cord-005453-4057qib7 136 2 : : : cord-005453-4057qib7 137 1 Relapse relapse NN cord-005453-4057qib7 137 2 , , , cord-005453-4057qib7 137 3 graft graft NN cord-005453-4057qib7 137 4 - - HYPH cord-005453-4057qib7 137 5 versus versus IN cord-005453-4057qib7 137 6 - - HYPH cord-005453-4057qib7 137 7 host host NN cord-005453-4057qib7 137 8 disease disease NN cord-005453-4057qib7 137 9 ( ( -LRB- cord-005453-4057qib7 137 10 GvHD GvHD NNP cord-005453-4057qib7 137 11 ) ) -RRB- cord-005453-4057qib7 137 12 and and CC cord-005453-4057qib7 137 13 GvHD gvhd NN cord-005453-4057qib7 137 14 - - HYPH cord-005453-4057qib7 137 15 associated associate VBN cord-005453-4057qib7 137 16 mortality mortality NN cord-005453-4057qib7 137 17 are be VBP cord-005453-4057qib7 137 18 major major JJ cord-005453-4057qib7 137 19 obstacles obstacle NNS cord-005453-4057qib7 137 20 to to IN cord-005453-4057qib7 137 21 success success NN cord-005453-4057qib7 137 22 of of IN cord-005453-4057qib7 137 23 transplantation transplantation NN cord-005453-4057qib7 137 24 from from IN cord-005453-4057qib7 137 25 unrelated unrelated JJ cord-005453-4057qib7 137 26 ( ( -LRB- cord-005453-4057qib7 137 27 MUD mud NN cord-005453-4057qib7 137 28 ) ) -RRB- cord-005453-4057qib7 137 29 donors donor NNS cord-005453-4057qib7 137 30 in in IN cord-005453-4057qib7 137 31 children child NNS cord-005453-4057qib7 137 32 with with IN cord-005453-4057qib7 137 33 acute acute JJ cord-005453-4057qib7 137 34 leukemia leukemia NN cord-005453-4057qib7 137 35 ( ( -LRB- cord-005453-4057qib7 137 36 AL AL NNP cord-005453-4057qib7 137 37 ) ) -RRB- cord-005453-4057qib7 137 38 . . . cord-005453-4057qib7 138 1 Negative negative JJ cord-005453-4057qib7 138 2 depletion depletion NN cord-005453-4057qib7 138 3 of of IN cord-005453-4057qib7 138 4 αβ αβ FW cord-005453-4057qib7 138 5 T t NN cord-005453-4057qib7 138 6 cells cell NNS cord-005453-4057qib7 138 7 and and CC cord-005453-4057qib7 138 8 CD19 CD19 NNP cord-005453-4057qib7 138 9 + + CC cord-005453-4057qib7 138 10 B b NN cord-005453-4057qib7 138 11 lymphocytes lymphocyte NNS cord-005453-4057qib7 138 12 , , , cord-005453-4057qib7 138 13 conserves conserve VBZ cord-005453-4057qib7 138 14 the the DT cord-005453-4057qib7 138 15 mature mature JJ cord-005453-4057qib7 138 16 donor donor NN cord-005453-4057qib7 138 17 - - HYPH cord-005453-4057qib7 138 18 derived derive VBN cord-005453-4057qib7 138 19 natural natural JJ cord-005453-4057qib7 138 20 killer killer NN cord-005453-4057qib7 138 21 cells cell NNS cord-005453-4057qib7 138 22 and and CC cord-005453-4057qib7 138 23 γδ γδ NN cord-005453-4057qib7 138 24 T t NN cord-005453-4057qib7 138 25 cells cell NNS cord-005453-4057qib7 138 26 in in IN cord-005453-4057qib7 138 27 the the DT cord-005453-4057qib7 138 28 graft graft NN cord-005453-4057qib7 138 29 , , , cord-005453-4057qib7 138 30 may may MD cord-005453-4057qib7 138 31 improve improve VB cord-005453-4057qib7 138 32 GvHD GvHD NNP cord-005453-4057qib7 138 33 control control NN cord-005453-4057qib7 138 34 , , , cord-005453-4057qib7 138 35 immune immune JJ cord-005453-4057qib7 138 36 reconstitution reconstitution NN cord-005453-4057qib7 138 37 and and CC cord-005453-4057qib7 138 38 prevent prevent VB cord-005453-4057qib7 138 39 the the DT cord-005453-4057qib7 138 40 relapse relapse NN cord-005453-4057qib7 138 41 . . . cord-005453-4057qib7 139 1 We -PRON- PRP cord-005453-4057qib7 139 2 present present VBP cord-005453-4057qib7 139 3 a a DT cord-005453-4057qib7 139 4 retrospect retrospect JJ cord-005453-4057qib7 139 5 analyses analysis NNS cord-005453-4057qib7 139 6 of of IN cord-005453-4057qib7 139 7 a a DT cord-005453-4057qib7 139 8 cohort cohort NN cord-005453-4057qib7 139 9 of of IN cord-005453-4057qib7 139 10 pts pts NN cord-005453-4057qib7 139 11 with with IN cord-005453-4057qib7 139 12 AL AL NNP cord-005453-4057qib7 139 13 in in IN cord-005453-4057qib7 139 14 CR CR NNP cord-005453-4057qib7 139 15 transplanted transplant VBN cord-005453-4057qib7 139 16 from from IN cord-005453-4057qib7 139 17 MUD mud NN cord-005453-4057qib7 139 18 with with IN cord-005453-4057qib7 139 19 depletion depletion NN cord-005453-4057qib7 139 20 . . . cord-005453-4057qib7 140 1 Methods method NNS cord-005453-4057qib7 140 2 : : : cord-005453-4057qib7 141 1 A a DT cord-005453-4057qib7 141 2 total total NN cord-005453-4057qib7 141 3 of of IN cord-005453-4057qib7 141 4 59 59 CD cord-005453-4057qib7 141 5 children child NNS cord-005453-4057qib7 141 6 with with IN cord-005453-4057qib7 141 7 acute acute JJ cord-005453-4057qib7 141 8 leukemia leukemia NN cord-005453-4057qib7 141 9 ( ( -LRB- cord-005453-4057qib7 141 10 34 34 CD cord-005453-4057qib7 141 11 AML AML NNP cord-005453-4057qib7 141 12 , , , cord-005453-4057qib7 141 13 25 25 CD cord-005453-4057qib7 141 14 ALL all DT cord-005453-4057qib7 141 15 , , , cord-005453-4057qib7 141 16 21 21 CD cord-005453-4057qib7 141 17 female female NN cord-005453-4057qib7 141 18 , , , cord-005453-4057qib7 141 19 38 38 CD cord-005453-4057qib7 141 20 male male NN cord-005453-4057qib7 141 21 , , , cord-005453-4057qib7 141 22 median median JJ cord-005453-4057qib7 141 23 age age NN cord-005453-4057qib7 141 24 8,5y 8,5y CD cord-005453-4057qib7 141 25 ) ) -RRB- cord-005453-4057qib7 141 26 underwent undergo VBD cord-005453-4057qib7 141 27 allo allo NNP cord-005453-4057qib7 141 28 HSCT HSCT NNP cord-005453-4057qib7 141 29 from from IN cord-005453-4057qib7 141 30 matched match VBN cord-005453-4057qib7 141 31 unrelated unrelated JJ cord-005453-4057qib7 141 32 donor donor NN cord-005453-4057qib7 141 33 between between IN cord-005453-4057qib7 141 34 June June NNP cord-005453-4057qib7 141 35 2012 2012 CD cord-005453-4057qib7 141 36 and and CC cord-005453-4057qib7 141 37 July July NNP cord-005453-4057qib7 141 38 2017 2017 CD cord-005453-4057qib7 141 39 . . . cord-005453-4057qib7 142 1 All all DT cord-005453-4057qib7 142 2 pts pt NNS cord-005453-4057qib7 142 3 were be VBD cord-005453-4057qib7 142 4 in in IN cord-005453-4057qib7 142 5 complete complete JJ cord-005453-4057qib7 142 6 remission remission NN cord-005453-4057qib7 142 7 ( ( -LRB- cord-005453-4057qib7 142 8 CR1=34 cr1=34 NN cord-005453-4057qib7 142 9 , , , cord-005453-4057qib7 142 10 CR2=23 cr2=23 NN cord-005453-4057qib7 142 11 , , , cord-005453-4057qib7 142 12 CR>2=2 CR>2=2 NNP cord-005453-4057qib7 142 13 ) ) -RRB- cord-005453-4057qib7 142 14 . . . cord-005453-4057qib7 143 1 All all DT cord-005453-4057qib7 143 2 pts pt NNS cord-005453-4057qib7 143 3 , , , cord-005453-4057qib7 143 4 except except IN cord-005453-4057qib7 143 5 one one CD cord-005453-4057qib7 143 6 , , , cord-005453-4057qib7 143 7 received receive VBD cord-005453-4057qib7 143 8 treosulfan treosulfan NNP cord-005453-4057qib7 143 9 - - HYPH cord-005453-4057qib7 143 10 based base VBN cord-005453-4057qib7 143 11 conditioning conditioning NN cord-005453-4057qib7 143 12 . . . cord-005453-4057qib7 144 1 Either either CC cord-005453-4057qib7 144 2 melphalan melphalan NNP cord-005453-4057qib7 144 3 ( ( -LRB- cord-005453-4057qib7 144 4 n=56 n=56 NNP cord-005453-4057qib7 144 5 ) ) -RRB- cord-005453-4057qib7 144 6 or or CC cord-005453-4057qib7 144 7 thiophosphamide thiophosphamide NNP cord-005453-4057qib7 144 8 ( ( -LRB- cord-005453-4057qib7 144 9 n=2 n=2 NNS cord-005453-4057qib7 144 10 ) ) -RRB- cord-005453-4057qib7 144 11 or or CC cord-005453-4057qib7 144 12 etoposide etoposide JJ cord-005453-4057qib7 144 13 ( ( -LRB- cord-005453-4057qib7 144 14 n=1 n=1 NN cord-005453-4057qib7 144 15 ) ) -RRB- cord-005453-4057qib7 144 16 were be VBD cord-005453-4057qib7 144 17 added add VBN cord-005453-4057qib7 144 18 as as IN cord-005453-4057qib7 144 19 a a DT cord-005453-4057qib7 144 20 second second JJ cord-005453-4057qib7 144 21 agent agent NN cord-005453-4057qib7 144 22 . . . cord-005453-4057qib7 145 1 Fludarabine Fludarabine NNP cord-005453-4057qib7 145 2 was be VBD cord-005453-4057qib7 145 3 used use VBN cord-005453-4057qib7 145 4 in in IN cord-005453-4057qib7 145 5 all all DT cord-005453-4057qib7 145 6 pts pt NNS cord-005453-4057qib7 145 7 . . . cord-005453-4057qib7 146 1 Two two CD cord-005453-4057qib7 146 2 types type NNS cord-005453-4057qib7 146 3 of of IN cord-005453-4057qib7 146 4 GVHD GVHD NNP cord-005453-4057qib7 146 5 prophylaxis prophylaxis NN cord-005453-4057qib7 146 6 were be VBD cord-005453-4057qib7 146 7 used use VBN cord-005453-4057qib7 146 8 : : : cord-005453-4057qib7 146 9 Type type NN cord-005453-4057qib7 146 10 1 1 CD cord-005453-4057qib7 146 11 ( ( -LRB- cord-005453-4057qib7 146 12 n=35 n=35 NNP cord-005453-4057qib7 146 13 ) ) -RRB- cord-005453-4057qib7 146 14 : : : cord-005453-4057qib7 146 15 hATG hatg ADD cord-005453-4057qib7 147 1 50 50 CD cord-005453-4057qib7 148 1 mg mg NNP cord-005453-4057qib7 148 2 / / SYM cord-005453-4057qib7 148 3 kg kg NNP cord-005453-4057qib7 148 4 and and CC cord-005453-4057qib7 148 5 post post JJ cord-005453-4057qib7 148 6 - - JJ cord-005453-4057qib7 148 7 HSCT HSCT NNP cord-005453-4057qib7 148 8 tacro tacro NNP cord-005453-4057qib7 148 9 / / SYM cord-005453-4057qib7 148 10 mtx mtx NNP cord-005453-4057qib7 148 11 ( ( -LRB- cord-005453-4057qib7 148 12 n=30 n=30 NNP cord-005453-4057qib7 148 13 ) ) -RRB- cord-005453-4057qib7 148 14 or or CC cord-005453-4057qib7 148 15 without without IN cord-005453-4057qib7 148 16 prophylaxis prophylaxis NN cord-005453-4057qib7 148 17 ( ( -LRB- cord-005453-4057qib7 148 18 n=5 n=5 NNP cord-005453-4057qib7 148 19 ) ) -RRB- cord-005453-4057qib7 148 20 ; ; . cord-005453-4057qib7 149 1 type type NN cord-005453-4057qib7 149 2 2 2 CD cord-005453-4057qib7 150 1 ( ( -LRB- cord-005453-4057qib7 150 2 n=24 n=24 NNP cord-005453-4057qib7 150 3 ) ) -RRB- cord-005453-4057qib7 151 1 : : : cord-005453-4057qib7 151 2 thymoglobulin(rATG thymoglobulin(rATG NNP cord-005453-4057qib7 151 3 ) ) -RRB- cord-005453-4057qib7 151 4 5 5 CD cord-005453-4057qib7 151 5 mg mg NN cord-005453-4057qib7 152 1 /kg /kg NFP cord-005453-4057qib7 152 2 , , , cord-005453-4057qib7 152 3 rituximab rituximab VBG cord-005453-4057qib7 152 4 200mg/ 200mg/ CD cord-005453-4057qib7 152 5 m m CD cord-005453-4057qib7 152 6 2 2 CD cord-005453-4057qib7 152 7 with with IN cord-005453-4057qib7 152 8 either either DT cord-005453-4057qib7 152 9 bortezomib bortezomib NNP cord-005453-4057qib7 152 10 on on IN cord-005453-4057qib7 152 11 days day NNS cord-005453-4057qib7 152 12 +2 +2 NN cord-005453-4057qib7 152 13 , , , cord-005453-4057qib7 152 14 +5 +5 FW cord-005453-4057qib7 152 15 ( ( -LRB- cord-005453-4057qib7 152 16 n=21 n=21 NNP cord-005453-4057qib7 152 17 ) ) -RRB- cord-005453-4057qib7 152 18 or or CC cord-005453-4057qib7 152 19 tacro/ tacro/ NN cord-005453-4057qib7 152 20 mtx mtx NN cord-005453-4057qib7 152 21 ( ( -LRB- cord-005453-4057qib7 152 22 n=3 n=3 NN cord-005453-4057qib7 152 23 ) ) -RRB- cord-005453-4057qib7 152 24 . . . cord-005453-4057qib7 153 1 aβ aβ NNP cord-005453-4057qib7 153 2 T t NN cord-005453-4057qib7 153 3 cell cell NN cord-005453-4057qib7 153 4 depletion depletion NN cord-005453-4057qib7 153 5 with with IN cord-005453-4057qib7 153 6 CliniMACS CliniMACS NNP cord-005453-4057qib7 153 7 was be VBD cord-005453-4057qib7 153 8 used use VBN cord-005453-4057qib7 153 9 in in IN cord-005453-4057qib7 153 10 all all DT cord-005453-4057qib7 153 11 cases case NNS cord-005453-4057qib7 153 12 . . . cord-005453-4057qib7 154 1 The the DT cord-005453-4057qib7 154 2 median median JJ cord-005453-4057qib7 154 3 dose dose NN cord-005453-4057qib7 154 4 of of IN cord-005453-4057qib7 154 5 CD34 CD34 NNP cord-005453-4057qib7 154 6 + + CC cord-005453-4057qib7 154 7 cells cell NNS cord-005453-4057qib7 154 8 was be VBD cord-005453-4057qib7 154 9 9 9 CD cord-005453-4057qib7 154 10 x10 x10 CD cord-005453-4057qib7 154 11 6 6 CD cord-005453-4057qib7 154 12 / / SYM cord-005453-4057qib7 154 13 kg kg NNS cord-005453-4057qib7 154 14 , , , cord-005453-4057qib7 154 15 aβ aβ NNP cord-005453-4057qib7 154 16 T t NN cord-005453-4057qib7 154 17 cells cell NNS cord-005453-4057qib7 155 1 -15 -15 CD cord-005453-4057qib7 156 1 x10 x10 NN cord-005453-4057qib7 156 2 3 3 CD cord-005453-4057qib7 157 1 /kg /kg NFP cord-005453-4057qib7 157 2 . . . cord-005453-4057qib7 158 1 Median median JJ cord-005453-4057qib7 158 2 time time NN cord-005453-4057qib7 158 3 of of IN cord-005453-4057qib7 158 4 follow follow NN cord-005453-4057qib7 158 5 - - HYPH cord-005453-4057qib7 158 6 up up NN cord-005453-4057qib7 158 7 for for IN cord-005453-4057qib7 158 8 survivors survivor NNS cord-005453-4057qib7 158 9 was be VBD cord-005453-4057qib7 158 10 5,3 5,3 CD cord-005453-4057qib7 158 11 years year NNS cord-005453-4057qib7 158 12 ( ( -LRB- cord-005453-4057qib7 158 13 range range NN cord-005453-4057qib7 158 14 , , , cord-005453-4057qib7 158 15 2 2 CD cord-005453-4057qib7 158 16 , , , cord-005453-4057qib7 158 17 3 3 CD cord-005453-4057qib7 158 18 -6,5 -6,5 NN cord-005453-4057qib7 158 19 ) ) -RRB- cord-005453-4057qib7 158 20 . . . cord-005453-4057qib7 159 1 Results result NNS cord-005453-4057qib7 159 2 : : : cord-005453-4057qib7 160 1 Primary primary JJ cord-005453-4057qib7 160 2 engraftment engraftment NN cord-005453-4057qib7 160 3 was be VBD cord-005453-4057qib7 160 4 achieved achieve VBN cord-005453-4057qib7 160 5 in in IN cord-005453-4057qib7 160 6 100 100 CD cord-005453-4057qib7 160 7 % % NN cord-005453-4057qib7 160 8 pts pt NNS cord-005453-4057qib7 160 9 . . . cord-005453-4057qib7 161 1 , , , cord-005453-4057qib7 161 2 the the DT cord-005453-4057qib7 161 3 median median JJ cord-005453-4057qib7 161 4 time time NN cord-005453-4057qib7 161 5 to to IN cord-005453-4057qib7 161 6 neutrophil neutrophil NN cord-005453-4057qib7 161 7 and and CC cord-005453-4057qib7 161 8 platelet platelet NN cord-005453-4057qib7 161 9 recovery recovery NN cord-005453-4057qib7 161 10 was be VBD cord-005453-4057qib7 161 11 15 15 CD cord-005453-4057qib7 161 12 and and CC cord-005453-4057qib7 161 13 14 14 CD cord-005453-4057qib7 161 14 days day NNS cord-005453-4057qib7 161 15 , , , cord-005453-4057qib7 161 16 respectively respectively RB cord-005453-4057qib7 161 17 . . . cord-005453-4057qib7 162 1 All all DT cord-005453-4057qib7 162 2 evaluable evaluable JJ cord-005453-4057qib7 162 3 pts pts NN cord-005453-4057qib7 162 4 achieved achieve VBN cord-005453-4057qib7 162 5 sustained sustain VBN cord-005453-4057qib7 162 6 complete complete JJ cord-005453-4057qib7 162 7 donor donor NN cord-005453-4057qib7 162 8 chimerism chimerism NN cord-005453-4057qib7 162 9 by by IN cord-005453-4057qib7 162 10 day day NN cord-005453-4057qib7 162 11 +30 +30 CD cord-005453-4057qib7 162 12 . . . cord-005453-4057qib7 163 1 Early early RB cord-005453-4057qib7 163 2 ( ( -LRB- cord-005453-4057qib7 163 3 100 100 CD cord-005453-4057qib7 163 4 day day NN cord-005453-4057qib7 163 5 ) ) -RRB- cord-005453-4057qib7 163 6 mortality mortality NN cord-005453-4057qib7 163 7 was be VBD cord-005453-4057qib7 163 8 3,4 3,4 CD cord-005453-4057qib7 163 9 % % NN cord-005453-4057qib7 163 10 ( ( -LRB- cord-005453-4057qib7 163 11 1pt 1pt JJ cord-005453-4057qib7 163 12 -bacterial -bacterial JJ cord-005453-4057qib7 163 13 sepsis sepsis NN cord-005453-4057qib7 163 14 , , , cord-005453-4057qib7 163 15 1pt 1pt JJ cord-005453-4057qib7 163 16 -ADV -ADV -LRB- cord-005453-4057qib7 163 17 fulminant fulminant JJ cord-005453-4057qib7 163 18 hepatitis hepatitis NN cord-005453-4057qib7 163 19 ) ) -RRB- cord-005453-4057qib7 163 20 , , , cord-005453-4057qib7 164 1 5-years 5-years CD cord-005453-4057qib7 164 2 overall overall RB cord-005453-4057qib7 164 3 pTRM ptrm JJ cord-005453-4057qib7 164 4 at at IN cord-005453-4057qib7 164 5 4 4 CD cord-005453-4057qib7 164 6 years year NNS cord-005453-4057qib7 164 7 was be VBD cord-005453-4057qib7 164 8 13,5 13,5 CD cord-005453-4057qib7 164 9 % % NN cord-005453-4057qib7 164 10 ( ( -LRB- cord-005453-4057qib7 164 11 95%CI:7 95%ci:7 CD cord-005453-4057qib7 164 12 - - SYM cord-005453-4057qib7 164 13 26 26 CD cord-005453-4057qib7 164 14 ) ) -RRB- cord-005453-4057qib7 164 15 . . . cord-005453-4057qib7 165 1 Six six CD cord-005453-4057qib7 165 2 late late JJ cord-005453-4057qib7 165 3 TRM TRM NNP cord-005453-4057qib7 165 4 events event NNS cord-005453-4057qib7 165 5 were be VBD cord-005453-4057qib7 165 6 due due JJ cord-005453-4057qib7 165 7 to to IN cord-005453-4057qib7 165 8 : : : cord-005453-4057qib7 165 9 viral viral JJ cord-005453-4057qib7 165 10 infection infection NN cord-005453-4057qib7 165 11 in in IN cord-005453-4057qib7 165 12 2 2 CD cord-005453-4057qib7 165 13 pts pt NNS cord-005453-4057qib7 165 14 ( ( -LRB- cord-005453-4057qib7 165 15 CMV=1 CMV=1 NNP cord-005453-4057qib7 165 16 , , , cord-005453-4057qib7 165 17 ADV+CMV=1 ADV+CMV=1 NNP cord-005453-4057qib7 165 18 ) ) -RRB- cord-005453-4057qib7 166 1 , , , cord-005453-4057qib7 166 2 bacterial bacterial JJ cord-005453-4057qib7 166 3 sepsis sepsis NN cord-005453-4057qib7 166 4 in in IN cord-005453-4057qib7 166 5 2 2 CD cord-005453-4057qib7 166 6 pts pt NNS cord-005453-4057qib7 166 7 and and CC cord-005453-4057qib7 166 8 2 2 CD cord-005453-4057qib7 166 9 pts pt NNS cord-005453-4057qib7 166 10 had have VBD cord-005453-4057qib7 166 11 bacterial bacterial JJ cord-005453-4057qib7 166 12 and and CC cord-005453-4057qib7 166 13 viral viral JJ cord-005453-4057qib7 166 14 infection infection NN cord-005453-4057qib7 166 15 , , , cord-005453-4057qib7 166 16 all all DT cord-005453-4057qib7 166 17 late late JJ cord-005453-4057qib7 166 18 deaths death NNS cord-005453-4057qib7 166 19 were be VBD cord-005453-4057qib7 166 20 associated associate VBN cord-005453-4057qib7 166 21 with with IN cord-005453-4057qib7 166 22 cGvHD cgvhd NN cord-005453-4057qib7 166 23 and and CC cord-005453-4057qib7 166 24 prolonged prolong VBN cord-005453-4057qib7 166 25 corticosteroid corticosteroid NN cord-005453-4057qib7 166 26 therapy therapy NN cord-005453-4057qib7 166 27 . . . cord-005453-4057qib7 167 1 CI CI NNP cord-005453-4057qib7 167 2 of of IN cord-005453-4057qib7 167 3 acute acute JJ cord-005453-4057qib7 167 4 GvHD GvHD NNP cord-005453-4057qib7 167 5 grades grade NNS cord-005453-4057qib7 167 6 II II NNP cord-005453-4057qib7 167 7 - - HYPH cord-005453-4057qib7 167 8 IV IV NNP cord-005453-4057qib7 167 9 was be VBD cord-005453-4057qib7 167 10 36 36 CD cord-005453-4057qib7 167 11 % % NN cord-005453-4057qib7 167 12 ( ( -LRB- cord-005453-4057qib7 167 13 95 95 CD cord-005453-4057qib7 167 14 % % NN cord-005453-4057qib7 167 15 CI ci NN cord-005453-4057qib7 167 16 : : : cord-005453-4057qib7 167 17 25 25 CD cord-005453-4057qib7 167 18 - - SYM cord-005453-4057qib7 167 19 50 50 CD cord-005453-4057qib7 167 20 ) ) -RRB- cord-005453-4057qib7 167 21 , , , cord-005453-4057qib7 167 22 acute acute JJ cord-005453-4057qib7 167 23 GvHD GvHD NNP cord-005453-4057qib7 167 24 grades grade NNS cord-005453-4057qib7 167 25 III III NNP cord-005453-4057qib7 167 26 - - HYPH cord-005453-4057qib7 167 27 IV IV NNP cord-005453-4057qib7 167 28 3,7 3,7 CD cord-005453-4057qib7 167 29 % % NN cord-005453-4057qib7 167 30 ( ( -LRB- cord-005453-4057qib7 167 31 95 95 CD cord-005453-4057qib7 167 32 % % NN cord-005453-4057qib7 167 33 CI ci NN cord-005453-4057qib7 167 34 : : : cord-005453-4057qib7 167 35 1,5 1,5 CD cord-005453-4057qib7 167 36 - - HYPH cord-005453-4057qib7 167 37 14,5 14,5 CD cord-005453-4057qib7 167 38 ) ) -RRB- cord-005453-4057qib7 167 39 . . . cord-005453-4057qib7 168 1 CI CI NNP cord-005453-4057qib7 168 2 of of IN cord-005453-4057qib7 168 3 cGvHD cGvHD NNP cord-005453-4057qib7 168 4 was be VBD cord-005453-4057qib7 168 5 27%(95%CI:18 27%(95%ci:18 CD cord-005453-4057qib7 168 6 - - SYM cord-005453-4057qib7 168 7 41 41 CD cord-005453-4057qib7 168 8 ) ) -RRB- cord-005453-4057qib7 168 9 . . . cord-005453-4057qib7 169 1 Regimen regimen NN cord-005453-4057qib7 169 2 2 2 CD cord-005453-4057qib7 169 3 was be VBD cord-005453-4057qib7 169 4 more more RBR cord-005453-4057qib7 169 5 effective effective JJ cord-005453-4057qib7 169 6 in in IN cord-005453-4057qib7 169 7 prevention prevention NN cord-005453-4057qib7 169 8 of of IN cord-005453-4057qib7 169 9 aGvHD aGvHD NNP cord-005453-4057qib7 169 10 II II NNP cord-005453-4057qib7 169 11 - - HYPH cord-005453-4057qib7 169 12 IV IV NNP cord-005453-4057qib7 169 13 in in IN cord-005453-4057qib7 169 14 comparison comparison NN cord-005453-4057qib7 169 15 with with IN cord-005453-4057qib7 169 16 regimen regimen NN cord-005453-4057qib7 169 17 1 1 CD cord-005453-4057qib7 169 18 : : SYM cord-005453-4057qib7 169 19 8 8 CD cord-005453-4057qib7 169 20 % % NN cord-005453-4057qib7 169 21 ( ( -LRB- cord-005453-4057qib7 169 22 95 95 CD cord-005453-4057qib7 169 23 % % NN cord-005453-4057qib7 169 24 CI ci NN cord-005453-4057qib7 169 25 : : : cord-005453-4057qib7 169 26 2,2 2,2 CD cord-005453-4057qib7 169 27 - - SYM cord-005453-4057qib7 169 28 30 30 CD cord-005453-4057qib7 169 29 ) ) -RRB- cord-005453-4057qib7 169 30 vs vs IN cord-005453-4057qib7 169 31 45,7 45,7 CD cord-005453-4057qib7 169 32 % % NN cord-005453-4057qib7 169 33 , , , cord-005453-4057qib7 169 34 respectively respectively RB cord-005453-4057qib7 169 35 , , , cord-005453-4057qib7 169 36 p=0,04 p=0,04 NNP cord-005453-4057qib7 169 37 . . . cord-005453-4057qib7 170 1 All all DT cord-005453-4057qib7 170 2 events event NNS cord-005453-4057qib7 170 3 with with IN cord-005453-4057qib7 170 4 acute acute JJ cord-005453-4057qib7 170 5 GvHD GvHD NNP cord-005453-4057qib7 170 6 grades grade NNS cord-005453-4057qib7 170 7 III III NNP cord-005453-4057qib7 170 8 - - HYPH cord-005453-4057qib7 170 9 IV IV NNP cord-005453-4057qib7 170 10 had have VBD cord-005453-4057qib7 170 11 pts pt NNS cord-005453-4057qib7 170 12 with with IN cord-005453-4057qib7 170 13 regimen regimen NN cord-005453-4057qib7 170 14 1 1 CD cord-005453-4057qib7 170 15 . . . cord-005453-4057qib7 171 1 rATG rATG NNP cord-005453-4057qib7 171 2 was be VBD cord-005453-4057qib7 171 3 also also RB cord-005453-4057qib7 171 4 effective effective JJ cord-005453-4057qib7 171 5 in in IN cord-005453-4057qib7 171 6 prevention prevention NN cord-005453-4057qib7 171 7 of of IN cord-005453-4057qib7 171 8 cGvHD cgvhd NN cord-005453-4057qib7 171 9 : : : cord-005453-4057qib7 172 1 CI CI NNP cord-005453-4057qib7 172 2 at at IN cord-005453-4057qib7 172 3 4 4 CD cord-005453-4057qib7 172 4 years year NNS cord-005453-4057qib7 172 5 after after IN cord-005453-4057qib7 172 6 HSCT HSCT NNP cord-005453-4057qib7 172 7 was be VBD cord-005453-4057qib7 172 8 12,5 12,5 CD cord-005453-4057qib7 172 9 % % NN cord-005453-4057qib7 172 10 vs. vs. NN cord-005453-4057qib7 172 11 37 37 CD cord-005453-4057qib7 172 12 % % NN cord-005453-4057qib7 172 13 , , , cord-005453-4057qib7 172 14 respectively respectively RB cord-005453-4057qib7 172 15 , , , cord-005453-4057qib7 172 16 p=0,04 p=0,04 NNP cord-005453-4057qib7 172 17 . . . cord-005453-4057qib7 173 1 Cumulative cumulative JJ cord-005453-4057qib7 173 2 incidence incidence NN cord-005453-4057qib7 173 3 of of IN cord-005453-4057qib7 173 4 relapse relapse NN cord-005453-4057qib7 173 5 was be VBD cord-005453-4057qib7 173 6 25 25 CD cord-005453-4057qib7 173 7 % % NN cord-005453-4057qib7 173 8 ( ( -LRB- cord-005453-4057qib7 173 9 95%CI 95%ci CD cord-005453-4057qib7 173 10 : : : cord-005453-4057qib7 173 11 14 14 CD cord-005453-4057qib7 173 12 - - SYM cord-005453-4057qib7 173 13 50 50 CD cord-005453-4057qib7 173 14 ) ) -RRB- cord-005453-4057qib7 173 15 without without IN cord-005453-4057qib7 173 16 difference difference NN cord-005453-4057qib7 173 17 between between IN cord-005453-4057qib7 173 18 rATG ratg NN cord-005453-4057qib7 173 19 and and CC cord-005453-4057qib7 173 20 hATG hATG VBN cord-005453-4057qib7 173 21 . . . cord-005453-4057qib7 174 1 Event event NN cord-005453-4057qib7 174 2 - - HYPH cord-005453-4057qib7 174 3 free free JJ cord-005453-4057qib7 174 4 survival survival NN cord-005453-4057qib7 174 5 ( ( -LRB- cord-005453-4057qib7 174 6 EFS efs NN cord-005453-4057qib7 174 7 ) ) -RRB- cord-005453-4057qib7 175 1 ( ( -LRB- cord-005453-4057qib7 175 2 event event NN cord-005453-4057qib7 175 3 = = SYM cord-005453-4057qib7 175 4 death death NN cord-005453-4057qib7 175 5 or or CC cord-005453-4057qib7 175 6 relapse relapse NN cord-005453-4057qib7 175 7 ) ) -RRB- cord-005453-4057qib7 175 8 at at IN cord-005453-4057qib7 175 9 4 4 CD cord-005453-4057qib7 175 10 years year NNS cord-005453-4057qib7 175 11 was be VBD cord-005453-4057qib7 175 12 61 61 CD cord-005453-4057qib7 175 13 % % NN cord-005453-4057qib7 175 14 ( ( -LRB- cord-005453-4057qib7 175 15 95%CI 95%ci CD cord-005453-4057qib7 175 16 : : : cord-005453-4057qib7 175 17 48 48 CD cord-005453-4057qib7 175 18 - - SYM cord-005453-4057qib7 175 19 73 73 CD cord-005453-4057qib7 175 20 ) ) -RRB- cord-005453-4057qib7 175 21 , , , cord-005453-4057qib7 175 22 overall overall JJ cord-005453-4057qib7 175 23 survival survival NN cord-005453-4057qib7 175 24 59%(95 59%(95 CD cord-005453-4057qib7 175 25 % % NN cord-005453-4057qib7 175 26 CI:47 CI:47 NNP cord-005453-4057qib7 175 27 - - HYPH cord-005453-4057qib7 175 28 72 72 NNP cord-005453-4057qib7 175 29 ) ) -RRB- cord-005453-4057qib7 175 30 , , , cord-005453-4057qib7 175 31 there there EX cord-005453-4057qib7 175 32 were be VBD cord-005453-4057qib7 175 33 no no DT cord-005453-4057qib7 175 34 difference difference NN cord-005453-4057qib7 175 35 between between IN cord-005453-4057qib7 175 36 age age NN cord-005453-4057qib7 175 37 and and CC cord-005453-4057qib7 175 38 diagnosis diagnosis NN cord-005453-4057qib7 175 39 . . . cord-005453-4057qib7 176 1 Conclusions conclusion NNS cord-005453-4057qib7 176 2 : : : cord-005453-4057qib7 177 1 We -PRON- PRP cord-005453-4057qib7 177 2 confirm confirm VBP cord-005453-4057qib7 177 3 that that IN cord-005453-4057qib7 177 4 the the DT cord-005453-4057qib7 177 5 depletion depletion NN cord-005453-4057qib7 177 6 of of IN cord-005453-4057qib7 177 7 TCRαβ TCRαβ NNP cord-005453-4057qib7 177 8 + + CC cord-005453-4057qib7 178 1 /CD19 /CD19 . cord-005453-4057qib7 179 1 + + CC cord-005453-4057qib7 179 2 T t NN cord-005453-4057qib7 179 3 lymphocytes lymphocyte NNS cord-005453-4057qib7 179 4 from from IN cord-005453-4057qib7 179 5 the the DT cord-005453-4057qib7 179 6 graft graft NN cord-005453-4057qib7 179 7 ensures ensure VBZ cord-005453-4057qib7 179 8 high high JJ cord-005453-4057qib7 179 9 engraftment engraftment NN cord-005453-4057qib7 179 10 rate rate NN cord-005453-4057qib7 179 11 . . . cord-005453-4057qib7 180 1 Transplant transplant NN cord-005453-4057qib7 180 2 - - HYPH cord-005453-4057qib7 180 3 related relate VBN cord-005453-4057qib7 180 4 mortality mortality NN cord-005453-4057qib7 180 5 is be VBZ cord-005453-4057qib7 180 6 caused cause VBN cord-005453-4057qib7 180 7 by by IN cord-005453-4057qib7 180 8 infections infection NNS cord-005453-4057qib7 180 9 , , , cord-005453-4057qib7 180 10 mostly mostly RB cord-005453-4057qib7 180 11 associated associate VBN cord-005453-4057qib7 180 12 with with IN cord-005453-4057qib7 180 13 cases case NNS cord-005453-4057qib7 180 14 of of IN cord-005453-4057qib7 180 15 chronic chronic JJ cord-005453-4057qib7 180 16 GVHD GVHD NNP cord-005453-4057qib7 180 17 . . . cord-005453-4057qib7 181 1 GvHD GvHD NNP cord-005453-4057qib7 181 2 prophylaxis prophylaxis NN cord-005453-4057qib7 181 3 including include VBG cord-005453-4057qib7 181 4 rATG ratg JJ cord-005453-4057qib7 181 5 / / SYM cord-005453-4057qib7 181 6 Rituximab/ Rituximab/ NNP cord-005453-4057qib7 181 7 Bortezomib Bortezomib NNP cord-005453-4057qib7 181 8 improves improve VBZ cord-005453-4057qib7 181 9 GvHD GvHD NNP cord-005453-4057qib7 181 10 control control NN cord-005453-4057qib7 181 11 in in IN cord-005453-4057qib7 181 12 recipients recipient NNS cord-005453-4057qib7 181 13 of of IN cord-005453-4057qib7 181 14 TCRαβ+/CD19+depleted tcrαβ+/cd19+deplete VBN cord-005453-4057qib7 181 15 grafts graft NNS cord-005453-4057qib7 181 16 in in IN cord-005453-4057qib7 181 17 comparison comparison NN cord-005453-4057qib7 181 18 to to IN cord-005453-4057qib7 181 19 hATG/ hATG/ NNP cord-005453-4057qib7 181 20 Tacro Tacro NNP cord-005453-4057qib7 181 21 / / SYM cord-005453-4057qib7 181 22 MTX MTX NNP cord-005453-4057qib7 181 23 apparently apparently RB cord-005453-4057qib7 181 24 without without IN cord-005453-4057qib7 181 25 loss loss NN cord-005453-4057qib7 181 26 of of IN cord-005453-4057qib7 181 27 anti anti JJ cord-005453-4057qib7 181 28 - - JJ cord-005453-4057qib7 181 29 leukemic leukemic JJ cord-005453-4057qib7 181 30 activity activity NN cord-005453-4057qib7 181 31 . . . cord-005453-4057qib7 182 1 Disclosure disclosure NN cord-005453-4057qib7 182 2 Results result NNS cord-005453-4057qib7 182 3 : : : cord-005453-4057qib7 183 1 At at IN cord-005453-4057qib7 183 2 baseline baseline NN cord-005453-4057qib7 183 3 , , , cord-005453-4057qib7 183 4 R r NN cord-005453-4057qib7 183 5 / / SYM cord-005453-4057qib7 183 6 R r NN cord-005453-4057qib7 183 7 ALL all DT cord-005453-4057qib7 183 8 with with IN cord-005453-4057qib7 183 9 EMD EMD NNP cord-005453-4057qib7 183 10 and and CC cord-005453-4057qib7 183 11 LBL LBL NNP cord-005453-4057qib7 183 12 were be VBD cord-005453-4057qib7 183 13 diagnosed diagnose VBN cord-005453-4057qib7 183 14 in in IN cord-005453-4057qib7 183 15 7 7 CD cord-005453-4057qib7 183 16 and and CC cord-005453-4057qib7 183 17 11 11 CD cord-005453-4057qib7 183 18 InO InO NNP cord-005453-4057qib7 183 19 patients patient NNS cord-005453-4057qib7 183 20 and and CC cord-005453-4057qib7 183 21 5 5 CD cord-005453-4057qib7 183 22 and and CC cord-005453-4057qib7 183 23 6 6 CD cord-005453-4057qib7 183 24 SC SC NNP cord-005453-4057qib7 183 25 patients patient NNS cord-005453-4057qib7 183 26 . . . cord-005453-4057qib7 184 1 Median median JJ cord-005453-4057qib7 184 2 ( ( -LRB- cord-005453-4057qib7 184 3 range range NN cord-005453-4057qib7 184 4 ) ) -RRB- cord-005453-4057qib7 184 5 age age NN cord-005453-4057qib7 184 6 of of IN cord-005453-4057qib7 184 7 the the DT cord-005453-4057qib7 184 8 InO InO NNP cord-005453-4057qib7 184 9 and and CC cord-005453-4057qib7 184 10 SC SC NNP cord-005453-4057qib7 184 11 patients patient NNS cord-005453-4057qib7 184 12 was be VBD cord-005453-4057qib7 184 13 55.5 55.5 CD cord-005453-4057qib7 184 14 ( ( -LRB- cord-005453-4057qib7 184 15 20 20 CD cord-005453-4057qib7 184 16 - - SYM cord-005453-4057qib7 184 17 78 78 CD cord-005453-4057qib7 184 18 ) ) -RRB- cord-005453-4057qib7 184 19 and and CC cord-005453-4057qib7 184 20 47.0 47.0 CD cord-005453-4057qib7 184 21 ( ( -LRB- cord-005453-4057qib7 184 22 28 28 CD cord-005453-4057qib7 184 23 - - SYM cord-005453-4057qib7 184 24 64 64 CD cord-005453-4057qib7 184 25 ) ) -RRB- cord-005453-4057qib7 184 26 years year NNS cord-005453-4057qib7 184 27 , , , cord-005453-4057qib7 184 28 with with IN cord-005453-4057qib7 184 29 8/18 8/18 CD cord-005453-4057qib7 184 30 ( ( -LRB- cord-005453-4057qib7 184 31 44.4 44.4 CD cord-005453-4057qib7 184 32 % % NN cord-005453-4057qib7 184 33 ) ) -RRB- cord-005453-4057qib7 184 34 and and CC cord-005453-4057qib7 184 35 8/11 8/11 CD cord-005453-4057qib7 184 36 ( ( -LRB- cord-005453-4057qib7 184 37 72.7 72.7 CD cord-005453-4057qib7 184 38 % % NN cord-005453-4057qib7 184 39 ) ) -RRB- cord-005453-4057qib7 184 40 males male NNS cord-005453-4057qib7 184 41 , , , cord-005453-4057qib7 184 42 respectively respectively RB cord-005453-4057qib7 184 43 . . . cord-005453-4057qib7 185 1 The the DT cord-005453-4057qib7 185 2 rate rate NN cord-005453-4057qib7 185 3 of of IN cord-005453-4057qib7 185 4 CR cr NN cord-005453-4057qib7 185 5 / / SYM cord-005453-4057qib7 185 6 CRi CRi NNS cord-005453-4057qib7 185 7 was be VBD cord-005453-4057qib7 185 8 significantly significantly RB cord-005453-4057qib7 185 9 higher high JJR cord-005453-4057qib7 185 10 in in IN cord-005453-4057qib7 185 11 the the DT cord-005453-4057qib7 185 12 InO InO NNP cord-005453-4057qib7 185 13 group group NN cord-005453-4057qib7 185 14 ( ( -LRB- cord-005453-4057qib7 185 15 12/18 12/18 CD cord-005453-4057qib7 185 16 [ [ -LRB- cord-005453-4057qib7 185 17 66.7 66.7 CD cord-005453-4057qib7 185 18 % % NN cord-005453-4057qib7 185 19 ] ] -RRB- cord-005453-4057qib7 185 20 , , , cord-005453-4057qib7 185 21 95 95 CD cord-005453-4057qib7 185 22 % % NN cord-005453-4057qib7 185 23 confidence confidence NN cord-005453-4057qib7 185 24 interval interval NN cord-005453-4057qib7 185 25 [ [ -LRB- cord-005453-4057qib7 185 26 CI CI NNP cord-005453-4057qib7 185 27 ] ] -RRB- cord-005453-4057qib7 185 28 : : : cord-005453-4057qib7 185 29 41.0 41.0 CD cord-005453-4057qib7 185 30 - - HYPH cord-005453-4057qib7 185 31 86.7 86.7 CD cord-005453-4057qib7 185 32 ) ) -RRB- cord-005453-4057qib7 185 33 compared compare VBN cord-005453-4057qib7 185 34 with with IN cord-005453-4057qib7 185 35 SC SC NNP cord-005453-4057qib7 185 36 ( ( -LRB- cord-005453-4057qib7 185 37 2/11 2/11 CD cord-005453-4057qib7 185 38 [ [ -LRB- cord-005453-4057qib7 185 39 18.2 18.2 CD cord-005453-4057qib7 185 40 % % NN cord-005453-4057qib7 185 41 ] ] -RRB- cord-005453-4057qib7 185 42 , , , cord-005453-4057qib7 185 43 95 95 CD cord-005453-4057qib7 185 44 % % NN cord-005453-4057qib7 185 45 CI ci NN cord-005453-4057qib7 185 46 : : : cord-005453-4057qib7 185 47 2.3 2.3 CD cord-005453-4057qib7 185 48 - - SYM cord-005453-4057qib7 185 49 51.8 51.8 CD cord-005453-4057qib7 185 50 ; ; : cord-005453-4057qib7 185 51 P=0.0144 p=0.0144 NN cord-005453-4057qib7 185 52 ) ) -RRB- cord-005453-4057qib7 185 53 ( ( -LRB- cord-005453-4057qib7 185 54 Table table NN cord-005453-4057qib7 185 55 ) ) -RRB- cord-005453-4057qib7 185 56 . . . cord-005453-4057qib7 186 1 Allogeneic allogeneic IN cord-005453-4057qib7 186 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 186 3 stem stem NN cord-005453-4057qib7 186 4 cell cell NN cord-005453-4057qib7 186 5 transplantation transplantation NN cord-005453-4057qib7 186 6 was be VBD cord-005453-4057qib7 186 7 carried carry VBN cord-005453-4057qib7 186 8 out out RP cord-005453-4057qib7 186 9 in in IN cord-005453-4057qib7 186 10 6/ 6/ CD cord-005453-4057qib7 186 11 18 18 CD cord-005453-4057qib7 186 12 ( ( -LRB- cord-005453-4057qib7 186 13 33.3 33.3 CD cord-005453-4057qib7 186 14 % % NN cord-005453-4057qib7 186 15 ) ) -RRB- cord-005453-4057qib7 187 1 InO InO NNP cord-005453-4057qib7 187 2 and and CC cord-005453-4057qib7 187 3 2/11 2/11 CD cord-005453-4057qib7 187 4 ( ( -LRB- cord-005453-4057qib7 187 5 18.2 18.2 CD cord-005453-4057qib7 187 6 % % NN cord-005453-4057qib7 187 7 ) ) -RRB- cord-005453-4057qib7 188 1 SC SC NNP cord-005453-4057qib7 188 2 patients patient NNS cord-005453-4057qib7 188 3 prior prior RB cord-005453-4057qib7 188 4 to to IN cord-005453-4057qib7 188 5 any any DT cord-005453-4057qib7 188 6 post post JJ cord-005453-4057qib7 188 7 - - JJ cord-005453-4057qib7 188 8 study study JJ cord-005453-4057qib7 188 9 induction induction NN cord-005453-4057qib7 188 10 therapy therapy NN cord-005453-4057qib7 188 11 . . . cord-005453-4057qib7 189 1 The the DT cord-005453-4057qib7 189 2 PFS PFS NNP cord-005453-4057qib7 189 3 hazard hazard NN cord-005453-4057qib7 189 4 ratio ratio NN cord-005453-4057qib7 189 5 [ [ -LRB- cord-005453-4057qib7 189 6 HR HR NNP cord-005453-4057qib7 189 7 ] ] -RRB- cord-005453-4057qib7 189 8 was be VBD cord-005453-4057qib7 189 9 0.502 0.502 CD cord-005453-4057qib7 189 10 ( ( -LRB- cord-005453-4057qib7 189 11 97.5 97.5 CD cord-005453-4057qib7 189 12 % % NN cord-005453-4057qib7 189 13 CI CI NNP cord-005453-4057qib7 189 14 : : : cord-005453-4057qib7 189 15 0.203 0.203 CD cord-005453-4057qib7 189 16 - - HYPH cord-005453-4057qib7 189 17 1.240 1.240 CD cord-005453-4057qib7 189 18 ; ; : cord-005453-4057qib7 189 19 P=0.0410 P=0.0410 NNP cord-005453-4057qib7 189 20 ) ) -RRB- cord-005453-4057qib7 189 21 , , , cord-005453-4057qib7 189 22 with with IN cord-005453-4057qib7 189 23 median median JJ cord-005453-4057qib7 189 24 PFS PFS NNP cord-005453-4057qib7 189 25 of of IN cord-005453-4057qib7 189 26 4.4 4.4 CD cord-005453-4057qib7 189 27 ( ( -LRB- cord-005453-4057qib7 189 28 95 95 CD cord-005453-4057qib7 189 29 % % NN cord-005453-4057qib7 189 30 CI ci NN cord-005453-4057qib7 189 31 : : : cord-005453-4057qib7 189 32 1.9 1.9 CD cord-005453-4057qib7 189 33 - - HYPH cord-005453-4057qib7 189 34 7.1 7.1 CD cord-005453-4057qib7 189 35 ) ) -RRB- cord-005453-4057qib7 189 36 months month NNS cord-005453-4057qib7 189 37 among among IN cord-005453-4057qib7 189 38 InO InO NNP cord-005453-4057qib7 189 39 and and CC cord-005453-4057qib7 189 40 1.6 1.6 CD cord-005453-4057qib7 189 41 ( ( -LRB- cord-005453-4057qib7 189 42 95 95 CD cord-005453-4057qib7 189 43 % % NN cord-005453-4057qib7 190 1 CI CI NNP cord-005453-4057qib7 190 2 : : : cord-005453-4057qib7 190 3 0.8 0.8 CD cord-005453-4057qib7 190 4 - - HYPH cord-005453-4057qib7 190 5 3.7 3.7 CD cord-005453-4057qib7 190 6 ) ) -RRB- cord-005453-4057qib7 190 7 months month NNS cord-005453-4057qib7 190 8 in in IN cord-005453-4057qib7 190 9 SC SC NNP cord-005453-4057qib7 190 10 patients patient NNS cord-005453-4057qib7 190 11 . . . cord-005453-4057qib7 191 1 The the DT cord-005453-4057qib7 191 2 OS OS NNP cord-005453-4057qib7 191 3 HR HR NNP cord-005453-4057qib7 191 4 was be VBD cord-005453-4057qib7 191 5 0.661 0.661 CD cord-005453-4057qib7 192 1 ( ( -LRB- cord-005453-4057qib7 192 2 97.5 97.5 CD cord-005453-4057qib7 192 3 % % NN cord-005453-4057qib7 192 4 CI CI NNP cord-005453-4057qib7 192 5 : : : cord-005453-4057qib7 192 6 0.269 0.269 CD cord-005453-4057qib7 192 7 - - HYPH cord-005453-4057qib7 192 8 1.621 1.621 CD cord-005453-4057qib7 192 9 ; ; : cord-005453-4057qib7 192 10 P=0.1478 P=0.1478 NNP cord-005453-4057qib7 192 11 ) ) -RRB- cord-005453-4057qib7 192 12 , , , cord-005453-4057qib7 192 13 with with IN cord-005453-4057qib7 192 14 median median JJ cord-005453-4057qib7 192 15 OS os NN cord-005453-4057qib7 192 16 of of IN cord-005453-4057qib7 192 17 5.9 5.9 CD cord-005453-4057qib7 192 18 ( ( -LRB- cord-005453-4057qib7 192 19 95 95 CD cord-005453-4057qib7 192 20 % % NN cord-005453-4057qib7 192 21 CI ci NN cord-005453-4057qib7 192 22 : : : cord-005453-4057qib7 192 23 3.4 3.4 CD cord-005453-4057qib7 192 24 - - SYM cord-005453-4057qib7 192 25 9.4 9.4 CD cord-005453-4057qib7 192 26 ) ) -RRB- cord-005453-4057qib7 192 27 months month NNS cord-005453-4057qib7 192 28 in in IN cord-005453-4057qib7 192 29 InO InO NNP cord-005453-4057qib7 192 30 versus versus IN cord-005453-4057qib7 192 31 5.5 5.5 CD cord-005453-4057qib7 192 32 ( ( -LRB- cord-005453-4057qib7 192 33 95 95 CD cord-005453-4057qib7 192 34 % % NN cord-005453-4057qib7 192 35 CI ci NN cord-005453-4057qib7 192 36 : : : cord-005453-4057qib7 192 37 2.1 2.1 CD cord-005453-4057qib7 192 38 - - SYM cord-005453-4057qib7 192 39 6.7 6.7 CD cord-005453-4057qib7 192 40 ) ) -RRB- cord-005453-4057qib7 192 41 months month NNS cord-005453-4057qib7 192 42 in in IN cord-005453-4057qib7 192 43 SC SC NNP cord-005453-4057qib7 192 44 patients patient NNS cord-005453-4057qib7 192 45 ( ( -LRB- cord-005453-4057qib7 192 46 Figure figure NN cord-005453-4057qib7 192 47 ) ) -RRB- cord-005453-4057qib7 192 48 . . . cord-005453-4057qib7 193 1 All all DT cord-005453-4057qib7 193 2 patients patient NNS cord-005453-4057qib7 193 3 had have VBD cord-005453-4057qib7 193 4 adverse adverse JJ cord-005453-4057qib7 193 5 events event NNS cord-005453-4057qib7 193 6 ( ( -LRB- cord-005453-4057qib7 193 7 AEs AEs NNP cord-005453-4057qib7 193 8 ) ) -RRB- cord-005453-4057qib7 193 9 . . . cord-005453-4057qib7 194 1 Serious serious JJ cord-005453-4057qib7 194 2 AEs AEs NNPS cord-005453-4057qib7 194 3 occurred occur VBD cord-005453-4057qib7 194 4 in in IN cord-005453-4057qib7 194 5 10/18 10/18 CD cord-005453-4057qib7 194 6 ( ( -LRB- cord-005453-4057qib7 194 7 55.6 55.6 CD cord-005453-4057qib7 194 8 % % NN cord-005453-4057qib7 194 9 ) ) -RRB- cord-005453-4057qib7 195 1 InO InO NNP cord-005453-4057qib7 195 2 and and CC cord-005453-4057qib7 195 3 5/11 5/11 CD cord-005453-4057qib7 195 4 ( ( -LRB- cord-005453-4057qib7 195 5 45.5 45.5 CD cord-005453-4057qib7 195 6 % % NN cord-005453-4057qib7 195 7 ) ) -RRB- cord-005453-4057qib7 196 1 SC SC NNP cord-005453-4057qib7 196 2 patients patient NNS cord-005453-4057qib7 196 3 ; ; : cord-005453-4057qib7 196 4 4 4 CD cord-005453-4057qib7 196 5 ( ( -LRB- cord-005453-4057qib7 196 6 22.2 22.2 CD cord-005453-4057qib7 196 7 % % NN cord-005453-4057qib7 196 8 ) ) -RRB- cord-005453-4057qib7 196 9 InO ino NN cord-005453-4057qib7 196 10 and and CC cord-005453-4057qib7 196 11 0 0 CD cord-005453-4057qib7 196 12 SC SC NNP cord-005453-4057qib7 196 13 patients patient NNS cord-005453-4057qib7 196 14 had have VBD cord-005453-4057qib7 196 15 grade grade NN cord-005453-4057qib7 196 16 5 5 CD cord-005453-4057qib7 196 17 AE AE NNP cord-005453-4057qib7 196 18 . . . cord-005453-4057qib7 197 1 One one CD cord-005453-4057qib7 197 2 ( ( -LRB- cord-005453-4057qib7 197 3 1/15 1/15 CD cord-005453-4057qib7 197 4 , , , cord-005453-4057qib7 197 5 6 6 CD cord-005453-4057qib7 197 6 .7 .7 CD cord-005453-4057qib7 197 7 % % NN cord-005453-4057qib7 197 8 ) ) -RRB- cord-005453-4057qib7 198 1 patient patient JJ cord-005453-4057qib7 198 2 in in IN cord-005453-4057qib7 198 3 the the DT cord-005453-4057qib7 198 4 InO InO NNP cord-005453-4057qib7 198 5 group group NN cord-005453-4057qib7 198 6 died die VBD cord-005453-4057qib7 198 7 from from IN cord-005453-4057qib7 198 8 veno veno NNP cord-005453-4057qib7 198 9 occlusive occlusive JJ cord-005453-4057qib7 198 10 disease disease NN cord-005453-4057qib7 198 11 . . . cord-005453-4057qib7 199 1 Conclusions conclusion NNS cord-005453-4057qib7 199 2 : : : cord-005453-4057qib7 200 1 Among among IN cord-005453-4057qib7 201 1 R r NN cord-005453-4057qib7 201 2 / / SYM cord-005453-4057qib7 201 3 R r NN cord-005453-4057qib7 201 4 ALL all DT cord-005453-4057qib7 201 5 patients patient NNS cord-005453-4057qib7 201 6 with with IN cord-005453-4057qib7 201 7 EMD EMD NNP cord-005453-4057qib7 201 8 and and CC cord-005453-4057qib7 201 9 LBL LBL NNP cord-005453-4057qib7 201 10 , , , cord-005453-4057qib7 201 11 improvement improvement NN cord-005453-4057qib7 201 12 in in IN cord-005453-4057qib7 201 13 remission remission NN cord-005453-4057qib7 201 14 rates rate NNS cord-005453-4057qib7 201 15 , , , cord-005453-4057qib7 201 16 transplant transplant NN cord-005453-4057qib7 201 17 rates rate NNS cord-005453-4057qib7 201 18 , , , cord-005453-4057qib7 201 19 and and CC cord-005453-4057qib7 201 20 progression progression NN cord-005453-4057qib7 201 21 free free JJ cord-005453-4057qib7 201 22 survival survival NN cord-005453-4057qib7 201 23 was be VBD cord-005453-4057qib7 201 24 shown show VBN cord-005453-4057qib7 201 25 in in IN cord-005453-4057qib7 201 26 the the DT cord-005453-4057qib7 201 27 InO InO NNP cord-005453-4057qib7 201 28 group group NNP cord-005453-4057qib7 201 29 versus versus IN cord-005453-4057qib7 201 30 the the DT cord-005453-4057qib7 201 31 SC SC NNP cord-005453-4057qib7 201 32 group group NN cord-005453-4057qib7 201 33 . . . cord-005453-4057qib7 202 1 Although although IN cord-005453-4057qib7 202 2 patient patient JJ cord-005453-4057qib7 202 3 numbers number NNS cord-005453-4057qib7 202 4 were be VBD cord-005453-4057qib7 202 5 small small JJ cord-005453-4057qib7 202 6 and and CC cord-005453-4057qib7 202 7 limited limit VBD cord-005453-4057qib7 202 8 the the DT cord-005453-4057qib7 202 9 ability ability NN cord-005453-4057qib7 202 10 for for IN cord-005453-4057qib7 202 11 a a DT cord-005453-4057qib7 202 12 robust robust JJ cord-005453-4057qib7 202 13 comparison comparison NN cord-005453-4057qib7 202 14 , , , cord-005453-4057qib7 202 15 these these DT cord-005453-4057qib7 202 16 results result NNS cord-005453-4057qib7 202 17 support support VBP cord-005453-4057qib7 202 18 the the DT cord-005453-4057qib7 202 19 use use NN cord-005453-4057qib7 202 20 of of IN cord-005453-4057qib7 202 21 InO ino NN cord-005453-4057qib7 202 22 in in IN cord-005453-4057qib7 202 23 patients patient NNS cord-005453-4057qib7 202 24 in in IN cord-005453-4057qib7 202 25 this this DT cord-005453-4057qib7 202 26 difficult difficult JJ cord-005453-4057qib7 202 27 to to TO cord-005453-4057qib7 202 28 treat treat VB cord-005453-4057qib7 202 29 population population NN cord-005453-4057qib7 202 30 with with IN cord-005453-4057qib7 202 31 R r NN cord-005453-4057qib7 202 32 / / SYM cord-005453-4057qib7 202 33 R r NN cord-005453-4057qib7 202 34 ALL ALL NNP cord-005453-4057qib7 202 35 and and CC cord-005453-4057qib7 202 36 EMD EMD NNP cord-005453-4057qib7 202 37 or or CC cord-005453-4057qib7 202 38 LBL LBL NNP cord-005453-4057qib7 202 39 . . . cord-005453-4057qib7 203 1 Background background NN cord-005453-4057qib7 203 2 : : : cord-005453-4057qib7 203 3 BCR BCR NNP cord-005453-4057qib7 203 4 - - HYPH cord-005453-4057qib7 203 5 ABL ABL NNP cord-005453-4057qib7 203 6 - - HYPH cord-005453-4057qib7 203 7 targeted target VBN cord-005453-4057qib7 203 8 tyrosine tyrosine NN cord-005453-4057qib7 203 9 kinase kinase NN cord-005453-4057qib7 203 10 inhibitors inhibitor NNS cord-005453-4057qib7 203 11 ( ( -LRB- cord-005453-4057qib7 203 12 TKI TKI NNP cord-005453-4057qib7 203 13 ) ) -RRB- cord-005453-4057qib7 203 14 revolutionized revolutionize VBD cord-005453-4057qib7 203 15 the the DT cord-005453-4057qib7 203 16 outcome outcome NN cord-005453-4057qib7 203 17 of of IN cord-005453-4057qib7 203 18 patients patient NNS cord-005453-4057qib7 203 19 inflicted inflict VBN cord-005453-4057qib7 203 20 with with IN cord-005453-4057qib7 203 21 Ph+ Ph+ NNP cord-005453-4057qib7 203 22 B b NN cord-005453-4057qib7 203 23 - - , cord-005453-4057qib7 203 24 ALL all DT cord-005453-4057qib7 203 25 . . . cord-005453-4057qib7 204 1 Moreover moreover RB cord-005453-4057qib7 204 2 , , , cord-005453-4057qib7 204 3 addition addition NN cord-005453-4057qib7 204 4 of of IN cord-005453-4057qib7 204 5 TKI TKI NNP cord-005453-4057qib7 204 6 may may MD cord-005453-4057qib7 204 7 be be VB cord-005453-4057qib7 204 8 relevant relevant JJ cord-005453-4057qib7 204 9 strategy strategy NN cord-005453-4057qib7 204 10 for for IN cord-005453-4057qib7 204 11 Ph Ph NNP cord-005453-4057qib7 204 12 - - NNP cord-005453-4057qib7 204 13 like like IN cord-005453-4057qib7 204 14 ALL all DT cord-005453-4057qib7 204 15 patients patient NNS cord-005453-4057qib7 204 16 . . . cord-005453-4057qib7 205 1 Methods method NNS cord-005453-4057qib7 205 2 : : : cord-005453-4057qib7 205 3 We -PRON- PRP cord-005453-4057qib7 205 4 hypothesized hypothesize VBD cord-005453-4057qib7 205 5 that that IN cord-005453-4057qib7 205 6 overcoming overcome VBG cord-005453-4057qib7 205 7 the the DT cord-005453-4057qib7 205 8 BM BM NNP cord-005453-4057qib7 205 9 microenvironment microenvironment NN cord-005453-4057qib7 205 10 - - HYPH cord-005453-4057qib7 205 11 mediated mediate VBN cord-005453-4057qib7 205 12 protection protection NN cord-005453-4057qib7 205 13 of of IN cord-005453-4057qib7 205 14 ALL all DT cord-005453-4057qib7 205 15 cells cell NNS cord-005453-4057qib7 205 16 from from IN cord-005453-4057qib7 205 17 TKI TKI NNP cord-005453-4057qib7 205 18 - - HYPH cord-005453-4057qib7 205 19 mediated mediate VBN cord-005453-4057qib7 205 20 apoptosis apoptosis NN cord-005453-4057qib7 205 21 may may MD cord-005453-4057qib7 205 22 further further RB cord-005453-4057qib7 205 23 enhance enhance VB cord-005453-4057qib7 205 24 the the DT cord-005453-4057qib7 205 25 responsiveness responsiveness NN cord-005453-4057qib7 205 26 to to IN cord-005453-4057qib7 205 27 TKI TKI NNP cord-005453-4057qib7 205 28 therapy therapy NN cord-005453-4057qib7 205 29 . . . cord-005453-4057qib7 206 1 Results result NNS cord-005453-4057qib7 206 2 : : : cord-005453-4057qib7 207 1 In in IN cord-005453-4057qib7 207 2 vitro vitro FW cord-005453-4057qib7 207 3 treatment treatment NN cord-005453-4057qib7 207 4 of of IN cord-005453-4057qib7 207 5 BCR BCR NNP cord-005453-4057qib7 207 6 - - HYPH cord-005453-4057qib7 207 7 ABL ABL NNP cord-005453-4057qib7 207 8 - - HYPH cord-005453-4057qib7 207 9 positive positive JJ cord-005453-4057qib7 207 10 ALL all DT cord-005453-4057qib7 207 11 cell cell NN cord-005453-4057qib7 207 12 lines line NNS cord-005453-4057qib7 207 13 NALM1 NALM1 NNP cord-005453-4057qib7 207 14 and and CC cord-005453-4057qib7 207 15 NALM20 NALM20 NNP cord-005453-4057qib7 207 16 ) ) -RRB- cord-005453-4057qib7 207 17 with with IN cord-005453-4057qib7 207 18 dasatinib dasatinib NNP cord-005453-4057qib7 207 19 resulted result VBD cord-005453-4057qib7 207 20 in in IN cord-005453-4057qib7 207 21 significant significant JJ cord-005453-4057qib7 207 22 dose dose NN cord-005453-4057qib7 207 23 - - HYPH cord-005453-4057qib7 207 24 dependent dependent JJ cord-005453-4057qib7 207 25 cell cell NN cord-005453-4057qib7 207 26 growth growth NN cord-005453-4057qib7 207 27 inhibition inhibition NN cord-005453-4057qib7 207 28 , , , cord-005453-4057qib7 207 29 with with IN cord-005453-4057qib7 207 30 IC50 IC50 NNP cord-005453-4057qib7 207 31 of of IN cord-005453-4057qib7 207 32 10 10 CD cord-005453-4057qib7 207 33 - - SYM cord-005453-4057qib7 207 34 15 15 CD cord-005453-4057qib7 207 35 nM nm NN cord-005453-4057qib7 207 36 ( ( -LRB- cord-005453-4057qib7 207 37 p p NN cord-005453-4057qib7 207 38 < < XX cord-005453-4057qib7 207 39 0.01 0.01 CD cord-005453-4057qib7 207 40 ) ) -RRB- cord-005453-4057qib7 207 41 . . . cord-005453-4057qib7 208 1 Furthermore furthermore RB cord-005453-4057qib7 208 2 , , , cord-005453-4057qib7 208 3 dasatinib dasatinib NNP cord-005453-4057qib7 208 4 exhibited exhibit VBD cord-005453-4057qib7 208 5 significant significant JJ cord-005453-4057qib7 208 6 growth growth NN cord-005453-4057qib7 208 7 suppression suppression NN cord-005453-4057qib7 208 8 of of IN cord-005453-4057qib7 208 9 BCR BCR NNP cord-005453-4057qib7 208 10 - - HYPH cord-005453-4057qib7 208 11 ABL ABL NNP cord-005453-4057qib7 208 12 -negative -negative NN cord-005453-4057qib7 209 1 ALL all DT cord-005453-4057qib7 209 2 cells cell NNS cord-005453-4057qib7 209 3 ( ( -LRB- cord-005453-4057qib7 209 4 NALM6 nalm6 XX cord-005453-4057qib7 209 5 and and CC cord-005453-4057qib7 209 6 REH REH NNP cord-005453-4057qib7 209 7 ) ) -RRB- cord-005453-4057qib7 209 8 , , , cord-005453-4057qib7 209 9 with with IN cord-005453-4057qib7 209 10 IC50 IC50 NNP cord-005453-4057qib7 209 11 of of IN cord-005453-4057qib7 209 12 250 250 CD cord-005453-4057qib7 209 13 nM nm NN cord-005453-4057qib7 209 14 and and CC cord-005453-4057qib7 209 15 185 185 CD cord-005453-4057qib7 209 16 nM nm NN cord-005453-4057qib7 209 17 , , , cord-005453-4057qib7 209 18 respectively respectively RB cord-005453-4057qib7 209 19 . . . cord-005453-4057qib7 210 1 However however RB cord-005453-4057qib7 210 2 , , , cord-005453-4057qib7 210 3 when when WRB cord-005453-4057qib7 210 4 cocultured coculture VBN cord-005453-4057qib7 210 5 with with IN cord-005453-4057qib7 210 6 bone bone NN cord-005453-4057qib7 210 7 marrow marrow NN cord-005453-4057qib7 210 8 stromal stromal NN cord-005453-4057qib7 210 9 cells cell NNS cord-005453-4057qib7 210 10 ( ( -LRB- cord-005453-4057qib7 210 11 BMSCs bmsc NNS cord-005453-4057qib7 210 12 ) ) -RRB- cord-005453-4057qib7 210 13 , , , cord-005453-4057qib7 210 14 dasatinib dasatinib NN cord-005453-4057qib7 210 15 - - HYPH cord-005453-4057qib7 210 16 mediated mediate VBN cord-005453-4057qib7 210 17 effect effect NN cord-005453-4057qib7 210 18 was be VBD cord-005453-4057qib7 210 19 abrogated abrogate VBN cord-005453-4057qib7 210 20 in in IN cord-005453-4057qib7 210 21 both both DT cord-005453-4057qib7 210 22 Ph Ph NNP cord-005453-4057qib7 210 23 - - : cord-005453-4057qib7 210 24 and and CC cord-005453-4057qib7 210 25 Ph+ Ph+ NNP cord-005453-4057qib7 210 26 ALL all DT cord-005453-4057qib7 210 27 cells cell NNS cord-005453-4057qib7 210 28 . . . cord-005453-4057qib7 211 1 Furthermore furthermore RB cord-005453-4057qib7 211 2 , , , cord-005453-4057qib7 211 3 dasatinib dasatinib JJ cord-005453-4057qib7 211 4 treatment treatment NN cord-005453-4057qib7 211 5 promoted promote VBD cord-005453-4057qib7 211 6 significant significant JJ cord-005453-4057qib7 211 7 upregulation upregulation NN cord-005453-4057qib7 211 8 of of IN cord-005453-4057qib7 211 9 chemokine chemokine NN cord-005453-4057qib7 211 10 receptor receptor NN cord-005453-4057qib7 211 11 CXCR4 CXCR4 NNP cord-005453-4057qib7 211 12 , , , cord-005453-4057qib7 211 13 on on IN cord-005453-4057qib7 211 14 both both CC cord-005453-4057qib7 211 15 mRNA mrna NN cord-005453-4057qib7 211 16 and and CC cord-005453-4057qib7 211 17 cell cell NN cord-005453-4057qib7 211 18 surface surface NN cord-005453-4057qib7 211 19 levels level NNS cord-005453-4057qib7 211 20 . . . cord-005453-4057qib7 212 1 Elevated elevated JJ cord-005453-4057qib7 212 2 CXCR4 cxcr4 NN cord-005453-4057qib7 212 3 expression expression NN cord-005453-4057qib7 212 4 was be VBD cord-005453-4057qib7 212 5 accompanied accompany VBN cord-005453-4057qib7 212 6 by by IN cord-005453-4057qib7 212 7 increased increase VBN cord-005453-4057qib7 212 8 responsiveness responsiveness NN cord-005453-4057qib7 212 9 of of IN cord-005453-4057qib7 212 10 ALL all DT cord-005453-4057qib7 212 11 cells cell NNS cord-005453-4057qib7 212 12 to to IN cord-005453-4057qib7 212 13 CXCL12 CXCL12 VBG cord-005453-4057qib7 212 14 stimulation stimulation NN cord-005453-4057qib7 212 15 , , , cord-005453-4057qib7 212 16 resulting result VBG cord-005453-4057qib7 212 17 in in IN cord-005453-4057qib7 212 18 strong strong JJ cord-005453-4057qib7 212 19 and and CC cord-005453-4057qib7 212 20 sustained sustained JJ cord-005453-4057qib7 212 21 phosphorylation phosphorylation NN cord-005453-4057qib7 212 22 of of IN cord-005453-4057qib7 212 23 Erk1/2 Erk1/2 NNP cord-005453-4057qib7 212 24 and and CC cord-005453-4057qib7 212 25 Akt Akt NNP cord-005453-4057qib7 212 26 and and CC cord-005453-4057qib7 212 27 increased increase VBD cord-005453-4057qib7 212 28 adhesion adhesion NN cord-005453-4057qib7 212 29 capacity capacity NN cord-005453-4057qib7 212 30 to to IN cord-005453-4057qib7 212 31 BMSCs bmscs VB cord-005453-4057qib7 212 32 . . . cord-005453-4057qib7 213 1 Therefore therefore RB cord-005453-4057qib7 213 2 , , , cord-005453-4057qib7 213 3 dasatinib dasatinib NN cord-005453-4057qib7 213 4 - - HYPH cord-005453-4057qib7 213 5 induced induce VBN cord-005453-4057qib7 213 6 upregulation upregulation NN cord-005453-4057qib7 213 7 of of IN cord-005453-4057qib7 213 8 CXCR4 cxcr4 NN cord-005453-4057qib7 213 9 promotes promote VBZ cord-005453-4057qib7 213 10 stroma stroma NN cord-005453-4057qib7 213 11 - - HYPH cord-005453-4057qib7 213 12 mediated mediate VBN cord-005453-4057qib7 213 13 survival survival NN cord-005453-4057qib7 213 14 advantage advantage NN cord-005453-4057qib7 213 15 of of IN cord-005453-4057qib7 213 16 ALL all DT cord-005453-4057qib7 213 17 cells cell NNS cord-005453-4057qib7 213 18 upon upon IN cord-005453-4057qib7 213 19 TKI TKI NNP cord-005453-4057qib7 213 20 therapy therapy NN cord-005453-4057qib7 213 21 . . . cord-005453-4057qib7 214 1 Next next RB cord-005453-4057qib7 214 2 , , , cord-005453-4057qib7 214 3 in in IN cord-005453-4057qib7 214 4 order order NN cord-005453-4057qib7 214 5 to to TO cord-005453-4057qib7 214 6 overcome overcome VB cord-005453-4057qib7 214 7 the the DT cord-005453-4057qib7 214 8 CXCR4-mediated CXCR4-mediated NNP cord-005453-4057qib7 214 9 stromal stromal JJ cord-005453-4057qib7 214 10 protection protection NN cord-005453-4057qib7 214 11 , , , cord-005453-4057qib7 214 12 we -PRON- PRP cord-005453-4057qib7 214 13 choose choose VBP cord-005453-4057qib7 214 14 to to TO cord-005453-4057qib7 214 15 combine combine VB cord-005453-4057qib7 214 16 dasatinib dasatinib NN cord-005453-4057qib7 214 17 with with IN cord-005453-4057qib7 214 18 the the DT cord-005453-4057qib7 214 19 histone histone NN cord-005453-4057qib7 214 20 deacetylase deacetylase NN cord-005453-4057qib7 214 21 inhibitor inhibitor NN cord-005453-4057qib7 214 22 panobinostat panobinostat NNP cord-005453-4057qib7 214 23 , , , cord-005453-4057qib7 214 24 for for IN cord-005453-4057qib7 214 25 its -PRON- PRP$ cord-005453-4057qib7 214 26 known know VBN cord-005453-4057qib7 214 27 ability ability NN cord-005453-4057qib7 214 28 to to TO cord-005453-4057qib7 214 29 deplete deplete VB cord-005453-4057qib7 214 30 CXCR4 CXCR4 NNS cord-005453-4057qib7 214 31 in in IN cord-005453-4057qib7 214 32 AML AML NNP cord-005453-4057qib7 214 33 cells cell NNS cord-005453-4057qib7 214 34 . . . cord-005453-4057qib7 215 1 Single single JJ cord-005453-4057qib7 215 2 - - HYPH cord-005453-4057qib7 215 3 agent agent NN cord-005453-4057qib7 215 4 treatment treatment NN cord-005453-4057qib7 215 5 with with IN cord-005453-4057qib7 215 6 panobinostat panobinostat NNP cord-005453-4057qib7 215 7 demonstrated demonstrate VBD cord-005453-4057qib7 215 8 significant significant JJ cord-005453-4057qib7 215 9 inhibition inhibition NN cord-005453-4057qib7 215 10 of of IN cord-005453-4057qib7 215 11 Ph Ph NNP cord-005453-4057qib7 215 12 - - : cord-005453-4057qib7 215 13 and and CC cord-005453-4057qib7 215 14 Ph+ Ph+ NNP cord-005453-4057qib7 215 15 ALL all DT cord-005453-4057qib7 215 16 cell cell NN cord-005453-4057qib7 215 17 growth growth NN cord-005453-4057qib7 215 18 at at IN cord-005453-4057qib7 215 19 low low JJ cord-005453-4057qib7 215 20 nanomolar nanomolar NNP cord-005453-4057qib7 215 21 concentrations concentration NNS cord-005453-4057qib7 215 22 ( ( -LRB- cord-005453-4057qib7 215 23 p p NN cord-005453-4057qib7 215 24 < < XX cord-005453-4057qib7 215 25 0.01 0.01 CD cord-005453-4057qib7 215 26 ) ) -RRB- cord-005453-4057qib7 215 27 . . . cord-005453-4057qib7 216 1 Importantly importantly RB cord-005453-4057qib7 216 2 , , , cord-005453-4057qib7 216 3 combination combination NN cord-005453-4057qib7 216 4 of of IN cord-005453-4057qib7 216 5 panobinostat panobinostat NN cord-005453-4057qib7 216 6 with with IN cord-005453-4057qib7 216 7 dasatinib dasatinib NNP cord-005453-4057qib7 216 8 synergized synergize VBN cord-005453-4057qib7 216 9 ( ( -LRB- cord-005453-4057qib7 216 10 CI CI NNP cord-005453-4057qib7 216 11 < < XX cord-005453-4057qib7 216 12 0.5 0.5 CD cord-005453-4057qib7 216 13 ) ) -RRB- cord-005453-4057qib7 216 14 , , , cord-005453-4057qib7 216 15 effectively effectively RB cord-005453-4057qib7 216 16 overcoming overcome VBG cord-005453-4057qib7 216 17 the the DT cord-005453-4057qib7 216 18 protection protection NN cord-005453-4057qib7 216 19 provided provide VBN cord-005453-4057qib7 216 20 by by IN cord-005453-4057qib7 216 21 BMSCs bmsc NNS cord-005453-4057qib7 216 22 and and CC cord-005453-4057qib7 216 23 inducing induce VBG cord-005453-4057qib7 216 24 the the DT cord-005453-4057qib7 216 25 apoptosis apoptosis NN cord-005453-4057qib7 216 26 of of IN cord-005453-4057qib7 216 27 Ph Ph NNP cord-005453-4057qib7 216 28 - - : cord-005453-4057qib7 216 29 and and CC cord-005453-4057qib7 216 30 Ph+ Ph+ NNP cord-005453-4057qib7 216 31 ALL all DT cord-005453-4057qib7 216 32 cells cell NNS cord-005453-4057qib7 216 33 , , , cord-005453-4057qib7 216 34 as as IN cord-005453-4057qib7 216 35 demonstrated demonstrate VBN cord-005453-4057qib7 216 36 by by IN cord-005453-4057qib7 216 37 phosphatidylserine phosphatidylserine NN cord-005453-4057qib7 216 38 externalization externalization NN cord-005453-4057qib7 216 39 , , , cord-005453-4057qib7 216 40 mitochondrial mitochondrial JJ cord-005453-4057qib7 216 41 depolarization depolarization NN cord-005453-4057qib7 216 42 and and CC cord-005453-4057qib7 216 43 DNA dna NN cord-005453-4057qib7 216 44 fragmentation fragmentation NN cord-005453-4057qib7 216 45 . . . cord-005453-4057qib7 217 1 Furthermore furthermore RB cord-005453-4057qib7 217 2 , , , cord-005453-4057qib7 217 3 combining combine VBG cord-005453-4057qib7 217 4 panobinostat panobinostat NNP cord-005453-4057qib7 217 5 with with IN cord-005453-4057qib7 217 6 dasatinib dasatinib NNP cord-005453-4057qib7 217 7 significantly significantly RB cord-005453-4057qib7 217 8 reduced reduce VBD cord-005453-4057qib7 217 9 CXCR4 cxcr4 NN cord-005453-4057qib7 217 10 surface surface NN cord-005453-4057qib7 217 11 levels level NNS cord-005453-4057qib7 217 12 in in IN cord-005453-4057qib7 217 13 Ph Ph NNP cord-005453-4057qib7 217 14 - - : cord-005453-4057qib7 217 15 and and CC cord-005453-4057qib7 217 16 Ph+ Ph+ NNP cord-005453-4057qib7 217 17 ALL all DT cord-005453-4057qib7 217 18 cells cell NNS cord-005453-4057qib7 217 19 . . . cord-005453-4057qib7 218 1 Accordingly accordingly RB cord-005453-4057qib7 218 2 , , , cord-005453-4057qib7 218 3 CXCL12mediated cxcl12mediated JJ cord-005453-4057qib7 218 4 responses response NNS cord-005453-4057qib7 218 5 , , , cord-005453-4057qib7 218 6 including include VBG cord-005453-4057qib7 218 7 Erk1/2 Erk1/2 NNP cord-005453-4057qib7 218 8 and and CC cord-005453-4057qib7 218 9 Akt Akt NNP cord-005453-4057qib7 218 10 activation activation NN cord-005453-4057qib7 218 11 and and CC cord-005453-4057qib7 218 12 adhesion adhesion NN cord-005453-4057qib7 218 13 to to IN cord-005453-4057qib7 218 14 BMSCs bmsc NNS cord-005453-4057qib7 218 15 were be VBD cord-005453-4057qib7 218 16 significantly significantly RB cord-005453-4057qib7 218 17 reduced reduce VBN cord-005453-4057qib7 218 18 upon upon IN cord-005453-4057qib7 218 19 combined combine VBN cord-005453-4057qib7 218 20 panobinostat panobinostat NN cord-005453-4057qib7 218 21 / / SYM cord-005453-4057qib7 218 22 dasatinib dasatinib NN cord-005453-4057qib7 218 23 treatment treatment NN cord-005453-4057qib7 218 24 . . . cord-005453-4057qib7 219 1 These these DT cord-005453-4057qib7 219 2 data datum NNS cord-005453-4057qib7 219 3 indicate indicate VBP cord-005453-4057qib7 219 4 that that IN cord-005453-4057qib7 219 5 panobinostat panobinostat NNP cord-005453-4057qib7 219 6 effectively effectively RB cord-005453-4057qib7 219 7 suppresses suppress VBZ cord-005453-4057qib7 219 8 both both DT cord-005453-4057qib7 219 9 basal basal NN cord-005453-4057qib7 219 10 and and CC cord-005453-4057qib7 219 11 dasatinib dasatinib NN cord-005453-4057qib7 219 12 - - HYPH cord-005453-4057qib7 219 13 induced induce VBN cord-005453-4057qib7 219 14 CXCR4 cxcr4 NN cord-005453-4057qib7 219 15 expression expression NN cord-005453-4057qib7 219 16 and and CC cord-005453-4057qib7 219 17 function function NN cord-005453-4057qib7 219 18 in in IN cord-005453-4057qib7 219 19 ALL all DT cord-005453-4057qib7 219 20 cells cell NNS cord-005453-4057qib7 219 21 overcoming overcome VBG cord-005453-4057qib7 219 22 stroma stroma NN cord-005453-4057qib7 219 23 - - HYPH cord-005453-4057qib7 219 24 mediated mediate VBN cord-005453-4057qib7 219 25 resistance resistance NN cord-005453-4057qib7 219 26 to to IN cord-005453-4057qib7 219 27 dasatinib dasatinib NNP cord-005453-4057qib7 219 28 . . . cord-005453-4057qib7 220 1 To to TO cord-005453-4057qib7 220 2 determine determine VB cord-005453-4057qib7 220 3 the the DT cord-005453-4057qib7 220 4 molecular molecular JJ cord-005453-4057qib7 220 5 mechanism mechanism NN cord-005453-4057qib7 220 6 , , , cord-005453-4057qib7 220 7 we -PRON- PRP cord-005453-4057qib7 220 8 performed perform VBD cord-005453-4057qib7 220 9 gene gene NN cord-005453-4057qib7 220 10 and and CC cord-005453-4057qib7 220 11 protein protein NN cord-005453-4057qib7 220 12 expression expression NN cord-005453-4057qib7 220 13 analysis analysis NN cord-005453-4057qib7 220 14 . . . cord-005453-4057qib7 221 1 Panobinostat Panobinostat NNP cord-005453-4057qib7 221 2 , , , cord-005453-4057qib7 221 3 alone alone JJ cord-005453-4057qib7 221 4 or or CC cord-005453-4057qib7 221 5 in in IN cord-005453-4057qib7 221 6 combination combination NN cord-005453-4057qib7 221 7 with with IN cord-005453-4057qib7 221 8 dasatinib dasatinib NN cord-005453-4057qib7 221 9 , , , cord-005453-4057qib7 221 10 significantly significantly RB cord-005453-4057qib7 221 11 down down RB cord-005453-4057qib7 221 12 - - HYPH cord-005453-4057qib7 221 13 regulated regulate VBD cord-005453-4057qib7 221 14 the the DT cord-005453-4057qib7 221 15 protein protein NN cord-005453-4057qib7 221 16 levels level NNS cord-005453-4057qib7 221 17 of of IN cord-005453-4057qib7 221 18 calcineurin calcineurin NN cord-005453-4057qib7 221 19 , , , cord-005453-4057qib7 221 20 a a DT cord-005453-4057qib7 221 21 serine serine NN cord-005453-4057qib7 221 22 - - HYPH cord-005453-4057qib7 221 23 threonine threonine NN cord-005453-4057qib7 221 24 protein protein NN cord-005453-4057qib7 221 25 phosphatase phosphatase NN cord-005453-4057qib7 221 26 previously previously RB cord-005453-4057qib7 221 27 implicated implicate VBN cord-005453-4057qib7 221 28 in in IN cord-005453-4057qib7 221 29 T T NNP cord-005453-4057qib7 221 30 - - HYPH cord-005453-4057qib7 221 31 ALL ALL NNP cord-005453-4057qib7 221 32 and and CC cord-005453-4057qib7 221 33 B b NN cord-005453-4057qib7 221 34 - - : cord-005453-4057qib7 221 35 ALL all DT cord-005453-4057qib7 221 36 pathogenesis pathogenesis NN cord-005453-4057qib7 221 37 , , , cord-005453-4057qib7 221 38 as as RB cord-005453-4057qib7 221 39 well well RB cord-005453-4057qib7 221 40 as as IN cord-005453-4057qib7 221 41 of of IN cord-005453-4057qib7 221 42 NFATc1 NFATc1 NNP cord-005453-4057qib7 221 43 , , , cord-005453-4057qib7 221 44 a a DT cord-005453-4057qib7 221 45 critical critical JJ cord-005453-4057qib7 221 46 effector effector NN cord-005453-4057qib7 221 47 of of IN cord-005453-4057qib7 221 48 the the DT cord-005453-4057qib7 221 49 calcineurin calcineurin NN cord-005453-4057qib7 221 50 signaling signal VBG cord-005453-4057qib7 221 51 cascade cascade NN cord-005453-4057qib7 221 52 , , , cord-005453-4057qib7 221 53 and and CC cord-005453-4057qib7 221 54 NFATc1-regulated nfatc1-regulated JJ cord-005453-4057qib7 221 55 target target NN cord-005453-4057qib7 221 56 genes gene NNS cord-005453-4057qib7 221 57 . . . cord-005453-4057qib7 222 1 It -PRON- PRP cord-005453-4057qib7 222 2 was be VBD cord-005453-4057qib7 222 3 previously previously RB cord-005453-4057qib7 222 4 found find VBN cord-005453-4057qib7 222 5 that that IN cord-005453-4057qib7 222 6 calcineurin calcineurin NN cord-005453-4057qib7 222 7 signaling signal VBG cord-005453-4057qib7 222 8 positively positively RB cord-005453-4057qib7 222 9 regulates regulate VBZ cord-005453-4057qib7 222 10 CXCR4 cxcr4 NN cord-005453-4057qib7 222 11 expression expression NN cord-005453-4057qib7 222 12 in in IN cord-005453-4057qib7 222 13 T t NN cord-005453-4057qib7 222 14 lymphocytes lymphocyte NNS cord-005453-4057qib7 222 15 . . . cord-005453-4057qib7 223 1 Additionally additionally RB cord-005453-4057qib7 223 2 , , , cord-005453-4057qib7 223 3 cyclosporin cyclosporin VB cord-005453-4057qib7 223 4 A a DT cord-005453-4057qib7 223 5 ( ( -LRB- cord-005453-4057qib7 223 6 CsA csa NN cord-005453-4057qib7 223 7 ) ) -RRB- cord-005453-4057qib7 223 8 decreased decrease VBD cord-005453-4057qib7 223 9 both both DT cord-005453-4057qib7 223 10 basal basal NN cord-005453-4057qib7 223 11 and and CC cord-005453-4057qib7 223 12 dasatinib dasatinib NN cord-005453-4057qib7 223 13 - - HYPH cord-005453-4057qib7 223 14 induced induce VBN cord-005453-4057qib7 223 15 CXCR4 cxcr4 NN cord-005453-4057qib7 223 16 surface surface NN cord-005453-4057qib7 223 17 levels level NNS cord-005453-4057qib7 223 18 in in IN cord-005453-4057qib7 223 19 ALL all DT cord-005453-4057qib7 223 20 cells cell NNS cord-005453-4057qib7 223 21 , , , cord-005453-4057qib7 223 22 overcoming overcome VBG cord-005453-4057qib7 223 23 the the DT cord-005453-4057qib7 223 24 protection protection NN cord-005453-4057qib7 223 25 of of IN cord-005453-4057qib7 223 26 the the DT cord-005453-4057qib7 223 27 BMSCs bmsc NNS cord-005453-4057qib7 223 28 which which WDT cord-005453-4057qib7 223 29 result result VBP cord-005453-4057qib7 223 30 in in IN cord-005453-4057qib7 223 31 potentiation potentiation NN cord-005453-4057qib7 223 32 of of IN cord-005453-4057qib7 223 33 the the DT cord-005453-4057qib7 223 34 cytotoxic cytotoxic JJ cord-005453-4057qib7 223 35 effect effect NN cord-005453-4057qib7 223 36 of of IN cord-005453-4057qib7 223 37 dasatininb dasatininb NNP cord-005453-4057qib7 223 38 and and CC cord-005453-4057qib7 223 39 panobinostat panobinostat NNP cord-005453-4057qib7 223 40 . . . cord-005453-4057qib7 224 1 Combining combine VBG cord-005453-4057qib7 224 2 CsA csa NN cord-005453-4057qib7 224 3 with with IN cord-005453-4057qib7 224 4 panobinostat panobinostat NNP cord-005453-4057qib7 224 5 resulted result VBD cord-005453-4057qib7 224 6 in in IN cord-005453-4057qib7 224 7 deeper deep JJR cord-005453-4057qib7 224 8 suppression suppression NN cord-005453-4057qib7 224 9 of of IN cord-005453-4057qib7 224 10 NFATc1-regulated nfatc1-regulated JJ cord-005453-4057qib7 224 11 target target NN cord-005453-4057qib7 224 12 genes gene NNS cord-005453-4057qib7 224 13 . . . cord-005453-4057qib7 225 1 We -PRON- PRP cord-005453-4057qib7 225 2 thus thus RB cord-005453-4057qib7 225 3 link link VBP cord-005453-4057qib7 225 4 the the DT cord-005453-4057qib7 225 5 effect effect NN cord-005453-4057qib7 225 6 of of IN cord-005453-4057qib7 225 7 panobinostat panobinostat NNP cord-005453-4057qib7 225 8 with with IN cord-005453-4057qib7 225 9 calcineurin calcineurin NN cord-005453-4057qib7 225 10 - - HYPH cord-005453-4057qib7 225 11 dependent dependent JJ cord-005453-4057qib7 225 12 downregulation downregulation NN cord-005453-4057qib7 225 13 of of IN cord-005453-4057qib7 225 14 CXCR4 CXCR4 NNS cord-005453-4057qib7 225 15 , , , cord-005453-4057qib7 225 16 blocking block VBG cord-005453-4057qib7 225 17 the the DT cord-005453-4057qib7 225 18 ability ability NN cord-005453-4057qib7 225 19 of of IN cord-005453-4057qib7 225 20 the the DT cord-005453-4057qib7 225 21 leukemic leukemic JJ cord-005453-4057qib7 225 22 cells cell NNS cord-005453-4057qib7 225 23 to to TO cord-005453-4057qib7 225 24 respond respond VB cord-005453-4057qib7 225 25 to to IN cord-005453-4057qib7 225 26 CXCL12mediated cxcl12mediated JJ cord-005453-4057qib7 225 27 stromal stromal JJ cord-005453-4057qib7 225 28 support support NN cord-005453-4057qib7 225 29 . . . cord-005453-4057qib7 226 1 Conclusions conclusion NNS cord-005453-4057qib7 226 2 : : : cord-005453-4057qib7 227 1 Taken take VBN cord-005453-4057qib7 227 2 together together RB cord-005453-4057qib7 227 3 , , , cord-005453-4057qib7 227 4 our -PRON- PRP$ cord-005453-4057qib7 227 5 results result NNS cord-005453-4057qib7 227 6 identify identify VBP cord-005453-4057qib7 227 7 calcineurin calcineurin NN cord-005453-4057qib7 227 8 signaling signal VBG cord-005453-4057qib7 227 9 pathway pathway NN cord-005453-4057qib7 227 10 as as IN cord-005453-4057qib7 227 11 a a DT cord-005453-4057qib7 227 12 novel novel JJ cord-005453-4057qib7 227 13 target target NN cord-005453-4057qib7 227 14 of of IN cord-005453-4057qib7 227 15 panobinostat panobinostat NN cord-005453-4057qib7 227 16 in in IN cord-005453-4057qib7 227 17 ALL all DT cord-005453-4057qib7 227 18 cells cell NNS cord-005453-4057qib7 227 19 and and CC cord-005453-4057qib7 227 20 indicate indicate VBP cord-005453-4057qib7 227 21 that that IN cord-005453-4057qib7 227 22 HDAC HDAC NNP cord-005453-4057qib7 227 23 inhibition inhibition NN cord-005453-4057qib7 227 24 with with IN cord-005453-4057qib7 227 25 panobinostat panobinostat NNP cord-005453-4057qib7 227 26 may may MD cord-005453-4057qib7 227 27 be be VB cord-005453-4057qib7 227 28 effective effective JJ cord-005453-4057qib7 227 29 strategy strategy NN cord-005453-4057qib7 227 30 for for IN cord-005453-4057qib7 227 31 facilitating facilitate VBG cord-005453-4057qib7 227 32 the the DT cord-005453-4057qib7 227 33 anti anti JJ cord-005453-4057qib7 227 34 - - JJ cord-005453-4057qib7 227 35 leukemic leukemic JJ cord-005453-4057qib7 227 36 activity activity NN cord-005453-4057qib7 227 37 of of IN cord-005453-4057qib7 227 38 TKI TKI NNP cord-005453-4057qib7 227 39 therapy therapy NN cord-005453-4057qib7 227 40 . . . cord-005453-4057qib7 228 1 Disclosure disclosure NN cord-005453-4057qib7 228 2 : : : cord-005453-4057qib7 228 3 nothing nothing NN cord-005453-4057qib7 228 4 to to TO cord-005453-4057qib7 228 5 disclose disclose VB cord-005453-4057qib7 228 6 Background background NN cord-005453-4057qib7 228 7 : : : cord-005453-4057qib7 229 1 The the DT cord-005453-4057qib7 229 2 treatment treatment NN cord-005453-4057qib7 229 3 of of IN cord-005453-4057qib7 229 4 relapsed relapse VBN cord-005453-4057qib7 229 5 / / SYM cord-005453-4057qib7 229 6 refractory refractory JJ cord-005453-4057qib7 229 7 acute acute JJ cord-005453-4057qib7 229 8 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 229 9 leukemia leukemia NN cord-005453-4057qib7 229 10 ( ( -LRB- cord-005453-4057qib7 229 11 RR rr NN cord-005453-4057qib7 229 12 - - HYPH cord-005453-4057qib7 229 13 ALL ALL NNP cord-005453-4057qib7 229 14 ) ) -RRB- cord-005453-4057qib7 229 15 remains remain VBZ cord-005453-4057qib7 229 16 a a DT cord-005453-4057qib7 229 17 clinical clinical JJ cord-005453-4057qib7 229 18 challenge challenge NN cord-005453-4057qib7 229 19 with with IN cord-005453-4057qib7 229 20 a a DT cord-005453-4057qib7 229 21 generally generally RB cord-005453-4057qib7 229 22 dismal dismal JJ cord-005453-4057qib7 229 23 prognosis prognosis NN cord-005453-4057qib7 229 24 . . . cord-005453-4057qib7 230 1 Allo Allo NNP cord-005453-4057qib7 230 2 - - HYPH cord-005453-4057qib7 230 3 SCT SCT NNP cord-005453-4057qib7 230 4 using use VBG cord-005453-4057qib7 230 5 a a DT cord-005453-4057qib7 230 6 sequential sequential JJ cord-005453-4057qib7 230 7 conditioning conditioning NN cord-005453-4057qib7 230 8 ( ( -LRB- cord-005453-4057qib7 230 9 " " `` cord-005453-4057qib7 230 10 FLAMSA"-like flamsa"-like IN cord-005453-4057qib7 230 11 regimen regimen NN cord-005453-4057qib7 230 12 ) ) -RRB- cord-005453-4057qib7 230 13 has have VBZ cord-005453-4057qib7 230 14 shown show VBN cord-005453-4057qib7 230 15 promising promising JJ cord-005453-4057qib7 230 16 results result NNS cord-005453-4057qib7 230 17 in in IN cord-005453-4057qib7 230 18 relapsed relapse VBN cord-005453-4057qib7 230 19 / / SYM cord-005453-4057qib7 230 20 refractory refractory JJ cord-005453-4057qib7 230 21 AML AML NNP cord-005453-4057qib7 230 22 , , , cord-005453-4057qib7 230 23 but but CC cord-005453-4057qib7 230 24 little little JJ cord-005453-4057qib7 230 25 is be VBZ cord-005453-4057qib7 230 26 known know VBN cord-005453-4057qib7 230 27 about about IN cord-005453-4057qib7 230 28 the the DT cord-005453-4057qib7 230 29 efficacy efficacy NN cord-005453-4057qib7 230 30 of of IN cord-005453-4057qib7 230 31 this this DT cord-005453-4057qib7 230 32 procedure procedure NN cord-005453-4057qib7 230 33 in in IN cord-005453-4057qib7 230 34 RR rr NN cord-005453-4057qib7 230 35 - - HYPH cord-005453-4057qib7 230 36 ALL ALL NNP cord-005453-4057qib7 230 37 . . . cord-005453-4057qib7 231 1 Methods method NNS cord-005453-4057qib7 231 2 : : : cord-005453-4057qib7 231 3 We -PRON- PRP cord-005453-4057qib7 231 4 identified identify VBD cord-005453-4057qib7 231 5 115 115 CD cord-005453-4057qib7 231 6 adult adult NN cord-005453-4057qib7 231 7 patients patient NNS cord-005453-4057qib7 231 8 ( ( -LRB- cord-005453-4057qib7 231 9 45 45 CD cord-005453-4057qib7 231 10 % % NN cord-005453-4057qib7 231 11 females female NNS cord-005453-4057qib7 231 12 ; ; : cord-005453-4057qib7 231 13 median median JJ cord-005453-4057qib7 231 14 age age NN cord-005453-4057qib7 231 15 : : : cord-005453-4057qib7 231 16 38 38 CD cord-005453-4057qib7 231 17 y y NN cord-005453-4057qib7 231 18 ; ; : cord-005453-4057qib7 231 19 range range NN cord-005453-4057qib7 231 20 , , , cord-005453-4057qib7 231 21 18 18 CD cord-005453-4057qib7 231 22 - - SYM cord-005453-4057qib7 231 23 66 66 CD cord-005453-4057qib7 231 24 ) ) -RRB- cord-005453-4057qib7 231 25 with with IN cord-005453-4057qib7 231 26 ALL all DT cord-005453-4057qib7 231 27 in in IN cord-005453-4057qib7 231 28 primary primary JJ cord-005453-4057qib7 231 29 refractory refractory JJ cord-005453-4057qib7 231 30 phase phase NN cord-005453-4057qib7 231 31 ( ( -LRB- cord-005453-4057qib7 231 32 26 26 CD cord-005453-4057qib7 231 33 % % NN cord-005453-4057qib7 231 34 ) ) -RRB- cord-005453-4057qib7 231 35 or or CC cord-005453-4057qib7 231 36 in in IN cord-005453-4057qib7 231 37 relapse relapse NN cord-005453-4057qib7 231 38 ( ( -LRB- cord-005453-4057qib7 231 39 74 74 CD cord-005453-4057qib7 231 40 % % NN cord-005453-4057qib7 231 41 ) ) -RRB- cord-005453-4057qib7 231 42 , , , cord-005453-4057qib7 231 43 allografted allografte VBN cord-005453-4057qib7 231 44 between between IN cord-005453-4057qib7 231 45 2000 2000 CD cord-005453-4057qib7 231 46 and and CC cord-005453-4057qib7 231 47 2017 2017 CD cord-005453-4057qib7 231 48 from from IN cord-005453-4057qib7 231 49 a a DT cord-005453-4057qib7 231 50 matched match VBN cord-005453-4057qib7 231 51 sibling sibling NN cord-005453-4057qib7 231 52 ( ( -LRB- cord-005453-4057qib7 231 53 31 31 CD cord-005453-4057qib7 231 54 % % NN cord-005453-4057qib7 231 55 ) ) -RRB- cord-005453-4057qib7 231 56 , , , cord-005453-4057qib7 231 57 matched match VBN cord-005453-4057qib7 231 58 unrelated unrelated JJ cord-005453-4057qib7 231 59 ( ( -LRB- cord-005453-4057qib7 231 60 58 58 CD cord-005453-4057qib7 231 61 % % NN cord-005453-4057qib7 231 62 ) ) -RRB- cord-005453-4057qib7 231 63 or or CC cord-005453-4057qib7 231 64 haploidentical haploidentical JJ cord-005453-4057qib7 231 65 donor donor NN cord-005453-4057qib7 231 66 ( ( -LRB- cord-005453-4057qib7 231 67 11 11 CD cord-005453-4057qib7 231 68 % % NN cord-005453-4057qib7 231 69 ) ) -RRB- cord-005453-4057qib7 231 70 at at IN cord-005453-4057qib7 231 71 EBMT EBMT NNP cord-005453-4057qib7 231 72 participating participate VBG cord-005453-4057qib7 231 73 centers center NNS cord-005453-4057qib7 231 74 . . . cord-005453-4057qib7 232 1 Almost almost RB cord-005453-4057qib7 232 2 half half NN cord-005453-4057qib7 232 3 ( ( -LRB- cord-005453-4057qib7 232 4 49 49 CD cord-005453-4057qib7 232 5 % % NN cord-005453-4057qib7 232 6 ) ) -RRB- cord-005453-4057qib7 232 7 of of IN cord-005453-4057qib7 232 8 the the DT cord-005453-4057qib7 232 9 patients patient NNS cord-005453-4057qib7 232 10 had have VBD cord-005453-4057qib7 232 11 T T NNP cord-005453-4057qib7 232 12 - - HYPH cord-005453-4057qib7 232 13 ALL all DT cord-005453-4057qib7 232 14 and and CC cord-005453-4057qib7 232 15 23 23 CD cord-005453-4057qib7 232 16 % % NN cord-005453-4057qib7 232 17 had have VBD cord-005453-4057qib7 232 18 a a DT cord-005453-4057qib7 232 19 positive positive JJ cord-005453-4057qib7 232 20 Philadelphia Philadelphia NNP cord-005453-4057qib7 232 21 chromosome chromosome NN cord-005453-4057qib7 232 22 . . . cord-005453-4057qib7 233 1 Six six CD cord-005453-4057qib7 233 2 patients patient NNS cord-005453-4057qib7 233 3 ( ( -LRB- cord-005453-4057qib7 233 4 5 5 CD cord-005453-4057qib7 233 5 % % NN cord-005453-4057qib7 233 6 ) ) -RRB- cord-005453-4057qib7 233 7 underwent undergo VBD cord-005453-4057qib7 233 8 a a DT cord-005453-4057qib7 233 9 previous previous JJ cord-005453-4057qib7 233 10 autotransplant autotransplant NN cord-005453-4057qib7 233 11 . . . cord-005453-4057qib7 234 1 Karnofsky Karnofsky NNP cord-005453-4057qib7 234 2 score score NN cord-005453-4057qib7 234 3 was be VBD cord-005453-4057qib7 234 4 above above IN cord-005453-4057qib7 234 5 90 90 CD cord-005453-4057qib7 234 6 in in IN cord-005453-4057qib7 234 7 52 52 CD cord-005453-4057qib7 234 8 % % NN cord-005453-4057qib7 234 9 of of IN cord-005453-4057qib7 234 10 patients patient NNS cord-005453-4057qib7 234 11 . . . cord-005453-4057qib7 235 1 Conditioning conditioning NN cord-005453-4057qib7 235 2 was be VBD cord-005453-4057qib7 235 3 myeloablative myeloablative JJ cord-005453-4057qib7 235 4 ( ( -LRB- cord-005453-4057qib7 235 5 MAC MAC NNP cord-005453-4057qib7 235 6 ) ) -RRB- cord-005453-4057qib7 235 7 with with IN cord-005453-4057qib7 235 8 high high JJ cord-005453-4057qib7 235 9 dose dose NN cord-005453-4057qib7 235 10 TBI TBI NNP cord-005453-4057qib7 235 11 in in IN cord-005453-4057qib7 235 12 30 30 CD cord-005453-4057qib7 235 13 % % NN cord-005453-4057qib7 235 14 of of IN cord-005453-4057qib7 235 15 patients patient NNS cord-005453-4057qib7 235 16 , , , cord-005453-4057qib7 235 17 reduced reduce VBN cord-005453-4057qib7 235 18 intensity intensity NN cord-005453-4057qib7 235 19 ( ( -LRB- cord-005453-4057qib7 235 20 RIC RIC NNP cord-005453-4057qib7 235 21 ) ) -RRB- cord-005453-4057qib7 235 22 including include VBG cord-005453-4057qib7 235 23 low low JJ cord-005453-4057qib7 235 24 dose dose NN cord-005453-4057qib7 235 25 TBI TBI NNP cord-005453-4057qib7 235 26 in in IN cord-005453-4057qib7 235 27 22 22 CD cord-005453-4057qib7 235 28 % % NN cord-005453-4057qib7 235 29 , , , cord-005453-4057qib7 235 30 or or CC cord-005453-4057qib7 235 31 with with IN cord-005453-4057qib7 235 32 chemotherapy chemotherapy NN cord-005453-4057qib7 235 33 alone alone JJ cord-005453-4057qib7 235 34 in in IN cord-005453-4057qib7 235 35 48 48 CD cord-005453-4057qib7 235 36 % % NN cord-005453-4057qib7 235 37 . . . cord-005453-4057qib7 236 1 In in IN cord-005453-4057qib7 236 2 vivo vivo FW cord-005453-4057qib7 236 3 T t NN cord-005453-4057qib7 236 4 cell cell NN cord-005453-4057qib7 236 5 depletion depletion NN cord-005453-4057qib7 236 6 was be VBD cord-005453-4057qib7 236 7 performed perform VBN cord-005453-4057qib7 236 8 in in IN cord-005453-4057qib7 236 9 77 77 CD cord-005453-4057qib7 236 10 cases case NNS cord-005453-4057qib7 236 11 ( ( -LRB- cord-005453-4057qib7 236 12 69 69 CD cord-005453-4057qib7 236 13 % % NN cord-005453-4057qib7 236 14 ) ) -RRB- cord-005453-4057qib7 236 15 . . . cord-005453-4057qib7 237 1 Most Most JJS cord-005453-4057qib7 237 2 patients patient NNS cord-005453-4057qib7 237 3 ( ( -LRB- cord-005453-4057qib7 237 4 74 74 CD cord-005453-4057qib7 237 5 % % NN cord-005453-4057qib7 237 6 ) ) -RRB- cord-005453-4057qib7 237 7 and and CC cord-005453-4057qib7 237 8 about about IN cord-005453-4057qib7 237 9 half half NN cord-005453-4057qib7 237 10 of of IN cord-005453-4057qib7 237 11 the the DT cord-005453-4057qib7 237 12 donors donor NNS cord-005453-4057qib7 237 13 ( ( -LRB- cord-005453-4057qib7 237 14 47 47 CD cord-005453-4057qib7 237 15 % % NN cord-005453-4057qib7 237 16 ) ) -RRB- cord-005453-4057qib7 237 17 were be VBD cord-005453-4057qib7 237 18 CMV CMV NNP cord-005453-4057qib7 237 19 positive positive JJ cord-005453-4057qib7 237 20 . . . cord-005453-4057qib7 238 1 14 14 CD cord-005453-4057qib7 238 2 % % NN cord-005453-4057qib7 238 3 of of IN cord-005453-4057qib7 238 4 patients patient NNS cord-005453-4057qib7 238 5 were be VBD cord-005453-4057qib7 238 6 males male NNS cord-005453-4057qib7 238 7 who who WP cord-005453-4057qib7 238 8 received receive VBD cord-005453-4057qib7 238 9 a a DT cord-005453-4057qib7 238 10 graft graft NN cord-005453-4057qib7 238 11 from from IN cord-005453-4057qib7 238 12 a a DT cord-005453-4057qib7 238 13 female female JJ cord-005453-4057qib7 238 14 donor donor NN cord-005453-4057qib7 238 15 . . . cord-005453-4057qib7 239 1 The the DT cord-005453-4057qib7 239 2 median median JJ cord-005453-4057qib7 239 3 follow follow NN cord-005453-4057qib7 239 4 - - HYPH cord-005453-4057qib7 239 5 up up NN cord-005453-4057qib7 239 6 was be VBD cord-005453-4057qib7 239 7 37 37 CD cord-005453-4057qib7 240 1 ( ( -LRB- cord-005453-4057qib7 240 2 range range NN cord-005453-4057qib7 240 3 , , , cord-005453-4057qib7 240 4 13 13 CD cord-005453-4057qib7 240 5 - - SYM cord-005453-4057qib7 240 6 111 111 CD cord-005453-4057qib7 240 7 ) ) -RRB- cord-005453-4057qib7 240 8 months month NNS cord-005453-4057qib7 240 9 . . . cord-005453-4057qib7 241 1 Results result NNS cord-005453-4057qib7 241 2 : : : cord-005453-4057qib7 242 1 Overall overall RB cord-005453-4057qib7 242 2 , , , cord-005453-4057qib7 242 3 14 14 CD cord-005453-4057qib7 242 4 patients patient NNS cord-005453-4057qib7 242 5 ( ( -LRB- cord-005453-4057qib7 242 6 13 13 CD cord-005453-4057qib7 242 7 % % NN cord-005453-4057qib7 242 8 ) ) -RRB- cord-005453-4057qib7 242 9 failed fail VBD cord-005453-4057qib7 242 10 to to TO cord-005453-4057qib7 242 11 engraft engraft VB cord-005453-4057qib7 242 12 , , , cord-005453-4057qib7 242 13 18 18 CD cord-005453-4057qib7 242 14 ( ( -LRB- cord-005453-4057qib7 242 15 16 16 CD cord-005453-4057qib7 242 16 % % NN cord-005453-4057qib7 242 17 ) ) -RRB- cord-005453-4057qib7 242 18 died die VBD cord-005453-4057qib7 242 19 within within IN cord-005453-4057qib7 242 20 100 100 CD cord-005453-4057qib7 242 21 days day NNS cord-005453-4057qib7 242 22 after after IN cord-005453-4057qib7 242 23 allo allo NN cord-005453-4057qib7 242 24 - - HYPH cord-005453-4057qib7 242 25 SCT SCT NNP cord-005453-4057qib7 242 26 without without IN cord-005453-4057qib7 242 27 relapse relapse NN cord-005453-4057qib7 242 28 , , , cord-005453-4057qib7 242 29 and and CC cord-005453-4057qib7 242 30 64 64 CD cord-005453-4057qib7 242 31 ( ( -LRB- cord-005453-4057qib7 242 32 56 56 CD cord-005453-4057qib7 242 33 % % NN cord-005453-4057qib7 242 34 ) ) -RRB- cord-005453-4057qib7 242 35 could could MD cord-005453-4057qib7 242 36 achieve achieve VB cord-005453-4057qib7 242 37 complete complete JJ cord-005453-4057qib7 242 38 remission remission NN cord-005453-4057qib7 242 39 . . . cord-005453-4057qib7 243 1 At at IN cord-005453-4057qib7 243 2 day day NN cord-005453-4057qib7 243 3 100 100 CD cord-005453-4057qib7 243 4 , , , cord-005453-4057qib7 243 5 the the DT cord-005453-4057qib7 243 6 cumulative cumulative JJ cord-005453-4057qib7 243 7 incidences incidence NNS cord-005453-4057qib7 243 8 of of IN cord-005453-4057qib7 243 9 grade grade NN cord-005453-4057qib7 243 10 II II NNP cord-005453-4057qib7 243 11 - - HYPH cord-005453-4057qib7 243 12 IV IV NNP cord-005453-4057qib7 243 13 and and CC cord-005453-4057qib7 243 14 grade grade NN cord-005453-4057qib7 243 15 III III NNP cord-005453-4057qib7 243 16 - - HYPH cord-005453-4057qib7 243 17 IV IV NNP cord-005453-4057qib7 243 18 acute acute JJ cord-005453-4057qib7 243 19 GVHD GVHD NNP cord-005453-4057qib7 243 20 were be VBD cord-005453-4057qib7 243 21 30 30 CD cord-005453-4057qib7 243 22 % % NN cord-005453-4057qib7 243 23 and and CC cord-005453-4057qib7 243 24 17 17 CD cord-005453-4057qib7 243 25 % % NN cord-005453-4057qib7 243 26 , , , cord-005453-4057qib7 243 27 respectively respectively RB cord-005453-4057qib7 243 28 . . . cord-005453-4057qib7 244 1 The the DT cord-005453-4057qib7 244 2 2year 2year JJ cord-005453-4057qib7 244 3 cumulative cumulative JJ cord-005453-4057qib7 244 4 incidences incidence NNS cord-005453-4057qib7 244 5 of of IN cord-005453-4057qib7 244 6 chronic chronic JJ cord-005453-4057qib7 244 7 and and CC cord-005453-4057qib7 244 8 extensive extensive JJ cord-005453-4057qib7 244 9 chronic chronic JJ cord-005453-4057qib7 244 10 GVHD GVHD NNP cord-005453-4057qib7 244 11 were be VBD cord-005453-4057qib7 244 12 25 25 CD cord-005453-4057qib7 244 13 % % NN cord-005453-4057qib7 244 14 and and CC cord-005453-4057qib7 244 15 11 11 CD cord-005453-4057qib7 244 16 % % NN cord-005453-4057qib7 244 17 , , , cord-005453-4057qib7 244 18 respectively respectively RB cord-005453-4057qib7 244 19 . . . cord-005453-4057qib7 245 1 The the DT cord-005453-4057qib7 245 2 2-year 2-year CD cord-005453-4057qib7 245 3 relapse relapse NN cord-005453-4057qib7 245 4 incidence incidence NN cord-005453-4057qib7 245 5 ( ( -LRB- cord-005453-4057qib7 245 6 RI RI NNP cord-005453-4057qib7 245 7 ) ) -RRB- cord-005453-4057qib7 245 8 and and CC cord-005453-4057qib7 245 9 non non JJ cord-005453-4057qib7 245 10 - - JJ cord-005453-4057qib7 245 11 relapse relapse JJ cord-005453-4057qib7 245 12 mortality mortality NN cord-005453-4057qib7 245 13 ( ( -LRB- cord-005453-4057qib7 245 14 NRM NRM NNP cord-005453-4057qib7 245 15 ) ) -RRB- cord-005453-4057qib7 245 16 were be VBD cord-005453-4057qib7 245 17 45 45 CD cord-005453-4057qib7 245 18 % % NN cord-005453-4057qib7 245 19 and and CC cord-005453-4057qib7 245 20 41 41 CD cord-005453-4057qib7 245 21 % % NN cord-005453-4057qib7 245 22 , , , cord-005453-4057qib7 245 23 respectively respectively RB cord-005453-4057qib7 245 24 . . . cord-005453-4057qib7 246 1 The the DT cord-005453-4057qib7 246 2 2-year 2-year CD cord-005453-4057qib7 246 3 leukemia leukemia NN cord-005453-4057qib7 246 4 free free JJ cord-005453-4057qib7 246 5 survival survival NN cord-005453-4057qib7 246 6 ( ( -LRB- cord-005453-4057qib7 246 7 LFS LFS NNP cord-005453-4057qib7 246 8 ) ) -RRB- cord-005453-4057qib7 246 9 , , , cord-005453-4057qib7 246 10 overall overall JJ cord-005453-4057qib7 246 11 survival survival NN cord-005453-4057qib7 246 12 ( ( -LRB- cord-005453-4057qib7 246 13 OS OS NNP cord-005453-4057qib7 246 14 ) ) -RRB- cord-005453-4057qib7 246 15 and and CC cord-005453-4057qib7 246 16 GVHD GVHD NNP cord-005453-4057qib7 246 17 relapsefree relapsefree JJ cord-005453-4057qib7 246 18 survival survival NN cord-005453-4057qib7 246 19 ( ( -LRB- cord-005453-4057qib7 246 20 GRFS GRFS NNP cord-005453-4057qib7 246 21 ) ) -RRB- cord-005453-4057qib7 246 22 were be VBD cord-005453-4057qib7 246 23 14 14 CD cord-005453-4057qib7 246 24 % % NN cord-005453-4057qib7 246 25 , , , cord-005453-4057qib7 246 26 17 17 CD cord-005453-4057qib7 246 27 % % NN cord-005453-4057qib7 246 28 and and CC cord-005453-4057qib7 246 29 12 12 CD cord-005453-4057qib7 246 30 % % NN cord-005453-4057qib7 246 31 , , , cord-005453-4057qib7 246 32 respectively respectively RB cord-005453-4057qib7 246 33 . . . cord-005453-4057qib7 247 1 In in IN cord-005453-4057qib7 247 2 a a DT cord-005453-4057qib7 247 3 multivariable multivariable JJ cord-005453-4057qib7 247 4 Cox Cox NNP cord-005453-4057qib7 247 5 analysis analysis NN cord-005453-4057qib7 247 6 , , , cord-005453-4057qib7 247 7 Karnofosky Karnofosky NNP cord-005453-4057qib7 247 8 score score VBP cord-005453-4057qib7 247 9 below below IN cord-005453-4057qib7 247 10 90 90 CD cord-005453-4057qib7 247 11 negatively negatively RB cord-005453-4057qib7 247 12 affected affect VBN cord-005453-4057qib7 247 13 RI RI NNP cord-005453-4057qib7 247 14 , , , cord-005453-4057qib7 247 15 LFS lfs NN cord-005453-4057qib7 247 16 , , , cord-005453-4057qib7 247 17 OS OS NNP cord-005453-4057qib7 247 18 and and CC cord-005453-4057qib7 247 19 GRFS GRFS NNP cord-005453-4057qib7 247 20 . . . cord-005453-4057qib7 248 1 Also also RB cord-005453-4057qib7 248 2 , , , cord-005453-4057qib7 248 3 conditioning condition VBG cord-005453-4057qib7 248 4 with with IN cord-005453-4057qib7 248 5 chemotherapy chemotherapy NN cord-005453-4057qib7 248 6 alone alone RB cord-005453-4057qib7 248 7 , , , cord-005453-4057qib7 248 8 compared compare VBN cord-005453-4057qib7 248 9 to to IN cord-005453-4057qib7 248 10 TBIbased tbibase VBN cord-005453-4057qib7 248 11 conditioning conditioning NN cord-005453-4057qib7 248 12 , , , cord-005453-4057qib7 248 13 negatively negatively RB cord-005453-4057qib7 248 14 affected affect VBN cord-005453-4057qib7 248 15 relapse relapse NN cord-005453-4057qib7 248 16 rates rate NNS cord-005453-4057qib7 248 17 ( ( -LRB- cord-005453-4057qib7 248 18 HR=4.13 HR=4.13 NNP cord-005453-4057qib7 248 19 ; ; : cord-005453-4057qib7 248 20 p=0.0006 p=0.0006 ADD cord-005453-4057qib7 248 21 ) ) -RRB- cord-005453-4057qib7 248 22 , , , cord-005453-4057qib7 248 23 LFS LFS NNP cord-005453-4057qib7 248 24 ( ( -LRB- cord-005453-4057qib7 248 25 HR=2.32 hr=2.32 XX cord-005453-4057qib7 248 26 ; ; : cord-005453-4057qib7 248 27 p=0.004 p=0.004 NNP cord-005453-4057qib7 248 28 ) ) -RRB- cord-005453-4057qib7 248 29 and and CC cord-005453-4057qib7 248 30 OS OS NNP cord-005453-4057qib7 248 31 ( ( -LRB- cord-005453-4057qib7 248 32 HR=2.29 hr=2.29 UH cord-005453-4057qib7 248 33 ; ; : cord-005453-4057qib7 248 34 p=0.006 p=0.006 NNS cord-005453-4057qib7 248 35 ) ) -RRB- cord-005453-4057qib7 248 36 . . . cord-005453-4057qib7 249 1 Conclusions conclusion NNS cord-005453-4057qib7 249 2 : : : cord-005453-4057qib7 250 1 Allo Allo NNP cord-005453-4057qib7 250 2 - - HYPH cord-005453-4057qib7 250 3 SCT SCT NNP cord-005453-4057qib7 250 4 using use VBG cord-005453-4057qib7 250 5 a a DT cord-005453-4057qib7 250 6 sequential sequential JJ cord-005453-4057qib7 250 7 conditioning conditioning NN cord-005453-4057qib7 250 8 regimen regimen NN cord-005453-4057qib7 250 9 is be VBZ cord-005453-4057qib7 250 10 proposed propose VBN cord-005453-4057qib7 250 11 by by IN cord-005453-4057qib7 250 12 different different JJ cord-005453-4057qib7 250 13 teams team NNS cord-005453-4057qib7 250 14 in in IN cord-005453-4057qib7 250 15 RR rr NN cord-005453-4057qib7 250 16 - - HYPH cord-005453-4057qib7 250 17 ALL ALL NNP cord-005453-4057qib7 250 18 , , , cord-005453-4057qib7 250 19 and and CC cord-005453-4057qib7 250 20 could could MD cord-005453-4057qib7 250 21 be be VB cord-005453-4057qib7 250 22 an an DT cord-005453-4057qib7 250 23 option option NN cord-005453-4057qib7 250 24 , , , cord-005453-4057qib7 250 25 especially especially RB cord-005453-4057qib7 250 26 when when WRB cord-005453-4057qib7 250 27 considering consider VBG cord-005453-4057qib7 250 28 a a DT cord-005453-4057qib7 250 29 TBIbased tbibase VBN cord-005453-4057qib7 250 30 regimen regimen NN cord-005453-4057qib7 250 31 . . . cord-005453-4057qib7 251 1 However however RB cord-005453-4057qib7 251 2 , , , cord-005453-4057qib7 251 3 the the DT cord-005453-4057qib7 251 4 overall overall JJ cord-005453-4057qib7 251 5 2-year 2-year CD cord-005453-4057qib7 251 6 LFS lfs NN cord-005453-4057qib7 251 7 of of IN cord-005453-4057qib7 251 8 14 14 CD cord-005453-4057qib7 251 9 % % NN cord-005453-4057qib7 251 10 suggests suggest VBZ cord-005453-4057qib7 251 11 that that IN cord-005453-4057qib7 251 12 these these DT cord-005453-4057qib7 251 13 patients patient NNS cord-005453-4057qib7 251 14 still still RB cord-005453-4057qib7 251 15 face face VBP cord-005453-4057qib7 251 16 extremely extremely RB cord-005453-4057qib7 251 17 dismal dismal JJ cord-005453-4057qib7 251 18 outcomes outcome NNS cord-005453-4057qib7 251 19 , , , cord-005453-4057qib7 251 20 highlighting highlight VBG cord-005453-4057qib7 251 21 that that IN cord-005453-4057qib7 251 22 other other JJ cord-005453-4057qib7 251 23 therapies therapy NNS cord-005453-4057qib7 251 24 ( ( -LRB- cord-005453-4057qib7 252 1 e.g. e.g. IN cord-005453-4057qib7 252 2 BITE bite NN cord-005453-4057qib7 252 3 antibodies antibody NNS cord-005453-4057qib7 252 4 , , , cord-005453-4057qib7 252 5 inotuzumab inotuzumab NNS cord-005453-4057qib7 252 6 , , , cord-005453-4057qib7 252 7 CAR car NN cord-005453-4057qib7 252 8 T t NN cord-005453-4057qib7 252 9 cells cell NNS cord-005453-4057qib7 252 10 ) ) -RRB- cord-005453-4057qib7 252 11 need need VBP cord-005453-4057qib7 252 12 to to TO cord-005453-4057qib7 252 13 be be VB cord-005453-4057qib7 252 14 combined combine VBN cord-005453-4057qib7 252 15 prior prior RB cord-005453-4057qib7 252 16 and/or and/or CC cord-005453-4057qib7 252 17 after after IN cord-005453-4057qib7 252 18 allo allo NN cord-005453-4057qib7 252 19 - - HYPH cord-005453-4057qib7 252 20 SCT SCT NNP cord-005453-4057qib7 252 21 in in IN cord-005453-4057qib7 252 22 order order NN cord-005453-4057qib7 252 23 to to TO cord-005453-4057qib7 252 24 further further RB cord-005453-4057qib7 252 25 improve improve VB cord-005453-4057qib7 252 26 outcome outcome NN cord-005453-4057qib7 252 27 . . . cord-005453-4057qib7 253 1 Disclosure disclosure NN cord-005453-4057qib7 253 2 : : : cord-005453-4057qib7 253 3 no no DT cord-005453-4057qib7 253 4 conflict conflict NN cord-005453-4057qib7 253 5 of of IN cord-005453-4057qib7 253 6 interest interest NN cord-005453-4057qib7 253 7 , , , cord-005453-4057qib7 253 8 no no DT cord-005453-4057qib7 253 9 funding funding NN cord-005453-4057qib7 253 10 received receive VBD cord-005453-4057qib7 253 11 chemotherapy chemotherapy NN cord-005453-4057qib7 253 12 courses course NNS cord-005453-4057qib7 253 13 , , , cord-005453-4057qib7 253 14 only only RB cord-005453-4057qib7 253 15 2 2 CD cord-005453-4057qib7 253 16 pts pt NNS cord-005453-4057qib7 253 17 were be VBD cord-005453-4057qib7 253 18 not not RB cord-005453-4057qib7 253 19 treated treat VBN cord-005453-4057qib7 253 20 : : : cord-005453-4057qib7 253 21 1 1 CD cord-005453-4057qib7 253 22 pts pt NNS cord-005453-4057qib7 253 23 for for IN cord-005453-4057qib7 253 24 the the DT cord-005453-4057qib7 253 25 worsening worsening NN cord-005453-4057qib7 253 26 of of IN cord-005453-4057qib7 253 27 the the DT cord-005453-4057qib7 253 28 general general JJ cord-005453-4057qib7 253 29 status status NN cord-005453-4057qib7 253 30 and and CC cord-005453-4057qib7 253 31 the the DT cord-005453-4057qib7 253 32 other other JJ cord-005453-4057qib7 253 33 for for IN cord-005453-4057qib7 253 34 invasive invasive JJ cord-005453-4057qib7 253 35 fungal fungal JJ cord-005453-4057qib7 253 36 infection infection NN cord-005453-4057qib7 253 37 . . . cord-005453-4057qib7 254 1 Results result NNS cord-005453-4057qib7 254 2 : : : cord-005453-4057qib7 254 3 Forty forty CD cord-005453-4057qib7 254 4 - - HYPH cord-005453-4057qib7 254 5 three three CD cord-005453-4057qib7 254 6 pts pt NNS cord-005453-4057qib7 254 7 ( ( -LRB- cord-005453-4057qib7 254 8 42 42 CD cord-005453-4057qib7 254 9 % % NN cord-005453-4057qib7 254 10 ) ) -RRB- cord-005453-4057qib7 254 11 were be VBD cord-005453-4057qib7 254 12 in in IN cord-005453-4057qib7 254 13 complete complete JJ cord-005453-4057qib7 254 14 remission remission NN cord-005453-4057qib7 254 15 ( ( -LRB- cord-005453-4057qib7 254 16 CR CR NNP cord-005453-4057qib7 254 17 ) ) -RRB- cord-005453-4057qib7 254 18 and and CC cord-005453-4057qib7 254 19 negative negative JJ cord-005453-4057qib7 254 20 minimal minimal JJ cord-005453-4057qib7 254 21 residual residual JJ cord-005453-4057qib7 254 22 disease disease NN cord-005453-4057qib7 254 23 ( ( -LRB- cord-005453-4057qib7 254 24 MRD MRD NNP cord-005453-4057qib7 254 25 ) ) -RRB- cord-005453-4057qib7 254 26 at at IN cord-005453-4057qib7 254 27 the the DT cord-005453-4057qib7 254 28 time time NN cord-005453-4057qib7 254 29 of of IN cord-005453-4057qib7 254 30 HSCT HSCT NNP cord-005453-4057qib7 254 31 ; ; : cord-005453-4057qib7 254 32 16 16 CD cord-005453-4057qib7 254 33 pts pt NNS cord-005453-4057qib7 254 34 were be VBD cord-005453-4057qib7 254 35 in in IN cord-005453-4057qib7 254 36 active active JJ cord-005453-4057qib7 254 37 disease disease NN cord-005453-4057qib7 254 38 ( ( -LRB- cord-005453-4057qib7 254 39 16 16 CD cord-005453-4057qib7 254 40 % % NN cord-005453-4057qib7 254 41 ) ) -RRB- cord-005453-4057qib7 254 42 , , , cord-005453-4057qib7 254 43 and and CC cord-005453-4057qib7 254 44 44 44 CD cord-005453-4057qib7 254 45 ( ( -LRB- cord-005453-4057qib7 254 46 42 42 CD cord-005453-4057qib7 254 47 % % NN cord-005453-4057qib7 254 48 ) ) -RRB- cord-005453-4057qib7 254 49 showed show VBD cord-005453-4057qib7 254 50 a a DT cord-005453-4057qib7 254 51 morphological morphological JJ cord-005453-4057qib7 254 52 CR cr NN cord-005453-4057qib7 254 53 with with IN cord-005453-4057qib7 254 54 positive positive JJ cord-005453-4057qib7 254 55 MRD MRD NNP cord-005453-4057qib7 254 56 . . . cord-005453-4057qib7 254 57 41pts 41pts CD cord-005453-4057qib7 254 58 ( ( -LRB- cord-005453-4057qib7 254 59 40 40 CD cord-005453-4057qib7 254 60 % % NN cord-005453-4057qib7 254 61 ) ) -RRB- cord-005453-4057qib7 254 62 developed develop VBN cord-005453-4057qib7 254 63 chronic chronic NN cord-005453-4057qib7 254 64 Graft graft NN cord-005453-4057qib7 254 65 Versus Versus NNP cord-005453-4057qib7 254 66 - - HYPH cord-005453-4057qib7 254 67 Host Host NNP cord-005453-4057qib7 254 68 Disease Disease NNP cord-005453-4057qib7 254 69 ( ( -LRB- cord-005453-4057qib7 254 70 cGVHD cGVHD NNP cord-005453-4057qib7 254 71 ) ) -RRB- cord-005453-4057qib7 254 72 as as IN cord-005453-4057qib7 254 73 followed follow VBN cord-005453-4057qib7 254 74 : : : cord-005453-4057qib7 255 1 23pts 23pts NNP cord-005453-4057qib7 255 2 ( ( -LRB- cord-005453-4057qib7 255 3 22 22 CD cord-005453-4057qib7 255 4 % % NN cord-005453-4057qib7 255 5 ) ) -RRB- cord-005453-4057qib7 255 6 mild mild JJ cord-005453-4057qib7 255 7 , , , cord-005453-4057qib7 255 8 17pts 17pts JJ cord-005453-4057qib7 255 9 ( ( -LRB- cord-005453-4057qib7 255 10 16 16 CD cord-005453-4057qib7 255 11 % % NN cord-005453-4057qib7 255 12 ) ) -RRB- cord-005453-4057qib7 255 13 moderate moderate JJ cord-005453-4057qib7 255 14 , , , cord-005453-4057qib7 255 15 and and CC cord-005453-4057qib7 255 16 only only RB cord-005453-4057qib7 255 17 1 1 CD cord-005453-4057qib7 255 18 sever sever NN cord-005453-4057qib7 255 19 grade grade NN cord-005453-4057qib7 255 20 respectfully respectfully RB cord-005453-4057qib7 255 21 . . . cord-005453-4057qib7 256 1 Only only RB cord-005453-4057qib7 256 2 1 1 CD cord-005453-4057qib7 256 3 patient patient NN cord-005453-4057qib7 256 4 developed develop VBD cord-005453-4057qib7 256 5 cGVHD cgvhd NN cord-005453-4057qib7 256 6 after after IN cord-005453-4057qib7 256 7 DLI DLI NNP cord-005453-4057qib7 256 8 . . . cord-005453-4057qib7 257 1 The the DT cord-005453-4057qib7 257 2 overall overall JJ cord-005453-4057qib7 257 3 Leukemia Leukemia NNP cord-005453-4057qib7 257 4 Free Free NNP cord-005453-4057qib7 257 5 Survival Survival NNP cord-005453-4057qib7 257 6 ( ( -LRB- cord-005453-4057qib7 257 7 LFS LFS NNP cord-005453-4057qib7 257 8 ) ) -RRB- cord-005453-4057qib7 257 9 time time NN cord-005453-4057qib7 257 10 was be VBD cord-005453-4057qib7 257 11 16 16 CD cord-005453-4057qib7 257 12 months month NNS cord-005453-4057qib7 257 13 , , , cord-005453-4057qib7 257 14 the the DT cord-005453-4057qib7 257 15 absence absence NN cord-005453-4057qib7 257 16 of of IN cord-005453-4057qib7 257 17 cGVHD cGVHD NNP cord-005453-4057qib7 258 1 ( ( -LRB- cord-005453-4057qib7 258 2 Hazard Hazard NNP cord-005453-4057qib7 258 3 Ratio Ratio NNP cord-005453-4057qib7 258 4 -HR -hr NN cord-005453-4057qib7 258 5 : : : cord-005453-4057qib7 258 6 5,968 5,968 CD cord-005453-4057qib7 258 7 ; ; : cord-005453-4057qib7 258 8 p p NN cord-005453-4057qib7 258 9 = = SYM cord-005453-4057qib7 258 10 0,01 0,01 NN cord-005453-4057qib7 258 11 ) ) -RRB- cord-005453-4057qib7 259 1 and and CC cord-005453-4057qib7 259 2 the the DT cord-005453-4057qib7 259 3 pre pre JJ cord-005453-4057qib7 259 4 - - JJ cord-005453-4057qib7 259 5 HSCT hsct JJ cord-005453-4057qib7 259 6 disease disease NN cord-005453-4057qib7 259 7 status status NN cord-005453-4057qib7 259 8 ( ( -LRB- cord-005453-4057qib7 259 9 HR HR NNP cord-005453-4057qib7 259 10 2,353 2,353 CD cord-005453-4057qib7 259 11 ; ; : cord-005453-4057qib7 259 12 p p NN cord-005453-4057qib7 259 13 = = SYM cord-005453-4057qib7 259 14 0,028 0,028 CD cord-005453-4057qib7 259 15 ) ) -RRB- cord-005453-4057qib7 259 16 were be VBD cord-005453-4057qib7 259 17 the the DT cord-005453-4057qib7 259 18 most most RBS cord-005453-4057qib7 259 19 important important JJ cord-005453-4057qib7 259 20 factors factor NNS cord-005453-4057qib7 259 21 on on IN cord-005453-4057qib7 259 22 LFS LFS NNP cord-005453-4057qib7 259 23 . . . cord-005453-4057qib7 260 1 All all DT cord-005453-4057qib7 260 2 pts pt NNS cord-005453-4057qib7 260 3 treated treat VBN cord-005453-4057qib7 260 4 with with IN cord-005453-4057qib7 260 5 chemo chemo NN cord-005453-4057qib7 260 6 - - HYPH cord-005453-4057qib7 260 7 based base VBN cord-005453-4057qib7 260 8 regimens regimen NNS cord-005453-4057qib7 260 9 died die VBD cord-005453-4057qib7 260 10 due due JJ cord-005453-4057qib7 260 11 to to IN cord-005453-4057qib7 260 12 progression progression NN cord-005453-4057qib7 260 13 or or CC cord-005453-4057qib7 260 14 infective infective JJ cord-005453-4057qib7 260 15 complications complication NNS cord-005453-4057qib7 260 16 . . . cord-005453-4057qib7 261 1 1 1 CD cord-005453-4057qib7 261 2 patient patient NN cord-005453-4057qib7 261 3 of of IN cord-005453-4057qib7 261 4 Aza Aza NNP cord-005453-4057qib7 261 5 / / SYM cord-005453-4057qib7 261 6 DLI DLI NNP cord-005453-4057qib7 261 7 group group NN cord-005453-4057qib7 261 8 is be VBZ cord-005453-4057qib7 261 9 still still RB cord-005453-4057qib7 261 10 alive alive JJ cord-005453-4057qib7 261 11 with with IN cord-005453-4057qib7 261 12 a a DT cord-005453-4057qib7 261 13 extramedullary extramedullary JJ cord-005453-4057qib7 261 14 relapse relapse NN cord-005453-4057qib7 261 15 ; ; : cord-005453-4057qib7 261 16 2 2 CD cord-005453-4057qib7 261 17 pts pt NNS cord-005453-4057qib7 261 18 treated treat VBN cord-005453-4057qib7 261 19 with with IN cord-005453-4057qib7 261 20 Bl Bl NNP cord-005453-4057qib7 261 21 / / SYM cord-005453-4057qib7 261 22 DLI DLI NNP cord-005453-4057qib7 261 23 are be VBP cord-005453-4057qib7 261 24 in in IN cord-005453-4057qib7 261 25 CR CR NNP cord-005453-4057qib7 261 26 . . . cord-005453-4057qib7 262 1 OS OS NNP cord-005453-4057qib7 262 2 was be VBD cord-005453-4057qib7 262 3 better well JJR cord-005453-4057qib7 262 4 for for IN cord-005453-4057qib7 262 5 the the DT cord-005453-4057qib7 262 6 DLI DLI NNP cord-005453-4057qib7 262 7 group group NN cord-005453-4057qib7 262 8 compared compare VBN cord-005453-4057qib7 262 9 to to IN cord-005453-4057qib7 262 10 the the DT cord-005453-4057qib7 262 11 chemotherapy chemotherapy NN cord-005453-4057qib7 262 12 group group NN cord-005453-4057qib7 262 13 ( ( -LRB- cord-005453-4057qib7 262 14 28 28 CD cord-005453-4057qib7 262 15 vs vs IN cord-005453-4057qib7 262 16 2 2 CD cord-005453-4057qib7 262 17 months month NNS cord-005453-4057qib7 262 18 respectfully respectfully RB cord-005453-4057qib7 262 19 ; ; : cord-005453-4057qib7 262 20 p p XX cord-005453-4057qib7 262 21 < < XX cord-005453-4057qib7 262 22 0,001 0,001 CD cord-005453-4057qib7 262 23 ) ) -RRB- cord-005453-4057qib7 262 24 . . . cord-005453-4057qib7 263 1 Conclusions conclusion NNS cord-005453-4057qib7 263 2 : : : cord-005453-4057qib7 264 1 DLI DLI NNP cord-005453-4057qib7 264 2 after after IN cord-005453-4057qib7 264 3 allo allo NN cord-005453-4057qib7 264 4 - - HYPH cord-005453-4057qib7 264 5 HSCT HSCT NNP cord-005453-4057qib7 264 6 has have VBZ cord-005453-4057qib7 264 7 exhibited exhibit VBN cord-005453-4057qib7 264 8 definite definite JJ cord-005453-4057qib7 264 9 anti anti JJ cord-005453-4057qib7 264 10 - - JJ cord-005453-4057qib7 264 11 leukemic leukemic JJ cord-005453-4057qib7 264 12 effects effect NNS cord-005453-4057qib7 264 13 in in IN cord-005453-4057qib7 264 14 post post JJ cord-005453-4057qib7 264 15 - - JJ cord-005453-4057qib7 264 16 transplant transplant JJ cord-005453-4057qib7 264 17 patients patient NNS cord-005453-4057qib7 264 18 . . . cord-005453-4057qib7 265 1 Bl Bl NNP cord-005453-4057qib7 265 2 and and CC cord-005453-4057qib7 265 3 Aza Aza NNP cord-005453-4057qib7 265 4 were be VBD cord-005453-4057qib7 265 5 reported report VBN cord-005453-4057qib7 265 6 to to TO cord-005453-4057qib7 265 7 increase increase VB cord-005453-4057qib7 265 8 DLI DLI NNP cord-005453-4057qib7 265 9 's 's POS cord-005453-4057qib7 265 10 Graft Graft NNP cord-005453-4057qib7 265 11 vs vs IN cord-005453-4057qib7 265 12 - - HYPH cord-005453-4057qib7 265 13 Leukemia leukemia NN cord-005453-4057qib7 265 14 ( ( -LRB- cord-005453-4057qib7 265 15 GVL GVL NNP cord-005453-4057qib7 265 16 ) ) -RRB- cord-005453-4057qib7 265 17 effect effect NN cord-005453-4057qib7 265 18 . . . cord-005453-4057qib7 266 1 Although although IN cord-005453-4057qib7 266 2 cGVHD cGVHD NNP cord-005453-4057qib7 266 3 could could MD cord-005453-4057qib7 266 4 be be VB cord-005453-4057qib7 266 5 the the DT cord-005453-4057qib7 266 6 most most RBS cord-005453-4057qib7 266 7 important important JJ cord-005453-4057qib7 266 8 protective protective JJ cord-005453-4057qib7 266 9 factor factor NN cord-005453-4057qib7 266 10 against against IN cord-005453-4057qib7 266 11 the the DT cord-005453-4057qib7 266 12 relapse relapse NN cord-005453-4057qib7 266 13 but but CC cord-005453-4057qib7 266 14 it -PRON- PRP cord-005453-4057qib7 266 15 remains remain VBZ cord-005453-4057qib7 266 16 the the DT cord-005453-4057qib7 266 17 main main JJ cord-005453-4057qib7 266 18 cause cause NN cord-005453-4057qib7 266 19 of of IN cord-005453-4057qib7 266 20 morbidity morbidity NN cord-005453-4057qib7 266 21 . . . cord-005453-4057qib7 267 1 Maximising maximise VBG cord-005453-4057qib7 267 2 the the DT cord-005453-4057qib7 267 3 GVL GVL NNP cord-005453-4057qib7 267 4 effect effect NN cord-005453-4057qib7 267 5 without without IN cord-005453-4057qib7 267 6 putting put VBG cord-005453-4057qib7 267 7 the the DT cord-005453-4057qib7 267 8 patient patient NN cord-005453-4057qib7 267 9 at at IN cord-005453-4057qib7 267 10 risk risk NN cord-005453-4057qib7 267 11 of of IN cord-005453-4057qib7 267 12 GVHD GVHD NNP cord-005453-4057qib7 267 13 still still RB cord-005453-4057qib7 267 14 represents represent VBZ cord-005453-4057qib7 267 15 an an DT cord-005453-4057qib7 267 16 unmet unmet JJ cord-005453-4057qib7 267 17 need need NN cord-005453-4057qib7 267 18 . . . cord-005453-4057qib7 268 1 Our -PRON- PRP$ cord-005453-4057qib7 268 2 data datum NNS cord-005453-4057qib7 268 3 show show VBP cord-005453-4057qib7 268 4 that that IN cord-005453-4057qib7 268 5 the the DT cord-005453-4057qib7 268 6 combination combination NN cord-005453-4057qib7 268 7 of of IN cord-005453-4057qib7 268 8 either either DT cord-005453-4057qib7 268 9 Bl Bl NNP cord-005453-4057qib7 268 10 or or CC cord-005453-4057qib7 268 11 Aza Aza NNP cord-005453-4057qib7 268 12 with with IN cord-005453-4057qib7 268 13 DLI DLI NNP cord-005453-4057qib7 268 14 infusion infusion NN cord-005453-4057qib7 268 15 is be VBZ cord-005453-4057qib7 268 16 safe safe JJ cord-005453-4057qib7 268 17 and and CC cord-005453-4057qib7 268 18 might may MD cord-005453-4057qib7 268 19 represent represent VB cord-005453-4057qib7 268 20 an an DT cord-005453-4057qib7 268 21 improvement improvement NN cord-005453-4057qib7 268 22 in in IN cord-005453-4057qib7 268 23 disease disease NN cord-005453-4057qib7 268 24 control control NN cord-005453-4057qib7 268 25 in in IN cord-005453-4057qib7 268 26 the the DT cord-005453-4057qib7 268 27 early early JJ cord-005453-4057qib7 268 28 phase phase NN cord-005453-4057qib7 268 29 of of IN cord-005453-4057qib7 268 30 relapse relapse NN cord-005453-4057qib7 268 31 . . . cord-005453-4057qib7 269 1 Disclosure disclosure NN cord-005453-4057qib7 269 2 : : : cord-005453-4057qib7 269 3 Nothing nothing NN cord-005453-4057qib7 269 4 to to TO cord-005453-4057qib7 269 5 declare declare VB cord-005453-4057qib7 269 6 P018 p018 CD cord-005453-4057qib7 269 7 Increased increase VBN cord-005453-4057qib7 269 8 detection detection NN cord-005453-4057qib7 269 9 of of IN cord-005453-4057qib7 269 10 ( ( -LRB- cord-005453-4057qib7 269 11 Leukemiaspecific Leukemiaspecific NNP cord-005453-4057qib7 269 12 ) ) -RRB- cord-005453-4057qib7 269 13 adaptive adaptive JJ cord-005453-4057qib7 269 14 and and CC cord-005453-4057qib7 269 15 innate innate JJ cord-005453-4057qib7 269 16 immune immune JJ cord-005453-4057qib7 269 17 - - HYPH cord-005453-4057qib7 269 18 reactive reactive JJ cord-005453-4057qib7 269 19 cells cell NNS cord-005453-4057qib7 269 20 under under IN cord-005453-4057qib7 269 21 treatment treatment NN cord-005453-4057qib7 269 22 of of IN cord-005453-4057qib7 269 23 AMLdiseased amldisease VBN cord-005453-4057qib7 269 24 rats rat NNS cord-005453-4057qib7 269 25 and and CC cord-005453-4057qib7 269 26 one one CD cord-005453-4057qib7 269 27 therapy therapy NN cord-005453-4057qib7 269 28 - - HYPH cord-005453-4057qib7 269 29 refractory refractory JJ cord-005453-4057qib7 269 30 AML aml NN cord-005453-4057qib7 269 31 - - HYPH cord-005453-4057qib7 269 32 patient patient JJ cord-005453-4057qib7 269 33 with with IN cord-005453-4057qib7 269 34 blastmodulating blastmodulating NN cord-005453-4057qib7 269 35 , , , cord-005453-4057qib7 269 36 clinically clinically RB cord-005453-4057qib7 269 37 approved approve VBN cord-005453-4057qib7 269 38 response response NN cord-005453-4057qib7 269 39 modifiers modifier NNS cord-005453-4057qib7 269 40 ( ( -LRB- cord-005453-4057qib7 269 41 PG PG NNP cord-005453-4057qib7 269 42 - - HYPH cord-005453-4057qib7 269 43 E2,Kit E2,Kit NNP cord-005453-4057qib7 269 44 - - HYPH cord-005453-4057qib7 269 45 K K NNP cord-005453-4057qib7 269 46 ) ) -RRB- cord-005453-4057qib7 269 47 or or CC cord-005453-4057qib7 269 48 + + . cord-005453-4057qib7 270 1 PGE1 PGE1 NNP cord-005453-4057qib7 270 2 ( ( -LRB- cord-005453-4057qib7 270 3 Kit kit NN cord-005453-4057qib7 270 4 - - HYPH cord-005453-4057qib7 270 5 M),patent M),patent NNP cord-005453-4057qib7 270 6 102014014993 102014014993 CD cord-005453-4057qib7 270 7 ) ) -RRB- cord-005453-4057qib7 270 8 convert convert VBP cord-005453-4057qib7 270 9 myeloid myeloid NN cord-005453-4057qib7 270 10 blasts blast NNS cord-005453-4057qib7 270 11 into into IN cord-005453-4057qib7 270 12 dendritic dendritic JJ cord-005453-4057qib7 270 13 cells cell NNS cord-005453-4057qib7 270 14 of of IN cord-005453-4057qib7 270 15 leukemic leukemic JJ cord-005453-4057qib7 270 16 origin origin NN cord-005453-4057qib7 270 17 ( ( -LRB- cord-005453-4057qib7 270 18 DC DC NNP cord-005453-4057qib7 270 19 leu leu NNP cord-005453-4057qib7 270 20 ) ) -RRB- cord-005453-4057qib7 270 21 . . . cord-005453-4057qib7 271 1 After after IN cord-005453-4057qib7 271 2 stimulation stimulation NN cord-005453-4057qib7 271 3 with with IN cord-005453-4057qib7 271 4 DC DC NNP cord-005453-4057qib7 271 5 leu leu NNP cord-005453-4057qib7 271 6 , , , cord-005453-4057qib7 271 7 antileukemic antileukemic NNP cord-005453-4057qib7 271 8 Tcells Tcells NNP cord-005453-4057qib7 271 9 can can MD cord-005453-4057qib7 271 10 be be VB cord-005453-4057qib7 271 11 generated generate VBN cord-005453-4057qib7 271 12 ex ex FW cord-005453-4057qib7 271 13 vivo vivo NN cord-005453-4057qib7 271 14 . . . cord-005453-4057qib7 272 1 The the DT cord-005453-4057qib7 272 2 compounds compound NNS cord-005453-4057qib7 272 3 are be VBP cord-005453-4057qib7 272 4 approved approve VBN cord-005453-4057qib7 272 5 for for IN cord-005453-4057qib7 272 6 clinical clinical JJ cord-005453-4057qib7 272 7 use use NN cord-005453-4057qib7 272 8 and and CC cord-005453-4057qib7 272 9 are be VBP cord-005453-4057qib7 272 10 therefore therefore RB cord-005453-4057qib7 272 11 attractive attractive JJ cord-005453-4057qib7 272 12 tools tool NNS cord-005453-4057qib7 272 13 for for IN cord-005453-4057qib7 272 14 immunotherapy immunotherapy NN cord-005453-4057qib7 272 15 in in IN cord-005453-4057qib7 272 16 myeloid myeloid JJ cord-005453-4057qib7 272 17 leukemia leukemia NN cord-005453-4057qib7 272 18 . . . cord-005453-4057qib7 273 1 Methods method NNS cord-005453-4057qib7 273 2 : : : cord-005453-4057qib7 273 3 DC DC NNP cord-005453-4057qib7 273 4 / / SYM cord-005453-4057qib7 273 5 DCleu DCleu NNP cord-005453-4057qib7 273 6 - - HYPH cord-005453-4057qib7 273 7 culture culture NN cord-005453-4057qib7 273 8 from from IN cord-005453-4057qib7 273 9 rats'/patients rats'/patient NNS cord-005453-4057qib7 273 10 ' ' POS cord-005453-4057qib7 273 11 wholeblood wholeblood NN cord-005453-4057qib7 273 12 ( ( -LRB- cord-005453-4057qib7 273 13 WB WB NNP cord-005453-4057qib7 273 14 ) ) -RRB- cord-005453-4057qib7 273 15 with with IN cord-005453-4057qib7 273 16 kits kit NNS cord-005453-4057qib7 273 17 , , , cord-005453-4057qib7 273 18 mixed mixed JJ cord-005453-4057qib7 273 19 lymphocyte lymphocyte NN cord-005453-4057qib7 273 20 culture culture NN cord-005453-4057qib7 273 21 ( ( -LRB- cord-005453-4057qib7 273 22 MLC MLC NNP cord-005453-4057qib7 273 23 ) ) -RRB- cord-005453-4057qib7 273 24 of of IN cord-005453-4057qib7 273 25 Tcells Tcells NNP cord-005453-4057qib7 273 26 with with IN cord-005453-4057qib7 273 27 kit kit NN cord-005453-4057qib7 273 28 - - HYPH cord-005453-4057qib7 273 29 treated treat VBN cord-005453-4057qib7 273 30 blood blood NN cord-005453-4057qib7 273 31 , , , cord-005453-4057qib7 273 32 functional functional JJ cord-005453-4057qib7 273 33 blast blast NN cord-005453-4057qib7 273 34 - - HYPH cord-005453-4057qib7 273 35 cytotoxicity cytotoxicity NN cord-005453-4057qib7 273 36 and and CC cord-005453-4057qib7 273 37 leukemia leukemia NN cord-005453-4057qib7 273 38 - - HYPH cord-005453-4057qib7 273 39 specificity specificity NN cord-005453-4057qib7 273 40 assays assay NNS cord-005453-4057qib7 273 41 ( ( -LRB- cord-005453-4057qib7 273 42 CSA CSA NNP cord-005453-4057qib7 273 43 / / SYM cord-005453-4057qib7 273 44 ELISPOT ELISPOT NNP cord-005453-4057qib7 273 45 / / SYM cord-005453-4057qib7 273 46 Degranulation Degranulation NNP cord-005453-4057qib7 273 47 / / , cord-005453-4057qib7 273 48 intracellular intracellular JJ cord-005453-4057qib7 273 49 cytokine cytokine NN cord-005453-4057qib7 273 50 - - HYPH cord-005453-4057qib7 273 51 assays assay NNS cord-005453-4057qib7 273 52 ) ) -RRB- cord-005453-4057qib7 273 53 . . . cord-005453-4057qib7 274 1 In in IN cord-005453-4057qib7 274 2 addition addition NN cord-005453-4057qib7 274 3 flowcytometric flowcytometric JJ cord-005453-4057qib7 274 4 evaluations evaluation NNS cord-005453-4057qib7 274 5 of of IN cord-005453-4057qib7 274 6 cellular cellular JJ cord-005453-4057qib7 274 7 and and CC cord-005453-4057qib7 274 8 ( ( -LRB- cord-005453-4057qib7 274 9 leukemia leukemia NN cord-005453-4057qib7 274 10 - - HYPH cord-005453-4057qib7 274 11 specific specific JJ cord-005453-4057qib7 274 12 ) ) -RRB- cord-005453-4057qib7 274 13 lymphocyte lymphocyte NN cord-005453-4057qib7 274 14 compositions composition NNS cord-005453-4057qib7 274 15 were be VBD cord-005453-4057qib7 274 16 performed perform VBN cord-005453-4057qib7 274 17 from from IN cord-005453-4057qib7 274 18 rats'/pts rats'/pt NNS cord-005453-4057qib7 274 19 ' ' POS cord-005453-4057qib7 274 20 blood blood NN cord-005453-4057qib7 274 21 in in IN cord-005453-4057qib7 274 22 the the DT cord-005453-4057qib7 274 23 course course NN cord-005453-4057qib7 274 24 of of IN cord-005453-4057qib7 274 25 the the DT cord-005453-4057qib7 274 26 disease disease NN cord-005453-4057qib7 274 27 . . . cord-005453-4057qib7 275 1 Results result NNS cord-005453-4057qib7 275 2 : : : cord-005453-4057qib7 275 3 1 1 LS cord-005453-4057qib7 275 4 ) ) -RRB- cord-005453-4057qib7 275 5 AML AML NNP cord-005453-4057qib7 275 6 - - HYPH cord-005453-4057qib7 275 7 diseased disease VBN cord-005453-4057qib7 275 8 rats rat NNS cord-005453-4057qib7 275 9 : : : cord-005453-4057qib7 275 10 each each DT cord-005453-4057qib7 275 11 3rats 3rats CD cord-005453-4057qib7 275 12 were be VBD cord-005453-4057qib7 275 13 treated treat VBN cord-005453-4057qib7 275 14 with with IN cord-005453-4057qib7 275 15 " " `` cord-005453-4057qib7 275 16 I -PRON- PRP cord-005453-4057qib7 275 17 " " '' cord-005453-4057qib7 275 18 , , , cord-005453-4057qib7 275 19 " " `` cord-005453-4057qib7 275 20 K K NNP cord-005453-4057qib7 275 21 " " '' cord-005453-4057qib7 275 22 or or CC cord-005453-4057qib7 275 23 " " `` cord-005453-4057qib7 275 24 M M NNP cord-005453-4057qib7 275 25 " " '' cord-005453-4057qib7 275 26 or or CC cord-005453-4057qib7 275 27 were be VBD cord-005453-4057qib7 275 28 untreated untreated JJ cord-005453-4057qib7 275 29 ( ( -LRB- cord-005453-4057qib7 275 30 controls control NNS cord-005453-4057qib7 275 31 ) ) -RRB- cord-005453-4057qib7 275 32 . . . cord-005453-4057qib7 276 1 A a DT cord-005453-4057qib7 276 2 significant significant JJ cord-005453-4057qib7 276 3 increase increase NN cord-005453-4057qib7 276 4 of of IN cord-005453-4057qib7 276 5 DCleu DCleu NNP cord-005453-4057qib7 276 6 could could MD cord-005453-4057qib7 276 7 be be VB cord-005453-4057qib7 276 8 detected detect VBN cord-005453-4057qib7 276 9 in in IN cord-005453-4057qib7 276 10 spleen spleen NN cord-005453-4057qib7 276 11 / / SYM cord-005453-4057qib7 276 12 PB PB NNP cord-005453-4057qib7 276 13 in in IN cord-005453-4057qib7 276 14 kit-(esp kit-(esp NNP cord-005453-4057qib7 276 15 . . . cord-005453-4057qib7 277 1 M M NNP cord-005453-4057qib7 277 2 ) ) -RRB- cord-005453-4057qib7 277 3 treated treat VBD cord-005453-4057qib7 277 4 compared compare VBN cord-005453-4057qib7 277 5 to to IN cord-005453-4057qib7 277 6 untreated untreated JJ cord-005453-4057qib7 277 7 animals animal NNS cord-005453-4057qib7 277 8 without without IN cord-005453-4057qib7 277 9 induction induction NN cord-005453-4057qib7 277 10 of of IN cord-005453-4057qib7 277 11 blasts blast NNS cord-005453-4057qib7 277 12 ' ' POS cord-005453-4057qib7 277 13 proliferation proliferation NN cord-005453-4057qib7 277 14 ( ( -LRB- cord-005453-4057qib7 277 15 Ki67positivity ki67positivity NN cord-005453-4057qib7 277 16 ) ) -RRB- cord-005453-4057qib7 278 1 : : : cord-005453-4057qib7 278 2 a a DT cord-005453-4057qib7 278 3 significant significant JJ cord-005453-4057qib7 278 4 reduction reduction NN cord-005453-4057qib7 278 5 of of IN cord-005453-4057qib7 278 6 blasts blast NNS cord-005453-4057qib7 278 7 was be VBD cord-005453-4057qib7 278 8 seen see VBN cord-005453-4057qib7 278 9 with with IN cord-005453-4057qib7 278 10 " " `` cord-005453-4057qib7 278 11 M M NNP cord-005453-4057qib7 278 12 " " '' cord-005453-4057qib7 278 13 ( ( -LRB- cord-005453-4057qib7 278 14 p=0.03/ p=0.03/ NNP cord-005453-4057qib7 278 15 0.0001 0.0001 CD cord-005453-4057qib7 278 16 in in IN cord-005453-4057qib7 278 17 spleen spleen NN cord-005453-4057qib7 278 18 / / SYM cord-005453-4057qib7 278 19 PB PB NNP cord-005453-4057qib7 278 20 ) ) -RRB- cord-005453-4057qib7 278 21 and and CC cord-005453-4057qib7 278 22 " " `` cord-005453-4057qib7 278 23 I -PRON- PRP cord-005453-4057qib7 278 24 " " '' cord-005453-4057qib7 278 25 , , , cord-005453-4057qib7 278 26 but but CC cord-005453-4057qib7 278 27 not not RB cord-005453-4057qib7 278 28 " " `` cord-005453-4057qib7 278 29 K K NNP cord-005453-4057qib7 278 30 " " '' cord-005453-4057qib7 278 31 . . . cord-005453-4057qib7 279 1 Successful successful JJ cord-005453-4057qib7 279 2 treatment treatment NN cord-005453-4057qib7 279 3 correlated correlate VBD cord-005453-4057qib7 279 4 with with IN cord-005453-4057qib7 279 5 an an DT cord-005453-4057qib7 279 6 increase increase NN cord-005453-4057qib7 279 7 of of IN cord-005453-4057qib7 279 8 CD62L+Tcells CD62L+Tcells NNPS cord-005453-4057qib7 279 9 , , , cord-005453-4057qib7 279 10 most most RBS cord-005453-4057qib7 279 11 likely likely RB cord-005453-4057qib7 279 12 representing represent VBG cord-005453-4057qib7 279 13 Tmem Tmem NNP cord-005453-4057qib7 279 14 - - HYPH cord-005453-4057qib7 279 15 cells cell NNS cord-005453-4057qib7 279 16 , , , cord-005453-4057qib7 279 17 ( ( -LRB- cord-005453-4057qib7 279 18 p=0.07 p=0.07 NNP cord-005453-4057qib7 279 19 ) ) -RRB- cord-005453-4057qib7 279 20 and and CC cord-005453-4057qib7 279 21 a a DT cord-005453-4057qib7 279 22 reduction reduction NN cord-005453-4057qib7 279 23 of of IN cord-005453-4057qib7 279 24 CD4+Treg CD4+Treg NNP cord-005453-4057qib7 279 25 ( ( -LRB- cord-005453-4057qib7 279 26 p=0.037 p=0.037 NNP cord-005453-4057qib7 279 27 ) ) -RRB- cord-005453-4057qib7 279 28 . . . cord-005453-4057qib7 280 1 2 2 LS cord-005453-4057qib7 280 2 ) ) -RRB- cord-005453-4057qib7 280 3 6 6 CD cord-005453-4057qib7 280 4 therapy therapy NN cord-005453-4057qib7 280 5 - - HYPH cord-005453-4057qib7 280 6 refractory refractory JJ cord-005453-4057qib7 280 7 AML AML NNP cord-005453-4057qib7 280 8 - - HYPH cord-005453-4057qib7 280 9 patients patient NNS cord-005453-4057qib7 280 10 ( ( -LRB- cord-005453-4057qib7 280 11 during during IN cord-005453-4057qib7 280 12 the the DT cord-005453-4057qib7 280 13 course course NN cord-005453-4057qib7 280 14 of of IN cord-005453-4057qib7 280 15 decitabine decitabine NNP cord-005453-4057qib7 280 16 / / SYM cord-005453-4057qib7 280 17 LD LD NNP cord-005453-4057qib7 280 18 - - HYPH cord-005453-4057qib7 280 19 AraCtreatment AraCtreatment NNP cord-005453-4057qib7 280 20 ) ) -RRB- cord-005453-4057qib7 280 21 : : : cord-005453-4057qib7 280 22 kit kit NN cord-005453-4057qib7 280 23 - - HYPH cord-005453-4057qib7 280 24 M M NNP cord-005453-4057qib7 280 25 was be VBD cord-005453-4057qib7 280 26 shown show VBN cord-005453-4057qib7 280 27 to to IN cord-005453-4057qib7 280 28 ex ex FW cord-005453-4057qib7 280 29 vivo vivo NN cord-005453-4057qib7 280 30 generate generate VB cord-005453-4057qib7 280 31 DCleu DCleu NNP cord-005453-4057qib7 280 32 , , , cord-005453-4057qib7 280 33 activate activate VB cord-005453-4057qib7 280 34 immunereactive immunereactive JJ cord-005453-4057qib7 280 35 cells cell NNS cord-005453-4057qib7 280 36 and and CC cord-005453-4057qib7 280 37 mediate mediate VB cord-005453-4057qib7 280 38 leukemia leukemia NN cord-005453-4057qib7 280 39 - - HYPH cord-005453-4057qib7 280 40 specific specific JJ cord-005453-4057qib7 280 41 / / SYM cord-005453-4057qib7 280 42 antileukemic antileukemic JJ cord-005453-4057qib7 280 43 response response NN cord-005453-4057qib7 280 44 . . . cord-005453-4057qib7 281 1 Activated activate VBN cord-005453-4057qib7 281 2 or or CC cord-005453-4057qib7 281 3 leukemia leukemia NN cord-005453-4057qib7 281 4 - - HYPH cord-005453-4057qib7 281 5 specific specific JJ cord-005453-4057qib7 281 6 lymphocytes lymphocyte NNS cord-005453-4057qib7 281 7 were be VBD cord-005453-4057qib7 281 8 monitored monitor VBN cord-005453-4057qib7 281 9 in in IN cord-005453-4057qib7 281 10 low low JJ cord-005453-4057qib7 281 11 proportions proportion NNS cord-005453-4057qib7 281 12 in in IN cord-005453-4057qib7 281 13 active active JJ cord-005453-4057qib7 281 14 stages stage NNS cord-005453-4057qib7 281 15 of of IN cord-005453-4057qib7 281 16 the the DT cord-005453-4057qib7 281 17 disease disease NN cord-005453-4057qib7 281 18 as as RB cord-005453-4057qib7 281 19 well well RB cord-005453-4057qib7 281 20 as as IN cord-005453-4057qib7 281 21 of of IN cord-005453-4057qib7 281 22 two two CD cord-005453-4057qib7 281 23 patients patient NNS cord-005453-4057qib7 281 24 during during IN cord-005453-4057qib7 281 25 the the DT cord-005453-4057qib7 281 26 further further JJ cord-005453-4057qib7 281 27 course course NN cord-005453-4057qib7 281 28 of of IN cord-005453-4057qib7 281 29 persisting persist VBG cord-005453-4057qib7 281 30 disease disease NN cord-005453-4057qib7 281 31 . . . cord-005453-4057qib7 282 1 One one CD cord-005453-4057qib7 282 2 of of IN cord-005453-4057qib7 282 3 these these DT cord-005453-4057qib7 282 4 patients patient NNS cord-005453-4057qib7 282 5 ( ( -LRB- cord-005453-4057qib7 282 6 72 72 CD cord-005453-4057qib7 282 7 yo yo NNP cord-005453-4057qib7 282 8 male male NNP cord-005453-4057qib7 282 9 ) ) -RRB- cord-005453-4057qib7 282 10 , , , cord-005453-4057qib7 282 11 was be VBD cord-005453-4057qib7 282 12 offered offer VBN cord-005453-4057qib7 282 13 an an DT cord-005453-4057qib7 282 14 individual individual JJ cord-005453-4057qib7 282 15 systemic systemic JJ cord-005453-4057qib7 282 16 salvage salvage NN cord-005453-4057qib7 282 17 - - HYPH cord-005453-4057qib7 282 18 treatment treatment NN cord-005453-4057qib7 282 19 ( ( -LRB- cord-005453-4057qib7 282 20 Kit Kit NNP cord-005453-4057qib7 282 21 - - HYPH cord-005453-4057qib7 282 22 M M NNP cord-005453-4057qib7 282 23 , , , cord-005453-4057qib7 282 24 applied apply VBD cord-005453-4057qib7 282 25 as as IN cord-005453-4057qib7 282 26 continuous continuous JJ cord-005453-4057qib7 282 27 infusions infusion NNS cord-005453-4057qib7 282 28 ) ) -RRB- cord-005453-4057qib7 282 29 for for IN cord-005453-4057qib7 282 30 refractory refractory JJ cord-005453-4057qib7 282 31 leukemia leukemia NN cord-005453-4057qib7 282 32 . . . cord-005453-4057qib7 283 1 after after IN cord-005453-4057qib7 283 2 approval approval NN cord-005453-4057qib7 283 3 from from IN cord-005453-4057qib7 283 4 the the DT cord-005453-4057qib7 283 5 local local JJ cord-005453-4057qib7 283 6 ethical ethical JJ cord-005453-4057qib7 283 7 commitee commitee NN cord-005453-4057qib7 283 8 , , , cord-005453-4057qib7 283 9 extensive extensive JJ cord-005453-4057qib7 283 10 information information NN cord-005453-4057qib7 283 11 of of IN cord-005453-4057qib7 283 12 the the DT cord-005453-4057qib7 283 13 patient patient NN cord-005453-4057qib7 283 14 about about IN cord-005453-4057qib7 283 15 the the DT cord-005453-4057qib7 283 16 experimental experimental JJ cord-005453-4057qib7 283 17 nature nature NN cord-005453-4057qib7 283 18 of of IN cord-005453-4057qib7 283 19 the the DT cord-005453-4057qib7 283 20 treatment treatment NN cord-005453-4057qib7 283 21 and and CC cord-005453-4057qib7 283 22 obtaining obtain VBG cord-005453-4057qib7 283 23 his -PRON- PRP$ cord-005453-4057qib7 283 24 written write VBN cord-005453-4057qib7 283 25 informed informed JJ cord-005453-4057qib7 283 26 consent consent NN cord-005453-4057qib7 283 27 . . . cord-005453-4057qib7 284 1 Clinically clinically RB cord-005453-4057qib7 284 2 the the DT cord-005453-4057qib7 284 3 treatment treatment NN cord-005453-4057qib7 284 4 was be VBD cord-005453-4057qib7 284 5 well well RB cord-005453-4057qib7 284 6 tolerated tolerate VBN cord-005453-4057qib7 284 7 and and CC cord-005453-4057qib7 284 8 the the DT cord-005453-4057qib7 284 9 patient patient NN cord-005453-4057qib7 284 10 improved improve VBD cord-005453-4057qib7 284 11 clinically clinically RB cord-005453-4057qib7 284 12 . . . cord-005453-4057qib7 285 1 Neutrophils Neutrophils NNP cord-005453-4057qib7 285 2 in in IN cord-005453-4057qib7 285 3 WBC WBC NNP cord-005453-4057qib7 285 4 increased increase VBD cord-005453-4057qib7 285 5 from from IN cord-005453-4057qib7 285 6 10 10 CD cord-005453-4057qib7 285 7 % % NN cord-005453-4057qib7 285 8 to to IN cord-005453-4057qib7 285 9 50 50 CD cord-005453-4057qib7 285 10 % % NN cord-005453-4057qib7 285 11 , , , cord-005453-4057qib7 285 12 thrombocytes thrombocyte NNS cord-005453-4057qib7 285 13 reached reach VBD cord-005453-4057qib7 285 14 100 100 CD cord-005453-4057qib7 285 15 G g NN cord-005453-4057qib7 285 16 / / SYM cord-005453-4057qib7 285 17 l l NN cord-005453-4057qib7 285 18 after after IN cord-005453-4057qib7 285 19 24 24 CD cord-005453-4057qib7 285 20 days day NNS cord-005453-4057qib7 285 21 . . . cord-005453-4057qib7 286 1 After after IN cord-005453-4057qib7 286 2 4 4 CD cord-005453-4057qib7 286 3 weeks week NNS cord-005453-4057qib7 286 4 of of IN cord-005453-4057qib7 286 5 treatment treatment NN cord-005453-4057qib7 286 6 , , , cord-005453-4057qib7 286 7 the the DT cord-005453-4057qib7 286 8 patient patient NN cord-005453-4057qib7 286 9 was be VBD cord-005453-4057qib7 286 10 discharged discharge VBN cord-005453-4057qib7 286 11 in in IN cord-005453-4057qib7 286 12 good good JJ cord-005453-4057qib7 286 13 clinical clinical JJ cord-005453-4057qib7 286 14 conditions condition NNS cord-005453-4057qib7 286 15 . . . cord-005453-4057qib7 287 1 12 12 CD cord-005453-4057qib7 287 2 days day NNS cord-005453-4057qib7 287 3 later later RB cord-005453-4057qib7 287 4 , , , cord-005453-4057qib7 287 5 progression progression NN cord-005453-4057qib7 287 6 of of IN cord-005453-4057qib7 287 7 AML AML NNP cord-005453-4057qib7 287 8 was be VBD cord-005453-4057qib7 287 9 seen see VBN cord-005453-4057qib7 287 10 with with IN cord-005453-4057qib7 287 11 high high JJ cord-005453-4057qib7 287 12 blast blast NN cord-005453-4057qib7 287 13 counts count NNS cord-005453-4057qib7 287 14 in in IN cord-005453-4057qib7 287 15 PB PB NNP cord-005453-4057qib7 287 16 and and CC cord-005453-4057qib7 287 17 BM BM NNP cord-005453-4057qib7 287 18 . . . cord-005453-4057qib7 288 1 The the DT cord-005453-4057qib7 288 2 patient patient NN cord-005453-4057qib7 288 3 developed develop VBD cord-005453-4057qib7 288 4 severe severe JJ cord-005453-4057qib7 288 5 sepsis sepsis NN cord-005453-4057qib7 288 6 and and CC cord-005453-4057qib7 288 7 died die VBD cord-005453-4057qib7 288 8 few few JJ cord-005453-4057qib7 288 9 days day NNS cord-005453-4057qib7 288 10 later later RB cord-005453-4057qib7 288 11 . . . cord-005453-4057qib7 289 1 Immune immune JJ cord-005453-4057qib7 289 2 monitoring monitoring NN cord-005453-4057qib7 289 3 showed show VBD cord-005453-4057qib7 289 4 ( ( -LRB- cord-005453-4057qib7 289 5 other other JJ cord-005453-4057qib7 289 6 than than IN cord-005453-4057qib7 289 7 before before IN cord-005453-4057qib7 289 8 treatment treatment NN cord-005453-4057qib7 289 9 and and CC cord-005453-4057qib7 289 10 in in IN cord-005453-4057qib7 289 11 the the DT cord-005453-4057qib7 289 12 patients patient NNS cord-005453-4057qib7 289 13 without without IN cord-005453-4057qib7 289 14 kit kit NN cord-005453-4057qib7 289 15 - - HYPH cord-005453-4057qib7 289 16 M m NN cord-005453-4057qib7 289 17 - - HYPH cord-005453-4057qib7 289 18 treatment treatment NN cord-005453-4057qib7 289 19 ) ) -RRB- cord-005453-4057qib7 289 20 a a DT cord-005453-4057qib7 289 21 continuous continuous JJ cord-005453-4057qib7 289 22 increase increase NN cord-005453-4057qib7 289 23 of of IN cord-005453-4057qib7 289 24 proliferating proliferate VBG cord-005453-4057qib7 289 25 and and CC cord-005453-4057qib7 289 26 non non JJ cord-005453-4057qib7 289 27 - - JJ cord-005453-4057qib7 289 28 naïve naïve JJ cord-005453-4057qib7 289 29 Tcells Tcells NNP cord-005453-4057qib7 289 30 , , , cord-005453-4057qib7 289 31 NK NK NNP cord-005453-4057qib7 289 32 , , , cord-005453-4057qib7 290 1 CIKand CIKand NNP cord-005453-4057qib7 290 2 NKT- NKT- NNP cord-005453-4057qib7 290 3 , , , cord-005453-4057qib7 290 4 TH17 TH17 NNP cord-005453-4057qib7 290 5 cells cell NNS cord-005453-4057qib7 290 6 , , , cord-005453-4057qib7 290 7 Bmem Bmem NNP cord-005453-4057qib7 290 8 - - HYPH cord-005453-4057qib7 290 9 cells cell NNS cord-005453-4057qib7 290 10 and and CC cord-005453-4057qib7 290 11 DC DC NNP cord-005453-4057qib7 290 12 in in IN cord-005453-4057qib7 290 13 PB PB NNP cord-005453-4057qib7 290 14 . . . cord-005453-4057qib7 291 1 The the DT cord-005453-4057qib7 291 2 production production NN cord-005453-4057qib7 291 3 of of IN cord-005453-4057qib7 291 4 IFNƔ IFNƔ NNP cord-005453-4057qib7 291 5 producing produce VBG cord-005453-4057qib7 291 6 T- T- NNP cord-005453-4057qib7 291 7 , , , cord-005453-4057qib7 291 8 CIK CIK NNP cord-005453-4057qib7 291 9 and and CC cord-005453-4057qib7 291 10 NKT NKT NNP cord-005453-4057qib7 291 11 - - HYPH cord-005453-4057qib7 291 12 cells cell NNS cord-005453-4057qib7 291 13 was be VBD cord-005453-4057qib7 291 14 demonstrated demonstrate VBN cord-005453-4057qib7 291 15 , , , cord-005453-4057qib7 291 16 suggesting suggest VBG cord-005453-4057qib7 291 17 an an DT cord-005453-4057qib7 291 18 in in IN cord-005453-4057qib7 291 19 vivo vivo NN cord-005453-4057qib7 291 20 production production NN cord-005453-4057qib7 291 21 / / SYM cord-005453-4057qib7 291 22 activation activation NN cord-005453-4057qib7 291 23 of of IN cord-005453-4057qib7 291 24 ( ( -LRB- cord-005453-4057qib7 291 25 potentially potentially RB cord-005453-4057qib7 291 26 leukemia leukemia NN cord-005453-4057qib7 291 27 - - HYPH cord-005453-4057qib7 291 28 specific specific JJ cord-005453-4057qib7 291 29 ) ) -RRB- cord-005453-4057qib7 291 30 cells cell NNS cord-005453-4057qib7 291 31 . . . cord-005453-4057qib7 292 1 Immune immune JJ cord-005453-4057qib7 292 2 stimulatory stimulatory JJ cord-005453-4057qib7 292 3 effects effect NNS cord-005453-4057qib7 292 4 decreased decrease VBD cord-005453-4057qib7 292 5 after after IN cord-005453-4057qib7 292 6 discontinuation discontinuation NN cord-005453-4057qib7 292 7 of of IN cord-005453-4057qib7 292 8 therapy therapy NN cord-005453-4057qib7 292 9 . . . cord-005453-4057qib7 293 1 Conclusions conclusion NNS cord-005453-4057qib7 293 2 : : : cord-005453-4057qib7 294 1 Treatment treatment NN cord-005453-4057qib7 294 2 of of IN cord-005453-4057qib7 294 3 WB WB NNP cord-005453-4057qib7 294 4 as as RB cord-005453-4057qib7 294 5 well well RB cord-005453-4057qib7 294 6 as as IN cord-005453-4057qib7 294 7 leukemically leukemically RB cord-005453-4057qib7 294 8 diseased disease VBN cord-005453-4057qib7 294 9 organisms organism NNS cord-005453-4057qib7 294 10 with with IN cord-005453-4057qib7 294 11 blast blast NN cord-005453-4057qib7 294 12 - - HYPH cord-005453-4057qib7 294 13 modulating modulate VBG cord-005453-4057qib7 294 14 kits kit NNS cord-005453-4057qib7 294 15 ( ( -LRB- cord-005453-4057qib7 294 16 especially especially RB cord-005453-4057qib7 294 17 GM GM NNP cord-005453-4057qib7 294 18 - - HYPH cord-005453-4057qib7 294 19 CSF CSF NNP cord-005453-4057qib7 294 20 and and CC cord-005453-4057qib7 294 21 PGE1 PGE1 NNP cord-005453-4057qib7 294 22 ) ) -RRB- cord-005453-4057qib7 294 23 was be VBD cord-005453-4057qib7 294 24 well well RB cord-005453-4057qib7 294 25 tolerated tolerate VBN cord-005453-4057qib7 294 26 and and CC cord-005453-4057qib7 294 27 induced induce VBN cord-005453-4057qib7 294 28 clinical clinical JJ cord-005453-4057qib7 294 29 and and CC cord-005453-4057qib7 294 30 immunological immunological JJ cord-005453-4057qib7 294 31 improvement improvement NN cord-005453-4057qib7 294 32 ( ( -LRB- cord-005453-4057qib7 294 33 adaptive adaptive JJ cord-005453-4057qib7 294 34 and and CC cord-005453-4057qib7 294 35 innate innate JJ cord-005453-4057qib7 294 36 immune immune JJ cord-005453-4057qib7 294 37 system system NN cord-005453-4057qib7 294 38 ) ) -RRB- cord-005453-4057qib7 294 39 , , , cord-005453-4057qib7 294 40 whereas whereas IN cord-005453-4057qib7 294 41 low low JJ cord-005453-4057qib7 294 42 counts count NNS cord-005453-4057qib7 294 43 of of IN cord-005453-4057qib7 294 44 ( ( -LRB- cord-005453-4057qib7 294 45 leukemiaspecific leukemiaspecific NN cord-005453-4057qib7 294 46 ) ) -RRB- cord-005453-4057qib7 294 47 activated activate VBN cord-005453-4057qib7 294 48 immune immune NN cord-005453-4057qib7 294 49 - - HYPH cord-005453-4057qib7 294 50 reactive reactive JJ cord-005453-4057qib7 294 51 cells cell NNS cord-005453-4057qib7 294 52 were be VBD cord-005453-4057qib7 294 53 found find VBN cord-005453-4057qib7 294 54 in in IN cord-005453-4057qib7 294 55 non non JJ cord-005453-4057qib7 294 56 - - JJ cord-005453-4057qib7 294 57 kit kit RB cord-005453-4057qib7 294 58 - - HYPH cord-005453-4057qib7 294 59 treated treat VBN cord-005453-4057qib7 294 60 organisms organism NNS cord-005453-4057qib7 294 61 . . . cord-005453-4057qib7 295 1 Disclosure disclosure NN cord-005453-4057qib7 295 2 : : : cord-005453-4057qib7 295 3 Nothing nothing NN cord-005453-4057qib7 295 4 to to TO cord-005453-4057qib7 295 5 declare declare VB cord-005453-4057qib7 295 6 P019 P019 NNP cord-005453-4057qib7 295 7 Long long JJ cord-005453-4057qib7 295 8 - - HYPH cord-005453-4057qib7 295 9 term term NN cord-005453-4057qib7 295 10 outcomes outcome NNS cord-005453-4057qib7 295 11 after after IN cord-005453-4057qib7 295 12 allogeneic allogeneic JJ cord-005453-4057qib7 295 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 295 14 stem stem NN cord-005453-4057qib7 295 15 cell cell NN cord-005453-4057qib7 295 16 transplantation transplantation NN cord-005453-4057qib7 295 17 for for IN cord-005453-4057qib7 295 18 acute acute JJ cord-005453-4057qib7 295 19 myeloid myeloid JJ cord-005453-4057qib7 295 20 leukemia leukemia NN cord-005453-4057qib7 295 21 with with IN cord-005453-4057qib7 295 22 non non JJ cord-005453-4057qib7 295 23 - - JJ cord-005453-4057qib7 295 24 myeloablative myeloablative JJ cord-005453-4057qib7 295 25 and and CC cord-005453-4057qib7 295 26 myeloablative myeloablative JJ cord-005453-4057qib7 295 27 conditioning conditioning NN cord-005453-4057qib7 295 28 : : : cord-005453-4057qib7 295 29 A a DT cord-005453-4057qib7 295 30 single single JJ cord-005453-4057qib7 295 31 - - HYPH cord-005453-4057qib7 295 32 center center NN cord-005453-4057qib7 295 33 cohort cohort NN cord-005453-4057qib7 295 34 study study NN cord-005453-4057qib7 295 35 of of IN cord-005453-4057qib7 295 36 438 438 CD cord-005453-4057qib7 295 37 consecutive consecutive JJ cord-005453-4057qib7 295 38 patients patient NNS cord-005453-4057qib7 295 39 1Lars 1lars CD cord-005453-4057qib7 295 40 Klingen Klingen NNP cord-005453-4057qib7 295 41 Gjaerde Gjaerde NNP cord-005453-4057qib7 295 42 , , , cord-005453-4057qib7 295 43 Niels Niels NNP cord-005453-4057qib7 295 44 Smedegaard Smedegaard NNP cord-005453-4057qib7 295 45 Andersen Andersen NNP cord-005453-4057qib7 295 46 1 1 CD cord-005453-4057qib7 295 47 , , , cord-005453-4057qib7 295 48 Lone Lone NNP cord-005453-4057qib7 295 49 Smidstrup Smidstrup NNP cord-005453-4057qib7 295 50 Friis Friis NNP cord-005453-4057qib7 295 51 1 1 CD cord-005453-4057qib7 295 52 , , , cord-005453-4057qib7 295 53 Brian Brian NNP cord-005453-4057qib7 295 54 Thomas Thomas NNP cord-005453-4057qib7 295 55 Kornblit Kornblit NNP cord-005453-4057qib7 295 56 1 1 CD cord-005453-4057qib7 295 57 , , , cord-005453-4057qib7 295 58 Søren Søren NNP cord-005453-4057qib7 295 59 Lykke Lykke NNP cord-005453-4057qib7 295 60 Petersen Petersen NNP cord-005453-4057qib7 295 61 1 1 CD cord-005453-4057qib7 295 62 , , , cord-005453-4057qib7 295 63 Ida Ida NNP cord-005453-4057qib7 295 64 Schjødt Schjødt NNP cord-005453-4057qib7 295 65 1 1 CD cord-005453-4057qib7 295 66 , , , cord-005453-4057qib7 295 67 Henrik Henrik NNP cord-005453-4057qib7 295 68 Sengeløv Sengeløv NNP cord-005453-4057qib7 296 1 1 1 CD cord-005453-4057qib7 296 2 1 1 CD cord-005453-4057qib7 296 3 Rigshospitalet Rigshospitalet NNP cord-005453-4057qib7 296 4 , , , cord-005453-4057qib7 296 5 Copenhagen Copenhagen NNP cord-005453-4057qib7 296 6 , , , cord-005453-4057qib7 296 7 Denmark Denmark NNP cord-005453-4057qib7 296 8 Background Background NNP cord-005453-4057qib7 296 9 : : : cord-005453-4057qib7 296 10 Since since IN cord-005453-4057qib7 296 11 2000 2000 CD cord-005453-4057qib7 296 12 , , , cord-005453-4057qib7 296 13 we -PRON- PRP cord-005453-4057qib7 296 14 have have VBP cord-005453-4057qib7 296 15 at at IN cord-005453-4057qib7 296 16 our -PRON- PRP$ cord-005453-4057qib7 296 17 institution institution NN cord-005453-4057qib7 296 18 used use VBD cord-005453-4057qib7 296 19 a a DT cord-005453-4057qib7 296 20 non non JJ cord-005453-4057qib7 296 21 - - JJ cord-005453-4057qib7 296 22 myeloablative myeloablative JJ cord-005453-4057qib7 296 23 ( ( -LRB- cord-005453-4057qib7 296 24 NMA NMA NNP cord-005453-4057qib7 296 25 ) ) -RRB- cord-005453-4057qib7 296 26 conditioning conditioning NN cord-005453-4057qib7 296 27 regimen regimen NN cord-005453-4057qib7 296 28 for for IN cord-005453-4057qib7 296 29 older old JJR cord-005453-4057qib7 296 30 ( ( -LRB- cord-005453-4057qib7 296 31 > > NFP cord-005453-4057qib7 296 32 50 50 CD cord-005453-4057qib7 296 33 years year NNS cord-005453-4057qib7 296 34 ) ) -RRB- cord-005453-4057qib7 296 35 or or CC cord-005453-4057qib7 296 36 significantly significantly RB cord-005453-4057qib7 296 37 comorbid comorbid VBG cord-005453-4057qib7 296 38 younger young JJR cord-005453-4057qib7 296 39 patients patient NNS cord-005453-4057qib7 296 40 undergoing undergo VBG cord-005453-4057qib7 296 41 allogeneic allogeneic IN cord-005453-4057qib7 296 42 hematopoietic hematopoietic JJ cord-005453-4057qib7 296 43 stem stem NN cord-005453-4057qib7 296 44 cell cell NN cord-005453-4057qib7 296 45 transplantation transplantation NN cord-005453-4057qib7 296 46 ( ( -LRB- cord-005453-4057qib7 296 47 allo allo NN cord-005453-4057qib7 296 48 - - HYPH cord-005453-4057qib7 296 49 HSCT HSCT NNP cord-005453-4057qib7 296 50 ) ) -RRB- cord-005453-4057qib7 296 51 for for IN cord-005453-4057qib7 296 52 acute acute JJ cord-005453-4057qib7 296 53 myeloid myeloid JJ cord-005453-4057qib7 296 54 leukemia leukemia NN cord-005453-4057qib7 296 55 ( ( -LRB- cord-005453-4057qib7 296 56 AML AML NNP cord-005453-4057qib7 296 57 ) ) -RRB- cord-005453-4057qib7 296 58 . . . cord-005453-4057qib7 297 1 We -PRON- PRP cord-005453-4057qib7 297 2 aimed aim VBD cord-005453-4057qib7 297 3 to to TO cord-005453-4057qib7 297 4 compare compare VB cord-005453-4057qib7 297 5 the the DT cord-005453-4057qib7 297 6 long long JJ cord-005453-4057qib7 297 7 - - HYPH cord-005453-4057qib7 297 8 term term NN cord-005453-4057qib7 297 9 outcomes outcome NNS cord-005453-4057qib7 297 10 of of IN cord-005453-4057qib7 297 11 NMA NMA NNP cord-005453-4057qib7 297 12 conditioned condition VBD cord-005453-4057qib7 297 13 patients patient NNS cord-005453-4057qib7 297 14 with with IN cord-005453-4057qib7 297 15 myeloablative myeloablative NNP cord-005453-4057qib7 297 16 ( ( -LRB- cord-005453-4057qib7 297 17 MA MA NNP cord-005453-4057qib7 297 18 ) ) -RRB- cord-005453-4057qib7 297 19 conditioned condition VBD cord-005453-4057qib7 297 20 patients patient NNS cord-005453-4057qib7 297 21 . . . cord-005453-4057qib7 298 1 Methods method NNS cord-005453-4057qib7 298 2 : : : cord-005453-4057qib7 299 1 We -PRON- PRP cord-005453-4057qib7 299 2 studied study VBD cord-005453-4057qib7 299 3 220 220 CD cord-005453-4057qib7 299 4 NMA NMA NNP cord-005453-4057qib7 299 5 and and CC cord-005453-4057qib7 299 6 218 218 CD cord-005453-4057qib7 299 7 MA MA NNP cord-005453-4057qib7 299 8 conditioned condition VBN cord-005453-4057qib7 299 9 adult adult NN cord-005453-4057qib7 299 10 ( ( -LRB- cord-005453-4057qib7 299 11 > > NFP cord-005453-4057qib7 299 12 15 15 CD cord-005453-4057qib7 299 13 years year NNS cord-005453-4057qib7 299 14 ) ) -RRB- cord-005453-4057qib7 299 15 consecutive consecutive JJ cord-005453-4057qib7 299 16 patients patient NNS cord-005453-4057qib7 299 17 receiving receive VBG cord-005453-4057qib7 299 18 their -PRON- PRP$ cord-005453-4057qib7 299 19 first first JJ cord-005453-4057qib7 299 20 allo allo NN cord-005453-4057qib7 299 21 - - HYPH cord-005453-4057qib7 299 22 HSCT HSCT NNP cord-005453-4057qib7 299 23 for for IN cord-005453-4057qib7 299 24 AML AML NNP cord-005453-4057qib7 299 25 from from IN cord-005453-4057qib7 299 26 2000 2000 CD cord-005453-4057qib7 299 27 to to IN cord-005453-4057qib7 299 28 2017 2017 CD cord-005453-4057qib7 299 29 at at IN cord-005453-4057qib7 299 30 Rigshospitalet Rigshospitalet NNP cord-005453-4057qib7 299 31 . . . cord-005453-4057qib7 300 1 NMA NMA NNP cord-005453-4057qib7 300 2 conditioning conditioning NN cord-005453-4057qib7 300 3 consisted consist VBD cord-005453-4057qib7 300 4 mainly mainly RB cord-005453-4057qib7 300 5 of of IN cord-005453-4057qib7 300 6 2 2 CD cord-005453-4057qib7 300 7 Gy Gy NNP cord-005453-4057qib7 300 8 total total JJ cord-005453-4057qib7 300 9 body body NN cord-005453-4057qib7 300 10 irradiation irradiation NN cord-005453-4057qib7 300 11 ( ( -LRB- cord-005453-4057qib7 300 12 TBI TBI NNP cord-005453-4057qib7 300 13 ) ) -RRB- cord-005453-4057qib7 300 14 and and CC cord-005453-4057qib7 300 15 fludarabine fludarabine VBP cord-005453-4057qib7 300 16 90 90 CD cord-005453-4057qib7 300 17 mg mg NNP cord-005453-4057qib7 300 18 / / SYM cord-005453-4057qib7 300 19 m m NN cord-005453-4057qib7 300 20 2 2 CD cord-005453-4057qib7 300 21 ( ( -LRB- cord-005453-4057qib7 300 22 95 95 CD cord-005453-4057qib7 300 23 % % NN cord-005453-4057qib7 300 24 of of IN cord-005453-4057qib7 300 25 cases case NNS cord-005453-4057qib7 300 26 ) ) -RRB- cord-005453-4057qib7 300 27 . . . cord-005453-4057qib7 301 1 MA MA NNP cord-005453-4057qib7 301 2 conditioning conditioning NN cord-005453-4057qib7 301 3 consisted consist VBD cord-005453-4057qib7 301 4 mainly mainly RB cord-005453-4057qib7 301 5 of of IN cord-005453-4057qib7 301 6 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 301 7 120 120 CD cord-005453-4057qib7 301 8 mg/ mg/ NN cord-005453-4057qib7 301 9 kg kg NN cord-005453-4057qib7 301 10 and and CC cord-005453-4057qib7 301 11 either either DT cord-005453-4057qib7 301 12 12 12 CD cord-005453-4057qib7 301 13 Gy Gy NNP cord-005453-4057qib7 301 14 TBI TBI NNP cord-005453-4057qib7 301 15 ( ( -LRB- cord-005453-4057qib7 301 16 86 86 CD cord-005453-4057qib7 301 17 % % NN cord-005453-4057qib7 301 18 of of IN cord-005453-4057qib7 301 19 cases case NNS cord-005453-4057qib7 301 20 ) ) -RRB- cord-005453-4057qib7 301 21 or or CC cord-005453-4057qib7 301 22 busulfan busulfan NNP cord-005453-4057qib7 301 23 12.8 12.8 CD cord-005453-4057qib7 301 24 mg/ mg/ NNP cord-005453-4057qib7 301 25 kg kg NNP cord-005453-4057qib7 301 26 ( ( -LRB- cord-005453-4057qib7 301 27 5 5 CD cord-005453-4057qib7 301 28 % % NN cord-005453-4057qib7 301 29 of of IN cord-005453-4057qib7 301 30 cases case NNS cord-005453-4057qib7 301 31 ) ) -RRB- cord-005453-4057qib7 301 32 , , , cord-005453-4057qib7 301 33 or or CC cord-005453-4057qib7 301 34 fludarabine fludarabine VB cord-005453-4057qib7 301 35 150 150 CD cord-005453-4057qib7 301 36 mg mg NNP cord-005453-4057qib7 301 37 / / SYM cord-005453-4057qib7 301 38 m m NNP cord-005453-4057qib7 301 39 2 2 CD cord-005453-4057qib7 301 40 and and CC cord-005453-4057qib7 301 41 treosulfan treosulfan NNP cord-005453-4057qib7 301 42 42 42 CD cord-005453-4057qib7 301 43 mg mg NNP cord-005453-4057qib7 301 44 / / SYM cord-005453-4057qib7 301 45 m m NN cord-005453-4057qib7 301 46 2 2 CD cord-005453-4057qib7 301 47 ( ( -LRB- cord-005453-4057qib7 301 48 6 6 CD cord-005453-4057qib7 301 49 % % NN cord-005453-4057qib7 301 50 of of IN cord-005453-4057qib7 301 51 cases case NNS cord-005453-4057qib7 301 52 ) ) -RRB- cord-005453-4057qib7 301 53 . . . cord-005453-4057qib7 302 1 Five five CD cord-005453-4057qib7 302 2 percent percent NN cord-005453-4057qib7 302 3 and and CC cord-005453-4057qib7 302 4 19 19 CD cord-005453-4057qib7 302 5 % % NN cord-005453-4057qib7 302 6 of of IN cord-005453-4057qib7 302 7 NMA NMA NNP cord-005453-4057qib7 302 8 and and CC cord-005453-4057qib7 302 9 MA MA NNP cord-005453-4057qib7 302 10 conditioned condition VBD cord-005453-4057qib7 302 11 patients patient NNS cord-005453-4057qib7 302 12 , , , cord-005453-4057qib7 302 13 respectively respectively RB cord-005453-4057qib7 302 14 , , , cord-005453-4057qib7 302 15 received receive VBD cord-005453-4057qib7 302 16 anti anti JJ cord-005453-4057qib7 302 17 - - JJ cord-005453-4057qib7 302 18 thymocyte thymocyte JJ cord-005453-4057qib7 302 19 globulin globulin NN cord-005453-4057qib7 302 20 . . . cord-005453-4057qib7 303 1 Patients patient NNS cord-005453-4057qib7 303 2 were be VBD cord-005453-4057qib7 303 3 followed follow VBN cord-005453-4057qib7 303 4 until until IN cord-005453-4057qib7 303 5 death death NN cord-005453-4057qib7 303 6 or or CC cord-005453-4057qib7 303 7 end end NN cord-005453-4057qib7 303 8 - - HYPH cord-005453-4057qib7 303 9 of of IN cord-005453-4057qib7 303 10 - - HYPH cord-005453-4057qib7 303 11 followup followup NN cord-005453-4057qib7 303 12 on on IN cord-005453-4057qib7 303 13 October October NNP cord-005453-4057qib7 303 14 31 31 CD cord-005453-4057qib7 303 15 st st NNP cord-005453-4057qib7 303 16 , , , cord-005453-4057qib7 303 17 2018 2018 CD cord-005453-4057qib7 303 18 . . . cord-005453-4057qib7 304 1 Cumulative cumulative JJ cord-005453-4057qib7 304 2 incidences incidence NNS cord-005453-4057qib7 304 3 with with IN cord-005453-4057qib7 304 4 95 95 CD cord-005453-4057qib7 304 5 % % NN cord-005453-4057qib7 304 6 confidence confidence NN cord-005453-4057qib7 304 7 intervals interval NNS cord-005453-4057qib7 304 8 ( ( -LRB- cord-005453-4057qib7 304 9 CI CI NNP cord-005453-4057qib7 304 10 ) ) -RRB- cord-005453-4057qib7 304 11 of of IN cord-005453-4057qib7 304 12 acute acute JJ cord-005453-4057qib7 304 13 graft graft NN cord-005453-4057qib7 304 14 - - HYPH cord-005453-4057qib7 304 15 versus versus IN cord-005453-4057qib7 304 16 - - HYPH cord-005453-4057qib7 304 17 host host NN cord-005453-4057qib7 304 18 disease disease NN cord-005453-4057qib7 304 19 ( ( -LRB- cord-005453-4057qib7 304 20 aGVHD aGVHD NNP cord-005453-4057qib7 304 21 ) ) -RRB- cord-005453-4057qib7 304 22 grade grade NN cord-005453-4057qib7 304 23 II II NNP cord-005453-4057qib7 304 24 - - HYPH cord-005453-4057qib7 304 25 IV IV NNP cord-005453-4057qib7 304 26 , , , cord-005453-4057qib7 304 27 chronic chronic JJ cord-005453-4057qib7 304 28 graft graft NN cord-005453-4057qib7 304 29 - - HYPH cord-005453-4057qib7 304 30 versus versus IN cord-005453-4057qib7 304 31 - - HYPH cord-005453-4057qib7 304 32 host host NN cord-005453-4057qib7 304 33 disease disease NN cord-005453-4057qib7 304 34 ( ( -LRB- cord-005453-4057qib7 304 35 cGVHD cGVHD NNP cord-005453-4057qib7 304 36 ) ) -RRB- cord-005453-4057qib7 304 37 , , , cord-005453-4057qib7 304 38 relapse relapse NN cord-005453-4057qib7 304 39 and and CC cord-005453-4057qib7 304 40 non non JJ cord-005453-4057qib7 304 41 - - JJ cord-005453-4057qib7 304 42 relapse relapse JJ cord-005453-4057qib7 304 43 mortality mortality NN cord-005453-4057qib7 304 44 ( ( -LRB- cord-005453-4057qib7 304 45 NRM NRM NNP cord-005453-4057qib7 304 46 ) ) -RRB- cord-005453-4057qib7 304 47 were be VBD cord-005453-4057qib7 304 48 calculated calculate VBN cord-005453-4057qib7 304 49 and and CC cord-005453-4057qib7 304 50 compared compare VBN cord-005453-4057qib7 304 51 between between IN cord-005453-4057qib7 304 52 NMA NMA NNP cord-005453-4057qib7 304 53 and and CC cord-005453-4057qib7 304 54 MA MA NNP cord-005453-4057qib7 304 55 conditioned condition VBD cord-005453-4057qib7 304 56 patients patient NNS cord-005453-4057qib7 304 57 using use VBG cord-005453-4057qib7 304 58 Gray Gray NNP cord-005453-4057qib7 304 59 's 's POS cord-005453-4057qib7 304 60 test test NN cord-005453-4057qib7 304 61 with with IN cord-005453-4057qib7 304 62 death death NN cord-005453-4057qib7 304 63 as as IN cord-005453-4057qib7 304 64 a a DT cord-005453-4057qib7 304 65 competing compete VBG cord-005453-4057qib7 304 66 risk risk NN cord-005453-4057qib7 304 67 ( ( -LRB- cord-005453-4057qib7 304 68 or or CC cord-005453-4057qib7 304 69 relapse relapse VB cord-005453-4057qib7 304 70 when when WRB cord-005453-4057qib7 304 71 comparing compare VBG cord-005453-4057qib7 304 72 NRM NRM NNP cord-005453-4057qib7 304 73 ) ) -RRB- cord-005453-4057qib7 304 74 . . . cord-005453-4057qib7 305 1 Overall overall JJ cord-005453-4057qib7 305 2 survival survival NN cord-005453-4057qib7 305 3 ( ( -LRB- cord-005453-4057qib7 305 4 OS OS NNP cord-005453-4057qib7 305 5 ) ) -RRB- cord-005453-4057qib7 305 6 was be VBD cord-005453-4057qib7 305 7 estimated estimate VBN cord-005453-4057qib7 305 8 by by IN cord-005453-4057qib7 305 9 the the DT cord-005453-4057qib7 305 10 Kaplan Kaplan NNP cord-005453-4057qib7 305 11 - - HYPH cord-005453-4057qib7 305 12 Meier Meier NNP cord-005453-4057qib7 305 13 method method NN cord-005453-4057qib7 305 14 . . . cord-005453-4057qib7 306 1 Results result NNS cord-005453-4057qib7 306 2 : : : cord-005453-4057qib7 307 1 NMA NMA NNP cord-005453-4057qib7 307 2 and and CC cord-005453-4057qib7 307 3 MA MA NNP cord-005453-4057qib7 307 4 conditioned condition VBD cord-005453-4057qib7 307 5 patients patient NNS cord-005453-4057qib7 307 6 were be VBD cord-005453-4057qib7 307 7 comparable comparable JJ cord-005453-4057qib7 307 8 when when WRB cord-005453-4057qib7 307 9 regarding regard VBG cord-005453-4057qib7 307 10 sex sex NN cord-005453-4057qib7 307 11 ( ( -LRB- cord-005453-4057qib7 307 12 49 49 CD cord-005453-4057qib7 307 13 % % NN cord-005453-4057qib7 307 14 and and CC cord-005453-4057qib7 307 15 48 48 CD cord-005453-4057qib7 307 16 % % NN cord-005453-4057qib7 307 17 female female NN cord-005453-4057qib7 307 18 , , , cord-005453-4057qib7 307 19 respectively respectively RB cord-005453-4057qib7 307 20 ) ) -RRB- cord-005453-4057qib7 307 21 and and CC cord-005453-4057qib7 307 22 donor donor NN cord-005453-4057qib7 307 23 ( ( -LRB- cord-005453-4057qib7 307 24 matched match VBN cord-005453-4057qib7 307 25 related related JJ cord-005453-4057qib7 307 26 donor donor NN cord-005453-4057qib7 307 27 in in IN cord-005453-4057qib7 307 28 34 34 CD cord-005453-4057qib7 307 29 % % NN cord-005453-4057qib7 307 30 and and CC cord-005453-4057qib7 307 31 36 36 CD cord-005453-4057qib7 307 32 % % NN cord-005453-4057qib7 307 33 , , , cord-005453-4057qib7 307 34 respectively respectively RB cord-005453-4057qib7 307 35 ) ) -RRB- cord-005453-4057qib7 307 36 , , , cord-005453-4057qib7 307 37 but but CC cord-005453-4057qib7 307 38 differed differ VBD cord-005453-4057qib7 307 39 , , , cord-005453-4057qib7 307 40 as as IN cord-005453-4057qib7 307 41 expected expect VBN cord-005453-4057qib7 307 42 by by IN cord-005453-4057qib7 307 43 indication indication NN cord-005453-4057qib7 307 44 , , , cord-005453-4057qib7 307 45 with with IN cord-005453-4057qib7 307 46 regards regard NNS cord-005453-4057qib7 307 47 to to IN cord-005453-4057qib7 307 48 age age NN cord-005453-4057qib7 307 49 ( ( -LRB- cord-005453-4057qib7 307 50 median median NN cord-005453-4057qib7 307 51 of of IN cord-005453-4057qib7 307 52 60 60 CD cord-005453-4057qib7 307 53 versus versus IN cord-005453-4057qib7 307 54 42 42 CD cord-005453-4057qib7 307 55 years year NNS cord-005453-4057qib7 307 56 , , , cord-005453-4057qib7 307 57 respectively respectively RB cord-005453-4057qib7 307 58 ) ) -RRB- cord-005453-4057qib7 307 59 and and CC cord-005453-4057qib7 307 60 Karnofsky Karnofsky NNP cord-005453-4057qib7 307 61 score score NN cord-005453-4057qib7 307 62 ( ( -LRB- cord-005453-4057qib7 308 1 < < XX cord-005453-4057qib7 308 2 90 90 CD cord-005453-4057qib7 308 3 in in IN cord-005453-4057qib7 308 4 18 18 CD cord-005453-4057qib7 308 5 % % NN cord-005453-4057qib7 308 6 and and CC cord-005453-4057qib7 308 7 11 11 CD cord-005453-4057qib7 308 8 % % NN cord-005453-4057qib7 308 9 , , , cord-005453-4057qib7 308 10 respectively respectively RB cord-005453-4057qib7 308 11 ) ) -RRB- cord-005453-4057qib7 308 12 . . . cord-005453-4057qib7 309 1 NMA NMA NNP cord-005453-4057qib7 309 2 conditioned condition VBD cord-005453-4057qib7 309 3 patients patient NNS cord-005453-4057qib7 309 4 had have VBD cord-005453-4057qib7 309 5 generally generally RB cord-005453-4057qib7 309 6 a a DT cord-005453-4057qib7 309 7 lower low JJR cord-005453-4057qib7 309 8 AML AML NNP cord-005453-4057qib7 309 9 stage stage NN cord-005453-4057qib7 309 10 at at IN cord-005453-4057qib7 309 11 transplant transplant NN cord-005453-4057qib7 309 12 ( ( -LRB- cord-005453-4057qib7 309 13 1 1 CD cord-005453-4057qib7 309 14 st st NNP cord-005453-4057qib7 309 15 complete complete JJ cord-005453-4057qib7 309 16 remission remission NN cord-005453-4057qib7 309 17 in in IN cord-005453-4057qib7 309 18 68 68 CD cord-005453-4057qib7 309 19 % % NN cord-005453-4057qib7 309 20 versus versus IN cord-005453-4057qib7 309 21 49 49 CD cord-005453-4057qib7 309 22 % % NN cord-005453-4057qib7 309 23 of of IN cord-005453-4057qib7 309 24 MA MA NNP cord-005453-4057qib7 309 25 conditioned condition VBN cord-005453-4057qib7 309 26 patients patient NNS cord-005453-4057qib7 309 27 ) ) -RRB- cord-005453-4057qib7 309 28 and and CC cord-005453-4057qib7 309 29 a a DT cord-005453-4057qib7 309 30 lower low JJR cord-005453-4057qib7 309 31 AML AML NNP cord-005453-4057qib7 309 32 cytogenetic cytogenetic JJ cord-005453-4057qib7 309 33 risk risk NN cord-005453-4057qib7 309 34 ( ( -LRB- cord-005453-4057qib7 309 35 adverse adverse JJ cord-005453-4057qib7 309 36 risk risk NN cord-005453-4057qib7 309 37 in in IN cord-005453-4057qib7 309 38 17 17 CD cord-005453-4057qib7 309 39 % % NN cord-005453-4057qib7 309 40 versus versus IN cord-005453-4057qib7 309 41 21 21 CD cord-005453-4057qib7 309 42 % % NN cord-005453-4057qib7 309 43 of of IN cord-005453-4057qib7 309 44 MA MA NNP cord-005453-4057qib7 309 45 conditioned condition VBN cord-005453-4057qib7 309 46 patients patient NNS cord-005453-4057qib7 309 47 ) ) -RRB- cord-005453-4057qib7 309 48 . . . cord-005453-4057qib7 310 1 Patients patient NNS cord-005453-4057qib7 310 2 were be VBD cord-005453-4057qib7 310 3 followed follow VBN cord-005453-4057qib7 310 4 for for IN cord-005453-4057qib7 310 5 a a DT cord-005453-4057qib7 310 6 total total NN cord-005453-4057qib7 310 7 of of IN cord-005453-4057qib7 310 8 2090 2090 CD cord-005453-4057qib7 310 9 person person NN cord-005453-4057qib7 310 10 - - HYPH cord-005453-4057qib7 310 11 years year NNS cord-005453-4057qib7 310 12 ( ( -LRB- cord-005453-4057qib7 310 13 median median JJ cord-005453-4057qib7 310 14 follow follow NN cord-005453-4057qib7 310 15 - - HYPH cord-005453-4057qib7 310 16 up up NN cord-005453-4057qib7 310 17 in in IN cord-005453-4057qib7 310 18 surviving survive VBG cord-005453-4057qib7 310 19 patients patient NNS cord-005453-4057qib7 310 20 was be VBD cord-005453-4057qib7 310 21 6.2 6.2 CD cord-005453-4057qib7 310 22 years year NNS cord-005453-4057qib7 310 23 ) ) -RRB- cord-005453-4057qib7 310 24 . . . cord-005453-4057qib7 311 1 aGVHD aGVHD NNP cord-005453-4057qib7 311 2 grade grade NNP cord-005453-4057qib7 311 3 II II NNP cord-005453-4057qib7 311 4 - - HYPH cord-005453-4057qib7 311 5 IV IV NNP cord-005453-4057qib7 311 6 occurred occur VBD cord-005453-4057qib7 311 7 less less RBR cord-005453-4057qib7 311 8 frequently frequently RB cord-005453-4057qib7 311 9 in in IN cord-005453-4057qib7 311 10 NMA NMA NNP cord-005453-4057qib7 311 11 conditioned condition VBD cord-005453-4057qib7 311 12 patients patient NNS cord-005453-4057qib7 311 13 ( ( -LRB- cord-005453-4057qib7 311 14 20 20 CD cord-005453-4057qib7 311 15 % % NN cord-005453-4057qib7 311 16 [ [ -LRB- cord-005453-4057qib7 311 17 CI CI NNP cord-005453-4057qib7 311 18 : : : cord-005453-4057qib7 311 19 15%-26 15%-26 CD cord-005453-4057qib7 311 20 % % NN cord-005453-4057qib7 311 21 ] ] -RRB- cord-005453-4057qib7 311 22 versus versus IN cord-005453-4057qib7 311 23 38 38 CD cord-005453-4057qib7 311 24 % % NN cord-005453-4057qib7 311 25 [ [ -LRB- cord-005453-4057qib7 311 26 CI CI NNP cord-005453-4057qib7 311 27 : : : cord-005453-4057qib7 311 28 32%-45 32%-45 CD cord-005453-4057qib7 311 29 % % NN cord-005453-4057qib7 311 30 ] ] -RRB- cord-005453-4057qib7 311 31 in in IN cord-005453-4057qib7 311 32 MA MA NNP cord-005453-4057qib7 311 33 conditioned condition VBD cord-005453-4057qib7 311 34 patients patient NNS cord-005453-4057qib7 311 35 , , , cord-005453-4057qib7 312 1 p p NN cord-005453-4057qib7 312 2 < < NNP cord-005453-4057qib7 312 3 0.01 0.01 CD cord-005453-4057qib7 312 4 ) ) -RRB- cord-005453-4057qib7 312 5 , , , cord-005453-4057qib7 312 6 while while IN cord-005453-4057qib7 312 7 cGVHD cGVHD NNP cord-005453-4057qib7 312 8 occurred occur VBD cord-005453-4057qib7 312 9 in in IN cord-005453-4057qib7 312 10 similar similar JJ cord-005453-4057qib7 312 11 rates rate NNS cord-005453-4057qib7 312 12 ( ( -LRB- cord-005453-4057qib7 312 13 50 50 CD cord-005453-4057qib7 312 14 % % NN cord-005453-4057qib7 312 15 [ [ -LRB- cord-005453-4057qib7 312 16 CI CI NNP cord-005453-4057qib7 312 17 : : : cord-005453-4057qib7 312 18 43%-56 43%-56 CD cord-005453-4057qib7 312 19 % % NN cord-005453-4057qib7 312 20 ] ] -RRB- cord-005453-4057qib7 312 21 in in IN cord-005453-4057qib7 312 22 NMA NMA NNP cord-005453-4057qib7 312 23 conditioned condition VBD cord-005453-4057qib7 312 24 patients patient NNS cord-005453-4057qib7 312 25 and and CC cord-005453-4057qib7 312 26 51 51 CD cord-005453-4057qib7 312 27 % % NN cord-005453-4057qib7 312 28 [ [ -LRB- cord-005453-4057qib7 312 29 CI CI NNP cord-005453-4057qib7 312 30 : : : cord-005453-4057qib7 312 31 44%-58 44%-58 CD cord-005453-4057qib7 312 32 % % NN cord-005453-4057qib7 312 33 ] ] -RRB- cord-005453-4057qib7 312 34 in in IN cord-005453-4057qib7 312 35 MA MA NNP cord-005453-4057qib7 312 36 conditioned condition VBD cord-005453-4057qib7 312 37 patients patient NNS cord-005453-4057qib7 312 38 , , , cord-005453-4057qib7 312 39 p p NN cord-005453-4057qib7 312 40 = = SYM cord-005453-4057qib7 312 41 0.77 0.77 CD cord-005453-4057qib7 312 42 ) ) -RRB- cord-005453-4057qib7 312 43 . . . cord-005453-4057qib7 313 1 There there EX cord-005453-4057qib7 313 2 was be VBD cord-005453-4057qib7 313 3 a a DT cord-005453-4057qib7 313 4 trend trend NN cord-005453-4057qib7 313 5 towards towards IN cord-005453-4057qib7 313 6 a a DT cord-005453-4057qib7 313 7 higher high JJR cord-005453-4057qib7 313 8 relapse relapse NN cord-005453-4057qib7 313 9 rate rate NN cord-005453-4057qib7 313 10 in in IN cord-005453-4057qib7 313 11 NMA NMA NNP cord-005453-4057qib7 313 12 conditioned condition VBD cord-005453-4057qib7 313 13 patients patient NNS cord-005453-4057qib7 313 14 ( ( -LRB- cord-005453-4057qib7 313 15 34 34 CD cord-005453-4057qib7 313 16 % % NN cord-005453-4057qib7 313 17 [ [ -LRB- cord-005453-4057qib7 313 18 CI CI NNP cord-005453-4057qib7 313 19 : : : cord-005453-4057qib7 313 20 28%-40 28%-40 CD cord-005453-4057qib7 313 21 % % NN cord-005453-4057qib7 313 22 ] ] -RRB- cord-005453-4057qib7 313 23 versus versus IN cord-005453-4057qib7 313 24 28 28 CD cord-005453-4057qib7 313 25 % % NN cord-005453-4057qib7 313 26 [ [ -LRB- cord-005453-4057qib7 313 27 CI CI NNP cord-005453-4057qib7 313 28 : : : cord-005453-4057qib7 313 29 22%-34 22%-34 CD cord-005453-4057qib7 313 30 % % NN cord-005453-4057qib7 313 31 ] ] -RRB- cord-005453-4057qib7 313 32 in in IN cord-005453-4057qib7 313 33 MA MA NNP cord-005453-4057qib7 313 34 conditioned condition VBD cord-005453-4057qib7 313 35 patients patient NNS cord-005453-4057qib7 313 36 , , , cord-005453-4057qib7 313 37 p p NN cord-005453-4057qib7 313 38 = = SYM cord-005453-4057qib7 313 39 0.07 0.07 CD cord-005453-4057qib7 313 40 ) ) -RRB- cord-005453-4057qib7 313 41 , , , cord-005453-4057qib7 313 42 and and CC cord-005453-4057qib7 313 43 NMA NMA NNP cord-005453-4057qib7 313 44 conditioned condition VBD cord-005453-4057qib7 313 45 patients patient NNS cord-005453-4057qib7 313 46 had have VBD cord-005453-4057qib7 313 47 , , , cord-005453-4057qib7 313 48 however however RB cord-005453-4057qib7 313 49 not not RB cord-005453-4057qib7 313 50 with with IN cord-005453-4057qib7 313 51 statistical statistical JJ cord-005453-4057qib7 313 52 significance significance NN cord-005453-4057qib7 313 53 , , , cord-005453-4057qib7 313 54 lower low JJR cord-005453-4057qib7 313 55 NRM NRM NNP cord-005453-4057qib7 313 56 ( ( -LRB- cord-005453-4057qib7 313 57 20 20 CD cord-005453-4057qib7 313 58 % % NN cord-005453-4057qib7 313 59 [ [ -LRB- cord-005453-4057qib7 313 60 CI CI NNP cord-005453-4057qib7 313 61 : : : cord-005453-4057qib7 313 62 14%-25 14%-25 CD cord-005453-4057qib7 313 63 % % NN cord-005453-4057qib7 313 64 ] ] -RRB- cord-005453-4057qib7 314 1 versus versus IN cord-005453-4057qib7 314 2 25 25 CD cord-005453-4057qib7 314 3 % % NN cord-005453-4057qib7 314 4 in in IN cord-005453-4057qib7 314 5 MA MA NNP cord-005453-4057qib7 314 6 conditioned condition VBN cord-005453-4057qib7 314 7 patients patient NNS cord-005453-4057qib7 314 8 , , , cord-005453-4057qib7 314 9 p p NN cord-005453-4057qib7 314 10 = = SYM cord-005453-4057qib7 314 11 0.27 0.27 CD cord-005453-4057qib7 314 12 ) ) -RRB- cord-005453-4057qib7 314 13 . . . cord-005453-4057qib7 315 1 OS OS NNP cord-005453-4057qib7 315 2 ( ( -LRB- cord-005453-4057qib7 315 3 Figure figure NN cord-005453-4057qib7 315 4 ) ) -RRB- cord-005453-4057qib7 315 5 was be VBD cord-005453-4057qib7 315 6 comparable comparable JJ cord-005453-4057qib7 315 7 , , , cord-005453-4057qib7 315 8 with with IN cord-005453-4057qib7 315 9 5-year 5-year CD cord-005453-4057qib7 315 10 OS OS NNP cord-005453-4057qib7 315 11 rates rate NNS cord-005453-4057qib7 315 12 of of IN cord-005453-4057qib7 315 13 55 55 CD cord-005453-4057qib7 315 14 % % NN cord-005453-4057qib7 315 15 ( ( -LRB- cord-005453-4057qib7 315 16 CI ci NN cord-005453-4057qib7 315 17 : : : cord-005453-4057qib7 315 18 48%-62 48%-62 CD cord-005453-4057qib7 315 19 % % NN cord-005453-4057qib7 315 20 ) ) -RRB- cord-005453-4057qib7 315 21 in in IN cord-005453-4057qib7 315 22 NMA NMA NNP cord-005453-4057qib7 315 23 conditioned condition VBD cord-005453-4057qib7 315 24 patients patient NNS cord-005453-4057qib7 315 25 and and CC cord-005453-4057qib7 315 26 54 54 CD cord-005453-4057qib7 315 27 % % NN cord-005453-4057qib7 316 1 ( ( -LRB- cord-005453-4057qib7 316 2 CI CI NNP cord-005453-4057qib7 316 3 : : : cord-005453-4057qib7 316 4 47%-61 47%-61 CD cord-005453-4057qib7 316 5 % % NN cord-005453-4057qib7 316 6 ) ) -RRB- cord-005453-4057qib7 316 7 in in IN cord-005453-4057qib7 316 8 MA MA NNP cord-005453-4057qib7 316 9 conditioned condition VBD cord-005453-4057qib7 316 10 patients patient NNS cord-005453-4057qib7 316 11 . . . cord-005453-4057qib7 317 1 Conclusions conclusion NNS cord-005453-4057qib7 317 2 : : : cord-005453-4057qib7 318 1 Patients patient NNS cord-005453-4057qib7 318 2 with with IN cord-005453-4057qib7 318 3 AML AML NNP cord-005453-4057qib7 318 4 undergoing undergo VBG cord-005453-4057qib7 318 5 allo allo NN cord-005453-4057qib7 318 6 - - HYPH cord-005453-4057qib7 318 7 HSCT HSCT NNP cord-005453-4057qib7 318 8 with with IN cord-005453-4057qib7 318 9 NMA NMA NNP cord-005453-4057qib7 318 10 conditioning conditioning NN cord-005453-4057qib7 318 11 at at IN cord-005453-4057qib7 318 12 our -PRON- PRP$ cord-005453-4057qib7 318 13 institution institution NN cord-005453-4057qib7 318 14 were be VBD cord-005453-4057qib7 318 15 older old JJR cord-005453-4057qib7 318 16 and and CC cord-005453-4057qib7 318 17 frailer frail JJR cord-005453-4057qib7 318 18 than than IN cord-005453-4057qib7 318 19 MA MA NNP cord-005453-4057qib7 318 20 conditioned condition VBD cord-005453-4057qib7 318 21 patients patient NNS cord-005453-4057qib7 318 22 , , , cord-005453-4057qib7 318 23 but but CC cord-005453-4057qib7 318 24 their -PRON- PRP$ cord-005453-4057qib7 318 25 overall overall JJ cord-005453-4057qib7 318 26 survival survival NN cord-005453-4057qib7 318 27 after after IN cord-005453-4057qib7 318 28 transplantation transplantation NN cord-005453-4057qib7 318 29 was be VBD cord-005453-4057qib7 318 30 comparable comparable JJ cord-005453-4057qib7 318 31 . . . cord-005453-4057qib7 319 1 This this DT cord-005453-4057qib7 319 2 might may MD cord-005453-4057qib7 319 3 be be VB cord-005453-4057qib7 319 4 explained explain VBN cord-005453-4057qib7 319 5 by by IN cord-005453-4057qib7 319 6 a a DT cord-005453-4057qib7 319 7 generally generally RB cord-005453-4057qib7 319 8 lower low JJR cord-005453-4057qib7 319 9 AML AML NNP cord-005453-4057qib7 319 10 stage stage NN cord-005453-4057qib7 319 11 and and CC cord-005453-4057qib7 319 12 cytogenetic cytogenetic JJ cord-005453-4057qib7 319 13 risk risk NN cord-005453-4057qib7 319 14 at at IN cord-005453-4057qib7 319 15 transplant transplant NN cord-005453-4057qib7 319 16 in in IN cord-005453-4057qib7 319 17 NMA NMA NNP cord-005453-4057qib7 319 18 conditioned condition VBD cord-005453-4057qib7 319 19 patients patient NNS cord-005453-4057qib7 319 20 . . . cord-005453-4057qib7 320 1 Jedlickova jedlickova RB cord-005453-4057qib7 320 2 1 1 CD cord-005453-4057qib7 320 3 , , , cord-005453-4057qib7 320 4 Saskia Saskia NNP cord-005453-4057qib7 320 5 Güller Güller NNP cord-005453-4057qib7 320 6 1 1 CD cord-005453-4057qib7 320 7 , , , cord-005453-4057qib7 320 8 Rosa Rosa NNP cord-005453-4057qib7 320 9 Toenges Toenges NNP cord-005453-4057qib7 320 10 1 1 CD cord-005453-4057qib7 320 11 , , , cord-005453-4057qib7 320 12 Juliane Juliane NNP cord-005453-4057qib7 320 13 Steinmann Steinmann NNP cord-005453-4057qib7 320 14 1 1 CD cord-005453-4057qib7 320 15 , , , cord-005453-4057qib7 320 16 Hans Hans NNP cord-005453-4057qib7 320 17 Martin Martin NNP cord-005453-4057qib7 320 18 1 1 CD cord-005453-4057qib7 320 19 , , , cord-005453-4057qib7 320 20 Hubert Hubert NNP cord-005453-4057qib7 320 21 Serve Serve NNP cord-005453-4057qib7 320 22 1 1 CD cord-005453-4057qib7 320 23 , , , cord-005453-4057qib7 320 24 Gesine Gesine NNP cord-005453-4057qib7 320 25 Bug bug NN cord-005453-4057qib7 320 26 1 1 CD cord-005453-4057qib7 320 27 Background Background NNP cord-005453-4057qib7 320 28 : : : cord-005453-4057qib7 321 1 Allogeneic Allogeneic NNP cord-005453-4057qib7 321 2 HSCT HSCT NNP cord-005453-4057qib7 321 3 is be VBZ cord-005453-4057qib7 321 4 urgently urgently RB cord-005453-4057qib7 321 5 indicated indicate VBN cord-005453-4057qib7 321 6 in in IN cord-005453-4057qib7 321 7 patients patient NNS cord-005453-4057qib7 321 8 with with IN cord-005453-4057qib7 321 9 AML AML NNP cord-005453-4057qib7 321 10 in in IN cord-005453-4057qib7 321 11 first first JJ cord-005453-4057qib7 321 12 complete complete JJ cord-005453-4057qib7 321 13 hematologic hematologic JJ cord-005453-4057qib7 321 14 remission remission NN cord-005453-4057qib7 321 15 ( ( -LRB- cord-005453-4057qib7 321 16 CHR CHR NNP cord-005453-4057qib7 321 17 ) ) -RRB- cord-005453-4057qib7 321 18 after after IN cord-005453-4057qib7 321 19 intensive intensive JJ cord-005453-4057qib7 321 20 chemotherapy chemotherapy NN cord-005453-4057qib7 321 21 with with IN cord-005453-4057qib7 321 22 increasing increase VBG cord-005453-4057qib7 321 23 or or CC cord-005453-4057qib7 321 24 recurrent recurrent JJ cord-005453-4057qib7 321 25 minimal minimal JJ cord-005453-4057qib7 321 26 residual residual JJ cord-005453-4057qib7 321 27 disease disease NN cord-005453-4057qib7 321 28 ( ( -LRB- cord-005453-4057qib7 321 29 MRD MRD NNP cord-005453-4057qib7 321 30 ) ) -RRB- cord-005453-4057qib7 321 31 . . . cord-005453-4057qib7 322 1 These these DT cord-005453-4057qib7 322 2 patients patient NNS cord-005453-4057qib7 322 3 are be VBP cord-005453-4057qib7 322 4 at at IN cord-005453-4057qib7 322 5 high high JJ cord-005453-4057qib7 322 6 risk risk NN cord-005453-4057qib7 322 7 of of IN cord-005453-4057qib7 322 8 hematologic hematologic JJ cord-005453-4057qib7 322 9 relapse relapse NN cord-005453-4057qib7 322 10 ( ( -LRB- cord-005453-4057qib7 322 11 HR HR NNP cord-005453-4057qib7 322 12 ) ) -RRB- cord-005453-4057qib7 322 13 during during IN cord-005453-4057qib7 322 14 preparation preparation NN cord-005453-4057qib7 322 15 of of IN cord-005453-4057qib7 322 16 their -PRON- PRP$ cord-005453-4057qib7 322 17 transplant transplant NN cord-005453-4057qib7 322 18 and and CC cord-005453-4057qib7 322 19 HSCT HSCT NNP cord-005453-4057qib7 322 20 with with IN cord-005453-4057qib7 322 21 active active JJ cord-005453-4057qib7 322 22 AML AML NNP cord-005453-4057qib7 322 23 was be VBD cord-005453-4057qib7 322 24 found find VBN cord-005453-4057qib7 322 25 associated associate VBN cord-005453-4057qib7 322 26 with with IN cord-005453-4057qib7 322 27 poor poor JJ cord-005453-4057qib7 322 28 outcome outcome NN cord-005453-4057qib7 322 29 . . . cord-005453-4057qib7 323 1 Azacitidine Azacitidine NNP cord-005453-4057qib7 323 2 has have VBZ cord-005453-4057qib7 323 3 recently recently RB cord-005453-4057qib7 323 4 been be VBN cord-005453-4057qib7 323 5 shown show VBN cord-005453-4057qib7 323 6 to to TO cord-005453-4057qib7 323 7 substantially substantially RB cord-005453-4057qib7 323 8 delay delay VB cord-005453-4057qib7 323 9 or or CC cord-005453-4057qib7 323 10 even even RB cord-005453-4057qib7 323 11 prevent prevent VB cord-005453-4057qib7 323 12 HR hr NN cord-005453-4057qib7 323 13 in in IN cord-005453-4057qib7 323 14 > > $ cord-005453-4057qib7 323 15 50 50 CD cord-005453-4057qib7 323 16 % % NN cord-005453-4057qib7 323 17 of of IN cord-005453-4057qib7 323 18 patients patient NNS cord-005453-4057qib7 323 19 ( ( -LRB- cord-005453-4057qib7 323 20 RELAZA2 RELAZA2 NNS cord-005453-4057qib7 323 21 trial trial NN cord-005453-4057qib7 323 22 , , , cord-005453-4057qib7 323 23 Platzbecker Platzbecker NNP cord-005453-4057qib7 323 24 et et NNP cord-005453-4057qib7 323 25 al al NNP cord-005453-4057qib7 323 26 . . . cord-005453-4057qib7 324 1 , , , cord-005453-4057qib7 324 2 Lancet Lancet NNP cord-005453-4057qib7 324 3 Oncology Oncology NNP cord-005453-4057qib7 324 4 2018 2018 CD cord-005453-4057qib7 324 5 ) ) -RRB- cord-005453-4057qib7 324 6 . . . cord-005453-4057qib7 325 1 We -PRON- PRP cord-005453-4057qib7 325 2 here here RB cord-005453-4057qib7 325 3 present present VBP cord-005453-4057qib7 325 4 the the DT cord-005453-4057qib7 325 5 outcome outcome NN cord-005453-4057qib7 325 6 of of IN cord-005453-4057qib7 325 7 a a DT cord-005453-4057qib7 325 8 small small JJ cord-005453-4057qib7 325 9 cohort cohort NN cord-005453-4057qib7 325 10 of of IN cord-005453-4057qib7 325 11 consecutive consecutive JJ cord-005453-4057qib7 325 12 patients patient NNS cord-005453-4057qib7 325 13 with with IN cord-005453-4057qib7 325 14 MRD MRD NNP cord-005453-4057qib7 325 15 - - HYPH cord-005453-4057qib7 325 16 positive positive JJ cord-005453-4057qib7 325 17 AML AML NNP cord-005453-4057qib7 325 18 who who WP cord-005453-4057qib7 325 19 received receive VBD cord-005453-4057qib7 325 20 low low JJ cord-005453-4057qib7 325 21 dose dose NN cord-005453-4057qib7 325 22 cytarabine cytarabine NN cord-005453-4057qib7 325 23 ( ( -LRB- cord-005453-4057qib7 325 24 LDARAC LDARAC NNP cord-005453-4057qib7 325 25 ) ) -RRB- cord-005453-4057qib7 325 26 as as IN cord-005453-4057qib7 325 27 bridging bridge VBG cord-005453-4057qib7 325 28 therapy therapy NN cord-005453-4057qib7 325 29 prior prior RB cord-005453-4057qib7 325 30 to to IN cord-005453-4057qib7 325 31 HSCT HSCT NNP cord-005453-4057qib7 325 32 . . . cord-005453-4057qib7 326 1 Methods method NNS cord-005453-4057qib7 326 2 : : : cord-005453-4057qib7 327 1 MRD MRD NNP cord-005453-4057qib7 327 2 was be VBD cord-005453-4057qib7 327 3 assessed assess VBN cord-005453-4057qib7 327 4 by by IN cord-005453-4057qib7 327 5 quantitative quantitative JJ cord-005453-4057qib7 327 6 polymerase polymerase NN cord-005453-4057qib7 327 7 chain chain NN cord-005453-4057qib7 327 8 reaction reaction NN cord-005453-4057qib7 327 9 ( ( -LRB- cord-005453-4057qib7 327 10 qPCR qPCR NNP cord-005453-4057qib7 327 11 ) ) -RRB- cord-005453-4057qib7 327 12 using use VBG cord-005453-4057qib7 327 13 mutated mutate VBN cord-005453-4057qib7 327 14 NPM1 NPM1 NNP cord-005453-4057qib7 327 15 ( ( -LRB- cord-005453-4057qib7 327 16 n=5 n=5 NNP cord-005453-4057qib7 327 17 ) ) -RRB- cord-005453-4057qib7 327 18 , , , cord-005453-4057qib7 327 19 RUNX1-RUNX1T1 runx1-runx1t1 NN cord-005453-4057qib7 327 20 ( ( -LRB- cord-005453-4057qib7 327 21 n=2 n=2 NNS cord-005453-4057qib7 327 22 ) ) -RRB- cord-005453-4057qib7 327 23 , , , cord-005453-4057qib7 327 24 CBFB CBFB NNP cord-005453-4057qib7 327 25 - - HYPH cord-005453-4057qib7 327 26 MYH11 MYH11 NNP cord-005453-4057qib7 327 27 ( ( -LRB- cord-005453-4057qib7 327 28 n=1 n=1 NNP cord-005453-4057qib7 327 29 ) ) -RRB- cord-005453-4057qib7 327 30 or or CC cord-005453-4057qib7 327 31 KMT2A KMT2A NNP cord-005453-4057qib7 327 32 - - HYPH cord-005453-4057qib7 327 33 PTD PTD NNP cord-005453-4057qib7 327 34 ( ( -LRB- cord-005453-4057qib7 327 35 n=1 n=1 NN cord-005453-4057qib7 327 36 ) ) -RRB- cord-005453-4057qib7 327 37 . . . cord-005453-4057qib7 328 1 MRD MRD NNP cord-005453-4057qib7 328 2 negativity negativity NN cord-005453-4057qib7 328 3 was be VBD cord-005453-4057qib7 328 4 defined define VBN cord-005453-4057qib7 328 5 as as IN cord-005453-4057qib7 328 6 ratio ratio NN cord-005453-4057qib7 328 7 of of IN cord-005453-4057qib7 328 8 oncogene oncogene NN cord-005453-4057qib7 328 9 to to TO cord-005453-4057qib7 328 10 control control VB cord-005453-4057qib7 328 11 gene gene NN cord-005453-4057qib7 328 12 ( ( -LRB- cord-005453-4057qib7 328 13 ABL1 ABL1 NNP cord-005453-4057qib7 328 14 ) ) -RRB- cord-005453-4057qib7 329 1 ≤0,01 ≤0,01 NNP cord-005453-4057qib7 329 2 % % NN cord-005453-4057qib7 330 1 while while IN cord-005453-4057qib7 330 2 increased increase VBN cord-005453-4057qib7 330 3 or or CC cord-005453-4057qib7 330 4 recurrent recurrent JJ cord-005453-4057qib7 330 5 MRD MRD NNP cord-005453-4057qib7 330 6 required require VBD cord-005453-4057qib7 330 7 a a DT cord-005453-4057qib7 330 8 ratio ratio NN cord-005453-4057qib7 330 9 > > XX cord-005453-4057qib7 330 10 1 1 CD cord-005453-4057qib7 330 11 % % NN cord-005453-4057qib7 331 1 ( ( -LRB- cord-005453-4057qib7 331 2 Shayegi Shayegi NNP cord-005453-4057qib7 331 3 et et NNP cord-005453-4057qib7 331 4 al al NNP cord-005453-4057qib7 331 5 . . NNP cord-005453-4057qib7 331 6 , , , cord-005453-4057qib7 331 7 Blood blood NN cord-005453-4057qib7 331 8 2013 2013 CD cord-005453-4057qib7 331 9 ) ) -RRB- cord-005453-4057qib7 331 10 . . . cord-005453-4057qib7 332 1 Primary primary JJ cord-005453-4057qib7 332 2 endpoint endpoint NN cord-005453-4057qib7 332 3 of of IN cord-005453-4057qib7 332 4 our -PRON- PRP$ cord-005453-4057qib7 332 5 retrospective retrospective JJ cord-005453-4057qib7 332 6 analysis analysis NN cord-005453-4057qib7 332 7 was be VBD cord-005453-4057qib7 332 8 progression progression NN cord-005453-4057qib7 332 9 to to IN cord-005453-4057qib7 332 10 HR HR NNP cord-005453-4057qib7 332 11 ( ( -LRB- cord-005453-4057qib7 332 12 ≥5 ≥5 NNP cord-005453-4057qib7 332 13 % % NN cord-005453-4057qib7 332 14 bone bone NN cord-005453-4057qib7 332 15 marrow marrow NN cord-005453-4057qib7 332 16 blasts blast NNS cord-005453-4057qib7 332 17 or or CC cord-005453-4057qib7 332 18 extramedullary extramedullary JJ cord-005453-4057qib7 332 19 disease disease NN cord-005453-4057qib7 332 20 ) ) -RRB- cord-005453-4057qib7 332 21 ; ; , cord-005453-4057qib7 332 22 secondary secondary JJ cord-005453-4057qib7 332 23 endpoints endpoint NNS cord-005453-4057qib7 332 24 were be VBD cord-005453-4057qib7 332 25 achievement achievement NN cord-005453-4057qib7 332 26 of of IN cord-005453-4057qib7 332 27 molecular molecular JJ cord-005453-4057qib7 332 28 remission remission NN cord-005453-4057qib7 332 29 prior prior RB cord-005453-4057qib7 332 30 to to IN cord-005453-4057qib7 332 31 HSCT HSCT NNP cord-005453-4057qib7 332 32 , , , cord-005453-4057qib7 333 1 neutropenia neutropenia NNP cord-005453-4057qib7 333 2 G4 G4 NNP cord-005453-4057qib7 333 3 according accord VBG cord-005453-4057qib7 333 4 to to IN cord-005453-4057qib7 333 5 CTCAE CTCAE NNP cord-005453-4057qib7 333 6 , , , cord-005453-4057qib7 333 7 thrombocytopenia thrombocytopenia VBD cord-005453-4057qib7 333 8 G4 G4 NNP cord-005453-4057qib7 333 9 , , , cord-005453-4057qib7 333 10 anemia anemia NN cord-005453-4057qib7 333 11 ≥G3 ≥G3 NNP cord-005453-4057qib7 333 12 , , , cord-005453-4057qib7 333 13 admission admission NN cord-005453-4057qib7 333 14 to to IN cord-005453-4057qib7 333 15 hospital hospital NN cord-005453-4057qib7 333 16 , , , cord-005453-4057qib7 333 17 OS OS NNP cord-005453-4057qib7 333 18 and and CC cord-005453-4057qib7 333 19 RFS RFS NNP cord-005453-4057qib7 333 20 . . . cord-005453-4057qib7 334 1 OS OS NNP cord-005453-4057qib7 334 2 and and CC cord-005453-4057qib7 334 3 RFS RFS NNP cord-005453-4057qib7 334 4 were be VBD cord-005453-4057qib7 334 5 calculated calculate VBN cord-005453-4057qib7 334 6 from from IN cord-005453-4057qib7 334 7 the the DT cord-005453-4057qib7 334 8 first first JJ cord-005453-4057qib7 334 9 dose dose NN cord-005453-4057qib7 334 10 of of IN cord-005453-4057qib7 334 11 LDARAC LDARAC NNP cord-005453-4057qib7 334 12 . . . cord-005453-4057qib7 335 1 LDARAC LDARAC NNP cord-005453-4057qib7 335 2 was be VBD cord-005453-4057qib7 335 3 self self NN cord-005453-4057qib7 335 4 - - HYPH cord-005453-4057qib7 335 5 administered administer VBN cord-005453-4057qib7 335 6 subcutaneously subcutaneously RB cord-005453-4057qib7 335 7 by by IN cord-005453-4057qib7 335 8 the the DT cord-005453-4057qib7 335 9 patients patient NNS cord-005453-4057qib7 335 10 at at IN cord-005453-4057qib7 335 11 home home NN cord-005453-4057qib7 335 12 at at IN cord-005453-4057qib7 335 13 a a DT cord-005453-4057qib7 335 14 flat flat JJ cord-005453-4057qib7 335 15 dose dose NN cord-005453-4057qib7 335 16 of of IN cord-005453-4057qib7 335 17 20 20 CD cord-005453-4057qib7 335 18 mg mg NNP cord-005453-4057qib7 335 19 BID BID VBN cord-005453-4057qib7 335 20 over over IN cord-005453-4057qib7 335 21 10 10 CD cord-005453-4057qib7 335 22 days day NNS cord-005453-4057qib7 335 23 and and CC cord-005453-4057qib7 335 24 repeated repeat VBN cord-005453-4057qib7 335 25 after after IN cord-005453-4057qib7 335 26 4 4 CD cord-005453-4057qib7 335 27 weeks week NNS cord-005453-4057qib7 335 28 if if IN cord-005453-4057qib7 335 29 necessary necessary JJ cord-005453-4057qib7 335 30 . . . cord-005453-4057qib7 336 1 Results result NNS cord-005453-4057qib7 336 2 : : : cord-005453-4057qib7 337 1 Between between IN cord-005453-4057qib7 337 2 12/2015 12/2015 CD cord-005453-4057qib7 337 3 and and CC cord-005453-4057qib7 337 4 10/2018 10/2018 CD cord-005453-4057qib7 337 5 , , , cord-005453-4057qib7 337 6 nine nine CD cord-005453-4057qib7 337 7 patients patient NNS cord-005453-4057qib7 337 8 ( ( -LRB- cord-005453-4057qib7 337 9 median median JJ cord-005453-4057qib7 337 10 age age NN cord-005453-4057qib7 337 11 55 55 CD cord-005453-4057qib7 337 12 , , , cord-005453-4057qib7 337 13 range range NN cord-005453-4057qib7 337 14 , , , cord-005453-4057qib7 337 15 22 22 CD cord-005453-4057qib7 337 16 - - SYM cord-005453-4057qib7 337 17 68 68 CD cord-005453-4057qib7 337 18 years year NNS cord-005453-4057qib7 337 19 ) ) -RRB- cord-005453-4057qib7 337 20 with with IN cord-005453-4057qib7 337 21 low low JJ cord-005453-4057qib7 337 22 ( ( -LRB- cord-005453-4057qib7 337 23 n=7 n=7 NNS cord-005453-4057qib7 337 24 ) ) -RRB- cord-005453-4057qib7 337 25 , , , cord-005453-4057qib7 337 26 intermediate intermediate JJ cord-005453-4057qib7 337 27 ( ( -LRB- cord-005453-4057qib7 337 28 n=1 n=1 JJ cord-005453-4057qib7 337 29 ) ) -RRB- cord-005453-4057qib7 337 30 or or CC cord-005453-4057qib7 337 31 high high JJ cord-005453-4057qib7 337 32 - - HYPH cord-005453-4057qib7 337 33 risk risk NN cord-005453-4057qib7 337 34 cytogenetics cytogenetic NNS cord-005453-4057qib7 337 35 ( ( -LRB- cord-005453-4057qib7 337 36 n=1 n=1 FW cord-005453-4057qib7 337 37 ) ) -RRB- cord-005453-4057qib7 337 38 according accord VBG cord-005453-4057qib7 337 39 to to IN cord-005453-4057qib7 337 40 ELN ELN NNP cord-005453-4057qib7 337 41 criteria criterion NNS cord-005453-4057qib7 337 42 2017 2017 CD cord-005453-4057qib7 337 43 were be VBD cord-005453-4057qib7 337 44 treated treat VBN cord-005453-4057qib7 337 45 in in IN cord-005453-4057qib7 337 46 continuous continuous JJ cord-005453-4057qib7 337 47 CHR CHR NNP cord-005453-4057qib7 337 48 for for IN cord-005453-4057qib7 337 49 increasing increase VBG cord-005453-4057qib7 337 50 ( ( -LRB- cord-005453-4057qib7 337 51 n=2 n=2 NNS cord-005453-4057qib7 337 52 ) ) -RRB- cord-005453-4057qib7 337 53 or or CC cord-005453-4057qib7 337 54 recurrent recurrent JJ cord-005453-4057qib7 337 55 MRD MRD NNP cord-005453-4057qib7 337 56 ( ( -LRB- cord-005453-4057qib7 337 57 n=7 n=7 NN cord-005453-4057qib7 337 58 ) ) -RRB- cord-005453-4057qib7 337 59 starting start VBG cord-005453-4057qib7 337 60 at at IN cord-005453-4057qib7 337 61 a a DT cord-005453-4057qib7 337 62 median median NN cord-005453-4057qib7 337 63 of of IN cord-005453-4057qib7 337 64 260 260 CD cord-005453-4057qib7 338 1 ( ( -LRB- cord-005453-4057qib7 338 2 range range NN cord-005453-4057qib7 338 3 , , , cord-005453-4057qib7 338 4 154 154 CD cord-005453-4057qib7 338 5 - - SYM cord-005453-4057qib7 338 6 651 651 CD cord-005453-4057qib7 338 7 ) ) -RRB- cord-005453-4057qib7 338 8 days day NNS cord-005453-4057qib7 338 9 after after IN cord-005453-4057qib7 338 10 the the DT cord-005453-4057qib7 338 11 last last JJ cord-005453-4057qib7 338 12 consolidation consolidation NN cord-005453-4057qib7 338 13 therapy therapy NN cord-005453-4057qib7 338 14 , , , cord-005453-4057qib7 338 15 i.e. i.e. FW cord-005453-4057qib7 338 16 , , , cord-005453-4057qib7 338 17 duration duration NN cord-005453-4057qib7 338 18 of of IN cord-005453-4057qib7 338 19 CHR CHR NNP cord-005453-4057qib7 338 20 was be VBD cord-005453-4057qib7 338 21 > > NFP cord-005453-4057qib7 338 22 6 6 CD cord-005453-4057qib7 338 23 months month NNS cord-005453-4057qib7 338 24 in in IN cord-005453-4057qib7 338 25 all all DT cord-005453-4057qib7 338 26 pts pt NNS cord-005453-4057qib7 338 27 . . . cord-005453-4057qib7 339 1 Patients patient NNS cord-005453-4057qib7 339 2 received receive VBD cord-005453-4057qib7 339 3 one one CD cord-005453-4057qib7 339 4 ( ( -LRB- cord-005453-4057qib7 339 5 n=4 n=4 NNS cord-005453-4057qib7 339 6 ) ) -RRB- cord-005453-4057qib7 339 7 , , , cord-005453-4057qib7 339 8 two two CD cord-005453-4057qib7 339 9 ( ( -LRB- cord-005453-4057qib7 339 10 n=2 n=2 NNS cord-005453-4057qib7 339 11 ) ) -RRB- cord-005453-4057qib7 339 12 or or CC cord-005453-4057qib7 339 13 three three CD cord-005453-4057qib7 339 14 cycles cycle NNS cord-005453-4057qib7 339 15 ( ( -LRB- cord-005453-4057qib7 339 16 n=3 n=3 NN cord-005453-4057qib7 339 17 ) ) -RRB- cord-005453-4057qib7 339 18 of of IN cord-005453-4057qib7 339 19 LDARAC LDARAC NNP cord-005453-4057qib7 339 20 prior prior RB cord-005453-4057qib7 339 21 to to IN cord-005453-4057qib7 339 22 HSCT HSCT NNP cord-005453-4057qib7 339 23 . . . cord-005453-4057qib7 340 1 In in IN cord-005453-4057qib7 340 2 three three CD cord-005453-4057qib7 340 3 patients patient NNS cord-005453-4057qib7 340 4 , , , cord-005453-4057qib7 340 5 neutropenia neutropenia NN cord-005453-4057qib7 340 6 G4 G4 NNP cord-005453-4057qib7 340 7 occurred occur VBD cord-005453-4057qib7 340 8 and and CC cord-005453-4057qib7 340 9 one one CD cord-005453-4057qib7 340 10 patient patient NN cord-005453-4057qib7 340 11 needed need VBD cord-005453-4057qib7 340 12 platelet platelet NN cord-005453-4057qib7 340 13 transfusion transfusion NN cord-005453-4057qib7 340 14 . . . cord-005453-4057qib7 341 1 All all DT cord-005453-4057qib7 341 2 patients patient NNS cord-005453-4057qib7 341 3 were be VBD cord-005453-4057qib7 341 4 managed manage VBN cord-005453-4057qib7 341 5 in in IN cord-005453-4057qib7 341 6 the the DT cord-005453-4057qib7 341 7 outpatient outpatient NN cord-005453-4057qib7 341 8 setting setting NN cord-005453-4057qib7 341 9 . . . cord-005453-4057qib7 342 1 In in IN cord-005453-4057qib7 342 2 eight eight CD cord-005453-4057qib7 342 3 out out IN cord-005453-4057qib7 342 4 of of IN cord-005453-4057qib7 342 5 nine nine CD cord-005453-4057qib7 342 6 patients patient NNS cord-005453-4057qib7 342 7 ( ( -LRB- cord-005453-4057qib7 342 8 89 89 CD cord-005453-4057qib7 342 9 % % NN cord-005453-4057qib7 342 10 ) ) -RRB- cord-005453-4057qib7 342 11 , , , cord-005453-4057qib7 342 12 HR HR NNP cord-005453-4057qib7 342 13 was be VBD cord-005453-4057qib7 342 14 successfully successfully RB cord-005453-4057qib7 342 15 prevented prevent VBN cord-005453-4057qib7 342 16 and and CC cord-005453-4057qib7 342 17 3 3 CD cord-005453-4057qib7 342 18 patients patient NNS cord-005453-4057qib7 342 19 ( ( -LRB- cord-005453-4057qib7 342 20 33 33 CD cord-005453-4057qib7 342 21 % % NN cord-005453-4057qib7 342 22 ) ) -RRB- cord-005453-4057qib7 342 23 even even RB cord-005453-4057qib7 342 24 became become VBD cord-005453-4057qib7 342 25 MRD MRD NNP cord-005453-4057qib7 342 26 negative negative JJ cord-005453-4057qib7 342 27 prior prior RB cord-005453-4057qib7 342 28 to to IN cord-005453-4057qib7 342 29 HSCT HSCT NNP cord-005453-4057qib7 342 30 . . . cord-005453-4057qib7 343 1 One one CD cord-005453-4057qib7 343 2 patient patient NN cord-005453-4057qib7 343 3 ( ( -LRB- cord-005453-4057qib7 343 4 RUNX1-RUNX1T1 runx1-runx1t1 CD cord-005453-4057qib7 343 5 positive positive JJ cord-005453-4057qib7 343 6 AML AML NNP cord-005453-4057qib7 343 7 ) ) -RRB- cord-005453-4057qib7 343 8 progressed progress VBD cord-005453-4057qib7 343 9 to to IN cord-005453-4057qib7 343 10 HR hr NN cord-005453-4057qib7 343 11 after after IN cord-005453-4057qib7 343 12 one one CD cord-005453-4057qib7 343 13 cycle cycle NN cord-005453-4057qib7 343 14 of of IN cord-005453-4057qib7 343 15 LDARAC LDARAC NNP cord-005453-4057qib7 343 16 and and CC cord-005453-4057qib7 343 17 received receive VBD cord-005453-4057qib7 343 18 salvage salvage NN cord-005453-4057qib7 343 19 therapy therapy NN cord-005453-4057qib7 343 20 with with IN cord-005453-4057qib7 343 21 high high JJ cord-005453-4057qib7 343 22 - - HYPH cord-005453-4057qib7 343 23 dose dose NN cord-005453-4057qib7 343 24 ARAC ARAC NNP cord-005453-4057qib7 343 25 and and CC cord-005453-4057qib7 343 26 mitoxantrone mitoxantrone NN cord-005453-4057qib7 343 27 ( ( -LRB- cord-005453-4057qib7 343 28 HAM HAM NNP cord-005453-4057qib7 343 29 ) ) -RRB- cord-005453-4057qib7 343 30 prior prior RB cord-005453-4057qib7 343 31 to to IN cord-005453-4057qib7 343 32 HSCT HSCT NNP cord-005453-4057qib7 343 33 . . . cord-005453-4057qib7 344 1 All all DT cord-005453-4057qib7 344 2 patients patient NNS cord-005453-4057qib7 344 3 proceeded proceed VBD cord-005453-4057qib7 344 4 to to IN cord-005453-4057qib7 344 5 HSCT HSCT NNP cord-005453-4057qib7 344 6 from from IN cord-005453-4057qib7 344 7 a a DT cord-005453-4057qib7 344 8 matched match VBN cord-005453-4057qib7 344 9 related relate VBN cord-005453-4057qib7 344 10 ( ( -LRB- cord-005453-4057qib7 344 11 n=1 n=1 CD cord-005453-4057qib7 344 12 ) ) -RRB- cord-005453-4057qib7 344 13 , , , cord-005453-4057qib7 344 14 unrelated unrelated JJ cord-005453-4057qib7 344 15 ( ( -LRB- cord-005453-4057qib7 344 16 n=7 n=7 NNS cord-005453-4057qib7 344 17 ) ) -RRB- cord-005453-4057qib7 344 18 or or CC cord-005453-4057qib7 344 19 haploidentical haploidentical JJ cord-005453-4057qib7 344 20 donor donor NN cord-005453-4057qib7 344 21 ( ( -LRB- cord-005453-4057qib7 344 22 n=1 n=1 FW cord-005453-4057qib7 344 23 ) ) -RRB- cord-005453-4057qib7 344 24 and and CC cord-005453-4057qib7 344 25 are be VBP cord-005453-4057qib7 344 26 still still RB cord-005453-4057qib7 344 27 alive alive JJ cord-005453-4057qib7 344 28 ( ( -LRB- cord-005453-4057qib7 344 29 median median JJ cord-005453-4057qib7 344 30 follow follow NN cord-005453-4057qib7 344 31 - - HYPH cord-005453-4057qib7 344 32 up up NN cord-005453-4057qib7 344 33 of of IN cord-005453-4057qib7 344 34 666 666 CD cord-005453-4057qib7 344 35 days day NNS cord-005453-4057qib7 344 36 ) ) -RRB- cord-005453-4057qib7 344 37 . . . cord-005453-4057qib7 345 1 Conditioning conditioning NN cord-005453-4057qib7 345 2 regimens regimen NNS cord-005453-4057qib7 345 3 included include VBD cord-005453-4057qib7 345 4 fludarabine fludarabine NN cord-005453-4057qib7 345 5 ( ( -LRB- cord-005453-4057qib7 345 6 FLU)/melphalan FLU)/melphalan NNP cord-005453-4057qib7 345 7 ( ( -LRB- cord-005453-4057qib7 345 8 MEL)/TBI MEL)/TBI NNP cord-005453-4057qib7 345 9 ( ( -LRB- cord-005453-4057qib7 345 10 n=5 n=5 NNP cord-005453-4057qib7 345 11 ) ) -RRB- cord-005453-4057qib7 345 12 , , , cord-005453-4057qib7 345 13 FLU FLU NNP cord-005453-4057qib7 345 14 / / SYM cord-005453-4057qib7 345 15 MEL MEL NNP cord-005453-4057qib7 345 16 ( ( -LRB- cord-005453-4057qib7 345 17 n=1 n=1 NNP cord-005453-4057qib7 345 18 ) ) -RRB- cord-005453-4057qib7 345 19 , , , cord-005453-4057qib7 345 20 FLU FLU NNP cord-005453-4057qib7 345 21 / / SYM cord-005453-4057qib7 345 22 TBI TBI NNP cord-005453-4057qib7 345 23 ( ( -LRB- cord-005453-4057qib7 345 24 n=1 n=1 NNP cord-005453-4057qib7 345 25 ) ) -RRB- cord-005453-4057qib7 345 26 , , , cord-005453-4057qib7 345 27 FLU FLU NNP cord-005453-4057qib7 345 28 / / SYM cord-005453-4057qib7 345 29 busulfan busulfan NN cord-005453-4057qib7 346 1 ( ( -LRB- cord-005453-4057qib7 346 2 BU)4 bu)4 NN cord-005453-4057qib7 346 3 ( ( -LRB- cord-005453-4057qib7 346 4 n=1 n=1 NNP cord-005453-4057qib7 346 5 ) ) -RRB- cord-005453-4057qib7 346 6 and and CC cord-005453-4057qib7 346 7 thiotepa thiotepa JJ cord-005453-4057qib7 346 8 / / SYM cord-005453-4057qib7 346 9 BU3 BU3 NNP cord-005453-4057qib7 346 10 / / SYM cord-005453-4057qib7 346 11 FLU FLU NNP cord-005453-4057qib7 346 12 ( ( -LRB- cord-005453-4057qib7 346 13 n=1 n=1 NN cord-005453-4057qib7 346 14 ) ) -RRB- cord-005453-4057qib7 346 15 . . . cord-005453-4057qib7 347 1 After after IN cord-005453-4057qib7 347 2 HSCT HSCT NNP cord-005453-4057qib7 347 3 , , , cord-005453-4057qib7 347 4 only only RB cord-005453-4057qib7 347 5 the the DT cord-005453-4057qib7 347 6 LDARAC ldarac JJ cord-005453-4057qib7 347 7 - - HYPH cord-005453-4057qib7 347 8 refractory refractory JJ cord-005453-4057qib7 347 9 patient patient NN cord-005453-4057qib7 347 10 relapsed relapse VBD cord-005453-4057qib7 347 11 , , , cord-005453-4057qib7 347 12 resulting result VBG cord-005453-4057qib7 347 13 in in IN cord-005453-4057qib7 347 14 a a DT cord-005453-4057qib7 347 15 probability probability NN cord-005453-4057qib7 347 16 of of IN cord-005453-4057qib7 347 17 RFS RFS NNP cord-005453-4057qib7 347 18 of of IN cord-005453-4057qib7 347 19 88 88 CD cord-005453-4057qib7 347 20 % % NN cord-005453-4057qib7 347 21 at at IN cord-005453-4057qib7 347 22 2 2 CD cord-005453-4057qib7 347 23 years year NNS cord-005453-4057qib7 347 24 . . . cord-005453-4057qib7 348 1 Conclusions conclusion NNS cord-005453-4057qib7 348 2 : : : cord-005453-4057qib7 349 1 Our -PRON- PRP$ cord-005453-4057qib7 349 2 data datum NNS cord-005453-4057qib7 349 3 suggest suggest VBP cord-005453-4057qib7 349 4 that that IN cord-005453-4057qib7 349 5 a a DT cord-005453-4057qib7 349 6 bridging bridge VBG cord-005453-4057qib7 349 7 therapy therapy NN cord-005453-4057qib7 349 8 with with IN cord-005453-4057qib7 349 9 up up IN cord-005453-4057qib7 349 10 to to TO cord-005453-4057qib7 349 11 three three CD cord-005453-4057qib7 349 12 cycles cycle NNS cord-005453-4057qib7 349 13 of of IN cord-005453-4057qib7 349 14 LDARAC LDARAC NNP cord-005453-4057qib7 349 15 prior prior RB cord-005453-4057qib7 349 16 to to IN cord-005453-4057qib7 349 17 HSCT HSCT NNP cord-005453-4057qib7 349 18 is be VBZ cord-005453-4057qib7 349 19 feasible feasible JJ cord-005453-4057qib7 349 20 and and CC cord-005453-4057qib7 349 21 was be VBD cord-005453-4057qib7 349 22 associated associate VBN cord-005453-4057qib7 349 23 with with IN cord-005453-4057qib7 349 24 favorable favorable JJ cord-005453-4057qib7 349 25 outcomes outcome NNS cord-005453-4057qib7 349 26 in in IN cord-005453-4057qib7 349 27 patients patient NNS cord-005453-4057qib7 349 28 with with IN cord-005453-4057qib7 349 29 NPM1-mutated npm1-mutated JJ cord-005453-4057qib7 349 30 or or CC cord-005453-4057qib7 349 31 core core NN cord-005453-4057qib7 349 32 binding binding NN cord-005453-4057qib7 349 33 factor factor NN cord-005453-4057qib7 349 34 AML AML NNP cord-005453-4057qib7 349 35 and and CC cord-005453-4057qib7 349 36 molecular molecular JJ cord-005453-4057qib7 349 37 relapse relapse NN cord-005453-4057qib7 349 38 > > XX cord-005453-4057qib7 349 39 6 6 CD cord-005453-4057qib7 349 40 months month NNS cord-005453-4057qib7 349 41 after after IN cord-005453-4057qib7 349 42 achieving achieve VBG cord-005453-4057qib7 349 43 a a DT cord-005453-4057qib7 349 44 first first JJ cord-005453-4057qib7 349 45 CHR CHR NNP cord-005453-4057qib7 349 46 . . . cord-005453-4057qib7 350 1 The the DT cord-005453-4057qib7 350 2 treatment treatment NN cord-005453-4057qib7 350 3 has have VBZ cord-005453-4057qib7 350 4 low low JJ cord-005453-4057qib7 350 5 costs cost NNS cord-005453-4057qib7 350 6 , , , cord-005453-4057qib7 350 7 can can MD cord-005453-4057qib7 350 8 be be VB cord-005453-4057qib7 350 9 administered administer VBN cord-005453-4057qib7 350 10 on on IN cord-005453-4057qib7 350 11 an an DT cord-005453-4057qib7 350 12 outpatient outpatient NN cord-005453-4057qib7 350 13 basis basis NN cord-005453-4057qib7 350 14 and and CC cord-005453-4057qib7 350 15 is be VBZ cord-005453-4057qib7 350 16 very very RB cord-005453-4057qib7 350 17 well well RB cord-005453-4057qib7 350 18 tolerated tolerate VBN cord-005453-4057qib7 350 19 . . . cord-005453-4057qib7 351 1 Clinical clinical JJ cord-005453-4057qib7 351 2 Background background NN cord-005453-4057qib7 351 3 : : : cord-005453-4057qib7 352 1 Allogenic allogenic JJ cord-005453-4057qib7 352 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 352 3 stem stem NN cord-005453-4057qib7 352 4 cell cell NN cord-005453-4057qib7 352 5 transplant transplant NN cord-005453-4057qib7 352 6 ( ( -LRB- cord-005453-4057qib7 352 7 HSCT HSCT NNP cord-005453-4057qib7 352 8 ) ) -RRB- cord-005453-4057qib7 352 9 is be VBZ cord-005453-4057qib7 352 10 the the DT cord-005453-4057qib7 352 11 only only JJ cord-005453-4057qib7 352 12 curative curative JJ cord-005453-4057qib7 352 13 treatment treatment NN cord-005453-4057qib7 352 14 for for IN cord-005453-4057qib7 352 15 all all PDT cord-005453-4057qib7 352 16 the the DT cord-005453-4057qib7 352 17 patients patient NNS cord-005453-4057qib7 352 18 with with IN cord-005453-4057qib7 352 19 AML AML NNP cord-005453-4057qib7 352 20 . . . cord-005453-4057qib7 353 1 High high JJ cord-005453-4057qib7 353 2 risk risk NN cord-005453-4057qib7 353 3 disease disease NN cord-005453-4057qib7 353 4 qualifies qualify VBZ cord-005453-4057qib7 353 5 for for IN cord-005453-4057qib7 353 6 upfront upfront JJ cord-005453-4057qib7 353 7 HSCT HSCT NNP cord-005453-4057qib7 353 8 irrespective irrespective RB cord-005453-4057qib7 353 9 of of IN cord-005453-4057qib7 353 10 the the DT cord-005453-4057qib7 353 11 presence presence NN cord-005453-4057qib7 353 12 of of IN cord-005453-4057qib7 353 13 matched match VBN cord-005453-4057qib7 353 14 sibling sibling NN cord-005453-4057qib7 353 15 donor donor NN cord-005453-4057qib7 353 16 ( ( -LRB- cord-005453-4057qib7 353 17 MSD MSD NNP cord-005453-4057qib7 353 18 ) ) -RRB- cord-005453-4057qib7 353 19 . . . cord-005453-4057qib7 354 1 In in IN cord-005453-4057qib7 354 2 the the DT cord-005453-4057qib7 354 3 absence absence NN cord-005453-4057qib7 354 4 of of IN cord-005453-4057qib7 354 5 MSD MSD NNP cord-005453-4057qib7 354 6 , , , cord-005453-4057qib7 354 7 haploidentical haploidentical JJ cord-005453-4057qib7 354 8 stem stem NN cord-005453-4057qib7 354 9 cell cell NN cord-005453-4057qib7 354 10 transplant transplant NN cord-005453-4057qib7 354 11 is be VBZ cord-005453-4057qib7 354 12 easier easy JJR cord-005453-4057qib7 354 13 option option NN cord-005453-4057qib7 354 14 with with IN cord-005453-4057qib7 354 15 success success NN cord-005453-4057qib7 354 16 rates rate NNS cord-005453-4057qib7 354 17 as as RB cord-005453-4057qib7 354 18 high high JJ cord-005453-4057qib7 354 19 as as IN cord-005453-4057qib7 354 20 MSD MSD NNP cord-005453-4057qib7 354 21 in in IN cord-005453-4057qib7 354 22 a a DT cord-005453-4057qib7 354 23 high high JJ cord-005453-4057qib7 354 24 volume volume NN cord-005453-4057qib7 354 25 transplant transplant NN cord-005453-4057qib7 354 26 centre centre NN cord-005453-4057qib7 354 27 . . . cord-005453-4057qib7 355 1 We -PRON- PRP cord-005453-4057qib7 355 2 present present VBP cord-005453-4057qib7 355 3 our -PRON- PRP$ cord-005453-4057qib7 355 4 experience experience NN cord-005453-4057qib7 355 5 from from IN cord-005453-4057qib7 355 6 a a DT cord-005453-4057qib7 355 7 single single JJ cord-005453-4057qib7 355 8 centre centre NN cord-005453-4057qib7 355 9 . . . cord-005453-4057qib7 356 1 Methods method NNS cord-005453-4057qib7 356 2 : : : cord-005453-4057qib7 356 3 We -PRON- PRP cord-005453-4057qib7 356 4 analyzed analyze VBD cord-005453-4057qib7 356 5 retrospective retrospective JJ cord-005453-4057qib7 356 6 data datum NNS cord-005453-4057qib7 356 7 of of IN cord-005453-4057qib7 356 8 AML AML NNP cord-005453-4057qib7 356 9 patients patient NNS cord-005453-4057qib7 356 10 who who WP cord-005453-4057qib7 356 11 have have VBP cord-005453-4057qib7 356 12 undergone undergo VBN cord-005453-4057qib7 356 13 HSCT HSCT NNP cord-005453-4057qib7 356 14 at at IN cord-005453-4057qib7 356 15 our -PRON- PRP$ cord-005453-4057qib7 356 16 centre centre NN cord-005453-4057qib7 356 17 between between IN cord-005453-4057qib7 356 18 January-2013 January-2013 NNP cord-005453-4057qib7 356 19 and and CC cord-005453-4057qib7 356 20 August-2018 August-2018 NNP cord-005453-4057qib7 356 21 . . . cord-005453-4057qib7 357 1 For for IN cord-005453-4057qib7 357 2 MSD MSD NNP cord-005453-4057qib7 357 3 transplant transplant NN cord-005453-4057qib7 357 4 we -PRON- PRP cord-005453-4057qib7 357 5 used use VBD cord-005453-4057qib7 357 6 Fludarabine Fludarabine NNP cord-005453-4057qib7 357 7 + + CC cord-005453-4057qib7 357 8 Busulfan Busulfan NNP cord-005453-4057qib7 357 9 or or CC cord-005453-4057qib7 357 10 Fludarabine Fludarabine NNP cord-005453-4057qib7 357 11 + + SYM cord-005453-4057qib7 357 12 Melphalan Melphalan NNP cord-005453-4057qib7 357 13 conditioning conditioning NN cord-005453-4057qib7 357 14 regimen regimen NN cord-005453-4057qib7 357 15 , , , cord-005453-4057qib7 357 16 in in IN cord-005453-4057qib7 357 17 matched match VBN cord-005453-4057qib7 357 18 unrelated unrelated JJ cord-005453-4057qib7 357 19 donor donor NN cord-005453-4057qib7 357 20 transplant transplant NN cord-005453-4057qib7 357 21 ( ( -LRB- cord-005453-4057qib7 357 22 MUD mud NN cord-005453-4057qib7 357 23 ) ) -RRB- cord-005453-4057qib7 357 24 regime regime NN cord-005453-4057qib7 357 25 used use VBN cord-005453-4057qib7 357 26 was be VBD cord-005453-4057qib7 357 27 Fludarabine Fludarabine NNP cord-005453-4057qib7 357 28 + + CC cord-005453-4057qib7 357 29 Busulfan Busulfan NNP cord-005453-4057qib7 357 30 + + SYM cord-005453-4057qib7 357 31 ATG ATG NNP cord-005453-4057qib7 357 32 . . . cord-005453-4057qib7 358 1 We -PRON- PRP cord-005453-4057qib7 358 2 followed follow VBD cord-005453-4057qib7 358 3 John John NNP cord-005453-4057qib7 358 4 Hopkins Hopkins NNP cord-005453-4057qib7 358 5 's 's POS cord-005453-4057qib7 358 6 protocol protocol NN cord-005453-4057qib7 358 7 for for IN cord-005453-4057qib7 358 8 haploidentical haploidentical JJ cord-005453-4057qib7 358 9 HSCT HSCT NNP cord-005453-4057qib7 358 10 . . . cord-005453-4057qib7 359 1 Cyclosporine cyclosporine NN cord-005453-4057qib7 359 2 + + CC cord-005453-4057qib7 359 3 methotrexate methotrexate NNP cord-005453-4057qib7 359 4 was be VBD cord-005453-4057qib7 359 5 used use VBN cord-005453-4057qib7 359 6 as as IN cord-005453-4057qib7 359 7 GVHD GVHD NNP cord-005453-4057qib7 359 8 prophylaxis prophylaxis NN cord-005453-4057qib7 359 9 in in IN cord-005453-4057qib7 359 10 MSD MSD NNP cord-005453-4057qib7 359 11 and and CC cord-005453-4057qib7 359 12 unrelated unrelated JJ cord-005453-4057qib7 359 13 donor donor NN cord-005453-4057qib7 359 14 group group NN cord-005453-4057qib7 359 15 and and CC cord-005453-4057qib7 359 16 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 359 17 + + CC cord-005453-4057qib7 359 18 tacrolimus tacrolimus NN cord-005453-4057qib7 359 19 + + CC cord-005453-4057qib7 359 20 mycophenolate mycophenolate NNP cord-005453-4057qib7 359 21 was be VBD cord-005453-4057qib7 359 22 used use VBN cord-005453-4057qib7 359 23 for for IN cord-005453-4057qib7 359 24 haploidentical haploidentical JJ cord-005453-4057qib7 359 25 post post JJ cord-005453-4057qib7 359 26 - - NN cord-005453-4057qib7 359 27 transplant transplant NN cord-005453-4057qib7 359 28 . . . cord-005453-4057qib7 360 1 Day day NN cord-005453-4057qib7 360 2 100 100 CD cord-005453-4057qib7 360 3 Survival Survival NNP cord-005453-4057qib7 360 4 , , , cord-005453-4057qib7 360 5 overall overall JJ cord-005453-4057qib7 360 6 survival survival NN cord-005453-4057qib7 360 7 ( ( -LRB- cord-005453-4057qib7 360 8 OS OS NNP cord-005453-4057qib7 360 9 ) ) -RRB- cord-005453-4057qib7 360 10 , , , cord-005453-4057qib7 360 11 incidence incidence NN cord-005453-4057qib7 360 12 of of IN cord-005453-4057qib7 360 13 GVHD GVHD NNP cord-005453-4057qib7 360 14 and and CC cord-005453-4057qib7 360 15 CMV CMV NNP cord-005453-4057qib7 360 16 reactivation reactivation NN cord-005453-4057qib7 360 17 was be VBD cord-005453-4057qib7 360 18 computed compute VBN cord-005453-4057qib7 360 19 . . . cord-005453-4057qib7 361 1 Results result NNS cord-005453-4057qib7 361 2 : : : cord-005453-4057qib7 362 1 A a DT cord-005453-4057qib7 362 2 total total NN cord-005453-4057qib7 362 3 of of IN cord-005453-4057qib7 362 4 96 96 CD cord-005453-4057qib7 362 5 AML AML NNP cord-005453-4057qib7 362 6 patients patient NNS cord-005453-4057qib7 362 7 underwent undergo VBD cord-005453-4057qib7 362 8 HSCT HSCT NNP cord-005453-4057qib7 362 9 during during IN cord-005453-4057qib7 362 10 the the DT cord-005453-4057qib7 362 11 study study NN cord-005453-4057qib7 362 12 period period NN cord-005453-4057qib7 362 13 , , , cord-005453-4057qib7 362 14 the the DT cord-005453-4057qib7 362 15 basic basic JJ cord-005453-4057qib7 362 16 and and CC cord-005453-4057qib7 362 17 clinical clinical JJ cord-005453-4057qib7 362 18 characteristics characteristic NNS cord-005453-4057qib7 362 19 of of IN cord-005453-4057qib7 362 20 the the DT cord-005453-4057qib7 362 21 study study NN cord-005453-4057qib7 362 22 patients patient NNS cord-005453-4057qib7 362 23 are be VBP cord-005453-4057qib7 362 24 presented present VBN cord-005453-4057qib7 362 25 in in IN cord-005453-4057qib7 362 26 Table Table NNP cord-005453-4057qib7 362 27 1 1 CD cord-005453-4057qib7 362 28 . . . cord-005453-4057qib7 363 1 Conditioning conditioning NN cord-005453-4057qib7 363 2 regime regime NN cord-005453-4057qib7 363 3 did do VBD cord-005453-4057qib7 363 4 not not RB cord-005453-4057qib7 363 5 have have VB cord-005453-4057qib7 363 6 significant significant JJ cord-005453-4057qib7 363 7 impact impact NN cord-005453-4057qib7 363 8 on on IN cord-005453-4057qib7 363 9 OS OS NNP cord-005453-4057qib7 363 10 . . . cord-005453-4057qib7 364 1 Survival survival NN cord-005453-4057qib7 364 2 at at IN cord-005453-4057qib7 364 3 day day NN cord-005453-4057qib7 364 4 100 100 CD cord-005453-4057qib7 364 5 was be VBD cord-005453-4057qib7 364 6 78 78 CD cord-005453-4057qib7 364 7 % % NN cord-005453-4057qib7 364 8 . . . cord-005453-4057qib7 365 1 The the DT cord-005453-4057qib7 365 2 OS OS NNP cord-005453-4057qib7 365 3 function function NN cord-005453-4057qib7 365 4 and and CC cord-005453-4057qib7 365 5 relapse relapse VB cord-005453-4057qib7 365 6 free free JJ cord-005453-4057qib7 365 7 survival survival NN cord-005453-4057qib7 366 1 ( ( -LRB- cord-005453-4057qib7 366 2 RFS RFS NNP cord-005453-4057qib7 366 3 ) ) -RRB- cord-005453-4057qib7 366 4 function function NN cord-005453-4057qib7 366 5 did do VBD cord-005453-4057qib7 366 6 not not RB cord-005453-4057qib7 366 7 significantly significantly RB cord-005453-4057qib7 366 8 differ differ VB cord-005453-4057qib7 366 9 between between IN cord-005453-4057qib7 366 10 MSD MSD NNP cord-005453-4057qib7 366 11 and and CC cord-005453-4057qib7 366 12 Haploidentical Haploidentical NNP cord-005453-4057qib7 366 13 transplantation transplantation NN cord-005453-4057qib7 366 14 ( ( -LRB- cord-005453-4057qib7 366 15 68.3 68.3 CD cord-005453-4057qib7 366 16 % % NN cord-005453-4057qib7 366 17 vs vs IN cord-005453-4057qib7 366 18 60.0 60.0 CD cord-005453-4057qib7 366 19 % % NN cord-005453-4057qib7 366 20 ; ; : cord-005453-4057qib7 366 21 p=0.225 p=0.225 NNP cord-005453-4057qib7 366 22 ) ) -RRB- cord-005453-4057qib7 366 23 and and CC cord-005453-4057qib7 366 24 ( ( -LRB- cord-005453-4057qib7 366 25 68.3 68.3 CD cord-005453-4057qib7 366 26 % % NN cord-005453-4057qib7 366 27 vs vs IN cord-005453-4057qib7 366 28 75.0 75.0 CD cord-005453-4057qib7 366 29 % % NN cord-005453-4057qib7 366 30 ; ; : cord-005453-4057qib7 366 31 p=0.760 p=0.760 NNP cord-005453-4057qib7 366 32 ) ) -RRB- cord-005453-4057qib7 367 1 ( ( -LRB- cord-005453-4057qib7 367 2 Graph graph NN cord-005453-4057qib7 367 3 1 1 CD cord-005453-4057qib7 367 4 ) ) -RRB- cord-005453-4057qib7 367 5 . . . cord-005453-4057qib7 368 1 Disease disease NN cord-005453-4057qib7 368 2 status status NN cord-005453-4057qib7 368 3 at at IN cord-005453-4057qib7 368 4 latest late JJS cord-005453-4057qib7 368 5 follow follow NN cord-005453-4057qib7 368 6 up up RP cord-005453-4057qib7 368 7 showed show VBD cord-005453-4057qib7 368 8 that that IN cord-005453-4057qib7 368 9 82 82 CD cord-005453-4057qib7 368 10 % % NN cord-005453-4057qib7 368 11 were be VBD cord-005453-4057qib7 368 12 in in IN cord-005453-4057qib7 368 13 remission remission NN cord-005453-4057qib7 368 14 and and CC cord-005453-4057qib7 368 15 18 18 CD cord-005453-4057qib7 368 16 % % NN cord-005453-4057qib7 368 17 had have VBD cord-005453-4057qib7 368 18 relapsed relapse VBN cord-005453-4057qib7 368 19 . . . cord-005453-4057qib7 369 1 Overall overall RB cord-005453-4057qib7 369 2 one one CD cord-005453-4057qib7 369 3 year year NN cord-005453-4057qib7 369 4 survival survival NN cord-005453-4057qib7 369 5 and and CC cord-005453-4057qib7 369 6 five five CD cord-005453-4057qib7 369 7 year year NN cord-005453-4057qib7 369 8 survival survival NN cord-005453-4057qib7 369 9 in in IN cord-005453-4057qib7 369 10 the the DT cord-005453-4057qib7 369 11 entire entire JJ cord-005453-4057qib7 369 12 cohort cohort NN cord-005453-4057qib7 369 13 was be VBD cord-005453-4057qib7 369 14 68 68 CD cord-005453-4057qib7 369 15 % % NN cord-005453-4057qib7 369 16 and and CC cord-005453-4057qib7 369 17 58 58 CD cord-005453-4057qib7 369 18 % % NN cord-005453-4057qib7 369 19 respectively respectively RB cord-005453-4057qib7 369 20 . . . cord-005453-4057qib7 370 1 The the DT cord-005453-4057qib7 370 2 average average JJ cord-005453-4057qib7 370 3 cost cost NN cord-005453-4057qib7 370 4 of of IN cord-005453-4057qib7 370 5 MSD MSD NNP cord-005453-4057qib7 370 6 transplant transplant NN cord-005453-4057qib7 370 7 at at IN cord-005453-4057qib7 370 8 our -PRON- PRP$ cord-005453-4057qib7 370 9 centre centre NN cord-005453-4057qib7 370 10 is be VBZ cord-005453-4057qib7 370 11 INR INR NNP cord-005453-4057qib7 370 12 10,00,000 10,00,000 CD cord-005453-4057qib7 371 1 ( ( -LRB- cord-005453-4057qib7 371 2 € € $ cord-005453-4057qib7 371 3 10000 10000 CD cord-005453-4057qib7 371 4 - - HYPH cord-005453-4057qib7 371 5 12000 12000 CD cord-005453-4057qib7 371 6 ) ) -RRB- cord-005453-4057qib7 371 7 , , , cord-005453-4057qib7 371 8 haploidentical haploidentical JJ cord-005453-4057qib7 371 9 transplant transplant NN cord-005453-4057qib7 371 10 is be VBZ cord-005453-4057qib7 371 11 INR INR NNP cord-005453-4057qib7 371 12 20,00,000 20,00,000 CD cord-005453-4057qib7 372 1 ( ( -LRB- cord-005453-4057qib7 372 2 € € $ cord-005453-4057qib7 372 3 25000 25000 CD cord-005453-4057qib7 372 4 - - HYPH cord-005453-4057qib7 372 5 27000 27000 CD cord-005453-4057qib7 372 6 ) ) -RRB- cord-005453-4057qib7 373 1 and and CC cord-005453-4057qib7 373 2 MUD mud NN cord-005453-4057qib7 373 3 transplant transplant NN cord-005453-4057qib7 373 4 is be VBZ cord-005453-4057qib7 373 5 INR INR NNP cord-005453-4057qib7 373 6 32,00,000 32,00,000 CD cord-005453-4057qib7 374 1 ( ( -LRB- cord-005453-4057qib7 374 2 € € $ cord-005453-4057qib7 374 3 30,000 30,000 CD cord-005453-4057qib7 374 4 + + SYM cord-005453-4057qib7 374 5 10000 10000 CD cord-005453-4057qib7 374 6 for for IN cord-005453-4057qib7 374 7 stem stem NN cord-005453-4057qib7 374 8 cell cell NN cord-005453-4057qib7 374 9 procurement procurement NN cord-005453-4057qib7 374 10 ) ) -RRB- cord-005453-4057qib7 374 11 . . . cord-005453-4057qib7 375 1 Conclusions conclusion NNS cord-005453-4057qib7 375 2 : : : cord-005453-4057qib7 376 1 Our -PRON- PRP$ cord-005453-4057qib7 376 2 study study NN cord-005453-4057qib7 376 3 showed show VBD cord-005453-4057qib7 376 4 comparable comparable JJ cord-005453-4057qib7 376 5 outcomes outcome NNS cord-005453-4057qib7 376 6 in in IN cord-005453-4057qib7 376 7 MSD MSD NNP cord-005453-4057qib7 376 8 and and CC cord-005453-4057qib7 376 9 Haploidentical Haploidentical NNP cord-005453-4057qib7 376 10 transplant transplant NN cord-005453-4057qib7 376 11 with with IN cord-005453-4057qib7 376 12 respect respect NN cord-005453-4057qib7 376 13 to to IN cord-005453-4057qib7 376 14 Day100 day100 JJ cord-005453-4057qib7 376 15 survival survival NN cord-005453-4057qib7 376 16 , , , cord-005453-4057qib7 376 17 OS OS NNP cord-005453-4057qib7 376 18 , , , cord-005453-4057qib7 376 19 and and CC cord-005453-4057qib7 376 20 rate rate NN cord-005453-4057qib7 376 21 of of IN cord-005453-4057qib7 376 22 GVHD GVHD NNP cord-005453-4057qib7 376 23 . . . cord-005453-4057qib7 377 1 In in IN cord-005453-4057qib7 377 2 a a DT cord-005453-4057qib7 377 3 developing develop VBG cord-005453-4057qib7 377 4 country country NN cord-005453-4057qib7 377 5 like like IN cord-005453-4057qib7 377 6 India India NNP cord-005453-4057qib7 377 7 where where WRB cord-005453-4057qib7 377 8 patients patient NNS cord-005453-4057qib7 377 9 are be VBP cord-005453-4057qib7 377 10 not not RB cord-005453-4057qib7 377 11 covered cover VBN cord-005453-4057qib7 377 12 under under IN cord-005453-4057qib7 377 13 state state NN cord-005453-4057qib7 377 14 health health NN cord-005453-4057qib7 377 15 insurance insurance NN cord-005453-4057qib7 377 16 , , , cord-005453-4057qib7 377 17 the the DT cord-005453-4057qib7 377 18 additional additional JJ cord-005453-4057qib7 377 19 cost cost NN cord-005453-4057qib7 377 20 of of IN cord-005453-4057qib7 377 21 procurement procurement NN cord-005453-4057qib7 377 22 of of IN cord-005453-4057qib7 377 23 stem stem NN cord-005453-4057qib7 377 24 cells cell NNS cord-005453-4057qib7 377 25 in in IN cord-005453-4057qib7 377 26 a a DT cord-005453-4057qib7 377 27 MUD mud NN cord-005453-4057qib7 377 28 transplant transplant NN cord-005453-4057qib7 377 29 would would MD cord-005453-4057qib7 377 30 add add VB cord-005453-4057qib7 377 31 to to IN cord-005453-4057qib7 377 32 the the DT cord-005453-4057qib7 377 33 financial financial JJ cord-005453-4057qib7 377 34 burden burden NN cord-005453-4057qib7 377 35 to to IN cord-005453-4057qib7 377 36 the the DT cord-005453-4057qib7 377 37 patients patient NNS cord-005453-4057qib7 377 38 . . . cord-005453-4057qib7 378 1 Haploidentical haploidentical JJ cord-005453-4057qib7 378 2 transplant transplant NN cord-005453-4057qib7 378 3 is be VBZ cord-005453-4057qib7 378 4 a a DT cord-005453-4057qib7 378 5 feasible feasible JJ cord-005453-4057qib7 378 6 option option NN cord-005453-4057qib7 378 7 in in IN cord-005453-4057qib7 378 8 case case NN cord-005453-4057qib7 378 9 of of IN cord-005453-4057qib7 378 10 non non JJ cord-005453-4057qib7 378 11 - - JJ cord-005453-4057qib7 378 12 availability availability NN cord-005453-4057qib7 378 13 of of IN cord-005453-4057qib7 378 14 MSD MSD NNP cord-005453-4057qib7 378 15 , , , cord-005453-4057qib7 378 16 due due JJ cord-005453-4057qib7 378 17 to to IN cord-005453-4057qib7 378 18 ease ease NN cord-005453-4057qib7 378 19 of of IN cord-005453-4057qib7 378 20 donor donor NN cord-005453-4057qib7 378 21 availability availability NN cord-005453-4057qib7 378 22 and and CC cord-005453-4057qib7 378 23 strong strong JJ cord-005453-4057qib7 378 24 motivation motivation NN cord-005453-4057qib7 378 25 from from IN cord-005453-4057qib7 378 26 the the DT cord-005453-4057qib7 378 27 family family NN cord-005453-4057qib7 378 28 donor donor NN cord-005453-4057qib7 378 29 to to TO cord-005453-4057qib7 378 30 donate donate VB cord-005453-4057qib7 378 31 the the DT cord-005453-4057qib7 378 32 stem stem NN cord-005453-4057qib7 378 33 cells cell NNS cord-005453-4057qib7 378 34 . . . cord-005453-4057qib7 379 1 Background background NN cord-005453-4057qib7 379 2 : : : cord-005453-4057qib7 380 1 Allogeneic allogeneic IN cord-005453-4057qib7 380 2 stem stem VBP cord-005453-4057qib7 380 3 cell cell NN cord-005453-4057qib7 380 4 transplantation transplantation NN cord-005453-4057qib7 380 5 ( ( -LRB- cord-005453-4057qib7 380 6 allo allo NN cord-005453-4057qib7 380 7 - - HYPH cord-005453-4057qib7 380 8 HSCT HSCT NNP cord-005453-4057qib7 380 9 ) ) -RRB- cord-005453-4057qib7 380 10 is be VBZ cord-005453-4057qib7 380 11 not not RB cord-005453-4057qib7 380 12 indicated indicate VBN cord-005453-4057qib7 380 13 as as IN cord-005453-4057qib7 380 14 consolidation consolidation NN cord-005453-4057qib7 380 15 of of IN cord-005453-4057qib7 380 16 first first JJ cord-005453-4057qib7 380 17 complete complete JJ cord-005453-4057qib7 380 18 remission remission NN cord-005453-4057qib7 380 19 ( ( -LRB- cord-005453-4057qib7 380 20 CR1 CR1 NNP cord-005453-4057qib7 380 21 ) ) -RRB- cord-005453-4057qib7 380 22 in in IN cord-005453-4057qib7 380 23 favorable favorable JJ cord-005453-4057qib7 380 24 - - HYPH cord-005453-4057qib7 380 25 risk risk NN cord-005453-4057qib7 380 26 acute acute JJ cord-005453-4057qib7 380 27 myeloid myeloid NN cord-005453-4057qib7 380 28 leukemia leukemia NN cord-005453-4057qib7 380 29 ( ( -LRB- cord-005453-4057qib7 380 30 AML AML NNP cord-005453-4057qib7 380 31 ) ) -RRB- cord-005453-4057qib7 380 32 bearing bearing NN cord-005453-4057qib7 380 33 mutations mutation NNS cord-005453-4057qib7 380 34 in in IN cord-005453-4057qib7 380 35 nucleophosmin nucleophosmin NNP cord-005453-4057qib7 380 36 ( ( -LRB- cord-005453-4057qib7 380 37 NPM1 NPM1 NNP cord-005453-4057qib7 380 38 ) ) -RRB- cord-005453-4057qib7 380 39 in in IN cord-005453-4057qib7 380 40 the the DT cord-005453-4057qib7 380 41 absence absence NN cord-005453-4057qib7 380 42 of of IN cord-005453-4057qib7 380 43 FLT3 FLT3 NNP cord-005453-4057qib7 380 44 internal internal JJ cord-005453-4057qib7 380 45 tandem tandem NN cord-005453-4057qib7 380 46 duplication duplication NN cord-005453-4057qib7 380 47 ( ( -LRB- cord-005453-4057qib7 380 48 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 380 49 ) ) -RRB- cord-005453-4057qib7 380 50 . . . cord-005453-4057qib7 381 1 Nevertheless nevertheless RB cord-005453-4057qib7 381 2 , , , cord-005453-4057qib7 381 3 a a DT cord-005453-4057qib7 381 4 substantial substantial JJ cord-005453-4057qib7 381 5 proportion proportion NN cord-005453-4057qib7 381 6 of of IN cord-005453-4057qib7 381 7 patients patient NNS cord-005453-4057qib7 381 8 eventually eventually RB cord-005453-4057qib7 381 9 proceed proceed VBP cord-005453-4057qib7 381 10 to to TO cord-005453-4057qib7 381 11 allo allo VB cord-005453-4057qib7 381 12 - - HYPH cord-005453-4057qib7 381 13 HSCT HSCT NNP cord-005453-4057qib7 381 14 beyond beyond IN cord-005453-4057qib7 381 15 CR1 CR1 NNP cord-005453-4057qib7 381 16 or or CC cord-005453-4057qib7 381 17 for for IN cord-005453-4057qib7 381 18 chemoresistant chemoresistant JJ cord-005453-4057qib7 381 19 minimal minimal JJ cord-005453-4057qib7 381 20 residual residual JJ cord-005453-4057qib7 381 21 disease disease NN cord-005453-4057qib7 381 22 ( ( -LRB- cord-005453-4057qib7 381 23 MRD MRD NNP cord-005453-4057qib7 381 24 ) ) -RRB- cord-005453-4057qib7 381 25 while while IN cord-005453-4057qib7 381 26 in in IN cord-005453-4057qib7 381 27 CR1 CR1 NNP cord-005453-4057qib7 381 28 , , , cord-005453-4057qib7 381 29 which which WDT cord-005453-4057qib7 381 30 might may MD cord-005453-4057qib7 381 31 compromise compromise VB cord-005453-4057qib7 381 32 transplantation transplantation NN cord-005453-4057qib7 381 33 outcomes outcome NNS cord-005453-4057qib7 381 34 . . . cord-005453-4057qib7 382 1 The the DT cord-005453-4057qib7 382 2 study study NN cord-005453-4057qib7 382 3 aimed aim VBN cord-005453-4057qib7 382 4 at at IN cord-005453-4057qib7 382 5 examining examine VBG cord-005453-4057qib7 382 6 the the DT cord-005453-4057qib7 382 7 characteristics characteristic NNS cord-005453-4057qib7 382 8 and and CC cord-005453-4057qib7 382 9 results result NNS cord-005453-4057qib7 382 10 of of IN cord-005453-4057qib7 382 11 allo allo NN cord-005453-4057qib7 382 12 - - HYPH cord-005453-4057qib7 382 13 HSCT HSCT NNP cord-005453-4057qib7 382 14 in in IN cord-005453-4057qib7 382 15 AML AML NNP cord-005453-4057qib7 382 16 cases case NNS cord-005453-4057qib7 382 17 with with IN cord-005453-4057qib7 382 18 mutated mutate VBN cord-005453-4057qib7 382 19 NPM1 NPM1 NNP cord-005453-4057qib7 382 20 and and CC cord-005453-4057qib7 382 21 wild wild JJ cord-005453-4057qib7 382 22 - - HYPH cord-005453-4057qib7 382 23 type type NN cord-005453-4057qib7 382 24 FLT3 FLT3 NNP cord-005453-4057qib7 383 1 ( ( -LRB- cord-005453-4057qib7 383 2 NPM1mut NPM1mut NNP cord-005453-4057qib7 383 3 / / SYM cord-005453-4057qib7 383 4 FLT3wt FLT3wt NNP cord-005453-4057qib7 383 5 ) ) -RRB- cord-005453-4057qib7 383 6 , , , cord-005453-4057qib7 383 7 with with IN cord-005453-4057qib7 383 8 special special JJ cord-005453-4057qib7 383 9 focus focus NN cord-005453-4057qib7 383 10 on on IN cord-005453-4057qib7 383 11 molecular molecular JJ cord-005453-4057qib7 383 12 monitoring monitoring NN cord-005453-4057qib7 383 13 of of IN cord-005453-4057qib7 383 14 MRD MRD NNP cord-005453-4057qib7 383 15 following follow VBG cord-005453-4057qib7 383 16 transplantation transplantation NN cord-005453-4057qib7 383 17 . . . cord-005453-4057qib7 384 1 Methods method NNS cord-005453-4057qib7 384 2 : : : cord-005453-4057qib7 385 1 From from IN cord-005453-4057qib7 385 2 11/2010 11/2010 CD cord-005453-4057qib7 385 3 until until IN cord-005453-4057qib7 385 4 04/2018 04/2018 CD cord-005453-4057qib7 385 5 , , , cord-005453-4057qib7 385 6 16 16 CD cord-005453-4057qib7 385 7 patients patient NNS cord-005453-4057qib7 385 8 ( ( -LRB- cord-005453-4057qib7 385 9 women woman NNS cord-005453-4057qib7 385 10 / / SYM cord-005453-4057qib7 385 11 men man NNS cord-005453-4057qib7 385 12 , , , cord-005453-4057qib7 385 13 9/7 9/7 CD cord-005453-4057qib7 385 14 ) ) -RRB- cord-005453-4057qib7 385 15 underwent undergo VBD cord-005453-4057qib7 385 16 allo allo NN cord-005453-4057qib7 385 17 - - HYPH cord-005453-4057qib7 385 18 HSCT HSCT NNP cord-005453-4057qib7 385 19 for for IN cord-005453-4057qib7 385 20 NPM1mut/ NPM1mut/ NNP cord-005453-4057qib7 386 1 FLT3wt FLT3wt NNP cord-005453-4057qib7 386 2 AML AML NNP cord-005453-4057qib7 386 3 . . . cord-005453-4057qib7 387 1 At at IN cord-005453-4057qib7 387 2 transplant transplant NN cord-005453-4057qib7 387 3 , , , cord-005453-4057qib7 387 4 median median JJ cord-005453-4057qib7 387 5 age age NN cord-005453-4057qib7 387 6 of of IN cord-005453-4057qib7 387 7 patients patient NNS cord-005453-4057qib7 387 8 was be VBD cord-005453-4057qib7 387 9 44.5 44.5 CD cord-005453-4057qib7 387 10 years year NNS cord-005453-4057qib7 388 1 ( ( -LRB- cord-005453-4057qib7 388 2 range range NN cord-005453-4057qib7 388 3 , , , cord-005453-4057qib7 388 4 35 35 CD cord-005453-4057qib7 388 5 - - SYM cord-005453-4057qib7 388 6 63 63 CD cord-005453-4057qib7 388 7 ) ) -RRB- cord-005453-4057qib7 388 8 , , , cord-005453-4057qib7 388 9 and and CC cord-005453-4057qib7 389 1 disease disease NNP cord-005453-4057qib7 389 2 phase phase NN cord-005453-4057qib7 389 3 was be VBD cord-005453-4057qib7 389 4 CR1 CR1 NNP cord-005453-4057qib7 389 5 ( ( -LRB- cord-005453-4057qib7 389 6 n=5 n=5 NNP cord-005453-4057qib7 389 7 ) ) -RRB- cord-005453-4057qib7 389 8 , , , cord-005453-4057qib7 389 9 CR2 CR2 NNP cord-005453-4057qib7 389 10 ( ( -LRB- cord-005453-4057qib7 389 11 n=9 n=9 NN cord-005453-4057qib7 389 12 ) ) -RRB- cord-005453-4057qib7 389 13 , , , cord-005453-4057qib7 389 14 or or CC cord-005453-4057qib7 389 15 primary primary JJ cord-005453-4057qib7 389 16 refractory refractory NN cord-005453-4057qib7 389 17 ( ( -LRB- cord-005453-4057qib7 389 18 n=2 n=2 NNS cord-005453-4057qib7 389 19 ) ) -RRB- cord-005453-4057qib7 389 20 . . . cord-005453-4057qib7 390 1 Among among IN cord-005453-4057qib7 390 2 the the DT cord-005453-4057qib7 390 3 13 13 CD cord-005453-4057qib7 390 4 patients patient NNS cord-005453-4057qib7 390 5 who who WP cord-005453-4057qib7 390 6 were be VBD cord-005453-4057qib7 390 7 transplanted transplant VBN cord-005453-4057qib7 390 8 in in IN cord-005453-4057qib7 390 9 CR CR NNP cord-005453-4057qib7 390 10 and and CC cord-005453-4057qib7 390 11 had have VBD cord-005453-4057qib7 390 12 available available JJ cord-005453-4057qib7 390 13 molecular molecular JJ cord-005453-4057qib7 390 14 MRD MRD NNP cord-005453-4057qib7 390 15 assessments assessment NNS cord-005453-4057qib7 390 16 , , , cord-005453-4057qib7 390 17 10 10 CD cord-005453-4057qib7 390 18 had have VBD cord-005453-4057qib7 390 19 detectable detectable JJ cord-005453-4057qib7 390 20 mutant mutant JJ cord-005453-4057qib7 390 21 NPM1 NPM1 NNP cord-005453-4057qib7 390 22 transcripts transcript NNS cord-005453-4057qib7 390 23 by by IN cord-005453-4057qib7 390 24 real real JJ cord-005453-4057qib7 390 25 - - HYPH cord-005453-4057qib7 390 26 time time NN cord-005453-4057qib7 390 27 quantitative quantitative JJ cord-005453-4057qib7 390 28 PCR PCR NNP cord-005453-4057qib7 390 29 ( ( -LRB- cord-005453-4057qib7 390 30 RQ RQ NNP cord-005453-4057qib7 390 31 - - HYPH cord-005453-4057qib7 390 32 RCR RCR NNP cord-005453-4057qib7 390 33 ) ) -RRB- cord-005453-4057qib7 390 34 . . . cord-005453-4057qib7 391 1 Also also RB cord-005453-4057qib7 391 2 , , , cord-005453-4057qib7 391 3 4 4 CD cord-005453-4057qib7 391 4 patients patient NNS cord-005453-4057qib7 391 5 fulfilled fulfil VBD cord-005453-4057qib7 391 6 criteria criterion NNS cord-005453-4057qib7 391 7 of of IN cord-005453-4057qib7 391 8 molecular molecular JJ cord-005453-4057qib7 391 9 relapse relapse NN cord-005453-4057qib7 391 10 ( ( -LRB- cord-005453-4057qib7 391 11 increasing increase VBG cord-005453-4057qib7 391 12 levels level NNS cord-005453-4057qib7 391 13 of of IN cord-005453-4057qib7 391 14 NPM1-mutated npm1-mutated JJ cord-005453-4057qib7 391 15 transcripts transcript NNS cord-005453-4057qib7 391 16 in in IN cord-005453-4057qib7 391 17 two two CD cord-005453-4057qib7 391 18 successive successive JJ cord-005453-4057qib7 391 19 bone bone NN cord-005453-4057qib7 391 20 marrow marrow NN cord-005453-4057qib7 391 21 samples sample NNS cord-005453-4057qib7 391 22 ) ) -RRB- cord-005453-4057qib7 391 23 , , , cord-005453-4057qib7 391 24 with with IN cord-005453-4057qib7 391 25 mutant mutant JJ cord-005453-4057qib7 391 26 NPM1 NPM1 NNP cord-005453-4057qib7 391 27 load load NN cord-005453-4057qib7 391 28 of of IN cord-005453-4057qib7 391 29 386 386 CD cord-005453-4057qib7 391 30 - - SYM cord-005453-4057qib7 391 31 4,900 4,900 CD cord-005453-4057qib7 391 32 transcripts/10,000 transcripts/10,000 NNP cord-005453-4057qib7 391 33 ABL ABL NNP cord-005453-4057qib7 391 34 transcripts transcript NNS cord-005453-4057qib7 391 35 ) ) -RRB- cord-005453-4057qib7 391 36 . . . cord-005453-4057qib7 392 1 The the DT cord-005453-4057qib7 392 2 conditioning conditioning NN cord-005453-4057qib7 392 3 regimen regimen NN cord-005453-4057qib7 392 4 was be VBD cord-005453-4057qib7 392 5 myeloablative myeloablative JJ cord-005453-4057qib7 392 6 in in IN cord-005453-4057qib7 392 7 the the DT cord-005453-4057qib7 392 8 majority majority NN cord-005453-4057qib7 392 9 of of IN cord-005453-4057qib7 392 10 cases case NNS cord-005453-4057qib7 392 11 ( ( -LRB- cord-005453-4057qib7 392 12 n=14 n=14 JJ cord-005453-4057qib7 392 13 ) ) -RRB- cord-005453-4057qib7 392 14 or or CC cord-005453-4057qib7 392 15 reduced reduce VBN cord-005453-4057qib7 392 16 - - HYPH cord-005453-4057qib7 392 17 intensity intensity NN cord-005453-4057qib7 392 18 ( ( -LRB- cord-005453-4057qib7 392 19 n=2 n=2 NNS cord-005453-4057qib7 392 20 ) ) -RRB- cord-005453-4057qib7 392 21 . . . cord-005453-4057qib7 393 1 The the DT cord-005453-4057qib7 393 2 type type NN cord-005453-4057qib7 393 3 of of IN cord-005453-4057qib7 393 4 donor donor NN cord-005453-4057qib7 393 5 varied vary VBN cord-005453-4057qib7 393 6 , , , cord-005453-4057qib7 393 7 namely namely RB cord-005453-4057qib7 393 8 HLA HLA NNP cord-005453-4057qib7 393 9 - - HYPH cord-005453-4057qib7 393 10 identical identical JJ cord-005453-4057qib7 393 11 sibling sibling NN cord-005453-4057qib7 393 12 ( ( -LRB- cord-005453-4057qib7 393 13 n=6 n=6 NNP cord-005453-4057qib7 393 14 ) ) -RRB- cord-005453-4057qib7 393 15 , , , cord-005453-4057qib7 393 16 matched match VBN cord-005453-4057qib7 393 17 unrelated unrelated JJ cord-005453-4057qib7 393 18 ( ( -LRB- cord-005453-4057qib7 393 19 n=5 n=5 NNP cord-005453-4057qib7 393 20 ) ) -RRB- cord-005453-4057qib7 393 21 , , , cord-005453-4057qib7 393 22 haploidentical haploidentical JJ cord-005453-4057qib7 393 23 relative relative NN cord-005453-4057qib7 393 24 ( ( -LRB- cord-005453-4057qib7 393 25 n=3 n=3 NN cord-005453-4057qib7 393 26 ) ) -RRB- cord-005453-4057qib7 393 27 , , , cord-005453-4057qib7 393 28 or or CC cord-005453-4057qib7 393 29 double double JJ cord-005453-4057qib7 393 30 umbilical umbilical JJ cord-005453-4057qib7 393 31 cord cord NN cord-005453-4057qib7 393 32 blood blood NN cord-005453-4057qib7 393 33 ( ( -LRB- cord-005453-4057qib7 393 34 n=2 n=2 NNS cord-005453-4057qib7 393 35 ) ) -RRB- cord-005453-4057qib7 393 36 . . . cord-005453-4057qib7 394 1 Results result NNS cord-005453-4057qib7 394 2 : : : cord-005453-4057qib7 395 1 Engraftment Engraftment NNP cord-005453-4057qib7 395 2 was be VBD cord-005453-4057qib7 395 3 achieved achieve VBN cord-005453-4057qib7 395 4 in in IN cord-005453-4057qib7 395 5 all all DT cord-005453-4057qib7 395 6 cases case NNS cord-005453-4057qib7 395 7 , , , cord-005453-4057qib7 395 8 with with IN cord-005453-4057qib7 395 9 a a DT cord-005453-4057qib7 395 10 median median JJ cord-005453-4057qib7 395 11 time time NN cord-005453-4057qib7 395 12 to to IN cord-005453-4057qib7 395 13 absolute absolute JJ cord-005453-4057qib7 395 14 neutrophil neutrophil NN cord-005453-4057qib7 395 15 count count NN cord-005453-4057qib7 395 16 > > XX cord-005453-4057qib7 396 1 500 500 CD cord-005453-4057qib7 396 2 / / SYM cord-005453-4057qib7 396 3 uL ul NN cord-005453-4057qib7 396 4 of of IN cord-005453-4057qib7 396 5 16 16 CD cord-005453-4057qib7 396 6 days day NNS cord-005453-4057qib7 396 7 ( ( -LRB- cord-005453-4057qib7 396 8 range range NN cord-005453-4057qib7 396 9 , , , cord-005453-4057qib7 396 10 12 12 CD cord-005453-4057qib7 396 11 - - SYM cord-005453-4057qib7 396 12 29 29 CD cord-005453-4057qib7 396 13 ) ) -RRB- cord-005453-4057qib7 396 14 . . . cord-005453-4057qib7 397 1 Among among IN cord-005453-4057qib7 397 2 the the DT cord-005453-4057qib7 397 3 13 13 CD cord-005453-4057qib7 397 4 patients patient NNS cord-005453-4057qib7 397 5 with with IN cord-005453-4057qib7 397 6 posttransplant posttransplant NN cord-005453-4057qib7 397 7 monitoring monitoring NN cord-005453-4057qib7 397 8 of of IN cord-005453-4057qib7 397 9 MRD MRD NNP cord-005453-4057qib7 397 10 by by IN cord-005453-4057qib7 397 11 RQ RQ NNP cord-005453-4057qib7 397 12 - - HYPH cord-005453-4057qib7 397 13 PCR PCR NNP cord-005453-4057qib7 397 14 , , , cord-005453-4057qib7 397 15 9 9 CD cord-005453-4057qib7 397 16 exhibited exhibit VBD cord-005453-4057qib7 397 17 a a DT cord-005453-4057qib7 397 18 stable stable JJ cord-005453-4057qib7 397 19 molecular molecular JJ cord-005453-4057qib7 397 20 remission remission NN cord-005453-4057qib7 397 21 whereas whereas IN cord-005453-4057qib7 397 22 a a DT cord-005453-4057qib7 397 23 rising rise VBG cord-005453-4057qib7 397 24 level level NN cord-005453-4057qib7 397 25 of of IN cord-005453-4057qib7 397 26 NPM1mutated npm1mutated JJ cord-005453-4057qib7 397 27 transcripts transcript NNS cord-005453-4057qib7 397 28 was be VBD cord-005453-4057qib7 397 29 observed observe VBN cord-005453-4057qib7 397 30 in in IN cord-005453-4057qib7 397 31 4 4 CD cord-005453-4057qib7 397 32 cases case NNS cord-005453-4057qib7 397 33 due due JJ cord-005453-4057qib7 397 34 to to IN cord-005453-4057qib7 397 35 either either CC cord-005453-4057qib7 397 36 hematologic hematologic JJ cord-005453-4057qib7 397 37 ( ( -LRB- cord-005453-4057qib7 397 38 n=3 n=3 NN cord-005453-4057qib7 397 39 ) ) -RRB- cord-005453-4057qib7 397 40 or or CC cord-005453-4057qib7 397 41 molecular molecular JJ cord-005453-4057qib7 397 42 ( ( -LRB- cord-005453-4057qib7 397 43 n=1 n=1 CD cord-005453-4057qib7 397 44 ) ) -RRB- cord-005453-4057qib7 397 45 relapse relapse NN cord-005453-4057qib7 397 46 of of IN cord-005453-4057qib7 397 47 disease disease NN cord-005453-4057qib7 397 48 . . . cord-005453-4057qib7 398 1 The the DT cord-005453-4057qib7 398 2 cumulative cumulative JJ cord-005453-4057qib7 398 3 incidences incidence NNS cord-005453-4057qib7 398 4 ( ( -LRB- cord-005453-4057qib7 398 5 CIN CIN NNP cord-005453-4057qib7 398 6 ) ) -RRB- cord-005453-4057qib7 398 7 of of IN cord-005453-4057qib7 398 8 hematologic hematologic JJ cord-005453-4057qib7 398 9 relapse relapse NN cord-005453-4057qib7 398 10 and and CC cord-005453-4057qib7 398 11 non non JJ cord-005453-4057qib7 398 12 - - JJ cord-005453-4057qib7 398 13 relapse relapse JJ cord-005453-4057qib7 398 14 mortality mortality NN cord-005453-4057qib7 398 15 ( ( -LRB- cord-005453-4057qib7 398 16 NRM NRM NNP cord-005453-4057qib7 398 17 ) ) -RRB- cord-005453-4057qib7 398 18 were be VBD cord-005453-4057qib7 398 19 18.75 18.75 CD cord-005453-4057qib7 398 20 % % NN cord-005453-4057qib7 398 21 and and CC cord-005453-4057qib7 398 22 25 25 CD cord-005453-4057qib7 398 23 % % NN cord-005453-4057qib7 398 24 at at IN cord-005453-4057qib7 398 25 12 12 CD cord-005453-4057qib7 398 26 months month NNS cord-005453-4057qib7 398 27 , , , cord-005453-4057qib7 398 28 respectively respectively RB cord-005453-4057qib7 398 29 . . . cord-005453-4057qib7 399 1 No no DT cord-005453-4057qib7 399 2 events event NNS cord-005453-4057qib7 399 3 of of IN cord-005453-4057qib7 399 4 relapse relapse NN cord-005453-4057qib7 399 5 or or CC cord-005453-4057qib7 399 6 NRM NRM NNP cord-005453-4057qib7 399 7 were be VBD cord-005453-4057qib7 399 8 encountered encounter VBN cord-005453-4057qib7 399 9 beyond beyond IN cord-005453-4057qib7 399 10 6 6 CD cord-005453-4057qib7 399 11 months month NNS cord-005453-4057qib7 399 12 from from IN cord-005453-4057qib7 399 13 allo allo NN cord-005453-4057qib7 399 14 - - HYPH cord-005453-4057qib7 399 15 HSCT HSCT NNP cord-005453-4057qib7 399 16 . . . cord-005453-4057qib7 400 1 Out out IN cord-005453-4057qib7 400 2 of of IN cord-005453-4057qib7 400 3 3 3 CD cord-005453-4057qib7 400 4 patients patient NNS cord-005453-4057qib7 400 5 with with IN cord-005453-4057qib7 400 6 hematologic hematologic JJ cord-005453-4057qib7 400 7 relapse relapse NN cord-005453-4057qib7 400 8 post post NN cord-005453-4057qib7 400 9 transplant transplant NN cord-005453-4057qib7 400 10 , , , cord-005453-4057qib7 400 11 2 2 CD cord-005453-4057qib7 400 12 died die VBD cord-005453-4057qib7 400 13 of of IN cord-005453-4057qib7 400 14 disease disease NN cord-005453-4057qib7 400 15 whereas whereas IN cord-005453-4057qib7 400 16 one one CD cord-005453-4057qib7 400 17 achieved achieve VBD cord-005453-4057qib7 400 18 a a DT cord-005453-4057qib7 400 19 stable stable JJ cord-005453-4057qib7 400 20 complete complete JJ cord-005453-4057qib7 400 21 remission remission NN cord-005453-4057qib7 400 22 after after IN cord-005453-4057qib7 400 23 withdrawal withdrawal NN cord-005453-4057qib7 400 24 of of IN cord-005453-4057qib7 400 25 immunosuppression immunosuppression NN cord-005453-4057qib7 400 26 . . . cord-005453-4057qib7 401 1 At at IN cord-005453-4057qib7 401 2 a a DT cord-005453-4057qib7 401 3 median median JJ cord-005453-4057qib7 401 4 follow follow NN cord-005453-4057qib7 401 5 - - HYPH cord-005453-4057qib7 401 6 up up NN cord-005453-4057qib7 401 7 time time NN cord-005453-4057qib7 401 8 of of IN cord-005453-4057qib7 401 9 40 40 CD cord-005453-4057qib7 401 10 months month NNS cord-005453-4057qib7 401 11 ( ( -LRB- cord-005453-4057qib7 401 12 range range NN cord-005453-4057qib7 401 13 , , , cord-005453-4057qib7 401 14 14 14 CD cord-005453-4057qib7 401 15 - - SYM cord-005453-4057qib7 401 16 89 89 CD cord-005453-4057qib7 401 17 ) ) -RRB- cord-005453-4057qib7 401 18 , , , cord-005453-4057qib7 401 19 10/16 10/16 CD cord-005453-4057qib7 401 20 patients patient NNS cord-005453-4057qib7 401 21 continue continue VBP cord-005453-4057qib7 401 22 to to TO cord-005453-4057qib7 401 23 be be VB cord-005453-4057qib7 401 24 alive alive JJ cord-005453-4057qib7 401 25 in in IN cord-005453-4057qib7 401 26 CR CR NNP cord-005453-4057qib7 401 27 . . . cord-005453-4057qib7 402 1 The the DT cord-005453-4057qib7 402 2 estimated estimate VBN cord-005453-4057qib7 402 3 disease disease NN cord-005453-4057qib7 402 4 - - HYPH cord-005453-4057qib7 402 5 free free JJ cord-005453-4057qib7 402 6 Background background NN cord-005453-4057qib7 402 7 : : : cord-005453-4057qib7 402 8 CPX-351 cpx-351 NN cord-005453-4057qib7 403 1 ( ( -LRB- cord-005453-4057qib7 403 2 Vyxeos Vyxeos NNP cord-005453-4057qib7 403 3 ® ® . cord-005453-4057qib7 403 4 ) ) -RRB- cord-005453-4057qib7 403 5 is be VBZ cord-005453-4057qib7 403 6 an an DT cord-005453-4057qib7 403 7 advanced advanced JJ cord-005453-4057qib7 403 8 liposomal liposomal IN cord-005453-4057qib7 403 9 encapsulation encapsulation NN cord-005453-4057qib7 403 10 of of IN cord-005453-4057qib7 403 11 cytarabine cytarabine NN cord-005453-4057qib7 403 12 / / SYM cord-005453-4057qib7 403 13 daunorubicin daunorubicin NNS cord-005453-4057qib7 403 14 at at IN cord-005453-4057qib7 403 15 a a DT cord-005453-4057qib7 403 16 synergistic synergistic JJ cord-005453-4057qib7 403 17 5:1 5:1 CD cord-005453-4057qib7 403 18 molar molar JJ cord-005453-4057qib7 403 19 ratio ratio NN cord-005453-4057qib7 403 20 . . . cord-005453-4057qib7 404 1 CPX-351 CPX-351 NNP cord-005453-4057qib7 404 2 is be VBZ cord-005453-4057qib7 404 3 approved approve VBN cord-005453-4057qib7 404 4 by by IN cord-005453-4057qib7 404 5 the the DT cord-005453-4057qib7 404 6 US US NNP cord-005453-4057qib7 404 7 FDA FDA NNP cord-005453-4057qib7 404 8 and and CC cord-005453-4057qib7 404 9 EMA EMA NNP cord-005453-4057qib7 404 10 for for IN cord-005453-4057qib7 404 11 the the DT cord-005453-4057qib7 404 12 treatment treatment NN cord-005453-4057qib7 404 13 of of IN cord-005453-4057qib7 404 14 adults adult NNS cord-005453-4057qib7 404 15 with with IN cord-005453-4057qib7 404 16 newly newly RB cord-005453-4057qib7 404 17 diagnosed diagnose VBN cord-005453-4057qib7 404 18 , , , cord-005453-4057qib7 404 19 therapy therapy NN cord-005453-4057qib7 404 20 - - HYPH cord-005453-4057qib7 404 21 related relate VBN cord-005453-4057qib7 404 22 AML AML NNP cord-005453-4057qib7 404 23 or or CC cord-005453-4057qib7 404 24 AML AML NNP cord-005453-4057qib7 404 25 with with IN cord-005453-4057qib7 404 26 myelodysplasia myelodysplasia NNP cord-005453-4057qib7 404 27 - - HYPH cord-005453-4057qib7 404 28 related relate VBN cord-005453-4057qib7 404 29 changes change NNS cord-005453-4057qib7 404 30 . . . cord-005453-4057qib7 405 1 Methods method NNS cord-005453-4057qib7 405 2 : : : cord-005453-4057qib7 405 3 Safety safety NN cord-005453-4057qib7 405 4 data datum NNS cord-005453-4057qib7 405 5 were be VBD cord-005453-4057qib7 405 6 pooled pool VBN cord-005453-4057qib7 405 7 from from IN cord-005453-4057qib7 405 8 5 5 CD cord-005453-4057qib7 405 9 studies study NNS cord-005453-4057qib7 405 10 of of IN cord-005453-4057qib7 405 11 CPX-351 cpx-351 NN cord-005453-4057qib7 405 12 in in IN cord-005453-4057qib7 405 13 adults adult NNS cord-005453-4057qib7 405 14 aged age VBN cord-005453-4057qib7 405 15 18 18 CD cord-005453-4057qib7 405 16 - - SYM cord-005453-4057qib7 405 17 75 75 CD cord-005453-4057qib7 405 18 years year NNS cord-005453-4057qib7 405 19 with with IN cord-005453-4057qib7 405 20 newly newly RB cord-005453-4057qib7 405 21 diagnosed diagnose VBN cord-005453-4057qib7 405 22 or or CC cord-005453-4057qib7 405 23 relapsed relapse VBN cord-005453-4057qib7 405 24 / / SYM cord-005453-4057qib7 405 25 refractory refractory JJ cord-005453-4057qib7 405 26 AML AML NNP cord-005453-4057qib7 405 27 . . . cord-005453-4057qib7 406 1 CPX-351 cpx-351 UH cord-005453-4057qib7 407 1 induction induction NN cord-005453-4057qib7 407 2 consisted consist VBD cord-005453-4057qib7 407 3 of of IN cord-005453-4057qib7 407 4 100 100 CD cord-005453-4057qib7 407 5 units unit NNS cord-005453-4057qib7 407 6 / / SYM cord-005453-4057qib7 407 7 m m NN cord-005453-4057qib7 407 8 2 2 CD cord-005453-4057qib7 407 9 ( ( -LRB- cord-005453-4057qib7 407 10 cytarabine cytarabine NNP cord-005453-4057qib7 407 11 100 100 CD cord-005453-4057qib7 407 12 mg mg NNP cord-005453-4057qib7 407 13 / / SYM cord-005453-4057qib7 407 14 m m NN cord-005453-4057qib7 407 15 2 2 CD cord-005453-4057qib7 408 1 + + CC cord-005453-4057qib7 408 2 daunorubicin daunorubicin NNS cord-005453-4057qib7 408 3 44 44 CD cord-005453-4057qib7 408 4 mg mg NNP cord-005453-4057qib7 408 5 / / SYM cord-005453-4057qib7 408 6 m m NNP cord-005453-4057qib7 408 7 2 2 CD cord-005453-4057qib7 408 8 ) ) -RRB- cord-005453-4057qib7 408 9 on on IN cord-005453-4057qib7 408 10 Days day NNS cord-005453-4057qib7 408 11 1 1 CD cord-005453-4057qib7 408 12 , , , cord-005453-4057qib7 408 13 3 3 CD cord-005453-4057qib7 408 14 , , , cord-005453-4057qib7 408 15 and and CC cord-005453-4057qib7 408 16 5 5 LS cord-005453-4057qib7 408 17 ( ( -LRB- cord-005453-4057qib7 408 18 second second JJ cord-005453-4057qib7 408 19 induction induction NN cord-005453-4057qib7 408 20 : : : cord-005453-4057qib7 408 21 Days day NNS cord-005453-4057qib7 408 22 1 1 CD cord-005453-4057qib7 408 23 and and CC cord-005453-4057qib7 408 24 3 3 CD cord-005453-4057qib7 408 25 ) ) -RRB- cord-005453-4057qib7 408 26 . . . cord-005453-4057qib7 409 1 CPX-351 CPX-351 NNP cord-005453-4057qib7 409 2 consolidation consolidation NN cord-005453-4057qib7 409 3 consisted consist VBD cord-005453-4057qib7 409 4 of of IN cord-005453-4057qib7 409 5 65 65 CD cord-005453-4057qib7 409 6 or or CC cord-005453-4057qib7 409 7 100 100 CD cord-005453-4057qib7 409 8 units unit NNS cord-005453-4057qib7 409 9 / / SYM cord-005453-4057qib7 409 10 m m NN cord-005453-4057qib7 409 11 2 2 CD cord-005453-4057qib7 409 12 ( ( -LRB- cord-005453-4057qib7 409 13 varying vary VBG cord-005453-4057qib7 409 14 by by IN cord-005453-4057qib7 409 15 study study NN cord-005453-4057qib7 409 16 ) ) -RRB- cord-005453-4057qib7 409 17 on on IN cord-005453-4057qib7 409 18 Days day NNS cord-005453-4057qib7 409 19 1 1 CD cord-005453-4057qib7 409 20 and and CC cord-005453-4057qib7 409 21 3 3 CD cord-005453-4057qib7 409 22 . . . cord-005453-4057qib7 410 1 CPX-351 CPX-351 NNP cord-005453-4057qib7 410 2 was be VBD cord-005453-4057qib7 410 3 evaluated evaluate VBN cord-005453-4057qib7 410 4 against against IN cord-005453-4057qib7 410 5 standard standard JJ cord-005453-4057qib7 410 6 - - HYPH cord-005453-4057qib7 410 7 of of IN cord-005453-4057qib7 410 8 - - HYPH cord-005453-4057qib7 410 9 care care NN cord-005453-4057qib7 410 10 controls control NNS cord-005453-4057qib7 410 11 . . . cord-005453-4057qib7 411 1 Results result NNS cord-005453-4057qib7 411 2 : : : cord-005453-4057qib7 412 1 Baseline baseline JJ cord-005453-4057qib7 412 2 characteristics characteristic NNS cord-005453-4057qib7 412 3 were be VBD cord-005453-4057qib7 412 4 generally generally RB cord-005453-4057qib7 412 5 balanced balance VBN cord-005453-4057qib7 412 6 between between IN cord-005453-4057qib7 412 7 CPX-351 cpx-351 NN cord-005453-4057qib7 412 8 ( ( -LRB- cord-005453-4057qib7 412 9 n=375 n=375 NNP cord-005453-4057qib7 412 10 ) ) -RRB- cord-005453-4057qib7 412 11 and and CC cord-005453-4057qib7 412 12 controls control NNS cord-005453-4057qib7 412 13 ( ( -LRB- cord-005453-4057qib7 412 14 n=236 n=236 UH cord-005453-4057qib7 412 15 ) ) -RRB- cord-005453-4057qib7 412 16 ; ; : cord-005453-4057qib7 412 17 the the DT cord-005453-4057qib7 412 18 majority majority NN cord-005453-4057qib7 412 19 of of IN cord-005453-4057qib7 412 20 patients patient NNS cord-005453-4057qib7 412 21 were be VBD cord-005453-4057qib7 412 22 aged age VBN cord-005453-4057qib7 412 23 ≥60 ≥60 JJ cord-005453-4057qib7 412 24 years year NNS cord-005453-4057qib7 412 25 ( ( -LRB- cord-005453-4057qib7 412 26 78 78 CD cord-005453-4057qib7 412 27 % % NN cord-005453-4057qib7 412 28 ; ; : cord-005453-4057qib7 412 29 87 87 CD cord-005453-4057qib7 412 30 % % NN cord-005453-4057qib7 412 31 ) ) -RRB- cord-005453-4057qib7 412 32 and and CC cord-005453-4057qib7 412 33 had have VBD cord-005453-4057qib7 412 34 secondary secondary JJ cord-005453-4057qib7 412 35 AML AML NNP cord-005453-4057qib7 412 36 ( ( -LRB- cord-005453-4057qib7 412 37 55 55 CD cord-005453-4057qib7 412 38 % % NN cord-005453-4057qib7 412 39 ; ; : cord-005453-4057qib7 412 40 72 72 CD cord-005453-4057qib7 412 41 % % NN cord-005453-4057qib7 412 42 ) ) -RRB- cord-005453-4057qib7 412 43 . . . cord-005453-4057qib7 413 1 Controls control NNS cord-005453-4057qib7 413 2 included include VBD cord-005453-4057qib7 413 3 7 7 CD cord-005453-4057qib7 413 4 + + SYM cord-005453-4057qib7 413 5 3 3 CD cord-005453-4057qib7 413 6 ( ( -LRB- cord-005453-4057qib7 413 7 n=192 n=192 NNP cord-005453-4057qib7 413 8 ) ) -RRB- cord-005453-4057qib7 413 9 and and CC cord-005453-4057qib7 413 10 salvage salvage VB cord-005453-4057qib7 413 11 therapy therapy NN cord-005453-4057qib7 413 12 with with IN cord-005453-4057qib7 413 13 mitoxantrone mitoxantrone NN cord-005453-4057qib7 413 14 / / SYM cord-005453-4057qib7 413 15 etoposide/ etoposide/ NNP cord-005453-4057qib7 413 16 cytarabine cytarabine RB cord-005453-4057qib7 414 1 ( ( -LRB- cord-005453-4057qib7 414 2 n=23 n=23 NNP cord-005453-4057qib7 414 3 ) ) -RRB- cord-005453-4057qib7 414 4 , , , cord-005453-4057qib7 414 5 idarubicin idarubicin NNP cord-005453-4057qib7 414 6 / / SYM cord-005453-4057qib7 414 7 cytarabine cytarabine NNP cord-005453-4057qib7 414 8 ( ( -LRB- cord-005453-4057qib7 414 9 n=8 n=8 NNP cord-005453-4057qib7 414 10 ) ) -RRB- cord-005453-4057qib7 414 11 , , , cord-005453-4057qib7 414 12 other other JJ cord-005453-4057qib7 414 13 cytarabine cytarabine NN cord-005453-4057qib7 414 14 - - HYPH cord-005453-4057qib7 414 15 based base VBN cord-005453-4057qib7 414 16 chemotherapy chemotherapy NN cord-005453-4057qib7 414 17 ( ( -LRB- cord-005453-4057qib7 414 18 n=12 n=12 NNP cord-005453-4057qib7 414 19 ) ) -RRB- cord-005453-4057qib7 414 20 , , , cord-005453-4057qib7 414 21 and and CC cord-005453-4057qib7 414 22 mitoxantrone/ mitoxantrone/ CD cord-005453-4057qib7 414 23 etoposide etoposide JJ cord-005453-4057qib7 414 24 ( ( -LRB- cord-005453-4057qib7 414 25 n=1 n=1 CD cord-005453-4057qib7 414 26 ) ) -RRB- cord-005453-4057qib7 414 27 . . . cord-005453-4057qib7 415 1 The the DT cord-005453-4057qib7 415 2 treatment treatment NN cord-005453-4057qib7 415 3 - - HYPH cord-005453-4057qib7 415 4 emergent emergent JJ cord-005453-4057qib7 415 5 adverse adverse JJ cord-005453-4057qib7 415 6 event event NN cord-005453-4057qib7 415 7 ( ( -LRB- cord-005453-4057qib7 415 8 TEAE TEAE NNP cord-005453-4057qib7 415 9 ) ) -RRB- cord-005453-4057qib7 415 10 profile profile NN cord-005453-4057qib7 415 11 of of IN cord-005453-4057qib7 415 12 CPX-351 CPX-351 NNP cord-005453-4057qib7 415 13 100 100 CD cord-005453-4057qib7 415 14 units unit NNS cord-005453-4057qib7 415 15 / / SYM cord-005453-4057qib7 415 16 m m NN cord-005453-4057qib7 415 17 2 2 CD cord-005453-4057qib7 415 18 was be VBD cord-005453-4057qib7 415 19 comparable comparable JJ cord-005453-4057qib7 415 20 to to IN cord-005453-4057qib7 415 21 induction induction NN cord-005453-4057qib7 415 22 controls control NNS cord-005453-4057qib7 415 23 , , , cord-005453-4057qib7 415 24 but but CC cord-005453-4057qib7 415 25 associated associate VBN cord-005453-4057qib7 415 26 with with IN cord-005453-4057qib7 415 27 a a DT cord-005453-4057qib7 415 28 greater great JJR cord-005453-4057qib7 415 29 proportion proportion NN cord-005453-4057qib7 415 30 of of IN cord-005453-4057qib7 415 31 patients patient NNS cord-005453-4057qib7 415 32 with with IN cord-005453-4057qib7 415 33 TEAEs teae NNS cord-005453-4057qib7 415 34 , , , cord-005453-4057qib7 415 35 grade grade NN cord-005453-4057qib7 415 36 ≥3 ≥3 NNP cord-005453-4057qib7 415 37 TEAEs TEAEs NNPS cord-005453-4057qib7 415 38 , , , cord-005453-4057qib7 415 39 and and CC cord-005453-4057qib7 415 40 serious serious JJ cord-005453-4057qib7 415 41 TEAEs teae NNS cord-005453-4057qib7 415 42 during during IN cord-005453-4057qib7 415 43 consolidation consolidation NN cord-005453-4057qib7 415 44 ( ( -LRB- cord-005453-4057qib7 415 45 Table table NN cord-005453-4057qib7 415 46 ) ) -RRB- cord-005453-4057qib7 415 47 . . . cord-005453-4057qib7 416 1 Therefore therefore RB cord-005453-4057qib7 416 2 , , , cord-005453-4057qib7 416 3 the the DT cord-005453-4057qib7 416 4 CPX-351 cpx-351 NN cord-005453-4057qib7 416 5 consolidation consolidation NN cord-005453-4057qib7 416 6 dose dose NN cord-005453-4057qib7 416 7 was be VBD cord-005453-4057qib7 416 8 reduced reduce VBN cord-005453-4057qib7 416 9 to to IN cord-005453-4057qib7 416 10 65 65 CD cord-005453-4057qib7 416 11 units unit NNS cord-005453-4057qib7 416 12 / / SYM cord-005453-4057qib7 416 13 m m CD cord-005453-4057qib7 416 14 2 2 CD cord-005453-4057qib7 416 15 in in IN cord-005453-4057qib7 416 16 latter latter JJ cord-005453-4057qib7 416 17 studies study NNS cord-005453-4057qib7 416 18 ; ; : cord-005453-4057qib7 416 19 this this DT cord-005453-4057qib7 416 20 dose dose NN cord-005453-4057qib7 416 21 demonstrated demonstrate VBD cord-005453-4057qib7 416 22 an an DT cord-005453-4057qib7 416 23 improved improve VBN cord-005453-4057qib7 416 24 TEAE TEAE NNP cord-005453-4057qib7 416 25 profile profile NN cord-005453-4057qib7 416 26 similar similar JJ cord-005453-4057qib7 416 27 to to IN cord-005453-4057qib7 416 28 consolidation consolidation NN cord-005453-4057qib7 416 29 controls control NNS cord-005453-4057qib7 416 30 . . . cord-005453-4057qib7 417 1 The the DT cord-005453-4057qib7 417 2 most most RBS cord-005453-4057qib7 417 3 frequent frequent JJ cord-005453-4057qib7 417 4 system system NN cord-005453-4057qib7 417 5 organ organ NN cord-005453-4057qib7 417 6 class class NN cord-005453-4057qib7 417 7 was be VBD cord-005453-4057qib7 417 8 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 417 9 disorders disorder NNS cord-005453-4057qib7 417 10 for for IN cord-005453-4057qib7 417 11 both both CC cord-005453-4057qib7 417 12 CPX-351 cpx-351 NN cord-005453-4057qib7 417 13 and and CC cord-005453-4057qib7 417 14 controls control NNS cord-005453-4057qib7 417 15 ; ; : cord-005453-4057qib7 417 16 a a DT cord-005453-4057qib7 417 17 lower low JJR cord-005453-4057qib7 417 18 incidence incidence NN cord-005453-4057qib7 417 19 was be VBD cord-005453-4057qib7 417 20 reported report VBN cord-005453-4057qib7 417 21 for for IN cord-005453-4057qib7 417 22 CPX-351 cpx-351 NN cord-005453-4057qib7 417 23 ( ( -LRB- cord-005453-4057qib7 417 24 90 90 CD cord-005453-4057qib7 417 25 % % NN cord-005453-4057qib7 417 26 ) ) -RRB- cord-005453-4057qib7 417 27 versus versus IN cord-005453-4057qib7 417 28 controls control NNS cord-005453-4057qib7 417 29 ( ( -LRB- cord-005453-4057qib7 417 30 95 95 CD cord-005453-4057qib7 417 31 % % NN cord-005453-4057qib7 417 32 ) ) -RRB- cord-005453-4057qib7 417 33 , , , cord-005453-4057qib7 417 34 with with IN cord-005453-4057qib7 417 35 this this DT cord-005453-4057qib7 417 36 difference difference NN cord-005453-4057qib7 417 37 driven drive VBN cord-005453-4057qib7 417 38 by by IN cord-005453-4057qib7 417 39 the the DT cord-005453-4057qib7 417 40 lower low JJR cord-005453-4057qib7 417 41 incidence incidence NN cord-005453-4057qib7 417 42 of of IN cord-005453-4057qib7 417 43 diarrhea diarrhea NN cord-005453-4057qib7 417 44 for for IN cord-005453-4057qib7 417 45 CPX-351 cpx-351 NN cord-005453-4057qib7 417 46 ( ( -LRB- cord-005453-4057qib7 417 47 46 46 CD cord-005453-4057qib7 417 48 % % NN cord-005453-4057qib7 417 49 ) ) -RRB- cord-005453-4057qib7 417 50 versus versus IN cord-005453-4057qib7 417 51 controls control NNS cord-005453-4057qib7 417 52 ( ( -LRB- cord-005453-4057qib7 417 53 66 66 CD cord-005453-4057qib7 417 54 % % NN cord-005453-4057qib7 417 55 ) ) -RRB- cord-005453-4057qib7 417 56 . . . cord-005453-4057qib7 418 1 The the DT cord-005453-4057qib7 418 2 most most RBS cord-005453-4057qib7 418 3 frequently frequently RB cord-005453-4057qib7 418 4 reported report VBN cord-005453-4057qib7 418 5 grade grade NN cord-005453-4057qib7 418 6 ≥3 ≥3 NNP cord-005453-4057qib7 418 7 TEAEs teae NNS cord-005453-4057qib7 418 8 were be VBD cord-005453-4057qib7 418 9 febrile febrile JJ cord-005453-4057qib7 418 10 neutropenia neutropenia NN cord-005453-4057qib7 419 1 ( ( -LRB- cord-005453-4057qib7 419 2 CPX-351 cpx-351 NN cord-005453-4057qib7 419 3 : : : cord-005453-4057qib7 419 4 62 62 CD cord-005453-4057qib7 419 5 % % NN cord-005453-4057qib7 419 6 ; ; , cord-005453-4057qib7 419 7 controls control NNS cord-005453-4057qib7 419 8 : : : cord-005453-4057qib7 419 9 59 59 CD cord-005453-4057qib7 419 10 % % NN cord-005453-4057qib7 419 11 ) ) -RRB- cord-005453-4057qib7 419 12 , , , cord-005453-4057qib7 419 13 pneumonia pneumonia NN cord-005453-4057qib7 419 14 ( ( -LRB- cord-005453-4057qib7 419 15 16 16 CD cord-005453-4057qib7 419 16 % % NN cord-005453-4057qib7 419 17 ; ; : cord-005453-4057qib7 419 18 13 13 CD cord-005453-4057qib7 419 19 % % NN cord-005453-4057qib7 419 20 ) ) -RRB- cord-005453-4057qib7 419 21 , , , cord-005453-4057qib7 419 22 hypoxia hypoxia NN cord-005453-4057qib7 419 23 ( ( -LRB- cord-005453-4057qib7 419 24 10 10 CD cord-005453-4057qib7 419 25 % % NN cord-005453-4057qib7 419 26 ; ; : cord-005453-4057qib7 419 27 11 11 CD cord-005453-4057qib7 419 28 % % NN cord-005453-4057qib7 419 29 ) ) -RRB- cord-005453-4057qib7 419 30 , , , cord-005453-4057qib7 419 31 and and CC cord-005453-4057qib7 419 32 bacteremia bacteremia NN cord-005453-4057qib7 419 33 ( ( -LRB- cord-005453-4057qib7 419 34 10 10 CD cord-005453-4057qib7 419 35 % % NN cord-005453-4057qib7 419 36 ; ; : cord-005453-4057qib7 419 37 3 3 CD cord-005453-4057qib7 419 38 % % NN cord-005453-4057qib7 419 39 ) ) -RRB- cord-005453-4057qib7 419 40 . . . cord-005453-4057qib7 420 1 Early early JJ cord-005453-4057qib7 420 2 mortality mortality NN cord-005453-4057qib7 420 3 rates rate NNS cord-005453-4057qib7 420 4 , , , cord-005453-4057qib7 420 5 both both DT cord-005453-4057qib7 420 6 overall overall JJ cord-005453-4057qib7 420 7 and and CC cord-005453-4057qib7 420 8 by by IN cord-005453-4057qib7 420 9 treatment treatment NN cord-005453-4057qib7 420 10 period period NN cord-005453-4057qib7 420 11 , , , cord-005453-4057qib7 420 12 appeared appear VBD cord-005453-4057qib7 420 13 lower lower RBR cord-005453-4057qib7 420 14 with with IN cord-005453-4057qib7 421 1 CPX-351 cpx-351 RB cord-005453-4057qib7 421 2 versus versus IN cord-005453-4057qib7 421 3 controls control NNS cord-005453-4057qib7 421 4 at at IN cord-005453-4057qib7 421 5 Day day NN cord-005453-4057qib7 421 6 30 30 CD cord-005453-4057qib7 421 7 and and CC cord-005453-4057qib7 421 8 Day day NN cord-005453-4057qib7 421 9 60 60 CD cord-005453-4057qib7 421 10 ( ( -LRB- cord-005453-4057qib7 421 11 Table table NN cord-005453-4057qib7 421 12 ) ) -RRB- cord-005453-4057qib7 421 13 ; ; : cord-005453-4057qib7 421 14 the the DT cord-005453-4057qib7 421 15 majority majority NN cord-005453-4057qib7 421 16 of of IN cord-005453-4057qib7 421 17 early early JJ cord-005453-4057qib7 421 18 deaths death NNS cord-005453-4057qib7 421 19 were be VBD cord-005453-4057qib7 421 20 attributable attributable JJ cord-005453-4057qib7 421 21 to to IN cord-005453-4057qib7 421 22 TEAEs teae NNS cord-005453-4057qib7 421 23 . . . cord-005453-4057qib7 422 1 Conclusions conclusion NNS cord-005453-4057qib7 422 2 : : : cord-005453-4057qib7 423 1 Across across IN cord-005453-4057qib7 423 2 the the DT cord-005453-4057qib7 423 3 5 5 CD cord-005453-4057qib7 423 4 studies study NNS cord-005453-4057qib7 423 5 comprising comprise VBG cord-005453-4057qib7 423 6 the the DT cord-005453-4057qib7 423 7 CPX-351 CPX-351 NNP cord-005453-4057qib7 423 8 clinical clinical JJ cord-005453-4057qib7 423 9 development development NN cord-005453-4057qib7 423 10 program program NN cord-005453-4057qib7 423 11 , , , cord-005453-4057qib7 423 12 CPX-351 CPX-351 NNP cord-005453-4057qib7 423 13 demonstrated demonstrate VBD cord-005453-4057qib7 423 14 a a DT cord-005453-4057qib7 423 15 safety safety NN cord-005453-4057qib7 423 16 profile profile NN cord-005453-4057qib7 423 17 comparable comparable JJ cord-005453-4057qib7 423 18 to to IN cord-005453-4057qib7 423 19 conventional conventional JJ cord-005453-4057qib7 423 20 chemotherapy chemotherapy NN cord-005453-4057qib7 423 21 in in IN cord-005453-4057qib7 423 22 adults adult NNS cord-005453-4057qib7 423 23 with with IN cord-005453-4057qib7 423 24 newly newly RB cord-005453-4057qib7 423 25 diagnosed diagnose VBN cord-005453-4057qib7 423 26 or or CC cord-005453-4057qib7 423 27 relapsed relapse VBN cord-005453-4057qib7 423 28 / / SYM cord-005453-4057qib7 423 29 refractory refractory JJ cord-005453-4057qib7 423 30 AML AML NNP cord-005453-4057qib7 423 31 . . . cord-005453-4057qib7 424 1 Background background NN cord-005453-4057qib7 424 2 : : : cord-005453-4057qib7 425 1 Haploidentical Haploidentical NNP cord-005453-4057qib7 425 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 425 3 stem stem NN cord-005453-4057qib7 425 4 cell cell NN cord-005453-4057qib7 425 5 transplantation transplantation NN cord-005453-4057qib7 425 6 ( ( -LRB- cord-005453-4057qib7 425 7 HSCT HSCT NNP cord-005453-4057qib7 425 8 ) ) -RRB- cord-005453-4057qib7 425 9 with with IN cord-005453-4057qib7 425 10 post post JJ cord-005453-4057qib7 425 11 - - JJ cord-005453-4057qib7 425 12 transplantation transplantation JJ cord-005453-4057qib7 425 13 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 425 14 ( ( -LRB- cord-005453-4057qib7 425 15 PGCY PGCY NNP cord-005453-4057qib7 425 16 ) ) -RRB- cord-005453-4057qib7 425 17 marked mark VBD cord-005453-4057qib7 425 18 improved improved JJ cord-005453-4057qib7 425 19 clinical clinical JJ cord-005453-4057qib7 425 20 outcome outcome NN cord-005453-4057qib7 425 21 . . . cord-005453-4057qib7 426 1 Recent recent JJ cord-005453-4057qib7 426 2 studies study NNS cord-005453-4057qib7 426 3 comparing compare VBG cord-005453-4057qib7 426 4 allogeneic allogeneic JJ cord-005453-4057qib7 426 5 HSCT HSCT NNP cord-005453-4057qib7 426 6 using use VBG cord-005453-4057qib7 426 7 unrelated unrelated JJ cord-005453-4057qib7 426 8 donors donor NNS cord-005453-4057qib7 426 9 versus versus IN cord-005453-4057qib7 426 10 haplo haplo NNP cord-005453-4057qib7 426 11 donors donor NNS cord-005453-4057qib7 426 12 in in IN cord-005453-4057qib7 426 13 patients patient NNS cord-005453-4057qib7 426 14 with with IN cord-005453-4057qib7 426 15 acute acute JJ cord-005453-4057qib7 426 16 leukemia leukemia NN cord-005453-4057qib7 426 17 have have VBP cord-005453-4057qib7 426 18 suggested suggest VBN cord-005453-4057qib7 426 19 equivalent equivalent JJ cord-005453-4057qib7 426 20 outcomes outcome NNS cord-005453-4057qib7 426 21 . . . cord-005453-4057qib7 427 1 The the DT cord-005453-4057qib7 427 2 depletion depletion NN cord-005453-4057qib7 427 3 of of IN cord-005453-4057qib7 427 4 Tcells Tcells NNP cord-005453-4057qib7 427 5 with with IN cord-005453-4057qib7 427 6 PGCY PGCY NNP cord-005453-4057qib7 427 7 was be VBD cord-005453-4057qib7 427 8 subsequently subsequently RB cord-005453-4057qib7 427 9 applied apply VBN cord-005453-4057qib7 427 10 for for IN cord-005453-4057qib7 427 11 unrelated unrelated JJ cord-005453-4057qib7 427 12 HSCT HSCT NNP cord-005453-4057qib7 427 13 setting set VBG cord-005453-4057qib7 427 14 for for IN cord-005453-4057qib7 427 15 patients patient NNS cord-005453-4057qib7 427 16 with with IN cord-005453-4057qib7 427 17 unrelated unrelated JJ cord-005453-4057qib7 427 18 donor donor NN cord-005453-4057qib7 427 19 . . . cord-005453-4057qib7 428 1 Methods method NNS cord-005453-4057qib7 428 2 : : : cord-005453-4057qib7 428 3 We -PRON- PRP cord-005453-4057qib7 428 4 performed perform VBD cord-005453-4057qib7 428 5 a a DT cord-005453-4057qib7 428 6 retrospective retrospective JJ cord-005453-4057qib7 428 7 study study NN cord-005453-4057qib7 428 8 on on IN cord-005453-4057qib7 428 9 90 90 CD cord-005453-4057qib7 428 10 patients patient NNS cord-005453-4057qib7 428 11 with with IN cord-005453-4057qib7 428 12 acute acute JJ cord-005453-4057qib7 428 13 leukemia leukemia NN cord-005453-4057qib7 428 14 in in IN cord-005453-4057qib7 428 15 order order NN cord-005453-4057qib7 428 16 to to TO cord-005453-4057qib7 428 17 compare compare VB cord-005453-4057qib7 428 18 the the DT cord-005453-4057qib7 428 19 outcome outcome NN cord-005453-4057qib7 428 20 after after IN cord-005453-4057qib7 428 21 HLA HLA NNP cord-005453-4057qib7 428 22 haploidentical haploidentical NNP cord-005453-4057qib7 428 23 ( ( -LRB- cord-005453-4057qib7 428 24 n=30 n=30 NNP cord-005453-4057qib7 428 25 ) ) -RRB- cord-005453-4057qib7 428 26 and and CC cord-005453-4057qib7 428 27 unrelated unrelated JJ cord-005453-4057qib7 428 28 HSCT HSCT NNP cord-005453-4057qib7 428 29 ( ( -LRB- cord-005453-4057qib7 428 30 n=60 n=60 JJ cord-005453-4057qib7 428 31 ) ) -RRB- cord-005453-4057qib7 428 32 with with IN cord-005453-4057qib7 428 33 PGCY PGCY NNP cord-005453-4057qib7 428 34 . . . cord-005453-4057qib7 429 1 The the DT cord-005453-4057qib7 429 2 main main JJ cord-005453-4057qib7 429 3 characteristics characteristic NNS cord-005453-4057qib7 429 4 of of IN cord-005453-4057qib7 429 5 patients patient NNS cord-005453-4057qib7 429 6 were be VBD cord-005453-4057qib7 429 7 similar similar JJ cord-005453-4057qib7 429 8 in in IN cord-005453-4057qib7 429 9 both both DT cord-005453-4057qib7 429 10 groups group NNS cord-005453-4057qib7 429 11 . . . cord-005453-4057qib7 430 1 Baseline baseline JJ cord-005453-4057qib7 430 2 disease disease NN cord-005453-4057qib7 430 3 were be VBD cord-005453-4057qib7 430 4 : : : cord-005453-4057qib7 430 5 19 19 CD cord-005453-4057qib7 430 6 AML AML NNP cord-005453-4057qib7 430 7 ( ( -LRB- cord-005453-4057qib7 430 8 63 63 CD cord-005453-4057qib7 430 9 % % NN cord-005453-4057qib7 430 10 ) ) -RRB- cord-005453-4057qib7 430 11 and and CC cord-005453-4057qib7 430 12 11 11 CD cord-005453-4057qib7 430 13 ALL all DT cord-005453-4057qib7 430 14 ( ( -LRB- cord-005453-4057qib7 430 15 37 37 CD cord-005453-4057qib7 430 16 % % NN cord-005453-4057qib7 430 17 ) ) -RRB- cord-005453-4057qib7 430 18 for for IN cord-005453-4057qib7 430 19 Haplo Haplo NNP cord-005453-4057qib7 430 20 group group NN cord-005453-4057qib7 430 21 and and CC cord-005453-4057qib7 430 22 33 33 CD cord-005453-4057qib7 430 23 AML AML NNP cord-005453-4057qib7 430 24 ( ( -LRB- cord-005453-4057qib7 430 25 55 55 CD cord-005453-4057qib7 430 26 % % NN cord-005453-4057qib7 430 27 ) ) -RRB- cord-005453-4057qib7 430 28 and and CC cord-005453-4057qib7 430 29 27 27 CD cord-005453-4057qib7 430 30 ALL all DT cord-005453-4057qib7 430 31 ( ( -LRB- cord-005453-4057qib7 430 32 45 45 CD cord-005453-4057qib7 430 33 % % NN cord-005453-4057qib7 430 34 ) ) -RRB- cord-005453-4057qib7 430 35 for for IN cord-005453-4057qib7 430 36 unrelated unrelated JJ cord-005453-4057qib7 430 37 group group NN cord-005453-4057qib7 430 38 . . . cord-005453-4057qib7 431 1 Disease Disease NNP cord-005453-4057qib7 431 2 state state NN cord-005453-4057qib7 431 3 at at IN cord-005453-4057qib7 431 4 time time NN cord-005453-4057qib7 431 5 of of IN cord-005453-4057qib7 431 6 haplo haplo NN cord-005453-4057qib7 431 7 and and CC cord-005453-4057qib7 431 8 unrelated unrelated JJ cord-005453-4057qib7 431 9 - - HYPH cord-005453-4057qib7 431 10 HSCT HSCT NNP cord-005453-4057qib7 431 11 were be VBD cord-005453-4057qib7 431 12 following follow VBG cord-005453-4057qib7 431 13 : : : cord-005453-4057qib7 431 14 19 19 CD cord-005453-4057qib7 431 15 and and CC cord-005453-4057qib7 431 16 50 50 CD cord-005453-4057qib7 431 17 patients patient NNS cord-005453-4057qib7 431 18 in in IN cord-005453-4057qib7 431 19 CR1 CR1 NNP cord-005453-4057qib7 431 20 ( ( -LRB- cord-005453-4057qib7 431 21 63 63 CD cord-005453-4057qib7 431 22 % % NN cord-005453-4057qib7 431 23 and and CC cord-005453-4057qib7 431 24 83 83 CD cord-005453-4057qib7 431 25 % % NN cord-005453-4057qib7 431 26 ) ) -RRB- cord-005453-4057qib7 431 27 and and CC cord-005453-4057qib7 431 28 11 11 CD cord-005453-4057qib7 431 29 and and CC cord-005453-4057qib7 431 30 10 10 CD cord-005453-4057qib7 431 31 non non JJ cord-005453-4057qib7 431 32 CR1 CR1 NNP cord-005453-4057qib7 431 33 ( ( -LRB- cord-005453-4057qib7 431 34 37 37 CD cord-005453-4057qib7 431 35 % % NN cord-005453-4057qib7 431 36 and and CC cord-005453-4057qib7 431 37 17 17 CD cord-005453-4057qib7 431 38 % % NN cord-005453-4057qib7 431 39 ) ) -RRB- cord-005453-4057qib7 431 40 . . . cord-005453-4057qib7 432 1 For for IN cord-005453-4057qib7 432 2 AML AML NNP cord-005453-4057qib7 432 3 recipients recipient NNS cord-005453-4057qib7 432 4 mainly mainly RB cord-005453-4057qib7 432 5 received receive VBD cord-005453-4057qib7 432 6 thiotepa thiotepa NNS cord-005453-4057qib7 432 7 , , , cord-005453-4057qib7 432 8 busulfan busulfan NN cord-005453-4057qib7 432 9 and and CC cord-005453-4057qib7 432 10 fludarabine fludarabine NN cord-005453-4057qib7 432 11 and and CC cord-005453-4057qib7 432 12 for for IN cord-005453-4057qib7 432 13 ALL all DT cord-005453-4057qib7 432 14 recipients recipient NNS cord-005453-4057qib7 432 15 received receive VBD cord-005453-4057qib7 432 16 TBI TBI NNP cord-005453-4057qib7 432 17 and and CC cord-005453-4057qib7 432 18 Etoposide Etoposide NNP cord-005453-4057qib7 432 19 conditioning conditioning NN cord-005453-4057qib7 432 20 . . . cord-005453-4057qib7 433 1 All all DT cord-005453-4057qib7 433 2 patients patient NNS cord-005453-4057qib7 433 3 who who WP cord-005453-4057qib7 433 4 received receive VBD cord-005453-4057qib7 433 5 PBSC PBSC NNP cord-005453-4057qib7 433 6 graft graft NN cord-005453-4057qib7 433 7 were be VBD cord-005453-4057qib7 433 8 treated treat VBN cord-005453-4057qib7 433 9 with with IN cord-005453-4057qib7 433 10 rabbit rabbit NN cord-005453-4057qib7 433 11 antithymocyte antithymocyte NNP cord-005453-4057qib7 433 12 globulin globulin NN cord-005453-4057qib7 433 13 ( ( -LRB- cord-005453-4057qib7 433 14 ATG ATG NNP cord-005453-4057qib7 433 15 ) ) -RRB- cord-005453-4057qib7 433 16 on on IN cord-005453-4057qib7 433 17 days day NNS cord-005453-4057qib7 433 18 -2 -2 XX cord-005453-4057qib7 434 1 and and CC cord-005453-4057qib7 434 2 -1 -1 NN cord-005453-4057qib7 434 3 . . . cord-005453-4057qib7 435 1 Results result NNS cord-005453-4057qib7 435 2 : : : cord-005453-4057qib7 436 1 At at IN cord-005453-4057qib7 436 2 the the DT cord-005453-4057qib7 436 3 time time NN cord-005453-4057qib7 436 4 of of IN cord-005453-4057qib7 436 5 analysis analysis NN cord-005453-4057qib7 436 6 , , , cord-005453-4057qib7 436 7 the the DT cord-005453-4057qib7 436 8 OS OS NNP cord-005453-4057qib7 436 9 and and CC cord-005453-4057qib7 436 10 DFS DFS NNP cord-005453-4057qib7 436 11 did do VBD cord-005453-4057qib7 436 12 not not RB cord-005453-4057qib7 436 13 differ differ VB cord-005453-4057qib7 436 14 between between IN cord-005453-4057qib7 436 15 the the DT cord-005453-4057qib7 436 16 Haplo Haplo NNP cord-005453-4057qib7 436 17 and and CC cord-005453-4057qib7 436 18 unrelated unrelated JJ cord-005453-4057qib7 436 19 groups group NNS cord-005453-4057qib7 436 20 ( ( -LRB- cord-005453-4057qib7 436 21 67 67 CD cord-005453-4057qib7 436 22 % % NN cord-005453-4057qib7 436 23 vs vs IN cord-005453-4057qib7 436 24 63 63 CD cord-005453-4057qib7 436 25 % % NN cord-005453-4057qib7 436 26 , , , cord-005453-4057qib7 436 27 and and CC cord-005453-4057qib7 436 28 63 63 CD cord-005453-4057qib7 436 29 % % NN cord-005453-4057qib7 436 30 vs vs IN cord-005453-4057qib7 436 31 56 56 CD cord-005453-4057qib7 436 32 % % NN cord-005453-4057qib7 436 33 ) ) -RRB- cord-005453-4057qib7 436 34 . . . cord-005453-4057qib7 437 1 Incidence incidence NN cord-005453-4057qib7 437 2 of of IN cord-005453-4057qib7 437 3 severe severe JJ cord-005453-4057qib7 437 4 ( ( -LRB- cord-005453-4057qib7 437 5 grade grade NN cord-005453-4057qib7 437 6 [ [ -LRB- cord-005453-4057qib7 437 7 3 3 CD cord-005453-4057qib7 437 8 ] ] -RRB- cord-005453-4057qib7 437 9 [ [ -LRB- cord-005453-4057qib7 437 10 4 4 CD cord-005453-4057qib7 437 11 ] ] -RRB- cord-005453-4057qib7 437 12 acute acute JJ cord-005453-4057qib7 437 13 GVHD GVHD NNP cord-005453-4057qib7 437 14 was be VBD cord-005453-4057qib7 437 15 the the DT cord-005453-4057qib7 437 16 same same JJ cord-005453-4057qib7 437 17 in in IN cord-005453-4057qib7 437 18 two two CD cord-005453-4057qib7 437 19 groups group NNS cord-005453-4057qib7 437 20 ( ( -LRB- cord-005453-4057qib7 437 21 10 10 CD cord-005453-4057qib7 437 22 % % NN cord-005453-4057qib7 437 23 versus versus IN cord-005453-4057qib7 437 24 8 8 CD cord-005453-4057qib7 437 25 % % NN cord-005453-4057qib7 437 26 ) ) -RRB- cord-005453-4057qib7 437 27 . . . cord-005453-4057qib7 438 1 Recipients recipient NNS cord-005453-4057qib7 438 2 of of IN cord-005453-4057qib7 438 3 Haplo Haplo NNP cord-005453-4057qib7 438 4 - - HYPH cord-005453-4057qib7 438 5 HSCT HSCT NNP cord-005453-4057qib7 438 6 transplant transplant NN cord-005453-4057qib7 438 7 were be VBD cord-005453-4057qib7 438 8 statistical statistical JJ cord-005453-4057qib7 438 9 significance significance NN cord-005453-4057qib7 438 10 less less RBR cord-005453-4057qib7 438 11 likely likely JJ cord-005453-4057qib7 438 12 to to TO cord-005453-4057qib7 438 13 experience experience VB cord-005453-4057qib7 438 14 disease disease NN cord-005453-4057qib7 438 15 relapse relapse NN cord-005453-4057qib7 438 16 ( ( -LRB- cord-005453-4057qib7 438 17 3 3 CD cord-005453-4057qib7 438 18 % % NN cord-005453-4057qib7 438 19 vs vs IN cord-005453-4057qib7 438 20 28 28 CD cord-005453-4057qib7 438 21 % % NN cord-005453-4057qib7 438 22 ) ) -RRB- cord-005453-4057qib7 438 23 and and CC cord-005453-4057qib7 438 24 chronic chronic JJ cord-005453-4057qib7 438 25 GVHD GVHD NNP cord-005453-4057qib7 438 26 ( ( -LRB- cord-005453-4057qib7 438 27 20 20 CD cord-005453-4057qib7 438 28 % % NN cord-005453-4057qib7 438 29 vs vs IN cord-005453-4057qib7 438 30 47,5 47,5 CD cord-005453-4057qib7 438 31 % % NN cord-005453-4057qib7 438 32 ) ) -RRB- cord-005453-4057qib7 438 33 . . . cord-005453-4057qib7 439 1 However however RB cord-005453-4057qib7 439 2 , , , cord-005453-4057qib7 439 3 GVHD GVHD NNP cord-005453-4057qib7 439 4 free free JJ cord-005453-4057qib7 439 5 relapse relapse NN cord-005453-4057qib7 439 6 free free JJ cord-005453-4057qib7 439 7 survival survival NN cord-005453-4057qib7 440 1 ( ( -LRB- cord-005453-4057qib7 440 2 GRFS GRFS NNP cord-005453-4057qib7 440 3 ) ) -RRB- cord-005453-4057qib7 440 4 rate rate NN cord-005453-4057qib7 440 5 was be VBD cord-005453-4057qib7 440 6 slightly slightly RB cord-005453-4057qib7 440 7 higher high JJR cord-005453-4057qib7 440 8 after after IN cord-005453-4057qib7 440 9 Haplo Haplo NNP cord-005453-4057qib7 440 10 - - HYPH cord-005453-4057qib7 440 11 HSCT HSCT NNP cord-005453-4057qib7 440 12 ( ( -LRB- cord-005453-4057qib7 440 13 77 77 CD cord-005453-4057qib7 440 14 % % NN cord-005453-4057qib7 440 15 vs vs IN cord-005453-4057qib7 440 16 64 64 CD cord-005453-4057qib7 440 17 % % NN cord-005453-4057qib7 440 18 ) ) -RRB- cord-005453-4057qib7 440 19 . . . cord-005453-4057qib7 441 1 Addition addition NN cord-005453-4057qib7 441 2 , , , cord-005453-4057qib7 441 3 cumulative cumulative JJ cord-005453-4057qib7 441 4 incidence incidence NN cord-005453-4057qib7 441 5 of of IN cord-005453-4057qib7 441 6 TRM TRM NNP cord-005453-4057qib7 441 7 rate rate NN cord-005453-4057qib7 441 8 was be VBD cord-005453-4057qib7 441 9 higher high JJR cord-005453-4057qib7 441 10 after after IN cord-005453-4057qib7 441 11 Haplo Haplo NNP cord-005453-4057qib7 441 12 - - HYPH cord-005453-4057qib7 441 13 HSCT HSCT NNP cord-005453-4057qib7 441 14 ( ( -LRB- cord-005453-4057qib7 441 15 30 30 CD cord-005453-4057qib7 441 16 % % NN cord-005453-4057qib7 441 17 vs vs IN cord-005453-4057qib7 441 18 15%).For 15%).for CD cord-005453-4057qib7 441 19 Haplo Haplo NNP cord-005453-4057qib7 441 20 and and CC cord-005453-4057qib7 441 21 unrelated unrelated JJ cord-005453-4057qib7 441 22 groups group NNS cord-005453-4057qib7 441 23 who who WP cord-005453-4057qib7 441 24 underwent undergo VBD cord-005453-4057qib7 441 25 HSCT HSCT NNP cord-005453-4057qib7 441 26 in in IN cord-005453-4057qib7 441 27 CR1 CR1 NNP cord-005453-4057qib7 441 28 , , , cord-005453-4057qib7 441 29 the the DT cord-005453-4057qib7 441 30 OS OS NNP cord-005453-4057qib7 441 31 were be VBD cord-005453-4057qib7 441 32 84 84 CD cord-005453-4057qib7 441 33 % % NN cord-005453-4057qib7 441 34 and and CC cord-005453-4057qib7 441 35 67 67 CD cord-005453-4057qib7 441 36 % % NN cord-005453-4057qib7 441 37 versus versus IN cord-005453-4057qib7 441 38 22 22 CD cord-005453-4057qib7 441 39 % % NN cord-005453-4057qib7 441 40 and and CC cord-005453-4057qib7 441 41 45 45 CD cord-005453-4057qib7 441 42 % % NN cord-005453-4057qib7 441 43 for for IN cord-005453-4057qib7 441 44 those those DT cord-005453-4057qib7 441 45 in in IN cord-005453-4057qib7 441 46 non non JJ cord-005453-4057qib7 441 47 CR1 CR1 NNP cord-005453-4057qib7 441 48 . . . cord-005453-4057qib7 442 1 For for IN cord-005453-4057qib7 442 2 AML AML NNP cord-005453-4057qib7 442 3 , , , cord-005453-4057qib7 442 4 the the DT cord-005453-4057qib7 442 5 OS OS NNP cord-005453-4057qib7 442 6 was be VBD cord-005453-4057qib7 442 7 same same JJ cord-005453-4057qib7 442 8 in in IN cord-005453-4057qib7 442 9 two two CD cord-005453-4057qib7 442 10 groups group NNS cord-005453-4057qib7 442 11 ( ( -LRB- cord-005453-4057qib7 442 12 Haplo Haplo NNP cord-005453-4057qib7 442 13 63 63 CD cord-005453-4057qib7 442 14 % % NN cord-005453-4057qib7 442 15 versus versus IN cord-005453-4057qib7 442 16 unrelated unrelated JJ cord-005453-4057qib7 442 17 67 67 CD cord-005453-4057qib7 442 18 % % NN cord-005453-4057qib7 442 19 ) ) -RRB- cord-005453-4057qib7 442 20 . . . cord-005453-4057qib7 443 1 However however RB cord-005453-4057qib7 443 2 patients patient NNS cord-005453-4057qib7 443 3 with with IN cord-005453-4057qib7 443 4 ALL all DT cord-005453-4057qib7 443 5 , , , cord-005453-4057qib7 443 6 the the DT cord-005453-4057qib7 443 7 OS OS NNP cord-005453-4057qib7 443 8 was be VBD cord-005453-4057qib7 443 9 higher high JJR cord-005453-4057qib7 443 10 in in IN cord-005453-4057qib7 443 11 Haplo Haplo NNP cord-005453-4057qib7 443 12 group group NN cord-005453-4057qib7 443 13 compared compare VBN cord-005453-4057qib7 443 14 with with IN cord-005453-4057qib7 443 15 unrelated unrelated JJ cord-005453-4057qib7 443 16 group group NN cord-005453-4057qib7 443 17 ( ( -LRB- cord-005453-4057qib7 443 18 72 72 CD cord-005453-4057qib7 443 19 % % NN cord-005453-4057qib7 443 20 versus versus IN cord-005453-4057qib7 443 21 59 59 CD cord-005453-4057qib7 443 22 % % NN cord-005453-4057qib7 443 23 ) ) -RRB- cord-005453-4057qib7 443 24 . . . cord-005453-4057qib7 444 1 The the DT cord-005453-4057qib7 444 2 impact impact NN cord-005453-4057qib7 444 3 of of IN cord-005453-4057qib7 444 4 pretransplant pretransplant JJ cord-005453-4057qib7 444 5 disease disease NN cord-005453-4057qib7 444 6 state state NN cord-005453-4057qib7 444 7 have have VBP cord-005453-4057qib7 444 8 a a DT cord-005453-4057qib7 444 9 more more RBR cord-005453-4057qib7 444 10 powerfull powerfull JJ cord-005453-4057qib7 444 11 effect effect NN cord-005453-4057qib7 444 12 on on IN cord-005453-4057qib7 444 13 survival survival NN cord-005453-4057qib7 444 14 in in IN cord-005453-4057qib7 444 15 the the DT cord-005453-4057qib7 444 16 Haplo Haplo NNP cord-005453-4057qib7 444 17 - - HYPH cord-005453-4057qib7 444 18 HSCT HSCT NNP cord-005453-4057qib7 444 19 setting setting NN cord-005453-4057qib7 444 20 ( ( -LRB- cord-005453-4057qib7 444 21 for for IN cord-005453-4057qib7 444 22 AML AML NNP cord-005453-4057qib7 444 23 CR1 CR1 NNP cord-005453-4057qib7 444 24 77 77 CD cord-005453-4057qib7 444 25 % % NN cord-005453-4057qib7 444 26 versus versus IN cord-005453-4057qib7 444 27 non non FW cord-005453-4057qib7 444 28 CR1 CR1 NNP cord-005453-4057qib7 444 29 33 33 CD cord-005453-4057qib7 444 30 % % NN cord-005453-4057qib7 444 31 and and CC cord-005453-4057qib7 444 32 for for IN cord-005453-4057qib7 444 33 ALL all DT cord-005453-4057qib7 444 34 CR1 CR1 NNP cord-005453-4057qib7 444 35 100 100 CD cord-005453-4057qib7 444 36 % % NN cord-005453-4057qib7 444 37 versus versus IN cord-005453-4057qib7 444 38 non non FW cord-005453-4057qib7 444 39 CR1 CR1 NNP cord-005453-4057qib7 444 40 0 0 CD cord-005453-4057qib7 444 41 % % NN cord-005453-4057qib7 444 42 ) ) -RRB- cord-005453-4057qib7 444 43 . . . cord-005453-4057qib7 445 1 Viral viral JJ cord-005453-4057qib7 445 2 reactivations reactivation NNS cord-005453-4057qib7 445 3 were be VBD cord-005453-4057qib7 445 4 significant significant JJ cord-005453-4057qib7 445 5 concern concern NN cord-005453-4057qib7 445 6 in in IN cord-005453-4057qib7 445 7 both both DT cord-005453-4057qib7 445 8 groups group NNS cord-005453-4057qib7 445 9 . . . cord-005453-4057qib7 446 1 Conclusions conclusion NNS cord-005453-4057qib7 446 2 : : : cord-005453-4057qib7 447 1 Our -PRON- PRP$ cord-005453-4057qib7 447 2 retrospective retrospective JJ cord-005453-4057qib7 447 3 analysis analysis NN cord-005453-4057qib7 447 4 suggests suggest VBZ cord-005453-4057qib7 447 5 largerly largerly RB cord-005453-4057qib7 447 6 similar similar JJ cord-005453-4057qib7 447 7 OS OS NNP cord-005453-4057qib7 447 8 and and CC cord-005453-4057qib7 447 9 DFS DFS NNP cord-005453-4057qib7 447 10 with with IN cord-005453-4057qib7 447 11 Haplo Haplo NNP cord-005453-4057qib7 447 12 versus versus IN cord-005453-4057qib7 447 13 unrelated unrelated JJ cord-005453-4057qib7 447 14 transplants transplant NNS cord-005453-4057qib7 447 15 with with IN cord-005453-4057qib7 447 16 PGCY PGCY NNP cord-005453-4057qib7 447 17 for for IN cord-005453-4057qib7 447 18 acute acute JJ cord-005453-4057qib7 447 19 leukemia leukemia NN cord-005453-4057qib7 447 20 . . . cord-005453-4057qib7 448 1 Our -PRON- PRP$ cord-005453-4057qib7 448 2 data datum NNS cord-005453-4057qib7 448 3 indicate indicate VBP cord-005453-4057qib7 448 4 that that IN cord-005453-4057qib7 448 5 Haplo Haplo NNP cord-005453-4057qib7 448 6 - - HYPH cord-005453-4057qib7 448 7 HSCT HSCT NNP cord-005453-4057qib7 448 8 results result NNS cord-005453-4057qib7 448 9 in in IN cord-005453-4057qib7 448 10 a a DT cord-005453-4057qib7 448 11 lower low JJR cord-005453-4057qib7 448 12 incidence incidence NN cord-005453-4057qib7 448 13 relapse relapse NN cord-005453-4057qib7 448 14 and and CC cord-005453-4057qib7 448 15 of of IN cord-005453-4057qib7 448 16 chronic chronic JJ cord-005453-4057qib7 448 17 GVHD GVHD NNP cord-005453-4057qib7 448 18 and and CC cord-005453-4057qib7 448 19 higher high JJR cord-005453-4057qib7 448 20 GRFS grfs NN cord-005453-4057qib7 448 21 compared compare VBN cord-005453-4057qib7 448 22 with with IN cord-005453-4057qib7 448 23 unrelated unrelated JJ cord-005453-4057qib7 448 24 HSCT HSCT NNP cord-005453-4057qib7 448 25 . . . cord-005453-4057qib7 449 1 In in IN cord-005453-4057qib7 449 2 addtion addtion NN cord-005453-4057qib7 449 3 , , , cord-005453-4057qib7 449 4 the the DT cord-005453-4057qib7 449 5 pretransplant pretransplant JJ cord-005453-4057qib7 449 6 disease disease NN cord-005453-4057qib7 449 7 state state NN cord-005453-4057qib7 449 8 have have VBP cord-005453-4057qib7 449 9 the the DT cord-005453-4057qib7 449 10 important important JJ cord-005453-4057qib7 449 11 effect effect NN cord-005453-4057qib7 449 12 on on IN cord-005453-4057qib7 449 13 the the DT cord-005453-4057qib7 449 14 outcomes outcome NNS cord-005453-4057qib7 449 15 in in IN cord-005453-4057qib7 449 16 both both DT cord-005453-4057qib7 449 17 groups group NNS cord-005453-4057qib7 449 18 . . . cord-005453-4057qib7 450 1 Allo Allo NNP cord-005453-4057qib7 450 2 - - HYPH cord-005453-4057qib7 450 3 PBSC PBSC NNP cord-005453-4057qib7 450 4 with with IN cord-005453-4057qib7 450 5 ATG ATG NNP cord-005453-4057qib7 450 6 can can MD cord-005453-4057qib7 450 7 be be VB cord-005453-4057qib7 450 8 used use VBN cord-005453-4057qib7 450 9 safely safely RB cord-005453-4057qib7 450 10 and and CC cord-005453-4057qib7 450 11 effective effective JJ cord-005453-4057qib7 450 12 as as IN cord-005453-4057qib7 450 13 graft graft NN cord-005453-4057qib7 450 14 source source NN cord-005453-4057qib7 450 15 in in IN cord-005453-4057qib7 450 16 Haplo Haplo NNP cord-005453-4057qib7 450 17 - - HYPH cord-005453-4057qib7 450 18 HSCT HSCT NNP cord-005453-4057qib7 450 19 with with IN cord-005453-4057qib7 450 20 acceptable acceptable JJ cord-005453-4057qib7 450 21 post post JJ cord-005453-4057qib7 450 22 - - JJ cord-005453-4057qib7 450 23 transplant transplant JJ cord-005453-4057qib7 450 24 outcomes outcome NNS cord-005453-4057qib7 450 25 and and CC cord-005453-4057qib7 450 26 replaced replace VBN cord-005453-4057qib7 450 27 BM BM NNP cord-005453-4057qib7 450 28 in in IN cord-005453-4057qib7 450 29 this this DT cord-005453-4057qib7 450 30 settings setting NNS cord-005453-4057qib7 450 31 . . . cord-005453-4057qib7 451 1 More More JJR cord-005453-4057qib7 451 2 statistical statistical JJ cord-005453-4057qib7 451 3 data datum NNS cord-005453-4057qib7 451 4 for for IN cord-005453-4057qib7 451 5 transplant transplant NN cord-005453-4057qib7 451 6 related relate VBN cord-005453-4057qib7 451 7 characteristics characteristic NNS cord-005453-4057qib7 451 8 will will MD cord-005453-4057qib7 451 9 be be VB cord-005453-4057qib7 451 10 provided provide VBN cord-005453-4057qib7 451 11 at at IN cord-005453-4057qib7 451 12 the the DT cord-005453-4057qib7 451 13 presentation presentation NN cord-005453-4057qib7 451 14 . . . cord-005453-4057qib7 452 1 We -PRON- PRP cord-005453-4057qib7 452 2 emphasize emphasize VBP cord-005453-4057qib7 452 3 that that IN cord-005453-4057qib7 452 4 use use VBP cord-005453-4057qib7 452 5 the the DT cord-005453-4057qib7 452 6 same same JJ cord-005453-4057qib7 452 7 PGCY pgcy JJ cord-005453-4057qib7 452 8 GVHD GVHD NNP cord-005453-4057qib7 452 9 prophylaxis prophylaxis NN cord-005453-4057qib7 452 10 for for IN cord-005453-4057qib7 452 11 all all DT cord-005453-4057qib7 452 12 types type NNS cord-005453-4057qib7 452 13 of of IN cord-005453-4057qib7 452 14 allogeneic allogeneic NN cord-005453-4057qib7 452 15 transplant transplant NN cord-005453-4057qib7 452 16 . . . cord-005453-4057qib7 453 1 Based base VBN cord-005453-4057qib7 453 2 on on IN cord-005453-4057qib7 453 3 our -PRON- PRP$ cord-005453-4057qib7 453 4 results result NNS cord-005453-4057qib7 453 5 , , , cord-005453-4057qib7 453 6 we -PRON- PRP cord-005453-4057qib7 453 7 recommend recommend VBP cord-005453-4057qib7 453 8 Haplo Haplo NNP cord-005453-4057qib7 453 9 - - HYPH cord-005453-4057qib7 453 10 HSCT HSCT NNP cord-005453-4057qib7 453 11 with with IN cord-005453-4057qib7 453 12 PGCY PGCY NNP cord-005453-4057qib7 453 13 against against IN cord-005453-4057qib7 453 14 unrelated unrelated JJ cord-005453-4057qib7 453 15 transplant transplant NN cord-005453-4057qib7 453 16 for for IN cord-005453-4057qib7 453 17 patients patient NNS cord-005453-4057qib7 453 18 with with IN cord-005453-4057qib7 453 19 acute acute JJ cord-005453-4057qib7 453 20 leukemia leukemia NN cord-005453-4057qib7 453 21 . . . cord-005453-4057qib7 454 1 Disclosure disclosure NN cord-005453-4057qib7 454 2 : : : cord-005453-4057qib7 454 3 Disclosure disclosure NN cord-005453-4057qib7 454 4 of of IN cord-005453-4057qib7 454 5 conflict conflict NN cord-005453-4057qib7 454 6 of of IN cord-005453-4057qib7 454 7 interest interest NN cord-005453-4057qib7 454 8 : : : cord-005453-4057qib7 454 9 None none NN cord-005453-4057qib7 454 10 . . . cord-005453-4057qib7 455 1 Excellent excellent JJ cord-005453-4057qib7 455 2 efficacy efficacy NN cord-005453-4057qib7 455 3 and and CC cord-005453-4057qib7 455 4 tolerability tolerability NN cord-005453-4057qib7 455 5 of of IN cord-005453-4057qib7 455 6 inotuzumab inotuzumab NNS cord-005453-4057qib7 455 7 ozogamicin ozogamicin NNS cord-005453-4057qib7 455 8 in in IN cord-005453-4057qib7 455 9 B b NN cord-005453-4057qib7 455 10 - - HYPH cord-005453-4057qib7 455 11 cell cell NN cord-005453-4057qib7 455 12 all all DT cord-005453-4057qib7 455 13 relapsed relapse VBD cord-005453-4057qib7 455 14 after after IN cord-005453-4057qib7 455 15 allo allo NN cord-005453-4057qib7 455 16 - - HYPH cord-005453-4057qib7 455 17 HSCT HSCT NNP cord-005453-4057qib7 455 18 Background background NN cord-005453-4057qib7 455 19 : : : cord-005453-4057qib7 456 1 Donor donor NN cord-005453-4057qib7 456 2 lymphocyte lymphocyte NN cord-005453-4057qib7 456 3 infusion infusion NN cord-005453-4057qib7 456 4 ( ( -LRB- cord-005453-4057qib7 456 5 DLI DLI NNP cord-005453-4057qib7 456 6 ) ) -RRB- cord-005453-4057qib7 456 7 could could MD cord-005453-4057qib7 456 8 be be VB cord-005453-4057qib7 456 9 used use VBN cord-005453-4057qib7 456 10 prophylactically prophylactically RB cord-005453-4057qib7 456 11 to to TO cord-005453-4057qib7 456 12 reduce reduce VB cord-005453-4057qib7 456 13 relapse relapse NN cord-005453-4057qib7 456 14 after after IN cord-005453-4057qib7 456 15 allogeneic allogeneic JJ cord-005453-4057qib7 456 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 456 17 stem stem NN cord-005453-4057qib7 456 18 cell cell NN cord-005453-4057qib7 456 19 transplantation transplantation NN cord-005453-4057qib7 456 20 for for IN cord-005453-4057qib7 456 21 very very RB cord-005453-4057qib7 456 22 high high JJ cord-005453-4057qib7 456 23 - - HYPH cord-005453-4057qib7 456 24 risk risk NN cord-005453-4057qib7 456 25 leukemia leukemia NN cord-005453-4057qib7 456 26 / / SYM cord-005453-4057qib7 456 27 lymphoma lymphoma NN cord-005453-4057qib7 456 28 without without IN cord-005453-4057qib7 456 29 effective effective JJ cord-005453-4057qib7 456 30 targeted target VBN cord-005453-4057qib7 456 31 therapy therapy NN cord-005453-4057qib7 456 32 . . . cord-005453-4057qib7 457 1 To to TO cord-005453-4057qib7 457 2 compare compare VB cord-005453-4057qib7 457 3 the the DT cord-005453-4057qib7 457 4 safety safety NN cord-005453-4057qib7 457 5 and and CC cord-005453-4057qib7 457 6 efficacy efficacy NN cord-005453-4057qib7 457 7 of of IN cord-005453-4057qib7 457 8 prophylactic prophylactic JJ cord-005453-4057qib7 457 9 DLI DLI NNP cord-005453-4057qib7 457 10 for for IN cord-005453-4057qib7 457 11 prevention prevention NN cord-005453-4057qib7 457 12 of of IN cord-005453-4057qib7 457 13 relapse relapse NN cord-005453-4057qib7 457 14 after after IN cord-005453-4057qib7 457 15 allogeneic allogeneic IN cord-005453-4057qib7 457 16 peripheral peripheral JJ cord-005453-4057qib7 457 17 blood blood NN cord-005453-4057qib7 457 18 stem stem NN cord-005453-4057qib7 457 19 cell cell NN cord-005453-4057qib7 457 20 transplantation transplantation NN cord-005453-4057qib7 457 21 from from IN cord-005453-4057qib7 457 22 haploidentical haploidentical JJ cord-005453-4057qib7 457 23 donors donor NNS cord-005453-4057qib7 457 24 ( ( -LRB- cord-005453-4057qib7 457 25 HID HID NNP cord-005453-4057qib7 457 26 - - HYPH cord-005453-4057qib7 457 27 SCT SCT NNP cord-005453-4057qib7 457 28 ) ) -RRB- cord-005453-4057qib7 457 29 and and CC cord-005453-4057qib7 457 30 matched match VBN cord-005453-4057qib7 457 31 - - HYPH cord-005453-4057qib7 457 32 sibling sibling NN cord-005453-4057qib7 457 33 donors donor NNS cord-005453-4057qib7 457 34 ( ( -LRB- cord-005453-4057qib7 457 35 MSD MSD NNP cord-005453-4057qib7 457 36 - - HYPH cord-005453-4057qib7 457 37 SCT SCT NNP cord-005453-4057qib7 457 38 ) ) -RRB- cord-005453-4057qib7 457 39 in in IN cord-005453-4057qib7 457 40 patients patient NNS cord-005453-4057qib7 457 41 with with IN cord-005453-4057qib7 457 42 very very RB cord-005453-4057qib7 457 43 high high JJ cord-005453-4057qib7 457 44 - - HYPH cord-005453-4057qib7 457 45 risk risk NN cord-005453-4057qib7 457 46 acute acute JJ cord-005453-4057qib7 457 47 myeloid myeloid NN cord-005453-4057qib7 457 48 leukemia leukemia NN cord-005453-4057qib7 457 49 ( ( -LRB- cord-005453-4057qib7 457 50 AML AML NNP cord-005453-4057qib7 457 51 ) ) -RRB- cord-005453-4057qib7 457 52 , , , cord-005453-4057qib7 457 53 we -PRON- PRP cord-005453-4057qib7 457 54 performed perform VBD cord-005453-4057qib7 457 55 a a DT cord-005453-4057qib7 457 56 retrospective retrospective JJ cord-005453-4057qib7 457 57 , , , cord-005453-4057qib7 457 58 observational observational JJ cord-005453-4057qib7 457 59 cohort cohort NN cord-005453-4057qib7 457 60 study study NN cord-005453-4057qib7 457 61 enrolled enrol VBD cord-005453-4057qib7 457 62 in in IN cord-005453-4057qib7 457 63 21 21 CD cord-005453-4057qib7 457 64 HID HID NNP cord-005453-4057qib7 457 65 - - HYPH cord-005453-4057qib7 457 66 SCT SCT NNP cord-005453-4057qib7 457 67 and and CC cord-005453-4057qib7 457 68 13 13 CD cord-005453-4057qib7 457 69 MSD MSD NNP cord-005453-4057qib7 457 70 - - HYPH cord-005453-4057qib7 457 71 SCT SCT NNP cord-005453-4057qib7 457 72 recipients recipient NNS cord-005453-4057qib7 457 73 . . . cord-005453-4057qib7 458 1 Methods method NNS cord-005453-4057qib7 458 2 : : : cord-005453-4057qib7 458 3 The the DT cord-005453-4057qib7 458 4 very very RB cord-005453-4057qib7 458 5 high high JJ cord-005453-4057qib7 458 6 - - HYPH cord-005453-4057qib7 458 7 risk risk NN cord-005453-4057qib7 458 8 features feature NNS cord-005453-4057qib7 458 9 were be VBD cord-005453-4057qib7 458 10 defined define VBN cord-005453-4057qib7 458 11 as as IN cord-005453-4057qib7 458 12 : : : cord-005453-4057qib7 458 13 ( ( -LRB- cord-005453-4057qib7 458 14 i i NN cord-005453-4057qib7 458 15 ) ) -RRB- cord-005453-4057qib7 458 16 in in IN cord-005453-4057qib7 458 17 the the DT cord-005453-4057qib7 458 18 non non JJ cord-005453-4057qib7 458 19 - - JJ cord-005453-4057qib7 458 20 remission remission JJ cord-005453-4057qib7 458 21 ( ( -LRB- cord-005453-4057qib7 458 22 NR NR NNP cord-005453-4057qib7 458 23 ) ) -RRB- cord-005453-4057qib7 458 24 state state NN cord-005453-4057qib7 458 25 prior prior RB cord-005453-4057qib7 458 26 to to IN cord-005453-4057qib7 458 27 transplantation transplantation NN cord-005453-4057qib7 458 28 , , , cord-005453-4057qib7 458 29 including include VBG cord-005453-4057qib7 458 30 primary primary JJ cord-005453-4057qib7 458 31 induction induction NN cord-005453-4057qib7 458 32 failure failure NN cord-005453-4057qib7 458 33 , , , cord-005453-4057qib7 458 34 relapse relapse NN cord-005453-4057qib7 458 35 untreated untreated JJ cord-005453-4057qib7 458 36 or or CC cord-005453-4057qib7 458 37 refractory refractory JJ cord-005453-4057qib7 458 38 to to IN cord-005453-4057qib7 458 39 reinduction reinduction NN cord-005453-4057qib7 458 40 chemotherapy chemotherapy NN cord-005453-4057qib7 458 41 , , , cord-005453-4057qib7 458 42 or or CC cord-005453-4057qib7 458 43 untreated untreated JJ cord-005453-4057qib7 458 44 AML AML NNP cord-005453-4057qib7 458 45 evolution evolution NN cord-005453-4057qib7 458 46 from from IN cord-005453-4057qib7 458 47 MDS MDS NNP cord-005453-4057qib7 458 48 ; ; : cord-005453-4057qib7 458 49 ( ( -LRB- cord-005453-4057qib7 458 50 ii ii NN cord-005453-4057qib7 458 51 ) ) -RRB- cord-005453-4057qib7 458 52 achieving achieve VBG cord-005453-4057qib7 458 53 complete complete JJ cord-005453-4057qib7 458 54 remission remission NN cord-005453-4057qib7 458 55 1 1 CD cord-005453-4057qib7 458 56 with with IN cord-005453-4057qib7 458 57 ≥3 ≥3 NNP cord-005453-4057qib7 458 58 cycles cycle NNS cord-005453-4057qib7 458 59 of of IN cord-005453-4057qib7 458 60 induction induction NN cord-005453-4057qib7 458 61 of of IN cord-005453-4057qib7 458 62 chemotherapy chemotherapy NN cord-005453-4057qib7 458 63 ; ; : cord-005453-4057qib7 458 64 ( ( -LRB- cord-005453-4057qib7 458 65 iii iii NN cord-005453-4057qib7 458 66 ) ) -RRB- cord-005453-4057qib7 458 67 carrying carry VBG cord-005453-4057qib7 458 68 TP53 TP53 NNP cord-005453-4057qib7 458 69 , , , cord-005453-4057qib7 458 70 DNMT3a dnmt3a UH cord-005453-4057qib7 458 71 , , , cord-005453-4057qib7 458 72 TET2 TET2 NNP cord-005453-4057qib7 458 73 or or CC cord-005453-4057qib7 458 74 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 458 75 gene gene NN cord-005453-4057qib7 458 76 mutation mutation NN cord-005453-4057qib7 458 77 . . . cord-005453-4057qib7 459 1 The the DT cord-005453-4057qib7 459 2 scheduled schedule VBN cord-005453-4057qib7 459 3 time time NN cord-005453-4057qib7 459 4 of of IN cord-005453-4057qib7 459 5 the the DT cord-005453-4057qib7 459 6 prophylactic prophylactic JJ cord-005453-4057qib7 459 7 DLI DLI NNP cord-005453-4057qib7 459 8 was be VBD cord-005453-4057qib7 459 9 +30 +30 CD cord-005453-4057qib7 459 10 - - SYM cord-005453-4057qib7 459 11 60 60 CD cord-005453-4057qib7 459 12 days day NNS cord-005453-4057qib7 459 13 after after IN cord-005453-4057qib7 459 14 transplantation transplantation NN cord-005453-4057qib7 459 15 for for IN cord-005453-4057qib7 459 16 MSD MSD NNP cord-005453-4057qib7 459 17 - - HYPH cord-005453-4057qib7 459 18 SCT SCT NNP cord-005453-4057qib7 459 19 recipients recipient NNS cord-005453-4057qib7 459 20 and and CC cord-005453-4057qib7 459 21 +60 +60 CD cord-005453-4057qib7 459 22 - - SYM cord-005453-4057qib7 459 23 90 90 CD cord-005453-4057qib7 459 24 days day NNS cord-005453-4057qib7 459 25 for for IN cord-005453-4057qib7 459 26 HID HID NNP cord-005453-4057qib7 459 27 - - HYPH cord-005453-4057qib7 459 28 SCT SCT NNP cord-005453-4057qib7 459 29 recipients recipient NNS cord-005453-4057qib7 459 30 . . . cord-005453-4057qib7 460 1 The the DT cord-005453-4057qib7 460 2 G g NN cord-005453-4057qib7 460 3 - - HYPH cord-005453-4057qib7 460 4 CSFmobilized csfmobilize VBN cord-005453-4057qib7 460 5 peripheral peripheral JJ cord-005453-4057qib7 460 6 blood blood NN cord-005453-4057qib7 460 7 stem stem NN cord-005453-4057qib7 460 8 cells cell NNS cord-005453-4057qib7 460 9 were be VBD cord-005453-4057qib7 460 10 infused infuse VBN cord-005453-4057qib7 460 11 to to IN cord-005453-4057qib7 460 12 the the DT cord-005453-4057qib7 460 13 recipient recipient NN cord-005453-4057qib7 460 14 at at IN cord-005453-4057qib7 460 15 a a DT cord-005453-4057qib7 460 16 dose dose NN cord-005453-4057qib7 460 17 of of IN cord-005453-4057qib7 460 18 2×10 2×10 CD cord-005453-4057qib7 460 19 7 7 CD cord-005453-4057qib7 460 20 CD3 CD3 NNS cord-005453-4057qib7 460 21 + + CC cord-005453-4057qib7 460 22 cells cell NNS cord-005453-4057qib7 460 23 / / SYM cord-005453-4057qib7 460 24 kg kg NNS cord-005453-4057qib7 460 25 . . . cord-005453-4057qib7 461 1 CsA CsA NNP cord-005453-4057qib7 461 2 was be VBD cord-005453-4057qib7 461 3 given give VBN cord-005453-4057qib7 461 4 at at IN cord-005453-4057qib7 461 5 2 2 CD cord-005453-4057qib7 461 6 mg mg NNP cord-005453-4057qib7 461 7 / / SYM cord-005453-4057qib7 461 8 kg kg NNP cord-005453-4057qib7 461 9 b.i.d b.i.d NNP cord-005453-4057qib7 461 10 from from IN cord-005453-4057qib7 461 11 day day NN cord-005453-4057qib7 461 12 -3 -3 NNP cord-005453-4057qib7 461 13 to to IN cord-005453-4057qib7 461 14 day day NN cord-005453-4057qib7 461 15 +90 +90 CD cord-005453-4057qib7 461 16 ( ( -LRB- cord-005453-4057qib7 461 17 HID HID NNP cord-005453-4057qib7 461 18 - - HYPH cord-005453-4057qib7 461 19 SCT SCT NNP cord-005453-4057qib7 461 20 ) ) -RRB- cord-005453-4057qib7 461 21 or or CC cord-005453-4057qib7 461 22 to to IN cord-005453-4057qib7 461 23 day day NN cord-005453-4057qib7 461 24 +60 +60 CD cord-005453-4057qib7 461 25 ( ( -LRB- cord-005453-4057qib7 461 26 MSD MSD NNP cord-005453-4057qib7 461 27 - - HYPH cord-005453-4057qib7 461 28 SCT SCT NNP cord-005453-4057qib7 461 29 ) ) -RRB- cord-005453-4057qib7 461 30 , , , cord-005453-4057qib7 461 31 and and CC cord-005453-4057qib7 461 32 then then RB cord-005453-4057qib7 461 33 tapered taper VBD cord-005453-4057qib7 461 34 at at IN cord-005453-4057qib7 461 35 33 33 CD cord-005453-4057qib7 461 36 % % NN cord-005453-4057qib7 461 37 per per IN cord-005453-4057qib7 461 38 month month NN cord-005453-4057qib7 461 39 to to TO cord-005453-4057qib7 461 40 be be VB cord-005453-4057qib7 461 41 discontinued discontinue VBN cord-005453-4057qib7 461 42 on on IN cord-005453-4057qib7 461 43 day day NN cord-005453-4057qib7 461 44 +150 +150 NNP cord-005453-4057qib7 461 45 - - HYPH cord-005453-4057qib7 461 46 180 180 CD cord-005453-4057qib7 461 47 ( ( -LRB- cord-005453-4057qib7 461 48 HID HID NNP cord-005453-4057qib7 461 49 - - HYPH cord-005453-4057qib7 461 50 SCT SCT NNP cord-005453-4057qib7 461 51 ) ) -RRB- cord-005453-4057qib7 461 52 or or CC cord-005453-4057qib7 461 53 on on IN cord-005453-4057qib7 461 54 day day NN cord-005453-4057qib7 461 55 +120 +120 NNP cord-005453-4057qib7 461 56 - - HYPH cord-005453-4057qib7 461 57 150 150 CD cord-005453-4057qib7 461 58 ( ( -LRB- cord-005453-4057qib7 461 59 MSD MSD NNP cord-005453-4057qib7 461 60 - - HYPH cord-005453-4057qib7 461 61 SCT SCT NNP cord-005453-4057qib7 461 62 ) ) -RRB- cord-005453-4057qib7 461 63 unless unless IN cord-005453-4057qib7 461 64 graft graft NN cord-005453-4057qib7 461 65 - - HYPH cord-005453-4057qib7 461 66 versus versus IN cord-005453-4057qib7 461 67 - - HYPH cord-005453-4057qib7 461 68 host host NN cord-005453-4057qib7 461 69 disease disease NN cord-005453-4057qib7 461 70 ( ( -LRB- cord-005453-4057qib7 461 71 GVHD GVHD NNP cord-005453-4057qib7 461 72 ) ) -RRB- cord-005453-4057qib7 461 73 developed develop VBD cord-005453-4057qib7 461 74 . . . cord-005453-4057qib7 462 1 If if IN cord-005453-4057qib7 462 2 the the DT cord-005453-4057qib7 462 3 patients patient NNS cord-005453-4057qib7 462 4 received receive VBD cord-005453-4057qib7 462 5 DLI DLI NNP cord-005453-4057qib7 462 6 before before IN cord-005453-4057qib7 462 7 day day NN cord-005453-4057qib7 462 8 +90 +90 NFP cord-005453-4057qib7 462 9 ( ( -LRB- cord-005453-4057qib7 462 10 HID HID NNP cord-005453-4057qib7 462 11 - - HYPH cord-005453-4057qib7 462 12 SCT SCT NNP cord-005453-4057qib7 462 13 ) ) -RRB- cord-005453-4057qib7 462 14 or or CC cord-005453-4057qib7 462 15 day day NN cord-005453-4057qib7 462 16 +60 +60 NNP cord-005453-4057qib7 462 17 ( ( -LRB- cord-005453-4057qib7 462 18 MSD MSD NNP cord-005453-4057qib7 462 19 - - HYPH cord-005453-4057qib7 462 20 SCT SCT NNP cord-005453-4057qib7 462 21 ) ) -RRB- cord-005453-4057qib7 462 22 , , , cord-005453-4057qib7 462 23 CsA CsA NNP cord-005453-4057qib7 462 24 was be VBD cord-005453-4057qib7 462 25 given give VBN cord-005453-4057qib7 462 26 8 8 CD cord-005453-4057qib7 462 27 weeks week NNS cord-005453-4057qib7 462 28 after after IN cord-005453-4057qib7 462 29 DLI DLI NNP cord-005453-4057qib7 462 30 in in IN cord-005453-4057qib7 462 31 HID HID NNP cord-005453-4057qib7 462 32 group group NN cord-005453-4057qib7 462 33 and and CC cord-005453-4057qib7 462 34 4 4 CD cord-005453-4057qib7 462 35 weeks week NNS cord-005453-4057qib7 462 36 in in IN cord-005453-4057qib7 462 37 MSD MSD NNP cord-005453-4057qib7 462 38 group group NN cord-005453-4057qib7 462 39 at at IN cord-005453-4057qib7 462 40 a a DT cord-005453-4057qib7 462 41 though though JJ cord-005453-4057qib7 462 42 concentration concentration NN cord-005453-4057qib7 462 43 of of IN cord-005453-4057qib7 462 44 150 150 CD cord-005453-4057qib7 462 45 - - SYM cord-005453-4057qib7 462 46 250 250 CD cord-005453-4057qib7 462 47 ng ng NN cord-005453-4057qib7 462 48 / / SYM cord-005453-4057qib7 462 49 ml ml NN cord-005453-4057qib7 462 50 for for IN cord-005453-4057qib7 462 51 DLIassociated dliassociated JJ cord-005453-4057qib7 462 52 GVHD GVHD NNP cord-005453-4057qib7 462 53 prophylaxis prophylaxis NN cord-005453-4057qib7 462 54 , , , cord-005453-4057qib7 462 55 and and CC cord-005453-4057qib7 462 56 then then RB cord-005453-4057qib7 462 57 tapered taper VBD cord-005453-4057qib7 462 58 and and CC cord-005453-4057qib7 462 59 discontinued discontinue VBD cord-005453-4057qib7 462 60 within within IN cord-005453-4057qib7 462 61 2 2 CD cord-005453-4057qib7 462 62 weeks week NNS cord-005453-4057qib7 462 63 unless unless IN cord-005453-4057qib7 462 64 GVHD GVHD NNP cord-005453-4057qib7 462 65 developed develop VBD cord-005453-4057qib7 462 66 . . . cord-005453-4057qib7 463 1 If if IN cord-005453-4057qib7 463 2 GVHD GVHD NNP cord-005453-4057qib7 463 3 occurred occur VBD cord-005453-4057qib7 463 4 before before IN cord-005453-4057qib7 463 5 the the DT cord-005453-4057qib7 463 6 scheduled schedule VBN cord-005453-4057qib7 463 7 time time NN cord-005453-4057qib7 463 8 of of IN cord-005453-4057qib7 463 9 prophylactic prophylactic JJ cord-005453-4057qib7 463 10 DLI DLI NNP cord-005453-4057qib7 463 11 , , , cord-005453-4057qib7 463 12 it -PRON- PRP cord-005453-4057qib7 463 13 would would MD cord-005453-4057qib7 463 14 be be VB cord-005453-4057qib7 463 15 delayed delay VBN cord-005453-4057qib7 463 16 for for IN cord-005453-4057qib7 463 17 8 8 CD cord-005453-4057qib7 463 18 weeks week NNS cord-005453-4057qib7 463 19 when when WRB cord-005453-4057qib7 463 20 GVHD GVHD NNP cord-005453-4057qib7 463 21 was be VBD cord-005453-4057qib7 463 22 well well RB cord-005453-4057qib7 463 23 controlled control VBN cord-005453-4057qib7 463 24 . . . cord-005453-4057qib7 464 1 Results result NNS cord-005453-4057qib7 464 2 : : : cord-005453-4057qib7 465 1 Prophylactic prophylactic JJ cord-005453-4057qib7 465 2 DLI DLI NNP cord-005453-4057qib7 465 3 was be VBD cord-005453-4057qib7 465 4 administered administer VBN cord-005453-4057qib7 465 5 at at IN cord-005453-4057qib7 465 6 a a DT cord-005453-4057qib7 465 7 median median NN cord-005453-4057qib7 465 8 of of IN cord-005453-4057qib7 465 9 71 71 CD cord-005453-4057qib7 465 10 ( ( -LRB- cord-005453-4057qib7 465 11 34 34 CD cord-005453-4057qib7 465 12 - - SYM cord-005453-4057qib7 465 13 240 240 CD cord-005453-4057qib7 465 14 ) ) -RRB- cord-005453-4057qib7 465 15 days day NNS cord-005453-4057qib7 465 16 for for IN cord-005453-4057qib7 465 17 HID HID NNP cord-005453-4057qib7 465 18 - - HYPH cord-005453-4057qib7 465 19 SCT SCT NNP cord-005453-4057qib7 465 20 recipients recipient NNS cord-005453-4057qib7 465 21 and and CC cord-005453-4057qib7 465 22 53 53 CD cord-005453-4057qib7 465 23 ( ( -LRB- cord-005453-4057qib7 465 24 35 35 CD cord-005453-4057qib7 465 25 - - SYM cord-005453-4057qib7 465 26 97 97 CD cord-005453-4057qib7 465 27 ) ) -RRB- cord-005453-4057qib7 465 28 days day NNS cord-005453-4057qib7 465 29 for for IN cord-005453-4057qib7 465 30 MSD MSD NNP cord-005453-4057qib7 465 31 - - HYPH cord-005453-4057qib7 465 32 SCT SCT NNP cord-005453-4057qib7 465 33 recipients recipient NNS cord-005453-4057qib7 465 34 ( ( -LRB- cord-005453-4057qib7 465 35 p=0.008 p=0.008 NNP cord-005453-4057qib7 465 36 ) ) -RRB- cord-005453-4057qib7 465 37 , , , cord-005453-4057qib7 465 38 and and CC cord-005453-4057qib7 465 39 both both DT cord-005453-4057qib7 465 40 groups group NNS cord-005453-4057qib7 465 41 displayed display VBD cord-005453-4057qib7 465 42 similar similar JJ cord-005453-4057qib7 465 43 baseline baseline JJ cord-005453-4057qib7 465 44 characteristics characteristic NNS cord-005453-4057qib7 465 45 except except IN cord-005453-4057qib7 465 46 for for IN cord-005453-4057qib7 465 47 donor donor NN cord-005453-4057qib7 465 48 's 's POS cord-005453-4057qib7 465 49 gender gender NN cord-005453-4057qib7 465 50 distribution distribution NN cord-005453-4057qib7 465 51 ( ( -LRB- cord-005453-4057qib7 465 52 Table table NN cord-005453-4057qib7 465 53 1 1 CD cord-005453-4057qib7 465 54 ) ) -RRB- cord-005453-4057qib7 465 55 . . . cord-005453-4057qib7 466 1 Grade grade NN cord-005453-4057qib7 466 2 2 2 CD cord-005453-4057qib7 466 3 - - SYM cord-005453-4057qib7 466 4 4 4 CD cord-005453-4057qib7 466 5 acute acute JJ cord-005453-4057qib7 466 6 graft graft NN cord-005453-4057qib7 466 7 - - HYPH cord-005453-4057qib7 466 8 versushost versushost NN cord-005453-4057qib7 466 9 disease disease NN cord-005453-4057qib7 466 10 ( ( -LRB- cord-005453-4057qib7 466 11 GVHD GVHD NNP cord-005453-4057qib7 466 12 ) ) -RRB- cord-005453-4057qib7 466 13 at at IN cord-005453-4057qib7 466 14 100-day 100-day CD cord-005453-4057qib7 466 15 post post NNP cord-005453-4057qib7 466 16 - - NNP cord-005453-4057qib7 466 17 DLI DLI NNP cord-005453-4057qib7 466 18 was be VBD cord-005453-4057qib7 466 19 higher high JJR cord-005453-4057qib7 466 20 in in IN cord-005453-4057qib7 466 21 HID HID NNP cord-005453-4057qib7 466 22 - - HYPH cord-005453-4057qib7 466 23 SCT SCT NNP cord-005453-4057qib7 466 24 group group NN cord-005453-4057qib7 466 25 than than IN cord-005453-4057qib7 466 26 that that DT cord-005453-4057qib7 466 27 in in IN cord-005453-4057qib7 466 28 MSD MSD NNP cord-005453-4057qib7 466 29 - - HYPH cord-005453-4057qib7 466 30 SCT SCT NNP cord-005453-4057qib7 466 31 group group NN cord-005453-4057qib7 466 32 ( ( -LRB- cord-005453-4057qib7 466 33 59.5 59.5 CD cord-005453-4057qib7 466 34 % % NN cord-005453-4057qib7 466 35 vs. vs. CC cord-005453-4057qib7 466 36 30.8 30.8 CD cord-005453-4057qib7 466 37 % % NN cord-005453-4057qib7 466 38 , , , cord-005453-4057qib7 466 39 p=0.05 p=0.05 NNP cord-005453-4057qib7 466 40 ) ) -RRB- cord-005453-4057qib7 466 41 . . . cord-005453-4057qib7 467 1 Grade grade NN cord-005453-4057qib7 467 2 3 3 CD cord-005453-4057qib7 467 3 - - SYM cord-005453-4057qib7 467 4 4 4 CD cord-005453-4057qib7 467 5 acute acute JJ cord-005453-4057qib7 467 6 GVHD GVHD NNP cord-005453-4057qib7 467 7 ( ( -LRB- cord-005453-4057qib7 467 8 17.5 17.5 CD cord-005453-4057qib7 467 9 % % NN cord-005453-4057qib7 467 10 vs. vs. CC cord-005453-4057qib7 467 11 7.7 7.7 CD cord-005453-4057qib7 467 12 % % NN cord-005453-4057qib7 467 13 ) ) -RRB- cord-005453-4057qib7 467 14 , , , cord-005453-4057qib7 467 15 1-year 1-year CD cord-005453-4057qib7 467 16 chronic chronic JJ cord-005453-4057qib7 467 17 GVHD GVHD NNP cord-005453-4057qib7 467 18 ( ( -LRB- cord-005453-4057qib7 467 19 36.6 36.6 CD cord-005453-4057qib7 467 20 % % NN cord-005453-4057qib7 467 21 vs. vs. NN cord-005453-4057qib7 467 22 33.2 33.2 CD cord-005453-4057qib7 467 23 % % NN cord-005453-4057qib7 467 24 ) ) -RRB- cord-005453-4057qib7 467 25 and and CC cord-005453-4057qib7 467 26 severe severe JJ cord-005453-4057qib7 467 27 chronic chronic JJ cord-005453-4057qib7 467 28 GVHD GVHD NNP cord-005453-4057qib7 467 29 ( ( -LRB- cord-005453-4057qib7 467 30 15.3 15.3 CD cord-005453-4057qib7 467 31 % % NN cord-005453-4057qib7 467 32 vs. vs. CC cord-005453-4057qib7 467 33 27.3 27.3 CD cord-005453-4057qib7 467 34 % % NN cord-005453-4057qib7 467 35 ) ) -RRB- cord-005453-4057qib7 467 36 were be VBD cord-005453-4057qib7 467 37 similar similar JJ cord-005453-4057qib7 467 38 between between IN cord-005453-4057qib7 467 39 two two CD cord-005453-4057qib7 467 40 groups group NNS cord-005453-4057qib7 467 41 ( ( -LRB- cord-005453-4057qib7 467 42 p>0.05 p>0.05 NNP cord-005453-4057qib7 467 43 ) ) -RRB- cord-005453-4057qib7 467 44 . . . cord-005453-4057qib7 468 1 One one CD cord-005453-4057qib7 468 2 - - HYPH cord-005453-4057qib7 468 3 year year NN cord-005453-4057qib7 468 4 non non JJ cord-005453-4057qib7 468 5 - - JJ cord-005453-4057qib7 468 6 relapse relapse JJ cord-005453-4057qib7 468 7 mortality mortality NN cord-005453-4057qib7 468 8 was be VBD cord-005453-4057qib7 468 9 higher high JJR cord-005453-4057qib7 468 10 in in IN cord-005453-4057qib7 468 11 HID HID NNP cord-005453-4057qib7 468 12 - - HYPH cord-005453-4057qib7 468 13 SCT SCT NNP cord-005453-4057qib7 468 14 group group NN cord-005453-4057qib7 468 15 than than IN cord-005453-4057qib7 468 16 that that DT cord-005453-4057qib7 468 17 in in IN cord-005453-4057qib7 468 18 MSD MSD NNP cord-005453-4057qib7 468 19 - - HYPH cord-005453-4057qib7 468 20 SCT SCT NNP cord-005453-4057qib7 468 21 group group NN cord-005453-4057qib7 468 22 with with IN cord-005453-4057qib7 468 23 marginal marginal JJ cord-005453-4057qib7 468 24 significance significance NN cord-005453-4057qib7 468 25 ( ( -LRB- cord-005453-4057qib7 468 26 27.9 27.9 CD cord-005453-4057qib7 468 27 % % NN cord-005453-4057qib7 468 28 vs. vs. IN cord-005453-4057qib7 468 29 0.0 0.0 CD cord-005453-4057qib7 468 30 % % NN cord-005453-4057qib7 468 31 , , , cord-005453-4057qib7 468 32 p=0.061 p=0.061 NNP cord-005453-4057qib7 468 33 ) ) -RRB- cord-005453-4057qib7 468 34 . . . cord-005453-4057qib7 469 1 One one CD cord-005453-4057qib7 469 2 - - HYPH cord-005453-4057qib7 469 3 year year NN cord-005453-4057qib7 469 4 relapse relapse NN cord-005453-4057qib7 469 5 rate rate NN cord-005453-4057qib7 469 6 was be VBD cord-005453-4057qib7 469 7 similar similar JJ cord-005453-4057qib7 469 8 between between IN cord-005453-4057qib7 469 9 HID HID NNP cord-005453-4057qib7 469 10 - - HYPH cord-005453-4057qib7 469 11 SCT SCT NNP cord-005453-4057qib7 469 12 group group NN cord-005453-4057qib7 469 13 and and CC cord-005453-4057qib7 469 14 MSD MSD NNP cord-005453-4057qib7 469 15 - - HYPH cord-005453-4057qib7 469 16 SCT SCT NNP cord-005453-4057qib7 469 17 group group NN cord-005453-4057qib7 469 18 ( ( -LRB- cord-005453-4057qib7 469 19 21.6 21.6 CD cord-005453-4057qib7 469 20 % % NN cord-005453-4057qib7 469 21 vs. vs. CC cord-005453-4057qib7 469 22 36.5 36.5 CD cord-005453-4057qib7 469 23 % % NN cord-005453-4057qib7 469 24 , , , cord-005453-4057qib7 469 25 p>0.05 p>0.05 NNP cord-005453-4057qib7 469 26 ) ) -RRB- cord-005453-4057qib7 469 27 . . . cord-005453-4057qib7 470 1 Estimated estimate VBN cord-005453-4057qib7 470 2 1-year 1-year CD cord-005453-4057qib7 470 3 overall overall JJ cord-005453-4057qib7 470 4 survival survival NN cord-005453-4057qib7 470 5 ( ( -LRB- cord-005453-4057qib7 470 6 OS OS NNP cord-005453-4057qib7 470 7 , , , cord-005453-4057qib7 470 8 55.1 55.1 CD cord-005453-4057qib7 470 9 % % NN cord-005453-4057qib7 470 10 vs. vs. IN cord-005453-4057qib7 470 11 83.9 83.9 CD cord-005453-4057qib7 470 12 % % NN cord-005453-4057qib7 470 13 ) ) -RRB- cord-005453-4057qib7 470 14 and and CC cord-005453-4057qib7 471 1 relapsefree relapsefree NNP cord-005453-4057qib7 471 2 survival survival NNP cord-005453-4057qib7 471 3 ( ( -LRB- cord-005453-4057qib7 471 4 RFS RFS NNP cord-005453-4057qib7 471 5 , , , cord-005453-4057qib7 471 6 50.1 50.1 CD cord-005453-4057qib7 471 7 % % NN cord-005453-4057qib7 471 8 vs. vs. NN cord-005453-4057qib7 471 9 74.0 74.0 CD cord-005453-4057qib7 471 10 % % NN cord-005453-4057qib7 471 11 ) ) -RRB- cord-005453-4057qib7 471 12 rates rate NNS cord-005453-4057qib7 471 13 were be VBD cord-005453-4057qib7 471 14 both both DT cord-005453-4057qib7 471 15 similar similar JJ cord-005453-4057qib7 471 16 between between IN cord-005453-4057qib7 471 17 HID HID NNP cord-005453-4057qib7 471 18 - - HYPH cord-005453-4057qib7 471 19 SCT SCT NNP cord-005453-4057qib7 471 20 group group NN cord-005453-4057qib7 471 21 and and CC cord-005453-4057qib7 471 22 MSD MSD NNP cord-005453-4057qib7 471 23 - - HYPH cord-005453-4057qib7 471 24 SCT SCT NNP cord-005453-4057qib7 471 25 group group NN cord-005453-4057qib7 471 26 ( ( -LRB- cord-005453-4057qib7 471 27 p>0.05 p>0.05 NNP cord-005453-4057qib7 471 28 ) ) -RRB- cord-005453-4057qib7 471 29 . . . cord-005453-4057qib7 472 1 In in IN cord-005453-4057qib7 472 2 multivariate multivariate JJ cord-005453-4057qib7 472 3 analyses analysis NNS cord-005453-4057qib7 472 4 , , , cord-005453-4057qib7 472 5 non non JJ cord-005453-4057qib7 472 6 - - JJ cord-005453-4057qib7 472 7 remission remission JJ cord-005453-4057qib7 472 8 status status NN cord-005453-4057qib7 473 1 prior prior RB cord-005453-4057qib7 473 2 to to IN cord-005453-4057qib7 473 3 transplant transplant NN cord-005453-4057qib7 473 4 , , , cord-005453-4057qib7 473 5 poor poor JJ cord-005453-4057qib7 473 6 - - HYPH cord-005453-4057qib7 473 7 risk risk NN cord-005453-4057qib7 473 8 gene gene NN cord-005453-4057qib7 473 9 mutations mutation NNS cord-005453-4057qib7 473 10 and and CC cord-005453-4057qib7 473 11 donor donor NN cord-005453-4057qib7 473 12 's 's POS cord-005453-4057qib7 473 13 age age NN cord-005453-4057qib7 473 14 ≥ ≥ CD cord-005453-4057qib7 473 15 48 48 CD cord-005453-4057qib7 473 16 years year NNS cord-005453-4057qib7 473 17 predicted predict VBD cord-005453-4057qib7 473 18 a a DT cord-005453-4057qib7 473 19 higher high JJR cord-005453-4057qib7 473 20 risk risk NN cord-005453-4057qib7 473 21 of of IN cord-005453-4057qib7 473 22 relapse relapse NN cord-005453-4057qib7 473 23 after after IN cord-005453-4057qib7 473 24 DLI DLI NNP cord-005453-4057qib7 473 25 . . . cord-005453-4057qib7 474 1 Nonremission nonremission NN cord-005453-4057qib7 474 2 status status NN cord-005453-4057qib7 474 3 prior prior RB cord-005453-4057qib7 474 4 to to IN cord-005453-4057qib7 474 5 transplant transplant NN cord-005453-4057qib7 474 6 predicted predict VBD cord-005453-4057qib7 474 7 inferior inferior JJ cord-005453-4057qib7 474 8 OS OS NNP cord-005453-4057qib7 474 9 and and CC cord-005453-4057qib7 474 10 RFS RFS NNP cord-005453-4057qib7 474 11 . . . cord-005453-4057qib7 475 1 Patient Patient NNP cord-005453-4057qib7 475 2 's 's POS cord-005453-4057qib7 475 3 age age NN cord-005453-4057qib7 475 4 ≥ ≥ CD cord-005453-4057qib7 475 5 40 40 CD cord-005453-4057qib7 475 6 years year NNS cord-005453-4057qib7 475 7 also also RB cord-005453-4057qib7 475 8 predicted predict VBD cord-005453-4057qib7 475 9 an an DT cord-005453-4057qib7 475 10 inferior inferior JJ cord-005453-4057qib7 475 11 OS os NN cord-005453-4057qib7 475 12 . . . cord-005453-4057qib7 476 1 Conclusions conclusion NNS cord-005453-4057qib7 476 2 : : : cord-005453-4057qib7 477 1 Prophylactic prophylactic JJ cord-005453-4057qib7 477 2 DLI DLI NNP cord-005453-4057qib7 477 3 after after IN cord-005453-4057qib7 477 4 HID HID NNP cord-005453-4057qib7 477 5 - - HYPH cord-005453-4057qib7 477 6 SCT SCT NNP cord-005453-4057qib7 477 7 demonstrated demonstrate VBD cord-005453-4057qib7 477 8 similar similar JJ cord-005453-4057qib7 477 9 tolerance tolerance NN cord-005453-4057qib7 477 10 and and CC cord-005453-4057qib7 477 11 efficacy efficacy NN cord-005453-4057qib7 477 12 for for IN cord-005453-4057qib7 477 13 reducing reduce VBG cord-005453-4057qib7 477 14 relapse relapse NN cord-005453-4057qib7 477 15 compared compare VBN cord-005453-4057qib7 477 16 to to IN cord-005453-4057qib7 477 17 that that DT cord-005453-4057qib7 477 18 after after IN cord-005453-4057qib7 477 19 MSD MSD NNP cord-005453-4057qib7 477 20 - - HYPH cord-005453-4057qib7 477 21 SCT SCT NNP cord-005453-4057qib7 477 22 for for IN cord-005453-4057qib7 477 23 very very RB cord-005453-4057qib7 477 24 high high JJ cord-005453-4057qib7 477 25 - - HYPH cord-005453-4057qib7 477 26 risk risk NN cord-005453-4057qib7 477 27 AML AML NNP cord-005453-4057qib7 477 28 . . . cord-005453-4057qib7 478 1 Disclosure disclosure NN cord-005453-4057qib7 478 2 : : : cord-005453-4057qib7 479 1 The the DT cord-005453-4057qib7 479 2 authors author NNS cord-005453-4057qib7 479 3 declare declare VBP cord-005453-4057qib7 479 4 no no DT cord-005453-4057qib7 479 5 conflict conflict NN cord-005453-4057qib7 479 6 of of IN cord-005453-4057qib7 479 7 interest interest NN cord-005453-4057qib7 479 8 . . . cord-005453-4057qib7 480 1 Prognostic prognostic JJ cord-005453-4057qib7 480 2 impact impact NN cord-005453-4057qib7 480 3 of of IN cord-005453-4057qib7 480 4 pre pre JJ cord-005453-4057qib7 480 5 - - JJ cord-005453-4057qib7 480 6 transplant transplant JJ cord-005453-4057qib7 480 7 TIM3 TIM3 NNP cord-005453-4057qib7 480 8 levels level NNS cord-005453-4057qib7 480 9 on on IN cord-005453-4057qib7 480 10 transplant transplant NN cord-005453-4057qib7 480 11 outcome outcome NN cord-005453-4057qib7 480 12 in in IN cord-005453-4057qib7 480 13 acute acute JJ cord-005453-4057qib7 480 14 leukemia leukemia NN cord-005453-4057qib7 480 15 patients patient NNS cord-005453-4057qib7 481 1 Background background NN cord-005453-4057qib7 481 2 : : : cord-005453-4057qib7 481 3 T t NN cord-005453-4057qib7 481 4 cell cell NN cord-005453-4057qib7 481 5 immunoglobulin immunoglobulin NN cord-005453-4057qib7 481 6 and and CC cord-005453-4057qib7 481 7 mucin mucin NN cord-005453-4057qib7 481 8 domaincontaining domaincontaining NN cord-005453-4057qib7 481 9 protein-3 protein-3 NNP cord-005453-4057qib7 482 1 ( ( -LRB- cord-005453-4057qib7 482 2 TIM3 TIM3 NNP cord-005453-4057qib7 482 3 ) ) -RRB- cord-005453-4057qib7 482 4 , , , cord-005453-4057qib7 482 5 a a DT cord-005453-4057qib7 482 6 negative negative JJ cord-005453-4057qib7 482 7 regulator regulator NN cord-005453-4057qib7 482 8 of of IN cord-005453-4057qib7 482 9 T T NNP cord-005453-4057qib7 482 10 cells cell NNS cord-005453-4057qib7 482 11 , , , cord-005453-4057qib7 482 12 is be VBZ cord-005453-4057qib7 482 13 expressed express VBN cord-005453-4057qib7 482 14 on on IN cord-005453-4057qib7 482 15 a a DT cord-005453-4057qib7 482 16 variety variety NN cord-005453-4057qib7 482 17 of of IN cord-005453-4057qib7 482 18 tumors tumor NNS cord-005453-4057qib7 482 19 including include VBG cord-005453-4057qib7 482 20 hematological hematological JJ cord-005453-4057qib7 482 21 malignancies malignancy NNS cord-005453-4057qib7 482 22 like like IN cord-005453-4057qib7 482 23 acute acute JJ cord-005453-4057qib7 482 24 myeloid myeloid NN cord-005453-4057qib7 482 25 leukemia leukemia NN cord-005453-4057qib7 482 26 ( ( -LRB- cord-005453-4057qib7 482 27 AML AML NNP cord-005453-4057qib7 482 28 ) ) -RRB- cord-005453-4057qib7 482 29 and and CC cord-005453-4057qib7 482 30 some some DT cord-005453-4057qib7 482 31 lymphoma lymphoma NN cord-005453-4057qib7 482 32 types type NNS cord-005453-4057qib7 482 33 in in IN cord-005453-4057qib7 482 34 which which WDT cord-005453-4057qib7 482 35 it -PRON- PRP cord-005453-4057qib7 482 36 was be VBD cord-005453-4057qib7 482 37 shown show VBN cord-005453-4057qib7 482 38 to to TO cord-005453-4057qib7 482 39 be be VB cord-005453-4057qib7 482 40 associated associate VBN cord-005453-4057qib7 482 41 with with IN cord-005453-4057qib7 482 42 an an DT cord-005453-4057qib7 482 43 adverse adverse JJ cord-005453-4057qib7 482 44 prognosis prognosis NN cord-005453-4057qib7 482 45 . . . cord-005453-4057qib7 483 1 The the DT cord-005453-4057qib7 483 2 aim aim NN cord-005453-4057qib7 483 3 of of IN cord-005453-4057qib7 483 4 this this DT cord-005453-4057qib7 483 5 study study NN cord-005453-4057qib7 483 6 is be VBZ cord-005453-4057qib7 483 7 to to TO cord-005453-4057qib7 483 8 identify identify VB cord-005453-4057qib7 483 9 the the DT cord-005453-4057qib7 483 10 prognostic prognostic JJ cord-005453-4057qib7 483 11 impact impact NN cord-005453-4057qib7 483 12 of of IN cord-005453-4057qib7 483 13 pre pre JJ cord-005453-4057qib7 483 14 - - JJ cord-005453-4057qib7 483 15 transplant transplant JJ cord-005453-4057qib7 483 16 TIM3 TIM3 NNP cord-005453-4057qib7 483 17 levels level NNS cord-005453-4057qib7 483 18 on on IN cord-005453-4057qib7 483 19 early early JJ cord-005453-4057qib7 483 20 and and CC cord-005453-4057qib7 483 21 late late JJ cord-005453-4057qib7 483 22 transplant transplant NN cord-005453-4057qib7 483 23 related relate VBN cord-005453-4057qib7 483 24 complications complication NNS cord-005453-4057qib7 483 25 as as RB cord-005453-4057qib7 483 26 well well RB cord-005453-4057qib7 483 27 as as IN cord-005453-4057qib7 483 28 post post JJ cord-005453-4057qib7 483 29 - - JJ cord-005453-4057qib7 483 30 transplant transplant JJ cord-005453-4057qib7 483 31 relapse relapse NN cord-005453-4057qib7 483 32 and and CC cord-005453-4057qib7 483 33 survival survival NN cord-005453-4057qib7 483 34 Methods method NNS cord-005453-4057qib7 483 35 : : : cord-005453-4057qib7 483 36 A a DT cord-005453-4057qib7 483 37 total total NN cord-005453-4057qib7 483 38 of of IN cord-005453-4057qib7 483 39 177 177 CD cord-005453-4057qib7 483 40 hematopoietic hematopoietic JJ cord-005453-4057qib7 483 41 stem stem NN cord-005453-4057qib7 483 42 cell cell NN cord-005453-4057qib7 483 43 transplantation transplantation NN cord-005453-4057qib7 483 44 ( ( -LRB- cord-005453-4057qib7 483 45 HSCT HSCT NNP cord-005453-4057qib7 483 46 ) ) -RRB- cord-005453-4057qib7 483 47 recipients recipient NNS cord-005453-4057qib7 483 48 with with IN cord-005453-4057qib7 483 49 an an DT cord-005453-4057qib7 483 50 initial initial JJ cord-005453-4057qib7 483 51 diagnosis diagnosis NN cord-005453-4057qib7 483 52 of of IN cord-005453-4057qib7 483 53 acute acute JJ cord-005453-4057qib7 483 54 leukemia leukemia NN cord-005453-4057qib7 483 55 [ [ -LRB- cord-005453-4057qib7 483 56 median median NN cord-005453-4057qib7 483 57 age age NN cord-005453-4057qib7 483 58 : : : cord-005453-4057qib7 483 59 36(16 36(16 CD cord-005453-4057qib7 483 60 - - SYM cord-005453-4057qib7 483 61 66 66 CD cord-005453-4057qib7 483 62 ) ) -RRB- cord-005453-4057qib7 483 63 years year NNS cord-005453-4057qib7 483 64 ; ; , cord-005453-4057qib7 483 65 male/ male/ CD cord-005453-4057qib7 483 66 female female NN cord-005453-4057qib7 483 67 : : : cord-005453-4057qib7 483 68 111/66 111/66 CD cord-005453-4057qib7 483 69 ] ] -RRB- cord-005453-4057qib7 483 70 were be VBD cord-005453-4057qib7 483 71 included include VBN cord-005453-4057qib7 483 72 in in IN cord-005453-4057qib7 483 73 the the DT cord-005453-4057qib7 483 74 study study NN cord-005453-4057qib7 483 75 . . . cord-005453-4057qib7 484 1 AML AML NNP cord-005453-4057qib7 484 2 was be VBD cord-005453-4057qib7 484 3 the the DT cord-005453-4057qib7 484 4 initial initial JJ cord-005453-4057qib7 484 5 diagnosis diagnosis NN cord-005453-4057qib7 484 6 in in IN cord-005453-4057qib7 484 7 99 99 CD cord-005453-4057qib7 484 8 patients patient NNS cord-005453-4057qib7 484 9 ( ( -LRB- cord-005453-4057qib7 484 10 55.9 55.9 CD cord-005453-4057qib7 484 11 % % NN cord-005453-4057qib7 484 12 ) ) -RRB- cord-005453-4057qib7 484 13 , , , cord-005453-4057qib7 484 14 acute acute JJ cord-005453-4057qib7 484 15 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 484 16 leukemia leukemia NN cord-005453-4057qib7 484 17 ( ( -LRB- cord-005453-4057qib7 484 18 ALL all DT cord-005453-4057qib7 484 19 ) ) -RRB- cord-005453-4057qib7 484 20 in in IN cord-005453-4057qib7 484 21 74 74 CD cord-005453-4057qib7 484 22 patients patient NNS cord-005453-4057qib7 484 23 ( ( -LRB- cord-005453-4057qib7 484 24 41.8 41.8 CD cord-005453-4057qib7 484 25 % % NN cord-005453-4057qib7 484 26 ) ) -RRB- cord-005453-4057qib7 484 27 , , , cord-005453-4057qib7 484 28 mixed mixed JJ cord-005453-4057qib7 484 29 phenotype phenotype NN cord-005453-4057qib7 484 30 acute acute JJ cord-005453-4057qib7 484 31 leukemia leukemia NN cord-005453-4057qib7 484 32 in in IN cord-005453-4057qib7 484 33 3 3 CD cord-005453-4057qib7 484 34 patients patient NNS cord-005453-4057qib7 484 35 ( ( -LRB- cord-005453-4057qib7 484 36 1.7 1.7 CD cord-005453-4057qib7 484 37 % % NN cord-005453-4057qib7 484 38 ) ) -RRB- cord-005453-4057qib7 484 39 and and CC cord-005453-4057qib7 484 40 blastic blastic JJ cord-005453-4057qib7 484 41 plasmacytoid plasmacytoid NNP cord-005453-4057qib7 484 42 dendritic dendritic JJ cord-005453-4057qib7 484 43 cell cell NN cord-005453-4057qib7 484 44 neoplasm neoplasm NN cord-005453-4057qib7 484 45 in in IN cord-005453-4057qib7 484 46 1 1 CD cord-005453-4057qib7 484 47 patient patient NN cord-005453-4057qib7 484 48 ( ( -LRB- cord-005453-4057qib7 484 49 0.6 0.6 CD cord-005453-4057qib7 484 50 % % NN cord-005453-4057qib7 484 51 ) ) -RRB- cord-005453-4057qib7 484 52 . . . cord-005453-4057qib7 485 1 Soluble soluble JJ cord-005453-4057qib7 485 2 TIM-3 tim-3 JJ cord-005453-4057qib7 485 3 levels level NNS cord-005453-4057qib7 485 4 in in IN cord-005453-4057qib7 485 5 pre pre JJ cord-005453-4057qib7 485 6 - - JJ cord-005453-4057qib7 485 7 transplant transplant JJ cord-005453-4057qib7 485 8 serum serum NN cord-005453-4057qib7 485 9 samples sample NNS cord-005453-4057qib7 485 10 were be VBD cord-005453-4057qib7 485 11 measured measure VBN cord-005453-4057qib7 485 12 with with IN cord-005453-4057qib7 485 13 Enzyme Enzyme NNP cord-005453-4057qib7 485 14 Linked link VBN cord-005453-4057qib7 485 15 Immunosorbent Immunosorbent NNP cord-005453-4057qib7 485 16 Assay Assay NNP cord-005453-4057qib7 485 17 ( ( -LRB- cord-005453-4057qib7 485 18 ELISA ELISA NNP cord-005453-4057qib7 485 19 ) ) -RRB- cord-005453-4057qib7 485 20 . . . cord-005453-4057qib7 486 1 Results result NNS cord-005453-4057qib7 486 2 : : : cord-005453-4057qib7 487 1 Median median JJ cord-005453-4057qib7 487 2 pre pre JJ cord-005453-4057qib7 487 3 - - JJ cord-005453-4057qib7 487 4 transplant transplant JJ cord-005453-4057qib7 487 5 TIM3 TIM3 NNP cord-005453-4057qib7 487 6 level level NN cord-005453-4057qib7 487 7 was be VBD cord-005453-4057qib7 487 8 955.6 955.6 CD cord-005453-4057qib7 487 9 ( ( -LRB- cord-005453-4057qib7 487 10 65.8 65.8 CD cord-005453-4057qib7 487 11 - - HYPH cord-005453-4057qib7 487 12 3784.4 3784.4 CD cord-005453-4057qib7 487 13 ) ) -RRB- cord-005453-4057qib7 488 1 pg pg NNP cord-005453-4057qib7 488 2 / / SYM cord-005453-4057qib7 488 3 mL ml NN cord-005453-4057qib7 488 4 in in IN cord-005453-4057qib7 488 5 the the DT cord-005453-4057qib7 488 6 whole whole JJ cord-005453-4057qib7 488 7 cohort cohort NN cord-005453-4057qib7 488 8 . . . cord-005453-4057qib7 489 1 Pre pre JJ cord-005453-4057qib7 489 2 - - JJ cord-005453-4057qib7 489 3 transplant transplant NN cord-005453-4057qib7 489 4 TIM3 TIM3 NNP cord-005453-4057qib7 489 5 levels level NNS cord-005453-4057qib7 489 6 were be VBD cord-005453-4057qib7 489 7 significantly significantly RB cord-005453-4057qib7 489 8 higher high JJR cord-005453-4057qib7 489 9 in in IN cord-005453-4057qib7 489 10 AML AML NNP cord-005453-4057qib7 489 11 patients patient NNS cord-005453-4057qib7 489 12 when when WRB cord-005453-4057qib7 489 13 compared compare VBN cord-005453-4057qib7 489 14 to to IN cord-005453-4057qib7 489 15 ALL all DT cord-005453-4057qib7 489 16 [ [ -LRB- cord-005453-4057qib7 489 17 1063.7(409.5 1063.7(409.5 CD cord-005453-4057qib7 489 18 - - HYPH cord-005453-4057qib7 489 19 3784.4 3784.4 CD cord-005453-4057qib7 489 20 ) ) -RRB- cord-005453-4057qib7 489 21 vs vs IN cord-005453-4057qib7 489 22 831.4 831.4 CD cord-005453-4057qib7 489 23 ( ( -LRB- cord-005453-4057qib7 489 24 65.8 65.8 CD cord-005453-4057qib7 489 25 - - HYPH cord-005453-4057qib7 489 26 3254.4 3254.4 CD cord-005453-4057qib7 489 27 ) ) -RRB- cord-005453-4057qib7 489 28 ; ; : cord-005453-4057qib7 489 29 p=0.01 p=0.01 NNP cord-005453-4057qib7 489 30 ] ] -RRB- cord-005453-4057qib7 489 31 . . . cord-005453-4057qib7 490 1 TIM3 tim3 JJ cord-005453-4057qib7 490 2 levels level NNS cord-005453-4057qib7 490 3 were be VBD cord-005453-4057qib7 490 4 significantly significantly RB cord-005453-4057qib7 490 5 lower low JJR cord-005453-4057qib7 490 6 in in IN cord-005453-4057qib7 490 7 patients patient NNS cord-005453-4057qib7 490 8 with with IN cord-005453-4057qib7 490 9 abnormal abnormal JJ cord-005453-4057qib7 490 10 cytogenetics cytogenetic NNS cord-005453-4057qib7 490 11 when when WRB cord-005453-4057qib7 490 12 compared compare VBN cord-005453-4057qib7 490 13 to to IN cord-005453-4057qib7 490 14 normal normal JJ cord-005453-4057qib7 490 15 karyotype karyotype NN cord-005453-4057qib7 490 16 ( ( -LRB- cord-005453-4057qib7 490 17 p=0.017 p=0.017 NNS cord-005453-4057qib7 490 18 ) ) -RRB- cord-005453-4057qib7 490 19 . . . cord-005453-4057qib7 491 1 Cytogenetic cytogenetic JJ cord-005453-4057qib7 491 2 abnormalities abnormality NNS cord-005453-4057qib7 491 3 , , , cord-005453-4057qib7 491 4 including include VBG cord-005453-4057qib7 491 5 mainly mainly RB cord-005453-4057qib7 491 6 a a DT cord-005453-4057qib7 491 7 complex complex JJ cord-005453-4057qib7 491 8 karyotype karyotype NN cord-005453-4057qib7 491 9 or or CC cord-005453-4057qib7 491 10 chromosome chromosome NN cord-005453-4057qib7 491 11 8 8 CD cord-005453-4057qib7 491 12 abnormalities abnormality NNS cord-005453-4057qib7 491 13 , , , cord-005453-4057qib7 491 14 were be VBD cord-005453-4057qib7 491 15 more more RBR cord-005453-4057qib7 491 16 frequent frequent JJ cord-005453-4057qib7 491 17 in in IN cord-005453-4057qib7 491 18 patients patient NNS cord-005453-4057qib7 491 19 with with IN cord-005453-4057qib7 491 20 low low JJ cord-005453-4057qib7 491 21 TIM3 tim3 JJ cord-005453-4057qib7 491 22 levels level NNS cord-005453-4057qib7 491 23 ( ( -LRB- cord-005453-4057qib7 491 24 p=0.053 p=0.053 NN cord-005453-4057qib7 491 25 ) ) -RRB- cord-005453-4057qib7 491 26 . . . cord-005453-4057qib7 492 1 Pre pre JJ cord-005453-4057qib7 492 2 - - JJ cord-005453-4057qib7 492 3 transplant transplant NN cord-005453-4057qib7 492 4 TIM3 TIM3 NNP cord-005453-4057qib7 492 5 levels level NNS cord-005453-4057qib7 492 6 were be VBD cord-005453-4057qib7 492 7 significantly significantly RB cord-005453-4057qib7 492 8 higher high JJR cord-005453-4057qib7 492 9 in in IN cord-005453-4057qib7 492 10 patients patient NNS cord-005453-4057qib7 492 11 who who WP cord-005453-4057qib7 492 12 developed develop VBD cord-005453-4057qib7 492 13 post post JJ cord-005453-4057qib7 492 14 - - JJ cord-005453-4057qib7 492 15 transplant transplant JJ cord-005453-4057qib7 492 16 viral viral JJ cord-005453-4057qib7 492 17 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 492 18 cystitis cystitis NN cord-005453-4057qib7 492 19 ( ( -LRB- cord-005453-4057qib7 492 20 p=0.034 p=0.034 NNP cord-005453-4057qib7 492 21 ) ) -RRB- cord-005453-4057qib7 492 22 . . . cord-005453-4057qib7 493 1 A a DT cord-005453-4057qib7 493 2 positive positive JJ cord-005453-4057qib7 493 3 correlation correlation NN cord-005453-4057qib7 493 4 was be VBD cord-005453-4057qib7 493 5 demonstrated demonstrate VBN cord-005453-4057qib7 493 6 between between IN cord-005453-4057qib7 493 7 TIM3 TIM3 NNP cord-005453-4057qib7 493 8 levels level NNS cord-005453-4057qib7 493 9 and and CC cord-005453-4057qib7 493 10 acute acute JJ cord-005453-4057qib7 493 11 graft graft NN cord-005453-4057qib7 493 12 versus versus IN cord-005453-4057qib7 493 13 host host NN cord-005453-4057qib7 493 14 disease disease NN cord-005453-4057qib7 493 15 ( ( -LRB- cord-005453-4057qib7 493 16 GvHD GvHD NNP cord-005453-4057qib7 493 17 ) ) -RRB- cord-005453-4057qib7 493 18 grade grade NN cord-005453-4057qib7 493 19 ( ( -LRB- cord-005453-4057qib7 493 20 p=0.013 p=0.013 NN cord-005453-4057qib7 493 21 ; ; : cord-005453-4057qib7 493 22 r=0.299 r=0.299 ADD cord-005453-4057qib7 493 23 ) ) -RRB- cord-005453-4057qib7 493 24 . . . cord-005453-4057qib7 494 1 At at IN cord-005453-4057qib7 494 2 a a DT cord-005453-4057qib7 494 3 median median JJ cord-005453-4057qib7 494 4 follow follow NN cord-005453-4057qib7 494 5 - - HYPH cord-005453-4057qib7 494 6 up up NN cord-005453-4057qib7 494 7 of of IN cord-005453-4057qib7 494 8 14.6 14.6 CD cord-005453-4057qib7 494 9 ( ( -LRB- cord-005453-4057qib7 494 10 0.2 0.2 CD cord-005453-4057qib7 494 11 - - SYM cord-005453-4057qib7 494 12 160.9 160.9 CD cord-005453-4057qib7 494 13 ) ) -RRB- cord-005453-4057qib7 494 14 months month NNS cord-005453-4057qib7 494 15 , , , cord-005453-4057qib7 494 16 overall overall JJ cord-005453-4057qib7 494 17 survival survival NN cord-005453-4057qib7 494 18 ( ( -LRB- cord-005453-4057qib7 494 19 OS OS NNP cord-005453-4057qib7 494 20 ) ) -RRB- cord-005453-4057qib7 494 21 was be VBD cord-005453-4057qib7 494 22 found find VBN cord-005453-4057qib7 494 23 to to TO cord-005453-4057qib7 494 24 be be VB cord-005453-4057qib7 494 25 better well JJR cord-005453-4057qib7 494 26 in in IN cord-005453-4057qib7 494 27 low low JJ cord-005453-4057qib7 494 28 - - HYPH cord-005453-4057qib7 494 29 TIM3 tim3 JJ cord-005453-4057qib7 494 30 group group NN cord-005453-4057qib7 494 31 when when WRB cord-005453-4057qib7 494 32 compared compare VBN cord-005453-4057qib7 494 33 to to IN cord-005453-4057qib7 494 34 high high JJ cord-005453-4057qib7 494 35 - - HYPH cord-005453-4057qib7 494 36 TIM3 tim3 JJ cord-005453-4057qib7 494 37 group group NN cord-005453-4057qib7 494 38 , , , cord-005453-4057qib7 494 39 without without IN cord-005453-4057qib7 494 40 statistical statistical JJ cord-005453-4057qib7 494 41 significance significance NN cord-005453-4057qib7 494 42 ( ( -LRB- cord-005453-4057qib7 494 43 % % NN cord-005453-4057qib7 494 44 35.2 35.2 CD cord-005453-4057qib7 494 45 vs vs IN cord-005453-4057qib7 494 46 % % NN cord-005453-4057qib7 494 47 20.4 20.4 CD cord-005453-4057qib7 494 48 ; ; : cord-005453-4057qib7 494 49 p>0.05 p>0.05 NNP cord-005453-4057qib7 494 50 ) ) -RRB- cord-005453-4057qib7 495 1 ( ( -LRB- cord-005453-4057qib7 495 2 Figure figure NN cord-005453-4057qib7 495 3 1 1 CD cord-005453-4057qib7 495 4 ) ) -RRB- cord-005453-4057qib7 495 5 . . . cord-005453-4057qib7 496 1 Probability probability NN cord-005453-4057qib7 496 2 of of IN cord-005453-4057qib7 496 3 OS OS NNP cord-005453-4057qib7 496 4 was be VBD cord-005453-4057qib7 496 5 relatively relatively RB cord-005453-4057qib7 496 6 better well JJR cord-005453-4057qib7 496 7 in in IN cord-005453-4057qib7 496 8 both both CC cord-005453-4057qib7 496 9 AML AML NNP cord-005453-4057qib7 496 10 ( ( -LRB- cord-005453-4057qib7 496 11 42.6 42.6 CD cord-005453-4057qib7 496 12 % % NN cord-005453-4057qib7 496 13 vs vs IN cord-005453-4057qib7 496 14 26.7 26.7 CD cord-005453-4057qib7 496 15 % % NN cord-005453-4057qib7 496 16 ; ; : cord-005453-4057qib7 496 17 p>0.05 p>0.05 NNP cord-005453-4057qib7 496 18 ) ) -RRB- cord-005453-4057qib7 496 19 and and CC cord-005453-4057qib7 496 20 ALL all DT cord-005453-4057qib7 496 21 patients patient NNS cord-005453-4057qib7 496 22 ( ( -LRB- cord-005453-4057qib7 496 23 29.5 29.5 CD cord-005453-4057qib7 496 24 % % NN cord-005453-4057qib7 496 25 vs vs IN cord-005453-4057qib7 496 26 19 19 CD cord-005453-4057qib7 496 27 % % NN cord-005453-4057qib7 496 28 ; ; : cord-005453-4057qib7 496 29 p>0.05 p>0.05 NNP cord-005453-4057qib7 496 30 ) ) -RRB- cord-005453-4057qib7 496 31 representing represent VBG cord-005453-4057qib7 496 32 low low JJ cord-005453-4057qib7 496 33 pretransplant pretransplant NN cord-005453-4057qib7 496 34 TIM3 TIM3 NNP cord-005453-4057qib7 496 35 levels level NNS cord-005453-4057qib7 496 36 in in IN cord-005453-4057qib7 496 37 the the DT cord-005453-4057qib7 496 38 subgroup subgroup NN cord-005453-4057qib7 496 39 analysis analysis NN cord-005453-4057qib7 496 40 Conclusions conclusion NNS cord-005453-4057qib7 496 41 : : : cord-005453-4057qib7 497 1 In in IN cord-005453-4057qib7 497 2 this this DT cord-005453-4057qib7 497 3 study study NN cord-005453-4057qib7 497 4 , , , cord-005453-4057qib7 497 5 elevated elevated JJ cord-005453-4057qib7 497 6 levels level NNS cord-005453-4057qib7 497 7 of of IN cord-005453-4057qib7 497 8 pretransplant pretransplant JJ cord-005453-4057qib7 497 9 TIM3 TIM3 NNP cord-005453-4057qib7 497 10 levels level NNS cord-005453-4057qib7 497 11 in in IN cord-005453-4057qib7 497 12 AML AML NNP cord-005453-4057qib7 497 13 patients patient NNS cord-005453-4057qib7 497 14 were be VBD cord-005453-4057qib7 497 15 compatible compatible JJ cord-005453-4057qib7 497 16 with with IN cord-005453-4057qib7 497 17 the the DT cord-005453-4057qib7 497 18 previous previous JJ cord-005453-4057qib7 497 19 reports report NNS cord-005453-4057qib7 497 20 which which WDT cord-005453-4057qib7 497 21 had have VBD cord-005453-4057qib7 497 22 underlined underline VBN cord-005453-4057qib7 497 23 an an DT cord-005453-4057qib7 497 24 increased increase VBN cord-005453-4057qib7 497 25 TIM3 TIM3 NNP cord-005453-4057qib7 497 26 expression expression NN cord-005453-4057qib7 497 27 on on IN cord-005453-4057qib7 497 28 AML AML NNP cord-005453-4057qib7 497 29 stem stem NN cord-005453-4057qib7 497 30 cells cell NNS cord-005453-4057qib7 497 31 . . . cord-005453-4057qib7 498 1 The the DT cord-005453-4057qib7 498 2 possible possible JJ cord-005453-4057qib7 498 3 association association NN cord-005453-4057qib7 498 4 of of IN cord-005453-4057qib7 498 5 TIM3 TIM3 NNP cord-005453-4057qib7 498 6 expression expression NN cord-005453-4057qib7 498 7 with with IN cord-005453-4057qib7 498 8 cytogenetic cytogenetic JJ cord-005453-4057qib7 498 9 features feature NNS cord-005453-4057qib7 498 10 should should MD cord-005453-4057qib7 498 11 be be VB cord-005453-4057qib7 498 12 confirmed confirm VBN cord-005453-4057qib7 498 13 with with IN cord-005453-4057qib7 498 14 further further JJ cord-005453-4057qib7 498 15 studies study NNS cord-005453-4057qib7 498 16 as as IN cord-005453-4057qib7 498 17 there there EX cord-005453-4057qib7 498 18 is be VBZ cord-005453-4057qib7 498 19 no no DT cord-005453-4057qib7 498 20 adequate adequate JJ cord-005453-4057qib7 498 21 data datum NNS cord-005453-4057qib7 498 22 except except IN cord-005453-4057qib7 498 23 its -PRON- PRP$ cord-005453-4057qib7 498 24 relationship relationship NN cord-005453-4057qib7 498 25 with with IN cord-005453-4057qib7 498 26 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 498 27 mutational mutational JJ cord-005453-4057qib7 498 28 status status NN cord-005453-4057qib7 498 29 . . . cord-005453-4057qib7 499 1 TIM-3 tim-3 JJ cord-005453-4057qib7 499 2 is be VBZ cord-005453-4057qib7 499 3 also also RB cord-005453-4057qib7 499 4 expressed express VBN cord-005453-4057qib7 499 5 on on IN cord-005453-4057qib7 499 6 exhausted exhaust VBN cord-005453-4057qib7 499 7 T t NN cord-005453-4057qib7 499 8 cells cell NNS cord-005453-4057qib7 499 9 in in IN cord-005453-4057qib7 499 10 patients patient NNS cord-005453-4057qib7 499 11 with with IN cord-005453-4057qib7 499 12 viral viral JJ cord-005453-4057qib7 499 13 infections infection NNS cord-005453-4057qib7 499 14 , , , cord-005453-4057qib7 499 15 including include VBG cord-005453-4057qib7 499 16 human human JJ cord-005453-4057qib7 499 17 immunodeficiency immunodeficiency NN cord-005453-4057qib7 499 18 virus virus NN cord-005453-4057qib7 499 19 , , , cord-005453-4057qib7 499 20 hepatitis hepatitis NNP cord-005453-4057qib7 499 21 B B NNP cord-005453-4057qib7 499 22 and and CC cord-005453-4057qib7 499 23 hepatitis hepatitis NN cord-005453-4057qib7 499 24 C C NNP cord-005453-4057qib7 499 25 virus virus NN cord-005453-4057qib7 499 26 . . . cord-005453-4057qib7 500 1 It -PRON- PRP cord-005453-4057qib7 500 2 plays play VBZ cord-005453-4057qib7 500 3 an an DT cord-005453-4057qib7 500 4 essential essential JJ cord-005453-4057qib7 500 5 role role NN cord-005453-4057qib7 500 6 in in IN cord-005453-4057qib7 500 7 the the DT cord-005453-4057qib7 500 8 regulation regulation NN cord-005453-4057qib7 500 9 of of IN cord-005453-4057qib7 500 10 antiviral antiviral JJ cord-005453-4057qib7 500 11 and and CC cord-005453-4057qib7 500 12 antitumor antitumor JJ cord-005453-4057qib7 500 13 immune immune JJ cord-005453-4057qib7 500 14 responses response NNS cord-005453-4057qib7 500 15 which which WDT cord-005453-4057qib7 500 16 may may MD cord-005453-4057qib7 500 17 be be VB cord-005453-4057qib7 500 18 an an DT cord-005453-4057qib7 500 19 explanation explanation NN cord-005453-4057qib7 500 20 for for IN cord-005453-4057qib7 500 21 the the DT cord-005453-4057qib7 500 22 increased increase VBN cord-005453-4057qib7 500 23 frequency frequency NN cord-005453-4057qib7 500 24 of of IN cord-005453-4057qib7 500 25 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 500 26 cystitis cystitis NN cord-005453-4057qib7 500 27 in in IN cord-005453-4057qib7 500 28 patients patient NNS cord-005453-4057qib7 500 29 with with IN cord-005453-4057qib7 500 30 higher high JJR cord-005453-4057qib7 500 31 TIM-3 tim-3 JJ cord-005453-4057qib7 500 32 levels level NNS cord-005453-4057qib7 500 33 . . . cord-005453-4057qib7 501 1 The the DT cord-005453-4057qib7 501 2 adverse adverse JJ cord-005453-4057qib7 501 3 prognostic prognostic JJ cord-005453-4057qib7 501 4 impact impact NN cord-005453-4057qib7 501 5 of of IN cord-005453-4057qib7 501 6 TIM3 TIM3 NNP cord-005453-4057qib7 501 7 on on IN cord-005453-4057qib7 501 8 GvHD GvHD NNP cord-005453-4057qib7 501 9 and and CC cord-005453-4057qib7 501 10 OS OS NNP cord-005453-4057qib7 501 11 was be VBD cord-005453-4057qib7 501 12 confirmed confirm VBN cord-005453-4057qib7 501 13 without without IN cord-005453-4057qib7 501 14 statistical statistical JJ cord-005453-4057qib7 501 15 significance significance NN cord-005453-4057qib7 501 16 which which WDT cord-005453-4057qib7 501 17 may may MD cord-005453-4057qib7 501 18 be be VB cord-005453-4057qib7 501 19 related relate VBN cord-005453-4057qib7 501 20 to to IN cord-005453-4057qib7 501 21 small small JJ cord-005453-4057qib7 501 22 sample sample NN cord-005453-4057qib7 501 23 size size NN cord-005453-4057qib7 501 24 . . . cord-005453-4057qib7 502 1 As as IN cord-005453-4057qib7 502 2 TIM3 TIM3 NNP cord-005453-4057qib7 502 3 has have VBZ cord-005453-4057qib7 502 4 a a DT cord-005453-4057qib7 502 5 wide wide JJ cord-005453-4057qib7 502 6 spectrum spectrum NN cord-005453-4057qib7 502 7 of of IN cord-005453-4057qib7 502 8 action action NN cord-005453-4057qib7 502 9 in in IN cord-005453-4057qib7 502 10 the the DT cord-005453-4057qib7 502 11 tumor tumor NN cord-005453-4057qib7 502 12 microenvironment microenvironment NN cord-005453-4057qib7 502 13 including include VBG cord-005453-4057qib7 502 14 stimulatory stimulatory JJ cord-005453-4057qib7 502 15 and and CC cord-005453-4057qib7 502 16 inhibitory inhibitory JJ cord-005453-4057qib7 502 17 activities activity NNS cord-005453-4057qib7 502 18 , , , cord-005453-4057qib7 502 19 further further JJ cord-005453-4057qib7 502 20 clues clue NNS cord-005453-4057qib7 502 21 are be VBP cord-005453-4057qib7 502 22 required require VBN cord-005453-4057qib7 502 23 to to TO cord-005453-4057qib7 502 24 define define VB cord-005453-4057qib7 502 25 the the DT cord-005453-4057qib7 502 26 exact exact JJ cord-005453-4057qib7 502 27 role role NN cord-005453-4057qib7 502 28 of of IN cord-005453-4057qib7 502 29 this this DT cord-005453-4057qib7 502 30 molecule molecule NN cord-005453-4057qib7 502 31 in in IN cord-005453-4057qib7 502 32 the the DT cord-005453-4057qib7 502 33 clinical clinical JJ cord-005453-4057qib7 502 34 course course NN cord-005453-4057qib7 502 35 of of IN cord-005453-4057qib7 502 36 allogeneic allogeneic NN cord-005453-4057qib7 502 37 HSCT HSCT NNP cord-005453-4057qib7 502 38 in in IN cord-005453-4057qib7 502 39 order order NN cord-005453-4057qib7 502 40 to to TO cord-005453-4057qib7 502 41 develop develop VB cord-005453-4057qib7 502 42 targeted target VBN cord-005453-4057qib7 502 43 therapeutic therapeutic JJ cord-005453-4057qib7 502 44 strategies strategy NNS cord-005453-4057qib7 502 45 Clinical Clinical NNP cord-005453-4057qib7 502 46 Trial Trial NNP cord-005453-4057qib7 502 47 Registry Registry NNP cord-005453-4057qib7 502 48 : : : cord-005453-4057qib7 503 1 N N NNP cord-005453-4057qib7 503 2 / / SYM cord-005453-4057qib7 503 3 A a DT cord-005453-4057qib7 503 4 Disclosure disclosure NN cord-005453-4057qib7 503 5 : : : cord-005453-4057qib7 503 6 Nothing nothing NN cord-005453-4057qib7 503 7 to to TO cord-005453-4057qib7 503 8 declare declare VB cord-005453-4057qib7 503 9 P029 p029 PRP cord-005453-4057qib7 504 1 Homozygous Homozygous NNP cord-005453-4057qib7 504 2 HLA HLA NNP cord-005453-4057qib7 504 3 - - HYPH cord-005453-4057qib7 504 4 C1 C1 NNP cord-005453-4057qib7 504 5 is be VBZ cord-005453-4057qib7 504 6 associated associate VBN cord-005453-4057qib7 504 7 with with IN cord-005453-4057qib7 504 8 increased increase VBN cord-005453-4057qib7 504 9 risk risk NN cord-005453-4057qib7 504 10 of of IN cord-005453-4057qib7 504 11 relapse relapse NN cord-005453-4057qib7 504 12 after after IN cord-005453-4057qib7 504 13 HLA HLA NNP cord-005453-4057qib7 504 14 - - HYPH cord-005453-4057qib7 504 15 matched match VBN cord-005453-4057qib7 504 16 transplantation transplantation NN cord-005453-4057qib7 504 17 in in IN cord-005453-4057qib7 504 18 recipients recipient NNS cord-005453-4057qib7 504 19 with with IN cord-005453-4057qib7 504 20 acute acute JJ cord-005453-4057qib7 504 21 lymphoid lymphoid JJ cord-005453-4057qib7 504 22 leukemia leukemia NN cord-005453-4057qib7 504 23 : : : cord-005453-4057qib7 505 1 A a DT cord-005453-4057qib7 505 2 Japanese japanese JJ cord-005453-4057qib7 505 3 national national JJ cord-005453-4057qib7 505 4 registry registry NN cord-005453-4057qib7 505 5 study study NN cord-005453-4057qib7 505 6 Background background NN cord-005453-4057qib7 505 7 : : : cord-005453-4057qib7 506 1 After after IN cord-005453-4057qib7 506 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 506 3 stem stem NN cord-005453-4057qib7 506 4 cell cell NN cord-005453-4057qib7 506 5 transplantation transplantation NN cord-005453-4057qib7 506 6 ( ( -LRB- cord-005453-4057qib7 506 7 HSCT HSCT NNP cord-005453-4057qib7 506 8 ) ) -RRB- cord-005453-4057qib7 506 9 , , , cord-005453-4057qib7 506 10 the the DT cord-005453-4057qib7 506 11 role role NN cord-005453-4057qib7 506 12 of of IN cord-005453-4057qib7 506 13 natural natural JJ cord-005453-4057qib7 506 14 killer killer NN cord-005453-4057qib7 506 15 ( ( -LRB- cord-005453-4057qib7 506 16 NK NK NNP cord-005453-4057qib7 506 17 ) ) -RRB- cord-005453-4057qib7 506 18 cells cell NNS cord-005453-4057qib7 506 19 which which WDT cord-005453-4057qib7 506 20 express express VBP cord-005453-4057qib7 506 21 killer killer NN cord-005453-4057qib7 506 22 - - HYPH cord-005453-4057qib7 506 23 cells cell NNS cord-005453-4057qib7 506 24 immunoglobulin immunoglobulin NN cord-005453-4057qib7 506 25 - - HYPH cord-005453-4057qib7 506 26 like like JJ cord-005453-4057qib7 506 27 receptors receptor NNS cord-005453-4057qib7 506 28 ( ( -LRB- cord-005453-4057qib7 506 29 KIRs kir NNS cord-005453-4057qib7 506 30 ) ) -RRB- cord-005453-4057qib7 506 31 and and CC cord-005453-4057qib7 506 32 recognize recognize VB cord-005453-4057qib7 506 33 HLA HLA NNP cord-005453-4057qib7 506 34 - - HYPH cord-005453-4057qib7 506 35 class class NN cord-005453-4057qib7 506 36 1 1 CD cord-005453-4057qib7 506 37 ligands ligand NNS cord-005453-4057qib7 506 38 is be VBZ cord-005453-4057qib7 506 39 important important JJ cord-005453-4057qib7 506 40 . . . cord-005453-4057qib7 507 1 KIR2DL1 KIR2DL1 NNP cord-005453-4057qib7 507 2 recognizes recognize VBZ cord-005453-4057qib7 507 3 not not RB cord-005453-4057qib7 507 4 HLA HLA NNP cord-005453-4057qib7 507 5 - - HYPH cord-005453-4057qib7 507 6 C C NNP cord-005453-4057qib7 507 7 Asp80 Asp80 NNP cord-005453-4057qib7 507 8 ( ( -LRB- cord-005453-4057qib7 507 9 C1 C1 NNP cord-005453-4057qib7 507 10 ) ) -RRB- cord-005453-4057qib7 507 11 , , , cord-005453-4057qib7 507 12 but but CC cord-005453-4057qib7 508 1 HLA HLA NNP cord-005453-4057qib7 508 2 - - HYPH cord-005453-4057qib7 508 3 C C NNP cord-005453-4057qib7 508 4 Lys80 Lys80 NNP cord-005453-4057qib7 508 5 ( ( -LRB- cord-005453-4057qib7 508 6 C2 C2 NNP cord-005453-4057qib7 508 7 ) ) -RRB- cord-005453-4057qib7 508 8 and and CC cord-005453-4057qib7 508 9 has have VBZ cord-005453-4057qib7 508 10 polymorphism polymorphism NN cord-005453-4057qib7 508 11 based base VBN cord-005453-4057qib7 508 12 on on IN cord-005453-4057qib7 508 13 the the DT cord-005453-4057qib7 508 14 245 245 CD cord-005453-4057qib7 508 15 th th XX cord-005453-4057qib7 508 16 amino amino NN cord-005453-4057qib7 508 17 acid acid NN cord-005453-4057qib7 508 18 of of IN cord-005453-4057qib7 508 19 the the DT cord-005453-4057qib7 508 20 transmembrane transmembrane NN cord-005453-4057qib7 508 21 domain domain NN cord-005453-4057qib7 508 22 . . . cord-005453-4057qib7 509 1 Low low JJ cord-005453-4057qib7 509 2 frequency frequency NN cord-005453-4057qib7 509 3 of of IN cord-005453-4057qib7 509 4 C2 c2 NN cord-005453-4057qib7 509 5 and and CC cord-005453-4057qib7 509 6 high high JJ cord-005453-4057qib7 509 7 frequency frequency NN cord-005453-4057qib7 509 8 of of IN cord-005453-4057qib7 509 9 strong strong JJ cord-005453-4057qib7 509 10 KIR2DL1 KIR2DL1 NNP cord-005453-4057qib7 509 11 are be VBP cord-005453-4057qib7 509 12 characteristics characteristic NNS cord-005453-4057qib7 509 13 observed observe VBN cord-005453-4057qib7 509 14 in in IN cord-005453-4057qib7 509 15 Japanese Japanese NNP cord-005453-4057qib7 509 16 . . . cord-005453-4057qib7 510 1 By by IN cord-005453-4057qib7 510 2 using use VBG cord-005453-4057qib7 510 3 large large JJ cord-005453-4057qib7 510 4 transplant transplant NN cord-005453-4057qib7 510 5 database database NN cord-005453-4057qib7 510 6 , , , cord-005453-4057qib7 510 7 we -PRON- PRP cord-005453-4057qib7 510 8 reported report VBD cord-005453-4057qib7 510 9 that that IN cord-005453-4057qib7 510 10 homozygous homozygous JJ cord-005453-4057qib7 510 11 HLA HLA NNP cord-005453-4057qib7 510 12 - - HYPH cord-005453-4057qib7 510 13 C1 C1 NNP cord-005453-4057qib7 510 14 ( ( -LRB- cord-005453-4057qib7 510 15 C1 C1 NNP cord-005453-4057qib7 510 16 / / SYM cord-005453-4057qib7 510 17 C1 C1 NNP cord-005453-4057qib7 510 18 ) ) -RRB- cord-005453-4057qib7 510 19 recipients recipient NNS cord-005453-4057qib7 510 20 displayed display VBD cord-005453-4057qib7 510 21 lower low JJR cord-005453-4057qib7 510 22 relapse relapse NN cord-005453-4057qib7 510 23 rates rate NNS cord-005453-4057qib7 510 24 than than IN cord-005453-4057qib7 510 25 did do VBD cord-005453-4057qib7 510 26 C1 C1 NNP cord-005453-4057qib7 510 27 / / SYM cord-005453-4057qib7 510 28 C2 C2 NNP cord-005453-4057qib7 510 29 recipients recipient NNS cord-005453-4057qib7 510 30 after after IN cord-005453-4057qib7 510 31 HLA HLA NNP cord-005453-4057qib7 510 32 - - HYPH cord-005453-4057qib7 510 33 matched match VBN cord-005453-4057qib7 510 34 HSCT HSCT NNP cord-005453-4057qib7 510 35 for for IN cord-005453-4057qib7 510 36 acute acute JJ cord-005453-4057qib7 510 37 myeloid myeloid NN cord-005453-4057qib7 510 38 leukemia leukemia NN cord-005453-4057qib7 510 39 ( ( -LRB- cord-005453-4057qib7 510 40 AML AML NNP cord-005453-4057qib7 510 41 ; ; : cord-005453-4057qib7 511 1 HR hr NN cord-005453-4057qib7 511 2 = = SYM cord-005453-4057qib7 511 3 .79 .79 . cord-005453-4057qib7 512 1 , , , cord-005453-4057qib7 512 2 P p NN cord-005453-4057qib7 512 3 = = SYM cord-005453-4057qib7 512 4 .006 .006 CD cord-005453-4057qib7 512 5 ) ) -RRB- cord-005453-4057qib7 512 6 or or CC cord-005453-4057qib7 512 7 chronic chronic JJ cord-005453-4057qib7 512 8 myeloid myeloid NN cord-005453-4057qib7 512 9 leukemia leukemia NN cord-005453-4057qib7 512 10 ( ( -LRB- cord-005453-4057qib7 512 11 CML CML NNP cord-005453-4057qib7 512 12 ; ; : cord-005453-4057qib7 512 13 HR hr NN cord-005453-4057qib7 512 14 = = SYM cord-005453-4057qib7 512 15 .48 .48 . cord-005453-4057qib7 513 1 , , , cord-005453-4057qib7 513 2 P p NN cord-005453-4057qib7 513 3 = = SYM cord-005453-4057qib7 513 4 .025 .025 CD cord-005453-4057qib7 513 5 ) ) -RRB- cord-005453-4057qib7 513 6 . . . cord-005453-4057qib7 514 1 This this DT cord-005453-4057qib7 514 2 effect effect NN cord-005453-4057qib7 514 3 seemed seem VBD cord-005453-4057qib7 514 4 to to TO cord-005453-4057qib7 514 5 be be VB cord-005453-4057qib7 514 6 independent independent JJ cord-005453-4057qib7 514 7 of of IN cord-005453-4057qib7 514 8 acute acute JJ cord-005453-4057qib7 514 9 graft graft NN cord-005453-4057qib7 514 10 - - HYPH cord-005453-4057qib7 514 11 versus versus IN cord-005453-4057qib7 514 12 - - HYPH cord-005453-4057qib7 514 13 host host NN cord-005453-4057qib7 514 14 disease disease NN cord-005453-4057qib7 514 15 ( ( -LRB- cord-005453-4057qib7 514 16 aGVHD aGVHD NNP cord-005453-4057qib7 514 17 ) ) -RRB- cord-005453-4057qib7 514 18 or or CC cord-005453-4057qib7 514 19 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 514 20 reactivation reactivation NN cord-005453-4057qib7 514 21 occurrence occurrence NN cord-005453-4057qib7 514 22 ( ( -LRB- cord-005453-4057qib7 514 23 Arima Arima NNP cord-005453-4057qib7 514 24 N N NNP cord-005453-4057qib7 514 25 et et NNP cord-005453-4057qib7 514 26 al al NNP cord-005453-4057qib7 514 27 BBMT BBMT NNP cord-005453-4057qib7 514 28 2018 2018 CD cord-005453-4057qib7 514 29 ) ) -RRB- cord-005453-4057qib7 514 30 . . . cord-005453-4057qib7 515 1 Methods method NNS cord-005453-4057qib7 515 2 : : : cord-005453-4057qib7 516 1 Relapse relapse NN cord-005453-4057qib7 516 2 rates rate NNS cord-005453-4057qib7 516 3 of of IN cord-005453-4057qib7 516 4 Japanese japanese JJ cord-005453-4057qib7 516 5 recipients recipient NNS cord-005453-4057qib7 516 6 who who WP cord-005453-4057qib7 516 7 first first RB cord-005453-4057qib7 516 8 underwent undergo VBD cord-005453-4057qib7 516 9 HLA HLA NNP cord-005453-4057qib7 516 10 - - HYPH cord-005453-4057qib7 516 11 matched match VBN cord-005453-4057qib7 516 12 HSCT HSCT NNP cord-005453-4057qib7 516 13 between between IN cord-005453-4057qib7 516 14 1996 1996 CD cord-005453-4057qib7 516 15 and and CC cord-005453-4057qib7 516 16 2016 2016 CD cord-005453-4057qib7 516 17 for for IN cord-005453-4057qib7 516 18 the the DT cord-005453-4057qib7 516 19 treatment treatment NN cord-005453-4057qib7 516 20 of of IN cord-005453-4057qib7 516 21 acute acute JJ cord-005453-4057qib7 516 22 lymphoid lymphoid JJ cord-005453-4057qib7 516 23 leukemia leukemia NN cord-005453-4057qib7 516 24 ( ( -LRB- cord-005453-4057qib7 516 25 ALL all DT cord-005453-4057qib7 516 26 ) ) -RRB- cord-005453-4057qib7 516 27 were be VBD cord-005453-4057qib7 516 28 compared compare VBN cord-005453-4057qib7 516 29 between between IN cord-005453-4057qib7 516 30 C1 C1 NNP cord-005453-4057qib7 516 31 / / SYM cord-005453-4057qib7 516 32 C1 C1 NNP cord-005453-4057qib7 516 33 pairs pair NNS cord-005453-4057qib7 516 34 and and CC cord-005453-4057qib7 516 35 C1 C1 NNP cord-005453-4057qib7 516 36 / / SYM cord-005453-4057qib7 516 37 C2 C2 NNP cord-005453-4057qib7 516 38 pairs pair NNS cord-005453-4057qib7 516 39 , , , cord-005453-4057qib7 516 40 using use VBG cord-005453-4057qib7 516 41 data datum NNS cord-005453-4057qib7 516 42 from from IN cord-005453-4057qib7 516 43 Japanese Japanese NNP cord-005453-4057qib7 516 44 Data Data NNP cord-005453-4057qib7 516 45 Center Center NNP cord-005453-4057qib7 516 46 for for IN cord-005453-4057qib7 516 47 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 516 48 Cell Cell NNP cord-005453-4057qib7 516 49 Transplantation Transplantation NNP cord-005453-4057qib7 516 50 and and CC cord-005453-4057qib7 516 51 adjusting adjust VBG cord-005453-4057qib7 516 52 for for IN cord-005453-4057qib7 516 53 transplant transplant NN cord-005453-4057qib7 516 54 characteristics characteristic NNS cord-005453-4057qib7 516 55 . . . cord-005453-4057qib7 517 1 Cord cord NN cord-005453-4057qib7 517 2 blood blood NN cord-005453-4057qib7 517 3 transplantation transplantation NN cord-005453-4057qib7 517 4 was be VBD cord-005453-4057qib7 517 5 excluded exclude VBN cord-005453-4057qib7 517 6 . . . cord-005453-4057qib7 518 1 Multivariable multivariable JJ cord-005453-4057qib7 518 2 competing compete VBG cord-005453-4057qib7 518 3 risk risk NN cord-005453-4057qib7 518 4 regression regression NN cord-005453-4057qib7 518 5 analyses analysis NNS cord-005453-4057qib7 518 6 were be VBD cord-005453-4057qib7 518 7 performed perform VBN cord-005453-4057qib7 518 8 to to TO cord-005453-4057qib7 518 9 evaluate evaluate VB cord-005453-4057qib7 518 10 relapses relapse NNS cord-005453-4057qib7 518 11 and and CC cord-005453-4057qib7 518 12 relapse relapse NN cord-005453-4057qib7 518 13 - - HYPH cord-005453-4057qib7 518 14 free free JJ cord-005453-4057qib7 518 15 survival survival NN cord-005453-4057qib7 518 16 ( ( -LRB- cord-005453-4057qib7 518 17 RFS RFS NNP cord-005453-4057qib7 518 18 ) ) -RRB- cord-005453-4057qib7 518 19 was be VBD cord-005453-4057qib7 518 20 estimated estimate VBN cord-005453-4057qib7 518 21 using use VBG cord-005453-4057qib7 518 22 Kaplan Kaplan NNP cord-005453-4057qib7 518 23 - - HYPH cord-005453-4057qib7 518 24 Meier Meier NNP cord-005453-4057qib7 518 25 method method NN cord-005453-4057qib7 518 26 . . . cord-005453-4057qib7 519 1 Results result NNS cord-005453-4057qib7 519 2 : : : cord-005453-4057qib7 520 1 After after IN cord-005453-4057qib7 520 2 61 61 CD cord-005453-4057qib7 520 3 recipients recipient NNS cord-005453-4057qib7 520 4 who who WP cord-005453-4057qib7 520 5 did do VBD cord-005453-4057qib7 520 6 not not RB cord-005453-4057qib7 520 7 achieve achieve VB cord-005453-4057qib7 520 8 remission remission NN cord-005453-4057qib7 520 9 or or CC cord-005453-4057qib7 520 10 experienced experience VBN cord-005453-4057qib7 520 11 graft graft NN cord-005453-4057qib7 520 12 failure failure NN cord-005453-4057qib7 520 13 and and CC cord-005453-4057qib7 520 14 41 41 CD cord-005453-4057qib7 520 15 recipients recipient NNS cord-005453-4057qib7 520 16 not not RB cord-005453-4057qib7 520 17 - - HYPH cord-005453-4057qib7 520 18 expressing express VBG cord-005453-4057qib7 520 19 C1 C1 NNP cord-005453-4057qib7 520 20 were be VBD cord-005453-4057qib7 520 21 excluded exclude VBN cord-005453-4057qib7 520 22 , , , cord-005453-4057qib7 520 23 resting rest VBG cord-005453-4057qib7 520 24 2779 2779 CD cord-005453-4057qib7 520 25 recipients recipient NNS cord-005453-4057qib7 520 26 aged aged JJ cord-005453-4057qib7 520 27 0 0 CD cord-005453-4057qib7 520 28 - - SYM cord-005453-4057qib7 520 29 72 72 CD cord-005453-4057qib7 520 30 years year NNS cord-005453-4057qib7 520 31 ( ( -LRB- cord-005453-4057qib7 520 32 median median NN cord-005453-4057qib7 520 33 , , , cord-005453-4057qib7 520 34 31.2 31.2 CD cord-005453-4057qib7 520 35 years year NNS cord-005453-4057qib7 520 36 ) ) -RRB- cord-005453-4057qib7 520 37 were be VBD cord-005453-4057qib7 520 38 analyzed analyze VBN cord-005453-4057qib7 520 39 . . . cord-005453-4057qib7 521 1 The the DT cord-005453-4057qib7 521 2 median median JJ cord-005453-4057qib7 521 3 follow follow NN cord-005453-4057qib7 521 4 - - HYPH cord-005453-4057qib7 521 5 up up NN cord-005453-4057qib7 521 6 period period NN cord-005453-4057qib7 521 7 for for IN cord-005453-4057qib7 521 8 survivors survivor NNS cord-005453-4057qib7 521 9 was be VBD cord-005453-4057qib7 521 10 5.0 5.0 CD cord-005453-4057qib7 521 11 years year NNS cord-005453-4057qib7 521 12 . . . cord-005453-4057qib7 522 1 There there EX cord-005453-4057qib7 522 2 were be VBD cord-005453-4057qib7 522 3 2447 2447 CD cord-005453-4057qib7 522 4 recipients recipient NNS cord-005453-4057qib7 522 5 expressing express VBG cord-005453-4057qib7 522 6 C1 C1 NNP cord-005453-4057qib7 522 7 / / SYM cord-005453-4057qib7 522 8 C1 C1 NNP cord-005453-4057qib7 522 9 and and CC cord-005453-4057qib7 522 10 332 332 CD cord-005453-4057qib7 522 11 recipients recipient NNS cord-005453-4057qib7 522 12 expressing express VBG cord-005453-4057qib7 522 13 C1 C1 NNP cord-005453-4057qib7 522 14 / / SYM cord-005453-4057qib7 522 15 C2 C2 NNP cord-005453-4057qib7 522 16 , , , cord-005453-4057qib7 522 17 respectively respectively RB cord-005453-4057qib7 522 18 . . . cord-005453-4057qib7 523 1 After after IN cord-005453-4057qib7 523 2 HLA HLA NNP cord-005453-4057qib7 523 3 - - HYPH cord-005453-4057qib7 523 4 matched match VBN cord-005453-4057qib7 523 5 HSCT HSCT NNP cord-005453-4057qib7 523 6 , , , cord-005453-4057qib7 523 7 C1 C1 NNP cord-005453-4057qib7 523 8 / / SYM cord-005453-4057qib7 523 9 C1 C1 NNP cord-005453-4057qib7 523 10 recipients recipient NNS cord-005453-4057qib7 523 11 had have VBD cord-005453-4057qib7 523 12 higher high JJR cord-005453-4057qib7 523 13 relapse relapse NN cord-005453-4057qib7 523 14 rates rate NNS cord-005453-4057qib7 523 15 than than IN cord-005453-4057qib7 523 16 C1/ C1/ NNP cord-005453-4057qib7 523 17 C2 C2 NNP cord-005453-4057qib7 523 18 recipients recipient NNS cord-005453-4057qib7 523 19 ( ( -LRB- cord-005453-4057qib7 523 20 HR hr NN cord-005453-4057qib7 523 21 = = SYM cord-005453-4057qib7 523 22 1.55 1.55 CD cord-005453-4057qib7 523 23 , , , cord-005453-4057qib7 523 24 P p NN cord-005453-4057qib7 523 25 = = SYM cord-005453-4057qib7 523 26 .003 .003 CD cord-005453-4057qib7 523 27 ) ) -RRB- cord-005453-4057qib7 523 28 , , , cord-005453-4057qib7 523 29 resulting result VBG cord-005453-4057qib7 523 30 in in IN cord-005453-4057qib7 523 31 worse bad JJR cord-005453-4057qib7 523 32 RFS RFS NNP cord-005453-4057qib7 523 33 among among IN cord-005453-4057qib7 523 34 C1 C1 NNP cord-005453-4057qib7 523 35 / / SYM cord-005453-4057qib7 523 36 C1 C1 NNP cord-005453-4057qib7 523 37 recipients recipient NNS cord-005453-4057qib7 523 38 ( ( -LRB- cord-005453-4057qib7 523 39 HR hr NN cord-005453-4057qib7 523 40 = = SYM cord-005453-4057qib7 523 41 1.27 1.27 CD cord-005453-4057qib7 523 42 , , , cord-005453-4057qib7 523 43 P p NN cord-005453-4057qib7 523 44 = = SYM cord-005453-4057qib7 523 45 .034 .034 CD cord-005453-4057qib7 523 46 ) ) -RRB- cord-005453-4057qib7 523 47 . . . cord-005453-4057qib7 524 1 The the DT cord-005453-4057qib7 524 2 frequent frequent JJ cord-005453-4057qib7 524 3 relapse relapse NN cord-005453-4057qib7 524 4 in in IN cord-005453-4057qib7 524 5 C1 C1 NNP cord-005453-4057qib7 524 6 / / SYM cord-005453-4057qib7 524 7 C1 C1 NNP cord-005453-4057qib7 524 8 recipients recipient NNS cord-005453-4057qib7 524 9 than than IN cord-005453-4057qib7 524 10 in in IN cord-005453-4057qib7 524 11 C1 C1 NNP cord-005453-4057qib7 524 12 / / SYM cord-005453-4057qib7 524 13 C2 C2 NNP cord-005453-4057qib7 524 14 was be VBD cord-005453-4057qib7 524 15 noticeable noticeable JJ cord-005453-4057qib7 524 16 among among IN cord-005453-4057qib7 524 17 recipients recipient NNS cord-005453-4057qib7 524 18 with with IN cord-005453-4057qib7 524 19 aGVHD aGVHD NNP cord-005453-4057qib7 525 1 ( ( -LRB- cord-005453-4057qib7 525 2 HR hr NN cord-005453-4057qib7 525 3 = = SYM cord-005453-4057qib7 525 4 1.89 1.89 CD cord-005453-4057qib7 525 5 , , , cord-005453-4057qib7 525 6 P p NN cord-005453-4057qib7 525 7 = = SYM cord-005453-4057qib7 525 8 .002 .002 CD cord-005453-4057qib7 525 9 ) ) -RRB- cord-005453-4057qib7 525 10 , , , cord-005453-4057qib7 525 11 those those DT cord-005453-4057qib7 525 12 without without IN cord-005453-4057qib7 525 13 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 525 14 reactivation reactivation NN cord-005453-4057qib7 525 15 ( ( -LRB- cord-005453-4057qib7 525 16 HR hr NN cord-005453-4057qib7 525 17 = = SYM cord-005453-4057qib7 525 18 1.84 1.84 CD cord-005453-4057qib7 525 19 , , , cord-005453-4057qib7 525 20 P p NN cord-005453-4057qib7 525 21 = = SYM cord-005453-4057qib7 525 22 .002 .002 CD cord-005453-4057qib7 525 23 ) ) -RRB- cord-005453-4057qib7 525 24 , , , cord-005453-4057qib7 525 25 and and CC cord-005453-4057qib7 525 26 those those DT cord-005453-4057qib7 525 27 with with IN cord-005453-4057qib7 525 28 Ph Ph NNP cord-005453-4057qib7 525 29 - - JJ cord-005453-4057qib7 525 30 negative negative JJ cord-005453-4057qib7 525 31 ALL all DT cord-005453-4057qib7 525 32 ( ( -LRB- cord-005453-4057qib7 525 33 HR hr NN cord-005453-4057qib7 525 34 = = SYM cord-005453-4057qib7 525 35 1.88 1.88 CD cord-005453-4057qib7 525 36 , , , cord-005453-4057qib7 525 37 P p NN cord-005453-4057qib7 525 38 = = SYM cord-005453-4057qib7 525 39 .001 .001 CD cord-005453-4057qib7 525 40 ) ) -RRB- cord-005453-4057qib7 525 41 . . . cord-005453-4057qib7 526 1 Conclusions conclusion NNS cord-005453-4057qib7 526 2 : : : cord-005453-4057qib7 526 3 KIR2DL1-positive kir2dl1-positive JJ cord-005453-4057qib7 526 4 NK NK NNP cord-005453-4057qib7 526 5 cells cell NNS cord-005453-4057qib7 526 6 may may MD cord-005453-4057qib7 526 7 promote promote VB cord-005453-4057qib7 526 8 graft graft NN cord-005453-4057qib7 526 9 - - HYPH cord-005453-4057qib7 526 10 versus versus IN cord-005453-4057qib7 526 11 - - HYPH cord-005453-4057qib7 526 12 leukemia leukemia NN cord-005453-4057qib7 526 13 ( ( -LRB- cord-005453-4057qib7 526 14 GVL GVL NNP cord-005453-4057qib7 526 15 ) ) -RRB- cord-005453-4057qib7 526 16 in in IN cord-005453-4057qib7 526 17 C1 C1 NNP cord-005453-4057qib7 526 18 / / SYM cord-005453-4057qib7 526 19 C1 C1 NNP cord-005453-4057qib7 526 20 recipients recipient NNS cord-005453-4057qib7 526 21 with with IN cord-005453-4057qib7 526 22 AML AML NNP cord-005453-4057qib7 526 23 or or CC cord-005453-4057qib7 526 24 CML CML NNP cord-005453-4057qib7 526 25 but but CC cord-005453-4057qib7 526 26 suppress suppress VB cord-005453-4057qib7 526 27 GVL GVL NNP cord-005453-4057qib7 526 28 in in IN cord-005453-4057qib7 526 29 C1 C1 NNP cord-005453-4057qib7 526 30 / / SYM cord-005453-4057qib7 526 31 C1 C1 NNP cord-005453-4057qib7 526 32 recipients recipient NNS cord-005453-4057qib7 526 33 with with IN cord-005453-4057qib7 526 34 ALL all DT cord-005453-4057qib7 526 35 . . . cord-005453-4057qib7 527 1 One one CD cord-005453-4057qib7 527 2 interpretation interpretation NN cord-005453-4057qib7 527 3 is be VBZ cord-005453-4057qib7 527 4 that that IN cord-005453-4057qib7 527 5 transplant transplant NN cord-005453-4057qib7 527 6 - - HYPH cord-005453-4057qib7 527 7 activated activate VBN cord-005453-4057qib7 527 8 NK NK NNP cord-005453-4057qib7 527 9 cells cell NNS cord-005453-4057qib7 527 10 impair impair VBP cord-005453-4057qib7 527 11 antigen antigen NN cord-005453-4057qib7 527 12 - - HYPH cord-005453-4057qib7 527 13 presenting present VBG cord-005453-4057qib7 527 14 cells cell NNS cord-005453-4057qib7 527 15 or or CC cord-005453-4057qib7 527 16 deprive deprive VB cord-005453-4057qib7 527 17 cytotoxic cytotoxic JJ cord-005453-4057qib7 527 18 Tlymphocytes Tlymphocytes NNPS cord-005453-4057qib7 527 19 of of IN cord-005453-4057qib7 527 20 their -PRON- PRP$ cord-005453-4057qib7 527 21 GVL GVL NNP cord-005453-4057qib7 527 22 effects effect NNS cord-005453-4057qib7 527 23 on on IN cord-005453-4057qib7 527 24 ALL all DT cord-005453-4057qib7 527 25 cells cell NNS cord-005453-4057qib7 527 26 . . . cord-005453-4057qib7 528 1 This this DT cord-005453-4057qib7 528 2 hypothesis hypothesis NN cord-005453-4057qib7 528 3 may may MD cord-005453-4057qib7 528 4 be be VB cord-005453-4057qib7 528 5 explained explain VBN cord-005453-4057qib7 528 6 by by IN cord-005453-4057qib7 528 7 the the DT cord-005453-4057qib7 528 8 fact fact NN cord-005453-4057qib7 528 9 that that IN cord-005453-4057qib7 528 10 aGVHD aGVHD NNP cord-005453-4057qib7 528 11 was be VBD cord-005453-4057qib7 528 12 necessary necessary JJ cord-005453-4057qib7 528 13 for for IN cord-005453-4057qib7 528 14 the the DT cord-005453-4057qib7 528 15 recessive recessive JJ cord-005453-4057qib7 528 16 relapse relapse NN cord-005453-4057qib7 528 17 in in IN cord-005453-4057qib7 528 18 C1 C1 NNP cord-005453-4057qib7 528 19 / / SYM cord-005453-4057qib7 528 20 C1 C1 NNP cord-005453-4057qib7 528 21 recipients recipient NNS cord-005453-4057qib7 528 22 with with IN cord-005453-4057qib7 528 23 ALL all DT cord-005453-4057qib7 528 24 . . . cord-005453-4057qib7 529 1 Furthermore furthermore RB cord-005453-4057qib7 529 2 , , , cord-005453-4057qib7 529 3 Ph Ph NNP cord-005453-4057qib7 529 4 - - NN cord-005453-4057qib7 529 5 positive positive JJ cord-005453-4057qib7 529 6 ALL all DT cord-005453-4057qib7 529 7 cells cell NNS cord-005453-4057qib7 529 8 sometimes sometimes RB cord-005453-4057qib7 529 9 mimic mimic VBP cord-005453-4057qib7 529 10 AML AML NNP cord-005453-4057qib7 529 11 cells cell NNS cord-005453-4057qib7 529 12 in in IN cord-005453-4057qib7 529 13 terms term NNS cord-005453-4057qib7 529 14 of of IN cord-005453-4057qib7 529 15 their -PRON- PRP$ cord-005453-4057qib7 529 16 frequent frequent JJ cord-005453-4057qib7 529 17 myeloid myeloid JJ cord-005453-4057qib7 529 18 antigen antigen NN cord-005453-4057qib7 529 19 expression expression NN cord-005453-4057qib7 529 20 and and CC cord-005453-4057qib7 529 21 might may MD cord-005453-4057qib7 529 22 be be VB cord-005453-4057qib7 529 23 directly directly RB cord-005453-4057qib7 529 24 targeted target VBN cord-005453-4057qib7 529 25 by by IN cord-005453-4057qib7 529 26 NK NK NNP cord-005453-4057qib7 529 27 cells cell NNS cord-005453-4057qib7 529 28 . . . cord-005453-4057qib7 530 1 It -PRON- PRP cord-005453-4057qib7 530 2 would would MD cord-005453-4057qib7 530 3 be be VB cord-005453-4057qib7 530 4 necessary necessary JJ cord-005453-4057qib7 530 5 to to TO cord-005453-4057qib7 530 6 further further RB cord-005453-4057qib7 530 7 clarify clarify VB cord-005453-4057qib7 530 8 in in IN cord-005453-4057qib7 530 9 vitro vitro FW cord-005453-4057qib7 530 10 the the DT cord-005453-4057qib7 530 11 character character NN cord-005453-4057qib7 530 12 of of IN cord-005453-4057qib7 530 13 NK NK NNP cord-005453-4057qib7 530 14 cell cell NN cord-005453-4057qib7 530 15 - - HYPH cord-005453-4057qib7 530 16 affecting affect VBG cord-005453-4057qib7 530 17 in in IN cord-005453-4057qib7 530 18 the the DT cord-005453-4057qib7 530 19 transplant transplant NN cord-005453-4057qib7 530 20 immunity immunity NN cord-005453-4057qib7 530 21 against against IN cord-005453-4057qib7 530 22 residual residual JJ cord-005453-4057qib7 530 23 leukemia leukemia NN cord-005453-4057qib7 530 24 cells cell NNS cord-005453-4057qib7 530 25 . . . cord-005453-4057qib7 531 1 Disclosure disclosure NN cord-005453-4057qib7 531 2 : : : cord-005453-4057qib7 532 1 Authors author NNS cord-005453-4057qib7 532 2 have have VBP cord-005453-4057qib7 532 3 nothing nothing NN cord-005453-4057qib7 532 4 to to TO cord-005453-4057qib7 532 5 declare declare VB cord-005453-4057qib7 532 6 . . . cord-005453-4057qib7 533 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 533 2 stem stem NN cord-005453-4057qib7 533 3 cell cell NN cord-005453-4057qib7 533 4 transplantation transplantation NN cord-005453-4057qib7 533 5 with with IN cord-005453-4057qib7 533 6 sequential sequential JJ cord-005453-4057qib7 533 7 conditioning conditioning NN cord-005453-4057qib7 533 8 for for IN cord-005453-4057qib7 533 9 children child NNS cord-005453-4057qib7 533 10 with with IN cord-005453-4057qib7 533 11 relapsed relapse VBN cord-005453-4057qib7 533 12 / / SYM cord-005453-4057qib7 533 13 refractory refractory JJ cord-005453-4057qib7 533 14 acute acute JJ cord-005453-4057qib7 533 15 leukemia leukemia NN cord-005453-4057qib7 534 1 Nao Nao NNP cord-005453-4057qib7 534 2 Yoshida Yoshida NNP cord-005453-4057qib7 534 3 1 1 CD cord-005453-4057qib7 534 4 , , , cord-005453-4057qib7 534 5 Kazuki Kazuki NNP cord-005453-4057qib7 534 6 Matsumoto Matsumoto NNP cord-005453-4057qib7 534 7 1 1 CD cord-005453-4057qib7 534 8 , , , cord-005453-4057qib7 534 9 Daiki Daiki NNP cord-005453-4057qib7 534 10 Yamashita Yamashita NNP cord-005453-4057qib7 534 11 1 1 CD cord-005453-4057qib7 534 12 , , , cord-005453-4057qib7 534 13 Yiqing Yiqing NNP cord-005453-4057qib7 534 14 Zhu Zhu NNP cord-005453-4057qib7 534 15 1 1 CD cord-005453-4057qib7 534 16 , , , cord-005453-4057qib7 534 17 Daichi Daichi NNP cord-005453-4057qib7 534 18 Sajiki Sajiki NNP cord-005453-4057qib7 534 19 1 1 CD cord-005453-4057qib7 534 20 , , , cord-005453-4057qib7 534 21 Ryo Ryo NNP cord-005453-4057qib7 534 22 Maemura Maemura NNP cord-005453-4057qib7 534 23 1 1 CD cord-005453-4057qib7 534 24 , , , cord-005453-4057qib7 534 25 Hirotoshi Hirotoshi NNP cord-005453-4057qib7 534 26 Sakaguchi Sakaguchi NNP cord-005453-4057qib7 534 27 1 1 CD cord-005453-4057qib7 535 1 , , , cord-005453-4057qib7 535 2 Asahito Asahito NNP cord-005453-4057qib7 535 3 Hama Hama NNP cord-005453-4057qib7 535 4 1 1 CD cord-005453-4057qib7 535 5 1 1 CD cord-005453-4057qib7 535 6 Children Children NNPS cord-005453-4057qib7 535 7 's 's POS cord-005453-4057qib7 535 8 Medical Medical NNP cord-005453-4057qib7 535 9 Center Center NNP cord-005453-4057qib7 535 10 , , , cord-005453-4057qib7 535 11 Japanese Japanese NNP cord-005453-4057qib7 535 12 Red Red NNP cord-005453-4057qib7 535 13 Cross Cross NNP cord-005453-4057qib7 535 14 Nagoya Nagoya NNP cord-005453-4057qib7 535 15 First First NNP cord-005453-4057qib7 535 16 Hospital Hospital NNP cord-005453-4057qib7 535 17 , , , cord-005453-4057qib7 535 18 Nagoya Nagoya NNP cord-005453-4057qib7 535 19 , , , cord-005453-4057qib7 536 1 Japan Japan NNP cord-005453-4057qib7 536 2 Background Background NNP cord-005453-4057qib7 536 3 : : : cord-005453-4057qib7 537 1 Patients patient NNS cord-005453-4057qib7 537 2 with with IN cord-005453-4057qib7 537 3 acute acute JJ cord-005453-4057qib7 537 4 leukemia leukemia NN cord-005453-4057qib7 537 5 who who WP cord-005453-4057qib7 537 6 fail fail VBP cord-005453-4057qib7 537 7 to to TO cord-005453-4057qib7 537 8 achieve achieve VB cord-005453-4057qib7 537 9 complete complete JJ cord-005453-4057qib7 537 10 remission remission NN cord-005453-4057qib7 537 11 show show VBP cord-005453-4057qib7 537 12 a a DT cord-005453-4057qib7 537 13 dismal dismal JJ cord-005453-4057qib7 537 14 prognosis prognosis NN cord-005453-4057qib7 537 15 even even RB cord-005453-4057qib7 537 16 with with IN cord-005453-4057qib7 537 17 allogeneic allogeneic JJ cord-005453-4057qib7 537 18 hematopoietic hematopoietic JJ cord-005453-4057qib7 537 19 stem stem NN cord-005453-4057qib7 537 20 cell cell NN cord-005453-4057qib7 537 21 transplantation transplantation NN cord-005453-4057qib7 537 22 ( ( -LRB- cord-005453-4057qib7 537 23 HSCT HSCT NNP cord-005453-4057qib7 537 24 ) ) -RRB- cord-005453-4057qib7 537 25 . . . cord-005453-4057qib7 538 1 This this DT cord-005453-4057qib7 538 2 study study NN cord-005453-4057qib7 538 3 evaluated evaluate VBD cord-005453-4057qib7 538 4 whether whether IN cord-005453-4057qib7 538 5 sequential sequential JJ cord-005453-4057qib7 538 6 conditioning conditioning NN cord-005453-4057qib7 538 7 approach approach NN cord-005453-4057qib7 538 8 that that WDT cord-005453-4057qib7 538 9 is be VBZ cord-005453-4057qib7 538 10 cytoreductive cytoreductive JJ cord-005453-4057qib7 538 11 chemotherapy chemotherapy NN cord-005453-4057qib7 538 12 applied apply VBN cord-005453-4057qib7 538 13 shortly shortly RB cord-005453-4057qib7 538 14 prior prior RB cord-005453-4057qib7 538 15 to to IN cord-005453-4057qib7 538 16 the the DT cord-005453-4057qib7 538 17 main main JJ cord-005453-4057qib7 538 18 conditioning conditioning NN cord-005453-4057qib7 538 19 followed follow VBN cord-005453-4057qib7 538 20 by by IN cord-005453-4057qib7 538 21 HSCT HSCT NNP cord-005453-4057qib7 538 22 can can MD cord-005453-4057qib7 538 23 improve improve VB cord-005453-4057qib7 538 24 prognosis prognosis NN cord-005453-4057qib7 538 25 in in IN cord-005453-4057qib7 538 26 such such JJ cord-005453-4057qib7 538 27 high high JJ cord-005453-4057qib7 538 28 - - HYPH cord-005453-4057qib7 538 29 risk risk NN cord-005453-4057qib7 538 30 patients patient NNS cord-005453-4057qib7 538 31 . . . cord-005453-4057qib7 539 1 Methods method NNS cord-005453-4057qib7 539 2 : : : cord-005453-4057qib7 539 3 We -PRON- PRP cord-005453-4057qib7 539 4 retrospectively retrospectively RB cord-005453-4057qib7 539 5 analyzed analyze VBD cord-005453-4057qib7 539 6 the the DT cord-005453-4057qib7 539 7 outcomes outcome NNS cord-005453-4057qib7 539 8 of of IN cord-005453-4057qib7 539 9 90 90 CD cord-005453-4057qib7 539 10 children child NNS cord-005453-4057qib7 539 11 ( ( -LRB- cord-005453-4057qib7 539 12 median median JJ cord-005453-4057qib7 539 13 8 8 CD cord-005453-4057qib7 539 14 , , , cord-005453-4057qib7 539 15 range range VBP cord-005453-4057qib7 539 16 0 0 CD cord-005453-4057qib7 539 17 - - SYM cord-005453-4057qib7 539 18 18 18 CD cord-005453-4057qib7 539 19 years year NNS cord-005453-4057qib7 539 20 old old JJ cord-005453-4057qib7 539 21 ) ) -RRB- cord-005453-4057qib7 539 22 with with IN cord-005453-4057qib7 539 23 primary primary JJ cord-005453-4057qib7 539 24 refractory refractory NN cord-005453-4057qib7 539 25 ( ( -LRB- cord-005453-4057qib7 539 26 n n NN cord-005453-4057qib7 539 27 = = SYM cord-005453-4057qib7 539 28 11 11 CD cord-005453-4057qib7 539 29 ) ) -RRB- cord-005453-4057qib7 539 30 or or CC cord-005453-4057qib7 539 31 refractory refractory JJ cord-005453-4057qib7 539 32 relapsed relapse VBD cord-005453-4057qib7 539 33 ( ( -LRB- cord-005453-4057qib7 539 34 n n NN cord-005453-4057qib7 539 35 = = SYM cord-005453-4057qib7 539 36 79 79 CD cord-005453-4057qib7 539 37 ) ) -RRB- cord-005453-4057qib7 539 38 acute acute JJ cord-005453-4057qib7 539 39 leukemia leukemia NN cord-005453-4057qib7 539 40 ( ( -LRB- cord-005453-4057qib7 539 41 AML AML NNP cord-005453-4057qib7 539 42 n n CC cord-005453-4057qib7 539 43 = = SYM cord-005453-4057qib7 539 44 43 43 CD cord-005453-4057qib7 539 45 , , , cord-005453-4057qib7 539 46 ALL all DT cord-005453-4057qib7 539 47 n n NN cord-005453-4057qib7 539 48 = = SYM cord-005453-4057qib7 539 49 47 47 CD cord-005453-4057qib7 539 50 ) ) -RRB- cord-005453-4057qib7 539 51 who who WP cord-005453-4057qib7 539 52 received receive VBD cord-005453-4057qib7 539 53 HSCT HSCT NNP cord-005453-4057qib7 539 54 in in IN cord-005453-4057qib7 539 55 our -PRON- PRP$ cord-005453-4057qib7 539 56 department department NN cord-005453-4057qib7 539 57 between between IN cord-005453-4057qib7 539 58 1990 1990 CD cord-005453-4057qib7 539 59 and and CC cord-005453-4057qib7 539 60 2016 2016 CD cord-005453-4057qib7 539 61 . . . cord-005453-4057qib7 540 1 The the DT cord-005453-4057qib7 540 2 stem stem NN cord-005453-4057qib7 540 3 cell cell NN cord-005453-4057qib7 540 4 source source NN cord-005453-4057qib7 540 5 was be VBD cord-005453-4057qib7 540 6 related relate VBN cord-005453-4057qib7 540 7 peripheral peripheral JJ cord-005453-4057qib7 540 8 blood blood NN cord-005453-4057qib7 540 9 ( ( -LRB- cord-005453-4057qib7 540 10 PB PB NNP cord-005453-4057qib7 540 11 ) ) -RRB- cord-005453-4057qib7 540 12 in in IN cord-005453-4057qib7 540 13 4 4 CD cord-005453-4057qib7 540 14 patients patient NNS cord-005453-4057qib7 540 15 , , , cord-005453-4057qib7 540 16 related related JJ cord-005453-4057qib7 540 17 bone bone NN cord-005453-4057qib7 540 18 marrow marrow NN cord-005453-4057qib7 540 19 in in IN cord-005453-4057qib7 540 20 31 31 CD cord-005453-4057qib7 540 21 , , , cord-005453-4057qib7 540 22 unrelated unrelated JJ cord-005453-4057qib7 540 23 bone bone NN cord-005453-4057qib7 540 24 marrow marrow NN cord-005453-4057qib7 540 25 in in IN cord-005453-4057qib7 540 26 40 40 CD cord-005453-4057qib7 540 27 , , , cord-005453-4057qib7 540 28 or or CC cord-005453-4057qib7 540 29 unrelated unrelated JJ cord-005453-4057qib7 540 30 cord cord NN cord-005453-4057qib7 540 31 blood blood NN cord-005453-4057qib7 540 32 in in IN cord-005453-4057qib7 540 33 15 15 CD cord-005453-4057qib7 540 34 . . . cord-005453-4057qib7 541 1 The the DT cord-005453-4057qib7 541 2 grafts graft NNS cord-005453-4057qib7 541 3 were be VBD cord-005453-4057qib7 541 4 HLA HLA NNP cord-005453-4057qib7 541 5 serologically serologically RB cord-005453-4057qib7 541 6 matched match VBN cord-005453-4057qib7 541 7 ( ( -LRB- cord-005453-4057qib7 541 8 n n NN cord-005453-4057qib7 541 9 = = SYM cord-005453-4057qib7 541 10 63 63 CD cord-005453-4057qib7 541 11 ) ) -RRB- cord-005453-4057qib7 541 12 or or CC cord-005453-4057qib7 541 13 mismatched mismatch VBN cord-005453-4057qib7 541 14 ( ( -LRB- cord-005453-4057qib7 541 15 n n NN cord-005453-4057qib7 541 16 = = SYM cord-005453-4057qib7 541 17 27 27 CD cord-005453-4057qib7 541 18 ) ) -RRB- cord-005453-4057qib7 541 19 with with IN cord-005453-4057qib7 541 20 the the DT cord-005453-4057qib7 541 21 recipient recipient NN cord-005453-4057qib7 541 22 . . . cord-005453-4057qib7 542 1 In in IN cord-005453-4057qib7 542 2 total total NN cord-005453-4057qib7 542 3 , , , cord-005453-4057qib7 542 4 29 29 CD cord-005453-4057qib7 542 5 patients patient NNS cord-005453-4057qib7 542 6 received receive VBD cord-005453-4057qib7 542 7 the the DT cord-005453-4057qib7 542 8 sequential sequential JJ cord-005453-4057qib7 542 9 conditioning conditioning NN cord-005453-4057qib7 542 10 approach approach NN cord-005453-4057qib7 542 11 . . . cord-005453-4057qib7 543 1 As as IN cord-005453-4057qib7 543 2 cytoreductive cytoreductive JJ cord-005453-4057qib7 543 3 chemotherapy chemotherapy NN cord-005453-4057qib7 543 4 , , , cord-005453-4057qib7 543 5 fludarabine fludarabine NN cord-005453-4057qib7 543 6 / / SYM cord-005453-4057qib7 543 7 cytarabine cytarabine NNP cord-005453-4057qib7 543 8 / / SYM cord-005453-4057qib7 543 9 idarubicin idarubicin NNS cord-005453-4057qib7 543 10 / / SYM cord-005453-4057qib7 543 11 G G NNP cord-005453-4057qib7 543 12 - - HYPH cord-005453-4057qib7 543 13 CSF CSF NNP cord-005453-4057qib7 543 14 ( ( -LRB- cord-005453-4057qib7 543 15 FLAG FLAG NNP cord-005453-4057qib7 543 16 - - HYPH cord-005453-4057qib7 543 17 IDA IDA NNP cord-005453-4057qib7 543 18 ) ) -RRB- cord-005453-4057qib7 543 19 was be VBD cord-005453-4057qib7 543 20 used use VBN cord-005453-4057qib7 543 21 in in IN cord-005453-4057qib7 543 22 12 12 CD cord-005453-4057qib7 543 23 patients patient NNS cord-005453-4057qib7 543 24 , , , cord-005453-4057qib7 543 25 mitoxantrone mitoxantrone NN cord-005453-4057qib7 543 26 or or CC cord-005453-4057qib7 543 27 daunorubicin daunorubicin NNS cord-005453-4057qib7 543 28 / / SYM cord-005453-4057qib7 543 29 cytarabin cytarabin NN cord-005453-4057qib7 543 30 in in IN cord-005453-4057qib7 543 31 10 10 CD cord-005453-4057qib7 543 32 , , , cord-005453-4057qib7 543 33 or or CC cord-005453-4057qib7 543 34 other other JJ cord-005453-4057qib7 543 35 regimens regimen NNS cord-005453-4057qib7 543 36 in in IN cord-005453-4057qib7 543 37 7 7 CD cord-005453-4057qib7 543 38 , , , cord-005453-4057qib7 543 39 and and CC cord-005453-4057qib7 543 40 6 6 CD cord-005453-4057qib7 543 41 of of IN cord-005453-4057qib7 543 42 them -PRON- PRP cord-005453-4057qib7 543 43 were be VBD cord-005453-4057qib7 543 44 combined combine VBN cord-005453-4057qib7 543 45 with with IN cord-005453-4057qib7 543 46 gemtuzumab gemtuzumab JJ cord-005453-4057qib7 543 47 ozogamicin ozogamicin NNS cord-005453-4057qib7 543 48 . . . cord-005453-4057qib7 544 1 Without without IN cord-005453-4057qib7 544 2 waiting wait VBG cord-005453-4057qib7 544 3 for for IN cord-005453-4057qib7 544 4 hematological hematological JJ cord-005453-4057qib7 544 5 recovery recovery NN cord-005453-4057qib7 544 6 , , , cord-005453-4057qib7 544 7 the the DT cord-005453-4057qib7 544 8 patients patient NNS cord-005453-4057qib7 544 9 promptly promptly RB cord-005453-4057qib7 544 10 underwent undergo VBD cord-005453-4057qib7 544 11 HSCT HSCT NNP cord-005453-4057qib7 544 12 ; ; : cord-005453-4057qib7 544 13 therefore therefore RB cord-005453-4057qib7 544 14 , , , cord-005453-4057qib7 544 15 the the DT cord-005453-4057qib7 544 16 median median JJ cord-005453-4057qib7 544 17 interval interval NN cord-005453-4057qib7 544 18 between between IN cord-005453-4057qib7 544 19 cytoreductive cytoreductive JJ cord-005453-4057qib7 544 20 chemotherapy chemotherapy NN cord-005453-4057qib7 544 21 and and CC cord-005453-4057qib7 544 22 main main JJ cord-005453-4057qib7 544 23 conditioning conditioning NN cord-005453-4057qib7 544 24 was be VBD cord-005453-4057qib7 544 25 11 11 CD cord-005453-4057qib7 544 26 days day NNS cord-005453-4057qib7 544 27 . . . cord-005453-4057qib7 545 1 The the DT cord-005453-4057qib7 545 2 main main JJ cord-005453-4057qib7 545 3 conditioning conditioning NN cord-005453-4057qib7 545 4 regimens regimen NNS cord-005453-4057qib7 545 5 were be VBD cord-005453-4057qib7 545 6 total total JJ cord-005453-4057qib7 545 7 body body NN cord-005453-4057qib7 545 8 irradiation irradiation NN cord-005453-4057qib7 545 9 - - HYPH cord-005453-4057qib7 545 10 based base VBN cord-005453-4057qib7 545 11 myeloablative myeloablative NNP cord-005453-4057qib7 545 12 ( ( -LRB- cord-005453-4057qib7 545 13 n n NN cord-005453-4057qib7 545 14 = = SYM cord-005453-4057qib7 545 15 22 22 CD cord-005453-4057qib7 545 16 ) ) -RRB- cord-005453-4057qib7 545 17 , , , cord-005453-4057qib7 545 18 busulfan busulfan NN cord-005453-4057qib7 545 19 - - HYPH cord-005453-4057qib7 545 20 based base VBN cord-005453-4057qib7 545 21 myeloablative myeloablative NNP cord-005453-4057qib7 545 22 ( ( -LRB- cord-005453-4057qib7 545 23 n n NN cord-005453-4057qib7 545 24 = = SYM cord-005453-4057qib7 545 25 4 4 CD cord-005453-4057qib7 545 26 ) ) -RRB- cord-005453-4057qib7 545 27 , , , cord-005453-4057qib7 545 28 or or CC cord-005453-4057qib7 545 29 reduced reduce VBN cord-005453-4057qib7 545 30 intensity intensity NN cord-005453-4057qib7 545 31 ( ( -LRB- cord-005453-4057qib7 545 32 n n NN cord-005453-4057qib7 545 33 = = SYM cord-005453-4057qib7 545 34 3 3 CD cord-005453-4057qib7 545 35 ) ) -RRB- cord-005453-4057qib7 545 36 . . . cord-005453-4057qib7 546 1 Results result NNS cord-005453-4057qib7 546 2 : : : cord-005453-4057qib7 547 1 In in IN cord-005453-4057qib7 547 2 90 90 CD cord-005453-4057qib7 547 3 children child NNS cord-005453-4057qib7 547 4 with with IN cord-005453-4057qib7 547 5 relapsed relapse VBN cord-005453-4057qib7 547 6 / / SYM cord-005453-4057qib7 547 7 refractory refractory JJ cord-005453-4057qib7 547 8 acute acute JJ cord-005453-4057qib7 547 9 leukemia leukemia NN cord-005453-4057qib7 547 10 , , , cord-005453-4057qib7 547 11 the the DT cord-005453-4057qib7 547 12 5-year 5-year CD cord-005453-4057qib7 547 13 overall overall JJ cord-005453-4057qib7 547 14 survival survival NN cord-005453-4057qib7 547 15 ( ( -LRB- cord-005453-4057qib7 547 16 OS OS NNP cord-005453-4057qib7 547 17 ) ) -RRB- cord-005453-4057qib7 547 18 , , , cord-005453-4057qib7 547 19 leukemia leukemia NN cord-005453-4057qib7 547 20 - - HYPH cord-005453-4057qib7 547 21 free free JJ cord-005453-4057qib7 547 22 survival survival NN cord-005453-4057qib7 547 23 ( ( -LRB- cord-005453-4057qib7 547 24 LFS LFS NNP cord-005453-4057qib7 547 25 ) ) -RRB- cord-005453-4057qib7 547 26 , , , cord-005453-4057qib7 547 27 cumulative cumulative JJ cord-005453-4057qib7 547 28 incidence incidence NN cord-005453-4057qib7 547 29 of of IN cord-005453-4057qib7 547 30 relapse relapse NN cord-005453-4057qib7 547 31 ( ( -LRB- cord-005453-4057qib7 547 32 RI RI NNP cord-005453-4057qib7 547 33 ) ) -RRB- cord-005453-4057qib7 547 34 , , , cord-005453-4057qib7 547 35 and and CC cord-005453-4057qib7 547 36 transplantation transplantation NN cord-005453-4057qib7 547 37 - - HYPH cord-005453-4057qib7 547 38 related relate VBN cord-005453-4057qib7 547 39 mortality mortality NN cord-005453-4057qib7 547 40 ( ( -LRB- cord-005453-4057qib7 547 41 TRM TRM NNP cord-005453-4057qib7 547 42 ) ) -RRB- cord-005453-4057qib7 547 43 were be VBD cord-005453-4057qib7 547 44 24 24 CD cord-005453-4057qib7 547 45 % % NN cord-005453-4057qib7 547 46 , , , cord-005453-4057qib7 547 47 21 21 CD cord-005453-4057qib7 547 48 % % NN cord-005453-4057qib7 547 49 , , , cord-005453-4057qib7 547 50 53 53 CD cord-005453-4057qib7 547 51 % % NN cord-005453-4057qib7 547 52 , , , cord-005453-4057qib7 547 53 and and CC cord-005453-4057qib7 547 54 26 26 CD cord-005453-4057qib7 547 55 % % NN cord-005453-4057qib7 547 56 , , , cord-005453-4057qib7 547 57 respectively respectively RB cord-005453-4057qib7 547 58 . . . cord-005453-4057qib7 548 1 In in IN cord-005453-4057qib7 548 2 multivariate multivariate JJ cord-005453-4057qib7 548 3 analysis analysis NN cord-005453-4057qib7 548 4 , , , cord-005453-4057qib7 548 5 the the DT cord-005453-4057qib7 548 6 use use NN cord-005453-4057qib7 548 7 of of IN cord-005453-4057qib7 548 8 sequential sequential JJ cord-005453-4057qib7 548 9 conditioning conditioning NN cord-005453-4057qib7 548 10 was be VBD cord-005453-4057qib7 548 11 identified identify VBN cord-005453-4057qib7 548 12 as as IN cord-005453-4057qib7 548 13 the the DT cord-005453-4057qib7 548 14 most most RBS cord-005453-4057qib7 548 15 favorable favorable JJ cord-005453-4057qib7 548 16 factor factor NN cord-005453-4057qib7 548 17 for for IN cord-005453-4057qib7 548 18 LFS LFS NNP cord-005453-4057qib7 548 19 ( ( -LRB- cord-005453-4057qib7 548 20 hazard hazard NN cord-005453-4057qib7 548 21 ratio ratio NN cord-005453-4057qib7 548 22 [ [ -LRB- cord-005453-4057qib7 548 23 HR HR NNP cord-005453-4057qib7 548 24 ] ] -RRB- cord-005453-4057qib7 548 25 0.37 0.37 CD cord-005453-4057qib7 548 26 ; ; : cord-005453-4057qib7 549 1 P p NN cord-005453-4057qib7 549 2 = = SYM cord-005453-4057qib7 549 3 0.001 0.001 CD cord-005453-4057qib7 549 4 ) ) -RRB- cord-005453-4057qib7 549 5 , , , cord-005453-4057qib7 549 6 although although IN cord-005453-4057qib7 549 7 there there EX cord-005453-4057qib7 549 8 were be VBD cord-005453-4057qib7 549 9 no no DT cord-005453-4057qib7 549 10 differences difference NNS cord-005453-4057qib7 549 11 in in IN cord-005453-4057qib7 549 12 the the DT cord-005453-4057qib7 549 13 outcomes outcome NNS cord-005453-4057qib7 549 14 according accord VBG cord-005453-4057qib7 549 15 to to IN cord-005453-4057qib7 549 16 the the DT cord-005453-4057qib7 549 17 types type NNS cord-005453-4057qib7 549 18 of of IN cord-005453-4057qib7 549 19 cytoreductive cytoreductive JJ cord-005453-4057qib7 549 20 chemotherapy chemotherapy NN cord-005453-4057qib7 549 21 or or CC cord-005453-4057qib7 549 22 the the DT cord-005453-4057qib7 549 23 main main JJ cord-005453-4057qib7 549 24 conditioning conditioning NN cord-005453-4057qib7 549 25 regimen regimen NN cord-005453-4057qib7 549 26 . . . cord-005453-4057qib7 550 1 HLA HLA NNP cord-005453-4057qib7 550 2 - - HYPH cord-005453-4057qib7 550 3 matched match VBN cord-005453-4057qib7 550 4 donor donor NN cord-005453-4057qib7 550 5 ( ( -LRB- cord-005453-4057qib7 550 6 HR hr NN cord-005453-4057qib7 550 7 0.46 0.46 CD cord-005453-4057qib7 550 8 ; ; : cord-005453-4057qib7 550 9 P p NN cord-005453-4057qib7 550 10 = = SYM cord-005453-4057qib7 550 11 0.005 0.005 CD cord-005453-4057qib7 550 12 ) ) -RRB- cord-005453-4057qib7 550 13 and and CC cord-005453-4057qib7 550 14 PB PB NNP cord-005453-4057qib7 550 15 blasts blast NNS cord-005453-4057qib7 550 16 - - HYPH cord-005453-4057qib7 550 17 negative negative JJ cord-005453-4057qib7 550 18 at at IN cord-005453-4057qib7 550 19 the the DT cord-005453-4057qib7 550 20 beginning beginning NN cord-005453-4057qib7 550 21 of of IN cord-005453-4057qib7 550 22 conditioning conditioning NN cord-005453-4057qib7 550 23 ( ( -LRB- cord-005453-4057qib7 550 24 HR HR NNP cord-005453-4057qib7 550 25 0.49 0.49 CD cord-005453-4057qib7 550 26 ; ; : cord-005453-4057qib7 550 27 P p NN cord-005453-4057qib7 550 28 = = SYM cord-005453-4057qib7 550 29 0.02 0.02 CD cord-005453-4057qib7 550 30 ) ) -RRB- cord-005453-4057qib7 550 31 were be VBD cord-005453-4057qib7 550 32 also also RB cord-005453-4057qib7 550 33 independently independently RB cord-005453-4057qib7 550 34 associated associate VBN cord-005453-4057qib7 550 35 with with IN cord-005453-4057qib7 550 36 better well JJR cord-005453-4057qib7 550 37 LFS lfs NN cord-005453-4057qib7 550 38 . . . cord-005453-4057qib7 551 1 With with IN cord-005453-4057qib7 551 2 sequential sequential JJ cord-005453-4057qib7 551 3 conditioning conditioning NN cord-005453-4057qib7 551 4 , , , cord-005453-4057qib7 551 5 leukemia leukemia NN cord-005453-4057qib7 551 6 burden burden NN cord-005453-4057qib7 551 7 prior prior RB cord-005453-4057qib7 551 8 to to IN cord-005453-4057qib7 551 9 the the DT cord-005453-4057qib7 551 10 HSCT HSCT NNP cord-005453-4057qib7 551 11 was be VBD cord-005453-4057qib7 551 12 significantly significantly RB cord-005453-4057qib7 551 13 reduced reduce VBN cord-005453-4057qib7 551 14 ; ; : cord-005453-4057qib7 551 15 PB PB NNP cord-005453-4057qib7 551 16 blasts blast NNS cord-005453-4057qib7 551 17 became become VBD cord-005453-4057qib7 551 18 undetectable undetectable JJ cord-005453-4057qib7 551 19 at at IN cord-005453-4057qib7 551 20 the the DT cord-005453-4057qib7 551 21 beginning beginning NN cord-005453-4057qib7 551 22 of of IN cord-005453-4057qib7 551 23 conditioning conditioning NN cord-005453-4057qib7 551 24 in in IN cord-005453-4057qib7 551 25 66 66 CD cord-005453-4057qib7 551 26 % % NN cord-005453-4057qib7 551 27 patients patient NNS cord-005453-4057qib7 551 28 given give VBN cord-005453-4057qib7 551 29 the the DT cord-005453-4057qib7 551 30 approach approach NN cord-005453-4057qib7 551 31 , , , cord-005453-4057qib7 551 32 while while IN cord-005453-4057qib7 551 33 in in IN cord-005453-4057qib7 551 34 38 38 CD cord-005453-4057qib7 551 35 % % NN cord-005453-4057qib7 551 36 patients patient NNS cord-005453-4057qib7 551 37 without without IN cord-005453-4057qib7 551 38 the the DT cord-005453-4057qib7 551 39 approach approach NN cord-005453-4057qib7 551 40 ( ( -LRB- cord-005453-4057qib7 551 41 P p NN cord-005453-4057qib7 551 42 = = SYM cord-005453-4057qib7 551 43 0.02 0.02 CD cord-005453-4057qib7 551 44 ) ) -RRB- cord-005453-4057qib7 551 45 . . . cord-005453-4057qib7 552 1 Notably notably RB cord-005453-4057qib7 552 2 , , , cord-005453-4057qib7 552 3 the the DT cord-005453-4057qib7 552 4 outcomes outcome NNS cord-005453-4057qib7 552 5 in in IN cord-005453-4057qib7 552 6 the the DT cord-005453-4057qib7 552 7 patients patient NNS cord-005453-4057qib7 552 8 without without IN cord-005453-4057qib7 552 9 PB PB NNP cord-005453-4057qib7 552 10 blasts blast NNS cord-005453-4057qib7 552 11 at at IN cord-005453-4057qib7 552 12 the the DT cord-005453-4057qib7 552 13 beginning beginning NN cord-005453-4057qib7 552 14 of of IN cord-005453-4057qib7 552 15 conditioning conditioning NN cord-005453-4057qib7 552 16 who who WP cord-005453-4057qib7 552 17 received receive VBD cord-005453-4057qib7 552 18 sequential sequential JJ cord-005453-4057qib7 552 19 conditioning conditioning NN cord-005453-4057qib7 552 20 were be VBD cord-005453-4057qib7 552 21 promising promising JJ cord-005453-4057qib7 552 22 ; ; : cord-005453-4057qib7 552 23 the the DT cord-005453-4057qib7 552 24 5-year 5-year CD cord-005453-4057qib7 552 25 OS OS NNP cord-005453-4057qib7 552 26 and and CC cord-005453-4057qib7 552 27 LFS lfs NN cord-005453-4057qib7 552 28 reached reach VBD cord-005453-4057qib7 552 29 73 73 CD cord-005453-4057qib7 552 30 % % NN cord-005453-4057qib7 552 31 and and CC cord-005453-4057qib7 552 32 62 62 CD cord-005453-4057qib7 552 33 % % NN cord-005453-4057qib7 552 34 and and CC cord-005453-4057qib7 552 35 the the DT cord-005453-4057qib7 552 36 5-year 5-year CD cord-005453-4057qib7 552 37 RI RI NNP cord-005453-4057qib7 552 38 and and CC cord-005453-4057qib7 552 39 TRM TRM NNP cord-005453-4057qib7 552 40 were be VBD cord-005453-4057qib7 552 41 33 33 CD cord-005453-4057qib7 552 42 % % NN cord-005453-4057qib7 552 43 and and CC cord-005453-4057qib7 552 44 5 5 CD cord-005453-4057qib7 552 45 % % NN cord-005453-4057qib7 552 46 , , , cord-005453-4057qib7 552 47 respectively respectively RB cord-005453-4057qib7 552 48 . . . cord-005453-4057qib7 553 1 Conclusions conclusion NNS cord-005453-4057qib7 553 2 : : : cord-005453-4057qib7 554 1 Our -PRON- PRP$ cord-005453-4057qib7 554 2 study study NN cord-005453-4057qib7 554 3 reveals reveal VBZ cord-005453-4057qib7 554 4 that that IN cord-005453-4057qib7 554 5 HSCT HSCT NNP cord-005453-4057qib7 554 6 with with IN cord-005453-4057qib7 554 7 sequential sequential JJ cord-005453-4057qib7 554 8 conditioning conditioning NN cord-005453-4057qib7 554 9 can can MD cord-005453-4057qib7 554 10 be be VB cord-005453-4057qib7 554 11 an an DT cord-005453-4057qib7 554 12 effective effective JJ cord-005453-4057qib7 554 13 and and CC cord-005453-4057qib7 554 14 tolerable tolerable JJ cord-005453-4057qib7 554 15 treatment treatment NN cord-005453-4057qib7 554 16 option option NN cord-005453-4057qib7 554 17 for for IN cord-005453-4057qib7 554 18 children child NNS cord-005453-4057qib7 554 19 with with IN cord-005453-4057qib7 554 20 relapsed relapse VBN cord-005453-4057qib7 554 21 / / SYM cord-005453-4057qib7 554 22 refractory refractory JJ cord-005453-4057qib7 554 23 acute acute JJ cord-005453-4057qib7 554 24 leukemia leukemia NN cord-005453-4057qib7 554 25 . . . cord-005453-4057qib7 555 1 The the DT cord-005453-4057qib7 555 2 treatment treatment NN cord-005453-4057qib7 555 3 strategies strategy NNS cord-005453-4057qib7 555 4 that that WDT cord-005453-4057qib7 555 5 focus focus VBP cord-005453-4057qib7 555 6 on on IN cord-005453-4057qib7 555 7 the the DT cord-005453-4057qib7 555 8 reduction reduction NN cord-005453-4057qib7 555 9 of of IN cord-005453-4057qib7 555 10 leukemia leukemia NN cord-005453-4057qib7 555 11 burden burden NN cord-005453-4057qib7 555 12 immediately immediately RB cord-005453-4057qib7 555 13 prior prior RB cord-005453-4057qib7 555 14 to to IN cord-005453-4057qib7 555 15 HSCT HSCT NNP cord-005453-4057qib7 555 16 may may MD cord-005453-4057qib7 555 17 contribute contribute VB cord-005453-4057qib7 555 18 to to IN cord-005453-4057qib7 555 19 the the DT cord-005453-4057qib7 555 20 induction induction NN cord-005453-4057qib7 555 21 of of IN cord-005453-4057qib7 555 22 long long JJ cord-005453-4057qib7 555 23 - - HYPH cord-005453-4057qib7 555 24 term term NN cord-005453-4057qib7 555 25 remissions remission NNS cord-005453-4057qib7 555 26 in in IN cord-005453-4057qib7 555 27 patients patient NNS cord-005453-4057qib7 555 28 with with IN cord-005453-4057qib7 555 29 high high JJ cord-005453-4057qib7 555 30 - - HYPH cord-005453-4057qib7 555 31 risk risk NN cord-005453-4057qib7 555 32 acute acute JJ cord-005453-4057qib7 555 33 leukemia leukemia NN cord-005453-4057qib7 555 34 . . . cord-005453-4057qib7 556 1 Disclosure disclosure NN cord-005453-4057qib7 556 2 : : : cord-005453-4057qib7 557 1 This this DT cord-005453-4057qib7 557 2 research research NN cord-005453-4057qib7 557 3 was be VBD cord-005453-4057qib7 557 4 funded fund VBN cord-005453-4057qib7 557 5 by by IN cord-005453-4057qib7 557 6 Japanese Japanese NNP cord-005453-4057qib7 557 7 Red Red NNP cord-005453-4057qib7 557 8 Cross Cross NNP cord-005453-4057qib7 557 9 , , , cord-005453-4057qib7 557 10 Nagoya Nagoya NNP cord-005453-4057qib7 557 11 1st 1st NN cord-005453-4057qib7 557 12 . . . cord-005453-4057qib7 558 1 Hospital hospital NN cord-005453-4057qib7 558 2 Research Research NNP cord-005453-4057qib7 558 3 Grant Grant NNP cord-005453-4057qib7 558 4 NFRCH18 NFRCH18 NNP cord-005453-4057qib7 558 5 - - HYPH cord-005453-4057qib7 558 6 0028 0028 CD cord-005453-4057qib7 558 7 . . . cord-005453-4057qib7 559 1 Use Use NNP cord-005453-4057qib7 559 2 of of IN cord-005453-4057qib7 559 3 blinatumomab blinatumomab NNS cord-005453-4057qib7 559 4 to to TO cord-005453-4057qib7 559 5 achieve achieve VB cord-005453-4057qib7 559 6 remission remission NN cord-005453-4057qib7 559 7 and and CC cord-005453-4057qib7 559 8 consolidation consolidation NN cord-005453-4057qib7 559 9 with with IN cord-005453-4057qib7 559 10 haploidentical haploidentical JJ cord-005453-4057qib7 559 11 transplant transplant NN cord-005453-4057qib7 559 12 with with IN cord-005453-4057qib7 559 13 cyclophosphamide cyclophosphamide NNP cord-005453-4057qib7 559 14 post post NN cord-005453-4057qib7 559 15 for for IN cord-005453-4057qib7 559 16 the the DT cord-005453-4057qib7 559 17 treatment treatment NN cord-005453-4057qib7 559 18 of of IN cord-005453-4057qib7 559 19 children child NNS cord-005453-4057qib7 559 20 with with IN cord-005453-4057qib7 559 21 refractory refractory JJ cord-005453-4057qib7 559 22 acute acute JJ cord-005453-4057qib7 559 23 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 559 24 leukemia leukemia NN cord-005453-4057qib7 559 25 ( ( -LRB- cord-005453-4057qib7 559 26 ALL all DT cord-005453-4057qib7 559 27 ) ) -RRB- cord-005453-4057qib7 560 1 Background background NN cord-005453-4057qib7 560 2 : : : cord-005453-4057qib7 561 1 Most Most JJS cord-005453-4057qib7 561 2 of of IN cord-005453-4057qib7 561 3 patients patient NNS cord-005453-4057qib7 561 4 with with IN cord-005453-4057qib7 561 5 ALL all DT cord-005453-4057qib7 561 6 in in IN cord-005453-4057qib7 561 7 relapse relapse NN cord-005453-4057qib7 561 8 or or CC cord-005453-4057qib7 561 9 refractory refractory JJ cord-005453-4057qib7 561 10 to to IN cord-005453-4057qib7 561 11 conventional conventional JJ cord-005453-4057qib7 561 12 treatment treatment NN cord-005453-4057qib7 561 13 have have VBP cord-005453-4057qib7 561 14 only only RB cord-005453-4057qib7 561 15 30 30 CD cord-005453-4057qib7 561 16 % % NN cord-005453-4057qib7 561 17 possibilities possibility NNS cord-005453-4057qib7 561 18 to to TO cord-005453-4057qib7 561 19 achieve achieve VB cord-005453-4057qib7 561 20 long long JJ cord-005453-4057qib7 561 21 term term NN cord-005453-4057qib7 561 22 remission remission NN cord-005453-4057qib7 561 23 . . . cord-005453-4057qib7 562 1 This this DT cord-005453-4057qib7 562 2 report report NN cord-005453-4057qib7 562 3 refers refer VBZ cord-005453-4057qib7 562 4 to to IN cord-005453-4057qib7 562 5 the the DT cord-005453-4057qib7 562 6 therapeutic therapeutic JJ cord-005453-4057qib7 562 7 efficacy efficacy NN cord-005453-4057qib7 562 8 and and CC cord-005453-4057qib7 562 9 adverse adverse JJ cord-005453-4057qib7 562 10 events event NNS cord-005453-4057qib7 562 11 from from IN cord-005453-4057qib7 562 12 the the DT cord-005453-4057qib7 562 13 blinatumomab blinatumomab NNS cord-005453-4057qib7 562 14 to to TO cord-005453-4057qib7 562 15 achieve achieve VB cord-005453-4057qib7 562 16 molecular molecular JJ cord-005453-4057qib7 562 17 remission remission NN cord-005453-4057qib7 562 18 in in IN cord-005453-4057qib7 562 19 patients patient NNS cord-005453-4057qib7 562 20 with with IN cord-005453-4057qib7 562 21 pre pre JJ cord-005453-4057qib7 562 22 - - NN cord-005453-4057qib7 562 23 B B NNP cord-005453-4057qib7 562 24 CD19 CD19 NNP cord-005453-4057qib7 562 25 + + CC cord-005453-4057qib7 562 26 which which WDT cord-005453-4057qib7 562 27 lead lead VBP cord-005453-4057qib7 562 28 to to IN cord-005453-4057qib7 562 29 haploidentical haploidentical VB cord-005453-4057qib7 562 30 with with IN cord-005453-4057qib7 562 31 cyclophosphamide cyclophosphamide JJ cord-005453-4057qib7 562 32 post post NN cord-005453-4057qib7 562 33 transplant transplant NN cord-005453-4057qib7 562 34 as as IN cord-005453-4057qib7 562 35 a a DT cord-005453-4057qib7 562 36 consolidation consolidation NN cord-005453-4057qib7 562 37 . . . cord-005453-4057qib7 563 1 Methods method NNS cord-005453-4057qib7 563 2 : : : cord-005453-4057qib7 564 1 A a DT cord-005453-4057qib7 564 2 pilot pilot NN cord-005453-4057qib7 564 3 study study NN cord-005453-4057qib7 564 4 was be VBD cord-005453-4057qib7 564 5 conducted conduct VBN cord-005453-4057qib7 564 6 in in IN cord-005453-4057qib7 564 7 children child NNS cord-005453-4057qib7 564 8 with with IN cord-005453-4057qib7 564 9 refractory refractory JJ cord-005453-4057qib7 564 10 ALL all DT cord-005453-4057qib7 564 11 preB preB NNS cord-005453-4057qib7 564 12 - - : cord-005453-4057qib7 564 13 CD19 CD19 NNP cord-005453-4057qib7 564 14 + + CC cord-005453-4057qib7 564 15 . . . cord-005453-4057qib7 565 1 As as IN cord-005453-4057qib7 565 2 a a DT cord-005453-4057qib7 565 3 strategy strategy NN cord-005453-4057qib7 565 4 to to TO cord-005453-4057qib7 565 5 achieved achieve VBN cord-005453-4057qib7 565 6 remission remission NN cord-005453-4057qib7 565 7 blinatumomab blinatumomab NNS cord-005453-4057qib7 565 8 was be VBD cord-005453-4057qib7 565 9 used use VBN cord-005453-4057qib7 565 10 at at IN cord-005453-4057qib7 565 11 a a DT cord-005453-4057qib7 565 12 dose dose NN cord-005453-4057qib7 565 13 10 10 CD cord-005453-4057qib7 565 14 μg μg NNP cord-005453-4057qib7 565 15 / / SYM cord-005453-4057qib7 565 16 m2 m2 NNP cord-005453-4057qib7 565 17 for for IN cord-005453-4057qib7 565 18 continous continous JJ cord-005453-4057qib7 565 19 infusion infusion NN cord-005453-4057qib7 565 20 of of IN cord-005453-4057qib7 565 21 48 48 CD cord-005453-4057qib7 565 22 hours hour NNS cord-005453-4057qib7 565 23 , , , cord-005453-4057qib7 565 24 increasing increase VBG cord-005453-4057qib7 565 25 the the DT cord-005453-4057qib7 565 26 dose dose NN cord-005453-4057qib7 565 27 to to IN cord-005453-4057qib7 565 28 15 15 CD cord-005453-4057qib7 565 29 μg μg NNP cord-005453-4057qib7 565 30 / / SYM cord-005453-4057qib7 565 31 m2 m2 NNP cord-005453-4057qib7 565 32 during during IN cord-005453-4057qib7 565 33 28 28 CD cord-005453-4057qib7 565 34 days day NNS cord-005453-4057qib7 565 35 , , , cord-005453-4057qib7 565 36 patients patient NNS cord-005453-4057qib7 565 37 with with IN cord-005453-4057qib7 565 38 a a DT cord-005453-4057qib7 565 39 MRD MRD NNP cord-005453-4057qib7 565 40 of of IN cord-005453-4057qib7 565 41 < < XX cord-005453-4057qib7 565 42 0.002 0.002 CD cord-005453-4057qib7 565 43 Log Log NNP cord-005453-4057qib7 565 44 , , , cord-005453-4057qib7 565 45 after after IN cord-005453-4057qib7 565 46 2 2 CD cord-005453-4057qib7 565 47 cycles cycle NNS cord-005453-4057qib7 565 48 received receive VBD cord-005453-4057qib7 565 49 an an DT cord-005453-4057qib7 565 50 haploidentical haploidentical JJ cord-005453-4057qib7 565 51 bone bone NN cord-005453-4057qib7 565 52 marrow marrow NN cord-005453-4057qib7 565 53 transplant transplant NN cord-005453-4057qib7 565 54 as as IN cord-005453-4057qib7 565 55 a a DT cord-005453-4057qib7 565 56 consolidation consolidation NN cord-005453-4057qib7 565 57 , , , cord-005453-4057qib7 565 58 the the DT cord-005453-4057qib7 565 59 conditioning conditioning NN cord-005453-4057qib7 565 60 regimen regimen NN cord-005453-4057qib7 565 61 was be VBD cord-005453-4057qib7 565 62 with with IN cord-005453-4057qib7 565 63 total total JJ cord-005453-4057qib7 565 64 body body NN cord-005453-4057qib7 565 65 irradiation irradiation NN cord-005453-4057qib7 565 66 scheme scheme NN cord-005453-4057qib7 565 67 at at IN cord-005453-4057qib7 565 68 200 200 CD cord-005453-4057qib7 565 69 cGy cGy NNS cord-005453-4057qib7 565 70 / / SYM cord-005453-4057qib7 565 71 day/3 day/3 JJ cord-005453-4057qib7 565 72 days day NNS cord-005453-4057qib7 565 73 , , , cord-005453-4057qib7 565 74 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 565 75 and and CC cord-005453-4057qib7 565 76 etoposide etoposide RB cord-005453-4057qib7 565 77 . . . cord-005453-4057qib7 566 1 Receiving receive VBG cord-005453-4057qib7 566 2 prophylaxis prophylaxis NN cord-005453-4057qib7 566 3 for for IN cord-005453-4057qib7 566 4 GVHD GVHD NNP cord-005453-4057qib7 566 5 with with IN cord-005453-4057qib7 566 6 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 566 7 . . . cord-005453-4057qib7 567 1 Results result NNS cord-005453-4057qib7 567 2 : : : cord-005453-4057qib7 568 1 A a DT cord-005453-4057qib7 568 2 total total NN cord-005453-4057qib7 568 3 of of IN cord-005453-4057qib7 568 4 10 10 CD cord-005453-4057qib7 568 5 patients patient NNS cord-005453-4057qib7 568 6 were be VBD cord-005453-4057qib7 568 7 included include VBN cord-005453-4057qib7 568 8 , , , cord-005453-4057qib7 568 9 seven seven CD cord-005453-4057qib7 568 10 of of IN cord-005453-4057qib7 568 11 them -PRON- PRP cord-005453-4057qib7 568 12 achieved achieve VBD cord-005453-4057qib7 568 13 complete complete JJ cord-005453-4057qib7 568 14 remission remission NN cord-005453-4057qib7 568 15 after after IN cord-005453-4057qib7 568 16 2 2 CD cord-005453-4057qib7 568 17 cycles cycle NNS cord-005453-4057qib7 568 18 of of IN cord-005453-4057qib7 568 19 blinatumomab blinatumomab NNS cord-005453-4057qib7 568 20 , , , cord-005453-4057qib7 568 21 one one CD cord-005453-4057qib7 568 22 with with IN cord-005453-4057qib7 568 23 partial partial JJ cord-005453-4057qib7 568 24 remission remission NN cord-005453-4057qib7 568 25 ( ( -LRB- cord-005453-4057qib7 568 26 Table table NN cord-005453-4057qib7 568 27 1 1 CD cord-005453-4057qib7 568 28 ) ) -RRB- cord-005453-4057qib7 568 29 , , , cord-005453-4057qib7 568 30 these these DT cord-005453-4057qib7 568 31 seven seven CD cord-005453-4057qib7 568 32 patients patient NNS cord-005453-4057qib7 568 33 , , , cord-005453-4057qib7 568 34 six six CD cord-005453-4057qib7 568 35 received receive VBD cord-005453-4057qib7 568 36 an an DT cord-005453-4057qib7 568 37 haploidentic haploidentic JJ cord-005453-4057qib7 568 38 transplant transplant NN cord-005453-4057qib7 568 39 achieving achieve VBG cord-005453-4057qib7 568 40 graft graft NN cord-005453-4057qib7 568 41 in in IN cord-005453-4057qib7 568 42 6 6 CD cord-005453-4057qib7 568 43 of of IN cord-005453-4057qib7 568 44 the the DT cord-005453-4057qib7 568 45 transplanted transplanted JJ cord-005453-4057qib7 568 46 patients patient NNS cord-005453-4057qib7 568 47 . . . cord-005453-4057qib7 569 1 One one CD cord-005453-4057qib7 569 2 patient patient NN cord-005453-4057qib7 569 3 had have VBD cord-005453-4057qib7 569 4 a a DT cord-005453-4057qib7 569 5 bone bone NN cord-005453-4057qib7 569 6 marrow marrow NN cord-005453-4057qib7 569 7 relapse relapse NN cord-005453-4057qib7 569 8 in in IN cord-005453-4057qib7 569 9 the the DT cord-005453-4057qib7 569 10 first first JJ cord-005453-4057qib7 569 11 6 6 CD cord-005453-4057qib7 569 12 months month NNS cord-005453-4057qib7 569 13 of of IN cord-005453-4057qib7 569 14 the the DT cord-005453-4057qib7 569 15 follow follow NN cord-005453-4057qib7 569 16 - - HYPH cord-005453-4057qib7 569 17 up up NN cord-005453-4057qib7 569 18 and and CC cord-005453-4057qib7 569 19 5 5 CD cord-005453-4057qib7 569 20 patients patient NNS cord-005453-4057qib7 569 21 are be VBP cord-005453-4057qib7 569 22 free free JJ cord-005453-4057qib7 569 23 of of IN cord-005453-4057qib7 569 24 disease disease NN cord-005453-4057qib7 569 25 with with IN cord-005453-4057qib7 569 26 a a DT cord-005453-4057qib7 569 27 follow follow NN cord-005453-4057qib7 569 28 - - HYPH cord-005453-4057qib7 569 29 up up NN cord-005453-4057qib7 569 30 to to TO cord-005453-4057qib7 569 31 20 20 CD cord-005453-4057qib7 569 32 months month NNS cord-005453-4057qib7 569 33 ( ( -LRB- cord-005453-4057qib7 569 34 figure figure NN cord-005453-4057qib7 569 35 1 1 CD cord-005453-4057qib7 569 36 ) ) -RRB- cord-005453-4057qib7 569 37 . . . cord-005453-4057qib7 570 1 As as IN cord-005453-4057qib7 570 2 a a DT cord-005453-4057qib7 570 3 acute acute JJ cord-005453-4057qib7 570 4 complication complication NN cord-005453-4057qib7 570 5 the the DT cord-005453-4057qib7 570 6 10 10 CD cord-005453-4057qib7 570 7 patients patient NNS cord-005453-4057qib7 570 8 presented present VBD cord-005453-4057qib7 570 9 cytokine cytokine NN cord-005453-4057qib7 570 10 release release NN cord-005453-4057qib7 570 11 syndrome syndrome NN cord-005453-4057qib7 570 12 , , , cord-005453-4057qib7 570 13 during during IN cord-005453-4057qib7 570 14 the the DT cord-005453-4057qib7 570 15 infusion infusion NN cord-005453-4057qib7 570 16 of of IN cord-005453-4057qib7 570 17 blinatumumab blinatumumab NNP cord-005453-4057qib7 570 18 10 10 CD cord-005453-4057qib7 570 19 patients patient NNS cord-005453-4057qib7 570 20 presented present VBD cord-005453-4057qib7 570 21 tachycardia tachycardia NN cord-005453-4057qib7 570 22 ( ( -LRB- cord-005453-4057qib7 570 23 Table Table NNP cord-005453-4057qib7 570 24 3 3 CD cord-005453-4057qib7 570 25 ) ) -RRB- cord-005453-4057qib7 570 26 and and CC cord-005453-4057qib7 570 27 the the DT cord-005453-4057qib7 570 28 6 6 CD cord-005453-4057qib7 570 29 patients patient NNS cord-005453-4057qib7 570 30 presented present VBD cord-005453-4057qib7 570 31 aGVHD agvhd NN cord-005453-4057qib7 570 32 after after IN cord-005453-4057qib7 570 33 HSCT HSCT NNP cord-005453-4057qib7 570 34 ( ( -LRB- cord-005453-4057qib7 570 35 5 5 CD cord-005453-4057qib7 570 36 grade grade NN cord-005453-4057qib7 570 37 I I NNP cord-005453-4057qib7 570 38 - - HYPH cord-005453-4057qib7 570 39 II II NNP cord-005453-4057qib7 570 40 and and CC cord-005453-4057qib7 570 41 I -PRON- PRP cord-005453-4057qib7 570 42 grade grade NN cord-005453-4057qib7 570 43 IV IV NNP cord-005453-4057qib7 570 44 ) ) -RRB- cord-005453-4057qib7 570 45 . . . cord-005453-4057qib7 571 1 Conclusions conclusion NNS cord-005453-4057qib7 571 2 : : : cord-005453-4057qib7 572 1 Allogeneic allogeneic IN cord-005453-4057qib7 572 2 bone bone NN cord-005453-4057qib7 572 3 marrow marrow NN cord-005453-4057qib7 572 4 transplant transplant NN cord-005453-4057qib7 572 5 constitutes constitute VBZ cord-005453-4057qib7 572 6 a a DT cord-005453-4057qib7 572 7 treatment treatment NN cord-005453-4057qib7 572 8 option option NN cord-005453-4057qib7 572 9 on on IN cord-005453-4057qib7 572 10 those those DT cord-005453-4057qib7 572 11 patients patient NNS cord-005453-4057qib7 572 12 that that IN cord-005453-4057qib7 572 13 relapse relapse VBP cord-005453-4057qib7 572 14 or or CC cord-005453-4057qib7 572 15 become become VBP cord-005453-4057qib7 572 16 refractory refractory JJ cord-005453-4057qib7 572 17 to to IN cord-005453-4057qib7 572 18 treatment treatment NN cord-005453-4057qib7 572 19 , , , cord-005453-4057qib7 572 20 one one CD cord-005453-4057qib7 572 21 of of IN cord-005453-4057qib7 572 22 the the DT cord-005453-4057qib7 572 23 major major JJ cord-005453-4057qib7 572 24 problem problem NN cord-005453-4057qib7 572 25 is be VBZ cord-005453-4057qib7 572 26 basically basically RB cord-005453-4057qib7 572 27 to to TO cord-005453-4057qib7 572 28 identify identify VB cord-005453-4057qib7 572 29 a a DT cord-005453-4057qib7 572 30 HLA HLA NNP cord-005453-4057qib7 572 31 - - HYPH cord-005453-4057qib7 572 32 identical identical JJ cord-005453-4057qib7 572 33 donor donor NN cord-005453-4057qib7 572 34 , , , cord-005453-4057qib7 572 35 the the DT cord-005453-4057qib7 572 36 alternative alternative NN cord-005453-4057qib7 572 37 is be VBZ cord-005453-4057qib7 572 38 an an DT cord-005453-4057qib7 572 39 haploidentical haploidentical JJ cord-005453-4057qib7 572 40 donor donor NN cord-005453-4057qib7 572 41 . . . cord-005453-4057qib7 573 1 The the DT cord-005453-4057qib7 573 2 most most RBS cord-005453-4057qib7 573 3 important important JJ cord-005453-4057qib7 573 4 factor factor NN cord-005453-4057qib7 573 5 to to TO cord-005453-4057qib7 573 6 get get VB cord-005453-4057qib7 573 7 these these DT cord-005453-4057qib7 573 8 results result NNS cord-005453-4057qib7 573 9 is be VBZ cord-005453-4057qib7 573 10 the the DT cord-005453-4057qib7 573 11 disease disease NN cord-005453-4057qib7 573 12 status status NN cord-005453-4057qib7 573 13 before before IN cord-005453-4057qib7 573 14 transplant transplant NN cord-005453-4057qib7 573 15 . . . cord-005453-4057qib7 574 1 The the DT cord-005453-4057qib7 574 2 use use NN cord-005453-4057qib7 574 3 of of IN cord-005453-4057qib7 574 4 blinatumomab blinatumomab NN cord-005453-4057qib7 574 5 has have VBZ cord-005453-4057qib7 574 6 proven prove VBN cord-005453-4057qib7 574 7 to to TO cord-005453-4057qib7 574 8 be be VB cord-005453-4057qib7 574 9 effective effective JJ cord-005453-4057qib7 574 10 in in IN cord-005453-4057qib7 574 11 achieving achieve VBG cord-005453-4057qib7 574 12 remission remission NN cord-005453-4057qib7 574 13 in in IN cord-005453-4057qib7 574 14 relapse relapse NN cord-005453-4057qib7 575 1 Acute acute JJ cord-005453-4057qib7 575 2 Linfoblastic Linfoblastic NNP cord-005453-4057qib7 575 3 Leukemia Leukemia NNP cord-005453-4057qib7 575 4 pre pre NN cord-005453-4057qib7 575 5 - - JJ cord-005453-4057qib7 575 6 B b NN cord-005453-4057qib7 575 7 CD CD NNP cord-005453-4057qib7 575 8 19 19 CD cord-005453-4057qib7 575 9 + + CC cord-005453-4057qib7 575 10 or or CC cord-005453-4057qib7 575 11 refractory refractory JJ cord-005453-4057qib7 575 12 to to IN cord-005453-4057qib7 575 13 treatment treatment NN cord-005453-4057qib7 575 14 . . . cord-005453-4057qib7 576 1 CHARACTERISTICS CHARACTERISTICS NNP cord-005453-4057qib7 576 2 Nº Nº NNP cord-005453-4057qib7 576 3 % % NN cord-005453-4057qib7 577 1 Male male JJ cord-005453-4057qib7 577 2 4 4 CD cord-005453-4057qib7 577 3 40 40 CD cord-005453-4057qib7 577 4 % % NN cord-005453-4057qib7 577 5 Median median JJ cord-005453-4057qib7 577 6 age age NN cord-005453-4057qib7 577 7 at at IN cord-005453-4057qib7 577 8 diagnosis diagnosis NN cord-005453-4057qib7 577 9 , , , cord-005453-4057qib7 577 10 ( ( -LRB- cord-005453-4057qib7 577 11 range range NN cord-005453-4057qib7 577 12 ) ) -RRB- cord-005453-4057qib7 577 13 , , , cord-005453-4057qib7 577 14 years year NNS cord-005453-4057qib7 577 15 9 9 CD cord-005453-4057qib7 577 16 . . . cord-005453-4057qib7 577 17 22 22 CD cord-005453-4057qib7 578 1 ( ( -LRB- cord-005453-4057qib7 578 2 7 7 CD cord-005453-4057qib7 578 3 - - SYM cord-005453-4057qib7 578 4 12 12 CD cord-005453-4057qib7 578 5 ) ) -RRB- cord-005453-4057qib7 578 6 Status status NN cord-005453-4057qib7 578 7 of of IN cord-005453-4057qib7 578 8 disease disease NN cord-005453-4057qib7 578 9 2 2 CD cord-005453-4057qib7 578 10 o o NN cord-005453-4057qib7 578 11 + + SYM cord-005453-4057qib7 578 12 3 3 CD cord-005453-4057qib7 578 13 relapse relapse NN cord-005453-4057qib7 578 14 6 6 CD cord-005453-4057qib7 578 15 60 60 CD cord-005453-4057qib7 578 16 % % NN cord-005453-4057qib7 578 17 Refractory refractory JJ cord-005453-4057qib7 578 18 to to IN cord-005453-4057qib7 578 19 primary primary JJ cord-005453-4057qib7 578 20 or or CC cord-005453-4057qib7 578 21 salvage salvage VB cord-005453-4057qib7 578 22 therapy therapy NN cord-005453-4057qib7 579 1 4 4 CD cord-005453-4057qib7 579 2 40 40 CD cord-005453-4057qib7 579 3 % % NN cord-005453-4057qib7 579 4 Complete complete JJ cord-005453-4057qib7 579 5 remission remission NN cord-005453-4057qib7 579 6 after after IN cord-005453-4057qib7 579 7 Blinatumomab Blinatumomab NNP cord-005453-4057qib7 580 1 7 7 CD cord-005453-4057qib7 580 2 70 70 CD cord-005453-4057qib7 580 3 % % NN cord-005453-4057qib7 580 4 Partial partial JJ cord-005453-4057qib7 580 5 remission remission NN cord-005453-4057qib7 580 6 after after IN cord-005453-4057qib7 580 7 Blinatumomab Blinatumomab NNP cord-005453-4057qib7 580 8 1 1 CD cord-005453-4057qib7 580 9 10 10 CD cord-005453-4057qib7 580 10 % % NN cord-005453-4057qib7 580 11 Active active JJ cord-005453-4057qib7 580 12 disease disease NN cord-005453-4057qib7 580 13 2 2 CD cord-005453-4057qib7 580 14 20 20 CD cord-005453-4057qib7 580 15 % % NN cord-005453-4057qib7 580 16 [ [ -LRB- cord-005453-4057qib7 580 17 [ [ -LRB- cord-005453-4057qib7 580 18 P031 P031 NNP cord-005453-4057qib7 580 19 Table table NN cord-005453-4057qib7 580 20 ] ] -RRB- cord-005453-4057qib7 581 1 1 1 LS cord-005453-4057qib7 581 2 . . . cord-005453-4057qib7 582 1 Table table NN cord-005453-4057qib7 582 2 N n CD cord-005453-4057qib7 582 3 ° ° NN cord-005453-4057qib7 582 4 1 1 CD cord-005453-4057qib7 582 5 . . . cord-005453-4057qib7 583 1 Demographic demographic JJ cord-005453-4057qib7 583 2 characteristics characteristic NNS cord-005453-4057qib7 583 3 of of IN cord-005453-4057qib7 583 4 patients patient NNS cord-005453-4057qib7 583 5 undergoing undergo VBG cord-005453-4057qib7 583 6 Blinatumomab Blinatumomab NNP cord-005453-4057qib7 583 7 ( ( -LRB- cord-005453-4057qib7 583 8 n=10 n=10 NNP cord-005453-4057qib7 583 9 ) ) -RRB- cord-005453-4057qib7 583 10 ] ] -RRB- cord-005453-4057qib7 584 1 Disclosure disclosure NN cord-005453-4057qib7 584 2 : : : cord-005453-4057qib7 584 3 A. A. NNP cord-005453-4057qib7 584 4 Olaya Olaya NNP cord-005453-4057qib7 584 5 - - HYPH cord-005453-4057qib7 584 6 Vargas Vargas NNP cord-005453-4057qib7 584 7 , , , cord-005453-4057qib7 584 8 R. R. NNP cord-005453-4057qib7 584 9 Rivera Rivera NNP cord-005453-4057qib7 584 10 - - HYPH cord-005453-4057qib7 584 11 Luna Luna NNP cord-005453-4057qib7 584 12 , , , cord-005453-4057qib7 584 13 Y. Y. NNP cord-005453-4057qib7 584 14 Melchor Melchor NNP cord-005453-4057qib7 584 15 - - HYPH cord-005453-4057qib7 584 16 Vidal Vidal NNP cord-005453-4057qib7 584 17 , , , cord-005453-4057qib7 584 18 H. H. NNP cord-005453-4057qib7 584 19 Salazar Salazar NNP cord-005453-4057qib7 584 20 - - HYPH cord-005453-4057qib7 584 21 Rosales Rosales NNP cord-005453-4057qib7 584 22 , , , cord-005453-4057qib7 584 23 G. G. NNP cord-005453-4057qib7 584 24 Lopez Lopez NNP cord-005453-4057qib7 584 25 - - HYPH cord-005453-4057qib7 584 26 Hernandez Hernandez NNP cord-005453-4057qib7 584 27 , , , cord-005453-4057qib7 584 28 N. N. NNP cord-005453-4057qib7 584 29 Ramirez Ramirez NNP cord-005453-4057qib7 584 30 - - HYPH cord-005453-4057qib7 584 31 Uribe Uribe NNP cord-005453-4057qib7 584 32 . . . cord-005453-4057qib7 585 1 We -PRON- PRP cord-005453-4057qib7 585 2 wish wish VBP cord-005453-4057qib7 585 3 to to TO cord-005453-4057qib7 585 4 confirm confirm VB cord-005453-4057qib7 585 5 that that IN cord-005453-4057qib7 585 6 there there EX cord-005453-4057qib7 585 7 are be VBP cord-005453-4057qib7 585 8 no no DT cord-005453-4057qib7 585 9 known know VBN cord-005453-4057qib7 585 10 conflicts conflict NNS cord-005453-4057qib7 585 11 of of IN cord-005453-4057qib7 585 12 interest interest NN cord-005453-4057qib7 585 13 associated associate VBN cord-005453-4057qib7 585 14 with with IN cord-005453-4057qib7 585 15 this this DT cord-005453-4057qib7 585 16 abstact abstact JJ cord-005453-4057qib7 585 17 , , , cord-005453-4057qib7 585 18 the the DT cord-005453-4057qib7 585 19 only only JJ cord-005453-4057qib7 585 20 financial financial JJ cord-005453-4057qib7 585 21 support support NN cord-005453-4057qib7 585 22 was be VBD cord-005453-4057qib7 585 23 provided provide VBN cord-005453-4057qib7 585 24 by by IN cord-005453-4057qib7 585 25 Mexican Mexican NNP cord-005453-4057qib7 585 26 Associations Associations NNPS cord-005453-4057qib7 585 27 that that IN cord-005453-4057qib7 585 28 helping help VBG cord-005453-4057qib7 585 29 children child NNS cord-005453-4057qib7 585 30 wiht wiht VB cord-005453-4057qib7 585 31 cancer cancer NN cord-005453-4057qib7 585 32 in in IN cord-005453-4057qib7 585 33 a a DT cord-005453-4057qib7 585 34 few few JJ cord-005453-4057qib7 585 35 patients patient NNS cord-005453-4057qib7 585 36 . . . cord-005453-4057qib7 586 1 Sequential sequential JJ cord-005453-4057qib7 586 2 high high JJ cord-005453-4057qib7 586 3 - - HYPH cord-005453-4057qib7 586 4 dose dose NN cord-005453-4057qib7 586 5 chemotherapy chemotherapy NN cord-005453-4057qib7 586 6 reinduction reinduction NN cord-005453-4057qib7 586 7 followed follow VBN cord-005453-4057qib7 586 8 by by IN cord-005453-4057qib7 586 9 myeloablative myeloablative NNP cord-005453-4057qib7 586 10 allogeneic allogeneic NN cord-005453-4057qib7 586 11 transplant transplant NN cord-005453-4057qib7 586 12 for for IN cord-005453-4057qib7 586 13 active active JJ cord-005453-4057qib7 586 14 acute acute JJ cord-005453-4057qib7 586 15 myeloid myeloid NN cord-005453-4057qib7 586 16 leukemias leukemias RB cord-005453-4057qib7 586 17 Methods method NNS cord-005453-4057qib7 586 18 : : : cord-005453-4057qib7 586 19 At at IN cord-005453-4057qib7 586 20 our -PRON- PRP$ cord-005453-4057qib7 586 21 Center Center NNP cord-005453-4057qib7 586 22 , , , cord-005453-4057qib7 586 23 27 27 CD cord-005453-4057qib7 586 24 relapsed relapse VBD cord-005453-4057qib7 586 25 / / SYM cord-005453-4057qib7 586 26 refractory refractory JJ cord-005453-4057qib7 586 27 AML AML NNP cord-005453-4057qib7 586 28 patients patient NNS cord-005453-4057qib7 586 29 were be VBD cord-005453-4057qib7 586 30 transplanted transplant VBN cord-005453-4057qib7 586 31 during during IN cord-005453-4057qib7 586 32 chemo chemo NN cord-005453-4057qib7 586 33 - - HYPH cord-005453-4057qib7 586 34 induced induce VBN cord-005453-4057qib7 586 35 neutropenia neutropenia NN cord-005453-4057qib7 586 36 after after IN cord-005453-4057qib7 586 37 high high JJ cord-005453-4057qib7 586 38 - - HYPH cord-005453-4057qib7 586 39 dose dose NN cord-005453-4057qib7 586 40 salvage salvage NN cord-005453-4057qib7 586 41 chemotherapy chemotherapy NN cord-005453-4057qib7 586 42 . . . cord-005453-4057qib7 587 1 Median median JJ cord-005453-4057qib7 587 2 age age NN cord-005453-4057qib7 587 3 at at IN cord-005453-4057qib7 587 4 transplant transplant NN cord-005453-4057qib7 587 5 was be VBD cord-005453-4057qib7 587 6 52 52 CD cord-005453-4057qib7 587 7 years year NNS cord-005453-4057qib7 588 1 ( ( -LRB- cord-005453-4057qib7 588 2 range range NNP cord-005453-4057qib7 588 3 21 21 CD cord-005453-4057qib7 588 4 - - SYM cord-005453-4057qib7 588 5 62 62 CD cord-005453-4057qib7 588 6 ) ) -RRB- cord-005453-4057qib7 588 7 . . . cord-005453-4057qib7 589 1 Patients patient NNS cord-005453-4057qib7 589 2 suffered suffer VBD cord-005453-4057qib7 589 3 from from IN cord-005453-4057qib7 589 4 de de NNP cord-005453-4057qib7 589 5 novo novo NNP cord-005453-4057qib7 589 6 ( ( -LRB- cord-005453-4057qib7 589 7 n= n= NNP cord-005453-4057qib7 589 8 18/27 18/27 CD cord-005453-4057qib7 589 9 , , , cord-005453-4057qib7 589 10 67 67 CD cord-005453-4057qib7 589 11 % % NN cord-005453-4057qib7 589 12 ) ) -RRB- cord-005453-4057qib7 589 13 or or CC cord-005453-4057qib7 589 14 secondary secondary JJ cord-005453-4057qib7 589 15 AML AML NNP cord-005453-4057qib7 589 16 ( ( -LRB- cord-005453-4057qib7 589 17 n=9/ n=9/ NNP cord-005453-4057qib7 589 18 27 27 CD cord-005453-4057qib7 589 19 , , , cord-005453-4057qib7 589 20 33 33 CD cord-005453-4057qib7 589 21 % % NN cord-005453-4057qib7 589 22 ) ) -RRB- cord-005453-4057qib7 589 23 . . . cord-005453-4057qib7 590 1 Genetic genetic JJ cord-005453-4057qib7 590 2 risk risk NN cord-005453-4057qib7 590 3 stratification stratification NN cord-005453-4057qib7 590 4 was be VBD cord-005453-4057qib7 590 5 reported report VBN cord-005453-4057qib7 590 6 using use VBG cord-005453-4057qib7 590 7 stardardized stardardize VBN cord-005453-4057qib7 590 8 groups group NNS cord-005453-4057qib7 590 9 proposed propose VBN cord-005453-4057qib7 590 10 by by IN cord-005453-4057qib7 590 11 the the DT cord-005453-4057qib7 590 12 European European NNP cord-005453-4057qib7 590 13 Leukemia Leukemia NNP cord-005453-4057qib7 590 14 Net Net NNP cord-005453-4057qib7 590 15 ( ( -LRB- cord-005453-4057qib7 590 16 ELN ELN NNP cord-005453-4057qib7 590 17 ) ) -RRB- cord-005453-4057qib7 590 18 in in IN cord-005453-4057qib7 590 19 2010 2010 CD cord-005453-4057qib7 590 20 . . . cord-005453-4057qib7 591 1 Favorable favorable JJ cord-005453-4057qib7 591 2 , , , cord-005453-4057qib7 591 3 Intermediate Intermediate NNP cord-005453-4057qib7 591 4 I I NNP cord-005453-4057qib7 591 5 and and CC cord-005453-4057qib7 591 6 II II NNP cord-005453-4057qib7 591 7 and and CC cord-005453-4057qib7 591 8 Adverse adverse JJ cord-005453-4057qib7 591 9 risk risk NN cord-005453-4057qib7 591 10 category category NN cord-005453-4057qib7 591 11 at at IN cord-005453-4057qib7 591 12 diagnosis diagnosis NN cord-005453-4057qib7 591 13 was be VBD cord-005453-4057qib7 591 14 observed observe VBN cord-005453-4057qib7 591 15 in in IN cord-005453-4057qib7 591 16 1/27 1/27 CD cord-005453-4057qib7 591 17 ( ( -LRB- cord-005453-4057qib7 591 18 4 4 CD cord-005453-4057qib7 591 19 % % NN cord-005453-4057qib7 591 20 ) ) -RRB- cord-005453-4057qib7 591 21 , , , cord-005453-4057qib7 591 22 19/27 19/27 CD cord-005453-4057qib7 591 23 ( ( -LRB- cord-005453-4057qib7 591 24 70 70 CD cord-005453-4057qib7 591 25 % % NN cord-005453-4057qib7 591 26 ) ) -RRB- cord-005453-4057qib7 591 27 , , , cord-005453-4057qib7 591 28 7/27 7/27 CD cord-005453-4057qib7 591 29 patients patient NNS cord-005453-4057qib7 591 30 ( ( -LRB- cord-005453-4057qib7 591 31 26 26 CD cord-005453-4057qib7 591 32 % % NN cord-005453-4057qib7 591 33 ) ) -RRB- cord-005453-4057qib7 591 34 respectively respectively RB cord-005453-4057qib7 591 35 . . . cord-005453-4057qib7 592 1 All all DT cord-005453-4057qib7 592 2 patients patient NNS cord-005453-4057qib7 592 3 had have VBD cord-005453-4057qib7 592 4 active active JJ cord-005453-4057qib7 592 5 disease disease NN cord-005453-4057qib7 592 6 at at IN cord-005453-4057qib7 592 7 the the DT cord-005453-4057qib7 592 8 time time NN cord-005453-4057qib7 592 9 of of IN cord-005453-4057qib7 592 10 Sequential Sequential NNP cord-005453-4057qib7 592 11 Therapy therapy NN cord-005453-4057qib7 592 12 and and CC cord-005453-4057qib7 592 13 median median JJ cord-005453-4057qib7 592 14 marrow marrow NN cord-005453-4057qib7 592 15 blast blast NN cord-005453-4057qib7 592 16 count count NN cord-005453-4057qib7 592 17 was be VBD cord-005453-4057qib7 592 18 25 25 CD cord-005453-4057qib7 592 19 % % NN cord-005453-4057qib7 592 20 ( ( -LRB- cord-005453-4057qib7 592 21 range range NNP cord-005453-4057qib7 592 22 7 7 CD cord-005453-4057qib7 592 23 - - SYM cord-005453-4057qib7 592 24 88 88 CD cord-005453-4057qib7 592 25 % % NN cord-005453-4057qib7 592 26 ) ) -RRB- cord-005453-4057qib7 592 27 . . . cord-005453-4057qib7 593 1 Patients patient NNS cord-005453-4057qib7 593 2 received receive VBD cord-005453-4057qib7 593 3 a a DT cord-005453-4057qib7 593 4 high high JJ cord-005453-4057qib7 593 5 - - HYPH cord-005453-4057qib7 593 6 dose dose NN cord-005453-4057qib7 593 7 Cytarabine Cytarabine NNP cord-005453-4057qib7 593 8 based base VBN cord-005453-4057qib7 593 9 ( ( -LRB- cord-005453-4057qib7 593 10 MEC MEC NNP cord-005453-4057qib7 593 11 in in IN cord-005453-4057qib7 593 12 17/ 17/ CD cord-005453-4057qib7 593 13 27 27 CD cord-005453-4057qib7 593 14 , , , cord-005453-4057qib7 593 15 63 63 CD cord-005453-4057qib7 593 16 % % NN cord-005453-4057qib7 593 17 ) ) -RRB- cord-005453-4057qib7 593 18 regimen regimen NN cord-005453-4057qib7 593 19 as as IN cord-005453-4057qib7 593 20 salvage salvage NN cord-005453-4057qib7 593 21 therapy therapy NN cord-005453-4057qib7 593 22 . . . cord-005453-4057qib7 594 1 Donors donor NNS cord-005453-4057qib7 594 2 were be VBD cord-005453-4057qib7 594 3 haploidentical haploidentical JJ cord-005453-4057qib7 594 4 relatives relative NNS cord-005453-4057qib7 594 5 for for IN cord-005453-4057qib7 594 6 15/27 15/27 CD cord-005453-4057qib7 594 7 ( ( -LRB- cord-005453-4057qib7 594 8 56 56 CD cord-005453-4057qib7 594 9 % % NN cord-005453-4057qib7 594 10 ) ) -RRB- cord-005453-4057qib7 594 11 patients patient NNS cord-005453-4057qib7 594 12 , , , cord-005453-4057qib7 594 13 identical identical JJ cord-005453-4057qib7 594 14 siblings sibling NNS cord-005453-4057qib7 594 15 and and CC cord-005453-4057qib7 594 16 matched match VBN cord-005453-4057qib7 594 17 - - HYPH cord-005453-4057qib7 594 18 unrelated unrelated JJ cord-005453-4057qib7 594 19 for for IN cord-005453-4057qib7 594 20 6/27 6/27 CD cord-005453-4057qib7 594 21 patients patient NNS cord-005453-4057qib7 594 22 ( ( -LRB- cord-005453-4057qib7 594 23 22 22 CD cord-005453-4057qib7 594 24 % % NN cord-005453-4057qib7 594 25 ) ) -RRB- cord-005453-4057qib7 594 26 and and CC cord-005453-4057qib7 594 27 6/27 6/27 CD cord-005453-4057qib7 594 28 ( ( -LRB- cord-005453-4057qib7 594 29 22 22 CD cord-005453-4057qib7 594 30 % % NN cord-005453-4057qib7 594 31 ) ) -RRB- cord-005453-4057qib7 594 32 , , , cord-005453-4057qib7 594 33 respectively respectively RB cord-005453-4057qib7 594 34 . . . cord-005453-4057qib7 595 1 A a DT cord-005453-4057qib7 595 2 myeloablative myeloablative JJ cord-005453-4057qib7 595 3 conditioning conditioning NN cord-005453-4057qib7 595 4 was be VBD cord-005453-4057qib7 595 5 used use VBN cord-005453-4057qib7 595 6 to to TO cord-005453-4057qib7 595 7 further further RB cord-005453-4057qib7 595 8 implement implement VB cord-005453-4057qib7 595 9 anti anti JJ cord-005453-4057qib7 595 10 - - JJ cord-005453-4057qib7 595 11 leukemic leukemic JJ cord-005453-4057qib7 595 12 effects effect NNS cord-005453-4057qib7 595 13 . . . cord-005453-4057qib7 596 1 Conditioning conditioning NN cord-005453-4057qib7 596 2 , , , cord-005453-4057qib7 596 3 Thiotepa Thiotepa NNP cord-005453-4057qib7 596 4 - - HYPH cord-005453-4057qib7 596 5 Busulfan Busulfan NNP cord-005453-4057qib7 596 6 - - HYPH cord-005453-4057qib7 596 7 Fludarabine Fludarabine NNP cord-005453-4057qib7 596 8 in in IN cord-005453-4057qib7 596 9 89 89 CD cord-005453-4057qib7 596 10 % % NN cord-005453-4057qib7 596 11 patients patient NNS cord-005453-4057qib7 596 12 , , , cord-005453-4057qib7 596 13 was be VBD cord-005453-4057qib7 596 14 started start VBN cord-005453-4057qib7 596 15 at at IN cord-005453-4057qib7 596 16 a a DT cord-005453-4057qib7 596 17 median median NN cord-005453-4057qib7 596 18 of of IN cord-005453-4057qib7 596 19 8 8 CD cord-005453-4057qib7 596 20 days day NNS cord-005453-4057qib7 596 21 ( ( -LRB- cord-005453-4057qib7 596 22 range range VBP cord-005453-4057qib7 596 23 [ [ -LRB- cord-005453-4057qib7 596 24 3 3 CD cord-005453-4057qib7 596 25 ] ] -RRB- cord-005453-4057qib7 596 26 [ [ -LRB- cord-005453-4057qib7 596 27 4 4 CD cord-005453-4057qib7 596 28 ] ] -RRB- cord-005453-4057qib7 596 29 [ [ -LRB- cord-005453-4057qib7 596 30 5 5 CD cord-005453-4057qib7 596 31 ] ] -RRB- cord-005453-4057qib7 596 32 [ [ -LRB- cord-005453-4057qib7 596 33 6 6 CD cord-005453-4057qib7 596 34 ] ] -RRB- cord-005453-4057qib7 596 35 [ [ -LRB- cord-005453-4057qib7 596 36 7 7 CD cord-005453-4057qib7 596 37 ] ] -RRB- cord-005453-4057qib7 596 38 [ [ -LRB- cord-005453-4057qib7 596 39 8 8 CD cord-005453-4057qib7 596 40 ] ] -RRB- cord-005453-4057qib7 596 41 [ [ -LRB- cord-005453-4057qib7 596 42 9 9 CD cord-005453-4057qib7 596 43 ] ] -RRB- cord-005453-4057qib7 596 44 [ [ -LRB- cord-005453-4057qib7 596 45 10 10 CD cord-005453-4057qib7 596 46 ] ] -RRB- cord-005453-4057qib7 596 47 [ [ -LRB- cord-005453-4057qib7 596 48 11 11 CD cord-005453-4057qib7 596 49 ] ] -RRB- cord-005453-4057qib7 596 50 [ [ -LRB- cord-005453-4057qib7 596 51 12 12 CD cord-005453-4057qib7 596 52 ] ] -RRB- cord-005453-4057qib7 596 53 [ [ -LRB- cord-005453-4057qib7 596 54 13 13 CD cord-005453-4057qib7 596 55 ] ] -RRB- cord-005453-4057qib7 597 1 [ [ -LRB- cord-005453-4057qib7 597 2 14 14 CD cord-005453-4057qib7 597 3 ] ] -RRB- cord-005453-4057qib7 597 4 after after IN cord-005453-4057qib7 597 5 the the DT cord-005453-4057qib7 597 6 last last JJ cord-005453-4057qib7 597 7 day day NN cord-005453-4057qib7 597 8 of of IN cord-005453-4057qib7 597 9 chemotherapy chemotherapy NN cord-005453-4057qib7 597 10 . . . cord-005453-4057qib7 598 1 Bone bone NN cord-005453-4057qib7 598 2 marrow marrow NN cord-005453-4057qib7 598 3 and and CC cord-005453-4057qib7 598 4 peripheral peripheral JJ cord-005453-4057qib7 598 5 blood blood NN cord-005453-4057qib7 598 6 stem stem NN cord-005453-4057qib7 598 7 cells cell NNS cord-005453-4057qib7 598 8 were be VBD cord-005453-4057qib7 598 9 used use VBN cord-005453-4057qib7 598 10 as as IN cord-005453-4057qib7 598 11 graft graft NN cord-005453-4057qib7 598 12 source source NN cord-005453-4057qib7 598 13 in in IN cord-005453-4057qib7 598 14 11/27 11/27 CD cord-005453-4057qib7 598 15 ( ( -LRB- cord-005453-4057qib7 598 16 41 41 CD cord-005453-4057qib7 598 17 % % NN cord-005453-4057qib7 598 18 ) ) -RRB- cord-005453-4057qib7 598 19 and and CC cord-005453-4057qib7 598 20 16/27 16/27 CD cord-005453-4057qib7 598 21 ( ( -LRB- cord-005453-4057qib7 598 22 59 59 CD cord-005453-4057qib7 598 23 % % NN cord-005453-4057qib7 598 24 ) ) -RRB- cord-005453-4057qib7 598 25 patients patient NNS cord-005453-4057qib7 598 26 . . . cord-005453-4057qib7 599 1 Graft graft NN cord-005453-4057qib7 599 2 - - HYPH cord-005453-4057qib7 599 3 versus versus IN cord-005453-4057qib7 599 4 - - HYPH cord-005453-4057qib7 599 5 host host NN cord-005453-4057qib7 599 6 disease disease NN cord-005453-4057qib7 599 7 ( ( -LRB- cord-005453-4057qib7 599 8 GVHD GVHD NNP cord-005453-4057qib7 599 9 ) ) -RRB- cord-005453-4057qib7 599 10 prophylaxis prophylaxis NN cord-005453-4057qib7 599 11 and and CC cord-005453-4057qib7 599 12 supportive supportive JJ cord-005453-4057qib7 599 13 care care NN cord-005453-4057qib7 599 14 were be VBD cord-005453-4057qib7 599 15 administered administer VBN cord-005453-4057qib7 599 16 accordingly accordingly RB cord-005453-4057qib7 599 17 to to IN cord-005453-4057qib7 599 18 each each DT cord-005453-4057qib7 599 19 HSCT HSCT NNP cord-005453-4057qib7 599 20 platform platform NN cord-005453-4057qib7 599 21 . . . cord-005453-4057qib7 600 1 Results result NNS cord-005453-4057qib7 600 2 : : : cord-005453-4057qib7 601 1 All all DT cord-005453-4057qib7 601 2 patients patient NNS cord-005453-4057qib7 601 3 engrafted engraft VBD cord-005453-4057qib7 601 4 . . . cord-005453-4057qib7 602 1 Median median JJ cord-005453-4057qib7 602 2 day day NN cord-005453-4057qib7 602 3 of of IN cord-005453-4057qib7 602 4 neutrophil neutrophil NN cord-005453-4057qib7 602 5 recovery recovery NN cord-005453-4057qib7 602 6 was be VBD cord-005453-4057qib7 602 7 day day NN cord-005453-4057qib7 602 8 +16 +16 CD cord-005453-4057qib7 603 1 ( ( -LRB- cord-005453-4057qib7 603 2 range range NNP cord-005453-4057qib7 603 3 12 12 CD cord-005453-4057qib7 603 4 - - SYM cord-005453-4057qib7 603 5 23 23 CD cord-005453-4057qib7 603 6 ) ) -RRB- cord-005453-4057qib7 603 7 . . . cord-005453-4057qib7 604 1 Median median JJ cord-005453-4057qib7 604 2 follow follow NN cord-005453-4057qib7 604 3 - - HYPH cord-005453-4057qib7 604 4 up up NN cord-005453-4057qib7 604 5 of of IN cord-005453-4057qib7 604 6 survivors survivor NNS cord-005453-4057qib7 604 7 was be VBD cord-005453-4057qib7 604 8 31 31 CD cord-005453-4057qib7 604 9 months month NNS cord-005453-4057qib7 605 1 ( ( -LRB- cord-005453-4057qib7 605 2 range range NNP cord-005453-4057qib7 605 3 4 4 CD cord-005453-4057qib7 605 4 - - SYM cord-005453-4057qib7 605 5 125 125 CD cord-005453-4057qib7 605 6 ) ) -RRB- cord-005453-4057qib7 605 7 . . . cord-005453-4057qib7 606 1 Non non JJ cord-005453-4057qib7 606 2 Relapse Relapse NNP cord-005453-4057qib7 606 3 Mortality mortality NN cord-005453-4057qib7 606 4 and and CC cord-005453-4057qib7 606 5 Relapse Relapse NNP cord-005453-4057qib7 606 6 Incidences Incidences NNPS cord-005453-4057qib7 606 7 ( ( -LRB- cord-005453-4057qib7 606 8 NRM NRM NNP cord-005453-4057qib7 606 9 , , , cord-005453-4057qib7 606 10 RI RI NNP cord-005453-4057qib7 606 11 ) ) -RRB- cord-005453-4057qib7 606 12 were be VBD cord-005453-4057qib7 606 13 16 16 CD cord-005453-4057qib7 606 14 % % NN cord-005453-4057qib7 606 15 and and CC cord-005453-4057qib7 606 16 48 48 CD cord-005453-4057qib7 606 17 % % NN cord-005453-4057qib7 606 18 at at IN cord-005453-4057qib7 606 19 1 1 CD cord-005453-4057qib7 606 20 year year NN cord-005453-4057qib7 606 21 and and CC cord-005453-4057qib7 606 22 16 16 CD cord-005453-4057qib7 606 23 % % NN cord-005453-4057qib7 606 24 and and CC cord-005453-4057qib7 606 25 58 58 CD cord-005453-4057qib7 606 26 % % NN cord-005453-4057qib7 606 27 at at IN cord-005453-4057qib7 606 28 3 3 CD cord-005453-4057qib7 606 29 years year NNS cord-005453-4057qib7 606 30 , , , cord-005453-4057qib7 606 31 respectively respectively RB cord-005453-4057qib7 606 32 . . . cord-005453-4057qib7 607 1 Overall overall JJ cord-005453-4057qib7 607 2 cumulative cumulative JJ cord-005453-4057qib7 607 3 incidences incidence NNS cord-005453-4057qib7 607 4 of of IN cord-005453-4057qib7 607 5 acute acute JJ cord-005453-4057qib7 607 6 and and CC cord-005453-4057qib7 607 7 chronic chronic JJ cord-005453-4057qib7 607 8 GVHD GVHD NNP cord-005453-4057qib7 607 9 were be VBD cord-005453-4057qib7 607 10 48 48 CD cord-005453-4057qib7 607 11 % % NN cord-005453-4057qib7 607 12 and and CC cord-005453-4057qib7 607 13 43 43 CD cord-005453-4057qib7 607 14 % % NN cord-005453-4057qib7 607 15 at at IN cord-005453-4057qib7 607 16 day day NN cord-005453-4057qib7 607 17 +100 +100 NNS cord-005453-4057qib7 607 18 and and CC cord-005453-4057qib7 607 19 + + SYM cord-005453-4057qib7 607 20 400 400 CD cord-005453-4057qib7 607 21 . . . cord-005453-4057qib7 608 1 One one CD cord-005453-4057qib7 608 2 and and CC cord-005453-4057qib7 608 3 3 3 CD cord-005453-4057qib7 608 4 year year NN cord-005453-4057qib7 609 1 Overall Overall NNP cord-005453-4057qib7 609 2 Survival Survival NNP cord-005453-4057qib7 609 3 ( ( -LRB- cord-005453-4057qib7 609 4 OS OS NNP cord-005453-4057qib7 609 5 ) ) -RRB- cord-005453-4057qib7 609 6 were be VBD cord-005453-4057qib7 609 7 58 58 CD cord-005453-4057qib7 609 8 % % NN cord-005453-4057qib7 609 9 and and CC cord-005453-4057qib7 609 10 34 34 CD cord-005453-4057qib7 609 11 % % NN cord-005453-4057qib7 609 12 , , , cord-005453-4057qib7 609 13 while while IN cord-005453-4057qib7 609 14 1 1 CD cord-005453-4057qib7 609 15 and and CC cord-005453-4057qib7 609 16 3 3 CD cord-005453-4057qib7 609 17 year year NN cord-005453-4057qib7 609 18 Event event NN cord-005453-4057qib7 609 19 - - HYPH cord-005453-4057qib7 609 20 Free Free NNP cord-005453-4057qib7 609 21 Survival Survival NNP cord-005453-4057qib7 609 22 ( ( -LRB- cord-005453-4057qib7 609 23 EFS EFS NNP cord-005453-4057qib7 609 24 ) ) -RRB- cord-005453-4057qib7 609 25 were be VBD cord-005453-4057qib7 609 26 35 35 CD cord-005453-4057qib7 609 27 % % NN cord-005453-4057qib7 609 28 and and CC cord-005453-4057qib7 609 29 26 26 CD cord-005453-4057qib7 609 30 % % NN cord-005453-4057qib7 609 31 . . . cord-005453-4057qib7 610 1 Significant significant JJ cord-005453-4057qib7 610 2 better well JJR cord-005453-4057qib7 610 3 OS OS NNP cord-005453-4057qib7 610 4 and and CC cord-005453-4057qib7 610 5 EFS EFS NNP cord-005453-4057qib7 610 6 were be VBD cord-005453-4057qib7 610 7 observed observe VBN cord-005453-4057qib7 610 8 in in IN cord-005453-4057qib7 610 9 patients patient NNS cord-005453-4057qib7 610 10 with with IN cord-005453-4057qib7 610 11 Favorable favorable JJ cord-005453-4057qib7 610 12 - - HYPH cord-005453-4057qib7 610 13 Intermediate Intermediate NNP cord-005453-4057qib7 610 14 I I NNP cord-005453-4057qib7 610 15 - - HYPH cord-005453-4057qib7 610 16 II II NNP cord-005453-4057qib7 610 17 versus versus IN cord-005453-4057qib7 610 18 Adverse adverse JJ cord-005453-4057qib7 610 19 risk risk NN cord-005453-4057qib7 610 20 score score NN cord-005453-4057qib7 610 21 ( ( -LRB- cord-005453-4057qib7 610 22 1 1 CD cord-005453-4057qib7 610 23 - - SYM cord-005453-4057qib7 610 24 3 3 CD cord-005453-4057qib7 610 25 years year NNS cord-005453-4057qib7 610 26 OS OS NNP cord-005453-4057qib7 610 27 64 64 CD cord-005453-4057qib7 610 28 % % NN cord-005453-4057qib7 610 29 and and CC cord-005453-4057qib7 610 30 50 50 CD cord-005453-4057qib7 610 31 % % NN cord-005453-4057qib7 610 32 vs vs IN cord-005453-4057qib7 610 33 43 43 CD cord-005453-4057qib7 610 34 % % NN cord-005453-4057qib7 610 35 and and CC cord-005453-4057qib7 610 36 0 0 CD cord-005453-4057qib7 610 37 % % NN cord-005453-4057qib7 610 38 p=0.022 p=0.022 NN cord-005453-4057qib7 610 39 ; ; : cord-005453-4057qib7 610 40 1 1 CD cord-005453-4057qib7 610 41 - - SYM cord-005453-4057qib7 610 42 3 3 CD cord-005453-4057qib7 610 43 years year NNS cord-005453-4057qib7 610 44 EFS EFS NNP cord-005453-4057qib7 610 45 43 43 CD cord-005453-4057qib7 610 46 % % NN cord-005453-4057qib7 610 47 and and CC cord-005453-4057qib7 610 48 36 36 CD cord-005453-4057qib7 610 49 % % NN cord-005453-4057qib7 610 50 vs vs IN cord-005453-4057qib7 610 51 14 14 CD cord-005453-4057qib7 610 52 % % NN cord-005453-4057qib7 610 53 and and CC cord-005453-4057qib7 610 54 0 0 CD cord-005453-4057qib7 610 55 % % NN cord-005453-4057qib7 610 56 p=0.013 p=0.013 NN cord-005453-4057qib7 610 57 ) ) -RRB- cord-005453-4057qib7 610 58 . . . cord-005453-4057qib7 611 1 Adverse adverse JJ cord-005453-4057qib7 611 2 risk risk NN cord-005453-4057qib7 611 3 had have VBD cord-005453-4057qib7 611 4 a a DT cord-005453-4057qib7 611 5 significant significant JJ cord-005453-4057qib7 611 6 impact impact NN cord-005453-4057qib7 611 7 on on IN cord-005453-4057qib7 611 8 OS OS NNP cord-005453-4057qib7 611 9 ( ( -LRB- cord-005453-4057qib7 611 10 HR HR NNP cord-005453-4057qib7 611 11 3.24 3.24 CD cord-005453-4057qib7 611 12 , , , cord-005453-4057qib7 611 13 p=0.030 p=0.030 NNP cord-005453-4057qib7 611 14 ) ) -RRB- cord-005453-4057qib7 611 15 and and CC cord-005453-4057qib7 611 16 EFS EFS NNP cord-005453-4057qib7 611 17 ( ( -LRB- cord-005453-4057qib7 611 18 HR HR NNP cord-005453-4057qib7 611 19 3.33 3.33 CD cord-005453-4057qib7 611 20 , , , cord-005453-4057qib7 611 21 p=0 p=0 NNP cord-005453-4057qib7 611 22 .018 .018 CD cord-005453-4057qib7 611 23 ) ) -RRB- cord-005453-4057qib7 611 24 by by IN cord-005453-4057qib7 611 25 univariate univariate JJ cord-005453-4057qib7 611 26 analysis analysis NN cord-005453-4057qib7 611 27 and and CC cord-005453-4057qib7 611 28 on on IN cord-005453-4057qib7 611 29 RI RI NNP cord-005453-4057qib7 611 30 ( ( -LRB- cord-005453-4057qib7 611 31 SDHR SDHR NNP cord-005453-4057qib7 611 32 3.02 3.02 CD cord-005453-4057qib7 611 33 , , , cord-005453-4057qib7 611 34 p=0.031 p=0.031 NNP cord-005453-4057qib7 611 35 ) ) -RRB- cord-005453-4057qib7 611 36 by by IN cord-005453-4057qib7 611 37 Fine Fine NNP cord-005453-4057qib7 611 38 and and CC cord-005453-4057qib7 611 39 Gray Gray NNP cord-005453-4057qib7 611 40 Test Test NNP cord-005453-4057qib7 611 41 . . . cord-005453-4057qib7 612 1 Conclusions conclusion NNS cord-005453-4057qib7 612 2 : : : cord-005453-4057qib7 613 1 Though though IN cord-005453-4057qib7 613 2 small small JJ cord-005453-4057qib7 613 3 the the DT cord-005453-4057qib7 613 4 patient patient JJ cord-005453-4057qib7 613 5 cohort cohort NN cord-005453-4057qib7 613 6 , , , cord-005453-4057qib7 613 7 our -PRON- PRP$ cord-005453-4057qib7 613 8 findings finding NNS cord-005453-4057qib7 613 9 suggest suggest VBP cord-005453-4057qib7 613 10 that that IN cord-005453-4057qib7 613 11 sequential sequential JJ cord-005453-4057qib7 613 12 therapy therapy NN cord-005453-4057qib7 613 13 with with IN cord-005453-4057qib7 613 14 a a DT cord-005453-4057qib7 613 15 myeloablative myeloablative JJ cord-005453-4057qib7 613 16 HSCT HSCT NNP cord-005453-4057qib7 613 17 is be VBZ cord-005453-4057qib7 613 18 feasible feasible JJ cord-005453-4057qib7 613 19 in in IN cord-005453-4057qib7 613 20 treating treat VBG cord-005453-4057qib7 613 21 relapsed relapse VBN cord-005453-4057qib7 613 22 / / SYM cord-005453-4057qib7 613 23 refractory refractory JJ cord-005453-4057qib7 613 24 AML AML NNP cord-005453-4057qib7 613 25 . . . cord-005453-4057qib7 614 1 Transplant transplant NN cord-005453-4057qib7 614 2 - - HYPH cord-005453-4057qib7 614 3 related relate VBN cord-005453-4057qib7 614 4 toxicity toxicity NN cord-005453-4057qib7 614 5 was be VBD cord-005453-4057qib7 614 6 low low JJ cord-005453-4057qib7 614 7 ( ( -LRB- cord-005453-4057qib7 614 8 16 16 CD cord-005453-4057qib7 614 9 % % NN cord-005453-4057qib7 614 10 ) ) -RRB- cord-005453-4057qib7 614 11 and and CC cord-005453-4057qib7 614 12 relapse relapse NN cord-005453-4057qib7 614 13 was be VBD cord-005453-4057qib7 614 14 the the DT cord-005453-4057qib7 614 15 major major JJ cord-005453-4057qib7 614 16 treatment treatment NN cord-005453-4057qib7 614 17 - - HYPH cord-005453-4057qib7 614 18 failure failure NN cord-005453-4057qib7 614 19 . . . cord-005453-4057qib7 615 1 However however RB cord-005453-4057qib7 615 2 , , , cord-005453-4057qib7 615 3 even even RB cord-005453-4057qib7 615 4 with with IN cord-005453-4057qib7 615 5 this this DT cord-005453-4057qib7 615 6 approach approach NN cord-005453-4057qib7 615 7 , , , cord-005453-4057qib7 615 8 patients patient NNS cord-005453-4057qib7 615 9 with with IN cord-005453-4057qib7 615 10 adverse adverse JJ cord-005453-4057qib7 615 11 cytogenetic cytogenetic JJ cord-005453-4057qib7 615 12 features feature NNS cord-005453-4057qib7 615 13 have have VBP cord-005453-4057qib7 615 14 a a DT cord-005453-4057qib7 615 15 very very RB cord-005453-4057qib7 615 16 dismal dismal JJ cord-005453-4057qib7 615 17 prognosis prognosis NN cord-005453-4057qib7 615 18 . . . cord-005453-4057qib7 616 1 For for IN cord-005453-4057qib7 616 2 these these DT cord-005453-4057qib7 616 3 patients patient NNS cord-005453-4057qib7 616 4 , , , cord-005453-4057qib7 616 5 the the DT cord-005453-4057qib7 616 6 use use NN cord-005453-4057qib7 616 7 of of IN cord-005453-4057qib7 616 8 new new JJ cord-005453-4057qib7 616 9 drugs drug NNS cord-005453-4057qib7 616 10 before before IN cord-005453-4057qib7 616 11 HSCT HSCT NNP cord-005453-4057qib7 616 12 and/or and/or CC cord-005453-4057qib7 616 13 maintenance maintenance NN cord-005453-4057qib7 616 14 therapy therapy NN cord-005453-4057qib7 616 15 after after IN cord-005453-4057qib7 616 16 transplant transplant NN cord-005453-4057qib7 616 17 is be VBZ cord-005453-4057qib7 616 18 highly highly RB cord-005453-4057qib7 616 19 encouraged encouraged JJ cord-005453-4057qib7 616 20 to to TO cord-005453-4057qib7 616 21 improve improve VB cord-005453-4057qib7 616 22 outcomes outcome NNS cord-005453-4057qib7 616 23 . . . cord-005453-4057qib7 617 1 Disclosure disclosure NN cord-005453-4057qib7 617 2 : : : cord-005453-4057qib7 617 3 Alessandro Alessandro NNP cord-005453-4057qib7 617 4 Busca Busca NNP cord-005453-4057qib7 617 5 : : : cord-005453-4057qib7 617 6 Honoraria Honoraria NNP cord-005453-4057qib7 617 7 from from IN cord-005453-4057qib7 617 8 Gilead Gilead NNP cord-005453-4057qib7 617 9 Sciences Sciences NNPS cord-005453-4057qib7 617 10 , , , cord-005453-4057qib7 617 11 Merck Merck NNP cord-005453-4057qib7 617 12 , , , cord-005453-4057qib7 617 13 Pfizer Pfizer NNP cord-005453-4057qib7 617 14 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 617 15 and and CC cord-005453-4057qib7 617 16 Jazz Jazz NNP cord-005453-4057qib7 617 17 Background background NN cord-005453-4057qib7 617 18 : : : cord-005453-4057qib7 618 1 In in IN cord-005453-4057qib7 618 2 spite spite NN cord-005453-4057qib7 618 3 of of IN cord-005453-4057qib7 618 4 satisfactory satisfactory JJ cord-005453-4057qib7 618 5 results result NNS cord-005453-4057qib7 618 6 of of IN cord-005453-4057qib7 618 7 overall overall JJ cord-005453-4057qib7 618 8 survival survival NN cord-005453-4057qib7 618 9 ( ( -LRB- cord-005453-4057qib7 618 10 OS OS NNP cord-005453-4057qib7 618 11 ) ) -RRB- cord-005453-4057qib7 618 12 after after IN cord-005453-4057qib7 618 13 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 618 14 in in IN cord-005453-4057qib7 618 15 1 1 CD cord-005453-4057qib7 618 16 st st NNP cord-005453-4057qib7 618 17 and and CC cord-005453-4057qib7 618 18 2 2 CD cord-005453-4057qib7 618 19 nd nd NNP cord-005453-4057qib7 618 20 CR CR NNP cord-005453-4057qib7 618 21 AML AML NNP cord-005453-4057qib7 618 22 , , , cord-005453-4057qib7 618 23 relapse relapse VB cord-005453-4057qib7 618 24 free free JJ cord-005453-4057qib7 618 25 survival survival NN cord-005453-4057qib7 618 26 ( ( -LRB- cord-005453-4057qib7 618 27 RFS RFS NNP cord-005453-4057qib7 618 28 ) ) -RRB- cord-005453-4057qib7 618 29 and and CC cord-005453-4057qib7 618 30 graft graft NN cord-005453-4057qib7 618 31 - - HYPH cord-005453-4057qib7 618 32 versus versus IN cord-005453-4057qib7 618 33 - - HYPH cord-005453-4057qib7 618 34 host host NN cord-005453-4057qib7 618 35 - - HYPH cord-005453-4057qib7 618 36 disease disease NN cord-005453-4057qib7 618 37 free free JJ cord-005453-4057qib7 618 38 / / NFP cord-005453-4057qib7 618 39 relapse relapse VB cord-005453-4057qib7 618 40 free free JJ cord-005453-4057qib7 618 41 survival survival NN cord-005453-4057qib7 618 42 ( ( -LRB- cord-005453-4057qib7 618 43 GRFS GRFS NNP cord-005453-4057qib7 618 44 ) ) -RRB- cord-005453-4057qib7 618 45 require require VBP cord-005453-4057qib7 618 46 further further JJ cord-005453-4057qib7 618 47 improvement improvement NN cord-005453-4057qib7 618 48 . . . cord-005453-4057qib7 619 1 The the DT cord-005453-4057qib7 619 2 detection detection NN cord-005453-4057qib7 619 3 of of IN cord-005453-4057qib7 619 4 MRD MRD NNP cord-005453-4057qib7 619 5 is be VBZ cord-005453-4057qib7 619 6 one one CD cord-005453-4057qib7 619 7 of of IN cord-005453-4057qib7 619 8 the the DT cord-005453-4057qib7 619 9 factors factor NNS cord-005453-4057qib7 619 10 which which WDT cord-005453-4057qib7 619 11 influence influence VBP cord-005453-4057qib7 619 12 on on IN cord-005453-4057qib7 619 13 the the DT cord-005453-4057qib7 619 14 outcome outcome NN cord-005453-4057qib7 619 15 of of IN cord-005453-4057qib7 619 16 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 619 17 in in IN cord-005453-4057qib7 619 18 AML AML NNP cord-005453-4057qib7 619 19 is be VBZ cord-005453-4057qib7 619 20 unclear unclear JJ cord-005453-4057qib7 619 21 but but CC cord-005453-4057qib7 619 22 identification identification NN cord-005453-4057qib7 619 23 is be VBZ cord-005453-4057qib7 619 24 important important JJ cord-005453-4057qib7 619 25 to to TO cord-005453-4057qib7 619 26 improve improve VB cord-005453-4057qib7 619 27 risk risk NN cord-005453-4057qib7 619 28 - - HYPH cord-005453-4057qib7 619 29 adapted adapt VBN cord-005453-4057qib7 619 30 relapse relapse NN cord-005453-4057qib7 619 31 prophylactic prophylactic JJ cord-005453-4057qib7 619 32 treatment treatment NN cord-005453-4057qib7 619 33 after after IN cord-005453-4057qib7 619 34 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 619 35 . . . cord-005453-4057qib7 620 1 Aim aim VB cord-005453-4057qib7 620 2 . . . cord-005453-4057qib7 621 1 To to TO cord-005453-4057qib7 621 2 evaluate evaluate VB cord-005453-4057qib7 621 3 outcomes outcome NNS cord-005453-4057qib7 621 4 of of IN cord-005453-4057qib7 621 5 AlloHCST AlloHCST NNP cord-005453-4057qib7 621 6 in in IN cord-005453-4057qib7 621 7 1 1 CD cord-005453-4057qib7 621 8 st st NNP cord-005453-4057qib7 621 9 and and CC cord-005453-4057qib7 621 10 2 2 CD cord-005453-4057qib7 621 11 nd nd NNP cord-005453-4057qib7 621 12 CR CR NNP cord-005453-4057qib7 621 13 pediatric pediatric JJ cord-005453-4057qib7 621 14 AML AML NNP cord-005453-4057qib7 621 15 depending depend VBG cord-005453-4057qib7 621 16 on on IN cord-005453-4057qib7 621 17 the the DT cord-005453-4057qib7 621 18 level level NN cord-005453-4057qib7 621 19 of of IN cord-005453-4057qib7 621 20 MRD MRD NNP cord-005453-4057qib7 621 21 status status NN cord-005453-4057qib7 621 22 before before IN cord-005453-4057qib7 621 23 myeloablative myeloablative NNP cord-005453-4057qib7 621 24 ( ( -LRB- cord-005453-4057qib7 621 25 MAC MAC NNP cord-005453-4057qib7 621 26 ) ) -RRB- cord-005453-4057qib7 621 27 or or CC cord-005453-4057qib7 621 28 reduced reduce VBN cord-005453-4057qib7 621 29 intensity intensity NN cord-005453-4057qib7 621 30 conditioning conditioning NN cord-005453-4057qib7 621 31 regimens regimen NNS cord-005453-4057qib7 621 32 ( ( -LRB- cord-005453-4057qib7 621 33 RIC RIC NNP cord-005453-4057qib7 621 34 ) ) -RRB- cord-005453-4057qib7 621 35 . . . cord-005453-4057qib7 622 1 Methods method NNS cord-005453-4057qib7 622 2 : : : cord-005453-4057qib7 623 1 The the DT cord-005453-4057qib7 623 2 data datum NNS cord-005453-4057qib7 623 3 of of IN cord-005453-4057qib7 623 4 72 72 CD cord-005453-4057qib7 623 5 children child NNS cord-005453-4057qib7 623 6 with with IN cord-005453-4057qib7 623 7 AML AML NNP cord-005453-4057qib7 623 8 in in IN cord-005453-4057qib7 623 9 1 1 CD cord-005453-4057qib7 623 10 st st NNP cord-005453-4057qib7 623 11 and and CC cord-005453-4057qib7 623 12 2 2 CD cord-005453-4057qib7 623 13 nd nd NNP cord-005453-4057qib7 623 14 CR CR NNP cord-005453-4057qib7 623 15 underwent undergo VBD cord-005453-4057qib7 623 16 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 623 17 between between IN cord-005453-4057qib7 623 18 2008 2008 CD cord-005453-4057qib7 623 19 and and CC cord-005453-4057qib7 623 20 2018 2018 CD cord-005453-4057qib7 623 21 were be VBD cord-005453-4057qib7 623 22 analyzed analyze VBN cord-005453-4057qib7 623 23 . . . cord-005453-4057qib7 624 1 Median median JJ cord-005453-4057qib7 624 2 age age NN cord-005453-4057qib7 624 3 at at IN cord-005453-4057qib7 624 4 the the DT cord-005453-4057qib7 624 5 moment moment NN cord-005453-4057qib7 624 6 of of IN cord-005453-4057qib7 624 7 AlloHCST AlloHCST NNP cord-005453-4057qib7 624 8 was be VBD cord-005453-4057qib7 624 9 8 8 CD cord-005453-4057qib7 624 10 years year NNS cord-005453-4057qib7 624 11 old old JJ cord-005453-4057qib7 624 12 ( ( -LRB- cord-005453-4057qib7 624 13 2 2 CD cord-005453-4057qib7 624 14 - - SYM cord-005453-4057qib7 624 15 18 18 CD cord-005453-4057qib7 624 16 ) ) -RRB- cord-005453-4057qib7 624 17 . . . cord-005453-4057qib7 625 1 MRD MRD NNP cord-005453-4057qib7 625 2 negative negative JJ cord-005453-4057qib7 625 3 status status NN cord-005453-4057qib7 625 4 had have VBD cord-005453-4057qib7 625 5 42 42 CD cord-005453-4057qib7 625 6 ( ( -LRB- cord-005453-4057qib7 625 7 58 58 CD cord-005453-4057qib7 625 8 % % NN cord-005453-4057qib7 625 9 ) ) -RRB- cord-005453-4057qib7 625 10 patients patient NNS cord-005453-4057qib7 625 11 , , , cord-005453-4057qib7 625 12 30 30 CD cord-005453-4057qib7 625 13 ( ( -LRB- cord-005453-4057qib7 625 14 42 42 CD cord-005453-4057qib7 625 15 % % NN cord-005453-4057qib7 625 16 ) ) -RRB- cord-005453-4057qib7 625 17 were be VBD cord-005453-4057qib7 625 18 MRD MRD NNP cord-005453-4057qib7 625 19 positive positive JJ cord-005453-4057qib7 625 20 by by IN cord-005453-4057qib7 625 21 flow flow NN cord-005453-4057qib7 625 22 cytometry cytometry NN cord-005453-4057qib7 625 23 . . . cord-005453-4057qib7 626 1 MAC MAC NNP cord-005453-4057qib7 626 2 based base VBN cord-005453-4057qib7 626 3 on on IN cord-005453-4057qib7 626 4 busulfan busulfan NN cord-005453-4057qib7 626 5 ( ( -LRB- cord-005453-4057qib7 626 6 16 16 CD cord-005453-4057qib7 626 7 mg mg NNP cord-005453-4057qib7 626 8 / / SYM cord-005453-4057qib7 626 9 b.w b.w NNP cord-005453-4057qib7 626 10 . . NNP cord-005453-4057qib7 626 11 ) ) -RRB- cord-005453-4057qib7 626 12 received receive VBD cord-005453-4057qib7 626 13 27 27 CD cord-005453-4057qib7 626 14 ( ( -LRB- cord-005453-4057qib7 626 15 37 37 CD cord-005453-4057qib7 626 16 % % NN cord-005453-4057qib7 626 17 ) ) -RRB- cord-005453-4057qib7 626 18 patients patient NNS cord-005453-4057qib7 626 19 , , , cord-005453-4057qib7 626 20 on on IN cord-005453-4057qib7 626 21 treosulfan treosulfan NNP cord-005453-4057qib7 626 22 -7 -7 . cord-005453-4057qib7 627 1 ( ( -LRB- cord-005453-4057qib7 627 2 10 10 CD cord-005453-4057qib7 627 3 % % NN cord-005453-4057qib7 627 4 ) ) -RRB- cord-005453-4057qib7 627 5 patients patient NNS cord-005453-4057qib7 627 6 . . . cord-005453-4057qib7 628 1 RIC RIC NNP cord-005453-4057qib7 628 2 based base VBN cord-005453-4057qib7 628 3 on on IN cord-005453-4057qib7 628 4 melphalan melphalan NNP cord-005453-4057qib7 628 5 received receive VBD cord-005453-4057qib7 628 6 20 20 CD cord-005453-4057qib7 628 7 ( ( -LRB- cord-005453-4057qib7 628 8 28 28 CD cord-005453-4057qib7 628 9 % % NN cord-005453-4057qib7 628 10 ) ) -RRB- cord-005453-4057qib7 628 11 patients patient NNS cord-005453-4057qib7 628 12 , , , cord-005453-4057qib7 628 13 based base VBN cord-005453-4057qib7 628 14 on on IN cord-005453-4057qib7 628 15 busulfan busulfan NN cord-005453-4057qib7 628 16 ( ( -LRB- cord-005453-4057qib7 628 17 8 8 CD cord-005453-4057qib7 628 18 mg mg NNP cord-005453-4057qib7 628 19 / / SYM cord-005453-4057qib7 628 20 b.w b.w NNP cord-005453-4057qib7 628 21 . . NNP cord-005453-4057qib7 628 22 ) ) -RRB- cord-005453-4057qib7 628 23 -18 -18 CD cord-005453-4057qib7 628 24 ( ( -LRB- cord-005453-4057qib7 628 25 25 25 CD cord-005453-4057qib7 628 26 % % NN cord-005453-4057qib7 628 27 ) ) -RRB- cord-005453-4057qib7 628 28 patients patient NNS cord-005453-4057qib7 628 29 . . . cord-005453-4057qib7 629 1 Patients patient NNS cord-005453-4057qib7 629 2 received receive VBD cord-005453-4057qib7 629 3 prophylaxis prophylaxis NN cord-005453-4057qib7 629 4 of of IN cord-005453-4057qib7 629 5 aGVHD aGVHD NNP cord-005453-4057qib7 629 6 by by IN cord-005453-4057qib7 629 7 ATG ATG NNP cord-005453-4057qib7 629 8 20 20 CD cord-005453-4057qib7 629 9 ( ( -LRB- cord-005453-4057qib7 629 10 28 28 CD cord-005453-4057qib7 629 11 % % NN cord-005453-4057qib7 629 12 ) ) -RRB- cord-005453-4057qib7 629 13 or or CC cord-005453-4057qib7 629 14 PTCy PTCy NNS cord-005453-4057qib7 629 15 -48 -48 NNP cord-005453-4057qib7 629 16 ( ( -LRB- cord-005453-4057qib7 629 17 66 66 CD cord-005453-4057qib7 629 18 % % NN cord-005453-4057qib7 629 19 ) ) -RRB- cord-005453-4057qib7 629 20 patients patient NNS cord-005453-4057qib7 629 21 plus plus CC cord-005453-4057qib7 629 22 CsA CsA NNP cord-005453-4057qib7 629 23 -23 -23 NN cord-005453-4057qib7 629 24 ( ( -LRB- cord-005453-4057qib7 629 25 32 32 CD cord-005453-4057qib7 629 26 % % NN cord-005453-4057qib7 629 27 ) ) -RRB- cord-005453-4057qib7 629 28 or or CC cord-005453-4057qib7 629 29 tacrolimus tacrolimus NNP cord-005453-4057qib7 629 30 ± ± NNP cord-005453-4057qib7 629 31 sirolimus sirolimus NNP cord-005453-4057qib7 629 32 -43 -43 NNP cord-005453-4057qib7 629 33 ( ( -LRB- cord-005453-4057qib7 629 34 60 60 CD cord-005453-4057qib7 629 35 % % NN cord-005453-4057qib7 629 36 ) ) -RRB- cord-005453-4057qib7 629 37 patients patient NNS cord-005453-4057qib7 629 38 that that WDT cord-005453-4057qib7 629 39 depended depend VBD cord-005453-4057qib7 629 40 on on IN cord-005453-4057qib7 629 41 source source NN cord-005453-4057qib7 629 42 of of IN cord-005453-4057qib7 629 43 transplant transplant NN cord-005453-4057qib7 629 44 ( ( -LRB- cord-005453-4057qib7 629 45 related relate VBN cord-005453-4057qib7 629 46 , , , cord-005453-4057qib7 629 47 unrelated unrelated JJ cord-005453-4057qib7 629 48 or or CC cord-005453-4057qib7 629 49 haplo haplo NN cord-005453-4057qib7 629 50 donor donor NN cord-005453-4057qib7 629 51 ) ) -RRB- cord-005453-4057qib7 629 52 . . . cord-005453-4057qib7 630 1 Results result NNS cord-005453-4057qib7 630 2 : : : cord-005453-4057qib7 631 1 At at IN cord-005453-4057qib7 631 2 the the DT cord-005453-4057qib7 631 3 median median NN cord-005453-4057qib7 631 4 follow follow VBP cord-005453-4057qib7 631 5 up up RB cord-005453-4057qib7 631 6 3 3 CD cord-005453-4057qib7 631 7 years year NNS cord-005453-4057qib7 631 8 in in IN cord-005453-4057qib7 631 9 the the DT cord-005453-4057qib7 631 10 cohort cohort NN cord-005453-4057qib7 631 11 of of IN cord-005453-4057qib7 631 12 MRD MRD NNP cord-005453-4057qib7 631 13 positive positive JJ cord-005453-4057qib7 631 14 patients patient NNS cord-005453-4057qib7 632 1 OS OS NNP cord-005453-4057qib7 632 2 is be VBZ cord-005453-4057qib7 632 3 66 66 CD cord-005453-4057qib7 632 4 % % NN cord-005453-4057qib7 632 5 vs vs IN cord-005453-4057qib7 632 6 72 72 CD cord-005453-4057qib7 632 7 % % NN cord-005453-4057qib7 632 8 in in IN cord-005453-4057qib7 632 9 MRD MRD NNP cord-005453-4057qib7 632 10 negative negative JJ cord-005453-4057qib7 632 11 ( ( -LRB- cord-005453-4057qib7 632 12 p>0,05 p>0,05 RB cord-005453-4057qib7 632 13 ) ) -RRB- cord-005453-4057qib7 632 14 . . . cord-005453-4057qib7 633 1 RFS RFS NNP cord-005453-4057qib7 633 2 is be VBZ cord-005453-4057qib7 633 3 56 56 CD cord-005453-4057qib7 633 4 % % NN cord-005453-4057qib7 633 5 vs vs IN cord-005453-4057qib7 633 6 83 83 CD cord-005453-4057qib7 633 7 % % NN cord-005453-4057qib7 633 8 accordingly accordingly RB cord-005453-4057qib7 633 9 ( ( -LRB- cord-005453-4057qib7 633 10 p=0,01 p=0,01 NN cord-005453-4057qib7 633 11 ) ) -RRB- cord-005453-4057qib7 633 12 . . . cord-005453-4057qib7 634 1 Graft graft NN cord-005453-4057qib7 634 2 - - HYPH cord-005453-4057qib7 634 3 versus versus IN cord-005453-4057qib7 634 4 - - HYPH cord-005453-4057qib7 634 5 host host NN cord-005453-4057qib7 634 6 - - HYPH cord-005453-4057qib7 634 7 disease disease NN cord-005453-4057qib7 634 8 free free JJ cord-005453-4057qib7 634 9 / / NFP cord-005453-4057qib7 634 10 relapse relapse VB cord-005453-4057qib7 634 11 free free JJ cord-005453-4057qib7 634 12 survival survival NN cord-005453-4057qib7 634 13 ( ( -LRB- cord-005453-4057qib7 634 14 GRFS GRFS NNP cord-005453-4057qib7 634 15 ) ) -RRB- cord-005453-4057qib7 634 16 in in IN cord-005453-4057qib7 634 17 MRD MRD NNP cord-005453-4057qib7 634 18 positive positive JJ cord-005453-4057qib7 634 19 patients patient NNS cord-005453-4057qib7 634 20 is be VBZ cord-005453-4057qib7 634 21 37 37 CD cord-005453-4057qib7 634 22 % % NN cord-005453-4057qib7 634 23 vs vs IN cord-005453-4057qib7 634 24 51 51 CD cord-005453-4057qib7 634 25 % % NN cord-005453-4057qib7 634 26 in in IN cord-005453-4057qib7 634 27 MRD MRD NNP cord-005453-4057qib7 634 28 negative negative JJ cord-005453-4057qib7 634 29 ( ( -LRB- cord-005453-4057qib7 634 30 p>0,05 p>0,05 RB cord-005453-4057qib7 634 31 ) ) -RRB- cord-005453-4057qib7 634 32 . . . cord-005453-4057qib7 635 1 OS OS NNP cord-005453-4057qib7 635 2 , , , cord-005453-4057qib7 635 3 RFS RFS NNP cord-005453-4057qib7 635 4 , , , cord-005453-4057qib7 635 5 GRFS GRFS NNP cord-005453-4057qib7 635 6 in in IN cord-005453-4057qib7 635 7 MRD MRD NNP cord-005453-4057qib7 635 8 positive positive JJ cord-005453-4057qib7 635 9 patients patient NNS cord-005453-4057qib7 635 10 after after IN cord-005453-4057qib7 635 11 MAC MAC NNP cord-005453-4057qib7 635 12 is be VBZ cord-005453-4057qib7 635 13 57 57 CD cord-005453-4057qib7 635 14 % % NN cord-005453-4057qib7 635 15 , , , cord-005453-4057qib7 635 16 42 42 CD cord-005453-4057qib7 635 17 % % NN cord-005453-4057qib7 635 18 , , , cord-005453-4057qib7 635 19 30 30 CD cord-005453-4057qib7 635 20 % % NN cord-005453-4057qib7 635 21 vs vs IN cord-005453-4057qib7 635 22 75 75 CD cord-005453-4057qib7 635 23 % % NN cord-005453-4057qib7 635 24 , , , cord-005453-4057qib7 635 25 68 68 CD cord-005453-4057qib7 635 26 % % NN cord-005453-4057qib7 635 27 , , , cord-005453-4057qib7 635 28 43 43 CD cord-005453-4057qib7 635 29 % % NN cord-005453-4057qib7 635 30 after after IN cord-005453-4057qib7 635 31 RIC RIC NNP cord-005453-4057qib7 635 32 accordingly accordingly RB cord-005453-4057qib7 635 33 ( ( -LRB- cord-005453-4057qib7 635 34 p>0,05 p>0,05 RB cord-005453-4057qib7 635 35 ) ) -RRB- cord-005453-4057qib7 635 36 . . . cord-005453-4057qib7 636 1 OS OS NNP cord-005453-4057qib7 636 2 , , , cord-005453-4057qib7 636 3 RFS RFS NNP cord-005453-4057qib7 636 4 , , , cord-005453-4057qib7 636 5 GRFS GRFS NNP cord-005453-4057qib7 636 6 in in IN cord-005453-4057qib7 636 7 MRD MRD NNP cord-005453-4057qib7 636 8 negative negative JJ cord-005453-4057qib7 636 9 patients patient NNS cord-005453-4057qib7 636 10 after after IN cord-005453-4057qib7 636 11 MAC MAC NNP cord-005453-4057qib7 636 12 is be VBZ cord-005453-4057qib7 636 13 75 75 CD cord-005453-4057qib7 636 14 % % NN cord-005453-4057qib7 636 15 , , , cord-005453-4057qib7 636 16 85 85 CD cord-005453-4057qib7 636 17 % % NN cord-005453-4057qib7 636 18 , , , cord-005453-4057qib7 636 19 55 55 CD cord-005453-4057qib7 636 20 % % NN cord-005453-4057qib7 636 21 vs vs IN cord-005453-4057qib7 636 22 65 65 CD cord-005453-4057qib7 636 23 % % NN cord-005453-4057qib7 636 24 , , , cord-005453-4057qib7 636 25 82 82 CD cord-005453-4057qib7 636 26 % % NN cord-005453-4057qib7 636 27 , , , cord-005453-4057qib7 636 28 47 47 CD cord-005453-4057qib7 636 29 % % NN cord-005453-4057qib7 636 30 after after IN cord-005453-4057qib7 636 31 RIC RIC NNP cord-005453-4057qib7 636 32 accordingly accordingly RB cord-005453-4057qib7 636 33 ( ( -LRB- cord-005453-4057qib7 636 34 p>0,05 p>0,05 RB cord-005453-4057qib7 636 35 ) ) -RRB- cord-005453-4057qib7 636 36 . . . cord-005453-4057qib7 637 1 OS OS NNP cord-005453-4057qib7 637 2 , , , cord-005453-4057qib7 637 3 RFS RFS NNP cord-005453-4057qib7 637 4 in in IN cord-005453-4057qib7 637 5 MRD MRD NNP cord-005453-4057qib7 637 6 negative negative JJ cord-005453-4057qib7 637 7 patients patient NNS cord-005453-4057qib7 637 8 with with IN cord-005453-4057qib7 637 9 / / SYM cord-005453-4057qib7 637 10 without without IN cord-005453-4057qib7 637 11 PTCy PTCy NNS cord-005453-4057qib7 637 12 is be VBZ cord-005453-4057qib7 637 13 82 82 CD cord-005453-4057qib7 637 14 % % NN cord-005453-4057qib7 637 15 , , , cord-005453-4057qib7 637 16 86 86 CD cord-005453-4057qib7 637 17 % % NN cord-005453-4057qib7 637 18 vs vs IN cord-005453-4057qib7 637 19 42 42 CD cord-005453-4057qib7 637 20 % % NN cord-005453-4057qib7 637 21 , , , cord-005453-4057qib7 637 22 78 78 CD cord-005453-4057qib7 637 23 % % NN cord-005453-4057qib7 637 24 ( ( -LRB- cord-005453-4057qib7 637 25 p>0,05 p>0,05 NNP cord-005453-4057qib7 637 26 ) ) -RRB- cord-005453-4057qib7 637 27 ; ; : cord-005453-4057qib7 637 28 GRFS GRFS NNP cord-005453-4057qib7 637 29 is be VBZ cord-005453-4057qib7 637 30 62 62 CD cord-005453-4057qib7 637 31 % % NN cord-005453-4057qib7 637 32 vs vs IN cord-005453-4057qib7 637 33 28 28 CD cord-005453-4057qib7 637 34 % % NN cord-005453-4057qib7 637 35 accordingly accordingly RB cord-005453-4057qib7 637 36 ( ( -LRB- cord-005453-4057qib7 637 37 p=0,042 p=0,042 NNP cord-005453-4057qib7 637 38 ) ) -RRB- cord-005453-4057qib7 637 39 . . . cord-005453-4057qib7 638 1 OS OS NNP cord-005453-4057qib7 638 2 , , , cord-005453-4057qib7 638 3 RFS RFS NNP cord-005453-4057qib7 638 4 , , , cord-005453-4057qib7 638 5 GRFS GRFS NNP cord-005453-4057qib7 638 6 in in IN cord-005453-4057qib7 638 7 MRD MRD NNP cord-005453-4057qib7 638 8 positive positive JJ cord-005453-4057qib7 638 9 patients patient NNS cord-005453-4057qib7 638 10 with with IN cord-005453-4057qib7 638 11 / / SYM cord-005453-4057qib7 638 12 without without IN cord-005453-4057qib7 638 13 PTCy PTCy NNS cord-005453-4057qib7 638 14 is be VBZ cord-005453-4057qib7 638 15 66 66 CD cord-005453-4057qib7 638 16 % % NN cord-005453-4057qib7 638 17 , , , cord-005453-4057qib7 638 18 55 55 CD cord-005453-4057qib7 638 19 % % NN cord-005453-4057qib7 638 20 , , , cord-005453-4057qib7 638 21 54 54 CD cord-005453-4057qib7 638 22 % % NN cord-005453-4057qib7 638 23 vs vs IN cord-005453-4057qib7 638 24 66 66 CD cord-005453-4057qib7 638 25 % % NN cord-005453-4057qib7 638 26 , , , cord-005453-4057qib7 638 27 57 57 CD cord-005453-4057qib7 638 28 % % NN cord-005453-4057qib7 638 29 , , , cord-005453-4057qib7 638 30 27 27 CD cord-005453-4057qib7 638 31 % % NN cord-005453-4057qib7 638 32 ( ( -LRB- cord-005453-4057qib7 638 33 p>0,05 p>0,05 NNP cord-005453-4057qib7 638 34 ) ) -RRB- cord-005453-4057qib7 638 35 . . . cord-005453-4057qib7 639 1 Conclusions conclusion NNS cord-005453-4057qib7 639 2 : : : cord-005453-4057qib7 640 1 MRD MRD NNP cord-005453-4057qib7 640 2 status status NN cord-005453-4057qib7 640 3 does do VBZ cord-005453-4057qib7 640 4 not not RB cord-005453-4057qib7 640 5 statistically statistically RB cord-005453-4057qib7 640 6 significant significant JJ cord-005453-4057qib7 640 7 affect affect NN cord-005453-4057qib7 640 8 on on IN cord-005453-4057qib7 640 9 OS OS NNP cord-005453-4057qib7 640 10 that that WDT cord-005453-4057qib7 640 11 can can MD cord-005453-4057qib7 640 12 be be VB cord-005453-4057qib7 640 13 related relate VBN cord-005453-4057qib7 640 14 to to IN cord-005453-4057qib7 640 15 different different JJ cord-005453-4057qib7 640 16 approaches approach NNS cord-005453-4057qib7 640 17 to to IN cord-005453-4057qib7 640 18 the the DT cord-005453-4057qib7 640 19 treatment treatment NN cord-005453-4057qib7 640 20 of of IN cord-005453-4057qib7 640 21 relapse relapse NN cord-005453-4057qib7 640 22 after after IN cord-005453-4057qib7 640 23 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 640 24 . . . cord-005453-4057qib7 641 1 MRD MRD NNP cord-005453-4057qib7 641 2 positive positive JJ cord-005453-4057qib7 641 3 status status NN cord-005453-4057qib7 641 4 statistically statistically RB cord-005453-4057qib7 641 5 significant significant JJ cord-005453-4057qib7 641 6 decreases decrease VBZ cord-005453-4057qib7 641 7 RFS RFS NNP cord-005453-4057qib7 641 8 that that WDT cord-005453-4057qib7 641 9 underline underline VBP cord-005453-4057qib7 641 10 the the DT cord-005453-4057qib7 641 11 necessity necessity NN cord-005453-4057qib7 641 12 of of IN cord-005453-4057qib7 641 13 posttransplant posttransplant NN cord-005453-4057qib7 641 14 therapy therapy NN cord-005453-4057qib7 641 15 improvement improvement NN cord-005453-4057qib7 641 16 . . . cord-005453-4057qib7 642 1 RIC RIC NNP cord-005453-4057qib7 642 2 vs vs IN cord-005453-4057qib7 642 3 MAC MAC NNP cord-005453-4057qib7 642 4 in in IN cord-005453-4057qib7 642 5 all all DT cord-005453-4057qib7 642 6 patients patient NNS cord-005453-4057qib7 642 7 in in IN cord-005453-4057qib7 642 8 first first JJ cord-005453-4057qib7 642 9 and and CC cord-005453-4057qib7 642 10 second second JJ cord-005453-4057qib7 642 11 remission remission NN cord-005453-4057qib7 642 12 do do VBP cord-005453-4057qib7 642 13 not not RB cord-005453-4057qib7 642 14 show show VB cord-005453-4057qib7 642 15 statistically statistically RB cord-005453-4057qib7 642 16 significant significant JJ cord-005453-4057qib7 642 17 impact impact NN cord-005453-4057qib7 642 18 on on IN cord-005453-4057qib7 642 19 OS OS NNP cord-005453-4057qib7 642 20 , , , cord-005453-4057qib7 642 21 RFS RFS NNP cord-005453-4057qib7 642 22 , , , cord-005453-4057qib7 642 23 GRFS GRFS NNP cord-005453-4057qib7 642 24 . . . cord-005453-4057qib7 643 1 PTCy PTCy NNP cord-005453-4057qib7 643 2 significantly significantly RB cord-005453-4057qib7 643 3 improves improve VBZ cord-005453-4057qib7 643 4 GRFS grfs NN cord-005453-4057qib7 643 5 in in IN cord-005453-4057qib7 643 6 MRD MRD NNP cord-005453-4057qib7 643 7 negative negative JJ cord-005453-4057qib7 643 8 patients patient NNS cord-005453-4057qib7 643 9 . . . cord-005453-4057qib7 644 1 Disclosure disclosure NN cord-005453-4057qib7 644 2 : : : cord-005453-4057qib7 644 3 None none NN cord-005453-4057qib7 644 4 of of IN cord-005453-4057qib7 644 5 the the DT cord-005453-4057qib7 644 6 authors author NNS cord-005453-4057qib7 644 7 has have VBZ cord-005453-4057qib7 644 8 anything anything NN cord-005453-4057qib7 644 9 to to TO cord-005453-4057qib7 644 10 disclose disclose VB cord-005453-4057qib7 644 11 . . . cord-005453-4057qib7 645 1 Background background NN cord-005453-4057qib7 645 2 : : : cord-005453-4057qib7 646 1 With with IN cord-005453-4057qib7 646 2 increasing increase VBG cord-005453-4057qib7 646 3 overall overall JJ cord-005453-4057qib7 646 4 - - HYPH cord-005453-4057qib7 646 5 survival survival NN cord-005453-4057qib7 646 6 ( ( -LRB- cord-005453-4057qib7 646 7 OS OS NNP cord-005453-4057qib7 646 8 ) ) -RRB- cord-005453-4057qib7 646 9 of of IN cord-005453-4057qib7 646 10 lymphoma lymphoma NN cord-005453-4057qib7 646 11 patients patient NNS cord-005453-4057qib7 646 12 , , , cord-005453-4057qib7 646 13 higher high JJR cord-005453-4057qib7 646 14 incidences incidence NNS cord-005453-4057qib7 646 15 of of IN cord-005453-4057qib7 646 16 therapy therapy NN cord-005453-4057qib7 646 17 - - HYPH cord-005453-4057qib7 646 18 related relate VBN cord-005453-4057qib7 646 19 clonal clonal JJ cord-005453-4057qib7 646 20 bone bone NN cord-005453-4057qib7 646 21 marrow marrow NN cord-005453-4057qib7 646 22 diseases disease NNS cord-005453-4057qib7 646 23 , , , cord-005453-4057qib7 646 24 such such JJ cord-005453-4057qib7 646 25 as as IN cord-005453-4057qib7 646 26 acute acute JJ cord-005453-4057qib7 646 27 myeloid myeloid NN cord-005453-4057qib7 646 28 leukemia leukemia NN cord-005453-4057qib7 646 29 ( ( -LRB- cord-005453-4057qib7 646 30 AML AML NNP cord-005453-4057qib7 646 31 ) ) -RRB- cord-005453-4057qib7 646 32 and and CC cord-005453-4057qib7 646 33 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 646 34 syndrome syndrome NN cord-005453-4057qib7 646 35 ( ( -LRB- cord-005453-4057qib7 646 36 MDS MDS NNP cord-005453-4057qib7 646 37 ) ) -RRB- cord-005453-4057qib7 646 38 are be VBP cord-005453-4057qib7 646 39 occuring occur VBG cord-005453-4057qib7 646 40 . . . cord-005453-4057qib7 647 1 Generally generally RB cord-005453-4057qib7 647 2 , , , cord-005453-4057qib7 647 3 the the DT cord-005453-4057qib7 647 4 outcome outcome NN cord-005453-4057qib7 647 5 is be VBZ cord-005453-4057qib7 647 6 considered consider VBN cord-005453-4057qib7 647 7 poor poor JJ cord-005453-4057qib7 647 8 . . . cord-005453-4057qib7 648 1 Allogeneic allogeneic IN cord-005453-4057qib7 648 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 648 3 stem stem NN cord-005453-4057qib7 648 4 cell cell NN cord-005453-4057qib7 648 5 transplantation transplantation NN cord-005453-4057qib7 648 6 ( ( -LRB- cord-005453-4057qib7 648 7 allo allo NNP cord-005453-4057qib7 648 8 HSCT HSCT NNP cord-005453-4057qib7 648 9 ) ) -RRB- cord-005453-4057qib7 648 10 often often RB cord-005453-4057qib7 648 11 remains remain VBZ cord-005453-4057qib7 648 12 the the DT cord-005453-4057qib7 648 13 only only JJ cord-005453-4057qib7 648 14 potentially potentially RB cord-005453-4057qib7 648 15 curative curative JJ cord-005453-4057qib7 648 16 treatment treatment NN cord-005453-4057qib7 648 17 option option NN cord-005453-4057qib7 648 18 . . . cord-005453-4057qib7 649 1 Nonetheless nonetheless RB cord-005453-4057qib7 649 2 , , , cord-005453-4057qib7 649 3 there there EX cord-005453-4057qib7 649 4 is be VBZ cord-005453-4057qib7 649 5 only only RB cord-005453-4057qib7 649 6 little little JJ cord-005453-4057qib7 649 7 data datum NNS cord-005453-4057qib7 649 8 available available JJ cord-005453-4057qib7 649 9 concerning concern VBG cord-005453-4057qib7 649 10 this this DT cord-005453-4057qib7 649 11 patient patient NN cord-005453-4057qib7 649 12 group group NN cord-005453-4057qib7 649 13 . . . cord-005453-4057qib7 650 1 Methods method NNS cord-005453-4057qib7 650 2 : : : cord-005453-4057qib7 650 3 We -PRON- PRP cord-005453-4057qib7 650 4 retrospectively retrospectively RB cord-005453-4057qib7 650 5 collected collect VBD cord-005453-4057qib7 650 6 data datum NNS cord-005453-4057qib7 650 7 from from IN cord-005453-4057qib7 650 8 33 33 CD cord-005453-4057qib7 650 9 patients patient NNS cord-005453-4057qib7 650 10 with with IN cord-005453-4057qib7 650 11 therapy therapy NN cord-005453-4057qib7 650 12 - - HYPH cord-005453-4057qib7 650 13 related relate VBN cord-005453-4057qib7 650 14 AML AML NNP cord-005453-4057qib7 650 15 ( ( -LRB- cord-005453-4057qib7 650 16 tAML taml NN cord-005453-4057qib7 650 17 ) ) -RRB- cord-005453-4057qib7 650 18 and and CC cord-005453-4057qib7 650 19 MDS MDS NNP cord-005453-4057qib7 650 20 ( ( -LRB- cord-005453-4057qib7 650 21 tMDS tmds NN cord-005453-4057qib7 650 22 ) ) -RRB- cord-005453-4057qib7 650 23 after after IN cord-005453-4057qib7 650 24 treatment treatment NN cord-005453-4057qib7 650 25 for for IN cord-005453-4057qib7 650 26 Hodgkin Hodgkin NNP cord-005453-4057qib7 650 27 's 's POS cord-005453-4057qib7 650 28 lymphoma lymphoma NN cord-005453-4057qib7 650 29 ( ( -LRB- cord-005453-4057qib7 650 30 HL HL NNP cord-005453-4057qib7 650 31 ; ; : cord-005453-4057qib7 650 32 n=7 n=7 NNS cord-005453-4057qib7 650 33 and and CC cord-005453-4057qib7 650 34 n=2 n=2 NNS cord-005453-4057qib7 650 35 ) ) -RRB- cord-005453-4057qib7 650 36 or or CC cord-005453-4057qib7 650 37 non non JJ cord-005453-4057qib7 650 38 - - JJ cord-005453-4057qib7 650 39 Hodgkin Hodgkin NNP cord-005453-4057qib7 650 40 's 's POS cord-005453-4057qib7 650 41 lymphoma lymphoma NN cord-005453-4057qib7 650 42 ( ( -LRB- cord-005453-4057qib7 650 43 NHL NHL NNP cord-005453-4057qib7 650 44 ; ; : cord-005453-4057qib7 650 45 n=10 n=10 NNP cord-005453-4057qib7 650 46 and and CC cord-005453-4057qib7 650 47 n=14 n=14 NNP cord-005453-4057qib7 650 48 ) ) -RRB- cord-005453-4057qib7 650 49 , , , cord-005453-4057qib7 650 50 who who WP cord-005453-4057qib7 650 51 received receive VBD cord-005453-4057qib7 650 52 an an DT cord-005453-4057qib7 650 53 allo allo NN cord-005453-4057qib7 650 54 HSCT HSCT NNP cord-005453-4057qib7 650 55 between between IN cord-005453-4057qib7 650 56 2000 2000 CD cord-005453-4057qib7 650 57 and and CC cord-005453-4057qib7 650 58 2018 2018 CD cord-005453-4057qib7 650 59 . . . cord-005453-4057qib7 651 1 Median median JJ cord-005453-4057qib7 651 2 follow follow NN cord-005453-4057qib7 651 3 - - HYPH cord-005453-4057qib7 651 4 up up NN cord-005453-4057qib7 651 5 of of IN cord-005453-4057qib7 651 6 surviving survive VBG cord-005453-4057qib7 651 7 patients patient NNS cord-005453-4057qib7 651 8 was be VBD cord-005453-4057qib7 651 9 3.1 3.1 CD cord-005453-4057qib7 651 10 years year NNS cord-005453-4057qib7 651 11 ( ( -LRB- cord-005453-4057qib7 651 12 range range VBP cord-005453-4057qib7 651 13 2.6 2.6 CD cord-005453-4057qib7 651 14 months-9.4 months-9.4 CD cord-005453-4057qib7 651 15 years year NNS cord-005453-4057qib7 651 16 ) ) -RRB- cord-005453-4057qib7 651 17 . . . cord-005453-4057qib7 652 1 Background background NN cord-005453-4057qib7 652 2 : : : cord-005453-4057qib7 653 1 The the DT cord-005453-4057qib7 653 2 prognosis prognosis NN cord-005453-4057qib7 653 3 of of IN cord-005453-4057qib7 653 4 relapsed relapse VBN cord-005453-4057qib7 653 5 / / SYM cord-005453-4057qib7 653 6 refractory refractory JJ cord-005453-4057qib7 653 7 acute acute JJ cord-005453-4057qib7 653 8 leukemia leukemia NN cord-005453-4057qib7 653 9 ( ( -LRB- cord-005453-4057qib7 653 10 R r NN cord-005453-4057qib7 653 11 / / SYM cord-005453-4057qib7 653 12 R R NNP cord-005453-4057qib7 653 13 AL AL NNP cord-005453-4057qib7 653 14 ) ) -RRB- cord-005453-4057qib7 653 15 is be VBZ cord-005453-4057qib7 653 16 poor poor JJ cord-005453-4057qib7 653 17 and and CC cord-005453-4057qib7 653 18 the the DT cord-005453-4057qib7 653 19 treatment treatment NN cord-005453-4057qib7 653 20 is be VBZ cord-005453-4057qib7 653 21 challenging challenging JJ cord-005453-4057qib7 653 22 . . . cord-005453-4057qib7 654 1 In in IN cord-005453-4057qib7 654 2 this this DT cord-005453-4057qib7 654 3 setting setting NN cord-005453-4057qib7 654 4 , , , cord-005453-4057qib7 654 5 allogeneic allogeneic IN cord-005453-4057qib7 654 6 stem stem NN cord-005453-4057qib7 654 7 cell cell NN cord-005453-4057qib7 654 8 transplantation transplantation NN cord-005453-4057qib7 654 9 ( ( -LRB- cord-005453-4057qib7 654 10 allo allo FW cord-005453-4057qib7 654 11 - - HYPH cord-005453-4057qib7 654 12 SCT SCT NNP cord-005453-4057qib7 654 13 ) ) -RRB- cord-005453-4057qib7 654 14 constitutes constitute VBZ cord-005453-4057qib7 654 15 the the DT cord-005453-4057qib7 654 16 only only JJ cord-005453-4057qib7 654 17 curative curative JJ cord-005453-4057qib7 654 18 option option NN cord-005453-4057qib7 654 19 although although IN cord-005453-4057qib7 654 20 the the DT cord-005453-4057qib7 654 21 high high JJ cord-005453-4057qib7 654 22 relapse relapse NN cord-005453-4057qib7 654 23 rate rate NN cord-005453-4057qib7 654 24 and and CC cord-005453-4057qib7 654 25 non non JJ cord-005453-4057qib7 654 26 - - JJ cord-005453-4057qib7 654 27 relapse relapse JJ cord-005453-4057qib7 654 28 mortality mortality NN cord-005453-4057qib7 654 29 ( ( -LRB- cord-005453-4057qib7 654 30 NRM NRM NNP cord-005453-4057qib7 654 31 ) ) -RRB- cord-005453-4057qib7 654 32 . . . cord-005453-4057qib7 655 1 The the DT cord-005453-4057qib7 655 2 sequential sequential JJ cord-005453-4057qib7 655 3 conditioning conditioning NN cord-005453-4057qib7 655 4 regimen regimen NN cord-005453-4057qib7 655 5 followed follow VBN cord-005453-4057qib7 655 6 by by IN cord-005453-4057qib7 655 7 allo allo NNP cord-005453-4057qib7 655 8 - - HYPH cord-005453-4057qib7 655 9 SCT SCT NNP cord-005453-4057qib7 655 10 has have VBZ cord-005453-4057qib7 655 11 been be VBN cord-005453-4057qib7 655 12 used use VBN cord-005453-4057qib7 655 13 for for IN cord-005453-4057qib7 655 14 persistent persistent JJ cord-005453-4057qib7 655 15 disease disease NN cord-005453-4057qib7 655 16 and and CC cord-005453-4057qib7 655 17 aims aim VBZ cord-005453-4057qib7 655 18 to to TO cord-005453-4057qib7 655 19 improve improve VB cord-005453-4057qib7 655 20 disease disease NN cord-005453-4057qib7 655 21 control control NN cord-005453-4057qib7 655 22 by by IN cord-005453-4057qib7 655 23 intensified intensify VBN cord-005453-4057qib7 655 24 chemotherapy chemotherapy NN cord-005453-4057qib7 655 25 , , , cord-005453-4057qib7 655 26 thus thus RB cord-005453-4057qib7 655 27 conceding concede VBG cord-005453-4057qib7 655 28 more more JJR cord-005453-4057qib7 655 29 time time NN cord-005453-4057qib7 655 30 for for IN cord-005453-4057qib7 655 31 the the DT cord-005453-4057qib7 655 32 presumed presume VBN cord-005453-4057qib7 655 33 graft graft NN cord-005453-4057qib7 655 34 - - HYPH cord-005453-4057qib7 655 35 versus versus IN cord-005453-4057qib7 655 36 - - HYPH cord-005453-4057qib7 655 37 leukemia leukemia NN cord-005453-4057qib7 655 38 effect effect NN cord-005453-4057qib7 655 39 to to TO cord-005453-4057qib7 655 40 occur occur VB cord-005453-4057qib7 655 41 . . . cord-005453-4057qib7 656 1 Methods method NNS cord-005453-4057qib7 656 2 : : : cord-005453-4057qib7 657 1 The the DT cord-005453-4057qib7 657 2 clinical clinical JJ cord-005453-4057qib7 657 3 outcome outcome NN cord-005453-4057qib7 657 4 of of IN cord-005453-4057qib7 657 5 R r NN cord-005453-4057qib7 657 6 / / SYM cord-005453-4057qib7 657 7 R R NNP cord-005453-4057qib7 657 8 AL AL NNP cord-005453-4057qib7 657 9 with with IN cord-005453-4057qib7 657 10 the the DT cord-005453-4057qib7 657 11 sequential sequential JJ cord-005453-4057qib7 657 12 conditioning conditioning NN cord-005453-4057qib7 657 13 regimen regimen NN cord-005453-4057qib7 657 14 combining combine VBG cord-005453-4057qib7 657 15 a a DT cord-005453-4057qib7 657 16 chemotherapy chemotherapy NN cord-005453-4057qib7 657 17 rescue rescue NN cord-005453-4057qib7 657 18 followed follow VBN cord-005453-4057qib7 657 19 by by IN cord-005453-4057qib7 657 20 RIC RIC NNP cord-005453-4057qib7 657 21 allo allo NNP cord-005453-4057qib7 657 22 - - HYPH cord-005453-4057qib7 657 23 SCT SCT NNP cord-005453-4057qib7 657 24 in in IN cord-005453-4057qib7 657 25 our -PRON- PRP$ cord-005453-4057qib7 657 26 center center NN cord-005453-4057qib7 657 27 is be VBZ cord-005453-4057qib7 657 28 described describe VBN cord-005453-4057qib7 657 29 . . . cord-005453-4057qib7 658 1 Patients patient NNS cord-005453-4057qib7 658 2 who who WP cord-005453-4057qib7 658 3 underwent undergo VBD cord-005453-4057qib7 658 4 a a DT cord-005453-4057qib7 658 5 sequential sequential JJ cord-005453-4057qib7 658 6 allo allo NN cord-005453-4057qib7 658 7 - - HYPH cord-005453-4057qib7 658 8 SCT SCT NNP cord-005453-4057qib7 658 9 from from IN cord-005453-4057qib7 658 10 2005 2005 CD cord-005453-4057qib7 658 11 to to IN cord-005453-4057qib7 658 12 2017 2017 CD cord-005453-4057qib7 658 13 are be VBP cord-005453-4057qib7 658 14 included include VBN cord-005453-4057qib7 658 15 . . . cord-005453-4057qib7 659 1 The the DT cord-005453-4057qib7 659 2 primary primary JJ cord-005453-4057qib7 659 3 endpoint endpoint NN cord-005453-4057qib7 659 4 was be VBD cord-005453-4057qib7 659 5 progression progression NN cord-005453-4057qib7 659 6 free free JJ cord-005453-4057qib7 659 7 survival survival NN cord-005453-4057qib7 659 8 ( ( -LRB- cord-005453-4057qib7 659 9 PFS PFS NNP cord-005453-4057qib7 659 10 ) ) -RRB- cord-005453-4057qib7 659 11 and and CC cord-005453-4057qib7 659 12 overall overall JJ cord-005453-4057qib7 659 13 survival survival NN cord-005453-4057qib7 659 14 ( ( -LRB- cord-005453-4057qib7 659 15 OS OS NNP cord-005453-4057qib7 659 16 ) ) -RRB- cord-005453-4057qib7 659 17 that that WDT cord-005453-4057qib7 659 18 were be VBD cord-005453-4057qib7 659 19 estimated estimate VBN cord-005453-4057qib7 659 20 by by IN cord-005453-4057qib7 659 21 the the DT cord-005453-4057qib7 659 22 Kaplan Kaplan NNP cord-005453-4057qib7 659 23 - - HYPH cord-005453-4057qib7 659 24 Meier Meier NNP cord-005453-4057qib7 659 25 method method NN cord-005453-4057qib7 659 26 . . . cord-005453-4057qib7 660 1 Secondary secondary JJ cord-005453-4057qib7 660 2 endpoints endpoint NNS cord-005453-4057qib7 660 3 were be VBD cord-005453-4057qib7 660 4 non non JJ cord-005453-4057qib7 660 5 - - JJ cord-005453-4057qib7 660 6 relapse relapse JJ cord-005453-4057qib7 660 7 mortality mortality NN cord-005453-4057qib7 660 8 ( ( -LRB- cord-005453-4057qib7 660 9 NRM NRM NNP cord-005453-4057qib7 660 10 ) ) -RRB- cord-005453-4057qib7 660 11 . . . cord-005453-4057qib7 661 1 Background background NN cord-005453-4057qib7 661 2 : : : cord-005453-4057qib7 662 1 Recommendations recommendation NNS cord-005453-4057qib7 662 2 of of IN cord-005453-4057qib7 662 3 the the DT cord-005453-4057qib7 662 4 2017 2017 CD cord-005453-4057qib7 662 5 European European NNP cord-005453-4057qib7 662 6 Leukemia Leukemia NNP cord-005453-4057qib7 662 7 Net Net NNP cord-005453-4057qib7 662 8 ( ( -LRB- cord-005453-4057qib7 662 9 ELN ELN NNP cord-005453-4057qib7 662 10 ) ) -RRB- cord-005453-4057qib7 662 11 for for IN cord-005453-4057qib7 662 12 favorable favorable JJ cord-005453-4057qib7 662 13 - - HYPH cord-005453-4057qib7 662 14 risk risk NN cord-005453-4057qib7 662 15 genetics genetic NNS cord-005453-4057qib7 662 16 ( ( -LRB- cord-005453-4057qib7 662 17 FRG FRG NNP cord-005453-4057qib7 662 18 ) ) -RRB- cord-005453-4057qib7 662 19 acute acute JJ cord-005453-4057qib7 662 20 myeloid myeloid NN cord-005453-4057qib7 662 21 leukemia leukemia NN cord-005453-4057qib7 662 22 ( ( -LRB- cord-005453-4057qib7 662 23 AML AML NNP cord-005453-4057qib7 662 24 ) ) -RRB- cord-005453-4057qib7 662 25 favor favor VBP cord-005453-4057qib7 662 26 consolidation consolidation NN cord-005453-4057qib7 662 27 over over IN cord-005453-4057qib7 662 28 transplantation transplantation NN cord-005453-4057qib7 662 29 , , , cord-005453-4057qib7 662 30 although although IN cord-005453-4057qib7 662 31 reviews review NNS cord-005453-4057qib7 662 32 suggest suggest VBP cord-005453-4057qib7 662 33 advantage advantage NN cord-005453-4057qib7 662 34 of of IN cord-005453-4057qib7 662 35 autologous autologous JJ cord-005453-4057qib7 662 36 stem stem NN cord-005453-4057qib7 662 37 cell cell NN cord-005453-4057qib7 662 38 transplant transplant NN cord-005453-4057qib7 662 39 ( ( -LRB- cord-005453-4057qib7 662 40 ASCT ASCT NNP cord-005453-4057qib7 662 41 ) ) -RRB- cord-005453-4057qib7 662 42 in in IN cord-005453-4057qib7 662 43 event event NN cord-005453-4057qib7 662 44 free free JJ cord-005453-4057qib7 662 45 survival survival NN cord-005453-4057qib7 662 46 . . . cord-005453-4057qib7 663 1 Our -PRON- PRP$ cord-005453-4057qib7 663 2 objective objective NN cord-005453-4057qib7 663 3 was be VBD cord-005453-4057qib7 663 4 to to TO cord-005453-4057qib7 663 5 compare compare VB cord-005453-4057qib7 663 6 the the DT cord-005453-4057qib7 663 7 progression progression NN cord-005453-4057qib7 663 8 free free JJ cord-005453-4057qib7 663 9 survival survival NN cord-005453-4057qib7 663 10 ( ( -LRB- cord-005453-4057qib7 663 11 PFS PFS NNP cord-005453-4057qib7 663 12 ) ) -RRB- cord-005453-4057qib7 663 13 and and CC cord-005453-4057qib7 663 14 overall overall JJ cord-005453-4057qib7 663 15 survival survival NN cord-005453-4057qib7 663 16 ( ( -LRB- cord-005453-4057qib7 663 17 OS OS NNP cord-005453-4057qib7 663 18 ) ) -RRB- cord-005453-4057qib7 663 19 of of IN cord-005453-4057qib7 663 20 normal normal JJ cord-005453-4057qib7 663 21 karyotype karyotype NN cord-005453-4057qib7 663 22 NPM1 NPM1 NNP cord-005453-4057qib7 663 23 mutated mutate VBN cord-005453-4057qib7 663 24 without without IN cord-005453-4057qib7 663 25 FLT3 FLT3 NNP cord-005453-4057qib7 663 26 ITD ITD NNP cord-005453-4057qib7 663 27 or or CC cord-005453-4057qib7 663 28 allelic allelic JJ cord-005453-4057qib7 663 29 ratio ratio NN cord-005453-4057qib7 663 30 < < XX cord-005453-4057qib7 663 31 0.5 0.5 CD cord-005453-4057qib7 664 1 ( ( -LRB- cord-005453-4057qib7 664 2 NPM1 NPM1 NNP cord-005453-4057qib7 664 3 + + CD cord-005453-4057qib7 664 4 ) ) -RRB- cord-005453-4057qib7 665 1 AML AML NNP cord-005453-4057qib7 665 2 patients patient NNS cord-005453-4057qib7 665 3 treated treat VBN cord-005453-4057qib7 665 4 with with IN cord-005453-4057qib7 665 5 consolidation consolidation NN cord-005453-4057qib7 665 6 chemotherapy chemotherapy NN cord-005453-4057qib7 665 7 alone alone JJ cord-005453-4057qib7 665 8 ( ( -LRB- cord-005453-4057qib7 665 9 CC CC NNP cord-005453-4057qib7 665 10 ) ) -RRB- cord-005453-4057qib7 665 11 , , , cord-005453-4057qib7 665 12 ASCT ASCT NNP cord-005453-4057qib7 665 13 or or CC cord-005453-4057qib7 665 14 allogeneic allogeneic IN cord-005453-4057qib7 665 15 stem stem NN cord-005453-4057qib7 665 16 cell cell NN cord-005453-4057qib7 665 17 transplant transplant NN cord-005453-4057qib7 665 18 ( ( -LRB- cord-005453-4057qib7 665 19 AlloSCT AlloSCT NNP cord-005453-4057qib7 665 20 ) ) -RRB- cord-005453-4057qib7 665 21 . . . cord-005453-4057qib7 666 1 Methods method NNS cord-005453-4057qib7 666 2 : : : cord-005453-4057qib7 666 3 Retrospective retrospective JJ cord-005453-4057qib7 666 4 review review NN cord-005453-4057qib7 666 5 of of IN cord-005453-4057qib7 666 6 NPM1 NPM1 NNP cord-005453-4057qib7 666 7 + + SYM cord-005453-4057qib7 666 8 FRG FRG NNP cord-005453-4057qib7 666 9 - - HYPH cord-005453-4057qib7 666 10 AML AML NNP cord-005453-4057qib7 666 11 patients patient NNS cord-005453-4057qib7 666 12 , , , cord-005453-4057qib7 666 13 treated treat VBN cord-005453-4057qib7 666 14 in in IN cord-005453-4057qib7 666 15 one one CD cord-005453-4057qib7 666 16 institution institution NN cord-005453-4057qib7 666 17 ( ( -LRB- cord-005453-4057qib7 666 18 2008 2008 CD cord-005453-4057qib7 666 19 to to IN cord-005453-4057qib7 666 20 2017 2017 CD cord-005453-4057qib7 666 21 ) ) -RRB- cord-005453-4057qib7 666 22 with with IN cord-005453-4057qib7 666 23 the the DT cord-005453-4057qib7 666 24 following following JJ cord-005453-4057qib7 666 25 induction induction NN cord-005453-4057qib7 666 26 regimens regimen NNS cord-005453-4057qib7 666 27 : : : cord-005453-4057qib7 666 28 cytarabine cytarabine NNP cord-005453-4057qib7 666 29 ( ( -LRB- cord-005453-4057qib7 666 30 Ara Ara NNP cord-005453-4057qib7 666 31 - - HYPH cord-005453-4057qib7 666 32 C C NNP cord-005453-4057qib7 666 33 ) ) -RRB- cord-005453-4057qib7 666 34 and and CC cord-005453-4057qib7 666 35 VP-16 VP-16 NNP cord-005453-4057qib7 666 36 with with IN cord-005453-4057qib7 666 37 daunorubicin daunorubicin NNS cord-005453-4057qib7 666 38 ( ( -LRB- cord-005453-4057qib7 666 39 ADE ADE NNP cord-005453-4057qib7 666 40 ) ) -RRB- cord-005453-4057qib7 666 41 or or CC cord-005453-4057qib7 666 42 mitoxantrone mitoxantrone NNP cord-005453-4057qib7 666 43 ( ( -LRB- cord-005453-4057qib7 666 44 MiCE MiCE NNP cord-005453-4057qib7 666 45 ) ) -RRB- cord-005453-4057qib7 666 46 . . . cord-005453-4057qib7 667 1 Consolidation consolidation NN cord-005453-4057qib7 667 2 regimens regimen NNS cord-005453-4057qib7 667 3 were be VBD cord-005453-4057qib7 667 4 Ara Ara NNP cord-005453-4057qib7 667 5 - - HYPH cord-005453-4057qib7 667 6 C C NNP cord-005453-4057qib7 667 7 with with IN cord-005453-4057qib7 667 8 daunorubicin daunorubicin NNS cord-005453-4057qib7 667 9 ( ( -LRB- cord-005453-4057qib7 667 10 AC ac NN cord-005453-4057qib7 667 11 - - HYPH cord-005453-4057qib7 667 12 D D NNP cord-005453-4057qib7 667 13 ) ) -RRB- cord-005453-4057qib7 667 14 , , , cord-005453-4057qib7 667 15 idarubicin idarubicin NNS cord-005453-4057qib7 667 16 , , , cord-005453-4057qib7 667 17 VP-16 VP-16 NNP cord-005453-4057qib7 667 18 and and CC cord-005453-4057qib7 667 19 Ara Ara NNP cord-005453-4057qib7 667 20 - - HYPH cord-005453-4057qib7 667 21 C C NNP cord-005453-4057qib7 667 22 ( ( -LRB- cord-005453-4057qib7 667 23 mini mini NN cord-005453-4057qib7 667 24 - - NN cord-005453-4057qib7 667 25 ICE ice NN cord-005453-4057qib7 667 26 ) ) -RRB- cord-005453-4057qib7 667 27 or or CC cord-005453-4057qib7 667 28 highdose highdose NNP cord-005453-4057qib7 667 29 Ara Ara NNP cord-005453-4057qib7 667 30 - - HYPH cord-005453-4057qib7 667 31 C C NNP cord-005453-4057qib7 667 32 ( ( -LRB- cord-005453-4057qib7 667 33 HiDAC HiDAC NNP cord-005453-4057qib7 667 34 ) ) -RRB- cord-005453-4057qib7 667 35 . . . cord-005453-4057qib7 668 1 In in IN cord-005453-4057qib7 668 2 ASCT ASCT NNP cord-005453-4057qib7 668 3 , , , cord-005453-4057qib7 668 4 conditioning conditioning NN cord-005453-4057qib7 668 5 regimens regimen NNS cord-005453-4057qib7 668 6 were be VBD cord-005453-4057qib7 668 7 BuCy BuCy NNP cord-005453-4057qib7 668 8 or or CC cord-005453-4057qib7 668 9 BVAC BVAC NNP cord-005453-4057qib7 668 10 and and CC cord-005453-4057qib7 668 11 in in IN cord-005453-4057qib7 668 12 AlloSCT AlloSCT NNP cord-005453-4057qib7 668 13 were be VBD cord-005453-4057qib7 668 14 BuCy BuCy NNP cord-005453-4057qib7 668 15 or or CC cord-005453-4057qib7 668 16 FluBu flubu NN cord-005453-4057qib7 668 17 . . . cord-005453-4057qib7 669 1 PFS PFS NNP cord-005453-4057qib7 669 2 and and CC cord-005453-4057qib7 669 3 OS OS NNP cord-005453-4057qib7 669 4 were be VBD cord-005453-4057qib7 669 5 calculated calculate VBN cord-005453-4057qib7 669 6 from from IN cord-005453-4057qib7 669 7 the the DT cord-005453-4057qib7 669 8 start start NN cord-005453-4057qib7 669 9 of of IN cord-005453-4057qib7 669 10 the the DT cord-005453-4057qib7 669 11 last last JJ cord-005453-4057qib7 669 12 consolidation consolidation NN cord-005453-4057qib7 669 13 or or CC cord-005453-4057qib7 669 14 stem stem NN cord-005453-4057qib7 669 15 cell cell NN cord-005453-4057qib7 669 16 infusion infusion NN cord-005453-4057qib7 669 17 . . . cord-005453-4057qib7 670 1 Results result NNS cord-005453-4057qib7 670 2 : : : cord-005453-4057qib7 671 1 A a DT cord-005453-4057qib7 671 2 total total NN cord-005453-4057qib7 671 3 of of IN cord-005453-4057qib7 671 4 39 39 CD cord-005453-4057qib7 671 5 patients patient NNS cord-005453-4057qib7 671 6 were be VBD cord-005453-4057qib7 671 7 evaluated evaluate VBN cord-005453-4057qib7 671 8 , , , cord-005453-4057qib7 671 9 with with IN cord-005453-4057qib7 671 10 a a DT cord-005453-4057qib7 671 11 median median JJ cord-005453-4057qib7 671 12 age age NN cord-005453-4057qib7 671 13 of of IN cord-005453-4057qib7 671 14 53 53 CD cord-005453-4057qib7 671 15 years year NNS cord-005453-4057qib7 671 16 ( ( -LRB- cord-005453-4057qib7 671 17 y y NN cord-005453-4057qib7 671 18 ) ) -RRB- cord-005453-4057qib7 671 19 ( ( -LRB- cord-005453-4057qib7 671 20 23 23 CD cord-005453-4057qib7 671 21 - - SYM cord-005453-4057qib7 671 22 68y 68y CD cord-005453-4057qib7 671 23 ) ) -RRB- cord-005453-4057qib7 671 24 , , , cord-005453-4057qib7 671 25 69 69 CD cord-005453-4057qib7 671 26 % % NN cord-005453-4057qib7 671 27 female female JJ cord-005453-4057qib7 671 28 , , , cord-005453-4057qib7 671 29 95 95 CD cord-005453-4057qib7 671 30 % % NN cord-005453-4057qib7 671 31 with with IN cord-005453-4057qib7 671 32 ECOG ECOG NNP cord-005453-4057qib7 671 33 performance performance NN cord-005453-4057qib7 671 34 status status NN cord-005453-4057qib7 671 35 ( ( -LRB- cord-005453-4057qib7 671 36 PS ps NN cord-005453-4057qib7 671 37 ) ) -RRB- cord-005453-4057qib7 671 38 0 0 CD cord-005453-4057qib7 671 39 - - SYM cord-005453-4057qib7 671 40 1 1 CD cord-005453-4057qib7 671 41 and and CC cord-005453-4057qib7 671 42 36 36 CD cord-005453-4057qib7 671 43 % % NN cord-005453-4057qib7 671 44 with with IN cord-005453-4057qib7 671 45 ageadjusted ageadjuste VBN cord-005453-4057qib7 671 46 Charlson Charlson NNP cord-005453-4057qib7 671 47 comorbidity comorbidity NN cord-005453-4057qib7 671 48 index index NN cord-005453-4057qib7 671 49 ( ( -LRB- cord-005453-4057qib7 671 50 aaCII aacii NN cord-005453-4057qib7 671 51 ) ) -RRB- cord-005453-4057qib7 671 52 ≥2 ≥2 NNP cord-005453-4057qib7 671 53 at at IN cord-005453-4057qib7 671 54 diagnosis diagnosis NN cord-005453-4057qib7 671 55 . . . cord-005453-4057qib7 672 1 Patients patient NNS cord-005453-4057qib7 672 2 were be VBD cord-005453-4057qib7 672 3 treated treat VBN cord-005453-4057qib7 672 4 with with IN cord-005453-4057qib7 672 5 CC CC NNP cord-005453-4057qib7 672 6 in in IN cord-005453-4057qib7 672 7 33 33 CD cord-005453-4057qib7 672 8 % % NN cord-005453-4057qib7 672 9 ( ( -LRB- cord-005453-4057qib7 672 10 n=13 n=13 NNP cord-005453-4057qib7 672 11 ) ) -RRB- cord-005453-4057qib7 672 12 , , , cord-005453-4057qib7 672 13 ASCT ASCT NNP cord-005453-4057qib7 672 14 in in IN cord-005453-4057qib7 672 15 36 36 CD cord-005453-4057qib7 672 16 % % NN cord-005453-4057qib7 672 17 ( ( -LRB- cord-005453-4057qib7 672 18 n=14 n=14 NNP cord-005453-4057qib7 672 19 ) ) -RRB- cord-005453-4057qib7 672 20 and and CC cord-005453-4057qib7 672 21 AlloSCT allosct NN cord-005453-4057qib7 672 22 in in IN cord-005453-4057qib7 672 23 21 21 CD cord-005453-4057qib7 672 24 % % NN cord-005453-4057qib7 672 25 ( ( -LRB- cord-005453-4057qib7 672 26 n=12 n=12 NNP cord-005453-4057qib7 672 27 ) ) -RRB- cord-005453-4057qib7 672 28 of of IN cord-005453-4057qib7 672 29 cases case NNS cord-005453-4057qib7 672 30 . . . cord-005453-4057qib7 673 1 There there EX cord-005453-4057qib7 673 2 were be VBD cord-005453-4057qib7 673 3 no no DT cord-005453-4057qib7 673 4 differences difference NNS cord-005453-4057qib7 673 5 between between IN cord-005453-4057qib7 673 6 groups group NNS cord-005453-4057qib7 673 7 for for IN cord-005453-4057qib7 673 8 age age NN cord-005453-4057qib7 673 9 , , , cord-005453-4057qib7 673 10 aaCII aaCII -RRB- cord-005453-4057qib7 673 11 , , , cord-005453-4057qib7 673 12 PS PS NNP cord-005453-4057qib7 673 13 , , , cord-005453-4057qib7 673 14 leucocytes leucocyte NNS cord-005453-4057qib7 673 15 at at IN cord-005453-4057qib7 673 16 diagnosis diagnosis NN cord-005453-4057qib7 673 17 or or CC cord-005453-4057qib7 673 18 extra extra JJ cord-005453-4057qib7 673 19 - - JJ cord-005453-4057qib7 673 20 medullary medullary JJ cord-005453-4057qib7 673 21 disease disease NN cord-005453-4057qib7 673 22 . . . cord-005453-4057qib7 674 1 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 674 2 was be VBD cord-005453-4057qib7 674 3 more more RBR cord-005453-4057qib7 674 4 frequent frequent JJ cord-005453-4057qib7 674 5 in in IN cord-005453-4057qib7 674 6 AlloSCT AlloSCT NNP cord-005453-4057qib7 674 7 group group NN cord-005453-4057qib7 674 8 ( ( -LRB- cord-005453-4057qib7 674 9 64 64 CD cord-005453-4057qib7 674 10 % % NN cord-005453-4057qib7 674 11 ) ) -RRB- cord-005453-4057qib7 674 12 than than IN cord-005453-4057qib7 674 13 CC CC NNP cord-005453-4057qib7 674 14 ( ( -LRB- cord-005453-4057qib7 674 15 23 23 CD cord-005453-4057qib7 674 16 % % NN cord-005453-4057qib7 674 17 ) ) -RRB- cord-005453-4057qib7 674 18 or or CC cord-005453-4057qib7 674 19 ASCT ASCT NNP cord-005453-4057qib7 674 20 ( ( -LRB- cord-005453-4057qib7 674 21 8 8 CD cord-005453-4057qib7 674 22 % % NN cord-005453-4057qib7 674 23 ; ; : cord-005453-4057qib7 674 24 p=0.07 p=0.07 NNP cord-005453-4057qib7 674 25 ) ) -RRB- cord-005453-4057qib7 674 26 . . . cord-005453-4057qib7 675 1 At at IN cord-005453-4057qib7 675 2 induction induction NN cord-005453-4057qib7 675 3 , , , cord-005453-4057qib7 675 4 ADE ADE NNP cord-005453-4057qib7 675 5 was be VBD cord-005453-4057qib7 675 6 used use VBN cord-005453-4057qib7 675 7 in in IN cord-005453-4057qib7 675 8 82 82 CD cord-005453-4057qib7 675 9 % % NN cord-005453-4057qib7 675 10 and and CC cord-005453-4057qib7 675 11 MiCE MiCE NNP cord-005453-4057qib7 675 12 in in IN cord-005453-4057qib7 675 13 18 18 CD cord-005453-4057qib7 675 14 % % NN cord-005453-4057qib7 675 15 of of IN cord-005453-4057qib7 675 16 patients patient NNS cord-005453-4057qib7 675 17 , , , cord-005453-4057qib7 675 18 with with IN cord-005453-4057qib7 675 19 a a DT cord-005453-4057qib7 675 20 complete complete JJ cord-005453-4057qib7 675 21 remission remission NN cord-005453-4057qib7 675 22 ( ( -LRB- cord-005453-4057qib7 675 23 CR cr NN cord-005453-4057qib7 675 24 ) ) -RRB- cord-005453-4057qib7 675 25 rate rate NN cord-005453-4057qib7 675 26 of of IN cord-005453-4057qib7 675 27 95 95 CD cord-005453-4057qib7 675 28 % % NN cord-005453-4057qib7 675 29 . . . cord-005453-4057qib7 676 1 There there EX cord-005453-4057qib7 676 2 were be VBD cord-005453-4057qib7 676 3 no no DT cord-005453-4057qib7 676 4 differences difference NNS cord-005453-4057qib7 676 5 between between IN cord-005453-4057qib7 676 6 groups group NNS cord-005453-4057qib7 676 7 for for IN cord-005453-4057qib7 676 8 induction induction NN cord-005453-4057qib7 676 9 regimen regimen NN cord-005453-4057qib7 676 10 or or CC cord-005453-4057qib7 676 11 CR CR NNP cord-005453-4057qib7 676 12 . . . cord-005453-4057qib7 677 1 In in IN cord-005453-4057qib7 677 2 CC CC NNP cord-005453-4057qib7 677 3 group group NN cord-005453-4057qib7 677 4 , , , cord-005453-4057qib7 677 5 consolidation consolidation NN cord-005453-4057qib7 677 6 regimens regimen NNS cord-005453-4057qib7 677 7 were be VBD cord-005453-4057qib7 677 8 1 1 CD cord-005453-4057qib7 677 9 cycle cycle NN cord-005453-4057qib7 677 10 ( ( -LRB- cord-005453-4057qib7 677 11 8 8 CD cord-005453-4057qib7 677 12 % % NN cord-005453-4057qib7 677 13 ) ) -RRB- cord-005453-4057qib7 677 14 and and CC cord-005453-4057qib7 677 15 2 2 CD cord-005453-4057qib7 677 16 cycles cycle NNS cord-005453-4057qib7 677 17 AC ac NN cord-005453-4057qib7 677 18 - - HYPH cord-005453-4057qib7 677 19 D D NNP cord-005453-4057qib7 677 20 ( ( -LRB- cord-005453-4057qib7 677 21 61 61 CD cord-005453-4057qib7 677 22 % % NN cord-005453-4057qib7 677 23 ) ) -RRB- cord-005453-4057qib7 677 24 and and CC cord-005453-4057qib7 677 25 2 2 CD cord-005453-4057qib7 677 26 cycles cycle NNS cord-005453-4057qib7 677 27 mini mini NN cord-005453-4057qib7 677 28 - - HYPH cord-005453-4057qib7 677 29 ICE ice NN cord-005453-4057qib7 677 30 ( ( -LRB- cord-005453-4057qib7 677 31 31 31 CD cord-005453-4057qib7 677 32 % % NN cord-005453-4057qib7 677 33 ) ) -RRB- cord-005453-4057qib7 677 34 . . . cord-005453-4057qib7 678 1 ASCT ASCT NNP cord-005453-4057qib7 678 2 patients patient NNS cord-005453-4057qib7 678 3 received receive VBD cord-005453-4057qib7 678 4 consolidation consolidation NN cord-005453-4057qib7 678 5 with with IN cord-005453-4057qib7 678 6 1 1 CD cord-005453-4057qib7 678 7 - - SYM cord-005453-4057qib7 678 8 2 2 CD cord-005453-4057qib7 678 9 cycles cycle NNS cord-005453-4057qib7 678 10 AC ac NN cord-005453-4057qib7 678 11 - - HYPH cord-005453-4057qib7 678 12 D D NNP cord-005453-4057qib7 678 13 ( ( -LRB- cord-005453-4057qib7 678 14 78 78 CD cord-005453-4057qib7 678 15 % % NN cord-005453-4057qib7 678 16 ) ) -RRB- cord-005453-4057qib7 678 17 and and CC cord-005453-4057qib7 678 18 1 1 CD cord-005453-4057qib7 678 19 cycle cycle NN cord-005453-4057qib7 678 20 mini mini NN cord-005453-4057qib7 678 21 - - HYPH cord-005453-4057qib7 678 22 ICE ice NN cord-005453-4057qib7 678 23 ( ( -LRB- cord-005453-4057qib7 678 24 22 22 CD cord-005453-4057qib7 678 25 % % NN cord-005453-4057qib7 678 26 ) ) -RRB- cord-005453-4057qib7 678 27 , , , cord-005453-4057qib7 678 28 while while IN cord-005453-4057qib7 678 29 AlloSCT AlloSCT NNP cord-005453-4057qib7 678 30 patients patient NNS cord-005453-4057qib7 678 31 received receive VBD cord-005453-4057qib7 678 32 1 1 CD cord-005453-4057qib7 678 33 - - SYM cord-005453-4057qib7 678 34 2 2 CD cord-005453-4057qib7 678 35 cycles cycle NNS cord-005453-4057qib7 678 36 AC ac NN cord-005453-4057qib7 678 37 - - HYPH cord-005453-4057qib7 678 38 D D NNP cord-005453-4057qib7 678 39 ( ( -LRB- cord-005453-4057qib7 678 40 84 84 CD cord-005453-4057qib7 678 41 % % NN cord-005453-4057qib7 678 42 ) ) -RRB- cord-005453-4057qib7 678 43 , , , cord-005453-4057qib7 678 44 2 2 CD cord-005453-4057qib7 678 45 cycles cycle NNS cord-005453-4057qib7 678 46 HiDAC HiDAC NNP cord-005453-4057qib7 678 47 ( ( -LRB- cord-005453-4057qib7 678 48 8 8 CD cord-005453-4057qib7 678 49 % % NN cord-005453-4057qib7 678 50 ) ) -RRB- cord-005453-4057qib7 678 51 and and CC cord-005453-4057qib7 678 52 no no DT cord-005453-4057qib7 678 53 consolidation consolidation NN cord-005453-4057qib7 678 54 in in IN cord-005453-4057qib7 678 55 8 8 CD cord-005453-4057qib7 678 56 % % NN cord-005453-4057qib7 678 57 . . . cord-005453-4057qib7 679 1 [ [ -LRB- cord-005453-4057qib7 679 2 [ [ -LRB- cord-005453-4057qib7 679 3 P037 p037 CD cord-005453-4057qib7 679 4 Image image NN cord-005453-4057qib7 679 5 ] ] -RRB- cord-005453-4057qib7 679 6 1 1 CD cord-005453-4057qib7 679 7 . . . cord-005453-4057qib7 680 1 Figure figure NN cord-005453-4057qib7 680 2 1 1 CD cord-005453-4057qib7 680 3 . . . cord-005453-4057qib7 681 1 PFS PFS NNP cord-005453-4057qib7 681 2 at at IN cord-005453-4057qib7 681 3 3y 3y CD cord-005453-4057qib7 681 4 in in IN cord-005453-4057qib7 681 5 CC CC NNP cord-005453-4057qib7 681 6 , , , cord-005453-4057qib7 681 7 ASCT ASCT NNP cord-005453-4057qib7 681 8 and and CC cord-005453-4057qib7 681 9 AlloSCT AlloSCT NNP cord-005453-4057qib7 681 10 groups group NNS cord-005453-4057qib7 681 11 . . . cord-005453-4057qib7 681 12 ] ] -RRB- cord-005453-4057qib7 682 1 Median median JJ cord-005453-4057qib7 682 2 follow follow NN cord-005453-4057qib7 682 3 - - HYPH cord-005453-4057qib7 682 4 up up NN cord-005453-4057qib7 682 5 was be VBD cord-005453-4057qib7 682 6 39 39 CD cord-005453-4057qib7 682 7 months month NNS cord-005453-4057qib7 682 8 , , , cord-005453-4057qib7 682 9 PFS PFS NNP cord-005453-4057qib7 682 10 at at IN cord-005453-4057qib7 682 11 3y 3y CD cord-005453-4057qib7 682 12 was be VBD cord-005453-4057qib7 682 13 53 53 CD cord-005453-4057qib7 682 14 % % NN cord-005453-4057qib7 682 15 and and CC cord-005453-4057qib7 682 16 OS os NN cord-005453-4057qib7 682 17 at at IN cord-005453-4057qib7 682 18 3y 3y CD cord-005453-4057qib7 682 19 was be VBD cord-005453-4057qib7 682 20 64 64 CD cord-005453-4057qib7 682 21 % % NN cord-005453-4057qib7 682 22 . . . cord-005453-4057qib7 683 1 PFS PFS NNP cord-005453-4057qib7 683 2 at at IN cord-005453-4057qib7 683 3 3y 3y CD cord-005453-4057qib7 683 4 for for IN cord-005453-4057qib7 683 5 ASCT ASCT NNP cord-005453-4057qib7 683 6 group group NN cord-005453-4057qib7 683 7 was be VBD cord-005453-4057qib7 683 8 superior superior JJ cord-005453-4057qib7 683 9 then then RB cord-005453-4057qib7 683 10 CC CC NNP cord-005453-4057qib7 683 11 and and CC cord-005453-4057qib7 683 12 AlloSCT AlloSCT NNP cord-005453-4057qib7 683 13 groups group NNS cord-005453-4057qib7 683 14 ( ( -LRB- cord-005453-4057qib7 683 15 61 61 CD cord-005453-4057qib7 683 16 % % NN cord-005453-4057qib7 683 17 , , , cord-005453-4057qib7 683 18 51 51 CD cord-005453-4057qib7 683 19 % % NN cord-005453-4057qib7 683 20 and and CC cord-005453-4057qib7 683 21 44 44 CD cord-005453-4057qib7 683 22 % % NN cord-005453-4057qib7 683 23 , , , cord-005453-4057qib7 683 24 respectively respectively RB cord-005453-4057qib7 683 25 ; ; : cord-005453-4057qib7 683 26 Figure figure NN cord-005453-4057qib7 683 27 1 1 CD cord-005453-4057qib7 683 28 ) ) -RRB- cord-005453-4057qib7 683 29 , , , cord-005453-4057qib7 683 30 although although IN cord-005453-4057qib7 683 31 not not RB cord-005453-4057qib7 683 32 statistically statistically RB cord-005453-4057qib7 683 33 significant significant JJ cord-005453-4057qib7 683 34 . . . cord-005453-4057qib7 684 1 OS OS NNP cord-005453-4057qib7 684 2 at at IN cord-005453-4057qib7 684 3 3y 3y CD cord-005453-4057qib7 684 4 was be VBD cord-005453-4057qib7 684 5 statistically statistically RB cord-005453-4057qib7 684 6 similar similar JJ cord-005453-4057qib7 684 7 between between IN cord-005453-4057qib7 684 8 groups group NNS cord-005453-4057qib7 684 9 , , , cord-005453-4057qib7 684 10 although although IN cord-005453-4057qib7 684 11 inferior inferior JJ cord-005453-4057qib7 684 12 in in IN cord-005453-4057qib7 684 13 AlloSCT AlloSCT NNP cord-005453-4057qib7 684 14 comparing compare VBG cord-005453-4057qib7 684 15 to to IN cord-005453-4057qib7 684 16 CC CC NNP cord-005453-4057qib7 684 17 and and CC cord-005453-4057qib7 684 18 ASCT ASCT NNP cord-005453-4057qib7 684 19 ( ( -LRB- cord-005453-4057qib7 684 20 44 44 CD cord-005453-4057qib7 684 21 % % NN cord-005453-4057qib7 684 22 , , , cord-005453-4057qib7 684 23 77 77 CD cord-005453-4057qib7 684 24 % % NN cord-005453-4057qib7 684 25 and and CC cord-005453-4057qib7 684 26 70 70 CD cord-005453-4057qib7 684 27 % % NN cord-005453-4057qib7 684 28 , , , cord-005453-4057qib7 684 29 respectively respectively RB cord-005453-4057qib7 684 30 ) ) -RRB- cord-005453-4057qib7 684 31 . . . cord-005453-4057qib7 685 1 Conclusions conclusion NNS cord-005453-4057qib7 685 2 : : : cord-005453-4057qib7 686 1 In in IN cord-005453-4057qib7 686 2 this this DT cord-005453-4057qib7 686 3 historical historical JJ cord-005453-4057qib7 686 4 cohort cohort NN cord-005453-4057qib7 686 5 review review NN cord-005453-4057qib7 686 6 , , , cord-005453-4057qib7 686 7 although although IN cord-005453-4057qib7 686 8 there there EX cord-005453-4057qib7 686 9 was be VBD cord-005453-4057qib7 686 10 no no DT cord-005453-4057qib7 686 11 advantage advantage NN cord-005453-4057qib7 686 12 in in IN cord-005453-4057qib7 686 13 OS OS NNP cord-005453-4057qib7 686 14 for for IN cord-005453-4057qib7 686 15 ASCT ASCT NNP cord-005453-4057qib7 686 16 in in IN cord-005453-4057qib7 686 17 NPM1 NPM1 NNP cord-005453-4057qib7 686 18 + + SYM cord-005453-4057qib7 686 19 FRG FRG NNP cord-005453-4057qib7 686 20 AML AML NNP cord-005453-4057qib7 686 21 , , , cord-005453-4057qib7 686 22 our -PRON- PRP$ cord-005453-4057qib7 686 23 data datum NNS cord-005453-4057qib7 686 24 suggests suggest VBZ cord-005453-4057qib7 686 25 that that IN cord-005453-4057qib7 686 26 there there EX cord-005453-4057qib7 686 27 might may MD cord-005453-4057qib7 686 28 be be VB cord-005453-4057qib7 686 29 a a DT cord-005453-4057qib7 686 30 PFS PFS NNP cord-005453-4057qib7 686 31 improvement improvement NN cord-005453-4057qib7 686 32 in in IN cord-005453-4057qib7 686 33 ASCT ASCT NNP cord-005453-4057qib7 686 34 over over IN cord-005453-4057qib7 686 35 CC CC NNP cord-005453-4057qib7 686 36 , , , cord-005453-4057qib7 686 37 which which WDT cord-005453-4057qib7 686 38 needs need VBZ cord-005453-4057qib7 686 39 to to TO cord-005453-4057qib7 686 40 be be VB cord-005453-4057qib7 686 41 further further RB cord-005453-4057qib7 686 42 addressed address VBN cord-005453-4057qib7 686 43 in in IN cord-005453-4057qib7 686 44 prospective prospective JJ cord-005453-4057qib7 686 45 studies study NNS cord-005453-4057qib7 686 46 . . . cord-005453-4057qib7 687 1 Disclosure disclosure NN cord-005453-4057qib7 687 2 : : : cord-005453-4057qib7 687 3 Nothing nothing NN cord-005453-4057qib7 687 4 to to TO cord-005453-4057qib7 687 5 declare declare VB cord-005453-4057qib7 687 6 Background background NN cord-005453-4057qib7 687 7 : : : cord-005453-4057qib7 688 1 Acute acute JJ cord-005453-4057qib7 688 2 myeloid myeloid NN cord-005453-4057qib7 688 3 leukemia leukemia NN cord-005453-4057qib7 688 4 is be VBZ cord-005453-4057qib7 688 5 a a DT cord-005453-4057qib7 688 6 hematological hematological JJ cord-005453-4057qib7 688 7 malignant malignant JJ cord-005453-4057qib7 688 8 disease disease NN cord-005453-4057qib7 688 9 that that WDT cord-005453-4057qib7 688 10 motivates motivate VBZ cord-005453-4057qib7 688 11 the the DT cord-005453-4057qib7 688 12 persistent persistent JJ cord-005453-4057qib7 688 13 struggle struggle NN cord-005453-4057qib7 688 14 in in IN cord-005453-4057qib7 688 15 the the DT cord-005453-4057qib7 688 16 scientific scientific JJ cord-005453-4057qib7 688 17 world world NN cord-005453-4057qib7 688 18 to to TO cord-005453-4057qib7 688 19 provide provide VB cord-005453-4057qib7 688 20 effective effective JJ cord-005453-4057qib7 688 21 cure cure NN cord-005453-4057qib7 688 22 that that WDT cord-005453-4057qib7 688 23 can can MD cord-005453-4057qib7 688 24 establish establish VB cord-005453-4057qib7 688 25 acceptable acceptable JJ cord-005453-4057qib7 688 26 survival survival NN cord-005453-4057qib7 688 27 rates rate NNS cord-005453-4057qib7 688 28 in in IN cord-005453-4057qib7 688 29 this this DT cord-005453-4057qib7 688 30 group group NN cord-005453-4057qib7 688 31 of of IN cord-005453-4057qib7 688 32 patients patient NNS cord-005453-4057qib7 688 33 . . . cord-005453-4057qib7 689 1 Autologous autologous JJ cord-005453-4057qib7 689 2 stem stem NN cord-005453-4057qib7 689 3 cell cell NN cord-005453-4057qib7 689 4 transplantation transplantation NN cord-005453-4057qib7 689 5 with with IN cord-005453-4057qib7 689 6 myeloablative myeloablative JJ cord-005453-4057qib7 689 7 conditioning conditioning NN cord-005453-4057qib7 689 8 is be VBZ cord-005453-4057qib7 689 9 still still RB cord-005453-4057qib7 689 10 a a DT cord-005453-4057qib7 689 11 powerful powerful JJ cord-005453-4057qib7 689 12 weapon weapon NN cord-005453-4057qib7 689 13 that that WDT cord-005453-4057qib7 689 14 can can MD cord-005453-4057qib7 689 15 be be VB cord-005453-4057qib7 689 16 used use VBN cord-005453-4057qib7 689 17 against against IN cord-005453-4057qib7 689 18 this this DT cord-005453-4057qib7 689 19 entity entity NN cord-005453-4057qib7 689 20 Methods method NNS cord-005453-4057qib7 689 21 : : : cord-005453-4057qib7 689 22 We -PRON- PRP cord-005453-4057qib7 689 23 have have VBP cord-005453-4057qib7 689 24 evaluated evaluate VBN cord-005453-4057qib7 689 25 retrospectively retrospectively RB cord-005453-4057qib7 689 26 patients patient NNS cord-005453-4057qib7 689 27 with with IN cord-005453-4057qib7 689 28 AML AML NNP cord-005453-4057qib7 689 29 where where WRB cord-005453-4057qib7 689 30 autologous autologous JJ cord-005453-4057qib7 689 31 stem stem NN cord-005453-4057qib7 689 32 cell cell NN cord-005453-4057qib7 689 33 transplantation transplantation NN cord-005453-4057qib7 689 34 was be VBD cord-005453-4057qib7 689 35 performed perform VBN cord-005453-4057qib7 689 36 in in IN cord-005453-4057qib7 689 37 the the DT cord-005453-4057qib7 689 38 period period NN cord-005453-4057qib7 689 39 from from IN cord-005453-4057qib7 689 40 2000 2000 CD cord-005453-4057qib7 689 41 till till IN cord-005453-4057qib7 689 42 2018 2018 CD cord-005453-4057qib7 689 43 . . . cord-005453-4057qib7 690 1 Our -PRON- PRP$ cord-005453-4057qib7 690 2 group group NN cord-005453-4057qib7 690 3 consisted consist VBD cord-005453-4057qib7 690 4 of of IN cord-005453-4057qib7 690 5 94 94 CD cord-005453-4057qib7 690 6 patients patient NNS cord-005453-4057qib7 690 7 ; ; : cord-005453-4057qib7 690 8 male male JJ cord-005453-4057qib7 690 9 patients patient NNS cord-005453-4057qib7 690 10 45 45 CD cord-005453-4057qib7 690 11 ( ( -LRB- cord-005453-4057qib7 690 12 47.8 47.8 CD cord-005453-4057qib7 690 13 % % NN cord-005453-4057qib7 690 14 ) ) -RRB- cord-005453-4057qib7 690 15 , , , cord-005453-4057qib7 690 16 female female JJ cord-005453-4057qib7 690 17 patients patient NNS cord-005453-4057qib7 690 18 49 49 CD cord-005453-4057qib7 690 19 ( ( -LRB- cord-005453-4057qib7 690 20 52.2 52.2 CD cord-005453-4057qib7 690 21 % % NN cord-005453-4057qib7 690 22 ) ) -RRB- cord-005453-4057qib7 690 23 . . . cord-005453-4057qib7 691 1 Median median JJ cord-005453-4057qib7 691 2 age age NN cord-005453-4057qib7 691 3 at at IN cord-005453-4057qib7 691 4 diagnosis diagnosis NN cord-005453-4057qib7 691 5 was be VBD cord-005453-4057qib7 691 6 44 44 CD cord-005453-4057qib7 691 7 years year NNS cord-005453-4057qib7 691 8 ( ( -LRB- cord-005453-4057qib7 691 9 16 16 CD cord-005453-4057qib7 691 10 - - SYM cord-005453-4057qib7 691 11 68 68 CD cord-005453-4057qib7 691 12 ) ) -RRB- cord-005453-4057qib7 691 13 . . . cord-005453-4057qib7 692 1 The the DT cord-005453-4057qib7 692 2 average average JJ cord-005453-4057qib7 692 3 period period NN cord-005453-4057qib7 692 4 from from IN cord-005453-4057qib7 692 5 time time NN cord-005453-4057qib7 692 6 of of IN cord-005453-4057qib7 692 7 diagnosis diagnosis NN cord-005453-4057qib7 692 8 to to IN cord-005453-4057qib7 692 9 autologous autologous JJ cord-005453-4057qib7 692 10 SCT SCT NNP cord-005453-4057qib7 692 11 was be VBD cord-005453-4057qib7 692 12 7.05 7.05 CD cord-005453-4057qib7 692 13 months month NNS cord-005453-4057qib7 692 14 . . . cord-005453-4057qib7 693 1 Results result NNS cord-005453-4057qib7 693 2 : : : cord-005453-4057qib7 694 1 In in IN cord-005453-4057qib7 694 2 the the DT cord-005453-4057qib7 694 3 majority majority NN cord-005453-4057qib7 694 4 of of IN cord-005453-4057qib7 694 5 our -PRON- PRP$ cord-005453-4057qib7 694 6 group group NN cord-005453-4057qib7 694 7 , , , cord-005453-4057qib7 694 8 we -PRON- PRP cord-005453-4057qib7 694 9 used use VBD cord-005453-4057qib7 694 10 myeloablative myeloablative NNP cord-005453-4057qib7 694 11 conditioning conditioning NN cord-005453-4057qib7 694 12 regimen regimen NN cord-005453-4057qib7 694 13 with with IN cord-005453-4057qib7 694 14 Busulphan Busulphan NNP cord-005453-4057qib7 694 15 - - HYPH cord-005453-4057qib7 694 16 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 694 17 , , , cord-005453-4057qib7 694 18 60 60 CD cord-005453-4057qib7 694 19 patients patient NNS cord-005453-4057qib7 694 20 ( ( -LRB- cord-005453-4057qib7 694 21 63.8 63.8 CD cord-005453-4057qib7 694 22 % % NN cord-005453-4057qib7 694 23 ) ) -RRB- cord-005453-4057qib7 694 24 , , , cord-005453-4057qib7 694 25 in in IN cord-005453-4057qib7 694 26 2 2 CD cord-005453-4057qib7 694 27 patients patient NNS cord-005453-4057qib7 694 28 ( ( -LRB- cord-005453-4057qib7 694 29 2.1 2.1 CD cord-005453-4057qib7 694 30 % % NN cord-005453-4057qib7 694 31 ) ) -RRB- cord-005453-4057qib7 694 32 we -PRON- PRP cord-005453-4057qib7 694 33 have have VBP cord-005453-4057qib7 694 34 added add VBN cord-005453-4057qib7 694 35 melphalan melphalan NNP cord-005453-4057qib7 694 36 to to IN cord-005453-4057qib7 694 37 Bu Bu NNP cord-005453-4057qib7 694 38 - - HYPH cord-005453-4057qib7 694 39 Cy Cy NNP cord-005453-4057qib7 694 40 conditioning conditioning NN cord-005453-4057qib7 694 41 , , , cord-005453-4057qib7 694 42 in in IN cord-005453-4057qib7 694 43 22 22 CD cord-005453-4057qib7 694 44 ( ( -LRB- cord-005453-4057qib7 694 45 23.4 23.4 CD cord-005453-4057qib7 694 46 % % NN cord-005453-4057qib7 694 47 ) ) -RRB- cord-005453-4057qib7 694 48 patients patient NNS cord-005453-4057qib7 694 49 we -PRON- PRP cord-005453-4057qib7 694 50 used use VBD cord-005453-4057qib7 694 51 BEAM beam NN cord-005453-4057qib7 694 52 conditioning conditioning NN cord-005453-4057qib7 694 53 and and CC cord-005453-4057qib7 694 54 in in IN cord-005453-4057qib7 694 55 the the DT cord-005453-4057qib7 694 56 rest rest NN cord-005453-4057qib7 694 57 , , , cord-005453-4057qib7 694 58 10 10 CD cord-005453-4057qib7 694 59 patients patient NNS cord-005453-4057qib7 694 60 ( ( -LRB- cord-005453-4057qib7 694 61 10.6 10.6 CD cord-005453-4057qib7 694 62 % % NN cord-005453-4057qib7 694 63 ) ) -RRB- cord-005453-4057qib7 694 64 we -PRON- PRP cord-005453-4057qib7 694 65 used use VBD cord-005453-4057qib7 694 66 BAM BAM NNP cord-005453-4057qib7 694 67 conditioning conditioning NN cord-005453-4057qib7 694 68 regimen regimen NN cord-005453-4057qib7 694 69 . . . cord-005453-4057qib7 695 1 As as IN cord-005453-4057qib7 695 2 auto auto NN cord-005453-4057qib7 695 3 graft graft NN cord-005453-4057qib7 695 4 we -PRON- PRP cord-005453-4057qib7 695 5 used use VBD cord-005453-4057qib7 695 6 peripheral peripheral JJ cord-005453-4057qib7 695 7 blood blood NN cord-005453-4057qib7 695 8 stem stem NN cord-005453-4057qib7 695 9 cells cell NNS cord-005453-4057qib7 695 10 ( ( -LRB- cord-005453-4057qib7 695 11 PBSC PBSC NNP cord-005453-4057qib7 695 12 ) ) -RRB- cord-005453-4057qib7 695 13 in in IN cord-005453-4057qib7 695 14 78 78 CD cord-005453-4057qib7 695 15 patients patient NNS cord-005453-4057qib7 695 16 ( ( -LRB- cord-005453-4057qib7 695 17 82.9 82.9 CD cord-005453-4057qib7 695 18 % % NN cord-005453-4057qib7 695 19 ) ) -RRB- cord-005453-4057qib7 695 20 , , , cord-005453-4057qib7 695 21 and and CC cord-005453-4057qib7 695 22 in in IN cord-005453-4057qib7 695 23 16 16 CD cord-005453-4057qib7 695 24 patients patient NNS cord-005453-4057qib7 695 25 ( ( -LRB- cord-005453-4057qib7 695 26 17.1 17.1 CD cord-005453-4057qib7 695 27 % % NN cord-005453-4057qib7 695 28 ) ) -RRB- cord-005453-4057qib7 695 29 we -PRON- PRP cord-005453-4057qib7 695 30 used use VBD cord-005453-4057qib7 695 31 bone bone NN cord-005453-4057qib7 695 32 marrow marrow NN cord-005453-4057qib7 695 33 . . . cord-005453-4057qib7 696 1 The the DT cord-005453-4057qib7 696 2 main main JJ cord-005453-4057qib7 696 3 mobilising mobilise VBG cord-005453-4057qib7 696 4 regimen regimen NN cord-005453-4057qib7 696 5 for for IN cord-005453-4057qib7 696 6 PBSC PBSC NNP cord-005453-4057qib7 696 7 was be VBD cord-005453-4057qib7 696 8 G G NNP cord-005453-4057qib7 696 9 - - HYPH cord-005453-4057qib7 696 10 CSF csf NN cord-005453-4057qib7 696 11 + + CC cord-005453-4057qib7 696 12 etoposide etoposide RB cord-005453-4057qib7 697 1 and and CC cord-005453-4057qib7 697 2 it -PRON- PRP cord-005453-4057qib7 697 3 was be VBD cord-005453-4057qib7 697 4 performed perform VBN cord-005453-4057qib7 697 5 in in IN cord-005453-4057qib7 697 6 44 44 CD cord-005453-4057qib7 697 7 patients patient NNS cord-005453-4057qib7 697 8 ( ( -LRB- cord-005453-4057qib7 697 9 46.8 46.8 CD cord-005453-4057qib7 697 10 % % NN cord-005453-4057qib7 697 11 ) ) -RRB- cord-005453-4057qib7 697 12 , , , cord-005453-4057qib7 697 13 and and CC cord-005453-4057qib7 697 14 in in IN cord-005453-4057qib7 697 15 the the DT cord-005453-4057qib7 697 16 remaining remain VBG cord-005453-4057qib7 697 17 34 34 CD cord-005453-4057qib7 697 18 patients patient NNS cord-005453-4057qib7 697 19 ( ( -LRB- cord-005453-4057qib7 697 20 36.1 36.1 CD cord-005453-4057qib7 697 21 % % NN cord-005453-4057qib7 697 22 ) ) -RRB- cord-005453-4057qib7 697 23 mobilising mobilising NN cord-005453-4057qib7 697 24 of of IN cord-005453-4057qib7 697 25 PBSC PBSC NNP cord-005453-4057qib7 697 26 was be VBD cord-005453-4057qib7 697 27 performed perform VBN cord-005453-4057qib7 697 28 only only RB cord-005453-4057qib7 697 29 with with IN cord-005453-4057qib7 697 30 G G NNP cord-005453-4057qib7 697 31 - - HYPH cord-005453-4057qib7 697 32 CSF CSF NNP cord-005453-4057qib7 697 33 . . . cord-005453-4057qib7 698 1 The the DT cord-005453-4057qib7 698 2 mean mean JJ cord-005453-4057qib7 698 3 number number NN cord-005453-4057qib7 698 4 od od NNP cord-005453-4057qib7 698 5 apheresis apheresis NN cord-005453-4057qib7 698 6 procedures procedure NNS cord-005453-4057qib7 698 7 done do VBN cord-005453-4057qib7 698 8 in in IN cord-005453-4057qib7 698 9 our -PRON- PRP$ cord-005453-4057qib7 698 10 group group NN cord-005453-4057qib7 698 11 was be VBD cord-005453-4057qib7 698 12 1.55 1.55 CD cord-005453-4057qib7 698 13 , , , cord-005453-4057qib7 698 14 and and CC cord-005453-4057qib7 698 15 the the DT cord-005453-4057qib7 698 16 mean mean JJ cord-005453-4057qib7 698 17 number number NN cord-005453-4057qib7 698 18 of of IN cord-005453-4057qib7 698 19 collected collect VBN cord-005453-4057qib7 698 20 mononuclear mononuclear JJ cord-005453-4057qib7 698 21 cells cell NNS cord-005453-4057qib7 698 22 was be VBD cord-005453-4057qib7 698 23 3.05x10 3.05x10 CD cord-005453-4057qib7 698 24 8 8 CD cord-005453-4057qib7 698 25 /kg /kg NN cord-005453-4057qib7 698 26 TT TT NNP cord-005453-4057qib7 698 27 . . . cord-005453-4057qib7 699 1 The the DT cord-005453-4057qib7 699 2 mean mean JJ cord-005453-4057qib7 699 3 time time NN cord-005453-4057qib7 699 4 to to IN cord-005453-4057qib7 699 5 engraftment engraftment NN cord-005453-4057qib7 699 6 was be VBD cord-005453-4057qib7 699 7 12.8 12.8 CD cord-005453-4057qib7 699 8 days day NNS cord-005453-4057qib7 699 9 ( ( -LRB- cord-005453-4057qib7 699 10 9 9 CD cord-005453-4057qib7 699 11 - - SYM cord-005453-4057qib7 699 12 23 23 CD cord-005453-4057qib7 699 13 ) ) -RRB- cord-005453-4057qib7 699 14 . . . cord-005453-4057qib7 700 1 The the DT cord-005453-4057qib7 700 2 transplant transplant NN cord-005453-4057qib7 700 3 related relate VBN cord-005453-4057qib7 700 4 mortality mortality NN cord-005453-4057qib7 700 5 ( ( -LRB- cord-005453-4057qib7 700 6 TRM TRM NNP cord-005453-4057qib7 700 7 ) ) -RRB- cord-005453-4057qib7 700 8 was be VBD cord-005453-4057qib7 700 9 2.1 2.1 CD cord-005453-4057qib7 700 10 % % NN cord-005453-4057qib7 700 11 . . . cord-005453-4057qib7 701 1 The the DT cord-005453-4057qib7 701 2 5 5 CD cord-005453-4057qib7 701 3 year year NN cord-005453-4057qib7 702 1 Overall Overall NNP cord-005453-4057qib7 702 2 Survival Survival NNP cord-005453-4057qib7 702 3 of of IN cord-005453-4057qib7 702 4 our -PRON- PRP$ cord-005453-4057qib7 702 5 patients patient NNS cord-005453-4057qib7 702 6 was be VBD cord-005453-4057qib7 702 7 46.7 46.7 CD cord-005453-4057qib7 702 8 patients patient NNS cord-005453-4057qib7 702 9 . . . cord-005453-4057qib7 703 1 The the DT cord-005453-4057qib7 703 2 main main JJ cord-005453-4057qib7 703 3 reason reason NN cord-005453-4057qib7 703 4 for for IN cord-005453-4057qib7 703 5 death death NN cord-005453-4057qib7 703 6 was be VBD cord-005453-4057qib7 703 7 relapse relapse NN cord-005453-4057qib7 703 8 of of IN cord-005453-4057qib7 703 9 the the DT cord-005453-4057qib7 703 10 primary primary JJ cord-005453-4057qib7 703 11 disease(73 disease(73 NNP cord-005453-4057qib7 703 12 % % NN cord-005453-4057qib7 703 13 ) ) -RRB- cord-005453-4057qib7 703 14 . . . cord-005453-4057qib7 704 1 20 20 CD cord-005453-4057qib7 704 2 patients patient NNS cord-005453-4057qib7 704 3 ( ( -LRB- cord-005453-4057qib7 704 4 21%)were 21%)were RB cord-005453-4057qib7 704 5 treated treat VBN cord-005453-4057qib7 704 6 with with IN cord-005453-4057qib7 704 7 salvage salvage NN cord-005453-4057qib7 704 8 chemotherapy chemotherapy NN cord-005453-4057qib7 704 9 regimen regimen NN cord-005453-4057qib7 704 10 ( ( -LRB- cord-005453-4057qib7 704 11 FLAG FLAG NNP cord-005453-4057qib7 704 12 - - HYPH cord-005453-4057qib7 704 13 Ida Ida NNP cord-005453-4057qib7 704 14 ) ) -RRB- cord-005453-4057qib7 704 15 because because IN cord-005453-4057qib7 704 16 with with IN cord-005453-4057qib7 704 17 the the DT cord-005453-4057qib7 704 18 standard standard JJ cord-005453-4057qib7 704 19 induction induction NN cord-005453-4057qib7 704 20 regimen regimen NN cord-005453-4057qib7 704 21 7 7 CD cord-005453-4057qib7 704 22 + + SYM cord-005453-4057qib7 704 23 3 3 CD cord-005453-4057qib7 704 24 there there EX cord-005453-4057qib7 704 25 was be VBD cord-005453-4057qib7 704 26 absence absence NN cord-005453-4057qib7 704 27 of of IN cord-005453-4057qib7 704 28 adequate adequate JJ cord-005453-4057qib7 704 29 therapeutic therapeutic JJ cord-005453-4057qib7 704 30 response response NN cord-005453-4057qib7 704 31 , , , cord-005453-4057qib7 704 32 or or CC cord-005453-4057qib7 704 33 predominantly predominantly RB cord-005453-4057qib7 704 34 no no DT cord-005453-4057qib7 704 35 Complete complete JJ cord-005453-4057qib7 704 36 remission remission NN cord-005453-4057qib7 704 37 was be VBD cord-005453-4057qib7 704 38 achieved achieve VBN cord-005453-4057qib7 704 39 . . . cord-005453-4057qib7 705 1 All all DT cord-005453-4057qib7 705 2 patients patient NNS cord-005453-4057qib7 705 3 were be VBD cord-005453-4057qib7 705 4 transplanted transplant VBN cord-005453-4057qib7 705 5 in in IN cord-005453-4057qib7 705 6 Complete complete JJ cord-005453-4057qib7 705 7 Remission remission NN cord-005453-4057qib7 705 8 Conclusions Conclusions NNPS cord-005453-4057qib7 705 9 : : : cord-005453-4057qib7 706 1 Autologous autologous JJ cord-005453-4057qib7 706 2 stem stem NN cord-005453-4057qib7 706 3 cell cell NN cord-005453-4057qib7 706 4 transplantation transplantation NN cord-005453-4057qib7 706 5 could could MD cord-005453-4057qib7 706 6 be be VB cord-005453-4057qib7 706 7 an an DT cord-005453-4057qib7 706 8 acceptable acceptable JJ cord-005453-4057qib7 706 9 therapeutic therapeutic JJ cord-005453-4057qib7 706 10 solution solution NN cord-005453-4057qib7 706 11 for for IN cord-005453-4057qib7 706 12 patients patient NNS cord-005453-4057qib7 706 13 with with IN cord-005453-4057qib7 706 14 AML AML NNP cord-005453-4057qib7 706 15 as as IN cord-005453-4057qib7 706 16 a a DT cord-005453-4057qib7 706 17 consolidation consolidation NN cord-005453-4057qib7 706 18 therapy therapy NN cord-005453-4057qib7 706 19 , , , cord-005453-4057qib7 706 20 where where WRB cord-005453-4057qib7 706 21 neither neither CC cord-005453-4057qib7 706 22 suitable suitable JJ cord-005453-4057qib7 706 23 compatible compatible JJ cord-005453-4057qib7 706 24 donor donor NN cord-005453-4057qib7 706 25 is be VBZ cord-005453-4057qib7 706 26 available available JJ cord-005453-4057qib7 706 27 nor nor CC cord-005453-4057qib7 706 28 allogeneic allogeneic IN cord-005453-4057qib7 706 29 stem stem NN cord-005453-4057qib7 706 30 cell cell NN cord-005453-4057qib7 706 31 transplantation transplantation NN cord-005453-4057qib7 706 32 could could MD cord-005453-4057qib7 706 33 not not RB cord-005453-4057qib7 706 34 be be VB cord-005453-4057qib7 706 35 performed perform VBN cord-005453-4057qib7 706 36 from from IN cord-005453-4057qib7 706 37 various various JJ cord-005453-4057qib7 706 38 reasons reason NNS cord-005453-4057qib7 706 39 depending depend VBG cord-005453-4057qib7 706 40 on on IN cord-005453-4057qib7 706 41 the the DT cord-005453-4057qib7 706 42 bone bone NN cord-005453-4057qib7 706 43 marrow marrow NN cord-005453-4057qib7 706 44 transplant transplant NN cord-005453-4057qib7 706 45 unit unit NN cord-005453-4057qib7 706 46 Disclosure Disclosure NNP cord-005453-4057qib7 706 47 : : : cord-005453-4057qib7 707 1 Nothing nothing NN cord-005453-4057qib7 707 2 to to TO cord-005453-4057qib7 707 3 declare declare VB cord-005453-4057qib7 707 4 P040 P040 : cord-005453-4057qib7 707 5 Prophylaxis Prophylaxis NNP cord-005453-4057qib7 707 6 DLI DLI NNP cord-005453-4057qib7 707 7 alone alone RB cord-005453-4057qib7 707 8 may may MD cord-005453-4057qib7 707 9 not not RB cord-005453-4057qib7 707 10 prevent prevent VB cord-005453-4057qib7 707 11 relapse relapse NN cord-005453-4057qib7 707 12 of of IN cord-005453-4057qib7 707 13 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 707 14 positive positive JJ cord-005453-4057qib7 707 15 AML AML NNP cord-005453-4057qib7 707 16 after after IN cord-005453-4057qib7 707 17 allogeneic allogeneic NN cord-005453-4057qib7 707 18 HCT HCT NNP cord-005453-4057qib7 707 19 Background background NN cord-005453-4057qib7 707 20 : : : cord-005453-4057qib7 708 1 One one CD cord-005453-4057qib7 708 2 of of IN cord-005453-4057qib7 708 3 the the DT cord-005453-4057qib7 708 4 most most RBS cord-005453-4057qib7 708 5 potent potent JJ cord-005453-4057qib7 708 6 prognostic prognostic JJ cord-005453-4057qib7 708 7 factors factor NNS cord-005453-4057qib7 708 8 affecting affect VBG cord-005453-4057qib7 708 9 outcomes outcome NNS cord-005453-4057qib7 708 10 in in IN cord-005453-4057qib7 708 11 AML AML NNP cord-005453-4057qib7 708 12 is be VBZ cord-005453-4057qib7 708 13 the the DT cord-005453-4057qib7 708 14 presence presence NN cord-005453-4057qib7 708 15 of of IN cord-005453-4057qib7 708 16 cytogenetic cytogenetic JJ cord-005453-4057qib7 708 17 and and CC cord-005453-4057qib7 708 18 molecular molecular JJ cord-005453-4057qib7 708 19 markers marker NNS cord-005453-4057qib7 708 20 which which WDT cord-005453-4057qib7 708 21 can can MD cord-005453-4057qib7 708 22 guide guide VB cord-005453-4057qib7 708 23 the the DT cord-005453-4057qib7 708 24 selection selection NN cord-005453-4057qib7 708 25 of of IN cord-005453-4057qib7 708 26 post post JJ cord-005453-4057qib7 708 27 - - JJ cord-005453-4057qib7 708 28 remission remission JJ cord-005453-4057qib7 708 29 therapies therapy NNS cord-005453-4057qib7 708 30 . . . cord-005453-4057qib7 709 1 Recently recently RB cord-005453-4057qib7 709 2 , , , cord-005453-4057qib7 709 3 favorable favorable JJ cord-005453-4057qib7 709 4 outcomes outcome NNS cord-005453-4057qib7 709 5 of of IN cord-005453-4057qib7 709 6 NPM1 NPM1 NNP cord-005453-4057qib7 709 7 wt wt NN cord-005453-4057qib7 709 8 /FLT3-ITD /FLT3-ITD NNP cord-005453-4057qib7 710 1 neg neg NNP cord-005453-4057qib7 710 2 /non /non NNP cord-005453-4057qib7 710 3 - - HYPH cord-005453-4057qib7 710 4 CEBPA CEBPA NNP cord-005453-4057qib7 710 5 dm dm NN cord-005453-4057qib7 710 6 group group NN cord-005453-4057qib7 710 7 after after IN cord-005453-4057qib7 710 8 allogeneic allogeneic JJ cord-005453-4057qib7 710 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 710 10 cell cell NN cord-005453-4057qib7 710 11 transplantation transplantation NN cord-005453-4057qib7 710 12 ( ( -LRB- cord-005453-4057qib7 710 13 allo allo NN cord-005453-4057qib7 710 14 - - HYPH cord-005453-4057qib7 710 15 HCT HCT NNP cord-005453-4057qib7 710 16 ) ) -RRB- cord-005453-4057qib7 710 17 have have VBP cord-005453-4057qib7 710 18 been be VBN cord-005453-4057qib7 710 19 reported report VBN cord-005453-4057qib7 710 20 , , , cord-005453-4057qib7 710 21 that that DT cord-005453-4057qib7 710 22 is be VBZ cord-005453-4057qib7 710 23 similar similar JJ cord-005453-4057qib7 710 24 to to IN cord-005453-4057qib7 710 25 those those DT cord-005453-4057qib7 710 26 of of IN cord-005453-4057qib7 710 27 favorable favorable JJ cord-005453-4057qib7 710 28 risk risk NN cord-005453-4057qib7 710 29 by by IN cord-005453-4057qib7 710 30 the the DT cord-005453-4057qib7 710 31 ELN ELN NNP cord-005453-4057qib7 710 32 risk risk NN cord-005453-4057qib7 710 33 classification classification NN cord-005453-4057qib7 710 34 . . . cord-005453-4057qib7 711 1 However however RB cord-005453-4057qib7 711 2 , , , cord-005453-4057qib7 711 3 the the DT cord-005453-4057qib7 711 4 role role NN cord-005453-4057qib7 711 5 of of IN cord-005453-4057qib7 711 6 allo allo NN cord-005453-4057qib7 711 7 - - HYPH cord-005453-4057qib7 711 8 HCT hct NN cord-005453-4057qib7 711 9 compared compare VBN cord-005453-4057qib7 711 10 to to IN cord-005453-4057qib7 711 11 consolidation consolidation NN cord-005453-4057qib7 711 12 chemotherapy chemotherapy NN cord-005453-4057qib7 711 13 has have VBZ cord-005453-4057qib7 711 14 not not RB cord-005453-4057qib7 711 15 yet yet RB cord-005453-4057qib7 711 16 been be VBN cord-005453-4057qib7 711 17 elucidated elucidate VBN cord-005453-4057qib7 711 18 . . . cord-005453-4057qib7 712 1 Methods method NNS cord-005453-4057qib7 712 2 : : : cord-005453-4057qib7 713 1 The the DT cord-005453-4057qib7 713 2 data datum NNS cord-005453-4057qib7 713 3 of of IN cord-005453-4057qib7 713 4 88 88 CD cord-005453-4057qib7 713 5 patients patient NNS cord-005453-4057qib7 713 6 who who WP cord-005453-4057qib7 713 7 were be VBD cord-005453-4057qib7 713 8 diagnosed diagnose VBN cord-005453-4057qib7 713 9 with with IN cord-005453-4057qib7 713 10 AML AML NNP cord-005453-4057qib7 713 11 and and CC cord-005453-4057qib7 713 12 received receive VBD cord-005453-4057qib7 713 13 intensive intensive JJ cord-005453-4057qib7 713 14 induction induction NN cord-005453-4057qib7 713 15 therapy therapy NN cord-005453-4057qib7 713 16 from from IN cord-005453-4057qib7 713 17 2015 2015 CD cord-005453-4057qib7 713 18 March March NNP cord-005453-4057qib7 713 19 to to IN cord-005453-4057qib7 713 20 2017 2017 CD cord-005453-4057qib7 713 21 July July NNP cord-005453-4057qib7 713 22 were be VBD cord-005453-4057qib7 713 23 included include VBN cord-005453-4057qib7 713 24 in in IN cord-005453-4057qib7 713 25 the the DT cord-005453-4057qib7 713 26 current current JJ cord-005453-4057qib7 713 27 study study NN cord-005453-4057qib7 713 28 . . . cord-005453-4057qib7 714 1 To to TO cord-005453-4057qib7 714 2 address address VB cord-005453-4057qib7 714 3 the the DT cord-005453-4057qib7 714 4 time time NN cord-005453-4057qib7 714 5 dependence dependence NN cord-005453-4057qib7 714 6 of of IN cord-005453-4057qib7 714 7 the the DT cord-005453-4057qib7 714 8 allo allo NN cord-005453-4057qib7 714 9 - - HYPH cord-005453-4057qib7 714 10 HCT HCT NNP cord-005453-4057qib7 714 11 , , , cord-005453-4057qib7 714 12 the the DT cord-005453-4057qib7 714 13 Simon Simon NNP cord-005453-4057qib7 714 14 and and CC cord-005453-4057qib7 714 15 Makuch Makuch NNP cord-005453-4057qib7 714 16 method method NN cord-005453-4057qib7 714 17 was be VBD cord-005453-4057qib7 714 18 used use VBN cord-005453-4057qib7 714 19 in in IN cord-005453-4057qib7 714 20 the the DT cord-005453-4057qib7 714 21 graphical graphical JJ cord-005453-4057qib7 714 22 representation representation NN cord-005453-4057qib7 714 23 and and CC cord-005453-4057qib7 714 24 the the DT cord-005453-4057qib7 714 25 Mantel Mantel NNP cord-005453-4057qib7 714 26 - - HYPH cord-005453-4057qib7 714 27 Byar Byar NNP cord-005453-4057qib7 714 28 test test NN cord-005453-4057qib7 714 29 and and CC cord-005453-4057qib7 714 30 Andersen Andersen NNP cord-005453-4057qib7 714 31 and and CC cord-005453-4057qib7 714 32 Gill Gill NNP cord-005453-4057qib7 714 33 methods method NNS cord-005453-4057qib7 714 34 for for IN cord-005453-4057qib7 714 35 identifying identify VBG cord-005453-4057qib7 714 36 risk risk NN cord-005453-4057qib7 714 37 factors factor NNS cord-005453-4057qib7 714 38 for for IN cord-005453-4057qib7 714 39 long long JJ cord-005453-4057qib7 714 40 - - HYPH cord-005453-4057qib7 714 41 term term NN cord-005453-4057qib7 714 42 survival survival NN cord-005453-4057qib7 714 43 . . . cord-005453-4057qib7 715 1 Results result NNS cord-005453-4057qib7 715 2 : : : cord-005453-4057qib7 716 1 Median median JJ cord-005453-4057qib7 716 2 age age NN cord-005453-4057qib7 716 3 of of IN cord-005453-4057qib7 716 4 the the DT cord-005453-4057qib7 716 5 patients patient NNS cord-005453-4057qib7 716 6 were be VBD cord-005453-4057qib7 716 7 53 53 CD cord-005453-4057qib7 716 8 years year NNS cord-005453-4057qib7 717 1 ( ( -LRB- cord-005453-4057qib7 717 2 range range NNP cord-005453-4057qib7 717 3 21 21 CD cord-005453-4057qib7 717 4 - - SYM cord-005453-4057qib7 717 5 69 69 CD cord-005453-4057qib7 717 6 ) ) -RRB- cord-005453-4057qib7 717 7 , , , cord-005453-4057qib7 717 8 and and CC cord-005453-4057qib7 717 9 49 49 CD cord-005453-4057qib7 717 10 patients patient NNS cord-005453-4057qib7 717 11 ( ( -LRB- cord-005453-4057qib7 717 12 56 56 CD cord-005453-4057qib7 717 13 % % NN cord-005453-4057qib7 717 14 ) ) -RRB- cord-005453-4057qib7 717 15 were be VBD cord-005453-4057qib7 717 16 male male JJ cord-005453-4057qib7 717 17 . . . cord-005453-4057qib7 718 1 NPM1 NPM1 NNP cord-005453-4057qib7 718 2 mutation mutation NN cord-005453-4057qib7 718 3 was be VBD cord-005453-4057qib7 718 4 detected detect VBN cord-005453-4057qib7 718 5 in in IN cord-005453-4057qib7 718 6 14 14 CD cord-005453-4057qib7 718 7 patients patient NNS cord-005453-4057qib7 718 8 ( ( -LRB- cord-005453-4057qib7 718 9 16 16 CD cord-005453-4057qib7 718 10 % % NN cord-005453-4057qib7 718 11 ) ) -RRB- cord-005453-4057qib7 718 12 , , , cord-005453-4057qib7 718 13 and and CC cord-005453-4057qib7 718 14 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 718 15 were be VBD cord-005453-4057qib7 718 16 none none NN cord-005453-4057qib7 718 17 , , , cord-005453-4057qib7 718 18 low low JJ cord-005453-4057qib7 718 19 , , , cord-005453-4057qib7 718 20 and and CC cord-005453-4057qib7 718 21 high high JJ cord-005453-4057qib7 718 22 ratio ratio NN cord-005453-4057qib7 718 23 in in IN cord-005453-4057qib7 718 24 69 69 CD cord-005453-4057qib7 718 25 patients patient NNS cord-005453-4057qib7 718 26 ( ( -LRB- cord-005453-4057qib7 718 27 78 78 CD cord-005453-4057qib7 718 28 % % NN cord-005453-4057qib7 718 29 ) ) -RRB- cord-005453-4057qib7 718 30 , , , cord-005453-4057qib7 718 31 9 9 CD cord-005453-4057qib7 718 32 ( ( -LRB- cord-005453-4057qib7 718 33 10 10 CD cord-005453-4057qib7 718 34 % % NN cord-005453-4057qib7 718 35 ) ) -RRB- cord-005453-4057qib7 718 36 , , , cord-005453-4057qib7 718 37 and and CC cord-005453-4057qib7 718 38 10 10 CD cord-005453-4057qib7 718 39 ( ( -LRB- cord-005453-4057qib7 718 40 12 12 CD cord-005453-4057qib7 718 41 % % NN cord-005453-4057qib7 718 42 ) ) -RRB- cord-005453-4057qib7 718 43 , , , cord-005453-4057qib7 718 44 respectively respectively RB cord-005453-4057qib7 718 45 . . . cord-005453-4057qib7 719 1 The the DT cord-005453-4057qib7 719 2 ELN ELN NNP cord-005453-4057qib7 719 3 risk risk NN cord-005453-4057qib7 719 4 classification classification NN cord-005453-4057qib7 719 5 divided divide VBD cord-005453-4057qib7 719 6 the the DT cord-005453-4057qib7 719 7 patients patient NNS cord-005453-4057qib7 719 8 into into IN cord-005453-4057qib7 719 9 favorable favorable JJ cord-005453-4057qib7 719 10 , , , cord-005453-4057qib7 719 11 intermediate intermediate JJ cord-005453-4057qib7 719 12 , , , cord-005453-4057qib7 719 13 and and CC cord-005453-4057qib7 719 14 adverse adverse JJ cord-005453-4057qib7 719 15 risk risk NN cord-005453-4057qib7 719 16 group group NN cord-005453-4057qib7 719 17 in in IN cord-005453-4057qib7 719 18 31 31 CD cord-005453-4057qib7 719 19 patients patient NNS cord-005453-4057qib7 719 20 ( ( -LRB- cord-005453-4057qib7 719 21 35 35 CD cord-005453-4057qib7 719 22 % % NN cord-005453-4057qib7 719 23 ) ) -RRB- cord-005453-4057qib7 719 24 , , , cord-005453-4057qib7 719 25 38 38 CD cord-005453-4057qib7 719 26 ( ( -LRB- cord-005453-4057qib7 719 27 43 43 CD cord-005453-4057qib7 719 28 % % NN cord-005453-4057qib7 719 29 ) ) -RRB- cord-005453-4057qib7 719 30 , , , cord-005453-4057qib7 719 31 and and CC cord-005453-4057qib7 719 32 19 19 CD cord-005453-4057qib7 719 33 ( ( -LRB- cord-005453-4057qib7 719 34 22 22 CD cord-005453-4057qib7 719 35 % % NN cord-005453-4057qib7 719 36 ) ) -RRB- cord-005453-4057qib7 719 37 , , , cord-005453-4057qib7 719 38 respectively respectively RB cord-005453-4057qib7 719 39 . . . cord-005453-4057qib7 720 1 NPN1 NPN1 NNP cord-005453-4057qib7 720 2 and and CC cord-005453-4057qib7 720 3 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 721 1 both both DT cord-005453-4057qib7 721 2 negative negative JJ cord-005453-4057qib7 721 3 group group NN cord-005453-4057qib7 721 4 included include VBD cord-005453-4057qib7 721 5 29 29 CD cord-005453-4057qib7 721 6 patients patient NNS cord-005453-4057qib7 721 7 ( ( -LRB- cord-005453-4057qib7 721 8 33 33 CD cord-005453-4057qib7 721 9 % % NN cord-005453-4057qib7 721 10 ) ) -RRB- cord-005453-4057qib7 721 11 . . . cord-005453-4057qib7 722 1 Allo Allo NNP cord-005453-4057qib7 722 2 - - HYPH cord-005453-4057qib7 722 3 HCT HCT NNP cord-005453-4057qib7 722 4 was be VBD cord-005453-4057qib7 722 5 performed perform VBN cord-005453-4057qib7 722 6 in in IN cord-005453-4057qib7 722 7 48 48 CD cord-005453-4057qib7 722 8 patients patient NNS cord-005453-4057qib7 722 9 ( ( -LRB- cord-005453-4057qib7 722 10 55 55 CD cord-005453-4057qib7 722 11 % % NN cord-005453-4057qib7 722 12 ) ) -RRB- cord-005453-4057qib7 722 13 . . . cord-005453-4057qib7 723 1 Overall overall RB cord-005453-4057qib7 723 2 , , , cord-005453-4057qib7 723 3 complete complete JJ cord-005453-4057qib7 723 4 response response NN cord-005453-4057qib7 723 5 ( ( -LRB- cord-005453-4057qib7 723 6 CR CR NNP cord-005453-4057qib7 723 7 ) ) -RRB- cord-005453-4057qib7 723 8 after after IN cord-005453-4057qib7 723 9 induction induction NN cord-005453-4057qib7 723 10 therapy therapy NN cord-005453-4057qib7 723 11 achieved achieve VBN cord-005453-4057qib7 723 12 in in IN cord-005453-4057qib7 723 13 63 63 CD cord-005453-4057qib7 723 14 patients patient NNS cord-005453-4057qib7 723 15 ( ( -LRB- cord-005453-4057qib7 723 16 72 72 CD cord-005453-4057qib7 723 17 % % NN cord-005453-4057qib7 723 18 ) ) -RRB- cord-005453-4057qib7 723 19 , , , cord-005453-4057qib7 723 20 and and CC cord-005453-4057qib7 723 21 7 7 CD cord-005453-4057qib7 723 22 patients patient NNS cord-005453-4057qib7 723 23 ( ( -LRB- cord-005453-4057qib7 723 24 8 8 CD cord-005453-4057qib7 723 25 % % NN cord-005453-4057qib7 723 26 ) ) -RRB- cord-005453-4057qib7 723 27 were be VBD cord-005453-4057qib7 723 28 primary primary JJ cord-005453-4057qib7 723 29 refractory refractory JJ cord-005453-4057qib7 723 30 disease disease NN cord-005453-4057qib7 723 31 . . . cord-005453-4057qib7 724 1 CR CR NNP cord-005453-4057qib7 724 2 rates rate NNS cord-005453-4057qib7 724 3 did do VBD cord-005453-4057qib7 724 4 not not RB cord-005453-4057qib7 724 5 differ differ VB cord-005453-4057qib7 724 6 between between IN cord-005453-4057qib7 724 7 NPM1 NPM1 NNP cord-005453-4057qib7 724 8 wt wt NN cord-005453-4057qib7 724 9 /FLT3-ITD /FLT3-ITD NNP cord-005453-4057qib7 724 10 negative negative JJ cord-005453-4057qib7 724 11 group group NN cord-005453-4057qib7 724 12 ( ( -LRB- cord-005453-4057qib7 724 13 n=17/29 n=17/29 UH cord-005453-4057qib7 724 14 , , , cord-005453-4057qib7 724 15 58.6 58.6 CD cord-005453-4057qib7 724 16 % % NN cord-005453-4057qib7 724 17 ) ) -RRB- cord-005453-4057qib7 724 18 and and CC cord-005453-4057qib7 724 19 other other JJ cord-005453-4057qib7 724 20 intermediate intermediate JJ cord-005453-4057qib7 724 21 risk risk NN cord-005453-4057qib7 724 22 group group NN cord-005453-4057qib7 724 23 ( ( -LRB- cord-005453-4057qib7 724 24 n=6/9 n=6/9 NNP cord-005453-4057qib7 724 25 , , , cord-005453-4057qib7 724 26 66.7 66.7 CD cord-005453-4057qib7 724 27 % % NN cord-005453-4057qib7 724 28 ; ; , cord-005453-4057qib7 724 29 p=0.967 p=0.967 NN cord-005453-4057qib7 724 30 ) ) -RRB- cord-005453-4057qib7 724 31 . . . cord-005453-4057qib7 725 1 With with IN cord-005453-4057qib7 725 2 median median JJ cord-005453-4057qib7 725 3 follow follow NN cord-005453-4057qib7 725 4 - - HYPH cord-005453-4057qib7 725 5 up up NN cord-005453-4057qib7 725 6 duration duration NN cord-005453-4057qib7 725 7 of of IN cord-005453-4057qib7 725 8 12.9 12.9 CD cord-005453-4057qib7 725 9 months month NNS cord-005453-4057qib7 725 10 ( ( -LRB- cord-005453-4057qib7 725 11 range range VBP cord-005453-4057qib7 725 12 1.3 1.3 CD cord-005453-4057qib7 725 13 - - HYPH cord-005453-4057qib7 725 14 39.0 39.0 CD cord-005453-4057qib7 725 15 months month NNS cord-005453-4057qib7 725 16 ) ) -RRB- cord-005453-4057qib7 725 17 , , , cord-005453-4057qib7 725 18 one one CD cord-005453-4057qib7 725 19 - - HYPH cord-005453-4057qib7 725 20 year year NN cord-005453-4057qib7 725 21 OS os NN cord-005453-4057qib7 725 22 rate rate NN cord-005453-4057qib7 725 23 were be VBD cord-005453-4057qib7 725 24 100 100 CD cord-005453-4057qib7 725 25 % % NN cord-005453-4057qib7 725 26 , , , cord-005453-4057qib7 725 27 83.5±6.9 83.5±6.9 CD cord-005453-4057qib7 725 28 % % NN cord-005453-4057qib7 725 29 , , , cord-005453-4057qib7 725 30 56.1±12.8 56.1±12.8 CD cord-005453-4057qib7 725 31 % % NN cord-005453-4057qib7 725 32 in in IN cord-005453-4057qib7 725 33 favorable favorable JJ cord-005453-4057qib7 725 34 , , , cord-005453-4057qib7 725 35 intermediate intermediate JJ cord-005453-4057qib7 725 36 , , , cord-005453-4057qib7 725 37 and and CC cord-005453-4057qib7 725 38 adverse adverse JJ cord-005453-4057qib7 725 39 risk risk NN cord-005453-4057qib7 725 40 group group NN cord-005453-4057qib7 725 41 ( ( -LRB- cord-005453-4057qib7 725 42 p p NN cord-005453-4057qib7 725 43 < < XX cord-005453-4057qib7 725 44 0.001 0.001 CD cord-005453-4057qib7 725 45 ) ) -RRB- cord-005453-4057qib7 725 46 . . . cord-005453-4057qib7 726 1 Among among IN cord-005453-4057qib7 726 2 intermediate intermediate JJ cord-005453-4057qib7 726 3 risk risk NN cord-005453-4057qib7 726 4 group group NN cord-005453-4057qib7 726 5 , , , cord-005453-4057qib7 726 6 OS OS NNP cord-005453-4057qib7 726 7 rate rate NN cord-005453-4057qib7 726 8 of of IN cord-005453-4057qib7 726 9 NPM1 NPM1 NNP cord-005453-4057qib7 726 10 wt wt NN cord-005453-4057qib7 726 11 /FLT3-ITD /FLT3-ITD NNP cord-005453-4057qib7 726 12 negative negative JJ cord-005453-4057qib7 726 13 group group NN cord-005453-4057qib7 726 14 was be VBD cord-005453-4057qib7 726 15 similar similar JJ cord-005453-4057qib7 726 16 to to IN cord-005453-4057qib7 726 17 other other JJ cord-005453-4057qib7 726 18 intermediate intermediate JJ cord-005453-4057qib7 726 19 risk risk NN cord-005453-4057qib7 726 20 ( ( -LRB- cord-005453-4057qib7 726 21 p=0.403 p=0.403 NNP cord-005453-4057qib7 726 22 ) ) -RRB- cord-005453-4057qib7 726 23 . . . cord-005453-4057qib7 727 1 Allo Allo NNP cord-005453-4057qib7 727 2 - - HYPH cord-005453-4057qib7 727 3 HCT HCT NNP cord-005453-4057qib7 727 4 was be VBD cord-005453-4057qib7 727 5 performed perform VBN cord-005453-4057qib7 727 6 in in IN cord-005453-4057qib7 727 7 11 11 CD cord-005453-4057qib7 727 8 patients patient NNS cord-005453-4057qib7 727 9 of of IN cord-005453-4057qib7 727 10 NPM1 NPM1 NNP cord-005453-4057qib7 727 11 wt wt NNP cord-005453-4057qib7 727 12 /FLT3-ITD /FLT3-ITD NNP cord-005453-4057qib7 727 13 negative negative JJ cord-005453-4057qib7 727 14 group group NN cord-005453-4057qib7 727 15 . . . cord-005453-4057qib7 728 1 One one CD cord-005453-4057qib7 728 2 - - HYPH cord-005453-4057qib7 728 3 year year NN cord-005453-4057qib7 728 4 OS os NN cord-005453-4057qib7 728 5 rates rate NNS cord-005453-4057qib7 728 6 did do VBD cord-005453-4057qib7 728 7 not not RB cord-005453-4057qib7 728 8 differ differ VB cord-005453-4057qib7 728 9 between between IN cord-005453-4057qib7 728 10 NPM1 NPM1 NNP cord-005453-4057qib7 728 11 wt wt NN cord-005453-4057qib7 728 12 /FLT3-ITD /FLT3-ITD NNP cord-005453-4057qib7 728 13 negative negative JJ cord-005453-4057qib7 728 14 and and CC cord-005453-4057qib7 728 15 other other JJ cord-005453-4057qib7 728 16 for for IN cord-005453-4057qib7 728 17 allogenic allogenic JJ cord-005453-4057qib7 728 18 hematopoietic hematopoietic JJ cord-005453-4057qib7 728 19 stem stem NN cord-005453-4057qib7 728 20 cell cell NN cord-005453-4057qib7 728 21 transplant transplant NN cord-005453-4057qib7 728 22 ( ( -LRB- cord-005453-4057qib7 728 23 allo allo NN cord-005453-4057qib7 728 24 - - HYPH cord-005453-4057qib7 728 25 HSCT HSCT NNP cord-005453-4057qib7 728 26 ) ) -RRB- cord-005453-4057qib7 728 27 , , , cord-005453-4057qib7 728 28 as as IN cord-005453-4057qib7 728 29 a a DT cord-005453-4057qib7 728 30 strategy strategy NN cord-005453-4057qib7 728 31 to to TO cord-005453-4057qib7 728 32 prolong prolong VB cord-005453-4057qib7 728 33 survival survival NN cord-005453-4057qib7 728 34 . . . cord-005453-4057qib7 729 1 Methods method NNS cord-005453-4057qib7 729 2 : : : cord-005453-4057qib7 729 3 Data datum NNS cord-005453-4057qib7 729 4 from from IN cord-005453-4057qib7 729 5 AML AML NNP cord-005453-4057qib7 729 6 pts pt NNS cord-005453-4057qib7 729 7 over over IN cord-005453-4057qib7 729 8 60 60 CD cord-005453-4057qib7 729 9 years year NNS cord-005453-4057qib7 729 10 , , , cord-005453-4057qib7 729 11 who who WP cord-005453-4057qib7 729 12 underwent undergo VBD cord-005453-4057qib7 729 13 RIC RIC NNP cord-005453-4057qib7 729 14 allo allo NNP cord-005453-4057qib7 729 15 - - HYPH cord-005453-4057qib7 729 16 HSCT HSCT NNP cord-005453-4057qib7 729 17 in in IN cord-005453-4057qib7 729 18 our -PRON- PRP$ cord-005453-4057qib7 729 19 institution institution NN cord-005453-4057qib7 729 20 between between IN cord-005453-4057qib7 729 21 September September NNP cord-005453-4057qib7 729 22 2011 2011 CD cord-005453-4057qib7 729 23 and and CC cord-005453-4057qib7 729 24 September September NNP cord-005453-4057qib7 729 25 2017 2017 CD cord-005453-4057qib7 729 26 , , , cord-005453-4057qib7 729 27 was be VBD cord-005453-4057qib7 729 28 retrospectively retrospectively RB cord-005453-4057qib7 729 29 collected collect VBN cord-005453-4057qib7 729 30 from from IN cord-005453-4057qib7 729 31 clinical clinical JJ cord-005453-4057qib7 729 32 files file NNS cord-005453-4057qib7 729 33 to to TO cord-005453-4057qib7 729 34 evaluate evaluate VB cord-005453-4057qib7 729 35 the the DT cord-005453-4057qib7 729 36 overall overall JJ cord-005453-4057qib7 729 37 survival survival NN cord-005453-4057qib7 729 38 ( ( -LRB- cord-005453-4057qib7 729 39 OS OS NNP cord-005453-4057qib7 729 40 ) ) -RRB- cord-005453-4057qib7 729 41 up up IN cord-005453-4057qib7 729 42 to to IN cord-005453-4057qib7 729 43 November November NNP cord-005453-4057qib7 729 44 2018 2018 CD cord-005453-4057qib7 729 45 . . . cord-005453-4057qib7 730 1 We -PRON- PRP cord-005453-4057qib7 730 2 calculated calculate VBD cord-005453-4057qib7 730 3 the the DT cord-005453-4057qib7 730 4 OS OS NNP cord-005453-4057qib7 730 5 using use VBG cord-005453-4057qib7 730 6 Kaplan Kaplan NNP cord-005453-4057qib7 730 7 - - HYPH cord-005453-4057qib7 730 8 Meyer Meyer NNP cord-005453-4057qib7 730 9 curves curve NNS cord-005453-4057qib7 730 10 . . . cord-005453-4057qib7 731 1 Results result NNS cord-005453-4057qib7 731 2 : : : cord-005453-4057qib7 732 1 We -PRON- PRP cord-005453-4057qib7 732 2 identified identify VBD cord-005453-4057qib7 732 3 15 15 CD cord-005453-4057qib7 732 4 pts pt NNS cord-005453-4057qib7 732 5 , , , cord-005453-4057qib7 732 6 median median JJ cord-005453-4057qib7 732 7 age age NN cord-005453-4057qib7 732 8 62 62 CD cord-005453-4057qib7 733 1 y.o y.o NNP cord-005453-4057qib7 733 2 . . . cord-005453-4057qib7 734 1 ( ( -LRB- cord-005453-4057qib7 734 2 60 60 CD cord-005453-4057qib7 734 3 - - SYM cord-005453-4057qib7 734 4 67 67 CD cord-005453-4057qib7 734 5 ) ) -RRB- cord-005453-4057qib7 734 6 and and CC cord-005453-4057qib7 735 1 median median JJ cord-005453-4057qib7 735 2 HTC HTC NNP cord-005453-4057qib7 735 3 - - : cord-005453-4057qib7 735 4 I -PRON- PRP cord-005453-4057qib7 735 5 score score VBP cord-005453-4057qib7 735 6 2 2 CD cord-005453-4057qib7 735 7 . . . cord-005453-4057qib7 736 1 The the DT cord-005453-4057qib7 736 2 median median JJ cord-005453-4057qib7 736 3 follow follow NN cord-005453-4057qib7 736 4 - - HYPH cord-005453-4057qib7 736 5 up up NN cord-005453-4057qib7 736 6 was be VBD cord-005453-4057qib7 736 7 25 25 CD cord-005453-4057qib7 736 8 months month NNS cord-005453-4057qib7 736 9 . . . cord-005453-4057qib7 737 1 One one CD cord-005453-4057qib7 737 2 patient patient NN cord-005453-4057qib7 737 3 ( ( -LRB- cord-005453-4057qib7 737 4 pt pt NN cord-005453-4057qib7 737 5 ) ) -RRB- cord-005453-4057qib7 737 6 had have VBD cord-005453-4057qib7 737 7 CML CML NNP cord-005453-4057qib7 737 8 blast blast NN cord-005453-4057qib7 737 9 crisis crisis NN cord-005453-4057qib7 737 10 and and CC cord-005453-4057qib7 737 11 was be VBD cord-005453-4057qib7 737 12 on on IN cord-005453-4057qib7 737 13 first first JJ cord-005453-4057qib7 737 14 major major JJ cord-005453-4057qib7 737 15 molecular molecular JJ cord-005453-4057qib7 737 16 remission remission NN cord-005453-4057qib7 737 17 . . . cord-005453-4057qib7 738 1 Of of IN cord-005453-4057qib7 738 2 the the DT cord-005453-4057qib7 738 3 remaining remain VBG cord-005453-4057qib7 738 4 14 14 CD cord-005453-4057qib7 738 5 AML AML NNP cord-005453-4057qib7 738 6 pts pt NNS cord-005453-4057qib7 738 7 , , , cord-005453-4057qib7 738 8 7 7 CD cord-005453-4057qib7 738 9 were be VBD cord-005453-4057qib7 738 10 in in IN cord-005453-4057qib7 738 11 1 1 CD cord-005453-4057qib7 738 12 st st NNP cord-005453-4057qib7 738 13 complete complete JJ cord-005453-4057qib7 738 14 remission remission NN cord-005453-4057qib7 738 15 ( ( -LRB- cord-005453-4057qib7 738 16 CR CR NNP cord-005453-4057qib7 738 17 ) ) -RRB- cord-005453-4057qib7 738 18 , , , cord-005453-4057qib7 738 19 4 4 CD cord-005453-4057qib7 738 20 in in IN cord-005453-4057qib7 738 21 2 2 CD cord-005453-4057qib7 738 22 nd nd NNP cord-005453-4057qib7 738 23 CR CR NNP cord-005453-4057qib7 738 24 and and CC cord-005453-4057qib7 738 25 1 1 CD cord-005453-4057qib7 738 26 with with IN cord-005453-4057qib7 738 27 progressive progressive JJ cord-005453-4057qib7 738 28 disease disease NN cord-005453-4057qib7 738 29 ( ( -LRB- cord-005453-4057qib7 738 30 PD PD NNP cord-005453-4057qib7 738 31 ) ) -RRB- cord-005453-4057qib7 738 32 ; ; : cord-005453-4057qib7 738 33 the the DT cord-005453-4057qib7 738 34 other other JJ cord-005453-4057qib7 738 35 2 2 CD cord-005453-4057qib7 738 36 pts pts NN cord-005453-4057qib7 738 37 could could MD cord-005453-4057qib7 738 38 be be VB cord-005453-4057qib7 738 39 classified classify VBN cord-005453-4057qib7 738 40 as as IN cord-005453-4057qib7 738 41 MDS MDS NNP cord-005453-4057qib7 738 42 according accord VBG cord-005453-4057qib7 738 43 to to IN cord-005453-4057qib7 738 44 2016 2016 CD cord-005453-4057qib7 739 1 WHO who WP cord-005453-4057qib7 739 2 diagnostic diagnostic JJ cord-005453-4057qib7 739 3 criteria criterion NNS cord-005453-4057qib7 739 4 and and CC cord-005453-4057qib7 739 5 were be VBD cord-005453-4057qib7 739 6 in in IN cord-005453-4057qib7 739 7 CR1 CR1 NNP cord-005453-4057qib7 739 8 . . . cord-005453-4057qib7 740 1 Donors donor NNS cord-005453-4057qib7 740 2 ( ( -LRB- cord-005453-4057qib7 740 3 D D NNP cord-005453-4057qib7 740 4 ) ) -RRB- cord-005453-4057qib7 740 5 were be VBD cord-005453-4057qib7 740 6 : : : cord-005453-4057qib7 740 7 3 3 CD cord-005453-4057qib7 740 8 matched match VBN cord-005453-4057qib7 740 9 unrelated unrelated JJ cord-005453-4057qib7 740 10 ( ( -LRB- cord-005453-4057qib7 740 11 MUD mud NN cord-005453-4057qib7 740 12 ) ) -RRB- cord-005453-4057qib7 740 13 , , , cord-005453-4057qib7 740 14 5 5 CD cord-005453-4057qib7 740 15 mismatched mismatched JJ cord-005453-4057qib7 740 16 unrelated unrelated JJ cord-005453-4057qib7 740 17 ( ( -LRB- cord-005453-4057qib7 740 18 MMUD MMUD NNP cord-005453-4057qib7 740 19 -9/10 -9/10 NN cord-005453-4057qib7 740 20 ) ) -RRB- cord-005453-4057qib7 740 21 , , , cord-005453-4057qib7 740 22 6 6 CD cord-005453-4057qib7 740 23 matched match VBN cord-005453-4057qib7 740 24 siblings sibling NNS cord-005453-4057qib7 740 25 and and CC cord-005453-4057qib7 740 26 1 1 CD cord-005453-4057qib7 740 27 haploidentical haploidentical JJ cord-005453-4057qib7 740 28 . . . cord-005453-4057qib7 741 1 Thirteen thirteen CD cord-005453-4057qib7 741 2 pts pt NNS cord-005453-4057qib7 741 3 were be VBD cord-005453-4057qib7 741 4 infused infuse VBN cord-005453-4057qib7 741 5 with with IN cord-005453-4057qib7 741 6 peripheral peripheral JJ cord-005453-4057qib7 741 7 blood blood NN cord-005453-4057qib7 741 8 HSC HSC NNP cord-005453-4057qib7 741 9 and and CC cord-005453-4057qib7 741 10 2 2 CD cord-005453-4057qib7 741 11 with with IN cord-005453-4057qib7 741 12 bone bone NN cord-005453-4057qib7 741 13 marrow marrow NN cord-005453-4057qib7 741 14 . . . cord-005453-4057qib7 742 1 Conditionings conditioning NNS cord-005453-4057qib7 742 2 were be VBD cord-005453-4057qib7 742 3 : : : cord-005453-4057qib7 742 4 FLUBCNUMEL flubcnumel VB cord-005453-4057qib7 742 5 in in IN cord-005453-4057qib7 742 6 5 5 CD cord-005453-4057qib7 742 7 unrelated unrelated JJ cord-005453-4057qib7 742 8 donor donor NN cord-005453-4057qib7 742 9 ( ( -LRB- cord-005453-4057qib7 742 10 UD UD NNP cord-005453-4057qib7 742 11 ) ) -RRB- cord-005453-4057qib7 742 12 pts pts NNP cord-005453-4057qib7 742 13 and and CC cord-005453-4057qib7 742 14 4 4 CD cord-005453-4057qib7 742 15 siblings sibling NNS cord-005453-4057qib7 742 16 , , , cord-005453-4057qib7 742 17 FLUMEL FLUMEL NNP cord-005453-4057qib7 742 18 in in IN cord-005453-4057qib7 742 19 1 1 CD cord-005453-4057qib7 742 20 UD UD NNP cord-005453-4057qib7 742 21 pt pt NN cord-005453-4057qib7 742 22 and and CC cord-005453-4057qib7 742 23 1 1 CD cord-005453-4057qib7 742 24 sibling sibling NN cord-005453-4057qib7 742 25 , , , cord-005453-4057qib7 742 26 FLUBU FLUBU NNP cord-005453-4057qib7 742 27 in in IN cord-005453-4057qib7 742 28 2 2 CD cord-005453-4057qib7 742 29 UD UD NNP cord-005453-4057qib7 742 30 pts pt NNS cord-005453-4057qib7 742 31 and and CC cord-005453-4057qib7 742 32 FLUTBI FLUTBI NNP cord-005453-4057qib7 742 33 2Gy 2gy NN cord-005453-4057qib7 742 34 in in IN cord-005453-4057qib7 742 35 1 1 CD cord-005453-4057qib7 742 36 sibling sibling NN cord-005453-4057qib7 742 37 and and CC cord-005453-4057qib7 742 38 in in IN cord-005453-4057qib7 742 39 the the DT cord-005453-4057qib7 742 40 haploidentical haploidentical JJ cord-005453-4057qib7 742 41 . . . cord-005453-4057qib7 743 1 Graft graft NN cord-005453-4057qib7 743 2 versus versus IN cord-005453-4057qib7 743 3 host host NN cord-005453-4057qib7 743 4 disease disease NN cord-005453-4057qib7 743 5 ( ( -LRB- cord-005453-4057qib7 743 6 GVHD GVHD NNP cord-005453-4057qib7 743 7 ) ) -RRB- cord-005453-4057qib7 743 8 prophylaxis prophylaxis NN cord-005453-4057qib7 743 9 was be VBD cord-005453-4057qib7 743 10 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 743 11 ( ( -LRB- cord-005453-4057qib7 743 12 TAC TAC NNP cord-005453-4057qib7 743 13 ) ) -RRB- cord-005453-4057qib7 743 14 + + CC cord-005453-4057qib7 743 15 MMF mmf NN cord-005453-4057qib7 743 16 in in IN cord-005453-4057qib7 743 17 5 5 CD cord-005453-4057qib7 743 18 UD UD NNP cord-005453-4057qib7 743 19 pts pt NNS cord-005453-4057qib7 743 20 and and CC cord-005453-4057qib7 743 21 1 1 CD cord-005453-4057qib7 743 22 sibling sibling NN cord-005453-4057qib7 743 23 , , , cord-005453-4057qib7 743 24 TAC TAC NNP cord-005453-4057qib7 743 25 + + CC cord-005453-4057qib7 743 26 MTX MTX NNP cord-005453-4057qib7 743 27 in in IN cord-005453-4057qib7 743 28 2 2 CD cord-005453-4057qib7 743 29 UD UD NNP cord-005453-4057qib7 743 30 pts pt NNS cord-005453-4057qib7 743 31 and and CC cord-005453-4057qib7 743 32 Cyclosporine Cyclosporine NNP cord-005453-4057qib7 743 33 ( ( -LRB- cord-005453-4057qib7 743 34 CyA CyA NNP cord-005453-4057qib7 743 35 ) ) -RRB- cord-005453-4057qib7 743 36 + + CC cord-005453-4057qib7 743 37 MMF mmf NN cord-005453-4057qib7 743 38 in in IN cord-005453-4057qib7 743 39 1 1 CD cord-005453-4057qib7 743 40 UD UD NNP cord-005453-4057qib7 743 41 pt pt NN cord-005453-4057qib7 743 42 and and CC cord-005453-4057qib7 743 43 5 5 CD cord-005453-4057qib7 743 44 siblings sibling NNS cord-005453-4057qib7 743 45 . . . cord-005453-4057qib7 744 1 All all DT cord-005453-4057qib7 744 2 MMUD MMUD NNP cord-005453-4057qib7 744 3 pts pts NNP cord-005453-4057qib7 744 4 had have VBD cord-005453-4057qib7 744 5 ATG ATG NNP cord-005453-4057qib7 744 6 . . . cord-005453-4057qib7 745 1 PTCy PTCy NNP cord-005453-4057qib7 745 2 was be VBD cord-005453-4057qib7 745 3 done do VBN cord-005453-4057qib7 745 4 in in IN cord-005453-4057qib7 745 5 the the DT cord-005453-4057qib7 745 6 haploidentical haploidentical JJ cord-005453-4057qib7 745 7 setting setting NN cord-005453-4057qib7 745 8 with with IN cord-005453-4057qib7 745 9 TAC TAC NNP cord-005453-4057qib7 745 10 + + CC cord-005453-4057qib7 745 11 MMF mmf NN cord-005453-4057qib7 745 12 . . . cord-005453-4057qib7 746 1 The the DT cord-005453-4057qib7 746 2 median median JJ cord-005453-4057qib7 746 3 time time NN cord-005453-4057qib7 746 4 to to IN cord-005453-4057qib7 746 5 neutrophil neutrophil NN cord-005453-4057qib7 746 6 and and CC cord-005453-4057qib7 746 7 platelet platelet NN cord-005453-4057qib7 746 8 engraftment engraftment NN cord-005453-4057qib7 746 9 for for IN cord-005453-4057qib7 746 10 the the DT cord-005453-4057qib7 746 11 whole whole JJ cord-005453-4057qib7 746 12 cohort cohort NN cord-005453-4057qib7 746 13 was be VBD cord-005453-4057qib7 746 14 14 14 CD cord-005453-4057qib7 746 15 and and CC cord-005453-4057qib7 746 16 11 11 CD cord-005453-4057qib7 746 17 days day NNS cord-005453-4057qib7 746 18 , , , cord-005453-4057qib7 746 19 respectively respectively RB cord-005453-4057qib7 746 20 . . . cord-005453-4057qib7 747 1 One one CD cord-005453-4057qib7 747 2 pt pt NN cord-005453-4057qib7 747 3 with with IN cord-005453-4057qib7 747 4 secondary secondary JJ cord-005453-4057qib7 747 5 engraftment engraftment NN cord-005453-4057qib7 747 6 failure failure NN cord-005453-4057qib7 747 7 required require VBN cord-005453-4057qib7 747 8 re re NN cord-005453-4057qib7 747 9 - - NN cord-005453-4057qib7 747 10 infusion infusion NN cord-005453-4057qib7 747 11 of of IN cord-005453-4057qib7 747 12 selected select VBN cord-005453-4057qib7 747 13 CD34 CD34 NNP cord-005453-4057qib7 747 14 + + CC cord-005453-4057qib7 747 15 cells cell NNS cord-005453-4057qib7 747 16 . . . cord-005453-4057qib7 748 1 Ten ten CD cord-005453-4057qib7 748 2 pts pt NNS cord-005453-4057qib7 748 3 presented present VBN cord-005453-4057qib7 748 4 with with IN cord-005453-4057qib7 748 5 mild mild JJ cord-005453-4057qib7 748 6 acute acute JJ cord-005453-4057qib7 748 7 skin skin NN cord-005453-4057qib7 748 8 GVHD GVHD NNP cord-005453-4057qib7 748 9 . . . cord-005453-4057qib7 749 1 Eleven eleven CD cord-005453-4057qib7 749 2 pts pt NNS cord-005453-4057qib7 749 3 had have VBD cord-005453-4057qib7 749 4 chronic chronic JJ cord-005453-4057qib7 749 5 GVHD GVHD NNP cord-005453-4057qib7 749 6 , , , cord-005453-4057qib7 749 7 2 2 CD cord-005453-4057qib7 749 8 classified classify VBN cord-005453-4057qib7 749 9 as as IN cord-005453-4057qib7 749 10 severe severe JJ cord-005453-4057qib7 749 11 ; ; : cord-005453-4057qib7 749 12 7 7 CD cord-005453-4057qib7 749 13 required require VBN cord-005453-4057qib7 749 14 systemic systemic JJ cord-005453-4057qib7 749 15 therapy therapy NN cord-005453-4057qib7 749 16 , , , cord-005453-4057qib7 749 17 5 5 CD cord-005453-4057qib7 749 18 of of IN cord-005453-4057qib7 749 19 those those DT cord-005453-4057qib7 749 20 beyond beyond IN cord-005453-4057qib7 749 21 1 1 CD cord-005453-4057qib7 749 22 year year NN cord-005453-4057qib7 749 23 . . . cord-005453-4057qib7 750 1 The the DT cord-005453-4057qib7 750 2 median median JJ cord-005453-4057qib7 750 3 time time NN cord-005453-4057qib7 750 4 on on IN cord-005453-4057qib7 750 5 immunosuppressants immunosuppressant NNS cord-005453-4057qib7 750 6 was be VBD cord-005453-4057qib7 750 7 404 404 CD cord-005453-4057qib7 750 8 days day NNS cord-005453-4057qib7 750 9 . . . cord-005453-4057qib7 751 1 At at IN cord-005453-4057qib7 751 2 2 2 CD cord-005453-4057qib7 751 3 years year NNS cord-005453-4057qib7 751 4 the the DT cord-005453-4057qib7 751 5 OS OS NNP cord-005453-4057qib7 751 6 was be VBD cord-005453-4057qib7 751 7 63.5 63.5 CD cord-005453-4057qib7 751 8 % % NN cord-005453-4057qib7 751 9 . . . cord-005453-4057qib7 752 1 There there EX cord-005453-4057qib7 752 2 were be VBD cord-005453-4057qib7 752 3 6 6 CD cord-005453-4057qib7 752 4 deaths death NNS cord-005453-4057qib7 752 5 : : : cord-005453-4057qib7 752 6 3 3 CD cord-005453-4057qib7 752 7 disease disease NN cord-005453-4057qib7 752 8 - - HYPH cord-005453-4057qib7 752 9 related relate VBN cord-005453-4057qib7 752 10 ( ( -LRB- cord-005453-4057qib7 752 11 2 2 CD cord-005453-4057qib7 752 12 relapses relapse NNS cord-005453-4057qib7 752 13 at at IN cord-005453-4057qib7 752 14 22 22 CD cord-005453-4057qib7 752 15 and and CC cord-005453-4057qib7 752 16 58 58 CD cord-005453-4057qib7 752 17 months month NNS cord-005453-4057qib7 752 18 and and CC cord-005453-4057qib7 752 19 1 1 CD cord-005453-4057qib7 752 20 PD pd NN cord-005453-4057qib7 752 21 at at IN cord-005453-4057qib7 752 22 d+30 d+30 NN cord-005453-4057qib7 752 23 ) ) -RRB- cord-005453-4057qib7 752 24 , , , cord-005453-4057qib7 752 25 2 2 CD cord-005453-4057qib7 752 26 infection infection NN cord-005453-4057qib7 752 27 complications complication NNS cord-005453-4057qib7 752 28 ( ( -LRB- cord-005453-4057qib7 752 29 2 2 CD cord-005453-4057qib7 752 30 septic septic JJ cord-005453-4057qib7 752 31 shock shock NN cord-005453-4057qib7 752 32 ) ) -RRB- cord-005453-4057qib7 752 33 and and CC cord-005453-4057qib7 752 34 1 1 CD cord-005453-4057qib7 752 35 to to IN cord-005453-4057qib7 752 36 secondary secondary JJ cord-005453-4057qib7 752 37 neoplasia neoplasia NNS cord-005453-4057qib7 752 38 . . . cord-005453-4057qib7 753 1 Other other JJ cord-005453-4057qib7 753 2 relevant relevant JJ cord-005453-4057qib7 753 3 complications complication NNS cord-005453-4057qib7 753 4 were be VBD cord-005453-4057qib7 753 5 hypoxemic hypoxemic JJ cord-005453-4057qib7 753 6 pneumonia pneumonia NN cord-005453-4057qib7 753 7 in in IN cord-005453-4057qib7 753 8 5 5 CD cord-005453-4057qib7 753 9 pts pt NNS cord-005453-4057qib7 753 10 , , , cord-005453-4057qib7 753 11 1 1 CD cord-005453-4057qib7 753 12 urinary urinary JJ cord-005453-4057qib7 753 13 sepsis sepsis NN cord-005453-4057qib7 753 14 , , , cord-005453-4057qib7 753 15 CMV CMV NNP cord-005453-4057qib7 753 16 and and CC cord-005453-4057qib7 753 17 EBV EBV NNP cord-005453-4057qib7 753 18 reactivation reactivation NN cord-005453-4057qib7 753 19 respectively respectively RB cord-005453-4057qib7 753 20 in in IN cord-005453-4057qib7 753 21 8 8 CD cord-005453-4057qib7 753 22 and and CC cord-005453-4057qib7 753 23 4 4 CD cord-005453-4057qib7 753 24 pts pt NNS cord-005453-4057qib7 753 25 ; ; , cord-005453-4057qib7 753 26 pulmonary pulmonary JJ cord-005453-4057qib7 753 27 and and CC cord-005453-4057qib7 753 28 renal renal JJ cord-005453-4057qib7 753 29 toxicity toxicity NN cord-005453-4057qib7 753 30 either either CC cord-005453-4057qib7 753 31 in in IN cord-005453-4057qib7 753 32 2 2 CD cord-005453-4057qib7 753 33 pts pts NN cord-005453-4057qib7 753 34 . . . cord-005453-4057qib7 754 1 At at IN cord-005453-4057qib7 754 2 end end NN cord-005453-4057qib7 754 3 of of IN cord-005453-4057qib7 754 4 follow follow NN cord-005453-4057qib7 754 5 - - HYPH cord-005453-4057qib7 754 6 up up NN cord-005453-4057qib7 754 7 , , , cord-005453-4057qib7 754 8 9 9 CD cord-005453-4057qib7 754 9 pts pt NNS cord-005453-4057qib7 754 10 were be VBD cord-005453-4057qib7 754 11 in in IN cord-005453-4057qib7 754 12 remission remission NN cord-005453-4057qib7 754 13 , , , cord-005453-4057qib7 754 14 8 8 CD cord-005453-4057qib7 754 15 without without IN cord-005453-4057qib7 754 16 negative negative JJ cord-005453-4057qib7 754 17 measurable measurable JJ cord-005453-4057qib7 754 18 residual residual JJ cord-005453-4057qib7 754 19 disease disease NN cord-005453-4057qib7 754 20 ( ( -LRB- cord-005453-4057qib7 754 21 MRD MRD NNP cord-005453-4057qib7 754 22 ) ) -RRB- cord-005453-4057qib7 754 23 , , , cord-005453-4057qib7 754 24 the the DT cord-005453-4057qib7 754 25 other other JJ cord-005453-4057qib7 754 26 MRD MRD NNP cord-005453-4057qib7 754 27 negative negative JJ cord-005453-4057qib7 754 28 pt pt NN cord-005453-4057qib7 754 29 died die VBD cord-005453-4057qib7 754 30 of of IN cord-005453-4057qib7 754 31 septic septic JJ cord-005453-4057qib7 754 32 shock shock NN cord-005453-4057qib7 754 33 and and CC cord-005453-4057qib7 754 34 severe severe JJ cord-005453-4057qib7 754 35 intestinal intestinal JJ cord-005453-4057qib7 754 36 GVHD GVHD NNP cord-005453-4057qib7 754 37 . . . cord-005453-4057qib7 755 1 Conclusions conclusion NNS cord-005453-4057qib7 755 2 : : : cord-005453-4057qib7 756 1 In in IN cord-005453-4057qib7 756 2 this this DT cord-005453-4057qib7 756 3 small small JJ cord-005453-4057qib7 756 4 cohort cohort NN cord-005453-4057qib7 756 5 , , , cord-005453-4057qib7 756 6 chronic chronic JJ cord-005453-4057qib7 756 7 GVHD GVHD NNP cord-005453-4057qib7 756 8 and and CC cord-005453-4057qib7 756 9 infectious infectious JJ cord-005453-4057qib7 756 10 complications complication NNS cord-005453-4057qib7 756 11 were be VBD cord-005453-4057qib7 756 12 major major JJ cord-005453-4057qib7 756 13 causes cause NNS cord-005453-4057qib7 756 14 of of IN cord-005453-4057qib7 756 15 morbidity morbidity NN cord-005453-4057qib7 756 16 but but CC cord-005453-4057qib7 756 17 there there EX cord-005453-4057qib7 756 18 were be VBD cord-005453-4057qib7 756 19 no no DT cord-005453-4057qib7 756 20 treatment treatment NN cord-005453-4057qib7 756 21 related relate VBN cord-005453-4057qib7 756 22 deaths death NNS cord-005453-4057qib7 756 23 before before IN cord-005453-4057qib7 756 24 d+100 d+100 NNS cord-005453-4057qib7 756 25 . . . cord-005453-4057qib7 757 1 Pts Pts NNP cord-005453-4057qib7 757 2 maintaining maintain VBG cord-005453-4057qib7 757 3 or or CC cord-005453-4057qib7 757 4 achieving achieve VBG cord-005453-4057qib7 757 5 MRD MRD NNP cord-005453-4057qib7 757 6 negativity negativity NN cord-005453-4057qib7 757 7 after after IN cord-005453-4057qib7 757 8 transplant transplant NN cord-005453-4057qib7 758 1 had have VBD cord-005453-4057qib7 758 2 better well JJR cord-005453-4057qib7 758 3 survival survival NN cord-005453-4057qib7 758 4 . . . cord-005453-4057qib7 759 1 Although although IN cord-005453-4057qib7 759 2 with with IN cord-005453-4057qib7 759 3 only only RB cord-005453-4057qib7 759 4 15 15 CD cord-005453-4057qib7 759 5 pts pt NNS cord-005453-4057qib7 759 6 , , , cord-005453-4057qib7 759 7 these these DT cord-005453-4057qib7 759 8 results result NNS cord-005453-4057qib7 759 9 suggest suggest VBP cord-005453-4057qib7 759 10 that that IN cord-005453-4057qib7 759 11 allo allo NN cord-005453-4057qib7 759 12 - - HYPH cord-005453-4057qib7 759 13 HSCT HSCT NNP cord-005453-4057qib7 759 14 is be VBZ cord-005453-4057qib7 759 15 feasible feasible JJ cord-005453-4057qib7 759 16 as as IN cord-005453-4057qib7 759 17 consolidation consolidation NN cord-005453-4057qib7 759 18 strategy strategy NN cord-005453-4057qib7 759 19 in in IN cord-005453-4057qib7 759 20 selected select VBN cord-005453-4057qib7 759 21 AML AML NNP cord-005453-4057qib7 759 22 pts pt NNS cord-005453-4057qib7 759 23 over over IN cord-005453-4057qib7 759 24 60 60 CD cord-005453-4057qib7 759 25 years year NNS cord-005453-4057qib7 759 26 . . . cord-005453-4057qib7 760 1 [ [ -LRB- cord-005453-4057qib7 760 2 [ [ -LRB- cord-005453-4057qib7 760 3 P043 P043 NNP cord-005453-4057qib7 760 4 Image image NN cord-005453-4057qib7 760 5 ] ] -RRB- cord-005453-4057qib7 760 6 1 1 CD cord-005453-4057qib7 760 7 . . . cord-005453-4057qib7 761 1 Overall Overall NNP cord-005453-4057qib7 761 2 Survival Survival NNP cord-005453-4057qib7 761 3 ] ] -RRB- cord-005453-4057qib7 761 4 Disclosure disclosure NN cord-005453-4057qib7 761 5 : : : cord-005453-4057qib7 761 6 Nothing nothing NN cord-005453-4057qib7 761 7 to to TO cord-005453-4057qib7 761 8 declare declare VB cord-005453-4057qib7 761 9 . . . cord-005453-4057qib7 762 1 Background background NN cord-005453-4057qib7 762 2 : : : cord-005453-4057qib7 763 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 763 2 stem stem NN cord-005453-4057qib7 763 3 cell cell NN cord-005453-4057qib7 763 4 transplantation transplantation NN cord-005453-4057qib7 763 5 ( ( -LRB- cord-005453-4057qib7 763 6 HSCT HSCT NNP cord-005453-4057qib7 763 7 ) ) -RRB- cord-005453-4057qib7 763 8 is be VBZ cord-005453-4057qib7 763 9 the the DT cord-005453-4057qib7 763 10 only only JJ cord-005453-4057qib7 763 11 curative curative JJ cord-005453-4057qib7 763 12 option option NN cord-005453-4057qib7 763 13 for for IN cord-005453-4057qib7 763 14 Fanconi Fanconi NNP cord-005453-4057qib7 763 15 anaemia anaemia NN cord-005453-4057qib7 763 16 ( ( -LRB- cord-005453-4057qib7 763 17 FA FA NNP cord-005453-4057qib7 763 18 ) ) -RRB- cord-005453-4057qib7 763 19 ; ; : cord-005453-4057qib7 763 20 an an DT cord-005453-4057qib7 763 21 inherited inherit VBN cord-005453-4057qib7 763 22 disorder disorder NN cord-005453-4057qib7 763 23 characterized characterize VBN cord-005453-4057qib7 763 24 by by IN cord-005453-4057qib7 763 25 congenital congenital JJ cord-005453-4057qib7 763 26 anomalies anomaly NNS cord-005453-4057qib7 763 27 , , , cord-005453-4057qib7 763 28 progressive progressive JJ cord-005453-4057qib7 763 29 bone bone NN cord-005453-4057qib7 763 30 marrow marrow NN cord-005453-4057qib7 763 31 failure failure NN cord-005453-4057qib7 763 32 ( ( -LRB- cord-005453-4057qib7 763 33 BMF BMF NNP cord-005453-4057qib7 763 34 ) ) -RRB- cord-005453-4057qib7 763 35 and and CC cord-005453-4057qib7 763 36 a a DT cord-005453-4057qib7 763 37 predisposition predisposition NN cord-005453-4057qib7 763 38 to to TO cord-005453-4057qib7 763 39 develop develop VB cord-005453-4057qib7 763 40 malignancies malignancy NNS cord-005453-4057qib7 763 41 . . . cord-005453-4057qib7 764 1 Methods method NNS cord-005453-4057qib7 765 1 : : : cord-005453-4057qib7 765 2 We -PRON- PRP cord-005453-4057qib7 765 3 retrospectively retrospectively RB cord-005453-4057qib7 765 4 analysed analyse VBD cord-005453-4057qib7 765 5 the the DT cord-005453-4057qib7 765 6 data datum NNS cord-005453-4057qib7 765 7 of of IN cord-005453-4057qib7 765 8 27 27 CD cord-005453-4057qib7 765 9 consecutive consecutive JJ cord-005453-4057qib7 765 10 patients patient NNS cord-005453-4057qib7 765 11 that that WDT cord-005453-4057qib7 765 12 underwent undergo VBD cord-005453-4057qib7 765 13 HSCT HSCT NNP cord-005453-4057qib7 765 14 at at IN cord-005453-4057qib7 765 15 this this DT cord-005453-4057qib7 765 16 centre centre NN cord-005453-4057qib7 765 17 from from IN cord-005453-4057qib7 765 18 2001 2001 CD cord-005453-4057qib7 765 19 till till IN cord-005453-4057qib7 765 20 June June NNP cord-005453-4057qib7 765 21 2018 2018 CD cord-005453-4057qib7 765 22 . . . cord-005453-4057qib7 766 1 The the DT cord-005453-4057qib7 766 2 data datum NNS cord-005453-4057qib7 766 3 was be VBD cord-005453-4057qib7 766 4 analysed analyse VBN cord-005453-4057qib7 766 5 for for IN cord-005453-4057qib7 766 6 variables variable NNS cord-005453-4057qib7 766 7 affecting affect VBG cord-005453-4057qib7 766 8 the the DT cord-005453-4057qib7 766 9 outcome outcome NN cord-005453-4057qib7 766 10 in in IN cord-005453-4057qib7 766 11 terms term NNS cord-005453-4057qib7 766 12 of of IN cord-005453-4057qib7 766 13 overall overall JJ cord-005453-4057qib7 766 14 survival survival NN cord-005453-4057qib7 766 15 ( ( -LRB- cord-005453-4057qib7 766 16 OS OS NNP cord-005453-4057qib7 766 17 ) ) -RRB- cord-005453-4057qib7 766 18 . . . cord-005453-4057qib7 767 1 Results result NNS cord-005453-4057qib7 767 2 : : : cord-005453-4057qib7 768 1 Median median JJ cord-005453-4057qib7 768 2 age age NN cord-005453-4057qib7 768 3 at at IN cord-005453-4057qib7 768 4 diagnosis diagnosis NN cord-005453-4057qib7 768 5 was be VBD cord-005453-4057qib7 768 6 10 10 CD cord-005453-4057qib7 768 7 years year NNS cord-005453-4057qib7 768 8 ( ( -LRB- cord-005453-4057qib7 768 9 2 2 CD cord-005453-4057qib7 768 10 - - SYM cord-005453-4057qib7 768 11 20 20 CD cord-005453-4057qib7 768 12 years year NNS cord-005453-4057qib7 768 13 ) ) -RRB- cord-005453-4057qib7 768 14 . . . cord-005453-4057qib7 769 1 Median median JJ cord-005453-4057qib7 769 2 age age NN cord-005453-4057qib7 769 3 at at IN cord-005453-4057qib7 769 4 transplant transplant NN cord-005453-4057qib7 769 5 was be VBD cord-005453-4057qib7 769 6 11.3 11.3 CD cord-005453-4057qib7 769 7 years year NNS cord-005453-4057qib7 769 8 ( ( -LRB- cord-005453-4057qib7 769 9 4 4 CD cord-005453-4057qib7 769 10 - - SYM cord-005453-4057qib7 769 11 25 25 CD cord-005453-4057qib7 769 12 yrs yr NNS cord-005453-4057qib7 769 13 ) ) -RRB- cord-005453-4057qib7 769 14 . . . cord-005453-4057qib7 770 1 All all DT cord-005453-4057qib7 770 2 patients patient NNS cord-005453-4057qib7 770 3 at at IN cord-005453-4057qib7 770 4 transplant transplant NN cord-005453-4057qib7 770 5 were be VBD cord-005453-4057qib7 770 6 in in IN cord-005453-4057qib7 770 7 aplastic aplastic NN cord-005453-4057qib7 770 8 phase phase NN cord-005453-4057qib7 770 9 . . . cord-005453-4057qib7 771 1 Male male JJ cord-005453-4057qib7 771 2 to to IN cord-005453-4057qib7 771 3 female female JJ cord-005453-4057qib7 771 4 ratio ratio NN cord-005453-4057qib7 771 5 was be VBD cord-005453-4057qib7 771 6 1.2:1 1.2:1 CD cord-005453-4057qib7 771 7 . . . cord-005453-4057qib7 772 1 Twenty twenty CD cord-005453-4057qib7 772 2 - - HYPH cord-005453-4057qib7 772 3 four four CD cord-005453-4057qib7 772 4 ( ( -LRB- cord-005453-4057qib7 772 5 88.9 88.9 CD cord-005453-4057qib7 772 6 % % NN cord-005453-4057qib7 772 7 ) ) -RRB- cord-005453-4057qib7 772 8 patients patient NNS cord-005453-4057qib7 772 9 had have VBD cord-005453-4057qib7 772 10 congenital congenital JJ cord-005453-4057qib7 772 11 anomalies anomaly NNS cord-005453-4057qib7 772 12 along along IN cord-005453-4057qib7 772 13 with with IN cord-005453-4057qib7 772 14 BMF BMF NNP cord-005453-4057qib7 772 15 while while IN cord-005453-4057qib7 772 16 3 3 CD cord-005453-4057qib7 772 17 were be VBD cord-005453-4057qib7 772 18 phenotypically phenotypically RB cord-005453-4057qib7 772 19 normal normal JJ cord-005453-4057qib7 772 20 . . . cord-005453-4057qib7 773 1 Twenty twenty CD cord-005453-4057qib7 773 2 - - HYPH cord-005453-4057qib7 773 3 three three CD cord-005453-4057qib7 773 4 ( ( -LRB- cord-005453-4057qib7 773 5 85.2 85.2 CD cord-005453-4057qib7 773 6 % % NN cord-005453-4057qib7 773 7 ) ) -RRB- cord-005453-4057qib7 773 8 patients patient NNS cord-005453-4057qib7 773 9 were be VBD cord-005453-4057qib7 773 10 10/10 10/10 CD cord-005453-4057qib7 773 11 HLA HLA NNP cord-005453-4057qib7 773 12 matched match VBN cord-005453-4057qib7 773 13 with with IN cord-005453-4057qib7 773 14 siblings sibling NNS cord-005453-4057qib7 773 15 , , , cord-005453-4057qib7 773 16 2 2 CD cord-005453-4057qib7 773 17 with with IN cord-005453-4057qib7 773 18 parents parent NNS cord-005453-4057qib7 773 19 and and CC cord-005453-4057qib7 773 20 2 2 CD cord-005453-4057qib7 773 21 with with IN cord-005453-4057qib7 773 22 cousins cousin NNS cord-005453-4057qib7 773 23 . . . cord-005453-4057qib7 774 1 Eleven eleven CD cord-005453-4057qib7 774 2 ( ( -LRB- cord-005453-4057qib7 774 3 40.7 40.7 CD cord-005453-4057qib7 774 4 % % NN cord-005453-4057qib7 774 5 ) ) -RRB- cord-005453-4057qib7 774 6 patients patient NNS cord-005453-4057qib7 774 7 had have VBD cord-005453-4057qib7 774 8 gender gender NN cord-005453-4057qib7 774 9 mismatch mismatch NN cord-005453-4057qib7 774 10 transplant transplant NN cord-005453-4057qib7 774 11 . . . cord-005453-4057qib7 775 1 Three three CD cord-005453-4057qib7 775 2 patients patient NNS cord-005453-4057qib7 775 3 had have VBD cord-005453-4057qib7 775 4 major major JJ cord-005453-4057qib7 775 5 and and CC cord-005453-4057qib7 775 6 6 6 CD cord-005453-4057qib7 775 7 had have VBD cord-005453-4057qib7 775 8 minor minor JJ cord-005453-4057qib7 775 9 ABO ABO NNP cord-005453-4057qib7 775 10 mismatch mismatch NN cord-005453-4057qib7 775 11 . . . cord-005453-4057qib7 776 1 Background background NN cord-005453-4057qib7 776 2 : : : cord-005453-4057qib7 777 1 Paroxysmal Paroxysmal NNP cord-005453-4057qib7 777 2 nocturnal nocturnal JJ cord-005453-4057qib7 777 3 hemoglobinuria hemoglobinuria NN cord-005453-4057qib7 777 4 ( ( -LRB- cord-005453-4057qib7 777 5 PNH PNH NNP cord-005453-4057qib7 777 6 ) ) -RRB- cord-005453-4057qib7 777 7 is be VBZ cord-005453-4057qib7 777 8 a a DT cord-005453-4057qib7 777 9 rare rare JJ cord-005453-4057qib7 777 10 clonal clonal JJ cord-005453-4057qib7 777 11 non non JJ cord-005453-4057qib7 777 12 - - JJ cord-005453-4057qib7 777 13 neoplastic neoplastic JJ cord-005453-4057qib7 777 14 hematopoietic hematopoietic JJ cord-005453-4057qib7 777 15 stem stem NN cord-005453-4057qib7 777 16 cell cell NN cord-005453-4057qib7 777 17 disease disease NN cord-005453-4057qib7 777 18 whose whose WP$ cord-005453-4057qib7 777 19 incidence incidence NN cord-005453-4057qib7 777 20 is be VBZ cord-005453-4057qib7 777 21 1.5 1.5 CD cord-005453-4057qib7 777 22 - - SYM cord-005453-4057qib7 777 23 2.9 2.9 CD cord-005453-4057qib7 777 24 cases case NNS cord-005453-4057qib7 777 25 / / SYM cord-005453-4057qib7 777 26 million million CD cord-005453-4057qib7 777 27 of of IN cord-005453-4057qib7 777 28 individuals individual NNS cord-005453-4057qib7 777 29 worldwide worldwide RB cord-005453-4057qib7 777 30 . . . cord-005453-4057qib7 778 1 Disease disease NN cord-005453-4057qib7 778 2 characteristics characteristic NNS cord-005453-4057qib7 778 3 and and CC cord-005453-4057qib7 778 4 natural natural JJ cord-005453-4057qib7 778 5 history history NN cord-005453-4057qib7 778 6 have have VBP cord-005453-4057qib7 778 7 been be VBN cord-005453-4057qib7 778 8 mostly mostly RB cord-005453-4057qib7 778 9 analyzed analyze VBN cord-005453-4057qib7 778 10 by by IN cord-005453-4057qib7 778 11 multicenter multicenter JJ cord-005453-4057qib7 778 12 , , , cord-005453-4057qib7 778 13 retrospective retrospective JJ cord-005453-4057qib7 778 14 studies study NNS cord-005453-4057qib7 778 15 , , , cord-005453-4057qib7 778 16 with with IN cord-005453-4057qib7 778 17 the the DT cord-005453-4057qib7 778 18 limit limit NN cord-005453-4057qib7 778 19 of of IN cord-005453-4057qib7 778 20 heterogeneous heterogeneous JJ cord-005453-4057qib7 778 21 approaches approach NNS cord-005453-4057qib7 778 22 . . . cord-005453-4057qib7 779 1 Herein herein RB cord-005453-4057qib7 779 2 we -PRON- PRP cord-005453-4057qib7 779 3 report report VBP cord-005453-4057qib7 779 4 the the DT cord-005453-4057qib7 779 5 incidence incidence NN cord-005453-4057qib7 779 6 of of IN cord-005453-4057qib7 779 7 severe severe JJ cord-005453-4057qib7 779 8 complications complication NNS cord-005453-4057qib7 779 9 and and CC cord-005453-4057qib7 779 10 outcome outcome NN cord-005453-4057qib7 779 11 in in IN cord-005453-4057qib7 779 12 a a DT cord-005453-4057qib7 779 13 real real JJ cord-005453-4057qib7 779 14 life life NN cord-005453-4057qib7 779 15 setting set VBG cord-005453-4057qib7 779 16 scenario scenario NN cord-005453-4057qib7 779 17 of of IN cord-005453-4057qib7 779 18 PNH PNH NNP cord-005453-4057qib7 779 19 patients patient NNS cord-005453-4057qib7 779 20 consecutively consecutively RB cord-005453-4057qib7 779 21 diagnosed diagnose VBD cord-005453-4057qib7 779 22 and and CC cord-005453-4057qib7 779 23 managed manage VBD cord-005453-4057qib7 779 24 at at IN cord-005453-4057qib7 779 25 our -PRON- PRP$ cord-005453-4057qib7 779 26 PNH PNH NNP cord-005453-4057qib7 779 27 referral referral NN cord-005453-4057qib7 779 28 Center Center NNP cord-005453-4057qib7 779 29 between between IN cord-005453-4057qib7 779 30 January January NNP cord-005453-4057qib7 779 31 1985 1985 CD cord-005453-4057qib7 779 32 and and CC cord-005453-4057qib7 779 33 June June NNP cord-005453-4057qib7 779 34 2018 2018 CD cord-005453-4057qib7 779 35 . . . cord-005453-4057qib7 780 1 Methods method NNS cord-005453-4057qib7 780 2 : : : cord-005453-4057qib7 780 3 Patients patient NNS cord-005453-4057qib7 780 4 received receive VBD cord-005453-4057qib7 780 5 a a DT cord-005453-4057qib7 780 6 homogeneous homogeneous JJ cord-005453-4057qib7 780 7 diagnostic diagnostic JJ cord-005453-4057qib7 780 8 and and CC cord-005453-4057qib7 780 9 treatment treatment NN cord-005453-4057qib7 780 10 approach approach NN cord-005453-4057qib7 780 11 according accord VBG cord-005453-4057qib7 780 12 to to IN cord-005453-4057qib7 780 13 the the DT cord-005453-4057qib7 780 14 period period NN cord-005453-4057qib7 780 15 of of IN cord-005453-4057qib7 780 16 observation observation NN cord-005453-4057qib7 780 17 ( ( -LRB- cord-005453-4057qib7 780 18 availability availability NN cord-005453-4057qib7 780 19 of of IN cord-005453-4057qib7 780 20 diagnostic diagnostic JJ cord-005453-4057qib7 780 21 tests test NNS cord-005453-4057qib7 780 22 and and CC cord-005453-4057qib7 780 23 eculizumab eculizumab NNS cord-005453-4057qib7 780 24 ) ) -RRB- cord-005453-4057qib7 780 25 . . . cord-005453-4057qib7 781 1 All all DT cord-005453-4057qib7 781 2 patients patient NNS cord-005453-4057qib7 781 3 treated treat VBN cord-005453-4057qib7 781 4 with with IN cord-005453-4057qib7 781 5 eculizumab eculizumab NNS cord-005453-4057qib7 781 6 received receive VBD cord-005453-4057qib7 781 7 vaccination vaccination NN cord-005453-4057qib7 781 8 with with IN cord-005453-4057qib7 781 9 conjugated conjugated JJ cord-005453-4057qib7 781 10 anti anti JJ cord-005453-4057qib7 781 11 - - JJ cord-005453-4057qib7 781 12 meningococcus meningococcus JJ cord-005453-4057qib7 781 13 ACWYserotypes acwyserotype NNS cord-005453-4057qib7 781 14 and and CC cord-005453-4057qib7 781 15 , , , cord-005453-4057qib7 781 16 since since IN cord-005453-4057qib7 781 17 2016 2016 CD cord-005453-4057qib7 781 18 , , , cord-005453-4057qib7 781 19 conjugated conjugate VBN cord-005453-4057qib7 781 20 anti anti JJ cord-005453-4057qib7 781 21 - - JJ cord-005453-4057qib7 781 22 meningococcus meningococcus JJ cord-005453-4057qib7 781 23 B b NN cord-005453-4057qib7 781 24 - - HYPH cord-005453-4057qib7 781 25 serotype serotype NN cord-005453-4057qib7 781 26 . . . cord-005453-4057qib7 782 1 In in IN cord-005453-4057qib7 782 2 the the DT cord-005453-4057qib7 782 3 event event NN cord-005453-4057qib7 782 4 of of IN cord-005453-4057qib7 782 5 any any DT cord-005453-4057qib7 782 6 complication complication NN cord-005453-4057qib7 782 7 , , , cord-005453-4057qib7 782 8 patients patient NNS cord-005453-4057qib7 782 9 could could MD cord-005453-4057qib7 782 10 refer refer VB cord-005453-4057qib7 782 11 to to IN cord-005453-4057qib7 782 12 dedicated dedicated JJ cord-005453-4057qib7 782 13 Hematology Hematology NNP cord-005453-4057qib7 782 14 Emergency Emergency NNP cord-005453-4057qib7 782 15 Rooms room NNS cord-005453-4057qib7 782 16 ( ( -LRB- cord-005453-4057qib7 782 17 ER ER NNP cord-005453-4057qib7 782 18 ) ) -RRB- cord-005453-4057qib7 782 19 24 24 CD cord-005453-4057qib7 782 20 hours hour NNS cord-005453-4057qib7 782 21 daily daily RB cord-005453-4057qib7 782 22 . . . cord-005453-4057qib7 783 1 The the DT cord-005453-4057qib7 783 2 occurrence occurrence NN cord-005453-4057qib7 783 3 of of IN cord-005453-4057qib7 783 4 renal renal JJ cord-005453-4057qib7 783 5 failure failure NN cord-005453-4057qib7 783 6 and and CC cord-005453-4057qib7 783 7 pulmonary pulmonary JJ cord-005453-4057qib7 783 8 hypertension hypertension NN cord-005453-4057qib7 783 9 was be VBD cord-005453-4057qib7 783 10 specifically specifically RB cord-005453-4057qib7 783 11 evaluated evaluate VBN cord-005453-4057qib7 783 12 . . . cord-005453-4057qib7 784 1 The the DT cord-005453-4057qib7 784 2 renal renal JJ cord-005453-4057qib7 784 3 function function NN cord-005453-4057qib7 784 4 was be VBD cord-005453-4057qib7 784 5 studied study VBN cord-005453-4057qib7 784 6 according accord VBG cord-005453-4057qib7 784 7 to to IN cord-005453-4057qib7 784 8 the the DT cord-005453-4057qib7 784 9 Cockcroft Cockcroft NNP cord-005453-4057qib7 784 10 - - HYPH cord-005453-4057qib7 784 11 Gault Gault NNP cord-005453-4057qib7 784 12 formula formula NN cord-005453-4057qib7 784 13 and and CC cord-005453-4057qib7 784 14 the the DT cord-005453-4057qib7 784 15 lung lung NN cord-005453-4057qib7 784 16 function function NN cord-005453-4057qib7 784 17 was be VBD cord-005453-4057qib7 784 18 prospectively prospectively RB cord-005453-4057qib7 784 19 monitored monitor VBN cord-005453-4057qib7 784 20 by by IN cord-005453-4057qib7 784 21 daytime daytime NN cord-005453-4057qib7 784 22 - - HYPH cord-005453-4057qib7 784 23 on on RP cord-005453-4057qib7 784 24 exertion exertion NN cord-005453-4057qib7 784 25 , , , cord-005453-4057qib7 784 26 nocturnal nocturnal JJ cord-005453-4057qib7 784 27 pulsoximetric pulsoximetric JJ cord-005453-4057qib7 784 28 profiles profile NNS cord-005453-4057qib7 784 29 and and CC cord-005453-4057qib7 784 30 complete complete VB cord-005453-4057qib7 784 31 spirometric spirometric JJ cord-005453-4057qib7 784 32 tests test NNS cord-005453-4057qib7 784 33 , , , cord-005453-4057qib7 784 34 with with IN cord-005453-4057qib7 784 35 DLCO DLCO NNP cord-005453-4057qib7 784 36 measurement measurement NN cord-005453-4057qib7 784 37 . . . cord-005453-4057qib7 785 1 Results result NNS cord-005453-4057qib7 785 2 : : : cord-005453-4057qib7 786 1 Overall,48 Overall,48 NNP cord-005453-4057qib7 786 2 PNH PNH NNP cord-005453-4057qib7 786 3 patients patient NNS cord-005453-4057qib7 786 4 , , , cord-005453-4057qib7 786 5 median median JJ cord-005453-4057qib7 786 6 age age NN cord-005453-4057qib7 786 7 36 36 CD cord-005453-4057qib7 786 8 years year NNS cord-005453-4057qib7 787 1 ( ( -LRB- cord-005453-4057qib7 787 2 range range NNP cord-005453-4057qib7 787 3 17 17 CD cord-005453-4057qib7 787 4 - - SYM cord-005453-4057qib7 787 5 84 84 CD cord-005453-4057qib7 787 6 ) ) -RRB- cord-005453-4057qib7 787 7 , , , cord-005453-4057qib7 787 8 were be VBD cord-005453-4057qib7 787 9 analyzed analyze VBN cord-005453-4057qib7 787 10 . . . cord-005453-4057qib7 788 1 At at IN cord-005453-4057qib7 788 2 diagnosis diagnosis NN cord-005453-4057qib7 788 3 , , , cord-005453-4057qib7 788 4 26 26 CD cord-005453-4057qib7 788 5 patients patient NNS cord-005453-4057qib7 788 6 had have VBD cord-005453-4057qib7 788 7 classic classic JJ cord-005453-4057qib7 788 8 PNH PNH NNP cord-005453-4057qib7 788 9 , , , cord-005453-4057qib7 788 10 19 19 CD cord-005453-4057qib7 788 11 aplastic aplastic NN cord-005453-4057qib7 788 12 PNH PNH NNP cord-005453-4057qib7 788 13 and and CC cord-005453-4057qib7 788 14 3 3 CD cord-005453-4057qib7 788 15 an an DT cord-005453-4057qib7 788 16 intermediate intermediate JJ cord-005453-4057qib7 788 17 form form NN cord-005453-4057qib7 788 18 . . . cord-005453-4057qib7 789 1 The the DT cord-005453-4057qib7 789 2 cumulative cumulative JJ cord-005453-4057qib7 789 3 incidences incidence NNS cord-005453-4057qib7 789 4 ( ( -LRB- cord-005453-4057qib7 789 5 CI CI NNP cord-005453-4057qib7 789 6 ) ) -RRB- cord-005453-4057qib7 789 7 of of IN cord-005453-4057qib7 789 8 thrombosis thrombosis NN cord-005453-4057qib7 789 9 , , , cord-005453-4057qib7 789 10 and and CC cord-005453-4057qib7 789 11 clonal clonal JJ cord-005453-4057qib7 789 12 hematologic hematologic JJ cord-005453-4057qib7 789 13 neoplasm neoplasm NN cord-005453-4057qib7 789 14 were be VBD cord-005453-4057qib7 789 15 29 29 CD cord-005453-4057qib7 789 16 % % NN cord-005453-4057qib7 789 17 , , , cord-005453-4057qib7 789 18 and and CC cord-005453-4057qib7 789 19 6 6 CD cord-005453-4057qib7 789 20 % % NN cord-005453-4057qib7 789 21 , , , cord-005453-4057qib7 789 22 respectively respectively RB cord-005453-4057qib7 789 23 . . . cord-005453-4057qib7 790 1 CI CI NNP cord-005453-4057qib7 790 2 of of IN cord-005453-4057qib7 790 3 pancytopenia pancytopenia NNP cord-005453-4057qib7 790 4 in in IN cord-005453-4057qib7 790 5 the the DT cord-005453-4057qib7 790 6 26 26 CD cord-005453-4057qib7 790 7 patients patient NNS cord-005453-4057qib7 790 8 with with IN cord-005453-4057qib7 790 9 classic classic JJ cord-005453-4057qib7 790 10 PNH PNH NNP cord-005453-4057qib7 790 11 was be VBD cord-005453-4057qib7 790 12 23 23 CD cord-005453-4057qib7 790 13 % % NN cord-005453-4057qib7 790 14 . . . cord-005453-4057qib7 791 1 One one CD cord-005453-4057qib7 791 2 patient patient NN cord-005453-4057qib7 791 3 showed show VBD cord-005453-4057qib7 791 4 a a DT cord-005453-4057qib7 791 5 spontaneous spontaneous JJ cord-005453-4057qib7 791 6 disappearance disappearance NN cord-005453-4057qib7 791 7 of of IN cord-005453-4057qib7 791 8 the the DT cord-005453-4057qib7 791 9 PNH PNH NNP cord-005453-4057qib7 791 10 clone clone NN cord-005453-4057qib7 791 11 . . . cord-005453-4057qib7 792 1 Since since IN cord-005453-4057qib7 792 2 2005 2005 CD cord-005453-4057qib7 792 3 , , , cord-005453-4057qib7 792 4 eculizumab eculizumab NNP cord-005453-4057qib7 792 5 was be VBD cord-005453-4057qib7 792 6 administered administer VBN cord-005453-4057qib7 792 7 in in IN cord-005453-4057qib7 792 8 28 28 CD cord-005453-4057qib7 792 9 patients patient NNS cord-005453-4057qib7 792 10 . . . cord-005453-4057qib7 793 1 After after IN cord-005453-4057qib7 793 2 eculizumab eculizumab NNP cord-005453-4057qib7 793 3 treatment treatment NN cord-005453-4057qib7 793 4 50 50 CD cord-005453-4057qib7 793 5 % % NN cord-005453-4057qib7 793 6 and and CC cord-005453-4057qib7 793 7 32 32 CD cord-005453-4057qib7 793 8 % % NN cord-005453-4057qib7 793 9 of of IN cord-005453-4057qib7 793 10 patients patient NNS cord-005453-4057qib7 793 11 reached reach VBD cord-005453-4057qib7 793 12 hemoglobin hemoglobin NN cord-005453-4057qib7 793 13 level level NN cord-005453-4057qib7 793 14 > > XX cord-005453-4057qib7 793 15 11g 11g CD cord-005453-4057qib7 793 16 / / SYM cord-005453-4057qib7 793 17 dL dl NN cord-005453-4057qib7 793 18 and and CC cord-005453-4057qib7 793 19 > > XX cord-005453-4057qib7 794 1 8 8 CD cord-005453-4057qib7 794 2 < < XX cord-005453-4057qib7 794 3 11g/ 11g/ CD cord-005453-4057qib7 794 4 dL dl NN cord-005453-4057qib7 794 5 without without IN cord-005453-4057qib7 794 6 transfusion transfusion NN cord-005453-4057qib7 794 7 , , , cord-005453-4057qib7 794 8 respectively respectively RB cord-005453-4057qib7 794 9 , , , cord-005453-4057qib7 794 10 while while IN cord-005453-4057qib7 794 11 18 18 CD cord-005453-4057qib7 794 12 % % NN cord-005453-4057qib7 794 13 were be VBD cord-005453-4057qib7 794 14 nonresponsive nonresponsive JJ cord-005453-4057qib7 794 15 . . . cord-005453-4057qib7 795 1 During during IN cord-005453-4057qib7 795 2 eculizumab eculizumab NNS cord-005453-4057qib7 795 3 treatment treatment NN cord-005453-4057qib7 795 4 no no DT cord-005453-4057qib7 795 5 thrombotic thrombotic JJ cord-005453-4057qib7 795 6 event event NN cord-005453-4057qib7 795 7 was be VBD cord-005453-4057qib7 795 8 observed observe VBN cord-005453-4057qib7 795 9 while while IN cord-005453-4057qib7 795 10 two two CD cord-005453-4057qib7 795 11 severe severe JJ cord-005453-4057qib7 795 12 infectious infectious JJ cord-005453-4057qib7 795 13 episodes episode NNS cord-005453-4057qib7 795 14 ( ( -LRB- cord-005453-4057qib7 795 15 respiratory respiratory JJ cord-005453-4057qib7 795 16 tract tract NN cord-005453-4057qib7 795 17 and and CC cord-005453-4057qib7 795 18 urinary urinary JJ cord-005453-4057qib7 795 19 tract tract NN cord-005453-4057qib7 795 20 infection infection NN cord-005453-4057qib7 795 21 ) ) -RRB- cord-005453-4057qib7 795 22 were be VBD cord-005453-4057qib7 795 23 observed observe VBN cord-005453-4057qib7 795 24 in in IN cord-005453-4057qib7 795 25 only only RB cord-005453-4057qib7 795 26 one one CD cord-005453-4057qib7 795 27 of of IN cord-005453-4057qib7 795 28 the the DT cord-005453-4057qib7 795 29 28 28 CD cord-005453-4057qib7 795 30 patients patient NNS cord-005453-4057qib7 795 31 . . . cord-005453-4057qib7 796 1 Extravascular extravascular JJ cord-005453-4057qib7 796 2 hemolysis hemolysis NN cord-005453-4057qib7 796 3 was be VBD cord-005453-4057qib7 796 4 demonstrated demonstrate VBN cord-005453-4057qib7 796 5 in in IN cord-005453-4057qib7 796 6 50 50 CD cord-005453-4057qib7 796 7 % % NN cord-005453-4057qib7 796 8 of of IN cord-005453-4057qib7 796 9 patients patient NNS cord-005453-4057qib7 796 10 . . . cord-005453-4057qib7 797 1 No no DT cord-005453-4057qib7 797 2 patient patient NN cord-005453-4057qib7 797 3 showed show VBD cord-005453-4057qib7 797 4 a a DT cord-005453-4057qib7 797 5 significant significant JJ cord-005453-4057qib7 797 6 reduction reduction NN cord-005453-4057qib7 797 7 of of IN cord-005453-4057qib7 797 8 the the DT cord-005453-4057qib7 797 9 renal renal JJ cord-005453-4057qib7 797 10 function function NN cord-005453-4057qib7 797 11 . . . cord-005453-4057qib7 798 1 Out out IN cord-005453-4057qib7 798 2 of of IN cord-005453-4057qib7 798 3 24 24 CD cord-005453-4057qib7 798 4 patients patient NNS cord-005453-4057qib7 798 5 prospectively prospectively RB cord-005453-4057qib7 798 6 monitored monitor VBN cord-005453-4057qib7 798 7 for for IN cord-005453-4057qib7 798 8 lung lung NN cord-005453-4057qib7 798 9 function function NN cord-005453-4057qib7 798 10 no no DT cord-005453-4057qib7 798 11 pathological pathological JJ cord-005453-4057qib7 798 12 alteration alteration NN cord-005453-4057qib7 798 13 in in IN cord-005453-4057qib7 798 14 any any DT cord-005453-4057qib7 798 15 diurnal diurnal JJ cord-005453-4057qib7 798 16 or or CC cord-005453-4057qib7 798 17 nocturnal nocturnal JJ cord-005453-4057qib7 798 18 pulseoximetric pulseoximetric NN cord-005453-4057qib7 798 19 test test NN cord-005453-4057qib7 798 20 was be VBD cord-005453-4057qib7 798 21 observed observe VBN cord-005453-4057qib7 798 22 . . . cord-005453-4057qib7 799 1 No no DT cord-005453-4057qib7 799 2 patient patient NN cord-005453-4057qib7 799 3 showed show VBD cord-005453-4057qib7 799 4 obstructive obstructive JJ cord-005453-4057qib7 799 5 or or CC cord-005453-4057qib7 799 6 restrictive restrictive JJ cord-005453-4057qib7 799 7 ventilatory ventilatory JJ cord-005453-4057qib7 799 8 deficiency deficiency NN cord-005453-4057qib7 799 9 , , , cord-005453-4057qib7 799 10 nor nor CC cord-005453-4057qib7 799 11 reduced reduce VBN cord-005453-4057qib7 799 12 DLCO DLCO NNP cord-005453-4057qib7 799 13 values value NNS cord-005453-4057qib7 799 14 . . . cord-005453-4057qib7 800 1 30-years 30-years CD cord-005453-4057qib7 800 2 overall overall JJ cord-005453-4057qib7 800 3 survival survival NN cord-005453-4057qib7 800 4 ( ( -LRB- cord-005453-4057qib7 800 5 OS OS NNP cord-005453-4057qib7 800 6 ) ) -RRB- cord-005453-4057qib7 800 7 was be VBD cord-005453-4057qib7 800 8 90 90 CD cord-005453-4057qib7 800 9 % % NN cord-005453-4057qib7 800 10 ( ( -LRB- cord-005453-4057qib7 800 11 4 4 CD cord-005453-4057qib7 800 12 patients patient NNS cord-005453-4057qib7 800 13 who who WP cord-005453-4057qib7 800 14 died die VBD cord-005453-4057qib7 800 15 for for IN cord-005453-4057qib7 800 16 non non JJ cord-005453-4057qib7 800 17 - - JJ cord-005453-4057qib7 800 18 PNH PNH NNP cord-005453-4057qib7 800 19 related related JJ cord-005453-4057qib7 800 20 reasons reason NNS cord-005453-4057qib7 800 21 were be VBD cord-005453-4057qib7 800 22 censored censor VBN cord-005453-4057qib7 800 23 at at IN cord-005453-4057qib7 800 24 the the DT cord-005453-4057qib7 800 25 last last JJ cord-005453-4057qib7 800 26 follow follow NN cord-005453-4057qib7 800 27 - - HYPH cord-005453-4057qib7 800 28 up).A up).a NN cord-005453-4057qib7 800 29 better well JJR cord-005453-4057qib7 800 30 OS OS NNP cord-005453-4057qib7 800 31 , , , cord-005453-4057qib7 800 32 even even RB cord-005453-4057qib7 800 33 if if IN cord-005453-4057qib7 800 34 not not RB cord-005453-4057qib7 800 35 statistically statistically RB cord-005453-4057qib7 800 36 significant significant JJ cord-005453-4057qib7 800 37 , , , cord-005453-4057qib7 800 38 was be VBD cord-005453-4057qib7 800 39 associated associate VBN cord-005453-4057qib7 800 40 to to IN cord-005453-4057qib7 800 41 the the DT cord-005453-4057qib7 800 42 absence absence NN cord-005453-4057qib7 800 43 of of IN cord-005453-4057qib7 800 44 thrombotic thrombotic JJ cord-005453-4057qib7 800 45 events event NNS cord-005453-4057qib7 800 46 ( ( -LRB- cord-005453-4057qib7 800 47 90%vs70 90%vs70 CD cord-005453-4057qib7 800 48 % % NN cord-005453-4057qib7 800 49 ) ) -RRB- cord-005453-4057qib7 800 50 , , , cord-005453-4057qib7 800 51 and and CC cord-005453-4057qib7 800 52 the the DT cord-005453-4057qib7 800 53 period period NN cord-005453-4057qib7 800 54 of of IN cord-005453-4057qib7 800 55 diagnosis diagnosis NN cord-005453-4057qib7 800 56 ( ( -LRB- cord-005453-4057qib7 800 57 100 100 CD cord-005453-4057qib7 800 58 % % NN cord-005453-4057qib7 800 59 in in IN cord-005453-4057qib7 800 60 2006 2006 CD cord-005453-4057qib7 800 61 - - SYM cord-005453-4057qib7 800 62 2018 2018 CD cord-005453-4057qib7 800 63 , , , cord-005453-4057qib7 800 64 91 91 CD cord-005453-4057qib7 800 65 % % NN cord-005453-4057qib7 800 66 in in IN cord-005453-4057qib7 800 67 1996 1996 CD cord-005453-4057qib7 800 68 - - SYM cord-005453-4057qib7 800 69 2005 2005 CD cord-005453-4057qib7 800 70 , , , cord-005453-4057qib7 800 71 75 75 CD cord-005453-4057qib7 800 72 % % NN cord-005453-4057qib7 800 73 in in IN cord-005453-4057qib7 800 74 1985 1985 CD cord-005453-4057qib7 800 75 - - SYM cord-005453-4057qib7 800 76 1995 1995 CD cord-005453-4057qib7 800 77 ) ) -RRB- cord-005453-4057qib7 800 78 . . . cord-005453-4057qib7 801 1 Conclusions conclusion NNS cord-005453-4057qib7 801 2 : : : cord-005453-4057qib7 802 1 Our -PRON- PRP$ cord-005453-4057qib7 802 2 study study NN cord-005453-4057qib7 802 3 reports report VBZ cord-005453-4057qib7 802 4 a a DT cord-005453-4057qib7 802 5 better well JJR cord-005453-4057qib7 802 6 OS os NN cord-005453-4057qib7 802 7 and and CC cord-005453-4057qib7 802 8 lower low JJR cord-005453-4057qib7 802 9 rate rate NN cord-005453-4057qib7 802 10 of of IN cord-005453-4057qib7 802 11 severe severe JJ cord-005453-4057qib7 802 12 complications complication NNS cord-005453-4057qib7 802 13 in in IN cord-005453-4057qib7 802 14 PNH PNH NNP cord-005453-4057qib7 802 15 compared compare VBN cord-005453-4057qib7 802 16 to to IN cord-005453-4057qib7 802 17 previous previous JJ cord-005453-4057qib7 802 18 experiences experience NNS cord-005453-4057qib7 802 19 . . . cord-005453-4057qib7 803 1 Although although IN cord-005453-4057qib7 803 2 renal renal JJ cord-005453-4057qib7 803 3 failure failure NN cord-005453-4057qib7 803 4 and and CC cord-005453-4057qib7 803 5 lung lung NN cord-005453-4057qib7 803 6 hypertension hypertension NN cord-005453-4057qib7 803 7 have have VBP cord-005453-4057qib7 803 8 been be VBN cord-005453-4057qib7 803 9 reported report VBN cord-005453-4057qib7 803 10 by by IN cord-005453-4057qib7 803 11 other other JJ cord-005453-4057qib7 803 12 groups group NNS cord-005453-4057qib7 803 13 , , , cord-005453-4057qib7 803 14 we -PRON- PRP cord-005453-4057qib7 803 15 did do VBD cord-005453-4057qib7 803 16 not not RB cord-005453-4057qib7 803 17 observe observe VB cord-005453-4057qib7 803 18 these these DT cord-005453-4057qib7 803 19 complications complication NNS cord-005453-4057qib7 803 20 along along IN cord-005453-4057qib7 803 21 a a DT cord-005453-4057qib7 803 22 prolonged prolong VBN cord-005453-4057qib7 803 23 follow follow NN cord-005453-4057qib7 803 24 - - HYPH cord-005453-4057qib7 803 25 up up NN cord-005453-4057qib7 803 26 . . . cord-005453-4057qib7 804 1 We -PRON- PRP cord-005453-4057qib7 804 2 can can MD cord-005453-4057qib7 804 3 assume assume VB cord-005453-4057qib7 804 4 that that IN cord-005453-4057qib7 804 5 the the DT cord-005453-4057qib7 804 6 availability availability NN cord-005453-4057qib7 804 7 of of IN cord-005453-4057qib7 804 8 a a DT cord-005453-4057qib7 804 9 dedicated dedicated JJ cord-005453-4057qib7 804 10 ER ER NNP cord-005453-4057qib7 804 11 service service NN cord-005453-4057qib7 804 12 enabled enable VBD cord-005453-4057qib7 804 13 an an DT cord-005453-4057qib7 804 14 early early JJ cord-005453-4057qib7 804 15 diagnosis diagnosis NN cord-005453-4057qib7 804 16 and and CC cord-005453-4057qib7 804 17 prompt prompt JJ cord-005453-4057qib7 804 18 treatment treatment NN cord-005453-4057qib7 804 19 in in IN cord-005453-4057qib7 804 20 case case NN cord-005453-4057qib7 804 21 of of IN cord-005453-4057qib7 804 22 hemoglobinuria hemoglobinuria NNP cord-005453-4057qib7 804 23 crises crisis NNS cord-005453-4057qib7 804 24 ( ( -LRB- cord-005453-4057qib7 804 25 reducing reduce VBG cord-005453-4057qib7 804 26 the the DT cord-005453-4057qib7 804 27 risk risk NN cord-005453-4057qib7 804 28 or or CC cord-005453-4057qib7 804 29 organ organ NN cord-005453-4057qib7 804 30 damage damage NN cord-005453-4057qib7 804 31 ) ) -RRB- cord-005453-4057qib7 804 32 or or CC cord-005453-4057qib7 804 33 other other JJ cord-005453-4057qib7 804 34 complications complication NNS cord-005453-4057qib7 804 35 . . . cord-005453-4057qib7 805 1 The the DT cord-005453-4057qib7 805 2 use use NN cord-005453-4057qib7 805 3 of of IN cord-005453-4057qib7 805 4 eculizumab eculizumab NNS cord-005453-4057qib7 805 5 , , , cord-005453-4057qib7 805 6 together together RB cord-005453-4057qib7 805 7 with with IN cord-005453-4057qib7 805 8 improved improved JJ cord-005453-4057qib7 805 9 supportive supportive JJ cord-005453-4057qib7 805 10 approaches approach NNS cord-005453-4057qib7 805 11 , , , cord-005453-4057qib7 805 12 presumably presumably RB cord-005453-4057qib7 805 13 accounts account VBZ cord-005453-4057qib7 805 14 for for IN cord-005453-4057qib7 805 15 the the DT cord-005453-4057qib7 805 16 trend trend NN cord-005453-4057qib7 805 17 towards towards IN cord-005453-4057qib7 805 18 a a DT cord-005453-4057qib7 805 19 better well JJR cord-005453-4057qib7 805 20 survival survival NN cord-005453-4057qib7 805 21 witnessed witness VBN cord-005453-4057qib7 805 22 over over IN cord-005453-4057qib7 805 23 the the DT cord-005453-4057qib7 805 24 last last JJ cord-005453-4057qib7 805 25 decade decade NN cord-005453-4057qib7 805 26 in in IN cord-005453-4057qib7 805 27 the the DT cord-005453-4057qib7 805 28 management management NN cord-005453-4057qib7 805 29 of of IN cord-005453-4057qib7 805 30 PNH PNH NNP cord-005453-4057qib7 805 31 patients patient NNS cord-005453-4057qib7 805 32 . . . cord-005453-4057qib7 806 1 Disclosure disclosure NN cord-005453-4057qib7 806 2 : : : cord-005453-4057qib7 806 3 Nothing nothing NN cord-005453-4057qib7 806 4 to to TO cord-005453-4057qib7 806 5 declare declare VB cord-005453-4057qib7 806 6 Haploidentical Haploidentical NNP cord-005453-4057qib7 806 7 and and CC cord-005453-4057qib7 806 8 unrelated unrelated JJ cord-005453-4057qib7 806 9 allogeneic allogeneic IN cord-005453-4057qib7 806 10 stem stem NN cord-005453-4057qib7 806 11 cell cell NN cord-005453-4057qib7 806 12 transplantation transplantation NN cord-005453-4057qib7 806 13 in in IN cord-005453-4057qib7 806 14 aplastic aplastic JJ cord-005453-4057qib7 806 15 anemia anemia NN cord-005453-4057qib7 806 16 : : : cord-005453-4057qib7 806 17 Single single JJ cord-005453-4057qib7 806 18 center center NN cord-005453-4057qib7 806 19 experience experience NN cord-005453-4057qib7 806 20 Zafer Zafer NNP cord-005453-4057qib7 806 21 Gulbas Gulbas NNP cord-005453-4057qib7 806 22 1 1 CD cord-005453-4057qib7 806 23 , , , cord-005453-4057qib7 806 24 Elif Elif NNP cord-005453-4057qib7 806 25 Birtas Birtas NNP cord-005453-4057qib7 806 26 Atesoglu Atesoglu NNP cord-005453-4057qib7 806 27 1 1 CD cord-005453-4057qib7 806 28 , , , cord-005453-4057qib7 806 29 Meral Meral NNP cord-005453-4057qib7 806 30 Sengezer Sengezer NNP cord-005453-4057qib7 806 31 1 1 CD cord-005453-4057qib7 806 32 , , , cord-005453-4057qib7 806 33 İmran İmran NNP cord-005453-4057qib7 806 34 Dora Dora NNP cord-005453-4057qib7 806 35 1 1 CD cord-005453-4057qib7 806 36 , , , cord-005453-4057qib7 806 37 Cigdem Cigdem NNP cord-005453-4057qib7 806 38 Eren Eren NNP cord-005453-4057qib7 806 39 1 1 CD cord-005453-4057qib7 806 40 , , , cord-005453-4057qib7 806 41 Suat Suat NNP cord-005453-4057qib7 806 42 Celik Celik NNP cord-005453-4057qib7 806 43 1 1 CD cord-005453-4057qib7 806 44 , , , cord-005453-4057qib7 806 45 Demet Demet NNP cord-005453-4057qib7 806 46 Cekdemir Cekdemir NNP cord-005453-4057qib7 806 47 1 1 CD cord-005453-4057qib7 806 48 Background Background NNP cord-005453-4057qib7 806 49 : : : cord-005453-4057qib7 807 1 Aplastic aplastic JJ cord-005453-4057qib7 807 2 anemia anemia NN cord-005453-4057qib7 807 3 is be VBZ cord-005453-4057qib7 807 4 a a DT cord-005453-4057qib7 807 5 syndrome syndrome NN cord-005453-4057qib7 807 6 of of IN cord-005453-4057qib7 807 7 bone bone NN cord-005453-4057qib7 807 8 marrow marrow NN cord-005453-4057qib7 807 9 failure failure NN cord-005453-4057qib7 807 10 characterized characterize VBN cord-005453-4057qib7 807 11 by by IN cord-005453-4057qib7 807 12 peripheral peripheral JJ cord-005453-4057qib7 807 13 pancytopenia pancytopenia NNS cord-005453-4057qib7 807 14 and and CC cord-005453-4057qib7 807 15 marrow marrow NN cord-005453-4057qib7 807 16 hypoplasia hypoplasia NN cord-005453-4057qib7 807 17 . . . cord-005453-4057qib7 808 1 Allogeneic allogeneic IN cord-005453-4057qib7 808 2 stem stem VBP cord-005453-4057qib7 808 3 cell cell NN cord-005453-4057qib7 808 4 transplantation transplantation NN cord-005453-4057qib7 808 5 from from IN cord-005453-4057qib7 808 6 HLAmatched hlamatched JJ cord-005453-4057qib7 808 7 sibling sibling NN cord-005453-4057qib7 808 8 is be VBZ cord-005453-4057qib7 808 9 performed perform VBN cord-005453-4057qib7 808 10 in in IN cord-005453-4057qib7 808 11 the the DT cord-005453-4057qib7 808 12 firstline firstline NN cord-005453-4057qib7 808 13 setting set VBG cord-005453-4057qib7 808 14 in in IN cord-005453-4057qib7 808 15 young young JJ cord-005453-4057qib7 808 16 aplastic aplastic JJ cord-005453-4057qib7 808 17 anemia anemia NN cord-005453-4057qib7 808 18 patients patient NNS cord-005453-4057qib7 808 19 and and CC cord-005453-4057qib7 808 20 in in IN cord-005453-4057qib7 808 21 elderly elderly JJ cord-005453-4057qib7 808 22 patients patient NNS cord-005453-4057qib7 808 23 who who WP cord-005453-4057qib7 808 24 are be VBP cord-005453-4057qib7 808 25 refractory refractory JJ cord-005453-4057qib7 808 26 to to IN cord-005453-4057qib7 808 27 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 808 28 treatment treatment NN cord-005453-4057qib7 808 29 . . . cord-005453-4057qib7 809 1 But but CC cord-005453-4057qib7 809 2 if if IN cord-005453-4057qib7 809 3 the the DT cord-005453-4057qib7 809 4 patient patient NN cord-005453-4057qib7 809 5 does do VBZ cord-005453-4057qib7 809 6 not not RB cord-005453-4057qib7 809 7 have have VB cord-005453-4057qib7 809 8 a a DT cord-005453-4057qib7 809 9 HLA HLA NNP cord-005453-4057qib7 809 10 - - HYPH cord-005453-4057qib7 809 11 matched match VBN cord-005453-4057qib7 809 12 sibling sibling NN cord-005453-4057qib7 809 13 , , , cord-005453-4057qib7 809 14 allogeneic allogeneic IN cord-005453-4057qib7 809 15 stem stem NN cord-005453-4057qib7 809 16 cell cell NN cord-005453-4057qib7 809 17 transplantation transplantation NN cord-005453-4057qib7 809 18 is be VBZ cord-005453-4057qib7 809 19 performed perform VBN cord-005453-4057qib7 809 20 from from IN cord-005453-4057qib7 809 21 unrelated unrelated JJ cord-005453-4057qib7 809 22 and and CC cord-005453-4057qib7 809 23 haploidentical haploidentical JJ cord-005453-4057qib7 809 24 donors donor NNS cord-005453-4057qib7 809 25 . . . cord-005453-4057qib7 810 1 In in IN cord-005453-4057qib7 810 2 this this DT cord-005453-4057qib7 810 3 study study NN cord-005453-4057qib7 810 4 , , , cord-005453-4057qib7 810 5 we -PRON- PRP cord-005453-4057qib7 810 6 analyzaed analyzaed VBP cord-005453-4057qib7 810 7 and and CC cord-005453-4057qib7 810 8 compared compare VBD cord-005453-4057qib7 810 9 the the DT cord-005453-4057qib7 810 10 results result NNS cord-005453-4057qib7 810 11 of of IN cord-005453-4057qib7 810 12 aplastic aplastic JJ cord-005453-4057qib7 810 13 anemia anemia NN cord-005453-4057qib7 810 14 patients patient NNS cord-005453-4057qib7 810 15 who who WP cord-005453-4057qib7 810 16 had have VBD cord-005453-4057qib7 810 17 undergone undergo VBN cord-005453-4057qib7 810 18 allogeneic allogeneic IN cord-005453-4057qib7 810 19 stem stem NN cord-005453-4057qib7 810 20 cell cell NN cord-005453-4057qib7 810 21 transplantation transplantation NN cord-005453-4057qib7 810 22 either either CC cord-005453-4057qib7 810 23 from from IN cord-005453-4057qib7 810 24 matched match VBN cord-005453-4057qib7 810 25 unrelated unrelated JJ cord-005453-4057qib7 810 26 or or CC cord-005453-4057qib7 810 27 haploidentical haploidentical JJ cord-005453-4057qib7 810 28 donors donor NNS cord-005453-4057qib7 810 29 . . . cord-005453-4057qib7 811 1 Methods method NNS cord-005453-4057qib7 811 2 : : : cord-005453-4057qib7 811 3 We -PRON- PRP cord-005453-4057qib7 811 4 collected collect VBD cord-005453-4057qib7 811 5 and and CC cord-005453-4057qib7 811 6 analyzed analyze VBD cord-005453-4057qib7 811 7 data datum NNS cord-005453-4057qib7 811 8 of of IN cord-005453-4057qib7 811 9 aplastic aplastic JJ cord-005453-4057qib7 811 10 anemia anemia NN cord-005453-4057qib7 811 11 patients patient NNS cord-005453-4057qib7 811 12 who who WP cord-005453-4057qib7 811 13 had have VBD cord-005453-4057qib7 811 14 undergone undergo VBN cord-005453-4057qib7 811 15 allogeneic allogeneic IN cord-005453-4057qib7 811 16 stem stem NN cord-005453-4057qib7 811 17 cell cell NN cord-005453-4057qib7 811 18 transplantation transplantation NN cord-005453-4057qib7 811 19 from from IN cord-005453-4057qib7 811 20 matched match VBN cord-005453-4057qib7 811 21 unrelated unrelated JJ cord-005453-4057qib7 811 22 or or CC cord-005453-4057qib7 811 23 haploidentical haploidentical JJ cord-005453-4057qib7 811 24 donor donor NN cord-005453-4057qib7 811 25 between between IN cord-005453-4057qib7 811 26 2011 2011 CD cord-005453-4057qib7 811 27 and and CC cord-005453-4057qib7 811 28 2018 2018 CD cord-005453-4057qib7 811 29 . . . cord-005453-4057qib7 812 1 Results result NNS cord-005453-4057qib7 812 2 : : : cord-005453-4057qib7 813 1 There there EX cord-005453-4057qib7 813 2 were be VBD cord-005453-4057qib7 813 3 10 10 CD cord-005453-4057qib7 813 4 patients patient NNS cord-005453-4057qib7 813 5 who who WP cord-005453-4057qib7 813 6 had have VBD cord-005453-4057qib7 813 7 received receive VBN cord-005453-4057qib7 813 8 allogeneic allogeneic JJ cord-005453-4057qib7 813 9 stem stem NN cord-005453-4057qib7 813 10 cell cell NN cord-005453-4057qib7 813 11 transplantation transplantation NN cord-005453-4057qib7 813 12 from from IN cord-005453-4057qib7 813 13 unrelated unrelated JJ cord-005453-4057qib7 813 14 donors donor NNS cord-005453-4057qib7 813 15 and and CC cord-005453-4057qib7 813 16 there there EX cord-005453-4057qib7 813 17 were be VBD cord-005453-4057qib7 813 18 10 10 CD cord-005453-4057qib7 813 19 patients patient NNS cord-005453-4057qib7 813 20 who who WP cord-005453-4057qib7 813 21 had have VBD cord-005453-4057qib7 813 22 undergone undergo VBN cord-005453-4057qib7 813 23 haploidentical haploidentical JJ cord-005453-4057qib7 813 24 transplantation transplantation NN cord-005453-4057qib7 813 25 . . . cord-005453-4057qib7 814 1 But but CC cord-005453-4057qib7 814 2 in in IN cord-005453-4057qib7 814 3 4 4 CD cord-005453-4057qib7 814 4 patients patient NNS cord-005453-4057qib7 814 5 who who WP cord-005453-4057qib7 814 6 had have VBD cord-005453-4057qib7 814 7 undergone undergo VBN cord-005453-4057qib7 814 8 haploidentical haploidentical JJ cord-005453-4057qib7 814 9 transplantation transplantation NN cord-005453-4057qib7 814 10 , , , cord-005453-4057qib7 814 11 engraftment engraftment NN cord-005453-4057qib7 814 12 failure failure NN cord-005453-4057qib7 814 13 had have VBD cord-005453-4057qib7 814 14 occurred occur VBN cord-005453-4057qib7 814 15 and and CC cord-005453-4057qib7 814 16 they -PRON- PRP cord-005453-4057qib7 814 17 were be VBD cord-005453-4057qib7 814 18 transplanted transplant VBN cord-005453-4057qib7 814 19 from from IN cord-005453-4057qib7 814 20 different different JJ cord-005453-4057qib7 814 21 haploidentical haploidentical JJ cord-005453-4057qib7 814 22 donors donor NNS cord-005453-4057qib7 814 23 fort fort NNP cord-005453-4057qib7 814 24 he -PRON- PRP cord-005453-4057qib7 814 25 second second JJ cord-005453-4057qib7 814 26 time time NN cord-005453-4057qib7 814 27 . . . cord-005453-4057qib7 815 1 So so RB cord-005453-4057qib7 815 2 a a DT cord-005453-4057qib7 815 3 total total NN cord-005453-4057qib7 815 4 of of IN cord-005453-4057qib7 815 5 10 10 CD cord-005453-4057qib7 815 6 unrelated unrelated JJ cord-005453-4057qib7 815 7 and and CC cord-005453-4057qib7 815 8 14 14 CD cord-005453-4057qib7 815 9 haploidentical haploidentical JJ cord-005453-4057qib7 815 10 transplants transplant NNS cord-005453-4057qib7 815 11 were be VBD cord-005453-4057qib7 815 12 performed perform VBN cord-005453-4057qib7 815 13 . . . cord-005453-4057qib7 816 1 The the DT cord-005453-4057qib7 816 2 median median JJ cord-005453-4057qib7 816 3 age age NN cord-005453-4057qib7 816 4 of of IN cord-005453-4057qib7 816 5 patients patient NNS cord-005453-4057qib7 816 6 who who WP cord-005453-4057qib7 816 7 had have VBD cord-005453-4057qib7 816 8 undergone undergo VBN cord-005453-4057qib7 816 9 unrelated unrelated JJ cord-005453-4057qib7 816 10 transplantation transplantation NN cord-005453-4057qib7 816 11 was be VBD cord-005453-4057qib7 816 12 29(16 29(16 CD cord-005453-4057qib7 816 13 - - SYM cord-005453-4057qib7 816 14 55 55 CD cord-005453-4057qib7 816 15 ) ) -RRB- cord-005453-4057qib7 816 16 and and CC cord-005453-4057qib7 816 17 the the DT cord-005453-4057qib7 816 18 median median JJ cord-005453-4057qib7 816 19 age age NN cord-005453-4057qib7 816 20 of of IN cord-005453-4057qib7 816 21 patients patient NNS cord-005453-4057qib7 816 22 who who WP cord-005453-4057qib7 816 23 had have VBD cord-005453-4057qib7 816 24 undergone undergo VBN cord-005453-4057qib7 816 25 unrelated unrelated JJ cord-005453-4057qib7 816 26 transplantation transplantation NN cord-005453-4057qib7 816 27 was be VBD cord-005453-4057qib7 816 28 22(19 22(19 CD cord-005453-4057qib7 816 29 - - SYM cord-005453-4057qib7 816 30 61 61 CD cord-005453-4057qib7 816 31 ) ) -RRB- cord-005453-4057qib7 816 32 . . . cord-005453-4057qib7 817 1 The the DT cord-005453-4057qib7 817 2 results result NNS cord-005453-4057qib7 817 3 of of IN cord-005453-4057qib7 817 4 the the DT cord-005453-4057qib7 817 5 haploidentical haploidentical JJ cord-005453-4057qib7 817 6 and and CC cord-005453-4057qib7 817 7 unrelated unrelated JJ cord-005453-4057qib7 817 8 transplantations transplantation NNS cord-005453-4057qib7 817 9 are be VBP cord-005453-4057qib7 817 10 shown show VBN cord-005453-4057qib7 817 11 in in IN cord-005453-4057qib7 817 12 Table Table NNP cord-005453-4057qib7 817 13 1 1 CD cord-005453-4057qib7 817 14 . . . cord-005453-4057qib7 818 1 The the DT cord-005453-4057qib7 818 2 neutrophil neutrophil NN cord-005453-4057qib7 818 3 and and CC cord-005453-4057qib7 818 4 platelet platelet NN cord-005453-4057qib7 818 5 engraftment engraftment NN cord-005453-4057qib7 818 6 times time NNS cord-005453-4057qib7 818 7 were be VBD cord-005453-4057qib7 818 8 significantly significantly RB cord-005453-4057qib7 818 9 longer long RBR cord-005453-4057qib7 818 10 in in IN cord-005453-4057qib7 818 11 haploidentical haploidentical JJ cord-005453-4057qib7 818 12 transplantations transplantation NNS cord-005453-4057qib7 818 13 ( ( -LRB- cord-005453-4057qib7 818 14 p=0,006 p=0,006 NNP cord-005453-4057qib7 818 15 and and CC cord-005453-4057qib7 818 16 p=0,005 p=0,005 NNP cord-005453-4057qib7 818 17 , , , cord-005453-4057qib7 818 18 respectively respectively RB cord-005453-4057qib7 818 19 ) ) -RRB- cord-005453-4057qib7 818 20 . . . cord-005453-4057qib7 819 1 However however RB cord-005453-4057qib7 819 2 , , , cord-005453-4057qib7 819 3 VOD VOD NNP cord-005453-4057qib7 819 4 , , , cord-005453-4057qib7 819 5 GVHD GVHD NNP cord-005453-4057qib7 819 6 and and CC cord-005453-4057qib7 819 7 100 100 CD cord-005453-4057qib7 819 8 day day NN cord-005453-4057qib7 819 9 mortality mortality NN cord-005453-4057qib7 819 10 rates rate NNS cord-005453-4057qib7 819 11 were be VBD cord-005453-4057qib7 819 12 not not RB cord-005453-4057qib7 819 13 different different JJ cord-005453-4057qib7 819 14 in in IN cord-005453-4057qib7 819 15 the the DT cord-005453-4057qib7 819 16 2 2 CD cord-005453-4057qib7 819 17 groups group NNS cord-005453-4057qib7 819 18 . . . cord-005453-4057qib7 820 1 Similarly similarly RB cord-005453-4057qib7 820 2 overall overall JJ cord-005453-4057qib7 820 3 survival survival NN cord-005453-4057qib7 820 4 ( ( -LRB- cord-005453-4057qib7 820 5 OS OS NNP cord-005453-4057qib7 820 6 ) ) -RRB- cord-005453-4057qib7 820 7 of of IN cord-005453-4057qib7 820 8 the the DT cord-005453-4057qib7 820 9 patients patient NNS cord-005453-4057qib7 820 10 who who WP cord-005453-4057qib7 820 11 had have VBD cord-005453-4057qib7 820 12 undergone undergo VBN cord-005453-4057qib7 820 13 haploidentical haploidentical JJ cord-005453-4057qib7 820 14 or or CC cord-005453-4057qib7 820 15 unrelated unrelated JJ cord-005453-4057qib7 820 16 transplantation transplantation NN cord-005453-4057qib7 820 17 were be VBD cord-005453-4057qib7 820 18 not not RB cord-005453-4057qib7 820 19 significantly significantly RB cord-005453-4057qib7 820 20 different different JJ cord-005453-4057qib7 820 21 ( ( -LRB- cord-005453-4057qib7 820 22 p=0,38 p=0,38 JJ cord-005453-4057qib7 820 23 ) ) -RRB- cord-005453-4057qib7 821 1 ( ( -LRB- cord-005453-4057qib7 821 2 Figure figure NN cord-005453-4057qib7 821 3 1 1 CD cord-005453-4057qib7 821 4 ) ) -RRB- cord-005453-4057qib7 821 5 . . . cord-005453-4057qib7 822 1 Conclusions conclusion NNS cord-005453-4057qib7 822 2 : : : cord-005453-4057qib7 823 1 Although although IN cord-005453-4057qib7 823 2 the the DT cord-005453-4057qib7 823 3 number number NN cord-005453-4057qib7 823 4 of of IN cord-005453-4057qib7 823 5 patients patient NNS cord-005453-4057qib7 823 6 are be VBP cord-005453-4057qib7 823 7 low low JJ cord-005453-4057qib7 823 8 in in IN cord-005453-4057qib7 823 9 this this DT cord-005453-4057qib7 823 10 study study NN cord-005453-4057qib7 823 11 , , , cord-005453-4057qib7 823 12 we -PRON- PRP cord-005453-4057qib7 823 13 can can MD cord-005453-4057qib7 823 14 conclude conclude VB cord-005453-4057qib7 823 15 that that IN cord-005453-4057qib7 823 16 urelated urelate VBN cord-005453-4057qib7 823 17 and and CC cord-005453-4057qib7 823 18 haploidentical haploidentical JJ cord-005453-4057qib7 823 19 transplantation transplantation NN cord-005453-4057qib7 823 20 in in IN cord-005453-4057qib7 823 21 aplastic aplastic JJ cord-005453-4057qib7 823 22 anemia anemia NN cord-005453-4057qib7 823 23 have have VBP cord-005453-4057qib7 823 24 comparable comparable JJ cord-005453-4057qib7 823 25 toxicity toxicity NN cord-005453-4057qib7 823 26 and and CC cord-005453-4057qib7 823 27 efficacy efficacy NN cord-005453-4057qib7 823 28 . . . cord-005453-4057qib7 824 1 Background background NN cord-005453-4057qib7 824 2 : : : cord-005453-4057qib7 825 1 Autologous autologous JJ cord-005453-4057qib7 825 2 stem stem NN cord-005453-4057qib7 825 3 cells cell NNS cord-005453-4057qib7 825 4 transplantation transplantation NN cord-005453-4057qib7 825 5 ( ( -LRB- cord-005453-4057qib7 825 6 aHSCT aHSCT NNP cord-005453-4057qib7 825 7 ) ) -RRB- cord-005453-4057qib7 825 8 is be VBZ cord-005453-4057qib7 825 9 an an DT cord-005453-4057qib7 825 10 effective effective JJ cord-005453-4057qib7 825 11 treatment treatment NN cord-005453-4057qib7 825 12 for for IN cord-005453-4057qib7 825 13 very very RB cord-005453-4057qib7 825 14 aggressive aggressive JJ cord-005453-4057qib7 825 15 autoimmune autoimmune JJ cord-005453-4057qib7 825 16 diseases disease NNS cord-005453-4057qib7 825 17 such such JJ cord-005453-4057qib7 825 18 as as IN cord-005453-4057qib7 825 19 multiple multiple JJ cord-005453-4057qib7 825 20 sclerosis sclerosis NN cord-005453-4057qib7 825 21 ( ( -LRB- cord-005453-4057qib7 825 22 MS MS NNP cord-005453-4057qib7 825 23 ) ) -RRB- cord-005453-4057qib7 825 24 . . . cord-005453-4057qib7 826 1 However however RB cord-005453-4057qib7 826 2 , , , cord-005453-4057qib7 826 3 toxicity toxicity NN cord-005453-4057qib7 826 4 remains remain VBZ cord-005453-4057qib7 826 5 the the DT cord-005453-4057qib7 826 6 major major JJ cord-005453-4057qib7 826 7 concern concern NN cord-005453-4057qib7 826 8 to to IN cord-005453-4057qib7 826 9 a a DT cord-005453-4057qib7 826 10 wide wide JJ cord-005453-4057qib7 826 11 application application NN cord-005453-4057qib7 826 12 of of IN cord-005453-4057qib7 826 13 this this DT cord-005453-4057qib7 826 14 approach approach NN cord-005453-4057qib7 826 15 . . . cord-005453-4057qib7 827 1 Post post JJ cord-005453-4057qib7 827 2 transplant transplant NN cord-005453-4057qib7 827 3 viral viral JJ cord-005453-4057qib7 827 4 reactivations reactivation NNS cord-005453-4057qib7 827 5 may may MD cord-005453-4057qib7 827 6 induce induce VB cord-005453-4057qib7 827 7 severe severe JJ cord-005453-4057qib7 827 8 complications complication NNS cord-005453-4057qib7 827 9 and and CC cord-005453-4057qib7 827 10 a a DT cord-005453-4057qib7 827 11 rigorous rigorous JJ cord-005453-4057qib7 827 12 monitoring monitoring NN cord-005453-4057qib7 827 13 of of IN cord-005453-4057qib7 827 14 peripheral peripheral JJ cord-005453-4057qib7 827 15 blood blood NN cord-005453-4057qib7 827 16 viral viral JJ cord-005453-4057qib7 827 17 load load NN cord-005453-4057qib7 827 18 for for IN cord-005453-4057qib7 827 19 a a DT cord-005453-4057qib7 827 20 prompt prompt JJ cord-005453-4057qib7 827 21 and and CC cord-005453-4057qib7 827 22 effective effective JJ cord-005453-4057qib7 827 23 therapy therapy NN cord-005453-4057qib7 827 24 is be VBZ cord-005453-4057qib7 827 25 required require VBN cord-005453-4057qib7 827 26 . . . cord-005453-4057qib7 828 1 A a DT cord-005453-4057qib7 828 2 higher high JJR cord-005453-4057qib7 828 3 rate rate NN cord-005453-4057qib7 828 4 of of IN cord-005453-4057qib7 828 5 EBV EBV NNP cord-005453-4057qib7 828 6 and and CC cord-005453-4057qib7 828 7 CMV CMV NNP cord-005453-4057qib7 828 8 reactivation reactivation NN cord-005453-4057qib7 828 9 has have VBZ cord-005453-4057qib7 828 10 been be VBN cord-005453-4057qib7 828 11 observed observe VBN cord-005453-4057qib7 828 12 in in IN cord-005453-4057qib7 828 13 patients patient NNS cord-005453-4057qib7 828 14 affected affect VBN cord-005453-4057qib7 828 15 by by IN cord-005453-4057qib7 828 16 MS MS NNP cord-005453-4057qib7 828 17 and and CC cord-005453-4057qib7 828 18 conditioned condition VBN cord-005453-4057qib7 828 19 with with IN cord-005453-4057qib7 828 20 BEAM BEAM NNP cord-005453-4057qib7 828 21 plus plus CC cord-005453-4057qib7 828 22 ATG ATG NNP cord-005453-4057qib7 828 23 compared compare VBN cord-005453-4057qib7 828 24 with with IN cord-005453-4057qib7 828 25 a a DT cord-005453-4057qib7 828 26 controlled control VBN cord-005453-4057qib7 828 27 group group NN cord-005453-4057qib7 828 28 of of IN cord-005453-4057qib7 828 29 lymphoma lymphoma NN cord-005453-4057qib7 828 30 patients patient NNS cord-005453-4057qib7 828 31 without without IN cord-005453-4057qib7 828 32 ATG ATG NNP cord-005453-4057qib7 828 33 in in IN cord-005453-4057qib7 828 34 the the DT cord-005453-4057qib7 828 35 conditioning conditioning NN cord-005453-4057qib7 828 36 regimen regimen NN cord-005453-4057qib7 828 37 [ [ -LRB- cord-005453-4057qib7 828 38 1 1 CD cord-005453-4057qib7 828 39 ] ] -RRB- cord-005453-4057qib7 828 40 . . . cord-005453-4057qib7 829 1 We -PRON- PRP cord-005453-4057qib7 829 2 report report VBP cord-005453-4057qib7 829 3 here here RB cord-005453-4057qib7 829 4 the the DT cord-005453-4057qib7 829 5 policy policy NN cord-005453-4057qib7 829 6 of of IN cord-005453-4057qib7 829 7 our -PRON- PRP$ cord-005453-4057qib7 829 8 Center Center NNP cord-005453-4057qib7 829 9 about about IN cord-005453-4057qib7 829 10 both both DT cord-005453-4057qib7 829 11 monitoring monitoring NN cord-005453-4057qib7 829 12 and and CC cord-005453-4057qib7 829 13 treatment treatment NN cord-005453-4057qib7 829 14 of of IN cord-005453-4057qib7 829 15 such such JJ cord-005453-4057qib7 829 16 side side NN cord-005453-4057qib7 829 17 effect effect NN cord-005453-4057qib7 829 18 . . . cord-005453-4057qib7 830 1 Methods method NNS cord-005453-4057qib7 830 2 : : : cord-005453-4057qib7 831 1 A a DT cord-005453-4057qib7 831 2 series series NN cord-005453-4057qib7 831 3 of of IN cord-005453-4057qib7 831 4 37 37 CD cord-005453-4057qib7 831 5 consecutive consecutive JJ cord-005453-4057qib7 831 6 patients patient NNS cord-005453-4057qib7 831 7 with with IN cord-005453-4057qib7 831 8 MS MS NNP cord-005453-4057qib7 831 9 , , , cord-005453-4057qib7 831 10 transplanted transplant VBN cord-005453-4057qib7 831 11 between between IN cord-005453-4057qib7 831 12 2014 2014 CD cord-005453-4057qib7 831 13 and and CC cord-005453-4057qib7 831 14 2018 2018 CD cord-005453-4057qib7 831 15 is be VBZ cord-005453-4057qib7 831 16 included include VBN cord-005453-4057qib7 831 17 in in IN cord-005453-4057qib7 831 18 this this DT cord-005453-4057qib7 831 19 analysis analysis NN cord-005453-4057qib7 831 20 . . . cord-005453-4057qib7 832 1 All all DT cord-005453-4057qib7 832 2 patients patient NNS cord-005453-4057qib7 832 3 were be VBD cord-005453-4057qib7 832 4 mobilized mobilize VBN cord-005453-4057qib7 832 5 with with IN cord-005453-4057qib7 832 6 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 832 7 4g 4g CD cord-005453-4057qib7 832 8 / / SYM cord-005453-4057qib7 832 9 sqm sqm NN cord-005453-4057qib7 832 10 + + CC cord-005453-4057qib7 832 11 G G NNP cord-005453-4057qib7 832 12 - - HYPH cord-005453-4057qib7 832 13 CSF CSF NNP cord-005453-4057qib7 832 14 and and CC cord-005453-4057qib7 832 15 conditioned condition VBN cord-005453-4057qib7 832 16 with with IN cord-005453-4057qib7 832 17 BEAM beam NN cord-005453-4057qib7 832 18 plus plus CC cord-005453-4057qib7 832 19 rabbit rabbit NN cord-005453-4057qib7 832 20 ATG ATG NNP cord-005453-4057qib7 832 21 ( ( -LRB- cord-005453-4057qib7 832 22 Thymoglobulin Thymoglobulin NNP cord-005453-4057qib7 832 23 © © NNP cord-005453-4057qib7 832 24 , , , cord-005453-4057qib7 832 25 7.5mg 7.5mg CD cord-005453-4057qib7 832 26 / / SYM cord-005453-4057qib7 832 27 Kg Kg NNP cord-005453-4057qib7 832 28 ) ) -RRB- cord-005453-4057qib7 832 29 . . . cord-005453-4057qib7 833 1 Monitoring monitoring NN cord-005453-4057qib7 833 2 of of IN cord-005453-4057qib7 833 3 CMV CMV NNP cord-005453-4057qib7 833 4 / / SYM cord-005453-4057qib7 833 5 EBV EBV NNP cord-005453-4057qib7 833 6 DNA DNA NNP cord-005453-4057qib7 833 7 on on IN cord-005453-4057qib7 833 8 whole whole JJ cord-005453-4057qib7 833 9 blood blood NN cord-005453-4057qib7 833 10 by by IN cord-005453-4057qib7 833 11 quantitative quantitative JJ cord-005453-4057qib7 833 12 PCR PCR NNP cord-005453-4057qib7 833 13 was be VBD cord-005453-4057qib7 833 14 performed perform VBN cord-005453-4057qib7 833 15 after after IN cord-005453-4057qib7 833 16 the the DT cord-005453-4057qib7 833 17 engraftment engraftment NN cord-005453-4057qib7 833 18 , , , cord-005453-4057qib7 833 19 weekly weekly RB cord-005453-4057qib7 833 20 for for IN cord-005453-4057qib7 833 21 at at RB cord-005453-4057qib7 833 22 least least RBS cord-005453-4057qib7 833 23 one one CD cord-005453-4057qib7 833 24 month month NN cord-005453-4057qib7 833 25 , , , cord-005453-4057qib7 833 26 then then RB cord-005453-4057qib7 833 27 at at IN cord-005453-4057qib7 833 28 longer long JJR cord-005453-4057qib7 833 29 intervals interval NNS cord-005453-4057qib7 833 30 . . . cord-005453-4057qib7 834 1 Pre pre JJ cord-005453-4057qib7 834 2 - - JJ cord-005453-4057qib7 834 3 emptive emptive JJ cord-005453-4057qib7 834 4 treatment treatment NN cord-005453-4057qib7 834 5 with with IN cord-005453-4057qib7 834 6 valgancyclovir valgancyclovir NNS cord-005453-4057qib7 834 7 was be VBD cord-005453-4057qib7 834 8 started start VBN cord-005453-4057qib7 834 9 in in IN cord-005453-4057qib7 834 10 case case NN cord-005453-4057qib7 834 11 of of IN cord-005453-4057qib7 834 12 CMV CMV NNP cord-005453-4057qib7 834 13 viral viral JJ cord-005453-4057qib7 834 14 load load NN cord-005453-4057qib7 834 15 ³1x10 ³1x10 CD cord-005453-4057qib7 834 16 ^ ^ SYM cord-005453-4057qib7 834 17 4 4 CD cord-005453-4057qib7 834 18 copies copy NNS cord-005453-4057qib7 834 19 / / SYM cord-005453-4057qib7 834 20 mL. mL. NNS cord-005453-4057qib7 834 21 In in IN cord-005453-4057qib7 834 22 case case NN cord-005453-4057qib7 834 23 of of IN cord-005453-4057qib7 834 24 EBV EBV NNP cord-005453-4057qib7 834 25 assay assay NN cord-005453-4057qib7 834 26 between between IN cord-005453-4057qib7 834 27 1x10 1x10 CD cord-005453-4057qib7 834 28 ^ ^ SYM cord-005453-4057qib7 834 29 4 4 CD cord-005453-4057qib7 834 30 and and CC cord-005453-4057qib7 835 1 1x10 1x10 CD cord-005453-4057qib7 835 2 ^ ^ SYM cord-005453-4057qib7 835 3 5 5 CD cord-005453-4057qib7 835 4 copies copy NNS cord-005453-4057qib7 835 5 / / SYM cord-005453-4057qib7 835 6 mL ml NN cord-005453-4057qib7 835 7 further further JJ cord-005453-4057qib7 835 8 determinations determination NNS cord-005453-4057qib7 835 9 were be VBD cord-005453-4057qib7 835 10 performed perform VBN cord-005453-4057qib7 835 11 and and CC cord-005453-4057qib7 835 12 Rituximab Rituximab NNP cord-005453-4057qib7 835 13 - - HYPH cord-005453-4057qib7 835 14 based base VBN cord-005453-4057qib7 835 15 treatment treatment NN cord-005453-4057qib7 835 16 was be VBD cord-005453-4057qib7 835 17 started start VBN cord-005453-4057qib7 835 18 if if IN cord-005453-4057qib7 835 19 the the DT cord-005453-4057qib7 835 20 viral viral JJ cord-005453-4057qib7 835 21 copies copy NNS cord-005453-4057qib7 835 22 exceeded exceed VBD cord-005453-4057qib7 835 23 1x10 1x10 CD cord-005453-4057qib7 835 24 5 5 CD cord-005453-4057qib7 835 25 copies copy NNS cord-005453-4057qib7 835 26 . . . cord-005453-4057qib7 836 1 Patients patient NNS cord-005453-4057qib7 836 2 received receive VBD cord-005453-4057qib7 836 3 treatment treatment NN cord-005453-4057qib7 836 4 in in IN cord-005453-4057qib7 836 5 case case NN cord-005453-4057qib7 836 6 of of IN cord-005453-4057qib7 836 7 symptomatic symptomatic JJ cord-005453-4057qib7 836 8 disease disease NN cord-005453-4057qib7 836 9 for for IN cord-005453-4057qib7 836 10 any any DT cord-005453-4057qib7 836 11 value value NN cord-005453-4057qib7 836 12 of of IN cord-005453-4057qib7 836 13 the the DT cord-005453-4057qib7 836 14 PCR PCR NNP cord-005453-4057qib7 836 15 of of IN cord-005453-4057qib7 836 16 both both DT cord-005453-4057qib7 836 17 viruses virus NNS cord-005453-4057qib7 836 18 or or CC cord-005453-4057qib7 836 19 EBV EBV NNP cord-005453-4057qib7 836 20 titer titer NN cord-005453-4057qib7 836 21 ³1x10 ³1x10 NNP cord-005453-4057qib7 836 22 ^ ^ SYM cord-005453-4057qib7 836 23 5 5 CD cord-005453-4057qib7 836 24 copies/ copies/ XX cord-005453-4057qib7 837 1 mL. mL. NNP cord-005453-4057qib7 837 2 Results result NNS cord-005453-4057qib7 837 3 : : : cord-005453-4057qib7 838 1 Detectable detectable JJ cord-005453-4057qib7 838 2 DNA DNA NNP cord-005453-4057qib7 838 3 for for IN cord-005453-4057qib7 838 4 CMV CMV NNP cord-005453-4057qib7 838 5 was be VBD cord-005453-4057qib7 838 6 observed observe VBN cord-005453-4057qib7 838 7 in in IN cord-005453-4057qib7 838 8 15/ 15/ CD cord-005453-4057qib7 838 9 37 37 CD cord-005453-4057qib7 838 10 ( ( -LRB- cord-005453-4057qib7 838 11 40,5 40,5 CD cord-005453-4057qib7 838 12 % % NN cord-005453-4057qib7 838 13 ) ) -RRB- cord-005453-4057qib7 838 14 patients patient NNS cord-005453-4057qib7 838 15 at at IN cord-005453-4057qib7 838 16 a a DT cord-005453-4057qib7 838 17 median median JJ cord-005453-4057qib7 838 18 time time NN cord-005453-4057qib7 838 19 from from IN cord-005453-4057qib7 838 20 transplant transplant NN cord-005453-4057qib7 838 21 of of IN cord-005453-4057qib7 838 22 23 23 CD cord-005453-4057qib7 838 23 days day NNS cord-005453-4057qib7 838 24 ( ( -LRB- cord-005453-4057qib7 838 25 range range VBP cord-005453-4057qib7 838 26 12 12 CD cord-005453-4057qib7 838 27 - - SYM cord-005453-4057qib7 838 28 36 36 CD cord-005453-4057qib7 838 29 ) ) -RRB- cord-005453-4057qib7 838 30 and and CC cord-005453-4057qib7 838 31 6/37 6/37 CD cord-005453-4057qib7 838 32 ( ( -LRB- cord-005453-4057qib7 838 33 16 16 CD cord-005453-4057qib7 838 34 % % NN cord-005453-4057qib7 838 35 ) ) -RRB- cord-005453-4057qib7 839 1 required require VBN cord-005453-4057qib7 839 2 pre pre JJ cord-005453-4057qib7 839 3 - - JJ cord-005453-4057qib7 839 4 emptive emptive JJ cord-005453-4057qib7 839 5 treatment treatment NN cord-005453-4057qib7 839 6 . . . cord-005453-4057qib7 840 1 All all DT cord-005453-4057qib7 840 2 patients patient NNS cord-005453-4057qib7 840 3 promptly promptly RB cord-005453-4057qib7 840 4 responded respond VBD cord-005453-4057qib7 840 5 to to IN cord-005453-4057qib7 840 6 treatment treatment NN cord-005453-4057qib7 840 7 within within IN cord-005453-4057qib7 840 8 2 2 CD cord-005453-4057qib7 840 9 weeks week NNS cord-005453-4057qib7 840 10 . . . cord-005453-4057qib7 841 1 EBV EBV NNP cord-005453-4057qib7 841 2 viral viral JJ cord-005453-4057qib7 841 3 load load NN cord-005453-4057qib7 841 4 was be VBD cord-005453-4057qib7 841 5 detectable detectable JJ cord-005453-4057qib7 841 6 in in IN cord-005453-4057qib7 841 7 19/37 19/37 CD cord-005453-4057qib7 841 8 patients patient NNS cord-005453-4057qib7 841 9 ( ( -LRB- cord-005453-4057qib7 841 10 51,3 51,3 CD cord-005453-4057qib7 841 11 % % NN cord-005453-4057qib7 841 12 ) ) -RRB- cord-005453-4057qib7 841 13 at at IN cord-005453-4057qib7 841 14 a a DT cord-005453-4057qib7 841 15 median median JJ cord-005453-4057qib7 841 16 time time NN cord-005453-4057qib7 841 17 of of IN cord-005453-4057qib7 841 18 22 22 CD cord-005453-4057qib7 841 19 days day NNS cord-005453-4057qib7 841 20 ( ( -LRB- cord-005453-4057qib7 841 21 range range VBP cord-005453-4057qib7 841 22 12 12 CD cord-005453-4057qib7 841 23 - - SYM cord-005453-4057qib7 841 24 52 52 CD cord-005453-4057qib7 841 25 ) ) -RRB- cord-005453-4057qib7 841 26 . . . cord-005453-4057qib7 842 1 One one CD cord-005453-4057qib7 842 2 patient patient NN cord-005453-4057qib7 842 3 out out IN cord-005453-4057qib7 842 4 of of IN cord-005453-4057qib7 842 5 19 19 CD cord-005453-4057qib7 842 6 started start VBD cord-005453-4057qib7 842 7 the the DT cord-005453-4057qib7 842 8 treatment treatment NN cord-005453-4057qib7 842 9 on on IN cord-005453-4057qib7 842 10 first first JJ cord-005453-4057qib7 842 11 determination determination NN cord-005453-4057qib7 842 12 for for IN cord-005453-4057qib7 842 13 high high JJ cord-005453-4057qib7 842 14 viral viral JJ cord-005453-4057qib7 842 15 load load NN cord-005453-4057qib7 842 16 ( ( -LRB- cord-005453-4057qib7 842 17 > > NN cord-005453-4057qib7 842 18 1x10 1x10 CD cord-005453-4057qib7 842 19 ^ ^ SYM cord-005453-4057qib7 842 20 6 6 CD cord-005453-4057qib7 842 21 / / SYM cord-005453-4057qib7 842 22 mL ml NN cord-005453-4057qib7 842 23 ) ) -RRB- cord-005453-4057qib7 842 24 ; ; : cord-005453-4057qib7 842 25 nine nine CD cord-005453-4057qib7 842 26 presented present VBD cord-005453-4057qib7 842 27 an an DT cord-005453-4057qib7 842 28 EBV EBV NNP cord-005453-4057qib7 842 29 viral viral JJ cord-005453-4057qib7 842 30 load load NN cord-005453-4057qib7 842 31 over over IN cord-005453-4057qib7 842 32 1x10 1x10 CD cord-005453-4057qib7 842 33 ^ ^ SYM cord-005453-4057qib7 842 34 4 4 CD cord-005453-4057qib7 842 35 copies copy NNS cord-005453-4057qib7 842 36 / / SYM cord-005453-4057qib7 842 37 ml ml NN cord-005453-4057qib7 842 38 , , , cord-005453-4057qib7 842 39 three three CD cord-005453-4057qib7 842 40 of of IN cord-005453-4057qib7 842 41 them -PRON- PRP cord-005453-4057qib7 842 42 were be VBD cord-005453-4057qib7 842 43 treated treat VBN cord-005453-4057qib7 842 44 thereafter thereafter RB cord-005453-4057qib7 842 45 for for IN cord-005453-4057qib7 842 46 the the DT cord-005453-4057qib7 842 47 persistent persistent JJ cord-005453-4057qib7 842 48 increase increase NN cord-005453-4057qib7 842 49 of of IN cord-005453-4057qib7 842 50 the the DT cord-005453-4057qib7 842 51 viral viral JJ cord-005453-4057qib7 842 52 load load NN cord-005453-4057qib7 842 53 ( ( -LRB- cord-005453-4057qib7 842 54 > > NFP cord-005453-4057qib7 842 55 10 10 CD cord-005453-4057qib7 842 56 5 5 CD cord-005453-4057qib7 842 57 /ml /ml . cord-005453-4057qib7 842 58 ) ) -RRB- cord-005453-4057qib7 842 59 . . . cord-005453-4057qib7 843 1 Six six CD cord-005453-4057qib7 843 2 patients patient NNS cord-005453-4057qib7 843 3 spontaneously spontaneously RB cord-005453-4057qib7 843 4 recovered recover VBD cord-005453-4057qib7 843 5 the the DT cord-005453-4057qib7 843 6 EBV EBV NNP cord-005453-4057qib7 843 7 reactivation reactivation NN cord-005453-4057qib7 843 8 . . . cord-005453-4057qib7 844 1 Previous previous JJ cord-005453-4057qib7 844 2 treatments treatment NNS cord-005453-4057qib7 844 3 were be VBD cord-005453-4057qib7 844 4 not not RB cord-005453-4057qib7 844 5 predictive predictive JJ cord-005453-4057qib7 844 6 of of IN cord-005453-4057qib7 844 7 any any DT cord-005453-4057qib7 844 8 higher high JJR cord-005453-4057qib7 844 9 risk risk NN cord-005453-4057qib7 844 10 of of IN cord-005453-4057qib7 844 11 viral viral JJ cord-005453-4057qib7 844 12 reactivation reactivation NN cord-005453-4057qib7 844 13 . . . cord-005453-4057qib7 845 1 No no DT cord-005453-4057qib7 845 2 impact impact NN cord-005453-4057qib7 845 3 on on IN cord-005453-4057qib7 845 4 engraftment engraftment NN cord-005453-4057qib7 845 5 related relate VBN cord-005453-4057qib7 845 6 to to IN cord-005453-4057qib7 845 7 the the DT cord-005453-4057qib7 845 8 reactivation reactivation NN cord-005453-4057qib7 845 9 was be VBD cord-005453-4057qib7 845 10 observed observe VBN cord-005453-4057qib7 845 11 . . . cord-005453-4057qib7 846 1 Conclusions conclusion NNS cord-005453-4057qib7 846 2 : : : cord-005453-4057qib7 847 1 This this DT cord-005453-4057qib7 847 2 policy policy NN cord-005453-4057qib7 847 3 shows show VBZ cord-005453-4057qib7 847 4 that that IN cord-005453-4057qib7 847 5 , , , cord-005453-4057qib7 847 6 despite despite IN cord-005453-4057qib7 847 7 a a DT cord-005453-4057qib7 847 8 high high JJ cord-005453-4057qib7 847 9 rate rate NN cord-005453-4057qib7 847 10 of of IN cord-005453-4057qib7 847 11 CMV CMV NNP cord-005453-4057qib7 847 12 and and CC cord-005453-4057qib7 847 13 EBV EBV NNP cord-005453-4057qib7 847 14 reactivation reactivation NN cord-005453-4057qib7 847 15 , , , cord-005453-4057qib7 847 16 no no DT cord-005453-4057qib7 847 17 grade grade NN cord-005453-4057qib7 847 18 III III NNP cord-005453-4057qib7 847 19 - - HYPH cord-005453-4057qib7 847 20 IV IV NNP cord-005453-4057qib7 847 21 adverse adverse JJ cord-005453-4057qib7 847 22 events event NNS cord-005453-4057qib7 847 23 were be VBD cord-005453-4057qib7 847 24 observed observe VBN cord-005453-4057qib7 847 25 , , , cord-005453-4057qib7 847 26 suggesting suggest VBG cord-005453-4057qib7 847 27 the the DT cord-005453-4057qib7 847 28 key key JJ cord-005453-4057qib7 847 29 role role NN cord-005453-4057qib7 847 30 of of IN cord-005453-4057qib7 847 31 viral viral JJ cord-005453-4057qib7 847 32 monitoring monitoring NN cord-005453-4057qib7 847 33 in in IN cord-005453-4057qib7 847 34 these these DT cord-005453-4057qib7 847 35 patients patient NNS cord-005453-4057qib7 847 36 and and CC cord-005453-4057qib7 847 37 the the DT cord-005453-4057qib7 847 38 efficacy efficacy NN cord-005453-4057qib7 847 39 of of IN cord-005453-4057qib7 847 40 the the DT cord-005453-4057qib7 847 41 preemptive preemptive JJ cord-005453-4057qib7 847 42 treatment treatment NN cord-005453-4057qib7 847 43 . . . cord-005453-4057qib7 848 1 EBV EBV NNP cord-005453-4057qib7 848 2 reactivation reactivation NN cord-005453-4057qib7 848 3 at at IN cord-005453-4057qib7 848 4 low low JJ cord-005453-4057qib7 848 5 titers titer NNS cord-005453-4057qib7 848 6 should should MD cord-005453-4057qib7 848 7 be be VB cord-005453-4057qib7 848 8 monitored monitor VBN cord-005453-4057qib7 848 9 to to TO cord-005453-4057qib7 848 10 identify identify VB cord-005453-4057qib7 848 11 those those DT cord-005453-4057qib7 848 12 cases case NNS cord-005453-4057qib7 848 13 that that WDT cord-005453-4057qib7 848 14 could could MD cord-005453-4057qib7 848 15 achieve achieve VB cord-005453-4057qib7 848 16 a a DT cord-005453-4057qib7 848 17 spontaneous spontaneous JJ cord-005453-4057qib7 848 18 resolution resolution NN cord-005453-4057qib7 848 19 and and CC cord-005453-4057qib7 848 20 avoid avoid VB cord-005453-4057qib7 848 21 the the DT cord-005453-4057qib7 848 22 induction induction NN cord-005453-4057qib7 848 23 of of IN cord-005453-4057qib7 848 24 further further JJ cord-005453-4057qib7 848 25 immunosuppression immunosuppression NN cord-005453-4057qib7 848 26 by by IN cord-005453-4057qib7 848 27 Rituximab Rituximab NNP cord-005453-4057qib7 848 28 . . . cord-005453-4057qib7 849 1 These these DT cord-005453-4057qib7 849 2 data datum NNS cord-005453-4057qib7 849 3 confirm confirm VBP cord-005453-4057qib7 849 4 that that IN cord-005453-4057qib7 849 5 patients patient NNS cord-005453-4057qib7 849 6 diagnosed diagnose VBN cord-005453-4057qib7 849 7 with with IN cord-005453-4057qib7 849 8 AD ad NN cord-005453-4057qib7 849 9 undergoing undergo VBG cord-005453-4057qib7 849 10 autologous autologous JJ cord-005453-4057qib7 849 11 HSCT HSCT NNP cord-005453-4057qib7 849 12 need need VBP cord-005453-4057qib7 849 13 a a DT cord-005453-4057qib7 849 14 more more RBR cord-005453-4057qib7 849 15 intense intense JJ cord-005453-4057qib7 849 16 pattern pattern NN cord-005453-4057qib7 849 17 of of IN cord-005453-4057qib7 849 18 care care NN cord-005453-4057qib7 849 19 than than IN cord-005453-4057qib7 849 20 hematological hematological JJ cord-005453-4057qib7 849 21 patients patient NNS cord-005453-4057qib7 849 22 . . . cord-005453-4057qib7 850 1 Background background NN cord-005453-4057qib7 850 2 : : : cord-005453-4057qib7 851 1 Autoimmune autoimmune JJ cord-005453-4057qib7 851 2 diseases disease NNS cord-005453-4057qib7 851 3 are be VBP cord-005453-4057qib7 851 4 chronic chronic JJ cord-005453-4057qib7 851 5 serious serious JJ cord-005453-4057qib7 851 6 conditions condition NNS cord-005453-4057qib7 851 7 that that WDT cord-005453-4057qib7 851 8 are be VBP cord-005453-4057qib7 851 9 often often RB cord-005453-4057qib7 851 10 refractory refractory JJ cord-005453-4057qib7 851 11 to to IN cord-005453-4057qib7 851 12 standard standard JJ cord-005453-4057qib7 851 13 therapies therapy NNS cord-005453-4057qib7 851 14 . . . cord-005453-4057qib7 852 1 Since since IN cord-005453-4057qib7 852 2 1996 1996 CD cord-005453-4057qib7 852 3 , , , cord-005453-4057qib7 852 4 autologous autologous JJ cord-005453-4057qib7 852 5 haematopoietic haematopoietic JJ cord-005453-4057qib7 852 6 stem stem NN cord-005453-4057qib7 852 7 cell cell NN cord-005453-4057qib7 852 8 transplantation transplantation NN cord-005453-4057qib7 852 9 ( ( -LRB- cord-005453-4057qib7 852 10 HSCT HSCT NNP cord-005453-4057qib7 852 11 ) ) -RRB- cord-005453-4057qib7 852 12 has have VBZ cord-005453-4057qib7 852 13 been be VBN cord-005453-4057qib7 852 14 a a DT cord-005453-4057qib7 852 15 very very RB cord-005453-4057qib7 852 16 promising promising JJ cord-005453-4057qib7 852 17 alternative alternative NN cord-005453-4057qib7 852 18 that that WDT cord-005453-4057qib7 852 19 has have VBZ cord-005453-4057qib7 852 20 shown show VBN cord-005453-4057qib7 852 21 satisfactory satisfactory JJ cord-005453-4057qib7 852 22 long long JJ cord-005453-4057qib7 852 23 - - HYPH cord-005453-4057qib7 852 24 term term NN cord-005453-4057qib7 852 25 results result NNS cord-005453-4057qib7 852 26 . . . cord-005453-4057qib7 853 1 The the DT cord-005453-4057qib7 853 2 aim aim NN cord-005453-4057qib7 853 3 of of IN cord-005453-4057qib7 853 4 this this DT cord-005453-4057qib7 853 5 study study NN cord-005453-4057qib7 853 6 is be VBZ cord-005453-4057qib7 853 7 to to TO cord-005453-4057qib7 853 8 evaluate evaluate VB cord-005453-4057qib7 853 9 immune immune JJ cord-005453-4057qib7 853 10 reconstitution reconstitution NN cord-005453-4057qib7 853 11 and and CC cord-005453-4057qib7 853 12 mortality mortality NN cord-005453-4057qib7 853 13 following follow VBG cord-005453-4057qib7 853 14 HSCT HSCT NNP cord-005453-4057qib7 853 15 in in IN cord-005453-4057qib7 853 16 patients patient NNS cord-005453-4057qib7 853 17 with with IN cord-005453-4057qib7 853 18 autoimmune autoimmune JJ cord-005453-4057qib7 853 19 disease disease NN cord-005453-4057qib7 853 20 . . . cord-005453-4057qib7 854 1 Methods method NNS cord-005453-4057qib7 854 2 : : : cord-005453-4057qib7 854 3 A a DT cord-005453-4057qib7 854 4 retrospective retrospective JJ cord-005453-4057qib7 854 5 study study NN cord-005453-4057qib7 854 6 was be VBD cord-005453-4057qib7 854 7 conducted conduct VBN cord-005453-4057qib7 854 8 on on IN cord-005453-4057qib7 854 9 patients patient NNS cord-005453-4057qib7 854 10 with with IN cord-005453-4057qib7 854 11 diagnosis diagnosis NN cord-005453-4057qib7 854 12 of of IN cord-005453-4057qib7 854 13 autoimmune autoimmune JJ cord-005453-4057qib7 854 14 diseases disease NNS cord-005453-4057qib7 854 15 that that WDT cord-005453-4057qib7 854 16 underwent undergo VBD cord-005453-4057qib7 854 17 autologous autologous JJ cord-005453-4057qib7 854 18 HSCT HSCT NNP cord-005453-4057qib7 854 19 between between IN cord-005453-4057qib7 854 20 July July NNP cord-005453-4057qib7 854 21 2012 2012 CD cord-005453-4057qib7 854 22 and and CC cord-005453-4057qib7 854 23 January January NNP cord-005453-4057qib7 854 24 2018 2018 CD cord-005453-4057qib7 854 25 at at IN cord-005453-4057qib7 854 26 a a DT cord-005453-4057qib7 854 27 tertiary tertiary JJ cord-005453-4057qib7 854 28 referral referral JJ cord-005453-4057qib7 854 29 center center NN cord-005453-4057qib7 854 30 in in IN cord-005453-4057qib7 854 31 Colombia Colombia NNP cord-005453-4057qib7 854 32 , , , cord-005453-4057qib7 854 33 South South NNP cord-005453-4057qib7 854 34 America America NNP cord-005453-4057qib7 854 35 . . . cord-005453-4057qib7 855 1 Descriptive descriptive JJ cord-005453-4057qib7 855 2 statistics statistic NNS cord-005453-4057qib7 855 3 were be VBD cord-005453-4057qib7 855 4 used use VBN cord-005453-4057qib7 855 5 to to TO cord-005453-4057qib7 855 6 analyze analyze VB cord-005453-4057qib7 855 7 patient patient NN cord-005453-4057qib7 855 8 's 's POS cord-005453-4057qib7 855 9 demographic demographic JJ cord-005453-4057qib7 855 10 and and CC cord-005453-4057qib7 855 11 clinic clinic NN cord-005453-4057qib7 855 12 characteristics characteristic NNS cord-005453-4057qib7 855 13 . . . cord-005453-4057qib7 856 1 Results result NNS cord-005453-4057qib7 856 2 : : : cord-005453-4057qib7 857 1 Seven seven CD cord-005453-4057qib7 857 2 patients patient NNS cord-005453-4057qib7 857 3 were be VBD cord-005453-4057qib7 857 4 included include VBN cord-005453-4057qib7 857 5 , , , cord-005453-4057qib7 857 6 with with IN cord-005453-4057qib7 857 7 a a DT cord-005453-4057qib7 857 8 mean mean JJ cord-005453-4057qib7 857 9 age age NN cord-005453-4057qib7 857 10 of of IN cord-005453-4057qib7 857 11 37 37 CD cord-005453-4057qib7 857 12 years year NNS cord-005453-4057qib7 857 13 ( ( -LRB- cord-005453-4057qib7 857 14 range range VBP cord-005453-4057qib7 857 15 26 26 CD cord-005453-4057qib7 857 16 - - SYM cord-005453-4057qib7 857 17 57 57 CD cord-005453-4057qib7 857 18 ) ) -RRB- cord-005453-4057qib7 857 19 . . . cord-005453-4057qib7 858 1 Five five CD cord-005453-4057qib7 858 2 patients patient NNS cord-005453-4057qib7 858 3 were be VBD cord-005453-4057qib7 858 4 female female JJ cord-005453-4057qib7 858 5 ( ( -LRB- cord-005453-4057qib7 858 6 71 71 CD cord-005453-4057qib7 858 7 % % NN cord-005453-4057qib7 858 8 ) ) -RRB- cord-005453-4057qib7 858 9 . . . cord-005453-4057qib7 859 1 The the DT cord-005453-4057qib7 859 2 indications indication NNS cord-005453-4057qib7 859 3 for for IN cord-005453-4057qib7 859 4 HSCT HSCT NNP cord-005453-4057qib7 859 5 were be VBD cord-005453-4057qib7 859 6 systemic systemic JJ cord-005453-4057qib7 859 7 sclerosis sclerosis NN cord-005453-4057qib7 859 8 ( ( -LRB- cord-005453-4057qib7 859 9 n=3 n=3 NN cord-005453-4057qib7 859 10 ) ) -RRB- cord-005453-4057qib7 859 11 , , , cord-005453-4057qib7 859 12 multiple multiple JJ cord-005453-4057qib7 859 13 sclerosis sclerosis NN cord-005453-4057qib7 859 14 ( ( -LRB- cord-005453-4057qib7 859 15 n=2 n=2 NNP cord-005453-4057qib7 859 16 ) ) -RRB- cord-005453-4057qib7 859 17 , , , cord-005453-4057qib7 859 18 and and CC cord-005453-4057qib7 859 19 myasthenia myasthenia NN cord-005453-4057qib7 859 20 gravis gravis NN cord-005453-4057qib7 859 21 ( ( -LRB- cord-005453-4057qib7 859 22 n=2 n=2 NNS cord-005453-4057qib7 859 23 ) ) -RRB- cord-005453-4057qib7 859 24 . . . cord-005453-4057qib7 860 1 The the DT cord-005453-4057qib7 860 2 conditioning conditioning NN cord-005453-4057qib7 860 3 regimen regimen NN cord-005453-4057qib7 860 4 administered administer VBN cord-005453-4057qib7 860 5 in in IN cord-005453-4057qib7 860 6 patients patient NNS cord-005453-4057qib7 860 7 with with IN cord-005453-4057qib7 860 8 systemic systemic JJ cord-005453-4057qib7 860 9 sclerosis sclerosis NN cord-005453-4057qib7 860 10 was be VBD cord-005453-4057qib7 860 11 cyclophosphamide cyclophosphamide JJ cord-005453-4057qib7 860 12 + + CC cord-005453-4057qib7 861 1 human human JJ cord-005453-4057qib7 861 2 anti anti NNP cord-005453-4057qib7 861 3 - - JJ cord-005453-4057qib7 861 4 T t JJ cord-005453-4057qib7 861 5 lymphocyte lymphocyte NN cord-005453-4057qib7 861 6 immunoglobulin immunoglobulin NN cord-005453-4057qib7 861 7 , , , cord-005453-4057qib7 861 8 BEAM BEAM NNP cord-005453-4057qib7 861 9 ( ( -LRB- cord-005453-4057qib7 861 10 Carmustine Carmustine NNP cord-005453-4057qib7 861 11 , , , cord-005453-4057qib7 861 12 Etoposide Etoposide NNP cord-005453-4057qib7 861 13 , , , cord-005453-4057qib7 861 14 Cytarabine Cytarabine NNP cord-005453-4057qib7 861 15 ( ( -LRB- cord-005453-4057qib7 861 16 Ara Ara NNP cord-005453-4057qib7 861 17 - - HYPH cord-005453-4057qib7 861 18 C C NNP cord-005453-4057qib7 861 19 ) ) -RRB- cord-005453-4057qib7 861 20 , , , cord-005453-4057qib7 861 21 and and CC cord-005453-4057qib7 861 22 Melphalan Melphalan NNP cord-005453-4057qib7 861 23 ) ) -RRB- cord-005453-4057qib7 861 24 + + CC cord-005453-4057qib7 861 25 Human human JJ cord-005453-4057qib7 861 26 anti anti JJ cord-005453-4057qib7 861 27 - - JJ cord-005453-4057qib7 861 28 T t JJ cord-005453-4057qib7 861 29 lymphocyte lymphocyte NN cord-005453-4057qib7 861 30 immunoglobulin immunoglobulin NN cord-005453-4057qib7 861 31 in in IN cord-005453-4057qib7 861 32 patients patient NNS cord-005453-4057qib7 861 33 with with IN cord-005453-4057qib7 861 34 multiple multiple JJ cord-005453-4057qib7 861 35 sclerosis sclerosis NN cord-005453-4057qib7 861 36 , , , cord-005453-4057qib7 861 37 and and CC cord-005453-4057qib7 861 38 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 861 39 + + CC cord-005453-4057qib7 861 40 Human human JJ cord-005453-4057qib7 861 41 anti anti JJ cord-005453-4057qib7 861 42 - - JJ cord-005453-4057qib7 861 43 T t JJ cord-005453-4057qib7 861 44 lymphocyte lymphocyte NN cord-005453-4057qib7 861 45 immunoglobulin immunoglobulin NN cord-005453-4057qib7 861 46 in in IN cord-005453-4057qib7 861 47 myasthenia myasthenia NN cord-005453-4057qib7 861 48 gravis gravis NN cord-005453-4057qib7 861 49 . . . cord-005453-4057qib7 862 1 Median median JJ cord-005453-4057qib7 862 2 time time NN cord-005453-4057qib7 862 3 to to IN cord-005453-4057qib7 862 4 myeloid myeloid NN cord-005453-4057qib7 862 5 engraftment engraftment NN cord-005453-4057qib7 862 6 ( ( -LRB- cord-005453-4057qib7 862 7 neutrophils>0.5×109 neutrophils>0.5×109 NNP cord-005453-4057qib7 862 8 / / SYM cord-005453-4057qib7 862 9 L L NNP cord-005453-4057qib7 862 10 ) ) -RRB- cord-005453-4057qib7 862 11 was be VBD cord-005453-4057qib7 862 12 12 12 CD cord-005453-4057qib7 862 13 days day NNS cord-005453-4057qib7 862 14 post post NN cord-005453-4057qib7 862 15 - - NN cord-005453-4057qib7 862 16 transplantation transplantation NN cord-005453-4057qib7 862 17 , , , cord-005453-4057qib7 862 18 and and CC cord-005453-4057qib7 862 19 platelet platelet NN cord-005453-4057qib7 862 20 engraftment engraftment NN cord-005453-4057qib7 862 21 , , , cord-005453-4057qib7 862 22 defined define VBN cord-005453-4057qib7 862 23 as as IN cord-005453-4057qib7 862 24 > > XX cord-005453-4057qib7 862 25 20,000 20,000 CD cord-005453-4057qib7 862 26 platelets platelet NNS cord-005453-4057qib7 862 27 / / SYM cord-005453-4057qib7 862 28 mm mm NNP cord-005453-4057qib7 862 29 3 3 CD cord-005453-4057qib7 862 30 untransfused untransfuse VBD cord-005453-4057qib7 862 31 , , , cord-005453-4057qib7 862 32 was be VBD cord-005453-4057qib7 862 33 11 11 CD cord-005453-4057qib7 862 34 days day NNS cord-005453-4057qib7 862 35 post post NN cord-005453-4057qib7 862 36 - - JJ cord-005453-4057qib7 862 37 HSCT HSCT NNP cord-005453-4057qib7 862 38 . . . cord-005453-4057qib7 863 1 Median median JJ cord-005453-4057qib7 863 2 time time NN cord-005453-4057qib7 863 3 of of IN cord-005453-4057qib7 863 4 hospitalization hospitalization NN cord-005453-4057qib7 863 5 was be VBD cord-005453-4057qib7 863 6 21 21 CD cord-005453-4057qib7 863 7 days day NNS cord-005453-4057qib7 864 1 ( ( -LRB- cord-005453-4057qib7 864 2 range range NNP cord-005453-4057qib7 864 3 11 11 CD cord-005453-4057qib7 864 4 - - SYM cord-005453-4057qib7 864 5 66 66 CD cord-005453-4057qib7 864 6 ) ) -RRB- cord-005453-4057qib7 864 7 ; ; : cord-005453-4057qib7 864 8 longer long RBR cord-005453-4057qib7 864 9 in in IN cord-005453-4057qib7 864 10 - - HYPH cord-005453-4057qib7 864 11 patient patient NN cord-005453-4057qib7 864 12 management management NN cord-005453-4057qib7 864 13 was be VBD cord-005453-4057qib7 864 14 due due JJ cord-005453-4057qib7 864 15 to to IN cord-005453-4057qib7 864 16 infectious infectious JJ cord-005453-4057qib7 864 17 complications complication NNS cord-005453-4057qib7 864 18 . . . cord-005453-4057qib7 865 1 Infectious infectious JJ cord-005453-4057qib7 865 2 complications complication NNS cord-005453-4057qib7 865 3 included include VBD cord-005453-4057qib7 865 4 bacteremia bacteremia NN cord-005453-4057qib7 865 5 caused cause VBN cord-005453-4057qib7 865 6 by by IN cord-005453-4057qib7 865 7 E. E. NNP cord-005453-4057qib7 865 8 Coli Coli NNP cord-005453-4057qib7 865 9 and and CC cord-005453-4057qib7 865 10 pneumocystis pneumocystis NN cord-005453-4057qib7 865 11 pneumonia pneumonia NN cord-005453-4057qib7 865 12 that that WDT cord-005453-4057qib7 865 13 resulted result VBD cord-005453-4057qib7 865 14 in in IN cord-005453-4057qib7 865 15 septic septic JJ cord-005453-4057qib7 865 16 shock shock NN cord-005453-4057qib7 865 17 and and CC cord-005453-4057qib7 865 18 acute acute JJ cord-005453-4057qib7 865 19 respiratory respiratory JJ cord-005453-4057qib7 865 20 failure failure NN cord-005453-4057qib7 865 21 , , , cord-005453-4057qib7 865 22 respectively respectively RB cord-005453-4057qib7 865 23 . . . cord-005453-4057qib7 866 1 Evaluating evaluate VBG cord-005453-4057qib7 866 2 T t NN cord-005453-4057qib7 866 3 - - HYPH cord-005453-4057qib7 866 4 cell cell NN cord-005453-4057qib7 866 5 immune immune JJ cord-005453-4057qib7 866 6 reconstitution reconstitution NN cord-005453-4057qib7 866 7 , , , cord-005453-4057qib7 866 8 none none NN cord-005453-4057qib7 866 9 of of IN cord-005453-4057qib7 866 10 the the DT cord-005453-4057qib7 866 11 patients patient NNS cord-005453-4057qib7 866 12 had have VBD cord-005453-4057qib7 866 13 reached reach VBN cord-005453-4057qib7 866 14 normal normal JJ cord-005453-4057qib7 866 15 CD4 CD4 NNP cord-005453-4057qib7 866 16 + + CC cord-005453-4057qib7 866 17 cell cell NN cord-005453-4057qib7 866 18 value value NN cord-005453-4057qib7 866 19 after after IN cord-005453-4057qib7 866 20 one one CD cord-005453-4057qib7 866 21 year year NN cord-005453-4057qib7 866 22 of of IN cord-005453-4057qib7 866 23 HSCT HSCT NNP cord-005453-4057qib7 866 24 follow follow NN cord-005453-4057qib7 866 25 - - HYPH cord-005453-4057qib7 866 26 up up NN cord-005453-4057qib7 866 27 . . . cord-005453-4057qib7 867 1 Four four CD cord-005453-4057qib7 867 2 patients patient NNS cord-005453-4057qib7 867 3 ( ( -LRB- cord-005453-4057qib7 867 4 57.1 57.1 CD cord-005453-4057qib7 867 5 % % NN cord-005453-4057qib7 867 6 ) ) -RRB- cord-005453-4057qib7 867 7 reached reach VBD cord-005453-4057qib7 867 8 normal normal JJ cord-005453-4057qib7 867 9 CD8 CD8 NNS cord-005453-4057qib7 867 10 + + CC cord-005453-4057qib7 867 11 cells cell NNS cord-005453-4057qib7 867 12 value value NN cord-005453-4057qib7 867 13 at at IN cord-005453-4057qib7 867 14 3 3 CD cord-005453-4057qib7 867 15 months month NNS cord-005453-4057qib7 867 16 post post JJ cord-005453-4057qib7 867 17 - - JJ cord-005453-4057qib7 867 18 HSCT HSCT NNP cord-005453-4057qib7 867 19 . . . cord-005453-4057qib7 868 1 Regarding regard VBG cord-005453-4057qib7 868 2 Bcell Bcell NNP cord-005453-4057qib7 868 3 immune immune JJ cord-005453-4057qib7 868 4 reconstitution reconstitution NN cord-005453-4057qib7 868 5 , , , cord-005453-4057qib7 868 6 85.7 85.7 CD cord-005453-4057qib7 868 7 % % NN cord-005453-4057qib7 868 8 of of IN cord-005453-4057qib7 868 9 the the DT cord-005453-4057qib7 868 10 patients patient NNS cord-005453-4057qib7 868 11 ( ( -LRB- cord-005453-4057qib7 868 12 6/7 6/7 CD cord-005453-4057qib7 868 13 ) ) -RRB- cord-005453-4057qib7 868 14 had have VBD cord-005453-4057qib7 868 15 reached reach VBN cord-005453-4057qib7 868 16 both both DT cord-005453-4057qib7 868 17 IgG IgG NNP cord-005453-4057qib7 868 18 and and CC cord-005453-4057qib7 868 19 IgA IgA NNP cord-005453-4057qib7 868 20 normal normal JJ cord-005453-4057qib7 868 21 levels level NNS cord-005453-4057qib7 868 22 at at IN cord-005453-4057qib7 868 23 one one CD cord-005453-4057qib7 868 24 - - HYPH cord-005453-4057qib7 868 25 month month NN cord-005453-4057qib7 868 26 post post NN cord-005453-4057qib7 868 27 - - JJ cord-005453-4057qib7 868 28 HSCT HSCT NNP cord-005453-4057qib7 868 29 , , , cord-005453-4057qib7 868 30 and and CC cord-005453-4057qib7 868 31 four four CD cord-005453-4057qib7 868 32 patients patient NNS cord-005453-4057qib7 868 33 ( ( -LRB- cord-005453-4057qib7 868 34 57.1 57.1 CD cord-005453-4057qib7 868 35 % % NN cord-005453-4057qib7 868 36 ) ) -RRB- cord-005453-4057qib7 868 37 had have VBD cord-005453-4057qib7 868 38 achieved achieve VBN cord-005453-4057qib7 868 39 normal normal JJ cord-005453-4057qib7 868 40 IgM igm NN cord-005453-4057qib7 868 41 Background Background NNP cord-005453-4057qib7 868 42 : : : cord-005453-4057qib7 868 43 Multiple Multiple NNP cord-005453-4057qib7 868 44 sclerosis(MS sclerosis(MS NNPS cord-005453-4057qib7 868 45 ) ) -RRB- cord-005453-4057qib7 868 46 is be VBZ cord-005453-4057qib7 868 47 an an DT cord-005453-4057qib7 868 48 inflammatory inflammatory JJ cord-005453-4057qib7 868 49 disease disease NN cord-005453-4057qib7 868 50 caused cause VBN cord-005453-4057qib7 868 51 by by IN cord-005453-4057qib7 868 52 autoimmune autoimmune JJ cord-005453-4057qib7 868 53 reactivity reactivity NN cord-005453-4057qib7 868 54 of of IN cord-005453-4057qib7 868 55 T T NNP cord-005453-4057qib7 868 56 cells cell NNS cord-005453-4057qib7 868 57 against against IN cord-005453-4057qib7 868 58 myelin myelin NN cord-005453-4057qib7 868 59 . . . cord-005453-4057qib7 869 1 There there EX cord-005453-4057qib7 869 2 is be VBZ cord-005453-4057qib7 869 3 accumulating accumulate VBG cord-005453-4057qib7 869 4 evidence evidence NN cord-005453-4057qib7 869 5 of of IN cord-005453-4057qib7 869 6 the the DT cord-005453-4057qib7 869 7 efficacy efficacy NN cord-005453-4057qib7 869 8 of of IN cord-005453-4057qib7 869 9 highdose highdose NN cord-005453-4057qib7 869 10 chemotherapy chemotherapy NN cord-005453-4057qib7 869 11 followed follow VBN cord-005453-4057qib7 869 12 by by IN cord-005453-4057qib7 869 13 autologous autologous JJ cord-005453-4057qib7 869 14 haematopoietic haematopoietic JJ cord-005453-4057qib7 869 15 stem stem NN cord-005453-4057qib7 869 16 cell cell NN cord-005453-4057qib7 869 17 transplantation(aHSCT transplantation(aHSCT NNP cord-005453-4057qib7 869 18 ) ) -RRB- cord-005453-4057qib7 869 19 in in IN cord-005453-4057qib7 869 20 MS MS NNP cord-005453-4057qib7 869 21 patients patient NNS cord-005453-4057qib7 869 22 who who WP cord-005453-4057qib7 869 23 failed fail VBD cord-005453-4057qib7 869 24 response response NN cord-005453-4057qib7 869 25 to to IN cord-005453-4057qib7 869 26 standard standard JJ cord-005453-4057qib7 869 27 immunotherapy immunotherapy NN cord-005453-4057qib7 869 28 , , , cord-005453-4057qib7 869 29 despite despite IN cord-005453-4057qib7 869 30 a a DT cord-005453-4057qib7 869 31 variability variability NN cord-005453-4057qib7 869 32 in in IN cord-005453-4057qib7 869 33 eligibility eligibility NN cord-005453-4057qib7 869 34 criteria criterion NNS cord-005453-4057qib7 869 35 , , , cord-005453-4057qib7 869 36 conditioning conditioning NN cord-005453-4057qib7 869 37 regimens regimen NNS cord-005453-4057qib7 869 38 and and CC cord-005453-4057qib7 869 39 outcome outcome NN cord-005453-4057qib7 869 40 . . . cord-005453-4057qib7 870 1 Methods method NNS cord-005453-4057qib7 871 1 : : : cord-005453-4057qib7 871 2 We -PRON- PRP cord-005453-4057qib7 871 3 retrospectively retrospectively RB cord-005453-4057qib7 871 4 reviewed review VBD cord-005453-4057qib7 871 5 MS MS NNP cord-005453-4057qib7 871 6 patients patient NNS cord-005453-4057qib7 871 7 submitted submit VBN cord-005453-4057qib7 871 8 to to IN cord-005453-4057qib7 871 9 aHSCT ahsct VB cord-005453-4057qib7 871 10 in in IN cord-005453-4057qib7 871 11 our -PRON- PRP$ cord-005453-4057qib7 871 12 centre centre NN cord-005453-4057qib7 871 13 ( ( -LRB- cord-005453-4057qib7 871 14 2014 2014 CD cord-005453-4057qib7 871 15 ) ) -RRB- cord-005453-4057qib7 871 16 ( ( -LRB- cord-005453-4057qib7 871 17 2015 2015 CD cord-005453-4057qib7 871 18 ) ) -RRB- cord-005453-4057qib7 871 19 ( ( -LRB- cord-005453-4057qib7 871 20 2016 2016 CD cord-005453-4057qib7 871 21 ) ) -RRB- cord-005453-4057qib7 871 22 ( ( -LRB- cord-005453-4057qib7 871 23 2017 2017 CD cord-005453-4057qib7 871 24 ) ) -RRB- cord-005453-4057qib7 871 25 ( ( -LRB- cord-005453-4057qib7 871 26 2018 2018 CD cord-005453-4057qib7 871 27 ) ) -RRB- cord-005453-4057qib7 871 28 . . . cord-005453-4057qib7 872 1 Patient patient JJ cord-005453-4057qib7 872 2 eligibility eligibility NN cord-005453-4057qib7 872 3 criteria criterion NNS cord-005453-4057qib7 872 4 were be VBD cord-005453-4057qib7 872 5 active active JJ cord-005453-4057qib7 872 6 relapsing relapse VBG cord-005453-4057qib7 872 7 remitting(RRMS remitting(RRMS -LRB- cord-005453-4057qib7 872 8 ) ) -RRB- cord-005453-4057qib7 872 9 or or CC cord-005453-4057qib7 872 10 secondary secondary JJ cord-005453-4057qib7 872 11 - - HYPH cord-005453-4057qib7 872 12 progressive progressive JJ cord-005453-4057qib7 872 13 MS MS NNP cord-005453-4057qib7 872 14 ( ( -LRB- cord-005453-4057qib7 872 15 SPMS SPMS NNP cord-005453-4057qib7 872 16 ) ) -RRB- cord-005453-4057qib7 872 17 , , , cord-005453-4057qib7 872 18 with with IN cord-005453-4057qib7 872 19 prior prior JJ cord-005453-4057qib7 872 20 failure failure NN cord-005453-4057qib7 872 21 to to IN cord-005453-4057qib7 872 22 treatment treatment NN cord-005453-4057qib7 872 23 with with IN cord-005453-4057qib7 872 24 disease disease NN cord-005453-4057qib7 872 25 - - HYPH cord-005453-4057qib7 872 26 modifying modify VBG cord-005453-4057qib7 872 27 therapies therapy NNS cord-005453-4057qib7 872 28 and and CC cord-005453-4057qib7 872 29 evidence evidence NN cord-005453-4057qib7 872 30 of of IN cord-005453-4057qib7 872 31 disease disease NN cord-005453-4057qib7 872 32 activity activity NN cord-005453-4057qib7 872 33 ( ( -LRB- cord-005453-4057qib7 872 34 clinical clinical JJ cord-005453-4057qib7 872 35 relapse relapse NN cord-005453-4057qib7 872 36 or or CC cord-005453-4057qib7 872 37 new new JJ cord-005453-4057qib7 872 38 active active JJ cord-005453-4057qib7 872 39 lesions lesion NNS cord-005453-4057qib7 872 40 in in IN cord-005453-4057qib7 872 41 magnetic magnetic JJ cord-005453-4057qib7 872 42 resonance resonance NN cord-005453-4057qib7 872 43 [ [ -LRB- cord-005453-4057qib7 872 44 MR MR NNP cord-005453-4057qib7 872 45 ] ] -RRB- cord-005453-4057qib7 872 46 ) ) -RRB- cord-005453-4057qib7 872 47 . . . cord-005453-4057qib7 873 1 Mobilization mobilization NN cord-005453-4057qib7 873 2 of of IN cord-005453-4057qib7 873 3 CD34+cells CD34+cells NNPS cord-005453-4057qib7 873 4 to to IN cord-005453-4057qib7 873 5 peripheral peripheral JJ cord-005453-4057qib7 873 6 blood blood NN cord-005453-4057qib7 873 7 was be VBD cord-005453-4057qib7 873 8 performed perform VBN cord-005453-4057qib7 873 9 with with IN cord-005453-4057qib7 873 10 granulocyte granulocyte NNP cord-005453-4057qib7 873 11 colony colony NN cord-005453-4057qib7 873 12 - - HYPH cord-005453-4057qib7 873 13 stimulating stimulate VBG cord-005453-4057qib7 873 14 factor(G factor(G NNP cord-005453-4057qib7 873 15 - - HYPH cord-005453-4057qib7 873 16 CSF CSF NNP cord-005453-4057qib7 873 17 10μg 10μg NN cord-005453-4057qib7 873 18 / / SYM cord-005453-4057qib7 873 19 kg kg NN cord-005453-4057qib7 873 20 / / SYM cord-005453-4057qib7 873 21 day day NN cord-005453-4057qib7 873 22 ) ) -RRB- cord-005453-4057qib7 873 23 and and CC cord-005453-4057qib7 873 24 conditioning conditioning NN cord-005453-4057qib7 873 25 regimen regimen NN cord-005453-4057qib7 873 26 according accord VBG cord-005453-4057qib7 873 27 to to IN cord-005453-4057qib7 873 28 BEAM beam NN cord-005453-4057qib7 873 29 protocol protocol NN cord-005453-4057qib7 873 30 . . . cord-005453-4057qib7 874 1 The the DT cord-005453-4057qib7 874 2 severity severity NN cord-005453-4057qib7 874 3 of of IN cord-005453-4057qib7 874 4 MS MS NNP cord-005453-4057qib7 874 5 disability disability NN cord-005453-4057qib7 874 6 was be VBD cord-005453-4057qib7 874 7 classified classify VBN cord-005453-4057qib7 874 8 according accord VBG cord-005453-4057qib7 874 9 to to IN cord-005453-4057qib7 874 10 the the DT cord-005453-4057qib7 874 11 Expanded Expanded NNP cord-005453-4057qib7 874 12 Disability Disability NNP cord-005453-4057qib7 874 13 - - HYPH cord-005453-4057qib7 874 14 Status Status NNP cord-005453-4057qib7 874 15 Scale scale NN cord-005453-4057qib7 874 16 ( ( -LRB- cord-005453-4057qib7 874 17 EDSS EDSS NNP cord-005453-4057qib7 874 18 ) ) -RRB- cord-005453-4057qib7 874 19 and and CC cord-005453-4057qib7 874 20 aHSCT ahsct JJ cord-005453-4057qib7 874 21 toxicity toxicity NN cord-005453-4057qib7 874 22 was be VBD cord-005453-4057qib7 874 23 evaluated evaluate VBN cord-005453-4057qib7 874 24 by by IN cord-005453-4057qib7 874 25 CTCAEv5.0 CTCAEv5.0 NNP cord-005453-4057qib7 874 26 . . . cord-005453-4057qib7 875 1 Results result NNS cord-005453-4057qib7 875 2 : : : cord-005453-4057qib7 876 1 Seven seven CD cord-005453-4057qib7 876 2 MS MS NNP cord-005453-4057qib7 876 3 patients patient NNS cord-005453-4057qib7 876 4 had have VBD cord-005453-4057qib7 876 5 undergone undergo VBN cord-005453-4057qib7 876 6 aHSCT ahsct NN cord-005453-4057qib7 876 7 ( ( -LRB- cord-005453-4057qib7 876 8 4 4 CD cord-005453-4057qib7 876 9 female/3 female/3 NNP cord-005453-4057qib7 876 10 male male NNP cord-005453-4057qib7 876 11 ) ) -RRB- cord-005453-4057qib7 876 12 , , , cord-005453-4057qib7 876 13 with with IN cord-005453-4057qib7 876 14 a a DT cord-005453-4057qib7 876 15 median median JJ cord-005453-4057qib7 876 16 age age NN cord-005453-4057qib7 876 17 at at IN cord-005453-4057qib7 876 18 aHSCT ahsct NN cord-005453-4057qib7 876 19 of of IN cord-005453-4057qib7 876 20 39.9 39.9 CD cord-005453-4057qib7 876 21 years year NNS cord-005453-4057qib7 876 22 ( ( -LRB- cord-005453-4057qib7 876 23 32 32 CD cord-005453-4057qib7 876 24 ) ) -RRB- cord-005453-4057qib7 877 1 ( ( -LRB- cord-005453-4057qib7 877 2 33 33 CD cord-005453-4057qib7 877 3 ) ) -RRB- cord-005453-4057qib7 878 1 ( ( -LRB- cord-005453-4057qib7 878 2 34 34 CD cord-005453-4057qib7 878 3 ) ) -RRB- cord-005453-4057qib7 879 1 ( ( -LRB- cord-005453-4057qib7 879 2 35 35 CD cord-005453-4057qib7 879 3 ) ) -RRB- cord-005453-4057qib7 879 4 ( ( -LRB- cord-005453-4057qib7 879 5 36 36 CD cord-005453-4057qib7 879 6 ) ) -RRB- cord-005453-4057qib7 879 7 ( ( -LRB- cord-005453-4057qib7 879 8 37 37 CD cord-005453-4057qib7 879 9 ) ) -RRB- cord-005453-4057qib7 880 1 ( ( -LRB- cord-005453-4057qib7 880 2 38 38 CD cord-005453-4057qib7 880 3 ) ) -RRB- cord-005453-4057qib7 881 1 ( ( -LRB- cord-005453-4057qib7 881 2 39 39 CD cord-005453-4057qib7 881 3 ) ) -RRB- cord-005453-4057qib7 882 1 ( ( -LRB- cord-005453-4057qib7 882 2 40 40 CD cord-005453-4057qib7 882 3 ) ) -RRB- cord-005453-4057qib7 882 4 ( ( -LRB- cord-005453-4057qib7 882 5 41 41 CD cord-005453-4057qib7 882 6 ) ) -RRB- cord-005453-4057qib7 882 7 ( ( -LRB- cord-005453-4057qib7 882 8 42 42 CD cord-005453-4057qib7 882 9 ) ) -RRB- cord-005453-4057qib7 882 10 . . . cord-005453-4057qib7 883 1 Median median JJ cord-005453-4057qib7 883 2 age age NN cord-005453-4057qib7 883 3 at at IN cord-005453-4057qib7 883 4 MS MS NNP cord-005453-4057qib7 883 5 diagnosis diagnosis NN cord-005453-4057qib7 883 6 was be VBD cord-005453-4057qib7 883 7 31.6 31.6 CD cord-005453-4057qib7 883 8 years(27 years(27 NNP cord-005453-4057qib7 883 9 - - HYPH cord-005453-4057qib7 883 10 36 36 CD cord-005453-4057qib7 883 11 ) ) -RRB- cord-005453-4057qib7 883 12 and and CC cord-005453-4057qib7 883 13 median median JJ cord-005453-4057qib7 883 14 time time NN cord-005453-4057qib7 883 15 from from IN cord-005453-4057qib7 883 16 diagnosis diagnosis NN cord-005453-4057qib7 883 17 until until IN cord-005453-4057qib7 883 18 aHSCT aHSCT NNP cord-005453-4057qib7 883 19 was be VBD cord-005453-4057qib7 883 20 6.8 6.8 CD cord-005453-4057qib7 883 21 years year NNS cord-005453-4057qib7 883 22 ( ( -LRB- cord-005453-4057qib7 883 23 3 3 LS cord-005453-4057qib7 883 24 ) ) -RRB- cord-005453-4057qib7 883 25 ( ( -LRB- cord-005453-4057qib7 883 26 4 4 LS cord-005453-4057qib7 883 27 ) ) -RRB- cord-005453-4057qib7 883 28 ( ( -LRB- cord-005453-4057qib7 883 29 5 5 LS cord-005453-4057qib7 883 30 ) ) -RRB- cord-005453-4057qib7 883 31 ( ( -LRB- cord-005453-4057qib7 883 32 6 6 LS cord-005453-4057qib7 883 33 ) ) -RRB- cord-005453-4057qib7 883 34 ( ( -LRB- cord-005453-4057qib7 883 35 7 7 LS cord-005453-4057qib7 883 36 ) ) -RRB- cord-005453-4057qib7 883 37 ( ( -LRB- cord-005453-4057qib7 883 38 8) 8) NNP cord-005453-4057qib7 883 39 ( ( -LRB- cord-005453-4057qib7 883 40 9 9 CD cord-005453-4057qib7 883 41 ) ) -RRB- cord-005453-4057qib7 883 42 ( ( -LRB- cord-005453-4057qib7 883 43 10 10 CD cord-005453-4057qib7 883 44 ) ) -RRB- cord-005453-4057qib7 883 45 ( ( -LRB- cord-005453-4057qib7 883 46 11 11 CD cord-005453-4057qib7 883 47 ) ) -RRB- cord-005453-4057qib7 883 48 ( ( -LRB- cord-005453-4057qib7 883 49 12 12 CD cord-005453-4057qib7 883 50 ) ) -RRB- cord-005453-4057qib7 883 51 ( ( -LRB- cord-005453-4057qib7 883 52 13 13 CD cord-005453-4057qib7 883 53 ) ) -RRB- cord-005453-4057qib7 883 54 . . . cord-005453-4057qib7 884 1 Four four CD cord-005453-4057qib7 884 2 patients patient NNS cord-005453-4057qib7 884 3 ( ( -LRB- cord-005453-4057qib7 884 4 57.1 57.1 CD cord-005453-4057qib7 884 5 % % NN cord-005453-4057qib7 884 6 ) ) -RRB- cord-005453-4057qib7 884 7 had have VBD cord-005453-4057qib7 884 8 SPMS SPMS NNP cord-005453-4057qib7 884 9 and and CC cord-005453-4057qib7 884 10 3(42.9 3(42.9 CD cord-005453-4057qib7 884 11 % % NN cord-005453-4057qib7 884 12 ) ) -RRB- cord-005453-4057qib7 884 13 had have VBD cord-005453-4057qib7 884 14 RRMS rrm NNS cord-005453-4057qib7 884 15 , , , cord-005453-4057qib7 884 16 with with IN cord-005453-4057qib7 884 17 4(57.1 4(57.1 CD cord-005453-4057qib7 884 18 % % NN cord-005453-4057qib7 884 19 ) ) -RRB- cord-005453-4057qib7 884 20 having have VBG cord-005453-4057qib7 884 21 MR MR NNP cord-005453-4057qib7 884 22 active active JJ cord-005453-4057qib7 884 23 lesions lesion NNS cord-005453-4057qib7 884 24 . . . cord-005453-4057qib7 885 1 Pre pre JJ cord-005453-4057qib7 885 2 - - JJ cord-005453-4057qib7 885 3 aHSCT ahsct JJ cord-005453-4057qib7 885 4 relapse relapse NN cord-005453-4057qib7 885 5 rate rate NN cord-005453-4057qib7 885 6 per per IN cord-005453-4057qib7 885 7 year year NN cord-005453-4057qib7 885 8 was be VBD cord-005453-4057qib7 885 9 2 2 CD cord-005453-4057qib7 885 10 ( ( -LRB- cord-005453-4057qib7 885 11 1 1 CD cord-005453-4057qib7 885 12 ) ) -RRB- cord-005453-4057qib7 885 13 ( ( -LRB- cord-005453-4057qib7 885 14 2 2 LS cord-005453-4057qib7 885 15 ) ) -RRB- cord-005453-4057qib7 885 16 ( ( -LRB- cord-005453-4057qib7 885 17 3 3 LS cord-005453-4057qib7 885 18 ) ) -RRB- cord-005453-4057qib7 885 19 ( ( -LRB- cord-005453-4057qib7 885 20 4 4 LS cord-005453-4057qib7 885 21 ) ) -RRB- cord-005453-4057qib7 885 22 . . . cord-005453-4057qib7 886 1 Median median JJ cord-005453-4057qib7 886 2 baseline baseline JJ cord-005453-4057qib7 886 3 EDSS EDSS NNP cord-005453-4057qib7 886 4 was be VBD cord-005453-4057qib7 886 5 6.5(5.5 6.5(5.5 CD cord-005453-4057qib7 886 6 - - SYM cord-005453-4057qib7 886 7 7.5 7.5 CD cord-005453-4057qib7 886 8 ) ) -RRB- cord-005453-4057qib7 886 9 . . . cord-005453-4057qib7 887 1 Median median JJ cord-005453-4057qib7 887 2 number number NN cord-005453-4057qib7 887 3 of of IN cord-005453-4057qib7 887 4 previous previous JJ cord-005453-4057qib7 887 5 DMTs dmt NNS cord-005453-4057qib7 887 6 was be VBD cord-005453-4057qib7 887 7 6 6 CD cord-005453-4057qib7 887 8 ( ( -LRB- cord-005453-4057qib7 887 9 3 3 CD cord-005453-4057qib7 887 10 ) ) -RRB- cord-005453-4057qib7 887 11 ( ( -LRB- cord-005453-4057qib7 887 12 4 4 LS cord-005453-4057qib7 887 13 ) ) -RRB- cord-005453-4057qib7 887 14 ( ( -LRB- cord-005453-4057qib7 887 15 5 5 LS cord-005453-4057qib7 887 16 ) ) -RRB- cord-005453-4057qib7 887 17 ( ( -LRB- cord-005453-4057qib7 887 18 6 6 LS cord-005453-4057qib7 887 19 ) ) -RRB- cord-005453-4057qib7 887 20 ( ( -LRB- cord-005453-4057qib7 887 21 7 7 LS cord-005453-4057qib7 887 22 ) ) -RRB- cord-005453-4057qib7 887 23 ( ( -LRB- cord-005453-4057qib7 887 24 8) 8) NNP cord-005453-4057qib7 887 25 ( ( -LRB- cord-005453-4057qib7 887 26 9 9 CD cord-005453-4057qib7 887 27 ) ) -RRB- cord-005453-4057qib7 887 28 . . . cord-005453-4057qib7 888 1 All all DT cord-005453-4057qib7 888 2 patients patient NNS cord-005453-4057qib7 888 3 had have VBD cord-005453-4057qib7 888 4 been be VBN cord-005453-4057qib7 888 5 treated treat VBN cord-005453-4057qib7 888 6 with with IN cord-005453-4057qib7 888 7 corticosteroids corticosteroid NNS cord-005453-4057qib7 888 8 and and CC cord-005453-4057qib7 888 9 copaxone copaxone NNP cord-005453-4057qib7 888 10 , , , cord-005453-4057qib7 888 11 5(71.4 5(71.4 CD cord-005453-4057qib7 888 12 % % NN cord-005453-4057qib7 888 13 ) ) -RRB- cord-005453-4057qib7 888 14 received receive VBD cord-005453-4057qib7 888 15 rituximab rituximab NN cord-005453-4057qib7 888 16 , , , cord-005453-4057qib7 888 17 6 6 CD cord-005453-4057qib7 888 18 ( ( -LRB- cord-005453-4057qib7 888 19 85.7 85.7 CD cord-005453-4057qib7 888 20 % % NN cord-005453-4057qib7 888 21 ) ) -RRB- cord-005453-4057qib7 888 22 natalizumab natalizumab NNS cord-005453-4057qib7 888 23 , , , cord-005453-4057qib7 888 24 1 1 CD cord-005453-4057qib7 888 25 ( ( -LRB- cord-005453-4057qib7 888 26 14.3 14.3 CD cord-005453-4057qib7 888 27 % % NN cord-005453-4057qib7 888 28 ) ) -RRB- cord-005453-4057qib7 888 29 alemtuzumab alemtuzumab NNP cord-005453-4057qib7 888 30 , , , cord-005453-4057qib7 888 31 2(28.6 2(28.6 CD cord-005453-4057qib7 888 32 % % NN cord-005453-4057qib7 888 33 ) ) -RRB- cord-005453-4057qib7 888 34 fampridine fampridine NN cord-005453-4057qib7 888 35 and and CC cord-005453-4057qib7 888 36 2(28.6 2(28.6 CD cord-005453-4057qib7 888 37 % % NN cord-005453-4057qib7 888 38 ) ) -RRB- cord-005453-4057qib7 888 39 fingolimod fingolimod NNP cord-005453-4057qib7 888 40 . . . cord-005453-4057qib7 889 1 All all DT cord-005453-4057qib7 889 2 patients patient NNS cord-005453-4057qib7 889 3 collected collect VBD cord-005453-4057qib7 889 4 enough enough JJ cord-005453-4057qib7 889 5 CD34 CD34 NNP cord-005453-4057qib7 889 6 + + CC cord-005453-4057qib7 889 7 cells cell NNS cord-005453-4057qib7 889 8 in in IN cord-005453-4057qib7 889 9 a a DT cord-005453-4057qib7 889 10 single single JJ cord-005453-4057qib7 889 11 apheresis apheresis NN cord-005453-4057qib7 889 12 session session NN cord-005453-4057qib7 889 13 . . . cord-005453-4057qib7 890 1 Median median JJ cord-005453-4057qib7 890 2 number number NN cord-005453-4057qib7 890 3 of of IN cord-005453-4057qib7 890 4 CD34 CD34 NNP cord-005453-4057qib7 890 5 + + CC cord-005453-4057qib7 890 6 cells cell NNS cord-005453-4057qib7 890 7 infused infuse VBN cord-005453-4057qib7 890 8 was be VBD cord-005453-4057qib7 890 9 7.2±3.8x10 7.2±3.8x10 CD cord-005453-4057qib7 890 10 ^ ^ SYM cord-005453-4057qib7 890 11 6 6 CD cord-005453-4057qib7 890 12 / / SYM cord-005453-4057qib7 890 13 kg kg NNS cord-005453-4057qib7 890 14 , , , cord-005453-4057qib7 890 15 for for IN cord-005453-4057qib7 890 16 a a DT cord-005453-4057qib7 890 17 mean mean JJ cord-005453-4057qib7 890 18 DMSO DMSO NNP cord-005453-4057qib7 890 19 volume volume NN cord-005453-4057qib7 890 20 of of IN cord-005453-4057qib7 890 21 50.4 50.4 CD cord-005453-4057qib7 890 22 ±14.8 ±14.8 NNP cord-005453-4057qib7 890 23 mL. mL. . cord-005453-4057qib7 890 24 Median median JJ cord-005453-4057qib7 890 25 inpatient inpatient JJ cord-005453-4057qib7 890 26 stay stay NN cord-005453-4057qib7 890 27 during during IN cord-005453-4057qib7 890 28 aHSCT ahsct NN cord-005453-4057qib7 891 1 was be VBD cord-005453-4057qib7 891 2 28 28 CD cord-005453-4057qib7 892 1 days(21 days(21 NNP cord-005453-4057qib7 892 2 - - : cord-005453-4057qib7 892 3 47 47 CD cord-005453-4057qib7 892 4 ) ) -RRB- cord-005453-4057qib7 892 5 . . . cord-005453-4057qib7 893 1 All all DT cord-005453-4057qib7 893 2 patients patient NNS cord-005453-4057qib7 893 3 developed develop VBD cord-005453-4057qib7 893 4 febrile febrile JJ cord-005453-4057qib7 893 5 neutropenia neutropenia NN cord-005453-4057qib7 893 6 , , , cord-005453-4057qib7 893 7 one one CD cord-005453-4057qib7 893 8 was be VBD cord-005453-4057qib7 893 9 admitted admit VBN cord-005453-4057qib7 893 10 to to IN cord-005453-4057qib7 893 11 intensive intensive JJ cord-005453-4057qib7 893 12 care care NN cord-005453-4057qib7 893 13 unit unit NN cord-005453-4057qib7 893 14 due due JJ cord-005453-4057qib7 893 15 to to IN cord-005453-4057qib7 893 16 sepsis sepsis NN cord-005453-4057qib7 893 17 . . . cord-005453-4057qib7 894 1 One one CD cord-005453-4057qib7 894 2 patient patient NN cord-005453-4057qib7 894 3 developed develop VBD cord-005453-4057qib7 894 4 an an DT cord-005453-4057qib7 894 5 anaphylactic anaphylactic JJ cord-005453-4057qib7 894 6 reaction reaction NN cord-005453-4057qib7 894 7 to to IN cord-005453-4057qib7 894 8 transfusion transfusion NN cord-005453-4057qib7 894 9 and and CC cord-005453-4057qib7 894 10 another another DT cord-005453-4057qib7 894 11 a a DT cord-005453-4057qib7 894 12 self self NN cord-005453-4057qib7 894 13 - - HYPH cord-005453-4057qib7 894 14 limited limit VBN cord-005453-4057qib7 894 15 encephalopathy encephalopathy NN cord-005453-4057qib7 894 16 . . . cord-005453-4057qib7 895 1 Two two CD cord-005453-4057qib7 895 2 ( ( -LRB- cord-005453-4057qib7 895 3 28.7 28.7 CD cord-005453-4057qib7 895 4 % % NN cord-005453-4057qib7 895 5 ) ) -RRB- cord-005453-4057qib7 895 6 patients patient NNS cord-005453-4057qib7 895 7 had have VBD cord-005453-4057qib7 895 8 grade≥2 grade≥2 NNP cord-005453-4057qib7 895 9 oral oral JJ cord-005453-4057qib7 895 10 mucositis mucositis NN cord-005453-4057qib7 895 11 , , , cord-005453-4057qib7 895 12 and and CC cord-005453-4057qib7 895 13 all all DT cord-005453-4057qib7 895 14 had have VBD cord-005453-4057qib7 895 15 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 895 16 toxicity toxicity NN cord-005453-4057qib7 895 17 ( ( -LRB- cord-005453-4057qib7 895 18 grade grade NN cord-005453-4057qib7 895 19 2 2 CD cord-005453-4057qib7 895 20 - - SYM cord-005453-4057qib7 895 21 3 3 CD cord-005453-4057qib7 895 22 ) ) -RRB- cord-005453-4057qib7 895 23 . . . cord-005453-4057qib7 896 1 Median median JJ cord-005453-4057qib7 896 2 time time NN cord-005453-4057qib7 896 3 until until IN cord-005453-4057qib7 896 4 neutrophils>500 neutrophils>500 CD cord-005453-4057qib7 897 1 /μL /μL : cord-005453-4057qib7 897 2 was be VBD cord-005453-4057qib7 897 3 11(6 11(6 CD cord-005453-4057qib7 897 4 - - SYM cord-005453-4057qib7 897 5 12 12 CD cord-005453-4057qib7 897 6 ) ) -RRB- cord-005453-4057qib7 897 7 days day NNS cord-005453-4057qib7 897 8 , , , cord-005453-4057qib7 897 9 to to IN cord-005453-4057qib7 897 10 platelets>20,000 platelets>20,000 ADD cord-005453-4057qib7 898 1 /μL /μL : cord-005453-4057qib7 898 2 was be VBD cord-005453-4057qib7 898 3 9 9 CD cord-005453-4057qib7 898 4 days(5 days(5 CD cord-005453-4057qib7 898 5 - - SYM cord-005453-4057qib7 898 6 12 12 CD cord-005453-4057qib7 898 7 ) ) -RRB- cord-005453-4057qib7 898 8 , , , cord-005453-4057qib7 898 9 and and CC cord-005453-4057qib7 898 10 to to IN cord-005453-4057qib7 898 11 engraftment engraftment NNP cord-005453-4057qib7 898 12 was be VBD cord-005453-4057qib7 898 13 13 13 CD cord-005453-4057qib7 898 14 days day NNS cord-005453-4057qib7 898 15 ( ( -LRB- cord-005453-4057qib7 898 16 12 12 CD cord-005453-4057qib7 898 17 ) ) -RRB- cord-005453-4057qib7 899 1 ( ( -LRB- cord-005453-4057qib7 899 2 13 13 CD cord-005453-4057qib7 899 3 ) ) -RRB- cord-005453-4057qib7 899 4 ( ( -LRB- cord-005453-4057qib7 899 5 14 14 CD cord-005453-4057qib7 899 6 ) ) -RRB- cord-005453-4057qib7 899 7 . . . cord-005453-4057qib7 900 1 Patients patient NNS cord-005453-4057qib7 900 2 were be VBD cord-005453-4057qib7 900 3 transfused transfuse VBN cord-005453-4057qib7 900 4 with with IN cord-005453-4057qib7 900 5 a a DT cord-005453-4057qib7 900 6 median median NN cord-005453-4057qib7 900 7 of of IN cord-005453-4057qib7 900 8 1(0 1(0 CD cord-005453-4057qib7 900 9 - - SYM cord-005453-4057qib7 900 10 2 2 CD cord-005453-4057qib7 900 11 ) ) -RRB- cord-005453-4057qib7 900 12 unit unit NN cord-005453-4057qib7 900 13 for for IN cord-005453-4057qib7 900 14 erythrocytes erythrocyte NNS cord-005453-4057qib7 900 15 and and CC cord-005453-4057qib7 900 16 3(1 3(1 NNP cord-005453-4057qib7 900 17 - - HYPH cord-005453-4057qib7 900 18 8 8 CD cord-005453-4057qib7 900 19 ) ) -RRB- cord-005453-4057qib7 900 20 for for IN cord-005453-4057qib7 900 21 platelets platelet NNS cord-005453-4057qib7 900 22 . . . cord-005453-4057qib7 901 1 There there EX cord-005453-4057qib7 901 2 was be VBD cord-005453-4057qib7 902 1 no no DT cord-005453-4057qib7 902 2 treatment treatment NN cord-005453-4057qib7 902 3 - - HYPH cord-005453-4057qib7 902 4 related relate VBN cord-005453-4057qib7 902 5 mortality mortality NN cord-005453-4057qib7 902 6 and and CC cord-005453-4057qib7 902 7 no no DT cord-005453-4057qib7 902 8 long long JJ cord-005453-4057qib7 902 9 term term NN cord-005453-4057qib7 902 10 side side NN cord-005453-4057qib7 902 11 effects effect NNS cord-005453-4057qib7 902 12 have have VBP cord-005453-4057qib7 902 13 been be VBN cord-005453-4057qib7 902 14 observed observe VBN cord-005453-4057qib7 902 15 so so RB cord-005453-4057qib7 902 16 far far RB cord-005453-4057qib7 902 17 . . . cord-005453-4057qib7 903 1 For for IN cord-005453-4057qib7 903 2 a a DT cord-005453-4057qib7 903 3 median median JJ cord-005453-4057qib7 903 4 post post JJ cord-005453-4057qib7 903 5 - - JJ cord-005453-4057qib7 903 6 aHSCT ahsct JJ cord-005453-4057qib7 903 7 follow follow NN cord-005453-4057qib7 903 8 - - HYPH cord-005453-4057qib7 903 9 up up NN cord-005453-4057qib7 903 10 of of IN cord-005453-4057qib7 903 11 8.7 8.7 CD cord-005453-4057qib7 903 12 months month NNS cord-005453-4057qib7 903 13 , , , cord-005453-4057qib7 903 14 no no DT cord-005453-4057qib7 903 15 patient patient NN cord-005453-4057qib7 903 16 developed develop VBD cord-005453-4057qib7 903 17 new new JJ cord-005453-4057qib7 903 18 lesions lesion NNS cord-005453-4057qib7 903 19 in in IN cord-005453-4057qib7 903 20 MR MR NNP cord-005453-4057qib7 903 21 , , , cord-005453-4057qib7 903 22 but but CC cord-005453-4057qib7 903 23 2(28.6 2(28.6 CD cord-005453-4057qib7 903 24 % % NN cord-005453-4057qib7 903 25 ) ) -RRB- cord-005453-4057qib7 903 26 experienced experience VBN cord-005453-4057qib7 903 27 symptoms symptom NNS cord-005453-4057qib7 903 28 consistent consistent JJ cord-005453-4057qib7 903 29 with with IN cord-005453-4057qib7 903 30 a a DT cord-005453-4057qib7 903 31 clinical clinical JJ cord-005453-4057qib7 903 32 relapse relapse NN cord-005453-4057qib7 903 33 , , , cord-005453-4057qib7 903 34 at at IN cord-005453-4057qib7 903 35 a a DT cord-005453-4057qib7 903 36 median median JJ cord-005453-4057qib7 903 37 time time NN cord-005453-4057qib7 903 38 of of IN cord-005453-4057qib7 903 39 20.5(5 20.5(5 CD cord-005453-4057qib7 903 40 - - SYM cord-005453-4057qib7 903 41 35 35 CD cord-005453-4057qib7 903 42 ) ) -RRB- cord-005453-4057qib7 903 43 months month NNS cord-005453-4057qib7 903 44 , , , cord-005453-4057qib7 903 45 effectively effectively RB cord-005453-4057qib7 903 46 rescued rescue VBN cord-005453-4057qib7 903 47 with with IN cord-005453-4057qib7 903 48 corticosteroids corticosteroid NNS cord-005453-4057qib7 903 49 . . . cord-005453-4057qib7 904 1 The the DT cord-005453-4057qib7 904 2 absence absence NN cord-005453-4057qib7 904 3 of of IN cord-005453-4057qib7 904 4 evidence evidence NN cord-005453-4057qib7 904 5 of of IN cord-005453-4057qib7 904 6 disease disease NN cord-005453-4057qib7 904 7 activity activity NN cord-005453-4057qib7 904 8 at at IN cord-005453-4057qib7 904 9 6-months 6-months CD cord-005453-4057qib7 904 10 was be VBD cord-005453-4057qib7 904 11 71.4 71.4 CD cord-005453-4057qib7 904 12 % % NN cord-005453-4057qib7 904 13 . . . cord-005453-4057qib7 905 1 Although although IN cord-005453-4057qib7 905 2 there there EX cord-005453-4057qib7 905 3 was be VBD cord-005453-4057qib7 905 4 no no DT cord-005453-4057qib7 905 5 variation variation NN cord-005453-4057qib7 905 6 concerning concern VBG cord-005453-4057qib7 905 7 EDSS EDSS NNP cord-005453-4057qib7 905 8 punctuation punctuation NN cord-005453-4057qib7 905 9 , , , cord-005453-4057qib7 905 10 4(57.1 4(57.1 CD cord-005453-4057qib7 905 11 % % NN cord-005453-4057qib7 905 12 ) ) -RRB- cord-005453-4057qib7 905 13 patients patient NNS cord-005453-4057qib7 905 14 self self NN cord-005453-4057qib7 905 15 - - HYPH cord-005453-4057qib7 905 16 reported report VBN cord-005453-4057qib7 905 17 significant significant JJ cord-005453-4057qib7 905 18 benefits benefit NNS cord-005453-4057qib7 905 19 , , , cord-005453-4057qib7 905 20 especially especially RB cord-005453-4057qib7 905 21 concerning concern VBG cord-005453-4057qib7 905 22 limb limb NN cord-005453-4057qib7 905 23 strength strength NN cord-005453-4057qib7 905 24 and and CC cord-005453-4057qib7 905 25 sphincter sphincter NN cord-005453-4057qib7 905 26 continence continence NN cord-005453-4057qib7 905 27 improving improve VBG cord-005453-4057qib7 905 28 . . . cord-005453-4057qib7 906 1 Conclusions conclusion NNS cord-005453-4057qib7 906 2 : : : cord-005453-4057qib7 907 1 Our -PRON- PRP$ cord-005453-4057qib7 907 2 real real JJ cord-005453-4057qib7 907 3 life life NN cord-005453-4057qib7 907 4 results result NNS cord-005453-4057qib7 907 5 claim claim VBP cord-005453-4057qib7 907 6 a a DT cord-005453-4057qib7 907 7 stabilization stabilization NN cord-005453-4057qib7 907 8 effect effect NN cord-005453-4057qib7 907 9 of of IN cord-005453-4057qib7 907 10 MS MS NNP cord-005453-4057qib7 907 11 patients patient NNS cord-005453-4057qib7 907 12 with with IN cord-005453-4057qib7 907 13 highly highly RB cord-005453-4057qib7 907 14 active active JJ cord-005453-4057qib7 907 15 / / SYM cord-005453-4057qib7 907 16 progressive progressive JJ cord-005453-4057qib7 907 17 disease disease NN cord-005453-4057qib7 907 18 after after IN cord-005453-4057qib7 907 19 aHSCT aHSCT NNP cord-005453-4057qib7 907 20 , , , cord-005453-4057qib7 907 21 with with IN cord-005453-4057qib7 907 22 no no DT cord-005453-4057qib7 907 23 significant significant JJ cord-005453-4057qib7 907 24 toxicity toxicity NN cord-005453-4057qib7 907 25 . . . cord-005453-4057qib7 908 1 The the DT cord-005453-4057qib7 908 2 failure failure NN cord-005453-4057qib7 908 3 in in IN cord-005453-4057qib7 908 4 reporting report VBG cord-005453-4057qib7 908 5 benefits benefit NNS cord-005453-4057qib7 908 6 in in IN cord-005453-4057qib7 908 7 EDSS EDSS NNP cord-005453-4057qib7 908 8 punctuation punctuation NN cord-005453-4057qib7 908 9 is be VBZ cord-005453-4057qib7 908 10 probably probably RB cord-005453-4057qib7 908 11 due due JJ cord-005453-4057qib7 908 12 to to IN cord-005453-4057qib7 908 13 a a DT cord-005453-4057qib7 908 14 small small JJ cord-005453-4057qib7 908 15 sample sample NN cord-005453-4057qib7 908 16 size size NN cord-005453-4057qib7 908 17 and and CC cord-005453-4057qib7 908 18 short short JJ cord-005453-4057qib7 908 19 follow follow NN cord-005453-4057qib7 908 20 - - HYPH cord-005453-4057qib7 908 21 up up NN cord-005453-4057qib7 908 22 . . . cord-005453-4057qib7 909 1 More More JJR cord-005453-4057qib7 909 2 studies study NNS cord-005453-4057qib7 909 3 are be VBP cord-005453-4057qib7 909 4 needed need VBN cord-005453-4057qib7 909 5 to to TO cord-005453-4057qib7 909 6 establish establish VB cord-005453-4057qib7 909 7 the the DT cord-005453-4057qib7 909 8 best good JJS cord-005453-4057qib7 909 9 patient patient NN cord-005453-4057qib7 909 10 selection selection NN cord-005453-4057qib7 909 11 criteria criterion NNS cord-005453-4057qib7 909 12 and and CC cord-005453-4057qib7 909 13 define define VB cord-005453-4057qib7 909 14 the the DT cord-005453-4057qib7 909 15 ideal ideal JJ cord-005453-4057qib7 909 16 time time NN cord-005453-4057qib7 909 17 to to TO cord-005453-4057qib7 909 18 include include VB cord-005453-4057qib7 909 19 these these DT cord-005453-4057qib7 909 20 patients patient NNS cord-005453-4057qib7 909 21 in in IN cord-005453-4057qib7 909 22 transplantation transplantation NN cord-005453-4057qib7 909 23 programs program NNS cord-005453-4057qib7 909 24 , , , cord-005453-4057qib7 909 25 as as RB cord-005453-4057qib7 909 26 well well RB cord-005453-4057qib7 909 27 as as IN cord-005453-4057qib7 909 28 to to TO cord-005453-4057qib7 909 29 evaluate evaluate VB cord-005453-4057qib7 909 30 its -PRON- PRP$ cord-005453-4057qib7 909 31 long long JJ cord-005453-4057qib7 909 32 term term NN cord-005453-4057qib7 909 33 outcome outcome NN cord-005453-4057qib7 909 34 . . . cord-005453-4057qib7 910 1 Disclosure disclosure NN cord-005453-4057qib7 910 2 : : : cord-005453-4057qib7 910 3 Nothing nothing NN cord-005453-4057qib7 910 4 to to TO cord-005453-4057qib7 910 5 declare declare VB cord-005453-4057qib7 910 6 . . . cord-005453-4057qib7 911 1 Elena Elena NNP cord-005453-4057qib7 911 2 Poponina Poponina NNP cord-005453-4057qib7 911 3 1 1 CD cord-005453-4057qib7 911 4 , , , cord-005453-4057qib7 911 5 Elena Elena NNP cord-005453-4057qib7 911 6 Butina Butina NNP cord-005453-4057qib7 911 7 1 1 CD cord-005453-4057qib7 911 8 , , , cord-005453-4057qib7 911 9 Anna Anna NNP cord-005453-4057qib7 911 10 Yovdiy Yovdiy NNP cord-005453-4057qib7 911 11 1 1 CD cord-005453-4057qib7 911 12 , , , cord-005453-4057qib7 911 13 Galina Galina NNP cord-005453-4057qib7 911 14 Zaytseva Zaytseva NNP cord-005453-4057qib7 911 15 1 1 CD cord-005453-4057qib7 911 16 , , , cord-005453-4057qib7 911 17 Natalia Natalia NNP cord-005453-4057qib7 911 18 Minaeva Minaeva NNP cord-005453-4057qib7 911 19 1 1 CD cord-005453-4057qib7 911 20 , , , cord-005453-4057qib7 911 21 Igor Igor NNP cord-005453-4057qib7 911 22 Paramonov Paramonov NNP cord-005453-4057qib7 911 23 1 1 CD cord-005453-4057qib7 911 24 Background Background NNP cord-005453-4057qib7 911 25 : : : cord-005453-4057qib7 912 1 Reactivation reactivation NN cord-005453-4057qib7 912 2 of of IN cord-005453-4057qib7 912 3 Epstein Epstein NNP cord-005453-4057qib7 912 4 - - HYPH cord-005453-4057qib7 912 5 Barr Barr NNP cord-005453-4057qib7 912 6 virus virus NN cord-005453-4057qib7 912 7 ( ( -LRB- cord-005453-4057qib7 912 8 EBV EBV NNP cord-005453-4057qib7 912 9 ) ) -RRB- cord-005453-4057qib7 912 10 represents represent VBZ cord-005453-4057qib7 912 11 a a DT cord-005453-4057qib7 912 12 potentially potentially RB cord-005453-4057qib7 912 13 life life NN cord-005453-4057qib7 912 14 - - HYPH cord-005453-4057qib7 912 15 threatening threaten VBG cord-005453-4057qib7 912 16 condition condition NN cord-005453-4057qib7 912 17 in in IN cord-005453-4057qib7 912 18 approximately approximately RB cord-005453-4057qib7 912 19 30 30 CD cord-005453-4057qib7 912 20 % % NN cord-005453-4057qib7 912 21 of of IN cord-005453-4057qib7 912 22 patients patient NNS cord-005453-4057qib7 912 23 after after IN cord-005453-4057qib7 912 24 allogeneic allogeneic NN cord-005453-4057qib7 912 25 stem stem NN cord-005453-4057qib7 912 26 cell cell NN cord-005453-4057qib7 912 27 transplantation transplantation NN cord-005453-4057qib7 912 28 , , , cord-005453-4057qib7 912 29 with with IN cord-005453-4057qib7 912 30 no no DT cord-005453-4057qib7 912 31 specific specific JJ cord-005453-4057qib7 912 32 treatment treatment NN cord-005453-4057qib7 912 33 available available JJ cord-005453-4057qib7 912 34 . . . cord-005453-4057qib7 913 1 Methods method NNS cord-005453-4057qib7 913 2 : : : cord-005453-4057qib7 913 3 We -PRON- PRP cord-005453-4057qib7 913 4 have have VBP cord-005453-4057qib7 913 5 previously previously RB cord-005453-4057qib7 913 6 developed develop VBN cord-005453-4057qib7 913 7 a a DT cord-005453-4057qib7 913 8 manufacturing manufacturing NN cord-005453-4057qib7 913 9 protocol protocol NN cord-005453-4057qib7 913 10 for for IN cord-005453-4057qib7 913 11 the the DT cord-005453-4057qib7 913 12 expansion expansion NN cord-005453-4057qib7 913 13 of of IN cord-005453-4057qib7 913 14 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 913 15 ( ( -LRB- cord-005453-4057qib7 913 16 CMV CMV NNP cord-005453-4057qib7 913 17 ) ) -RRB- cord-005453-4057qib7 913 18 and and CC cord-005453-4057qib7 913 19 EBV EBV NNP cord-005453-4057qib7 913 20 - - HYPH cord-005453-4057qib7 913 21 specific specific JJ cord-005453-4057qib7 913 22 T t NN cord-005453-4057qib7 913 23 cells cell NNS cord-005453-4057qib7 913 24 by by IN cord-005453-4057qib7 913 25 stimulation stimulation NN cord-005453-4057qib7 913 26 of of IN cord-005453-4057qib7 913 27 G g NN cord-005453-4057qib7 913 28 - - HYPH cord-005453-4057qib7 913 29 CSFmobilized csfmobilize VBN cord-005453-4057qib7 913 30 stem stem NN cord-005453-4057qib7 913 31 cell cell NN cord-005453-4057qib7 913 32 grafts graft NNS cord-005453-4057qib7 913 33 with with IN cord-005453-4057qib7 913 34 defined define VBN cord-005453-4057qib7 913 35 peptide peptide NN cord-005453-4057qib7 913 36 pools pool NNS cord-005453-4057qib7 913 37 ( ( -LRB- cord-005453-4057qib7 913 38 Gary Gary NNP cord-005453-4057qib7 913 39 , , , cord-005453-4057qib7 913 40 2018 2018 CD cord-005453-4057qib7 913 41 ) ) -RRB- cord-005453-4057qib7 913 42 . . . cord-005453-4057qib7 914 1 This this DT cord-005453-4057qib7 914 2 Advanced Advanced NNP cord-005453-4057qib7 914 3 Therapeutic Therapeutic NNP cord-005453-4057qib7 914 4 Medicinal Medicinal NNP cord-005453-4057qib7 914 5 Product Product NNP cord-005453-4057qib7 914 6 is be VBZ cord-005453-4057qib7 914 7 currently currently RB cord-005453-4057qib7 914 8 investigated investigate VBN cord-005453-4057qib7 914 9 in in IN cord-005453-4057qib7 914 10 an an DT cord-005453-4057qib7 914 11 ongoing ongoing JJ cord-005453-4057qib7 914 12 phase phase NN cord-005453-4057qib7 914 13 I I NNP cord-005453-4057qib7 914 14 / / SYM cord-005453-4057qib7 914 15 IIa IIa NNP cord-005453-4057qib7 914 16 trial trial NN cord-005453-4057qib7 914 17 ( ( -LRB- cord-005453-4057qib7 914 18 EudraCT EudraCT NNP cord-005453-4057qib7 914 19 Number number NN cord-005453-4057qib7 914 20 : : : cord-005453-4057qib7 914 21 2012 2012 CD cord-005453-4057qib7 914 22 - - HYPH cord-005453-4057qib7 914 23 004240 004240 CD cord-005453-4057qib7 914 24 - - SYM cord-005453-4057qib7 914 25 30 30 CD cord-005453-4057qib7 914 26 ) ) -RRB- cord-005453-4057qib7 914 27 . . . cord-005453-4057qib7 915 1 However however RB cord-005453-4057qib7 915 2 , , , cord-005453-4057qib7 915 3 the the DT cord-005453-4057qib7 915 4 expansion expansion NN cord-005453-4057qib7 915 5 of of IN cord-005453-4057qib7 915 6 virus virus NN cord-005453-4057qib7 915 7 - - HYPH cord-005453-4057qib7 915 8 specific specific JJ cord-005453-4057qib7 915 9 T t NN cord-005453-4057qib7 915 10 cells cell NNS cord-005453-4057qib7 915 11 relies rely VBZ cord-005453-4057qib7 915 12 on on IN cord-005453-4057qib7 915 13 a a DT cord-005453-4057qib7 915 14 pre pre JJ cord-005453-4057qib7 915 15 - - JJ cord-005453-4057qib7 915 16 existing existing JJ cord-005453-4057qib7 915 17 virusspecific virusspecific NN cord-005453-4057qib7 915 18 memory memory NN cord-005453-4057qib7 915 19 compartment compartment NN cord-005453-4057qib7 915 20 in in IN cord-005453-4057qib7 915 21 the the DT cord-005453-4057qib7 915 22 stem stem NN cord-005453-4057qib7 915 23 cell cell NN cord-005453-4057qib7 915 24 donor donor NN cord-005453-4057qib7 915 25 . . . cord-005453-4057qib7 916 1 In in IN cord-005453-4057qib7 916 2 virus virus NN cord-005453-4057qib7 916 3 - - HYPH cord-005453-4057qib7 916 4 seronegative seronegative JJ cord-005453-4057qib7 916 5 donors donor NNS cord-005453-4057qib7 916 6 , , , cord-005453-4057qib7 916 7 no no DT cord-005453-4057qib7 916 8 expansion expansion NN cord-005453-4057qib7 916 9 can can MD cord-005453-4057qib7 916 10 be be VB cord-005453-4057qib7 916 11 achieved achieve VBN cord-005453-4057qib7 916 12 . . . cord-005453-4057qib7 917 1 We -PRON- PRP cord-005453-4057qib7 917 2 therefore therefore RB cord-005453-4057qib7 917 3 aim aim VBP cord-005453-4057qib7 917 4 to to TO cord-005453-4057qib7 917 5 identify identify VB cord-005453-4057qib7 917 6 EBV EBV NNP cord-005453-4057qib7 917 7 peptide peptide NN cord-005453-4057qib7 917 8 - - HYPH cord-005453-4057qib7 917 9 specific specific JJ cord-005453-4057qib7 917 10 T T NNP cord-005453-4057qib7 917 11 cell cell NN cord-005453-4057qib7 917 12 receptors receptor NNS cord-005453-4057qib7 917 13 ( ( -LRB- cord-005453-4057qib7 917 14 TCRs TCRs NNP cord-005453-4057qib7 917 15 ) ) -RRB- cord-005453-4057qib7 917 16 that that WDT cord-005453-4057qib7 917 17 can can MD cord-005453-4057qib7 917 18 be be VB cord-005453-4057qib7 917 19 translated translate VBN cord-005453-4057qib7 917 20 into into IN cord-005453-4057qib7 917 21 off off IN cord-005453-4057qib7 917 22 - - HYPH cord-005453-4057qib7 917 23 the the DT cord-005453-4057qib7 917 24 - - HYPH cord-005453-4057qib7 917 25 shelf shelf NN cord-005453-4057qib7 917 26 cell cell NN cord-005453-4057qib7 917 27 products product NNS cord-005453-4057qib7 917 28 for for IN cord-005453-4057qib7 917 29 the the DT cord-005453-4057qib7 917 30 treatment treatment NN cord-005453-4057qib7 917 31 and and CC cord-005453-4057qib7 917 32 prophylaxis prophylaxis NN cord-005453-4057qib7 917 33 of of IN cord-005453-4057qib7 917 34 EBV EBV NNP cord-005453-4057qib7 917 35 infection infection NN cord-005453-4057qib7 917 36 and and CC cord-005453-4057qib7 917 37 EBV EBV NNP cord-005453-4057qib7 917 38 - - HYPH cord-005453-4057qib7 917 39 associated associate VBN cord-005453-4057qib7 917 40 malignancies malignancy NNS cord-005453-4057qib7 917 41 . . . cord-005453-4057qib7 918 1 Leftover leftover JJ cord-005453-4057qib7 918 2 cells cell NNS cord-005453-4057qib7 918 3 from from IN cord-005453-4057qib7 918 4 five five CD cord-005453-4057qib7 918 5 allogeneic allogeneic NN cord-005453-4057qib7 918 6 stem stem NN cord-005453-4057qib7 918 7 cell cell NN cord-005453-4057qib7 918 8 grafts graft NNS cord-005453-4057qib7 918 9 were be VBD cord-005453-4057qib7 918 10 expanded expand VBN cord-005453-4057qib7 918 11 in in IN cord-005453-4057qib7 918 12 vitro vitro FW cord-005453-4057qib7 918 13 in in IN cord-005453-4057qib7 918 14 the the DT cord-005453-4057qib7 918 15 presence presence NN cord-005453-4057qib7 918 16 of of IN cord-005453-4057qib7 918 17 HLA HLA NNP cord-005453-4057qib7 918 18 - - HYPH cord-005453-4057qib7 918 19 B35 B35 NNP cord-005453-4057qib7 918 20 * * NFP cord-005453-4057qib7 918 21 01-restricted 01-restricted CD cord-005453-4057qib7 918 22 peptides peptide NNS cord-005453-4057qib7 918 23 ( ( -LRB- cord-005453-4057qib7 918 24 HPVGEADYFEY HPVGEADYFEY NNP cord-005453-4057qib7 918 25 from from IN cord-005453-4057qib7 918 26 EBNA1 EBNA1 NNS cord-005453-4057qib7 918 27 , , , cord-005453-4057qib7 918 28 EPLPQGQL EPLPQGQL NNP cord-005453-4057qib7 918 29 - - HYPH cord-005453-4057qib7 918 30 TAY TAY NNP cord-005453-4057qib7 918 31 from from IN cord-005453-4057qib7 918 32 BZLF1 BZLF1 NNP cord-005453-4057qib7 918 33 ) ) -RRB- cord-005453-4057qib7 918 34 associated associate VBN cord-005453-4057qib7 918 35 with with IN cord-005453-4057qib7 918 36 latent latent JJ cord-005453-4057qib7 918 37 and and CC cord-005453-4057qib7 918 38 lytic lytic JJ cord-005453-4057qib7 918 39 EBV EBV NNP cord-005453-4057qib7 918 40 infection infection NN cord-005453-4057qib7 918 41 . . . cord-005453-4057qib7 919 1 After after IN cord-005453-4057qib7 919 2 expansion expansion NN cord-005453-4057qib7 919 3 , , , cord-005453-4057qib7 919 4 single single JJ cord-005453-4057qib7 919 5 EBV EBV NNP cord-005453-4057qib7 919 6 - - HYPH cord-005453-4057qib7 919 7 specific specific JJ cord-005453-4057qib7 919 8 T t NN cord-005453-4057qib7 919 9 cells cell NNS cord-005453-4057qib7 919 10 were be VBD cord-005453-4057qib7 919 11 FACS FACS NNP cord-005453-4057qib7 919 12 sorted sort VBD cord-005453-4057qib7 919 13 using use VBG cord-005453-4057qib7 919 14 peptide peptide NN cord-005453-4057qib7 919 15 - - HYPH cord-005453-4057qib7 919 16 MHC MHC NNP cord-005453-4057qib7 919 17 ( ( -LRB- cord-005453-4057qib7 919 18 pMHC pmhc NN cord-005453-4057qib7 919 19 ) ) -RRB- cord-005453-4057qib7 919 20 tetramers tetramer NNS cord-005453-4057qib7 919 21 , , , cord-005453-4057qib7 919 22 and and CC cord-005453-4057qib7 919 23 individual individual JJ cord-005453-4057qib7 919 24 TCR TCR NNP cord-005453-4057qib7 919 25 αand αand NN cord-005453-4057qib7 919 26 β β NN cord-005453-4057qib7 919 27 - - HYPH cord-005453-4057qib7 919 28 chain chain NN cord-005453-4057qib7 919 29 pairs pair NNS cord-005453-4057qib7 919 30 were be VBD cord-005453-4057qib7 919 31 determined determine VBN cord-005453-4057qib7 919 32 with with IN cord-005453-4057qib7 919 33 single single JJ cord-005453-4057qib7 919 34 cell cell NN cord-005453-4057qib7 919 35 sequencing sequencing NN cord-005453-4057qib7 919 36 ( ( -LRB- cord-005453-4057qib7 919 37 Han Han NNP cord-005453-4057qib7 919 38 2014 2014 CD cord-005453-4057qib7 919 39 , , , cord-005453-4057qib7 919 40 Penter Penter NNP cord-005453-4057qib7 919 41 2018 2018 CD cord-005453-4057qib7 919 42 . . . cord-005453-4057qib7 920 1 To to TO cord-005453-4057qib7 920 2 confirm confirm VB cord-005453-4057qib7 920 3 peptide peptide JJ cord-005453-4057qib7 920 4 specificity specificity NN cord-005453-4057qib7 920 5 , , , cord-005453-4057qib7 920 6 dominant dominant JJ cord-005453-4057qib7 920 7 TCR TCR NNP cord-005453-4057qib7 920 8 pairs pair NNS cord-005453-4057qib7 920 9 were be VBD cord-005453-4057qib7 920 10 transfected transfecte VBN cord-005453-4057qib7 920 11 into into IN cord-005453-4057qib7 920 12 a a DT cord-005453-4057qib7 920 13 murine murine JJ cord-005453-4057qib7 920 14 58αβreporter 58αβreporter NN cord-005453-4057qib7 920 15 T t NN cord-005453-4057qib7 920 16 hybridoma hybridoma NN cord-005453-4057qib7 920 17 cell cell NN cord-005453-4057qib7 920 18 line line NN cord-005453-4057qib7 920 19 with with IN cord-005453-4057qib7 920 20 NFAT NFAT NNP cord-005453-4057qib7 920 21 - - HYPH cord-005453-4057qib7 920 22 driven drive VBN cord-005453-4057qib7 920 23 GFP GFP NNP cord-005453-4057qib7 920 24 expression expression NN cord-005453-4057qib7 920 25 ( ( -LRB- cord-005453-4057qib7 920 26 Siewert Siewert NNP cord-005453-4057qib7 920 27 , , , cord-005453-4057qib7 920 28 2012 2012 CD cord-005453-4057qib7 920 29 ) ) -RRB- cord-005453-4057qib7 920 30 . . . cord-005453-4057qib7 921 1 Functional Functional NNP cord-005453-4057qib7 921 2 TCRαβ TCRαβ NNP cord-005453-4057qib7 921 3 candidates candidate NNS cord-005453-4057qib7 921 4 were be VBD cord-005453-4057qib7 921 5 transduced transduce VBN cord-005453-4057qib7 921 6 into into IN cord-005453-4057qib7 921 7 human human JJ cord-005453-4057qib7 921 8 peripheral peripheral JJ cord-005453-4057qib7 921 9 Background background NN cord-005453-4057qib7 921 10 : : : cord-005453-4057qib7 922 1 Lymphoid lymphoid JJ cord-005453-4057qib7 922 2 and and CC cord-005453-4057qib7 922 3 myeloid myeloid JJ cord-005453-4057qib7 922 4 acute acute JJ cord-005453-4057qib7 922 5 leukemia leukemia NN cord-005453-4057qib7 922 6 are be VBP cord-005453-4057qib7 922 7 the the DT cord-005453-4057qib7 922 8 most most RBS cord-005453-4057qib7 922 9 frequent frequent JJ cord-005453-4057qib7 922 10 cause cause NN cord-005453-4057qib7 922 11 of of IN cord-005453-4057qib7 922 12 cancer cancer NN cord-005453-4057qib7 922 13 related relate VBN cord-005453-4057qib7 922 14 death death NN cord-005453-4057qib7 922 15 in in IN cord-005453-4057qib7 922 16 children child NNS cord-005453-4057qib7 922 17 . . . cord-005453-4057qib7 923 1 Interactions interaction NNS cord-005453-4057qib7 923 2 between between IN cord-005453-4057qib7 923 3 NKG2D nkg2d NN cord-005453-4057qib7 923 4 receptor receptor NN cord-005453-4057qib7 923 5 , , , cord-005453-4057qib7 923 6 expressed express VBN cord-005453-4057qib7 923 7 in in IN cord-005453-4057qib7 923 8 cytotoxic cytotoxic JJ cord-005453-4057qib7 923 9 immune immune JJ cord-005453-4057qib7 923 10 cells cell NNS cord-005453-4057qib7 923 11 , , , cord-005453-4057qib7 923 12 and and CC cord-005453-4057qib7 923 13 its -PRON- PRP$ cord-005453-4057qib7 923 14 ligands ligand NNS cord-005453-4057qib7 923 15 ( ( -LRB- cord-005453-4057qib7 923 16 NKG2DL NKG2DL NNP cord-005453-4057qib7 923 17 ) ) -RRB- cord-005453-4057qib7 923 18 , , , cord-005453-4057qib7 923 19 that that WDT cord-005453-4057qib7 923 20 are be VBP cord-005453-4057qib7 923 21 upregulated upregulate VBN cord-005453-4057qib7 923 22 in in IN cord-005453-4057qib7 923 23 many many JJ cord-005453-4057qib7 923 24 types type NNS cord-005453-4057qib7 923 25 of of IN cord-005453-4057qib7 923 26 tumor tumor NN cord-005453-4057qib7 923 27 cells cell NNS cord-005453-4057qib7 923 28 including include VBG cord-005453-4057qib7 923 29 leukemic leukemic JJ cord-005453-4057qib7 923 30 blasts blast NNS cord-005453-4057qib7 923 31 , , , cord-005453-4057qib7 923 32 are be VBP cord-005453-4057qib7 923 33 important important JJ cord-005453-4057qib7 923 34 for for IN cord-005453-4057qib7 923 35 anti anti JJ cord-005453-4057qib7 923 36 - - JJ cord-005453-4057qib7 923 37 tumor tumor JJ cord-005453-4057qib7 923 38 immune immune JJ cord-005453-4057qib7 923 39 surveillance surveillance NN cord-005453-4057qib7 923 40 . . . cord-005453-4057qib7 924 1 Nevertheless nevertheless RB cord-005453-4057qib7 924 2 , , , cord-005453-4057qib7 924 3 tumor tumor NN cord-005453-4057qib7 924 4 cells cell NNS cord-005453-4057qib7 924 5 may may MD cord-005453-4057qib7 924 6 develop develop VB cord-005453-4057qib7 924 7 immune immune JJ cord-005453-4057qib7 924 8 scape scape NN cord-005453-4057qib7 924 9 strategies strategy NNS cord-005453-4057qib7 924 10 like like IN cord-005453-4057qib7 924 11 ligand ligand NN cord-005453-4057qib7 924 12 shedding shedding NN cord-005453-4057qib7 924 13 , , , cord-005453-4057qib7 924 14 which which WDT cord-005453-4057qib7 924 15 reduces reduce VBZ cord-005453-4057qib7 924 16 NKG2DL nkg2dl JJ cord-005453-4057qib7 924 17 expression expression NN cord-005453-4057qib7 924 18 and and CC cord-005453-4057qib7 924 19 may may MD cord-005453-4057qib7 924 20 cause cause VB cord-005453-4057qib7 924 21 NKG2D nkg2d JJ cord-005453-4057qib7 924 22 receptor receptor NN cord-005453-4057qib7 924 23 downregulation downregulation NN cord-005453-4057qib7 924 24 . . . cord-005453-4057qib7 925 1 Engineering engineering NN cord-005453-4057qib7 925 2 T t CD cord-005453-4057qib7 925 3 lymphocytes lymphocyte NNS cord-005453-4057qib7 925 4 with with IN cord-005453-4057qib7 925 5 NKG2D nkg2d JJ cord-005453-4057qib7 925 6 CAR car NN cord-005453-4057qib7 925 7 may may MD cord-005453-4057qib7 925 8 overcome overcome VB cord-005453-4057qib7 925 9 immune immune JJ cord-005453-4057qib7 925 10 evasion evasion NN cord-005453-4057qib7 925 11 and and CC cord-005453-4057qib7 925 12 become become VB cord-005453-4057qib7 925 13 an an DT cord-005453-4057qib7 925 14 effective effective JJ cord-005453-4057qib7 925 15 therapeutic therapeutic JJ cord-005453-4057qib7 925 16 strategy strategy NN cord-005453-4057qib7 925 17 . . . cord-005453-4057qib7 926 1 Methods method NNS cord-005453-4057qib7 926 2 : : : cord-005453-4057qib7 926 3 CD45RA cd45ra NN cord-005453-4057qib7 926 4 -T -t NN cord-005453-4057qib7 926 5 cells cell NNS cord-005453-4057qib7 926 6 were be VBD cord-005453-4057qib7 926 7 obtained obtain VBN cord-005453-4057qib7 926 8 by by IN cord-005453-4057qib7 926 9 depletion depletion NN cord-005453-4057qib7 926 10 of of IN cord-005453-4057qib7 926 11 non non JJ cord-005453-4057qib7 926 12 - - JJ cord-005453-4057qib7 926 13 mobilized mobilized JJ cord-005453-4057qib7 926 14 apheresis apheresis NN cord-005453-4057qib7 926 15 with with IN cord-005453-4057qib7 926 16 CD45RA cd45ra NN cord-005453-4057qib7 926 17 magnetic magnetic JJ cord-005453-4057qib7 926 18 beads bead NNS cord-005453-4057qib7 926 19 using use VBG cord-005453-4057qib7 926 20 CliniMACS CliniMACS NNP cord-005453-4057qib7 926 21 . . . cord-005453-4057qib7 927 1 NKG2D nkg2d NN cord-005453-4057qib7 927 2 - - HYPH cord-005453-4057qib7 927 3 CAR car NN cord-005453-4057qib7 927 4 T t NN cord-005453-4057qib7 927 5 cells cell NNS cord-005453-4057qib7 927 6 were be VBD cord-005453-4057qib7 927 7 generated generate VBN cord-005453-4057qib7 927 8 by by IN cord-005453-4057qib7 927 9 lentiviral lentiviral NNP cord-005453-4057qib7 927 10 ( ( -LRB- cord-005453-4057qib7 927 11 NKG2D-41BB NKG2D-41BB NNP cord-005453-4057qib7 927 12 - - HYPH cord-005453-4057qib7 927 13 CD3z CD3z NNP cord-005453-4057qib7 927 14 ) ) -RRB- cord-005453-4057qib7 927 15 transduction transduction NN cord-005453-4057qib7 927 16 of of IN cord-005453-4057qib7 927 17 CD45RA cd45ra NN cord-005453-4057qib7 927 18 -T -T : cord-005453-4057qib7 927 19 cells cell NNS cord-005453-4057qib7 927 20 with with IN cord-005453-4057qib7 927 21 MOI=2 MOI=2 NNP cord-005453-4057qib7 927 22 . . . cord-005453-4057qib7 928 1 The the DT cord-005453-4057qib7 928 2 expression expression NN cord-005453-4057qib7 928 3 of of IN cord-005453-4057qib7 928 4 NKG2D nkg2d NN cord-005453-4057qib7 928 5 ligands ligand NNS cord-005453-4057qib7 928 6 was be VBD cord-005453-4057qib7 928 7 analyzed analyze VBN cord-005453-4057qib7 928 8 in in IN cord-005453-4057qib7 928 9 peripheral peripheral JJ cord-005453-4057qib7 928 10 blood blood NN cord-005453-4057qib7 928 11 or or CC cord-005453-4057qib7 928 12 bone bone NN cord-005453-4057qib7 928 13 marrow marrow NN cord-005453-4057qib7 928 14 samples sample NNS cord-005453-4057qib7 928 15 from from IN cord-005453-4057qib7 928 16 a a DT cord-005453-4057qib7 928 17 total total NN cord-005453-4057qib7 928 18 of of IN cord-005453-4057qib7 928 19 97 97 CD cord-005453-4057qib7 928 20 leukemia leukemia NN cord-005453-4057qib7 928 21 patients patient NNS cord-005453-4057qib7 928 22 ( ( -LRB- cord-005453-4057qib7 928 23 AML=13 AML=13 NNP cord-005453-4057qib7 928 24 , , , cord-005453-4057qib7 928 25 B b NN cord-005453-4057qib7 928 26 - - HYPH cord-005453-4057qib7 928 27 ALL=52 all=52 NN cord-005453-4057qib7 928 28 and and CC cord-005453-4057qib7 928 29 T T NNP cord-005453-4057qib7 928 30 - - HYPH cord-005453-4057qib7 928 31 ALL=19 ALL=19 NNP cord-005453-4057qib7 928 32 ) ) -RRB- cord-005453-4057qib7 928 33 , , , cord-005453-4057qib7 928 34 at at IN cord-005453-4057qib7 928 35 different different JJ cord-005453-4057qib7 928 36 status status NN cord-005453-4057qib7 928 37 of of IN cord-005453-4057qib7 928 38 the the DT cord-005453-4057qib7 928 39 disease disease NN cord-005453-4057qib7 928 40 ( ( -LRB- cord-005453-4057qib7 928 41 Diagnosis diagnosis NN cord-005453-4057qib7 928 42 , , , cord-005453-4057qib7 928 43 Remission remission NN cord-005453-4057qib7 928 44 , , , cord-005453-4057qib7 928 45 Relapse relapse NN cord-005453-4057qib7 928 46 / / SYM cord-005453-4057qib7 928 47 refractory refractory NN cord-005453-4057qib7 928 48 ) ) -RRB- cord-005453-4057qib7 928 49 , , , cord-005453-4057qib7 928 50 and and CC cord-005453-4057qib7 928 51 in in IN cord-005453-4057qib7 928 52 10 10 CD cord-005453-4057qib7 928 53 different different JJ cord-005453-4057qib7 928 54 leukemia leukemia NN cord-005453-4057qib7 928 55 cell cell NN cord-005453-4057qib7 928 56 lines line NNS cord-005453-4057qib7 928 57 by by IN cord-005453-4057qib7 928 58 qPCR qPCR NNP cord-005453-4057qib7 928 59 and and CC cord-005453-4057qib7 928 60 flow flow NN cord-005453-4057qib7 928 61 cytometry cytometry NN cord-005453-4057qib7 928 62 . . . cord-005453-4057qib7 929 1 Cytotoxicity Cytotoxicity NNP cord-005453-4057qib7 929 2 of of IN cord-005453-4057qib7 929 3 NKG2D nkg2d NN cord-005453-4057qib7 929 4 - - HYPH cord-005453-4057qib7 929 5 CAR car NN cord-005453-4057qib7 929 6 T t NN cord-005453-4057qib7 929 7 cells cell NNS cord-005453-4057qib7 929 8 against against IN cord-005453-4057qib7 929 9 leukemia leukemia NN cord-005453-4057qib7 929 10 cells cell NNS cord-005453-4057qib7 929 11 was be VBD cord-005453-4057qib7 929 12 evaluated evaluate VBN cord-005453-4057qib7 929 13 by by IN cord-005453-4057qib7 929 14 performing perform VBG cord-005453-4057qib7 929 15 conventional-4 conventional-4 NNP cord-005453-4057qib7 929 16 hours hour NNS cord-005453-4057qib7 929 17 Europium europium NN cord-005453-4057qib7 929 18 - - HYPH cord-005453-4057qib7 929 19 TDA TDA NNP cord-005453-4057qib7 929 20 assays assay NNS cord-005453-4057qib7 929 21 . . . cord-005453-4057qib7 930 1 Soluble soluble JJ cord-005453-4057qib7 930 2 NKG2DL NKG2DL NNP cord-005453-4057qib7 930 3 ( ( -LRB- cord-005453-4057qib7 930 4 sNKG2DL snkg2dl NN cord-005453-4057qib7 930 5 ) ) -RRB- cord-005453-4057qib7 930 6 concentration concentration NN cord-005453-4057qib7 930 7 was be VBD cord-005453-4057qib7 930 8 measured measure VBN cord-005453-4057qib7 930 9 in in IN cord-005453-4057qib7 930 10 the the DT cord-005453-4057qib7 930 11 sera sera NNP cord-005453-4057qib7 930 12 of of IN cord-005453-4057qib7 930 13 leukemia leukemia NN cord-005453-4057qib7 930 14 patients patient NNS cord-005453-4057qib7 930 15 by by IN cord-005453-4057qib7 930 16 ELISA ELISA NNP cord-005453-4057qib7 930 17 . . . cord-005453-4057qib7 931 1 To to TO cord-005453-4057qib7 931 2 evaluate evaluate VB cord-005453-4057qib7 931 3 the the DT cord-005453-4057qib7 931 4 effect effect NN cord-005453-4057qib7 931 5 of of IN cord-005453-4057qib7 931 6 sNKG2DL snkg2dl NN cord-005453-4057qib7 931 7 on on IN cord-005453-4057qib7 931 8 NKG2D nkg2d CD cord-005453-4057qib7 931 9 - - HYPH cord-005453-4057qib7 931 10 CAR car NN cord-005453-4057qib7 931 11 T t NN cord-005453-4057qib7 931 12 cells cell NNS cord-005453-4057qib7 931 13 , , , cord-005453-4057qib7 931 14 those those DT cord-005453-4057qib7 931 15 were be VBD cord-005453-4057qib7 931 16 cultured culture VBN cord-005453-4057qib7 931 17 in in IN cord-005453-4057qib7 931 18 the the DT cord-005453-4057qib7 931 19 presence presence NN cord-005453-4057qib7 931 20 or or CC cord-005453-4057qib7 931 21 absence absence NN cord-005453-4057qib7 931 22 of of IN cord-005453-4057qib7 931 23 different different JJ cord-005453-4057qib7 931 24 concentrations concentration NNS cord-005453-4057qib7 931 25 of of IN cord-005453-4057qib7 931 26 sNKG2DL snkg2dl NN cord-005453-4057qib7 931 27 for for IN cord-005453-4057qib7 931 28 7 7 CD cord-005453-4057qib7 931 29 days day NNS cord-005453-4057qib7 931 30 . . . cord-005453-4057qib7 932 1 One one CD cord-005453-4057qib7 932 2 week week NN cord-005453-4057qib7 932 3 later later RB cord-005453-4057qib7 932 4 , , , cord-005453-4057qib7 932 5 cell cell NN cord-005453-4057qib7 932 6 proliferation proliferation NN cord-005453-4057qib7 932 7 and and CC cord-005453-4057qib7 932 8 CAR car NN cord-005453-4057qib7 932 9 downregulation downregulation NN cord-005453-4057qib7 932 10 were be VBD cord-005453-4057qib7 932 11 measured measure VBN cord-005453-4057qib7 932 12 by by IN cord-005453-4057qib7 932 13 flow flow NN cord-005453-4057qib7 932 14 cytometry cytometry NN cord-005453-4057qib7 932 15 using use VBG cord-005453-4057qib7 932 16 Cell Cell NNP cord-005453-4057qib7 932 17 Trace Trace NNP cord-005453-4057qib7 932 18 Violet Violet NNP cord-005453-4057qib7 932 19 and and CC cord-005453-4057qib7 932 20 NKG2D nkg2d NN cord-005453-4057qib7 932 21 labeling labeling NN cord-005453-4057qib7 932 22 , , , cord-005453-4057qib7 932 23 respectively respectively RB cord-005453-4057qib7 932 24 . . . cord-005453-4057qib7 933 1 The the DT cord-005453-4057qib7 933 2 production production NN cord-005453-4057qib7 933 3 of of IN cord-005453-4057qib7 933 4 IFN IFN NNP cord-005453-4057qib7 933 5 - - HYPH cord-005453-4057qib7 933 6 g g NNP cord-005453-4057qib7 933 7 and and CC cord-005453-4057qib7 933 8 TNF TNF NNP cord-005453-4057qib7 933 9 - - , cord-005453-4057qib7 933 10 a a NNP cord-005453-4057qib7 933 11 was be VBD cord-005453-4057qib7 933 12 measured measure VBN cord-005453-4057qib7 933 13 in in IN cord-005453-4057qib7 933 14 the the DT cord-005453-4057qib7 933 15 supernatants supernatant NNS cord-005453-4057qib7 933 16 by by IN cord-005453-4057qib7 933 17 ELISA ELISA NNP cord-005453-4057qib7 933 18 . . . cord-005453-4057qib7 934 1 The the DT cord-005453-4057qib7 934 2 effect effect NN cord-005453-4057qib7 934 3 on on IN cord-005453-4057qib7 934 4 cytotoxicity cytotoxicity NN cord-005453-4057qib7 934 5 was be VBD cord-005453-4057qib7 934 6 evaluated evaluate VBN cord-005453-4057qib7 934 7 in in IN cord-005453-4057qib7 934 8 a a DT cord-005453-4057qib7 934 9 2 2 CD cord-005453-4057qib7 934 10 hoursdegranulation hoursdegranulation NN cord-005453-4057qib7 934 11 assay assay NN cord-005453-4057qib7 934 12 by by IN cord-005453-4057qib7 934 13 co co JJ cord-005453-4057qib7 934 14 - - JJ cord-005453-4057qib7 934 15 culturing culture VBG cord-005453-4057qib7 934 16 sNKG2DL snkg2dl NN cord-005453-4057qib7 934 17 pretreated pretreate VBD cord-005453-4057qib7 934 18 NKG2D nkg2d NN cord-005453-4057qib7 934 19 - - HYPH cord-005453-4057qib7 934 20 CAR car NN cord-005453-4057qib7 934 21 T t NN cord-005453-4057qib7 934 22 cells cell NNS cord-005453-4057qib7 934 23 against against IN cord-005453-4057qib7 934 24 K562 k562 CD cord-005453-4057qib7 934 25 cell cell NN cord-005453-4057qib7 934 26 line line NN cord-005453-4057qib7 934 27 . . . cord-005453-4057qib7 935 1 Results result NNS cord-005453-4057qib7 935 2 : : : cord-005453-4057qib7 936 1 NKG2D nkg2d NN cord-005453-4057qib7 936 2 ligands ligand NNS cord-005453-4057qib7 936 3 were be VBD cord-005453-4057qib7 936 4 expressed express VBN cord-005453-4057qib7 936 5 in in IN cord-005453-4057qib7 936 6 leukemia leukemia NN cord-005453-4057qib7 936 7 cell cell NN cord-005453-4057qib7 936 8 lines line NNS cord-005453-4057qib7 936 9 and and CC cord-005453-4057qib7 936 10 leukemic leukemic JJ cord-005453-4057qib7 936 11 blasts blast NNS cord-005453-4057qib7 936 12 . . . cord-005453-4057qib7 937 1 NKG2DL nkg2dl JJ cord-005453-4057qib7 937 2 expression expression NN cord-005453-4057qib7 937 3 changed change VBD cord-005453-4057qib7 937 4 with with IN cord-005453-4057qib7 937 5 disease disease NN cord-005453-4057qib7 937 6 status status NN cord-005453-4057qib7 937 7 with with IN cord-005453-4057qib7 937 8 a a DT cord-005453-4057qib7 937 9 trend trend NN cord-005453-4057qib7 937 10 to to TO cord-005453-4057qib7 937 11 decrease decrease VB cord-005453-4057qib7 937 12 at at IN cord-005453-4057qib7 937 13 diagnosis diagnosis NN cord-005453-4057qib7 937 14 and and CC cord-005453-4057qib7 937 15 relapse relapse NN cord-005453-4057qib7 937 16 / / SYM cord-005453-4057qib7 937 17 refractory refractory NN cord-005453-4057qib7 937 18 compared compare VBN cord-005453-4057qib7 937 19 to to IN cord-005453-4057qib7 937 20 remission remission NN cord-005453-4057qib7 937 21 . . . cord-005453-4057qib7 938 1 NKG2D nkg2d NN cord-005453-4057qib7 938 2 - - HYPH cord-005453-4057qib7 938 3 CAR car NN cord-005453-4057qib7 938 4 T t NN cord-005453-4057qib7 938 5 cells cell NNS cord-005453-4057qib7 938 6 were be VBD cord-005453-4057qib7 938 7 cytotoxic cytotoxic JJ cord-005453-4057qib7 938 8 against against IN cord-005453-4057qib7 938 9 8/10 8/10 CD cord-005453-4057qib7 938 10 leukemia leukemia NN cord-005453-4057qib7 938 11 cell cell NN cord-005453-4057qib7 938 12 lines line NNS cord-005453-4057qib7 938 13 with with IN cord-005453-4057qib7 938 14 a a DT cord-005453-4057qib7 938 15 percentage percentage NN cord-005453-4057qib7 938 16 of of IN cord-005453-4057qib7 938 17 specific specific JJ cord-005453-4057qib7 938 18 lysis lysis NN cord-005453-4057qib7 938 19 over over IN cord-005453-4057qib7 938 20 50 50 CD cord-005453-4057qib7 938 21 % % NN cord-005453-4057qib7 938 22 . . . cord-005453-4057qib7 939 1 Myeloid Myeloid NNP cord-005453-4057qib7 939 2 and and CC cord-005453-4057qib7 939 3 T t NN cord-005453-4057qib7 939 4 - - HYPH cord-005453-4057qib7 939 5 ALL all DT cord-005453-4057qib7 939 6 cell cell NN cord-005453-4057qib7 939 7 lines line NNS cord-005453-4057qib7 939 8 were be VBD cord-005453-4057qib7 939 9 more more RBR cord-005453-4057qib7 939 10 susceptible susceptible JJ cord-005453-4057qib7 939 11 to to IN cord-005453-4057qib7 939 12 NKG2D nkg2d NN cord-005453-4057qib7 939 13 - - HYPH cord-005453-4057qib7 939 14 CAR car NN cord-005453-4057qib7 939 15 T t NN cord-005453-4057qib7 939 16 cells cell NNS cord-005453-4057qib7 939 17 ( ( -LRB- cord-005453-4057qib7 939 18 specific specific JJ cord-005453-4057qib7 939 19 lysis lysis NN cord-005453-4057qib7 939 20 ranging range VBG cord-005453-4057qib7 939 21 from from IN cord-005453-4057qib7 939 22 50 50 CD cord-005453-4057qib7 939 23 - - SYM cord-005453-4057qib7 939 24 78 78 CD cord-005453-4057qib7 939 25 % % NN cord-005453-4057qib7 939 26 ) ) -RRB- cord-005453-4057qib7 939 27 compared compare VBN cord-005453-4057qib7 939 28 to to IN cord-005453-4057qib7 939 29 B b NN cord-005453-4057qib7 939 30 - - : cord-005453-4057qib7 939 31 ALL all DT cord-005453-4057qib7 939 32 cell cell NN cord-005453-4057qib7 939 33 lines line NNS cord-005453-4057qib7 939 34 ( ( -LRB- cord-005453-4057qib7 939 35 19 19 CD cord-005453-4057qib7 939 36 - - SYM cord-005453-4057qib7 939 37 52 52 CD cord-005453-4057qib7 939 38 % % NN cord-005453-4057qib7 939 39 ) ) -RRB- cord-005453-4057qib7 939 40 . . . cord-005453-4057qib7 940 1 Physiological physiological JJ cord-005453-4057qib7 940 2 concentrations concentration NNS cord-005453-4057qib7 940 3 of of IN cord-005453-4057qib7 940 4 sNKG2DL snkg2dl NN cord-005453-4057qib7 940 5 caused cause VBD cord-005453-4057qib7 940 6 an an DT cord-005453-4057qib7 940 7 increase increase NN cord-005453-4057qib7 940 8 in in IN cord-005453-4057qib7 940 9 NKG2D nkg2d CD cord-005453-4057qib7 940 10 - - HYPH cord-005453-4057qib7 940 11 CAR car NN cord-005453-4057qib7 940 12 expression expression NN cord-005453-4057qib7 940 13 . . . cord-005453-4057qib7 941 1 However however RB cord-005453-4057qib7 941 2 , , , cord-005453-4057qib7 941 3 supra supra JJ cord-005453-4057qib7 941 4 - - HYPH cord-005453-4057qib7 941 5 physiological physiological JJ cord-005453-4057qib7 941 6 levels level NNS cord-005453-4057qib7 941 7 of of IN cord-005453-4057qib7 941 8 sNKG2DL snkg2dl NN cord-005453-4057qib7 941 9 decreased decrease VBD cord-005453-4057qib7 941 10 NKG2D nkg2d JJ cord-005453-4057qib7 941 11 - - HYPH cord-005453-4057qib7 941 12 CAR car NN cord-005453-4057qib7 941 13 expression expression NN cord-005453-4057qib7 941 14 up up IN cord-005453-4057qib7 941 15 to to TO cord-005453-4057qib7 941 16 5 5 CD cord-005453-4057qib7 941 17 times time NNS cord-005453-4057qib7 941 18 and and CC cord-005453-4057qib7 941 19 increased increased JJ cord-005453-4057qib7 941 20 cell cell NN cord-005453-4057qib7 941 21 proliferation proliferation NN cord-005453-4057qib7 941 22 up up IN cord-005453-4057qib7 941 23 to to IN cord-005453-4057qib7 941 24 4 4 CD cord-005453-4057qib7 941 25 times time NNS cord-005453-4057qib7 941 26 . . . cord-005453-4057qib7 942 1 CD4 CD4 NNP cord-005453-4057qib7 942 2 + + CC cord-005453-4057qib7 942 3 subpopulation subpopulation NN cord-005453-4057qib7 942 4 was be VBD cord-005453-4057qib7 942 5 more more RBR cord-005453-4057qib7 942 6 affected affect VBN cord-005453-4057qib7 942 7 by by IN cord-005453-4057qib7 942 8 downregulation downregulation NN cord-005453-4057qib7 942 9 , , , cord-005453-4057qib7 942 10 while while IN cord-005453-4057qib7 942 11 proliferation proliferation NN cord-005453-4057qib7 942 12 had have VBD cord-005453-4057qib7 942 13 more more JJR cord-005453-4057qib7 942 14 impact impact NN cord-005453-4057qib7 942 15 on on IN cord-005453-4057qib7 942 16 CD8 CD8 NNP cord-005453-4057qib7 942 17 + + CC cord-005453-4057qib7 942 18 subset subset NNP cord-005453-4057qib7 942 19 . . . cord-005453-4057qib7 943 1 The the DT cord-005453-4057qib7 943 2 effects effect NNS cord-005453-4057qib7 943 3 of of IN cord-005453-4057qib7 943 4 sNKG2DL snkg2dl NN cord-005453-4057qib7 943 5 were be VBD cord-005453-4057qib7 943 6 dose dose NN cord-005453-4057qib7 943 7 - - HYPH cord-005453-4057qib7 943 8 dependent dependent JJ cord-005453-4057qib7 943 9 and and CC cord-005453-4057qib7 943 10 attenuated attenuate VBN cord-005453-4057qib7 943 11 by by IN cord-005453-4057qib7 943 12 IL-2 IL-2 NNP cord-005453-4057qib7 943 13 . . . cord-005453-4057qib7 943 14 Conclusions conclusion NNS cord-005453-4057qib7 943 15 : : : cord-005453-4057qib7 944 1 NKG2D nkg2d NN cord-005453-4057qib7 944 2 - - HYPH cord-005453-4057qib7 944 3 CAR car NN cord-005453-4057qib7 944 4 T t NN cord-005453-4057qib7 944 5 cells cell NNS cord-005453-4057qib7 944 6 are be VBP cord-005453-4057qib7 944 7 cytotoxic cytotoxic JJ cord-005453-4057qib7 944 8 against against IN cord-005453-4057qib7 944 9 leukemia leukemia NN cord-005453-4057qib7 944 10 cells cell NNS cord-005453-4057qib7 944 11 , , , cord-005453-4057qib7 944 12 specially specially RB cord-005453-4057qib7 944 13 AML AML NNP cord-005453-4057qib7 944 14 and and CC cord-005453-4057qib7 944 15 T T NNP cord-005453-4057qib7 944 16 - - HYPH cord-005453-4057qib7 944 17 ALL ALL NNP cord-005453-4057qib7 944 18 , , , cord-005453-4057qib7 944 19 and and CC cord-005453-4057qib7 944 20 thus thus RB cord-005453-4057qib7 944 21 could could MD cord-005453-4057qib7 944 22 be be VB cord-005453-4057qib7 944 23 a a DT cord-005453-4057qib7 944 24 novel novel JJ cord-005453-4057qib7 944 25 therapeutic therapeutic JJ cord-005453-4057qib7 944 26 approach approach NN cord-005453-4057qib7 944 27 for for IN cord-005453-4057qib7 944 28 non non JJ cord-005453-4057qib7 944 29 - - JJ cord-005453-4057qib7 944 30 B b JJ cord-005453-4057qib7 944 31 leukemia leukemia NN cord-005453-4057qib7 944 32 , , , cord-005453-4057qib7 944 33 or or CC cord-005453-4057qib7 944 34 those those DT cord-005453-4057qib7 944 35 B b NN cord-005453-4057qib7 944 36 - - , cord-005453-4057qib7 944 37 ALL all PDT cord-005453-4057qib7 944 38 that that DT cord-005453-4057qib7 944 39 relapse relapse VBP cord-005453-4057qib7 944 40 with with IN cord-005453-4057qib7 944 41 undetectable undetectable JJ cord-005453-4057qib7 944 42 CD19 CD19 NNP cord-005453-4057qib7 944 43 after after IN cord-005453-4057qib7 944 44 CD19-CAR cd19-car JJ cord-005453-4057qib7 944 45 treatment treatment NN cord-005453-4057qib7 944 46 . . . cord-005453-4057qib7 945 1 NKG2D nkg2d JJ cord-005453-4057qib7 945 2 - - HYPH cord-005453-4057qib7 945 3 CAR car NN cord-005453-4057qib7 945 4 expression expression NN cord-005453-4057qib7 945 5 may may MD cord-005453-4057qib7 945 6 be be VB cord-005453-4057qib7 945 7 downregulated downregulate VBN cord-005453-4057qib7 945 8 only only RB cord-005453-4057qib7 945 9 by by IN cord-005453-4057qib7 945 10 supra supra JJ cord-005453-4057qib7 945 11 - - HYPH cord-005453-4057qib7 945 12 physiological physiological JJ cord-005453-4057qib7 945 13 levels level NNS cord-005453-4057qib7 945 14 of of IN cord-005453-4057qib7 945 15 sNKG2DL snkg2dl NN cord-005453-4057qib7 945 16 , , , cord-005453-4057qib7 945 17 although although IN cord-005453-4057qib7 945 18 antitumor antitumor JJ cord-005453-4057qib7 945 19 activity activity NN cord-005453-4057qib7 945 20 is be VBZ cord-005453-4057qib7 945 21 not not RB cord-005453-4057qib7 945 22 affected affect VBN cord-005453-4057qib7 945 23 . . . cord-005453-4057qib7 946 1 IL-2 IL-2 NNP cord-005453-4057qib7 946 2 softens soften VBZ cord-005453-4057qib7 946 3 the the DT cord-005453-4057qib7 946 4 negative negative JJ cord-005453-4057qib7 946 5 effects effect NNS cord-005453-4057qib7 946 6 of of IN cord-005453-4057qib7 946 7 sNKG2DL snkg2dl JJ cord-005453-4057qib7 946 8 inducing induce VBG cord-005453-4057qib7 946 9 NKG2D nkg2d JJ cord-005453-4057qib7 946 10 expression expression NN cord-005453-4057qib7 946 11 , , , cord-005453-4057qib7 946 12 cell cell NN cord-005453-4057qib7 946 13 proliferation proliferation NN cord-005453-4057qib7 946 14 and and CC cord-005453-4057qib7 946 15 cytokines cytokine NNS cord-005453-4057qib7 946 16 production production NN cord-005453-4057qib7 946 17 . . . cord-005453-4057qib7 947 1 The the DT cord-005453-4057qib7 947 2 changes change NNS cord-005453-4057qib7 947 3 observed observe VBN cord-005453-4057qib7 947 4 in in IN cord-005453-4057qib7 947 5 NKG2DL NKG2DL NNP cord-005453-4057qib7 947 6 surface surface NN cord-005453-4057qib7 947 7 expression expression NN cord-005453-4057qib7 947 8 at at IN cord-005453-4057qib7 947 9 the the DT cord-005453-4057qib7 947 10 different different JJ cord-005453-4057qib7 947 11 stages stage NNS cord-005453-4057qib7 947 12 of of IN cord-005453-4057qib7 947 13 the the DT cord-005453-4057qib7 947 14 disease disease NN cord-005453-4057qib7 947 15 could could MD cord-005453-4057qib7 947 16 be be VB cord-005453-4057qib7 947 17 related relate VBN cord-005453-4057qib7 947 18 to to IN cord-005453-4057qib7 947 19 ligands ligand NNS cord-005453-4057qib7 947 20 release release NN cord-005453-4057qib7 947 21 and and CC cord-005453-4057qib7 947 22 immune immune JJ cord-005453-4057qib7 947 23 escape escape NN cord-005453-4057qib7 947 24 . . . cord-005453-4057qib7 948 1 Disclosure disclosure NN cord-005453-4057qib7 948 2 : : : cord-005453-4057qib7 948 3 Nothing nothing NN cord-005453-4057qib7 948 4 to to TO cord-005453-4057qib7 948 5 declare declare VB cord-005453-4057qib7 948 6 Denis Denis NNP cord-005453-4057qib7 948 7 - - HYPH cord-005453-4057qib7 948 8 Claude Claude NNP cord-005453-4057qib7 948 9 Roy Roy NNP cord-005453-4057qib7 948 10 1,2 1,2 CD cord-005453-4057qib7 948 11 , , , cord-005453-4057qib7 948 12 Ines Ines NNP cord-005453-4057qib7 948 13 Adassi Adassi NNP cord-005453-4057qib7 948 14 1,2 1,2 CD cord-005453-4057qib7 948 15 , , , cord-005453-4057qib7 948 16 Céline Céline NNP cord-005453-4057qib7 948 17 Leboeuf Leboeuf NNP cord-005453-4057qib7 948 18 1,2 1,2 CD cord-005453-4057qib7 948 19 , , , cord-005453-4057qib7 948 20 Vibhuti Vibhuti NNP cord-005453-4057qib7 948 21 P. P. NNP cord-005453-4057qib7 948 22 Dave Dave NNP cord-005453-4057qib7 948 23 1,2 1,2 CD cord-005453-4057qib7 948 24 1 1 CD cord-005453-4057qib7 948 25 Hôpital Hôpital NNP cord-005453-4057qib7 948 26 Maisonneuve Maisonneuve NNP cord-005453-4057qib7 948 27 - - HYPH cord-005453-4057qib7 948 28 Rosemont Rosemont NNP cord-005453-4057qib7 948 29 Research Research NNP cord-005453-4057qib7 948 30 Center Center NNP cord-005453-4057qib7 948 31 , , , cord-005453-4057qib7 948 32 Montréal Montréal NNP cord-005453-4057qib7 948 33 , , , cord-005453-4057qib7 948 34 Canada Canada NNP cord-005453-4057qib7 948 35 , , , cord-005453-4057qib7 948 36 2 2 CD cord-005453-4057qib7 948 37 University University NNP cord-005453-4057qib7 948 38 of of IN cord-005453-4057qib7 948 39 Montréal Montréal NNP cord-005453-4057qib7 948 40 , , , cord-005453-4057qib7 948 41 Montréal Montréal NNP cord-005453-4057qib7 948 42 , , , cord-005453-4057qib7 948 43 Canada Canada NNP cord-005453-4057qib7 948 44 Background Background NNP cord-005453-4057qib7 948 45 : : : cord-005453-4057qib7 949 1 For for IN cord-005453-4057qib7 949 2 patients patient NNS cord-005453-4057qib7 949 3 with with IN cord-005453-4057qib7 949 4 high high JJ cord-005453-4057qib7 949 5 - - HYPH cord-005453-4057qib7 949 6 risk risk NN cord-005453-4057qib7 949 7 leukaemia leukaemia NN cord-005453-4057qib7 949 8 , , , cord-005453-4057qib7 949 9 allogeneic allogeneic IN cord-005453-4057qib7 949 10 haematopoietic haematopoietic JJ cord-005453-4057qib7 949 11 stem stem NN cord-005453-4057qib7 949 12 cell cell NN cord-005453-4057qib7 949 13 transplantation transplantation NN cord-005453-4057qib7 949 14 is be VBZ cord-005453-4057qib7 949 15 the the DT cord-005453-4057qib7 949 16 only only JJ cord-005453-4057qib7 949 17 curative curative JJ cord-005453-4057qib7 949 18 treatment treatment NN cord-005453-4057qib7 949 19 . . . cord-005453-4057qib7 950 1 The the DT cord-005453-4057qib7 950 2 presence presence NN cord-005453-4057qib7 950 3 of of IN cord-005453-4057qib7 950 4 alloreactive alloreactive NNP cord-005453-4057qib7 950 5 T T NNP cord-005453-4057qib7 950 6 cells cell NNS cord-005453-4057qib7 950 7 in in IN cord-005453-4057qib7 950 8 the the DT cord-005453-4057qib7 950 9 donor donor NN cord-005453-4057qib7 950 10 graft graft NN cord-005453-4057qib7 950 11 , , , cord-005453-4057qib7 950 12 however however RB cord-005453-4057qib7 950 13 , , , cord-005453-4057qib7 950 14 leads lead VBZ cord-005453-4057qib7 950 15 to to IN cord-005453-4057qib7 950 16 a a DT cord-005453-4057qib7 950 17 high high JJ cord-005453-4057qib7 950 18 probability probability NN cord-005453-4057qib7 950 19 of of IN cord-005453-4057qib7 950 20 developing develop VBG cord-005453-4057qib7 950 21 graft graft NN cord-005453-4057qib7 950 22 - - HYPH cord-005453-4057qib7 950 23 versus versus IN cord-005453-4057qib7 950 24 - - HYPH cord-005453-4057qib7 950 25 host host NN cord-005453-4057qib7 950 26 disease disease NN cord-005453-4057qib7 950 27 ( ( -LRB- cord-005453-4057qib7 950 28 GVHD GVHD NNP cord-005453-4057qib7 950 29 ) ) -RRB- cord-005453-4057qib7 950 30 . . . cord-005453-4057qib7 951 1 T t NN cord-005453-4057qib7 951 2 - - HYPH cord-005453-4057qib7 951 3 cell cell NN cord-005453-4057qib7 951 4 depletion depletion NN cord-005453-4057qib7 951 5 minimises minimise VBZ cord-005453-4057qib7 951 6 the the DT cord-005453-4057qib7 951 7 presence presence NN cord-005453-4057qib7 951 8 of of IN cord-005453-4057qib7 951 9 GVHD GVHD NNP cord-005453-4057qib7 951 10 - - HYPH cord-005453-4057qib7 951 11 causing cause VBG cord-005453-4057qib7 951 12 alloreactive alloreactive JJ cord-005453-4057qib7 951 13 cells cell NNS cord-005453-4057qib7 951 14 , , , cord-005453-4057qib7 951 15 but but CC cord-005453-4057qib7 951 16 often often RB cord-005453-4057qib7 951 17 results result VBZ cord-005453-4057qib7 951 18 in in IN cord-005453-4057qib7 951 19 an an DT cord-005453-4057qib7 951 20 increased increase VBN cord-005453-4057qib7 951 21 incidence incidence NN cord-005453-4057qib7 951 22 of of IN cord-005453-4057qib7 951 23 infections infection NNS cord-005453-4057qib7 951 24 and and CC cord-005453-4057qib7 951 25 disease disease NN cord-005453-4057qib7 951 26 relapse relapse NN cord-005453-4057qib7 951 27 . . . cord-005453-4057qib7 952 1 Photodepletion photodepletion NN cord-005453-4057qib7 952 2 treatment treatment NN cord-005453-4057qib7 952 3 ( ( -LRB- cord-005453-4057qib7 952 4 PDT PDT NNP cord-005453-4057qib7 952 5 ) ) -RRB- cord-005453-4057qib7 952 6 can can MD cord-005453-4057qib7 952 7 specifically specifically RB cord-005453-4057qib7 952 8 deplete deplete VB cord-005453-4057qib7 952 9 activated activate VBN cord-005453-4057qib7 952 10 alloreactive alloreactive NNP cord-005453-4057qib7 952 11 T t NN cord-005453-4057qib7 952 12 cells cell NNS cord-005453-4057qib7 952 13 while while IN cord-005453-4057qib7 952 14 conserving conserve VBG cord-005453-4057qib7 952 15 resting rest VBG cord-005453-4057qib7 952 16 T T NNP cord-005453-4057qib7 952 17 cells cell NNS cord-005453-4057qib7 952 18 . . . cord-005453-4057qib7 953 1 PDT PDT NNP cord-005453-4057qib7 953 2 - - HYPH cord-005453-4057qib7 953 3 treated treat VBN cord-005453-4057qib7 953 4 cells cell NNS cord-005453-4057qib7 953 5 have have VBP cord-005453-4057qib7 953 6 been be VBN cord-005453-4057qib7 953 7 utilised utilise VBN cord-005453-4057qib7 953 8 after after IN cord-005453-4057qib7 953 9 T t NN cord-005453-4057qib7 953 10 - - HYPH cord-005453-4057qib7 953 11 cell cell NN cord-005453-4057qib7 953 12 - - HYPH cord-005453-4057qib7 953 13 depleted deplete VBN cord-005453-4057qib7 953 14 haploidentical haploidentical JJ cord-005453-4057qib7 953 15 transplant transplant NN cord-005453-4057qib7 953 16 to to TO cord-005453-4057qib7 953 17 help help VB cord-005453-4057qib7 953 18 reduce reduce VB cord-005453-4057qib7 953 19 infection infection NN cord-005453-4057qib7 953 20 and and CC cord-005453-4057qib7 953 21 relapse relapse NN cord-005453-4057qib7 953 22 . . . cord-005453-4057qib7 954 1 The the DT cord-005453-4057qib7 954 2 efficacy efficacy NN cord-005453-4057qib7 954 3 and and CC cord-005453-4057qib7 954 4 safety safety NN cord-005453-4057qib7 954 5 of of IN cord-005453-4057qib7 954 6 such such JJ cord-005453-4057qib7 954 7 PDT PDT NNP cord-005453-4057qib7 954 8 - - HYPH cord-005453-4057qib7 954 9 treated treat VBN cord-005453-4057qib7 954 10 cells cell NNS cord-005453-4057qib7 954 11 is be VBZ cord-005453-4057qib7 954 12 currently currently RB cord-005453-4057qib7 954 13 under under IN cord-005453-4057qib7 954 14 clinical clinical JJ cord-005453-4057qib7 954 15 investigation investigation NN cord-005453-4057qib7 954 16 in in IN cord-005453-4057qib7 954 17 a a DT cord-005453-4057qib7 954 18 phase phase NN cord-005453-4057qib7 954 19 III iii CD cord-005453-4057qib7 954 20 trial trial NN cord-005453-4057qib7 954 21 ( ( -LRB- cord-005453-4057qib7 954 22 HATCY HATCY NNP cord-005453-4057qib7 954 23 , , , cord-005453-4057qib7 954 24 NCT02999854 NCT02999854 NNP cord-005453-4057qib7 954 25 ; ; : cord-005453-4057qib7 954 26 Kiadis Kiadis NNP cord-005453-4057qib7 954 27 Pharma Pharma NNP cord-005453-4057qib7 954 28 ) ) -RRB- cord-005453-4057qib7 954 29 . . . cord-005453-4057qib7 955 1 Here here RB cord-005453-4057qib7 955 2 the the DT cord-005453-4057qib7 955 3 reactivity reactivity NN cord-005453-4057qib7 955 4 of of IN cord-005453-4057qib7 955 5 PDT PDT NNP cord-005453-4057qib7 955 6 - - HYPH cord-005453-4057qib7 955 7 treated treat VBN cord-005453-4057qib7 955 8 donor donor NN cord-005453-4057qib7 955 9 T t NN cord-005453-4057qib7 955 10 cells cell NNS cord-005453-4057qib7 955 11 was be VBD cord-005453-4057qib7 955 12 assessed assess VBN cord-005453-4057qib7 955 13 toward toward IN cord-005453-4057qib7 955 14 tumour tumour NN cord-005453-4057qib7 955 15 - - HYPH cord-005453-4057qib7 955 16 associated associate VBN cord-005453-4057qib7 955 17 and and CC cord-005453-4057qib7 955 18 viral viral JJ cord-005453-4057qib7 955 19 antigenic antigenic JJ cord-005453-4057qib7 955 20 peptides peptide NNS cord-005453-4057qib7 955 21 derived derive VBN cord-005453-4057qib7 955 22 from from IN cord-005453-4057qib7 955 23 Wilm Wilm NNP cord-005453-4057qib7 955 24 's 's POS cord-005453-4057qib7 955 25 Tumour tumour NN cord-005453-4057qib7 955 26 protein protein NN cord-005453-4057qib7 955 27 1 1 CD cord-005453-4057qib7 955 28 ( ( -LRB- cord-005453-4057qib7 955 29 WT1p WT1p NNP cord-005453-4057qib7 955 30 ) ) -RRB- cord-005453-4057qib7 955 31 , , , cord-005453-4057qib7 955 32 preferentially preferentially RB cord-005453-4057qib7 955 33 expressed express VBD cord-005453-4057qib7 955 34 antigen antigen NN cord-005453-4057qib7 955 35 in in IN cord-005453-4057qib7 955 36 melanoma melanoma NN cord-005453-4057qib7 955 37 ( ( -LRB- cord-005453-4057qib7 955 38 PRAMEp PRAMEp NNS cord-005453-4057qib7 955 39 ) ) -RRB- cord-005453-4057qib7 955 40 , , , cord-005453-4057qib7 955 41 and and CC cord-005453-4057qib7 955 42 from from IN cord-005453-4057qib7 955 43 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 955 44 and and CC cord-005453-4057qib7 955 45 Epstein Epstein NNP cord-005453-4057qib7 955 46 - - HYPH cord-005453-4057qib7 955 47 Barr Barr NNP cord-005453-4057qib7 955 48 virus virus NN cord-005453-4057qib7 955 49 ( ( -LRB- cord-005453-4057qib7 955 50 CMV/ CMV/ NNP cord-005453-4057qib7 955 51 EBVp EBVp NNPS cord-005453-4057qib7 955 52 ) ) -RRB- cord-005453-4057qib7 955 53 . . . cord-005453-4057qib7 956 1 Methods method NNS cord-005453-4057qib7 956 2 : : : cord-005453-4057qib7 956 3 Healthy healthy JJ cord-005453-4057qib7 956 4 donor donor NN cord-005453-4057qib7 956 5 ( ( -LRB- cord-005453-4057qib7 956 6 HLA HLA NNP cord-005453-4057qib7 956 7 - - HYPH cord-005453-4057qib7 956 8 A*0201 A*0201 NNP cord-005453-4057qib7 956 9 ) ) -RRB- cord-005453-4057qib7 956 10 peripheral peripheral JJ cord-005453-4057qib7 956 11 blood blood NN cord-005453-4057qib7 956 12 mononuclear mononuclear NN cord-005453-4057qib7 956 13 cells cell NNS cord-005453-4057qib7 956 14 ( ( -LRB- cord-005453-4057qib7 956 15 PBMCs pbmc NNS cord-005453-4057qib7 956 16 ) ) -RRB- cord-005453-4057qib7 956 17 were be VBD cord-005453-4057qib7 956 18 co co JJ cord-005453-4057qib7 956 19 - - JJ cord-005453-4057qib7 956 20 cultured cultured JJ cord-005453-4057qib7 956 21 with with IN cord-005453-4057qib7 956 22 irradiated irradiated JJ cord-005453-4057qib7 956 23 PBMCs pbmc NNS cord-005453-4057qib7 956 24 from from IN cord-005453-4057qib7 956 25 another another DT cord-005453-4057qib7 956 26 mismatched mismatched JJ cord-005453-4057qib7 956 27 donor donor NN cord-005453-4057qib7 956 28 ( ( -LRB- cord-005453-4057qib7 956 29 1:1 1:1 LS cord-005453-4057qib7 956 30 ) ) -RRB- cord-005453-4057qib7 956 31 in in IN cord-005453-4057qib7 956 32 a a DT cord-005453-4057qib7 956 33 4-day 4-day JJ cord-005453-4057qib7 956 34 mixed mixed JJ cord-005453-4057qib7 956 35 lymphocyte lymphocyte NN cord-005453-4057qib7 956 36 reaction reaction NN cord-005453-4057qib7 956 37 . . . cord-005453-4057qib7 957 1 TH9402 TH9402 NNP cord-005453-4057qib7 957 2 , , , cord-005453-4057qib7 957 3 a a DT cord-005453-4057qib7 957 4 photoactive photoactive JJ cord-005453-4057qib7 957 5 rhodamine rhodamine NN cord-005453-4057qib7 957 6 derivative derivative JJ cord-005453-4057qib7 957 7 , , , cord-005453-4057qib7 957 8 was be VBD cord-005453-4057qib7 957 9 added add VBN cord-005453-4057qib7 957 10 and and CC cord-005453-4057qib7 957 11 cells cell NNS cord-005453-4057qib7 957 12 were be VBD cord-005453-4057qib7 957 13 exposed expose VBN cord-005453-4057qib7 957 14 to to IN cord-005453-4057qib7 957 15 visible visible JJ cord-005453-4057qib7 957 16 light light NN cord-005453-4057qib7 957 17 to to TO cord-005453-4057qib7 957 18 deplete deplete VB cord-005453-4057qib7 957 19 the the DT cord-005453-4057qib7 957 20 TH9402-containing TH9402-containing NNP cord-005453-4057qib7 957 21 activated activate VBN cord-005453-4057qib7 957 22 alloreactive alloreactive JJ cord-005453-4057qib7 957 23 cells cell NNS cord-005453-4057qib7 957 24 . . . cord-005453-4057qib7 958 1 Elimination elimination NN cord-005453-4057qib7 958 2 of of IN cord-005453-4057qib7 958 3 alloreactive alloreactive JJ cord-005453-4057qib7 958 4 cells cell NNS cord-005453-4057qib7 958 5 post post VBP cord-005453-4057qib7 958 6 - - NNP cord-005453-4057qib7 958 7 PDT PDT NNP cord-005453-4057qib7 958 8 was be VBD cord-005453-4057qib7 958 9 assessed assess VBN cord-005453-4057qib7 958 10 using use VBG cord-005453-4057qib7 958 11 CD25 CD25 NNP cord-005453-4057qib7 958 12 and and CC cord-005453-4057qib7 958 13 HLA HLA NNP cord-005453-4057qib7 958 14 - - HYPH cord-005453-4057qib7 958 15 DR DR NNP cord-005453-4057qib7 958 16 as as IN cord-005453-4057qib7 958 17 activation activation NN cord-005453-4057qib7 958 18 markers marker NNS cord-005453-4057qib7 958 19 . . . cord-005453-4057qib7 959 1 An an DT cord-005453-4057qib7 959 2 ex ex FW cord-005453-4057qib7 959 3 vivo vivo NN cord-005453-4057qib7 959 4 expansion expansion NN cord-005453-4057qib7 959 5 protocol protocol NN cord-005453-4057qib7 959 6 was be VBD cord-005453-4057qib7 959 7 exploited exploit VBN cord-005453-4057qib7 959 8 to to TO cord-005453-4057qib7 959 9 evaluate evaluate VB cord-005453-4057qib7 959 10 the the DT cord-005453-4057qib7 959 11 impact impact NN cord-005453-4057qib7 959 12 of of IN cord-005453-4057qib7 959 13 PDT PDT NNP cord-005453-4057qib7 959 14 on on IN cord-005453-4057qib7 959 15 reactivity reactivity NN cord-005453-4057qib7 959 16 to to IN cord-005453-4057qib7 959 17 tumour tumour NN cord-005453-4057qib7 959 18 and and CC cord-005453-4057qib7 959 19 viral viral JJ cord-005453-4057qib7 959 20 antigenic antigenic JJ cord-005453-4057qib7 959 21 peptides peptide NNS cord-005453-4057qib7 959 22 . . . cord-005453-4057qib7 960 1 Post Post NNP cord-005453-4057qib7 960 2 - - JJ cord-005453-4057qib7 960 3 PDT PDT NNP cord-005453-4057qib7 960 4 T t NN cord-005453-4057qib7 960 5 cells cell NNS cord-005453-4057qib7 960 6 were be VBD cord-005453-4057qib7 960 7 co co JJ cord-005453-4057qib7 960 8 - - JJ cord-005453-4057qib7 960 9 cultured cultured JJ cord-005453-4057qib7 960 10 with with IN cord-005453-4057qib7 960 11 irradiated irradiate VBN cord-005453-4057qib7 960 12 autologous autologous JJ cord-005453-4057qib7 960 13 monocyte monocyte NNP cord-005453-4057qib7 960 14 - - HYPH cord-005453-4057qib7 960 15 derived derive VBN cord-005453-4057qib7 960 16 dendritic dendritic JJ cord-005453-4057qib7 960 17 cells cell NNS cord-005453-4057qib7 960 18 ( ( -LRB- cord-005453-4057qib7 960 19 10:1 10:1 CD cord-005453-4057qib7 960 20 ) ) -RRB- cord-005453-4057qib7 960 21 pulsed pulse VBD cord-005453-4057qib7 960 22 with with IN cord-005453-4057qib7 960 23 WT1p WT1p NNP cord-005453-4057qib7 960 24 , , , cord-005453-4057qib7 960 25 PRAMEp PRAMEp NNS cord-005453-4057qib7 960 26 or or CC cord-005453-4057qib7 960 27 CMV CMV NNP cord-005453-4057qib7 960 28 / / SYM cord-005453-4057qib7 960 29 EBVp EBVp NNS cord-005453-4057qib7 960 30 . . . cord-005453-4057qib7 961 1 Antigen antigen NN cord-005453-4057qib7 961 2 - - HYPH cord-005453-4057qib7 961 3 specific specific JJ cord-005453-4057qib7 961 4 T t NN cord-005453-4057qib7 961 5 cells cell NNS cord-005453-4057qib7 961 6 were be VBD cord-005453-4057qib7 961 7 re re VBN cord-005453-4057qib7 961 8 - - VBN cord-005453-4057qib7 961 9 stimulated stimulate VBN cord-005453-4057qib7 961 10 on on IN cord-005453-4057qib7 961 11 Days day NNS cord-005453-4057qib7 961 12 7 7 CD cord-005453-4057qib7 961 13 and and CC cord-005453-4057qib7 961 14 14 14 CD cord-005453-4057qib7 961 15 with with IN cord-005453-4057qib7 961 16 WT1p WT1p NNP cord-005453-4057qib7 961 17 - - , cord-005453-4057qib7 961 18 or or CC cord-005453-4057qib7 961 19 PRAMEp PRAMEp NNS cord-005453-4057qib7 961 20 - - HYPH cord-005453-4057qib7 961 21 pulsed pulse VBN cord-005453-4057qib7 961 22 autologous autologous JJ cord-005453-4057qib7 961 23 PBMCs pbmc NNS cord-005453-4057qib7 961 24 or or CC cord-005453-4057qib7 961 25 with with IN cord-005453-4057qib7 961 26 CMV CMV NNP cord-005453-4057qib7 961 27 / / SYM cord-005453-4057qib7 961 28 EBVp EBVp NNS cord-005453-4057qib7 961 29 added add VBD cord-005453-4057qib7 961 30 directly directly RB cord-005453-4057qib7 961 31 to to IN cord-005453-4057qib7 961 32 the the DT cord-005453-4057qib7 961 33 culture culture NN cord-005453-4057qib7 961 34 . . . cord-005453-4057qib7 962 1 MHCtetramer MHCtetramer NNP cord-005453-4057qib7 962 2 staining staining NN cord-005453-4057qib7 962 3 was be VBD cord-005453-4057qib7 962 4 performed perform VBN cord-005453-4057qib7 962 5 on on IN cord-005453-4057qib7 962 6 Days day NNS cord-005453-4057qib7 962 7 14 14 CD cord-005453-4057qib7 962 8 and and CC cord-005453-4057qib7 962 9 21 21 CD cord-005453-4057qib7 962 10 ; ; : cord-005453-4057qib7 962 11 IFN IFN NNP cord-005453-4057qib7 962 12 - - HYPH cord-005453-4057qib7 962 13 γ γ NNP cord-005453-4057qib7 962 14 ELISpot elispot NN cord-005453-4057qib7 962 15 was be VBD cord-005453-4057qib7 962 16 conducted conduct VBN cord-005453-4057qib7 962 17 on on IN cord-005453-4057qib7 962 18 Day Day NNP cord-005453-4057qib7 962 19 21 21 CD cord-005453-4057qib7 962 20 . . . cord-005453-4057qib7 963 1 [ [ -LRB- cord-005453-4057qib7 963 2 [ [ -LRB- cord-005453-4057qib7 963 3 P057 P057 NNP cord-005453-4057qib7 963 4 Image image NN cord-005453-4057qib7 963 5 ] ] -RRB- cord-005453-4057qib7 963 6 1 1 CD cord-005453-4057qib7 963 7 . . . cord-005453-4057qib7 964 1 Functional functional JJ cord-005453-4057qib7 964 2 WT1-specific wt1-specific NN cord-005453-4057qib7 964 3 and and CC cord-005453-4057qib7 964 4 viralspecific viralspecific NNP cord-005453-4057qib7 964 5 T t NN cord-005453-4057qib7 964 6 cells cell NNS cord-005453-4057qib7 964 7 can can MD cord-005453-4057qib7 964 8 be be VB cord-005453-4057qib7 964 9 expanded expand VBN cord-005453-4057qib7 964 10 post post JJ cord-005453-4057qib7 964 11 - - JJ cord-005453-4057qib7 964 12 PDT PDT NNP cord-005453-4057qib7 964 13 ] ] -RRB- cord-005453-4057qib7 964 14 Results result NNS cord-005453-4057qib7 964 15 : : : cord-005453-4057qib7 964 16 PDT PDT NNP cord-005453-4057qib7 964 17 resulted result VBD cord-005453-4057qib7 964 18 in in IN cord-005453-4057qib7 964 19 a a DT cord-005453-4057qib7 964 20 drastic drastic JJ cord-005453-4057qib7 964 21 decrease decrease NN cord-005453-4057qib7 964 22 of of IN cord-005453-4057qib7 964 23 CD25 CD25 NNP cord-005453-4057qib7 964 24 and/ and/ NNP cord-005453-4057qib7 964 25 or or CC cord-005453-4057qib7 964 26 HLA HLA NNP cord-005453-4057qib7 964 27 - - HYPH cord-005453-4057qib7 964 28 DR DR NNP cord-005453-4057qib7 964 29 activation activation NN cord-005453-4057qib7 964 30 marker marker NN cord-005453-4057qib7 964 31 - - HYPH cord-005453-4057qib7 964 32 expressing express VBG cord-005453-4057qib7 964 33 CD4 CD4 NNP cord-005453-4057qib7 964 34 + + CC cord-005453-4057qib7 964 35 and and CC cord-005453-4057qib7 964 36 CD8 CD8 NNP cord-005453-4057qib7 964 37 + + CC cord-005453-4057qib7 964 38 T T NNP cord-005453-4057qib7 964 39 cells cell NNS cord-005453-4057qib7 964 40 . . . cord-005453-4057qib7 965 1 PDT PDT NNP cord-005453-4057qib7 965 2 - - HYPH cord-005453-4057qib7 965 3 treated treat VBN cord-005453-4057qib7 965 4 cells cell NNS cord-005453-4057qib7 965 5 showed show VBD cord-005453-4057qib7 965 6 a a DT cord-005453-4057qib7 965 7 significant significant JJ cord-005453-4057qib7 965 8 increase increase NN cord-005453-4057qib7 965 9 in in IN cord-005453-4057qib7 965 10 Background background NN cord-005453-4057qib7 965 11 : : : cord-005453-4057qib7 966 1 Acute acute JJ cord-005453-4057qib7 966 2 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 966 3 leukemia leukemia NN cord-005453-4057qib7 966 4 ( ( -LRB- cord-005453-4057qib7 966 5 ALL all DT cord-005453-4057qib7 966 6 ) ) -RRB- cord-005453-4057qib7 966 7 is be VBZ cord-005453-4057qib7 966 8 the the DT cord-005453-4057qib7 966 9 most most RBS cord-005453-4057qib7 966 10 common common JJ cord-005453-4057qib7 966 11 childhood childhood NN cord-005453-4057qib7 966 12 cancer cancer NN cord-005453-4057qib7 966 13 and and CC cord-005453-4057qib7 966 14 relapsed relapse VBN cord-005453-4057qib7 966 15 or or CC cord-005453-4057qib7 966 16 refractory refractory JJ cord-005453-4057qib7 966 17 ALL all DT cord-005453-4057qib7 966 18 is be VBZ cord-005453-4057qib7 966 19 still still RB cord-005453-4057qib7 966 20 difficult difficult JJ cord-005453-4057qib7 966 21 to to TO cord-005453-4057qib7 966 22 treat treat VB cord-005453-4057qib7 966 23 . . . cord-005453-4057qib7 967 1 Engineered engineer VBN cord-005453-4057qib7 967 2 T T NNP cord-005453-4057qib7 967 3 cells cell NNS cord-005453-4057qib7 967 4 equipped equip VBN cord-005453-4057qib7 967 5 with with IN cord-005453-4057qib7 967 6 a a DT cord-005453-4057qib7 967 7 synthetic synthetic JJ cord-005453-4057qib7 967 8 chimeric chimeric JJ cord-005453-4057qib7 967 9 antigen antigen NN cord-005453-4057qib7 967 10 receptor receptor NN cord-005453-4057qib7 967 11 ( ( -LRB- cord-005453-4057qib7 967 12 CAR car NN cord-005453-4057qib7 967 13 ) ) -RRB- cord-005453-4057qib7 967 14 targeting target VBG cord-005453-4057qib7 967 15 CD19 CD19 NNP cord-005453-4057qib7 967 16 have have VBP cord-005453-4057qib7 967 17 demonstrated demonstrate VBN cord-005453-4057qib7 967 18 remarkable remarkable JJ cord-005453-4057qib7 967 19 efficacy efficacy NN cord-005453-4057qib7 967 20 to to TO cord-005453-4057qib7 967 21 treat treat VB cord-005453-4057qib7 967 22 ALL all DT cord-005453-4057qib7 967 23 . . . cord-005453-4057qib7 968 1 However however RB cord-005453-4057qib7 968 2 natural natural JJ cord-005453-4057qib7 968 3 killer killer NN cord-005453-4057qib7 968 4 ( ( -LRB- cord-005453-4057qib7 968 5 NK NK NNP cord-005453-4057qib7 968 6 ) ) -RRB- cord-005453-4057qib7 968 7 cells cell NNS cord-005453-4057qib7 968 8 are be VBP cord-005453-4057qib7 968 9 known know VBN cord-005453-4057qib7 968 10 for for IN cord-005453-4057qib7 968 11 their -PRON- PRP$ cord-005453-4057qib7 968 12 target target NN cord-005453-4057qib7 968 13 - - HYPH cord-005453-4057qib7 968 14 independent independent JJ cord-005453-4057qib7 968 15 cytotoxic cytotoxic JJ cord-005453-4057qib7 968 16 potential potential NN cord-005453-4057qib7 968 17 without without IN cord-005453-4057qib7 968 18 induction induction NN cord-005453-4057qib7 968 19 of of IN cord-005453-4057qib7 968 20 cytokine cytokine NN cord-005453-4057qib7 968 21 release release NN cord-005453-4057qib7 968 22 syndrome syndrome NN cord-005453-4057qib7 968 23 ( ( -LRB- cord-005453-4057qib7 968 24 CRS CRS NNP cord-005453-4057qib7 968 25 ) ) -RRB- cord-005453-4057qib7 968 26 or or CC cord-005453-4057qib7 968 27 graft graft NN cord-005453-4057qib7 968 28 - - HYPH cord-005453-4057qib7 968 29 versus versus IN cord-005453-4057qib7 968 30 - - HYPH cord-005453-4057qib7 968 31 hostdisease hostdisease NN cord-005453-4057qib7 968 32 ( ( -LRB- cord-005453-4057qib7 968 33 GvHD GvHD NNP cord-005453-4057qib7 968 34 ) ) -RRB- cord-005453-4057qib7 968 35 , , , cord-005453-4057qib7 968 36 CAR CAR NNP cord-005453-4057qib7 968 37 - - HYPH cord-005453-4057qib7 968 38 NK NK NNP cord-005453-4057qib7 968 39 cells cell NNS cord-005453-4057qib7 968 40 can can MD cord-005453-4057qib7 968 41 overcome overcome VB cord-005453-4057qib7 968 42 the the DT cord-005453-4057qib7 968 43 persisting persist VBG cord-005453-4057qib7 968 44 problem problem NN cord-005453-4057qib7 968 45 in in IN cord-005453-4057qib7 968 46 the the DT cord-005453-4057qib7 968 47 therapy therapy NN cord-005453-4057qib7 968 48 with with IN cord-005453-4057qib7 968 49 CAR CAR NNP cord-005453-4057qib7 968 50 T T NNP cord-005453-4057qib7 968 51 cells cell NNS cord-005453-4057qib7 968 52 . . . cord-005453-4057qib7 969 1 As as IN cord-005453-4057qib7 969 2 the the DT cord-005453-4057qib7 969 3 use use NN cord-005453-4057qib7 969 4 of of IN cord-005453-4057qib7 969 5 viral viral JJ cord-005453-4057qib7 969 6 vector vector NN cord-005453-4057qib7 969 7 generated generate VBN cord-005453-4057qib7 969 8 CAR car NN cord-005453-4057qib7 969 9 NK NK NNP cord-005453-4057qib7 969 10 cells cell NNS cord-005453-4057qib7 969 11 is be VBZ cord-005453-4057qib7 969 12 limited limit VBN cord-005453-4057qib7 969 13 by by IN cord-005453-4057qib7 969 14 theire theire JJ cord-005453-4057qib7 969 15 genotoxicity genotoxicity NN cord-005453-4057qib7 969 16 , , , cord-005453-4057qib7 969 17 cost cost NN cord-005453-4057qib7 969 18 and and CC cord-005453-4057qib7 969 19 regulatory regulatory JJ cord-005453-4057qib7 969 20 demands demand NNS cord-005453-4057qib7 969 21 , , , cord-005453-4057qib7 969 22 we -PRON- PRP cord-005453-4057qib7 969 23 are be VBP cord-005453-4057qib7 969 24 developing develop VBG cord-005453-4057qib7 969 25 an an DT cord-005453-4057qib7 969 26 innovative innovative JJ cord-005453-4057qib7 969 27 protocol protocol NN cord-005453-4057qib7 969 28 using use VBG cord-005453-4057qib7 969 29 non non JJ cord-005453-4057qib7 969 30 - - JJ cord-005453-4057qib7 969 31 viral viral JJ cord-005453-4057qib7 969 32 Sleeping sleep VBG cord-005453-4057qib7 969 33 Beauty Beauty NNP cord-005453-4057qib7 969 34 ( ( -LRB- cord-005453-4057qib7 969 35 SB SB NNP cord-005453-4057qib7 969 36 ) ) -RRB- cord-005453-4057qib7 969 37 transposition transposition NN cord-005453-4057qib7 969 38 of of IN cord-005453-4057qib7 969 39 third third JJ cord-005453-4057qib7 969 40 party party NN cord-005453-4057qib7 969 41 NK NK NNP cord-005453-4057qib7 969 42 cells cell NNS cord-005453-4057qib7 969 43 as as IN cord-005453-4057qib7 969 44 a a DT cord-005453-4057qib7 969 45 source source NN cord-005453-4057qib7 969 46 to to TO cord-005453-4057qib7 969 47 produce produce VB cord-005453-4057qib7 969 48 ' ' '' cord-005453-4057qib7 969 49 off off IN cord-005453-4057qib7 969 50 the the DT cord-005453-4057qib7 969 51 shelf shelf NN cord-005453-4057qib7 969 52 ' ' '' cord-005453-4057qib7 969 53 CAR car NN cord-005453-4057qib7 969 54 - - HYPH cord-005453-4057qib7 969 55 engineered engineer VBN cord-005453-4057qib7 969 56 cell cell NN cord-005453-4057qib7 969 57 products product NNS cord-005453-4057qib7 969 58 . . . cord-005453-4057qib7 970 1 Methods method NNS cord-005453-4057qib7 970 2 : : : cord-005453-4057qib7 970 3 NK NK NNP cord-005453-4057qib7 970 4 cells cell NNS cord-005453-4057qib7 970 5 are be VBP cord-005453-4057qib7 970 6 isolated isolate VBN cord-005453-4057qib7 970 7 from from IN cord-005453-4057qib7 970 8 peripheral peripheral JJ cord-005453-4057qib7 970 9 blood blood NN cord-005453-4057qib7 970 10 mononuclear mononuclear NN cord-005453-4057qib7 970 11 cells cell NNS cord-005453-4057qib7 970 12 ( ( -LRB- cord-005453-4057qib7 970 13 PBMCs pbmc NNS cord-005453-4057qib7 970 14 ) ) -RRB- cord-005453-4057qib7 970 15 using use VBG cord-005453-4057qib7 970 16 CD56 CD56 NNP cord-005453-4057qib7 970 17 selection selection NN cord-005453-4057qib7 970 18 kits kit NNS cord-005453-4057qib7 970 19 . . . cord-005453-4057qib7 971 1 They -PRON- PRP cord-005453-4057qib7 971 2 are be VBP cord-005453-4057qib7 971 3 successfully successfully RB cord-005453-4057qib7 971 4 expanded expand VBN cord-005453-4057qib7 971 5 ex ex FW cord-005453-4057qib7 971 6 vivo vivo NN cord-005453-4057qib7 971 7 with with IN cord-005453-4057qib7 971 8 IL-15 IL-15 NNP cord-005453-4057qib7 971 9 cytokine cytokine JJ cord-005453-4057qib7 971 10 stimulation stimulation NN cord-005453-4057qib7 971 11 under under IN cord-005453-4057qib7 971 12 feeder feeder NN cord-005453-4057qib7 971 13 - - HYPH cord-005453-4057qib7 971 14 cell cell NN cord-005453-4057qib7 971 15 free free JJ cord-005453-4057qib7 971 16 conditions condition NNS cord-005453-4057qib7 971 17 . . . cord-005453-4057qib7 972 1 After after IN cord-005453-4057qib7 972 2 few few JJ cord-005453-4057qib7 972 3 days day NNS cord-005453-4057qib7 972 4 of of IN cord-005453-4057qib7 972 5 expansion expansion NN cord-005453-4057qib7 972 6 NK NK NNP cord-005453-4057qib7 972 7 cells cell NNS cord-005453-4057qib7 972 8 are be VBP cord-005453-4057qib7 972 9 electroporated electroporate VBN cord-005453-4057qib7 972 10 using use VBG cord-005453-4057qib7 972 11 pmaxGFP pmaxgfp NN cord-005453-4057qib7 972 12 . . . cord-005453-4057qib7 973 1 Transfection transfection NN cord-005453-4057qib7 973 2 efficiency efficiency NN cord-005453-4057qib7 973 3 and and CC cord-005453-4057qib7 973 4 percent percent NN cord-005453-4057qib7 973 5 of of IN cord-005453-4057qib7 973 6 living living NN cord-005453-4057qib7 973 7 cells cell NNS cord-005453-4057qib7 973 8 after after IN cord-005453-4057qib7 973 9 electroporation electroporation NN cord-005453-4057qib7 973 10 is be VBZ cord-005453-4057qib7 973 11 analyzed analyze VBN cord-005453-4057qib7 973 12 by by IN cord-005453-4057qib7 973 13 flow flow NN cord-005453-4057qib7 973 14 cytometry cytometry NN cord-005453-4057qib7 973 15 . . . cord-005453-4057qib7 974 1 Transposition transposition NN cord-005453-4057qib7 974 2 based base VBN cord-005453-4057qib7 974 3 nucleofection nucleofection NN cord-005453-4057qib7 974 4 using use VBG cord-005453-4057qib7 974 5 an an DT cord-005453-4057qib7 974 6 SB100X sb100x NN cord-005453-4057qib7 974 7 mRNA mrna NN cord-005453-4057qib7 974 8 and and CC cord-005453-4057qib7 974 9 a a DT cord-005453-4057qib7 974 10 minicircles minicircles FW cord-005453-4057qib7 974 11 ( ( -LRB- cord-005453-4057qib7 974 12 MC MC NNP cord-005453-4057qib7 974 13 ) ) -RRB- cord-005453-4057qib7 974 14 DNA dna NN cord-005453-4057qib7 974 15 vector vector NN cord-005453-4057qib7 974 16 is be VBZ cord-005453-4057qib7 974 17 performed perform VBN cord-005453-4057qib7 974 18 at at IN cord-005453-4057qib7 974 19 different different JJ cord-005453-4057qib7 974 20 time time NN cord-005453-4057qib7 974 21 points point NNS cord-005453-4057qib7 974 22 after after IN cord-005453-4057qib7 974 23 NK NK NNP cord-005453-4057qib7 974 24 cell cell NN cord-005453-4057qib7 974 25 isolation isolation NN cord-005453-4057qib7 974 26 . . . cord-005453-4057qib7 975 1 The the DT cord-005453-4057qib7 975 2 transient transient JJ cord-005453-4057qib7 975 3 MC MC NNP cord-005453-4057qib7 975 4 - - HYPH cord-005453-4057qib7 975 5 Venus Venus NNP cord-005453-4057qib7 975 6 longtime longtime JJ cord-005453-4057qib7 975 7 expansion expansion NN cord-005453-4057qib7 975 8 and and CC cord-005453-4057qib7 975 9 the the DT cord-005453-4057qib7 975 10 viability viability NN cord-005453-4057qib7 975 11 after after IN cord-005453-4057qib7 975 12 SB100X sb100x NN cord-005453-4057qib7 975 13 based base VBN cord-005453-4057qib7 975 14 nucleofection nucleofection NN cord-005453-4057qib7 975 15 is be VBZ cord-005453-4057qib7 975 16 measured measure VBN cord-005453-4057qib7 975 17 over over IN cord-005453-4057qib7 975 18 two two CD cord-005453-4057qib7 975 19 weeks week NNS cord-005453-4057qib7 975 20 . . . cord-005453-4057qib7 976 1 Furthermore furthermore RB cord-005453-4057qib7 976 2 , , , cord-005453-4057qib7 976 3 α α NN cord-005453-4057qib7 976 4 - - HYPH cord-005453-4057qib7 976 5 retroviral retroviral JJ cord-005453-4057qib7 976 6 ( ( -LRB- cord-005453-4057qib7 976 7 α α NN cord-005453-4057qib7 976 8 - - HYPH cord-005453-4057qib7 976 9 RV RV NNP cord-005453-4057qib7 976 10 ) ) -RRB- cord-005453-4057qib7 976 11 CD19-CAR cd19-car JJ cord-005453-4057qib7 976 12 transduction transduction NN cord-005453-4057qib7 976 13 of of IN cord-005453-4057qib7 976 14 NK NK NNP cord-005453-4057qib7 976 15 cells cell NNS cord-005453-4057qib7 976 16 with with IN cord-005453-4057qib7 976 17 different different JJ cord-005453-4057qib7 976 18 viral viral JJ cord-005453-4057qib7 976 19 amounts amount NNS cord-005453-4057qib7 976 20 ( ( -LRB- cord-005453-4057qib7 976 21 MOI MOI NNP cord-005453-4057qib7 976 22 ) ) -RRB- cord-005453-4057qib7 976 23 is be VBZ cord-005453-4057qib7 976 24 conducted conduct VBN cord-005453-4057qib7 976 25 and and CC cord-005453-4057qib7 976 26 the the DT cord-005453-4057qib7 976 27 cytotoxicity cytotoxicity NN cord-005453-4057qib7 976 28 of of IN cord-005453-4057qib7 976 29 the the DT cord-005453-4057qib7 976 30 engineered engineer VBN cord-005453-4057qib7 976 31 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 976 32 - - HYPH cord-005453-4057qib7 976 33 NK NK NNP cord-005453-4057qib7 976 34 cells cell NNS cord-005453-4057qib7 976 35 against against IN cord-005453-4057qib7 976 36 the the DT cord-005453-4057qib7 976 37 CD19 CD19 NNP cord-005453-4057qib7 976 38 positiv positiv JJ cord-005453-4057qib7 976 39 cell cell NN cord-005453-4057qib7 976 40 line line NN cord-005453-4057qib7 976 41 SupB15 SupB15 NNP cord-005453-4057qib7 976 42 is be VBZ cord-005453-4057qib7 976 43 addressed address VBN cord-005453-4057qib7 976 44 . . . cord-005453-4057qib7 977 1 Results result NNS cord-005453-4057qib7 977 2 : : : cord-005453-4057qib7 978 1 For for IN cord-005453-4057qib7 978 2 an an DT cord-005453-4057qib7 978 3 α α NN cord-005453-4057qib7 978 4 - - HYPH cord-005453-4057qib7 978 5 RV rv NN cord-005453-4057qib7 978 6 CD19-CAR cd19-car JJ cord-005453-4057qib7 978 7 transduction transduction NN cord-005453-4057qib7 978 8 of of IN cord-005453-4057qib7 978 9 maximal maximal JJ cord-005453-4057qib7 978 10 1x10 1x10 CD cord-005453-4057qib7 978 11 4 4 CD cord-005453-4057qib7 978 12 NK NK NNP cord-005453-4057qib7 978 13 cells cell NNS cord-005453-4057qib7 978 14 we -PRON- PRP cord-005453-4057qib7 978 15 could could MD cord-005453-4057qib7 978 16 show show VB cord-005453-4057qib7 978 17 transduction transduction NN cord-005453-4057qib7 978 18 efficiency efficiency NN cord-005453-4057qib7 978 19 of of IN cord-005453-4057qib7 978 20 68,96 68,96 CD cord-005453-4057qib7 978 21 % % NN cord-005453-4057qib7 978 22 for for IN cord-005453-4057qib7 978 23 MOI10 MOI10 NNP cord-005453-4057qib7 978 24 . . . cord-005453-4057qib7 979 1 The the DT cord-005453-4057qib7 979 2 α α NN cord-005453-4057qib7 979 3 - - HYPH cord-005453-4057qib7 979 4 RV RV NNP cord-005453-4057qib7 979 5 CD19-CAR cd19-car NN cord-005453-4057qib7 979 6 modified modify VBN cord-005453-4057qib7 979 7 NK NK NNP cord-005453-4057qib7 979 8 cells cell NNS cord-005453-4057qib7 979 9 had have VBD cord-005453-4057qib7 979 10 a a DT cord-005453-4057qib7 979 11 high high JJ cord-005453-4057qib7 979 12 killing killing NN cord-005453-4057qib7 979 13 activity activity NN cord-005453-4057qib7 979 14 against against IN cord-005453-4057qib7 979 15 CD19 CD19 NNP cord-005453-4057qib7 979 16 positiv positiv JJ cord-005453-4057qib7 979 17 SupB15 SupB15 NNP cord-005453-4057qib7 979 18 cells cell NNS cord-005453-4057qib7 980 1 ( ( -LRB- cord-005453-4057qib7 980 2 E e NN cord-005453-4057qib7 980 3 : : : cord-005453-4057qib7 980 4 T t NN cord-005453-4057qib7 980 5 ration ration NN cord-005453-4057qib7 980 6 1:1 1:1 CD cord-005453-4057qib7 980 7 90,85 90,85 CD cord-005453-4057qib7 980 8 % % NN cord-005453-4057qib7 980 9 ) ) -RRB- cord-005453-4057qib7 980 10 compared compare VBN cord-005453-4057qib7 980 11 to to IN cord-005453-4057qib7 980 12 CD19 CD19 NNP cord-005453-4057qib7 980 13 negativ negativ NNP cord-005453-4057qib7 980 14 K562 k562 CD cord-005453-4057qib7 980 15 cell cell NN cord-005453-4057qib7 980 16 lines line NNS cord-005453-4057qib7 980 17 ( ( -LRB- cord-005453-4057qib7 980 18 E e NN cord-005453-4057qib7 980 19 : : : cord-005453-4057qib7 980 20 T t NN cord-005453-4057qib7 980 21 ration ration NN cord-005453-4057qib7 980 22 1:1 1:1 CD cord-005453-4057qib7 980 23 16,42 16,42 CD cord-005453-4057qib7 980 24 % % NN cord-005453-4057qib7 980 25 ) ) -RRB- cord-005453-4057qib7 980 26 and and CC cord-005453-4057qib7 980 27 the the DT cord-005453-4057qib7 980 28 non non JJ cord-005453-4057qib7 980 29 - - JJ cord-005453-4057qib7 980 30 transduced transduced JJ cord-005453-4057qib7 980 31 NK NK NNP cord-005453-4057qib7 980 32 cells cell NNS cord-005453-4057qib7 981 1 ( ( -LRB- cord-005453-4057qib7 981 2 E e NN cord-005453-4057qib7 981 3 : : : cord-005453-4057qib7 981 4 T t NN cord-005453-4057qib7 981 5 ratio ratio NN cord-005453-4057qib7 981 6 1:1 1:1 CD cord-005453-4057qib7 981 7 9,03 9,03 CD cord-005453-4057qib7 981 8 % % NN cord-005453-4057qib7 981 9 ) ) -RRB- cord-005453-4057qib7 981 10 . . . cord-005453-4057qib7 982 1 In in IN cord-005453-4057qib7 982 2 first first JJ cord-005453-4057qib7 982 3 experiments experiment NNS cord-005453-4057qib7 982 4 with with IN cord-005453-4057qib7 982 5 pmaxGFP pmaxgfp NN cord-005453-4057qib7 982 6 vector vector NN cord-005453-4057qib7 982 7 based base VBN cord-005453-4057qib7 982 8 nucleofection nucleofection NN cord-005453-4057qib7 982 9 , , , cord-005453-4057qib7 982 10 we -PRON- PRP cord-005453-4057qib7 982 11 could could MD cord-005453-4057qib7 982 12 show show VB cord-005453-4057qib7 982 13 an an DT cord-005453-4057qib7 982 14 increasing increase VBG cord-005453-4057qib7 982 15 efficiency efficiency NN cord-005453-4057qib7 982 16 of of IN cord-005453-4057qib7 982 17 55,9 55,9 CD cord-005453-4057qib7 982 18 % % NN cord-005453-4057qib7 982 19 48h 48h CD cord-005453-4057qib7 982 20 post post NN cord-005453-4057qib7 982 21 electroporation electroporation NN cord-005453-4057qib7 982 22 with with IN cord-005453-4057qib7 982 23 a a DT cord-005453-4057qib7 982 24 only only JJ cord-005453-4057qib7 982 25 slightly slightly RB cord-005453-4057qib7 982 26 decreas decrea NNS cord-005453-4057qib7 982 27 of of IN cord-005453-4057qib7 982 28 living living NN cord-005453-4057qib7 982 29 cells cell NNS cord-005453-4057qib7 982 30 ( ( -LRB- cord-005453-4057qib7 982 31 21,5 21,5 CD cord-005453-4057qib7 982 32 % % NN cord-005453-4057qib7 982 33 ) ) -RRB- cord-005453-4057qib7 982 34 comparing compare VBG cord-005453-4057qib7 982 35 to to IN cord-005453-4057qib7 982 36 the the DT cord-005453-4057qib7 982 37 non non JJ cord-005453-4057qib7 982 38 - - JJ cord-005453-4057qib7 982 39 electroporated electroporated JJ cord-005453-4057qib7 982 40 NK NK NNP cord-005453-4057qib7 982 41 cell cell NN cord-005453-4057qib7 982 42 viability viability NN cord-005453-4057qib7 982 43 . . . cord-005453-4057qib7 983 1 Using use VBG cord-005453-4057qib7 983 2 SB100X SB100X NNP cord-005453-4057qib7 983 3 mRNA mRNA NNP cord-005453-4057qib7 983 4 with with IN cord-005453-4057qib7 983 5 MC MC NNP cord-005453-4057qib7 983 6 - - HYPH cord-005453-4057qib7 983 7 Venus Venus NNP cord-005453-4057qib7 983 8 DNA DNA NNP cord-005453-4057qib7 983 9 we -PRON- PRP cord-005453-4057qib7 983 10 electrotransfected electrotransfecte VBD cord-005453-4057qib7 983 11 1x10 1x10 CD cord-005453-4057qib7 983 12 6 6 CD cord-005453-4057qib7 983 13 NK NK NNP cord-005453-4057qib7 983 14 cells cell NNS cord-005453-4057qib7 983 15 after after IN cord-005453-4057qib7 983 16 fews few NNS cord-005453-4057qib7 983 17 days day NNS cord-005453-4057qib7 983 18 of of IN cord-005453-4057qib7 983 19 cultivation cultivation NN cord-005453-4057qib7 983 20 and and CC cord-005453-4057qib7 983 21 we -PRON- PRP cord-005453-4057qib7 983 22 reached reach VBD cord-005453-4057qib7 983 23 36,6 36,6 CD cord-005453-4057qib7 983 24 % % NN cord-005453-4057qib7 983 25 of of IN cord-005453-4057qib7 983 26 transfected transfecte VBN cord-005453-4057qib7 983 27 NK NK NNP cord-005453-4057qib7 983 28 cells cell NNS cord-005453-4057qib7 983 29 24h 24h NNS cord-005453-4057qib7 983 30 post post NN cord-005453-4057qib7 983 31 electroporation electroporation NN cord-005453-4057qib7 983 32 and and CC cord-005453-4057qib7 983 33 a a DT cord-005453-4057qib7 983 34 transient transient JJ cord-005453-4057qib7 983 35 expression expression NN cord-005453-4057qib7 983 36 of of IN cord-005453-4057qib7 983 37 MC MC NNP cord-005453-4057qib7 983 38 - - HYPH cord-005453-4057qib7 983 39 Venus Venus NNP cord-005453-4057qib7 983 40 positive positive JJ cord-005453-4057qib7 983 41 NK NK NNP cord-005453-4057qib7 983 42 cells cell NNS cord-005453-4057qib7 983 43 up up IN cord-005453-4057qib7 983 44 to to IN cord-005453-4057qib7 983 45 54,6 54,6 CD cord-005453-4057qib7 983 46 % % NN cord-005453-4057qib7 983 47 efficiency efficiency NN cord-005453-4057qib7 983 48 with with IN cord-005453-4057qib7 983 49 an an DT cord-005453-4057qib7 983 50 increasing increase VBG cord-005453-4057qib7 983 51 rate rate NN cord-005453-4057qib7 983 52 of of IN cord-005453-4057qib7 983 53 live live JJ cord-005453-4057qib7 983 54 cells cell NNS cord-005453-4057qib7 983 55 over over IN cord-005453-4057qib7 983 56 14 14 CD cord-005453-4057qib7 983 57 days day NNS cord-005453-4057qib7 983 58 after after IN cord-005453-4057qib7 983 59 electroporation electroporation NN cord-005453-4057qib7 983 60 . . . cord-005453-4057qib7 984 1 Conclusions conclusion NNS cord-005453-4057qib7 984 2 : : : cord-005453-4057qib7 985 1 The the DT cord-005453-4057qib7 985 2 Sleeping sleep VBG cord-005453-4057qib7 985 3 Beauty Beauty NNP cord-005453-4057qib7 985 4 based base VBN cord-005453-4057qib7 985 5 nucleofection nucleofection NN cord-005453-4057qib7 985 6 of of IN cord-005453-4057qib7 985 7 NK NK NNP cord-005453-4057qib7 985 8 cells cell NNS cord-005453-4057qib7 985 9 is be VBZ cord-005453-4057qib7 985 10 a a DT cord-005453-4057qib7 985 11 very very RB cord-005453-4057qib7 985 12 promising promising JJ cord-005453-4057qib7 985 13 non non JJ cord-005453-4057qib7 985 14 - - JJ cord-005453-4057qib7 985 15 viral viral JJ cord-005453-4057qib7 985 16 method method NN cord-005453-4057qib7 985 17 to to TO cord-005453-4057qib7 985 18 generate generate VB cord-005453-4057qib7 985 19 more more RBR cord-005453-4057qib7 985 20 easy easy JJ cord-005453-4057qib7 985 21 , , , cord-005453-4057qib7 985 22 safer safe JJR cord-005453-4057qib7 985 23 and and CC cord-005453-4057qib7 985 24 higher high JJR cord-005453-4057qib7 985 25 amounts amount NNS cord-005453-4057qib7 985 26 of of IN cord-005453-4057qib7 985 27 genetically genetically RB cord-005453-4057qib7 985 28 modified modify VBN cord-005453-4057qib7 985 29 third third JJ cord-005453-4057qib7 985 30 party party NN cord-005453-4057qib7 985 31 NK NK NNP cord-005453-4057qib7 985 32 cells cell NNS cord-005453-4057qib7 985 33 for for IN cord-005453-4057qib7 985 34 therapy therapy NN cord-005453-4057qib7 985 35 of of IN cord-005453-4057qib7 985 36 ALL all DT cord-005453-4057qib7 985 37 and and CC cord-005453-4057qib7 985 38 has have VBZ cord-005453-4057qib7 985 39 also also RB cord-005453-4057qib7 985 40 a a DT cord-005453-4057qib7 985 41 broad broad JJ cord-005453-4057qib7 985 42 range range NN cord-005453-4057qib7 985 43 of of IN cord-005453-4057qib7 985 44 clinical clinical JJ cord-005453-4057qib7 985 45 applications application NNS cord-005453-4057qib7 985 46 . . . cord-005453-4057qib7 986 1 Disclosure disclosure NN cord-005453-4057qib7 986 2 : : : cord-005453-4057qib7 987 1 Winfried Winfried NNP cord-005453-4057qib7 987 2 S. S. NNP cord-005453-4057qib7 987 3 Wels Wels NNP cord-005453-4057qib7 987 4 is be VBZ cord-005453-4057qib7 987 5 an an DT cord-005453-4057qib7 987 6 inventor inventor NN cord-005453-4057qib7 987 7 on on IN cord-005453-4057qib7 987 8 a a DT cord-005453-4057qib7 987 9 patent patent NN cord-005453-4057qib7 987 10 describing describe VBG cord-005453-4057qib7 987 11 chimeric chimeric JJ cord-005453-4057qib7 987 12 antigen antigen NN cord-005453-4057qib7 987 13 receptors receptor NNS cord-005453-4057qib7 987 14 with with IN cord-005453-4057qib7 987 15 an an DT cord-005453-4057qib7 987 16 optimized optimize VBN cord-005453-4057qib7 987 17 hinge hinge NN cord-005453-4057qib7 987 18 region region NN cord-005453-4057qib7 987 19 . . . cord-005453-4057qib7 988 1 Axel Axel NNP cord-005453-4057qib7 988 2 Schambach Schambach NNP cord-005453-4057qib7 988 3 is be VBZ cord-005453-4057qib7 988 4 an an DT cord-005453-4057qib7 988 5 inventor inventor NN cord-005453-4057qib7 988 6 on on IN cord-005453-4057qib7 988 7 a a DT cord-005453-4057qib7 988 8 patent patent NN cord-005453-4057qib7 988 9 describing describe VBG cord-005453-4057qib7 988 10 alpharetroviral alpharetroviral JJ cord-005453-4057qib7 988 11 SIN sin NN cord-005453-4057qib7 988 12 vectors vector NNS cord-005453-4057qib7 988 13 . . . cord-005453-4057qib7 989 1 Michael Michael NNP cord-005453-4057qib7 989 2 Hudecek Hudecek NNP cord-005453-4057qib7 989 3 and and CC cord-005453-4057qib7 989 4 Zoltan Zoltan NNP cord-005453-4057qib7 989 5 Ivics Ivics NNP cord-005453-4057qib7 989 6 are be VBP cord-005453-4057qib7 989 7 inventors inventor NNS cord-005453-4057qib7 989 8 on on IN cord-005453-4057qib7 989 9 patents patent NNS cord-005453-4057qib7 989 10 related relate VBN cord-005453-4057qib7 989 11 to to IN cord-005453-4057qib7 989 12 Sleeping sleep VBG cord-005453-4057qib7 989 13 Beaut Beaut NNP cord-005453-4057qib7 989 14 gene gene NN cord-005453-4057qib7 989 15 transfer transfer NN cord-005453-4057qib7 989 16 technology technology NN cord-005453-4057qib7 989 17 . . . cord-005453-4057qib7 990 1 The the DT cord-005453-4057qib7 990 2 remaining remain VBG cord-005453-4057qib7 990 3 authors author NNS cord-005453-4057qib7 990 4 have have VBP cord-005453-4057qib7 990 5 nothing nothing NN cord-005453-4057qib7 990 6 to to TO cord-005453-4057qib7 990 7 disclose disclose VB cord-005453-4057qib7 990 8 . . . cord-005453-4057qib7 991 1 Background background NN cord-005453-4057qib7 991 2 : : : cord-005453-4057qib7 992 1 Mature mature JJ cord-005453-4057qib7 992 2 immune immune JJ cord-005453-4057qib7 992 3 cells cell NNS cord-005453-4057qib7 992 4 from from IN cord-005453-4057qib7 992 5 the the DT cord-005453-4057qib7 992 6 stem stem NN cord-005453-4057qib7 992 7 cell cell NN cord-005453-4057qib7 992 8 graft graft NN cord-005453-4057qib7 992 9 are be VBP cord-005453-4057qib7 992 10 essential essential JJ cord-005453-4057qib7 992 11 for for IN cord-005453-4057qib7 992 12 the the DT cord-005453-4057qib7 992 13 graft graft NN cord-005453-4057qib7 992 14 - - HYPH cord-005453-4057qib7 992 15 versus versus IN cord-005453-4057qib7 992 16 - - HYPH cord-005453-4057qib7 992 17 tumor tumor NN cord-005453-4057qib7 992 18 ( ( -LRB- cord-005453-4057qib7 992 19 GVT GVT NNP cord-005453-4057qib7 992 20 ) ) -RRB- cord-005453-4057qib7 992 21 effect effect NN cord-005453-4057qib7 992 22 to to TO cord-005453-4057qib7 992 23 eliminate eliminate VB cord-005453-4057qib7 992 24 residual residual JJ cord-005453-4057qib7 992 25 malignant malignant JJ cord-005453-4057qib7 992 26 cells cell NNS cord-005453-4057qib7 992 27 after after IN cord-005453-4057qib7 992 28 hematopoietic hematopoietic JJ cord-005453-4057qib7 992 29 stem stem NN cord-005453-4057qib7 992 30 cell cell NN cord-005453-4057qib7 992 31 transplantation transplantation NN cord-005453-4057qib7 992 32 ( ( -LRB- cord-005453-4057qib7 992 33 HSCT HSCT NNP cord-005453-4057qib7 992 34 ) ) -RRB- cord-005453-4057qib7 992 35 , , , cord-005453-4057qib7 992 36 but but CC cord-005453-4057qib7 992 37 donor donor NN cord-005453-4057qib7 992 38 cells cell NNS cord-005453-4057qib7 992 39 are be VBP cord-005453-4057qib7 992 40 also also RB cord-005453-4057qib7 992 41 involved involve VBN cord-005453-4057qib7 992 42 in in IN cord-005453-4057qib7 992 43 complications complication NNS cord-005453-4057qib7 992 44 such such JJ cord-005453-4057qib7 992 45 as as IN cord-005453-4057qib7 992 46 graft graft NN cord-005453-4057qib7 992 47 - - HYPH cord-005453-4057qib7 992 48 versus versus IN cord-005453-4057qib7 992 49 - - HYPH cord-005453-4057qib7 992 50 host host NN cord-005453-4057qib7 992 51 disease disease NN cord-005453-4057qib7 992 52 ( ( -LRB- cord-005453-4057qib7 992 53 GVHD GVHD NNP cord-005453-4057qib7 992 54 ) ) -RRB- cord-005453-4057qib7 992 55 . . . cord-005453-4057qib7 993 1 Methods method NNS cord-005453-4057qib7 993 2 : : : cord-005453-4057qib7 994 1 We -PRON- PRP cord-005453-4057qib7 994 2 performed perform VBD cord-005453-4057qib7 994 3 a a DT cord-005453-4057qib7 994 4 prospective prospective JJ cord-005453-4057qib7 994 5 study study NN cord-005453-4057qib7 994 6 of of IN cord-005453-4057qib7 994 7 the the DT cord-005453-4057qib7 994 8 detailed detailed JJ cord-005453-4057qib7 994 9 graft graft NN cord-005453-4057qib7 994 10 composition composition NN cord-005453-4057qib7 994 11 in in IN cord-005453-4057qib7 994 12 102 102 CD cord-005453-4057qib7 994 13 recipients recipient NNS cord-005453-4057qib7 994 14 of of IN cord-005453-4057qib7 994 15 peripheral peripheral JJ cord-005453-4057qib7 994 16 blood blood NN cord-005453-4057qib7 994 17 stem stem NN cord-005453-4057qib7 994 18 cells cell NNS cord-005453-4057qib7 994 19 ( ( -LRB- cord-005453-4057qib7 994 20 PBSC PBSC NNP cord-005453-4057qib7 994 21 ) ) -RRB- cord-005453-4057qib7 994 22 or or CC cord-005453-4057qib7 994 23 bone bone NN cord-005453-4057qib7 994 24 marrow marrow NN cord-005453-4057qib7 994 25 ( ( -LRB- cord-005453-4057qib7 994 26 BM BM NNP cord-005453-4057qib7 994 27 ) ) -RRB- cord-005453-4057qib7 994 28 in in IN cord-005453-4057qib7 994 29 order order NN cord-005453-4057qib7 994 30 to to TO cord-005453-4057qib7 994 31 identify identify VB cord-005453-4057qib7 994 32 correlations correlation NNS cord-005453-4057qib7 994 33 to to IN cord-005453-4057qib7 994 34 clinical clinical JJ cord-005453-4057qib7 994 35 outcomes outcome NNS cord-005453-4057qib7 994 36 , , , cord-005453-4057qib7 994 37 table table NN cord-005453-4057qib7 994 38 1 1 CD cord-005453-4057qib7 994 39 . . . cord-005453-4057qib7 995 1 Grafts graft NNS cord-005453-4057qib7 995 2 were be VBD cord-005453-4057qib7 995 3 characterized characterize VBN cord-005453-4057qib7 995 4 with with IN cord-005453-4057qib7 995 5 concentrations concentration NNS cord-005453-4057qib7 995 6 of of IN cord-005453-4057qib7 995 7 T t NN cord-005453-4057qib7 995 8 cells cell NNS cord-005453-4057qib7 995 9 and and CC cord-005453-4057qib7 995 10 NK NK NNP cord-005453-4057qib7 995 11 cells cell NNS cord-005453-4057qib7 995 12 together together RB cord-005453-4057qib7 995 13 with with IN cord-005453-4057qib7 995 14 a a DT cord-005453-4057qib7 995 15 multi multi JJ cord-005453-4057qib7 995 16 - - JJ cord-005453-4057qib7 995 17 color color JJ cord-005453-4057qib7 995 18 flow flow NN cord-005453-4057qib7 995 19 cytometry cytometry NN cord-005453-4057qib7 995 20 panel panel NN cord-005453-4057qib7 995 21 with with IN cord-005453-4057qib7 995 22 staining stain VBG cord-005453-4057qib7 995 23 for for IN cord-005453-4057qib7 995 24 TCRαβ TCRαβ NNP cord-005453-4057qib7 995 25 , , , cord-005453-4057qib7 995 26 TCRγδ TCRγδ NNP cord-005453-4057qib7 995 27 , , , cord-005453-4057qib7 995 28 Vδ1 Vδ1 NNP cord-005453-4057qib7 995 29 , , , cord-005453-4057qib7 995 30 Vδ2 Vδ2 NNP cord-005453-4057qib7 995 31 , , , cord-005453-4057qib7 995 32 CD3 CD3 NNP cord-005453-4057qib7 995 33 , , , cord-005453-4057qib7 995 34 CD4 CD4 NNP cord-005453-4057qib7 995 35 , , , cord-005453-4057qib7 995 36 CD8 CD8 NNP cord-005453-4057qib7 995 37 , , , cord-005453-4057qib7 995 38 HLA HLA NNP cord-005453-4057qib7 995 39 - - HYPH cord-005453-4057qib7 995 40 DR DR NNP cord-005453-4057qib7 995 41 , , , cord-005453-4057qib7 995 42 CD196 CD196 NNP cord-005453-4057qib7 995 43 , , , cord-005453-4057qib7 995 44 CD45RO CD45RO NNP cord-005453-4057qib7 995 45 , , , cord-005453-4057qib7 995 46 CD45RA CD45RA NNP cord-005453-4057qib7 995 47 , , , cord-005453-4057qib7 995 48 CD16 CD16 NNP cord-005453-4057qib7 995 49 , , , cord-005453-4057qib7 995 50 CD56 CD56 NNP cord-005453-4057qib7 995 51 , , , cord-005453-4057qib7 995 52 CD337 CD337 NNP cord-005453-4057qib7 995 53 and and CC cord-005453-4057qib7 995 54 CD314 CD314 NNP cord-005453-4057qib7 995 55 for for IN cord-005453-4057qib7 995 56 detailed detailed JJ cord-005453-4057qib7 995 57 immune immune JJ cord-005453-4057qib7 995 58 phenotyping phenotyping NN cord-005453-4057qib7 995 59 . . . cord-005453-4057qib7 996 1 Cell cell NN cord-005453-4057qib7 996 2 contents content NNS cord-005453-4057qib7 996 3 in in IN cord-005453-4057qib7 996 4 stem stem NN cord-005453-4057qib7 996 5 cell cell NN cord-005453-4057qib7 996 6 grafts graft NNS cord-005453-4057qib7 996 7 were be VBD cord-005453-4057qib7 996 8 analyzed analyze VBN cord-005453-4057qib7 996 9 both both CC cord-005453-4057qib7 996 10 as as IN cord-005453-4057qib7 996 11 fractions fraction NNS cord-005453-4057qib7 996 12 of of IN cord-005453-4057qib7 996 13 CD45 CD45 NNP cord-005453-4057qib7 996 14 positive positive JJ cord-005453-4057qib7 996 15 lymphocytes lymphocyte NNS cord-005453-4057qib7 996 16 and and CC cord-005453-4057qib7 996 17 as as IN cord-005453-4057qib7 996 18 absolute absolute JJ cord-005453-4057qib7 996 19 concentrations concentration NNS cord-005453-4057qib7 996 20 converted convert VBN cord-005453-4057qib7 996 21 to to IN cord-005453-4057qib7 996 22 transplanted transplant VBN cord-005453-4057qib7 996 23 cells/ cells/ CD cord-005453-4057qib7 996 24 kg kg NNS cord-005453-4057qib7 996 25 . . . cord-005453-4057qib7 997 1 Fractions fraction NNS cord-005453-4057qib7 997 2 were be VBD cord-005453-4057qib7 997 3 evaluated evaluate VBN cord-005453-4057qib7 997 4 in in IN cord-005453-4057qib7 997 5 patients patient NNS cord-005453-4057qib7 997 6 receiving receive VBG cord-005453-4057qib7 997 7 both both DT cord-005453-4057qib7 997 8 BM BM NNP cord-005453-4057qib7 997 9 and and CC cord-005453-4057qib7 997 10 PBSC PBSC NNP cord-005453-4057qib7 997 11 ( ( -LRB- cord-005453-4057qib7 997 12 n=102 n=102 NNP cord-005453-4057qib7 997 13 ) ) -RRB- cord-005453-4057qib7 997 14 , , , cord-005453-4057qib7 997 15 while while IN cord-005453-4057qib7 997 16 concentrations concentration NNS cord-005453-4057qib7 997 17 ( ( -LRB- cord-005453-4057qib7 997 18 cells cell NNS cord-005453-4057qib7 997 19 / / SYM cord-005453-4057qib7 997 20 kg kg NN cord-005453-4057qib7 997 21 ) ) -RRB- cord-005453-4057qib7 997 22 were be VBD cord-005453-4057qib7 997 23 only only RB cord-005453-4057qib7 997 24 analyzed analyze VBN cord-005453-4057qib7 997 25 in in IN cord-005453-4057qib7 997 26 patients patient NNS cord-005453-4057qib7 997 27 transplanted transplant VBN cord-005453-4057qib7 997 28 with with IN cord-005453-4057qib7 997 29 PBSC PBSC NNP cord-005453-4057qib7 997 30 ( ( -LRB- cord-005453-4057qib7 997 31 n=88 n=88 NN cord-005453-4057qib7 997 32 ) ) -RRB- cord-005453-4057qib7 997 33 . . . cord-005453-4057qib7 998 1 Table table NN cord-005453-4057qib7 998 2 ] ] -RRB- cord-005453-4057qib7 998 3 1 1 CD cord-005453-4057qib7 998 4 . . . cord-005453-4057qib7 999 1 Table table NN cord-005453-4057qib7 999 2 1 1 CD cord-005453-4057qib7 999 3 ] ] -RRB- cord-005453-4057qib7 999 4 [ [ -LRB- cord-005453-4057qib7 999 5 [ [ -LRB- cord-005453-4057qib7 999 6 P059 P059 NNP cord-005453-4057qib7 999 7 Image image NN cord-005453-4057qib7 999 8 ] ] -RRB- cord-005453-4057qib7 999 9 1 1 CD cord-005453-4057qib7 999 10 . . . cord-005453-4057qib7 1000 1 Figure figure NN cord-005453-4057qib7 1000 2 1 1 CD cord-005453-4057qib7 1000 3 ] ] -RRB- cord-005453-4057qib7 1000 4 Results result NNS cord-005453-4057qib7 1001 1 : : : cord-005453-4057qib7 1001 2 We -PRON- PRP cord-005453-4057qib7 1001 3 found find VBD cord-005453-4057qib7 1001 4 , , , cord-005453-4057qib7 1002 1 that that IN cord-005453-4057qib7 1002 2 patients patient NNS cord-005453-4057qib7 1002 3 transplanted transplant VBN cord-005453-4057qib7 1002 4 with with IN cord-005453-4057qib7 1002 5 graft graft NN cord-005453-4057qib7 1002 6 NK nk NN cord-005453-4057qib7 1002 7 cell cell NN cord-005453-4057qib7 1002 8 doses dose NNS cord-005453-4057qib7 1002 9 above above IN cord-005453-4057qib7 1002 10 the the DT cord-005453-4057qib7 1002 11 median median NN cord-005453-4057qib7 1002 12 of of IN cord-005453-4057qib7 1002 13 27x10 27x10 CD cord-005453-4057qib7 1002 14 6 6 CD cord-005453-4057qib7 1002 15 /kg /kg NFP cord-005453-4057qib7 1002 16 and and CC cord-005453-4057qib7 1002 17 fractions fraction NNS cord-005453-4057qib7 1002 18 of of IN cord-005453-4057qib7 1002 19 NK NK NNP cord-005453-4057qib7 1002 20 cells cell NNS cord-005453-4057qib7 1002 21 out out IN cord-005453-4057qib7 1002 22 of of IN cord-005453-4057qib7 1002 23 lymphocytes lymphocyte NNS cord-005453-4057qib7 1002 24 above above IN cord-005453-4057qib7 1002 25 the the DT cord-005453-4057qib7 1002 26 median median NN cord-005453-4057qib7 1002 27 of of IN cord-005453-4057qib7 1002 28 8.1 8.1 CD cord-005453-4057qib7 1002 29 % % NN cord-005453-4057qib7 1003 1 had have VBD cord-005453-4057qib7 1003 2 significantly significantly RB cord-005453-4057qib7 1003 3 increased increase VBN cord-005453-4057qib7 1003 4 relapse relapse NN cord-005453-4057qib7 1003 5 - - HYPH cord-005453-4057qib7 1003 6 free free JJ cord-005453-4057qib7 1003 7 - - HYPH cord-005453-4057qib7 1003 8 survival survival NN cord-005453-4057qib7 1003 9 compared compare VBN cord-005453-4057qib7 1003 10 to to IN cord-005453-4057qib7 1003 11 patients patient NNS cord-005453-4057qib7 1003 12 transplanted transplant VBN cord-005453-4057qib7 1003 13 with with IN cord-005453-4057qib7 1003 14 grafts graft NNS cord-005453-4057qib7 1003 15 containing contain VBG cord-005453-4057qib7 1003 16 NK NK NNP cord-005453-4057qib7 1003 17 cell cell NN cord-005453-4057qib7 1003 18 doses dose NNS cord-005453-4057qib7 1003 19 below below IN cord-005453-4057qib7 1003 20 these these DT cord-005453-4057qib7 1003 21 values value NNS cord-005453-4057qib7 1003 22 , , , cord-005453-4057qib7 1003 23 figure figure NN cord-005453-4057qib7 1003 24 1 1 CD cord-005453-4057qib7 1003 25 ; ; : cord-005453-4057qib7 1003 26 results result NNS cord-005453-4057qib7 1003 27 stayed stay VBD cord-005453-4057qib7 1003 28 significant significant JJ cord-005453-4057qib7 1003 29 in in IN cord-005453-4057qib7 1003 30 multivariate multivariate JJ cord-005453-4057qib7 1003 31 analyses analysis NNS cord-005453-4057qib7 1003 32 . . . cord-005453-4057qib7 1004 1 Relapse relapse NN cord-005453-4057qib7 1004 2 incidence incidence NN cord-005453-4057qib7 1004 3 was be VBD cord-005453-4057qib7 1004 4 significantly significantly RB cord-005453-4057qib7 1004 5 lower low JJR cord-005453-4057qib7 1004 6 in in IN cord-005453-4057qib7 1004 7 uni uni JJ cord-005453-4057qib7 1004 8 - - HYPH cord-005453-4057qib7 1004 9 and and CC cord-005453-4057qib7 1004 10 multivariate multivariate JJ cord-005453-4057qib7 1004 11 analyses analysis NNS cord-005453-4057qib7 1004 12 in in IN cord-005453-4057qib7 1004 13 patients patient NNS cord-005453-4057qib7 1004 14 receiving receive VBG cord-005453-4057qib7 1004 15 grafts graft NNS cord-005453-4057qib7 1004 16 with with IN cord-005453-4057qib7 1004 17 high high JJ cord-005453-4057qib7 1004 18 NK NK NNP cord-005453-4057qib7 1004 19 cell cell NN cord-005453-4057qib7 1004 20 fractions fraction NNS cord-005453-4057qib7 1004 21 compared compare VBN cord-005453-4057qib7 1004 22 with with IN cord-005453-4057qib7 1004 23 low low JJ cord-005453-4057qib7 1004 24 fractions fraction NNS cord-005453-4057qib7 1004 25 , , , cord-005453-4057qib7 1004 26 p=0.01 p=0.01 NNP cord-005453-4057qib7 1004 27 , , , cord-005453-4057qib7 1004 28 with with IN cord-005453-4057qib7 1004 29 1-year 1-year CD cord-005453-4057qib7 1004 30 relapse relapse NN cord-005453-4057qib7 1004 31 rates rate NNS cord-005453-4057qib7 1004 32 of of IN cord-005453-4057qib7 1004 33 8 8 CD cord-005453-4057qib7 1004 34 % % NN cord-005453-4057qib7 1004 35 versus versus IN cord-005453-4057qib7 1004 36 27 27 CD cord-005453-4057qib7 1004 37 % % NN cord-005453-4057qib7 1004 38 in in IN cord-005453-4057qib7 1004 39 patients patient NNS cord-005453-4057qib7 1004 40 transplanted transplant VBN cord-005453-4057qib7 1004 41 with with IN cord-005453-4057qib7 1004 42 high high JJ cord-005453-4057qib7 1004 43 versus versus IN cord-005453-4057qib7 1004 44 low low JJ cord-005453-4057qib7 1004 45 fractions fraction NNS cord-005453-4057qib7 1004 46 of of IN cord-005453-4057qib7 1004 47 NK NK NNP cord-005453-4057qib7 1004 48 cells cell NNS cord-005453-4057qib7 1004 49 , , , cord-005453-4057qib7 1004 50 p=0.01 p=0.01 NNP cord-005453-4057qib7 1004 51 . . . cord-005453-4057qib7 1005 1 Peripheral peripheral JJ cord-005453-4057qib7 1005 2 blood blood NN cord-005453-4057qib7 1005 3 concentrations concentration NNS cord-005453-4057qib7 1005 4 of of IN cord-005453-4057qib7 1005 5 NK NK NNP cord-005453-4057qib7 1005 6 cells cell NNS cord-005453-4057qib7 1005 7 obtained obtain VBN cord-005453-4057qib7 1005 8 from from IN cord-005453-4057qib7 1005 9 samples sample NNS cord-005453-4057qib7 1005 10 from from IN cord-005453-4057qib7 1005 11 17 17 CD cord-005453-4057qib7 1005 12 PBSC PBSC NNP cord-005453-4057qib7 1005 13 donors donor NNS cord-005453-4057qib7 1005 14 before before IN cord-005453-4057qib7 1005 15 G G NNP cord-005453-4057qib7 1005 16 - - HYPH cord-005453-4057qib7 1005 17 CSF CSF NNP cord-005453-4057qib7 1005 18 mobilization mobilization NN cord-005453-4057qib7 1005 19 were be VBD cord-005453-4057qib7 1005 20 significantly significantly RB cord-005453-4057qib7 1005 21 correlated correlate VBN cord-005453-4057qib7 1005 22 to to IN cord-005453-4057qib7 1005 23 graft graft NN cord-005453-4057qib7 1005 24 concentrations concentration NNS cord-005453-4057qib7 1005 25 - - : cord-005453-4057qib7 1005 26 and and CC cord-005453-4057qib7 1005 27 fractions fraction NNS cord-005453-4057qib7 1005 28 of of IN cord-005453-4057qib7 1005 29 NK NK NNP cord-005453-4057qib7 1005 30 cells cell NNS cord-005453-4057qib7 1005 31 .. .. . cord-005453-4057qib7 1006 1 Analyses analysis NNS cord-005453-4057qib7 1006 2 of of IN cord-005453-4057qib7 1006 3 graft graft NN cord-005453-4057qib7 1006 4 contents content NNS cord-005453-4057qib7 1006 5 of of IN cord-005453-4057qib7 1006 6 NKT NKT NNP cord-005453-4057qib7 1006 7 cells cell NNS cord-005453-4057qib7 1006 8 showed show VBD cord-005453-4057qib7 1006 9 that that IN cord-005453-4057qib7 1006 10 the the DT cord-005453-4057qib7 1006 11 incidence incidence NN cord-005453-4057qib7 1006 12 of of IN cord-005453-4057qib7 1006 13 grade grade NN cord-005453-4057qib7 1006 14 II II NNP cord-005453-4057qib7 1006 15 - - HYPH cord-005453-4057qib7 1006 16 IV IV NNP cord-005453-4057qib7 1006 17 acute acute JJ cord-005453-4057qib7 1006 18 GVHD GVHD NNP cord-005453-4057qib7 1006 19 were be VBD cord-005453-4057qib7 1006 20 significantly significantly RB cord-005453-4057qib7 1006 21 lower low JJR cord-005453-4057qib7 1006 22 in in IN cord-005453-4057qib7 1006 23 patients patient NNS cord-005453-4057qib7 1007 1 Background background NN cord-005453-4057qib7 1007 2 : : : cord-005453-4057qib7 1007 3 Extracorporeal extracorporeal JJ cord-005453-4057qib7 1007 4 photopheresis photopheresis NN cord-005453-4057qib7 1007 5 ( ( -LRB- cord-005453-4057qib7 1007 6 ECP ECP NNP cord-005453-4057qib7 1007 7 ) ) -RRB- cord-005453-4057qib7 1007 8 is be VBZ cord-005453-4057qib7 1007 9 an an DT cord-005453-4057qib7 1007 10 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 1007 11 treatment treatment NN cord-005453-4057qib7 1007 12 that that WDT cord-005453-4057qib7 1007 13 has have VBZ cord-005453-4057qib7 1007 14 shown show VBN cord-005453-4057qib7 1007 15 efficacy efficacy NN cord-005453-4057qib7 1007 16 in in IN cord-005453-4057qib7 1007 17 steroid steroid NN cord-005453-4057qib7 1007 18 refractory refractory JJ cord-005453-4057qib7 1007 19 acute acute JJ cord-005453-4057qib7 1007 20 GvHD GvHD NNP cord-005453-4057qib7 1007 21 , , , cord-005453-4057qib7 1007 22 but but CC cord-005453-4057qib7 1007 23 the the DT cord-005453-4057qib7 1007 24 mechanism mechanism NN cord-005453-4057qib7 1007 25 of of IN cord-005453-4057qib7 1007 26 action action NN cord-005453-4057qib7 1007 27 is be VBZ cord-005453-4057qib7 1007 28 only only RB cord-005453-4057qib7 1007 29 partially partially RB cord-005453-4057qib7 1007 30 understood understand VBN cord-005453-4057qib7 1007 31 . . . cord-005453-4057qib7 1008 1 There there EX cord-005453-4057qib7 1008 2 is be VBZ cord-005453-4057qib7 1008 3 no no DT cord-005453-4057qib7 1008 4 clear clear JJ cord-005453-4057qib7 1008 5 relationship relationship NN cord-005453-4057qib7 1008 6 between between IN cord-005453-4057qib7 1008 7 the the DT cord-005453-4057qib7 1008 8 ECP ECP NNP cord-005453-4057qib7 1008 9 - - HYPH cord-005453-4057qib7 1008 10 treated treat VBN cord-005453-4057qib7 1008 11 mononuclear mononuclear JJ cord-005453-4057qib7 1008 12 cells cell NNS cord-005453-4057qib7 1008 13 ( ( -LRB- cord-005453-4057qib7 1008 14 MNC MNC NNP cord-005453-4057qib7 1008 15 ) ) -RRB- cord-005453-4057qib7 1008 16 or or CC cord-005453-4057qib7 1008 17 lymphocyte lymphocyte NN cord-005453-4057qib7 1008 18 numbers number NNS cord-005453-4057qib7 1008 19 and and CC cord-005453-4057qib7 1008 20 response response NN cord-005453-4057qib7 1008 21 to to IN cord-005453-4057qib7 1008 22 ECP ECP NNP cord-005453-4057qib7 1008 23 . . . cord-005453-4057qib7 1009 1 The the DT cord-005453-4057qib7 1009 2 objective objective NN cord-005453-4057qib7 1009 3 of of IN cord-005453-4057qib7 1009 4 the the DT cord-005453-4057qib7 1009 5 study study NN cord-005453-4057qib7 1009 6 was be VBD cord-005453-4057qib7 1009 7 to to TO cord-005453-4057qib7 1009 8 analyse analyse VB cord-005453-4057qib7 1009 9 the the DT cord-005453-4057qib7 1009 10 relationship relationship NN cord-005453-4057qib7 1009 11 between between IN cord-005453-4057qib7 1009 12 the the DT cord-005453-4057qib7 1009 13 infused infuse VBN cord-005453-4057qib7 1009 14 subpopulation subpopulation NN cord-005453-4057qib7 1009 15 cellularity cellularity NN cord-005453-4057qib7 1009 16 and and CC cord-005453-4057qib7 1009 17 response response NN cord-005453-4057qib7 1009 18 . . . cord-005453-4057qib7 1010 1 Methods method NNS cord-005453-4057qib7 1010 2 : : : cord-005453-4057qib7 1010 3 65 65 CD cord-005453-4057qib7 1010 4 patients patient NNS cord-005453-4057qib7 1010 5 from from IN cord-005453-4057qib7 1010 6 7 7 CD cord-005453-4057qib7 1010 7 different different JJ cord-005453-4057qib7 1010 8 centers center NNS cord-005453-4057qib7 1010 9 with with IN cord-005453-4057qib7 1010 10 a a DT cord-005453-4057qib7 1010 11 total total NN cord-005453-4057qib7 1010 12 of of IN cord-005453-4057qib7 1010 13 1008 1008 CD cord-005453-4057qib7 1010 14 ECP ECP NNP cord-005453-4057qib7 1010 15 procedures procedure NNS cord-005453-4057qib7 1010 16 were be VBD cord-005453-4057qib7 1010 17 retrospectively retrospectively RB cord-005453-4057qib7 1010 18 analized analize VBN cord-005453-4057qib7 1010 19 . . . cord-005453-4057qib7 1011 1 ECP ECP NNP cord-005453-4057qib7 1011 2 procedures procedure NNS cord-005453-4057qib7 1011 3 were be VBD cord-005453-4057qib7 1011 4 performed perform VBN cord-005453-4057qib7 1011 5 from from IN cord-005453-4057qib7 1011 6 January-2011 January-2011 NNP cord-005453-4057qib7 1011 7 to to IN cord-005453-4057qib7 1011 8 June-2017 june-2017 ADD cord-005453-4057qib7 1011 9 . . . cord-005453-4057qib7 1012 1 All all DT cord-005453-4057qib7 1012 2 ECP ECP NNP cord-005453-4057qib7 1012 3 procedures procedure NNS cord-005453-4057qib7 1012 4 were be VBD cord-005453-4057qib7 1012 5 performed perform VBN cord-005453-4057qib7 1012 6 with with IN cord-005453-4057qib7 1012 7 the the DT cord-005453-4057qib7 1012 8 off off JJ cord-005453-4057qib7 1012 9 - - HYPH cord-005453-4057qib7 1012 10 line line NN cord-005453-4057qib7 1012 11 system system NN cord-005453-4057qib7 1012 12 . . . cord-005453-4057qib7 1013 1 The the DT cord-005453-4057qib7 1013 2 response response NN cord-005453-4057qib7 1013 3 was be VBD cord-005453-4057qib7 1013 4 defined define VBN cord-005453-4057qib7 1013 5 as as IN cord-005453-4057qib7 1013 6 Responder Responder NNP cord-005453-4057qib7 1013 7 ( ( -LRB- cord-005453-4057qib7 1013 8 Complete complete JJ cord-005453-4057qib7 1013 9 and and CC cord-005453-4057qib7 1013 10 Partial Partial NNP cord-005453-4057qib7 1013 11 Response Response NNP cord-005453-4057qib7 1013 12 ) ) -RRB- cord-005453-4057qib7 1013 13 and and CC cord-005453-4057qib7 1013 14 Non Non NNP cord-005453-4057qib7 1013 15 - - NN cord-005453-4057qib7 1013 16 responder responder NN cord-005453-4057qib7 1013 17 . . . cord-005453-4057qib7 1014 1 Infused infuse VBN cord-005453-4057qib7 1014 2 cell cell NN cord-005453-4057qib7 1014 3 numbers number NNS cord-005453-4057qib7 1014 4 for for IN cord-005453-4057qib7 1014 5 lymphocytes lymphocyte NNS cord-005453-4057qib7 1014 6 , , , cord-005453-4057qib7 1014 7 monocytes monocyte NNS cord-005453-4057qib7 1014 8 and and CC cord-005453-4057qib7 1014 9 mononuclear mononuclear NN cord-005453-4057qib7 1014 10 cells cell NNS cord-005453-4057qib7 1014 11 ( ( -LRB- cord-005453-4057qib7 1014 12 Lym+Mon Lym+Mon NNP cord-005453-4057qib7 1014 13 , , , cord-005453-4057qib7 1014 14 MNC MNC NNP cord-005453-4057qib7 1014 15 ) ) -RRB- cord-005453-4057qib7 1014 16 were be VBD cord-005453-4057qib7 1014 17 calculated calculate VBN cord-005453-4057qib7 1014 18 . . . cord-005453-4057qib7 1015 1 For for IN cord-005453-4057qib7 1015 2 analytic analytic JJ cord-005453-4057qib7 1015 3 purposes purpose NNS cord-005453-4057qib7 1015 4 , , , cord-005453-4057qib7 1015 5 the the DT cord-005453-4057qib7 1015 6 median median JJ cord-005453-4057qib7 1015 7 number number NN cord-005453-4057qib7 1015 8 of of IN cord-005453-4057qib7 1015 9 cells cell NNS cord-005453-4057qib7 1015 10 infused infuse VBN cord-005453-4057qib7 1015 11 per per IN cord-005453-4057qib7 1015 12 procedure procedure NN cord-005453-4057qib7 1015 13 until until IN cord-005453-4057qib7 1015 14 response response NN cord-005453-4057qib7 1015 15 ( ( -LRB- cord-005453-4057qib7 1015 16 or or CC cord-005453-4057qib7 1015 17 until until IN cord-005453-4057qib7 1015 18 the the DT cord-005453-4057qib7 1015 19 median median JJ cord-005453-4057qib7 1015 20 number number NN cord-005453-4057qib7 1015 21 of of IN cord-005453-4057qib7 1015 22 procedures procedure NNS cord-005453-4057qib7 1015 23 until until IN cord-005453-4057qib7 1015 24 response response NN cord-005453-4057qib7 1015 25 for for IN cord-005453-4057qib7 1015 26 non non JJ cord-005453-4057qib7 1015 27 - - JJ cord-005453-4057qib7 1015 28 responding respond VBG cord-005453-4057qib7 1015 29 patients patient NNS cord-005453-4057qib7 1015 30 ) ) -RRB- cord-005453-4057qib7 1015 31 and and CC cord-005453-4057qib7 1015 32 the the DT cord-005453-4057qib7 1015 33 cumulative cumulative JJ cord-005453-4057qib7 1015 34 number number NN cord-005453-4057qib7 1015 35 of of IN cord-005453-4057qib7 1015 36 cells cell NNS cord-005453-4057qib7 1015 37 infused infuse VBN cord-005453-4057qib7 1015 38 until until IN cord-005453-4057qib7 1015 39 response response NN cord-005453-4057qib7 1015 40 ( ( -LRB- cord-005453-4057qib7 1015 41 or or CC cord-005453-4057qib7 1015 42 until until IN cord-005453-4057qib7 1015 43 the the DT cord-005453-4057qib7 1015 44 median median NN cord-005453-4057qib7 1015 45 in in IN cord-005453-4057qib7 1015 46 non non NNS cord-005453-4057qib7 1015 47 - - NNS cord-005453-4057qib7 1015 48 responders responder NNS cord-005453-4057qib7 1015 49 ) ) -RRB- cord-005453-4057qib7 1015 50 were be VBD cord-005453-4057qib7 1015 51 calculated calculate VBN cord-005453-4057qib7 1015 52 for for IN cord-005453-4057qib7 1015 53 all all PDT cord-005453-4057qib7 1015 54 the the DT cord-005453-4057qib7 1015 55 subgroups subgroup NNS cord-005453-4057qib7 1015 56 . . . cord-005453-4057qib7 1016 1 Same same JJ cord-005453-4057qib7 1016 2 procedures procedure NNS cord-005453-4057qib7 1016 3 were be VBD cord-005453-4057qib7 1016 4 performed perform VBN cord-005453-4057qib7 1016 5 with with IN cord-005453-4057qib7 1016 6 the the DT cord-005453-4057qib7 1016 7 number number NN cord-005453-4057qib7 1016 8 cells cell NNS cord-005453-4057qib7 1016 9 infused infuse VBN cord-005453-4057qib7 1016 10 until until IN cord-005453-4057qib7 1016 11 day day NN cord-005453-4057qib7 1016 12 30 30 CD cord-005453-4057qib7 1016 13 of of IN cord-005453-4057qib7 1016 14 ECP ECP NNP cord-005453-4057qib7 1016 15 . . . cord-005453-4057qib7 1017 1 Finally finally RB cord-005453-4057qib7 1017 2 , , , cord-005453-4057qib7 1017 3 the the DT cord-005453-4057qib7 1017 4 response response NN cord-005453-4057qib7 1017 5 and and CC cord-005453-4057qib7 1017 6 survival survival NN cord-005453-4057qib7 1017 7 impact impact NN cord-005453-4057qib7 1017 8 of of IN cord-005453-4057qib7 1017 9 infusing infuse VBG cord-005453-4057qib7 1017 10 a a DT cord-005453-4057qib7 1017 11 number number NN cord-005453-4057qib7 1017 12 of of IN cord-005453-4057qib7 1017 13 cells cell NNS cord-005453-4057qib7 1017 14 above above IN cord-005453-4057qib7 1017 15 or or CC cord-005453-4057qib7 1017 16 below below IN cord-005453-4057qib7 1017 17 the the DT cord-005453-4057qib7 1017 18 median median NN cord-005453-4057qib7 1017 19 and and CC cord-005453-4057qib7 1017 20 in in IN cord-005453-4057qib7 1017 21 different different JJ cord-005453-4057qib7 1017 22 tertiles tertile NNS cord-005453-4057qib7 1017 23 was be VBD cord-005453-4057qib7 1017 24 assessed assess VBN cord-005453-4057qib7 1017 25 until until IN cord-005453-4057qib7 1017 26 the the DT cord-005453-4057qib7 1017 27 median median JJ cord-005453-4057qib7 1017 28 number number NN cord-005453-4057qib7 1017 29 of of IN cord-005453-4057qib7 1017 30 procedures procedure NNS cord-005453-4057qib7 1017 31 needed need VBN cord-005453-4057qib7 1017 32 to to TO cord-005453-4057qib7 1017 33 achieve achieve VB cord-005453-4057qib7 1017 34 a a DT cord-005453-4057qib7 1017 35 response response NN cord-005453-4057qib7 1017 36 . . . cord-005453-4057qib7 1018 1 [ [ -LRB- cord-005453-4057qib7 1018 2 [ [ -LRB- cord-005453-4057qib7 1018 3 P060 P060 NNP cord-005453-4057qib7 1018 4 Image Image NNP cord-005453-4057qib7 1018 5 ] ] -RRB- cord-005453-4057qib7 1018 6 1 1 CD cord-005453-4057qib7 1018 7 . . . cord-005453-4057qib7 1019 1 Results result NNS cord-005453-4057qib7 1019 2 : : : cord-005453-4057qib7 1020 1 The the DT cord-005453-4057qib7 1020 2 median median JJ cord-005453-4057qib7 1020 3 number number NN cord-005453-4057qib7 1020 4 of of IN cord-005453-4057qib7 1020 5 procedures procedure NNS cord-005453-4057qib7 1020 6 until until IN cord-005453-4057qib7 1020 7 response response NN cord-005453-4057qib7 1020 8 was be VBD cord-005453-4057qib7 1020 9 3 3 CD cord-005453-4057qib7 1020 10 . . . cord-005453-4057qib7 1021 1 We -PRON- PRP cord-005453-4057qib7 1021 2 observed observe VBD cord-005453-4057qib7 1021 3 a a DT cord-005453-4057qib7 1021 4 trend trend NN cord-005453-4057qib7 1021 5 towards towards IN cord-005453-4057qib7 1021 6 a a DT cord-005453-4057qib7 1021 7 higher high JJR cord-005453-4057qib7 1021 8 median median JJ cord-005453-4057qib7 1021 9 number number NN cord-005453-4057qib7 1021 10 of of IN cord-005453-4057qib7 1021 11 monocytes monocyte NNS cord-005453-4057qib7 1021 12 per per IN cord-005453-4057qib7 1021 13 procedure procedure NN cord-005453-4057qib7 1021 14 and and CC cord-005453-4057qib7 1021 15 cumulative cumulative JJ cord-005453-4057qib7 1021 16 infused infuse VBN cord-005453-4057qib7 1021 17 monocytes monocyte NNS cord-005453-4057qib7 1021 18 in in IN cord-005453-4057qib7 1021 19 responding respond VBG cord-005453-4057qib7 1021 20 patients patient NNS cord-005453-4057qib7 1021 21 ( ( -LRB- cord-005453-4057qib7 1021 22 median median JJ cord-005453-4057qib7 1021 23 number number NN cord-005453-4057qib7 1021 24 infused infuse VBN cord-005453-4057qib7 1021 25 19.0 19.0 CD cord-005453-4057qib7 1021 26 vs vs IN cord-005453-4057qib7 1021 27 13.5 13.5 CD cord-005453-4057qib7 1021 28 x10 x10 CD cord-005453-4057qib7 1021 29 6 6 CD cord-005453-4057qib7 1021 30 /kg /kg . cord-005453-4057qib7 1022 1 p=0.071 p=0.071 NNP cord-005453-4057qib7 1022 2 , , , cord-005453-4057qib7 1022 3 cumulative cumulative JJ cord-005453-4057qib7 1022 4 infused infuse VBN cord-005453-4057qib7 1022 5 median median JJ cord-005453-4057qib7 1022 6 number number NN cord-005453-4057qib7 1022 7 71.5 71.5 CD cord-005453-4057qib7 1022 8 vs vs IN cord-005453-4057qib7 1022 9 41 41 CD cord-005453-4057qib7 1022 10 x10 x10 CD cord-005453-4057qib7 1022 11 6 6 CD cord-005453-4057qib7 1022 12 /kg /kg . cord-005453-4057qib7 1022 13 p=0.067 p=0.067 NNP cord-005453-4057qib7 1022 14 ) ) -RRB- cord-005453-4057qib7 1022 15 that that WDT cord-005453-4057qib7 1022 16 was be VBD cord-005453-4057qib7 1022 17 lost lose VBN cord-005453-4057qib7 1022 18 in in IN cord-005453-4057qib7 1022 19 the the DT cord-005453-4057qib7 1022 20 day day NN cord-005453-4057qib7 1022 21 30 30 CD cord-005453-4057qib7 1022 22 of of IN cord-005453-4057qib7 1022 23 treatment treatment NN cord-005453-4057qib7 1022 24 . . . cord-005453-4057qib7 1023 1 There there EX cord-005453-4057qib7 1023 2 was be VBD cord-005453-4057qib7 1023 3 also also RB cord-005453-4057qib7 1023 4 a a DT cord-005453-4057qib7 1023 5 trend trend NN cord-005453-4057qib7 1023 6 toward toward IN cord-005453-4057qib7 1023 7 higher high JJR cord-005453-4057qib7 1023 8 median median NN cord-005453-4057qib7 1023 9 infused infuse VBN cord-005453-4057qib7 1023 10 MNC MNC NNP cord-005453-4057qib7 1023 11 until until IN cord-005453-4057qib7 1023 12 response response NN cord-005453-4057qib7 1023 13 for for IN cord-005453-4057qib7 1023 14 responders responder NNS cord-005453-4057qib7 1023 15 ( ( -LRB- cord-005453-4057qib7 1023 16 54 54 CD cord-005453-4057qib7 1023 17 vs vs IN cord-005453-4057qib7 1023 18 37 37 CD cord-005453-4057qib7 1023 19 x10 x10 CD cord-005453-4057qib7 1023 20 6 6 CD cord-005453-4057qib7 1023 21 /kg /kg . cord-005453-4057qib7 1023 22 p=0.087 p=0.087 NNP cord-005453-4057qib7 1023 23 ) ) -RRB- cord-005453-4057qib7 1023 24 . . . cord-005453-4057qib7 1024 1 We -PRON- PRP cord-005453-4057qib7 1024 2 observed observe VBD cord-005453-4057qib7 1024 3 no no DT cord-005453-4057qib7 1024 4 differences difference NNS cord-005453-4057qib7 1024 5 in in IN cord-005453-4057qib7 1024 6 the the DT cord-005453-4057qib7 1024 7 number number NN cord-005453-4057qib7 1024 8 of of IN cord-005453-4057qib7 1024 9 lymphocytes lymphocyte NNS cord-005453-4057qib7 1024 10 infused infuse VBN cord-005453-4057qib7 1024 11 , , , cord-005453-4057qib7 1024 12 but but CC cord-005453-4057qib7 1024 13 patients patient NNS cord-005453-4057qib7 1024 14 who who WP cord-005453-4057qib7 1024 15 received receive VBD cord-005453-4057qib7 1024 16 a a DT cord-005453-4057qib7 1024 17 number number NN cord-005453-4057qib7 1024 18 of of IN cord-005453-4057qib7 1024 19 lymphocytes lymphocyte NNS cord-005453-4057qib7 1024 20 per per IN cord-005453-4057qib7 1024 21 procedure procedure NN cord-005453-4057qib7 1024 22 over over IN cord-005453-4057qib7 1024 23 the the DT cord-005453-4057qib7 1024 24 first first JJ cord-005453-4057qib7 1024 25 tertile tertile NNP cord-005453-4057qib7 1024 26 ( ( -LRB- cord-005453-4057qib7 1024 27 31 31 CD cord-005453-4057qib7 1024 28 x10 x10 CD cord-005453-4057qib7 1024 29 6 6 CD cord-005453-4057qib7 1024 30 /kg /kg NFP cord-005453-4057qib7 1024 31 ) ) -RRB- cord-005453-4057qib7 1024 32 presented present VBD cord-005453-4057qib7 1024 33 higher high JJR cord-005453-4057qib7 1024 34 response response NN cord-005453-4057qib7 1024 35 rates rate NNS cord-005453-4057qib7 1024 36 ( ( -LRB- cord-005453-4057qib7 1024 37 75 75 CD cord-005453-4057qib7 1024 38 % % NN cord-005453-4057qib7 1024 39 vs vs IN cord-005453-4057qib7 1024 40 45 45 CD cord-005453-4057qib7 1024 41 % % NN cord-005453-4057qib7 1024 42 , , , cord-005453-4057qib7 1024 43 p=0.0317 p=0.0317 NNP cord-005453-4057qib7 1024 44 ) ) -RRB- cord-005453-4057qib7 1024 45 . . . cord-005453-4057qib7 1025 1 None none NN cord-005453-4057qib7 1025 2 of of IN cord-005453-4057qib7 1025 3 the the DT cord-005453-4057qib7 1025 4 other other JJ cord-005453-4057qib7 1025 5 analysed analyse VBN cord-005453-4057qib7 1025 6 parameters parameter NNS cord-005453-4057qib7 1025 7 showed show VBD cord-005453-4057qib7 1025 8 a a DT cord-005453-4057qib7 1025 9 significant significant JJ cord-005453-4057qib7 1025 10 impact impact NN cord-005453-4057qib7 1025 11 in in IN cord-005453-4057qib7 1025 12 overall overall JJ cord-005453-4057qib7 1025 13 survival survival NN cord-005453-4057qib7 1025 14 . . . cord-005453-4057qib7 1026 1 Conclusions conclusion NNS cord-005453-4057qib7 1026 2 : : : cord-005453-4057qib7 1027 1 Patients patient NNS cord-005453-4057qib7 1027 2 with with IN cord-005453-4057qib7 1027 3 acute acute JJ cord-005453-4057qib7 1027 4 GvHD GvHD NNP cord-005453-4057qib7 1027 5 who who WP cord-005453-4057qib7 1027 6 responded respond VBD cord-005453-4057qib7 1027 7 to to IN cord-005453-4057qib7 1027 8 ECP ECP NNP cord-005453-4057qib7 1027 9 received receive VBD cord-005453-4057qib7 1027 10 higher high JJR cord-005453-4057qib7 1027 11 numbers number NNS cord-005453-4057qib7 1027 12 of of IN cord-005453-4057qib7 1027 13 monocytes monocyte NNS cord-005453-4057qib7 1027 14 and and CC cord-005453-4057qib7 1027 15 MNC MNC NNP cord-005453-4057qib7 1027 16 in in IN cord-005453-4057qib7 1027 17 the the DT cord-005453-4057qib7 1027 18 early early JJ cord-005453-4057qib7 1027 19 phase phase NN cord-005453-4057qib7 1027 20 of of IN cord-005453-4057qib7 1027 21 the the DT cord-005453-4057qib7 1027 22 treatment treatment NN cord-005453-4057qib7 1027 23 ( ( -LRB- cord-005453-4057qib7 1027 24 a a DT cord-005453-4057qib7 1027 25 median median NN cord-005453-4057qib7 1027 26 of of IN cord-005453-4057qib7 1027 27 the the DT cord-005453-4057qib7 1027 28 first first JJ cord-005453-4057qib7 1027 29 3 3 CD cord-005453-4057qib7 1027 30 processes process NNS cord-005453-4057qib7 1027 31 ) ) -RRB- cord-005453-4057qib7 1027 32 . . . cord-005453-4057qib7 1028 1 Also also RB cord-005453-4057qib7 1028 2 the the DT cord-005453-4057qib7 1028 3 patients patient NNS cord-005453-4057qib7 1028 4 who who WP cord-005453-4057qib7 1028 5 received receive VBD cord-005453-4057qib7 1028 6 higher high JJR cord-005453-4057qib7 1028 7 numbers number NNS cord-005453-4057qib7 1028 8 of of IN cord-005453-4057qib7 1028 9 lymphocytes lymphocyte NNS cord-005453-4057qib7 1028 10 in in IN cord-005453-4057qib7 1028 11 the the DT cord-005453-4057qib7 1028 12 first first JJ cord-005453-4057qib7 1028 13 procedures procedure NNS cord-005453-4057qib7 1028 14 achieved achieve VBD cord-005453-4057qib7 1028 15 a a DT cord-005453-4057qib7 1028 16 higher high JJR cord-005453-4057qib7 1028 17 response response NN cord-005453-4057qib7 1028 18 rate rate NN cord-005453-4057qib7 1028 19 . . . cord-005453-4057qib7 1029 1 These these DT cord-005453-4057qib7 1029 2 findings finding NNS cord-005453-4057qib7 1029 3 suggest suggest VBP cord-005453-4057qib7 1029 4 the the DT cord-005453-4057qib7 1029 5 possibility possibility NN cord-005453-4057qib7 1029 6 that that IN cord-005453-4057qib7 1029 7 higher high JJR cord-005453-4057qib7 1029 8 number number NN cord-005453-4057qib7 1029 9 of of IN cord-005453-4057qib7 1029 10 treated treat VBN cord-005453-4057qib7 1029 11 and and CC cord-005453-4057qib7 1029 12 infused infuse VBN cord-005453-4057qib7 1029 13 cells cell NNS cord-005453-4057qib7 1029 14 could could MD cord-005453-4057qib7 1029 15 influence influence VB cord-005453-4057qib7 1029 16 the the DT cord-005453-4057qib7 1029 17 response response NN cord-005453-4057qib7 1029 18 to to IN cord-005453-4057qib7 1029 19 ECP ECP NNP cord-005453-4057qib7 1029 20 , , , cord-005453-4057qib7 1029 21 but but CC cord-005453-4057qib7 1029 22 specifically specifically RB cord-005453-4057qib7 1029 23 designed design VBN cord-005453-4057qib7 1029 24 prospective prospective JJ cord-005453-4057qib7 1029 25 studies study NNS cord-005453-4057qib7 1029 26 are be VBP cord-005453-4057qib7 1029 27 need nee VBN cord-005453-4057qib7 1029 28 to to IN cord-005453-4057qib7 1029 29 asses ass NNS cord-005453-4057qib7 1029 30 this this DT cord-005453-4057qib7 1029 31 possibility possibility NN cord-005453-4057qib7 1029 32 . . . cord-005453-4057qib7 1030 1 Disclosure disclosure NN cord-005453-4057qib7 1030 2 : : : cord-005453-4057qib7 1030 3 Nothing nothing NN cord-005453-4057qib7 1030 4 to to TO cord-005453-4057qib7 1030 5 declare declare VB cord-005453-4057qib7 1030 6 Background background NN cord-005453-4057qib7 1030 7 : : : cord-005453-4057qib7 1031 1 The the DT cord-005453-4057qib7 1031 2 field field NN cord-005453-4057qib7 1031 3 of of IN cord-005453-4057qib7 1031 4 kidney kidney NN cord-005453-4057qib7 1031 5 transplantation transplantation NN cord-005453-4057qib7 1031 6 has have VBZ cord-005453-4057qib7 1031 7 made make VBN cord-005453-4057qib7 1031 8 enormous enormous JJ cord-005453-4057qib7 1031 9 progress progress NN cord-005453-4057qib7 1031 10 over over IN cord-005453-4057qib7 1031 11 the the DT cord-005453-4057qib7 1031 12 last last JJ cord-005453-4057qib7 1031 13 decades decade NNS cord-005453-4057qib7 1031 14 towards towards IN cord-005453-4057qib7 1031 15 being be VBG cord-005453-4057qib7 1031 16 a a DT cord-005453-4057qib7 1031 17 standard standard JJ cord-005453-4057qib7 1031 18 treatment treatment NN cord-005453-4057qib7 1031 19 for for IN cord-005453-4057qib7 1031 20 patients patient NNS cord-005453-4057qib7 1031 21 with with IN cord-005453-4057qib7 1031 22 end end NN cord-005453-4057qib7 1031 23 - - HYPH cord-005453-4057qib7 1031 24 stage stage NN cord-005453-4057qib7 1031 25 renal renal JJ cord-005453-4057qib7 1031 26 disease disease NN cord-005453-4057qib7 1031 27 . . . cord-005453-4057qib7 1032 1 However however RB cord-005453-4057qib7 1032 2 , , , cord-005453-4057qib7 1032 3 administration administration NN cord-005453-4057qib7 1032 4 of of IN cord-005453-4057qib7 1032 5 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 1032 6 drugs drug NNS cord-005453-4057qib7 1032 7 is be VBZ cord-005453-4057qib7 1032 8 still still RB cord-005453-4057qib7 1032 9 one one CD cord-005453-4057qib7 1032 10 of of IN cord-005453-4057qib7 1032 11 the the DT cord-005453-4057qib7 1032 12 major major JJ cord-005453-4057qib7 1032 13 limitations limitation NNS cord-005453-4057qib7 1032 14 of of IN cord-005453-4057qib7 1032 15 long long JJ cord-005453-4057qib7 1032 16 - - HYPH cord-005453-4057qib7 1032 17 term term NN cord-005453-4057qib7 1032 18 allograft allograft NN cord-005453-4057qib7 1032 19 survival survival NN cord-005453-4057qib7 1032 20 . . . cord-005453-4057qib7 1033 1 Therefore therefore RB cord-005453-4057qib7 1033 2 , , , cord-005453-4057qib7 1033 3 strategies strategy NNS cord-005453-4057qib7 1033 4 for for IN cord-005453-4057qib7 1033 5 induction induction NN cord-005453-4057qib7 1033 6 of of IN cord-005453-4057qib7 1033 7 donorspecific donorspecific NNP cord-005453-4057qib7 1033 8 tolerance tolerance NN cord-005453-4057qib7 1033 9 are be VBP cord-005453-4057qib7 1033 10 highly highly RB cord-005453-4057qib7 1033 11 desirable desirable JJ cord-005453-4057qib7 1033 12 . . . cord-005453-4057qib7 1034 1 To to IN cord-005453-4057qib7 1034 2 this this DT cord-005453-4057qib7 1034 3 aim aim NN cord-005453-4057qib7 1034 4 , , , cord-005453-4057qib7 1034 5 a a DT cord-005453-4057qib7 1034 6 clinical clinical JJ cord-005453-4057qib7 1034 7 phase phase NN cord-005453-4057qib7 1034 8 I -PRON- PRP cord-005453-4057qib7 1034 9 study study VBP cord-005453-4057qib7 1034 10 with with IN cord-005453-4057qib7 1034 11 donor donor NN cord-005453-4057qib7 1034 12 - - HYPH cord-005453-4057qib7 1034 13 derived derive VBN cord-005453-4057qib7 1034 14 modulated modulate VBN cord-005453-4057qib7 1034 15 immune immune JJ cord-005453-4057qib7 1034 16 cells cell NNS cord-005453-4057qib7 1034 17 ( ( -LRB- cord-005453-4057qib7 1034 18 MICs mic NNS cord-005453-4057qib7 1034 19 ) ) -RRB- cord-005453-4057qib7 1034 20 was be VBD cord-005453-4057qib7 1034 21 conducted conduct VBN cord-005453-4057qib7 1034 22 . . . cord-005453-4057qib7 1035 1 Methods method NNS cord-005453-4057qib7 1035 2 : : : cord-005453-4057qib7 1036 1 Donor donor NN cord-005453-4057qib7 1036 2 - - HYPH cord-005453-4057qib7 1036 3 derived derive VBN cord-005453-4057qib7 1036 4 MICs mic NNS cord-005453-4057qib7 1036 5 were be VBD cord-005453-4057qib7 1036 6 manufactured manufacture VBN cord-005453-4057qib7 1036 7 under under IN cord-005453-4057qib7 1036 8 GMP GMP NNP cord-005453-4057qib7 1036 9 conditions condition NNS cord-005453-4057qib7 1036 10 . . . cord-005453-4057qib7 1037 1 Potency potency NN cord-005453-4057qib7 1037 2 of of IN cord-005453-4057qib7 1037 3 MICs mic NNS cord-005453-4057qib7 1037 4 was be VBD cord-005453-4057qib7 1037 5 tested test VBN cord-005453-4057qib7 1037 6 by by IN cord-005453-4057qib7 1037 7 different different JJ cord-005453-4057qib7 1037 8 in in IN cord-005453-4057qib7 1037 9 vitro vitro FW cord-005453-4057qib7 1037 10 bio bio NN cord-005453-4057qib7 1037 11 - - HYPH cord-005453-4057qib7 1037 12 assays assay NNS cord-005453-4057qib7 1037 13 . . . cord-005453-4057qib7 1038 1 MICs mic NNS cord-005453-4057qib7 1038 2 were be VBD cord-005453-4057qib7 1038 3 administered administer VBN cord-005453-4057qib7 1038 4 to to IN cord-005453-4057qib7 1038 5 patients patient NNS cord-005453-4057qib7 1038 6 with with IN cord-005453-4057qib7 1038 7 an an DT cord-005453-4057qib7 1038 8 escalation escalation NN cord-005453-4057qib7 1038 9 from from IN cord-005453-4057qib7 1038 10 1.5 1.5 CD cord-005453-4057qib7 1038 11 x x SYM cord-005453-4057qib7 1038 12 10 10 CD cord-005453-4057qib7 1038 13 6 6 CD cord-005453-4057qib7 1038 14 MICs mic NNS cord-005453-4057qib7 1038 15 / / SYM cord-005453-4057qib7 1038 16 kg kg NNS cord-005453-4057qib7 1038 17 on on IN cord-005453-4057qib7 1038 18 day day NN cord-005453-4057qib7 1038 19 -2 -2 CD cord-005453-4057qib7 1039 1 ( ( -LRB- cord-005453-4057qib7 1039 2 N=3 N=3 NNP cord-005453-4057qib7 1039 3 , , , cord-005453-4057qib7 1039 4 group group NN cord-005453-4057qib7 1039 5 A A NNP cord-005453-4057qib7 1039 6 ) ) -RRB- cord-005453-4057qib7 1039 7 , , , cord-005453-4057qib7 1039 8 to to IN cord-005453-4057qib7 1039 9 1.5 1.5 CD cord-005453-4057qib7 1039 10 x x SYM cord-005453-4057qib7 1039 11 10 10 CD cord-005453-4057qib7 1039 12 8 8 CD cord-005453-4057qib7 1039 13 MICs mic NNS cord-005453-4057qib7 1039 14 / / SYM cord-005453-4057qib7 1039 15 kg kg NNS cord-005453-4057qib7 1039 16 on on IN cord-005453-4057qib7 1039 17 day day NN cord-005453-4057qib7 1039 18 -2 -2 CD cord-005453-4057qib7 1039 19 ( ( -LRB- cord-005453-4057qib7 1039 20 N=3 n=3 NN cord-005453-4057qib7 1039 21 , , , cord-005453-4057qib7 1039 22 group group NN cord-005453-4057qib7 1039 23 B B NNP cord-005453-4057qib7 1039 24 ) ) -RRB- cord-005453-4057qib7 1039 25 or or CC cord-005453-4057qib7 1039 26 on on IN cord-005453-4057qib7 1039 27 day day NN cord-005453-4057qib7 1039 28 -7 -7 . cord-005453-4057qib7 1040 1 ( ( -LRB- cord-005453-4057qib7 1040 2 N=4 N=4 NNP cord-005453-4057qib7 1040 3 , , , cord-005453-4057qib7 1040 4 group group NN cord-005453-4057qib7 1040 5 C C NNP cord-005453-4057qib7 1040 6 ) ) -RRB- cord-005453-4057qib7 1040 7 before before IN cord-005453-4057qib7 1040 8 kidney kidney NN cord-005453-4057qib7 1040 9 transplantation transplantation NN cord-005453-4057qib7 1040 10 accompanied accompany VBN cord-005453-4057qib7 1040 11 by by IN cord-005453-4057qib7 1040 12 standard standard JJ cord-005453-4057qib7 1040 13 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 1040 14 medication medication NN cord-005453-4057qib7 1040 15 post post NN cord-005453-4057qib7 1040 16 - - NN cord-005453-4057qib7 1040 17 transplantation transplantation NN cord-005453-4057qib7 1040 18 . . . cord-005453-4057qib7 1041 1 Frequency frequency NN cord-005453-4057qib7 1041 2 of of IN cord-005453-4057qib7 1041 3 adverse adverse JJ cord-005453-4057qib7 1041 4 events event NNS cord-005453-4057qib7 1041 5 ( ( -LRB- cord-005453-4057qib7 1041 6 AE AE NNP cord-005453-4057qib7 1041 7 ) ) -RRB- cord-005453-4057qib7 1041 8 was be VBD cord-005453-4057qib7 1041 9 assessed assess VBN cord-005453-4057qib7 1041 10 from from IN cord-005453-4057qib7 1041 11 day day NN cord-005453-4057qib7 1041 12 30 30 CD cord-005453-4057qib7 1041 13 until until IN cord-005453-4057qib7 1041 14 day day NN cord-005453-4057qib7 1041 15 360 360 CD cord-005453-4057qib7 1041 16 post post NN cord-005453-4057qib7 1041 17 - - NN cord-005453-4057qib7 1041 18 transplant transplant NN cord-005453-4057qib7 1041 19 . . . cord-005453-4057qib7 1042 1 Dynamic dynamic JJ cord-005453-4057qib7 1042 2 changes change NNS cord-005453-4057qib7 1042 3 of of IN cord-005453-4057qib7 1042 4 various various JJ cord-005453-4057qib7 1042 5 lymphocyte lymphocyte NN cord-005453-4057qib7 1042 6 subsets subset NNS cord-005453-4057qib7 1042 7 in in IN cord-005453-4057qib7 1042 8 patients patient NNS cord-005453-4057qib7 1042 9 after after IN cord-005453-4057qib7 1042 10 MIC mic NN cord-005453-4057qib7 1042 11 therapy therapy NN cord-005453-4057qib7 1042 12 were be VBD cord-005453-4057qib7 1042 13 detected detect VBN cord-005453-4057qib7 1042 14 by by IN cord-005453-4057qib7 1042 15 multicolor multicolor JJ cord-005453-4057qib7 1042 16 flow flow NN cord-005453-4057qib7 1042 17 cytometry cytometry NN cord-005453-4057qib7 1042 18 . . . cord-005453-4057qib7 1043 1 Donor donor NN cord-005453-4057qib7 1043 2 - - HYPH cord-005453-4057qib7 1043 3 specific specific JJ cord-005453-4057qib7 1043 4 immunosuppression immunosuppression NN cord-005453-4057qib7 1043 5 was be VBD cord-005453-4057qib7 1043 6 assessed assess VBN cord-005453-4057qib7 1043 7 by by IN cord-005453-4057qib7 1043 8 measuring measure VBG cord-005453-4057qib7 1043 9 anti anti JJ cord-005453-4057qib7 1043 10 - - JJ cord-005453-4057qib7 1043 11 donor donor JJ cord-005453-4057qib7 1043 12 antibodies antibody NNS cord-005453-4057qib7 1043 13 and and CC cord-005453-4057qib7 1043 14 mixed mixed JJ cord-005453-4057qib7 1043 15 lymphocyte lymphocyte NN cord-005453-4057qib7 1043 16 reaction reaction NN cord-005453-4057qib7 1043 17 ( ( -LRB- cord-005453-4057qib7 1043 18 MLR MLR NNP cord-005453-4057qib7 1043 19 ) ) -RRB- cord-005453-4057qib7 1043 20 against against IN cord-005453-4057qib7 1043 21 donor donor NN cord-005453-4057qib7 1043 22 and and CC cord-005453-4057qib7 1043 23 thirdparty thirdparty NN cord-005453-4057qib7 1043 24 cells cell NNS cord-005453-4057qib7 1043 25 . . . cord-005453-4057qib7 1044 1 Results result NNS cord-005453-4057qib7 1044 2 : : : cord-005453-4057qib7 1045 1 In in IN cord-005453-4057qib7 1045 2 all all DT cord-005453-4057qib7 1045 3 kidney kidney NN cord-005453-4057qib7 1045 4 transplant transplant NN cord-005453-4057qib7 1045 5 recipients recipient NNS cord-005453-4057qib7 1045 6 , , , cord-005453-4057qib7 1045 7 we -PRON- PRP cord-005453-4057qib7 1045 8 observed observe VBD cord-005453-4057qib7 1045 9 a a DT cord-005453-4057qib7 1045 10 median median JJ cord-005453-4057qib7 1045 11 serum serum NN cord-005453-4057qib7 1045 12 creatinine creatinine NN cord-005453-4057qib7 1045 13 of of IN cord-005453-4057qib7 1045 14 1.4 1.4 CD cord-005453-4057qib7 1045 15 mg mg NNP cord-005453-4057qib7 1045 16 / / SYM cord-005453-4057qib7 1045 17 dL dl NN cord-005453-4057qib7 1045 18 at at IN cord-005453-4057qib7 1045 19 day day NN cord-005453-4057qib7 1045 20 30 30 CD cord-005453-4057qib7 1045 21 which which WDT cord-005453-4057qib7 1045 22 remained remain VBD cord-005453-4057qib7 1045 23 stable stable JJ cord-005453-4057qib7 1045 24 until until IN cord-005453-4057qib7 1045 25 day day NN cord-005453-4057qib7 1045 26 360 360 CD cord-005453-4057qib7 1045 27 ( ( -LRB- cord-005453-4057qib7 1045 28 median median JJ cord-005453-4057qib7 1045 29 creatinine creatinine NN cord-005453-4057qib7 1045 30 of of IN cord-005453-4057qib7 1045 31 1.4 1.4 CD cord-005453-4057qib7 1045 32 mg/ mg/ NN cord-005453-4057qib7 1045 33 dL dl NN cord-005453-4057qib7 1045 34 ) ) -RRB- cord-005453-4057qib7 1045 35 without without IN cord-005453-4057qib7 1045 36 significant significant JJ cord-005453-4057qib7 1045 37 proteinuria proteinuria NN cord-005453-4057qib7 1045 38 . . . cord-005453-4057qib7 1046 1 None none NN cord-005453-4057qib7 1046 2 of of IN cord-005453-4057qib7 1046 3 patients patient NNS cord-005453-4057qib7 1046 4 experienced experience VBD cord-005453-4057qib7 1046 5 rejection rejection NN cord-005453-4057qib7 1046 6 episode episode NN cord-005453-4057qib7 1046 7 . . . cord-005453-4057qib7 1047 1 69 69 CD cord-005453-4057qib7 1047 2 AEs ae NNS cord-005453-4057qib7 1047 3 were be VBD cord-005453-4057qib7 1047 4 observed observe VBN cord-005453-4057qib7 1047 5 while while IN cord-005453-4057qib7 1047 6 three three CD cord-005453-4057qib7 1047 7 AEs ae NNS cord-005453-4057qib7 1047 8 being be VBG cord-005453-4057qib7 1047 9 severe severe JJ cord-005453-4057qib7 1047 10 . . . cord-005453-4057qib7 1048 1 Most most RBS cord-005453-4057qib7 1048 2 importantly importantly RB cord-005453-4057qib7 1048 3 , , , cord-005453-4057qib7 1048 4 none none NN cord-005453-4057qib7 1048 5 of of IN cord-005453-4057qib7 1048 6 them -PRON- PRP cord-005453-4057qib7 1048 7 was be VBD cord-005453-4057qib7 1048 8 associated associate VBN cord-005453-4057qib7 1048 9 with with IN cord-005453-4057qib7 1048 10 MICs mic NNS cord-005453-4057qib7 1048 11 transfusion transfusion NN cord-005453-4057qib7 1048 12 . . . cord-005453-4057qib7 1049 1 Besides besides IN cord-005453-4057qib7 1049 2 two two CD cord-005453-4057qib7 1049 3 infectious infectious JJ cord-005453-4057qib7 1049 4 complications complication NNS cord-005453-4057qib7 1049 5 , , , cord-005453-4057qib7 1049 6 no no DT cord-005453-4057qib7 1049 7 post post JJ cord-005453-4057qib7 1049 8 - - JJ cord-005453-4057qib7 1049 9 transplant transplant JJ cord-005453-4057qib7 1049 10 positive positive JJ cord-005453-4057qib7 1049 11 cross cross NN cord-005453-4057qib7 1049 12 match match NN cord-005453-4057qib7 1049 13 results result NNS cord-005453-4057qib7 1049 14 against against IN cord-005453-4057qib7 1049 15 the the DT cord-005453-4057qib7 1049 16 donor donor NN cord-005453-4057qib7 1049 17 or or CC cord-005453-4057qib7 1049 18 titers titer NNS cord-005453-4057qib7 1049 19 of of IN cord-005453-4057qib7 1049 20 de de NNP cord-005453-4057qib7 1049 21 novo novo NNP cord-005453-4057qib7 1049 22 donorspecific donorspecific NNP cord-005453-4057qib7 1049 23 antibodies antibody NNS cord-005453-4057qib7 1049 24 were be VBD cord-005453-4057qib7 1049 25 recorded record VBN cord-005453-4057qib7 1049 26 . . . cord-005453-4057qib7 1050 1 Notably notably RB cord-005453-4057qib7 1050 2 , , , cord-005453-4057qib7 1050 3 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 1050 4 therapy therapy NN cord-005453-4057qib7 1050 5 could could MD cord-005453-4057qib7 1050 6 be be VB cord-005453-4057qib7 1050 7 reduced reduce VBN cord-005453-4057qib7 1050 8 without without IN cord-005453-4057qib7 1050 9 signs sign NNS cord-005453-4057qib7 1050 10 of of IN cord-005453-4057qib7 1050 11 rejection rejection NN cord-005453-4057qib7 1050 12 in in IN cord-005453-4057qib7 1050 13 group group NN cord-005453-4057qib7 1050 14 C. C. NNP cord-005453-4057qib7 1050 15 After after IN cord-005453-4057qib7 1050 16 infusion infusion NN cord-005453-4057qib7 1050 17 , , , cord-005453-4057qib7 1050 18 we -PRON- PRP cord-005453-4057qib7 1050 19 observed observe VBD cord-005453-4057qib7 1050 20 a a DT cord-005453-4057qib7 1050 21 dramatic dramatic JJ cord-005453-4057qib7 1050 22 increase increase NN cord-005453-4057qib7 1050 23 of of IN cord-005453-4057qib7 1050 24 CD19 CD19 NNP cord-005453-4057qib7 1050 25 + + CC cord-005453-4057qib7 1050 26 B b NN cord-005453-4057qib7 1050 27 cells cell NNS cord-005453-4057qib7 1050 28 up up RP cord-005453-4057qib7 1050 29 to to IN cord-005453-4057qib7 1050 30 a a DT cord-005453-4057qib7 1050 31 median median NN cord-005453-4057qib7 1050 32 of of IN cord-005453-4057qib7 1050 33 300 300 CD cord-005453-4057qib7 1050 34 cells/ cells/ CD cord-005453-4057qib7 1051 1 μL μL . cord-005453-4057qib7 1052 1 until until IN cord-005453-4057qib7 1052 2 day day NN cord-005453-4057qib7 1052 3 30 30 CD cord-005453-4057qib7 1052 4 , , , cord-005453-4057qib7 1052 5 followed follow VBN cord-005453-4057qib7 1052 6 by by IN cord-005453-4057qib7 1052 7 a a DT cord-005453-4057qib7 1052 8 reduction reduction NN cord-005453-4057qib7 1052 9 to to IN cord-005453-4057qib7 1052 10 35 35 CD cord-005453-4057qib7 1052 11 cells/ cells/ CD cord-005453-4057qib7 1053 1 μL μL . cord-005453-4057qib7 1054 1 on on IN cord-005453-4057qib7 1054 2 day day NN cord-005453-4057qib7 1054 3 180 180 CD cord-005453-4057qib7 1054 4 in in IN cord-005453-4057qib7 1054 5 group group NN cord-005453-4057qib7 1054 6 C. C. NNP cord-005453-4057qib7 1054 7 Notably notably RB cord-005453-4057qib7 1054 8 , , , cord-005453-4057qib7 1054 9 regulatory regulatory JJ cord-005453-4057qib7 1054 10 B b NN cord-005453-4057qib7 1054 11 cells cell NNS cord-005453-4057qib7 1054 12 significantly significantly RB cord-005453-4057qib7 1054 13 increased increase VBD cord-005453-4057qib7 1054 14 from from IN cord-005453-4057qib7 1054 15 a a DT cord-005453-4057qib7 1054 16 median median NN cord-005453-4057qib7 1054 17 of of IN cord-005453-4057qib7 1054 18 2 2 CD cord-005453-4057qib7 1054 19 % % NN cord-005453-4057qib7 1054 20 on on IN cord-005453-4057qib7 1054 21 day day NN cord-005453-4057qib7 1054 22 30 30 CD cord-005453-4057qib7 1054 23 to to TO cord-005453-4057qib7 1054 24 20 20 CD cord-005453-4057qib7 1054 25 % % NN cord-005453-4057qib7 1054 26 on on IN cord-005453-4057qib7 1054 27 day day NN cord-005453-4057qib7 1054 28 180 180 CD cord-005453-4057qib7 1054 29 . . . cord-005453-4057qib7 1055 1 In in IN cord-005453-4057qib7 1055 2 parallel parallel NN cord-005453-4057qib7 1055 3 , , , cord-005453-4057qib7 1055 4 the the DT cord-005453-4057qib7 1055 5 plasma plasma NN cord-005453-4057qib7 1055 6 IL-10 IL-10 NNP cord-005453-4057qib7 1055 7 / / SYM cord-005453-4057qib7 1055 8 TNF TNF NNP cord-005453-4057qib7 1055 9 - - HYPH cord-005453-4057qib7 1055 10 α α NNP cord-005453-4057qib7 1055 11 ratio ratio NN cord-005453-4057qib7 1055 12 increased increase VBD cord-005453-4057qib7 1055 13 from from IN cord-005453-4057qib7 1055 14 a a DT cord-005453-4057qib7 1055 15 median median NN cord-005453-4057qib7 1055 16 of of IN cord-005453-4057qib7 1055 17 0.05 0.05 CD cord-005453-4057qib7 1055 18 before before IN cord-005453-4057qib7 1055 19 cell cell NN cord-005453-4057qib7 1055 20 therapy therapy NN cord-005453-4057qib7 1055 21 to to IN cord-005453-4057qib7 1055 22 0.11 0.11 CD cord-005453-4057qib7 1055 23 on on IN cord-005453-4057qib7 1055 24 day day NN cord-005453-4057qib7 1055 25 180 180 CD cord-005453-4057qib7 1055 26 . . . cord-005453-4057qib7 1056 1 After after IN cord-005453-4057qib7 1056 2 MIC mic NN cord-005453-4057qib7 1056 3 cell cell NN cord-005453-4057qib7 1056 4 therapy therapy NN cord-005453-4057qib7 1056 5 recipient recipient NN cord-005453-4057qib7 1056 6 lymphocytes lymphocyte NNS cord-005453-4057qib7 1056 7 showed show VBD cord-005453-4057qib7 1056 8 no no DT cord-005453-4057qib7 1056 9 or or CC cord-005453-4057qib7 1056 10 only only JJ cord-005453-4057qib7 1056 11 minimal minimal JJ cord-005453-4057qib7 1056 12 reactivity reactivity NN cord-005453-4057qib7 1056 13 against against IN cord-005453-4057qib7 1056 14 irradiated irradiate VBN cord-005453-4057qib7 1056 15 donor donor NN cord-005453-4057qib7 1056 16 PBMCs pbmc NNS cord-005453-4057qib7 1056 17 in in IN cord-005453-4057qib7 1056 18 vitro vitro FW cord-005453-4057qib7 1056 19 , , , cord-005453-4057qib7 1056 20 while while IN cord-005453-4057qib7 1056 21 reactivity reactivity NN cord-005453-4057qib7 1056 22 against against IN cord-005453-4057qib7 1056 23 3 3 CD cord-005453-4057qib7 1056 24 rd rd NNP cord-005453-4057qib7 1056 25 -party -party JJ cord-005453-4057qib7 1056 26 - - HYPH cord-005453-4057qib7 1056 27 donor donor NN cord-005453-4057qib7 1056 28 PBMCs pbmc NNS cord-005453-4057qib7 1056 29 was be VBD cord-005453-4057qib7 1056 30 not not RB cord-005453-4057qib7 1056 31 impaired impaired JJ cord-005453-4057qib7 1056 32 . . . cord-005453-4057qib7 1057 1 Moreover moreover RB cord-005453-4057qib7 1057 2 , , , cord-005453-4057qib7 1057 3 in in IN cord-005453-4057qib7 1057 4 vitro vitro FW cord-005453-4057qib7 1057 5 MICs mic NNS cord-005453-4057qib7 1057 6 product product NN cord-005453-4057qib7 1057 7 demonstrated demonstrate VBD cord-005453-4057qib7 1057 8 their -PRON- PRP$ cord-005453-4057qib7 1057 9 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 1057 10 potency potency NN cord-005453-4057qib7 1057 11 by by IN cord-005453-4057qib7 1057 12 inducing induce VBG cord-005453-4057qib7 1057 13 tolerogenic tolerogenic NNP cord-005453-4057qib7 1057 14 dendritic dendritic JJ cord-005453-4057qib7 1057 15 cells cell NNS cord-005453-4057qib7 1057 16 ( ( -LRB- cord-005453-4057qib7 1057 17 tDCs tDCs NNP cord-005453-4057qib7 1057 18 ) ) -RRB- cord-005453-4057qib7 1057 19 characterized characterize VBN cord-005453-4057qib7 1057 20 by by IN cord-005453-4057qib7 1057 21 low low JJ cord-005453-4057qib7 1057 22 expression expression NN cord-005453-4057qib7 1057 23 of of IN cord-005453-4057qib7 1057 24 costimulatory costimulatory NNP cord-005453-4057qib7 1057 25 ( ( -LRB- cord-005453-4057qib7 1057 26 CD80 CD80 NNP cord-005453-4057qib7 1057 27 , , , cord-005453-4057qib7 1057 28 CD86 CD86 NNP cord-005453-4057qib7 1057 29 ) ) -RRB- cord-005453-4057qib7 1057 30 and and CC cord-005453-4057qib7 1057 31 maturation maturation NN cord-005453-4057qib7 1057 32 ( ( -LRB- cord-005453-4057qib7 1057 33 CD83 CD83 NNP cord-005453-4057qib7 1057 34 ) ) -RRB- cord-005453-4057qib7 1057 35 as as RB cord-005453-4057qib7 1057 36 well well RB cord-005453-4057qib7 1057 37 as as IN cord-005453-4057qib7 1057 38 high high JJ cord-005453-4057qib7 1057 39 expression expression NN cord-005453-4057qib7 1057 40 of of IN cord-005453-4057qib7 1057 41 inhibitory inhibitory JJ cord-005453-4057qib7 1057 42 marker marker NN cord-005453-4057qib7 1057 43 CD103 CD103 NNP cord-005453-4057qib7 1057 44 . . . cord-005453-4057qib7 1058 1 Functionally functionally RB cord-005453-4057qib7 1058 2 , , , cord-005453-4057qib7 1058 3 tDCs tdcs PRP cord-005453-4057qib7 1058 4 could could MD cord-005453-4057qib7 1058 5 inhibit inhibit VB cord-005453-4057qib7 1058 6 not not RB cord-005453-4057qib7 1058 7 only only RB cord-005453-4057qib7 1058 8 the the DT cord-005453-4057qib7 1058 9 release release NN cord-005453-4057qib7 1058 10 of of IN cord-005453-4057qib7 1058 11 IFN IFN NNP cord-005453-4057qib7 1058 12 - - HYPH cord-005453-4057qib7 1058 13 γ γ NNP cord-005453-4057qib7 1058 14 but but CC cord-005453-4057qib7 1058 15 also also RB cord-005453-4057qib7 1058 16 the the DT cord-005453-4057qib7 1058 17 proliferation proliferation NN cord-005453-4057qib7 1058 18 of of IN cord-005453-4057qib7 1058 19 CMV CMV NNP cord-005453-4057qib7 1058 20 specific specific JJ cord-005453-4057qib7 1058 21 CD8 CD8 NNP cord-005453-4057qib7 1058 22 + + CC cord-005453-4057qib7 1058 23 T t NN cord-005453-4057qib7 1058 24 cells cell NNS cord-005453-4057qib7 1058 25 . . . cord-005453-4057qib7 1059 1 Moreover moreover RB cord-005453-4057qib7 1059 2 , , , cord-005453-4057qib7 1059 3 MIC MIC NNP cord-005453-4057qib7 1059 4 - - HYPH cord-005453-4057qib7 1059 5 induced induce VBN cord-005453-4057qib7 1059 6 tDCs tDCs NNP cord-005453-4057qib7 1059 7 showed show VBD cord-005453-4057qib7 1059 8 the the DT cord-005453-4057qib7 1059 9 capacity capacity NN cord-005453-4057qib7 1059 10 to to TO cord-005453-4057qib7 1059 11 inhibit inhibit VB cord-005453-4057qib7 1059 12 donor donor NN cord-005453-4057qib7 1059 13 - - HYPH cord-005453-4057qib7 1059 14 specific specific JJ cord-005453-4057qib7 1059 15 allo allo NN cord-005453-4057qib7 1059 16 - - HYPH cord-005453-4057qib7 1059 17 reactive reactive JJ cord-005453-4057qib7 1059 18 CD4 CD4 NNP cord-005453-4057qib7 1059 19 + + CC cord-005453-4057qib7 1059 20 and and CC cord-005453-4057qib7 1059 21 CD8 CD8 NNP cord-005453-4057qib7 1059 22 + + CC cord-005453-4057qib7 1059 23 T T NNP cord-005453-4057qib7 1059 24 cell cell NN cord-005453-4057qib7 1059 25 proliferation proliferation NN cord-005453-4057qib7 1059 26 . . . cord-005453-4057qib7 1060 1 Conclusions conclusion NNS cord-005453-4057qib7 1060 2 : : : cord-005453-4057qib7 1061 1 MIC mic NN cord-005453-4057qib7 1061 2 cell cell NN cord-005453-4057qib7 1061 3 therapy therapy NN cord-005453-4057qib7 1061 4 modulates modulate VBZ cord-005453-4057qib7 1061 5 the the DT cord-005453-4057qib7 1061 6 immune immune JJ cord-005453-4057qib7 1061 7 system system NN cord-005453-4057qib7 1061 8 of of IN cord-005453-4057qib7 1061 9 kidney kidney NN cord-005453-4057qib7 1061 10 transplant transplant NN cord-005453-4057qib7 1061 11 recipients recipient NNS cord-005453-4057qib7 1061 12 by by IN cord-005453-4057qib7 1061 13 increasing increase VBG cord-005453-4057qib7 1061 14 the the DT cord-005453-4057qib7 1061 15 ratio ratio NN cord-005453-4057qib7 1061 16 of of IN cord-005453-4057qib7 1061 17 regulatory regulatory JJ cord-005453-4057qib7 1061 18 B b NN cord-005453-4057qib7 1061 19 cells cell NNS cord-005453-4057qib7 1061 20 and and CC cord-005453-4057qib7 1061 21 facilitates facilitate VBZ cord-005453-4057qib7 1061 22 the the DT cord-005453-4057qib7 1061 23 reduction reduction NN cord-005453-4057qib7 1061 24 of of IN cord-005453-4057qib7 1061 25 conventional conventional JJ cord-005453-4057qib7 1061 26 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 1061 27 therapy therapy NN cord-005453-4057qib7 1061 28 without without IN cord-005453-4057qib7 1061 29 allograft allograft NN cord-005453-4057qib7 1061 30 injury injury NN cord-005453-4057qib7 1061 31 or or CC cord-005453-4057qib7 1061 32 rejection rejection NN cord-005453-4057qib7 1061 33 episodes episode NNS cord-005453-4057qib7 1061 34 . . . cord-005453-4057qib7 1062 1 Therefore therefore RB cord-005453-4057qib7 1062 2 , , , cord-005453-4057qib7 1062 3 MIC mic NN cord-005453-4057qib7 1062 4 cell cell NN cord-005453-4057qib7 1062 5 therapy therapy NN cord-005453-4057qib7 1062 6 represents represent VBZ cord-005453-4057qib7 1062 7 a a DT cord-005453-4057qib7 1062 8 promising promising JJ cord-005453-4057qib7 1062 9 strategy strategy NN cord-005453-4057qib7 1062 10 in in IN cord-005453-4057qib7 1062 11 transplantation transplantation NN cord-005453-4057qib7 1062 12 medicine medicine NN cord-005453-4057qib7 1062 13 . . . cord-005453-4057qib7 1063 1 We -PRON- PRP cord-005453-4057qib7 1063 2 currently currently RB cord-005453-4057qib7 1063 3 prepare prepare VBP cord-005453-4057qib7 1063 4 a a DT cord-005453-4057qib7 1063 5 phase phase NN cord-005453-4057qib7 1063 6 II ii CD cord-005453-4057qib7 1063 7 trial trial NN cord-005453-4057qib7 1063 8 with with IN cord-005453-4057qib7 1063 9 MIC mic NN cord-005453-4057qib7 1063 10 cell cell NN cord-005453-4057qib7 1063 11 therapy therapy NN cord-005453-4057qib7 1063 12 . . . cord-005453-4057qib7 1064 1 Disclosure disclosure NN cord-005453-4057qib7 1064 2 : : : cord-005453-4057qib7 1064 3 Nothing nothing NN cord-005453-4057qib7 1064 4 to to TO cord-005453-4057qib7 1064 5 declare declare VB cord-005453-4057qib7 1064 6 P062 P062 NNP cord-005453-4057qib7 1064 7 genome genome NN cord-005453-4057qib7 1064 8 editing editing NN cord-005453-4057qib7 1064 9 of of IN cord-005453-4057qib7 1064 10 graft graft NN cord-005453-4057qib7 1064 11 - - HYPH cord-005453-4057qib7 1064 12 derived derive VBN cord-005453-4057qib7 1064 13 T t NN cord-005453-4057qib7 1064 14 cells cell NNS cord-005453-4057qib7 1064 15 for for IN cord-005453-4057qib7 1064 16 post- post- NN cord-005453-4057qib7 1065 1 Background background NN cord-005453-4057qib7 1065 2 : : : cord-005453-4057qib7 1065 3 Immunotherapy immunotherapy NN cord-005453-4057qib7 1065 4 using use VBG cord-005453-4057qib7 1065 5 CAR CAR NNP cord-005453-4057qib7 1065 6 T T NNP cord-005453-4057qib7 1065 7 cells cell NNS cord-005453-4057qib7 1065 8 has have VBZ cord-005453-4057qib7 1065 9 shown show VBN cord-005453-4057qib7 1065 10 promising promising JJ cord-005453-4057qib7 1065 11 results result NNS cord-005453-4057qib7 1065 12 to to TO cord-005453-4057qib7 1065 13 fight fight VB cord-005453-4057qib7 1065 14 cancer cancer NN cord-005453-4057qib7 1065 15 . . . cord-005453-4057qib7 1066 1 However however RB cord-005453-4057qib7 1066 2 , , , cord-005453-4057qib7 1066 3 CAR car NN cord-005453-4057qib7 1066 4 - - HYPH cord-005453-4057qib7 1066 5 T t NN cord-005453-4057qib7 1066 6 cell cell NN cord-005453-4057qib7 1066 7 production production NN cord-005453-4057qib7 1066 8 requires require VBZ cord-005453-4057qib7 1066 9 specialized specialized JJ cord-005453-4057qib7 1066 10 infrastructure infrastructure NN cord-005453-4057qib7 1066 11 and and CC cord-005453-4057qib7 1066 12 operators operator NNS cord-005453-4057qib7 1066 13 , , , cord-005453-4057qib7 1066 14 which which WDT cord-005453-4057qib7 1066 15 implies imply VBZ cord-005453-4057qib7 1066 16 high high JJ cord-005453-4057qib7 1066 17 cost cost NN cord-005453-4057qib7 1066 18 and and CC cord-005453-4057qib7 1066 19 centralized centralized JJ cord-005453-4057qib7 1066 20 production production NN cord-005453-4057qib7 1066 21 . . . cord-005453-4057qib7 1067 1 Automated automate VBN cord-005453-4057qib7 1067 2 production production NN cord-005453-4057qib7 1067 3 of of IN cord-005453-4057qib7 1067 4 CAR car NN cord-005453-4057qib7 1067 5 - - HYPH cord-005453-4057qib7 1067 6 T t NN cord-005453-4057qib7 1067 7 cells cell NNS cord-005453-4057qib7 1067 8 in in IN cord-005453-4057qib7 1067 9 CliniMACS CliniMACS NNP cord-005453-4057qib7 1067 10 Prodigy Prodigy NNP cord-005453-4057qib7 1067 11 device device NN cord-005453-4057qib7 1067 12 allows allow VBZ cord-005453-4057qib7 1067 13 clinical clinical JJ cord-005453-4057qib7 1067 14 - - HYPH cord-005453-4057qib7 1067 15 grade grade NN cord-005453-4057qib7 1067 16 manufacturing manufacturing NN cord-005453-4057qib7 1067 17 of of IN cord-005453-4057qib7 1067 18 CAR car NN cord-005453-4057qib7 1067 19 T t NN cord-005453-4057qib7 1067 20 cells cell NNS cord-005453-4057qib7 1067 21 . . . cord-005453-4057qib7 1068 1 Methods method NNS cord-005453-4057qib7 1068 2 : : : cord-005453-4057qib7 1068 3 100 100 CD cord-005453-4057qib7 1068 4 million million CD cord-005453-4057qib7 1068 5 CD45RAmemory cd45ramemory CD cord-005453-4057qib7 1068 6 T t NN cord-005453-4057qib7 1068 7 cells cell NNS cord-005453-4057qib7 1068 8 from from IN cord-005453-4057qib7 1068 9 healthy healthy JJ cord-005453-4057qib7 1068 10 donors donor NNS cord-005453-4057qib7 1068 11 were be VBD cord-005453-4057qib7 1068 12 cultured culture VBN cord-005453-4057qib7 1068 13 in in IN cord-005453-4057qib7 1068 14 TexMACS texmacs NN cord-005453-4057qib7 1068 15 supplemented supplement VBN cord-005453-4057qib7 1068 16 with with IN cord-005453-4057qib7 1068 17 100 100 CD cord-005453-4057qib7 1068 18 IU IU NNP cord-005453-4057qib7 1068 19 / / , cord-005453-4057qib7 1068 20 ml ml NN cord-005453-4057qib7 1069 1 IL-2 IL-2 NNP cord-005453-4057qib7 1069 2 . . . cord-005453-4057qib7 1070 1 At at IN cord-005453-4057qib7 1070 2 day day NN cord-005453-4057qib7 1070 3 0 0 CD cord-005453-4057qib7 1070 4 cells cell NNS cord-005453-4057qib7 1070 5 were be VBD cord-005453-4057qib7 1070 6 activated activate VBN cord-005453-4057qib7 1070 7 with with IN cord-005453-4057qib7 1070 8 T T NNP cord-005453-4057qib7 1070 9 Cell Cell NNP cord-005453-4057qib7 1070 10 TransAct TransAct NNP cord-005453-4057qib7 1070 11 for for IN cord-005453-4057qib7 1070 12 24h 24h NNS cord-005453-4057qib7 1070 13 . . . cord-005453-4057qib7 1071 1 At at IN cord-005453-4057qib7 1071 2 day day NN cord-005453-4057qib7 1071 3 one one CD cord-005453-4057qib7 1071 4 , , , cord-005453-4057qib7 1071 5 activated activate VBN cord-005453-4057qib7 1071 6 CD45RAmemory CD45RAmemory NNP cord-005453-4057qib7 1071 7 T t NN cord-005453-4057qib7 1071 8 cells cell NNS cord-005453-4057qib7 1071 9 were be VBD cord-005453-4057qib7 1071 10 transduced transduce VBN cord-005453-4057qib7 1071 11 with with IN cord-005453-4057qib7 1071 12 NKG2D NKG2D NNS cord-005453-4057qib7 1071 13 - - HYPH cord-005453-4057qib7 1071 14 CD8TM-41BB cd8tm-41bb CD cord-005453-4057qib7 1071 15 - - HYPH cord-005453-4057qib7 1071 16 CD3z CD3z NNP cord-005453-4057qib7 1071 17 lentiviral lentiviral JJ cord-005453-4057qib7 1071 18 vector vector NN cord-005453-4057qib7 1071 19 at at IN cord-005453-4057qib7 1071 20 MOI MOI NNP cord-005453-4057qib7 1071 21 = = SYM cord-005453-4057qib7 1071 22 2 2 CD cord-005453-4057qib7 1071 23 . . . cord-005453-4057qib7 1072 1 Then then RB cord-005453-4057qib7 1072 2 , , , cord-005453-4057qib7 1072 3 NKG2D nkg2d NN cord-005453-4057qib7 1072 4 - - HYPH cord-005453-4057qib7 1072 5 CAR car NN cord-005453-4057qib7 1072 6 T t NN cord-005453-4057qib7 1072 7 cells cell NNS cord-005453-4057qib7 1072 8 were be VBD cord-005453-4057qib7 1072 9 expanded expand VBN cord-005453-4057qib7 1072 10 for for IN cord-005453-4057qib7 1072 11 10 10 CD cord-005453-4057qib7 1072 12 - - SYM cord-005453-4057qib7 1072 13 13 13 CD cord-005453-4057qib7 1072 14 days day NNS cord-005453-4057qib7 1072 15 . . . cord-005453-4057qib7 1073 1 NKG2D nkg2d NN cord-005453-4057qib7 1073 2 - - HYPH cord-005453-4057qib7 1073 3 CAR car NN cord-005453-4057qib7 1073 4 T t NN cord-005453-4057qib7 1073 5 cell cell NN cord-005453-4057qib7 1073 6 products product NNS cord-005453-4057qib7 1073 7 were be VBD cord-005453-4057qib7 1073 8 next next RB cord-005453-4057qib7 1073 9 harvested harvest VBN cord-005453-4057qib7 1073 10 , , , cord-005453-4057qib7 1073 11 counted count VBN cord-005453-4057qib7 1073 12 and and CC cord-005453-4057qib7 1073 13 analyzed analyze VBN cord-005453-4057qib7 1073 14 for for IN cord-005453-4057qib7 1073 15 viability viability NN cord-005453-4057qib7 1073 16 , , , cord-005453-4057qib7 1073 17 NKG2D nkg2d NN cord-005453-4057qib7 1073 18 - - HYPH cord-005453-4057qib7 1073 19 CAR car NN cord-005453-4057qib7 1073 20 expression expression NN cord-005453-4057qib7 1073 21 and and CC cord-005453-4057qib7 1073 22 anti anti JJ cord-005453-4057qib7 1073 23 - - JJ cord-005453-4057qib7 1073 24 tumor tumor JJ cord-005453-4057qib7 1073 25 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1073 26 . . . cord-005453-4057qib7 1074 1 Different different JJ cord-005453-4057qib7 1074 2 quality quality NN cord-005453-4057qib7 1074 3 tests test NNS cord-005453-4057qib7 1074 4 including include VBG cord-005453-4057qib7 1074 5 sterility sterility NN cord-005453-4057qib7 1074 6 , , , cord-005453-4057qib7 1074 7 vector vector NN cord-005453-4057qib7 1074 8 copy copy NN cord-005453-4057qib7 1074 9 number number NN cord-005453-4057qib7 1074 10 , , , cord-005453-4057qib7 1074 11 genetic genetic JJ cord-005453-4057qib7 1074 12 stability stability NN cord-005453-4057qib7 1074 13 , , , cord-005453-4057qib7 1074 14 quantification quantification NN cord-005453-4057qib7 1074 15 of of IN cord-005453-4057qib7 1074 16 viral viral JJ cord-005453-4057qib7 1074 17 particles particle NNS cord-005453-4057qib7 1074 18 in in IN cord-005453-4057qib7 1074 19 the the DT cord-005453-4057qib7 1074 20 supernatant supernatant NN cord-005453-4057qib7 1074 21 , , , cord-005453-4057qib7 1074 22 myc myc NNP cord-005453-4057qib7 1074 23 / / SYM cord-005453-4057qib7 1074 24 tert tert NNP cord-005453-4057qib7 1074 25 expression expression NN cord-005453-4057qib7 1074 26 and and CC cord-005453-4057qib7 1074 27 endotoxin endotoxin NN cord-005453-4057qib7 1074 28 detection detection NN cord-005453-4057qib7 1074 29 were be VBD cord-005453-4057qib7 1074 30 performed perform VBN cord-005453-4057qib7 1074 31 . . . cord-005453-4057qib7 1075 1 Spare spare JJ cord-005453-4057qib7 1075 2 cells cell NNS cord-005453-4057qib7 1075 3 were be VBD cord-005453-4057qib7 1075 4 cryopreserved cryopreserve VBN cord-005453-4057qib7 1075 5 either either CC cord-005453-4057qib7 1075 6 in in IN cord-005453-4057qib7 1075 7 autologous autologous JJ cord-005453-4057qib7 1075 8 plasma plasma NN cord-005453-4057qib7 1075 9 and and CC cord-005453-4057qib7 1075 10 10 10 CD cord-005453-4057qib7 1075 11 % % NN cord-005453-4057qib7 1075 12 DMSO DMSO NNP cord-005453-4057qib7 1075 13 , , , cord-005453-4057qib7 1075 14 M199 m199 $ cord-005453-4057qib7 1075 15 35 35 CD cord-005453-4057qib7 1075 16 % % NN cord-005453-4057qib7 1075 17 Albumin albumin NN cord-005453-4057qib7 1075 18 and and CC cord-005453-4057qib7 1075 19 9%DMSO 9%dmso CD cord-005453-4057qib7 1075 20 or or CC cord-005453-4057qib7 1075 21 Hypothermosol Hypothermosol NNP cord-005453-4057qib7 1075 22 . . . cord-005453-4057qib7 1076 1 After after IN cord-005453-4057qib7 1076 2 12 12 CD cord-005453-4057qib7 1076 3 months month NNS cord-005453-4057qib7 1076 4 , , , cord-005453-4057qib7 1076 5 cryopreserved cryopreserve VBN cord-005453-4057qib7 1076 6 NKG2D nkg2d NN cord-005453-4057qib7 1076 7 - - HYPH cord-005453-4057qib7 1076 8 CAR car NN cord-005453-4057qib7 1076 9 T t NN cord-005453-4057qib7 1076 10 cell cell NN cord-005453-4057qib7 1076 11 products product NNS cord-005453-4057qib7 1076 12 were be VBD cord-005453-4057qib7 1076 13 analyzed analyze VBN cord-005453-4057qib7 1076 14 for for IN cord-005453-4057qib7 1076 15 viability viability NN cord-005453-4057qib7 1076 16 , , , cord-005453-4057qib7 1076 17 NKG2D nkg2d NN cord-005453-4057qib7 1076 18 - - HYPH cord-005453-4057qib7 1076 19 CAR car NN cord-005453-4057qib7 1076 20 expression expression NN cord-005453-4057qib7 1076 21 and and CC cord-005453-4057qib7 1076 22 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1076 23 . . . cord-005453-4057qib7 1077 1 Results result NNS cord-005453-4057qib7 1077 2 : : : cord-005453-4057qib7 1078 1 NKG2D nkg2d JJ cord-005453-4057qib7 1078 2 - - HYPH cord-005453-4057qib7 1078 3 CAR car NN cord-005453-4057qib7 1078 4 memory memory NN cord-005453-4057qib7 1078 5 T T NNP cord-005453-4057qib7 1078 6 cells cell NNS cord-005453-4057qib7 1078 7 expanded expand VBD cord-005453-4057qib7 1078 8 up up IN cord-005453-4057qib7 1078 9 to to IN cord-005453-4057qib7 1078 10 2076 2076 CD cord-005453-4057qib7 1078 11 ± ± CD cord-005453-4057qib7 1078 12 697 697 CD cord-005453-4057qib7 1078 13 million million CD cord-005453-4057qib7 1078 14 with with IN cord-005453-4057qib7 1078 15 77,8 77,8 CD cord-005453-4057qib7 1078 16 ± ± CD cord-005453-4057qib7 1078 17 20 20 CD cord-005453-4057qib7 1078 18 % % NN cord-005453-4057qib7 1078 19 NKG2D nkg2d JJ cord-005453-4057qib7 1078 20 - - HYPH cord-005453-4057qib7 1078 21 CAR car NN cord-005453-4057qib7 1078 22 expression expression NN cord-005453-4057qib7 1078 23 and and CC cord-005453-4057qib7 1078 24 76 76 CD cord-005453-4057qib7 1078 25 ± ± CD cord-005453-4057qib7 1078 26 10 10 CD cord-005453-4057qib7 1078 27 % % NN cord-005453-4057qib7 1078 28 viability viability NN cord-005453-4057qib7 1078 29 . . . cord-005453-4057qib7 1079 1 Harvested harvest VBN cord-005453-4057qib7 1079 2 CAR car NN cord-005453-4057qib7 1079 3 T t NN cord-005453-4057qib7 1079 4 cells cell NNS cord-005453-4057qib7 1079 5 showed show VBD cord-005453-4057qib7 1079 6 90 90 CD cord-005453-4057qib7 1079 7 ± ± CD cord-005453-4057qib7 1079 8 14 14 CD cord-005453-4057qib7 1079 9 % % NN cord-005453-4057qib7 1079 10 of of IN cord-005453-4057qib7 1079 11 specific specific JJ cord-005453-4057qib7 1079 12 lysis lysis NN cord-005453-4057qib7 1079 13 against against IN cord-005453-4057qib7 1079 14 Jurkat Jurkat NNP cord-005453-4057qib7 1079 15 cells cell NNS cord-005453-4057qib7 1079 16 and and CC cord-005453-4057qib7 1079 17 31 31 CD cord-005453-4057qib7 1079 18 ± ± CD cord-005453-4057qib7 1079 19 16 16 CD cord-005453-4057qib7 1079 20 % % NN cord-005453-4057qib7 1079 21 against against IN cord-005453-4057qib7 1079 22 531MII 531mii CD cord-005453-4057qib7 1079 23 osteosarcoma osteosarcoma NN cord-005453-4057qib7 1079 24 cell cell NN cord-005453-4057qib7 1079 25 line line NN cord-005453-4057qib7 1079 26 . . . cord-005453-4057qib7 1080 1 No no DT cord-005453-4057qib7 1080 2 microbiological microbiological JJ cord-005453-4057qib7 1080 3 contamination contamination NN cord-005453-4057qib7 1080 4 was be VBD cord-005453-4057qib7 1080 5 observed observe VBN cord-005453-4057qib7 1080 6 in in IN cord-005453-4057qib7 1080 7 final final JJ cord-005453-4057qib7 1080 8 CAR car NN cord-005453-4057qib7 1080 9 T T NNP cord-005453-4057qib7 1080 10 cells cell NNS cord-005453-4057qib7 1080 11 products product NNS cord-005453-4057qib7 1080 12 . . . cord-005453-4057qib7 1081 1 Vector Vector NNP cord-005453-4057qib7 1081 2 copy copy NN cord-005453-4057qib7 1081 3 number number NN cord-005453-4057qib7 1081 4 was be VBD cord-005453-4057qib7 1081 5 ≤5 ≤5 NN cord-005453-4057qib7 1081 6 in in IN cord-005453-4057qib7 1081 7 all all DT cord-005453-4057qib7 1081 8 validations validation NNS cord-005453-4057qib7 1081 9 except except IN cord-005453-4057qib7 1081 10 for for IN cord-005453-4057qib7 1081 11 one one CD cord-005453-4057qib7 1081 12 . . . cord-005453-4057qib7 1082 1 CGH CGH NNP cord-005453-4057qib7 1082 2 and and CC cord-005453-4057qib7 1082 3 karyotype karyotype NN cord-005453-4057qib7 1082 4 showed show VBD cord-005453-4057qib7 1082 5 no no DT cord-005453-4057qib7 1082 6 genetic genetic JJ cord-005453-4057qib7 1082 7 alterations alteration NNS cord-005453-4057qib7 1082 8 . . . cord-005453-4057qib7 1083 1 Free free JJ cord-005453-4057qib7 1083 2 viral viral JJ cord-005453-4057qib7 1083 3 particles particle NNS cord-005453-4057qib7 1083 4 were be VBD cord-005453-4057qib7 1083 5 undetectable undetectable JJ cord-005453-4057qib7 1083 6 in in IN cord-005453-4057qib7 1083 7 the the DT cord-005453-4057qib7 1083 8 supernatants supernatant NNS cord-005453-4057qib7 1083 9 . . . cord-005453-4057qib7 1084 1 No no DT cord-005453-4057qib7 1084 2 overexpression overexpression NN cord-005453-4057qib7 1084 3 of of IN cord-005453-4057qib7 1084 4 myc myc NNP cord-005453-4057qib7 1084 5 / / SYM cord-005453-4057qib7 1084 6 tert tert NNP cord-005453-4057qib7 1084 7 was be VBD cord-005453-4057qib7 1084 8 found find VBN cord-005453-4057qib7 1084 9 except except IN cord-005453-4057qib7 1084 10 for for IN cord-005453-4057qib7 1084 11 one one CD cord-005453-4057qib7 1084 12 validation validation NN cord-005453-4057qib7 1084 13 . . . cord-005453-4057qib7 1085 1 Endotoxins endotoxin NNS cord-005453-4057qib7 1085 2 were be VBD cord-005453-4057qib7 1085 3 ≤0.25EU ≤0.25eu NN cord-005453-4057qib7 1085 4 / / SYM cord-005453-4057qib7 1085 5 ml ml NN cord-005453-4057qib7 1085 6 . . . cord-005453-4057qib7 1086 1 All all DT cord-005453-4057qib7 1086 2 cryopreserved cryopreserve VBN cord-005453-4057qib7 1086 3 NKG2D nkg2d NN cord-005453-4057qib7 1086 4 - - HYPH cord-005453-4057qib7 1086 5 CAR car NN cord-005453-4057qib7 1086 6 T t NN cord-005453-4057qib7 1086 7 cell cell NN cord-005453-4057qib7 1086 8 products product NNS cord-005453-4057qib7 1086 9 kept keep VBD cord-005453-4057qib7 1086 10 NKG2D nkg2d CD cord-005453-4057qib7 1086 11 - - HYPH cord-005453-4057qib7 1086 12 CAR car NN cord-005453-4057qib7 1086 13 expression expression NN cord-005453-4057qib7 1086 14 one one CD cord-005453-4057qib7 1086 15 year year NN cord-005453-4057qib7 1086 16 after after IN cord-005453-4057qib7 1086 17 freezing freeze VBG cord-005453-4057qib7 1086 18 . . . cord-005453-4057qib7 1087 1 However however RB cord-005453-4057qib7 1087 2 , , , cord-005453-4057qib7 1087 3 viability viability NN cord-005453-4057qib7 1087 4 and and CC cord-005453-4057qib7 1087 5 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1087 6 was be VBD cord-005453-4057qib7 1087 7 best well RBS cord-005453-4057qib7 1087 8 preserved preserve VBN cord-005453-4057qib7 1087 9 using use VBG cord-005453-4057qib7 1087 10 autologous autologous JJ cord-005453-4057qib7 1087 11 plasma plasma NN cord-005453-4057qib7 1087 12 10%DMSO 10%dmso CD cord-005453-4057qib7 1087 13 . . . cord-005453-4057qib7 1088 1 Conclusions conclusion NNS cord-005453-4057qib7 1088 2 : : : cord-005453-4057qib7 1089 1 Automated automate VBN cord-005453-4057qib7 1089 2 production production NN cord-005453-4057qib7 1089 3 of of IN cord-005453-4057qib7 1089 4 large large JJ cord-005453-4057qib7 1089 5 - - HYPH cord-005453-4057qib7 1089 6 scale scale NN cord-005453-4057qib7 1089 7 clinical clinical JJ cord-005453-4057qib7 1089 8 - - HYPH cord-005453-4057qib7 1089 9 grade grade NN cord-005453-4057qib7 1089 10 NKG2D nkg2d JJ cord-005453-4057qib7 1089 11 - - HYPH cord-005453-4057qib7 1089 12 CAR car NN cord-005453-4057qib7 1089 13 T t NN cord-005453-4057qib7 1089 14 cells cell NNS cord-005453-4057qib7 1089 15 using use VBG cord-005453-4057qib7 1089 16 CliniMACS CliniMACS NNP cord-005453-4057qib7 1089 17 Prodigy Prodigy NNP cord-005453-4057qib7 1089 18 is be VBZ cord-005453-4057qib7 1089 19 feasible feasible JJ cord-005453-4057qib7 1089 20 and and CC cord-005453-4057qib7 1089 21 reproducible reproducible JJ cord-005453-4057qib7 1089 22 , , , cord-005453-4057qib7 1089 23 allowing allow VBG cord-005453-4057qib7 1089 24 a a DT cord-005453-4057qib7 1089 25 decentralized decentralized JJ cord-005453-4057qib7 1089 26 protocol protocol NN cord-005453-4057qib7 1089 27 to to TO cord-005453-4057qib7 1089 28 generate generate VB cord-005453-4057qib7 1089 29 CAR car NN cord-005453-4057qib7 1089 30 T t NN cord-005453-4057qib7 1089 31 cells cell NNS cord-005453-4057qib7 1089 32 for for IN cord-005453-4057qib7 1089 33 clinical clinical JJ cord-005453-4057qib7 1089 34 use use NN cord-005453-4057qib7 1089 35 . . . cord-005453-4057qib7 1090 1 Background background NN cord-005453-4057qib7 1090 2 : : : cord-005453-4057qib7 1091 1 Immune immune JJ cord-005453-4057qib7 1091 2 Reconstitution reconstitution NN cord-005453-4057qib7 1091 3 ( ( -LRB- cord-005453-4057qib7 1091 4 IR IR NNP cord-005453-4057qib7 1091 5 ) ) -RRB- cord-005453-4057qib7 1091 6 is be VBZ cord-005453-4057qib7 1091 7 essential essential JJ cord-005453-4057qib7 1091 8 to to TO cord-005453-4057qib7 1091 9 control control VB cord-005453-4057qib7 1091 10 severe severe JJ cord-005453-4057qib7 1091 11 infections infection NNS cord-005453-4057qib7 1091 12 after after IN cord-005453-4057qib7 1091 13 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 1091 14 Stem Stem NNP cord-005453-4057qib7 1091 15 Cell Cell NNP cord-005453-4057qib7 1091 16 Transplantation transplantation NN cord-005453-4057qib7 1091 17 ( ( -LRB- cord-005453-4057qib7 1091 18 HSCT HSCT NNP cord-005453-4057qib7 1091 19 ) ) -RRB- cord-005453-4057qib7 1091 20 . . . cord-005453-4057qib7 1092 1 Reconstitution reconstitution NN cord-005453-4057qib7 1092 2 of of IN cord-005453-4057qib7 1092 3 adaptive adaptive JJ cord-005453-4057qib7 1092 4 immunity immunity NN cord-005453-4057qib7 1092 5 may may MD cord-005453-4057qib7 1092 6 take take VB cord-005453-4057qib7 1092 7 up up IN cord-005453-4057qib7 1092 8 to to TO cord-005453-4057qib7 1092 9 2 2 CD cord-005453-4057qib7 1092 10 years year NNS cord-005453-4057qib7 1092 11 to to TO cord-005453-4057qib7 1092 12 recover recover VB cord-005453-4057qib7 1092 13 T T NNP cord-005453-4057qib7 1092 14 - - HYPH cord-005453-4057qib7 1092 15 Lymphocytes Lymphocytes NNP cord-005453-4057qib7 1092 16 ( ( -LRB- cord-005453-4057qib7 1092 17 LT LT NNP cord-005453-4057qib7 1092 18 ) ) -RRB- cord-005453-4057qib7 1092 19 . . . cord-005453-4057qib7 1093 1 Delay delay VB cord-005453-4057qib7 1093 2 in in IN cord-005453-4057qib7 1093 3 early early JJ cord-005453-4057qib7 1093 4 LT LT NNP cord-005453-4057qib7 1093 5 recovery recovery NN cord-005453-4057qib7 1093 6 increases increase VBZ cord-005453-4057qib7 1093 7 the the DT cord-005453-4057qib7 1093 8 risk risk NN cord-005453-4057qib7 1093 9 of of IN cord-005453-4057qib7 1093 10 relapse relapse NN cord-005453-4057qib7 1093 11 , , , cord-005453-4057qib7 1093 12 viral viral JJ cord-005453-4057qib7 1093 13 infections infection NNS cord-005453-4057qib7 1093 14 and and CC cord-005453-4057qib7 1093 15 transplant transplant NN cord-005453-4057qib7 1093 16 related relate VBN cord-005453-4057qib7 1093 17 mortality mortality NN cord-005453-4057qib7 1093 18 . . . cord-005453-4057qib7 1094 1 Adoptive adoptive JJ cord-005453-4057qib7 1094 2 transfer transfer NN cord-005453-4057qib7 1094 3 of of IN cord-005453-4057qib7 1094 4 selected select VBN cord-005453-4057qib7 1094 5 T t NN cord-005453-4057qib7 1094 6 cell cell NN cord-005453-4057qib7 1094 7 subset subset VBN cord-005453-4057qib7 1094 8 with with IN cord-005453-4057qib7 1094 9 low low JJ cord-005453-4057qib7 1094 10 alloreactivity alloreactivity NN cord-005453-4057qib7 1094 11 potential potential NN cord-005453-4057qib7 1094 12 is be VBZ cord-005453-4057qib7 1094 13 emerging emerge VBG cord-005453-4057qib7 1094 14 as as IN cord-005453-4057qib7 1094 15 a a DT cord-005453-4057qib7 1094 16 strategy strategy NN cord-005453-4057qib7 1094 17 to to TO cord-005453-4057qib7 1094 18 improve improve VB cord-005453-4057qib7 1094 19 IR IR NNP cord-005453-4057qib7 1094 20 . . . cord-005453-4057qib7 1095 1 Methods method NNS cord-005453-4057qib7 1095 2 : : : cord-005453-4057qib7 1095 3 Depletion depletion NN cord-005453-4057qib7 1095 4 of of IN cord-005453-4057qib7 1095 5 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 1095 6 naive naive JJ cord-005453-4057qib7 1095 7 T T NNP cord-005453-4057qib7 1095 8 cells cell NNS cord-005453-4057qib7 1095 9 , , , cord-005453-4057qib7 1095 10 preserving preserve VBG cord-005453-4057qib7 1095 11 CD45RO+ cd45ro+ NN cord-005453-4057qib7 1095 12 memory memory NN cord-005453-4057qib7 1095 13 T t NN cord-005453-4057qib7 1095 14 cells cell NNS cord-005453-4057qib7 1095 15 could could MD cord-005453-4057qib7 1095 16 provide provide VB cord-005453-4057qib7 1095 17 functional functional JJ cord-005453-4057qib7 1095 18 lymphocytes lymphocyte NNS cord-005453-4057qib7 1095 19 to to TO cord-005453-4057qib7 1095 20 protect protect VB cord-005453-4057qib7 1095 21 against against IN cord-005453-4057qib7 1095 22 infection infection NN cord-005453-4057qib7 1095 23 and and CC cord-005453-4057qib7 1095 24 leukemia leukemia NN cord-005453-4057qib7 1095 25 relapse relapse NN cord-005453-4057qib7 1095 26 with with IN cord-005453-4057qib7 1095 27 low low JJ cord-005453-4057qib7 1095 28 risk risk NN cord-005453-4057qib7 1095 29 of of IN cord-005453-4057qib7 1095 30 graft graft NN cord-005453-4057qib7 1095 31 versus versus IN cord-005453-4057qib7 1095 32 host host NN cord-005453-4057qib7 1095 33 disease disease NN cord-005453-4057qib7 1095 34 ( ( -LRB- cord-005453-4057qib7 1095 35 GvHD GvHD NNP cord-005453-4057qib7 1095 36 ) ) -RRB- cord-005453-4057qib7 1095 37 . . . cord-005453-4057qib7 1096 1 We -PRON- PRP cord-005453-4057qib7 1096 2 present present VBP cord-005453-4057qib7 1096 3 our -PRON- PRP$ cord-005453-4057qib7 1096 4 experience experience NN cord-005453-4057qib7 1096 5 with with IN cord-005453-4057qib7 1096 6 high high JJ cord-005453-4057qib7 1096 7 - - HYPH cord-005453-4057qib7 1096 8 dose dose NN cord-005453-4057qib7 1096 9 donor donor NN cord-005453-4057qib7 1096 10 CD45RO cd45ro NN cord-005453-4057qib7 1096 11 + + CC cord-005453-4057qib7 1096 12 memory memory NN cord-005453-4057qib7 1096 13 T t NN cord-005453-4057qib7 1096 14 cell cell NN cord-005453-4057qib7 1096 15 as as IN cord-005453-4057qib7 1096 16 donor donor NN cord-005453-4057qib7 1096 17 lymphocyte lymphocyte NN cord-005453-4057qib7 1096 18 Infusions infusion NNS cord-005453-4057qib7 1096 19 ( ( -LRB- cord-005453-4057qib7 1096 20 DLI DLI NNP cord-005453-4057qib7 1096 21 ) ) -RRB- cord-005453-4057qib7 1096 22 to to TO cord-005453-4057qib7 1096 23 assess assess VB cord-005453-4057qib7 1096 24 safety safety NN cord-005453-4057qib7 1096 25 and and CC cord-005453-4057qib7 1096 26 outcome outcome NN cord-005453-4057qib7 1096 27 . . . cord-005453-4057qib7 1097 1 A a DT cord-005453-4057qib7 1097 2 total total NN cord-005453-4057qib7 1097 3 of of IN cord-005453-4057qib7 1097 4 58 58 CD cord-005453-4057qib7 1097 5 DLI DLI NNP cord-005453-4057qib7 1097 6 of of IN cord-005453-4057qib7 1097 7 CD45RO+ CD45RO+ NNP cord-005453-4057qib7 1097 8 after after IN cord-005453-4057qib7 1097 9 HSCT HSCT NNP cord-005453-4057qib7 1097 10 was be VBD cord-005453-4057qib7 1097 11 performed perform VBN cord-005453-4057qib7 1097 12 in in IN cord-005453-4057qib7 1097 13 cases case NNS cord-005453-4057qib7 1097 14 of of IN cord-005453-4057qib7 1097 15 CMV CMV NNP cord-005453-4057qib7 1097 16 / / SYM cord-005453-4057qib7 1097 17 EBV EBV NNP cord-005453-4057qib7 1097 18 reactivation reactivation NN cord-005453-4057qib7 1097 19 ( ( -LRB- cord-005453-4057qib7 1097 20 50 50 CD cord-005453-4057qib7 1097 21 % % NN cord-005453-4057qib7 1097 22 ) ) -RRB- cord-005453-4057qib7 1097 23 , , , cord-005453-4057qib7 1097 24 mixed mixed JJ cord-005453-4057qib7 1097 25 chimerism chimerism NN cord-005453-4057qib7 1097 26 ( ( -LRB- cord-005453-4057qib7 1097 27 26 26 CD cord-005453-4057qib7 1097 28 % % NN cord-005453-4057qib7 1097 29 ) ) -RRB- cord-005453-4057qib7 1097 30 , , , cord-005453-4057qib7 1097 31 persistent persistent JJ cord-005453-4057qib7 1097 32 lymphopenia lymphopenia NNP cord-005453-4057qib7 1097 33 ( ( -LRB- cord-005453-4057qib7 1097 34 8,5 8,5 CD cord-005453-4057qib7 1097 35 % % NN cord-005453-4057qib7 1097 36 ) ) -RRB- cord-005453-4057qib7 1097 37 , , , cord-005453-4057qib7 1097 38 graft graft NN cord-005453-4057qib7 1097 39 rejection rejection NN cord-005453-4057qib7 1097 40 ( ( -LRB- cord-005453-4057qib7 1097 41 3,5 3,5 CD cord-005453-4057qib7 1097 42 % % NN cord-005453-4057qib7 1097 43 ) ) -RRB- cord-005453-4057qib7 1097 44 , , . cord-005453-4057qib7 1098 1 relapse relapse NN cord-005453-4057qib7 1098 2 ( ( -LRB- cord-005453-4057qib7 1098 3 3 3 CD cord-005453-4057qib7 1098 4 % % NN cord-005453-4057qib7 1098 5 ) ) -RRB- cord-005453-4057qib7 1098 6 or or CC cord-005453-4057qib7 1098 7 to to TO cord-005453-4057qib7 1098 8 boost boost VB cord-005453-4057qib7 1098 9 IR IR NNP cord-005453-4057qib7 1098 10 ( ( -LRB- cord-005453-4057qib7 1098 11 7 7 CD cord-005453-4057qib7 1098 12 % % NN cord-005453-4057qib7 1098 13 ) ) -RRB- cord-005453-4057qib7 1098 14 . . . cord-005453-4057qib7 1099 1 DLI DLI NNP cord-005453-4057qib7 1099 2 product product NN cord-005453-4057qib7 1099 3 was be VBD cord-005453-4057qib7 1099 4 obtained obtain VBN cord-005453-4057qib7 1099 5 performing perform VBG cord-005453-4057qib7 1099 6 a a DT cord-005453-4057qib7 1099 7 CD45RA cd45ra NN cord-005453-4057qib7 1099 8 depletion depletion NN cord-005453-4057qib7 1099 9 on on IN cord-005453-4057qib7 1099 10 donor donor NN cord-005453-4057qib7 1099 11 leukapheresis leukapheresis NN cord-005453-4057qib7 1099 12 product product NN cord-005453-4057qib7 1099 13 using use VBG cord-005453-4057qib7 1099 14 the the DT cord-005453-4057qib7 1099 15 CliniMACS CliniMACS NNP cord-005453-4057qib7 1099 16 ® ® NN cord-005453-4057qib7 1099 17 device device NN cord-005453-4057qib7 1099 18 . . . cord-005453-4057qib7 1100 1 Results result NNS cord-005453-4057qib7 1100 2 : : : cord-005453-4057qib7 1101 1 Twenty twenty CD cord-005453-4057qib7 1101 2 - - HYPH cord-005453-4057qib7 1101 3 two two CD cord-005453-4057qib7 1101 4 pediatric pediatric JJ cord-005453-4057qib7 1101 5 patients patient NNS cord-005453-4057qib7 1101 6 , , , cord-005453-4057qib7 1101 7 median median JJ cord-005453-4057qib7 1101 8 age age NN cord-005453-4057qib7 1101 9 11 11 CD cord-005453-4057qib7 1101 10 years year NNS cord-005453-4057qib7 1101 11 ( ( -LRB- cord-005453-4057qib7 1101 12 range range VBP cord-005453-4057qib7 1101 13 3 3 CD cord-005453-4057qib7 1101 14 - - SYM cord-005453-4057qib7 1101 15 18 18 CD cord-005453-4057qib7 1101 16 ) ) -RRB- cord-005453-4057qib7 1101 17 , , , cord-005453-4057qib7 1101 18 with with IN cord-005453-4057qib7 1101 19 malignant malignant JJ cord-005453-4057qib7 1101 20 ( ( -LRB- cord-005453-4057qib7 1101 21 n=15 n=15 NNP cord-005453-4057qib7 1101 22 ) ) -RRB- cord-005453-4057qib7 1101 23 and and CC cord-005453-4057qib7 1101 24 nonmalignant nonmalignant NNP cord-005453-4057qib7 1101 25 diseases disease NNS cord-005453-4057qib7 1101 26 ( ( -LRB- cord-005453-4057qib7 1101 27 7 7 CD cord-005453-4057qib7 1101 28 ) ) -RRB- cord-005453-4057qib7 1101 29 , , , cord-005453-4057qib7 1101 30 received receive VBD cord-005453-4057qib7 1101 31 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 1101 32 ( ( -LRB- cord-005453-4057qib7 1101 33 n=14 n=14 NNP cord-005453-4057qib7 1101 34 ) ) -RRB- cord-005453-4057qib7 1101 35 , , , cord-005453-4057qib7 1101 36 TCR TCR NNP cord-005453-4057qib7 1101 37 alpha alpha NN cord-005453-4057qib7 1101 38 / / SYM cord-005453-4057qib7 1101 39 beta beta NN cord-005453-4057qib7 1101 40 ( ( -LRB- cord-005453-4057qib7 1101 41 n=2 n=2 NNS cord-005453-4057qib7 1101 42 ) ) -RRB- cord-005453-4057qib7 1101 43 depleted deplete VBD cord-005453-4057qib7 1101 44 grafts graft NNS cord-005453-4057qib7 1101 45 from from IN cord-005453-4057qib7 1101 46 haploidentical haploidentical JJ cord-005453-4057qib7 1101 47 and and CC cord-005453-4057qib7 1101 48 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 1102 1 depleted deplete VBN cord-005453-4057qib7 1102 2 grafts graft NNS cord-005453-4057qib7 1102 3 from from IN cord-005453-4057qib7 1102 4 match match NN cord-005453-4057qib7 1102 5 unrelated unrelated JJ cord-005453-4057qib7 1102 6 ( ( -LRB- cord-005453-4057qib7 1102 7 n=6 n=6 JJ cord-005453-4057qib7 1102 8 ) ) -RRB- cord-005453-4057qib7 1102 9 and and CC cord-005453-4057qib7 1102 10 match match VB cord-005453-4057qib7 1102 11 related relate VBN cord-005453-4057qib7 1102 12 ( ( -LRB- cord-005453-4057qib7 1102 13 n=2 n=2 NNS cord-005453-4057qib7 1102 14 ) ) -RRB- cord-005453-4057qib7 1102 15 donors donor NNS cord-005453-4057qib7 1102 16 . . . cord-005453-4057qib7 1103 1 At at IN cord-005453-4057qib7 1103 2 a a DT cord-005453-4057qib7 1103 3 median median NN cord-005453-4057qib7 1103 4 of of IN cord-005453-4057qib7 1103 5 97 97 CD cord-005453-4057qib7 1103 6 days day NNS cord-005453-4057qib7 1103 7 ( ( -LRB- cord-005453-4057qib7 1103 8 range range VBP cord-005453-4057qib7 1103 9 15 15 CD cord-005453-4057qib7 1103 10 - - SYM cord-005453-4057qib7 1103 11 462 462 CD cord-005453-4057qib7 1103 12 ) ) -RRB- cord-005453-4057qib7 1103 13 after after IN cord-005453-4057qib7 1103 14 transplantation transplantation NN cord-005453-4057qib7 1103 15 , , , cord-005453-4057qib7 1103 16 patients patient NNS cord-005453-4057qib7 1103 17 received receive VBD cord-005453-4057qib7 1103 18 a a DT cord-005453-4057qib7 1103 19 total total NN cord-005453-4057qib7 1103 20 of of IN cord-005453-4057qib7 1103 21 58 58 CD cord-005453-4057qib7 1103 22 DLI DLI NNP cord-005453-4057qib7 1103 23 of of IN cord-005453-4057qib7 1103 24 CD45RO+ CD45RO+ NNP cord-005453-4057qib7 1103 25 cells cell NNS cord-005453-4057qib7 1103 26 , , , cord-005453-4057qib7 1103 27 median median JJ cord-005453-4057qib7 1103 28 2 2 CD cord-005453-4057qib7 1103 29 ( ( -LRB- cord-005453-4057qib7 1103 30 range range NNP cord-005453-4057qib7 1103 31 1 1 CD cord-005453-4057qib7 1103 32 - - SYM cord-005453-4057qib7 1103 33 6 6 CD cord-005453-4057qib7 1103 34 ) ) -RRB- cord-005453-4057qib7 1103 35 , , , cord-005453-4057qib7 1103 36 containing contain VBG cord-005453-4057qib7 1103 37 a a DT cord-005453-4057qib7 1103 38 median median NN cord-005453-4057qib7 1103 39 of of IN cord-005453-4057qib7 1103 40 2.87x10 2.87x10 CD cord-005453-4057qib7 1103 41 7 7 CD cord-005453-4057qib7 1103 42 /Kg /Kg . cord-005453-4057qib7 1104 1 ( ( -LRB- cord-005453-4057qib7 1104 2 range range NN cord-005453-4057qib7 1104 3 4.8x10 4.8x10 CD cord-005453-4057qib7 1104 4 4 4 CD cord-005453-4057qib7 1104 5 -2x10 -2x10 CD cord-005453-4057qib7 1104 6 8 8 CD cord-005453-4057qib7 1104 7 /Kg /kg NN cord-005453-4057qib7 1104 8 ) ) -RRB- cord-005453-4057qib7 1104 9 , , , cord-005453-4057qib7 1104 10 CD3 CD3 NNP cord-005453-4057qib7 1104 11 + + CC cord-005453-4057qib7 1104 12 CD45RO+ CD45RO+ NNP cord-005453-4057qib7 1104 13 1.05x10 1.05x10 CD cord-005453-4057qib7 1104 14 7 7 CD cord-005453-4057qib7 1105 1 /Kg /Kg . cord-005453-4057qib7 1106 1 ( ( -LRB- cord-005453-4057qib7 1106 2 range range NN cord-005453-4057qib7 1106 3 4.8x10 4.8x10 CD cord-005453-4057qib7 1106 4 4 4 CD cord-005453-4057qib7 1106 5 -1.09x10 -1.09x10 CD cord-005453-4057qib7 1106 6 8 8 CD cord-005453-4057qib7 1106 7 /Kg /kg NN cord-005453-4057qib7 1106 8 ) ) -RRB- cord-005453-4057qib7 1106 9 and and CC cord-005453-4057qib7 1106 10 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 1106 11 cells cell NNS cord-005453-4057qib7 1106 12 5 5 CD cord-005453-4057qib7 1106 13 x10 x10 CD cord-005453-4057qib7 1106 14 2 2 CD cord-005453-4057qib7 1107 1 /Kg /Kg . cord-005453-4057qib7 1108 1 ( ( -LRB- cord-005453-4057qib7 1108 2 range range NN cord-005453-4057qib7 1108 3 0 0 CD cord-005453-4057qib7 1108 4 - - HYPH cord-005453-4057qib7 1108 5 9.8x10 9.8x10 CD cord-005453-4057qib7 1108 6 4 4 CD cord-005453-4057qib7 1108 7 /Kg /kg NN cord-005453-4057qib7 1108 8 ) ) -RRB- cord-005453-4057qib7 1108 9 . . . cord-005453-4057qib7 1109 1 All all DT cord-005453-4057qib7 1109 2 infusions infusion NNS cord-005453-4057qib7 1109 3 were be VBD cord-005453-4057qib7 1109 4 well well RB cord-005453-4057qib7 1109 5 - - HYPH cord-005453-4057qib7 1109 6 tolerated tolerate VBN cord-005453-4057qib7 1109 7 and and CC cord-005453-4057qib7 1109 8 did do VBD cord-005453-4057qib7 1109 9 not not RB cord-005453-4057qib7 1109 10 develop develop VB cord-005453-4057qib7 1109 11 or or CC cord-005453-4057qib7 1109 12 worsen worsen VB cord-005453-4057qib7 1109 13 GvHD GvHD NNP cord-005453-4057qib7 1109 14 . . . cord-005453-4057qib7 1110 1 A a DT cord-005453-4057qib7 1110 2 total total NN cord-005453-4057qib7 1110 3 of of IN cord-005453-4057qib7 1110 4 11/29 11/29 CD cord-005453-4057qib7 1110 5 episodes episode NNS cord-005453-4057qib7 1110 6 of of IN cord-005453-4057qib7 1110 7 CMV CMV NNP cord-005453-4057qib7 1110 8 / / SYM cord-005453-4057qib7 1110 9 EBV EBV NNP cord-005453-4057qib7 1110 10 viral viral JJ cord-005453-4057qib7 1110 11 reactivations reactivation NNS cord-005453-4057qib7 1110 12 decreased decrease VBD cord-005453-4057qib7 1110 13 viral viral JJ cord-005453-4057qib7 1110 14 load load NN cord-005453-4057qib7 1110 15 , , , cord-005453-4057qib7 1110 16 4/29 4/29 CD cord-005453-4057qib7 1110 17 cleared clear VBN cord-005453-4057qib7 1110 18 viral viral JJ cord-005453-4057qib7 1110 19 load load NN cord-005453-4057qib7 1110 20 and and CC cord-005453-4057qib7 1110 21 5/29 5/29 CD cord-005453-4057qib7 1110 22 showed show VBD cord-005453-4057qib7 1110 23 a a DT cord-005453-4057qib7 1110 24 clinical clinical JJ cord-005453-4057qib7 1110 25 improvement improvement NN cord-005453-4057qib7 1110 26 . . . cord-005453-4057qib7 1111 1 A a DT cord-005453-4057qib7 1111 2 total total NN cord-005453-4057qib7 1111 3 of of IN cord-005453-4057qib7 1111 4 4/5 4/5 CD cord-005453-4057qib7 1111 5 patients patient NNS cord-005453-4057qib7 1111 6 with with IN cord-005453-4057qib7 1111 7 persistent persistent JJ cord-005453-4057qib7 1111 8 lymphopenia lymphopenia NNP cord-005453-4057qib7 1111 9 there there EX cord-005453-4057qib7 1111 10 was be VBD cord-005453-4057qib7 1111 11 a a DT cord-005453-4057qib7 1111 12 slightly slightly RB cord-005453-4057qib7 1111 13 increase increase NN cord-005453-4057qib7 1111 14 in in IN cord-005453-4057qib7 1111 15 total total JJ cord-005453-4057qib7 1111 16 lymphocyte lymphocyte NN cord-005453-4057qib7 1111 17 count count NN cord-005453-4057qib7 1111 18 , , , cord-005453-4057qib7 1111 19 but but CC cord-005453-4057qib7 1111 20 not not RB cord-005453-4057qib7 1111 21 to to IN cord-005453-4057qib7 1111 22 normal normal JJ cord-005453-4057qib7 1111 23 levels level NNS cord-005453-4057qib7 1111 24 . . . cord-005453-4057qib7 1112 1 Prophylactic prophylactic JJ cord-005453-4057qib7 1112 2 DLI DLI NNP cord-005453-4057qib7 1112 3 of of IN cord-005453-4057qib7 1112 4 CD45RO+ CD45RO+ NNS cord-005453-4057qib7 1112 5 to to TO cord-005453-4057qib7 1112 6 boost boost VB cord-005453-4057qib7 1112 7 IR IR NNP cord-005453-4057qib7 1112 8 increased increase VBN cord-005453-4057qib7 1112 9 lymphocyte lymphocyte NN cord-005453-4057qib7 1112 10 count count NN cord-005453-4057qib7 1112 11 in in IN cord-005453-4057qib7 1112 12 2 2 CD cord-005453-4057qib7 1112 13 of of IN cord-005453-4057qib7 1112 14 3 3 CD cord-005453-4057qib7 1112 15 cases case NNS cord-005453-4057qib7 1112 16 . . . cord-005453-4057qib7 1113 1 None none NN cord-005453-4057qib7 1113 2 of of IN cord-005453-4057qib7 1113 3 the the DT cord-005453-4057qib7 1113 4 DLI DLI NNP cord-005453-4057qib7 1113 5 administered administer VBD cord-005453-4057qib7 1113 6 in in IN cord-005453-4057qib7 1113 7 cases case NNS cord-005453-4057qib7 1113 8 of of IN cord-005453-4057qib7 1113 9 mixed mixed JJ cord-005453-4057qib7 1113 10 chimerism chimerism NN cord-005453-4057qib7 1113 11 , , , cord-005453-4057qib7 1113 12 graft graft NN cord-005453-4057qib7 1113 13 failure failure NN cord-005453-4057qib7 1113 14 or or CC cord-005453-4057qib7 1113 15 relapse relapse NN cord-005453-4057qib7 1113 16 were be VBD cord-005453-4057qib7 1113 17 effective effective JJ cord-005453-4057qib7 1113 18 in in IN cord-005453-4057qib7 1113 19 reverting revert VBG cord-005453-4057qib7 1113 20 those those DT cord-005453-4057qib7 1113 21 situations situation NNS cord-005453-4057qib7 1113 22 . . . cord-005453-4057qib7 1114 1 Conclusions conclusion NNS cord-005453-4057qib7 1114 2 : : : cord-005453-4057qib7 1115 1 Our -PRON- PRP$ cord-005453-4057qib7 1115 2 preliminary preliminary JJ cord-005453-4057qib7 1115 3 data datum NNS cord-005453-4057qib7 1115 4 suggest suggest VBP cord-005453-4057qib7 1115 5 that that IN cord-005453-4057qib7 1115 6 infusions infusion NNS cord-005453-4057qib7 1115 7 of of IN cord-005453-4057qib7 1115 8 high high JJ cord-005453-4057qib7 1115 9 dose dose NN cord-005453-4057qib7 1115 10 CD45RO+ cd45ro+ NN cord-005453-4057qib7 1115 11 memory memory NN cord-005453-4057qib7 1115 12 T t NN cord-005453-4057qib7 1115 13 cells cell NNS cord-005453-4057qib7 1115 14 are be VBP cord-005453-4057qib7 1115 15 a a DT cord-005453-4057qib7 1115 16 safe safe JJ cord-005453-4057qib7 1115 17 adoptive adoptive JJ cord-005453-4057qib7 1115 18 immunotherapy immunotherapy NN cord-005453-4057qib7 1115 19 strategy strategy NN cord-005453-4057qib7 1115 20 . . . cord-005453-4057qib7 1116 1 Efficacy efficacy NN cord-005453-4057qib7 1116 2 has have VBZ cord-005453-4057qib7 1116 3 been be VBN cord-005453-4057qib7 1116 4 observed observe VBN cord-005453-4057qib7 1116 5 in in IN cord-005453-4057qib7 1116 6 patients patient NNS cord-005453-4057qib7 1116 7 with with IN cord-005453-4057qib7 1116 8 lymphopenia lymphopenia NNP cord-005453-4057qib7 1116 9 and and CC cord-005453-4057qib7 1116 10 CMV CMV NNP cord-005453-4057qib7 1116 11 / / SYM cord-005453-4057qib7 1116 12 EBV EBV NNP cord-005453-4057qib7 1116 13 reactivation reactivation NN cord-005453-4057qib7 1116 14 , , , cord-005453-4057qib7 1116 15 with with IN cord-005453-4057qib7 1116 16 no no DT cord-005453-4057qib7 1116 17 positive positive JJ cord-005453-4057qib7 1116 18 results result NNS cord-005453-4057qib7 1116 19 in in IN cord-005453-4057qib7 1116 20 patients patient NNS cord-005453-4057qib7 1116 21 with with IN cord-005453-4057qib7 1116 22 mixed mixed JJ cord-005453-4057qib7 1116 23 chimerism chimerism NN cord-005453-4057qib7 1116 24 , , , cord-005453-4057qib7 1116 25 graft graft NN cord-005453-4057qib7 1116 26 failure failure NN cord-005453-4057qib7 1116 27 and and CC cord-005453-4057qib7 1116 28 relapse relapse NN cord-005453-4057qib7 1116 29 . . . cord-005453-4057qib7 1117 1 However however RB cord-005453-4057qib7 1117 2 , , , cord-005453-4057qib7 1117 3 to to TO cord-005453-4057qib7 1117 4 determine determine VB cord-005453-4057qib7 1117 5 the the DT cord-005453-4057qib7 1117 6 real real JJ cord-005453-4057qib7 1117 7 efficacy efficacy NN cord-005453-4057qib7 1117 8 of of IN cord-005453-4057qib7 1117 9 this this DT cord-005453-4057qib7 1117 10 strategy strategy NN cord-005453-4057qib7 1117 11 , , , cord-005453-4057qib7 1117 12 prospective prospective JJ cord-005453-4057qib7 1117 13 studies study NNS cord-005453-4057qib7 1117 14 are be VBP cord-005453-4057qib7 1117 15 required require VBN cord-005453-4057qib7 1117 16 . . . cord-005453-4057qib7 1118 1 Disclosure disclosure NN cord-005453-4057qib7 1118 2 : : : cord-005453-4057qib7 1118 3 Nothing nothing NN cord-005453-4057qib7 1118 4 to to TO cord-005453-4057qib7 1118 5 declare declare VB cord-005453-4057qib7 1118 6 . . . cord-005453-4057qib7 1119 1 Background background NN cord-005453-4057qib7 1119 2 : : : cord-005453-4057qib7 1120 1 Increasing increase VBG cord-005453-4057qib7 1120 2 clinical clinical JJ cord-005453-4057qib7 1120 3 trials trial NNS cord-005453-4057qib7 1120 4 have have VBP cord-005453-4057qib7 1120 5 confirmed confirm VBN cord-005453-4057qib7 1120 6 that that IN cord-005453-4057qib7 1120 7 chimeric chimeric JJ cord-005453-4057qib7 1120 8 antigen antigen NN cord-005453-4057qib7 1120 9 receptor receptor NN cord-005453-4057qib7 1120 10 T t NN cord-005453-4057qib7 1120 11 cells cell NNS cord-005453-4057qib7 1120 12 ( ( -LRB- cord-005453-4057qib7 1120 13 CAR car NN cord-005453-4057qib7 1120 14 - - HYPH cord-005453-4057qib7 1120 15 T T NNP cord-005453-4057qib7 1120 16 ) ) -RRB- cord-005453-4057qib7 1120 17 targeting target VBG cord-005453-4057qib7 1120 18 CD19 CD19 NNP cord-005453-4057qib7 1120 19 antigen antigen NN cord-005453-4057qib7 1120 20 ( ( -LRB- cord-005453-4057qib7 1120 21 CAR CAR NNP cord-005453-4057qib7 1120 22 - - HYPH cord-005453-4057qib7 1120 23 T-19 T-19 NNP cord-005453-4057qib7 1120 24 ) ) -RRB- cord-005453-4057qib7 1120 25 is be VBZ cord-005453-4057qib7 1120 26 a a DT cord-005453-4057qib7 1120 27 promising promising JJ cord-005453-4057qib7 1120 28 effective effective JJ cord-005453-4057qib7 1120 29 approach approach NN cord-005453-4057qib7 1120 30 for for IN cord-005453-4057qib7 1120 31 the the DT cord-005453-4057qib7 1120 32 treatment treatment NN cord-005453-4057qib7 1120 33 of of IN cord-005453-4057qib7 1120 34 relapsed relapse VBN cord-005453-4057qib7 1120 35 / / SYM cord-005453-4057qib7 1120 36 refractory(R refractory(R NNP cord-005453-4057qib7 1120 37 / / SYM cord-005453-4057qib7 1120 38 R r NN cord-005453-4057qib7 1120 39 ) ) -RRB- cord-005453-4057qib7 1120 40 B b NN cord-005453-4057qib7 1120 41 - - HYPH cord-005453-4057qib7 1120 42 cell cell NN cord-005453-4057qib7 1120 43 lineage lineage NN cord-005453-4057qib7 1120 44 malignancies malignancy NNS cord-005453-4057qib7 1120 45 . . . cord-005453-4057qib7 1121 1 Considering consider VBG cord-005453-4057qib7 1121 2 CD19 CD19 NNP cord-005453-4057qib7 1121 3 is be VBZ cord-005453-4057qib7 1121 4 frequently frequently RB cord-005453-4057qib7 1121 5 expressed express VBN cord-005453-4057qib7 1121 6 in in IN cord-005453-4057qib7 1121 7 large large JJ cord-005453-4057qib7 1121 8 part part NN cord-005453-4057qib7 1121 9 of of IN cord-005453-4057qib7 1121 10 t(8;21 t(8;21 NNP cord-005453-4057qib7 1121 11 ) ) -RRB- cord-005453-4057qib7 1122 1 acute acute JJ cord-005453-4057qib7 1122 2 myeloid myeloid NN cord-005453-4057qib7 1122 3 leukemia leukemia NN cord-005453-4057qib7 1122 4 ( ( -LRB- cord-005453-4057qib7 1122 5 AML AML NNP cord-005453-4057qib7 1122 6 ) ) -RRB- cord-005453-4057qib7 1122 7 cells cell NNS cord-005453-4057qib7 1122 8 , , , cord-005453-4057qib7 1122 9 we -PRON- PRP cord-005453-4057qib7 1122 10 suppose suppose VBP cord-005453-4057qib7 1122 11 that that IN cord-005453-4057qib7 1122 12 CAR CAR NNP cord-005453-4057qib7 1122 13 - - HYPH cord-005453-4057qib7 1122 14 T-19 T-19 NNP cord-005453-4057qib7 1122 15 may may MD cord-005453-4057qib7 1122 16 be be VB cord-005453-4057qib7 1122 17 used use VBN cord-005453-4057qib7 1122 18 as as IN cord-005453-4057qib7 1122 19 an an DT cord-005453-4057qib7 1122 20 approach approach NN cord-005453-4057qib7 1122 21 to to IN cord-005453-4057qib7 1122 22 rescuing rescue VBG cord-005453-4057qib7 1122 23 R r NN cord-005453-4057qib7 1122 24 / / SYM cord-005453-4057qib7 1122 25 R r NN cord-005453-4057qib7 1122 26 t(8;21 t(8;21 NNP cord-005453-4057qib7 1122 27 ) ) -RRB- cord-005453-4057qib7 1123 1 AML AML NNP cord-005453-4057qib7 1123 2 patients patient NNS cord-005453-4057qib7 1123 3 . . . cord-005453-4057qib7 1124 1 Methods method NNS cord-005453-4057qib7 1124 2 : : : cord-005453-4057qib7 1125 1 Both both DT cord-005453-4057qib7 1125 2 patients patient NNS cord-005453-4057qib7 1125 3 received receive VBD cord-005453-4057qib7 1125 4 lymphodepletion lymphodepletion NN cord-005453-4057qib7 1125 5 chemotherapy chemotherapy NN cord-005453-4057qib7 1125 6 with with IN cord-005453-4057qib7 1125 7 Decitabine Decitabine NNP cord-005453-4057qib7 1125 8 20mg 20mg NNP cord-005453-4057qib7 1125 9 / / SYM cord-005453-4057qib7 1125 10 m m NN cord-005453-4057qib7 1125 11 2 2 CD cord-005453-4057qib7 1125 12 ×5d ×5d CD cord-005453-4057qib7 1125 13 , , , cord-005453-4057qib7 1125 14 Fludarabine Fludarabine NNP cord-005453-4057qib7 1125 15 30mg 30mg NNP cord-005453-4057qib7 1125 16 / / SYM cord-005453-4057qib7 1125 17 m m NN cord-005453-4057qib7 1125 18 2 2 CD cord-005453-4057qib7 1125 19 ×3d ×3d NNS cord-005453-4057qib7 1125 20 and and CC cord-005453-4057qib7 1125 21 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 1126 1 300mg 300mg NNP cord-005453-4057qib7 1126 2 / / SYM cord-005453-4057qib7 1126 3 m m NN cord-005453-4057qib7 1126 4 2 2 CD cord-005453-4057qib7 1127 1 ×3d ×3d LS cord-005453-4057qib7 1127 2 ( ( -LRB- cord-005453-4057qib7 1127 3 DAC DAC NNP cord-005453-4057qib7 1127 4 + + CC cord-005453-4057qib7 1127 5 FC FC NNP cord-005453-4057qib7 1127 6 ) ) -RRB- cord-005453-4057qib7 1127 7 . . . cord-005453-4057qib7 1128 1 Two two CD cord-005453-4057qib7 1128 2 days day NNS cord-005453-4057qib7 1128 3 after after IN cord-005453-4057qib7 1128 4 chemotherapy chemotherapy NN cord-005453-4057qib7 1128 5 , , , cord-005453-4057qib7 1128 6 autologous autologous JJ cord-005453-4057qib7 1128 7 / / SYM cord-005453-4057qib7 1128 8 allogeneic allogeneic IN cord-005453-4057qib7 1128 9 CART-19 cart-19 JJ cord-005453-4057qib7 1128 10 cells cell NNS cord-005453-4057qib7 1128 11 provided provide VBN cord-005453-4057qib7 1128 12 by by IN cord-005453-4057qib7 1128 13 the the DT cord-005453-4057qib7 1128 14 unicar unicar JJ cord-005453-4057qib7 1128 15 - - HYPH cord-005453-4057qib7 1128 16 therapy therapy NN cord-005453-4057qib7 1128 17 biomedicine biomedicine NN cord-005453-4057qib7 1128 18 technology technology NN cord-005453-4057qib7 1128 19 co.(Shanghai co.(shanghai CD cord-005453-4057qib7 1128 20 , , , cord-005453-4057qib7 1128 21 China China NNP cord-005453-4057qib7 1128 22 ) ) -RRB- cord-005453-4057qib7 1128 23 at at IN cord-005453-4057qib7 1128 24 a a DT cord-005453-4057qib7 1128 25 total total JJ cord-005453-4057qib7 1128 26 dose dose NN cord-005453-4057qib7 1128 27 of of IN cord-005453-4057qib7 1128 28 5 5 CD cord-005453-4057qib7 1128 29 - - SYM cord-005453-4057qib7 1128 30 10×10 10×10 CD cord-005453-4057qib7 1128 31 6 6 CD cord-005453-4057qib7 1128 32 cells cell NNS cord-005453-4057qib7 1128 33 per per IN cord-005453-4057qib7 1128 34 kilogram(kg kilogram(kg CD cord-005453-4057qib7 1128 35 ) ) -RRB- cord-005453-4057qib7 1128 36 were be VBD cord-005453-4057qib7 1128 37 infused infuse VBN cord-005453-4057qib7 1128 38 dose dose NN cord-005453-4057qib7 1128 39 escalation escalation NN cord-005453-4057qib7 1128 40 within within IN cord-005453-4057qib7 1128 41 2 2 CD cord-005453-4057qib7 1128 42 to to TO cord-005453-4057qib7 1128 43 3 3 CD cord-005453-4057qib7 1128 44 days day NNS cord-005453-4057qib7 1128 45 . . . cord-005453-4057qib7 1129 1 The the DT cord-005453-4057qib7 1129 2 research research NN cord-005453-4057qib7 1129 3 protocol protocol NN cord-005453-4057qib7 1129 4 was be VBD cord-005453-4057qib7 1129 5 approved approve VBN cord-005453-4057qib7 1129 6 by by IN cord-005453-4057qib7 1129 7 the the DT cord-005453-4057qib7 1129 8 institutional institutional JJ cord-005453-4057qib7 1129 9 review review NN cord-005453-4057qib7 1129 10 boards board NNS cord-005453-4057qib7 1129 11 of of IN cord-005453-4057qib7 1129 12 the the DT cord-005453-4057qib7 1129 13 first first JJ cord-005453-4057qib7 1129 14 affiliated affiliated JJ cord-005453-4057qib7 1129 15 hospital hospital NN cord-005453-4057qib7 1129 16 of of IN cord-005453-4057qib7 1129 17 Soochow Soochow NNP cord-005453-4057qib7 1129 18 University University NNP cord-005453-4057qib7 1129 19 and and CC cord-005453-4057qib7 1129 20 both both DT cord-005453-4057qib7 1129 21 patients patient NNS cord-005453-4057qib7 1129 22 gave give VBD cord-005453-4057qib7 1129 23 written write VBN cord-005453-4057qib7 1129 24 informed informed JJ cord-005453-4057qib7 1129 25 consent consent NN cord-005453-4057qib7 1129 26 . . . cord-005453-4057qib7 1130 1 Results result NNS cord-005453-4057qib7 1130 2 : : : cord-005453-4057qib7 1131 1 Both both DT cord-005453-4057qib7 1131 2 cases case NNS cord-005453-4057qib7 1131 3 responded respond VBD cord-005453-4057qib7 1131 4 well well RB cord-005453-4057qib7 1131 5 with with IN cord-005453-4057qib7 1131 6 transient transient JJ cord-005453-4057qib7 1131 7 and and CC cord-005453-4057qib7 1131 8 reversible reversible JJ cord-005453-4057qib7 1131 9 toxicities toxicity NNS cord-005453-4057qib7 1131 10 . . . cord-005453-4057qib7 1132 1 Case case NN cord-005453-4057qib7 1132 2 1 1 CD cord-005453-4057qib7 1132 3 presented present VBD cord-005453-4057qib7 1132 4 with with IN cord-005453-4057qib7 1132 5 grade grade NN cord-005453-4057qib7 1132 6 1 1 CD cord-005453-4057qib7 1132 7 cytokine cytokine NN cord-005453-4057qib7 1132 8 release release NN cord-005453-4057qib7 1132 9 syndrome syndrome NN cord-005453-4057qib7 1132 10 ( ( -LRB- cord-005453-4057qib7 1132 11 CRS CRS NNP cord-005453-4057qib7 1132 12 ) ) -RRB- cord-005453-4057qib7 1132 13 , , , cord-005453-4057qib7 1132 14 manifested manifest VBN cord-005453-4057qib7 1132 15 by by IN cord-005453-4057qib7 1132 16 intermittent intermittent JJ cord-005453-4057qib7 1132 17 fever fever NN cord-005453-4057qib7 1132 18 and and CC cord-005453-4057qib7 1132 19 chill chill NN cord-005453-4057qib7 1132 20 from from IN cord-005453-4057qib7 1132 21 day day NN cord-005453-4057qib7 1132 22 4 4 CD cord-005453-4057qib7 1132 23 after after IN cord-005453-4057qib7 1132 24 CAR car NN cord-005453-4057qib7 1132 25 - - HYPH cord-005453-4057qib7 1132 26 T-19 T-19 NNP cord-005453-4057qib7 1132 27 infusion infusion NN cord-005453-4057qib7 1132 28 for for IN cord-005453-4057qib7 1132 29 half half JJ cord-005453-4057qib7 1132 30 months month NNS cord-005453-4057qib7 1132 31 associated associate VBN cord-005453-4057qib7 1132 32 with with IN cord-005453-4057qib7 1132 33 neutropenia neutropenia NN cord-005453-4057qib7 1132 34 . . . cord-005453-4057qib7 1133 1 CAR car NN cord-005453-4057qib7 1133 2 - - HYPH cord-005453-4057qib7 1133 3 T t NN cord-005453-4057qib7 1133 4 cells cell NNS cord-005453-4057qib7 1133 5 expansion expansion NN cord-005453-4057qib7 1133 6 were be VBD cord-005453-4057qib7 1133 7 observed observe VBN cord-005453-4057qib7 1133 8 in in IN cord-005453-4057qib7 1133 9 blood blood NN cord-005453-4057qib7 1133 10 without without IN cord-005453-4057qib7 1133 11 obvious obvious JJ cord-005453-4057qib7 1133 12 increase increase NN cord-005453-4057qib7 1133 13 of of IN cord-005453-4057qib7 1133 14 cytokines cytokine NNS cord-005453-4057qib7 1133 15 . . . cord-005453-4057qib7 1134 1 After after IN cord-005453-4057qib7 1134 2 infusion infusion NN cord-005453-4057qib7 1134 3 , , , cord-005453-4057qib7 1134 4 Case case NN cord-005453-4057qib7 1134 5 1 1 CD cord-005453-4057qib7 1134 6 achieved achieve VBD cord-005453-4057qib7 1134 7 and and CC cord-005453-4057qib7 1134 8 maintained maintain VBD cord-005453-4057qib7 1134 9 molecular molecular JJ cord-005453-4057qib7 1134 10 complete complete JJ cord-005453-4057qib7 1134 11 remission remission NN cord-005453-4057qib7 1134 12 ( ( -LRB- cord-005453-4057qib7 1134 13 CR CR NNP cord-005453-4057qib7 1134 14 ) ) -RRB- cord-005453-4057qib7 1134 15 for for IN cord-005453-4057qib7 1134 16 more more JJR cord-005453-4057qib7 1134 17 than than IN cord-005453-4057qib7 1134 18 10 10 CD cord-005453-4057qib7 1134 19 months month NNS cord-005453-4057qib7 1134 20 . . . cord-005453-4057qib7 1135 1 Case case NN cord-005453-4057qib7 1135 2 2 2 CD cord-005453-4057qib7 1135 3 presented present VBN cord-005453-4057qib7 1135 4 with with IN cord-005453-4057qib7 1135 5 grade grade NN cord-005453-4057qib7 1135 6 3 3 CD cord-005453-4057qib7 1135 7 CRS CRS NNP cord-005453-4057qib7 1135 8 manifested manifest VBN cord-005453-4057qib7 1135 9 by by IN cord-005453-4057qib7 1135 10 continuous continuous JJ cord-005453-4057qib7 1135 11 high high JJ cord-005453-4057qib7 1135 12 fever fever NN cord-005453-4057qib7 1135 13 , , , cord-005453-4057qib7 1135 14 hypotension hypotension NN cord-005453-4057qib7 1135 15 and and CC cord-005453-4057qib7 1135 16 grade grade NN cord-005453-4057qib7 1135 17 1 1 CD cord-005453-4057qib7 1135 18 liver liver NN cord-005453-4057qib7 1135 19 disfunction disfunction NN cord-005453-4057qib7 1135 20 from from IN cord-005453-4057qib7 1135 21 day day NN cord-005453-4057qib7 1135 22 1 1 CD cord-005453-4057qib7 1135 23 after after IN cord-005453-4057qib7 1135 24 CAR car NN cord-005453-4057qib7 1135 25 - - HYPH cord-005453-4057qib7 1135 26 T-19 T-19 NNP cord-005453-4057qib7 1135 27 cell cell NN cord-005453-4057qib7 1135 28 infusion infusion NN cord-005453-4057qib7 1135 29 for for IN cord-005453-4057qib7 1135 30 1 1 CD cord-005453-4057qib7 1135 31 week week NN cord-005453-4057qib7 1135 32 . . . cord-005453-4057qib7 1136 1 Obvious obvious JJ cord-005453-4057qib7 1136 2 cytokines cytokine NNS cord-005453-4057qib7 1136 3 releasing release VBG cord-005453-4057qib7 1136 4 ( ( -LRB- cord-005453-4057qib7 1136 5 peak peak NNP cord-005453-4057qib7 1136 6 IL-6 IL-6 NNP cord-005453-4057qib7 1136 7 serum serum NN cord-005453-4057qib7 1136 8 concentration concentration NN cord-005453-4057qib7 1136 9 1774.5 1774.5 CD cord-005453-4057qib7 1136 10 pg pg NNP cord-005453-4057qib7 1136 11 / / SYM cord-005453-4057qib7 1136 12 ml ml NN cord-005453-4057qib7 1136 13 , , , cord-005453-4057qib7 1136 14 peak peak NNP cord-005453-4057qib7 1136 15 CRP CRP NNP cord-005453-4057qib7 1136 16 serum serum NN cord-005453-4057qib7 1136 17 concentration concentration NN cord-005453-4057qib7 1136 18 367pg 367pg NNP cord-005453-4057qib7 1136 19 / / SYM cord-005453-4057qib7 1136 20 ml ml NN cord-005453-4057qib7 1136 21 ) ) -RRB- cord-005453-4057qib7 1136 22 were be VBD cord-005453-4057qib7 1136 23 detected detect VBN cord-005453-4057qib7 1136 24 which which WDT cord-005453-4057qib7 1136 25 were be VBD cord-005453-4057qib7 1136 26 associated associate VBN cord-005453-4057qib7 1136 27 with with IN cord-005453-4057qib7 1136 28 CAR car NN cord-005453-4057qib7 1136 29 - - HYPH cord-005453-4057qib7 1136 30 T-19 T-19 NNP cord-005453-4057qib7 1136 31 cell cell NN cord-005453-4057qib7 1136 32 expansion expansion NN cord-005453-4057qib7 1136 33 in in IN cord-005453-4057qib7 1136 34 blood blood NN cord-005453-4057qib7 1136 35 and and CC cord-005453-4057qib7 1136 36 no no DT cord-005453-4057qib7 1136 37 severe severe JJ cord-005453-4057qib7 1136 38 off off JJ cord-005453-4057qib7 1136 39 - - HYPH cord-005453-4057qib7 1136 40 tumor tumor NN cord-005453-4057qib7 1136 41 effect effect NN cord-005453-4057qib7 1136 42 was be VBD cord-005453-4057qib7 1136 43 observed observe VBN cord-005453-4057qib7 1136 44 . . . cord-005453-4057qib7 1137 1 After after IN cord-005453-4057qib7 1137 2 infusion infusion NN cord-005453-4057qib7 1137 3 , , , cord-005453-4057qib7 1137 4 case case NN cord-005453-4057qib7 1137 5 2 2 CD cord-005453-4057qib7 1137 6 achieved achieve VBD cord-005453-4057qib7 1137 7 hematological hematological JJ cord-005453-4057qib7 1137 8 CR cr NN cord-005453-4057qib7 1137 9 and and CC cord-005453-4057qib7 1137 10 cytogenetic cytogenetic JJ cord-005453-4057qib7 1137 11 CR cr NN cord-005453-4057qib7 1137 12 and and CC cord-005453-4057qib7 1137 13 got get VBD cord-005453-4057qib7 1137 14 3 3 CD cord-005453-4057qib7 1137 15 months month NNS cord-005453-4057qib7 1137 16 disease disease NN cord-005453-4057qib7 1137 17 free free JJ cord-005453-4057qib7 1137 18 survival survival NN cord-005453-4057qib7 1137 19 . . . cord-005453-4057qib7 1138 1 Conclusions conclusion NNS cord-005453-4057qib7 1138 2 : : : cord-005453-4057qib7 1139 1 Our -PRON- PRP$ cord-005453-4057qib7 1139 2 report report NN cord-005453-4057qib7 1139 3 implicates implicate VBZ cord-005453-4057qib7 1139 4 that that IN cord-005453-4057qib7 1139 5 CAR CAR NNP cord-005453-4057qib7 1139 6 - - HYPH cord-005453-4057qib7 1139 7 T-19 T-19 NNP cord-005453-4057qib7 1139 8 is be VBZ cord-005453-4057qib7 1139 9 a a DT cord-005453-4057qib7 1139 10 safe safe JJ cord-005453-4057qib7 1139 11 and and CC cord-005453-4057qib7 1139 12 promising promising JJ cord-005453-4057qib7 1139 13 approach approach NN cord-005453-4057qib7 1139 14 to to IN cord-005453-4057qib7 1139 15 managing manage VBG cord-005453-4057qib7 1139 16 R r NN cord-005453-4057qib7 1139 17 / / SYM cord-005453-4057qib7 1139 18 R r NN cord-005453-4057qib7 1139 19 t(8;21)AML t(8;21)aml NN cord-005453-4057qib7 1139 20 with with IN cord-005453-4057qib7 1139 21 CD19 CD19 NNP cord-005453-4057qib7 1139 22 expression expression NN cord-005453-4057qib7 1139 23 , , , cord-005453-4057qib7 1139 24 and and CC cord-005453-4057qib7 1139 25 may may MD cord-005453-4057qib7 1139 26 provide provide VB cord-005453-4057qib7 1139 27 a a DT cord-005453-4057qib7 1139 28 salvage salvage NN cord-005453-4057qib7 1139 29 treatment treatment NN cord-005453-4057qib7 1139 30 approach approach NN cord-005453-4057qib7 1139 31 for for IN cord-005453-4057qib7 1139 32 all all DT cord-005453-4057qib7 1139 33 AML AML NNP cord-005453-4057qib7 1139 34 patients patient NNS cord-005453-4057qib7 1139 35 with with IN cord-005453-4057qib7 1139 36 CD19 CD19 NNP cord-005453-4057qib7 1139 37 expression expression NN cord-005453-4057qib7 1139 38 and and CC cord-005453-4057qib7 1139 39 benefit benefit VB cord-005453-4057qib7 1139 40 a a DT cord-005453-4057qib7 1139 41 certain certain JJ cord-005453-4057qib7 1139 42 population population NN cord-005453-4057qib7 1139 43 with with IN cord-005453-4057qib7 1139 44 AML AML NNP cord-005453-4057qib7 1139 45 besides besides IN cord-005453-4057qib7 1139 46 B b NN cord-005453-4057qib7 1139 47 - - HYPH cord-005453-4057qib7 1139 48 linage linage NN cord-005453-4057qib7 1139 49 malignancies malignancy NNS cord-005453-4057qib7 1139 50 . . . cord-005453-4057qib7 1140 1 Clinical clinical JJ cord-005453-4057qib7 1140 2 Trial Trial NNP cord-005453-4057qib7 1140 3 Registry Registry NNP cord-005453-4057qib7 1140 4 : : : cord-005453-4057qib7 1141 1 NA NA NNP cord-005453-4057qib7 1141 2 Disclosure disclosure NN cord-005453-4057qib7 1141 3 : : : cord-005453-4057qib7 1141 4 Nothing nothing NN cord-005453-4057qib7 1141 5 to to TO cord-005453-4057qib7 1141 6 declare declare VB cord-005453-4057qib7 1141 7 . . . cord-005453-4057qib7 1142 1 This this DT cord-005453-4057qib7 1142 2 work work NN cord-005453-4057qib7 1142 3 was be VBD cord-005453-4057qib7 1142 4 supported support VBN cord-005453-4057qib7 1142 5 by by IN cord-005453-4057qib7 1142 6 research research NN cord-005453-4057qib7 1142 7 grants grant NNS cord-005453-4057qib7 1142 8 from from IN cord-005453-4057qib7 1142 9 the the DT cord-005453-4057qib7 1142 10 National National NNP cord-005453-4057qib7 1142 11 Key Key NNP cord-005453-4057qib7 1142 12 R&D R&D NNP cord-005453-4057qib7 1142 13 Program Program NNP cord-005453-4057qib7 1142 14 of of IN cord-005453-4057qib7 1142 15 China China NNP cord-005453-4057qib7 1142 16 ( ( -LRB- cord-005453-4057qib7 1142 17 2016YFC0902800 2016yfc0902800 CD cord-005453-4057qib7 1142 18 ) ) -RRB- cord-005453-4057qib7 1142 19 , , , cord-005453-4057qib7 1142 20 National National NNP cord-005453-4057qib7 1142 21 natural natural JJ cord-005453-4057qib7 1142 22 science science NN cord-005453-4057qib7 1142 23 Foundation Foundation NNP cord-005453-4057qib7 1142 24 of of IN cord-005453-4057qib7 1142 25 China China NNP cord-005453-4057qib7 1142 26 ( ( -LRB- cord-005453-4057qib7 1142 27 81873443 81873443 CD cord-005453-4057qib7 1142 28 , , , cord-005453-4057qib7 1142 29 81270645 81270645 CD cord-005453-4057qib7 1142 30 , , , cord-005453-4057qib7 1142 31 81400155 81400155 CD cord-005453-4057qib7 1142 32 , , , cord-005453-4057qib7 1142 33 81500146 81500146 CD cord-005453-4057qib7 1142 34 ) ) -RRB- cord-005453-4057qib7 1143 1 Background background NN cord-005453-4057qib7 1143 2 : : : cord-005453-4057qib7 1144 1 Chimeric chimeric JJ cord-005453-4057qib7 1144 2 antigen antigen NN cord-005453-4057qib7 1144 3 receptor receptor NN cord-005453-4057qib7 1144 4 engineered engineer VBD cord-005453-4057qib7 1144 5 T T NNP cord-005453-4057qib7 1144 6 ( ( -LRB- cord-005453-4057qib7 1144 7 CAR CAR NNP cord-005453-4057qib7 1144 8 - - HYPH cord-005453-4057qib7 1144 9 T T NNP cord-005453-4057qib7 1144 10 ) ) -RRB- cord-005453-4057qib7 1144 11 cells cell NNS cord-005453-4057qib7 1144 12 have have VBP cord-005453-4057qib7 1144 13 emerged emerge VBN cord-005453-4057qib7 1144 14 as as IN cord-005453-4057qib7 1144 15 a a DT cord-005453-4057qib7 1144 16 powerful powerful JJ cord-005453-4057qib7 1144 17 cellular cellular JJ cord-005453-4057qib7 1144 18 therapy therapy NN cord-005453-4057qib7 1144 19 to to TO cord-005453-4057qib7 1144 20 treat treat VB cord-005453-4057qib7 1144 21 malignant malignant JJ cord-005453-4057qib7 1144 22 disease disease NN cord-005453-4057qib7 1144 23 , , , cord-005453-4057qib7 1144 24 which which WDT cord-005453-4057qib7 1144 25 is be VBZ cord-005453-4057qib7 1144 26 currently currently RB cord-005453-4057qib7 1144 27 revolutionizing revolutionize VBG cord-005453-4057qib7 1144 28 field field NN cord-005453-4057qib7 1144 29 of of IN cord-005453-4057qib7 1144 30 cancer cancer NN cord-005453-4057qib7 1144 31 immunotherapy immunotherapy NN cord-005453-4057qib7 1144 32 . . . cord-005453-4057qib7 1145 1 A a DT cord-005453-4057qib7 1145 2 cryopreservation cryopreservation NN cord-005453-4057qib7 1145 3 step step NN cord-005453-4057qib7 1145 4 postmanufacture postmanufacture NN cord-005453-4057qib7 1145 5 is be VBZ cord-005453-4057qib7 1145 6 not not RB cord-005453-4057qib7 1145 7 only only RB cord-005453-4057qib7 1145 8 a a DT cord-005453-4057qib7 1145 9 logistical logistical JJ cord-005453-4057qib7 1145 10 necessity necessity NN cord-005453-4057qib7 1145 11 for for IN cord-005453-4057qib7 1145 12 large large JJ cord-005453-4057qib7 1145 13 scale scale NN cord-005453-4057qib7 1145 14 cell cell NN cord-005453-4057qib7 1145 15 manufacturing manufacturing NN cord-005453-4057qib7 1145 16 processes process NNS cord-005453-4057qib7 1145 17 but but CC cord-005453-4057qib7 1145 18 also also RB cord-005453-4057qib7 1145 19 a a DT cord-005453-4057qib7 1145 20 mandatory mandatory JJ cord-005453-4057qib7 1145 21 request request NN cord-005453-4057qib7 1145 22 by by IN cord-005453-4057qib7 1145 23 regulatory regulatory JJ cord-005453-4057qib7 1145 24 authorities authority NNS cord-005453-4057qib7 1145 25 . . . cord-005453-4057qib7 1146 1 In in IN cord-005453-4057qib7 1146 2 case case NN cord-005453-4057qib7 1146 3 relapse relapse NN cord-005453-4057qib7 1146 4 after after IN cord-005453-4057qib7 1146 5 1 1 CD cord-005453-4057qib7 1146 6 st st NNP cord-005453-4057qib7 1146 7 CAR CAR NNP cord-005453-4057qib7 1146 8 - - HYPH cord-005453-4057qib7 1146 9 T T NNP cord-005453-4057qib7 1146 10 cell cell NN cord-005453-4057qib7 1146 11 transplantation transplantation NN cord-005453-4057qib7 1146 12 , , , cord-005453-4057qib7 1146 13 a a DT cord-005453-4057qib7 1146 14 second second JJ cord-005453-4057qib7 1146 15 application application NN cord-005453-4057qib7 1146 16 , , , cord-005453-4057qib7 1146 17 maybe maybe RB cord-005453-4057qib7 1146 18 at at IN cord-005453-4057qib7 1146 19 a a DT cord-005453-4057qib7 1146 20 higher high JJR cord-005453-4057qib7 1146 21 dose dose NN cord-005453-4057qib7 1146 22 constitutes constitute VBZ cord-005453-4057qib7 1146 23 a a DT cord-005453-4057qib7 1146 24 therapeutical therapeutical JJ cord-005453-4057qib7 1146 25 option option NN cord-005453-4057qib7 1146 26 . . . cord-005453-4057qib7 1147 1 However however RB cord-005453-4057qib7 1147 2 , , , cord-005453-4057qib7 1147 3 data datum NNS cord-005453-4057qib7 1147 4 concerning concern VBG cord-005453-4057qib7 1147 5 clinical clinical JJ cord-005453-4057qib7 1147 6 grade grade NN cord-005453-4057qib7 1147 7 CAR CAR NNP cord-005453-4057qib7 1147 8 - - HYPH cord-005453-4057qib7 1147 9 T t NN cord-005453-4057qib7 1147 10 cell cell NN cord-005453-4057qib7 1147 11 stability stability NN cord-005453-4057qib7 1147 12 and and CC cord-005453-4057qib7 1147 13 functionality functionality NN cord-005453-4057qib7 1147 14 after after IN cord-005453-4057qib7 1147 15 months month NNS cord-005453-4057qib7 1147 16 of of IN cord-005453-4057qib7 1147 17 cryopreservation cryopreservation NN cord-005453-4057qib7 1147 18 have have VBP cord-005453-4057qib7 1147 19 not not RB cord-005453-4057qib7 1147 20 been be VBN cord-005453-4057qib7 1147 21 released release VBN cord-005453-4057qib7 1147 22 by by IN cord-005453-4057qib7 1147 23 companies company NNS cord-005453-4057qib7 1147 24 so so RB cord-005453-4057qib7 1147 25 far far RB cord-005453-4057qib7 1147 26 . . . cord-005453-4057qib7 1148 1 To to TO cord-005453-4057qib7 1148 2 investigate investigate VB cord-005453-4057qib7 1148 3 the the DT cord-005453-4057qib7 1148 4 effect effect NN cord-005453-4057qib7 1148 5 of of IN cord-005453-4057qib7 1148 6 cryopreservation cryopreservation NN cord-005453-4057qib7 1148 7 on on IN cord-005453-4057qib7 1148 8 CAR car NN cord-005453-4057qib7 1148 9 - - HYPH cord-005453-4057qib7 1148 10 T t NN cord-005453-4057qib7 1148 11 cells cell NNS cord-005453-4057qib7 1148 12 , , , cord-005453-4057qib7 1148 13 we -PRON- PRP cord-005453-4057qib7 1148 14 performed perform VBD cord-005453-4057qib7 1148 15 this this DT cord-005453-4057qib7 1148 16 study study NN cord-005453-4057qib7 1148 17 . . . cord-005453-4057qib7 1149 1 Methods method NNS cord-005453-4057qib7 1149 2 : : : cord-005453-4057qib7 1149 3 Different different JJ cord-005453-4057qib7 1149 4 batches batch NNS cord-005453-4057qib7 1149 5 of of IN cord-005453-4057qib7 1149 6 CD19 CD19 NNP cord-005453-4057qib7 1149 7 CAR CAR NNP cord-005453-4057qib7 1149 8 - - HYPH cord-005453-4057qib7 1149 9 T t NN cord-005453-4057qib7 1149 10 cells cell NNS cord-005453-4057qib7 1149 11 were be VBD cord-005453-4057qib7 1149 12 manufactured manufacture VBN cord-005453-4057qib7 1149 13 according accord VBG cord-005453-4057qib7 1149 14 to to IN cord-005453-4057qib7 1149 15 GMP GMP NNP cord-005453-4057qib7 1149 16 requirements requirement NNS cord-005453-4057qib7 1149 17 at at IN cord-005453-4057qib7 1149 18 our -PRON- PRP$ cord-005453-4057qib7 1149 19 institution institution NN cord-005453-4057qib7 1149 20 . . . cord-005453-4057qib7 1150 1 Final final JJ cord-005453-4057qib7 1150 2 CAR CAR NNP cord-005453-4057qib7 1150 3 - - HYPH cord-005453-4057qib7 1150 4 T t NN cord-005453-4057qib7 1150 5 products product NNS cord-005453-4057qib7 1150 6 were be VBD cord-005453-4057qib7 1150 7 frozen freeze VBN cord-005453-4057qib7 1150 8 at at IN cord-005453-4057qib7 1150 9 concentrations concentration NNS cord-005453-4057qib7 1150 10 of of IN cord-005453-4057qib7 1150 11 1 1 CD cord-005453-4057qib7 1150 12 x x SYM cord-005453-4057qib7 1150 13 10 10 CD cord-005453-4057qib7 1150 14 7 7 CD cord-005453-4057qib7 1150 15 cells cell NNS cord-005453-4057qib7 1150 16 / / SYM cord-005453-4057qib7 1150 17 ml ml NN cord-005453-4057qib7 1150 18 ( ( -LRB- cord-005453-4057qib7 1150 19 high high JJ cord-005453-4057qib7 1150 20 batch batch NN cord-005453-4057qib7 1150 21 ) ) -RRB- cord-005453-4057qib7 1150 22 and and CC cord-005453-4057qib7 1150 23 2 2 CD cord-005453-4057qib7 1150 24 x x SYM cord-005453-4057qib7 1150 25 10 10 CD cord-005453-4057qib7 1150 26 6 6 CD cord-005453-4057qib7 1150 27 cells cell NNS cord-005453-4057qib7 1150 28 / / SYM cord-005453-4057qib7 1150 29 ml ml NN cord-005453-4057qib7 1150 30 ( ( -LRB- cord-005453-4057qib7 1150 31 low low JJ cord-005453-4057qib7 1150 32 batch batch NN cord-005453-4057qib7 1150 33 ) ) -RRB- cord-005453-4057qib7 1150 34 by by IN cord-005453-4057qib7 1150 35 a a DT cord-005453-4057qib7 1150 36 controlled control VBN cord-005453-4057qib7 1150 37 freezing freezing NN cord-005453-4057qib7 1150 38 process process NN cord-005453-4057qib7 1150 39 with with IN cord-005453-4057qib7 1150 40 the the DT cord-005453-4057qib7 1150 41 Biofreeze Biofreeze NNP cord-005453-4057qib7 1150 42 BV40 BV40 NNP cord-005453-4057qib7 1150 43 device device NN cord-005453-4057qib7 1150 44 and and CC cord-005453-4057qib7 1150 45 stored store VBN cord-005453-4057qib7 1150 46 in in IN cord-005453-4057qib7 1150 47 liquid liquid JJ cord-005453-4057qib7 1150 48 nitrogen nitrogen NN cord-005453-4057qib7 1150 49 tanks tank NNS cord-005453-4057qib7 1150 50 below below IN cord-005453-4057qib7 1150 51 -150 -150 NN cord-005453-4057qib7 1150 52 ° ° NN cord-005453-4057qib7 1150 53 C C NNP cord-005453-4057qib7 1150 54 until until IN cord-005453-4057qib7 1150 55 release release NN cord-005453-4057qib7 1150 56 . . . cord-005453-4057qib7 1151 1 Quality quality NN cord-005453-4057qib7 1151 2 control control NN cord-005453-4057qib7 1151 3 tests test NNS cord-005453-4057qib7 1151 4 for for IN cord-005453-4057qib7 1151 5 sterility sterility NN cord-005453-4057qib7 1151 6 , , , cord-005453-4057qib7 1151 7 endotoxin endotoxin NN cord-005453-4057qib7 1151 8 and and CC cord-005453-4057qib7 1151 9 mycoplasma mycoplasma NN cord-005453-4057qib7 1151 10 were be VBD cord-005453-4057qib7 1151 11 performed perform VBN cord-005453-4057qib7 1151 12 for for IN cord-005453-4057qib7 1151 13 each each DT cord-005453-4057qib7 1151 14 batch batch NN cord-005453-4057qib7 1151 15 according accord VBG cord-005453-4057qib7 1151 16 to to IN cord-005453-4057qib7 1151 17 European European NNP cord-005453-4057qib7 1151 18 Pharmacopoeia Pharmacopoeia NNP cord-005453-4057qib7 1151 19 and and CC cord-005453-4057qib7 1151 20 United United NNP cord-005453-4057qib7 1151 21 States States NNP cord-005453-4057qib7 1151 22 Pharmacopoeia Pharmacopoeia NNP cord-005453-4057qib7 1151 23 guidelines guideline NNS cord-005453-4057qib7 1151 24 . . . cord-005453-4057qib7 1152 1 Stability stability NN cord-005453-4057qib7 1152 2 of of IN cord-005453-4057qib7 1152 3 CD19 CD19 NNP cord-005453-4057qib7 1152 4 CAR CAR NNP cord-005453-4057qib7 1152 5 - - HYPH cord-005453-4057qib7 1152 6 T t NN cord-005453-4057qib7 1152 7 cells cell NNS cord-005453-4057qib7 1152 8 in in IN cord-005453-4057qib7 1152 9 terms term NNS cord-005453-4057qib7 1152 10 of of IN cord-005453-4057qib7 1152 11 viability viability NN cord-005453-4057qib7 1152 12 , , , cord-005453-4057qib7 1152 13 recovery recovery NN cord-005453-4057qib7 1152 14 , , , cord-005453-4057qib7 1152 15 transduction transduction NN cord-005453-4057qib7 1152 16 efficiency efficiency NN cord-005453-4057qib7 1152 17 and and CC cord-005453-4057qib7 1152 18 functional functional JJ cord-005453-4057qib7 1152 19 capacity capacity NN cord-005453-4057qib7 1152 20 were be VBD cord-005453-4057qib7 1152 21 determined determine VBN cord-005453-4057qib7 1152 22 by by IN cord-005453-4057qib7 1152 23 microscopy microscopy NNS cord-005453-4057qib7 1152 24 , , , cord-005453-4057qib7 1152 25 multi multi JJ cord-005453-4057qib7 1152 26 - - JJ cord-005453-4057qib7 1152 27 parametric parametric JJ cord-005453-4057qib7 1152 28 flow flow NN cord-005453-4057qib7 1152 29 cytometry cytometry NN cord-005453-4057qib7 1152 30 as as RB cord-005453-4057qib7 1152 31 well well RB cord-005453-4057qib7 1152 32 as as IN cord-005453-4057qib7 1152 33 chromium-51 chromium-51 NN cord-005453-4057qib7 1152 34 release release NN cord-005453-4057qib7 1152 35 tests test NNS cord-005453-4057qib7 1152 36 following follow VBG cord-005453-4057qib7 1152 37 our -PRON- PRP$ cord-005453-4057qib7 1152 38 SOPs sop NNS cord-005453-4057qib7 1152 39 . . . cord-005453-4057qib7 1153 1 Results result NNS cord-005453-4057qib7 1153 2 : : : cord-005453-4057qib7 1154 1 All all PDT cord-005453-4057qib7 1154 2 the the DT cord-005453-4057qib7 1154 3 results result NNS cord-005453-4057qib7 1154 4 of of IN cord-005453-4057qib7 1154 5 quality quality NN cord-005453-4057qib7 1154 6 controls control NNS cord-005453-4057qib7 1154 7 fully fully RB cord-005453-4057qib7 1154 8 met meet VBD cord-005453-4057qib7 1154 9 the the DT cord-005453-4057qib7 1154 10 requirements requirement NNS cord-005453-4057qib7 1154 11 of of IN cord-005453-4057qib7 1154 12 the the DT cord-005453-4057qib7 1154 13 regulatory regulatory JJ cord-005453-4057qib7 1154 14 authorities authority NNS cord-005453-4057qib7 1154 15 . . . cord-005453-4057qib7 1155 1 Stability stability NN cord-005453-4057qib7 1155 2 results result NNS cord-005453-4057qib7 1155 3 were be VBD cord-005453-4057qib7 1155 4 highly highly RB cord-005453-4057qib7 1155 5 robust robust JJ cord-005453-4057qib7 1155 6 and and CC cord-005453-4057qib7 1155 7 reproducible reproducible JJ cord-005453-4057qib7 1155 8 over over IN cord-005453-4057qib7 1155 9 time time NN cord-005453-4057qib7 1155 10 for for IN cord-005453-4057qib7 1155 11 all all PDT cord-005453-4057qib7 1155 12 our -PRON- PRP$ cord-005453-4057qib7 1155 13 GMP GMP NNP cord-005453-4057qib7 1155 14 CAR CAR NNP cord-005453-4057qib7 1155 15 - - HYPH cord-005453-4057qib7 1155 16 T t NN cord-005453-4057qib7 1155 17 batches batch NNS cord-005453-4057qib7 1155 18 . . . cord-005453-4057qib7 1156 1 Duration duration NN cord-005453-4057qib7 1156 2 of of IN cord-005453-4057qib7 1156 3 cryopreservation cryopreservation NN cord-005453-4057qib7 1156 4 ( ( -LRB- cord-005453-4057qib7 1156 5 up up IN cord-005453-4057qib7 1156 6 to to TO cord-005453-4057qib7 1156 7 90 90 CD cord-005453-4057qib7 1156 8 days day NNS cord-005453-4057qib7 1156 9 ) ) -RRB- cord-005453-4057qib7 1156 10 had have VBD cord-005453-4057qib7 1156 11 no no DT cord-005453-4057qib7 1156 12 negative negative JJ cord-005453-4057qib7 1156 13 influence influence NN cord-005453-4057qib7 1156 14 on on IN cord-005453-4057qib7 1156 15 cell cell NN cord-005453-4057qib7 1156 16 viability viability NN cord-005453-4057qib7 1156 17 , , , cord-005453-4057qib7 1156 18 recovery recovery NN cord-005453-4057qib7 1156 19 of of IN cord-005453-4057qib7 1156 20 viable viable JJ cord-005453-4057qib7 1156 21 CD19 CD19 NNP cord-005453-4057qib7 1156 22 CAR CAR NNP cord-005453-4057qib7 1156 23 - - HYPH cord-005453-4057qib7 1156 24 T t NN cord-005453-4057qib7 1156 25 cells cell NNS cord-005453-4057qib7 1156 26 and and CC cord-005453-4057qib7 1156 27 transduction transduction NN cord-005453-4057qib7 1156 28 efficiency efficiency NN cord-005453-4057qib7 1156 29 . . . cord-005453-4057qib7 1157 1 However however RB cord-005453-4057qib7 1157 2 , , , cord-005453-4057qib7 1157 3 the the DT cord-005453-4057qib7 1157 4 cell cell NN cord-005453-4057qib7 1157 5 concentration concentration NN cord-005453-4057qib7 1157 6 for for IN cord-005453-4057qib7 1157 7 cryopreservation cryopreservation NN cord-005453-4057qib7 1157 8 has have VBZ cord-005453-4057qib7 1157 9 a a DT cord-005453-4057qib7 1157 10 significant significant JJ cord-005453-4057qib7 1157 11 impact impact NN cord-005453-4057qib7 1157 12 on on IN cord-005453-4057qib7 1157 13 the the DT cord-005453-4057qib7 1157 14 post post JJ cord-005453-4057qib7 1157 15 - - JJ cord-005453-4057qib7 1157 16 thawing thawing JJ cord-005453-4057qib7 1157 17 viability viability NN cord-005453-4057qib7 1157 18 ( ( -LRB- cord-005453-4057qib7 1157 19 low low JJ cord-005453-4057qib7 1157 20 batches batch NNS cord-005453-4057qib7 1157 21 vs. vs. IN cord-005453-4057qib7 1157 22 high high JJ cord-005453-4057qib7 1157 23 batches batch NNS cord-005453-4057qib7 1157 24 : : : cord-005453-4057qib7 1157 25 96.33 96.33 CD cord-005453-4057qib7 1157 26 ± ± CD cord-005453-4057qib7 1157 27 2.17 2.17 CD cord-005453-4057qib7 1157 28 vs. vs. IN cord-005453-4057qib7 1157 29 74.87 74.87 CD cord-005453-4057qib7 1157 30 ± ± CD cord-005453-4057qib7 1157 31 8.68 8.68 CD cord-005453-4057qib7 1157 32 , , , cord-005453-4057qib7 1157 33 p p NN cord-005453-4057qib7 1157 34 < < XX cord-005453-4057qib7 1157 35 0.05 0.05 CD cord-005453-4057qib7 1157 36 ) ) -RRB- cord-005453-4057qib7 1157 37 and and CC cord-005453-4057qib7 1157 38 recovery recovery NN cord-005453-4057qib7 1157 39 ( ( -LRB- cord-005453-4057qib7 1157 40 low low JJ cord-005453-4057qib7 1157 41 batches batch NNS cord-005453-4057qib7 1157 42 vs. vs. IN cord-005453-4057qib7 1157 43 high high JJ cord-005453-4057qib7 1157 44 batches batch NNS cord-005453-4057qib7 1157 45 : : : cord-005453-4057qib7 1158 1 89.67 89.67 CD cord-005453-4057qib7 1158 2 ± ± CD cord-005453-4057qib7 1158 3 6.76 6.76 CD cord-005453-4057qib7 1158 4 vs. vs. IN cord-005453-4057qib7 1158 5 74.90 74.90 CD cord-005453-4057qib7 1158 6 ± ± CD cord-005453-4057qib7 1158 7 9.19 9.19 CD cord-005453-4057qib7 1158 8 , , , cord-005453-4057qib7 1158 9 p p NN cord-005453-4057qib7 1158 10 < < XX cord-005453-4057qib7 1158 11 0.05 0.05 CD cord-005453-4057qib7 1158 12 ) ) -RRB- cord-005453-4057qib7 1158 13 of of IN cord-005453-4057qib7 1158 14 cryopreserved cryopreserve VBN cord-005453-4057qib7 1158 15 CD19 CD19 NNP cord-005453-4057qib7 1158 16 CAR CAR NNP cord-005453-4057qib7 1158 17 - - HYPH cord-005453-4057qib7 1158 18 T t NN cord-005453-4057qib7 1158 19 cells cell NNS cord-005453-4057qib7 1158 20 , , , cord-005453-4057qib7 1158 21 but but CC cord-005453-4057qib7 1158 22 not not RB cord-005453-4057qib7 1158 23 the the DT cord-005453-4057qib7 1158 24 transduction transduction NN cord-005453-4057qib7 1158 25 efficiency efficiency NN cord-005453-4057qib7 1158 26 . . . cord-005453-4057qib7 1159 1 Moreover moreover RB cord-005453-4057qib7 1159 2 , , , cord-005453-4057qib7 1159 3 we -PRON- PRP cord-005453-4057qib7 1159 4 observed observe VBD cord-005453-4057qib7 1159 5 four four CD cord-005453-4057qib7 1159 6 transient transient JJ cord-005453-4057qib7 1159 7 side side NN cord-005453-4057qib7 1159 8 - - HYPH cord-005453-4057qib7 1159 9 effects effect NNS cord-005453-4057qib7 1159 10 of of IN cord-005453-4057qib7 1159 11 cryopreservation cryopreservation NN cord-005453-4057qib7 1159 12 on on IN cord-005453-4057qib7 1159 13 the the DT cord-005453-4057qib7 1159 14 amount amount NN cord-005453-4057qib7 1159 15 of of IN cord-005453-4057qib7 1159 16 cytokines cytokine NNS cord-005453-4057qib7 1159 17 released release VBN cord-005453-4057qib7 1159 18 by by IN cord-005453-4057qib7 1159 19 CAR car NN cord-005453-4057qib7 1159 20 - - HYPH cord-005453-4057qib7 1159 21 T t NN cord-005453-4057qib7 1159 22 cells cell NNS cord-005453-4057qib7 1159 23 , , , cord-005453-4057qib7 1159 24 the the DT cord-005453-4057qib7 1159 25 cytokine cytokine NN cord-005453-4057qib7 1159 26 release release NN cord-005453-4057qib7 1159 27 on on IN cord-005453-4057qib7 1159 28 a a DT cord-005453-4057qib7 1159 29 per per IN cord-005453-4057qib7 1159 30 - - HYPH cord-005453-4057qib7 1159 31 cell cell NN cord-005453-4057qib7 1159 32 basis basis NN cord-005453-4057qib7 1159 33 , , , cord-005453-4057qib7 1159 34 the the DT cord-005453-4057qib7 1159 35 multifunctionality multifunctionality NN cord-005453-4057qib7 1159 36 of of IN cord-005453-4057qib7 1159 37 CAR CAR NNP cord-005453-4057qib7 1159 38 - - HYPH cord-005453-4057qib7 1159 39 T t NN cord-005453-4057qib7 1159 40 cells cell NNS cord-005453-4057qib7 1159 41 and and CC cord-005453-4057qib7 1159 42 the the DT cord-005453-4057qib7 1159 43 killing killing NN cord-005453-4057qib7 1159 44 capacity capacity NN cord-005453-4057qib7 1159 45 . . . cord-005453-4057qib7 1160 1 Of of IN cord-005453-4057qib7 1160 2 note note VB cord-005453-4057qib7 1160 3 , , , cord-005453-4057qib7 1160 4 functional functional JJ cord-005453-4057qib7 1160 5 capacity capacity NN cord-005453-4057qib7 1160 6 of of IN cord-005453-4057qib7 1160 7 cryopreserved cryopreserved JJ cord-005453-4057qib7 1160 8 CAR car NN cord-005453-4057qib7 1160 9 - - HYPH cord-005453-4057qib7 1160 10 T t NN cord-005453-4057qib7 1160 11 cells cell NNS cord-005453-4057qib7 1160 12 after after IN cord-005453-4057qib7 1160 13 overnight overnight JJ cord-005453-4057qib7 1160 14 resting resting NN cord-005453-4057qib7 1160 15 was be VBD cord-005453-4057qib7 1160 16 comparable comparable JJ cord-005453-4057qib7 1160 17 or or CC cord-005453-4057qib7 1160 18 even even RB cord-005453-4057qib7 1160 19 enhanced enhance VBN cord-005453-4057qib7 1160 20 for for IN cord-005453-4057qib7 1160 21 INF INF NNP cord-005453-4057qib7 1160 22 - - HYPH cord-005453-4057qib7 1160 23 γ γ NNP cord-005453-4057qib7 1160 24 and and CC cord-005453-4057qib7 1160 25 TNF TNF NNP cord-005453-4057qib7 1160 26 - - HYPH cord-005453-4057qib7 1160 27 α α NNP cord-005453-4057qib7 1160 28 release release NN cord-005453-4057qib7 1160 29 by by IN cord-005453-4057qib7 1160 30 CD4 CD4 NNP cord-005453-4057qib7 1160 31 + + CC cord-005453-4057qib7 1161 1 and and CC cord-005453-4057qib7 1161 2 CD8 CD8 NNP cord-005453-4057qib7 1161 3 + + SYM cord-005453-4057qib7 1161 4 CD19 CD19 NNP cord-005453-4057qib7 1161 5 CAR CAR NNP cord-005453-4057qib7 1161 6 - - HYPH cord-005453-4057qib7 1161 7 T t NN cord-005453-4057qib7 1161 8 cells cell NNS cord-005453-4057qib7 1161 9 when when WRB cord-005453-4057qib7 1161 10 compared compare VBN cord-005453-4057qib7 1161 11 to to IN cord-005453-4057qib7 1161 12 fresh fresh JJ cord-005453-4057qib7 1161 13 CAR car NN cord-005453-4057qib7 1161 14 - - HYPH cord-005453-4057qib7 1161 15 T t NN cord-005453-4057qib7 1161 16 cells cell NNS cord-005453-4057qib7 1161 17 . . . cord-005453-4057qib7 1162 1 The the DT cord-005453-4057qib7 1162 2 multi multi JJ cord-005453-4057qib7 1162 3 - - NN cord-005453-4057qib7 1162 4 functionality functionality NN cord-005453-4057qib7 1162 5 of of IN cord-005453-4057qib7 1162 6 CAR car NN cord-005453-4057qib7 1162 7 - - HYPH cord-005453-4057qib7 1162 8 T t NN cord-005453-4057qib7 1162 9 cells cell NNS cord-005453-4057qib7 1162 10 could could MD cord-005453-4057qib7 1162 11 be be VB cord-005453-4057qib7 1162 12 preserved preserve VBN cord-005453-4057qib7 1162 13 . . . cord-005453-4057qib7 1163 1 Furthermore furthermore RB cord-005453-4057qib7 1163 2 , , , cord-005453-4057qib7 1163 3 the the DT cord-005453-4057qib7 1163 4 killing killing NN cord-005453-4057qib7 1163 5 capacity capacity NN cord-005453-4057qib7 1163 6 of of IN cord-005453-4057qib7 1163 7 cryopreserved cryopreserve VBN cord-005453-4057qib7 1163 8 CD19 CD19 NNP cord-005453-4057qib7 1163 9 CAR CAR NNP cord-005453-4057qib7 1163 10 - - HYPH cord-005453-4057qib7 1163 11 T t NN cord-005453-4057qib7 1163 12 cells cell NNS cord-005453-4057qib7 1163 13 after after IN cord-005453-4057qib7 1163 14 overnight overnight JJ cord-005453-4057qib7 1163 15 resting resting NN cord-005453-4057qib7 1163 16 could could MD cord-005453-4057qib7 1163 17 reach reach VB cord-005453-4057qib7 1163 18 the the DT cord-005453-4057qib7 1163 19 level level NN cord-005453-4057qib7 1163 20 of of IN cord-005453-4057qib7 1163 21 non non JJ cord-005453-4057qib7 1163 22 - - JJ cord-005453-4057qib7 1163 23 cryopreserved cryopreserved JJ cord-005453-4057qib7 1163 24 / / SYM cord-005453-4057qib7 1163 25 fresh fresh JJ cord-005453-4057qib7 1163 26 CAR car NN cord-005453-4057qib7 1163 27 - - HYPH cord-005453-4057qib7 1163 28 T t NN cord-005453-4057qib7 1163 29 cells cell NNS cord-005453-4057qib7 1163 30 . . . cord-005453-4057qib7 1164 1 Conclusions conclusion NNS cord-005453-4057qib7 1164 2 : : : cord-005453-4057qib7 1165 1 Cryopreservation cryopreservation NN cord-005453-4057qib7 1165 2 up up RB cord-005453-4057qib7 1165 3 to to TO cord-005453-4057qib7 1165 4 90 90 CD cord-005453-4057qib7 1165 5 days day NNS cord-005453-4057qib7 1165 6 has have VBZ cord-005453-4057qib7 1165 7 no no DT cord-005453-4057qib7 1165 8 harmful harmful JJ cord-005453-4057qib7 1165 9 effect effect NN cord-005453-4057qib7 1165 10 on on IN cord-005453-4057qib7 1165 11 transduction transduction NN cord-005453-4057qib7 1165 12 efficiency efficiency NN cord-005453-4057qib7 1165 13 and and CC cord-005453-4057qib7 1165 14 functionalities functionality NNS cord-005453-4057qib7 1165 15 of of IN cord-005453-4057qib7 1165 16 CAR car NN cord-005453-4057qib7 1165 17 - - HYPH cord-005453-4057qib7 1165 18 T t NN cord-005453-4057qib7 1165 19 cells cell NNS cord-005453-4057qib7 1165 20 . . . cord-005453-4057qib7 1166 1 However however RB cord-005453-4057qib7 1166 2 , , , cord-005453-4057qib7 1166 3 the the DT cord-005453-4057qib7 1166 4 cell cell NN cord-005453-4057qib7 1166 5 number number NN cord-005453-4057qib7 1166 6 per per IN cord-005453-4057qib7 1166 7 milliliter milliliter NN cord-005453-4057qib7 1166 8 freezing freeze VBG cord-005453-4057qib7 1166 9 medium medium NN cord-005453-4057qib7 1166 10 matters matter NNS cord-005453-4057qib7 1166 11 . . . cord-005453-4057qib7 1167 1 Dose dose NN cord-005453-4057qib7 1167 2 over over IN cord-005453-4057qib7 1167 3 1 1 CD cord-005453-4057qib7 1167 4 x x SYM cord-005453-4057qib7 1167 5 10 10 CD cord-005453-4057qib7 1167 6 7 7 CD cord-005453-4057qib7 1167 7 cells cell NNS cord-005453-4057qib7 1167 8 / / SYM cord-005453-4057qib7 1167 9 ml ml NNS cord-005453-4057qib7 1167 10 should should MD cord-005453-4057qib7 1167 11 be be VB cord-005453-4057qib7 1167 12 avoided avoid VBN cord-005453-4057qib7 1167 13 . . . cord-005453-4057qib7 1168 1 For for IN cord-005453-4057qib7 1168 2 the the DT cord-005453-4057qib7 1168 3 conduction conduction NN cord-005453-4057qib7 1168 4 of of IN cord-005453-4057qib7 1168 5 in in FW cord-005453-4057qib7 1168 6 vitro vitro FW cord-005453-4057qib7 1168 7 bio bio NN cord-005453-4057qib7 1168 8 - - HYPH cord-005453-4057qib7 1168 9 assays assay NNS cord-005453-4057qib7 1168 10 to to TO cord-005453-4057qib7 1168 11 determine determine VB cord-005453-4057qib7 1168 12 the the DT cord-005453-4057qib7 1168 13 function function NN cord-005453-4057qib7 1168 14 of of IN cord-005453-4057qib7 1168 15 CAR car NN cord-005453-4057qib7 1168 16 - - HYPH cord-005453-4057qib7 1168 17 T t NN cord-005453-4057qib7 1168 18 cells cell NNS cord-005453-4057qib7 1168 19 , , , cord-005453-4057qib7 1168 20 an an DT cord-005453-4057qib7 1168 21 overnight overnight JJ cord-005453-4057qib7 1168 22 resting resting NN cord-005453-4057qib7 1168 23 process process NN cord-005453-4057qib7 1168 24 could could MD cord-005453-4057qib7 1168 25 mimic mimic VB cord-005453-4057qib7 1168 26 the the DT cord-005453-4057qib7 1168 27 situation situation NN cord-005453-4057qib7 1168 28 after after IN cord-005453-4057qib7 1168 29 clinical clinical JJ cord-005453-4057qib7 1168 30 application application NN cord-005453-4057qib7 1168 31 and and CC cord-005453-4057qib7 1168 32 eliminate eliminate VB cord-005453-4057qib7 1168 33 the the DT cord-005453-4057qib7 1168 34 transient transient JJ cord-005453-4057qib7 1168 35 side side NN cord-005453-4057qib7 1168 36 - - HYPH cord-005453-4057qib7 1168 37 effects effect NNS cord-005453-4057qib7 1168 38 of of IN cord-005453-4057qib7 1168 39 cryopreservation cryopreservation NN cord-005453-4057qib7 1168 40 to to TO cord-005453-4057qib7 1168 41 fully fully RB cord-005453-4057qib7 1168 42 regain regain VB cord-005453-4057qib7 1168 43 the the DT cord-005453-4057qib7 1168 44 functional functional JJ cord-005453-4057qib7 1168 45 potency potency NN cord-005453-4057qib7 1168 46 of of IN cord-005453-4057qib7 1168 47 CAR car NN cord-005453-4057qib7 1168 48 - - HYPH cord-005453-4057qib7 1168 49 T t NN cord-005453-4057qib7 1168 50 cells cell NNS cord-005453-4057qib7 1168 51 . . . cord-005453-4057qib7 1169 1 Disclosure disclosure NN cord-005453-4057qib7 1169 2 : : : cord-005453-4057qib7 1169 3 Nothing nothing NN cord-005453-4057qib7 1169 4 to to TO cord-005453-4057qib7 1169 5 declare declare VB cord-005453-4057qib7 1169 6 Background background NN cord-005453-4057qib7 1169 7 : : : cord-005453-4057qib7 1169 8 DC DC NNP cord-005453-4057qib7 1169 9 and and CC cord-005453-4057qib7 1169 10 specific specific JJ cord-005453-4057qib7 1169 11 T t NN cord-005453-4057qib7 1169 12 - - HYPH cord-005453-4057qib7 1169 13 cells cell NNS cord-005453-4057qib7 1169 14 are be VBP cord-005453-4057qib7 1169 15 important important JJ cord-005453-4057qib7 1169 16 mediators mediator NNS cord-005453-4057qib7 1169 17 of of IN cord-005453-4057qib7 1169 18 CTL CTL NNP cord-005453-4057qib7 1169 19 - - HYPH cord-005453-4057qib7 1169 20 responses response NNS cord-005453-4057qib7 1169 21 . . . cord-005453-4057qib7 1170 1 We -PRON- PRP cord-005453-4057qib7 1170 2 could could MD cord-005453-4057qib7 1170 3 already already RB cord-005453-4057qib7 1170 4 show show VB cord-005453-4057qib7 1170 5 that that IN cord-005453-4057qib7 1170 6 allogeneic allogeneic NN cord-005453-4057qib7 1170 7 donor donor NN cord-005453-4057qib7 1170 8 - - HYPH cord-005453-4057qib7 1170 9 or or CC cord-005453-4057qib7 1170 10 autologous autologous JJ cord-005453-4057qib7 1170 11 T t NN cord-005453-4057qib7 1170 12 - - HYPH cord-005453-4057qib7 1170 13 cells cell NNS cord-005453-4057qib7 1170 14 obtained obtain VBN cord-005453-4057qib7 1170 15 from from IN cord-005453-4057qib7 1170 16 AMLpatients amlpatient NNS cord-005453-4057qib7 1170 17 can can MD cord-005453-4057qib7 1170 18 be be VB cord-005453-4057qib7 1170 19 stimulated stimulate VBN cord-005453-4057qib7 1170 20 by by IN cord-005453-4057qib7 1170 21 DC DC NNP cord-005453-4057qib7 1170 22 leu leu NNP cord-005453-4057qib7 1170 23 , , , cord-005453-4057qib7 1170 24 resulting result VBG cord-005453-4057qib7 1170 25 in in IN cord-005453-4057qib7 1170 26 a a DT cord-005453-4057qib7 1170 27 very very RB cord-005453-4057qib7 1170 28 efficient efficient JJ cord-005453-4057qib7 1170 29 lysis lysis NN cord-005453-4057qib7 1170 30 of of IN cord-005453-4057qib7 1170 31 naive naive JJ cord-005453-4057qib7 1170 32 blasts blast NNS cord-005453-4057qib7 1170 33 . . . cord-005453-4057qib7 1171 1 Methods method NNS cord-005453-4057qib7 1171 2 : : : cord-005453-4057qib7 1171 3 Chemokine Chemokine NNP cord-005453-4057qib7 1171 4 - - HYPH cord-005453-4057qib7 1171 5 release release NN cord-005453-4057qib7 1171 6 ( ( -LRB- cord-005453-4057qib7 1171 7 CXCL8 CXCL8 NNP cord-005453-4057qib7 1171 8 , , , cord-005453-4057qib7 1171 9 -9 -9 NNP cord-005453-4057qib7 1171 10 , , , cord-005453-4057qib7 1171 11 -10 -10 NNP cord-005453-4057qib7 1171 12 , , , cord-005453-4057qib7 1171 13 CCL2 CCL2 NNP cord-005453-4057qib7 1171 14 , , , cord-005453-4057qib7 1171 15 -5 -5 NNP cord-005453-4057qib7 1171 16 , , , cord-005453-4057qib7 1171 17 and and CC cord-005453-4057qib7 1171 18 IL-12 IL-12 NNP cord-005453-4057qib7 1171 19 ) ) -RRB- cord-005453-4057qib7 1171 20 was be VBD cord-005453-4057qib7 1171 21 analysed analyse VBN cord-005453-4057qib7 1171 22 by by IN cord-005453-4057qib7 1171 23 cytometric cytometric NNP cord-005453-4057qib7 1171 24 bead bead NN cord-005453-4057qib7 1171 25 array array NN cord-005453-4057qib7 1171 26 in in IN cord-005453-4057qib7 1171 27 serum serum NN cord-005453-4057qib7 1171 28 of of IN cord-005453-4057qib7 1171 29 AML AML NNP cord-005453-4057qib7 1171 30 / / SYM cord-005453-4057qib7 1171 31 MDS MDS NNP cord-005453-4057qib7 1171 32 - - HYPH cord-005453-4057qib7 1171 33 pts pts NNP cord-005453-4057qib7 1171 34 as as RB cord-005453-4057qib7 1171 35 well well RB cord-005453-4057qib7 1171 36 as as IN cord-005453-4057qib7 1171 37 in in IN cord-005453-4057qib7 1171 38 supernatants supernatant NNS cord-005453-4057qib7 1171 39 from from IN cord-005453-4057qib7 1171 40 5 5 CD cord-005453-4057qib7 1171 41 different different JJ cord-005453-4057qib7 1171 42 DC DC NNP cord-005453-4057qib7 1171 43 - - HYPH cord-005453-4057qib7 1171 44 generating generate VBG cord-005453-4057qib7 1171 45 - - HYPH cord-005453-4057qib7 1171 46 methods method NNS cord-005453-4057qib7 1171 47 and and CC cord-005453-4057qib7 1171 48 correlated correlate VBN cord-005453-4057qib7 1171 49 with with IN cord-005453-4057qib7 1171 50 pts pts NN cord-005453-4057qib7 1171 51 ' ' POS cord-005453-4057qib7 1171 52 clinical clinical JJ cord-005453-4057qib7 1171 53 course course NN cord-005453-4057qib7 1171 54 , , , cord-005453-4057qib7 1171 55 DC DC NNP cord-005453-4057qib7 1171 56 - - : cord-005453-4057qib7 1171 57 and and CC cord-005453-4057qib7 1171 58 T t NN cord-005453-4057qib7 1171 59 - - HYPH cord-005453-4057qib7 1171 60 cell cell NN cord-005453-4057qib7 1171 61 - - HYPH cord-005453-4057qib7 1171 62 interactions interaction NNS cord-005453-4057qib7 1171 63 as as RB cord-005453-4057qib7 1171 64 well well RB cord-005453-4057qib7 1171 65 as as IN cord-005453-4057qib7 1171 66 specific specific JJ cord-005453-4057qib7 1171 67 T t NN cord-005453-4057qib7 1171 68 - - HYPH cord-005453-4057qib7 1171 69 cell cell NN cord-005453-4057qib7 1171 70 - - HYPH cord-005453-4057qib7 1171 71 reactions reaction NNS cord-005453-4057qib7 1171 72 . . . cord-005453-4057qib7 1172 1 The the DT cord-005453-4057qib7 1172 2 lytic lytic JJ cord-005453-4057qib7 1172 3 activity activity NN cord-005453-4057qib7 1172 4 of of IN cord-005453-4057qib7 1172 5 DCleu DCleu NNP cord-005453-4057qib7 1172 6 / / SYM cord-005453-4057qib7 1172 7 blast blast NN cord-005453-4057qib7 1172 8 -stimulated -stimulated NNP cord-005453-4057qib7 1172 9 T T NNP cord-005453-4057qib7 1172 10 - - HYPH cord-005453-4057qib7 1172 11 cells cell NNS cord-005453-4057qib7 1172 12 in in IN cord-005453-4057qib7 1172 13 MLC MLC NNP cord-005453-4057qib7 1172 14 against against IN cord-005453-4057qib7 1172 15 naive naive JJ cord-005453-4057qib7 1172 16 blasts blast NNS cord-005453-4057qib7 1172 17 was be VBD cord-005453-4057qib7 1172 18 quantified quantify VBN cord-005453-4057qib7 1172 19 in in IN cord-005453-4057qib7 1172 20 a a DT cord-005453-4057qib7 1172 21 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1172 22 assay assay NN cord-005453-4057qib7 1172 23 . . . cord-005453-4057qib7 1173 1 Results result NNS cord-005453-4057qib7 1173 2 : : : cord-005453-4057qib7 1174 1 Minimal minimal JJ cord-005453-4057qib7 1174 2 differences difference NNS cord-005453-4057qib7 1174 3 in in IN cord-005453-4057qib7 1174 4 median median JJ cord-005453-4057qib7 1174 5 chemokine chemokine NN cord-005453-4057qib7 1174 6 - - HYPH cord-005453-4057qib7 1174 7 levels level NNS cord-005453-4057qib7 1174 8 in in IN cord-005453-4057qib7 1174 9 pts pts NN cord-005453-4057qib7 1174 10 ' ' POS cord-005453-4057qib7 1174 11 serum serum NN cord-005453-4057qib7 1174 12 subdivided subdivide VBN cord-005453-4057qib7 1174 13 in in IN cord-005453-4057qib7 1174 14 subtypes subtype NNS cord-005453-4057qib7 1174 15 were be VBD cord-005453-4057qib7 1174 16 seen see VBN cord-005453-4057qib7 1174 17 , , , cord-005453-4057qib7 1174 18 but but CC cord-005453-4057qib7 1174 19 higher high JJR cord-005453-4057qib7 1174 20 release release NN cord-005453-4057qib7 1174 21 of of IN cord-005453-4057qib7 1174 22 CXCL8 cxcl8 NN cord-005453-4057qib7 1174 23 , , , cord-005453-4057qib7 1174 24 -9 -9 NNP cord-005453-4057qib7 1174 25 , , , cord-005453-4057qib7 1174 26 -10 -10 NN cord-005453-4057qib7 1174 27 and and CC cord-005453-4057qib7 1174 28 lower low JJR cord-005453-4057qib7 1174 29 release release NN cord-005453-4057qib7 1174 30 of of IN cord-005453-4057qib7 1174 31 CCL2 CCL2 NNP cord-005453-4057qib7 1174 32 and and CC cord-005453-4057qib7 1174 33 -5 -5 NNP cord-005453-4057qib7 1175 1 tendentially tendentially RB cord-005453-4057qib7 1175 2 correlated correlate VBD cord-005453-4057qib7 1175 3 with with IN cord-005453-4057qib7 1175 4 more more RBR cord-005453-4057qib7 1175 5 favourable favourable JJ cord-005453-4057qib7 1175 6 subtypes subtype NNS cord-005453-4057qib7 1175 7 ( ( -LRB- cord-005453-4057qib7 1175 8 < < XX cord-005453-4057qib7 1175 9 50 50 CD cord-005453-4057qib7 1175 10 years year NNS cord-005453-4057qib7 1175 11 of of IN cord-005453-4057qib7 1175 12 age age NN cord-005453-4057qib7 1175 13 , , , cord-005453-4057qib7 1175 14 < < XX cord-005453-4057qib7 1175 15 80 80 CD cord-005453-4057qib7 1175 16 % % NN cord-005453-4057qib7 1175 17 blasts blast NNS cord-005453-4057qib7 1175 18 in in IN cord-005453-4057qib7 1175 19 PB PB NNP cord-005453-4057qib7 1175 20 ) ) -RRB- cord-005453-4057qib7 1175 21 . . . cord-005453-4057qib7 1176 1 In in IN cord-005453-4057qib7 1176 2 persisting persist VBG cord-005453-4057qib7 1176 3 disease disease NN cord-005453-4057qib7 1176 4 , , , cord-005453-4057qib7 1176 5 a a DT cord-005453-4057qib7 1176 6 higher high JJR cord-005453-4057qib7 1176 7 serum serum NN cord-005453-4057qib7 1176 8 - - HYPH cord-005453-4057qib7 1176 9 release release NN cord-005453-4057qib7 1176 10 of of IN cord-005453-4057qib7 1176 11 CCL5 CCL5 NNP cord-005453-4057qib7 1176 12 and and CC cord-005453-4057qib7 1176 13 at at IN cord-005453-4057qib7 1176 14 relapse relapse NN cord-005453-4057qib7 1176 15 a a DT cord-005453-4057qib7 1176 16 significantly significantly RB cord-005453-4057qib7 1176 17 higher high JJR cord-005453-4057qib7 1176 18 CCL2-release CCL2-release NNP cord-005453-4057qib7 1176 19 were be VBD cord-005453-4057qib7 1176 20 found find VBN cord-005453-4057qib7 1176 21 compared compare VBN cord-005453-4057qib7 1176 22 to to IN cord-005453-4057qib7 1176 23 first first JJ cord-005453-4057qib7 1176 24 diagnosis diagnosis NN cord-005453-4057qib7 1176 25 -pointing -pointe VBG cord-005453-4057qib7 1176 26 to to IN cord-005453-4057qib7 1176 27 a a DT cord-005453-4057qib7 1176 28 change change NN cord-005453-4057qib7 1176 29 of of IN cord-005453-4057qib7 1176 30 ' ' `` cord-005453-4057qib7 1176 31 disease disease NN cord-005453-4057qib7 1176 32 activity activity NN cord-005453-4057qib7 1176 33 ' ' '' cord-005453-4057qib7 1176 34 on on IN cord-005453-4057qib7 1176 35 a a DT cord-005453-4057qib7 1176 36 chemokine chemokine NN cord-005453-4057qib7 1176 37 level level NN cord-005453-4057qib7 1176 38 . . . cord-005453-4057qib7 1177 1 Whereas whereas IN cord-005453-4057qib7 1177 2 chemokine chemokine NN cord-005453-4057qib7 1177 3 - - HYPH cord-005453-4057qib7 1177 4 levels level NNS cord-005453-4057qib7 1177 5 in in IN cord-005453-4057qib7 1177 6 DC DC NNP cord-005453-4057qib7 1177 7 - - HYPH cord-005453-4057qib7 1177 8 culture culture NN cord-005453-4057qib7 1177 9 supernatants supernatant NNS cord-005453-4057qib7 1177 10 compared compare VBN cord-005453-4057qib7 1177 11 to to IN cord-005453-4057qib7 1177 12 serum serum NN cord-005453-4057qib7 1177 13 were be VBD cord-005453-4057qib7 1177 14 variable variable JJ cord-005453-4057qib7 1177 15 , , , cord-005453-4057qib7 1177 16 clear clear JJ cord-005453-4057qib7 1177 17 correlations correlation NNS cord-005453-4057qib7 1177 18 with with IN cord-005453-4057qib7 1177 19 lateron lateron RB cord-005453-4057qib7 1177 20 ( ( -LRB- cord-005453-4057qib7 1177 21 after after IN cord-005453-4057qib7 1177 22 stimulating stimulate VBG cord-005453-4057qib7 1177 23 T t NN cord-005453-4057qib7 1177 24 - - HYPH cord-005453-4057qib7 1177 25 cells cell NNS cord-005453-4057qib7 1177 26 with with IN cord-005453-4057qib7 1177 27 DCleu DCleu NNP cord-005453-4057qib7 1177 28 in in IN cord-005453-4057qib7 1177 29 MLC MLC NNP cord-005453-4057qib7 1177 30 ) ) -RRB- cord-005453-4057qib7 1177 31 improved improve VBD cord-005453-4057qib7 1177 32 antileukemic antileukemic NNP cord-005453-4057qib7 1177 33 T t NN cord-005453-4057qib7 1177 34 - - HYPH cord-005453-4057qib7 1177 35 cell cell NN cord-005453-4057qib7 1177 36 activity activity NN cord-005453-4057qib7 1177 37 were be VBD cord-005453-4057qib7 1177 38 seen see VBN cord-005453-4057qib7 1177 39 : : : cord-005453-4057qib7 1177 40 higher high JJR cord-005453-4057qib7 1177 41 values value NNS cord-005453-4057qib7 1177 42 of of IN cord-005453-4057qib7 1177 43 all all DT cord-005453-4057qib7 1177 44 chemokines chemokine NNS cord-005453-4057qib7 1177 45 in in IN cord-005453-4057qib7 1177 46 DC DC NNP cord-005453-4057qib7 1177 47 - - HYPH cord-005453-4057qib7 1177 48 culture culture NN cord-005453-4057qib7 1177 49 supernatants supernatant NNS cord-005453-4057qib7 1177 50 always always RB cord-005453-4057qib7 1177 51 correlated correlate VBD cord-005453-4057qib7 1177 52 with with IN cord-005453-4057qib7 1177 53 improved improved JJ cord-005453-4057qib7 1177 54 T T NNP cord-005453-4057qib7 1177 55 - - HYPH cord-005453-4057qib7 1177 56 cells cell NNS cord-005453-4057qib7 1177 57 ' ' POS cord-005453-4057qib7 1177 58 antileukemic antileukemic NN cord-005453-4057qib7 1177 59 activity activity NN cord-005453-4057qib7 1177 60 ( ( -LRB- cord-005453-4057qib7 1177 61 compared compare VBN cord-005453-4057qib7 1177 62 to to IN cord-005453-4057qib7 1177 63 stimulation stimulation NN cord-005453-4057qib7 1177 64 with with IN cord-005453-4057qib7 1177 65 blast blast NN cord-005453-4057qib7 1177 66 - - HYPH cord-005453-4057qib7 1177 67 containing contain VBG cord-005453-4057qib7 1177 68 MNC MNC NNP cord-005453-4057qib7 1177 69 as as IN cord-005453-4057qib7 1177 70 control control NN cord-005453-4057qib7 1177 71 ) ) -RRB- cord-005453-4057qib7 1178 1 -whereas -whereas RB cord-005453-4057qib7 1179 1 with with IN cord-005453-4057qib7 1179 2 respect respect NN cord-005453-4057qib7 1179 3 to to IN cord-005453-4057qib7 1179 4 the the DT cord-005453-4057qib7 1179 5 corresponding correspond VBG cord-005453-4057qib7 1179 6 serum serum NN cord-005453-4057qib7 1179 7 values value NNS cord-005453-4057qib7 1179 8 higher high JJR cord-005453-4057qib7 1179 9 release release NN cord-005453-4057qib7 1179 10 of of IN cord-005453-4057qib7 1179 11 CXCL8 cxcl8 NN cord-005453-4057qib7 1179 12 , , , cord-005453-4057qib7 1179 13 -9 -9 NNP cord-005453-4057qib7 1179 14 , , , cord-005453-4057qib7 1179 15 and and CC cord-005453-4057qib7 1179 16 -10 -10 NN cord-005453-4057qib7 1180 1 but but CC cord-005453-4057qib7 1180 2 lower low JJR cord-005453-4057qib7 1180 3 values value NNS cord-005453-4057qib7 1180 4 of of IN cord-005453-4057qib7 1180 5 CCL5 CCL5 NNP cord-005453-4057qib7 1180 6 and and CC cord-005453-4057qib7 1181 1 -2 -2 NNP cord-005453-4057qib7 1181 2 correlated correlate VBN cord-005453-4057qib7 1181 3 with with IN cord-005453-4057qib7 1181 4 higher high JJR cord-005453-4057qib7 1181 5 probabilities probability NNS cord-005453-4057qib7 1181 6 to to TO cord-005453-4057qib7 1181 7 improve improve VB cord-005453-4057qib7 1181 8 antileukemic antileukemic JJ cord-005453-4057qib7 1181 9 activity activity NN cord-005453-4057qib7 1181 10 of of IN cord-005453-4057qib7 1181 11 DCleu DCleu NNP cord-005453-4057qib7 1181 12 - - HYPH cord-005453-4057qib7 1181 13 stimulated stimulate VBN cord-005453-4057qib7 1181 14 ( ( -LRB- cord-005453-4057qib7 1181 15 vs. vs. FW cord-005453-4057qib7 1181 16 blaststimulated blaststimulated JJ cord-005453-4057qib7 1181 17 ) ) -RRB- cord-005453-4057qib7 1181 18 T t NN cord-005453-4057qib7 1181 19 - - HYPH cord-005453-4057qib7 1181 20 cells cell NNS cord-005453-4057qib7 1181 21 . . . cord-005453-4057qib7 1182 1 Predictive predictive JJ cord-005453-4057qib7 1182 2 significant significant JJ cord-005453-4057qib7 1182 3 cut cut VBN cord-005453-4057qib7 1182 4 - - HYPH cord-005453-4057qib7 1182 5 off off RP cord-005453-4057qib7 1182 6 - - HYPH cord-005453-4057qib7 1182 7 values value NNS cord-005453-4057qib7 1182 8 could could MD cord-005453-4057qib7 1182 9 be be VB cord-005453-4057qib7 1182 10 evaluated evaluate VBN cord-005453-4057qib7 1182 11 separating separate VBG cord-005453-4057qib7 1182 12 the the DT cord-005453-4057qib7 1182 13 groups group NNS cord-005453-4057qib7 1182 14 compared compare VBN cord-005453-4057qib7 1182 15 . . . cord-005453-4057qib7 1183 1 Moreover moreover RB cord-005453-4057qib7 1183 2 , , , cord-005453-4057qib7 1183 3 correlations correlation NNS cord-005453-4057qib7 1183 4 with with IN cord-005453-4057qib7 1183 5 lateron lateron RB cord-005453-4057qib7 1183 6 achieved achieve VBN cord-005453-4057qib7 1183 7 response response NN cord-005453-4057qib7 1183 8 to to IN cord-005453-4057qib7 1183 9 immunotherapy immunotherapy NN cord-005453-4057qib7 1183 10 and and CC cord-005453-4057qib7 1183 11 occurrence occurrence NN cord-005453-4057qib7 1183 12 of of IN cord-005453-4057qib7 1183 13 GVHD GVHD NNP cord-005453-4057qib7 1183 14 were be VBD cord-005453-4057qib7 1183 15 seen see VBN cord-005453-4057qib7 1183 16 : : : cord-005453-4057qib7 1183 17 Higher high JJR cord-005453-4057qib7 1183 18 serum serum NN cord-005453-4057qib7 1183 19 values value NNS cord-005453-4057qib7 1183 20 of of IN cord-005453-4057qib7 1183 21 CXCL8 cxcl8 NN cord-005453-4057qib7 1183 22 , , , cord-005453-4057qib7 1183 23 -9 -9 NNP cord-005453-4057qib7 1183 24 , , , cord-005453-4057qib7 1183 25 -10 -10 NNP cord-005453-4057qib7 1183 26 and and CC cord-005453-4057qib7 1183 27 CCL2 CCL2 NNP cord-005453-4057qib7 1183 28 and and CC cord-005453-4057qib7 1183 29 lower low JJR cord-005453-4057qib7 1183 30 values value NNS cord-005453-4057qib7 1183 31 of of IN cord-005453-4057qib7 1183 32 CCL5 CCL5 NNP cord-005453-4057qib7 1183 33 correlated correlate VBN cord-005453-4057qib7 1183 34 with with IN cord-005453-4057qib7 1183 35 achieved achieve VBN cord-005453-4057qib7 1183 36 response response NN cord-005453-4057qib7 1183 37 to to IN cord-005453-4057qib7 1183 38 immunotherapy immunotherapy NN cord-005453-4057qib7 1183 39 . . . cord-005453-4057qib7 1184 1 Predictive predictive JJ cord-005453-4057qib7 1184 2 cut cut VBN cord-005453-4057qib7 1184 3 - - HYPH cord-005453-4057qib7 1184 4 off off RP cord-005453-4057qib7 1184 5 - - HYPH cord-005453-4057qib7 1184 6 values value NNS cord-005453-4057qib7 1184 7 could could MD cord-005453-4057qib7 1184 8 be be VB cord-005453-4057qib7 1184 9 evaluated evaluate VBN cord-005453-4057qib7 1184 10 separating separate VBG cord-005453-4057qib7 1184 11 the the DT cord-005453-4057qib7 1184 12 groups group NNS cord-005453-4057qib7 1184 13 compared compare VBN cord-005453-4057qib7 1184 14 in in RP cord-005453-4057qib7 1184 15 ' ' `` cord-005453-4057qib7 1184 16 responders responder NNS cord-005453-4057qib7 1184 17 ' ' POS cord-005453-4057qib7 1184 18 and and CC cord-005453-4057qib7 1184 19 ' ' `` cord-005453-4057qib7 1184 20 non non NNS cord-005453-4057qib7 1184 21 - - NNS cord-005453-4057qib7 1184 22 responders responder NNS cord-005453-4057qib7 1184 23 ' ' '' cord-005453-4057qib7 1184 24 . . . cord-005453-4057qib7 1185 1 Higher high JJR cord-005453-4057qib7 1185 2 levels level NNS cord-005453-4057qib7 1185 3 of of IN cord-005453-4057qib7 1185 4 CCL2 CCL2 NNP cord-005453-4057qib7 1185 5 and and CC cord-005453-4057qib7 1185 6 -5 -5 NNP cord-005453-4057qib7 1185 7 but but CC cord-005453-4057qib7 1185 8 lower low JJR cord-005453-4057qib7 1185 9 levels level NNS cord-005453-4057qib7 1185 10 of of IN cord-005453-4057qib7 1185 11 CXCL8 cxcl8 NN cord-005453-4057qib7 1185 12 , , , cord-005453-4057qib7 1185 13 -9 -9 NNP cord-005453-4057qib7 1185 14 , , , cord-005453-4057qib7 1185 15 -10 -10 NNP cord-005453-4057qib7 1185 16 correlated correlate VBN cord-005453-4057qib7 1185 17 with with IN cord-005453-4057qib7 1185 18 occurrence occurrence NN cord-005453-4057qib7 1185 19 of of IN cord-005453-4057qib7 1185 20 GVHD GVHD NNP cord-005453-4057qib7 1185 21 . . . cord-005453-4057qib7 1186 1 Conclusions conclusion NNS cord-005453-4057qib7 1186 2 : : : cord-005453-4057qib7 1187 1 We -PRON- PRP cord-005453-4057qib7 1187 2 conclude conclude VBP cord-005453-4057qib7 1187 3 , , , cord-005453-4057qib7 1187 4 that that IN cord-005453-4057qib7 1187 5 in in IN cord-005453-4057qib7 1187 6 AML AML NNP cord-005453-4057qib7 1187 7 - - HYPH cord-005453-4057qib7 1187 8 pts pts NNP cord-005453-4057qib7 1187 9 ' ' POS cord-005453-4057qib7 1187 10 serum serum NN cord-005453-4057qib7 1187 11 higher high JJR cord-005453-4057qib7 1187 12 values value NNS cord-005453-4057qib7 1187 13 of of IN cord-005453-4057qib7 1187 14 CXCL8 cxcl8 NN cord-005453-4057qib7 1187 15 , , , cord-005453-4057qib7 1187 16 -9 -9 NNP cord-005453-4057qib7 1187 17 , , , cord-005453-4057qib7 1187 18 -10 -10 NN cord-005453-4057qib7 1187 19 and and CC cord-005453-4057qib7 1187 20 lower low JJR cord-005453-4057qib7 1187 21 values value NNS cord-005453-4057qib7 1187 22 of of IN cord-005453-4057qib7 1187 23 CCL5 CCL5 NNP cord-005453-4057qib7 1187 24 and and CC cord-005453-4057qib7 1187 25 in in IN cord-005453-4057qib7 1187 26 part part NN cord-005453-4057qib7 1187 27 of of IN cord-005453-4057qib7 1187 28 CCL2 CCL2 NNP cord-005453-4057qib7 1187 29 correlate correlate VBP cord-005453-4057qib7 1187 30 with with IN cord-005453-4057qib7 1187 31 more more RBR cord-005453-4057qib7 1187 32 favorable favorable JJ cord-005453-4057qib7 1187 33 subtypes subtype NNS cord-005453-4057qib7 1187 34 and and CC cord-005453-4057qib7 1187 35 improved improve VBN cord-005453-4057qib7 1187 36 antitumor'-reactive antitumor'-reactive JJ cord-005453-4057qib7 1187 37 function function NN cord-005453-4057qib7 1187 38 . . . cord-005453-4057qib7 1188 1 Since since IN cord-005453-4057qib7 1188 2 in in IN cord-005453-4057qib7 1188 3 DCculture DCculture NNP cord-005453-4057qib7 1188 4 supernatants supernatant NNS cord-005453-4057qib7 1188 5 higher high JJR cord-005453-4057qib7 1188 6 values value NNS cord-005453-4057qib7 1188 7 of of IN cord-005453-4057qib7 1188 8 all all DT cord-005453-4057qib7 1188 9 chemokines chemokine NNS cord-005453-4057qib7 1188 10 correlated correlate VBN cord-005453-4057qib7 1188 11 with with IN cord-005453-4057qib7 1188 12 improved improve VBN cord-005453-4057qib7 1188 13 antileukemic antileukemic NNP cord-005453-4057qib7 1188 14 T t NN cord-005453-4057qib7 1188 15 - - HYPH cord-005453-4057qib7 1188 16 cell cell NN cord-005453-4057qib7 1188 17 reactivity reactivity NN cord-005453-4057qib7 1188 18 we -PRON- PRP cord-005453-4057qib7 1188 19 conclude conclude VBP cord-005453-4057qib7 1188 20 a a DT cord-005453-4057qib7 1188 21 change change NN cord-005453-4057qib7 1188 22 of of IN cord-005453-4057qib7 1188 23 functionality functionality NN cord-005453-4057qib7 1188 24 of of IN cord-005453-4057qib7 1188 25 CCL5 CCL5 NNP cord-005453-4057qib7 1188 26 and and CC cord-005453-4057qib7 1188 27 -2 -2 CD cord-005453-4057qib7 1188 28 from from IN cord-005453-4057qib7 1188 29 an an DT cord-005453-4057qib7 1188 30 ' ' `` cord-005453-4057qib7 1188 31 inflammatory inflammatory JJ cord-005453-4057qib7 1188 32 ' ' '' cord-005453-4057qib7 1188 33 or or CC cord-005453-4057qib7 1188 34 ' ' `` cord-005453-4057qib7 1188 35 tumor tumor NN cord-005453-4057qib7 1188 36 - - HYPH cord-005453-4057qib7 1188 37 promoting promote VBG cord-005453-4057qib7 1188 38 ' ' '' cord-005453-4057qib7 1188 39 to to IN cord-005453-4057qib7 1188 40 an an DT cord-005453-4057qib7 1188 41 ' ' `` cord-005453-4057qib7 1188 42 antitumor'reactive antitumor'reactive NN cord-005453-4057qib7 1188 43 function function NN cord-005453-4057qib7 1188 44 . . . cord-005453-4057qib7 1189 1 This this DT cord-005453-4057qib7 1189 2 knowledge knowledge NN cord-005453-4057qib7 1189 3 can can MD cord-005453-4057qib7 1189 4 contribute contribute VB cord-005453-4057qib7 1189 5 to to TO cord-005453-4057qib7 1189 6 develop develop VB cord-005453-4057qib7 1189 7 immune immune NN cord-005453-4057qib7 1189 8 - - HYPH cord-005453-4057qib7 1189 9 modifying modify VBG cord-005453-4057qib7 1189 10 strategies strategy NNS cord-005453-4057qib7 1189 11 that that WDT cord-005453-4057qib7 1189 12 promote promote VBP cord-005453-4057qib7 1189 13 antileukemic antileukemic JJ cord-005453-4057qib7 1189 14 adaptive adaptive JJ cord-005453-4057qib7 1189 15 immune immune NN cord-005453-4057qib7 1189 16 - - HYPH cord-005453-4057qib7 1189 17 responses response NNS cord-005453-4057qib7 1189 18 . . . cord-005453-4057qib7 1190 1 Disclosure disclosure NN cord-005453-4057qib7 1190 2 : : : cord-005453-4057qib7 1190 3 Nothing nothing NN cord-005453-4057qib7 1190 4 to to TO cord-005453-4057qib7 1190 5 declare declare VB cord-005453-4057qib7 1190 6 Background background NN cord-005453-4057qib7 1190 7 : : : cord-005453-4057qib7 1190 8 Allogeneic allogeneic NN cord-005453-4057qib7 1190 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 1190 10 cell cell NN cord-005453-4057qib7 1190 11 transplantation transplantation NN cord-005453-4057qib7 1190 12 ( ( -LRB- cord-005453-4057qib7 1190 13 allo allo NN cord-005453-4057qib7 1190 14 - - HYPH cord-005453-4057qib7 1190 15 HCT HCT NNP cord-005453-4057qib7 1190 16 ) ) -RRB- cord-005453-4057qib7 1190 17 is be VBZ cord-005453-4057qib7 1190 18 a a DT cord-005453-4057qib7 1190 19 curative curative JJ cord-005453-4057qib7 1190 20 treatment treatment NN cord-005453-4057qib7 1190 21 option option NN cord-005453-4057qib7 1190 22 for for IN cord-005453-4057qib7 1190 23 patients patient NNS cord-005453-4057qib7 1190 24 suffering suffer VBG cord-005453-4057qib7 1190 25 from from IN cord-005453-4057qib7 1190 26 hematologic hematologic JJ cord-005453-4057qib7 1190 27 malignancies malignancy NNS cord-005453-4057qib7 1190 28 . . . cord-005453-4057qib7 1191 1 Infusion infusion NN cord-005453-4057qib7 1191 2 of of IN cord-005453-4057qib7 1191 3 donor donor NN cord-005453-4057qib7 1191 4 lymphocytes lymphocyte NNS cord-005453-4057qib7 1191 5 ( ( -LRB- cord-005453-4057qib7 1191 6 DLIs DLIs NNP cord-005453-4057qib7 1191 7 ) ) -RRB- cord-005453-4057qib7 1191 8 can can MD cord-005453-4057qib7 1191 9 induce induce VB cord-005453-4057qib7 1191 10 sustained sustained JJ cord-005453-4057qib7 1191 11 remission remission NN cord-005453-4057qib7 1191 12 in in IN cord-005453-4057qib7 1191 13 case case NN cord-005453-4057qib7 1191 14 of of IN cord-005453-4057qib7 1191 15 minimal minimal JJ cord-005453-4057qib7 1191 16 residual residual JJ cord-005453-4057qib7 1191 17 disease disease NN cord-005453-4057qib7 1191 18 or or CC cord-005453-4057qib7 1191 19 relapse relapse VB cord-005453-4057qib7 1191 20 through through IN cord-005453-4057qib7 1191 21 potent potent JJ cord-005453-4057qib7 1191 22 graftversus graftversus NN cord-005453-4057qib7 1191 23 - - HYPH cord-005453-4057qib7 1191 24 leukemia leukemia NN cord-005453-4057qib7 1191 25 ( ( -LRB- cord-005453-4057qib7 1191 26 GVL gvl NN cord-005453-4057qib7 1191 27 ) ) -RRB- cord-005453-4057qib7 1191 28 effects effect NNS cord-005453-4057qib7 1191 29 , , , cord-005453-4057qib7 1191 30 although although IN cord-005453-4057qib7 1191 31 graft graft NN cord-005453-4057qib7 1191 32 - - HYPH cord-005453-4057qib7 1191 33 versus versus IN cord-005453-4057qib7 1191 34 - - HYPH cord-005453-4057qib7 1191 35 host host NN cord-005453-4057qib7 1191 36 disease disease NN cord-005453-4057qib7 1191 37 ( ( -LRB- cord-005453-4057qib7 1191 38 GVHD GVHD NNP cord-005453-4057qib7 1191 39 ) ) -RRB- cord-005453-4057qib7 1191 40 represents represent VBZ cord-005453-4057qib7 1191 41 a a DT cord-005453-4057qib7 1191 42 common common JJ cord-005453-4057qib7 1191 43 dose dose NN cord-005453-4057qib7 1191 44 - - HYPH cord-005453-4057qib7 1191 45 limiting limit VBG cord-005453-4057qib7 1191 46 toxicity toxicity NN cord-005453-4057qib7 1191 47 . . . cord-005453-4057qib7 1192 1 As as IN cord-005453-4057qib7 1192 2 invariant invariant JJ cord-005453-4057qib7 1192 3 natural natural JJ cord-005453-4057qib7 1192 4 killer killer NN cord-005453-4057qib7 1192 5 T t NN cord-005453-4057qib7 1192 6 ( ( -LRB- cord-005453-4057qib7 1192 7 iNKT iNKT NNP cord-005453-4057qib7 1192 8 ) ) -RRB- cord-005453-4057qib7 1192 9 cells cell NNS cord-005453-4057qib7 1192 10 are be VBP cord-005453-4057qib7 1192 11 known know VBN cord-005453-4057qib7 1192 12 to to TO cord-005453-4057qib7 1192 13 prevent prevent VB cord-005453-4057qib7 1192 14 GVHD GVHD NNP cord-005453-4057qib7 1192 15 while while IN cord-005453-4057qib7 1192 16 promoting promote VBG cord-005453-4057qib7 1192 17 beneficial beneficial JJ cord-005453-4057qib7 1192 18 anti anti JJ cord-005453-4057qib7 1192 19 - - JJ cord-005453-4057qib7 1192 20 tumor tumor JJ cord-005453-4057qib7 1192 21 effects effect NNS cord-005453-4057qib7 1192 22 , , , cord-005453-4057qib7 1192 23 we -PRON- PRP cord-005453-4057qib7 1192 24 investigated investigate VBD cord-005453-4057qib7 1192 25 the the DT cord-005453-4057qib7 1192 26 role role NN cord-005453-4057qib7 1192 27 of of IN cord-005453-4057qib7 1192 28 iNKT inkt JJ cord-005453-4057qib7 1192 29 cells cell NNS cord-005453-4057qib7 1192 30 for for IN cord-005453-4057qib7 1192 31 successful successful JJ cord-005453-4057qib7 1192 32 DLIs dli NNS cord-005453-4057qib7 1192 33 . . . cord-005453-4057qib7 1193 1 Methods method NNS cord-005453-4057qib7 1193 2 : : : cord-005453-4057qib7 1194 1 We -PRON- PRP cord-005453-4057qib7 1194 2 analyzed analyze VBD cord-005453-4057qib7 1194 3 DLI DLI NNP cord-005453-4057qib7 1194 4 samples sample NNS cord-005453-4057qib7 1194 5 by by IN cord-005453-4057qib7 1194 6 flow flow NN cord-005453-4057qib7 1194 7 cytometry cytometry NN cord-005453-4057qib7 1194 8 . . . cord-005453-4057qib7 1195 1 iNKT inkt JJ cord-005453-4057qib7 1195 2 cells cell NNS cord-005453-4057qib7 1195 3 were be VBD cord-005453-4057qib7 1195 4 identified identify VBN cord-005453-4057qib7 1195 5 by by IN cord-005453-4057qib7 1195 6 staining stain VBG cord-005453-4057qib7 1195 7 with with IN cord-005453-4057qib7 1195 8 PBS57-loaded pbs57-loaded JJ cord-005453-4057qib7 1195 9 CD1d CD1d NNP cord-005453-4057qib7 1195 10 tetramers tetramer NNS cord-005453-4057qib7 1195 11 . . . cord-005453-4057qib7 1196 1 Culture culture NN cord-005453-4057qib7 1196 2 - - HYPH cord-005453-4057qib7 1196 3 expanded expand VBN cord-005453-4057qib7 1196 4 and and CC cord-005453-4057qib7 1196 5 purified purify VBN cord-005453-4057qib7 1196 6 DLI DLI NNP cord-005453-4057qib7 1196 7 - - HYPH cord-005453-4057qib7 1196 8 iNKTs iNKTs NNP cord-005453-4057qib7 1196 9 were be VBD cord-005453-4057qib7 1196 10 then then RB cord-005453-4057qib7 1196 11 tested test VBN cord-005453-4057qib7 1196 12 against against IN cord-005453-4057qib7 1196 13 tumor tumor NN cord-005453-4057qib7 1196 14 cell cell NN cord-005453-4057qib7 1196 15 lines line NNS cord-005453-4057qib7 1196 16 and and CC cord-005453-4057qib7 1196 17 primary primary JJ cord-005453-4057qib7 1196 18 leukemia leukemia NN cord-005453-4057qib7 1196 19 cells cell NNS cord-005453-4057qib7 1196 20 in in IN cord-005453-4057qib7 1196 21 an an DT cord-005453-4057qib7 1196 22 ex ex FW cord-005453-4057qib7 1196 23 vivo vivo NN cord-005453-4057qib7 1196 24 tumor tumor NN cord-005453-4057qib7 1196 25 control control NN cord-005453-4057qib7 1196 26 model model NN cord-005453-4057qib7 1196 27 . . . cord-005453-4057qib7 1197 1 Tumor tumor NN cord-005453-4057qib7 1197 2 cell cell NN cord-005453-4057qib7 1197 3 viability viability NN cord-005453-4057qib7 1197 4 after after IN cord-005453-4057qib7 1197 5 coincubation coincubation NN cord-005453-4057qib7 1197 6 with with IN cord-005453-4057qib7 1197 7 DLI DLI NNP cord-005453-4057qib7 1197 8 - - HYPH cord-005453-4057qib7 1197 9 iNKTs iNKTs NNP cord-005453-4057qib7 1197 10 was be VBD cord-005453-4057qib7 1197 11 measured measure VBN cord-005453-4057qib7 1197 12 by by IN cord-005453-4057qib7 1197 13 flow flow NN cord-005453-4057qib7 1197 14 cytometry cytometry NN cord-005453-4057qib7 1197 15 using use VBG cord-005453-4057qib7 1197 16 7-AAD 7-aad CD cord-005453-4057qib7 1197 17 . . . cord-005453-4057qib7 1198 1 Results result NNS cord-005453-4057qib7 1198 2 : : : cord-005453-4057qib7 1199 1 iNKT inkt JJ cord-005453-4057qib7 1199 2 cells cell NNS cord-005453-4057qib7 1199 3 represent represent VBP cord-005453-4057qib7 1199 4 0.05 0.05 CD cord-005453-4057qib7 1199 5 % % NN cord-005453-4057qib7 1199 6 ( ( -LRB- cord-005453-4057qib7 1199 7 range range NN cord-005453-4057qib7 1199 8 0.001 0.001 CD cord-005453-4057qib7 1199 9 - - HYPH cord-005453-4057qib7 1199 10 0.55 0.55 CD cord-005453-4057qib7 1199 11 % % NN cord-005453-4057qib7 1199 12 ) ) -RRB- cord-005453-4057qib7 1199 13 of of IN cord-005453-4057qib7 1199 14 donor donor NN cord-005453-4057qib7 1199 15 lymphocytes lymphocyte NNS cord-005453-4057qib7 1199 16 and and CC cord-005453-4057qib7 1199 17 can can MD cord-005453-4057qib7 1199 18 be be VB cord-005453-4057qib7 1199 19 expanded expand VBN cord-005453-4057qib7 1199 20 300fold 300fold NNP cord-005453-4057qib7 1199 21 following follow VBG cord-005453-4057qib7 1199 22 a a DT cord-005453-4057qib7 1199 23 two two CD cord-005453-4057qib7 1199 24 - - HYPH cord-005453-4057qib7 1199 25 week week NN cord-005453-4057qib7 1199 26 protocol protocol NN cord-005453-4057qib7 1199 27 with with IN cord-005453-4057qib7 1199 28 a a DT cord-005453-4057qib7 1199 29 preferential preferential JJ cord-005453-4057qib7 1199 30 expansion expansion NN cord-005453-4057qib7 1199 31 of of IN cord-005453-4057qib7 1199 32 CD4 CD4 NNP cord-005453-4057qib7 1199 33 + + CC cord-005453-4057qib7 1199 34 iNKT inkt JJ cord-005453-4057qib7 1199 35 cells cell NNS cord-005453-4057qib7 1199 36 . . . cord-005453-4057qib7 1200 1 Tumor tumor NN cord-005453-4057qib7 1200 2 cell cell NN cord-005453-4057qib7 1200 3 lines line NNS cord-005453-4057qib7 1200 4 such such JJ cord-005453-4057qib7 1200 5 as as IN cord-005453-4057qib7 1200 6 Jurkat Jurkat NNP cord-005453-4057qib7 1200 7 were be VBD cord-005453-4057qib7 1200 8 efficiently efficiently RB cord-005453-4057qib7 1200 9 lysed lyse VBN cord-005453-4057qib7 1200 10 after after IN cord-005453-4057qib7 1200 11 coincubation coincubation NN cord-005453-4057qib7 1200 12 with with IN cord-005453-4057qib7 1200 13 DLI DLI NNP cord-005453-4057qib7 1200 14 - - HYPH cord-005453-4057qib7 1200 15 iNKTs iNKTs NNPS cord-005453-4057qib7 1200 16 . . . cord-005453-4057qib7 1201 1 CD107a CD107a NNP cord-005453-4057qib7 1201 2 as as IN cord-005453-4057qib7 1201 3 a a DT cord-005453-4057qib7 1201 4 marker marker NN cord-005453-4057qib7 1201 5 of of IN cord-005453-4057qib7 1201 6 degranulation degranulation NN cord-005453-4057qib7 1201 7 was be VBD cord-005453-4057qib7 1201 8 significantly significantly RB cord-005453-4057qib7 1201 9 upregulated upregulate VBN cord-005453-4057qib7 1201 10 on on IN cord-005453-4057qib7 1201 11 DLI DLI NNP cord-005453-4057qib7 1201 12 - - HYPH cord-005453-4057qib7 1201 13 iNKTs iNKTs NNP cord-005453-4057qib7 1201 14 after after IN cord-005453-4057qib7 1201 15 stimulation stimulation NN cord-005453-4057qib7 1201 16 by by IN cord-005453-4057qib7 1201 17 Jurkat Jurkat NNP cord-005453-4057qib7 1201 18 . . . cord-005453-4057qib7 1202 1 In in IN cord-005453-4057qib7 1202 2 addition addition NN cord-005453-4057qib7 1202 3 , , , cord-005453-4057qib7 1202 4 increased increase VBN cord-005453-4057qib7 1202 5 concentrations concentration NNS cord-005453-4057qib7 1202 6 of of IN cord-005453-4057qib7 1202 7 TNFα TNFα NNS cord-005453-4057qib7 1202 8 , , , cord-005453-4057qib7 1202 9 IFN IFN NNP cord-005453-4057qib7 1202 10 - - HYPH cord-005453-4057qib7 1202 11 γ γ NNP cord-005453-4057qib7 1202 12 , , , cord-005453-4057qib7 1202 13 sFasL sFasL NNP cord-005453-4057qib7 1202 14 and and CC cord-005453-4057qib7 1202 15 Perforin Perforin NNP cord-005453-4057qib7 1202 16 were be VBD cord-005453-4057qib7 1202 17 measured measure VBN cord-005453-4057qib7 1202 18 after after IN cord-005453-4057qib7 1202 19 coincubation coincubation NN cord-005453-4057qib7 1202 20 of of IN cord-005453-4057qib7 1202 21 DLI DLI NNP cord-005453-4057qib7 1202 22 - - HYPH cord-005453-4057qib7 1202 23 iNKTs iNKTs NNP cord-005453-4057qib7 1202 24 with with IN cord-005453-4057qib7 1202 25 Jurkat Jurkat NNP cord-005453-4057qib7 1202 26 . . . cord-005453-4057qib7 1203 1 We -PRON- PRP cord-005453-4057qib7 1203 2 observed observe VBD cord-005453-4057qib7 1203 3 that that DT cord-005453-4057qib7 1203 4 tumor tumor NN cord-005453-4057qib7 1203 5 cell cell NN cord-005453-4057qib7 1203 6 lysis lysis NN cord-005453-4057qib7 1203 7 correlated correlate VBN cord-005453-4057qib7 1203 8 with with IN cord-005453-4057qib7 1203 9 the the DT cord-005453-4057qib7 1203 10 expression expression NN cord-005453-4057qib7 1203 11 of of IN cord-005453-4057qib7 1203 12 the the DT cord-005453-4057qib7 1203 13 MHC MHC NNP cord-005453-4057qib7 1203 14 - - HYPH cord-005453-4057qib7 1203 15 I I NNP cord-005453-4057qib7 1203 16 - - HYPH cord-005453-4057qib7 1203 17 like like JJ cord-005453-4057qib7 1203 18 molecule molecule NN cord-005453-4057qib7 1203 19 CD1d CD1d NNP cord-005453-4057qib7 1203 20 . . . cord-005453-4057qib7 1204 1 Consequently consequently RB cord-005453-4057qib7 1204 2 , , , cord-005453-4057qib7 1204 3 adding add VBG cord-005453-4057qib7 1204 4 a a DT cord-005453-4057qib7 1204 5 CD1d CD1d NNP cord-005453-4057qib7 1204 6 antibody antibody NN cord-005453-4057qib7 1204 7 to to IN cord-005453-4057qib7 1204 8 the the DT cord-005453-4057qib7 1204 9 coculture coculture NN cord-005453-4057qib7 1204 10 abrogated abrogate VBD cord-005453-4057qib7 1204 11 the the DT cord-005453-4057qib7 1204 12 DLI DLI NNP cord-005453-4057qib7 1204 13 - - HYPH cord-005453-4057qib7 1204 14 iNKTmediated inktmediate VBN cord-005453-4057qib7 1204 15 kill kill NN cord-005453-4057qib7 1204 16 of of IN cord-005453-4057qib7 1204 17 tumor tumor NN cord-005453-4057qib7 1204 18 cells cell NNS cord-005453-4057qib7 1204 19 . . . cord-005453-4057qib7 1205 1 DLI DLI NNP cord-005453-4057qib7 1205 2 - - HYPH cord-005453-4057qib7 1205 3 iNKTs iNKTs NNP cord-005453-4057qib7 1205 4 also also RB cord-005453-4057qib7 1205 5 efficiently efficiently RB cord-005453-4057qib7 1205 6 lysed lyse VBN cord-005453-4057qib7 1205 7 primary primary JJ cord-005453-4057qib7 1205 8 leukemia leukemia NN cord-005453-4057qib7 1205 9 cells cell NNS cord-005453-4057qib7 1205 10 such such JJ cord-005453-4057qib7 1205 11 as as IN cord-005453-4057qib7 1205 12 AML AML NNP cord-005453-4057qib7 1205 13 blasts blast NNS cord-005453-4057qib7 1205 14 : : : cord-005453-4057qib7 1205 15 expression expression NN cord-005453-4057qib7 1205 16 of of IN cord-005453-4057qib7 1205 17 CD1d CD1d NNP cord-005453-4057qib7 1205 18 on on IN cord-005453-4057qib7 1205 19 these these DT cord-005453-4057qib7 1205 20 AML AML NNP cord-005453-4057qib7 1205 21 blasts blast NNS cord-005453-4057qib7 1205 22 significantly significantly RB cord-005453-4057qib7 1205 23 correlated correlate VBD cord-005453-4057qib7 1205 24 with with IN cord-005453-4057qib7 1205 25 DLI DLI NNP cord-005453-4057qib7 1205 26 - - HYPH cord-005453-4057qib7 1205 27 iNKT inkt JJ cord-005453-4057qib7 1205 28 - - HYPH cord-005453-4057qib7 1205 29 mediated mediate VBN cord-005453-4057qib7 1205 30 tumor tumor NN cord-005453-4057qib7 1205 31 cell cell NN cord-005453-4057qib7 1205 32 lysis lysis NN cord-005453-4057qib7 1205 33 ( ( -LRB- cord-005453-4057qib7 1205 34 r r NN cord-005453-4057qib7 1205 35 2 2 CD cord-005453-4057qib7 1205 36 = = SYM cord-005453-4057qib7 1205 37 0.7 0.7 CD cord-005453-4057qib7 1205 38 , , , cord-005453-4057qib7 1205 39 p=0.03 p=0.03 NNP cord-005453-4057qib7 1205 40 ) ) -RRB- cord-005453-4057qib7 1205 41 . . . cord-005453-4057qib7 1206 1 Conclusions conclusion NNS cord-005453-4057qib7 1206 2 : : : cord-005453-4057qib7 1207 1 Ex Ex NNP cord-005453-4057qib7 1207 2 vivo vivo NN cord-005453-4057qib7 1207 3 expansion expansion NN cord-005453-4057qib7 1207 4 of of IN cord-005453-4057qib7 1207 5 DLI DLI NNP cord-005453-4057qib7 1207 6 - - HYPH cord-005453-4057qib7 1207 7 iNKTs iNKTs NNPS cord-005453-4057qib7 1207 8 and and CC cord-005453-4057qib7 1207 9 subsequent subsequent JJ cord-005453-4057qib7 1207 10 DLI DLI NNP cord-005453-4057qib7 1207 11 enrichment enrichment NN cord-005453-4057qib7 1207 12 is be VBZ cord-005453-4057qib7 1207 13 an an DT cord-005453-4057qib7 1207 14 immunotherapeutic immunotherapeutic JJ cord-005453-4057qib7 1207 15 approach approach NN cord-005453-4057qib7 1207 16 that that WDT cord-005453-4057qib7 1207 17 could could MD cord-005453-4057qib7 1207 18 improve improve VB cord-005453-4057qib7 1207 19 leukemia leukemia NN cord-005453-4057qib7 1207 20 control control NN cord-005453-4057qib7 1207 21 and and CC cord-005453-4057qib7 1207 22 thus thus RB cord-005453-4057qib7 1207 23 , , , cord-005453-4057qib7 1207 24 prevent prevent VB cord-005453-4057qib7 1207 25 relapse relapse NN cord-005453-4057qib7 1207 26 after after IN cord-005453-4057qib7 1207 27 allo allo NN cord-005453-4057qib7 1207 28 - - HYPH cord-005453-4057qib7 1207 29 HCT hct NN cord-005453-4057qib7 1207 30 without without IN cord-005453-4057qib7 1207 31 exacerbating exacerbate VBG cord-005453-4057qib7 1207 32 GVHD GVHD NNP cord-005453-4057qib7 1207 33 . . . cord-005453-4057qib7 1208 1 Disclosure disclosure NN cord-005453-4057qib7 1208 2 : : : cord-005453-4057qib7 1208 3 Nothing nothing NN cord-005453-4057qib7 1208 4 to to TO cord-005453-4057qib7 1208 5 declare declare VB cord-005453-4057qib7 1208 6 . . . cord-005453-4057qib7 1209 1 Generation generation NN cord-005453-4057qib7 1209 2 of of IN cord-005453-4057qib7 1209 3 antigen antigen NN cord-005453-4057qib7 1209 4 - - HYPH cord-005453-4057qib7 1209 5 specific specific JJ cord-005453-4057qib7 1209 6 cytotoxic cytotoxic JJ cord-005453-4057qib7 1209 7 T t NN cord-005453-4057qib7 1209 8 lymphocytes lymphocyte NNS cord-005453-4057qib7 1209 9 targeting target VBG cord-005453-4057qib7 1209 10 WT1 wt1 RB cord-005453-4057qib7 1209 11 using use VBG cord-005453-4057qib7 1209 12 activated activate VBN cord-005453-4057qib7 1209 13 B b NN cord-005453-4057qib7 1209 14 cells cell NNS cord-005453-4057qib7 1209 15 Sun Sun NNP cord-005453-4057qib7 1209 16 Ok Ok NNP cord-005453-4057qib7 1209 17 Yun Yun NNP cord-005453-4057qib7 1209 18 1 1 CD cord-005453-4057qib7 1209 19 , , , cord-005453-4057qib7 1209 20 Kyung Kyung NNP cord-005453-4057qib7 1209 21 Won Won NNP cord-005453-4057qib7 1209 22 Baek Baek NNP cord-005453-4057qib7 1209 23 1 1 CD cord-005453-4057qib7 1209 24 , , , cord-005453-4057qib7 1210 1 Hee hee UH cord-005453-4057qib7 1210 2 Young Young NNP cord-005453-4057qib7 1210 3 Shin Shin NNP cord-005453-4057qib7 1210 4 1 1 CD cord-005453-4057qib7 1210 5 , , , cord-005453-4057qib7 1210 6 Hyoung Hyoung NNP cord-005453-4057qib7 1210 7 Jin Jin NNP cord-005453-4057qib7 1210 8 Kang Kang NNP cord-005453-4057qib7 1210 9 1 1 CD cord-005453-4057qib7 1210 10 1 1 CD cord-005453-4057qib7 1210 11 Seoul Seoul NNP cord-005453-4057qib7 1210 12 National National NNP cord-005453-4057qib7 1210 13 University University NNP cord-005453-4057qib7 1210 14 , , , cord-005453-4057qib7 1210 15 Seoul Seoul NNP cord-005453-4057qib7 1210 16 , , , cord-005453-4057qib7 1210 17 Korea Korea NNP cord-005453-4057qib7 1210 18 , , , cord-005453-4057qib7 1210 19 Republic Republic NNP cord-005453-4057qib7 1210 20 of of IN cord-005453-4057qib7 1210 21 Background Background NNP cord-005453-4057qib7 1210 22 : : : cord-005453-4057qib7 1211 1 The the DT cord-005453-4057qib7 1211 2 Wilms Wilms NNP cord-005453-4057qib7 1211 3 tumor tumor NN cord-005453-4057qib7 1211 4 antigen antigen NN cord-005453-4057qib7 1211 5 1 1 CD cord-005453-4057qib7 1212 1 ( ( -LRB- cord-005453-4057qib7 1212 2 WT1 wt1 NN cord-005453-4057qib7 1212 3 ) ) -RRB- cord-005453-4057qib7 1212 4 is be VBZ cord-005453-4057qib7 1212 5 highly highly RB cord-005453-4057qib7 1212 6 expressed express VBN cord-005453-4057qib7 1212 7 in in IN cord-005453-4057qib7 1212 8 many many JJ cord-005453-4057qib7 1212 9 malignancies malignancy NNS cord-005453-4057qib7 1212 10 including include VBG cord-005453-4057qib7 1212 11 leukemia leukemia NN cord-005453-4057qib7 1212 12 and and CC cord-005453-4057qib7 1212 13 targeting target VBG cord-005453-4057qib7 1212 14 WT1 wt1 RB cord-005453-4057qib7 1212 15 as as IN cord-005453-4057qib7 1212 16 a a DT cord-005453-4057qib7 1212 17 Tumor tumor NN cord-005453-4057qib7 1212 18 Associated Associated NNP cord-005453-4057qib7 1212 19 Antigen Antigen NNP cord-005453-4057qib7 1212 20 ( ( -LRB- cord-005453-4057qib7 1212 21 TAA TAA NNP cord-005453-4057qib7 1212 22 ) ) -RRB- cord-005453-4057qib7 1212 23 in in IN cord-005453-4057qib7 1212 24 cancer cancer NN cord-005453-4057qib7 1212 25 immunotherapy immunotherapy NN cord-005453-4057qib7 1212 26 is be VBZ cord-005453-4057qib7 1212 27 attractive attractive JJ cord-005453-4057qib7 1212 28 . . . cord-005453-4057qib7 1213 1 In in IN cord-005453-4057qib7 1213 2 this this DT cord-005453-4057qib7 1213 3 study study NN cord-005453-4057qib7 1213 4 , , , cord-005453-4057qib7 1213 5 we -PRON- PRP cord-005453-4057qib7 1213 6 generated generate VBD cord-005453-4057qib7 1213 7 WT1-specific wt1-specific JJ cord-005453-4057qib7 1213 8 cytotoxic cytotoxic JJ cord-005453-4057qib7 1213 9 T t NN cord-005453-4057qib7 1213 10 lymphocytes lymphocyte NNS cord-005453-4057qib7 1213 11 to to TO cord-005453-4057qib7 1213 12 confirm confirm VB cord-005453-4057qib7 1213 13 if if IN cord-005453-4057qib7 1213 14 activated activate VBN cord-005453-4057qib7 1213 15 B b NN cord-005453-4057qib7 1213 16 cells cell NNS cord-005453-4057qib7 1213 17 can can MD cord-005453-4057qib7 1213 18 act act VB cord-005453-4057qib7 1213 19 as as IN cord-005453-4057qib7 1213 20 a a DT cord-005453-4057qib7 1213 21 cancer cancer NN cord-005453-4057qib7 1213 22 antigen antigen NN cord-005453-4057qib7 1213 23 presenting present VBG cord-005453-4057qib7 1213 24 cell cell NN cord-005453-4057qib7 1213 25 and and CC cord-005453-4057qib7 1213 26 induce induce VB cord-005453-4057qib7 1213 27 CTLs ctl NNS cord-005453-4057qib7 1213 28 . . . cord-005453-4057qib7 1214 1 Methods method NNS cord-005453-4057qib7 1214 2 : : : cord-005453-4057qib7 1214 3 For for IN cord-005453-4057qib7 1214 4 the the DT cord-005453-4057qib7 1214 5 induction induction NN cord-005453-4057qib7 1214 6 of of IN cord-005453-4057qib7 1214 7 CTLs ctl NNS cord-005453-4057qib7 1214 8 against against IN cord-005453-4057qib7 1214 9 WT1 WT1 NNP cord-005453-4057qib7 1214 10 , , , cord-005453-4057qib7 1214 11 activated activate VBN cord-005453-4057qib7 1214 12 B b NN cord-005453-4057qib7 1214 13 cells cell NNS cord-005453-4057qib7 1214 14 were be VBD cord-005453-4057qib7 1214 15 used use VBN cord-005453-4057qib7 1214 16 as as IN cord-005453-4057qib7 1214 17 an an DT cord-005453-4057qib7 1214 18 antigen antigen NN cord-005453-4057qib7 1214 19 presenting present VBG cord-005453-4057qib7 1214 20 cells cell NNS cord-005453-4057qib7 1214 21 . . . cord-005453-4057qib7 1215 1 B b NN cord-005453-4057qib7 1215 2 cells cell NNS cord-005453-4057qib7 1215 3 were be VBD cord-005453-4057qib7 1215 4 isolated isolate VBN cord-005453-4057qib7 1215 5 from from IN cord-005453-4057qib7 1215 6 PBMCs pbmc NNS cord-005453-4057qib7 1215 7 of of IN cord-005453-4057qib7 1215 8 normal normal JJ cord-005453-4057qib7 1215 9 healthy healthy JJ cord-005453-4057qib7 1215 10 donors donor NNS cord-005453-4057qib7 1215 11 and and CC cord-005453-4057qib7 1215 12 activated activate VBN cord-005453-4057qib7 1215 13 with with IN cord-005453-4057qib7 1215 14 α α NN cord-005453-4057qib7 1215 15 - - HYPH cord-005453-4057qib7 1215 16 galactosylceramide galactosylceramide NN cord-005453-4057qib7 1215 17 ( ( -LRB- cord-005453-4057qib7 1215 18 α α NN cord-005453-4057qib7 1215 19 - - HYPH cord-005453-4057qib7 1215 20 GalCer galcer NN cord-005453-4057qib7 1215 21 ) ) -RRB- cord-005453-4057qib7 1215 22 and and CC cord-005453-4057qib7 1215 23 nucleofected nucleofecte VBD cord-005453-4057qib7 1215 24 with with IN cord-005453-4057qib7 1215 25 WT1-coding wt1-code VBG cord-005453-4057qib7 1215 26 plasmid plasmid NN cord-005453-4057qib7 1215 27 DNA dna NN cord-005453-4057qib7 1215 28 . . . cord-005453-4057qib7 1216 1 Activated activate VBN cord-005453-4057qib7 1216 2 B B NNP cord-005453-4057qib7 1216 3 cells cell NNS cord-005453-4057qib7 1216 4 were be VBD cord-005453-4057qib7 1216 5 the the DT cord-005453-4057qib7 1216 6 cultured cultured JJ cord-005453-4057qib7 1216 7 with with IN cord-005453-4057qib7 1216 8 PBMCs pbmc NNS cord-005453-4057qib7 1216 9 for for IN cord-005453-4057qib7 1216 10 17days 17days CD cord-005453-4057qib7 1216 11 in in IN cord-005453-4057qib7 1216 12 vitro vitro FW cord-005453-4057qib7 1216 13 and and CC cord-005453-4057qib7 1216 14 harvested harvest VBN cord-005453-4057qib7 1216 15 for for IN cord-005453-4057qib7 1216 16 assay assay NN cord-005453-4057qib7 1216 17 . . . cord-005453-4057qib7 1217 1 Results result NNS cord-005453-4057qib7 1217 2 : : : cord-005453-4057qib7 1218 1 Cells cell NNS cord-005453-4057qib7 1218 2 expanded expand VBD cord-005453-4057qib7 1218 3 about about IN cord-005453-4057qib7 1218 4 3 3 CD cord-005453-4057qib7 1218 5 times time NNS cord-005453-4057qib7 1218 6 after after IN cord-005453-4057qib7 1218 7 17 17 CD cord-005453-4057qib7 1218 8 days day NNS cord-005453-4057qib7 1218 9 of of IN cord-005453-4057qib7 1218 10 culture culture NN cord-005453-4057qib7 1218 11 . . . cord-005453-4057qib7 1219 1 We -PRON- PRP cord-005453-4057qib7 1219 2 examined examine VBD cord-005453-4057qib7 1219 3 characteristic characteristic NN cord-005453-4057qib7 1219 4 of of IN cord-005453-4057qib7 1219 5 WT1-specific wt1-specific JJ cord-005453-4057qib7 1219 6 CTLs ctl NNS cord-005453-4057qib7 1219 7 by by IN cord-005453-4057qib7 1219 8 their -PRON- PRP$ cord-005453-4057qib7 1219 9 surface surface NN cord-005453-4057qib7 1219 10 markers marker NNS cord-005453-4057qib7 1219 11 . . . cord-005453-4057qib7 1220 1 WT1-specific WT1-specific NNP cord-005453-4057qib7 1220 2 CTLs CTLs NNP cord-005453-4057qib7 1220 3 had have VBD cord-005453-4057qib7 1220 4 more more JJR cord-005453-4057qib7 1220 5 than than IN cord-005453-4057qib7 1220 6 90 90 CD cord-005453-4057qib7 1220 7 % % NN cord-005453-4057qib7 1220 8 CD3 cd3 NN cord-005453-4057qib7 1220 9 + + CC cord-005453-4057qib7 1220 10 marker marker NN cord-005453-4057qib7 1220 11 , , , cord-005453-4057qib7 1220 12 and and CC cord-005453-4057qib7 1220 13 ratio ratio NN cord-005453-4057qib7 1220 14 of of IN cord-005453-4057qib7 1220 15 CD8 CD8 NNP cord-005453-4057qib7 1220 16 to to IN cord-005453-4057qib7 1220 17 CD4 CD4 NNP cord-005453-4057qib7 1220 18 was be VBD cord-005453-4057qib7 1220 19 1.7 1.7 CD cord-005453-4057qib7 1220 20 - - SYM cord-005453-4057qib7 1220 21 5.8 5.8 CD cord-005453-4057qib7 1220 22 . . . cord-005453-4057qib7 1221 1 We -PRON- PRP cord-005453-4057qib7 1221 2 also also RB cord-005453-4057qib7 1221 3 examined examine VBD cord-005453-4057qib7 1221 4 NKT NKT NNP cord-005453-4057qib7 1221 5 cell cell NN cord-005453-4057qib7 1221 6 markers marker NNS cord-005453-4057qib7 1221 7 to to TO cord-005453-4057qib7 1221 8 see see VB cord-005453-4057qib7 1221 9 if if IN cord-005453-4057qib7 1221 10 NKT NKT NNP cord-005453-4057qib7 1221 11 cells cell NNS cord-005453-4057qib7 1221 12 were be VBD cord-005453-4057qib7 1221 13 activated activate VBN cord-005453-4057qib7 1221 14 by by IN cord-005453-4057qib7 1221 15 IL-15 IL-15 NNP cord-005453-4057qib7 1221 16 , , , cord-005453-4057qib7 1221 17 a a DT cord-005453-4057qib7 1221 18 cytokine cytokine NN cord-005453-4057qib7 1221 19 used use VBN cord-005453-4057qib7 1221 20 in in IN cord-005453-4057qib7 1221 21 the the DT cord-005453-4057qib7 1221 22 induction induction NN cord-005453-4057qib7 1221 23 of of IN cord-005453-4057qib7 1221 24 CTLs CTLs NNP cord-005453-4057qib7 1221 25 , , , cord-005453-4057qib7 1221 26 and and CC cord-005453-4057qib7 1221 27 the the DT cord-005453-4057qib7 1221 28 portion portion NN cord-005453-4057qib7 1221 29 of of IN cord-005453-4057qib7 1221 30 NKT NKT NNP cord-005453-4057qib7 1221 31 cells cell NNS cord-005453-4057qib7 1221 32 was be VBD cord-005453-4057qib7 1221 33 about about RB cord-005453-4057qib7 1221 34 2 2 CD cord-005453-4057qib7 1221 35 % % NN cord-005453-4057qib7 1221 36 . . . cord-005453-4057qib7 1222 1 The the DT cord-005453-4057qib7 1222 2 CTLs ctl NNS cord-005453-4057qib7 1222 3 showed show VBD cord-005453-4057qib7 1222 4 a a DT cord-005453-4057qib7 1222 5 decrease decrease NN cord-005453-4057qib7 1222 6 in in IN cord-005453-4057qib7 1222 7 naïve naïve JJ cord-005453-4057qib7 1222 8 cell cell NN cord-005453-4057qib7 1222 9 ( ( -LRB- cord-005453-4057qib7 1222 10 CD62L+CD45RA CD62L+CD45RA NNP cord-005453-4057qib7 1222 11 + + SYM cord-005453-4057qib7 1222 12 ) ) -RRB- cord-005453-4057qib7 1222 13 and and CC cord-005453-4057qib7 1222 14 an an DT cord-005453-4057qib7 1222 15 increase increase NN cord-005453-4057qib7 1222 16 in in IN cord-005453-4057qib7 1222 17 effector effector NN cord-005453-4057qib7 1222 18 memory memory NN cord-005453-4057qib7 1222 19 ( ( -LRB- cord-005453-4057qib7 1222 20 CD62L+CD45RA- CD62L+CD45RA- NNP cord-005453-4057qib7 1222 21 ) ) -RRB- cord-005453-4057qib7 1222 22 and and CC cord-005453-4057qib7 1222 23 central central JJ cord-005453-4057qib7 1222 24 memory memory NN cord-005453-4057qib7 1222 25 ( ( -LRB- cord-005453-4057qib7 1222 26 CD62L cd62l NN cord-005453-4057qib7 1222 27 - - HYPH cord-005453-4057qib7 1222 28 CD45RA- CD45RA- NNP cord-005453-4057qib7 1222 29 ) ) -RRB- cord-005453-4057qib7 1222 30 compared compare VBN cord-005453-4057qib7 1222 31 with with IN cord-005453-4057qib7 1222 32 non non JJ cord-005453-4057qib7 1222 33 - - JJ cord-005453-4057qib7 1222 34 stimulated stimulated JJ cord-005453-4057qib7 1222 35 PBMCs pbmc NNS cord-005453-4057qib7 1222 36 . . . cord-005453-4057qib7 1223 1 Subsequently subsequently RB cord-005453-4057qib7 1223 2 , , , cord-005453-4057qib7 1223 3 the the DT cord-005453-4057qib7 1223 4 IFN IFN NNP cord-005453-4057qib7 1223 5 - - HYPH cord-005453-4057qib7 1223 6 γ γ NN cord-005453-4057qib7 1223 7 ELISPOT ELISPOT NNP cord-005453-4057qib7 1223 8 ( ( -LRB- cord-005453-4057qib7 1223 9 Enzyme enzyme NN cord-005453-4057qib7 1223 10 - - HYPH cord-005453-4057qib7 1223 11 linked link VBN cord-005453-4057qib7 1223 12 immunospot immunospot NN cord-005453-4057qib7 1223 13 ) ) -RRB- cord-005453-4057qib7 1223 14 assay assay NN cord-005453-4057qib7 1223 15 was be VBD cord-005453-4057qib7 1223 16 performed perform VBN cord-005453-4057qib7 1223 17 to to TO cord-005453-4057qib7 1223 18 confirm confirm VB cord-005453-4057qib7 1223 19 the the DT cord-005453-4057qib7 1223 20 response response NN cord-005453-4057qib7 1223 21 of of IN cord-005453-4057qib7 1223 22 the the DT cord-005453-4057qib7 1223 23 induced induce VBN cord-005453-4057qib7 1223 24 WT1-specific wt1-specific CD cord-005453-4057qib7 1223 25 CTLs ctl NNS cord-005453-4057qib7 1223 26 to to IN cord-005453-4057qib7 1223 27 the the DT cord-005453-4057qib7 1223 28 WT1 WT1 NNP cord-005453-4057qib7 1223 29 antigen antigen NN cord-005453-4057qib7 1223 30 . . . cord-005453-4057qib7 1224 1 When when WRB cord-005453-4057qib7 1224 2 WT1-specific wt1-specific JJ cord-005453-4057qib7 1224 3 CTLs CTLs NNP cord-005453-4057qib7 1224 4 encounters encounter VBZ cord-005453-4057qib7 1224 5 a a DT cord-005453-4057qib7 1224 6 target target NN cord-005453-4057qib7 1224 7 that that WDT cord-005453-4057qib7 1224 8 does do VBZ cord-005453-4057qib7 1224 9 not not RB cord-005453-4057qib7 1224 10 have have VB cord-005453-4057qib7 1224 11 a a DT cord-005453-4057qib7 1224 12 WT1 WT1 NNP cord-005453-4057qib7 1224 13 antigen antigen NN cord-005453-4057qib7 1224 14 , , , cord-005453-4057qib7 1224 15 it -PRON- PRP cord-005453-4057qib7 1224 16 did do VBD cord-005453-4057qib7 1224 17 not not RB cord-005453-4057qib7 1224 18 produce produce VB cord-005453-4057qib7 1224 19 IFN IFN NNP cord-005453-4057qib7 1224 20 - - HYPH cord-005453-4057qib7 1224 21 γ γ NNP cord-005453-4057qib7 1224 22 , , , cord-005453-4057qib7 1224 23 but but CC cord-005453-4057qib7 1224 24 when when WRB cord-005453-4057qib7 1224 25 it -PRON- PRP cord-005453-4057qib7 1224 26 encounters encounter VBZ cord-005453-4057qib7 1224 27 a a DT cord-005453-4057qib7 1224 28 target target NN cord-005453-4057qib7 1224 29 cells cell NNS cord-005453-4057qib7 1224 30 loaded load VBN cord-005453-4057qib7 1224 31 WT1 WT1 NNP cord-005453-4057qib7 1224 32 antigen antigen NN cord-005453-4057qib7 1224 33 , , , cord-005453-4057qib7 1224 34 it -PRON- PRP cord-005453-4057qib7 1224 35 responded respond VBD cord-005453-4057qib7 1224 36 to to TO cord-005453-4057qib7 1224 37 secrete secrete VB cord-005453-4057qib7 1224 38 IFN IFN NNP cord-005453-4057qib7 1224 39 - - HYPH cord-005453-4057qib7 1224 40 γ γ NNP cord-005453-4057qib7 1224 41 . . . cord-005453-4057qib7 1225 1 Killing kill VBG cord-005453-4057qib7 1225 2 assays assay NNS cord-005453-4057qib7 1225 3 were be VBD cord-005453-4057qib7 1225 4 also also RB cord-005453-4057qib7 1225 5 performed perform VBN cord-005453-4057qib7 1225 6 to to TO cord-005453-4057qib7 1225 7 determine determine VB cord-005453-4057qib7 1225 8 the the DT cord-005453-4057qib7 1225 9 immunogenicity immunogenicity NN cord-005453-4057qib7 1225 10 of of IN cord-005453-4057qib7 1225 11 induced induce VBN cord-005453-4057qib7 1225 12 CTLs CTLs NNP cord-005453-4057qib7 1225 13 . . . cord-005453-4057qib7 1226 1 The the DT cord-005453-4057qib7 1226 2 induced induce VBN cord-005453-4057qib7 1226 3 WT1 WT1 NNP cord-005453-4057qib7 1226 4 CTLs CTLs NNP cord-005453-4057qib7 1226 5 was be VBD cord-005453-4057qib7 1226 6 found find VBN cord-005453-4057qib7 1226 7 to to TO cord-005453-4057qib7 1226 8 be be VB cord-005453-4057qib7 1226 9 killing kill VBG cord-005453-4057qib7 1226 10 more more JJR cord-005453-4057qib7 1226 11 than than IN cord-005453-4057qib7 1226 12 90 90 CD cord-005453-4057qib7 1226 13 % % NN cord-005453-4057qib7 1226 14 when when WRB cord-005453-4057qib7 1226 15 the the DT cord-005453-4057qib7 1226 16 E e NN cord-005453-4057qib7 1226 17 : : : cord-005453-4057qib7 1226 18 T t NN cord-005453-4057qib7 1226 19 ratio ratio NN cord-005453-4057qib7 1226 20 was be VBD cord-005453-4057qib7 1226 21 10:1 10:1 CD cord-005453-4057qib7 1226 22 when when WRB cord-005453-4057qib7 1226 23 the the DT cord-005453-4057qib7 1226 24 autologous autologous JJ cord-005453-4057qib7 1226 25 PBMC PBMC NNP cord-005453-4057qib7 1226 26 met meet VBD cord-005453-4057qib7 1226 27 the the DT cord-005453-4057qib7 1226 28 target target NN cord-005453-4057qib7 1226 29 with with IN cord-005453-4057qib7 1226 30 WT1 wt1 JJ cord-005453-4057qib7 1226 31 pepmix pepmix NNS cord-005453-4057qib7 1226 32 . . . cord-005453-4057qib7 1227 1 In in IN cord-005453-4057qib7 1227 2 addition addition NN cord-005453-4057qib7 1227 3 , , , cord-005453-4057qib7 1227 4 we -PRON- PRP cord-005453-4057qib7 1227 5 found find VBD cord-005453-4057qib7 1227 6 that that IN cord-005453-4057qib7 1227 7 WT1 WT1 NNP cord-005453-4057qib7 1227 8 CTLs CTLs NNP cord-005453-4057qib7 1227 9 has have VBZ cord-005453-4057qib7 1227 10 killing kill VBG cord-005453-4057qib7 1227 11 activity activity NN cord-005453-4057qib7 1227 12 when when WRB cord-005453-4057qib7 1227 13 it -PRON- PRP cord-005453-4057qib7 1227 14 encounters encounter VBZ cord-005453-4057qib7 1227 15 leukemia leukemia NN cord-005453-4057qib7 1227 16 cell cell NN cord-005453-4057qib7 1227 17 lines line NNS cord-005453-4057qib7 1227 18 that that WDT cord-005453-4057qib7 1227 19 express express VBP cord-005453-4057qib7 1227 20 WT1 WT1 NNP cord-005453-4057qib7 1227 21 and and CC cord-005453-4057qib7 1227 22 matched match VBD cord-005453-4057qib7 1227 23 HLA HLA NNP cord-005453-4057qib7 1227 24 - - HYPH cord-005453-4057qib7 1227 25 A*0201 A*0201 NNP cord-005453-4057qib7 1227 26 . . . cord-005453-4057qib7 1228 1 Conclusions conclusion NNS cord-005453-4057qib7 1228 2 : : : cord-005453-4057qib7 1229 1 In in IN cord-005453-4057qib7 1229 2 this this DT cord-005453-4057qib7 1229 3 study study NN cord-005453-4057qib7 1229 4 , , , cord-005453-4057qib7 1229 5 we -PRON- PRP cord-005453-4057qib7 1229 6 can can MD cord-005453-4057qib7 1229 7 induce induce VB cord-005453-4057qib7 1229 8 antigenspecific antigenspecific NNP cord-005453-4057qib7 1229 9 CTLs ctl NNS cord-005453-4057qib7 1229 10 that that WDT cord-005453-4057qib7 1229 11 specifically specifically RB cord-005453-4057qib7 1229 12 react react VBP cord-005453-4057qib7 1229 13 to to IN cord-005453-4057qib7 1229 14 WT1 wt1 NN cord-005453-4057qib7 1229 15 using use VBG cord-005453-4057qib7 1229 16 activated activate VBN cord-005453-4057qib7 1229 17 B B NNP cord-005453-4057qib7 1229 18 cells cell NNS cord-005453-4057qib7 1229 19 as as IN cord-005453-4057qib7 1229 20 antigen antigen NN cord-005453-4057qib7 1229 21 - - HYPH cord-005453-4057qib7 1229 22 presenting present VBG cord-005453-4057qib7 1229 23 cells cell NNS cord-005453-4057qib7 1229 24 . . . cord-005453-4057qib7 1230 1 These these DT cord-005453-4057qib7 1230 2 observations observation NNS cord-005453-4057qib7 1230 3 confirmed confirm VBD cord-005453-4057qib7 1230 4 that that IN cord-005453-4057qib7 1230 5 B b NN cord-005453-4057qib7 1230 6 cells cell NNS cord-005453-4057qib7 1230 7 activated activate VBN cord-005453-4057qib7 1230 8 by by IN cord-005453-4057qib7 1230 9 α α NN cord-005453-4057qib7 1230 10 - - : cord-005453-4057qib7 1230 11 GalCer GalCer NNP cord-005453-4057qib7 1230 12 can can MD cord-005453-4057qib7 1230 13 act act VB cord-005453-4057qib7 1230 14 as as IN cord-005453-4057qib7 1230 15 a a DT cord-005453-4057qib7 1230 16 TAA TAA NNP cord-005453-4057qib7 1230 17 presenting present VBG cord-005453-4057qib7 1230 18 cell cell NN cord-005453-4057qib7 1230 19 to to TO cord-005453-4057qib7 1230 20 induce induce VB cord-005453-4057qib7 1230 21 TAA TAA NNP cord-005453-4057qib7 1230 22 specific specific JJ cord-005453-4057qib7 1230 23 CTLs ctl NNS cord-005453-4057qib7 1230 24 as as IN cord-005453-4057qib7 1230 25 viral viral JJ cord-005453-4057qib7 1230 26 antigen antigen NN cord-005453-4057qib7 1230 27 , , , cord-005453-4057qib7 1230 28 such such JJ cord-005453-4057qib7 1230 29 as as IN cord-005453-4057qib7 1230 30 pp65 pp65 NNP cord-005453-4057qib7 1230 31 and and CC cord-005453-4057qib7 1230 32 IE1 ie1 NN cord-005453-4057qib7 1230 33 , , , cord-005453-4057qib7 1230 34 and and CC cord-005453-4057qib7 1230 35 consequently consequently RB cord-005453-4057qib7 1230 36 WT1specific wt1specific JJ cord-005453-4057qib7 1230 37 CTLs ctl NNS cord-005453-4057qib7 1230 38 could could MD cord-005453-4057qib7 1230 39 be be VB cord-005453-4057qib7 1230 40 induced induce VBN cord-005453-4057qib7 1230 41 . . . cord-005453-4057qib7 1231 1 Moreover moreover RB cord-005453-4057qib7 1231 2 , , , cord-005453-4057qib7 1231 3 CTLs CTLs NNP cord-005453-4057qib7 1231 4 induced induce VBD cord-005453-4057qib7 1231 5 activated activate VBN cord-005453-4057qib7 1231 6 B B NNP cord-005453-4057qib7 1231 7 cells cell NNS cord-005453-4057qib7 1231 8 had have VBD cord-005453-4057qib7 1231 9 ability ability NN cord-005453-4057qib7 1231 10 to to TO cord-005453-4057qib7 1231 11 recognize recognize VB cord-005453-4057qib7 1231 12 and and CC cord-005453-4057qib7 1231 13 kill kill VB cord-005453-4057qib7 1231 14 the the DT cord-005453-4057qib7 1231 15 target target NN cord-005453-4057qib7 1231 16 cells cell NNS cord-005453-4057qib7 1231 17 expressing express VBG cord-005453-4057qib7 1231 18 WT1 wt1 WP cord-005453-4057qib7 1231 19 correctly correctly RB cord-005453-4057qib7 1231 20 . . . cord-005453-4057qib7 1232 1 Our -PRON- PRP$ cord-005453-4057qib7 1232 2 results result NNS cord-005453-4057qib7 1232 3 demonstrate demonstrate VBP cord-005453-4057qib7 1232 4 that that IN cord-005453-4057qib7 1232 5 these these DT cord-005453-4057qib7 1232 6 in in IN cord-005453-4057qib7 1232 7 vitro vitro FW cord-005453-4057qib7 1232 8 expanded expand VBD cord-005453-4057qib7 1232 9 WT1-specific wt1-specific CD cord-005453-4057qib7 1232 10 CTLs ctl NNS cord-005453-4057qib7 1232 11 using use VBG cord-005453-4057qib7 1232 12 activated activate VBN cord-005453-4057qib7 1232 13 B b NN cord-005453-4057qib7 1232 14 cells cell NNS cord-005453-4057qib7 1232 15 can can MD cord-005453-4057qib7 1232 16 be be VB cord-005453-4057qib7 1232 17 a a DT cord-005453-4057qib7 1232 18 promising promising JJ cord-005453-4057qib7 1232 19 candidate candidate NN cord-005453-4057qib7 1232 20 for for IN cord-005453-4057qib7 1232 21 adoptive adoptive JJ cord-005453-4057qib7 1232 22 immunotherapy immunotherapy NN cord-005453-4057qib7 1232 23 against against IN cord-005453-4057qib7 1232 24 cancer cancer NN cord-005453-4057qib7 1232 25 . . . cord-005453-4057qib7 1233 1 Disclosure disclosure NN cord-005453-4057qib7 1233 2 : : : cord-005453-4057qib7 1233 3 Nothing nothing NN cord-005453-4057qib7 1233 4 to to TO cord-005453-4057qib7 1233 5 declare declare VB cord-005453-4057qib7 1233 6 Judith Judith NNP cord-005453-4057qib7 1233 7 Böhringer Böhringer NNP cord-005453-4057qib7 1233 8 1 1 CD cord-005453-4057qib7 1233 9 , , , cord-005453-4057qib7 1233 10 Michael Michael NNP cord-005453-4057qib7 1233 11 Schumm Schumm NNP cord-005453-4057qib7 1233 12 1 1 CD cord-005453-4057qib7 1233 13 , , , cord-005453-4057qib7 1233 14 Christiane Christiane NNP cord-005453-4057qib7 1233 15 Braun Braun NNP cord-005453-4057qib7 1233 16 1 1 CD cord-005453-4057qib7 1233 17 , , , cord-005453-4057qib7 1233 18 Marina Marina NNP cord-005453-4057qib7 1233 19 Schmidt Schmidt NNP cord-005453-4057qib7 1233 20 1 1 CD cord-005453-4057qib7 1233 21 , , , cord-005453-4057qib7 1233 22 Patrick Patrick NNP cord-005453-4057qib7 1233 23 Schlegel Schlegel NNP cord-005453-4057qib7 1233 24 1 1 CD cord-005453-4057qib7 1233 25 , , , cord-005453-4057qib7 1233 26 Christian Christian NNP cord-005453-4057qib7 1233 27 Seitz Seitz NNP cord-005453-4057qib7 1233 28 1 1 CD cord-005453-4057qib7 1233 29 , , , cord-005453-4057qib7 1233 30 Murat Murat NNP cord-005453-4057qib7 1233 31 Aktas Aktas NNP cord-005453-4057qib7 1233 32 2 2 CD cord-005453-4057qib7 1233 33 , , , cord-005453-4057qib7 1233 34 Georg Georg NNP cord-005453-4057qib7 1233 35 Rauser Rauser NNP cord-005453-4057qib7 1233 36 2 2 CD cord-005453-4057qib7 1233 37 , , , cord-005453-4057qib7 1233 38 Sandra Sandra NNP cord-005453-4057qib7 1233 39 Karitzky Karitzky NNP cord-005453-4057qib7 1233 40 2 2 CD cord-005453-4057qib7 1233 41 , , , cord-005453-4057qib7 1233 42 Peter Peter NNP cord-005453-4057qib7 1233 43 Lang Lang NNP cord-005453-4057qib7 1233 44 1 1 CD cord-005453-4057qib7 1234 1 , , , cord-005453-4057qib7 1234 2 Rupert Rupert NNP cord-005453-4057qib7 1234 3 Handgretinger Handgretinger NNP cord-005453-4057qib7 1234 4 1 1 CD cord-005453-4057qib7 1234 5 1 1 CD cord-005453-4057qib7 1234 6 University University NNP cord-005453-4057qib7 1234 7 Children Children NNPS cord-005453-4057qib7 1234 8 's 's POS cord-005453-4057qib7 1234 9 Hospital Hospital NNP cord-005453-4057qib7 1234 10 Tübingen Tübingen NNP cord-005453-4057qib7 1234 11 , , , cord-005453-4057qib7 1234 12 Tübingen Tübingen NNP cord-005453-4057qib7 1234 13 , , , cord-005453-4057qib7 1234 14 Germany Germany NNP cord-005453-4057qib7 1234 15 , , , cord-005453-4057qib7 1234 16 2 2 CD cord-005453-4057qib7 1234 17 Miltenyi Miltenyi NNP cord-005453-4057qib7 1234 18 Biotec Biotec NNP cord-005453-4057qib7 1234 19 GmbH GmbH NNP cord-005453-4057qib7 1234 20 , , , cord-005453-4057qib7 1234 21 Bergisch Bergisch NNP cord-005453-4057qib7 1234 22 Gladbach Gladbach NNP cord-005453-4057qib7 1234 23 , , , cord-005453-4057qib7 1234 24 Germany Germany NNP cord-005453-4057qib7 1234 25 Background Background NNP cord-005453-4057qib7 1234 26 : : : cord-005453-4057qib7 1234 27 T t NN cord-005453-4057qib7 1234 28 cells cell NNS cord-005453-4057qib7 1234 29 with with IN cord-005453-4057qib7 1234 30 chimeric chimeric JJ cord-005453-4057qib7 1234 31 antigen antigen NN cord-005453-4057qib7 1234 32 receptors receptor NNS cord-005453-4057qib7 1234 33 ( ( -LRB- cord-005453-4057qib7 1234 34 CARs car NNS cord-005453-4057qib7 1234 35 ) ) -RRB- cord-005453-4057qib7 1234 36 on on IN cord-005453-4057qib7 1234 37 their -PRON- PRP$ cord-005453-4057qib7 1234 38 surface surface NN cord-005453-4057qib7 1234 39 facilitate facilitate VBP cord-005453-4057qib7 1234 40 to to TO cord-005453-4057qib7 1234 41 target target VB cord-005453-4057qib7 1234 42 specific specific JJ cord-005453-4057qib7 1234 43 surface surface NN cord-005453-4057qib7 1234 44 expressed express VBD cord-005453-4057qib7 1234 45 antigens antigen NNS cord-005453-4057qib7 1234 46 . . . cord-005453-4057qib7 1235 1 Research research NN cord-005453-4057qib7 1235 2 and and CC cord-005453-4057qib7 1235 3 clinical clinical JJ cord-005453-4057qib7 1235 4 trials trial NNS cord-005453-4057qib7 1235 5 with with IN cord-005453-4057qib7 1235 6 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 1235 7 T T NNP cord-005453-4057qib7 1235 8 cells cell NNS cord-005453-4057qib7 1235 9 show show VBP cord-005453-4057qib7 1235 10 impressive impressive JJ cord-005453-4057qib7 1235 11 remission remission NN cord-005453-4057qib7 1235 12 induction induction NN cord-005453-4057qib7 1235 13 rates rate NNS cord-005453-4057qib7 1235 14 and and CC cord-005453-4057qib7 1235 15 increased increase VBN cord-005453-4057qib7 1235 16 survival survival NN cord-005453-4057qib7 1235 17 in in IN cord-005453-4057qib7 1235 18 heavily heavily RB cord-005453-4057qib7 1235 19 pretreated pretreate VBN cord-005453-4057qib7 1235 20 patients patient NNS cord-005453-4057qib7 1235 21 . . . cord-005453-4057qib7 1236 1 Therefore therefore RB cord-005453-4057qib7 1236 2 , , , cord-005453-4057qib7 1236 3 CAR car NN cord-005453-4057qib7 1236 4 T t NN cord-005453-4057qib7 1236 5 cells cell NNS cord-005453-4057qib7 1236 6 are be VBP cord-005453-4057qib7 1236 7 introduced introduce VBN cord-005453-4057qib7 1236 8 as as IN cord-005453-4057qib7 1236 9 new new JJ cord-005453-4057qib7 1236 10 potent potent JJ cord-005453-4057qib7 1236 11 cellular cellular JJ cord-005453-4057qib7 1236 12 therapeutics therapeutic NNS cord-005453-4057qib7 1236 13 in in IN cord-005453-4057qib7 1236 14 the the DT cord-005453-4057qib7 1236 15 clinical clinical JJ cord-005453-4057qib7 1236 16 routine routine NN cord-005453-4057qib7 1236 17 . . . cord-005453-4057qib7 1237 1 In in IN cord-005453-4057qib7 1237 2 order order NN cord-005453-4057qib7 1237 3 to to TO cord-005453-4057qib7 1237 4 establish establish VB cord-005453-4057qib7 1237 5 the the DT cord-005453-4057qib7 1237 6 manufacture manufacture NN cord-005453-4057qib7 1237 7 of of IN cord-005453-4057qib7 1237 8 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 1237 9 T T NNP cord-005453-4057qib7 1237 10 cells cell NNS cord-005453-4057qib7 1237 11 , , , cord-005453-4057qib7 1237 12 validation validation NN cord-005453-4057qib7 1237 13 runs run VBZ cord-005453-4057qib7 1237 14 with with IN cord-005453-4057qib7 1237 15 the the DT cord-005453-4057qib7 1237 16 fully fully RB cord-005453-4057qib7 1237 17 automated automate VBN cord-005453-4057qib7 1237 18 CliniMACS CliniMACS NNP cord-005453-4057qib7 1237 19 Prodigy Prodigy NNP cord-005453-4057qib7 1237 20 T T NNP cord-005453-4057qib7 1237 21 cell cell NN cord-005453-4057qib7 1237 22 transduction transduction NN cord-005453-4057qib7 1237 23 process process NN cord-005453-4057qib7 1237 24 have have VBP cord-005453-4057qib7 1237 25 been be VBN cord-005453-4057qib7 1237 26 performed perform VBN cord-005453-4057qib7 1237 27 using use VBG cord-005453-4057qib7 1237 28 the the DT cord-005453-4057qib7 1237 29 Miltenyi Miltenyi NNP cord-005453-4057qib7 1237 30 anti anti JJ cord-005453-4057qib7 1237 31 - - JJ cord-005453-4057qib7 1237 32 CD19-CAR cd19-car JJ cord-005453-4057qib7 1237 33 lentiviral lentiviral JJ cord-005453-4057qib7 1237 34 vector vector NN cord-005453-4057qib7 1237 35 . . . cord-005453-4057qib7 1238 1 Methods method NNS cord-005453-4057qib7 1238 2 : : : cord-005453-4057qib7 1239 1 Unmobilized unmobilized JJ cord-005453-4057qib7 1239 2 leukaphereses leukapherese VBZ cord-005453-4057qib7 1239 3 from from IN cord-005453-4057qib7 1239 4 3 3 CD cord-005453-4057qib7 1239 5 donors donor NNS cord-005453-4057qib7 1239 6 ( ( -LRB- cord-005453-4057qib7 1239 7 2 2 CD cord-005453-4057qib7 1239 8 x x SYM cord-005453-4057qib7 1239 9 healthy healthy JJ cord-005453-4057qib7 1239 10 , , , cord-005453-4057qib7 1239 11 1 1 CD cord-005453-4057qib7 1239 12 x x NN cord-005453-4057qib7 1239 13 ALL all DT cord-005453-4057qib7 1239 14 ) ) -RRB- cord-005453-4057qib7 1239 15 were be VBD cord-005453-4057qib7 1239 16 used use VBN cord-005453-4057qib7 1239 17 for for IN cord-005453-4057qib7 1239 18 the the DT cord-005453-4057qib7 1239 19 CliniMACS CliniMACS NNP cord-005453-4057qib7 1239 20 Prodigy Prodigy NNP cord-005453-4057qib7 1239 21 T T NNP cord-005453-4057qib7 1239 22 cell cell NN cord-005453-4057qib7 1239 23 transduction transduction NN cord-005453-4057qib7 1239 24 process process NN cord-005453-4057qib7 1239 25 . . . cord-005453-4057qib7 1240 1 Leukocytes leukocyte NNS cord-005453-4057qib7 1240 2 undergo undergo VBP cord-005453-4057qib7 1240 3 a a DT cord-005453-4057qib7 1240 4 CD4 CD4 NNP cord-005453-4057qib7 1240 5 + + CC cord-005453-4057qib7 1240 6 / / SYM cord-005453-4057qib7 1240 7 CD8 CD8 NNP cord-005453-4057qib7 1240 8 + + CC cord-005453-4057qib7 1240 9 T T NNP cord-005453-4057qib7 1240 10 cell cell NN cord-005453-4057qib7 1240 11 enrichment enrichment NN cord-005453-4057qib7 1240 12 via via IN cord-005453-4057qib7 1240 13 magnetic magnetic JJ cord-005453-4057qib7 1240 14 beads bead NNS cord-005453-4057qib7 1240 15 , , , cord-005453-4057qib7 1240 16 followed follow VBN cord-005453-4057qib7 1240 17 by by IN cord-005453-4057qib7 1240 18 stimulation stimulation NN cord-005453-4057qib7 1240 19 with with IN cord-005453-4057qib7 1240 20 MACS mac NNS cord-005453-4057qib7 1241 1 ® ® , cord-005453-4057qib7 1241 2 GMP GMP NNP cord-005453-4057qib7 1241 3 T T NNP cord-005453-4057qib7 1241 4 cell cell NN cord-005453-4057qib7 1241 5 TransAct TransAct NNP cord-005453-4057qib7 1241 6 ™ ™ NN cord-005453-4057qib7 1241 7 , , , cord-005453-4057qib7 1241 8 transduction transduction NN cord-005453-4057qib7 1241 9 with with IN cord-005453-4057qib7 1241 10 an an DT cord-005453-4057qib7 1241 11 anti anti JJ cord-005453-4057qib7 1241 12 - - JJ cord-005453-4057qib7 1241 13 CD19-CAR cd19-car JJ cord-005453-4057qib7 1241 14 lentiviral lentiviral JJ cord-005453-4057qib7 1241 15 vector vector NN cord-005453-4057qib7 1241 16 , , , cord-005453-4057qib7 1241 17 expansion expansion NN cord-005453-4057qib7 1241 18 with with IN cord-005453-4057qib7 1241 19 IL7 IL7 NNS cord-005453-4057qib7 1241 20 and and CC cord-005453-4057qib7 1241 21 IL15 IL15 NNP cord-005453-4057qib7 1241 22 , , , cord-005453-4057qib7 1241 23 and and CC cord-005453-4057qib7 1241 24 final final JJ cord-005453-4057qib7 1241 25 formulation formulation NN cord-005453-4057qib7 1241 26 to to IN cord-005453-4057qib7 1241 27 the the DT cord-005453-4057qib7 1241 28 cellular cellular JJ cord-005453-4057qib7 1241 29 product product NN cord-005453-4057qib7 1241 30 . . . cord-005453-4057qib7 1242 1 During during IN cord-005453-4057qib7 1242 2 and and CC cord-005453-4057qib7 1242 3 after after IN cord-005453-4057qib7 1242 4 the the DT cord-005453-4057qib7 1242 5 manufacture manufacture NN cord-005453-4057qib7 1242 6 , , , cord-005453-4057qib7 1242 7 FACS FACS NNP cord-005453-4057qib7 1242 8 analyses analysis NNS cord-005453-4057qib7 1242 9 were be VBD cord-005453-4057qib7 1242 10 performed perform VBN cord-005453-4057qib7 1242 11 as as RB cord-005453-4057qib7 1242 12 well well RB cord-005453-4057qib7 1242 13 as as IN cord-005453-4057qib7 1242 14 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1242 15 assays assay NNS cord-005453-4057qib7 1242 16 after after IN cord-005453-4057qib7 1242 17 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 1242 18 T t NN cord-005453-4057qib7 1242 19 cell cell NN cord-005453-4057qib7 1242 20 production production NN cord-005453-4057qib7 1242 21 . . . cord-005453-4057qib7 1243 1 Results result NNS cord-005453-4057qib7 1243 2 : : : cord-005453-4057qib7 1244 1 Total total JJ cord-005453-4057qib7 1244 2 volumes volume NNS cord-005453-4057qib7 1244 3 of of IN cord-005453-4057qib7 1244 4 leukaphereses leukapherese NNS cord-005453-4057qib7 1244 5 were be VBD cord-005453-4057qib7 1244 6 between between IN cord-005453-4057qib7 1244 7 60 60 CD cord-005453-4057qib7 1244 8 and and CC cord-005453-4057qib7 1244 9 280 280 CD cord-005453-4057qib7 1244 10 ml ml NN cord-005453-4057qib7 1244 11 with with IN cord-005453-4057qib7 1244 12 2.6 2.6 CD cord-005453-4057qib7 1244 13 -4.0 -4.0 NNP cord-005453-4057qib7 1244 14 x x SYM cord-005453-4057qib7 1244 15 10 10 CD cord-005453-4057qib7 1244 16 9 9 CD cord-005453-4057qib7 1244 17 total total JJ cord-005453-4057qib7 1244 18 mononuclear mononuclear JJ cord-005453-4057qib7 1244 19 cells cell NNS cord-005453-4057qib7 1244 20 . . . cord-005453-4057qib7 1245 1 After after IN cord-005453-4057qib7 1245 2 enrichment enrichment NN cord-005453-4057qib7 1245 3 100x10 100x10 CD cord-005453-4057qib7 1245 4 6 6 CD cord-005453-4057qib7 1245 5 CD4 CD4 NNS cord-005453-4057qib7 1245 6 + + CC cord-005453-4057qib7 1245 7 / / SYM cord-005453-4057qib7 1245 8 CD8 CD8 NNP cord-005453-4057qib7 1245 9 + + CC cord-005453-4057qib7 1245 10 T t NN cord-005453-4057qib7 1245 11 cells cell NNS cord-005453-4057qib7 1245 12 were be VBD cord-005453-4057qib7 1245 13 transduced transduce VBN cord-005453-4057qib7 1245 14 with with IN cord-005453-4057qib7 1245 15 anti anti JJ cord-005453-4057qib7 1245 16 - - JJ cord-005453-4057qib7 1245 17 CD19-CAR cd19-car JJ cord-005453-4057qib7 1245 18 lentiviral lentiviral JJ cord-005453-4057qib7 1245 19 vector vector NN cord-005453-4057qib7 1245 20 and and CC cord-005453-4057qib7 1245 21 were be VBD cord-005453-4057qib7 1245 22 further further RB cord-005453-4057qib7 1245 23 expanded expand VBN cord-005453-4057qib7 1245 24 . . . cord-005453-4057qib7 1246 1 Cells cell NNS cord-005453-4057qib7 1246 2 were be VBD cord-005453-4057qib7 1246 3 harvested harvest VBN cord-005453-4057qib7 1246 4 on on IN cord-005453-4057qib7 1246 5 day day NN cord-005453-4057qib7 1246 6 12 12 CD cord-005453-4057qib7 1246 7 . . . cord-005453-4057qib7 1247 1 The the DT cord-005453-4057qib7 1247 2 final final JJ cord-005453-4057qib7 1247 3 cell cell NN cord-005453-4057qib7 1247 4 counts count NNS cord-005453-4057qib7 1247 5 of of IN cord-005453-4057qib7 1247 6 the the DT cord-005453-4057qib7 1247 7 cellular cellular JJ cord-005453-4057qib7 1247 8 products product NNS cord-005453-4057qib7 1247 9 were be VBD cord-005453-4057qib7 1247 10 6.1 6.1 CD cord-005453-4057qib7 1247 11 , , , cord-005453-4057qib7 1247 12 7.2 7.2 CD cord-005453-4057qib7 1247 13 and and CC cord-005453-4057qib7 1247 14 5.0 5.0 CD cord-005453-4057qib7 1247 15 x x SYM cord-005453-4057qib7 1247 16 10 10 CD cord-005453-4057qib7 1247 17 9 9 CD cord-005453-4057qib7 1247 18 mononuclear mononuclear NN cord-005453-4057qib7 1247 19 cells cell NNS cord-005453-4057qib7 1247 20 from from IN cord-005453-4057qib7 1247 21 two two CD cord-005453-4057qib7 1247 22 healthy healthy JJ cord-005453-4057qib7 1247 23 volunteers volunteer NNS cord-005453-4057qib7 1247 24 and and CC cord-005453-4057qib7 1247 25 the the DT cord-005453-4057qib7 1247 26 ALL all RB cord-005453-4057qib7 1247 27 - - HYPH cord-005453-4057qib7 1247 28 patient patient JJ cord-005453-4057qib7 1247 29 , , , cord-005453-4057qib7 1247 30 respectively respectively RB cord-005453-4057qib7 1247 31 . . . cord-005453-4057qib7 1248 1 The the DT cord-005453-4057qib7 1248 2 transduction transduction NN cord-005453-4057qib7 1248 3 efficiency efficiency NN cord-005453-4057qib7 1248 4 of of IN cord-005453-4057qib7 1248 5 the the DT cord-005453-4057qib7 1248 6 CD19-CAR cd19-car JJ cord-005453-4057qib7 1248 7 T T NNP cord-005453-4057qib7 1248 8 cells cell NNS cord-005453-4057qib7 1248 9 was be VBD cord-005453-4057qib7 1248 10 48.6 48.6 CD cord-005453-4057qib7 1248 11 % % NN cord-005453-4057qib7 1248 12 , , , cord-005453-4057qib7 1248 13 43.4 43.4 CD cord-005453-4057qib7 1248 14 % % NN cord-005453-4057qib7 1248 15 and and CC cord-005453-4057qib7 1248 16 32.0 32.0 CD cord-005453-4057qib7 1248 17 % % NN cord-005453-4057qib7 1248 18 among among IN cord-005453-4057qib7 1248 19 viable viable JJ cord-005453-4057qib7 1248 20 CD3 CD3 NNP cord-005453-4057qib7 1248 21 + + CC cord-005453-4057qib7 1248 22 cells cell NNS cord-005453-4057qib7 1248 23 . . . cord-005453-4057qib7 1249 1 The the DT cord-005453-4057qib7 1249 2 final final JJ cord-005453-4057qib7 1249 3 count count NN cord-005453-4057qib7 1249 4 of of IN cord-005453-4057qib7 1249 5 CAR CAR NNP cord-005453-4057qib7 1249 6 T t NN cord-005453-4057qib7 1249 7 cells cell NNS cord-005453-4057qib7 1249 8 was be VBD cord-005453-4057qib7 1249 9 therefore therefore RB cord-005453-4057qib7 1249 10 2.9 2.9 CD cord-005453-4057qib7 1249 11 , , , cord-005453-4057qib7 1249 12 3.0 3.0 CD cord-005453-4057qib7 1249 13 and and CC cord-005453-4057qib7 1249 14 1.5 1.5 CD cord-005453-4057qib7 1249 15 x x SYM cord-005453-4057qib7 1249 16 10 10 CD cord-005453-4057qib7 1249 17 9 9 CD cord-005453-4057qib7 1249 18 cells cell NNS cord-005453-4057qib7 1249 19 . . . cord-005453-4057qib7 1250 1 The the DT cord-005453-4057qib7 1250 2 final final JJ cord-005453-4057qib7 1250 3 products product NNS cord-005453-4057qib7 1250 4 exerted exert VBD cord-005453-4057qib7 1250 5 excellent excellent JJ cord-005453-4057qib7 1250 6 cytolytic cytolytic JJ cord-005453-4057qib7 1250 7 activity activity NN cord-005453-4057qib7 1250 8 against against IN cord-005453-4057qib7 1250 9 CD19 CD19 NNP cord-005453-4057qib7 1250 10 + + CC cord-005453-4057qib7 1250 11 BCP BCP NNP cord-005453-4057qib7 1250 12 - - : cord-005453-4057qib7 1250 13 ALL all DT cord-005453-4057qib7 1250 14 cell cell NN cord-005453-4057qib7 1250 15 line line NN cord-005453-4057qib7 1250 16 NALM-6 NALM-6 NNP cord-005453-4057qib7 1250 17 . . . cord-005453-4057qib7 1251 1 Importantly importantly RB cord-005453-4057qib7 1251 2 , , , cord-005453-4057qib7 1251 3 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 1251 4 T t NN cord-005453-4057qib7 1251 5 cells cell NNS cord-005453-4057qib7 1251 6 generated generate VBN cord-005453-4057qib7 1251 7 from from IN cord-005453-4057qib7 1251 8 the the DT cord-005453-4057qib7 1251 9 ALL all DT cord-005453-4057qib7 1251 10 patient patient NN cord-005453-4057qib7 1251 11 demonstrated demonstrate VBD cord-005453-4057qib7 1251 12 complete complete JJ cord-005453-4057qib7 1251 13 eradication eradication NN cord-005453-4057qib7 1251 14 of of IN cord-005453-4057qib7 1251 15 autologous autologous JJ cord-005453-4057qib7 1251 16 blasts blast NNS cord-005453-4057qib7 1251 17 at at IN cord-005453-4057qib7 1251 18 0.3 0.3 CD cord-005453-4057qib7 1251 19 to to TO cord-005453-4057qib7 1251 20 1 1 CD cord-005453-4057qib7 1251 21 E e NN cord-005453-4057qib7 1251 22 : : : cord-005453-4057qib7 1251 23 T t NN cord-005453-4057qib7 1251 24 ratio ratio NN cord-005453-4057qib7 1251 25 after after IN cord-005453-4057qib7 1251 26 24 24 CD cord-005453-4057qib7 1251 27 hours hour NNS cord-005453-4057qib7 1251 28 incubation incubation NN cord-005453-4057qib7 1251 29 . . . cord-005453-4057qib7 1252 1 Conclusions conclusion NNS cord-005453-4057qib7 1252 2 : : : cord-005453-4057qib7 1253 1 The the DT cord-005453-4057qib7 1253 2 CliniMACS CliniMACS NNP cord-005453-4057qib7 1253 3 Prodigy Prodigy NNP cord-005453-4057qib7 1253 4 T T NNP cord-005453-4057qib7 1253 5 cell cell NN cord-005453-4057qib7 1253 6 transduction transduction NN cord-005453-4057qib7 1253 7 process process NN cord-005453-4057qib7 1253 8 has have VBZ cord-005453-4057qib7 1253 9 been be VBN cord-005453-4057qib7 1253 10 shown show VBN cord-005453-4057qib7 1253 11 to to TO cord-005453-4057qib7 1253 12 run run VB cord-005453-4057qib7 1253 13 a a DT cord-005453-4057qib7 1253 14 fully fully RB cord-005453-4057qib7 1253 15 - - HYPH cord-005453-4057qib7 1253 16 automated automate VBN cord-005453-4057qib7 1253 17 manufacturing manufacturing NN cord-005453-4057qib7 1253 18 process process NN cord-005453-4057qib7 1253 19 over over IN cord-005453-4057qib7 1253 20 12 12 CD cord-005453-4057qib7 1253 21 days day NNS cord-005453-4057qib7 1253 22 without without IN cord-005453-4057qib7 1253 23 any any DT cord-005453-4057qib7 1253 24 deviations deviation NNS cord-005453-4057qib7 1253 25 in in IN cord-005453-4057qib7 1253 26 a a DT cord-005453-4057qib7 1253 27 clean clean JJ cord-005453-4057qib7 1253 28 room room NN cord-005453-4057qib7 1253 29 environment environment NN cord-005453-4057qib7 1253 30 on on IN cord-005453-4057qib7 1253 31 a a DT cord-005453-4057qib7 1253 32 single single JJ cord-005453-4057qib7 1253 33 device device NN cord-005453-4057qib7 1253 34 . . . cord-005453-4057qib7 1254 1 The the DT cord-005453-4057qib7 1254 2 user user NN cord-005453-4057qib7 1254 3 interaction interaction NN cord-005453-4057qib7 1254 4 was be VBD cord-005453-4057qib7 1254 5 reduced reduce VBN cord-005453-4057qib7 1254 6 to to IN cord-005453-4057qib7 1254 7 activities activity NNS cord-005453-4057qib7 1254 8 at at IN cord-005453-4057qib7 1254 9 only only RB cord-005453-4057qib7 1254 10 3 3 CD cord-005453-4057qib7 1254 11 days day NNS cord-005453-4057qib7 1254 12 to to TO cord-005453-4057qib7 1254 13 set set VB cord-005453-4057qib7 1254 14 up up RP cord-005453-4057qib7 1254 15 the the DT cord-005453-4057qib7 1254 16 system system NN cord-005453-4057qib7 1254 17 and and CC cord-005453-4057qib7 1254 18 provide provide VB cord-005453-4057qib7 1254 19 fresh fresh JJ cord-005453-4057qib7 1254 20 medium medium NN cord-005453-4057qib7 1254 21 and and CC cord-005453-4057qib7 1254 22 reagents reagent NNS cord-005453-4057qib7 1254 23 . . . cord-005453-4057qib7 1255 1 The the DT cord-005453-4057qib7 1255 2 transduction transduction NN cord-005453-4057qib7 1255 3 process process NN cord-005453-4057qib7 1255 4 yielded yield VBD cord-005453-4057qib7 1255 5 a a DT cord-005453-4057qib7 1255 6 high high JJ cord-005453-4057qib7 1255 7 number number NN cord-005453-4057qib7 1255 8 of of IN cord-005453-4057qib7 1255 9 T t NN cord-005453-4057qib7 1255 10 cells cell NNS cord-005453-4057qib7 1255 11 with with IN cord-005453-4057qib7 1255 12 a a DT cord-005453-4057qib7 1255 13 high high JJ cord-005453-4057qib7 1255 14 frequency frequency NN cord-005453-4057qib7 1255 15 of of IN cord-005453-4057qib7 1255 16 CD19-CAR cd19-car JJ cord-005453-4057qib7 1255 17 T T NNP cord-005453-4057qib7 1255 18 transduced transduce VBD cord-005453-4057qib7 1255 19 cells cell NNS cord-005453-4057qib7 1255 20 . . . cord-005453-4057qib7 1256 1 The the DT cord-005453-4057qib7 1256 2 results result NNS cord-005453-4057qib7 1256 3 were be VBD cord-005453-4057qib7 1256 4 comparable comparable JJ cord-005453-4057qib7 1256 5 for for IN cord-005453-4057qib7 1256 6 both both DT cord-005453-4057qib7 1256 7 unmobilized unmobilized JJ cord-005453-4057qib7 1256 8 leukaphereses leukapherese NNS cord-005453-4057qib7 1256 9 from from IN cord-005453-4057qib7 1256 10 healthy healthy JJ cord-005453-4057qib7 1256 11 donors donor NNS cord-005453-4057qib7 1256 12 and and CC cord-005453-4057qib7 1256 13 showed show VBD cord-005453-4057qib7 1256 14 expected expect VBN cord-005453-4057qib7 1256 15 slightly slightly RB cord-005453-4057qib7 1256 16 lower low JJR cord-005453-4057qib7 1256 17 results result NNS cord-005453-4057qib7 1256 18 in in IN cord-005453-4057qib7 1256 19 the the DT cord-005453-4057qib7 1256 20 patient patient NN cord-005453-4057qib7 1256 21 . . . cord-005453-4057qib7 1257 1 Finally finally RB cord-005453-4057qib7 1257 2 , , , cord-005453-4057qib7 1257 3 these these DT cord-005453-4057qib7 1257 4 results result NNS cord-005453-4057qib7 1257 5 demonstrate demonstrate VBP cord-005453-4057qib7 1257 6 that that IN cord-005453-4057qib7 1257 7 the the DT cord-005453-4057qib7 1257 8 CliniMACS CliniMACS NNP cord-005453-4057qib7 1257 9 Prodigy Prodigy NNP cord-005453-4057qib7 1257 10 T T NNP cord-005453-4057qib7 1257 11 cell cell NN cord-005453-4057qib7 1257 12 transduction transduction NN cord-005453-4057qib7 1257 13 process process NN cord-005453-4057qib7 1257 14 is be VBZ cord-005453-4057qib7 1257 15 well well RB cord-005453-4057qib7 1257 16 suited suited JJ cord-005453-4057qib7 1257 17 to to TO cord-005453-4057qib7 1257 18 provide provide VB cord-005453-4057qib7 1257 19 the the DT cord-005453-4057qib7 1257 20 clinical clinical JJ cord-005453-4057qib7 1257 21 MB mb NN cord-005453-4057qib7 1257 22 - - HYPH cord-005453-4057qib7 1257 23 CART19.1 CART19.1 NNP cord-005453-4057qib7 1257 24 r r NN cord-005453-4057qib7 1257 25 / / SYM cord-005453-4057qib7 1257 26 r r NN cord-005453-4057qib7 1257 27 CD19 CD19 NNP cord-005453-4057qib7 1257 28 + + CC cord-005453-4057qib7 1257 29 BCM bcm NN cord-005453-4057qib7 1257 30 study study NN cord-005453-4057qib7 1257 31 with with IN cord-005453-4057qib7 1257 32 appropriate appropriate JJ cord-005453-4057qib7 1257 33 investigational investigational JJ cord-005453-4057qib7 1257 34 medical medical JJ cord-005453-4057qib7 1257 35 products product NNS cord-005453-4057qib7 1257 36 . . . cord-005453-4057qib7 1258 1 Disclosure disclosure NN cord-005453-4057qib7 1258 2 Background background NN cord-005453-4057qib7 1258 3 : : : cord-005453-4057qib7 1259 1 Allogeneic allogeneic IN cord-005453-4057qib7 1259 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 1259 3 stem stem NN cord-005453-4057qib7 1259 4 cell cell NN cord-005453-4057qib7 1259 5 transplantation transplantation NN cord-005453-4057qib7 1259 6 ( ( -LRB- cord-005453-4057qib7 1259 7 alloHCT alloHCT NNP cord-005453-4057qib7 1259 8 ) ) -RRB- cord-005453-4057qib7 1259 9 is be VBZ cord-005453-4057qib7 1259 10 an an DT cord-005453-4057qib7 1259 11 effective effective JJ cord-005453-4057qib7 1259 12 strategy strategy NN cord-005453-4057qib7 1259 13 in in IN cord-005453-4057qib7 1259 14 the the DT cord-005453-4057qib7 1259 15 long long JJ cord-005453-4057qib7 1259 16 term term NN cord-005453-4057qib7 1259 17 control control NN cord-005453-4057qib7 1259 18 of of IN cord-005453-4057qib7 1259 19 several several JJ cord-005453-4057qib7 1259 20 hematologic hematologic JJ cord-005453-4057qib7 1259 21 diseases disease NNS cord-005453-4057qib7 1259 22 , , , cord-005453-4057qib7 1259 23 however however RB cord-005453-4057qib7 1259 24 , , , cord-005453-4057qib7 1259 25 patients patient NNS cord-005453-4057qib7 1259 26 could could MD cord-005453-4057qib7 1259 27 experience experience VB cord-005453-4057qib7 1259 28 complications complication NNS cord-005453-4057qib7 1259 29 , , , cord-005453-4057qib7 1259 30 as as IN cord-005453-4057qib7 1259 31 graft graft NN cord-005453-4057qib7 1259 32 versus versus IN cord-005453-4057qib7 1259 33 host host NN cord-005453-4057qib7 1259 34 disease disease NN cord-005453-4057qib7 1259 35 ( ( -LRB- cord-005453-4057qib7 1259 36 GVHD GVHD NNP cord-005453-4057qib7 1259 37 ) ) -RRB- cord-005453-4057qib7 1259 38 and and CC cord-005453-4057qib7 1259 39 disease disease NN cord-005453-4057qib7 1259 40 relapse relapse NN cord-005453-4057qib7 1259 41 . . . cord-005453-4057qib7 1260 1 Recently recently RB cord-005453-4057qib7 1260 2 , , , cord-005453-4057qib7 1260 3 the the DT cord-005453-4057qib7 1260 4 introduction introduction NN cord-005453-4057qib7 1260 5 of of IN cord-005453-4057qib7 1260 6 post post JJ cord-005453-4057qib7 1260 7 - - JJ cord-005453-4057qib7 1260 8 transplant transplant NN cord-005453-4057qib7 1260 9 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 1260 10 ( ( -LRB- cord-005453-4057qib7 1260 11 ptCy ptcy RB cord-005453-4057qib7 1260 12 ) ) -RRB- cord-005453-4057qib7 1260 13 allowed allow VBN cord-005453-4057qib7 1260 14 to to TO cord-005453-4057qib7 1260 15 significantly significantly RB cord-005453-4057qib7 1260 16 reduce reduce VB cord-005453-4057qib7 1260 17 GVHD GVHD NNP cord-005453-4057qib7 1260 18 , , , cord-005453-4057qib7 1260 19 but but CC cord-005453-4057qib7 1260 20 disease disease NN cord-005453-4057qib7 1260 21 relapse relapse NN cord-005453-4057qib7 1260 22 remains remain VBZ cord-005453-4057qib7 1260 23 an an DT cord-005453-4057qib7 1260 24 important important JJ cord-005453-4057qib7 1260 25 issue issue NN cord-005453-4057qib7 1260 26 . . . cord-005453-4057qib7 1261 1 Donor donor NN cord-005453-4057qib7 1261 2 - - HYPH cord-005453-4057qib7 1261 3 lymphocyte lymphocyte NN cord-005453-4057qib7 1261 4 infusion infusion NN cord-005453-4057qib7 1261 5 ( ( -LRB- cord-005453-4057qib7 1261 6 DLI DLI NNP cord-005453-4057qib7 1261 7 ) ) -RRB- cord-005453-4057qib7 1261 8 is be VBZ cord-005453-4057qib7 1261 9 an an DT cord-005453-4057qib7 1261 10 established establish VBN cord-005453-4057qib7 1261 11 adoptive adoptive JJ cord-005453-4057qib7 1261 12 cell cell NN cord-005453-4057qib7 1261 13 therapy therapy NN cord-005453-4057qib7 1261 14 for for IN cord-005453-4057qib7 1261 15 disease disease NN cord-005453-4057qib7 1261 16 relapse relapse NN cord-005453-4057qib7 1261 17 after after IN cord-005453-4057qib7 1261 18 alloHSCT alloHSCT NNP cord-005453-4057qib7 1261 19 , , , cord-005453-4057qib7 1261 20 but but CC cord-005453-4057qib7 1261 21 , , , cord-005453-4057qib7 1261 22 in in IN cord-005453-4057qib7 1261 23 order order NN cord-005453-4057qib7 1261 24 to to TO cord-005453-4057qib7 1261 25 be be VB cord-005453-4057qib7 1261 26 efficient efficient JJ cord-005453-4057qib7 1261 27 and and CC cord-005453-4057qib7 1261 28 safe safe JJ cord-005453-4057qib7 1261 29 , , , cord-005453-4057qib7 1261 30 patients patient NNS cord-005453-4057qib7 1261 31 have have VBP cord-005453-4057qib7 1261 32 to to TO cord-005453-4057qib7 1261 33 be be VB cord-005453-4057qib7 1261 34 off off IN cord-005453-4057qib7 1261 35 immunosuppression immunosuppression NN cord-005453-4057qib7 1261 36 treatments treatment NNS cord-005453-4057qib7 1261 37 and and CC cord-005453-4057qib7 1261 38 GVDH GVDH NNP cord-005453-4057qib7 1261 39 - - HYPH cord-005453-4057qib7 1261 40 free free JJ cord-005453-4057qib7 1261 41 . . . cord-005453-4057qib7 1262 1 Here here RB cord-005453-4057qib7 1262 2 we -PRON- PRP cord-005453-4057qib7 1262 3 report report VBP cord-005453-4057qib7 1262 4 our -PRON- PRP$ cord-005453-4057qib7 1262 5 data datum NNS cord-005453-4057qib7 1262 6 about about IN cord-005453-4057qib7 1262 7 efficacy efficacy NN cord-005453-4057qib7 1262 8 and and CC cord-005453-4057qib7 1262 9 safety safety NN cord-005453-4057qib7 1262 10 of of IN cord-005453-4057qib7 1262 11 DLI DLI NNP cord-005453-4057qib7 1262 12 infusion infusion NN cord-005453-4057qib7 1262 13 as as IN cord-005453-4057qib7 1262 14 treatment treatment NN cord-005453-4057qib7 1262 15 for for IN cord-005453-4057qib7 1262 16 disease disease NN cord-005453-4057qib7 1262 17 relapse relapse NN cord-005453-4057qib7 1262 18 in in IN cord-005453-4057qib7 1262 19 patients patient NNS cord-005453-4057qib7 1262 20 who who WP cord-005453-4057qib7 1262 21 received receive VBD cord-005453-4057qib7 1262 22 peripheral peripheral JJ cord-005453-4057qib7 1262 23 blood blood NN cord-005453-4057qib7 1262 24 stem stem NN cord-005453-4057qib7 1262 25 cell cell NN cord-005453-4057qib7 1262 26 transplantation transplantation NN cord-005453-4057qib7 1262 27 ( ( -LRB- cord-005453-4057qib7 1262 28 alloPBSCT alloPBSCT NNP cord-005453-4057qib7 1262 29 ) ) -RRB- cord-005453-4057qib7 1262 30 from from IN cord-005453-4057qib7 1262 31 HLA HLA NNP cord-005453-4057qib7 1262 32 - - HYPH cord-005453-4057qib7 1262 33 matched match VBN cord-005453-4057qib7 1262 34 unrelated unrelated JJ cord-005453-4057qib7 1262 35 / / SYM cord-005453-4057qib7 1262 36 related relate VBN cord-005453-4057qib7 1262 37 plus plus CC cord-005453-4057qib7 1262 38 ptCy ptcy RB cord-005453-4057qib7 1262 39 as as IN cord-005453-4057qib7 1262 40 GVDH GVDH NNP cord-005453-4057qib7 1262 41 prophylaxis prophylaxis NN cord-005453-4057qib7 1262 42 in in IN cord-005453-4057qib7 1262 43 our -PRON- PRP$ cord-005453-4057qib7 1262 44 clinical clinical JJ cord-005453-4057qib7 1262 45 trial trial NN cord-005453-4057qib7 1262 46 ( ( -LRB- cord-005453-4057qib7 1262 47 NCT NCT NNP cord-005453-4057qib7 1262 48 02300571 02300571 CD cord-005453-4057qib7 1262 49 ) ) -RRB- cord-005453-4057qib7 1262 50 . . . cord-005453-4057qib7 1263 1 Methods method NNS cord-005453-4057qib7 1263 2 : : : cord-005453-4057qib7 1264 1 We -PRON- PRP cord-005453-4057qib7 1264 2 collected collect VBD cord-005453-4057qib7 1264 3 data datum NNS cord-005453-4057qib7 1264 4 from from IN cord-005453-4057qib7 1264 5 13 13 CD cord-005453-4057qib7 1264 6 patients patient NNS cord-005453-4057qib7 1264 7 , , , cord-005453-4057qib7 1264 8 treated treat VBN cord-005453-4057qib7 1264 9 with with IN cord-005453-4057qib7 1264 10 ptCy ptcy RB cord-005453-4057qib7 1265 1 ( ( -LRB- cord-005453-4057qib7 1265 2 50 50 CD cord-005453-4057qib7 1265 3 mg mg NNP cord-005453-4057qib7 1265 4 / / SYM cord-005453-4057qib7 1265 5 kg kg NNP cord-005453-4057qib7 1265 6 / / SYM cord-005453-4057qib7 1265 7 die die VBP cord-005453-4057qib7 1265 8 , , , cord-005453-4057qib7 1265 9 days day NNS cord-005453-4057qib7 1265 10 +3 +3 NNP cord-005453-4057qib7 1265 11 + + SYM cord-005453-4057qib7 1265 12 4 4 CD cord-005453-4057qib7 1265 13 ) ) -RRB- cord-005453-4057qib7 1265 14 , , , cord-005453-4057qib7 1265 15 mofetil mofetil NNP cord-005453-4057qib7 1265 16 mycophenolate mycophenolate NNP cord-005453-4057qib7 1265 17 ( ( -LRB- cord-005453-4057qib7 1265 18 MMF MMF NNP cord-005453-4057qib7 1265 19 ) ) -RRB- cord-005453-4057qib7 1265 20 and and CC cord-005453-4057qib7 1265 21 tacrolimus tacrolimus NNP cord-005453-4057qib7 1265 22 ( ( -LRB- cord-005453-4057qib7 1265 23 T T NNP cord-005453-4057qib7 1265 24 ) ) -RRB- cord-005453-4057qib7 1265 25 as as IN cord-005453-4057qib7 1265 26 GVHD GVHD NNP cord-005453-4057qib7 1265 27 prophylaxis prophylaxis NN cord-005453-4057qib7 1265 28 after after IN cord-005453-4057qib7 1265 29 allo allo NN cord-005453-4057qib7 1265 30 - - HYPH cord-005453-4057qib7 1265 31 PBSCT PBSCT NNP cord-005453-4057qib7 1265 32 , , , cord-005453-4057qib7 1265 33 who who WP cord-005453-4057qib7 1265 34 received receive VBD cord-005453-4057qib7 1265 35 DLI DLI NNP cord-005453-4057qib7 1265 36 infusions infusion NNS cord-005453-4057qib7 1265 37 . . . cord-005453-4057qib7 1266 1 They -PRON- PRP cord-005453-4057qib7 1266 2 were be VBD cord-005453-4057qib7 1266 3 treated treat VBN cord-005453-4057qib7 1266 4 between between IN cord-005453-4057qib7 1266 5 January January NNP cord-005453-4057qib7 1266 6 2013 2013 CD cord-005453-4057qib7 1266 7 and and CC cord-005453-4057qib7 1266 8 October October NNP cord-005453-4057qib7 1266 9 2018 2018 CD cord-005453-4057qib7 1266 10 . . . cord-005453-4057qib7 1267 1 We -PRON- PRP cord-005453-4057qib7 1267 2 report report VBP cord-005453-4057qib7 1267 3 data datum NNS cord-005453-4057qib7 1267 4 about about IN cord-005453-4057qib7 1267 5 overall overall JJ cord-005453-4057qib7 1267 6 response response NN cord-005453-4057qib7 1267 7 rate rate NN cord-005453-4057qib7 1267 8 ( ( -LRB- cord-005453-4057qib7 1267 9 ORR ORR NNP cord-005453-4057qib7 1267 10 ) ) -RRB- cord-005453-4057qib7 1267 11 , , , cord-005453-4057qib7 1267 12 disease disease NN cord-005453-4057qib7 1267 13 control control NN cord-005453-4057qib7 1267 14 rate rate NN cord-005453-4057qib7 1267 15 ( ( -LRB- cord-005453-4057qib7 1267 16 DCR DCR NNP cord-005453-4057qib7 1267 17 ) ) -RRB- cord-005453-4057qib7 1267 18 , , , cord-005453-4057qib7 1267 19 and and CC cord-005453-4057qib7 1267 20 DLI DLI NNP cord-005453-4057qib7 1267 21 - - HYPH cord-005453-4057qib7 1267 22 related relate VBN cord-005453-4057qib7 1267 23 mortality mortality NN cord-005453-4057qib7 1267 24 and and CC cord-005453-4057qib7 1267 25 morbidity morbidity NN cord-005453-4057qib7 1267 26 . . . cord-005453-4057qib7 1268 1 Diagnosis diagnosis NN cord-005453-4057qib7 1268 2 were be VBD cord-005453-4057qib7 1268 3 as as IN cord-005453-4057qib7 1268 4 follow follow NN cord-005453-4057qib7 1268 5 : : : cord-005453-4057qib7 1268 6 5 5 CD cord-005453-4057qib7 1268 7 had have VBD cord-005453-4057qib7 1268 8 multiple multiple JJ cord-005453-4057qib7 1268 9 myeloma myeloma NN cord-005453-4057qib7 1268 10 , , , cord-005453-4057qib7 1268 11 3 3 CD cord-005453-4057qib7 1268 12 had have VBD cord-005453-4057qib7 1268 13 acute acute JJ cord-005453-4057qib7 1268 14 myeloid myeloid JJ cord-005453-4057qib7 1268 15 leukemia leukemia NN cord-005453-4057qib7 1268 16 , , , cord-005453-4057qib7 1268 17 3 3 CD cord-005453-4057qib7 1268 18 had have VBD cord-005453-4057qib7 1268 19 acute acute JJ cord-005453-4057qib7 1268 20 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 1268 21 leukemia leukemia NN cord-005453-4057qib7 1268 22 and and CC cord-005453-4057qib7 1268 23 2 2 CD cord-005453-4057qib7 1268 24 had have VBD cord-005453-4057qib7 1268 25 lymphomas lymphoma NNS cord-005453-4057qib7 1268 26 . . . cord-005453-4057qib7 1269 1 All all DT cord-005453-4057qib7 1269 2 patients patient NNS cord-005453-4057qib7 1269 3 but but CC cord-005453-4057qib7 1269 4 one one CD cord-005453-4057qib7 1269 5 , , , cord-005453-4057qib7 1269 6 who who WP cord-005453-4057qib7 1269 7 had have VBD cord-005453-4057qib7 1269 8 chimerism chimerism NN cord-005453-4057qib7 1269 9 loss loss NN cord-005453-4057qib7 1269 10 , , , cord-005453-4057qib7 1269 11 received receive VBD cord-005453-4057qib7 1269 12 DLI DLI NNP cord-005453-4057qib7 1269 13 because because IN cord-005453-4057qib7 1269 14 of of IN cord-005453-4057qib7 1269 15 disease disease NN cord-005453-4057qib7 1269 16 relapse relapse NN cord-005453-4057qib7 1269 17 . . . cord-005453-4057qib7 1270 1 Results result NNS cord-005453-4057qib7 1270 2 : : : cord-005453-4057qib7 1271 1 Median median JJ cord-005453-4057qib7 1271 2 time time NN cord-005453-4057qib7 1271 3 between between IN cord-005453-4057qib7 1271 4 transplant transplant NN cord-005453-4057qib7 1271 5 and and CC cord-005453-4057qib7 1271 6 DLI DLI NNP cord-005453-4057qib7 1271 7 was be VBD cord-005453-4057qib7 1271 8 9 9 CD cord-005453-4057qib7 1272 1 ( ( -LRB- cord-005453-4057qib7 1272 2 range range NNP cord-005453-4057qib7 1272 3 3 3 CD cord-005453-4057qib7 1272 4 - - SYM cord-005453-4057qib7 1272 5 87 87 CD cord-005453-4057qib7 1272 6 ) ) -RRB- cord-005453-4057qib7 1272 7 months month NNS cord-005453-4057qib7 1272 8 . . . cord-005453-4057qib7 1273 1 Median median JJ cord-005453-4057qib7 1273 2 number number NN cord-005453-4057qib7 1273 3 of of IN cord-005453-4057qib7 1273 4 DLI DLI NNP cord-005453-4057qib7 1273 5 infusions infusion NNS cord-005453-4057qib7 1273 6 was be VBD cord-005453-4057qib7 1273 7 2 2 CD cord-005453-4057qib7 1274 1 ( ( -LRB- cord-005453-4057qib7 1274 2 range range NNP cord-005453-4057qib7 1274 3 1 1 CD cord-005453-4057qib7 1274 4 - - SYM cord-005453-4057qib7 1274 5 13 13 CD cord-005453-4057qib7 1274 6 ) ) -RRB- cord-005453-4057qib7 1274 7 . . . cord-005453-4057qib7 1275 1 10 10 CD cord-005453-4057qib7 1275 2 patients patient NNS cord-005453-4057qib7 1275 3 ( ( -LRB- cord-005453-4057qib7 1275 4 77 77 CD cord-005453-4057qib7 1275 5 % % NN cord-005453-4057qib7 1275 6 ) ) -RRB- cord-005453-4057qib7 1275 7 received receive VBD cord-005453-4057qib7 1275 8 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 1275 9 300 300 CD cord-005453-4057qib7 1275 10 mg mg NNP cord-005453-4057qib7 1275 11 / / SYM cord-005453-4057qib7 1275 12 m2 m2 NNP cord-005453-4057qib7 1275 13 preparative preparative JJ cord-005453-4057qib7 1275 14 regimen regimen NN cord-005453-4057qib7 1275 15 the the DT cord-005453-4057qib7 1275 16 day day NN cord-005453-4057qib7 1275 17 before before IN cord-005453-4057qib7 1275 18 the the DT cord-005453-4057qib7 1275 19 cryopreserved cryopreserved JJ cord-005453-4057qib7 1275 20 DLI DLI NNP cord-005453-4057qib7 1275 21 infusions infusion NNS cord-005453-4057qib7 1275 22 , , , cord-005453-4057qib7 1275 23 while while IN cord-005453-4057qib7 1275 24 in in IN cord-005453-4057qib7 1275 25 the the DT cord-005453-4057qib7 1275 26 other other JJ cord-005453-4057qib7 1275 27 3 3 CD cord-005453-4057qib7 1275 28 cases case NNS cord-005453-4057qib7 1275 29 DLI DLI NNP cord-005453-4057qib7 1275 30 were be VBD cord-005453-4057qib7 1275 31 associated associate VBN cord-005453-4057qib7 1275 32 with with IN cord-005453-4057qib7 1275 33 Lenalidomide Lenalidomide NNP cord-005453-4057qib7 1275 34 , , , cord-005453-4057qib7 1275 35 Ponatinib Ponatinib NNP cord-005453-4057qib7 1275 36 and and CC cord-005453-4057qib7 1275 37 5-Azacitidine 5-azacitidine CD cord-005453-4057qib7 1275 38 . . . cord-005453-4057qib7 1276 1 The the DT cord-005453-4057qib7 1276 2 overall overall JJ cord-005453-4057qib7 1276 3 response response NN cord-005453-4057qib7 1276 4 rate rate NN cord-005453-4057qib7 1276 5 ( ( -LRB- cord-005453-4057qib7 1276 6 ORR ORR NNP cord-005453-4057qib7 1276 7 ) ) -RRB- cord-005453-4057qib7 1276 8 was be VBD cord-005453-4057qib7 1276 9 50 50 CD cord-005453-4057qib7 1276 10 % % NN cord-005453-4057qib7 1276 11 , , , cord-005453-4057qib7 1276 12 while while IN cord-005453-4057qib7 1276 13 disease disease NN cord-005453-4057qib7 1276 14 control control NN cord-005453-4057qib7 1276 15 rate rate NN cord-005453-4057qib7 1276 16 ( ( -LRB- cord-005453-4057qib7 1276 17 DCR DCR NNP cord-005453-4057qib7 1276 18 ) ) -RRB- cord-005453-4057qib7 1276 19 was be VBD cord-005453-4057qib7 1276 20 achieved achieve VBN cord-005453-4057qib7 1276 21 in in IN cord-005453-4057qib7 1276 22 75 75 CD cord-005453-4057qib7 1276 23 % % NN cord-005453-4057qib7 1276 24 . . . cord-005453-4057qib7 1277 1 The the DT cord-005453-4057qib7 1277 2 patient patient NN cord-005453-4057qib7 1277 3 who who WP cord-005453-4057qib7 1277 4 received receive VBD cord-005453-4057qib7 1277 5 DLI DLI NNP cord-005453-4057qib7 1277 6 because because IN cord-005453-4057qib7 1277 7 of of IN cord-005453-4057qib7 1277 8 loss loss NN cord-005453-4057qib7 1277 9 of of IN cord-005453-4057qib7 1277 10 chimerism chimerism NN cord-005453-4057qib7 1277 11 converted convert VBD cord-005453-4057qib7 1277 12 it -PRON- PRP cord-005453-4057qib7 1277 13 in in IN cord-005453-4057qib7 1277 14 full full JJ cord-005453-4057qib7 1277 15 donor donor NN cord-005453-4057qib7 1277 16 after after IN cord-005453-4057qib7 1277 17 2 2 CD cord-005453-4057qib7 1277 18 infusions infusion NNS cord-005453-4057qib7 1277 19 . . . cord-005453-4057qib7 1278 1 After after IN cord-005453-4057qib7 1278 2 DLI DLI NNP cord-005453-4057qib7 1278 3 treatment treatment NN cord-005453-4057qib7 1278 4 the the DT cord-005453-4057qib7 1278 5 incidence incidence NN cord-005453-4057qib7 1278 6 of of IN cord-005453-4057qib7 1278 7 acute acute JJ cord-005453-4057qib7 1278 8 GVHD GVHD NNP cord-005453-4057qib7 1278 9 grade grade NN cord-005453-4057qib7 1278 10 I I NNP cord-005453-4057qib7 1278 11 - - HYPH cord-005453-4057qib7 1278 12 III III NNP cord-005453-4057qib7 1278 13 was be VBD cord-005453-4057qib7 1278 14 54 54 CD cord-005453-4057qib7 1278 15 % % NN cord-005453-4057qib7 1278 16 , , , cord-005453-4057qib7 1279 1 while while IN cord-005453-4057qib7 1279 2 was be VBD cord-005453-4057qib7 1279 3 46 46 CD cord-005453-4057qib7 1279 4 % % NN cord-005453-4057qib7 1279 5 for for IN cord-005453-4057qib7 1279 6 grade grade NN cord-005453-4057qib7 1279 7 II II NNP cord-005453-4057qib7 1279 8 - - HYPH cord-005453-4057qib7 1279 9 III III NNP cord-005453-4057qib7 1279 10 and and CC cord-005453-4057qib7 1279 11 patients patient NNS cord-005453-4057qib7 1279 12 were be VBD cord-005453-4057qib7 1279 13 started start VBN cord-005453-4057qib7 1279 14 on on IN cord-005453-4057qib7 1279 15 short short JJ cord-005453-4057qib7 1279 16 course course NN cord-005453-4057qib7 1279 17 of of IN cord-005453-4057qib7 1279 18 systemic systemic JJ cord-005453-4057qib7 1279 19 immunosuppression immunosuppression NN cord-005453-4057qib7 1279 20 treatments treatment NNS cord-005453-4057qib7 1279 21 . . . cord-005453-4057qib7 1280 1 None none NN cord-005453-4057qib7 1280 2 of of IN cord-005453-4057qib7 1280 3 these these DT cord-005453-4057qib7 1280 4 patients patient NNS cord-005453-4057qib7 1280 5 died die VBD cord-005453-4057qib7 1280 6 because because IN cord-005453-4057qib7 1280 7 of of IN cord-005453-4057qib7 1280 8 DLI DLI NNP cord-005453-4057qib7 1280 9 adverse adverse JJ cord-005453-4057qib7 1280 10 events event NNS cord-005453-4057qib7 1280 11 . . . cord-005453-4057qib7 1281 1 Estimated estimate VBN cord-005453-4057qib7 1281 2 1-year 1-year CD cord-005453-4057qib7 1281 3 overall overall JJ cord-005453-4057qib7 1281 4 survival survival NN cord-005453-4057qib7 1281 5 was be VBD cord-005453-4057qib7 1281 6 77 77 CD cord-005453-4057qib7 1281 7 % % NN cord-005453-4057qib7 1281 8 with with IN cord-005453-4057qib7 1281 9 a a DT cord-005453-4057qib7 1281 10 limited limited JJ cord-005453-4057qib7 1281 11 follow follow NN cord-005453-4057qib7 1281 12 - - HYPH cord-005453-4057qib7 1281 13 up up NN cord-005453-4057qib7 1281 14 length length NN cord-005453-4057qib7 1281 15 ( ( -LRB- cord-005453-4057qib7 1281 16 6 6 CD cord-005453-4057qib7 1281 17 months month NNS cord-005453-4057qib7 1281 18 ) ) -RRB- cord-005453-4057qib7 1281 19 . . . cord-005453-4057qib7 1282 1 Conclusions conclusion NNS cord-005453-4057qib7 1282 2 : : : cord-005453-4057qib7 1283 1 The the DT cord-005453-4057qib7 1283 2 infusion infusion NN cord-005453-4057qib7 1283 3 of of IN cord-005453-4057qib7 1283 4 non non JJ cord-005453-4057qib7 1283 5 - - JJ cord-005453-4057qib7 1283 6 manipulated manipulate VBN cord-005453-4057qib7 1283 7 lymphocytes lymphocyte NNS cord-005453-4057qib7 1283 8 from from IN cord-005453-4057qib7 1283 9 allogeneic allogeneic NN cord-005453-4057qib7 1283 10 donors donor NNS cord-005453-4057qib7 1283 11 is be VBZ cord-005453-4057qib7 1283 12 a a DT cord-005453-4057qib7 1283 13 valuable valuable JJ cord-005453-4057qib7 1283 14 and and CC cord-005453-4057qib7 1283 15 safe safe JJ cord-005453-4057qib7 1283 16 strategy strategy NN cord-005453-4057qib7 1283 17 of of IN cord-005453-4057qib7 1283 18 treatment treatment NN cord-005453-4057qib7 1283 19 for for IN cord-005453-4057qib7 1283 20 patients patient NNS cord-005453-4057qib7 1283 21 relapsing relapse VBG cord-005453-4057qib7 1283 22 after after IN cord-005453-4057qib7 1283 23 alloPBSCT alloPBSCT NNP cord-005453-4057qib7 1283 24 with with IN cord-005453-4057qib7 1283 25 ptCy ptcy RB cord-005453-4057qib7 1283 26 . . . cord-005453-4057qib7 1284 1 ptCy ptcy RB cord-005453-4057qib7 1284 2 showed show VBD cord-005453-4057qib7 1284 3 high high JJ cord-005453-4057qib7 1284 4 efficacy efficacy NN cord-005453-4057qib7 1284 5 in in IN cord-005453-4057qib7 1284 6 GVHD GVHD NNP cord-005453-4057qib7 1284 7 prevention prevention NN cord-005453-4057qib7 1284 8 , , , cord-005453-4057qib7 1284 9 allowing allow VBG cord-005453-4057qib7 1284 10 early early JJ cord-005453-4057qib7 1284 11 discontinuation discontinuation NN cord-005453-4057qib7 1284 12 of of IN cord-005453-4057qib7 1284 13 immunosuppression immunosuppression NN cord-005453-4057qib7 1284 14 drugs drug NNS cord-005453-4057qib7 1284 15 . . . cord-005453-4057qib7 1285 1 Because because IN cord-005453-4057qib7 1285 2 of of IN cord-005453-4057qib7 1285 3 this this DT cord-005453-4057qib7 1285 4 , , , cord-005453-4057qib7 1285 5 we -PRON- PRP cord-005453-4057qib7 1285 6 can can MD cord-005453-4057qib7 1285 7 reach reach VB cord-005453-4057qib7 1285 8 the the DT cord-005453-4057qib7 1285 9 goal goal NN cord-005453-4057qib7 1285 10 to to TO cord-005453-4057qib7 1285 11 transform transform VB cord-005453-4057qib7 1285 12 transplant transplant NN cord-005453-4057qib7 1285 13 in in IN cord-005453-4057qib7 1285 14 a a DT cord-005453-4057qib7 1285 15 platform platform NN cord-005453-4057qib7 1285 16 where where WRB cord-005453-4057qib7 1285 17 we -PRON- PRP cord-005453-4057qib7 1285 18 could could MD cord-005453-4057qib7 1285 19 add add VB cord-005453-4057qib7 1285 20 early early JJ cord-005453-4057qib7 1285 21 DLI DLI NNP cord-005453-4057qib7 1285 22 infusions infusion NNS cord-005453-4057qib7 1285 23 as as IN cord-005453-4057qib7 1285 24 a a DT cord-005453-4057qib7 1285 25 new new JJ cord-005453-4057qib7 1285 26 strategy strategy NN cord-005453-4057qib7 1285 27 for for IN cord-005453-4057qib7 1285 28 disease disease NNP cord-005453-4057qib7 1285 29 control control NN cord-005453-4057qib7 1285 30 . . . cord-005453-4057qib7 1286 1 Clinical clinical JJ cord-005453-4057qib7 1286 2 Trial Trial NNP cord-005453-4057qib7 1286 3 Registry Registry NNP cord-005453-4057qib7 1286 4 : : : cord-005453-4057qib7 1287 1 NCT NCT NNP cord-005453-4057qib7 1287 2 02300571 02300571 CD cord-005453-4057qib7 1287 3 Disclosure Disclosure NNP cord-005453-4057qib7 1287 4 : : : cord-005453-4057qib7 1287 5 Nothing nothing NN cord-005453-4057qib7 1287 6 to to TO cord-005453-4057qib7 1287 7 declare declare VB cord-005453-4057qib7 1287 8 P074 P074 VBN cord-005453-4057qib7 1287 9 Extracorporeal extracorporeal NN cord-005453-4057qib7 1287 10 photopheresis photopheresis NN cord-005453-4057qib7 1287 11 in in IN cord-005453-4057qib7 1287 12 the the DT cord-005453-4057qib7 1287 13 treatment treatment NN cord-005453-4057qib7 1287 14 of of IN cord-005453-4057qib7 1287 15 refractory refractory JJ cord-005453-4057qib7 1287 16 chronic chronic JJ cord-005453-4057qib7 1287 17 GVHD GVHD NNP cord-005453-4057qib7 1287 18 : : : cord-005453-4057qib7 1288 1 Analysis analysis NN cord-005453-4057qib7 1288 2 of of IN cord-005453-4057qib7 1288 3 mononuclear mononuclear JJ cord-005453-4057qib7 1288 4 cell cell NN cord-005453-4057qib7 1288 5 infusion infusion NN cord-005453-4057qib7 1288 6 Gillen Gillen NNP cord-005453-4057qib7 1288 7 Oarbeascoa Oarbeascoa NNP cord-005453-4057qib7 1288 8 1 1 CD cord-005453-4057qib7 1288 9 , , , cord-005453-4057qib7 1288 10 Maria Maria NNP cord-005453-4057qib7 1288 11 Luisa Luisa NNP cord-005453-4057qib7 1288 12 Lozano Lozano NNP cord-005453-4057qib7 1288 13 2,3,4 2,3,4 CD cord-005453-4057qib7 1288 14 , , , cord-005453-4057qib7 1289 1 Luisa Luisa NNP cord-005453-4057qib7 1289 2 Maria Maria NNP cord-005453-4057qib7 1289 3 Guerra Guerra NNP cord-005453-4057qib7 1289 4 5 5 CD cord-005453-4057qib7 1289 5 , , , cord-005453-4057qib7 1289 6 Cristina Cristina NNP cord-005453-4057qib7 1289 7 Amunarriz Amunarriz NNP cord-005453-4057qib7 1289 8 6 6 CD cord-005453-4057qib7 1289 9 , , , cord-005453-4057qib7 1289 10 Nuria Nuria NNP cord-005453-4057qib7 1289 11 Revilla Revilla NNP cord-005453-4057qib7 1289 12 2,3,4 2,3,4 CD cord-005453-4057qib7 1289 13 , , , cord-005453-4057qib7 1289 14 Pastora Pastora NNP cord-005453-4057qib7 1289 15 Iniesta Iniesta NNP cord-005453-4057qib7 1289 16 2,3,4 2,3,4 CD cord-005453-4057qib7 1289 17 , , , cord-005453-4057qib7 1289 18 Cynthia Cynthia NNP cord-005453-4057qib7 1289 19 Acosta Acosta NNP cord-005453-4057qib7 1289 20 Fleitas Fleitas NNP cord-005453-4057qib7 1289 21 5 5 CD cord-005453-4057qib7 1289 22 , , , cord-005453-4057qib7 1289 23 Jose Jose NNP cord-005453-4057qib7 1289 24 Luis Luis NNP cord-005453-4057qib7 1289 25 Arroyo Arroyo NNP cord-005453-4057qib7 1289 26 6 6 CD cord-005453-4057qib7 1289 27 , , , cord-005453-4057qib7 1289 28 Eva Eva NNP cord-005453-4057qib7 1289 29 Martinez Martinez NNP cord-005453-4057qib7 1290 1 Revuelta Revuelta NNP cord-005453-4057qib7 1290 2 7 7 CD cord-005453-4057qib7 1290 3 , , , cord-005453-4057qib7 1290 4 Andrea Andrea NNP cord-005453-4057qib7 1290 5 Galego Galego NNP cord-005453-4057qib7 1290 6 8 8 CD cord-005453-4057qib7 1290 7 , , , cord-005453-4057qib7 1290 8 Dolores Dolores NNP cord-005453-4057qib7 1290 9 Hernandez Hernandez NNP cord-005453-4057qib7 1290 10 - - HYPH cord-005453-4057qib7 1290 11 Maraver Maraver NNP cord-005453-4057qib7 1290 12 9 9 CD cord-005453-4057qib7 1290 13 , , , cord-005453-4057qib7 1290 14 Mi Mi NNP cord-005453-4057qib7 1290 15 Kwon Kwon NNP cord-005453-4057qib7 1290 16 1,10 1,10 CD cord-005453-4057qib7 1290 17 , , , cord-005453-4057qib7 1290 18 Aurora Aurora NNP cord-005453-4057qib7 1290 19 Viejo Viejo NNP cord-005453-4057qib7 1290 20 9 9 CD cord-005453-4057qib7 1290 21 , , , cord-005453-4057qib7 1290 22 Jose Jose NNP cord-005453-4057qib7 1290 23 Maria Maria NNP cord-005453-4057qib7 1290 24 Garcia Garcia NNP cord-005453-4057qib7 1290 25 Gala Gala NNP cord-005453-4057qib7 1290 26 7 7 CD cord-005453-4057qib7 1290 27 , , , cord-005453-4057qib7 1290 28 Concepcion Concepcion NNP cord-005453-4057qib7 1290 29 Andon Andon NNP cord-005453-4057qib7 1290 30 Saavedra Saavedra NNP cord-005453-4057qib7 1290 31 8 8 CD cord-005453-4057qib7 1290 32 , , , cord-005453-4057qib7 1290 33 Jose Jose NNP cord-005453-4057qib7 1290 34 Luis Luis NNP cord-005453-4057qib7 1290 35 Diez Diez NNP cord-005453-4057qib7 1290 36 - - HYPH cord-005453-4057qib7 1290 37 Martin Martin NNP cord-005453-4057qib7 1290 38 1 1 CD cord-005453-4057qib7 1290 39 , , , cord-005453-4057qib7 1290 40 10 10 CD cord-005453-4057qib7 1290 41 , , , cord-005453-4057qib7 1290 42 11 11 CD cord-005453-4057qib7 1290 43 Background background NN cord-005453-4057qib7 1290 44 : : : cord-005453-4057qib7 1291 1 Extracorporeal extracorporeal JJ cord-005453-4057qib7 1291 2 photopheresis photopheresis NN cord-005453-4057qib7 1291 3 ( ( -LRB- cord-005453-4057qib7 1291 4 ECP ECP NNP cord-005453-4057qib7 1291 5 ) ) -RRB- cord-005453-4057qib7 1291 6 is be VBZ cord-005453-4057qib7 1291 7 an an DT cord-005453-4057qib7 1291 8 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 1291 9 treatment treatment NN cord-005453-4057qib7 1291 10 that that WDT cord-005453-4057qib7 1291 11 has have VBZ cord-005453-4057qib7 1291 12 shown show VBN cord-005453-4057qib7 1291 13 efficacy efficacy NN cord-005453-4057qib7 1291 14 in in IN cord-005453-4057qib7 1291 15 steroid steroid JJ cord-005453-4057qib7 1291 16 refractory refractory JJ cord-005453-4057qib7 1291 17 chronic chronic NN cord-005453-4057qib7 1291 18 GvHD GvHD NNP cord-005453-4057qib7 1291 19 , , , cord-005453-4057qib7 1291 20 but but CC cord-005453-4057qib7 1291 21 the the DT cord-005453-4057qib7 1291 22 mechanism mechanism NN cord-005453-4057qib7 1291 23 of of IN cord-005453-4057qib7 1291 24 action action NN cord-005453-4057qib7 1291 25 is be VBZ cord-005453-4057qib7 1291 26 only only RB cord-005453-4057qib7 1291 27 partially partially RB cord-005453-4057qib7 1291 28 understood understand VBN cord-005453-4057qib7 1291 29 . . . cord-005453-4057qib7 1292 1 In in IN cord-005453-4057qib7 1292 2 some some DT cord-005453-4057qib7 1292 3 studies study NNS cord-005453-4057qib7 1292 4 , , , cord-005453-4057qib7 1292 5 a a DT cord-005453-4057qib7 1292 6 correlation correlation NN cord-005453-4057qib7 1292 7 has have VBZ cord-005453-4057qib7 1292 8 been be VBN cord-005453-4057qib7 1292 9 suggested suggest VBN cord-005453-4057qib7 1292 10 between between IN cord-005453-4057qib7 1292 11 treated treat VBN cord-005453-4057qib7 1292 12 Mononuclear Mononuclear NNP cord-005453-4057qib7 1292 13 cells cell NNS cord-005453-4057qib7 1292 14 ( ( -LRB- cord-005453-4057qib7 1292 15 MNC MNC NNP cord-005453-4057qib7 1292 16 ) ) -RRB- cord-005453-4057qib7 1292 17 or or CC cord-005453-4057qib7 1292 18 lymphocytes lymphocyte NNS cord-005453-4057qib7 1292 19 and and CC cord-005453-4057qib7 1292 20 response response NN cord-005453-4057qib7 1292 21 to to IN cord-005453-4057qib7 1292 22 ECP ECP NNP cord-005453-4057qib7 1292 23 . . . cord-005453-4057qib7 1293 1 The the DT cord-005453-4057qib7 1293 2 objective objective NN cord-005453-4057qib7 1293 3 of of IN cord-005453-4057qib7 1293 4 the the DT cord-005453-4057qib7 1293 5 study study NN cord-005453-4057qib7 1293 6 was be VBD cord-005453-4057qib7 1293 7 to to TO cord-005453-4057qib7 1293 8 analyze analyze VB cord-005453-4057qib7 1293 9 the the DT cord-005453-4057qib7 1293 10 relationship relationship NN cord-005453-4057qib7 1293 11 between between IN cord-005453-4057qib7 1293 12 the the DT cord-005453-4057qib7 1293 13 infused infuse VBN cord-005453-4057qib7 1293 14 cellularity cellularity NN cord-005453-4057qib7 1293 15 and and CC cord-005453-4057qib7 1293 16 response response NN cord-005453-4057qib7 1293 17 in in IN cord-005453-4057qib7 1293 18 chronic chronic JJ cord-005453-4057qib7 1293 19 GvHD GvHD NNP cord-005453-4057qib7 1293 20 . . . cord-005453-4057qib7 1294 1 Methods method NNS cord-005453-4057qib7 1294 2 : : : cord-005453-4057qib7 1294 3 48 48 CD cord-005453-4057qib7 1294 4 patients patient NNS cord-005453-4057qib7 1294 5 from from IN cord-005453-4057qib7 1294 6 7 7 CD cord-005453-4057qib7 1294 7 different different JJ cord-005453-4057qib7 1294 8 centers center NNS cord-005453-4057qib7 1294 9 with with IN cord-005453-4057qib7 1294 10 a a DT cord-005453-4057qib7 1294 11 total total NN cord-005453-4057qib7 1294 12 of of IN cord-005453-4057qib7 1294 13 930 930 CD cord-005453-4057qib7 1294 14 ECP ECP NNP cord-005453-4057qib7 1294 15 procedures procedure NNS cord-005453-4057qib7 1294 16 were be VBD cord-005453-4057qib7 1294 17 retrospectively retrospectively RB cord-005453-4057qib7 1294 18 analyzed analyze VBN cord-005453-4057qib7 1294 19 . . . cord-005453-4057qib7 1295 1 ECP ECP NNP cord-005453-4057qib7 1295 2 procedures procedure NNS cord-005453-4057qib7 1295 3 were be VBD cord-005453-4057qib7 1295 4 performed perform VBN cord-005453-4057qib7 1295 5 from from IN cord-005453-4057qib7 1295 6 January-2011 January-2011 NNP cord-005453-4057qib7 1295 7 to to IN cord-005453-4057qib7 1295 8 June-2017 june-2017 ADD cord-005453-4057qib7 1295 9 . . . cord-005453-4057qib7 1296 1 All all DT cord-005453-4057qib7 1296 2 ECP ECP NNP cord-005453-4057qib7 1296 3 procedures procedure NNS cord-005453-4057qib7 1296 4 were be VBD cord-005453-4057qib7 1296 5 performed perform VBN cord-005453-4057qib7 1296 6 with with IN cord-005453-4057qib7 1296 7 the the DT cord-005453-4057qib7 1296 8 off off JJ cord-005453-4057qib7 1296 9 - - HYPH cord-005453-4057qib7 1296 10 line line NN cord-005453-4057qib7 1296 11 system system NN cord-005453-4057qib7 1296 12 . . . cord-005453-4057qib7 1297 1 The the DT cord-005453-4057qib7 1297 2 response response NN cord-005453-4057qib7 1297 3 was be VBD cord-005453-4057qib7 1297 4 defined define VBN cord-005453-4057qib7 1297 5 as as IN cord-005453-4057qib7 1297 6 Responder Responder NNP cord-005453-4057qib7 1297 7 ( ( -LRB- cord-005453-4057qib7 1297 8 Complete complete JJ cord-005453-4057qib7 1297 9 and and CC cord-005453-4057qib7 1297 10 Partial Partial NNP cord-005453-4057qib7 1297 11 Response Response NNP cord-005453-4057qib7 1297 12 ) ) -RRB- cord-005453-4057qib7 1297 13 and and CC cord-005453-4057qib7 1297 14 Non Non NNP cord-005453-4057qib7 1297 15 - - NN cord-005453-4057qib7 1297 16 responder responder NN cord-005453-4057qib7 1297 17 . . . cord-005453-4057qib7 1298 1 Infused infuse VBN cord-005453-4057qib7 1298 2 cell cell NN cord-005453-4057qib7 1298 3 numbers number NNS cord-005453-4057qib7 1298 4 for for IN cord-005453-4057qib7 1298 5 lymphocytes lymphocyte NNS cord-005453-4057qib7 1298 6 , , , cord-005453-4057qib7 1298 7 monocytes monocyte NNS cord-005453-4057qib7 1298 8 and and CC cord-005453-4057qib7 1298 9 mononuclear mononuclear NN cord-005453-4057qib7 1298 10 cells cell NNS cord-005453-4057qib7 1298 11 ( ( -LRB- cord-005453-4057qib7 1298 12 Lym+Mon Lym+Mon NNP cord-005453-4057qib7 1298 13 , , , cord-005453-4057qib7 1298 14 MNC MNC NNP cord-005453-4057qib7 1298 15 ) ) -RRB- cord-005453-4057qib7 1298 16 were be VBD cord-005453-4057qib7 1298 17 calculated calculate VBN cord-005453-4057qib7 1298 18 . . . cord-005453-4057qib7 1299 1 For for IN cord-005453-4057qib7 1299 2 analytic analytic JJ cord-005453-4057qib7 1299 3 purposes purpose NNS cord-005453-4057qib7 1299 4 , , , cord-005453-4057qib7 1299 5 the the DT cord-005453-4057qib7 1299 6 median median JJ cord-005453-4057qib7 1299 7 number number NN cord-005453-4057qib7 1299 8 of of IN cord-005453-4057qib7 1299 9 cells cell NNS cord-005453-4057qib7 1299 10 infused infuse VBN cord-005453-4057qib7 1299 11 per per IN cord-005453-4057qib7 1299 12 procedure procedure NN cord-005453-4057qib7 1299 13 until until IN cord-005453-4057qib7 1299 14 response response NN cord-005453-4057qib7 1299 15 ( ( -LRB- cord-005453-4057qib7 1299 16 or or CC cord-005453-4057qib7 1299 17 until until IN cord-005453-4057qib7 1299 18 the the DT cord-005453-4057qib7 1299 19 median median JJ cord-005453-4057qib7 1299 20 number number NN cord-005453-4057qib7 1299 21 of of IN cord-005453-4057qib7 1299 22 procedures procedure NNS cord-005453-4057qib7 1299 23 until until IN cord-005453-4057qib7 1299 24 response response NN cord-005453-4057qib7 1299 25 for for IN cord-005453-4057qib7 1299 26 non non JJ cord-005453-4057qib7 1299 27 - - JJ cord-005453-4057qib7 1299 28 responding respond VBG cord-005453-4057qib7 1299 29 patients patient NNS cord-005453-4057qib7 1299 30 ) ) -RRB- cord-005453-4057qib7 1299 31 and and CC cord-005453-4057qib7 1299 32 the the DT cord-005453-4057qib7 1299 33 cumulative cumulative JJ cord-005453-4057qib7 1299 34 number number NN cord-005453-4057qib7 1299 35 of of IN cord-005453-4057qib7 1299 36 cells cell NNS cord-005453-4057qib7 1299 37 infused infuse VBN cord-005453-4057qib7 1299 38 until until IN cord-005453-4057qib7 1299 39 response response NN cord-005453-4057qib7 1299 40 ( ( -LRB- cord-005453-4057qib7 1299 41 or or CC cord-005453-4057qib7 1299 42 until until IN cord-005453-4057qib7 1299 43 the the DT cord-005453-4057qib7 1299 44 median median NN cord-005453-4057qib7 1299 45 in in IN cord-005453-4057qib7 1299 46 non non NNS cord-005453-4057qib7 1299 47 - - NNS cord-005453-4057qib7 1299 48 responders responder NNS cord-005453-4057qib7 1299 49 ) ) -RRB- cord-005453-4057qib7 1299 50 were be VBD cord-005453-4057qib7 1299 51 calculated calculate VBN cord-005453-4057qib7 1299 52 for for IN cord-005453-4057qib7 1299 53 all all PDT cord-005453-4057qib7 1299 54 the the DT cord-005453-4057qib7 1299 55 subgroups subgroup NNS cord-005453-4057qib7 1299 56 . . . cord-005453-4057qib7 1300 1 Same same JJ cord-005453-4057qib7 1300 2 procedures procedure NNS cord-005453-4057qib7 1300 3 were be VBD cord-005453-4057qib7 1300 4 performed perform VBN cord-005453-4057qib7 1300 5 with with IN cord-005453-4057qib7 1300 6 the the DT cord-005453-4057qib7 1300 7 number number NN cord-005453-4057qib7 1300 8 cells cell NNS cord-005453-4057qib7 1300 9 infused infuse VBN cord-005453-4057qib7 1300 10 until until IN cord-005453-4057qib7 1300 11 day day NN cord-005453-4057qib7 1300 12 30 30 CD cord-005453-4057qib7 1300 13 of of IN cord-005453-4057qib7 1300 14 ECP ECP NNP cord-005453-4057qib7 1300 15 . . . cord-005453-4057qib7 1301 1 Finally finally RB cord-005453-4057qib7 1301 2 , , , cord-005453-4057qib7 1301 3 the the DT cord-005453-4057qib7 1301 4 response response NN cord-005453-4057qib7 1301 5 and and CC cord-005453-4057qib7 1301 6 survival survival NN cord-005453-4057qib7 1301 7 impact impact NN cord-005453-4057qib7 1301 8 of of IN cord-005453-4057qib7 1301 9 infusing infuse VBG cord-005453-4057qib7 1301 10 a a DT cord-005453-4057qib7 1301 11 number number NN cord-005453-4057qib7 1301 12 of of IN cord-005453-4057qib7 1301 13 cells cell NNS cord-005453-4057qib7 1301 14 over over IN cord-005453-4057qib7 1301 15 or or CC cord-005453-4057qib7 1301 16 below below IN cord-005453-4057qib7 1301 17 the the DT cord-005453-4057qib7 1301 18 median median NN cord-005453-4057qib7 1301 19 and and CC cord-005453-4057qib7 1301 20 in in IN cord-005453-4057qib7 1301 21 different different JJ cord-005453-4057qib7 1301 22 tertiles tertile NNS cord-005453-4057qib7 1301 23 ( ( -LRB- cord-005453-4057qib7 1301 24 T1 T1 NNP cord-005453-4057qib7 1301 25 , , , cord-005453-4057qib7 1301 26 T2 T2 NNP cord-005453-4057qib7 1301 27 and and CC cord-005453-4057qib7 1301 28 T3 T3 NNP cord-005453-4057qib7 1301 29 ) ) -RRB- cord-005453-4057qib7 1301 30 was be VBD cord-005453-4057qib7 1301 31 assessed assess VBN cord-005453-4057qib7 1301 32 until until IN cord-005453-4057qib7 1301 33 the the DT cord-005453-4057qib7 1301 34 median median JJ cord-005453-4057qib7 1301 35 number number NN cord-005453-4057qib7 1301 36 of of IN cord-005453-4057qib7 1301 37 procedures procedure NNS cord-005453-4057qib7 1301 38 needed need VBN cord-005453-4057qib7 1301 39 to to TO cord-005453-4057qib7 1301 40 achieve achieve VB cord-005453-4057qib7 1301 41 a a DT cord-005453-4057qib7 1301 42 response response NN cord-005453-4057qib7 1301 43 . . . cord-005453-4057qib7 1302 1 Results result NNS cord-005453-4057qib7 1302 2 : : : cord-005453-4057qib7 1303 1 The the DT cord-005453-4057qib7 1303 2 median median JJ cord-005453-4057qib7 1303 3 number number NN cord-005453-4057qib7 1303 4 of of IN cord-005453-4057qib7 1303 5 procedures procedure NNS cord-005453-4057qib7 1303 6 until until IN cord-005453-4057qib7 1303 7 response response NN cord-005453-4057qib7 1303 8 was be VBD cord-005453-4057qib7 1303 9 3 3 CD cord-005453-4057qib7 1303 10 . . . cord-005453-4057qib7 1304 1 We -PRON- PRP cord-005453-4057qib7 1304 2 observed observe VBD cord-005453-4057qib7 1304 3 no no DT cord-005453-4057qib7 1304 4 differences difference NNS cord-005453-4057qib7 1304 5 in in IN cord-005453-4057qib7 1304 6 the the DT cord-005453-4057qib7 1304 7 median median JJ cord-005453-4057qib7 1304 8 number number NN cord-005453-4057qib7 1304 9 of of IN cord-005453-4057qib7 1304 10 lymphocytes lymphocyte NNS cord-005453-4057qib7 1304 11 , , , cord-005453-4057qib7 1304 12 monocytes monocyte NNS cord-005453-4057qib7 1304 13 or or CC cord-005453-4057qib7 1304 14 MNCs mnc NNS cord-005453-4057qib7 1304 15 infused infuse VBN cord-005453-4057qib7 1304 16 until until IN cord-005453-4057qib7 1304 17 response response NN cord-005453-4057qib7 1304 18 or or CC cord-005453-4057qib7 1304 19 until until IN cord-005453-4057qib7 1304 20 day day NN cord-005453-4057qib7 1304 21 30 30 CD cord-005453-4057qib7 1304 22 between between IN cord-005453-4057qib7 1304 23 responding respond VBG cord-005453-4057qib7 1304 24 and and CC cord-005453-4057qib7 1304 25 non non JJ cord-005453-4057qib7 1304 26 - - JJ cord-005453-4057qib7 1304 27 responding respond VBG cord-005453-4057qib7 1304 28 patients patient NNS cord-005453-4057qib7 1304 29 . . . cord-005453-4057qib7 1305 1 There there EX cord-005453-4057qib7 1305 2 were be VBD cord-005453-4057qib7 1305 3 no no DT cord-005453-4057qib7 1305 4 differences difference NNS cord-005453-4057qib7 1305 5 in in IN cord-005453-4057qib7 1305 6 response response NN cord-005453-4057qib7 1305 7 if if IN cord-005453-4057qib7 1305 8 patients patient NNS cord-005453-4057qib7 1305 9 received receive VBD cord-005453-4057qib7 1305 10 lymphocytes lymphocyte NNS cord-005453-4057qib7 1305 11 or or CC cord-005453-4057qib7 1305 12 monocytes monocyte NNS cord-005453-4057qib7 1305 13 above above IN cord-005453-4057qib7 1305 14 or or CC cord-005453-4057qib7 1305 15 below below IN cord-005453-4057qib7 1305 16 the the DT cord-005453-4057qib7 1305 17 median median JJ cord-005453-4057qib7 1305 18 number number NN cord-005453-4057qib7 1305 19 . . . cord-005453-4057qib7 1306 1 Nevertheless nevertheless RB cord-005453-4057qib7 1306 2 , , , cord-005453-4057qib7 1306 3 patients patient NNS cord-005453-4057qib7 1306 4 that that WDT cord-005453-4057qib7 1306 5 received receive VBD cord-005453-4057qib7 1306 6 a a DT cord-005453-4057qib7 1306 7 total total JJ cord-005453-4057qib7 1306 8 absolute absolute JJ cord-005453-4057qib7 1306 9 number number NN cord-005453-4057qib7 1306 10 of of IN cord-005453-4057qib7 1306 11 MNCs mnc NNS cord-005453-4057qib7 1306 12 above above IN cord-005453-4057qib7 1306 13 the the DT cord-005453-4057qib7 1306 14 median median NN cord-005453-4057qib7 1306 15 ( ( -LRB- cord-005453-4057qib7 1306 16 64x108 64x108 NN cord-005453-4057qib7 1306 17 cells cell NNS cord-005453-4057qib7 1306 18 ) ) -RRB- cord-005453-4057qib7 1306 19 showed show VBD cord-005453-4057qib7 1306 20 a a DT cord-005453-4057qib7 1306 21 trend trend NN cord-005453-4057qib7 1306 22 towards towards IN cord-005453-4057qib7 1306 23 a a DT cord-005453-4057qib7 1306 24 higher high JJR cord-005453-4057qib7 1306 25 response response NN cord-005453-4057qib7 1306 26 rate rate NN cord-005453-4057qib7 1306 27 ( ( -LRB- cord-005453-4057qib7 1306 28 75 75 CD cord-005453-4057qib7 1306 29 % % NN cord-005453-4057qib7 1306 30 vs vs IN cord-005453-4057qib7 1306 31 61 61 CD cord-005453-4057qib7 1306 32 % % NN cord-005453-4057qib7 1306 33 , , , cord-005453-4057qib7 1306 34 p=0.09 p=0.09 NNP cord-005453-4057qib7 1306 35 ) ) -RRB- cord-005453-4057qib7 1306 36 . . . cord-005453-4057qib7 1307 1 The the DT cord-005453-4057qib7 1307 2 patients patient NNS cord-005453-4057qib7 1307 3 that that WDT cord-005453-4057qib7 1307 4 received receive VBD cord-005453-4057qib7 1307 5 a a DT cord-005453-4057qib7 1307 6 cumulative cumulative JJ cord-005453-4057qib7 1307 7 number number NN cord-005453-4057qib7 1307 8 of of IN cord-005453-4057qib7 1307 9 lymphocytes lymphocyte NNS cord-005453-4057qib7 1307 10 in in IN cord-005453-4057qib7 1307 11 the the DT cord-005453-4057qib7 1307 12 3 3 CD cord-005453-4057qib7 1307 13 first first JJ cord-005453-4057qib7 1307 14 ECP ECP NNP cord-005453-4057qib7 1307 15 procedures procedure NNS cord-005453-4057qib7 1307 16 above above IN cord-005453-4057qib7 1307 17 the the DT cord-005453-4057qib7 1307 18 median median NN cord-005453-4057qib7 1307 19 showed show VBD cord-005453-4057qib7 1307 20 improved improved JJ cord-005453-4057qib7 1307 21 overall overall JJ cord-005453-4057qib7 1307 22 survival survival NN cord-005453-4057qib7 1307 23 ( ( -LRB- cord-005453-4057qib7 1307 24 OS OS NNP cord-005453-4057qib7 1307 25 ) ) -RRB- cord-005453-4057qib7 1307 26 ( ( -LRB- cord-005453-4057qib7 1307 27 2y 2y NNP cord-005453-4057qib7 1307 28 OS OS NNP cord-005453-4057qib7 1307 29 85 85 CD cord-005453-4057qib7 1307 30 % % NN cord-005453-4057qib7 1307 31 vs vs IN cord-005453-4057qib7 1307 32 55 55 CD cord-005453-4057qib7 1307 33 % % NN cord-005453-4057qib7 1307 34 , , , cord-005453-4057qib7 1307 35 p=0.024 p=0.024 NNP cord-005453-4057qib7 1307 36 ) ) -RRB- cord-005453-4057qib7 1307 37 . . . cord-005453-4057qib7 1308 1 Patients patient NNS cord-005453-4057qib7 1308 2 that that WDT cord-005453-4057qib7 1308 3 received receive VBD cord-005453-4057qib7 1308 4 a a DT cord-005453-4057qib7 1308 5 number number NN cord-005453-4057qib7 1308 6 of of IN cord-005453-4057qib7 1308 7 monocytes monocyte NNS cord-005453-4057qib7 1308 8 above above IN cord-005453-4057qib7 1308 9 the the DT cord-005453-4057qib7 1308 10 median median NN cord-005453-4057qib7 1308 11 showed show VBD cord-005453-4057qib7 1308 12 a a DT cord-005453-4057qib7 1308 13 trend trend NN cord-005453-4057qib7 1308 14 towards towards IN cord-005453-4057qib7 1308 15 better well JJR cord-005453-4057qib7 1308 16 survival survival NN cord-005453-4057qib7 1308 17 ( ( -LRB- cord-005453-4057qib7 1308 18 p=0.09 p=0.09 NNP cord-005453-4057qib7 1308 19 ) ) -RRB- cord-005453-4057qib7 1308 20 , , , cord-005453-4057qib7 1308 21 that that WDT cord-005453-4057qib7 1308 22 was be VBD cord-005453-4057qib7 1308 23 significant significant JJ cord-005453-4057qib7 1308 24 when when WRB cord-005453-4057qib7 1308 25 the the DT cord-005453-4057qib7 1308 26 number number NN cord-005453-4057qib7 1308 27 of of IN cord-005453-4057qib7 1308 28 monocytes monocyte NNS cord-005453-4057qib7 1308 29 infused infuse VBN cord-005453-4057qib7 1308 30 surpassed surpass VBD cord-005453-4057qib7 1308 31 the the DT cord-005453-4057qib7 1308 32 first first JJ cord-005453-4057qib7 1308 33 tertile tertile NNP cord-005453-4057qib7 1308 34 ( ( -LRB- cord-005453-4057qib7 1308 35 2y 2y NNP cord-005453-4057qib7 1308 36 OS OS NNP cord-005453-4057qib7 1308 37 38 38 CD cord-005453-4057qib7 1308 38 % % NN cord-005453-4057qib7 1308 39 for for IN cord-005453-4057qib7 1308 40 T1 T1 NNP cord-005453-4057qib7 1308 41 , , , cord-005453-4057qib7 1308 42 79 79 CD cord-005453-4057qib7 1308 43 % % NN cord-005453-4057qib7 1308 44 for for IN cord-005453-4057qib7 1308 45 T2 T2 NNP cord-005453-4057qib7 1308 46 , , , cord-005453-4057qib7 1308 47 92 92 CD cord-005453-4057qib7 1308 48 % % NN cord-005453-4057qib7 1308 49 for for IN cord-005453-4057qib7 1308 50 T3 T3 NNP cord-005453-4057qib7 1308 51 , , , cord-005453-4057qib7 1308 52 p=0.003 p=0.003 NNP cord-005453-4057qib7 1308 53 ) ) -RRB- cord-005453-4057qib7 1308 54 . . . cord-005453-4057qib7 1309 1 Finally finally RB cord-005453-4057qib7 1309 2 , , , cord-005453-4057qib7 1309 3 the the DT cord-005453-4057qib7 1309 4 patients patient NNS cord-005453-4057qib7 1309 5 that that WDT cord-005453-4057qib7 1309 6 received receive VBD cord-005453-4057qib7 1309 7 a a DT cord-005453-4057qib7 1309 8 cumulative cumulative JJ cord-005453-4057qib7 1309 9 number number NN cord-005453-4057qib7 1309 10 of of IN cord-005453-4057qib7 1309 11 MNCs mnc NNS cord-005453-4057qib7 1309 12 above above IN cord-005453-4057qib7 1309 13 the the DT cord-005453-4057qib7 1309 14 first first JJ cord-005453-4057qib7 1309 15 tertile tertile NNP cord-005453-4057qib7 1309 16 also also RB cord-005453-4057qib7 1309 17 showed show VBD cord-005453-4057qib7 1309 18 improved improved JJ cord-005453-4057qib7 1309 19 survival survival NN cord-005453-4057qib7 1309 20 ( ( -LRB- cord-005453-4057qib7 1309 21 2y 2y NNP cord-005453-4057qib7 1309 22 OS OS NNP cord-005453-4057qib7 1309 23 47 47 CD cord-005453-4057qib7 1309 24 % % NN cord-005453-4057qib7 1309 25 for for IN cord-005453-4057qib7 1309 26 T1 T1 NNP cord-005453-4057qib7 1309 27 , , , cord-005453-4057qib7 1309 28 74 74 CD cord-005453-4057qib7 1309 29 % % NN cord-005453-4057qib7 1309 30 for for IN cord-005453-4057qib7 1309 31 T2 T2 NNP cord-005453-4057qib7 1309 32 , , , cord-005453-4057qib7 1309 33 94 94 CD cord-005453-4057qib7 1309 34 % % NN cord-005453-4057qib7 1309 35 for for IN cord-005453-4057qib7 1309 36 T3 T3 NNP cord-005453-4057qib7 1309 37 , , , cord-005453-4057qib7 1309 38 p=0.015 p=0.015 NNP cord-005453-4057qib7 1309 39 ) ) -RRB- cord-005453-4057qib7 1309 40 . . . cord-005453-4057qib7 1310 1 Conclusions conclusion NNS cord-005453-4057qib7 1310 2 : : : cord-005453-4057qib7 1311 1 There there EX cord-005453-4057qib7 1311 2 were be VBD cord-005453-4057qib7 1311 3 no no DT cord-005453-4057qib7 1311 4 differences difference NNS cord-005453-4057qib7 1311 5 in in IN cord-005453-4057qib7 1311 6 the the DT cord-005453-4057qib7 1311 7 infused infuse VBN cord-005453-4057qib7 1311 8 cellularity cellularity NN cord-005453-4057qib7 1311 9 between between IN cord-005453-4057qib7 1311 10 responding respond VBG cord-005453-4057qib7 1311 11 and and CC cord-005453-4057qib7 1311 12 non non JJ cord-005453-4057qib7 1311 13 - - JJ cord-005453-4057qib7 1311 14 responding respond VBG cord-005453-4057qib7 1311 15 patients patient NNS cord-005453-4057qib7 1311 16 with with IN cord-005453-4057qib7 1311 17 chronic chronic JJ cord-005453-4057qib7 1311 18 GvHD GvHD NNP cord-005453-4057qib7 1311 19 . . . cord-005453-4057qib7 1312 1 At at IN cord-005453-4057qib7 1312 2 the the DT cord-005453-4057qib7 1312 3 same same JJ cord-005453-4057qib7 1312 4 time time NN cord-005453-4057qib7 1312 5 , , , cord-005453-4057qib7 1312 6 we -PRON- PRP cord-005453-4057qib7 1312 7 found find VBD cord-005453-4057qib7 1312 8 that that IN cord-005453-4057qib7 1312 9 except except IN cord-005453-4057qib7 1312 10 for for IN cord-005453-4057qib7 1312 11 a a DT cord-005453-4057qib7 1312 12 trend trend NN cord-005453-4057qib7 1312 13 toward toward IN cord-005453-4057qib7 1312 14 better well JJR cord-005453-4057qib7 1312 15 response response NN cord-005453-4057qib7 1312 16 with with IN cord-005453-4057qib7 1312 17 higher high JJR cord-005453-4057qib7 1312 18 MNCs mnc NNS cord-005453-4057qib7 1312 19 infused infuse VBN cord-005453-4057qib7 1312 20 , , , cord-005453-4057qib7 1312 21 there there EX cord-005453-4057qib7 1312 22 was be VBD cord-005453-4057qib7 1312 23 no no DT cord-005453-4057qib7 1312 24 relationship relationship NN cord-005453-4057qib7 1312 25 between between IN cord-005453-4057qib7 1312 26 lymphocytes lymphocyte NNS cord-005453-4057qib7 1312 27 and and CC cord-005453-4057qib7 1312 28 monocytes monocyte NNS cord-005453-4057qib7 1312 29 with with IN cord-005453-4057qib7 1312 30 the the DT cord-005453-4057qib7 1312 31 response response NN cord-005453-4057qib7 1312 32 rate rate NN cord-005453-4057qib7 1312 33 as as IN cord-005453-4057qib7 1312 34 other other JJ cord-005453-4057qib7 1312 35 previous previous JJ cord-005453-4057qib7 1312 36 studies study NNS cord-005453-4057qib7 1312 37 have have VBP cord-005453-4057qib7 1312 38 suggested suggest VBN cord-005453-4057qib7 1312 39 . . . cord-005453-4057qib7 1313 1 However however RB cord-005453-4057qib7 1313 2 , , , cord-005453-4057qib7 1313 3 even even RB cord-005453-4057qib7 1313 4 if if IN cord-005453-4057qib7 1313 5 there there EX cord-005453-4057qib7 1313 6 is be VBZ cord-005453-4057qib7 1313 7 no no DT cord-005453-4057qib7 1313 8 relationship relationship NN cord-005453-4057qib7 1313 9 with with IN cord-005453-4057qib7 1313 10 the the DT cord-005453-4057qib7 1313 11 response response NN cord-005453-4057qib7 1313 12 rate rate NN cord-005453-4057qib7 1313 13 , , , cord-005453-4057qib7 1313 14 the the DT cord-005453-4057qib7 1313 15 patients patient NNS cord-005453-4057qib7 1313 16 receiving receive VBG cord-005453-4057qib7 1313 17 the the DT cord-005453-4057qib7 1313 18 highest high JJS cord-005453-4057qib7 1313 19 numbers number NNS cord-005453-4057qib7 1313 20 of of IN cord-005453-4057qib7 1313 21 lymphocytes lymphocyte NNS cord-005453-4057qib7 1313 22 , , , cord-005453-4057qib7 1313 23 monocytes monocyte NNS cord-005453-4057qib7 1313 24 and and CC cord-005453-4057qib7 1313 25 MNCs mnc NNS cord-005453-4057qib7 1313 26 in in IN cord-005453-4057qib7 1313 27 the the DT cord-005453-4057qib7 1313 28 cohort cohort NN cord-005453-4057qib7 1313 29 showed show VBD cord-005453-4057qib7 1313 30 an an DT cord-005453-4057qib7 1313 31 improved improved JJ cord-005453-4057qib7 1313 32 survival survival NN cord-005453-4057qib7 1313 33 , , , cord-005453-4057qib7 1313 34 suggesting suggest VBG cord-005453-4057qib7 1313 35 that that IN cord-005453-4057qib7 1313 36 larger large JJR cord-005453-4057qib7 1313 37 quantities quantity NNS cord-005453-4057qib7 1313 38 of of IN cord-005453-4057qib7 1313 39 cells cell NNS cord-005453-4057qib7 1313 40 could could MD cord-005453-4057qib7 1313 41 exhibit exhibit VB cord-005453-4057qib7 1313 42 a a DT cord-005453-4057qib7 1313 43 protective protective JJ cord-005453-4057qib7 1313 44 effect effect NN cord-005453-4057qib7 1313 45 . . . cord-005453-4057qib7 1314 1 Nevertheless nevertheless RB cord-005453-4057qib7 1314 2 , , , cord-005453-4057qib7 1314 3 prospective prospective JJ cord-005453-4057qib7 1314 4 studies study NNS cord-005453-4057qib7 1314 5 that that WDT cord-005453-4057qib7 1314 6 address address VBP cord-005453-4057qib7 1314 7 this this DT cord-005453-4057qib7 1314 8 relationship relationship NN cord-005453-4057qib7 1314 9 are be VBP cord-005453-4057qib7 1314 10 needed need VBN cord-005453-4057qib7 1314 11 . . . cord-005453-4057qib7 1315 1 Disclosure disclosure NN cord-005453-4057qib7 1315 2 : : : cord-005453-4057qib7 1315 3 Nothing nothing NN cord-005453-4057qib7 1315 4 to to TO cord-005453-4057qib7 1315 5 declare declare VB cord-005453-4057qib7 1315 6 Comparative comparative JJ cord-005453-4057qib7 1315 7 analysis analysis NN cord-005453-4057qib7 1315 8 of of IN cord-005453-4057qib7 1315 9 the the DT cord-005453-4057qib7 1315 10 cytotoxic cytotoxic JJ cord-005453-4057qib7 1315 11 potential potential NN cord-005453-4057qib7 1315 12 of of IN cord-005453-4057qib7 1315 13 cytokine cytokine NN cord-005453-4057qib7 1315 14 - - HYPH cord-005453-4057qib7 1315 15 induced induce VBN cord-005453-4057qib7 1315 16 killer killer NN cord-005453-4057qib7 1315 17 and and CC cord-005453-4057qib7 1315 18 natural natural JJ cord-005453-4057qib7 1315 19 killer killer NN cord-005453-4057qib7 1315 20 cells cell NNS cord-005453-4057qib7 1315 21 for for IN cord-005453-4057qib7 1315 22 neuroblastoma neuroblastoma NN cord-005453-4057qib7 1315 23 therapy therapy NN cord-005453-4057qib7 1315 24 Annekathrin Annekathrin NNP cord-005453-4057qib7 1315 25 Heinze Heinze NNP cord-005453-4057qib7 1315 26 1 1 CD cord-005453-4057qib7 1315 27 , , , cord-005453-4057qib7 1315 28 Beatrice Beatrice NNP cord-005453-4057qib7 1315 29 Grebe Grebe NNP cord-005453-4057qib7 1315 30 1 1 CD cord-005453-4057qib7 1315 31 , , , cord-005453-4057qib7 1315 32 Eva Eva NNP cord-005453-4057qib7 1315 33 Mudry Mudry NNP cord-005453-4057qib7 1315 34 1 1 CD cord-005453-4057qib7 1315 35 , , , cord-005453-4057qib7 1315 36 Jochen Jochen NNP cord-005453-4057qib7 1315 37 Früh Früh NNP cord-005453-4057qib7 1315 38 1 1 CD cord-005453-4057qib7 1315 39 , , , cord-005453-4057qib7 1315 40 Bushra Bushra NNP cord-005453-4057qib7 1315 41 Rais Rais NNP cord-005453-4057qib7 1315 42 1 1 CD cord-005453-4057qib7 1315 43 , , , cord-005453-4057qib7 1315 44 Claudia Claudia NNP cord-005453-4057qib7 1315 45 Cappel Cappel NNP cord-005453-4057qib7 1315 46 1 1 CD cord-005453-4057qib7 1315 47 , , , cord-005453-4057qib7 1315 48 Sabine Sabine NNP cord-005453-4057qib7 1315 49 Hünecke Hünecke NNP cord-005453-4057qib7 1315 50 1 1 CD cord-005453-4057qib7 1315 51 , , , cord-005453-4057qib7 1315 52 Eva Eva NNP cord-005453-4057qib7 1315 53 Rettinger Rettinger NNP cord-005453-4057qib7 1315 54 1 1 CD cord-005453-4057qib7 1315 55 , , , cord-005453-4057qib7 1315 56 Thomas Thomas NNP cord-005453-4057qib7 1315 57 Klingebiel Klingebiel NNP cord-005453-4057qib7 1315 58 1 1 CD cord-005453-4057qib7 1315 59 , , , cord-005453-4057qib7 1315 60 Peter Peter NNP cord-005453-4057qib7 1315 61 Bader Bader NNP cord-005453-4057qib7 1315 62 1 1 CD cord-005453-4057qib7 1315 63 , , , cord-005453-4057qib7 1315 64 Evelyn Evelyn NNP cord-005453-4057qib7 1315 65 Ullrich Ullrich NNP cord-005453-4057qib7 1316 1 1,2 1,2 CD cord-005453-4057qib7 1316 2 1 1 CD cord-005453-4057qib7 1316 3 University University NNP cord-005453-4057qib7 1316 4 Hospital Hospital NNP cord-005453-4057qib7 1316 5 Frankfurt Frankfurt NNP cord-005453-4057qib7 1316 6 , , , cord-005453-4057qib7 1316 7 Frankfurt Frankfurt NNP cord-005453-4057qib7 1316 8 , , , cord-005453-4057qib7 1316 9 Germany Germany NNP cord-005453-4057qib7 1316 10 , , , cord-005453-4057qib7 1316 11 2 2 CD cord-005453-4057qib7 1316 12 German German NNP cord-005453-4057qib7 1316 13 Cancer Cancer NNP cord-005453-4057qib7 1316 14 Consortium Consortium NNP cord-005453-4057qib7 1316 15 ( ( -LRB- cord-005453-4057qib7 1316 16 DKTK DKTK NNP cord-005453-4057qib7 1316 17 ) ) -RRB- cord-005453-4057qib7 1316 18 partner partner NN cord-005453-4057qib7 1316 19 site site NN cord-005453-4057qib7 1316 20 : : : cord-005453-4057qib7 1316 21 , , , cord-005453-4057qib7 1316 22 Frankfurt Frankfurt NNP cord-005453-4057qib7 1316 23 , , , cord-005453-4057qib7 1316 24 Germany Germany NNP cord-005453-4057qib7 1316 25 Background Background NNP cord-005453-4057qib7 1316 26 : : : cord-005453-4057qib7 1316 27 Neuroblastoma Neuroblastoma NNP cord-005453-4057qib7 1316 28 ( ( -LRB- cord-005453-4057qib7 1316 29 NB NB NNP cord-005453-4057qib7 1316 30 ) ) -RRB- cord-005453-4057qib7 1316 31 is be VBZ cord-005453-4057qib7 1316 32 the the DT cord-005453-4057qib7 1316 33 most most RBS cord-005453-4057qib7 1316 34 common common JJ cord-005453-4057qib7 1316 35 solid solid JJ cord-005453-4057qib7 1316 36 extracranial extracranial JJ cord-005453-4057qib7 1316 37 tumor tumor NN cord-005453-4057qib7 1316 38 in in IN cord-005453-4057qib7 1316 39 childhood childhood NN cord-005453-4057qib7 1316 40 . . . cord-005453-4057qib7 1317 1 Despite despite IN cord-005453-4057qib7 1317 2 therapeutic therapeutic JJ cord-005453-4057qib7 1317 3 progress progress NN cord-005453-4057qib7 1317 4 , , , cord-005453-4057qib7 1317 5 prognosis prognosis NN cord-005453-4057qib7 1317 6 for for IN cord-005453-4057qib7 1317 7 high high JJ cord-005453-4057qib7 1317 8 - - HYPH cord-005453-4057qib7 1317 9 risk risk NN cord-005453-4057qib7 1317 10 NB NB NNP cord-005453-4057qib7 1317 11 is be VBZ cord-005453-4057qib7 1317 12 poor poor JJ cord-005453-4057qib7 1317 13 and and CC cord-005453-4057qib7 1317 14 innovative innovative JJ cord-005453-4057qib7 1317 15 therapies therapy NNS cord-005453-4057qib7 1317 16 are be VBP cord-005453-4057qib7 1317 17 of of IN cord-005453-4057qib7 1317 18 medical medical JJ cord-005453-4057qib7 1317 19 need need NN cord-005453-4057qib7 1317 20 . . . cord-005453-4057qib7 1318 1 Therefore therefore RB cord-005453-4057qib7 1318 2 , , , cord-005453-4057qib7 1318 3 we -PRON- PRP cord-005453-4057qib7 1318 4 investigated investigate VBD cord-005453-4057qib7 1318 5 the the DT cord-005453-4057qib7 1318 6 cytotoxic cytotoxic JJ cord-005453-4057qib7 1318 7 potential potential NN cord-005453-4057qib7 1318 8 of of IN cord-005453-4057qib7 1318 9 interleukin interleukin NN cord-005453-4057qib7 1318 10 ( ( -LRB- cord-005453-4057qib7 1318 11 IL)-activated il)-activated CD cord-005453-4057qib7 1318 12 natural natural JJ cord-005453-4057qib7 1318 13 killer killer NN cord-005453-4057qib7 1318 14 ( ( -LRB- cord-005453-4057qib7 1318 15 NK NK NNP cord-005453-4057qib7 1318 16 ) ) -RRB- cord-005453-4057qib7 1318 17 cells cell NNS cord-005453-4057qib7 1318 18 compared compare VBN cord-005453-4057qib7 1318 19 to to IN cord-005453-4057qib7 1318 20 activated activate VBN cord-005453-4057qib7 1318 21 cytokine cytokine NN cord-005453-4057qib7 1318 22 - - HYPH cord-005453-4057qib7 1318 23 induced induce VBN cord-005453-4057qib7 1318 24 killer killer NN cord-005453-4057qib7 1318 25 ( ( -LRB- cord-005453-4057qib7 1318 26 CIK CIK NNP cord-005453-4057qib7 1318 27 ) ) -RRB- cord-005453-4057qib7 1318 28 cells cell NNS cord-005453-4057qib7 1318 29 against against IN cord-005453-4057qib7 1318 30 different different JJ cord-005453-4057qib7 1318 31 human human JJ cord-005453-4057qib7 1318 32 NB NB NNP cord-005453-4057qib7 1318 33 cell cell NN cord-005453-4057qib7 1318 34 lines line NNS cord-005453-4057qib7 1318 35 in in IN cord-005453-4057qib7 1318 36 vitro vitro FW cord-005453-4057qib7 1318 37 . . . cord-005453-4057qib7 1319 1 Methods method NNS cord-005453-4057qib7 1319 2 : : : cord-005453-4057qib7 1319 3 NK NK NNP cord-005453-4057qib7 1319 4 cells cell NNS cord-005453-4057qib7 1319 5 were be VBD cord-005453-4057qib7 1319 6 isolated isolate VBN cord-005453-4057qib7 1319 7 from from IN cord-005453-4057qib7 1319 8 peripheral peripheral JJ cord-005453-4057qib7 1319 9 blood blood NN cord-005453-4057qib7 1319 10 mononuclear mononuclear NN cord-005453-4057qib7 1319 11 cells cell NNS cord-005453-4057qib7 1319 12 ( ( -LRB- cord-005453-4057qib7 1319 13 PBMCs pbmc NNS cord-005453-4057qib7 1319 14 ) ) -RRB- cord-005453-4057qib7 1319 15 using use VBG cord-005453-4057qib7 1319 16 CD56 CD56 NNP cord-005453-4057qib7 1319 17 enrichment enrichment NN cord-005453-4057qib7 1319 18 or or CC cord-005453-4057qib7 1319 19 CD3 CD3 NNP cord-005453-4057qib7 1319 20 / / SYM cord-005453-4057qib7 1319 21 CD19 CD19 NNP cord-005453-4057qib7 1319 22 depletion depletion NN cord-005453-4057qib7 1319 23 kits kit NNS cord-005453-4057qib7 1319 24 . . . cord-005453-4057qib7 1320 1 They -PRON- PRP cord-005453-4057qib7 1320 2 were be VBD cord-005453-4057qib7 1320 3 successfully successfully RB cord-005453-4057qib7 1320 4 expanded expand VBN cord-005453-4057qib7 1320 5 ex ex FW cord-005453-4057qib7 1320 6 vivo vivo NN cord-005453-4057qib7 1320 7 with with IN cord-005453-4057qib7 1320 8 different different JJ cord-005453-4057qib7 1320 9 cytokine cytokine NN cord-005453-4057qib7 1320 10 combinations combination NNS cord-005453-4057qib7 1320 11 such such JJ cord-005453-4057qib7 1320 12 as as IN cord-005453-4057qib7 1320 13 IL-2 IL-2 NNP cord-005453-4057qib7 1320 14 , , , cord-005453-4057qib7 1320 15 IL-15 IL-15 NNP cord-005453-4057qib7 1320 16 , , , cord-005453-4057qib7 1320 17 IL-18 IL-18 NNP cord-005453-4057qib7 1320 18 and/or and/or CC cord-005453-4057qib7 1320 19 IL-21 IL-21 NNP cord-005453-4057qib7 1320 20 under under IN cord-005453-4057qib7 1320 21 feeder feeder NN cord-005453-4057qib7 1320 22 - - HYPH cord-005453-4057qib7 1320 23 cell cell NN cord-005453-4057qib7 1320 24 free free JJ cord-005453-4057qib7 1320 25 conditions condition NNS cord-005453-4057qib7 1320 26 . . . cord-005453-4057qib7 1321 1 In in IN cord-005453-4057qib7 1321 2 contrast contrast NN cord-005453-4057qib7 1321 3 , , , cord-005453-4057qib7 1321 4 CIK CIK NNP cord-005453-4057qib7 1321 5 cells cell NNS cord-005453-4057qib7 1321 6 were be VBD cord-005453-4057qib7 1321 7 generated generate VBN cord-005453-4057qib7 1321 8 from from IN cord-005453-4057qib7 1321 9 PBMCs pbmc NNS cord-005453-4057qib7 1321 10 by by IN cord-005453-4057qib7 1321 11 ex ex FW cord-005453-4057qib7 1321 12 vivo vivo NN cord-005453-4057qib7 1321 13 stimulation stimulation NN cord-005453-4057qib7 1321 14 with with IN cord-005453-4057qib7 1321 15 interferon interferon NN cord-005453-4057qib7 1321 16 - - HYPH cord-005453-4057qib7 1321 17 γ γ NN cord-005453-4057qib7 1321 18 , , , cord-005453-4057qib7 1321 19 IL-2 IL-2 NNP cord-005453-4057qib7 1321 20 , , , cord-005453-4057qib7 1321 21 OKT-3 OKT-3 NNP cord-005453-4057qib7 1321 22 and and CC cord-005453-4057qib7 1321 23 IL-15 IL-15 NNP cord-005453-4057qib7 1321 24 . . . cord-005453-4057qib7 1322 1 A a DT cord-005453-4057qib7 1322 2 comparative comparative JJ cord-005453-4057qib7 1322 3 analysis analysis NN cord-005453-4057qib7 1322 4 of of IN cord-005453-4057qib7 1322 5 expansion expansion NN cord-005453-4057qib7 1322 6 rate rate NN cord-005453-4057qib7 1322 7 , , , cord-005453-4057qib7 1322 8 purity purity NN cord-005453-4057qib7 1322 9 , , , cord-005453-4057qib7 1322 10 phenotype phenotype NN cord-005453-4057qib7 1322 11 and and CC cord-005453-4057qib7 1322 12 cytotoxic cytotoxic JJ cord-005453-4057qib7 1322 13 activity activity NN cord-005453-4057qib7 1322 14 against against IN cord-005453-4057qib7 1322 15 different different JJ cord-005453-4057qib7 1322 16 NB NB NNP cord-005453-4057qib7 1322 17 cell cell NN cord-005453-4057qib7 1322 18 lines line NNS cord-005453-4057qib7 1322 19 following follow VBG cord-005453-4057qib7 1322 20 different different JJ cord-005453-4057qib7 1322 21 culturing culturing NN cord-005453-4057qib7 1322 22 protocols protocol NNS cord-005453-4057qib7 1322 23 was be VBD cord-005453-4057qib7 1322 24 performed perform VBN cord-005453-4057qib7 1322 25 . . . cord-005453-4057qib7 1323 1 Results result NNS cord-005453-4057qib7 1323 2 : : : cord-005453-4057qib7 1324 1 CD56 cd56 NN cord-005453-4057qib7 1324 2 enriched enrich VBN cord-005453-4057qib7 1324 3 NK NK NNP cord-005453-4057qib7 1324 4 cells cell NNS cord-005453-4057qib7 1324 5 showed show VBD cord-005453-4057qib7 1324 6 a a DT cord-005453-4057qib7 1324 7 median median JJ cord-005453-4057qib7 1324 8 expansion expansion NN cord-005453-4057qib7 1324 9 rate rate NN cord-005453-4057qib7 1324 10 of of IN cord-005453-4057qib7 1324 11 4.3-fold 4.3-fold CD cord-005453-4057qib7 1324 12 after after IN cord-005453-4057qib7 1324 13 10 10 CD cord-005453-4057qib7 1324 14 to to TO cord-005453-4057qib7 1324 15 12 12 CD cord-005453-4057qib7 1324 16 days day NNS cord-005453-4057qib7 1324 17 in in IN cord-005453-4057qib7 1324 18 culture culture NN cord-005453-4057qib7 1324 19 with with IN cord-005453-4057qib7 1324 20 a a DT cord-005453-4057qib7 1324 21 final final JJ cord-005453-4057qib7 1324 22 frequency frequency NN cord-005453-4057qib7 1324 23 up up IN cord-005453-4057qib7 1324 24 to to IN cord-005453-4057qib7 1324 25 99.0 99.0 CD cord-005453-4057qib7 1324 26 % % NN cord-005453-4057qib7 1324 27 NK NK NNP cord-005453-4057qib7 1324 28 cells cell NNS cord-005453-4057qib7 1324 29 and and CC cord-005453-4057qib7 1324 30 a a DT cord-005453-4057qib7 1324 31 median median JJ cord-005453-4057qib7 1324 32 frequency frequency NN cord-005453-4057qib7 1324 33 of of IN cord-005453-4057qib7 1324 34 0.5 0.5 CD cord-005453-4057qib7 1324 35 % % NN cord-005453-4057qib7 1324 36 CD3 CD3 NNP cord-005453-4057qib7 1324 37 + + CC cord-005453-4057qib7 1324 38 CD56 CD56 NNP cord-005453-4057qib7 1324 39 -T -T : cord-005453-4057qib7 1324 40 cells cell NNS cord-005453-4057qib7 1324 41 . . . cord-005453-4057qib7 1325 1 In in IN cord-005453-4057qib7 1325 2 contrast contrast NN cord-005453-4057qib7 1325 3 , , , cord-005453-4057qib7 1325 4 the the DT cord-005453-4057qib7 1325 5 starting start VBG cord-005453-4057qib7 1325 6 cell cell NN cord-005453-4057qib7 1325 7 product product NN cord-005453-4057qib7 1325 8 after after IN cord-005453-4057qib7 1325 9 CD3 CD3 NNP cord-005453-4057qib7 1325 10 / / SYM cord-005453-4057qib7 1325 11 CD19 CD19 NNP cord-005453-4057qib7 1325 12 depletion depletion NN cord-005453-4057qib7 1325 13 consisted consist VBD cord-005453-4057qib7 1325 14 of of IN cord-005453-4057qib7 1325 15 a a DT cord-005453-4057qib7 1325 16 median median JJ cord-005453-4057qib7 1325 17 frequency frequency NN cord-005453-4057qib7 1325 18 of of IN cord-005453-4057qib7 1325 19 43.5 43.5 CD cord-005453-4057qib7 1325 20 % % NN cord-005453-4057qib7 1325 21 NK NK NNP cord-005453-4057qib7 1325 22 cells cell NNS cord-005453-4057qib7 1325 23 that that WDT cord-005453-4057qib7 1325 24 expanded expand VBD cord-005453-4057qib7 1325 25 significantly significantly RB cord-005453-4057qib7 1325 26 faster fast RBR cord-005453-4057qib7 1325 27 with with IN cord-005453-4057qib7 1325 28 7.5-fold 7.5-fold CD cord-005453-4057qib7 1325 29 and and CC cord-005453-4057qib7 1325 30 also also RB cord-005453-4057qib7 1325 31 reached reach VBD cord-005453-4057qib7 1325 32 up up RP cord-005453-4057qib7 1325 33 to to IN cord-005453-4057qib7 1325 34 98.6 98.6 CD cord-005453-4057qib7 1325 35 % % NN cord-005453-4057qib7 1325 36 purity purity NN cord-005453-4057qib7 1325 37 without without IN cord-005453-4057qib7 1325 38 any any DT cord-005453-4057qib7 1325 39 relevant relevant JJ cord-005453-4057qib7 1325 40 T t NN cord-005453-4057qib7 1325 41 cell cell NN cord-005453-4057qib7 1325 42 contamination contamination NN cord-005453-4057qib7 1325 43 . . . cord-005453-4057qib7 1326 1 CIK CIK NNP cord-005453-4057qib7 1326 2 cells cell NNS cord-005453-4057qib7 1326 3 expanded expand VBN cord-005453-4057qib7 1326 4 with with IN cord-005453-4057qib7 1326 5 a a DT cord-005453-4057qib7 1326 6 median median JJ cord-005453-4057qib7 1326 7 rate rate NN cord-005453-4057qib7 1326 8 of of IN cord-005453-4057qib7 1326 9 30.8-fold 30.8-fold CD cord-005453-4057qib7 1326 10 and and CC cord-005453-4057qib7 1326 11 contained contain VBD cord-005453-4057qib7 1326 12 3.3 3.3 CD cord-005453-4057qib7 1326 13 % % NN cord-005453-4057qib7 1326 14 NK NK NNP cord-005453-4057qib7 1326 15 , , , cord-005453-4057qib7 1326 16 84.2 84.2 CD cord-005453-4057qib7 1326 17 % % NN cord-005453-4057qib7 1326 18 T t NN cord-005453-4057qib7 1326 19 and and CC cord-005453-4057qib7 1326 20 6.2 6.2 CD cord-005453-4057qib7 1326 21 % % NN cord-005453-4057qib7 1326 22 NK nk NN cord-005453-4057qib7 1326 23 - - HYPH cord-005453-4057qib7 1326 24 like like NNP cord-005453-4057qib7 1326 25 T t NN cord-005453-4057qib7 1326 26 cells cell NNS cord-005453-4057qib7 1326 27 . . . cord-005453-4057qib7 1327 1 Interestingly interestingly RB cord-005453-4057qib7 1327 2 , , , cord-005453-4057qib7 1327 3 NK NK NNP cord-005453-4057qib7 1327 4 cells cell NNS cord-005453-4057qib7 1327 5 , , , cord-005453-4057qib7 1327 6 particularly particularly RB cord-005453-4057qib7 1327 7 after after IN cord-005453-4057qib7 1327 8 CD3 CD3 NNP cord-005453-4057qib7 1327 9 / / SYM cord-005453-4057qib7 1327 10 CD19 CD19 NNP cord-005453-4057qib7 1327 11 , , , cord-005453-4057qib7 1327 12 showed show VBD cord-005453-4057qib7 1327 13 a a DT cord-005453-4057qib7 1327 14 significantly significantly RB cord-005453-4057qib7 1327 15 higher high JJR cord-005453-4057qib7 1327 16 median median JJ cord-005453-4057qib7 1327 17 cytotoxic cytotoxic JJ cord-005453-4057qib7 1327 18 capacity capacity NN cord-005453-4057qib7 1327 19 against against IN cord-005453-4057qib7 1327 20 NB NB NNP cord-005453-4057qib7 1327 21 cells cell NNS cord-005453-4057qib7 1327 22 depletion depletion NN cord-005453-4057qib7 1327 23 ( ( -LRB- cord-005453-4057qib7 1327 24 46.6 46.6 CD cord-005453-4057qib7 1327 25 % % NN cord-005453-4057qib7 1327 26 for for IN cord-005453-4057qib7 1327 27 CD56 CD56 NNP cord-005453-4057qib7 1327 28 enrichment enrichment NN cord-005453-4057qib7 1327 29 , , , cord-005453-4057qib7 1327 30 53.7 53.7 CD cord-005453-4057qib7 1327 31 % % NN cord-005453-4057qib7 1327 32 for for IN cord-005453-4057qib7 1327 33 CD3 CD3 NNP cord-005453-4057qib7 1327 34 / / SYM cord-005453-4057qib7 1327 35 CD19 CD19 NNP cord-005453-4057qib7 1327 36 depletion depletion NN cord-005453-4057qib7 1327 37 ) ) -RRB- cord-005453-4057qib7 1327 38 compared compare VBN cord-005453-4057qib7 1327 39 to to IN cord-005453-4057qib7 1327 40 CIK CIK NNP cord-005453-4057qib7 1327 41 cells cell NNS cord-005453-4057qib7 1327 42 that that WDT cord-005453-4057qib7 1327 43 induced induce VBD cord-005453-4057qib7 1327 44 7.2 7.2 CD cord-005453-4057qib7 1327 45 % % NN cord-005453-4057qib7 1327 46 killing killing NN cord-005453-4057qib7 1327 47 of of IN cord-005453-4057qib7 1327 48 NB NB NNP cord-005453-4057qib7 1327 49 cells cell NNS cord-005453-4057qib7 1327 50 with with IN cord-005453-4057qib7 1327 51 E e NN cord-005453-4057qib7 1327 52 : : : cord-005453-4057qib7 1327 53 T t NN cord-005453-4057qib7 1327 54 ratio ratio NN cord-005453-4057qib7 1327 55 5:1 5:1 CD cord-005453-4057qib7 1327 56 in in IN cord-005453-4057qib7 1327 57 a a DT cord-005453-4057qib7 1327 58 3 3 CD cord-005453-4057qib7 1327 59 hours hour NNS cord-005453-4057qib7 1327 60 ' ' POS cord-005453-4057qib7 1327 61 co co NN cord-005453-4057qib7 1327 62 - - JJ cord-005453-4057qib7 1327 63 incubation incubation JJ cord-005453-4057qib7 1327 64 assay assay NN cord-005453-4057qib7 1327 65 . . . cord-005453-4057qib7 1328 1 Interestingly interestingly RB cord-005453-4057qib7 1328 2 , , , cord-005453-4057qib7 1328 3 prolonging prolong VBG cord-005453-4057qib7 1328 4 the the DT cord-005453-4057qib7 1328 5 ex ex FW cord-005453-4057qib7 1328 6 vivo vivo NN cord-005453-4057qib7 1328 7 stimulation stimulation NN cord-005453-4057qib7 1328 8 after after IN cord-005453-4057qib7 1328 9 CD3 CD3 NNP cord-005453-4057qib7 1328 10 / / SYM cord-005453-4057qib7 1328 11 CD19 CD19 NNP cord-005453-4057qib7 1328 12 depletion depletion NN cord-005453-4057qib7 1328 13 to to IN cord-005453-4057qib7 1328 14 15 15 CD cord-005453-4057qib7 1328 15 days day NNS cord-005453-4057qib7 1328 16 enhanced enhance VBD cord-005453-4057qib7 1328 17 the the DT cord-005453-4057qib7 1328 18 median median JJ cord-005453-4057qib7 1328 19 expansion expansion NN cord-005453-4057qib7 1328 20 rate rate NN cord-005453-4057qib7 1328 21 to to IN cord-005453-4057qib7 1328 22 12.3-fold 12.3-fold CD cord-005453-4057qib7 1328 23 with with IN cord-005453-4057qib7 1328 24 a a DT cord-005453-4057qib7 1328 25 slightly slightly RB cord-005453-4057qib7 1328 26 reduced reduce VBN cord-005453-4057qib7 1328 27 cytotoxic cytotoxic JJ cord-005453-4057qib7 1328 28 potential potential NN cord-005453-4057qib7 1328 29 ( ( -LRB- cord-005453-4057qib7 1328 30 40.9 40.9 CD cord-005453-4057qib7 1328 31 % % NN cord-005453-4057qib7 1328 32 for for IN cord-005453-4057qib7 1328 33 11 11 CD cord-005453-4057qib7 1328 34 days day NNS cord-005453-4057qib7 1328 35 ' ' POS cord-005453-4057qib7 1328 36 ex ex NN cord-005453-4057qib7 1328 37 vivo vivo NN cord-005453-4057qib7 1328 38 expansion expansion NN cord-005453-4057qib7 1328 39 , , , cord-005453-4057qib7 1328 40 31.1 31.1 CD cord-005453-4057qib7 1328 41 % % NN cord-005453-4057qib7 1328 42 for for IN cord-005453-4057qib7 1328 43 15 15 CD cord-005453-4057qib7 1328 44 days day NNS cord-005453-4057qib7 1328 45 ' ' POS cord-005453-4057qib7 1328 46 ex ex NN cord-005453-4057qib7 1328 47 vivo vivo NN cord-005453-4057qib7 1328 48 expansion expansion NN cord-005453-4057qib7 1328 49 , , , cord-005453-4057qib7 1328 50 comparison comparison NN cord-005453-4057qib7 1328 51 of of IN cord-005453-4057qib7 1328 52 the the DT cord-005453-4057qib7 1328 53 same same JJ cord-005453-4057qib7 1328 54 donors donor NNS cord-005453-4057qib7 1328 55 ) ) -RRB- cord-005453-4057qib7 1328 56 . . . cord-005453-4057qib7 1329 1 The the DT cord-005453-4057qib7 1329 2 addition addition NN cord-005453-4057qib7 1329 3 of of IN cord-005453-4057qib7 1329 4 an an DT cord-005453-4057qib7 1329 5 IL21boost IL21boost NNP cord-005453-4057qib7 1329 6 prior prior JJ cord-005453-4057qib7 1329 7 harvesting harvesting NN cord-005453-4057qib7 1329 8 increased increase VBD cord-005453-4057qib7 1329 9 the the DT cord-005453-4057qib7 1329 10 expansion expansion NN cord-005453-4057qib7 1329 11 rate rate NN cord-005453-4057qib7 1329 12 to to IN cord-005453-4057qib7 1329 13 median median JJ cord-005453-4057qib7 1329 14 12.6-fold 12.6-fold CD cord-005453-4057qib7 1329 15 ( ( -LRB- cord-005453-4057qib7 1329 16 compared compare VBN cord-005453-4057qib7 1329 17 to to IN cord-005453-4057qib7 1329 18 11.7-fold 11.7-fold CD cord-005453-4057qib7 1329 19 for for IN cord-005453-4057qib7 1329 20 the the DT cord-005453-4057qib7 1329 21 same same JJ cord-005453-4057qib7 1329 22 donors donor NNS cord-005453-4057qib7 1329 23 ) ) -RRB- cord-005453-4057qib7 1329 24 with with IN cord-005453-4057qib7 1329 25 an an DT cord-005453-4057qib7 1329 26 improved improved JJ cord-005453-4057qib7 1329 27 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1329 28 of of IN cord-005453-4057qib7 1329 29 51.5 51.5 CD cord-005453-4057qib7 1329 30 % % NN cord-005453-4057qib7 1329 31 ( ( -LRB- cord-005453-4057qib7 1329 32 compared compare VBN cord-005453-4057qib7 1329 33 to to IN cord-005453-4057qib7 1329 34 45.8 45.8 CD cord-005453-4057qib7 1329 35 % % NN cord-005453-4057qib7 1329 36 ) ) -RRB- cord-005453-4057qib7 1329 37 . . . cord-005453-4057qib7 1330 1 Fortunately fortunately RB cord-005453-4057qib7 1330 2 , , , cord-005453-4057qib7 1330 3 all all DT cord-005453-4057qib7 1330 4 NK NK NNP cord-005453-4057qib7 1330 5 cell cell NN cord-005453-4057qib7 1330 6 products product NNS cord-005453-4057qib7 1330 7 showed show VBD cord-005453-4057qib7 1330 8 a a DT cord-005453-4057qib7 1330 9 high high JJ cord-005453-4057qib7 1330 10 viability viability NN cord-005453-4057qib7 1330 11 and and CC cord-005453-4057qib7 1330 12 no no DT cord-005453-4057qib7 1330 13 relevant relevant JJ cord-005453-4057qib7 1330 14 T t NN cord-005453-4057qib7 1330 15 or or CC cord-005453-4057qib7 1330 16 B b NN cord-005453-4057qib7 1330 17 cell cell NN cord-005453-4057qib7 1330 18 contamination contamination NN cord-005453-4057qib7 1330 19 ( ( -LRB- cord-005453-4057qib7 1330 20 median median NN cord-005453-4057qib7 1330 21 < < XX cord-005453-4057qib7 1330 22 0.2 0.2 CD cord-005453-4057qib7 1330 23 % % NN cord-005453-4057qib7 1330 24 ) ) -RRB- cord-005453-4057qib7 1330 25 . . . cord-005453-4057qib7 1331 1 Interestingly interestingly RB cord-005453-4057qib7 1331 2 , , , cord-005453-4057qib7 1331 3 further further JJ cord-005453-4057qib7 1331 4 optimization optimization NN cord-005453-4057qib7 1331 5 of of IN cord-005453-4057qib7 1331 6 the the DT cord-005453-4057qib7 1331 7 culturing culturing NN cord-005453-4057qib7 1331 8 procedure procedure NN cord-005453-4057qib7 1331 9 with with IN cord-005453-4057qib7 1331 10 use use NN cord-005453-4057qib7 1331 11 of of IN cord-005453-4057qib7 1331 12 another another DT cord-005453-4057qib7 1331 13 cell cell NN cord-005453-4057qib7 1331 14 culture culture NN cord-005453-4057qib7 1331 15 medium medium NN cord-005453-4057qib7 1331 16 led lead VBD cord-005453-4057qib7 1331 17 to to IN cord-005453-4057qib7 1331 18 an an DT cord-005453-4057qib7 1331 19 improved improved JJ cord-005453-4057qib7 1331 20 median median JJ cord-005453-4057qib7 1331 21 24.4-fold 24.4-fold CD cord-005453-4057qib7 1331 22 ( ( -LRB- cord-005453-4057qib7 1331 23 compared compare VBN cord-005453-4057qib7 1331 24 to to IN cord-005453-4057qib7 1331 25 9.6-fold 9.6-fold CD cord-005453-4057qib7 1331 26 ) ) -RRB- cord-005453-4057qib7 1332 1 NK NK NNP cord-005453-4057qib7 1332 2 cell cell NN cord-005453-4057qib7 1332 3 expansion expansion NN cord-005453-4057qib7 1332 4 rate rate NN cord-005453-4057qib7 1332 5 in in IN cord-005453-4057qib7 1332 6 15 15 CD cord-005453-4057qib7 1332 7 days day NNS cord-005453-4057qib7 1332 8 , , , cord-005453-4057qib7 1332 9 also also RB cord-005453-4057qib7 1332 10 resulting result VBG cord-005453-4057qib7 1332 11 in in IN cord-005453-4057qib7 1332 12 comparable comparable JJ cord-005453-4057qib7 1332 13 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1332 14 of of IN cord-005453-4057qib7 1332 15 52.5 52.5 CD cord-005453-4057qib7 1332 16 % % NN cord-005453-4057qib7 1332 17 . . . cord-005453-4057qib7 1333 1 Conclusions conclusion NNS cord-005453-4057qib7 1333 2 : : : cord-005453-4057qib7 1334 1 NK NK NNP cord-005453-4057qib7 1334 2 and and CC cord-005453-4057qib7 1334 3 CIK CIK NNP cord-005453-4057qib7 1334 4 cell cell NN cord-005453-4057qib7 1334 5 products product NNS cord-005453-4057qib7 1334 6 may may MD cord-005453-4057qib7 1334 7 offer offer VB cord-005453-4057qib7 1334 8 an an DT cord-005453-4057qib7 1334 9 innovative innovative JJ cord-005453-4057qib7 1334 10 immune immune JJ cord-005453-4057qib7 1334 11 therapeutic therapeutic JJ cord-005453-4057qib7 1334 12 option option NN cord-005453-4057qib7 1334 13 for for IN cord-005453-4057qib7 1334 14 patients patient NNS cord-005453-4057qib7 1334 15 with with IN cord-005453-4057qib7 1334 16 high high JJ cord-005453-4057qib7 1334 17 - - HYPH cord-005453-4057qib7 1334 18 risk risk NN cord-005453-4057qib7 1334 19 NB NB NNP cord-005453-4057qib7 1334 20 after after IN cord-005453-4057qib7 1334 21 allogenic allogenic JJ cord-005453-4057qib7 1334 22 stem stem NN cord-005453-4057qib7 1334 23 cell cell NN cord-005453-4057qib7 1334 24 transplantation transplantation NN cord-005453-4057qib7 1334 25 . . . cord-005453-4057qib7 1335 1 Our -PRON- PRP$ cord-005453-4057qib7 1335 2 study study NN cord-005453-4057qib7 1335 3 revealed reveal VBD cord-005453-4057qib7 1335 4 that that IN cord-005453-4057qib7 1335 5 NK NK NNP cord-005453-4057qib7 1335 6 cells cell NNS cord-005453-4057qib7 1335 7 have have VBP cord-005453-4057qib7 1335 8 a a DT cord-005453-4057qib7 1335 9 significantly significantly RB cord-005453-4057qib7 1335 10 higher high JJR cord-005453-4057qib7 1335 11 cytotoxic cytotoxic JJ cord-005453-4057qib7 1335 12 potential potential NN cord-005453-4057qib7 1335 13 to to TO cord-005453-4057qib7 1335 14 combat combat NN cord-005453-4057qib7 1335 15 NB NB NNP cord-005453-4057qib7 1335 16 . . . cord-005453-4057qib7 1336 1 Interestingly interestingly RB cord-005453-4057qib7 1336 2 , , , cord-005453-4057qib7 1336 3 the the DT cord-005453-4057qib7 1336 4 use use NN cord-005453-4057qib7 1336 5 of of IN cord-005453-4057qib7 1336 6 IL-15 IL-15 NNP cord-005453-4057qib7 1336 7 expanded expand VBD cord-005453-4057qib7 1336 8 and and CC cord-005453-4057qib7 1336 9 IL-21 IL-21 NNP cord-005453-4057qib7 1336 10 activated activate VBD cord-005453-4057qib7 1336 11 NK NK NNP cord-005453-4057qib7 1336 12 cells cell NNS cord-005453-4057qib7 1336 13 developed develop VBN cord-005453-4057qib7 1336 14 from from IN cord-005453-4057qib7 1336 15 a a DT cord-005453-4057qib7 1336 16 CD3/19 cd3/19 NN cord-005453-4057qib7 1336 17 depleted deplete VBN cord-005453-4057qib7 1336 18 apheresis apheresis NN cord-005453-4057qib7 1336 19 product product NN cord-005453-4057qib7 1336 20 is be VBZ cord-005453-4057qib7 1336 21 highly highly RB cord-005453-4057qib7 1336 22 promising promising JJ cord-005453-4057qib7 1336 23 as as IN cord-005453-4057qib7 1336 24 additional additional JJ cord-005453-4057qib7 1336 25 immunotherapy immunotherapy NN cord-005453-4057qib7 1336 26 in in IN cord-005453-4057qib7 1336 27 combination combination NN cord-005453-4057qib7 1336 28 with with IN cord-005453-4057qib7 1336 29 haploidentical haploidentical JJ cord-005453-4057qib7 1336 30 stem stem NN cord-005453-4057qib7 1336 31 cell cell NN cord-005453-4057qib7 1336 32 transplantation transplantation NN cord-005453-4057qib7 1336 33 of of IN cord-005453-4057qib7 1336 34 children child NNS cord-005453-4057qib7 1336 35 with with IN cord-005453-4057qib7 1336 36 NB NB NNP cord-005453-4057qib7 1336 37 . . . cord-005453-4057qib7 1337 1 Disclosure disclosure NN cord-005453-4057qib7 1337 2 : : : cord-005453-4057qib7 1337 3 Nothing nothing NN cord-005453-4057qib7 1337 4 to to TO cord-005453-4057qib7 1337 5 declare declare VB cord-005453-4057qib7 1337 6 . . . cord-005453-4057qib7 1338 1 Quantitative quantitative JJ cord-005453-4057qib7 1338 2 determination determination NN cord-005453-4057qib7 1338 3 of of IN cord-005453-4057qib7 1338 4 donor donor NN cord-005453-4057qib7 1338 5 allo allo NN cord-005453-4057qib7 1338 6 - - HYPH cord-005453-4057qib7 1338 7 reactive reactive JJ cord-005453-4057qib7 1338 8 T T NNP cord-005453-4057qib7 1338 9 - - HYPH cord-005453-4057qib7 1338 10 cells cell NNS cord-005453-4057qib7 1338 11 in in IN cord-005453-4057qib7 1338 12 haploidentical haploidentical JJ cord-005453-4057qib7 1338 13 donor donor NN cord-005453-4057qib7 1338 14 - - HYPH cord-005453-4057qib7 1338 15 recipient recipient NN cord-005453-4057qib7 1338 16 pairs pair NNS cord-005453-4057qib7 1338 17 by by IN cord-005453-4057qib7 1338 18 enzymelinked enzymelinked NNP cord-005453-4057qib7 1338 19 immunospot immunospot NNP cord-005453-4057qib7 1338 20 ( ( -LRB- cord-005453-4057qib7 1338 21 ELISPOT ELISPOT NNP cord-005453-4057qib7 1338 22 ) ) -RRB- cord-005453-4057qib7 1338 23 and and CC cord-005453-4057qib7 1338 24 mixed mixed JJ cord-005453-4057qib7 1338 25 lymphocyte lymphocyte NN cord-005453-4057qib7 1338 26 culture culture NN cord-005453-4057qib7 1339 1 ( ( -LRB- cord-005453-4057qib7 1339 2 MLC MLC NNP cord-005453-4057qib7 1339 3 ) ) -RRB- cord-005453-4057qib7 1339 4 assays assays NNP cord-005453-4057qib7 1340 1 Background background NN cord-005453-4057qib7 1340 2 : : : cord-005453-4057qib7 1341 1 T t NN cord-005453-4057qib7 1341 2 - - HYPH cord-005453-4057qib7 1341 3 cell cell NN cord-005453-4057qib7 1341 4 alloreactivity alloreactivity NN cord-005453-4057qib7 1341 5 is be VBZ cord-005453-4057qib7 1341 6 responsible responsible JJ cord-005453-4057qib7 1341 7 not not RB cord-005453-4057qib7 1341 8 only only RB cord-005453-4057qib7 1341 9 for for IN cord-005453-4057qib7 1341 10 graft graft NN cord-005453-4057qib7 1341 11 versus versus IN cord-005453-4057qib7 1341 12 host host NN cord-005453-4057qib7 1341 13 disease disease NN cord-005453-4057qib7 1341 14 and and CC cord-005453-4057qib7 1341 15 morbidity morbidity NN cord-005453-4057qib7 1341 16 , , , cord-005453-4057qib7 1341 17 associated associate VBN cord-005453-4057qib7 1341 18 with with IN cord-005453-4057qib7 1341 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 1341 20 stem stem NN cord-005453-4057qib7 1341 21 cell cell NN cord-005453-4057qib7 1341 22 transplantation transplantation NN cord-005453-4057qib7 1341 23 ( ( -LRB- cord-005453-4057qib7 1341 24 HSCT HSCT NNP cord-005453-4057qib7 1341 25 ) ) -RRB- cord-005453-4057qib7 1341 26 but but CC cord-005453-4057qib7 1341 27 also also RB cord-005453-4057qib7 1341 28 for for IN cord-005453-4057qib7 1341 29 graft graft NN cord-005453-4057qib7 1341 30 - - HYPH cord-005453-4057qib7 1341 31 versus versus IN cord-005453-4057qib7 1341 32 - - HYPH cord-005453-4057qib7 1341 33 leukemia leukemia NN cord-005453-4057qib7 1341 34 ( ( -LRB- cord-005453-4057qib7 1341 35 GVL gvl NN cord-005453-4057qib7 1341 36 ) ) -RRB- cord-005453-4057qib7 1341 37 activity activity NN cord-005453-4057qib7 1341 38 . . . cord-005453-4057qib7 1342 1 In in IN cord-005453-4057qib7 1342 2 this this DT cord-005453-4057qib7 1342 3 regard regard NN cord-005453-4057qib7 1342 4 , , , cord-005453-4057qib7 1342 5 monitoring monitoring NN cord-005453-4057qib7 1342 6 and and CC cord-005453-4057qib7 1342 7 quantitation quantitation NN cord-005453-4057qib7 1342 8 of of IN cord-005453-4057qib7 1342 9 alloreactive alloreactive NNP cord-005453-4057qib7 1342 10 T T NNP cord-005453-4057qib7 1342 11 - - HYPH cord-005453-4057qib7 1342 12 cells cell NNS cord-005453-4057qib7 1342 13 ( ( -LRB- cord-005453-4057qib7 1342 14 allo allo NN cord-005453-4057qib7 1342 15 - - HYPH cord-005453-4057qib7 1342 16 T T NNP cord-005453-4057qib7 1342 17 ) ) -RRB- cord-005453-4057qib7 1342 18 may may MD cord-005453-4057qib7 1342 19 potentially potentially RB cord-005453-4057qib7 1342 20 provide provide VB cord-005453-4057qib7 1342 21 valuable valuable JJ cord-005453-4057qib7 1342 22 information information NN cord-005453-4057qib7 1342 23 for for IN cord-005453-4057qib7 1342 24 individualized individualized JJ cord-005453-4057qib7 1342 25 clinical clinical JJ cord-005453-4057qib7 1342 26 management management NN cord-005453-4057qib7 1342 27 of of IN cord-005453-4057qib7 1342 28 transplant transplant NN cord-005453-4057qib7 1342 29 recipients recipient NNS cord-005453-4057qib7 1342 30 . . . cord-005453-4057qib7 1343 1 The the DT cord-005453-4057qib7 1343 2 aim aim NN cord-005453-4057qib7 1343 3 of of IN cord-005453-4057qib7 1343 4 this this DT cord-005453-4057qib7 1343 5 study study NN cord-005453-4057qib7 1343 6 was be VBD cord-005453-4057qib7 1343 7 the the DT cord-005453-4057qib7 1343 8 optimization optimization NN cord-005453-4057qib7 1343 9 of of IN cord-005453-4057qib7 1343 10 allo allo NN cord-005453-4057qib7 1343 11 - - HYPH cord-005453-4057qib7 1343 12 Т т NN cord-005453-4057qib7 1343 13 detection detection NN cord-005453-4057qib7 1343 14 and and CC cord-005453-4057qib7 1343 15 comparison comparison NN cord-005453-4057qib7 1343 16 of of IN cord-005453-4057qib7 1343 17 the the DT cord-005453-4057qib7 1343 18 ELISPOT ELISPOT NNP cord-005453-4057qib7 1343 19 and and CC cord-005453-4057qib7 1343 20 MLC MLC NNP cord-005453-4057qib7 1343 21 assays assay NNS cord-005453-4057qib7 1343 22 . . . cord-005453-4057qib7 1344 1 Methods method NNS cord-005453-4057qib7 1344 2 : : : cord-005453-4057qib7 1345 1 Allo Allo NNP cord-005453-4057qib7 1345 2 - - HYPH cord-005453-4057qib7 1345 3 T T NNP cord-005453-4057qib7 1345 4 were be VBD cord-005453-4057qib7 1345 5 determined determine VBN cord-005453-4057qib7 1345 6 in in IN cord-005453-4057qib7 1345 7 20 20 CD cord-005453-4057qib7 1345 8 haploidentical haploidentical JJ cord-005453-4057qib7 1345 9 donor donor NN cord-005453-4057qib7 1345 10 - - HYPH cord-005453-4057qib7 1345 11 recipient recipient NN cord-005453-4057qib7 1345 12 pairs pair NNS cord-005453-4057qib7 1345 13 before before IN cord-005453-4057qib7 1345 14 HSCT HSCT NNP cord-005453-4057qib7 1345 15 . . . cord-005453-4057qib7 1346 1 Donor donor NN cord-005453-4057qib7 1346 2 mononuclear mononuclear NN cord-005453-4057qib7 1346 3 cells cell NNS cord-005453-4057qib7 1346 4 ( ( -LRB- cord-005453-4057qib7 1346 5 MNC MNC NNP cord-005453-4057qib7 1346 6 ) ) -RRB- cord-005453-4057qib7 1346 7 served serve VBD cord-005453-4057qib7 1346 8 as as IN cord-005453-4057qib7 1346 9 effector effector NN cord-005453-4057qib7 1346 10 cells cell NNS cord-005453-4057qib7 1346 11 ( ( -LRB- cord-005453-4057qib7 1346 12 EC EC NNP cord-005453-4057qib7 1346 13 ) ) -RRB- cord-005453-4057qib7 1346 14 . . . cord-005453-4057qib7 1347 1 Patient Patient NNP cord-005453-4057qib7 1347 2 CD3depleted CD3depleted NNP cord-005453-4057qib7 1347 3 MNC MNC NNP cord-005453-4057qib7 1347 4 were be VBD cord-005453-4057qib7 1347 5 used use VBN cord-005453-4057qib7 1347 6 as as IN cord-005453-4057qib7 1347 7 stimulatory stimulatory JJ cord-005453-4057qib7 1347 8 cells cell NNS cord-005453-4057qib7 1347 9 ( ( -LRB- cord-005453-4057qib7 1347 10 SC).The SC).The NNP cord-005453-4057qib7 1347 11 ratio ratio NN cord-005453-4057qib7 1347 12 EC EC NNP cord-005453-4057qib7 1347 13 : : : cord-005453-4057qib7 1347 14 SC SC NNP cord-005453-4057qib7 1347 15 were be VBD cord-005453-4057qib7 1347 16 5:1 5:1 CD cord-005453-4057qib7 1347 17 and and CC cord-005453-4057qib7 1347 18 10:1 10:1 CD cord-005453-4057qib7 1347 19 . . . cord-005453-4057qib7 1348 1 The the DT cord-005453-4057qib7 1348 2 frequency frequency NN cord-005453-4057qib7 1348 3 of of IN cord-005453-4057qib7 1348 4 allo allo NN cord-005453-4057qib7 1348 5 - - HYPH cord-005453-4057qib7 1348 6 T t NN cord-005453-4057qib7 1348 7 in in IN cord-005453-4057qib7 1348 8 donor donor NN cord-005453-4057qib7 1348 9 peripheral peripheral JJ cord-005453-4057qib7 1348 10 blood blood NN cord-005453-4057qib7 1348 11 was be VBD cord-005453-4057qib7 1348 12 tested test VBN cord-005453-4057qib7 1348 13 in in IN cord-005453-4057qib7 1348 14 ELISPOT ELISPOT NNP cord-005453-4057qib7 1348 15 assay assay NN cord-005453-4057qib7 1348 16 and and CC cord-005453-4057qib7 1348 17 MLC MLC NNP cord-005453-4057qib7 1348 18 . . . cord-005453-4057qib7 1349 1 ELISPOT ELISPOT NNP cord-005453-4057qib7 1349 2 provides provide VBZ cord-005453-4057qib7 1349 3 the the DT cord-005453-4057qib7 1349 4 detection detection NN cord-005453-4057qib7 1349 5 and and CC cord-005453-4057qib7 1349 6 quantitation quantitation NN cord-005453-4057qib7 1349 7 of of IN cord-005453-4057qib7 1349 8 activated activate VBN cord-005453-4057qib7 1349 9 T T NNP cord-005453-4057qib7 1349 10 - - HYPH cord-005453-4057qib7 1349 11 cells cell NNS cord-005453-4057qib7 1349 12 on on IN cord-005453-4057qib7 1349 13 the the DT cord-005453-4057qib7 1349 14 basis basis NN cord-005453-4057qib7 1349 15 of of IN cord-005453-4057qib7 1349 16 cytokine cytokine NN cord-005453-4057qib7 1349 17 secreted secrete VBN cord-005453-4057qib7 1349 18 by by IN cord-005453-4057qib7 1349 19 each each DT cord-005453-4057qib7 1349 20 cell cell NN cord-005453-4057qib7 1349 21 . . . cord-005453-4057qib7 1350 1 The the DT cord-005453-4057qib7 1350 2 co co NN cord-005453-4057qib7 1350 3 - - JJ cord-005453-4057qib7 1350 4 incubation incubation JJ cord-005453-4057qib7 1350 5 time time NN cord-005453-4057qib7 1350 6 was be VBD cord-005453-4057qib7 1350 7 24 24 CD cord-005453-4057qib7 1350 8 h h NN cord-005453-4057qib7 1350 9 for for IN cord-005453-4057qib7 1350 10 IFN IFN NNP cord-005453-4057qib7 1350 11 - - HYPH cord-005453-4057qib7 1350 12 gamma gamma NNP cord-005453-4057qib7 1350 13 and and CC cord-005453-4057qib7 1350 14 48 48 CD cord-005453-4057qib7 1350 15 h h NN cord-005453-4057qib7 1350 16 for for IN cord-005453-4057qib7 1350 17 IL-2 IL-2 NNP cord-005453-4057qib7 1350 18 detection detection NN cord-005453-4057qib7 1350 19 . . . cord-005453-4057qib7 1351 1 In in IN cord-005453-4057qib7 1351 2 MCL MCL NNP cord-005453-4057qib7 1351 3 assay assay NN cord-005453-4057qib7 1351 4 donor donor NN cord-005453-4057qib7 1351 5 MNC MNC NNP cord-005453-4057qib7 1351 6 were be VBD cord-005453-4057qib7 1351 7 labeled label VBN cord-005453-4057qib7 1351 8 with with IN cord-005453-4057qib7 1351 9 CFSE CFSE NNP cord-005453-4057qib7 1351 10 and and CC cord-005453-4057qib7 1351 11 allo allo NNP cord-005453-4057qib7 1351 12 - - HYPH cord-005453-4057qib7 1351 13 T t NN cord-005453-4057qib7 1351 14 , , , cord-005453-4057qib7 1351 15 proliferating proliferate VBG cord-005453-4057qib7 1351 16 in in IN cord-005453-4057qib7 1351 17 response response NN cord-005453-4057qib7 1351 18 to to IN cord-005453-4057qib7 1351 19 stimulation stimulation NN cord-005453-4057qib7 1351 20 with with IN cord-005453-4057qib7 1351 21 alloantigens alloantigens NNP cord-005453-4057qib7 1351 22 , , , cord-005453-4057qib7 1351 23 were be VBD cord-005453-4057qib7 1351 24 determined determine VBN cord-005453-4057qib7 1351 25 by by IN cord-005453-4057qib7 1351 26 flow flow NN cord-005453-4057qib7 1351 27 cytometry cytometry NN cord-005453-4057qib7 1351 28 on on IN cord-005453-4057qib7 1351 29 day day NN cord-005453-4057qib7 1351 30 5 5 CD cord-005453-4057qib7 1351 31 . . . cord-005453-4057qib7 1352 1 Results result NNS cord-005453-4057qib7 1352 2 : : : cord-005453-4057qib7 1353 1 The the DT cord-005453-4057qib7 1353 2 median median JJ cord-005453-4057qib7 1353 3 number number NN cord-005453-4057qib7 1353 4 of of IN cord-005453-4057qib7 1353 5 IFN IFN NNP cord-005453-4057qib7 1353 6 - - HYPH cord-005453-4057qib7 1353 7 gamma gamma NN cord-005453-4057qib7 1353 8 producing produce VBG cord-005453-4057qib7 1353 9 allo allo NN cord-005453-4057qib7 1353 10 - - HYPH cord-005453-4057qib7 1353 11 T t NN cord-005453-4057qib7 1353 12 per per IN cord-005453-4057qib7 1353 13 300 300 CD cord-005453-4057qib7 1353 14 000 000 CD cord-005453-4057qib7 1353 15 donor donor NN cord-005453-4057qib7 1353 16 MNC MNC NNP cord-005453-4057qib7 1353 17 was be VBD cord-005453-4057qib7 1353 18 143,5 143,5 CD cord-005453-4057qib7 1354 1 ( ( -LRB- cord-005453-4057qib7 1354 2 2 2 CD cord-005453-4057qib7 1354 3 - - SYM cord-005453-4057qib7 1354 4 1469 1469 CD cord-005453-4057qib7 1354 5 ; ; : cord-005453-4057qib7 1354 6 EC EC NNP cord-005453-4057qib7 1354 7 : : : cord-005453-4057qib7 1354 8 SC SC NNP cord-005453-4057qib7 1354 9 ratio ratio NN cord-005453-4057qib7 1354 10 -5:1 -5:1 NN cord-005453-4057qib7 1354 11 ) ) -RRB- cord-005453-4057qib7 1354 12 and and CC cord-005453-4057qib7 1354 13 75,0 75,0 CD cord-005453-4057qib7 1354 14 ( ( -LRB- cord-005453-4057qib7 1354 15 1 1 CD cord-005453-4057qib7 1354 16 - - SYM cord-005453-4057qib7 1354 17 1440 1440 CD cord-005453-4057qib7 1354 18 ; ; : cord-005453-4057qib7 1354 19 EC EC NNP cord-005453-4057qib7 1354 20 : : : cord-005453-4057qib7 1354 21 SC SC NNP cord-005453-4057qib7 1354 22 ratio ratio NN cord-005453-4057qib7 1354 23 -10:1 -10:1 CD cord-005453-4057qib7 1354 24 ) ) -RRB- cord-005453-4057qib7 1354 25 . . . cord-005453-4057qib7 1355 1 The the DT cord-005453-4057qib7 1355 2 median median JJ cord-005453-4057qib7 1355 3 frequency frequency NN cord-005453-4057qib7 1355 4 of of IN cord-005453-4057qib7 1355 5 allo allo NN cord-005453-4057qib7 1355 6 - - HYPH cord-005453-4057qib7 1355 7 T T NNP cord-005453-4057qib7 1355 8 was be VBD cord-005453-4057qib7 1355 9 0,056 0,056 CD cord-005453-4057qib7 1355 10 % % NN cord-005453-4057qib7 1355 11 ( ( -LRB- cord-005453-4057qib7 1355 12 0,00076 0,00076 NNP cord-005453-4057qib7 1355 13 -0,538 -0,538 NNP cord-005453-4057qib7 1356 1 ; ; : cord-005453-4057qib7 1356 2 EC EC NNP cord-005453-4057qib7 1356 3 : : : cord-005453-4057qib7 1356 4 SC SC NNP cord-005453-4057qib7 1356 5 ratio ratio NN cord-005453-4057qib7 1356 6 -5:1 -5:1 NN cord-005453-4057qib7 1356 7 ) ) -RRB- cord-005453-4057qib7 1356 8 and and CC cord-005453-4057qib7 1356 9 0,019 0,019 CD cord-005453-4057qib7 1356 10 % % NN cord-005453-4057qib7 1356 11 ( ( -LRB- cord-005453-4057qib7 1356 12 0,00019 0,00019 NNP cord-005453-4057qib7 1356 13 -0,632 -0,632 NNP cord-005453-4057qib7 1356 14 ; ; : cord-005453-4057qib7 1356 15 EC EC NNP cord-005453-4057qib7 1356 16 : : : cord-005453-4057qib7 1356 17 SC SC NNP cord-005453-4057qib7 1356 18 ratio ratio NN cord-005453-4057qib7 1356 19 -10:1 -10:1 CD cord-005453-4057qib7 1356 20 ) ) -RRB- cord-005453-4057qib7 1356 21 among among IN cord-005453-4057qib7 1356 22 lymphocytes lymphocyte NNS cord-005453-4057qib7 1356 23 . . . cord-005453-4057qib7 1357 1 IL-2-producing IL-2-producing `` cord-005453-4057qib7 1357 2 allo allo NNP cord-005453-4057qib7 1357 3 - - HYPH cord-005453-4057qib7 1357 4 T T NNP cord-005453-4057qib7 1357 5 were be VBD cord-005453-4057qib7 1357 6 less less RBR cord-005453-4057qib7 1357 7 frequent frequent JJ cord-005453-4057qib7 1357 8 in in IN cord-005453-4057qib7 1357 9 donor donor NN cord-005453-4057qib7 1357 10 MNC MNC NNP cord-005453-4057qib7 1357 11 in in IN cord-005453-4057qib7 1357 12 comparison comparison NN cord-005453-4057qib7 1357 13 with with IN cord-005453-4057qib7 1357 14 IFNgamma IFNgamma NNP cord-005453-4057qib7 1357 15 - - HYPH cord-005453-4057qib7 1357 16 producing produce VBG cord-005453-4057qib7 1357 17 allo allo NN cord-005453-4057qib7 1357 18 - - HYPH cord-005453-4057qib7 1357 19 T. t. NN cord-005453-4057qib7 1358 1 The the DT cord-005453-4057qib7 1358 2 median median JJ cord-005453-4057qib7 1358 3 number number NN cord-005453-4057qib7 1358 4 per per IN cord-005453-4057qib7 1358 5 300 300 CD cord-005453-4057qib7 1358 6 000 000 CD cord-005453-4057qib7 1358 7 MNC MNC NNP cord-005453-4057qib7 1358 8 was be VBD cord-005453-4057qib7 1358 9 7,5 7,5 CD cord-005453-4057qib7 1358 10 ( ( -LRB- cord-005453-4057qib7 1358 11 0,5 0,5 CD cord-005453-4057qib7 1358 12 - - HYPH cord-005453-4057qib7 1358 13 356 356 CD cord-005453-4057qib7 1358 14 ; ; : cord-005453-4057qib7 1359 1 EC EC NNP cord-005453-4057qib7 1359 2 : : : cord-005453-4057qib7 1359 3 SC SC NNP cord-005453-4057qib7 1359 4 ratio ratio NN cord-005453-4057qib7 1359 5 -5:1 -5:1 NN cord-005453-4057qib7 1359 6 ) ) -RRB- cord-005453-4057qib7 1359 7 and and CC cord-005453-4057qib7 1359 8 6,0 6,0 CD cord-005453-4057qib7 1359 9 ( ( -LRB- cord-005453-4057qib7 1359 10 0 0 CD cord-005453-4057qib7 1359 11 - - SYM cord-005453-4057qib7 1359 12 169 169 CD cord-005453-4057qib7 1359 13 ; ; : cord-005453-4057qib7 1359 14 EC EC NNP cord-005453-4057qib7 1359 15 : : : cord-005453-4057qib7 1359 16 SC SC NNP cord-005453-4057qib7 1359 17 ratio ratio NN cord-005453-4057qib7 1359 18 -10:1 -10:1 CD cord-005453-4057qib7 1359 19 ) ) -RRB- cord-005453-4057qib7 1359 20 . . . cord-005453-4057qib7 1360 1 The the DT cord-005453-4057qib7 1360 2 median median JJ cord-005453-4057qib7 1360 3 frequency frequency NN cord-005453-4057qib7 1360 4 of of IN cord-005453-4057qib7 1360 5 IL-2-allo IL-2-allo NNP cord-005453-4057qib7 1360 6 - - HYPH cord-005453-4057qib7 1360 7 T T NNP cord-005453-4057qib7 1360 8 was be VBD cord-005453-4057qib7 1360 9 0,0028 0,0028 CD cord-005453-4057qib7 1360 10 % % NN cord-005453-4057qib7 1360 11 ( ( -LRB- cord-005453-4057qib7 1360 12 0,0002 0,0002 NNP cord-005453-4057qib7 1360 13 -0,130 -0,130 . cord-005453-4057qib7 1361 1 ; ; : cord-005453-4057qib7 1361 2 EC EC NNP cord-005453-4057qib7 1361 3 : : : cord-005453-4057qib7 1361 4 SC SC NNP cord-005453-4057qib7 1361 5 ratio ratio NN cord-005453-4057qib7 1361 6 -5:1 -5:1 NN cord-005453-4057qib7 1361 7 ) ) -RRB- cord-005453-4057qib7 1361 8 and and CC cord-005453-4057qib7 1361 9 0,0022 0,0022 CD cord-005453-4057qib7 1361 10 % % NN cord-005453-4057qib7 1361 11 ( ( -LRB- cord-005453-4057qib7 1361 12 0 0 NFP cord-005453-4057qib7 1361 13 -0,0619 -0,0619 CD cord-005453-4057qib7 1361 14 ; ; : cord-005453-4057qib7 1361 15 EC EC NNP cord-005453-4057qib7 1361 16 : : : cord-005453-4057qib7 1361 17 SC SC NNP cord-005453-4057qib7 1361 18 ratio ratio NN cord-005453-4057qib7 1361 19 -10:1 -10:1 CD cord-005453-4057qib7 1361 20 ) ) -RRB- cord-005453-4057qib7 1361 21 among among IN cord-005453-4057qib7 1361 22 lymphocytes lymphocyte NNS cord-005453-4057qib7 1361 23 . . . cord-005453-4057qib7 1362 1 The the DT cord-005453-4057qib7 1362 2 EC EC NNP cord-005453-4057qib7 1362 3 : : : cord-005453-4057qib7 1362 4 SC SC NNP cord-005453-4057qib7 1362 5 ratio ratio NN cord-005453-4057qib7 1362 6 10:1 10:1 CD cord-005453-4057qib7 1362 7 is be VBZ cord-005453-4057qib7 1362 8 enough enough JJ cord-005453-4057qib7 1362 9 for for IN cord-005453-4057qib7 1362 10 stimulation stimulation NN cord-005453-4057qib7 1362 11 of of IN cord-005453-4057qib7 1362 12 IL-2 il-2 NN cord-005453-4057qib7 1362 13 producing produce VBG cord-005453-4057qib7 1362 14 by by IN cord-005453-4057qib7 1362 15 MNC MNC NNP cord-005453-4057qib7 1362 16 in in IN cord-005453-4057qib7 1362 17 ELISPOT ELISPOT NNP cord-005453-4057qib7 1362 18 assay assay NN cord-005453-4057qib7 1362 19 , , , cord-005453-4057qib7 1362 20 but but CC cord-005453-4057qib7 1362 21 for for IN cord-005453-4057qib7 1362 22 optimal optimal JJ cord-005453-4057qib7 1362 23 stimulation stimulation NN cord-005453-4057qib7 1362 24 of of IN cord-005453-4057qib7 1362 25 IFN IFN NNP cord-005453-4057qib7 1362 26 - - HYPH cord-005453-4057qib7 1362 27 gamma gamma NN cord-005453-4057qib7 1362 28 producing produce VBG cord-005453-4057qib7 1362 29 cells cell NNS cord-005453-4057qib7 1362 30 EC EC NNP cord-005453-4057qib7 1362 31 : : : cord-005453-4057qib7 1362 32 SC SC NNP cord-005453-4057qib7 1362 33 ratio ratio NN cord-005453-4057qib7 1362 34 5:1 5:1 CD cord-005453-4057qib7 1362 35 is be VBZ cord-005453-4057qib7 1362 36 preferable preferable JJ cord-005453-4057qib7 1362 37 . . . cord-005453-4057qib7 1363 1 This this DT cord-005453-4057qib7 1363 2 suggests suggest VBZ cord-005453-4057qib7 1363 3 that that IN cord-005453-4057qib7 1363 4 allo allo NN cord-005453-4057qib7 1363 5 - - HYPH cord-005453-4057qib7 1363 6 T T NNP cord-005453-4057qib7 1363 7 are be VBP cord-005453-4057qib7 1363 8 predominantly predominantly RB cord-005453-4057qib7 1363 9 IFN IFN NNP cord-005453-4057qib7 1363 10 - - HYPH cord-005453-4057qib7 1363 11 gamma gamma NN cord-005453-4057qib7 1363 12 producing produce VBG cord-005453-4057qib7 1363 13 cells cell NNS cord-005453-4057qib7 1363 14 . . . cord-005453-4057qib7 1364 1 Alloreactive alloreactive JJ cord-005453-4057qib7 1364 2 proliferating proliferate VBG cord-005453-4057qib7 1364 3 T t NN cord-005453-4057qib7 1364 4 - - HYPH cord-005453-4057qib7 1364 5 clones clone NNS cord-005453-4057qib7 1364 6 were be VBD cord-005453-4057qib7 1364 7 detected detect VBN cord-005453-4057qib7 1364 8 in in IN cord-005453-4057qib7 1364 9 MLC MLC NNP cord-005453-4057qib7 1364 10 in in IN cord-005453-4057qib7 1364 11 10 10 CD cord-005453-4057qib7 1364 12 of of IN cord-005453-4057qib7 1364 13 14 14 CD cord-005453-4057qib7 1364 14 donor donor NN cord-005453-4057qib7 1364 15 - - HYPH cord-005453-4057qib7 1364 16 recipient recipient NN cord-005453-4057qib7 1364 17 pairs pair NNS cord-005453-4057qib7 1364 18 on on IN cord-005453-4057qib7 1364 19 5 5 CD cord-005453-4057qib7 1364 20 day day NN cord-005453-4057qib7 1364 21 of of IN cord-005453-4057qib7 1364 22 cocultivation cocultivation NN cord-005453-4057qib7 1364 23 . . . cord-005453-4057qib7 1365 1 Median median JJ cord-005453-4057qib7 1365 2 percentage percentage NN cord-005453-4057qib7 1365 3 of of IN cord-005453-4057qib7 1365 4 proliferating proliferate VBG cord-005453-4057qib7 1365 5 T t NN cord-005453-4057qib7 1365 6 - - HYPH cord-005453-4057qib7 1365 7 clones clone NNS cord-005453-4057qib7 1365 8 were be VBD cord-005453-4057qib7 1365 9 9,5 9,5 CD cord-005453-4057qib7 1365 10 % % NN cord-005453-4057qib7 1365 11 ( ( -LRB- cord-005453-4057qib7 1365 12 2,1 2,1 CD cord-005453-4057qib7 1365 13 -32,5 -32,5 UH cord-005453-4057qib7 1365 14 ; ; : cord-005453-4057qib7 1365 15 EC EC NNP cord-005453-4057qib7 1365 16 : : : cord-005453-4057qib7 1365 17 SC SC NNP cord-005453-4057qib7 1365 18 ratio ratio NN cord-005453-4057qib7 1365 19 -5:1 -5:1 NN cord-005453-4057qib7 1365 20 ) ) -RRB- cord-005453-4057qib7 1365 21 and and CC cord-005453-4057qib7 1365 22 7,6 7,6 CD cord-005453-4057qib7 1365 23 % % NN cord-005453-4057qib7 1365 24 ( ( -LRB- cord-005453-4057qib7 1365 25 3,0 3,0 NNP cord-005453-4057qib7 1365 26 -24,1 -24,1 XX cord-005453-4057qib7 1365 27 ; ; : cord-005453-4057qib7 1365 28 EC EC NNP cord-005453-4057qib7 1365 29 : : : cord-005453-4057qib7 1365 30 SC SC NNP cord-005453-4057qib7 1365 31 ratio ratio NN cord-005453-4057qib7 1365 32 -10:1 -10:1 CD cord-005453-4057qib7 1365 33 ) ) -RRB- cord-005453-4057qib7 1365 34 among among IN cord-005453-4057qib7 1365 35 lymphocytes lymphocyte NNS cord-005453-4057qib7 1365 36 . . . cord-005453-4057qib7 1366 1 However however RB cord-005453-4057qib7 1366 2 , , , cord-005453-4057qib7 1366 3 MLC MLC NNP cord-005453-4057qib7 1366 4 assay assay NN cord-005453-4057qib7 1366 5 only only RB cord-005453-4057qib7 1366 6 permit permit VBP cord-005453-4057qib7 1366 7 a a DT cord-005453-4057qib7 1366 8 qualitative qualitative JJ cord-005453-4057qib7 1366 9 analysis analysis NN cord-005453-4057qib7 1366 10 that that WDT cord-005453-4057qib7 1366 11 confirmed confirm VBD cord-005453-4057qib7 1366 12 the the DT cord-005453-4057qib7 1366 13 presence presence NN cord-005453-4057qib7 1366 14 of of IN cord-005453-4057qib7 1366 15 alloreactive alloreactive NNP cord-005453-4057qib7 1366 16 T T NNP cord-005453-4057qib7 1366 17 - - HYPH cord-005453-4057qib7 1366 18 clones clone NNS cord-005453-4057qib7 1366 19 , , , cord-005453-4057qib7 1366 20 giving give VBG cord-005453-4057qib7 1366 21 no no DT cord-005453-4057qib7 1366 22 information information NN cord-005453-4057qib7 1366 23 on on IN cord-005453-4057qib7 1366 24 their -PRON- PRP$ cord-005453-4057qib7 1366 25 frequency frequency NN cord-005453-4057qib7 1366 26 within within IN cord-005453-4057qib7 1366 27 the the DT cord-005453-4057qib7 1366 28 culture culture NN cord-005453-4057qib7 1366 29 . . . cord-005453-4057qib7 1367 1 Results result NNS cord-005453-4057qib7 1367 2 of of IN cord-005453-4057qib7 1367 3 ELISPOT ELISPOT NNP cord-005453-4057qib7 1367 4 and and CC cord-005453-4057qib7 1367 5 MCL MCL NNP cord-005453-4057qib7 1367 6 assay assay NN cord-005453-4057qib7 1367 7 directly directly RB cord-005453-4057qib7 1367 8 correlated correlate VBN cord-005453-4057qib7 1367 9 . . . cord-005453-4057qib7 1368 1 Conclusions conclusion NNS cord-005453-4057qib7 1368 2 : : : cord-005453-4057qib7 1369 1 Allo Allo NNP cord-005453-4057qib7 1369 2 - - HYPH cord-005453-4057qib7 1369 3 T T NNP cord-005453-4057qib7 1369 4 were be VBD cord-005453-4057qib7 1369 5 detected detect VBN cord-005453-4057qib7 1369 6 in in IN cord-005453-4057qib7 1369 7 100,0 100,0 CD cord-005453-4057qib7 1369 8 % % NN cord-005453-4057qib7 1369 9 of of IN cord-005453-4057qib7 1369 10 assayed assay VBN cord-005453-4057qib7 1369 11 haploidentical haploidentical JJ cord-005453-4057qib7 1369 12 donor donor NN cord-005453-4057qib7 1369 13 - - HYPH cord-005453-4057qib7 1369 14 recipient recipient NN cord-005453-4057qib7 1369 15 pairs pair NNS cord-005453-4057qib7 1369 16 by by IN cord-005453-4057qib7 1369 17 ELISPOT ELISPOT NNP cord-005453-4057qib7 1369 18 and and CC cord-005453-4057qib7 1369 19 only only RB cord-005453-4057qib7 1369 20 in in IN cord-005453-4057qib7 1369 21 71,4 71,4 CD cord-005453-4057qib7 1369 22 % % NN cord-005453-4057qib7 1369 23 by by IN cord-005453-4057qib7 1369 24 MLC MLC NNP cord-005453-4057qib7 1369 25 . . . cord-005453-4057qib7 1370 1 This this DT cord-005453-4057qib7 1370 2 difference difference NN cord-005453-4057qib7 1370 3 in in IN cord-005453-4057qib7 1370 4 detection detection NN cord-005453-4057qib7 1370 5 is be VBZ cord-005453-4057qib7 1370 6 due due JJ cord-005453-4057qib7 1370 7 to to IN cord-005453-4057qib7 1370 8 the the DT cord-005453-4057qib7 1370 9 fact fact NN cord-005453-4057qib7 1370 10 that that IN cord-005453-4057qib7 1370 11 ELISPOT ELISPOT NNP cord-005453-4057qib7 1370 12 allows allow VBZ cord-005453-4057qib7 1370 13 to to TO cord-005453-4057qib7 1370 14 detect detect VB cord-005453-4057qib7 1370 15 single single JJ cord-005453-4057qib7 1370 16 cytokine cytokine NN cord-005453-4057qib7 1370 17 secreting secrete VBG cord-005453-4057qib7 1370 18 cell cell NN cord-005453-4057qib7 1370 19 whereas whereas IN cord-005453-4057qib7 1370 20 MLC MLC NNP cord-005453-4057qib7 1370 21 can can MD cord-005453-4057qib7 1370 22 reveal reveal VB cord-005453-4057qib7 1370 23 proliferating proliferate VBG cord-005453-4057qib7 1370 24 аllo аllo NN cord-005453-4057qib7 1370 25 - - HYPH cord-005453-4057qib7 1370 26 T T NNP cord-005453-4057qib7 1370 27 clones clone NNS cord-005453-4057qib7 1370 28 . . . cord-005453-4057qib7 1371 1 The the DT cord-005453-4057qib7 1371 2 analysis analysis NN cord-005453-4057qib7 1371 3 of of IN cord-005453-4057qib7 1371 4 allo allo NN cord-005453-4057qib7 1371 5 - - HYPH cord-005453-4057qib7 1371 6 T T NNP cord-005453-4057qib7 1371 7 in in IN cord-005453-4057qib7 1371 8 haploidentical haploidentical JJ cord-005453-4057qib7 1371 9 donor donor NN cord-005453-4057qib7 1371 10 - - HYPH cord-005453-4057qib7 1371 11 recipient recipient NN cord-005453-4057qib7 1371 12 pairs pair NNS cord-005453-4057qib7 1371 13 may may MD cord-005453-4057qib7 1371 14 provide provide VB cord-005453-4057qib7 1371 15 rationale rationale NN cord-005453-4057qib7 1371 16 to to TO cord-005453-4057qib7 1371 17 manipulate manipulate VB cord-005453-4057qib7 1371 18 the the DT cord-005453-4057qib7 1371 19 allo allo NN cord-005453-4057qib7 1371 20 - - HYPH cord-005453-4057qib7 1371 21 immune immune JJ cord-005453-4057qib7 1371 22 response response NN cord-005453-4057qib7 1371 23 and and CC cord-005453-4057qib7 1371 24 to to TO cord-005453-4057qib7 1371 25 exploit exploit VB cord-005453-4057qib7 1371 26 the the DT cord-005453-4057qib7 1371 27 powerful powerful JJ cord-005453-4057qib7 1371 28 ability ability NN cord-005453-4057qib7 1371 29 of of IN cord-005453-4057qib7 1371 30 allo allo NN cord-005453-4057qib7 1371 31 - - HYPH cord-005453-4057qib7 1371 32 T t NN cord-005453-4057qib7 1371 33 to to TO cord-005453-4057qib7 1371 34 control control VB cord-005453-4057qib7 1371 35 hematologic hematologic JJ cord-005453-4057qib7 1371 36 malignancies malignancy NNS cord-005453-4057qib7 1371 37 . . . cord-005453-4057qib7 1372 1 Disclosure disclosure NN cord-005453-4057qib7 1372 2 : : : cord-005453-4057qib7 1372 3 Nothing nothing NN cord-005453-4057qib7 1372 4 to to TO cord-005453-4057qib7 1372 5 declare declare VB cord-005453-4057qib7 1372 6 Allogeneic Allogeneic NNP cord-005453-4057qib7 1372 7 mesenchymal mesenchymal JJ cord-005453-4057qib7 1372 8 stromal stromal JJ cord-005453-4057qib7 1372 9 cell cell NN cord-005453-4057qib7 1372 10 as as IN cord-005453-4057qib7 1372 11 rescue rescue NN cord-005453-4057qib7 1372 12 therapy therapy NN cord-005453-4057qib7 1372 13 in in IN cord-005453-4057qib7 1372 14 an an DT cord-005453-4057qib7 1372 15 infant infant NN cord-005453-4057qib7 1372 16 with with IN cord-005453-4057qib7 1372 17 life life NN cord-005453-4057qib7 1372 18 - - HYPH cord-005453-4057qib7 1372 19 threatening threaten VBG cord-005453-4057qib7 1372 20 respiratory respiratory JJ cord-005453-4057qib7 1372 21 syndrome syndrome NN cord-005453-4057qib7 1372 22 due due IN cord-005453-4057qib7 1372 23 to to IN cord-005453-4057qib7 1372 24 a a DT cord-005453-4057qib7 1372 25 filamin filamin NN cord-005453-4057qib7 1373 1 a a DT cord-005453-4057qib7 1373 2 mutation mutation NN cord-005453-4057qib7 1373 3 Background background NN cord-005453-4057qib7 1373 4 : : : cord-005453-4057qib7 1374 1 Cell cell NN cord-005453-4057qib7 1374 2 - - HYPH cord-005453-4057qib7 1374 3 based base VBN cord-005453-4057qib7 1374 4 therapy therapy NN cord-005453-4057qib7 1374 5 has have VBZ cord-005453-4057qib7 1374 6 gained gain VBN cord-005453-4057qib7 1374 7 attention attention NN cord-005453-4057qib7 1374 8 in in IN cord-005453-4057qib7 1374 9 the the DT cord-005453-4057qib7 1374 10 respiratory respiratory JJ cord-005453-4057qib7 1374 11 system system NN cord-005453-4057qib7 1374 12 diseases disease NNS cord-005453-4057qib7 1374 13 and and CC cord-005453-4057qib7 1374 14 encouraging encouraging JJ cord-005453-4057qib7 1374 15 results result NNS cord-005453-4057qib7 1374 16 are be VBP cord-005453-4057qib7 1374 17 reported report VBN cord-005453-4057qib7 1374 18 following follow VBG cord-005453-4057qib7 1374 19 mesenchymal mesenchymal JJ cord-005453-4057qib7 1374 20 stromal stromal NN cord-005453-4057qib7 1374 21 cells cell NNS cord-005453-4057qib7 1374 22 ( ( -LRB- cord-005453-4057qib7 1374 23 MSCs MSCs NNP cord-005453-4057qib7 1374 24 ) ) -RRB- cord-005453-4057qib7 1374 25 administration administration NN cord-005453-4057qib7 1374 26 . . . cord-005453-4057qib7 1375 1 Due due IN cord-005453-4057qib7 1375 2 to to IN cord-005453-4057qib7 1375 3 their -PRON- PRP$ cord-005453-4057qib7 1375 4 capacity capacity NN cord-005453-4057qib7 1375 5 to to TO cord-005453-4057qib7 1375 6 produce produce VB cord-005453-4057qib7 1375 7 and and CC cord-005453-4057qib7 1375 8 secrete secrete VB cord-005453-4057qib7 1375 9 a a DT cord-005453-4057qib7 1375 10 variety variety NN cord-005453-4057qib7 1375 11 of of IN cord-005453-4057qib7 1375 12 paracrine paracrine JJ cord-005453-4057qib7 1375 13 factors factor NNS cord-005453-4057qib7 1375 14 and and CC cord-005453-4057qib7 1375 15 bioactive bioactive JJ cord-005453-4057qib7 1375 16 macromolecules macromolecule NNS cord-005453-4057qib7 1375 17 , , , cord-005453-4057qib7 1375 18 MSCs msc NNS cord-005453-4057qib7 1375 19 became become VBD cord-005453-4057qib7 1375 20 a a DT cord-005453-4057qib7 1375 21 key key JJ cord-005453-4057qib7 1375 22 player player NN cord-005453-4057qib7 1375 23 in in IN cord-005453-4057qib7 1375 24 lung lung NN cord-005453-4057qib7 1375 25 tissue tissue NN cord-005453-4057qib7 1375 26 injuries injury NNS cord-005453-4057qib7 1375 27 and and CC cord-005453-4057qib7 1375 28 function function NN cord-005453-4057qib7 1375 29 , , , cord-005453-4057qib7 1375 30 reducing reduce VBG cord-005453-4057qib7 1375 31 fibrosis fibrosis NN cord-005453-4057qib7 1375 32 , , , cord-005453-4057qib7 1375 33 promoting promote VBG cord-005453-4057qib7 1375 34 the the DT cord-005453-4057qib7 1375 35 normal normal JJ cord-005453-4057qib7 1375 36 development development NN cord-005453-4057qib7 1375 37 of of IN cord-005453-4057qib7 1375 38 alveoli alveolus NNS cord-005453-4057qib7 1375 39 and and CC cord-005453-4057qib7 1375 40 pulmonary pulmonary JJ cord-005453-4057qib7 1375 41 vessels vessel NNS cord-005453-4057qib7 1375 42 . . . cord-005453-4057qib7 1376 1 For for IN cord-005453-4057qib7 1376 2 the the DT cord-005453-4057qib7 1376 3 first first JJ cord-005453-4057qib7 1376 4 time time NN cord-005453-4057qib7 1376 5 we -PRON- PRP cord-005453-4057qib7 1376 6 used use VBD cord-005453-4057qib7 1376 7 the the DT cord-005453-4057qib7 1376 8 MSC MSC NNP cord-005453-4057qib7 1376 9 infusions infusion NNS cord-005453-4057qib7 1376 10 as as IN cord-005453-4057qib7 1376 11 rescue rescue NN cord-005453-4057qib7 1376 12 therapy therapy NN cord-005453-4057qib7 1376 13 in in IN cord-005453-4057qib7 1376 14 a a DT cord-005453-4057qib7 1376 15 pediatric pediatric JJ cord-005453-4057qib7 1376 16 patient patient NN cord-005453-4057qib7 1376 17 with with IN cord-005453-4057qib7 1376 18 FLNA FLNA NNP cord-005453-4057qib7 1376 19 gene gene NN cord-005453-4057qib7 1376 20 mutation mutation NN cord-005453-4057qib7 1376 21 and and CC cord-005453-4057qib7 1376 22 life life NN cord-005453-4057qib7 1376 23 - - HYPH cord-005453-4057qib7 1376 24 threatening threaten VBG cord-005453-4057qib7 1376 25 respiratory respiratory JJ cord-005453-4057qib7 1376 26 syndrome syndrome NN cord-005453-4057qib7 1376 27 . . . cord-005453-4057qib7 1377 1 Methods method NNS cord-005453-4057qib7 1377 2 : : : cord-005453-4057qib7 1377 3 A a DT cord-005453-4057qib7 1377 4 child child NN cord-005453-4057qib7 1377 5 with with IN cord-005453-4057qib7 1377 6 a a DT cord-005453-4057qib7 1377 7 new new JJ cord-005453-4057qib7 1377 8 pathogenic pathogenic JJ cord-005453-4057qib7 1377 9 variant variant NN cord-005453-4057qib7 1377 10 of of IN cord-005453-4057qib7 1377 11 the the DT cord-005453-4057qib7 1377 12 FLNA FLNA NNP cord-005453-4057qib7 1377 13 gene gene NN cord-005453-4057qib7 1377 14 c.7391_7403del c.7391_7403del NN cord-005453-4057qib7 1377 15 ; ; , cord-005453-4057qib7 1377 16 ( ( -LRB- cord-005453-4057qib7 1377 17 p. p. NN cord-005453-4057qib7 1378 1 Val2464AlafsTer5 Val2464AlafsTer5 NNP cord-005453-4057qib7 1378 2 ) ) -RRB- cord-005453-4057qib7 1378 3 at at IN cord-005453-4057qib7 1378 4 the the DT cord-005453-4057qib7 1378 5 age age NN cord-005453-4057qib7 1378 6 of of IN cord-005453-4057qib7 1378 7 18 18 CD cord-005453-4057qib7 1378 8 months month NNS cord-005453-4057qib7 1378 9 , , , cord-005453-4057qib7 1378 10 due due IN cord-005453-4057qib7 1378 11 to to IN cord-005453-4057qib7 1378 12 the the DT cord-005453-4057qib7 1378 13 serious serious JJ cord-005453-4057qib7 1378 14 and and CC cord-005453-4057qib7 1378 15 irreversible irreversible JJ cord-005453-4057qib7 1378 16 chronic chronic JJ cord-005453-4057qib7 1378 17 respiratory respiratory JJ cord-005453-4057qib7 1378 18 failure failure NN cord-005453-4057qib7 1378 19 and and CC cord-005453-4057qib7 1378 20 dismal dismal JJ cord-005453-4057qib7 1378 21 prognosis prognosis NN cord-005453-4057qib7 1378 22 , , , cord-005453-4057qib7 1378 23 was be VBD cord-005453-4057qib7 1378 24 treated treat VBN cord-005453-4057qib7 1378 25 with with IN cord-005453-4057qib7 1378 26 4 4 CD cord-005453-4057qib7 1378 27 intravenous intravenous JJ cord-005453-4057qib7 1378 28 infusions infusion NNS cord-005453-4057qib7 1378 29 of of IN cord-005453-4057qib7 1378 30 allogeneic allogeneic NN cord-005453-4057qib7 1378 31 bone bone NN cord-005453-4057qib7 1378 32 marrow marrow NN cord-005453-4057qib7 1379 1 ( ( -LRB- cord-005453-4057qib7 1379 2 BM)-MSCs BM)-MSCs NNP cord-005453-4057qib7 1379 3 at at IN cord-005453-4057qib7 1379 4 the the DT cord-005453-4057qib7 1379 5 dose dose NN cord-005453-4057qib7 1379 6 of of IN cord-005453-4057qib7 1379 7 1×10 1×10 CD cord-005453-4057qib7 1379 8 6 6 CD cord-005453-4057qib7 1379 9 MSCs msc NNS cord-005453-4057qib7 1379 10 / / SYM cord-005453-4057qib7 1379 11 kg kg NN cord-005453-4057qib7 1379 12 body body NN cord-005453-4057qib7 1379 13 weight weight NN cord-005453-4057qib7 1379 14 . . . cord-005453-4057qib7 1380 1 BM BM NNP cord-005453-4057qib7 1380 2 - - HYPH cord-005453-4057qib7 1380 3 MSCs msc NNS cord-005453-4057qib7 1380 4 were be VBD cord-005453-4057qib7 1380 5 produced produce VBN cord-005453-4057qib7 1380 6 at at IN cord-005453-4057qib7 1380 7 " " `` cord-005453-4057qib7 1380 8 Cell Cell NNP cord-005453-4057qib7 1380 9 Factory Factory NNP cord-005453-4057qib7 1380 10 " " '' cord-005453-4057qib7 1380 11 , , , cord-005453-4057qib7 1380 12 Fondazione Fondazione NNP cord-005453-4057qib7 1380 13 IRCCS IRCCS NNP cord-005453-4057qib7 1380 14 Policlinico Policlinico NNP cord-005453-4057qib7 1380 15 S. S. NNP cord-005453-4057qib7 1380 16 Matteo Matteo NNP cord-005453-4057qib7 1380 17 , , , cord-005453-4057qib7 1380 18 Pavia Pavia NNP cord-005453-4057qib7 1380 19 , , , cord-005453-4057qib7 1380 20 isolated isolated JJ cord-005453-4057qib7 1380 21 and and CC cord-005453-4057qib7 1380 22 expanded expand VBN cord-005453-4057qib7 1380 23 ex ex FW cord-005453-4057qib7 1380 24 vivo vivo NN cord-005453-4057qib7 1380 25 from from IN cord-005453-4057qib7 1380 26 healthy healthy JJ cord-005453-4057qib7 1380 27 donor donor NN cord-005453-4057qib7 1380 28 BM bm NN cord-005453-4057qib7 1380 29 , , , cord-005453-4057qib7 1380 30 following follow VBG cord-005453-4057qib7 1380 31 a a DT cord-005453-4057qib7 1380 32 previously previously RB cord-005453-4057qib7 1380 33 reported report VBN cord-005453-4057qib7 1380 34 protocol protocol NN cord-005453-4057qib7 1380 35 . . . cord-005453-4057qib7 1381 1 Premedication Premedication NNP cord-005453-4057qib7 1381 2 with with IN cord-005453-4057qib7 1381 3 antistaminic antistaminic NNP cord-005453-4057qib7 1381 4 drug drug NN cord-005453-4057qib7 1381 5 , , , cord-005453-4057qib7 1381 6 30 30 CD cord-005453-4057qib7 1381 7 min min NN cord-005453-4057qib7 1381 8 before before IN cord-005453-4057qib7 1381 9 every every DT cord-005453-4057qib7 1381 10 infusion infusion NN cord-005453-4057qib7 1381 11 to to TO cord-005453-4057qib7 1381 12 avoid avoid VB cord-005453-4057qib7 1381 13 any any DT cord-005453-4057qib7 1381 14 potential potential JJ cord-005453-4057qib7 1381 15 reaction reaction NN cord-005453-4057qib7 1381 16 was be VBD cord-005453-4057qib7 1381 17 performed perform VBN cord-005453-4057qib7 1381 18 . . . cord-005453-4057qib7 1382 1 The the DT cord-005453-4057qib7 1382 2 evolution evolution NN cord-005453-4057qib7 1382 3 of of IN cord-005453-4057qib7 1382 4 the the DT cord-005453-4057qib7 1382 5 respiratory respiratory JJ cord-005453-4057qib7 1382 6 condition condition NN cord-005453-4057qib7 1382 7 was be VBD cord-005453-4057qib7 1382 8 detected detect VBN cord-005453-4057qib7 1382 9 . . . cord-005453-4057qib7 1383 1 Peripheral peripheral JJ cord-005453-4057qib7 1383 2 blood blood NN cord-005453-4057qib7 1383 3 were be VBD cord-005453-4057qib7 1383 4 collected collect VBN cord-005453-4057qib7 1383 5 before before IN cord-005453-4057qib7 1383 6 each each DT cord-005453-4057qib7 1383 7 MSC MSC NNP cord-005453-4057qib7 1383 8 treatment treatment NN cord-005453-4057qib7 1383 9 for for IN cord-005453-4057qib7 1383 10 Treg Treg NNP cord-005453-4057qib7 1383 11 and and CC cord-005453-4057qib7 1383 12 Th17 Th17 NNP cord-005453-4057qib7 1383 13 monitoring monitoring NN cord-005453-4057qib7 1383 14 . . . cord-005453-4057qib7 1384 1 Treg Treg NNP cord-005453-4057qib7 1384 2 , , , cord-005453-4057qib7 1384 3 defined define VBN cord-005453-4057qib7 1384 4 as as IN cord-005453-4057qib7 1384 5 CD4 CD4 NNP cord-005453-4057qib7 1384 6 + + CC cord-005453-4057qib7 1385 1 CD127neg cd127neg CD cord-005453-4057qib7 1385 2 CD25 CD25 NNP cord-005453-4057qib7 1385 3 + + CC cord-005453-4057qib7 1385 4 cells cell NNS cord-005453-4057qib7 1385 5 expressing express VBG cord-005453-4057qib7 1385 6 the the DT cord-005453-4057qib7 1385 7 forkhead forkhead NNP cord-005453-4057qib7 1385 8 box box NN cord-005453-4057qib7 1385 9 P3 P3 NNP cord-005453-4057qib7 1385 10 ( ( -LRB- cord-005453-4057qib7 1385 11 FoxP3 FoxP3 NNP cord-005453-4057qib7 1385 12 ) ) -RRB- cord-005453-4057qib7 1385 13 transcription transcription NN cord-005453-4057qib7 1385 14 factor factor NN cord-005453-4057qib7 1385 15 , , , cord-005453-4057qib7 1385 16 and and CC cord-005453-4057qib7 1386 1 Th17 Th17 NNP cord-005453-4057qib7 1386 2 , , , cord-005453-4057qib7 1386 3 defined define VBN cord-005453-4057qib7 1386 4 as as IN cord-005453-4057qib7 1386 5 CD4 CD4 NNP cord-005453-4057qib7 1386 6 + + CC cord-005453-4057qib7 1386 7 cells cell NNS cord-005453-4057qib7 1386 8 expressing express VBG cord-005453-4057qib7 1386 9 intracellular intracellular JJ cord-005453-4057qib7 1386 10 IL-17 IL-17 NNP cord-005453-4057qib7 1386 11 , , , cord-005453-4057qib7 1386 12 evaluation evaluation NN cord-005453-4057qib7 1386 13 was be VBD cord-005453-4057qib7 1386 14 performed perform VBN cord-005453-4057qib7 1386 15 by by IN cord-005453-4057qib7 1386 16 flow flow NN cord-005453-4057qib7 1386 17 cytometry cytometry NN cord-005453-4057qib7 1386 18 ( ( -LRB- cord-005453-4057qib7 1386 19 FACSCanto FACSCanto NNS cord-005453-4057qib7 1386 20 ; ; : cord-005453-4057qib7 1386 21 BD BD NNP cord-005453-4057qib7 1386 22 Biosciences Biosciences NNP cord-005453-4057qib7 1386 23 , , , cord-005453-4057qib7 1386 24 San San NNP cord-005453-4057qib7 1386 25 Diego Diego NNP cord-005453-4057qib7 1386 26 , , , cord-005453-4057qib7 1386 27 CA CA NNP cord-005453-4057qib7 1386 28 ) ) -RRB- cord-005453-4057qib7 1386 29 as as IN cord-005453-4057qib7 1386 30 previously previously RB cord-005453-4057qib7 1386 31 reported report VBN cord-005453-4057qib7 1386 32 , , , cord-005453-4057qib7 1386 33 following follow VBG cord-005453-4057qib7 1386 34 standard standard JJ cord-005453-4057qib7 1386 35 procedures procedure NNS cord-005453-4057qib7 1386 36 . . . cord-005453-4057qib7 1387 1 Results result NNS cord-005453-4057qib7 1387 2 : : : cord-005453-4057qib7 1388 1 No no DT cord-005453-4057qib7 1388 2 acute acute JJ cord-005453-4057qib7 1388 3 adverse adverse JJ cord-005453-4057qib7 1388 4 events event NNS cord-005453-4057qib7 1388 5 related relate VBN cord-005453-4057qib7 1388 6 to to IN cord-005453-4057qib7 1388 7 MSCs mscs JJ cord-005453-4057qib7 1388 8 infusion infusion NN cord-005453-4057qib7 1388 9 was be VBD cord-005453-4057qib7 1388 10 recorded record VBN cord-005453-4057qib7 1388 11 . . . cord-005453-4057qib7 1389 1 During during IN cord-005453-4057qib7 1389 2 follow follow NN cord-005453-4057qib7 1389 3 - - HYPH cord-005453-4057qib7 1389 4 up up NN cord-005453-4057qib7 1389 5 , , , cord-005453-4057qib7 1389 6 patient patient NN cord-005453-4057qib7 1389 7 maintained maintain VBD cord-005453-4057qib7 1389 8 a a DT cord-005453-4057qib7 1389 9 good good JJ cord-005453-4057qib7 1389 10 general general JJ cord-005453-4057qib7 1389 11 condition condition NN cord-005453-4057qib7 1389 12 and and CC cord-005453-4057qib7 1389 13 showed show VBD cord-005453-4057qib7 1389 14 a a DT cord-005453-4057qib7 1389 15 regular regular JJ cord-005453-4057qib7 1389 16 growth growth NN cord-005453-4057qib7 1389 17 . . . cord-005453-4057qib7 1390 1 No no DT cord-005453-4057qib7 1390 2 systemic systemic JJ cord-005453-4057qib7 1390 3 or or CC cord-005453-4057qib7 1390 4 respiratory respiratory JJ cord-005453-4057qib7 1390 5 infections infection NNS cord-005453-4057qib7 1390 6 occurred occur VBD cord-005453-4057qib7 1390 7 . . . cord-005453-4057qib7 1391 1 After after IN cord-005453-4057qib7 1391 2 the the DT cord-005453-4057qib7 1391 3 second second JJ cord-005453-4057qib7 1391 4 infusion infusion NN cord-005453-4057qib7 1391 5 , , , cord-005453-4057qib7 1391 6 the the DT cord-005453-4057qib7 1391 7 child child NN cord-005453-4057qib7 1391 8 experienced experience VBD cord-005453-4057qib7 1391 9 a a DT cord-005453-4057qib7 1391 10 progressive progressive JJ cord-005453-4057qib7 1391 11 improvement improvement NN cord-005453-4057qib7 1391 12 of of IN cord-005453-4057qib7 1391 13 his -PRON- PRP$ cord-005453-4057qib7 1391 14 clinical clinical JJ cord-005453-4057qib7 1391 15 respiratory respiratory JJ cord-005453-4057qib7 1391 16 condition condition NN cord-005453-4057qib7 1391 17 , , , cord-005453-4057qib7 1391 18 with with IN cord-005453-4057qib7 1391 19 a a DT cord-005453-4057qib7 1391 20 good good JJ cord-005453-4057qib7 1391 21 adaptation adaptation NN cord-005453-4057qib7 1391 22 to to IN cord-005453-4057qib7 1391 23 mechanical mechanical JJ cord-005453-4057qib7 1391 24 ventilation ventilation NN cord-005453-4057qib7 1391 25 , , , cord-005453-4057qib7 1391 26 in in IN cord-005453-4057qib7 1391 27 the the DT cord-005453-4057qib7 1391 28 absence absence NN cord-005453-4057qib7 1391 29 of of IN cord-005453-4057qib7 1391 30 episodes episode NNS cord-005453-4057qib7 1391 31 of of IN cord-005453-4057qib7 1391 32 respiratory respiratory JJ cord-005453-4057qib7 1391 33 exacerbations exacerbation NNS cord-005453-4057qib7 1391 34 . . . cord-005453-4057qib7 1392 1 The the DT cord-005453-4057qib7 1392 2 baby baby NN cord-005453-4057qib7 1392 3 maintains maintain VBZ cord-005453-4057qib7 1392 4 adequate adequate JJ cord-005453-4057qib7 1392 5 volumes volume NNS cord-005453-4057qib7 1392 6 of of IN cord-005453-4057qib7 1392 7 exchange exchange NN cord-005453-4057qib7 1392 8 with with IN cord-005453-4057qib7 1392 9 substantial substantial JJ cord-005453-4057qib7 1392 10 reduction reduction NN cord-005453-4057qib7 1392 11 of of IN cord-005453-4057qib7 1392 12 the the DT cord-005453-4057qib7 1392 13 inspiratory inspiratory JJ cord-005453-4057qib7 1392 14 support support NN cord-005453-4057qib7 1392 15 . . . cord-005453-4057qib7 1393 1 A a DT cord-005453-4057qib7 1393 2 reduction reduction NN cord-005453-4057qib7 1393 3 of of IN cord-005453-4057qib7 1393 4 trigger trigger NN cord-005453-4057qib7 1393 5 sensitivity sensitivity NN cord-005453-4057qib7 1393 6 was be VBD cord-005453-4057qib7 1393 7 also also RB cord-005453-4057qib7 1393 8 obtained obtain VBN cord-005453-4057qib7 1393 9 . . . cord-005453-4057qib7 1394 1 Thorax Thorax NNP cord-005453-4057qib7 1394 2 CT CT NNP cord-005453-4057qib7 1394 3 scan scan NN cord-005453-4057qib7 1394 4 showed show VBD cord-005453-4057qib7 1394 5 a a DT cord-005453-4057qib7 1394 6 recovery recovery NN cord-005453-4057qib7 1394 7 of of IN cord-005453-4057qib7 1394 8 the the DT cord-005453-4057qib7 1394 9 basal basal NN cord-005453-4057qib7 1394 10 parenchyma parenchyma NN cord-005453-4057qib7 1394 11 bilaterally bilaterally RB cord-005453-4057qib7 1394 12 and and CC cord-005453-4057qib7 1394 13 the the DT cord-005453-4057qib7 1394 14 improvement improvement NN cord-005453-4057qib7 1394 15 of of IN cord-005453-4057qib7 1394 16 the the DT cord-005453-4057qib7 1394 17 anatomical anatomical JJ cord-005453-4057qib7 1394 18 - - HYPH cord-005453-4057qib7 1394 19 functional functional JJ cord-005453-4057qib7 1394 20 alignment alignment NN cord-005453-4057qib7 1394 21 and and CC cord-005453-4057qib7 1394 22 aerial aerial JJ cord-005453-4057qib7 1394 23 penetration penetration NN cord-005453-4057qib7 1394 24 . . . cord-005453-4057qib7 1395 1 After after IN cord-005453-4057qib7 1395 2 the the DT cord-005453-4057qib7 1395 3 first first JJ cord-005453-4057qib7 1395 4 MSC MSC NNP cord-005453-4057qib7 1395 5 administration administration NN cord-005453-4057qib7 1395 6 , , , cord-005453-4057qib7 1395 7 an an DT cord-005453-4057qib7 1395 8 enrichment enrichment NN cord-005453-4057qib7 1395 9 of of IN cord-005453-4057qib7 1395 10 Treg Treg NNP cord-005453-4057qib7 1395 11 and and CC cord-005453-4057qib7 1395 12 Th17 th17 CD cord-005453-4057qib7 1395 13 percentage percentage NN cord-005453-4057qib7 1395 14 in in IN cord-005453-4057qib7 1395 15 peripheral peripheral JJ cord-005453-4057qib7 1395 16 blood blood NN cord-005453-4057qib7 1395 17 , , , cord-005453-4057qib7 1395 18 was be VBD cord-005453-4057qib7 1395 19 observed observe VBN cord-005453-4057qib7 1395 20 . . . cord-005453-4057qib7 1396 1 While while IN cord-005453-4057qib7 1396 2 , , , cord-005453-4057qib7 1396 3 after after IN cord-005453-4057qib7 1396 4 the the DT cord-005453-4057qib7 1396 5 second second JJ cord-005453-4057qib7 1396 6 MSC MSC NNP cord-005453-4057qib7 1396 7 infusion infusion NN cord-005453-4057qib7 1396 8 a a DT cord-005453-4057qib7 1396 9 significant significant JJ cord-005453-4057qib7 1396 10 increase increase NN cord-005453-4057qib7 1396 11 in in IN cord-005453-4057qib7 1397 1 Treg Treg NNP cord-005453-4057qib7 1397 2 / / SYM cord-005453-4057qib7 1397 3 Th17 Th17 NNP cord-005453-4057qib7 1397 4 ratio ratio NN cord-005453-4057qib7 1397 5 was be VBD cord-005453-4057qib7 1397 6 noted note VBN cord-005453-4057qib7 1397 7 . . . cord-005453-4057qib7 1398 1 Conclusions conclusion NNS cord-005453-4057qib7 1398 2 : : : cord-005453-4057qib7 1399 1 This this DT cord-005453-4057qib7 1399 2 report report NN cord-005453-4057qib7 1399 3 suggest suggest VBP cord-005453-4057qib7 1399 4 that that IN cord-005453-4057qib7 1399 5 MSC MSC NNP cord-005453-4057qib7 1399 6 serial serial JJ cord-005453-4057qib7 1399 7 infusions infusion NNS cord-005453-4057qib7 1399 8 are be VBP cord-005453-4057qib7 1399 9 a a DT cord-005453-4057qib7 1399 10 promising promising JJ cord-005453-4057qib7 1399 11 therapy therapy NN cord-005453-4057qib7 1399 12 in in IN cord-005453-4057qib7 1399 13 aiding aid VBG cord-005453-4057qib7 1399 14 the the DT cord-005453-4057qib7 1399 15 respiratory respiratory JJ cord-005453-4057qib7 1399 16 failure failure NN cord-005453-4057qib7 1399 17 , , , cord-005453-4057qib7 1399 18 even even RB cord-005453-4057qib7 1399 19 in in IN cord-005453-4057qib7 1399 20 a a DT cord-005453-4057qib7 1399 21 pediatric pediatric JJ cord-005453-4057qib7 1399 22 patient patient NN cord-005453-4057qib7 1399 23 with with IN cord-005453-4057qib7 1399 24 FLNA FLNA NNP cord-005453-4057qib7 1399 25 mutation mutation NN cord-005453-4057qib7 1399 26 . . . cord-005453-4057qib7 1400 1 Intravenous intravenous JJ cord-005453-4057qib7 1400 2 administrations administration NNS cord-005453-4057qib7 1400 3 of of IN cord-005453-4057qib7 1400 4 allogeneic allogeneic NN cord-005453-4057qib7 1400 5 MSCs msc NNS cord-005453-4057qib7 1400 6 are be VBP cord-005453-4057qib7 1400 7 feasible feasible JJ cord-005453-4057qib7 1400 8 and and CC cord-005453-4057qib7 1400 9 safe safe JJ cord-005453-4057qib7 1400 10 without without IN cord-005453-4057qib7 1400 11 toxicity toxicity NN cord-005453-4057qib7 1400 12 . . . cord-005453-4057qib7 1401 1 Our -PRON- PRP$ cord-005453-4057qib7 1401 2 results result NNS cord-005453-4057qib7 1401 3 suggest suggest VBP cord-005453-4057qib7 1401 4 that that IN cord-005453-4057qib7 1401 5 to to TO cord-005453-4057qib7 1401 6 mitigate mitigate VB cord-005453-4057qib7 1401 7 lung lung NN cord-005453-4057qib7 1401 8 injury injury NN cord-005453-4057qib7 1401 9 , , , cord-005453-4057qib7 1401 10 MSCs MSCs NNP cord-005453-4057qib7 1401 11 may may MD cord-005453-4057qib7 1401 12 act act VB cord-005453-4057qib7 1401 13 as as IN cord-005453-4057qib7 1401 14 regulators regulator NNS cord-005453-4057qib7 1401 15 of of IN cord-005453-4057qib7 1401 16 Treg Treg NNP cord-005453-4057qib7 1401 17 and and CC cord-005453-4057qib7 1401 18 Th17 Th17 NNP cord-005453-4057qib7 1401 19 balance balance NN cord-005453-4057qib7 1401 20 . . . cord-005453-4057qib7 1402 1 Further further JJ cord-005453-4057qib7 1402 2 investigations investigation NNS cord-005453-4057qib7 1402 3 are be VBP cord-005453-4057qib7 1402 4 upcoming upcome VBG cord-005453-4057qib7 1402 5 to to TO cord-005453-4057qib7 1402 6 establish establish VB cord-005453-4057qib7 1402 7 the the DT cord-005453-4057qib7 1402 8 useful useful NN cord-005453-4057qib7 1402 9 of of IN cord-005453-4057qib7 1402 10 this this DT cord-005453-4057qib7 1402 11 therapeutic therapeutic JJ cord-005453-4057qib7 1402 12 proposal proposal NN cord-005453-4057qib7 1402 13 in in IN cord-005453-4057qib7 1402 14 interstitial interstitial JJ cord-005453-4057qib7 1402 15 lung lung NN cord-005453-4057qib7 1402 16 diseases disease NNS cord-005453-4057qib7 1402 17 in in IN cord-005453-4057qib7 1402 18 children child NNS cord-005453-4057qib7 1402 19 . . . cord-005453-4057qib7 1403 1 Disclosure disclosure NN cord-005453-4057qib7 1403 2 : : : cord-005453-4057qib7 1404 1 Nothig Nothig NNP cord-005453-4057qib7 1404 2 to to TO cord-005453-4057qib7 1404 3 declare declare VB cord-005453-4057qib7 1404 4 P078 p078 PRP cord-005453-4057qib7 1404 5 feasibility feasibility NN cord-005453-4057qib7 1404 6 of of IN cord-005453-4057qib7 1404 7 IL-15 IL-15 NNP cord-005453-4057qib7 1404 8 stimulated stimulate VBD cord-005453-4057qib7 1404 9 donor donor NN cord-005453-4057qib7 1404 10 NK NK NNP cord-005453-4057qib7 1404 11 cells cell NNS cord-005453-4057qib7 1404 12 manufacturing manufacture VBG cord-005453-4057qib7 1404 13 for for IN cord-005453-4057qib7 1404 14 early early JJ cord-005453-4057qib7 1404 15 infusion infusion NN cord-005453-4057qib7 1404 16 in in IN cord-005453-4057qib7 1404 17 patients patient NNS cord-005453-4057qib7 1404 18 with with IN cord-005453-4057qib7 1404 19 high high JJ cord-005453-4057qib7 1404 20 risk risk NN cord-005453-4057qib7 1404 21 acute acute JJ cord-005453-4057qib7 1404 22 myeloid myeloid NN cord-005453-4057qib7 1404 23 leukemia leukemia NN cord-005453-4057qib7 1404 24 undergoing undergo VBG cord-005453-4057qib7 1404 25 haploidentical haploidentical JJ cord-005453-4057qib7 1404 26 transplantation transplantation NN cord-005453-4057qib7 1404 27 Background Background NNP cord-005453-4057qib7 1404 28 : : : cord-005453-4057qib7 1404 29 NK NK NNP cord-005453-4057qib7 1404 30 cells cell NNS cord-005453-4057qib7 1404 31 provide provide VBP cord-005453-4057qib7 1404 32 a a DT cord-005453-4057qib7 1404 33 potent potent JJ cord-005453-4057qib7 1404 34 antitumor antitumor JJ cord-005453-4057qib7 1404 35 effect effect NN cord-005453-4057qib7 1404 36 in in IN cord-005453-4057qib7 1404 37 the the DT cord-005453-4057qib7 1404 38 setting setting NN cord-005453-4057qib7 1404 39 of of IN cord-005453-4057qib7 1404 40 manipulated manipulate VBN cord-005453-4057qib7 1404 41 haploidentical haploidentical JJ cord-005453-4057qib7 1404 42 hematopoietic hematopoietic JJ cord-005453-4057qib7 1404 43 stem stem NN cord-005453-4057qib7 1404 44 cell cell NN cord-005453-4057qib7 1404 45 transplant transplant NN cord-005453-4057qib7 1404 46 ( ( -LRB- cord-005453-4057qib7 1404 47 Haplo Haplo NNP cord-005453-4057qib7 1404 48 - - HYPH cord-005453-4057qib7 1404 49 HSCT HSCT NNP cord-005453-4057qib7 1404 50 ) ) -RRB- cord-005453-4057qib7 1404 51 . . . cord-005453-4057qib7 1405 1 We -PRON- PRP cord-005453-4057qib7 1405 2 propose propose VBP cord-005453-4057qib7 1405 3 a a DT cord-005453-4057qib7 1405 4 novel novel JJ cord-005453-4057qib7 1405 5 strategy strategy NN cord-005453-4057qib7 1405 6 to to TO cord-005453-4057qib7 1405 7 enhance enhance VB cord-005453-4057qib7 1405 8 the the DT cord-005453-4057qib7 1405 9 antitumor antitumor JJ cord-005453-4057qib7 1405 10 effect effect NN cord-005453-4057qib7 1405 11 of of IN cord-005453-4057qib7 1405 12 allogeneic allogeneic NN cord-005453-4057qib7 1405 13 transplant transplant NN cord-005453-4057qib7 1405 14 through through IN cord-005453-4057qib7 1405 15 the the DT cord-005453-4057qib7 1405 16 infusion infusion NN cord-005453-4057qib7 1405 17 of of IN cord-005453-4057qib7 1405 18 NK NK NNP cord-005453-4057qib7 1405 19 cells cell NNS cord-005453-4057qib7 1405 20 stimulated stimulate VBN cord-005453-4057qib7 1405 21 with with IN cord-005453-4057qib7 1405 22 IL-15 IL-15 NNP cord-005453-4057qib7 1405 23 exvivo exvivo NN cord-005453-4057qib7 1405 24 in in IN cord-005453-4057qib7 1405 25 adult adult NN cord-005453-4057qib7 1405 26 high high JJ cord-005453-4057qib7 1405 27 - - HYPH cord-005453-4057qib7 1405 28 risk risk NN cord-005453-4057qib7 1405 29 acute acute JJ cord-005453-4057qib7 1405 30 myeloid myeloid NN cord-005453-4057qib7 1405 31 leukemia leukemia NN cord-005453-4057qib7 1405 32 ( ( -LRB- cord-005453-4057qib7 1405 33 AML AML NNP cord-005453-4057qib7 1405 34 ) ) -RRB- cord-005453-4057qib7 1405 35 patients patient NNS cord-005453-4057qib7 1405 36 undergoing undergo VBG cord-005453-4057qib7 1405 37 unmanipulated unmanipulated JJ cord-005453-4057qib7 1405 38 Haplo Haplo NNP cord-005453-4057qib7 1405 39 - - HYPH cord-005453-4057qib7 1405 40 HSCT HSCT NNP cord-005453-4057qib7 1405 41 . . . cord-005453-4057qib7 1406 1 The the DT cord-005453-4057qib7 1406 2 objective objective NN cord-005453-4057qib7 1406 3 of of IN cord-005453-4057qib7 1406 4 this this DT cord-005453-4057qib7 1406 5 study study NN cord-005453-4057qib7 1406 6 was be VBD cord-005453-4057qib7 1406 7 to to TO cord-005453-4057qib7 1406 8 provide provide VB cord-005453-4057qib7 1406 9 efficiency efficiency NN cord-005453-4057qib7 1406 10 and and CC cord-005453-4057qib7 1406 11 productivity productivity NN cord-005453-4057qib7 1406 12 data datum NNS cord-005453-4057qib7 1406 13 obtained obtain VBN cord-005453-4057qib7 1406 14 in in IN cord-005453-4057qib7 1406 15 the the DT cord-005453-4057qib7 1406 16 manufactured manufactured JJ cord-005453-4057qib7 1406 17 cellular cellular JJ cord-005453-4057qib7 1406 18 products product NNS cord-005453-4057qib7 1406 19 infused infuse VBN cord-005453-4057qib7 1406 20 . . . cord-005453-4057qib7 1407 1 Methods method NNS cord-005453-4057qib7 1407 2 : : : cord-005453-4057qib7 1407 3 Selection selection NN cord-005453-4057qib7 1407 4 criteria criterion NNS cord-005453-4057qib7 1407 5 included include VBD cord-005453-4057qib7 1407 6 patients patient NNS cord-005453-4057qib7 1407 7 with with IN cord-005453-4057qib7 1407 8 highrisk highrisk NNP cord-005453-4057qib7 1407 9 AML AML NNP cord-005453-4057qib7 1407 10 undergoing undergo VBG cord-005453-4057qib7 1407 11 unmanipulated unmanipulated JJ cord-005453-4057qib7 1407 12 Haplo Haplo NNP cord-005453-4057qib7 1407 13 - - HYPH cord-005453-4057qib7 1407 14 HSCT HSCT NNP cord-005453-4057qib7 1407 15 . . . cord-005453-4057qib7 1408 1 Lymphoapheresis Lymphoapheresis NNP cord-005453-4057qib7 1408 2 of of IN cord-005453-4057qib7 1408 3 the the DT cord-005453-4057qib7 1408 4 haploidentical haploidentical JJ cord-005453-4057qib7 1408 5 donor donor NN cord-005453-4057qib7 1408 6 was be VBD cord-005453-4057qib7 1408 7 performed perform VBN cord-005453-4057qib7 1408 8 using use VBG cord-005453-4057qib7 1408 9 Spectra Spectra NNP cord-005453-4057qib7 1408 10 Optia Optia NNP cord-005453-4057qib7 1408 11 ( ( -LRB- cord-005453-4057qib7 1408 12 Terumo Terumo NNP cord-005453-4057qib7 1408 13 ® ® , cord-005453-4057qib7 1408 14 BCT BCT NNP cord-005453-4057qib7 1408 15 ) ) -RRB- cord-005453-4057qib7 1408 16 on on IN cord-005453-4057qib7 1408 17 days day NNS cord-005453-4057qib7 1408 18 +6 +6 CD cord-005453-4057qib7 1408 19 and and CC cord-005453-4057qib7 1408 20 +13 +13 NN cord-005453-4057qib7 1408 21 after after IN cord-005453-4057qib7 1408 22 transplant transplant NN cord-005453-4057qib7 1408 23 . . . cord-005453-4057qib7 1409 1 From from IN cord-005453-4057qib7 1409 2 the the DT cord-005453-4057qib7 1409 3 obtained obtain VBN cord-005453-4057qib7 1409 4 product product NN cord-005453-4057qib7 1409 5 a a DT cord-005453-4057qib7 1409 6 double double JJ cord-005453-4057qib7 1409 7 immunomagnetic immunomagnetic JJ cord-005453-4057qib7 1409 8 cellular cellular JJ cord-005453-4057qib7 1409 9 selection selection NN cord-005453-4057qib7 1409 10 with with IN cord-005453-4057qib7 1409 11 Clinimacs Clinimacs NNP cord-005453-4057qib7 1409 12 system system NN cord-005453-4057qib7 1410 1 ( ( -LRB- cord-005453-4057qib7 1410 2 Miltenyi Miltenyi NNP cord-005453-4057qib7 1410 3 Biotec Biotec NNP cord-005453-4057qib7 1410 4 ® ® NNP cord-005453-4057qib7 1410 5 ) ) -RRB- cord-005453-4057qib7 1410 6 was be VBD cord-005453-4057qib7 1410 7 performed perform VBN cord-005453-4057qib7 1410 8 in in IN cord-005453-4057qib7 1410 9 two two CD cord-005453-4057qib7 1410 10 steps step NNS cord-005453-4057qib7 1410 11 : : : cord-005453-4057qib7 1410 12 CD3 CD3 NNP cord-005453-4057qib7 1410 13 + + CC cord-005453-4057qib7 1410 14 depletion depletion NN cord-005453-4057qib7 1410 15 followed follow VBN cord-005453-4057qib7 1410 16 by by IN cord-005453-4057qib7 1410 17 positive positive JJ cord-005453-4057qib7 1410 18 CD56 CD56 NNP cord-005453-4057qib7 1410 19 + + CC cord-005453-4057qib7 1410 20 selection selection NN cord-005453-4057qib7 1410 21 . . . cord-005453-4057qib7 1411 1 The the DT cord-005453-4057qib7 1411 2 obtained obtain VBD cord-005453-4057qib7 1411 3 an an DT cord-005453-4057qib7 1411 4 enriched enriched JJ cord-005453-4057qib7 1411 5 cellular cellular JJ cord-005453-4057qib7 1411 6 product product NN cord-005453-4057qib7 1411 7 of of IN cord-005453-4057qib7 1411 8 CD3-CD56 cd3-cd56 NN cord-005453-4057qib7 1412 1 + + CC cord-005453-4057qib7 1412 2 NK NK NNP cord-005453-4057qib7 1412 3 cells cell NNS cord-005453-4057qib7 1412 4 was be VBD cord-005453-4057qib7 1412 5 incubated incubate VBN cord-005453-4057qib7 1412 6 with with IN cord-005453-4057qib7 1412 7 IL-15 IL-15 NNP cord-005453-4057qib7 1412 8 ( ( -LRB- cord-005453-4057qib7 1412 9 10 10 CD cord-005453-4057qib7 1412 10 ng ng NN cord-005453-4057qib7 1412 11 / / SYM cord-005453-4057qib7 1412 12 mL ml NN cord-005453-4057qib7 1412 13 ) ) -RRB- cord-005453-4057qib7 1412 14 between between IN cord-005453-4057qib7 1412 15 12 12 CD cord-005453-4057qib7 1412 16 and and CC cord-005453-4057qib7 1412 17 18 18 CD cord-005453-4057qib7 1412 18 hours hour NNS cord-005453-4057qib7 1412 19 at at IN cord-005453-4057qib7 1412 20 37ºC 37ºc CD cord-005453-4057qib7 1412 21 and and CC cord-005453-4057qib7 1412 22 5 5 CD cord-005453-4057qib7 1412 23 % % NN cord-005453-4057qib7 1412 24 CO2 co2 NN cord-005453-4057qib7 1412 25 in in IN cord-005453-4057qib7 1412 26 GMP GMP NNP cord-005453-4057qib7 1412 27 conditions condition NNS cord-005453-4057qib7 1412 28 . . . cord-005453-4057qib7 1413 1 Quality quality NN cord-005453-4057qib7 1413 2 and and CC cord-005453-4057qib7 1413 3 microbiological microbiological JJ cord-005453-4057qib7 1413 4 controls control NNS cord-005453-4057qib7 1413 5 were be VBD cord-005453-4057qib7 1413 6 performed perform VBN cord-005453-4057qib7 1413 7 at at IN cord-005453-4057qib7 1413 8 the the DT cord-005453-4057qib7 1413 9 end end NN cord-005453-4057qib7 1413 10 of of IN cord-005453-4057qib7 1413 11 each each DT cord-005453-4057qib7 1413 12 manufacturing manufacturing NN cord-005453-4057qib7 1413 13 step step NN cord-005453-4057qib7 1413 14 . . . cord-005453-4057qib7 1414 1 DxH DxH NNP cord-005453-4057qib7 1414 2 cellular cellular JJ cord-005453-4057qib7 1414 3 counters counter NNS cord-005453-4057qib7 1414 4 ( ( -LRB- cord-005453-4057qib7 1414 5 Beckman Beckman NNP cord-005453-4057qib7 1414 6 Coulter Coulter NNP cord-005453-4057qib7 1414 7 ® ® POS cord-005453-4057qib7 1414 8 ) ) -RRB- cord-005453-4057qib7 1414 9 and and CC cord-005453-4057qib7 1414 10 multiparametric multiparametric JJ cord-005453-4057qib7 1414 11 flow flow NN cord-005453-4057qib7 1414 12 cytometry cytometry NN cord-005453-4057qib7 1414 13 were be VBD cord-005453-4057qib7 1414 14 used use VBN cord-005453-4057qib7 1414 15 for for IN cord-005453-4057qib7 1414 16 lymphocyte lymphocyte NN cord-005453-4057qib7 1414 17 subpopulations subpopulation NNS cord-005453-4057qib7 1414 18 and and CC cord-005453-4057qib7 1414 19 viability viability NN cord-005453-4057qib7 1414 20 analysis analysis NN cord-005453-4057qib7 1414 21 ( ( -LRB- cord-005453-4057qib7 1414 22 Navios Navios NNP cord-005453-4057qib7 1414 23 cytometer cytometer NN cord-005453-4057qib7 1414 24 ; ; : cord-005453-4057qib7 1414 25 Beckman Beckman NNP cord-005453-4057qib7 1414 26 Coulter Coulter NNP cord-005453-4057qib7 1414 27 ® ® NNP cord-005453-4057qib7 1414 28 , , , cord-005453-4057qib7 1414 29 conjugated conjugate VBN cord-005453-4057qib7 1414 30 Monoclonal monoclonal JJ cord-005453-4057qib7 1414 31 antibodies antibody NNS cord-005453-4057qib7 1414 32 ; ; : cord-005453-4057qib7 1414 33 Miltenyi Miltenyi NNP cord-005453-4057qib7 1414 34 Biotec Biotec NNP cord-005453-4057qib7 1414 35 ® ® NNP cord-005453-4057qib7 1414 36 ) ) -RRB- cord-005453-4057qib7 1414 37 . . . cord-005453-4057qib7 1415 1 The the DT cord-005453-4057qib7 1415 2 final final JJ cord-005453-4057qib7 1415 3 product product NN cord-005453-4057qib7 1415 4 was be VBD cord-005453-4057qib7 1415 5 infused infuse VBN cord-005453-4057qib7 1415 6 intravenously intravenously RB cord-005453-4057qib7 1415 7 to to IN cord-005453-4057qib7 1415 8 the the DT cord-005453-4057qib7 1415 9 patient patient NN cord-005453-4057qib7 1415 10 on on IN cord-005453-4057qib7 1415 11 days day NNS cord-005453-4057qib7 1415 12 +8 +8 NNS cord-005453-4057qib7 1415 13 and and CC cord-005453-4057qib7 1415 14 +15 +15 CD cord-005453-4057qib7 1415 15 if if IN cord-005453-4057qib7 1415 16 manufacturing manufacturing NN cord-005453-4057qib7 1415 17 conditions condition NNS cord-005453-4057qib7 1415 18 were be VBD cord-005453-4057qib7 1415 19 met meet VBN cord-005453-4057qib7 1415 20 ( ( -LRB- cord-005453-4057qib7 1415 21 range range NN cord-005453-4057qib7 1415 22 of of IN cord-005453-4057qib7 1415 23 0.5 0.5 CD cord-005453-4057qib7 1415 24 - - HYPH cord-005453-4057qib7 1415 25 100x10 100x10 CD cord-005453-4057qib7 1415 26 6 6 CD cord-005453-4057qib7 1415 27 NK NK NNP cord-005453-4057qib7 1415 28 / / SYM cord-005453-4057qib7 1415 29 Kg Kg NNP cord-005453-4057qib7 1415 30 , , , cord-005453-4057qib7 1415 31 purity purity NN cord-005453-4057qib7 1415 32 ≥ ≥ CD cord-005453-4057qib7 1415 33 80 80 CD cord-005453-4057qib7 1415 34 % % NN cord-005453-4057qib7 1415 35 , , , cord-005453-4057qib7 1415 36 viability≥ viability≥ NNP cord-005453-4057qib7 1415 37 70 70 CD cord-005453-4057qib7 1415 38 % % NN cord-005453-4057qib7 1415 39 and and CC cord-005453-4057qib7 1415 40 < < NNP cord-005453-4057qib7 1415 41 1x10 1x10 CD cord-005453-4057qib7 1415 42 4 4 CD cord-005453-4057qib7 1415 43 CD3 CD3 NNP cord-005453-4057qib7 1415 44 + + CC cord-005453-4057qib7 1415 45 cells cell NNS cord-005453-4057qib7 1415 46 / / SYM cord-005453-4057qib7 1415 47 Kg Kg NNP cord-005453-4057qib7 1415 48 ) ) -RRB- cord-005453-4057qib7 1415 49 . . . cord-005453-4057qib7 1416 1 If if IN cord-005453-4057qib7 1416 2 not not RB cord-005453-4057qib7 1416 3 , , , cord-005453-4057qib7 1416 4 it -PRON- PRP cord-005453-4057qib7 1416 5 was be VBD cord-005453-4057qib7 1416 6 discarded discard VBN cord-005453-4057qib7 1416 7 . . . cord-005453-4057qib7 1417 1 NK NK NNP cord-005453-4057qib7 1417 2 cell cell NN cord-005453-4057qib7 1417 3 activation activation NN cord-005453-4057qib7 1417 4 in in IN cord-005453-4057qib7 1417 5 the the DT cord-005453-4057qib7 1417 6 product product NN cord-005453-4057qib7 1417 7 was be VBD cord-005453-4057qib7 1417 8 measured measure VBN cord-005453-4057qib7 1417 9 by by IN cord-005453-4057qib7 1417 10 the the DT cord-005453-4057qib7 1417 11 expression expression NN cord-005453-4057qib7 1417 12 of of IN cord-005453-4057qib7 1417 13 CD25 CD25 NNP cord-005453-4057qib7 1417 14 and and CC cord-005453-4057qib7 1417 15 CD69 CD69 NNP cord-005453-4057qib7 1417 16 . . . cord-005453-4057qib7 1418 1 Results result NNS cord-005453-4057qib7 1418 2 : : : cord-005453-4057qib7 1419 1 Between between IN cord-005453-4057qib7 1419 2 November November NNP cord-005453-4057qib7 1419 3 2017 2017 CD cord-005453-4057qib7 1419 4 and and CC cord-005453-4057qib7 1419 5 April April NNP cord-005453-4057qib7 1419 6 2018 2018 CD cord-005453-4057qib7 1419 7 , , , cord-005453-4057qib7 1419 8 3 3 CD cord-005453-4057qib7 1419 9 patients patient NNS cord-005453-4057qib7 1419 10 were be VBD cord-005453-4057qib7 1419 11 included include VBN cord-005453-4057qib7 1419 12 in in IN cord-005453-4057qib7 1419 13 this this DT cord-005453-4057qib7 1419 14 ongoing ongoing JJ cord-005453-4057qib7 1419 15 trial trial NN cord-005453-4057qib7 1419 16 . . . cord-005453-4057qib7 1420 1 Two two CD cord-005453-4057qib7 1420 2 products product NNS cord-005453-4057qib7 1420 3 were be VBD cord-005453-4057qib7 1420 4 manufactured manufacture VBN cord-005453-4057qib7 1420 5 for for IN cord-005453-4057qib7 1420 6 2 2 CD cord-005453-4057qib7 1420 7 of of IN cord-005453-4057qib7 1420 8 the the DT cord-005453-4057qib7 1420 9 patients patient NNS cord-005453-4057qib7 1420 10 , , , cord-005453-4057qib7 1420 11 and and CC cord-005453-4057qib7 1420 12 only only RB cord-005453-4057qib7 1420 13 one one CD cord-005453-4057qib7 1420 14 for for IN cord-005453-4057qib7 1420 15 the the DT cord-005453-4057qib7 1420 16 first first JJ cord-005453-4057qib7 1420 17 patient patient NN cord-005453-4057qib7 1420 18 , , , cord-005453-4057qib7 1420 19 due due IN cord-005453-4057qib7 1420 20 to to IN cord-005453-4057qib7 1420 21 transplant transplant NN cord-005453-4057qib7 1420 22 complications complication NNS cord-005453-4057qib7 1420 23 between between IN cord-005453-4057qib7 1420 24 first first JJ cord-005453-4057qib7 1420 25 and and CC cord-005453-4057qib7 1420 26 second second JJ cord-005453-4057qib7 1420 27 infusion infusion NN cord-005453-4057qib7 1420 28 . . . cord-005453-4057qib7 1421 1 One one CD cord-005453-4057qib7 1421 2 product product NN cord-005453-4057qib7 1421 3 did do VBD cord-005453-4057qib7 1421 4 not not RB cord-005453-4057qib7 1421 5 meet meet VB cord-005453-4057qib7 1421 6 minimum minimum JJ cord-005453-4057qib7 1421 7 viability viability NN cord-005453-4057qib7 1421 8 criteria criterion NNS cord-005453-4057qib7 1421 9 and and CC cord-005453-4057qib7 1421 10 was be VBD cord-005453-4057qib7 1421 11 discarded discard VBN cord-005453-4057qib7 1421 12 . . . cord-005453-4057qib7 1422 1 In in IN cord-005453-4057qib7 1422 2 the the DT cord-005453-4057qib7 1422 3 infused infuse VBN cord-005453-4057qib7 1422 4 final final JJ cord-005453-4057qib7 1422 5 products product NNS cord-005453-4057qib7 1422 6 mean mean VBP cord-005453-4057qib7 1422 7 and and CC cord-005453-4057qib7 1422 8 SEM SEM NNP cord-005453-4057qib7 1422 9 of of IN cord-005453-4057qib7 1422 10 NK NK NNP cord-005453-4057qib7 1422 11 cell cell NN cord-005453-4057qib7 1422 12 purity purity NN cord-005453-4057qib7 1422 13 , , , cord-005453-4057qib7 1422 14 recovery recovery NN cord-005453-4057qib7 1422 15 and and CC cord-005453-4057qib7 1422 16 viability viability NN cord-005453-4057qib7 1422 17 were be VBD cord-005453-4057qib7 1422 18 83.7%±4.4 83.7%±4.4 CD cord-005453-4057qib7 1422 19 , , , cord-005453-4057qib7 1422 20 30.9%±4 30.9%±4 NNP cord-005453-4057qib7 1422 21 and and CC cord-005453-4057qib7 1422 22 76.3%±17.4 76.3%±17.4 CD cord-005453-4057qib7 1422 23 , , , cord-005453-4057qib7 1422 24 respectively respectively RB cord-005453-4057qib7 1422 25 . . . cord-005453-4057qib7 1423 1 Log Log NNP cord-005453-4057qib7 1423 2 CD3 CD3 NNP cord-005453-4057qib7 1423 3 + + CC cord-005453-4057qib7 1423 4 depletion depletion NN cord-005453-4057qib7 1423 5 ranged range VBN cord-005453-4057qib7 1423 6 between between IN cord-005453-4057qib7 1423 7 -5.48 -5.48 CD cord-005453-4057qib7 1423 8 and and CC cord-005453-4057qib7 1423 9 -6.03 -6.03 CD cord-005453-4057qib7 1423 10 . . . cord-005453-4057qib7 1424 1 Median median JJ cord-005453-4057qib7 1424 2 infused infuse VBN cord-005453-4057qib7 1424 3 doses dose NNS cord-005453-4057qib7 1424 4 of of IN cord-005453-4057qib7 1424 5 NK NK NNP cord-005453-4057qib7 1424 6 cells cell NNS cord-005453-4057qib7 1424 7 and and CC cord-005453-4057qib7 1424 8 CD3 cd3 NN cord-005453-4057qib7 1424 9 + + CC cord-005453-4057qib7 1425 1 cells cell NNS cord-005453-4057qib7 1425 2 per per IN cord-005453-4057qib7 1425 3 kg kg NNS cord-005453-4057qib7 1425 4 were be VBD cord-005453-4057qib7 1425 5 3.78x10 3.78x10 CD cord-005453-4057qib7 1425 6 6 6 CD cord-005453-4057qib7 1425 7 ( ( -LRB- cord-005453-4057qib7 1425 8 2.8x10 2.8x10 CD cord-005453-4057qib7 1425 9 6 6 CD cord-005453-4057qib7 1425 10 -4.57x10 -4.57x10 CD cord-005453-4057qib7 1425 11 6 6 CD cord-005453-4057qib7 1425 12 ) ) -RRB- cord-005453-4057qib7 1425 13 and and CC cord-005453-4057qib7 1425 14 114 114 CD cord-005453-4057qib7 1425 15 ( ( -LRB- cord-005453-4057qib7 1425 16 87 87 CD cord-005453-4057qib7 1425 17 - - SYM cord-005453-4057qib7 1425 18 532 532 CD cord-005453-4057qib7 1425 19 ) ) -RRB- cord-005453-4057qib7 1425 20 . . . cord-005453-4057qib7 1426 1 Complete complete JJ cord-005453-4057qib7 1426 2 manufacturing manufacturing NN cord-005453-4057qib7 1426 3 data datum NNS cord-005453-4057qib7 1426 4 of of IN cord-005453-4057qib7 1426 5 all all DT cord-005453-4057qib7 1426 6 5 5 CD cord-005453-4057qib7 1426 7 procedures procedure NNS cord-005453-4057qib7 1426 8 are be VBP cord-005453-4057qib7 1426 9 shown show VBN cord-005453-4057qib7 1426 10 in in IN cord-005453-4057qib7 1426 11 Table Table NNP cord-005453-4057qib7 1426 12 1 1 CD cord-005453-4057qib7 1426 13 Background Background NNP cord-005453-4057qib7 1426 14 : : : cord-005453-4057qib7 1427 1 Cytokine cytokine NN cord-005453-4057qib7 1427 2 - - HYPH cord-005453-4057qib7 1427 3 induced induce VBN cord-005453-4057qib7 1427 4 killer killer NN cord-005453-4057qib7 1427 5 ( ( -LRB- cord-005453-4057qib7 1427 6 CIK CIK NNP cord-005453-4057qib7 1427 7 ) ) -RRB- cord-005453-4057qib7 1427 8 cells cell NNS cord-005453-4057qib7 1427 9 are be VBP cord-005453-4057qib7 1427 10 a a DT cord-005453-4057qib7 1427 11 promising promising JJ cord-005453-4057qib7 1427 12 immunotherapeutic immunotherapeutic NN cord-005453-4057qib7 1427 13 approach approach NN cord-005453-4057qib7 1427 14 to to IN cord-005453-4057qib7 1427 15 combat combat VB cord-005453-4057qib7 1427 16 relapse relapse NN cord-005453-4057qib7 1427 17 following follow VBG cord-005453-4057qib7 1427 18 allogeneic allogeneic NN cord-005453-4057qib7 1427 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 1427 20 stem stem NN cord-005453-4057qib7 1427 21 cell cell NN cord-005453-4057qib7 1427 22 transplantation transplantation NN cord-005453-4057qib7 1427 23 ( ( -LRB- cord-005453-4057qib7 1427 24 HSCT HSCT NNP cord-005453-4057qib7 1427 25 ) ) -RRB- cord-005453-4057qib7 1427 26 for for IN cord-005453-4057qib7 1427 27 acute acute JJ cord-005453-4057qib7 1427 28 leukemia leukemia NN cord-005453-4057qib7 1427 29 or or CC cord-005453-4057qib7 1427 30 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 1427 31 syndrome syndrome NN cord-005453-4057qib7 1427 32 . . . cord-005453-4057qib7 1428 1 To to TO cord-005453-4057qib7 1428 2 show show VB cord-005453-4057qib7 1428 3 safety safety NN cord-005453-4057qib7 1428 4 and and CC cord-005453-4057qib7 1428 5 efficacy efficacy NN cord-005453-4057qib7 1428 6 , , , cord-005453-4057qib7 1428 7 a a DT cord-005453-4057qib7 1428 8 multicenter multicenter JJ cord-005453-4057qib7 1428 9 clinical clinical JJ cord-005453-4057qib7 1428 10 study study NN cord-005453-4057qib7 1428 11 with with IN cord-005453-4057qib7 1428 12 20 20 CD cord-005453-4057qib7 1428 13 pediatric pediatric JJ cord-005453-4057qib7 1428 14 and and CC cord-005453-4057qib7 1428 15 20 20 CD cord-005453-4057qib7 1428 16 adult adult NN cord-005453-4057qib7 1428 17 patients patient NNS cord-005453-4057qib7 1428 18 including include VBG cord-005453-4057qib7 1428 19 up up IN cord-005453-4057qib7 1428 20 to to TO cord-005453-4057qib7 1428 21 eight eight CD cord-005453-4057qib7 1428 22 CIK CIK NNP cord-005453-4057qib7 1428 23 cell cell NN cord-005453-4057qib7 1428 24 applications application NNS cord-005453-4057qib7 1428 25 with with IN cord-005453-4057qib7 1428 26 escalating escalate VBG cord-005453-4057qib7 1428 27 doses dose NNS cord-005453-4057qib7 1428 28 is be VBZ cord-005453-4057qib7 1428 29 ongoing ongoing JJ cord-005453-4057qib7 1428 30 . . . cord-005453-4057qib7 1429 1 Methods method NNS cord-005453-4057qib7 1429 2 : : : cord-005453-4057qib7 1429 3 We -PRON- PRP cord-005453-4057qib7 1429 4 favor favor VBP cord-005453-4057qib7 1429 5 single single JJ cord-005453-4057qib7 1429 6 large large JJ cord-005453-4057qib7 1429 7 scale scale NN cord-005453-4057qib7 1429 8 CIK cik NN cord-005453-4057qib7 1429 9 cell cell NN cord-005453-4057qib7 1429 10 generation generation NN cord-005453-4057qib7 1429 11 with with IN cord-005453-4057qib7 1429 12 the the DT cord-005453-4057qib7 1429 13 aim aim NN cord-005453-4057qib7 1429 14 to to TO cord-005453-4057qib7 1429 15 apply apply VB cord-005453-4057qib7 1429 16 fresh fresh JJ cord-005453-4057qib7 1429 17 CIK CIK NNP cord-005453-4057qib7 1429 18 cells cell NNS cord-005453-4057qib7 1429 19 and and CC cord-005453-4057qib7 1429 20 cryopreserve cryopreserve VB cord-005453-4057qib7 1429 21 ready ready JJ cord-005453-4057qib7 1429 22 - - HYPH cord-005453-4057qib7 1429 23 for for IN cord-005453-4057qib7 1429 24 - - HYPH cord-005453-4057qib7 1429 25 use use NN cord-005453-4057qib7 1429 26 doses dose NNS cord-005453-4057qib7 1429 27 according accord VBG cord-005453-4057qib7 1429 28 to to IN cord-005453-4057qib7 1429 29 the the DT cord-005453-4057qib7 1429 30 study study NN cord-005453-4057qib7 1429 31 protocol protocol NN cord-005453-4057qib7 1429 32 in in IN cord-005453-4057qib7 1429 33 contrast contrast NN cord-005453-4057qib7 1429 34 to to IN cord-005453-4057qib7 1429 35 recurrent recurrent JJ cord-005453-4057qib7 1429 36 manufacturing manufacturing NN cord-005453-4057qib7 1429 37 . . . cord-005453-4057qib7 1430 1 Therefore therefore RB cord-005453-4057qib7 1430 2 cryopreserved cryopreserve VBN cord-005453-4057qib7 1430 3 CIK CIK NNP cord-005453-4057qib7 1430 4 cells cell NNS cord-005453-4057qib7 1430 5 were be VBD cord-005453-4057qib7 1430 6 tested test VBN cord-005453-4057qib7 1430 7 against against IN cord-005453-4057qib7 1430 8 freshly freshly RB cord-005453-4057qib7 1430 9 generated generate VBN cord-005453-4057qib7 1430 10 CIK CIK NNP cord-005453-4057qib7 1430 11 cells cell NNS cord-005453-4057qib7 1430 12 to to TO cord-005453-4057qib7 1430 13 approve approve VB cord-005453-4057qib7 1430 14 equivalence equivalence NN cord-005453-4057qib7 1430 15 . . . cord-005453-4057qib7 1431 1 Furthermore furthermore RB cord-005453-4057qib7 1431 2 , , , cord-005453-4057qib7 1431 3 an an DT cord-005453-4057qib7 1431 4 alternative alternative JJ cord-005453-4057qib7 1431 5 medium medium NN cord-005453-4057qib7 1431 6 supplement supplement NN cord-005453-4057qib7 1431 7 for for IN cord-005453-4057qib7 1431 8 CIK CIK NNP cord-005453-4057qib7 1431 9 cell cell NN cord-005453-4057qib7 1431 10 culturing culturing NN cord-005453-4057qib7 1431 11 was be VBD cord-005453-4057qib7 1431 12 investigated investigate VBN cord-005453-4057qib7 1431 13 to to TO cord-005453-4057qib7 1431 14 avoid avoid VB cord-005453-4057qib7 1431 15 supply supply NN cord-005453-4057qib7 1431 16 bottlenecks bottleneck NNS cord-005453-4057qib7 1431 17 in in IN cord-005453-4057qib7 1431 18 AB ab NN cord-005453-4057qib7 1431 19 - - HYPH cord-005453-4057qib7 1431 20 Serum serum NN cord-005453-4057qib7 1431 21 . . . cord-005453-4057qib7 1432 1 Results result NNS cord-005453-4057qib7 1432 2 : : : cord-005453-4057qib7 1433 1 Fresh Fresh NNP cord-005453-4057qib7 1433 2 Frozen Frozen NNP cord-005453-4057qib7 1433 3 Plasma Plasma NNP cord-005453-4057qib7 1433 4 ( ( -LRB- cord-005453-4057qib7 1433 5 FFP FFP NNP cord-005453-4057qib7 1433 6 ) ) -RRB- cord-005453-4057qib7 1433 7 , , , cord-005453-4057qib7 1433 8 platelet platelet NN cord-005453-4057qib7 1433 9 lysate lysate NN cord-005453-4057qib7 1433 10 ( ( -LRB- cord-005453-4057qib7 1433 11 PL pl NN cord-005453-4057qib7 1433 12 ) ) -RRB- cord-005453-4057qib7 1433 13 and and CC cord-005453-4057qib7 1433 14 AB ab NN cord-005453-4057qib7 1433 15 - - HYPH cord-005453-4057qib7 1433 16 serum serum NN cord-005453-4057qib7 1433 17 in in IN cord-005453-4057qib7 1433 18 CIK CIK NNP cord-005453-4057qib7 1433 19 cell cell NN cord-005453-4057qib7 1433 20 culture culture NN cord-005453-4057qib7 1433 21 showed show VBD cord-005453-4057qib7 1433 22 median median JJ cord-005453-4057qib7 1433 23 expansion expansion NN cord-005453-4057qib7 1433 24 rates rate NNS cord-005453-4057qib7 1433 25 of of IN cord-005453-4057qib7 1433 26 10-fold 10-fold CD cord-005453-4057qib7 1433 27 , , , cord-005453-4057qib7 1433 28 whereas whereas IN cord-005453-4057qib7 1433 29 cultivation cultivation NN cord-005453-4057qib7 1433 30 without without IN cord-005453-4057qib7 1433 31 medium medium JJ cord-005453-4057qib7 1433 32 additive additive NN cord-005453-4057qib7 1433 33 resulted result VBD cord-005453-4057qib7 1433 34 in in IN cord-005453-4057qib7 1433 35 significantly significantly RB cord-005453-4057qib7 1433 36 lower low JJR cord-005453-4057qib7 1433 37 proliferation proliferation NN cord-005453-4057qib7 1433 38 ( ( -LRB- cord-005453-4057qib7 1433 39 p p NN cord-005453-4057qib7 1433 40 < < XX cord-005453-4057qib7 1433 41 0.01 0.01 CD cord-005453-4057qib7 1433 42 ) ) -RRB- cord-005453-4057qib7 1433 43 . . . cord-005453-4057qib7 1434 1 CIK CIK NNP cord-005453-4057qib7 1434 2 cell cell NN cord-005453-4057qib7 1434 3 composition composition NN cord-005453-4057qib7 1434 4 including include VBG cord-005453-4057qib7 1434 5 T t NN cord-005453-4057qib7 1434 6 cells cell NNS cord-005453-4057qib7 1434 7 , , , cord-005453-4057qib7 1434 8 NK NK NNP cord-005453-4057qib7 1434 9 like like IN cord-005453-4057qib7 1434 10 T t NN cord-005453-4057qib7 1434 11 cells cell NNS cord-005453-4057qib7 1434 12 and and CC cord-005453-4057qib7 1434 13 a a DT cord-005453-4057qib7 1434 14 minor minor JJ cord-005453-4057qib7 1434 15 part part NN cord-005453-4057qib7 1434 16 of of IN cord-005453-4057qib7 1434 17 NK NK NNP cord-005453-4057qib7 1434 18 cells cell NNS cord-005453-4057qib7 1434 19 was be VBD cord-005453-4057qib7 1434 20 not not RB cord-005453-4057qib7 1434 21 significantly significantly RB cord-005453-4057qib7 1434 22 influenced influence VBN cord-005453-4057qib7 1434 23 by by IN cord-005453-4057qib7 1434 24 changing change VBG cord-005453-4057qib7 1434 25 the the DT cord-005453-4057qib7 1434 26 medium medium JJ cord-005453-4057qib7 1434 27 additive additive NN cord-005453-4057qib7 1434 28 . . . cord-005453-4057qib7 1435 1 Moreover moreover RB cord-005453-4057qib7 1435 2 , , , cord-005453-4057qib7 1435 3 neither neither CC cord-005453-4057qib7 1435 4 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1435 5 against against IN cord-005453-4057qib7 1435 6 THP-1 THP-1 NNP cord-005453-4057qib7 1435 7 cells cell NNS cord-005453-4057qib7 1435 8 nor nor CC cord-005453-4057qib7 1435 9 CD25 cd25 JJ cord-005453-4057qib7 1435 10 expression expression NN cord-005453-4057qib7 1435 11 on on IN cord-005453-4057qib7 1435 12 NK NK NNP cord-005453-4057qib7 1435 13 like like IN cord-005453-4057qib7 1435 14 T t NN cord-005453-4057qib7 1435 15 cells cell NNS cord-005453-4057qib7 1435 16 were be VBD cord-005453-4057qib7 1435 17 significantly significantly RB cord-005453-4057qib7 1435 18 influenced influence VBN cord-005453-4057qib7 1435 19 by by IN cord-005453-4057qib7 1435 20 the the DT cord-005453-4057qib7 1435 21 different different JJ cord-005453-4057qib7 1435 22 medium medium JJ cord-005453-4057qib7 1435 23 additives additive NNS cord-005453-4057qib7 1435 24 . . . cord-005453-4057qib7 1436 1 For for IN cord-005453-4057qib7 1436 2 CIK CIK NNP cord-005453-4057qib7 1436 3 cell cell NN cord-005453-4057qib7 1436 4 generation generation NN cord-005453-4057qib7 1436 5 either either CC cord-005453-4057qib7 1436 6 ficollized ficollize VBD cord-005453-4057qib7 1436 7 peripheral peripheral JJ cord-005453-4057qib7 1436 8 blood blood NN cord-005453-4057qib7 1436 9 ( ( -LRB- cord-005453-4057qib7 1436 10 PB PB NNP cord-005453-4057qib7 1436 11 ) ) -RRB- cord-005453-4057qib7 1436 12 or or CC cord-005453-4057qib7 1436 13 unstimulated unstimulated JJ cord-005453-4057qib7 1436 14 leukapheresis leukapheresis NNP cord-005453-4057qib7 1436 15 ( ( -LRB- cord-005453-4057qib7 1436 16 LP LP NNP cord-005453-4057qib7 1436 17 ) ) -RRB- cord-005453-4057qib7 1436 18 products product NNS cord-005453-4057qib7 1436 19 were be VBD cord-005453-4057qib7 1436 20 utilized utilize VBN cord-005453-4057qib7 1436 21 . . . cord-005453-4057qib7 1437 1 With with IN cord-005453-4057qib7 1437 2 regard regard NN cord-005453-4057qib7 1437 3 to to IN cord-005453-4057qib7 1437 4 repeated repeat VBN cord-005453-4057qib7 1437 5 manufacturing manufacturing NN cord-005453-4057qib7 1437 6 within within IN cord-005453-4057qib7 1437 7 the the DT cord-005453-4057qib7 1437 8 clinical clinical JJ cord-005453-4057qib7 1437 9 study study NN cord-005453-4057qib7 1437 10 , , , cord-005453-4057qib7 1437 11 also also RB cord-005453-4057qib7 1437 12 cryopreserved cryopreserve VBD cord-005453-4057qib7 1437 13 LP LP NNP cord-005453-4057qib7 1437 14 and and CC cord-005453-4057qib7 1437 15 PBSC PBSC NNP cord-005453-4057qib7 1437 16 as as IN cord-005453-4057qib7 1437 17 starting start VBG cord-005453-4057qib7 1437 18 material material NN cord-005453-4057qib7 1437 19 came come VBD cord-005453-4057qib7 1437 20 into into IN cord-005453-4057qib7 1437 21 the the DT cord-005453-4057qib7 1437 22 focus focus NN cord-005453-4057qib7 1437 23 of of IN cord-005453-4057qib7 1437 24 interest interest NN cord-005453-4057qib7 1437 25 . . . cord-005453-4057qib7 1438 1 Comparing compare VBG cord-005453-4057qib7 1438 2 CIK CIK NNP cord-005453-4057qib7 1438 3 cell cell NN cord-005453-4057qib7 1438 4 expansion expansion NN cord-005453-4057qib7 1438 5 rates rate NNS cord-005453-4057qib7 1438 6 , , , cord-005453-4057qib7 1438 7 no no DT cord-005453-4057qib7 1438 8 significant significant JJ cord-005453-4057qib7 1438 9 differences difference NNS cord-005453-4057qib7 1438 10 for for IN cord-005453-4057qib7 1438 11 the the DT cord-005453-4057qib7 1438 12 entire entire JJ cord-005453-4057qib7 1438 13 CIK CIK NNP cord-005453-4057qib7 1438 14 cells cell NNS cord-005453-4057qib7 1438 15 and and CC cord-005453-4057qib7 1438 16 the the DT cord-005453-4057qib7 1438 17 subgroup subgroup NN cord-005453-4057qib7 1438 18 of of IN cord-005453-4057qib7 1438 19 T T NNP cord-005453-4057qib7 1438 20 cells cell NNS cord-005453-4057qib7 1438 21 were be VBD cord-005453-4057qib7 1438 22 detected detect VBN cord-005453-4057qib7 1438 23 between between IN cord-005453-4057qib7 1438 24 the the DT cord-005453-4057qib7 1438 25 four four CD cord-005453-4057qib7 1438 26 starting start VBG cord-005453-4057qib7 1438 27 materials material NNS cord-005453-4057qib7 1438 28 . . . cord-005453-4057qib7 1439 1 Cryopreservation Cryopreservation NNP cord-005453-4057qib7 1439 2 of of IN cord-005453-4057qib7 1439 3 CIK CIK NNP cord-005453-4057qib7 1439 4 cells cell NNS cord-005453-4057qib7 1439 5 had have VBD cord-005453-4057qib7 1439 6 no no DT cord-005453-4057qib7 1439 7 significant significant JJ cord-005453-4057qib7 1439 8 effect effect NN cord-005453-4057qib7 1439 9 on on IN cord-005453-4057qib7 1439 10 CIK CIK NNP cord-005453-4057qib7 1439 11 cell cell NN cord-005453-4057qib7 1439 12 composition composition NN cord-005453-4057qib7 1439 13 , , , cord-005453-4057qib7 1439 14 cytotoxicity cytotoxicity NN cord-005453-4057qib7 1439 15 and and CC cord-005453-4057qib7 1439 16 CD25 cd25 JJ cord-005453-4057qib7 1439 17 expression expression NN cord-005453-4057qib7 1439 18 on on IN cord-005453-4057qib7 1439 19 NK NK NNP cord-005453-4057qib7 1439 20 like like IN cord-005453-4057qib7 1439 21 T t NN cord-005453-4057qib7 1439 22 cells cell NNS cord-005453-4057qib7 1439 23 . . . cord-005453-4057qib7 1440 1 A a DT cord-005453-4057qib7 1440 2 small small JJ cord-005453-4057qib7 1440 3 , , , cord-005453-4057qib7 1440 4 albeit albeit IN cord-005453-4057qib7 1440 5 not not RB cord-005453-4057qib7 1440 6 significant significant JJ cord-005453-4057qib7 1440 7 effect effect NN cord-005453-4057qib7 1440 8 of of IN cord-005453-4057qib7 1440 9 cryopreservation cryopreservation NN cord-005453-4057qib7 1440 10 on on IN cord-005453-4057qib7 1440 11 viability viability NN cord-005453-4057qib7 1440 12 was be VBD cord-005453-4057qib7 1440 13 detected detect VBN cord-005453-4057qib7 1440 14 , , , cord-005453-4057qib7 1440 15 which which WDT cord-005453-4057qib7 1440 16 was be VBD cord-005453-4057qib7 1440 17 86.1 86.1 CD cord-005453-4057qib7 1440 18 % % NN cord-005453-4057qib7 1440 19 before before RB cord-005453-4057qib7 1440 20 and and CC cord-005453-4057qib7 1440 21 79.4 79.4 CD cord-005453-4057qib7 1440 22 % % NN cord-005453-4057qib7 1440 23 after after IN cord-005453-4057qib7 1440 24 freezing freeze VBG cord-005453-4057qib7 1440 25 and and CC cord-005453-4057qib7 1440 26 thawing thawing NN cord-005453-4057qib7 1440 27 . . . cord-005453-4057qib7 1441 1 Conclusions conclusion NNS cord-005453-4057qib7 1441 2 : : : cord-005453-4057qib7 1442 1 The the DT cord-005453-4057qib7 1442 2 challenge challenge NN cord-005453-4057qib7 1442 3 was be VBD cord-005453-4057qib7 1442 4 an an DT cord-005453-4057qib7 1442 5 efficient efficient JJ cord-005453-4057qib7 1442 6 time- time- NN cord-005453-4057qib7 1442 7 , , , cord-005453-4057qib7 1442 8 personal personal JJ cord-005453-4057qib7 1442 9 - - HYPH cord-005453-4057qib7 1442 10 and and CC cord-005453-4057qib7 1442 11 cost cost NN cord-005453-4057qib7 1442 12 saving saving NN cord-005453-4057qib7 1442 13 production production NN cord-005453-4057qib7 1442 14 of of IN cord-005453-4057qib7 1442 15 CIK CIK NNP cord-005453-4057qib7 1442 16 cells cell NNS cord-005453-4057qib7 1442 17 within within IN cord-005453-4057qib7 1442 18 the the DT cord-005453-4057qib7 1442 19 clinical clinical JJ cord-005453-4057qib7 1442 20 study study NN cord-005453-4057qib7 1442 21 . . . cord-005453-4057qib7 1443 1 Introducing introduce VBG cord-005453-4057qib7 1443 2 FFP FFP NNP cord-005453-4057qib7 1443 3 enabled enable VBD cord-005453-4057qib7 1443 4 CIK CIK NNP cord-005453-4057qib7 1443 5 cell cell NN cord-005453-4057qib7 1443 6 manufacturing manufacturing NN cord-005453-4057qib7 1443 7 for for IN cord-005453-4057qib7 1443 8 an an DT cord-005453-4057qib7 1443 9 increased increase VBN cord-005453-4057qib7 1443 10 patient patient JJ cord-005453-4057qib7 1443 11 cohort cohort NN cord-005453-4057qib7 1443 12 by by IN cord-005453-4057qib7 1443 13 avoiding avoid VBG cord-005453-4057qib7 1443 14 supply supply NN cord-005453-4057qib7 1443 15 bottlenecks bottleneck NNS cord-005453-4057qib7 1443 16 in in IN cord-005453-4057qib7 1443 17 AB ab NN cord-005453-4057qib7 1443 18 - - HYPH cord-005453-4057qib7 1443 19 serum serum NN cord-005453-4057qib7 1443 20 . . . cord-005453-4057qib7 1444 1 Furthermore furthermore RB cord-005453-4057qib7 1444 2 , , , cord-005453-4057qib7 1444 3 cryopreservation cryopreservation NN cord-005453-4057qib7 1444 4 allows allow VBZ cord-005453-4057qib7 1444 5 the the DT cord-005453-4057qib7 1444 6 storage storage NN cord-005453-4057qib7 1444 7 of of IN cord-005453-4057qib7 1444 8 ready ready JJ cord-005453-4057qib7 1444 9 - - HYPH cord-005453-4057qib7 1444 10 for for IN cord-005453-4057qib7 1444 11 - - HYPH cord-005453-4057qib7 1444 12 use use NN cord-005453-4057qib7 1444 13 CIK CIK NNP cord-005453-4057qib7 1444 14 cell cell NN cord-005453-4057qib7 1444 15 doses dose NNS cord-005453-4057qib7 1444 16 fulfilling fulfil VBG cord-005453-4057qib7 1444 17 the the DT cord-005453-4057qib7 1444 18 demands demand NNS cord-005453-4057qib7 1444 19 of of IN cord-005453-4057qib7 1444 20 the the DT cord-005453-4057qib7 1444 21 clinical clinical JJ cord-005453-4057qib7 1444 22 study study NN cord-005453-4057qib7 1444 23 . . . cord-005453-4057qib7 1445 1 Clinical clinical JJ cord-005453-4057qib7 1445 2 Trial Trial NNP cord-005453-4057qib7 1445 3 Registry Registry NNP cord-005453-4057qib7 1445 4 : : : cord-005453-4057qib7 1446 1 EudraCT EudraCT NNP cord-005453-4057qib7 1446 2 Number Number NNP cord-005453-4057qib7 1446 3 2013 2013 CD cord-005453-4057qib7 1446 4 - - HYPH cord-005453-4057qib7 1446 5 005446 005446 CD cord-005453-4057qib7 1446 6 - - HYPH cord-005453-4057qib7 1446 7 11 11 CD cord-005453-4057qib7 1446 8 Disclosure disclosure NN cord-005453-4057qib7 1446 9 : : : cord-005453-4057qib7 1446 10 Nothing nothing NN cord-005453-4057qib7 1446 11 to to TO cord-005453-4057qib7 1446 12 declare declare VB cord-005453-4057qib7 1446 13 . . . cord-005453-4057qib7 1447 1 Automated automated JJ cord-005453-4057qib7 1447 2 generation generation NN cord-005453-4057qib7 1447 3 of of IN cord-005453-4057qib7 1447 4 CD45RA CD45RA NNP cord-005453-4057qib7 1447 5 depleted deplete VBN cord-005453-4057qib7 1447 6 donor donor NN cord-005453-4057qib7 1447 7 lymphocyte lymphocyte NN cord-005453-4057qib7 1447 8 infusion infusion NN cord-005453-4057qib7 1447 9 ( ( -LRB- cord-005453-4057qib7 1447 10 DLI DLI NNP cord-005453-4057qib7 1447 11 ) ) -RRB- cord-005453-4057qib7 1447 12 with with IN cord-005453-4057qib7 1447 13 the the DT cord-005453-4057qib7 1447 14 clinimacs clinimacs NNP cord-005453-4057qib7 1447 15 prodigy prodigy NN cord-005453-4057qib7 1448 1 ® ® . cord-005453-4057qib7 1449 1 CD45RA cd45ra NN cord-005453-4057qib7 1449 2 system system NN cord-005453-4057qib7 1449 3 1 1 CD cord-005453-4057qib7 1449 4 , , , cord-005453-4057qib7 1449 5 2 2 CD cord-005453-4057qib7 1449 6 Methods method NNS cord-005453-4057qib7 1450 1 : : : cord-005453-4057qib7 1450 2 The the DT cord-005453-4057qib7 1450 3 current current JJ cord-005453-4057qib7 1450 4 CliniMACS CliniMACS NNP cord-005453-4057qib7 1450 5 CD45RA CD45RA NNP cord-005453-4057qib7 1450 6 System System NNP cord-005453-4057qib7 1450 7 was be VBD cord-005453-4057qib7 1450 8 developed develop VBN cord-005453-4057qib7 1450 9 for for IN cord-005453-4057qib7 1450 10 graft graft NN cord-005453-4057qib7 1450 11 engineering engineering NN cord-005453-4057qib7 1450 12 . . . cord-005453-4057qib7 1451 1 Up up IN cord-005453-4057qib7 1451 2 to to TO cord-005453-4057qib7 1451 3 20x10e9 20x10e9 CD cord-005453-4057qib7 1451 4 magnetically magnetically RB cord-005453-4057qib7 1451 5 labeled label VBN cord-005453-4057qib7 1451 6 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 1451 7 cells cell NNS cord-005453-4057qib7 1451 8 from from IN cord-005453-4057qib7 1451 9 leukapheresis leukapheresis NN cord-005453-4057qib7 1451 10 products product NNS cord-005453-4057qib7 1451 11 can can MD cord-005453-4057qib7 1451 12 be be VB cord-005453-4057qib7 1451 13 depleted deplete VBN cord-005453-4057qib7 1451 14 from from IN cord-005453-4057qib7 1451 15 up up IN cord-005453-4057qib7 1451 16 to to IN cord-005453-4057qib7 1451 17 50x10e9 50x10e9 CD cord-005453-4057qib7 1451 18 white white JJ cord-005453-4057qib7 1451 19 blood blood NN cord-005453-4057qib7 1451 20 cells cell NNS cord-005453-4057qib7 1451 21 ( ( -LRB- cord-005453-4057qib7 1451 22 WBC WBC NNP cord-005453-4057qib7 1451 23 ) ) -RRB- cord-005453-4057qib7 1451 24 . . . cord-005453-4057qib7 1452 1 We -PRON- PRP cord-005453-4057qib7 1452 2 developed develop VBD cord-005453-4057qib7 1452 3 a a DT cord-005453-4057qib7 1452 4 new new JJ cord-005453-4057qib7 1452 5 CliniMACS CliniMACS NNP cord-005453-4057qib7 1452 6 Prodigy Prodigy NNP cord-005453-4057qib7 1452 7 ® ® NN cord-005453-4057qib7 1452 8 process process NN cord-005453-4057qib7 1452 9 in in IN cord-005453-4057qib7 1452 10 order order NN cord-005453-4057qib7 1452 11 to to TO cord-005453-4057qib7 1452 12 ease ease VB cord-005453-4057qib7 1452 13 the the DT cord-005453-4057qib7 1452 14 procedure procedure NN cord-005453-4057qib7 1452 15 for for IN cord-005453-4057qib7 1452 16 routine routine JJ cord-005453-4057qib7 1452 17 - - HYPH cord-005453-4057qib7 1452 18 use use NN cord-005453-4057qib7 1452 19 , , , cord-005453-4057qib7 1452 20 to to TO cord-005453-4057qib7 1452 21 reduce reduce VB cord-005453-4057qib7 1452 22 the the DT cord-005453-4057qib7 1452 23 specifications specification NNS cord-005453-4057qib7 1452 24 according accord VBG cord-005453-4057qib7 1452 25 to to IN cord-005453-4057qib7 1452 26 reported report VBN cord-005453-4057qib7 1452 27 cell cell NN cord-005453-4057qib7 1452 28 numbers number NNS cord-005453-4057qib7 1452 29 for for IN cord-005453-4057qib7 1452 30 DLI DLI NNP cord-005453-4057qib7 1452 31 applications application NNS cord-005453-4057qib7 1452 32 , , , cord-005453-4057qib7 1452 33 and and CC cord-005453-4057qib7 1452 34 to to TO cord-005453-4057qib7 1452 35 enable enable VB cord-005453-4057qib7 1452 36 the the DT cord-005453-4057qib7 1452 37 use use NN cord-005453-4057qib7 1452 38 of of IN cord-005453-4057qib7 1452 39 peripheral peripheral JJ cord-005453-4057qib7 1452 40 blood blood NN cord-005453-4057qib7 1452 41 products product NNS cord-005453-4057qib7 1452 42 with with IN cord-005453-4057qib7 1452 43 high high JJ cord-005453-4057qib7 1452 44 amounts amount NNS cord-005453-4057qib7 1452 45 of of IN cord-005453-4057qib7 1452 46 red red JJ cord-005453-4057qib7 1452 47 blood blood NN cord-005453-4057qib7 1452 48 cells cell NNS cord-005453-4057qib7 1452 49 ( ( -LRB- cord-005453-4057qib7 1452 50 RBC RBC NNP cord-005453-4057qib7 1452 51 ) ) -RRB- cord-005453-4057qib7 1452 52 . . . cord-005453-4057qib7 1453 1 The the DT cord-005453-4057qib7 1453 2 new new JJ cord-005453-4057qib7 1453 3 system system NN cord-005453-4057qib7 1453 4 was be VBD cord-005453-4057qib7 1453 5 tested test VBN cord-005453-4057qib7 1453 6 by by IN cord-005453-4057qib7 1453 7 performance performance NN cord-005453-4057qib7 1453 8 runs run NNS cord-005453-4057qib7 1453 9 . . . cord-005453-4057qib7 1454 1 An an DT cord-005453-4057qib7 1454 2 new new JJ cord-005453-4057qib7 1454 3 fluorescent fluorescent JJ cord-005453-4057qib7 1454 4 flow flow NN cord-005453-4057qib7 1454 5 analysis analysis NN cord-005453-4057qib7 1454 6 protocol protocol NN cord-005453-4057qib7 1454 7 was be VBD cord-005453-4057qib7 1454 8 developed develop VBN cord-005453-4057qib7 1454 9 . . . cord-005453-4057qib7 1455 1 Results result NNS cord-005453-4057qib7 1455 2 : : : cord-005453-4057qib7 1456 1 The the DT cord-005453-4057qib7 1456 2 resulting result VBG cord-005453-4057qib7 1456 3 CliniMACS CliniMACS NNP cord-005453-4057qib7 1456 4 Prodigy Prodigy NNP cord-005453-4057qib7 1456 5 PB-45RA PB-45RA NNP cord-005453-4057qib7 1456 6 System System NNP cord-005453-4057qib7 1456 7 is be VBZ cord-005453-4057qib7 1456 8 an an DT cord-005453-4057qib7 1456 9 automated automate VBN cord-005453-4057qib7 1456 10 procedure procedure NN cord-005453-4057qib7 1456 11 with with IN cord-005453-4057qib7 1456 12 integrated integrated JJ cord-005453-4057qib7 1456 13 labeling labeling NN cord-005453-4057qib7 1456 14 and and CC cord-005453-4057qib7 1456 15 washing washing NN cord-005453-4057qib7 1456 16 steps step NNS cord-005453-4057qib7 1456 17 . . . cord-005453-4057qib7 1457 1 The the DT cord-005453-4057qib7 1457 2 new new JJ cord-005453-4057qib7 1457 3 application application NN cord-005453-4057qib7 1457 4 software software NN cord-005453-4057qib7 1457 5 PB-45RA PB-45RA NNP cord-005453-4057qib7 1457 6 Depletion Depletion NNP cord-005453-4057qib7 1457 7 enables enable VBZ cord-005453-4057qib7 1457 8 to to TO cord-005453-4057qib7 1457 9 deplete deplete VB cord-005453-4057qib7 1457 10 up up RP cord-005453-4057qib7 1457 11 to to IN cord-005453-4057qib7 1457 12 1.8x10e9 1.8x10e9 CD cord-005453-4057qib7 1457 13 CD45RA cd45ra NN cord-005453-4057qib7 1457 14 + + CC cord-005453-4057qib7 1457 15 cells cell NNS cord-005453-4057qib7 1457 16 from from IN cord-005453-4057qib7 1457 17 up up IN cord-005453-4057qib7 1457 18 to to IN cord-005453-4057qib7 1457 19 5x10e9 5x10e9 CD cord-005453-4057qib7 1457 20 total total NN cord-005453-4057qib7 1457 21 WBC WBC NNP cord-005453-4057qib7 1457 22 from from IN cord-005453-4057qib7 1457 23 peripheral peripheral JJ cord-005453-4057qib7 1457 24 blood blood NN cord-005453-4057qib7 1457 25 products product NNS cord-005453-4057qib7 1457 26 . . . cord-005453-4057qib7 1458 1 A a DT cord-005453-4057qib7 1458 2 major major JJ cord-005453-4057qib7 1458 3 difference difference NN cord-005453-4057qib7 1458 4 of of IN cord-005453-4057qib7 1458 5 this this DT cord-005453-4057qib7 1458 6 process process NN cord-005453-4057qib7 1458 7 is be VBZ cord-005453-4057qib7 1458 8 the the DT cord-005453-4057qib7 1458 9 RBC RBC NNP cord-005453-4057qib7 1458 10 removal removal NN cord-005453-4057qib7 1458 11 option option NN cord-005453-4057qib7 1458 12 based base VBN cord-005453-4057qib7 1458 13 on on IN cord-005453-4057qib7 1458 14 an an DT cord-005453-4057qib7 1458 15 integrated integrate VBN cord-005453-4057qib7 1458 16 camera camera NN cord-005453-4057qib7 1458 17 for for IN cord-005453-4057qib7 1458 18 cell cell NN cord-005453-4057qib7 1458 19 pellet pellet NN cord-005453-4057qib7 1458 20 detection detection NN cord-005453-4057qib7 1458 21 . . . cord-005453-4057qib7 1459 1 The the DT cord-005453-4057qib7 1459 2 final final JJ cord-005453-4057qib7 1459 3 cell cell NN cord-005453-4057qib7 1459 4 product product NN cord-005453-4057qib7 1459 5 is be VBZ cord-005453-4057qib7 1459 6 provided provide VBN cord-005453-4057qib7 1459 7 in in IN cord-005453-4057qib7 1459 8 physiologic physiologic JJ cord-005453-4057qib7 1459 9 saline saline NN cord-005453-4057qib7 1459 10 . . . cord-005453-4057qib7 1460 1 Verification verification NN cord-005453-4057qib7 1460 2 runs run VBZ cord-005453-4057qib7 1460 3 with with IN cord-005453-4057qib7 1460 4 peripheral peripheral JJ cord-005453-4057qib7 1460 5 blood blood NN cord-005453-4057qib7 1460 6 products product NNS cord-005453-4057qib7 1460 7 ( ( -LRB- cord-005453-4057qib7 1460 8 n=6 n=6 JJ cord-005453-4057qib7 1460 9 in in IN cord-005453-4057qib7 1460 10 total total JJ cord-005453-4057qib7 1460 11 , , , cord-005453-4057qib7 1460 12 n=3 n=3 NN cord-005453-4057qib7 1460 13 with with IN cord-005453-4057qib7 1460 14 whole whole JJ cord-005453-4057qib7 1460 15 blood blood NN cord-005453-4057qib7 1460 16 , , , cord-005453-4057qib7 1460 17 n=3 n=3 NN cord-005453-4057qib7 1460 18 with with IN cord-005453-4057qib7 1460 19 leukapheresis leukapheresis NN cord-005453-4057qib7 1460 20 products product NNS cord-005453-4057qib7 1460 21 ) ) -RRB- cord-005453-4057qib7 1460 22 resulted result VBD cord-005453-4057qib7 1460 23 in in IN cord-005453-4057qib7 1460 24 a a DT cord-005453-4057qib7 1460 25 mean mean JJ cord-005453-4057qib7 1460 26 depletion depletion NN cord-005453-4057qib7 1460 27 of of IN cord-005453-4057qib7 1460 28 5.0 5.0 CD cord-005453-4057qib7 1460 29 log log NN cord-005453-4057qib7 1460 30 ( ( -LRB- cord-005453-4057qib7 1460 31 range range VBP cord-005453-4057qib7 1460 32 3.9 3.9 CD cord-005453-4057qib7 1460 33 -5.7 -5.7 NFP cord-005453-4057qib7 1460 34 ) ) -RRB- cord-005453-4057qib7 1460 35 for for IN cord-005453-4057qib7 1460 36 CD45RA cd45ra NN cord-005453-4057qib7 1460 37 + + CC cord-005453-4057qib7 1460 38 T t NN cord-005453-4057qib7 1460 39 cells cell NNS cord-005453-4057qib7 1460 40 in in IN cord-005453-4057qib7 1460 41 the the DT cord-005453-4057qib7 1460 42 CD45RA cd45ra NN cord-005453-4057qib7 1460 43 depleted deplete VBN cord-005453-4057qib7 1460 44 product product NN cord-005453-4057qib7 1460 45 . . . cord-005453-4057qib7 1461 1 Viability viability NN cord-005453-4057qib7 1461 2 of of IN cord-005453-4057qib7 1461 3 the the DT cord-005453-4057qib7 1461 4 target target NN cord-005453-4057qib7 1461 5 products product NNS cord-005453-4057qib7 1461 6 was be VBD cord-005453-4057qib7 1461 7 always always RB cord-005453-4057qib7 1461 8 above above IN cord-005453-4057qib7 1461 9 96 96 CD cord-005453-4057qib7 1461 10 % % NN cord-005453-4057qib7 1461 11 , , , cord-005453-4057qib7 1461 12 and and CC cord-005453-4057qib7 1461 13 mean mean VB cord-005453-4057qib7 1461 14 WBC WBC NNP cord-005453-4057qib7 1461 15 recovery recovery NN cord-005453-4057qib7 1461 16 was be VBD cord-005453-4057qib7 1461 17 66 66 CD cord-005453-4057qib7 1461 18 % % NN cord-005453-4057qib7 1461 19 . . . cord-005453-4057qib7 1462 1 The the DT cord-005453-4057qib7 1462 2 mean mean JJ cord-005453-4057qib7 1462 3 process process NN cord-005453-4057qib7 1462 4 time time NN cord-005453-4057qib7 1462 5 was be VBD cord-005453-4057qib7 1462 6 3h23min 3h23min CD cord-005453-4057qib7 1463 1 ( ( -LRB- cord-005453-4057qib7 1463 2 range range NNP cord-005453-4057qib7 1463 3 3h 3h CD cord-005453-4057qib7 1463 4 to to IN cord-005453-4057qib7 1463 5 3h50min 3h50min CD cord-005453-4057qib7 1463 6 ) ) -RRB- cord-005453-4057qib7 1463 7 without without IN cord-005453-4057qib7 1463 8 including include VBG cord-005453-4057qib7 1463 9 the the DT cord-005453-4057qib7 1463 10 manual manual JJ cord-005453-4057qib7 1463 11 steps step NNS cord-005453-4057qib7 1463 12 , , , cord-005453-4057qib7 1463 13 i.e. i.e. FW cord-005453-4057qib7 1463 14 tubing tubing NN cord-005453-4057qib7 1463 15 set set VBN cord-005453-4057qib7 1463 16 installation installation NN cord-005453-4057qib7 1463 17 and and CC cord-005453-4057qib7 1463 18 downstream downstream JJ cord-005453-4057qib7 1463 19 analysis analysis NN cord-005453-4057qib7 1463 20 of of IN cord-005453-4057qib7 1463 21 blood blood NN cord-005453-4057qib7 1463 22 products product NNS cord-005453-4057qib7 1463 23 by by IN cord-005453-4057qib7 1463 24 flow flow NN cord-005453-4057qib7 1463 25 cytometry cytometry NN cord-005453-4057qib7 1463 26 . . . cord-005453-4057qib7 1464 1 This this DT cord-005453-4057qib7 1464 2 data datum NNS cord-005453-4057qib7 1464 3 were be VBD cord-005453-4057qib7 1464 4 in in IN cord-005453-4057qib7 1464 5 line line NN cord-005453-4057qib7 1464 6 with with IN cord-005453-4057qib7 1464 7 preceding precede VBG cord-005453-4057qib7 1464 8 evaluation evaluation NN cord-005453-4057qib7 1464 9 runs run NNS cord-005453-4057qib7 1464 10 ( ( -LRB- cord-005453-4057qib7 1464 11 n=6 n=6 NNP cord-005453-4057qib7 1464 12 ) ) -RRB- cord-005453-4057qib7 1464 13 , , , cord-005453-4057qib7 1464 14 and and CC cord-005453-4057qib7 1464 15 results result NNS cord-005453-4057qib7 1464 16 obtained obtain VBN cord-005453-4057qib7 1464 17 in in IN cord-005453-4057qib7 1464 18 cooperation cooperation NN cord-005453-4057qib7 1464 19 with with IN cord-005453-4057qib7 1464 20 an an DT cord-005453-4057qib7 1464 21 external external JJ cord-005453-4057qib7 1464 22 beta beta NN cord-005453-4057qib7 1464 23 test test NN cord-005453-4057qib7 1464 24 site site NN cord-005453-4057qib7 1464 25 . . . cord-005453-4057qib7 1465 1 3 3 LS cord-005453-4057qib7 1466 1 The the DT cord-005453-4057qib7 1466 2 performance performance NN cord-005453-4057qib7 1466 3 results result NNS cord-005453-4057qib7 1466 4 were be VBD cord-005453-4057qib7 1466 5 furthermore furthermore RB cord-005453-4057qib7 1466 6 in in IN cord-005453-4057qib7 1466 7 line line NN cord-005453-4057qib7 1466 8 with with IN cord-005453-4057qib7 1466 9 results result NNS cord-005453-4057qib7 1466 10 obtained obtain VBN cord-005453-4057qib7 1466 11 on on IN cord-005453-4057qib7 1466 12 CliniMACS CliniMACS NNP cord-005453-4057qib7 1466 13 Plus plus CC cord-005453-4057qib7 1466 14 instrument instrument NN cord-005453-4057qib7 1466 15 runs run VBZ cord-005453-4057qib7 1466 16 . . . cord-005453-4057qib7 1467 1 For for IN cord-005453-4057qib7 1467 2 quality quality NN cord-005453-4057qib7 1467 3 control control NN cord-005453-4057qib7 1467 4 of of IN cord-005453-4057qib7 1467 5 CD45RA cd45ra NN cord-005453-4057qib7 1467 6 depleted depleted JJ cord-005453-4057qib7 1467 7 products product NNS cord-005453-4057qib7 1467 8 we -PRON- PRP cord-005453-4057qib7 1467 9 developed develop VBD cord-005453-4057qib7 1467 10 a a DT cord-005453-4057qib7 1467 11 flow flow NN cord-005453-4057qib7 1467 12 cytometric cytometric NNP cord-005453-4057qib7 1467 13 analysis analysis NN cord-005453-4057qib7 1467 14 strategy strategy NN cord-005453-4057qib7 1467 15 for for IN cord-005453-4057qib7 1467 16 fast fast JJ cord-005453-4057qib7 1467 17 , , , cord-005453-4057qib7 1467 18 accurate accurate JJ cord-005453-4057qib7 1467 19 , , , cord-005453-4057qib7 1467 20 and and CC cord-005453-4057qib7 1467 21 convenient convenient JJ cord-005453-4057qib7 1467 22 analysis analysis NN cord-005453-4057qib7 1467 23 of of IN cord-005453-4057qib7 1467 24 even even RB cord-005453-4057qib7 1467 25 rare rare JJ cord-005453-4057qib7 1467 26 counts count NNS cord-005453-4057qib7 1467 27 of of IN cord-005453-4057qib7 1467 28 remaining remain VBG cord-005453-4057qib7 1467 29 unwanted unwanted JJ cord-005453-4057qib7 1467 30 cells cell NNS cord-005453-4057qib7 1467 31 . . . cord-005453-4057qib7 1468 1 It -PRON- PRP cord-005453-4057qib7 1468 2 allows allow VBZ cord-005453-4057qib7 1468 3 to to TO cord-005453-4057qib7 1468 4 determine determine VB cord-005453-4057qib7 1468 5 naïve naïve JJ cord-005453-4057qib7 1468 6 T t NN cord-005453-4057qib7 1468 7 cells cell NNS cord-005453-4057qib7 1468 8 at at IN cord-005453-4057qib7 1468 9 two two CD cord-005453-4057qib7 1468 10 different different JJ cord-005453-4057qib7 1468 11 levels level NNS cord-005453-4057qib7 1468 12 of of IN cord-005453-4057qib7 1468 13 subset subset JJ cord-005453-4057qib7 1468 14 staining staining NN cord-005453-4057qib7 1468 15 . . . cord-005453-4057qib7 1469 1 The the DT cord-005453-4057qib7 1469 2 minimum minimum JJ cord-005453-4057qib7 1469 3 requirement requirement NN cord-005453-4057qib7 1469 4 for for IN cord-005453-4057qib7 1469 5 the the DT cord-005453-4057qib7 1469 6 flow flow NN cord-005453-4057qib7 1469 7 cytometric cytometric NNP cord-005453-4057qib7 1469 8 analysis analysis NN cord-005453-4057qib7 1469 9 includes include VBZ cord-005453-4057qib7 1469 10 4 4 CD cord-005453-4057qib7 1469 11 colors color NNS cord-005453-4057qib7 1469 12 to to TO cord-005453-4057qib7 1469 13 define define VB cord-005453-4057qib7 1469 14 viable viable JJ cord-005453-4057qib7 1469 15 CD3+CD45RA+ cd3+cd45ra+ NN cord-005453-4057qib7 1469 16 cells cell NNS cord-005453-4057qib7 1469 17 . . . cord-005453-4057qib7 1470 1 For for IN cord-005453-4057qib7 1470 2 further further JJ cord-005453-4057qib7 1470 3 evaluation evaluation NN cord-005453-4057qib7 1470 4 of of IN cord-005453-4057qib7 1470 5 the the DT cord-005453-4057qib7 1470 6 naïve naïve JJ cord-005453-4057qib7 1470 7 T T NNP cord-005453-4057qib7 1470 8 cell cell NN cord-005453-4057qib7 1470 9 subsets subset NNS cord-005453-4057qib7 1470 10 3 3 CD cord-005453-4057qib7 1470 11 additional additional JJ cord-005453-4057qib7 1470 12 colors color NNS cord-005453-4057qib7 1470 13 are be VBP cord-005453-4057qib7 1470 14 used use VBN cord-005453-4057qib7 1470 15 to to TO cord-005453-4057qib7 1470 16 define define VB cord-005453-4057qib7 1470 17 viable viable JJ cord-005453-4057qib7 1470 18 CD3+CD45RO cd3+cd45ro NN cord-005453-4057qib7 1470 19 - - HYPH cord-005453-4057qib7 1470 20 CD95-CD62L+CD197 cd95-cd62l+cd197 NN cord-005453-4057qib7 1470 21 + + CC cord-005453-4057qib7 1470 22 cells cell NNS cord-005453-4057qib7 1470 23 . . . cord-005453-4057qib7 1471 1 Conclusions conclusion NNS cord-005453-4057qib7 1471 2 : : : cord-005453-4057qib7 1472 1 The the DT cord-005453-4057qib7 1472 2 automated automated JJ cord-005453-4057qib7 1472 3 CliniMACS CliniMACS NNP cord-005453-4057qib7 1472 4 Prodigy Prodigy NNP cord-005453-4057qib7 1472 5 PB-45RA PB-45RA NNP cord-005453-4057qib7 1472 6 System System NNP cord-005453-4057qib7 1472 7 process process NN cord-005453-4057qib7 1472 8 is be VBZ cord-005453-4057qib7 1472 9 capable capable JJ cord-005453-4057qib7 1472 10 to to TO cord-005453-4057qib7 1472 11 deplete deplete VB cord-005453-4057qib7 1472 12 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 1472 13 cells cell NNS cord-005453-4057qib7 1472 14 efficiently efficiently RB cord-005453-4057qib7 1472 15 from from IN cord-005453-4057qib7 1472 16 peripheral peripheral JJ cord-005453-4057qib7 1472 17 blood blood NN cord-005453-4057qib7 1472 18 products product NNS cord-005453-4057qib7 1472 19 within within IN cord-005453-4057qib7 1472 20 4 4 CD cord-005453-4057qib7 1472 21 hours hour NNS cord-005453-4057qib7 1472 22 . . . cord-005453-4057qib7 1473 1 The the DT cord-005453-4057qib7 1473 2 new new JJ cord-005453-4057qib7 1473 3 process process NN cord-005453-4057qib7 1473 4 is be VBZ cord-005453-4057qib7 1473 5 a a DT cord-005453-4057qib7 1473 6 fast fast JJ cord-005453-4057qib7 1473 7 , , , cord-005453-4057qib7 1473 8 convenient convenient JJ cord-005453-4057qib7 1473 9 , , , cord-005453-4057qib7 1473 10 and and CC cord-005453-4057qib7 1473 11 regulatory regulatory JJ cord-005453-4057qib7 1473 12 compliant compliant JJ cord-005453-4057qib7 1473 13 method method NN cord-005453-4057qib7 1473 14 for for IN cord-005453-4057qib7 1473 15 the the DT cord-005453-4057qib7 1473 16 preparation preparation NN cord-005453-4057qib7 1473 17 of of IN cord-005453-4057qib7 1473 18 ready ready JJ cord-005453-4057qib7 1473 19 - - HYPH cord-005453-4057qib7 1473 20 to to IN cord-005453-4057qib7 1473 21 - - HYPH cord-005453-4057qib7 1473 22 use use NN cord-005453-4057qib7 1473 23 CD45RA cd45ra NN cord-005453-4057qib7 1473 24 - - HYPH cord-005453-4057qib7 1473 25 depleted deplete VBN cord-005453-4057qib7 1473 26 cell cell NN cord-005453-4057qib7 1473 27 products product NNS cord-005453-4057qib7 1473 28 for for IN cord-005453-4057qib7 1473 29 clinical clinical JJ cord-005453-4057qib7 1473 30 applications application NNS cord-005453-4057qib7 1473 31 . . . cord-005453-4057qib7 1474 1 The the DT cord-005453-4057qib7 1474 2 submission submission NN cord-005453-4057qib7 1474 3 to to IN cord-005453-4057qib7 1474 4 an an DT cord-005453-4057qib7 1474 5 European European NNP cord-005453-4057qib7 1474 6 notified notify VBN cord-005453-4057qib7 1474 7 body body NN cord-005453-4057qib7 1474 8 for for IN cord-005453-4057qib7 1474 9 CE CE NNP cord-005453-4057qib7 1474 10 certification certification NN cord-005453-4057qib7 1474 11 is be VBZ cord-005453-4057qib7 1474 12 an an DT cord-005453-4057qib7 1474 13 important important JJ cord-005453-4057qib7 1474 14 next next JJ cord-005453-4057qib7 1474 15 step step NN cord-005453-4057qib7 1474 16 . . . cord-005453-4057qib7 1475 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 1475 2 conditioning conditioning NN cord-005453-4057qib7 1475 3 regimen regimen NN cord-005453-4057qib7 1475 4 was be VBD cord-005453-4057qib7 1475 5 preferred prefer VBN cord-005453-4057qib7 1475 6 for for IN cord-005453-4057qib7 1475 7 24 24 CD cord-005453-4057qib7 1475 8 patients patient NNS cord-005453-4057qib7 1475 9 out out IN cord-005453-4057qib7 1475 10 of of IN cord-005453-4057qib7 1475 11 25 25 CD cord-005453-4057qib7 1475 12 . . . cord-005453-4057qib7 1476 1 GVHD GVHD NNP cord-005453-4057qib7 1476 2 prophylaxis prophylaxis NN cord-005453-4057qib7 1476 3 regimens regimen NNS cord-005453-4057qib7 1476 4 are be VBP cord-005453-4057qib7 1476 5 CSA CSA NNP cord-005453-4057qib7 1476 6 + + CC cord-005453-4057qib7 1476 7 MTX MTX NNP cord-005453-4057qib7 1476 8 : : : cord-005453-4057qib7 1476 9 20(%80 20(%80 CD cord-005453-4057qib7 1476 10 ) ) -RRB- cord-005453-4057qib7 1476 11 , , , cord-005453-4057qib7 1476 12 CSA+MMF CSA+MMF NNP cord-005453-4057qib7 1476 13 : : : cord-005453-4057qib7 1477 1 2(%8 2(%8 LS cord-005453-4057qib7 1477 2 ) ) -RRB- cord-005453-4057qib7 1477 3 , , , cord-005453-4057qib7 1477 4 CSA CSA NNP cord-005453-4057qib7 1477 5 only only RB cord-005453-4057qib7 1477 6 : : : cord-005453-4057qib7 1477 7 1(%4 1(%4 LS cord-005453-4057qib7 1477 8 ) ) -RRB- cord-005453-4057qib7 1477 9 . . . cord-005453-4057qib7 1478 1 ATG ATG NNP cord-005453-4057qib7 1478 2 was be VBD cord-005453-4057qib7 1478 3 given give VBN cord-005453-4057qib7 1478 4 20 20 CD cord-005453-4057qib7 1478 5 patients patient NNS cord-005453-4057qib7 1478 6 . . . cord-005453-4057qib7 1479 1 Despite despite IN cord-005453-4057qib7 1479 2 been be VBN cord-005453-4057qib7 1479 3 given give VBN cord-005453-4057qib7 1480 1 GVHD GVHD NNP cord-005453-4057qib7 1480 2 prophylaxis prophylaxis NN cord-005453-4057qib7 1480 3 47(%27,1 47(%27,1 CD cord-005453-4057qib7 1480 4 ) ) -RRB- cord-005453-4057qib7 1480 5 patients patient NNS cord-005453-4057qib7 1480 6 out out IN cord-005453-4057qib7 1480 7 of of IN cord-005453-4057qib7 1480 8 173 173 CD cord-005453-4057qib7 1480 9 transplanted transplant VBN cord-005453-4057qib7 1480 10 patients patient NNS cord-005453-4057qib7 1480 11 had have VBD cord-005453-4057qib7 1480 12 GVHD GVHD NNP cord-005453-4057qib7 1480 13 features feature NNS cord-005453-4057qib7 1480 14 . . . cord-005453-4057qib7 1481 1 Of of IN cord-005453-4057qib7 1481 2 47 47 CD cord-005453-4057qib7 1481 3 patients patient NNS cord-005453-4057qib7 1481 4 , , , cord-005453-4057qib7 1481 5 25 25 CD cord-005453-4057qib7 1481 6 had have VBD cord-005453-4057qib7 1481 7 experienced experience VBN cord-005453-4057qib7 1481 8 steroid steroid NN cord-005453-4057qib7 1481 9 resistant resistant JJ cord-005453-4057qib7 1481 10 GVHD GVHD NNP cord-005453-4057qib7 1481 11 after after IN cord-005453-4057qib7 1481 12 transplantation transplantation NN cord-005453-4057qib7 1481 13 , , , cord-005453-4057qib7 1481 14 including include VBG cord-005453-4057qib7 1481 15 17 17 CD cord-005453-4057qib7 1481 16 ( ( -LRB- cord-005453-4057qib7 1481 17 % % NN cord-005453-4057qib7 1481 18 68 68 CD cord-005453-4057qib7 1481 19 ) ) -RRB- cord-005453-4057qib7 1481 20 grade grade NN cord-005453-4057qib7 1481 21 3 3 CD cord-005453-4057qib7 1481 22 and and CC cord-005453-4057qib7 1481 23 8 8 CD cord-005453-4057qib7 1481 24 ( ( -LRB- cord-005453-4057qib7 1481 25 % % NN cord-005453-4057qib7 1481 26 32 32 CD cord-005453-4057qib7 1481 27 ) ) -RRB- cord-005453-4057qib7 1481 28 grade grade NN cord-005453-4057qib7 1481 29 4 4 CD cord-005453-4057qib7 1481 30 . . . cord-005453-4057qib7 1482 1 ECP ECP NNP cord-005453-4057qib7 1482 2 treatment treatment NN cord-005453-4057qib7 1482 3 was be VBD cord-005453-4057qib7 1482 4 started start VBN cord-005453-4057qib7 1482 5 mean mean JJ cord-005453-4057qib7 1482 6 11 11 CD cord-005453-4057qib7 1482 7 days day NNS cord-005453-4057qib7 1482 8 after after IN cord-005453-4057qib7 1482 9 diagnosis diagnosis NN cord-005453-4057qib7 1482 10 of of IN cord-005453-4057qib7 1482 11 steroid steroid NN cord-005453-4057qib7 1482 12 resistant resistant JJ cord-005453-4057qib7 1482 13 GVHD GVHD NNP cord-005453-4057qib7 1482 14 and and CC cord-005453-4057qib7 1482 15 2 2 CD cord-005453-4057qib7 1482 16 ( ( -LRB- cord-005453-4057qib7 1482 17 % % NN cord-005453-4057qib7 1482 18 8 8 CD cord-005453-4057qib7 1482 19 ) ) -RRB- cord-005453-4057qib7 1482 20 patients patient NNS cord-005453-4057qib7 1482 21 had have VBD cord-005453-4057qib7 1482 22 complete complete JJ cord-005453-4057qib7 1482 23 response response NN cord-005453-4057qib7 1482 24 while while IN cord-005453-4057qib7 1482 25 12 12 CD cord-005453-4057qib7 1482 26 ( ( -LRB- cord-005453-4057qib7 1482 27 % % NN cord-005453-4057qib7 1482 28 48 48 CD cord-005453-4057qib7 1482 29 ) ) -RRB- cord-005453-4057qib7 1482 30 patients patient NNS cord-005453-4057qib7 1482 31 had have VBD cord-005453-4057qib7 1482 32 partial partial JJ cord-005453-4057qib7 1482 33 and and CC cord-005453-4057qib7 1482 34 11 11 CD cord-005453-4057qib7 1482 35 ( ( -LRB- cord-005453-4057qib7 1482 36 % % NN cord-005453-4057qib7 1482 37 44 44 CD cord-005453-4057qib7 1482 38 ) ) -RRB- cord-005453-4057qib7 1483 1 patients patient NNS cord-005453-4057qib7 1483 2 had have VBD cord-005453-4057qib7 1483 3 no no DT cord-005453-4057qib7 1483 4 response response NN cord-005453-4057qib7 1483 5 to to IN cord-005453-4057qib7 1483 6 ECP ECP NNP cord-005453-4057qib7 1483 7 treatment treatment NN cord-005453-4057qib7 1483 8 on on IN cord-005453-4057qib7 1483 9 day day NN cord-005453-4057qib7 1483 10 28 28 CD cord-005453-4057qib7 1483 11 . . . cord-005453-4057qib7 1484 1 Sixteen sixteen CD cord-005453-4057qib7 1484 2 out out IN cord-005453-4057qib7 1484 3 of of IN cord-005453-4057qib7 1484 4 25 25 CD cord-005453-4057qib7 1484 5 patients patient NNS cord-005453-4057qib7 1484 6 had have VBD cord-005453-4057qib7 1484 7 also also RB cord-005453-4057qib7 1484 8 received receive VBN cord-005453-4057qib7 1484 9 mesenchymal mesenchymal JJ cord-005453-4057qib7 1484 10 stem stem NN cord-005453-4057qib7 1484 11 cell cell NN cord-005453-4057qib7 1484 12 therapy therapy NN cord-005453-4057qib7 1484 13 as as IN cord-005453-4057qib7 1484 14 salvage salvage NN cord-005453-4057qib7 1484 15 therapy therapy NN cord-005453-4057qib7 1484 16 . . . cord-005453-4057qib7 1485 1 Only only RB cord-005453-4057qib7 1485 2 one one CD cord-005453-4057qib7 1485 3 patient patient NN cord-005453-4057qib7 1485 4 had have VBD cord-005453-4057qib7 1485 5 experienced experience VBN cord-005453-4057qib7 1485 6 hypocalcemic hypocalcemic NNP cord-005453-4057qib7 1485 7 tetany tetany NN cord-005453-4057qib7 1485 8 , , , cord-005453-4057qib7 1485 9 a a DT cord-005453-4057qib7 1485 10 complication complication NN cord-005453-4057qib7 1485 11 of of IN cord-005453-4057qib7 1485 12 ECP ECP NNP cord-005453-4057qib7 1485 13 procedure procedure NN cord-005453-4057qib7 1485 14 . . . cord-005453-4057qib7 1486 1 Thirteen thirteen CD cord-005453-4057qib7 1486 2 patients patient NNS cord-005453-4057qib7 1486 3 had have VBD cord-005453-4057qib7 1486 4 died die VBN cord-005453-4057qib7 1486 5 and and CC cord-005453-4057qib7 1486 6 12 12 CD cord-005453-4057qib7 1486 7 were be VBD cord-005453-4057qib7 1486 8 directly directly RB cord-005453-4057qib7 1486 9 related relate VBN cord-005453-4057qib7 1486 10 with with IN cord-005453-4057qib7 1486 11 steroid steroid NN cord-005453-4057qib7 1486 12 resistant resistant JJ cord-005453-4057qib7 1486 13 GVHD GVHD NNP cord-005453-4057qib7 1486 14 . . . cord-005453-4057qib7 1487 1 Other other JJ cord-005453-4057qib7 1487 2 conditions condition NNS cord-005453-4057qib7 1487 3 like like IN cord-005453-4057qib7 1487 4 relapse relapse NN cord-005453-4057qib7 1487 5 of of IN cord-005453-4057qib7 1487 6 primary primary JJ cord-005453-4057qib7 1487 7 disease disease NN cord-005453-4057qib7 1487 8 or or CC cord-005453-4057qib7 1487 9 PRES PRES NNP cord-005453-4057qib7 1487 10 syndrome syndrome NN cord-005453-4057qib7 1487 11 also also RB cord-005453-4057qib7 1487 12 played play VBD cord-005453-4057qib7 1487 13 role role NN cord-005453-4057qib7 1487 14 in in IN cord-005453-4057qib7 1487 15 death death NN cord-005453-4057qib7 1487 16 . . . cord-005453-4057qib7 1488 1 Conclusions conclusion NNS cord-005453-4057qib7 1488 2 : : : cord-005453-4057qib7 1489 1 Extracorporeal extracorporeal JJ cord-005453-4057qib7 1489 2 photopheresis photopheresis NN cord-005453-4057qib7 1489 3 is be VBZ cord-005453-4057qib7 1489 4 a a DT cord-005453-4057qib7 1489 5 reliable reliable JJ cord-005453-4057qib7 1489 6 and and CC cord-005453-4057qib7 1489 7 effective effective JJ cord-005453-4057qib7 1489 8 second second JJ cord-005453-4057qib7 1489 9 line line NN cord-005453-4057qib7 1489 10 treatment treatment NN cord-005453-4057qib7 1489 11 modality modality NN cord-005453-4057qib7 1489 12 in in IN cord-005453-4057qib7 1489 13 steroid steroid NN cord-005453-4057qib7 1489 14 resistant resistant JJ cord-005453-4057qib7 1489 15 GVHD GVHD NNP cord-005453-4057qib7 1489 16 . . . cord-005453-4057qib7 1490 1 Starting start VBG cord-005453-4057qib7 1490 2 ECP ECP NNP cord-005453-4057qib7 1490 3 sessions session NNS cord-005453-4057qib7 1490 4 as as RB cord-005453-4057qib7 1490 5 soon soon RB cord-005453-4057qib7 1490 6 as as IN cord-005453-4057qib7 1490 7 GVHD GVHD NNP cord-005453-4057qib7 1490 8 symptoms symptom NNS cord-005453-4057qib7 1490 9 occur occur VBP cord-005453-4057qib7 1490 10 increases increase VBZ cord-005453-4057qib7 1490 11 its -PRON- PRP$ cord-005453-4057qib7 1490 12 effectivity effectivity NN cord-005453-4057qib7 1490 13 . . . cord-005453-4057qib7 1491 1 Mesenchymal Mesenchymal NNS cord-005453-4057qib7 1491 2 stem stem VBP cord-005453-4057qib7 1491 3 cell cell NN cord-005453-4057qib7 1491 4 administration administration NN cord-005453-4057qib7 1491 5 with with IN cord-005453-4057qib7 1491 6 ECP ECP NNP cord-005453-4057qib7 1491 7 for for IN cord-005453-4057qib7 1491 8 16 16 CD cord-005453-4057qib7 1491 9 ( ( -LRB- cord-005453-4057qib7 1491 10 % % NN cord-005453-4057qib7 1491 11 64 64 CD cord-005453-4057qib7 1491 12 ) ) -RRB- cord-005453-4057qib7 1491 13 patients patient NNS cord-005453-4057qib7 1491 14 limits limit VBZ cord-005453-4057qib7 1491 15 our -PRON- PRP$ cord-005453-4057qib7 1491 16 study study NN cord-005453-4057qib7 1491 17 to to TO cord-005453-4057qib7 1491 18 reach reach VB cord-005453-4057qib7 1491 19 o o NN cord-005453-4057qib7 1491 20 conclusion conclusion NN cord-005453-4057qib7 1491 21 for for IN cord-005453-4057qib7 1491 22 efficacy efficacy NN cord-005453-4057qib7 1491 23 of of IN cord-005453-4057qib7 1491 24 ECP ECP NNP cord-005453-4057qib7 1491 25 itself -PRON- PRP cord-005453-4057qib7 1491 26 . . . cord-005453-4057qib7 1492 1 Need need VB cord-005453-4057qib7 1492 2 for for IN cord-005453-4057qib7 1492 3 hemodialysis hemodialysis NN cord-005453-4057qib7 1492 4 catheters catheter NNS cord-005453-4057qib7 1492 5 , , , cord-005453-4057qib7 1492 6 the the DT cord-005453-4057qib7 1492 7 prolonged prolonged JJ cord-005453-4057qib7 1492 8 sessions session NNS cord-005453-4057qib7 1492 9 while while IN cord-005453-4057qib7 1492 10 adequate adequate JJ cord-005453-4057qib7 1492 11 flow flow NN cord-005453-4057qib7 1492 12 is be VBZ cord-005453-4057qib7 1492 13 not not RB cord-005453-4057qib7 1492 14 possible possible JJ cord-005453-4057qib7 1492 15 and and CC cord-005453-4057qib7 1492 16 catheter catheter NN cord-005453-4057qib7 1492 17 related related JJ cord-005453-4057qib7 1492 18 infections infection NNS cord-005453-4057qib7 1492 19 are be VBP cord-005453-4057qib7 1492 20 the the DT cord-005453-4057qib7 1492 21 lmitations lmitation NNS cord-005453-4057qib7 1492 22 for for IN cord-005453-4057qib7 1492 23 feasibility feasibility NN cord-005453-4057qib7 1492 24 of of IN cord-005453-4057qib7 1492 25 ECP ECP NNP cord-005453-4057qib7 1492 26 . . . cord-005453-4057qib7 1493 1 Disclosure disclosure NN cord-005453-4057qib7 1493 2 : : : cord-005453-4057qib7 1493 3 nothing nothing NN cord-005453-4057qib7 1493 4 to to TO cord-005453-4057qib7 1493 5 declare declare VB cord-005453-4057qib7 1493 6 Donor donor NN cord-005453-4057qib7 1493 7 lymphocyte lymphocyte NN cord-005453-4057qib7 1493 8 infusion infusion NN cord-005453-4057qib7 1493 9 administrations administration NNS cord-005453-4057qib7 1493 10 after after IN cord-005453-4057qib7 1493 11 allogeneic allogeneic NN cord-005453-4057qib7 1493 12 stem stem NN cord-005453-4057qib7 1493 13 cell cell NN cord-005453-4057qib7 1493 14 transplantations transplantation NNS cord-005453-4057qib7 1493 15 in in IN cord-005453-4057qib7 1493 16 pediatrics pediatric NNS cord-005453-4057qib7 1493 17 : : : cord-005453-4057qib7 1494 1 A a DT cord-005453-4057qib7 1494 2 single single JJ cord-005453-4057qib7 1494 3 center center NN cord-005453-4057qib7 1494 4 experience experience NN cord-005453-4057qib7 1495 1 Background background NN cord-005453-4057qib7 1495 2 : : : cord-005453-4057qib7 1496 1 Loss loss NN cord-005453-4057qib7 1496 2 of of IN cord-005453-4057qib7 1496 3 chimerism chimerism NN cord-005453-4057qib7 1496 4 is be VBZ cord-005453-4057qib7 1496 5 one one CD cord-005453-4057qib7 1496 6 of of IN cord-005453-4057qib7 1496 7 the the DT cord-005453-4057qib7 1496 8 major major JJ cord-005453-4057qib7 1496 9 problems problem NNS cord-005453-4057qib7 1496 10 after after IN cord-005453-4057qib7 1496 11 allogeneic allogeneic NN cord-005453-4057qib7 1496 12 stem stem NN cord-005453-4057qib7 1496 13 cell cell NN cord-005453-4057qib7 1496 14 transplantation(SCT transplantation(sct NN cord-005453-4057qib7 1496 15 ) ) -RRB- cord-005453-4057qib7 1496 16 . . . cord-005453-4057qib7 1497 1 Donor donor NN cord-005453-4057qib7 1497 2 - - HYPH cord-005453-4057qib7 1497 3 lymphocyte lymphocyte NN cord-005453-4057qib7 1497 4 infusions(DLI infusions(DLI NNS cord-005453-4057qib7 1497 5 ) ) -RRB- cord-005453-4057qib7 1497 6 are be VBP cord-005453-4057qib7 1497 7 used use VBN cord-005453-4057qib7 1497 8 as as IN cord-005453-4057qib7 1497 9 a a DT cord-005453-4057qib7 1497 10 treatment treatment NN cord-005453-4057qib7 1497 11 after after IN cord-005453-4057qib7 1497 12 taper taper NN cord-005453-4057qib7 1497 13 or or CC cord-005453-4057qib7 1497 14 stopping stop VBG cord-005453-4057qib7 1497 15 immunosuppression immunosuppression NN cord-005453-4057qib7 1497 16 . . . cord-005453-4057qib7 1498 1 In in IN cord-005453-4057qib7 1498 2 this this DT cord-005453-4057qib7 1498 3 study study NN cord-005453-4057qib7 1498 4 , , , cord-005453-4057qib7 1498 5 DLI DLI NNP cord-005453-4057qib7 1498 6 experience experience NN cord-005453-4057qib7 1498 7 in in IN cord-005453-4057qib7 1498 8 20 20 CD cord-005453-4057qib7 1498 9 patients patient NNS cord-005453-4057qib7 1498 10 with with IN cord-005453-4057qib7 1498 11 loss loss NN cord-005453-4057qib7 1498 12 of of IN cord-005453-4057qib7 1498 13 chimerism chimerism NN cord-005453-4057qib7 1498 14 after after IN cord-005453-4057qib7 1498 15 SCT SCT NNP cord-005453-4057qib7 1498 16 due due IN cord-005453-4057qib7 1498 17 to to IN cord-005453-4057qib7 1498 18 various various JJ cord-005453-4057qib7 1498 19 benign benign JJ cord-005453-4057qib7 1498 20 and and CC cord-005453-4057qib7 1498 21 malign malign JJ cord-005453-4057qib7 1498 22 hematological hematological JJ cord-005453-4057qib7 1498 23 diseases disease NNS cord-005453-4057qib7 1498 24 was be VBD cord-005453-4057qib7 1498 25 presented present VBN cord-005453-4057qib7 1498 26 . . . cord-005453-4057qib7 1499 1 Methods method NNS cord-005453-4057qib7 1499 2 : : : cord-005453-4057qib7 1499 3 Between between IN cord-005453-4057qib7 1499 4 July July NNP cord-005453-4057qib7 1499 5 2015-August 2015-august CD cord-005453-4057qib7 1499 6 2018 2018 CD cord-005453-4057qib7 1499 7 , , , cord-005453-4057qib7 1499 8 twenty twenty CD cord-005453-4057qib7 1499 9 patients patient NNS cord-005453-4057qib7 1499 10 , , , cord-005453-4057qib7 1499 11 detected detect VBD cord-005453-4057qib7 1499 12 chimerism chimerism NN cord-005453-4057qib7 1499 13 loss loss NN cord-005453-4057qib7 1499 14 and and CC cord-005453-4057qib7 1499 15 received receive VBD cord-005453-4057qib7 1499 16 DLI DLI NNP cord-005453-4057qib7 1499 17 after after IN cord-005453-4057qib7 1499 18 SCT SCT NNP cord-005453-4057qib7 1499 19 were be VBD cord-005453-4057qib7 1499 20 evaluated evaluate VBN cord-005453-4057qib7 1499 21 retrospectively retrospectively RB cord-005453-4057qib7 1499 22 . . . cord-005453-4057qib7 1500 1 Patients patient NNS cord-005453-4057qib7 1500 2 received receive VBD cord-005453-4057qib7 1500 3 myeloablative myeloablative JJ cord-005453-4057qib7 1500 4 or or CC cord-005453-4057qib7 1500 5 reduced reduced JJ cord-005453-4057qib7 1500 6 intensity intensity NN cord-005453-4057qib7 1500 7 conditioning conditioning NN cord-005453-4057qib7 1500 8 , , , cord-005453-4057qib7 1500 9 ATG ATG NNP cord-005453-4057qib7 1500 10 , , , cord-005453-4057qib7 1500 11 cyclosporine cyclosporine NN cord-005453-4057qib7 1500 12 A a NN cord-005453-4057qib7 1500 13 and and CC cord-005453-4057qib7 1500 14 methotrexate methotrexate NN cord-005453-4057qib7 1500 15 for for IN cord-005453-4057qib7 1500 16 GVHD GVHD NNP cord-005453-4057qib7 1500 17 prophylaxis prophylaxis NN cord-005453-4057qib7 1500 18 . . . cord-005453-4057qib7 1501 1 Chimerism chimerism NN cord-005453-4057qib7 1501 2 analyses analysis NNS cord-005453-4057qib7 1501 3 were be VBD cord-005453-4057qib7 1501 4 performed perform VBN cord-005453-4057qib7 1501 5 with with IN cord-005453-4057qib7 1501 6 short short JJ cord-005453-4057qib7 1501 7 tandem tandem NN cord-005453-4057qib7 1502 1 repeat(STR repeat(str LS cord-005453-4057qib7 1502 2 ) ) -RRB- cord-005453-4057qib7 1502 3 method method NN cord-005453-4057qib7 1502 4 from from IN cord-005453-4057qib7 1502 5 peripheral peripheral JJ cord-005453-4057qib7 1502 6 blood blood NN cord-005453-4057qib7 1502 7 . . . cord-005453-4057qib7 1503 1 Results result NNS cord-005453-4057qib7 1503 2 below below IN cord-005453-4057qib7 1503 3 95 95 CD cord-005453-4057qib7 1503 4 % % NN cord-005453-4057qib7 1503 5 were be VBD cord-005453-4057qib7 1503 6 considered consider VBN cord-005453-4057qib7 1503 7 as as RB cord-005453-4057qib7 1503 8 mixed mixed JJ cord-005453-4057qib7 1503 9 chimeric chimeric JJ cord-005453-4057qib7 1503 10 and and CC cord-005453-4057qib7 1503 11 below below IN cord-005453-4057qib7 1503 12 % % NN cord-005453-4057qib7 1503 13 5 5 CD cord-005453-4057qib7 1503 14 were be VBD cord-005453-4057qib7 1503 15 nonchimeric nonchimeric JJ cord-005453-4057qib7 1503 16 . . . cord-005453-4057qib7 1504 1 When when WRB cord-005453-4057qib7 1504 2 patients patient NNS cord-005453-4057qib7 1504 3 considered consider VBN cord-005453-4057qib7 1504 4 as as IN cord-005453-4057qib7 1504 5 mixed mixed JJ cord-005453-4057qib7 1504 6 chimeric chimeric JJ cord-005453-4057qib7 1504 7 , , , cord-005453-4057qib7 1504 8 immunosuppression immunosuppression NN cord-005453-4057qib7 1504 9 therapy therapy NN cord-005453-4057qib7 1504 10 was be VBD cord-005453-4057qib7 1504 11 ceased cease VBN cord-005453-4057qib7 1504 12 immediately immediately RB cord-005453-4057qib7 1504 13 and and CC cord-005453-4057qib7 1504 14 treated treat VBN cord-005453-4057qib7 1504 15 with with IN cord-005453-4057qib7 1504 16 DLI DLI NNP cord-005453-4057qib7 1504 17 . . . cord-005453-4057qib7 1505 1 Donor donor NN cord-005453-4057qib7 1505 2 lymphocyte lymphocyte NN cord-005453-4057qib7 1505 3 infusions infusion NNS cord-005453-4057qib7 1505 4 were be VBD cord-005453-4057qib7 1505 5 performed perform VBN cord-005453-4057qib7 1505 6 at at IN cord-005453-4057qib7 1505 7 two two CD cord-005453-4057qib7 1505 8 - - HYPH cord-005453-4057qib7 1505 9 week week NN cord-005453-4057qib7 1505 10 intervals interval NNS cord-005453-4057qib7 1505 11 with with IN cord-005453-4057qib7 1505 12 chimerism chimerism NN cord-005453-4057qib7 1505 13 follow follow NN cord-005453-4057qib7 1505 14 - - HYPH cord-005453-4057qib7 1505 15 up up NN cord-005453-4057qib7 1505 16 . . . cord-005453-4057qib7 1506 1 Student student NN cord-005453-4057qib7 1506 2 T T NNP cord-005453-4057qib7 1506 3 , , , cord-005453-4057qib7 1506 4 Mann Mann NNP cord-005453-4057qib7 1506 5 Whitney Whitney NNP cord-005453-4057qib7 1506 6 U U NNP cord-005453-4057qib7 1506 7 , , , cord-005453-4057qib7 1506 8 Ki Ki NNP cord-005453-4057qib7 1506 9 Kare Kare NNP cord-005453-4057qib7 1506 10 tests test VBZ cord-005453-4057qib7 1506 11 and and CC cord-005453-4057qib7 1506 12 Kaplan Kaplan NNP cord-005453-4057qib7 1506 13 - - HYPH cord-005453-4057qib7 1506 14 Meier Meier NNP cord-005453-4057qib7 1506 15 analysis analysis NN cord-005453-4057qib7 1506 16 were be VBD cord-005453-4057qib7 1506 17 used use VBN cord-005453-4057qib7 1506 18 . . . cord-005453-4057qib7 1507 1 Results result NNS cord-005453-4057qib7 1507 2 : : : cord-005453-4057qib7 1508 1 Between between IN cord-005453-4057qib7 1508 2 1 1 CD cord-005453-4057qib7 1508 3 - - SYM cord-005453-4057qib7 1508 4 16 16 CD cord-005453-4057qib7 1508 5 ages age NNS cord-005453-4057qib7 1508 6 ( ( -LRB- cord-005453-4057qib7 1508 7 median median NN cord-005453-4057qib7 1508 8 4 4 CD cord-005453-4057qib7 1508 9 ) ) -RRB- cord-005453-4057qib7 1508 10 , , , cord-005453-4057qib7 1508 11 7 7 CD cord-005453-4057qib7 1508 12 female female JJ cord-005453-4057qib7 1508 13 , , , cord-005453-4057qib7 1508 14 13 13 CD cord-005453-4057qib7 1508 15 male male JJ cord-005453-4057qib7 1508 16 patients patient NNS cord-005453-4057qib7 1508 17 were be VBD cord-005453-4057qib7 1508 18 evaluated evaluate VBN cord-005453-4057qib7 1508 19 . . . cord-005453-4057qib7 1509 1 The the DT cord-005453-4057qib7 1509 2 initial initial JJ cord-005453-4057qib7 1509 3 diagnoses diagnosis NNS cord-005453-4057qib7 1509 4 were be VBD cord-005453-4057qib7 1509 5 thalassemia thalassemia NN cord-005453-4057qib7 1509 6 major(10 major(10 NNP cord-005453-4057qib7 1509 7 ) ) -RRB- cord-005453-4057qib7 1509 8 , , , cord-005453-4057qib7 1509 9 aplastic aplastic JJ cord-005453-4057qib7 1509 10 anemia anemia NN cord-005453-4057qib7 1509 11 ( ( -LRB- cord-005453-4057qib7 1509 12 3),ALL(4 3),all(4 NN cord-005453-4057qib7 1509 13 ) ) -RRB- cord-005453-4057qib7 1509 14 , , , cord-005453-4057qib7 1509 15 AML AML NNP cord-005453-4057qib7 1509 16 ( ( -LRB- cord-005453-4057qib7 1509 17 3 3 CD cord-005453-4057qib7 1509 18 ) ) -RRB- cord-005453-4057qib7 1509 19 . . . cord-005453-4057qib7 1510 1 DLI DLI NNP cord-005453-4057qib7 1510 2 initiation initiation NN cord-005453-4057qib7 1510 3 time time NN cord-005453-4057qib7 1510 4 was be VBD cord-005453-4057qib7 1510 5 119.65 119.65 CD cord-005453-4057qib7 1510 6 + + SYM cord-005453-4057qib7 1510 7 -92.71 -92.71 NN cord-005453-4057qib7 1510 8 days day NNS cord-005453-4057qib7 1510 9 after after IN cord-005453-4057qib7 1510 10 SCT SCT NNP cord-005453-4057qib7 1510 11 , , , cord-005453-4057qib7 1510 12 total total JJ cord-005453-4057qib7 1510 13 number number NN cord-005453-4057qib7 1510 14 of of IN cord-005453-4057qib7 1510 15 DLI DLI NNP cord-005453-4057qib7 1510 16 administrations administration NNS cord-005453-4057qib7 1510 17 were be VBD cord-005453-4057qib7 1510 18 3.5 3.5 CD cord-005453-4057qib7 1510 19 + + CD cord-005453-4057qib7 1510 20 -2.19 -2.19 CD cord-005453-4057qib7 1510 21 . . . cord-005453-4057qib7 1511 1 Dose dose NN cord-005453-4057qib7 1511 2 of of IN cord-005453-4057qib7 1511 3 DLI DLI NNP cord-005453-4057qib7 1511 4 was be VBD cord-005453-4057qib7 1511 5 1X10 1x10 CD cord-005453-4057qib7 1511 6 5 5 CD cord-005453-4057qib7 1511 7 -63.6x10 -63.6x10 CD cord-005453-4057qib7 1511 8 6 6 CD cord-005453-4057qib7 1512 1 /kg /kg . cord-005453-4057qib7 1513 1 ( ( -LRB- cord-005453-4057qib7 1513 2 mean mean VB cord-005453-4057qib7 1513 3 20.5x10 20.5x10 CD cord-005453-4057qib7 1513 4 6 6 CD cord-005453-4057qib7 1513 5 /kg /kg . cord-005453-4057qib7 1513 6 ) ) -RRB- cord-005453-4057qib7 1513 7 . . . cord-005453-4057qib7 1514 1 Nine nine CD cord-005453-4057qib7 1514 2 patients patient NNS cord-005453-4057qib7 1514 3 ' ' POS cord-005453-4057qib7 1514 4 chimerism chimerism NN cord-005453-4057qib7 1514 5 out out IN cord-005453-4057qib7 1514 6 of of IN cord-005453-4057qib7 1514 7 20 20 CD cord-005453-4057qib7 1514 8 , , , cord-005453-4057qib7 1514 9 fell fall VBD cord-005453-4057qib7 1514 10 below below IN cord-005453-4057qib7 1514 11 95 95 CD cord-005453-4057qib7 1514 12 % % NN cord-005453-4057qib7 1514 13 at at IN cord-005453-4057qib7 1514 14 first first JJ cord-005453-4057qib7 1514 15 month month NN cord-005453-4057qib7 1514 16 after after IN cord-005453-4057qib7 1514 17 transplant transplant NN cord-005453-4057qib7 1514 18 ; ; : cord-005453-4057qib7 1514 19 4 4 CD cord-005453-4057qib7 1514 20 patients patient NNS cord-005453-4057qib7 1514 21 were be VBD cord-005453-4057qib7 1514 22 nonchimeric nonchimeric JJ cord-005453-4057qib7 1514 23 , , , cord-005453-4057qib7 1514 24 2 2 CD cord-005453-4057qib7 1514 25 of of IN cord-005453-4057qib7 1514 26 them -PRON- PRP cord-005453-4057qib7 1514 27 were be VBD cord-005453-4057qib7 1514 28 complet complet JJ cord-005453-4057qib7 1514 29 chimeric chimeric JJ cord-005453-4057qib7 1514 30 and and CC cord-005453-4057qib7 1514 31 3 3 CD cord-005453-4057qib7 1514 32 were be VBD cord-005453-4057qib7 1514 33 mixed mix VBN cord-005453-4057qib7 1514 34 chimeric chimeric JJ cord-005453-4057qib7 1514 35 . . . cord-005453-4057qib7 1515 1 Eleven eleven CD cord-005453-4057qib7 1515 2 patients´chimerism patients´chimerism NN cord-005453-4057qib7 1515 3 were be VBD cord-005453-4057qib7 1515 4 below below IN cord-005453-4057qib7 1515 5 95 95 CD cord-005453-4057qib7 1515 6 % % NN cord-005453-4057qib7 1515 7 between between IN cord-005453-4057qib7 1515 8 1 1 CD cord-005453-4057qib7 1515 9 - - SYM cord-005453-4057qib7 1515 10 6 6 CD cord-005453-4057qib7 1515 11 months month NNS cord-005453-4057qib7 1515 12 after after IN cord-005453-4057qib7 1515 13 SCT SCT NNP cord-005453-4057qib7 1515 14 , , , cord-005453-4057qib7 1515 15 5 5 CD cord-005453-4057qib7 1515 16 patients patient NNS cord-005453-4057qib7 1515 17 were be VBD cord-005453-4057qib7 1515 18 nonchimeric nonchimeric JJ cord-005453-4057qib7 1515 19 and and CC cord-005453-4057qib7 1515 20 6 6 CD cord-005453-4057qib7 1515 21 were be VBD cord-005453-4057qib7 1515 22 mixed mix VBN cord-005453-4057qib7 1515 23 chimeric chimeric JJ cord-005453-4057qib7 1515 24 . . . cord-005453-4057qib7 1516 1 Early early JJ cord-005453-4057qib7 1516 2 mixed mixed JJ cord-005453-4057qib7 1516 3 chimerism chimerism NN cord-005453-4057qib7 1516 4 was be VBD cord-005453-4057qib7 1516 5 found find VBN cord-005453-4057qib7 1516 6 relevant relevant JJ cord-005453-4057qib7 1516 7 with with IN cord-005453-4057qib7 1516 8 graft graft NN cord-005453-4057qib7 1516 9 rejections rejection NNS cord-005453-4057qib7 1516 10 ( ( -LRB- cord-005453-4057qib7 1516 11 p=0.04 p=0.04 NNP cord-005453-4057qib7 1516 12 ) ) -RRB- cord-005453-4057qib7 1516 13 . . . cord-005453-4057qib7 1517 1 Patients patient NNS cord-005453-4057qib7 1517 2 were be VBD cord-005453-4057qib7 1517 3 followed follow VBN cord-005453-4057qib7 1517 4 up up RP cord-005453-4057qib7 1517 5 for for IN cord-005453-4057qib7 1517 6 91 91 CD cord-005453-4057qib7 1517 7 - - SYM cord-005453-4057qib7 1517 8 645 645 CD cord-005453-4057qib7 1517 9 days day NNS cord-005453-4057qib7 1517 10 . . . cord-005453-4057qib7 1518 1 Eight eight CD cord-005453-4057qib7 1518 2 patients patient NNS cord-005453-4057qib7 1518 3 ' ' POS cord-005453-4057qib7 1518 4 chimerism chimerism NN cord-005453-4057qib7 1518 5 increased increase VBD cord-005453-4057qib7 1518 6 after after IN cord-005453-4057qib7 1518 7 DLI DLI NNP cord-005453-4057qib7 1518 8 infusion infusion NN cord-005453-4057qib7 1518 9 and and CC cord-005453-4057qib7 1518 10 continued continue VBD cord-005453-4057qib7 1518 11 to to TO cord-005453-4057qib7 1518 12 decrease decrease VB cord-005453-4057qib7 1518 13 in in IN cord-005453-4057qib7 1518 14 12 12 CD cord-005453-4057qib7 1518 15 patients patient NNS cord-005453-4057qib7 1518 16 . . . cord-005453-4057qib7 1519 1 After after IN cord-005453-4057qib7 1519 2 DLI DLI NNP cord-005453-4057qib7 1519 3 , , , cord-005453-4057qib7 1519 4 acute acute JJ cord-005453-4057qib7 1519 5 GVHD GVHD NNP cord-005453-4057qib7 1519 6 has have VBZ cord-005453-4057qib7 1519 7 been be VBN cord-005453-4057qib7 1519 8 seen see VBN cord-005453-4057qib7 1519 9 in in IN cord-005453-4057qib7 1519 10 both both DT cord-005453-4057qib7 1519 11 group group NN cord-005453-4057qib7 1519 12 . . . cord-005453-4057qib7 1520 1 The the DT cord-005453-4057qib7 1520 2 group group NN cord-005453-4057qib7 1520 3 with with IN cord-005453-4057qib7 1520 4 decreased decrease VBN cord-005453-4057qib7 1520 5 chimerism chimerism NN cord-005453-4057qib7 1520 6 after after IN cord-005453-4057qib7 1520 7 DLI DLI NNP cord-005453-4057qib7 1520 8 , , , cord-005453-4057qib7 1520 9 dose dose NN cord-005453-4057qib7 1520 10 was be VBD cord-005453-4057qib7 1520 11 mean mean JJ cord-005453-4057qib7 1520 12 12x10 12x10 CD cord-005453-4057qib7 1520 13 6 6 CD cord-005453-4057qib7 1520 14 ±23x10 ±23x10 CD cord-005453-4057qib7 1520 15 6 6 CD cord-005453-4057qib7 1521 1 /kg /kg NFP cord-005453-4057qib7 1521 2 while while IN cord-005453-4057qib7 1521 3 the the DT cord-005453-4057qib7 1521 4 group group NN cord-005453-4057qib7 1521 5 with with IN cord-005453-4057qib7 1521 6 increased increase VBN cord-005453-4057qib7 1521 7 chimerism chimerism NN cord-005453-4057qib7 1521 8 had have VBD cord-005453-4057qib7 1522 1 DLI DLI NNP cord-005453-4057qib7 1522 2 dose dose NN cord-005453-4057qib7 1522 3 mean mean JJ cord-005453-4057qib7 1523 1 22x10 22x10 CD cord-005453-4057qib7 1523 2 6 6 CD cord-005453-4057qib7 1523 3 ±19x10 ±19x10 CD cord-005453-4057qib7 1523 4 6 6 CD cord-005453-4057qib7 1524 1 /kg /kg NFP cord-005453-4057qib7 1524 2 . . . cord-005453-4057qib7 1525 1 Although although IN cord-005453-4057qib7 1525 2 the the DT cord-005453-4057qib7 1525 3 difference difference NN cord-005453-4057qib7 1525 4 was be VBD cord-005453-4057qib7 1525 5 not not RB cord-005453-4057qib7 1525 6 statistically statistically RB cord-005453-4057qib7 1525 7 significant significant JJ cord-005453-4057qib7 1525 8 , , , cord-005453-4057qib7 1525 9 numerical numerical JJ cord-005453-4057qib7 1525 10 value value NN cord-005453-4057qib7 1525 11 revealed reveal VBD cord-005453-4057qib7 1525 12 significantly significantly RB cord-005453-4057qib7 1525 13 different different JJ cord-005453-4057qib7 1525 14 . . . cord-005453-4057qib7 1526 1 Eventually10 eventually10 NN cord-005453-4057qib7 1526 2 patients patient NNS cord-005453-4057qib7 1526 3 out out IN cord-005453-4057qib7 1526 4 of of IN cord-005453-4057qib7 1526 5 20 20 CD cord-005453-4057qib7 1526 6 were be VBD cord-005453-4057qib7 1526 7 mixed mix VBN cord-005453-4057qib7 1526 8 chimeric chimeric JJ cord-005453-4057qib7 1526 9 , , , cord-005453-4057qib7 1526 10 6 6 CD cord-005453-4057qib7 1526 11 patients patient NNS cord-005453-4057qib7 1526 12 were be VBD cord-005453-4057qib7 1526 13 complete complete JJ cord-005453-4057qib7 1526 14 chimeric chimeric JJ cord-005453-4057qib7 1526 15 and and CC cord-005453-4057qib7 1526 16 4 4 CD cord-005453-4057qib7 1526 17 were be VBD cord-005453-4057qib7 1526 18 none none NN cord-005453-4057qib7 1526 19 . . . cord-005453-4057qib7 1527 1 In in IN cord-005453-4057qib7 1527 2 thalassemic thalassemic JJ cord-005453-4057qib7 1527 3 patients patient NNS cord-005453-4057qib7 1527 4 , , , cord-005453-4057qib7 1527 5 7 7 CD cord-005453-4057qib7 1527 6 patients patient NNS cord-005453-4057qib7 1527 7 with with IN cord-005453-4057qib7 1527 8 thalassemia thalassemia NN cord-005453-4057qib7 1527 9 - - HYPH cord-005453-4057qib7 1527 10 trait trait NN cord-005453-4057qib7 1527 11 donor donor NN cord-005453-4057qib7 1527 12 were be VBD cord-005453-4057qib7 1527 13 mixed mix VBN cord-005453-4057qib7 1527 14 chimeric chimeric JJ cord-005453-4057qib7 1527 15 , , , cord-005453-4057qib7 1527 16 In in IN cord-005453-4057qib7 1527 17 3 3 CD cord-005453-4057qib7 1527 18 patients patient NNS cord-005453-4057qib7 1527 19 whose whose WP$ cord-005453-4057qib7 1527 20 donors donor NNS cord-005453-4057qib7 1527 21 were be VBD cord-005453-4057qib7 1527 22 normal normal JJ cord-005453-4057qib7 1527 23 , , , cord-005453-4057qib7 1527 24 2 2 CD cord-005453-4057qib7 1527 25 of of IN cord-005453-4057qib7 1527 26 them -PRON- PRP cord-005453-4057qib7 1527 27 were be VBD cord-005453-4057qib7 1527 28 complete complete JJ cord-005453-4057qib7 1527 29 chimeric chimeric JJ cord-005453-4057qib7 1527 30 and and CC cord-005453-4057qib7 1527 31 one one CD cord-005453-4057qib7 1527 32 of of IN cord-005453-4057qib7 1527 33 them -PRON- PRP cord-005453-4057qib7 1527 34 was be VBD cord-005453-4057qib7 1527 35 nonchimeric nonchimeric JJ cord-005453-4057qib7 1527 36 . . . cord-005453-4057qib7 1528 1 The the DT cord-005453-4057qib7 1528 2 difference difference NN cord-005453-4057qib7 1528 3 was be VBD cord-005453-4057qib7 1528 4 significant significant JJ cord-005453-4057qib7 1528 5 ( ( -LRB- cord-005453-4057qib7 1528 6 p=0.02 p=0.02 NN cord-005453-4057qib7 1528 7 ) ) -RRB- cord-005453-4057qib7 1528 8 . . . cord-005453-4057qib7 1529 1 The the DT cord-005453-4057qib7 1529 2 CD34 CD34 NNP cord-005453-4057qib7 1529 3 infusion infusion NN cord-005453-4057qib7 1529 4 doses dose NNS cord-005453-4057qib7 1529 5 revealed reveal VBD cord-005453-4057qib7 1529 6 mean mean JJ cord-005453-4057qib7 1529 7 6.61 6.61 CD cord-005453-4057qib7 1529 8 ±5.06x10 ±5.06x10 NNS cord-005453-4057qib7 1529 9 6 6 CD cord-005453-4057qib7 1529 10 /kg /kg NN cord-005453-4057qib7 1529 11 in in IN cord-005453-4057qib7 1529 12 mixed mixed JJ cord-005453-4057qib7 1529 13 chimeric chimeric JJ cord-005453-4057qib7 1529 14 patients patient NNS cord-005453-4057qib7 1529 15 , , , cord-005453-4057qib7 1529 16 7.16±3.31x10 7.16±3.31x10 CD cord-005453-4057qib7 1529 17 6 6 CD cord-005453-4057qib7 1529 18 /kg /kg NFP cord-005453-4057qib7 1529 19 in in IN cord-005453-4057qib7 1529 20 complete complete JJ cord-005453-4057qib7 1529 21 chimeric chimeric JJ cord-005453-4057qib7 1529 22 patients patient NNS cord-005453-4057qib7 1529 23 and and CC cord-005453-4057qib7 1529 24 6.625±1.37x10 6.625±1.37x10 NN cord-005453-4057qib7 1529 25 6 6 CD cord-005453-4057qib7 1530 1 /kg /kg NFP cord-005453-4057qib7 1530 2 in in IN cord-005453-4057qib7 1530 3 the the DT cord-005453-4057qib7 1530 4 patients patient NNS cord-005453-4057qib7 1530 5 with with IN cord-005453-4057qib7 1530 6 loss loss NN cord-005453-4057qib7 1530 7 of of IN cord-005453-4057qib7 1530 8 chimerism chimerism NN cord-005453-4057qib7 1530 9 . . . cord-005453-4057qib7 1531 1 CD34 CD34 NNP cord-005453-4057qib7 1531 2 amount amount NN cord-005453-4057qib7 1531 3 was be VBD cord-005453-4057qib7 1531 4 seen see VBN cord-005453-4057qib7 1531 5 high high JJ cord-005453-4057qib7 1531 6 as as IN cord-005453-4057qib7 1531 7 numerical numerical JJ cord-005453-4057qib7 1531 8 value value NN cord-005453-4057qib7 1531 9 in in IN cord-005453-4057qib7 1531 10 complete complete JJ cord-005453-4057qib7 1531 11 chimerics chimeric NNS cord-005453-4057qib7 1531 12 but but CC cord-005453-4057qib7 1531 13 no no DT cord-005453-4057qib7 1531 14 statistical statistical JJ cord-005453-4057qib7 1531 15 significance significance NN cord-005453-4057qib7 1531 16 was be VBD cord-005453-4057qib7 1531 17 found find VBN cord-005453-4057qib7 1531 18 . . . cord-005453-4057qib7 1532 1 Overall overall JJ cord-005453-4057qib7 1532 2 survival survival NN cord-005453-4057qib7 1532 3 was be VBD cord-005453-4057qib7 1532 4 85 85 CD cord-005453-4057qib7 1532 5 % % NN cord-005453-4057qib7 1532 6 , , , cord-005453-4057qib7 1532 7 disease disease NN cord-005453-4057qib7 1532 8 - - HYPH cord-005453-4057qib7 1532 9 free free JJ cord-005453-4057qib7 1532 10 survival survival NN cord-005453-4057qib7 1532 11 was be VBD cord-005453-4057qib7 1532 12 25 25 CD cord-005453-4057qib7 1532 13 % % NN cord-005453-4057qib7 1532 14 . . . cord-005453-4057qib7 1533 1 Conclusions conclusion NNS cord-005453-4057qib7 1533 2 : : : cord-005453-4057qib7 1534 1 We -PRON- PRP cord-005453-4057qib7 1534 2 evaluated evaluate VBD cord-005453-4057qib7 1534 3 the the DT cord-005453-4057qib7 1534 4 efficacy efficacy NN cord-005453-4057qib7 1534 5 of of IN cord-005453-4057qib7 1534 6 DL DL NNP cord-005453-4057qib7 1534 7 for for IN cord-005453-4057qib7 1534 8 patients patient NNS cord-005453-4057qib7 1534 9 with with IN cord-005453-4057qib7 1534 10 mixed mixed JJ cord-005453-4057qib7 1534 11 chimerism chimerism NN cord-005453-4057qib7 1534 12 in in IN cord-005453-4057qib7 1534 13 our -PRON- PRP$ cord-005453-4057qib7 1534 14 patient patient JJ cord-005453-4057qib7 1534 15 group group NN cord-005453-4057qib7 1534 16 . . . cord-005453-4057qib7 1535 1 We -PRON- PRP cord-005453-4057qib7 1535 2 concluded conclude VBD cord-005453-4057qib7 1535 3 that that IN cord-005453-4057qib7 1535 4 chimerism chimerism NN cord-005453-4057qib7 1535 5 loss loss NN cord-005453-4057qib7 1535 6 in in IN cord-005453-4057qib7 1535 7 patients patient NNS cord-005453-4057qib7 1535 8 with with IN cord-005453-4057qib7 1535 9 early early JJ cord-005453-4057qib7 1535 10 decreased decreased JJ cord-005453-4057qib7 1535 11 chimerism chimerism NN cord-005453-4057qib7 1535 12 is be VBZ cord-005453-4057qib7 1535 13 similar similar JJ cord-005453-4057qib7 1535 14 to to IN cord-005453-4057qib7 1535 15 those those DT cord-005453-4057qib7 1535 16 in in IN cord-005453-4057qib7 1535 17 literature literature NN cord-005453-4057qib7 1535 18 in in IN cord-005453-4057qib7 1535 19 spite spite NN cord-005453-4057qib7 1535 20 if if IN cord-005453-4057qib7 1535 21 DLI DLI NNP cord-005453-4057qib7 1535 22 practices practice NNS cord-005453-4057qib7 1535 23 . . . cord-005453-4057qib7 1536 1 Dose dose NN cord-005453-4057qib7 1536 2 and and CC cord-005453-4057qib7 1536 3 application application NN cord-005453-4057qib7 1536 4 frequency frequency NN cord-005453-4057qib7 1536 5 were be VBD cord-005453-4057qib7 1536 6 greater great JJR cord-005453-4057qib7 1536 7 in in IN cord-005453-4057qib7 1536 8 patients patient NNS cord-005453-4057qib7 1536 9 with with IN cord-005453-4057qib7 1536 10 increased increase VBN cord-005453-4057qib7 1536 11 chimerism chimerism NN cord-005453-4057qib7 1536 12 . . . cord-005453-4057qib7 1537 1 The the DT cord-005453-4057qib7 1537 2 small small JJ cord-005453-4057qib7 1537 3 number number NN cord-005453-4057qib7 1537 4 and and CC cord-005453-4057qib7 1537 5 the the DT cord-005453-4057qib7 1537 6 heterogeneity heterogeneity NN cord-005453-4057qib7 1537 7 of of IN cord-005453-4057qib7 1537 8 the the DT cord-005453-4057qib7 1537 9 patients patient NNS cord-005453-4057qib7 1537 10 limited limit VBD cord-005453-4057qib7 1537 11 our -PRON- PRP$ cord-005453-4057qib7 1537 12 study study NN cord-005453-4057qib7 1537 13 . . . cord-005453-4057qib7 1538 1 In in IN cord-005453-4057qib7 1538 2 this this DT cord-005453-4057qib7 1538 3 regard regard NN cord-005453-4057qib7 1538 4 , , , cord-005453-4057qib7 1538 5 studies study NNS cord-005453-4057qib7 1538 6 with with IN cord-005453-4057qib7 1538 7 larger large JJR cord-005453-4057qib7 1538 8 series series NN cord-005453-4057qib7 1538 9 and and CC cord-005453-4057qib7 1538 10 homogeneous homogeneous JJ cord-005453-4057qib7 1538 11 groups group NNS cord-005453-4057qib7 1538 12 are be VBP cord-005453-4057qib7 1538 13 acquired acquire VBN cord-005453-4057qib7 1538 14 . . . cord-005453-4057qib7 1539 1 Disclosure disclosure NN cord-005453-4057qib7 1539 2 : : : cord-005453-4057qib7 1539 3 Nothing nothing NN cord-005453-4057qib7 1539 4 to to TO cord-005453-4057qib7 1539 5 declare declare VB cord-005453-4057qib7 1539 6 Phase phase NN cord-005453-4057qib7 1540 1 I -PRON- PRP cord-005453-4057qib7 1540 2 clinical clinical JJ cord-005453-4057qib7 1540 3 trial trial NN cord-005453-4057qib7 1540 4 of of IN cord-005453-4057qib7 1540 5 repeated repeat VBN cord-005453-4057qib7 1540 6 administrations administration NNS cord-005453-4057qib7 1540 7 of of IN cord-005453-4057qib7 1540 8 bone bone NN cord-005453-4057qib7 1540 9 - - HYPH cord-005453-4057qib7 1540 10 marrow marrow NN cord-005453-4057qib7 1540 11 derived derive VBN cord-005453-4057qib7 1540 12 mesenchymal mesenchymal JJ cord-005453-4057qib7 1540 13 stem stem NN cord-005453-4057qib7 1540 14 cells cell NNS cord-005453-4057qib7 1540 15 in in IN cord-005453-4057qib7 1540 16 steroid steroid JJ cord-005453-4057qib7 1540 17 - - HYPH cord-005453-4057qib7 1540 18 refractory refractory JJ cord-005453-4057qib7 1540 19 chronic chronic JJ cord-005453-4057qib7 1540 20 graft graft NN cord-005453-4057qib7 1540 21 - - HYPH cord-005453-4057qib7 1540 22 versus versus IN cord-005453-4057qib7 1540 23 - - HYPH cord-005453-4057qib7 1540 24 host host NN cord-005453-4057qib7 1540 25 disease disease NN cord-005453-4057qib7 1540 26 patients patient NNS cord-005453-4057qib7 1540 27 Nayoun Nayoun NNP cord-005453-4057qib7 1540 28 Kim Kim NNP cord-005453-4057qib7 1540 29 1 1 CD cord-005453-4057qib7 1540 30 , , , cord-005453-4057qib7 1540 31 Young Young NNP cord-005453-4057qib7 1540 32 - - HYPH cord-005453-4057qib7 1540 33 Woo Woo NNP cord-005453-4057qib7 1540 34 Jeon Jeon NNP cord-005453-4057qib7 1540 35 2 2 CD cord-005453-4057qib7 1540 36 , , , cord-005453-4057qib7 1540 37 Jae Jae NNP cord-005453-4057qib7 1540 38 - - HYPH cord-005453-4057qib7 1540 39 Deog Deog NNP cord-005453-4057qib7 1540 40 Jang Jang NNP cord-005453-4057qib7 1540 41 1 1 CD cord-005453-4057qib7 1540 42 , , , cord-005453-4057qib7 1540 43 Keon Keon NNP cord-005453-4057qib7 1540 44 - - HYPH cord-005453-4057qib7 1540 45 Il Il NNP cord-005453-4057qib7 1541 1 I -PRON- PRP cord-005453-4057qib7 1542 1 m m NNP cord-005453-4057qib7 1542 2 1 1 CD cord-005453-4057qib7 1542 3 , , , cord-005453-4057qib7 1542 4 Nak Nak NNP cord-005453-4057qib7 1542 5 - - HYPH cord-005453-4057qib7 1542 6 Gyun Gyun NNP cord-005453-4057qib7 1542 7 Chung Chung NNP cord-005453-4057qib7 1542 8 2 2 CD cord-005453-4057qib7 1542 9 , , , cord-005453-4057qib7 1542 10 Young Young NNP cord-005453-4057qib7 1542 11 - - HYPH cord-005453-4057qib7 1542 12 Sun Sun NNP cord-005453-4057qib7 1542 13 Nam Nam NNP cord-005453-4057qib7 1542 14 1 1 CD cord-005453-4057qib7 1542 15 , , , cord-005453-4057qib7 1542 16 Yunejin Yunejin NNP cord-005453-4057qib7 1542 17 Song Song NNP cord-005453-4057qib7 1542 18 1 1 CD cord-005453-4057qib7 1542 19 , , , cord-005453-4057qib7 1542 20 Jun Jun NNP cord-005453-4057qib7 1542 21 - - HYPH cord-005453-4057qib7 1542 22 Seok Seok NNP cord-005453-4057qib7 1542 23 Lee Lee NNP cord-005453-4057qib7 1542 24 1 1 CD cord-005453-4057qib7 1542 25 , , , cord-005453-4057qib7 1542 26 Seok Seok NNP cord-005453-4057qib7 1542 27 - - HYPH cord-005453-4057qib7 1542 28 Goo Goo NNP cord-005453-4057qib7 1542 29 Cho Cho NNP cord-005453-4057qib7 1542 30 ( ( -LRB- cord-005453-4057qib7 1542 31 cGHVD cghvd IN cord-005453-4057qib7 1542 32 ) ) -RRB- cord-005453-4057qib7 1542 33 is be VBZ cord-005453-4057qib7 1542 34 the the DT cord-005453-4057qib7 1542 35 most most RBS cord-005453-4057qib7 1542 36 common common JJ cord-005453-4057qib7 1542 37 long long JJ cord-005453-4057qib7 1542 38 - - HYPH cord-005453-4057qib7 1542 39 term term NN cord-005453-4057qib7 1542 40 complication complication NN cord-005453-4057qib7 1542 41 of of IN cord-005453-4057qib7 1542 42 allogenic allogenic JJ cord-005453-4057qib7 1542 43 hematopoietic hematopoietic JJ cord-005453-4057qib7 1542 44 stem stem NN cord-005453-4057qib7 1542 45 cell cell NN cord-005453-4057qib7 1542 46 transplantation transplantation NN cord-005453-4057qib7 1542 47 which which WDT cord-005453-4057qib7 1542 48 is be VBZ cord-005453-4057qib7 1542 49 associated associate VBN cord-005453-4057qib7 1542 50 with with IN cord-005453-4057qib7 1542 51 poor poor JJ cord-005453-4057qib7 1542 52 quality quality NN cord-005453-4057qib7 1542 53 of of IN cord-005453-4057qib7 1542 54 life life NN cord-005453-4057qib7 1542 55 and and CC cord-005453-4057qib7 1542 56 increased increase VBN cord-005453-4057qib7 1542 57 risk risk NN cord-005453-4057qib7 1542 58 of of IN cord-005453-4057qib7 1542 59 morbidity morbidity NN cord-005453-4057qib7 1542 60 and and CC cord-005453-4057qib7 1542 61 mortality mortality NN cord-005453-4057qib7 1542 62 . . . cord-005453-4057qib7 1543 1 Currently currently RB cord-005453-4057qib7 1543 2 , , , cord-005453-4057qib7 1543 3 there there EX cord-005453-4057qib7 1543 4 is be VBZ cord-005453-4057qib7 1543 5 no no DT cord-005453-4057qib7 1543 6 standardized standardized JJ cord-005453-4057qib7 1543 7 treatment treatment NN cord-005453-4057qib7 1543 8 available available JJ cord-005453-4057qib7 1543 9 for for IN cord-005453-4057qib7 1543 10 patients patient NNS cord-005453-4057qib7 1543 11 who who WP cord-005453-4057qib7 1543 12 do do VBP cord-005453-4057qib7 1543 13 not not RB cord-005453-4057qib7 1543 14 respond respond VB cord-005453-4057qib7 1543 15 to to IN cord-005453-4057qib7 1543 16 steroids steroid NNS cord-005453-4057qib7 1543 17 . . . cord-005453-4057qib7 1544 1 As as IN cord-005453-4057qib7 1544 2 an an DT cord-005453-4057qib7 1544 3 alternative alternative NN cord-005453-4057qib7 1544 4 to to IN cord-005453-4057qib7 1544 5 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 1544 6 drugs drug NNS cord-005453-4057qib7 1544 7 , , , cord-005453-4057qib7 1544 8 mesenchymal mesenchymal JJ cord-005453-4057qib7 1544 9 stem stem NN cord-005453-4057qib7 1544 10 cells cell NNS cord-005453-4057qib7 1544 11 ( ( -LRB- cord-005453-4057qib7 1544 12 MSCs msc NNS cord-005453-4057qib7 1544 13 ) ) -RRB- cord-005453-4057qib7 1544 14 have have VBP cord-005453-4057qib7 1544 15 been be VBN cord-005453-4057qib7 1544 16 used use VBN cord-005453-4057qib7 1544 17 to to TO cord-005453-4057qib7 1544 18 treat treat VB cord-005453-4057qib7 1544 19 and and CC cord-005453-4057qib7 1544 20 prevent prevent VB cord-005453-4057qib7 1544 21 steroidrefractory steroidrefractory NN cord-005453-4057qib7 1544 22 acute acute JJ cord-005453-4057qib7 1544 23 GVHD GVHD NNP cord-005453-4057qib7 1544 24 patients patient NNS cord-005453-4057qib7 1544 25 . . . cord-005453-4057qib7 1545 1 These these DT cord-005453-4057qib7 1545 2 studies study NNS cord-005453-4057qib7 1545 3 and and CC cord-005453-4057qib7 1545 4 reports report NNS cord-005453-4057qib7 1545 5 have have VBP cord-005453-4057qib7 1545 6 also also RB cord-005453-4057qib7 1545 7 provided provide VBN cord-005453-4057qib7 1545 8 a a DT cord-005453-4057qib7 1545 9 basis basis NN cord-005453-4057qib7 1545 10 for for IN cord-005453-4057qib7 1545 11 using use VBG cord-005453-4057qib7 1545 12 MSCs msc NNS cord-005453-4057qib7 1545 13 in in IN cord-005453-4057qib7 1545 14 steroid steroid NN cord-005453-4057qib7 1545 15 refractory refractory JJ cord-005453-4057qib7 1545 16 cGVHD cGVHD NNP cord-005453-4057qib7 1545 17 patients patient NNS cord-005453-4057qib7 1545 18 . . . cord-005453-4057qib7 1546 1 Methods method NNS cord-005453-4057qib7 1546 2 : : : cord-005453-4057qib7 1546 3 To to TO cord-005453-4057qib7 1546 4 evaluate evaluate VB cord-005453-4057qib7 1546 5 the the DT cord-005453-4057qib7 1546 6 safety safety NN cord-005453-4057qib7 1546 7 and and CC cord-005453-4057qib7 1546 8 efficacy efficacy NN cord-005453-4057qib7 1546 9 of of IN cord-005453-4057qib7 1546 10 repeatedinfusions repeatedinfusion NNS cord-005453-4057qib7 1546 11 of of IN cord-005453-4057qib7 1546 12 MSCs msc NNS cord-005453-4057qib7 1546 13 , , , cord-005453-4057qib7 1546 14 we -PRON- PRP cord-005453-4057qib7 1546 15 enrolled enrol VBD cord-005453-4057qib7 1546 16 ten ten CD cord-005453-4057qib7 1546 17 severe severe JJ cord-005453-4057qib7 1546 18 steroid steroid NN cord-005453-4057qib7 1546 19 - - HYPH cord-005453-4057qib7 1546 20 refractory refractory JJ cord-005453-4057qib7 1546 21 cGVHDs cGVHDs NNP cord-005453-4057qib7 1546 22 patients patient NNS cord-005453-4057qib7 1546 23 . . . cord-005453-4057qib7 1547 1 Steroid steroid NN cord-005453-4057qib7 1547 2 refractory refractory NN cord-005453-4057qib7 1547 3 was be VBD cord-005453-4057qib7 1547 4 defined define VBN cord-005453-4057qib7 1547 5 as as IN cord-005453-4057qib7 1547 6 either either CC cord-005453-4057qib7 1547 7 no no DT cord-005453-4057qib7 1547 8 response response NN cord-005453-4057qib7 1547 9 to to IN cord-005453-4057qib7 1547 10 steroids steroid NNS cord-005453-4057qib7 1547 11 lasting last VBG cord-005453-4057qib7 1547 12 at at RB cord-005453-4057qib7 1547 13 least least JJS cord-005453-4057qib7 1547 14 4 4 CD cord-005453-4057qib7 1547 15 weeks week NNS cord-005453-4057qib7 1547 16 or or CC cord-005453-4057qib7 1547 17 progression progression NN cord-005453-4057qib7 1547 18 of of IN cord-005453-4057qib7 1547 19 disease disease NN cord-005453-4057qib7 1547 20 during during IN cord-005453-4057qib7 1547 21 treatment treatment NN cord-005453-4057qib7 1547 22 or or CC cord-005453-4057qib7 1547 23 tapering taper VBG cord-005453-4057qib7 1547 24 lasting last VBG cord-005453-4057qib7 1547 25 at at RB cord-005453-4057qib7 1547 26 least least JJS cord-005453-4057qib7 1547 27 2 2 CD cord-005453-4057qib7 1547 28 weeks week NNS cord-005453-4057qib7 1547 29 . . . cord-005453-4057qib7 1548 1 Patients patient NNS cord-005453-4057qib7 1548 2 were be VBD cord-005453-4057qib7 1548 3 intravenously intravenously RB cord-005453-4057qib7 1548 4 administered administer VBN cord-005453-4057qib7 1548 5 with with IN cord-005453-4057qib7 1548 6 MSCs msc NNS cord-005453-4057qib7 1548 7 produced produce VBN cord-005453-4057qib7 1548 8 from from IN cord-005453-4057qib7 1548 9 third third JJ cord-005453-4057qib7 1548 10 - - HYPH cord-005453-4057qib7 1548 11 party party NN cord-005453-4057qib7 1548 12 bone bone NN cord-005453-4057qib7 1548 13 marrow marrow NN cord-005453-4057qib7 1548 14 donors donor NNS cord-005453-4057qib7 1548 15 at at IN cord-005453-4057qib7 1548 16 a a DT cord-005453-4057qib7 1548 17 2-week 2-week CD cord-005453-4057qib7 1548 18 interval interval NN cord-005453-4057qib7 1548 19 for for IN cord-005453-4057qib7 1548 20 a a DT cord-005453-4057qib7 1548 21 total total NN cord-005453-4057qib7 1548 22 of of IN cord-005453-4057qib7 1548 23 four four CD cord-005453-4057qib7 1548 24 doses dose NNS cord-005453-4057qib7 1548 25 . . . cord-005453-4057qib7 1549 1 Each each DT cord-005453-4057qib7 1549 2 dose dose NN cord-005453-4057qib7 1549 3 contained contain VBD cord-005453-4057qib7 1549 4 1x10 1x10 CD cord-005453-4057qib7 1549 5 6 6 CD cord-005453-4057qib7 1549 6 cells cell NNS cord-005453-4057qib7 1549 7 per per IN cord-005453-4057qib7 1549 8 kg kg NN cord-005453-4057qib7 1549 9 body body NN cord-005453-4057qib7 1549 10 weight weight NN cord-005453-4057qib7 1549 11 and and CC cord-005453-4057qib7 1549 12 all all DT cord-005453-4057qib7 1549 13 four four CD cord-005453-4057qib7 1549 14 doses dose NNS cord-005453-4057qib7 1549 15 consisted consist VBD cord-005453-4057qib7 1549 16 of of IN cord-005453-4057qib7 1549 17 MSCs msc NNS cord-005453-4057qib7 1549 18 from from IN cord-005453-4057qib7 1549 19 the the DT cord-005453-4057qib7 1549 20 same same JJ cord-005453-4057qib7 1549 21 donor donor NN cord-005453-4057qib7 1549 22 and and CC cord-005453-4057qib7 1549 23 same same JJ cord-005453-4057qib7 1549 24 passage passage NN cord-005453-4057qib7 1549 25 . . . cord-005453-4057qib7 1550 1 Results result NNS cord-005453-4057qib7 1550 2 : : : cord-005453-4057qib7 1551 1 We -PRON- PRP cord-005453-4057qib7 1551 2 enrolled enrol VBD cord-005453-4057qib7 1551 3 ten ten CD cord-005453-4057qib7 1551 4 patients patient NNS cord-005453-4057qib7 1551 5 ( ( -LRB- cord-005453-4057qib7 1551 6 3 3 CD cord-005453-4057qib7 1551 7 female/ female/ CD cord-005453-4057qib7 1551 8 7 7 CD cord-005453-4057qib7 1551 9 male male NN cord-005453-4057qib7 1551 10 , , , cord-005453-4057qib7 1551 11 with with IN cord-005453-4057qib7 1551 12 a a DT cord-005453-4057qib7 1551 13 median median JJ cord-005453-4057qib7 1551 14 age age NN cord-005453-4057qib7 1551 15 of of IN cord-005453-4057qib7 1551 16 41.5(range 41.5(range CD cord-005453-4057qib7 1551 17 17 17 CD cord-005453-4057qib7 1551 18 - - SYM cord-005453-4057qib7 1551 19 68 68 CD cord-005453-4057qib7 1551 20 ) ) -RRB- cord-005453-4057qib7 1551 21 . . . cord-005453-4057qib7 1552 1 Median Median NNP cord-005453-4057qib7 1552 2 of of IN cord-005453-4057qib7 1552 3 cGVHD cGVHD NNP cord-005453-4057qib7 1552 4 affected affect VBN cord-005453-4057qib7 1552 5 organs organ NNS cord-005453-4057qib7 1552 6 was be VBD cord-005453-4057qib7 1552 7 3 3 CD cord-005453-4057qib7 1553 1 ( ( -LRB- cord-005453-4057qib7 1553 2 range range NNP cord-005453-4057qib7 1553 3 2 2 CD cord-005453-4057qib7 1553 4 - - SYM cord-005453-4057qib7 1553 5 4 4 CD cord-005453-4057qib7 1553 6 ) ) -RRB- cord-005453-4057qib7 1553 7 including include VBG cord-005453-4057qib7 1553 8 the the DT cord-005453-4057qib7 1553 9 skin skin NN cord-005453-4057qib7 1553 10 ( ( -LRB- cord-005453-4057qib7 1553 11 n=4 n=4 NNS cord-005453-4057qib7 1553 12 ) ) -RRB- cord-005453-4057qib7 1553 13 , , , cord-005453-4057qib7 1553 14 eyes eye NNS cord-005453-4057qib7 1553 15 ( ( -LRB- cord-005453-4057qib7 1553 16 n=8 n=8 NN cord-005453-4057qib7 1553 17 ) ) -RRB- cord-005453-4057qib7 1553 18 , , , cord-005453-4057qib7 1553 19 oral oral JJ cord-005453-4057qib7 1553 20 cavity cavity NN cord-005453-4057qib7 1553 21 ( ( -LRB- cord-005453-4057qib7 1553 22 n=9 n=9 NN cord-005453-4057qib7 1553 23 ) ) -RRB- cord-005453-4057qib7 1553 24 , , , cord-005453-4057qib7 1553 25 lung lung NN cord-005453-4057qib7 1553 26 ( ( -LRB- cord-005453-4057qib7 1553 27 n=1 n=1 CD cord-005453-4057qib7 1553 28 ) ) -RRB- cord-005453-4057qib7 1553 29 , , , cord-005453-4057qib7 1553 30 liver liver NN cord-005453-4057qib7 1553 31 ( ( -LRB- cord-005453-4057qib7 1553 32 n=2 n=2 NNS cord-005453-4057qib7 1553 33 ) ) -RRB- cord-005453-4057qib7 1553 34 and and CC cord-005453-4057qib7 1553 35 joints joint NNS cord-005453-4057qib7 1553 36 ( ( -LRB- cord-005453-4057qib7 1553 37 n=6 n=6 NN cord-005453-4057qib7 1553 38 ) ) -RRB- cord-005453-4057qib7 1553 39 . . . cord-005453-4057qib7 1554 1 All all DT cord-005453-4057qib7 1554 2 ten ten CD cord-005453-4057qib7 1554 3 patients patient NNS cord-005453-4057qib7 1554 4 received receive VBD cord-005453-4057qib7 1554 5 their -PRON- PRP$ cord-005453-4057qib7 1554 6 planned plan VBN cord-005453-4057qib7 1554 7 four four CD cord-005453-4057qib7 1554 8 doses dose NNS cord-005453-4057qib7 1554 9 of of IN cord-005453-4057qib7 1554 10 MSCs msc NNS cord-005453-4057qib7 1554 11 , , , cord-005453-4057qib7 1554 12 administering administer VBG cord-005453-4057qib7 1554 13 a a DT cord-005453-4057qib7 1554 14 total total NN cord-005453-4057qib7 1554 15 of of IN cord-005453-4057qib7 1554 16 40 40 CD cord-005453-4057qib7 1554 17 infusions infusion NNS cord-005453-4057qib7 1554 18 . . . cord-005453-4057qib7 1555 1 Median median JJ cord-005453-4057qib7 1555 2 time time NN cord-005453-4057qib7 1555 3 from from IN cord-005453-4057qib7 1555 4 initial initial JJ cord-005453-4057qib7 1555 5 cGVHD cgvhd NN cord-005453-4057qib7 1555 6 diagnosis diagnosis NN cord-005453-4057qib7 1555 7 to to IN cord-005453-4057qib7 1555 8 first first JJ cord-005453-4057qib7 1555 9 MSC MSC NNP cord-005453-4057qib7 1555 10 treatment treatment NN cord-005453-4057qib7 1555 11 was be VBD cord-005453-4057qib7 1555 12 709 709 CD cord-005453-4057qib7 1555 13 days day NNS cord-005453-4057qib7 1556 1 ( ( -LRB- cord-005453-4057qib7 1556 2 range range NNP cord-005453-4057qib7 1556 3 222 222 CD cord-005453-4057qib7 1556 4 - - HYPH cord-005453-4057qib7 1556 5 4413 4413 CD cord-005453-4057qib7 1556 6 ) ) -RRB- cord-005453-4057qib7 1556 7 . . . cord-005453-4057qib7 1557 1 MSC MSC NNP cord-005453-4057qib7 1557 2 infusions infusion NNS cord-005453-4057qib7 1557 3 were be VBD cord-005453-4057qib7 1557 4 well well RB cord-005453-4057qib7 1557 5 tolerated tolerate VBN cord-005453-4057qib7 1557 6 with with IN cord-005453-4057qib7 1557 7 no no DT cord-005453-4057qib7 1557 8 immediate immediate JJ cord-005453-4057qib7 1557 9 or or CC cord-005453-4057qib7 1557 10 delayed delay VBN cord-005453-4057qib7 1557 11 toxicities toxicity NNS cord-005453-4057qib7 1557 12 . . . cord-005453-4057qib7 1558 1 After after IN cord-005453-4057qib7 1558 2 8 8 CD cord-005453-4057qib7 1558 3 weeks week NNS cord-005453-4057qib7 1558 4 of of IN cord-005453-4057qib7 1558 5 the the DT cord-005453-4057qib7 1558 6 first first JJ cord-005453-4057qib7 1558 7 MSC MSC NNP cord-005453-4057qib7 1558 8 infusion infusion NN cord-005453-4057qib7 1558 9 , , , cord-005453-4057qib7 1558 10 all all DT cord-005453-4057qib7 1558 11 ten ten CD cord-005453-4057qib7 1558 12 patients patient NNS cord-005453-4057qib7 1558 13 showed show VBD cord-005453-4057qib7 1558 14 partial partial JJ cord-005453-4057qib7 1558 15 response response NN cord-005453-4057qib7 1558 16 showing show VBG cord-005453-4057qib7 1558 17 alleviation alleviation NN cord-005453-4057qib7 1558 18 in in IN cord-005453-4057qib7 1558 19 clinical clinical JJ cord-005453-4057qib7 1558 20 symptoms symptom NNS cord-005453-4057qib7 1558 21 and and CC cord-005453-4057qib7 1558 22 increased increase VBN cord-005453-4057qib7 1558 23 quality quality NN cord-005453-4057qib7 1558 24 of of IN cord-005453-4057qib7 1558 25 life life NN cord-005453-4057qib7 1558 26 . . . cord-005453-4057qib7 1559 1 Organ organ NN cord-005453-4057qib7 1559 2 responses response NNS cord-005453-4057qib7 1559 3 were be VBD cord-005453-4057qib7 1559 4 seen see VBN cord-005453-4057qib7 1559 5 in in IN cord-005453-4057qib7 1559 6 skin skin NN cord-005453-4057qib7 1559 7 ( ( -LRB- cord-005453-4057qib7 1559 8 n=2 n=2 NNS cord-005453-4057qib7 1559 9 ) ) -RRB- cord-005453-4057qib7 1559 10 , , , cord-005453-4057qib7 1559 11 eyes eye NNS cord-005453-4057qib7 1559 12 ( ( -LRB- cord-005453-4057qib7 1559 13 n=5 n=5 NNP cord-005453-4057qib7 1559 14 ) ) -RRB- cord-005453-4057qib7 1559 15 , , , cord-005453-4057qib7 1559 16 oral oral JJ cord-005453-4057qib7 1559 17 cavity cavity NN cord-005453-4057qib7 1559 18 ( ( -LRB- cord-005453-4057qib7 1559 19 n=8 n=8 NN cord-005453-4057qib7 1559 20 ) ) -RRB- cord-005453-4057qib7 1559 21 , , , cord-005453-4057qib7 1559 22 liver liver NN cord-005453-4057qib7 1559 23 ( ( -LRB- cord-005453-4057qib7 1559 24 n=1 n=1 CD cord-005453-4057qib7 1559 25 ) ) -RRB- cord-005453-4057qib7 1559 26 , , , cord-005453-4057qib7 1559 27 and and CC cord-005453-4057qib7 1559 28 joint(n=5 joint(n=5 NNP cord-005453-4057qib7 1559 29 ) ) -RRB- cord-005453-4057qib7 1559 30 . . . cord-005453-4057qib7 1560 1 However however RB cord-005453-4057qib7 1560 2 , , , cord-005453-4057qib7 1560 3 one one CD cord-005453-4057qib7 1560 4 patient patient NN cord-005453-4057qib7 1560 5 died die VBD cord-005453-4057qib7 1560 6 of of IN cord-005453-4057qib7 1560 7 progressive progressive JJ cord-005453-4057qib7 1560 8 GVHD GVHD NNP cord-005453-4057qib7 1560 9 and and CC cord-005453-4057qib7 1560 10 one one CD cord-005453-4057qib7 1560 11 patient patient NN cord-005453-4057qib7 1560 12 relapsed relapse VBD cord-005453-4057qib7 1560 13 from from IN cord-005453-4057qib7 1560 14 primary primary JJ cord-005453-4057qib7 1560 15 disease disease NN cord-005453-4057qib7 1560 16 . . . cord-005453-4057qib7 1561 1 Conclusions conclusion NNS cord-005453-4057qib7 1561 2 : : : cord-005453-4057qib7 1562 1 Repeated repeat VBN cord-005453-4057qib7 1562 2 infusions infusion NNS cord-005453-4057qib7 1562 3 of of IN cord-005453-4057qib7 1562 4 MSCs msc NNS cord-005453-4057qib7 1562 5 was be VBD cord-005453-4057qib7 1562 6 feasible feasible JJ cord-005453-4057qib7 1562 7 and and CC cord-005453-4057qib7 1562 8 safe safe JJ cord-005453-4057qib7 1562 9 and and CC cord-005453-4057qib7 1562 10 may may MD cord-005453-4057qib7 1562 11 be be VB cord-005453-4057qib7 1562 12 an an DT cord-005453-4057qib7 1562 13 effective effective JJ cord-005453-4057qib7 1562 14 salvage salvage NN cord-005453-4057qib7 1562 15 therapy therapy NN cord-005453-4057qib7 1562 16 in in IN cord-005453-4057qib7 1562 17 patients patient NNS cord-005453-4057qib7 1562 18 with with IN cord-005453-4057qib7 1562 19 steroid steroid JJ cord-005453-4057qib7 1562 20 - - HYPH cord-005453-4057qib7 1562 21 refractory refractory JJ cord-005453-4057qib7 1562 22 cGVHD cgvhd NN cord-005453-4057qib7 1562 23 . . . cord-005453-4057qib7 1563 1 Further further JJ cord-005453-4057qib7 1563 2 large large JJ cord-005453-4057qib7 1563 3 - - HYPH cord-005453-4057qib7 1563 4 scale scale NN cord-005453-4057qib7 1563 5 clinical clinical JJ cord-005453-4057qib7 1563 6 studies study NNS cord-005453-4057qib7 1563 7 with with IN cord-005453-4057qib7 1563 8 long long JJ cord-005453-4057qib7 1563 9 - - HYPH cord-005453-4057qib7 1563 10 term term NN cord-005453-4057qib7 1563 11 follow follow VB cord-005453-4057qib7 1563 12 up up RP cord-005453-4057qib7 1563 13 is be VBZ cord-005453-4057qib7 1563 14 needed need VBN cord-005453-4057qib7 1563 15 in in IN cord-005453-4057qib7 1563 16 the the DT cord-005453-4057qib7 1563 17 future future NN cord-005453-4057qib7 1563 18 to to TO cord-005453-4057qib7 1563 19 determine determine VB cord-005453-4057qib7 1563 20 the the DT cord-005453-4057qib7 1563 21 role role NN cord-005453-4057qib7 1563 22 of of IN cord-005453-4057qib7 1563 23 MSCs msc NNS cord-005453-4057qib7 1563 24 in in IN cord-005453-4057qib7 1563 25 cGVHD cGVHD NNP cord-005453-4057qib7 1563 26 . . . cord-005453-4057qib7 1564 1 Background background NN cord-005453-4057qib7 1564 2 : : : cord-005453-4057qib7 1565 1 The the DT cord-005453-4057qib7 1565 2 majority majority NN cord-005453-4057qib7 1565 3 of of IN cord-005453-4057qib7 1565 4 pregnant pregnant JJ cord-005453-4057qib7 1565 5 Polish polish JJ cord-005453-4057qib7 1565 6 women woman NNS cord-005453-4057qib7 1565 7 ( ( -LRB- cord-005453-4057qib7 1565 8 84 84 CD cord-005453-4057qib7 1565 9 % % NN cord-005453-4057qib7 1565 10 ) ) -RRB- cord-005453-4057qib7 1565 11 have have VBP cord-005453-4057qib7 1565 12 heard hear VBN cord-005453-4057qib7 1565 13 of of IN cord-005453-4057qib7 1565 14 cord cord NN cord-005453-4057qib7 1565 15 blood blood NN cord-005453-4057qib7 1565 16 banking banking NN cord-005453-4057qib7 1565 17 . . . cord-005453-4057qib7 1566 1 However however RB cord-005453-4057qib7 1566 2 , , , cord-005453-4057qib7 1566 3 most most JJS cord-005453-4057qib7 1566 4 doctors doctor NNS cord-005453-4057qib7 1566 5 do do VBP cord-005453-4057qib7 1566 6 not not RB cord-005453-4057qib7 1566 7 have have VB cord-005453-4057qib7 1566 8 sufficient sufficient JJ cord-005453-4057qib7 1566 9 knowledge knowledge NN cord-005453-4057qib7 1566 10 about about IN cord-005453-4057qib7 1566 11 the the DT cord-005453-4057qib7 1566 12 possibility possibility NN cord-005453-4057qib7 1566 13 of of IN cord-005453-4057qib7 1566 14 using use VBG cord-005453-4057qib7 1566 15 cord cord NN cord-005453-4057qib7 1566 16 blood blood NN cord-005453-4057qib7 1566 17 in in IN cord-005453-4057qib7 1566 18 order order NN cord-005453-4057qib7 1566 19 to to TO cord-005453-4057qib7 1566 20 respond respond VB cord-005453-4057qib7 1566 21 to to IN cord-005453-4057qib7 1566 22 their -PRON- PRP$ cord-005453-4057qib7 1566 23 potential potential JJ cord-005453-4057qib7 1566 24 concerns concern NNS cord-005453-4057qib7 1566 25 . . . cord-005453-4057qib7 1567 1 Only only RB cord-005453-4057qib7 1567 2 16.5 16.5 CD cord-005453-4057qib7 1567 3 % % NN cord-005453-4057qib7 1567 4 of of IN cord-005453-4057qib7 1567 5 healthcare healthcare NN cord-005453-4057qib7 1567 6 professionals professional NNS cord-005453-4057qib7 1567 7 were be VBD cord-005453-4057qib7 1567 8 aware aware JJ cord-005453-4057qib7 1567 9 that that IN cord-005453-4057qib7 1567 10 cord cord NN cord-005453-4057qib7 1567 11 blood blood NN cord-005453-4057qib7 1567 12 could could MD cord-005453-4057qib7 1567 13 be be VB cord-005453-4057qib7 1567 14 used use VBN cord-005453-4057qib7 1567 15 to to TO cord-005453-4057qib7 1567 16 treat treat VB cord-005453-4057qib7 1567 17 haematological haematological JJ cord-005453-4057qib7 1567 18 diseases disease NNS cord-005453-4057qib7 1567 19 . . . cord-005453-4057qib7 1568 1 In in IN cord-005453-4057qib7 1568 2 order order NN cord-005453-4057qib7 1568 3 to to TO cord-005453-4057qib7 1568 4 make make VB cord-005453-4057qib7 1568 5 doctors doctor NNS cord-005453-4057qib7 1568 6 aware aware JJ cord-005453-4057qib7 1568 7 of of IN cord-005453-4057qib7 1568 8 this this DT cord-005453-4057qib7 1568 9 issue issue NN cord-005453-4057qib7 1568 10 and and CC cord-005453-4057qib7 1568 11 provide provide VB cord-005453-4057qib7 1568 12 patients patient NNS cord-005453-4057qib7 1568 13 with with IN cord-005453-4057qib7 1568 14 the the DT cord-005453-4057qib7 1568 15 information information NN cord-005453-4057qib7 1568 16 they -PRON- PRP cord-005453-4057qib7 1568 17 expect expect VBP cord-005453-4057qib7 1568 18 , , , cord-005453-4057qib7 1568 19 we -PRON- PRP cord-005453-4057qib7 1568 20 would would MD cord-005453-4057qib7 1568 21 like like VB cord-005453-4057qib7 1568 22 to to TO cord-005453-4057qib7 1568 23 present present VB cord-005453-4057qib7 1568 24 data datum NNS cord-005453-4057qib7 1568 25 on on IN cord-005453-4057qib7 1568 26 the the DT cord-005453-4057qib7 1568 27 use use NN cord-005453-4057qib7 1568 28 of of IN cord-005453-4057qib7 1568 29 cord cord NN cord-005453-4057qib7 1568 30 blood blood NN cord-005453-4057qib7 1568 31 stored store VBN cord-005453-4057qib7 1568 32 in in IN cord-005453-4057qib7 1568 33 our -PRON- PRP$ cord-005453-4057qib7 1568 34 blood blood NN cord-005453-4057qib7 1568 35 bank bank NN cord-005453-4057qib7 1568 36 for for IN cord-005453-4057qib7 1568 37 haematological haematological JJ cord-005453-4057qib7 1568 38 and and CC cord-005453-4057qib7 1568 39 nonhaematological nonhaematological JJ cord-005453-4057qib7 1568 40 therapies therapy NNS cord-005453-4057qib7 1568 41 . . . cord-005453-4057qib7 1569 1 Methods method NNS cord-005453-4057qib7 1569 2 : : : cord-005453-4057qib7 1570 1 The the DT cord-005453-4057qib7 1570 2 table table NN cord-005453-4057qib7 1570 3 presented present VBN cord-005453-4057qib7 1570 4 below below RB cord-005453-4057qib7 1570 5 has have VBZ cord-005453-4057qib7 1570 6 been be VBN cord-005453-4057qib7 1570 7 created create VBN cord-005453-4057qib7 1570 8 using use VBG cord-005453-4057qib7 1570 9 data datum NNS cord-005453-4057qib7 1570 10 from from IN cord-005453-4057qib7 1570 11 the the DT cord-005453-4057qib7 1570 12 general general JJ cord-005453-4057qib7 1570 13 database database NN cord-005453-4057qib7 1570 14 of of IN cord-005453-4057qib7 1570 15 the the DT cord-005453-4057qib7 1570 16 Polish Polish NNP cord-005453-4057qib7 1570 17 Stem Stem NNP cord-005453-4057qib7 1570 18 Cell Cell NNP cord-005453-4057qib7 1570 19 Bank Bank NNP cord-005453-4057qib7 1570 20 , , , cord-005453-4057qib7 1570 21 Warsaw Warsaw NNP cord-005453-4057qib7 1570 22 , , , cord-005453-4057qib7 1570 23 Poland Poland NNP cord-005453-4057qib7 1570 24 . . . cord-005453-4057qib7 1571 1 No no DT cord-005453-4057qib7 1571 2 data datum NNS cord-005453-4057qib7 1571 3 regarding regard VBG cord-005453-4057qib7 1571 4 umbilical umbilical JJ cord-005453-4057qib7 1571 5 cord cord NN cord-005453-4057qib7 1571 6 blood blood NN cord-005453-4057qib7 1571 7 data datum NNS cord-005453-4057qib7 1571 8 have have VBP cord-005453-4057qib7 1571 9 been be VBN cord-005453-4057qib7 1571 10 excluded exclude VBN cord-005453-4057qib7 1571 11 . . . cord-005453-4057qib7 1572 1 All all DT cord-005453-4057qib7 1572 2 patients patient NNS cord-005453-4057qib7 1572 3 were be VBD cord-005453-4057qib7 1572 4 planned plan VBN cord-005453-4057qib7 1572 5 to to TO cord-005453-4057qib7 1572 6 be be VB cord-005453-4057qib7 1572 7 assessed assess VBN cord-005453-4057qib7 1572 8 on on IN cord-005453-4057qib7 1572 9 day day NN cord-005453-4057qib7 1572 10 1 1 CD cord-005453-4057qib7 1572 11 , , , cord-005453-4057qib7 1572 12 day day NN cord-005453-4057qib7 1572 13 28 28 CD cord-005453-4057qib7 1572 14 , , , cord-005453-4057qib7 1572 15 on on IN cord-005453-4057qib7 1572 16 discharge discharge NN cord-005453-4057qib7 1572 17 , , , cord-005453-4057qib7 1572 18 100 100 CD cord-005453-4057qib7 1572 19 days day NNS cord-005453-4057qib7 1572 20 after after IN cord-005453-4057qib7 1572 21 transplantation transplantation NN cord-005453-4057qib7 1572 22 and and CC cord-005453-4057qib7 1572 23 1 1 CD cord-005453-4057qib7 1572 24 , , , cord-005453-4057qib7 1572 25 2 2 CD cord-005453-4057qib7 1572 26 , , , cord-005453-4057qib7 1572 27 3 3 CD cord-005453-4057qib7 1572 28 , , , cord-005453-4057qib7 1572 29 4 4 CD cord-005453-4057qib7 1572 30 , , , cord-005453-4057qib7 1572 31 and and CC cord-005453-4057qib7 1572 32 5 5 CD cord-005453-4057qib7 1572 33 years year NNS cord-005453-4057qib7 1572 34 after after IN cord-005453-4057qib7 1572 35 transplantation transplantation NN cord-005453-4057qib7 1572 36 , , , cord-005453-4057qib7 1572 37 but but CC cord-005453-4057qib7 1572 38 in in IN cord-005453-4057qib7 1572 39 some some DT cord-005453-4057qib7 1572 40 cases case NNS cord-005453-4057qib7 1572 41 , , , cord-005453-4057qib7 1572 42 patients patient NNS cord-005453-4057qib7 1572 43 were be VBD cord-005453-4057qib7 1572 44 lost lose VBN cord-005453-4057qib7 1572 45 from from IN cord-005453-4057qib7 1572 46 follow follow NN cord-005453-4057qib7 1572 47 - - HYPH cord-005453-4057qib7 1572 48 up up NN cord-005453-4057qib7 1572 49 due due IN cord-005453-4057qib7 1572 50 to to IN cord-005453-4057qib7 1572 51 a a DT cord-005453-4057qib7 1572 52 persistent persistent JJ cord-005453-4057qib7 1572 53 lack lack NN cord-005453-4057qib7 1572 54 of of IN cord-005453-4057qib7 1572 55 reports report NNS cord-005453-4057qib7 1572 56 from from IN cord-005453-4057qib7 1572 57 transplantation transplantation NN cord-005453-4057qib7 1572 58 centres centre NNS cord-005453-4057qib7 1572 59 . . . cord-005453-4057qib7 1573 1 Results result NNS cord-005453-4057qib7 1573 2 : : : cord-005453-4057qib7 1574 1 In in IN cord-005453-4057qib7 1574 2 32 32 CD cord-005453-4057qib7 1574 3 cases case NNS cord-005453-4057qib7 1574 4 , , , cord-005453-4057qib7 1574 5 the the DT cord-005453-4057qib7 1574 6 therapeutic therapeutic JJ cord-005453-4057qib7 1574 7 use use NN cord-005453-4057qib7 1574 8 of of IN cord-005453-4057qib7 1574 9 CB CB NNP cord-005453-4057qib7 1574 10 was be VBD cord-005453-4057qib7 1574 11 transplantation transplantation NN cord-005453-4057qib7 1574 12 ( ( -LRB- cord-005453-4057qib7 1574 13 replacement replacement NN cord-005453-4057qib7 1574 14 of of IN cord-005453-4057qib7 1574 15 patients patient NNS cord-005453-4057qib7 1574 16 ' ' POS cord-005453-4057qib7 1574 17 own own JJ cord-005453-4057qib7 1574 18 tissue tissue NN cord-005453-4057qib7 1574 19 ) ) -RRB- cord-005453-4057qib7 1574 20 ; ; : cord-005453-4057qib7 1574 21 in in IN cord-005453-4057qib7 1574 22 13 13 CD cord-005453-4057qib7 1574 23 cases case NNS cord-005453-4057qib7 1574 24 it -PRON- PRP cord-005453-4057qib7 1574 25 was be VBD cord-005453-4057qib7 1574 26 administration administration NN cord-005453-4057qib7 1574 27 ( ( -LRB- cord-005453-4057qib7 1574 28 infusion infusion NN cord-005453-4057qib7 1574 29 without without IN cord-005453-4057qib7 1574 30 destruction destruction NN cord-005453-4057qib7 1574 31 of of IN cord-005453-4057qib7 1574 32 patients patient NNS cord-005453-4057qib7 1574 33 ' ' POS cord-005453-4057qib7 1574 34 own own JJ cord-005453-4057qib7 1574 35 tissue tissue NN cord-005453-4057qib7 1574 36 ) ) -RRB- cord-005453-4057qib7 1574 37 . . . cord-005453-4057qib7 1575 1 Thirty thirty CD cord-005453-4057qib7 1575 2 - - HYPH cord-005453-4057qib7 1575 3 three three CD cord-005453-4057qib7 1575 4 were be VBD cord-005453-4057qib7 1575 5 administered administer VBN cord-005453-4057qib7 1575 6 as as IN cord-005453-4057qib7 1575 7 standard standard JJ cord-005453-4057qib7 1575 8 therapy therapy NN cord-005453-4057qib7 1575 9 and and CC cord-005453-4057qib7 1575 10 13 13 CD cord-005453-4057qib7 1575 11 as as IN cord-005453-4057qib7 1575 12 experimental experimental JJ cord-005453-4057qib7 1575 13 therapy therapy NN cord-005453-4057qib7 1575 14 . . . cord-005453-4057qib7 1576 1 Conclusions conclusion NNS cord-005453-4057qib7 1576 2 : : : cord-005453-4057qib7 1577 1 The the DT cord-005453-4057qib7 1577 2 survey survey NN cord-005453-4057qib7 1577 3 study study NN cord-005453-4057qib7 1577 4 cited cite VBN cord-005453-4057qib7 1577 5 above above RB cord-005453-4057qib7 1577 6 , , , cord-005453-4057qib7 1577 7 indicated indicate VBD cord-005453-4057qib7 1577 8 low low JJ cord-005453-4057qib7 1577 9 awareness awareness NN cord-005453-4057qib7 1577 10 of of IN cord-005453-4057qib7 1577 11 cord cord NN cord-005453-4057qib7 1577 12 blood blood NN cord-005453-4057qib7 1577 13 use use NN cord-005453-4057qib7 1577 14 among among IN cord-005453-4057qib7 1577 15 healthcare healthcare NN cord-005453-4057qib7 1577 16 professionals professional NNS cord-005453-4057qib7 1577 17 . . . cord-005453-4057qib7 1578 1 On on IN cord-005453-4057qib7 1578 2 the the DT cord-005453-4057qib7 1578 3 other other JJ cord-005453-4057qib7 1578 4 hand hand NN cord-005453-4057qib7 1578 5 , , , cord-005453-4057qib7 1578 6 one one CD cord-005453-4057qib7 1578 7 study study NN cord-005453-4057qib7 1578 8 indicated indicate VBD cord-005453-4057qib7 1578 9 that that IN cord-005453-4057qib7 1578 10 the the DT cord-005453-4057qib7 1578 11 expectations expectation NNS cord-005453-4057qib7 1578 12 placed place VBN cord-005453-4057qib7 1578 13 in in IN cord-005453-4057qib7 1578 14 cord cord NN cord-005453-4057qib7 1578 15 blood blood NN cord-005453-4057qib7 1578 16 banking banking NN cord-005453-4057qib7 1578 17 may may MD cord-005453-4057qib7 1578 18 be be VB cord-005453-4057qib7 1578 19 unreasonable unreasonable JJ cord-005453-4057qib7 1578 20 . . . cord-005453-4057qib7 1579 1 As as IN cord-005453-4057qib7 1579 2 a a DT cord-005453-4057qib7 1579 3 private private JJ cord-005453-4057qib7 1579 4 cord cord NN cord-005453-4057qib7 1579 5 blood blood NN cord-005453-4057qib7 1579 6 bank bank NN cord-005453-4057qib7 1579 7 , , , cord-005453-4057qib7 1579 8 we -PRON- PRP cord-005453-4057qib7 1579 9 support support VBP cord-005453-4057qib7 1579 10 recommendations recommendation NNS cord-005453-4057qib7 1579 11 which which WDT cord-005453-4057qib7 1579 12 underline underline VBP cord-005453-4057qib7 1579 13 the the DT cord-005453-4057qib7 1579 14 importance importance NN cord-005453-4057qib7 1579 15 of of IN cord-005453-4057qib7 1579 16 patient patient JJ cord-005453-4057qib7 1579 17 education education NN cord-005453-4057qib7 1579 18 . . . cord-005453-4057qib7 1580 1 In in IN cord-005453-4057qib7 1580 2 Poland Poland NNP cord-005453-4057qib7 1580 3 , , , cord-005453-4057qib7 1580 4 cord cord NN cord-005453-4057qib7 1580 5 blood blood NN cord-005453-4057qib7 1580 6 has have VBZ cord-005453-4057qib7 1580 7 been be VBN cord-005453-4057qib7 1580 8 approved approve VBN cord-005453-4057qib7 1580 9 as as IN cord-005453-4057qib7 1580 10 standard standard JJ cord-005453-4057qib7 1580 11 therapy therapy NN cord-005453-4057qib7 1580 12 in in IN cord-005453-4057qib7 1580 13 approx approx NN cord-005453-4057qib7 1580 14 . . . cord-005453-4057qib7 1581 1 80 80 CD cord-005453-4057qib7 1581 2 diseases disease NNS cord-005453-4057qib7 1581 3 ; ; : cord-005453-4057qib7 1581 4 most most JJS cord-005453-4057qib7 1581 5 of of IN cord-005453-4057qib7 1581 6 them -PRON- PRP cord-005453-4057qib7 1581 7 are be VBP cord-005453-4057qib7 1581 8 rare rare JJ cord-005453-4057qib7 1581 9 , , , cord-005453-4057qib7 1581 10 but but CC cord-005453-4057qib7 1581 11 Polish polish JJ cord-005453-4057qib7 1581 12 law law NN cord-005453-4057qib7 1581 13 allows allow VBZ cord-005453-4057qib7 1581 14 the the DT cord-005453-4057qib7 1581 15 use use NN cord-005453-4057qib7 1581 16 of of IN cord-005453-4057qib7 1581 17 cord cord NN cord-005453-4057qib7 1581 18 blood blood NN cord-005453-4057qib7 1581 19 for for IN cord-005453-4057qib7 1581 20 the the DT cord-005453-4057qib7 1581 21 siblings sibling NNS cord-005453-4057qib7 1581 22 , , , cord-005453-4057qib7 1581 23 parents parent NNS cord-005453-4057qib7 1581 24 and and CC cord-005453-4057qib7 1581 25 grandparents grandparent NNS cord-005453-4057qib7 1581 26 of of IN cord-005453-4057qib7 1581 27 a a DT cord-005453-4057qib7 1581 28 donor donor NN cord-005453-4057qib7 1581 29 . . . cord-005453-4057qib7 1582 1 Additionally additionally RB cord-005453-4057qib7 1582 2 , , , cord-005453-4057qib7 1582 3 168 168 CD cord-005453-4057qib7 1582 4 active active JJ cord-005453-4057qib7 1582 5 and and CC cord-005453-4057qib7 1582 6 planned planned JJ cord-005453-4057qib7 1582 7 clinical clinical JJ cord-005453-4057qib7 1582 8 trials trial NNS cord-005453-4057qib7 1582 9 throughout throughout IN cord-005453-4057qib7 1582 10 the the DT cord-005453-4057qib7 1582 11 world world NN cord-005453-4057qib7 1582 12 evaluate evaluate VBP cord-005453-4057qib7 1582 13 the the DT cord-005453-4057qib7 1582 14 therapeutic therapeutic JJ cord-005453-4057qib7 1582 15 efficacy efficacy NN cord-005453-4057qib7 1582 16 of of IN cord-005453-4057qib7 1582 17 cord cord NN cord-005453-4057qib7 1582 18 blood blood NN cord-005453-4057qib7 1582 19 in in IN cord-005453-4057qib7 1582 20 such such JJ cord-005453-4057qib7 1582 21 areas area NNS cord-005453-4057qib7 1582 22 as as IN cord-005453-4057qib7 1582 23 haematology haematology NNP cord-005453-4057qib7 1582 24 , , , cord-005453-4057qib7 1582 25 neurology neurology NN cord-005453-4057qib7 1582 26 , , , cord-005453-4057qib7 1582 27 cardiology cardiology NN cord-005453-4057qib7 1582 28 , , , cord-005453-4057qib7 1582 29 diabetology diabetology NN cord-005453-4057qib7 1582 30 , , , cord-005453-4057qib7 1582 31 congenital congenital JJ cord-005453-4057qib7 1582 32 paediatric paediatric JJ cord-005453-4057qib7 1582 33 disorders disorder NNS cord-005453-4057qib7 1582 34 , , , cord-005453-4057qib7 1582 35 ophthalmology ophthalmology NN cord-005453-4057qib7 1582 36 , , , cord-005453-4057qib7 1582 37 dermatology dermatology NN cord-005453-4057qib7 1582 38 , , , cord-005453-4057qib7 1582 39 gastroenterology gastroenterology NN cord-005453-4057qib7 1582 40 , , , cord-005453-4057qib7 1582 41 HIV HIV NNP cord-005453-4057qib7 1582 42 infection infection NN cord-005453-4057qib7 1582 43 , , , cord-005453-4057qib7 1582 44 and and CC cord-005453-4057qib7 1582 45 the the DT cord-005453-4057qib7 1582 46 quality quality NN cord-005453-4057qib7 1582 47 of of IN cord-005453-4057qib7 1582 48 life life NN cord-005453-4057qib7 1582 49 during during IN cord-005453-4057qib7 1582 50 aging age VBG cord-005453-4057qib7 1582 51 . . . cord-005453-4057qib7 1583 1 Therefore therefore RB cord-005453-4057qib7 1583 2 , , , cord-005453-4057qib7 1583 3 further further JJ cord-005453-4057qib7 1583 4 indications indication NNS cord-005453-4057qib7 1583 5 may may MD cord-005453-4057qib7 1583 6 be be VB cord-005453-4057qib7 1583 7 expected expect VBN cord-005453-4057qib7 1583 8 in in IN cord-005453-4057qib7 1583 9 the the DT cord-005453-4057qib7 1583 10 future future NN cord-005453-4057qib7 1583 11 . . . cord-005453-4057qib7 1584 1 Background background NN cord-005453-4057qib7 1584 2 : : : cord-005453-4057qib7 1585 1 Cytokine cytokine NN cord-005453-4057qib7 1585 2 release release NN cord-005453-4057qib7 1585 3 syndrome syndrome NN cord-005453-4057qib7 1585 4 ( ( -LRB- cord-005453-4057qib7 1585 5 CRS CRS NNP cord-005453-4057qib7 1585 6 ) ) -RRB- cord-005453-4057qib7 1585 7 has have VBZ cord-005453-4057qib7 1585 8 been be VBN cord-005453-4057qib7 1585 9 identified identify VBN cord-005453-4057qib7 1585 10 as as IN cord-005453-4057qib7 1585 11 a a DT cord-005453-4057qib7 1585 12 clinically clinically RB cord-005453-4057qib7 1585 13 significant significant JJ cord-005453-4057qib7 1585 14 , , , cord-005453-4057qib7 1585 15 on on IN cord-005453-4057qib7 1585 16 target target NN cord-005453-4057qib7 1585 17 , , , cord-005453-4057qib7 1585 18 off off IN cord-005453-4057qib7 1585 19 tumour tumour NN cord-005453-4057qib7 1585 20 side side NN cord-005453-4057qib7 1585 21 effect effect NN cord-005453-4057qib7 1585 22 of of IN cord-005453-4057qib7 1585 23 the the DT cord-005453-4057qib7 1585 24 chimeric chimeric JJ cord-005453-4057qib7 1585 25 antigen antigen NN cord-005453-4057qib7 1585 26 receptor receptor NN cord-005453-4057qib7 1585 27 ( ( -LRB- cord-005453-4057qib7 1585 28 CAR car NN cord-005453-4057qib7 1585 29 ) ) -RRB- cord-005453-4057qib7 1585 30 T T NNP cord-005453-4057qib7 1585 31 - - HYPH cord-005453-4057qib7 1585 32 Cell cell NN cord-005453-4057qib7 1585 33 therapies therapy NNS cord-005453-4057qib7 1585 34 . . . cord-005453-4057qib7 1586 1 It -PRON- PRP cord-005453-4057qib7 1586 2 is be VBZ cord-005453-4057qib7 1586 3 clinically clinically RB cord-005453-4057qib7 1586 4 increased increase VBN cord-005453-4057qib7 1586 5 in in IN cord-005453-4057qib7 1586 6 interkeukin interkeukin NNP cord-005453-4057qib7 1586 7 6 6 CD cord-005453-4057qib7 1586 8 and and CC cord-005453-4057qib7 1586 9 elevations elevation NNS cord-005453-4057qib7 1586 10 in in IN cord-005453-4057qib7 1586 11 other other JJ cord-005453-4057qib7 1586 12 cytokines cytokine NNS cord-005453-4057qib7 1586 13 , , , cord-005453-4057qib7 1586 14 lactate lactate NN cord-005453-4057qib7 1586 15 dehydrogenase dehydrogenase NN cord-005453-4057qib7 1586 16 ( ( -LRB- cord-005453-4057qib7 1586 17 LDH LDH NNP cord-005453-4057qib7 1586 18 ) ) -RRB- cord-005453-4057qib7 1586 19 , , , cord-005453-4057qib7 1586 20 C C NNP cord-005453-4057qib7 1586 21 - - HYPH cord-005453-4057qib7 1586 22 reactive reactive JJ cord-005453-4057qib7 1586 23 protein protein NN cord-005453-4057qib7 1586 24 ( ( -LRB- cord-005453-4057qib7 1586 25 CRP CRP NNP cord-005453-4057qib7 1586 26 ) ) -RRB- cord-005453-4057qib7 1586 27 , , , cord-005453-4057qib7 1586 28 and and CC cord-005453-4057qib7 1586 29 ferritin ferritin NN cord-005453-4057qib7 1586 30 . . . cord-005453-4057qib7 1587 1 These these DT cord-005453-4057qib7 1587 2 side side NN cord-005453-4057qib7 1587 3 effects effect NNS cord-005453-4057qib7 1587 4 can can MD cord-005453-4057qib7 1587 5 include include VB cord-005453-4057qib7 1587 6 fever fever NN cord-005453-4057qib7 1587 7 , , , cord-005453-4057qib7 1587 8 fatigue fatigue NN cord-005453-4057qib7 1587 9 , , , cord-005453-4057qib7 1587 10 headache headache NN cord-005453-4057qib7 1587 11 , , , cord-005453-4057qib7 1587 12 encephalopathy encephalopathy NN cord-005453-4057qib7 1587 13 , , , cord-005453-4057qib7 1587 14 hypertension hypertension NN cord-005453-4057qib7 1587 15 , , , cord-005453-4057qib7 1587 16 tachycardia tachycardia NN cord-005453-4057qib7 1587 17 , , , cord-005453-4057qib7 1587 18 coagulopathy coagulopathy NN cord-005453-4057qib7 1587 19 , , , cord-005453-4057qib7 1587 20 nausea nausea NN cord-005453-4057qib7 1587 21 , , , cord-005453-4057qib7 1587 22 capillary capillary JJ cord-005453-4057qib7 1587 23 leak leak NN cord-005453-4057qib7 1587 24 and and CC cord-005453-4057qib7 1587 25 multi multi JJ cord-005453-4057qib7 1587 26 organ organ NN cord-005453-4057qib7 1587 27 dysfunction dysfunction NN cord-005453-4057qib7 1587 28 . . . cord-005453-4057qib7 1588 1 CRS CRS NNP cord-005453-4057qib7 1588 2 symptoms symptom NNS cord-005453-4057qib7 1588 3 can can MD cord-005453-4057qib7 1588 4 appear appear VB cord-005453-4057qib7 1588 5 as as RB cord-005453-4057qib7 1588 6 early early RB cord-005453-4057qib7 1588 7 as as IN cord-005453-4057qib7 1588 8 one one CD cord-005453-4057qib7 1588 9 day day NN cord-005453-4057qib7 1588 10 after after IN cord-005453-4057qib7 1588 11 infusion infusion NN cord-005453-4057qib7 1588 12 and and CC cord-005453-4057qib7 1588 13 can can MD cord-005453-4057qib7 1588 14 resolve resolve VB cord-005453-4057qib7 1588 15 quickly quickly RB cord-005453-4057qib7 1588 16 or or CC cord-005453-4057qib7 1588 17 last last JJ cord-005453-4057qib7 1588 18 for for IN cord-005453-4057qib7 1588 19 weeks week NNS cord-005453-4057qib7 1588 20 . . . cord-005453-4057qib7 1589 1 It´s It´s NNP cord-005453-4057qib7 1589 2 severity severity NN cord-005453-4057qib7 1589 3 to to TO cord-005453-4057qib7 1589 4 be be VB cord-005453-4057qib7 1589 5 related relate VBN cord-005453-4057qib7 1589 6 to to IN cord-005453-4057qib7 1589 7 the the DT cord-005453-4057qib7 1589 8 disease disease NN cord-005453-4057qib7 1589 9 burden burden NN cord-005453-4057qib7 1589 10 prior prior RB cord-005453-4057qib7 1589 11 to to IN cord-005453-4057qib7 1589 12 CAR CAR NNP cord-005453-4057qib7 1589 13 T T NNP cord-005453-4057qib7 1589 14 - - HYPH cord-005453-4057qib7 1589 15 Cell cell NN cord-005453-4057qib7 1589 16 therapy therapy NN cord-005453-4057qib7 1589 17 . . . cord-005453-4057qib7 1590 1 Methods method NNS cord-005453-4057qib7 1590 2 : : : cord-005453-4057qib7 1590 3 The the DT cord-005453-4057qib7 1590 4 Bristol Bristol NNP cord-005453-4057qib7 1590 5 Oncology Oncology NNP cord-005453-4057qib7 1590 6 and and CC cord-005453-4057qib7 1590 7 Haematology Haematology NNP cord-005453-4057qib7 1590 8 centre centre NN cord-005453-4057qib7 1590 9 will will MD cord-005453-4057qib7 1590 10 be be VB cord-005453-4057qib7 1590 11 providing provide VBG cord-005453-4057qib7 1590 12 CAR car NN cord-005453-4057qib7 1590 13 T T NNP cord-005453-4057qib7 1590 14 - - HYPH cord-005453-4057qib7 1590 15 Cell cell NN cord-005453-4057qib7 1590 16 therapy therapy NN cord-005453-4057qib7 1590 17 to to IN cord-005453-4057qib7 1590 18 patients patient NNS cord-005453-4057qib7 1590 19 in in IN cord-005453-4057qib7 1590 20 early early JJ cord-005453-4057qib7 1590 21 2019 2019 CD cord-005453-4057qib7 1590 22 . . . cord-005453-4057qib7 1591 1 On on IN cord-005453-4057qib7 1591 2 collating collate VBG cord-005453-4057qib7 1591 3 from from IN cord-005453-4057qib7 1591 4 the the DT cord-005453-4057qib7 1591 5 leading lead VBG cord-005453-4057qib7 1591 6 consultant consultant NN cord-005453-4057qib7 1591 7 on on IN cord-005453-4057qib7 1591 8 the the DT cord-005453-4057qib7 1591 9 ward ward NN cord-005453-4057qib7 1591 10 and and CC cord-005453-4057qib7 1591 11 fellow fellow JJ cord-005453-4057qib7 1591 12 nursing nursing NN cord-005453-4057qib7 1591 13 team team NN cord-005453-4057qib7 1591 14 members member NNS cord-005453-4057qib7 1591 15 it -PRON- PRP cord-005453-4057qib7 1591 16 was be VBD cord-005453-4057qib7 1591 17 apparent apparent JJ cord-005453-4057qib7 1591 18 that that IN cord-005453-4057qib7 1591 19 an an DT cord-005453-4057qib7 1591 20 effective effective JJ cord-005453-4057qib7 1591 21 way way NN cord-005453-4057qib7 1591 22 at at IN cord-005453-4057qib7 1591 23 managing manage VBG cord-005453-4057qib7 1591 24 patients patient NNS cord-005453-4057qib7 1591 25 post post VBP cord-005453-4057qib7 1591 26 CAR car NN cord-005453-4057qib7 1591 27 T T NNP cord-005453-4057qib7 1591 28 - - HYPH cord-005453-4057qib7 1591 29 Cell cell NN cord-005453-4057qib7 1591 30 therapy therapy NN cord-005453-4057qib7 1591 31 side side NN cord-005453-4057qib7 1591 32 effects effect NNS cord-005453-4057qib7 1591 33 is be VBZ cord-005453-4057qib7 1591 34 to to TO cord-005453-4057qib7 1591 35 provide provide VB cord-005453-4057qib7 1591 36 an an DT cord-005453-4057qib7 1591 37 educational educational JJ cord-005453-4057qib7 1591 38 and and CC cord-005453-4057qib7 1591 39 informative informative JJ cord-005453-4057qib7 1591 40 poster poster NN cord-005453-4057qib7 1591 41 depicting depict VBG cord-005453-4057qib7 1591 42 a a DT cord-005453-4057qib7 1591 43 flow flow NN cord-005453-4057qib7 1591 44 chart chart NN cord-005453-4057qib7 1591 45 that that WDT cord-005453-4057qib7 1591 46 will will MD cord-005453-4057qib7 1591 47 aid aid VB cord-005453-4057qib7 1591 48 the the DT cord-005453-4057qib7 1591 49 practitioner practitioner NN cord-005453-4057qib7 1591 50 to to TO cord-005453-4057qib7 1591 51 recognise recognise VB cord-005453-4057qib7 1591 52 and and CC cord-005453-4057qib7 1591 53 effectively effectively RB cord-005453-4057qib7 1591 54 treat treat VB cord-005453-4057qib7 1591 55 / / SYM cord-005453-4057qib7 1591 56 manage manage VB cord-005453-4057qib7 1591 57 a a DT cord-005453-4057qib7 1591 58 patient patient NN cord-005453-4057qib7 1591 59 with with IN cord-005453-4057qib7 1591 60 CRS CRS NNP cord-005453-4057qib7 1591 61 symptoms symptom NNS cord-005453-4057qib7 1591 62 . . . cord-005453-4057qib7 1592 1 Results result NNS cord-005453-4057qib7 1592 2 : : : cord-005453-4057qib7 1593 1 None none NN cord-005453-4057qib7 1593 2 as as IN cord-005453-4057qib7 1593 3 of of IN cord-005453-4057qib7 1593 4 yet yet RB cord-005453-4057qib7 1593 5 as as IN cord-005453-4057qib7 1593 6 this this DT cord-005453-4057qib7 1593 7 is be VBZ cord-005453-4057qib7 1593 8 a a DT cord-005453-4057qib7 1593 9 prospective prospective JJ cord-005453-4057qib7 1593 10 tool tool NN cord-005453-4057qib7 1593 11 ready ready JJ cord-005453-4057qib7 1593 12 for for IN cord-005453-4057qib7 1593 13 our -PRON- PRP$ cord-005453-4057qib7 1593 14 first first JJ cord-005453-4057qib7 1593 15 patient patient NN cord-005453-4057qib7 1593 16 in in IN cord-005453-4057qib7 1593 17 early early JJ cord-005453-4057qib7 1593 18 2019 2019 CD cord-005453-4057qib7 1593 19 Conclusions conclusion NNS cord-005453-4057qib7 1593 20 : : : cord-005453-4057qib7 1594 1 Through through IN cord-005453-4057qib7 1594 2 continuing continue VBG cord-005453-4057qib7 1594 3 reading reading NN cord-005453-4057qib7 1594 4 and and CC cord-005453-4057qib7 1594 5 study study NN cord-005453-4057qib7 1594 6 days day NNS cord-005453-4057qib7 1594 7 prior prior RB cord-005453-4057qib7 1594 8 to to IN cord-005453-4057qib7 1594 9 the the DT cord-005453-4057qib7 1594 10 ward ward NN cord-005453-4057qib7 1594 11 receiving receive VBG cord-005453-4057qib7 1594 12 its -PRON- PRP$ cord-005453-4057qib7 1594 13 first first JJ cord-005453-4057qib7 1594 14 CAR car NN cord-005453-4057qib7 1594 15 T T NNP cord-005453-4057qib7 1594 16 - - HYPH cord-005453-4057qib7 1594 17 Cell cell NN cord-005453-4057qib7 1594 18 patient patient NN cord-005453-4057qib7 1594 19 it -PRON- PRP cord-005453-4057qib7 1594 20 is be VBZ cord-005453-4057qib7 1594 21 increasingly increasingly RB cord-005453-4057qib7 1594 22 important important JJ cord-005453-4057qib7 1594 23 that that IN cord-005453-4057qib7 1594 24 the the DT cord-005453-4057qib7 1594 25 entire entire JJ cord-005453-4057qib7 1594 26 multi multi JJ cord-005453-4057qib7 1594 27 disciplinary disciplinary JJ cord-005453-4057qib7 1594 28 team team NN cord-005453-4057qib7 1594 29 recognise recognise VBP cord-005453-4057qib7 1594 30 CRS CRS NNP cord-005453-4057qib7 1594 31 and and CC cord-005453-4057qib7 1594 32 understand understand VB cord-005453-4057qib7 1594 33 the the DT cord-005453-4057qib7 1594 34 importance importance NN cord-005453-4057qib7 1594 35 of of IN cord-005453-4057qib7 1594 36 early early JJ cord-005453-4057qib7 1594 37 detection detection NN cord-005453-4057qib7 1594 38 , , , cord-005453-4057qib7 1594 39 careful careful JJ cord-005453-4057qib7 1594 40 monitoring monitoring NN cord-005453-4057qib7 1594 41 and and CC cord-005453-4057qib7 1594 42 early early JJ cord-005453-4057qib7 1594 43 intervention intervention NN cord-005453-4057qib7 1594 44 . . . cord-005453-4057qib7 1595 1 Background background NN cord-005453-4057qib7 1595 2 : : : cord-005453-4057qib7 1596 1 Allogeneic allogeneic IN cord-005453-4057qib7 1596 2 stem stem VBP cord-005453-4057qib7 1596 3 cell cell NN cord-005453-4057qib7 1596 4 transplantation transplantation NN cord-005453-4057qib7 1596 5 ( ( -LRB- cord-005453-4057qib7 1596 6 alloSCT alloSCT NNP cord-005453-4057qib7 1596 7 ) ) -RRB- cord-005453-4057qib7 1596 8 is be VBZ cord-005453-4057qib7 1596 9 the the DT cord-005453-4057qib7 1596 10 only only JJ cord-005453-4057qib7 1596 11 curative curative JJ cord-005453-4057qib7 1596 12 procedure procedure NN cord-005453-4057qib7 1596 13 for for IN cord-005453-4057qib7 1596 14 primary primary JJ cord-005453-4057qib7 1596 15 and and CC cord-005453-4057qib7 1596 16 secondary secondary JJ cord-005453-4057qib7 1596 17 myelofibrosis myelofibrosis NN cord-005453-4057qib7 1596 18 ( ( -LRB- cord-005453-4057qib7 1596 19 PMF PMF NNP cord-005453-4057qib7 1596 20 , , , cord-005453-4057qib7 1596 21 SMF SMF NNP cord-005453-4057qib7 1596 22 ) ) -RRB- cord-005453-4057qib7 1596 23 . . . cord-005453-4057qib7 1597 1 Elderly elderly JJ cord-005453-4057qib7 1597 2 people people NNS cord-005453-4057qib7 1597 3 are be VBP cord-005453-4057qib7 1597 4 mainly mainly RB cord-005453-4057qib7 1597 5 affected affect VBN cord-005453-4057qib7 1597 6 , , , cord-005453-4057qib7 1597 7 limiting limit VBG cord-005453-4057qib7 1597 8 the the DT cord-005453-4057qib7 1597 9 feasibility feasibility NN cord-005453-4057qib7 1597 10 of of IN cord-005453-4057qib7 1597 11 intensive intensive JJ cord-005453-4057qib7 1597 12 myeloablative myeloablative JJ cord-005453-4057qib7 1597 13 chemotherapy chemotherapy NN cord-005453-4057qib7 1597 14 regimens regimen NNS cord-005453-4057qib7 1597 15 . . . cord-005453-4057qib7 1598 1 The the DT cord-005453-4057qib7 1598 2 introduction introduction NN cord-005453-4057qib7 1598 3 of of IN cord-005453-4057qib7 1598 4 reduced reduce VBN cord-005453-4057qib7 1598 5 - - HYPH cord-005453-4057qib7 1598 6 intensity intensity NN cord-005453-4057qib7 1598 7 conditioning conditioning NN cord-005453-4057qib7 1598 8 ( ( -LRB- cord-005453-4057qib7 1598 9 RIC RIC NNP cord-005453-4057qib7 1598 10 ) ) -RRB- cord-005453-4057qib7 1598 11 made make VBD cord-005453-4057qib7 1598 12 alloSCT alloSCT NNP cord-005453-4057qib7 1598 13 feasible feasible JJ cord-005453-4057qib7 1598 14 and and CC cord-005453-4057qib7 1598 15 effective effective JJ cord-005453-4057qib7 1598 16 for for IN cord-005453-4057qib7 1598 17 old old JJ cord-005453-4057qib7 1598 18 patients patient NNS cord-005453-4057qib7 1598 19 . . . cord-005453-4057qib7 1599 1 Nevertheless nevertheless RB cord-005453-4057qib7 1599 2 , , , cord-005453-4057qib7 1599 3 the the DT cord-005453-4057qib7 1599 4 incidence incidence NN cord-005453-4057qib7 1599 5 of of IN cord-005453-4057qib7 1599 6 PMF PMF NNP cord-005453-4057qib7 1599 7 and and CC cord-005453-4057qib7 1599 8 SMF SMF NNP cord-005453-4057qib7 1599 9 is be VBZ cord-005453-4057qib7 1599 10 not not RB cord-005453-4057qib7 1599 11 negligible negligible JJ cord-005453-4057qib7 1599 12 in in IN cord-005453-4057qib7 1599 13 young young JJ cord-005453-4057qib7 1599 14 patients patient NNS cord-005453-4057qib7 1599 15 , , , cord-005453-4057qib7 1599 16 theoretically theoretically RB cord-005453-4057qib7 1599 17 able able JJ cord-005453-4057qib7 1599 18 to to TO cord-005453-4057qib7 1599 19 tolerate tolerate VB cord-005453-4057qib7 1599 20 also also RB cord-005453-4057qib7 1599 21 high high JJ cord-005453-4057qib7 1599 22 - - HYPH cord-005453-4057qib7 1599 23 intensity intensity NN cord-005453-4057qib7 1599 24 therapy therapy NN cord-005453-4057qib7 1599 25 . . . cord-005453-4057qib7 1600 1 Very very RB cord-005453-4057qib7 1600 2 few few JJ cord-005453-4057qib7 1600 3 data datum NNS cord-005453-4057qib7 1600 4 are be VBP cord-005453-4057qib7 1600 5 available available JJ cord-005453-4057qib7 1600 6 about about IN cord-005453-4057qib7 1600 7 the the DT cord-005453-4057qib7 1600 8 efficacy efficacy NN cord-005453-4057qib7 1600 9 of of IN cord-005453-4057qib7 1600 10 RIC RIC NNP cord-005453-4057qib7 1600 11 - - HYPH cord-005453-4057qib7 1600 12 alloSCT alloSCT NNP cord-005453-4057qib7 1600 13 in in IN cord-005453-4057qib7 1600 14 the the DT cord-005453-4057qib7 1600 15 particular particular JJ cord-005453-4057qib7 1600 16 setting setting NN cord-005453-4057qib7 1600 17 of of IN cord-005453-4057qib7 1600 18 young young JJ cord-005453-4057qib7 1600 19 - - HYPH cord-005453-4057qib7 1600 20 aged aged JJ cord-005453-4057qib7 1600 21 MF MF NNP cord-005453-4057qib7 1600 22 patients patient NNS cord-005453-4057qib7 1600 23 . . . cord-005453-4057qib7 1601 1 Methods method NNS cord-005453-4057qib7 1601 2 : : : cord-005453-4057qib7 1602 1 This this DT cord-005453-4057qib7 1602 2 study study NN cord-005453-4057qib7 1602 3 includes include VBZ cord-005453-4057qib7 1602 4 56 56 CD cord-005453-4057qib7 1602 5 Myelofibrosis Myelofibrosis NNP cord-005453-4057qib7 1602 6 young young JJ cord-005453-4057qib7 1602 7 patients patient NNS cord-005453-4057qib7 1602 8 ( ( -LRB- cord-005453-4057qib7 1602 9 age age NN cord-005453-4057qib7 1602 10 < < XX cord-005453-4057qib7 1602 11 55y 55y CD cord-005453-4057qib7 1602 12 ) ) -RRB- cord-005453-4057qib7 1602 13 who who WP cord-005453-4057qib7 1602 14 received receive VBD cord-005453-4057qib7 1602 15 alloSCT allosct NN cord-005453-4057qib7 1602 16 between between IN cord-005453-4057qib7 1602 17 2002 2002 CD cord-005453-4057qib7 1602 18 and and CC cord-005453-4057qib7 1602 19 2016 2016 CD cord-005453-4057qib7 1602 20 at at IN cord-005453-4057qib7 1602 21 the the DT cord-005453-4057qib7 1602 22 University University NNP cord-005453-4057qib7 1602 23 Hospital Hospital NNP cord-005453-4057qib7 1602 24 Hamburg Hamburg NNP cord-005453-4057qib7 1602 25 / / SYM cord-005453-4057qib7 1602 26 Germany Germany NNP cord-005453-4057qib7 1602 27 . . . cord-005453-4057qib7 1603 1 Four four CD cord-005453-4057qib7 1603 2 patients patient NNS cord-005453-4057qib7 1603 3 were be VBD cord-005453-4057qib7 1603 4 previously previously RB cord-005453-4057qib7 1603 5 splenectomized splenectomize VBN cord-005453-4057qib7 1603 6 . . . cord-005453-4057qib7 1604 1 Patients patient NNS cord-005453-4057qib7 1604 2 mostly mostly RB cord-005453-4057qib7 1604 3 fall fall VBP cord-005453-4057qib7 1604 4 into into IN cord-005453-4057qib7 1604 5 intermediate intermediate JJ cord-005453-4057qib7 1604 6 risk risk NN cord-005453-4057qib7 1604 7 groups group NNS cord-005453-4057qib7 1604 8 according accord VBG cord-005453-4057qib7 1604 9 to to IN cord-005453-4057qib7 1604 10 DIPSS DIPSS NNP cord-005453-4057qib7 1604 11 . . . cord-005453-4057qib7 1605 1 Four four CD cord-005453-4057qib7 1605 2 patients patient NNS cord-005453-4057qib7 1605 3 belonged belong VBD cord-005453-4057qib7 1605 4 to to IN cord-005453-4057qib7 1605 5 the the DT cord-005453-4057qib7 1605 6 high high JJ cord-005453-4057qib7 1605 7 - - HYPH cord-005453-4057qib7 1605 8 risk risk NN cord-005453-4057qib7 1605 9 triple triple JJ cord-005453-4057qib7 1605 10 - - HYPH cord-005453-4057qib7 1605 11 negative negative JJ cord-005453-4057qib7 1605 12 category category NN cord-005453-4057qib7 1605 13 ( ( -LRB- cord-005453-4057qib7 1605 14 JAK2 JAK2 NNP cord-005453-4057qib7 1605 15 / / SYM cord-005453-4057qib7 1605 16 CALR CALR NNP cord-005453-4057qib7 1605 17 / / SYM cord-005453-4057qib7 1605 18 MPL- MPL- NNP cord-005453-4057qib7 1605 19 ) ) -RRB- cord-005453-4057qib7 1605 20 . . . cord-005453-4057qib7 1606 1 ASXL1-mut ASXL1-mut NNP cord-005453-4057qib7 1606 2 was be VBD cord-005453-4057qib7 1606 3 tested test VBN cord-005453-4057qib7 1606 4 in in IN cord-005453-4057qib7 1606 5 50 50 CD cord-005453-4057qib7 1606 6 patients patient NNS cord-005453-4057qib7 1606 7 ( ( -LRB- cord-005453-4057qib7 1606 8 pos pos NNP cord-005453-4057qib7 1606 9 : : : cord-005453-4057qib7 1606 10 17 17 CD cord-005453-4057qib7 1606 11 ) ) -RRB- cord-005453-4057qib7 1606 12 . . . cord-005453-4057qib7 1607 1 In in IN cord-005453-4057qib7 1607 2 96 96 CD cord-005453-4057qib7 1607 3 % % NN cord-005453-4057qib7 1607 4 graft graft NN cord-005453-4057qib7 1607 5 source source NN cord-005453-4057qib7 1607 6 was be VBD cord-005453-4057qib7 1607 7 PBSC PBSC NNP cord-005453-4057qib7 1607 8 , , , cord-005453-4057qib7 1607 9 2 2 CD cord-005453-4057qib7 1607 10 patients patient NNS cord-005453-4057qib7 1607 11 received receive VBD cord-005453-4057qib7 1607 12 BMSC BMSC NNP cord-005453-4057qib7 1607 13 . . . cord-005453-4057qib7 1608 1 Only only RB cord-005453-4057qib7 1608 2 30 30 CD cord-005453-4057qib7 1608 3 % % NN cord-005453-4057qib7 1608 4 of of IN cord-005453-4057qib7 1608 5 patients patient NNS cord-005453-4057qib7 1608 6 had have VBD cord-005453-4057qib7 1608 7 a a DT cord-005453-4057qib7 1608 8 10/10 10/10 CD cord-005453-4057qib7 1608 9 HLA HLA NNP cord-005453-4057qib7 1608 10 - - HYPH cord-005453-4057qib7 1608 11 matched match VBN cord-005453-4057qib7 1608 12 sibling sibling NN cord-005453-4057qib7 1608 13 , , , cord-005453-4057qib7 1608 14 the the DT cord-005453-4057qib7 1608 15 others other NNS cord-005453-4057qib7 1608 16 were be VBD cord-005453-4057qib7 1608 17 transplanted transplant VBN cord-005453-4057qib7 1608 18 from from IN cord-005453-4057qib7 1608 19 fully fully RB cord-005453-4057qib7 1608 20 - - HYPH cord-005453-4057qib7 1608 21 matched match VBN cord-005453-4057qib7 1608 22 ( ( -LRB- cord-005453-4057qib7 1608 23 36 36 CD cord-005453-4057qib7 1608 24 % % NN cord-005453-4057qib7 1608 25 ) ) -RRB- cord-005453-4057qib7 1608 26 or or CC cord-005453-4057qib7 1608 27 partially partially RB cord-005453-4057qib7 1608 28 - - HYPH cord-005453-4057qib7 1608 29 matched match VBN cord-005453-4057qib7 1608 30 ( ( -LRB- cord-005453-4057qib7 1608 31 34 34 CD cord-005453-4057qib7 1608 32 % % NN cord-005453-4057qib7 1608 33 ) ) -RRB- cord-005453-4057qib7 1608 34 unrelated unrelated JJ cord-005453-4057qib7 1608 35 donor donor NN cord-005453-4057qib7 1608 36 . . . cord-005453-4057qib7 1609 1 All all DT cord-005453-4057qib7 1609 2 transplants transplant NNS cord-005453-4057qib7 1609 3 were be VBD cord-005453-4057qib7 1609 4 conditioned condition VBN cord-005453-4057qib7 1609 5 according accord VBG cord-005453-4057qib7 1609 6 the the DT cord-005453-4057qib7 1609 7 EBMT EBMT NNP cord-005453-4057qib7 1609 8 protocol protocol NN cord-005453-4057qib7 1609 9 with with IN cord-005453-4057qib7 1609 10 Busulfan Busulfan NNP cord-005453-4057qib7 1609 11 ( ( -LRB- cord-005453-4057qib7 1609 12 10 10 CD cord-005453-4057qib7 1609 13 mg mg NNP cord-005453-4057qib7 1609 14 / / SYM cord-005453-4057qib7 1609 15 Kg Kg NNP cord-005453-4057qib7 1609 16 PO PO NNP cord-005453-4057qib7 1609 17 or or CC cord-005453-4057qib7 1609 18 8 8 CD cord-005453-4057qib7 1609 19 mg mg NNP cord-005453-4057qib7 1609 20 / / SYM cord-005453-4057qib7 1609 21 Kg Kg NNP cord-005453-4057qib7 1609 22 IV IV NNP cord-005453-4057qib7 1609 23 ) ) -RRB- cord-005453-4057qib7 1609 24 , , , cord-005453-4057qib7 1609 25 Fludarabine Fludarabine NNP cord-005453-4057qib7 1609 26 ( ( -LRB- cord-005453-4057qib7 1609 27 150 150 CD cord-005453-4057qib7 1609 28 mg mg NNP cord-005453-4057qib7 1609 29 / / SYM cord-005453-4057qib7 1609 30 m2 m2 NNP cord-005453-4057qib7 1609 31 ) ) -RRB- cord-005453-4057qib7 1609 32 , , , cord-005453-4057qib7 1609 33 ATLG ATLG NNP cord-005453-4057qib7 1609 34 ( ( -LRB- cord-005453-4057qib7 1609 35 Grafalon Grafalon NNP cord-005453-4057qib7 1609 36 ® ® . cord-005453-4057qib7 1609 37 Neovii Neovii NNP cord-005453-4057qib7 1609 38 , , , cord-005453-4057qib7 1609 39 Germany Germany NNP cord-005453-4057qib7 1609 40 ) ) -RRB- cord-005453-4057qib7 1609 41 administered administer VBD cord-005453-4057qib7 1609 42 in in IN cord-005453-4057qib7 1609 43 3 3 CD cord-005453-4057qib7 1609 44 days day NNS cord-005453-4057qib7 1609 45 at at IN cord-005453-4057qib7 1609 46 a a DT cord-005453-4057qib7 1609 47 dose dose NN cord-005453-4057qib7 1609 48 of of IN cord-005453-4057qib7 1609 49 20 20 CD cord-005453-4057qib7 1609 50 mg mg NNP cord-005453-4057qib7 1609 51 / / SYM cord-005453-4057qib7 1609 52 Kg Kg NNP cord-005453-4057qib7 1609 53 die die VBP cord-005453-4057qib7 1609 54 for for IN cord-005453-4057qib7 1609 55 MUD mud NN cord-005453-4057qib7 1609 56 , , , cord-005453-4057qib7 1609 57 10 10 CD cord-005453-4057qib7 1609 58 mg mg NNP cord-005453-4057qib7 1609 59 / / SYM cord-005453-4057qib7 1609 60 Kg Kg NNP cord-005453-4057qib7 1609 61 die die VBP cord-005453-4057qib7 1609 62 for for IN cord-005453-4057qib7 1609 63 MRD MRD NNP cord-005453-4057qib7 1609 64 transplants transplant NNS cord-005453-4057qib7 1609 65 , , , cord-005453-4057qib7 1609 66 followed follow VBN cord-005453-4057qib7 1609 67 by by IN cord-005453-4057qib7 1609 68 CylosporinA cylosporina RB cord-005453-4057qib7 1609 69 , , , cord-005453-4057qib7 1609 70 and and CC cord-005453-4057qib7 1609 71 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 1609 72 in in IN cord-005453-4057qib7 1609 73 the the DT cord-005453-4057qib7 1609 74 first first JJ cord-005453-4057qib7 1609 75 28 28 CD cord-005453-4057qib7 1609 76 days day NNS cord-005453-4057qib7 1609 77 . . . cord-005453-4057qib7 1610 1 Results result NNS cord-005453-4057qib7 1610 2 : : : cord-005453-4057qib7 1611 1 Engraftment Engraftment NNP cord-005453-4057qib7 1611 2 rate rate NN cord-005453-4057qib7 1611 3 was be VBD cord-005453-4057qib7 1611 4 98 98 CD cord-005453-4057qib7 1611 5 % % NN cord-005453-4057qib7 1611 6 , , , cord-005453-4057qib7 1611 7 median median JJ cord-005453-4057qib7 1611 8 neutrophil neutrophil NN cord-005453-4057qib7 1611 9 engraftment engraftment NN cord-005453-4057qib7 1611 10 time time NN cord-005453-4057qib7 1611 11 15 15 CD cord-005453-4057qib7 1611 12 days day NNS cord-005453-4057qib7 1611 13 . . . cord-005453-4057qib7 1612 1 Platelet platelet NN cord-005453-4057qib7 1612 2 engraftment engraftment NN cord-005453-4057qib7 1612 3 was be VBD cord-005453-4057qib7 1612 4 reached reach VBN cord-005453-4057qib7 1612 5 by by IN cord-005453-4057qib7 1612 6 51 51 CD cord-005453-4057qib7 1612 7 patients patient NNS cord-005453-4057qib7 1612 8 ( ( -LRB- cord-005453-4057qib7 1612 9 91 91 CD cord-005453-4057qib7 1612 10 % % NN cord-005453-4057qib7 1612 11 , , , cord-005453-4057qib7 1612 12 median median JJ cord-005453-4057qib7 1612 13 19 19 CD cord-005453-4057qib7 1612 14 days day NNS cord-005453-4057qib7 1612 15 ) ) -RRB- cord-005453-4057qib7 1612 16 . . . cord-005453-4057qib7 1613 1 Four four CD cord-005453-4057qib7 1613 2 patients patient NNS cord-005453-4057qib7 1613 3 ( ( -LRB- cord-005453-4057qib7 1613 4 7 7 CD cord-005453-4057qib7 1613 5 % % NN cord-005453-4057qib7 1613 6 ) ) -RRB- cord-005453-4057qib7 1613 7 developed develop VBD cord-005453-4057qib7 1613 8 poor poor JJ cord-005453-4057qib7 1613 9 graft graft NN cord-005453-4057qib7 1613 10 function function NN cord-005453-4057qib7 1613 11 , , , cord-005453-4057qib7 1613 12 successfully successfully RB cord-005453-4057qib7 1613 13 treated treat VBN cord-005453-4057qib7 1613 14 with with IN cord-005453-4057qib7 1613 15 CD34 CD34 NNP cord-005453-4057qib7 1613 16 + + SYM cord-005453-4057qib7 1613 17 selected select VBN cord-005453-4057qib7 1613 18 PBSC PBSC NNP cord-005453-4057qib7 1613 19 - - HYPH cord-005453-4057qib7 1613 20 boost boost NN cord-005453-4057qib7 1613 21 . . . cord-005453-4057qib7 1614 1 After after IN cord-005453-4057qib7 1614 2 a a DT cord-005453-4057qib7 1614 3 median median NN cord-005453-4057qib7 1614 4 follow follow NN cord-005453-4057qib7 1614 5 up up IN cord-005453-4057qib7 1614 6 of of IN cord-005453-4057qib7 1614 7 8.6 8.6 CD cord-005453-4057qib7 1614 8 years year NNS cord-005453-4057qib7 1614 9 , , , cord-005453-4057qib7 1614 10 estimated estimate VBN cord-005453-4057qib7 1614 11 5y 5y NN cord-005453-4057qib7 1614 12 - - HYPH cord-005453-4057qib7 1614 13 PFS PFS NNP cord-005453-4057qib7 1614 14 and and CC cord-005453-4057qib7 1614 15 OS OS NNP cord-005453-4057qib7 1614 16 were be VBD cord-005453-4057qib7 1614 17 68 68 CD cord-005453-4057qib7 1614 18 % % NN cord-005453-4057qib7 1614 19 and and CC cord-005453-4057qib7 1614 20 82 82 CD cord-005453-4057qib7 1614 21 % % NN cord-005453-4057qib7 1614 22 respectively respectively RB cord-005453-4057qib7 1614 23 . . . cord-005453-4057qib7 1615 1 DIPSS dipss NN cord-005453-4057qib7 1615 2 - - HYPH cord-005453-4057qib7 1615 3 risk risk NN cord-005453-4057qib7 1615 4 and and CC cord-005453-4057qib7 1615 5 donor donor NN cord-005453-4057qib7 1615 6 HLA HLA NNP cord-005453-4057qib7 1615 7 - - HYPH cord-005453-4057qib7 1615 8 matching matching NN cord-005453-4057qib7 1615 9 resulted result VBD cord-005453-4057qib7 1615 10 the the DT cord-005453-4057qib7 1615 11 only only JJ cord-005453-4057qib7 1615 12 significant significant JJ cord-005453-4057qib7 1615 13 impacting impact VBG cord-005453-4057qib7 1615 14 factors factor NNS cord-005453-4057qib7 1615 15 on on IN cord-005453-4057qib7 1615 16 OS OS NNP cord-005453-4057qib7 1615 17 . . . cord-005453-4057qib7 1616 1 Neither neither DT cord-005453-4057qib7 1616 2 cytogenetic cytogenetic JJ cord-005453-4057qib7 1616 3 nor nor CC cord-005453-4057qib7 1616 4 molecular molecular JJ cord-005453-4057qib7 1616 5 abnormalities abnormality NNS cord-005453-4057qib7 1616 6 were be VBD cord-005453-4057qib7 1616 7 significantly significantly RB cord-005453-4057qib7 1616 8 related relate VBN cord-005453-4057qib7 1616 9 to to IN cord-005453-4057qib7 1616 10 OS OS NNP cord-005453-4057qib7 1616 11 . . . cord-005453-4057qib7 1617 1 Twenty twenty CD cord-005453-4057qib7 1617 2 - - HYPH cord-005453-4057qib7 1617 3 five five CD cord-005453-4057qib7 1617 4 patients patient NNS cord-005453-4057qib7 1617 5 ( ( -LRB- cord-005453-4057qib7 1617 6 44 44 CD cord-005453-4057qib7 1617 7 % % NN cord-005453-4057qib7 1617 8 ) ) -RRB- cord-005453-4057qib7 1617 9 experienced experience VBD cord-005453-4057qib7 1617 10 aGVHD aGVHD NNP cord-005453-4057qib7 1617 11 grade grade NN cord-005453-4057qib7 1617 12 > > XX cord-005453-4057qib7 1618 1 1 1 LS cord-005453-4057qib7 1618 2 . . . cord-005453-4057qib7 1619 1 C C NNP cord-005453-4057qib7 1619 2 - - HYPH cord-005453-4057qib7 1619 3 GVHD GVHD NNP cord-005453-4057qib7 1619 4 was be VBD cord-005453-4057qib7 1619 5 observed observe VBN cord-005453-4057qib7 1619 6 in in IN cord-005453-4057qib7 1619 7 34 34 CD cord-005453-4057qib7 1619 8 patients patient NNS cord-005453-4057qib7 1619 9 ( ( -LRB- cord-005453-4057qib7 1619 10 65 65 CD cord-005453-4057qib7 1619 11 % % NN cord-005453-4057qib7 1619 12 ) ) -RRB- cord-005453-4057qib7 1619 13 , , , cord-005453-4057qib7 1619 14 mostly mostly RB cord-005453-4057qib7 1619 15 ( ( -LRB- cord-005453-4057qib7 1619 16 82 82 CD cord-005453-4057qib7 1619 17 % % NN cord-005453-4057qib7 1619 18 ) ) -RRB- cord-005453-4057qib7 1619 19 beginning begin VBG cord-005453-4057qib7 1619 20 in in IN cord-005453-4057qib7 1619 21 the the DT cord-005453-4057qib7 1619 22 first first JJ cord-005453-4057qib7 1619 23 300 300 CD cord-005453-4057qib7 1619 24 days day NNS cord-005453-4057qib7 1619 25 after after IN cord-005453-4057qib7 1619 26 transplantation transplantation NN cord-005453-4057qib7 1619 27 . . . cord-005453-4057qib7 1620 1 Cumulative cumulative JJ cord-005453-4057qib7 1620 2 incidence incidence NN cord-005453-4057qib7 1620 3 of of IN cord-005453-4057qib7 1620 4 TRM TRM NNP cord-005453-4057qib7 1620 5 was be VBD cord-005453-4057qib7 1620 6 7 7 CD cord-005453-4057qib7 1620 7 % % NN cord-005453-4057qib7 1620 8 at at IN cord-005453-4057qib7 1620 9 1 1 CD cord-005453-4057qib7 1620 10 year year NN cord-005453-4057qib7 1620 11 , , , cord-005453-4057qib7 1620 12 with with IN cord-005453-4057qib7 1620 13 a a DT cord-005453-4057qib7 1620 14 plateau plateau NN cord-005453-4057qib7 1620 15 after after IN cord-005453-4057qib7 1620 16 the the DT cord-005453-4057qib7 1620 17 first first JJ cord-005453-4057qib7 1620 18 year year NN cord-005453-4057qib7 1621 1 ( ( -LRB- cord-005453-4057qib7 1621 2 5y 5y NNP cord-005453-4057qib7 1621 3 TRM TRM NNP cord-005453-4057qib7 1621 4 = = SYM cord-005453-4057qib7 1621 5 12 12 CD cord-005453-4057qib7 1621 6 % % NN cord-005453-4057qib7 1621 7 ) ) -RRB- cord-005453-4057qib7 1621 8 . . . cord-005453-4057qib7 1622 1 TRM TRM NNP cord-005453-4057qib7 1622 2 was be VBD cord-005453-4057qib7 1622 3 observed observe VBN cord-005453-4057qib7 1622 4 only only RB cord-005453-4057qib7 1622 5 in in IN cord-005453-4057qib7 1622 6 patients patient NNS cord-005453-4057qib7 1622 7 with with IN cord-005453-4057qib7 1622 8 maximal maximal JJ cord-005453-4057qib7 1622 9 grade grade NN cord-005453-4057qib7 1622 10 ( ( -LRB- cord-005453-4057qib7 1622 11 3 3 CD cord-005453-4057qib7 1622 12 ) ) -RRB- cord-005453-4057qib7 1622 13 of of IN cord-005453-4057qib7 1622 14 marrow marrow NN cord-005453-4057qib7 1622 15 fibrosis fibrosis NN cord-005453-4057qib7 1622 16 . . . cord-005453-4057qib7 1623 1 Furthermore furthermore RB cord-005453-4057qib7 1623 2 , , , cord-005453-4057qib7 1623 3 TRM TRM NNP cord-005453-4057qib7 1623 4 never never RB cord-005453-4057qib7 1623 5 occurred occur VBD cord-005453-4057qib7 1623 6 in in IN cord-005453-4057qib7 1623 7 previously previously RB cord-005453-4057qib7 1623 8 splenectomized splenectomize VBN cord-005453-4057qib7 1623 9 patients patient NNS cord-005453-4057qib7 1623 10 ( ( -LRB- cord-005453-4057qib7 1623 11 p=0.00 p=0.00 NNP cord-005453-4057qib7 1623 12 ) ) -RRB- cord-005453-4057qib7 1623 13 , , , cord-005453-4057qib7 1623 14 but but CC cord-005453-4057qib7 1623 15 no no DT cord-005453-4057qib7 1623 16 significant significant JJ cord-005453-4057qib7 1623 17 impact impact NN cord-005453-4057qib7 1623 18 from from IN cord-005453-4057qib7 1623 19 splenectomy splenectomy NN cord-005453-4057qib7 1623 20 on on IN cord-005453-4057qib7 1623 21 OS OS NNP cord-005453-4057qib7 1623 22 was be VBD cord-005453-4057qib7 1623 23 observed observe VBN cord-005453-4057qib7 1623 24 ( ( -LRB- cord-005453-4057qib7 1623 25 p=0.32 p=0.32 RB cord-005453-4057qib7 1623 26 ) ) -RRB- cord-005453-4057qib7 1623 27 . . . cord-005453-4057qib7 1624 1 After after IN cord-005453-4057qib7 1624 2 transplant transplant NN cord-005453-4057qib7 1624 3 , , , cord-005453-4057qib7 1624 4 11 11 CD cord-005453-4057qib7 1624 5 patients patient NNS cord-005453-4057qib7 1624 6 ( ( -LRB- cord-005453-4057qib7 1624 7 20 20 CD cord-005453-4057qib7 1624 8 % % NN cord-005453-4057qib7 1624 9 ) ) -RRB- cord-005453-4057qib7 1624 10 relapsed relapse VBN cord-005453-4057qib7 1624 11 : : : cord-005453-4057qib7 1624 12 1 1 CD cord-005453-4057qib7 1624 13 died die VBD cord-005453-4057qib7 1624 14 without without IN cord-005453-4057qib7 1624 15 any any DT cord-005453-4057qib7 1624 16 treatment treatment NN cord-005453-4057qib7 1624 17 because because IN cord-005453-4057qib7 1624 18 of of IN cord-005453-4057qib7 1624 19 infection infection NN cord-005453-4057qib7 1624 20 , , , cord-005453-4057qib7 1624 21 9 9 CD cord-005453-4057qib7 1624 22 received receive VBD cord-005453-4057qib7 1624 23 DLI DLI NNP cord-005453-4057qib7 1624 24 ( ( -LRB- cord-005453-4057qib7 1624 25 3 3 CD cord-005453-4057qib7 1624 26 durable durable JJ cord-005453-4057qib7 1624 27 CR CR NNP cord-005453-4057qib7 1624 28 ) ) -RRB- cord-005453-4057qib7 1624 29 , , , cord-005453-4057qib7 1624 30 7 7 CD cord-005453-4057qib7 1624 31 patients patient NNS cord-005453-4057qib7 1624 32 ( ( -LRB- cord-005453-4057qib7 1624 33 6 6 CD cord-005453-4057qib7 1624 34 after after IN cord-005453-4057qib7 1624 35 DLI DLI NNP cord-005453-4057qib7 1624 36 ) ) -RRB- cord-005453-4057qib7 1624 37 underwent undergo VBD cord-005453-4057qib7 1624 38 a a DT cord-005453-4057qib7 1624 39 second second JJ cord-005453-4057qib7 1624 40 alloSCT allosct NN cord-005453-4057qib7 1624 41 , , , cord-005453-4057qib7 1624 42 with with IN cord-005453-4057qib7 1624 43 long long JJ cord-005453-4057qib7 1624 44 - - HYPH cord-005453-4057qib7 1624 45 term term NN cord-005453-4057qib7 1624 46 survival survival NN cord-005453-4057qib7 1624 47 in in IN cord-005453-4057qib7 1624 48 5 5 CD cord-005453-4057qib7 1624 49 cases case NNS cord-005453-4057qib7 1624 50 . . . cord-005453-4057qib7 1625 1 Conclusions conclusion NNS cord-005453-4057qib7 1625 2 : : : cord-005453-4057qib7 1626 1 RIC RIC NNP cord-005453-4057qib7 1626 2 followed follow VBD cord-005453-4057qib7 1626 3 by by IN cord-005453-4057qib7 1626 4 allogeneic allogeneic NN cord-005453-4057qib7 1626 5 SCT SCT NNP cord-005453-4057qib7 1626 6 is be VBZ cord-005453-4057qib7 1626 7 a a DT cord-005453-4057qib7 1626 8 curative curative JJ cord-005453-4057qib7 1626 9 treatment treatment NN cord-005453-4057qib7 1626 10 approach approach NN cord-005453-4057qib7 1626 11 for for IN cord-005453-4057qib7 1626 12 younger young JJR cord-005453-4057qib7 1626 13 patients patient NNS cord-005453-4057qib7 1626 14 with with IN cord-005453-4057qib7 1626 15 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 1626 16 with with IN cord-005453-4057qib7 1626 17 a a DT cord-005453-4057qib7 1626 18 low low JJ cord-005453-4057qib7 1626 19 NRM NRM NNP cord-005453-4057qib7 1626 20 . . . cord-005453-4057qib7 1627 1 The the DT cord-005453-4057qib7 1627 2 most most RBS cord-005453-4057qib7 1627 3 important important JJ cord-005453-4057qib7 1627 4 outcome outcome NN cord-005453-4057qib7 1627 5 - - HYPH cord-005453-4057qib7 1627 6 determining determine VBG cord-005453-4057qib7 1627 7 factor factor NN cord-005453-4057qib7 1627 8 is be VBZ cord-005453-4057qib7 1627 9 donor donor NN cord-005453-4057qib7 1627 10 HLA HLA NNP cord-005453-4057qib7 1627 11 - - HYPH cord-005453-4057qib7 1627 12 matching matching NN cord-005453-4057qib7 1627 13 . . . cord-005453-4057qib7 1628 1 Interestingly interestingly RB cord-005453-4057qib7 1628 2 , , , cord-005453-4057qib7 1628 3 marrow marrow NN cord-005453-4057qib7 1628 4 high high JJ cord-005453-4057qib7 1628 5 grade grade NN cord-005453-4057qib7 1628 6 fibrosis fibrosis NN cord-005453-4057qib7 1628 7 showed show VBD cord-005453-4057qib7 1628 8 to to IN cord-005453-4057qib7 1628 9 significantly significantly RB cord-005453-4057qib7 1628 10 impact impact VB cord-005453-4057qib7 1628 11 TRM TRM NNP cord-005453-4057qib7 1628 12 . . . cord-005453-4057qib7 1629 1 Biological biological JJ cord-005453-4057qib7 1629 2 markers marker NNS cord-005453-4057qib7 1629 3 such such JJ cord-005453-4057qib7 1629 4 as as IN cord-005453-4057qib7 1629 5 ASXL1 asxl1 NN cord-005453-4057qib7 1629 6 mutation mutation NN cord-005453-4057qib7 1629 7 and and CC cord-005453-4057qib7 1629 8 cytogenetics cytogenetic NNS cord-005453-4057qib7 1629 9 , , , cord-005453-4057qib7 1629 10 largely largely RB cord-005453-4057qib7 1629 11 known know VBN cord-005453-4057qib7 1629 12 as as IN cord-005453-4057qib7 1629 13 highly highly RB cord-005453-4057qib7 1629 14 predictive predictive JJ cord-005453-4057qib7 1629 15 for for IN cord-005453-4057qib7 1629 16 poor poor JJ cord-005453-4057qib7 1629 17 prognosis prognosis NN cord-005453-4057qib7 1629 18 in in IN cord-005453-4057qib7 1629 19 the the DT cord-005453-4057qib7 1629 20 disease disease NN cord-005453-4057qib7 1629 21 natural natural JJ cord-005453-4057qib7 1629 22 course course NN cord-005453-4057qib7 1629 23 , , , cord-005453-4057qib7 1629 24 did do VBD cord-005453-4057qib7 1629 25 not not RB cord-005453-4057qib7 1629 26 show show VB cord-005453-4057qib7 1629 27 any any DT cord-005453-4057qib7 1629 28 impact impact NN cord-005453-4057qib7 1629 29 on on IN cord-005453-4057qib7 1629 30 survival survival NN cord-005453-4057qib7 1629 31 , , , cord-005453-4057qib7 1629 32 suggesting suggest VBG cord-005453-4057qib7 1629 33 that that IN cord-005453-4057qib7 1629 34 patients patient NNS cord-005453-4057qib7 1629 35 harboring harbor VBG cord-005453-4057qib7 1629 36 these these DT cord-005453-4057qib7 1629 37 abnormalities abnormality NNS cord-005453-4057qib7 1629 38 could could MD cord-005453-4057qib7 1629 39 get get VB cord-005453-4057qib7 1629 40 the the DT cord-005453-4057qib7 1629 41 greatest great JJS cord-005453-4057qib7 1629 42 benefit benefit NN cord-005453-4057qib7 1629 43 from from IN cord-005453-4057qib7 1629 44 alloSCT alloSCT NNP cord-005453-4057qib7 1629 45 . . . cord-005453-4057qib7 1630 1 Further further JJ cord-005453-4057qib7 1630 2 data datum NNS cord-005453-4057qib7 1630 3 collection collection NN cord-005453-4057qib7 1630 4 , , , cord-005453-4057qib7 1630 5 and and CC cord-005453-4057qib7 1630 6 a a DT cord-005453-4057qib7 1630 7 prospective prospective JJ cord-005453-4057qib7 1630 8 randomized randomized JJ cord-005453-4057qib7 1630 9 trial trial NN cord-005453-4057qib7 1630 10 are be VBP cord-005453-4057qib7 1630 11 needed need VBN cord-005453-4057qib7 1630 12 to to TO cord-005453-4057qib7 1630 13 confirm confirm VB cord-005453-4057qib7 1630 14 our -PRON- PRP$ cord-005453-4057qib7 1630 15 conclusion conclusion NN cord-005453-4057qib7 1630 16 . . . cord-005453-4057qib7 1631 1 Disclosure disclosure NN cord-005453-4057qib7 1631 2 : : : cord-005453-4057qib7 1631 3 Nothing nothing NN cord-005453-4057qib7 1631 4 to to TO cord-005453-4057qib7 1631 5 declare declare VB cord-005453-4057qib7 1631 6 P087 P087 NNP cord-005453-4057qib7 1631 7 Abstract Abstract NNP cord-005453-4057qib7 1631 8 already already RB cord-005453-4057qib7 1631 9 published publish VBN cord-005453-4057qib7 1631 10 . . . cord-005453-4057qib7 1632 1 Splenectomy Splenectomy NNP cord-005453-4057qib7 1632 2 as as IN cord-005453-4057qib7 1632 3 a a DT cord-005453-4057qib7 1632 4 risk risk NN cord-005453-4057qib7 1632 5 factor factor NN cord-005453-4057qib7 1632 6 for for IN cord-005453-4057qib7 1632 7 relapse relapse NN cord-005453-4057qib7 1632 8 after after IN cord-005453-4057qib7 1632 9 allogeneic allogeneic JJ cord-005453-4057qib7 1632 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 1632 11 stem stem NN cord-005453-4057qib7 1632 12 cell cell NN cord-005453-4057qib7 1632 13 transplantation transplantation NN cord-005453-4057qib7 1632 14 in in IN cord-005453-4057qib7 1632 15 patients patient NNS cord-005453-4057qib7 1632 16 with with IN cord-005453-4057qib7 1632 17 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 1632 18 -retrospective -retrospective IN cord-005453-4057qib7 1632 19 cohort cohort NN cord-005453-4057qib7 1632 20 study study NN cord-005453-4057qib7 1632 21 Background Background NNP cord-005453-4057qib7 1632 22 : : : cord-005453-4057qib7 1633 1 Splenectomy Splenectomy NNP cord-005453-4057qib7 1633 2 is be VBZ cord-005453-4057qib7 1633 3 a a DT cord-005453-4057qib7 1633 4 common common JJ cord-005453-4057qib7 1633 5 procedure procedure NN cord-005453-4057qib7 1633 6 in in IN cord-005453-4057qib7 1633 7 patients patient NNS cord-005453-4057qib7 1633 8 ( ( -LRB- cord-005453-4057qib7 1633 9 pts pts NNP cord-005453-4057qib7 1633 10 ) ) -RRB- cord-005453-4057qib7 1633 11 with with IN cord-005453-4057qib7 1633 12 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 1633 13 ( ( -LRB- cord-005453-4057qib7 1633 14 MF MF NNP cord-005453-4057qib7 1633 15 ) ) -RRB- cord-005453-4057qib7 1633 16 performed perform VBD cord-005453-4057qib7 1633 17 to to TO cord-005453-4057qib7 1633 18 achieve achieve VB cord-005453-4057qib7 1633 19 improvement improvement NN cord-005453-4057qib7 1633 20 in in IN cord-005453-4057qib7 1633 21 blood blood NN cord-005453-4057qib7 1633 22 cell cell NN cord-005453-4057qib7 1633 23 counts count NNS cord-005453-4057qib7 1633 24 and and CC cord-005453-4057qib7 1633 25 reduce reduce VB cord-005453-4057qib7 1633 26 B b NN cord-005453-4057qib7 1633 27 - - HYPH cord-005453-4057qib7 1633 28 symptoms symptom NNS cord-005453-4057qib7 1633 29 . . . cord-005453-4057qib7 1634 1 However however RB cord-005453-4057qib7 1634 2 , , , cord-005453-4057qib7 1634 3 it -PRON- PRP cord-005453-4057qib7 1634 4 has have VBZ cord-005453-4057qib7 1634 5 also also RB cord-005453-4057qib7 1634 6 been be VBN cord-005453-4057qib7 1634 7 shown show VBN cord-005453-4057qib7 1634 8 that that IN cord-005453-4057qib7 1634 9 splenectomy splenectomy NN cord-005453-4057qib7 1634 10 may may MD cord-005453-4057qib7 1634 11 adversely adversely RB cord-005453-4057qib7 1634 12 predispose predispose VB cord-005453-4057qib7 1634 13 to to TO cord-005453-4057qib7 1634 14 leukemic leukemic JJ cord-005453-4057qib7 1634 15 transformation transformation NN cord-005453-4057qib7 1634 16 in in IN cord-005453-4057qib7 1634 17 this this DT cord-005453-4057qib7 1634 18 setting setting NN cord-005453-4057qib7 1634 19 . . . cord-005453-4057qib7 1635 1 Aim aim VB cord-005453-4057qib7 1635 2 : : : cord-005453-4057qib7 1635 3 To to TO cord-005453-4057qib7 1635 4 evaluate evaluate VB cord-005453-4057qib7 1635 5 in in IN cord-005453-4057qib7 1635 6 a a DT cord-005453-4057qib7 1635 7 single single JJ cord-005453-4057qib7 1635 8 - - HYPH cord-005453-4057qib7 1635 9 center center NN cord-005453-4057qib7 1635 10 retrospective retrospective JJ cord-005453-4057qib7 1635 11 analysis analysis NN cord-005453-4057qib7 1635 12 the the DT cord-005453-4057qib7 1635 13 long long JJ cord-005453-4057qib7 1635 14 - - HYPH cord-005453-4057qib7 1635 15 term term NN cord-005453-4057qib7 1635 16 impact impact NN cord-005453-4057qib7 1635 17 of of IN cord-005453-4057qib7 1635 18 pre pre JJ cord-005453-4057qib7 1635 19 - - JJ cord-005453-4057qib7 1635 20 or or CC cord-005453-4057qib7 1635 21 post post JJ cord-005453-4057qib7 1635 22 - - JJ cord-005453-4057qib7 1635 23 transplant transplant JJ cord-005453-4057qib7 1635 24 splenectomy splenectomy NN cord-005453-4057qib7 1635 25 on on IN cord-005453-4057qib7 1635 26 transplant transplant NN cord-005453-4057qib7 1635 27 outcome outcome NN cord-005453-4057qib7 1635 28 regarding regard VBG cord-005453-4057qib7 1635 29 overall overall JJ cord-005453-4057qib7 1635 30 survival survival NN cord-005453-4057qib7 1635 31 and and CC cord-005453-4057qib7 1635 32 relapse relapse NN cord-005453-4057qib7 1635 33 risk risk NN cord-005453-4057qib7 1635 34 . . . cord-005453-4057qib7 1636 1 Methods method NNS cord-005453-4057qib7 1636 2 : : : cord-005453-4057qib7 1637 1 This this DT cord-005453-4057qib7 1637 2 retrospective retrospective JJ cord-005453-4057qib7 1637 3 analysis analysis NN cord-005453-4057qib7 1637 4 comprises comprise VBZ cord-005453-4057qib7 1637 5 the the DT cord-005453-4057qib7 1637 6 data datum NNS cord-005453-4057qib7 1637 7 of of IN cord-005453-4057qib7 1637 8 163 163 CD cord-005453-4057qib7 1637 9 pts pt NNS cord-005453-4057qib7 1637 10 ( ( -LRB- cord-005453-4057qib7 1637 11 93 93 CD cord-005453-4057qib7 1637 12 male male NN cord-005453-4057qib7 1637 13 and and CC cord-005453-4057qib7 1637 14 70 70 CD cord-005453-4057qib7 1637 15 female female NN cord-005453-4057qib7 1637 16 ) ) -RRB- cord-005453-4057qib7 1637 17 with with IN cord-005453-4057qib7 1637 18 primary primary JJ cord-005453-4057qib7 1637 19 ( ( -LRB- cord-005453-4057qib7 1637 20 n=108 n=108 NNP cord-005453-4057qib7 1637 21 ) ) -RRB- cord-005453-4057qib7 1637 22 or or CC cord-005453-4057qib7 1637 23 secondary secondary JJ cord-005453-4057qib7 1637 24 ( ( -LRB- cord-005453-4057qib7 1637 25 n=55 n=55 JJ cord-005453-4057qib7 1637 26 ) ) -RRB- cord-005453-4057qib7 1637 27 MF mf NN cord-005453-4057qib7 1637 28 after after IN cord-005453-4057qib7 1637 29 allo allo NN cord-005453-4057qib7 1637 30 - - HYPH cord-005453-4057qib7 1637 31 HSCT HSCT NNP cord-005453-4057qib7 1637 32 from from IN cord-005453-4057qib7 1637 33 HLA HLA NNP cord-005453-4057qib7 1637 34 - - HYPH cord-005453-4057qib7 1637 35 matched match VBN cord-005453-4057qib7 1637 36 sibling sibling NN cord-005453-4057qib7 1637 37 ( ( -LRB- cord-005453-4057qib7 1637 38 n=48 n=48 NN cord-005453-4057qib7 1637 39 ) ) -RRB- cord-005453-4057qib7 1637 40 or or CC cord-005453-4057qib7 1637 41 unrelated unrelated JJ cord-005453-4057qib7 1637 42 ( ( -LRB- cord-005453-4057qib7 1637 43 n=115 n=115 NNP cord-005453-4057qib7 1637 44 ) ) -RRB- cord-005453-4057qib7 1637 45 donors donor NNS cord-005453-4057qib7 1637 46 in in IN cord-005453-4057qib7 1637 47 our -PRON- PRP$ cord-005453-4057qib7 1637 48 center center NN cord-005453-4057qib7 1637 49 between between IN cord-005453-4057qib7 1637 50 1994 1994 CD cord-005453-4057qib7 1637 51 and and CC cord-005453-4057qib7 1637 52 2018 2018 CD cord-005453-4057qib7 1637 53 . . . cord-005453-4057qib7 1638 1 The the DT cord-005453-4057qib7 1638 2 median median JJ cord-005453-4057qib7 1638 3 age age NN cord-005453-4057qib7 1638 4 was be VBD cord-005453-4057qib7 1638 5 56 56 CD cord-005453-4057qib7 1638 6 years year NNS cord-005453-4057qib7 1638 7 ( ( -LRB- cord-005453-4057qib7 1638 8 range range NN cord-005453-4057qib7 1638 9 , , , cord-005453-4057qib7 1638 10 22 22 CD cord-005453-4057qib7 1638 11 to to TO cord-005453-4057qib7 1638 12 75 75 CD cord-005453-4057qib7 1638 13 years year NNS cord-005453-4057qib7 1638 14 ) ) -RRB- cord-005453-4057qib7 1638 15 . . . cord-005453-4057qib7 1639 1 A a DT cord-005453-4057qib7 1639 2 myeloablative myeloablative JJ cord-005453-4057qib7 1639 3 conditioning conditioning NN cord-005453-4057qib7 1639 4 regimen regimen NN cord-005453-4057qib7 1639 5 was be VBD cord-005453-4057qib7 1639 6 performed perform VBN cord-005453-4057qib7 1639 7 in in IN cord-005453-4057qib7 1639 8 142 142 CD cord-005453-4057qib7 1639 9 pts pt NNS cord-005453-4057qib7 1639 10 , , , cord-005453-4057qib7 1639 11 while while IN cord-005453-4057qib7 1639 12 21 21 CD cord-005453-4057qib7 1639 13 pts pt NNS cord-005453-4057qib7 1639 14 where where WRB cord-005453-4057qib7 1639 15 treated treat VBN cord-005453-4057qib7 1639 16 with with IN cord-005453-4057qib7 1639 17 a a DT cord-005453-4057qib7 1639 18 reduced reduce VBN cord-005453-4057qib7 1639 19 intensity intensity NN cord-005453-4057qib7 1639 20 conditioning conditioning NN cord-005453-4057qib7 1639 21 . . . cord-005453-4057qib7 1640 1 Peripheral peripheral JJ cord-005453-4057qib7 1640 2 blood blood NN cord-005453-4057qib7 1640 3 stem stem NN cord-005453-4057qib7 1640 4 cells cell NNS cord-005453-4057qib7 1640 5 ( ( -LRB- cord-005453-4057qib7 1640 6 n=154 n=154 NNP cord-005453-4057qib7 1640 7 ) ) -RRB- cord-005453-4057qib7 1640 8 or or CC cord-005453-4057qib7 1640 9 bone bone NN cord-005453-4057qib7 1640 10 marrow marrow NN cord-005453-4057qib7 1640 11 ( ( -LRB- cord-005453-4057qib7 1640 12 n=9 n=9 NN cord-005453-4057qib7 1640 13 ) ) -RRB- cord-005453-4057qib7 1640 14 with with IN cord-005453-4057qib7 1640 15 a a DT cord-005453-4057qib7 1640 16 median median NN cord-005453-4057qib7 1640 17 of of IN cord-005453-4057qib7 1640 18 7.0 7.0 CD cord-005453-4057qib7 1640 19 x x SYM cord-005453-4057qib7 1640 20 10 10 CD cord-005453-4057qib7 1640 21 6 6 CD cord-005453-4057qib7 1640 22 CD34 CD34 NNP cord-005453-4057qib7 1640 23 + + CC cord-005453-4057qib7 1640 24 cells/ cells/ CD cord-005453-4057qib7 1641 1 kg kg NNP cord-005453-4057qib7 1641 2 bodyweight bodyweight NN cord-005453-4057qib7 1641 3 ( ( -LRB- cord-005453-4057qib7 1641 4 BW BW NNP cord-005453-4057qib7 1641 5 ) ) -RRB- cord-005453-4057qib7 1642 1 ( ( -LRB- cord-005453-4057qib7 1642 2 range range NN cord-005453-4057qib7 1642 3 , , , cord-005453-4057qib7 1642 4 1.0 1.0 CD cord-005453-4057qib7 1642 5 to to TO cord-005453-4057qib7 1642 6 30 30 CD cord-005453-4057qib7 1642 7 ) ) -RRB- cord-005453-4057qib7 1642 8 were be VBD cord-005453-4057qib7 1642 9 transplanted transplant VBN cord-005453-4057qib7 1642 10 . . . cord-005453-4057qib7 1643 1 Splenectomy Splenectomy NNP cord-005453-4057qib7 1643 2 was be VBD cord-005453-4057qib7 1643 3 performed perform VBN cord-005453-4057qib7 1643 4 in in IN cord-005453-4057qib7 1643 5 41 41 CD cord-005453-4057qib7 1643 6 of of IN cord-005453-4057qib7 1643 7 163 163 CD cord-005453-4057qib7 1643 8 pts pt NNS cord-005453-4057qib7 1643 9 : : : cord-005453-4057qib7 1643 10 21 21 CD cord-005453-4057qib7 1643 11 pts pt NNS cord-005453-4057qib7 1643 12 were be VBD cord-005453-4057qib7 1643 13 splenectomized splenectomize VBN cord-005453-4057qib7 1643 14 prior prior RB cord-005453-4057qib7 1643 15 to to IN cord-005453-4057qib7 1643 16 and and CC cord-005453-4057qib7 1643 17 20 20 CD cord-005453-4057qib7 1643 18 pts pt NNS cord-005453-4057qib7 1643 19 after after IN cord-005453-4057qib7 1643 20 allo allo NN cord-005453-4057qib7 1643 21 - - HYPH cord-005453-4057qib7 1643 22 HSCT HSCT NNP cord-005453-4057qib7 1643 23 . . . cord-005453-4057qib7 1644 1 Relapse relapse NN cord-005453-4057qib7 1644 2 was be VBD cord-005453-4057qib7 1644 3 diagnosed diagnose VBN cord-005453-4057qib7 1644 4 in in IN cord-005453-4057qib7 1644 5 22 22 CD cord-005453-4057qib7 1644 6 ( ( -LRB- cord-005453-4057qib7 1644 7 14 14 CD cord-005453-4057qib7 1644 8 % % NN cord-005453-4057qib7 1644 9 ) ) -RRB- cord-005453-4057qib7 1644 10 of of IN cord-005453-4057qib7 1644 11 163 163 CD cord-005453-4057qib7 1644 12 pts pt NNS cord-005453-4057qib7 1644 13 . . . cord-005453-4057qib7 1645 1 The the DT cord-005453-4057qib7 1645 2 median median JJ cord-005453-4057qib7 1645 3 duration duration NN cord-005453-4057qib7 1645 4 to to TO cord-005453-4057qib7 1645 5 relapse relapse NN cord-005453-4057qib7 1645 6 after after IN cord-005453-4057qib7 1645 7 transplantion transplantion NN cord-005453-4057qib7 1645 8 was be VBD cord-005453-4057qib7 1645 9 13 13 CD cord-005453-4057qib7 1645 10 months month NNS cord-005453-4057qib7 1645 11 ( ( -LRB- cord-005453-4057qib7 1645 12 range range NN cord-005453-4057qib7 1645 13 , , , cord-005453-4057qib7 1645 14 3 3 CD cord-005453-4057qib7 1645 15 - - SYM cord-005453-4057qib7 1645 16 99 99 CD cord-005453-4057qib7 1645 17 months month NNS cord-005453-4057qib7 1645 18 ) ) -RRB- cord-005453-4057qib7 1645 19 . . . cord-005453-4057qib7 1646 1 Results result NNS cord-005453-4057qib7 1646 2 : : : cord-005453-4057qib7 1647 1 The the DT cord-005453-4057qib7 1647 2 median median JJ cord-005453-4057qib7 1647 3 duration duration NN cord-005453-4057qib7 1647 4 of of IN cord-005453-4057qib7 1647 5 follow follow NN cord-005453-4057qib7 1647 6 - - HYPH cord-005453-4057qib7 1647 7 up up NN cord-005453-4057qib7 1647 8 of of IN cord-005453-4057qib7 1647 9 this this DT cord-005453-4057qib7 1647 10 cohort cohort NN cord-005453-4057qib7 1647 11 was be VBD cord-005453-4057qib7 1647 12 28 28 CD cord-005453-4057qib7 1647 13 months month NNS cord-005453-4057qib7 1647 14 ( ( -LRB- cord-005453-4057qib7 1647 15 range range NN cord-005453-4057qib7 1647 16 , , , cord-005453-4057qib7 1647 17 2 2 CD cord-005453-4057qib7 1647 18 - - SYM cord-005453-4057qib7 1647 19 120 120 CD cord-005453-4057qib7 1647 20 months month NNS cord-005453-4057qib7 1647 21 ) ) -RRB- cord-005453-4057qib7 1647 22 , , , cord-005453-4057qib7 1647 23 the the DT cord-005453-4057qib7 1647 24 10-year 10-year CD cord-005453-4057qib7 1647 25 overall overall JJ cord-005453-4057qib7 1647 26 survival survival NN cord-005453-4057qib7 1647 27 ( ( -LRB- cord-005453-4057qib7 1647 28 OS OS NNP cord-005453-4057qib7 1647 29 ) ) -RRB- cord-005453-4057qib7 1647 30 was be VBD cord-005453-4057qib7 1647 31 46 46 CD cord-005453-4057qib7 1647 32 % % NN cord-005453-4057qib7 1647 33 . . . cord-005453-4057qib7 1648 1 74 74 CD cord-005453-4057qib7 1648 2 pts pt NNS cord-005453-4057qib7 1648 3 died die VBD cord-005453-4057qib7 1648 4 , , , cord-005453-4057qib7 1648 5 including include VBG cord-005453-4057qib7 1648 6 7 7 CD cord-005453-4057qib7 1648 7 pts pt NNS cord-005453-4057qib7 1648 8 who who WP cord-005453-4057qib7 1648 9 relapsed relapse VBD cord-005453-4057qib7 1648 10 and and CC cord-005453-4057qib7 1648 11 67 67 CD cord-005453-4057qib7 1648 12 pts pt NNS cord-005453-4057qib7 1648 13 who who WP cord-005453-4057qib7 1648 14 died die VBD cord-005453-4057qib7 1648 15 of of IN cord-005453-4057qib7 1648 16 treatment treatment NN cord-005453-4057qib7 1648 17 related relate VBN cord-005453-4057qib7 1648 18 causes cause NNS cord-005453-4057qib7 1648 19 . . . cord-005453-4057qib7 1649 1 The the DT cord-005453-4057qib7 1649 2 observed observed JJ cord-005453-4057qib7 1649 3 probability probability NN cord-005453-4057qib7 1649 4 of of IN cord-005453-4057qib7 1649 5 relapse relapse NN cord-005453-4057qib7 1649 6 was be VBD cord-005453-4057qib7 1649 7 significantly significantly RB cord-005453-4057qib7 1649 8 higher high JJR cord-005453-4057qib7 1649 9 in in IN cord-005453-4057qib7 1649 10 splenectomized splenectomized JJ cord-005453-4057qib7 1649 11 pts pts NN cord-005453-4057qib7 1649 12 than than IN cord-005453-4057qib7 1649 13 in in IN cord-005453-4057qib7 1649 14 non non JJ cord-005453-4057qib7 1649 15 - - JJ cord-005453-4057qib7 1649 16 splenectomized splenectomized JJ cord-005453-4057qib7 1649 17 pts pts NN cord-005453-4057qib7 1649 18 : : : cord-005453-4057qib7 1649 19 37 37 CD cord-005453-4057qib7 1649 20 % % NN cord-005453-4057qib7 1649 21 versus versus IN cord-005453-4057qib7 1649 22 10 10 CD cord-005453-4057qib7 1649 23 % % NN cord-005453-4057qib7 1649 24 ( ( -LRB- cord-005453-4057qib7 1649 25 relative relative JJ cord-005453-4057qib7 1649 26 risk risk NN cord-005453-4057qib7 1649 27 ( ( -LRB- cord-005453-4057qib7 1649 28 RR RR NNP cord-005453-4057qib7 1649 29 ) ) -RRB- cord-005453-4057qib7 1649 30 3.7 3.7 CD cord-005453-4057qib7 1649 31 , , , cord-005453-4057qib7 1649 32 95 95 CD cord-005453-4057qib7 1649 33 % % NN cord-005453-4057qib7 1649 34 CI CI NNP cord-005453-4057qib7 1649 35 , , , cord-005453-4057qib7 1649 36 1.5 1.5 CD cord-005453-4057qib7 1649 37 - - SYM cord-005453-4057qib7 1649 38 9.4 9.4 CD cord-005453-4057qib7 1649 39 , , , cord-005453-4057qib7 1649 40 p=0.007 p=0.007 NNP cord-005453-4057qib7 1649 41 ) ) -RRB- cord-005453-4057qib7 1649 42 . . . cord-005453-4057qib7 1650 1 At at IN cord-005453-4057qib7 1650 2 10 10 CD cord-005453-4057qib7 1650 3 years year NNS cord-005453-4057qib7 1650 4 , , , cord-005453-4057qib7 1650 5 the the DT cord-005453-4057qib7 1650 6 OS OS NNP cord-005453-4057qib7 1650 7 was be VBD cord-005453-4057qib7 1650 8 50 50 CD cord-005453-4057qib7 1650 9 % % NN cord-005453-4057qib7 1650 10 in in IN cord-005453-4057qib7 1650 11 nonsplenectomised nonsplenectomised JJ cord-005453-4057qib7 1650 12 and and CC cord-005453-4057qib7 1650 13 39 39 CD cord-005453-4057qib7 1650 14 % % NN cord-005453-4057qib7 1650 15 in in IN cord-005453-4057qib7 1650 16 splenectomised splenectomised JJ cord-005453-4057qib7 1650 17 pts pt NNS cord-005453-4057qib7 1650 18 ( ( -LRB- cord-005453-4057qib7 1650 19 p=0.35 p=0.35 NNP cord-005453-4057qib7 1650 20 ) ) -RRB- cord-005453-4057qib7 1650 21 ( ( -LRB- cord-005453-4057qib7 1650 22 Fig.1 Fig.1 NNP cord-005453-4057qib7 1650 23 ) ) -RRB- cord-005453-4057qib7 1650 24 . . . cord-005453-4057qib7 1651 1 The the DT cord-005453-4057qib7 1651 2 relapse relapse NN cord-005453-4057qib7 1651 3 rate rate NN cord-005453-4057qib7 1651 4 in in IN cord-005453-4057qib7 1651 5 splenectomised splenectomised JJ cord-005453-4057qib7 1651 6 pts pts NNP cord-005453-4057qib7 1651 7 was be VBD cord-005453-4057qib7 1651 8 independent independent JJ cord-005453-4057qib7 1651 9 of of IN cord-005453-4057qib7 1651 10 pre-(5 pre-(5 NNP cord-005453-4057qib7 1651 11 of of IN cord-005453-4057qib7 1651 12 21 21 CD cord-005453-4057qib7 1651 13 pts pt NNS cord-005453-4057qib7 1651 14 , , , cord-005453-4057qib7 1651 15 24 24 CD cord-005453-4057qib7 1651 16 % % NN cord-005453-4057qib7 1651 17 ) ) -RRB- cord-005453-4057qib7 1651 18 or or CC cord-005453-4057qib7 1651 19 post post JJ cord-005453-4057qib7 1651 20 - - JJ cord-005453-4057qib7 1651 21 transplant transplant NN cord-005453-4057qib7 1651 22 ( ( -LRB- cord-005453-4057qib7 1651 23 6 6 CD cord-005453-4057qib7 1651 24 of of IN cord-005453-4057qib7 1651 25 20 20 CD cord-005453-4057qib7 1651 26 pts pt NNS cord-005453-4057qib7 1651 27 , , , cord-005453-4057qib7 1651 28 30 30 CD cord-005453-4057qib7 1651 29 % % NN cord-005453-4057qib7 1651 30 ) ) -RRB- cord-005453-4057qib7 1651 31 treatment treatment NN cord-005453-4057qib7 1651 32 ( ( -LRB- cord-005453-4057qib7 1651 33 RR RR NNP cord-005453-4057qib7 1651 34 1.3 1.3 CD cord-005453-4057qib7 1651 35 , , , cord-005453-4057qib7 1651 36 95 95 CD cord-005453-4057qib7 1651 37 % % NN cord-005453-4057qib7 1651 38 CI ci NN cord-005453-4057qib7 1651 39 , , , cord-005453-4057qib7 1651 40 p=0.73 p=0.73 NNP cord-005453-4057qib7 1651 41 ) ) -RRB- cord-005453-4057qib7 1651 42 . . . cord-005453-4057qib7 1652 1 Conclusions conclusion NNS cord-005453-4057qib7 1652 2 : : : cord-005453-4057qib7 1653 1 On on IN cord-005453-4057qib7 1653 2 the the DT cord-005453-4057qib7 1653 3 basis basis NN cord-005453-4057qib7 1653 4 of of IN cord-005453-4057qib7 1653 5 our -PRON- PRP$ cord-005453-4057qib7 1653 6 cohort cohort NN cord-005453-4057qib7 1653 7 , , , cord-005453-4057qib7 1653 8 we -PRON- PRP cord-005453-4057qib7 1653 9 could could MD cord-005453-4057qib7 1653 10 assert assert VB cord-005453-4057qib7 1653 11 that that IN cord-005453-4057qib7 1653 12 pre pre VB cord-005453-4057qib7 1653 13 - - JJ cord-005453-4057qib7 1653 14 and and CC cord-005453-4057qib7 1653 15 post post VB cord-005453-4057qib7 1653 16 - - JJ cord-005453-4057qib7 1653 17 allo allo JJ cord-005453-4057qib7 1653 18 - - HYPH cord-005453-4057qib7 1653 19 HSCT HSCT NNP cord-005453-4057qib7 1653 20 splenectomy splenectomy NN cord-005453-4057qib7 1653 21 was be VBD cord-005453-4057qib7 1653 22 equally equally RB cord-005453-4057qib7 1653 23 and and CC cord-005453-4057qib7 1653 24 significantly significantly RB cord-005453-4057qib7 1653 25 associated associate VBN cord-005453-4057qib7 1653 26 with with IN cord-005453-4057qib7 1653 27 an an DT cord-005453-4057qib7 1653 28 increased increase VBN cord-005453-4057qib7 1653 29 relapse relapse NN cord-005453-4057qib7 1653 30 ratio ratio NN cord-005453-4057qib7 1653 31 in in IN cord-005453-4057qib7 1653 32 patients patient NNS cord-005453-4057qib7 1653 33 with with IN cord-005453-4057qib7 1653 34 MF MF NNP cord-005453-4057qib7 1653 35 , , , cord-005453-4057qib7 1653 36 which which WDT cord-005453-4057qib7 1653 37 also also RB cord-005453-4057qib7 1653 38 tends tend VBZ cord-005453-4057qib7 1653 39 to to TO cord-005453-4057qib7 1653 40 negatively negatively RB cord-005453-4057qib7 1653 41 affect affect VB cord-005453-4057qib7 1653 42 overall overall JJ cord-005453-4057qib7 1653 43 survival survival NN cord-005453-4057qib7 1653 44 . . . cord-005453-4057qib7 1654 1 [ [ -LRB- cord-005453-4057qib7 1654 2 [ [ -LRB- cord-005453-4057qib7 1654 3 P088 P088 NNP cord-005453-4057qib7 1654 4 Image image NN cord-005453-4057qib7 1654 5 ] ] -RRB- cord-005453-4057qib7 1654 6 1 1 CD cord-005453-4057qib7 1654 7 . . . cord-005453-4057qib7 1655 1 Figure figure NN cord-005453-4057qib7 1655 2 1 1 CD cord-005453-4057qib7 1655 3 : : : cord-005453-4057qib7 1656 1 The the DT cord-005453-4057qib7 1656 2 overall overall JJ cord-005453-4057qib7 1656 3 survival survival NN cord-005453-4057qib7 1656 4 after after IN cord-005453-4057qib7 1656 5 allo allo NN cord-005453-4057qib7 1656 6 - - HYPH cord-005453-4057qib7 1656 7 HSCT HSCT NNP cord-005453-4057qib7 1656 8 in in IN cord-005453-4057qib7 1656 9 patients patient NNS cord-005453-4057qib7 1656 10 with with IN cord-005453-4057qib7 1656 11 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 1656 12 . . . cord-005453-4057qib7 1656 13 ] ] -RRB- cord-005453-4057qib7 1657 1 Background background NN cord-005453-4057qib7 1657 2 : : : cord-005453-4057qib7 1658 1 B b NN cord-005453-4057qib7 1658 2 - - HYPH cord-005453-4057qib7 1658 3 cell cell NN cord-005453-4057qib7 1658 4 prolymphocytic prolymphocytic JJ cord-005453-4057qib7 1658 5 leukemia leukemia NN cord-005453-4057qib7 1658 6 ( ( -LRB- cord-005453-4057qib7 1658 7 B B NNP cord-005453-4057qib7 1658 8 - - HYPH cord-005453-4057qib7 1658 9 PLL PLL NNP cord-005453-4057qib7 1658 10 ) ) -RRB- cord-005453-4057qib7 1658 11 is be VBZ cord-005453-4057qib7 1658 12 a a DT cord-005453-4057qib7 1658 13 very very RB cord-005453-4057qib7 1658 14 rare rare JJ cord-005453-4057qib7 1658 15 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 1658 16 disorder disorder NN cord-005453-4057qib7 1658 17 . . . cord-005453-4057qib7 1659 1 Although although IN cord-005453-4057qib7 1659 2 allogeneic allogeneic JJ cord-005453-4057qib7 1659 3 stem stem NN cord-005453-4057qib7 1659 4 cell cell NN cord-005453-4057qib7 1659 5 transplantation transplantation NN cord-005453-4057qib7 1659 6 ( ( -LRB- cord-005453-4057qib7 1659 7 alloSCT alloSCT NNP cord-005453-4057qib7 1659 8 ) ) -RRB- cord-005453-4057qib7 1659 9 could could MD cord-005453-4057qib7 1659 10 be be VB cord-005453-4057qib7 1659 11 a a DT cord-005453-4057qib7 1659 12 curative curative JJ cord-005453-4057qib7 1659 13 option option NN cord-005453-4057qib7 1659 14 , , , cord-005453-4057qib7 1659 15 patients patient NNS cord-005453-4057qib7 1659 16 often often RB cord-005453-4057qib7 1659 17 do do VBP cord-005453-4057qib7 1659 18 not not RB cord-005453-4057qib7 1659 19 qualify qualify VB cord-005453-4057qib7 1659 20 for for IN cord-005453-4057qib7 1659 21 this this DT cord-005453-4057qib7 1659 22 consolidation consolidation NN cord-005453-4057qib7 1659 23 treatment treatment NN cord-005453-4057qib7 1659 24 due due IN cord-005453-4057qib7 1659 25 to to IN cord-005453-4057qib7 1659 26 an an DT cord-005453-4057qib7 1659 27 aggressive aggressive JJ cord-005453-4057qib7 1659 28 course course NN cord-005453-4057qib7 1659 29 of of IN cord-005453-4057qib7 1659 30 disease disease NN cord-005453-4057qib7 1659 31 . . . cord-005453-4057qib7 1660 1 In in IN cord-005453-4057qib7 1660 2 this this DT cord-005453-4057qib7 1660 3 case case NN cord-005453-4057qib7 1660 4 study study NN cord-005453-4057qib7 1660 5 , , , cord-005453-4057qib7 1660 6 we -PRON- PRP cord-005453-4057qib7 1660 7 report report VBP cord-005453-4057qib7 1660 8 on on IN cord-005453-4057qib7 1660 9 three three CD cord-005453-4057qib7 1660 10 patients patient NNS cord-005453-4057qib7 1660 11 who who WP cord-005453-4057qib7 1660 12 failed fail VBD cord-005453-4057qib7 1660 13 ibrutinib ibrutinib NN cord-005453-4057qib7 1660 14 therapy therapy NN cord-005453-4057qib7 1660 15 but but CC cord-005453-4057qib7 1660 16 achieved achieve VBD cord-005453-4057qib7 1660 17 complete complete JJ cord-005453-4057qib7 1660 18 remission remission NN cord-005453-4057qib7 1660 19 and and CC cord-005453-4057qib7 1660 20 even even RB cord-005453-4057qib7 1660 21 MRD MRD NNP cord-005453-4057qib7 1660 22 negativity negativity NN cord-005453-4057qib7 1660 23 after after IN cord-005453-4057qib7 1660 24 treatment treatment NN cord-005453-4057qib7 1660 25 with with IN cord-005453-4057qib7 1660 26 the the DT cord-005453-4057qib7 1660 27 chimeric chimeric JJ cord-005453-4057qib7 1660 28 CD20-antibody CD20-antibody NNP cord-005453-4057qib7 1660 29 Rituximab Rituximab NNP cord-005453-4057qib7 1660 30 , , , cord-005453-4057qib7 1660 31 enabling enable VBG cord-005453-4057qib7 1660 32 them -PRON- PRP cord-005453-4057qib7 1660 33 to to TO cord-005453-4057qib7 1660 34 undergo undergo VB cord-005453-4057qib7 1660 35 alloSCT alloSCT NNP cord-005453-4057qib7 1660 36 . . . cord-005453-4057qib7 1661 1 Methods method NNS cord-005453-4057qib7 1661 2 : : : cord-005453-4057qib7 1661 3 Clinical clinical JJ cord-005453-4057qib7 1661 4 data datum NNS cord-005453-4057qib7 1661 5 and and CC cord-005453-4057qib7 1661 6 follow follow VB cord-005453-4057qib7 1661 7 - - HYPH cord-005453-4057qib7 1661 8 up up RP cord-005453-4057qib7 1661 9 data datum NNS cord-005453-4057qib7 1661 10 were be VBD cord-005453-4057qib7 1661 11 collected collect VBN cord-005453-4057qib7 1661 12 by by IN cord-005453-4057qib7 1661 13 chart chart NN cord-005453-4057qib7 1661 14 review review NN cord-005453-4057qib7 1661 15 . . . cord-005453-4057qib7 1662 1 Results result NNS cord-005453-4057qib7 1662 2 : : : cord-005453-4057qib7 1663 1 All all DT cord-005453-4057qib7 1663 2 three three CD cord-005453-4057qib7 1663 3 patients patient NNS cord-005453-4057qib7 1663 4 ( ( -LRB- cord-005453-4057qib7 1663 5 pt#1 pt#1 NNP cord-005453-4057qib7 1663 6 : : : cord-005453-4057qib7 1663 7 male male NN cord-005453-4057qib7 1663 8 , , , cord-005453-4057qib7 1663 9 42 42 CD cord-005453-4057qib7 1663 10 years year NNS cord-005453-4057qib7 1663 11 ; ; : cord-005453-4057qib7 1663 12 pt#2 pt#2 NNP cord-005453-4057qib7 1663 13 : : : cord-005453-4057qib7 1663 14 female female JJ cord-005453-4057qib7 1663 15 , , , cord-005453-4057qib7 1663 16 66 66 CD cord-005453-4057qib7 1663 17 years year NNS cord-005453-4057qib7 1663 18 ; ; : cord-005453-4057qib7 1663 19 pt#3 pt#3 NN cord-005453-4057qib7 1663 20 : : : cord-005453-4057qib7 1663 21 female female JJ cord-005453-4057qib7 1663 22 , , , cord-005453-4057qib7 1663 23 64 64 CD cord-005453-4057qib7 1663 24 years year NNS cord-005453-4057qib7 1663 25 ) ) -RRB- cord-005453-4057qib7 1663 26 were be VBD cord-005453-4057qib7 1663 27 referred refer VBN cord-005453-4057qib7 1663 28 with with IN cord-005453-4057qib7 1663 29 B B NNP cord-005453-4057qib7 1663 30 - - HYPH cord-005453-4057qib7 1663 31 PLL PLL NNP cord-005453-4057qib7 1663 32 harboring harbor VBG cord-005453-4057qib7 1663 33 highly highly RB cord-005453-4057qib7 1663 34 complex complex JJ cord-005453-4057qib7 1663 35 aberrant aberrant JJ cord-005453-4057qib7 1663 36 karyotypes karyotype NNS cord-005453-4057qib7 1663 37 , , , cord-005453-4057qib7 1663 38 including include VBG cord-005453-4057qib7 1663 39 17p 17p CD cord-005453-4057qib7 1663 40 abnormalities abnormality NNS cord-005453-4057qib7 1663 41 in in IN cord-005453-4057qib7 1663 42 pt#1 pt#1 NNP cord-005453-4057qib7 1663 43 and and CC cord-005453-4057qib7 1663 44 pt#2 pt#2 NNP cord-005453-4057qib7 1663 45 . . . cord-005453-4057qib7 1664 1 A a DT cord-005453-4057qib7 1664 2 TP53 TP53 NNP cord-005453-4057qib7 1664 3 mutation mutation NN cord-005453-4057qib7 1664 4 could could MD cord-005453-4057qib7 1664 5 be be VB cord-005453-4057qib7 1664 6 detected detect VBN cord-005453-4057qib7 1664 7 in in IN cord-005453-4057qib7 1664 8 pt#2 pt#2 NNP cord-005453-4057qib7 1664 9 and and CC cord-005453-4057qib7 1664 10 pt#3 pt#3 NNP cord-005453-4057qib7 1664 11 . . . cord-005453-4057qib7 1665 1 All all DT cord-005453-4057qib7 1665 2 three three CD cord-005453-4057qib7 1665 3 patients patient NNS cord-005453-4057qib7 1665 4 had have VBD cord-005453-4057qib7 1665 5 symptomatic symptomatic JJ cord-005453-4057qib7 1665 6 disease disease NN cord-005453-4057qib7 1665 7 with with IN cord-005453-4057qib7 1665 8 rapidly rapidly RB cord-005453-4057qib7 1665 9 increasing increase VBG cord-005453-4057qib7 1665 10 hyperleukocytosis hyperleukocytosis NN cord-005453-4057qib7 1665 11 and and CC cord-005453-4057qib7 1665 12 massive massive JJ cord-005453-4057qib7 1665 13 splenomegaly splenomegaly NN cord-005453-4057qib7 1665 14 . . . cord-005453-4057qib7 1666 1 Two two CD cord-005453-4057qib7 1666 2 of of IN cord-005453-4057qib7 1666 3 them -PRON- PRP cord-005453-4057qib7 1666 4 were be VBD cord-005453-4057qib7 1666 5 treatment treatment NN cord-005453-4057qib7 1666 6 - - HYPH cord-005453-4057qib7 1666 7 naive naive JJ cord-005453-4057qib7 1666 8 and and CC cord-005453-4057qib7 1666 9 one one CD cord-005453-4057qib7 1666 10 relapsed relapse VBD cord-005453-4057qib7 1666 11 after after IN cord-005453-4057qib7 1666 12 chemoimmunotherapy chemoimmunotherapy NNP cord-005453-4057qib7 1666 13 . . . cord-005453-4057qib7 1667 1 All all DT cord-005453-4057qib7 1667 2 patients patient NNS cord-005453-4057qib7 1667 3 were be VBD cord-005453-4057qib7 1667 4 put put VBN cord-005453-4057qib7 1667 5 on on IN cord-005453-4057qib7 1667 6 ibrutinib ibrutinib NNP cord-005453-4057qib7 1667 7 420 420 CD cord-005453-4057qib7 1667 8 mg mg NNP cord-005453-4057qib7 1667 9 . . . cord-005453-4057qib7 1668 1 Despite despite IN cord-005453-4057qib7 1668 2 initial initial JJ cord-005453-4057qib7 1668 3 response response NN cord-005453-4057qib7 1668 4 to to IN cord-005453-4057qib7 1668 5 treatment treatment NN cord-005453-4057qib7 1668 6 , , , cord-005453-4057qib7 1668 7 two two CD cord-005453-4057qib7 1668 8 patients patient NNS cord-005453-4057qib7 1668 9 developed develop VBD cord-005453-4057qib7 1668 10 progressive progressive JJ cord-005453-4057qib7 1668 11 disease disease NN cord-005453-4057qib7 1668 12 after after IN cord-005453-4057qib7 1668 13 4 4 CD cord-005453-4057qib7 1668 14 ( ( -LRB- cord-005453-4057qib7 1668 15 pt#1 pt#1 NNP cord-005453-4057qib7 1668 16 ) ) -RRB- cord-005453-4057qib7 1668 17 and and CC cord-005453-4057qib7 1668 18 9 9 CD cord-005453-4057qib7 1668 19 months month NNS cord-005453-4057qib7 1668 20 ( ( -LRB- cord-005453-4057qib7 1668 21 pt#2 pt#2 NNP cord-005453-4057qib7 1668 22 ) ) -RRB- cord-005453-4057qib7 1668 23 on on IN cord-005453-4057qib7 1668 24 ibrutinib ibrutinib NN cord-005453-4057qib7 1668 25 , , , cord-005453-4057qib7 1668 26 whereas whereas IN cord-005453-4057qib7 1668 27 pt#3 pt#3 NNP cord-005453-4057qib7 1668 28 remained remain VBD cord-005453-4057qib7 1668 29 in in IN cord-005453-4057qib7 1668 30 partial partial JJ cord-005453-4057qib7 1668 31 remission remission NN cord-005453-4057qib7 1668 32 with with IN cord-005453-4057qib7 1668 33 persisting persist VBG cord-005453-4057qib7 1668 34 leukocytosis leukocytosis NN cord-005453-4057qib7 1668 35 , , , cord-005453-4057qib7 1668 36 precluding preclude VBG cord-005453-4057qib7 1668 37 consolidating consolidate VBG cord-005453-4057qib7 1668 38 alloSCT alloSCT NNP cord-005453-4057qib7 1668 39 as as IN cord-005453-4057qib7 1668 40 originally originally RB cord-005453-4057qib7 1668 41 intended intend VBN cord-005453-4057qib7 1668 42 . . . cord-005453-4057qib7 1669 1 In in IN cord-005453-4057qib7 1669 2 pt#1 pt#1 NNP cord-005453-4057qib7 1669 3 , , , cord-005453-4057qib7 1669 4 ibrutinib ibrutinib NNP cord-005453-4057qib7 1669 5 was be VBD cord-005453-4057qib7 1669 6 replaced replace VBN cord-005453-4057qib7 1669 7 by by IN cord-005453-4057qib7 1669 8 venetoclax venetoclax NNP cord-005453-4057qib7 1669 9 , , , cord-005453-4057qib7 1669 10 but but CC cord-005453-4057qib7 1669 11 without without IN cord-005453-4057qib7 1669 12 response response NN cord-005453-4057qib7 1669 13 . . . cord-005453-4057qib7 1670 1 In in IN cord-005453-4057qib7 1670 2 order order NN cord-005453-4057qib7 1670 3 to to TO cord-005453-4057qib7 1670 4 control control VB cord-005453-4057qib7 1670 5 rapid rapid JJ cord-005453-4057qib7 1670 6 lymphoproliferation lymphoproliferation NN cord-005453-4057qib7 1670 7 , , , cord-005453-4057qib7 1670 8 rituximab rituximab NNP cord-005453-4057qib7 1670 9 was be VBD cord-005453-4057qib7 1670 10 added add VBN cord-005453-4057qib7 1670 11 to to IN cord-005453-4057qib7 1670 12 venetoclax venetoclax NNP cord-005453-4057qib7 1670 13 . . . cord-005453-4057qib7 1671 1 Grade grade NN cord-005453-4057qib7 1671 2 4 4 CD cord-005453-4057qib7 1671 3 infusion infusion NN cord-005453-4057qib7 1671 4 reaction reaction NN cord-005453-4057qib7 1671 5 / / SYM cord-005453-4057qib7 1671 6 tumor tumor NN cord-005453-4057qib7 1671 7 lysis lysis NN cord-005453-4057qib7 1671 8 syndrome syndrome NN cord-005453-4057qib7 1671 9 ( ( -LRB- cord-005453-4057qib7 1671 10 TLS TLS NNP cord-005453-4057qib7 1671 11 ) ) -RRB- cord-005453-4057qib7 1671 12 ( ( -LRB- cord-005453-4057qib7 1671 13 fever fever NN cord-005453-4057qib7 1671 14 , , , cord-005453-4057qib7 1671 15 tachycardia tachycardia NN cord-005453-4057qib7 1671 16 and and CC cord-005453-4057qib7 1671 17 hypotonia hypotonia NNS cord-005453-4057qib7 1671 18 requiring require VBG cord-005453-4057qib7 1671 19 intravenous intravenous JJ cord-005453-4057qib7 1671 20 vasopressors vasopressor NNS cord-005453-4057qib7 1671 21 ) ) -RRB- cord-005453-4057qib7 1671 22 followed follow VBD cord-005453-4057qib7 1671 23 each each DT cord-005453-4057qib7 1671 24 rituximab rituximab JJ cord-005453-4057qib7 1671 25 administration administration NN cord-005453-4057qib7 1671 26 despite despite IN cord-005453-4057qib7 1671 27 fractionating fractionate VBG cord-005453-4057qib7 1671 28 rituximab rituximab NN cord-005453-4057qib7 1671 29 to to IN cord-005453-4057qib7 1671 30 small small JJ cord-005453-4057qib7 1671 31 doses dose NNS cord-005453-4057qib7 1671 32 . . . cord-005453-4057qib7 1672 1 However however RB cord-005453-4057qib7 1672 2 , , , cord-005453-4057qib7 1672 3 continuation continuation NN cord-005453-4057qib7 1672 4 of of IN cord-005453-4057qib7 1672 5 rituximab rituximab NN cord-005453-4057qib7 1672 6 ( ( -LRB- cord-005453-4057qib7 1672 7 100mg 100mg NNP cord-005453-4057qib7 1672 8 / / SYM cord-005453-4057qib7 1672 9 d d XX cord-005453-4057qib7 1672 10 over over IN cord-005453-4057qib7 1672 11 10d 10d NNS cord-005453-4057qib7 1672 12 ) ) -RRB- cord-005453-4057qib7 1672 13 led lead VBD cord-005453-4057qib7 1672 14 to to TO cord-005453-4057qib7 1672 15 complete complete VB cord-005453-4057qib7 1672 16 and and CC cord-005453-4057qib7 1672 17 durable durable JJ cord-005453-4057qib7 1672 18 clearance clearance NN cord-005453-4057qib7 1672 19 of of IN cord-005453-4057qib7 1672 20 hyperleukocytosis hyperleukocytosis NNP cord-005453-4057qib7 1672 21 ( ( -LRB- cord-005453-4057qib7 1672 22 from from IN cord-005453-4057qib7 1672 23 250 250 CD cord-005453-4057qib7 1672 24 / / SYM cord-005453-4057qib7 1672 25 nl nl NN cord-005453-4057qib7 1672 26 to to IN cord-005453-4057qib7 1672 27 MRD MRD NNP cord-005453-4057qib7 1672 28 negativity negativity NN cord-005453-4057qib7 1672 29 ) ) -RRB- cord-005453-4057qib7 1672 30 despite despite IN cord-005453-4057qib7 1672 31 venetoclax venetoclax NNP cord-005453-4057qib7 1672 32 cessation cessation NN cord-005453-4057qib7 1672 33 . . . cord-005453-4057qib7 1673 1 A a DT cord-005453-4057qib7 1673 2 similar similar JJ cord-005453-4057qib7 1673 3 pattern pattern NN cord-005453-4057qib7 1673 4 was be VBD cord-005453-4057qib7 1673 5 observed observe VBN cord-005453-4057qib7 1673 6 in in IN cord-005453-4057qib7 1673 7 pt#2 pt#2 NNP cord-005453-4057qib7 1673 8 , , , cord-005453-4057qib7 1673 9 who who WP cord-005453-4057qib7 1673 10 received receive VBD cord-005453-4057qib7 1673 11 rituximab rituximab JJ cord-005453-4057qib7 1673 12 while while IN cord-005453-4057qib7 1673 13 showing show VBG cord-005453-4057qib7 1673 14 rapidly rapidly RB cord-005453-4057qib7 1673 15 increasing increase VBG cord-005453-4057qib7 1673 16 leukocytosis leukocytosis NN cord-005453-4057qib7 1673 17 upon upon IN cord-005453-4057qib7 1673 18 ibrutinib ibrutinib NNP cord-005453-4057qib7 1673 19 . . . cord-005453-4057qib7 1674 1 Again again RB cord-005453-4057qib7 1674 2 , , , cord-005453-4057qib7 1674 3 complete complete JJ cord-005453-4057qib7 1674 4 clearance clearance NN cord-005453-4057qib7 1674 5 of of IN cord-005453-4057qib7 1674 6 B b NN cord-005453-4057qib7 1674 7 - - HYPH cord-005453-4057qib7 1674 8 PLL PLL NNP cord-005453-4057qib7 1674 9 cells cell NNS cord-005453-4057qib7 1674 10 in in IN cord-005453-4057qib7 1674 11 the the DT cord-005453-4057qib7 1674 12 peripheral peripheral JJ cord-005453-4057qib7 1674 13 blood blood NN cord-005453-4057qib7 1674 14 ( ( -LRB- cord-005453-4057qib7 1674 15 from from IN cord-005453-4057qib7 1674 16 148 148 CD cord-005453-4057qib7 1674 17 / / SYM cord-005453-4057qib7 1674 18 nl nl NN cord-005453-4057qib7 1674 19 to to IN cord-005453-4057qib7 1674 20 MRD MRD NNP cord-005453-4057qib7 1674 21 negativity negativity NN cord-005453-4057qib7 1674 22 ) ) -RRB- cord-005453-4057qib7 1674 23 occurred occur VBD cord-005453-4057qib7 1674 24 after after IN cord-005453-4057qib7 1674 25 initial initial JJ cord-005453-4057qib7 1674 26 grade grade NN cord-005453-4057qib7 1674 27 4 4 CD cord-005453-4057qib7 1674 28 TLS TLS NNP cord-005453-4057qib7 1674 29 despite despite IN cord-005453-4057qib7 1674 30 only only RB cord-005453-4057qib7 1674 31 modest modest JJ cord-005453-4057qib7 1674 32 CD20 CD20 NNP cord-005453-4057qib7 1674 33 expression expression NN cord-005453-4057qib7 1674 34 on on IN cord-005453-4057qib7 1674 35 tumor tumor NN cord-005453-4057qib7 1674 36 cells cell NNS cord-005453-4057qib7 1674 37 in in IN cord-005453-4057qib7 1674 38 this this DT cord-005453-4057qib7 1674 39 patient patient NN cord-005453-4057qib7 1674 40 . . . cord-005453-4057qib7 1675 1 Also also RB cord-005453-4057qib7 1675 2 , , , cord-005453-4057qib7 1675 3 pt#3 pt#3 NNP cord-005453-4057qib7 1675 4 achieved achieve VBD cord-005453-4057qib7 1675 5 profound profound JJ cord-005453-4057qib7 1675 6 B b NN cord-005453-4057qib7 1675 7 - - HYPH cord-005453-4057qib7 1675 8 PLL pll JJ cord-005453-4057qib7 1675 9 cell cell NN cord-005453-4057qib7 1675 10 depletion depletion NN cord-005453-4057qib7 1675 11 ( ( -LRB- cord-005453-4057qib7 1675 12 from from IN cord-005453-4057qib7 1675 13 38 38 CD cord-005453-4057qib7 1675 14 / / SYM cord-005453-4057qib7 1675 15 nl nl NN cord-005453-4057qib7 1675 16 to to IN cord-005453-4057qib7 1675 17 a a DT cord-005453-4057qib7 1675 18 MRD MRD NNP cord-005453-4057qib7 1675 19 rate rate NN cord-005453-4057qib7 1675 20 of of IN cord-005453-4057qib7 1675 21 1.1 1.1 CD cord-005453-4057qib7 1675 22 % % NN cord-005453-4057qib7 1675 23 ) ) -RRB- cord-005453-4057qib7 1675 24 upon upon IN cord-005453-4057qib7 1675 25 addition addition NN cord-005453-4057qib7 1675 26 of of IN cord-005453-4057qib7 1675 27 rituximab rituximab NN cord-005453-4057qib7 1675 28 to to IN cord-005453-4057qib7 1675 29 ibrutinib ibrutinib NNP cord-005453-4057qib7 1675 30 ( ( -LRB- cord-005453-4057qib7 1675 31 without without IN cord-005453-4057qib7 1675 32 TLS TLS NNP cord-005453-4057qib7 1675 33 in in IN cord-005453-4057qib7 1675 34 this this DT cord-005453-4057qib7 1675 35 case case NN cord-005453-4057qib7 1675 36 ) ) -RRB- cord-005453-4057qib7 1675 37 . . . cord-005453-4057qib7 1676 1 Subsequently subsequently RB cord-005453-4057qib7 1676 2 , , , cord-005453-4057qib7 1676 3 all all DT cord-005453-4057qib7 1676 4 three three CD cord-005453-4057qib7 1676 5 patients patient NNS cord-005453-4057qib7 1676 6 were be VBD cord-005453-4057qib7 1676 7 able able JJ cord-005453-4057qib7 1676 8 to to TO cord-005453-4057qib7 1676 9 undergo undergo VB cord-005453-4057qib7 1676 10 alloSCT alloSCT NNP cord-005453-4057qib7 1676 11 after after IN cord-005453-4057qib7 1676 12 conditioning conditioning NN cord-005453-4057qib7 1676 13 with with IN cord-005453-4057qib7 1676 14 fludarabine fludarabine NN cord-005453-4057qib7 1676 15 and and CC cord-005453-4057qib7 1676 16 total total JJ cord-005453-4057qib7 1676 17 body body NN cord-005453-4057qib7 1676 18 irradiation irradiation NN cord-005453-4057qib7 1676 19 with with IN cord-005453-4057qib7 1676 20 8 8 CD cord-005453-4057qib7 1676 21 Gy Gy NNP cord-005453-4057qib7 1676 22 . . . cord-005453-4057qib7 1677 1 Pt#1 Pt#1 NNP cord-005453-4057qib7 1677 2 received receive VBD cord-005453-4057qib7 1677 3 stem stem NN cord-005453-4057qib7 1677 4 cells cell NNS cord-005453-4057qib7 1677 5 from from IN cord-005453-4057qib7 1677 6 a a DT cord-005453-4057qib7 1677 7 HLA HLA NNP cord-005453-4057qib7 1677 8 - - HYPH cord-005453-4057qib7 1677 9 ident ident NN cord-005453-4057qib7 1677 10 sibling sibling NN cord-005453-4057qib7 1677 11 donor donor NN cord-005453-4057qib7 1677 12 , , , cord-005453-4057qib7 1677 13 whereas whereas IN cord-005453-4057qib7 1677 14 Pt#2 Pt#2 NNS cord-005453-4057qib7 1677 15 and and CC cord-005453-4057qib7 1677 16 Pt#3 pt#3 PRP cord-005453-4057qib7 1677 17 had have VBD cord-005453-4057qib7 1677 18 unrelated unrelated JJ cord-005453-4057qib7 1677 19 donors donor NNS cord-005453-4057qib7 1677 20 ( ( -LRB- cord-005453-4057qib7 1677 21 HLA HLA NNP cord-005453-4057qib7 1677 22 - - HYPH cord-005453-4057qib7 1677 23 ident ident NNP cord-005453-4057qib7 1677 24 and and CC cord-005453-4057qib7 1677 25 HLA HLA NNP cord-005453-4057qib7 1677 26 - - HYPH cord-005453-4057qib7 1677 27 matched match VBN cord-005453-4057qib7 1677 28 respectively respectively RB cord-005453-4057qib7 1677 29 ) ) -RRB- cord-005453-4057qib7 1677 30 . . . cord-005453-4057qib7 1678 1 With with IN cord-005453-4057qib7 1678 2 follow follow NN cord-005453-4057qib7 1678 3 - - HYPH cord-005453-4057qib7 1678 4 up up NN cord-005453-4057qib7 1678 5 times time NNS cord-005453-4057qib7 1678 6 of of IN cord-005453-4057qib7 1678 7 17 17 CD cord-005453-4057qib7 1678 8 and and CC cord-005453-4057qib7 1678 9 11 11 CD cord-005453-4057qib7 1678 10 months month NNS cord-005453-4057qib7 1678 11 post post JJ cord-005453-4057qib7 1678 12 - - NN cord-005453-4057qib7 1678 13 transplant transplant NN cord-005453-4057qib7 1678 14 , , , cord-005453-4057qib7 1678 15 pt#1 pt#1 NNP cord-005453-4057qib7 1678 16 and and CC cord-005453-4057qib7 1678 17 pt#2 pt#2 NNP cord-005453-4057qib7 1678 18 are be VBP cord-005453-4057qib7 1678 19 currently currently RB cord-005453-4057qib7 1678 20 in in IN cord-005453-4057qib7 1678 21 ongoing ongoing JJ cord-005453-4057qib7 1678 22 MRD MRD NNP cord-005453-4057qib7 1678 23 - - HYPH cord-005453-4057qib7 1678 24 negative negative JJ cord-005453-4057qib7 1678 25 remission remission NN cord-005453-4057qib7 1678 26 . . . cord-005453-4057qib7 1679 1 Pt#1 Pt#1 NNP cord-005453-4057qib7 1679 2 developed develop VBD cord-005453-4057qib7 1679 3 an an DT cord-005453-4057qib7 1679 4 acute acute JJ cord-005453-4057qib7 1679 5 graft graft NN cord-005453-4057qib7 1679 6 - - HYPH cord-005453-4057qib7 1679 7 versus versus IN cord-005453-4057qib7 1679 8 - - HYPH cord-005453-4057qib7 1679 9 host host NN cord-005453-4057qib7 1679 10 disease disease NN cord-005453-4057qib7 1679 11 ( ( -LRB- cord-005453-4057qib7 1679 12 GvHD GvHD NNP cord-005453-4057qib7 1679 13 ) ) -RRB- cord-005453-4057qib7 1679 14 of of IN cord-005453-4057qib7 1679 15 the the DT cord-005453-4057qib7 1679 16 liver liver NN cord-005453-4057qib7 1679 17 ( ( -LRB- cord-005453-4057qib7 1679 18 grade grade NN cord-005453-4057qib7 1679 19 3 3 CD cord-005453-4057qib7 1679 20 ) ) -RRB- cord-005453-4057qib7 1679 21 , , , cord-005453-4057qib7 1679 22 nevertheless nevertheless RB cord-005453-4057qib7 1679 23 the the DT cord-005453-4057qib7 1679 24 clinical clinical JJ cord-005453-4057qib7 1679 25 course course NN cord-005453-4057qib7 1679 26 was be VBD cord-005453-4057qib7 1679 27 well well RB cord-005453-4057qib7 1679 28 controlled control VBN cord-005453-4057qib7 1679 29 by by IN cord-005453-4057qib7 1679 30 immunosuppression immunosuppression NN cord-005453-4057qib7 1679 31 . . . cord-005453-4057qib7 1680 1 In in IN cord-005453-4057qib7 1680 2 pt#2 pt#2 NNP cord-005453-4057qib7 1680 3 a a DT cord-005453-4057qib7 1680 4 chronic chronic JJ cord-005453-4057qib7 1680 5 GvHD gvhd NN cord-005453-4057qib7 1680 6 of of IN cord-005453-4057qib7 1680 7 the the DT cord-005453-4057qib7 1680 8 skin skin NN cord-005453-4057qib7 1680 9 occurred occur VBD cord-005453-4057qib7 1680 10 . . . cord-005453-4057qib7 1681 1 Pt#3 Pt#3 '' cord-005453-4057qib7 1682 1 , , , cord-005453-4057qib7 1682 2 who who WP cord-005453-4057qib7 1682 3 achieved achieve VBD cord-005453-4057qib7 1682 4 MRD MRD NNP cord-005453-4057qib7 1682 5 negativity negativity NN cord-005453-4057qib7 1682 6 after after IN cord-005453-4057qib7 1682 7 alloSCT alloSCT NNP cord-005453-4057qib7 1682 8 , , , cord-005453-4057qib7 1682 9 developed develop VBD cord-005453-4057qib7 1682 10 acute acute JJ cord-005453-4057qib7 1682 11 and and CC cord-005453-4057qib7 1682 12 chronic chronic JJ cord-005453-4057qib7 1682 13 steroidrefractory steroidrefractory NNP cord-005453-4057qib7 1682 14 GvHD GvHD NNP cord-005453-4057qib7 1682 15 of of IN cord-005453-4057qib7 1682 16 the the DT cord-005453-4057qib7 1682 17 skin skin NN cord-005453-4057qib7 1682 18 and and CC cord-005453-4057qib7 1682 19 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 1682 20 tract tract NN cord-005453-4057qib7 1682 21 . . . cord-005453-4057qib7 1683 1 Nine nine CD cord-005453-4057qib7 1683 2 months month NNS cord-005453-4057qib7 1683 3 post post NN cord-005453-4057qib7 1683 4 - - NN cord-005453-4057qib7 1683 5 transplant transplant NN cord-005453-4057qib7 1683 6 , , , cord-005453-4057qib7 1683 7 GvHD GvHD NNP cord-005453-4057qib7 1683 8 deteriorated deteriorate VBD cord-005453-4057qib7 1683 9 and and CC cord-005453-4057qib7 1683 10 after after IN cord-005453-4057qib7 1683 11 further further JJ cord-005453-4057qib7 1683 12 complications complication NNS cord-005453-4057qib7 1683 13 the the DT cord-005453-4057qib7 1683 14 patient patient NN cord-005453-4057qib7 1683 15 died die VBD cord-005453-4057qib7 1683 16 of of IN cord-005453-4057qib7 1683 17 pneumonia pneumonia NN cord-005453-4057qib7 1683 18 11 11 CD cord-005453-4057qib7 1683 19 months month NNS cord-005453-4057qib7 1683 20 post post JJ cord-005453-4057qib7 1683 21 - - NN cord-005453-4057qib7 1683 22 transplant transplant NN cord-005453-4057qib7 1683 23 . . . cord-005453-4057qib7 1684 1 Conclusions conclusion NNS cord-005453-4057qib7 1684 2 : : : cord-005453-4057qib7 1685 1 Supplementary supplementary JJ cord-005453-4057qib7 1685 2 treatment treatment NN cord-005453-4057qib7 1685 3 with with IN cord-005453-4057qib7 1685 4 rituximab rituximab NN cord-005453-4057qib7 1685 5 can can MD cord-005453-4057qib7 1685 6 induce induce VB cord-005453-4057qib7 1685 7 deep deep JJ cord-005453-4057qib7 1685 8 remissions remission NNS cord-005453-4057qib7 1685 9 in in IN cord-005453-4057qib7 1685 10 patients patient NNS cord-005453-4057qib7 1685 11 with with IN cord-005453-4057qib7 1685 12 ibrutinibresistant ibrutinibresistant NNP cord-005453-4057qib7 1685 13 , , , cord-005453-4057qib7 1685 14 genetically genetically RB cord-005453-4057qib7 1685 15 poor poor JJ cord-005453-4057qib7 1685 16 - - HYPH cord-005453-4057qib7 1685 17 risk risk NN cord-005453-4057qib7 1685 18 B B NNP cord-005453-4057qib7 1685 19 - - HYPH cord-005453-4057qib7 1685 20 PLL PLL NNP cord-005453-4057qib7 1685 21 , , , cord-005453-4057qib7 1685 22 thereby thereby RB cord-005453-4057qib7 1685 23 enabling enable VBG cord-005453-4057qib7 1685 24 them -PRON- PRP cord-005453-4057qib7 1685 25 to to TO cord-005453-4057qib7 1685 26 undergo undergo VB cord-005453-4057qib7 1685 27 successful successful JJ cord-005453-4057qib7 1685 28 consolidation consolidation NN cord-005453-4057qib7 1685 29 with with IN cord-005453-4057qib7 1685 30 alloSCT alloSCT NNP cord-005453-4057qib7 1685 31 . . . cord-005453-4057qib7 1686 1 A a DT cord-005453-4057qib7 1686 2 high high JJ cord-005453-4057qib7 1686 3 risk risk NN cord-005453-4057qib7 1686 4 of of IN cord-005453-4057qib7 1686 5 life life NN cord-005453-4057qib7 1686 6 - - HYPH cord-005453-4057qib7 1686 7 threatening threaten VBG cord-005453-4057qib7 1686 8 infusion infusion NN cord-005453-4057qib7 1686 9 reactions reaction NNS cord-005453-4057qib7 1686 10 / / SYM cord-005453-4057qib7 1686 11 TLS TLS NNP cord-005453-4057qib7 1686 12 associated associate VBN cord-005453-4057qib7 1686 13 with with IN cord-005453-4057qib7 1686 14 the the DT cord-005453-4057qib7 1686 15 addition addition NN cord-005453-4057qib7 1686 16 of of IN cord-005453-4057qib7 1686 17 rituximab rituximab NN cord-005453-4057qib7 1686 18 has have VBZ cord-005453-4057qib7 1686 19 to to TO cord-005453-4057qib7 1686 20 be be VB cord-005453-4057qib7 1686 21 taken take VBN cord-005453-4057qib7 1686 22 into into IN cord-005453-4057qib7 1686 23 account account NN cord-005453-4057qib7 1686 24 . . . cord-005453-4057qib7 1687 1 Background background NN cord-005453-4057qib7 1687 2 : : : cord-005453-4057qib7 1688 1 There there EX cord-005453-4057qib7 1688 2 is be VBZ cord-005453-4057qib7 1688 3 little little JJ cord-005453-4057qib7 1688 4 experience experience NN cord-005453-4057qib7 1688 5 on on IN cord-005453-4057qib7 1688 6 the the DT cord-005453-4057qib7 1688 7 use use NN cord-005453-4057qib7 1688 8 of of IN cord-005453-4057qib7 1688 9 the the DT cord-005453-4057qib7 1688 10 newer new JJR cord-005453-4057qib7 1688 11 targeted target VBN cord-005453-4057qib7 1688 12 therapies therapy NNS cord-005453-4057qib7 1688 13 in in IN cord-005453-4057qib7 1688 14 CLL CLL NNP cord-005453-4057qib7 1688 15 patients patient NNS cord-005453-4057qib7 1688 16 relapsed relapse VBD cord-005453-4057qib7 1688 17 after after IN cord-005453-4057qib7 1688 18 allogeneic allogeneic NN cord-005453-4057qib7 1688 19 stem stem NN cord-005453-4057qib7 1688 20 cell cell NN cord-005453-4057qib7 1688 21 transplantation transplantation NN cord-005453-4057qib7 1688 22 ( ( -LRB- cord-005453-4057qib7 1688 23 allo allo FW cord-005453-4057qib7 1688 24 - - HYPH cord-005453-4057qib7 1688 25 SCT SCT NNP cord-005453-4057qib7 1688 26 ) ) -RRB- cord-005453-4057qib7 1688 27 . . . cord-005453-4057qib7 1689 1 Against against IN cord-005453-4057qib7 1689 2 this this DT cord-005453-4057qib7 1689 3 background background NN cord-005453-4057qib7 1689 4 , , , cord-005453-4057qib7 1689 5 we -PRON- PRP cord-005453-4057qib7 1689 6 evaluate evaluate VBP cord-005453-4057qib7 1689 7 the the DT cord-005453-4057qib7 1689 8 safety safety NN cord-005453-4057qib7 1689 9 and and CC cord-005453-4057qib7 1689 10 efficacy efficacy NN cord-005453-4057qib7 1689 11 of of IN cord-005453-4057qib7 1689 12 the the DT cord-005453-4057qib7 1689 13 BCR BCR NNP cord-005453-4057qib7 1689 14 inhibitors inhibitor NNS cord-005453-4057qib7 1689 15 ( ( -LRB- cord-005453-4057qib7 1689 16 BCRi BCRi NNP cord-005453-4057qib7 1689 17 ) ) -RRB- cord-005453-4057qib7 1689 18 , , , cord-005453-4057qib7 1689 19 ibrutinib ibrutinib NNP cord-005453-4057qib7 1689 20 and and CC cord-005453-4057qib7 1689 21 idelalisib idelalisib NNP cord-005453-4057qib7 1689 22 , , , cord-005453-4057qib7 1689 23 administered administer VBN cord-005453-4057qib7 1689 24 after after IN cord-005453-4057qib7 1689 25 allo allo NN cord-005453-4057qib7 1689 26 - - HYPH cord-005453-4057qib7 1689 27 SCT SCT NNP cord-005453-4057qib7 1689 28 for for IN cord-005453-4057qib7 1689 29 the the DT cord-005453-4057qib7 1689 30 purpose purpose NN cord-005453-4057qib7 1689 31 of of IN cord-005453-4057qib7 1689 32 treating treat VBG cord-005453-4057qib7 1689 33 the the DT cord-005453-4057qib7 1689 34 CLL CLL NNP cord-005453-4057qib7 1689 35 relapse relapse NN cord-005453-4057qib7 1689 36 . . . cord-005453-4057qib7 1690 1 Methods method NNS cord-005453-4057qib7 1690 2 : : : cord-005453-4057qib7 1691 1 Data datum NNS cord-005453-4057qib7 1691 2 from from IN cord-005453-4057qib7 1691 3 11 11 CD cord-005453-4057qib7 1691 4 CLL CLL NNP cord-005453-4057qib7 1691 5 pts pts NNP cord-005453-4057qib7 1691 6 who who WP cord-005453-4057qib7 1691 7 relapsed relapse VBD cord-005453-4057qib7 1691 8 after after IN cord-005453-4057qib7 1691 9 SCT SCT NNP cord-005453-4057qib7 1691 10 , , , cord-005453-4057qib7 1691 11 and and CC cord-005453-4057qib7 1691 12 were be VBD cord-005453-4057qib7 1691 13 subsequently subsequently RB cord-005453-4057qib7 1691 14 treated treat VBN cord-005453-4057qib7 1691 15 with with IN cord-005453-4057qib7 1691 16 ibrutinib ibrutinib NNP cord-005453-4057qib7 1691 17 ( ( -LRB- cord-005453-4057qib7 1691 18 n=6 n=6 NNP cord-005453-4057qib7 1691 19 ) ) -RRB- cord-005453-4057qib7 1691 20 , , , cord-005453-4057qib7 1691 21 idelalisib idelalisib NNP cord-005453-4057qib7 1691 22 ( ( -LRB- cord-005453-4057qib7 1691 23 n=3 n=3 NN cord-005453-4057qib7 1691 24 ) ) -RRB- cord-005453-4057qib7 1691 25 or or CC cord-005453-4057qib7 1691 26 both both DT cord-005453-4057qib7 1691 27 ( ( -LRB- cord-005453-4057qib7 1691 28 n=2),were n=2),were RB cord-005453-4057qib7 1691 29 retrospectively retrospectively RB cord-005453-4057qib7 1691 30 collected collect VBN cord-005453-4057qib7 1691 31 in in IN cord-005453-4057qib7 1691 32 collaboration collaboration NN cord-005453-4057qib7 1691 33 with with IN cord-005453-4057qib7 1691 34 the the DT cord-005453-4057qib7 1691 35 Spanish spanish JJ cord-005453-4057qib7 1691 36 group group NN cord-005453-4057qib7 1691 37 of of IN cord-005453-4057qib7 1691 38 CLL CLL NNP cord-005453-4057qib7 1691 39 ( ( -LRB- cord-005453-4057qib7 1691 40 GELLC GELLC NNP cord-005453-4057qib7 1691 41 ) ) -RRB- cord-005453-4057qib7 1691 42 and and CC cord-005453-4057qib7 1691 43 the the DT cord-005453-4057qib7 1691 44 Spanish spanish JJ cord-005453-4057qib7 1691 45 group group NN cord-005453-4057qib7 1691 46 of of IN cord-005453-4057qib7 1691 47 Stem Stem NNP cord-005453-4057qib7 1691 48 Cell Cell NNP cord-005453-4057qib7 1691 49 Transplantation transplantation NN cord-005453-4057qib7 1691 50 ( ( -LRB- cord-005453-4057qib7 1691 51 GETH GETH NNP cord-005453-4057qib7 1691 52 ) ) -RRB- cord-005453-4057qib7 1691 53 . . . cord-005453-4057qib7 1692 1 Results result NNS cord-005453-4057qib7 1692 2 : : : cord-005453-4057qib7 1693 1 Transplant transplant NN cord-005453-4057qib7 1693 2 characteristics characteristic NNS cord-005453-4057qib7 1693 3 are be VBP cord-005453-4057qib7 1693 4 summarized summarize VBN cord-005453-4057qib7 1693 5 in in IN cord-005453-4057qib7 1693 6 table table NN cord-005453-4057qib7 1693 7 1 1 CD cord-005453-4057qib7 1693 8 . . . cord-005453-4057qib7 1694 1 Eight eight CD cord-005453-4057qib7 1694 2 patients patient NNS cord-005453-4057qib7 1694 3 received receive VBD cord-005453-4057qib7 1694 4 the the DT cord-005453-4057qib7 1694 5 BCRi BCRi NNS cord-005453-4057qib7 1694 6 as as IN cord-005453-4057qib7 1694 7 the the DT cord-005453-4057qib7 1694 8 first first JJ cord-005453-4057qib7 1694 9 salvage salvage NN cord-005453-4057qib7 1694 10 treatment treatment NN cord-005453-4057qib7 1694 11 after after IN cord-005453-4057qib7 1694 12 SCT SCT NNP cord-005453-4057qib7 1694 13 relapse relapse NN cord-005453-4057qib7 1694 14 , , , cord-005453-4057qib7 1694 15 whereas whereas IN cord-005453-4057qib7 1694 16 3 3 CD cord-005453-4057qib7 1694 17 patients patient NNS cord-005453-4057qib7 1694 18 had have VBD cord-005453-4057qib7 1694 19 received receive VBN cord-005453-4057qib7 1694 20 ≥2 ≥2 NNP cord-005453-4057qib7 1694 21 prior prior JJ cord-005453-4057qib7 1694 22 lines line NNS cord-005453-4057qib7 1694 23 of of IN cord-005453-4057qib7 1694 24 treatment treatment NN cord-005453-4057qib7 1694 25 . . . cord-005453-4057qib7 1695 1 At at IN cord-005453-4057qib7 1695 2 the the DT cord-005453-4057qib7 1695 3 time time NN cord-005453-4057qib7 1695 4 of of IN cord-005453-4057qib7 1695 5 the the DT cord-005453-4057qib7 1695 6 onset onset NN cord-005453-4057qib7 1695 7 of of IN cord-005453-4057qib7 1695 8 the the DT cord-005453-4057qib7 1695 9 BCRi BCRi NNS cord-005453-4057qib7 1695 10 , , , cord-005453-4057qib7 1695 11 7 7 CD cord-005453-4057qib7 1695 12 patients patient NNS cord-005453-4057qib7 1695 13 had have VBD cord-005453-4057qib7 1695 14 Rai Rai NNP cord-005453-4057qib7 1695 15 4 4 CD cord-005453-4057qib7 1695 16 stage stage NN cord-005453-4057qib7 1695 17 and and CC cord-005453-4057qib7 1695 18 6 6 CD cord-005453-4057qib7 1695 19 patients patient NNS cord-005453-4057qib7 1695 20 had have VBD cord-005453-4057qib7 1695 21 a a DT cord-005453-4057qib7 1695 22 lymph lymph NN cord-005453-4057qib7 1695 23 node node NN cord-005453-4057qib7 1695 24 size size NN cord-005453-4057qib7 1695 25 ≥5 ≥5 NNP cord-005453-4057qib7 1695 26 cm cm NNP cord-005453-4057qib7 1695 27 . . . cord-005453-4057qib7 1696 1 Del17p Del17p NNP cord-005453-4057qib7 1696 2 was be VBD cord-005453-4057qib7 1696 3 present present JJ cord-005453-4057qib7 1696 4 in in IN cord-005453-4057qib7 1696 5 4 4 CD cord-005453-4057qib7 1696 6 patients patient NNS cord-005453-4057qib7 1696 7 and and CC cord-005453-4057qib7 1696 8 del11q del11q NNP cord-005453-4057qib7 1696 9 and and CC cord-005453-4057qib7 1696 10 complex complex JJ cord-005453-4057qib7 1696 11 karyotype karyotype NN cord-005453-4057qib7 1696 12 in in IN cord-005453-4057qib7 1696 13 2 2 CD cord-005453-4057qib7 1696 14 patients patient NNS cord-005453-4057qib7 1696 15 , , , cord-005453-4057qib7 1696 16 respectively respectively RB cord-005453-4057qib7 1696 17 . . . cord-005453-4057qib7 1697 1 TP53 TP53 NNP cord-005453-4057qib7 1697 2 gene gene NN cord-005453-4057qib7 1697 3 mutation mutation NN cord-005453-4057qib7 1697 4 was be VBD cord-005453-4057qib7 1697 5 detected detect VBN cord-005453-4057qib7 1697 6 in in IN cord-005453-4057qib7 1697 7 3 3 CD cord-005453-4057qib7 1697 8 patients patient NNS cord-005453-4057qib7 1697 9 ( ( -LRB- cord-005453-4057qib7 1697 10 all all DT cord-005453-4057qib7 1697 11 with with IN cord-005453-4057qib7 1697 12 del17p13 del17p13 CD cord-005453-4057qib7 1697 13 ) ) -RRB- cord-005453-4057qib7 1697 14 . . . cord-005453-4057qib7 1698 1 Median median JJ cord-005453-4057qib7 1698 2 time time NN cord-005453-4057qib7 1698 3 from from IN cord-005453-4057qib7 1698 4 SCT SCT NNP cord-005453-4057qib7 1698 5 to to IN cord-005453-4057qib7 1698 6 BCRi BCRi NNP cord-005453-4057qib7 1698 7 therapy therapy NN cord-005453-4057qib7 1698 8 was be VBD cord-005453-4057qib7 1698 9 53.9 53.9 CD cord-005453-4057qib7 1698 10 months month NNS cord-005453-4057qib7 1698 11 , , , cord-005453-4057qib7 1698 12 being be VBG cord-005453-4057qib7 1698 13 shorter short JJR cord-005453-4057qib7 1698 14 in in IN cord-005453-4057qib7 1698 15 patients patient NNS cord-005453-4057qib7 1698 16 treated treat VBN cord-005453-4057qib7 1698 17 with with IN cord-005453-4057qib7 1698 18 ibrutinib ibrutinib NN cord-005453-4057qib7 1698 19 ( ( -LRB- cord-005453-4057qib7 1698 20 n=8 n=8 NN cord-005453-4057qib7 1698 21 , , , cord-005453-4057qib7 1698 22 median median JJ cord-005453-4057qib7 1698 23 51 51 CD cord-005453-4057qib7 1698 24 months month NNS cord-005453-4057qib7 1698 25 ) ) -RRB- cord-005453-4057qib7 1698 26 than than IN cord-005453-4057qib7 1698 27 in in IN cord-005453-4057qib7 1698 28 those those DT cord-005453-4057qib7 1698 29 treated treat VBN cord-005453-4057qib7 1698 30 with with IN cord-005453-4057qib7 1698 31 idealisib idealisib NNP cord-005453-4057qib7 1698 32 ( ( -LRB- cord-005453-4057qib7 1698 33 n=3 n=3 NN cord-005453-4057qib7 1698 34 , , , cord-005453-4057qib7 1698 35 median median NN cord-005453-4057qib7 1698 36 111 111 CD cord-005453-4057qib7 1698 37 months month NNS cord-005453-4057qib7 1698 38 ) ) -RRB- cord-005453-4057qib7 1698 39 . . . cord-005453-4057qib7 1699 1 Median median JJ cord-005453-4057qib7 1699 2 time time NN cord-005453-4057qib7 1699 3 on on IN cord-005453-4057qib7 1699 4 ibrutinib ibrutinib NNP cord-005453-4057qib7 1699 5 and and CC cord-005453-4057qib7 1699 6 on on IN cord-005453-4057qib7 1699 7 idelalisib idelalisib NNP cord-005453-4057qib7 1699 8 was be VBD cord-005453-4057qib7 1699 9 7.3 7.3 CD cord-005453-4057qib7 1699 10 months month NNS cord-005453-4057qib7 1699 11 ( ( -LRB- cord-005453-4057qib7 1699 12 4 4 CD cord-005453-4057qib7 1699 13 . . . cord-005453-4057qib7 1699 14 1 1 CD cord-005453-4057qib7 1699 15 - - SYM cord-005453-4057qib7 1699 16 18.8 18.8 CD cord-005453-4057qib7 1699 17 ) ) -RRB- cord-005453-4057qib7 1699 18 and and CC cord-005453-4057qib7 1699 19 6 6 CD cord-005453-4057qib7 1699 20 months month NNS cord-005453-4057qib7 1699 21 ( ( -LRB- cord-005453-4057qib7 1699 22 3.0 3.0 CD cord-005453-4057qib7 1699 23 - - HYPH cord-005453-4057qib7 1699 24 23.4 23.4 CD cord-005453-4057qib7 1699 25 ) ) -RRB- cord-005453-4057qib7 1699 26 , , , cord-005453-4057qib7 1699 27 respectively respectively RB cord-005453-4057qib7 1699 28 . . . cord-005453-4057qib7 1700 1 The the DT cord-005453-4057qib7 1700 2 best good JJS cord-005453-4057qib7 1700 3 overall overall JJ cord-005453-4057qib7 1700 4 response response NN cord-005453-4057qib7 1700 5 rate rate NN cord-005453-4057qib7 1700 6 ( ( -LRB- cord-005453-4057qib7 1700 7 ORR ORR NNP cord-005453-4057qib7 1700 8 ) ) -RRB- cord-005453-4057qib7 1700 9 obtained obtain VBN cord-005453-4057qib7 1700 10 with with IN cord-005453-4057qib7 1700 11 ibrutinib ibrutinib NNP cord-005453-4057qib7 1700 12 was be VBD cord-005453-4057qib7 1700 13 75 75 CD cord-005453-4057qib7 1700 14 % % NN cord-005453-4057qib7 1700 15 ( ( -LRB- cord-005453-4057qib7 1700 16 1 1 CD cord-005453-4057qib7 1700 17 CR cr NN cord-005453-4057qib7 1700 18 , , , cord-005453-4057qib7 1700 19 4 4 CD cord-005453-4057qib7 1700 20 PR pr NN cord-005453-4057qib7 1700 21 , , , cord-005453-4057qib7 1700 22 1 1 CD cord-005453-4057qib7 1700 23 PR+L PR+L NNP cord-005453-4057qib7 1700 24 ) ) -RRB- cord-005453-4057qib7 1700 25 whereas whereas IN cord-005453-4057qib7 1700 26 it -PRON- PRP cord-005453-4057qib7 1700 27 was be VBD cord-005453-4057qib7 1700 28 of of IN cord-005453-4057qib7 1700 29 40 40 CD cord-005453-4057qib7 1700 30 % % NN cord-005453-4057qib7 1700 31 for for IN cord-005453-4057qib7 1700 32 patients patient NNS cord-005453-4057qib7 1700 33 receiving receive VBG cord-005453-4057qib7 1700 34 idelalisib idelalisib NNP cord-005453-4057qib7 1700 35 ( ( -LRB- cord-005453-4057qib7 1700 36 1 1 CD cord-005453-4057qib7 1700 37 CR cr NN cord-005453-4057qib7 1700 38 , , , cord-005453-4057qib7 1700 39 1 1 CD cord-005453-4057qib7 1700 40 PR+L PR+L NNP cord-005453-4057qib7 1700 41 ) ) -RRB- cord-005453-4057qib7 1700 42 . . . cord-005453-4057qib7 1701 1 Among among IN cord-005453-4057qib7 1701 2 the the DT cord-005453-4057qib7 1701 3 8 8 CD cord-005453-4057qib7 1701 4 patients patient NNS cord-005453-4057qib7 1701 5 treated treat VBN cord-005453-4057qib7 1701 6 with with IN cord-005453-4057qib7 1701 7 ibrutinib ibrutinib NNP cord-005453-4057qib7 1701 8 , , , cord-005453-4057qib7 1701 9 7 7 CD cord-005453-4057qib7 1701 10 ( ( -LRB- cord-005453-4057qib7 1701 11 87.5 87.5 CD cord-005453-4057qib7 1701 12 % % NN cord-005453-4057qib7 1701 13 ) ) -RRB- cord-005453-4057qib7 1701 14 presented present VBD cord-005453-4057qib7 1701 15 an an DT cord-005453-4057qib7 1701 16 adverse adverse JJ cord-005453-4057qib7 1701 17 event event NN cord-005453-4057qib7 1701 18 ( ( -LRB- cord-005453-4057qib7 1701 19 AE AE NNP cord-005453-4057qib7 1701 20 ) ) -RRB- cord-005453-4057qib7 1701 21 , , , cord-005453-4057qib7 1701 22 being be VBG cord-005453-4057qib7 1701 23 diarrhea diarrhea NN cord-005453-4057qib7 1701 24 ( ( -LRB- cord-005453-4057qib7 1701 25 n=3 n=3 NN cord-005453-4057qib7 1701 26 ) ) -RRB- cord-005453-4057qib7 1701 27 , , , cord-005453-4057qib7 1701 28 asthenia asthenia FW cord-005453-4057qib7 1701 29 ( ( -LRB- cord-005453-4057qib7 1701 30 n=2 n=2 NNS cord-005453-4057qib7 1701 31 ) ) -RRB- cord-005453-4057qib7 1701 32 and and CC cord-005453-4057qib7 1701 33 infections infection NNS cord-005453-4057qib7 1701 34 ( ( -LRB- cord-005453-4057qib7 1701 35 n=5 n=5 RB cord-005453-4057qib7 1701 36 ) ) -RRB- cord-005453-4057qib7 1701 37 the the DT cord-005453-4057qib7 1701 38 most most RBS cord-005453-4057qib7 1701 39 frequent frequent JJ cord-005453-4057qib7 1701 40 . . . cord-005453-4057qib7 1702 1 Hypertension hypertension NN cord-005453-4057qib7 1702 2 was be VBD cord-005453-4057qib7 1702 3 seen see VBN cord-005453-4057qib7 1702 4 in in IN cord-005453-4057qib7 1702 5 1 1 CD cord-005453-4057qib7 1702 6 patient patient NN cord-005453-4057qib7 1702 7 and and CC cord-005453-4057qib7 1702 8 none none NN cord-005453-4057qib7 1702 9 patient patient NN cord-005453-4057qib7 1702 10 developed develop VBD cord-005453-4057qib7 1702 11 atrial atrial JJ cord-005453-4057qib7 1702 12 fibrillation fibrillation NN cord-005453-4057qib7 1702 13 . . . cord-005453-4057qib7 1703 1 Five five CD cord-005453-4057qib7 1703 2 patients patient NNS cord-005453-4057qib7 1703 3 stopped stop VBD cord-005453-4057qib7 1703 4 ibrutinib ibrutinib NN cord-005453-4057qib7 1703 5 treatment treatment NN cord-005453-4057qib7 1703 6 , , , cord-005453-4057qib7 1703 7 due due IN cord-005453-4057qib7 1703 8 to to IN cord-005453-4057qib7 1703 9 toxicity toxicity NN cord-005453-4057qib7 1703 10 ( ( -LRB- cord-005453-4057qib7 1703 11 n=4 n=4 NNS cord-005453-4057qib7 1703 12 ) ) -RRB- cord-005453-4057qib7 1703 13 or or CC cord-005453-4057qib7 1703 14 progression progression NN cord-005453-4057qib7 1703 15 ( ( -LRB- cord-005453-4057qib7 1703 16 n=1 n=1 FW cord-005453-4057qib7 1703 17 ) ) -RRB- cord-005453-4057qib7 1703 18 . . . cord-005453-4057qib7 1704 1 After after IN cord-005453-4057qib7 1704 2 ibrutinib ibrutinib NN cord-005453-4057qib7 1704 3 discontinuation discontinuation NN cord-005453-4057qib7 1704 4 , , , cord-005453-4057qib7 1704 5 4 4 CD cord-005453-4057qib7 1704 6 patients patient NNS cord-005453-4057qib7 1704 7 were be VBD cord-005453-4057qib7 1704 8 newly newly RB cord-005453-4057qib7 1704 9 treated treat VBN cord-005453-4057qib7 1704 10 with with IN cord-005453-4057qib7 1704 11 idelalisib idelalisib NNP cord-005453-4057qib7 1704 12 ( ( -LRB- cord-005453-4057qib7 1704 13 n=2 n=2 NNP cord-005453-4057qib7 1704 14 ) ) -RRB- cord-005453-4057qib7 1704 15 or or CC cord-005453-4057qib7 1704 16 venetoclax venetoclax NNP cord-005453-4057qib7 1704 17 ( ( -LRB- cord-005453-4057qib7 1704 18 n=2 n=2 NNS cord-005453-4057qib7 1704 19 ) ) -RRB- cord-005453-4057qib7 1704 20 . . . cord-005453-4057qib7 1705 1 All all DT cord-005453-4057qib7 1705 2 patients patient NNS cord-005453-4057qib7 1705 3 treated treat VBN cord-005453-4057qib7 1705 4 with with IN cord-005453-4057qib7 1705 5 idelalisib idelalisib NNP cord-005453-4057qib7 1705 6 developed develop VBD cord-005453-4057qib7 1705 7 at at IN cord-005453-4057qib7 1705 8 least least RBS cord-005453-4057qib7 1705 9 one one CD cord-005453-4057qib7 1705 10 AE AE NNP cord-005453-4057qib7 1705 11 , , , cord-005453-4057qib7 1705 12 being be VBG cord-005453-4057qib7 1705 13 diarrhea diarrhea NN cord-005453-4057qib7 1705 14 ( ( -LRB- cord-005453-4057qib7 1705 15 n=3 n=3 NN cord-005453-4057qib7 1705 16 ) ) -RRB- cord-005453-4057qib7 1705 17 , , , cord-005453-4057qib7 1705 18 pneumonitis pneumonitis NNP cord-005453-4057qib7 1705 19 ( ( -LRB- cord-005453-4057qib7 1705 20 n=2 n=2 NNS cord-005453-4057qib7 1705 21 ) ) -RRB- cord-005453-4057qib7 1705 22 and and CC cord-005453-4057qib7 1705 23 neutropenia neutropenia NN cord-005453-4057qib7 1705 24 ( ( -LRB- cord-005453-4057qib7 1705 25 n=2 n=2 NNS cord-005453-4057qib7 1705 26 ) ) -RRB- cord-005453-4057qib7 1706 1 the the DT cord-005453-4057qib7 1706 2 most most RBS cord-005453-4057qib7 1706 3 common common JJ cord-005453-4057qib7 1706 4 . . . cord-005453-4057qib7 1707 1 Four four CD cord-005453-4057qib7 1707 2 patients patient NNS cord-005453-4057qib7 1707 3 discontinued discontinue VBD cord-005453-4057qib7 1707 4 idelalisib idelalisib NNP cord-005453-4057qib7 1707 5 because because IN cord-005453-4057qib7 1707 6 progression progression NN cord-005453-4057qib7 1707 7 ( ( -LRB- cord-005453-4057qib7 1707 8 n=3 n=3 NN cord-005453-4057qib7 1707 9 ) ) -RRB- cord-005453-4057qib7 1707 10 or or CC cord-005453-4057qib7 1707 11 toxicity toxicity NN cord-005453-4057qib7 1707 12 ( ( -LRB- cord-005453-4057qib7 1707 13 n=1 n=1 FW cord-005453-4057qib7 1707 14 ) ) -RRB- cord-005453-4057qib7 1707 15 . . . cord-005453-4057qib7 1708 1 Venetoclax Venetoclax NNP cord-005453-4057qib7 1708 2 was be VBD cord-005453-4057qib7 1708 3 given give VBN cord-005453-4057qib7 1708 4 after after IN cord-005453-4057qib7 1708 5 idelalisib idelalisib NNP cord-005453-4057qib7 1708 6 in in IN cord-005453-4057qib7 1708 7 3 3 CD cord-005453-4057qib7 1708 8 patients patient NNS cord-005453-4057qib7 1708 9 . . . cord-005453-4057qib7 1709 1 Although although IN cord-005453-4057qib7 1709 2 acute acute JJ cord-005453-4057qib7 1709 3 and/or and/or CC cord-005453-4057qib7 1709 4 chronic chronic JJ cord-005453-4057qib7 1709 5 GVHD GVHD NNP cord-005453-4057qib7 1709 6 before before IN cord-005453-4057qib7 1709 7 BCRi BCRi NNS cord-005453-4057qib7 1709 8 was be VBD cord-005453-4057qib7 1709 9 documented document VBN cord-005453-4057qib7 1709 10 in in IN cord-005453-4057qib7 1709 11 7 7 CD cord-005453-4057qib7 1709 12 ( ( -LRB- cord-005453-4057qib7 1709 13 63.6 63.6 CD cord-005453-4057qib7 1709 14 % % NN cord-005453-4057qib7 1709 15 ) ) -RRB- cord-005453-4057qib7 1709 16 and and CC cord-005453-4057qib7 1709 17 5 5 CD cord-005453-4057qib7 1709 18 ( ( -LRB- cord-005453-4057qib7 1709 19 45.5 45.5 CD cord-005453-4057qib7 1709 20 % % NN cord-005453-4057qib7 1709 21 ) ) -RRB- cord-005453-4057qib7 1709 22 patients patient NNS cord-005453-4057qib7 1709 23 , , , cord-005453-4057qib7 1709 24 respectively respectively RB cord-005453-4057qib7 1709 25 , , , cord-005453-4057qib7 1709 26 only only RB cord-005453-4057qib7 1709 27 one one CD cord-005453-4057qib7 1709 28 patient patient NN cord-005453-4057qib7 1709 29 ( ( -LRB- cord-005453-4057qib7 1709 30 treated treat VBN cord-005453-4057qib7 1709 31 with with IN cord-005453-4057qib7 1709 32 idelalisib idelalisib NNP cord-005453-4057qib7 1709 33 ) ) -RRB- cord-005453-4057qib7 1709 34 reactivated reactivate VBD cord-005453-4057qib7 1709 35 a a DT cord-005453-4057qib7 1709 36 mild mild JJ cord-005453-4057qib7 1709 37 chronic chronic JJ cord-005453-4057qib7 1709 38 GVHD GVHD NNP cord-005453-4057qib7 1709 39 . . . cord-005453-4057qib7 1710 1 None none NN cord-005453-4057qib7 1710 2 patient patient NN cord-005453-4057qib7 1710 3 received receive VBD cord-005453-4057qib7 1710 4 infusion infusion NN cord-005453-4057qib7 1710 5 lymphocyte lymphocyte NN cord-005453-4057qib7 1710 6 from from IN cord-005453-4057qib7 1710 7 donor donor NN cord-005453-4057qib7 1710 8 after after IN cord-005453-4057qib7 1710 9 BCRi BCRi NNS cord-005453-4057qib7 1710 10 and and CC cord-005453-4057qib7 1710 11 one one CD cord-005453-4057qib7 1710 12 patient patient NN cord-005453-4057qib7 1710 13 underwent undergo VBD cord-005453-4057qib7 1710 14 a a DT cord-005453-4057qib7 1710 15 second second JJ cord-005453-4057qib7 1710 16 SCT SCT NNP cord-005453-4057qib7 1710 17 . . . cord-005453-4057qib7 1711 1 With with IN cord-005453-4057qib7 1711 2 a a DT cord-005453-4057qib7 1711 3 median median JJ cord-005453-4057qib7 1711 4 follow follow NN cord-005453-4057qib7 1711 5 - - HYPH cord-005453-4057qib7 1711 6 up up NN cord-005453-4057qib7 1711 7 of of IN cord-005453-4057qib7 1711 8 14.3 14.3 CD cord-005453-4057qib7 1711 9 months month NNS cord-005453-4057qib7 1711 10 ( ( -LRB- cord-005453-4057qib7 1711 11 5.9 5.9 CD cord-005453-4057qib7 1711 12 - - SYM cord-005453-4057qib7 1711 13 33.9 33.9 CD cord-005453-4057qib7 1711 14 ) ) -RRB- cord-005453-4057qib7 1711 15 after after IN cord-005453-4057qib7 1711 16 the the DT cord-005453-4057qib7 1711 17 onset onset NN cord-005453-4057qib7 1711 18 of of IN cord-005453-4057qib7 1711 19 the the DT cord-005453-4057qib7 1711 20 BCRi BCRi NNP cord-005453-4057qib7 1711 21 treatment treatment NN cord-005453-4057qib7 1711 22 , , , cord-005453-4057qib7 1711 23 4 4 CD cord-005453-4057qib7 1711 24 patients patient NNS cord-005453-4057qib7 1711 25 had have VBD cord-005453-4057qib7 1711 26 died die VBN cord-005453-4057qib7 1711 27 , , , cord-005453-4057qib7 1711 28 all all DT cord-005453-4057qib7 1711 29 of of IN cord-005453-4057qib7 1711 30 them -PRON- PRP cord-005453-4057qib7 1711 31 due due JJ cord-005453-4057qib7 1711 32 to to IN cord-005453-4057qib7 1711 33 CLL CLL NNP cord-005453-4057qib7 1711 34 progression progression NN cord-005453-4057qib7 1711 35 ( ( -LRB- cord-005453-4057qib7 1711 36 3 3 CD cord-005453-4057qib7 1711 37 Richter´s richter´s NN cord-005453-4057qib7 1711 38 transformation transformation NN cord-005453-4057qib7 1711 39 ) ) -RRB- cord-005453-4057qib7 1711 40 , , , cord-005453-4057qib7 1711 41 whereas whereas IN cord-005453-4057qib7 1711 42 5 5 CD cord-005453-4057qib7 1711 43 patients patient NNS cord-005453-4057qib7 1711 44 remained remain VBD cord-005453-4057qib7 1711 45 in in IN cord-005453-4057qib7 1711 46 response response NN cord-005453-4057qib7 1711 47 ( ( -LRB- cord-005453-4057qib7 1711 48 3 3 CD cord-005453-4057qib7 1711 49 CR cr NN cord-005453-4057qib7 1711 50 , , , cord-005453-4057qib7 1711 51 2 2 CD cord-005453-4057qib7 1711 52 PR pr NN cord-005453-4057qib7 1711 53 ) ) -RRB- cord-005453-4057qib7 1711 54 . . . cord-005453-4057qib7 1712 1 The the DT cord-005453-4057qib7 1712 2 overall overall JJ cord-005453-4057qib7 1712 3 survival survival NN cord-005453-4057qib7 1712 4 probability probability NN cord-005453-4057qib7 1712 5 of of IN cord-005453-4057qib7 1712 6 the the DT cord-005453-4057qib7 1712 7 whole whole JJ cord-005453-4057qib7 1712 8 series series NN cord-005453-4057qib7 1712 9 at at IN cord-005453-4057qib7 1712 10 12 12 CD cord-005453-4057qib7 1712 11 months month NNS cord-005453-4057qib7 1712 12 was be VBD cord-005453-4057qib7 1712 13 77.8 77.8 CD cord-005453-4057qib7 1712 14 % % NN cord-005453-4057qib7 1712 15 ±13.9 ±13.9 CD cord-005453-4057qib7 1712 16 % % NN cord-005453-4057qib7 1712 17 . . . cord-005453-4057qib7 1713 1 Conclusions conclusion NNS cord-005453-4057qib7 1713 2 : : : cord-005453-4057qib7 1714 1 In in IN cord-005453-4057qib7 1714 2 our -PRON- PRP$ cord-005453-4057qib7 1714 3 study study NN cord-005453-4057qib7 1714 4 , , , cord-005453-4057qib7 1714 5 ibrutinib ibrutinib NNP cord-005453-4057qib7 1714 6 and and CC cord-005453-4057qib7 1714 7 idelalisib idelalisib NNP cord-005453-4057qib7 1714 8 , , , cord-005453-4057qib7 1714 9 administered administer VBN cord-005453-4057qib7 1714 10 in in IN cord-005453-4057qib7 1714 11 CLL CLL NNP cord-005453-4057qib7 1714 12 patients patient NNS cord-005453-4057qib7 1714 13 relapsed relapse VBD cord-005453-4057qib7 1714 14 after after IN cord-005453-4057qib7 1714 15 SCT SCT NNP cord-005453-4057qib7 1714 16 did do VBD cord-005453-4057qib7 1714 17 not not RB cord-005453-4057qib7 1714 18 increase increase VB cord-005453-4057qib7 1714 19 the the DT cord-005453-4057qib7 1714 20 risk risk NN cord-005453-4057qib7 1714 21 of of IN cord-005453-4057qib7 1714 22 GVHD GVHD NNP cord-005453-4057qib7 1714 23 reactivation reactivation NN cord-005453-4057qib7 1714 24 but but CC cord-005453-4057qib7 1714 25 they -PRON- PRP cord-005453-4057qib7 1714 26 show show VBP cord-005453-4057qib7 1714 27 high high JJ cord-005453-4057qib7 1714 28 incidence incidence NN cord-005453-4057qib7 1714 29 of of IN cord-005453-4057qib7 1714 30 adverse adverse JJ cord-005453-4057qib7 1714 31 events event NNS cord-005453-4057qib7 1714 32 . . . cord-005453-4057qib7 1715 1 Nevertheless nevertheless RB cord-005453-4057qib7 1715 2 , , , cord-005453-4057qib7 1715 3 BCRi BCRi NNP cord-005453-4057qib7 1715 4 offers offer VBZ cord-005453-4057qib7 1715 5 a a DT cord-005453-4057qib7 1715 6 possibility possibility NN cord-005453-4057qib7 1715 7 of of IN cord-005453-4057qib7 1715 8 disease disease NN cord-005453-4057qib7 1715 9 control control NN cord-005453-4057qib7 1715 10 in in IN cord-005453-4057qib7 1715 11 these these DT cord-005453-4057qib7 1715 12 patients patient NNS cord-005453-4057qib7 1715 13 with with IN cord-005453-4057qib7 1715 14 poor poor JJ cord-005453-4057qib7 1715 15 prognosis prognosis NN cord-005453-4057qib7 1715 16 . . . cord-005453-4057qib7 1716 1 Further further JJ cord-005453-4057qib7 1716 2 studies study NNS cord-005453-4057qib7 1716 3 are be VBP cord-005453-4057qib7 1716 4 needed need VBN cord-005453-4057qib7 1716 5 to to TO cord-005453-4057qib7 1716 6 confirm confirm VB cord-005453-4057qib7 1716 7 these these DT cord-005453-4057qib7 1716 8 data datum NNS cord-005453-4057qib7 1716 9 . . . cord-005453-4057qib7 1717 1 Background background NN cord-005453-4057qib7 1717 2 : : : cord-005453-4057qib7 1718 1 Prior prior RB cord-005453-4057qib7 1718 2 to to IN cord-005453-4057qib7 1718 3 the the DT cord-005453-4057qib7 1718 4 introduction introduction NN cord-005453-4057qib7 1718 5 of of IN cord-005453-4057qib7 1718 6 tyrosine tyrosine NN cord-005453-4057qib7 1718 7 kinase kinase NN cord-005453-4057qib7 1718 8 inhibitors inhibitor NNS cord-005453-4057qib7 1718 9 ( ( -LRB- cord-005453-4057qib7 1718 10 TKI TKI NNP cord-005453-4057qib7 1718 11 ) ) -RRB- cord-005453-4057qib7 1718 12 , , , cord-005453-4057qib7 1718 13 median median JJ cord-005453-4057qib7 1718 14 survival survival NN cord-005453-4057qib7 1718 15 of of IN cord-005453-4057qib7 1718 16 chronic chronic JJ cord-005453-4057qib7 1718 17 phase phase NN cord-005453-4057qib7 1718 18 chronic chronic JJ cord-005453-4057qib7 1718 19 myeloid myeloid NN cord-005453-4057qib7 1718 20 leukemia leukemia NN cord-005453-4057qib7 1719 1 ( ( -LRB- cord-005453-4057qib7 1719 2 CP CP NNP cord-005453-4057qib7 1719 3 - - HYPH cord-005453-4057qib7 1719 4 CML CML NNP cord-005453-4057qib7 1719 5 ) ) -RRB- cord-005453-4057qib7 1719 6 patients patient NNS cord-005453-4057qib7 1719 7 was be VBD cord-005453-4057qib7 1719 8 approximately approximately RB cord-005453-4057qib7 1719 9 60 60 CD cord-005453-4057qib7 1719 10 months month NNS cord-005453-4057qib7 1719 11 and and CC cord-005453-4057qib7 1719 12 the the DT cord-005453-4057qib7 1719 13 standard standard JJ cord-005453-4057qib7 1719 14 treatment treatment NN cord-005453-4057qib7 1719 15 with with IN cord-005453-4057qib7 1719 16 interferon interferon NN cord-005453-4057qib7 1719 17 - - HYPH cord-005453-4057qib7 1719 18 alpha alpha NN cord-005453-4057qib7 1719 19 resulted result VBD cord-005453-4057qib7 1719 20 in in IN cord-005453-4057qib7 1719 21 complete complete JJ cord-005453-4057qib7 1719 22 cytogenetic cytogenetic JJ cord-005453-4057qib7 1719 23 responses response NNS cord-005453-4057qib7 1719 24 in in IN cord-005453-4057qib7 1719 25 about about RB cord-005453-4057qib7 1719 26 30 30 CD cord-005453-4057qib7 1719 27 % % NN cord-005453-4057qib7 1719 28 of of IN cord-005453-4057qib7 1719 29 the the DT cord-005453-4057qib7 1719 30 patients patient NNS cord-005453-4057qib7 1719 31 . . . cord-005453-4057qib7 1720 1 Autologous autologous JJ cord-005453-4057qib7 1720 2 stem stem NN cord-005453-4057qib7 1720 3 cell cell NN cord-005453-4057qib7 1720 4 transplantation transplantation NN cord-005453-4057qib7 1720 5 ( ( -LRB- cord-005453-4057qib7 1720 6 auto auto NN cord-005453-4057qib7 1720 7 - - HYPH cord-005453-4057qib7 1720 8 SCT SCT NNP cord-005453-4057qib7 1720 9 ) ) -RRB- cord-005453-4057qib7 1720 10 was be VBD cord-005453-4057qib7 1720 11 first first RB cord-005453-4057qib7 1720 12 attempted attempt VBN cord-005453-4057qib7 1720 13 for for IN cord-005453-4057qib7 1720 14 patients patient NNS cord-005453-4057qib7 1720 15 in in IN cord-005453-4057qib7 1720 16 transformation transformation NN cord-005453-4057qib7 1720 17 in in IN cord-005453-4057qib7 1720 18 order order NN cord-005453-4057qib7 1720 19 to to TO cord-005453-4057qib7 1720 20 restore restore VB cord-005453-4057qib7 1720 21 a a DT cord-005453-4057qib7 1720 22 second second JJ cord-005453-4057qib7 1720 23 CP cp NN cord-005453-4057qib7 1720 24 and and CC cord-005453-4057qib7 1720 25 was be VBD cord-005453-4057qib7 1720 26 introduced introduce VBN cord-005453-4057qib7 1720 27 secondarily secondarily RB cord-005453-4057qib7 1720 28 in in IN cord-005453-4057qib7 1720 29 CP CP NNP cord-005453-4057qib7 1720 30 to to TO cord-005453-4057qib7 1720 31 try try VB cord-005453-4057qib7 1720 32 to to TO cord-005453-4057qib7 1720 33 prolong prolong VB cord-005453-4057qib7 1720 34 the the DT cord-005453-4057qib7 1720 35 response response NN cord-005453-4057qib7 1720 36 . . . cord-005453-4057qib7 1721 1 The the DT cord-005453-4057qib7 1721 2 main main JJ cord-005453-4057qib7 1721 3 rational rational JJ cord-005453-4057qib7 1721 4 for for IN cord-005453-4057qib7 1721 5 autografting autografte VBG cord-005453-4057qib7 1721 6 in in IN cord-005453-4057qib7 1721 7 CP CP NNP cord-005453-4057qib7 1721 8 resides reside VBZ cord-005453-4057qib7 1721 9 on on IN cord-005453-4057qib7 1721 10 the the DT cord-005453-4057qib7 1721 11 reduction reduction NN cord-005453-4057qib7 1721 12 of of IN cord-005453-4057qib7 1721 13 the the DT cord-005453-4057qib7 1721 14 tumor tumor NN cord-005453-4057qib7 1721 15 burden burden NN cord-005453-4057qib7 1721 16 and and CC cord-005453-4057qib7 1721 17 the the DT cord-005453-4057qib7 1721 18 number number NN cord-005453-4057qib7 1721 19 of of IN cord-005453-4057qib7 1721 20 leukemic leukemic JJ cord-005453-4057qib7 1721 21 cells cell NNS cord-005453-4057qib7 1721 22 at at IN cord-005453-4057qib7 1721 23 risk risk NN cord-005453-4057qib7 1721 24 of of IN cord-005453-4057qib7 1721 25 developing develop VBG cord-005453-4057qib7 1721 26 blastic blastic JJ cord-005453-4057qib7 1721 27 transformation transformation NN cord-005453-4057qib7 1721 28 . . . cord-005453-4057qib7 1722 1 Nevertheless nevertheless RB cord-005453-4057qib7 1722 2 , , , cord-005453-4057qib7 1722 3 auto auto NN cord-005453-4057qib7 1722 4 - - HYPH cord-005453-4057qib7 1722 5 SCT SCT NNP cord-005453-4057qib7 1722 6 alone alone RB cord-005453-4057qib7 1722 7 was be VBD cord-005453-4057qib7 1722 8 not not RB cord-005453-4057qib7 1722 9 able able JJ cord-005453-4057qib7 1722 10 to to TO cord-005453-4057qib7 1722 11 maintain maintain VB cord-005453-4057qib7 1722 12 a a DT cord-005453-4057qib7 1722 13 long long JJ cord-005453-4057qib7 1722 14 - - HYPH cord-005453-4057qib7 1722 15 term term NN cord-005453-4057qib7 1722 16 remission remission NN cord-005453-4057qib7 1722 17 . . . cord-005453-4057qib7 1723 1 Nowadays nowadays RB cord-005453-4057qib7 1723 2 , , , cord-005453-4057qib7 1723 3 TKIs tki NNS cord-005453-4057qib7 1723 4 represent represent VBP cord-005453-4057qib7 1723 5 the the DT cord-005453-4057qib7 1723 6 state state NN cord-005453-4057qib7 1723 7 - - HYPH cord-005453-4057qib7 1723 8 of of IN cord-005453-4057qib7 1723 9 - - HYPH cord-005453-4057qib7 1723 10 the the DT cord-005453-4057qib7 1723 11 - - HYPH cord-005453-4057qib7 1723 12 art art NN cord-005453-4057qib7 1723 13 therapy therapy NN cord-005453-4057qib7 1723 14 for for IN cord-005453-4057qib7 1723 15 CML CML NNP cord-005453-4057qib7 1723 16 and and CC cord-005453-4057qib7 1723 17 the the DT cord-005453-4057qib7 1723 18 concept concept NN cord-005453-4057qib7 1723 19 of of IN cord-005453-4057qib7 1723 20 Auto Auto NNP cord-005453-4057qib7 1723 21 - - HYPH cord-005453-4057qib7 1723 22 SCT SCT NNP cord-005453-4057qib7 1723 23 has have VBZ cord-005453-4057qib7 1723 24 only only RB cord-005453-4057qib7 1723 25 little little JJ cord-005453-4057qib7 1723 26 interest interest NN cord-005453-4057qib7 1723 27 while while IN cord-005453-4057qib7 1723 28 long long JJ cord-005453-4057qib7 1723 29 - - HYPH cord-005453-4057qib7 1723 30 term term NN cord-005453-4057qib7 1723 31 follow follow NN cord-005453-4057qib7 1723 32 - - HYPH cord-005453-4057qib7 1723 33 up up NN cord-005453-4057qib7 1723 34 and and CC cord-005453-4057qib7 1723 35 outcome outcome VB cord-005453-4057qib7 1723 36 in in IN cord-005453-4057qib7 1723 37 this this DT cord-005453-4057qib7 1723 38 setting setting NN cord-005453-4057qib7 1723 39 are be VBP cord-005453-4057qib7 1723 40 currently currently RB cord-005453-4057qib7 1723 41 unknown unknown JJ cord-005453-4057qib7 1723 42 . . . cord-005453-4057qib7 1724 1 The the DT cord-005453-4057qib7 1724 2 aim aim NN cord-005453-4057qib7 1724 3 of of IN cord-005453-4057qib7 1724 4 our -PRON- PRP$ cord-005453-4057qib7 1724 5 study study NN cord-005453-4057qib7 1724 6 is be VBZ cord-005453-4057qib7 1724 7 to to TO cord-005453-4057qib7 1724 8 evaluate evaluate VB cord-005453-4057qib7 1724 9 at at IN cord-005453-4057qib7 1724 10 a a DT cord-005453-4057qib7 1724 11 first first JJ cord-005453-4057qib7 1724 12 time time NN cord-005453-4057qib7 1724 13 the the DT cord-005453-4057qib7 1724 14 longterm longterm JJ cord-005453-4057qib7 1724 15 outcome outcome NN cord-005453-4057qib7 1724 16 of of IN cord-005453-4057qib7 1724 17 CML CML NNP cord-005453-4057qib7 1724 18 patients patient NNS cord-005453-4057qib7 1724 19 who who WP cord-005453-4057qib7 1724 20 received receive VBD cord-005453-4057qib7 1724 21 auto auto NN cord-005453-4057qib7 1724 22 - - HYPH cord-005453-4057qib7 1724 23 SCT sct NN cord-005453-4057qib7 1724 24 in in IN cord-005453-4057qib7 1724 25 chronic chronic JJ cord-005453-4057qib7 1724 26 phase phase NN cord-005453-4057qib7 1724 27 , , , cord-005453-4057qib7 1724 28 and and CC cord-005453-4057qib7 1724 29 to to TO cord-005453-4057qib7 1724 30 evaluate evaluate VB cord-005453-4057qib7 1724 31 at at IN cord-005453-4057qib7 1724 32 a a DT cord-005453-4057qib7 1724 33 second second JJ cord-005453-4057qib7 1724 34 time time NN cord-005453-4057qib7 1724 35 in in IN cord-005453-4057qib7 1724 36 a a DT cord-005453-4057qib7 1724 37 subgroup subgroup NN cord-005453-4057qib7 1724 38 analysis analysis NN cord-005453-4057qib7 1724 39 , , , cord-005453-4057qib7 1724 40 the the DT cord-005453-4057qib7 1724 41 outcome outcome NN cord-005453-4057qib7 1724 42 of of IN cord-005453-4057qib7 1724 43 those those DT cord-005453-4057qib7 1724 44 who who WP cord-005453-4057qib7 1724 45 received receive VBD cord-005453-4057qib7 1724 46 TKI TKI NNP cord-005453-4057qib7 1724 47 after after IN cord-005453-4057qib7 1724 48 having have VBG cord-005453-4057qib7 1724 49 been be VBN cord-005453-4057qib7 1724 50 auto auto NN cord-005453-4057qib7 1724 51 - - HYPH cord-005453-4057qib7 1724 52 transplanted transplant VBN cord-005453-4057qib7 1724 53 , , , cord-005453-4057qib7 1724 54 mainly mainly RB cord-005453-4057qib7 1724 55 for for IN cord-005453-4057qib7 1724 56 disease disease NN cord-005453-4057qib7 1724 57 progression progression NN cord-005453-4057qib7 1724 58 / / SYM cord-005453-4057qib7 1724 59 loss loss NN cord-005453-4057qib7 1724 60 of of IN cord-005453-4057qib7 1724 61 response response NN cord-005453-4057qib7 1724 62 and/or and/or CC cord-005453-4057qib7 1724 63 to to TO cord-005453-4057qib7 1724 64 enhance enhance VB cord-005453-4057qib7 1724 65 disease disease NN cord-005453-4057qib7 1724 66 response response NN cord-005453-4057qib7 1724 67 . . . cord-005453-4057qib7 1725 1 Methods method NNS cord-005453-4057qib7 1725 2 : : : cord-005453-4057qib7 1725 3 We -PRON- PRP cord-005453-4057qib7 1725 4 found find VBD cord-005453-4057qib7 1725 5 a a DT cord-005453-4057qib7 1725 6 total total NN cord-005453-4057qib7 1725 7 of of IN cord-005453-4057qib7 1725 8 969 969 CD cord-005453-4057qib7 1725 9 patients patient NNS cord-005453-4057qib7 1725 10 who who WP cord-005453-4057qib7 1725 11 received receive VBD cord-005453-4057qib7 1725 12 auto auto NN cord-005453-4057qib7 1725 13 - - HYPH cord-005453-4057qib7 1725 14 SCT SCT NNP cord-005453-4057qib7 1725 15 for for IN cord-005453-4057qib7 1725 16 CP CP NNP cord-005453-4057qib7 1725 17 - - HYPH cord-005453-4057qib7 1725 18 CML CML NNP cord-005453-4057qib7 1725 19 in in IN cord-005453-4057qib7 1725 20 Europe Europe NNP cord-005453-4057qib7 1725 21 between between IN cord-005453-4057qib7 1725 22 years year NNS cord-005453-4057qib7 1725 23 1989 1989 CD cord-005453-4057qib7 1725 24 and and CC cord-005453-4057qib7 1725 25 2004 2004 CD cord-005453-4057qib7 1725 26 , , , cord-005453-4057qib7 1725 27 578 578 CD cord-005453-4057qib7 1725 28 ( ( -LRB- cord-005453-4057qib7 1725 29 60 60 CD cord-005453-4057qib7 1725 30 % % NN cord-005453-4057qib7 1725 31 ) ) -RRB- cord-005453-4057qib7 1725 32 were be VBD cord-005453-4057qib7 1725 33 males male NNS cord-005453-4057qib7 1725 34 , , , cord-005453-4057qib7 1725 35 median median JJ cord-005453-4057qib7 1725 36 age age NN cord-005453-4057qib7 1725 37 at at IN cord-005453-4057qib7 1725 38 auto auto NN cord-005453-4057qib7 1725 39 - - HYPH cord-005453-4057qib7 1725 40 SCT SCT NNP cord-005453-4057qib7 1725 41 was be VBD cord-005453-4057qib7 1725 42 47 47 CD cord-005453-4057qib7 1725 43 years year NNS cord-005453-4057qib7 1726 1 ( ( -LRB- cord-005453-4057qib7 1726 2 range range NN cord-005453-4057qib7 1726 3 : : : cord-005453-4057qib7 1726 4 19 19 CD cord-005453-4057qib7 1726 5 - - SYM cord-005453-4057qib7 1726 6 67 67 CD cord-005453-4057qib7 1726 7 ) ) -RRB- cord-005453-4057qib7 1726 8 , , , cord-005453-4057qib7 1726 9 the the DT cord-005453-4057qib7 1726 10 median median JJ cord-005453-4057qib7 1726 11 time time NN cord-005453-4057qib7 1726 12 between between IN cord-005453-4057qib7 1726 13 diagnosis diagnosis NN cord-005453-4057qib7 1726 14 and and CC cord-005453-4057qib7 1726 15 auto auto NN cord-005453-4057qib7 1726 16 - - HYPH cord-005453-4057qib7 1726 17 SCT SCT NNP cord-005453-4057qib7 1726 18 was be VBD cord-005453-4057qib7 1726 19 19 19 CD cord-005453-4057qib7 1726 20 months month NNS cord-005453-4057qib7 1726 21 , , , cord-005453-4057qib7 1726 22 stem stem NN cord-005453-4057qib7 1726 23 cells cell NNS cord-005453-4057qib7 1726 24 source source NN cord-005453-4057qib7 1726 25 was be VBD cord-005453-4057qib7 1726 26 peripheral peripheral JJ cord-005453-4057qib7 1726 27 blood blood NN cord-005453-4057qib7 1726 28 in in IN cord-005453-4057qib7 1726 29 84 84 CD cord-005453-4057qib7 1726 30 % % NN cord-005453-4057qib7 1726 31 of of IN cord-005453-4057qib7 1726 32 patients patient NNS cord-005453-4057qib7 1726 33 , , , cord-005453-4057qib7 1726 34 most most RBS cord-005453-4057qib7 1726 35 frequent frequent JJ cord-005453-4057qib7 1726 36 conditioning conditioning NN cord-005453-4057qib7 1726 37 regimen regimen NN cord-005453-4057qib7 1726 38 was be VBD cord-005453-4057qib7 1726 39 busulfan busulfan NN cord-005453-4057qib7 1726 40 4mg 4mg NNP cord-005453-4057qib7 1726 41 / / SYM cord-005453-4057qib7 1726 42 Kg Kg NNP cord-005453-4057qib7 1726 43 / / SYM cord-005453-4057qib7 1726 44 day day NN cord-005453-4057qib7 1726 45 4 4 CD cord-005453-4057qib7 1726 46 days day NNS cord-005453-4057qib7 1726 47 + + SYM cord-005453-4057qib7 1726 48 1 1 CD cord-005453-4057qib7 1726 49 day day NN cord-005453-4057qib7 1726 50 of of IN cord-005453-4057qib7 1726 51 melphalan melphalan NNP cord-005453-4057qib7 1726 52 140 140 CD cord-005453-4057qib7 1726 53 mg mg NNP cord-005453-4057qib7 1726 54 / / SYM cord-005453-4057qib7 1726 55 m² m² NNP cord-005453-4057qib7 1726 56 one one CD cord-005453-4057qib7 1726 57 day day NN cord-005453-4057qib7 1726 58 prior prior RB cord-005453-4057qib7 1726 59 to to IN cord-005453-4057qib7 1726 60 the the DT cord-005453-4057qib7 1726 61 cells cell NNS cord-005453-4057qib7 1726 62 reinfusion reinfusion NN cord-005453-4057qib7 1726 63 . . . cord-005453-4057qib7 1727 1 Information information NN cord-005453-4057qib7 1727 2 about about IN cord-005453-4057qib7 1727 3 receiving receive VBG cord-005453-4057qib7 1727 4 TKI TKI NNP cord-005453-4057qib7 1727 5 post post NN cord-005453-4057qib7 1727 6 auto auto NN cord-005453-4057qib7 1727 7 - - HYPH cord-005453-4057qib7 1727 8 SCT SCT NNP cord-005453-4057qib7 1727 9 was be VBD cord-005453-4057qib7 1727 10 available available JJ cord-005453-4057qib7 1727 11 only only RB cord-005453-4057qib7 1727 12 for for IN cord-005453-4057qib7 1727 13 103 103 CD cord-005453-4057qib7 1727 14 patients patient NNS cord-005453-4057qib7 1727 15 , , , cord-005453-4057qib7 1727 16 first first RB cord-005453-4057qib7 1727 17 TKI TKI NNP cord-005453-4057qib7 1727 18 was be VBD cord-005453-4057qib7 1727 19 imatinib imatinib JJ cord-005453-4057qib7 1727 20 for for IN cord-005453-4057qib7 1727 21 89 89 CD cord-005453-4057qib7 1727 22 ( ( -LRB- cord-005453-4057qib7 1727 23 86 86 CD cord-005453-4057qib7 1727 24 % % NN cord-005453-4057qib7 1727 25 ) ) -RRB- cord-005453-4057qib7 1727 26 patients patient NNS cord-005453-4057qib7 1727 27 , , , cord-005453-4057qib7 1727 28 dasatinib dasatinib NN cord-005453-4057qib7 1727 29 for for IN cord-005453-4057qib7 1727 30 8 8 CD cord-005453-4057qib7 1727 31 ( ( -LRB- cord-005453-4057qib7 1727 32 8 8 CD cord-005453-4057qib7 1727 33 % % NN cord-005453-4057qib7 1727 34 ) ) -RRB- cord-005453-4057qib7 1727 35 , , , cord-005453-4057qib7 1727 36 nilotinib nilotinib NNP cord-005453-4057qib7 1727 37 for for IN cord-005453-4057qib7 1727 38 6 6 CD cord-005453-4057qib7 1727 39 ( ( -LRB- cord-005453-4057qib7 1727 40 5 5 CD cord-005453-4057qib7 1727 41 % % NN cord-005453-4057qib7 1727 42 ) ) -RRB- cord-005453-4057qib7 1727 43 and and CC cord-005453-4057qib7 1727 44 ponatinib ponatinib NN cord-005453-4057qib7 1727 45 for for IN cord-005453-4057qib7 1727 46 one one CD cord-005453-4057qib7 1727 47 ( ( -LRB- cord-005453-4057qib7 1727 48 1 1 CD cord-005453-4057qib7 1727 49 % % NN cord-005453-4057qib7 1727 50 ) ) -RRB- cord-005453-4057qib7 1727 51 patient patient NN cord-005453-4057qib7 1727 52 . . . cord-005453-4057qib7 1728 1 Results result NNS cord-005453-4057qib7 1728 2 : : : cord-005453-4057qib7 1729 1 After after IN cord-005453-4057qib7 1729 2 a a DT cord-005453-4057qib7 1729 3 median median JJ cord-005453-4057qib7 1729 4 follow follow NN cord-005453-4057qib7 1729 5 - - HYPH cord-005453-4057qib7 1729 6 up up NN cord-005453-4057qib7 1729 7 of of IN cord-005453-4057qib7 1729 8 9.5 9.5 CD cord-005453-4057qib7 1729 9 years year NNS cord-005453-4057qib7 1729 10 ( ( -LRB- cord-005453-4057qib7 1729 11 range range NN cord-005453-4057qib7 1729 12 : : : cord-005453-4057qib7 1729 13 1 1 CD cord-005453-4057qib7 1729 14 - - SYM cord-005453-4057qib7 1729 15 27 27 CD cord-005453-4057qib7 1729 16 ) ) -RRB- cord-005453-4057qib7 1729 17 from from IN cord-005453-4057qib7 1729 18 time time NN cord-005453-4057qib7 1729 19 of of IN cord-005453-4057qib7 1729 20 auto auto NN cord-005453-4057qib7 1729 21 - - HYPH cord-005453-4057qib7 1729 22 SCT SCT NNP cord-005453-4057qib7 1729 23 for for IN cord-005453-4057qib7 1729 24 the the DT cord-005453-4057qib7 1729 25 whole whole JJ cord-005453-4057qib7 1729 26 population population NN cord-005453-4057qib7 1729 27 , , , cord-005453-4057qib7 1729 28 the the DT cord-005453-4057qib7 1729 29 probability probability NN cord-005453-4057qib7 1729 30 of of IN cord-005453-4057qib7 1729 31 overall overall JJ cord-005453-4057qib7 1729 32 survival survival NN cord-005453-4057qib7 1729 33 ( ( -LRB- cord-005453-4057qib7 1729 34 OS OS NNP cord-005453-4057qib7 1729 35 ) ) -RRB- cord-005453-4057qib7 1729 36 at at IN cord-005453-4057qib7 1729 37 10 10 CD cord-005453-4057qib7 1729 38 years year NNS cord-005453-4057qib7 1729 39 was be VBD cord-005453-4057qib7 1729 40 50 50 CD cord-005453-4057qib7 1729 41 % % NN cord-005453-4057qib7 1729 42 ( ( -LRB- cord-005453-4057qib7 1729 43 95 95 CD cord-005453-4057qib7 1729 44 % % NN cord-005453-4057qib7 1729 45 CI ci NN cord-005453-4057qib7 1729 46 : : : cord-005453-4057qib7 1729 47 46 46 CD cord-005453-4057qib7 1729 48 - - SYM cord-005453-4057qib7 1729 49 53 53 CD cord-005453-4057qib7 1729 50 ) ) -RRB- cord-005453-4057qib7 1729 51 ; ; : cord-005453-4057qib7 1729 52 there there EX cord-005453-4057qib7 1729 53 was be VBD cord-005453-4057qib7 1729 54 540 540 CD cord-005453-4057qib7 1729 55 ( ( -LRB- cord-005453-4057qib7 1729 56 56 56 CD cord-005453-4057qib7 1729 57 % % NN cord-005453-4057qib7 1729 58 ) ) -RRB- cord-005453-4057qib7 1729 59 patients patient NNS cord-005453-4057qib7 1729 60 who who WP cord-005453-4057qib7 1729 61 relapsed relapse VBD cord-005453-4057qib7 1729 62 after after IN cord-005453-4057qib7 1729 63 a a DT cord-005453-4057qib7 1729 64 median median JJ cord-005453-4057qib7 1729 65 time time NN cord-005453-4057qib7 1729 66 of of IN cord-005453-4057qib7 1729 67 16 16 CD cord-005453-4057qib7 1729 68 months month NNS cord-005453-4057qib7 1729 69 after after IN cord-005453-4057qib7 1729 70 auto auto NN cord-005453-4057qib7 1729 71 - - HYPH cord-005453-4057qib7 1729 72 SCT SCT NNP cord-005453-4057qib7 1729 73 . . . cord-005453-4057qib7 1730 1 There there EX cord-005453-4057qib7 1730 2 was be VBD cord-005453-4057qib7 1730 3 a a DT cord-005453-4057qib7 1730 4 total total NN cord-005453-4057qib7 1730 5 of of IN cord-005453-4057qib7 1730 6 530 530 CD cord-005453-4057qib7 1730 7 patients patient NNS cord-005453-4057qib7 1730 8 transplanted transplant VBN cord-005453-4057qib7 1730 9 before before IN cord-005453-4057qib7 1730 10 the the DT cord-005453-4057qib7 1730 11 TKI TKI NNP cord-005453-4057qib7 1730 12 era era NN cord-005453-4057qib7 1730 13 and and CC cord-005453-4057qib7 1730 14 survived survive VBD cord-005453-4057qib7 1730 15 until until IN cord-005453-4057qib7 1730 16 the the DT cord-005453-4057qib7 1730 17 availability availability NN cord-005453-4057qib7 1730 18 of of IN cord-005453-4057qib7 1730 19 TKIs tki NNS cord-005453-4057qib7 1730 20 . . . cord-005453-4057qib7 1731 1 When when WRB cord-005453-4057qib7 1731 2 we -PRON- PRP cord-005453-4057qib7 1731 3 performed perform VBD cord-005453-4057qib7 1731 4 a a DT cord-005453-4057qib7 1731 5 landmark landmark NN cord-005453-4057qib7 1731 6 analysis analysis NN cord-005453-4057qib7 1731 7 evaluating evaluate VBG cord-005453-4057qib7 1731 8 the the DT cord-005453-4057qib7 1731 9 outcome outcome NN cord-005453-4057qib7 1731 10 of of IN cord-005453-4057qib7 1731 11 patients patient NNS cord-005453-4057qib7 1731 12 who who WP cord-005453-4057qib7 1731 13 received receive VBD cord-005453-4057qib7 1731 14 auto auto NN cord-005453-4057qib7 1731 15 - - HYPH cord-005453-4057qib7 1731 16 SCT SCT NNP cord-005453-4057qib7 1731 17 , , , cord-005453-4057qib7 1731 18 survived survive VBD cord-005453-4057qib7 1731 19 until until IN cord-005453-4057qib7 1731 20 the the DT cord-005453-4057qib7 1731 21 TKI TKI NNP cord-005453-4057qib7 1731 22 era era NN cord-005453-4057qib7 1731 23 and and CC cord-005453-4057qib7 1731 24 received receive VBD cord-005453-4057qib7 1731 25 TKI TKI NNP cord-005453-4057qib7 1731 26 ( ( -LRB- cord-005453-4057qib7 1731 27 N=103 N=103 NNP cord-005453-4057qib7 1731 28 ) ) -RRB- cord-005453-4057qib7 1731 29 , , , cord-005453-4057qib7 1731 30 the the DT cord-005453-4057qib7 1731 31 10 10 CD cord-005453-4057qib7 1731 32 years year NNS cord-005453-4057qib7 1731 33 OS os NN cord-005453-4057qib7 1731 34 probability probability NN cord-005453-4057qib7 1731 35 of of IN cord-005453-4057qib7 1731 36 these these DT cord-005453-4057qib7 1731 37 patients patient NNS cord-005453-4057qib7 1731 38 from from IN cord-005453-4057qib7 1731 39 TKI TKI NNP cord-005453-4057qib7 1731 40 treatment treatment NN cord-005453-4057qib7 1731 41 was be VBD cord-005453-4057qib7 1731 42 70 70 CD cord-005453-4057qib7 1731 43 % % NN cord-005453-4057qib7 1731 44 ( ( -LRB- cord-005453-4057qib7 1731 45 95 95 CD cord-005453-4057qib7 1731 46 % % NN cord-005453-4057qib7 1731 47 CI ci NN cord-005453-4057qib7 1731 48 : : : cord-005453-4057qib7 1731 49 58 58 CD cord-005453-4057qib7 1731 50 - - SYM cord-005453-4057qib7 1731 51 78 78 CD cord-005453-4057qib7 1731 52 ) ) -RRB- cord-005453-4057qib7 1731 53 . . . cord-005453-4057qib7 1732 1 Additional additional JJ cord-005453-4057qib7 1732 2 data data NN cord-005453-4057qib7 1732 3 requests request NNS cord-005453-4057qib7 1732 4 will will MD cord-005453-4057qib7 1732 5 be be VB cord-005453-4057qib7 1732 6 sent send VBN cord-005453-4057qib7 1732 7 to to IN cord-005453-4057qib7 1732 8 centers center NNS cord-005453-4057qib7 1732 9 querying query VBG cord-005453-4057qib7 1732 10 about about IN cord-005453-4057qib7 1732 11 prognosis prognosis NN cord-005453-4057qib7 1732 12 , , , cord-005453-4057qib7 1732 13 molecular molecular JJ cord-005453-4057qib7 1732 14 responses response NNS cord-005453-4057qib7 1732 15 , , , cord-005453-4057qib7 1732 16 treatment treatment NN cord-005453-4057qib7 1732 17 and and CC cord-005453-4057qib7 1732 18 disease disease NN cord-005453-4057qib7 1732 19 details detail NNS cord-005453-4057qib7 1732 20 . . . cord-005453-4057qib7 1733 1 Conclusions conclusion NNS cord-005453-4057qib7 1733 2 : : : cord-005453-4057qib7 1734 1 We -PRON- PRP cord-005453-4057qib7 1734 2 demonstrate demonstrate VBP cord-005453-4057qib7 1734 3 here here RB cord-005453-4057qib7 1734 4 with with IN cord-005453-4057qib7 1734 5 these these DT cord-005453-4057qib7 1734 6 preliminary preliminary JJ cord-005453-4057qib7 1734 7 results result NNS cord-005453-4057qib7 1734 8 that that IN cord-005453-4057qib7 1734 9 the the DT cord-005453-4057qib7 1734 10 introduction introduction NN cord-005453-4057qib7 1734 11 of of IN cord-005453-4057qib7 1734 12 TKI TKI NNP cord-005453-4057qib7 1734 13 has have VBZ cord-005453-4057qib7 1734 14 improved improve VBN cord-005453-4057qib7 1734 15 survival survival NN cord-005453-4057qib7 1734 16 of of IN cord-005453-4057qib7 1734 17 CML CML NNP cord-005453-4057qib7 1734 18 patients patient NNS cord-005453-4057qib7 1734 19 . . . cord-005453-4057qib7 1735 1 In in IN cord-005453-4057qib7 1735 2 addition addition NN cord-005453-4057qib7 1735 3 , , , cord-005453-4057qib7 1735 4 patients patient NNS cord-005453-4057qib7 1735 5 who who WP cord-005453-4057qib7 1735 6 received receive VBD cord-005453-4057qib7 1735 7 auto auto NN cord-005453-4057qib7 1735 8 - - HYPH cord-005453-4057qib7 1735 9 SCT SCT NNP cord-005453-4057qib7 1735 10 , , , cord-005453-4057qib7 1735 11 survived survive VBD cord-005453-4057qib7 1735 12 until until IN cord-005453-4057qib7 1735 13 the the DT cord-005453-4057qib7 1735 14 TKI TKI NNP cord-005453-4057qib7 1735 15 era era NN cord-005453-4057qib7 1735 16 and and CC cord-005453-4057qib7 1735 17 also also RB cord-005453-4057qib7 1735 18 received receive VBD cord-005453-4057qib7 1735 19 TKI TKI NNP cord-005453-4057qib7 1735 20 , , , cord-005453-4057qib7 1735 21 had have VBD cord-005453-4057qib7 1735 22 encouraging encouraging JJ cord-005453-4057qib7 1735 23 rates rate NNS cord-005453-4057qib7 1735 24 of of IN cord-005453-4057qib7 1735 25 long long JJ cord-005453-4057qib7 1735 26 - - HYPH cord-005453-4057qib7 1735 27 term term NN cord-005453-4057qib7 1735 28 survival survival NN cord-005453-4057qib7 1735 29 . . . cord-005453-4057qib7 1736 1 An an DT cord-005453-4057qib7 1736 2 extensive extensive JJ cord-005453-4057qib7 1736 3 analysis analysis NN cord-005453-4057qib7 1736 4 will will MD cord-005453-4057qib7 1736 5 be be VB cord-005453-4057qib7 1736 6 performed perform VBN cord-005453-4057qib7 1736 7 when when WRB cord-005453-4057qib7 1736 8 additional additional JJ cord-005453-4057qib7 1736 9 data datum NNS cord-005453-4057qib7 1736 10 will will MD cord-005453-4057qib7 1736 11 be be VB cord-005453-4057qib7 1736 12 available available JJ cord-005453-4057qib7 1736 13 and and CC cord-005453-4057qib7 1736 14 the the DT cord-005453-4057qib7 1736 15 study study NN cord-005453-4057qib7 1736 16 will will MD cord-005453-4057qib7 1736 17 be be VB cord-005453-4057qib7 1736 18 updated update VBN cord-005453-4057qib7 1736 19 with with IN cord-005453-4057qib7 1736 20 more more JJR cord-005453-4057qib7 1736 21 results result NNS cord-005453-4057qib7 1736 22 . . . cord-005453-4057qib7 1737 1 Disclosure disclosure NN cord-005453-4057qib7 1737 2 : : : cord-005453-4057qib7 1737 3 Nothing nothing NN cord-005453-4057qib7 1737 4 to to TO cord-005453-4057qib7 1737 5 declare declare VB cord-005453-4057qib7 1737 6 A a DT cord-005453-4057qib7 1737 7 35 35 CD cord-005453-4057qib7 1737 8 year year NN cord-005453-4057qib7 1737 9 single single JJ cord-005453-4057qib7 1737 10 center center NN cord-005453-4057qib7 1737 11 transplant transplant NN cord-005453-4057qib7 1737 12 experience experience NN cord-005453-4057qib7 1737 13 in in IN cord-005453-4057qib7 1737 14 chronic chronic JJ cord-005453-4057qib7 1737 15 myeloid myeloid NN cord-005453-4057qib7 1737 16 leukemia leukemia NN cord-005453-4057qib7 1737 17 Background background NN cord-005453-4057qib7 1737 18 : : : cord-005453-4057qib7 1737 19 Allogeneic allogeneic NN cord-005453-4057qib7 1737 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 1737 21 stem stem NN cord-005453-4057qib7 1737 22 cell cell NN cord-005453-4057qib7 1737 23 transplantation transplantation NN cord-005453-4057qib7 1737 24 ( ( -LRB- cord-005453-4057qib7 1737 25 HSCT HSCT NNP cord-005453-4057qib7 1737 26 ) ) -RRB- cord-005453-4057qib7 1737 27 has have VBZ cord-005453-4057qib7 1737 28 been be VBN cord-005453-4057qib7 1737 29 considered consider VBN cord-005453-4057qib7 1737 30 for for IN cord-005453-4057qib7 1737 31 decades decade NNS cord-005453-4057qib7 1737 32 the the DT cord-005453-4057qib7 1737 33 only only JJ cord-005453-4057qib7 1737 34 curative curative JJ cord-005453-4057qib7 1737 35 approach approach NN cord-005453-4057qib7 1737 36 for for IN cord-005453-4057qib7 1737 37 patients patient NNS cord-005453-4057qib7 1737 38 with with IN cord-005453-4057qib7 1737 39 chronic chronic JJ cord-005453-4057qib7 1737 40 myeloid myeloid NN cord-005453-4057qib7 1737 41 leukemia leukemia NN cord-005453-4057qib7 1737 42 ( ( -LRB- cord-005453-4057qib7 1737 43 CML CML NNP cord-005453-4057qib7 1737 44 ) ) -RRB- cord-005453-4057qib7 1737 45 . . . cord-005453-4057qib7 1738 1 In in IN cord-005453-4057qib7 1738 2 the the DT cord-005453-4057qib7 1738 3 tyrosine tyrosine NN cord-005453-4057qib7 1738 4 kinase kinase NN cord-005453-4057qib7 1738 5 inhibitors inhibitor NNS cord-005453-4057qib7 1738 6 ( ( -LRB- cord-005453-4057qib7 1738 7 TKIs TKIs NNP cord-005453-4057qib7 1738 8 ) ) -RRB- cord-005453-4057qib7 1738 9 era era NN cord-005453-4057qib7 1738 10 , , , cord-005453-4057qib7 1738 11 HSCT HSCT NNP cord-005453-4057qib7 1738 12 for for IN cord-005453-4057qib7 1738 13 CML CML NNP cord-005453-4057qib7 1738 14 has have VBZ cord-005453-4057qib7 1738 15 been be VBN cord-005453-4057qib7 1738 16 reserved reserve VBN cord-005453-4057qib7 1738 17 only only RB cord-005453-4057qib7 1738 18 to to IN cord-005453-4057qib7 1738 19 patients patient NNS cord-005453-4057qib7 1738 20 not not RB cord-005453-4057qib7 1738 21 achieving achieve VBG cord-005453-4057qib7 1738 22 a a DT cord-005453-4057qib7 1738 23 cytogenetic cytogenetic JJ cord-005453-4057qib7 1738 24 remission remission NN cord-005453-4057qib7 1738 25 or or CC cord-005453-4057qib7 1738 26 showing show VBG cord-005453-4057qib7 1738 27 progressive progressive JJ cord-005453-4057qib7 1738 28 disease disease NN cord-005453-4057qib7 1738 29 after after IN cord-005453-4057qib7 1738 30 multiple multiple JJ cord-005453-4057qib7 1738 31 TKI TKI NNP cord-005453-4057qib7 1738 32 treatment treatment NN cord-005453-4057qib7 1738 33 lines line NNS cord-005453-4057qib7 1738 34 . . . cord-005453-4057qib7 1739 1 However however RB cord-005453-4057qib7 1739 2 , , , cord-005453-4057qib7 1739 3 a a DT cord-005453-4057qib7 1739 4 progressive progressive JJ cord-005453-4057qib7 1739 5 improvement improvement NN cord-005453-4057qib7 1739 6 in in IN cord-005453-4057qib7 1739 7 the the DT cord-005453-4057qib7 1739 8 long long JJ cord-005453-4057qib7 1739 9 - - HYPH cord-005453-4057qib7 1739 10 term term NN cord-005453-4057qib7 1739 11 survival survival NN cord-005453-4057qib7 1739 12 has have VBZ cord-005453-4057qib7 1739 13 been be VBN cord-005453-4057qib7 1739 14 obtained obtain VBN cord-005453-4057qib7 1739 15 in in IN cord-005453-4057qib7 1739 16 the the DT cord-005453-4057qib7 1739 17 overall overall JJ cord-005453-4057qib7 1739 18 HSCT HSCT NNP cord-005453-4057qib7 1739 19 population population NN cord-005453-4057qib7 1739 20 . . . cord-005453-4057qib7 1740 1 The the DT cord-005453-4057qib7 1740 2 present present JJ cord-005453-4057qib7 1740 3 study study NN cord-005453-4057qib7 1740 4 aimed aim VBN cord-005453-4057qib7 1740 5 at at IN cord-005453-4057qib7 1740 6 evaluating evaluate VBG cord-005453-4057qib7 1740 7 whether whether IN cord-005453-4057qib7 1740 8 in in IN cord-005453-4057qib7 1740 9 CML CML NNP cord-005453-4057qib7 1740 10 patients patient NNS cord-005453-4057qib7 1740 11 transplanted transplant VBN cord-005453-4057qib7 1740 12 at at IN cord-005453-4057qib7 1740 13 our -PRON- PRP$ cord-005453-4057qib7 1740 14 Center Center NNP cord-005453-4057qib7 1740 15 over over IN cord-005453-4057qib7 1740 16 a a DT cord-005453-4057qib7 1740 17 long long JJ cord-005453-4057qib7 1740 18 time time NN cord-005453-4057qib7 1740 19 period period NN cord-005453-4057qib7 1741 1 -from -from JJ cord-005453-4057qib7 1741 2 1983 1983 CD cord-005453-4057qib7 1741 3 to to IN cord-005453-4057qib7 1741 4 2018 2018 CD cord-005453-4057qib7 1742 1 -the -the DT cord-005453-4057qib7 1742 2 outcome outcome NN cord-005453-4057qib7 1742 3 improved improve VBD cord-005453-4057qib7 1742 4 over over IN cord-005453-4057qib7 1742 5 time time NN cord-005453-4057qib7 1742 6 . . . cord-005453-4057qib7 1743 1 Methods method NNS cord-005453-4057qib7 1743 2 : : : cord-005453-4057qib7 1744 1 136 136 CD cord-005453-4057qib7 1744 2 consecutive consecutive JJ cord-005453-4057qib7 1744 3 patients patient NNS cord-005453-4057qib7 1744 4 who who WP cord-005453-4057qib7 1744 5 underwent undergo VBD cord-005453-4057qib7 1744 6 a a DT cord-005453-4057qib7 1744 7 transplant transplant NN cord-005453-4057qib7 1744 8 between between IN cord-005453-4057qib7 1744 9 1983 1983 CD cord-005453-4057qib7 1744 10 and and CC cord-005453-4057qib7 1744 11 1999 1999 CD cord-005453-4057qib7 1744 12 were be VBD cord-005453-4057qib7 1744 13 compared compare VBN cord-005453-4057qib7 1744 14 to to IN cord-005453-4057qib7 1744 15 43 43 CD cord-005453-4057qib7 1744 16 patients patient NNS cord-005453-4057qib7 1744 17 who who WP cord-005453-4057qib7 1744 18 received receive VBD cord-005453-4057qib7 1744 19 the the DT cord-005453-4057qib7 1744 20 transplant transplant NN cord-005453-4057qib7 1744 21 between between IN cord-005453-4057qib7 1744 22 2000 2000 CD cord-005453-4057qib7 1744 23 and and CC cord-005453-4057qib7 1744 24 2018 2018 CD cord-005453-4057qib7 1744 25 . . . cord-005453-4057qib7 1745 1 Overall overall JJ cord-005453-4057qib7 1745 2 survival survival NN cord-005453-4057qib7 1745 3 ( ( -LRB- cord-005453-4057qib7 1745 4 OS OS NNP cord-005453-4057qib7 1745 5 ) ) -RRB- cord-005453-4057qib7 1745 6 , , , cord-005453-4057qib7 1745 7 leukemia leukemia NN cord-005453-4057qib7 1745 8 - - HYPH cord-005453-4057qib7 1745 9 free free JJ cord-005453-4057qib7 1745 10 survival survival NN cord-005453-4057qib7 1745 11 ( ( -LRB- cord-005453-4057qib7 1745 12 LFS LFS NNP cord-005453-4057qib7 1745 13 ) ) -RRB- cord-005453-4057qib7 1745 14 and and CC cord-005453-4057qib7 1745 15 graft graft NN cord-005453-4057qib7 1745 16 - - HYPH cord-005453-4057qib7 1745 17 leukemia leukemia NN cord-005453-4057qib7 1745 18 - - HYPH cord-005453-4057qib7 1745 19 free free JJ cord-005453-4057qib7 1745 20 survival survival NN cord-005453-4057qib7 1745 21 ( ( -LRB- cord-005453-4057qib7 1745 22 GLFS GLFS NNP cord-005453-4057qib7 1745 23 ) ) -RRB- cord-005453-4057qib7 1745 24 were be VBD cord-005453-4057qib7 1745 25 estimated estimate VBN cord-005453-4057qib7 1745 26 using use VBG cord-005453-4057qib7 1745 27 the the DT cord-005453-4057qib7 1745 28 Kaplan Kaplan NNP cord-005453-4057qib7 1745 29 - - HYPH cord-005453-4057qib7 1745 30 Meier Meier NNP cord-005453-4057qib7 1745 31 method method NN cord-005453-4057qib7 1745 32 and and CC cord-005453-4057qib7 1745 33 the the DT cord-005453-4057qib7 1745 34 log log NN cord-005453-4057qib7 1745 35 - - HYPH cord-005453-4057qib7 1745 36 rank rank NN cord-005453-4057qib7 1745 37 test test NN cord-005453-4057qib7 1745 38 was be VBD cord-005453-4057qib7 1745 39 used use VBN cord-005453-4057qib7 1745 40 to to TO cord-005453-4057qib7 1745 41 compare compare VB cord-005453-4057qib7 1745 42 risk risk NN cord-005453-4057qib7 1745 43 factors factor NNS cord-005453-4057qib7 1745 44 categories category NNS cord-005453-4057qib7 1745 45 . . . cord-005453-4057qib7 1746 1 Results result NNS cord-005453-4057qib7 1746 2 : : : cord-005453-4057qib7 1747 1 Of of IN cord-005453-4057qib7 1747 2 the the DT cord-005453-4057qib7 1747 3 179 179 CD cord-005453-4057qib7 1747 4 patients patient NNS cord-005453-4057qib7 1747 5 [ [ -LRB- cord-005453-4057qib7 1747 6 median median NN cord-005453-4057qib7 1747 7 age age NN cord-005453-4057qib7 1747 8 35 35 CD cord-005453-4057qib7 1747 9 years year NNS cord-005453-4057qib7 1747 10 ( ( -LRB- cord-005453-4057qib7 1747 11 range7 range7 NN cord-005453-4057qib7 1747 12 - - HYPH cord-005453-4057qib7 1747 13 66 66 CD cord-005453-4057qib7 1747 14 ) ) -RRB- cord-005453-4057qib7 1747 15 ] ] -RRB- cord-005453-4057qib7 1747 16 , , , cord-005453-4057qib7 1747 17 148 148 CD cord-005453-4057qib7 1747 18 ( ( -LRB- cord-005453-4057qib7 1747 19 82.7 82.7 CD cord-005453-4057qib7 1747 20 % % NN cord-005453-4057qib7 1747 21 ) ) -RRB- cord-005453-4057qib7 1747 22 were be VBD cord-005453-4057qib7 1747 23 in in IN cord-005453-4057qib7 1747 24 1 1 CD cord-005453-4057qib7 1747 25 st st NNP cord-005453-4057qib7 1747 26 or or CC cord-005453-4057qib7 1747 27 2 2 CD cord-005453-4057qib7 1747 28 nd nd NNP cord-005453-4057qib7 1747 29 chronic chronic NN cord-005453-4057qib7 1747 30 phase phase NN cord-005453-4057qib7 1747 31 , , , cord-005453-4057qib7 1747 32 25 25 CD cord-005453-4057qib7 1747 33 ( ( -LRB- cord-005453-4057qib7 1747 34 13.9 13.9 CD cord-005453-4057qib7 1747 35 % % NN cord-005453-4057qib7 1747 36 ) ) -RRB- cord-005453-4057qib7 1747 37 in in IN cord-005453-4057qib7 1747 38 accelerated accelerated JJ cord-005453-4057qib7 1747 39 phase phase NN cord-005453-4057qib7 1747 40 and and CC cord-005453-4057qib7 1747 41 six six CD cord-005453-4057qib7 1747 42 ( ( -LRB- cord-005453-4057qib7 1747 43 3.4 3.4 CD cord-005453-4057qib7 1747 44 % % NN cord-005453-4057qib7 1747 45 ) ) -RRB- cord-005453-4057qib7 1747 46 in in IN cord-005453-4057qib7 1747 47 blast blast NN cord-005453-4057qib7 1747 48 crisis crisis NN cord-005453-4057qib7 1747 49 . . . cord-005453-4057qib7 1748 1 Matched match VBN cord-005453-4057qib7 1748 2 related related JJ cord-005453-4057qib7 1748 3 donors donor NNS cord-005453-4057qib7 1748 4 and and CC cord-005453-4057qib7 1748 5 alternative alternative JJ cord-005453-4057qib7 1748 6 donors donor NNS cord-005453-4057qib7 1748 7 ( ( -LRB- cord-005453-4057qib7 1748 8 matched match VBN cord-005453-4057qib7 1748 9 unrelated unrelated JJ cord-005453-4057qib7 1748 10 donors donor NNS cord-005453-4057qib7 1748 11 , , , cord-005453-4057qib7 1748 12 cord cord NN cord-005453-4057qib7 1748 13 blood blood NN cord-005453-4057qib7 1748 14 or or CC cord-005453-4057qib7 1748 15 mismatched mismatch VBN cord-005453-4057qib7 1748 16 related related JJ cord-005453-4057qib7 1748 17 donors donor NNS cord-005453-4057qib7 1748 18 ) ) -RRB- cord-005453-4057qib7 1748 19 were be VBD cord-005453-4057qib7 1748 20 used use VBN cord-005453-4057qib7 1748 21 in in IN cord-005453-4057qib7 1748 22 156 156 CD cord-005453-4057qib7 1748 23 and and CC cord-005453-4057qib7 1748 24 23 23 CD cord-005453-4057qib7 1748 25 cases case NNS cord-005453-4057qib7 1748 26 , , , cord-005453-4057qib7 1748 27 respectively respectively RB cord-005453-4057qib7 1748 28 . . . cord-005453-4057qib7 1749 1 As as IN cord-005453-4057qib7 1749 2 stem stem NN cord-005453-4057qib7 1749 3 cell cell NN cord-005453-4057qib7 1749 4 source source NN cord-005453-4057qib7 1749 5 , , , cord-005453-4057qib7 1749 6 bone bone NN cord-005453-4057qib7 1749 7 marrow marrow NN cord-005453-4057qib7 1749 8 was be VBD cord-005453-4057qib7 1749 9 used use VBN cord-005453-4057qib7 1749 10 in in IN cord-005453-4057qib7 1749 11 142 142 CD cord-005453-4057qib7 1749 12 patients patient NNS cord-005453-4057qib7 1749 13 , , , cord-005453-4057qib7 1749 14 peripheral peripheral JJ cord-005453-4057qib7 1749 15 blood blood NN cord-005453-4057qib7 1749 16 in in IN cord-005453-4057qib7 1749 17 33 33 CD cord-005453-4057qib7 1749 18 and and CC cord-005453-4057qib7 1749 19 umbilical umbilical JJ cord-005453-4057qib7 1749 20 cord cord NN cord-005453-4057qib7 1749 21 blood blood NN cord-005453-4057qib7 1749 22 in in IN cord-005453-4057qib7 1749 23 4 4 CD cord-005453-4057qib7 1749 24 . . . cord-005453-4057qib7 1750 1 TBIbased tbibase VBN cord-005453-4057qib7 1750 2 conditioning conditioning NN cord-005453-4057qib7 1750 3 regimens regimen NNS cord-005453-4057qib7 1750 4 were be VBD cord-005453-4057qib7 1750 5 used use VBN cord-005453-4057qib7 1750 6 in in IN cord-005453-4057qib7 1750 7 89 89 CD cord-005453-4057qib7 1750 8 patients patient NNS cord-005453-4057qib7 1750 9 , , , cord-005453-4057qib7 1750 10 while while IN cord-005453-4057qib7 1750 11 in in IN cord-005453-4057qib7 1750 12 the the DT cord-005453-4057qib7 1750 13 other other JJ cord-005453-4057qib7 1750 14 90 90 CD cord-005453-4057qib7 1750 15 cases case NNS cord-005453-4057qib7 1750 16 irradiation irradiation NN cord-005453-4057qib7 1750 17 - - HYPH cord-005453-4057qib7 1750 18 free free JJ cord-005453-4057qib7 1750 19 conditioning conditioning NN cord-005453-4057qib7 1750 20 regimens regimen NNS cord-005453-4057qib7 1750 21 were be VBD cord-005453-4057qib7 1750 22 used use VBN cord-005453-4057qib7 1750 23 . . . cord-005453-4057qib7 1751 1 Both both DT cord-005453-4057qib7 1751 2 in in IN cord-005453-4057qib7 1751 3 univariate univariate JJ cord-005453-4057qib7 1751 4 and and CC cord-005453-4057qib7 1751 5 multivariate multivariate JJ cord-005453-4057qib7 1751 6 analysis analysis NN cord-005453-4057qib7 1751 7 , , , cord-005453-4057qib7 1751 8 irradiationfree irradiationfree JJ cord-005453-4057qib7 1751 9 conditioning conditioning NN cord-005453-4057qib7 1751 10 regimens regimen NNS cord-005453-4057qib7 1751 11 ( ( -LRB- cord-005453-4057qib7 1751 12 HR HR NNP cord-005453-4057qib7 1751 13 1.8 1.8 CD cord-005453-4057qib7 1751 14 ; ; : cord-005453-4057qib7 1751 15 95%CI 95%ci CD cord-005453-4057qib7 1751 16 1.1 1.1 CD cord-005453-4057qib7 1751 17 - - HYPH cord-005453-4057qib7 1751 18 3.0 3.0 CD cord-005453-4057qib7 1751 19 , , , cord-005453-4057qib7 1751 20 p=.0014 p=.0014 NNS cord-005453-4057qib7 1751 21 ) ) -RRB- cord-005453-4057qib7 1751 22 and and CC cord-005453-4057qib7 1751 23 transplants transplant NNS cord-005453-4057qib7 1751 24 performed perform VBN cord-005453-4057qib7 1751 25 in in IN cord-005453-4057qib7 1751 26 1 1 CD cord-005453-4057qib7 1751 27 st st NNP cord-005453-4057qib7 1751 28 chronic chronic NNP cord-005453-4057qib7 1751 29 phase phase NN cord-005453-4057qib7 1751 30 ( ( -LRB- cord-005453-4057qib7 1751 31 accelerate accelerate VB cord-005453-4057qib7 1751 32 phase phase NN cord-005453-4057qib7 1751 33 HR HR NNP cord-005453-4057qib7 1751 34 2.1 2.1 CD cord-005453-4057qib7 1751 35 ; ; : cord-005453-4057qib7 1751 36 95%CI 95%ci CD cord-005453-4057qib7 1751 37 1.2 1.2 CD cord-005453-4057qib7 1751 38 - - SYM cord-005453-4057qib7 1751 39 3.8 3.8 CD cord-005453-4057qib7 1751 40 , , , cord-005453-4057qib7 1751 41 p=.008 p=.008 NNP cord-005453-4057qib7 1751 42 -2 -2 NNP cord-005453-4057qib7 1751 43 nd nd NNP cord-005453-4057qib7 1751 44 chronic chronic NN cord-005453-4057qib7 1751 45 phase phase NN cord-005453-4057qib7 1751 46 HR HR NNP cord-005453-4057qib7 1751 47 4.9 4.9 CD cord-005453-4057qib7 1751 48 ; ; : cord-005453-4057qib7 1751 49 95%CI 95%ci CD cord-005453-4057qib7 1751 50 2.3 2.3 CD cord-005453-4057qib7 1751 51 - - HYPH cord-005453-4057qib7 1751 52 10.3 10.3 CD cord-005453-4057qib7 1751 53 , , , cord-005453-4057qib7 1751 54 p=.0001 p=.0001 NNP cord-005453-4057qib7 1751 55 -blast -blast NN cord-005453-4057qib7 1751 56 crisis crisis NN cord-005453-4057qib7 1751 57 HR HR NNP cord-005453-4057qib7 1751 58 2.5 2.5 CD cord-005453-4057qib7 1751 59 ; ; : cord-005453-4057qib7 1751 60 95%CI 95%ci CD cord-005453-4057qib7 1751 61 1.0 1.0 CD cord-005453-4057qib7 1751 62 - - HYPH cord-005453-4057qib7 1751 63 6.4 6.4 CD cord-005453-4057qib7 1751 64 , , , cord-005453-4057qib7 1751 65 p p NN cord-005453-4057qib7 1751 66 < < XX cord-005453-4057qib7 1751 67 .05 .05 NFP cord-005453-4057qib7 1751 68 ) ) -RRB- cord-005453-4057qib7 1751 69 were be VBD cord-005453-4057qib7 1751 70 associated associate VBN cord-005453-4057qib7 1751 71 with with IN cord-005453-4057qib7 1751 72 a a DT cord-005453-4057qib7 1751 73 better well JJR cord-005453-4057qib7 1751 74 OS os NN cord-005453-4057qib7 1751 75 . . . cord-005453-4057qib7 1752 1 Patients patient NNS cord-005453-4057qib7 1752 2 transplanted transplant VBN cord-005453-4057qib7 1752 3 before before IN cord-005453-4057qib7 1752 4 2000 2000 CD cord-005453-4057qib7 1752 5 had have VBD cord-005453-4057qib7 1752 6 a a DT cord-005453-4057qib7 1752 7 worse bad JJR cord-005453-4057qib7 1752 8 OS OS NNP cord-005453-4057qib7 1752 9 ( ( -LRB- cord-005453-4057qib7 1752 10 HR HR NNP cord-005453-4057qib7 1752 11 6.5 6.5 CD cord-005453-4057qib7 1752 12 ; ; . cord-005453-4057qib7 1753 1 95%CI 95%ci CD cord-005453-4057qib7 1753 2 2.7 2.7 CD cord-005453-4057qib7 1753 3 - - SYM cord-005453-4057qib7 1753 4 15.5 15.5 CD cord-005453-4057qib7 1753 5 , , , cord-005453-4057qib7 1753 6 p p NN cord-005453-4057qib7 1753 7 < < XX cord-005453-4057qib7 1753 8 .0001 .0001 NNP cord-005453-4057qib7 1753 9 ) ) -RRB- cord-005453-4057qib7 1753 10 and and CC cord-005453-4057qib7 1753 11 DFS DFS NNP cord-005453-4057qib7 1753 12 ( ( -LRB- cord-005453-4057qib7 1753 13 HR HR NNP cord-005453-4057qib7 1753 14 2.2 2.2 CD cord-005453-4057qib7 1753 15 ; ; : cord-005453-4057qib7 1753 16 95%CI 95%ci CD cord-005453-4057qib7 1753 17 1.0 1.0 CD cord-005453-4057qib7 1753 18 - - SYM cord-005453-4057qib7 1753 19 4.8 4.8 CD cord-005453-4057qib7 1753 20 , , , cord-005453-4057qib7 1753 21 p=.045 p=.045 NN cord-005453-4057qib7 1753 22 ) ) -RRB- cord-005453-4057qib7 1753 23 . . . cord-005453-4057qib7 1754 1 A a DT cord-005453-4057qib7 1754 2 trend trend NN cord-005453-4057qib7 1754 3 for for IN cord-005453-4057qib7 1754 4 a a DT cord-005453-4057qib7 1754 5 worse bad JJR cord-005453-4057qib7 1754 6 GLFS GLFS NNP cord-005453-4057qib7 1754 7 was be VBD cord-005453-4057qib7 1754 8 observed observe VBN cord-005453-4057qib7 1754 9 in in IN cord-005453-4057qib7 1754 10 univariate univariate JJ cord-005453-4057qib7 1754 11 analysis analysis NN cord-005453-4057qib7 1754 12 ( ( -LRB- cord-005453-4057qib7 1754 13 HR HR NNP cord-005453-4057qib7 1754 14 1.6 1.6 CD cord-005453-4057qib7 1754 15 ; ; : cord-005453-4057qib7 1754 16 95%CI 95%ci CD cord-005453-4057qib7 1754 17 1.0 1.0 CD cord-005453-4057qib7 1754 18 - - SYM cord-005453-4057qib7 1754 19 2.7 2.7 CD cord-005453-4057qib7 1754 20 , , , cord-005453-4057qib7 1754 21 p=0.05 p=0.05 NNP cord-005453-4057qib7 1754 22 ) ) -RRB- cord-005453-4057qib7 1754 23 , , , cord-005453-4057qib7 1754 24 in in IN cord-005453-4057qib7 1754 25 the the DT cord-005453-4057qib7 1754 26 first first JJ cord-005453-4057qib7 1754 27 period period NN cord-005453-4057qib7 1754 28 of of IN cord-005453-4057qib7 1754 29 observation observation NN cord-005453-4057qib7 1754 30 . . . cord-005453-4057qib7 1755 1 Conclusions conclusion NNS cord-005453-4057qib7 1755 2 : : : cord-005453-4057qib7 1756 1 Our -PRON- PRP$ cord-005453-4057qib7 1756 2 single single JJ cord-005453-4057qib7 1756 3 center center NN cord-005453-4057qib7 1756 4 experience experience NN cord-005453-4057qib7 1756 5 confirms confirm VBZ cord-005453-4057qib7 1756 6 that that IN cord-005453-4057qib7 1756 7 higher high JJR cord-005453-4057qib7 1756 8 OS OS NNP cord-005453-4057qib7 1756 9 , , , cord-005453-4057qib7 1756 10 DFS DFS NNP cord-005453-4057qib7 1756 11 and and CC cord-005453-4057qib7 1756 12 GLFS GLFS NNP cord-005453-4057qib7 1756 13 are be VBP cord-005453-4057qib7 1756 14 observed observe VBN cord-005453-4057qib7 1756 15 in in IN cord-005453-4057qib7 1756 16 CML CML NNP cord-005453-4057qib7 1756 17 patients patient NNS cord-005453-4057qib7 1756 18 allografted allografte VBN cord-005453-4057qib7 1756 19 in in IN cord-005453-4057qib7 1756 20 more more JJR cord-005453-4057qib7 1756 21 recent recent JJ cord-005453-4057qib7 1756 22 years year NNS cord-005453-4057qib7 1756 23 . . . cord-005453-4057qib7 1757 1 Improvement improvement NN cord-005453-4057qib7 1757 2 of of IN cord-005453-4057qib7 1757 3 conditioning conditioning NN cord-005453-4057qib7 1757 4 regimens regimen NNS cord-005453-4057qib7 1757 5 , , , cord-005453-4057qib7 1757 6 use use NN cord-005453-4057qib7 1757 7 of of IN cord-005453-4057qib7 1757 8 TBI tbi NN cord-005453-4057qib7 1757 9 - - HYPH cord-005453-4057qib7 1757 10 free free JJ cord-005453-4057qib7 1757 11 conditioning conditioning NN cord-005453-4057qib7 1757 12 regimens regimen NNS cord-005453-4057qib7 1757 13 and and CC cord-005453-4057qib7 1757 14 supportive supportive JJ cord-005453-4057qib7 1757 15 therapy therapy NN cord-005453-4057qib7 1757 16 , , , cord-005453-4057qib7 1757 17 have have VBP cord-005453-4057qib7 1757 18 presumably presumably RB cord-005453-4057qib7 1757 19 contributed contribute VBN cord-005453-4057qib7 1757 20 to to IN cord-005453-4057qib7 1757 21 these these DT cord-005453-4057qib7 1757 22 results result NNS cord-005453-4057qib7 1757 23 , , , cord-005453-4057qib7 1757 24 together together RB cord-005453-4057qib7 1757 25 with with IN cord-005453-4057qib7 1757 26 the the DT cord-005453-4057qib7 1757 27 more more RBR cord-005453-4057qib7 1757 28 recent recent JJ cord-005453-4057qib7 1757 29 strategy strategy NN cord-005453-4057qib7 1757 30 of of IN cord-005453-4057qib7 1757 31 close close JJ cord-005453-4057qib7 1757 32 monitoring monitoring NN cord-005453-4057qib7 1757 33 of of IN cord-005453-4057qib7 1757 34 minimal minimal JJ cord-005453-4057qib7 1757 35 residual residual JJ cord-005453-4057qib7 1757 36 disease disease NN cord-005453-4057qib7 1757 37 , , , cord-005453-4057qib7 1757 38 and and CC cord-005453-4057qib7 1757 39 prompt prompt JJ cord-005453-4057qib7 1757 40 use use NN cord-005453-4057qib7 1757 41 of of IN cord-005453-4057qib7 1757 42 TKI TKI NNP cord-005453-4057qib7 1757 43 or or CC cord-005453-4057qib7 1757 44 donor donor NN cord-005453-4057qib7 1757 45 lymphocyte lymphocyte NN cord-005453-4057qib7 1757 46 infusion infusion NN cord-005453-4057qib7 1757 47 in in IN cord-005453-4057qib7 1757 48 case case NN cord-005453-4057qib7 1757 49 of of IN cord-005453-4057qib7 1757 50 relapse relapse NN cord-005453-4057qib7 1757 51 . . . cord-005453-4057qib7 1758 1 HSCT HSCT NNP cord-005453-4057qib7 1758 2 is be VBZ cord-005453-4057qib7 1758 3 nowadays nowadays RB cord-005453-4057qib7 1758 4 a a DT cord-005453-4057qib7 1758 5 safer safe JJR cord-005453-4057qib7 1758 6 therapeutic therapeutic JJ cord-005453-4057qib7 1758 7 procedure procedure NN cord-005453-4057qib7 1758 8 in in IN cord-005453-4057qib7 1758 9 CML CML NNP cord-005453-4057qib7 1758 10 patients patient NNS cord-005453-4057qib7 1758 11 that that WDT cord-005453-4057qib7 1758 12 should should MD cord-005453-4057qib7 1758 13 be be VB cord-005453-4057qib7 1758 14 considered consider VBN cord-005453-4057qib7 1758 15 timely timely JJ cord-005453-4057qib7 1758 16 in in IN cord-005453-4057qib7 1758 17 TKI TKI NNP cord-005453-4057qib7 1758 18 - - HYPH cord-005453-4057qib7 1758 19 resistant resistant JJ cord-005453-4057qib7 1758 20 patients patient NNS cord-005453-4057qib7 1758 21 to to TO cord-005453-4057qib7 1758 22 avoid avoid VB cord-005453-4057qib7 1758 23 progression progression NN cord-005453-4057qib7 1758 24 into into IN cord-005453-4057qib7 1758 25 a a DT cord-005453-4057qib7 1758 26 more more RBR cord-005453-4057qib7 1758 27 advanced advanced JJ cord-005453-4057qib7 1758 28 disease disease NN cord-005453-4057qib7 1758 29 phase phase NN cord-005453-4057qib7 1758 30 . . . cord-005453-4057qib7 1759 1 Disclosure disclosure NN cord-005453-4057qib7 1759 2 : : : cord-005453-4057qib7 1760 1 The the DT cord-005453-4057qib7 1760 2 authors author NNS cord-005453-4057qib7 1760 3 declare declare VBP cord-005453-4057qib7 1760 4 no no DT cord-005453-4057qib7 1760 5 conflict conflict NN cord-005453-4057qib7 1760 6 of of IN cord-005453-4057qib7 1760 7 interest interest NN cord-005453-4057qib7 1760 8 . . . cord-005453-4057qib7 1761 1 Reduced reduce VBN cord-005453-4057qib7 1761 2 - - HYPH cord-005453-4057qib7 1761 3 intensity intensity NN cord-005453-4057qib7 1761 4 transplantation transplantation NN cord-005453-4057qib7 1761 5 ( ( -LRB- cord-005453-4057qib7 1761 6 RIT RIT NNP cord-005453-4057qib7 1761 7 ) ) -RRB- cord-005453-4057qib7 1761 8 in in IN cord-005453-4057qib7 1761 9 patients patient NNS cord-005453-4057qib7 1761 10 with with IN cord-005453-4057qib7 1761 11 high high JJ cord-005453-4057qib7 1761 12 - - HYPH cord-005453-4057qib7 1761 13 risk risk NN cord-005453-4057qib7 1761 14 or or CC cord-005453-4057qib7 1761 15 advanced advanced JJ cord-005453-4057qib7 1761 16 chronic chronic JJ cord-005453-4057qib7 1761 17 lymphocytic lymphocytic JJ cord-005453-4057qib7 1761 18 leukemia leukemia NN cord-005453-4057qib7 1761 19 in in IN cord-005453-4057qib7 1761 20 last last JJ cord-005453-4057qib7 1761 21 5 5 CD cord-005453-4057qib7 1761 22 years year NNS cord-005453-4057qib7 1761 23 : : : cord-005453-4057qib7 1761 24 Improvement improvement NN cord-005453-4057qib7 1761 25 of of IN cord-005453-4057qib7 1761 26 transplant transplant NN cord-005453-4057qib7 1761 27 outcomessingle outcomessingle NNP cord-005453-4057qib7 1761 28 centre centre NNP cord-005453-4057qib7 1761 29 experience experience NN cord-005453-4057qib7 1761 30 . . . cord-005453-4057qib7 1762 1 HCT HCT NNP cord-005453-4057qib7 1762 2 - - HYPH cord-005453-4057qib7 1762 3 CI CI NNP cord-005453-4057qib7 1762 4 ≥ ≥ NNP cord-005453-4057qib7 1762 5 3 3 CD cord-005453-4057qib7 1762 6 was be VBD cord-005453-4057qib7 1762 7 in in IN cord-005453-4057qib7 1762 8 20 20 CD cord-005453-4057qib7 1762 9 % % NN cord-005453-4057qib7 1762 10 of of IN cord-005453-4057qib7 1762 11 pts pt NNS cord-005453-4057qib7 1762 12 . . . cord-005453-4057qib7 1763 1 Source source NN cord-005453-4057qib7 1763 2 of of IN cord-005453-4057qib7 1763 3 stem stem NN cord-005453-4057qib7 1763 4 cells cell NNS cord-005453-4057qib7 1763 5 was be VBD cord-005453-4057qib7 1763 6 peripheral peripheral JJ cord-005453-4057qib7 1763 7 blood blood NN cord-005453-4057qib7 1763 8 in in IN cord-005453-4057qib7 1763 9 80 80 CD cord-005453-4057qib7 1763 10 % % NN cord-005453-4057qib7 1763 11 and and CC cord-005453-4057qib7 1763 12 bone bone NN cord-005453-4057qib7 1763 13 marrow marrow NN cord-005453-4057qib7 1763 14 in in IN cord-005453-4057qib7 1763 15 20 20 CD cord-005453-4057qib7 1763 16 % % NN cord-005453-4057qib7 1763 17 of of IN cord-005453-4057qib7 1763 18 pts pt NNS cord-005453-4057qib7 1763 19 . . . cord-005453-4057qib7 1764 1 The the DT cord-005453-4057qib7 1764 2 median median NN cord-005453-4057qib7 1764 3 of of IN cord-005453-4057qib7 1764 4 infused infuse VBN cord-005453-4057qib7 1764 5 CD CD NNP cord-005453-4057qib7 1764 6 34 34 CD cord-005453-4057qib7 1764 7 + + CC cord-005453-4057qib7 1764 8 cells cell NNS cord-005453-4057qib7 1764 9 was be VBD cord-005453-4057qib7 1764 10 5,4x10 5,4x10 NN cord-005453-4057qib7 1764 11 ^ ^ : cord-005453-4057qib7 1764 12 6/ 6/ CD cord-005453-4057qib7 1764 13 kg kg NNS cord-005453-4057qib7 1764 14 . . . cord-005453-4057qib7 1765 1 The the DT cord-005453-4057qib7 1765 2 conditioning conditioning NN cord-005453-4057qib7 1765 3 regimen regimen NN cord-005453-4057qib7 1765 4 consisted consist VBD cord-005453-4057qib7 1765 5 of of IN cord-005453-4057qib7 1765 6 fludarabine fludarabine NN cord-005453-4057qib7 1765 7 and and CC cord-005453-4057qib7 1765 8 melphalan melphalan NNP cord-005453-4057qib7 1765 9 ( ( -LRB- cord-005453-4057qib7 1765 10 + + CC cord-005453-4057qib7 1765 11 ATG ATG NNP cord-005453-4057qib7 1765 12 in in IN cord-005453-4057qib7 1765 13 unrelated unrelated JJ cord-005453-4057qib7 1765 14 donor donor NN cord-005453-4057qib7 1765 15 ) ) -RRB- cord-005453-4057qib7 1765 16 . . . cord-005453-4057qib7 1766 1 GVHD GVHD NNP cord-005453-4057qib7 1766 2 prophylaxis prophylaxis NN cord-005453-4057qib7 1766 3 were be VBD cord-005453-4057qib7 1766 4 cyclosporine cyclosporine JJ cord-005453-4057qib7 1766 5 and and CC cord-005453-4057qib7 1766 6 methotrexate methotrexate NNP cord-005453-4057qib7 1766 7 . . . cord-005453-4057qib7 1767 1 Results result NNS cord-005453-4057qib7 1767 2 : : : cord-005453-4057qib7 1768 1 All all DT cord-005453-4057qib7 1768 2 pts pt NNS cord-005453-4057qib7 1768 3 engrafted engraft VBD cord-005453-4057qib7 1768 4 . . . cord-005453-4057qib7 1769 1 None none NN cord-005453-4057qib7 1769 2 of of IN cord-005453-4057qib7 1769 3 3 3 CD cord-005453-4057qib7 1769 4 pts pt NNS cord-005453-4057qib7 1769 5 in in IN cord-005453-4057qib7 1769 6 CR cr NN cord-005453-4057qib7 1769 7 before before IN cord-005453-4057qib7 1769 8 RIT RIT NNP cord-005453-4057qib7 1769 9 progressed progress VBD cord-005453-4057qib7 1769 10 at at IN cord-005453-4057qib7 1769 11 day day NN cord-005453-4057qib7 1769 12 +30 +30 CD cord-005453-4057qib7 1769 13 after after IN cord-005453-4057qib7 1769 14 RIT RIT NNP cord-005453-4057qib7 1769 15 and and CC cord-005453-4057qib7 1769 16 among among IN cord-005453-4057qib7 1769 17 17 17 CD cord-005453-4057qib7 1769 18 pts pts NN cord-005453-4057qib7 1769 19 beyond beyond IN cord-005453-4057qib7 1769 20 CR CR NNP cord-005453-4057qib7 1769 21 before before IN cord-005453-4057qib7 1769 22 RIT RIT NNP cord-005453-4057qib7 1769 23 all all DT cord-005453-4057qib7 1769 24 of of IN cord-005453-4057qib7 1769 25 them -PRON- PRP cord-005453-4057qib7 1769 26 achieved achieve VBD cord-005453-4057qib7 1769 27 at at IN cord-005453-4057qib7 1769 28 least least JJS cord-005453-4057qib7 1769 29 PR PR NNP cord-005453-4057qib7 1769 30 at at IN cord-005453-4057qib7 1769 31 day day NN cord-005453-4057qib7 1769 32 +30 +30 CD cord-005453-4057qib7 1769 33 after after IN cord-005453-4057qib7 1769 34 RIT RIT NNP cord-005453-4057qib7 1769 35 . . . cord-005453-4057qib7 1770 1 13 13 CD cord-005453-4057qib7 1770 2 pts pt NNS cord-005453-4057qib7 1770 3 ( ( -LRB- cord-005453-4057qib7 1770 4 65 65 CD cord-005453-4057qib7 1770 5 % % NN cord-005453-4057qib7 1770 6 ) ) -RRB- cord-005453-4057qib7 1770 7 developed develop VBN cord-005453-4057qib7 1770 8 acute acute JJ cord-005453-4057qib7 1770 9 GVHD GVHD NNP cord-005453-4057qib7 1770 10 ( ( -LRB- cord-005453-4057qib7 1770 11 2 2 CD cord-005453-4057qib7 1770 12 pts pts NN cord-005453-4057qib7 1770 13 grade grade NN cord-005453-4057qib7 1770 14 III III NNP cord-005453-4057qib7 1770 15 - - HYPH cord-005453-4057qib7 1770 16 IV IV NNP cord-005453-4057qib7 1770 17 ) ) -RRB- cord-005453-4057qib7 1770 18 and and CC cord-005453-4057qib7 1770 19 among among IN cord-005453-4057qib7 1770 20 19 19 CD cord-005453-4057qib7 1770 21 evaluable evaluable JJ cord-005453-4057qib7 1770 22 pts pt NNS cord-005453-4057qib7 1770 23 10 10 CD cord-005453-4057qib7 1770 24 ( ( -LRB- cord-005453-4057qib7 1770 25 53 53 CD cord-005453-4057qib7 1770 26 % % NN cord-005453-4057qib7 1770 27 ) ) -RRB- cord-005453-4057qib7 1770 28 of of IN cord-005453-4057qib7 1770 29 them -PRON- PRP cord-005453-4057qib7 1770 30 developed develop VBD cord-005453-4057qib7 1770 31 chronic chronic JJ cord-005453-4057qib7 1770 32 GVHD GVHD NNP cord-005453-4057qib7 1770 33 ( ( -LRB- cord-005453-4057qib7 1770 34 6 6 CD cord-005453-4057qib7 1770 35 mild mild JJ cord-005453-4057qib7 1770 36 , , , cord-005453-4057qib7 1770 37 2 2 CD cord-005453-4057qib7 1770 38 moderate moderate JJ cord-005453-4057qib7 1770 39 , , , cord-005453-4057qib7 1770 40 2 2 CD cord-005453-4057qib7 1770 41 severe severe NN cord-005453-4057qib7 1770 42 ) ) -RRB- cord-005453-4057qib7 1770 43 . . . cord-005453-4057qib7 1771 1 With with IN cord-005453-4057qib7 1771 2 median median JJ cord-005453-4057qib7 1771 3 follow follow NN cord-005453-4057qib7 1771 4 - - HYPH cord-005453-4057qib7 1771 5 up up NN cord-005453-4057qib7 1771 6 50 50 CD cord-005453-4057qib7 1771 7 months month NNS cord-005453-4057qib7 1772 1 ( ( -LRB- cord-005453-4057qib7 1772 2 range range NNP cord-005453-4057qib7 1772 3 6 6 CD cord-005453-4057qib7 1772 4 - - SYM cord-005453-4057qib7 1772 5 63 63 CD cord-005453-4057qib7 1772 6 months month NNS cord-005453-4057qib7 1772 7 ) ) -RRB- cord-005453-4057qib7 1772 8 15 15 CD cord-005453-4057qib7 1772 9 pts pt NNS cord-005453-4057qib7 1772 10 ( ( -LRB- cord-005453-4057qib7 1772 11 75 75 CD cord-005453-4057qib7 1772 12 % % NN cord-005453-4057qib7 1772 13 ) ) -RRB- cord-005453-4057qib7 1772 14 are be VBP cord-005453-4057qib7 1772 15 alive alive JJ cord-005453-4057qib7 1772 16 in in IN cord-005453-4057qib7 1772 17 CR CR NNP cord-005453-4057qib7 1772 18 . . . cord-005453-4057qib7 1773 1 3 3 CD cord-005453-4057qib7 1773 2 pts pts NN cord-005453-4057qib7 1773 3 ( ( -LRB- cord-005453-4057qib7 1773 4 15 15 CD cord-005453-4057qib7 1773 5 % % NN cord-005453-4057qib7 1773 6 ) ) -RRB- cord-005453-4057qib7 1773 7 relapsed relapse VBN cord-005453-4057qib7 1773 8 or or CC cord-005453-4057qib7 1773 9 progressed progress VBN cord-005453-4057qib7 1773 10 5 5 CD cord-005453-4057qib7 1773 11 , , , cord-005453-4057qib7 1773 12 19 19 CD cord-005453-4057qib7 1773 13 and and CC cord-005453-4057qib7 1773 14 21 21 CD cord-005453-4057qib7 1773 15 months month NNS cord-005453-4057qib7 1773 16 after after IN cord-005453-4057qib7 1773 17 RIT RIT NNP cord-005453-4057qib7 1773 18 and and CC cord-005453-4057qib7 1773 19 2 2 CD cord-005453-4057qib7 1773 20 of of IN cord-005453-4057qib7 1773 21 them -PRON- PRP cord-005453-4057qib7 1773 22 died die VBD cord-005453-4057qib7 1773 23 . . . cord-005453-4057qib7 1774 1 Last last JJ cord-005453-4057qib7 1774 2 relapsed relapse VBN cord-005453-4057qib7 1774 3 patient patient NN cord-005453-4057qib7 1774 4 achieved achieve VBN cord-005453-4057qib7 1774 5 next next IN cord-005453-4057qib7 1774 6 CR CR NNP cord-005453-4057qib7 1774 7 after after IN cord-005453-4057qib7 1774 8 ibrutinib ibrutinib NN cord-005453-4057qib7 1774 9 . . . cord-005453-4057qib7 1775 1 3 3 CD cord-005453-4057qib7 1775 2 pts pts NN cord-005453-4057qib7 1775 3 ( ( -LRB- cord-005453-4057qib7 1775 4 15 15 CD cord-005453-4057qib7 1775 5 % % NN cord-005453-4057qib7 1775 6 ) ) -RRB- cord-005453-4057qib7 1775 7 died die VBD cord-005453-4057qib7 1775 8 due due IN cord-005453-4057qib7 1775 9 to to IN cord-005453-4057qib7 1775 10 NRM NRM NNP cord-005453-4057qib7 1775 11 . . . cord-005453-4057qib7 1776 1 NRM NRM NNP cord-005453-4057qib7 1776 2 till till IN cord-005453-4057qib7 1776 3 day day NN cord-005453-4057qib7 1776 4 +100 +100 NNS cord-005453-4057qib7 1776 5 after after IN cord-005453-4057qib7 1776 6 RIT RIT NNP cord-005453-4057qib7 1776 7 was be VBD cord-005453-4057qib7 1776 8 5 5 CD cord-005453-4057qib7 1776 9 % % NN cord-005453-4057qib7 1776 10 . . . cord-005453-4057qib7 1777 1 The the DT cord-005453-4057qib7 1777 2 estimated estimate VBN cord-005453-4057qib7 1777 3 probabilities probability NNS cord-005453-4057qib7 1777 4 of of IN cord-005453-4057qib7 1777 5 2-years 2-years CD cord-005453-4057qib7 1777 6 CGRFS CGRFS NNP cord-005453-4057qib7 1777 7 , , , cord-005453-4057qib7 1777 8 PFS PFS NNP cord-005453-4057qib7 1777 9 and and CC cord-005453-4057qib7 1777 10 OS OS NNP cord-005453-4057qib7 1777 11 are be VBP cord-005453-4057qib7 1777 12 55 55 CD cord-005453-4057qib7 1777 13 % % NN cord-005453-4057qib7 1777 14 , , , cord-005453-4057qib7 1777 15 73 73 CD cord-005453-4057qib7 1777 16 % % NN cord-005453-4057qib7 1777 17 and and CC cord-005453-4057qib7 1777 18 83 83 CD cord-005453-4057qib7 1777 19 % % NN cord-005453-4057qib7 1777 20 . . . cord-005453-4057qib7 1778 1 Conclusions conclusion NNS cord-005453-4057qib7 1778 2 : : : cord-005453-4057qib7 1779 1 In in IN cord-005453-4057qib7 1779 2 spite spite NN cord-005453-4057qib7 1779 3 of of IN cord-005453-4057qib7 1779 4 relatively relatively RB cord-005453-4057qib7 1779 5 small small JJ cord-005453-4057qib7 1779 6 number number NN cord-005453-4057qib7 1779 7 of of IN cord-005453-4057qib7 1779 8 evaluated evaluate VBN cord-005453-4057qib7 1779 9 pts pts NN cord-005453-4057qib7 1779 10 and and CC cord-005453-4057qib7 1779 11 retrospective retrospective JJ cord-005453-4057qib7 1779 12 type type NN cord-005453-4057qib7 1779 13 of of IN cord-005453-4057qib7 1779 14 analysis analysis NN cord-005453-4057qib7 1779 15 our -PRON- PRP$ cord-005453-4057qib7 1779 16 data datum NNS cord-005453-4057qib7 1779 17 show show VBP cord-005453-4057qib7 1779 18 that that IN cord-005453-4057qib7 1779 19 RIT RIT NNP cord-005453-4057qib7 1779 20 in in IN cord-005453-4057qib7 1779 21 pts pts NN cord-005453-4057qib7 1779 22 with with IN cord-005453-4057qib7 1779 23 high high JJ cord-005453-4057qib7 1779 24 - - HYPH cord-005453-4057qib7 1779 25 risk risk NN cord-005453-4057qib7 1779 26 or or CC cord-005453-4057qib7 1779 27 advanced advanced JJ cord-005453-4057qib7 1779 28 CLL CLL NNP cord-005453-4057qib7 1779 29 has have VBZ cord-005453-4057qib7 1779 30 achieved achieve VBN cord-005453-4057qib7 1779 31 promising promising JJ cord-005453-4057qib7 1779 32 results result NNS cord-005453-4057qib7 1779 33 ( ( -LRB- cord-005453-4057qib7 1780 1 2-and 2-and CD cord-005453-4057qib7 1780 2 5-years 5-years CD cord-005453-4057qib7 1780 3 PFS PFS NNP cord-005453-4057qib7 1780 4 and and CC cord-005453-4057qib7 1780 5 OS OS NNP cord-005453-4057qib7 1780 6 73 73 CD cord-005453-4057qib7 1780 7 % % NN cord-005453-4057qib7 1780 8 and and CC cord-005453-4057qib7 1780 9 55 55 CD cord-005453-4057qib7 1780 10 % % NN cord-005453-4057qib7 1780 11 resp resp NN cord-005453-4057qib7 1780 12 . . . cord-005453-4057qib7 1781 1 83 83 CD cord-005453-4057qib7 1781 2 and and CC cord-005453-4057qib7 1781 3 57 57 CD cord-005453-4057qib7 1781 4 % % NN cord-005453-4057qib7 1781 5 ) ) -RRB- cord-005453-4057qib7 1782 1 in in IN cord-005453-4057qib7 1782 2 recent recent JJ cord-005453-4057qib7 1782 3 years year NNS cord-005453-4057qib7 1782 4 and and CC cord-005453-4057qib7 1782 5 these these DT cord-005453-4057qib7 1782 6 results result NNS cord-005453-4057qib7 1782 7 are be VBP cord-005453-4057qib7 1782 8 better well JJR cord-005453-4057qib7 1782 9 than than IN cord-005453-4057qib7 1782 10 outcomes outcome NNS cord-005453-4057qib7 1782 11 of of IN cord-005453-4057qib7 1782 12 our -PRON- PRP$ cord-005453-4057qib7 1782 13 historical historical JJ cord-005453-4057qib7 1782 14 patient patient JJ cord-005453-4057qib7 1782 15 cohort cohort NN cord-005453-4057qib7 1782 16 from from IN cord-005453-4057qib7 1782 17 period period NN cord-005453-4057qib7 1782 18 2010 2010 CD cord-005453-4057qib7 1782 19 - - SYM cord-005453-4057qib7 1782 20 2012 2012 CD cord-005453-4057qib7 1783 1 ( ( -LRB- cord-005453-4057qib7 1783 2 2-and 2-and CD cord-005453-4057qib7 1783 3 5-years 5-years CD cord-005453-4057qib7 1783 4 PFS PFS NNP cord-005453-4057qib7 1783 5 41 41 CD cord-005453-4057qib7 1783 6 % % NN cord-005453-4057qib7 1783 7 and and CC cord-005453-4057qib7 1783 8 26 26 CD cord-005453-4057qib7 1783 9 % % NN cord-005453-4057qib7 1783 10 resp resp NN cord-005453-4057qib7 1783 11 . . . cord-005453-4057qib7 1784 1 OS OS NNP cord-005453-4057qib7 1784 2 56 56 CD cord-005453-4057qib7 1784 3 % % NN cord-005453-4057qib7 1784 4 and and CC cord-005453-4057qib7 1784 5 35 35 CD cord-005453-4057qib7 1784 6 % % NN cord-005453-4057qib7 1784 7 , , , cord-005453-4057qib7 1784 8 p=0.009 p=0.009 NN cord-005453-4057qib7 1784 9 ) ) -RRB- cord-005453-4057qib7 1784 10 or or CC cord-005453-4057qib7 1784 11 EBMT EBMT NNP cord-005453-4057qib7 1784 12 published publish VBD cord-005453-4057qib7 1784 13 data datum NNS cord-005453-4057qib7 1784 14 of of IN cord-005453-4057qib7 1784 15 pts pt NNS cord-005453-4057qib7 1784 16 transplanted transplant VBN cord-005453-4057qib7 1784 17 for for IN cord-005453-4057qib7 1784 18 CLL CLL NNP cord-005453-4057qib7 1784 19 in in IN cord-005453-4057qib7 1784 20 period period NN cord-005453-4057qib7 1784 21 2000 2000 CD cord-005453-4057qib7 1784 22 - - SYM cord-005453-4057qib7 1784 23 2010 2010 CD cord-005453-4057qib7 1785 1 ( ( -LRB- cord-005453-4057qib7 1785 2 2and 2and CD cord-005453-4057qib7 1785 3 5-years 5-years CD cord-005453-4057qib7 1785 4 PFS PFS NNP cord-005453-4057qib7 1785 5 46 46 CD cord-005453-4057qib7 1785 6 % % NN cord-005453-4057qib7 1785 7 and and CC cord-005453-4057qib7 1785 8 35 35 CD cord-005453-4057qib7 1785 9 % % NN cord-005453-4057qib7 1785 10 resp resp NN cord-005453-4057qib7 1785 11 . . . cord-005453-4057qib7 1786 1 OS OS NNP cord-005453-4057qib7 1786 2 62 62 CD cord-005453-4057qib7 1786 3 % % NN cord-005453-4057qib7 1786 4 and and CC cord-005453-4057qib7 1786 5 45 45 CD cord-005453-4057qib7 1786 6 % % NN cord-005453-4057qib7 1786 7 ) ) -RRB- cord-005453-4057qib7 1786 8 . . . cord-005453-4057qib7 1787 1 Current current JJ cord-005453-4057qib7 1787 2 results result NNS cord-005453-4057qib7 1787 3 of of IN cord-005453-4057qib7 1787 4 transplantation transplantation NN cord-005453-4057qib7 1787 5 should should MD cord-005453-4057qib7 1787 6 be be VB cord-005453-4057qib7 1787 7 taken take VBN cord-005453-4057qib7 1787 8 into into IN cord-005453-4057qib7 1787 9 account account NN cord-005453-4057qib7 1787 10 in in IN cord-005453-4057qib7 1787 11 our -PRON- PRP$ cord-005453-4057qib7 1787 12 future future JJ cord-005453-4057qib7 1787 13 decision decision NN cord-005453-4057qib7 1787 14 - - HYPH cord-005453-4057qib7 1787 15 making make VBG cord-005453-4057qib7 1787 16 process process NN cord-005453-4057qib7 1787 17 on on IN cord-005453-4057qib7 1787 18 indications indication NNS cord-005453-4057qib7 1787 19 for for IN cord-005453-4057qib7 1787 20 transplantation transplantation NN cord-005453-4057qib7 1787 21 in in IN cord-005453-4057qib7 1787 22 pts pts NN cord-005453-4057qib7 1787 23 with with IN cord-005453-4057qib7 1787 24 high high JJ cord-005453-4057qib7 1787 25 - - HYPH cord-005453-4057qib7 1787 26 risk risk NN cord-005453-4057qib7 1787 27 CLL CLL NNP cord-005453-4057qib7 1787 28 , , , cord-005453-4057qib7 1787 29 of of IN cord-005453-4057qib7 1787 30 course course NN cord-005453-4057qib7 1787 31 also also RB cord-005453-4057qib7 1787 32 in in IN cord-005453-4057qib7 1787 33 the the DT cord-005453-4057qib7 1787 34 context context NN cord-005453-4057qib7 1787 35 of of IN cord-005453-4057qib7 1787 36 new new JJ cord-005453-4057qib7 1787 37 or or CC cord-005453-4057qib7 1787 38 updated update VBN cord-005453-4057qib7 1787 39 results result NNS cord-005453-4057qib7 1787 40 of of IN cord-005453-4057qib7 1787 41 targeted target VBN cord-005453-4057qib7 1787 42 CLL CLL NNP cord-005453-4057qib7 1787 43 treatment treatment NN cord-005453-4057qib7 1787 44 and and CC cord-005453-4057qib7 1787 45 its -PRON- PRP$ cord-005453-4057qib7 1787 46 complications complication NNS cord-005453-4057qib7 1787 47 . . . cord-005453-4057qib7 1788 1 Disclosure disclosure NN cord-005453-4057qib7 1788 2 Methods method NNS cord-005453-4057qib7 1788 3 : : : cord-005453-4057qib7 1789 1 Retrospective retrospective JJ cord-005453-4057qib7 1789 2 data datum NNS cord-005453-4057qib7 1789 3 and and CC cord-005453-4057qib7 1789 4 treatment treatment NN cord-005453-4057qib7 1789 5 outcomes outcome NNS cord-005453-4057qib7 1789 6 were be VBD cord-005453-4057qib7 1789 7 collected collect VBN cord-005453-4057qib7 1789 8 from from IN cord-005453-4057qib7 1789 9 the the DT cord-005453-4057qib7 1789 10 Singapore Singapore NNP cord-005453-4057qib7 1789 11 Childhood Childhood NNP cord-005453-4057qib7 1789 12 Cancer Cancer NNP cord-005453-4057qib7 1789 13 Registry Registry NNP cord-005453-4057qib7 1789 14 ( ( -LRB- cord-005453-4057qib7 1789 15 SCCR SCCR NNP cord-005453-4057qib7 1789 16 ) ) -RRB- cord-005453-4057qib7 1789 17 . . . cord-005453-4057qib7 1790 1 Most Most JJS cord-005453-4057qib7 1790 2 children child NNS cord-005453-4057qib7 1790 3 with with IN cord-005453-4057qib7 1790 4 cancer cancer NN cord-005453-4057qib7 1790 5 in in IN cord-005453-4057qib7 1790 6 Singapore Singapore NNP cord-005453-4057qib7 1790 7 receive receive VBP cord-005453-4057qib7 1790 8 therapy therapy NN cord-005453-4057qib7 1790 9 at at IN cord-005453-4057qib7 1790 10 one one CD cord-005453-4057qib7 1790 11 of of IN cord-005453-4057qib7 1790 12 the the DT cord-005453-4057qib7 1790 13 two two CD cord-005453-4057qib7 1790 14 public public JJ cord-005453-4057qib7 1790 15 paediatric paediatric JJ cord-005453-4057qib7 1790 16 cancer cancer NN cord-005453-4057qib7 1790 17 centers center NNS cord-005453-4057qib7 1790 18 ( ( -LRB- cord-005453-4057qib7 1790 19 KKH KKH NNP cord-005453-4057qib7 1790 20 or or CC cord-005453-4057qib7 1790 21 NUH NUH NNP cord-005453-4057qib7 1790 22 ) ) -RRB- cord-005453-4057qib7 1790 23 . . . cord-005453-4057qib7 1791 1 A a DT cord-005453-4057qib7 1791 2 total total NN cord-005453-4057qib7 1791 3 of of IN cord-005453-4057qib7 1791 4 thirty thirty CD cord-005453-4057qib7 1791 5 two two CD cord-005453-4057qib7 1791 6 cases case NNS cord-005453-4057qib7 1791 7 were be VBD cord-005453-4057qib7 1791 8 diagnosed diagnose VBN cord-005453-4057qib7 1791 9 with with IN cord-005453-4057qib7 1791 10 CML CML NNP cord-005453-4057qib7 1791 11 and and CC cord-005453-4057qib7 1791 12 received receive VBD cord-005453-4057qib7 1791 13 treatment treatment NN cord-005453-4057qib7 1791 14 in in IN cord-005453-4057qib7 1791 15 either either DT cord-005453-4057qib7 1791 16 of of IN cord-005453-4057qib7 1791 17 these these DT cord-005453-4057qib7 1791 18 centers center NNS cord-005453-4057qib7 1791 19 over over IN cord-005453-4057qib7 1791 20 a a DT cord-005453-4057qib7 1791 21 twenty twenty CD cord-005453-4057qib7 1791 22 year year NN cord-005453-4057qib7 1791 23 period period NN cord-005453-4057qib7 1791 24 ( ( -LRB- cord-005453-4057qib7 1791 25 1997 1997 CD cord-005453-4057qib7 1791 26 ) ) -RRB- cord-005453-4057qib7 1792 1 ( ( -LRB- cord-005453-4057qib7 1792 2 1998 1998 CD cord-005453-4057qib7 1792 3 ) ) -RRB- cord-005453-4057qib7 1793 1 ( ( -LRB- cord-005453-4057qib7 1793 2 1999 1999 CD cord-005453-4057qib7 1793 3 ) ) -RRB- cord-005453-4057qib7 1794 1 ( ( -LRB- cord-005453-4057qib7 1794 2 2000 2000 CD cord-005453-4057qib7 1794 3 ) ) -RRB- cord-005453-4057qib7 1795 1 ( ( -LRB- cord-005453-4057qib7 1795 2 2001 2001 CD cord-005453-4057qib7 1795 3 ) ) -RRB- cord-005453-4057qib7 1795 4 ( ( -LRB- cord-005453-4057qib7 1795 5 2002 2002 CD cord-005453-4057qib7 1795 6 ) ) -RRB- cord-005453-4057qib7 1796 1 ( ( -LRB- cord-005453-4057qib7 1796 2 2003 2003 CD cord-005453-4057qib7 1796 3 ) ) -RRB- cord-005453-4057qib7 1797 1 ( ( -LRB- cord-005453-4057qib7 1797 2 2004 2004 CD cord-005453-4057qib7 1797 3 ) ) -RRB- cord-005453-4057qib7 1798 1 ( ( -LRB- cord-005453-4057qib7 1798 2 2005 2005 CD cord-005453-4057qib7 1798 3 ) ) -RRB- cord-005453-4057qib7 1799 1 ( ( -LRB- cord-005453-4057qib7 1799 2 2006 2006 CD cord-005453-4057qib7 1799 3 ) ) -RRB- cord-005453-4057qib7 1800 1 ( ( -LRB- cord-005453-4057qib7 1800 2 2007 2007 CD cord-005453-4057qib7 1800 3 ) ) -RRB- cord-005453-4057qib7 1801 1 ( ( -LRB- cord-005453-4057qib7 1801 2 2008 2008 CD cord-005453-4057qib7 1801 3 ) ) -RRB- cord-005453-4057qib7 1802 1 ( ( -LRB- cord-005453-4057qib7 1802 2 2009 2009 CD cord-005453-4057qib7 1802 3 ) ) -RRB- cord-005453-4057qib7 1803 1 ( ( -LRB- cord-005453-4057qib7 1803 2 2010 2010 CD cord-005453-4057qib7 1803 3 ) ) -RRB- cord-005453-4057qib7 1804 1 ( ( -LRB- cord-005453-4057qib7 1804 2 2011 2011 CD cord-005453-4057qib7 1804 3 ) ) -RRB- cord-005453-4057qib7 1805 1 ( ( -LRB- cord-005453-4057qib7 1805 2 2012 2012 CD cord-005453-4057qib7 1805 3 ) ) -RRB- cord-005453-4057qib7 1806 1 ( ( -LRB- cord-005453-4057qib7 1806 2 2013 2013 CD cord-005453-4057qib7 1806 3 ) ) -RRB- cord-005453-4057qib7 1807 1 ( ( -LRB- cord-005453-4057qib7 1807 2 2014 2014 CD cord-005453-4057qib7 1807 3 ) ) -RRB- cord-005453-4057qib7 1807 4 ( ( -LRB- cord-005453-4057qib7 1807 5 2015 2015 CD cord-005453-4057qib7 1807 6 ) ) -RRB- cord-005453-4057qib7 1807 7 ( ( -LRB- cord-005453-4057qib7 1807 8 2016 2016 CD cord-005453-4057qib7 1807 9 ) ) -RRB- cord-005453-4057qib7 1807 10 . . . cord-005453-4057qib7 1808 1 Results result NNS cord-005453-4057qib7 1808 2 : : : cord-005453-4057qib7 1809 1 The the DT cord-005453-4057qib7 1809 2 age age NN cord-005453-4057qib7 1809 3 at at IN cord-005453-4057qib7 1809 4 diagnosis diagnosis NN cord-005453-4057qib7 1809 5 of of IN cord-005453-4057qib7 1809 6 the the DT cord-005453-4057qib7 1809 7 thirty thirty CD cord-005453-4057qib7 1809 8 two two CD cord-005453-4057qib7 1809 9 children child NNS cord-005453-4057qib7 1809 10 ranged range VBD cord-005453-4057qib7 1809 11 from from IN cord-005453-4057qib7 1809 12 4 4 CD cord-005453-4057qib7 1809 13 to to TO cord-005453-4057qib7 1809 14 17 17 CD cord-005453-4057qib7 1809 15 years year NNS cord-005453-4057qib7 1809 16 ( ( -LRB- cord-005453-4057qib7 1809 17 median median JJ cord-005453-4057qib7 1809 18 12.5years 12.5years CD cord-005453-4057qib7 1809 19 ) ) -RRB- cord-005453-4057qib7 1809 20 . . . cord-005453-4057qib7 1810 1 Six six CD cord-005453-4057qib7 1810 2 patients patient NNS cord-005453-4057qib7 1810 3 in in IN cord-005453-4057qib7 1810 4 the the DT cord-005453-4057qib7 1810 5 pre pre JJ cord-005453-4057qib7 1810 6 - - JJ cord-005453-4057qib7 1810 7 TKI TKI NNP cord-005453-4057qib7 1810 8 era era NN cord-005453-4057qib7 1810 9 were be VBD cord-005453-4057qib7 1810 10 treated treat VBN cord-005453-4057qib7 1810 11 with with IN cord-005453-4057qib7 1810 12 an an DT cord-005453-4057qib7 1810 13 upfront upfront JJ cord-005453-4057qib7 1810 14 HSCT HSCT NNP cord-005453-4057qib7 1810 15 . . . cord-005453-4057qib7 1811 1 The the DT cord-005453-4057qib7 1811 2 remainder remainder NN cord-005453-4057qib7 1811 3 twenty twenty CD cord-005453-4057qib7 1811 4 six six CD cord-005453-4057qib7 1811 5 patients patient NNS cord-005453-4057qib7 1811 6 were be VBD cord-005453-4057qib7 1811 7 initially initially RB cord-005453-4057qib7 1811 8 started start VBN cord-005453-4057qib7 1811 9 on on IN cord-005453-4057qib7 1811 10 a a DT cord-005453-4057qib7 1811 11 TKI TKI NNP cord-005453-4057qib7 1811 12 . . . cord-005453-4057qib7 1812 1 Of of IN cord-005453-4057qib7 1812 2 these these DT cord-005453-4057qib7 1812 3 12/26 12/26 CD cord-005453-4057qib7 1812 4 ( ( -LRB- cord-005453-4057qib7 1812 5 46 46 CD cord-005453-4057qib7 1812 6 % % NN cord-005453-4057qib7 1812 7 ) ) -RRB- cord-005453-4057qib7 1812 8 had have VBD cord-005453-4057qib7 1812 9 a a DT cord-005453-4057qib7 1812 10 HSCT HSCT NNP cord-005453-4057qib7 1812 11 at at IN cord-005453-4057qib7 1812 12 a a DT cord-005453-4057qib7 1812 13 median median JJ cord-005453-4057qib7 1812 14 period period NN cord-005453-4057qib7 1812 15 of of IN cord-005453-4057qib7 1812 16 22.5 22.5 CD cord-005453-4057qib7 1812 17 months month NNS cord-005453-4057qib7 1812 18 from from IN cord-005453-4057qib7 1812 19 diagnosis diagnosis NN cord-005453-4057qib7 1812 20 ( ( -LRB- cord-005453-4057qib7 1812 21 range range NNP cord-005453-4057qib7 1812 22 5 5 CD cord-005453-4057qib7 1812 23 - - SYM cord-005453-4057qib7 1812 24 43 43 CD cord-005453-4057qib7 1812 25 months month NNS cord-005453-4057qib7 1812 26 ) ) -RRB- cord-005453-4057qib7 1812 27 . . . cord-005453-4057qib7 1813 1 The the DT cord-005453-4057qib7 1813 2 reason reason NN cord-005453-4057qib7 1813 3 for for IN cord-005453-4057qib7 1813 4 HSCT HSCT NNP cord-005453-4057qib7 1813 5 in in IN cord-005453-4057qib7 1813 6 ten ten CD cord-005453-4057qib7 1813 7 out out IN cord-005453-4057qib7 1813 8 of of IN cord-005453-4057qib7 1813 9 the the DT cord-005453-4057qib7 1813 10 twelve twelve CD cord-005453-4057qib7 1813 11 children child NNS cord-005453-4057qib7 1813 12 was be VBD cord-005453-4057qib7 1813 13 due due JJ cord-005453-4057qib7 1813 14 to to IN cord-005453-4057qib7 1813 15 high high JJ cord-005453-4057qib7 1813 16 risk risk NN cord-005453-4057qib7 1813 17 features feature NNS cord-005453-4057qib7 1814 1 i.e. i.e. FW cord-005453-4057qib7 1814 2 accelerated accelerated JJ cord-005453-4057qib7 1814 3 / / SYM cord-005453-4057qib7 1814 4 blastic blastic JJ cord-005453-4057qib7 1815 1 phase/ phase/ NNP cord-005453-4057qib7 1816 1 no no DT cord-005453-4057qib7 1816 2 CCR CCR NNP cord-005453-4057qib7 1816 3 / / , cord-005453-4057qib7 1816 4 no no DT cord-005453-4057qib7 1816 5 CMR CMR NNP cord-005453-4057qib7 1816 6 . . . cord-005453-4057qib7 1817 1 The the DT cord-005453-4057qib7 1817 2 remaining remain VBG cord-005453-4057qib7 1817 3 two two CD cord-005453-4057qib7 1817 4 patients patient NNS cord-005453-4057qib7 1817 5 had have VBD cord-005453-4057qib7 1817 6 a a DT cord-005453-4057qib7 1817 7 HSCT HSCT NNP cord-005453-4057qib7 1817 8 due due IN cord-005453-4057qib7 1817 9 to to IN cord-005453-4057qib7 1817 10 parent parent NN cord-005453-4057qib7 1817 11 and and CC cord-005453-4057qib7 1817 12 patient patient JJ cord-005453-4057qib7 1817 13 preference preference NN cord-005453-4057qib7 1817 14 for for IN cord-005453-4057qib7 1817 15 attempt attempt NN cord-005453-4057qib7 1817 16 at at IN cord-005453-4057qib7 1817 17 upfront upfront JJ cord-005453-4057qib7 1817 18 cure cure NN cord-005453-4057qib7 1817 19 rather rather RB cord-005453-4057qib7 1817 20 than than IN cord-005453-4057qib7 1817 21 the the DT cord-005453-4057qib7 1817 22 use use NN cord-005453-4057qib7 1817 23 of of IN cord-005453-4057qib7 1817 24 life life NN cord-005453-4057qib7 1817 25 - - HYPH cord-005453-4057qib7 1817 26 long long JJ cord-005453-4057qib7 1817 27 and and CC cord-005453-4057qib7 1817 28 expensive expensive JJ cord-005453-4057qib7 1817 29 TKI TKI NNP cord-005453-4057qib7 1817 30 therapy therapy NN cord-005453-4057qib7 1817 31 . . . cord-005453-4057qib7 1818 1 Non non JJ cord-005453-4057qib7 1818 2 - - NN cord-005453-4057qib7 1818 3 compliance compliance NN cord-005453-4057qib7 1818 4 to to IN cord-005453-4057qib7 1818 5 TKI TKI NNP cord-005453-4057qib7 1818 6 therapy therapy NN cord-005453-4057qib7 1818 7 was be VBD cord-005453-4057qib7 1818 8 a a DT cord-005453-4057qib7 1818 9 major major JJ cord-005453-4057qib7 1818 10 finding finding NN cord-005453-4057qib7 1818 11 in in IN cord-005453-4057qib7 1818 12 our -PRON- PRP$ cord-005453-4057qib7 1818 13 teenage teenage JJ cord-005453-4057qib7 1818 14 cohort cohort NN cord-005453-4057qib7 1818 15 . . . cord-005453-4057qib7 1819 1 Eleven eleven CD cord-005453-4057qib7 1819 2 of of IN cord-005453-4057qib7 1819 3 the the DT cord-005453-4057qib7 1819 4 eighteen eighteen CD cord-005453-4057qib7 1819 5 transplants transplant NNS cord-005453-4057qib7 1819 6 used use VBD cord-005453-4057qib7 1819 7 a a DT cord-005453-4057qib7 1819 8 matched match VBN cord-005453-4057qib7 1819 9 sibling sibling NN cord-005453-4057qib7 1819 10 donor donor NN cord-005453-4057qib7 1819 11 . . . cord-005453-4057qib7 1820 1 Three three CD cord-005453-4057qib7 1820 2 patients patient NNS cord-005453-4057qib7 1820 3 had have VBD cord-005453-4057qib7 1820 4 cord cord NN cord-005453-4057qib7 1820 5 blood blood NN cord-005453-4057qib7 1820 6 as as IN cord-005453-4057qib7 1820 7 their -PRON- PRP$ cord-005453-4057qib7 1820 8 stem stem NN cord-005453-4057qib7 1820 9 cell cell NN cord-005453-4057qib7 1820 10 source source NN cord-005453-4057qib7 1820 11 . . . cord-005453-4057qib7 1821 1 One one CD cord-005453-4057qib7 1821 2 patient patient NN cord-005453-4057qib7 1821 3 had have VBD cord-005453-4057qib7 1821 4 a a DT cord-005453-4057qib7 1821 5 single single JJ cord-005453-4057qib7 1821 6 antigen antigen NN cord-005453-4057qib7 1821 7 mismatched mismatch VBN cord-005453-4057qib7 1821 8 related related JJ cord-005453-4057qib7 1821 9 donor donor NN cord-005453-4057qib7 1821 10 and and CC cord-005453-4057qib7 1821 11 three three CD cord-005453-4057qib7 1821 12 patients patient NNS cord-005453-4057qib7 1821 13 had have VBD cord-005453-4057qib7 1821 14 a a DT cord-005453-4057qib7 1821 15 mismatched mismatched JJ cord-005453-4057qib7 1821 16 unrelated unrelated JJ cord-005453-4057qib7 1821 17 donor donor NN cord-005453-4057qib7 1821 18 for for IN cord-005453-4057qib7 1821 19 their -PRON- PRP$ cord-005453-4057qib7 1821 20 HSCT HSCT NNP cord-005453-4057qib7 1821 21 . . . cord-005453-4057qib7 1822 1 All all DT cord-005453-4057qib7 1822 2 patients patient NNS cord-005453-4057qib7 1822 3 except except IN cord-005453-4057qib7 1822 4 one one PRP cord-005453-4057qib7 1822 5 had have VBD cord-005453-4057qib7 1822 6 myeloablative myeloablative JJ cord-005453-4057qib7 1822 7 conditioning conditioning NN cord-005453-4057qib7 1822 8 with with IN cord-005453-4057qib7 1822 9 Busulfan Busulfan NNP cord-005453-4057qib7 1822 10 and and CC cord-005453-4057qib7 1822 11 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 1822 12 . . . cord-005453-4057qib7 1823 1 ATG ATG NNP cord-005453-4057qib7 1823 2 was be VBD cord-005453-4057qib7 1823 3 added add VBN cord-005453-4057qib7 1823 4 according accord VBG cord-005453-4057qib7 1823 5 to to IN cord-005453-4057qib7 1823 6 physician physician NN cord-005453-4057qib7 1823 7 preference preference NN cord-005453-4057qib7 1823 8 . . . cord-005453-4057qib7 1824 1 One one CD cord-005453-4057qib7 1824 2 patient patient NN cord-005453-4057qib7 1824 3 had have VBD cord-005453-4057qib7 1824 4 Cy Cy NNP cord-005453-4057qib7 1824 5 / / SYM cord-005453-4057qib7 1824 6 TBI TBI NNP cord-005453-4057qib7 1824 7 conditioning conditioning NN cord-005453-4057qib7 1824 8 because because IN cord-005453-4057qib7 1824 9 of of IN cord-005453-4057qib7 1824 10 pre pre JJ cord-005453-4057qib7 1824 11 - - JJ cord-005453-4057qib7 1824 12 transplant transplant JJ cord-005453-4057qib7 1824 13 lymphoid lymphoid NN cord-005453-4057qib7 1824 14 blast blast NN cord-005453-4057qib7 1824 15 crisis crisis NN cord-005453-4057qib7 1824 16 . . . cord-005453-4057qib7 1825 1 Anti anti JJ cord-005453-4057qib7 1825 2 GvHD GvHD NNP cord-005453-4057qib7 1825 3 medications medication NNS cord-005453-4057qib7 1825 4 included include VBD cord-005453-4057qib7 1825 5 cyclosporine/ cyclosporine/ CD cord-005453-4057qib7 1825 6 methotrexate methotrexate NNP cord-005453-4057qib7 1825 7 or or CC cord-005453-4057qib7 1825 8 tacrolimus tacrolimus NN cord-005453-4057qib7 1825 9 and and CC cord-005453-4057qib7 1825 10 methylprednisolone methylprednisolone NN cord-005453-4057qib7 1825 11 in in IN cord-005453-4057qib7 1825 12 the the DT cord-005453-4057qib7 1825 13 cord cord NN cord-005453-4057qib7 1825 14 transplant transplant NN cord-005453-4057qib7 1825 15 patients patient NNS cord-005453-4057qib7 1825 16 . . . cord-005453-4057qib7 1826 1 Six six CD cord-005453-4057qib7 1826 2 of of IN cord-005453-4057qib7 1826 3 the the DT cord-005453-4057qib7 1826 4 eighteen eighteen CD cord-005453-4057qib7 1826 5 ( ( -LRB- cord-005453-4057qib7 1826 6 33 33 CD cord-005453-4057qib7 1826 7 % % NN cord-005453-4057qib7 1826 8 ) ) -RRB- cord-005453-4057qib7 1826 9 patients patient NNS cord-005453-4057qib7 1826 10 who who WP cord-005453-4057qib7 1826 11 had have VBD cord-005453-4057qib7 1826 12 a a DT cord-005453-4057qib7 1826 13 HSCT HSCT NNP cord-005453-4057qib7 1826 14 died die VBD cord-005453-4057qib7 1826 15 . . . cord-005453-4057qib7 1827 1 Four four CD cord-005453-4057qib7 1827 2 died die VBD cord-005453-4057qib7 1827 3 due due IN cord-005453-4057qib7 1827 4 to to IN cord-005453-4057qib7 1827 5 treatment treatment NN cord-005453-4057qib7 1827 6 related relate VBN cord-005453-4057qib7 1827 7 mortality mortality NN cord-005453-4057qib7 1827 8 ( ( -LRB- cord-005453-4057qib7 1827 9 2 2 CD cord-005453-4057qib7 1827 10 infections infection NNS cord-005453-4057qib7 1827 11 , , , cord-005453-4057qib7 1827 12 1 1 CD cord-005453-4057qib7 1827 13 Acute acute JJ cord-005453-4057qib7 1827 14 GvHD gvhd NN cord-005453-4057qib7 1827 15 and and CC cord-005453-4057qib7 1827 16 1 1 CD cord-005453-4057qib7 1827 17 pulmonary pulmonary JJ cord-005453-4057qib7 1827 18 fibrosis fibrosis NN cord-005453-4057qib7 1827 19 ) ) -RRB- cord-005453-4057qib7 1827 20 . . . cord-005453-4057qib7 1828 1 One one CD cord-005453-4057qib7 1828 2 patient patient NN cord-005453-4057qib7 1828 3 died die VBD cord-005453-4057qib7 1828 4 due due IN cord-005453-4057qib7 1828 5 to to IN cord-005453-4057qib7 1828 6 an an DT cord-005453-4057qib7 1828 7 early early JJ cord-005453-4057qib7 1828 8 relapse relapse NN cord-005453-4057qib7 1828 9 and and CC cord-005453-4057qib7 1828 10 one one CD cord-005453-4057qib7 1828 11 had have VBD cord-005453-4057qib7 1828 12 a a DT cord-005453-4057qib7 1828 13 late late JJ cord-005453-4057qib7 1828 14 relapse relapse NN cord-005453-4057qib7 1828 15 related relate VBN cord-005453-4057qib7 1828 16 mortality mortality NN cord-005453-4057qib7 1828 17 . . . cord-005453-4057qib7 1829 1 For for IN cord-005453-4057qib7 1829 2 the the DT cord-005453-4057qib7 1829 3 pre pre JJ cord-005453-4057qib7 1829 4 - - JJ cord-005453-4057qib7 1829 5 TKI TKI NNP cord-005453-4057qib7 1829 6 era era NN cord-005453-4057qib7 1829 7 , , , cord-005453-4057qib7 1829 8 HSCT HSCT NNP cord-005453-4057qib7 1829 9 related relate VBD cord-005453-4057qib7 1829 10 5 5 CD cord-005453-4057qib7 1829 11 and and CC cord-005453-4057qib7 1829 12 10 10 CD cord-005453-4057qib7 1829 13 year year NN cord-005453-4057qib7 1829 14 OS OS NNP cord-005453-4057qib7 1829 15 was be VBD cord-005453-4057qib7 1829 16 83 83 CD cord-005453-4057qib7 1829 17 % % NN cord-005453-4057qib7 1829 18 and and CC cord-005453-4057qib7 1829 19 67 67 CD cord-005453-4057qib7 1829 20 % % NN cord-005453-4057qib7 1829 21 respectively respectively RB cord-005453-4057qib7 1829 22 . . . cord-005453-4057qib7 1830 1 Post Post NNP cord-005453-4057qib7 1830 2 - - NNP cord-005453-4057qib7 1830 3 TKI TKI NNP cord-005453-4057qib7 1830 4 era era NN cord-005453-4057qib7 1830 5 5 5 CD cord-005453-4057qib7 1830 6 and and CC cord-005453-4057qib7 1830 7 10 10 CD cord-005453-4057qib7 1830 8 year year NN cord-005453-4057qib7 1831 1 OS OS NNP cord-005453-4057qib7 1831 2 was be VBD cord-005453-4057qib7 1831 3 75 75 CD cord-005453-4057qib7 1831 4 % % NN cord-005453-4057qib7 1831 5 . . . cord-005453-4057qib7 1832 1 For for IN cord-005453-4057qib7 1832 2 the the DT cord-005453-4057qib7 1832 3 entire entire JJ cord-005453-4057qib7 1832 4 cohort cohort NN cord-005453-4057qib7 1832 5 , , , cord-005453-4057qib7 1832 6 the the DT cord-005453-4057qib7 1832 7 10 10 CD cord-005453-4057qib7 1832 8 year year NN cord-005453-4057qib7 1832 9 OS OS NNP cord-005453-4057qib7 1832 10 was be VBD cord-005453-4057qib7 1832 11 70 70 CD cord-005453-4057qib7 1832 12 % % NN cord-005453-4057qib7 1832 13 . . . cord-005453-4057qib7 1833 1 Conclusions conclusion NNS cord-005453-4057qib7 1833 2 : : : cord-005453-4057qib7 1834 1 The the DT cord-005453-4057qib7 1834 2 post post JJ cord-005453-4057qib7 1834 3 - - JJ cord-005453-4057qib7 1834 4 TKI tki JJ cord-005453-4057qib7 1834 5 era era NN cord-005453-4057qib7 1834 6 transplant transplant NN cord-005453-4057qib7 1834 7 outcomes outcome NNS cord-005453-4057qib7 1834 8 from from IN cord-005453-4057qib7 1834 9 our -PRON- PRP$ cord-005453-4057qib7 1834 10 two two CD cord-005453-4057qib7 1834 11 centers center NNS cord-005453-4057qib7 1834 12 is be VBZ cord-005453-4057qib7 1834 13 comparable comparable JJ cord-005453-4057qib7 1834 14 to to IN cord-005453-4057qib7 1834 15 leading lead VBG cord-005453-4057qib7 1834 16 centers center NNS cord-005453-4057qib7 1834 17 in in IN cord-005453-4057qib7 1834 18 the the DT cord-005453-4057qib7 1834 19 world world NN cord-005453-4057qib7 1834 20 . . . cord-005453-4057qib7 1835 1 Outcomes outcome NNS cord-005453-4057qib7 1835 2 for for IN cord-005453-4057qib7 1835 3 patients patient NNS cord-005453-4057qib7 1835 4 with with IN cord-005453-4057qib7 1835 5 mismatched mismatched JJ cord-005453-4057qib7 1835 6 unrelated unrelated JJ cord-005453-4057qib7 1835 7 donors donor NNS cord-005453-4057qib7 1835 8 was be VBD cord-005453-4057qib7 1835 9 poor poor JJ cord-005453-4057qib7 1835 10 in in IN cord-005453-4057qib7 1835 11 our -PRON- PRP$ cord-005453-4057qib7 1835 12 cohort cohort NN cord-005453-4057qib7 1835 13 . . . cord-005453-4057qib7 1836 1 We -PRON- PRP cord-005453-4057qib7 1836 2 recommend recommend VBP cord-005453-4057qib7 1836 3 a a DT cord-005453-4057qib7 1836 4 haploidentical haploidentical JJ cord-005453-4057qib7 1836 5 related related JJ cord-005453-4057qib7 1836 6 donor donor NN cord-005453-4057qib7 1836 7 transplant transplant NN cord-005453-4057qib7 1836 8 or or CC cord-005453-4057qib7 1836 9 an an DT cord-005453-4057qib7 1836 10 unrelated unrelated JJ cord-005453-4057qib7 1836 11 cord cord NN cord-005453-4057qib7 1836 12 blood blood NN cord-005453-4057qib7 1836 13 stem stem NN cord-005453-4057qib7 1836 14 cell cell NN cord-005453-4057qib7 1836 15 source source NN cord-005453-4057qib7 1836 16 for for IN cord-005453-4057qib7 1836 17 patients patient NNS cord-005453-4057qib7 1836 18 when when WRB cord-005453-4057qib7 1836 19 a a DT cord-005453-4057qib7 1836 20 matched match VBN cord-005453-4057qib7 1836 21 sibling sibling NN cord-005453-4057qib7 1836 22 or or CC cord-005453-4057qib7 1836 23 unrelated unrelated JJ cord-005453-4057qib7 1836 24 donor donor NN cord-005453-4057qib7 1836 25 is be VBZ cord-005453-4057qib7 1836 26 not not RB cord-005453-4057qib7 1836 27 available available JJ cord-005453-4057qib7 1836 28 . . . cord-005453-4057qib7 1837 1 Clinical clinical JJ cord-005453-4057qib7 1837 2 Trial Trial NNP cord-005453-4057qib7 1837 3 Registry Registry NNP cord-005453-4057qib7 1837 4 : : : cord-005453-4057qib7 1838 1 NA NA NNP cord-005453-4057qib7 1838 2 Disclosure Disclosure NNP cord-005453-4057qib7 1838 3 : : : cord-005453-4057qib7 1839 1 We -PRON- PRP cord-005453-4057qib7 1839 2 have have VBP cord-005453-4057qib7 1839 3 nothing nothing NN cord-005453-4057qib7 1839 4 to to TO cord-005453-4057qib7 1839 5 disclose disclose VB cord-005453-4057qib7 1839 6 . . . cord-005453-4057qib7 1840 1 Fludarabine Fludarabine NNP cord-005453-4057qib7 1840 2 , , , cord-005453-4057qib7 1840 3 busulfan busulfan NN cord-005453-4057qib7 1840 4 , , , cord-005453-4057qib7 1840 5 and and CC cord-005453-4057qib7 1840 6 thiotepa thiotepa NNP cord-005453-4057qib7 1840 7 may may MD cord-005453-4057qib7 1840 8 be be VB cord-005453-4057qib7 1840 9 a a DT cord-005453-4057qib7 1840 10 promising promising JJ cord-005453-4057qib7 1840 11 conditioning conditioning NN cord-005453-4057qib7 1840 12 regimen regimen NN cord-005453-4057qib7 1840 13 for for IN cord-005453-4057qib7 1840 14 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 1840 15 patients patient NNS cord-005453-4057qib7 1840 16 undergoing undergo VBG cord-005453-4057qib7 1840 17 allogeneic allogeneic IN cord-005453-4057qib7 1840 18 stem stem NN cord-005453-4057qib7 1840 19 cell cell NN cord-005453-4057qib7 1840 20 transplantation transplantation NN cord-005453-4057qib7 1840 21 Background background NN cord-005453-4057qib7 1840 22 : : : cord-005453-4057qib7 1841 1 Allogeneic allogeneic IN cord-005453-4057qib7 1841 2 stem stem NN cord-005453-4057qib7 1841 3 - - HYPH cord-005453-4057qib7 1841 4 cell cell NN cord-005453-4057qib7 1841 5 transplantation transplantation NN cord-005453-4057qib7 1841 6 ( ( -LRB- cord-005453-4057qib7 1841 7 SCT SCT NNP cord-005453-4057qib7 1841 8 ) ) -RRB- cord-005453-4057qib7 1841 9 is be VBZ cord-005453-4057qib7 1841 10 a a DT cord-005453-4057qib7 1841 11 curative curative JJ cord-005453-4057qib7 1841 12 therapy therapy NN cord-005453-4057qib7 1841 13 for for IN cord-005453-4057qib7 1841 14 patients patient NNS cord-005453-4057qib7 1841 15 with with IN cord-005453-4057qib7 1841 16 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 1841 17 . . . cord-005453-4057qib7 1842 1 However however RB cord-005453-4057qib7 1842 2 , , , cord-005453-4057qib7 1842 3 recurrent recurrent JJ cord-005453-4057qib7 1842 4 disease disease NN cord-005453-4057qib7 1842 5 and and CC cord-005453-4057qib7 1842 6 non non JJ cord-005453-4057qib7 1842 7 - - JJ cord-005453-4057qib7 1842 8 relapse relapse JJ cord-005453-4057qib7 1842 9 mortality mortality NN cord-005453-4057qib7 1842 10 ( ( -LRB- cord-005453-4057qib7 1842 11 NRM NRM NNP cord-005453-4057qib7 1842 12 ) ) -RRB- cord-005453-4057qib7 1842 13 are be VBP cord-005453-4057qib7 1842 14 frequent frequent JJ cord-005453-4057qib7 1842 15 causes cause NNS cord-005453-4057qib7 1842 16 of of IN cord-005453-4057qib7 1842 17 treatment treatment NN cord-005453-4057qib7 1842 18 failure failure NN cord-005453-4057qib7 1842 19 . . . cord-005453-4057qib7 1843 1 The the DT cord-005453-4057qib7 1843 2 optimal optimal JJ cord-005453-4057qib7 1843 3 conditioning conditioning NN cord-005453-4057qib7 1843 4 regimen regimen NN cord-005453-4057qib7 1843 5 for for IN cord-005453-4057qib7 1843 6 SCT SCT NNP cord-005453-4057qib7 1843 7 in in IN cord-005453-4057qib7 1843 8 this this DT cord-005453-4057qib7 1843 9 disease disease NN cord-005453-4057qib7 1843 10 has have VBZ cord-005453-4057qib7 1843 11 not not RB cord-005453-4057qib7 1843 12 been be VBN cord-005453-4057qib7 1843 13 defined define VBN cord-005453-4057qib7 1843 14 . . . cord-005453-4057qib7 1844 1 Methods method NNS cord-005453-4057qib7 1844 2 : : : cord-005453-4057qib7 1844 3 We -PRON- PRP cord-005453-4057qib7 1844 4 retrospectively retrospectively RB cord-005453-4057qib7 1844 5 analyzed analyze VBD cord-005453-4057qib7 1844 6 transplantation transplantation NN cord-005453-4057qib7 1844 7 outcomes outcome NNS cord-005453-4057qib7 1844 8 of of IN cord-005453-4057qib7 1844 9 all all DT cord-005453-4057qib7 1844 10 adult adult NN cord-005453-4057qib7 1844 11 patients patient NNS cord-005453-4057qib7 1844 12 given give VBN cord-005453-4057qib7 1844 13 SCT SCT NNP cord-005453-4057qib7 1844 14 for for IN cord-005453-4057qib7 1844 15 myelofibrosis myelofibrosis NN cord-005453-4057qib7 1844 16 between between IN cord-005453-4057qib7 1844 17 2003 2003 CD cord-005453-4057qib7 1844 18 and and CC cord-005453-4057qib7 1844 19 2018 2018 CD cord-005453-4057qib7 1844 20 at at IN cord-005453-4057qib7 1844 21 a a DT cord-005453-4057qib7 1844 22 single single JJ cord-005453-4057qib7 1844 23 large large JJ cord-005453-4057qib7 1844 24 academic academic JJ cord-005453-4057qib7 1844 25 medical medical JJ cord-005453-4057qib7 1844 26 center center NN cord-005453-4057qib7 1844 27 . . . cord-005453-4057qib7 1845 1 Patients patient NNS cord-005453-4057qib7 1845 2 ( ( -LRB- cord-005453-4057qib7 1845 3 n=59 n=59 NNP cord-005453-4057qib7 1845 4 ) ) -RRB- cord-005453-4057qib7 1845 5 were be VBD cord-005453-4057qib7 1845 6 treated treat VBN cord-005453-4057qib7 1845 7 with with IN cord-005453-4057qib7 1845 8 several several JJ cord-005453-4057qib7 1845 9 conditioning conditioning NN cord-005453-4057qib7 1845 10 regimens regimen NNS cord-005453-4057qib7 1845 11 that that WDT cord-005453-4057qib7 1845 12 were be VBD cord-005453-4057qib7 1845 13 grouped group VBN cord-005453-4057qib7 1845 14 according accord VBG cord-005453-4057qib7 1845 15 to to IN cord-005453-4057qib7 1845 16 conditioning conditioning NN cord-005453-4057qib7 1845 17 intensity intensity NN cord-005453-4057qib7 1845 18 . . . cord-005453-4057qib7 1846 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 1846 2 conditioning conditioning NN cord-005453-4057qib7 1846 3 ( ( -LRB- cord-005453-4057qib7 1846 4 MAC MAC NNP cord-005453-4057qib7 1846 5 ) ) -RRB- cord-005453-4057qib7 1846 6 included include VBD cord-005453-4057qib7 1846 7 busulfan busulfan NNP cord-005453-4057qib7 1846 8 12.8 12.8 CD cord-005453-4057qib7 1846 9 mg mg NNP cord-005453-4057qib7 1846 10 / / SYM cord-005453-4057qib7 1846 11 kg kg NNP cord-005453-4057qib7 1846 12 and and CC cord-005453-4057qib7 1846 13 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 1846 14 120 120 CD cord-005453-4057qib7 1846 15 mg mg NNP cord-005453-4057qib7 1846 16 / / SYM cord-005453-4057qib7 1846 17 kg kg NNP cord-005453-4057qib7 1847 1 ( ( -LRB- cord-005453-4057qib7 1847 2 BuCy BuCy NNP cord-005453-4057qib7 1847 3 , , , cord-005453-4057qib7 1847 4 n=10 n=10 NNP cord-005453-4057qib7 1847 5 ) ) -RRB- cord-005453-4057qib7 1847 6 , , , cord-005453-4057qib7 1847 7 fludarabine fludarabine NN cord-005453-4057qib7 1847 8 and and CC cord-005453-4057qib7 1847 9 busulfan busulfan NN cord-005453-4057qib7 1847 10 12.8 12.8 CD cord-005453-4057qib7 1847 11 mg mg NNP cord-005453-4057qib7 1847 12 / / SYM cord-005453-4057qib7 1847 13 kg kg NNP cord-005453-4057qib7 1847 14 ( ( -LRB- cord-005453-4057qib7 1847 15 Flu/ Flu/ NNP cord-005453-4057qib7 1847 16 Bu4 bu4 NN cord-005453-4057qib7 1847 17 , , , cord-005453-4057qib7 1847 18 n=9 n=9 NN cord-005453-4057qib7 1847 19 ) ) -RRB- cord-005453-4057qib7 1847 20 and and CC cord-005453-4057qib7 1847 21 fludarabine fludarabine NN cord-005453-4057qib7 1847 22 and and CC cord-005453-4057qib7 1847 23 treosulfan treosulfan NNP cord-005453-4057qib7 1847 24 30 30 CD cord-005453-4057qib7 1847 25 - - SYM cord-005453-4057qib7 1847 26 36 36 CD cord-005453-4057qib7 1847 27 g g NN cord-005453-4057qib7 1847 28 / / SYM cord-005453-4057qib7 1847 29 m m NN cord-005453-4057qib7 1847 30 2 2 CD cord-005453-4057qib7 1848 1 ( ( -LRB- cord-005453-4057qib7 1848 2 Flu/ Flu/ NNP cord-005453-4057qib7 1848 3 Treo Treo NNP cord-005453-4057qib7 1848 4 , , , cord-005453-4057qib7 1848 5 n=6 n=6 NN cord-005453-4057qib7 1848 6 ) ) -RRB- cord-005453-4057qib7 1848 7 . . . cord-005453-4057qib7 1849 1 Reduced reduce VBN cord-005453-4057qib7 1849 2 - - HYPH cord-005453-4057qib7 1849 3 intensity intensity NN cord-005453-4057qib7 1849 4 conditioning conditioning NN cord-005453-4057qib7 1849 5 included include VBD cord-005453-4057qib7 1849 6 fludarabine fludarabine NN cord-005453-4057qib7 1849 7 and and CC cord-005453-4057qib7 1849 8 busulfan busulfan NN cord-005453-4057qib7 1849 9 6.4 6.4 CD cord-005453-4057qib7 1849 10 - - HYPH cord-005453-4057qib7 1849 11 8.0 8.0 CD cord-005453-4057qib7 1849 12 mg mg NN cord-005453-4057qib7 1849 13 / / SYM cord-005453-4057qib7 1849 14 kg kg NNP cord-005453-4057qib7 1850 1 ( ( -LRB- cord-005453-4057qib7 1850 2 Flu flu NN cord-005453-4057qib7 1850 3 / / SYM cord-005453-4057qib7 1850 4 Bu2 bu2 NN cord-005453-4057qib7 1850 5 , , , cord-005453-4057qib7 1850 6 n=22 n=22 NNP cord-005453-4057qib7 1850 7 ) ) -RRB- cord-005453-4057qib7 1850 8 . . . cord-005453-4057qib7 1851 1 More more RBR cord-005453-4057qib7 1851 2 recently recently RB cord-005453-4057qib7 1851 3 we -PRON- PRP cord-005453-4057qib7 1851 4 adopted adopt VBD cord-005453-4057qib7 1851 5 the the DT cord-005453-4057qib7 1851 6 TBF tbf NN cord-005453-4057qib7 1851 7 regimen regimen NN cord-005453-4057qib7 1851 8 including include VBG cord-005453-4057qib7 1851 9 fludarabine fludarabine NN cord-005453-4057qib7 1851 10 , , , cord-005453-4057qib7 1851 11 busulfan busulfan NN cord-005453-4057qib7 1851 12 6.4 6.4 CD cord-005453-4057qib7 1851 13 - - HYPH cord-005453-4057qib7 1851 14 9.6 9.6 CD cord-005453-4057qib7 1851 15 mg mg NNP cord-005453-4057qib7 1851 16 / / SYM cord-005453-4057qib7 1851 17 kg kg NNP cord-005453-4057qib7 1851 18 and and CC cord-005453-4057qib7 1851 19 thiotepa thiotepa JJ cord-005453-4057qib7 1851 20 5 5 CD cord-005453-4057qib7 1851 21 - - SYM cord-005453-4057qib7 1851 22 10 10 CD cord-005453-4057qib7 1851 23 mg/ mg/ NN cord-005453-4057qib7 1851 24 m2 m2 NNP cord-005453-4057qib7 1851 25 ( ( -LRB- cord-005453-4057qib7 1851 26 n=12 n=12 NNP cord-005453-4057qib7 1851 27 ) ) -RRB- cord-005453-4057qib7 1851 28 . . . cord-005453-4057qib7 1852 1 All all DT cord-005453-4057qib7 1852 2 patients patient NNS cord-005453-4057qib7 1852 3 were be VBD cord-005453-4057qib7 1852 4 also also RB cord-005453-4057qib7 1852 5 given give VBN cord-005453-4057qib7 1852 6 anti anti JJ cord-005453-4057qib7 1852 7 - - JJ cord-005453-4057qib7 1852 8 thymocyte thymocyte JJ cord-005453-4057qib7 1852 9 globulin globulin NN cord-005453-4057qib7 1852 10 during during IN cord-005453-4057qib7 1852 11 conditioning conditioning NN cord-005453-4057qib7 1852 12 , , , cord-005453-4057qib7 1852 13 irrespective irrespective RB cord-005453-4057qib7 1852 14 of of IN cord-005453-4057qib7 1852 15 donor donor NN cord-005453-4057qib7 1852 16 source source NN cord-005453-4057qib7 1852 17 . . . cord-005453-4057qib7 1853 1 Results result NNS cord-005453-4057qib7 1853 2 : : : cord-005453-4057qib7 1854 1 The the DT cord-005453-4057qib7 1854 2 median median JJ cord-005453-4057qib7 1854 3 age age NN cord-005453-4057qib7 1854 4 was be VBD cord-005453-4057qib7 1854 5 59 59 CD cord-005453-4057qib7 1854 6 years year NNS cord-005453-4057qib7 1854 7 ( ( -LRB- cord-005453-4057qib7 1854 8 interquartile interquartile JJ cord-005453-4057qib7 1854 9 range range NN cord-005453-4057qib7 1854 10 [ [ -LRB- cord-005453-4057qib7 1854 11 IQR IQR NNP cord-005453-4057qib7 1854 12 ] ] -RRB- cord-005453-4057qib7 1855 1 52 52 CD cord-005453-4057qib7 1855 2 - - SYM cord-005453-4057qib7 1855 3 63 63 CD cord-005453-4057qib7 1855 4 ) ) -RRB- cord-005453-4057qib7 1855 5 . . . cord-005453-4057qib7 1856 1 The the DT cord-005453-4057qib7 1856 2 majority majority NN cord-005453-4057qib7 1856 3 of of IN cord-005453-4057qib7 1856 4 patients patient NNS cord-005453-4057qib7 1856 5 had have VBD cord-005453-4057qib7 1856 6 documented document VBN cord-005453-4057qib7 1856 7 splenomegaly splenomegaly NN cord-005453-4057qib7 1856 8 ( ( -LRB- cord-005453-4057qib7 1856 9 81 81 CD cord-005453-4057qib7 1856 10 % % NN cord-005453-4057qib7 1856 11 ) ) -RRB- cord-005453-4057qib7 1856 12 and and CC cord-005453-4057qib7 1856 13 were be VBD cord-005453-4057qib7 1856 14 not not RB cord-005453-4057qib7 1856 15 previously previously RB cord-005453-4057qib7 1856 16 exposed expose VBN cord-005453-4057qib7 1856 17 to to IN cord-005453-4057qib7 1856 18 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 1856 19 ( ( -LRB- cord-005453-4057qib7 1856 20 71 71 CD cord-005453-4057qib7 1856 21 % % NN cord-005453-4057qib7 1856 22 ) ) -RRB- cord-005453-4057qib7 1856 23 . . . cord-005453-4057qib7 1857 1 Donor donor NN cord-005453-4057qib7 1857 2 type type NN cord-005453-4057qib7 1857 3 was be VBD cord-005453-4057qib7 1857 4 an an DT cord-005453-4057qib7 1857 5 HLA HLA NNP cord-005453-4057qib7 1857 6 - - HYPH cord-005453-4057qib7 1857 7 matched match VBN cord-005453-4057qib7 1857 8 sibling sibling NN cord-005453-4057qib7 1857 9 ( ( -LRB- cord-005453-4057qib7 1857 10 41 41 CD cord-005453-4057qib7 1857 11 % % NN cord-005453-4057qib7 1857 12 ) ) -RRB- cord-005453-4057qib7 1857 13 , , , cord-005453-4057qib7 1857 14 10/10 10/10 CD cord-005453-4057qib7 1857 15 ( ( -LRB- cord-005453-4057qib7 1857 16 51 51 CD cord-005453-4057qib7 1857 17 % % NN cord-005453-4057qib7 1857 18 ) ) -RRB- cord-005453-4057qib7 1857 19 or or CC cord-005453-4057qib7 1857 20 9/10 9/10 CD cord-005453-4057qib7 1857 21 ( ( -LRB- cord-005453-4057qib7 1857 22 8 8 CD cord-005453-4057qib7 1857 23 % % NN cord-005453-4057qib7 1857 24 ) ) -RRB- cord-005453-4057qib7 1857 25 matched match VBN cord-005453-4057qib7 1857 26 unrelated unrelated JJ cord-005453-4057qib7 1857 27 donor donor NN cord-005453-4057qib7 1857 28 . . . cord-005453-4057qib7 1858 1 The the DT cord-005453-4057qib7 1858 2 DIPPS+ DIPPS+ NNP cord-005453-4057qib7 1858 3 score score NN cord-005453-4057qib7 1858 4 distribution distribution NN cord-005453-4057qib7 1858 5 was be VBD cord-005453-4057qib7 1858 6 intermediate-1 intermediate-1 NNP cord-005453-4057qib7 1858 7 ( ( -LRB- cord-005453-4057qib7 1858 8 16 16 CD cord-005453-4057qib7 1858 9 % % NN cord-005453-4057qib7 1858 10 ) ) -RRB- cord-005453-4057qib7 1858 11 , , , cord-005453-4057qib7 1858 12 intermediate-2 intermediate-2 NNP cord-005453-4057qib7 1858 13 ( ( -LRB- cord-005453-4057qib7 1858 14 45 45 CD cord-005453-4057qib7 1858 15 % % NN cord-005453-4057qib7 1858 16 ) ) -RRB- cord-005453-4057qib7 1858 17 , , , cord-005453-4057qib7 1858 18 or or CC cord-005453-4057qib7 1858 19 high high JJ cord-005453-4057qib7 1858 20 ( ( -LRB- cord-005453-4057qib7 1858 21 n=39 n=39 NNP cord-005453-4057qib7 1858 22 % % NN cord-005453-4057qib7 1858 23 ) ) -RRB- cord-005453-4057qib7 1858 24 . . . cord-005453-4057qib7 1859 1 The the DT cord-005453-4057qib7 1859 2 median median JJ cord-005453-4057qib7 1859 3 followup followup NN cord-005453-4057qib7 1859 4 was be VBD cord-005453-4057qib7 1859 5 3.2 3.2 CD cord-005453-4057qib7 1859 6 years year NNS cord-005453-4057qib7 1859 7 Since since IN cord-005453-4057qib7 1859 8 the the DT cord-005453-4057qib7 1859 9 success success NN cord-005453-4057qib7 1859 10 of of IN cord-005453-4057qib7 1859 11 tyrosine tyrosine NN cord-005453-4057qib7 1859 12 kinase kinase NN cord-005453-4057qib7 1859 13 inhibitors inhibitor NNS cord-005453-4057qib7 1859 14 ( ( -LRB- cord-005453-4057qib7 1859 15 TKIs TKIs NNP cord-005453-4057qib7 1859 16 ) ) -RRB- cord-005453-4057qib7 1859 17 , , , cord-005453-4057qib7 1859 18 transplant transplant NN cord-005453-4057qib7 1859 19 - - HYPH cord-005453-4057qib7 1859 20 related relate VBN cord-005453-4057qib7 1859 21 mortality mortality NN cord-005453-4057qib7 1859 22 is be VBZ cord-005453-4057qib7 1859 23 considered consider VBN cord-005453-4057qib7 1859 24 too too RB cord-005453-4057qib7 1859 25 high high JJ cord-005453-4057qib7 1859 26 to to TO cord-005453-4057qib7 1859 27 justify justify VB cord-005453-4057qib7 1859 28 allogeneic allogeneic IN cord-005453-4057qib7 1859 29 hematopoietic hematopoietic JJ cord-005453-4057qib7 1859 30 stem stem NN cord-005453-4057qib7 1859 31 cell cell NN cord-005453-4057qib7 1859 32 transplantation transplantation NN cord-005453-4057qib7 1859 33 ( ( -LRB- cord-005453-4057qib7 1859 34 alloHSCT alloHSCT NNP cord-005453-4057qib7 1859 35 ) ) -RRB- cord-005453-4057qib7 1859 36 as as IN cord-005453-4057qib7 1859 37 first first JJ cord-005453-4057qib7 1859 38 - - HYPH cord-005453-4057qib7 1859 39 line line NN cord-005453-4057qib7 1859 40 treatment treatment NN cord-005453-4057qib7 1859 41 for for IN cord-005453-4057qib7 1859 42 chronic chronic JJ cord-005453-4057qib7 1859 43 myeloid myeloid NN cord-005453-4057qib7 1859 44 leukemia leukemia NN cord-005453-4057qib7 1859 45 ( ( -LRB- cord-005453-4057qib7 1859 46 CML CML NNP cord-005453-4057qib7 1859 47 ) ) -RRB- cord-005453-4057qib7 1859 48 patients patient NNS cord-005453-4057qib7 1859 49 in in IN cord-005453-4057qib7 1859 50 chronic chronic JJ cord-005453-4057qib7 1859 51 phase phase NN cord-005453-4057qib7 1859 52 ( ( -LRB- cord-005453-4057qib7 1859 53 CP CP NNP cord-005453-4057qib7 1859 54 ) ) -RRB- cord-005453-4057qib7 1859 55 . . . cord-005453-4057qib7 1860 1 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 1860 2 is be VBZ cord-005453-4057qib7 1860 3 currently currently RB cord-005453-4057qib7 1860 4 considered consider VBN cord-005453-4057qib7 1860 5 for for IN cord-005453-4057qib7 1860 6 patients patient NNS cord-005453-4057qib7 1860 7 failing fail VBG cord-005453-4057qib7 1860 8 to to IN cord-005453-4057qib7 1860 9 at at RB cord-005453-4057qib7 1860 10 least least JJS cord-005453-4057qib7 1860 11 2 2 CD cord-005453-4057qib7 1860 12 TKIs tki NNS cord-005453-4057qib7 1860 13 or or CC cord-005453-4057qib7 1860 14 with with IN cord-005453-4057qib7 1860 15 disease disease NN cord-005453-4057qib7 1860 16 in in IN cord-005453-4057qib7 1860 17 advanced advanced JJ cord-005453-4057qib7 1860 18 phase phase NN cord-005453-4057qib7 1860 19 . . . cord-005453-4057qib7 1861 1 Nevertheless nevertheless RB cord-005453-4057qib7 1861 2 , , , cord-005453-4057qib7 1861 3 the the DT cord-005453-4057qib7 1861 4 optimal optimal JJ cord-005453-4057qib7 1861 5 timing timing NN cord-005453-4057qib7 1861 6 for for IN cord-005453-4057qib7 1861 7 transplant transplant NN cord-005453-4057qib7 1861 8 referral referral NN cord-005453-4057qib7 1861 9 is be VBZ cord-005453-4057qib7 1861 10 still still RB cord-005453-4057qib7 1861 11 not not RB cord-005453-4057qib7 1861 12 well well RB cord-005453-4057qib7 1861 13 defined define VBN cord-005453-4057qib7 1861 14 . . . cord-005453-4057qib7 1862 1 Methods method NNS cord-005453-4057qib7 1862 2 : : : cord-005453-4057qib7 1862 3 We -PRON- PRP cord-005453-4057qib7 1862 4 performed perform VBD cord-005453-4057qib7 1862 5 a a DT cord-005453-4057qib7 1862 6 retrospective retrospective JJ cord-005453-4057qib7 1862 7 analysis analysis NN cord-005453-4057qib7 1862 8 on on IN cord-005453-4057qib7 1862 9 23 23 CD cord-005453-4057qib7 1862 10 consecutive consecutive JJ cord-005453-4057qib7 1862 11 patients patient NNS cord-005453-4057qib7 1862 12 with with IN cord-005453-4057qib7 1862 13 CML CML NNP cord-005453-4057qib7 1862 14 in in IN cord-005453-4057qib7 1862 15 CP cp NN cord-005453-4057qib7 1862 16 receiving receive VBG cord-005453-4057qib7 1862 17 first first JJ cord-005453-4057qib7 1862 18 transplants transplant NNS cord-005453-4057qib7 1862 19 from from IN cord-005453-4057qib7 1862 20 an an DT cord-005453-4057qib7 1862 21 HLA HLA NNP cord-005453-4057qib7 1862 22 - - HYPH cord-005453-4057qib7 1862 23 identical identical JJ cord-005453-4057qib7 1862 24 sibling sibling NN cord-005453-4057qib7 1862 25 donor donor NN cord-005453-4057qib7 1862 26 with with IN cord-005453-4057qib7 1862 27 partially partially RB cord-005453-4057qib7 1862 28 T t NN cord-005453-4057qib7 1862 29 - - HYPH cord-005453-4057qib7 1862 30 cell cell NN cord-005453-4057qib7 1862 31 depleted deplete VBD cord-005453-4057qib7 1862 32 grafts graft NNS cord-005453-4057qib7 1862 33 from from IN cord-005453-4057qib7 1862 34 1998 1998 CD cord-005453-4057qib7 1862 35 to to IN cord-005453-4057qib7 1862 36 2016 2016 CD cord-005453-4057qib7 1862 37 at at IN cord-005453-4057qib7 1862 38 our -PRON- PRP$ cord-005453-4057qib7 1862 39 center center NN cord-005453-4057qib7 1862 40 . . . cord-005453-4057qib7 1863 1 Partial partial JJ cord-005453-4057qib7 1863 2 T t NN cord-005453-4057qib7 1863 3 - - HYPH cord-005453-4057qib7 1863 4 cell cell NN cord-005453-4057qib7 1863 5 depletion depletion NN cord-005453-4057qib7 1863 6 ( ( -LRB- cord-005453-4057qib7 1863 7 pTD pTD NNP cord-005453-4057qib7 1863 8 ) ) -RRB- cord-005453-4057qib7 1863 9 consisted consist VBN cord-005453-4057qib7 1863 10 of of IN cord-005453-4057qib7 1863 11 in in FW cord-005453-4057qib7 1863 12 vitro vitro FW cord-005453-4057qib7 1863 13 alemtuzumab alemtuzumab JJ cord-005453-4057qib7 1863 14 incubation incubation NN cord-005453-4057qib7 1863 15 of of IN cord-005453-4057qib7 1863 16 a a DT cord-005453-4057qib7 1863 17 part part NN cord-005453-4057qib7 1863 18 of of IN cord-005453-4057qib7 1863 19 the the DT cord-005453-4057qib7 1863 20 graft graft NN cord-005453-4057qib7 1863 21 for for IN cord-005453-4057qib7 1863 22 infusion infusion NN cord-005453-4057qib7 1863 23 at at IN cord-005453-4057qib7 1863 24 day day NN cord-005453-4057qib7 1863 25 0 0 NFP cord-005453-4057qib7 1863 26 while while IN cord-005453-4057qib7 1863 27 the the DT cord-005453-4057qib7 1863 28 rest rest NN cord-005453-4057qib7 1863 29 , , , cord-005453-4057qib7 1863 30 containing contain VBG cord-005453-4057qib7 1863 31 100x10 100x10 CD cord-005453-4057qib7 1863 32 6 6 CD cord-005453-4057qib7 1863 33 CD3 cd3 NN cord-005453-4057qib7 1864 1 + + CC cord-005453-4057qib7 1865 1 cells/ cells/ CD cord-005453-4057qib7 1866 1 kg kg NNP cord-005453-4057qib7 1866 2 was be VBD cord-005453-4057qib7 1866 3 given give VBN cord-005453-4057qib7 1866 4 as as IN cord-005453-4057qib7 1866 5 a a DT cord-005453-4057qib7 1866 6 T t NN cord-005453-4057qib7 1866 7 - - HYPH cord-005453-4057qib7 1866 8 cell cell NN cord-005453-4057qib7 1866 9 add add NN cord-005453-4057qib7 1866 10 - - HYPH cord-005453-4057qib7 1866 11 back back NN cord-005453-4057qib7 1866 12 at at IN cord-005453-4057qib7 1866 13 day day NN cord-005453-4057qib7 1866 14 1 1 CD cord-005453-4057qib7 1866 15 . . . cord-005453-4057qib7 1867 1 Donor donor NN cord-005453-4057qib7 1867 2 lymphocyte lymphocyte NN cord-005453-4057qib7 1867 3 infusions infusion NNS cord-005453-4057qib7 1867 4 ( ( -LRB- cord-005453-4057qib7 1867 5 DLIs dli NNS cord-005453-4057qib7 1867 6 ) ) -RRB- cord-005453-4057qib7 1867 7 were be VBD cord-005453-4057qib7 1867 8 provided provide VBN cord-005453-4057qib7 1867 9 , , , cord-005453-4057qib7 1867 10 in in IN cord-005453-4057qib7 1867 11 the the DT cord-005453-4057qib7 1867 12 absence absence NN cord-005453-4057qib7 1867 13 of of IN cord-005453-4057qib7 1867 14 GvHD GvHD NNP cord-005453-4057qib7 1867 15 , , , cord-005453-4057qib7 1867 16 in in IN cord-005453-4057qib7 1867 17 case case NN cord-005453-4057qib7 1867 18 of of IN cord-005453-4057qib7 1867 19 disease disease NN cord-005453-4057qib7 1867 20 relapse relapse NN cord-005453-4057qib7 1867 21 or or CC cord-005453-4057qib7 1867 22 mixed mixed JJ cord-005453-4057qib7 1867 23 chimerism chimerism NN cord-005453-4057qib7 1867 24 . . . cord-005453-4057qib7 1868 1 Molecular molecular JJ cord-005453-4057qib7 1868 2 monitoring monitoring NN cord-005453-4057qib7 1868 3 was be VBD cord-005453-4057qib7 1868 4 performed perform VBN cord-005453-4057qib7 1868 5 by by IN cord-005453-4057qib7 1868 6 3-month 3-month CD cord-005453-4057qib7 1868 7 BCR BCR NNP cord-005453-4057qib7 1868 8 - - HYPH cord-005453-4057qib7 1868 9 ABL1 ABL1 NNP cord-005453-4057qib7 1868 10 RT RT NNP cord-005453-4057qib7 1868 11 - - HYPH cord-005453-4057qib7 1868 12 qPCR qpcr NN cord-005453-4057qib7 1868 13 testing testing NN cord-005453-4057qib7 1868 14 in in IN cord-005453-4057qib7 1868 15 peripheral peripheral JJ cord-005453-4057qib7 1868 16 blood blood NN cord-005453-4057qib7 1868 17 during during IN cord-005453-4057qib7 1868 18 at at RB cord-005453-4057qib7 1868 19 least least JJS cord-005453-4057qib7 1868 20 a a DT cord-005453-4057qib7 1868 21 5-year 5-year CD cord-005453-4057qib7 1868 22 period period NN cord-005453-4057qib7 1868 23 after after IN cord-005453-4057qib7 1868 24 HSCT HSCT NNP cord-005453-4057qib7 1868 25 . . . cord-005453-4057qib7 1869 1 Thereafter thereafter RB cord-005453-4057qib7 1869 2 , , , cord-005453-4057qib7 1869 3 3-month 3-month CD cord-005453-4057qib7 1869 4 testing testing NN cord-005453-4057qib7 1869 5 schedule schedule NN cord-005453-4057qib7 1869 6 was be VBD cord-005453-4057qib7 1869 7 maintained maintain VBN cord-005453-4057qib7 1869 8 where where WRB cord-005453-4057qib7 1869 9 possible possible JJ cord-005453-4057qib7 1869 10 , , , cord-005453-4057qib7 1869 11 or or CC cord-005453-4057qib7 1869 12 followed follow VBN cord-005453-4057qib7 1869 13 by by IN cord-005453-4057qib7 1869 14 a a DT cord-005453-4057qib7 1869 15 6-month 6-month CD cord-005453-4057qib7 1869 16 one one CD cord-005453-4057qib7 1869 17 . . . cord-005453-4057qib7 1870 1 Kaplan Kaplan NNP cord-005453-4057qib7 1870 2 - - HYPH cord-005453-4057qib7 1870 3 Meier Meier NNP cord-005453-4057qib7 1870 4 method method NN cord-005453-4057qib7 1870 5 was be VBD cord-005453-4057qib7 1870 6 employed employ VBN cord-005453-4057qib7 1870 7 to to TO cord-005453-4057qib7 1870 8 determine determine VB cord-005453-4057qib7 1870 9 the the DT cord-005453-4057qib7 1870 10 probability probability NN cord-005453-4057qib7 1870 11 of of IN cord-005453-4057qib7 1870 12 overall overall JJ cord-005453-4057qib7 1870 13 survival survival NN cord-005453-4057qib7 1870 14 ( ( -LRB- cord-005453-4057qib7 1870 15 OS OS NNP cord-005453-4057qib7 1870 16 ) ) -RRB- cord-005453-4057qib7 1870 17 and and CC cord-005453-4057qib7 1870 18 leukemia leukemia NN cord-005453-4057qib7 1870 19 free free JJ cord-005453-4057qib7 1870 20 survival survival NN cord-005453-4057qib7 1870 21 ( ( -LRB- cord-005453-4057qib7 1870 22 LFS LFS NNP cord-005453-4057qib7 1870 23 ) ) -RRB- cord-005453-4057qib7 1870 24 since since IN cord-005453-4057qib7 1870 25 alloHSCT alloHSCT NNP cord-005453-4057qib7 1870 26 . . . cord-005453-4057qib7 1871 1 Results result NNS cord-005453-4057qib7 1871 2 : : : cord-005453-4057qib7 1872 1 Median median JJ cord-005453-4057qib7 1872 2 age age NN cord-005453-4057qib7 1872 3 at at IN cord-005453-4057qib7 1872 4 HSCT HSCT NNP cord-005453-4057qib7 1872 5 was be VBD cord-005453-4057qib7 1872 6 36 36 CD cord-005453-4057qib7 1872 7 years year NNS cord-005453-4057qib7 1872 8 ( ( -LRB- cord-005453-4057qib7 1872 9 range range NN cord-005453-4057qib7 1872 10 , , , cord-005453-4057qib7 1872 11 18 18 CD cord-005453-4057qib7 1872 12 - - SYM cord-005453-4057qib7 1872 13 58 58 CD cord-005453-4057qib7 1872 14 ) ) -RRB- cord-005453-4057qib7 1872 15 . . . cord-005453-4057qib7 1873 1 All all DT cord-005453-4057qib7 1873 2 patients patient NNS cord-005453-4057qib7 1873 3 were be VBD cord-005453-4057qib7 1873 4 in in IN cord-005453-4057qib7 1873 5 first first JJ cord-005453-4057qib7 1873 6 CP cp NN cord-005453-4057qib7 1873 7 but but CC cord-005453-4057qib7 1873 8 one one CD cord-005453-4057qib7 1873 9 who who WP cord-005453-4057qib7 1873 10 was be VBD cord-005453-4057qib7 1873 11 in in IN cord-005453-4057qib7 1873 12 second second JJ cord-005453-4057qib7 1873 13 CP cp NN cord-005453-4057qib7 1873 14 . . . cord-005453-4057qib7 1874 1 Twelve twelve CD cord-005453-4057qib7 1874 2 patients patient NNS cord-005453-4057qib7 1874 3 were be VBD cord-005453-4057qib7 1874 4 TKI TKI NNP cord-005453-4057qib7 1874 5 - - HYPH cord-005453-4057qib7 1874 6 naïve naïve JJ cord-005453-4057qib7 1874 7 at at IN cord-005453-4057qib7 1874 8 HSCT HSCT NNP cord-005453-4057qib7 1874 9 ( ( -LRB- cord-005453-4057qib7 1874 10 1998 1998 CD cord-005453-4057qib7 1874 11 HSCT HSCT NNP cord-005453-4057qib7 1874 12 ( ( -LRB- cord-005453-4057qib7 1875 1 -2001 -2001 NNP cord-005453-4057qib7 1875 2 , , , cord-005453-4057qib7 1875 3 4 4 CD cord-005453-4057qib7 1875 4 patients patient NNS cord-005453-4057qib7 1875 5 had have VBD cord-005453-4057qib7 1875 6 presented present VBN cord-005453-4057qib7 1875 7 suboptimal suboptimal JJ cord-005453-4057qib7 1875 8 response response NN cord-005453-4057qib7 1875 9 or/ or/ NN cord-005453-4057qib7 1875 10 and and CC cord-005453-4057qib7 1875 11 intolerance intolerance NN cord-005453-4057qib7 1875 12 to to IN cord-005453-4057qib7 1875 13 imatinib imatinib NN cord-005453-4057qib7 1875 14 ( ( -LRB- cord-005453-4057qib7 1875 15 2002 2002 CD cord-005453-4057qib7 1875 16 - - SYM cord-005453-4057qib7 1875 17 2004 2004 CD cord-005453-4057qib7 1875 18 period period NN cord-005453-4057qib7 1875 19 ) ) -RRB- cord-005453-4057qib7 1875 20 , , , cord-005453-4057qib7 1875 21 while while IN cord-005453-4057qib7 1875 22 the the DT cord-005453-4057qib7 1875 23 last last JJ cord-005453-4057qib7 1875 24 seven seven CD cord-005453-4057qib7 1875 25 patients patient NNS cord-005453-4057qib7 1875 26 had have VBD cord-005453-4057qib7 1875 27 presented present VBN cord-005453-4057qib7 1875 28 suboptimal suboptimal JJ cord-005453-4057qib7 1875 29 response response NN cord-005453-4057qib7 1875 30 or/ or/ NN cord-005453-4057qib7 1875 31 and and CC cord-005453-4057qib7 1875 32 intolerance intolerance NN cord-005453-4057qib7 1875 33 to to IN cord-005453-4057qib7 1875 34 imatinib imatinib NN cord-005453-4057qib7 1875 35 , , , cord-005453-4057qib7 1875 36 dasatinib dasatinib NN cord-005453-4057qib7 1875 37 and and CC cord-005453-4057qib7 1875 38 nilotinib nilotinib NN cord-005453-4057qib7 1875 39 ( ( -LRB- cord-005453-4057qib7 1875 40 2005 2005 CD cord-005453-4057qib7 1875 41 - - SYM cord-005453-4057qib7 1875 42 2016 2016 CD cord-005453-4057qib7 1875 43 period period NN cord-005453-4057qib7 1875 44 ) ) -RRB- cord-005453-4057qib7 1875 45 . . . cord-005453-4057qib7 1876 1 The the DT cord-005453-4057qib7 1876 2 time time NN cord-005453-4057qib7 1876 3 interval interval NN cord-005453-4057qib7 1876 4 from from IN cord-005453-4057qib7 1876 5 diagnosis diagnosis NN cord-005453-4057qib7 1876 6 to to IN cord-005453-4057qib7 1876 7 transplant transplant NN cord-005453-4057qib7 1876 8 was be VBD cord-005453-4057qib7 1876 9 < < NNP cord-005453-4057qib7 1876 10 12 12 CD cord-005453-4057qib7 1876 11 months month NNS cord-005453-4057qib7 1876 12 in in IN cord-005453-4057qib7 1876 13 11/23 11/23 CD cord-005453-4057qib7 1876 14 ( ( -LRB- cord-005453-4057qib7 1876 15 48 48 CD cord-005453-4057qib7 1876 16 % % NN cord-005453-4057qib7 1876 17 ) ) -RRB- cord-005453-4057qib7 1876 18 patients patient NNS cord-005453-4057qib7 1876 19 . . . cord-005453-4057qib7 1877 1 15 15 CD cord-005453-4057qib7 1877 2 ( ( -LRB- cord-005453-4057qib7 1877 3 65 65 CD cord-005453-4057qib7 1877 4 % % NN cord-005453-4057qib7 1877 5 ) ) -RRB- cord-005453-4057qib7 1877 6 patients patient NNS cord-005453-4057qib7 1877 7 had have VBD cord-005453-4057qib7 1877 8 an an DT cord-005453-4057qib7 1877 9 EBMT EBMT NNP cord-005453-4057qib7 1877 10 risk risk NN cord-005453-4057qib7 1877 11 score score NN cord-005453-4057qib7 1877 12 of of IN cord-005453-4057qib7 1877 13 0 0 CD cord-005453-4057qib7 1877 14 - - SYM cord-005453-4057qib7 1877 15 2 2 CD cord-005453-4057qib7 1877 16 , , , cord-005453-4057qib7 1877 17 while while IN cord-005453-4057qib7 1877 18 8 8 CD cord-005453-4057qib7 1877 19 ( ( -LRB- cord-005453-4057qib7 1877 20 35 35 CD cord-005453-4057qib7 1877 21 % % NN cord-005453-4057qib7 1877 22 ) ) -RRB- cord-005453-4057qib7 1877 23 patients patient NNS cord-005453-4057qib7 1877 24 of of IN cord-005453-4057qib7 1877 25 3 3 CD cord-005453-4057qib7 1877 26 - - SYM cord-005453-4057qib7 1877 27 4 4 CD cord-005453-4057qib7 1877 28 . . . cord-005453-4057qib7 1878 1 The the DT cord-005453-4057qib7 1878 2 conditioning conditioning NN cord-005453-4057qib7 1878 3 regimen regimen NN cord-005453-4057qib7 1878 4 was be VBD cord-005453-4057qib7 1878 5 myeloablative myeloablative JJ cord-005453-4057qib7 1878 6 for for IN cord-005453-4057qib7 1878 7 all all DT cord-005453-4057qib7 1878 8 but but IN cord-005453-4057qib7 1878 9 one one CD cord-005453-4057qib7 1878 10 patients patient NNS cord-005453-4057qib7 1878 11 . . . cord-005453-4057qib7 1879 1 The the DT cord-005453-4057qib7 1879 2 stem stem NN cord-005453-4057qib7 1879 3 cell cell NN cord-005453-4057qib7 1879 4 source source NN cord-005453-4057qib7 1879 5 was be VBD cord-005453-4057qib7 1879 6 PBSC PBSC NNP cord-005453-4057qib7 1879 7 for for IN cord-005453-4057qib7 1879 8 22 22 CD cord-005453-4057qib7 1879 9 patients patient NNS cord-005453-4057qib7 1879 10 and and CC cord-005453-4057qib7 1879 11 bone bone NN cord-005453-4057qib7 1879 12 marrow marrow NN cord-005453-4057qib7 1879 13 for for IN cord-005453-4057qib7 1879 14 one one CD cord-005453-4057qib7 1879 15 . . . cord-005453-4057qib7 1880 1 All all DT cord-005453-4057qib7 1880 2 patients patient NNS cord-005453-4057qib7 1880 3 engrafted engraft VBD cord-005453-4057qib7 1880 4 . . . cord-005453-4057qib7 1881 1 14 14 CD cord-005453-4057qib7 1881 2 patients patient NNS cord-005453-4057qib7 1881 3 presented present VBD cord-005453-4057qib7 1881 4 molecular molecular JJ cord-005453-4057qib7 1881 5 relapse relapse NN cord-005453-4057qib7 1881 6 and and CC cord-005453-4057qib7 1881 7 one one CD cord-005453-4057qib7 1881 8 patient patient JJ cord-005453-4057qib7 1881 9 hematological hematological JJ cord-005453-4057qib7 1881 10 relapse relapse NN cord-005453-4057qib7 1881 11 with with IN cord-005453-4057qib7 1881 12 a a DT cord-005453-4057qib7 1881 13 median median JJ cord-005453-4057qib7 1881 14 interval interval NN cord-005453-4057qib7 1881 15 from from IN cord-005453-4057qib7 1881 16 transplant transplant NN cord-005453-4057qib7 1881 17 to to IN cord-005453-4057qib7 1881 18 relapse relapse VB cord-005453-4057qib7 1881 19 of of IN cord-005453-4057qib7 1881 20 9 9 CD cord-005453-4057qib7 1881 21 months month NNS cord-005453-4057qib7 1881 22 ( ( -LRB- cord-005453-4057qib7 1881 23 range range NN cord-005453-4057qib7 1881 24 , , , cord-005453-4057qib7 1881 25 5 5 CD cord-005453-4057qib7 1881 26 - - SYM cord-005453-4057qib7 1881 27 70 70 CD cord-005453-4057qib7 1881 28 ) ) -RRB- cord-005453-4057qib7 1881 29 . . . cord-005453-4057qib7 1882 1 17 17 CD cord-005453-4057qib7 1882 2 patients patient NNS cord-005453-4057qib7 1882 3 received receive VBD cord-005453-4057qib7 1882 4 DLIs dli NNS cord-005453-4057qib7 1882 5 ( ( -LRB- cord-005453-4057qib7 1882 6 15 15 CD cord-005453-4057qib7 1882 7 for for IN cord-005453-4057qib7 1882 8 relapse relapse NN cord-005453-4057qib7 1882 9 and and CC cord-005453-4057qib7 1882 10 2 2 CD cord-005453-4057qib7 1882 11 for for IN cord-005453-4057qib7 1882 12 mixed mixed JJ cord-005453-4057qib7 1882 13 chimerism chimerism NN cord-005453-4057qib7 1882 14 ) ) -RRB- cord-005453-4057qib7 1882 15 , , , cord-005453-4057qib7 1882 16 while while IN cord-005453-4057qib7 1882 17 3 3 CD cord-005453-4057qib7 1882 18 patients patient NNS cord-005453-4057qib7 1882 19 in in IN cord-005453-4057qib7 1882 20 relapse relapse NN cord-005453-4057qib7 1882 21 also also RB cord-005453-4057qib7 1882 22 received receive VBD cord-005453-4057qib7 1882 23 TKI TKI NNP cord-005453-4057qib7 1882 24 . . . cord-005453-4057qib7 1883 1 Without without IN cord-005453-4057qib7 1883 2 prior prior JJ cord-005453-4057qib7 1883 3 administration administration NN cord-005453-4057qib7 1883 4 of of IN cord-005453-4057qib7 1883 5 DLI DLI NNP cord-005453-4057qib7 1883 6 , , , cord-005453-4057qib7 1883 7 3(13 3(13 CD cord-005453-4057qib7 1883 8 % % NN cord-005453-4057qib7 1883 9 ) ) -RRB- cord-005453-4057qib7 1883 10 patients patient NNS cord-005453-4057qib7 1883 11 presented present VBD cord-005453-4057qib7 1883 12 grade grade NN cord-005453-4057qib7 1883 13 II II NNP cord-005453-4057qib7 1883 14 aGvHD agvhd NN cord-005453-4057qib7 1883 15 and and CC cord-005453-4057qib7 1883 16 2 2 CD cord-005453-4057qib7 1883 17 patients patient NNS cord-005453-4057qib7 1883 18 moderate moderate JJ cord-005453-4057qib7 1883 19 cGvHD cgvhd NN cord-005453-4057qib7 1883 20 . . . cord-005453-4057qib7 1884 1 After after IN cord-005453-4057qib7 1884 2 DLI DLI NNP cord-005453-4057qib7 1884 3 , , , cord-005453-4057qib7 1884 4 aGvHD agvhd NN cord-005453-4057qib7 1884 5 occurred occur VBD cord-005453-4057qib7 1884 6 in in IN cord-005453-4057qib7 1884 7 3 3 CD cord-005453-4057qib7 1884 8 and and CC cord-005453-4057qib7 1884 9 cGvHD cgvhd NN cord-005453-4057qib7 1884 10 in in IN cord-005453-4057qib7 1884 11 4 4 CD cord-005453-4057qib7 1884 12 patients patient NNS cord-005453-4057qib7 1884 13 . . . cord-005453-4057qib7 1885 1 One one CD cord-005453-4057qib7 1885 2 patient patient NN cord-005453-4057qib7 1885 3 died die VBD cord-005453-4057qib7 1885 4 of of IN cord-005453-4057qib7 1885 5 disease disease NN cord-005453-4057qib7 1885 6 progression progression NN cord-005453-4057qib7 1885 7 3 3 CD cord-005453-4057qib7 1885 8 years year NNS cord-005453-4057qib7 1885 9 after after IN cord-005453-4057qib7 1885 10 HSCT HSCT NNP cord-005453-4057qib7 1885 11 and and CC cord-005453-4057qib7 1885 12 one one CD cord-005453-4057qib7 1885 13 of of IN cord-005453-4057qib7 1885 14 myocardial myocardial JJ cord-005453-4057qib7 1885 15 infarction infarction NN cord-005453-4057qib7 1885 16 19 19 CD cord-005453-4057qib7 1885 17 years year NNS cord-005453-4057qib7 1885 18 after after IN cord-005453-4057qib7 1885 19 HSCT HSCT NNP cord-005453-4057qib7 1885 20 . . . cord-005453-4057qib7 1886 1 With with IN cord-005453-4057qib7 1886 2 a a DT cord-005453-4057qib7 1886 3 median median JJ cord-005453-4057qib7 1886 4 follow follow NN cord-005453-4057qib7 1886 5 - - HYPH cord-005453-4057qib7 1886 6 up up NN cord-005453-4057qib7 1886 7 of of IN cord-005453-4057qib7 1886 8 14.4 14.4 CD cord-005453-4057qib7 1886 9 years year NNS cord-005453-4057qib7 1886 10 ( ( -LRB- cord-005453-4057qib7 1886 11 range range VBP cord-005453-4057qib7 1886 12 2.3 2.3 CD cord-005453-4057qib7 1886 13 - - HYPH cord-005453-4057qib7 1886 14 20.6 20.6 CD cord-005453-4057qib7 1886 15 ) ) -RRB- cord-005453-4057qib7 1886 16 , , , cord-005453-4057qib7 1886 17 15-year 15-year JJ cord-005453-4057qib7 1886 18 OS OS NNP cord-005453-4057qib7 1886 19 and and CC cord-005453-4057qib7 1886 20 LFS LFS NNP cord-005453-4057qib7 1886 21 were be VBD cord-005453-4057qib7 1886 22 95 95 CD cord-005453-4057qib7 1886 23 % % NN cord-005453-4057qib7 1886 24 . . . cord-005453-4057qib7 1887 1 At at IN cord-005453-4057qib7 1887 2 the the DT cord-005453-4057qib7 1887 3 time time NN cord-005453-4057qib7 1887 4 of of IN cord-005453-4057qib7 1887 5 the the DT cord-005453-4057qib7 1887 6 analysis analysis NN cord-005453-4057qib7 1887 7 21/23 21/23 CD cord-005453-4057qib7 1887 8 patients patient NNS cord-005453-4057qib7 1887 9 were be VBD cord-005453-4057qib7 1887 10 alive alive JJ cord-005453-4057qib7 1887 11 and and CC cord-005453-4057qib7 1887 12 in in IN cord-005453-4057qib7 1887 13 major major JJ cord-005453-4057qib7 1887 14 molecular molecular JJ cord-005453-4057qib7 1887 15 response response NN cord-005453-4057qib7 1887 16 . . . cord-005453-4057qib7 1888 1 Conclusions conclusion NNS cord-005453-4057qib7 1888 2 : : : cord-005453-4057qib7 1889 1 These these DT cord-005453-4057qib7 1889 2 results result NNS cord-005453-4057qib7 1889 3 of of IN cord-005453-4057qib7 1889 4 excellent excellent JJ cord-005453-4057qib7 1889 5 long long JJ cord-005453-4057qib7 1889 6 - - HYPH cord-005453-4057qib7 1889 7 term term NN cord-005453-4057qib7 1889 8 survival survival NN cord-005453-4057qib7 1889 9 and and CC cord-005453-4057qib7 1889 10 no no DT cord-005453-4057qib7 1889 11 transplant transplant NN cord-005453-4057qib7 1889 12 - - HYPH cord-005453-4057qib7 1889 13 related relate VBN cord-005453-4057qib7 1889 14 mortality mortality NN cord-005453-4057qib7 1889 15 suggest suggest VBP cord-005453-4057qib7 1889 16 that that IN cord-005453-4057qib7 1889 17 pTCD ptcd NN cord-005453-4057qib7 1889 18 improves improve VBZ cord-005453-4057qib7 1889 19 the the DT cord-005453-4057qib7 1889 20 outcome outcome NN cord-005453-4057qib7 1889 21 of of IN cord-005453-4057qib7 1889 22 CP CP NNP cord-005453-4057qib7 1889 23 - - HYPH cord-005453-4057qib7 1889 24 CML CML NNP cord-005453-4057qib7 1889 25 patients patient NNS cord-005453-4057qib7 1889 26 transplanted transplant VBN cord-005453-4057qib7 1889 27 from from IN cord-005453-4057qib7 1889 28 an an DT cord-005453-4057qib7 1889 29 identical identical JJ cord-005453-4057qib7 1889 30 sibling sibling NN cord-005453-4057qib7 1889 31 donor donor NN cord-005453-4057qib7 1889 32 and and CC cord-005453-4057qib7 1889 33 they -PRON- PRP cord-005453-4057qib7 1889 34 can can MD cord-005453-4057qib7 1889 35 be be VB cord-005453-4057qib7 1889 36 useful useful JJ cord-005453-4057qib7 1889 37 for for IN cord-005453-4057qib7 1889 38 deciding decide VBG cord-005453-4057qib7 1889 39 risk risk NN cord-005453-4057qib7 1889 40 - - HYPH cord-005453-4057qib7 1889 41 adapted adapt VBN cord-005453-4057qib7 1889 42 strategies strategy NNS cord-005453-4057qib7 1889 43 . . . cord-005453-4057qib7 1890 1 We -PRON- PRP cord-005453-4057qib7 1890 2 believe believe VBP cord-005453-4057qib7 1890 3 that that IN cord-005453-4057qib7 1890 4 pTCD ptcd NN cord-005453-4057qib7 1890 5 could could MD cord-005453-4057qib7 1890 6 allow allow VB cord-005453-4057qib7 1890 7 earlier early JJR cord-005453-4057qib7 1890 8 transplant transplant NN cord-005453-4057qib7 1890 9 referral referral NN cord-005453-4057qib7 1890 10 of of IN cord-005453-4057qib7 1890 11 patients patient NNS cord-005453-4057qib7 1890 12 failing fail VBG cord-005453-4057qib7 1890 13 TKIs tki NNS cord-005453-4057qib7 1890 14 and and CC cord-005453-4057qib7 1890 15 having have VBG cord-005453-4057qib7 1890 16 an an DT cord-005453-4057qib7 1890 17 identical identical JJ cord-005453-4057qib7 1890 18 sibling sibling NN cord-005453-4057qib7 1890 19 donor donor NN cord-005453-4057qib7 1890 20 . . . cord-005453-4057qib7 1891 1 Disclosure disclosure NN cord-005453-4057qib7 1891 2 : : : cord-005453-4057qib7 1891 3 Nothing nothing NN cord-005453-4057qib7 1891 4 to to TO cord-005453-4057qib7 1891 5 declare declare VB cord-005453-4057qib7 1891 6 Single single JJ cord-005453-4057qib7 1891 7 tertiary tertiary JJ cord-005453-4057qib7 1891 8 centre centre NN cord-005453-4057qib7 1891 9 experience experience NN cord-005453-4057qib7 1891 10 in in IN cord-005453-4057qib7 1891 11 allogeneic allogeneic JJ cord-005453-4057qib7 1891 12 haematopoietic haematopoietic JJ cord-005453-4057qib7 1891 13 stem stem NN cord-005453-4057qib7 1891 14 cell cell NN cord-005453-4057qib7 1891 15 transplantation transplantation NN cord-005453-4057qib7 1891 16 ( ( -LRB- cord-005453-4057qib7 1891 17 allo allo NN cord-005453-4057qib7 1891 18 - - HYPH cord-005453-4057qib7 1891 19 HSCT HSCT NNP cord-005453-4057qib7 1891 20 ) ) -RRB- cord-005453-4057qib7 1891 21 for for IN cord-005453-4057qib7 1891 22 primary primary JJ cord-005453-4057qib7 1891 23 and and CC cord-005453-4057qib7 1891 24 secondary secondary JJ cord-005453-4057qib7 1891 25 myelofibrosis myelofibrosis NN cord-005453-4057qib7 1891 26 ( ( -LRB- cord-005453-4057qib7 1891 27 MF MF NNP cord-005453-4057qib7 1891 28 ) ) -RRB- cord-005453-4057qib7 1892 1 The the DT cord-005453-4057qib7 1892 2 only only JJ cord-005453-4057qib7 1892 3 curative curative JJ cord-005453-4057qib7 1892 4 option option NN cord-005453-4057qib7 1892 5 for for IN cord-005453-4057qib7 1892 6 fit fit JJ cord-005453-4057qib7 1892 7 patients patient NNS cord-005453-4057qib7 1892 8 is be VBZ cord-005453-4057qib7 1892 9 allo allo NN cord-005453-4057qib7 1892 10 - - HYPH cord-005453-4057qib7 1892 11 HSCT HSCT NNP cord-005453-4057qib7 1892 12 . . . cord-005453-4057qib7 1893 1 Novel novel NN cord-005453-4057qib7 1893 2 therapy therapy NN cord-005453-4057qib7 1893 3 is be VBZ cord-005453-4057qib7 1893 4 emerging emerge VBG cord-005453-4057qib7 1893 5 but but CC cord-005453-4057qib7 1893 6 current current JJ cord-005453-4057qib7 1893 7 recommendation recommendation NN cord-005453-4057qib7 1893 8 is be VBZ cord-005453-4057qib7 1893 9 that that IN cord-005453-4057qib7 1893 10 eligible eligible JJ cord-005453-4057qib7 1893 11 patients patient NNS cord-005453-4057qib7 1893 12 with with IN cord-005453-4057qib7 1893 13 life life NN cord-005453-4057qib7 1893 14 expectancy expectancy NN cord-005453-4057qib7 1893 15 less less JJR cord-005453-4057qib7 1893 16 than than IN cord-005453-4057qib7 1893 17 5 5 CD cord-005453-4057qib7 1893 18 years year NNS cord-005453-4057qib7 1893 19 should should MD cord-005453-4057qib7 1893 20 be be VB cord-005453-4057qib7 1893 21 considered consider VBN cord-005453-4057qib7 1893 22 for for IN cord-005453-4057qib7 1893 23 allografting allografte VBG cord-005453-4057qib7 1893 24 . . . cord-005453-4057qib7 1894 1 Methods method NNS cord-005453-4057qib7 1894 2 : : : cord-005453-4057qib7 1894 3 We -PRON- PRP cord-005453-4057qib7 1894 4 retrospectively retrospectively RB cord-005453-4057qib7 1894 5 looked look VBD cord-005453-4057qib7 1894 6 at at IN cord-005453-4057qib7 1894 7 the the DT cord-005453-4057qib7 1894 8 clinical clinical JJ cord-005453-4057qib7 1894 9 features feature NNS cord-005453-4057qib7 1894 10 and and CC cord-005453-4057qib7 1894 11 outcomes outcome NNS cord-005453-4057qib7 1894 12 of of IN cord-005453-4057qib7 1894 13 all all DT cord-005453-4057qib7 1894 14 allo allo NN cord-005453-4057qib7 1894 15 - - HYPH cord-005453-4057qib7 1894 16 HSCT HSCT NNP cord-005453-4057qib7 1894 17 for for IN cord-005453-4057qib7 1894 18 MF MF NNP cord-005453-4057qib7 1894 19 performed perform VBN cord-005453-4057qib7 1894 20 in in IN cord-005453-4057qib7 1894 21 our -PRON- PRP$ cord-005453-4057qib7 1894 22 centre centre NN cord-005453-4057qib7 1894 23 since since IN cord-005453-4057qib7 1894 24 2010 2010 CD cord-005453-4057qib7 1894 25 . . . cord-005453-4057qib7 1895 1 Results result NNS cord-005453-4057qib7 1895 2 : : : cord-005453-4057qib7 1895 3 12 12 CD cord-005453-4057qib7 1895 4 patients patient NNS cord-005453-4057qib7 1895 5 ( ( -LRB- cord-005453-4057qib7 1895 6 10 10 CD cord-005453-4057qib7 1895 7 male male NN cord-005453-4057qib7 1895 8 , , , cord-005453-4057qib7 1895 9 2 2 CD cord-005453-4057qib7 1895 10 female female JJ cord-005453-4057qib7 1895 11 ) ) -RRB- cord-005453-4057qib7 1895 12 aged age VBN cord-005453-4057qib7 1895 13 between between IN cord-005453-4057qib7 1895 14 29 29 CD cord-005453-4057qib7 1895 15 - - SYM cord-005453-4057qib7 1895 16 68 68 CD cord-005453-4057qib7 1895 17 years year NNS cord-005453-4057qib7 1895 18 old old JJ cord-005453-4057qib7 1895 19 ( ( -LRB- cord-005453-4057qib7 1895 20 median median JJ cord-005453-4057qib7 1895 21 age age NN cord-005453-4057qib7 1895 22 60 60 CD cord-005453-4057qib7 1895 23 ) ) -RRB- cord-005453-4057qib7 1895 24 with with IN cord-005453-4057qib7 1895 25 intermediate-2 intermediate-2 NNP cord-005453-4057qib7 1895 26 or or CC cord-005453-4057qib7 1895 27 high high JJ cord-005453-4057qib7 1895 28 - - HYPH cord-005453-4057qib7 1895 29 risk risk NN cord-005453-4057qib7 1895 30 MF mf NN cord-005453-4057qib7 1895 31 as as IN cord-005453-4057qib7 1895 32 per per IN cord-005453-4057qib7 1895 33 the the DT cord-005453-4057qib7 1895 34 International International NNP cord-005453-4057qib7 1895 35 Prognostic Prognostic NNP cord-005453-4057qib7 1895 36 Scoring Scoring NNP cord-005453-4057qib7 1895 37 System System NNP cord-005453-4057qib7 1895 38 ( ( -LRB- cord-005453-4057qib7 1895 39 IPSS IPSS NNP cord-005453-4057qib7 1895 40 ) ) -RRB- cord-005453-4057qib7 1895 41 or or CC cord-005453-4057qib7 1895 42 Dynamic dynamic JJ cord-005453-4057qib7 1895 43 IPPS IPPS NNPS cord-005453-4057qib7 1895 44 ( ( -LRB- cord-005453-4057qib7 1895 45 DIPPS DIPPS NNP cord-005453-4057qib7 1895 46 ) ) -RRB- cord-005453-4057qib7 1895 47 were be VBD cord-005453-4057qib7 1895 48 transplanted transplant VBN cord-005453-4057qib7 1895 49 in in IN cord-005453-4057qib7 1895 50 our -PRON- PRP$ cord-005453-4057qib7 1895 51 centre centre NN cord-005453-4057qib7 1895 52 since since IN cord-005453-4057qib7 1895 53 2010 2010 CD cord-005453-4057qib7 1895 54 . . . cord-005453-4057qib7 1896 1 6 6 CD cord-005453-4057qib7 1896 2 of of IN cord-005453-4057qib7 1896 3 them -PRON- PRP cord-005453-4057qib7 1896 4 ( ( -LRB- cord-005453-4057qib7 1896 5 50 50 CD cord-005453-4057qib7 1896 6 % % NN cord-005453-4057qib7 1896 7 ) ) -RRB- cord-005453-4057qib7 1896 8 were be VBD cord-005453-4057qib7 1896 9 diagnosed diagnose VBN cord-005453-4057qib7 1896 10 with with IN cord-005453-4057qib7 1896 11 PMF PMF NNP cord-005453-4057qib7 1896 12 and and CC cord-005453-4057qib7 1896 13 the the DT cord-005453-4057qib7 1896 14 remaining remain VBG cord-005453-4057qib7 1896 15 50 50 CD cord-005453-4057qib7 1896 16 % % NN cord-005453-4057qib7 1896 17 with with IN cord-005453-4057qib7 1896 18 secondary secondary JJ cord-005453-4057qib7 1896 19 MF MF NNP cord-005453-4057qib7 1896 20 ; ; : cord-005453-4057qib7 1896 21 4 4 CD cord-005453-4057qib7 1896 22 post post VB cord-005453-4057qib7 1896 23 - - NN cord-005453-4057qib7 1896 24 ET et NN cord-005453-4057qib7 1896 25 and and CC cord-005453-4057qib7 1896 26 2 2 CD cord-005453-4057qib7 1896 27 post post JJ cord-005453-4057qib7 1896 28 - - JJ cord-005453-4057qib7 1896 29 PV PV NNP cord-005453-4057qib7 1896 30 MF MF NNP cord-005453-4057qib7 1896 31 . . . cord-005453-4057qib7 1897 1 2/12 2/12 CD cord-005453-4057qib7 1897 2 of of IN cord-005453-4057qib7 1897 3 our -PRON- PRP$ cord-005453-4057qib7 1897 4 patient patient NN cord-005453-4057qib7 1897 5 group group NN cord-005453-4057qib7 1897 6 received receive VBD cord-005453-4057qib7 1897 7 a a DT cord-005453-4057qib7 1897 8 sibling sibling NN cord-005453-4057qib7 1897 9 allograft allograft NN cord-005453-4057qib7 1897 10 and and CC cord-005453-4057qib7 1897 11 10/12 10/12 CD cord-005453-4057qib7 1897 12 a a DT cord-005453-4057qib7 1897 13 matched match VBN cord-005453-4057qib7 1897 14 unrelated unrelated JJ cord-005453-4057qib7 1897 15 donor donor NN cord-005453-4057qib7 1897 16 allograft allograft NN cord-005453-4057qib7 1897 17 ( ( -LRB- cord-005453-4057qib7 1897 18 70 70 CD cord-005453-4057qib7 1897 19 % % NN cord-005453-4057qib7 1897 20 received receive VBD cord-005453-4057qib7 1897 21 a a DT cord-005453-4057qib7 1897 22 10/10 10/10 CD cord-005453-4057qib7 1897 23 Human Human NNP cord-005453-4057qib7 1897 24 Leukocyte Leukocyte NNP cord-005453-4057qib7 1897 25 Antigen Antigen NNP cord-005453-4057qib7 1897 26 ( ( -LRB- cord-005453-4057qib7 1897 27 HLA)-matched hla)-matched CD cord-005453-4057qib7 1897 28 transplant transplant NN cord-005453-4057qib7 1897 29 , , , cord-005453-4057qib7 1897 30 20 20 CD cord-005453-4057qib7 1897 31 % % NN cord-005453-4057qib7 1897 32 a a DT cord-005453-4057qib7 1897 33 9/10 9/10 CD cord-005453-4057qib7 1897 34 HLAmatched hlamatched NN cord-005453-4057qib7 1897 35 and and CC cord-005453-4057qib7 1897 36 10 10 CD cord-005453-4057qib7 1897 37 % % NN cord-005453-4057qib7 1897 38 a a DT cord-005453-4057qib7 1897 39 8/10 8/10 CD cord-005453-4057qib7 1897 40 HLA HLA NNP cord-005453-4057qib7 1897 41 - - HYPH cord-005453-4057qib7 1897 42 matched match VBN cord-005453-4057qib7 1897 43 graft graft NN cord-005453-4057qib7 1897 44 ) ) -RRB- cord-005453-4057qib7 1897 45 . . . cord-005453-4057qib7 1898 1 All all DT cord-005453-4057qib7 1898 2 patients patient NNS cord-005453-4057qib7 1898 3 received receive VBD cord-005453-4057qib7 1898 4 a a DT cord-005453-4057qib7 1898 5 reduced reduce VBN cord-005453-4057qib7 1898 6 intensity intensity NN cord-005453-4057qib7 1898 7 conditioning conditioning NN cord-005453-4057qib7 1898 8 ( ( -LRB- cord-005453-4057qib7 1898 9 RIC RIC NNP cord-005453-4057qib7 1898 10 ) ) -RRB- cord-005453-4057qib7 1898 11 ; ; : cord-005453-4057qib7 1898 12 3/12 3/12 CD cord-005453-4057qib7 1898 13 patients patient NNS cord-005453-4057qib7 1898 14 with with IN cord-005453-4057qib7 1898 15 Fludarabine/ fludarabine/ CD cord-005453-4057qib7 1898 16 Melphalan/ Melphalan/ NNP cord-005453-4057qib7 1898 17 Campath Campath NNP cord-005453-4057qib7 1898 18 ( ( -LRB- cord-005453-4057qib7 1898 19 FMC FMC NNP cord-005453-4057qib7 1898 20 ) ) -RRB- cord-005453-4057qib7 1898 21 , , , cord-005453-4057qib7 1898 22 8/ 8/ CD cord-005453-4057qib7 1898 23 12 12 CD cord-005453-4057qib7 1898 24 Fludarabine/ fludarabine/ CD cord-005453-4057qib7 1899 1 Busulphan/ busulphan/ IN cord-005453-4057qib7 1899 2 ATG ATG NNP cord-005453-4057qib7 1899 3 ( ( -LRB- cord-005453-4057qib7 1899 4 FBATG FBATG NNP cord-005453-4057qib7 1899 5 ) ) -RRB- cord-005453-4057qib7 1899 6 and and CC cord-005453-4057qib7 1899 7 1 1 CD cord-005453-4057qib7 1899 8 Fludarabine/ Fludarabine/ NNP cord-005453-4057qib7 1899 9 Ara Ara NNP cord-005453-4057qib7 1899 10 - - HYPH cord-005453-4057qib7 1899 11 C/ C/ NNP cord-005453-4057qib7 1899 12 Campath Campath NNP cord-005453-4057qib7 1899 13 ( ( -LRB- cord-005453-4057qib7 1899 14 FLAG/ FLAG/ NNP cord-005453-4057qib7 1899 15 Campath Campath NNP cord-005453-4057qib7 1899 16 ) ) -RRB- cord-005453-4057qib7 1900 1 ; ; : cord-005453-4057qib7 1900 2 all all DT cord-005453-4057qib7 1900 3 received receive VBD cord-005453-4057qib7 1900 4 peripheral peripheral JJ cord-005453-4057qib7 1900 5 blood blood NN cord-005453-4057qib7 1900 6 as as IN cord-005453-4057qib7 1900 7 source source NN cord-005453-4057qib7 1900 8 of of IN cord-005453-4057qib7 1900 9 HSC HSC NNP cord-005453-4057qib7 1900 10 . . . cord-005453-4057qib7 1901 1 Engraftment Engraftment NNP cord-005453-4057qib7 1901 2 occurred occur VBD cord-005453-4057qib7 1901 3 between between IN cord-005453-4057qib7 1901 4 day day NN cord-005453-4057qib7 1901 5 13 13 CD cord-005453-4057qib7 1901 6 - - SYM cord-005453-4057qib7 1901 7 48 48 CD cord-005453-4057qib7 1901 8 , , , cord-005453-4057qib7 1901 9 with with IN cord-005453-4057qib7 1901 10 a a DT cord-005453-4057qib7 1901 11 median median NN cord-005453-4057qib7 1901 12 of of IN cord-005453-4057qib7 1901 13 D+17 D+17 NNP cord-005453-4057qib7 1901 14 . . . cord-005453-4057qib7 1902 1 One one CD cord-005453-4057qib7 1902 2 late late JJ cord-005453-4057qib7 1902 3 graft graft NN cord-005453-4057qib7 1902 4 rejection rejection NN cord-005453-4057qib7 1902 5 occurred occur VBD cord-005453-4057qib7 1902 6 . . . cord-005453-4057qib7 1903 1 All all DT cord-005453-4057qib7 1903 2 patients patient NNS cord-005453-4057qib7 1903 3 were be VBD cord-005453-4057qib7 1903 4 alive alive JJ cord-005453-4057qib7 1903 5 at at IN cord-005453-4057qib7 1903 6 D+100 D+100 NNS cord-005453-4057qib7 1903 7 . . . cord-005453-4057qib7 1904 1 9 9 CD cord-005453-4057qib7 1904 2 patients patient NNS cord-005453-4057qib7 1904 3 are be VBP cord-005453-4057qib7 1904 4 currently currently RB cord-005453-4057qib7 1904 5 alive alive JJ cord-005453-4057qib7 1904 6 ; ; : cord-005453-4057qib7 1904 7 Overall overall JJ cord-005453-4057qib7 1904 8 survival survival NN cord-005453-4057qib7 1904 9 ( ( -LRB- cord-005453-4057qib7 1904 10 OS OS NNP cord-005453-4057qib7 1904 11 ) ) -RRB- cord-005453-4057qib7 1904 12 is be VBZ cord-005453-4057qib7 1904 13 75 75 CD cord-005453-4057qib7 1904 14 % % NN cord-005453-4057qib7 1904 15 . . . cord-005453-4057qib7 1905 1 Transplant transplant NN cord-005453-4057qib7 1905 2 related relate VBN cord-005453-4057qib7 1905 3 mortality mortality NN cord-005453-4057qib7 1905 4 ( ( -LRB- cord-005453-4057qib7 1905 5 TRM TRM NNP cord-005453-4057qib7 1905 6 ) ) -RRB- cord-005453-4057qib7 1905 7 was be VBD cord-005453-4057qib7 1905 8 16.6 16.6 CD cord-005453-4057qib7 1905 9 % % NN cord-005453-4057qib7 1905 10 at at IN cord-005453-4057qib7 1905 11 1 1 CD cord-005453-4057qib7 1905 12 year year NN cord-005453-4057qib7 1905 13 , , , cord-005453-4057qib7 1905 14 25 25 CD cord-005453-4057qib7 1905 15 % % NN cord-005453-4057qib7 1905 16 at at IN cord-005453-4057qib7 1905 17 3 3 CD cord-005453-4057qib7 1905 18 years year NNS cord-005453-4057qib7 1905 19 . . . cord-005453-4057qib7 1906 1 1 1 CD cord-005453-4057qib7 1906 2 patient patient NN cord-005453-4057qib7 1906 3 died die VBD cord-005453-4057qib7 1906 4 of of IN cord-005453-4057qib7 1906 5 graft graft NN cord-005453-4057qib7 1906 6 versus versus IN cord-005453-4057qib7 1906 7 host host NN cord-005453-4057qib7 1906 8 disease disease NN cord-005453-4057qib7 1906 9 ( ( -LRB- cord-005453-4057qib7 1906 10 GvHD GvHD NNP cord-005453-4057qib7 1906 11 ) ) -RRB- cord-005453-4057qib7 1906 12 and and CC cord-005453-4057qib7 1906 13 2 2 CD cord-005453-4057qib7 1906 14 patients patient NNS cord-005453-4057qib7 1906 15 of of IN cord-005453-4057qib7 1906 16 septicaemia septicaemia NN cord-005453-4057qib7 1906 17 leading lead VBG cord-005453-4057qib7 1906 18 to to IN cord-005453-4057qib7 1906 19 multiorgan multiorgan NNP cord-005453-4057qib7 1906 20 failure failure NN cord-005453-4057qib7 1906 21 . . . cord-005453-4057qib7 1907 1 Acute acute JJ cord-005453-4057qib7 1907 2 GvHD GvHD NNP cord-005453-4057qib7 1907 3 grade grade NN cord-005453-4057qib7 1907 4 II ii CD cord-005453-4057qib7 1907 5 skin skin NN cord-005453-4057qib7 1907 6 occurred occur VBD cord-005453-4057qib7 1907 7 in in IN cord-005453-4057qib7 1907 8 5 5 CD cord-005453-4057qib7 1907 9 patients patient NNS cord-005453-4057qib7 1907 10 , , , cord-005453-4057qib7 1907 11 grade grade NN cord-005453-4057qib7 1907 12 III III NNP cord-005453-4057qib7 1907 13 and and CC cord-005453-4057qib7 1907 14 above above RB cord-005453-4057qib7 1907 15 in in IN cord-005453-4057qib7 1907 16 2 2 CD cord-005453-4057qib7 1907 17 patients patient NNS cord-005453-4057qib7 1907 18 . . . cord-005453-4057qib7 1908 1 5 5 CD cord-005453-4057qib7 1908 2 patients patient NNS cord-005453-4057qib7 1908 3 have have VBP cord-005453-4057qib7 1908 4 limited limit VBN cord-005453-4057qib7 1908 5 chronic chronic JJ cord-005453-4057qib7 1908 6 GvHD GvHD NNP cord-005453-4057qib7 1908 7 . . . cord-005453-4057qib7 1909 1 2/12 2/12 CD cord-005453-4057qib7 1909 2 patients patient NNS cord-005453-4057qib7 1909 3 received receive VBD cord-005453-4057qib7 1909 4 Donor Donor NNP cord-005453-4057qib7 1909 5 Lymphocyte Lymphocyte NNP cord-005453-4057qib7 1909 6 Infusion Infusion NNP cord-005453-4057qib7 1909 7 ( ( -LRB- cord-005453-4057qib7 1909 8 DLI DLI NNP cord-005453-4057qib7 1909 9 ) ) -RRB- cord-005453-4057qib7 1909 10 for for IN cord-005453-4057qib7 1909 11 mixed mixed JJ cord-005453-4057qib7 1909 12 chimerism chimerism NN cord-005453-4057qib7 1909 13 ( ( -LRB- cord-005453-4057qib7 1909 14 one one CD cord-005453-4057qib7 1909 15 of of IN cord-005453-4057qib7 1909 16 which which WDT cord-005453-4057qib7 1909 17 had have VBD cord-005453-4057qib7 1909 18 2nd 2nd JJ cord-005453-4057qib7 1909 19 graft graft NN cord-005453-4057qib7 1909 20 failure failure NN cord-005453-4057qib7 1909 21 ) ) -RRB- cord-005453-4057qib7 1909 22 . . . cord-005453-4057qib7 1910 1 Out out IN cord-005453-4057qib7 1910 2 of of IN cord-005453-4057qib7 1910 3 these these DT cord-005453-4057qib7 1910 4 2 2 CD cord-005453-4057qib7 1910 5 patients patient NNS cord-005453-4057qib7 1910 6 1 1 CD cord-005453-4057qib7 1910 7 developed develop VBD cord-005453-4057qib7 1910 8 acute acute JJ cord-005453-4057qib7 1910 9 grade grade NN cord-005453-4057qib7 1910 10 4 4 CD cord-005453-4057qib7 1910 11 GvHD gvhd NN cord-005453-4057qib7 1910 12 and and CC cord-005453-4057qib7 1910 13 died die VBD cord-005453-4057qib7 1910 14 . . . cord-005453-4057qib7 1911 1 Response response NN cord-005453-4057qib7 1911 2 rate rate NN cord-005453-4057qib7 1911 3 : : : cord-005453-4057qib7 1911 4 6/9 6/9 CD cord-005453-4057qib7 1911 5 alive alive JJ cord-005453-4057qib7 1911 6 patients patient NNS cord-005453-4057qib7 1911 7 i.e i.e NNP cord-005453-4057qib7 1911 8 66.6 66.6 CD cord-005453-4057qib7 1911 9 % % NN cord-005453-4057qib7 1911 10 exhibit exhibit NN cord-005453-4057qib7 1911 11 no no DT cord-005453-4057qib7 1911 12 fibrosis fibrosis NN cord-005453-4057qib7 1911 13 in in IN cord-005453-4057qib7 1911 14 trephine trephine JJ cord-005453-4057qib7 1911 15 biopsies biopsy NNS cord-005453-4057qib7 1911 16 , , . cord-005453-4057qib7 1912 1 1/9 1/9 CD cord-005453-4057qib7 1912 2 alive alive JJ cord-005453-4057qib7 1912 3 patients patient NNS cord-005453-4057qib7 1912 4 had have VBD cord-005453-4057qib7 1912 5 residual residual JJ cord-005453-4057qib7 1912 6 fibrosis fibrosis NN cord-005453-4057qib7 1912 7 but but CC cord-005453-4057qib7 1912 8 100 100 CD cord-005453-4057qib7 1912 9 % % NN cord-005453-4057qib7 1912 10 donor donor NN cord-005453-4057qib7 1912 11 chimerism chimerism NN cord-005453-4057qib7 1912 12 , , , cord-005453-4057qib7 1912 13 1/9 1/9 CD cord-005453-4057qib7 1912 14 alive alive JJ cord-005453-4057qib7 1912 15 patients patient NNS cord-005453-4057qib7 1912 16 had have VBD cord-005453-4057qib7 1912 17 residual residual JJ cord-005453-4057qib7 1912 18 fibrosis fibrosis NN cord-005453-4057qib7 1912 19 with with IN cord-005453-4057qib7 1912 20 mixed mixed JJ cord-005453-4057qib7 1912 21 donor donor NN cord-005453-4057qib7 1912 22 chimerism chimerism NN cord-005453-4057qib7 1912 23 , , , cord-005453-4057qib7 1912 24 other other JJ cord-005453-4057qib7 1912 25 patient patient NN cord-005453-4057qib7 1912 26 non non JJ cord-005453-4057qib7 1912 27 - - JJ cord-005453-4057qib7 1912 28 assessable assessable JJ cord-005453-4057qib7 1912 29 . . . cord-005453-4057qib7 1913 1 Conclusions conclusion NNS cord-005453-4057qib7 1913 2 : : : cord-005453-4057qib7 1914 1 Allo Allo NNP cord-005453-4057qib7 1914 2 - - HYPH cord-005453-4057qib7 1914 3 HSCT HSCT NNP cord-005453-4057qib7 1914 4 remains remain VBZ cord-005453-4057qib7 1914 5 the the DT cord-005453-4057qib7 1914 6 only only JJ cord-005453-4057qib7 1914 7 potentially potentially RB cord-005453-4057qib7 1914 8 curable curable JJ cord-005453-4057qib7 1914 9 option option NN cord-005453-4057qib7 1914 10 for for IN cord-005453-4057qib7 1914 11 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 1914 12 . . . cord-005453-4057qib7 1915 1 In in IN cord-005453-4057qib7 1915 2 our -PRON- PRP$ cord-005453-4057qib7 1915 3 centre centre NN cord-005453-4057qib7 1915 4 which which WDT cord-005453-4057qib7 1915 5 serves serve VBZ cord-005453-4057qib7 1915 6 1.1 1.1 CD cord-005453-4057qib7 1915 7 million million CD cord-005453-4057qib7 1915 8 population population NN cord-005453-4057qib7 1915 9 , , , cord-005453-4057qib7 1915 10 with with IN cord-005453-4057qib7 1915 11 12 12 CD cord-005453-4057qib7 1915 12 new new JJ cord-005453-4057qib7 1915 13 cases case NNS cord-005453-4057qib7 1915 14 per per IN cord-005453-4057qib7 1915 15 year year NN cord-005453-4057qib7 1915 16 , , , cord-005453-4057qib7 1915 17 12 12 CD cord-005453-4057qib7 1915 18 patients patient NNS cord-005453-4057qib7 1915 19 were be VBD cord-005453-4057qib7 1915 20 transplanted transplant VBN cord-005453-4057qib7 1915 21 since since IN cord-005453-4057qib7 1915 22 2010 2010 CD cord-005453-4057qib7 1915 23 . . . cord-005453-4057qib7 1916 1 Our -PRON- PRP$ cord-005453-4057qib7 1916 2 data datum NNS cord-005453-4057qib7 1916 3 suggest suggest VBP cord-005453-4057qib7 1916 4 that that IN cord-005453-4057qib7 1916 5 close close JJ cord-005453-4057qib7 1916 6 collaboration collaboration NN cord-005453-4057qib7 1916 7 between between IN cord-005453-4057qib7 1916 8 MPN MPN NNP cord-005453-4057qib7 1916 9 - - HYPH cord-005453-4057qib7 1916 10 treating treat VBG cord-005453-4057qib7 1916 11 haematologists haematologist NNS cord-005453-4057qib7 1916 12 and and CC cord-005453-4057qib7 1916 13 transplant transplant NN cord-005453-4057qib7 1916 14 physicians physician NNS cord-005453-4057qib7 1916 15 is be VBZ cord-005453-4057qib7 1916 16 required require VBN cord-005453-4057qib7 1916 17 so so IN cord-005453-4057qib7 1916 18 that that IN cord-005453-4057qib7 1916 19 all all DT cord-005453-4057qib7 1916 20 suitable suitable JJ cord-005453-4057qib7 1916 21 patients patient NNS cord-005453-4057qib7 1916 22 have have VBP cord-005453-4057qib7 1916 23 a a DT cord-005453-4057qib7 1916 24 transplant transplant NN cord-005453-4057qib7 1916 25 assessment assessment NN cord-005453-4057qib7 1916 26 early early RB cord-005453-4057qib7 1916 27 in in IN cord-005453-4057qib7 1916 28 their -PRON- PRP$ cord-005453-4057qib7 1916 29 disease disease NN cord-005453-4057qib7 1916 30 course course NN cord-005453-4057qib7 1916 31 . . . cord-005453-4057qib7 1917 1 Novel novel JJ cord-005453-4057qib7 1917 2 molecular molecular JJ cord-005453-4057qib7 1917 3 prognostic prognostic JJ cord-005453-4057qib7 1917 4 systems system NNS cord-005453-4057qib7 1917 5 are be VBP cord-005453-4057qib7 1917 6 likely likely JJ cord-005453-4057qib7 1917 7 to to TO cord-005453-4057qib7 1917 8 identify identify VB cord-005453-4057qib7 1917 9 those those DT cord-005453-4057qib7 1917 10 best well RBS cord-005453-4057qib7 1917 11 placed place VBN cord-005453-4057qib7 1917 12 to to TO cord-005453-4057qib7 1917 13 benefit benefit VB cord-005453-4057qib7 1917 14 in in IN cord-005453-4057qib7 1917 15 future future NN cord-005453-4057qib7 1917 16 but but CC cord-005453-4057qib7 1917 17 this this DT cord-005453-4057qib7 1917 18 series series NN cord-005453-4057qib7 1917 19 currently currently RB cord-005453-4057qib7 1917 20 supports support VBZ cord-005453-4057qib7 1917 21 allo allo NN cord-005453-4057qib7 1917 22 - - HYPH cord-005453-4057qib7 1917 23 HSCT HSCT NNP cord-005453-4057qib7 1917 24 survival survival NN cord-005453-4057qib7 1917 25 and and CC cord-005453-4057qib7 1917 26 cure cure NN cord-005453-4057qib7 1917 27 . . . cord-005453-4057qib7 1918 1 ( ( -LRB- cord-005453-4057qib7 1918 2 range range NN cord-005453-4057qib7 1918 3 , , , cord-005453-4057qib7 1918 4 105 105 CD cord-005453-4057qib7 1918 5 - - SYM cord-005453-4057qib7 1918 6 4624 4624 CD cord-005453-4057qib7 1918 7 ) ) -RRB- cord-005453-4057qib7 1918 8 . . . cord-005453-4057qib7 1919 1 Dynamic dynamic JJ cord-005453-4057qib7 1919 2 international international JJ cord-005453-4057qib7 1919 3 prognostic prognostic JJ cord-005453-4057qib7 1919 4 scoring scoring NN cord-005453-4057qib7 1919 5 system system NN cord-005453-4057qib7 1919 6 ( ( -LRB- cord-005453-4057qib7 1919 7 DIPSS DIPSS NNP cord-005453-4057qib7 1919 8 ) ) -RRB- cord-005453-4057qib7 1919 9 score score NN cord-005453-4057qib7 1919 10 at at IN cord-005453-4057qib7 1919 11 the the DT cord-005453-4057qib7 1919 12 time time NN cord-005453-4057qib7 1919 13 of of IN cord-005453-4057qib7 1919 14 HCT HCT NNP cord-005453-4057qib7 1919 15 was be VBD cord-005453-4057qib7 1919 16 intermediate-2 intermediate-2 NNP cord-005453-4057qib7 1919 17 or or CC cord-005453-4057qib7 1919 18 high high JJ cord-005453-4057qib7 1919 19 risk risk NN cord-005453-4057qib7 1919 20 in in IN cord-005453-4057qib7 1919 21 20 20 CD cord-005453-4057qib7 1919 22 patients patient NNS cord-005453-4057qib7 1919 23 ( ( -LRB- cord-005453-4057qib7 1919 24 95 95 CD cord-005453-4057qib7 1919 25 % % NN cord-005453-4057qib7 1919 26 ) ) -RRB- cord-005453-4057qib7 1919 27 , , , cord-005453-4057qib7 1919 28 intermedate-1 intermedate-1 NNP cord-005453-4057qib7 1919 29 in in IN cord-005453-4057qib7 1919 30 1 1 CD cord-005453-4057qib7 1919 31 patient patient NN cord-005453-4057qib7 1919 32 . . . cord-005453-4057qib7 1920 1 Molecular molecular JJ cord-005453-4057qib7 1920 2 evaluation evaluation NN cord-005453-4057qib7 1920 3 was be VBD cord-005453-4057qib7 1920 4 available available JJ cord-005453-4057qib7 1920 5 in in IN cord-005453-4057qib7 1920 6 14 14 CD cord-005453-4057qib7 1920 7 out out IN cord-005453-4057qib7 1920 8 of of IN cord-005453-4057qib7 1920 9 21 21 CD cord-005453-4057qib7 1920 10 : : : cord-005453-4057qib7 1921 1 JAK2 JAK2 NNP cord-005453-4057qib7 1921 2 V617F v617f NN cord-005453-4057qib7 1921 3 mutation mutation NN cord-005453-4057qib7 1921 4 was be VBD cord-005453-4057qib7 1921 5 detectable detectable JJ cord-005453-4057qib7 1921 6 in in IN cord-005453-4057qib7 1921 7 8 8 CD cord-005453-4057qib7 1921 8 patients patient NNS cord-005453-4057qib7 1921 9 , , , cord-005453-4057qib7 1921 10 MPL MPL NNP cord-005453-4057qib7 1921 11 - - : cord-005453-4057qib7 1921 12 W515 W515 NNPS cord-005453-4057qib7 1921 13 K K NNP cord-005453-4057qib7 1921 14 in in IN cord-005453-4057qib7 1921 15 1 1 CD cord-005453-4057qib7 1921 16 patient patient NN cord-005453-4057qib7 1921 17 , , , cord-005453-4057qib7 1921 18 CARL CARL NNP cord-005453-4057qib7 1921 19 in in IN cord-005453-4057qib7 1921 20 1 1 CD cord-005453-4057qib7 1921 21 patient patient NN cord-005453-4057qib7 1921 22 . . . cord-005453-4057qib7 1922 1 4 4 CD cord-005453-4057qib7 1922 2 patients patient NNS cord-005453-4057qib7 1922 3 were be VBD cord-005453-4057qib7 1922 4 " " `` cord-005453-4057qib7 1922 5 triple triple JJ cord-005453-4057qib7 1922 6 negative negative JJ cord-005453-4057qib7 1922 7 " " '' cord-005453-4057qib7 1922 8 for for IN cord-005453-4057qib7 1922 9 driver driver NN cord-005453-4057qib7 1922 10 mutations mutation NNS cord-005453-4057qib7 1922 11 . . . cord-005453-4057qib7 1923 1 Cytogenetics cytogenetic NNS cord-005453-4057qib7 1923 2 information information NN cord-005453-4057qib7 1923 3 was be VBD cord-005453-4057qib7 1923 4 available available JJ cord-005453-4057qib7 1923 5 for for IN cord-005453-4057qib7 1923 6 6 6 CD cord-005453-4057qib7 1923 7 out out IN cord-005453-4057qib7 1923 8 of of IN cord-005453-4057qib7 1923 9 21 21 CD cord-005453-4057qib7 1923 10 ; ; : cord-005453-4057qib7 1923 11 among among IN cord-005453-4057qib7 1923 12 which which WDT cord-005453-4057qib7 1923 13 3 3 CD cord-005453-4057qib7 1923 14 patients patient NNS cord-005453-4057qib7 1923 15 had have VBD cord-005453-4057qib7 1923 16 complex complex JJ cord-005453-4057qib7 1923 17 karyotype karyotype NN cord-005453-4057qib7 1923 18 , , , cord-005453-4057qib7 1923 19 1 1 CD cord-005453-4057qib7 1923 20 trisomy trisomy NN cord-005453-4057qib7 1923 21 8 8 CD cord-005453-4057qib7 1923 22 and and CC cord-005453-4057qib7 1923 23 1 1 CD cord-005453-4057qib7 1923 24 trisomy trisomy NN cord-005453-4057qib7 1923 25 9 9 CD cord-005453-4057qib7 1923 26 . . . cord-005453-4057qib7 1924 1 3 3 CD cord-005453-4057qib7 1924 2 patients patient NNS cord-005453-4057qib7 1924 3 underwent undergo VBD cord-005453-4057qib7 1924 4 splenectomy splenectomy NN cord-005453-4057qib7 1924 5 before before IN cord-005453-4057qib7 1924 6 HCT HCT NNP cord-005453-4057qib7 1924 7 . . . cord-005453-4057qib7 1925 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 1925 2 was be VBD cord-005453-4057qib7 1925 3 administered administer VBN cord-005453-4057qib7 1925 4 in in IN cord-005453-4057qib7 1925 5 4 4 CD cord-005453-4057qib7 1925 6 patients patient NNS cord-005453-4057qib7 1925 7 before before IN cord-005453-4057qib7 1925 8 HCT HCT NNP cord-005453-4057qib7 1925 9 . . . cord-005453-4057qib7 1926 1 10 10 CD cord-005453-4057qib7 1926 2 ( ( -LRB- cord-005453-4057qib7 1926 3 48 48 CD cord-005453-4057qib7 1926 4 % % NN cord-005453-4057qib7 1926 5 ) ) -RRB- cord-005453-4057qib7 1926 6 patients patient NNS cord-005453-4057qib7 1926 7 received receive VBD cord-005453-4057qib7 1926 8 stem stem NN cord-005453-4057qib7 1926 9 cells cell NNS cord-005453-4057qib7 1926 10 from from IN cord-005453-4057qib7 1926 11 an an DT cord-005453-4057qib7 1926 12 HLA HLA NNP cord-005453-4057qib7 1926 13 identical identical JJ cord-005453-4057qib7 1926 14 sibling sibling NN cord-005453-4057qib7 1926 15 , , , cord-005453-4057qib7 1926 16 9 9 CD cord-005453-4057qib7 1926 17 ( ( -LRB- cord-005453-4057qib7 1926 18 42 42 CD cord-005453-4057qib7 1926 19 % % NN cord-005453-4057qib7 1926 20 ) ) -RRB- cord-005453-4057qib7 1926 21 from from IN cord-005453-4057qib7 1926 22 a a DT cord-005453-4057qib7 1926 23 matched match VBN cord-005453-4057qib7 1926 24 unrelated unrelated JJ cord-005453-4057qib7 1926 25 donor donor NN cord-005453-4057qib7 1926 26 and and CC cord-005453-4057qib7 1926 27 2 2 CD cord-005453-4057qib7 1926 28 ( ( -LRB- cord-005453-4057qib7 1926 29 10 10 CD cord-005453-4057qib7 1926 30 % % NN cord-005453-4057qib7 1926 31 ) ) -RRB- cord-005453-4057qib7 1926 32 from from IN cord-005453-4057qib7 1926 33 an an DT cord-005453-4057qib7 1926 34 haploidentical haploidentical JJ cord-005453-4057qib7 1926 35 sibling sibling NN cord-005453-4057qib7 1926 36 . . . cord-005453-4057qib7 1927 1 Graft graft NN cord-005453-4057qib7 1927 2 source source NN cord-005453-4057qib7 1927 3 was be VBD cord-005453-4057qib7 1927 4 bone bone NN cord-005453-4057qib7 1927 5 marrow marrow NN cord-005453-4057qib7 1927 6 in in IN cord-005453-4057qib7 1927 7 7 7 CD cord-005453-4057qib7 1927 8 patients patient NNS cord-005453-4057qib7 1927 9 ( ( -LRB- cord-005453-4057qib7 1927 10 34 34 CD cord-005453-4057qib7 1927 11 % % NN cord-005453-4057qib7 1927 12 ) ) -RRB- cord-005453-4057qib7 1927 13 and and CC cord-005453-4057qib7 1927 14 peripheral peripheral JJ cord-005453-4057qib7 1927 15 blood blood NN cord-005453-4057qib7 1927 16 in in IN cord-005453-4057qib7 1927 17 14 14 CD cord-005453-4057qib7 1927 18 ( ( -LRB- cord-005453-4057qib7 1927 19 66 66 CD cord-005453-4057qib7 1927 20 % % NN cord-005453-4057qib7 1927 21 ) ) -RRB- cord-005453-4057qib7 1927 22 . . . cord-005453-4057qib7 1928 1 Conditioning conditioning NN cord-005453-4057qib7 1928 2 was be VBD cord-005453-4057qib7 1928 3 myeloablative myeloablative JJ cord-005453-4057qib7 1928 4 in in IN cord-005453-4057qib7 1928 5 16 16 CD cord-005453-4057qib7 1928 6 patients patient NNS cord-005453-4057qib7 1928 7 ( ( -LRB- cord-005453-4057qib7 1928 8 76 76 CD cord-005453-4057qib7 1928 9 % % NN cord-005453-4057qib7 1928 10 ) ) -RRB- cord-005453-4057qib7 1928 11 , , , cord-005453-4057qib7 1928 12 reduced reduce VBN cord-005453-4057qib7 1928 13 intensity intensity NN cord-005453-4057qib7 1928 14 in in IN cord-005453-4057qib7 1928 15 5 5 CD cord-005453-4057qib7 1928 16 ( ( -LRB- cord-005453-4057qib7 1928 17 24 24 CD cord-005453-4057qib7 1928 18 % % NN cord-005453-4057qib7 1928 19 ) ) -RRB- cord-005453-4057qib7 1928 20 . . . cord-005453-4057qib7 1929 1 All all DT cord-005453-4057qib7 1929 2 patients patient NNS cord-005453-4057qib7 1929 3 engrafted engraft VBD cord-005453-4057qib7 1929 4 . . . cord-005453-4057qib7 1930 1 Acute acute JJ cord-005453-4057qib7 1930 2 graft graft NN cord-005453-4057qib7 1930 3 versus versus IN cord-005453-4057qib7 1930 4 host host NN cord-005453-4057qib7 1930 5 disease disease NN cord-005453-4057qib7 1930 6 was be VBD cord-005453-4057qib7 1930 7 absent absent JJ cord-005453-4057qib7 1930 8 in in IN cord-005453-4057qib7 1930 9 12 12 CD cord-005453-4057qib7 1930 10 patients patient NNS cord-005453-4057qib7 1930 11 ( ( -LRB- cord-005453-4057qib7 1930 12 57 57 CD cord-005453-4057qib7 1930 13 % % NN cord-005453-4057qib7 1930 14 ) ) -RRB- cord-005453-4057qib7 1930 15 , , , cord-005453-4057qib7 1930 16 grade grade NN cord-005453-4057qib7 1930 17 I I NNP cord-005453-4057qib7 1930 18 - - HYPH cord-005453-4057qib7 1930 19 II II NNP cord-005453-4057qib7 1930 20 in in IN cord-005453-4057qib7 1930 21 7 7 CD cord-005453-4057qib7 1930 22 ( ( -LRB- cord-005453-4057qib7 1930 23 34 34 CD cord-005453-4057qib7 1930 24 % % NN cord-005453-4057qib7 1930 25 ) ) -RRB- cord-005453-4057qib7 1930 26 , , , cord-005453-4057qib7 1930 27 grade grade NN cord-005453-4057qib7 1930 28 III III NNP cord-005453-4057qib7 1930 29 - - HYPH cord-005453-4057qib7 1930 30 IV IV NNP cord-005453-4057qib7 1930 31 in in IN cord-005453-4057qib7 1930 32 2 2 CD cord-005453-4057qib7 1930 33 ( ( -LRB- cord-005453-4057qib7 1930 34 9 9 CD cord-005453-4057qib7 1930 35 % % NN cord-005453-4057qib7 1930 36 ) ) -RRB- cord-005453-4057qib7 1930 37 . . . cord-005453-4057qib7 1931 1 In in IN cord-005453-4057qib7 1931 2 18 18 CD cord-005453-4057qib7 1931 3 evaluable evaluable JJ cord-005453-4057qib7 1931 4 patients patient NNS cord-005453-4057qib7 1931 5 chronic chronic JJ cord-005453-4057qib7 1931 6 graft graft NN cord-005453-4057qib7 1931 7 versus versus IN cord-005453-4057qib7 1931 8 host host NN cord-005453-4057qib7 1931 9 disease disease NN cord-005453-4057qib7 1931 10 was be VBD cord-005453-4057qib7 1931 11 limited limit VBN cord-005453-4057qib7 1931 12 in in IN cord-005453-4057qib7 1931 13 3 3 CD cord-005453-4057qib7 1931 14 ( ( -LRB- cord-005453-4057qib7 1931 15 17 17 CD cord-005453-4057qib7 1931 16 % % NN cord-005453-4057qib7 1931 17 ) ) -RRB- cord-005453-4057qib7 1931 18 , , , cord-005453-4057qib7 1931 19 extensive extensive JJ cord-005453-4057qib7 1931 20 in in IN cord-005453-4057qib7 1931 21 4 4 CD cord-005453-4057qib7 1931 22 ( ( -LRB- cord-005453-4057qib7 1931 23 22 22 CD cord-005453-4057qib7 1931 24 % % NN cord-005453-4057qib7 1931 25 ) ) -RRB- cord-005453-4057qib7 1931 26 and and CC cord-005453-4057qib7 1931 27 absent absent JJ cord-005453-4057qib7 1931 28 in in IN cord-005453-4057qib7 1931 29 11 11 CD cord-005453-4057qib7 1931 30 ( ( -LRB- cord-005453-4057qib7 1931 31 61 61 CD cord-005453-4057qib7 1931 32 % % NN cord-005453-4057qib7 1931 33 ) ) -RRB- cord-005453-4057qib7 1931 34 . . . cord-005453-4057qib7 1932 1 Transplantrelated transplantrelate VBN cord-005453-4057qib7 1932 2 mortality mortality NN cord-005453-4057qib7 1932 3 at at IN cord-005453-4057qib7 1932 4 180 180 CD cord-005453-4057qib7 1932 5 days day NNS cord-005453-4057qib7 1932 6 was be VBD cord-005453-4057qib7 1932 7 24 24 CD cord-005453-4057qib7 1932 8 % % NN cord-005453-4057qib7 1932 9 . . . cord-005453-4057qib7 1933 1 Main main JJ cord-005453-4057qib7 1933 2 causes cause NNS cord-005453-4057qib7 1933 3 of of IN cord-005453-4057qib7 1933 4 death death NN cord-005453-4057qib7 1933 5 were be VBD cord-005453-4057qib7 1933 6 : : : cord-005453-4057qib7 1933 7 acute acute JJ cord-005453-4057qib7 1933 8 GvHD gvhd NN cord-005453-4057qib7 1933 9 in in IN cord-005453-4057qib7 1933 10 2 2 CD cord-005453-4057qib7 1933 11 patients patient NNS cord-005453-4057qib7 1933 12 , , , cord-005453-4057qib7 1933 13 chronic chronic JJ cord-005453-4057qib7 1933 14 GvHD gvhd NN cord-005453-4057qib7 1933 15 in in IN cord-005453-4057qib7 1933 16 1 1 CD cord-005453-4057qib7 1933 17 , , , cord-005453-4057qib7 1933 18 pancreatitis pancreatitis NN cord-005453-4057qib7 1933 19 in in IN cord-005453-4057qib7 1933 20 1 1 CD cord-005453-4057qib7 1933 21 , , , cord-005453-4057qib7 1933 22 pulmonary pulmonary JJ cord-005453-4057qib7 1933 23 aspergillosis aspergillosis NN cord-005453-4057qib7 1933 24 in in IN cord-005453-4057qib7 1933 25 1 1 CD cord-005453-4057qib7 1933 26 . . . cord-005453-4057qib7 1934 1 Relapse relapse NN cord-005453-4057qib7 1934 2 occurred occur VBD cord-005453-4057qib7 1934 3 in in IN cord-005453-4057qib7 1934 4 7 7 CD cord-005453-4057qib7 1934 5 patients patient NNS cord-005453-4057qib7 1934 6 and and CC cord-005453-4057qib7 1934 7 was be VBD cord-005453-4057qib7 1934 8 the the DT cord-005453-4057qib7 1934 9 main main JJ cord-005453-4057qib7 1934 10 cause cause NN cord-005453-4057qib7 1934 11 of of IN cord-005453-4057qib7 1934 12 death death NN cord-005453-4057qib7 1934 13 in in IN cord-005453-4057qib7 1934 14 4 4 CD cord-005453-4057qib7 1934 15 of of IN cord-005453-4057qib7 1934 16 them -PRON- PRP cord-005453-4057qib7 1934 17 . . . cord-005453-4057qib7 1935 1 Notably notably RB cord-005453-4057qib7 1935 2 , , , cord-005453-4057qib7 1935 3 2 2 CD cord-005453-4057qib7 1935 4 patients patient NNS cord-005453-4057qib7 1935 5 experienced experience VBN cord-005453-4057qib7 1935 6 late late JJ cord-005453-4057qib7 1935 7 relapse relapse NN cord-005453-4057qib7 1935 8 after after IN cord-005453-4057qib7 1935 9 6.6 6.6 CD cord-005453-4057qib7 1935 10 and and CC cord-005453-4057qib7 1935 11 17.6 17.6 CD cord-005453-4057qib7 1935 12 years year NNS cord-005453-4057qib7 1935 13 after after IN cord-005453-4057qib7 1935 14 HCT HCT NNP cord-005453-4057qib7 1935 15 . . . cord-005453-4057qib7 1936 1 Both both DT cord-005453-4057qib7 1936 2 of of IN cord-005453-4057qib7 1936 3 them -PRON- PRP cord-005453-4057qib7 1936 4 are be VBP cord-005453-4057qib7 1936 5 living live VBG cord-005453-4057qib7 1936 6 while while IN cord-005453-4057qib7 1936 7 receiving receive VBG cord-005453-4057qib7 1936 8 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 1936 9 therapy therapy NN cord-005453-4057qib7 1936 10 . . . cord-005453-4057qib7 1937 1 After after IN cord-005453-4057qib7 1937 2 a a DT cord-005453-4057qib7 1937 3 median median NN cord-005453-4057qib7 1937 4 follow follow NN cord-005453-4057qib7 1937 5 up up IN cord-005453-4057qib7 1937 6 of of IN cord-005453-4057qib7 1937 7 581 581 CD cord-005453-4057qib7 1937 8 days day NNS cord-005453-4057qib7 1937 9 ( ( -LRB- cord-005453-4057qib7 1937 10 range range NN cord-005453-4057qib7 1937 11 , , , cord-005453-4057qib7 1937 12 38 38 CD cord-005453-4057qib7 1937 13 - - HYPH cord-005453-4057qib7 1937 14 11660 11660 CD cord-005453-4057qib7 1937 15 ) ) -RRB- cord-005453-4057qib7 1937 16 , , , cord-005453-4057qib7 1937 17 10 10 CD cord-005453-4057qib7 1937 18 out out IN cord-005453-4057qib7 1937 19 of of IN cord-005453-4057qib7 1937 20 21 21 CD cord-005453-4057qib7 1937 21 patients patient NNS cord-005453-4057qib7 1937 22 are be VBP cord-005453-4057qib7 1937 23 alive alive JJ cord-005453-4057qib7 1937 24 . . . cord-005453-4057qib7 1938 1 7 7 CD cord-005453-4057qib7 1938 2 of of IN cord-005453-4057qib7 1938 3 them -PRON- PRP cord-005453-4057qib7 1938 4 ( ( -LRB- cord-005453-4057qib7 1938 5 33 33 CD cord-005453-4057qib7 1938 6 % % NN cord-005453-4057qib7 1938 7 ) ) -RRB- cord-005453-4057qib7 1938 8 are be VBP cord-005453-4057qib7 1938 9 disease disease NN cord-005453-4057qib7 1938 10 - - HYPH cord-005453-4057qib7 1938 11 free free JJ cord-005453-4057qib7 1938 12 and and CC cord-005453-4057qib7 1938 13 3 3 CD cord-005453-4057qib7 1938 14 are be VBP cord-005453-4057qib7 1938 15 living live VBG cord-005453-4057qib7 1938 16 . . . cord-005453-4057qib7 1939 1 The the DT cord-005453-4057qib7 1939 2 Kaplan Kaplan NNP cord-005453-4057qib7 1939 3 - - HYPH cord-005453-4057qib7 1939 4 Meyer Meyer NNP cord-005453-4057qib7 1939 5 overall overall JJ cord-005453-4057qib7 1939 6 survival survival NN cord-005453-4057qib7 1939 7 and and CC cord-005453-4057qib7 1939 8 disease disease NN cord-005453-4057qib7 1939 9 - - HYPH cord-005453-4057qib7 1939 10 free free JJ cord-005453-4057qib7 1939 11 survival survival NN cord-005453-4057qib7 1939 12 at at IN cord-005453-4057qib7 1939 13 10 10 CD cord-005453-4057qib7 1939 14 years year NNS cord-005453-4057qib7 1939 15 was be VBD cord-005453-4057qib7 1939 16 40 40 CD cord-005453-4057qib7 1939 17 % % NN cord-005453-4057qib7 1939 18 and and CC cord-005453-4057qib7 1939 19 35 35 CD cord-005453-4057qib7 1939 20 % % NN cord-005453-4057qib7 1939 21 , , , cord-005453-4057qib7 1939 22 respectively respectively RB cord-005453-4057qib7 1939 23 . . . cord-005453-4057qib7 1940 1 Conclusions conclusion NNS cord-005453-4057qib7 1940 2 : : : cord-005453-4057qib7 1941 1 Our -PRON- PRP$ cord-005453-4057qib7 1941 2 experience experience NN cord-005453-4057qib7 1941 3 confirms confirm VBZ cord-005453-4057qib7 1941 4 that that IN cord-005453-4057qib7 1941 5 HCT HCT NNP cord-005453-4057qib7 1941 6 is be VBZ cord-005453-4057qib7 1941 7 a a DT cord-005453-4057qib7 1941 8 valid valid JJ cord-005453-4057qib7 1941 9 option option NN cord-005453-4057qib7 1941 10 to to TO cord-005453-4057qib7 1941 11 achieve achieve VB cord-005453-4057qib7 1941 12 cure cure NN cord-005453-4057qib7 1941 13 in in IN cord-005453-4057qib7 1941 14 one one CD cord-005453-4057qib7 1941 15 third third NN cord-005453-4057qib7 1941 16 of of IN cord-005453-4057qib7 1941 17 MF MF NNP cord-005453-4057qib7 1941 18 patients patient NNS cord-005453-4057qib7 1941 19 . . . cord-005453-4057qib7 1942 1 Two two CD cord-005453-4057qib7 1942 2 patients patient NNS cord-005453-4057qib7 1942 3 experienced experience VBD cord-005453-4057qib7 1942 4 very very RB cord-005453-4057qib7 1942 5 late late RB cord-005453-4057qib7 1942 6 ( ( -LRB- cord-005453-4057qib7 1942 7 > > NFP cord-005453-4057qib7 1942 8 5 5 CD cord-005453-4057qib7 1942 9 years year NNS cord-005453-4057qib7 1942 10 ) ) -RRB- cord-005453-4057qib7 1942 11 recurrence recurrence NN cord-005453-4057qib7 1942 12 of of IN cord-005453-4057qib7 1942 13 MF MF NNP cord-005453-4057qib7 1942 14 . . . cord-005453-4057qib7 1943 1 The the DT cord-005453-4057qib7 1943 2 rarity rarity NN cord-005453-4057qib7 1943 3 of of IN cord-005453-4057qib7 1943 4 this this DT cord-005453-4057qib7 1943 5 condition condition NN cord-005453-4057qib7 1943 6 limits limit VBZ cord-005453-4057qib7 1943 7 the the DT cord-005453-4057qib7 1943 8 amount amount NN cord-005453-4057qib7 1943 9 of of IN cord-005453-4057qib7 1943 10 data datum NNS cord-005453-4057qib7 1943 11 and and CC cord-005453-4057qib7 1943 12 cases case NNS cord-005453-4057qib7 1943 13 available available JJ cord-005453-4057qib7 1943 14 for for IN cord-005453-4057qib7 1943 15 evaluation evaluation NN cord-005453-4057qib7 1943 16 and and CC cord-005453-4057qib7 1943 17 study study NN cord-005453-4057qib7 1943 18 . . . cord-005453-4057qib7 1944 1 Life life NN cord-005453-4057qib7 1944 2 - - HYPH cord-005453-4057qib7 1944 3 long long JJ cord-005453-4057qib7 1944 4 follow follow NN cord-005453-4057qib7 1944 5 - - HYPH cord-005453-4057qib7 1944 6 up up NN cord-005453-4057qib7 1944 7 of of IN cord-005453-4057qib7 1944 8 all all DT cord-005453-4057qib7 1944 9 MF MF NNP cord-005453-4057qib7 1944 10 transplanted transplant VBN cord-005453-4057qib7 1944 11 patients patient NNS cord-005453-4057qib7 1944 12 is be VBZ cord-005453-4057qib7 1944 13 warranted warrant VBN cord-005453-4057qib7 1944 14 to to TO cord-005453-4057qib7 1944 15 better well RBR cord-005453-4057qib7 1944 16 understand understand VB cord-005453-4057qib7 1944 17 this this DT cord-005453-4057qib7 1944 18 rare rare JJ cord-005453-4057qib7 1944 19 event event NN cord-005453-4057qib7 1944 20 . . . cord-005453-4057qib7 1945 1 Disclosure disclosure NN cord-005453-4057qib7 1945 2 : : : cord-005453-4057qib7 1945 3 Nothing nothing NN cord-005453-4057qib7 1945 4 to to TO cord-005453-4057qib7 1945 5 declare declare VB cord-005453-4057qib7 1945 6 Methods method NNS cord-005453-4057qib7 1945 7 : : : cord-005453-4057qib7 1945 8 А а JJ cord-005453-4057qib7 1945 9 37-years 37-years CD cord-005453-4057qib7 1945 10 old old JJ cord-005453-4057qib7 1945 11 female female NN cord-005453-4057qib7 1945 12 was be VBD cord-005453-4057qib7 1945 13 diagnosed diagnose VBN cord-005453-4057qib7 1945 14 with with IN cord-005453-4057qib7 1945 15 JAK2V617F jak2v617f JJ cord-005453-4057qib7 1945 16 - - HYPH cord-005453-4057qib7 1945 17 positive positive JJ cord-005453-4057qib7 1945 18 PMF PMF NNP cord-005453-4057qib7 1945 19 , , , cord-005453-4057qib7 1945 20 46XX 46xx CD cord-005453-4057qib7 1945 21 , , , cord-005453-4057qib7 1945 22 IPSS IPSS NNP cord-005453-4057qib7 1945 23 low low JJ cord-005453-4057qib7 1945 24 risk risk NN cord-005453-4057qib7 1945 25 , , , cord-005453-4057qib7 1945 26 DIPSSplus dipssplus NN cord-005453-4057qib7 1945 27 intermediate intermediate JJ cord-005453-4057qib7 1945 28 -2 -2 CD cord-005453-4057qib7 1945 29 risk risk NN cord-005453-4057qib7 1945 30 , , , cord-005453-4057qib7 1945 31 subacute subacute JJ cord-005453-4057qib7 1945 32 Budd Budd NNP cord-005453-4057qib7 1945 33 - - HYPH cord-005453-4057qib7 1945 34 Chiari Chiari NNP cord-005453-4057qib7 1945 35 syndrome syndrome NN cord-005453-4057qib7 1945 36 and and CC cord-005453-4057qib7 1945 37 portal portal JJ cord-005453-4057qib7 1945 38 vein vein NN cord-005453-4057qib7 1945 39 thrombosis thrombosis NN cord-005453-4057qib7 1945 40 four four CD cord-005453-4057qib7 1945 41 years year NNS cord-005453-4057qib7 1945 42 before before IN cord-005453-4057qib7 1945 43 alloHSCT alloHSCT NNP cord-005453-4057qib7 1945 44 . . . cord-005453-4057qib7 1946 1 To to TO cord-005453-4057qib7 1946 2 reduce reduce VB cord-005453-4057qib7 1946 3 the the DT cord-005453-4057qib7 1946 4 splenomegaly splenomegaly JJ cord-005453-4057qib7 1946 5 and and CC cord-005453-4057qib7 1946 6 constitutional constitutional JJ cord-005453-4057qib7 1946 7 symptoms symptom NNS cord-005453-4057qib7 1946 8 we -PRON- PRP cord-005453-4057qib7 1946 9 performed perform VBD cord-005453-4057qib7 1946 10 pre pre JJ cord-005453-4057qib7 1946 11 - - JJ cord-005453-4057qib7 1946 12 transplant transplant JJ cord-005453-4057qib7 1946 13 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 1946 14 therapy therapy NNP cord-005453-4057qib7 1946 15 30 30 CD cord-005453-4057qib7 1946 16 mg mg NNP cord-005453-4057qib7 1946 17 daily daily RB cord-005453-4057qib7 1946 18 . . . cord-005453-4057qib7 1947 1 After after IN cord-005453-4057qib7 1947 2 three three CD cord-005453-4057qib7 1947 3 months month NNS cord-005453-4057qib7 1947 4 of of IN cord-005453-4057qib7 1947 5 therapy therapy NN cord-005453-4057qib7 1947 6 the the DT cord-005453-4057qib7 1947 7 patient patient NN cord-005453-4057qib7 1947 8 achieved achieve VBD cord-005453-4057qib7 1947 9 clinical clinical JJ cord-005453-4057qib7 1947 10 improvement improvement NN cord-005453-4057qib7 1947 11 ( ( -LRB- cord-005453-4057qib7 1947 12 ELN ELN NNP cord-005453-4057qib7 1947 13 criteria criterion NNS cord-005453-4057qib7 1947 14 ) ) -RRB- cord-005453-4057qib7 1947 15 . . . cord-005453-4057qib7 1948 1 Contrast contrast NN cord-005453-4057qib7 1948 2 - - HYPH cord-005453-4057qib7 1948 3 enhanced enhance VBN cord-005453-4057qib7 1948 4 computer computer NN cord-005453-4057qib7 1948 5 tomography tomography NN cord-005453-4057qib7 1948 6 and and CC cord-005453-4057qib7 1948 7 magnetic magnetic JJ cord-005453-4057qib7 1948 8 resonance resonance NN cord-005453-4057qib7 1948 9 imaging imaging NN cord-005453-4057qib7 1948 10 showed show VBD cord-005453-4057qib7 1948 11 enlarged enlarge VBN cord-005453-4057qib7 1948 12 intrahepatic intrahepatic JJ cord-005453-4057qib7 1948 13 collateral collateral JJ cord-005453-4057qib7 1948 14 vessels vessel NNS cord-005453-4057qib7 1948 15 and and CC cord-005453-4057qib7 1948 16 signs sign NNS cord-005453-4057qib7 1948 17 of of IN cord-005453-4057qib7 1948 18 portal portal JJ cord-005453-4057qib7 1948 19 vein vein NN cord-005453-4057qib7 1948 20 thrombosis thrombosis NN cord-005453-4057qib7 1948 21 with with IN cord-005453-4057qib7 1948 22 cavernous cavernous JJ cord-005453-4057qib7 1948 23 transformation transformation NN cord-005453-4057qib7 1948 24 and and CC cord-005453-4057qib7 1948 25 multiple multiple JJ cord-005453-4057qib7 1948 26 dilated dilated JJ cord-005453-4057qib7 1948 27 collateral collateral JJ cord-005453-4057qib7 1948 28 veins vein NNS cord-005453-4057qib7 1948 29 . . . cord-005453-4057qib7 1949 1 Gastroscopy Gastroscopy NNP cord-005453-4057qib7 1949 2 documented document VBD cord-005453-4057qib7 1949 3 enlarged enlarged JJ cord-005453-4057qib7 1949 4 esophageal esophageal JJ cord-005453-4057qib7 1949 5 veins vein NNS cord-005453-4057qib7 1949 6 . . . cord-005453-4057qib7 1950 1 Allogeneic allogeneic IN cord-005453-4057qib7 1950 2 stem stem VBP cord-005453-4057qib7 1950 3 cell cell NN cord-005453-4057qib7 1950 4 transplantation transplantation NN cord-005453-4057qib7 1950 5 was be VBD cord-005453-4057qib7 1950 6 performed perform VBN cord-005453-4057qib7 1950 7 from from IN cord-005453-4057qib7 1950 8 10/10 10/10 CD cord-005453-4057qib7 1950 9 -HLA -HLA HYPH cord-005453-4057qib7 1950 10 matched match VBN cord-005453-4057qib7 1950 11 unrelated unrelated JJ cord-005453-4057qib7 1950 12 donor donor NN cord-005453-4057qib7 1950 13 with with IN cord-005453-4057qib7 1950 14 peripheral peripheral JJ cord-005453-4057qib7 1950 15 stem stem NN cord-005453-4057qib7 1950 16 cells cell NNS cord-005453-4057qib7 1950 17 ( ( -LRB- cord-005453-4057qib7 1950 18 6.1 6.1 CD cord-005453-4057qib7 1950 19 x x SYM cord-005453-4057qib7 1950 20 10 10 CD cord-005453-4057qib7 1950 21 9 9 CD cord-005453-4057qib7 1950 22 СD34 СD34 NNP cord-005453-4057qib7 1950 23 + + CC cord-005453-4057qib7 1950 24 cells cell NNS cord-005453-4057qib7 1950 25 / / SYM cord-005453-4057qib7 1950 26 kg kg NN cord-005453-4057qib7 1950 27 ) ) -RRB- cord-005453-4057qib7 1950 28 . . . cord-005453-4057qib7 1951 1 Conditioning conditioning NN cord-005453-4057qib7 1951 2 regimen regimen NN cord-005453-4057qib7 1951 3 consisted consist VBD cord-005453-4057qib7 1951 4 of of IN cord-005453-4057qib7 1951 5 fludarabine fludarabine NN cord-005453-4057qib7 1951 6 ( ( -LRB- cord-005453-4057qib7 1951 7 180 180 CD cord-005453-4057qib7 1951 8 mg/ mg/ NN cord-005453-4057qib7 1951 9 m m CD cord-005453-4057qib7 1951 10 2 2 CD cord-005453-4057qib7 1951 11 ) ) -RRB- cord-005453-4057qib7 1951 12 , , , cord-005453-4057qib7 1951 13 busulfan busulfan NNP cord-005453-4057qib7 1951 14 ( ( -LRB- cord-005453-4057qib7 1951 15 10 10 CD cord-005453-4057qib7 1951 16 mg mg NNP cord-005453-4057qib7 1951 17 / / SYM cord-005453-4057qib7 1951 18 kg kg NNP cord-005453-4057qib7 1951 19 p.o p.o NNP cord-005453-4057qib7 1951 20 . . NNP cord-005453-4057qib7 1951 21 ) ) -RRB- cord-005453-4057qib7 1951 22 . . . cord-005453-4057qib7 1952 1 Post post JJ cord-005453-4057qib7 1952 2 - - JJ cord-005453-4057qib7 1952 3 transplant transplant NN cord-005453-4057qib7 1952 4 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 1952 5 was be VBD cord-005453-4057qib7 1952 6 administered administer VBN cord-005453-4057qib7 1952 7 at at IN cord-005453-4057qib7 1952 8 100 100 CD cord-005453-4057qib7 1952 9 mg mg NNP cord-005453-4057qib7 1952 10 / / SYM cord-005453-4057qib7 1952 11 kg kg NN cord-005453-4057qib7 1952 12 at at IN cord-005453-4057qib7 1952 13 day day NN cord-005453-4057qib7 1952 14 +3 +3 NNP cord-005453-4057qib7 1952 15 , , , cord-005453-4057qib7 1952 16 +4 +4 NNP cord-005453-4057qib7 1952 17 , , , cord-005453-4057qib7 1952 18 and and CC cord-005453-4057qib7 1952 19 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 1952 20 15 15 CD cord-005453-4057qib7 1952 21 mg mg NNP cord-005453-4057qib7 1952 22 was be VBD cord-005453-4057qib7 1952 23 used use VBN cord-005453-4057qib7 1952 24 from from IN cord-005453-4057qib7 1952 25 D+5 D+5 NNP cord-005453-4057qib7 1952 26 till till IN cord-005453-4057qib7 1952 27 D+100 D+100 NNS cord-005453-4057qib7 1952 28 as as IN cord-005453-4057qib7 1952 29 graft graft NN cord-005453-4057qib7 1952 30 versus versus IN cord-005453-4057qib7 1952 31 host host NN cord-005453-4057qib7 1952 32 disease disease NN cord-005453-4057qib7 1952 33 prophylaxis prophylaxis NN cord-005453-4057qib7 1952 34 . . . cord-005453-4057qib7 1953 1 Results result NNS cord-005453-4057qib7 1953 2 : : : cord-005453-4057qib7 1954 1 Starting start VBG cord-005453-4057qib7 1954 2 D+1 d+1 NN cord-005453-4057qib7 1955 1 the the DT cord-005453-4057qib7 1955 2 patient patient NN cord-005453-4057qib7 1955 3 experienced experience VBD cord-005453-4057qib7 1955 4 eight eight CD cord-005453-4057qib7 1955 5 episodes episode NNS cord-005453-4057qib7 1955 6 of of IN cord-005453-4057qib7 1955 7 EBV EBV NNP cord-005453-4057qib7 1955 8 some some DT cord-005453-4057qib7 1955 9 of of IN cord-005453-4057qib7 1955 10 them -PRON- PRP cord-005453-4057qib7 1955 11 with with IN cord-005453-4057qib7 1955 12 severe severe JJ cord-005453-4057qib7 1955 13 blood blood NN cord-005453-4057qib7 1955 14 loss loss NN cord-005453-4057qib7 1955 15 . . . cord-005453-4057qib7 1956 1 To to TO cord-005453-4057qib7 1956 2 treat treat VB cord-005453-4057qib7 1956 3 the the DT cord-005453-4057qib7 1956 4 bleeding bleed VBG cord-005453-4057qib7 1956 5 episodes episode NNS cord-005453-4057qib7 1956 6 Blackmore Blackmore NNP cord-005453-4057qib7 1956 7 tube tube NN cord-005453-4057qib7 1956 8 was be VBD cord-005453-4057qib7 1956 9 placed place VBN cord-005453-4057qib7 1956 10 six six CD cord-005453-4057qib7 1956 11 times time NNS cord-005453-4057qib7 1956 12 with with IN cord-005453-4057qib7 1956 13 temporary temporary JJ cord-005453-4057qib7 1956 14 effect effect NN cord-005453-4057qib7 1956 15 . . . cord-005453-4057qib7 1957 1 To to TO cord-005453-4057qib7 1957 2 place place VB cord-005453-4057qib7 1957 3 Blackmore Blackmore NNP cord-005453-4057qib7 1957 4 tube tube VB cord-005453-4057qib7 1957 5 the the DT cord-005453-4057qib7 1957 6 patient patient NN cord-005453-4057qib7 1957 7 was be VBD cord-005453-4057qib7 1957 8 two two CD cord-005453-4057qib7 1957 9 times time NNS cord-005453-4057qib7 1957 10 intubated intubate VBN cord-005453-4057qib7 1957 11 and and CC cord-005453-4057qib7 1957 12 required require VBN cord-005453-4057qib7 1957 13 mechanical mechanical JJ cord-005453-4057qib7 1957 14 ventilation ventilation NN cord-005453-4057qib7 1957 15 . . . cord-005453-4057qib7 1958 1 At at IN cord-005453-4057qib7 1958 2 D+18 D+18 NNP cord-005453-4057qib7 1958 3 leukocyte leukocyte NN cord-005453-4057qib7 1958 4 and and CC cord-005453-4057qib7 1958 5 neutrophil neutrophil NN cord-005453-4057qib7 1958 6 engraftment engraftment NN cord-005453-4057qib7 1958 7 , , , cord-005453-4057qib7 1958 8 full full JJ cord-005453-4057qib7 1958 9 donor donor NN cord-005453-4057qib7 1958 10 chimerism chimerism NN cord-005453-4057qib7 1958 11 and and CC cord-005453-4057qib7 1958 12 molecular molecular JJ cord-005453-4057qib7 1958 13 remission remission NN cord-005453-4057qib7 1958 14 were be VBD cord-005453-4057qib7 1958 15 achieved achieve VBN cord-005453-4057qib7 1958 16 . . . cord-005453-4057qib7 1959 1 Platelet platelet NN cord-005453-4057qib7 1959 2 engraftment engraftment NN cord-005453-4057qib7 1959 3 was be VBD cord-005453-4057qib7 1959 4 documented document VBN cord-005453-4057qib7 1959 5 only only RB cord-005453-4057qib7 1959 6 at at IN cord-005453-4057qib7 1959 7 D D NNP cord-005453-4057qib7 1959 8 +42 +42 NNP cord-005453-4057qib7 1959 9 and and CC cord-005453-4057qib7 1959 10 poor poor JJ cord-005453-4057qib7 1959 11 graft graft NN cord-005453-4057qib7 1959 12 function function NN cord-005453-4057qib7 1959 13 was be VBD cord-005453-4057qib7 1959 14 present present JJ cord-005453-4057qib7 1959 15 due due IN cord-005453-4057qib7 1959 16 to to IN cord-005453-4057qib7 1959 17 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 1959 18 reactivation reactivation NN cord-005453-4057qib7 1959 19 ( ( -LRB- cord-005453-4057qib7 1959 20 D+41 D+41 NNP cord-005453-4057qib7 1959 21 ) ) -RRB- cord-005453-4057qib7 1959 22 and and CC cord-005453-4057qib7 1959 23 parvovirus parvovirus NN cord-005453-4057qib7 1959 24 B19 B19 NNP cord-005453-4057qib7 1959 25 reactivation reactivation NN cord-005453-4057qib7 1959 26 ( ( -LRB- cord-005453-4057qib7 1959 27 D+62 D+62 NNS cord-005453-4057qib7 1959 28 ) ) -RRB- cord-005453-4057qib7 1959 29 . . . cord-005453-4057qib7 1960 1 EVB EVB NNP cord-005453-4057qib7 1960 2 was be VBD cord-005453-4057qib7 1960 3 stopped stop VBN cord-005453-4057qib7 1960 4 at at IN cord-005453-4057qib7 1960 5 D+95 D+95 NNP cord-005453-4057qib7 1960 6 only only RB cord-005453-4057qib7 1960 7 after after IN cord-005453-4057qib7 1960 8 two two CD cord-005453-4057qib7 1960 9 esophageal esophageal JJ cord-005453-4057qib7 1960 10 veins vein NNS cord-005453-4057qib7 1960 11 ligations ligation NNS cord-005453-4057qib7 1960 12 , , , cord-005453-4057qib7 1960 13 and and CC cord-005453-4057qib7 1960 14 two two CD cord-005453-4057qib7 1960 15 procedures procedure NNS cord-005453-4057qib7 1960 16 of of IN cord-005453-4057qib7 1960 17 gastric gastric JJ cord-005453-4057qib7 1960 18 veins vein NNS cord-005453-4057qib7 1960 19 sclerotherapy sclerotherapy NN cord-005453-4057qib7 1960 20 . . . cord-005453-4057qib7 1961 1 Soon soon RB cord-005453-4057qib7 1961 2 ( ( -LRB- cord-005453-4057qib7 1961 3 D+111 D+111 NNS cord-005453-4057qib7 1961 4 ) ) -RRB- cord-005453-4057qib7 1962 1 the the DT cord-005453-4057qib7 1962 2 patient patient NN cord-005453-4057qib7 1962 3 achieved achieve VBD cord-005453-4057qib7 1962 4 complete complete JJ cord-005453-4057qib7 1962 5 platelet platelet NN cord-005453-4057qib7 1962 6 recovery recovery NN cord-005453-4057qib7 1962 7 ( ( -LRB- cord-005453-4057qib7 1962 8 more more JJR cord-005453-4057qib7 1962 9 than than IN cord-005453-4057qib7 1962 10 50x10 50x10 CD cord-005453-4057qib7 1962 11 9 9 CD cord-005453-4057qib7 1962 12 /l /l NN cord-005453-4057qib7 1962 13 ) ) -RRB- cord-005453-4057qib7 1962 14 and and CC cord-005453-4057qib7 1962 15 became become VBD cord-005453-4057qib7 1962 16 red red JJ cord-005453-4057qib7 1962 17 blood blood NN cord-005453-4057qib7 1962 18 cells cell NNS cord-005453-4057qib7 1962 19 transfusion transfusion NN cord-005453-4057qib7 1962 20 independent independent JJ cord-005453-4057qib7 1962 21 . . . cord-005453-4057qib7 1963 1 At at IN cord-005453-4057qib7 1963 2 day day NN cord-005453-4057qib7 1963 3 + + SYM cord-005453-4057qib7 1963 4 180 180 CD cord-005453-4057qib7 1963 5 complete complete JJ cord-005453-4057qib7 1963 6 remission remission NN cord-005453-4057qib7 1963 7 was be VBD cord-005453-4057qib7 1963 8 confirmed confirm VBN cord-005453-4057qib7 1963 9 by by IN cord-005453-4057qib7 1963 10 splenomegaly splenomegaly NN cord-005453-4057qib7 1963 11 resolution resolution NN cord-005453-4057qib7 1963 12 , , , cord-005453-4057qib7 1963 13 regression regression NN cord-005453-4057qib7 1963 14 of of IN cord-005453-4057qib7 1963 15 bone bone NN cord-005453-4057qib7 1963 16 marrow marrow NN cord-005453-4057qib7 1963 17 fibrosis fibrosis NN cord-005453-4057qib7 1963 18 , , , cord-005453-4057qib7 1963 19 full full JJ cord-005453-4057qib7 1963 20 donor donor NN cord-005453-4057qib7 1963 21 chimerism chimerism NN cord-005453-4057qib7 1963 22 , , , cord-005453-4057qib7 1963 23 JAK2V617F jak2v617f JJ cord-005453-4057qib7 1963 24 - - HYPH cord-005453-4057qib7 1963 25 negative negative JJ cord-005453-4057qib7 1963 26 molecular molecular JJ cord-005453-4057qib7 1963 27 status status NN cord-005453-4057qib7 1963 28 . . . cord-005453-4057qib7 1964 1 CBC CBC NNP cord-005453-4057qib7 1964 2 showed show VBD cord-005453-4057qib7 1964 3 Hb Hb NNP cord-005453-4057qib7 1964 4 130 130 CD cord-005453-4057qib7 1964 5 g g NN cord-005453-4057qib7 1964 6 / / SYM cord-005453-4057qib7 1964 7 l l NN cord-005453-4057qib7 1964 8 , , , cord-005453-4057qib7 1964 9 platelets platelet NNS cord-005453-4057qib7 1964 10 73x10 73x10 CD cord-005453-4057qib7 1964 11 9 9 CD cord-005453-4057qib7 1964 12 /l /l NNP cord-005453-4057qib7 1964 13 , , , cord-005453-4057qib7 1964 14 leucocytes leucocytes NNP cord-005453-4057qib7 1964 15 3,8x10 3,8x10 NNP cord-005453-4057qib7 1964 16 9 9 CD cord-005453-4057qib7 1964 17 /l /l NNP cord-005453-4057qib7 1964 18 . . . cord-005453-4057qib7 1965 1 Ultrasound ultrasound NN cord-005453-4057qib7 1965 2 examination examination NN cord-005453-4057qib7 1965 3 after after IN cord-005453-4057qib7 1965 4 transplant transplant NN cord-005453-4057qib7 1965 5 documented document VBD cord-005453-4057qib7 1965 6 portal portal JJ cord-005453-4057qib7 1965 7 vein vein NN cord-005453-4057qib7 1965 8 thrombosis thrombosis NN cord-005453-4057qib7 1965 9 recanalization recanalization NN cord-005453-4057qib7 1965 10 . . . cord-005453-4057qib7 1966 1 At at IN cord-005453-4057qib7 1966 2 day day NN cord-005453-4057qib7 1966 3 + + CC cord-005453-4057qib7 1966 4 180 180 CD cord-005453-4057qib7 1966 5 she -PRON- PRP cord-005453-4057qib7 1966 6 developed develop VBD cord-005453-4057qib7 1966 7 mild mild JJ cord-005453-4057qib7 1966 8 ( ( -LRB- cord-005453-4057qib7 1966 9 NIH NIH NNP cord-005453-4057qib7 1966 10 ) ) -RRB- cord-005453-4057qib7 1966 11 chronic chronic JJ cord-005453-4057qib7 1966 12 graft graft NN cord-005453-4057qib7 1966 13 versus versus IN cord-005453-4057qib7 1966 14 host host NN cord-005453-4057qib7 1966 15 disease disease NN cord-005453-4057qib7 1966 16 with with IN cord-005453-4057qib7 1966 17 eyes eye NNS cord-005453-4057qib7 1966 18 and and CC cord-005453-4057qib7 1966 19 mouth mouth NN cord-005453-4057qib7 1966 20 involvement involvement NN cord-005453-4057qib7 1966 21 , , , cord-005453-4057qib7 1966 22 which which WDT cord-005453-4057qib7 1966 23 was be VBD cord-005453-4057qib7 1966 24 managed manage VBN cord-005453-4057qib7 1966 25 with with IN cord-005453-4057qib7 1966 26 topical topical JJ cord-005453-4057qib7 1966 27 steroids steroid NNS cord-005453-4057qib7 1966 28 . . . cord-005453-4057qib7 1967 1 At at IN cord-005453-4057qib7 1967 2 D+958 d+958 NN cord-005453-4057qib7 1967 3 after after IN cord-005453-4057qib7 1967 4 transplant transplant NN cord-005453-4057qib7 1967 5 the the DT cord-005453-4057qib7 1967 6 patient patient NN cord-005453-4057qib7 1967 7 is be VBZ cord-005453-4057qib7 1967 8 alive alive JJ cord-005453-4057qib7 1967 9 in in IN cord-005453-4057qib7 1967 10 complete complete JJ cord-005453-4057qib7 1967 11 remission remission NN cord-005453-4057qib7 1967 12 and and CC cord-005453-4057qib7 1967 13 has have VBZ cord-005453-4057qib7 1967 14 no no DT cord-005453-4057qib7 1967 15 recurrent recurrent JJ cord-005453-4057qib7 1967 16 bleedings bleeding NNS cord-005453-4057qib7 1967 17 . . . cord-005453-4057qib7 1968 1 Conclusions conclusion NNS cord-005453-4057qib7 1968 2 : : : cord-005453-4057qib7 1969 1 Splanchnic splanchnic JJ cord-005453-4057qib7 1969 2 vein vein NN cord-005453-4057qib7 1969 3 thrombosis thrombosis NN cord-005453-4057qib7 1969 4 can can MD cord-005453-4057qib7 1969 5 significantly significantly RB cord-005453-4057qib7 1969 6 complicate complicate VB cord-005453-4057qib7 1969 7 the the DT cord-005453-4057qib7 1969 8 course course NN cord-005453-4057qib7 1969 9 of of IN cord-005453-4057qib7 1969 10 alloHSCT alloHSCT NNP cord-005453-4057qib7 1969 11 in in IN cord-005453-4057qib7 1969 12 PMF PMF NNP cord-005453-4057qib7 1969 13 . . . cord-005453-4057qib7 1970 1 Easy easy JJ cord-005453-4057qib7 1970 2 access access NN cord-005453-4057qib7 1970 3 to to IN cord-005453-4057qib7 1970 4 surgical surgical JJ cord-005453-4057qib7 1970 5 , , , cord-005453-4057qib7 1970 6 intensive intensive JJ cord-005453-4057qib7 1970 7 care care NN cord-005453-4057qib7 1970 8 unit unit NN cord-005453-4057qib7 1970 9 and and CC cord-005453-4057qib7 1970 10 endoscopic endoscopic NN cord-005453-4057qib7 1970 11 teams team NNS cord-005453-4057qib7 1970 12 is be VBZ cord-005453-4057qib7 1970 13 required require VBN cord-005453-4057qib7 1970 14 to to TO cord-005453-4057qib7 1970 15 make make VB cord-005453-4057qib7 1970 16 alloHSCT alloHSCT NNP cord-005453-4057qib7 1970 17 more more RBR cord-005453-4057qib7 1970 18 feasible feasible JJ cord-005453-4057qib7 1970 19 in in IN cord-005453-4057qib7 1970 20 this this DT cord-005453-4057qib7 1970 21 group group NN cord-005453-4057qib7 1970 22 of of IN cord-005453-4057qib7 1970 23 patients patient NNS cord-005453-4057qib7 1970 24 . . . cord-005453-4057qib7 1971 1 Disclosure disclosure NN cord-005453-4057qib7 1971 2 All all DT cord-005453-4057qib7 1971 3 patients patient NNS cord-005453-4057qib7 1971 4 received receive VBD cord-005453-4057qib7 1971 5 Treosulfan Treosulfan NNP cord-005453-4057qib7 1971 6 - - HYPH cord-005453-4057qib7 1971 7 based base VBN cord-005453-4057qib7 1971 8 MAC MAC NNP cord-005453-4057qib7 1971 9 regimens regimen NNS cord-005453-4057qib7 1971 10 , , , cord-005453-4057qib7 1971 11 Treosulfan(Total Treosulfan(Total NNP cord-005453-4057qib7 1971 12 dose dose NN cord-005453-4057qib7 1971 13 , , , cord-005453-4057qib7 1971 14 36 36 CD cord-005453-4057qib7 1971 15 - - SYM cord-005453-4057qib7 1971 16 42gms 42gms CD cord-005453-4057qib7 1971 17 / / SYM cord-005453-4057qib7 1971 18 m2 m2 NNP cord-005453-4057qib7 1971 19 ) ) -RRB- cord-005453-4057qib7 1971 20 was be VBD cord-005453-4057qib7 1971 21 given give VBN cord-005453-4057qib7 1971 22 in in IN cord-005453-4057qib7 1971 23 combination combination NN cord-005453-4057qib7 1971 24 with with IN cord-005453-4057qib7 1971 25 different different JJ cord-005453-4057qib7 1971 26 conditioning conditioning NN cord-005453-4057qib7 1971 27 drugs drug NNS cord-005453-4057qib7 1971 28 . . . cord-005453-4057qib7 1972 1 The the DT cord-005453-4057qib7 1972 2 most most RBS cord-005453-4057qib7 1972 3 commonly commonly RB cord-005453-4057qib7 1972 4 used use VBN cord-005453-4057qib7 1972 5 regimen regimen NN cord-005453-4057qib7 1972 6 was be VBD cord-005453-4057qib7 1972 7 Treosulfan Treosulfan NNP cord-005453-4057qib7 1972 8 , , , cord-005453-4057qib7 1972 9 Fludarabine Fludarabine NNP cord-005453-4057qib7 1972 10 ( ( -LRB- cord-005453-4057qib7 1972 11 150mgs 150mgs CD cord-005453-4057qib7 1972 12 / / SYM cord-005453-4057qib7 1972 13 m2 m2 NNP cord-005453-4057qib7 1972 14 ) ) -RRB- cord-005453-4057qib7 1972 15 and and CC cord-005453-4057qib7 1972 16 Thiotepa(10mgs Thiotepa(10mgs NNP cord-005453-4057qib7 1972 17 / / SYM cord-005453-4057qib7 1972 18 kg kg NN cord-005453-4057qib7 1972 19 ) ) -RRB- cord-005453-4057qib7 1972 20 referred refer VBD cord-005453-4057qib7 1972 21 to to IN cord-005453-4057qib7 1972 22 as as IN cord-005453-4057qib7 1972 23 FTT FTT NNP cord-005453-4057qib7 1972 24 that that WDT cord-005453-4057qib7 1972 25 was be VBD cord-005453-4057qib7 1972 26 used use VBN cord-005453-4057qib7 1972 27 in in IN cord-005453-4057qib7 1972 28 59%(n=55 59%(n=55 CD cord-005453-4057qib7 1972 29 ) ) -RRB- cord-005453-4057qib7 1972 30 . . . cord-005453-4057qib7 1973 1 Serotherapy Serotherapy NNP cord-005453-4057qib7 1973 2 was be VBD cord-005453-4057qib7 1973 3 given give VBN cord-005453-4057qib7 1973 4 in in IN cord-005453-4057qib7 1973 5 93 93 CD cord-005453-4057qib7 1973 6 % % NN cord-005453-4057qib7 1973 7 of of IN cord-005453-4057qib7 1973 8 patients(n=87 patients(n=87 NN cord-005453-4057qib7 1973 9 ) ) -RRB- cord-005453-4057qib7 1973 10 , , , cord-005453-4057qib7 1973 11 as as IN cord-005453-4057qib7 1973 12 either either CC cord-005453-4057qib7 1973 13 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 1973 14 or or CC cord-005453-4057qib7 1973 15 Antithymocyte Antithymocyte NNP cord-005453-4057qib7 1973 16 globulin globulin NN cord-005453-4057qib7 1973 17 in in IN cord-005453-4057qib7 1973 18 82%(n=77 82%(n=77 CD cord-005453-4057qib7 1973 19 ) ) -RRB- cord-005453-4057qib7 1973 20 and and CC cord-005453-4057qib7 1973 21 11%(n=10 11%(n=10 CD cord-005453-4057qib7 1973 22 ) ) -RRB- cord-005453-4057qib7 1973 23 , , , cord-005453-4057qib7 1973 24 respectively respectively RB cord-005453-4057qib7 1973 25 . . . cord-005453-4057qib7 1974 1 post post JJ cord-005453-4057qib7 1974 2 - - JJ cord-005453-4057qib7 1974 3 transplant transplant JJ cord-005453-4057qib7 1974 4 Graft graft NN cord-005453-4057qib7 1974 5 - - HYPH cord-005453-4057qib7 1974 6 versus versus IN cord-005453-4057qib7 1974 7 - - HYPH cord-005453-4057qib7 1974 8 Host host NN cord-005453-4057qib7 1974 9 disease disease NN cord-005453-4057qib7 1974 10 ( ( -LRB- cord-005453-4057qib7 1974 11 GVHD GVHD NNP cord-005453-4057qib7 1974 12 ) ) -RRB- cord-005453-4057qib7 1974 13 prophylaxis prophylaxis NN cord-005453-4057qib7 1974 14 was be VBD cord-005453-4057qib7 1974 15 given give VBN cord-005453-4057qib7 1974 16 in in IN cord-005453-4057qib7 1974 17 all all DT cord-005453-4057qib7 1974 18 patients patient NNS cord-005453-4057qib7 1974 19 , , , cord-005453-4057qib7 1974 20 based base VBN cord-005453-4057qib7 1974 21 mostly mostly RB cord-005453-4057qib7 1974 22 on on IN cord-005453-4057qib7 1974 23 ciclosporin ciclosporin NN cord-005453-4057qib7 1974 24 . . . cord-005453-4057qib7 1975 1 46 46 CD cord-005453-4057qib7 1975 2 patients(49 patients(49 NNP cord-005453-4057qib7 1975 3 % % NN cord-005453-4057qib7 1975 4 ) ) -RRB- cord-005453-4057qib7 1975 5 received receive VBD cord-005453-4057qib7 1975 6 the the DT cord-005453-4057qib7 1975 7 transplant transplant NN cord-005453-4057qib7 1975 8 from from IN cord-005453-4057qib7 1975 9 identicalrelated identicalrelate VBN cord-005453-4057qib7 1975 10 donors donor NNS cord-005453-4057qib7 1975 11 , , , cord-005453-4057qib7 1975 12 46 46 CD cord-005453-4057qib7 1975 13 patients(49 patients(49 NNP cord-005453-4057qib7 1975 14 % % NN cord-005453-4057qib7 1975 15 ) ) -RRB- cord-005453-4057qib7 1975 16 received receive VBD cord-005453-4057qib7 1975 17 the the DT cord-005453-4057qib7 1975 18 transplant transplant NN cord-005453-4057qib7 1975 19 from from IN cord-005453-4057qib7 1975 20 matched match VBN cord-005453-4057qib7 1975 21 - - HYPH cord-005453-4057qib7 1975 22 unrelated unrelated JJ cord-005453-4057qib7 1975 23 donors donor NNS cord-005453-4057qib7 1975 24 , , , cord-005453-4057qib7 1975 25 and and CC cord-005453-4057qib7 1975 26 two two CD cord-005453-4057qib7 1975 27 patients(2 patients(2 NN cord-005453-4057qib7 1975 28 % % NN cord-005453-4057qib7 1975 29 ) ) -RRB- cord-005453-4057qib7 1975 30 had have VBD cord-005453-4057qib7 1975 31 haploidentical haploidentical JJ cord-005453-4057qib7 1975 32 transplants transplant NNS cord-005453-4057qib7 1975 33 . . . cord-005453-4057qib7 1976 1 90 90 CD cord-005453-4057qib7 1976 2 % % NN cord-005453-4057qib7 1976 3 of of IN cord-005453-4057qib7 1976 4 the the DT cord-005453-4057qib7 1976 5 patients(n=85 patients(n=85 NNS cord-005453-4057qib7 1976 6 ) ) -RRB- cord-005453-4057qib7 1976 7 were be VBD cord-005453-4057qib7 1976 8 fully fully RB cord-005453-4057qib7 1976 9 HLA HLA NNP cord-005453-4057qib7 1976 10 - - HYPH cord-005453-4057qib7 1976 11 matched match VBN cord-005453-4057qib7 1976 12 . . . cord-005453-4057qib7 1977 1 All all DT cord-005453-4057qib7 1977 2 stem stem VBP cord-005453-4057qib7 1977 3 cell cell NN cord-005453-4057qib7 1977 4 sources source NNS cord-005453-4057qib7 1977 5 were be VBD cord-005453-4057qib7 1977 6 used use VBN cord-005453-4057qib7 1977 7 as as IN cord-005453-4057qib7 1977 8 bone bone NN cord-005453-4057qib7 1977 9 marrow marrow NN cord-005453-4057qib7 1977 10 in in IN cord-005453-4057qib7 1977 11 59%(n=55 59%(n=55 CD cord-005453-4057qib7 1977 12 ) ) -RRB- cord-005453-4057qib7 1977 13 , , , cord-005453-4057qib7 1977 14 peripheral peripheral JJ cord-005453-4057qib7 1977 15 blood blood NN cord-005453-4057qib7 1977 16 stem stem NN cord-005453-4057qib7 1977 17 cells cell NNS cord-005453-4057qib7 1977 18 in in IN cord-005453-4057qib7 1977 19 33%(n=31 33%(n=31 CD cord-005453-4057qib7 1977 20 ) ) -RRB- cord-005453-4057qib7 1977 21 , , , cord-005453-4057qib7 1977 22 and and CC cord-005453-4057qib7 1977 23 umbilical umbilical JJ cord-005453-4057qib7 1977 24 cord cord NN cord-005453-4057qib7 1977 25 blood blood NN cord-005453-4057qib7 1977 26 in in IN cord-005453-4057qib7 1977 27 8%(n=8 8%(n=8 CD cord-005453-4057qib7 1977 28 ) ) -RRB- cord-005453-4057qib7 1977 29 . . . cord-005453-4057qib7 1978 1 This this DT cord-005453-4057qib7 1978 2 Treosulfan Treosulfan NNP cord-005453-4057qib7 1978 3 - - HYPH cord-005453-4057qib7 1978 4 based base VBN cord-005453-4057qib7 1978 5 conditioning conditioning NN cord-005453-4057qib7 1978 6 was be VBD cord-005453-4057qib7 1978 7 given give VBN cord-005453-4057qib7 1978 8 as as IN cord-005453-4057qib7 1978 9 the the DT cord-005453-4057qib7 1978 10 1 1 CD cord-005453-4057qib7 1978 11 st st NNP cord-005453-4057qib7 1978 12 transplant transplant NN cord-005453-4057qib7 1978 13 in in IN cord-005453-4057qib7 1978 14 92%(n=85 92%(n=85 CD cord-005453-4057qib7 1978 15 ) ) -RRB- cord-005453-4057qib7 1978 16 , , , cord-005453-4057qib7 1978 17 and and CC cord-005453-4057qib7 1978 18 as as IN cord-005453-4057qib7 1978 19 the the DT cord-005453-4057qib7 1978 20 2 2 CD cord-005453-4057qib7 1978 21 nd nd NNP cord-005453-4057qib7 1978 22 transplant transplant NN cord-005453-4057qib7 1978 23 after after IN cord-005453-4057qib7 1978 24 the the DT cord-005453-4057qib7 1978 25 failure failure NN cord-005453-4057qib7 1978 26 of of IN cord-005453-4057qib7 1978 27 a a DT cord-005453-4057qib7 1978 28 first first JJ cord-005453-4057qib7 1978 29 procedure procedure NN cord-005453-4057qib7 1978 30 in in IN cord-005453-4057qib7 1978 31 8%(n=9 8%(n=9 CD cord-005453-4057qib7 1978 32 ) ) -RRB- cord-005453-4057qib7 1978 33 . . . cord-005453-4057qib7 1979 1 Two two CD cord-005453-4057qib7 1979 2 patients patient NNS cord-005453-4057qib7 1979 3 received receive VBD cord-005453-4057qib7 1979 4 Treosulfan Treosulfan NNP cord-005453-4057qib7 1979 5 - - HYPH cord-005453-4057qib7 1979 6 based base VBN cord-005453-4057qib7 1979 7 conditioned conditioned JJ cord-005453-4057qib7 1979 8 transplant transplant NN cord-005453-4057qib7 1979 9 twice twice RB cord-005453-4057qib7 1979 10 . . . cord-005453-4057qib7 1980 1 Results result NNS cord-005453-4057qib7 1980 2 : : : cord-005453-4057qib7 1981 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 1981 2 engraftment engraftment NN cord-005453-4057qib7 1981 3 and and CC cord-005453-4057qib7 1981 4 platelet platelet NN cord-005453-4057qib7 1981 5 engraftment engraftment NN cord-005453-4057qib7 1981 6 occurred occur VBD cord-005453-4057qib7 1981 7 at at IN cord-005453-4057qib7 1981 8 a a DT cord-005453-4057qib7 1981 9 median median NN cord-005453-4057qib7 1981 10 of of IN cord-005453-4057qib7 1981 11 13 13 CD cord-005453-4057qib7 1981 12 days day NNS cord-005453-4057qib7 1981 13 and and CC cord-005453-4057qib7 1981 14 18 18 CD cord-005453-4057qib7 1981 15 days day NNS cord-005453-4057qib7 1981 16 respectively respectively RB cord-005453-4057qib7 1981 17 . . . cord-005453-4057qib7 1982 1 Chimerism chimerism NN cord-005453-4057qib7 1982 2 was be VBD cord-005453-4057qib7 1982 3 full full JJ cord-005453-4057qib7 1982 4 donor donor NN cord-005453-4057qib7 1982 5 in in IN cord-005453-4057qib7 1982 6 55%(n=52 55%(n=52 CD cord-005453-4057qib7 1982 7 ) ) -RRB- cord-005453-4057qib7 1982 8 , , , cord-005453-4057qib7 1982 9 high high JJ cord-005453-4057qib7 1982 10 donor donor NN cord-005453-4057qib7 1982 11 in in IN cord-005453-4057qib7 1982 12 18%(n=17 18%(n=17 CD cord-005453-4057qib7 1982 13 ) ) -RRB- cord-005453-4057qib7 1982 14 , , , cord-005453-4057qib7 1982 15 and and CC cord-005453-4057qib7 1982 16 mixed mixed JJ cord-005453-4057qib7 1982 17 donor donor NN cord-005453-4057qib7 1982 18 in in IN cord-005453-4057qib7 1982 19 9%(n=8 9%(n=8 CD cord-005453-4057qib7 1982 20 ) ) -RRB- cord-005453-4057qib7 1982 21 . . . cord-005453-4057qib7 1983 1 GVHD GVHD NNP cord-005453-4057qib7 1983 2 developed develop VBD cord-005453-4057qib7 1983 3 in in IN cord-005453-4057qib7 1983 4 43 43 CD cord-005453-4057qib7 1983 5 % % NN cord-005453-4057qib7 1983 6 of of IN cord-005453-4057qib7 1983 7 patients(n=40 patients(n=40 NNP cord-005453-4057qib7 1983 8 ) ) -RRB- cord-005453-4057qib7 1983 9 , , , cord-005453-4057qib7 1983 10 with with IN cord-005453-4057qib7 1983 11 acute acute JJ cord-005453-4057qib7 1983 12 GVHD GVHD NNP cord-005453-4057qib7 1983 13 grade grade NN cord-005453-4057qib7 1983 14 I I NNP cord-005453-4057qib7 1983 15 / / SYM cord-005453-4057qib7 1983 16 II II NNP cord-005453-4057qib7 1983 17 and and CC cord-005453-4057qib7 1983 18 grade grade NN cord-005453-4057qib7 1983 19 III III NNP cord-005453-4057qib7 1983 20 / / SYM cord-005453-4057qib7 1983 21 IV IV NNP cord-005453-4057qib7 1983 22 developed develop VBD cord-005453-4057qib7 1983 23 in in IN cord-005453-4057qib7 1983 24 29%(n=27 29%(n=27 CD cord-005453-4057qib7 1983 25 ) ) -RRB- cord-005453-4057qib7 1983 26 and and CC cord-005453-4057qib7 1983 27 2%(n=2 2%(n=2 CD cord-005453-4057qib7 1983 28 ) ) -RRB- cord-005453-4057qib7 1983 29 , , , cord-005453-4057qib7 1983 30 respectively respectively RB cord-005453-4057qib7 1983 31 . . . cord-005453-4057qib7 1984 1 Chronic chronic JJ cord-005453-4057qib7 1984 2 GVHD GVHD NNP cord-005453-4057qib7 1984 3 grade grade NN cord-005453-4057qib7 1984 4 I I NNP cord-005453-4057qib7 1984 5 / / SYM cord-005453-4057qib7 1984 6 II II NNP cord-005453-4057qib7 1984 7 and and CC cord-005453-4057qib7 1984 8 grade grade NN cord-005453-4057qib7 1984 9 III III NNP cord-005453-4057qib7 1984 10 / / SYM cord-005453-4057qib7 1984 11 IV IV NNP cord-005453-4057qib7 1984 12 developed develop VBD cord-005453-4057qib7 1984 13 in in IN cord-005453-4057qib7 1984 14 13%(n=12 13%(n=12 CD cord-005453-4057qib7 1984 15 ) ) -RRB- cord-005453-4057qib7 1984 16 and and CC cord-005453-4057qib7 1984 17 2%(n=2 2%(n=2 CD cord-005453-4057qib7 1984 18 ) ) -RRB- cord-005453-4057qib7 1984 19 , , , cord-005453-4057qib7 1984 20 respectively respectively RB cord-005453-4057qib7 1984 21 . . . cord-005453-4057qib7 1985 1 All all DT cord-005453-4057qib7 1985 2 chronic chronic JJ cord-005453-4057qib7 1985 3 GVHD GVHD NNP cord-005453-4057qib7 1985 4 were be VBD cord-005453-4057qib7 1985 5 mild mild JJ cord-005453-4057qib7 1985 6 , , , cord-005453-4057qib7 1985 7 limited limited JJ cord-005453-4057qib7 1985 8 , , , cord-005453-4057qib7 1985 9 non non JJ cord-005453-4057qib7 1985 10 - - JJ cord-005453-4057qib7 1985 11 extensive extensive JJ cord-005453-4057qib7 1985 12 , , , cord-005453-4057qib7 1985 13 and and CC cord-005453-4057qib7 1985 14 resolved resolve VBD cord-005453-4057qib7 1985 15 completely completely RB cord-005453-4057qib7 1985 16 . . . cord-005453-4057qib7 1986 1 None none NN cord-005453-4057qib7 1986 2 of of IN cord-005453-4057qib7 1986 3 our -PRON- PRP$ cord-005453-4057qib7 1986 4 patients patient NNS cord-005453-4057qib7 1986 5 had have VBD cord-005453-4057qib7 1986 6 persistent persistent JJ cord-005453-4057qib7 1986 7 GVHD GVHD NNP cord-005453-4057qib7 1986 8 necessitating necessitate VBG cord-005453-4057qib7 1986 9 long long JJ cord-005453-4057qib7 1986 10 - - HYPH cord-005453-4057qib7 1986 11 term term NN cord-005453-4057qib7 1986 12 systemic systemic JJ cord-005453-4057qib7 1986 13 immunosuppression immunosuppression NN cord-005453-4057qib7 1986 14 . . . cord-005453-4057qib7 1987 1 Mild mild JJ cord-005453-4057qib7 1987 2 VOD VOD NNP cord-005453-4057qib7 1987 3 occurred occur VBD cord-005453-4057qib7 1987 4 in in IN cord-005453-4057qib7 1987 5 13%(n=12 13%(n=12 CD cord-005453-4057qib7 1987 6 ) ) -RRB- cord-005453-4057qib7 1987 7 , , , cord-005453-4057qib7 1987 8 and and CC cord-005453-4057qib7 1987 9 severe severe JJ cord-005453-4057qib7 1987 10 VOD vod NN cord-005453-4057qib7 1987 11 occurred occur VBD cord-005453-4057qib7 1987 12 in in IN cord-005453-4057qib7 1987 13 2%(n=2 2%(n=2 CD cord-005453-4057qib7 1987 14 ) ) -RRB- cord-005453-4057qib7 1987 15 . . . cord-005453-4057qib7 1988 1 One one CD cord-005453-4057qib7 1988 2 of of IN cord-005453-4057qib7 1988 3 them -PRON- PRP cord-005453-4057qib7 1988 4 died die VBD cord-005453-4057qib7 1988 5 but but CC cord-005453-4057qib7 1988 6 was be VBD cord-005453-4057qib7 1988 7 believed believe VBN cord-005453-4057qib7 1988 8 to to TO cord-005453-4057qib7 1988 9 be be VB cord-005453-4057qib7 1988 10 related relate VBN cord-005453-4057qib7 1988 11 to to IN cord-005453-4057qib7 1988 12 the the DT cord-005453-4057qib7 1988 13 underlying underlie VBG cord-005453-4057qib7 1988 14 disease disease NN cord-005453-4057qib7 1988 15 ( ( -LRB- cord-005453-4057qib7 1988 16 Wolman Wolman NNP cord-005453-4057qib7 1988 17 Syndrome Syndrome NNP cord-005453-4057qib7 1988 18 ) ) -RRB- cord-005453-4057qib7 1988 19 . . . cord-005453-4057qib7 1989 1 Viral viral JJ cord-005453-4057qib7 1989 2 reactivation reactivation NN cord-005453-4057qib7 1989 3 occurred occur VBD cord-005453-4057qib7 1989 4 in in IN cord-005453-4057qib7 1989 5 55 55 CD cord-005453-4057qib7 1989 6 % % NN cord-005453-4057qib7 1989 7 of of IN cord-005453-4057qib7 1989 8 patients(n=52 patients(n=52 NN cord-005453-4057qib7 1989 9 ) ) -RRB- cord-005453-4057qib7 1989 10 , , , cord-005453-4057qib7 1989 11 with with IN cord-005453-4057qib7 1989 12 CMV CMV NNP cord-005453-4057qib7 1989 13 , , , cord-005453-4057qib7 1989 14 EBV EBV NNP cord-005453-4057qib7 1989 15 , , , cord-005453-4057qib7 1989 16 and and CC cord-005453-4057qib7 1989 17 Adenovirus Adenovirus NNP cord-005453-4057qib7 1989 18 reactivation reactivation NN cord-005453-4057qib7 1989 19 was be VBD cord-005453-4057qib7 1989 20 found find VBN cord-005453-4057qib7 1989 21 in in IN cord-005453-4057qib7 1989 22 34 34 CD cord-005453-4057qib7 1989 23 % % NN cord-005453-4057qib7 1989 24 , , , cord-005453-4057qib7 1989 25 21 21 CD cord-005453-4057qib7 1989 26 % % NN cord-005453-4057qib7 1989 27 , , , cord-005453-4057qib7 1989 28 and and CC cord-005453-4057qib7 1989 29 14 14 CD cord-005453-4057qib7 1989 30 % % NN cord-005453-4057qib7 1989 31 , , , cord-005453-4057qib7 1989 32 respectively respectively RB cord-005453-4057qib7 1989 33 . . . cord-005453-4057qib7 1990 1 Five five CD cord-005453-4057qib7 1990 2 patients patient NNS cord-005453-4057qib7 1990 3 had have VBD cord-005453-4057qib7 1990 4 invasive invasive JJ cord-005453-4057qib7 1990 5 adenoviraemia adenoviraemia NN cord-005453-4057qib7 1990 6 that that WDT cord-005453-4057qib7 1990 7 contributed contribute VBD cord-005453-4057qib7 1990 8 to to IN cord-005453-4057qib7 1990 9 death death NN cord-005453-4057qib7 1990 10 in in IN cord-005453-4057qib7 1990 11 two two CD cord-005453-4057qib7 1990 12 of of IN cord-005453-4057qib7 1990 13 them -PRON- PRP cord-005453-4057qib7 1990 14 . . . cord-005453-4057qib7 1991 1 Primary primary JJ cord-005453-4057qib7 1991 2 graft graft NN cord-005453-4057qib7 1991 3 failure failure NN cord-005453-4057qib7 1991 4 happened happen VBD cord-005453-4057qib7 1991 5 in in IN cord-005453-4057qib7 1991 6 two two CD cord-005453-4057qib7 1991 7 patients(2 patients(2 NN cord-005453-4057qib7 1991 8 % % NN cord-005453-4057qib7 1991 9 ) ) -RRB- cord-005453-4057qib7 1991 10 due due IN cord-005453-4057qib7 1991 11 to to IN cord-005453-4057qib7 1991 12 adenoviraemia adenoviraemia NNP cord-005453-4057qib7 1991 13 . . . cord-005453-4057qib7 1992 1 Seven seven CD cord-005453-4057qib7 1992 2 patients(7 patients(7 JJ cord-005453-4057qib7 1992 3 % % NN cord-005453-4057qib7 1992 4 ) ) -RRB- cord-005453-4057qib7 1992 5 had have VBD cord-005453-4057qib7 1992 6 secondary secondary JJ cord-005453-4057qib7 1992 7 graft graft NN cord-005453-4057qib7 1992 8 failure failure NN cord-005453-4057qib7 1992 9 with with IN cord-005453-4057qib7 1992 10 autologous autologous JJ cord-005453-4057qib7 1992 11 reconstitution reconstitution NN cord-005453-4057qib7 1992 12 . . . cord-005453-4057qib7 1993 1 Graft graft NN cord-005453-4057qib7 1993 2 failure failure NN cord-005453-4057qib7 1993 3 was be VBD cord-005453-4057qib7 1993 4 significantly significantly RB cord-005453-4057qib7 1993 5 lower low JJR cord-005453-4057qib7 1993 6 ( ( -LRB- cord-005453-4057qib7 1993 7 P0.045 p0.045 NN cord-005453-4057qib7 1993 8 ) ) -RRB- cord-005453-4057qib7 1993 9 in in IN cord-005453-4057qib7 1993 10 the the DT cord-005453-4057qib7 1993 11 FTT FTT NNP cord-005453-4057qib7 1993 12 group group NN cord-005453-4057qib7 1993 13 than than IN cord-005453-4057qib7 1993 14 other other JJ cord-005453-4057qib7 1993 15 conditioning conditioning NN cord-005453-4057qib7 1993 16 groups group NNS cord-005453-4057qib7 1993 17 . . . cord-005453-4057qib7 1994 1 At at IN cord-005453-4057qib7 1994 2 a a DT cord-005453-4057qib7 1994 3 median median JJ cord-005453-4057qib7 1994 4 follow follow NN cord-005453-4057qib7 1994 5 - - HYPH cord-005453-4057qib7 1994 6 up up NN cord-005453-4057qib7 1994 7 of of IN cord-005453-4057qib7 1994 8 35 35 CD cord-005453-4057qib7 1994 9 months month NNS cord-005453-4057qib7 1994 10 ( ( -LRB- cord-005453-4057qib7 1994 11 Range range NN cord-005453-4057qib7 1994 12 , , , cord-005453-4057qib7 1994 13 two-174 two-174 NNP cord-005453-4057qib7 1994 14 months month NNS cord-005453-4057qib7 1994 15 ) ) -RRB- cord-005453-4057qib7 1994 16 , , , cord-005453-4057qib7 1994 17 eleven eleven CD cord-005453-4057qib7 1994 18 patients(11.9 patients(11.9 NN cord-005453-4057qib7 1994 19 % % NN cord-005453-4057qib7 1994 20 ) ) -RRB- cord-005453-4057qib7 1994 21 died die VBD cord-005453-4057qib7 1994 22 , , , cord-005453-4057qib7 1994 23 with with IN cord-005453-4057qib7 1994 24 Overall overall JJ cord-005453-4057qib7 1994 25 survival survival NN cord-005453-4057qib7 1994 26 of of IN cord-005453-4057qib7 1994 27 88.1 88.1 CD cord-005453-4057qib7 1994 28 % % NN cord-005453-4057qib7 1994 29 , , , cord-005453-4057qib7 1994 30 and and CC cord-005453-4057qib7 1994 31 event event NN cord-005453-4057qib7 1994 32 - - HYPH cord-005453-4057qib7 1994 33 free free JJ cord-005453-4057qib7 1994 34 survival survival NN cord-005453-4057qib7 1994 35 of of IN cord-005453-4057qib7 1994 36 80.9 80.9 CD cord-005453-4057qib7 1994 37 % % NN cord-005453-4057qib7 1994 38 . . . cord-005453-4057qib7 1995 1 Five five CD cord-005453-4057qib7 1995 2 patients patient NNS cord-005453-4057qib7 1995 3 died die VBD cord-005453-4057qib7 1995 4 due due IN cord-005453-4057qib7 1995 5 to to IN cord-005453-4057qib7 1995 6 complications complication NNS cord-005453-4057qib7 1995 7 related relate VBN cord-005453-4057qib7 1995 8 to to IN cord-005453-4057qib7 1995 9 their -PRON- PRP$ cord-005453-4057qib7 1995 10 original original JJ cord-005453-4057qib7 1995 11 disease disease NN cord-005453-4057qib7 1995 12 , , , cord-005453-4057qib7 1995 13 while while IN cord-005453-4057qib7 1995 14 six six CD cord-005453-4057qib7 1995 15 patients patient NNS cord-005453-4057qib7 1995 16 died die VBD cord-005453-4057qib7 1995 17 due due JJ cord-005453-4057qib7 1995 18 to to IN cord-005453-4057qib7 1995 19 transplant transplant NN cord-005453-4057qib7 1995 20 - - HYPH cord-005453-4057qib7 1995 21 related relate VBN cord-005453-4057qib7 1995 22 causes cause NNS cord-005453-4057qib7 1995 23 ( ( -LRB- cord-005453-4057qib7 1995 24 transplant transplant NN cord-005453-4057qib7 1995 25 - - HYPH cord-005453-4057qib7 1995 26 related relate VBN cord-005453-4057qib7 1995 27 mortality mortality NN cord-005453-4057qib7 1995 28 6.5 6.5 CD cord-005453-4057qib7 1995 29 % % NN cord-005453-4057qib7 1995 30 ) ) -RRB- cord-005453-4057qib7 1995 31 . . . cord-005453-4057qib7 1996 1 Immune immune JJ cord-005453-4057qib7 1996 2 reconstitution reconstitution NN cord-005453-4057qib7 1996 3 in in IN cord-005453-4057qib7 1996 4 alive alive JJ cord-005453-4057qib7 1996 5 patients patient NNS cord-005453-4057qib7 1996 6 was be VBD cord-005453-4057qib7 1996 7 achieved achieve VBN cord-005453-4057qib7 1996 8 at at IN cord-005453-4057qib7 1996 9 a a DT cord-005453-4057qib7 1996 10 median median NN cord-005453-4057qib7 1996 11 of of IN cord-005453-4057qib7 1996 12 eight eight CD cord-005453-4057qib7 1996 13 months month NNS cord-005453-4057qib7 1996 14 . . . cord-005453-4057qib7 1997 1 This this DT cord-005453-4057qib7 1997 2 time time NN cord-005453-4057qib7 1997 3 was be VBD cord-005453-4057qib7 1997 4 significantly significantly RB cord-005453-4057qib7 1997 5 longer long JJR cord-005453-4057qib7 1997 6 ( ( -LRB- cord-005453-4057qib7 1997 7 P0.034 P0.034 NNP cord-005453-4057qib7 1997 8 ) ) -RRB- cord-005453-4057qib7 1997 9 in in IN cord-005453-4057qib7 1997 10 FTT FTT NNP cord-005453-4057qib7 1997 11 group group NN cord-005453-4057qib7 1997 12 . . . cord-005453-4057qib7 1998 1 Conclusions conclusion NNS cord-005453-4057qib7 1998 2 : : : cord-005453-4057qib7 1999 1 This this DT cord-005453-4057qib7 1999 2 study study NN cord-005453-4057qib7 1999 3 demonstrates demonstrate VBZ cord-005453-4057qib7 1999 4 that that IN cord-005453-4057qib7 1999 5 Treosulfan Treosulfan NNP cord-005453-4057qib7 1999 6 is be VBZ cord-005453-4057qib7 1999 7 a a DT cord-005453-4057qib7 1999 8 safe safe JJ cord-005453-4057qib7 1999 9 and and CC cord-005453-4057qib7 1999 10 effective effective JJ cord-005453-4057qib7 1999 11 conditioning conditioning NN cord-005453-4057qib7 1999 12 drug drug NN cord-005453-4057qib7 1999 13 that that WDT cord-005453-4057qib7 1999 14 can can MD cord-005453-4057qib7 1999 15 achieve achieve VB cord-005453-4057qib7 1999 16 engraftment engraftment NN cord-005453-4057qib7 1999 17 , , , cord-005453-4057qib7 1999 18 with with IN cord-005453-4057qib7 1999 19 low low JJ cord-005453-4057qib7 1999 20 rates rate NNS cord-005453-4057qib7 1999 21 of of IN cord-005453-4057qib7 1999 22 graft graft NN cord-005453-4057qib7 1999 23 failure failure NN cord-005453-4057qib7 1999 24 , , , cord-005453-4057qib7 1999 25 transplantrelated transplantrelate VBN cord-005453-4057qib7 1999 26 mortality mortality NN cord-005453-4057qib7 1999 27 and and CC cord-005453-4057qib7 1999 28 morbidity morbidity NN cord-005453-4057qib7 1999 29 , , , cord-005453-4057qib7 1999 30 even even RB cord-005453-4057qib7 1999 31 if if IN cord-005453-4057qib7 1999 32 it -PRON- PRP cord-005453-4057qib7 1999 33 is be VBZ cord-005453-4057qib7 1999 34 used use VBN cord-005453-4057qib7 1999 35 twice twice RB cord-005453-4057qib7 1999 36 in in IN cord-005453-4057qib7 1999 37 the the DT cord-005453-4057qib7 1999 38 same same JJ cord-005453-4057qib7 1999 39 patient patient NN cord-005453-4057qib7 1999 40 . . . cord-005453-4057qib7 2000 1 Disclosure disclosure NN cord-005453-4057qib7 2000 2 : : : cord-005453-4057qib7 2001 1 Nothing nothing NN cord-005453-4057qib7 2001 2 to to TO cord-005453-4057qib7 2001 3 declare declare VB cord-005453-4057qib7 2001 4 Background background NN cord-005453-4057qib7 2001 5 : : : cord-005453-4057qib7 2001 6 High high JJ cord-005453-4057qib7 2001 7 - - HYPH cord-005453-4057qib7 2001 8 dose dose NN cord-005453-4057qib7 2001 9 chemotherapy chemotherapy NN cord-005453-4057qib7 2001 10 ( ( -LRB- cord-005453-4057qib7 2001 11 HDC HDC NNP cord-005453-4057qib7 2001 12 ) ) -RRB- cord-005453-4057qib7 2001 13 followed follow VBN cord-005453-4057qib7 2001 14 by by IN cord-005453-4057qib7 2001 15 autologous autologous JJ cord-005453-4057qib7 2001 16 stem stem NN cord-005453-4057qib7 2001 17 cell cell NN cord-005453-4057qib7 2001 18 transplantation transplantation NN cord-005453-4057qib7 2001 19 ( ( -LRB- cord-005453-4057qib7 2001 20 ASCT ASCT NNP cord-005453-4057qib7 2001 21 ) ) -RRB- cord-005453-4057qib7 2001 22 is be VBZ cord-005453-4057qib7 2001 23 the the DT cord-005453-4057qib7 2001 24 treatment treatment NN cord-005453-4057qib7 2001 25 of of IN cord-005453-4057qib7 2001 26 choice choice NN cord-005453-4057qib7 2001 27 for for IN cord-005453-4057qib7 2001 28 the the DT cord-005453-4057qib7 2001 29 patients patient NNS cord-005453-4057qib7 2001 30 with with IN cord-005453-4057qib7 2001 31 relapsed relapsed JJ cord-005453-4057qib7 2001 32 or or CC cord-005453-4057qib7 2001 33 high high JJ cord-005453-4057qib7 2001 34 risk risk NN cord-005453-4057qib7 2001 35 NHL NHL NNP cord-005453-4057qib7 2001 36 . . . cord-005453-4057qib7 2002 1 Although although IN cord-005453-4057qib7 2002 2 the the DT cord-005453-4057qib7 2002 3 high high JJ cord-005453-4057qib7 2002 4 - - HYPH cord-005453-4057qib7 2002 5 dose dose NN cord-005453-4057qib7 2002 6 conditioning conditioning NN cord-005453-4057qib7 2002 7 regimens regimen NNS cord-005453-4057qib7 2002 8 commonly commonly RB cord-005453-4057qib7 2002 9 used use VBN cord-005453-4057qib7 2002 10 in in IN cord-005453-4057qib7 2002 11 patients patient NNS cord-005453-4057qib7 2002 12 with with IN cord-005453-4057qib7 2002 13 non non JJ cord-005453-4057qib7 2002 14 - - JJ cord-005453-4057qib7 2002 15 Hodgkin hodgkin JJ cord-005453-4057qib7 2002 16 lymphoma lymphoma NN cord-005453-4057qib7 2002 17 ( ( -LRB- cord-005453-4057qib7 2002 18 NHL NHL NNP cord-005453-4057qib7 2002 19 ) ) -RRB- cord-005453-4057qib7 2002 20 are be VBP cord-005453-4057qib7 2002 21 BEAM beam NN cord-005453-4057qib7 2002 22 ( ( -LRB- cord-005453-4057qib7 2002 23 BCNU BCNU NNP cord-005453-4057qib7 2002 24 , , , cord-005453-4057qib7 2002 25 etoposide etoposide RB cord-005453-4057qib7 2002 26 , , , cord-005453-4057qib7 2002 27 cytarabine cytarabine NNP cord-005453-4057qib7 2002 28 , , , cord-005453-4057qib7 2002 29 and and CC cord-005453-4057qib7 2002 30 melphalan melphalan NNP cord-005453-4057qib7 2002 31 ) ) -RRB- cord-005453-4057qib7 2002 32 , , , cord-005453-4057qib7 2002 33 BEAC BEAC NNP cord-005453-4057qib7 2002 34 ( ( -LRB- cord-005453-4057qib7 2002 35 BCNU BCNU NNP cord-005453-4057qib7 2002 36 , , , cord-005453-4057qib7 2002 37 etoposide etoposide RB cord-005453-4057qib7 2002 38 , , , cord-005453-4057qib7 2002 39 cytarabine cytarabine NN cord-005453-4057qib7 2002 40 , , , cord-005453-4057qib7 2002 41 and and CC cord-005453-4057qib7 2002 42 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 2002 43 ) ) -RRB- cord-005453-4057qib7 2002 44 , , , cord-005453-4057qib7 2002 45 survival survival NN cord-005453-4057qib7 2002 46 of of IN cord-005453-4057qib7 2002 47 patients patient NNS cord-005453-4057qib7 2002 48 with with IN cord-005453-4057qib7 2002 49 NHL NHL NNP cord-005453-4057qib7 2002 50 received receive VBN cord-005453-4057qib7 2002 51 above above IN cord-005453-4057qib7 2002 52 high high JJ cord-005453-4057qib7 2002 53 - - HYPH cord-005453-4057qib7 2002 54 dose dose NN cord-005453-4057qib7 2002 55 chemotherapy chemotherapy NN cord-005453-4057qib7 2002 56 followed follow VBN cord-005453-4057qib7 2002 57 by by IN cord-005453-4057qib7 2002 58 ASCT ASCT NNP cord-005453-4057qib7 2002 59 was be VBD cord-005453-4057qib7 2002 60 still still RB cord-005453-4057qib7 2002 61 unsatisfactory unsatisfactory JJ cord-005453-4057qib7 2002 62 . . . cord-005453-4057qib7 2003 1 Methods method NNS cord-005453-4057qib7 2003 2 : : : cord-005453-4057qib7 2003 3 We -PRON- PRP cord-005453-4057qib7 2003 4 prospectively prospectively RB cord-005453-4057qib7 2003 5 evaluated evaluate VBD cord-005453-4057qib7 2003 6 the the DT cord-005453-4057qib7 2003 7 efficacy efficacy NN cord-005453-4057qib7 2003 8 and and CC cord-005453-4057qib7 2003 9 toxicity toxicity NN cord-005453-4057qib7 2003 10 of of IN cord-005453-4057qib7 2003 11 busulfan busulfan NN cord-005453-4057qib7 2003 12 , , , cord-005453-4057qib7 2003 13 etoposide etoposide RB cord-005453-4057qib7 2003 14 , , , cord-005453-4057qib7 2003 15 cytarabine cytarabine NNP cord-005453-4057qib7 2003 16 and and CC cord-005453-4057qib7 2003 17 melphalan melphalan NNP cord-005453-4057qib7 2003 18 ( ( -LRB- cord-005453-4057qib7 2003 19 BuEAM bueam RB cord-005453-4057qib7 2003 20 ) ) -RRB- cord-005453-4057qib7 2003 21 including include VBG cord-005453-4057qib7 2003 22 iv iv NNP cord-005453-4057qib7 2003 23 busulfan busulfan NNP cord-005453-4057qib7 2003 24 instead instead RB cord-005453-4057qib7 2003 25 of of IN cord-005453-4057qib7 2003 26 BCNU BCNU NNP cord-005453-4057qib7 2003 27 of of IN cord-005453-4057qib7 2003 28 standard standard JJ cord-005453-4057qib7 2003 29 BEAM BEAM NNP cord-005453-4057qib7 2003 30 as as IN cord-005453-4057qib7 2003 31 a a DT cord-005453-4057qib7 2003 32 conditioning conditioning NN cord-005453-4057qib7 2003 33 for for IN cord-005453-4057qib7 2003 34 ASCT ASCT NNP cord-005453-4057qib7 2003 35 in in IN cord-005453-4057qib7 2003 36 patients patient NNS cord-005453-4057qib7 2003 37 with with IN cord-005453-4057qib7 2003 38 NHL NHL NNP cord-005453-4057qib7 2003 39 . . . cord-005453-4057qib7 2004 1 The the DT cord-005453-4057qib7 2004 2 high high JJ cord-005453-4057qib7 2004 3 - - HYPH cord-005453-4057qib7 2004 4 dose dose NN cord-005453-4057qib7 2004 5 chemotherapy chemotherapy NN cord-005453-4057qib7 2004 6 consisted consist VBN cord-005453-4057qib7 2004 7 of of IN cord-005453-4057qib7 2004 8 Bu Bu NNP cord-005453-4057qib7 2004 9 ( ( -LRB- cord-005453-4057qib7 2004 10 3.2 3.2 CD cord-005453-4057qib7 2004 11 mg mg NNP cord-005453-4057qib7 2004 12 / / SYM cord-005453-4057qib7 2004 13 kg kg NNP cord-005453-4057qib7 2004 14 i.v i.v NNP cord-005453-4057qib7 2004 15 . . NNP cord-005453-4057qib7 2004 16 q.d q.d NNP cord-005453-4057qib7 2004 17 . . NNP cord-005453-4057qib7 2004 18 from from IN cord-005453-4057qib7 2004 19 day day NN cord-005453-4057qib7 2004 20 -6 -6 NNP cord-005453-4057qib7 2004 21 to to IN cord-005453-4057qib7 2004 22 day day NN cord-005453-4057qib7 2004 23 -5 -5 NNP cord-005453-4057qib7 2004 24 ) ) -RRB- cord-005453-4057qib7 2004 25 , , , cord-005453-4057qib7 2004 26 E E NNP cord-005453-4057qib7 2004 27 ( ( -LRB- cord-005453-4057qib7 2004 28 200 200 CD cord-005453-4057qib7 2004 29 mg mg NNP cord-005453-4057qib7 2004 30 / / SYM cord-005453-4057qib7 2004 31 m m NNP cord-005453-4057qib7 2004 32 2 2 CD cord-005453-4057qib7 2004 33 i.v i.v NNP cord-005453-4057qib7 2004 34 . . NNP cord-005453-4057qib7 2004 35 b.i.d b.i.d NNP cord-005453-4057qib7 2004 36 . . NNP cord-005453-4057qib7 2004 37 on on IN cord-005453-4057qib7 2004 38 day day NN cord-005453-4057qib7 2004 39 -4 -4 NNP cord-005453-4057qib7 2004 40 and and CC cord-005453-4057qib7 2004 41 day day NN cord-005453-4057qib7 2004 42 -3 -3 NNP cord-005453-4057qib7 2004 43 ) ) -RRB- cord-005453-4057qib7 2005 1 A a DT cord-005453-4057qib7 2005 2 ( ( -LRB- cord-005453-4057qib7 2005 3 1 1 CD cord-005453-4057qib7 2005 4 g g NN cord-005453-4057qib7 2005 5 / / SYM cord-005453-4057qib7 2005 6 m m NNP cord-005453-4057qib7 2005 7 2 2 CD cord-005453-4057qib7 2005 8 i.v i.v NNP cord-005453-4057qib7 2005 9 . . NNP cord-005453-4057qib7 2005 10 q.d q.d NNP cord-005453-4057qib7 2005 11 . . . cord-005453-4057qib7 2006 1 on on IN cord-005453-4057qib7 2006 2 day day NN cord-005453-4057qib7 2006 3 -4 -4 NNP cord-005453-4057qib7 2006 4 and and CC cord-005453-4057qib7 2006 5 day day NN cord-005453-4057qib7 2006 6 -3 -3 NNP cord-005453-4057qib7 2006 7 ) ) -RRB- cord-005453-4057qib7 2007 1 and and CC cord-005453-4057qib7 2007 2 M M NNP cord-005453-4057qib7 2007 3 ( ( -LRB- cord-005453-4057qib7 2007 4 140 140 CD cord-005453-4057qib7 2007 5 mg mg NNP cord-005453-4057qib7 2007 6 / / SYM cord-005453-4057qib7 2007 7 m m NNP cord-005453-4057qib7 2007 8 2 2 CD cord-005453-4057qib7 2007 9 i.v i.v NNP cord-005453-4057qib7 2007 10 . . NNP cord-005453-4057qib7 2007 11 q.d q.d NNP cord-005453-4057qib7 2007 12 . . NNP cord-005453-4057qib7 2007 13 on on IN cord-005453-4057qib7 2007 14 day day NN cord-005453-4057qib7 2007 15 -2 -2 CD cord-005453-4057qib7 2007 16 ) ) -RRB- cord-005453-4057qib7 2007 17 at at IN cord-005453-4057qib7 2007 18 7 7 CD cord-005453-4057qib7 2007 19 centers center NNS cord-005453-4057qib7 2007 20 in in IN cord-005453-4057qib7 2007 21 Korea Korea NNP cord-005453-4057qib7 2007 22 . . . cord-005453-4057qib7 2008 1 Results result NNS cord-005453-4057qib7 2008 2 : : : cord-005453-4057qib7 2009 1 Two two CD cord-005453-4057qib7 2009 2 hundred hundred CD cord-005453-4057qib7 2009 3 five five CD cord-005453-4057qib7 2009 4 patients patient NNS cord-005453-4057qib7 2009 5 were be VBD cord-005453-4057qib7 2009 6 enrolled enrol VBN cord-005453-4057qib7 2009 7 onto onto IN cord-005453-4057qib7 2009 8 the the DT cord-005453-4057qib7 2009 9 study study NN cord-005453-4057qib7 2009 10 . . . cord-005453-4057qib7 2010 1 Main main JJ cord-005453-4057qib7 2010 2 subgroup subgroup NN cord-005453-4057qib7 2010 3 was be VBD cord-005453-4057qib7 2010 4 diffuse diffuse JJ cord-005453-4057qib7 2010 5 large large JJ cord-005453-4057qib7 2010 6 B b NN cord-005453-4057qib7 2010 7 cell cell NN cord-005453-4057qib7 2010 8 lymphoma lymphoma NN cord-005453-4057qib7 2010 9 ( ( -LRB- cord-005453-4057qib7 2010 10 n=104 n=104 NNP cord-005453-4057qib7 2010 11 , , , cord-005453-4057qib7 2010 12 50.7 50.7 CD cord-005453-4057qib7 2010 13 % % NN cord-005453-4057qib7 2010 14 ) ) -RRB- cord-005453-4057qib7 2010 15 , , , cord-005453-4057qib7 2010 16 T t NN cord-005453-4057qib7 2010 17 cell cell NN cord-005453-4057qib7 2010 18 lymphomas lymphoma NNS cord-005453-4057qib7 2010 19 ( ( -LRB- cord-005453-4057qib7 2010 20 n=59 n=59 FW cord-005453-4057qib7 2010 21 , , , cord-005453-4057qib7 2010 22 29.8 29.8 CD cord-005453-4057qib7 2010 23 % % NN cord-005453-4057qib7 2010 24 ) ) -RRB- cord-005453-4057qib7 2010 25 , , , cord-005453-4057qib7 2010 26 and and CC cord-005453-4057qib7 2010 27 NK NK NNP cord-005453-4057qib7 2010 28 / / SYM cord-005453-4057qib7 2010 29 T T NNP cord-005453-4057qib7 2010 30 cell cell NN cord-005453-4057qib7 2010 31 lymphoma lymphoma NN cord-005453-4057qib7 2010 32 ( ( -LRB- cord-005453-4057qib7 2010 33 n=22 n=22 NNP cord-005453-4057qib7 2010 34 , , , cord-005453-4057qib7 2010 35 10.7 10.7 CD cord-005453-4057qib7 2010 36 % % NN cord-005453-4057qib7 2010 37 ) ) -RRB- cord-005453-4057qib7 2010 38 . . . cord-005453-4057qib7 2011 1 Upfront Upfront NNP cord-005453-4057qib7 2011 2 ASCT ASCT NNP cord-005453-4057qib7 2011 3 was be VBD cord-005453-4057qib7 2011 4 performed perform VBN cord-005453-4057qib7 2011 5 in in IN cord-005453-4057qib7 2011 6 160 160 CD cord-005453-4057qib7 2011 7 patients patient NNS cord-005453-4057qib7 2011 8 ( ( -LRB- cord-005453-4057qib7 2011 9 78.0 78.0 CD cord-005453-4057qib7 2011 10 % % NN cord-005453-4057qib7 2011 11 ) ) -RRB- cord-005453-4057qib7 2011 12 , , , cord-005453-4057qib7 2011 13 and and CC cord-005453-4057qib7 2011 14 salvage salvage VB cord-005453-4057qib7 2011 15 ASCT ASCT NNP cord-005453-4057qib7 2011 16 in in IN cord-005453-4057qib7 2011 17 45 45 CD cord-005453-4057qib7 2011 18 patients patient NNS cord-005453-4057qib7 2011 19 ( ( -LRB- cord-005453-4057qib7 2011 20 22.0 22.0 CD cord-005453-4057qib7 2011 21 % % NN cord-005453-4057qib7 2011 22 ) ) -RRB- cord-005453-4057qib7 2011 23 . . . cord-005453-4057qib7 2012 1 The the DT cord-005453-4057qib7 2012 2 disease disease NN cord-005453-4057qib7 2012 3 status status NN cord-005453-4057qib7 2012 4 of of IN cord-005453-4057qib7 2012 5 the the DT cord-005453-4057qib7 2012 6 patients patient NNS cord-005453-4057qib7 2012 7 before before IN cord-005453-4057qib7 2012 8 HDT HDT NNP cord-005453-4057qib7 2012 9 / / SYM cord-005453-4057qib7 2012 10 ASCT ASCT NNP cord-005453-4057qib7 2012 11 consisted consist VBD cord-005453-4057qib7 2012 12 of of IN cord-005453-4057qib7 2012 13 133 133 CD cord-005453-4057qib7 2012 14 patients patient NNS cord-005453-4057qib7 2012 15 ( ( -LRB- cord-005453-4057qib7 2012 16 64.8 64.8 CD cord-005453-4057qib7 2012 17 % % NN cord-005453-4057qib7 2012 18 ) ) -RRB- cord-005453-4057qib7 2012 19 with with IN cord-005453-4057qib7 2012 20 complete complete JJ cord-005453-4057qib7 2012 21 response response NN cord-005453-4057qib7 2012 22 and and CC cord-005453-4057qib7 2012 23 72 72 CD cord-005453-4057qib7 2012 24 patients patient NNS cord-005453-4057qib7 2012 25 ( ( -LRB- cord-005453-4057qib7 2012 26 35.2 35.2 CD cord-005453-4057qib7 2012 27 % % NN cord-005453-4057qib7 2012 28 ) ) -RRB- cord-005453-4057qib7 2012 29 with with IN cord-005453-4057qib7 2012 30 partial partial JJ cord-005453-4057qib7 2012 31 response response NN cord-005453-4057qib7 2012 32 . . . cord-005453-4057qib7 2013 1 Treatment treatment NN cord-005453-4057qib7 2013 2 related related JJ cord-005453-4057qib7 2013 3 toxicities toxicity NNS cord-005453-4057qib7 2013 4 included include VBD cord-005453-4057qib7 2013 5 nausea nausea NN cord-005453-4057qib7 2013 6 in in IN cord-005453-4057qib7 2013 7 149 149 CD cord-005453-4057qib7 2013 8 patients patient NNS cord-005453-4057qib7 2013 9 ( ( -LRB- cord-005453-4057qib7 2013 10 72.7 72.7 CD cord-005453-4057qib7 2013 11 % % NN cord-005453-4057qib7 2013 12 ) ) -RRB- cord-005453-4057qib7 2013 13 , , , cord-005453-4057qib7 2013 14 diarrhea diarrhea NN cord-005453-4057qib7 2013 15 in in IN cord-005453-4057qib7 2013 16 127 127 CD cord-005453-4057qib7 2013 17 patients patient NNS cord-005453-4057qib7 2013 18 ( ( -LRB- cord-005453-4057qib7 2013 19 62.0 62.0 CD cord-005453-4057qib7 2013 20 % % NN cord-005453-4057qib7 2013 21 ) ) -RRB- cord-005453-4057qib7 2013 22 , , , cord-005453-4057qib7 2013 23 anorexia anorexia VBN cord-005453-4057qib7 2013 24 in in IN cord-005453-4057qib7 2013 25 107 107 CD cord-005453-4057qib7 2013 26 patients patient NNS cord-005453-4057qib7 2013 27 ( ( -LRB- cord-005453-4057qib7 2013 28 52.2 52.2 CD cord-005453-4057qib7 2013 29 % % NN cord-005453-4057qib7 2013 30 ) ) -RRB- cord-005453-4057qib7 2013 31 and and CC cord-005453-4057qib7 2013 32 stomatitis stomatitis NN cord-005453-4057qib7 2013 33 in in IN cord-005453-4057qib7 2013 34 97 97 CD cord-005453-4057qib7 2013 35 patients patient NNS cord-005453-4057qib7 2013 36 ( ( -LRB- cord-005453-4057qib7 2013 37 47.3 47.3 CD cord-005453-4057qib7 2013 38 % % NN cord-005453-4057qib7 2013 39 ) ) -RRB- cord-005453-4057qib7 2013 40 , , , cord-005453-4057qib7 2013 41 which which WDT cord-005453-4057qib7 2013 42 were be VBD cord-005453-4057qib7 2013 43 grade grade NN cord-005453-4057qib7 2013 44 I -PRON- PRP cord-005453-4057qib7 2013 45 or or CC cord-005453-4057qib7 2013 46 II II NNP cord-005453-4057qib7 2013 47 in in IN cord-005453-4057qib7 2013 48 the the DT cord-005453-4057qib7 2013 49 majority majority NN cord-005453-4057qib7 2013 50 of of IN cord-005453-4057qib7 2013 51 cases case NNS cord-005453-4057qib7 2013 52 . . . cord-005453-4057qib7 2014 1 The the DT cord-005453-4057qib7 2014 2 common common JJ cord-005453-4057qib7 2014 3 grade grade NN cord-005453-4057qib7 2014 4 III iii CD cord-005453-4057qib7 2014 5 toxicities toxicity NNS cord-005453-4057qib7 2014 6 were be VBD cord-005453-4057qib7 2014 7 stomatitis stomatitis JJ cord-005453-4057qib7 2014 8 ( ( -LRB- cord-005453-4057qib7 2014 9 6.9 6.9 CD cord-005453-4057qib7 2014 10 % % NN cord-005453-4057qib7 2014 11 ) ) -RRB- cord-005453-4057qib7 2014 12 , , , cord-005453-4057qib7 2014 13 diarrhea diarrhea NN cord-005453-4057qib7 2014 14 ( ( -LRB- cord-005453-4057qib7 2014 15 5.9 5.9 CD cord-005453-4057qib7 2014 16 % % NN cord-005453-4057qib7 2014 17 ) ) -RRB- cord-005453-4057qib7 2014 18 , , , cord-005453-4057qib7 2014 19 and and CC cord-005453-4057qib7 2014 20 anorexia anorexia NN cord-005453-4057qib7 2014 21 ( ( -LRB- cord-005453-4057qib7 2014 22 5.4 5.4 CD cord-005453-4057qib7 2014 23 % % NN cord-005453-4057qib7 2014 24 ) ) -RRB- cord-005453-4057qib7 2014 25 . . . cord-005453-4057qib7 2015 1 There there EX cord-005453-4057qib7 2015 2 were be VBD cord-005453-4057qib7 2015 3 no no DT cord-005453-4057qib7 2015 4 VOD vod NN cord-005453-4057qib7 2015 5 , , , cord-005453-4057qib7 2015 6 and and CC cord-005453-4057qib7 2015 7 transplant transplant NN cord-005453-4057qib7 2015 8 - - HYPH cord-005453-4057qib7 2015 9 related relate VBN cord-005453-4057qib7 2015 10 mortality mortality NN cord-005453-4057qib7 2015 11 occurred occur VBD cord-005453-4057qib7 2015 12 in in IN cord-005453-4057qib7 2015 13 4 4 CD cord-005453-4057qib7 2015 14 patients patient NNS cord-005453-4057qib7 2015 15 ( ( -LRB- cord-005453-4057qib7 2015 16 1.95 1.95 CD cord-005453-4057qib7 2015 17 % % NN cord-005453-4057qib7 2015 18 ) ) -RRB- cord-005453-4057qib7 2015 19 , , , cord-005453-4057qib7 2015 20 due due IN cord-005453-4057qib7 2015 21 to to IN cord-005453-4057qib7 2015 22 infection infection NN cord-005453-4057qib7 2015 23 . . . cord-005453-4057qib7 2016 1 One one CD cord-005453-4057qib7 2016 2 hundred hundred CD cord-005453-4057qib7 2016 3 fifty fifty CD cord-005453-4057qib7 2016 4 three three CD cord-005453-4057qib7 2016 5 patients patient NNS cord-005453-4057qib7 2016 6 ( ( -LRB- cord-005453-4057qib7 2016 7 74.6 74.6 CD cord-005453-4057qib7 2016 8 % % NN cord-005453-4057qib7 2016 9 ) ) -RRB- cord-005453-4057qib7 2016 10 achieved achieve VBD cord-005453-4057qib7 2016 11 a a DT cord-005453-4057qib7 2016 12 complete complete JJ cord-005453-4057qib7 2016 13 response response NN cord-005453-4057qib7 2016 14 and and CC cord-005453-4057qib7 2016 15 13 13 CD cord-005453-4057qib7 2016 16 patients patient NNS cord-005453-4057qib7 2016 17 ( ( -LRB- cord-005453-4057qib7 2016 18 6.3 6.3 CD cord-005453-4057qib7 2016 19 % % NN cord-005453-4057qib7 2016 20 ) ) -RRB- cord-005453-4057qib7 2016 21 after after IN cord-005453-4057qib7 2016 22 ASCT ASCT NNP cord-005453-4057qib7 2016 23 , , , cord-005453-4057qib7 2016 24 while while IN cord-005453-4057qib7 2016 25 28 28 CD cord-005453-4057qib7 2016 26 patients patient NNS cord-005453-4057qib7 2016 27 ( ( -LRB- cord-005453-4057qib7 2016 28 13.7 13.7 CD cord-005453-4057qib7 2016 29 % % NN cord-005453-4057qib7 2016 30 ) ) -RRB- cord-005453-4057qib7 2016 31 showed show VBD cord-005453-4057qib7 2016 32 progressive progressive JJ cord-005453-4057qib7 2016 33 disease disease NN cord-005453-4057qib7 2016 34 . . . cord-005453-4057qib7 2017 1 At at IN cord-005453-4057qib7 2017 2 a a DT cord-005453-4057qib7 2017 3 median median JJ cord-005453-4057qib7 2017 4 follow follow NN cord-005453-4057qib7 2017 5 - - HYPH cord-005453-4057qib7 2017 6 up up NN cord-005453-4057qib7 2017 7 duration duration NN cord-005453-4057qib7 2017 8 of of IN cord-005453-4057qib7 2017 9 38.6 38.6 CD cord-005453-4057qib7 2017 10 months month NNS cord-005453-4057qib7 2017 11 , , , cord-005453-4057qib7 2017 12 the the DT cord-005453-4057qib7 2017 13 estimated estimate VBN cord-005453-4057qib7 2017 14 3-year 3-year CD cord-005453-4057qib7 2017 15 overall overall JJ cord-005453-4057qib7 2017 16 survival survival NN cord-005453-4057qib7 2017 17 and and CC cord-005453-4057qib7 2017 18 progression progression NN cord-005453-4057qib7 2017 19 free free JJ cord-005453-4057qib7 2017 20 survival survival NN cord-005453-4057qib7 2017 21 for for IN cord-005453-4057qib7 2017 22 all all DT cord-005453-4057qib7 2017 23 patients patient NNS cord-005453-4057qib7 2017 24 was be VBD cord-005453-4057qib7 2017 25 74.5 74.5 CD cord-005453-4057qib7 2017 26 % % NN cord-005453-4057qib7 2017 27 and and CC cord-005453-4057qib7 2017 28 56.6 56.6 CD cord-005453-4057qib7 2017 29 % % NN cord-005453-4057qib7 2017 30 , , , cord-005453-4057qib7 2017 31 respectively respectively RB cord-005453-4057qib7 2017 32 . . . cord-005453-4057qib7 2018 1 Conclusions conclusion NNS cord-005453-4057qib7 2018 2 : : : cord-005453-4057qib7 2019 1 The the DT cord-005453-4057qib7 2019 2 conditioning conditioning NN cord-005453-4057qib7 2019 3 regimen regimen NN cord-005453-4057qib7 2019 4 of of IN cord-005453-4057qib7 2019 5 BuEAM BuEAM NNP cord-005453-4057qib7 2019 6 for for IN cord-005453-4057qib7 2019 7 ASCT ASCT NNP cord-005453-4057qib7 2019 8 was be VBD cord-005453-4057qib7 2019 9 well well RB cord-005453-4057qib7 2019 10 tolerated tolerate VBN cord-005453-4057qib7 2019 11 and and CC cord-005453-4057qib7 2019 12 seemed seem VBD cord-005453-4057qib7 2019 13 to to TO cord-005453-4057qib7 2019 14 be be VB cord-005453-4057qib7 2019 15 effective effective JJ cord-005453-4057qib7 2019 16 in in IN cord-005453-4057qib7 2019 17 patients patient NNS cord-005453-4057qib7 2019 18 with with IN cord-005453-4057qib7 2019 19 relapsed relapsed JJ cord-005453-4057qib7 2019 20 or or CC cord-005453-4057qib7 2019 21 high high JJ cord-005453-4057qib7 2019 22 risk risk NN cord-005453-4057qib7 2019 23 NHL NHL NNP cord-005453-4057qib7 2019 24 . . . cord-005453-4057qib7 2020 1 Disclosure disclosure NN cord-005453-4057qib7 2020 2 : : : cord-005453-4057qib7 2021 1 None none NN cord-005453-4057qib7 2021 2 of of IN cord-005453-4057qib7 2021 3 declare declare VB cord-005453-4057qib7 2021 4 Background background NN cord-005453-4057qib7 2021 5 : : : cord-005453-4057qib7 2021 6 Allogeneic allogeneic NN cord-005453-4057qib7 2021 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 2021 8 cell cell NN cord-005453-4057qib7 2021 9 transplantation transplantation NN cord-005453-4057qib7 2021 10 ( ( -LRB- cord-005453-4057qib7 2021 11 HCT HCT NNP cord-005453-4057qib7 2021 12 ) ) -RRB- cord-005453-4057qib7 2021 13 is be VBZ cord-005453-4057qib7 2021 14 potentially potentially RB cord-005453-4057qib7 2021 15 curative curative JJ cord-005453-4057qib7 2021 16 for for IN cord-005453-4057qib7 2021 17 high high JJ cord-005453-4057qib7 2021 18 risk risk NN cord-005453-4057qib7 2021 19 acute acute JJ cord-005453-4057qib7 2021 20 myeloid myeloid NN cord-005453-4057qib7 2021 21 leukemia leukemia NN cord-005453-4057qib7 2021 22 ( ( -LRB- cord-005453-4057qib7 2021 23 AML AML NNP cord-005453-4057qib7 2021 24 ) ) -RRB- cord-005453-4057qib7 2021 25 and and CC cord-005453-4057qib7 2021 26 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 2021 27 syndrome syndrome NN cord-005453-4057qib7 2021 28 ( ( -LRB- cord-005453-4057qib7 2021 29 MDS MDS NNP cord-005453-4057qib7 2021 30 ) ) -RRB- cord-005453-4057qib7 2021 31 , , , cord-005453-4057qib7 2021 32 however however RB cord-005453-4057qib7 2021 33 both both DT cord-005453-4057qib7 2021 34 GvHD gvhd NN cord-005453-4057qib7 2021 35 and and CC cord-005453-4057qib7 2021 36 disease disease NN cord-005453-4057qib7 2022 1 relapse relapse NN cord-005453-4057qib7 2022 2 remain remain VBP cord-005453-4057qib7 2022 3 major major JJ cord-005453-4057qib7 2022 4 challenges challenge NNS cord-005453-4057qib7 2022 5 . . . cord-005453-4057qib7 2023 1 We -PRON- PRP cord-005453-4057qib7 2023 2 recently recently RB cord-005453-4057qib7 2023 3 introduced introduce VBD cord-005453-4057qib7 2023 4 a a DT cord-005453-4057qib7 2023 5 combination combination NN cord-005453-4057qib7 2023 6 of of IN cord-005453-4057qib7 2023 7 posttransplant posttransplant NN cord-005453-4057qib7 2023 8 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 2023 9 ( ( -LRB- cord-005453-4057qib7 2023 10 PTCy PTCy NNP cord-005453-4057qib7 2023 11 ) ) -RRB- cord-005453-4057qib7 2023 12 and and CC cord-005453-4057qib7 2023 13 ATG ATG NNP cord-005453-4057qib7 2023 14 ( ( -LRB- cord-005453-4057qib7 2023 15 4.5 4.5 CD cord-005453-4057qib7 2023 16 mg mg NNP cord-005453-4057qib7 2023 17 / / SYM cord-005453-4057qib7 2023 18 kg kg NNP cord-005453-4057qib7 2023 19 ) ) -RRB- cord-005453-4057qib7 2023 20 as as IN cord-005453-4057qib7 2023 21 graft graft NN cord-005453-4057qib7 2023 22 - - HYPH cord-005453-4057qib7 2023 23 versus versus IN cord-005453-4057qib7 2023 24 - - HYPH cord-005453-4057qib7 2023 25 host host NN cord-005453-4057qib7 2023 26 disease disease NN cord-005453-4057qib7 2023 27 ( ( -LRB- cord-005453-4057qib7 2023 28 GvHD GvHD NNP cord-005453-4057qib7 2023 29 ) ) -RRB- cord-005453-4057qib7 2023 30 prophylaxis prophylaxis NN cord-005453-4057qib7 2023 31 . . . cord-005453-4057qib7 2024 1 The the DT cord-005453-4057qib7 2024 2 purpose purpose NN cord-005453-4057qib7 2024 3 of of IN cord-005453-4057qib7 2024 4 our -PRON- PRP$ cord-005453-4057qib7 2024 5 study study NN cord-005453-4057qib7 2024 6 was be VBD cord-005453-4057qib7 2024 7 to to TO cord-005453-4057qib7 2024 8 compare compare VB cord-005453-4057qib7 2024 9 outcomes outcome NNS cord-005453-4057qib7 2024 10 between between IN cord-005453-4057qib7 2024 11 PTCy/ PTCy/ NNP cord-005453-4057qib7 2024 12 ATG ATG NNP cord-005453-4057qib7 2024 13 and and CC cord-005453-4057qib7 2024 14 other other JJ cord-005453-4057qib7 2024 15 GvHD GvHD NNP cord-005453-4057qib7 2024 16 prophylaxis prophylaxis NN cord-005453-4057qib7 2024 17 regimens regimen NNS cord-005453-4057qib7 2024 18 for for IN cord-005453-4057qib7 2024 19 high high JJ cord-005453-4057qib7 2024 20 risk risk NN cord-005453-4057qib7 2024 21 AML AML NNP cord-005453-4057qib7 2024 22 and and CC cord-005453-4057qib7 2024 23 MDS MDS NNP cord-005453-4057qib7 2024 24 . . . cord-005453-4057qib7 2025 1 Methods method NNS cord-005453-4057qib7 2025 2 : : : cord-005453-4057qib7 2026 1 We -PRON- PRP cord-005453-4057qib7 2026 2 retrospectively retrospectively RB cord-005453-4057qib7 2026 3 investigated investigate VBD cord-005453-4057qib7 2026 4 outcomes outcome NNS cord-005453-4057qib7 2026 5 of of IN cord-005453-4057qib7 2026 6 159 159 CD cord-005453-4057qib7 2026 7 patients patient NNS cord-005453-4057qib7 2026 8 that that WDT cord-005453-4057qib7 2026 9 underwent undergo VBD cord-005453-4057qib7 2026 10 allogeneic allogeneic NN cord-005453-4057qib7 2026 11 HCT hct NN cord-005453-4057qib7 2026 12 between between IN cord-005453-4057qib7 2026 13 January January NNP cord-005453-4057qib7 2026 14 2014 2014 CD cord-005453-4057qib7 2026 15 and and CC cord-005453-4057qib7 2026 16 July July NNP cord-005453-4057qib7 2026 17 2017 2017 CD cord-005453-4057qib7 2026 18 for for IN cord-005453-4057qib7 2026 19 high high JJ cord-005453-4057qib7 2026 20 risk risk NN cord-005453-4057qib7 2026 21 AML AML NNP cord-005453-4057qib7 2026 22 ( ( -LRB- cord-005453-4057qib7 2026 23 n=120 n=120 UH cord-005453-4057qib7 2026 24 , , , cord-005453-4057qib7 2026 25 75 75 CD cord-005453-4057qib7 2026 26 % % NN cord-005453-4057qib7 2026 27 ) ) -RRB- cord-005453-4057qib7 2026 28 and and CC cord-005453-4057qib7 2026 29 MDS MDS NNP cord-005453-4057qib7 2026 30 ( ( -LRB- cord-005453-4057qib7 2026 31 n=39 n=39 NNP cord-005453-4057qib7 2026 32 , , , cord-005453-4057qib7 2026 33 25 25 CD cord-005453-4057qib7 2026 34 % % NN cord-005453-4057qib7 2026 35 ) ) -RRB- cord-005453-4057qib7 2026 36 . . . cord-005453-4057qib7 2027 1 GvHD GvHD NNP cord-005453-4057qib7 2027 2 prophylaxis prophylaxis NN cord-005453-4057qib7 2027 3 regimens regimen NNS cord-005453-4057qib7 2027 4 were be VBD cord-005453-4057qib7 2027 5 compared compare VBN cord-005453-4057qib7 2027 6 for for IN cord-005453-4057qib7 2027 7 overall overall JJ cord-005453-4057qib7 2027 8 survival survival NN cord-005453-4057qib7 2027 9 ( ( -LRB- cord-005453-4057qib7 2027 10 OS OS NNP cord-005453-4057qib7 2027 11 ) ) -RRB- cord-005453-4057qib7 2027 12 , , , cord-005453-4057qib7 2027 13 cumulative cumulative JJ cord-005453-4057qib7 2027 14 incidence incidence NN cord-005453-4057qib7 2027 15 of of IN cord-005453-4057qib7 2027 16 relapse relapse NN cord-005453-4057qib7 2027 17 ( ( -LRB- cord-005453-4057qib7 2027 18 CIR CIR NNP cord-005453-4057qib7 2027 19 ) ) -RRB- cord-005453-4057qib7 2027 20 and and CC cord-005453-4057qib7 2027 21 non non JJ cord-005453-4057qib7 2027 22 - - JJ cord-005453-4057qib7 2027 23 relapse relapse JJ cord-005453-4057qib7 2027 24 mortality mortality NN cord-005453-4057qib7 2027 25 ( ( -LRB- cord-005453-4057qib7 2027 26 NRM NRM NNP cord-005453-4057qib7 2027 27 ) ) -RRB- cord-005453-4057qib7 2027 28 in in IN cord-005453-4057qib7 2027 29 univariate univariate JJ cord-005453-4057qib7 2027 30 and and CC cord-005453-4057qib7 2027 31 multivariable multivariable JJ cord-005453-4057qib7 2027 32 analysis analysis NN cord-005453-4057qib7 2027 33 . . . cord-005453-4057qib7 2028 1 High high JJ cord-005453-4057qib7 2028 2 risk risk NN cord-005453-4057qib7 2028 3 AML AML NNP cord-005453-4057qib7 2028 4 was be VBD cord-005453-4057qib7 2028 5 defined define VBN cord-005453-4057qib7 2028 6 as as IN cord-005453-4057qib7 2028 7 secondary secondary JJ cord-005453-4057qib7 2028 8 AML AML NNP cord-005453-4057qib7 2028 9 , , , cord-005453-4057qib7 2028 10 therapy therapy NN cord-005453-4057qib7 2028 11 related relate VBD cord-005453-4057qib7 2028 12 AML AML NNP cord-005453-4057qib7 2028 13 , , , cord-005453-4057qib7 2028 14 high high JJ cord-005453-4057qib7 2028 15 risk risk NN cord-005453-4057qib7 2028 16 cytogenetics cytogenetic NNS cord-005453-4057qib7 2028 17 ( ( -LRB- cord-005453-4057qib7 2028 18 ELN ELN NNP cord-005453-4057qib7 2028 19 criteria criterion NNS cord-005453-4057qib7 2028 20 ) ) -RRB- cord-005453-4057qib7 2029 1 in in IN cord-005453-4057qib7 2029 2 CR1 CR1 NNP cord-005453-4057qib7 2029 3 , , , cord-005453-4057qib7 2029 4 good/ good/ CD cord-005453-4057qib7 2029 5 intermediate intermediate JJ cord-005453-4057qib7 2029 6 cytogenetic cytogenetic JJ cord-005453-4057qib7 2029 7 risk risk NN cord-005453-4057qib7 2029 8 AML AML NNP cord-005453-4057qib7 2029 9 in in IN cord-005453-4057qib7 2029 10 CR2 CR2 NNP cord-005453-4057qib7 2029 11 and and CC cord-005453-4057qib7 2029 12 primary primary JJ cord-005453-4057qib7 2029 13 induction induction NN cord-005453-4057qib7 2029 14 failure failure NN cord-005453-4057qib7 2029 15 ; ; : cord-005453-4057qib7 2029 16 high high JJ cord-005453-4057qib7 2029 17 risk risk NN cord-005453-4057qib7 2029 18 MDS MDS NNP cord-005453-4057qib7 2029 19 was be VBD cord-005453-4057qib7 2029 20 defined define VBN cord-005453-4057qib7 2029 21 as as IN cord-005453-4057qib7 2029 22 high high JJ cord-005453-4057qib7 2029 23 / / , cord-005453-4057qib7 2029 24 very very RB cord-005453-4057qib7 2029 25 high high JJ cord-005453-4057qib7 2029 26 risk risk NN cord-005453-4057qib7 2029 27 WPSS WPSS NNP cord-005453-4057qib7 2029 28 score score NN cord-005453-4057qib7 2029 29 . . . cord-005453-4057qib7 2030 1 Results result NNS cord-005453-4057qib7 2030 2 : : : cord-005453-4057qib7 2031 1 Median median JJ cord-005453-4057qib7 2031 2 age age NN cord-005453-4057qib7 2031 3 of of IN cord-005453-4057qib7 2031 4 patients patient NNS cord-005453-4057qib7 2031 5 was be VBD cord-005453-4057qib7 2031 6 56 56 CD cord-005453-4057qib7 2031 7 years year NNS cord-005453-4057qib7 2032 1 ( ( -LRB- cord-005453-4057qib7 2032 2 range range NNP cord-005453-4057qib7 2032 3 22 22 CD cord-005453-4057qib7 2032 4 - - SYM cord-005453-4057qib7 2032 5 73 73 CD cord-005453-4057qib7 2032 6 years year NNS cord-005453-4057qib7 2032 7 ) ) -RRB- cord-005453-4057qib7 2032 8 . . . cord-005453-4057qib7 2033 1 Donors donor NNS cord-005453-4057qib7 2033 2 were be VBD cord-005453-4057qib7 2033 3 matched match VBN cord-005453-4057qib7 2033 4 related relate VBN cord-005453-4057qib7 2033 5 in in IN cord-005453-4057qib7 2033 6 52 52 CD cord-005453-4057qib7 2033 7 ( ( -LRB- cord-005453-4057qib7 2033 8 33 33 CD cord-005453-4057qib7 2033 9 % % NN cord-005453-4057qib7 2033 10 ) ) -RRB- cord-005453-4057qib7 2033 11 patients patient NNS cord-005453-4057qib7 2033 12 , , , cord-005453-4057qib7 2033 13 matched match VBN cord-005453-4057qib7 2033 14 unrelated unrelated JJ cord-005453-4057qib7 2033 15 in in IN cord-005453-4057qib7 2033 16 89 89 CD cord-005453-4057qib7 2033 17 ( ( -LRB- cord-005453-4057qib7 2033 18 56 56 CD cord-005453-4057qib7 2033 19 % % NN cord-005453-4057qib7 2033 20 ) ) -RRB- cord-005453-4057qib7 2033 21 patients patient NNS cord-005453-4057qib7 2033 22 and and CC cord-005453-4057qib7 2033 23 haploidentical haploidentical JJ cord-005453-4057qib7 2033 24 in in IN cord-005453-4057qib7 2033 25 18 18 CD cord-005453-4057qib7 2033 26 ( ( -LRB- cord-005453-4057qib7 2033 27 11 11 CD cord-005453-4057qib7 2033 28 % % NN cord-005453-4057qib7 2033 29 ) ) -RRB- cord-005453-4057qib7 2033 30 patients patient NNS cord-005453-4057qib7 2033 31 . . . cord-005453-4057qib7 2034 1 Graft graft NN cord-005453-4057qib7 2034 2 source source NN cord-005453-4057qib7 2034 3 was be VBD cord-005453-4057qib7 2034 4 peripheral peripheral JJ cord-005453-4057qib7 2034 5 blood blood NN cord-005453-4057qib7 2034 6 stem stem NN cord-005453-4057qib7 2034 7 cells cell NNS cord-005453-4057qib7 2034 8 in in IN cord-005453-4057qib7 2034 9 158 158 CD cord-005453-4057qib7 2034 10 patients patient NNS cord-005453-4057qib7 2034 11 ( ( -LRB- cord-005453-4057qib7 2034 12 99 99 CD cord-005453-4057qib7 2034 13 % % NN cord-005453-4057qib7 2034 14 ) ) -RRB- cord-005453-4057qib7 2034 15 . . . cord-005453-4057qib7 2035 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 2035 2 conditioning conditioning NN cord-005453-4057qib7 2035 3 was be VBD cord-005453-4057qib7 2035 4 used use VBN cord-005453-4057qib7 2035 5 in in IN cord-005453-4057qib7 2035 6 54 54 CD cord-005453-4057qib7 2035 7 patients patient NNS cord-005453-4057qib7 2035 8 ( ( -LRB- cord-005453-4057qib7 2035 9 34 34 CD cord-005453-4057qib7 2035 10 % % NN cord-005453-4057qib7 2035 11 ) ) -RRB- cord-005453-4057qib7 2035 12 , , , cord-005453-4057qib7 2035 13 reduced reduce VBN cord-005453-4057qib7 2035 14 intensity intensity NN cord-005453-4057qib7 2035 15 regimens regimen NNS cord-005453-4057qib7 2035 16 in in IN cord-005453-4057qib7 2035 17 105 105 CD cord-005453-4057qib7 2035 18 ( ( -LRB- cord-005453-4057qib7 2035 19 66 66 CD cord-005453-4057qib7 2035 20 % % NN cord-005453-4057qib7 2035 21 ) ) -RRB- cord-005453-4057qib7 2035 22 patients patient NNS cord-005453-4057qib7 2035 23 . . . cord-005453-4057qib7 2036 1 PTCy PTCy NNS cord-005453-4057qib7 2036 2 combined combine VBN cord-005453-4057qib7 2036 3 with with IN cord-005453-4057qib7 2036 4 ATG ATG NNP cord-005453-4057qib7 2036 5 was be VBD cord-005453-4057qib7 2036 6 used use VBN cord-005453-4057qib7 2036 7 in in IN cord-005453-4057qib7 2036 8 69 69 CD cord-005453-4057qib7 2036 9 ( ( -LRB- cord-005453-4057qib7 2036 10 43 43 CD cord-005453-4057qib7 2036 11 % % NN cord-005453-4057qib7 2036 12 ) ) -RRB- cord-005453-4057qib7 2036 13 patients patient NNS cord-005453-4057qib7 2036 14 , , , cord-005453-4057qib7 2037 1 other other JJ cord-005453-4057qib7 2037 2 GvHD GvHD NNP cord-005453-4057qib7 2037 3 prophylaxis prophylaxis NN cord-005453-4057qib7 2037 4 regimens regimen NNS cord-005453-4057qib7 2037 5 were be VBD cord-005453-4057qib7 2037 6 used use VBN cord-005453-4057qib7 2037 7 in in IN cord-005453-4057qib7 2037 8 90 90 CD cord-005453-4057qib7 2037 9 ( ( -LRB- cord-005453-4057qib7 2037 10 57 57 CD cord-005453-4057qib7 2037 11 % % NN cord-005453-4057qib7 2037 12 ) ) -RRB- cord-005453-4057qib7 2037 13 patients patient NNS cord-005453-4057qib7 2037 14 . . . cord-005453-4057qib7 2038 1 Both both DT cord-005453-4057qib7 2038 2 donor donor NN cord-005453-4057qib7 2038 3 and and CC cord-005453-4057qib7 2038 4 recipient recipient NN cord-005453-4057qib7 2038 5 were be VBD cord-005453-4057qib7 2038 6 CMV CMV NNP cord-005453-4057qib7 2038 7 negative negative JJ cord-005453-4057qib7 2038 8 in in IN cord-005453-4057qib7 2038 9 18 18 CD cord-005453-4057qib7 2038 10 ( ( -LRB- cord-005453-4057qib7 2038 11 11 11 CD cord-005453-4057qib7 2038 12 % % NN cord-005453-4057qib7 2038 13 ) ) -RRB- cord-005453-4057qib7 2038 14 patients patient NNS cord-005453-4057qib7 2038 15 . . . cord-005453-4057qib7 2039 1 Median median JJ cord-005453-4057qib7 2039 2 follow follow NN cord-005453-4057qib7 2039 3 - - HYPH cord-005453-4057qib7 2039 4 up up NN cord-005453-4057qib7 2039 5 of of IN cord-005453-4057qib7 2039 6 survivors survivor NNS cord-005453-4057qib7 2039 7 was be VBD cord-005453-4057qib7 2039 8 29 29 CD cord-005453-4057qib7 2039 9 months month NNS cord-005453-4057qib7 2040 1 ( ( -LRB- cord-005453-4057qib7 2040 2 range range NNP cord-005453-4057qib7 2040 3 14 14 CD cord-005453-4057qib7 2040 4 - - SYM cord-005453-4057qib7 2040 5 56 56 CD cord-005453-4057qib7 2040 6 months month NNS cord-005453-4057qib7 2040 7 ) ) -RRB- cord-005453-4057qib7 2040 8 . . . cord-005453-4057qib7 2041 1 Univariate Univariate NNP cord-005453-4057qib7 2041 2 analysis analysis NN cord-005453-4057qib7 2041 3 demonstrated demonstrate VBD cord-005453-4057qib7 2041 4 OS OS NNP cord-005453-4057qib7 2041 5 of of IN cord-005453-4057qib7 2041 6 the the DT cord-005453-4057qib7 2041 7 entire entire JJ cord-005453-4057qib7 2041 8 cohort cohort NN cord-005453-4057qib7 2041 9 at at IN cord-005453-4057qib7 2041 10 2 2 CD cord-005453-4057qib7 2041 11 years year NNS cord-005453-4057qib7 2041 12 was be VBD cord-005453-4057qib7 2041 13 49 49 CD cord-005453-4057qib7 2041 14 % % NN cord-005453-4057qib7 2041 15 ( ( -LRB- cord-005453-4057qib7 2041 16 95%CI 95%ci CD cord-005453-4057qib7 2041 17 41 41 CD cord-005453-4057qib7 2041 18 - - SYM cord-005453-4057qib7 2041 19 57 57 CD cord-005453-4057qib7 2041 20 % % NN cord-005453-4057qib7 2041 21 ) ) -RRB- cord-005453-4057qib7 2041 22 , , , cord-005453-4057qib7 2041 23 CIR CIR NNP cord-005453-4057qib7 2041 24 at at IN cord-005453-4057qib7 2041 25 2 2 CD cord-005453-4057qib7 2041 26 years year NNS cord-005453-4057qib7 2041 27 was be VBD cord-005453-4057qib7 2041 28 22 22 CD cord-005453-4057qib7 2041 29 % % NN cord-005453-4057qib7 2041 30 ( ( -LRB- cord-005453-4057qib7 2041 31 95%CI 95%ci CD cord-005453-4057qib7 2041 32 16 16 CD cord-005453-4057qib7 2041 33 - - SYM cord-005453-4057qib7 2041 34 29 29 CD cord-005453-4057qib7 2041 35 % % NN cord-005453-4057qib7 2041 36 ) ) -RRB- cord-005453-4057qib7 2041 37 and and CC cord-005453-4057qib7 2041 38 NRM NRM NNP cord-005453-4057qib7 2041 39 at at IN cord-005453-4057qib7 2041 40 2 2 CD cord-005453-4057qib7 2041 41 years year NNS cord-005453-4057qib7 2041 42 was be VBD cord-005453-4057qib7 2041 43 32 32 CD cord-005453-4057qib7 2041 44 % % NN cord-005453-4057qib7 2041 45 ( ( -LRB- cord-005453-4057qib7 2041 46 95%CI 95%ci CD cord-005453-4057qib7 2041 47 25 25 CD cord-005453-4057qib7 2041 48 - - SYM cord-005453-4057qib7 2041 49 39 39 CD cord-005453-4057qib7 2041 50 % % NN cord-005453-4057qib7 2041 51 ) ) -RRB- cord-005453-4057qib7 2041 52 . . . cord-005453-4057qib7 2042 1 Concerning concern VBG cord-005453-4057qib7 2042 2 GvHD GvHD NNP cord-005453-4057qib7 2042 3 prophylaxis prophylaxis NN cord-005453-4057qib7 2042 4 regimen regimen NN cord-005453-4057qib7 2042 5 , , , cord-005453-4057qib7 2042 6 2-year 2-year JJ cord-005453-4057qib7 2042 7 OS os NN cord-005453-4057qib7 2042 8 for for IN cord-005453-4057qib7 2042 9 PTCy PTCy NNS cord-005453-4057qib7 2042 10 / / SYM cord-005453-4057qib7 2042 11 ATG ATG NNP cord-005453-4057qib7 2042 12 versus versus IN cord-005453-4057qib7 2042 13 others other NNS cord-005453-4057qib7 2042 14 was be VBD cord-005453-4057qib7 2042 15 46 46 CD cord-005453-4057qib7 2042 16 % % NN cord-005453-4057qib7 2042 17 ( ( -LRB- cord-005453-4057qib7 2042 18 95%CI 95%ci CD cord-005453-4057qib7 2042 19 33 33 CD cord-005453-4057qib7 2042 20 - - SYM cord-005453-4057qib7 2042 21 58 58 CD cord-005453-4057qib7 2042 22 % % NN cord-005453-4057qib7 2042 23 ) ) -RRB- cord-005453-4057qib7 2042 24 versus versus IN cord-005453-4057qib7 2042 25 51 51 CD cord-005453-4057qib7 2042 26 % % NN cord-005453-4057qib7 2042 27 ( ( -LRB- cord-005453-4057qib7 2042 28 95%CI 95%ci CD cord-005453-4057qib7 2042 29 40 40 CD cord-005453-4057qib7 2042 30 - - SYM cord-005453-4057qib7 2042 31 61 61 CD cord-005453-4057qib7 2042 32 % % NN cord-005453-4057qib7 2042 33 ) ) -RRB- cord-005453-4057qib7 2042 34 ( ( -LRB- cord-005453-4057qib7 2042 35 p=0.87 p=0.87 NNP cord-005453-4057qib7 2042 36 , , , cord-005453-4057qib7 2042 37 Figure figure NN cord-005453-4057qib7 2042 38 ) ) -RRB- cord-005453-4057qib7 2042 39 , , , cord-005453-4057qib7 2042 40 2-year 2-year CD cord-005453-4057qib7 2042 41 CIR CIR NNP cord-005453-4057qib7 2042 42 for for IN cord-005453-4057qib7 2042 43 PTCy PTCy NNPS cord-005453-4057qib7 2042 44 / / SYM cord-005453-4057qib7 2042 45 ATG ATG NNP cord-005453-4057qib7 2042 46 versus versus IN cord-005453-4057qib7 2042 47 other other JJ cord-005453-4057qib7 2042 48 was be VBD cord-005453-4057qib7 2042 49 31 31 CD cord-005453-4057qib7 2042 50 % % NN cord-005453-4057qib7 2042 51 ( ( -LRB- cord-005453-4057qib7 2042 52 95%CI 95%ci CD cord-005453-4057qib7 2042 53 20 20 CD cord-005453-4057qib7 2042 54 - - SYM cord-005453-4057qib7 2042 55 43 43 CD cord-005453-4057qib7 2042 56 % % NN cord-005453-4057qib7 2042 57 ) ) -RRB- cord-005453-4057qib7 2042 58 versus versus IN cord-005453-4057qib7 2042 59 16 16 CD cord-005453-4057qib7 2042 60 % % NN cord-005453-4057qib7 2042 61 ( ( -LRB- cord-005453-4057qib7 2042 62 95%CI 95%ci CD cord-005453-4057qib7 2042 63 9 9 CD cord-005453-4057qib7 2042 64 - - SYM cord-005453-4057qib7 2042 65 24 24 CD cord-005453-4057qib7 2042 66 % % NN cord-005453-4057qib7 2042 67 ) ) -RRB- cord-005453-4057qib7 2043 1 ( ( -LRB- cord-005453-4057qib7 2043 2 p=0.02 p=0.02 NNP cord-005453-4057qib7 2043 3 ) ) -RRB- cord-005453-4057qib7 2043 4 and and CC cord-005453-4057qib7 2043 5 2-year 2-year CD cord-005453-4057qib7 2043 6 NRM NRM NNP cord-005453-4057qib7 2043 7 for for IN cord-005453-4057qib7 2043 8 PTCy PTCy NNPS cord-005453-4057qib7 2043 9 versus versus IN cord-005453-4057qib7 2043 10 other other JJ cord-005453-4057qib7 2043 11 was be VBD cord-005453-4057qib7 2043 12 28 28 CD cord-005453-4057qib7 2043 13 % % NN cord-005453-4057qib7 2043 14 ( ( -LRB- cord-005453-4057qib7 2043 15 95%CI 95%ci CD cord-005453-4057qib7 2043 16 18 18 CD cord-005453-4057qib7 2043 17 - - SYM cord-005453-4057qib7 2043 18 39 39 CD cord-005453-4057qib7 2043 19 % % NN cord-005453-4057qib7 2043 20 ) ) -RRB- cord-005453-4057qib7 2043 21 versus versus IN cord-005453-4057qib7 2043 22 34 34 CD cord-005453-4057qib7 2043 23 % % NN cord-005453-4057qib7 2043 24 ( ( -LRB- cord-005453-4057qib7 2043 25 95%CI 95%ci CD cord-005453-4057qib7 2043 26 25 25 CD cord-005453-4057qib7 2043 27 - - SYM cord-005453-4057qib7 2043 28 44 44 CD cord-005453-4057qib7 2043 29 % % NN cord-005453-4057qib7 2043 30 ) ) -RRB- cord-005453-4057qib7 2044 1 ( ( -LRB- cord-005453-4057qib7 2044 2 p=0.35 p=0.35 NNP cord-005453-4057qib7 2044 3 ) ) -RRB- cord-005453-4057qib7 2044 4 . . . cord-005453-4057qib7 2045 1 Grade Grade NNP cord-005453-4057qib7 2045 2 II II NNP cord-005453-4057qib7 2045 3 - - HYPH cord-005453-4057qib7 2045 4 IV IV NNP cord-005453-4057qib7 2045 5 acute acute JJ cord-005453-4057qib7 2045 6 GvHD GvHD NNP cord-005453-4057qib7 2045 7 was be VBD cord-005453-4057qib7 2045 8 seen see VBN cord-005453-4057qib7 2045 9 in in IN cord-005453-4057qib7 2045 10 23 23 CD cord-005453-4057qib7 2045 11 % % NN cord-005453-4057qib7 2045 12 of of IN cord-005453-4057qib7 2045 13 PTCy PTCy NNS cord-005453-4057qib7 2045 14 / / SYM cord-005453-4057qib7 2045 15 ATG ATG NNP cord-005453-4057qib7 2045 16 patients patient NNS cord-005453-4057qib7 2045 17 versus versus IN cord-005453-4057qib7 2045 18 59 59 CD cord-005453-4057qib7 2045 19 % % NN cord-005453-4057qib7 2045 20 using use VBG cord-005453-4057qib7 2045 21 other other JJ cord-005453-4057qib7 2045 22 regimens regimen NNS cord-005453-4057qib7 2045 23 ( ( -LRB- cord-005453-4057qib7 2045 24 p p NN cord-005453-4057qib7 2045 25 < < XX cord-005453-4057qib7 2045 26 0.0001 0.0001 CD cord-005453-4057qib7 2045 27 ) ) -RRB- cord-005453-4057qib7 2045 28 . . . cord-005453-4057qib7 2046 1 Chronic chronic JJ cord-005453-4057qib7 2046 2 GvHD GvHD NNP cord-005453-4057qib7 2046 3 was be VBD cord-005453-4057qib7 2046 4 observed observe VBN cord-005453-4057qib7 2046 5 in in IN cord-005453-4057qib7 2046 6 20 20 CD cord-005453-4057qib7 2046 7 % % NN cord-005453-4057qib7 2046 8 of of IN cord-005453-4057qib7 2046 9 PTCy PTCy NNS cord-005453-4057qib7 2046 10 / / SYM cord-005453-4057qib7 2046 11 ATG ATG NNP cord-005453-4057qib7 2046 12 patients patient NNS cord-005453-4057qib7 2046 13 versus versus IN cord-005453-4057qib7 2046 14 42 42 CD cord-005453-4057qib7 2046 15 % % NN cord-005453-4057qib7 2046 16 using use VBG cord-005453-4057qib7 2046 17 other other JJ cord-005453-4057qib7 2046 18 regimens regimen NNS cord-005453-4057qib7 2046 19 ( ( -LRB- cord-005453-4057qib7 2046 20 p=0.004 p=0.004 NNP cord-005453-4057qib7 2046 21 ) ) -RRB- cord-005453-4057qib7 2046 22 . . . cord-005453-4057qib7 2047 1 Multivariable multivariable JJ cord-005453-4057qib7 2047 2 analysis analysis NN cord-005453-4057qib7 2047 3 for for IN cord-005453-4057qib7 2047 4 OS OS NNP cord-005453-4057qib7 2047 5 confirmed confirm VBD cord-005453-4057qib7 2047 6 that that IN cord-005453-4057qib7 2047 7 the the DT cord-005453-4057qib7 2047 8 GvHD GvHD NNP cord-005453-4057qib7 2047 9 prophylaxis prophylaxis NN cord-005453-4057qib7 2047 10 regimen regimen NN cord-005453-4057qib7 2047 11 has have VBZ cord-005453-4057qib7 2047 12 no no DT cord-005453-4057qib7 2047 13 influence influence NN cord-005453-4057qib7 2047 14 ( ( -LRB- cord-005453-4057qib7 2047 15 p=0.19 p=0.19 NNP cord-005453-4057qib7 2047 16 ) ) -RRB- cord-005453-4057qib7 2047 17 , , , cord-005453-4057qib7 2047 18 while while IN cord-005453-4057qib7 2047 19 the the DT cord-005453-4057qib7 2047 20 predominant predominant JJ cord-005453-4057qib7 2047 21 predictor predictor NN cord-005453-4057qib7 2047 22 of of IN cord-005453-4057qib7 2047 23 survival survival NN cord-005453-4057qib7 2047 24 was be VBD cord-005453-4057qib7 2047 25 age age NN cord-005453-4057qib7 2047 26 at at IN cord-005453-4057qib7 2047 27 HCT HCT NNP cord-005453-4057qib7 2047 28 ( ( -LRB- cord-005453-4057qib7 2047 29 HR HR NNP cord-005453-4057qib7 2047 30 1.03 1.03 CD cord-005453-4057qib7 2047 31 , , , cord-005453-4057qib7 2047 32 95%CI 95%ci CD cord-005453-4057qib7 2047 33 1.01 1.01 CD cord-005453-4057qib7 2047 34 - - SYM cord-005453-4057qib7 2047 35 1.05 1.05 CD cord-005453-4057qib7 2047 36 , , , cord-005453-4057qib7 2047 37 p=0.01 p=0.01 NNP cord-005453-4057qib7 2047 38 ) ) -RRB- cord-005453-4057qib7 2047 39 . . . cord-005453-4057qib7 2048 1 For for IN cord-005453-4057qib7 2048 2 CIR CIR NNP cord-005453-4057qib7 2048 3 , , , cord-005453-4057qib7 2048 4 the the DT cord-005453-4057qib7 2048 5 PTCy PTCy NNPS cord-005453-4057qib7 2048 6 / / SYM cord-005453-4057qib7 2048 7 ATG ATG NNP cord-005453-4057qib7 2048 8 combination combination NN cord-005453-4057qib7 2048 9 had have VBD cord-005453-4057qib7 2048 10 no no DT cord-005453-4057qib7 2048 11 influence influence NN cord-005453-4057qib7 2048 12 compared compare VBN cord-005453-4057qib7 2048 13 to to IN cord-005453-4057qib7 2048 14 other other JJ cord-005453-4057qib7 2048 15 GvHD gvhd NN cord-005453-4057qib7 2048 16 prophylaxis prophylaxis NN cord-005453-4057qib7 2048 17 regimens regimen NNS cord-005453-4057qib7 2048 18 ( ( -LRB- cord-005453-4057qib7 2048 19 p=0.6 p=0.6 NNP cord-005453-4057qib7 2048 20 ) ) -RRB- cord-005453-4057qib7 2048 21 , , , cord-005453-4057qib7 2048 22 while while IN cord-005453-4057qib7 2048 23 RIC RIC NNP cord-005453-4057qib7 2048 24 conditioning conditioning NN cord-005453-4057qib7 2048 25 was be VBD cord-005453-4057qib7 2048 26 the the DT cord-005453-4057qib7 2048 27 predominant predominant JJ cord-005453-4057qib7 2048 28 predictor predictor NN cord-005453-4057qib7 2048 29 of of IN cord-005453-4057qib7 2048 30 relapse relapse NN cord-005453-4057qib7 2048 31 ( ( -LRB- cord-005453-4057qib7 2048 32 HR HR NNP cord-005453-4057qib7 2048 33 3.05 3.05 CD cord-005453-4057qib7 2048 34 for for IN cord-005453-4057qib7 2048 35 RIC RIC NNP cord-005453-4057qib7 2048 36 , , , cord-005453-4057qib7 2048 37 95 95 CD cord-005453-4057qib7 2048 38 % % NN cord-005453-4057qib7 2048 39 p=0.01 p=0.01 NNP cord-005453-4057qib7 2048 40 ) ) -RRB- cord-005453-4057qib7 2048 41 . . . cord-005453-4057qib7 2049 1 For for IN cord-005453-4057qib7 2049 2 NRM NRM NNP cord-005453-4057qib7 2049 3 , , , cord-005453-4057qib7 2049 4 the the DT cord-005453-4057qib7 2049 5 ATG ATG NNP cord-005453-4057qib7 2049 6 with with IN cord-005453-4057qib7 2049 7 PTCy PTCy NNP cord-005453-4057qib7 2049 8 combination combination NN cord-005453-4057qib7 2049 9 demonstrated demonstrate VBD cord-005453-4057qib7 2049 10 no no DT cord-005453-4057qib7 2049 11 significant significant JJ cord-005453-4057qib7 2049 12 difference difference NN cord-005453-4057qib7 2049 13 ( ( -LRB- cord-005453-4057qib7 2049 14 p=0.12 p=0.12 NNP cord-005453-4057qib7 2049 15 ) ) -RRB- cord-005453-4057qib7 2049 16 , , , cord-005453-4057qib7 2049 17 while while IN cord-005453-4057qib7 2049 18 age age NN cord-005453-4057qib7 2049 19 at at IN cord-005453-4057qib7 2049 20 HCT HCT NNP cord-005453-4057qib7 2049 21 was be VBD cord-005453-4057qib7 2049 22 the the DT cord-005453-4057qib7 2049 23 predominant predominant JJ cord-005453-4057qib7 2049 24 predictor predictor NN cord-005453-4057qib7 2049 25 ( ( -LRB- cord-005453-4057qib7 2049 26 HR=1.04 HR=1.04 NNP cord-005453-4057qib7 2049 27 , , , cord-005453-4057qib7 2049 28 95%CI 95%ci CD cord-005453-4057qib7 2049 29 1.01 1.01 CD cord-005453-4057qib7 2049 30 - - SYM cord-005453-4057qib7 2049 31 1.07 1.07 CD cord-005453-4057qib7 2049 32 , , , cord-005453-4057qib7 2049 33 p=0.02 p=0.02 NNP cord-005453-4057qib7 2049 34 ) ) -RRB- cord-005453-4057qib7 2049 35 . . . cord-005453-4057qib7 2050 1 Conclusions conclusion NNS cord-005453-4057qib7 2050 2 : : : cord-005453-4057qib7 2051 1 The the DT cord-005453-4057qib7 2051 2 PTCy PTCy NNPS cord-005453-4057qib7 2051 3 / / SYM cord-005453-4057qib7 2051 4 ATG ATG NNP cord-005453-4057qib7 2051 5 combination combination NN cord-005453-4057qib7 2051 6 for for IN cord-005453-4057qib7 2051 7 GvHD GvHD NNP cord-005453-4057qib7 2051 8 prophylaxis prophylaxis NN cord-005453-4057qib7 2051 9 has have VBZ cord-005453-4057qib7 2051 10 demonstrated demonstrate VBN cord-005453-4057qib7 2051 11 on on IN cord-005453-4057qib7 2051 12 multivariable multivariable JJ cord-005453-4057qib7 2051 13 analysis analysis NN cord-005453-4057qib7 2051 14 similar similar JJ cord-005453-4057qib7 2051 15 OS OS NNP cord-005453-4057qib7 2051 16 , , , cord-005453-4057qib7 2051 17 CIR CIR NNP cord-005453-4057qib7 2051 18 and and CC cord-005453-4057qib7 2051 19 NRM NRM NNP cord-005453-4057qib7 2051 20 with with IN cord-005453-4057qib7 2051 21 other other JJ cord-005453-4057qib7 2051 22 previously previously RB cord-005453-4057qib7 2051 23 used use VBN cord-005453-4057qib7 2051 24 regimens regimen NNS cord-005453-4057qib7 2051 25 at at IN cord-005453-4057qib7 2051 26 our -PRON- PRP$ cord-005453-4057qib7 2051 27 center center NN cord-005453-4057qib7 2051 28 . . . cord-005453-4057qib7 2052 1 A a DT cord-005453-4057qib7 2052 2 decrease decrease NN cord-005453-4057qib7 2052 3 in in IN cord-005453-4057qib7 2052 4 ATG ATG NNP cord-005453-4057qib7 2052 5 dose dose NN cord-005453-4057qib7 2052 6 may may MD cord-005453-4057qib7 2052 7 potentially potentially RB cord-005453-4057qib7 2052 8 decrease decrease VB cord-005453-4057qib7 2052 9 the the DT cord-005453-4057qib7 2052 10 relapse relapse NN cord-005453-4057qib7 2052 11 rate rate NN cord-005453-4057qib7 2052 12 while while IN cord-005453-4057qib7 2052 13 retaining retain VBG cord-005453-4057qib7 2052 14 the the DT cord-005453-4057qib7 2052 15 advantage advantage NN cord-005453-4057qib7 2052 16 of of IN cord-005453-4057qib7 2052 17 decreased decreased JJ cord-005453-4057qib7 2052 18 GvHD GvHD NNP cord-005453-4057qib7 2052 19 . . . cord-005453-4057qib7 2053 1 [ [ -LRB- cord-005453-4057qib7 2053 2 _SP cord-005453-4057qib7 2053 3 Background Background NNP cord-005453-4057qib7 2053 4 : : : cord-005453-4057qib7 2054 1 The the DT cord-005453-4057qib7 2054 2 combination combination NN cord-005453-4057qib7 2054 3 of of IN cord-005453-4057qib7 2054 4 fludarabine fludarabine NN cord-005453-4057qib7 2054 5 with with IN cord-005453-4057qib7 2054 6 myeloablative myeloablative JJ cord-005453-4057qib7 2054 7 doses dose NNS cord-005453-4057qib7 2054 8 of of IN cord-005453-4057qib7 2054 9 busulfan busulfan NNP cord-005453-4057qib7 2054 10 ( ( -LRB- cord-005453-4057qib7 2054 11 FB4 FB4 NNP cord-005453-4057qib7 2054 12 ) ) -RRB- cord-005453-4057qib7 2054 13 represents represent VBZ cord-005453-4057qib7 2054 14 a a DT cord-005453-4057qib7 2054 15 standard standard NN cord-005453-4057qib7 2054 16 of of IN cord-005453-4057qib7 2054 17 care care NN cord-005453-4057qib7 2054 18 conditioning conditioning NN cord-005453-4057qib7 2054 19 regimen regimen NN cord-005453-4057qib7 2054 20 before before IN cord-005453-4057qib7 2054 21 allogeneic allogeneic NN cord-005453-4057qib7 2054 22 transplantation transplantation NN cord-005453-4057qib7 2054 23 in in IN cord-005453-4057qib7 2054 24 patients patient NNS cord-005453-4057qib7 2054 25 with with IN cord-005453-4057qib7 2054 26 myeloid myeloid JJ cord-005453-4057qib7 2054 27 malignancies malignancy NNS cord-005453-4057qib7 2054 28 ( ( -LRB- cord-005453-4057qib7 2054 29 Giralt Giralt NNP cord-005453-4057qib7 2054 30 , , , cord-005453-4057qib7 2054 31 S. S. NNP cord-005453-4057qib7 2054 32 : : : cord-005453-4057qib7 2054 33 The the DT cord-005453-4057qib7 2054 34 Lancet Lancet NNP cord-005453-4057qib7 2054 35 Oncology Oncology NNP cord-005453-4057qib7 2054 36 2015 2015 CD cord-005453-4057qib7 2054 37 ) ) -RRB- cord-005453-4057qib7 2054 38 . . . cord-005453-4057qib7 2055 1 FB4 FB4 NNP cord-005453-4057qib7 2055 2 has have VBZ cord-005453-4057qib7 2055 3 potent potent JJ cord-005453-4057qib7 2055 4 antileukemic antileukemic JJ cord-005453-4057qib7 2055 5 activity activity NN cord-005453-4057qib7 2055 6 and and CC cord-005453-4057qib7 2055 7 is be VBZ cord-005453-4057qib7 2055 8 associated associate VBN cord-005453-4057qib7 2055 9 with with IN cord-005453-4057qib7 2055 10 low low JJ cord-005453-4057qib7 2055 11 transplantrelated transplantrelated JJ cord-005453-4057qib7 2055 12 mortality mortality NN cord-005453-4057qib7 2055 13 and and CC cord-005453-4057qib7 2055 14 acute acute JJ cord-005453-4057qib7 2055 15 GvHD gvhd NN cord-005453-4057qib7 2055 16 . . . cord-005453-4057qib7 2056 1 However however RB cord-005453-4057qib7 2056 2 , , , cord-005453-4057qib7 2056 3 early early RB cord-005453-4057qib7 2056 4 after after IN cord-005453-4057qib7 2056 5 transplantation transplantation NN cord-005453-4057qib7 2056 6 ( ( -LRB- cord-005453-4057qib7 2056 7 days day NNS cord-005453-4057qib7 2056 8 30 30 CD cord-005453-4057qib7 2056 9 - - SYM cord-005453-4057qib7 2056 10 90 90 CD cord-005453-4057qib7 2056 11 ) ) -RRB- cord-005453-4057qib7 2056 12 , , , cord-005453-4057qib7 2056 13 a a DT cord-005453-4057qib7 2056 14 proportion proportion NN cord-005453-4057qib7 2056 15 of of IN cord-005453-4057qib7 2056 16 patients patient NNS cord-005453-4057qib7 2056 17 may may MD cord-005453-4057qib7 2056 18 not not RB cord-005453-4057qib7 2056 19 convert convert VB cord-005453-4057qib7 2056 20 to to IN cord-005453-4057qib7 2056 21 a a DT cord-005453-4057qib7 2056 22 full full JJ cord-005453-4057qib7 2056 23 donor donor NN cord-005453-4057qib7 2056 24 haemopoietic haemopoietic NN cord-005453-4057qib7 2056 25 chimerism chimerism NN cord-005453-4057qib7 2056 26 , , , cord-005453-4057qib7 2056 27 particularly particularly RB cord-005453-4057qib7 2056 28 if if IN cord-005453-4057qib7 2056 29 anti anti JJ cord-005453-4057qib7 2056 30 - - JJ cord-005453-4057qib7 2056 31 T t JJ cord-005453-4057qib7 2056 32 lymphocyte lymphocyte NN cord-005453-4057qib7 2056 33 globulin globulin NN cord-005453-4057qib7 2056 34 ( ( -LRB- cord-005453-4057qib7 2056 35 ATG ATG NNP cord-005453-4057qib7 2056 36 ) ) -RRB- cord-005453-4057qib7 2056 37 is be VBZ cord-005453-4057qib7 2056 38 used use VBN cord-005453-4057qib7 2056 39 as as IN cord-005453-4057qib7 2056 40 GvHD GvHD NNP cord-005453-4057qib7 2056 41 prophylaxis prophylaxis NN cord-005453-4057qib7 2056 42 ( ( -LRB- cord-005453-4057qib7 2056 43 Rambaldi Rambaldi NNP cord-005453-4057qib7 2056 44 A A NNP cord-005453-4057qib7 2056 45 , , , cord-005453-4057qib7 2056 46 et et NNP cord-005453-4057qib7 2056 47 al al NNP cord-005453-4057qib7 2056 48 . . NNP cord-005453-4057qib7 2056 49 : : : cord-005453-4057qib7 2057 1 The the DT cord-005453-4057qib7 2057 2 Lancet Lancet NNP cord-005453-4057qib7 2057 3 Oncology Oncology NNP cord-005453-4057qib7 2057 4 2015 2015 CD cord-005453-4057qib7 2057 5 ) ) -RRB- cord-005453-4057qib7 2058 1 Methods method NNS cord-005453-4057qib7 2059 1 : : : cord-005453-4057qib7 2059 2 We -PRON- PRP cord-005453-4057qib7 2059 3 retrospective retrospective VBP cord-005453-4057qib7 2059 4 analyzed analyze VBD cord-005453-4057qib7 2059 5 104 104 CD cord-005453-4057qib7 2059 6 patients patient NNS cord-005453-4057qib7 2059 7 who who WP cord-005453-4057qib7 2059 8 underwent undergo VBD cord-005453-4057qib7 2059 9 an an DT cord-005453-4057qib7 2059 10 allogeneic allogeneic NN cord-005453-4057qib7 2059 11 stem stem NN cord-005453-4057qib7 2059 12 cell cell NN cord-005453-4057qib7 2059 13 transplantation transplantation NN cord-005453-4057qib7 2059 14 after after IN cord-005453-4057qib7 2059 15 FB4 FB4 NNP cord-005453-4057qib7 2059 16 conditioning conditioning NN cord-005453-4057qib7 2059 17 regimen regimen NN cord-005453-4057qib7 2059 18 at at IN cord-005453-4057qib7 2059 19 our -PRON- PRP$ cord-005453-4057qib7 2059 20 hospital hospital NN cord-005453-4057qib7 2059 21 , , , cord-005453-4057qib7 2059 22 from from IN cord-005453-4057qib7 2059 23 November November NNP cord-005453-4057qib7 2059 24 2007 2007 CD cord-005453-4057qib7 2059 25 to to IN cord-005453-4057qib7 2059 26 August August NNP cord-005453-4057qib7 2059 27 2018 2018 CD cord-005453-4057qib7 2059 28 . . . cord-005453-4057qib7 2060 1 The the DT cord-005453-4057qib7 2060 2 median median JJ cord-005453-4057qib7 2060 3 age age NN cord-005453-4057qib7 2060 4 was be VBD cord-005453-4057qib7 2060 5 51 51 CD cord-005453-4057qib7 2060 6 years year NNS cord-005453-4057qib7 2061 1 ( ( -LRB- cord-005453-4057qib7 2061 2 range range NNP cord-005453-4057qib7 2061 3 22 22 CD cord-005453-4057qib7 2061 4 - - SYM cord-005453-4057qib7 2061 5 67 67 CD cord-005453-4057qib7 2061 6 ) ) -RRB- cord-005453-4057qib7 2061 7 and and CC cord-005453-4057qib7 2061 8 diagnoses diagnosis NNS cord-005453-4057qib7 2061 9 were be VBD cord-005453-4057qib7 2061 10 AML AML NNP cord-005453-4057qib7 2061 11 76 76 CD cord-005453-4057qib7 2061 12 % % NN cord-005453-4057qib7 2061 13 , , , cord-005453-4057qib7 2061 14 MDS MDS NNP cord-005453-4057qib7 2061 15 18 18 CD cord-005453-4057qib7 2061 16 % % NN cord-005453-4057qib7 2061 17 CML CML NNP cord-005453-4057qib7 2061 18 5 5 CD cord-005453-4057qib7 2061 19 % % NN cord-005453-4057qib7 2061 20 MFI MFI NNP cord-005453-4057qib7 2061 21 1 1 CD cord-005453-4057qib7 2061 22 % % NN cord-005453-4057qib7 2061 23 ) ) -RRB- cord-005453-4057qib7 2061 24 . . . cord-005453-4057qib7 2062 1 The the DT cord-005453-4057qib7 2062 2 disease disease NN cord-005453-4057qib7 2062 3 status status NN cord-005453-4057qib7 2062 4 at at IN cord-005453-4057qib7 2062 5 transplantation transplantation NN cord-005453-4057qib7 2062 6 was be VBD cord-005453-4057qib7 2062 7 : : : cord-005453-4057qib7 2062 8 CR1 CR1 NNP cord-005453-4057qib7 2062 9 in in IN cord-005453-4057qib7 2062 10 59 59 CD cord-005453-4057qib7 2062 11 % % NN cord-005453-4057qib7 2062 12 , , , cord-005453-4057qib7 2062 13 CR2 CR2 NNP cord-005453-4057qib7 2062 14 in in IN cord-005453-4057qib7 2062 15 5 5 CD cord-005453-4057qib7 2062 16 % % NN cord-005453-4057qib7 2062 17 and and CC cord-005453-4057qib7 2062 18 active active JJ cord-005453-4057qib7 2062 19 disease disease NN cord-005453-4057qib7 2062 20 in in IN cord-005453-4057qib7 2062 21 36 36 CD cord-005453-4057qib7 2062 22 % % NN cord-005453-4057qib7 2062 23 of of IN cord-005453-4057qib7 2062 24 patients patient NNS cord-005453-4057qib7 2062 25 . . . cord-005453-4057qib7 2063 1 The the DT cord-005453-4057qib7 2063 2 stem stem NN cord-005453-4057qib7 2063 3 cell cell NN cord-005453-4057qib7 2063 4 source source NN cord-005453-4057qib7 2063 5 was be VBD cord-005453-4057qib7 2063 6 represented represent VBN cord-005453-4057qib7 2063 7 by by IN cord-005453-4057qib7 2063 8 PBSC PBSC NNP cord-005453-4057qib7 2063 9 in in IN cord-005453-4057qib7 2063 10 more more JJR cord-005453-4057qib7 2063 11 than than IN cord-005453-4057qib7 2063 12 95 95 CD cord-005453-4057qib7 2063 13 % % NN cord-005453-4057qib7 2063 14 of of IN cord-005453-4057qib7 2063 15 cases case NNS cord-005453-4057qib7 2063 16 and and CC cord-005453-4057qib7 2063 17 anti anti JJ cord-005453-4057qib7 2063 18 - - JJ cord-005453-4057qib7 2063 19 T t JJ cord-005453-4057qib7 2063 20 lymphocyte lymphocyte NN cord-005453-4057qib7 2063 21 globulin globulin NN cord-005453-4057qib7 2063 22 ( ( -LRB- cord-005453-4057qib7 2063 23 ATG ATG NNP cord-005453-4057qib7 2063 24 ) ) -RRB- cord-005453-4057qib7 2064 1 was be VBD cord-005453-4057qib7 2064 2 part part NN cord-005453-4057qib7 2064 3 of of IN cord-005453-4057qib7 2064 4 the the DT cord-005453-4057qib7 2064 5 conditioning conditioning NN cord-005453-4057qib7 2064 6 regimen regimen NN cord-005453-4057qib7 2064 7 in in IN cord-005453-4057qib7 2064 8 more more JJR cord-005453-4057qib7 2064 9 than than IN cord-005453-4057qib7 2064 10 95 95 CD cord-005453-4057qib7 2064 11 % % NN cord-005453-4057qib7 2064 12 of of IN cord-005453-4057qib7 2064 13 cases case NNS cord-005453-4057qib7 2064 14 at at IN cord-005453-4057qib7 2064 15 a a DT cord-005453-4057qib7 2064 16 dose dose NN cord-005453-4057qib7 2064 17 of of IN cord-005453-4057qib7 2064 18 5 5 CD cord-005453-4057qib7 2064 19 mg mg NNP cord-005453-4057qib7 2064 20 / / SYM cord-005453-4057qib7 2064 21 Kg Kg NNP cord-005453-4057qib7 2064 22 . . . cord-005453-4057qib7 2065 1 The the DT cord-005453-4057qib7 2065 2 donor donor NN cord-005453-4057qib7 2065 3 was be VBD cord-005453-4057qib7 2065 4 a a DT cord-005453-4057qib7 2065 5 HLA HLA NNP cord-005453-4057qib7 2065 6 identical identical JJ cord-005453-4057qib7 2065 7 sibling sibling NN cord-005453-4057qib7 2065 8 ( ( -LRB- cord-005453-4057qib7 2065 9 26 26 CD cord-005453-4057qib7 2065 10 % % NN cord-005453-4057qib7 2065 11 ) ) -RRB- cord-005453-4057qib7 2065 12 , , , cord-005453-4057qib7 2065 13 a a DT cord-005453-4057qib7 2065 14 matched match VBN cord-005453-4057qib7 2065 15 unrelated unrelated JJ cord-005453-4057qib7 2065 16 ( ( -LRB- cord-005453-4057qib7 2065 17 65 65 CD cord-005453-4057qib7 2065 18 % % NN cord-005453-4057qib7 2065 19 ) ) -RRB- cord-005453-4057qib7 2065 20 or or CC cord-005453-4057qib7 2065 21 mismatched mismatch VBN cord-005453-4057qib7 2065 22 ( ( -LRB- cord-005453-4057qib7 2065 23 one one CD cord-005453-4057qib7 2065 24 allele allele NN cord-005453-4057qib7 2065 25 or or CC cord-005453-4057qib7 2065 26 one one CD cord-005453-4057qib7 2065 27 antigen antigen NN cord-005453-4057qib7 2065 28 mismatched mismatch VBN cord-005453-4057qib7 2065 29 ) ) -RRB- cord-005453-4057qib7 2065 30 unrelated unrelated JJ cord-005453-4057qib7 2065 31 , , , cord-005453-4057qib7 2065 32 9 9 CD cord-005453-4057qib7 2065 33 % % NN cord-005453-4057qib7 2065 34 . . . cord-005453-4057qib7 2066 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 2066 2 chimerism chimerism NN cord-005453-4057qib7 2066 3 was be VBD cord-005453-4057qib7 2066 4 molecularly molecularly RB cord-005453-4057qib7 2066 5 evaluated evaluate VBN cord-005453-4057qib7 2066 6 by by IN cord-005453-4057qib7 2066 7 Variable Variable NNP cord-005453-4057qib7 2066 8 Number Number NNP cord-005453-4057qib7 2066 9 of of IN cord-005453-4057qib7 2066 10 Tandem Tandem NNP cord-005453-4057qib7 2066 11 Repeats repeat VBZ cord-005453-4057qib7 2066 12 ( ( -LRB- cord-005453-4057qib7 2066 13 VNTR VNTR NNP cord-005453-4057qib7 2066 14 ) ) -RRB- cord-005453-4057qib7 2066 15 on on IN cord-005453-4057qib7 2066 16 bone bone NN cord-005453-4057qib7 2066 17 marrow marrow NN cord-005453-4057qib7 2066 18 ( ( -LRB- cord-005453-4057qib7 2066 19 BM BM NNP cord-005453-4057qib7 2066 20 ) ) -RRB- cord-005453-4057qib7 2066 21 mononuclear mononuclear NN cord-005453-4057qib7 2066 22 cells cell NNS cord-005453-4057qib7 2066 23 or or CC cord-005453-4057qib7 2066 24 peripheral peripheral JJ cord-005453-4057qib7 2066 25 blood blood NN cord-005453-4057qib7 2066 26 ( ( -LRB- cord-005453-4057qib7 2066 27 PB PB NNP cord-005453-4057qib7 2066 28 ) ) -RRB- cord-005453-4057qib7 2066 29 T t NN cord-005453-4057qib7 2066 30 lymphocytes lymphocyte NNS cord-005453-4057qib7 2066 31 , , , cord-005453-4057qib7 2066 32 purified purify VBN cord-005453-4057qib7 2066 33 by by IN cord-005453-4057qib7 2066 34 immunomagnetic immunomagnetic JJ cord-005453-4057qib7 2066 35 positive positive JJ cord-005453-4057qib7 2066 36 selection selection NN cord-005453-4057qib7 2066 37 ( ( -LRB- cord-005453-4057qib7 2066 38 Miltenyi Miltenyi NNP cord-005453-4057qib7 2066 39 , , , cord-005453-4057qib7 2066 40 Biotec Biotec NNP cord-005453-4057qib7 2066 41 ) ) -RRB- cord-005453-4057qib7 2066 42 . . . cord-005453-4057qib7 2067 1 The the DT cord-005453-4057qib7 2067 2 analysis analysis NN cord-005453-4057qib7 2067 3 was be VBD cord-005453-4057qib7 2067 4 performed perform VBN cord-005453-4057qib7 2067 5 at at IN cord-005453-4057qib7 2067 6 day day NN cord-005453-4057qib7 2067 7 30 30 CD cord-005453-4057qib7 2067 8 , , , cord-005453-4057qib7 2067 9 60 60 CD cord-005453-4057qib7 2067 10 , , , cord-005453-4057qib7 2067 11 90 90 CD cord-005453-4057qib7 2067 12 , , , cord-005453-4057qib7 2067 13 180 180 CD cord-005453-4057qib7 2067 14 and and CC cord-005453-4057qib7 2067 15 360 360 CD cord-005453-4057qib7 2067 16 after after IN cord-005453-4057qib7 2067 17 transplantation transplantation NN cord-005453-4057qib7 2067 18 Results result NNS cord-005453-4057qib7 2067 19 : : : cord-005453-4057qib7 2068 1 After after IN cord-005453-4057qib7 2068 2 30 30 CD cord-005453-4057qib7 2068 3 , , , cord-005453-4057qib7 2068 4 60 60 CD cord-005453-4057qib7 2068 5 and and CC cord-005453-4057qib7 2068 6 90 90 CD cord-005453-4057qib7 2068 7 days day NNS cord-005453-4057qib7 2068 8 from from IN cord-005453-4057qib7 2068 9 transplantation transplantation NN cord-005453-4057qib7 2068 10 , , , cord-005453-4057qib7 2068 11 the the DT cord-005453-4057qib7 2068 12 proportion proportion NN cord-005453-4057qib7 2068 13 of of IN cord-005453-4057qib7 2068 14 patients patient NNS cord-005453-4057qib7 2068 15 with with IN cord-005453-4057qib7 2068 16 a a DT cord-005453-4057qib7 2068 17 full full JJ cord-005453-4057qib7 2068 18 BM bm NN cord-005453-4057qib7 2068 19 chimerism chimerism NN cord-005453-4057qib7 2068 20 was be VBD cord-005453-4057qib7 2068 21 94 94 CD cord-005453-4057qib7 2068 22 % % NN cord-005453-4057qib7 2068 23 , , , cord-005453-4057qib7 2068 24 87 87 CD cord-005453-4057qib7 2068 25 % % NN cord-005453-4057qib7 2068 26 and and CC cord-005453-4057qib7 2068 27 83 83 CD cord-005453-4057qib7 2068 28 % % NN cord-005453-4057qib7 2068 29 , , , cord-005453-4057qib7 2068 30 respectively respectively RB cord-005453-4057qib7 2068 31 . . . cord-005453-4057qib7 2069 1 At at IN cord-005453-4057qib7 2069 2 the the DT cord-005453-4057qib7 2069 3 same same JJ cord-005453-4057qib7 2069 4 time time NN cord-005453-4057qib7 2069 5 points point NNS cord-005453-4057qib7 2069 6 , , , cord-005453-4057qib7 2069 7 the the DT cord-005453-4057qib7 2069 8 PB PB NNP cord-005453-4057qib7 2069 9 T T NNP cord-005453-4057qib7 2069 10 cell cell NN cord-005453-4057qib7 2069 11 chimerism chimerism NN cord-005453-4057qib7 2069 12 was be VBD cord-005453-4057qib7 2069 13 47 47 CD cord-005453-4057qib7 2069 14 % % NN cord-005453-4057qib7 2069 15 , , , cord-005453-4057qib7 2069 16 65 65 CD cord-005453-4057qib7 2069 17 % % NN cord-005453-4057qib7 2069 18 and and CC cord-005453-4057qib7 2069 19 69 69 CD cord-005453-4057qib7 2069 20 % % NN cord-005453-4057qib7 2069 21 . . . cord-005453-4057qib7 2070 1 Before before IN cord-005453-4057qib7 2070 2 day day NN cord-005453-4057qib7 2070 3 100 100 CD cord-005453-4057qib7 2070 4 , , , cord-005453-4057qib7 2070 5 10 10 CD cord-005453-4057qib7 2070 6 patients patient NNS cord-005453-4057qib7 2070 7 required require VBD cord-005453-4057qib7 2070 8 the the DT cord-005453-4057qib7 2070 9 infusion infusion NN cord-005453-4057qib7 2070 10 of of IN cord-005453-4057qib7 2070 11 DLI DLI NNP cord-005453-4057qib7 2070 12 to to TO cord-005453-4057qib7 2070 13 treat treat VB cord-005453-4057qib7 2070 14 a a DT cord-005453-4057qib7 2070 15 pending pende VBG cord-005453-4057qib7 2070 16 or or CC cord-005453-4057qib7 2070 17 overt overt JJ cord-005453-4057qib7 2070 18 hematologic hematologic JJ cord-005453-4057qib7 2070 19 relapse relapse NN cord-005453-4057qib7 2070 20 and and CC cord-005453-4057qib7 2070 21 12 12 CD cord-005453-4057qib7 2070 22 patients patient NNS cord-005453-4057qib7 2070 23 to to TO cord-005453-4057qib7 2070 24 convert convert VB cord-005453-4057qib7 2070 25 the the DT cord-005453-4057qib7 2070 26 lymphoid lymphoid JJ cord-005453-4057qib7 2070 27 chimerism chimerism NN cord-005453-4057qib7 2070 28 from from IN cord-005453-4057qib7 2070 29 mixed mixed JJ cord-005453-4057qib7 2070 30 ( ( -LRB- cord-005453-4057qib7 2070 31 median median NN cord-005453-4057qib7 2070 32 44 44 CD cord-005453-4057qib7 2070 33 % % NN cord-005453-4057qib7 2070 34 , , , cord-005453-4057qib7 2070 35 range range VBP cord-005453-4057qib7 2070 36 0 0 CD cord-005453-4057qib7 2070 37 - - HYPH cord-005453-4057qib7 2070 38 76 76 CD cord-005453-4057qib7 2070 39 ) ) -RRB- cord-005453-4057qib7 2070 40 , , , cord-005453-4057qib7 2070 41 to to TO cord-005453-4057qib7 2070 42 complete complete VB cord-005453-4057qib7 2070 43 ( ( -LRB- cord-005453-4057qib7 2070 44 successfully successfully RB cord-005453-4057qib7 2070 45 in in IN cord-005453-4057qib7 2070 46 7 7 CD cord-005453-4057qib7 2070 47 cases case NNS cord-005453-4057qib7 2070 48 ) ) -RRB- cord-005453-4057qib7 2070 49 . . . cord-005453-4057qib7 2071 1 After after IN cord-005453-4057qib7 2071 2 day day NN cord-005453-4057qib7 2071 3 100 100 CD cord-005453-4057qib7 2071 4 , , , cord-005453-4057qib7 2071 5 13 13 CD cord-005453-4057qib7 2071 6 additional additional JJ cord-005453-4057qib7 2071 7 patients patient NNS cord-005453-4057qib7 2071 8 required require VBD cord-005453-4057qib7 2071 9 DLI DLI NNP cord-005453-4057qib7 2071 10 to to TO cord-005453-4057qib7 2071 11 treat treat VB cord-005453-4057qib7 2071 12 disease disease NN cord-005453-4057qib7 2071 13 relapse relapse NN cord-005453-4057qib7 2071 14 or or CC cord-005453-4057qib7 2071 15 progression progression NN cord-005453-4057qib7 2071 16 and and CC cord-005453-4057qib7 2071 17 8 8 CD cord-005453-4057qib7 2071 18 patients patient NNS cord-005453-4057qib7 2071 19 to to TO cord-005453-4057qib7 2071 20 improve improve VB cord-005453-4057qib7 2071 21 the the DT cord-005453-4057qib7 2071 22 chimeric chimeric JJ cord-005453-4057qib7 2071 23 status status NN cord-005453-4057qib7 2071 24 or or CC cord-005453-4057qib7 2071 25 the the DT cord-005453-4057qib7 2071 26 immune immune JJ cord-005453-4057qib7 2071 27 reconstitution reconstitution NN cord-005453-4057qib7 2071 28 . . . cord-005453-4057qib7 2072 1 At at IN cord-005453-4057qib7 2072 2 5 5 CD cord-005453-4057qib7 2072 3 years year NNS cord-005453-4057qib7 2072 4 , , , cord-005453-4057qib7 2072 5 the the DT cord-005453-4057qib7 2072 6 Overall Overall NNP cord-005453-4057qib7 2072 7 Survival Survival NNP cord-005453-4057qib7 2072 8 is be VBZ cord-005453-4057qib7 2072 9 64 64 CD cord-005453-4057qib7 2072 10 % % NN cord-005453-4057qib7 2072 11 , , , cord-005453-4057qib7 2072 12 with with IN cord-005453-4057qib7 2072 13 a a DT cord-005453-4057qib7 2072 14 relapse relapse NN cord-005453-4057qib7 2072 15 and and CC cord-005453-4057qib7 2072 16 non non JJ cord-005453-4057qib7 2072 17 - - JJ cord-005453-4057qib7 2072 18 relapse relapse JJ cord-005453-4057qib7 2072 19 mortality mortality NN cord-005453-4057qib7 2072 20 of of IN cord-005453-4057qib7 2072 21 21 21 CD cord-005453-4057qib7 2072 22 % % NN cord-005453-4057qib7 2072 23 and and CC cord-005453-4057qib7 2072 24 11 11 CD cord-005453-4057qib7 2072 25 % % NN cord-005453-4057qib7 2072 26 , , , cord-005453-4057qib7 2072 27 respectively respectively RB cord-005453-4057qib7 2072 28 ( ( -LRB- cord-005453-4057qib7 2072 29 Figure figure NN cord-005453-4057qib7 2072 30 1 1 CD cord-005453-4057qib7 2072 31 ) ) -RRB- cord-005453-4057qib7 2072 32 . . . cord-005453-4057qib7 2073 1 By by IN cord-005453-4057qib7 2073 2 uni uni NNP cord-005453-4057qib7 2073 3 and and CC cord-005453-4057qib7 2073 4 multivariable multivariable JJ cord-005453-4057qib7 2073 5 analysis analysis NN cord-005453-4057qib7 2073 6 , , , cord-005453-4057qib7 2073 7 AML AML NNP cord-005453-4057qib7 2073 8 diagnosis diagnosis NN cord-005453-4057qib7 2073 9 and and CC cord-005453-4057qib7 2073 10 a a DT cord-005453-4057qib7 2073 11 mixed mixed JJ cord-005453-4057qib7 2073 12 BM bm NN cord-005453-4057qib7 2073 13 chimerism chimerism NN cord-005453-4057qib7 2073 14 before before IN cord-005453-4057qib7 2073 15 day day NN cord-005453-4057qib7 2073 16 100 100 CD cord-005453-4057qib7 2073 17 were be VBD cord-005453-4057qib7 2073 18 associated associate VBN cord-005453-4057qib7 2073 19 with with IN cord-005453-4057qib7 2073 20 Relapse Relapse NNP cord-005453-4057qib7 2073 21 and and CC cord-005453-4057qib7 2073 22 Overall Overall NNP cord-005453-4057qib7 2073 23 Survival Survival NNP cord-005453-4057qib7 2073 24 while while IN cord-005453-4057qib7 2073 25 age age NN cord-005453-4057qib7 2073 26 > > XX cord-005453-4057qib7 2073 27 50 50 CD cord-005453-4057qib7 2073 28 was be VBD cord-005453-4057qib7 2073 29 the the DT cord-005453-4057qib7 2073 30 only only JJ cord-005453-4057qib7 2073 31 factor factor NN cord-005453-4057qib7 2073 32 significantly significantly RB cord-005453-4057qib7 2073 33 associated associate VBN cord-005453-4057qib7 2073 34 with with IN cord-005453-4057qib7 2073 35 NRM NRM NNP cord-005453-4057qib7 2073 36 . . . cord-005453-4057qib7 2074 1 A a DT cord-005453-4057qib7 2074 2 mixed mixed JJ cord-005453-4057qib7 2074 3 PB PB NNP cord-005453-4057qib7 2074 4 T T NNP cord-005453-4057qib7 2074 5 - - HYPH cord-005453-4057qib7 2074 6 lymphoid lymphoid JJ cord-005453-4057qib7 2074 7 chimerism chimerism NN cord-005453-4057qib7 2074 8 before before IN cord-005453-4057qib7 2074 9 day day NN cord-005453-4057qib7 2074 10 100 100 CD cord-005453-4057qib7 2074 11 does do VBZ cord-005453-4057qib7 2074 12 not not RB cord-005453-4057qib7 2074 13 adversely adversely RB cord-005453-4057qib7 2074 14 impact impact VB cord-005453-4057qib7 2074 15 on on IN cord-005453-4057qib7 2074 16 non non JJ cord-005453-4057qib7 2074 17 - - JJ cord-005453-4057qib7 2074 18 relapse relapse JJ cord-005453-4057qib7 2074 19 mortality mortality NN cord-005453-4057qib7 2074 20 , , , cord-005453-4057qib7 2074 21 cumulative cumulative JJ cord-005453-4057qib7 2074 22 incidence incidence NN cord-005453-4057qib7 2074 23 of of IN cord-005453-4057qib7 2074 24 relapse relapse NN cord-005453-4057qib7 2074 25 , , , cord-005453-4057qib7 2074 26 leukemia leukemia NN cord-005453-4057qib7 2074 27 - - HYPH cord-005453-4057qib7 2074 28 free free JJ cord-005453-4057qib7 2074 29 and and CC cord-005453-4057qib7 2074 30 overall overall JJ cord-005453-4057qib7 2074 31 survival survival NN cord-005453-4057qib7 2074 32 . . . cord-005453-4057qib7 2075 1 Conclusions conclusion NNS cord-005453-4057qib7 2075 2 : : : cord-005453-4057qib7 2076 1 After after IN cord-005453-4057qib7 2076 2 FB4 FB4 NNP cord-005453-4057qib7 2076 3 and and CC cord-005453-4057qib7 2076 4 ATG ATG NNP cord-005453-4057qib7 2076 5 , , , cord-005453-4057qib7 2076 6 a a DT cord-005453-4057qib7 2076 7 progressive progressive JJ cord-005453-4057qib7 2076 8 increase increase NN cord-005453-4057qib7 2076 9 of of IN cord-005453-4057qib7 2076 10 PB PB NNP cord-005453-4057qib7 2076 11 lymphoid lymphoid JJ cord-005453-4057qib7 2076 12 donor donor NN cord-005453-4057qib7 2076 13 chimerism chimerism NN cord-005453-4057qib7 2076 14 develops develop VBZ cord-005453-4057qib7 2076 15 gradually gradually RB cord-005453-4057qib7 2076 16 after after IN cord-005453-4057qib7 2076 17 transplantation transplantation NN cord-005453-4057qib7 2076 18 , , , cord-005453-4057qib7 2076 19 in in IN cord-005453-4057qib7 2076 20 most most JJS cord-005453-4057qib7 2076 21 of of IN cord-005453-4057qib7 2076 22 cases case NNS cord-005453-4057qib7 2076 23 without without IN cord-005453-4057qib7 2076 24 the the DT cord-005453-4057qib7 2076 25 need need NN cord-005453-4057qib7 2076 26 of of IN cord-005453-4057qib7 2076 27 DLI DLI NNP cord-005453-4057qib7 2076 28 . . . cord-005453-4057qib7 2077 1 Early early JJ cord-005453-4057qib7 2077 2 mixed mixed JJ cord-005453-4057qib7 2077 3 lymphoid lymphoid JJ cord-005453-4057qib7 2077 4 chimerism chimerism NN cord-005453-4057qib7 2077 5 does do VBZ cord-005453-4057qib7 2077 6 not not RB cord-005453-4057qib7 2077 7 compromise compromise VB cord-005453-4057qib7 2077 8 the the DT cord-005453-4057qib7 2077 9 main main JJ cord-005453-4057qib7 2077 10 long long JJ cord-005453-4057qib7 2077 11 - - HYPH cord-005453-4057qib7 2077 12 term term NN cord-005453-4057qib7 2077 13 clinical clinical JJ cord-005453-4057qib7 2077 14 outcomes outcome NNS cord-005453-4057qib7 2077 15 and and CC cord-005453-4057qib7 2077 16 may may MD cord-005453-4057qib7 2077 17 at at IN cord-005453-4057qib7 2077 18 least least RBS cord-005453-4057qib7 2077 19 partially partially RB cord-005453-4057qib7 2077 20 explain explain VB cord-005453-4057qib7 2077 21 the the DT cord-005453-4057qib7 2077 22 low low JJ cord-005453-4057qib7 2077 23 non non JJ cord-005453-4057qib7 2077 24 - - JJ cord-005453-4057qib7 2077 25 relapse relapse JJ cord-005453-4057qib7 2077 26 mortality mortality NN cord-005453-4057qib7 2077 27 . . . cord-005453-4057qib7 2078 1 An an DT cord-005453-4057qib7 2078 2 incomplete incomplete JJ cord-005453-4057qib7 2078 3 BM bm NN cord-005453-4057qib7 2078 4 chimerism chimerism NN cord-005453-4057qib7 2078 5 within within IN cord-005453-4057qib7 2078 6 the the DT cord-005453-4057qib7 2078 7 first first JJ cord-005453-4057qib7 2078 8 3 3 CD cord-005453-4057qib7 2078 9 months month NNS cord-005453-4057qib7 2078 10 strongly strongly RB cord-005453-4057qib7 2078 11 correlates correlate VBZ cord-005453-4057qib7 2078 12 with with IN cord-005453-4057qib7 2078 13 early early JJ cord-005453-4057qib7 2078 14 disease disease NN cord-005453-4057qib7 2078 15 progression progression NN cord-005453-4057qib7 2078 16 or or CC cord-005453-4057qib7 2078 17 relapse relapse NN cord-005453-4057qib7 2078 18 . . . cord-005453-4057qib7 2079 1 Background background NN cord-005453-4057qib7 2079 2 : : : cord-005453-4057qib7 2080 1 Busulfan Busulfan NNP cord-005453-4057qib7 2080 2 ( ( -LRB- cord-005453-4057qib7 2080 3 Bu Bu NNP cord-005453-4057qib7 2080 4 ) ) -RRB- cord-005453-4057qib7 2080 5 is be VBZ cord-005453-4057qib7 2080 6 widely widely RB cord-005453-4057qib7 2080 7 used use VBN cord-005453-4057qib7 2080 8 as as IN cord-005453-4057qib7 2080 9 a a DT cord-005453-4057qib7 2080 10 component component NN cord-005453-4057qib7 2080 11 of of IN cord-005453-4057qib7 2080 12 myeloablative myeloablative JJ cord-005453-4057qib7 2080 13 conditioning conditioning NN cord-005453-4057qib7 2080 14 regimen regimen NN cord-005453-4057qib7 2080 15 before before IN cord-005453-4057qib7 2080 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 2080 17 stem stem NN cord-005453-4057qib7 2080 18 cell cell NN cord-005453-4057qib7 2080 19 transplantation transplantation NN cord-005453-4057qib7 2080 20 ( ( -LRB- cord-005453-4057qib7 2080 21 HSCT HSCT NNP cord-005453-4057qib7 2080 22 ) ) -RRB- cord-005453-4057qib7 2080 23 in in IN cord-005453-4057qib7 2080 24 children child NNS cord-005453-4057qib7 2080 25 . . . cord-005453-4057qib7 2081 1 Bu Bu NNP cord-005453-4057qib7 2081 2 has have VBZ cord-005453-4057qib7 2081 3 a a DT cord-005453-4057qib7 2081 4 narrow narrow JJ cord-005453-4057qib7 2081 5 cumulative cumulative JJ cord-005453-4057qib7 2081 6 exposure exposure NN cord-005453-4057qib7 2081 7 window window NN cord-005453-4057qib7 2081 8 . . . cord-005453-4057qib7 2082 1 The the DT cord-005453-4057qib7 2082 2 relation relation NN cord-005453-4057qib7 2082 3 of of IN cord-005453-4057qib7 2082 4 Bu Bu NNP cord-005453-4057qib7 2082 5 exposure exposure NN cord-005453-4057qib7 2082 6 with with IN cord-005453-4057qib7 2082 7 toxicity toxicity NN cord-005453-4057qib7 2082 8 is be VBZ cord-005453-4057qib7 2082 9 well well RB cord-005453-4057qib7 2082 10 established establish VBN cord-005453-4057qib7 2082 11 , , , cord-005453-4057qib7 2082 12 but but CC cord-005453-4057qib7 2082 13 the the DT cord-005453-4057qib7 2082 14 link link NN cord-005453-4057qib7 2082 15 between between IN cord-005453-4057qib7 2082 16 the the DT cord-005453-4057qib7 2082 17 exposure exposure NN cord-005453-4057qib7 2082 18 and and CC cord-005453-4057qib7 2082 19 EFS efs NN cord-005453-4057qib7 2082 20 is be VBZ cord-005453-4057qib7 2082 21 not not RB cord-005453-4057qib7 2082 22 clear clear JJ cord-005453-4057qib7 2082 23 due due IN cord-005453-4057qib7 2082 24 to to IN cord-005453-4057qib7 2082 25 conflicting conflicting JJ cord-005453-4057qib7 2082 26 reports report NNS cord-005453-4057qib7 2082 27 especially especially RB cord-005453-4057qib7 2082 28 in in IN cord-005453-4057qib7 2082 29 pediatric pediatric JJ cord-005453-4057qib7 2082 30 patients patient NNS cord-005453-4057qib7 2082 31 . . . cord-005453-4057qib7 2083 1 Obtaining obtain VBG cord-005453-4057qib7 2083 2 the the DT cord-005453-4057qib7 2083 3 ratio ratio NN cord-005453-4057qib7 2083 4 of of IN cord-005453-4057qib7 2083 5 Bu Bu NNP cord-005453-4057qib7 2083 6 to to IN cord-005453-4057qib7 2083 7 its -PRON- PRP$ cord-005453-4057qib7 2083 8 metabolite metabolite JJ cord-005453-4057qib7 2083 9 i.e. i.e. FW cord-005453-4057qib7 2083 10 metabolic metabolic JJ cord-005453-4057qib7 2083 11 ratio ratio NN cord-005453-4057qib7 2083 12 ( ( -LRB- cord-005453-4057qib7 2083 13 MR MR NNP cord-005453-4057qib7 2083 14 ) ) -RRB- cord-005453-4057qib7 2083 15 may may MD cord-005453-4057qib7 2083 16 serve serve VB cord-005453-4057qib7 2083 17 as as IN cord-005453-4057qib7 2083 18 an an DT cord-005453-4057qib7 2083 19 indicator indicator NN cord-005453-4057qib7 2083 20 of of IN cord-005453-4057qib7 2083 21 Bu Bu NNP cord-005453-4057qib7 2083 22 GSH GSH NNP cord-005453-4057qib7 2083 23 conjugating conjugate VBG cord-005453-4057qib7 2083 24 capacity capacity NN cord-005453-4057qib7 2083 25 of of IN cord-005453-4057qib7 2083 26 an an DT cord-005453-4057qib7 2083 27 individual individual NN cord-005453-4057qib7 2083 28 , , , cord-005453-4057qib7 2083 29 thus thus RB cord-005453-4057qib7 2083 30 cumulative cumulative JJ cord-005453-4057qib7 2083 31 exposure exposure NN cord-005453-4057qib7 2083 32 of of IN cord-005453-4057qib7 2083 33 Bu Bu NNP cord-005453-4057qib7 2083 34 for for IN cord-005453-4057qib7 2083 35 a a DT cord-005453-4057qib7 2083 36 particular particular JJ cord-005453-4057qib7 2083 37 day day NN cord-005453-4057qib7 2083 38 that that WDT cord-005453-4057qib7 2083 39 could could MD cord-005453-4057qib7 2083 40 be be VB cord-005453-4057qib7 2083 41 used use VBN cord-005453-4057qib7 2083 42 along along IN cord-005453-4057qib7 2083 43 with with IN cord-005453-4057qib7 2083 44 AUC AUC NNP cord-005453-4057qib7 2083 45 as as IN cord-005453-4057qib7 2083 46 a a DT cord-005453-4057qib7 2083 47 marker marker NN cord-005453-4057qib7 2083 48 to to TO cord-005453-4057qib7 2083 49 predict predict VB cord-005453-4057qib7 2083 50 EFS EFS NNP cord-005453-4057qib7 2083 51 . . . cord-005453-4057qib7 2084 1 The the DT cord-005453-4057qib7 2084 2 present present JJ cord-005453-4057qib7 2084 3 investigation investigation NN cord-005453-4057qib7 2084 4 is be VBZ cord-005453-4057qib7 2084 5 aimed aim VBN cord-005453-4057qib7 2084 6 at at IN cord-005453-4057qib7 2084 7 evaluating evaluate VBG cord-005453-4057qib7 2084 8 the the DT cord-005453-4057qib7 2084 9 utility utility NN cord-005453-4057qib7 2084 10 of of IN cord-005453-4057qib7 2084 11 Bu Bu NNP cord-005453-4057qib7 2084 12 MR MR NNP cord-005453-4057qib7 2084 13 to to TO cord-005453-4057qib7 2084 14 predict predict VB cord-005453-4057qib7 2084 15 EFS efs NN cord-005453-4057qib7 2084 16 in in IN cord-005453-4057qib7 2084 17 children child NNS cord-005453-4057qib7 2084 18 undergoing undergo VBG cord-005453-4057qib7 2084 19 allogeneic allogeneic IN cord-005453-4057qib7 2084 20 HSCT HSCT NNP cord-005453-4057qib7 2084 21 . . . cord-005453-4057qib7 2085 1 Methods method NNS cord-005453-4057qib7 2085 2 : : : cord-005453-4057qib7 2086 1 Two two CD cord-005453-4057qib7 2086 2 different different JJ cord-005453-4057qib7 2086 3 cohorts cohort NNS cord-005453-4057qib7 2086 4 with with IN cord-005453-4057qib7 2086 5 children child NNS cord-005453-4057qib7 2086 6 receiving receive VBG cord-005453-4057qib7 2086 7 Bu Bu NNP cord-005453-4057qib7 2086 8 in in IN cord-005453-4057qib7 2086 9 four four CD cord-005453-4057qib7 2086 10 times time NNS cord-005453-4057qib7 2086 11 daily daily JJ cord-005453-4057qib7 2086 12 ( ( -LRB- cord-005453-4057qib7 2086 13 QID QID NNP cord-005453-4057qib7 2086 14 , , , cord-005453-4057qib7 2086 15 n=44 n=44 NNP cord-005453-4057qib7 2086 16 ) ) -RRB- cord-005453-4057qib7 2086 17 and and CC cord-005453-4057qib7 2086 18 once once IN cord-005453-4057qib7 2086 19 daily daily JJ cord-005453-4057qib7 2086 20 doses dose NNS cord-005453-4057qib7 2086 21 ( ( -LRB- cord-005453-4057qib7 2086 22 QD QD NNP cord-005453-4057qib7 2086 23 , , , cord-005453-4057qib7 2086 24 n=13 n=13 NNP cord-005453-4057qib7 2086 25 ) ) -RRB- cord-005453-4057qib7 2086 26 at at IN cord-005453-4057qib7 2086 27 St. St. NNP cord-005453-4057qib7 2086 28 Justine Justine NNP cord-005453-4057qib7 2086 29 's 's POS cord-005453-4057qib7 2086 30 Hospital Hospital NNP cord-005453-4057qib7 2086 31 , , , cord-005453-4057qib7 2086 32 Montreal Montreal NNP cord-005453-4057qib7 2086 33 were be VBD cord-005453-4057qib7 2086 34 studied study VBN cord-005453-4057qib7 2086 35 . . . cord-005453-4057qib7 2087 1 Bu Bu NNP cord-005453-4057qib7 2087 2 and and CC cord-005453-4057qib7 2087 3 Su Su NNP cord-005453-4057qib7 2087 4 levels level NNS cord-005453-4057qib7 2087 5 were be VBD cord-005453-4057qib7 2087 6 measured measure VBN cord-005453-4057qib7 2087 7 on on IN cord-005453-4057qib7 2087 8 day day NN cord-005453-4057qib7 2087 9 3 3 CD cord-005453-4057qib7 2087 10 of of IN cord-005453-4057qib7 2087 11 the the DT cord-005453-4057qib7 2087 12 conditioning conditioning NN cord-005453-4057qib7 2087 13 regimen regimen NN cord-005453-4057qib7 2087 14 at at IN cord-005453-4057qib7 2087 15 the the DT cord-005453-4057qib7 2087 16 end end NN cord-005453-4057qib7 2087 17 of of IN cord-005453-4057qib7 2087 18 infusion infusion NN cord-005453-4057qib7 2087 19 ( ( -LRB- cord-005453-4057qib7 2087 20 dose dose NN cord-005453-4057qib7 2087 21 9 9 CD cord-005453-4057qib7 2087 22 in in IN cord-005453-4057qib7 2087 23 QID QID NNP cord-005453-4057qib7 2087 24 or or CC cord-005453-4057qib7 2087 25 dose dose NN cord-005453-4057qib7 2087 26 3 3 CD cord-005453-4057qib7 2087 27 in in IN cord-005453-4057qib7 2087 28 QD QD NNP cord-005453-4057qib7 2087 29 dosing dose VBG cord-005453-4057qib7 2087 30 ) ) -RRB- cord-005453-4057qib7 2087 31 . . . cord-005453-4057qib7 2088 1 EFS EFS NNP cord-005453-4057qib7 2088 2 was be VBD cord-005453-4057qib7 2088 3 defined define VBN cord-005453-4057qib7 2088 4 from from IN cord-005453-4057qib7 2088 5 the the DT cord-005453-4057qib7 2088 6 time time NN cord-005453-4057qib7 2088 7 of of IN cord-005453-4057qib7 2088 8 transplant transplant NN cord-005453-4057qib7 2088 9 until until IN cord-005453-4057qib7 2088 10 death death NN cord-005453-4057qib7 2088 11 , , , cord-005453-4057qib7 2088 12 relapse relapse NN cord-005453-4057qib7 2088 13 , , , cord-005453-4057qib7 2088 14 or or CC cord-005453-4057qib7 2088 15 rejection rejection NN cord-005453-4057qib7 2088 16 , , , cord-005453-4057qib7 2088 17 whichever whichever WDT cord-005453-4057qib7 2088 18 occurred occur VBD cord-005453-4057qib7 2088 19 first first RB cord-005453-4057qib7 2088 20 . . . cord-005453-4057qib7 2089 1 A a DT cord-005453-4057qib7 2089 2 receiver receiver NN cord-005453-4057qib7 2089 3 - - HYPH cord-005453-4057qib7 2089 4 operator operator NN cord-005453-4057qib7 2089 5 characteristic characteristic JJ cord-005453-4057qib7 2089 6 curve curve NN cord-005453-4057qib7 2089 7 ( ( -LRB- cord-005453-4057qib7 2089 8 ROC ROC NNP cord-005453-4057qib7 2089 9 ) ) -RRB- cord-005453-4057qib7 2089 10 for for IN cord-005453-4057qib7 2089 11 Bu Bu NNP cord-005453-4057qib7 2089 12 MRs MRs NNP cord-005453-4057qib7 2089 13 measured measured NNP cord-005453-4057qib7 2089 14 was be VBD cord-005453-4057qib7 2089 15 plotted plot VBN cord-005453-4057qib7 2089 16 to to TO cord-005453-4057qib7 2089 17 show show VB cord-005453-4057qib7 2089 18 the the DT cord-005453-4057qib7 2089 19 trade trade NN cord-005453-4057qib7 2089 20 - - HYPH cord-005453-4057qib7 2089 21 off off NN cord-005453-4057qib7 2089 22 in in IN cord-005453-4057qib7 2089 23 sensitivity sensitivity NN cord-005453-4057qib7 2089 24 vs. vs. IN cord-005453-4057qib7 2089 25 1-specificity 1-specificity CD cord-005453-4057qib7 2089 26 rates rate NNS cord-005453-4057qib7 2089 27 for for IN cord-005453-4057qib7 2089 28 EFS efs NN cord-005453-4057qib7 2089 29 , , , cord-005453-4057qib7 2089 30 as as IN cord-005453-4057qib7 2089 31 the the DT cord-005453-4057qib7 2089 32 cut cut NN cord-005453-4057qib7 2089 33 - - HYPH cord-005453-4057qib7 2089 34 off off NN cord-005453-4057qib7 2089 35 of of IN cord-005453-4057qib7 2089 36 the the DT cord-005453-4057qib7 2089 37 test test NN cord-005453-4057qib7 2089 38 was be VBD cord-005453-4057qib7 2089 39 shifted shift VBN cord-005453-4057qib7 2089 40 from from IN cord-005453-4057qib7 2089 41 low low JJ cord-005453-4057qib7 2089 42 to to IN cord-005453-4057qib7 2089 43 high high JJ cord-005453-4057qib7 2089 44 . . . cord-005453-4057qib7 2090 1 Cutoff cutoff NN cord-005453-4057qib7 2090 2 values value NNS cord-005453-4057qib7 2090 3 were be VBD cord-005453-4057qib7 2090 4 defined define VBN cord-005453-4057qib7 2090 5 based base VBN cord-005453-4057qib7 2090 6 on on IN cord-005453-4057qib7 2090 7 the the DT cord-005453-4057qib7 2090 8 Youden´s Youden´s NNPS cord-005453-4057qib7 2090 9 J J NNP cord-005453-4057qib7 2090 10 statistic statistic NN cord-005453-4057qib7 2090 11 ( ( -LRB- cord-005453-4057qib7 2090 12 i.e. i.e. FW cord-005453-4057qib7 2090 13 sensitivity+specificty-1 sensitivity+specificty-1 NN cord-005453-4057qib7 2090 14 ) ) -RRB- cord-005453-4057qib7 2090 15 . . . cord-005453-4057qib7 2091 1 Results result NNS cord-005453-4057qib7 2091 2 : : : cord-005453-4057qib7 2092 1 Twenty twenty CD cord-005453-4057qib7 2092 2 - - HYPH cord-005453-4057qib7 2092 3 two two CD cord-005453-4057qib7 2092 4 males male NNS cord-005453-4057qib7 2092 5 and and CC cord-005453-4057qib7 2092 6 22 22 CD cord-005453-4057qib7 2092 7 females female NNS cord-005453-4057qib7 2092 8 aged age VBN cord-005453-4057qib7 2092 9 from from IN cord-005453-4057qib7 2092 10 0.1 0.1 CD cord-005453-4057qib7 2092 11 to to TO cord-005453-4057qib7 2092 12 19.9 19.9 CD cord-005453-4057qib7 2092 13 years year NNS cord-005453-4057qib7 2093 1 ( ( -LRB- cord-005453-4057qib7 2093 2 mean±SD mean±SD NNP cord-005453-4057qib7 2093 3 : : : cord-005453-4057qib7 2093 4 7.2 7.2 CD cord-005453-4057qib7 2093 5 ± ± NNP cord-005453-4057qib7 2093 6 5.7 5.7 CD cord-005453-4057qib7 2093 7 ) ) -RRB- cord-005453-4057qib7 2093 8 from from IN cord-005453-4057qib7 2093 9 Bu Bu NNP cord-005453-4057qib7 2093 10 QID QID NNP cord-005453-4057qib7 2093 11 cohort cohort NN cord-005453-4057qib7 2093 12 had have VBD cord-005453-4057qib7 2093 13 the the DT cord-005453-4057qib7 2093 14 mean mean JJ cord-005453-4057qib7 2093 15 MR MR NNP cord-005453-4057qib7 2093 16 of of IN cord-005453-4057qib7 2093 17 5.9 5.9 CD cord-005453-4057qib7 2093 18 ( ( -LRB- cord-005453-4057qib7 2093 19 SD sd NN cord-005453-4057qib7 2093 20 : : : cord-005453-4057qib7 2093 21 3.2 3.2 CD cord-005453-4057qib7 2093 22 ) ) -RRB- cord-005453-4057qib7 2093 23 . . . cord-005453-4057qib7 2094 1 A a DT cord-005453-4057qib7 2094 2 cut cut NN cord-005453-4057qib7 2094 3 off off RP cord-005453-4057qib7 2094 4 value value NN cord-005453-4057qib7 2094 5 of of IN cord-005453-4057qib7 2094 6 4.9 4.9 CD cord-005453-4057qib7 2094 7 in in IN cord-005453-4057qib7 2094 8 MR MR NNP cord-005453-4057qib7 2094 9 was be VBD cord-005453-4057qib7 2094 10 chosen choose VBN cord-005453-4057qib7 2094 11 in in IN cord-005453-4057qib7 2094 12 ROC ROC NNP cord-005453-4057qib7 2094 13 analysis analysis NN cord-005453-4057qib7 2094 14 in in IN cord-005453-4057qib7 2094 15 this this DT cord-005453-4057qib7 2094 16 cohort cohort NN cord-005453-4057qib7 2094 17 , , , cord-005453-4057qib7 2094 18 with with IN cord-005453-4057qib7 2094 19 better well JJR cord-005453-4057qib7 2094 20 sensitivity sensitivity NN cord-005453-4057qib7 2094 21 ( ( -LRB- cord-005453-4057qib7 2094 22 71 71 CD cord-005453-4057qib7 2094 23 % % NN cord-005453-4057qib7 2094 24 ) ) -RRB- cord-005453-4057qib7 2094 25 and and CC cord-005453-4057qib7 2094 26 specificity specificity NN cord-005453-4057qib7 2094 27 ( ( -LRB- cord-005453-4057qib7 2094 28 70 70 CD cord-005453-4057qib7 2094 29 % % NN cord-005453-4057qib7 2094 30 ) ) -RRB- cord-005453-4057qib7 2094 31 for for IN cord-005453-4057qib7 2094 32 EFS efs NN cord-005453-4057qib7 2094 33 prediction prediction NN cord-005453-4057qib7 2094 34 ( ( -LRB- cord-005453-4057qib7 2094 35 p=0.01 p=0.01 NNP cord-005453-4057qib7 2094 36 , , , cord-005453-4057qib7 2094 37 AUC= auc= CD cord-005453-4057qib7 2094 38 0.7 0.7 CD cord-005453-4057qib7 2094 39 ( ( -LRB- cord-005453-4057qib7 2094 40 95 95 CD cord-005453-4057qib7 2094 41 % % NN cord-005453-4057qib7 2094 42 CI= ci= CD cord-005453-4057qib7 2094 43 0.6 0.6 CD cord-005453-4057qib7 2094 44 - - SYM cord-005453-4057qib7 2094 45 0.8 0.8 CD cord-005453-4057qib7 2094 46 ) ) -RRB- cord-005453-4057qib7 2094 47 . . . cord-005453-4057qib7 2095 1 In in IN cord-005453-4057qib7 2095 2 QD QD NNP cord-005453-4057qib7 2095 3 cohort cohort NN cord-005453-4057qib7 2095 4 nine nine CD cord-005453-4057qib7 2095 5 females female NNS cord-005453-4057qib7 2095 6 , , , cord-005453-4057qib7 2095 7 and and CC cord-005453-4057qib7 2095 8 four four CD cord-005453-4057qib7 2095 9 males male NNS cord-005453-4057qib7 2095 10 aged age VBN cord-005453-4057qib7 2095 11 between between IN cord-005453-4057qib7 2095 12 0.4 0.4 CD cord-005453-4057qib7 2095 13 and and CC cord-005453-4057qib7 2095 14 15.8 15.8 CD cord-005453-4057qib7 2095 15 years year NNS cord-005453-4057qib7 2095 16 ( ( -LRB- cord-005453-4057qib7 2095 17 6.7±5.1 6.7±5.1 NNP cord-005453-4057qib7 2095 18 ) ) -RRB- cord-005453-4057qib7 2095 19 had have VBD cord-005453-4057qib7 2095 20 the the DT cord-005453-4057qib7 2095 21 mean mean JJ cord-005453-4057qib7 2095 22 MR MR NNP cord-005453-4057qib7 2095 23 of of IN cord-005453-4057qib7 2095 24 29.3 29.3 CD cord-005453-4057qib7 2095 25 ( ( -LRB- cord-005453-4057qib7 2095 26 SD sd NN cord-005453-4057qib7 2095 27 : : : cord-005453-4057qib7 2095 28 16.6 16.6 CD cord-005453-4057qib7 2095 29 ) ) -RRB- cord-005453-4057qib7 2095 30 . . . cord-005453-4057qib7 2096 1 In in IN cord-005453-4057qib7 2096 2 ROC ROC NNP cord-005453-4057qib7 2096 3 analysis analysis NN cord-005453-4057qib7 2096 4 , , , cord-005453-4057qib7 2096 5 a a DT cord-005453-4057qib7 2096 6 cut cut NN cord-005453-4057qib7 2096 7 off off RP cord-005453-4057qib7 2096 8 value value NN cord-005453-4057qib7 2096 9 of of IN cord-005453-4057qib7 2096 10 25.06 25.06 CD cord-005453-4057qib7 2096 11 was be VBD cord-005453-4057qib7 2096 12 chosen choose VBN cord-005453-4057qib7 2096 13 with with IN cord-005453-4057qib7 2096 14 better well JJR cord-005453-4057qib7 2096 15 sensitivity sensitivity NN cord-005453-4057qib7 2096 16 ( ( -LRB- cord-005453-4057qib7 2096 17 100 100 CD cord-005453-4057qib7 2096 18 % % NN cord-005453-4057qib7 2096 19 ) ) -RRB- cord-005453-4057qib7 2096 20 and and CC cord-005453-4057qib7 2096 21 specificity specificity NN cord-005453-4057qib7 2096 22 ( ( -LRB- cord-005453-4057qib7 2096 23 100 100 CD cord-005453-4057qib7 2096 24 % % NN cord-005453-4057qib7 2096 25 ) ) -RRB- cord-005453-4057qib7 2096 26 for for IN cord-005453-4057qib7 2096 27 EFS efs NN cord-005453-4057qib7 2096 28 prediction prediction NN cord-005453-4057qib7 2096 29 ( ( -LRB- cord-005453-4057qib7 2096 30 p=0.003 p=0.003 NNP cord-005453-4057qib7 2096 31 ; ; : cord-005453-4057qib7 2096 32 AUC=1.0 AUC=1.0 NNP cord-005453-4057qib7 2096 33 ) ) -RRB- cord-005453-4057qib7 2096 34 . . . cord-005453-4057qib7 2097 1 Conclusions conclusion NNS cord-005453-4057qib7 2097 2 Background Background NNP cord-005453-4057qib7 2097 3 : : : cord-005453-4057qib7 2098 1 Treosulfan Treosulfan NNP cord-005453-4057qib7 2098 2 is be VBZ cord-005453-4057qib7 2098 3 an an DT cord-005453-4057qib7 2098 4 alkylating alkylating JJ cord-005453-4057qib7 2098 5 agent agent NN cord-005453-4057qib7 2098 6 increasingly increasingly RB cord-005453-4057qib7 2098 7 used use VBN cord-005453-4057qib7 2098 8 prior prior RB cord-005453-4057qib7 2098 9 to to IN cord-005453-4057qib7 2098 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 2098 11 stem stem NN cord-005453-4057qib7 2098 12 cell cell NN cord-005453-4057qib7 2098 13 transplantation transplantation NN cord-005453-4057qib7 2098 14 ( ( -LRB- cord-005453-4057qib7 2098 15 HSCT HSCT NNP cord-005453-4057qib7 2098 16 ) ) -RRB- cord-005453-4057qib7 2098 17 . . . cord-005453-4057qib7 2099 1 The the DT cord-005453-4057qib7 2099 2 main main JJ cord-005453-4057qib7 2099 3 objective objective NN cord-005453-4057qib7 2099 4 of of IN cord-005453-4057qib7 2099 5 this this DT cord-005453-4057qib7 2099 6 study study NN cord-005453-4057qib7 2099 7 was be VBD cord-005453-4057qib7 2099 8 to to TO cord-005453-4057qib7 2099 9 develop develop VB cord-005453-4057qib7 2099 10 a a DT cord-005453-4057qib7 2099 11 population population NN cord-005453-4057qib7 2099 12 pharmacokinetic pharmacokinetic JJ cord-005453-4057qib7 2099 13 model model NN cord-005453-4057qib7 2099 14 of of IN cord-005453-4057qib7 2099 15 treosulfan treosulfan NNP cord-005453-4057qib7 2099 16 in in IN cord-005453-4057qib7 2099 17 pediatric pediatric JJ cord-005453-4057qib7 2099 18 HSCT HSCT NNP cord-005453-4057qib7 2099 19 recipients recipient NNS cord-005453-4057qib7 2099 20 and and CC cord-005453-4057qib7 2099 21 to to TO cord-005453-4057qib7 2099 22 explore explore VB cord-005453-4057qib7 2099 23 the the DT cord-005453-4057qib7 2099 24 effect effect NN cord-005453-4057qib7 2099 25 of of IN cord-005453-4057qib7 2099 26 different different JJ cord-005453-4057qib7 2099 27 covariates covariate NNS cord-005453-4057qib7 2099 28 on on IN cord-005453-4057qib7 2099 29 treosulfan treosulfan NNP cord-005453-4057qib7 2099 30 pharmacokinetics pharmacokinetics NNP cord-005453-4057qib7 2099 31 ( ( -LRB- cord-005453-4057qib7 2099 32 PK PK NNP cord-005453-4057qib7 2099 33 ) ) -RRB- cord-005453-4057qib7 2099 34 . . . cord-005453-4057qib7 2100 1 Also also RB cord-005453-4057qib7 2100 2 , , , cord-005453-4057qib7 2100 3 a a DT cord-005453-4057qib7 2100 4 limited limited JJ cord-005453-4057qib7 2100 5 sampling sampling NN cord-005453-4057qib7 2100 6 model model NN cord-005453-4057qib7 2100 7 ( ( -LRB- cord-005453-4057qib7 2100 8 LSM LSM NNP cord-005453-4057qib7 2100 9 ) ) -RRB- cord-005453-4057qib7 2100 10 was be VBD cord-005453-4057qib7 2100 11 developed develop VBN cord-005453-4057qib7 2100 12 . . . cord-005453-4057qib7 2101 1 Methods method NNS cord-005453-4057qib7 2101 2 : : : cord-005453-4057qib7 2101 3 In in IN cord-005453-4057qib7 2101 4 this this DT cord-005453-4057qib7 2101 5 multicentre multicentre NNP cord-005453-4057qib7 2101 6 study study NN cord-005453-4057qib7 2101 7 , , , cord-005453-4057qib7 2101 8 91 91 CD cord-005453-4057qib7 2101 9 patients patient NNS cord-005453-4057qib7 2101 10 , , , cord-005453-4057qib7 2101 11 receiving receive VBG cord-005453-4057qib7 2101 12 a a DT cord-005453-4057qib7 2101 13 dose dose NN cord-005453-4057qib7 2101 14 of of IN cord-005453-4057qib7 2101 15 10 10 CD cord-005453-4057qib7 2101 16 , , , cord-005453-4057qib7 2101 17 12 12 CD cord-005453-4057qib7 2101 18 or or CC cord-005453-4057qib7 2101 19 14 14 CD cord-005453-4057qib7 2101 20 g g NN cord-005453-4057qib7 2101 21 / / SYM cord-005453-4057qib7 2101 22 m m NN cord-005453-4057qib7 2101 23 2 2 CD cord-005453-4057qib7 2101 24 treosulfan treosulfan NNP cord-005453-4057qib7 2101 25 a a DT cord-005453-4057qib7 2101 26 day day NN cord-005453-4057qib7 2101 27 , , , cord-005453-4057qib7 2101 28 administered administer VBN cord-005453-4057qib7 2101 29 during during IN cord-005453-4057qib7 2101 30 3 3 CD cord-005453-4057qib7 2101 31 consecutive consecutive JJ cord-005453-4057qib7 2101 32 days day NNS cord-005453-4057qib7 2101 33 , , , cord-005453-4057qib7 2101 34 were be VBD cord-005453-4057qib7 2101 35 enrolled enrol VBN cord-005453-4057qib7 2101 36 . . . cord-005453-4057qib7 2102 1 A a DT cord-005453-4057qib7 2102 2 population population NN cord-005453-4057qib7 2102 3 pharmacokinetic pharmacokinetic JJ cord-005453-4057qib7 2102 4 model model NN cord-005453-4057qib7 2102 5 was be VBD cord-005453-4057qib7 2102 6 developed develop VBN cord-005453-4057qib7 2102 7 using use VBG cord-005453-4057qib7 2102 8 nonlinear nonlinear JJ cord-005453-4057qib7 2102 9 mixed mixed JJ cord-005453-4057qib7 2102 10 effect effect NN cord-005453-4057qib7 2102 11 modelling modelling NN cord-005453-4057qib7 2102 12 ( ( -LRB- cord-005453-4057qib7 2102 13 NONMEM NONMEM NNP cord-005453-4057qib7 2102 14 version version NN cord-005453-4057qib7 2102 15 7.3.0 7.3.0 NNP cord-005453-4057qib7 2102 16 , , , cord-005453-4057qib7 2102 17 using use VBG cord-005453-4057qib7 2102 18 PsN PsN NNP cord-005453-4057qib7 2102 19 toolkit toolkit NN cord-005453-4057qib7 2102 20 4.7.0 4.7.0 NNP cord-005453-4057qib7 2102 21 and and CC cord-005453-4057qib7 2102 22 Piraña Piraña NNP cord-005453-4057qib7 2102 23 version version NN cord-005453-4057qib7 2102 24 2.9.7 2.9.7 CD cord-005453-4057qib7 2102 25 as as IN cord-005453-4057qib7 2102 26 modelling modelling NN cord-005453-4057qib7 2102 27 environment environment NN cord-005453-4057qib7 2102 28 ) ) -RRB- cord-005453-4057qib7 2102 29 . . . cord-005453-4057qib7 2103 1 Demographic demographic JJ cord-005453-4057qib7 2103 2 factors factor NNS cord-005453-4057qib7 2103 3 , , , cord-005453-4057qib7 2103 4 as as RB cord-005453-4057qib7 2103 5 well well RB cord-005453-4057qib7 2103 6 as as IN cord-005453-4057qib7 2103 7 laboratory laboratory NN cord-005453-4057qib7 2103 8 parameters parameter NNS cord-005453-4057qib7 2103 9 , , , cord-005453-4057qib7 2103 10 were be VBD cord-005453-4057qib7 2103 11 included include VBN cord-005453-4057qib7 2103 12 as as IN cord-005453-4057qib7 2103 13 covariates covariate NNS cord-005453-4057qib7 2103 14 . . . cord-005453-4057qib7 2104 1 Results result NNS cord-005453-4057qib7 2104 2 : : : cord-005453-4057qib7 2105 1 Treosulfan Treosulfan NNP cord-005453-4057qib7 2105 2 PK PK NNP cord-005453-4057qib7 2105 3 was be VBD cord-005453-4057qib7 2105 4 best well RBS cord-005453-4057qib7 2105 5 described describe VBN cord-005453-4057qib7 2105 6 by by IN cord-005453-4057qib7 2105 7 a a DT cord-005453-4057qib7 2105 8 twocompartment twocompartment JJ cord-005453-4057qib7 2105 9 model model NN cord-005453-4057qib7 2105 10 . . . cord-005453-4057qib7 2106 1 A a DT cord-005453-4057qib7 2106 2 bodyweight bodyweight NN cord-005453-4057qib7 2106 3 - - HYPH cord-005453-4057qib7 2106 4 based base VBN cord-005453-4057qib7 2106 5 allometric allometric JJ cord-005453-4057qib7 2106 6 model model NN cord-005453-4057qib7 2106 7 improved improve VBD cord-005453-4057qib7 2106 8 the the DT cord-005453-4057qib7 2106 9 model model NN cord-005453-4057qib7 2106 10 more more JJR cord-005453-4057qib7 2106 11 than than IN cord-005453-4057qib7 2106 12 a a DT cord-005453-4057qib7 2106 13 model model NN cord-005453-4057qib7 2106 14 incorporating incorporate VBG cord-005453-4057qib7 2106 15 body body NN cord-005453-4057qib7 2106 16 surface surface NN cord-005453-4057qib7 2106 17 area area NN cord-005453-4057qib7 2106 18 ( ( -LRB- cord-005453-4057qib7 2106 19 BSA BSA NNP cord-005453-4057qib7 2106 20 ) ) -RRB- cord-005453-4057qib7 2106 21 . . . cord-005453-4057qib7 2107 1 Clearance clearance NN cord-005453-4057qib7 2107 2 ( ( -LRB- cord-005453-4057qib7 2107 3 CL CL NNP cord-005453-4057qib7 2107 4 ) ) -RRB- cord-005453-4057qib7 2107 5 and and CC cord-005453-4057qib7 2107 6 intercompartmental intercompartmental JJ cord-005453-4057qib7 2107 7 clearance clearance NN cord-005453-4057qib7 2107 8 parameters parameter NNS cord-005453-4057qib7 2107 9 were be VBD cord-005453-4057qib7 2107 10 6.07 6.07 CD cord-005453-4057qib7 2107 11 L L NNP cord-005453-4057qib7 2107 12 / / SYM cord-005453-4057qib7 2107 13 h/15.6 h/15.6 NNP cord-005453-4057qib7 2107 14 kg kg NNS cord-005453-4057qib7 2107 15 ( ( -LRB- cord-005453-4057qib7 2107 16 95%CI 95%ci CD cord-005453-4057qib7 2107 17 5.46 5.46 CD cord-005453-4057qib7 2107 18 - - HYPH cord-005453-4057qib7 2107 19 6.68 6.68 CD cord-005453-4057qib7 2107 20 ) ) -RRB- cord-005453-4057qib7 2107 21 and and CC cord-005453-4057qib7 2107 22 2.15 2.15 CD cord-005453-4057qib7 2107 23 L l NN cord-005453-4057qib7 2107 24 / / SYM cord-005453-4057qib7 2107 25 h h NN cord-005453-4057qib7 2107 26 ( ( -LRB- cord-005453-4057qib7 2107 27 95%CI 95%ci CD cord-005453-4057qib7 2107 28 1.39 1.39 CD cord-005453-4057qib7 2107 29 - - HYPH cord-005453-4057qib7 2107 30 2.91 2.91 CD cord-005453-4057qib7 2107 31 ) ) -RRB- cord-005453-4057qib7 2107 32 . . . cord-005453-4057qib7 2108 1 Typical typical JJ cord-005453-4057qib7 2108 2 volumes volume NNS cord-005453-4057qib7 2108 3 of of IN cord-005453-4057qib7 2108 4 distribution distribution NN cord-005453-4057qib7 2108 5 of of IN cord-005453-4057qib7 2108 6 the the DT cord-005453-4057qib7 2108 7 central central JJ cord-005453-4057qib7 2108 8 and and CC cord-005453-4057qib7 2108 9 peripheral peripheral JJ cord-005453-4057qib7 2108 10 compartments compartment NNS cord-005453-4057qib7 2108 11 were be VBD cord-005453-4057qib7 2108 12 8.00 8.00 CD cord-005453-4057qib7 2108 13 L/15.6 L/15.6 NNP cord-005453-4057qib7 2108 14 kg kg NNP cord-005453-4057qib7 2108 15 ( ( -LRB- cord-005453-4057qib7 2108 16 95%CI 95%ci CD cord-005453-4057qib7 2108 17 6.88 6.88 CD cord-005453-4057qib7 2108 18 - - HYPH cord-005453-4057qib7 2108 19 9.12 9.12 CD cord-005453-4057qib7 2108 20 ) ) -RRB- cord-005453-4057qib7 2108 21 and and CC cord-005453-4057qib7 2108 22 2.05 2.05 CD cord-005453-4057qib7 2108 23 L l NN cord-005453-4057qib7 2108 24 ( ( -LRB- cord-005453-4057qib7 2108 25 95%CI 95%ci CD cord-005453-4057qib7 2108 26 1.52 1.52 CD cord-005453-4057qib7 2108 27 - - HYPH cord-005453-4057qib7 2108 28 2.58 2.58 CD cord-005453-4057qib7 2108 29 ) ) -RRB- cord-005453-4057qib7 2108 30 . . . cord-005453-4057qib7 2109 1 A a DT cord-005453-4057qib7 2109 2 model model NN cord-005453-4057qib7 2109 3 - - HYPH cord-005453-4057qib7 2109 4 based base VBN cord-005453-4057qib7 2109 5 dosing dosing NN cord-005453-4057qib7 2109 6 table table NN cord-005453-4057qib7 2109 7 based base VBN cord-005453-4057qib7 2109 8 on on IN cord-005453-4057qib7 2109 9 bodyweight bodyweight NN cord-005453-4057qib7 2109 10 is be VBZ cord-005453-4057qib7 2109 11 created create VBN cord-005453-4057qib7 2109 12 to to TO cord-005453-4057qib7 2109 13 achieve achieve VB cord-005453-4057qib7 2109 14 a a DT cord-005453-4057qib7 2109 15 target target NN cord-005453-4057qib7 2109 16 exposure exposure NN cord-005453-4057qib7 2109 17 of of IN cord-005453-4057qib7 2109 18 1540 1540 CD cord-005453-4057qib7 2109 19 mg*hr mg*hr NNP cord-005453-4057qib7 2109 20 / / SYM cord-005453-4057qib7 2109 21 L L NNP cord-005453-4057qib7 2109 22 ( ( -LRB- cord-005453-4057qib7 2109 23 Table Table NNP cord-005453-4057qib7 2109 24 1 1 CD cord-005453-4057qib7 2109 25 ) ) -RRB- cord-005453-4057qib7 2109 26 , , , cord-005453-4057qib7 2109 27 which which WDT cord-005453-4057qib7 2109 28 was be VBD cord-005453-4057qib7 2109 29 the the DT cord-005453-4057qib7 2109 30 median median JJ cord-005453-4057qib7 2109 31 exposure exposure NN cord-005453-4057qib7 2109 32 of of IN cord-005453-4057qib7 2109 33 our -PRON- PRP$ cord-005453-4057qib7 2109 34 population population NN cord-005453-4057qib7 2109 35 . . . cord-005453-4057qib7 2110 1 Estimated estimate VBN cord-005453-4057qib7 2110 2 glomerular glomerular JJ cord-005453-4057qib7 2110 3 filtration filtration NN cord-005453-4057qib7 2110 4 rate rate NN cord-005453-4057qib7 2110 5 ( ( -LRB- cord-005453-4057qib7 2110 6 eGFR egfr NN cord-005453-4057qib7 2110 7 ) ) -RRB- cord-005453-4057qib7 2110 8 was be VBD cord-005453-4057qib7 2110 9 shown show VBN cord-005453-4057qib7 2110 10 to to TO cord-005453-4057qib7 2110 11 be be VB cord-005453-4057qib7 2110 12 the the DT cord-005453-4057qib7 2110 13 only only JJ cord-005453-4057qib7 2110 14 parameter parameter NN cord-005453-4057qib7 2110 15 that that WDT cord-005453-4057qib7 2110 16 significantly significantly RB cord-005453-4057qib7 2110 17 reduced reduce VBN cord-005453-4057qib7 2110 18 interpatient interpatient NN cord-005453-4057qib7 2110 19 variability variability NN cord-005453-4057qib7 2110 20 in in IN cord-005453-4057qib7 2110 21 CL CL NNP cord-005453-4057qib7 2110 22 from from IN cord-005453-4057qib7 2110 23 36.5 36.5 CD cord-005453-4057qib7 2110 24 % % NN cord-005453-4057qib7 2110 25 to to IN cord-005453-4057qib7 2110 26 34.8 34.8 CD cord-005453-4057qib7 2110 27 % % NN cord-005453-4057qib7 2110 28 . . . cord-005453-4057qib7 2111 1 A a DT cord-005453-4057qib7 2111 2 limited limited JJ cord-005453-4057qib7 2111 3 sampling sampling NN cord-005453-4057qib7 2111 4 model model NN cord-005453-4057qib7 2111 5 with with IN cord-005453-4057qib7 2111 6 3 3 CD cord-005453-4057qib7 2111 7 samples sample NNS cord-005453-4057qib7 2111 8 ( ( -LRB- cord-005453-4057qib7 2111 9 taken take VBN cord-005453-4057qib7 2111 10 at at IN cord-005453-4057qib7 2111 11 1.5 1.5 CD cord-005453-4057qib7 2111 12 , , , cord-005453-4057qib7 2111 13 4 4 CD cord-005453-4057qib7 2111 14 and and CC cord-005453-4057qib7 2111 15 7 7 CD cord-005453-4057qib7 2111 16 hours hour NNS cord-005453-4057qib7 2111 17 after after IN cord-005453-4057qib7 2111 18 start start NN cord-005453-4057qib7 2111 19 of of IN cord-005453-4057qib7 2111 20 infusion infusion NN cord-005453-4057qib7 2111 21 ) ) -RRB- cord-005453-4057qib7 2111 22 accurately accurately RB cord-005453-4057qib7 2111 23 estimated estimate VBN cord-005453-4057qib7 2111 24 pharmacokinetic pharmacokinetic JJ cord-005453-4057qib7 2111 25 parameters parameter NNS cord-005453-4057qib7 2111 26 of of IN cord-005453-4057qib7 2111 27 treosulfan treosulfan NNP cord-005453-4057qib7 2111 28 . . . cord-005453-4057qib7 2112 1 Conclusions conclusion NNS cord-005453-4057qib7 2112 2 : : : cord-005453-4057qib7 2113 1 To to IN cord-005453-4057qib7 2113 2 the the DT cord-005453-4057qib7 2113 3 best good JJS cord-005453-4057qib7 2113 4 of of IN cord-005453-4057qib7 2113 5 our -PRON- PRP$ cord-005453-4057qib7 2113 6 knowledge knowledge NN cord-005453-4057qib7 2113 7 , , , cord-005453-4057qib7 2113 8 this this DT cord-005453-4057qib7 2113 9 is be VBZ cord-005453-4057qib7 2113 10 the the DT cord-005453-4057qib7 2113 11 largest large JJS cord-005453-4057qib7 2113 12 cohort cohort NN cord-005453-4057qib7 2113 13 of of IN cord-005453-4057qib7 2113 14 pediatric pediatric JJ cord-005453-4057qib7 2113 15 patients patient NNS cord-005453-4057qib7 2113 16 treated treat VBN cord-005453-4057qib7 2113 17 with with IN cord-005453-4057qib7 2113 18 treosulfan treosulfan NNP cord-005453-4057qib7 2113 19 used use VBN cord-005453-4057qib7 2113 20 for for IN cord-005453-4057qib7 2113 21 a a DT cord-005453-4057qib7 2113 22 population population NN cord-005453-4057qib7 2113 23 pharmacokinetic pharmacokinetic JJ cord-005453-4057qib7 2113 24 study study NN cord-005453-4057qib7 2113 25 . . . cord-005453-4057qib7 2114 1 We -PRON- PRP cord-005453-4057qib7 2114 2 developed develop VBD cord-005453-4057qib7 2114 3 a a DT cord-005453-4057qib7 2114 4 two two CD cord-005453-4057qib7 2114 5 - - HYPH cord-005453-4057qib7 2114 6 compartment compartment NN cord-005453-4057qib7 2114 7 model model NN cord-005453-4057qib7 2114 8 with with IN cord-005453-4057qib7 2114 9 weight weight NN cord-005453-4057qib7 2114 10 and and CC cord-005453-4057qib7 2114 11 eGFR egfr NN cord-005453-4057qib7 2114 12 as as IN cord-005453-4057qib7 2114 13 covariates covariate NNS cord-005453-4057qib7 2114 14 influencing influence VBG cord-005453-4057qib7 2114 15 treosulfan treosulfan NNP cord-005453-4057qib7 2114 16 PK PK NNP cord-005453-4057qib7 2114 17 . . . cord-005453-4057qib7 2115 1 Recently recently RB cord-005453-4057qib7 2115 2 we -PRON- PRP cord-005453-4057qib7 2115 3 showed show VBD cord-005453-4057qib7 2115 4 a a DT cord-005453-4057qib7 2115 5 relationship relationship NN cord-005453-4057qib7 2115 6 between between IN cord-005453-4057qib7 2115 7 treosulfan treosulfan NNP cord-005453-4057qib7 2115 8 exposure exposure NN cord-005453-4057qib7 2115 9 and and CC cord-005453-4057qib7 2115 10 early early JJ cord-005453-4057qib7 2115 11 toxicity toxicity NN cord-005453-4057qib7 2115 12 . . . cord-005453-4057qib7 2116 1 Patients patient NNS cord-005453-4057qib7 2116 2 with with IN cord-005453-4057qib7 2116 3 an an DT cord-005453-4057qib7 2116 4 exposure exposure NN cord-005453-4057qib7 2116 5 > > XX cord-005453-4057qib7 2117 1 1650 1650 CD cord-005453-4057qib7 2117 2 mg*hr mg*hr NNP cord-005453-4057qib7 2117 3 / / SYM cord-005453-4057qib7 2117 4 L L NNP cord-005453-4057qib7 2117 5 have have VBP cord-005453-4057qib7 2117 6 an an DT cord-005453-4057qib7 2117 7 increased increase VBN cord-005453-4057qib7 2117 8 risk risk NN cord-005453-4057qib7 2117 9 of of IN cord-005453-4057qib7 2117 10 developing develop VBG cord-005453-4057qib7 2117 11 grade grade NN cord-005453-4057qib7 2117 12 2 2 CD cord-005453-4057qib7 2117 13 or or CC cord-005453-4057qib7 2117 14 higher high JJR cord-005453-4057qib7 2117 15 mucositis mucositis NN cord-005453-4057qib7 2117 16 and and CC cord-005453-4057qib7 2117 17 skin skin NN cord-005453-4057qib7 2117 18 toxicity toxicity NN cord-005453-4057qib7 2117 19 . . . cord-005453-4057qib7 2118 1 Another another DT cord-005453-4057qib7 2118 2 study study NN cord-005453-4057qib7 2118 3 in in IN cord-005453-4057qib7 2118 4 87 87 CD cord-005453-4057qib7 2118 5 pediatric pediatric JJ cord-005453-4057qib7 2118 6 patients patient NNS cord-005453-4057qib7 2118 7 with with IN cord-005453-4057qib7 2118 8 thalassemia thalassemia NN cord-005453-4057qib7 2118 9 major major NN cord-005453-4057qib7 2118 10 reported report VBD cord-005453-4057qib7 2118 11 an an DT cord-005453-4057qib7 2118 12 association association NN cord-005453-4057qib7 2118 13 between between IN cord-005453-4057qib7 2118 14 treosulfan treosulfan NNP cord-005453-4057qib7 2118 15 clearance clearance NN cord-005453-4057qib7 2118 16 ( ( -LRB- cord-005453-4057qib7 2118 17 < < NNP cord-005453-4057qib7 2118 18 7.97 7.97 CD cord-005453-4057qib7 2118 19 L L NNP cord-005453-4057qib7 2118 20 / / SYM cord-005453-4057qib7 2118 21 h h NN cord-005453-4057qib7 2118 22 / / SYM cord-005453-4057qib7 2118 23 m m NNP cord-005453-4057qib7 2118 24 2 2 CD cord-005453-4057qib7 2118 25 ) ) -RRB- cord-005453-4057qib7 2118 26 and and CC cord-005453-4057qib7 2118 27 poor poor JJ cord-005453-4057qib7 2118 28 overall overall JJ cord-005453-4057qib7 2118 29 survival survival NN cord-005453-4057qib7 2118 30 . . . cord-005453-4057qib7 2119 1 Our -PRON- PRP$ cord-005453-4057qib7 2119 2 model model NN cord-005453-4057qib7 2119 3 , , , cord-005453-4057qib7 2119 4 together together RB cord-005453-4057qib7 2119 5 with with IN cord-005453-4057qib7 2119 6 the the DT cord-005453-4057qib7 2119 7 limited limited JJ cord-005453-4057qib7 2119 8 sampling sampling NN cord-005453-4057qib7 2119 9 strategy strategy NN cord-005453-4057qib7 2119 10 , , , cord-005453-4057qib7 2119 11 can can MD cord-005453-4057qib7 2119 12 be be VB cord-005453-4057qib7 2119 13 used use VBN cord-005453-4057qib7 2119 14 to to TO cord-005453-4057qib7 2119 15 adjust adjust VB cord-005453-4057qib7 2119 16 the the DT cord-005453-4057qib7 2119 17 dose dose NN cord-005453-4057qib7 2119 18 , , , cord-005453-4057qib7 2119 19 prior prior RB cord-005453-4057qib7 2119 20 to to IN cord-005453-4057qib7 2119 21 or or CC cord-005453-4057qib7 2119 22 during during IN cord-005453-4057qib7 2119 23 treosulfan treosulfan NNP cord-005453-4057qib7 2119 24 administration administration NN cord-005453-4057qib7 2119 25 . . . cord-005453-4057qib7 2120 1 Ongoing ongoing JJ cord-005453-4057qib7 2120 2 studies study NNS cord-005453-4057qib7 2120 3 conducted conduct VBN cord-005453-4057qib7 2120 4 in in IN cord-005453-4057qib7 2120 5 different different JJ cord-005453-4057qib7 2120 6 disease disease NN cord-005453-4057qib7 2120 7 settings setting NNS cord-005453-4057qib7 2120 8 will will MD cord-005453-4057qib7 2120 9 determine determine VB cord-005453-4057qib7 2120 10 if if IN cord-005453-4057qib7 2120 11 treosulfan treosulfan NNP cord-005453-4057qib7 2120 12 exposure exposure NN cord-005453-4057qib7 2120 13 can can MD cord-005453-4057qib7 2120 14 influence influence VB cord-005453-4057qib7 2120 15 patient patient NN cord-005453-4057qib7 2120 16 outcome outcome NN cord-005453-4057qib7 2120 17 . . . cord-005453-4057qib7 2121 1 Subsequently subsequently RB cord-005453-4057qib7 2121 2 , , , cord-005453-4057qib7 2121 3 the the DT cord-005453-4057qib7 2121 4 optimal optimal JJ cord-005453-4057qib7 2121 5 target target NN cord-005453-4057qib7 2121 6 exposure exposure NN cord-005453-4057qib7 2121 7 can can MD cord-005453-4057qib7 2121 8 then then RB cord-005453-4057qib7 2121 9 be be VB cord-005453-4057qib7 2121 10 established establish VBN cord-005453-4057qib7 2121 11 . . . cord-005453-4057qib7 2122 1 Background background NN cord-005453-4057qib7 2122 2 : : : cord-005453-4057qib7 2123 1 Autologous autologous JJ cord-005453-4057qib7 2123 2 stem stem NN cord-005453-4057qib7 2123 3 cell cell NN cord-005453-4057qib7 2123 4 transplant transplant NN cord-005453-4057qib7 2123 5 ( ( -LRB- cord-005453-4057qib7 2123 6 ASCT ASCT NNP cord-005453-4057qib7 2123 7 ) ) -RRB- cord-005453-4057qib7 2123 8 is be VBZ cord-005453-4057qib7 2123 9 an an DT cord-005453-4057qib7 2123 10 effective effective JJ cord-005453-4057qib7 2123 11 treatment treatment NN cord-005453-4057qib7 2123 12 method method NN cord-005453-4057qib7 2123 13 for for IN cord-005453-4057qib7 2123 14 non non JJ cord-005453-4057qib7 2123 15 - - JJ cord-005453-4057qib7 2123 16 Hodgkin hodgkin JJ cord-005453-4057qib7 2123 17 lymphoma lymphoma NN cord-005453-4057qib7 2123 18 ( ( -LRB- cord-005453-4057qib7 2123 19 NHL NHL NNP cord-005453-4057qib7 2123 20 ) ) -RRB- cord-005453-4057qib7 2123 21 . . . cord-005453-4057qib7 2124 1 Until until IN cord-005453-4057qib7 2124 2 recently recently RB cord-005453-4057qib7 2124 3 , , , cord-005453-4057qib7 2124 4 carmustine carmustine NNP cord-005453-4057qib7 2124 5 , , , cord-005453-4057qib7 2124 6 etoposide etoposide RB cord-005453-4057qib7 2124 7 , , , cord-005453-4057qib7 2124 8 cytarabine cytarabine NNP cord-005453-4057qib7 2124 9 and and CC cord-005453-4057qib7 2124 10 melphalan melphalan NNP cord-005453-4057qib7 2124 11 ( ( -LRB- cord-005453-4057qib7 2124 12 BEAM BEAM NNP cord-005453-4057qib7 2124 13 ) ) -RRB- cord-005453-4057qib7 2124 14 was be VBD cord-005453-4057qib7 2124 15 the the DT cord-005453-4057qib7 2124 16 most most RBS cord-005453-4057qib7 2124 17 commonly commonly RB cord-005453-4057qib7 2124 18 used use VBN cord-005453-4057qib7 2124 19 conditioning conditioning NN cord-005453-4057qib7 2124 20 regimen regimen NN cord-005453-4057qib7 2124 21 . . . cord-005453-4057qib7 2125 1 Despite despite IN cord-005453-4057qib7 2125 2 acceptable acceptable JJ cord-005453-4057qib7 2125 3 efficacy efficacy NN cord-005453-4057qib7 2125 4 with with IN cord-005453-4057qib7 2125 5 BEAM BEAM NNP cord-005453-4057qib7 2125 6 , , , cord-005453-4057qib7 2125 7 carmustine carmustine NNP cord-005453-4057qib7 2125 8 is be VBZ cord-005453-4057qib7 2125 9 associated associate VBN cord-005453-4057qib7 2125 10 with with IN cord-005453-4057qib7 2125 11 major major JJ cord-005453-4057qib7 2125 12 pulmonary pulmonary JJ cord-005453-4057qib7 2125 13 toxicity toxicity NN cord-005453-4057qib7 2125 14 . . . cord-005453-4057qib7 2126 1 For for IN cord-005453-4057qib7 2126 2 this this DT cord-005453-4057qib7 2126 3 reason reason NN cord-005453-4057qib7 2126 4 , , , cord-005453-4057qib7 2126 5 the the DT cord-005453-4057qib7 2126 6 aim aim NN cord-005453-4057qib7 2126 7 of of IN cord-005453-4057qib7 2126 8 this this DT cord-005453-4057qib7 2126 9 study study NN cord-005453-4057qib7 2126 10 was be VBD cord-005453-4057qib7 2126 11 to to TO cord-005453-4057qib7 2126 12 investigate investigate VB cord-005453-4057qib7 2126 13 the the DT cord-005453-4057qib7 2126 14 safety safety NN cord-005453-4057qib7 2126 15 and and CC cord-005453-4057qib7 2126 16 efficacy efficacy NN cord-005453-4057qib7 2126 17 of of IN cord-005453-4057qib7 2126 18 BEB BEB NNP cord-005453-4057qib7 2126 19 conditioning condition VBG cord-005453-4057qib7 2126 20 regimen regimen NN cord-005453-4057qib7 2126 21 for for IN cord-005453-4057qib7 2126 22 ASCT ASCT NNP cord-005453-4057qib7 2126 23 in in IN cord-005453-4057qib7 2126 24 NHL NHL NNP cord-005453-4057qib7 2126 25 . . . cord-005453-4057qib7 2127 1 Methods method NNS cord-005453-4057qib7 2127 2 : : : cord-005453-4057qib7 2128 1 We -PRON- PRP cord-005453-4057qib7 2128 2 conducted conduct VBD cord-005453-4057qib7 2128 3 a a DT cord-005453-4057qib7 2128 4 prospective prospective JJ cord-005453-4057qib7 2128 5 , , , cord-005453-4057qib7 2128 6 multicenter multicenter JJ cord-005453-4057qib7 2128 7 , , , cord-005453-4057qib7 2128 8 phase phase NN cord-005453-4057qib7 2128 9 II ii CD cord-005453-4057qib7 2128 10 study study NN cord-005453-4057qib7 2128 11 for for IN cord-005453-4057qib7 2128 12 BEB BEB NNP cord-005453-4057qib7 2128 13 conditioning condition VBG cord-005453-4057qib7 2128 14 regimen regimen NN cord-005453-4057qib7 2128 15 for for IN cord-005453-4057qib7 2128 16 ASCT ASCT NNP cord-005453-4057qib7 2128 17 in in IN cord-005453-4057qib7 2128 18 NHL NHL NNP cord-005453-4057qib7 2128 19 patients patient NNS cord-005453-4057qib7 2128 20 . . . cord-005453-4057qib7 2129 1 A a DT cord-005453-4057qib7 2129 2 total total NN cord-005453-4057qib7 2129 3 of of IN cord-005453-4057qib7 2129 4 33 33 CD cord-005453-4057qib7 2129 5 patients patient NNS cord-005453-4057qib7 2129 6 were be VBD cord-005453-4057qib7 2129 7 enrolled enrol VBN cord-005453-4057qib7 2129 8 from from IN cord-005453-4057qib7 2129 9 3 3 CD cord-005453-4057qib7 2129 10 centers center NNS cord-005453-4057qib7 2129 11 . . . cord-005453-4057qib7 2130 1 They -PRON- PRP cord-005453-4057qib7 2130 2 underwent undergo VBD cord-005453-4057qib7 2130 3 ASCT ASCT NNP cord-005453-4057qib7 2130 4 with with IN cord-005453-4057qib7 2130 5 BEB BEB NNP cord-005453-4057qib7 2130 6 conditioning conditioning NN cord-005453-4057qib7 2130 7 regimen regimen NN cord-005453-4057qib7 2130 8 ( ( -LRB- cord-005453-4057qib7 2130 9 Busulfan Busulfan NNP cord-005453-4057qib7 2130 10 3.2mg 3.2mg NNP cord-005453-4057qib7 2130 11 / / SYM cord-005453-4057qib7 2130 12 kg kg NN cord-005453-4057qib7 2130 13 for for IN cord-005453-4057qib7 2130 14 3days 3days CD cord-005453-4057qib7 2130 15 , , , cord-005453-4057qib7 2130 16 Etoposide etoposide JJ cord-005453-4057qib7 2130 17 400mg/ 400mg/ CD cord-005453-4057qib7 2130 18 m m CD cord-005453-4057qib7 2130 19 2 2 CD cord-005453-4057qib7 2130 20 for for IN cord-005453-4057qib7 2130 21 2days 2days CD cord-005453-4057qib7 2130 22 , , , cord-005453-4057qib7 2130 23 Bendamustine Bendamustine NNP cord-005453-4057qib7 2130 24 200mg 200mg NNP cord-005453-4057qib7 2130 25 / / SYM cord-005453-4057qib7 2130 26 m m NN cord-005453-4057qib7 2130 27 2 2 CD cord-005453-4057qib7 2130 28 for for IN cord-005453-4057qib7 2130 29 2days 2days CD cord-005453-4057qib7 2130 30 ) ) -RRB- cord-005453-4057qib7 2130 31 between between IN cord-005453-4057qib7 2130 32 2016 2016 CD cord-005453-4057qib7 2130 33 and and CC cord-005453-4057qib7 2130 34 2018 2018 CD cord-005453-4057qib7 2130 35 . . . cord-005453-4057qib7 2131 1 [ [ -LRB- cord-005453-4057qib7 2131 2 [ [ -LRB- cord-005453-4057qib7 2131 3 P111 p111 JJ cord-005453-4057qib7 2131 4 Image image NN cord-005453-4057qib7 2131 5 ] ] -RRB- cord-005453-4057qib7 2131 6 1 1 CD cord-005453-4057qib7 2131 7 . . . cord-005453-4057qib7 2132 1 Two two CD cord-005453-4057qib7 2132 2 year year NN cord-005453-4057qib7 2132 3 progression progression NN cord-005453-4057qib7 2132 4 - - HYPH cord-005453-4057qib7 2132 5 free free JJ cord-005453-4057qib7 2132 6 survival survival NN cord-005453-4057qib7 2132 7 and and CC cord-005453-4057qib7 2132 8 overall overall JJ cord-005453-4057qib7 2132 9 survival survival NN cord-005453-4057qib7 2132 10 . . . cord-005453-4057qib7 2132 11 ] ] -RRB- cord-005453-4057qib7 2133 1 Results result NNS cord-005453-4057qib7 2133 2 : : : cord-005453-4057qib7 2133 3 The the DT cord-005453-4057qib7 2133 4 median median JJ cord-005453-4057qib7 2133 5 age age NN cord-005453-4057qib7 2133 6 was be VBD cord-005453-4057qib7 2133 7 52 52 CD cord-005453-4057qib7 2133 8 years year NNS cord-005453-4057qib7 2134 1 ( ( -LRB- cord-005453-4057qib7 2134 2 range range NNP cord-005453-4057qib7 2134 3 21 21 CD cord-005453-4057qib7 2134 4 - - SYM cord-005453-4057qib7 2134 5 66 66 CD cord-005453-4057qib7 2134 6 ) ) -RRB- cord-005453-4057qib7 2134 7 and and CC cord-005453-4057qib7 2134 8 16 16 CD cord-005453-4057qib7 2134 9 patients patient NNS cord-005453-4057qib7 2134 10 ( ( -LRB- cord-005453-4057qib7 2134 11 48.5 48.5 CD cord-005453-4057qib7 2134 12 % % NN cord-005453-4057qib7 2134 13 ) ) -RRB- cord-005453-4057qib7 2134 14 were be VBD cord-005453-4057qib7 2134 15 men man NNS cord-005453-4057qib7 2134 16 . . . cord-005453-4057qib7 2135 1 The the DT cord-005453-4057qib7 2135 2 most most RBS cord-005453-4057qib7 2135 3 common common JJ cord-005453-4057qib7 2135 4 type type NN cord-005453-4057qib7 2135 5 was be VBD cord-005453-4057qib7 2135 6 diffuse diffuse JJ cord-005453-4057qib7 2135 7 large large JJ cord-005453-4057qib7 2135 8 B b NN cord-005453-4057qib7 2135 9 cell cell NN cord-005453-4057qib7 2135 10 lymphoma lymphoma NN cord-005453-4057qib7 2135 11 ( ( -LRB- cord-005453-4057qib7 2135 12 n=23 n=23 NNP cord-005453-4057qib7 2135 13 , , , cord-005453-4057qib7 2135 14 69.7 69.7 CD cord-005453-4057qib7 2135 15 % % NN cord-005453-4057qib7 2135 16 ) ) -RRB- cord-005453-4057qib7 2135 17 and and CC cord-005453-4057qib7 2135 18 more more JJR cord-005453-4057qib7 2135 19 than than IN cord-005453-4057qib7 2135 20 half half NN cord-005453-4057qib7 2135 21 of of IN cord-005453-4057qib7 2135 22 patients patient NNS cord-005453-4057qib7 2135 23 ( ( -LRB- cord-005453-4057qib7 2135 24 n=19 n=19 JJ cord-005453-4057qib7 2135 25 , , , cord-005453-4057qib7 2135 26 57.6 57.6 CD cord-005453-4057qib7 2135 27 % % NN cord-005453-4057qib7 2135 28 ) ) -RRB- cord-005453-4057qib7 2135 29 were be VBD cord-005453-4057qib7 2135 30 classified classify VBN cord-005453-4057qib7 2135 31 as as IN cord-005453-4057qib7 2135 32 IPI IPI NNP cord-005453-4057qib7 2135 33 score score NN cord-005453-4057qib7 2135 34 3 3 CD cord-005453-4057qib7 2135 35 or or CC cord-005453-4057qib7 2135 36 4 4 CD cord-005453-4057qib7 2135 37 . . . cord-005453-4057qib7 2136 1 Eight eight CD cord-005453-4057qib7 2136 2 patients patient NNS cord-005453-4057qib7 2136 3 ( ( -LRB- cord-005453-4057qib7 2136 4 27.3 27.3 CD cord-005453-4057qib7 2136 5 % % NN cord-005453-4057qib7 2136 6 ) ) -RRB- cord-005453-4057qib7 2136 7 had have VBD cord-005453-4057qib7 2136 8 a a DT cord-005453-4057qib7 2136 9 history history NN cord-005453-4057qib7 2136 10 of of IN cord-005453-4057qib7 2136 11 relapse relapse NN cord-005453-4057qib7 2136 12 and and CC cord-005453-4057qib7 2136 13 19 19 CD cord-005453-4057qib7 2136 14 patients patient NNS cord-005453-4057qib7 2136 15 ( ( -LRB- cord-005453-4057qib7 2136 16 57.6 57.6 CD cord-005453-4057qib7 2136 17 % % NN cord-005453-4057qib7 2136 18 ) ) -RRB- cord-005453-4057qib7 2136 19 received receive VBD cord-005453-4057qib7 2136 20 more more JJR cord-005453-4057qib7 2136 21 than than IN cord-005453-4057qib7 2136 22 2 2 CD cord-005453-4057qib7 2136 23 lines line NNS cord-005453-4057qib7 2136 24 of of IN cord-005453-4057qib7 2136 25 chemotherapy chemotherapy NN cord-005453-4057qib7 2136 26 before before IN cord-005453-4057qib7 2136 27 ASCT ASCT NNP cord-005453-4057qib7 2136 28 . . . cord-005453-4057qib7 2137 1 Most Most JJS cord-005453-4057qib7 2137 2 patients patient NNS cord-005453-4057qib7 2137 3 ( ( -LRB- cord-005453-4057qib7 2137 4 n=27 n=27 FW cord-005453-4057qib7 2137 5 , , , cord-005453-4057qib7 2137 6 81.8 81.8 CD cord-005453-4057qib7 2137 7 % % NN cord-005453-4057qib7 2137 8 ) ) -RRB- cord-005453-4057qib7 2137 9 were be VBD cord-005453-4057qib7 2137 10 complete complete JJ cord-005453-4057qib7 2137 11 remission remission NN cord-005453-4057qib7 2137 12 ( ( -LRB- cord-005453-4057qib7 2137 13 CR cr NN cord-005453-4057qib7 2137 14 ) ) -RRB- cord-005453-4057qib7 2137 15 state state NN cord-005453-4057qib7 2137 16 at at IN cord-005453-4057qib7 2137 17 ASCT ASCT NNP cord-005453-4057qib7 2137 18 . . . cord-005453-4057qib7 2138 1 A a DT cord-005453-4057qib7 2138 2 median median JJ cord-005453-4057qib7 2138 3 number number NN cord-005453-4057qib7 2138 4 of of IN cord-005453-4057qib7 2138 5 5.85x10 5.85x10 CD cord-005453-4057qib7 2138 6 6 6 CD cord-005453-4057qib7 2138 7 /kg /kg . cord-005453-4057qib7 2139 1 CD34 CD34 NNP cord-005453-4057qib7 2139 2 cells cell NNS cord-005453-4057qib7 2139 3 were be VBD cord-005453-4057qib7 2139 4 infused infuse VBN cord-005453-4057qib7 2139 5 ( ( -LRB- cord-005453-4057qib7 2139 6 range range NNP cord-005453-4057qib7 2139 7 2.0 2.0 CD cord-005453-4057qib7 2139 8 - - HYPH cord-005453-4057qib7 2139 9 18.6 18.6 CD cord-005453-4057qib7 2139 10 ) ) -RRB- cord-005453-4057qib7 2139 11 . . . cord-005453-4057qib7 2140 1 All all DT cord-005453-4057qib7 2140 2 patients patient NNS cord-005453-4057qib7 2140 3 engrafted engraft VBN cord-005453-4057qib7 2140 4 after after IN cord-005453-4057qib7 2140 5 a a DT cord-005453-4057qib7 2140 6 median median JJ cord-005453-4057qib7 2140 7 time time NN cord-005453-4057qib7 2140 8 of of IN cord-005453-4057qib7 2140 9 11 11 CD cord-005453-4057qib7 2140 10 days day NNS cord-005453-4057qib7 2140 11 ( ( -LRB- cord-005453-4057qib7 2140 12 range range VBP cord-005453-4057qib7 2140 13 10 10 CD cord-005453-4057qib7 2140 14 - - SYM cord-005453-4057qib7 2140 15 14 14 CD cord-005453-4057qib7 2140 16 ) ) -RRB- cord-005453-4057qib7 2140 17 . . . cord-005453-4057qib7 2141 1 Twelve twelve CD cord-005453-4057qib7 2141 2 patients patient NNS cord-005453-4057qib7 2141 3 ( ( -LRB- cord-005453-4057qib7 2141 4 36.4 36.4 CD cord-005453-4057qib7 2141 5 % % NN cord-005453-4057qib7 2141 6 ) ) -RRB- cord-005453-4057qib7 2141 7 experienced experience VBD cord-005453-4057qib7 2141 8 neutropenic neutropenic JJ cord-005453-4057qib7 2141 9 fever fever NN cord-005453-4057qib7 2141 10 and and CC cord-005453-4057qib7 2141 11 16 16 CD cord-005453-4057qib7 2141 12 patients patient NNS cord-005453-4057qib7 2141 13 ( ( -LRB- cord-005453-4057qib7 2141 14 48.5 48.5 CD cord-005453-4057qib7 2141 15 % % NN cord-005453-4057qib7 2141 16 ) ) -RRB- cord-005453-4057qib7 2141 17 had have VBD cord-005453-4057qib7 2141 18 grade grade NN cord-005453-4057qib7 2141 19 3 3 CD cord-005453-4057qib7 2141 20 toxicities toxicity NNS cord-005453-4057qib7 2141 21 during during IN cord-005453-4057qib7 2141 22 ASCT ASCT NNP cord-005453-4057qib7 2141 23 . . . cord-005453-4057qib7 2142 1 However however RB cord-005453-4057qib7 2142 2 , , , cord-005453-4057qib7 2142 3 no no DT cord-005453-4057qib7 2142 4 one one NN cord-005453-4057qib7 2142 5 had have VBD cord-005453-4057qib7 2142 6 a a DT cord-005453-4057qib7 2142 7 documented document VBN cord-005453-4057qib7 2142 8 infection infection NN cord-005453-4057qib7 2142 9 , , , cord-005453-4057qib7 2142 10 veno veno NNP cord-005453-4057qib7 2142 11 - - HYPH cord-005453-4057qib7 2142 12 occlusive occlusive JJ cord-005453-4057qib7 2142 13 disease disease NN cord-005453-4057qib7 2142 14 , , , cord-005453-4057qib7 2142 15 or or CC cord-005453-4057qib7 2142 16 treatment treatment NN cord-005453-4057qib7 2142 17 - - HYPH cord-005453-4057qib7 2142 18 related relate VBN cord-005453-4057qib7 2142 19 death death NN cord-005453-4057qib7 2142 20 . . . cord-005453-4057qib7 2143 1 Three three CD cord-005453-4057qib7 2143 2 months month NNS cord-005453-4057qib7 2143 3 CR cr NN cord-005453-4057qib7 2143 4 rate rate NN cord-005453-4057qib7 2143 5 was be VBD cord-005453-4057qib7 2143 6 81.8 81.8 CD cord-005453-4057qib7 2143 7 % % NN cord-005453-4057qib7 2143 8 . . . cord-005453-4057qib7 2144 1 During during IN cord-005453-4057qib7 2144 2 a a DT cord-005453-4057qib7 2144 3 median median JJ cord-005453-4057qib7 2144 4 follow follow NN cord-005453-4057qib7 2144 5 - - HYPH cord-005453-4057qib7 2144 6 up up NN cord-005453-4057qib7 2144 7 period period NN cord-005453-4057qib7 2144 8 of of IN cord-005453-4057qib7 2144 9 10.2 10.2 CD cord-005453-4057qib7 2144 10 month month NN cord-005453-4057qib7 2144 11 , , , cord-005453-4057qib7 2144 12 7 7 CD cord-005453-4057qib7 2144 13 patients patient NNS cord-005453-4057qib7 2144 14 ( ( -LRB- cord-005453-4057qib7 2144 15 21.2 21.2 CD cord-005453-4057qib7 2144 16 % % NN cord-005453-4057qib7 2144 17 ) ) -RRB- cord-005453-4057qib7 2144 18 exhibited exhibit VBN cord-005453-4057qib7 2144 19 relapse relapse NN cord-005453-4057qib7 2144 20 or or CC cord-005453-4057qib7 2144 21 progression progression NN cord-005453-4057qib7 2144 22 , , , cord-005453-4057qib7 2144 23 while while IN cord-005453-4057qib7 2144 24 1 1 CD cord-005453-4057qib7 2144 25 patient patient NN cord-005453-4057qib7 2144 26 ( ( -LRB- cord-005453-4057qib7 2144 27 3.0 3.0 CD cord-005453-4057qib7 2144 28 % % NN cord-005453-4057qib7 2144 29 ) ) -RRB- cord-005453-4057qib7 2144 30 died die VBD cord-005453-4057qib7 2144 31 of of IN cord-005453-4057qib7 2144 32 the the DT cord-005453-4057qib7 2144 33 disease disease NN cord-005453-4057qib7 2144 34 . . . cord-005453-4057qib7 2145 1 The the DT cord-005453-4057qib7 2145 2 estimated estimate VBN cord-005453-4057qib7 2145 3 2-year 2-year CD cord-005453-4057qib7 2145 4 PFS PFS NNP cord-005453-4057qib7 2145 5 and and CC cord-005453-4057qib7 2145 6 OS OS NNP cord-005453-4057qib7 2145 7 rate rate NN cord-005453-4057qib7 2145 8 were be VBD cord-005453-4057qib7 2145 9 73.0 73.0 CD cord-005453-4057qib7 2145 10 % % NN cord-005453-4057qib7 2145 11 and and CC cord-005453-4057qib7 2145 12 89.8 89.8 CD cord-005453-4057qib7 2145 13 % % NN cord-005453-4057qib7 2145 14 , , , cord-005453-4057qib7 2145 15 respectively respectively RB cord-005453-4057qib7 2146 1 ( ( -LRB- cord-005453-4057qib7 2146 2 Figure figure NN cord-005453-4057qib7 2146 3 1 1 CD cord-005453-4057qib7 2146 4 ) ) -RRB- cord-005453-4057qib7 2146 5 . . . cord-005453-4057qib7 2147 1 Conclusions conclusion NNS cord-005453-4057qib7 2147 2 : : : cord-005453-4057qib7 2148 1 The the DT cord-005453-4057qib7 2148 2 BEB BEB NNP cord-005453-4057qib7 2148 3 conditioning condition VBG cord-005453-4057qib7 2148 4 regimens regimen NNS cord-005453-4057qib7 2148 5 for for IN cord-005453-4057qib7 2148 6 ASCT ASCT NNP cord-005453-4057qib7 2148 7 is be VBZ cord-005453-4057qib7 2148 8 a a DT cord-005453-4057qib7 2148 9 feasible feasible JJ cord-005453-4057qib7 2148 10 with with IN cord-005453-4057qib7 2148 11 tolerable tolerable JJ cord-005453-4057qib7 2148 12 toxicity toxicity NN cord-005453-4057qib7 2148 13 in in IN cord-005453-4057qib7 2148 14 patients patient NNS cord-005453-4057qib7 2148 15 with with IN cord-005453-4057qib7 2148 16 NHL NHL NNP cord-005453-4057qib7 2148 17 . . . cord-005453-4057qib7 2149 1 Disclosure disclosure NN cord-005453-4057qib7 2149 2 : : : cord-005453-4057qib7 2149 3 Nothing nothing NN cord-005453-4057qib7 2149 4 to to TO cord-005453-4057qib7 2149 5 declare declare VB cord-005453-4057qib7 2149 6 Long long JJ cord-005453-4057qib7 2149 7 - - HYPH cord-005453-4057qib7 2149 8 term term NN cord-005453-4057qib7 2149 9 report report NN cord-005453-4057qib7 2149 10 of of IN cord-005453-4057qib7 2149 11 total total JJ cord-005453-4057qib7 2149 12 marrow marrow NN cord-005453-4057qib7 2149 13 or or CC cord-005453-4057qib7 2149 14 total total JJ cord-005453-4057qib7 2149 15 lymphoid lymphoid JJ cord-005453-4057qib7 2149 16 IMRT IMRT NNP cord-005453-4057qib7 2149 17 in in IN cord-005453-4057qib7 2149 18 advanced advanced JJ cord-005453-4057qib7 2149 19 leukemia leukemia NN cord-005453-4057qib7 2149 20 , , , cord-005453-4057qib7 2149 21 myeloma myeloma NN cord-005453-4057qib7 2149 22 and and CC cord-005453-4057qib7 2149 23 lymphoma lymphoma NN cord-005453-4057qib7 2149 24 Background background NN cord-005453-4057qib7 2149 25 : : : cord-005453-4057qib7 2149 26 During during IN cord-005453-4057qib7 2149 27 the the DT cord-005453-4057qib7 2149 28 last last JJ cord-005453-4057qib7 2149 29 three three CD cord-005453-4057qib7 2149 30 decades decade NNS cord-005453-4057qib7 2149 31 , , , cord-005453-4057qib7 2149 32 total total JJ cord-005453-4057qib7 2149 33 body body NN cord-005453-4057qib7 2149 34 irradiation irradiation NN cord-005453-4057qib7 2149 35 ( ( -LRB- cord-005453-4057qib7 2149 36 TBI TBI NNP cord-005453-4057qib7 2149 37 ) ) -RRB- cord-005453-4057qib7 2149 38 continues continue VBZ cord-005453-4057qib7 2149 39 to to TO cord-005453-4057qib7 2149 40 play play VB cord-005453-4057qib7 2149 41 an an DT cord-005453-4057qib7 2149 42 important important JJ cord-005453-4057qib7 2149 43 role role NN cord-005453-4057qib7 2149 44 in in IN cord-005453-4057qib7 2149 45 the the DT cord-005453-4057qib7 2149 46 conditioning conditioning NN cord-005453-4057qib7 2149 47 regimens regimen NNS cord-005453-4057qib7 2149 48 for for IN cord-005453-4057qib7 2149 49 patients patient NNS cord-005453-4057qib7 2149 50 undergoing undergo VBG cord-005453-4057qib7 2149 51 stem stem NN cord-005453-4057qib7 2149 52 - - HYPH cord-005453-4057qib7 2149 53 cell cell NN cord-005453-4057qib7 2149 54 transplant transplant NN cord-005453-4057qib7 2149 55 ( ( -LRB- cord-005453-4057qib7 2149 56 SCT SCT NNP cord-005453-4057qib7 2149 57 ) ) -RRB- cord-005453-4057qib7 2149 58 for for IN cord-005453-4057qib7 2149 59 a a DT cord-005453-4057qib7 2149 60 wide wide JJ cord-005453-4057qib7 2149 61 variety variety NN cord-005453-4057qib7 2149 62 of of IN cord-005453-4057qib7 2149 63 advanced advanced JJ cord-005453-4057qib7 2149 64 hematological hematological JJ cord-005453-4057qib7 2149 65 malignancies malignancy NNS cord-005453-4057qib7 2149 66 . . . cord-005453-4057qib7 2150 1 However however RB cord-005453-4057qib7 2150 2 , , , cord-005453-4057qib7 2150 3 TBI TBI NNP cord-005453-4057qib7 2150 4 showed show VBD cord-005453-4057qib7 2150 5 boundaries boundary NNS cord-005453-4057qib7 2150 6 in in IN cord-005453-4057qib7 2150 7 dose dose NN cord-005453-4057qib7 2150 8 limits limit NNS cord-005453-4057qib7 2150 9 for for IN cord-005453-4057qib7 2150 10 toxicity toxicity NN cord-005453-4057qib7 2150 11 in in IN cord-005453-4057qib7 2150 12 allogenic allogenic NN cord-005453-4057qib7 2150 13 and and CC cord-005453-4057qib7 2150 14 moreover moreover RB cord-005453-4057qib7 2150 15 in in IN cord-005453-4057qib7 2150 16 autologous autologous JJ cord-005453-4057qib7 2150 17 stem stem NN cord-005453-4057qib7 2150 18 cell cell NN cord-005453-4057qib7 2150 19 transplantation transplantation NN cord-005453-4057qib7 2150 20 . . . cord-005453-4057qib7 2151 1 Currently currently RB cord-005453-4057qib7 2151 2 , , , cord-005453-4057qib7 2151 3 the the DT cord-005453-4057qib7 2151 4 choice choice NN cord-005453-4057qib7 2151 5 of of IN cord-005453-4057qib7 2151 6 conditioning conditioning NN cord-005453-4057qib7 2151 7 regimen regimen NN cord-005453-4057qib7 2151 8 is be VBZ cord-005453-4057qib7 2151 9 based base VBN cord-005453-4057qib7 2151 10 on on IN cord-005453-4057qib7 2151 11 the the DT cord-005453-4057qib7 2151 12 use use NN cord-005453-4057qib7 2151 13 of of IN cord-005453-4057qib7 2151 14 the the DT cord-005453-4057qib7 2151 15 least least JJS cord-005453-4057qib7 2151 16 - - HYPH cord-005453-4057qib7 2151 17 toxic toxic JJ cord-005453-4057qib7 2151 18 regimen regimen NN cord-005453-4057qib7 2151 19 to to TO cord-005453-4057qib7 2151 20 achieve achieve VB cord-005453-4057qib7 2151 21 the the DT cord-005453-4057qib7 2151 22 optimal optimal JJ cord-005453-4057qib7 2151 23 therapeutic therapeutic JJ cord-005453-4057qib7 2151 24 result result NN cord-005453-4057qib7 2151 25 . . . cord-005453-4057qib7 2152 1 This this DT cord-005453-4057qib7 2152 2 report report NN cord-005453-4057qib7 2152 3 aims aim VBZ cord-005453-4057qib7 2152 4 to to TO cord-005453-4057qib7 2152 5 assess assess VB cord-005453-4057qib7 2152 6 the the DT cord-005453-4057qib7 2152 7 feasibility feasibility NN cord-005453-4057qib7 2152 8 of of IN cord-005453-4057qib7 2152 9 a a DT cord-005453-4057qib7 2152 10 conditioning conditioning NN cord-005453-4057qib7 2152 11 strategy strategy NN cord-005453-4057qib7 2152 12 based base VBN cord-005453-4057qib7 2152 13 on on IN cord-005453-4057qib7 2152 14 high high JJ cord-005453-4057qib7 2152 15 dose dose NN cord-005453-4057qib7 2152 16 chemotherapy chemotherapy NN cord-005453-4057qib7 2152 17 and and CC cord-005453-4057qib7 2152 18 whole whole JJ cord-005453-4057qib7 2152 19 - - HYPH cord-005453-4057qib7 2152 20 body body NN cord-005453-4057qib7 2152 21 radiotherapy radiotherapy NN cord-005453-4057qib7 2152 22 focused focus VBD cord-005453-4057qib7 2152 23 on on IN cord-005453-4057qib7 2152 24 selective selective JJ cord-005453-4057qib7 2152 25 extensive extensive JJ cord-005453-4057qib7 2152 26 tumor tumor NN cord-005453-4057qib7 2152 27 burden burden NN cord-005453-4057qib7 2152 28 irradiation irradiation NN cord-005453-4057qib7 2152 29 , , , cord-005453-4057qib7 2152 30 both both CC cord-005453-4057qib7 2152 31 in in IN cord-005453-4057qib7 2152 32 allogeneic allogeneic NN cord-005453-4057qib7 2152 33 and and CC cord-005453-4057qib7 2152 34 autologous autologous JJ cord-005453-4057qib7 2152 35 stem stem NN cord-005453-4057qib7 2152 36 cell cell NN cord-005453-4057qib7 2152 37 transplantation transplantation NN cord-005453-4057qib7 2152 38 . . . cord-005453-4057qib7 2153 1 Methods method NNS cord-005453-4057qib7 2153 2 : : : cord-005453-4057qib7 2153 3 Since since IN cord-005453-4057qib7 2153 4 December December NNP cord-005453-4057qib7 2153 5 2009 2009 CD cord-005453-4057qib7 2153 6 , , , cord-005453-4057qib7 2153 7 sixty sixty CD cord-005453-4057qib7 2153 8 - - HYPH cord-005453-4057qib7 2153 9 two two CD cord-005453-4057qib7 2153 10 patients patient NNS cord-005453-4057qib7 2153 11 ( ( -LRB- cord-005453-4057qib7 2153 12 pts pt NNS cord-005453-4057qib7 2153 13 ) ) -RRB- cord-005453-4057qib7 2153 14 have have VBP cord-005453-4057qib7 2153 15 been be VBN cord-005453-4057qib7 2153 16 irradiated irradiate VBN cord-005453-4057qib7 2153 17 by by IN cord-005453-4057qib7 2153 18 helical helical JJ cord-005453-4057qib7 2153 19 tomotherapy tomotherapy NN cord-005453-4057qib7 2153 20 ( ( -LRB- cord-005453-4057qib7 2153 21 HT HT NNP cord-005453-4057qib7 2153 22 ) ) -RRB- cord-005453-4057qib7 2153 23 to to TO cord-005453-4057qib7 2153 24 extensive extensive JJ cord-005453-4057qib7 2153 25 target target NN cord-005453-4057qib7 2153 26 before before IN cord-005453-4057qib7 2153 27 allogeneic allogeneic NN cord-005453-4057qib7 2153 28 or or CC cord-005453-4057qib7 2153 29 autologous autologous JJ cord-005453-4057qib7 2153 30 transplantation transplantation NN cord-005453-4057qib7 2153 31 . . . cord-005453-4057qib7 2154 1 Selected select VBN cord-005453-4057qib7 2154 2 total total JJ cord-005453-4057qib7 2154 3 marrow marrow NN cord-005453-4057qib7 2154 4 irradiation irradiation NN cord-005453-4057qib7 2154 5 ( ( -LRB- cord-005453-4057qib7 2154 6 TMI TMI NNP cord-005453-4057qib7 2154 7 ) ) -RRB- cord-005453-4057qib7 2154 8 schedules schedule NNS cord-005453-4057qib7 2154 9 were be VBD cord-005453-4057qib7 2154 10 planned plan VBN cord-005453-4057qib7 2154 11 to to TO cord-005453-4057qib7 2154 12 treat treat VB cord-005453-4057qib7 2154 13 patients patient NNS cord-005453-4057qib7 2154 14 with with IN cord-005453-4057qib7 2154 15 high high JJ cord-005453-4057qib7 2154 16 risk risk NN cord-005453-4057qib7 2154 17 acute acute JJ cord-005453-4057qib7 2154 18 leukemia leukemia NN cord-005453-4057qib7 2154 19 ( ( -LRB- cord-005453-4057qib7 2154 20 ALL all DT cord-005453-4057qib7 2154 21 or or CC cord-005453-4057qib7 2154 22 AML AML NNP cord-005453-4057qib7 2154 23 ) ) -RRB- cord-005453-4057qib7 2154 24 or or CC cord-005453-4057qib7 2154 25 multiple multiple JJ cord-005453-4057qib7 2154 26 myeloma myeloma NN cord-005453-4057qib7 2154 27 ( ( -LRB- cord-005453-4057qib7 2154 28 MM MM NNP cord-005453-4057qib7 2154 29 ) ) -RRB- cord-005453-4057qib7 2154 30 as as IN cord-005453-4057qib7 2154 31 a a DT cord-005453-4057qib7 2154 32 part part NN cord-005453-4057qib7 2154 33 of of IN cord-005453-4057qib7 2154 34 conditioning conditioning NN cord-005453-4057qib7 2154 35 regimen regimen NN cord-005453-4057qib7 2154 36 . . . cord-005453-4057qib7 2155 1 Total total JJ cord-005453-4057qib7 2155 2 lymphoid lymphoid JJ cord-005453-4057qib7 2155 3 irradiation irradiation NN cord-005453-4057qib7 2155 4 ( ( -LRB- cord-005453-4057qib7 2155 5 TLI TLI NNP cord-005453-4057qib7 2155 6 ) ) -RRB- cord-005453-4057qib7 2155 7 was be VBD cord-005453-4057qib7 2155 8 planned plan VBN cord-005453-4057qib7 2155 9 for for IN cord-005453-4057qib7 2155 10 patients patient NNS cord-005453-4057qib7 2155 11 with with IN cord-005453-4057qib7 2155 12 refractory refractory JJ cord-005453-4057qib7 2155 13 or or CC cord-005453-4057qib7 2155 14 relapsed relapsed JJ cord-005453-4057qib7 2155 15 ( ( -LRB- cord-005453-4057qib7 2155 16 R r NN cord-005453-4057qib7 2155 17 / / SYM cord-005453-4057qib7 2155 18 R r NN cord-005453-4057qib7 2155 19 ) ) -RRB- cord-005453-4057qib7 2155 20 Hodgkin Hodgkin NNP cord-005453-4057qib7 2155 21 ( ( -LRB- cord-005453-4057qib7 2155 22 HD HD NNP cord-005453-4057qib7 2155 23 ) ) -RRB- cord-005453-4057qib7 2155 24 or or CC cord-005453-4057qib7 2155 25 Non Non NNP cord-005453-4057qib7 2155 26 - - JJ cord-005453-4057qib7 2155 27 Hodgkin Hodgkin NNP cord-005453-4057qib7 2155 28 lymphomas lymphoma NNS cord-005453-4057qib7 2155 29 ( ( -LRB- cord-005453-4057qib7 2155 30 NHL NHL NNP cord-005453-4057qib7 2155 31 ) ) -RRB- cord-005453-4057qib7 2155 32 . . . cord-005453-4057qib7 2156 1 Results result NNS cord-005453-4057qib7 2156 2 : : : cord-005453-4057qib7 2157 1 TMI TMI NNP cord-005453-4057qib7 2157 2 and and CC cord-005453-4057qib7 2157 3 TLI TLI NNP cord-005453-4057qib7 2157 4 allowed allow VBD cord-005453-4057qib7 2157 5 delivering deliver VBG cord-005453-4057qib7 2157 6 therapeutic therapeutic JJ cord-005453-4057qib7 2157 7 dose dose NN cord-005453-4057qib7 2157 8 over over IN cord-005453-4057qib7 2157 9 extensive extensive JJ cord-005453-4057qib7 2157 10 selected select VBN cord-005453-4057qib7 2157 11 targets target NNS cord-005453-4057qib7 2157 12 with with IN cord-005453-4057qib7 2157 13 wide wide JJ cord-005453-4057qib7 2157 14 reduction reduction NN cord-005453-4057qib7 2157 15 of of IN cord-005453-4057qib7 2157 16 toxicity toxicity NN cord-005453-4057qib7 2157 17 to to IN cord-005453-4057qib7 2157 18 all all PDT cord-005453-4057qib7 2157 19 the the DT cord-005453-4057qib7 2157 20 organs organ NNS cord-005453-4057qib7 2157 21 at at IN cord-005453-4057qib7 2157 22 risk risk NN cord-005453-4057qib7 2157 23 ( ( -LRB- cord-005453-4057qib7 2157 24 OARs OARs NNP cord-005453-4057qib7 2157 25 ) ) -RRB- cord-005453-4057qib7 2157 26 . . . cord-005453-4057qib7 2158 1 The the DT cord-005453-4057qib7 2158 2 higher high JJR cord-005453-4057qib7 2158 3 radiation radiation NN cord-005453-4057qib7 2158 4 doses dose NNS cord-005453-4057qib7 2158 5 rate rate NN cord-005453-4057qib7 2158 6 to to IN cord-005453-4057qib7 2158 7 the the DT cord-005453-4057qib7 2158 8 OARs oars NN cord-005453-4057qib7 2158 9 is be VBZ cord-005453-4057qib7 2158 10 reduced reduce VBN cord-005453-4057qib7 2158 11 from from IN cord-005453-4057qib7 2158 12 30 30 CD cord-005453-4057qib7 2158 13 % % NN cord-005453-4057qib7 2158 14 to to TO cord-005453-4057qib7 2158 15 70 70 CD cord-005453-4057qib7 2158 16 % % NN cord-005453-4057qib7 2158 17 . . . cord-005453-4057qib7 2159 1 Allogenic allogenic JJ cord-005453-4057qib7 2159 2 conditioning conditioning NN cord-005453-4057qib7 2159 3 regimen regimen NN cord-005453-4057qib7 2159 4 was be VBD cord-005453-4057qib7 2159 5 TLI TLI NNP cord-005453-4057qib7 2159 6 ( ( -LRB- cord-005453-4057qib7 2159 7 4Gy 4gy JJ cord-005453-4057qib7 2159 8 x x SYM cord-005453-4057qib7 2159 9 3fx 3fx NNS cord-005453-4057qib7 2159 10 ) ) -RRB- cord-005453-4057qib7 2159 11 than than IN cord-005453-4057qib7 2159 12 fludarabine fludarabine NNP cord-005453-4057qib7 2159 13 + + CC cord-005453-4057qib7 2159 14 endoxan endoxan NN cord-005453-4057qib7 2159 15 for for IN cord-005453-4057qib7 2159 16 patients patient NNS cord-005453-4057qib7 2159 17 with with IN cord-005453-4057qib7 2159 18 HD HD NNP cord-005453-4057qib7 2159 19 ( ( -LRB- cord-005453-4057qib7 2159 20 4 4 CD cord-005453-4057qib7 2159 21 pts pts CD cord-005453-4057qib7 2159 22 ) ) -RRB- cord-005453-4057qib7 2159 23 . . . cord-005453-4057qib7 2160 1 TMI TMI NNP cord-005453-4057qib7 2160 2 ( ( -LRB- cord-005453-4057qib7 2160 3 4Gy 4gy JJ cord-005453-4057qib7 2160 4 x x SYM cord-005453-4057qib7 2160 5 3fx 3fx NNS cord-005453-4057qib7 2160 6 ) ) -RRB- cord-005453-4057qib7 2160 7 + + CC cord-005453-4057qib7 2160 8 fludarabine fludarabine NN cord-005453-4057qib7 2160 9 + + CC cord-005453-4057qib7 2160 10 melphalan melphalan NN cord-005453-4057qib7 2160 11 for for IN cord-005453-4057qib7 2160 12 patients patient NNS cord-005453-4057qib7 2160 13 with with IN cord-005453-4057qib7 2160 14 MM MM NNP cord-005453-4057qib7 2160 15 ( ( -LRB- cord-005453-4057qib7 2160 16 4 4 CD cord-005453-4057qib7 2160 17 pts pts CD cord-005453-4057qib7 2160 18 ) ) -RRB- cord-005453-4057qib7 2160 19 . . . cord-005453-4057qib7 2161 1 TMI TMI NNP cord-005453-4057qib7 2161 2 ( ( -LRB- cord-005453-4057qib7 2161 3 4Gy 4gy NN cord-005453-4057qib7 2161 4 x x SYM cord-005453-4057qib7 2161 5 2 2 CD cord-005453-4057qib7 2161 6 fx fx NNP cord-005453-4057qib7 2161 7 ) ) -RRB- cord-005453-4057qib7 2161 8 + + SYM cord-005453-4057qib7 2161 9 thiotepa thiotepa JJ cord-005453-4057qib7 2161 10 + + CC cord-005453-4057qib7 2161 11 fludarabine fludarabine NN cord-005453-4057qib7 2161 12 + + CC cord-005453-4057qib7 2161 13 busulfan busulfan NN cord-005453-4057qib7 2161 14 for for IN cord-005453-4057qib7 2161 15 advanced advanced JJ cord-005453-4057qib7 2161 16 LAM LAM NNP cord-005453-4057qib7 2161 17 patients patient NNS cord-005453-4057qib7 2161 18 ( ( -LRB- cord-005453-4057qib7 2161 19 4 4 CD cord-005453-4057qib7 2161 20 pts pts CD cord-005453-4057qib7 2161 21 ) ) -RRB- cord-005453-4057qib7 2161 22 . . . cord-005453-4057qib7 2162 1 TMI TMI NNP cord-005453-4057qib7 2162 2 as as IN cord-005453-4057qib7 2162 3 the the DT cord-005453-4057qib7 2162 4 boost boost NN cord-005453-4057qib7 2162 5 ( ( -LRB- cord-005453-4057qib7 2162 6 2 2 CD cord-005453-4057qib7 2162 7 - - HYPH cord-005453-4057qib7 2162 8 3Gy 3gy NN cord-005453-4057qib7 2162 9 ) ) -RRB- cord-005453-4057qib7 2163 1 after after IN cord-005453-4057qib7 2163 2 conventional conventional JJ cord-005453-4057qib7 2163 3 TBI TBI NNP cord-005453-4057qib7 2163 4 was be VBD cord-005453-4057qib7 2163 5 ( ( -LRB- cord-005453-4057qib7 2163 6 12 12 CD cord-005453-4057qib7 2163 7 Gy Gy NNP cord-005453-4057qib7 2163 8 in in IN cord-005453-4057qib7 2163 9 6 6 CD cord-005453-4057qib7 2163 10 bi bi JJ cord-005453-4057qib7 2163 11 - - HYPH cord-005453-4057qib7 2163 12 fractionated fractionate VBN cord-005453-4057qib7 2163 13 doses dose NNS cord-005453-4057qib7 2163 14 ) ) -RRB- cord-005453-4057qib7 2163 15 by by IN cord-005453-4057qib7 2163 16 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 2163 17 ( ( -LRB- cord-005453-4057qib7 2163 18 18 18 CD cord-005453-4057qib7 2163 19 pts pt NNS cord-005453-4057qib7 2163 20 ) ) -RRB- cord-005453-4057qib7 2163 21 . . . cord-005453-4057qib7 2164 1 Autologous autologous JJ cord-005453-4057qib7 2164 2 preparation preparation NN cord-005453-4057qib7 2164 3 to to IN cord-005453-4057qib7 2164 4 SCT SCT NNP cord-005453-4057qib7 2164 5 consisted consist VBD cord-005453-4057qib7 2164 6 of of IN cord-005453-4057qib7 2164 7 TLI TLI NNP cord-005453-4057qib7 2164 8 ( ( -LRB- cord-005453-4057qib7 2164 9 4Gyx 4gyx CD cord-005453-4057qib7 2164 10 3fx 3fx NNS cord-005453-4057qib7 2164 11 ) ) -RRB- cord-005453-4057qib7 2164 12 followed follow VBN cord-005453-4057qib7 2164 13 by by IN cord-005453-4057qib7 2164 14 high high JJ cord-005453-4057qib7 2164 15 - - HYPH cord-005453-4057qib7 2164 16 dose dose NN cord-005453-4057qib7 2164 17 bendamustine bendamustine NN cord-005453-4057qib7 2164 18 and and CC cord-005453-4057qib7 2164 19 melphalan melphalan NNP cord-005453-4057qib7 2164 20 for for IN cord-005453-4057qib7 2164 21 patients patient NNS cord-005453-4057qib7 2164 22 older old JJR cord-005453-4057qib7 2164 23 than than IN cord-005453-4057qib7 2164 24 40 40 CD cord-005453-4057qib7 2164 25 years year NNS cord-005453-4057qib7 2164 26 and and CC cord-005453-4057qib7 2164 27 conventional conventional JJ cord-005453-4057qib7 2164 28 FEAM FEAM NNP cord-005453-4057qib7 2164 29 ( ( -LRB- cord-005453-4057qib7 2164 30 Fotemustine Fotemustine NNP cord-005453-4057qib7 2164 31 , , , cord-005453-4057qib7 2164 32 Etoposide Etoposide NNP cord-005453-4057qib7 2164 33 , , , cord-005453-4057qib7 2164 34 Cytarabine Cytarabine NNP cord-005453-4057qib7 2164 35 , , , cord-005453-4057qib7 2164 36 and and CC cord-005453-4057qib7 2164 37 Melphalan Melphalan NNP cord-005453-4057qib7 2164 38 ) ) -RRB- cord-005453-4057qib7 2164 39 for for IN cord-005453-4057qib7 2164 40 younger young JJR cord-005453-4057qib7 2164 41 patients patient NNS cord-005453-4057qib7 2164 42 , , , cord-005453-4057qib7 2164 43 in in IN cord-005453-4057qib7 2164 44 HD HD NNP cord-005453-4057qib7 2164 45 e e NN cord-005453-4057qib7 2164 46 NHL NHL NNP cord-005453-4057qib7 2164 47 ( ( -LRB- cord-005453-4057qib7 2164 48 20 20 CD cord-005453-4057qib7 2164 49 pts pt NNS cord-005453-4057qib7 2164 50 ) ) -RRB- cord-005453-4057qib7 2164 51 . . . cord-005453-4057qib7 2165 1 While while IN cord-005453-4057qib7 2165 2 TMI TMI NNP cord-005453-4057qib7 2165 3 ( ( -LRB- cord-005453-4057qib7 2165 4 4Gy 4gy NN cord-005453-4057qib7 2165 5 x x SYM cord-005453-4057qib7 2165 6 3 3 CD cord-005453-4057qib7 2165 7 fx fx NNP cord-005453-4057qib7 2165 8 ) ) -RRB- cord-005453-4057qib7 2165 9 plus plus CC cord-005453-4057qib7 2165 10 melphalan melphalan NNP cord-005453-4057qib7 2165 11 was be VBD cord-005453-4057qib7 2165 12 delivered deliver VBN cord-005453-4057qib7 2165 13 for for IN cord-005453-4057qib7 2165 14 autologous autologous JJ cord-005453-4057qib7 2165 15 SCT SCT NNP cord-005453-4057qib7 2165 16 in in IN cord-005453-4057qib7 2165 17 MM MM NNP cord-005453-4057qib7 2165 18 and and CC cord-005453-4057qib7 2165 19 LAM LAM NNP cord-005453-4057qib7 2165 20 ( ( -LRB- cord-005453-4057qib7 2165 21 12 12 CD cord-005453-4057qib7 2165 22 pts pt NNS cord-005453-4057qib7 2165 23 ) ) -RRB- cord-005453-4057qib7 2165 24 . . . cord-005453-4057qib7 2166 1 No no DT cord-005453-4057qib7 2166 2 unexpected unexpected JJ cord-005453-4057qib7 2166 3 acute acute JJ cord-005453-4057qib7 2166 4 toxicity toxicity NN cord-005453-4057qib7 2166 5 was be VBD cord-005453-4057qib7 2166 6 found find VBN cord-005453-4057qib7 2166 7 . . . cord-005453-4057qib7 2167 1 In in IN cord-005453-4057qib7 2167 2 the the DT cord-005453-4057qib7 2167 3 allogenic allogenic NN cord-005453-4057qib7 2167 4 setting setting NN cord-005453-4057qib7 2167 5 , , , cord-005453-4057qib7 2167 6 all all PDT cord-005453-4057qib7 2167 7 the the DT cord-005453-4057qib7 2167 8 patients patient NNS cord-005453-4057qib7 2167 9 ' ' POS cord-005453-4057qib7 2167 10 engraftment engraftment NN cord-005453-4057qib7 2167 11 was be VBD cord-005453-4057qib7 2167 12 achieved achieve VBN cord-005453-4057qib7 2167 13 in in IN cord-005453-4057qib7 2167 14 all all DT cord-005453-4057qib7 2167 15 patients patient NNS cord-005453-4057qib7 2167 16 . . . cord-005453-4057qib7 2168 1 No no DT cord-005453-4057qib7 2168 2 acute acute JJ cord-005453-4057qib7 2168 3 graft graft NN cord-005453-4057qib7 2168 4 versus versus IN cord-005453-4057qib7 2168 5 host host NN cord-005453-4057qib7 2168 6 disease disease NN cord-005453-4057qib7 2168 7 increasing increase VBG cord-005453-4057qib7 2168 8 was be VBD cord-005453-4057qib7 2168 9 detected detect VBN cord-005453-4057qib7 2168 10 . . . cord-005453-4057qib7 2169 1 Within within IN cord-005453-4057qib7 2169 2 the the DT cord-005453-4057qib7 2169 3 autologous autologous JJ cord-005453-4057qib7 2169 4 setting setting NN cord-005453-4057qib7 2169 5 , , , cord-005453-4057qib7 2169 6 only only RB cord-005453-4057qib7 2169 7 33 33 CD cord-005453-4057qib7 2169 8 % % NN cord-005453-4057qib7 2169 9 developed develop VBN cord-005453-4057qib7 2169 10 grade grade NN cord-005453-4057qib7 2169 11 3/4 3/4 CD cord-005453-4057qib7 2169 12 mucositis mucositis NNP cord-005453-4057qib7 2169 13 . . . cord-005453-4057qib7 2170 1 None none NN cord-005453-4057qib7 2170 2 experienced experience VBD cord-005453-4057qib7 2170 3 grade grade NN cord-005453-4057qib7 2170 4 3/4 3/4 CD cord-005453-4057qib7 2170 5 extra extra JJ cord-005453-4057qib7 2170 6 - - HYPH cord-005453-4057qib7 2170 7 hematological hematological JJ cord-005453-4057qib7 2170 8 toxicity toxicity NN cord-005453-4057qib7 2170 9 . . . cord-005453-4057qib7 2171 1 Outcomes outcome NNS cord-005453-4057qib7 2171 2 of of IN cord-005453-4057qib7 2171 3 the the DT cord-005453-4057qib7 2171 4 specific specific JJ cord-005453-4057qib7 2171 5 disease disease NN cord-005453-4057qib7 2171 6 will will MD cord-005453-4057qib7 2171 7 be be VB cord-005453-4057qib7 2171 8 reported report VBN cord-005453-4057qib7 2171 9 . . . cord-005453-4057qib7 2172 1 Conclusions conclusion NNS cord-005453-4057qib7 2172 2 : : : cord-005453-4057qib7 2173 1 The the DT cord-005453-4057qib7 2173 2 current current JJ cord-005453-4057qib7 2173 3 report report NN cord-005453-4057qib7 2173 4 describes describe VBZ cord-005453-4057qib7 2173 5 the the DT cord-005453-4057qib7 2173 6 clinical clinical JJ cord-005453-4057qib7 2173 7 feasibility feasibility NN cord-005453-4057qib7 2173 8 of of IN cord-005453-4057qib7 2173 9 using use VBG cord-005453-4057qib7 2173 10 HT HT NNP cord-005453-4057qib7 2173 11 to to TO cord-005453-4057qib7 2173 12 deliver deliver VB cord-005453-4057qib7 2173 13 TMI TMI NNP cord-005453-4057qib7 2173 14 or or CC cord-005453-4057qib7 2173 15 TLI TLI NNP cord-005453-4057qib7 2173 16 in in IN cord-005453-4057qib7 2173 17 the the DT cord-005453-4057qib7 2173 18 setting setting NN cord-005453-4057qib7 2173 19 of of IN cord-005453-4057qib7 2173 20 autologous autologous JJ cord-005453-4057qib7 2173 21 transplantation transplantation NN cord-005453-4057qib7 2173 22 or or CC cord-005453-4057qib7 2173 23 during during IN cord-005453-4057qib7 2173 24 allogenic allogenic JJ cord-005453-4057qib7 2173 25 stem stem NN cord-005453-4057qib7 2173 26 cell cell NN cord-005453-4057qib7 2173 27 conditioning conditioning NN cord-005453-4057qib7 2173 28 regimen regimen NN cord-005453-4057qib7 2173 29 , , , cord-005453-4057qib7 2173 30 to to TO cord-005453-4057qib7 2173 31 allow allow VB cord-005453-4057qib7 2173 32 all all DT cord-005453-4057qib7 2173 33 patients patient NNS cord-005453-4057qib7 2173 34 ( ( -LRB- cord-005453-4057qib7 2173 35 old old JJ cord-005453-4057qib7 2173 36 , , , cord-005453-4057qib7 2173 37 fragile fragile JJ cord-005453-4057qib7 2173 38 or or CC cord-005453-4057qib7 2173 39 with with IN cord-005453-4057qib7 2173 40 high high JJ cord-005453-4057qib7 2173 41 tumor tumor NN cord-005453-4057qib7 2173 42 burden burden NN cord-005453-4057qib7 2173 43 ) ) -RRB- cord-005453-4057qib7 2173 44 to to TO cord-005453-4057qib7 2173 45 achieve achieve VB cord-005453-4057qib7 2173 46 an an DT cord-005453-4057qib7 2173 47 ablative ablative JJ cord-005453-4057qib7 2173 48 regimen regimen NN cord-005453-4057qib7 2173 49 before before IN cord-005453-4057qib7 2173 50 SCT SCT NNP cord-005453-4057qib7 2173 51 . . . cord-005453-4057qib7 2174 1 To to IN cord-005453-4057qib7 2174 2 our -PRON- PRP$ cord-005453-4057qib7 2174 3 knowledge knowledge NN cord-005453-4057qib7 2174 4 , , , cord-005453-4057qib7 2174 5 this this DT cord-005453-4057qib7 2174 6 single single JJ cord-005453-4057qib7 2174 7 institution institution NN cord-005453-4057qib7 2174 8 experience experience NN cord-005453-4057qib7 2174 9 describes describe VBZ cord-005453-4057qib7 2174 10 data datum NNS cord-005453-4057qib7 2174 11 from from IN cord-005453-4057qib7 2174 12 one one CD cord-005453-4057qib7 2174 13 of of IN cord-005453-4057qib7 2174 14 the the DT cord-005453-4057qib7 2174 15 largest large JJS cord-005453-4057qib7 2174 16 cohort cohort NN cord-005453-4057qib7 2174 17 of of IN cord-005453-4057qib7 2174 18 patients patient NNS cord-005453-4057qib7 2174 19 treated treat VBN cord-005453-4057qib7 2174 20 in in IN cord-005453-4057qib7 2174 21 Europe Europe NNP cord-005453-4057qib7 2174 22 since since IN cord-005453-4057qib7 2174 23 the the DT cord-005453-4057qib7 2174 24 development development NN cord-005453-4057qib7 2174 25 of of IN cord-005453-4057qib7 2174 26 this this DT cord-005453-4057qib7 2174 27 irradiation irradiation NN cord-005453-4057qib7 2174 28 techniques technique NNS cord-005453-4057qib7 2174 29 . . . cord-005453-4057qib7 2175 1 Disclosure Disclosure NNP cord-005453-4057qib7 2175 2 Induction Induction NNP cord-005453-4057qib7 2175 3 therapy therapy NN cord-005453-4057qib7 2175 4 in in IN cord-005453-4057qib7 2175 5 both both DT cord-005453-4057qib7 2175 6 groups group NNS cord-005453-4057qib7 2175 7 of of IN cord-005453-4057qib7 2175 8 patients patient NNS cord-005453-4057qib7 2175 9 was be VBD cord-005453-4057qib7 2175 10 based base VBN cord-005453-4057qib7 2175 11 in in IN cord-005453-4057qib7 2175 12 polychemotherapy polychemotherapy NNP cord-005453-4057qib7 2175 13 without without IN cord-005453-4057qib7 2175 14 the the DT cord-005453-4057qib7 2175 15 use use NN cord-005453-4057qib7 2175 16 of of IN cord-005453-4057qib7 2175 17 new new JJ cord-005453-4057qib7 2175 18 drugs drug NNS cord-005453-4057qib7 2175 19 . . . cord-005453-4057qib7 2176 1 Case case NN cord-005453-4057qib7 2176 2 matching matching NN cord-005453-4057qib7 2176 3 was be VBD cord-005453-4057qib7 2176 4 performed perform VBN cord-005453-4057qib7 2176 5 according accord VBG cord-005453-4057qib7 2176 6 to to IN cord-005453-4057qib7 2176 7 age age NN cord-005453-4057qib7 2176 8 , , , cord-005453-4057qib7 2176 9 clinical clinical JJ cord-005453-4057qib7 2176 10 stage stage NN cord-005453-4057qib7 2176 11 at at IN cord-005453-4057qib7 2176 12 diagnosis diagnosis NN cord-005453-4057qib7 2176 13 , , , cord-005453-4057qib7 2176 14 and and CC cord-005453-4057qib7 2176 15 response response NN cord-005453-4057qib7 2176 16 to to IN cord-005453-4057qib7 2176 17 induction induction NN cord-005453-4057qib7 2176 18 therapy therapy NN cord-005453-4057qib7 2176 19 . . . cord-005453-4057qib7 2177 1 Conditioning conditioning NN cord-005453-4057qib7 2177 2 regimen regimen NN cord-005453-4057qib7 2177 3 consisted consist VBD cord-005453-4057qib7 2177 4 of of IN cord-005453-4057qib7 2177 5 iv iv NNP cord-005453-4057qib7 2177 6 BU BU NNP cord-005453-4057qib7 2177 7 at at IN cord-005453-4057qib7 2177 8 a a DT cord-005453-4057qib7 2177 9 dose dose NN cord-005453-4057qib7 2177 10 of of IN cord-005453-4057qib7 2177 11 3.2 3.2 CD cord-005453-4057qib7 2177 12 mg/ mg/ NN cord-005453-4057qib7 2177 13 kg kg NNP cord-005453-4057qib7 2177 14 once once RB cord-005453-4057qib7 2177 15 a a DT cord-005453-4057qib7 2177 16 day day NN cord-005453-4057qib7 2177 17 on on IN cord-005453-4057qib7 2177 18 days day NNS cord-005453-4057qib7 2177 19 -5 -5 JJ cord-005453-4057qib7 2177 20 to to IN cord-005453-4057qib7 2177 21 -3 -3 NNP cord-005453-4057qib7 2177 22 followed follow VBN cord-005453-4057qib7 2177 23 by by IN cord-005453-4057qib7 2177 24 MEL MEL NNP cord-005453-4057qib7 2177 25 at at IN cord-005453-4057qib7 2177 26 a a DT cord-005453-4057qib7 2177 27 dose dose NN cord-005453-4057qib7 2177 28 of of IN cord-005453-4057qib7 2177 29 -140 -140 NN cord-005453-4057qib7 2178 1 mg mg NNP cord-005453-4057qib7 2178 2 / / SYM cord-005453-4057qib7 2178 3 m m NNP cord-005453-4057qib7 2178 4 2 2 CD cord-005453-4057qib7 2178 5 on on IN cord-005453-4057qib7 2178 6 day day NN cord-005453-4057qib7 2178 7 -2 -2 CD cord-005453-4057qib7 2179 1 in in IN cord-005453-4057qib7 2179 2 the the DT cord-005453-4057qib7 2179 3 BUMEL BUMEL NNP cord-005453-4057qib7 2179 4 group group NN cord-005453-4057qib7 2179 5 versus versus IN cord-005453-4057qib7 2179 6 MEL200 MEL200 NNP cord-005453-4057qib7 2179 7 in in IN cord-005453-4057qib7 2179 8 the the DT cord-005453-4057qib7 2179 9 control control NN cord-005453-4057qib7 2179 10 group group NN cord-005453-4057qib7 2179 11 . . . cord-005453-4057qib7 2180 1 Maintenance maintenance NN cord-005453-4057qib7 2180 2 therapy therapy NN cord-005453-4057qib7 2180 3 after after IN cord-005453-4057qib7 2180 4 transplant transplant NN cord-005453-4057qib7 2180 5 consisted consist VBD cord-005453-4057qib7 2180 6 of of IN cord-005453-4057qib7 2180 7 interferon interferon NN cord-005453-4057qib7 2180 8 and and CC cord-005453-4057qib7 2180 9 steroids steroid NNS cord-005453-4057qib7 2180 10 in in IN cord-005453-4057qib7 2180 11 the the DT cord-005453-4057qib7 2180 12 majority majority NN cord-005453-4057qib7 2180 13 of of IN cord-005453-4057qib7 2180 14 patients patient NNS cord-005453-4057qib7 2180 15 . . . cord-005453-4057qib7 2181 1 Results result NNS cord-005453-4057qib7 2181 2 : : : cord-005453-4057qib7 2182 1 The the DT cord-005453-4057qib7 2182 2 cut cut VB cord-005453-4057qib7 2182 3 - - HYPH cord-005453-4057qib7 2182 4 off off RP cord-005453-4057qib7 2182 5 date date NN cord-005453-4057qib7 2182 6 for for IN cord-005453-4057qib7 2182 7 this this DT cord-005453-4057qib7 2182 8 update update NN cord-005453-4057qib7 2182 9 was be VBD cord-005453-4057qib7 2182 10 June June NNP cord-005453-4057qib7 2182 11 30 30 CD cord-005453-4057qib7 2182 12 , , , cord-005453-4057qib7 2182 13 2018 2018 CD cord-005453-4057qib7 2182 14 . . . cord-005453-4057qib7 2183 1 After after IN cord-005453-4057qib7 2183 2 a a DT cord-005453-4057qib7 2183 3 median median JJ cord-005453-4057qib7 2183 4 follow follow NN cord-005453-4057qib7 2183 5 - - HYPH cord-005453-4057qib7 2183 6 up up NN cord-005453-4057qib7 2183 7 of of IN cord-005453-4057qib7 2183 8 56 56 CD cord-005453-4057qib7 2183 9 and and CC cord-005453-4057qib7 2183 10 63 63 CD cord-005453-4057qib7 2183 11 months month NNS cord-005453-4057qib7 2183 12 in in IN cord-005453-4057qib7 2183 13 the the DT cord-005453-4057qib7 2183 14 BUMEL BUMEL NNP cord-005453-4057qib7 2183 15 and and CC cord-005453-4057qib7 2183 16 MEL200 MEL200 NNP cord-005453-4057qib7 2183 17 groups group NNS cord-005453-4057qib7 2183 18 respectively respectively RB cord-005453-4057qib7 2183 19 , , , cord-005453-4057qib7 2183 20 35 35 CD cord-005453-4057qib7 2183 21 patients patient NNS cord-005453-4057qib7 2183 22 had have VBD cord-005453-4057qib7 2183 23 relapsed relapse VBN cord-005453-4057qib7 2183 24 in in IN cord-005453-4057qib7 2183 25 the the DT cord-005453-4057qib7 2183 26 BUMEL BUMEL NNP cord-005453-4057qib7 2183 27 group group NN cord-005453-4057qib7 2183 28 and and CC cord-005453-4057qib7 2183 29 82 82 CD cord-005453-4057qib7 2183 30 patients patient NNS cord-005453-4057qib7 2183 31 in in IN cord-005453-4057qib7 2183 32 the the DT cord-005453-4057qib7 2183 33 control control NN cord-005453-4057qib7 2183 34 group group NN cord-005453-4057qib7 2183 35 . . . cord-005453-4057qib7 2184 1 Median median JJ cord-005453-4057qib7 2184 2 PFS PFS NNP cord-005453-4057qib7 2184 3 was be VBD cord-005453-4057qib7 2184 4 33 33 CD cord-005453-4057qib7 2185 1 ( ( -LRB- cord-005453-4057qib7 2185 2 95 95 CD cord-005453-4057qib7 2185 3 % % NN cord-005453-4057qib7 2185 4 CI CI NNP cord-005453-4057qib7 2185 5 , , , cord-005453-4057qib7 2185 6 25.4 25.4 CD cord-005453-4057qib7 2185 7 - - SYM cord-005453-4057qib7 2185 8 48.3 48.3 CD cord-005453-4057qib7 2185 9 ) ) -RRB- cord-005453-4057qib7 2185 10 months month NNS cord-005453-4057qib7 2185 11 in in IN cord-005453-4057qib7 2185 12 the the DT cord-005453-4057qib7 2185 13 BUMEL BUMEL NNP cord-005453-4057qib7 2185 14 and and CC cord-005453-4057qib7 2185 15 24 24 CD cord-005453-4057qib7 2185 16 ( ( -LRB- cord-005453-4057qib7 2185 17 95 95 CD cord-005453-4057qib7 2185 18 % % NN cord-005453-4057qib7 2185 19 CI CI NNP cord-005453-4057qib7 2185 20 , , , cord-005453-4057qib7 2185 21 20.1 20.1 CD cord-005453-4057qib7 2185 22 - - HYPH cord-005453-4057qib7 2185 23 32.7 32.7 CD cord-005453-4057qib7 2185 24 ) ) -RRB- cord-005453-4057qib7 2185 25 months month NNS cord-005453-4057qib7 2185 26 in in IN cord-005453-4057qib7 2185 27 the the DT cord-005453-4057qib7 2185 28 MEL200 MEL200 NNP cord-005453-4057qib7 2185 29 group group NN cord-005453-4057qib7 2185 30 ( ( -LRB- cord-005453-4057qib7 2185 31 P p NN cord-005453-4057qib7 2185 32 = = SYM cord-005453-4057qib7 2185 33 0.04 0.04 CD cord-005453-4057qib7 2185 34 ) ) -RRB- cord-005453-4057qib7 2186 1 ( ( -LRB- cord-005453-4057qib7 2186 2 Figure figure NN cord-005453-4057qib7 2186 3 1 1 CD cord-005453-4057qib7 2186 4 ) ) -RRB- cord-005453-4057qib7 2186 5 . . . cord-005453-4057qib7 2187 1 In in IN cord-005453-4057qib7 2187 2 this this DT cord-005453-4057qib7 2187 3 update update NN cord-005453-4057qib7 2187 4 , , , cord-005453-4057qib7 2187 5 12 12 CD cord-005453-4057qib7 2187 6 patients patient NNS cord-005453-4057qib7 2187 7 in in IN cord-005453-4057qib7 2187 8 the the DT cord-005453-4057qib7 2187 9 BUMEL BUMEL NNP cord-005453-4057qib7 2187 10 group group NN cord-005453-4057qib7 2187 11 are be VBP cord-005453-4057qib7 2187 12 in in IN cord-005453-4057qib7 2187 13 maintained maintain VBN cord-005453-4057qib7 2187 14 response response NN cord-005453-4057qib7 2187 15 and and CC cord-005453-4057qib7 2187 16 7 7 CD cord-005453-4057qib7 2187 17 of of IN cord-005453-4057qib7 2187 18 them -PRON- PRP cord-005453-4057qib7 2187 19 are be VBP cord-005453-4057qib7 2187 20 in in IN cord-005453-4057qib7 2187 21 continuous continuous JJ cord-005453-4057qib7 2187 22 CR cr NN cord-005453-4057qib7 2187 23 ( ( -LRB- cord-005453-4057qib7 2187 24 two two CD cord-005453-4057qib7 2187 25 with with IN cord-005453-4057qib7 2187 26 negative negative JJ cord-005453-4057qib7 2187 27 status status NN cord-005453-4057qib7 2187 28 for for IN cord-005453-4057qib7 2187 29 minimal minimal JJ cord-005453-4057qib7 2187 30 residual residual JJ cord-005453-4057qib7 2187 31 disease disease NN cord-005453-4057qib7 2187 32 ) ) -RRB- cord-005453-4057qib7 2187 33 between between IN cord-005453-4057qib7 2187 34 9 9 CD cord-005453-4057qib7 2187 35 and and CC cord-005453-4057qib7 2187 36 12 12 CD cord-005453-4057qib7 2187 37 years year NNS cord-005453-4057qib7 2187 38 after after IN cord-005453-4057qib7 2187 39 transplantation transplantation NN cord-005453-4057qib7 2187 40 . . . cord-005453-4057qib7 2188 1 Ten ten CD cord-005453-4057qib7 2188 2 - - HYPH cord-005453-4057qib7 2188 3 year year NN cord-005453-4057qib7 2188 4 OS OS NNP cord-005453-4057qib7 2188 5 was be VBD cord-005453-4057qib7 2188 6 not not RB cord-005453-4057qib7 2188 7 significantly significantly RB cord-005453-4057qib7 2188 8 different different JJ cord-005453-4057qib7 2188 9 between between IN cord-005453-4057qib7 2188 10 both both DT cord-005453-4057qib7 2188 11 groups group NNS cord-005453-4057qib7 2188 12 , , , cord-005453-4057qib7 2188 13 being be VBG cord-005453-4057qib7 2188 14 41 41 CD cord-005453-4057qib7 2189 1 ( ( -LRB- cord-005453-4057qib7 2189 2 95 95 CD cord-005453-4057qib7 2189 3 % % NN cord-005453-4057qib7 2189 4 CI CI NNP cord-005453-4057qib7 2189 5 30 30 CD cord-005453-4057qib7 2189 6 - - SYM cord-005453-4057qib7 2189 7 58 58 CD cord-005453-4057qib7 2189 8 ) ) -RRB- cord-005453-4057qib7 2189 9 months month NNS cord-005453-4057qib7 2189 10 in in IN cord-005453-4057qib7 2189 11 the the DT cord-005453-4057qib7 2189 12 BUMEL BUMEL NNP cord-005453-4057qib7 2189 13 and and CC cord-005453-4057qib7 2189 14 29 29 CD cord-005453-4057qib7 2190 1 ( ( -LRB- cord-005453-4057qib7 2190 2 95 95 CD cord-005453-4057qib7 2190 3 % % NN cord-005453-4057qib7 2190 4 CI CI NNP cord-005453-4057qib7 2190 5 18 18 CD cord-005453-4057qib7 2190 6 - - SYM cord-005453-4057qib7 2190 7 47 47 CD cord-005453-4057qib7 2190 8 ) ) -RRB- cord-005453-4057qib7 2190 9 months month NNS cord-005453-4057qib7 2190 10 in in IN cord-005453-4057qib7 2190 11 the the DT cord-005453-4057qib7 2190 12 control control NN cord-005453-4057qib7 2190 13 group group NN cord-005453-4057qib7 2190 14 . . . cord-005453-4057qib7 2191 1 Transplant transplant NN cord-005453-4057qib7 2191 2 - - HYPH cord-005453-4057qib7 2191 3 related relate VBN cord-005453-4057qib7 2191 4 mortality mortality NN cord-005453-4057qib7 2191 5 was be VBD cord-005453-4057qib7 2191 6 similar similar JJ cord-005453-4057qib7 2191 7 in in IN cord-005453-4057qib7 2191 8 both both DT cord-005453-4057qib7 2191 9 groups group NNS cord-005453-4057qib7 2191 10 of of IN cord-005453-4057qib7 2191 11 patients patient NNS cord-005453-4057qib7 2191 12 ( ( -LRB- cord-005453-4057qib7 2191 13 4 4 CD cord-005453-4057qib7 2191 14 % % NN cord-005453-4057qib7 2191 15 in in IN cord-005453-4057qib7 2191 16 the the DT cord-005453-4057qib7 2191 17 BUMEL BUMEL NNP cord-005453-4057qib7 2191 18 and and CC cord-005453-4057qib7 2191 19 2 2 CD cord-005453-4057qib7 2191 20 % % NN cord-005453-4057qib7 2191 21 in in IN cord-005453-4057qib7 2191 22 the the DT cord-005453-4057qib7 2191 23 MEL200 MEL200 NNP cord-005453-4057qib7 2191 24 group group NN cord-005453-4057qib7 2191 25 ) ) -RRB- cord-005453-4057qib7 2191 26 . . . cord-005453-4057qib7 2192 1 Regarding regard VBG cord-005453-4057qib7 2192 2 toxicity toxicity NN cord-005453-4057qib7 2192 3 , , , cord-005453-4057qib7 2192 4 BUMEL BUMEL NNP cord-005453-4057qib7 2192 5 was be VBD cord-005453-4057qib7 2192 6 associated associate VBN cord-005453-4057qib7 2192 7 with with IN cord-005453-4057qib7 2192 8 a a DT cord-005453-4057qib7 2192 9 higher high JJR cord-005453-4057qib7 2192 10 incidence incidence NN cord-005453-4057qib7 2192 11 of of IN cord-005453-4057qib7 2192 12 mucositis mucositis NN cord-005453-4057qib7 2192 13 and and CC cord-005453-4057qib7 2192 14 liver liver NN cord-005453-4057qib7 2192 15 toxicity toxicity NN cord-005453-4057qib7 2192 16 than than IN cord-005453-4057qib7 2192 17 the the DT cord-005453-4057qib7 2192 18 melphalan melphalan NN cord-005453-4057qib7 2192 19 - - HYPH cord-005453-4057qib7 2192 20 only only JJ cord-005453-4057qib7 2192 21 approach approach NN cord-005453-4057qib7 2192 22 but but CC cord-005453-4057qib7 2192 23 no no DT cord-005453-4057qib7 2192 24 patient patient NN cord-005453-4057qib7 2192 25 in in IN cord-005453-4057qib7 2192 26 our -PRON- PRP$ cord-005453-4057qib7 2192 27 series series NN cord-005453-4057qib7 2192 28 developed develop VBD cord-005453-4057qib7 2192 29 sinusoidal sinusoidal DT cord-005453-4057qib7 2192 30 occlusive occlusive JJ cord-005453-4057qib7 2192 31 syndrome syndrome NN cord-005453-4057qib7 2192 32 and and CC cord-005453-4057qib7 2192 33 the the DT cord-005453-4057qib7 2192 34 hepatic hepatic JJ cord-005453-4057qib7 2192 35 toxicity toxicity NN cord-005453-4057qib7 2192 36 observed observe VBD cord-005453-4057qib7 2192 37 was be VBD cord-005453-4057qib7 2192 38 only only RB cord-005453-4057qib7 2192 39 grade grade NN cord-005453-4057qib7 2192 40 I I NNP cord-005453-4057qib7 2192 41 / / SYM cord-005453-4057qib7 2192 42 II II NNP cord-005453-4057qib7 2192 43 . . . cord-005453-4057qib7 2193 1 Finally finally RB cord-005453-4057qib7 2193 2 , , , cord-005453-4057qib7 2193 3 no no DT cord-005453-4057qib7 2193 4 long long JJ cord-005453-4057qib7 2193 5 - - HYPH cord-005453-4057qib7 2193 6 term term NN cord-005453-4057qib7 2193 7 side side NN cord-005453-4057qib7 2193 8 effects effect NNS cord-005453-4057qib7 2193 9 have have VBP cord-005453-4057qib7 2193 10 been be VBN cord-005453-4057qib7 2193 11 reported report VBN cord-005453-4057qib7 2193 12 among among IN cord-005453-4057qib7 2193 13 BUMEL BUMEL NNP cord-005453-4057qib7 2193 14 recipients recipient NNS cord-005453-4057qib7 2193 15 . . . cord-005453-4057qib7 2194 1 Conclusions conclusion NNS cord-005453-4057qib7 2194 2 : : : cord-005453-4057qib7 2195 1 This this DT cord-005453-4057qib7 2195 2 long long JJ cord-005453-4057qib7 2195 3 - - HYPH cord-005453-4057qib7 2195 4 term term NN cord-005453-4057qib7 2195 5 follow follow NN cord-005453-4057qib7 2195 6 - - HYPH cord-005453-4057qib7 2195 7 up up RP cord-005453-4057qib7 2195 8 analysis analysis NN cord-005453-4057qib7 2195 9 confirms confirm VBZ cord-005453-4057qib7 2195 10 that that IN cord-005453-4057qib7 2195 11 a a DT cord-005453-4057qib7 2195 12 therapeutic therapeutic JJ cord-005453-4057qib7 2195 13 strategy strategy NN cord-005453-4057qib7 2195 14 including include VBG cord-005453-4057qib7 2195 15 BUMEL BUMEL NNP cord-005453-4057qib7 2195 16 as as IN cord-005453-4057qib7 2195 17 conditioning conditioning NN cord-005453-4057qib7 2195 18 regimen regimen NN cord-005453-4057qib7 2195 19 beforeASCT beforeasct NN cord-005453-4057qib7 2195 20 in in IN cord-005453-4057qib7 2195 21 patients patient NNS cord-005453-4057qib7 2195 22 with with IN cord-005453-4057qib7 2195 23 newly newly RB cord-005453-4057qib7 2195 24 diagnosed diagnose VBN cord-005453-4057qib7 2195 25 MM MM NNP cord-005453-4057qib7 2195 26 is be VBZ cord-005453-4057qib7 2195 27 highly highly RB cord-005453-4057qib7 2195 28 active active JJ cord-005453-4057qib7 2195 29 and and CC cord-005453-4057qib7 2195 30 safe safe JJ cord-005453-4057qib7 2195 31 in in IN cord-005453-4057qib7 2195 32 these these DT cord-005453-4057qib7 2195 33 patients patient NNS cord-005453-4057qib7 2195 34 . . . cord-005453-4057qib7 2196 1 [ [ -LRB- cord-005453-4057qib7 2196 2 [ [ -LRB- cord-005453-4057qib7 2196 3 P113 P113 NNP cord-005453-4057qib7 2196 4 Image Image NNP cord-005453-4057qib7 2196 5 ] ] -RRB- cord-005453-4057qib7 2196 6 1 1 CD cord-005453-4057qib7 2196 7 . . . cord-005453-4057qib7 2197 1 Figure figure NN cord-005453-4057qib7 2197 2 1 1 CD cord-005453-4057qib7 2197 3 . . . cord-005453-4057qib7 2198 1 Progression progression NN cord-005453-4057qib7 2198 2 free free JJ cord-005453-4057qib7 2198 3 survival survival NN cord-005453-4057qib7 2198 4 in in IN cord-005453-4057qib7 2198 5 the the DT cord-005453-4057qib7 2198 6 BUMEL BUMEL NNP cord-005453-4057qib7 2199 1 ( ( -LRB- cord-005453-4057qib7 2199 2 _ _ NN cord-005453-4057qib7 2200 1 _ _ NNP cord-005453-4057qib7 2200 2 _ _ NNP cord-005453-4057qib7 2200 3 _ _ NNP cord-005453-4057qib7 2200 4 ) ) -RRB- cord-005453-4057qib7 2200 5 and and CC cord-005453-4057qib7 2200 6 control control NN cord-005453-4057qib7 2200 7 group group NN cord-005453-4057qib7 2200 8 ( ( -LRB- cord-005453-4057qib7 2200 9 …… …… `` cord-005453-4057qib7 2200 10 Frequency frequency NN cord-005453-4057qib7 2200 11 of of IN cord-005453-4057qib7 2200 12 acute acute JJ cord-005453-4057qib7 2200 13 GvHD GvHD NNP cord-005453-4057qib7 2200 14 _SP cord-005453-4057qib7 2200 15 grade grade NN cord-005453-4057qib7 2200 16 III III NNP cord-005453-4057qib7 2200 17 - - HYPH cord-005453-4057qib7 2200 18 IV IV NNP cord-005453-4057qib7 2201 1 [ [ -LRB- cord-005453-4057qib7 2201 2 CC cc NN cord-005453-4057qib7 2201 3 : : : cord-005453-4057qib7 2201 4 11 11 CD cord-005453-4057qib7 2201 5 % % NN cord-005453-4057qib7 2201 6 ; ; : cord-005453-4057qib7 2201 7 CT CT NNP cord-005453-4057qib7 2201 8 : : : cord-005453-4057qib7 2201 9 17 17 CD cord-005453-4057qib7 2201 10 % % NN cord-005453-4057qib7 2201 11 ; ; : cord-005453-4057qib7 2201 12 TT tt NN cord-005453-4057qib7 2201 13 : : : cord-005453-4057qib7 2201 14 24 24 CD cord-005453-4057qib7 2201 15 % % NN cord-005453-4057qib7 2201 16 , , , cord-005453-4057qib7 2201 17 p=0.057 p=0.057 NNP cord-005453-4057qib7 2201 18 ] ] -RRB- cord-005453-4057qib7 2201 19 , , , cord-005453-4057qib7 2201 20 and and CC cord-005453-4057qib7 2201 21 _SP cord-005453-4057qib7 2201 22 transplant transplant NN cord-005453-4057qib7 2201 23 - - HYPH cord-005453-4057qib7 2201 24 related relate VBN cord-005453-4057qib7 2201 25 mortality mortality NN cord-005453-4057qib7 2201 26 was be VBD cord-005453-4057qib7 2201 27 higher high JJR cord-005453-4057qib7 2201 28 in in IN cord-005453-4057qib7 2201 29 TT TT NNP cord-005453-4057qib7 2201 30 - - HYPH cord-005453-4057qib7 2201 31 carriers carrier NNS cord-005453-4057qib7 2201 32 _SP cord-005453-4057qib7 2201 33 ( ( -LRB- cord-005453-4057qib7 2201 34 CC:26 cc:26 CD cord-005453-4057qib7 2201 35 % % NN cord-005453-4057qib7 2201 36 ; ; : cord-005453-4057qib7 2201 37 CT:28 CT:28 NNP cord-005453-4057qib7 2201 38 % % NN cord-005453-4057qib7 2201 39 ; ; : cord-005453-4057qib7 2201 40 TT:46 tt:46 CD cord-005453-4057qib7 2201 41 % % NN cord-005453-4057qib7 2201 42 , , , cord-005453-4057qib7 2201 43 p=0.02 p=0.02 NNP cord-005453-4057qib7 2201 44 CC&CT CC&CT NNP cord-005453-4057qib7 2201 45 vs vs IN cord-005453-4057qib7 2201 46 TT TT NNP cord-005453-4057qib7 2201 47 ) ) -RRB- cord-005453-4057qib7 2201 48 . . . cord-005453-4057qib7 2202 1 TA TA NNP cord-005453-4057qib7 2202 2 - - HYPH cord-005453-4057qib7 2202 3 TMA TMA NNP cord-005453-4057qib7 2202 4 , , , cord-005453-4057qib7 2202 5 CMV CMV NNP cord-005453-4057qib7 2202 6 infection infection NN cord-005453-4057qib7 2202 7 / / SYM cord-005453-4057qib7 2202 8 reactivation reactivation NN cord-005453-4057qib7 2202 9 and and CC cord-005453-4057qib7 2202 10 cGvHD cgvhd NN cord-005453-4057qib7 2202 11 were be VBD cord-005453-4057qib7 2202 12 also also RB cord-005453-4057qib7 2202 13 not not RB cord-005453-4057qib7 2202 14 different different JJ cord-005453-4057qib7 2202 15 according accord VBG cord-005453-4057qib7 2202 16 to to IN cord-005453-4057qib7 2202 17 donor donor NN cord-005453-4057qib7 2202 18 genotypes genotype NNS cord-005453-4057qib7 2202 19 . . . cord-005453-4057qib7 2203 1 Fungal fungal JJ cord-005453-4057qib7 2203 2 infections infection NNS cord-005453-4057qib7 2203 3 occurred occur VBD cord-005453-4057qib7 2203 4 more more RBR cord-005453-4057qib7 2203 5 frequently frequently RB cord-005453-4057qib7 2203 6 as as IN cord-005453-4057qib7 2203 7 causes cause NNS cord-005453-4057qib7 2203 8 of of IN cord-005453-4057qib7 2203 9 death death NN cord-005453-4057qib7 2203 10 in in IN cord-005453-4057qib7 2203 11 carriers carrier NNS cord-005453-4057qib7 2203 12 ( ( -LRB- cord-005453-4057qib7 2203 13 CC cc NN cord-005453-4057qib7 2203 14 : : : cord-005453-4057qib7 2203 15 9.7 9.7 CD cord-005453-4057qib7 2203 16 % % NN cord-005453-4057qib7 2203 17 vs. vs. IN cord-005453-4057qib7 2203 18 CT CT NNP cord-005453-4057qib7 2203 19 : : : cord-005453-4057qib7 2203 20 38.1 38.1 CD cord-005453-4057qib7 2203 21 % % NN cord-005453-4057qib7 2203 22 vs vs IN cord-005453-4057qib7 2203 23 TT TT NNP cord-005453-4057qib7 2203 24 : : : cord-005453-4057qib7 2203 25 33.3 33.3 CD cord-005453-4057qib7 2203 26 % % NN cord-005453-4057qib7 2203 27 , , , cord-005453-4057qib7 2203 28 p=0.022 p=0.022 NNP cord-005453-4057qib7 2203 29 ) ) -RRB- cord-005453-4057qib7 2203 30 . . . cord-005453-4057qib7 2204 1 Conclusions conclusion NNS cord-005453-4057qib7 2204 2 : : : cord-005453-4057qib7 2205 1 Our -PRON- PRP$ cord-005453-4057qib7 2205 2 results result NNS cord-005453-4057qib7 2205 3 suggest suggest VBP cord-005453-4057qib7 2205 4 that that IN cord-005453-4057qib7 2205 5 donor donor NN cord-005453-4057qib7 2205 6 TGFB1 TGFB1 NNP cord-005453-4057qib7 2205 7 -1347C -1347c CD cord-005453-4057qib7 2206 1 > > XX cord-005453-4057qib7 2207 1 T T NNP cord-005453-4057qib7 2207 2 may may MD cord-005453-4057qib7 2207 3 exert exert VB cord-005453-4057qib7 2207 4 an an DT cord-005453-4057qib7 2207 5 adverse adverse JJ cord-005453-4057qib7 2207 6 influence influence NN cord-005453-4057qib7 2207 7 on on IN cord-005453-4057qib7 2207 8 the the DT cord-005453-4057qib7 2207 9 outcome outcome NN cord-005453-4057qib7 2207 10 of of IN cord-005453-4057qib7 2207 11 myeloablative myeloablative JJ cord-005453-4057qib7 2207 12 conditioning conditioning NN cord-005453-4057qib7 2207 13 . . . cord-005453-4057qib7 2208 1 Our -PRON- PRP$ cord-005453-4057qib7 2208 2 finding finding NN cord-005453-4057qib7 2208 3 might may MD cord-005453-4057qib7 2208 4 be be VB cord-005453-4057qib7 2208 5 explained explain VBN cord-005453-4057qib7 2208 6 by by IN cord-005453-4057qib7 2208 7 the the DT cord-005453-4057qib7 2208 8 combination combination NN cord-005453-4057qib7 2208 9 therapy therapy NN cord-005453-4057qib7 2208 10 of of IN cord-005453-4057qib7 2208 11 calcineurin calcineurin NNP cord-005453-4057qib7 2208 12 and and CC cord-005453-4057qib7 2208 13 mTOR mTOR NNP cord-005453-4057qib7 2208 14 inhibition inhibition NN cord-005453-4057qib7 2208 15 in in IN cord-005453-4057qib7 2208 16 GvHD GvHD NNP cord-005453-4057qib7 2208 17 prophylaxis prophylaxis NN cord-005453-4057qib7 2208 18 in in IN cord-005453-4057qib7 2208 19 myeloablative myeloablative JJ cord-005453-4057qib7 2208 20 conditioning conditioning NN cord-005453-4057qib7 2208 21 . . . cord-005453-4057qib7 2209 1 Disclosure disclosure NN cord-005453-4057qib7 2209 2 : : : cord-005453-4057qib7 2209 3 Nothing nothing NN cord-005453-4057qib7 2209 4 to to TO cord-005453-4057qib7 2209 5 declare declare VB cord-005453-4057qib7 2209 6 . . . cord-005453-4057qib7 2210 1 Treosulfan Treosulfan NNP cord-005453-4057qib7 2210 2 - - HYPH cord-005453-4057qib7 2210 3 based base VBN cord-005453-4057qib7 2210 4 reduced reduced JJ cord-005453-4057qib7 2210 5 intensity intensity NN cord-005453-4057qib7 2210 6 conditioning conditioning NN cord-005453-4057qib7 2210 7 in in IN cord-005453-4057qib7 2210 8 HLA HLA NNP cord-005453-4057qib7 2210 9 - - HYPH cord-005453-4057qib7 2210 10 haploidentical haploidentical JJ cord-005453-4057qib7 2210 11 transplantation transplantation NN cord-005453-4057qib7 2210 12 using use VBG cord-005453-4057qib7 2210 13 PTCY PTCY NNP cord-005453-4057qib7 2210 14 as as IN cord-005453-4057qib7 2210 15 GVHD GVHD NNP cord-005453-4057qib7 2210 16 prophylaxis prophylaxis NN cord-005453-4057qib7 2210 17 in in IN cord-005453-4057qib7 2210 18 high high JJ cord-005453-4057qib7 2210 19 - - HYPH cord-005453-4057qib7 2210 20 risk risk NN cord-005453-4057qib7 2210 21 MDS MDS NNP cord-005453-4057qib7 2210 22 /AML /AML . cord-005453-4057qib7 2210 23 of of IN cord-005453-4057qib7 2210 24 the the DT cord-005453-4057qib7 2210 25 elderly elderly JJ cord-005453-4057qib7 2210 26 Background background NN cord-005453-4057qib7 2210 27 : : : cord-005453-4057qib7 2211 1 Standard standard JJ cord-005453-4057qib7 2211 2 conditioning conditioning NN cord-005453-4057qib7 2211 3 regimens regimen NNS cord-005453-4057qib7 2211 4 prior prior RB cord-005453-4057qib7 2211 5 to to IN cord-005453-4057qib7 2211 6 allogeneic allogeneic JJ cord-005453-4057qib7 2211 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 2211 8 stem stem NN cord-005453-4057qib7 2211 9 cell cell NN cord-005453-4057qib7 2211 10 transplantation transplantation NN cord-005453-4057qib7 2211 11 ( ( -LRB- cord-005453-4057qib7 2211 12 allo allo NN cord-005453-4057qib7 2211 13 - - HYPH cord-005453-4057qib7 2211 14 HSCT HSCT NNP cord-005453-4057qib7 2211 15 ) ) -RRB- cord-005453-4057qib7 2211 16 are be VBP cord-005453-4057qib7 2211 17 often often RB cord-005453-4057qib7 2211 18 associated associate VBN cord-005453-4057qib7 2211 19 with with IN cord-005453-4057qib7 2211 20 a a DT cord-005453-4057qib7 2211 21 considerable considerable JJ cord-005453-4057qib7 2211 22 risk risk NN cord-005453-4057qib7 2211 23 of of IN cord-005453-4057qib7 2211 24 severe severe JJ cord-005453-4057qib7 2211 25 adverse adverse JJ cord-005453-4057qib7 2211 26 events event NNS cord-005453-4057qib7 2211 27 , , , cord-005453-4057qib7 2211 28 especially especially RB cord-005453-4057qib7 2211 29 in in IN cord-005453-4057qib7 2211 30 elderly elderly JJ cord-005453-4057qib7 2211 31 patients patient NNS cord-005453-4057qib7 2211 32 suffering suffer VBG cord-005453-4057qib7 2211 33 from from IN cord-005453-4057qib7 2211 34 high high JJ cord-005453-4057qib7 2211 35 - - HYPH cord-005453-4057qib7 2211 36 risk risk NN cord-005453-4057qib7 2211 37 ( ( -LRB- cord-005453-4057qib7 2211 38 HR hr NN cord-005453-4057qib7 2211 39 ) ) -RRB- cord-005453-4057qib7 2211 40 MDS MDS NNP cord-005453-4057qib7 2211 41 / / SYM cord-005453-4057qib7 2211 42 AML AML NNP cord-005453-4057qib7 2211 43 . . . cord-005453-4057qib7 2212 1 Previous previous JJ cord-005453-4057qib7 2212 2 clinical clinical JJ cord-005453-4057qib7 2212 3 studies study NNS cord-005453-4057qib7 2212 4 have have VBP cord-005453-4057qib7 2212 5 demonstrated demonstrate VBN cord-005453-4057qib7 2212 6 feasibility feasibility NN cord-005453-4057qib7 2212 7 of of IN cord-005453-4057qib7 2212 8 treosulfan treosulfan NNP cord-005453-4057qib7 2212 9 - - HYPH cord-005453-4057qib7 2212 10 based base VBN cord-005453-4057qib7 2212 11 reduced reduce VBN cord-005453-4057qib7 2212 12 - - HYPH cord-005453-4057qib7 2212 13 intensity intensity NN cord-005453-4057qib7 2212 14 conditioning conditioning NN cord-005453-4057qib7 2212 15 ( ( -LRB- cord-005453-4057qib7 2212 16 RIC RIC NNP cord-005453-4057qib7 2212 17 ) ) -RRB- cord-005453-4057qib7 2212 18 by by IN cord-005453-4057qib7 2212 19 stable stable JJ cord-005453-4057qib7 2212 20 engraftment engraftment NN cord-005453-4057qib7 2212 21 , , , cord-005453-4057qib7 2212 22 low low JJ cord-005453-4057qib7 2212 23 non non JJ cord-005453-4057qib7 2212 24 - - JJ cord-005453-4057qib7 2212 25 relapse relapse JJ cord-005453-4057qib7 2212 26 mortality mortality NN cord-005453-4057qib7 2212 27 ( ( -LRB- cord-005453-4057qib7 2212 28 NRM NRM NNP cord-005453-4057qib7 2212 29 ) ) -RRB- cord-005453-4057qib7 2212 30 , , , cord-005453-4057qib7 2212 31 and and CC cord-005453-4057qib7 2212 32 favorable favorable JJ cord-005453-4057qib7 2212 33 survival survival NN cord-005453-4057qib7 2212 34 in in IN cord-005453-4057qib7 2212 35 elderly elderly JJ cord-005453-4057qib7 2212 36 patients patient NNS cord-005453-4057qib7 2212 37 undergoing undergo VBG cord-005453-4057qib7 2212 38 HLA HLA NNP cord-005453-4057qib7 2212 39 - - HYPH cord-005453-4057qib7 2212 40 matched match VBN cord-005453-4057qib7 2212 41 related related JJ cord-005453-4057qib7 2212 42 or or CC cord-005453-4057qib7 2212 43 unrelated unrelated JJ cord-005453-4057qib7 2212 44 allo allo NN cord-005453-4057qib7 2212 45 - - HYPH cord-005453-4057qib7 2212 46 HSCT HSCT NNP cord-005453-4057qib7 2212 47 ( ( -LRB- cord-005453-4057qib7 2212 48 Beelen Beelen NNP cord-005453-4057qib7 2212 49 et et NNP cord-005453-4057qib7 2212 50 al al NNP cord-005453-4057qib7 2212 51 , , , cord-005453-4057qib7 2212 52 ASH ASH NNP cord-005453-4057qib7 2212 53 2017 2017 CD cord-005453-4057qib7 2212 54 # # $ cord-005453-4057qib7 2212 55 0521 0521 CD cord-005453-4057qib7 2212 56 ) ) -RRB- cord-005453-4057qib7 2212 57 . . . cord-005453-4057qib7 2213 1 However however RB cord-005453-4057qib7 2213 2 , , , cord-005453-4057qib7 2213 3 data datum NNS cord-005453-4057qib7 2213 4 for for IN cord-005453-4057qib7 2213 5 treosulfan treosulfan NNP cord-005453-4057qib7 2213 6 - - HYPH cord-005453-4057qib7 2213 7 based base VBN cord-005453-4057qib7 2213 8 conditioning conditioning NN cord-005453-4057qib7 2213 9 in in IN cord-005453-4057qib7 2213 10 the the DT cord-005453-4057qib7 2213 11 T t NN cord-005453-4057qib7 2213 12 - - HYPH cord-005453-4057qib7 2213 13 cell cell NN cord-005453-4057qib7 2213 14 - - HYPH cord-005453-4057qib7 2213 15 replete replete JJ cord-005453-4057qib7 2213 16 HLAhaploidentical HLAhaploidentical NNP cord-005453-4057qib7 2213 17 ( ( -LRB- cord-005453-4057qib7 2213 18 haplo haplo NNP cord-005453-4057qib7 2213 19 - - HYPH cord-005453-4057qib7 2213 20 HSCT HSCT NNP cord-005453-4057qib7 2213 21 ) ) -RRB- cord-005453-4057qib7 2213 22 setting set VBG cord-005453-4057qib7 2213 23 in in IN cord-005453-4057qib7 2213 24 high high JJ cord-005453-4057qib7 2213 25 - - HYPH cord-005453-4057qib7 2213 26 risk risk NN cord-005453-4057qib7 2213 27 AML AML NNP cord-005453-4057qib7 2213 28 / / SYM cord-005453-4057qib7 2213 29 MDS MDS NNP cord-005453-4057qib7 2213 30 patients patient NNS cord-005453-4057qib7 2213 31 are be VBP cord-005453-4057qib7 2213 32 rare rare JJ cord-005453-4057qib7 2213 33 . . . cord-005453-4057qib7 2214 1 Here here RB cord-005453-4057qib7 2214 2 we -PRON- PRP cord-005453-4057qib7 2214 3 report report VBP cord-005453-4057qib7 2214 4 on on IN cord-005453-4057qib7 2214 5 the the DT cord-005453-4057qib7 2214 6 outcome outcome NN cord-005453-4057qib7 2214 7 of of IN cord-005453-4057qib7 2214 8 eleven eleven CD cord-005453-4057qib7 2214 9 patients patient NNS cord-005453-4057qib7 2214 10 treated treat VBN cord-005453-4057qib7 2214 11 with with IN cord-005453-4057qib7 2214 12 a a DT cord-005453-4057qib7 2214 13 treosulfan treosulfan NN cord-005453-4057qib7 2214 14 - - HYPH cord-005453-4057qib7 2214 15 based base VBN cord-005453-4057qib7 2214 16 conditioning conditioning NN cord-005453-4057qib7 2214 17 undergoing undergo VBG cord-005453-4057qib7 2214 18 haplo haplo NNP cord-005453-4057qib7 2214 19 - - HYPH cord-005453-4057qib7 2214 20 HSCT HSCT NNP cord-005453-4057qib7 2214 21 using use VBG cord-005453-4057qib7 2214 22 exclusively exclusively RB cord-005453-4057qib7 2214 23 post post JJ cord-005453-4057qib7 2214 24 - - NN cord-005453-4057qib7 2214 25 transplantation transplantation JJ cord-005453-4057qib7 2214 26 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 2214 27 ( ( -LRB- cord-005453-4057qib7 2214 28 PTCY PTCY NNP cord-005453-4057qib7 2214 29 ) ) -RRB- cord-005453-4057qib7 2214 30 as as IN cord-005453-4057qib7 2214 31 GvHD GvHD NNP cord-005453-4057qib7 2214 32 prophylaxis prophylaxis NN cord-005453-4057qib7 2214 33 . . . cord-005453-4057qib7 2215 1 Methods method NNS cord-005453-4057qib7 2215 2 : : : cord-005453-4057qib7 2215 3 Eleven eleven CD cord-005453-4057qib7 2215 4 patients patient NNS cord-005453-4057qib7 2215 5 with with IN cord-005453-4057qib7 2215 6 high high JJ cord-005453-4057qib7 2215 7 - - HYPH cord-005453-4057qib7 2215 8 risk risk NN cord-005453-4057qib7 2215 9 ( ( -LRB- cord-005453-4057qib7 2215 10 HR HR NNP cord-005453-4057qib7 2215 11 ) ) -RRB- cord-005453-4057qib7 2215 12 AML AML NNP cord-005453-4057qib7 2215 13 ( ( -LRB- cord-005453-4057qib7 2215 14 n=9)/MDS n=9)/MDS NNP cord-005453-4057qib7 2215 15 ( ( -LRB- cord-005453-4057qib7 2215 16 n=2 n=2 NNS cord-005453-4057qib7 2215 17 ) ) -RRB- cord-005453-4057qib7 2215 18 who who WP cord-005453-4057qib7 2215 19 underwent undergo VBD cord-005453-4057qib7 2215 20 haplo haplo NN cord-005453-4057qib7 2215 21 - - HYPH cord-005453-4057qib7 2215 22 HSCT HSCT NNP cord-005453-4057qib7 2215 23 using use VBG cord-005453-4057qib7 2215 24 treosulfan treosulfan NNP cord-005453-4057qib7 2215 25 for for IN cord-005453-4057qib7 2215 26 reduced reduced JJ cord-005453-4057qib7 2215 27 intensity intensity NN cord-005453-4057qib7 2215 28 conditioning conditioning NN cord-005453-4057qib7 2215 29 ( ( -LRB- cord-005453-4057qib7 2215 30 RIC RIC NNP cord-005453-4057qib7 2215 31 ) ) -RRB- cord-005453-4057qib7 2215 32 and and CC cord-005453-4057qib7 2215 33 PTCY PTCY NNP cord-005453-4057qib7 2215 34 as as IN cord-005453-4057qib7 2215 35 GvHD GvHD NNP cord-005453-4057qib7 2215 36 prophylaxis prophylaxis NN cord-005453-4057qib7 2215 37 were be VBD cord-005453-4057qib7 2215 38 retrospectively retrospectively RB cord-005453-4057qib7 2215 39 analyzed analyze VBN cord-005453-4057qib7 2215 40 with with IN cord-005453-4057qib7 2215 41 respect respect NN cord-005453-4057qib7 2215 42 to to IN cord-005453-4057qib7 2215 43 outcome outcome NN cord-005453-4057qib7 2215 44 and and CC cord-005453-4057qib7 2215 45 toxicity toxicity NN cord-005453-4057qib7 2215 46 . . . cord-005453-4057qib7 2216 1 All all DT cord-005453-4057qib7 2216 2 patients patient NNS cord-005453-4057qib7 2216 3 were be VBD cord-005453-4057qib7 2216 4 > > $ cord-005453-4057qib7 2216 5 55 55 CD cord-005453-4057qib7 2216 6 years year NNS cord-005453-4057qib7 2216 7 old old JJ cord-005453-4057qib7 2216 8 and and CC cord-005453-4057qib7 2216 9 transplanted transplant VBN cord-005453-4057qib7 2216 10 between between IN cord-005453-4057qib7 2216 11 January January NNP cord-005453-4057qib7 2216 12 2016 2016 CD cord-005453-4057qib7 2216 13 and and CC cord-005453-4057qib7 2216 14 February February NNP cord-005453-4057qib7 2216 15 2018 2018 CD cord-005453-4057qib7 2216 16 at at IN cord-005453-4057qib7 2216 17 our -PRON- PRP$ cord-005453-4057qib7 2216 18 institution institution NN cord-005453-4057qib7 2216 19 . . . cord-005453-4057qib7 2217 1 The the DT cord-005453-4057qib7 2217 2 majority majority NN cord-005453-4057qib7 2217 3 of of IN cord-005453-4057qib7 2217 4 the the DT cord-005453-4057qib7 2217 5 patients patient NNS cord-005453-4057qib7 2217 6 ( ( -LRB- cord-005453-4057qib7 2217 7 9/11 9/11 CD cord-005453-4057qib7 2217 8 ) ) -RRB- cord-005453-4057qib7 2217 9 suffered suffer VBD cord-005453-4057qib7 2217 10 from from IN cord-005453-4057qib7 2217 11 active active JJ cord-005453-4057qib7 2217 12 disease disease NN cord-005453-4057qib7 2217 13 at at IN cord-005453-4057qib7 2217 14 time time NN cord-005453-4057qib7 2217 15 of of IN cord-005453-4057qib7 2217 16 treatment treatment NN cord-005453-4057qib7 2217 17 initiation initiation NN cord-005453-4057qib7 2217 18 , , , cord-005453-4057qib7 2217 19 only only RB cord-005453-4057qib7 2217 20 two two CD cord-005453-4057qib7 2217 21 patients patient NNS cord-005453-4057qib7 2217 22 presented present VBN cord-005453-4057qib7 2217 23 in in IN cord-005453-4057qib7 2217 24 CR CR NNP cord-005453-4057qib7 2217 25 . . . cord-005453-4057qib7 2218 1 All all DT cord-005453-4057qib7 2218 2 but but IN cord-005453-4057qib7 2218 3 one one CD cord-005453-4057qib7 2218 4 received receive VBD cord-005453-4057qib7 2218 5 sequential sequential JJ cord-005453-4057qib7 2218 6 conditioning conditioning NN cord-005453-4057qib7 2218 7 with with IN cord-005453-4057qib7 2218 8 cytoreductive cytoreductive JJ cord-005453-4057qib7 2218 9 chemotherapy chemotherapy NN cord-005453-4057qib7 2218 10 using use VBG cord-005453-4057qib7 2218 11 FLAMSA FLAMSA NNP cord-005453-4057qib7 2218 12 applied apply VBD cord-005453-4057qib7 2218 13 shortly shortly RB cord-005453-4057qib7 2218 14 prior prior RB cord-005453-4057qib7 2218 15 to to IN cord-005453-4057qib7 2218 16 treosulfan treosulfan NNP cord-005453-4057qib7 2218 17 - - HYPH cord-005453-4057qib7 2218 18 based base VBN cord-005453-4057qib7 2218 19 RIC RIC NNP cord-005453-4057qib7 2218 20 ( ( -LRB- cord-005453-4057qib7 2218 21 10g 10g NNS cord-005453-4057qib7 2218 22 / / SYM cord-005453-4057qib7 2218 23 m m NN cord-005453-4057qib7 2218 24 2 2 CD cord-005453-4057qib7 2218 25 over over IN cord-005453-4057qib7 2218 26 3 3 CD cord-005453-4057qib7 2218 27 days day NNS cord-005453-4057qib7 2218 28 ) ) -RRB- cord-005453-4057qib7 2218 29 . . . cord-005453-4057qib7 2219 1 A a DT cord-005453-4057qib7 2219 2 bone bone NN cord-005453-4057qib7 2219 3 marrow marrow NN cord-005453-4057qib7 2219 4 graft graft NN cord-005453-4057qib7 2219 5 was be VBD cord-005453-4057qib7 2219 6 used use VBN cord-005453-4057qib7 2219 7 in in IN cord-005453-4057qib7 2219 8 9/11 9/11 CD cord-005453-4057qib7 2219 9 patients patient NNS cord-005453-4057qib7 2219 10 . . . cord-005453-4057qib7 2220 1 Post post JJ cord-005453-4057qib7 2220 2 - - JJ cord-005453-4057qib7 2220 3 grafting graft VBG cord-005453-4057qib7 2220 4 immunosuppression immunosuppression NN cord-005453-4057qib7 2220 5 consisted consist VBD cord-005453-4057qib7 2220 6 of of IN cord-005453-4057qib7 2220 7 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 2220 8 , , , cord-005453-4057qib7 2220 9 tacrolimus tacrolimus NN cord-005453-4057qib7 2220 10 and and CC cord-005453-4057qib7 2220 11 MMF mmf NN cord-005453-4057qib7 2220 12 . . . cord-005453-4057qib7 2221 1 National National NNP cord-005453-4057qib7 2221 2 Cancer Cancer NNP cord-005453-4057qib7 2221 3 Institute Institute NNP cord-005453-4057qib7 2222 1 Common common JJ cord-005453-4057qib7 2222 2 Terminology terminology NN cord-005453-4057qib7 2222 3 Criteria Criteria NNP cord-005453-4057qib7 2222 4 for for IN cord-005453-4057qib7 2222 5 Adverse adverse JJ cord-005453-4057qib7 2222 6 Events Events NNPS cord-005453-4057qib7 2222 7 version version NN cord-005453-4057qib7 2222 8 3.0 3.0 CD cord-005453-4057qib7 2222 9 were be VBD cord-005453-4057qib7 2222 10 used use VBN cord-005453-4057qib7 2222 11 for for IN cord-005453-4057qib7 2222 12 nonhematologic nonhematologic JJ cord-005453-4057qib7 2222 13 toxicity toxicity NN cord-005453-4057qib7 2222 14 assessment assessment NN cord-005453-4057qib7 2222 15 starting start VBG cord-005453-4057qib7 2222 16 from from IN cord-005453-4057qib7 2222 17 sequential sequential JJ cord-005453-4057qib7 2222 18 therapy therapy NN cord-005453-4057qib7 2222 19 initiation initiation NN cord-005453-4057qib7 2222 20 or or CC cord-005453-4057qib7 2222 21 conditioning conditioning NN cord-005453-4057qib7 2222 22 until until IN cord-005453-4057qib7 2222 23 day day NN cord-005453-4057qib7 2222 24 +30 +30 CD cord-005453-4057qib7 2222 25 . . . cord-005453-4057qib7 2223 1 Results result NNS cord-005453-4057qib7 2223 2 : : : cord-005453-4057qib7 2224 1 Median median JJ cord-005453-4057qib7 2224 2 age age NN cord-005453-4057qib7 2224 3 of of IN cord-005453-4057qib7 2224 4 the the DT cord-005453-4057qib7 2224 5 entire entire JJ cord-005453-4057qib7 2224 6 cohort cohort NN cord-005453-4057qib7 2224 7 was be VBD cord-005453-4057qib7 2224 8 63 63 CD cord-005453-4057qib7 2224 9 years year NNS cord-005453-4057qib7 2225 1 ( ( -LRB- cord-005453-4057qib7 2225 2 range range NN cord-005453-4057qib7 2225 3 : : : cord-005453-4057qib7 2225 4 58 58 CD cord-005453-4057qib7 2225 5 - - SYM cord-005453-4057qib7 2225 6 71 71 CD cord-005453-4057qib7 2225 7 ) ) -RRB- cord-005453-4057qib7 2225 8 . . . cord-005453-4057qib7 2226 1 The the DT cord-005453-4057qib7 2226 2 HCT HCT NNP cord-005453-4057qib7 2226 3 - - HYPH cord-005453-4057qib7 2226 4 CI CI NNP cord-005453-4057qib7 2226 5 was be VBD cord-005453-4057qib7 2226 6 ≥2 ≥2 NNP cord-005453-4057qib7 2226 7 in in IN cord-005453-4057qib7 2226 8 eight eight CD cord-005453-4057qib7 2226 9 pts pt NNS cord-005453-4057qib7 2226 10 ( ( -LRB- cord-005453-4057qib7 2226 11 median median JJ cord-005453-4057qib7 2226 12 HCT HCT NNP cord-005453-4057qib7 2226 13 - - HYPH cord-005453-4057qib7 2226 14 CI=2 CI=2 NNP cord-005453-4057qib7 2226 15 , , , cord-005453-4057qib7 2226 16 range range NN cord-005453-4057qib7 2226 17 : : : cord-005453-4057qib7 2226 18 0 0 CD cord-005453-4057qib7 2226 19 - - SYM cord-005453-4057qib7 2226 20 5 5 CD cord-005453-4057qib7 2226 21 ) ) -RRB- cord-005453-4057qib7 2226 22 . . . cord-005453-4057qib7 2227 1 No no DT cord-005453-4057qib7 2227 2 graft graft NN cord-005453-4057qib7 2227 3 rejection rejection NN cord-005453-4057qib7 2227 4 occurred occur VBD cord-005453-4057qib7 2227 5 . . . cord-005453-4057qib7 2228 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 2228 2 and and CC cord-005453-4057qib7 2228 3 platelet platelet NN cord-005453-4057qib7 2228 4 engraftment engraftment NN cord-005453-4057qib7 2228 5 were be VBD cord-005453-4057qib7 2228 6 achieved achieve VBN cord-005453-4057qib7 2228 7 in in IN cord-005453-4057qib7 2228 8 100 100 CD cord-005453-4057qib7 2228 9 % % NN cord-005453-4057qib7 2228 10 and and CC cord-005453-4057qib7 2228 11 91 91 CD cord-005453-4057qib7 2228 12 % % NN cord-005453-4057qib7 2228 13 of of IN cord-005453-4057qib7 2228 14 the the DT cord-005453-4057qib7 2228 15 patients patient NNS cord-005453-4057qib7 2228 16 at at IN cord-005453-4057qib7 2228 17 a a DT cord-005453-4057qib7 2228 18 median median NN cord-005453-4057qib7 2228 19 of of IN cord-005453-4057qib7 2228 20 20 20 CD cord-005453-4057qib7 2228 21 ( ( -LRB- cord-005453-4057qib7 2228 22 16 16 CD cord-005453-4057qib7 2228 23 - - SYM cord-005453-4057qib7 2228 24 23 23 CD cord-005453-4057qib7 2228 25 ) ) -RRB- cord-005453-4057qib7 2228 26 and and CC cord-005453-4057qib7 2228 27 26.5 26.5 CD cord-005453-4057qib7 2228 28 ( ( -LRB- cord-005453-4057qib7 2228 29 13 13 CD cord-005453-4057qib7 2228 30 - - SYM cord-005453-4057qib7 2228 31 30 30 CD cord-005453-4057qib7 2228 32 ) ) -RRB- cord-005453-4057qib7 2228 33 days day NNS cord-005453-4057qib7 2228 34 , , , cord-005453-4057qib7 2228 35 respectively respectively RB cord-005453-4057qib7 2228 36 . . . cord-005453-4057qib7 2229 1 Acute acute JJ cord-005453-4057qib7 2229 2 GvHD GvHD NNP cord-005453-4057qib7 2229 3 grade grade NN cord-005453-4057qib7 2229 4 II II NNP cord-005453-4057qib7 2229 5 - - HYPH cord-005453-4057qib7 2229 6 IV IV NNP cord-005453-4057qib7 2229 7 occurred occur VBD cord-005453-4057qib7 2229 8 in in IN cord-005453-4057qib7 2229 9 18 18 CD cord-005453-4057qib7 2229 10 % % NN cord-005453-4057qib7 2229 11 of of IN cord-005453-4057qib7 2229 12 the the DT cord-005453-4057qib7 2229 13 patients patient NNS cord-005453-4057qib7 2229 14 , , , cord-005453-4057qib7 2229 15 exclusively exclusively RB cord-005453-4057qib7 2229 16 involving involve VBG cord-005453-4057qib7 2229 17 the the DT cord-005453-4057qib7 2229 18 skin skin NN cord-005453-4057qib7 2229 19 . . . cord-005453-4057qib7 2230 1 No no DT cord-005453-4057qib7 2230 2 one one NN cord-005453-4057qib7 2230 3 developed develop VBD cord-005453-4057qib7 2230 4 severe severe JJ cord-005453-4057qib7 2230 5 ( ( -LRB- cord-005453-4057qib7 2230 6 ° ° JJ cord-005453-4057qib7 2230 7 III III NNP cord-005453-4057qib7 2230 8 - - HYPH cord-005453-4057qib7 2230 9 IV IV NNP cord-005453-4057qib7 2230 10 ) ) -RRB- cord-005453-4057qib7 2230 11 acute acute JJ cord-005453-4057qib7 2230 12 GvHD GvHD NNP cord-005453-4057qib7 2230 13 . . . cord-005453-4057qib7 2231 1 No no DT cord-005453-4057qib7 2231 2 patient patient NN cord-005453-4057qib7 2231 3 died die VBD cord-005453-4057qib7 2231 4 prior prior RB cord-005453-4057qib7 2231 5 to to IN cord-005453-4057qib7 2231 6 haplo haplo NNP cord-005453-4057qib7 2231 7 - - HYPH cord-005453-4057qib7 2231 8 HSCT HSCT NNP cord-005453-4057qib7 2231 9 . . . cord-005453-4057qib7 2232 1 Severe severe JJ cord-005453-4057qib7 2232 2 nonhematologic nonhematologic JJ cord-005453-4057qib7 2232 3 regimen regimen NN cord-005453-4057qib7 2232 4 - - HYPH cord-005453-4057qib7 2232 5 related relate VBN cord-005453-4057qib7 2232 6 toxicities toxicity NNS cord-005453-4057qib7 2232 7 ( ( -LRB- cord-005453-4057qib7 2232 8 ° ° JJ cord-005453-4057qib7 2232 9 III III NNP cord-005453-4057qib7 2232 10 - - HYPH cord-005453-4057qib7 2232 11 IV IV NNP cord-005453-4057qib7 2232 12 ) ) -RRB- cord-005453-4057qib7 2232 13 occurred occur VBD cord-005453-4057qib7 2232 14 in in IN cord-005453-4057qib7 2232 15 2/11 2/11 CD cord-005453-4057qib7 2232 16 patients patient NNS cord-005453-4057qib7 2232 17 , , , cord-005453-4057qib7 2232 18 predominately predominately RB cord-005453-4057qib7 2232 19 affecting affect VBG cord-005453-4057qib7 2232 20 the the DT cord-005453-4057qib7 2232 21 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 2232 22 tract tract NN cord-005453-4057qib7 2232 23 . . . cord-005453-4057qib7 2233 1 No no DT cord-005453-4057qib7 2233 2 patient patient NN cord-005453-4057qib7 2233 3 suffered suffer VBD cord-005453-4057qib7 2233 4 from from IN cord-005453-4057qib7 2233 5 ≥two ≥two CD cord-005453-4057qib7 2233 6 III III NNP cord-005453-4057qib7 2233 7 - - HYPH cord-005453-4057qib7 2233 8 IV IV NNP cord-005453-4057qib7 2233 9 ° ° NNS cord-005453-4057qib7 2233 10 toxicities toxicity NNS cord-005453-4057qib7 2233 11 . . . cord-005453-4057qib7 2234 1 All all DT cord-005453-4057qib7 2234 2 patients patient NNS cord-005453-4057qib7 2234 3 developed develop VBD cord-005453-4057qib7 2234 4 fever fever NN cord-005453-4057qib7 2234 5 during during IN cord-005453-4057qib7 2234 6 treatment treatment NN cord-005453-4057qib7 2234 7 course course NN cord-005453-4057qib7 2234 8 , , , cord-005453-4057qib7 2234 9 four four CD cord-005453-4057qib7 2234 10 with with IN cord-005453-4057qib7 2234 11 positive positive JJ cord-005453-4057qib7 2234 12 blood blood NN cord-005453-4057qib7 2234 13 cultures culture NNS cord-005453-4057qib7 2234 14 . . . cord-005453-4057qib7 2235 1 CMV CMV NNP cord-005453-4057qib7 2235 2 reactivated reactivate VBD cord-005453-4057qib7 2235 3 in in IN cord-005453-4057qib7 2235 4 6/7 6/7 CD cord-005453-4057qib7 2235 5 patients patient NNS cord-005453-4057qib7 2235 6 at at IN cord-005453-4057qib7 2235 7 risk risk NN cord-005453-4057qib7 2235 8 . . . cord-005453-4057qib7 2236 1 No no DT cord-005453-4057qib7 2236 2 EBV EBV NNP cord-005453-4057qib7 2236 3 reactivation reactivation NN cord-005453-4057qib7 2236 4 or or CC cord-005453-4057qib7 2236 5 PTLD PTLD NNP cord-005453-4057qib7 2236 6 occurred occur VBD cord-005453-4057qib7 2236 7 . . . cord-005453-4057qib7 2237 1 Six six CD cord-005453-4057qib7 2237 2 patients patient NNS cord-005453-4057qib7 2237 3 had have VBD cord-005453-4057qib7 2237 4 clinical clinical JJ cord-005453-4057qib7 2237 5 and and CC cord-005453-4057qib7 2237 6 radiological radiological JJ cord-005453-4057qib7 2237 7 signs sign NNS cord-005453-4057qib7 2237 8 of of IN cord-005453-4057qib7 2237 9 pneumonia pneumonia NN cord-005453-4057qib7 2237 10 ( ( -LRB- cord-005453-4057qib7 2237 11 probable probable JJ cord-005453-4057qib7 2237 12 invasive invasive JJ cord-005453-4057qib7 2237 13 aspergillosis aspergillosis NN cord-005453-4057qib7 2237 14 ) ) -RRB- cord-005453-4057qib7 2237 15 without without IN cord-005453-4057qib7 2237 16 detection detection NN cord-005453-4057qib7 2237 17 of of IN cord-005453-4057qib7 2237 18 aspergillus aspergillus NN cord-005453-4057qib7 2237 19 / / SYM cord-005453-4057qib7 2237 20 antigen antigen NN cord-005453-4057qib7 2237 21 in in IN cord-005453-4057qib7 2237 22 the the DT cord-005453-4057qib7 2237 23 bronchoalveolar bronchoalveolar NNP cord-005453-4057qib7 2237 24 lavage lavage NN cord-005453-4057qib7 2237 25 . . . cord-005453-4057qib7 2238 1 CI CI NNP cord-005453-4057qib7 2238 2 of of IN cord-005453-4057qib7 2238 3 NRM NRM NNP cord-005453-4057qib7 2238 4 at at IN cord-005453-4057qib7 2238 5 day day NN cord-005453-4057qib7 2238 6 +180 +180 NNP cord-005453-4057qib7 2238 7 was be VBD cord-005453-4057qib7 2238 8 0 0 CD cord-005453-4057qib7 2238 9 % % NN cord-005453-4057qib7 2238 10 . . . cord-005453-4057qib7 2239 1 Four four CD cord-005453-4057qib7 2239 2 patients patient NNS cord-005453-4057qib7 2239 3 relapsed relapse VBD cord-005453-4057qib7 2239 4 within within IN cord-005453-4057qib7 2239 5 the the DT cord-005453-4057qib7 2239 6 first first JJ cord-005453-4057qib7 2239 7 year year NN cord-005453-4057qib7 2239 8 after after IN cord-005453-4057qib7 2239 9 haplo haplo NNP cord-005453-4057qib7 2239 10 - - HYPH cord-005453-4057qib7 2239 11 HSCT HSCT NNP cord-005453-4057qib7 2239 12 , , , cord-005453-4057qib7 2239 13 with with IN cord-005453-4057qib7 2239 14 two two CD cord-005453-4057qib7 2239 15 of of IN cord-005453-4057qib7 2239 16 them -PRON- PRP cord-005453-4057qib7 2239 17 dying die VBG cord-005453-4057qib7 2239 18 due due IN cord-005453-4057qib7 2239 19 to to IN cord-005453-4057qib7 2239 20 relapse relapse NN cord-005453-4057qib7 2239 21 . . . cord-005453-4057qib7 2240 1 At at IN cord-005453-4057qib7 2240 2 last last JJ cord-005453-4057qib7 2240 3 follow follow NN cord-005453-4057qib7 2240 4 - - HYPH cord-005453-4057qib7 2240 5 up up NN cord-005453-4057qib7 2240 6 ( ( -LRB- cord-005453-4057qib7 2240 7 Dec Dec NNP cord-005453-4057qib7 2240 8 2018 2018 CD cord-005453-4057qib7 2240 9 ) ) -RRB- cord-005453-4057qib7 2240 10 9/11 9/11 CD cord-005453-4057qib7 2240 11 patients patient NNS cord-005453-4057qib7 2240 12 were be VBD cord-005453-4057qib7 2240 13 alive alive JJ cord-005453-4057qib7 2240 14 . . . cord-005453-4057qib7 2241 1 With with IN cord-005453-4057qib7 2241 2 a a DT cord-005453-4057qib7 2241 3 median median JJ cord-005453-4057qib7 2241 4 follow follow NN cord-005453-4057qib7 2241 5 - - HYPH cord-005453-4057qib7 2241 6 up up NN cord-005453-4057qib7 2241 7 of of IN cord-005453-4057qib7 2241 8 5 5 CD cord-005453-4057qib7 2241 9 months month NNS cord-005453-4057qib7 2241 10 ( ( -LRB- cord-005453-4057qib7 2241 11 2 2 CD cord-005453-4057qib7 2241 12 - - SYM cord-005453-4057qib7 2241 13 31 31 CD cord-005453-4057qib7 2241 14 ) ) -RRB- cord-005453-4057qib7 2241 15 estimated estimate VBD cord-005453-4057qib7 2241 16 1-year 1-year CD cord-005453-4057qib7 2241 17 OS OS NNP cord-005453-4057qib7 2241 18 and and CC cord-005453-4057qib7 2241 19 DFS DFS NNP cord-005453-4057qib7 2241 20 were be VBD cord-005453-4057qib7 2241 21 80 80 CD cord-005453-4057qib7 2241 22 % % NN cord-005453-4057qib7 2241 23 and and CC cord-005453-4057qib7 2241 24 59 59 CD cord-005453-4057qib7 2241 25 % % NN cord-005453-4057qib7 2241 26 , , , cord-005453-4057qib7 2241 27 respectively respectively RB cord-005453-4057qib7 2241 28 . . . cord-005453-4057qib7 2242 1 Conclusions conclusion NNS cord-005453-4057qib7 2242 2 : : : cord-005453-4057qib7 2243 1 Treosulfan Treosulfan NNP cord-005453-4057qib7 2243 2 - - HYPH cord-005453-4057qib7 2243 3 based base VBN cord-005453-4057qib7 2243 4 unmanipulated unmanipulated JJ cord-005453-4057qib7 2243 5 HLAhaploidentical hlahaploidentical JJ cord-005453-4057qib7 2243 6 allo allo NN cord-005453-4057qib7 2243 7 - - HYPH cord-005453-4057qib7 2243 8 grafting grafting NN cord-005453-4057qib7 2243 9 using use VBG cord-005453-4057qib7 2243 10 PTCY PTCY NNP cord-005453-4057qib7 2243 11 as as IN cord-005453-4057qib7 2243 12 GvHD GvHD NNP cord-005453-4057qib7 2243 13 prophylaxis prophylaxis NN cord-005453-4057qib7 2243 14 in in IN cord-005453-4057qib7 2243 15 HR HR NNP cord-005453-4057qib7 2243 16 MDS MDS NNP cord-005453-4057qib7 2243 17 and and CC cord-005453-4057qib7 2243 18 AML AML NNP cord-005453-4057qib7 2243 19 patients patient NNS cord-005453-4057qib7 2243 20 aged age VBN cord-005453-4057qib7 2243 21 over over IN cord-005453-4057qib7 2243 22 55 55 CD cord-005453-4057qib7 2243 23 years year NNS cord-005453-4057qib7 2243 24 is be VBZ cord-005453-4057qib7 2243 25 safe safe JJ cord-005453-4057qib7 2243 26 and and CC cord-005453-4057qib7 2243 27 well well RB cord-005453-4057qib7 2243 28 tolerated tolerate VBN cord-005453-4057qib7 2243 29 resulting result VBG cord-005453-4057qib7 2243 30 in in IN cord-005453-4057qib7 2243 31 stable stable JJ cord-005453-4057qib7 2243 32 engraftment engraftment NN cord-005453-4057qib7 2243 33 and and CC cord-005453-4057qib7 2243 34 a a DT cord-005453-4057qib7 2243 35 favorable favorable JJ cord-005453-4057qib7 2243 36 toxicity toxicity NN cord-005453-4057qib7 2243 37 profile profile NN cord-005453-4057qib7 2243 38 . . . cord-005453-4057qib7 2244 1 Our -PRON- PRP$ cord-005453-4057qib7 2244 2 preliminary preliminary JJ cord-005453-4057qib7 2244 3 data datum NNS cord-005453-4057qib7 2244 4 further far RBR cord-005453-4057qib7 2244 5 show show VBP cord-005453-4057qib7 2244 6 promising promising JJ cord-005453-4057qib7 2244 7 outcome outcome NN cord-005453-4057qib7 2244 8 with with IN cord-005453-4057qib7 2244 9 low low JJ cord-005453-4057qib7 2244 10 NRM NRM NNP cord-005453-4057qib7 2244 11 , , , cord-005453-4057qib7 2244 12 no no DT cord-005453-4057qib7 2244 13 severe severe JJ cord-005453-4057qib7 2244 14 acute acute JJ cord-005453-4057qib7 2244 15 GvHD gvhd NN cord-005453-4057qib7 2244 16 and and CC cord-005453-4057qib7 2244 17 favorable favorable JJ cord-005453-4057qib7 2244 18 survival survival NN cord-005453-4057qib7 2244 19 offering offer VBG cord-005453-4057qib7 2244 20 an an DT cord-005453-4057qib7 2244 21 attractive attractive JJ cord-005453-4057qib7 2244 22 alternative alternative NN cord-005453-4057qib7 2244 23 in in IN cord-005453-4057qib7 2244 24 RIC RIC NNP cord-005453-4057qib7 2244 25 for for IN cord-005453-4057qib7 2244 26 haplo haplo NNP cord-005453-4057qib7 2244 27 - - HYPH cord-005453-4057qib7 2244 28 HSCT HSCT NNP cord-005453-4057qib7 2244 29 of of IN cord-005453-4057qib7 2244 30 the the DT cord-005453-4057qib7 2244 31 elderly elderly JJ cord-005453-4057qib7 2244 32 . . . cord-005453-4057qib7 2245 1 Disclosure disclosure NN cord-005453-4057qib7 2245 2 : : : cord-005453-4057qib7 2245 3 nothing nothing NN cord-005453-4057qib7 2245 4 to to TO cord-005453-4057qib7 2245 5 declare declare VB cord-005453-4057qib7 2245 6 Comparison comparison NN cord-005453-4057qib7 2245 7 of of IN cord-005453-4057qib7 2245 8 outcomes outcome NNS cord-005453-4057qib7 2245 9 of of IN cord-005453-4057qib7 2245 10 total total JJ cord-005453-4057qib7 2245 11 body body NN cord-005453-4057qib7 2245 12 irradiation irradiation NN cord-005453-4057qib7 2245 13 ( ( -LRB- cord-005453-4057qib7 2245 14 TBI TBI NNP cord-005453-4057qib7 2245 15 ) ) -RRB- cord-005453-4057qib7 2245 16 vs vs IN cord-005453-4057qib7 2245 17 non non JJ cord-005453-4057qib7 2245 18 - - JJ cord-005453-4057qib7 2245 19 TBI tbi JJ cord-005453-4057qib7 2245 20 conditioning conditioning NN cord-005453-4057qib7 2245 21 regimens regimen NNS cord-005453-4057qib7 2245 22 in in IN cord-005453-4057qib7 2245 23 acute acute JJ cord-005453-4057qib7 2245 24 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 2245 25 leukemia leukemia NN cord-005453-4057qib7 2245 26 for for IN cord-005453-4057qib7 2245 27 allogeneic allogeneic NN cord-005453-4057qib7 2245 28 transplantation transplantation NN cord-005453-4057qib7 2245 29 Background background NN cord-005453-4057qib7 2245 30 : : : cord-005453-4057qib7 2246 1 In in IN cord-005453-4057qib7 2246 2 adult adult NN cord-005453-4057qib7 2246 3 patients patient NNS cord-005453-4057qib7 2246 4 diagnosed diagnose VBD cord-005453-4057qib7 2246 5 acute acute JJ cord-005453-4057qib7 2246 6 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 2246 7 leukemia leukemia NN cord-005453-4057qib7 2246 8 ( ( -LRB- cord-005453-4057qib7 2246 9 ALL all DT cord-005453-4057qib7 2246 10 ) ) -RRB- cord-005453-4057qib7 2246 11 long long JJ cord-005453-4057qib7 2246 12 - - HYPH cord-005453-4057qib7 2246 13 term term NN cord-005453-4057qib7 2246 14 results result NNS cord-005453-4057qib7 2246 15 are be VBP cord-005453-4057qib7 2246 16 poor poor JJ cord-005453-4057qib7 2246 17 with with IN cord-005453-4057qib7 2246 18 intensive intensive JJ cord-005453-4057qib7 2246 19 chemotherapy chemotherapy NN cord-005453-4057qib7 2246 20 . . . cord-005453-4057qib7 2247 1 Allogeneic allogeneic IN cord-005453-4057qib7 2247 2 stem stem VB cord-005453-4057qib7 2247 3 stem stem NN cord-005453-4057qib7 2247 4 cell cell NN cord-005453-4057qib7 2247 5 transplantation transplantation NN cord-005453-4057qib7 2247 6 is be VBZ cord-005453-4057qib7 2247 7 the the DT cord-005453-4057qib7 2247 8 potential potential JJ cord-005453-4057qib7 2247 9 treatment treatment NN cord-005453-4057qib7 2247 10 that that WDT cord-005453-4057qib7 2247 11 provides provide VBZ cord-005453-4057qib7 2247 12 cure cure NN cord-005453-4057qib7 2247 13 for for IN cord-005453-4057qib7 2247 14 these these DT cord-005453-4057qib7 2247 15 patients patient NNS cord-005453-4057qib7 2247 16 . . . cord-005453-4057qib7 2248 1 Myeloablative myeloablative JJ cord-005453-4057qib7 2248 2 preparation preparation NN cord-005453-4057qib7 2248 3 regimens regimen NNS cord-005453-4057qib7 2248 4 include include VBP cord-005453-4057qib7 2248 5 total total JJ cord-005453-4057qib7 2248 6 body body NN cord-005453-4057qib7 2248 7 irradiation irradiation NN cord-005453-4057qib7 2248 8 ( ( -LRB- cord-005453-4057qib7 2248 9 TBİ)+ TBİ)+ NNP cord-005453-4057qib7 2248 10 cyclophosphamide(Cy cyclophosphamide(Cy NNP cord-005453-4057qib7 2248 11 ) ) -RRB- cord-005453-4057qib7 2248 12 and and CC cord-005453-4057qib7 2248 13 busulfan busulfan NN cord-005453-4057qib7 2248 14 + + CC cord-005453-4057qib7 2248 15 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 2248 16 . . . cord-005453-4057qib7 2249 1 In in IN cord-005453-4057qib7 2249 2 adult adult NN cord-005453-4057qib7 2249 3 ALL all DT cord-005453-4057qib7 2249 4 patients patient NNS cord-005453-4057qib7 2249 5 WBI WBI NNP cord-005453-4057qib7 2249 6 / / SYM cord-005453-4057qib7 2249 7 Cy Cy NNP cord-005453-4057qib7 2249 8 widely widely RB cord-005453-4057qib7 2249 9 used use VBD cord-005453-4057qib7 2249 10 , , , cord-005453-4057qib7 2249 11 but but CC cord-005453-4057qib7 2249 12 the the DT cord-005453-4057qib7 2249 13 toxicity toxicity NN cord-005453-4057qib7 2249 14 rate rate NN cord-005453-4057qib7 2249 15 is be VBZ cord-005453-4057qib7 2249 16 higher high JJR cord-005453-4057qib7 2249 17 . . . cord-005453-4057qib7 2250 1 The the DT cord-005453-4057qib7 2250 2 aim aim NN cord-005453-4057qib7 2250 3 of of IN cord-005453-4057qib7 2250 4 this this DT cord-005453-4057qib7 2250 5 study study NN cord-005453-4057qib7 2250 6 is be VBZ cord-005453-4057qib7 2250 7 to to TO cord-005453-4057qib7 2250 8 compare compare VB cord-005453-4057qib7 2250 9 the the DT cord-005453-4057qib7 2250 10 result result NN cord-005453-4057qib7 2250 11 and and CC cord-005453-4057qib7 2250 12 effect effect NN cord-005453-4057qib7 2250 13 of of IN cord-005453-4057qib7 2250 14 the the DT cord-005453-4057qib7 2250 15 TBI TBI NNP cord-005453-4057qib7 2250 16 / / SYM cord-005453-4057qib7 2250 17 Cy Cy NNP cord-005453-4057qib7 2250 18 and and CC cord-005453-4057qib7 2250 19 busulfan busulfan NNP cord-005453-4057qib7 2250 20 / / SYM cord-005453-4057qib7 2250 21 Cy Cy NNP cord-005453-4057qib7 2250 22 regimens regimen NNS cord-005453-4057qib7 2250 23 in in IN cord-005453-4057qib7 2250 24 Allogenic Allogenic NNP cord-005453-4057qib7 2250 25 bone bone NN cord-005453-4057qib7 2250 26 marrow marrow NN cord-005453-4057qib7 2250 27 transplantation transplantation NN cord-005453-4057qib7 2250 28 in in IN cord-005453-4057qib7 2250 29 ALL all DT cord-005453-4057qib7 2250 30 patients patient NNS cord-005453-4057qib7 2250 31 . . . cord-005453-4057qib7 2251 1 Methods method NNS cord-005453-4057qib7 2251 2 : : : cord-005453-4057qib7 2252 1 Between between IN cord-005453-4057qib7 2252 2 1993 1993 CD cord-005453-4057qib7 2252 3 -2018 -2018 NNS cord-005453-4057qib7 2252 4 there there EX cord-005453-4057qib7 2252 5 were be VBD cord-005453-4057qib7 2252 6 137 137 CD cord-005453-4057qib7 2252 7 ALL all DT cord-005453-4057qib7 2252 8 patients patient NNS cord-005453-4057qib7 2252 9 who who WP cord-005453-4057qib7 2252 10 underwent undergo VBD cord-005453-4057qib7 2252 11 transplantation transplantation NN cord-005453-4057qib7 2252 12 using use VBG cord-005453-4057qib7 2252 13 myeloablative myeloablative JJ cord-005453-4057qib7 2252 14 preparation preparation NN cord-005453-4057qib7 2252 15 regimen regimen NN cord-005453-4057qib7 2252 16 with with IN cord-005453-4057qib7 2252 17 or or CC cord-005453-4057qib7 2252 18 without without IN cord-005453-4057qib7 2252 19 addition addition NN cord-005453-4057qib7 2252 20 TBI TBI NNP cord-005453-4057qib7 2252 21 in in IN cord-005453-4057qib7 2252 22 the the DT cord-005453-4057qib7 2252 23 adult adult NN cord-005453-4057qib7 2252 24 bone bone NN cord-005453-4057qib7 2252 25 marrow marrow NN cord-005453-4057qib7 2252 26 transplantation transplantation NN cord-005453-4057qib7 2252 27 units unit NNS cord-005453-4057qib7 2252 28 of of IN cord-005453-4057qib7 2252 29 Medipol Medipol NNP cord-005453-4057qib7 2252 30 Medical Medical NNP cord-005453-4057qib7 2252 31 Faculty Faculty NNP cord-005453-4057qib7 2252 32 , , , cord-005453-4057qib7 2252 33 Istanbul Istanbul NNP cord-005453-4057qib7 2252 34 University University NNP cord-005453-4057qib7 2252 35 Istanbul Istanbul NNP cord-005453-4057qib7 2252 36 Medical Medical NNP cord-005453-4057qib7 2252 37 Faculty Faculty NNP cord-005453-4057qib7 2252 38 , , , cord-005453-4057qib7 2252 39 Sisli Sisli NNP cord-005453-4057qib7 2252 40 Florence Florence NNP cord-005453-4057qib7 2252 41 Nightingale Nightingale NNP cord-005453-4057qib7 2252 42 Hospital Hospital NNP cord-005453-4057qib7 2252 43 , , , cord-005453-4057qib7 2252 44 Atakent Atakent NNP cord-005453-4057qib7 2252 45 Acıbadem Acıbadem NNP cord-005453-4057qib7 2252 46 Hospital Hospital NNP cord-005453-4057qib7 2252 47 adult adult NN cord-005453-4057qib7 2252 48 bone bone NN cord-005453-4057qib7 2252 49 marrow marrow NN cord-005453-4057qib7 2252 50 units unit NNS cord-005453-4057qib7 2252 51 . . . cord-005453-4057qib7 2253 1 We -PRON- PRP cord-005453-4057qib7 2253 2 analyzed analyze VBD cord-005453-4057qib7 2253 3 overall overall JJ cord-005453-4057qib7 2253 4 survival survival NN cord-005453-4057qib7 2253 5 ( ( -LRB- cord-005453-4057qib7 2253 6 OS OS NNP cord-005453-4057qib7 2253 7 ) ) -RRB- cord-005453-4057qib7 2253 8 , , , cord-005453-4057qib7 2253 9 progression progression NN cord-005453-4057qib7 2253 10 free free JJ cord-005453-4057qib7 2253 11 survival survival NN cord-005453-4057qib7 2253 12 ( ( -LRB- cord-005453-4057qib7 2253 13 PFS PFS NNP cord-005453-4057qib7 2253 14 ) ) -RRB- cord-005453-4057qib7 2253 15 , , , cord-005453-4057qib7 2253 16 veno veno NNP cord-005453-4057qib7 2253 17 occlusive occlusive NNP cord-005453-4057qib7 2253 18 disease disease NN cord-005453-4057qib7 2253 19 , , , cord-005453-4057qib7 2253 20 acute acute JJ cord-005453-4057qib7 2253 21 and and CC cord-005453-4057qib7 2253 22 chronic chronic JJ cord-005453-4057qib7 2253 23 graft graft NN cord-005453-4057qib7 2253 24 versus versus IN cord-005453-4057qib7 2253 25 disease disease NN cord-005453-4057qib7 2253 26 development development NN cord-005453-4057qib7 2253 27 rates rate NNS cord-005453-4057qib7 2253 28 in in IN cord-005453-4057qib7 2253 29 these these DT cord-005453-4057qib7 2253 30 patients patient NNS cord-005453-4057qib7 2253 31 . . . cord-005453-4057qib7 2254 1 Results result NNS cord-005453-4057qib7 2254 2 : : : cord-005453-4057qib7 2255 1 Demographic demographic JJ cord-005453-4057qib7 2255 2 characteristics characteristic NNS cord-005453-4057qib7 2255 3 of of IN cord-005453-4057qib7 2255 4 patients patient NNS cord-005453-4057qib7 2255 5 summarized summarize VBN cord-005453-4057qib7 2255 6 in in IN cord-005453-4057qib7 2255 7 table table NN cord-005453-4057qib7 2255 8 -1 -1 . cord-005453-4057qib7 2256 1 There there EX cord-005453-4057qib7 2256 2 was be VBD cord-005453-4057qib7 2256 3 no no DT cord-005453-4057qib7 2256 4 significant significant JJ cord-005453-4057qib7 2256 5 difference difference NN cord-005453-4057qib7 2256 6 between between IN cord-005453-4057qib7 2256 7 groups group NNS cord-005453-4057qib7 2256 8 in in IN cord-005453-4057qib7 2256 9 donor donor NN cord-005453-4057qib7 2256 10 age age NN cord-005453-4057qib7 2256 11 , , , cord-005453-4057qib7 2256 12 gender gender NN cord-005453-4057qib7 2256 13 , , , cord-005453-4057qib7 2256 14 stem stem NN cord-005453-4057qib7 2256 15 cell cell NN cord-005453-4057qib7 2256 16 source source NN cord-005453-4057qib7 2256 17 . . . cord-005453-4057qib7 2257 1 It -PRON- PRP cord-005453-4057qib7 2257 2 was be VBD cord-005453-4057qib7 2257 3 observed observe VBN cord-005453-4057qib7 2257 4 that that IN cord-005453-4057qib7 2257 5 the the DT cord-005453-4057qib7 2257 6 relapse relapse NN cord-005453-4057qib7 2257 7 rate rate NN cord-005453-4057qib7 2257 8 was be VBD cord-005453-4057qib7 2257 9 not not RB cord-005453-4057qib7 2257 10 statistically statistically RB cord-005453-4057qib7 2257 11 significant significant JJ cord-005453-4057qib7 2257 12 in in IN cord-005453-4057qib7 2257 13 both both DT cord-005453-4057qib7 2257 14 group group NN cord-005453-4057qib7 2257 15 . . . cord-005453-4057qib7 2258 1 There there EX cord-005453-4057qib7 2258 2 was be VBD cord-005453-4057qib7 2258 3 no no DT cord-005453-4057qib7 2258 4 statistically statistically RB cord-005453-4057qib7 2258 5 significant significant JJ cord-005453-4057qib7 2258 6 difference difference NN cord-005453-4057qib7 2258 7 between between IN cord-005453-4057qib7 2258 8 the the DT cord-005453-4057qib7 2258 9 patients patient NNS cord-005453-4057qib7 2258 10 who who WP cord-005453-4057qib7 2258 11 underwent undergo VBD cord-005453-4057qib7 2258 12 myeloablative myeloablative JJ cord-005453-4057qib7 2258 13 regimen regimen NN cord-005453-4057qib7 2258 14 and and CC cord-005453-4057qib7 2258 15 myeloablative myeloablative NNP cord-005453-4057qib7 2258 16 regimen regimen NN cord-005453-4057qib7 2258 17 with with IN cord-005453-4057qib7 2258 18 TBI TBI NNP cord-005453-4057qib7 2258 19 in in IN cord-005453-4057qib7 2258 20 relaps relap NNS cord-005453-4057qib7 2258 21 , , , cord-005453-4057qib7 2258 22 death death NN cord-005453-4057qib7 2258 23 , , , cord-005453-4057qib7 2258 24 OS OS NNP cord-005453-4057qib7 2258 25 , , , cord-005453-4057qib7 2258 26 PFS PFS NNP cord-005453-4057qib7 2258 27 . . . cord-005453-4057qib7 2259 1 ( ( -LRB- cord-005453-4057qib7 2259 2 figure-1 figure-1 NNP cord-005453-4057qib7 2259 3 ) ) -RRB- cord-005453-4057qib7 2260 1 [ [ -LRB- cord-005453-4057qib7 2260 2 [ [ -LRB- cord-005453-4057qib7 2260 3 P117 P117 NNP cord-005453-4057qib7 2260 4 Image image NN cord-005453-4057qib7 2260 5 ] ] -RRB- cord-005453-4057qib7 2260 6 1 1 CD cord-005453-4057qib7 2260 7 . . . cord-005453-4057qib7 2261 1 Figure figure NN cord-005453-4057qib7 2261 2 1 1 CD cord-005453-4057qib7 2261 3 ] ] -RRB- cord-005453-4057qib7 2262 1 In in IN cord-005453-4057qib7 2262 2 terms term NNS cord-005453-4057qib7 2262 3 of of IN cord-005453-4057qib7 2262 4 transplant transplant NN cord-005453-4057qib7 2262 5 complications complication NNS cord-005453-4057qib7 2262 6 there there EX cord-005453-4057qib7 2262 7 was be VBD cord-005453-4057qib7 2262 8 also also RB cord-005453-4057qib7 2262 9 no no DT cord-005453-4057qib7 2262 10 respectable respectable JJ cord-005453-4057qib7 2262 11 difference difference NN cord-005453-4057qib7 2262 12 in in IN cord-005453-4057qib7 2262 13 development development NN cord-005453-4057qib7 2262 14 of of IN cord-005453-4057qib7 2262 15 VOD VOD NNP cord-005453-4057qib7 2262 16 and and CC cord-005453-4057qib7 2262 17 acute acute JJ cord-005453-4057qib7 2262 18 and and CC cord-005453-4057qib7 2262 19 chronic chronic JJ cord-005453-4057qib7 2262 20 graft graft NN cord-005453-4057qib7 2262 21 versus versus IN cord-005453-4057qib7 2262 22 disease disease NN cord-005453-4057qib7 2262 23 but but CC cord-005453-4057qib7 2262 24 VOD VOD NNP cord-005453-4057qib7 2262 25 was be VBD cord-005453-4057qib7 2262 26 more more RBR cord-005453-4057qib7 2262 27 common common JJ cord-005453-4057qib7 2262 28 in in IN cord-005453-4057qib7 2262 29 the the DT cord-005453-4057qib7 2262 30 group group NN cord-005453-4057qib7 2262 31 that that WDT cord-005453-4057qib7 2262 32 did do VBD cord-005453-4057qib7 2262 33 not not RB cord-005453-4057qib7 2262 34 use use VB cord-005453-4057qib7 2262 35 TBI TBI NNP cord-005453-4057qib7 2262 36 ( ( -LRB- cord-005453-4057qib7 2262 37 P p NN cord-005453-4057qib7 2262 38 : : : cord-005453-4057qib7 2262 39 0.068 0.068 CD cord-005453-4057qib7 2262 40 ) ) -RRB- cord-005453-4057qib7 2263 1 ( ( -LRB- cord-005453-4057qib7 2263 2 Conclusions conclusion NNS cord-005453-4057qib7 2263 3 : : : cord-005453-4057qib7 2264 1 Although although IN cord-005453-4057qib7 2264 2 there there EX cord-005453-4057qib7 2264 3 are be VBP cord-005453-4057qib7 2264 4 contradictory contradictory JJ cord-005453-4057qib7 2264 5 data datum NNS cord-005453-4057qib7 2264 6 in in IN cord-005453-4057qib7 2264 7 the the DT cord-005453-4057qib7 2264 8 literature literature NN cord-005453-4057qib7 2264 9 , , , cord-005453-4057qib7 2264 10 in in IN cord-005453-4057qib7 2264 11 our -PRON- PRP$ cord-005453-4057qib7 2264 12 multicentre multicentre NNP cord-005453-4057qib7 2264 13 study study NN cord-005453-4057qib7 2264 14 , , , cord-005453-4057qib7 2264 15 it -PRON- PRP cord-005453-4057qib7 2264 16 was be VBD cord-005453-4057qib7 2264 17 revealed reveal VBN cord-005453-4057qib7 2264 18 that that IN cord-005453-4057qib7 2264 19 the the DT cord-005453-4057qib7 2264 20 addition addition NN cord-005453-4057qib7 2264 21 of of IN cord-005453-4057qib7 2264 22 TBI TBI NNP cord-005453-4057qib7 2264 23 in in IN cord-005453-4057qib7 2264 24 the the DT cord-005453-4057qib7 2264 25 myeloablative myeloablative JJ cord-005453-4057qib7 2264 26 preparation preparation NN cord-005453-4057qib7 2264 27 regimen regimen NN cord-005453-4057qib7 2264 28 compared compare VBN cord-005453-4057qib7 2264 29 with with IN cord-005453-4057qib7 2264 30 myeloablative myeloablative JJ cord-005453-4057qib7 2264 31 preparation preparation NN cord-005453-4057qib7 2264 32 regimen regimen NN cord-005453-4057qib7 2264 33 alone alone RB cord-005453-4057qib7 2264 34 did do VBD cord-005453-4057qib7 2264 35 not not RB cord-005453-4057qib7 2264 36 have have VB cord-005453-4057qib7 2264 37 a a DT cord-005453-4057qib7 2264 38 positive positive JJ cord-005453-4057qib7 2264 39 or or CC cord-005453-4057qib7 2264 40 negative negative JJ cord-005453-4057qib7 2264 41 effect effect NN cord-005453-4057qib7 2264 42 on on IN cord-005453-4057qib7 2264 43 overall overall JJ cord-005453-4057qib7 2264 44 survival survival NN cord-005453-4057qib7 2264 45 . . . cord-005453-4057qib7 2265 1 We -PRON- PRP cord-005453-4057qib7 2265 2 think think VBP cord-005453-4057qib7 2265 3 that that IN cord-005453-4057qib7 2265 4 if if IN cord-005453-4057qib7 2265 5 we -PRON- PRP cord-005453-4057qib7 2265 6 can can MD cord-005453-4057qib7 2265 7 prepare prepare VB cord-005453-4057qib7 2265 8 a a DT cord-005453-4057qib7 2265 9 good good JJ cord-005453-4057qib7 2265 10 VOD VOD NNP cord-005453-4057qib7 2265 11 prophylaxis prophylaxis NN cord-005453-4057qib7 2265 12 approches approches NN cord-005453-4057qib7 2265 13 , , , cord-005453-4057qib7 2265 14 we -PRON- PRP cord-005453-4057qib7 2265 15 can can MD cord-005453-4057qib7 2265 16 give give VB cord-005453-4057qib7 2265 17 up up RP cord-005453-4057qib7 2265 18 TBI TBI NNP cord-005453-4057qib7 2265 19 in in IN cord-005453-4057qib7 2265 20 future future NN cord-005453-4057qib7 2265 21 . . . cord-005453-4057qib7 2266 1 Disclosure disclosure NN cord-005453-4057qib7 2266 2 ( ( -LRB- cord-005453-4057qib7 2266 3 n=3 n=3 NN cord-005453-4057qib7 2266 4 ) ) -RRB- cord-005453-4057qib7 2266 5 . . . cord-005453-4057qib7 2267 1 For for IN cord-005453-4057qib7 2267 2 GVHD GVHD NNP cord-005453-4057qib7 2267 3 prophylaxis prophylaxis NN cord-005453-4057qib7 2267 4 , , , cord-005453-4057qib7 2267 5 cyclosporine cyclosporine JJ cord-005453-4057qib7 2267 6 A A NNP cord-005453-4057qib7 2267 7 was be VBD cord-005453-4057qib7 2267 8 given give VBN cord-005453-4057qib7 2267 9 either either CC cord-005453-4057qib7 2267 10 alone alone JJ cord-005453-4057qib7 2267 11 ( ( -LRB- cord-005453-4057qib7 2267 12 n=21 n=21 NNP cord-005453-4057qib7 2267 13 ) ) -RRB- cord-005453-4057qib7 2267 14 , , , cord-005453-4057qib7 2267 15 with with IN cord-005453-4057qib7 2267 16 MMF MMF NNP cord-005453-4057qib7 2267 17 ( ( -LRB- cord-005453-4057qib7 2267 18 n=13 n=13 NNP cord-005453-4057qib7 2267 19 ) ) -RRB- cord-005453-4057qib7 2267 20 or or CC cord-005453-4057qib7 2267 21 with with IN cord-005453-4057qib7 2267 22 methotrexate methotrexate NNP cord-005453-4057qib7 2267 23 ( ( -LRB- cord-005453-4057qib7 2267 24 n=1 n=1 NNP cord-005453-4057qib7 2267 25 ) ) -RRB- cord-005453-4057qib7 2267 26 . . . cord-005453-4057qib7 2268 1 The the DT cord-005453-4057qib7 2268 2 graft graft NN cord-005453-4057qib7 2268 3 source source NN cord-005453-4057qib7 2268 4 was be VBD cord-005453-4057qib7 2268 5 bone bone NN cord-005453-4057qib7 2268 6 marrow marrow NN cord-005453-4057qib7 2268 7 ( ( -LRB- cord-005453-4057qib7 2268 8 BM BM NNP cord-005453-4057qib7 2268 9 ) ) -RRB- cord-005453-4057qib7 2268 10 in in IN cord-005453-4057qib7 2268 11 most most JJS cord-005453-4057qib7 2268 12 cases case NNS cord-005453-4057qib7 2268 13 ( ( -LRB- cord-005453-4057qib7 2268 14 n=31 n=31 NNP cord-005453-4057qib7 2268 15 ) ) -RRB- cord-005453-4057qib7 2268 16 , , , cord-005453-4057qib7 2268 17 PBSC PBSC NNP cord-005453-4057qib7 2268 18 in in IN cord-005453-4057qib7 2268 19 seven seven CD cord-005453-4057qib7 2268 20 cases case NNS cord-005453-4057qib7 2268 21 , , , cord-005453-4057qib7 2268 22 matched match VBN cord-005453-4057qib7 2268 23 sibling sibling NN cord-005453-4057qib7 2268 24 cord cord NN cord-005453-4057qib7 2268 25 + + CC cord-005453-4057qib7 2268 26 BM bm NN cord-005453-4057qib7 2268 27 in in IN cord-005453-4057qib7 2268 28 two two CD cord-005453-4057qib7 2268 29 cases case NNS cord-005453-4057qib7 2268 30 and and CC cord-005453-4057qib7 2268 31 one one CD cord-005453-4057qib7 2268 32 matched match VBN cord-005453-4057qib7 2268 33 related related JJ cord-005453-4057qib7 2268 34 cord cord NN cord-005453-4057qib7 2268 35 . . . cord-005453-4057qib7 2269 1 Twentyfive Twentyfive NNP cord-005453-4057qib7 2269 2 of of IN cord-005453-4057qib7 2269 3 the the DT cord-005453-4057qib7 2269 4 donors donor NNS cord-005453-4057qib7 2269 5 were be VBD cord-005453-4057qib7 2269 6 family family NN cord-005453-4057qib7 2269 7 donors donor NNS cord-005453-4057qib7 2269 8 and and CC cord-005453-4057qib7 2269 9 ten ten CD cord-005453-4057qib7 2269 10 were be VBD cord-005453-4057qib7 2269 11 unrelated unrelated JJ cord-005453-4057qib7 2269 12 . . . cord-005453-4057qib7 2270 1 Twenty twenty CD cord-005453-4057qib7 2270 2 - - HYPH cord-005453-4057qib7 2270 3 nine nine CD cord-005453-4057qib7 2270 4 of of IN cord-005453-4057qib7 2270 5 the the DT cord-005453-4057qib7 2270 6 donors donor NNS cord-005453-4057qib7 2270 7 were be VBD cord-005453-4057qib7 2270 8 10/10 10/10 CD cord-005453-4057qib7 2270 9 HLA HLA NNP cord-005453-4057qib7 2270 10 matched match VBN cord-005453-4057qib7 2270 11 , , , cord-005453-4057qib7 2270 12 six six CD cord-005453-4057qib7 2270 13 were be VBD cord-005453-4057qib7 2270 14 9/10 9/10 CD cord-005453-4057qib7 2270 15 mismatched mismatched JJ cord-005453-4057qib7 2270 16 and and CC cord-005453-4057qib7 2270 17 one one CD cord-005453-4057qib7 2270 18 haploidentical haploidentical JJ cord-005453-4057qib7 2270 19 . . . cord-005453-4057qib7 2271 1 Four four CD cord-005453-4057qib7 2271 2 patients patient NNS cord-005453-4057qib7 2271 3 had have VBD cord-005453-4057qib7 2271 4 engraftment engraftment NN cord-005453-4057qib7 2271 5 failure failure NN cord-005453-4057qib7 2271 6 and and CC cord-005453-4057qib7 2271 7 required require VBD cord-005453-4057qib7 2271 8 a a DT cord-005453-4057qib7 2271 9 second second JJ cord-005453-4057qib7 2271 10 transplant transplant NN cord-005453-4057qib7 2271 11 , , , cord-005453-4057qib7 2271 12 two two CD cord-005453-4057qib7 2271 13 of of IN cord-005453-4057qib7 2271 14 them -PRON- PRP cord-005453-4057qib7 2271 15 were be VBD cord-005453-4057qib7 2271 16 re re VBN cord-005453-4057qib7 2271 17 - - VBN cord-005453-4057qib7 2271 18 transplanted transplant VBN cord-005453-4057qib7 2271 19 with with IN cord-005453-4057qib7 2271 20 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 2271 21 and and CC cord-005453-4057qib7 2271 22 TBI TBI NNP cord-005453-4057qib7 2271 23 , , , cord-005453-4057qib7 2271 24 one one CD cord-005453-4057qib7 2271 25 with with IN cord-005453-4057qib7 2271 26 fludarabine fludarabine NN cord-005453-4057qib7 2271 27 , , , cord-005453-4057qib7 2271 28 busulfan busulfan NN cord-005453-4057qib7 2271 29 and and CC cord-005453-4057qib7 2271 30 campath campath NN cord-005453-4057qib7 2271 31 , , , cord-005453-4057qib7 2271 32 and and CC cord-005453-4057qib7 2271 33 one one CD cord-005453-4057qib7 2271 34 with with IN cord-005453-4057qib7 2271 35 no no DT cord-005453-4057qib7 2271 36 conditioning conditioning NN cord-005453-4057qib7 2271 37 . . . cord-005453-4057qib7 2272 1 Thirty thirty CD cord-005453-4057qib7 2272 2 of of IN cord-005453-4057qib7 2272 3 the the DT cord-005453-4057qib7 2272 4 35 35 CD cord-005453-4057qib7 2272 5 patients patient NNS cord-005453-4057qib7 2272 6 are be VBP cord-005453-4057qib7 2272 7 alive alive JJ cord-005453-4057qib7 2272 8 ( ( -LRB- cord-005453-4057qib7 2272 9 86 86 CD cord-005453-4057qib7 2272 10 % % NN cord-005453-4057qib7 2272 11 ) ) -RRB- cord-005453-4057qib7 2272 12 . . . cord-005453-4057qib7 2273 1 Four four CD cord-005453-4057qib7 2273 2 patients patient NNS cord-005453-4057qib7 2273 3 died die VBD cord-005453-4057qib7 2273 4 of of IN cord-005453-4057qib7 2273 5 transplant transplant NN cord-005453-4057qib7 2273 6 complications complication NNS cord-005453-4057qib7 2273 7 and and CC cord-005453-4057qib7 2273 8 one one CD cord-005453-4057qib7 2273 9 died die VBD cord-005453-4057qib7 2273 10 of of IN cord-005453-4057qib7 2273 11 metastatic metastatic JJ cord-005453-4057qib7 2273 12 squamous squamous JJ cord-005453-4057qib7 2273 13 cell cell NN cord-005453-4057qib7 2273 14 carcinoma carcinoma NN cord-005453-4057qib7 2273 15 . . . cord-005453-4057qib7 2274 1 Eight eight CD cord-005453-4057qib7 2274 2 survivors survivor NNS cord-005453-4057qib7 2274 3 are be VBP cord-005453-4057qib7 2274 4 mixed mixed JJ cord-005453-4057qib7 2274 5 chimeras chimera NNS cord-005453-4057qib7 2274 6 ( ( -LRB- cord-005453-4057qib7 2274 7 81%-94 81%-94 CD cord-005453-4057qib7 2274 8 % % NN cord-005453-4057qib7 2274 9 donor donor NN cord-005453-4057qib7 2274 10 ) ) -RRB- cord-005453-4057qib7 2274 11 and and CC cord-005453-4057qib7 2274 12 are be VBP cord-005453-4057qib7 2274 13 all all DT cord-005453-4057qib7 2274 14 doing do VBG cord-005453-4057qib7 2274 15 well well RB cord-005453-4057qib7 2274 16 , , , cord-005453-4057qib7 2274 17 none none NN cord-005453-4057qib7 2274 18 of of IN cord-005453-4057qib7 2274 19 them -PRON- PRP cord-005453-4057qib7 2274 20 developed develop VBD cord-005453-4057qib7 2274 21 any any DT cord-005453-4057qib7 2274 22 GVHD GVHD NNP cord-005453-4057qib7 2274 23 . . . cord-005453-4057qib7 2275 1 Nine nine CD cord-005453-4057qib7 2275 2 patients patient NNS cord-005453-4057qib7 2275 3 developed develop VBD cord-005453-4057qib7 2275 4 acute acute JJ cord-005453-4057qib7 2275 5 GVHD GVHD NNP cord-005453-4057qib7 2275 6 , , , cord-005453-4057qib7 2275 7 four four CD cord-005453-4057qib7 2275 8 of of IN cord-005453-4057qib7 2275 9 them -PRON- PRP cord-005453-4057qib7 2275 10 with with IN cord-005453-4057qib7 2275 11 grade grade NN cord-005453-4057qib7 2275 12 3 3 CD cord-005453-4057qib7 2275 13 - - SYM cord-005453-4057qib7 2275 14 4 4 CD cord-005453-4057qib7 2275 15 . . . cord-005453-4057qib7 2276 1 Seven seven CD cord-005453-4057qib7 2276 2 of of IN cord-005453-4057qib7 2276 3 these these DT cord-005453-4057qib7 2276 4 patients patient NNS cord-005453-4057qib7 2276 5 later later RB cord-005453-4057qib7 2276 6 developed develop VBD cord-005453-4057qib7 2276 7 chronic chronic JJ cord-005453-4057qib7 2276 8 GVHD GVHD NNP cord-005453-4057qib7 2276 9 , , , cord-005453-4057qib7 2276 10 two two CD cord-005453-4057qib7 2276 11 of of IN cord-005453-4057qib7 2276 12 them -PRON- PRP cord-005453-4057qib7 2276 13 have have VBP cord-005453-4057qib7 2276 14 extensive extensive JJ cord-005453-4057qib7 2276 15 disease disease NN cord-005453-4057qib7 2276 16 . . . cord-005453-4057qib7 2277 1 Conclusions conclusion NNS cord-005453-4057qib7 2277 2 : : : cord-005453-4057qib7 2278 1 Our -PRON- PRP$ cord-005453-4057qib7 2278 2 results result NNS cord-005453-4057qib7 2278 3 show show VBP cord-005453-4057qib7 2278 4 a a DT cord-005453-4057qib7 2278 5 high high JJ cord-005453-4057qib7 2278 6 survival survival NN cord-005453-4057qib7 2278 7 rate rate NN cord-005453-4057qib7 2278 8 of of IN cord-005453-4057qib7 2278 9 86 86 CD cord-005453-4057qib7 2278 10 % % NN cord-005453-4057qib7 2278 11 , , , cord-005453-4057qib7 2278 12 with with IN cord-005453-4057qib7 2278 13 a a DT cord-005453-4057qib7 2278 14 low low JJ cord-005453-4057qib7 2278 15 rate rate NN cord-005453-4057qib7 2278 16 of of IN cord-005453-4057qib7 2278 17 engraftment engraftment NN cord-005453-4057qib7 2278 18 failure failure NN cord-005453-4057qib7 2278 19 and and CC cord-005453-4057qib7 2278 20 reasonable reasonable JJ cord-005453-4057qib7 2278 21 rates rate NNS cord-005453-4057qib7 2278 22 of of IN cord-005453-4057qib7 2278 23 GVHD GVHD NNP cord-005453-4057qib7 2278 24 . . . cord-005453-4057qib7 2279 1 Only only RB cord-005453-4057qib7 2279 2 one one CD cord-005453-4057qib7 2279 3 of of IN cord-005453-4057qib7 2279 4 our -PRON- PRP$ cord-005453-4057qib7 2279 5 patients patient NNS cord-005453-4057qib7 2279 6 died die VBD cord-005453-4057qib7 2279 7 of of IN cord-005453-4057qib7 2279 8 late late JJ cord-005453-4057qib7 2279 9 effects effect NNS cord-005453-4057qib7 2279 10 of of IN cord-005453-4057qib7 2279 11 HSCT HSCT NNP cord-005453-4057qib7 2279 12 for for IN cord-005453-4057qib7 2279 13 FA FA NNP cord-005453-4057qib7 2279 14 . . . cord-005453-4057qib7 2280 1 Mixed mixed JJ cord-005453-4057qib7 2280 2 chimerism chimerism NN cord-005453-4057qib7 2280 3 does do VBZ cord-005453-4057qib7 2280 4 not not RB cord-005453-4057qib7 2280 5 seem seem VB cord-005453-4057qib7 2280 6 to to TO cord-005453-4057qib7 2280 7 present present VB cord-005453-4057qib7 2280 8 a a DT cord-005453-4057qib7 2280 9 problem problem NN cord-005453-4057qib7 2280 10 . . . cord-005453-4057qib7 2281 1 We -PRON- PRP cord-005453-4057qib7 2281 2 conclude conclude VBP cord-005453-4057qib7 2281 3 that that IN cord-005453-4057qib7 2281 4 reduced reduce VBN cord-005453-4057qib7 2281 5 intensity intensity NN cord-005453-4057qib7 2281 6 fludarabine fludarabine NN cord-005453-4057qib7 2281 7 based base VBN cord-005453-4057qib7 2281 8 conditioning conditioning NN cord-005453-4057qib7 2281 9 regimens regimen NNS cord-005453-4057qib7 2281 10 are be VBP cord-005453-4057qib7 2281 11 a a DT cord-005453-4057qib7 2281 12 good good JJ cord-005453-4057qib7 2281 13 treatment treatment NN cord-005453-4057qib7 2281 14 option option NN cord-005453-4057qib7 2281 15 for for IN cord-005453-4057qib7 2281 16 patients patient NNS cord-005453-4057qib7 2281 17 with with IN cord-005453-4057qib7 2281 18 Fanconi Fanconi NNP cord-005453-4057qib7 2281 19 anemia anemia NN cord-005453-4057qib7 2281 20 undergoing undergo VBG cord-005453-4057qib7 2281 21 HSCT HSCT NNP cord-005453-4057qib7 2281 22 . . . cord-005453-4057qib7 2282 1 Disclosure disclosure NN cord-005453-4057qib7 2282 2 : : : cord-005453-4057qib7 2282 3 Nothing nothing NN cord-005453-4057qib7 2282 4 to to TO cord-005453-4057qib7 2282 5 declare declare VB cord-005453-4057qib7 2282 6 Total total JJ cord-005453-4057qib7 2282 7 marrow marrow NN cord-005453-4057qib7 2282 8 irradiation irradiation NN cord-005453-4057qib7 2282 9 + + CC cord-005453-4057qib7 2282 10 bendamustine bendamustine NN cord-005453-4057qib7 2282 11 as as IN cord-005453-4057qib7 2282 12 reducedtoxicity reducedtoxicity NNP cord-005453-4057qib7 2282 13 myeloablative myeloablative NNP cord-005453-4057qib7 2282 14 conditioning conditioning NN cord-005453-4057qib7 2282 15 prior prior RB cord-005453-4057qib7 2282 16 to to IN cord-005453-4057qib7 2282 17 allohsct allohsct NNP cord-005453-4057qib7 2282 18 for for IN cord-005453-4057qib7 2282 19 younger young JJR cord-005453-4057qib7 2282 20 patients patient NNS cord-005453-4057qib7 2282 21 with with IN cord-005453-4057qib7 2282 22 multiple multiple JJ cord-005453-4057qib7 2282 23 myeloma myeloma NN cord-005453-4057qib7 2282 24 Background background NN cord-005453-4057qib7 2282 25 : : : cord-005453-4057qib7 2283 1 The the DT cord-005453-4057qib7 2283 2 prognosis prognosis NN cord-005453-4057qib7 2283 3 of of IN cord-005453-4057qib7 2283 4 patients patient NNS cord-005453-4057qib7 2283 5 with with IN cord-005453-4057qib7 2283 6 multiple multiple JJ cord-005453-4057qib7 2283 7 myeloma myeloma NN cord-005453-4057qib7 2283 8 ( ( -LRB- cord-005453-4057qib7 2283 9 MM MM NNP cord-005453-4057qib7 2283 10 ) ) -RRB- cord-005453-4057qib7 2283 11 has have VBZ cord-005453-4057qib7 2283 12 improved improve VBN cord-005453-4057qib7 2283 13 markedly markedly RB cord-005453-4057qib7 2283 14 over over IN cord-005453-4057qib7 2283 15 the the DT cord-005453-4057qib7 2283 16 last last JJ cord-005453-4057qib7 2283 17 two two CD cord-005453-4057qib7 2283 18 decades decade NNS cord-005453-4057qib7 2283 19 . . . cord-005453-4057qib7 2284 1 Despite despite IN cord-005453-4057qib7 2284 2 that that DT cord-005453-4057qib7 2284 3 , , , cord-005453-4057qib7 2284 4 alloHSCT alloHSCT NNP cord-005453-4057qib7 2284 5 remains remain VBZ cord-005453-4057qib7 2284 6 the the DT cord-005453-4057qib7 2284 7 only only JJ cord-005453-4057qib7 2284 8 treatment treatment NN cord-005453-4057qib7 2284 9 option option NN cord-005453-4057qib7 2284 10 with with IN cord-005453-4057qib7 2284 11 curative curative JJ cord-005453-4057qib7 2284 12 potential potential NN cord-005453-4057qib7 2284 13 . . . cord-005453-4057qib7 2285 1 However however RB cord-005453-4057qib7 2285 2 , , , cord-005453-4057qib7 2285 3 its -PRON- PRP$ cord-005453-4057qib7 2285 4 use use NN cord-005453-4057qib7 2285 5 is be VBZ cord-005453-4057qib7 2285 6 limited limit VBN cord-005453-4057qib7 2285 7 due due IN cord-005453-4057qib7 2285 8 to to IN cord-005453-4057qib7 2285 9 high high JJ cord-005453-4057qib7 2285 10 incidence incidence NN cord-005453-4057qib7 2285 11 of of IN cord-005453-4057qib7 2285 12 non non JJ cord-005453-4057qib7 2285 13 - - JJ cord-005453-4057qib7 2285 14 relapse relapse JJ cord-005453-4057qib7 2285 15 mortality mortality NN cord-005453-4057qib7 2285 16 ( ( -LRB- cord-005453-4057qib7 2285 17 NRM NRM NNP cord-005453-4057qib7 2285 18 ) ) -RRB- cord-005453-4057qib7 2285 19 after after IN cord-005453-4057qib7 2285 20 myeloablative myeloablative NNP cord-005453-4057qib7 2285 21 conditioning conditioning NN cord-005453-4057qib7 2285 22 while while IN cord-005453-4057qib7 2285 23 insufficient insufficient JJ cord-005453-4057qib7 2285 24 efficacy efficacy NN cord-005453-4057qib7 2285 25 of of IN cord-005453-4057qib7 2285 26 reduced reduce VBN cord-005453-4057qib7 2285 27 - - HYPH cord-005453-4057qib7 2285 28 intensity intensity NN cord-005453-4057qib7 2285 29 regimens regimen NNS cord-005453-4057qib7 2285 30 . . . cord-005453-4057qib7 2286 1 We -PRON- PRP cord-005453-4057qib7 2286 2 developed develop VBD cord-005453-4057qib7 2286 3 a a DT cord-005453-4057qib7 2286 4 new new JJ cord-005453-4057qib7 2286 5 protocol protocol NN cord-005453-4057qib7 2286 6 characterized characterize VBN cord-005453-4057qib7 2286 7 by by IN cord-005453-4057qib7 2286 8 reduced reduce VBN cord-005453-4057qib7 2286 9 toxicity toxicity NN cord-005453-4057qib7 2286 10 while while IN cord-005453-4057qib7 2286 11 preserved preserve VBD cord-005453-4057qib7 2286 12 myeloablative myeloablative JJ cord-005453-4057qib7 2286 13 potential potential NN cord-005453-4057qib7 2286 14 , , , cord-005453-4057qib7 2286 15 based base VBN cord-005453-4057qib7 2286 16 on on IN cord-005453-4057qib7 2286 17 the the DT cord-005453-4057qib7 2286 18 use use NN cord-005453-4057qib7 2286 19 of of IN cord-005453-4057qib7 2286 20 total total JJ cord-005453-4057qib7 2286 21 marrow marrow NN cord-005453-4057qib7 2286 22 irradiation irradiation NN cord-005453-4057qib7 2286 23 ( ( -LRB- cord-005453-4057qib7 2286 24 TMI TMI NNP cord-005453-4057qib7 2286 25 ) ) -RRB- cord-005453-4057qib7 2286 26 in in IN cord-005453-4057qib7 2286 27 combination combination NN cord-005453-4057qib7 2286 28 with with IN cord-005453-4057qib7 2286 29 bendamustine bendamustine NNP cord-005453-4057qib7 2286 30 . . . cord-005453-4057qib7 2287 1 The the DT cord-005453-4057qib7 2287 2 aim aim NN cord-005453-4057qib7 2287 3 of of IN cord-005453-4057qib7 2287 4 this this DT cord-005453-4057qib7 2287 5 study study NN cord-005453-4057qib7 2287 6 was be VBD cord-005453-4057qib7 2287 7 to to TO cord-005453-4057qib7 2287 8 evaluate evaluate VB cord-005453-4057qib7 2287 9 its -PRON- PRP$ cord-005453-4057qib7 2287 10 safety safety NN cord-005453-4057qib7 2287 11 and and CC cord-005453-4057qib7 2287 12 efficacy efficacy NN cord-005453-4057qib7 2287 13 in in IN cord-005453-4057qib7 2287 14 a a DT cord-005453-4057qib7 2287 15 singlecenter singlecenter JJ cord-005453-4057qib7 2287 16 experience experience NN cord-005453-4057qib7 2287 17 . . . cord-005453-4057qib7 2288 1 Methods method NNS cord-005453-4057qib7 2288 2 : : : cord-005453-4057qib7 2288 3 Between between IN cord-005453-4057qib7 2288 4 years year NNS cord-005453-4057qib7 2288 5 2013 2013 CD cord-005453-4057qib7 2288 6 - - SYM cord-005453-4057qib7 2288 7 2018 2018 CD cord-005453-4057qib7 2288 8 , , , cord-005453-4057qib7 2288 9 MM MM NNP cord-005453-4057qib7 2288 10 patients patient NNS cord-005453-4057qib7 2288 11 below below IN cord-005453-4057qib7 2288 12 55 55 CD cord-005453-4057qib7 2288 13 years year NNS cord-005453-4057qib7 2288 14 old old JJ cord-005453-4057qib7 2288 15 were be VBD cord-005453-4057qib7 2288 16 offered offer VBN cord-005453-4057qib7 2288 17 tandem tandem JJ cord-005453-4057qib7 2288 18 auto auto NN cord-005453-4057qib7 2288 19 - - HYPH cord-005453-4057qib7 2288 20 alloHSCT allohsct NN cord-005453-4057qib7 2288 21 as as IN cord-005453-4057qib7 2288 22 part part NN cord-005453-4057qib7 2288 23 of of IN cord-005453-4057qib7 2288 24 first first JJ cord-005453-4057qib7 2288 25 - - HYPH cord-005453-4057qib7 2288 26 line line NN cord-005453-4057qib7 2288 27 therapy therapy NN cord-005453-4057qib7 2288 28 . . . cord-005453-4057qib7 2289 1 The the DT cord-005453-4057qib7 2289 2 decision decision NN cord-005453-4057qib7 2289 3 was be VBD cord-005453-4057qib7 2289 4 based base VBN cord-005453-4057qib7 2289 5 on on IN cord-005453-4057qib7 2289 6 individual individual JJ cord-005453-4057qib7 2289 7 patient patient NN cord-005453-4057qib7 2289 8 preferences preference NNS cord-005453-4057qib7 2289 9 after after IN cord-005453-4057qib7 2289 10 detailed detailed JJ cord-005453-4057qib7 2289 11 description description NN cord-005453-4057qib7 2289 12 of of IN cord-005453-4057qib7 2289 13 potential potential JJ cord-005453-4057qib7 2289 14 risks risk NNS cord-005453-4057qib7 2289 15 . . . cord-005453-4057qib7 2290 1 AutoHSCT AutoHSCT NNP cord-005453-4057qib7 2290 2 was be VBD cord-005453-4057qib7 2290 3 preceded precede VBN cord-005453-4057qib7 2290 4 by by IN cord-005453-4057qib7 2290 5 melphalan melphalan NNP cord-005453-4057qib7 2291 1 200 200 CD cord-005453-4057qib7 2291 2 mg mg NNP cord-005453-4057qib7 2291 3 / / SYM cord-005453-4057qib7 2291 4 m m NNP cord-005453-4057qib7 2291 5 2 2 CD cord-005453-4057qib7 2291 6 iv iv CD cord-005453-4057qib7 2291 7 . . . cord-005453-4057qib7 2292 1 The the DT cord-005453-4057qib7 2292 2 conditioning conditioning NN cord-005453-4057qib7 2292 3 prior prior RB cord-005453-4057qib7 2292 4 to to IN cord-005453-4057qib7 2292 5 alloHSCT alloHSCT NNP cord-005453-4057qib7 2292 6 consisted consisted NNP cord-005453-4057qib7 2292 7 of of IN cord-005453-4057qib7 2292 8 TMI TMI NNP cord-005453-4057qib7 2292 9 performed perform VBN cord-005453-4057qib7 2292 10 using use VBG cord-005453-4057qib7 2292 11 helical helical JJ cord-005453-4057qib7 2292 12 tomotherapy tomotherapy NN cord-005453-4057qib7 2292 13 at at IN cord-005453-4057qib7 2292 14 the the DT cord-005453-4057qib7 2292 15 dose dose NN cord-005453-4057qib7 2292 16 of of IN cord-005453-4057qib7 2292 17 4 4 CD cord-005453-4057qib7 2292 18 Gy Gy NNP cord-005453-4057qib7 2292 19 / / SYM cord-005453-4057qib7 2292 20 d d NN cord-005453-4057qib7 2292 21 on on IN cord-005453-4057qib7 2292 22 days day NNS cord-005453-4057qib7 2292 23 -3 -3 NNP cord-005453-4057qib7 2292 24 , , , cord-005453-4057qib7 2292 25 -2 -2 NNP cord-005453-4057qib7 2292 26 , , , cord-005453-4057qib7 2292 27 -1 -1 NNP cord-005453-4057qib7 2292 28 ( ( -LRB- cord-005453-4057qib7 2292 29 total total JJ cord-005453-4057qib7 2292 30 12 12 CD cord-005453-4057qib7 2292 31 Gy Gy NNP cord-005453-4057qib7 2292 32 ) ) -RRB- cord-005453-4057qib7 2292 33 and and CC cord-005453-4057qib7 2292 34 bendamustine bendamustine NNP cord-005453-4057qib7 2292 35 140 140 CD cord-005453-4057qib7 2292 36 - - SYM cord-005453-4057qib7 2292 37 220 220 CD cord-005453-4057qib7 2292 38 mg mg NNP cord-005453-4057qib7 2292 39 / / SYM cord-005453-4057qib7 2292 40 m2 m2 NNP cord-005453-4057qib7 2292 41 / / SYM cord-005453-4057qib7 2292 42 d d NNP cord-005453-4057qib7 2293 1 iv iv LS cord-005453-4057qib7 2293 2 . . . cord-005453-4057qib7 2294 1 on on IN cord-005453-4057qib7 2294 2 days day NNS cord-005453-4057qib7 2294 3 -5 -5 NNP cord-005453-4057qib7 2294 4 , , , cord-005453-4057qib7 2294 5 -4 -4 NNP cord-005453-4057qib7 2294 6 ( ( -LRB- cord-005453-4057qib7 2294 7 total total JJ cord-005453-4057qib7 2294 8 280 280 CD cord-005453-4057qib7 2294 9 - - SYM cord-005453-4057qib7 2294 10 440 440 CD cord-005453-4057qib7 2294 11 mg mg NNP cord-005453-4057qib7 2294 12 / / SYM cord-005453-4057qib7 2294 13 m2 m2 NNP cord-005453-4057qib7 2294 14 ) ) -RRB- cord-005453-4057qib7 2294 15 . . . cord-005453-4057qib7 2295 1 The the DT cord-005453-4057qib7 2295 2 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 2295 3 therapy therapy NN cord-005453-4057qib7 2295 4 consisted consist VBD cord-005453-4057qib7 2295 5 of of IN cord-005453-4057qib7 2295 6 cyclosporine cyclosporine NN cord-005453-4057qib7 2295 7 + + CC cord-005453-4057qib7 2295 8 methotrexate methotrexate NN cord-005453-4057qib7 2295 9 + + . cord-005453-4057qib7 2296 1 /-ATG /-ATG NNP cord-005453-4057qib7 2296 2 . . . cord-005453-4057qib7 2297 1 Peripheral peripheral JJ cord-005453-4057qib7 2297 2 blood blood NN cord-005453-4057qib7 2297 3 was be VBD cord-005453-4057qib7 2297 4 used use VBN cord-005453-4057qib7 2297 5 as as IN cord-005453-4057qib7 2297 6 a a DT cord-005453-4057qib7 2297 7 source source NN cord-005453-4057qib7 2297 8 of of IN cord-005453-4057qib7 2297 9 stem stem NN cord-005453-4057qib7 2297 10 cells cell NNS cord-005453-4057qib7 2297 11 . . . cord-005453-4057qib7 2298 1 Results result NNS cord-005453-4057qib7 2298 2 : : : cord-005453-4057qib7 2299 1 The the DT cord-005453-4057qib7 2299 2 analysis analysis NN cord-005453-4057qib7 2299 3 included include VBD cord-005453-4057qib7 2299 4 18 18 CD cord-005453-4057qib7 2299 5 patients patient NNS cord-005453-4057qib7 2299 6 ( ( -LRB- cord-005453-4057qib7 2299 7 women woman NNS cord-005453-4057qib7 2299 8 -9 -9 ADD cord-005453-4057qib7 2299 9 , , , cord-005453-4057qib7 2299 10 men man NNS cord-005453-4057qib7 2299 11 -9 -9 ADD cord-005453-4057qib7 2299 12 ) ) -RRB- cord-005453-4057qib7 2299 13 . . . cord-005453-4057qib7 2300 1 The the DT cord-005453-4057qib7 2300 2 median median JJ cord-005453-4057qib7 2300 3 follow follow NN cord-005453-4057qib7 2300 4 - - HYPH cord-005453-4057qib7 2300 5 up up NN cord-005453-4057qib7 2300 6 was be VBD cord-005453-4057qib7 2300 7 28 28 CD cord-005453-4057qib7 2300 8 ( ( -LRB- cord-005453-4057qib7 2300 9 4 4 CD cord-005453-4057qib7 2300 10 - - SYM cord-005453-4057qib7 2300 11 68 68 CD cord-005453-4057qib7 2300 12 ) ) -RRB- cord-005453-4057qib7 2300 13 months month NNS cord-005453-4057qib7 2300 14 . . . cord-005453-4057qib7 2301 1 The the DT cord-005453-4057qib7 2301 2 median median JJ cord-005453-4057qib7 2301 3 age age NN cord-005453-4057qib7 2301 4 at at IN cord-005453-4057qib7 2301 5 alloHSCT alloHSCT NNP cord-005453-4057qib7 2301 6 was be VBD cord-005453-4057qib7 2301 7 44 44 CD cord-005453-4057qib7 2301 8 ( ( -LRB- cord-005453-4057qib7 2301 9 26 26 CD cord-005453-4057qib7 2301 10 -53 -53 NNP cord-005453-4057qib7 2301 11 ) ) -RRB- cord-005453-4057qib7 2301 12 years year NNS cord-005453-4057qib7 2301 13 . . . cord-005453-4057qib7 2302 1 The the DT cord-005453-4057qib7 2302 2 disease disease NN cord-005453-4057qib7 2302 3 stage stage NN cord-005453-4057qib7 2302 4 before before IN cord-005453-4057qib7 2302 5 alloHSCT alloHSCT NNP cord-005453-4057qib7 2302 6 was be VBD cord-005453-4057qib7 2302 7 as as IN cord-005453-4057qib7 2302 8 follows follow VBZ cord-005453-4057qib7 2302 9 : : : cord-005453-4057qib7 2303 1 CR-6 CR-6 NNP cord-005453-4057qib7 2303 2 , , , cord-005453-4057qib7 2303 3 VGPR-4 VGPR-4 NNP cord-005453-4057qib7 2303 4 , , , cord-005453-4057qib7 2303 5 PR-6 PR-6 NNP cord-005453-4057qib7 2303 6 . . . cord-005453-4057qib7 2304 1 Patients patient NNS cord-005453-4057qib7 2304 2 were be VBD cord-005453-4057qib7 2304 3 treated treat VBN cord-005453-4057qib7 2304 4 with with IN cord-005453-4057qib7 2304 5 HSCT HSCT NNP cord-005453-4057qib7 2304 6 from from IN cord-005453-4057qib7 2304 7 either either CC cord-005453-4057qib7 2304 8 HLAmatched hlamatche VBN cord-005453-4057qib7 2304 9 siblings sibling NNS cord-005453-4057qib7 2304 10 ( ( -LRB- cord-005453-4057qib7 2304 11 n=7 n=7 NNS cord-005453-4057qib7 2304 12 ) ) -RRB- cord-005453-4057qib7 2304 13 or or CC cord-005453-4057qib7 2304 14 unrelated unrelated JJ cord-005453-4057qib7 2304 15 donors donor NNS cord-005453-4057qib7 2304 16 ( ( -LRB- cord-005453-4057qib7 2304 17 n=11 n=11 NNP cord-005453-4057qib7 2304 18 ) ) -RRB- cord-005453-4057qib7 2304 19 . . . cord-005453-4057qib7 2305 1 The the DT cord-005453-4057qib7 2305 2 interval interval NN cord-005453-4057qib7 2305 3 between between IN cord-005453-4057qib7 2305 4 autoHSCT autohsct NN cord-005453-4057qib7 2305 5 and and CC cord-005453-4057qib7 2305 6 alloHSCT alloHSCT NNP cord-005453-4057qib7 2305 7 was be VBD cord-005453-4057qib7 2305 8 5 5 CD cord-005453-4057qib7 2305 9 ( ( -LRB- cord-005453-4057qib7 2305 10 4 4 CD cord-005453-4057qib7 2305 11 - - SYM cord-005453-4057qib7 2305 12 23 23 CD cord-005453-4057qib7 2305 13 ) ) -RRB- cord-005453-4057qib7 2305 14 months month NNS cord-005453-4057qib7 2305 15 . . . cord-005453-4057qib7 2306 1 All all DT cord-005453-4057qib7 2306 2 patients patient NNS cord-005453-4057qib7 2306 3 engrafted engraft VBN cord-005453-4057qib7 2306 4 after after IN cord-005453-4057qib7 2306 5 alloHSCT alloHSCT NNP cord-005453-4057qib7 2306 6 with with IN cord-005453-4057qib7 2306 7 median median JJ cord-005453-4057qib7 2306 8 time time NN cord-005453-4057qib7 2306 9 of of IN cord-005453-4057qib7 2306 10 neutrophil neutrophil NN cord-005453-4057qib7 2306 11 and and CC cord-005453-4057qib7 2306 12 platelet platelet NN cord-005453-4057qib7 2306 13 recovery recovery NN cord-005453-4057qib7 2306 14 of of IN cord-005453-4057qib7 2306 15 14 14 CD cord-005453-4057qib7 2306 16 and and CC cord-005453-4057qib7 2306 17 12 12 CD cord-005453-4057qib7 2306 18 days day NNS cord-005453-4057qib7 2306 19 , , , cord-005453-4057qib7 2306 20 respectively respectively RB cord-005453-4057qib7 2306 21 . . . cord-005453-4057qib7 2307 1 One one CD cord-005453-4057qib7 2307 2 patient patient NN cord-005453-4057qib7 2307 3 ( ( -LRB- cord-005453-4057qib7 2307 4 6 6 CD cord-005453-4057qib7 2307 5 % % NN cord-005453-4057qib7 2307 6 ) ) -RRB- cord-005453-4057qib7 2307 7 experienced experienced JJ cord-005453-4057qib7 2307 8 grade grade NN cord-005453-4057qib7 2307 9 2 2 CD cord-005453-4057qib7 2307 10 acute acute JJ cord-005453-4057qib7 2307 11 GvHD gvhd NN cord-005453-4057qib7 2307 12 , , , cord-005453-4057qib7 2307 13 while while IN cord-005453-4057qib7 2307 14 there there EX cord-005453-4057qib7 2307 15 were be VBD cord-005453-4057qib7 2307 16 no no DT cord-005453-4057qib7 2307 17 cases case NNS cord-005453-4057qib7 2307 18 of of IN cord-005453-4057qib7 2307 19 grade grade NN cord-005453-4057qib7 2307 20 3 3 CD cord-005453-4057qib7 2307 21 - - SYM cord-005453-4057qib7 2307 22 4 4 CD cord-005453-4057qib7 2307 23 acute acute JJ cord-005453-4057qib7 2307 24 GvHD GvHD NNP cord-005453-4057qib7 2307 25 . . . cord-005453-4057qib7 2308 1 The the DT cord-005453-4057qib7 2308 2 incidence incidence NN cord-005453-4057qib7 2308 3 of of IN cord-005453-4057qib7 2308 4 mild mild JJ cord-005453-4057qib7 2308 5 , , , cord-005453-4057qib7 2308 6 moderate moderate JJ cord-005453-4057qib7 2308 7 and and CC cord-005453-4057qib7 2308 8 severe severe JJ cord-005453-4057qib7 2308 9 chronic chronic JJ cord-005453-4057qib7 2308 10 GvHD gvhd NN cord-005453-4057qib7 2308 11 was be VBD cord-005453-4057qib7 2308 12 17 17 CD cord-005453-4057qib7 2308 13 % % NN cord-005453-4057qib7 2308 14 , , , cord-005453-4057qib7 2308 15 0 0 CD cord-005453-4057qib7 2308 16 % % NN cord-005453-4057qib7 2308 17 and and CC cord-005453-4057qib7 2308 18 6 6 CD cord-005453-4057qib7 2308 19 % % NN cord-005453-4057qib7 2308 20 , , , cord-005453-4057qib7 2308 21 respectively respectively RB cord-005453-4057qib7 2308 22 . . . cord-005453-4057qib7 2309 1 The the DT cord-005453-4057qib7 2309 2 rate rate NN cord-005453-4057qib7 2309 3 of of IN cord-005453-4057qib7 2309 4 grade grade NN cord-005453-4057qib7 2309 5 3 3 CD cord-005453-4057qib7 2309 6 non non JJ cord-005453-4057qib7 2309 7 - - JJ cord-005453-4057qib7 2309 8 hematological hematological JJ cord-005453-4057qib7 2309 9 toxicities toxicity NNS cord-005453-4057qib7 2309 10 was be VBD cord-005453-4057qib7 2309 11 11 11 CD cord-005453-4057qib7 2309 12 % % NN cord-005453-4057qib7 2309 13 . . . cord-005453-4057qib7 2310 1 One one CD cord-005453-4057qib7 2310 2 patient patient NN cord-005453-4057qib7 2310 3 died die VBD cord-005453-4057qib7 2310 4 of of IN cord-005453-4057qib7 2310 5 late late JJ cord-005453-4057qib7 2310 6 bacterial bacterial JJ cord-005453-4057qib7 2310 7 infection infection NN cord-005453-4057qib7 2310 8 . . . cord-005453-4057qib7 2311 1 The the DT cord-005453-4057qib7 2311 2 incidence incidence NN cord-005453-4057qib7 2311 3 of of IN cord-005453-4057qib7 2311 4 TRM TRM NNP cord-005453-4057qib7 2311 5 was be VBD cord-005453-4057qib7 2311 6 5 5 CD cord-005453-4057qib7 2311 7 % % NN cord-005453-4057qib7 2311 8 . . . cord-005453-4057qib7 2312 1 Grade grade NN cord-005453-4057qib7 2312 2 4 4 CD cord-005453-4057qib7 2312 3 adverse adverse JJ cord-005453-4057qib7 2312 4 events event NNS cord-005453-4057qib7 2312 5 were be VBD cord-005453-4057qib7 2312 6 not not RB cord-005453-4057qib7 2312 7 reported report VBN cord-005453-4057qib7 2312 8 . . . cord-005453-4057qib7 2313 1 Disease disease NN cord-005453-4057qib7 2313 2 status status NN cord-005453-4057qib7 2313 3 3 3 CD cord-005453-4057qib7 2313 4 months month NNS cord-005453-4057qib7 2313 5 after after IN cord-005453-4057qib7 2313 6 alloHSCT alloHSCT NNP cord-005453-4057qib7 2313 7 was be VBD cord-005453-4057qib7 2313 8 : : : cord-005453-4057qib7 2314 1 CR-10 CR-10 NNP cord-005453-4057qib7 2314 2 , , , cord-005453-4057qib7 2314 3 VGPR-5 VGPR-5 NNP cord-005453-4057qib7 2314 4 , , , cord-005453-4057qib7 2314 5 PR-3 PR-3 NNP cord-005453-4057qib7 2314 6 . . . cord-005453-4057qib7 2315 1 The the DT cord-005453-4057qib7 2315 2 probability probability NN cord-005453-4057qib7 2315 3 of of IN cord-005453-4057qib7 2315 4 OS OS NNP cord-005453-4057qib7 2315 5 and and CC cord-005453-4057qib7 2315 6 PFS PFS NNP cord-005453-4057qib7 2315 7 after after IN cord-005453-4057qib7 2315 8 30 30 CD cord-005453-4057qib7 2315 9 months month NNS cord-005453-4057qib7 2315 10 was be VBD cord-005453-4057qib7 2315 11 94 94 CD cord-005453-4057qib7 2315 12 % % NN cord-005453-4057qib7 2315 13 ( ( -LRB- cord-005453-4057qib7 2315 14 + + CC cord-005453-4057qib7 2315 15 /-6 /-6 CD cord-005453-4057qib7 2315 16 % % NN cord-005453-4057qib7 2315 17 ) ) -RRB- cord-005453-4057qib7 2315 18 and and CC cord-005453-4057qib7 2315 19 77 77 CD cord-005453-4057qib7 2315 20 % % NN cord-005453-4057qib7 2315 21 ( ( -LRB- cord-005453-4057qib7 2315 22 + + CC cord-005453-4057qib7 2315 23 /-12 /-12 . cord-005453-4057qib7 2315 24 % % NN cord-005453-4057qib7 2315 25 ) ) -RRB- cord-005453-4057qib7 2315 26 , , , cord-005453-4057qib7 2315 27 respectively respectively RB cord-005453-4057qib7 2315 28 . . . cord-005453-4057qib7 2316 1 The the DT cord-005453-4057qib7 2316 2 incidence incidence NN cord-005453-4057qib7 2316 3 of of IN cord-005453-4057qib7 2316 4 progression progression NN cord-005453-4057qib7 2316 5 and and CC cord-005453-4057qib7 2316 6 TRM TRM NNP cord-005453-4057qib7 2316 7 was be VBD cord-005453-4057qib7 2316 8 17 17 CD cord-005453-4057qib7 2316 9 % % NN cord-005453-4057qib7 2316 10 and and CC cord-005453-4057qib7 2316 11 6 6 CD cord-005453-4057qib7 2316 12 % % NN cord-005453-4057qib7 2316 13 , , , cord-005453-4057qib7 2316 14 respectively respectively RB cord-005453-4057qib7 2316 15 . . . cord-005453-4057qib7 2317 1 Conclusions conclusion NNS cord-005453-4057qib7 2317 2 : : : cord-005453-4057qib7 2318 1 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 2319 1 using use VBG cord-005453-4057qib7 2319 2 TMI TMI NNP cord-005453-4057qib7 2319 3 12Gy 12gy CD cord-005453-4057qib7 2319 4 + + CC cord-005453-4057qib7 2319 5 bendamustine bendamustine NNP cord-005453-4057qib7 2319 6 conditioning conditioning NN cord-005453-4057qib7 2319 7 protocol protocol NN cord-005453-4057qib7 2319 8 is be VBZ cord-005453-4057qib7 2319 9 characterized characterize VBN cord-005453-4057qib7 2319 10 by by IN cord-005453-4057qib7 2319 11 good good JJ cord-005453-4057qib7 2319 12 tolerance tolerance NN cord-005453-4057qib7 2319 13 and and CC cord-005453-4057qib7 2319 14 low low JJ cord-005453-4057qib7 2319 15 risk risk NN cord-005453-4057qib7 2319 16 of of IN cord-005453-4057qib7 2319 17 GvHD GvHD NNP cord-005453-4057qib7 2319 18 . . . cord-005453-4057qib7 2320 1 It -PRON- PRP cord-005453-4057qib7 2320 2 may may MD cord-005453-4057qib7 2320 3 be be VB cord-005453-4057qib7 2320 4 used use VBN cord-005453-4057qib7 2320 5 for for IN cord-005453-4057qib7 2320 6 younger young JJR cord-005453-4057qib7 2320 7 patients patient NNS cord-005453-4057qib7 2320 8 with with IN cord-005453-4057qib7 2320 9 MM MM NNP cord-005453-4057qib7 2320 10 as as IN cord-005453-4057qib7 2320 11 part part NN cord-005453-4057qib7 2320 12 of of IN cord-005453-4057qib7 2320 13 tandem tandem JJ cord-005453-4057qib7 2320 14 auto auto NN cord-005453-4057qib7 2320 15 - - HYPH cord-005453-4057qib7 2320 16 alloHSCT allohsct NN cord-005453-4057qib7 2320 17 strategy strategy NN cord-005453-4057qib7 2320 18 . . . cord-005453-4057qib7 2321 1 Encouraging encourage VBG cord-005453-4057qib7 2321 2 results result NNS cord-005453-4057qib7 2321 3 reported report VBN cord-005453-4057qib7 2321 4 in in IN cord-005453-4057qib7 2321 5 this this DT cord-005453-4057qib7 2321 6 study study NN cord-005453-4057qib7 2321 7 should should MD cord-005453-4057qib7 2321 8 be be VB cord-005453-4057qib7 2321 9 confirmed confirm VBN cord-005453-4057qib7 2321 10 in in IN cord-005453-4057qib7 2321 11 prospective prospective JJ cord-005453-4057qib7 2321 12 clinical clinical JJ cord-005453-4057qib7 2321 13 trials trial NNS cord-005453-4057qib7 2321 14 . . . cord-005453-4057qib7 2322 1 Disclosure disclosure NN cord-005453-4057qib7 2322 2 : : : cord-005453-4057qib7 2322 3 Nothing nothing NN cord-005453-4057qib7 2322 4 to to TO cord-005453-4057qib7 2322 5 declare declare VB cord-005453-4057qib7 2322 6 P120 P120 NNP cord-005453-4057qib7 2322 7 Comparison comparison NN cord-005453-4057qib7 2322 8 between between IN cord-005453-4057qib7 2322 9 two two CD cord-005453-4057qib7 2322 10 reduced reduce VBN cord-005453-4057qib7 2322 11 intensity intensity NN cord-005453-4057qib7 2322 12 conditioning condition VBG cord-005453-4057qib7 2322 13 regimens regimen NNS cord-005453-4057qib7 2322 14 in in IN cord-005453-4057qib7 2322 15 patients patient NNS cord-005453-4057qib7 2322 16 with with IN cord-005453-4057qib7 2322 17 a a DT cord-005453-4057qib7 2322 18 myeloid myeloid JJ cord-005453-4057qib7 2322 19 malignancy malignancy NN cord-005453-4057qib7 2322 20 : : : cord-005453-4057qib7 2322 21 A a DT cord-005453-4057qib7 2322 22 single single JJ cord-005453-4057qib7 2322 23 center center NN cord-005453-4057qib7 2322 24 experience experience NN cord-005453-4057qib7 2322 25 comparing compare VBG cord-005453-4057qib7 2322 26 FB2 FB2 NNP cord-005453-4057qib7 2322 27 with with IN cord-005453-4057qib7 2322 28 flumel flumel JJ cord-005453-4057qib7 2322 29 Background Background NNP cord-005453-4057qib7 2322 30 : : : cord-005453-4057qib7 2322 31 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 2322 32 Stem Stem NNP cord-005453-4057qib7 2322 33 cell cell NN cord-005453-4057qib7 2322 34 transplantation transplantation NN cord-005453-4057qib7 2322 35 ( ( -LRB- cord-005453-4057qib7 2322 36 HSCT HSCT NNP cord-005453-4057qib7 2322 37 ) ) -RRB- cord-005453-4057qib7 2322 38 remains remain VBZ cord-005453-4057qib7 2322 39 the the DT cord-005453-4057qib7 2322 40 only only JJ cord-005453-4057qib7 2322 41 curative curative JJ cord-005453-4057qib7 2322 42 option option NN cord-005453-4057qib7 2322 43 for for IN cord-005453-4057qib7 2322 44 high high JJ cord-005453-4057qib7 2322 45 - - HYPH cord-005453-4057qib7 2322 46 risk risk NN cord-005453-4057qib7 2322 47 myeloid myeloid JJ cord-005453-4057qib7 2322 48 neoplasms neoplasm NNS cord-005453-4057qib7 2322 49 . . . cord-005453-4057qib7 2323 1 The the DT cord-005453-4057qib7 2323 2 optimal optimal JJ cord-005453-4057qib7 2323 3 reduced reduce VBN cord-005453-4057qib7 2323 4 - - HYPH cord-005453-4057qib7 2323 5 intensity intensity NN cord-005453-4057qib7 2323 6 conditioning conditioning NN cord-005453-4057qib7 2323 7 ( ( -LRB- cord-005453-4057qib7 2323 8 RIC RIC NNP cord-005453-4057qib7 2323 9 ) ) -RRB- cord-005453-4057qib7 2323 10 is be VBZ cord-005453-4057qib7 2323 11 still still RB cord-005453-4057qib7 2323 12 debated debate VBN cord-005453-4057qib7 2323 13 . . . cord-005453-4057qib7 2324 1 Methods method NNS cord-005453-4057qib7 2324 2 : : : cord-005453-4057qib7 2325 1 A a DT cord-005453-4057qib7 2325 2 single single JJ cord-005453-4057qib7 2325 3 - - HYPH cord-005453-4057qib7 2325 4 center center NN cord-005453-4057qib7 2325 5 retrospective retrospective JJ cord-005453-4057qib7 2325 6 analysis analysis NN cord-005453-4057qib7 2325 7 was be VBD cord-005453-4057qib7 2325 8 conducted conduct VBN cord-005453-4057qib7 2325 9 at at IN cord-005453-4057qib7 2325 10 our -PRON- PRP$ cord-005453-4057qib7 2325 11 institution institution NN cord-005453-4057qib7 2325 12 to to TO cord-005453-4057qib7 2325 13 compare compare VB cord-005453-4057qib7 2325 14 two two CD cord-005453-4057qib7 2325 15 different different JJ cord-005453-4057qib7 2325 16 RIC RIC NNP cord-005453-4057qib7 2325 17 regimens regimen NNS cord-005453-4057qib7 2325 18 in in IN cord-005453-4057qib7 2325 19 adult adult NN cord-005453-4057qib7 2325 20 patients patient NNS cord-005453-4057qib7 2325 21 transplanted transplant VBN cord-005453-4057qib7 2325 22 for for IN cord-005453-4057qib7 2325 23 myeloid myeloid JJ cord-005453-4057qib7 2325 24 malignancy malignancy NN cord-005453-4057qib7 2325 25 from from IN cord-005453-4057qib7 2325 26 2001 2001 CD cord-005453-4057qib7 2325 27 to to IN cord-005453-4057qib7 2325 28 2018 2018 CD cord-005453-4057qib7 2325 29 . . . cord-005453-4057qib7 2326 1 A a DT cord-005453-4057qib7 2326 2 total total NN cord-005453-4057qib7 2326 3 of of IN cord-005453-4057qib7 2326 4 137 137 CD cord-005453-4057qib7 2326 5 patients patient NNS cord-005453-4057qib7 2326 6 were be VBD cord-005453-4057qib7 2326 7 analysed analyse VBN cord-005453-4057qib7 2326 8 , , , cord-005453-4057qib7 2326 9 74 74 CD cord-005453-4057qib7 2326 10 of of IN cord-005453-4057qib7 2326 11 them -PRON- PRP cord-005453-4057qib7 2326 12 treated treat VBN cord-005453-4057qib7 2326 13 with with IN cord-005453-4057qib7 2326 14 Busulfan Busulfan NNP cord-005453-4057qib7 2326 15 - - HYPH cord-005453-4057qib7 2326 16 based base VBN cord-005453-4057qib7 2326 17 ( ( -LRB- cord-005453-4057qib7 2326 18 Fludarabine Fludarabine NNP cord-005453-4057qib7 2326 19 150 150 CD cord-005453-4057qib7 2326 20 mg mg NNP cord-005453-4057qib7 2326 21 / / SYM cord-005453-4057qib7 2326 22 m m NNP cord-005453-4057qib7 2326 23 2 2 CD cord-005453-4057qib7 2326 24 , , , cord-005453-4057qib7 2326 25 Busulfan Busulfan NNP cord-005453-4057qib7 2326 26 6.4 6.4 CD cord-005453-4057qib7 2326 27 mg mg NNP cord-005453-4057qib7 2326 28 / / SYM cord-005453-4057qib7 2326 29 kg kg NNP cord-005453-4057qib7 2326 30 , , , cord-005453-4057qib7 2326 31 FB2 FB2 NNP cord-005453-4057qib7 2326 32 ) ) -RRB- cord-005453-4057qib7 2326 33 and and CC cord-005453-4057qib7 2326 34 63 63 CD cord-005453-4057qib7 2326 35 with with IN cord-005453-4057qib7 2326 36 Melphalan Melphalan NNP cord-005453-4057qib7 2326 37 - - HYPH cord-005453-4057qib7 2326 38 based base VBN cord-005453-4057qib7 2326 39 conditioning conditioning NN cord-005453-4057qib7 2326 40 regimen regimen NN cord-005453-4057qib7 2326 41 ( ( -LRB- cord-005453-4057qib7 2326 42 Fludarabine Fludarabine NNP cord-005453-4057qib7 2326 43 150 150 CD cord-005453-4057qib7 2326 44 mg mg NNP cord-005453-4057qib7 2326 45 / / SYM cord-005453-4057qib7 2326 46 m m NNP cord-005453-4057qib7 2326 47 2 2 CD cord-005453-4057qib7 2326 48 , , , cord-005453-4057qib7 2326 49 Melphalan Melphalan NNP cord-005453-4057qib7 2326 50 140 140 CD cord-005453-4057qib7 2327 1 mg mg NNP cord-005453-4057qib7 2327 2 / / SYM cord-005453-4057qib7 2327 3 m m NNP cord-005453-4057qib7 2327 4 2 2 CD cord-005453-4057qib7 2327 5 , , , cord-005453-4057qib7 2327 6 FluMel FluMel NNP cord-005453-4057qib7 2327 7 ) ) -RRB- cord-005453-4057qib7 2327 8 . . . cord-005453-4057qib7 2328 1 Antithymocyte Antithymocyte NNP cord-005453-4057qib7 2328 2 globulin globulin NN cord-005453-4057qib7 2328 3 ( ( -LRB- cord-005453-4057qib7 2328 4 ATG ATG NNP cord-005453-4057qib7 2328 5 ) ) -RRB- cord-005453-4057qib7 2328 6 was be VBD cord-005453-4057qib7 2328 7 administered administer VBN cord-005453-4057qib7 2328 8 in in IN cord-005453-4057qib7 2328 9 all all DT cord-005453-4057qib7 2328 10 patients patient NNS cord-005453-4057qib7 2328 11 while while IN cord-005453-4057qib7 2328 12 no no DT cord-005453-4057qib7 2328 13 one one NN cord-005453-4057qib7 2328 14 received receive VBD cord-005453-4057qib7 2328 15 TBI TBI NNP cord-005453-4057qib7 2328 16 . . . cord-005453-4057qib7 2329 1 Partial partial JJ cord-005453-4057qib7 2329 2 in in IN cord-005453-4057qib7 2329 3 vitro vitro FW cord-005453-4057qib7 2329 4 T t NN cord-005453-4057qib7 2329 5 - - HYPH cord-005453-4057qib7 2329 6 cell cell NN cord-005453-4057qib7 2329 7 depletion depletion NN cord-005453-4057qib7 2329 8 was be VBD cord-005453-4057qib7 2329 9 performed perform VBN cord-005453-4057qib7 2329 10 using use VBG cord-005453-4057qib7 2329 11 alemtuzumab alemtuzumab NNS cord-005453-4057qib7 2329 12 for for IN cord-005453-4057qib7 2329 13 low low JJ cord-005453-4057qib7 2329 14 risk risk NN cord-005453-4057qib7 2329 15 patients patient NNS cord-005453-4057qib7 2329 16 . . . cord-005453-4057qib7 2330 1 Results result NNS cord-005453-4057qib7 2330 2 : : : cord-005453-4057qib7 2331 1 The the DT cord-005453-4057qib7 2331 2 two two CD cord-005453-4057qib7 2331 3 groups group NNS cord-005453-4057qib7 2331 4 were be VBD cord-005453-4057qib7 2331 5 well well RB cord-005453-4057qib7 2331 6 balanced balanced JJ cord-005453-4057qib7 2331 7 with with IN cord-005453-4057qib7 2331 8 a a DT cord-005453-4057qib7 2331 9 median median JJ cord-005453-4057qib7 2331 10 age age NN cord-005453-4057qib7 2331 11 of of IN cord-005453-4057qib7 2331 12 61 61 CD cord-005453-4057qib7 2331 13 and and CC cord-005453-4057qib7 2331 14 62 62 CD cord-005453-4057qib7 2331 15 years year NNS cord-005453-4057qib7 2331 16 in in IN cord-005453-4057qib7 2331 17 the the DT cord-005453-4057qib7 2331 18 FB2 FB2 NNP cord-005453-4057qib7 2331 19 and and CC cord-005453-4057qib7 2331 20 FluMel FluMel NNP cord-005453-4057qib7 2331 21 group group NN cord-005453-4057qib7 2331 22 , , , cord-005453-4057qib7 2331 23 respectively respectively RB cord-005453-4057qib7 2331 24 , , , cord-005453-4057qib7 2331 25 and and CC cord-005453-4057qib7 2331 26 a a DT cord-005453-4057qib7 2331 27 median median NN cord-005453-4057qib7 2331 28 follow follow NN cord-005453-4057qib7 2331 29 up up IN cord-005453-4057qib7 2331 30 of of IN cord-005453-4057qib7 2331 31 46 46 CD cord-005453-4057qib7 2331 32 months month NNS cord-005453-4057qib7 2331 33 . . . cord-005453-4057qib7 2332 1 The the DT cord-005453-4057qib7 2332 2 most most RBS cord-005453-4057qib7 2332 3 frequent frequent JJ cord-005453-4057qib7 2332 4 indication indication NN cord-005453-4057qib7 2332 5 for for IN cord-005453-4057qib7 2332 6 transplant transplant NN cord-005453-4057qib7 2332 7 in in IN cord-005453-4057qib7 2332 8 both both DT cord-005453-4057qib7 2332 9 groups group NNS cord-005453-4057qib7 2332 10 was be VBD cord-005453-4057qib7 2332 11 AML AML NNP cord-005453-4057qib7 2332 12 ( ( -LRB- cord-005453-4057qib7 2332 13 59.5 59.5 CD cord-005453-4057qib7 2332 14 and and CC cord-005453-4057qib7 2332 15 69.8 69.8 CD cord-005453-4057qib7 2332 16 % % NN cord-005453-4057qib7 2332 17 for for IN cord-005453-4057qib7 2332 18 FB2 FB2 NNP cord-005453-4057qib7 2332 19 group group NN cord-005453-4057qib7 2332 20 and and CC cord-005453-4057qib7 2332 21 FluMel FluMel NNP cord-005453-4057qib7 2332 22 group group NN cord-005453-4057qib7 2332 23 , , , cord-005453-4057qib7 2332 24 respectively respectively RB cord-005453-4057qib7 2332 25 ) ) -RRB- cord-005453-4057qib7 2332 26 and and CC cord-005453-4057qib7 2332 27 the the DT cord-005453-4057qib7 2332 28 stem stem NN cord-005453-4057qib7 2332 29 cell cell NN cord-005453-4057qib7 2332 30 source source NN cord-005453-4057qib7 2332 31 was be VBD cord-005453-4057qib7 2332 32 peripheral peripheral JJ cord-005453-4057qib7 2332 33 blood blood NN cord-005453-4057qib7 2332 34 in in IN cord-005453-4057qib7 2332 35 94.6 94.6 CD cord-005453-4057qib7 2332 36 and and CC cord-005453-4057qib7 2332 37 96.8 96.8 CD cord-005453-4057qib7 2332 38 % % NN cord-005453-4057qib7 2332 39 of of IN cord-005453-4057qib7 2332 40 patients patient NNS cord-005453-4057qib7 2332 41 . . . cord-005453-4057qib7 2333 1 More More JJR cord-005453-4057qib7 2333 2 patients patient NNS cord-005453-4057qib7 2333 3 in in IN cord-005453-4057qib7 2333 4 the the DT cord-005453-4057qib7 2333 5 first first JJ cord-005453-4057qib7 2333 6 group group NN cord-005453-4057qib7 2333 7 had have VBD cord-005453-4057qib7 2333 8 near near JJ cord-005453-4057qib7 2333 9 to to IN cord-005453-4057qib7 2333 10 significant significant JJ cord-005453-4057qib7 2333 11 worst bad JJS cord-005453-4057qib7 2333 12 Karnosfky Karnosfky NNP cord-005453-4057qib7 2333 13 status status NN cord-005453-4057qib7 2333 14 ( ( -LRB- cord-005453-4057qib7 2333 15 < < XX cord-005453-4057qib7 2333 16 90 90 CD cord-005453-4057qib7 2333 17 ) ) -RRB- cord-005453-4057qib7 2333 18 at at IN cord-005453-4057qib7 2333 19 transplant transplant NN cord-005453-4057qib7 2333 20 compared compare VBN cord-005453-4057qib7 2333 21 to to IN cord-005453-4057qib7 2333 22 second second JJ cord-005453-4057qib7 2333 23 ( ( -LRB- cord-005453-4057qib7 2333 24 35 35 CD cord-005453-4057qib7 2333 25 . . NN cord-005453-4057qib7 2333 26 1 1 CD cord-005453-4057qib7 2333 27 vs vs IN cord-005453-4057qib7 2333 28 19 19 CD cord-005453-4057qib7 2333 29 % % NN cord-005453-4057qib7 2333 30 , , , cord-005453-4057qib7 2333 31 p=0 p=0 NNP cord-005453-4057qib7 2333 32 .057 .057 CD cord-005453-4057qib7 2333 33 ) ) -RRB- cord-005453-4057qib7 2333 34 and and CC cord-005453-4057qib7 2333 35 more more JJR cord-005453-4057qib7 2333 36 patients patient NNS cord-005453-4057qib7 2333 37 received receive VBD cord-005453-4057qib7 2333 38 a a DT cord-005453-4057qib7 2333 39 T t NN cord-005453-4057qib7 2333 40 - - HYPH cord-005453-4057qib7 2333 41 partial partial JJ cord-005453-4057qib7 2333 42 depleted deplete VBN cord-005453-4057qib7 2333 43 graft graft NN cord-005453-4057qib7 2333 44 ( ( -LRB- cord-005453-4057qib7 2333 45 54.1 54.1 CD cord-005453-4057qib7 2333 46 vs vs IN cord-005453-4057qib7 2333 47 33.3 33.3 CD cord-005453-4057qib7 2333 48 % % NN cord-005453-4057qib7 2333 49 , , , cord-005453-4057qib7 2333 50 p= p= NNP cord-005453-4057qib7 2333 51 .028 .028 CD cord-005453-4057qib7 2333 52 ) ) -RRB- cord-005453-4057qib7 2333 53 . . . cord-005453-4057qib7 2334 1 The the DT cord-005453-4057qib7 2334 2 neutrophil neutrophil NN cord-005453-4057qib7 2334 3 engraftment engraftment NN cord-005453-4057qib7 2334 4 was be VBD cord-005453-4057qib7 2334 5 significantly significantly RB cord-005453-4057qib7 2334 6 shorter short JJR cord-005453-4057qib7 2334 7 after after IN cord-005453-4057qib7 2334 8 FluMel FluMel NNP cord-005453-4057qib7 2334 9 ( ( -LRB- cord-005453-4057qib7 2334 10 15 15 CD cord-005453-4057qib7 2334 11 vs vs IN cord-005453-4057qib7 2334 12 18 18 CD cord-005453-4057qib7 2334 13 days day NNS cord-005453-4057qib7 2334 14 , , , cord-005453-4057qib7 2334 15 p p NN cord-005453-4057qib7 2334 16 < < XX cord-005453-4057qib7 2334 17 .01 .01 NFP cord-005453-4057qib7 2334 18 ) ) -RRB- cord-005453-4057qib7 2334 19 . . . cord-005453-4057qib7 2335 1 The the DT cord-005453-4057qib7 2335 2 3-year 3-year CD cord-005453-4057qib7 2335 3 overall overall JJ cord-005453-4057qib7 2335 4 survival survival NN cord-005453-4057qib7 2335 5 ( ( -LRB- cord-005453-4057qib7 2335 6 OS OS NNP cord-005453-4057qib7 2335 7 ) ) -RRB- cord-005453-4057qib7 2335 8 and and CC cord-005453-4057qib7 2335 9 disease disease NN cord-005453-4057qib7 2335 10 - - HYPH cord-005453-4057qib7 2335 11 free free JJ cord-005453-4057qib7 2335 12 survival survival NN cord-005453-4057qib7 2335 13 ( ( -LRB- cord-005453-4057qib7 2335 14 DFS DFS NNP cord-005453-4057qib7 2335 15 ) ) -RRB- cord-005453-4057qib7 2335 16 were be VBD cord-005453-4057qib7 2335 17 of of IN cord-005453-4057qib7 2335 18 43.0 43.0 CD cord-005453-4057qib7 2335 19 and and CC cord-005453-4057qib7 2335 20 36.5 36.5 CD cord-005453-4057qib7 2335 21 % % NN cord-005453-4057qib7 2335 22 , , , cord-005453-4057qib7 2335 23 respectively respectively RB cord-005453-4057qib7 2335 24 , , , cord-005453-4057qib7 2335 25 after after IN cord-005453-4057qib7 2335 26 FB2 FB2 NNP cord-005453-4057qib7 2335 27 and and CC cord-005453-4057qib7 2335 28 54.9 54.9 CD cord-005453-4057qib7 2335 29 and and CC cord-005453-4057qib7 2335 30 52.0 52.0 CD cord-005453-4057qib7 2335 31 % % NN cord-005453-4057qib7 2335 32 after after IN cord-005453-4057qib7 2335 33 FluMel FluMel NNP cord-005453-4057qib7 2335 34 , , , cord-005453-4057qib7 2335 35 respectively respectively RB cord-005453-4057qib7 2335 36 , , , cord-005453-4057qib7 2335 37 and and CC cord-005453-4057qib7 2335 38 were be VBD cord-005453-4057qib7 2335 39 not not RB cord-005453-4057qib7 2335 40 significantly significantly RB cord-005453-4057qib7 2335 41 different different JJ cord-005453-4057qib7 2335 42 ( ( -LRB- cord-005453-4057qib7 2335 43 p=.41 p=.41 NN cord-005453-4057qib7 2335 44 for for IN cord-005453-4057qib7 2335 45 OS OS NNP cord-005453-4057qib7 2335 46 and and CC cord-005453-4057qib7 2335 47 .15 .15 CD cord-005453-4057qib7 2335 48 for for IN cord-005453-4057qib7 2335 49 DFS DFS NNP cord-005453-4057qib7 2335 50 ) ) -RRB- cord-005453-4057qib7 2335 51 , , , cord-005453-4057qib7 2335 52 with with IN cord-005453-4057qib7 2335 53 a a DT cord-005453-4057qib7 2335 54 Karnofsky Karnofsky NNP cord-005453-4057qib7 2336 1 > > XX cord-005453-4057qib7 2337 1 = = SYM cord-005453-4057qib7 2337 2 90 90 CD cord-005453-4057qib7 2338 1 being be VBG cord-005453-4057qib7 2338 2 the the DT cord-005453-4057qib7 2338 3 only only JJ cord-005453-4057qib7 2338 4 factor factor NN cord-005453-4057qib7 2338 5 significantly significantly RB cord-005453-4057qib7 2338 6 associated associate VBN cord-005453-4057qib7 2338 7 in in IN cord-005453-4057qib7 2338 8 univariate univariate JJ cord-005453-4057qib7 2338 9 analysis analysis NN cord-005453-4057qib7 2338 10 with with IN cord-005453-4057qib7 2338 11 better well JJR cord-005453-4057qib7 2338 12 OS OS NNP cord-005453-4057qib7 2338 13 and and CC cord-005453-4057qib7 2338 14 DFS DFS NNP cord-005453-4057qib7 2338 15 ( ( -LRB- cord-005453-4057qib7 2338 16 p=.02 p=.02 CD cord-005453-4057qib7 2338 17 for for IN cord-005453-4057qib7 2338 18 both both DT cord-005453-4057qib7 2338 19 ) ) -RRB- cord-005453-4057qib7 2338 20 . . . cord-005453-4057qib7 2339 1 The the DT cord-005453-4057qib7 2339 2 cumulative cumulative JJ cord-005453-4057qib7 2339 3 incidence incidence NN cord-005453-4057qib7 2339 4 ( ( -LRB- cord-005453-4057qib7 2339 5 CI CI NNP cord-005453-4057qib7 2339 6 ) ) -RRB- cord-005453-4057qib7 2339 7 of of IN cord-005453-4057qib7 2339 8 grade grade NN cord-005453-4057qib7 2339 9 2 2 CD cord-005453-4057qib7 2339 10 to to TO cord-005453-4057qib7 2339 11 4 4 CD cord-005453-4057qib7 2339 12 acute acute JJ cord-005453-4057qib7 2339 13 graft graft NN cord-005453-4057qib7 2339 14 - - HYPH cord-005453-4057qib7 2339 15 versus versus IN cord-005453-4057qib7 2339 16 - - HYPH cord-005453-4057qib7 2339 17 host host NN cord-005453-4057qib7 2339 18 disease disease NN cord-005453-4057qib7 2339 19 ( ( -LRB- cord-005453-4057qib7 2339 20 aGVHD aGVHD NNP cord-005453-4057qib7 2339 21 ) ) -RRB- cord-005453-4057qib7 2339 22 was be VBD cord-005453-4057qib7 2339 23 16.2 16.2 CD cord-005453-4057qib7 2339 24 % % NN cord-005453-4057qib7 2339 25 after after IN cord-005453-4057qib7 2339 26 FB2 FB2 NNP cord-005453-4057qib7 2339 27 and and CC cord-005453-4057qib7 2339 28 38.3 38.3 CD cord-005453-4057qib7 2339 29 % % NN cord-005453-4057qib7 2339 30 after after IN cord-005453-4057qib7 2339 31 FluMel FluMel NNP cord-005453-4057qib7 2340 1 ( ( -LRB- cord-005453-4057qib7 2340 2 p p NN cord-005453-4057qib7 2340 3 < < XX cord-005453-4057qib7 2340 4 .001 .001 CD cord-005453-4057qib7 2340 5 ) ) -RRB- cord-005453-4057qib7 2341 1 and and CC cord-005453-4057qib7 2341 2 was be VBD cord-005453-4057qib7 2341 3 associated associate VBN cord-005453-4057qib7 2341 4 in in IN cord-005453-4057qib7 2341 5 multivariate multivariate JJ cord-005453-4057qib7 2341 6 analysis analysis NN cord-005453-4057qib7 2341 7 with with IN cord-005453-4057qib7 2341 8 both both CC cord-005453-4057qib7 2341 9 T T NNP cord-005453-4057qib7 2341 10 depletion depletion NN cord-005453-4057qib7 2341 11 and and CC cord-005453-4057qib7 2341 12 RIC RIC NNP cord-005453-4057qib7 2341 13 type type NN cord-005453-4057qib7 2341 14 ( ( -LRB- cord-005453-4057qib7 2341 15 p p XX cord-005453-4057qib7 2341 16 < < XX cord-005453-4057qib7 2341 17 .001 .001 CD cord-005453-4057qib7 2341 18 and and CC cord-005453-4057qib7 2341 19 .005 .005 CD cord-005453-4057qib7 2341 20 , , , cord-005453-4057qib7 2341 21 respectively respectively RB cord-005453-4057qib7 2341 22 ) ) -RRB- cord-005453-4057qib7 2341 23 . . . cord-005453-4057qib7 2342 1 The the DT cord-005453-4057qib7 2342 2 CI CI NNP cord-005453-4057qib7 2342 3 of of IN cord-005453-4057qib7 2342 4 chronic chronic JJ cord-005453-4057qib7 2342 5 GVHD GVHD NNP cord-005453-4057qib7 2342 6 at at IN cord-005453-4057qib7 2342 7 3 3 CD cord-005453-4057qib7 2342 8 years year NNS cord-005453-4057qib7 2342 9 was be VBD cord-005453-4057qib7 2342 10 13.9 13.9 CD cord-005453-4057qib7 2342 11 % % NN cord-005453-4057qib7 2342 12 in in IN cord-005453-4057qib7 2342 13 FB2 FB2 NNP cord-005453-4057qib7 2342 14 and and CC cord-005453-4057qib7 2342 15 22.1 22.1 CD cord-005453-4057qib7 2342 16 % % NN cord-005453-4057qib7 2342 17 in in IN cord-005453-4057qib7 2342 18 FluMel FluMel NNP cord-005453-4057qib7 2342 19 group group NN cord-005453-4057qib7 2342 20 ( ( -LRB- cord-005453-4057qib7 2342 21 p=.24 p=.24 NNP cord-005453-4057qib7 2342 22 ) ) -RRB- cord-005453-4057qib7 2342 23 . . . cord-005453-4057qib7 2343 1 The the DT cord-005453-4057qib7 2343 2 CI CI NNP cord-005453-4057qib7 2343 3 of of IN cord-005453-4057qib7 2343 4 Non non JJ cord-005453-4057qib7 2343 5 - - JJ cord-005453-4057qib7 2343 6 relapse relapse JJ cord-005453-4057qib7 2343 7 mortality mortality NN cord-005453-4057qib7 2343 8 at at IN cord-005453-4057qib7 2343 9 3 3 CD cord-005453-4057qib7 2343 10 years year NNS cord-005453-4057qib7 2343 11 was be VBD cord-005453-4057qib7 2343 12 18.7 18.7 CD cord-005453-4057qib7 2343 13 % % NN cord-005453-4057qib7 2343 14 after after IN cord-005453-4057qib7 2343 15 FB2 FB2 NNP cord-005453-4057qib7 2343 16 and and CC cord-005453-4057qib7 2343 17 29.6 29.6 CD cord-005453-4057qib7 2343 18 % % NN cord-005453-4057qib7 2343 19 after after IN cord-005453-4057qib7 2343 20 FluMel FluMel NNP cord-005453-4057qib7 2343 21 ( ( -LRB- cord-005453-4057qib7 2343 22 p=.11 p=.11 NNP cord-005453-4057qib7 2343 23 ) ) -RRB- cord-005453-4057qib7 2343 24 . . . cord-005453-4057qib7 2344 1 The the DT cord-005453-4057qib7 2344 2 CI CI NNP cord-005453-4057qib7 2344 3 of of IN cord-005453-4057qib7 2344 4 relapse relapse NN cord-005453-4057qib7 2344 5 at at IN cord-005453-4057qib7 2344 6 3 3 CD cord-005453-4057qib7 2344 7 years year NNS cord-005453-4057qib7 2344 8 was be VBD cord-005453-4057qib7 2344 9 44.8 44.8 CD cord-005453-4057qib7 2344 10 % % NN cord-005453-4057qib7 2344 11 for for IN cord-005453-4057qib7 2344 12 the the DT cord-005453-4057qib7 2344 13 first first JJ cord-005453-4057qib7 2344 14 and and CC cord-005453-4057qib7 2344 15 18.4 18.4 CD cord-005453-4057qib7 2344 16 % % NN cord-005453-4057qib7 2344 17 for for IN cord-005453-4057qib7 2344 18 the the DT cord-005453-4057qib7 2344 19 second second JJ cord-005453-4057qib7 2344 20 group group NN cord-005453-4057qib7 2344 21 ( ( -LRB- cord-005453-4057qib7 2344 22 p p NN cord-005453-4057qib7 2344 23 < < XX cord-005453-4057qib7 2344 24 .001 .001 CD cord-005453-4057qib7 2344 25 ) ) -RRB- cord-005453-4057qib7 2344 26 and and CC cord-005453-4057qib7 2344 27 was be VBD cord-005453-4057qib7 2344 28 associated associate VBN cord-005453-4057qib7 2344 29 with with IN cord-005453-4057qib7 2344 30 conditioning conditioning NN cord-005453-4057qib7 2344 31 regimen regimen NN cord-005453-4057qib7 2344 32 in in IN cord-005453-4057qib7 2344 33 multivariate multivariate JJ cord-005453-4057qib7 2344 34 analysis analysis NN cord-005453-4057qib7 2344 35 ( ( -LRB- cord-005453-4057qib7 2344 36 p=.02 p=.02 CD cord-005453-4057qib7 2344 37 ) ) -RRB- cord-005453-4057qib7 2344 38 . . . cord-005453-4057qib7 2345 1 No no DT cord-005453-4057qib7 2345 2 difference difference NN cord-005453-4057qib7 2345 3 in in IN cord-005453-4057qib7 2345 4 3-years 3-years JJ cord-005453-4057qib7 2345 5 GVHD GVHD NNP cord-005453-4057qib7 2345 6 - - HYPH cord-005453-4057qib7 2345 7 free/ free/ CD cord-005453-4057qib7 2345 8 relapse relapse NN cord-005453-4057qib7 2345 9 - - HYPH cord-005453-4057qib7 2345 10 free free JJ cord-005453-4057qib7 2345 11 survival survival NN cord-005453-4057qib7 2345 12 ( ( -LRB- cord-005453-4057qib7 2345 13 GRFS GRFS NNP cord-005453-4057qib7 2345 14 ) ) -RRB- cord-005453-4057qib7 2345 15 was be VBD cord-005453-4057qib7 2345 16 observed observe VBN cord-005453-4057qib7 2345 17 between between IN cord-005453-4057qib7 2345 18 the the DT cord-005453-4057qib7 2345 19 two two CD cord-005453-4057qib7 2345 20 group group NN cord-005453-4057qib7 2345 21 ( ( -LRB- cord-005453-4057qib7 2345 22 25.5 25.5 CD cord-005453-4057qib7 2345 23 % % NN cord-005453-4057qib7 2345 24 for for IN cord-005453-4057qib7 2345 25 FB2 FB2 NNP cord-005453-4057qib7 2345 26 and and CC cord-005453-4057qib7 2345 27 37.6 37.6 CD cord-005453-4057qib7 2345 28 % % NN cord-005453-4057qib7 2345 29 for for IN cord-005453-4057qib7 2345 30 FluMel FluMel NNP cord-005453-4057qib7 2345 31 , , , cord-005453-4057qib7 2345 32 p=.48 p=.48 NNP cord-005453-4057qib7 2345 33 ) ) -RRB- cord-005453-4057qib7 2345 34 . . . cord-005453-4057qib7 2346 1 Conclusions conclusion NNS cord-005453-4057qib7 2346 2 : : : cord-005453-4057qib7 2347 1 When when WRB cord-005453-4057qib7 2347 2 comparing compare VBG cord-005453-4057qib7 2347 3 two two CD cord-005453-4057qib7 2347 4 RIC RIC NNP cord-005453-4057qib7 2347 5 regimens regimen NNS cord-005453-4057qib7 2347 6 for for IN cord-005453-4057qib7 2347 7 myeloid myeloid JJ cord-005453-4057qib7 2347 8 neoplasms neoplasm NNS cord-005453-4057qib7 2347 9 , , , cord-005453-4057qib7 2347 10 we -PRON- PRP cord-005453-4057qib7 2347 11 observed observe VBD cord-005453-4057qib7 2347 12 a a DT cord-005453-4057qib7 2347 13 higher high JJR cord-005453-4057qib7 2347 14 incidence incidence NN cord-005453-4057qib7 2347 15 of of IN cord-005453-4057qib7 2347 16 aGVHD aGVHD NNP cord-005453-4057qib7 2347 17 after after IN cord-005453-4057qib7 2347 18 FluMel FluMel NNP cord-005453-4057qib7 2347 19 whereas whereas IN cord-005453-4057qib7 2347 20 no no DT cord-005453-4057qib7 2347 21 statistical statistical JJ cord-005453-4057qib7 2347 22 difference difference NN cord-005453-4057qib7 2347 23 was be VBD cord-005453-4057qib7 2347 24 noted note VBN cord-005453-4057qib7 2347 25 for for IN cord-005453-4057qib7 2347 26 the the DT cord-005453-4057qib7 2347 27 cGVHD cGVHD NNP cord-005453-4057qib7 2347 28 occurrence occurrence NN cord-005453-4057qib7 2347 29 . . . cord-005453-4057qib7 2348 1 While while IN cord-005453-4057qib7 2348 2 the the DT cord-005453-4057qib7 2348 3 toxicity toxicity NN cord-005453-4057qib7 2348 4 appears appear VBZ cord-005453-4057qib7 2348 5 to to TO cord-005453-4057qib7 2348 6 be be VB cord-005453-4057qib7 2348 7 higher high JJR cord-005453-4057qib7 2348 8 after after IN cord-005453-4057qib7 2348 9 FluMel FluMel NNP cord-005453-4057qib7 2348 10 , , , cord-005453-4057qib7 2348 11 this this DT cord-005453-4057qib7 2348 12 result result NN cord-005453-4057qib7 2348 13 is be VBZ cord-005453-4057qib7 2348 14 counterbalanced counterbalance VBN cord-005453-4057qib7 2348 15 by by IN cord-005453-4057qib7 2348 16 a a DT cord-005453-4057qib7 2348 17 higher high JJR cord-005453-4057qib7 2348 18 proportion proportion NN cord-005453-4057qib7 2348 19 of of IN cord-005453-4057qib7 2348 20 relapse relapse NN cord-005453-4057qib7 2348 21 after after IN cord-005453-4057qib7 2348 22 FB2 FB2 NNP cord-005453-4057qib7 2348 23 , , , cord-005453-4057qib7 2348 24 accounting account VBG cord-005453-4057qib7 2348 25 for for IN cord-005453-4057qib7 2348 26 no no DT cord-005453-4057qib7 2348 27 difference difference NN cord-005453-4057qib7 2348 28 in in IN cord-005453-4057qib7 2348 29 OS OS NNP cord-005453-4057qib7 2348 30 , , , cord-005453-4057qib7 2348 31 DFS DFS NNP cord-005453-4057qib7 2348 32 and and CC cord-005453-4057qib7 2348 33 GRFS GRFS NNP cord-005453-4057qib7 2348 34 between between IN cord-005453-4057qib7 2348 35 the the DT cord-005453-4057qib7 2348 36 two two CD cord-005453-4057qib7 2348 37 groups group NNS cord-005453-4057qib7 2348 38 . . . cord-005453-4057qib7 2349 1 These these DT cord-005453-4057qib7 2349 2 findings finding NNS cord-005453-4057qib7 2349 3 could could MD cord-005453-4057qib7 2349 4 be be VB cord-005453-4057qib7 2349 5 partially partially RB cord-005453-4057qib7 2349 6 explained explain VBN cord-005453-4057qib7 2349 7 by by IN cord-005453-4057qib7 2349 8 a a DT cord-005453-4057qib7 2349 9 larger large JJR cord-005453-4057qib7 2349 10 proportion proportion NN cord-005453-4057qib7 2349 11 of of IN cord-005453-4057qib7 2349 12 patients patient NNS cord-005453-4057qib7 2349 13 receiving receive VBG cord-005453-4057qib7 2349 14 a a DT cord-005453-4057qib7 2349 15 partial partial JJ cord-005453-4057qib7 2349 16 T t NN cord-005453-4057qib7 2349 17 - - HYPH cord-005453-4057qib7 2349 18 depletion depletion NN cord-005453-4057qib7 2349 19 after after IN cord-005453-4057qib7 2349 20 FB2 FB2 NNP cord-005453-4057qib7 2349 21 RIC RIC NNP cord-005453-4057qib7 2349 22 , , , cord-005453-4057qib7 2349 23 but but CC cord-005453-4057qib7 2349 24 a a DT cord-005453-4057qib7 2349 25 larger large JJR cord-005453-4057qib7 2349 26 trial trial NN cord-005453-4057qib7 2349 27 is be VBZ cord-005453-4057qib7 2349 28 needed need VBN cord-005453-4057qib7 2349 29 to to TO cord-005453-4057qib7 2349 30 clarify clarify VB cord-005453-4057qib7 2349 31 this this DT cord-005453-4057qib7 2349 32 issue issue NN cord-005453-4057qib7 2349 33 . . . cord-005453-4057qib7 2350 1 Disclosure disclosure NN cord-005453-4057qib7 2350 2 : : : cord-005453-4057qib7 2350 3 Nothing nothing NN cord-005453-4057qib7 2350 4 to to TO cord-005453-4057qib7 2350 5 declare declare VB cord-005453-4057qib7 2350 6 . . . cord-005453-4057qib7 2351 1 Once once RB cord-005453-4057qib7 2351 2 - - HYPH cord-005453-4057qib7 2351 3 daily daily NN cord-005453-4057qib7 2351 4 vs vs IN cord-005453-4057qib7 2351 5 4-times 4-times CD cord-005453-4057qib7 2351 6 daily daily JJ cord-005453-4057qib7 2351 7 intravenous intravenous JJ cord-005453-4057qib7 2351 8 busilvex busilvex NNS cord-005453-4057qib7 2351 9 in in IN cord-005453-4057qib7 2351 10 conditioning conditioning NN cord-005453-4057qib7 2351 11 regimen regimen NN cord-005453-4057qib7 2351 12 before before IN cord-005453-4057qib7 2351 13 allogeneic allogeneic NN cord-005453-4057qib7 2351 14 stem stem NN cord-005453-4057qib7 2351 15 cell cell NN cord-005453-4057qib7 2351 16 transplantation transplantation NN cord-005453-4057qib7 2351 17 for for IN cord-005453-4057qib7 2351 18 patients patient NNS cord-005453-4057qib7 2351 19 with with IN cord-005453-4057qib7 2351 20 myeloid myeloid JJ cord-005453-4057qib7 2351 21 malignancies malignancy NNS cord-005453-4057qib7 2351 22 : : : cord-005453-4057qib7 2352 1 Safety safety NN cord-005453-4057qib7 2352 2 and and CC cord-005453-4057qib7 2352 3 efficacy efficacy NN cord-005453-4057qib7 2352 4 Background background NN cord-005453-4057qib7 2352 5 : : : cord-005453-4057qib7 2353 1 Busilvex Busilvex NNP cord-005453-4057qib7 2353 2 ( ( -LRB- cord-005453-4057qib7 2353 3 Bu Bu NNP cord-005453-4057qib7 2353 4 ) ) -RRB- cord-005453-4057qib7 2353 5 is be VBZ cord-005453-4057qib7 2353 6 part part NN cord-005453-4057qib7 2353 7 of of IN cord-005453-4057qib7 2353 8 standard standard JJ cord-005453-4057qib7 2353 9 conditioning conditioning NN cord-005453-4057qib7 2353 10 regimen regimen NN cord-005453-4057qib7 2353 11 before before IN cord-005453-4057qib7 2353 12 allogeneic allogeneic NN cord-005453-4057qib7 2353 13 stem stem NN cord-005453-4057qib7 2353 14 cell cell NN cord-005453-4057qib7 2353 15 transplantation transplantation NN cord-005453-4057qib7 2353 16 ( ( -LRB- cord-005453-4057qib7 2353 17 ASCT ASCT NNP cord-005453-4057qib7 2353 18 ) ) -RRB- cord-005453-4057qib7 2353 19 for for IN cord-005453-4057qib7 2353 20 patients patient NNS cord-005453-4057qib7 2353 21 with with IN cord-005453-4057qib7 2353 22 myeloid myeloid JJ cord-005453-4057qib7 2353 23 malignancies malignancy NNS cord-005453-4057qib7 2353 24 and and CC cord-005453-4057qib7 2353 25 usually usually RB cord-005453-4057qib7 2353 26 administered administer VBN cord-005453-4057qib7 2353 27 as as IN cord-005453-4057qib7 2353 28 an an DT cord-005453-4057qib7 2353 29 intravenous intravenous JJ cord-005453-4057qib7 2353 30 ( ( -LRB- cord-005453-4057qib7 2353 31 iv iv LS cord-005453-4057qib7 2353 32 ) ) -RRB- cord-005453-4057qib7 2353 33 infusion infusion NN cord-005453-4057qib7 2353 34 4-times 4-times CD cord-005453-4057qib7 2353 35 daily daily RB cord-005453-4057qib7 2353 36 . . . cord-005453-4057qib7 2354 1 This this DT cord-005453-4057qib7 2354 2 study study NN cord-005453-4057qib7 2354 3 aimed aim VBD cord-005453-4057qib7 2354 4 to to TO cord-005453-4057qib7 2354 5 compare compare VB cord-005453-4057qib7 2354 6 the the DT cord-005453-4057qib7 2354 7 saftey saftey NN cord-005453-4057qib7 2354 8 and and CC cord-005453-4057qib7 2354 9 efficacy efficacy NN cord-005453-4057qib7 2354 10 of of IN cord-005453-4057qib7 2354 11 this this DT cord-005453-4057qib7 2354 12 schedule schedule NN cord-005453-4057qib7 2354 13 to to IN cord-005453-4057qib7 2354 14 a a DT cord-005453-4057qib7 2354 15 once once RB cord-005453-4057qib7 2354 16 - - HYPH cord-005453-4057qib7 2354 17 daily daily NN cord-005453-4057qib7 2354 18 iv iv NNP cord-005453-4057qib7 2354 19 Bu Bu NNP cord-005453-4057qib7 2354 20 . . . cord-005453-4057qib7 2355 1 We -PRON- PRP cord-005453-4057qib7 2355 2 conducted conduct VBD cord-005453-4057qib7 2355 3 a a DT cord-005453-4057qib7 2355 4 retrospective retrospective JJ cord-005453-4057qib7 2355 5 study study NN cord-005453-4057qib7 2355 6 in in IN cord-005453-4057qib7 2355 7 adult adult NN cord-005453-4057qib7 2355 8 patients patient NNS cord-005453-4057qib7 2355 9 ( ( -LRB- cord-005453-4057qib7 2355 10 ≥18 ≥18 IN cord-005453-4057qib7 2355 11 years year NNS cord-005453-4057qib7 2355 12 ) ) -RRB- cord-005453-4057qib7 2355 13 with with IN cord-005453-4057qib7 2355 14 myeloid myeloid JJ cord-005453-4057qib7 2355 15 malignancies malignancy NNS cord-005453-4057qib7 2355 16 who who WP cord-005453-4057qib7 2355 17 received receive VBD cord-005453-4057qib7 2355 18 ASCT ASCT NNP cord-005453-4057qib7 2355 19 from from IN cord-005453-4057qib7 2355 20 HLA HLA NNP cord-005453-4057qib7 2355 21 - - HYPH cord-005453-4057qib7 2355 22 identical identical JJ cord-005453-4057qib7 2355 23 sibling sibling NN cord-005453-4057qib7 2355 24 donors donor NNS cord-005453-4057qib7 2355 25 between between IN cord-005453-4057qib7 2355 26 January January NNP cord-005453-4057qib7 2355 27 2011 2011 CD cord-005453-4057qib7 2355 28 and and CC cord-005453-4057qib7 2355 29 June June NNP cord-005453-4057qib7 2355 30 2018 2018 CD cord-005453-4057qib7 2355 31 following follow VBG cord-005453-4057qib7 2355 32 iv iv NNP cord-005453-4057qib7 2355 33 Bu Bu NNP cord-005453-4057qib7 2355 34 - - HYPH cord-005453-4057qib7 2355 35 based base VBN cord-005453-4057qib7 2355 36 preparative preparative JJ cord-005453-4057qib7 2355 37 regimens regimen NNS cord-005453-4057qib7 2355 38 . . . cord-005453-4057qib7 2356 1 Graft graft NN cord-005453-4057qib7 2356 2 - - HYPH cord-005453-4057qib7 2356 3 versus versus NN cord-005453-4057qib7 2356 4 host host NN cord-005453-4057qib7 2356 5 disease disease NN cord-005453-4057qib7 2356 6 ( ( -LRB- cord-005453-4057qib7 2356 7 GVHD GVHD NNP cord-005453-4057qib7 2356 8 ) ) -RRB- cord-005453-4057qib7 2356 9 prophylaxis prophylaxis NN cord-005453-4057qib7 2356 10 consited consite VBN cord-005453-4057qib7 2356 11 of of IN cord-005453-4057qib7 2356 12 cyclosporine cyclosporine JJ cord-005453-4057qib7 2356 13 and and CC cord-005453-4057qib7 2356 14 short short JJ cord-005453-4057qib7 2356 15 course course NN cord-005453-4057qib7 2356 16 of of IN cord-005453-4057qib7 2356 17 methotrexate methotrexate NNP cord-005453-4057qib7 2356 18 . . . cord-005453-4057qib7 2357 1 Intravenous Intravenous NNP cord-005453-4057qib7 2357 2 Bu Bu NNP cord-005453-4057qib7 2357 3 was be VBD cord-005453-4057qib7 2357 4 administered administer VBN cord-005453-4057qib7 2357 5 4-times 4-times CD cord-005453-4057qib7 2357 6 daily daily NN cord-005453-4057qib7 2357 7 ( ( -LRB- cord-005453-4057qib7 2357 8 0.8 0.8 CD cord-005453-4057qib7 2357 9 mg mg NNP cord-005453-4057qib7 2357 10 / / SYM cord-005453-4057qib7 2357 11 kg kg NNP cord-005453-4057qib7 2358 1 every every DT cord-005453-4057qib7 2358 2 6 6 CD cord-005453-4057qib7 2358 3 hours hour NNS cord-005453-4057qib7 2358 4 x12 x12 CD cord-005453-4057qib7 2358 5 to to IN cord-005453-4057qib7 2358 6 16 16 CD cord-005453-4057qib7 2358 7 doses dose NNS cord-005453-4057qib7 2358 8 ) ) -RRB- cord-005453-4057qib7 2358 9 or or CC cord-005453-4057qib7 2358 10 oncedaily oncedaily RB cord-005453-4057qib7 2358 11 in in IN cord-005453-4057qib7 2358 12 a a DT cord-005453-4057qib7 2358 13 3-hour 3-hour CD cord-005453-4057qib7 2358 14 infusion infusion NN cord-005453-4057qib7 2358 15 ( ( -LRB- cord-005453-4057qib7 2358 16 3.2 3.2 CD cord-005453-4057qib7 2358 17 mg mg NNP cord-005453-4057qib7 2358 18 / / SYM cord-005453-4057qib7 2358 19 kg kg NNP cord-005453-4057qib7 2358 20 x x SYM cord-005453-4057qib7 2358 21 3 3 CD cord-005453-4057qib7 2358 22 to to TO cord-005453-4057qib7 2358 23 4 4 CD cord-005453-4057qib7 2358 24 days day NNS cord-005453-4057qib7 2358 25 ) ) -RRB- cord-005453-4057qib7 2358 26 since since IN cord-005453-4057qib7 2358 27 June June NNP cord-005453-4057qib7 2358 28 2015 2015 CD cord-005453-4057qib7 2358 29 . . . cord-005453-4057qib7 2359 1 Results result NNS cord-005453-4057qib7 2359 2 : : : cord-005453-4057qib7 2360 1 Ninty ninty CD cord-005453-4057qib7 2360 2 - - HYPH cord-005453-4057qib7 2360 3 nine nine CD cord-005453-4057qib7 2360 4 patients patient NNS cord-005453-4057qib7 2360 5 were be VBD cord-005453-4057qib7 2360 6 enrolled enrol VBN cord-005453-4057qib7 2360 7 ( ( -LRB- cord-005453-4057qib7 2360 8 54 54 CD cord-005453-4057qib7 2360 9 men man NNS cord-005453-4057qib7 2360 10 and and CC cord-005453-4057qib7 2360 11 45 45 CD cord-005453-4057qib7 2360 12 women woman NNS cord-005453-4057qib7 2360 13 ) ) -RRB- cord-005453-4057qib7 2360 14 . . . cord-005453-4057qib7 2361 1 Median median JJ cord-005453-4057qib7 2361 2 age age NN cord-005453-4057qib7 2361 3 was be VBD cord-005453-4057qib7 2361 4 35 35 CD cord-005453-4057qib7 2361 5 years year NNS cord-005453-4057qib7 2362 1 ( ( -LRB- cord-005453-4057qib7 2362 2 range range NN cord-005453-4057qib7 2362 3 , , , cord-005453-4057qib7 2362 4 18 18 CD cord-005453-4057qib7 2362 5 - - SYM cord-005453-4057qib7 2362 6 50 50 CD cord-005453-4057qib7 2362 7 y y NN cord-005453-4057qib7 2362 8 ) ) -RRB- cord-005453-4057qib7 2362 9 . . . cord-005453-4057qib7 2363 1 The the DT cord-005453-4057qib7 2363 2 median median JJ cord-005453-4057qib7 2363 3 time time NN cord-005453-4057qib7 2363 4 from from IN cord-005453-4057qib7 2363 5 diagnosis diagnosis NN cord-005453-4057qib7 2363 6 to to IN cord-005453-4057qib7 2363 7 ASCT ASCT NNP cord-005453-4057qib7 2363 8 was be VBD cord-005453-4057qib7 2363 9 5 5 CD cord-005453-4057qib7 2363 10 months month NNS cord-005453-4057qib7 2363 11 ( ( -LRB- cord-005453-4057qib7 2363 12 range range NN cord-005453-4057qib7 2363 13 , , , cord-005453-4057qib7 2363 14 51days 51days CD cord-005453-4057qib7 2363 15 -7 -7 CD cord-005453-4057qib7 2363 16 years year NNS cord-005453-4057qib7 2363 17 ) ) -RRB- cord-005453-4057qib7 2363 18 . . . cord-005453-4057qib7 2364 1 Diagnosis diagnosis NN cord-005453-4057qib7 2364 2 were be VBD cord-005453-4057qib7 2364 3 acute acute JJ cord-005453-4057qib7 2364 4 myeloid myeloid JJ cord-005453-4057qib7 2364 5 leukemia leukemia NN cord-005453-4057qib7 2364 6 ( ( -LRB- cord-005453-4057qib7 2364 7 n=79 n=79 NN cord-005453-4057qib7 2364 8 , , , cord-005453-4057qib7 2364 9 80 80 CD cord-005453-4057qib7 2364 10 % % NN cord-005453-4057qib7 2364 11 ) ) -RRB- cord-005453-4057qib7 2364 12 , , , cord-005453-4057qib7 2364 13 chronic chronic JJ cord-005453-4057qib7 2364 14 myeloid myeloid NN cord-005453-4057qib7 2364 15 leukemia leukemia NN cord-005453-4057qib7 2364 16 ( ( -LRB- cord-005453-4057qib7 2364 17 n=8 n=8 NN cord-005453-4057qib7 2364 18 , , , cord-005453-4057qib7 2364 19 8 8 CD cord-005453-4057qib7 2364 20 % % NN cord-005453-4057qib7 2364 21 ) ) -RRB- cord-005453-4057qib7 2364 22 , , , cord-005453-4057qib7 2364 23 myelodysplasic myelodysplasic NNP cord-005453-4057qib7 2364 24 syndrome syndrome NNP cord-005453-4057qib7 2364 25 ( ( -LRB- cord-005453-4057qib7 2364 26 n=6 n=6 NNP cord-005453-4057qib7 2364 27 , , , cord-005453-4057qib7 2364 28 6 6 CD cord-005453-4057qib7 2364 29 % % NN cord-005453-4057qib7 2364 30 ) ) -RRB- cord-005453-4057qib7 2364 31 , , , cord-005453-4057qib7 2364 32 primitive primitive JJ cord-005453-4057qib7 2364 33 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 2364 34 ( ( -LRB- cord-005453-4057qib7 2364 35 n=4 n=4 NNP cord-005453-4057qib7 2364 36 , , , cord-005453-4057qib7 2364 37 4 4 CD cord-005453-4057qib7 2364 38 % % NN cord-005453-4057qib7 2364 39 ) ) -RRB- cord-005453-4057qib7 2364 40 and and CC cord-005453-4057qib7 2364 41 chronic chronic JJ cord-005453-4057qib7 2364 42 myelomonocytic myelomonocytic JJ cord-005453-4057qib7 2364 43 leukemia leukemia NN cord-005453-4057qib7 2364 44 ( ( -LRB- cord-005453-4057qib7 2364 45 n=2 n=2 NNS cord-005453-4057qib7 2364 46 , , , cord-005453-4057qib7 2364 47 2 2 CD cord-005453-4057qib7 2364 48 % % NN cord-005453-4057qib7 2364 49 ) ) -RRB- cord-005453-4057qib7 2364 50 . . . cord-005453-4057qib7 2365 1 Thirty thirty CD cord-005453-4057qib7 2365 2 - - HYPH cord-005453-4057qib7 2365 3 seven seven CD cord-005453-4057qib7 2365 4 ( ( -LRB- cord-005453-4057qib7 2365 5 37.3 37.3 CD cord-005453-4057qib7 2365 6 % % NN cord-005453-4057qib7 2365 7 ) ) -RRB- cord-005453-4057qib7 2365 8 patients patient NNS cord-005453-4057qib7 2365 9 had have VBD cord-005453-4057qib7 2365 10 EBMT EBMT NNP cord-005453-4057qib7 2365 11 - - HYPH cord-005453-4057qib7 2365 12 score score NN cord-005453-4057qib7 2365 13 ≥2 ≥2 NNP cord-005453-4057qib7 2365 14 . . . cord-005453-4057qib7 2366 1 Sixty sixty CD cord-005453-4057qib7 2366 2 - - HYPH cord-005453-4057qib7 2366 3 five five CD cord-005453-4057qib7 2366 4 ( ( -LRB- cord-005453-4057qib7 2366 5 65.6 65.6 CD cord-005453-4057qib7 2366 6 % % NN cord-005453-4057qib7 2366 7 ) ) -RRB- cord-005453-4057qib7 2366 8 patients patient NNS cord-005453-4057qib7 2366 9 were be VBD cord-005453-4057qib7 2366 10 transplanted transplant VBN cord-005453-4057qib7 2366 11 in in IN cord-005453-4057qib7 2366 12 CR1 CR1 NNP cord-005453-4057qib7 2366 13 , , , cord-005453-4057qib7 2366 14 5 5 CD cord-005453-4057qib7 2366 15 ( ( -LRB- cord-005453-4057qib7 2366 16 5 5 CD cord-005453-4057qib7 2366 17 % % NN cord-005453-4057qib7 2366 18 ) ) -RRB- cord-005453-4057qib7 2366 19 beyond beyond IN cord-005453-4057qib7 2366 20 CR1 CR1 NNP cord-005453-4057qib7 2366 21 and and CC cord-005453-4057qib7 2366 22 24 24 CD cord-005453-4057qib7 2366 23 ( ( -LRB- cord-005453-4057qib7 2366 24 24.2 24.2 CD cord-005453-4057qib7 2366 25 % % NN cord-005453-4057qib7 2366 26 ) ) -RRB- cord-005453-4057qib7 2366 27 had have VBD cord-005453-4057qib7 2366 28 active active JJ cord-005453-4057qib7 2366 29 disease disease NN cord-005453-4057qib7 2366 30 . . . cord-005453-4057qib7 2367 1 Conditioning conditioning NN cord-005453-4057qib7 2367 2 regimens regimen NNS cord-005453-4057qib7 2367 3 consisted consist VBN cord-005453-4057qib7 2367 4 of of IN cord-005453-4057qib7 2367 5 Bu Bu NNP cord-005453-4057qib7 2367 6 / / , cord-005453-4057qib7 2367 7 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 2367 8 in in IN cord-005453-4057qib7 2367 9 86 86 CD cord-005453-4057qib7 2367 10 patients patient NNS cord-005453-4057qib7 2367 11 ( ( -LRB- cord-005453-4057qib7 2367 12 86.8 86.8 CD cord-005453-4057qib7 2367 13 % % NN cord-005453-4057qib7 2367 14 ) ) -RRB- cord-005453-4057qib7 2368 1 , , , cord-005453-4057qib7 2368 2 Bu Bu NNP cord-005453-4057qib7 2368 3 / / SYM cord-005453-4057qib7 2368 4 fludarabine fludarabine NN cord-005453-4057qib7 2368 5 in in IN cord-005453-4057qib7 2368 6 13 13 CD cord-005453-4057qib7 2368 7 patients patient NNS cord-005453-4057qib7 2368 8 ( ( -LRB- cord-005453-4057qib7 2368 9 13.1 13.1 CD cord-005453-4057qib7 2368 10 % % NN cord-005453-4057qib7 2368 11 ) ) -RRB- cord-005453-4057qib7 2368 12 . . . cord-005453-4057qib7 2369 1 Four four CD cord-005453-4057qib7 2369 2 - - HYPH cord-005453-4057qib7 2369 3 times time NNS cord-005453-4057qib7 2369 4 daily daily JJ cord-005453-4057qib7 2369 5 Bu Bu NNP cord-005453-4057qib7 2369 6 was be VBD cord-005453-4057qib7 2369 7 given give VBN cord-005453-4057qib7 2369 8 to to IN cord-005453-4057qib7 2369 9 58 58 CD cord-005453-4057qib7 2369 10 patients patient NNS cord-005453-4057qib7 2369 11 ( ( -LRB- cord-005453-4057qib7 2369 12 58.5 58.5 CD cord-005453-4057qib7 2369 13 % % NN cord-005453-4057qib7 2369 14 , , , cord-005453-4057qib7 2369 15 groupe1 groupe1 NN cord-005453-4057qib7 2369 16 ) ) -RRB- cord-005453-4057qib7 2369 17 and and CC cord-005453-4057qib7 2369 18 once once RB cord-005453-4057qib7 2369 19 - - HYPH cord-005453-4057qib7 2369 20 daily daily NN cord-005453-4057qib7 2369 21 Bu Bu NNP cord-005453-4057qib7 2369 22 to to IN cord-005453-4057qib7 2369 23 41 41 CD cord-005453-4057qib7 2369 24 patients patient NNS cord-005453-4057qib7 2369 25 ( ( -LRB- cord-005453-4057qib7 2369 26 41.5 41.5 CD cord-005453-4057qib7 2369 27 % % NN cord-005453-4057qib7 2369 28 , , , cord-005453-4057qib7 2369 29 groupe groupe NNP cord-005453-4057qib7 2369 30 2 2 CD cord-005453-4057qib7 2369 31 ) ) -RRB- cord-005453-4057qib7 2369 32 . . . cord-005453-4057qib7 2370 1 Stem stem JJ cord-005453-4057qib7 2370 2 cell cell NN cord-005453-4057qib7 2370 3 source source NN cord-005453-4057qib7 2370 4 were be VBD cord-005453-4057qib7 2370 5 BM BM NNP cord-005453-4057qib7 2370 6 in in IN cord-005453-4057qib7 2370 7 46 46 CD cord-005453-4057qib7 2370 8 patients patient NNS cord-005453-4057qib7 2370 9 ( ( -LRB- cord-005453-4057qib7 2370 10 46.5 46.5 CD cord-005453-4057qib7 2370 11 % % NN cord-005453-4057qib7 2370 12 ) ) -RRB- cord-005453-4057qib7 2370 13 and and CC cord-005453-4057qib7 2370 14 PBSC PBSC NNP cord-005453-4057qib7 2370 15 in in IN cord-005453-4057qib7 2370 16 53 53 CD cord-005453-4057qib7 2370 17 patients patient NNS cord-005453-4057qib7 2370 18 ( ( -LRB- cord-005453-4057qib7 2370 19 53.5 53.5 CD cord-005453-4057qib7 2370 20 % % NN cord-005453-4057qib7 2370 21 ) ) -RRB- cord-005453-4057qib7 2370 22 . . . cord-005453-4057qib7 2371 1 Globally globally RB cord-005453-4057qib7 2371 2 , , , cord-005453-4057qib7 2371 3 patients patient NNS cord-005453-4057qib7 2371 4 characteristics characteristic NNS cord-005453-4057qib7 2371 5 were be VBD cord-005453-4057qib7 2371 6 well well RB cord-005453-4057qib7 2371 7 balanced balanced JJ cord-005453-4057qib7 2371 8 between between IN cord-005453-4057qib7 2371 9 the the DT cord-005453-4057qib7 2371 10 two two CD cord-005453-4057qib7 2371 11 groups group NNS cord-005453-4057qib7 2371 12 . . . cord-005453-4057qib7 2372 1 The the DT cord-005453-4057qib7 2372 2 rates rate NNS cord-005453-4057qib7 2372 3 of of IN cord-005453-4057qib7 2372 4 severe severe JJ cord-005453-4057qib7 2372 5 complications complication NNS cord-005453-4057qib7 2372 6 were be VBD cord-005453-4057qib7 2372 7 similar similar JJ cord-005453-4057qib7 2372 8 between between IN cord-005453-4057qib7 2372 9 the the DT cord-005453-4057qib7 2372 10 two two CD cord-005453-4057qib7 2372 11 groups group NNS cord-005453-4057qib7 2372 12 with with IN cord-005453-4057qib7 2372 13 no no DT cord-005453-4057qib7 2372 14 statistically statistically RB cord-005453-4057qib7 2372 15 significant significant JJ cord-005453-4057qib7 2372 16 differences difference NNS cord-005453-4057qib7 2372 17 except except IN cord-005453-4057qib7 2372 18 oral oral JJ cord-005453-4057qib7 2372 19 mucositis mucositis NN cord-005453-4057qib7 2372 20 ( ( -LRB- cord-005453-4057qib7 2372 21 table1 table1 NN cord-005453-4057qib7 2372 22 ) ) -RRB- cord-005453-4057qib7 2372 23 . . . cord-005453-4057qib7 2373 1 Non non JJ cord-005453-4057qib7 2373 2 - - JJ cord-005453-4057qib7 2373 3 relapse relapse JJ cord-005453-4057qib7 2373 4 mortality mortality NN cord-005453-4057qib7 2373 5 ( ( -LRB- cord-005453-4057qib7 2373 6 NRM NRM NNP cord-005453-4057qib7 2373 7 ) ) -RRB- cord-005453-4057qib7 2373 8 was be VBD cord-005453-4057qib7 2373 9 comparable comparable JJ cord-005453-4057qib7 2373 10 in in IN cord-005453-4057qib7 2373 11 the the DT cord-005453-4057qib7 2373 12 two two CD cord-005453-4057qib7 2373 13 groups group NNS cord-005453-4057qib7 2373 14 ( ( -LRB- cord-005453-4057qib7 2373 15 21 21 CD cord-005453-4057qib7 2373 16 % % NN cord-005453-4057qib7 2373 17 and and CC cord-005453-4057qib7 2373 18 17 17 CD cord-005453-4057qib7 2373 19 % % NN cord-005453-4057qib7 2373 20 in in IN cord-005453-4057qib7 2373 21 groups group NNS cord-005453-4057qib7 2373 22 1 1 CD cord-005453-4057qib7 2373 23 and and CC cord-005453-4057qib7 2373 24 2 2 CD cord-005453-4057qib7 2373 25 , , , cord-005453-4057qib7 2373 26 respectively respectively RB cord-005453-4057qib7 2373 27 , , , cord-005453-4057qib7 2373 28 p=0.65 p=0.65 NNP cord-005453-4057qib7 2373 29 ) ) -RRB- cord-005453-4057qib7 2373 30 . . . cord-005453-4057qib7 2374 1 The the DT cord-005453-4057qib7 2374 2 relapse relapse NN cord-005453-4057qib7 2374 3 rate rate NN cord-005453-4057qib7 2374 4 was be VBD cord-005453-4057qib7 2374 5 24 24 CD cord-005453-4057qib7 2374 6 % % NN cord-005453-4057qib7 2374 7 and and CC cord-005453-4057qib7 2374 8 32 32 CD cord-005453-4057qib7 2374 9 % % NN cord-005453-4057qib7 2374 10 , , , cord-005453-4057qib7 2374 11 respectively respectively RB cord-005453-4057qib7 2374 12 ( ( -LRB- cord-005453-4057qib7 2374 13 p=0.4 p=0.4 NNP cord-005453-4057qib7 2374 14 ) ) -RRB- cord-005453-4057qib7 2374 15 . . . cord-005453-4057qib7 2375 1 After after IN cord-005453-4057qib7 2375 2 a a DT cord-005453-4057qib7 2375 3 median median JJ cord-005453-4057qib7 2375 4 follow follow NN cord-005453-4057qib7 2375 5 - - HYPH cord-005453-4057qib7 2375 6 up up NN cord-005453-4057qib7 2375 7 of of IN cord-005453-4057qib7 2375 8 2 2 CD cord-005453-4057qib7 2375 9 years year NNS cord-005453-4057qib7 2375 10 ( ( -LRB- cord-005453-4057qib7 2375 11 range range NN cord-005453-4057qib7 2375 12 , , , cord-005453-4057qib7 2375 13 5days 5days CD cord-005453-4057qib7 2375 14 -7years -7year NNS cord-005453-4057qib7 2375 15 ) ) -RRB- cord-005453-4057qib7 2375 16 , , , cord-005453-4057qib7 2375 17 the the DT cord-005453-4057qib7 2375 18 OS OS NNP cord-005453-4057qib7 2375 19 was be VBD cord-005453-4057qib7 2375 20 not not RB cord-005453-4057qib7 2375 21 significantly significantly RB cord-005453-4057qib7 2375 22 different different JJ cord-005453-4057qib7 2375 23 between between IN cord-005453-4057qib7 2375 24 groups group NNS cord-005453-4057qib7 2375 25 1 1 CD cord-005453-4057qib7 2375 26 and and CC cord-005453-4057qib7 2375 27 2 2 CD cord-005453-4057qib7 2375 28 : : : cord-005453-4057qib7 2375 29 64 64 CD cord-005453-4057qib7 2375 30 % % NN cord-005453-4057qib7 2375 31 vs vs IN cord-005453-4057qib7 2375 32 56 56 CD cord-005453-4057qib7 2375 33 % % NN cord-005453-4057qib7 2375 34 ( ( -LRB- cord-005453-4057qib7 2375 35 p=0.09 p=0.09 NN cord-005453-4057qib7 2375 36 ) ) -RRB- cord-005453-4057qib7 2375 37 . . . cord-005453-4057qib7 2376 1 However however RB cord-005453-4057qib7 2376 2 , , , cord-005453-4057qib7 2376 3 the the DT cord-005453-4057qib7 2376 4 RFS RFS NNP cord-005453-4057qib7 2376 5 was be VBD cord-005453-4057qib7 2376 6 significantly significantly RB cord-005453-4057qib7 2376 7 better well JJR cord-005453-4057qib7 2376 8 in in IN cord-005453-4057qib7 2376 9 the the DT cord-005453-4057qib7 2376 10 groupe groupe NNP cord-005453-4057qib7 2376 11 1 1 CD cord-005453-4057qib7 2376 12 : : : cord-005453-4057qib7 2376 13 62 62 CD cord-005453-4057qib7 2376 14 % % NN cord-005453-4057qib7 2376 15 vs vs IN cord-005453-4057qib7 2376 16 56 56 CD cord-005453-4057qib7 2376 17 % % NN cord-005453-4057qib7 2376 18 ( ( -LRB- cord-005453-4057qib7 2376 19 p=0.03 p=0.03 NN cord-005453-4057qib7 2376 20 ) ) -RRB- cord-005453-4057qib7 2376 21 . . . cord-005453-4057qib7 2377 1 Conclusions conclusion NNS cord-005453-4057qib7 2377 2 : : : cord-005453-4057qib7 2378 1 Once once RB cord-005453-4057qib7 2378 2 - - HYPH cord-005453-4057qib7 2378 3 daily daily NN cord-005453-4057qib7 2378 4 iv iv . cord-005453-4057qib7 2378 5 Bu Bu NNP cord-005453-4057qib7 2378 6 regimen regimen NN cord-005453-4057qib7 2378 7 seems seem VBZ cord-005453-4057qib7 2378 8 to to TO cord-005453-4057qib7 2378 9 be be VB cord-005453-4057qib7 2378 10 an an DT cord-005453-4057qib7 2378 11 efficient efficient JJ cord-005453-4057qib7 2378 12 and and CC cord-005453-4057qib7 2378 13 safe safe JJ cord-005453-4057qib7 2378 14 alternative alternative NN cord-005453-4057qib7 2378 15 to to IN cord-005453-4057qib7 2378 16 the the DT cord-005453-4057qib7 2378 17 4-times 4-times CD cord-005453-4057qib7 2378 18 daily daily JJ cord-005453-4057qib7 2378 19 protocol protocol NN cord-005453-4057qib7 2378 20 . . . cord-005453-4057qib7 2379 1 However however RB cord-005453-4057qib7 2379 2 , , , cord-005453-4057qib7 2379 3 results result NNS cord-005453-4057qib7 2379 4 should should MD cord-005453-4057qib7 2379 5 be be VB cord-005453-4057qib7 2379 6 interpreted interpret VBN cord-005453-4057qib7 2379 7 with with IN cord-005453-4057qib7 2379 8 caution caution NN cord-005453-4057qib7 2379 9 because because IN cord-005453-4057qib7 2379 10 the the DT cord-005453-4057qib7 2379 11 historical historical JJ cord-005453-4057qib7 2379 12 comparison comparison NN cord-005453-4057qib7 2379 13 and and CC cord-005453-4057qib7 2379 14 lack lack NN cord-005453-4057qib7 2379 15 of of IN cord-005453-4057qib7 2379 16 Bu Bu NNP cord-005453-4057qib7 2379 17 pharmacokinetics pharmacokinetics NNP cord-005453-4057qib7 2379 18 studies study NNS cord-005453-4057qib7 2379 19 . . . cord-005453-4057qib7 2380 1 Disclosure disclosure NN cord-005453-4057qib7 2380 2 Background background NN cord-005453-4057qib7 2380 3 : : : cord-005453-4057qib7 2381 1 Standard standard JJ cord-005453-4057qib7 2381 2 therapy therapy NN cord-005453-4057qib7 2381 3 of of IN cord-005453-4057qib7 2381 4 the the DT cord-005453-4057qib7 2381 5 most most JJS cord-005453-4057qib7 2381 6 patients patient NNS cord-005453-4057qib7 2381 7 with with IN cord-005453-4057qib7 2381 8 juvenile juvenile JJ cord-005453-4057qib7 2381 9 myelomonocytic myelomonocytic NN cord-005453-4057qib7 2381 10 leukemia leukemia NN cord-005453-4057qib7 2381 11 ( ( -LRB- cord-005453-4057qib7 2381 12 JMML JMML NNP cord-005453-4057qib7 2381 13 ) ) -RRB- cord-005453-4057qib7 2381 14 is be VBZ cord-005453-4057qib7 2381 15 allogeneic allogeneic VBG cord-005453-4057qib7 2381 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 2381 17 stem stem NN cord-005453-4057qib7 2381 18 cell cell NN cord-005453-4057qib7 2381 19 transplantation transplantation NN cord-005453-4057qib7 2381 20 ( ( -LRB- cord-005453-4057qib7 2381 21 aHSCT aHSCT NNP cord-005453-4057qib7 2381 22 ) ) -RRB- cord-005453-4057qib7 2381 23 . . . cord-005453-4057qib7 2382 1 The the DT cord-005453-4057qib7 2382 2 choice choice NN cord-005453-4057qib7 2382 3 of of IN cord-005453-4057qib7 2382 4 optimal optimal JJ cord-005453-4057qib7 2382 5 conditioning conditioning NN cord-005453-4057qib7 2382 6 regimen regimen NN cord-005453-4057qib7 2382 7 for for IN cord-005453-4057qib7 2382 8 patients patient NNS cord-005453-4057qib7 2382 9 with with IN cord-005453-4057qib7 2382 10 JMML JMML NNP cord-005453-4057qib7 2382 11 is be VBZ cord-005453-4057qib7 2382 12 crucial crucial JJ cord-005453-4057qib7 2382 13 as as RB cord-005453-4057qib7 2382 14 well well RB cord-005453-4057qib7 2382 15 as as IN cord-005453-4057qib7 2382 16 long long JJ cord-005453-4057qib7 2382 17 - - HYPH cord-005453-4057qib7 2382 18 term term NN cord-005453-4057qib7 2382 19 observation observation NN cord-005453-4057qib7 2382 20 . . . cord-005453-4057qib7 2383 1 We -PRON- PRP cord-005453-4057qib7 2383 2 aimed aim VBD cord-005453-4057qib7 2383 3 to to TO cord-005453-4057qib7 2383 4 estimate estimate VB cord-005453-4057qib7 2383 5 the the DT cord-005453-4057qib7 2383 6 long long JJ cord-005453-4057qib7 2383 7 - - HYPH cord-005453-4057qib7 2383 8 term term NN cord-005453-4057qib7 2383 9 follow follow NN cord-005453-4057qib7 2383 10 - - HYPH cord-005453-4057qib7 2383 11 up up NN cord-005453-4057qib7 2383 12 and and CC cord-005453-4057qib7 2383 13 survival survival NN cord-005453-4057qib7 2383 14 rates rate NNS cord-005453-4057qib7 2383 15 of of IN cord-005453-4057qib7 2383 16 patients patient NNS cord-005453-4057qib7 2383 17 with with IN cord-005453-4057qib7 2383 18 JMML JMML NNP cord-005453-4057qib7 2383 19 after after IN cord-005453-4057qib7 2383 20 aHSCT ahsct NN cord-005453-4057qib7 2383 21 with with IN cord-005453-4057qib7 2383 22 the the DT cord-005453-4057qib7 2383 23 help help NN cord-005453-4057qib7 2383 24 of of IN cord-005453-4057qib7 2383 25 Busulfan Busulfan NNP cord-005453-4057qib7 2383 26 or or CC cord-005453-4057qib7 2383 27 Treosulfan Treosulfan NNP cord-005453-4057qib7 2383 28 - - HYPH cord-005453-4057qib7 2383 29 based base VBN cord-005453-4057qib7 2383 30 conditioning conditioning NN cord-005453-4057qib7 2383 31 regimens regimen NNS cord-005453-4057qib7 2383 32 . . . cord-005453-4057qib7 2384 1 Methods method NNS cord-005453-4057qib7 2384 2 : : : cord-005453-4057qib7 2385 1 Thirty thirty CD cord-005453-4057qib7 2385 2 eight eight CD cord-005453-4057qib7 2385 3 patients patient NNS cord-005453-4057qib7 2385 4 with with IN cord-005453-4057qib7 2385 5 JMML JMML NNP cord-005453-4057qib7 2385 6 underwent undergo VBD cord-005453-4057qib7 2385 7 aHSCT ahsct NN cord-005453-4057qib7 2385 8 in in IN cord-005453-4057qib7 2385 9 2002 2002 CD cord-005453-4057qib7 2385 10 - - SYM cord-005453-4057qib7 2385 11 2018 2018 CD cord-005453-4057qib7 2385 12 . . . cord-005453-4057qib7 2386 1 We -PRON- PRP cord-005453-4057qib7 2386 2 compared compare VBD cord-005453-4057qib7 2386 3 equal equal JJ cord-005453-4057qib7 2386 4 groups group NNS cord-005453-4057qib7 2386 5 of of IN cord-005453-4057qib7 2386 6 patients patient NNS cord-005453-4057qib7 2386 7 received receive VBD cord-005453-4057qib7 2386 8 Busulfan Busulfan NNP cord-005453-4057qib7 2386 9 ( ( -LRB- cord-005453-4057qib7 2386 10 n=19 n=19 NN cord-005453-4057qib7 2386 11 ) ) -RRB- cord-005453-4057qib7 2386 12 and and CC cord-005453-4057qib7 2386 13 Treosulfan Treosulfan NNP cord-005453-4057qib7 2386 14 - - HYPH cord-005453-4057qib7 2386 15 based base VBN cord-005453-4057qib7 2386 16 ( ( -LRB- cord-005453-4057qib7 2386 17 n=19 n=19 JJ cord-005453-4057qib7 2386 18 ) ) -RRB- cord-005453-4057qib7 2386 19 conditioning conditioning NN cord-005453-4057qib7 2386 20 regimen regimen NN cord-005453-4057qib7 2386 21 . . . cord-005453-4057qib7 2387 1 M M NNP cord-005453-4057qib7 2387 2 : : : cord-005453-4057qib7 2388 1 F=28:11 F=28:11 NNP cord-005453-4057qib7 2388 2 . . . cord-005453-4057qib7 2389 1 Median median NN cord-005453-4057qib7 2389 2 of of IN cord-005453-4057qib7 2389 3 age age NN cord-005453-4057qib7 2389 4 at at IN cord-005453-4057qib7 2389 5 HSCT HSCT NNP cord-005453-4057qib7 2389 6 was be VBD cord-005453-4057qib7 2389 7 2.5 2.5 CD cord-005453-4057qib7 2389 8 ( ( -LRB- cord-005453-4057qib7 2389 9 0.6 0.6 CD cord-005453-4057qib7 2389 10 - - SYM cord-005453-4057qib7 2389 11 5 5 CD cord-005453-4057qib7 2389 12 ) ) -RRB- cord-005453-4057qib7 2389 13 . . . cord-005453-4057qib7 2390 1 Donor donor NN cord-005453-4057qib7 2390 2 type type NN cord-005453-4057qib7 2390 3 : : : cord-005453-4057qib7 2390 4 HLA HLA NNP cord-005453-4057qib7 2390 5 - - HYPH cord-005453-4057qib7 2390 6 related relate VBN cord-005453-4057qib7 2390 7 10/10 10/10 CD cord-005453-4057qib7 2390 8 -29 -29 CD cord-005453-4057qib7 2390 9 % % NN cord-005453-4057qib7 2390 10 ( ( -LRB- cord-005453-4057qib7 2390 11 n=11 n=11 NNP cord-005453-4057qib7 2390 12 ) ) -RRB- cord-005453-4057qib7 2390 13 , , , cord-005453-4057qib7 2390 14 HLA HLA NNP cord-005453-4057qib7 2390 15 - - HYPH cord-005453-4057qib7 2390 16 related relate VBN cord-005453-4057qib7 2390 17 9/10 9/10 CD cord-005453-4057qib7 2390 18 -2.6 -2.6 CD cord-005453-4057qib7 2390 19 % % NN cord-005453-4057qib7 2390 20 ( ( -LRB- cord-005453-4057qib7 2390 21 n=1 n=1 CD cord-005453-4057qib7 2390 22 ) ) -RRB- cord-005453-4057qib7 2390 23 , , , cord-005453-4057qib7 2390 24 HLAunrelated HLAunrelated NNP cord-005453-4057qib7 2390 25 10/10 10/10 CD cord-005453-4057qib7 2390 26 -39.4 -39.4 CD cord-005453-4057qib7 2390 27 % % NN cord-005453-4057qib7 2390 28 ( ( -LRB- cord-005453-4057qib7 2390 29 n=15 n=15 NNP cord-005453-4057qib7 2390 30 ) ) -RRB- cord-005453-4057qib7 2390 31 , , , cord-005453-4057qib7 2390 32 HLA HLA NNP cord-005453-4057qib7 2390 33 - - HYPH cord-005453-4057qib7 2390 34 unrelated unrelated JJ cord-005453-4057qib7 2390 35 9/10 9/10 CD cord-005453-4057qib7 2390 36 -15.8 -15.8 CD cord-005453-4057qib7 2390 37 % % NN cord-005453-4057qib7 2390 38 ( ( -LRB- cord-005453-4057qib7 2390 39 n=6 n=6 NNP cord-005453-4057qib7 2390 40 ) ) -RRB- cord-005453-4057qib7 2390 41 , , , cord-005453-4057qib7 2390 42 and and CC cord-005453-4057qib7 2390 43 haploidentical haploidentical JJ cord-005453-4057qib7 2390 44 -13.2 -13.2 CD cord-005453-4057qib7 2390 45 % % NN cord-005453-4057qib7 2390 46 ( ( -LRB- cord-005453-4057qib7 2390 47 n=5 n=5 NNP cord-005453-4057qib7 2390 48 ) ) -RRB- cord-005453-4057qib7 2390 49 . . . cord-005453-4057qib7 2391 1 Stem stem JJ cord-005453-4057qib7 2391 2 cell cell NN cord-005453-4057qib7 2391 3 source source NN cord-005453-4057qib7 2391 4 : : : cord-005453-4057qib7 2391 5 BM BM NNP cord-005453-4057qib7 2391 6 -55.3 -55.3 CD cord-005453-4057qib7 2391 7 % % NN cord-005453-4057qib7 2391 8 ( ( -LRB- cord-005453-4057qib7 2391 9 n=21 n=21 NNP cord-005453-4057qib7 2391 10 ) ) -RRB- cord-005453-4057qib7 2391 11 , , , cord-005453-4057qib7 2391 12 PBSC PBSC NNP cord-005453-4057qib7 2391 13 -26.3 -26.3 DT cord-005453-4057qib7 2391 14 % % NN cord-005453-4057qib7 2391 15 ( ( -LRB- cord-005453-4057qib7 2391 16 n=10 n=10 NNP cord-005453-4057qib7 2391 17 ) ) -RRB- cord-005453-4057qib7 2391 18 , , , cord-005453-4057qib7 2391 19 UCB UCB NNP cord-005453-4057qib7 2391 20 -10,5 -10,5 NNP cord-005453-4057qib7 2391 21 % % NN cord-005453-4057qib7 2391 22 ( ( -LRB- cord-005453-4057qib7 2391 23 n=4 n=4 NNP cord-005453-4057qib7 2391 24 ) ) -RRB- cord-005453-4057qib7 2391 25 , , , cord-005453-4057qib7 2391 26 and and CC cord-005453-4057qib7 2391 27 UCB+BM UCB+BM NNP cord-005453-4057qib7 2391 28 -7.9 -7.9 HYPH cord-005453-4057qib7 2391 29 % % NN cord-005453-4057qib7 2391 30 ( ( -LRB- cord-005453-4057qib7 2391 31 n=3 n=3 NN cord-005453-4057qib7 2391 32 ) ) -RRB- cord-005453-4057qib7 2391 33 . . . cord-005453-4057qib7 2392 1 Disease disease NN cord-005453-4057qib7 2392 2 status status NN cord-005453-4057qib7 2392 3 on on IN cord-005453-4057qib7 2392 4 HSCT HSCT NNP cord-005453-4057qib7 2392 5 : : : cord-005453-4057qib7 2393 1 CR CR NNP cord-005453-4057qib7 2393 2 -73.7 -73.7 CD cord-005453-4057qib7 2393 3 % % NN cord-005453-4057qib7 2393 4 ( ( -LRB- cord-005453-4057qib7 2393 5 n=28 n=28 RB cord-005453-4057qib7 2393 6 ) ) -RRB- cord-005453-4057qib7 2393 7 , , , cord-005453-4057qib7 2393 8 Refractory Refractory NNP cord-005453-4057qib7 2393 9 -26.3 -26.3 NNP cord-005453-4057qib7 2393 10 % % NN cord-005453-4057qib7 2393 11 ( ( -LRB- cord-005453-4057qib7 2393 12 n=10 n=10 NNP cord-005453-4057qib7 2393 13 ) ) -RRB- cord-005453-4057qib7 2393 14 . . . cord-005453-4057qib7 2394 1 Results result NNS cord-005453-4057qib7 2394 2 : : : cord-005453-4057qib7 2395 1 Median median JJ cord-005453-4057qib7 2395 2 follow follow NN cord-005453-4057qib7 2395 3 - - HYPH cord-005453-4057qib7 2395 4 up up NN cord-005453-4057qib7 2395 5 15.5 15.5 CD cord-005453-4057qib7 2395 6 months month NNS cord-005453-4057qib7 2395 7 ( ( -LRB- cord-005453-4057qib7 2395 8 1 1 CD cord-005453-4057qib7 2395 9 - - SYM cord-005453-4057qib7 2395 10 129 129 CD cord-005453-4057qib7 2395 11 months month NNS cord-005453-4057qib7 2395 12 ) ) -RRB- cord-005453-4057qib7 2395 13 . . . cord-005453-4057qib7 2396 1 The the DT cord-005453-4057qib7 2396 2 estimated estimate VBN cord-005453-4057qib7 2396 3 10-year 10-year CD cord-005453-4057qib7 2396 4 overall overall JJ cord-005453-4057qib7 2396 5 survival survival NN cord-005453-4057qib7 2396 6 ( ( -LRB- cord-005453-4057qib7 2396 7 OS os NN cord-005453-4057qib7 2396 8 ) ) -RRB- cord-005453-4057qib7 2396 9 probability probability NN cord-005453-4057qib7 2396 10 in in IN cord-005453-4057qib7 2396 11 patients patient NNS cord-005453-4057qib7 2396 12 received receive VBD cord-005453-4057qib7 2396 13 Busulfan Busulfan NNP cord-005453-4057qib7 2396 14 - - HYPH cord-005453-4057qib7 2396 15 based base VBN cord-005453-4057qib7 2396 16 conditioning conditioning NN cord-005453-4057qib7 2396 17 was be VBD cord-005453-4057qib7 2396 18 48,8 48,8 CD cord-005453-4057qib7 2396 19 ±13,4 ±13,4 ADD cord-005453-4057qib7 2396 20 % % NN cord-005453-4057qib7 2396 21 in in IN cord-005453-4057qib7 2396 22 comparison comparison NN cord-005453-4057qib7 2396 23 with with IN cord-005453-4057qib7 2396 24 68,0±10,8 68,0±10,8 CD cord-005453-4057qib7 2396 25 % % NN cord-005453-4057qib7 2396 26 in in IN cord-005453-4057qib7 2396 27 patients patient NNS cord-005453-4057qib7 2396 28 with with IN cord-005453-4057qib7 2396 29 Treosulfan Treosulfan NNP cord-005453-4057qib7 2396 30 - - HYPH cord-005453-4057qib7 2396 31 based base VBN cord-005453-4057qib7 2396 32 regimen regimen NN cord-005453-4057qib7 2396 33 ( ( -LRB- cord-005453-4057qib7 2396 34 р=0,458 р=0,458 NNP cord-005453-4057qib7 2396 35 ) ) -RRB- cord-005453-4057qib7 2396 36 . . . cord-005453-4057qib7 2397 1 Event event NN cord-005453-4057qib7 2397 2 - - HYPH cord-005453-4057qib7 2397 3 free free JJ cord-005453-4057qib7 2397 4 survival survival NN cord-005453-4057qib7 2397 5 ( ( -LRB- cord-005453-4057qib7 2397 6 EFS EFS NNP cord-005453-4057qib7 2397 7 ) ) -RRB- cord-005453-4057qib7 2397 8 was be VBD cord-005453-4057qib7 2397 9 42,1±11,3 42,1±11,3 CD cord-005453-4057qib7 2397 10 % % NN cord-005453-4057qib7 2397 11 in in IN cord-005453-4057qib7 2397 12 group group NN cord-005453-4057qib7 2397 13 with with IN cord-005453-4057qib7 2397 14 Busulfan Busulfan NNP cord-005453-4057qib7 2397 15 - - HYPH cord-005453-4057qib7 2397 16 based base VBN cord-005453-4057qib7 2397 17 regimen regimen NN cord-005453-4057qib7 2397 18 and and CC cord-005453-4057qib7 2397 19 57,0±11,5 57,0±11,5 CD cord-005453-4057qib7 2397 20 % % NN cord-005453-4057qib7 2397 21 in in IN cord-005453-4057qib7 2397 22 patients patient NNS cord-005453-4057qib7 2397 23 with with IN cord-005453-4057qib7 2397 24 Treosulfanbased Treosulfanbased NNP cord-005453-4057qib7 2397 25 conditioning conditioning NN cord-005453-4057qib7 2397 26 ( ( -LRB- cord-005453-4057qib7 2397 27 р=0,224 р=0,224 NNP cord-005453-4057qib7 2397 28 ) ) -RRB- cord-005453-4057qib7 2397 29 . . . cord-005453-4057qib7 2398 1 Background background NN cord-005453-4057qib7 2398 2 : : : cord-005453-4057qib7 2399 1 Post post JJ cord-005453-4057qib7 2399 2 - - JJ cord-005453-4057qib7 2399 3 transplant transplant JJ cord-005453-4057qib7 2399 4 relapse relapse NN cord-005453-4057qib7 2399 5 remains remain VBZ cord-005453-4057qib7 2399 6 the the DT cord-005453-4057qib7 2399 7 leading leading JJ cord-005453-4057qib7 2399 8 cause cause NN cord-005453-4057qib7 2399 9 of of IN cord-005453-4057qib7 2399 10 treatment treatment NN cord-005453-4057qib7 2399 11 failure failure NN cord-005453-4057qib7 2399 12 in in IN cord-005453-4057qib7 2399 13 high high JJ cord-005453-4057qib7 2399 14 risk risk NN cord-005453-4057qib7 2399 15 ( ( -LRB- cord-005453-4057qib7 2399 16 HR HR NNP cord-005453-4057qib7 2399 17 ) ) -RRB- cord-005453-4057qib7 2399 18 acute acute JJ cord-005453-4057qib7 2399 19 myeloid myeloid NN cord-005453-4057qib7 2399 20 leukemia leukemia NN cord-005453-4057qib7 2399 21 ( ( -LRB- cord-005453-4057qib7 2399 22 AML AML NNP cord-005453-4057qib7 2399 23 ) ) -RRB- cord-005453-4057qib7 2399 24 , , , cord-005453-4057qib7 2399 25 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 2399 26 syndrome syndrome NN cord-005453-4057qib7 2399 27 ( ( -LRB- cord-005453-4057qib7 2399 28 MDS MDS NNP cord-005453-4057qib7 2399 29 ) ) -RRB- cord-005453-4057qib7 2399 30 , , . cord-005453-4057qib7 2400 1 myeloproliferative myeloproliferative NNP cord-005453-4057qib7 2400 2 neoplasia neoplasia NNP cord-005453-4057qib7 2400 3 ( ( -LRB- cord-005453-4057qib7 2400 4 MPNs mpn NNS cord-005453-4057qib7 2400 5 ) ) -RRB- cord-005453-4057qib7 2400 6 receiving receive VBG cord-005453-4057qib7 2400 7 allogeneic allogeneic JJ cord-005453-4057qib7 2400 8 hematopoietic hematopoietic JJ cord-005453-4057qib7 2400 9 cell cell NN cord-005453-4057qib7 2400 10 transplantation transplantation NN cord-005453-4057qib7 2400 11 ( ( -LRB- cord-005453-4057qib7 2400 12 allo allo NN cord-005453-4057qib7 2400 13 - - HYPH cord-005453-4057qib7 2400 14 HCT HCT NNP cord-005453-4057qib7 2400 15 ) ) -RRB- cord-005453-4057qib7 2400 16 , , , cord-005453-4057qib7 2400 17 especially especially RB cord-005453-4057qib7 2400 18 for for IN cord-005453-4057qib7 2400 19 patients patient NNS cord-005453-4057qib7 2400 20 with with IN cord-005453-4057qib7 2400 21 relapsed relapsed JJ cord-005453-4057qib7 2400 22 or or CC cord-005453-4057qib7 2400 23 refractory refractory JJ cord-005453-4057qib7 2400 24 AML AML NNP cord-005453-4057qib7 2400 25 . . . cord-005453-4057qib7 2401 1 Recently recently RB cord-005453-4057qib7 2401 2 , , , cord-005453-4057qib7 2401 3 a a DT cord-005453-4057qib7 2401 4 sequential sequential JJ cord-005453-4057qib7 2401 5 transplant transplant NN cord-005453-4057qib7 2401 6 approach approach NN cord-005453-4057qib7 2401 7 , , , cord-005453-4057qib7 2401 8 as as IN cord-005453-4057qib7 2401 9 developed develop VBN cord-005453-4057qib7 2401 10 by by IN cord-005453-4057qib7 2401 11 the the DT cord-005453-4057qib7 2401 12 Munich Munich NNP cord-005453-4057qib7 2401 13 group group NN cord-005453-4057qib7 2401 14 , , , cord-005453-4057qib7 2401 15 comprising comprise VBG cord-005453-4057qib7 2401 16 of of IN cord-005453-4057qib7 2401 17 intensive intensive JJ cord-005453-4057qib7 2401 18 cytoreductive cytoreductive JJ cord-005453-4057qib7 2401 19 chemotherapy chemotherapy NN cord-005453-4057qib7 2401 20 FLAMSA FLAMSA NNP cord-005453-4057qib7 2401 21 ( ( -LRB- cord-005453-4057qib7 2401 22 Fludarabine Fludarabine NNP cord-005453-4057qib7 2401 23 / / SYM cord-005453-4057qib7 2401 24 Amsacrine Amsacrine NNP cord-005453-4057qib7 2401 25 / / SYM cord-005453-4057qib7 2401 26 cytarabine cytarabine NNP cord-005453-4057qib7 2401 27 ) ) -RRB- cord-005453-4057qib7 2401 28 to to TO cord-005453-4057qib7 2401 29 decrease decrease VB cord-005453-4057qib7 2401 30 leukemia leukemia NN cord-005453-4057qib7 2401 31 cell cell NN cord-005453-4057qib7 2401 32 burden burden NN cord-005453-4057qib7 2401 33 shortly shortly RB cord-005453-4057qib7 2401 34 prior prior RB cord-005453-4057qib7 2401 35 to to IN cord-005453-4057qib7 2401 36 conditioning conditioning NN cord-005453-4057qib7 2401 37 regimen regimen NN cord-005453-4057qib7 2401 38 , , , cord-005453-4057qib7 2401 39 has have VBZ cord-005453-4057qib7 2401 40 been be VBN cord-005453-4057qib7 2401 41 successfully successfully RB cord-005453-4057qib7 2401 42 used use VBN cord-005453-4057qib7 2401 43 for for IN cord-005453-4057qib7 2401 44 high high JJ cord-005453-4057qib7 2401 45 - - HYPH cord-005453-4057qib7 2401 46 risk risk NN cord-005453-4057qib7 2401 47 ( ( -LRB- cord-005453-4057qib7 2401 48 HR HR NNP cord-005453-4057qib7 2401 49 ) ) -RRB- cord-005453-4057qib7 2401 50 AML AML NNP cord-005453-4057qib7 2401 51 / / SYM cord-005453-4057qib7 2401 52 MDS MDS NNP cord-005453-4057qib7 2401 53 with with IN cord-005453-4057qib7 2401 54 promising promising JJ cord-005453-4057qib7 2401 55 results result NNS cord-005453-4057qib7 2401 56 . . . cord-005453-4057qib7 2402 1 Methods method NNS cord-005453-4057qib7 2402 2 : : : cord-005453-4057qib7 2402 3 We -PRON- PRP cord-005453-4057qib7 2402 4 studied study VBD cord-005453-4057qib7 2402 5 48 48 CD cord-005453-4057qib7 2402 6 patients patient NNS cord-005453-4057qib7 2402 7 ( ( -LRB- cord-005453-4057qib7 2402 8 median median JJ cord-005453-4057qib7 2402 9 age age NN cord-005453-4057qib7 2402 10 53 53 CD cord-005453-4057qib7 2402 11 years year NNS cord-005453-4057qib7 2402 12 , , , cord-005453-4057qib7 2402 13 range range VBP cord-005453-4057qib7 2402 14 26 26 CD cord-005453-4057qib7 2402 15 -68 -68 NNP cord-005453-4057qib7 2402 16 ) ) -RRB- cord-005453-4057qib7 2402 17 with with IN cord-005453-4057qib7 2402 18 HR HR NNP cord-005453-4057qib7 2402 19 AML AML NNP cord-005453-4057qib7 2402 20 ( ( -LRB- cord-005453-4057qib7 2402 21 n=38 n=38 NNP cord-005453-4057qib7 2402 22 ) ) -RRB- cord-005453-4057qib7 2402 23 , , , cord-005453-4057qib7 2402 24 as as IN cord-005453-4057qib7 2402 25 defined define VBN cord-005453-4057qib7 2402 26 by by IN cord-005453-4057qib7 2402 27 refractory refractory JJ cord-005453-4057qib7 2402 28 , , , cord-005453-4057qib7 2402 29 relapsed relapsed JJ cord-005453-4057qib7 2402 30 disease disease NN cord-005453-4057qib7 2402 31 , , , cord-005453-4057qib7 2402 32 secondary secondary JJ cord-005453-4057qib7 2402 33 leukemia leukemia NN cord-005453-4057qib7 2402 34 , , , cord-005453-4057qib7 2402 35 or or CC cord-005453-4057qib7 2402 36 high/ high/ ADD cord-005453-4057qib7 2402 37 very very JJ cord-005453-4057qib7 2402 38 risk risk NN cord-005453-4057qib7 2402 39 disease disease NN cord-005453-4057qib7 2402 40 risk risk NN cord-005453-4057qib7 2402 41 index index NN cord-005453-4057qib7 2402 42 risk risk NN cord-005453-4057qib7 2402 43 , , , cord-005453-4057qib7 2402 44 and and CC cord-005453-4057qib7 2402 45 HR HR NNP cord-005453-4057qib7 2402 46 MDS MDS NNP cord-005453-4057qib7 2402 47 ( ( -LRB- cord-005453-4057qib7 2402 48 n=10 n=10 NNP cord-005453-4057qib7 2402 49 ) ) -RRB- cord-005453-4057qib7 2402 50 according accord VBG cord-005453-4057qib7 2402 51 to to IN cord-005453-4057qib7 2402 52 IPSS IPSS NNP cord-005453-4057qib7 2402 53 - - HYPH cord-005453-4057qib7 2402 54 R R NNP cord-005453-4057qib7 2402 55 , , , cord-005453-4057qib7 2402 56 undergoing undergo VBG cord-005453-4057qib7 2402 57 allo allo NN cord-005453-4057qib7 2402 58 - - HYPH cord-005453-4057qib7 2402 59 HCT hct NN cord-005453-4057qib7 2402 60 using use VBG cord-005453-4057qib7 2402 61 the the DT cord-005453-4057qib7 2402 62 sequential sequential JJ cord-005453-4057qib7 2402 63 transplant transplant NN cord-005453-4057qib7 2402 64 approach approach NN cord-005453-4057qib7 2402 65 in in IN cord-005453-4057qib7 2402 66 2 2 CD cord-005453-4057qib7 2402 67 institutions institution NNS cord-005453-4057qib7 2402 68 between between IN cord-005453-4057qib7 2402 69 January January NNP cord-005453-4057qib7 2402 70 2009 2009 CD cord-005453-4057qib7 2402 71 and and CC cord-005453-4057qib7 2402 72 October October NNP cord-005453-4057qib7 2402 73 2018 2018 CD cord-005453-4057qib7 2402 74 . . . cord-005453-4057qib7 2403 1 The the DT cord-005453-4057qib7 2403 2 sequential sequential JJ cord-005453-4057qib7 2403 3 transplant transplant NN cord-005453-4057qib7 2403 4 approach approach NN cord-005453-4057qib7 2403 5 combined combine VBD cord-005453-4057qib7 2403 6 a a DT cord-005453-4057qib7 2403 7 cytoreductive cytoreductive JJ cord-005453-4057qib7 2403 8 chemotherapy chemotherapy NN cord-005453-4057qib7 2403 9 , , , cord-005453-4057qib7 2403 10 which which WDT cord-005453-4057qib7 2403 11 consisted consist VBD cord-005453-4057qib7 2403 12 of of IN cord-005453-4057qib7 2403 13 either either DT cord-005453-4057qib7 2403 14 FLAMSA FLAMSA NNP cord-005453-4057qib7 2403 15 ( ( -LRB- cord-005453-4057qib7 2403 16 n=17 n=17 NNP cord-005453-4057qib7 2403 17 ) ) -RRB- cord-005453-4057qib7 2403 18 , , , cord-005453-4057qib7 2403 19 FLAG flag NN cord-005453-4057qib7 2403 20 + + CC cord-005453-4057qib7 2403 21 /-Ida /-Ida . cord-005453-4057qib7 2403 22 ( ( -LRB- cord-005453-4057qib7 2403 23 fludarabine fludarabine NNP cord-005453-4057qib7 2403 24 / / SYM cord-005453-4057qib7 2403 25 cytarabine cytarabine NNP cord-005453-4057qib7 2403 26 / / SYM cord-005453-4057qib7 2403 27 Granulocyte Granulocyte NNP cord-005453-4057qib7 2403 28 colony colony NN cord-005453-4057qib7 2403 29 stimulating stimulate VBG cord-005453-4057qib7 2403 30 factor factor NN cord-005453-4057qib7 2403 31 /Idarubicin /Idarubicin . cord-005453-4057qib7 2403 32 ) ) -RRB- cord-005453-4057qib7 2403 33 ( ( -LRB- cord-005453-4057qib7 2403 34 n=23 n=23 NNP cord-005453-4057qib7 2403 35 ) ) -RRB- cord-005453-4057qib7 2403 36 , , , cord-005453-4057qib7 2403 37 or or CC cord-005453-4057qib7 2403 38 Clo Clo NNP cord-005453-4057qib7 2403 39 - - HYPH cord-005453-4057qib7 2403 40 AraC AraC NNP cord-005453-4057qib7 2404 1 ( ( -LRB- cord-005453-4057qib7 2404 2 Clofarabine Clofarabine NNP cord-005453-4057qib7 2404 3 / / SYM cord-005453-4057qib7 2404 4 Cytarabine Cytarabine NNP cord-005453-4057qib7 2404 5 ) ) -RRB- cord-005453-4057qib7 2404 6 ( ( -LRB- cord-005453-4057qib7 2404 7 n=8 n=8 NN cord-005453-4057qib7 2404 8 ) ) -RRB- cord-005453-4057qib7 2404 9 , , , cord-005453-4057qib7 2404 10 followed follow VBN cord-005453-4057qib7 2404 11 by by IN cord-005453-4057qib7 2404 12 reduced reduce VBN cord-005453-4057qib7 2404 13 ( ( -LRB- cord-005453-4057qib7 2404 14 RIC RIC NNP cord-005453-4057qib7 2404 15 ) ) -RRB- cord-005453-4057qib7 2404 16 ( ( -LRB- cord-005453-4057qib7 2404 17 N=43 N=43 NNP cord-005453-4057qib7 2404 18 ) ) -RRB- cord-005453-4057qib7 2404 19 or or CC cord-005453-4057qib7 2404 20 myeloablative myeloablative NNP cord-005453-4057qib7 2404 21 ( ( -LRB- cord-005453-4057qib7 2404 22 MAC MAC NNP cord-005453-4057qib7 2404 23 ) ) -RRB- cord-005453-4057qib7 2405 1 ( ( -LRB- cord-005453-4057qib7 2405 2 N=5 N=5 NNP cord-005453-4057qib7 2405 3 ) ) -RRB- cord-005453-4057qib7 2405 4 conditioning conditioning NN cord-005453-4057qib7 2405 5 regimen regimen NN cord-005453-4057qib7 2405 6 . . . cord-005453-4057qib7 2406 1 All all DT cord-005453-4057qib7 2406 2 patients patient NNS cord-005453-4057qib7 2406 3 received receive VBD cord-005453-4057qib7 2406 4 peripheral peripheral JJ cord-005453-4057qib7 2406 5 blood blood NN cord-005453-4057qib7 2406 6 stem stem NN cord-005453-4057qib7 2406 7 cell cell NN cord-005453-4057qib7 2406 8 from from IN cord-005453-4057qib7 2406 9 matched match VBN cord-005453-4057qib7 2406 10 related related JJ cord-005453-4057qib7 2406 11 donors donor NNS cord-005453-4057qib7 2406 12 ( ( -LRB- cord-005453-4057qib7 2406 13 N=27 N=27 NNP cord-005453-4057qib7 2406 14 ) ) -RRB- cord-005453-4057qib7 2406 15 matched match VBD cord-005453-4057qib7 2406 16 unrelated unrelated JJ cord-005453-4057qib7 2406 17 donors donor NNS cord-005453-4057qib7 2406 18 ( ( -LRB- cord-005453-4057qib7 2406 19 N=14 N=14 NNP cord-005453-4057qib7 2406 20 ) ) -RRB- cord-005453-4057qib7 2406 21 , , , cord-005453-4057qib7 2406 22 or or CC cord-005453-4057qib7 2406 23 mismatched mismatch VBN cord-005453-4057qib7 2406 24 unrelated unrelated JJ cord-005453-4057qib7 2406 25 donors donor NNS cord-005453-4057qib7 2406 26 ( ( -LRB- cord-005453-4057qib7 2406 27 N=7 N=7 NNP cord-005453-4057qib7 2406 28 ) ) -RRB- cord-005453-4057qib7 2406 29 . . . cord-005453-4057qib7 2407 1 Post post JJ cord-005453-4057qib7 2407 2 - - JJ cord-005453-4057qib7 2407 3 grafting graft VBG cord-005453-4057qib7 2407 4 immunosuppression immunosuppression NN cord-005453-4057qib7 2407 5 consisted consist VBD cord-005453-4057qib7 2407 6 of of IN cord-005453-4057qib7 2407 7 calcineurin calcineurin NNP cord-005453-4057qib7 2407 8 inhibitor inhibitor NN cord-005453-4057qib7 2407 9 and and CC cord-005453-4057qib7 2407 10 mycophenolate mycophenolate NNP cord-005453-4057qib7 2407 11 mofetil mofetil NNP cord-005453-4057qib7 2407 12 in in IN cord-005453-4057qib7 2407 13 all all DT cord-005453-4057qib7 2407 14 patients patient NNS cord-005453-4057qib7 2407 15 . . . cord-005453-4057qib7 2408 1 Thymoglobulin Thymoglobulin NNP cord-005453-4057qib7 2408 2 was be VBD cord-005453-4057qib7 2408 3 added add VBN cord-005453-4057qib7 2408 4 for for IN cord-005453-4057qib7 2408 5 GVHD GVHD NNP cord-005453-4057qib7 2408 6 prophylaxis prophylaxis NN cord-005453-4057qib7 2408 7 for for IN cord-005453-4057qib7 2408 8 unrelated unrelated JJ cord-005453-4057qib7 2408 9 donor donor NN cord-005453-4057qib7 2408 10 transplant transplant NN cord-005453-4057qib7 2408 11 . . . cord-005453-4057qib7 2409 1 Results result NNS cord-005453-4057qib7 2409 2 : : : cord-005453-4057qib7 2410 1 The the DT cord-005453-4057qib7 2410 2 median median JJ cord-005453-4057qib7 2410 3 time time NN cord-005453-4057qib7 2410 4 to to IN cord-005453-4057qib7 2410 5 neutrophil neutrophil NN cord-005453-4057qib7 2410 6 > > XX cord-005453-4057qib7 2411 1 1000 1000 CD cord-005453-4057qib7 2412 1 /μL /μL : cord-005453-4057qib7 2412 2 was be VBD cord-005453-4057qib7 2412 3 10 10 CD cord-005453-4057qib7 2412 4 days day NNS cord-005453-4057qib7 2412 5 ( ( -LRB- cord-005453-4057qib7 2412 6 range range NN cord-005453-4057qib7 2412 7 , , , cord-005453-4057qib7 2412 8 9 9 CD cord-005453-4057qib7 2412 9 - - SYM cord-005453-4057qib7 2412 10 25 25 CD cord-005453-4057qib7 2412 11 ) ) -RRB- cord-005453-4057qib7 2412 12 . . . cord-005453-4057qib7 2413 1 With with IN cord-005453-4057qib7 2413 2 a a DT cord-005453-4057qib7 2413 3 median median JJ cord-005453-4057qib7 2413 4 follow follow NN cord-005453-4057qib7 2413 5 - - HYPH cord-005453-4057qib7 2413 6 up up NN cord-005453-4057qib7 2413 7 of of IN cord-005453-4057qib7 2413 8 28.2 28.2 CD cord-005453-4057qib7 2413 9 months month NNS cord-005453-4057qib7 2413 10 ( ( -LRB- cord-005453-4057qib7 2413 11 range range NN cord-005453-4057qib7 2413 12 , , , cord-005453-4057qib7 2413 13 1.4 1.4 CD cord-005453-4057qib7 2413 14 to to IN cord-005453-4057qib7 2413 15 103.1 103.1 CD cord-005453-4057qib7 2413 16 months month NNS cord-005453-4057qib7 2413 17 ) ) -RRB- cord-005453-4057qib7 2413 18 , , , cord-005453-4057qib7 2413 19 the the DT cord-005453-4057qib7 2413 20 Kaplan Kaplan NNP cord-005453-4057qib7 2413 21 - - HYPH cord-005453-4057qib7 2413 22 Meier Meier NNP cord-005453-4057qib7 2413 23 estimate estimate NN cord-005453-4057qib7 2413 24 of of IN cord-005453-4057qib7 2413 25 leukemia leukemia NN cord-005453-4057qib7 2413 26 - - HYPH cord-005453-4057qib7 2413 27 free free JJ cord-005453-4057qib7 2413 28 ( ( -LRB- cord-005453-4057qib7 2413 29 LFS lfs NN cord-005453-4057qib7 2413 30 ) ) -RRB- cord-005453-4057qib7 2413 31 and and CC cord-005453-4057qib7 2413 32 overall overall JJ cord-005453-4057qib7 2413 33 survival survival NN cord-005453-4057qib7 2413 34 ( ( -LRB- cord-005453-4057qib7 2413 35 OS OS NNP cord-005453-4057qib7 2413 36 ) ) -RRB- cord-005453-4057qib7 2413 37 at at IN cord-005453-4057qib7 2413 38 5 5 CD cord-005453-4057qib7 2413 39 years year NNS cord-005453-4057qib7 2413 40 were be VBD cord-005453-4057qib7 2413 41 45 45 CD cord-005453-4057qib7 2413 42 % % NN cord-005453-4057qib7 2413 43 ( ( -LRB- cord-005453-4057qib7 2413 44 95 95 CD cord-005453-4057qib7 2413 45 % % NN cord-005453-4057qib7 2413 46 CI ci NN cord-005453-4057qib7 2413 47 , , , cord-005453-4057qib7 2413 48 8 8 CD cord-005453-4057qib7 2413 49 - - SYM cord-005453-4057qib7 2413 50 30 30 CD cord-005453-4057qib7 2413 51 ) ) -RRB- cord-005453-4057qib7 2413 52 , , , cord-005453-4057qib7 2413 53 46 46 CD cord-005453-4057qib7 2413 54 % % NN cord-005453-4057qib7 2413 55 ( ( -LRB- cord-005453-4057qib7 2413 56 95 95 CD cord-005453-4057qib7 2413 57 % % NN cord-005453-4057qib7 2413 58 CI ci NN cord-005453-4057qib7 2413 59 , , , cord-005453-4057qib7 2413 60 8 8 CD cord-005453-4057qib7 2413 61 - - SYM cord-005453-4057qib7 2413 62 30 30 CD cord-005453-4057qib7 2413 63 ) ) -RRB- cord-005453-4057qib7 2413 64 , , , cord-005453-4057qib7 2413 65 respectively respectively RB cord-005453-4057qib7 2413 66 . . . cord-005453-4057qib7 2414 1 Patients patient NNS cord-005453-4057qib7 2414 2 receiving receive VBG cord-005453-4057qib7 2414 3 FLAG flag NN cord-005453-4057qib7 2414 4 or or CC cord-005453-4057qib7 2414 5 Clo Clo NNP cord-005453-4057qib7 2414 6 - - HYPH cord-005453-4057qib7 2414 7 AraC AraC NNP cord-005453-4057qib7 2414 8 based base VBD cord-005453-4057qib7 2414 9 sequential sequential JJ cord-005453-4057qib7 2414 10 regimen regimen NN cord-005453-4057qib7 2414 11 showed show VBD cord-005453-4057qib7 2414 12 a a DT cord-005453-4057qib7 2414 13 trend trend NN cord-005453-4057qib7 2414 14 towards towards IN cord-005453-4057qib7 2414 15 more more RBR cord-005453-4057qib7 2414 16 favourable favourable JJ cord-005453-4057qib7 2414 17 overall overall JJ cord-005453-4057qib7 2414 18 survival survival NN cord-005453-4057qib7 2414 19 ( ( -LRB- cord-005453-4057qib7 2414 20 OS OS NNP cord-005453-4057qib7 2414 21 ) ) -RRB- cord-005453-4057qib7 2414 22 as as IN cord-005453-4057qib7 2414 23 compared compare VBN cord-005453-4057qib7 2414 24 to to IN cord-005453-4057qib7 2414 25 patients patient NNS cord-005453-4057qib7 2414 26 given give VBN cord-005453-4057qib7 2414 27 FLAMSA FLAMSA NNP cord-005453-4057qib7 2414 28 ( ( -LRB- cord-005453-4057qib7 2414 29 5 5 CD cord-005453-4057qib7 2414 30 year year NN cord-005453-4057qib7 2414 31 OS os NN cord-005453-4057qib7 2414 32 : : : cord-005453-4057qib7 2414 33 53 53 CD cord-005453-4057qib7 2414 34 % % NN cord-005453-4057qib7 2414 35 vs vs IN cord-005453-4057qib7 2414 36 31 31 CD cord-005453-4057qib7 2414 37 % % NN cord-005453-4057qib7 2414 38 ; ; : cord-005453-4057qib7 2414 39 p=0.236 p=0.236 NNP cord-005453-4057qib7 2414 40 ) ) -RRB- cord-005453-4057qib7 2414 41 . . . cord-005453-4057qib7 2415 1 At at IN cord-005453-4057qib7 2415 2 2 2 CD cord-005453-4057qib7 2415 3 years year NNS cord-005453-4057qib7 2415 4 , , , cord-005453-4057qib7 2415 5 the the DT cord-005453-4057qib7 2415 6 cumulative cumulative JJ cord-005453-4057qib7 2415 7 incidences incidence NNS cord-005453-4057qib7 2415 8 of of IN cord-005453-4057qib7 2415 9 relapse relapse NN cord-005453-4057qib7 2415 10 and and CC cord-005453-4057qib7 2415 11 non non JJ cord-005453-4057qib7 2415 12 - - JJ cord-005453-4057qib7 2415 13 relapse relapse JJ cord-005453-4057qib7 2415 14 mortality mortality NN cord-005453-4057qib7 2415 15 ( ( -LRB- cord-005453-4057qib7 2415 16 NRM NRM NNP cord-005453-4057qib7 2415 17 ) ) -RRB- cord-005453-4057qib7 2415 18 were be VBD cord-005453-4057qib7 2415 19 46 46 CD cord-005453-4057qib7 2415 20 % % NN cord-005453-4057qib7 2415 21 ( ( -LRB- cord-005453-4057qib7 2415 22 95 95 CD cord-005453-4057qib7 2415 23 % % NN cord-005453-4057qib7 2415 24 CI CI NNP cord-005453-4057qib7 2415 25 , , , cord-005453-4057qib7 2415 26 31 31 CD cord-005453-4057qib7 2415 27 - - SYM cord-005453-4057qib7 2415 28 60 60 CD cord-005453-4057qib7 2415 29 % % NN cord-005453-4057qib7 2415 30 ) ) -RRB- cord-005453-4057qib7 2415 31 and and CC cord-005453-4057qib7 2415 32 15 15 CD cord-005453-4057qib7 2415 33 % % NN cord-005453-4057qib7 2415 34 ( ( -LRB- cord-005453-4057qib7 2415 35 95 95 CD cord-005453-4057qib7 2415 36 % % NN cord-005453-4057qib7 2415 37 CI CI NNP cord-005453-4057qib7 2415 38 , , , cord-005453-4057qib7 2415 39 7 7 CD cord-005453-4057qib7 2415 40 - - SYM cord-005453-4057qib7 2415 41 21 21 CD cord-005453-4057qib7 2415 42 % % NN cord-005453-4057qib7 2415 43 ) ) -RRB- cord-005453-4057qib7 2415 44 , , , cord-005453-4057qib7 2415 45 respectively respectively RB cord-005453-4057qib7 2415 46 . . . cord-005453-4057qib7 2416 1 In in IN cord-005453-4057qib7 2416 2 multivariate multivariate JJ cord-005453-4057qib7 2416 3 analysis analysis NN cord-005453-4057qib7 2416 4 , , , cord-005453-4057qib7 2416 5 the the DT cord-005453-4057qib7 2416 6 type type NN cord-005453-4057qib7 2416 7 of of IN cord-005453-4057qib7 2416 8 sequential sequential JJ cord-005453-4057qib7 2416 9 conditioning conditioning NN cord-005453-4057qib7 2416 10 regimen regimen NN cord-005453-4057qib7 2416 11 did do VBD cord-005453-4057qib7 2416 12 not not RB cord-005453-4057qib7 2416 13 show show VB cord-005453-4057qib7 2416 14 any any DT cord-005453-4057qib7 2416 15 significant significant JJ cord-005453-4057qib7 2416 16 impact impact NN cord-005453-4057qib7 2416 17 on on IN cord-005453-4057qib7 2416 18 LFS lfs NN cord-005453-4057qib7 2416 19 , , , cord-005453-4057qib7 2416 20 OS OS NNP cord-005453-4057qib7 2416 21 , , , cord-005453-4057qib7 2416 22 NRM NRM NNP cord-005453-4057qib7 2416 23 or or CC cord-005453-4057qib7 2416 24 relapse relapse NN cord-005453-4057qib7 2416 25 . . . cord-005453-4057qib7 2417 1 Conclusions conclusion NNS cord-005453-4057qib7 2417 2 : : : cord-005453-4057qib7 2418 1 Sequential sequential JJ cord-005453-4057qib7 2418 2 transplant transplant NN cord-005453-4057qib7 2418 3 conditioning conditioning NN cord-005453-4057qib7 2418 4 with with IN cord-005453-4057qib7 2418 5 FLAMSA FLAMSA NNP cord-005453-4057qib7 2418 6 , , , cord-005453-4057qib7 2418 7 FLAG flag NN cord-005453-4057qib7 2418 8 or or CC cord-005453-4057qib7 2418 9 Clo Clo NNP cord-005453-4057qib7 2418 10 - - HYPH cord-005453-4057qib7 2418 11 AraC AraC NNP cord-005453-4057qib7 2418 12 followed follow VBD cord-005453-4057qib7 2418 13 by by IN cord-005453-4057qib7 2418 14 allo allo NN cord-005453-4057qib7 2418 15 - - HYPH cord-005453-4057qib7 2418 16 HCT HCT NNP cord-005453-4057qib7 2418 17 is be VBZ cord-005453-4057qib7 2418 18 an an DT cord-005453-4057qib7 2418 19 effective effective JJ cord-005453-4057qib7 2418 20 strategy strategy NN cord-005453-4057qib7 2418 21 in in IN cord-005453-4057qib7 2418 22 overcoming overcome VBG cord-005453-4057qib7 2418 23 the the DT cord-005453-4057qib7 2418 24 dismal dismal JJ cord-005453-4057qib7 2418 25 prognosis prognosis NN cord-005453-4057qib7 2418 26 of of IN cord-005453-4057qib7 2418 27 HR HR NNP cord-005453-4057qib7 2418 28 AML AML NNP cord-005453-4057qib7 2418 29 and and CC cord-005453-4057qib7 2418 30 MDS MDS NNP cord-005453-4057qib7 2418 31 , , , cord-005453-4057qib7 2418 32 and and CC cord-005453-4057qib7 2418 33 enabling enable VBG cord-005453-4057qib7 2418 34 long long JJ cord-005453-4057qib7 2418 35 - - HYPH cord-005453-4057qib7 2418 36 term term NN cord-005453-4057qib7 2418 37 disease disease NN cord-005453-4057qib7 2418 38 free free JJ cord-005453-4057qib7 2418 39 survival survival NN cord-005453-4057qib7 2418 40 . . . cord-005453-4057qib7 2419 1 More More JJR cord-005453-4057qib7 2419 2 studies study NNS cord-005453-4057qib7 2419 3 on on IN cord-005453-4057qib7 2419 4 effective effective JJ cord-005453-4057qib7 2419 5 strategies strategy NNS cord-005453-4057qib7 2419 6 such such JJ cord-005453-4057qib7 2419 7 as as IN cord-005453-4057qib7 2419 8 posttransplant posttransplant NN cord-005453-4057qib7 2419 9 maintenance maintenance NN cord-005453-4057qib7 2419 10 therapy therapy NN cord-005453-4057qib7 2419 11 of of IN cord-005453-4057qib7 2419 12 prophylactic prophylactic JJ cord-005453-4057qib7 2419 13 donor donor NN cord-005453-4057qib7 2419 14 lymphocyte lymphocyte NN cord-005453-4057qib7 2419 15 infusion infusion NN cord-005453-4057qib7 2419 16 , , , cord-005453-4057qib7 2419 17 are be VBP cord-005453-4057qib7 2419 18 needed need VBN cord-005453-4057qib7 2419 19 to to TO cord-005453-4057qib7 2419 20 further further RB cord-005453-4057qib7 2419 21 eliminate eliminate VB cord-005453-4057qib7 2419 22 the the DT cord-005453-4057qib7 2419 23 risk risk NN cord-005453-4057qib7 2419 24 of of IN cord-005453-4057qib7 2419 25 relapse relapse NN cord-005453-4057qib7 2419 26 , , , cord-005453-4057qib7 2419 27 without without IN cord-005453-4057qib7 2419 28 increasing increase VBG cord-005453-4057qib7 2419 29 risk risk NN cord-005453-4057qib7 2419 30 of of IN cord-005453-4057qib7 2419 31 treatment treatment NN cord-005453-4057qib7 2419 32 related relate VBN cord-005453-4057qib7 2419 33 toxicity toxicity NN cord-005453-4057qib7 2419 34 . . . cord-005453-4057qib7 2420 1 Disclosure disclosure NN cord-005453-4057qib7 2420 2 : : : cord-005453-4057qib7 2420 3 Nothing nothing NN cord-005453-4057qib7 2420 4 to to TO cord-005453-4057qib7 2420 5 declare declare VB cord-005453-4057qib7 2420 6 Optimization optimization NN cord-005453-4057qib7 2420 7 of of IN cord-005453-4057qib7 2420 8 the the DT cord-005453-4057qib7 2420 9 blood blood NN cord-005453-4057qib7 2420 10 sampling sampling NN cord-005453-4057qib7 2420 11 procedure procedure NN cord-005453-4057qib7 2420 12 for for IN cord-005453-4057qib7 2420 13 busulfan busulfan NN cord-005453-4057qib7 2420 14 therapeutic therapeutic JJ cord-005453-4057qib7 2420 15 drug drug NN cord-005453-4057qib7 2420 16 monitoring monitoring NN cord-005453-4057qib7 2420 17 ( ( -LRB- cord-005453-4057qib7 2420 18 TDM tdm NN cord-005453-4057qib7 2420 19 ) ) -RRB- cord-005453-4057qib7 2420 20 To to TO cord-005453-4057qib7 2420 21 optimize optimize VB cord-005453-4057qib7 2420 22 our -PRON- PRP$ cord-005453-4057qib7 2420 23 sampling sampling NN cord-005453-4057qib7 2420 24 scheme scheme NN cord-005453-4057qib7 2420 25 ( ( -LRB- cord-005453-4057qib7 2420 26 15 15 CD cord-005453-4057qib7 2420 27 minutes minute NNS cord-005453-4057qib7 2420 28 , , , cord-005453-4057qib7 2420 29 1 1 CD cord-005453-4057qib7 2420 30 , , , cord-005453-4057qib7 2420 31 2 2 CD cord-005453-4057qib7 2420 32 , , , cord-005453-4057qib7 2420 33 3 3 CD cord-005453-4057qib7 2420 34 , , , cord-005453-4057qib7 2420 35 4 4 CD cord-005453-4057qib7 2420 36 , , , cord-005453-4057qib7 2420 37 6 6 CD cord-005453-4057qib7 2420 38 , , , cord-005453-4057qib7 2420 39 8 8 CD cord-005453-4057qib7 2420 40 and and CC cord-005453-4057qib7 2420 41 10 10 CD cord-005453-4057qib7 2420 42 hours hour NNS cord-005453-4057qib7 2420 43 after after IN cord-005453-4057qib7 2420 44 the the DT cord-005453-4057qib7 2420 45 end end NN cord-005453-4057qib7 2420 46 of of IN cord-005453-4057qib7 2420 47 a a DT cord-005453-4057qib7 2420 48 3-hour 3-hour CD cord-005453-4057qib7 2420 49 infusion infusion NN cord-005453-4057qib7 2420 50 ) ) -RRB- cord-005453-4057qib7 2421 1 , , , cord-005453-4057qib7 2421 2 we -PRON- PRP cord-005453-4057qib7 2421 3 reduced reduce VBD cord-005453-4057qib7 2421 4 the the DT cord-005453-4057qib7 2421 5 number number NN cord-005453-4057qib7 2421 6 of of IN cord-005453-4057qib7 2421 7 blood blood NN cord-005453-4057qib7 2421 8 samples sample NNS cord-005453-4057qib7 2421 9 collected collect VBN cord-005453-4057qib7 2421 10 , , , cord-005453-4057qib7 2421 11 reducing reduce VBG cord-005453-4057qib7 2421 12 nursing nursing NN cord-005453-4057qib7 2421 13 and and CC cord-005453-4057qib7 2421 14 laboratory laboratory NN cord-005453-4057qib7 2421 15 staff staff NN cord-005453-4057qib7 2421 16 time time NN cord-005453-4057qib7 2421 17 and and CC cord-005453-4057qib7 2421 18 increasing increase VBG cord-005453-4057qib7 2421 19 patient patient JJ cord-005453-4057qib7 2421 20 convenience convenience NN cord-005453-4057qib7 2421 21 . . . cord-005453-4057qib7 2422 1 This this DT cord-005453-4057qib7 2422 2 study study NN cord-005453-4057qib7 2422 3 aims aim VBZ cord-005453-4057qib7 2422 4 to to TO cord-005453-4057qib7 2422 5 show show VB cord-005453-4057qib7 2422 6 the the DT cord-005453-4057qib7 2422 7 performance performance NN cord-005453-4057qib7 2422 8 of of IN cord-005453-4057qib7 2422 9 a a DT cord-005453-4057qib7 2422 10 simplified simplified JJ cord-005453-4057qib7 2422 11 sampling sampling NN cord-005453-4057qib7 2422 12 protocol protocol NN cord-005453-4057qib7 2422 13 which which WDT cord-005453-4057qib7 2422 14 includes include VBZ cord-005453-4057qib7 2422 15 the the DT cord-005453-4057qib7 2422 16 first first JJ cord-005453-4057qib7 2422 17 5 5 CD cord-005453-4057qib7 2422 18 samples sample NNS cord-005453-4057qib7 2422 19 from from IN cord-005453-4057qib7 2422 20 the the DT cord-005453-4057qib7 2422 21 original original JJ cord-005453-4057qib7 2422 22 protocol protocol NN cord-005453-4057qib7 2422 23 . . . cord-005453-4057qib7 2423 1 Methods method NNS cord-005453-4057qib7 2423 2 : : : cord-005453-4057qib7 2424 1 Individual individual JJ cord-005453-4057qib7 2424 2 PK PK NNP cord-005453-4057qib7 2424 3 parameters parameter NNS cord-005453-4057qib7 2424 4 were be VBD cord-005453-4057qib7 2424 5 retrospectively retrospectively RB cord-005453-4057qib7 2424 6 estimated estimate VBN cord-005453-4057qib7 2424 7 using use VBG cord-005453-4057qib7 2424 8 5 5 CD cord-005453-4057qib7 2424 9 samples sample NNS cord-005453-4057qib7 2424 10 ( ( -LRB- cord-005453-4057qib7 2424 11 simplified simplified JJ cord-005453-4057qib7 2424 12 protocol protocol NN cord-005453-4057qib7 2424 13 ) ) -RRB- cord-005453-4057qib7 2424 14 and and CC cord-005453-4057qib7 2424 15 were be VBD cord-005453-4057qib7 2424 16 compared compare VBN cord-005453-4057qib7 2424 17 with with IN cord-005453-4057qib7 2424 18 those those DT cord-005453-4057qib7 2424 19 obtained obtain VBN cord-005453-4057qib7 2424 20 after after IN cord-005453-4057qib7 2424 21 8 8 CD cord-005453-4057qib7 2424 22 samples sample NNS cord-005453-4057qib7 2424 23 ( ( -LRB- cord-005453-4057qib7 2424 24 original original JJ cord-005453-4057qib7 2424 25 protocol protocol NN cord-005453-4057qib7 2424 26 ) ) -RRB- cord-005453-4057qib7 2424 27 . . . cord-005453-4057qib7 2425 1 Individual individual JJ cord-005453-4057qib7 2425 2 PK PK NNP cord-005453-4057qib7 2425 3 parameter parameter NN cord-005453-4057qib7 2425 4 values value NNS cord-005453-4057qib7 2425 5 for for IN cord-005453-4057qib7 2425 6 a a DT cord-005453-4057qib7 2425 7 one one CD cord-005453-4057qib7 2425 8 compartment compartment NN cord-005453-4057qib7 2425 9 model model NN cord-005453-4057qib7 2425 10 were be VBD cord-005453-4057qib7 2425 11 estimated estimate VBN cord-005453-4057qib7 2425 12 using use VBG cord-005453-4057qib7 2425 13 a a DT cord-005453-4057qib7 2425 14 maximum maximum JJ cord-005453-4057qib7 2425 15 likelihood likelihood NN cord-005453-4057qib7 2425 16 estimation estimation NN cord-005453-4057qib7 2425 17 modelling modelling NN cord-005453-4057qib7 2425 18 algorithm algorithm NN cord-005453-4057qib7 2425 19 ( ( -LRB- cord-005453-4057qib7 2425 20 ADAPT adapt VB cord-005453-4057qib7 2425 21 5.0 5.0 CD cord-005453-4057qib7 2425 22 ) ) -RRB- cord-005453-4057qib7 2425 23 and and CC cord-005453-4057qib7 2425 24 the the DT cord-005453-4057qib7 2425 25 statistical statistical JJ cord-005453-4057qib7 2425 26 analysis analysis NN cord-005453-4057qib7 2425 27 of of IN cord-005453-4057qib7 2425 28 the the DT cord-005453-4057qib7 2425 29 results result NNS cord-005453-4057qib7 2425 30 was be VBD cord-005453-4057qib7 2425 31 performed perform VBN cord-005453-4057qib7 2425 32 ( ( -LRB- cord-005453-4057qib7 2425 33 Statgraphics Statgraphics NNP cord-005453-4057qib7 2425 34 Centurion Centurion NNP cord-005453-4057qib7 2425 35 XV XV NNP cord-005453-4057qib7 2425 36 ) ) -RRB- cord-005453-4057qib7 2425 37 . . . cord-005453-4057qib7 2426 1 Results result NNS cord-005453-4057qib7 2426 2 Based base VBN cord-005453-4057qib7 2426 3 on on IN cord-005453-4057qib7 2426 4 the the DT cord-005453-4057qib7 2426 5 approved approve VBN cord-005453-4057qib7 2426 6 dosage dosage NN cord-005453-4057qib7 2426 7 recommendations recommendation NNS cord-005453-4057qib7 2426 8 , , , cord-005453-4057qib7 2426 9 mean mean JJ cord-005453-4057qib7 2426 10 ( ( -LRB- cord-005453-4057qib7 2426 11 SD sd NN cord-005453-4057qib7 2426 12 ) ) -RRB- cord-005453-4057qib7 2426 13 initial initial JJ cord-005453-4057qib7 2426 14 dose dose NN cord-005453-4057qib7 2426 15 was be VBD cord-005453-4057qib7 2426 16 171.1(69.3 171.1(69.3 CD cord-005453-4057qib7 2426 17 ) ) -RRB- cord-005453-4057qib7 2427 1 mg mg NNP cord-005453-4057qib7 2427 2 . . . cord-005453-4057qib7 2428 1 After after IN cord-005453-4057qib7 2428 2 TDM TDM NNP cord-005453-4057qib7 2428 3 , , , cord-005453-4057qib7 2428 4 mean mean JJ cord-005453-4057qib7 2428 5 ( ( -LRB- cord-005453-4057qib7 2428 6 SD sd NN cord-005453-4057qib7 2428 7 ) ) -RRB- cord-005453-4057qib7 2428 8 calculated calculate VBN cord-005453-4057qib7 2428 9 dose dose NN cord-005453-4057qib7 2428 10 at at IN cord-005453-4057qib7 2428 11 day day NN cord-005453-4057qib7 2428 12 1 1 CD cord-005453-4057qib7 2428 13 for for IN cord-005453-4057qib7 2428 14 the the DT cord-005453-4057qib7 2428 15 remaining remain VBG cord-005453-4057qib7 2428 16 days day NNS cord-005453-4057qib7 2428 17 ( ( -LRB- cord-005453-4057qib7 2428 18 to to TO cord-005453-4057qib7 2428 19 achieve achieve VB cord-005453-4057qib7 2428 20 the the DT cord-005453-4057qib7 2428 21 defined define VBN cord-005453-4057qib7 2428 22 target target NN cord-005453-4057qib7 2428 23 cumulative cumulative JJ cord-005453-4057qib7 2428 24 AUC AUC NNP cord-005453-4057qib7 2428 25 ) ) -RRB- cord-005453-4057qib7 2428 26 was be VBD cord-005453-4057qib7 2428 27 158,5 158,5 CD cord-005453-4057qib7 2429 1 ( ( -LRB- cord-005453-4057qib7 2429 2 72,6 72,6 LS cord-005453-4057qib7 2429 3 ) ) -RRB- cord-005453-4057qib7 2430 1 mg mg PRP cord-005453-4057qib7 2430 2 obtained obtain VBD cord-005453-4057qib7 2430 3 from from IN cord-005453-4057qib7 2430 4 the the DT cord-005453-4057qib7 2430 5 original original JJ cord-005453-4057qib7 2430 6 protocol protocol NN cord-005453-4057qib7 2430 7 . . . cord-005453-4057qib7 2431 1 According accord VBG cord-005453-4057qib7 2431 2 to to IN cord-005453-4057qib7 2431 3 the the DT cord-005453-4057qib7 2431 4 simplified simplified JJ cord-005453-4057qib7 2431 5 protocol protocol NN cord-005453-4057qib7 2431 6 the the DT cord-005453-4057qib7 2431 7 result result NN cord-005453-4057qib7 2431 8 would would MD cord-005453-4057qib7 2431 9 be be VB cord-005453-4057qib7 2431 10 159,8(73,7 159,8(73,7 CD cord-005453-4057qib7 2431 11 ) ) -RRB- cord-005453-4057qib7 2431 12 mg mg NN cord-005453-4057qib7 2431 13 . . . cord-005453-4057qib7 2432 1 The the DT cord-005453-4057qib7 2432 2 median median NN cord-005453-4057qib7 2432 3 and and CC cord-005453-4057qib7 2432 4 the the DT cord-005453-4057qib7 2432 5 mean mean JJ cord-005453-4057qib7 2432 6 variation variation NN cord-005453-4057qib7 2432 7 of of IN cord-005453-4057qib7 2432 8 the the DT cord-005453-4057qib7 2432 9 calculated calculated JJ cord-005453-4057qib7 2432 10 dose dose NN cord-005453-4057qib7 2432 11 were be VBD cord-005453-4057qib7 2432 12 0 0 CD cord-005453-4057qib7 2432 13 % % NN cord-005453-4057qib7 2432 14 and and CC cord-005453-4057qib7 2432 15 1 1 CD cord-005453-4057qib7 2432 16 % % NN cord-005453-4057qib7 2432 17 ( ( -LRB- cord-005453-4057qib7 2432 18 0 0 CD cord-005453-4057qib7 2432 19 - - SYM cord-005453-4057qib7 2432 20 8 8 CD cord-005453-4057qib7 2432 21 % % NN cord-005453-4057qib7 2432 22 ) ) -RRB- cord-005453-4057qib7 2432 23 between between IN cord-005453-4057qib7 2432 24 protocols protocol NNS cord-005453-4057qib7 2432 25 . . . cord-005453-4057qib7 2433 1 A a DT cord-005453-4057qib7 2433 2 strong strong JJ cord-005453-4057qib7 2433 3 relationship relationship NN cord-005453-4057qib7 2433 4 between between IN cord-005453-4057qib7 2433 5 the the DT cord-005453-4057qib7 2433 6 CL CL NNP cord-005453-4057qib7 2433 7 of of IN cord-005453-4057qib7 2433 8 the the DT cord-005453-4057qib7 2433 9 day day NN cord-005453-4057qib7 2433 10 1 1 CD cord-005453-4057qib7 2433 11 - - SYM cord-005453-4057qib7 2433 12 3 3 CD cord-005453-4057qib7 2433 13 obtained obtain VBD cord-005453-4057qib7 2433 14 from from IN cord-005453-4057qib7 2433 15 the the DT cord-005453-4057qib7 2433 16 original original JJ cord-005453-4057qib7 2433 17 protocol protocol NN cord-005453-4057qib7 2433 18 and and CC cord-005453-4057qib7 2433 19 the the DT cord-005453-4057qib7 2433 20 simplified simplified JJ cord-005453-4057qib7 2433 21 protocol protocol NN cord-005453-4057qib7 2433 22 is be VBZ cord-005453-4057qib7 2433 23 observed observe VBN cord-005453-4057qib7 2433 24 ( ( -LRB- cord-005453-4057qib7 2433 25 R r NN cord-005453-4057qib7 2433 26 2 2 CD cord-005453-4057qib7 2433 27 = = SYM cord-005453-4057qib7 2433 28 0.9985 0.9985 CD cord-005453-4057qib7 2433 29 ) ) -RRB- cord-005453-4057qib7 2433 30 . . . cord-005453-4057qib7 2434 1 This this DT cord-005453-4057qib7 2434 2 high high JJ cord-005453-4057qib7 2434 3 correlation correlation NN cord-005453-4057qib7 2434 4 is be VBZ cord-005453-4057qib7 2434 5 also also RB cord-005453-4057qib7 2434 6 observed observe VBN cord-005453-4057qib7 2434 7 for for IN cord-005453-4057qib7 2434 8 patients patient NNS cord-005453-4057qib7 2434 9 with with IN cord-005453-4057qib7 2434 10 busulfan busulfan NNP cord-005453-4057qib7 2434 11 t t NNP cord-005453-4057qib7 2434 12 1/2 1/2 CD cord-005453-4057qib7 2435 1 > > XX cord-005453-4057qib7 2436 1 3h 3h NNP cord-005453-4057qib7 2436 2 ( ( -LRB- cord-005453-4057qib7 2436 3 R r NN cord-005453-4057qib7 2436 4 2 2 CD cord-005453-4057qib7 2436 5 = = SYM cord-005453-4057qib7 2436 6 0.9936 0.9936 CD cord-005453-4057qib7 2436 7 ) ) -RRB- cord-005453-4057qib7 2437 1 , , , cord-005453-4057qib7 2437 2 a a DT cord-005453-4057qib7 2437 3 population population NN cord-005453-4057qib7 2437 4 were be VBD cord-005453-4057qib7 2437 5 the the DT cord-005453-4057qib7 2437 6 reduction reduction NN cord-005453-4057qib7 2437 7 of of IN cord-005453-4057qib7 2437 8 sampling sampling NN cord-005453-4057qib7 2437 9 could could MD cord-005453-4057qib7 2437 10 be be VB cord-005453-4057qib7 2437 11 more more RBR cord-005453-4057qib7 2437 12 problematic problematic JJ cord-005453-4057qib7 2437 13 . . . cord-005453-4057qib7 2438 1 ANOVA ANOVA NNP cord-005453-4057qib7 2438 2 test test NN cord-005453-4057qib7 2438 3 for for IN cord-005453-4057qib7 2438 4 the the DT cord-005453-4057qib7 2438 5 log log NN cord-005453-4057qib7 2438 6 CL CL NNP cord-005453-4057qib7 2438 7 with with IN cord-005453-4057qib7 2438 8 the the DT cord-005453-4057qib7 2438 9 factors factor NNS cord-005453-4057qib7 2438 10 : : : cord-005453-4057qib7 2438 11 patient patient JJ cord-005453-4057qib7 2438 12 , , , cord-005453-4057qib7 2438 13 day day NN cord-005453-4057qib7 2438 14 of of IN cord-005453-4057qib7 2438 15 busulfan busulfan NN cord-005453-4057qib7 2438 16 and and CC cord-005453-4057qib7 2438 17 type type NN cord-005453-4057qib7 2438 18 of of IN cord-005453-4057qib7 2438 19 sampling sampling NN cord-005453-4057qib7 2438 20 protocol protocol NN cord-005453-4057qib7 2438 21 was be VBD cord-005453-4057qib7 2438 22 performed perform VBN cord-005453-4057qib7 2438 23 . . . cord-005453-4057qib7 2439 1 Sampling sampling NN cord-005453-4057qib7 2439 2 protocol protocol NN cord-005453-4057qib7 2439 3 was be VBD cord-005453-4057qib7 2439 4 determined determine VBN cord-005453-4057qib7 2439 5 as as IN cord-005453-4057qib7 2439 6 non non JJ cord-005453-4057qib7 2439 7 - - JJ cord-005453-4057qib7 2439 8 statistically statistically RB cord-005453-4057qib7 2439 9 significant significant JJ cord-005453-4057qib7 2439 10 ( ( -LRB- cord-005453-4057qib7 2439 11 p p NN cord-005453-4057qib7 2439 12 = = SYM cord-005453-4057qib7 2439 13 0.7248 0.7248 CD cord-005453-4057qib7 2439 14 ) ) -RRB- cord-005453-4057qib7 2439 15 . . . cord-005453-4057qib7 2440 1 Conclusions conclusion NNS cord-005453-4057qib7 2440 2 : : : cord-005453-4057qib7 2441 1 Results result NNS cord-005453-4057qib7 2441 2 suggest suggest VBP cord-005453-4057qib7 2441 3 that that IN cord-005453-4057qib7 2441 4 both both DT cord-005453-4057qib7 2441 5 protocols protocol NNS cord-005453-4057qib7 2441 6 are be VBP cord-005453-4057qib7 2441 7 equivalent equivalent JJ cord-005453-4057qib7 2441 8 concerning concern VBG cord-005453-4057qib7 2441 9 to to IN cord-005453-4057qib7 2441 10 the the DT cord-005453-4057qib7 2441 11 busulfan busulfan NN cord-005453-4057qib7 2441 12 CL CL NNP cord-005453-4057qib7 2441 13 estimation estimation NN cord-005453-4057qib7 2441 14 and and CC cord-005453-4057qib7 2441 15 calculated calculate VBD cord-005453-4057qib7 2441 16 AUC AUC NNP cord-005453-4057qib7 2441 17 . . . cord-005453-4057qib7 2442 1 Variation variation NN cord-005453-4057qib7 2442 2 between between IN cord-005453-4057qib7 2442 3 protocols protocol NNS cord-005453-4057qib7 2442 4 regarding regard VBG cord-005453-4057qib7 2442 5 the the DT cord-005453-4057qib7 2442 6 calculated calculated JJ cord-005453-4057qib7 2442 7 dose dose NN cord-005453-4057qib7 2442 8 at at IN cord-005453-4057qib7 2442 9 day day NN cord-005453-4057qib7 2442 10 1 1 CD cord-005453-4057qib7 2442 11 for for IN cord-005453-4057qib7 2442 12 the the DT cord-005453-4057qib7 2442 13 remaining remain VBG cord-005453-4057qib7 2442 14 days day NNS cord-005453-4057qib7 2442 15 to to TO cord-005453-4057qib7 2442 16 achieve achieve VB cord-005453-4057qib7 2442 17 the the DT cord-005453-4057qib7 2442 18 defined define VBN cord-005453-4057qib7 2442 19 target target NN cord-005453-4057qib7 2442 20 cumulative cumulative JJ cord-005453-4057qib7 2442 21 AUC AUC NNP cord-005453-4057qib7 2442 22 is be VBZ cord-005453-4057qib7 2442 23 considered consider VBN cord-005453-4057qib7 2442 24 acceptable acceptable JJ cord-005453-4057qib7 2442 25 . . . cord-005453-4057qib7 2443 1 We -PRON- PRP cord-005453-4057qib7 2443 2 verified verify VBD cord-005453-4057qib7 2443 3 a a DT cord-005453-4057qib7 2443 4 strong strong JJ cord-005453-4057qib7 2443 5 relationship relationship NN cord-005453-4057qib7 2443 6 between between IN cord-005453-4057qib7 2443 7 busulfan busulfan NN cord-005453-4057qib7 2443 8 CL CL NNP cord-005453-4057qib7 2443 9 obtained obtain VBD cord-005453-4057qib7 2443 10 from from IN cord-005453-4057qib7 2443 11 both both DT cord-005453-4057qib7 2443 12 protocols protocol NNS cord-005453-4057qib7 2443 13 and and CC cord-005453-4057qib7 2443 14 sampling sampling NN cord-005453-4057qib7 2443 15 protocol protocol NN cord-005453-4057qib7 2443 16 does do VBZ cord-005453-4057qib7 2443 17 n't not RB cord-005453-4057qib7 2443 18 influence influence VB cord-005453-4057qib7 2443 19 CL CL NNP cord-005453-4057qib7 2443 20 statistically statistically RB cord-005453-4057qib7 2443 21 . . . cord-005453-4057qib7 2444 1 A a DT cord-005453-4057qib7 2444 2 reduced reduce VBN cord-005453-4057qib7 2444 3 sampling sampling NN cord-005453-4057qib7 2444 4 collection collection NN cord-005453-4057qib7 2444 5 of of IN cord-005453-4057qib7 2444 6 5 5 CD cord-005453-4057qib7 2444 7 determinations determination NNS cord-005453-4057qib7 2444 8 until until IN cord-005453-4057qib7 2444 9 4 4 CD cord-005453-4057qib7 2444 10 h h NN cord-005453-4057qib7 2444 11 after after IN cord-005453-4057qib7 2444 12 the the DT cord-005453-4057qib7 2444 13 end end NN cord-005453-4057qib7 2444 14 of of IN cord-005453-4057qib7 2444 15 the the DT cord-005453-4057qib7 2444 16 infusion infusion NN cord-005453-4057qib7 2444 17 is be VBZ cord-005453-4057qib7 2444 18 shown show VBN cord-005453-4057qib7 2444 19 to to TO cord-005453-4057qib7 2444 20 be be VB cord-005453-4057qib7 2444 21 sufficient sufficient JJ cord-005453-4057qib7 2444 22 for for IN cord-005453-4057qib7 2444 23 the the DT cord-005453-4057qib7 2444 24 TDM tdm NN cord-005453-4057qib7 2444 25 of of IN cord-005453-4057qib7 2444 26 busulfan busulfan NN cord-005453-4057qib7 2444 27 , , , cord-005453-4057qib7 2444 28 so so CC cord-005453-4057qib7 2444 29 this this DT cord-005453-4057qib7 2444 30 was be VBD cord-005453-4057qib7 2444 31 implemented implement VBN cord-005453-4057qib7 2444 32 in in IN cord-005453-4057qib7 2444 33 our -PRON- PRP$ cord-005453-4057qib7 2444 34 centre centre NN cord-005453-4057qib7 2444 35 in in IN cord-005453-4057qib7 2444 36 line line NN cord-005453-4057qib7 2444 37 with with IN cord-005453-4057qib7 2444 38 published publish VBN cord-005453-4057qib7 2444 39 data datum NNS cord-005453-4057qib7 2444 40 . . . cord-005453-4057qib7 2445 1 Disclosure disclosure NN cord-005453-4057qib7 2445 2 : : : cord-005453-4057qib7 2445 3 Nothing nothing NN cord-005453-4057qib7 2445 4 to to TO cord-005453-4057qib7 2445 5 declare declare VB cord-005453-4057qib7 2445 6 P125 P125 NNP cord-005453-4057qib7 2445 7 Impact Impact NNP cord-005453-4057qib7 2445 8 of of IN cord-005453-4057qib7 2445 9 anti anti JJ cord-005453-4057qib7 2445 10 - - JJ cord-005453-4057qib7 2445 11 thymocyte thymocyte JJ cord-005453-4057qib7 2445 12 globulin globulin NN cord-005453-4057qib7 2445 13 doses dose NNS cord-005453-4057qib7 2445 14 in in IN cord-005453-4057qib7 2445 15 unrelated unrelated JJ cord-005453-4057qib7 2445 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 2445 17 stem stem NN cord-005453-4057qib7 2445 18 cell cell NN cord-005453-4057qib7 2445 19 transplantation transplantation NN cord-005453-4057qib7 2445 20 for for IN cord-005453-4057qib7 2445 21 patients patient NNS cord-005453-4057qib7 2445 22 with with IN cord-005453-4057qib7 2445 23 myeloid myeloid NN cord-005453-4057qib7 2445 24 neoplasm neoplasm NN cord-005453-4057qib7 2445 25 Background background NN cord-005453-4057qib7 2445 26 : : : cord-005453-4057qib7 2445 27 Anti anti JJ cord-005453-4057qib7 2445 28 - - JJ cord-005453-4057qib7 2445 29 thymocyte thymocyte JJ cord-005453-4057qib7 2445 30 globulin globulin NN cord-005453-4057qib7 2445 31 ( ( -LRB- cord-005453-4057qib7 2445 32 ATG ATG NNP cord-005453-4057qib7 2445 33 ) ) -RRB- cord-005453-4057qib7 2445 34 is be VBZ cord-005453-4057qib7 2445 35 widely widely RB cord-005453-4057qib7 2445 36 used use VBN cord-005453-4057qib7 2445 37 for for IN cord-005453-4057qib7 2445 38 the the DT cord-005453-4057qib7 2445 39 prophylaxis prophylaxis NN cord-005453-4057qib7 2445 40 of of IN cord-005453-4057qib7 2445 41 graft graft NN cord-005453-4057qib7 2445 42 - - HYPH cord-005453-4057qib7 2445 43 versus versus IN cord-005453-4057qib7 2445 44 - - HYPH cord-005453-4057qib7 2445 45 host host NN cord-005453-4057qib7 2445 46 disease disease NN cord-005453-4057qib7 2445 47 ( ( -LRB- cord-005453-4057qib7 2445 48 GVHD GVHD NNP cord-005453-4057qib7 2445 49 ) ) -RRB- cord-005453-4057qib7 2445 50 in in IN cord-005453-4057qib7 2445 51 hematopoietic hematopoietic JJ cord-005453-4057qib7 2445 52 stem stem NN cord-005453-4057qib7 2445 53 cell cell NN cord-005453-4057qib7 2445 54 transplantation transplantation NN cord-005453-4057qib7 2445 55 ( ( -LRB- cord-005453-4057qib7 2445 56 HSCT HSCT NNP cord-005453-4057qib7 2445 57 ) ) -RRB- cord-005453-4057qib7 2445 58 . . . cord-005453-4057qib7 2446 1 However however RB cord-005453-4057qib7 2446 2 , , , cord-005453-4057qib7 2446 3 there there EX cord-005453-4057qib7 2446 4 is be VBZ cord-005453-4057qib7 2446 5 still still RB cord-005453-4057qib7 2446 6 controversy controversy NN cord-005453-4057qib7 2446 7 regarding regard VBG cord-005453-4057qib7 2446 8 the the DT cord-005453-4057qib7 2446 9 optimal optimal JJ cord-005453-4057qib7 2446 10 dose dose NN cord-005453-4057qib7 2446 11 of of IN cord-005453-4057qib7 2446 12 ATG ATG NNP cord-005453-4057qib7 2446 13 . . . cord-005453-4057qib7 2447 1 Therefore therefore RB cord-005453-4057qib7 2447 2 , , , cord-005453-4057qib7 2447 3 we -PRON- PRP cord-005453-4057qib7 2447 4 analyzed analyze VBD cord-005453-4057qib7 2447 5 the the DT cord-005453-4057qib7 2447 6 impact impact NN cord-005453-4057qib7 2447 7 of of IN cord-005453-4057qib7 2447 8 ATG ATG NNP cord-005453-4057qib7 2447 9 doses dose NNS cord-005453-4057qib7 2447 10 in in IN cord-005453-4057qib7 2447 11 unrelated unrelated JJ cord-005453-4057qib7 2447 12 HSCT HSCT NNP cord-005453-4057qib7 2447 13 for for IN cord-005453-4057qib7 2447 14 patients patient NNS cord-005453-4057qib7 2447 15 with with IN cord-005453-4057qib7 2447 16 myeloid myeloid JJ cord-005453-4057qib7 2447 17 neoplasm neoplasm NN cord-005453-4057qib7 2447 18 . . . cord-005453-4057qib7 2448 1 Methods method NNS cord-005453-4057qib7 2448 2 : : : cord-005453-4057qib7 2448 3 This this DT cord-005453-4057qib7 2448 4 was be VBD cord-005453-4057qib7 2448 5 a a DT cord-005453-4057qib7 2448 6 retrospective retrospective JJ cord-005453-4057qib7 2448 7 multi multi JJ cord-005453-4057qib7 2448 8 - - JJ cord-005453-4057qib7 2448 9 center center JJ cord-005453-4057qib7 2448 10 study study NN cord-005453-4057qib7 2448 11 that that WDT cord-005453-4057qib7 2448 12 assessed assess VBD cord-005453-4057qib7 2448 13 the the DT cord-005453-4057qib7 2448 14 impact impact NN cord-005453-4057qib7 2448 15 of of IN cord-005453-4057qib7 2448 16 ATG ATG NNP cord-005453-4057qib7 2448 17 doses dose NNS cord-005453-4057qib7 2448 18 on on IN cord-005453-4057qib7 2448 19 clinical clinical JJ cord-005453-4057qib7 2448 20 outcomes outcome NNS cord-005453-4057qib7 2448 21 in in IN cord-005453-4057qib7 2448 22 patients patient NNS cord-005453-4057qib7 2448 23 with with IN cord-005453-4057qib7 2448 24 acute acute JJ cord-005453-4057qib7 2448 25 myeloid myeloid NN cord-005453-4057qib7 2448 26 leukemia leukemia NN cord-005453-4057qib7 2448 27 ( ( -LRB- cord-005453-4057qib7 2448 28 AML AML NNP cord-005453-4057qib7 2448 29 ) ) -RRB- cord-005453-4057qib7 2448 30 or or CC cord-005453-4057qib7 2448 31 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 2448 32 syndrome syndrome NN cord-005453-4057qib7 2448 33 ( ( -LRB- cord-005453-4057qib7 2448 34 MDS MDS NNP cord-005453-4057qib7 2448 35 ) ) -RRB- cord-005453-4057qib7 2448 36 undergoing undergo VBG cord-005453-4057qib7 2448 37 an an DT cord-005453-4057qib7 2448 38 unrelated unrelated JJ cord-005453-4057qib7 2448 39 HSCT HSCT NNP cord-005453-4057qib7 2448 40 . . . cord-005453-4057qib7 2449 1 The the DT cord-005453-4057qib7 2449 2 patients patient NNS cord-005453-4057qib7 2449 3 who who WP cord-005453-4057qib7 2449 4 received receive VBD cord-005453-4057qib7 2449 5 peripheral peripheral JJ cord-005453-4057qib7 2449 6 blood blood NN cord-005453-4057qib7 2449 7 stem stem NN cord-005453-4057qib7 2449 8 cells cell NNS cord-005453-4057qib7 2449 9 ( ( -LRB- cord-005453-4057qib7 2449 10 PBSC PBSC NNP cord-005453-4057qib7 2449 11 ) ) -RRB- cord-005453-4057qib7 2449 12 transplantation transplantation NN cord-005453-4057qib7 2449 13 after after IN cord-005453-4057qib7 2449 14 conditioning conditioning NN cord-005453-4057qib7 2449 15 regimens regimen NNS cord-005453-4057qib7 2449 16 containing contain VBG cord-005453-4057qib7 2449 17 i.v i.v NNP cord-005453-4057qib7 2449 18 . . . cord-005453-4057qib7 2449 19 busulfan busulfan NNP cord-005453-4057qib7 2449 20 ( ( -LRB- cord-005453-4057qib7 2449 21 BU BU NNP cord-005453-4057qib7 2449 22 ) ) -RRB- cord-005453-4057qib7 2449 23 , , , cord-005453-4057qib7 2449 24 fludarabine fludarabine NN cord-005453-4057qib7 2449 25 and and CC cord-005453-4057qib7 2449 26 rabbit rabbit NN cord-005453-4057qib7 2449 27 ATG ATG NNP cord-005453-4057qib7 2449 28 between between IN cord-005453-4057qib7 2449 29 2010 2010 CD cord-005453-4057qib7 2449 30 and and CC cord-005453-4057qib7 2449 31 2017 2017 CD cord-005453-4057qib7 2449 32 were be VBD cord-005453-4057qib7 2449 33 included include VBN cord-005453-4057qib7 2449 34 in in IN cord-005453-4057qib7 2449 35 this this DT cord-005453-4057qib7 2449 36 study study NN cord-005453-4057qib7 2449 37 . . . cord-005453-4057qib7 2450 1 Results result NNS cord-005453-4057qib7 2450 2 : : : cord-005453-4057qib7 2451 1 A a DT cord-005453-4057qib7 2451 2 total total NN cord-005453-4057qib7 2451 3 of of IN cord-005453-4057qib7 2451 4 96 96 CD cord-005453-4057qib7 2451 5 patents patent NNS cord-005453-4057qib7 2451 6 , , , cord-005453-4057qib7 2451 7 median median JJ cord-005453-4057qib7 2451 8 age age NN cord-005453-4057qib7 2451 9 45 45 CD cord-005453-4057qib7 2451 10 years year NNS cord-005453-4057qib7 2451 11 , , , cord-005453-4057qib7 2451 12 with with IN cord-005453-4057qib7 2451 13 AML AML NNP cord-005453-4057qib7 2451 14 ( ( -LRB- cord-005453-4057qib7 2451 15 n=74 n=74 NNP cord-005453-4057qib7 2451 16 ) ) -RRB- cord-005453-4057qib7 2451 17 or or CC cord-005453-4057qib7 2451 18 MDS MDS NNP cord-005453-4057qib7 2451 19 ( ( -LRB- cord-005453-4057qib7 2451 20 n=22 n=22 NNP cord-005453-4057qib7 2451 21 ) ) -RRB- cord-005453-4057qib7 2451 22 were be VBD cord-005453-4057qib7 2451 23 included include VBN cord-005453-4057qib7 2451 24 in in IN cord-005453-4057qib7 2451 25 our -PRON- PRP$ cord-005453-4057qib7 2451 26 analyses analysis NNS cord-005453-4057qib7 2451 27 . . . cord-005453-4057qib7 2452 1 66 66 CD cord-005453-4057qib7 2452 2 patients patient NNS cord-005453-4057qib7 2452 3 ( ( -LRB- cord-005453-4057qib7 2452 4 69 69 CD cord-005453-4057qib7 2452 5 % % NN cord-005453-4057qib7 2452 6 ) ) -RRB- cord-005453-4057qib7 2452 7 received receive VBD cord-005453-4057qib7 2452 8 a a DT cord-005453-4057qib7 2452 9 myeloablative myeloablative JJ cord-005453-4057qib7 2452 10 regimen regimen NN cord-005453-4057qib7 2452 11 ( ( -LRB- cord-005453-4057qib7 2452 12 i.v i.v NNP cord-005453-4057qib7 2452 13 . . . cord-005453-4057qib7 2452 14 BU>6.4 BU>6.4 NNP cord-005453-4057qib7 2452 15 mg mg NNP cord-005453-4057qib7 2452 16 / / SYM cord-005453-4057qib7 2452 17 kg kg NNP cord-005453-4057qib7 2452 18 ) ) -RRB- cord-005453-4057qib7 2452 19 . . . cord-005453-4057qib7 2453 1 High High NNP cord-005453-4057qib7 2453 2 - - HYPH cord-005453-4057qib7 2453 3 ATG ATG NNP cord-005453-4057qib7 2453 4 ( ( -LRB- cord-005453-4057qib7 2453 5 ATG ATG NNP cord-005453-4057qib7 2453 6 9 9 CD cord-005453-4057qib7 2453 7 mg mg NNP cord-005453-4057qib7 2453 8 / / SYM cord-005453-4057qib7 2453 9 kg kg NNP cord-005453-4057qib7 2453 10 ) ) -RRB- cord-005453-4057qib7 2453 11 , , , cord-005453-4057qib7 2453 12 intermediate intermediate JJ cord-005453-4057qib7 2453 13 - - HYPH cord-005453-4057qib7 2453 14 ATG ATG NNP cord-005453-4057qib7 2453 15 ( ( -LRB- cord-005453-4057qib7 2453 16 ATG ATG NNP cord-005453-4057qib7 2453 17 4.5 4.5 CD cord-005453-4057qib7 2453 18 - - SYM cord-005453-4057qib7 2453 19 5 5 CD cord-005453-4057qib7 2453 20 mg mg NNP cord-005453-4057qib7 2453 21 / / SYM cord-005453-4057qib7 2453 22 kg kg NNP cord-005453-4057qib7 2453 23 ) ) -RRB- cord-005453-4057qib7 2453 24 and and CC cord-005453-4057qib7 2453 25 low low JJ cord-005453-4057qib7 2453 26 - - HYPH cord-005453-4057qib7 2453 27 ATG ATG NNP cord-005453-4057qib7 2453 28 ( ( -LRB- cord-005453-4057qib7 2453 29 ATG ATG NNP cord-005453-4057qib7 2453 30 3 3 CD cord-005453-4057qib7 2453 31 mg mg NNP cord-005453-4057qib7 2453 32 / / SYM cord-005453-4057qib7 2453 33 kg kg NNP cord-005453-4057qib7 2453 34 ) ) -RRB- cord-005453-4057qib7 2453 35 were be VBD cord-005453-4057qib7 2453 36 given give VBN cord-005453-4057qib7 2453 37 in in IN cord-005453-4057qib7 2453 38 11 11 CD cord-005453-4057qib7 2453 39 , , , cord-005453-4057qib7 2453 40 49 49 CD cord-005453-4057qib7 2453 41 and and CC cord-005453-4057qib7 2453 42 36 36 CD cord-005453-4057qib7 2453 43 patients patient NNS cord-005453-4057qib7 2453 44 , , , cord-005453-4057qib7 2453 45 respectively respectively RB cord-005453-4057qib7 2453 46 . . . cord-005453-4057qib7 2454 1 After after IN cord-005453-4057qib7 2454 2 a a DT cord-005453-4057qib7 2454 3 median median JJ cord-005453-4057qib7 2454 4 follow follow NN cord-005453-4057qib7 2454 5 - - HYPH cord-005453-4057qib7 2454 6 up up NN cord-005453-4057qib7 2454 7 of of IN cord-005453-4057qib7 2454 8 23 23 CD cord-005453-4057qib7 2454 9 months month NNS cord-005453-4057qib7 2454 10 , , , cord-005453-4057qib7 2454 11 the the DT cord-005453-4057qib7 2454 12 cumulative cumulative JJ cord-005453-4057qib7 2454 13 incidence incidence NN cord-005453-4057qib7 2454 14 of of IN cord-005453-4057qib7 2454 15 extensive extensive JJ cord-005453-4057qib7 2454 16 chronic chronic JJ cord-005453-4057qib7 2454 17 GVHD GVHD NNP cord-005453-4057qib7 2454 18 was be VBD cord-005453-4057qib7 2454 19 9.1 9.1 CD cord-005453-4057qib7 2454 20 % % NN cord-005453-4057qib7 2454 21 in in IN cord-005453-4057qib7 2454 22 the the DT cord-005453-4057qib7 2454 23 high high JJ cord-005453-4057qib7 2454 24 - - HYPH cord-005453-4057qib7 2454 25 ATG ATG NNP cord-005453-4057qib7 2454 26 group group NN cord-005453-4057qib7 2454 27 , , , cord-005453-4057qib7 2454 28 13.8 13.8 CD cord-005453-4057qib7 2454 29 % % NN cord-005453-4057qib7 2454 30 in in IN cord-005453-4057qib7 2454 31 the the DT cord-005453-4057qib7 2454 32 intermediate intermediate JJ cord-005453-4057qib7 2454 33 - - HYPH cord-005453-4057qib7 2454 34 ATG ATG NNP cord-005453-4057qib7 2454 35 group group NN cord-005453-4057qib7 2454 36 and and CC cord-005453-4057qib7 2454 37 29.7 29.7 CD cord-005453-4057qib7 2454 38 % % NN cord-005453-4057qib7 2454 39 in in IN cord-005453-4057qib7 2454 40 the the DT cord-005453-4057qib7 2454 41 low low JJ cord-005453-4057qib7 2454 42 - - HYPH cord-005453-4057qib7 2454 43 ATG atg NN cord-005453-4057qib7 2454 44 group group NN cord-005453-4057qib7 2454 45 ( ( -LRB- cord-005453-4057qib7 2454 46 p=0.31 p=0.31 NNP cord-005453-4057qib7 2454 47 ) ) -RRB- cord-005453-4057qib7 2454 48 . . . cord-005453-4057qib7 2455 1 Conclusions conclusion NNS cord-005453-4057qib7 2455 2 : : : cord-005453-4057qib7 2456 1 Our -PRON- PRP$ cord-005453-4057qib7 2456 2 study study NN cord-005453-4057qib7 2456 3 shows show VBZ cord-005453-4057qib7 2456 4 that that IN cord-005453-4057qib7 2456 5 the the DT cord-005453-4057qib7 2456 6 incidence incidence NN cord-005453-4057qib7 2456 7 of of IN cord-005453-4057qib7 2456 8 extensive extensive JJ cord-005453-4057qib7 2456 9 chronic chronic JJ cord-005453-4057qib7 2456 10 GVHD GVHD NNP cord-005453-4057qib7 2456 11 was be VBD cord-005453-4057qib7 2456 12 similar similar JJ cord-005453-4057qib7 2456 13 regardless regardless RB cord-005453-4057qib7 2456 14 of of IN cord-005453-4057qib7 2456 15 the the DT cord-005453-4057qib7 2456 16 doses dose NNS cord-005453-4057qib7 2456 17 of of IN cord-005453-4057qib7 2456 18 ATG ATG NNP cord-005453-4057qib7 2456 19 after after IN cord-005453-4057qib7 2456 20 transplantation transplantation NN cord-005453-4057qib7 2456 21 of of IN cord-005453-4057qib7 2456 22 PBSC PBSC NNP cord-005453-4057qib7 2456 23 from from IN cord-005453-4057qib7 2456 24 unrelated unrelated JJ cord-005453-4057qib7 2456 25 donor donor NN cord-005453-4057qib7 2456 26 for for IN cord-005453-4057qib7 2456 27 patients patient NNS cord-005453-4057qib7 2456 28 with with IN cord-005453-4057qib7 2456 29 AML AML NNP cord-005453-4057qib7 2456 30 or or CC cord-005453-4057qib7 2456 31 MDS MDS NNP cord-005453-4057qib7 2456 32 . . . cord-005453-4057qib7 2457 1 However however RB cord-005453-4057qib7 2457 2 , , , cord-005453-4057qib7 2457 3 the the DT cord-005453-4057qib7 2457 4 rate rate NN cord-005453-4057qib7 2457 5 of of IN cord-005453-4057qib7 2457 6 relapsefree relapsefree NNP cord-005453-4057qib7 2457 7 survival survival NN cord-005453-4057qib7 2457 8 and and CC cord-005453-4057qib7 2457 9 the the DT cord-005453-4057qib7 2457 10 rate rate NN cord-005453-4057qib7 2457 11 of of IN cord-005453-4057qib7 2457 12 a a DT cord-005453-4057qib7 2457 13 composite composite JJ cord-005453-4057qib7 2457 14 end end NN cord-005453-4057qib7 2457 15 point point NN cord-005453-4057qib7 2457 16 chronic chronic JJ cord-005453-4057qib7 2457 17 GVHD GVHD NNP cord-005453-4057qib7 2457 18 - - HYPH cord-005453-4057qib7 2457 19 free free JJ cord-005453-4057qib7 2457 20 and and CC cord-005453-4057qib7 2457 21 relapse relapse NN cord-005453-4057qib7 2457 22 - - HYPH cord-005453-4057qib7 2457 23 free free JJ cord-005453-4057qib7 2457 24 survival survival NN cord-005453-4057qib7 2457 25 were be VBD cord-005453-4057qib7 2457 26 significantly significantly RB cord-005453-4057qib7 2457 27 higher high JJR cord-005453-4057qib7 2457 28 in in IN cord-005453-4057qib7 2457 29 the the DT cord-005453-4057qib7 2457 30 intermediate intermediate JJ cord-005453-4057qib7 2457 31 dose dose NN cord-005453-4057qib7 2457 32 ( ( -LRB- cord-005453-4057qib7 2457 33 Methods method NNS cord-005453-4057qib7 2457 34 : : : cord-005453-4057qib7 2458 1 We -PRON- PRP cord-005453-4057qib7 2458 2 retrospectively retrospectively RB cord-005453-4057qib7 2458 3 retrieved retrieve VBD cord-005453-4057qib7 2458 4 data datum NNS cord-005453-4057qib7 2458 5 from from IN cord-005453-4057qib7 2458 6 the the DT cord-005453-4057qib7 2458 7 electronic electronic JJ cord-005453-4057qib7 2458 8 medical medical JJ cord-005453-4057qib7 2458 9 records record NNS cord-005453-4057qib7 2458 10 for for IN cord-005453-4057qib7 2458 11 consecutive consecutive JJ cord-005453-4057qib7 2458 12 patients patient NNS cord-005453-4057qib7 2458 13 aged age VBN cord-005453-4057qib7 2458 14 65 65 CD cord-005453-4057qib7 2458 15 and and CC cord-005453-4057qib7 2458 16 older old JJR cord-005453-4057qib7 2458 17 , , , cord-005453-4057qib7 2458 18 who who WP cord-005453-4057qib7 2458 19 underwent undergo VBD cord-005453-4057qib7 2458 20 an an DT cord-005453-4057qib7 2458 21 ASCT ASCT NNP cord-005453-4057qib7 2458 22 for for IN cord-005453-4057qib7 2458 23 lymphoma lymphoma NN cord-005453-4057qib7 2458 24 over over IN cord-005453-4057qib7 2458 25 the the DT cord-005453-4057qib7 2458 26 last last JJ cord-005453-4057qib7 2458 27 10 10 CD cord-005453-4057qib7 2458 28 years year NNS cord-005453-4057qib7 2458 29 at at IN cord-005453-4057qib7 2458 30 our -PRON- PRP$ cord-005453-4057qib7 2458 31 institution institution NN cord-005453-4057qib7 2458 32 . . . cord-005453-4057qib7 2459 1 Results result NNS cord-005453-4057qib7 2459 2 : : : cord-005453-4057qib7 2460 1 Forty forty CD cord-005453-4057qib7 2460 2 four four CD cord-005453-4057qib7 2460 3 patients patient NNS cord-005453-4057qib7 2460 4 ≥ ≥ CD cord-005453-4057qib7 2460 5 65 65 CD cord-005453-4057qib7 2460 6 years year NNS cord-005453-4057qib7 2460 7 old old JJ cord-005453-4057qib7 2460 8 underwent undergo VBD cord-005453-4057qib7 2460 9 ASCT ASCT NNP cord-005453-4057qib7 2460 10 between between IN cord-005453-4057qib7 2460 11 1 1 CD cord-005453-4057qib7 2460 12 Aug Aug NNP cord-005453-4057qib7 2460 13 2008 2008 CD cord-005453-4057qib7 2460 14 and and CC cord-005453-4057qib7 2460 15 31 31 CD cord-005453-4057qib7 2460 16 Aug Aug NNP cord-005453-4057qib7 2460 17 2018 2018 CD cord-005453-4057qib7 2460 18 . . . cord-005453-4057qib7 2461 1 Twenty twenty CD cord-005453-4057qib7 2461 2 eight eight CD cord-005453-4057qib7 2461 3 of of IN cord-005453-4057qib7 2461 4 them -PRON- PRP cord-005453-4057qib7 2461 5 received receive VBD cord-005453-4057qib7 2461 6 a a DT cord-005453-4057qib7 2461 7 reduced reduce VBN cord-005453-4057qib7 2461 8 - - HYPH cord-005453-4057qib7 2461 9 dose dose NN cord-005453-4057qib7 2461 10 conditioning conditioning NN cord-005453-4057qib7 2461 11 ( ( -LRB- cord-005453-4057qib7 2461 12 median median NN cord-005453-4057qib7 2461 13 25 25 CD cord-005453-4057qib7 2461 14 % % NN cord-005453-4057qib7 2461 15 , , , cord-005453-4057qib7 2461 16 range range VBP cord-005453-4057qib7 2461 17 20%-33 20%-33 CD cord-005453-4057qib7 2461 18 % % NN cord-005453-4057qib7 2461 19 dose dose NN cord-005453-4057qib7 2461 20 reduction reduction NN cord-005453-4057qib7 2461 21 ) ) -RRB- cord-005453-4057qib7 2461 22 . . . cord-005453-4057qib7 2462 1 The the DT cord-005453-4057qib7 2462 2 dose dose NN cord-005453-4057qib7 2462 3 was be VBD cord-005453-4057qib7 2462 4 reduced reduce VBN cord-005453-4057qib7 2462 5 for for IN cord-005453-4057qib7 2462 6 92 92 CD cord-005453-4057qib7 2462 7 % % NN cord-005453-4057qib7 2462 8 of of IN cord-005453-4057qib7 2462 9 patients patient NNS cord-005453-4057qib7 2462 10 ≥ ≥ CD cord-005453-4057qib7 2462 11 70 70 CD cord-005453-4057qib7 2462 12 years year NNS cord-005453-4057qib7 2462 13 old old JJ cord-005453-4057qib7 2462 14 and and CC cord-005453-4057qib7 2462 15 for for IN cord-005453-4057qib7 2462 16 53 53 CD cord-005453-4057qib7 2462 17 % % NN cord-005453-4057qib7 2462 18 of of IN cord-005453-4057qib7 2462 19 patients patient NNS cord-005453-4057qib7 2462 20 aged age VBN cord-005453-4057qib7 2462 21 65 65 CD cord-005453-4057qib7 2462 22 - - SYM cord-005453-4057qib7 2462 23 69 69 CD cord-005453-4057qib7 2462 24 . . . cord-005453-4057qib7 2463 1 The the DT cord-005453-4057qib7 2463 2 outcomes outcome NNS cord-005453-4057qib7 2463 3 of of IN cord-005453-4057qib7 2463 4 the the DT cord-005453-4057qib7 2463 5 following following JJ cord-005453-4057qib7 2463 6 three three CD cord-005453-4057qib7 2463 7 groups group NNS cord-005453-4057qib7 2463 8 of of IN cord-005453-4057qib7 2463 9 patients patient NNS cord-005453-4057qib7 2463 10 were be VBD cord-005453-4057qib7 2463 11 compared compare VBN cord-005453-4057qib7 2463 12 : : : cord-005453-4057qib7 2463 13 A a LS cord-005453-4057qib7 2463 14 ) ) -RRB- cord-005453-4057qib7 2463 15 age age NN cord-005453-4057qib7 2463 16 ≥ ≥ CD cord-005453-4057qib7 2463 17 65 65 CD cord-005453-4057qib7 2463 18 ; ; : cord-005453-4057qib7 2463 19 without without IN cord-005453-4057qib7 2463 20 dose dose NN cord-005453-4057qib7 2463 21 reduction reduction NN cord-005453-4057qib7 2463 22 , , , cord-005453-4057qib7 2463 23 B b NN cord-005453-4057qib7 2463 24 ) ) -RRB- cord-005453-4057qib7 2463 25 age age NN cord-005453-4057qib7 2463 26 65 65 CD cord-005453-4057qib7 2463 27 - - SYM cord-005453-4057qib7 2463 28 69 69 CD cord-005453-4057qib7 2463 29 ; ; : cord-005453-4057qib7 2463 30 with with IN cord-005453-4057qib7 2463 31 dose dose JJ cord-005453-4057qib7 2463 32 reduction reduction NN cord-005453-4057qib7 2463 33 and and CC cord-005453-4057qib7 2463 34 C c NN cord-005453-4057qib7 2463 35 ) ) -RRB- cord-005453-4057qib7 2463 36 age age NN cord-005453-4057qib7 2463 37 ≥ ≥ CD cord-005453-4057qib7 2463 38 70 70 CD cord-005453-4057qib7 2463 39 ; ; : cord-005453-4057qib7 2463 40 with with IN cord-005453-4057qib7 2463 41 dose dose JJ cord-005453-4057qib7 2463 42 reduction reduction NN cord-005453-4057qib7 2463 43 ( ( -LRB- cord-005453-4057qib7 2463 44 table table NN cord-005453-4057qib7 2463 45 1 1 CD cord-005453-4057qib7 2463 46 ) ) -RRB- cord-005453-4057qib7 2463 47 . . . cord-005453-4057qib7 2464 1 Only only RB cord-005453-4057qib7 2464 2 one one CD cord-005453-4057qib7 2464 3 patient patient NN cord-005453-4057qib7 2464 4 aged age VBD cord-005453-4057qib7 2464 5 70 70 CD cord-005453-4057qib7 2464 6 received receive VBN cord-005453-4057qib7 2464 7 full full JJ cord-005453-4057qib7 2464 8 - - HYPH cord-005453-4057qib7 2464 9 dose dose NN cord-005453-4057qib7 2464 10 conditioning conditioning NN cord-005453-4057qib7 2464 11 . . . cord-005453-4057qib7 2465 1 There there EX cord-005453-4057qib7 2465 2 was be VBD cord-005453-4057qib7 2465 3 no no DT cord-005453-4057qib7 2465 4 significant significant JJ cord-005453-4057qib7 2465 5 difference difference NN cord-005453-4057qib7 2465 6 between between IN cord-005453-4057qib7 2465 7 the the DT cord-005453-4057qib7 2465 8 groups group NNS cord-005453-4057qib7 2465 9 in in IN cord-005453-4057qib7 2465 10 the the DT cord-005453-4057qib7 2465 11 number number NN cord-005453-4057qib7 2465 12 of of IN cord-005453-4057qib7 2465 13 previous previous JJ cord-005453-4057qib7 2465 14 chemotherapy chemotherapy NN cord-005453-4057qib7 2465 15 cycles cycle NNS cord-005453-4057qib7 2465 16 ( ( -LRB- cord-005453-4057qib7 2465 17 median median JJ cord-005453-4057qib7 2465 18 2 2 CD cord-005453-4057qib7 2465 19 , , , cord-005453-4057qib7 2465 20 range range NN cord-005453-4057qib7 2465 21 1 1 CD cord-005453-4057qib7 2465 22 - - SYM cord-005453-4057qib7 2465 23 3 3 CD cord-005453-4057qib7 2465 24 ) ) -RRB- cord-005453-4057qib7 2465 25 . . . cord-005453-4057qib7 2466 1 However however RB cord-005453-4057qib7 2466 2 , , , cord-005453-4057qib7 2466 3 significantly significantly RB cord-005453-4057qib7 2466 4 more more JJR cord-005453-4057qib7 2466 5 patients patient NNS cord-005453-4057qib7 2466 6 at at IN cord-005453-4057qib7 2466 7 the the DT cord-005453-4057qib7 2466 8 age age NN cord-005453-4057qib7 2466 9 of of IN cord-005453-4057qib7 2466 10 65 65 CD cord-005453-4057qib7 2466 11 - - SYM cord-005453-4057qib7 2466 12 69 69 CD cord-005453-4057qib7 2466 13 were be VBD cord-005453-4057qib7 2466 14 in in IN cord-005453-4057qib7 2466 15 complete complete JJ cord-005453-4057qib7 2466 16 remission remission NN cord-005453-4057qib7 2467 1 ( ( -LRB- cord-005453-4057qib7 2467 2 CR CR NNP cord-005453-4057qib7 2467 3 ) ) -RRB- cord-005453-4057qib7 2467 4 pre pre JJ cord-005453-4057qib7 2467 5 - - NN cord-005453-4057qib7 2467 6 transplant transplant NN cord-005453-4057qib7 2467 7 in in IN cord-005453-4057qib7 2467 8 both both CC cord-005453-4057qib7 2467 9 full full JJ cord-005453-4057qib7 2467 10 and and CC cord-005453-4057qib7 2467 11 reduced reduce VBN cord-005453-4057qib7 2467 12 - - HYPH cord-005453-4057qib7 2467 13 dose dose NN cord-005453-4057qib7 2467 14 conditioning conditioning NN cord-005453-4057qib7 2467 15 groups group NNS cord-005453-4057qib7 2467 16 ( ( -LRB- cord-005453-4057qib7 2467 17 A a NN cord-005453-4057qib7 2467 18 and and CC cord-005453-4057qib7 2467 19 B b NN cord-005453-4057qib7 2467 20 ) ) -RRB- cord-005453-4057qib7 2467 21 . . . cord-005453-4057qib7 2468 1 No no DT cord-005453-4057qib7 2468 2 significant significant JJ cord-005453-4057qib7 2468 3 intergroup intergroup NN cord-005453-4057qib7 2468 4 differences difference NNS cord-005453-4057qib7 2468 5 were be VBD cord-005453-4057qib7 2468 6 observed observe VBN cord-005453-4057qib7 2468 7 in in IN cord-005453-4057qib7 2468 8 the the DT cord-005453-4057qib7 2468 9 occurrence occurrence NN cord-005453-4057qib7 2468 10 of of IN cord-005453-4057qib7 2468 11 complications complication NNS cord-005453-4057qib7 2468 12 ( ( -LRB- cord-005453-4057qib7 2468 13 mucositis mucositis NNP cord-005453-4057qib7 2468 14 and and CC cord-005453-4057qib7 2468 15 infections infection NNS cord-005453-4057qib7 2468 16 ) ) -RRB- cord-005453-4057qib7 2468 17 , , , cord-005453-4057qib7 2468 18 day day NN cord-005453-4057qib7 2468 19 30 30 CD cord-005453-4057qib7 2468 20 transplantrelated transplantrelate VBN cord-005453-4057qib7 2468 21 mortality mortality NN cord-005453-4057qib7 2468 22 ( ( -LRB- cord-005453-4057qib7 2468 23 TRM TRM NNP cord-005453-4057qib7 2468 24 ) ) -RRB- cord-005453-4057qib7 2468 25 or or CC cord-005453-4057qib7 2468 26 engraftment engraftment NNP cord-005453-4057qib7 2468 27 day day NNP cord-005453-4057qib7 2468 28 . . . cord-005453-4057qib7 2469 1 Similarly similarly RB cord-005453-4057qib7 2469 2 , , , cord-005453-4057qib7 2469 3 no no DT cord-005453-4057qib7 2469 4 significant significant JJ cord-005453-4057qib7 2469 5 differences difference NNS cord-005453-4057qib7 2469 6 were be VBD cord-005453-4057qib7 2469 7 found find VBN cord-005453-4057qib7 2469 8 either either CC cord-005453-4057qib7 2469 9 in in IN cord-005453-4057qib7 2469 10 the the DT cord-005453-4057qib7 2469 11 1-year 1-year CD cord-005453-4057qib7 2469 12 progression progression NN cord-005453-4057qib7 2469 13 - - HYPH cord-005453-4057qib7 2469 14 free free JJ cord-005453-4057qib7 2469 15 survival survival NN cord-005453-4057qib7 2469 16 ( ( -LRB- cord-005453-4057qib7 2469 17 PFS PFS NNP cord-005453-4057qib7 2469 18 ) ) -RRB- cord-005453-4057qib7 2469 19 , , , cord-005453-4057qib7 2469 20 which which WDT cord-005453-4057qib7 2469 21 was be VBD cord-005453-4057qib7 2469 22 50 50 CD cord-005453-4057qib7 2469 23 % % NN cord-005453-4057qib7 2469 24 , , , cord-005453-4057qib7 2469 25 64 64 CD cord-005453-4057qib7 2469 26 % % NN cord-005453-4057qib7 2469 27 and and CC cord-005453-4057qib7 2469 28 50 50 CD cord-005453-4057qib7 2469 29 % % NN cord-005453-4057qib7 2469 30 , , , cord-005453-4057qib7 2469 31 or or CC cord-005453-4057qib7 2469 32 1-year 1-year CD cord-005453-4057qib7 2469 33 non non JJ cord-005453-4057qib7 2469 34 - - JJ cord-005453-4057qib7 2469 35 relapse relapse JJ cord-005453-4057qib7 2469 36 mortality mortality NN cord-005453-4057qib7 2469 37 ( ( -LRB- cord-005453-4057qib7 2469 38 NRM NRM NNP cord-005453-4057qib7 2469 39 ) ) -RRB- cord-005453-4057qib7 2469 40 , , , cord-005453-4057qib7 2469 41 which which WDT cord-005453-4057qib7 2469 42 was be VBD cord-005453-4057qib7 2469 43 17 17 CD cord-005453-4057qib7 2469 44 % % NN cord-005453-4057qib7 2469 45 , , , cord-005453-4057qib7 2469 46 7 7 CD cord-005453-4057qib7 2469 47 % % NN cord-005453-4057qib7 2469 48 and and CC cord-005453-4057qib7 2469 49 10 10 CD cord-005453-4057qib7 2469 50 % % NN cord-005453-4057qib7 2469 51 , , , cord-005453-4057qib7 2469 52 respectively respectively RB cord-005453-4057qib7 2469 53 for for IN cord-005453-4057qib7 2469 54 groups group NNS cord-005453-4057qib7 2469 55 A A NNP cord-005453-4057qib7 2469 56 , , , cord-005453-4057qib7 2469 57 B B NNP cord-005453-4057qib7 2469 58 and and CC cord-005453-4057qib7 2469 59 C. c. NN cord-005453-4057qib7 2470 1 The the DT cord-005453-4057qib7 2470 2 1-year 1-year CD cord-005453-4057qib7 2470 3 overall overall JJ cord-005453-4057qib7 2470 4 survival survival NN cord-005453-4057qib7 2470 5 ( ( -LRB- cord-005453-4057qib7 2470 6 OS OS NNP cord-005453-4057qib7 2470 7 ) ) -RRB- cord-005453-4057qib7 2470 8 tended tend VBD cord-005453-4057qib7 2470 9 to to TO cord-005453-4057qib7 2470 10 be be VB cord-005453-4057qib7 2470 11 higher high JJR cord-005453-4057qib7 2470 12 in in IN cord-005453-4057qib7 2470 13 group group NN cord-005453-4057qib7 2470 14 B b NN cord-005453-4057qib7 2470 15 ( ( -LRB- cord-005453-4057qib7 2470 16 85 85 CD cord-005453-4057qib7 2470 17 % % NN cord-005453-4057qib7 2470 18 ) ) -RRB- cord-005453-4057qib7 2470 19 , , , cord-005453-4057qib7 2470 20 compared compare VBN cord-005453-4057qib7 2470 21 to to IN cord-005453-4057qib7 2470 22 groups group NNS cord-005453-4057qib7 2470 23 A A NNP cord-005453-4057qib7 2470 24 ( ( -LRB- cord-005453-4057qib7 2470 25 66 66 CD cord-005453-4057qib7 2470 26 % % NN cord-005453-4057qib7 2470 27 ) ) -RRB- cord-005453-4057qib7 2470 28 and and CC cord-005453-4057qib7 2470 29 C C NNP cord-005453-4057qib7 2470 30 ( ( -LRB- cord-005453-4057qib7 2470 31 70 70 CD cord-005453-4057qib7 2470 32 % % NN cord-005453-4057qib7 2470 33 ) ) -RRB- cord-005453-4057qib7 2470 34 . . . cord-005453-4057qib7 2471 1 Conclusions conclusion NNS cord-005453-4057qib7 2471 2 : : : cord-005453-4057qib7 2472 1 BEAM BEAM NNP cord-005453-4057qib7 2472 2 / / SYM cord-005453-4057qib7 2472 3 BEAC BEAC NNP cord-005453-4057qib7 2472 4 conditioning conditioning NN cord-005453-4057qib7 2472 5 dose dose NN cord-005453-4057qib7 2472 6 reduction reduction NN cord-005453-4057qib7 2472 7 was be VBD cord-005453-4057qib7 2472 8 not not RB cord-005453-4057qib7 2472 9 found find VBN cord-005453-4057qib7 2472 10 to to TO cord-005453-4057qib7 2472 11 adversely adversely RB cord-005453-4057qib7 2472 12 affect affect VB cord-005453-4057qib7 2472 13 1-year 1-year CD cord-005453-4057qib7 2472 14 PFS PFS NNP cord-005453-4057qib7 2472 15 and and CC cord-005453-4057qib7 2472 16 OS OS NNP cord-005453-4057qib7 2472 17 rates rate NNS cord-005453-4057qib7 2472 18 . . . cord-005453-4057qib7 2473 1 Despite despite IN cord-005453-4057qib7 2473 2 the the DT cord-005453-4057qib7 2473 3 fact fact NN cord-005453-4057qib7 2473 4 that that IN cord-005453-4057qib7 2473 5 2/3 2/3 CD cord-005453-4057qib7 2473 6 of of IN cord-005453-4057qib7 2473 7 the the DT cord-005453-4057qib7 2473 8 patients patient NNS cord-005453-4057qib7 2473 9 in in IN cord-005453-4057qib7 2473 10 the the DT cord-005453-4057qib7 2473 11 age age NN cord-005453-4057qib7 2473 12 group group NN cord-005453-4057qib7 2473 13 ≥ ≥ CD cord-005453-4057qib7 2473 14 70 70 CD cord-005453-4057qib7 2473 15 underwent undergo VBD cord-005453-4057qib7 2473 16 ASCT ASCT NNP cord-005453-4057qib7 2473 17 in in IN cord-005453-4057qib7 2473 18 partial partial JJ cord-005453-4057qib7 2473 19 remission remission NN cord-005453-4057qib7 2473 20 and and CC cord-005453-4057qib7 2473 21 had have VBD cord-005453-4057qib7 2473 22 dose dose JJ cord-005453-4057qib7 2473 23 reduction reduction NN cord-005453-4057qib7 2473 24 , , , cord-005453-4057qib7 2473 25 theier theier NNPS cord-005453-4057qib7 2473 26 achieved achieve VBD cord-005453-4057qib7 2473 27 TRM TRM NNP cord-005453-4057qib7 2473 28 , , , cord-005453-4057qib7 2473 29 PFS PFS NNP cord-005453-4057qib7 2473 30 and and CC cord-005453-4057qib7 2473 31 OS OS NNP cord-005453-4057qib7 2473 32 rates rate NNS cord-005453-4057qib7 2473 33 were be VBD cord-005453-4057qib7 2473 34 similar similar JJ cord-005453-4057qib7 2473 35 to to IN cord-005453-4057qib7 2473 36 those those DT cord-005453-4057qib7 2473 37 of of IN cord-005453-4057qib7 2473 38 patients patient NNS cord-005453-4057qib7 2473 39 aged age VBN cord-005453-4057qib7 2473 40 65 65 CD cord-005453-4057qib7 2473 41 - - SYM cord-005453-4057qib7 2473 42 69 69 CD cord-005453-4057qib7 2473 43 . . . cord-005453-4057qib7 2474 1 BEAM BEAM NNP cord-005453-4057qib7 2474 2 / / SYM cord-005453-4057qib7 2474 3 BEAC BEAC NNP cord-005453-4057qib7 2474 4 conditioning conditioning NN cord-005453-4057qib7 2474 5 at at IN cord-005453-4057qib7 2474 6 a a DT cord-005453-4057qib7 2474 7 75%dose 75%dose CD cord-005453-4057qib7 2474 8 may may MD cord-005453-4057qib7 2474 9 be be VB cord-005453-4057qib7 2474 10 a a DT cord-005453-4057qib7 2474 11 suitable suitable JJ cord-005453-4057qib7 2474 12 option option NN cord-005453-4057qib7 2474 13 for for IN cord-005453-4057qib7 2474 14 patients patient NNS cord-005453-4057qib7 2474 15 in in IN cord-005453-4057qib7 2474 16 their -PRON- PRP$ cord-005453-4057qib7 2474 17 seventh seventh JJ cord-005453-4057qib7 2474 18 decade decade NN cord-005453-4057qib7 2474 19 requiring require VBG cord-005453-4057qib7 2474 20 ASCT ASCT NNP cord-005453-4057qib7 2474 21 . . . cord-005453-4057qib7 2475 1 This this DT cord-005453-4057qib7 2475 2 strategy strategy NN cord-005453-4057qib7 2475 3 should should MD cord-005453-4057qib7 2475 4 be be VB cord-005453-4057qib7 2475 5 further further RB cord-005453-4057qib7 2475 6 evaluated evaluate VBN cord-005453-4057qib7 2475 7 in in IN cord-005453-4057qib7 2475 8 prospective prospective JJ cord-005453-4057qib7 2475 9 clinical clinical JJ cord-005453-4057qib7 2475 10 trials trial NNS cord-005453-4057qib7 2475 11 . . . cord-005453-4057qib7 2476 1 Background background NN cord-005453-4057qib7 2476 2 : : : cord-005453-4057qib7 2477 1 The the DT cord-005453-4057qib7 2477 2 transplant transplant NN cord-005453-4057qib7 2477 3 related relate VBN cord-005453-4057qib7 2477 4 mortality mortality NN cord-005453-4057qib7 2477 5 in in IN cord-005453-4057qib7 2477 6 autologous autologous JJ cord-005453-4057qib7 2477 7 transplants transplant NNS cord-005453-4057qib7 2477 8 for for IN cord-005453-4057qib7 2477 9 lymphoma lymphoma NN cord-005453-4057qib7 2477 10 and and CC cord-005453-4057qib7 2477 11 multiple multiple JJ cord-005453-4057qib7 2477 12 myeloma myeloma NN cord-005453-4057qib7 2477 13 , , , cord-005453-4057qib7 2477 14 reported report VBD cord-005453-4057qib7 2477 15 worldwide worldwide RB cord-005453-4057qib7 2477 16 ranges range VBZ cord-005453-4057qib7 2477 17 from from IN cord-005453-4057qib7 2477 18 0 0 CD cord-005453-4057qib7 2477 19 - - SYM cord-005453-4057qib7 2477 20 5 5 CD cord-005453-4057qib7 2477 21 % % NN cord-005453-4057qib7 2477 22 . . . cord-005453-4057qib7 2478 1 From from IN cord-005453-4057qib7 2478 2 2004 2004 CD cord-005453-4057qib7 2478 3 - - SYM cord-005453-4057qib7 2478 4 2015 2015 CD cord-005453-4057qib7 2478 5 , , , cord-005453-4057qib7 2478 6 the the DT cord-005453-4057qib7 2478 7 TRM TRM NNP cord-005453-4057qib7 2478 8 at at IN cord-005453-4057qib7 2478 9 our -PRON- PRP$ cord-005453-4057qib7 2478 10 center center NN cord-005453-4057qib7 2478 11 for for IN cord-005453-4057qib7 2478 12 these these DT cord-005453-4057qib7 2478 13 two two CD cord-005453-4057qib7 2478 14 diseases disease NNS cord-005453-4057qib7 2478 15 was be VBD cord-005453-4057qib7 2478 16 approximately approximately RB cord-005453-4057qib7 2478 17 20 20 CD cord-005453-4057qib7 2478 18 % % NN cord-005453-4057qib7 2478 19 . . . cord-005453-4057qib7 2479 1 We -PRON- PRP cord-005453-4057qib7 2479 2 introduced introduce VBD cord-005453-4057qib7 2479 3 changes change NNS cord-005453-4057qib7 2479 4 in in IN cord-005453-4057qib7 2479 5 mobilization mobilization NN cord-005453-4057qib7 2479 6 schedule schedule NN cord-005453-4057qib7 2479 7 , , , cord-005453-4057qib7 2479 8 conditioning conditioning NN cord-005453-4057qib7 2479 9 regimens regimen NNS cord-005453-4057qib7 2479 10 and and CC cord-005453-4057qib7 2479 11 drug drug NN cord-005453-4057qib7 2479 12 dosages dosage NNS cord-005453-4057qib7 2479 13 to to TO cord-005453-4057qib7 2479 14 determine determine VB cord-005453-4057qib7 2479 15 whether whether IN cord-005453-4057qib7 2479 16 these these DT cord-005453-4057qib7 2479 17 changes change NNS cord-005453-4057qib7 2479 18 affected affect VBD cord-005453-4057qib7 2479 19 the the DT cord-005453-4057qib7 2479 20 transplant transplant NN cord-005453-4057qib7 2479 21 related relate VBN cord-005453-4057qib7 2479 22 mortality mortality NN cord-005453-4057qib7 2479 23 and and CC cord-005453-4057qib7 2479 24 overall overall JJ cord-005453-4057qib7 2479 25 survival survival NN cord-005453-4057qib7 2479 26 . . . cord-005453-4057qib7 2480 1 Methods method NNS cord-005453-4057qib7 2480 2 : : : cord-005453-4057qib7 2481 1 From from IN cord-005453-4057qib7 2481 2 April April NNP cord-005453-4057qib7 2481 3 2004-December 2004-december CD cord-005453-4057qib7 2481 4 2015 2015 CD cord-005453-4057qib7 2481 5 , , , cord-005453-4057qib7 2481 6 we -PRON- PRP cord-005453-4057qib7 2481 7 used use VBD cord-005453-4057qib7 2481 8 BEAM BEAM NNP cord-005453-4057qib7 2482 1 ( ( -LRB- cord-005453-4057qib7 2482 2 BCNU BCNU NNP cord-005453-4057qib7 2482 3 : : : cord-005453-4057qib7 2483 1 300 300 CD cord-005453-4057qib7 2483 2 mg mg NNP cord-005453-4057qib7 2483 3 / / SYM cord-005453-4057qib7 2483 4 m m NNP cord-005453-4057qib7 2483 5 2 2 CD cord-005453-4057qib7 2483 6 on on IN cord-005453-4057qib7 2483 7 day day NN cord-005453-4057qib7 2483 8 -6 -6 NNP cord-005453-4057qib7 2483 9 ; ; . cord-005453-4057qib7 2484 1 Etoposide etoposide RB cord-005453-4057qib7 2484 2 200 200 CD cord-005453-4057qib7 2484 3 mg/ mg/ NN cord-005453-4057qib7 2484 4 m m CD cord-005453-4057qib7 2484 5 2 2 CD cord-005453-4057qib7 2484 6 on on IN cord-005453-4057qib7 2484 7 days day NNS cord-005453-4057qib7 2484 8 -5 -5 JJ cord-005453-4057qib7 2484 9 to to IN cord-005453-4057qib7 2485 1 -2 -2 NNP cord-005453-4057qib7 2485 2 , , , cord-005453-4057qib7 2485 3 Cytarabine Cytarabine NNP cord-005453-4057qib7 2485 4 200 200 CD cord-005453-4057qib7 2485 5 mg mg NNP cord-005453-4057qib7 2485 6 / / SYM cord-005453-4057qib7 2485 7 m m NNP cord-005453-4057qib7 2485 8 2 2 CD cord-005453-4057qib7 2485 9 on on IN cord-005453-4057qib7 2485 10 days day NNS cord-005453-4057qib7 2485 11 -5 -5 NNP cord-005453-4057qib7 2486 1 to to IN cord-005453-4057qib7 2486 2 -2 -2 CD cord-005453-4057qib7 2486 3 and and CC cord-005453-4057qib7 2486 4 Melphalan Melphalan NNP cord-005453-4057qib7 2487 1 140mg 140mg NNP cord-005453-4057qib7 2487 2 / / SYM cord-005453-4057qib7 2487 3 m m NNP cord-005453-4057qib7 2487 4 2 2 CD cord-005453-4057qib7 2487 5 on on IN cord-005453-4057qib7 2487 6 day day NN cord-005453-4057qib7 2487 7 -1 -1 . cord-005453-4057qib7 2488 1 as as IN cord-005453-4057qib7 2488 2 conditioning conditioning NN cord-005453-4057qib7 2488 3 chemotherapy chemotherapy NN cord-005453-4057qib7 2488 4 for for IN cord-005453-4057qib7 2488 5 patients patient NNS cord-005453-4057qib7 2488 6 admitted admit VBN cord-005453-4057qib7 2488 7 in in IN cord-005453-4057qib7 2488 8 transplant transplant NN cord-005453-4057qib7 2488 9 unit unit NN cord-005453-4057qib7 2488 10 for for IN cord-005453-4057qib7 2488 11 autologous autologous JJ cord-005453-4057qib7 2488 12 transplants transplant NNS cord-005453-4057qib7 2488 13 in in IN cord-005453-4057qib7 2488 14 Hodgkin Hodgkin NNP cord-005453-4057qib7 2488 15 's 's POS cord-005453-4057qib7 2488 16 and and CC cord-005453-4057qib7 2488 17 Non Non NNP cord-005453-4057qib7 2488 18 - - NNP cord-005453-4057qib7 2488 19 Hodgkin Hodgkin NNP cord-005453-4057qib7 2488 20 's 's POS cord-005453-4057qib7 2488 21 Lymphoma Lymphoma NNP cord-005453-4057qib7 2488 22 . . . cord-005453-4057qib7 2489 1 In in IN cord-005453-4057qib7 2489 2 patients patient NNS cord-005453-4057qib7 2489 3 with with IN cord-005453-4057qib7 2489 4 multiple multiple JJ cord-005453-4057qib7 2489 5 myeloma myeloma NN cord-005453-4057qib7 2489 6 high high JJ cord-005453-4057qib7 2489 7 dose dose NN cord-005453-4057qib7 2489 8 Melphalan Melphalan NNP cord-005453-4057qib7 2489 9 ( ( -LRB- cord-005453-4057qib7 2489 10 200mg 200mg NNP cord-005453-4057qib7 2489 11 / / SYM cord-005453-4057qib7 2489 12 m m NNP cord-005453-4057qib7 2489 13 2 2 CD cord-005453-4057qib7 2489 14 ) ) -RRB- cord-005453-4057qib7 2489 15 was be VBD cord-005453-4057qib7 2489 16 used use VBN cord-005453-4057qib7 2489 17 . . . cord-005453-4057qib7 2490 1 The the DT cord-005453-4057qib7 2490 2 mobilization mobilization NN cord-005453-4057qib7 2490 3 protocol protocol NN cord-005453-4057qib7 2490 4 consisted consist VBD cord-005453-4057qib7 2490 5 of of IN cord-005453-4057qib7 2490 6 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 2490 7 1.5gm 1.5gm NNP cord-005453-4057qib7 2490 8 / / SYM cord-005453-4057qib7 2490 9 m m NN cord-005453-4057qib7 2490 10 2 2 CD cord-005453-4057qib7 2490 11 followed follow VBN cord-005453-4057qib7 2490 12 by by IN cord-005453-4057qib7 2490 13 GCSF GCSF NNP cord-005453-4057qib7 2490 14 5μgm 5μgm CD cord-005453-4057qib7 2491 1 /kg /kg NFP cord-005453-4057qib7 2491 2 twice twice RB cord-005453-4057qib7 2491 3 daily daily RB cord-005453-4057qib7 2491 4 till till IN cord-005453-4057qib7 2491 5 stem stem NN cord-005453-4057qib7 2491 6 cell cell NN cord-005453-4057qib7 2491 7 collection collection NN cord-005453-4057qib7 2491 8 was be VBD cord-005453-4057qib7 2491 9 completed complete VBN cord-005453-4057qib7 2491 10 . . . cord-005453-4057qib7 2492 1 From from IN cord-005453-4057qib7 2492 2 January January NNP cord-005453-4057qib7 2492 3 2016 2016 CD cord-005453-4057qib7 2492 4 , , , cord-005453-4057qib7 2492 5 we -PRON- PRP cord-005453-4057qib7 2492 6 changed change VBD cord-005453-4057qib7 2492 7 the the DT cord-005453-4057qib7 2492 8 BEAM BEAM NNP cord-005453-4057qib7 2492 9 protocol protocol NN cord-005453-4057qib7 2492 10 to to IN cord-005453-4057qib7 2492 11 BendaEAM BendaEAM NNP cord-005453-4057qib7 2492 12 with with IN cord-005453-4057qib7 2492 13 dose dose NN cord-005453-4057qib7 2492 14 modifications modification NNS cord-005453-4057qib7 2492 15 that that WDT cord-005453-4057qib7 2492 16 included include VBD cord-005453-4057qib7 2492 17 : : : cord-005453-4057qib7 2492 18 bendamustine bendamustine NNP cord-005453-4057qib7 2492 19 150mg 150mg NNP cord-005453-4057qib7 2492 20 / / SYM cord-005453-4057qib7 2492 21 m m NNP cord-005453-4057qib7 2492 22 2 2 CD cord-005453-4057qib7 2492 23 on on IN cord-005453-4057qib7 2492 24 days day NNS cord-005453-4057qib7 2492 25 -5 -5 NNP cord-005453-4057qib7 2492 26 and and CC cord-005453-4057qib7 2492 27 -4 -4 NNP cord-005453-4057qib7 2492 28 , , , cord-005453-4057qib7 2492 29 cytarabine cytarabine NNP cord-005453-4057qib7 2492 30 150mg 150mg NNP cord-005453-4057qib7 2492 31 / / SYM cord-005453-4057qib7 2492 32 m m NN cord-005453-4057qib7 2492 33 2 2 CD cord-005453-4057qib7 2492 34 on on IN cord-005453-4057qib7 2492 35 days day NNS cord-005453-4057qib7 2492 36 -5 -5 JJ cord-005453-4057qib7 2492 37 to to IN cord-005453-4057qib7 2492 38 -2 -2 CD cord-005453-4057qib7 2492 39 , , , cord-005453-4057qib7 2492 40 etoposide etoposide JJ cord-005453-4057qib7 2492 41 150mg 150mg NNP cord-005453-4057qib7 2492 42 / / SYM cord-005453-4057qib7 2492 43 m m NN cord-005453-4057qib7 2492 44 2 2 CD cord-005453-4057qib7 2492 45 on on IN cord-005453-4057qib7 2492 46 days day NNS cord-005453-4057qib7 2492 47 -5 -5 JJ cord-005453-4057qib7 2492 48 to to IN cord-005453-4057qib7 2492 49 -2 -2 CD cord-005453-4057qib7 2492 50 and and CC cord-005453-4057qib7 2492 51 melphalan melphalan NNP cord-005453-4057qib7 2492 52 100mg 100mg NNP cord-005453-4057qib7 2492 53 / / SYM cord-005453-4057qib7 2492 54 m m NNP cord-005453-4057qib7 2492 55 2 2 CD cord-005453-4057qib7 2492 56 on on IN cord-005453-4057qib7 2492 57 day day NN cord-005453-4057qib7 2492 58 -1 -1 CD cord-005453-4057qib7 2492 59 . . . cord-005453-4057qib7 2493 1 For for IN cord-005453-4057qib7 2493 2 multiple multiple JJ cord-005453-4057qib7 2493 3 myeloma myeloma NN cord-005453-4057qib7 2493 4 Melphalan Melphalan NNP cord-005453-4057qib7 2493 5 was be VBD cord-005453-4057qib7 2493 6 reduced reduce VBN cord-005453-4057qib7 2493 7 to to IN cord-005453-4057qib7 2493 8 150mg 150mg NNP cord-005453-4057qib7 2493 9 / / SYM cord-005453-4057qib7 2493 10 m m NN cord-005453-4057qib7 2493 11 2 2 CD cord-005453-4057qib7 2493 12 . . . cord-005453-4057qib7 2494 1 We -PRON- PRP cord-005453-4057qib7 2494 2 used use VBD cord-005453-4057qib7 2494 3 only only RB cord-005453-4057qib7 2494 4 GCSF GCSF NNP cord-005453-4057qib7 2494 5 for for IN cord-005453-4057qib7 2494 6 mobilization mobilization NN cord-005453-4057qib7 2494 7 of of IN cord-005453-4057qib7 2494 8 stem stem NN cord-005453-4057qib7 2494 9 cells cell NNS cord-005453-4057qib7 2494 10 , , , cord-005453-4057qib7 2494 11 which which WDT cord-005453-4057qib7 2494 12 was be VBD cord-005453-4057qib7 2494 13 continued continue VBN cord-005453-4057qib7 2494 14 till till IN cord-005453-4057qib7 2494 15 stem stem NN cord-005453-4057qib7 2494 16 cell cell NN cord-005453-4057qib7 2494 17 harvest harvest NN cord-005453-4057qib7 2494 18 was be VBD cord-005453-4057qib7 2494 19 complete complete JJ cord-005453-4057qib7 2494 20 . . . cord-005453-4057qib7 2495 1 Response response NN cord-005453-4057qib7 2495 2 to to IN cord-005453-4057qib7 2495 3 treatment treatment NN cord-005453-4057qib7 2495 4 was be VBD cord-005453-4057qib7 2495 5 evaluated evaluate VBN cord-005453-4057qib7 2495 6 by by IN cord-005453-4057qib7 2495 7 comparing compare VBG cord-005453-4057qib7 2495 8 TRM TRM NNP cord-005453-4057qib7 2495 9 and and CC cord-005453-4057qib7 2495 10 overall overall JJ cord-005453-4057qib7 2495 11 survival survival NN cord-005453-4057qib7 2495 12 for for IN cord-005453-4057qib7 2495 13 two two CD cord-005453-4057qib7 2495 14 time time NN cord-005453-4057qib7 2495 15 periods period NNS cord-005453-4057qib7 2495 16 : : : cord-005453-4057qib7 2495 17 2004 2004 CD cord-005453-4057qib7 2495 18 - - SYM cord-005453-4057qib7 2495 19 2015 2015 CD cord-005453-4057qib7 2495 20 and and CC cord-005453-4057qib7 2495 21 from from IN cord-005453-4057qib7 2495 22 2016 2016 CD cord-005453-4057qib7 2495 23 till till IN cord-005453-4057qib7 2495 24 date date NN cord-005453-4057qib7 2495 25 . . . cord-005453-4057qib7 2496 1 Results result NNS cord-005453-4057qib7 2496 2 : : : cord-005453-4057qib7 2497 1 From from IN cord-005453-4057qib7 2497 2 April April NNP cord-005453-4057qib7 2497 3 2004 2004 CD cord-005453-4057qib7 2497 4 till till IN cord-005453-4057qib7 2497 5 December December NNP cord-005453-4057qib7 2497 6 2015 2015 CD cord-005453-4057qib7 2497 7 , , , cord-005453-4057qib7 2497 8 n=78 n=78 IN cord-005453-4057qib7 2497 9 autologous autologous JJ cord-005453-4057qib7 2497 10 transplants transplant NNS cord-005453-4057qib7 2497 11 were be VBD cord-005453-4057qib7 2497 12 performed perform VBN cord-005453-4057qib7 2497 13 . . . cord-005453-4057qib7 2498 1 The the DT cord-005453-4057qib7 2498 2 male male JJ cord-005453-4057qib7 2498 3 : : : cord-005453-4057qib7 2498 4 female female JJ cord-005453-4057qib7 2498 5 ratio ratio NN cord-005453-4057qib7 2498 6 was be VBD cord-005453-4057qib7 2498 7 2.4:1 2.4:1 CD cord-005453-4057qib7 2498 8 . . . cord-005453-4057qib7 2499 1 Fifty fifty CD cord-005453-4057qib7 2499 2 seven seven CD cord-005453-4057qib7 2499 3 patients patient NNS cord-005453-4057qib7 2499 4 underwent undergo VBD cord-005453-4057qib7 2499 5 transplant transplant NN cord-005453-4057qib7 2499 6 for for IN cord-005453-4057qib7 2499 7 lymphomas lymphoma NNS cord-005453-4057qib7 2499 8 , , , cord-005453-4057qib7 2499 9 n=16 n=16 NNP cord-005453-4057qib7 2499 10 for for IN cord-005453-4057qib7 2499 11 multiple multiple JJ cord-005453-4057qib7 2499 12 myeloma myeloma NN cord-005453-4057qib7 2499 13 and and CC cord-005453-4057qib7 2499 14 n=5 n=5 JJ cord-005453-4057qib7 2499 15 for for IN cord-005453-4057qib7 2499 16 other other JJ cord-005453-4057qib7 2499 17 diagnosis diagnosis NN cord-005453-4057qib7 2499 18 . . . cord-005453-4057qib7 2500 1 Median median JJ cord-005453-4057qib7 2500 2 age age NN cord-005453-4057qib7 2500 3 was be VBD cord-005453-4057qib7 2500 4 23±14.6 23±14.6 CD cord-005453-4057qib7 2500 5 ( ( -LRB- cord-005453-4057qib7 2500 6 2 2 CD cord-005453-4057qib7 2500 7 - - SYM cord-005453-4057qib7 2500 8 64 64 CD cord-005453-4057qib7 2500 9 years year NNS cord-005453-4057qib7 2500 10 ) ) -RRB- cord-005453-4057qib7 2500 11 . . . cord-005453-4057qib7 2501 1 The the DT cord-005453-4057qib7 2501 2 mean mean JJ cord-005453-4057qib7 2501 3 MNC MNC NNP cord-005453-4057qib7 2501 4 was be VBD cord-005453-4057qib7 2501 5 4.7 4.7 CD cord-005453-4057qib7 2501 6 × × NN cord-005453-4057qib7 2501 7 10 10 CD cord-005453-4057qib7 2501 8 8 8 CD cord-005453-4057qib7 2501 9 ± ± CD cord-005453-4057qib7 2501 10 1.7 1.7 CD cord-005453-4057qib7 2501 11 / / SYM cord-005453-4057qib7 2501 12 kg kg NN cord-005453-4057qib7 2501 13 . . . cord-005453-4057qib7 2502 1 Engraftment Engraftment NNP cord-005453-4057qib7 2502 2 was be VBD cord-005453-4057qib7 2502 3 achieved achieve VBN cord-005453-4057qib7 2502 4 in in IN cord-005453-4057qib7 2502 5 80 80 CD cord-005453-4057qib7 2502 6 % % NN cord-005453-4057qib7 2502 7 of of IN cord-005453-4057qib7 2502 8 patients patient NNS cord-005453-4057qib7 2502 9 . . . cord-005453-4057qib7 2503 1 The the DT cord-005453-4057qib7 2503 2 transplant transplant NN cord-005453-4057qib7 2503 3 related relate VBN cord-005453-4057qib7 2503 4 mortality mortality NN cord-005453-4057qib7 2503 5 was be VBD cord-005453-4057qib7 2503 6 19.5 19.5 CD cord-005453-4057qib7 2503 7 % % NN cord-005453-4057qib7 2503 8 and and CC cord-005453-4057qib7 2503 9 overall overall JJ cord-005453-4057qib7 2503 10 survival survival NN cord-005453-4057qib7 2503 11 was be VBD cord-005453-4057qib7 2503 12 72 72 CD cord-005453-4057qib7 2503 13 % % NN cord-005453-4057qib7 2503 14 ( ( -LRB- cord-005453-4057qib7 2503 15 follow follow VB cord-005453-4057qib7 2503 16 up up RB cord-005453-4057qib7 2503 17 : : : cord-005453-4057qib7 2503 18 104 104 CD cord-005453-4057qib7 2503 19 months month NNS cord-005453-4057qib7 2503 20 ) ) -RRB- cord-005453-4057qib7 2503 21 . . . cord-005453-4057qib7 2504 1 Since since IN cord-005453-4057qib7 2504 2 January January NNP cord-005453-4057qib7 2504 3 2016 2016 CD cord-005453-4057qib7 2504 4 till till IN cord-005453-4057qib7 2504 5 March March NNP cord-005453-4057qib7 2504 6 2018 2018 CD cord-005453-4057qib7 2504 7 we -PRON- PRP cord-005453-4057qib7 2504 8 have have VBP cord-005453-4057qib7 2504 9 performed perform VBN cord-005453-4057qib7 2504 10 n=18 n=18 JJ cord-005453-4057qib7 2504 11 autologous autologous JJ cord-005453-4057qib7 2504 12 transplants transplant NNS cord-005453-4057qib7 2504 13 of of IN cord-005453-4057qib7 2504 14 which which WDT cord-005453-4057qib7 2504 15 n=17 n=17 NNP cord-005453-4057qib7 2504 16 were be VBD cord-005453-4057qib7 2504 17 males male NNS cord-005453-4057qib7 2504 18 . . . cord-005453-4057qib7 2505 1 Fifteen fifteen CD cord-005453-4057qib7 2505 2 transplants transplant NNS cord-005453-4057qib7 2505 3 were be VBD cord-005453-4057qib7 2505 4 performed perform VBN cord-005453-4057qib7 2505 5 for for IN cord-005453-4057qib7 2505 6 lymphomas lymphoma NNS cord-005453-4057qib7 2505 7 ( ( -LRB- cord-005453-4057qib7 2505 8 NHL:8 nhl:8 XX cord-005453-4057qib7 2505 9 , , , cord-005453-4057qib7 2505 10 HD:7 hd:7 LS cord-005453-4057qib7 2505 11 ) ) -RRB- cord-005453-4057qib7 2505 12 and and CC cord-005453-4057qib7 2505 13 n=3 n=3 NN cord-005453-4057qib7 2505 14 for for IN cord-005453-4057qib7 2505 15 multiple multiple JJ cord-005453-4057qib7 2505 16 myeloma myeloma NN cord-005453-4057qib7 2505 17 . . . cord-005453-4057qib7 2506 1 Median median JJ cord-005453-4057qib7 2506 2 age age NN cord-005453-4057qib7 2506 3 was be VBD cord-005453-4057qib7 2506 4 24±15 24±15 NNP cord-005453-4057qib7 2506 5 ( ( -LRB- cord-005453-4057qib7 2506 6 20 20 CD cord-005453-4057qib7 2506 7 -64 -64 NN cord-005453-4057qib7 2506 8 years year NNS cord-005453-4057qib7 2506 9 ) ) -RRB- cord-005453-4057qib7 2506 10 . . . cord-005453-4057qib7 2507 1 The the DT cord-005453-4057qib7 2507 2 mean mean JJ cord-005453-4057qib7 2507 3 mononuclear mononuclear JJ cord-005453-4057qib7 2507 4 cell cell NN cord-005453-4057qib7 2507 5 count count NN cord-005453-4057qib7 2507 6 was be VBD cord-005453-4057qib7 2507 7 5.8 5.8 CD cord-005453-4057qib7 2507 8 x x SYM cord-005453-4057qib7 2507 9 10 10 CD cord-005453-4057qib7 2507 10 8 8 CD cord-005453-4057qib7 2507 11 /kg /kg . cord-005453-4057qib7 2507 12 and and CC cord-005453-4057qib7 2507 13 the the DT cord-005453-4057qib7 2507 14 mean mean JJ cord-005453-4057qib7 2507 15 CD34 CD34 NNP cord-005453-4057qib7 2507 16 count count NN cord-005453-4057qib7 2507 17 was be VBD cord-005453-4057qib7 2507 18 3.7 3.7 CD cord-005453-4057qib7 2507 19 x x SYM cord-005453-4057qib7 2507 20 10 10 CD cord-005453-4057qib7 2507 21 6 6 CD cord-005453-4057qib7 2507 22 /kg /kg . cord-005453-4057qib7 2507 23 . . . cord-005453-4057qib7 2508 1 Engraftment Engraftment NNP cord-005453-4057qib7 2508 2 was be VBD cord-005453-4057qib7 2508 3 achieved achieve VBN cord-005453-4057qib7 2508 4 in in IN cord-005453-4057qib7 2508 5 all all DT cord-005453-4057qib7 2508 6 patients patient NNS cord-005453-4057qib7 2508 7 . . . cord-005453-4057qib7 2509 1 The the DT cord-005453-4057qib7 2509 2 transplant transplant NN cord-005453-4057qib7 2509 3 related relate VBN cord-005453-4057qib7 2509 4 mortality mortality NN cord-005453-4057qib7 2509 5 was be VBD cord-005453-4057qib7 2509 6 0 0 CD cord-005453-4057qib7 2509 7 % % NN cord-005453-4057qib7 2509 8 and and CC cord-005453-4057qib7 2509 9 the the DT cord-005453-4057qib7 2509 10 overall overall JJ cord-005453-4057qib7 2509 11 survival survival NN cord-005453-4057qib7 2509 12 was be VBD cord-005453-4057qib7 2509 13 83 83 CD cord-005453-4057qib7 2509 14 % % NN cord-005453-4057qib7 2509 15 ( ( -LRB- cord-005453-4057qib7 2509 16 follow follow VB cord-005453-4057qib7 2509 17 up up RB cord-005453-4057qib7 2509 18 22 22 CD cord-005453-4057qib7 2509 19 months month NNS cord-005453-4057qib7 2509 20 ) ) -RRB- cord-005453-4057qib7 2509 21 . . . cord-005453-4057qib7 2510 1 Conclusions conclusion NNS cord-005453-4057qib7 2510 2 : : : cord-005453-4057qib7 2511 1 We -PRON- PRP cord-005453-4057qib7 2511 2 were be VBD cord-005453-4057qib7 2511 3 able able JJ cord-005453-4057qib7 2511 4 to to TO cord-005453-4057qib7 2511 5 reduce reduce VB cord-005453-4057qib7 2511 6 the the DT cord-005453-4057qib7 2511 7 autologous autologous JJ cord-005453-4057qib7 2511 8 transplant transplant NN cord-005453-4057qib7 2511 9 related relate VBN cord-005453-4057qib7 2511 10 mortality mortality NN cord-005453-4057qib7 2511 11 to to IN cord-005453-4057qib7 2511 12 0 0 CD cord-005453-4057qib7 2511 13 % % NN cord-005453-4057qib7 2511 14 by by IN cord-005453-4057qib7 2511 15 decreasing decrease VBG cord-005453-4057qib7 2511 16 dosages dosage NNS cord-005453-4057qib7 2511 17 of of IN cord-005453-4057qib7 2511 18 conditioning conditioning NN cord-005453-4057qib7 2511 19 chemotherapy chemotherapy NN cord-005453-4057qib7 2511 20 and and CC cord-005453-4057qib7 2511 21 changing change VBG cord-005453-4057qib7 2511 22 the the DT cord-005453-4057qib7 2511 23 mobilization mobilization NN cord-005453-4057qib7 2511 24 protocol protocol NN cord-005453-4057qib7 2511 25 . . . cord-005453-4057qib7 2512 1 Long long RB cord-005453-4057qib7 2512 2 follow follow NN cord-005453-4057qib7 2512 3 - - HYPH cord-005453-4057qib7 2512 4 up up NN cord-005453-4057qib7 2512 5 is be VBZ cord-005453-4057qib7 2512 6 needed need VBN cord-005453-4057qib7 2512 7 to to TO cord-005453-4057qib7 2512 8 determine determine VB cord-005453-4057qib7 2512 9 late late JJ cord-005453-4057qib7 2512 10 mortality mortality NN cord-005453-4057qib7 2512 11 and and CC cord-005453-4057qib7 2512 12 late late JJ cord-005453-4057qib7 2512 13 relapse relapse NN cord-005453-4057qib7 2512 14 in in IN cord-005453-4057qib7 2512 15 comparison comparison NN cord-005453-4057qib7 2512 16 to to IN cord-005453-4057qib7 2512 17 standard standard JJ cord-005453-4057qib7 2512 18 chemotherapy chemotherapy NN cord-005453-4057qib7 2512 19 dosages dosage NNS cord-005453-4057qib7 2512 20 Disclosure Disclosure NNP cord-005453-4057qib7 2512 21 : : : cord-005453-4057qib7 2512 22 Nothing nothing NN cord-005453-4057qib7 2512 23 to to TO cord-005453-4057qib7 2512 24 declare declare VB cord-005453-4057qib7 2512 25 Risk risk NN cord-005453-4057qib7 2512 26 and and CC cord-005453-4057qib7 2512 27 benefit benefit NN cord-005453-4057qib7 2512 28 of of IN cord-005453-4057qib7 2512 29 thiotepa thiotepa JJ cord-005453-4057qib7 2512 30 based base VBN cord-005453-4057qib7 2512 31 conditioning conditioning NN cord-005453-4057qib7 2512 32 followed follow VBN cord-005453-4057qib7 2512 33 by by IN cord-005453-4057qib7 2512 34 autologous autologous JJ cord-005453-4057qib7 2512 35 stem stem NN cord-005453-4057qib7 2512 36 cell cell NN cord-005453-4057qib7 2512 37 transplantation transplantation NN cord-005453-4057qib7 2512 38 in in IN cord-005453-4057qib7 2512 39 high high JJ cord-005453-4057qib7 2512 40 risk risk NN cord-005453-4057qib7 2512 41 lymphomas lymphoma NNS cord-005453-4057qib7 2512 42 36 36 CD cord-005453-4057qib7 2512 43 years year NNS cord-005453-4057qib7 2512 44 ( ( -LRB- cord-005453-4057qib7 2512 45 16 16 CD cord-005453-4057qib7 2512 46 - - SYM cord-005453-4057qib7 2512 47 62 62 CD cord-005453-4057qib7 2512 48 ) ) -RRB- cord-005453-4057qib7 2512 49 . . . cord-005453-4057qib7 2513 1 Stage stage NN cord-005453-4057qib7 2514 1 ( ( -LRB- cord-005453-4057qib7 2514 2 Ann Ann NNP cord-005453-4057qib7 2514 3 - - HYPH cord-005453-4057qib7 2514 4 Arbor Arbor NNP cord-005453-4057qib7 2514 5 ) ) -RRB- cord-005453-4057qib7 2515 1 at at IN cord-005453-4057qib7 2515 2 diagnosis diagnosis NN cord-005453-4057qib7 2515 3 of of IN cord-005453-4057qib7 2515 4 HD HD NNP cord-005453-4057qib7 2515 5 / / SYM cord-005453-4057qib7 2515 6 DLBCL DLBCL NNP cord-005453-4057qib7 2515 7 / / SYM cord-005453-4057qib7 2515 8 PCNSL PCNSL NNP cord-005453-4057qib7 2515 9 : : : cord-005453-4057qib7 2515 10 stage stage NN cord-005453-4057qib7 2515 11 IE IE NNP cord-005453-4057qib7 2515 12 n=0/ n=0/ NNP cord-005453-4057qib7 2515 13 0/10 0/10 NN cord-005453-4057qib7 2515 14 ( ( -LRB- cord-005453-4057qib7 2515 15 0/0/91 0/0/91 CD cord-005453-4057qib7 2515 16 % % NN cord-005453-4057qib7 2515 17 ) ) -RRB- cord-005453-4057qib7 2515 18 , , , cord-005453-4057qib7 2515 19 stage stage NN cord-005453-4057qib7 2515 20 II II NNP cord-005453-4057qib7 2515 21 n=7/2/0 n=7/2/0 NNP cord-005453-4057qib7 2515 22 ( ( -LRB- cord-005453-4057qib7 2515 23 47/18/0 47/18/0 CD cord-005453-4057qib7 2515 24 % % NN cord-005453-4057qib7 2515 25 ) ) -RRB- cord-005453-4057qib7 2515 26 , , . cord-005453-4057qib7 2516 1 stage stage NN cord-005453-4057qib7 2516 2 III III NNP cord-005453-4057qib7 2516 3 n=2/ n=2/ JJ cord-005453-4057qib7 2516 4 0/1 0/1 CD cord-005453-4057qib7 2516 5 ( ( -LRB- cord-005453-4057qib7 2516 6 13/0/9 13/0/9 CD cord-005453-4057qib7 2516 7 % % NN cord-005453-4057qib7 2516 8 ) ) -RRB- cord-005453-4057qib7 2516 9 , , . cord-005453-4057qib7 2517 1 stage stage NN cord-005453-4057qib7 2517 2 IV IV NNP cord-005453-4057qib7 2517 3 n=6/9/0 n=6/9/0 NNPS cord-005453-4057qib7 2517 4 ( ( -LRB- cord-005453-4057qib7 2517 5 40/82/0 40/82/0 CD cord-005453-4057qib7 2517 6 % % NN cord-005453-4057qib7 2517 7 ) ) -RRB- cord-005453-4057qib7 2517 8 . . . cord-005453-4057qib7 2518 1 Median median JJ cord-005453-4057qib7 2518 2 time time NN cord-005453-4057qib7 2518 3 from from IN cord-005453-4057qib7 2518 4 diagnosis diagnosis NN cord-005453-4057qib7 2518 5 to to IN cord-005453-4057qib7 2518 6 ASCT ASCT NNP cord-005453-4057qib7 2518 7 HD HD NNP cord-005453-4057qib7 2518 8 / / SYM cord-005453-4057qib7 2518 9 DLBCL DLBCL NNP cord-005453-4057qib7 2518 10 / / SYM cord-005453-4057qib7 2518 11 PCNSL PCNSL NNP cord-005453-4057qib7 2518 12 : : : cord-005453-4057qib7 2519 1 25/11/ 25/11/ CD cord-005453-4057qib7 2519 2 6 6 CD cord-005453-4057qib7 2519 3 month month NN cord-005453-4057qib7 2519 4 ( ( -LRB- cord-005453-4057qib7 2519 5 4 4 CD cord-005453-4057qib7 2519 6 - - SYM cord-005453-4057qib7 2519 7 72 72 CD cord-005453-4057qib7 2519 8 ) ) -RRB- cord-005453-4057qib7 2519 9 . . . cord-005453-4057qib7 2520 1 Induction induction NN cord-005453-4057qib7 2520 2 treatment treatment NN cord-005453-4057qib7 2520 3 in in IN cord-005453-4057qib7 2520 4 HD hd NN cord-005453-4057qib7 2520 5 patients patient NNS cord-005453-4057qib7 2520 6 was be VBD cord-005453-4057qib7 2520 7 ABVD ABVD NNP cord-005453-4057qib7 2520 8 , , , cord-005453-4057qib7 2520 9 in in IN cord-005453-4057qib7 2520 10 most most JJS cord-005453-4057qib7 2520 11 DLBCL DLBCL NNP cord-005453-4057qib7 2520 12 patients patient NNS cord-005453-4057qib7 2520 13 R r NN cord-005453-4057qib7 2520 14 - - HYPH cord-005453-4057qib7 2520 15 CHOP chop NN cord-005453-4057qib7 2520 16 and and CC cord-005453-4057qib7 2520 17 in in IN cord-005453-4057qib7 2520 18 PCNSL PCNSL NNP cord-005453-4057qib7 2520 19 patients patient NNS cord-005453-4057qib7 2520 20 high high JJ cord-005453-4057qib7 2520 21 dose dose NN cord-005453-4057qib7 2520 22 methotrexate methotrexate NNP cord-005453-4057qib7 2520 23 and and CC cord-005453-4057qib7 2520 24 cytosin cytosin NNP cord-005453-4057qib7 2520 25 arabinoside arabinoside NNP cord-005453-4057qib7 2520 26 . . . cord-005453-4057qib7 2521 1 Tumor tumor NN cord-005453-4057qib7 2521 2 status status NN cord-005453-4057qib7 2521 3 at at IN cord-005453-4057qib7 2521 4 ASCT ASCT NNP cord-005453-4057qib7 2521 5 HD HD NNP cord-005453-4057qib7 2521 6 / / SYM cord-005453-4057qib7 2521 7 DLBCL DLBCL NNP cord-005453-4057qib7 2521 8 / / SYM cord-005453-4057qib7 2521 9 PCNSL PCNSL NNP cord-005453-4057qib7 2521 10 : : : cord-005453-4057qib7 2521 11 complete complete JJ cord-005453-4057qib7 2521 12 metabolic metabolic JJ cord-005453-4057qib7 2521 13 remission remission NN cord-005453-4057qib7 2522 1 ( ( -LRB- cord-005453-4057qib7 2522 2 CMR CMR NNP cord-005453-4057qib7 2522 3 ) ) -RRB- cord-005453-4057qib7 2522 4 n=4/1/11 n=4/1/11 VBZ cord-005453-4057qib7 2522 5 ( ( -LRB- cord-005453-4057qib7 2522 6 27/9/91 27/9/91 CD cord-005453-4057qib7 2522 7 % % NN cord-005453-4057qib7 2522 8 ) ) -RRB- cord-005453-4057qib7 2523 1 and and CC cord-005453-4057qib7 2523 2 from from IN cord-005453-4057qib7 2523 3 PCNSL PCNSL NNP cord-005453-4057qib7 2523 4 patient patient NNP cord-005453-4057qib7 2523 5 's 's POS cord-005453-4057qib7 2523 6 n=8 n=8 NN cord-005453-4057qib7 2523 7 ( ( -LRB- cord-005453-4057qib7 2523 8 73 73 CD cord-005453-4057qib7 2523 9 % % NN cord-005453-4057qib7 2523 10 ) ) -RRB- cord-005453-4057qib7 2523 11 were be VBD cord-005453-4057qib7 2523 12 in in IN cord-005453-4057qib7 2523 13 first first JJ cord-005453-4057qib7 2523 14 complete complete JJ cord-005453-4057qib7 2523 15 remission remission NN cord-005453-4057qib7 2523 16 ( ( -LRB- cord-005453-4057qib7 2523 17 CR1 CR1 NNP cord-005453-4057qib7 2523 18 ) ) -RRB- cord-005453-4057qib7 2523 19 . . . cord-005453-4057qib7 2524 1 Type type NN cord-005453-4057qib7 2524 2 of of IN cord-005453-4057qib7 2524 3 stem stem NN cord-005453-4057qib7 2524 4 cell cell NN cord-005453-4057qib7 2524 5 graft graft NN cord-005453-4057qib7 2524 6 was be VBD cord-005453-4057qib7 2524 7 periferial periferial JJ cord-005453-4057qib7 2524 8 blood blood NN cord-005453-4057qib7 2524 9 stem stem NN cord-005453-4057qib7 2524 10 cell cell NN cord-005453-4057qib7 2524 11 in in IN cord-005453-4057qib7 2524 12 all all DT cord-005453-4057qib7 2524 13 case case NN cord-005453-4057qib7 2524 14 . . . cord-005453-4057qib7 2525 1 Conditioning conditioning NN cord-005453-4057qib7 2525 2 : : : cord-005453-4057qib7 2525 3 thiotepa thiotepa NNP cord-005453-4057qib7 2525 4 ( ( -LRB- cord-005453-4057qib7 2525 5 250mg/ 250mg/ CD cord-005453-4057qib7 2525 6 m2 m2 NNP cord-005453-4057qib7 2525 7 on on IN cord-005453-4057qib7 2525 8 days day NNS cord-005453-4057qib7 2525 9 -9 -9 ADD cord-005453-4057qib7 2525 10 to to IN cord-005453-4057qib7 2525 11 -7 -7 NNP cord-005453-4057qib7 2525 12 , , , cord-005453-4057qib7 2525 13 busulphan busulphan NNP cord-005453-4057qib7 2525 14 3,2mg 3,2mg CD cord-005453-4057qib7 2525 15 / / SYM cord-005453-4057qib7 2525 16 kg kg NNS cord-005453-4057qib7 2525 17 on on IN cord-005453-4057qib7 2525 18 days day NNS cord-005453-4057qib7 2525 19 -6 -6 JJ cord-005453-4057qib7 2525 20 to to IN cord-005453-4057qib7 2525 21 -4 -4 CD cord-005453-4057qib7 2525 22 and and CC cord-005453-4057qib7 2525 23 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 2525 24 60mg 60mg NN cord-005453-4057qib7 2525 25 / / SYM cord-005453-4057qib7 2525 26 kg kg NNS cord-005453-4057qib7 2525 27 on on IN cord-005453-4057qib7 2525 28 days day NNS cord-005453-4057qib7 2525 29 -3 -3 NNP cord-005453-4057qib7 2525 30 to to IN cord-005453-4057qib7 2525 31 -2 -2 NNP cord-005453-4057qib7 2525 32 plus plus CC cord-005453-4057qib7 2525 33 rituximab rituximab NNP cord-005453-4057qib7 2525 34 500mg 500mg NNP cord-005453-4057qib7 2525 35 / / SYM cord-005453-4057qib7 2525 36 m2 m2 NNP cord-005453-4057qib7 2525 37 on on IN cord-005453-4057qib7 2525 38 day day NN cord-005453-4057qib7 2525 39 -10 -10 NN cord-005453-4057qib7 2525 40 in in IN cord-005453-4057qib7 2525 41 DLBCL DLBCL NNP cord-005453-4057qib7 2525 42 and and CC cord-005453-4057qib7 2525 43 PCNSL PCNSL NNP cord-005453-4057qib7 2525 44 . . . cord-005453-4057qib7 2526 1 Median median JJ cord-005453-4057qib7 2526 2 follow follow VBP cord-005453-4057qib7 2526 3 up up RP cord-005453-4057qib7 2526 4 from from IN cord-005453-4057qib7 2526 5 ASCT ASCT NNP cord-005453-4057qib7 2526 6 711 711 CD cord-005453-4057qib7 2526 7 days day NNS cord-005453-4057qib7 2526 8 . . . cord-005453-4057qib7 2527 1 Tumor tumor NN cord-005453-4057qib7 2527 2 stage stage NN cord-005453-4057qib7 2527 3 at at IN cord-005453-4057qib7 2527 4 ASCT ASCT NNP cord-005453-4057qib7 2527 5 was be VBD cord-005453-4057qib7 2527 6 defined define VBN cord-005453-4057qib7 2527 7 with with IN cord-005453-4057qib7 2527 8 computer computer NN cord-005453-4057qib7 2527 9 tomography tomography NN cord-005453-4057qib7 2527 10 with with IN cord-005453-4057qib7 2527 11 positron positron NN cord-005453-4057qib7 2527 12 emission emission NN cord-005453-4057qib7 2527 13 tomography tomography NN cord-005453-4057qib7 2527 14 ( ( -LRB- cord-005453-4057qib7 2527 15 PET PET NNP cord-005453-4057qib7 2527 16 - - HYPH cord-005453-4057qib7 2527 17 CT CT NNP cord-005453-4057qib7 2527 18 ) ) -RRB- cord-005453-4057qib7 2527 19 . . . cord-005453-4057qib7 2528 1 Results result NNS cord-005453-4057qib7 2528 2 : : : cord-005453-4057qib7 2529 1 Median median JJ cord-005453-4057qib7 2529 2 time time NN cord-005453-4057qib7 2529 3 of of IN cord-005453-4057qib7 2529 4 engraftment engraftment NN cord-005453-4057qib7 2529 5 was be VBD cord-005453-4057qib7 2529 6 10 10 CD cord-005453-4057qib7 2529 7 days day NNS cord-005453-4057qib7 2529 8 ( ( -LRB- cord-005453-4057qib7 2529 9 9 9 CD cord-005453-4057qib7 2529 10 - - SYM cord-005453-4057qib7 2529 11 14 14 CD cord-005453-4057qib7 2529 12 ) ) -RRB- cord-005453-4057qib7 2529 13 . . . cord-005453-4057qib7 2530 1 Thiotepa Thiotepa NNP cord-005453-4057qib7 2530 2 caused cause VBD cord-005453-4057qib7 2530 3 toxicoderma toxicoderma NNS cord-005453-4057qib7 2530 4 appeared appear VBD cord-005453-4057qib7 2530 5 at at IN cord-005453-4057qib7 2530 6 9 9 CD cord-005453-4057qib7 2530 7 ( ( -LRB- cord-005453-4057qib7 2530 8 24 24 CD cord-005453-4057qib7 2530 9 % % NN cord-005453-4057qib7 2530 10 ) ) -RRB- cord-005453-4057qib7 2530 11 patients patient NNS cord-005453-4057qib7 2530 12 . . . cord-005453-4057qib7 2531 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 2531 2 ( ( -LRB- cord-005453-4057qib7 2531 3 CMV CMV NNP cord-005453-4057qib7 2531 4 ) ) -RRB- cord-005453-4057qib7 2531 5 reactivation reactivation NN cord-005453-4057qib7 2531 6 was be VBD cord-005453-4057qib7 2531 7 seen see VBN cord-005453-4057qib7 2531 8 in in IN cord-005453-4057qib7 2531 9 3 3 CD cord-005453-4057qib7 2531 10 ( ( -LRB- cord-005453-4057qib7 2531 11 8 8 CD cord-005453-4057qib7 2531 12 % % NN cord-005453-4057qib7 2531 13 ) ) -RRB- cord-005453-4057qib7 2531 14 cases case NNS cord-005453-4057qib7 2531 15 with with IN cord-005453-4057qib7 2531 16 low low JJ cord-005453-4057qib7 2531 17 DNA dna NN cord-005453-4057qib7 2531 18 content content NN cord-005453-4057qib7 2531 19 ( ( -LRB- cord-005453-4057qib7 2531 20 284,454,5500 284,454,5500 CD cord-005453-4057qib7 2531 21 copies copy NNS cord-005453-4057qib7 2531 22 / / SYM cord-005453-4057qib7 2531 23 ml ml NN cord-005453-4057qib7 2531 24 ) ) -RRB- cord-005453-4057qib7 2531 25 and and CC cord-005453-4057qib7 2531 26 responded respond VBD cord-005453-4057qib7 2531 27 completely completely RB cord-005453-4057qib7 2531 28 to to IN cord-005453-4057qib7 2531 29 oral oral JJ cord-005453-4057qib7 2531 30 valgancyclovir valgancyclovir NNS cord-005453-4057qib7 2531 31 therapy therapy NN cord-005453-4057qib7 2531 32 . . . cord-005453-4057qib7 2532 1 Transplantation transplantation NN cord-005453-4057qib7 2532 2 related relate VBN cord-005453-4057qib7 2532 3 mortality mortality NN cord-005453-4057qib7 2533 1 HD HD NNP cord-005453-4057qib7 2533 2 / / SYM cord-005453-4057qib7 2533 3 DLBCL/ DLBCL/ NNP cord-005453-4057qib7 2534 1 PCNSL PCNSL NNP cord-005453-4057qib7 2534 2 n= n= NNP cord-005453-4057qib7 2535 1 2/3/1 2/3/1 LS cord-005453-4057qib7 2535 2 ( ( -LRB- cord-005453-4057qib7 2535 3 9/27/13 9/27/13 CD cord-005453-4057qib7 2535 4 % % NN cord-005453-4057qib7 2535 5 ) ) -RRB- cord-005453-4057qib7 2535 6 , , , cord-005453-4057qib7 2535 7 in in IN cord-005453-4057qib7 2535 8 4 4 CD cord-005453-4057qib7 2535 9 cases case NNS cord-005453-4057qib7 2535 10 bacterial bacterial JJ cord-005453-4057qib7 2535 11 sepsis sepsis NN cord-005453-4057qib7 2535 12 and and CC cord-005453-4057qib7 2535 13 one one CD cord-005453-4057qib7 2535 14 systemic systemic JJ cord-005453-4057qib7 2535 15 mycoses mycose NNS cord-005453-4057qib7 2535 16 and and CC cord-005453-4057qib7 2535 17 one one CD cord-005453-4057qib7 2535 18 pulmonary pulmonary JJ cord-005453-4057qib7 2535 19 fibrosis fibrosis NN cord-005453-4057qib7 2535 20 . . . cord-005453-4057qib7 2536 1 Incidence incidence NN cord-005453-4057qib7 2536 2 of of IN cord-005453-4057qib7 2536 3 long long RB cord-005453-4057qib7 2536 4 - - HYPH cord-005453-4057qib7 2536 5 lasting last VBG cord-005453-4057qib7 2536 6 grade grade NN cord-005453-4057qib7 2536 7 III III NNP cord-005453-4057qib7 2536 8 - - HYPH cord-005453-4057qib7 2536 9 IV IV NNP cord-005453-4057qib7 2536 10 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2536 11 and and CC cord-005453-4057qib7 2536 12 anaemia anaemia NN cord-005453-4057qib7 2536 13 : : : cord-005453-4057qib7 2536 14 n=15 n=15 NNP cord-005453-4057qib7 2536 15 ( ( -LRB- cord-005453-4057qib7 2536 16 40,5 40,5 CD cord-005453-4057qib7 2536 17 % % NN cord-005453-4057qib7 2536 18 ) ) -RRB- cord-005453-4057qib7 2536 19 and and CC cord-005453-4057qib7 2536 20 n=3 n=3 NN cord-005453-4057qib7 2536 21 ( ( -LRB- cord-005453-4057qib7 2536 22 8 8 CD cord-005453-4057qib7 2536 23 % % NN cord-005453-4057qib7 2536 24 ) ) -RRB- cord-005453-4057qib7 2536 25 , , , cord-005453-4057qib7 2536 26 median median JJ cord-005453-4057qib7 2536 27 time time NN cord-005453-4057qib7 2536 28 of of IN cord-005453-4057qib7 2536 29 duration duration NN cord-005453-4057qib7 2536 30 from from IN cord-005453-4057qib7 2536 31 transplantation transplantation NN cord-005453-4057qib7 2536 32 71 71 CD cord-005453-4057qib7 2536 33 days day NNS cord-005453-4057qib7 2536 34 ( ( -LRB- cord-005453-4057qib7 2536 35 31 31 CD cord-005453-4057qib7 2536 36 - - SYM cord-005453-4057qib7 2536 37 720 720 CD cord-005453-4057qib7 2536 38 ) ) -RRB- cord-005453-4057qib7 2536 39 and and CC cord-005453-4057qib7 2536 40 35 35 CD cord-005453-4057qib7 2536 41 days day NNS cord-005453-4057qib7 2537 1 ( ( -LRB- cord-005453-4057qib7 2537 2 Background background NN cord-005453-4057qib7 2537 3 : : : cord-005453-4057qib7 2538 1 This this DT cord-005453-4057qib7 2538 2 study study NN cord-005453-4057qib7 2538 3 evaluated evaluate VBD cord-005453-4057qib7 2538 4 the the DT cord-005453-4057qib7 2538 5 efficacy efficacy NN cord-005453-4057qib7 2538 6 and and CC cord-005453-4057qib7 2538 7 toxicity toxicity NN cord-005453-4057qib7 2538 8 of of IN cord-005453-4057qib7 2538 9 intravenous intravenous JJ cord-005453-4057qib7 2538 10 busulfan busulfan NN cord-005453-4057qib7 2538 11 and and CC cord-005453-4057qib7 2538 12 thiotepa thiotepa NNP cord-005453-4057qib7 2538 13 as as IN cord-005453-4057qib7 2538 14 a a DT cord-005453-4057qib7 2538 15 conditioning conditioning NN cord-005453-4057qib7 2538 16 regimen regimen NN cord-005453-4057qib7 2538 17 for for IN cord-005453-4057qib7 2538 18 autologous autologous JJ cord-005453-4057qib7 2538 19 stem stem NN cord-005453-4057qib7 2538 20 cell cell NN cord-005453-4057qib7 2538 21 transplantation transplantation NN cord-005453-4057qib7 2538 22 ( ( -LRB- cord-005453-4057qib7 2538 23 ASCT ASCT NNP cord-005453-4057qib7 2538 24 ) ) -RRB- cord-005453-4057qib7 2538 25 in in IN cord-005453-4057qib7 2538 26 patients patient NNS cord-005453-4057qib7 2538 27 with with IN cord-005453-4057qib7 2538 28 multiple multiple JJ cord-005453-4057qib7 2538 29 myeloma myeloma NN cord-005453-4057qib7 2538 30 ( ( -LRB- cord-005453-4057qib7 2538 31 MM MM NNP cord-005453-4057qib7 2538 32 ) ) -RRB- cord-005453-4057qib7 2538 33 . . . cord-005453-4057qib7 2539 1 Methods method NNS cord-005453-4057qib7 2539 2 : : : cord-005453-4057qib7 2539 3 We -PRON- PRP cord-005453-4057qib7 2539 4 retrospectively retrospectively RB cord-005453-4057qib7 2539 5 analyzed analyze VBD cord-005453-4057qib7 2539 6 the the DT cord-005453-4057qib7 2539 7 data datum NNS cord-005453-4057qib7 2539 8 of of IN cord-005453-4057qib7 2539 9 68 68 CD cord-005453-4057qib7 2539 10 patients patient NNS cord-005453-4057qib7 2539 11 with with IN cord-005453-4057qib7 2539 12 MM MM NNP cord-005453-4057qib7 2539 13 who who WP cord-005453-4057qib7 2539 14 received receive VBD cord-005453-4057qib7 2539 15 the the DT cord-005453-4057qib7 2539 16 intravenous intravenous JJ cord-005453-4057qib7 2539 17 busulfan busulfan NN cord-005453-4057qib7 2539 18 and and CC cord-005453-4057qib7 2539 19 thiotepa thiotepa JJ cord-005453-4057qib7 2539 20 conditioning conditioning NN cord-005453-4057qib7 2539 21 for for IN cord-005453-4057qib7 2539 22 ASCT ASCT NNP cord-005453-4057qib7 2539 23 between between IN cord-005453-4057qib7 2539 24 November November NNP cord-005453-4057qib7 2539 25 2016 2016 CD cord-005453-4057qib7 2539 26 and and CC cord-005453-4057qib7 2539 27 April April NNP cord-005453-4057qib7 2539 28 2018 2018 CD cord-005453-4057qib7 2539 29 in in IN cord-005453-4057qib7 2539 30 Korea Korea NNP cord-005453-4057qib7 2539 31 . . . cord-005453-4057qib7 2540 1 Results result NNS cord-005453-4057qib7 2540 2 : : : cord-005453-4057qib7 2541 1 The the DT cord-005453-4057qib7 2541 2 median median JJ cord-005453-4057qib7 2541 3 time time NN cord-005453-4057qib7 2541 4 to to IN cord-005453-4057qib7 2541 5 transplant transplant NN cord-005453-4057qib7 2541 6 was be VBD cord-005453-4057qib7 2541 7 5.4 5.4 CD cord-005453-4057qib7 2541 8 months month NNS cord-005453-4057qib7 2541 9 , , , cord-005453-4057qib7 2541 10 and and CC cord-005453-4057qib7 2541 11 66 66 CD cord-005453-4057qib7 2541 12 patients patient NNS cord-005453-4057qib7 2541 13 ( ( -LRB- cord-005453-4057qib7 2541 14 97.1 97.1 CD cord-005453-4057qib7 2541 15 % % NN cord-005453-4057qib7 2541 16 ) ) -RRB- cord-005453-4057qib7 2541 17 underwent undergo VBD cord-005453-4057qib7 2541 18 ASCT ASCT NNP cord-005453-4057qib7 2541 19 within within IN cord-005453-4057qib7 2541 20 12 12 CD cord-005453-4057qib7 2541 21 months month NNS cord-005453-4057qib7 2541 22 of of IN cord-005453-4057qib7 2541 23 the the DT cord-005453-4057qib7 2541 24 diagnosis diagnosis NN cord-005453-4057qib7 2541 25 . . . cord-005453-4057qib7 2542 1 The the DT cord-005453-4057qib7 2542 2 overall overall JJ cord-005453-4057qib7 2542 3 response response NN cord-005453-4057qib7 2542 4 rate rate NN cord-005453-4057qib7 2542 5 after after IN cord-005453-4057qib7 2542 6 ASCT ASCT NNP cord-005453-4057qib7 2542 7 was be VBD cord-005453-4057qib7 2542 8 95.6 95.6 CD cord-005453-4057qib7 2542 9 % % NN cord-005453-4057qib7 2542 10 , , , cord-005453-4057qib7 2542 11 including include VBG cord-005453-4057qib7 2542 12 55.9 55.9 CD cord-005453-4057qib7 2542 13 % % NN cord-005453-4057qib7 2542 14 with with IN cord-005453-4057qib7 2542 15 complete complete JJ cord-005453-4057qib7 2542 16 response response NN cord-005453-4057qib7 2542 17 , , , cord-005453-4057qib7 2542 18 22.1 22.1 CD cord-005453-4057qib7 2542 19 % % NN cord-005453-4057qib7 2542 20 with with IN cord-005453-4057qib7 2542 21 very very RB cord-005453-4057qib7 2542 22 good good JJ cord-005453-4057qib7 2542 23 partial partial JJ cord-005453-4057qib7 2542 24 response response NN cord-005453-4057qib7 2542 25 , , , cord-005453-4057qib7 2542 26 and and CC cord-005453-4057qib7 2542 27 17.6 17.6 CD cord-005453-4057qib7 2542 28 % % NN cord-005453-4057qib7 2542 29 with with IN cord-005453-4057qib7 2542 30 partial partial JJ cord-005453-4057qib7 2542 31 response response NN cord-005453-4057qib7 2542 32 . . . cord-005453-4057qib7 2543 1 The the DT cord-005453-4057qib7 2543 2 most most RBS cord-005453-4057qib7 2543 3 common common JJ cord-005453-4057qib7 2543 4 severe severe JJ cord-005453-4057qib7 2543 5 non non JJ cord-005453-4057qib7 2543 6 - - JJ cord-005453-4057qib7 2543 7 hematologic hematologic JJ cord-005453-4057qib7 2543 8 toxicity toxicity NN cord-005453-4057qib7 2543 9 ( ( -LRB- cord-005453-4057qib7 2543 10 grade grade NN cord-005453-4057qib7 2543 11 3 3 CD cord-005453-4057qib7 2543 12 - - SYM cord-005453-4057qib7 2543 13 4 4 CD cord-005453-4057qib7 2543 14 ) ) -RRB- cord-005453-4057qib7 2543 15 was be VBD cord-005453-4057qib7 2543 16 infection infection NN cord-005453-4057qib7 2543 17 ( ( -LRB- cord-005453-4057qib7 2543 18 44.1 44.1 CD cord-005453-4057qib7 2543 19 % % NN cord-005453-4057qib7 2543 20 ) ) -RRB- cord-005453-4057qib7 2543 21 . . . cord-005453-4057qib7 2544 1 Three three CD cord-005453-4057qib7 2544 2 patients patient NNS cord-005453-4057qib7 2544 3 ( ( -LRB- cord-005453-4057qib7 2544 4 4.4 4.4 CD cord-005453-4057qib7 2544 5 % % NN cord-005453-4057qib7 2544 6 ) ) -RRB- cord-005453-4057qib7 2544 7 developed develop VBN cord-005453-4057qib7 2544 8 venous venous JJ cord-005453-4057qib7 2544 9 - - HYPH cord-005453-4057qib7 2544 10 occlusive occlusive JJ cord-005453-4057qib7 2544 11 disease disease NN cord-005453-4057qib7 2544 12 . . . cord-005453-4057qib7 2545 1 One one CD cord-005453-4057qib7 2545 2 patient patient NN cord-005453-4057qib7 2545 3 ( ( -LRB- cord-005453-4057qib7 2545 4 1.5 1.5 CD cord-005453-4057qib7 2545 5 % % NN cord-005453-4057qib7 2545 6 ) ) -RRB- cord-005453-4057qib7 2545 7 died die VBD cord-005453-4057qib7 2545 8 due due JJ cord-005453-4057qib7 2545 9 to to IN cord-005453-4057qib7 2545 10 severe severe JJ cord-005453-4057qib7 2545 11 pneumonia pneumonia NN cord-005453-4057qib7 2545 12 after after IN cord-005453-4057qib7 2545 13 ASCT ASCT NNP cord-005453-4057qib7 2545 14 . . . cord-005453-4057qib7 2546 1 After after IN cord-005453-4057qib7 2546 2 a a DT cord-005453-4057qib7 2546 3 median median JJ cord-005453-4057qib7 2546 4 follow follow NN cord-005453-4057qib7 2546 5 - - HYPH cord-005453-4057qib7 2546 6 up up NN cord-005453-4057qib7 2546 7 of of IN cord-005453-4057qib7 2546 8 13.0 13.0 CD cord-005453-4057qib7 2546 9 months month NNS cord-005453-4057qib7 2546 10 , , , cord-005453-4057qib7 2546 11 the the DT cord-005453-4057qib7 2546 12 median median JJ cord-005453-4057qib7 2546 13 progression progression NN cord-005453-4057qib7 2546 14 - - HYPH cord-005453-4057qib7 2546 15 free free JJ cord-005453-4057qib7 2546 16 survival survival NN cord-005453-4057qib7 2546 17 ( ( -LRB- cord-005453-4057qib7 2546 18 PFS PFS NNP cord-005453-4057qib7 2546 19 ) ) -RRB- cord-005453-4057qib7 2546 20 and and CC cord-005453-4057qib7 2546 21 overall overall JJ cord-005453-4057qib7 2546 22 survival survival NN cord-005453-4057qib7 2546 23 ( ( -LRB- cord-005453-4057qib7 2546 24 OS OS NNP cord-005453-4057qib7 2546 25 ) ) -RRB- cord-005453-4057qib7 2546 26 were be VBD cord-005453-4057qib7 2546 27 not not RB cord-005453-4057qib7 2546 28 reached reach VBN cord-005453-4057qib7 2546 29 . . . cord-005453-4057qib7 2547 1 Conclusions conclusion NNS cord-005453-4057qib7 2547 2 : : : cord-005453-4057qib7 2548 1 In in IN cord-005453-4057qib7 2548 2 conclusion conclusion NN cord-005453-4057qib7 2548 3 , , , cord-005453-4057qib7 2548 4 a a DT cord-005453-4057qib7 2548 5 conditioning conditioning NN cord-005453-4057qib7 2548 6 regimen regimen NN cord-005453-4057qib7 2548 7 of of IN cord-005453-4057qib7 2548 8 intravenous intravenous JJ cord-005453-4057qib7 2548 9 busulfan busulfan NN cord-005453-4057qib7 2548 10 and and CC cord-005453-4057qib7 2548 11 thiotepa thiotepa NNP cord-005453-4057qib7 2548 12 was be VBD cord-005453-4057qib7 2548 13 effective effective JJ cord-005453-4057qib7 2548 14 and and CC cord-005453-4057qib7 2548 15 tolerable tolerable JJ cord-005453-4057qib7 2548 16 . . . cord-005453-4057qib7 2549 1 Clinical clinical JJ cord-005453-4057qib7 2549 2 Trial Trial NNP cord-005453-4057qib7 2549 3 Registry Registry NNP cord-005453-4057qib7 2549 4 : : : cord-005453-4057qib7 2550 1 Not not RB cord-005453-4057qib7 2550 2 applicable applicable JJ cord-005453-4057qib7 2550 3 Disclosure disclosure NN cord-005453-4057qib7 2550 4 : : : cord-005453-4057qib7 2550 5 The the DT cord-005453-4057qib7 2550 6 authors author NNS cord-005453-4057qib7 2550 7 have have VBP cord-005453-4057qib7 2550 8 declared declare VBN cord-005453-4057qib7 2550 9 no no DT cord-005453-4057qib7 2550 10 conflicts conflict NNS cord-005453-4057qib7 2550 11 of of IN cord-005453-4057qib7 2550 12 interest interest NN cord-005453-4057qib7 2550 13 . . . cord-005453-4057qib7 2551 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 2551 2 haploidentical haploidentical JJ cord-005453-4057qib7 2551 3 bone bone NN cord-005453-4057qib7 2551 4 marrow marrow NN cord-005453-4057qib7 2551 5 transplantation transplantation NN cord-005453-4057qib7 2551 6 with with IN cord-005453-4057qib7 2551 7 post post JJ cord-005453-4057qib7 2551 8 - - JJ cord-005453-4057qib7 2551 9 transplant transplant JJ cord-005453-4057qib7 2551 10 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 2551 11 in in IN cord-005453-4057qib7 2551 12 paediatric paediatric JJ cord-005453-4057qib7 2551 13 patients patient NNS cord-005453-4057qib7 2551 14 with with IN cord-005453-4057qib7 2551 15 haematological haematological JJ cord-005453-4057qib7 2551 16 malignancies malignancy NNS cord-005453-4057qib7 2552 1 Santanu Santanu NNP cord-005453-4057qib7 2552 2 Sen Sen NNP cord-005453-4057qib7 2552 3 1 1 CD cord-005453-4057qib7 2553 1 , , , cord-005453-4057qib7 2553 2 Sameer Sameer NNP cord-005453-4057qib7 2553 3 Tulpule Tulpule NNP cord-005453-4057qib7 2553 4 1 1 CD cord-005453-4057qib7 2553 5 Background Background NNP cord-005453-4057qib7 2553 6 : : : cord-005453-4057qib7 2553 7 Haploidentical Haploidentical NNP cord-005453-4057qib7 2553 8 transplants transplant NNS cord-005453-4057qib7 2553 9 have have VBP cord-005453-4057qib7 2553 10 been be VBN cord-005453-4057qib7 2553 11 shown show VBN cord-005453-4057qib7 2553 12 to to TO cord-005453-4057qib7 2553 13 be be VB cord-005453-4057qib7 2553 14 safe safe JJ cord-005453-4057qib7 2553 15 and and CC cord-005453-4057qib7 2553 16 effective effective JJ cord-005453-4057qib7 2553 17 in in IN cord-005453-4057qib7 2553 18 treating treat VBG cord-005453-4057qib7 2553 19 haematological haematological JJ cord-005453-4057qib7 2553 20 malignancies malignancy NNS cord-005453-4057qib7 2553 21 in in IN cord-005453-4057qib7 2553 22 the the DT cord-005453-4057qib7 2553 23 paediatric paediatric JJ cord-005453-4057qib7 2553 24 population population NN cord-005453-4057qib7 2553 25 . . . cord-005453-4057qib7 2554 1 We -PRON- PRP cord-005453-4057qib7 2554 2 have have VBP cord-005453-4057qib7 2554 3 previously previously RB cord-005453-4057qib7 2554 4 reported report VBN cord-005453-4057qib7 2554 5 on on IN cord-005453-4057qib7 2554 6 our -PRON- PRP$ cord-005453-4057qib7 2554 7 experience experience NN cord-005453-4057qib7 2554 8 of of IN cord-005453-4057qib7 2554 9 using use VBG cord-005453-4057qib7 2554 10 reduced reduce VBN cord-005453-4057qib7 2554 11 intensity intensity NN cord-005453-4057qib7 2554 12 conditioning conditioning NN cord-005453-4057qib7 2554 13 with with IN cord-005453-4057qib7 2554 14 post post NN cord-005453-4057qib7 2554 15 Transplant Transplant NNP cord-005453-4057qib7 2554 16 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 2554 17 in in IN cord-005453-4057qib7 2554 18 Haploidentical Haploidentical NNP cord-005453-4057qib7 2554 19 patients patient NNS cord-005453-4057qib7 2554 20 . . . cord-005453-4057qib7 2555 1 We -PRON- PRP cord-005453-4057qib7 2555 2 herein herein RB cord-005453-4057qib7 2555 3 report report VBP cord-005453-4057qib7 2555 4 our -PRON- PRP$ cord-005453-4057qib7 2555 5 experience experience NN cord-005453-4057qib7 2555 6 of of IN cord-005453-4057qib7 2555 7 using use VBG cord-005453-4057qib7 2555 8 a a DT cord-005453-4057qib7 2555 9 TBI TBI NNP cord-005453-4057qib7 2555 10 based base VBN cord-005453-4057qib7 2555 11 Myeloablative Myeloablative NNP cord-005453-4057qib7 2555 12 conditioning conditioning NN cord-005453-4057qib7 2555 13 to to TO cord-005453-4057qib7 2555 14 treat treat VB cord-005453-4057qib7 2555 15 our -PRON- PRP$ cord-005453-4057qib7 2555 16 first first JJ cord-005453-4057qib7 2555 17 8 8 CD cord-005453-4057qib7 2555 18 patients patient NNS cord-005453-4057qib7 2555 19 with with IN cord-005453-4057qib7 2555 20 haematological haematological JJ cord-005453-4057qib7 2555 21 malignancies malignancy NNS cord-005453-4057qib7 2555 22 . . . cord-005453-4057qib7 2556 1 Methods method NNS cord-005453-4057qib7 2556 2 : : : cord-005453-4057qib7 2556 3 8 8 CD cord-005453-4057qib7 2556 4 patients patient NNS cord-005453-4057qib7 2556 5 were be VBD cord-005453-4057qib7 2556 6 enrolled enrol VBN cord-005453-4057qib7 2556 7 in in IN cord-005453-4057qib7 2556 8 the the DT cord-005453-4057qib7 2556 9 study study NN cord-005453-4057qib7 2556 10 , , , cord-005453-4057qib7 2556 11 5 5 CD cord-005453-4057qib7 2556 12 with with IN cord-005453-4057qib7 2556 13 relapsed relapse VBN cord-005453-4057qib7 2556 14 Acute Acute NNP cord-005453-4057qib7 2556 15 Lymphoblastic Lymphoblastic NNP cord-005453-4057qib7 2556 16 Leukemia Leukemia NNP cord-005453-4057qib7 2556 17 ( ( -LRB- cord-005453-4057qib7 2556 18 ALL all DT cord-005453-4057qib7 2556 19 ) ) -RRB- cord-005453-4057qib7 2556 20 and and CC cord-005453-4057qib7 2556 21 3 3 CD cord-005453-4057qib7 2556 22 with with IN cord-005453-4057qib7 2556 23 relapsed relapse VBN cord-005453-4057qib7 2556 24 / / SYM cord-005453-4057qib7 2556 25 resistant resistant JJ cord-005453-4057qib7 2556 26 Acute Acute NNP cord-005453-4057qib7 2556 27 Myeloid Myeloid NNP cord-005453-4057qib7 2556 28 Leukemia Leukemia NNP cord-005453-4057qib7 2556 29 ( ( -LRB- cord-005453-4057qib7 2556 30 AML AML NNP cord-005453-4057qib7 2556 31 ) ) -RRB- cord-005453-4057qib7 2556 32 . . . cord-005453-4057qib7 2557 1 All all DT cord-005453-4057qib7 2557 2 AML AML NNP cord-005453-4057qib7 2557 3 patients patient NNS cord-005453-4057qib7 2557 4 had have VBD cord-005453-4057qib7 2557 5 genetic genetic JJ cord-005453-4057qib7 2557 6 markers marker NNS cord-005453-4057qib7 2557 7 of of IN cord-005453-4057qib7 2557 8 high high JJ cord-005453-4057qib7 2557 9 risk risk NN cord-005453-4057qib7 2557 10 disease disease NN cord-005453-4057qib7 2557 11 and and CC cord-005453-4057qib7 2557 12 all all PDT cord-005453-4057qib7 2557 13 ALL all DT cord-005453-4057qib7 2557 14 patients patient NNS cord-005453-4057qib7 2557 15 had have VBD cord-005453-4057qib7 2557 16 very very RB cord-005453-4057qib7 2557 17 early early JJ cord-005453-4057qib7 2557 18 relapses relapse NNS cord-005453-4057qib7 2557 19 ( ( -LRB- cord-005453-4057qib7 2557 20 either either CC cord-005453-4057qib7 2557 21 on on IN cord-005453-4057qib7 2557 22 therapy therapy NN cord-005453-4057qib7 2557 23 or or CC cord-005453-4057qib7 2557 24 within within IN cord-005453-4057qib7 2557 25 6 6 CD cord-005453-4057qib7 2557 26 months month NNS cord-005453-4057qib7 2557 27 of of IN cord-005453-4057qib7 2557 28 stopping stop VBG cord-005453-4057qib7 2557 29 therapy therapy NN cord-005453-4057qib7 2557 30 ) ) -RRB- cord-005453-4057qib7 2557 31 . . . cord-005453-4057qib7 2558 1 All all DT cord-005453-4057qib7 2558 2 patients patient NNS cord-005453-4057qib7 2558 3 were be VBD cord-005453-4057qib7 2558 4 conditioned condition VBN cord-005453-4057qib7 2558 5 with with IN cord-005453-4057qib7 2558 6 an an DT cord-005453-4057qib7 2558 7 identical identical JJ cord-005453-4057qib7 2558 8 protocol protocol NN cord-005453-4057qib7 2558 9 using use VBG cord-005453-4057qib7 2558 10 TBI TBI NNP cord-005453-4057qib7 2558 11 - - HYPH cord-005453-4057qib7 2558 12 based base VBN cord-005453-4057qib7 2558 13 myeloablative myeloablative NNP cord-005453-4057qib7 2558 14 preparative preparative JJ cord-005453-4057qib7 2558 15 regimen regimen NN cord-005453-4057qib7 2558 16 ( ( -LRB- cord-005453-4057qib7 2558 17 Fludarabine Fludarabine NNP cord-005453-4057qib7 2559 1 30 30 CD cord-005453-4057qib7 2559 2 mg mg NN cord-005453-4057qib7 2559 3 / / SYM cord-005453-4057qib7 2559 4 m m NN cord-005453-4057qib7 2559 5 2 2 CD cord-005453-4057qib7 2560 1 /d /d NNP cord-005453-4057qib7 2560 2 × × NNP cord-005453-4057qib7 2561 1 4 4 LS cord-005453-4057qib7 2561 2 d d NN cord-005453-4057qib7 2562 1 and and CC cord-005453-4057qib7 2562 2 TBI TBI NNP cord-005453-4057qib7 2562 3 150 150 CD cord-005453-4057qib7 2562 4 cGy cGy NNS cord-005453-4057qib7 2562 5 bid bid VBN cord-005453-4057qib7 2562 6 on on IN cord-005453-4057qib7 2562 7 d d XX cord-005453-4057qib7 2562 8 −4 −4 CD cord-005453-4057qib7 2562 9 to to IN cord-005453-4057qib7 2562 10 −1 −1 NNP cord-005453-4057qib7 2562 11 [ [ -LRB- cord-005453-4057qib7 2562 12 total total JJ cord-005453-4057qib7 2562 13 dose dose NN cord-005453-4057qib7 2562 14 1200 1200 CD cord-005453-4057qib7 2562 15 cGy cGy NNS cord-005453-4057qib7 2562 16 ] ] -RRB- cord-005453-4057qib7 2562 17 ) ) -RRB- cord-005453-4057qib7 2562 18 followed follow VBD cord-005453-4057qib7 2562 19 by by IN cord-005453-4057qib7 2562 20 an an DT cord-005453-4057qib7 2562 21 infusion infusion NN cord-005453-4057qib7 2562 22 of of IN cord-005453-4057qib7 2562 23 unmanipulated unmanipulated JJ cord-005453-4057qib7 2562 24 peripheral peripheral JJ cord-005453-4057qib7 2562 25 blood blood NN cord-005453-4057qib7 2562 26 stem stem NN cord-005453-4057qib7 2562 27 cells cell NNS cord-005453-4057qib7 2562 28 from from IN cord-005453-4057qib7 2562 29 a a DT cord-005453-4057qib7 2562 30 Haploidentical Haploidentical NNP cord-005453-4057qib7 2562 31 family family NN cord-005453-4057qib7 2562 32 donor donor NN cord-005453-4057qib7 2562 33 . . . cord-005453-4057qib7 2563 1 Postgraft postgraft NN cord-005453-4057qib7 2563 2 immunosuppression immunosuppression NN cord-005453-4057qib7 2563 3 consisted consist VBD cord-005453-4057qib7 2563 4 of of IN cord-005453-4057qib7 2563 5 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 2563 6 50 50 CD cord-005453-4057qib7 2563 7 mg mg NNP cord-005453-4057qib7 2563 8 / / SYM cord-005453-4057qib7 2563 9 kg kg NNP cord-005453-4057qib7 2563 10 / / SYM cord-005453-4057qib7 2563 11 day day NN cord-005453-4057qib7 2563 12 on on IN cord-005453-4057qib7 2563 13 days day NNS cord-005453-4057qib7 2563 14 3 3 CD cord-005453-4057qib7 2563 15 and and CC cord-005453-4057qib7 2563 16 4 4 CD cord-005453-4057qib7 2563 17 , , , cord-005453-4057qib7 2563 18 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 2563 19 Mofetil Mofetil NNP cord-005453-4057qib7 2563 20 through through IN cord-005453-4057qib7 2563 21 day day NN cord-005453-4057qib7 2563 22 35 35 CD cord-005453-4057qib7 2563 23 , , , cord-005453-4057qib7 2563 24 and and CC cord-005453-4057qib7 2563 25 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 2563 26 through through IN cord-005453-4057qib7 2563 27 day day NN cord-005453-4057qib7 2563 28 180 180 CD cord-005453-4057qib7 2563 29 . . . cord-005453-4057qib7 2564 1 Results result NNS cord-005453-4057qib7 2564 2 : : : cord-005453-4057qib7 2565 1 Median median JJ cord-005453-4057qib7 2565 2 time time NN cord-005453-4057qib7 2565 3 of of IN cord-005453-4057qib7 2565 4 neutrophil neutrophil NN cord-005453-4057qib7 2565 5 and and CC cord-005453-4057qib7 2565 6 platelet platelet NN cord-005453-4057qib7 2565 7 engraftment engraftment NN cord-005453-4057qib7 2565 8 was be VBD cord-005453-4057qib7 2565 9 11 11 CD cord-005453-4057qib7 2565 10 and and CC cord-005453-4057qib7 2565 11 19 19 CD cord-005453-4057qib7 2565 12 days day NNS cord-005453-4057qib7 2565 13 , , , cord-005453-4057qib7 2565 14 respectively respectively RB cord-005453-4057qib7 2565 15 . . . cord-005453-4057qib7 2566 1 All all DT cord-005453-4057qib7 2566 2 patients patient NNS cord-005453-4057qib7 2566 3 achieved achieve VBD cord-005453-4057qib7 2566 4 sustained sustained JJ cord-005453-4057qib7 2566 5 complete complete JJ cord-005453-4057qib7 2566 6 donor donor NN cord-005453-4057qib7 2566 7 chimerism chimerism NN cord-005453-4057qib7 2566 8 by by IN cord-005453-4057qib7 2566 9 day day NN cord-005453-4057qib7 2566 10 +28 +28 NNS cord-005453-4057qib7 2566 11 . . . cord-005453-4057qib7 2567 1 Acute acute JJ cord-005453-4057qib7 2567 2 GVHD GVHD NNP cord-005453-4057qib7 2567 3 , , , cord-005453-4057qib7 2567 4 grades grade NNS cord-005453-4057qib7 2567 5 II II NNP cord-005453-4057qib7 2567 6 - - HYPH cord-005453-4057qib7 2567 7 IV IV NNP cord-005453-4057qib7 2567 8 and and CC cord-005453-4057qib7 2567 9 III III NNP cord-005453-4057qib7 2567 10 - - HYPH cord-005453-4057qib7 2567 11 IV IV NNP cord-005453-4057qib7 2567 12 , , , cord-005453-4057qib7 2567 13 was be VBD cord-005453-4057qib7 2567 14 seen see VBN cord-005453-4057qib7 2567 15 in in IN cord-005453-4057qib7 2567 16 75 75 CD cord-005453-4057qib7 2567 17 % % NN cord-005453-4057qib7 2567 18 and and CC cord-005453-4057qib7 2567 19 25 25 CD cord-005453-4057qib7 2567 20 % % NN cord-005453-4057qib7 2567 21 , , , cord-005453-4057qib7 2567 22 respectively respectively RB cord-005453-4057qib7 2567 23 . . . cord-005453-4057qib7 2568 1 Disease disease NN cord-005453-4057qib7 2568 2 progression progression NN cord-005453-4057qib7 2568 3 occurred occur VBD cord-005453-4057qib7 2568 4 in in IN cord-005453-4057qib7 2568 5 2 2 CD cord-005453-4057qib7 2568 6 patients patient NNS cord-005453-4057qib7 2568 7 : : : cord-005453-4057qib7 2568 8 8 8 CD cord-005453-4057qib7 2568 9 & & CC cord-005453-4057qib7 2568 10 10 10 CD cord-005453-4057qib7 2568 11 months month NNS cord-005453-4057qib7 2568 12 after after IN cord-005453-4057qib7 2568 13 transplant transplant NN cord-005453-4057qib7 2569 1 and and CC cord-005453-4057qib7 2569 2 there there EX cord-005453-4057qib7 2569 3 was be VBD cord-005453-4057qib7 2569 4 one one CD cord-005453-4057qib7 2569 5 death death NN cord-005453-4057qib7 2569 6 due due IN cord-005453-4057qib7 2569 7 to to IN cord-005453-4057qib7 2569 8 severe severe JJ cord-005453-4057qib7 2569 9 fungal fungal JJ cord-005453-4057qib7 2569 10 infection infection NN cord-005453-4057qib7 2569 11 . . . cord-005453-4057qib7 2570 1 Estimated estimate VBN cord-005453-4057qib7 2570 2 twoyear twoyear JJ cord-005453-4057qib7 2570 3 survival survival NN cord-005453-4057qib7 2570 4 and and CC cord-005453-4057qib7 2570 5 relapse relapse NN cord-005453-4057qib7 2570 6 were be VBD cord-005453-4057qib7 2570 7 75 75 CD cord-005453-4057qib7 2570 8 % % NN cord-005453-4057qib7 2570 9 and and CC cord-005453-4057qib7 2570 10 24 24 CD cord-005453-4057qib7 2570 11 % % NN cord-005453-4057qib7 2570 12 , , , cord-005453-4057qib7 2570 13 respectively respectively RB cord-005453-4057qib7 2570 14 . . . cord-005453-4057qib7 2571 1 2 2 CD cord-005453-4057qib7 2571 2 patients patient NNS cord-005453-4057qib7 2571 3 had have VBD cord-005453-4057qib7 2571 4 severe severe JJ cord-005453-4057qib7 2571 5 BK BK NNP cord-005453-4057qib7 2571 6 viremia viremia NN cord-005453-4057qib7 2571 7 and and CC cord-005453-4057qib7 2571 8 CMV CMV NNP cord-005453-4057qib7 2571 9 reactivation reactivation NN cord-005453-4057qib7 2571 10 occurred occur VBD cord-005453-4057qib7 2571 11 in in IN cord-005453-4057qib7 2571 12 4 4 CD cord-005453-4057qib7 2571 13 patients patient NNS cord-005453-4057qib7 2571 14 . . . cord-005453-4057qib7 2572 1 All all DT cord-005453-4057qib7 2572 2 patients patient NNS cord-005453-4057qib7 2572 3 were be VBD cord-005453-4057qib7 2572 4 successfully successfully RB cord-005453-4057qib7 2572 5 managed manage VBN cord-005453-4057qib7 2572 6 with with IN cord-005453-4057qib7 2572 7 appropriate appropriate JJ cord-005453-4057qib7 2572 8 supportive supportive JJ cord-005453-4057qib7 2572 9 and and CC cord-005453-4057qib7 2572 10 antiviral antiviral JJ cord-005453-4057qib7 2572 11 therapy therapy NN cord-005453-4057qib7 2572 12 . . . cord-005453-4057qib7 2573 1 Conclusions conclusion NNS cord-005453-4057qib7 2573 2 : : : cord-005453-4057qib7 2574 1 We -PRON- PRP cord-005453-4057qib7 2574 2 report report VBP cord-005453-4057qib7 2574 3 good good JJ cord-005453-4057qib7 2574 4 outcome outcome NN cord-005453-4057qib7 2574 5 with with IN cord-005453-4057qib7 2574 6 a a DT cord-005453-4057qib7 2574 7 myeloablative myeloablative JJ cord-005453-4057qib7 2574 8 conditioning conditioning NN cord-005453-4057qib7 2574 9 in in IN cord-005453-4057qib7 2574 10 haploidentical haploidentical JJ cord-005453-4057qib7 2574 11 transplants transplant NNS cord-005453-4057qib7 2574 12 with with IN cord-005453-4057qib7 2574 13 excellent excellent JJ cord-005453-4057qib7 2574 14 engraftment engraftment NN cord-005453-4057qib7 2574 15 and and CC cord-005453-4057qib7 2574 16 hopefully hopefully RB cord-005453-4057qib7 2574 17 a a DT cord-005453-4057qib7 2574 18 longer long JJR cord-005453-4057qib7 2574 19 life life NN cord-005453-4057qib7 2574 20 expectancy expectancy NN cord-005453-4057qib7 2574 21 . . . cord-005453-4057qib7 2575 1 With with IN cord-005453-4057qib7 2575 2 small small JJ cord-005453-4057qib7 2575 3 number number NN cord-005453-4057qib7 2575 4 of of IN cord-005453-4057qib7 2575 5 patients patient NNS cord-005453-4057qib7 2575 6 , , , cord-005453-4057qib7 2575 7 it -PRON- PRP cord-005453-4057qib7 2575 8 is be VBZ cord-005453-4057qib7 2575 9 difficult difficult JJ cord-005453-4057qib7 2575 10 to to TO cord-005453-4057qib7 2575 11 state state VB cord-005453-4057qib7 2575 12 whether whether IN cord-005453-4057qib7 2575 13 using use VBG cord-005453-4057qib7 2575 14 a a DT cord-005453-4057qib7 2575 15 myeloablative myeloablative JJ cord-005453-4057qib7 2575 16 conditioning conditioning NN cord-005453-4057qib7 2575 17 would would MD cord-005453-4057qib7 2575 18 lead lead VB cord-005453-4057qib7 2575 19 to to IN cord-005453-4057qib7 2575 20 better well JJR cord-005453-4057qib7 2575 21 long long JJ cord-005453-4057qib7 2575 22 term term NN cord-005453-4057qib7 2575 23 outcomes outcome NNS cord-005453-4057qib7 2575 24 in in IN cord-005453-4057qib7 2575 25 this this DT cord-005453-4057qib7 2575 26 cohort cohort NN cord-005453-4057qib7 2575 27 of of IN cord-005453-4057qib7 2575 28 patients patient NNS cord-005453-4057qib7 2575 29 with with IN cord-005453-4057qib7 2575 30 very very RB cord-005453-4057qib7 2575 31 haematological haematological JJ cord-005453-4057qib7 2575 32 malignancies malignancy NNS cord-005453-4057qib7 2575 33 , , , cord-005453-4057qib7 2575 34 but but CC cord-005453-4057qib7 2575 35 we -PRON- PRP cord-005453-4057qib7 2575 36 certainly certainly RB cord-005453-4057qib7 2575 37 showed show VBD cord-005453-4057qib7 2575 38 that that IN cord-005453-4057qib7 2575 39 it -PRON- PRP cord-005453-4057qib7 2575 40 is be VBZ cord-005453-4057qib7 2575 41 possible possible JJ cord-005453-4057qib7 2575 42 to to TO cord-005453-4057qib7 2575 43 achieve achieve VB cord-005453-4057qib7 2575 44 excellent excellent JJ cord-005453-4057qib7 2575 45 early early JJ cord-005453-4057qib7 2575 46 results result NNS cord-005453-4057qib7 2575 47 . . . cord-005453-4057qib7 2576 1 Disclosure disclosure NN cord-005453-4057qib7 2576 2 : : : cord-005453-4057qib7 2576 3 Nothing nothing NN cord-005453-4057qib7 2576 4 to to TO cord-005453-4057qib7 2576 5 declare declare VB cord-005453-4057qib7 2576 6 Fludarabine Fludarabine NNP cord-005453-4057qib7 2576 7 in in IN cord-005453-4057qib7 2576 8 combination combination NN cord-005453-4057qib7 2576 9 with with IN cord-005453-4057qib7 2576 10 melphalan melphalan NNP cord-005453-4057qib7 2576 11 and and CC cord-005453-4057qib7 2576 12 ATG ATG NNP cord-005453-4057qib7 2576 13 can can MD cord-005453-4057qib7 2576 14 be be VB cord-005453-4057qib7 2576 15 the the DT cord-005453-4057qib7 2576 16 best good JJS cord-005453-4057qib7 2576 17 conditioning conditioning NN cord-005453-4057qib7 2576 18 for for IN cord-005453-4057qib7 2576 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 2576 20 stem stem NN cord-005453-4057qib7 2576 21 cell cell NN cord-005453-4057qib7 2576 22 transplant transplant NN cord-005453-4057qib7 2576 23 of of IN cord-005453-4057qib7 2576 24 children child NNS cord-005453-4057qib7 2576 25 with with IN cord-005453-4057qib7 2576 26 hemophagocytic hemophagocytic JJ cord-005453-4057qib7 2576 27 lymphohistiocytosis lymphohistiocytosis NN cord-005453-4057qib7 2576 28 Methods method NNS cord-005453-4057qib7 2577 1 : : : cord-005453-4057qib7 2577 2 In in IN cord-005453-4057qib7 2577 3 this this DT cord-005453-4057qib7 2577 4 prospective prospective JJ cord-005453-4057qib7 2577 5 study study NN cord-005453-4057qib7 2577 6 , , , cord-005453-4057qib7 2577 7 we -PRON- PRP cord-005453-4057qib7 2577 8 analyzed analyze VBD cord-005453-4057qib7 2577 9 the the DT cord-005453-4057qib7 2577 10 outcome outcome NN cord-005453-4057qib7 2577 11 of of IN cord-005453-4057qib7 2577 12 two two CD cord-005453-4057qib7 2577 13 pediatric pediatric JJ cord-005453-4057qib7 2577 14 patients patient NNS cord-005453-4057qib7 2577 15 with with IN cord-005453-4057qib7 2577 16 HLH HLH NNP cord-005453-4057qib7 2577 17 who who WP cord-005453-4057qib7 2577 18 had have VBD cord-005453-4057qib7 2577 19 received receive VBN cord-005453-4057qib7 2577 20 HSCT HSCT NNP cord-005453-4057qib7 2577 21 , , , cord-005453-4057qib7 2577 22 using use VBG cord-005453-4057qib7 2577 23 reduced reduce VBN cord-005453-4057qib7 2577 24 - - HYPH cord-005453-4057qib7 2577 25 intensity intensity NN cord-005453-4057qib7 2577 26 conditioning conditioning NN cord-005453-4057qib7 2577 27 ( ( -LRB- cord-005453-4057qib7 2577 28 RIC RIC NNP cord-005453-4057qib7 2577 29 ) ) -RRB- cord-005453-4057qib7 2577 30 regimen regimen NN cord-005453-4057qib7 2577 31 . . . cord-005453-4057qib7 2578 1 They -PRON- PRP cord-005453-4057qib7 2578 2 received receive VBD cord-005453-4057qib7 2578 3 the the DT cord-005453-4057qib7 2578 4 same same JJ cord-005453-4057qib7 2578 5 RIC RIC NNP cord-005453-4057qib7 2578 6 regimen regimen NN cord-005453-4057qib7 2578 7 based base VBN cord-005453-4057qib7 2578 8 on on IN cord-005453-4057qib7 2578 9 the the DT cord-005453-4057qib7 2578 10 use use NN cord-005453-4057qib7 2578 11 of of IN cord-005453-4057qib7 2578 12 Fludarabine Fludarabine NNP cord-005453-4057qib7 2578 13 ( ( -LRB- cord-005453-4057qib7 2578 14 30 30 CD cord-005453-4057qib7 2578 15 mg mg NN cord-005453-4057qib7 2578 16 / / SYM cord-005453-4057qib7 2578 17 m m NN cord-005453-4057qib7 2578 18 2 2 CD cord-005453-4057qib7 2578 19 /day /day . cord-005453-4057qib7 2578 20 for for IN cord-005453-4057qib7 2578 21 5 5 CD cord-005453-4057qib7 2578 22 days day NNS cord-005453-4057qib7 2578 23 ) ) -RRB- cord-005453-4057qib7 2578 24 in in IN cord-005453-4057qib7 2578 25 combination combination NN cord-005453-4057qib7 2578 26 with with IN cord-005453-4057qib7 2578 27 melphalan melphalan NNP cord-005453-4057qib7 2578 28 ( ( -LRB- cord-005453-4057qib7 2578 29 70 70 CD cord-005453-4057qib7 2578 30 mg mg NNP cord-005453-4057qib7 2578 31 / / SYM cord-005453-4057qib7 2578 32 m m NN cord-005453-4057qib7 2578 33 2 2 CD cord-005453-4057qib7 2578 34 /day /day . cord-005453-4057qib7 2578 35 for for IN cord-005453-4057qib7 2578 36 2 2 CD cord-005453-4057qib7 2578 37 days day NNS cord-005453-4057qib7 2578 38 ) ) -RRB- cord-005453-4057qib7 2578 39 and and CC cord-005453-4057qib7 2578 40 horse horse NN cord-005453-4057qib7 2578 41 antithymocyte antithymocyte NNP cord-005453-4057qib7 2578 42 globulin globulin NN cord-005453-4057qib7 2578 43 ( ( -LRB- cord-005453-4057qib7 2579 1 ATG ATG NNP cord-005453-4057qib7 2579 2 10 10 CD cord-005453-4057qib7 2579 3 mg mg NNP cord-005453-4057qib7 2579 4 / / SYM cord-005453-4057qib7 2579 5 kg kg NNP cord-005453-4057qib7 2579 6 / / SYM cord-005453-4057qib7 2579 7 d d NN cord-005453-4057qib7 2579 8 for for IN cord-005453-4057qib7 2579 9 4 4 CD cord-005453-4057qib7 2579 10 days day NNS cord-005453-4057qib7 2579 11 ) ) -RRB- cord-005453-4057qib7 2579 12 . . . cord-005453-4057qib7 2580 1 Cyclosporine Cyclosporine NNP cord-005453-4057qib7 2580 2 and and CC cord-005453-4057qib7 2580 3 Methotrexate Methotrexate NNP cord-005453-4057qib7 2580 4 were be VBD cord-005453-4057qib7 2580 5 used use VBN cord-005453-4057qib7 2580 6 as as IN cord-005453-4057qib7 2580 7 graft graft NN cord-005453-4057qib7 2580 8 - - HYPH cord-005453-4057qib7 2580 9 vs.-host vs.-host NN cord-005453-4057qib7 2580 10 disease disease NN cord-005453-4057qib7 2580 11 ( ( -LRB- cord-005453-4057qib7 2580 12 GvHD GvHD NNP cord-005453-4057qib7 2580 13 ) ) -RRB- cord-005453-4057qib7 2580 14 prophylaxis prophylaxis NN cord-005453-4057qib7 2580 15 . . . cord-005453-4057qib7 2581 1 Results result NNS cord-005453-4057qib7 2581 2 : : : cord-005453-4057qib7 2582 1 A a DT cord-005453-4057qib7 2582 2 2 2 CD cord-005453-4057qib7 2582 3 months month NNS cord-005453-4057qib7 2582 4 boy boy NN cord-005453-4057qib7 2582 5 with with IN cord-005453-4057qib7 2582 6 primary primary JJ cord-005453-4057qib7 2582 7 HLH HLH NNP cord-005453-4057qib7 2582 8 ( ( -LRB- cord-005453-4057qib7 2582 9 FHL2 FHL2 NNP cord-005453-4057qib7 2582 10 ) ) -RRB- cord-005453-4057qib7 2582 11 was be VBD cord-005453-4057qib7 2582 12 transplanted transplant VBN cord-005453-4057qib7 2582 13 from from IN cord-005453-4057qib7 2582 14 his -PRON- PRP$ cord-005453-4057qib7 2582 15 mother mother NN cord-005453-4057qib7 2582 16 and and CC cord-005453-4057qib7 2582 17 a a DT cord-005453-4057qib7 2582 18 4 4 CD cord-005453-4057qib7 2582 19 years year NNS cord-005453-4057qib7 2582 20 girl girl NN cord-005453-4057qib7 2582 21 with with IN cord-005453-4057qib7 2582 22 secondary secondary JJ cord-005453-4057qib7 2582 23 HLH HLH NNP cord-005453-4057qib7 2582 24 was be VBD cord-005453-4057qib7 2582 25 transplanted transplant VBN cord-005453-4057qib7 2582 26 from from IN cord-005453-4057qib7 2582 27 her -PRON- PRP$ cord-005453-4057qib7 2582 28 brother brother NN cord-005453-4057qib7 2582 29 . . . cord-005453-4057qib7 2583 1 Both both DT cord-005453-4057qib7 2583 2 of of IN cord-005453-4057qib7 2583 3 donors donor NNS cord-005453-4057qib7 2583 4 were be VBD cord-005453-4057qib7 2583 5 HLA HLA NNP cord-005453-4057qib7 2583 6 match match NN cord-005453-4057qib7 2583 7 with with IN cord-005453-4057qib7 2583 8 their -PRON- PRP$ cord-005453-4057qib7 2583 9 recipients recipient NNS cord-005453-4057qib7 2583 10 . . . cord-005453-4057qib7 2584 1 They -PRON- PRP cord-005453-4057qib7 2584 2 were be VBD cord-005453-4057qib7 2584 3 received receive VBN cord-005453-4057qib7 2584 4 6 6 CD cord-005453-4057qib7 2584 5 x x SYM cord-005453-4057qib7 2584 6 10 10 CD cord-005453-4057qib7 2584 7 6 6 CD cord-005453-4057qib7 2584 8 /kg /kg CD cord-005453-4057qib7 2584 9 and and CC cord-005453-4057qib7 2584 10 10 10 CD cord-005453-4057qib7 2584 11 x x SYM cord-005453-4057qib7 2584 12 10 10 CD cord-005453-4057qib7 2584 13 6 6 CD cord-005453-4057qib7 2584 14 /kg /kg . cord-005453-4057qib7 2584 15 CD34 CD34 NNP cord-005453-4057qib7 2584 16 + + CC cord-005453-4057qib7 2584 17 cells cell NNS cord-005453-4057qib7 2584 18 from from IN cord-005453-4057qib7 2584 19 the the DT cord-005453-4057qib7 2584 20 harvested harvest VBN cord-005453-4057qib7 2584 21 peripheral peripheral JJ cord-005453-4057qib7 2584 22 blood blood NN cord-005453-4057qib7 2584 23 stem stem NN cord-005453-4057qib7 2584 24 cells cell NNS cord-005453-4057qib7 2584 25 , , , cord-005453-4057qib7 2584 26 respectively respectively RB cord-005453-4057qib7 2584 27 . . . cord-005453-4057qib7 2585 1 They -PRON- PRP cord-005453-4057qib7 2585 2 achieved achieve VBD cord-005453-4057qib7 2585 3 full full JJ cord-005453-4057qib7 2585 4 neutrophil neutrophil NN cord-005453-4057qib7 2585 5 and and CC cord-005453-4057qib7 2585 6 platelet platelet NN cord-005453-4057qib7 2585 7 recovery recovery NN cord-005453-4057qib7 2585 8 . . . cord-005453-4057qib7 2586 1 The the DT cord-005453-4057qib7 2586 2 time time NN cord-005453-4057qib7 2586 3 to to IN cord-005453-4057qib7 2586 4 neutrophil neutrophil NN cord-005453-4057qib7 2586 5 recovery recovery NN cord-005453-4057qib7 2586 6 was be VBD cord-005453-4057qib7 2586 7 13 13 CD cord-005453-4057qib7 2586 8 and and CC cord-005453-4057qib7 2586 9 11 11 CD cord-005453-4057qib7 2586 10 days day NNS cord-005453-4057qib7 2586 11 , , , cord-005453-4057qib7 2586 12 respectively respectively RB cord-005453-4057qib7 2586 13 . . . cord-005453-4057qib7 2587 1 Full full JJ cord-005453-4057qib7 2587 2 chimerism chimerism NN cord-005453-4057qib7 2587 3 was be VBD cord-005453-4057qib7 2587 4 achieved achieve VBN cord-005453-4057qib7 2587 5 for for IN cord-005453-4057qib7 2587 6 both both DT cord-005453-4057qib7 2587 7 of of IN cord-005453-4057qib7 2587 8 them -PRON- PRP cord-005453-4057qib7 2587 9 . . . cord-005453-4057qib7 2588 1 In in IN cord-005453-4057qib7 2588 2 addition addition NN cord-005453-4057qib7 2588 3 , , , cord-005453-4057qib7 2588 4 they -PRON- PRP cord-005453-4057qib7 2588 5 was be VBD cord-005453-4057qib7 2588 6 developed develop VBN cord-005453-4057qib7 2588 7 grade grade NN cord-005453-4057qib7 2588 8 3 3 CD cord-005453-4057qib7 2588 9 and and CC cord-005453-4057qib7 2588 10 2 2 CD cord-005453-4057qib7 2588 11 of of IN cord-005453-4057qib7 2588 12 acute acute JJ cord-005453-4057qib7 2588 13 GvHD gvhd NN cord-005453-4057qib7 2588 14 , , , cord-005453-4057qib7 2588 15 respectively respectively RB cord-005453-4057qib7 2588 16 . . . cord-005453-4057qib7 2589 1 GvHD GvHD NNP cord-005453-4057qib7 2589 2 was be VBD cord-005453-4057qib7 2589 3 completely completely RB cord-005453-4057qib7 2589 4 controlled control VBN cord-005453-4057qib7 2589 5 with with IN cord-005453-4057qib7 2589 6 prednisolone prednisolone NN cord-005453-4057qib7 2589 7 . . . cord-005453-4057qib7 2590 1 They -PRON- PRP cord-005453-4057qib7 2590 2 are be VBP cord-005453-4057qib7 2590 3 alive alive JJ cord-005453-4057qib7 2590 4 and and CC cord-005453-4057qib7 2590 5 in in IN cord-005453-4057qib7 2590 6 complete complete JJ cord-005453-4057qib7 2590 7 remission remission NN cord-005453-4057qib7 2590 8 without without IN cord-005453-4057qib7 2590 9 any any DT cord-005453-4057qib7 2590 10 significant significant JJ cord-005453-4057qib7 2590 11 complications complication NNS cord-005453-4057qib7 2590 12 after after IN cord-005453-4057qib7 2590 13 36 36 CD cord-005453-4057qib7 2590 14 and and CC cord-005453-4057qib7 2590 15 14 14 CD cord-005453-4057qib7 2590 16 months month NNS cord-005453-4057qib7 2590 17 , , , cord-005453-4057qib7 2590 18 respectively respectively RB cord-005453-4057qib7 2590 19 . . . cord-005453-4057qib7 2591 1 Conclusions conclusion NNS cord-005453-4057qib7 2591 2 : : : cord-005453-4057qib7 2592 1 It -PRON- PRP cord-005453-4057qib7 2592 2 appears appear VBZ cord-005453-4057qib7 2592 3 that that IN cord-005453-4057qib7 2592 4 Fludarabine Fludarabine NNP cord-005453-4057qib7 2592 5 in in IN cord-005453-4057qib7 2592 6 combination combination NN cord-005453-4057qib7 2592 7 with with IN cord-005453-4057qib7 2592 8 Melphalan Melphalan NNP cord-005453-4057qib7 2592 9 and and CC cord-005453-4057qib7 2592 10 ATG ATG NNP cord-005453-4057qib7 2592 11 may may MD cord-005453-4057qib7 2592 12 be be VB cord-005453-4057qib7 2592 13 the the DT cord-005453-4057qib7 2592 14 best good JJS cord-005453-4057qib7 2592 15 conditioning conditioning NN cord-005453-4057qib7 2592 16 regimen regimen NN cord-005453-4057qib7 2592 17 for for IN cord-005453-4057qib7 2592 18 hematopoietic hematopoietic JJ cord-005453-4057qib7 2592 19 stem stem NN cord-005453-4057qib7 2592 20 cell cell NN cord-005453-4057qib7 2592 21 transplant transplant NN cord-005453-4057qib7 2592 22 of of IN cord-005453-4057qib7 2592 23 children child NNS cord-005453-4057qib7 2592 24 with with IN cord-005453-4057qib7 2592 25 HLH HLH NNP cord-005453-4057qib7 2592 26 . . . cord-005453-4057qib7 2593 1 Due due IN cord-005453-4057qib7 2593 2 to to IN cord-005453-4057qib7 2593 3 a a DT cord-005453-4057qib7 2593 4 few few JJ cord-005453-4057qib7 2593 5 number number NN cord-005453-4057qib7 2593 6 cases case NNS cord-005453-4057qib7 2593 7 of of IN cord-005453-4057qib7 2593 8 this this DT cord-005453-4057qib7 2593 9 study study NN cord-005453-4057qib7 2593 10 , , , cord-005453-4057qib7 2593 11 a a DT cord-005453-4057qib7 2593 12 study study NN cord-005453-4057qib7 2593 13 with with IN cord-005453-4057qib7 2593 14 sufficient sufficient JJ cord-005453-4057qib7 2593 15 sample sample NN cord-005453-4057qib7 2593 16 size size NN cord-005453-4057qib7 2593 17 is be VBZ cord-005453-4057qib7 2593 18 required require VBN cord-005453-4057qib7 2593 19 . . . cord-005453-4057qib7 2594 1 Disclosure disclosure NN cord-005453-4057qib7 2594 2 Background background NN cord-005453-4057qib7 2594 3 : : : cord-005453-4057qib7 2594 4 Hematopoietic hematopoietic JJ cord-005453-4057qib7 2594 5 cell cell NN cord-005453-4057qib7 2594 6 transplant transplant NN cord-005453-4057qib7 2594 7 ( ( -LRB- cord-005453-4057qib7 2594 8 HCT HCT NNP cord-005453-4057qib7 2594 9 ) ) -RRB- cord-005453-4057qib7 2594 10 recipients recipient NNS cord-005453-4057qib7 2594 11 often often RB cord-005453-4057qib7 2594 12 report report VBP cord-005453-4057qib7 2594 13 depression depression NN cord-005453-4057qib7 2594 14 and and CC cord-005453-4057qib7 2594 15 impaired impaired JJ cord-005453-4057qib7 2594 16 quality quality NN cord-005453-4057qib7 2594 17 of of IN cord-005453-4057qib7 2594 18 life life NN cord-005453-4057qib7 2594 19 ( ( -LRB- cord-005453-4057qib7 2594 20 QOL QOL NNP cord-005453-4057qib7 2594 21 ) ) -RRB- cord-005453-4057qib7 2594 22 before before IN cord-005453-4057qib7 2594 23 transplant transplant NN cord-005453-4057qib7 2594 24 . . . cord-005453-4057qib7 2595 1 Mixed mixed JJ cord-005453-4057qib7 2595 2 evidence evidence NN cord-005453-4057qib7 2595 3 suggests suggest VBZ cord-005453-4057qib7 2595 4 depression depression NN cord-005453-4057qib7 2595 5 may may MD cord-005453-4057qib7 2595 6 be be VB cord-005453-4057qib7 2595 7 a a DT cord-005453-4057qib7 2595 8 risk risk NN cord-005453-4057qib7 2595 9 factor factor NN cord-005453-4057qib7 2595 10 for for IN cord-005453-4057qib7 2595 11 greater great JJR cord-005453-4057qib7 2595 12 mortality mortality NN cord-005453-4057qib7 2595 13 and and CC cord-005453-4057qib7 2595 14 worse bad JJR cord-005453-4057qib7 2595 15 QoL. QoL. NNP cord-005453-4057qib7 2595 16 Inconsistent inconsistent JJ cord-005453-4057qib7 2595 17 findings finding NNS cord-005453-4057qib7 2595 18 may may MD cord-005453-4057qib7 2595 19 be be VB cord-005453-4057qib7 2595 20 due due JJ cord-005453-4057qib7 2595 21 to to IN cord-005453-4057qib7 2595 22 the the DT cord-005453-4057qib7 2595 23 fact fact NN cord-005453-4057qib7 2595 24 that that IN cord-005453-4057qib7 2595 25 previous previous JJ cord-005453-4057qib7 2595 26 studies study NNS cord-005453-4057qib7 2595 27 have have VBP cord-005453-4057qib7 2595 28 not not RB cord-005453-4057qib7 2595 29 evaluated evaluate VBN cord-005453-4057qib7 2595 30 antidepressant antidepressant JJ cord-005453-4057qib7 2595 31 use use NN cord-005453-4057qib7 2595 32 . . . cord-005453-4057qib7 2596 1 The the DT cord-005453-4057qib7 2596 2 aim aim NN cord-005453-4057qib7 2596 3 of of IN cord-005453-4057qib7 2596 4 the the DT cord-005453-4057qib7 2596 5 study study NN cord-005453-4057qib7 2596 6 was be VBD cord-005453-4057qib7 2596 7 to to TO cord-005453-4057qib7 2596 8 compare compare VB cord-005453-4057qib7 2596 9 pre pre JJ cord-005453-4057qib7 2596 10 - - JJ cord-005453-4057qib7 2596 11 transplant transplant JJ cord-005453-4057qib7 2596 12 patientreported patientreporte VBN cord-005453-4057qib7 2596 13 physical physical JJ cord-005453-4057qib7 2596 14 functioning functioning NN cord-005453-4057qib7 2596 15 and and CC cord-005453-4057qib7 2596 16 post post JJ cord-005453-4057qib7 2596 17 - - JJ cord-005453-4057qib7 2596 18 transplant transplant JJ cord-005453-4057qib7 2596 19 overall overall JJ cord-005453-4057qib7 2596 20 survival survival NN cord-005453-4057qib7 2596 21 ( ( -LRB- cord-005453-4057qib7 2596 22 OS OS NNP cord-005453-4057qib7 2596 23 ) ) -RRB- cord-005453-4057qib7 2596 24 between between IN cord-005453-4057qib7 2596 25 four four CD cord-005453-4057qib7 2596 26 groups group NNS cord-005453-4057qib7 2596 27 of of IN cord-005453-4057qib7 2596 28 HCT HCT NNP cord-005453-4057qib7 2596 29 recipients recipient NNS cord-005453-4057qib7 2596 30 : : : cord-005453-4057qib7 2596 31 1 1 LS cord-005453-4057qib7 2596 32 ) ) -RRB- cord-005453-4057qib7 2596 33 non non JJ cord-005453-4057qib7 2596 34 - - JJ cord-005453-4057qib7 2596 35 depressed depressed JJ cord-005453-4057qib7 2596 36 / / SYM cord-005453-4057qib7 2596 37 taking take VBG cord-005453-4057qib7 2596 38 antidepressant antidepressant JJ cord-005453-4057qib7 2596 39 ( ( -LRB- cord-005453-4057qib7 2596 40 treated treat VBN cord-005453-4057qib7 2596 41 depression depression NN cord-005453-4057qib7 2596 42 ) ) -RRB- cord-005453-4057qib7 2596 43 , , , cord-005453-4057qib7 2596 44 2 2 CD cord-005453-4057qib7 2596 45 ) ) -RRB- cord-005453-4057qib7 2597 1 depressed depressed JJ cord-005453-4057qib7 2597 2 / / SYM cord-005453-4057qib7 2597 3 taking take VBG cord-005453-4057qib7 2597 4 antidepressant antidepressant JJ cord-005453-4057qib7 2597 5 ( ( -LRB- cord-005453-4057qib7 2597 6 undertreated undertreated JJ cord-005453-4057qib7 2597 7 depression depression NN cord-005453-4057qib7 2597 8 ) ) -RRB- cord-005453-4057qib7 2597 9 , , . cord-005453-4057qib7 2598 1 3 3 LS cord-005453-4057qib7 2598 2 ) ) -RRB- cord-005453-4057qib7 2598 3 depressed depressed JJ cord-005453-4057qib7 2598 4 / / , cord-005453-4057qib7 2598 5 not not RB cord-005453-4057qib7 2598 6 taking take VBG cord-005453-4057qib7 2598 7 an an DT cord-005453-4057qib7 2598 8 antidepressant antidepressant NN cord-005453-4057qib7 2598 9 ( ( -LRB- cord-005453-4057qib7 2598 10 untreated untreated JJ cord-005453-4057qib7 2598 11 depression depression NN cord-005453-4057qib7 2598 12 ) ) -RRB- cord-005453-4057qib7 2598 13 , , , cord-005453-4057qib7 2598 14 and and CC cord-005453-4057qib7 2598 15 4 4 LS cord-005453-4057qib7 2598 16 ) ) -RRB- cord-005453-4057qib7 2598 17 not not RB cord-005453-4057qib7 2598 18 depressed depressed JJ cord-005453-4057qib7 2598 19 / / SYM cord-005453-4057qib7 2598 20 not not RB cord-005453-4057qib7 2598 21 taking take VBG cord-005453-4057qib7 2598 22 an an DT cord-005453-4057qib7 2598 23 antidepressant antidepressant NN cord-005453-4057qib7 2598 24 ( ( -LRB- cord-005453-4057qib7 2598 25 control control NN cord-005453-4057qib7 2598 26 ) ) -RRB- cord-005453-4057qib7 2598 27 . . . cord-005453-4057qib7 2599 1 It -PRON- PRP cord-005453-4057qib7 2599 2 was be VBD cord-005453-4057qib7 2599 3 hypothesized hypothesize VBN cord-005453-4057qib7 2599 4 that that IN cord-005453-4057qib7 2599 5 physical physical JJ cord-005453-4057qib7 2599 6 functioning functioning NN cord-005453-4057qib7 2599 7 and and CC cord-005453-4057qib7 2599 8 OS OS NNP cord-005453-4057qib7 2599 9 would would MD cord-005453-4057qib7 2599 10 be be VB cord-005453-4057qib7 2599 11 worse bad JJR cord-005453-4057qib7 2599 12 among among IN cord-005453-4057qib7 2599 13 patients patient NNS cord-005453-4057qib7 2599 14 with with IN cord-005453-4057qib7 2599 15 untreated untreated JJ cord-005453-4057qib7 2599 16 and and CC cord-005453-4057qib7 2599 17 undertreated undertreated JJ cord-005453-4057qib7 2599 18 depression depression NN cord-005453-4057qib7 2599 19 relative relative JJ cord-005453-4057qib7 2599 20 to to IN cord-005453-4057qib7 2599 21 those those DT cord-005453-4057qib7 2599 22 with with IN cord-005453-4057qib7 2599 23 treated treat VBN cord-005453-4057qib7 2599 24 depression depression NN cord-005453-4057qib7 2599 25 and and CC cord-005453-4057qib7 2599 26 controls control NNS cord-005453-4057qib7 2599 27 . . . cord-005453-4057qib7 2600 1 Methods method NNS cord-005453-4057qib7 2600 2 : : : cord-005453-4057qib7 2601 1 This this DT cord-005453-4057qib7 2601 2 retrospective retrospective JJ cord-005453-4057qib7 2601 3 case case NN cord-005453-4057qib7 2601 4 - - HYPH cord-005453-4057qib7 2601 5 control control NN cord-005453-4057qib7 2601 6 study study NN cord-005453-4057qib7 2601 7 included include VBD cord-005453-4057qib7 2601 8 patients patient NNS cord-005453-4057qib7 2601 9 completing complete VBG cord-005453-4057qib7 2601 10 depression depression NN cord-005453-4057qib7 2601 11 ( ( -LRB- cord-005453-4057qib7 2601 12 PHQ-8 PHQ-8 NNP cord-005453-4057qib7 2601 13 ) ) -RRB- cord-005453-4057qib7 2601 14 and and CC cord-005453-4057qib7 2601 15 quality quality NN cord-005453-4057qib7 2601 16 of of IN cord-005453-4057qib7 2601 17 life life NN cord-005453-4057qib7 2601 18 ( ( -LRB- cord-005453-4057qib7 2601 19 SF-12 SF-12 NNP cord-005453-4057qib7 2601 20 ) ) -RRB- cord-005453-4057qib7 2601 21 questionnaires questionnaire VBZ cord-005453-4057qib7 2601 22 at at IN cord-005453-4057qib7 2601 23 pre pre NN cord-005453-4057qib7 2601 24 - - NN cord-005453-4057qib7 2601 25 transplant transplant NN cord-005453-4057qib7 2601 26 . . . cord-005453-4057qib7 2602 1 Analyses analysis NNS cord-005453-4057qib7 2602 2 were be VBD cord-005453-4057qib7 2602 3 conducted conduct VBN cord-005453-4057qib7 2602 4 separately separately RB cord-005453-4057qib7 2602 5 for for IN cord-005453-4057qib7 2602 6 allogeneic allogeneic NN cord-005453-4057qib7 2602 7 and and CC cord-005453-4057qib7 2602 8 autologous autologous JJ cord-005453-4057qib7 2602 9 recipients recipient NNS cord-005453-4057qib7 2602 10 . . . cord-005453-4057qib7 2603 1 Results result NNS cord-005453-4057qib7 2603 2 : : : cord-005453-4057qib7 2604 1 Participants participant NNS cord-005453-4057qib7 2604 2 ( ( -LRB- cord-005453-4057qib7 2604 3 N=1,797 N=1,797 NNP cord-005453-4057qib7 2604 4 ) ) -RRB- cord-005453-4057qib7 2604 5 were be VBD cord-005453-4057qib7 2604 6 58 58 CD cord-005453-4057qib7 2604 7 % % NN cord-005453-4057qib7 2604 8 men man NNS cord-005453-4057qib7 2604 9 , , , cord-005453-4057qib7 2604 10 mean mean VB cord-005453-4057qib7 2604 11 age age NN cord-005453-4057qib7 2604 12 57 57 CD cord-005453-4057qib7 2604 13 years year NNS cord-005453-4057qib7 2604 14 ( ( -LRB- cord-005453-4057qib7 2604 15 19 19 CD cord-005453-4057qib7 2604 16 - - SYM cord-005453-4057qib7 2604 17 79 79 CD cord-005453-4057qib7 2604 18 ) ) -RRB- cord-005453-4057qib7 2604 19 , , , cord-005453-4057qib7 2604 20 39 39 CD cord-005453-4057qib7 2604 21 % % NN cord-005453-4057qib7 2604 22 allogeneic allogeneic IN cord-005453-4057qib7 2604 23 recipients recipient NNS cord-005453-4057qib7 2604 24 . . . cord-005453-4057qib7 2605 1 Regarding regard VBG cord-005453-4057qib7 2605 2 depression depression NN cord-005453-4057qib7 2605 3 and and CC cord-005453-4057qib7 2605 4 antidepressant antidepressant JJ cord-005453-4057qib7 2605 5 use use NN cord-005453-4057qib7 2605 6 , , , cord-005453-4057qib7 2605 7 146 146 CD cord-005453-4057qib7 2605 8 ( ( -LRB- cord-005453-4057qib7 2605 9 21 21 CD cord-005453-4057qib7 2605 10 % % NN cord-005453-4057qib7 2605 11 ) ) -RRB- cord-005453-4057qib7 2605 12 allogeneic allogeneic NN cord-005453-4057qib7 2605 13 patients patient NNS cord-005453-4057qib7 2605 14 were be VBD cord-005453-4057qib7 2605 15 characterized characterize VBN cord-005453-4057qib7 2605 16 as as IN cord-005453-4057qib7 2605 17 having have VBG cord-005453-4057qib7 2605 18 treated treat VBN cord-005453-4057qib7 2605 19 depression depression NN cord-005453-4057qib7 2605 20 , , , cord-005453-4057qib7 2605 21 47 47 CD cord-005453-4057qib7 2605 22 ( ( -LRB- cord-005453-4057qib7 2605 23 7 7 CD cord-005453-4057qib7 2605 24 % % NN cord-005453-4057qib7 2605 25 ) ) -RRB- cord-005453-4057qib7 2605 26 as as IN cord-005453-4057qib7 2605 27 untreated untreated JJ cord-005453-4057qib7 2605 28 depression depression NN cord-005453-4057qib7 2605 29 , , , cord-005453-4057qib7 2605 30 49 49 CD cord-005453-4057qib7 2605 31 ( ( -LRB- cord-005453-4057qib7 2605 32 7 7 CD cord-005453-4057qib7 2605 33 % % NN cord-005453-4057qib7 2605 34 ) ) -RRB- cord-005453-4057qib7 2605 35 as as IN cord-005453-4057qib7 2605 36 undertreated undertreated JJ cord-005453-4057qib7 2605 37 depression depression NN cord-005453-4057qib7 2605 38 , , , cord-005453-4057qib7 2605 39 and and CC cord-005453-4057qib7 2605 40 461 461 CD cord-005453-4057qib7 2605 41 ( ( -LRB- cord-005453-4057qib7 2605 42 65 65 CD cord-005453-4057qib7 2605 43 % % NN cord-005453-4057qib7 2605 44 ) ) -RRB- cord-005453-4057qib7 2605 45 as as IN cord-005453-4057qib7 2605 46 controls control NNS cord-005453-4057qib7 2605 47 . . . cord-005453-4057qib7 2606 1 Hierarchical hierarchical JJ cord-005453-4057qib7 2606 2 linear linear JJ cord-005453-4057qib7 2606 3 regression regression NN cord-005453-4057qib7 2606 4 models model NNS cord-005453-4057qib7 2606 5 indicated indicate VBD cord-005453-4057qib7 2606 6 that that IN cord-005453-4057qib7 2606 7 after after IN cord-005453-4057qib7 2606 8 adjusting adjust VBG cord-005453-4057qib7 2606 9 for for IN cord-005453-4057qib7 2606 10 significant significant JJ cord-005453-4057qib7 2606 11 univariate univariate JJ cord-005453-4057qib7 2606 12 factors factor NNS cord-005453-4057qib7 2606 13 ( ( -LRB- cord-005453-4057qib7 2606 14 performance performance NN cord-005453-4057qib7 2606 15 status status NN cord-005453-4057qib7 2606 16 , , , cord-005453-4057qib7 2606 17 disease disease NN cord-005453-4057qib7 2606 18 status status NN cord-005453-4057qib7 2606 19 , , , cord-005453-4057qib7 2606 20 and and CC cord-005453-4057qib7 2606 21 regimen regimen NN cord-005453-4057qib7 2606 22 intensity intensity NN cord-005453-4057qib7 2606 23 ) ) -RRB- cord-005453-4057qib7 2606 24 , , , cord-005453-4057qib7 2606 25 allogeneic allogeneic IN cord-005453-4057qib7 2606 26 patients patient NNS cord-005453-4057qib7 2606 27 with with IN cord-005453-4057qib7 2606 28 treated treat VBN cord-005453-4057qib7 2606 29 depression depression NN cord-005453-4057qib7 2606 30 ( ( -LRB- cord-005453-4057qib7 2606 31 B=-2.58 B=-2.58 NNP cord-005453-4057qib7 2606 32 , , , cord-005453-4057qib7 2606 33 95 95 CD cord-005453-4057qib7 2606 34 % % NN cord-005453-4057qib7 2606 35 CI=-4.63 ci=-4.63 NN cord-005453-4057qib7 2606 36 , , , cord-005453-4057qib7 2606 37 -0.54 -0.54 CD cord-005453-4057qib7 2606 38 ) ) -RRB- cord-005453-4057qib7 2606 39 reported report VBD cord-005453-4057qib7 2606 40 better well JJR cord-005453-4057qib7 2606 41 physical physical JJ cord-005453-4057qib7 2606 42 functioning functioning NN cord-005453-4057qib7 2606 43 than than IN cord-005453-4057qib7 2606 44 patients patient NNS cord-005453-4057qib7 2606 45 with with IN cord-005453-4057qib7 2606 46 undertreated undertreated JJ cord-005453-4057qib7 2606 47 depression depression NN cord-005453-4057qib7 2606 48 ( ( -LRB- cord-005453-4057qib7 2606 49 B=-6.06 B=-6.06 NNP cord-005453-4057qib7 2606 50 , , , cord-005453-4057qib7 2606 51 95 95 CD cord-005453-4057qib7 2606 52 % % NN cord-005453-4057qib7 2606 53 CI=-9.43 CI=-9.43 NNS cord-005453-4057qib7 2606 54 , , , cord-005453-4057qib7 2606 55 -2.70 -2.70 CD cord-005453-4057qib7 2606 56 ) ) -RRB- cord-005453-4057qib7 2606 57 and and CC cord-005453-4057qib7 2606 58 untreated untreated JJ cord-005453-4057qib7 2606 59 depression depression NN cord-005453-4057qib7 2606 60 ) ) -RRB- cord-005453-4057qib7 2606 61 but but CC cord-005453-4057qib7 2606 62 worse bad JJR cord-005453-4057qib7 2606 63 physical physical JJ cord-005453-4057qib7 2606 64 functioning functioning NN cord-005453-4057qib7 2606 65 than than IN cord-005453-4057qib7 2606 66 controls control NNS cord-005453-4057qib7 2606 67 ( ( -LRB- cord-005453-4057qib7 2606 68 p p IN cord-005453-4057qib7 2606 69 values value VBZ cord-005453-4057qib7 2606 70 < < XX cord-005453-4057qib7 2606 71 0.05 0.05 CD cord-005453-4057qib7 2606 72 ) ) -RRB- cord-005453-4057qib7 2606 73 . . . cord-005453-4057qib7 2607 1 Cox Cox NNP cord-005453-4057qib7 2607 2 regression regression NN cord-005453-4057qib7 2607 3 models model NNS cord-005453-4057qib7 2607 4 indicated indicate VBD cord-005453-4057qib7 2607 5 depression depression NN cord-005453-4057qib7 2607 6 / / SYM cord-005453-4057qib7 2607 7 antidepressant antidepressant NN cord-005453-4057qib7 2607 8 usage usage NN cord-005453-4057qib7 2607 9 was be VBD cord-005453-4057qib7 2607 10 not not RB cord-005453-4057qib7 2607 11 associated associate VBN cord-005453-4057qib7 2607 12 with with IN cord-005453-4057qib7 2607 13 OS OS NNP cord-005453-4057qib7 2607 14 among among IN cord-005453-4057qib7 2607 15 allogeneic allogeneic NN cord-005453-4057qib7 2607 16 patients patient NNS cord-005453-4057qib7 2607 17 ( ( -LRB- cord-005453-4057qib7 2608 1 p p LS cord-005453-4057qib7 2608 2 values>0.10).Among values>0.10).among NN cord-005453-4057qib7 2608 3 autologous autologous JJ cord-005453-4057qib7 2608 4 patients patient NNS cord-005453-4057qib7 2608 5 , , , cord-005453-4057qib7 2608 6 195 195 CD cord-005453-4057qib7 2608 7 ( ( -LRB- cord-005453-4057qib7 2608 8 17.82 17.82 CD cord-005453-4057qib7 2608 9 % % NN cord-005453-4057qib7 2608 10 ) ) -RRB- cord-005453-4057qib7 2608 11 were be VBD cord-005453-4057qib7 2608 12 characterized characterize VBN cord-005453-4057qib7 2608 13 as as IN cord-005453-4057qib7 2608 14 having have VBG cord-005453-4057qib7 2608 15 treated treat VBN cord-005453-4057qib7 2608 16 depression depression NN cord-005453-4057qib7 2608 17 , , , cord-005453-4057qib7 2608 18 83 83 CD cord-005453-4057qib7 2608 19 ( ( -LRB- cord-005453-4057qib7 2608 20 7.59 7.59 CD cord-005453-4057qib7 2608 21 % % NN cord-005453-4057qib7 2608 22 ) ) -RRB- cord-005453-4057qib7 2608 23 as as IN cord-005453-4057qib7 2608 24 untreated untreated JJ cord-005453-4057qib7 2608 25 depression depression NN cord-005453-4057qib7 2608 26 , , , cord-005453-4057qib7 2608 27 77 77 CD cord-005453-4057qib7 2608 28 ( ( -LRB- cord-005453-4057qib7 2608 29 7.04 7.04 CD cord-005453-4057qib7 2608 30 % % NN cord-005453-4057qib7 2608 31 ) ) -RRB- cord-005453-4057qib7 2608 32 as as IN cord-005453-4057qib7 2608 33 undertreated undertreated JJ cord-005453-4057qib7 2608 34 depression depression NN cord-005453-4057qib7 2608 35 , , , cord-005453-4057qib7 2608 36 and and CC cord-005453-4057qib7 2608 37 739 739 CD cord-005453-4057qib7 2608 38 ( ( -LRB- cord-005453-4057qib7 2608 39 67.55 67.55 CD cord-005453-4057qib7 2608 40 % % NN cord-005453-4057qib7 2608 41 ) ) -RRB- cord-005453-4057qib7 2608 42 as as IN cord-005453-4057qib7 2608 43 controls control NNS cord-005453-4057qib7 2608 44 . . . cord-005453-4057qib7 2609 1 Hierarchical hierarchical JJ cord-005453-4057qib7 2609 2 linear linear JJ cord-005453-4057qib7 2609 3 regression regression NN cord-005453-4057qib7 2609 4 models model NNS cord-005453-4057qib7 2609 5 indicated indicate VBD cord-005453-4057qib7 2609 6 that that IN cord-005453-4057qib7 2609 7 after after IN cord-005453-4057qib7 2609 8 controlling control VBG cord-005453-4057qib7 2609 9 for for IN cord-005453-4057qib7 2609 10 significant significant JJ cord-005453-4057qib7 2609 11 univariate univariate JJ cord-005453-4057qib7 2609 12 factors factor NNS cord-005453-4057qib7 2609 13 ( ( -LRB- cord-005453-4057qib7 2609 14 gender gender NN cord-005453-4057qib7 2609 15 , , , cord-005453-4057qib7 2609 16 performance performance NN cord-005453-4057qib7 2609 17 status status NN cord-005453-4057qib7 2609 18 , , , cord-005453-4057qib7 2609 19 diagnosis diagnosis NN cord-005453-4057qib7 2609 20 , , , cord-005453-4057qib7 2609 21 and and CC cord-005453-4057qib7 2609 22 disease disease NN cord-005453-4057qib7 2609 23 status status NN cord-005453-4057qib7 2609 24 ) ) -RRB- cord-005453-4057qib7 2609 25 , , , cord-005453-4057qib7 2609 26 autologous autologous JJ cord-005453-4057qib7 2609 27 patients patient NNS cord-005453-4057qib7 2609 28 with with IN cord-005453-4057qib7 2609 29 treated treat VBN cord-005453-4057qib7 2609 30 depression depression NN cord-005453-4057qib7 2609 31 ( ( -LRB- cord-005453-4057qib7 2609 32 B=-2.97 B=-2.97 NNP cord-005453-4057qib7 2609 33 , , , cord-005453-4057qib7 2609 34 95 95 CD cord-005453-4057qib7 2609 35 % % NN cord-005453-4057qib7 2609 36 CI=-4.71 CI=-4.71 NNS cord-005453-4057qib7 2609 37 , , , cord-005453-4057qib7 2609 38 -1.23 -1.23 CD cord-005453-4057qib7 2609 39 ) ) -RRB- cord-005453-4057qib7 2609 40 reported report VBD cord-005453-4057qib7 2609 41 better well JJR cord-005453-4057qib7 2609 42 physical physical JJ cord-005453-4057qib7 2609 43 functioning functioning NN cord-005453-4057qib7 2609 44 than than IN cord-005453-4057qib7 2609 45 patients patient NNS cord-005453-4057qib7 2609 46 with with IN cord-005453-4057qib7 2609 47 undertreated undertreated JJ cord-005453-4057qib7 2609 48 depression depression NN cord-005453-4057qib7 2609 49 ( ( -LRB- cord-005453-4057qib7 2609 50 B=-8.63 B=-8.63 NNP cord-005453-4057qib7 2609 51 , , , cord-005453-4057qib7 2609 52 95 95 CD cord-005453-4057qib7 2609 53 % % NN cord-005453-4057qib7 2609 54 CI=-11.23 CI=-11.23 NNP cord-005453-4057qib7 2609 55 , , , cord-005453-4057qib7 2609 56 -6.03 -6.03 CD cord-005453-4057qib7 2609 57 ) ) -RRB- cord-005453-4057qib7 2609 58 and and CC cord-005453-4057qib7 2609 59 untreated untreated JJ cord-005453-4057qib7 2609 60 depression depression NN cord-005453-4057qib7 2609 61 ( ( -LRB- cord-005453-4057qib7 2609 62 B=-8.62 B=-8.62 NNP cord-005453-4057qib7 2609 63 , , , cord-005453-4057qib7 2609 64 95 95 CD cord-005453-4057qib7 2609 65 % % NN cord-005453-4057qib7 2609 66 CI=11.15 CI=11.15 NNP cord-005453-4057qib7 2609 67 , , , cord-005453-4057qib7 2609 68 -6.08 -6.08 CD cord-005453-4057qib7 2609 69 ) ) -RRB- cord-005453-4057qib7 2609 70 , , , cord-005453-4057qib7 2609 71 but but CC cord-005453-4057qib7 2609 72 worse bad JJR cord-005453-4057qib7 2609 73 physical physical JJ cord-005453-4057qib7 2609 74 functioning functioning NN cord-005453-4057qib7 2609 75 than than IN cord-005453-4057qib7 2609 76 controls control NNS cord-005453-4057qib7 2609 77 ( ( -LRB- cord-005453-4057qib7 2609 78 p p IN cord-005453-4057qib7 2609 79 values value VBZ cord-005453-4057qib7 2609 80 < < XX cord-005453-4057qib7 2609 81 0.05 0.05 CD cord-005453-4057qib7 2609 82 ) ) -RRB- cord-005453-4057qib7 2609 83 . . . cord-005453-4057qib7 2610 1 Cox Cox NNP cord-005453-4057qib7 2610 2 regression regression NN cord-005453-4057qib7 2610 3 models model NNS cord-005453-4057qib7 2610 4 showed show VBD cord-005453-4057qib7 2610 5 depression depression NN cord-005453-4057qib7 2610 6 / / SYM cord-005453-4057qib7 2610 7 antidepressant antidepressant NN cord-005453-4057qib7 2610 8 usage usage NN cord-005453-4057qib7 2610 9 was be VBD cord-005453-4057qib7 2610 10 associated associate VBN cord-005453-4057qib7 2610 11 with with IN cord-005453-4057qib7 2610 12 OS OS NNP cord-005453-4057qib7 2610 13 ( ( -LRB- cord-005453-4057qib7 2610 14 p p IN cord-005453-4057qib7 2610 15 values value NNS cord-005453-4057qib7 2610 16 < < XX cord-005453-4057qib7 2610 17 0.05 0.05 CD cord-005453-4057qib7 2610 18 ) ) -RRB- cord-005453-4057qib7 2610 19 , , , cord-005453-4057qib7 2610 20 with with IN cord-005453-4057qib7 2610 21 patients patient NNS cord-005453-4057qib7 2610 22 with with IN cord-005453-4057qib7 2610 23 treated treat VBN cord-005453-4057qib7 2610 24 depression depression NN cord-005453-4057qib7 2610 25 demonstrating demonstrate VBG cord-005453-4057qib7 2610 26 significantly significantly RB cord-005453-4057qib7 2610 27 worse bad JJR cord-005453-4057qib7 2610 28 OS os NN cord-005453-4057qib7 2610 29 than than IN cord-005453-4057qib7 2610 30 other other JJ cord-005453-4057qib7 2610 31 groups group NNS cord-005453-4057qib7 2610 32 ( ( -LRB- cord-005453-4057qib7 2610 33 p=0.05 p=0.05 JJ cord-005453-4057qib7 2610 34 ) ) -RRB- cord-005453-4057qib7 2610 35 , , , cord-005453-4057qib7 2610 36 but but CC cord-005453-4057qib7 2610 37 this this DT cord-005453-4057qib7 2610 38 association association NN cord-005453-4057qib7 2610 39 was be VBD cord-005453-4057qib7 2610 40 no no RB cord-005453-4057qib7 2610 41 longer long RBR cord-005453-4057qib7 2610 42 significant significant JJ cord-005453-4057qib7 2610 43 in in IN cord-005453-4057qib7 2610 44 multivariate multivariate JJ cord-005453-4057qib7 2610 45 analyses analysis NNS cord-005453-4057qib7 2610 46 controlling control VBG cord-005453-4057qib7 2610 47 for for IN cord-005453-4057qib7 2610 48 diagnosis diagnosis NN cord-005453-4057qib7 2610 49 and and CC cord-005453-4057qib7 2610 50 disease disease NN cord-005453-4057qib7 2610 51 status status NN cord-005453-4057qib7 2610 52 ( ( -LRB- cord-005453-4057qib7 2610 53 p=0.09 p=0.09 NN cord-005453-4057qib7 2610 54 ) ) -RRB- cord-005453-4057qib7 2610 55 . . . cord-005453-4057qib7 2611 1 Conclusions conclusion NNS cord-005453-4057qib7 2611 2 : : : cord-005453-4057qib7 2612 1 Patients patient NNS cord-005453-4057qib7 2612 2 with with IN cord-005453-4057qib7 2612 3 untreated untreated JJ cord-005453-4057qib7 2612 4 or or CC cord-005453-4057qib7 2612 5 undertreated undertreated JJ cord-005453-4057qib7 2612 6 depression depression NN cord-005453-4057qib7 2612 7 pre pre JJ cord-005453-4057qib7 2612 8 - - NN cord-005453-4057qib7 2612 9 transplant transplant NN cord-005453-4057qib7 2612 10 may may MD cord-005453-4057qib7 2612 11 benefit benefit VB cord-005453-4057qib7 2612 12 from from IN cord-005453-4057qib7 2612 13 depression depression NN cord-005453-4057qib7 2612 14 screening screening NN cord-005453-4057qib7 2612 15 and and CC cord-005453-4057qib7 2612 16 treatment treatment NN cord-005453-4057qib7 2612 17 to to TO cord-005453-4057qib7 2612 18 improve improve VB cord-005453-4057qib7 2612 19 physical physical JJ cord-005453-4057qib7 2612 20 functioning functioning NN cord-005453-4057qib7 2612 21 . . . cord-005453-4057qib7 2613 1 Disclosure disclosure NN cord-005453-4057qib7 2613 2 : : : cord-005453-4057qib7 2613 3 HSLJ HSLJ NNP cord-005453-4057qib7 2613 4 : : : cord-005453-4057qib7 2614 1 Consultant consultant NN cord-005453-4057qib7 2614 2 for for IN cord-005453-4057qib7 2614 3 RedHill RedHill NNP cord-005453-4057qib7 2614 4 Biopharma Biopharma NNP cord-005453-4057qib7 2614 5 and and CC cord-005453-4057qib7 2614 6 Janssen Janssen NNP cord-005453-4057qib7 2614 7 Scientific Scientific NNP cord-005453-4057qib7 2614 8 Affairs Affairs NNPS cord-005453-4057qib7 2614 9 P133 P133 NNP cord-005453-4057qib7 2614 10 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 2614 11 ( ( -LRB- cord-005453-4057qib7 2614 12 EPAG EPAG NNP cord-005453-4057qib7 2614 13 ) ) -RRB- cord-005453-4057qib7 2614 14 induces induce VBZ cord-005453-4057qib7 2614 15 a a DT cord-005453-4057qib7 2614 16 high high JJ cord-005453-4057qib7 2614 17 percentage percentage NN cord-005453-4057qib7 2614 18 of of IN cord-005453-4057qib7 2614 19 responses response NNS cord-005453-4057qib7 2614 20 in in IN cord-005453-4057qib7 2614 21 patients patient NNS cord-005453-4057qib7 2614 22 WITH with IN cord-005453-4057qib7 2614 23 post post FW cord-005453-4057qib7 2614 24 allo allo FW cord-005453-4057qib7 2614 25 - - HYPH cord-005453-4057qib7 2614 26 HSCT HSCT NNP cord-005453-4057qib7 2614 27 poor poor JJ cord-005453-4057qib7 2614 28 graft graft NN cord-005453-4057qib7 2614 29 function function NN cord-005453-4057qib7 2614 30 ( ( -LRB- cord-005453-4057qib7 2614 31 PGF PGF NNP cord-005453-4057qib7 2614 32 ) ) -RRB- cord-005453-4057qib7 2614 33 and and CC cord-005453-4057qib7 2614 34 no no DT cord-005453-4057qib7 2614 35 active active JJ cord-005453-4057qib7 2614 36 GVHD GVHD NNP cord-005453-4057qib7 2614 37 Lourdes Lourdes NNP cord-005453-4057qib7 2614 38 Aguirre Aguirre NNP cord-005453-4057qib7 2614 39 1 1 CD cord-005453-4057qib7 2614 40 , , , cord-005453-4057qib7 2614 41 Aitziber Aitziber NNP cord-005453-4057qib7 2614 42 Lizardi Lizardi NNP cord-005453-4057qib7 2614 43 1 1 CD cord-005453-4057qib7 2614 44 , , , cord-005453-4057qib7 2614 45 Pilar Pilar NNP cord-005453-4057qib7 2614 46 Bachiller Bachiller NNP cord-005453-4057qib7 2614 47 1 1 CD cord-005453-4057qib7 2614 48 , , , cord-005453-4057qib7 2614 49 Brigida Brigida NNP cord-005453-4057qib7 2614 50 Esteban Esteban NNP cord-005453-4057qib7 2614 51 1 1 CD cord-005453-4057qib7 2614 52 , , , cord-005453-4057qib7 2614 53 Carmen Carmen NNP cord-005453-4057qib7 2614 54 González González NNP cord-005453-4057qib7 2614 55 1 1 CD cord-005453-4057qib7 2614 56 , , , cord-005453-4057qib7 2614 57 Nagore Nagore NNP cord-005453-4057qib7 2614 58 Argoitia Argoitia NNP cord-005453-4057qib7 2614 59 1 1 CD cord-005453-4057qib7 2614 60 , , , cord-005453-4057qib7 2614 61 María María NNP cord-005453-4057qib7 2614 62 Araiz Araiz NNP cord-005453-4057qib7 2614 63 1 1 CD cord-005453-4057qib7 2614 64 , , , cord-005453-4057qib7 2614 65 Aranzazu Aranzazu NNP cord-005453-4057qib7 2614 66 Aguirre Aguirre NNP cord-005453-4057qib7 2614 67 1 1 CD cord-005453-4057qib7 2614 68 , , , cord-005453-4057qib7 2614 69 Anunciación Anunciación NNP cord-005453-4057qib7 2614 70 Urquía Urquía NNP cord-005453-4057qib7 2614 71 1 1 CD cord-005453-4057qib7 2614 72 , , , cord-005453-4057qib7 2614 73 Carlos Carlos NNP cord-005453-4057qib7 2614 74 Vallejo Vallejo NNP cord-005453-4057qib7 2614 75 1 1 CD cord-005453-4057qib7 2614 76 Background Background NNP cord-005453-4057qib7 2614 77 : : : cord-005453-4057qib7 2615 1 Persistent persistent JJ cord-005453-4057qib7 2615 2 cytopenia cytopenia NNP cord-005453-4057qib7 2615 3 is be VBZ cord-005453-4057qib7 2615 4 a a DT cord-005453-4057qib7 2615 5 life life NN cord-005453-4057qib7 2615 6 - - HYPH cord-005453-4057qib7 2615 7 threating threate VBG cord-005453-4057qib7 2615 8 complication complication NN cord-005453-4057qib7 2615 9 after after IN cord-005453-4057qib7 2615 10 HSCT HSCT NNP cord-005453-4057qib7 2615 11 . . . cord-005453-4057qib7 2616 1 Several several JJ cord-005453-4057qib7 2616 2 causes cause NNS cord-005453-4057qib7 2616 3 can can MD cord-005453-4057qib7 2616 4 lead lead VB cord-005453-4057qib7 2616 5 to to IN cord-005453-4057qib7 2616 6 this this DT cord-005453-4057qib7 2616 7 situation situation NN cord-005453-4057qib7 2616 8 ( ( -LRB- cord-005453-4057qib7 2616 9 viruses virus NNS cord-005453-4057qib7 2616 10 , , , cord-005453-4057qib7 2616 11 GVHD GVHD NNP cord-005453-4057qib7 2616 12 , , , cord-005453-4057qib7 2616 13 drugs drug NNS cord-005453-4057qib7 2616 14 , , , cord-005453-4057qib7 2616 15 etc etc FW cord-005453-4057qib7 2616 16 ) ) -RRB- cord-005453-4057qib7 2616 17 . . . cord-005453-4057qib7 2617 1 A a DT cord-005453-4057qib7 2617 2 specific specific JJ cord-005453-4057qib7 2617 3 entity entity NN cord-005453-4057qib7 2617 4 is be VBZ cord-005453-4057qib7 2617 5 the the DT cord-005453-4057qib7 2617 6 one one NN cord-005453-4057qib7 2617 7 called call VBN cord-005453-4057qib7 2617 8 " " `` cord-005453-4057qib7 2617 9 poor poor JJ cord-005453-4057qib7 2617 10 graft graft NN cord-005453-4057qib7 2617 11 function function NN cord-005453-4057qib7 2617 12 ( ( -LRB- cord-005453-4057qib7 2617 13 PGF PGF NNP cord-005453-4057qib7 2617 14 ) ) -RRB- cord-005453-4057qib7 2617 15 " " `` cord-005453-4057qib7 2617 16 , , , cord-005453-4057qib7 2617 17 which which WDT cord-005453-4057qib7 2617 18 is be VBZ cord-005453-4057qib7 2617 19 diagnosed diagnose VBN cord-005453-4057qib7 2617 20 in in IN cord-005453-4057qib7 2617 21 pts pts NN cord-005453-4057qib7 2617 22 with with IN cord-005453-4057qib7 2617 23 ≥2 ≥2 NNP cord-005453-4057qib7 2617 24 cytopenias cytopenias NNP cord-005453-4057qib7 2617 25 after after IN cord-005453-4057qib7 2617 26 day day NN cord-005453-4057qib7 2617 27 +30 +30 CD cord-005453-4057qib7 2617 28 , , , cord-005453-4057qib7 2617 29 in in IN cord-005453-4057qib7 2617 30 the the DT cord-005453-4057qib7 2617 31 presence presence NN cord-005453-4057qib7 2617 32 of of IN cord-005453-4057qib7 2617 33 donor donor NN cord-005453-4057qib7 2617 34 chimerism chimerism NN cord-005453-4057qib7 2617 35 and and CC cord-005453-4057qib7 2617 36 the the DT cord-005453-4057qib7 2617 37 absence absence NN cord-005453-4057qib7 2617 38 of of IN cord-005453-4057qib7 2617 39 GVHD GVHD NNP cord-005453-4057qib7 2617 40 or or CC cord-005453-4057qib7 2617 41 relapse relapse NN cord-005453-4057qib7 2617 42 . . . cord-005453-4057qib7 2618 1 PGF PGF NNP cord-005453-4057qib7 2618 2 is be VBZ cord-005453-4057qib7 2618 3 more more RBR cord-005453-4057qib7 2618 4 frequent frequent JJ cord-005453-4057qib7 2618 5 after after IN cord-005453-4057qib7 2618 6 alternative alternative JJ cord-005453-4057qib7 2618 7 allo allo NN cord-005453-4057qib7 2618 8 - - HYPH cord-005453-4057qib7 2618 9 HSCTs hsct NNS cord-005453-4057qib7 2618 10 , , , cord-005453-4057qib7 2618 11 such such PDT cord-005453-4057qib7 2618 12 a a DT cord-005453-4057qib7 2618 13 haplo haplo NN cord-005453-4057qib7 2618 14 - - HYPH cord-005453-4057qib7 2618 15 identical identical JJ cord-005453-4057qib7 2618 16 , , , cord-005453-4057qib7 2618 17 mismatched mismatched JJ cord-005453-4057qib7 2618 18 , , , cord-005453-4057qib7 2618 19 or or CC cord-005453-4057qib7 2618 20 UCB UCB NNP cord-005453-4057qib7 2618 21 . . . cord-005453-4057qib7 2619 1 Several several JJ cord-005453-4057qib7 2619 2 therapeutic therapeutic JJ cord-005453-4057qib7 2619 3 approaches approach NNS cord-005453-4057qib7 2619 4 for for IN cord-005453-4057qib7 2619 5 PGF PGF NNP cord-005453-4057qib7 2619 6 , , , cord-005453-4057qib7 2619 7 with with IN cord-005453-4057qib7 2619 8 poor poor JJ cord-005453-4057qib7 2619 9 results result NNS cord-005453-4057qib7 2619 10 , , , cord-005453-4057qib7 2619 11 have have VBP cord-005453-4057qib7 2619 12 been be VBN cord-005453-4057qib7 2619 13 tested test VBN cord-005453-4057qib7 2619 14 . . . cord-005453-4057qib7 2620 1 Recently recently RB cord-005453-4057qib7 2620 2 , , , cord-005453-4057qib7 2620 3 EPAG EPAG NNP cord-005453-4057qib7 2620 4 has have VBZ cord-005453-4057qib7 2620 5 been be VBN cord-005453-4057qib7 2620 6 shown show VBN cord-005453-4057qib7 2620 7 to to TO cord-005453-4057qib7 2620 8 improve improve VB cord-005453-4057qib7 2620 9 platelet platelet NN cord-005453-4057qib7 2620 10 counts count NNS cord-005453-4057qib7 2620 11 in in IN cord-005453-4057qib7 2620 12 the the DT cord-005453-4057qib7 2620 13 post post JJ cord-005453-4057qib7 2620 14 - - JJ cord-005453-4057qib7 2620 15 allo allo JJ cord-005453-4057qib7 2620 16 - - HYPH cord-005453-4057qib7 2620 17 HSCT HSCT NNP cord-005453-4057qib7 2620 18 setting setting NN cord-005453-4057qib7 2620 19 . . . cord-005453-4057qib7 2621 1 In in IN cord-005453-4057qib7 2621 2 this this DT cord-005453-4057qib7 2621 3 study study NN cord-005453-4057qib7 2621 4 , , , cord-005453-4057qib7 2621 5 we -PRON- PRP cord-005453-4057qib7 2621 6 analysed analyse VBD cord-005453-4057qib7 2621 7 the the DT cord-005453-4057qib7 2621 8 efficacy efficacy NN cord-005453-4057qib7 2621 9 of of IN cord-005453-4057qib7 2621 10 EPAG EPAG NNP cord-005453-4057qib7 2621 11 in in IN cord-005453-4057qib7 2621 12 pts pts NN cord-005453-4057qib7 2621 13 with with IN cord-005453-4057qib7 2621 14 post post JJ cord-005453-4057qib7 2621 15 - - JJ cord-005453-4057qib7 2621 16 transplant transplant JJ cord-005453-4057qib7 2621 17 persistent persistent JJ cord-005453-4057qib7 2621 18 cytopenias cytopenia NNS cord-005453-4057qib7 2621 19 . . . cord-005453-4057qib7 2622 1 Methods method NNS cord-005453-4057qib7 2622 2 : : : cord-005453-4057qib7 2623 1 The the DT cord-005453-4057qib7 2623 2 population population NN cord-005453-4057qib7 2623 3 analyzed analyze VBD cord-005453-4057qib7 2623 4 includes include VBZ cord-005453-4057qib7 2623 5 all all DT cord-005453-4057qib7 2623 6 175 175 CD cord-005453-4057qib7 2623 7 pts pt NNS cord-005453-4057qib7 2623 8 who who WP cord-005453-4057qib7 2623 9 underwent undergo VBD cord-005453-4057qib7 2623 10 allo allo NN cord-005453-4057qib7 2623 11 - - HYPH cord-005453-4057qib7 2623 12 HSCT HSCT NNP cord-005453-4057qib7 2623 13 from from IN cord-005453-4057qib7 2623 14 June June NNP cord-005453-4057qib7 2623 15 2015 2015 CD cord-005453-4057qib7 2623 16 through through IN cord-005453-4057qib7 2623 17 May May NNP cord-005453-4057qib7 2623 18 2018 2018 CD cord-005453-4057qib7 2623 19 in in IN cord-005453-4057qib7 2623 20 our -PRON- PRP$ cord-005453-4057qib7 2623 21 Unit unit NN cord-005453-4057qib7 2623 22 . . . cord-005453-4057qib7 2624 1 Median median JJ cord-005453-4057qib7 2624 2 age age NN cord-005453-4057qib7 2624 3 was be VBD cord-005453-4057qib7 2624 4 52 52 CD cord-005453-4057qib7 2624 5 years year NNS cord-005453-4057qib7 2624 6 ( ( -LRB- cord-005453-4057qib7 2624 7 12 12 CD cord-005453-4057qib7 2624 8 - - SYM cord-005453-4057qib7 2624 9 69 69 CD cord-005453-4057qib7 2624 10 ) ) -RRB- cord-005453-4057qib7 2624 11 . . . cord-005453-4057qib7 2625 1 102 102 CD cord-005453-4057qib7 2625 2 were be VBD cord-005453-4057qib7 2625 3 male male JJ cord-005453-4057qib7 2625 4 ( ( -LRB- cord-005453-4057qib7 2625 5 58.3 58.3 CD cord-005453-4057qib7 2625 6 % % NN cord-005453-4057qib7 2625 7 ) ) -RRB- cord-005453-4057qib7 2625 8 and and CC cord-005453-4057qib7 2625 9 73 73 CD cord-005453-4057qib7 2625 10 female female JJ cord-005453-4057qib7 2625 11 ( ( -LRB- cord-005453-4057qib7 2625 12 41.7 41.7 CD cord-005453-4057qib7 2625 13 % % NN cord-005453-4057qib7 2625 14 ) ) -RRB- cord-005453-4057qib7 2625 15 . . . cord-005453-4057qib7 2626 1 Baseline baseline JJ cord-005453-4057qib7 2626 2 diseases disease NNS cord-005453-4057qib7 2626 3 were be VBD cord-005453-4057qib7 2626 4 : : : cord-005453-4057qib7 2626 5 69 69 CD cord-005453-4057qib7 2626 6 AML AML NNP cord-005453-4057qib7 2626 7 , , , cord-005453-4057qib7 2626 8 39 39 CD cord-005453-4057qib7 2626 9 LPD LPD NNP cord-005453-4057qib7 2626 10 , , , cord-005453-4057qib7 2626 11 20 20 CD cord-005453-4057qib7 2626 12 ALL all DT cord-005453-4057qib7 2626 13 , , , cord-005453-4057qib7 2626 14 18 18 CD cord-005453-4057qib7 2626 15 MDS MDS NNP cord-005453-4057qib7 2626 16 , , , cord-005453-4057qib7 2626 17 15 15 CD cord-005453-4057qib7 2626 18 MPD MPD NNP cord-005453-4057qib7 2626 19 , , , cord-005453-4057qib7 2626 20 9 9 CD cord-005453-4057qib7 2626 21 MM mm NN cord-005453-4057qib7 2626 22 , , , cord-005453-4057qib7 2626 23 and and CC cord-005453-4057qib7 2626 24 5 5 CD cord-005453-4057qib7 2626 25 BMF BMF NNS cord-005453-4057qib7 2626 26 . . . cord-005453-4057qib7 2627 1 Donor donor NN cord-005453-4057qib7 2627 2 was be VBD cord-005453-4057qib7 2627 3 unrelated unrelated JJ cord-005453-4057qib7 2627 4 in in IN cord-005453-4057qib7 2627 5 101 101 CD cord-005453-4057qib7 2627 6 ( ( -LRB- cord-005453-4057qib7 2627 7 54.3 54.3 CD cord-005453-4057qib7 2627 8 % % NN cord-005453-4057qib7 2627 9 ) ) -RRB- cord-005453-4057qib7 2627 10 and and CC cord-005453-4057qib7 2627 11 was be VBD cord-005453-4057qib7 2627 12 family family NN cord-005453-4057qib7 2627 13 in in IN cord-005453-4057qib7 2627 14 74 74 CD cord-005453-4057qib7 2627 15 ( ( -LRB- cord-005453-4057qib7 2627 16 42.3 42.3 CD cord-005453-4057qib7 2627 17 % % NN cord-005453-4057qib7 2627 18 ) ) -RRB- cord-005453-4057qib7 2627 19 ( ( -LRB- cord-005453-4057qib7 2627 20 including include VBG cord-005453-4057qib7 2627 21 25 25 CD cord-005453-4057qib7 2627 22 haplo haplo NN cord-005453-4057qib7 2627 23 - - HYPH cord-005453-4057qib7 2627 24 identical identical JJ cord-005453-4057qib7 2627 25 ) ) -RRB- cord-005453-4057qib7 2627 26 . . . cord-005453-4057qib7 2628 1 Conditioning conditioning NN cord-005453-4057qib7 2628 2 was be VBD cord-005453-4057qib7 2628 3 RIC RIC NNP cord-005453-4057qib7 2628 4 in in IN cord-005453-4057qib7 2628 5 95 95 CD cord-005453-4057qib7 2628 6 ( ( -LRB- cord-005453-4057qib7 2628 7 54.3 54.3 CD cord-005453-4057qib7 2628 8 % % NN cord-005453-4057qib7 2628 9 ) ) -RRB- cord-005453-4057qib7 2628 10 and and CC cord-005453-4057qib7 2628 11 intensive intensive JJ cord-005453-4057qib7 2628 12 in in IN cord-005453-4057qib7 2628 13 80 80 CD cord-005453-4057qib7 2628 14 ( ( -LRB- cord-005453-4057qib7 2628 15 45.7 45.7 CD cord-005453-4057qib7 2628 16 % % NN cord-005453-4057qib7 2628 17 ) ) -RRB- cord-005453-4057qib7 2628 18 . . . cord-005453-4057qib7 2629 1 SC SC NNP cord-005453-4057qib7 2629 2 source source NN cord-005453-4057qib7 2629 3 was be VBD cord-005453-4057qib7 2629 4 PB PB NNP cord-005453-4057qib7 2629 5 in in IN cord-005453-4057qib7 2629 6 164 164 CD cord-005453-4057qib7 2629 7 ( ( -LRB- cord-005453-4057qib7 2629 8 93.7 93.7 CD cord-005453-4057qib7 2629 9 % % NN cord-005453-4057qib7 2629 10 ) ) -RRB- cord-005453-4057qib7 2629 11 and and CC cord-005453-4057qib7 2629 12 BM BM NNP cord-005453-4057qib7 2629 13 in in IN cord-005453-4057qib7 2629 14 11 11 CD cord-005453-4057qib7 2629 15 ( ( -LRB- cord-005453-4057qib7 2629 16 6.3 6.3 CD cord-005453-4057qib7 2629 17 % % NN cord-005453-4057qib7 2629 18 ) ) -RRB- cord-005453-4057qib7 2629 19 . . . cord-005453-4057qib7 2630 1 Median median JJ cord-005453-4057qib7 2630 2 followup followup NN cord-005453-4057qib7 2630 3 was be VBD cord-005453-4057qib7 2630 4 24 24 CD cord-005453-4057qib7 2630 5 months month NNS cord-005453-4057qib7 2630 6 ( ( -LRB- cord-005453-4057qib7 2630 7 6 6 CD cord-005453-4057qib7 2630 8 - - SYM cord-005453-4057qib7 2630 9 41 41 CD cord-005453-4057qib7 2630 10 ) ) -RRB- cord-005453-4057qib7 2630 11 . . . cord-005453-4057qib7 2631 1 EPAG EPAG NNP cord-005453-4057qib7 2631 2 was be VBD cord-005453-4057qib7 2631 3 initiated initiate VBN cord-005453-4057qib7 2631 4 at at IN cord-005453-4057qib7 2631 5 some some DT cord-005453-4057qib7 2631 6 point point NN cord-005453-4057qib7 2631 7 during during IN cord-005453-4057qib7 2631 8 the the DT cord-005453-4057qib7 2631 9 first first JJ cord-005453-4057qib7 2631 10 6-month 6-month CD cord-005453-4057qib7 2631 11 post post JJ cord-005453-4057qib7 2631 12 - - JJ cord-005453-4057qib7 2631 13 HSCT hsct JJ cord-005453-4057qib7 2631 14 period period NN cord-005453-4057qib7 2631 15 in in IN cord-005453-4057qib7 2631 16 12 12 CD cord-005453-4057qib7 2631 17 pts pt NNS cord-005453-4057qib7 2631 18 ( ( -LRB- cord-005453-4057qib7 2631 19 6.9 6.9 CD cord-005453-4057qib7 2631 20 % % NN cord-005453-4057qib7 2631 21 of of IN cord-005453-4057qib7 2631 22 the the DT cord-005453-4057qib7 2631 23 series series NN cord-005453-4057qib7 2631 24 ) ) -RRB- cord-005453-4057qib7 2631 25 due due JJ cord-005453-4057qib7 2631 26 to to IN cord-005453-4057qib7 2631 27 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2631 28 ( ( -LRB- cord-005453-4057qib7 2631 29 < < XX cord-005453-4057qib7 2631 30 20000 20000 CD cord-005453-4057qib7 2631 31 / / SYM cord-005453-4057qib7 2631 32 mcL mcl NN cord-005453-4057qib7 2631 33 ) ) -RRB- cord-005453-4057qib7 2631 34 plus plus CC cord-005453-4057qib7 2631 35 , , , cord-005453-4057qib7 2631 36 at at IN cord-005453-4057qib7 2631 37 least least JJS cord-005453-4057qib7 2631 38 , , , cord-005453-4057qib7 2631 39 one one CD cord-005453-4057qib7 2631 40 other other JJ cord-005453-4057qib7 2631 41 cytopenia cytopenia NNS cord-005453-4057qib7 2631 42 . . . cord-005453-4057qib7 2632 1 Patients patient NNS cord-005453-4057qib7 2632 2 characteristics characteristic NNS cord-005453-4057qib7 2632 3 shown show VBN cord-005453-4057qib7 2632 4 in in IN cord-005453-4057qib7 2632 5 table table NN cord-005453-4057qib7 2632 6 1 1 CD cord-005453-4057qib7 2632 7 . . . cord-005453-4057qib7 2633 1 EPAG EPAG NNP cord-005453-4057qib7 2633 2 was be VBD cord-005453-4057qib7 2633 3 started start VBN cord-005453-4057qib7 2633 4 at at IN cord-005453-4057qib7 2633 5 50 50 CD cord-005453-4057qib7 2633 6 mg mg NNP cord-005453-4057qib7 2633 7 / / SYM cord-005453-4057qib7 2633 8 day day NN cord-005453-4057qib7 2633 9 and and CC cord-005453-4057qib7 2633 10 escalated escalate VBD cord-005453-4057qib7 2633 11 each each DT cord-005453-4057qib7 2633 12 2 2 CD cord-005453-4057qib7 2633 13 weeks week NNS cord-005453-4057qib7 2633 14 to to IN cord-005453-4057qib7 2633 15 75 75 CD cord-005453-4057qib7 2633 16 , , , cord-005453-4057qib7 2633 17 125 125 CD cord-005453-4057qib7 2633 18 and and CC cord-005453-4057qib7 2633 19 150 150 CD cord-005453-4057qib7 2633 20 mg mg NNP cord-005453-4057qib7 2633 21 / / SYM cord-005453-4057qib7 2633 22 day day NN cord-005453-4057qib7 2633 23 if if IN cord-005453-4057qib7 2633 24 platelet platelet NN cord-005453-4057qib7 2633 25 count count NN cord-005453-4057qib7 2633 26 was be VBD cord-005453-4057qib7 2633 27 < < XX cord-005453-4057qib7 2633 28 20000 20000 CD cord-005453-4057qib7 2633 29 / / SYM cord-005453-4057qib7 2633 30 mcL. mcl. NN cord-005453-4057qib7 2633 31 Global global JJ cord-005453-4057qib7 2633 32 response response NN cord-005453-4057qib7 2633 33 was be VBD cord-005453-4057qib7 2633 34 considered consider VBN cord-005453-4057qib7 2633 35 when when WRB cord-005453-4057qib7 2633 36 , , , cord-005453-4057qib7 2633 37 after after IN cord-005453-4057qib7 2633 38 EPAG EPAG NNP cord-005453-4057qib7 2633 39 , , , cord-005453-4057qib7 2633 40 the the DT cord-005453-4057qib7 2633 41 patient patient NN cord-005453-4057qib7 2633 42 needed need VBD cord-005453-4057qib7 2633 43 no no DT cord-005453-4057qib7 2633 44 transfusions transfusion NNS cord-005453-4057qib7 2633 45 and and CC cord-005453-4057qib7 2633 46 reached reach VBD cord-005453-4057qib7 2633 47 the the DT cord-005453-4057qib7 2633 48 three three CD cord-005453-4057qib7 2633 49 of of IN cord-005453-4057qib7 2633 50 the the DT cord-005453-4057qib7 2633 51 following follow VBG cord-005453-4057qib7 2633 52 : : : cord-005453-4057qib7 2633 53 platelets platelet NNS cord-005453-4057qib7 2633 54 > > NFP cord-005453-4057qib7 2633 55 50000 50000 CD cord-005453-4057qib7 2633 56 / / SYM cord-005453-4057qib7 2633 57 mcL mcl NN cord-005453-4057qib7 2633 58 , , , cord-005453-4057qib7 2633 59 Hgb Hgb NNP cord-005453-4057qib7 2634 1 > > XX cord-005453-4057qib7 2635 1 10 10 CD cord-005453-4057qib7 2635 2 g g NN cord-005453-4057qib7 2635 3 / / SYM cord-005453-4057qib7 2635 4 dL dl NN cord-005453-4057qib7 2635 5 , , , cord-005453-4057qib7 2635 6 and and CC cord-005453-4057qib7 2635 7 ANC ANC NNP cord-005453-4057qib7 2635 8 > > XX cord-005453-4057qib7 2636 1 1000 1000 CD cord-005453-4057qib7 2636 2 / / SYM cord-005453-4057qib7 2636 3 mcL. mcl. NN cord-005453-4057qib7 2636 4 EPAG EPAG NNP cord-005453-4057qib7 2636 5 was be VBD cord-005453-4057qib7 2636 6 tapered taper VBN cord-005453-4057qib7 2636 7 off off RP cord-005453-4057qib7 2636 8 in in IN cord-005453-4057qib7 2636 9 responders responder NNS cord-005453-4057qib7 2636 10 and and CC cord-005453-4057qib7 2636 11 discontinued discontinue VBD cord-005453-4057qib7 2636 12 if if IN cord-005453-4057qib7 2636 13 no no DT cord-005453-4057qib7 2636 14 response response NN cord-005453-4057qib7 2636 15 was be VBD cord-005453-4057qib7 2636 16 reached reach VBN cord-005453-4057qib7 2636 17 after after IN cord-005453-4057qib7 2636 18 16 16 CD cord-005453-4057qib7 2636 19 weeks week NNS cord-005453-4057qib7 2636 20 . . . cord-005453-4057qib7 2637 1 Results result NNS cord-005453-4057qib7 2637 2 : : : cord-005453-4057qib7 2638 1 At at IN cord-005453-4057qib7 2638 2 EPAG EPAG NNP cord-005453-4057qib7 2638 3 initiation initiation NN cord-005453-4057qib7 2638 4 , , , cord-005453-4057qib7 2638 5 all all PDT cord-005453-4057qib7 2638 6 the the DT cord-005453-4057qib7 2638 7 12 12 CD cord-005453-4057qib7 2638 8 pts pt NNS cord-005453-4057qib7 2638 9 had have VBD cord-005453-4057qib7 2638 10 thrombocytopenia thrombocytopenia VBN cord-005453-4057qib7 2638 11 ( ( -LRB- cord-005453-4057qib7 2638 12 < < XX cord-005453-4057qib7 2638 13 20000 20000 CD cord-005453-4057qib7 2638 14 / / SYM cord-005453-4057qib7 2638 15 mcL mcl NN cord-005453-4057qib7 2638 16 ) ) -RRB- cord-005453-4057qib7 2638 17 , , , cord-005453-4057qib7 2638 18 10 10 CD cord-005453-4057qib7 2638 19 had have VBD cord-005453-4057qib7 2638 20 anemia anemia NN cord-005453-4057qib7 2638 21 ( ( -LRB- cord-005453-4057qib7 2638 22 Hgb Hgb NNP cord-005453-4057qib7 2638 23 < < XX cord-005453-4057qib7 2638 24 10 10 CD cord-005453-4057qib7 2638 25 g g NN cord-005453-4057qib7 2638 26 / / SYM cord-005453-4057qib7 2638 27 dL dl NN cord-005453-4057qib7 2638 28 ) ) -RRB- cord-005453-4057qib7 2638 29 , , , cord-005453-4057qib7 2638 30 and and CC cord-005453-4057qib7 2638 31 5 5 CD cord-005453-4057qib7 2638 32 had have VBD cord-005453-4057qib7 2638 33 neutropenia neutropenia VBN cord-005453-4057qib7 2639 1 ( ( -LRB- cord-005453-4057qib7 2639 2 ANC ANC NNP cord-005453-4057qib7 2639 3 < < XX cord-005453-4057qib7 2639 4 1000 1000 CD cord-005453-4057qib7 2639 5 / / SYM cord-005453-4057qib7 2639 6 mcL mcl NN cord-005453-4057qib7 2639 7 ) ) -RRB- cord-005453-4057qib7 2639 8 . . . cord-005453-4057qib7 2640 1 Counts count NNS cord-005453-4057qib7 2640 2 pre pre VBP cord-005453-4057qib7 2640 3 and and CC cord-005453-4057qib7 2640 4 post post VB cord-005453-4057qib7 2640 5 and and CC cord-005453-4057qib7 2640 6 response response NN cord-005453-4057qib7 2640 7 to to IN cord-005453-4057qib7 2640 8 EPAG EPAG NNP cord-005453-4057qib7 2640 9 are be VBP cord-005453-4057qib7 2640 10 shown show VBN cord-005453-4057qib7 2640 11 in in IN cord-005453-4057qib7 2640 12 table table NN cord-005453-4057qib7 2640 13 2 2 CD cord-005453-4057qib7 2640 14 . . . cord-005453-4057qib7 2641 1 Among among IN cord-005453-4057qib7 2641 2 the the DT cord-005453-4057qib7 2641 3 8 8 CD cord-005453-4057qib7 2641 4 responders responder NNS cord-005453-4057qib7 2641 5 , , , cord-005453-4057qib7 2641 6 all all DT cord-005453-4057qib7 2641 7 but but IN cord-005453-4057qib7 2641 8 one one NN cord-005453-4057qib7 2641 9 ( ( -LRB- cord-005453-4057qib7 2641 10 who who WP cord-005453-4057qib7 2641 11 relapsed relapse VBD cord-005453-4057qib7 2641 12 from from IN cord-005453-4057qib7 2641 13 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2641 14 and and CC cord-005453-4057qib7 2641 15 died die VBD cord-005453-4057qib7 2641 16 from from IN cord-005453-4057qib7 2641 17 bleeding bleed VBG cord-005453-4057qib7 2641 18 ) ) -RRB- cord-005453-4057qib7 2641 19 were be VBD cord-005453-4057qib7 2641 20 alive alive JJ cord-005453-4057qib7 2641 21 at at IN cord-005453-4057qib7 2641 22 analysis analysis NN cord-005453-4057qib7 2641 23 close close NN cord-005453-4057qib7 2641 24 ( ( -LRB- cord-005453-4057qib7 2641 25 87.5 87.5 CD cord-005453-4057qib7 2641 26 % % NN cord-005453-4057qib7 2641 27 ) ) -RRB- cord-005453-4057qib7 2641 28 . . . cord-005453-4057qib7 2642 1 Among among IN cord-005453-4057qib7 2642 2 the the DT cord-005453-4057qib7 2642 3 4 4 CD cord-005453-4057qib7 2642 4 non non NNS cord-005453-4057qib7 2642 5 - - NNS cord-005453-4057qib7 2642 6 responders responder NNS cord-005453-4057qib7 2642 7 , , , cord-005453-4057qib7 2642 8 three three CD cord-005453-4057qib7 2642 9 pts pt NNS cord-005453-4057qib7 2642 10 had have VBD cord-005453-4057qib7 2642 11 GVHD GVHD NNP cord-005453-4057qib7 2642 12 - - HYPH cord-005453-4057qib7 2642 13 associated associate VBN cord-005453-4057qib7 2642 14 cytopenias cytopenia NNS cord-005453-4057qib7 2642 15 , , , cord-005453-4057qib7 2642 16 and and CC cord-005453-4057qib7 2642 17 finally finally RB cord-005453-4057qib7 2642 18 died die VBD cord-005453-4057qib7 2642 19 from from IN cord-005453-4057qib7 2642 20 infectious infectious JJ cord-005453-4057qib7 2642 21 complications complication NNS cord-005453-4057qib7 2642 22 ; ; : cord-005453-4057qib7 2642 23 the the DT cord-005453-4057qib7 2642 24 other other JJ cord-005453-4057qib7 2642 25 patient patient NN cord-005453-4057qib7 2642 26 relapsed relapse VBD cord-005453-4057qib7 2642 27 from from IN cord-005453-4057qib7 2642 28 her -PRON- PRP$ cord-005453-4057qib7 2642 29 AML AML NNP cord-005453-4057qib7 2642 30 , , , cord-005453-4057qib7 2642 31 reached reach VBD cord-005453-4057qib7 2642 32 a a DT cord-005453-4057qib7 2642 33 new new JJ cord-005453-4057qib7 2642 34 CR cr NN cord-005453-4057qib7 2642 35 after after IN cord-005453-4057qib7 2642 36 treatment treatment NN cord-005453-4057qib7 2642 37 , , , cord-005453-4057qib7 2642 38 and and CC cord-005453-4057qib7 2642 39 is be VBZ cord-005453-4057qib7 2642 40 alive alive JJ cord-005453-4057qib7 2642 41 and and CC cord-005453-4057qib7 2642 42 well well RB cord-005453-4057qib7 2642 43 27 27 CD cord-005453-4057qib7 2642 44 months month NNS cord-005453-4057qib7 2642 45 afterwards afterwards RB cord-005453-4057qib7 2642 46 . . . cord-005453-4057qib7 2643 1 EPAG EPAG NNP cord-005453-4057qib7 2643 2 was be VBD cord-005453-4057qib7 2643 3 tapered taper VBN cord-005453-4057qib7 2643 4 off off RP cord-005453-4057qib7 2643 5 and and CC cord-005453-4057qib7 2643 6 discontinued discontinue VBD cord-005453-4057qib7 2643 7 in in IN cord-005453-4057qib7 2643 8 6/8 6/8 CD cord-005453-4057qib7 2643 9 pts pt NNS cord-005453-4057qib7 2643 10 who who WP cord-005453-4057qib7 2643 11 responded respond VBD cord-005453-4057qib7 2643 12 ; ; : cord-005453-4057qib7 2643 13 2/8 2/8 CD cord-005453-4057qib7 2643 14 responders responder NNS cord-005453-4057qib7 2643 15 are be VBP cord-005453-4057qib7 2643 16 still still RB cord-005453-4057qib7 2643 17 on on IN cord-005453-4057qib7 2643 18 EPAG EPAG NNP cord-005453-4057qib7 2643 19 . . . cord-005453-4057qib7 2644 1 EPAG EPAG NNP cord-005453-4057qib7 2644 2 was be VBD cord-005453-4057qib7 2644 3 discontinued discontinue VBN cord-005453-4057qib7 2644 4 in in IN cord-005453-4057qib7 2644 5 the the DT cord-005453-4057qib7 2644 6 4/4 4/4 CD cord-005453-4057qib7 2644 7 pts pts NN cord-005453-4057qib7 2644 8 who who WP cord-005453-4057qib7 2644 9 did do VBD cord-005453-4057qib7 2644 10 not not RB cord-005453-4057qib7 2644 11 respond respond VB cord-005453-4057qib7 2644 12 . . . cord-005453-4057qib7 2645 1 Rest rest NN cord-005453-4057qib7 2645 2 of of IN cord-005453-4057qib7 2645 3 treatment treatment NN cord-005453-4057qib7 2645 4 details detail NNS cord-005453-4057qib7 2645 5 shown show VBN cord-005453-4057qib7 2645 6 in in IN cord-005453-4057qib7 2645 7 table table NN cord-005453-4057qib7 2645 8 2 2 CD cord-005453-4057qib7 2645 9 . . . cord-005453-4057qib7 2646 1 Conclusions conclusion NNS cord-005453-4057qib7 2646 2 : : : cord-005453-4057qib7 2646 3 1 1 LS cord-005453-4057qib7 2646 4 ) ) -RRB- cord-005453-4057qib7 2647 1 EPAG EPAG NNP cord-005453-4057qib7 2647 2 worked work VBD cord-005453-4057qib7 2647 3 striking strike VBG cord-005453-4057qib7 2647 4 well well RB cord-005453-4057qib7 2647 5 in in IN cord-005453-4057qib7 2647 6 subjects subject NNS cord-005453-4057qib7 2647 7 with with IN cord-005453-4057qib7 2647 8 PGF PGF NNP cord-005453-4057qib7 2647 9 , , , cord-005453-4057qib7 2647 10 an an DT cord-005453-4057qib7 2647 11 otherwise otherwise RB cord-005453-4057qib7 2647 12 a a DT cord-005453-4057qib7 2647 13 life life NN cord-005453-4057qib7 2647 14 - - HYPH cord-005453-4057qib7 2647 15 threatening threaten VBG cord-005453-4057qib7 2647 16 situation situation NN cord-005453-4057qib7 2647 17 for for IN cord-005453-4057qib7 2647 18 patients patient NNS cord-005453-4057qib7 2647 19 . . . cord-005453-4057qib7 2648 1 2 2 LS cord-005453-4057qib7 2648 2 ) ) -RRB- cord-005453-4057qib7 2648 3 EPAG EPAG NNP cord-005453-4057qib7 2648 4 induced induce VBD cord-005453-4057qib7 2648 5 impressive impressive JJ cord-005453-4057qib7 2648 6 responses response NNS cord-005453-4057qib7 2648 7 in in IN cord-005453-4057qib7 2648 8 platelets platelet NNS cord-005453-4057qib7 2648 9 , , , cord-005453-4057qib7 2648 10 but but CC cord-005453-4057qib7 2648 11 strong strong JJ cord-005453-4057qib7 2648 12 bilinear bilinear JJ cord-005453-4057qib7 2648 13 and and CC cord-005453-4057qib7 2648 14 trilinear trilinear JJ cord-005453-4057qib7 2648 15 responses response NNS cord-005453-4057qib7 2648 16 were be VBD cord-005453-4057qib7 2648 17 also also RB cord-005453-4057qib7 2648 18 seen see VBN cord-005453-4057qib7 2648 19 . . . cord-005453-4057qib7 2649 1 3 3 LS cord-005453-4057qib7 2649 2 ) ) -RRB- cord-005453-4057qib7 2649 3 EPAG EPAG NNP cord-005453-4057qib7 2649 4 did do VBD cord-005453-4057qib7 2649 5 not not RB cord-005453-4057qib7 2649 6 improve improve VB cord-005453-4057qib7 2649 7 GVHD GVHD NNP cord-005453-4057qib7 2649 8 - - HYPH cord-005453-4057qib7 2649 9 associated associate VBN cord-005453-4057qib7 2649 10 cytopenias cytopenia NNS cord-005453-4057qib7 2649 11 . . . cord-005453-4057qib7 2650 1 4 4 LS cord-005453-4057qib7 2650 2 ) ) -RRB- cord-005453-4057qib7 2651 1 To to TO cord-005453-4057qib7 2651 2 confirm confirm VB cord-005453-4057qib7 2651 3 these these DT cord-005453-4057qib7 2651 4 innovative innovative JJ cord-005453-4057qib7 2651 5 and and CC cord-005453-4057qib7 2651 6 transcendent transcendent JJ cord-005453-4057qib7 2651 7 results result NNS cord-005453-4057qib7 2651 8 , , , cord-005453-4057qib7 2651 9 we -PRON- PRP cord-005453-4057qib7 2651 10 have have VBP cord-005453-4057qib7 2651 11 just just RB cord-005453-4057qib7 2651 12 initiated initiate VBN cord-005453-4057qib7 2651 13 a a DT cord-005453-4057qib7 2651 14 multicenter multicenter JJ cord-005453-4057qib7 2651 15 prospective prospective JJ cord-005453-4057qib7 2651 16 study study NN cord-005453-4057qib7 2651 17 on on IN cord-005453-4057qib7 2651 18 the the DT cord-005453-4057qib7 2651 19 role role NN cord-005453-4057qib7 2651 20 of of IN cord-005453-4057qib7 2651 21 EPAG EPAG NNP cord-005453-4057qib7 2651 22 for for IN cord-005453-4057qib7 2651 23 treatment treatment NN cord-005453-4057qib7 2651 24 of of IN cord-005453-4057qib7 2651 25 post post JJ cord-005453-4057qib7 2651 26 - - JJ cord-005453-4057qib7 2651 27 HSCT HSCT NNP cord-005453-4057qib7 2651 28 PGF PGF NNP cord-005453-4057qib7 2651 29 . . . cord-005453-4057qib7 2652 1 1232 1232 CD cord-005453-4057qib7 2653 1 * * NFP cord-005453-4057qib7 2653 2 Five five CD cord-005453-4057qib7 2653 3 out out IN cord-005453-4057qib7 2653 4 of of IN cord-005453-4057qib7 2653 5 the the DT cord-005453-4057qib7 2653 6 six six CD cord-005453-4057qib7 2653 7 URDT URDT NNP cord-005453-4057qib7 2653 8 were be VBD cord-005453-4057qib7 2653 9 mismatched mismatch VBN cord-005453-4057qib7 2654 1 * * NFP cord-005453-4057qib7 2654 2 * * NFP cord-005453-4057qib7 2654 3 The the DT cord-005453-4057qib7 2654 4 donor donor NN cord-005453-4057qib7 2654 5 was be VBD cord-005453-4057qib7 2654 6 a a DT cord-005453-4057qib7 2654 7 woman woman NN cord-005453-4057qib7 2654 8 in in IN cord-005453-4057qib7 2654 9 the the DT cord-005453-4057qib7 2654 10 six six CD cord-005453-4057qib7 2654 11 cases case NNS cord-005453-4057qib7 2654 12 : : : cord-005453-4057qib7 2654 13 three three CD cord-005453-4057qib7 2654 14 sisters sister NNS cord-005453-4057qib7 2654 15 and and CC cord-005453-4057qib7 2654 16 three three CD cord-005453-4057qib7 2654 17 daughters daughter NNS cord-005453-4057qib7 2655 1 Background background NN cord-005453-4057qib7 2655 2 : : : cord-005453-4057qib7 2655 3 Hepatic hepatic JJ cord-005453-4057qib7 2655 4 VOD VOD NNP cord-005453-4057qib7 2655 5 / / SYM cord-005453-4057qib7 2655 6 SOS SOS NNP cord-005453-4057qib7 2655 7 with with IN cord-005453-4057qib7 2655 8 multi multi JJ cord-005453-4057qib7 2655 9 - - JJ cord-005453-4057qib7 2655 10 organ organ JJ cord-005453-4057qib7 2655 11 dysfunction dysfunction NN cord-005453-4057qib7 2655 12 ( ( -LRB- cord-005453-4057qib7 2655 13 MOD mod NN cord-005453-4057qib7 2655 14 ; ; : cord-005453-4057qib7 2655 15 typically typically RB cord-005453-4057qib7 2655 16 , , , cord-005453-4057qib7 2655 17 renal renal JJ cord-005453-4057qib7 2655 18 or or CC cord-005453-4057qib7 2655 19 pulmonary pulmonary JJ cord-005453-4057qib7 2655 20 ) ) -RRB- cord-005453-4057qib7 2655 21 may may MD cord-005453-4057qib7 2655 22 be be VB cord-005453-4057qib7 2655 23 associated associate VBN cord-005453-4057qib7 2655 24 with with IN cord-005453-4057qib7 2655 25 > > XX cord-005453-4057qib7 2655 26 80 80 CD cord-005453-4057qib7 2655 27 % % NN cord-005453-4057qib7 2655 28 mortality mortality NN cord-005453-4057qib7 2655 29 . . . cord-005453-4057qib7 2656 1 Defibrotide Defibrotide NNP cord-005453-4057qib7 2656 2 is be VBZ cord-005453-4057qib7 2656 3 approved approve VBN cord-005453-4057qib7 2656 4 for for IN cord-005453-4057qib7 2656 5 treating treat VBG cord-005453-4057qib7 2656 6 severe severe JJ cord-005453-4057qib7 2656 7 hepatic hepatic JJ cord-005453-4057qib7 2656 8 VOD VOD NNP cord-005453-4057qib7 2656 9 / / SYM cord-005453-4057qib7 2656 10 SOS SOS NNP cord-005453-4057qib7 2656 11 post post NNP cord-005453-4057qib7 2656 12 - - JJ cord-005453-4057qib7 2656 13 HSCT HSCT NNP cord-005453-4057qib7 2656 14 in in IN cord-005453-4057qib7 2656 15 patients patient NNS cord-005453-4057qib7 2656 16 aged age VBN cord-005453-4057qib7 2656 17 > > SYM cord-005453-4057qib7 2656 18 1 1 CD cord-005453-4057qib7 2656 19 month month NN cord-005453-4057qib7 2656 20 in in IN cord-005453-4057qib7 2656 21 the the DT cord-005453-4057qib7 2656 22 EU EU NNP cord-005453-4057qib7 2656 23 , , , cord-005453-4057qib7 2656 24 and and CC cord-005453-4057qib7 2656 25 for for IN cord-005453-4057qib7 2656 26 hepatic hepatic JJ cord-005453-4057qib7 2656 27 VOD VOD NNP cord-005453-4057qib7 2656 28 / / SYM cord-005453-4057qib7 2656 29 SOS SOS NNP cord-005453-4057qib7 2656 30 with with IN cord-005453-4057qib7 2656 31 renal renal JJ cord-005453-4057qib7 2656 32 or or CC cord-005453-4057qib7 2656 33 pulmonary pulmonary JJ cord-005453-4057qib7 2656 34 dysfunction dysfunction NN cord-005453-4057qib7 2656 35 post post NN cord-005453-4057qib7 2656 36 - - JJ cord-005453-4057qib7 2656 37 HSCT HSCT NNP cord-005453-4057qib7 2656 38 in in IN cord-005453-4057qib7 2656 39 the the DT cord-005453-4057qib7 2656 40 US US NNP cord-005453-4057qib7 2656 41 . . . cord-005453-4057qib7 2657 1 This this DT cord-005453-4057qib7 2657 2 analysis analysis NN cord-005453-4057qib7 2657 3 provides provide VBZ cord-005453-4057qib7 2657 4 an an DT cord-005453-4057qib7 2657 5 overview overview NN cord-005453-4057qib7 2657 6 of of IN cord-005453-4057qib7 2657 7 the the DT cord-005453-4057qib7 2657 8 safety safety NN cord-005453-4057qib7 2657 9 results result NNS cord-005453-4057qib7 2657 10 from from IN cord-005453-4057qib7 2657 11 3 3 CD cord-005453-4057qib7 2657 12 studies study NNS cord-005453-4057qib7 2657 13 of of IN cord-005453-4057qib7 2657 14 patients patient NNS cord-005453-4057qib7 2657 15 with with IN cord-005453-4057qib7 2657 16 VOD VOD NNP cord-005453-4057qib7 2657 17 / / SYM cord-005453-4057qib7 2657 18 SOS SOS NNP cord-005453-4057qib7 2657 19 , , , cord-005453-4057qib7 2657 20 with with IN cord-005453-4057qib7 2657 21 or or CC cord-005453-4057qib7 2657 22 without without IN cord-005453-4057qib7 2657 23 MOD mod NN cord-005453-4057qib7 2657 24 , , , cord-005453-4057qib7 2657 25 who who WP cord-005453-4057qib7 2657 26 received receive VBD cord-005453-4057qib7 2657 27 defibrotide defibrotide NNP cord-005453-4057qib7 2657 28 25 25 CD cord-005453-4057qib7 2657 29 mg mg NNP cord-005453-4057qib7 2657 30 / / SYM cord-005453-4057qib7 2657 31 kg kg NNP cord-005453-4057qib7 2657 32 / / SYM cord-005453-4057qib7 2657 33 day day NN cord-005453-4057qib7 2657 34 . . . cord-005453-4057qib7 2658 1 Methods method NNS cord-005453-4057qib7 2658 2 : : : cord-005453-4057qib7 2658 3 Safety safety NN cord-005453-4057qib7 2658 4 data datum NNS cord-005453-4057qib7 2658 5 were be VBD cord-005453-4057qib7 2658 6 pooled pool VBN cord-005453-4057qib7 2658 7 from from IN cord-005453-4057qib7 2658 8 patients patient NNS cord-005453-4057qib7 2658 9 with with IN cord-005453-4057qib7 2658 10 VOD VOD NNP cord-005453-4057qib7 2658 11 / / SYM cord-005453-4057qib7 2658 12 SOS SOS NNP cord-005453-4057qib7 2658 13 post post NNP cord-005453-4057qib7 2658 14 - - JJ cord-005453-4057qib7 2658 15 HSCT HSCT NNP cord-005453-4057qib7 2658 16 treated treat VBN cord-005453-4057qib7 2658 17 with with IN cord-005453-4057qib7 2658 18 defibrotide defibrotide NN cord-005453-4057qib7 2658 19 in in IN cord-005453-4057qib7 2658 20 a a DT cord-005453-4057qib7 2658 21 phase phase NN cord-005453-4057qib7 2658 22 3 3 CD cord-005453-4057qib7 2658 23 trial trial NN cord-005453-4057qib7 2658 24 ( ( -LRB- cord-005453-4057qib7 2658 25 n=102 n=102 NNP cord-005453-4057qib7 2658 26 ) ) -RRB- cord-005453-4057qib7 2658 27 and and CC cord-005453-4057qib7 2658 28 a a DT cord-005453-4057qib7 2658 29 phase phase NN cord-005453-4057qib7 2658 30 2 2 CD cord-005453-4057qib7 2658 31 , , , cord-005453-4057qib7 2658 32 randomized randomized JJ cord-005453-4057qib7 2658 33 dose dose NN cord-005453-4057qib7 2658 34 - - HYPH cord-005453-4057qib7 2658 35 finding find VBG cord-005453-4057qib7 2658 36 trial trial NN cord-005453-4057qib7 2658 37 ( ( -LRB- cord-005453-4057qib7 2658 38 n=74 n=74 NNP cord-005453-4057qib7 2658 39 receiving receive VBG cord-005453-4057qib7 2658 40 25 25 CD cord-005453-4057qib7 2658 41 mg mg NNP cord-005453-4057qib7 2658 42 / / SYM cord-005453-4057qib7 2658 43 kg kg NNP cord-005453-4057qib7 2658 44 / / SYM cord-005453-4057qib7 2658 45 day day NN cord-005453-4057qib7 2658 46 ) ) -RRB- cord-005453-4057qib7 2658 47 . . . cord-005453-4057qib7 2659 1 Safety safety NN cord-005453-4057qib7 2659 2 data datum NNS cord-005453-4057qib7 2659 3 for for IN cord-005453-4057qib7 2659 4 historical historical JJ cord-005453-4057qib7 2659 5 controls control NNS cord-005453-4057qib7 2659 6 ( ( -LRB- cord-005453-4057qib7 2659 7 HC HC NNP cord-005453-4057qib7 2659 8 ) ) -RRB- cord-005453-4057qib7 2659 9 from from IN cord-005453-4057qib7 2659 10 the the DT cord-005453-4057qib7 2659 11 phase phase NN cord-005453-4057qib7 2659 12 3 3 CD cord-005453-4057qib7 2659 13 study study NN cord-005453-4057qib7 2659 14 ( ( -LRB- cord-005453-4057qib7 2659 15 n=32 n=32 NNP cord-005453-4057qib7 2659 16 ) ) -RRB- cord-005453-4057qib7 2659 17 also also RB cord-005453-4057qib7 2659 18 are be VBP cord-005453-4057qib7 2659 19 provided provide VBN cord-005453-4057qib7 2659 20 . . . cord-005453-4057qib7 2660 1 Reported report VBN cord-005453-4057qib7 2660 2 separately separately RB cord-005453-4057qib7 2660 3 , , , cord-005453-4057qib7 2660 4 due due IN cord-005453-4057qib7 2660 5 to to IN cord-005453-4057qib7 2660 6 differences difference NNS cord-005453-4057qib7 2660 7 in in IN cord-005453-4057qib7 2660 8 patient patient JJ cord-005453-4057qib7 2660 9 population population NN cord-005453-4057qib7 2660 10 and and CC cord-005453-4057qib7 2660 11 data datum NNS cord-005453-4057qib7 2660 12 monitoring monitoring NN cord-005453-4057qib7 2660 13 protocol protocol NN cord-005453-4057qib7 2660 14 , , , cord-005453-4057qib7 2660 15 are be VBP cord-005453-4057qib7 2660 16 AEs ae NNS cord-005453-4057qib7 2660 17 from from IN cord-005453-4057qib7 2660 18 the the DT cord-005453-4057qib7 2660 19 expanded expand VBN cord-005453-4057qib7 2660 20 - - HYPH cord-005453-4057qib7 2660 21 access access NN cord-005453-4057qib7 2660 22 program program NN cord-005453-4057qib7 2661 1 ( ( -LRB- cord-005453-4057qib7 2661 2 T T NNP cord-005453-4057qib7 2661 3 - - HYPH cord-005453-4057qib7 2661 4 IND IND NNP cord-005453-4057qib7 2661 5 ) ) -RRB- cord-005453-4057qib7 2661 6 in in IN cord-005453-4057qib7 2661 7 patients patient NNS cord-005453-4057qib7 2661 8 with with IN cord-005453-4057qib7 2661 9 VOD/ VOD/ NNP cord-005453-4057qib7 2661 10 SOS SOS NNP cord-005453-4057qib7 2661 11 with with IN cord-005453-4057qib7 2661 12 and and CC cord-005453-4057qib7 2661 13 without without IN cord-005453-4057qib7 2661 14 MOD mod NN cord-005453-4057qib7 2661 15 ( ( -LRB- cord-005453-4057qib7 2661 16 n=1000 n=1000 CD cord-005453-4057qib7 2661 17 post post JJ cord-005453-4057qib7 2661 18 - - JJ cord-005453-4057qib7 2661 19 HSCT HSCT NNP cord-005453-4057qib7 2661 20 ) ) -RRB- cord-005453-4057qib7 2661 21 . . . cord-005453-4057qib7 2662 1 VOD/ VOD/ NNP cord-005453-4057qib7 2662 2 SOS SOS NNP cord-005453-4057qib7 2662 3 was be VBD cord-005453-4057qib7 2662 4 diagnosed diagnose VBN cord-005453-4057qib7 2662 5 by by IN cord-005453-4057qib7 2662 6 Baltimore Baltimore NNP cord-005453-4057qib7 2662 7 criteria criterion NNS cord-005453-4057qib7 2662 8 / / SYM cord-005453-4057qib7 2662 9 biopsy biopsy NN cord-005453-4057qib7 2662 10 for for IN cord-005453-4057qib7 2662 11 the the DT cord-005453-4057qib7 2662 12 phase phase NN cord-005453-4057qib7 2662 13 2/3 2/3 CD cord-005453-4057qib7 2662 14 studies study NNS cord-005453-4057qib7 2662 15 ; ; : cord-005453-4057qib7 2662 16 diagnosis diagnosis NN cord-005453-4057qib7 2662 17 by by IN cord-005453-4057qib7 2662 18 Baltimore Baltimore NNP cord-005453-4057qib7 2662 19 or or CC cord-005453-4057qib7 2662 20 modified modify VBN cord-005453-4057qib7 2662 21 Seattle Seattle NNP cord-005453-4057qib7 2662 22 criteria criterion NNS cord-005453-4057qib7 2662 23 was be VBD cord-005453-4057qib7 2662 24 permitted permit VBN cord-005453-4057qib7 2662 25 in in IN cord-005453-4057qib7 2662 26 the the DT cord-005453-4057qib7 2662 27 T T NNP cord-005453-4057qib7 2662 28 - - HYPH cord-005453-4057qib7 2662 29 IND IND NNP cord-005453-4057qib7 2662 30 . . . cord-005453-4057qib7 2663 1 Results result NNS cord-005453-4057qib7 2663 2 : : : cord-005453-4057qib7 2664 1 Median median JJ cord-005453-4057qib7 2664 2 patient patient JJ cord-005453-4057qib7 2664 3 age age NN cord-005453-4057qib7 2664 4 at at IN cord-005453-4057qib7 2664 5 HSCT HSCT NNP cord-005453-4057qib7 2664 6 for for IN cord-005453-4057qib7 2664 7 the the DT cord-005453-4057qib7 2664 8 phase phase NN cord-005453-4057qib7 2664 9 2/ 2/ CD cord-005453-4057qib7 2664 10 3 3 CD cord-005453-4057qib7 2664 11 studies study NNS cord-005453-4057qib7 2664 12 was be VBD cord-005453-4057qib7 2664 13 24.0 24.0 CD cord-005453-4057qib7 2664 14 years year NNS cord-005453-4057qib7 2664 15 , , , cord-005453-4057qib7 2664 16 18.0 18.0 CD cord-005453-4057qib7 2664 17 years year NNS cord-005453-4057qib7 2664 18 for for IN cord-005453-4057qib7 2664 19 the the DT cord-005453-4057qib7 2664 20 HC HC NNP cord-005453-4057qib7 2664 21 , , , cord-005453-4057qib7 2664 22 and and CC cord-005453-4057qib7 2664 23 14.0 14.0 CD cord-005453-4057qib7 2664 24 years year NNS cord-005453-4057qib7 2664 25 for for IN cord-005453-4057qib7 2664 26 the the DT cord-005453-4057qib7 2664 27 T T NNP cord-005453-4057qib7 2664 28 - - HYPH cord-005453-4057qib7 2664 29 IND IND NNP cord-005453-4057qib7 2664 30 . . . cord-005453-4057qib7 2665 1 In in IN cord-005453-4057qib7 2665 2 the the DT cord-005453-4057qib7 2665 3 phase phase NN cord-005453-4057qib7 2665 4 2/3 2/3 CD cord-005453-4057qib7 2665 5 studies study NNS cord-005453-4057qib7 2665 6 defibrotide defibrotide RB cord-005453-4057qib7 2665 7 - - HYPH cord-005453-4057qib7 2665 8 treated treat VBN cord-005453-4057qib7 2665 9 group group NN cord-005453-4057qib7 2665 10 ( ( -LRB- cord-005453-4057qib7 2665 11 n=176 n=176 NNP cord-005453-4057qib7 2665 12 ) ) -RRB- cord-005453-4057qib7 2665 13 , , , cord-005453-4057qib7 2665 14 169 169 CD cord-005453-4057qib7 2665 15 ( ( -LRB- cord-005453-4057qib7 2665 16 96.0 96.0 CD cord-005453-4057qib7 2665 17 % % NN cord-005453-4057qib7 2665 18 ) ) -RRB- cord-005453-4057qib7 2665 19 experienced experience VBD cord-005453-4057qib7 2665 20 AEs AEs NNPS cord-005453-4057qib7 2665 21 ; ; : cord-005453-4057qib7 2665 22 most most RBS cord-005453-4057qib7 2665 23 common common JJ cord-005453-4057qib7 2665 24 ( ( -LRB- cord-005453-4057qib7 2665 25 > > NFP cord-005453-4057qib7 2665 26 10 10 CD cord-005453-4057qib7 2665 27 % % NN cord-005453-4057qib7 2665 28 ) ) -RRB- cord-005453-4057qib7 2665 29 were be VBD cord-005453-4057qib7 2665 30 hypotension hypotension NN cord-005453-4057qib7 2665 31 ( ( -LRB- cord-005453-4057qib7 2665 32 36.9 36.9 CD cord-005453-4057qib7 2665 33 % % NN cord-005453-4057qib7 2665 34 ) ) -RRB- cord-005453-4057qib7 2665 35 , , , cord-005453-4057qib7 2665 36 diarrhea diarrhea NN cord-005453-4057qib7 2665 37 ( ( -LRB- cord-005453-4057qib7 2665 38 24.4 24.4 CD cord-005453-4057qib7 2665 39 % % NN cord-005453-4057qib7 2665 40 ) ) -RRB- cord-005453-4057qib7 2665 41 , , , cord-005453-4057qib7 2665 42 and and CC cord-005453-4057qib7 2665 43 multi multi JJ cord-005453-4057qib7 2665 44 - - JJ cord-005453-4057qib7 2665 45 organ organ JJ cord-005453-4057qib7 2665 46 failure failure NN cord-005453-4057qib7 2665 47 ( ( -LRB- cord-005453-4057qib7 2665 48 21.6 21.6 CD cord-005453-4057qib7 2665 49 % % NN cord-005453-4057qib7 2665 50 ) ) -RRB- cord-005453-4057qib7 2665 51 . . . cord-005453-4057qib7 2666 1 Treatment treatment NN cord-005453-4057qib7 2666 2 - - HYPH cord-005453-4057qib7 2666 3 related relate VBN cord-005453-4057qib7 2666 4 AEs ae NNS cord-005453-4057qib7 2666 5 were be VBD cord-005453-4057qib7 2666 6 at at IN cord-005453-4057qib7 2666 7 least least JJS cord-005453-4057qib7 2666 8 possibly possibly RB cord-005453-4057qib7 2666 9 related relate VBN cord-005453-4057qib7 2666 10 to to IN cord-005453-4057qib7 2666 11 defibrotide defibrotide NNP cord-005453-4057qib7 2666 12 ( ( -LRB- cord-005453-4057qib7 2666 13 Table table NN cord-005453-4057qib7 2666 14 ) ) -RRB- cord-005453-4057qib7 2666 15 . . . cord-005453-4057qib7 2667 1 Any any DT cord-005453-4057qib7 2667 2 hemorrhage hemorrhage NN cord-005453-4057qib7 2667 3 ( ( -LRB- cord-005453-4057qib7 2667 4 an an DT cord-005453-4057qib7 2667 5 AE ae NN cord-005453-4057qib7 2667 6 of of IN cord-005453-4057qib7 2667 7 special special JJ cord-005453-4057qib7 2667 8 interest interest NN cord-005453-4057qib7 2667 9 ) ) -RRB- cord-005453-4057qib7 2667 10 occurred occur VBD cord-005453-4057qib7 2667 11 in in IN cord-005453-4057qib7 2667 12 101 101 CD cord-005453-4057qib7 2667 13 patients patient NNS cord-005453-4057qib7 2667 14 ( ( -LRB- cord-005453-4057qib7 2667 15 57.4 57.4 CD cord-005453-4057qib7 2667 16 % % NN cord-005453-4057qib7 2667 17 ) ) -RRB- cord-005453-4057qib7 2667 18 ; ; : cord-005453-4057qib7 2667 19 most most RBS cord-005453-4057qib7 2667 20 commonly commonly RB cord-005453-4057qib7 2667 21 epistaxis epistaxis NN cord-005453-4057qib7 2667 22 ( ( -LRB- cord-005453-4057qib7 2667 23 13.6 13.6 CD cord-005453-4057qib7 2667 24 % % NN cord-005453-4057qib7 2667 25 ) ) -RRB- cord-005453-4057qib7 2667 26 , , , cord-005453-4057qib7 2667 27 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 2667 28 and and CC cord-005453-4057qib7 2667 29 pulmonary pulmonary JJ cord-005453-4057qib7 2667 30 alveolar alveolar NN cord-005453-4057qib7 2667 31 hemorrhage hemorrhage NN cord-005453-4057qib7 2667 32 and and CC cord-005453-4057qib7 2667 33 hematuria hematuria NN cord-005453-4057qib7 2667 34 ( ( -LRB- cord-005453-4057qib7 2667 35 8.5 8.5 CD cord-005453-4057qib7 2667 36 % % NN cord-005453-4057qib7 2667 37 each each DT cord-005453-4057qib7 2667 38 ) ) -RRB- cord-005453-4057qib7 2667 39 , , , cord-005453-4057qib7 2667 40 and and CC cord-005453-4057qib7 2667 41 conjunctival conjunctival NN cord-005453-4057qib7 2667 42 hemorrhage hemorrhage NN cord-005453-4057qib7 2667 43 ( ( -LRB- cord-005453-4057qib7 2667 44 6.3 6.3 CD cord-005453-4057qib7 2667 45 % % NN cord-005453-4057qib7 2667 46 ) ) -RRB- cord-005453-4057qib7 2667 47 . . . cord-005453-4057qib7 2668 1 All all DT cord-005453-4057qib7 2668 2 32 32 CD cord-005453-4057qib7 2668 3 HC HC NNP cord-005453-4057qib7 2668 4 experienced experience VBD cord-005453-4057qib7 2668 5 an an DT cord-005453-4057qib7 2668 6 AE ae NN cord-005453-4057qib7 2668 7 ; ; : cord-005453-4057qib7 2668 8 most most RBS cord-005453-4057qib7 2668 9 common common JJ cord-005453-4057qib7 2668 10 ( ( -LRB- cord-005453-4057qib7 2668 11 > > NFP cord-005453-4057qib7 2668 12 25 25 CD cord-005453-4057qib7 2668 13 % % NN cord-005453-4057qib7 2668 14 ) ) -RRB- cord-005453-4057qib7 2668 15 were be VBD cord-005453-4057qib7 2668 16 hypotension hypotension NN cord-005453-4057qib7 2668 17 ( ( -LRB- cord-005453-4057qib7 2668 18 50.0 50.0 CD cord-005453-4057qib7 2668 19 % % NN cord-005453-4057qib7 2668 20 ) ) -RRB- cord-005453-4057qib7 2668 21 , , , cord-005453-4057qib7 2668 22 tachycardia tachycardia NN cord-005453-4057qib7 2668 23 ( ( -LRB- cord-005453-4057qib7 2668 24 43.8 43.8 CD cord-005453-4057qib7 2668 25 % % NN cord-005453-4057qib7 2668 26 ) ) -RRB- cord-005453-4057qib7 2668 27 , , , cord-005453-4057qib7 2668 28 diarrhea diarrhea NN cord-005453-4057qib7 2668 29 ( ( -LRB- cord-005453-4057qib7 2668 30 37.5 37.5 CD cord-005453-4057qib7 2668 31 % % NN cord-005453-4057qib7 2668 32 ) ) -RRB- cord-005453-4057qib7 2668 33 , , , cord-005453-4057qib7 2668 34 nausea nausea NN cord-005453-4057qib7 2668 35 ( ( -LRB- cord-005453-4057qib7 2668 36 31.3 31.3 CD cord-005453-4057qib7 2668 37 % % NN cord-005453-4057qib7 2668 38 ) ) -RRB- cord-005453-4057qib7 2668 39 , , , cord-005453-4057qib7 2668 40 and and CC cord-005453-4057qib7 2668 41 pyrexia pyrexia NN cord-005453-4057qib7 2668 42 , , , cord-005453-4057qib7 2668 43 agitation agitation NN cord-005453-4057qib7 2668 44 , , , cord-005453-4057qib7 2668 45 and and CC cord-005453-4057qib7 2668 46 petechiae petechia NNS cord-005453-4057qib7 2668 47 ( ( -LRB- cord-005453-4057qib7 2668 48 28.1 28.1 CD cord-005453-4057qib7 2668 49 % % NN cord-005453-4057qib7 2668 50 each each DT cord-005453-4057qib7 2668 51 ) ) -RRB- cord-005453-4057qib7 2668 52 . . . cord-005453-4057qib7 2669 1 Any any DT cord-005453-4057qib7 2669 2 hemorrhage hemorrhage NN cord-005453-4057qib7 2669 3 occurred occur VBD cord-005453-4057qib7 2669 4 in in IN cord-005453-4057qib7 2669 5 24 24 CD cord-005453-4057qib7 2669 6 patients patient NNS cord-005453-4057qib7 2669 7 ( ( -LRB- cord-005453-4057qib7 2669 8 75.0 75.0 CD cord-005453-4057qib7 2669 9 % % NN cord-005453-4057qib7 2669 10 ) ) -RRB- cord-005453-4057qib7 2669 11 : : : cord-005453-4057qib7 2669 12 most most RBS cord-005453-4057qib7 2669 13 common common JJ cord-005453-4057qib7 2669 14 ( ( -LRB- cord-005453-4057qib7 2669 15 > > NFP cord-005453-4057qib7 2669 16 10 10 CD cord-005453-4057qib7 2669 17 % % NN cord-005453-4057qib7 2669 18 ) ) -RRB- cord-005453-4057qib7 2669 19 were be VBD cord-005453-4057qib7 2669 20 petechiae petechia NNS cord-005453-4057qib7 2669 21 ( ( -LRB- cord-005453-4057qib7 2669 22 28.1 28.1 CD cord-005453-4057qib7 2669 23 % % NN cord-005453-4057qib7 2669 24 ) ) -RRB- cord-005453-4057qib7 2669 25 ; ; : cord-005453-4057qib7 2669 26 hematuria hematuria NN cord-005453-4057qib7 2669 27 , , , cord-005453-4057qib7 2669 28 epistaxis epistaxis NN cord-005453-4057qib7 2669 29 , , , cord-005453-4057qib7 2669 30 and and CC cord-005453-4057qib7 2669 31 pulmonary pulmonary JJ cord-005453-4057qib7 2669 32 alveolar alveolar NN cord-005453-4057qib7 2669 33 hemorrhage hemorrhage NN cord-005453-4057qib7 2669 34 ( ( -LRB- cord-005453-4057qib7 2669 35 15.6 15.6 CD cord-005453-4057qib7 2669 36 % % NN cord-005453-4057qib7 2669 37 each each DT cord-005453-4057qib7 2669 38 ) ) -RRB- cord-005453-4057qib7 2669 39 ; ; : cord-005453-4057qib7 2669 40 and and CC cord-005453-4057qib7 2669 41 lip lip NN cord-005453-4057qib7 2669 42 hemorrhage hemorrhage NN cord-005453-4057qib7 2669 43 ( ( -LRB- cord-005453-4057qib7 2669 44 12.5 12.5 CD cord-005453-4057qib7 2669 45 % % NN cord-005453-4057qib7 2669 46 ) ) -RRB- cord-005453-4057qib7 2669 47 . . . cord-005453-4057qib7 2670 1 In in IN cord-005453-4057qib7 2670 2 the the DT cord-005453-4057qib7 2670 3 T T NNP cord-005453-4057qib7 2670 4 - - HYPH cord-005453-4057qib7 2670 5 IND IND NNP cord-005453-4057qib7 2670 6 ( ( -LRB- cord-005453-4057qib7 2670 7 n=1000 n=1000 CD cord-005453-4057qib7 2670 8 ) ) -RRB- cord-005453-4057qib7 2670 9 , , , cord-005453-4057qib7 2670 10 385/512 385/512 CD cord-005453-4057qib7 2670 11 patients patient NNS cord-005453-4057qib7 2670 12 with with IN cord-005453-4057qib7 2670 13 MOD mod NN cord-005453-4057qib7 2670 14 ( ( -LRB- cord-005453-4057qib7 2670 15 75.2 75.2 CD cord-005453-4057qib7 2670 16 % % NN cord-005453-4057qib7 2670 17 ) ) -RRB- cord-005453-4057qib7 2670 18 and and CC cord-005453-4057qib7 2670 19 324/488 324/488 CD cord-005453-4057qib7 2670 20 patients patient NNS cord-005453-4057qib7 2670 21 without without IN cord-005453-4057qib7 2670 22 MOD mod NN cord-005453-4057qib7 2670 23 ( ( -LRB- cord-005453-4057qib7 2670 24 66.4 66.4 CD cord-005453-4057qib7 2670 25 % % NN cord-005453-4057qib7 2670 26 ) ) -RRB- cord-005453-4057qib7 2670 27 had have VBD cord-005453-4057qib7 2670 28 an an DT cord-005453-4057qib7 2670 29 AE ae NN cord-005453-4057qib7 2670 30 ; ; : cord-005453-4057qib7 2670 31 other other JJ cord-005453-4057qib7 2670 32 than than IN cord-005453-4057qib7 2670 33 VOD VOD NNP cord-005453-4057qib7 2670 34 / / SYM cord-005453-4057qib7 2670 35 SOS SOS NNP cord-005453-4057qib7 2670 36 and and CC cord-005453-4057qib7 2670 37 MOD MOD NNP cord-005453-4057qib7 2670 38 , , , cord-005453-4057qib7 2670 39 most most RBS cord-005453-4057qib7 2670 40 commonly commonly RB cord-005453-4057qib7 2670 41 ( ( -LRB- cord-005453-4057qib7 2670 42 > > NFP cord-005453-4057qib7 2670 43 10 10 CD cord-005453-4057qib7 2670 44 % % NN cord-005453-4057qib7 2670 45 in in IN cord-005453-4057qib7 2670 46 either either DT cord-005453-4057qib7 2670 47 subgroup subgroup NN cord-005453-4057qib7 2670 48 ) ) -RRB- cord-005453-4057qib7 2671 1 hypotension hypotension NN cord-005453-4057qib7 2671 2 ( ( -LRB- cord-005453-4057qib7 2671 3 15.2 15.2 CD cord-005453-4057qib7 2671 4 % % NN cord-005453-4057qib7 2671 5 and and CC cord-005453-4057qib7 2671 6 8.4 8.4 CD cord-005453-4057qib7 2671 7 % % NN cord-005453-4057qib7 2671 8 , , , cord-005453-4057qib7 2671 9 respectively respectively RB cord-005453-4057qib7 2671 10 ) ) -RRB- cord-005453-4057qib7 2671 11 . . . cord-005453-4057qib7 2672 1 TRAEs trae NNS cord-005453-4057qib7 2672 2 occurred occur VBD cord-005453-4057qib7 2672 3 in in IN cord-005453-4057qib7 2672 4 210 210 CD cord-005453-4057qib7 2672 5 patients patient NNS cord-005453-4057qib7 2672 6 ( ( -LRB- cord-005453-4057qib7 2672 7 21.0 21.0 CD cord-005453-4057qib7 2672 8 % % NN cord-005453-4057qib7 2672 9 ) ) -RRB- cord-005453-4057qib7 2672 10 ( ( -LRB- cord-005453-4057qib7 2672 11 Table table NN cord-005453-4057qib7 2672 12 ) ) -RRB- cord-005453-4057qib7 2672 13 . . . cord-005453-4057qib7 2673 1 Any any DT cord-005453-4057qib7 2673 2 treatment treatment NN cord-005453-4057qib7 2673 3 - - HYPH cord-005453-4057qib7 2673 4 emergent emergent JJ cord-005453-4057qib7 2673 5 hemorrhage hemorrhage NN cord-005453-4057qib7 2673 6 occurred occur VBD cord-005453-4057qib7 2673 7 in in IN cord-005453-4057qib7 2673 8 166 166 CD cord-005453-4057qib7 2673 9 patients patient NNS cord-005453-4057qib7 2673 10 with with IN cord-005453-4057qib7 2673 11 MOD mod NN cord-005453-4057qib7 2673 12 ( ( -LRB- cord-005453-4057qib7 2673 13 32.4 32.4 CD cord-005453-4057qib7 2673 14 % % NN cord-005453-4057qib7 2673 15 ) ) -RRB- cord-005453-4057qib7 2673 16 and and CC cord-005453-4057qib7 2673 17 124 124 CD cord-005453-4057qib7 2673 18 patients patient NNS cord-005453-4057qib7 2673 19 without without IN cord-005453-4057qib7 2673 20 MOD mod NN cord-005453-4057qib7 2673 21 ( ( -LRB- cord-005453-4057qib7 2673 22 25.4 25.4 CD cord-005453-4057qib7 2673 23 % % NN cord-005453-4057qib7 2673 24 ) ) -RRB- cord-005453-4057qib7 2673 25 ; ; : cord-005453-4057qib7 2673 26 most most RBS cord-005453-4057qib7 2673 27 commonly commonly RB cord-005453-4057qib7 2673 28 ( ( -LRB- cord-005453-4057qib7 2673 29 > > NFP cord-005453-4057qib7 2673 30 5 5 CD cord-005453-4057qib7 2673 31 % % NN cord-005453-4057qib7 2673 32 in in IN cord-005453-4057qib7 2673 33 either either DT cord-005453-4057qib7 2673 34 subgroup subgroup NN cord-005453-4057qib7 2673 35 ) ) -RRB- cord-005453-4057qib7 2673 36 pulmonary pulmonary JJ cord-005453-4057qib7 2673 37 hemorrhage hemorrhage NN cord-005453-4057qib7 2673 38 ( ( -LRB- cord-005453-4057qib7 2673 39 8.2 8.2 CD cord-005453-4057qib7 2673 40 % % NN cord-005453-4057qib7 2673 41 and and CC cord-005453-4057qib7 2673 42 4.7 4.7 CD cord-005453-4057qib7 2673 43 % % NN cord-005453-4057qib7 2673 44 , , , cord-005453-4057qib7 2673 45 respectively respectively RB cord-005453-4057qib7 2673 46 ) ) -RRB- cord-005453-4057qib7 2673 47 and and CC cord-005453-4057qib7 2673 48 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 2673 49 hemorrhage hemorrhage NN cord-005453-4057qib7 2673 50 ( ( -LRB- cord-005453-4057qib7 2673 51 5.5 5.5 CD cord-005453-4057qib7 2673 52 % % NN cord-005453-4057qib7 2673 53 and and CC cord-005453-4057qib7 2673 54 4.3 4.3 CD cord-005453-4057qib7 2673 55 % % NN cord-005453-4057qib7 2673 56 , , , cord-005453-4057qib7 2673 57 respectively respectively RB cord-005453-4057qib7 2673 58 ) ) -RRB- cord-005453-4057qib7 2673 59 . . . cord-005453-4057qib7 2674 1 Conclusions conclusion NNS cord-005453-4057qib7 2674 2 : : : cord-005453-4057qib7 2675 1 The the DT cord-005453-4057qib7 2675 2 incidence incidence NN cord-005453-4057qib7 2675 3 and and CC cord-005453-4057qib7 2675 4 type type NN cord-005453-4057qib7 2675 5 of of IN cord-005453-4057qib7 2675 6 AEs ae NNS cord-005453-4057qib7 2675 7 were be VBD cord-005453-4057qib7 2675 8 as as IN cord-005453-4057qib7 2675 9 expected expect VBN cord-005453-4057qib7 2675 10 in in IN cord-005453-4057qib7 2675 11 these these DT cord-005453-4057qib7 2675 12 critically critically RB cord-005453-4057qib7 2675 13 ill ill JJ cord-005453-4057qib7 2675 14 patients patient NNS cord-005453-4057qib7 2675 15 . . . cord-005453-4057qib7 2676 1 Of of IN cord-005453-4057qib7 2676 2 the the DT cord-005453-4057qib7 2676 3 pooled pool VBN cord-005453-4057qib7 2676 4 patients patient NNS cord-005453-4057qib7 2676 5 , , , cord-005453-4057qib7 2676 6 96 96 CD cord-005453-4057qib7 2676 7 % % NN cord-005453-4057qib7 2676 8 had have VBD cord-005453-4057qib7 2676 9 AEs ae NNS cord-005453-4057qib7 2676 10 ; ; : cord-005453-4057qib7 2676 11 57.4 57.4 CD cord-005453-4057qib7 2676 12 % % NN cord-005453-4057qib7 2676 13 had have VBD cord-005453-4057qib7 2676 14 a a DT cord-005453-4057qib7 2676 15 hemorrhage hemorrhage NN cord-005453-4057qib7 2676 16 . . . cord-005453-4057qib7 2677 1 All all DT cord-005453-4057qib7 2677 2 HCs hc NNS cord-005453-4057qib7 2677 3 had have VBD cord-005453-4057qib7 2677 4 an an DT cord-005453-4057qib7 2677 5 AE AE NNP cord-005453-4057qib7 2677 6 , , , cord-005453-4057qib7 2677 7 with with IN cord-005453-4057qib7 2677 8 75.0 75.0 CD cord-005453-4057qib7 2677 9 % % NN cord-005453-4057qib7 2677 10 having have VBG cord-005453-4057qib7 2677 11 a a DT cord-005453-4057qib7 2677 12 hemorrhage hemorrhage NN cord-005453-4057qib7 2677 13 . . . cord-005453-4057qib7 2678 1 In in IN cord-005453-4057qib7 2678 2 the the DT cord-005453-4057qib7 2678 3 T T NNP cord-005453-4057qib7 2678 4 - - HYPH cord-005453-4057qib7 2678 5 IND IND NNP cord-005453-4057qib7 2678 6 , , , cord-005453-4057qib7 2678 7 patients patient NNS cord-005453-4057qib7 2678 8 with with IN cord-005453-4057qib7 2678 9 MOD MOD NNP cord-005453-4057qib7 2678 10 had have VBD cord-005453-4057qib7 2678 11 higher high JJR cord-005453-4057qib7 2678 12 rates rate NNS cord-005453-4057qib7 2678 13 of of IN cord-005453-4057qib7 2678 14 AEs ae NNS cord-005453-4057qib7 2678 15 . . . cord-005453-4057qib7 2679 1 Support support NN cord-005453-4057qib7 2679 2 : : : cord-005453-4057qib7 2679 3 Jazz Jazz NNP cord-005453-4057qib7 2679 4 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 2679 5 Event Event NNP cord-005453-4057qib7 2679 6 , , , cord-005453-4057qib7 2679 7 n(% n(% -RRB- cord-005453-4057qib7 2679 8 ) ) -RRB- cord-005453-4057qib7 2680 1 Phase phase NN cord-005453-4057qib7 2680 2 2/3 2/3 CD cord-005453-4057qib7 2680 3 studies study NNS cord-005453-4057qib7 2680 4 ( ( -LRB- cord-005453-4057qib7 2680 5 n=176 n=176 CD cord-005453-4057qib7 2680 6 ) ) -RRB- cord-005453-4057qib7 2681 1 Disclosure disclosure NN cord-005453-4057qib7 2681 2 : : : cord-005453-4057qib7 2682 1 Paul Paul NNP cord-005453-4057qib7 2682 2 G. G. NNP cord-005453-4057qib7 2682 3 Richardson Richardson NNP cord-005453-4057qib7 2682 4 has have VBZ cord-005453-4057qib7 2682 5 served serve VBN cord-005453-4057qib7 2682 6 on on IN cord-005453-4057qib7 2682 7 advisory advisory JJ cord-005453-4057qib7 2682 8 committees committee NNS cord-005453-4057qib7 2682 9 and and CC cord-005453-4057qib7 2682 10 as as IN cord-005453-4057qib7 2682 11 a a DT cord-005453-4057qib7 2682 12 consultant consultant NN cord-005453-4057qib7 2682 13 , , , cord-005453-4057qib7 2682 14 and and CC cord-005453-4057qib7 2682 15 has have VBZ cord-005453-4057qib7 2682 16 received receive VBN cord-005453-4057qib7 2682 17 research research NN cord-005453-4057qib7 2682 18 funding funding NN cord-005453-4057qib7 2682 19 from from IN cord-005453-4057qib7 2682 20 Jazz Jazz NNP cord-005453-4057qib7 2682 21 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2682 22 . . . cord-005453-4057qib7 2683 1 Angela Angela NNP cord-005453-4057qib7 2683 2 R. R. NNP cord-005453-4057qib7 2683 3 Smith Smith NNP cord-005453-4057qib7 2683 4 and and CC cord-005453-4057qib7 2683 5 Leslie Leslie NNP cord-005453-4057qib7 2683 6 Lehmann Lehmann NNP cord-005453-4057qib7 2683 7 have have VBP cord-005453-4057qib7 2683 8 nothing nothing NN cord-005453-4057qib7 2683 9 to to TO cord-005453-4057qib7 2683 10 disclose disclose VB cord-005453-4057qib7 2683 11 . . . cord-005453-4057qib7 2684 1 Nancy Nancy NNP cord-005453-4057qib7 2684 2 A. A. NNP cord-005453-4057qib7 2684 3 Kernan Kernan NNP cord-005453-4057qib7 2684 4 received receive VBD cord-005453-4057qib7 2684 5 grants grant NNS cord-005453-4057qib7 2684 6 from from IN cord-005453-4057qib7 2684 7 Gentium Gentium NNP cord-005453-4057qib7 2684 8 during during IN cord-005453-4057qib7 2684 9 the the DT cord-005453-4057qib7 2684 10 conduct conduct NN cord-005453-4057qib7 2684 11 of of IN cord-005453-4057qib7 2684 12 the the DT cord-005453-4057qib7 2684 13 study study NN cord-005453-4057qib7 2684 14 , , , cord-005453-4057qib7 2684 15 and and CC cord-005453-4057qib7 2684 16 her -PRON- PRP$ cord-005453-4057qib7 2684 17 research research NN cord-005453-4057qib7 2684 18 was be VBD cord-005453-4057qib7 2684 19 supported support VBN cord-005453-4057qib7 2684 20 by by IN cord-005453-4057qib7 2684 21 The the DT cord-005453-4057qib7 2684 22 National National NNP cord-005453-4057qib7 2684 23 Cancer Cancer NNP cord-005453-4057qib7 2684 24 Institute Institute NNP cord-005453-4057qib7 2684 25 of of IN cord-005453-4057qib7 2684 26 the the DT cord-005453-4057qib7 2684 27 National National NNP cord-005453-4057qib7 2684 28 Institutes Institutes NNPS cord-005453-4057qib7 2684 29 of of IN cord-005453-4057qib7 2684 30 Health Health NNP cord-005453-4057qib7 2684 31 under under IN cord-005453-4057qib7 2684 32 award award NN cord-005453-4057qib7 2684 33 number number NN cord-005453-4057qib7 2684 34 P30 P30 NNP cord-005453-4057qib7 2684 35 CA008748 CA008748 NNP cord-005453-4057qib7 2684 36 ; ; : cord-005453-4057qib7 2684 37 the the DT cord-005453-4057qib7 2684 38 content content NN cord-005453-4057qib7 2684 39 is be VBZ cord-005453-4057qib7 2684 40 solely solely RB cord-005453-4057qib7 2684 41 the the DT cord-005453-4057qib7 2684 42 responsibility responsibility NN cord-005453-4057qib7 2684 43 of of IN cord-005453-4057qib7 2684 44 the the DT cord-005453-4057qib7 2684 45 author author NN cord-005453-4057qib7 2684 46 and and CC cord-005453-4057qib7 2684 47 does do VBZ cord-005453-4057qib7 2684 48 not not RB cord-005453-4057qib7 2684 49 necessarily necessarily RB cord-005453-4057qib7 2684 50 represent represent VB cord-005453-4057qib7 2684 51 the the DT cord-005453-4057qib7 2684 52 official official JJ cord-005453-4057qib7 2684 53 views view NNS cord-005453-4057qib7 2684 54 of of IN cord-005453-4057qib7 2684 55 the the DT cord-005453-4057qib7 2684 56 National National NNP cord-005453-4057qib7 2684 57 Institutes Institutes NNPS cord-005453-4057qib7 2684 58 of of IN cord-005453-4057qib7 2684 59 Health Health NNP cord-005453-4057qib7 2684 60 . . . cord-005453-4057qib7 2685 1 She -PRON- PRP cord-005453-4057qib7 2685 2 has have VBZ cord-005453-4057qib7 2685 3 a a DT cord-005453-4057qib7 2685 4 research research NN cord-005453-4057qib7 2685 5 grant grant NN cord-005453-4057qib7 2685 6 from from IN cord-005453-4057qib7 2685 7 Jazz Jazz NNP cord-005453-4057qib7 2685 8 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2685 9 . . . cord-005453-4057qib7 2686 1 Robert Robert NNP cord-005453-4057qib7 2686 2 Ryan Ryan NNP cord-005453-4057qib7 2686 3 and and CC cord-005453-4057qib7 2686 4 William William NNP cord-005453-4057qib7 2686 5 Tappe Tappe NNP cord-005453-4057qib7 2686 6 are be VBP cord-005453-4057qib7 2686 7 employees employee NNS cord-005453-4057qib7 2686 8 of of IN cord-005453-4057qib7 2686 9 Jazz Jazz NNP cord-005453-4057qib7 2686 10 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2686 11 and and CC cord-005453-4057qib7 2686 12 hold hold VB cord-005453-4057qib7 2686 13 stock stock NN cord-005453-4057qib7 2686 14 and/or and/or CC cord-005453-4057qib7 2686 15 stock stock NN cord-005453-4057qib7 2686 16 options option NNS cord-005453-4057qib7 2686 17 in in IN cord-005453-4057qib7 2686 18 Jazz Jazz NNP cord-005453-4057qib7 2686 19 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 2686 20 plc plc NNP cord-005453-4057qib7 2686 21 . . . cord-005453-4057qib7 2687 1 Stephan Stephan NNP cord-005453-4057qib7 2687 2 A. A. NNP cord-005453-4057qib7 2687 3 Grupp Grupp NNP cord-005453-4057qib7 2687 4 has have VBZ cord-005453-4057qib7 2687 5 served serve VBN cord-005453-4057qib7 2687 6 on on IN cord-005453-4057qib7 2687 7 a a DT cord-005453-4057qib7 2687 8 steering steering NN cord-005453-4057qib7 2687 9 committee committee NN cord-005453-4057qib7 2687 10 and and CC cord-005453-4057qib7 2687 11 as as IN cord-005453-4057qib7 2687 12 a a DT cord-005453-4057qib7 2687 13 consultant consultant NN cord-005453-4057qib7 2687 14 to to IN cord-005453-4057qib7 2687 15 Jazz Jazz NNP cord-005453-4057qib7 2687 16 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2687 17 . . . cord-005453-4057qib7 2688 1 Defibrotide Defibrotide NNP cord-005453-4057qib7 2688 2 for for IN cord-005453-4057qib7 2688 3 treatment treatment NN cord-005453-4057qib7 2688 4 of of IN cord-005453-4057qib7 2688 5 adults adult NNS cord-005453-4057qib7 2688 6 with with IN cord-005453-4057qib7 2688 7 hepatic hepatic JJ cord-005453-4057qib7 2688 8 VOD/ VOD/ NNP cord-005453-4057qib7 2688 9 SOS SOS NNP cord-005453-4057qib7 2688 10 with with IN cord-005453-4057qib7 2688 11 or or CC cord-005453-4057qib7 2688 12 without without IN cord-005453-4057qib7 2688 13 multiorgan multiorgan NN cord-005453-4057qib7 2688 14 failure failure NN cord-005453-4057qib7 2688 15 after after IN cord-005453-4057qib7 2688 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 2688 17 cell cell NN cord-005453-4057qib7 2688 18 transplantation transplantation NN cord-005453-4057qib7 2688 19 : : : cord-005453-4057qib7 2688 20 Results result NNS cord-005453-4057qib7 2688 21 of of IN cord-005453-4057qib7 2688 22 a a DT cord-005453-4057qib7 2688 23 systematic systematic JJ cord-005453-4057qib7 2688 24 review review NN cord-005453-4057qib7 2688 25 / / SYM cord-005453-4057qib7 2688 26 meta meta NN cord-005453-4057qib7 2688 27 - - HYPH cord-005453-4057qib7 2688 28 analysis analysis NN cord-005453-4057qib7 2688 29 Background background NN cord-005453-4057qib7 2688 30 : : : cord-005453-4057qib7 2688 31 Although although IN cord-005453-4057qib7 2688 32 hematopoietic hematopoietic JJ cord-005453-4057qib7 2688 33 cell cell NN cord-005453-4057qib7 2688 34 transplantation transplantation NN cord-005453-4057qib7 2688 35 ( ( -LRB- cord-005453-4057qib7 2688 36 HCT HCT NNP cord-005453-4057qib7 2688 37 ) ) -RRB- cord-005453-4057qib7 2688 38 , , , cord-005453-4057qib7 2688 39 autologous autologous JJ cord-005453-4057qib7 2688 40 or or CC cord-005453-4057qib7 2688 41 allogeneic allogeneic NN cord-005453-4057qib7 2688 42 , , , cord-005453-4057qib7 2688 43 is be VBZ cord-005453-4057qib7 2688 44 potentially potentially RB cord-005453-4057qib7 2688 45 curable curable JJ cord-005453-4057qib7 2688 46 in in IN cord-005453-4057qib7 2688 47 various various JJ cord-005453-4057qib7 2688 48 hematologic hematologic JJ cord-005453-4057qib7 2688 49 malignancies malignancy NNS cord-005453-4057qib7 2688 50 , , , cord-005453-4057qib7 2688 51 the the DT cord-005453-4057qib7 2688 52 procedure procedure NN cord-005453-4057qib7 2688 53 is be VBZ cord-005453-4057qib7 2688 54 associated associate VBN cord-005453-4057qib7 2688 55 with with IN cord-005453-4057qib7 2688 56 serious serious JJ cord-005453-4057qib7 2688 57 and and CC cord-005453-4057qib7 2688 58 potentially potentially RB cord-005453-4057qib7 2688 59 life life NN cord-005453-4057qib7 2688 60 - - HYPH cord-005453-4057qib7 2688 61 threatening threaten VBG cord-005453-4057qib7 2688 62 complications complication NNS cord-005453-4057qib7 2688 63 , , , cord-005453-4057qib7 2688 64 among among IN cord-005453-4057qib7 2688 65 them -PRON- PRP cord-005453-4057qib7 2688 66 veno veno NNP cord-005453-4057qib7 2688 67 - - HYPH cord-005453-4057qib7 2688 68 occlusive occlusive JJ cord-005453-4057qib7 2688 69 disease disease NN cord-005453-4057qib7 2688 70 / / , cord-005453-4057qib7 2688 71 sinusoidal sinusoidal JJ cord-005453-4057qib7 2688 72 obstructive obstructive JJ cord-005453-4057qib7 2688 73 syndrome syndrome NN cord-005453-4057qib7 2688 74 ( ( -LRB- cord-005453-4057qib7 2688 75 VOD VOD NNP cord-005453-4057qib7 2688 76 / / SYM cord-005453-4057qib7 2688 77 SOS SOS NNP cord-005453-4057qib7 2688 78 ) ) -RRB- cord-005453-4057qib7 2688 79 of of IN cord-005453-4057qib7 2688 80 the the DT cord-005453-4057qib7 2688 81 liver liver NN cord-005453-4057qib7 2688 82 . . . cord-005453-4057qib7 2689 1 Several several JJ cord-005453-4057qib7 2689 2 studies study NNS cord-005453-4057qib7 2689 3 , , , cord-005453-4057qib7 2689 4 prospective prospective JJ cord-005453-4057qib7 2689 5 or or CC cord-005453-4057qib7 2689 6 retrospective retrospective JJ cord-005453-4057qib7 2689 7 , , , cord-005453-4057qib7 2689 8 have have VBP cord-005453-4057qib7 2689 9 reported report VBN cord-005453-4057qib7 2689 10 outcomes outcome NNS cord-005453-4057qib7 2689 11 of of IN cord-005453-4057qib7 2689 12 defibrotide defibrotide NN cord-005453-4057qib7 2689 13 , , , cord-005453-4057qib7 2689 14 when when WRB cord-005453-4057qib7 2689 15 used use VBN cord-005453-4057qib7 2689 16 as as IN cord-005453-4057qib7 2689 17 prophylaxis prophylaxis NN cord-005453-4057qib7 2689 18 or or CC cord-005453-4057qib7 2689 19 treatment treatment NN cord-005453-4057qib7 2689 20 , , , cord-005453-4057qib7 2689 21 in in IN cord-005453-4057qib7 2689 22 a a DT cord-005453-4057qib7 2689 23 mixed mixed JJ cord-005453-4057qib7 2689 24 population population NN cord-005453-4057qib7 2689 25 of of IN cord-005453-4057qib7 2689 26 adult adult NN cord-005453-4057qib7 2689 27 and and CC cord-005453-4057qib7 2689 28 pediatric pediatric JJ cord-005453-4057qib7 2689 29 patients patient NNS cord-005453-4057qib7 2689 30 . . . cord-005453-4057qib7 2690 1 In in IN cord-005453-4057qib7 2690 2 this this DT cord-005453-4057qib7 2690 3 systematic systematic JJ cord-005453-4057qib7 2690 4 review review NN cord-005453-4057qib7 2690 5 / / SYM cord-005453-4057qib7 2690 6 meta meta NN cord-005453-4057qib7 2690 7 - - HYPH cord-005453-4057qib7 2690 8 analysis analysis NN cord-005453-4057qib7 2690 9 , , , cord-005453-4057qib7 2690 10 we -PRON- PRP cord-005453-4057qib7 2690 11 analyze analyze VBP cord-005453-4057qib7 2690 12 outcomes outcome NNS cord-005453-4057qib7 2690 13 of of IN cord-005453-4057qib7 2690 14 defibrotide defibrotide NN cord-005453-4057qib7 2690 15 when when WRB cord-005453-4057qib7 2690 16 specifically specifically RB cord-005453-4057qib7 2690 17 used use VBN cord-005453-4057qib7 2690 18 for for IN cord-005453-4057qib7 2690 19 treatment treatment NN cord-005453-4057qib7 2690 20 of of IN cord-005453-4057qib7 2690 21 adult adult NN cord-005453-4057qib7 2690 22 patients patient NNS cord-005453-4057qib7 2690 23 with with IN cord-005453-4057qib7 2690 24 hepatic hepatic JJ cord-005453-4057qib7 2690 25 VOD VOD NNP cord-005453-4057qib7 2690 26 / / SYM cord-005453-4057qib7 2690 27 SOS SOS NNP cord-005453-4057qib7 2690 28 with with IN cord-005453-4057qib7 2690 29 or or CC cord-005453-4057qib7 2690 30 without without IN cord-005453-4057qib7 2690 31 multiorgan multiorgan NN cord-005453-4057qib7 2690 32 failure failure NN cord-005453-4057qib7 2690 33 . . . cord-005453-4057qib7 2691 1 Methods method NNS cord-005453-4057qib7 2691 2 : : : cord-005453-4057qib7 2692 1 A a DT cord-005453-4057qib7 2692 2 comprehensive comprehensive JJ cord-005453-4057qib7 2692 3 search search NN cord-005453-4057qib7 2692 4 of of IN cord-005453-4057qib7 2692 5 3 3 CD cord-005453-4057qib7 2692 6 large large JJ cord-005453-4057qib7 2692 7 databases database NNS cord-005453-4057qib7 2692 8 ( ( -LRB- cord-005453-4057qib7 2692 9 Medline Medline NNP cord-005453-4057qib7 2692 10 / / SYM cord-005453-4057qib7 2692 11 Pubmed Pubmed NNP cord-005453-4057qib7 2692 12 , , , cord-005453-4057qib7 2692 13 Cochrane Cochrane NNP cord-005453-4057qib7 2692 14 and and CC cord-005453-4057qib7 2692 15 EMBASE EMBASE NNP cord-005453-4057qib7 2692 16 ) ) -RRB- cord-005453-4057qib7 2692 17 on on IN cord-005453-4057qib7 2692 18 November November NNP cord-005453-4057qib7 2692 19 2 2 CD cord-005453-4057qib7 2692 20 , , , cord-005453-4057qib7 2692 21 2018 2018 CD cord-005453-4057qib7 2692 22 identified identify VBD cord-005453-4057qib7 2692 23 642 642 CD cord-005453-4057qib7 2692 24 publications publication NNS cord-005453-4057qib7 2692 25 . . . cord-005453-4057qib7 2693 1 Analysis analysis NN cord-005453-4057qib7 2693 2 was be VBD cord-005453-4057qib7 2693 3 restricted restrict VBN cord-005453-4057qib7 2693 4 only only RB cord-005453-4057qib7 2693 5 to to IN cord-005453-4057qib7 2693 6 adult adult NN cord-005453-4057qib7 2693 7 patients patient NNS cord-005453-4057qib7 2693 8 ( ( -LRB- cord-005453-4057qib7 2693 9 defined define VBN cord-005453-4057qib7 2693 10 as as IN cord-005453-4057qib7 2693 11 median median JJ cord-005453-4057qib7 2693 12 age age NN cord-005453-4057qib7 2693 13 older old JJR cord-005453-4057qib7 2693 14 than than IN cord-005453-4057qib7 2693 15 16 16 CD cord-005453-4057qib7 2693 16 years year NNS cord-005453-4057qib7 2693 17 ) ) -RRB- cord-005453-4057qib7 2693 18 who who WP cord-005453-4057qib7 2693 19 received receive VBD cord-005453-4057qib7 2693 20 defibrotide defibrotide NN cord-005453-4057qib7 2693 21 for for IN cord-005453-4057qib7 2693 22 treatment treatment NN cord-005453-4057qib7 2693 23 of of IN cord-005453-4057qib7 2693 24 VOD VOD NNP cord-005453-4057qib7 2693 25 / / SYM cord-005453-4057qib7 2693 26 SOS SOS NNP cord-005453-4057qib7 2693 27 and and CC cord-005453-4057qib7 2693 28 were be VBD cord-005453-4057qib7 2693 29 reported report VBN cord-005453-4057qib7 2693 30 in in IN cord-005453-4057qib7 2693 31 prospective prospective JJ cord-005453-4057qib7 2693 32 or or CC cord-005453-4057qib7 2693 33 retrospective retrospective JJ cord-005453-4057qib7 2693 34 ( ( -LRB- cord-005453-4057qib7 2693 35 which which WDT cord-005453-4057qib7 2693 36 included include VBD cord-005453-4057qib7 2693 37 ≥ ≥ CD cord-005453-4057qib7 2693 38 5 5 CD cord-005453-4057qib7 2693 39 patients patient NNS cord-005453-4057qib7 2693 40 ) ) -RRB- cord-005453-4057qib7 2693 41 studies study NNS cord-005453-4057qib7 2693 42 published publish VBN cord-005453-4057qib7 2693 43 in in IN cord-005453-4057qib7 2693 44 full full JJ cord-005453-4057qib7 2693 45 manuscript manuscript NN cord-005453-4057qib7 2693 46 form form NN cord-005453-4057qib7 2693 47 . . . cord-005453-4057qib7 2694 1 There there EX cord-005453-4057qib7 2694 2 were be VBD cord-005453-4057qib7 2694 3 no no DT cord-005453-4057qib7 2694 4 limitations limitation NNS cord-005453-4057qib7 2694 5 based base VBN cord-005453-4057qib7 2694 6 on on IN cord-005453-4057qib7 2694 7 language language NN cord-005453-4057qib7 2694 8 . . . cord-005453-4057qib7 2695 1 Data datum NNS cord-005453-4057qib7 2695 2 were be VBD cord-005453-4057qib7 2695 3 extracted extract VBN cord-005453-4057qib7 2695 4 in in IN cord-005453-4057qib7 2695 5 relation relation NN cord-005453-4057qib7 2695 6 to to IN cord-005453-4057qib7 2695 7 benefits benefit NNS cord-005453-4057qib7 2695 8 [ [ -LRB- cord-005453-4057qib7 2695 9 complete complete JJ cord-005453-4057qib7 2695 10 remission remission NN cord-005453-4057qib7 2695 11 ( ( -LRB- cord-005453-4057qib7 2695 12 CR cr NN cord-005453-4057qib7 2695 13 ) ) -RRB- cord-005453-4057qib7 2695 14 rate rate NN cord-005453-4057qib7 2695 15 and and CC cord-005453-4057qib7 2695 16 overall overall JJ cord-005453-4057qib7 2695 17 survival survival NN cord-005453-4057qib7 2695 18 ( ( -LRB- cord-005453-4057qib7 2695 19 OS OS NNP cord-005453-4057qib7 2695 20 ) ) -RRB- cord-005453-4057qib7 2695 21 ] ] -RRB- cord-005453-4057qib7 2695 22 and and CC cord-005453-4057qib7 2695 23 harms harm NNS cord-005453-4057qib7 2695 24 ( ( -LRB- cord-005453-4057qib7 2695 25 hemorrhage hemorrhage NN cord-005453-4057qib7 2695 26 , , , cord-005453-4057qib7 2695 27 any any DT cord-005453-4057qib7 2695 28 site site NN cord-005453-4057qib7 2695 29 or or CC cord-005453-4057qib7 2695 30 organ organ NN cord-005453-4057qib7 2695 31 - - HYPH cord-005453-4057qib7 2695 32 specific specific JJ cord-005453-4057qib7 2695 33 ) ) -RRB- cord-005453-4057qib7 2695 34 . . . cord-005453-4057qib7 2696 1 A a DT cord-005453-4057qib7 2696 2 total total NN cord-005453-4057qib7 2696 3 of of IN cord-005453-4057qib7 2696 4 15 15 CD cord-005453-4057qib7 2696 5 studies study NNS cord-005453-4057qib7 2696 6 ( ( -LRB- cord-005453-4057qib7 2696 7 prospective=6 prospective=6 NN cord-005453-4057qib7 2696 8 ; ; : cord-005453-4057qib7 2696 9 retrospective=9 retrospective=9 LS cord-005453-4057qib7 2696 10 ) ) -RRB- cord-005453-4057qib7 2697 1 with with IN cord-005453-4057qib7 2697 2 1437 1437 CD cord-005453-4057qib7 2697 3 patients patient NNS cord-005453-4057qib7 2697 4 met meet VBD cord-005453-4057qib7 2697 5 inclusion inclusion NN cord-005453-4057qib7 2697 6 criteria criterion NNS cord-005453-4057qib7 2697 7 . . . cord-005453-4057qib7 2698 1 Results result NNS cord-005453-4057qib7 2698 2 : : : cord-005453-4057qib7 2699 1 The the DT cord-005453-4057qib7 2699 2 median median JJ cord-005453-4057qib7 2699 3 year year NN cord-005453-4057qib7 2699 4 of of IN cord-005453-4057qib7 2699 5 publication publication NN cord-005453-4057qib7 2699 6 of of IN cord-005453-4057qib7 2699 7 prospective prospective JJ cord-005453-4057qib7 2699 8 studies study NNS cord-005453-4057qib7 2699 9 was be VBD cord-005453-4057qib7 2699 10 2013 2013 CD cord-005453-4057qib7 2699 11 ( ( -LRB- cord-005453-4057qib7 2699 12 2002 2002 CD cord-005453-4057qib7 2699 13 ) ) -RRB- cord-005453-4057qib7 2700 1 ( ( -LRB- cord-005453-4057qib7 2700 2 2003 2003 CD cord-005453-4057qib7 2700 3 ) ) -RRB- cord-005453-4057qib7 2701 1 ( ( -LRB- cord-005453-4057qib7 2701 2 2004 2004 CD cord-005453-4057qib7 2701 3 ) ) -RRB- cord-005453-4057qib7 2702 1 ( ( -LRB- cord-005453-4057qib7 2702 2 2005 2005 CD cord-005453-4057qib7 2702 3 ) ) -RRB- cord-005453-4057qib7 2703 1 ( ( -LRB- cord-005453-4057qib7 2703 2 2006 2006 CD cord-005453-4057qib7 2703 3 ) ) -RRB- cord-005453-4057qib7 2704 1 ( ( -LRB- cord-005453-4057qib7 2704 2 2007 2007 CD cord-005453-4057qib7 2704 3 ) ) -RRB- cord-005453-4057qib7 2705 1 ( ( -LRB- cord-005453-4057qib7 2705 2 2008 2008 CD cord-005453-4057qib7 2705 3 ) ) -RRB- cord-005453-4057qib7 2706 1 ( ( -LRB- cord-005453-4057qib7 2706 2 2009 2009 CD cord-005453-4057qib7 2706 3 ) ) -RRB- cord-005453-4057qib7 2707 1 ( ( -LRB- cord-005453-4057qib7 2707 2 2010 2010 CD cord-005453-4057qib7 2707 3 ) ) -RRB- cord-005453-4057qib7 2708 1 ( ( -LRB- cord-005453-4057qib7 2708 2 2011 2011 CD cord-005453-4057qib7 2708 3 ) ) -RRB- cord-005453-4057qib7 2709 1 ( ( -LRB- cord-005453-4057qib7 2709 2 2012 2012 CD cord-005453-4057qib7 2709 3 ) ) -RRB- cord-005453-4057qib7 2710 1 ( ( -LRB- cord-005453-4057qib7 2710 2 2013 2013 CD cord-005453-4057qib7 2710 3 ) ) -RRB- cord-005453-4057qib7 2711 1 ( ( -LRB- cord-005453-4057qib7 2711 2 2014 2014 CD cord-005453-4057qib7 2711 3 ) ) -RRB- cord-005453-4057qib7 2711 4 ( ( -LRB- cord-005453-4057qib7 2711 5 2015 2015 CD cord-005453-4057qib7 2711 6 ) ) -RRB- cord-005453-4057qib7 2711 7 ( ( -LRB- cord-005453-4057qib7 2711 8 2016 2016 CD cord-005453-4057qib7 2711 9 ) ) -RRB- cord-005453-4057qib7 2711 10 ( ( -LRB- cord-005453-4057qib7 2711 11 2017 2017 CD cord-005453-4057qib7 2711 12 ) ) -RRB- cord-005453-4057qib7 2711 13 ( ( -LRB- cord-005453-4057qib7 2711 14 2018 2018 CD cord-005453-4057qib7 2711 15 ) ) -RRB- cord-005453-4057qib7 2712 1 and and CC cord-005453-4057qib7 2712 2 for for IN cord-005453-4057qib7 2712 3 retrospective retrospective JJ cord-005453-4057qib7 2712 4 ones one NNS cord-005453-4057qib7 2712 5 2016 2016 CD cord-005453-4057qib7 2712 6 ( ( -LRB- cord-005453-4057qib7 2712 7 2000 2000 CD cord-005453-4057qib7 2712 8 ) ) -RRB- cord-005453-4057qib7 2712 9 ( ( -LRB- cord-005453-4057qib7 2712 10 2001 2001 CD cord-005453-4057qib7 2712 11 ) ) -RRB- cord-005453-4057qib7 2712 12 ( ( -LRB- cord-005453-4057qib7 2712 13 2002 2002 CD cord-005453-4057qib7 2712 14 ) ) -RRB- cord-005453-4057qib7 2712 15 ( ( -LRB- cord-005453-4057qib7 2712 16 2003 2003 CD cord-005453-4057qib7 2712 17 ) ) -RRB- cord-005453-4057qib7 2712 18 ( ( -LRB- cord-005453-4057qib7 2712 19 2004 2004 CD cord-005453-4057qib7 2712 20 ) ) -RRB- cord-005453-4057qib7 2712 21 ( ( -LRB- cord-005453-4057qib7 2712 22 2005 2005 CD cord-005453-4057qib7 2712 23 ) ) -RRB- cord-005453-4057qib7 2712 24 ( ( -LRB- cord-005453-4057qib7 2712 25 2006 2006 CD cord-005453-4057qib7 2712 26 ) ) -RRB- cord-005453-4057qib7 2712 27 ( ( -LRB- cord-005453-4057qib7 2712 28 2007 2007 CD cord-005453-4057qib7 2712 29 ) ) -RRB- cord-005453-4057qib7 2712 30 ( ( -LRB- cord-005453-4057qib7 2712 31 2008 2008 CD cord-005453-4057qib7 2712 32 ) ) -RRB- cord-005453-4057qib7 2712 33 ( ( -LRB- cord-005453-4057qib7 2712 34 2009 2009 CD cord-005453-4057qib7 2712 35 ) ) -RRB- cord-005453-4057qib7 2712 36 ( ( -LRB- cord-005453-4057qib7 2712 37 2010 2010 CD cord-005453-4057qib7 2712 38 ) ) -RRB- cord-005453-4057qib7 2712 39 ( ( -LRB- cord-005453-4057qib7 2712 40 2011 2011 CD cord-005453-4057qib7 2712 41 ) ) -RRB- cord-005453-4057qib7 2712 42 ( ( -LRB- cord-005453-4057qib7 2712 43 2012 2012 CD cord-005453-4057qib7 2712 44 ) ) -RRB- cord-005453-4057qib7 2712 45 ( ( -LRB- cord-005453-4057qib7 2712 46 2013 2013 CD cord-005453-4057qib7 2712 47 ) ) -RRB- cord-005453-4057qib7 2713 1 ( ( -LRB- cord-005453-4057qib7 2713 2 2014 2014 CD cord-005453-4057qib7 2713 3 ) ) -RRB- cord-005453-4057qib7 2713 4 ( ( -LRB- cord-005453-4057qib7 2713 5 2015 2015 CD cord-005453-4057qib7 2713 6 ) ) -RRB- cord-005453-4057qib7 2713 7 ( ( -LRB- cord-005453-4057qib7 2713 8 2016 2016 CD cord-005453-4057qib7 2713 9 ) ) -RRB- cord-005453-4057qib7 2713 10 ( ( -LRB- cord-005453-4057qib7 2713 11 2017 2017 CD cord-005453-4057qib7 2713 12 ) ) -RRB- cord-005453-4057qib7 2713 13 ( ( -LRB- cord-005453-4057qib7 2713 14 2018 2018 CD cord-005453-4057qib7 2713 15 ) ) -RRB- cord-005453-4057qib7 2713 16 . . . cord-005453-4057qib7 2714 1 The the DT cord-005453-4057qib7 2714 2 prescribed prescribed JJ cord-005453-4057qib7 2714 3 starting starting NN cord-005453-4057qib7 2714 4 dose dose NN cord-005453-4057qib7 2714 5 of of IN cord-005453-4057qib7 2714 6 defibrotide defibrotide NN cord-005453-4057qib7 2714 7 varied varied JJ cord-005453-4057qib7 2714 8 among among IN cord-005453-4057qib7 2714 9 studies study NNS cord-005453-4057qib7 2714 10 ranging range VBG cord-005453-4057qib7 2714 11 from from IN cord-005453-4057qib7 2714 12 6.25 6.25 CD cord-005453-4057qib7 2714 13 mg mg NNP cord-005453-4057qib7 2714 14 / / SYM cord-005453-4057qib7 2714 15 kg kg NNP cord-005453-4057qib7 2714 16 / / SYM cord-005453-4057qib7 2714 17 day day NN cord-005453-4057qib7 2714 18 to to IN cord-005453-4057qib7 2714 19 80 80 CD cord-005453-4057qib7 2714 20 mg mg NNP cord-005453-4057qib7 2714 21 / / SYM cord-005453-4057qib7 2714 22 kg kg NNP cord-005453-4057qib7 2714 23 / / SYM cord-005453-4057qib7 2714 24 day day NN cord-005453-4057qib7 2714 25 , , , cord-005453-4057qib7 2714 26 mostly mostly RB cord-005453-4057qib7 2714 27 for for IN cord-005453-4057qib7 2714 28 a a DT cord-005453-4057qib7 2714 29 21-day 21-day CD cord-005453-4057qib7 2714 30 course course NN cord-005453-4057qib7 2714 31 . . . cord-005453-4057qib7 2715 1 The the DT cord-005453-4057qib7 2715 2 pooled pool VBN cord-005453-4057qib7 2715 3 CR cr NN cord-005453-4057qib7 2715 4 rate rate NN cord-005453-4057qib7 2715 5 was be VBD cord-005453-4057qib7 2715 6 39 39 CD cord-005453-4057qib7 2715 7 % % NN cord-005453-4057qib7 2715 8 ( ( -LRB- cord-005453-4057qib7 2715 9 95%CI=28 95%CI=28 NNP cord-005453-4057qib7 2715 10 - - SYM cord-005453-4057qib7 2715 11 49 49 CD cord-005453-4057qib7 2715 12 % % NN cord-005453-4057qib7 2715 13 ) ) -RRB- cord-005453-4057qib7 2715 14 for for IN cord-005453-4057qib7 2715 15 prospective prospective JJ cord-005453-4057qib7 2715 16 and and CC cord-005453-4057qib7 2715 17 54 54 CD cord-005453-4057qib7 2715 18 % % NN cord-005453-4057qib7 2715 19 ( ( -LRB- cord-005453-4057qib7 2715 20 95%CI=39 95%CI=39 NNP cord-005453-4057qib7 2715 21 - - SYM cord-005453-4057qib7 2715 22 69 69 CD cord-005453-4057qib7 2715 23 % % NN cord-005453-4057qib7 2715 24 ) ) -RRB- cord-005453-4057qib7 2715 25 for for IN cord-005453-4057qib7 2715 26 retrospective retrospective JJ cord-005453-4057qib7 2715 27 studies study NNS cord-005453-4057qib7 2715 28 . . . cord-005453-4057qib7 2716 1 The the DT cord-005453-4057qib7 2716 2 pooled pooled JJ cord-005453-4057qib7 2716 3 day day NN cord-005453-4057qib7 2716 4 +100 +100 NN cord-005453-4057qib7 2716 5 OS os NN cord-005453-4057qib7 2716 6 rates rate NNS cord-005453-4057qib7 2716 7 were be VBD cord-005453-4057qib7 2716 8 43 43 CD cord-005453-4057qib7 2716 9 % % NN cord-005453-4057qib7 2716 10 ( ( -LRB- cord-005453-4057qib7 2716 11 95%CI=37 95%CI=37 NNP cord-005453-4057qib7 2716 12 - - SYM cord-005453-4057qib7 2716 13 48 48 CD cord-005453-4057qib7 2716 14 % % NN cord-005453-4057qib7 2716 15 ) ) -RRB- cord-005453-4057qib7 2716 16 and and CC cord-005453-4057qib7 2716 17 65 65 CD cord-005453-4057qib7 2716 18 % % NN cord-005453-4057qib7 2716 19 ( ( -LRB- cord-005453-4057qib7 2716 20 95 95 CD cord-005453-4057qib7 2716 21 % % NN cord-005453-4057qib7 2716 22 CI=53 CI=53 NNP cord-005453-4057qib7 2716 23 - - HYPH cord-005453-4057qib7 2716 24 75 75 CD cord-005453-4057qib7 2716 25 % % NN cord-005453-4057qib7 2716 26 ) ) -RRB- cord-005453-4057qib7 2716 27 for for IN cord-005453-4057qib7 2716 28 prospective prospective JJ cord-005453-4057qib7 2716 29 and and CC cord-005453-4057qib7 2716 30 retrospective retrospective JJ cord-005453-4057qib7 2716 31 studies study NNS cord-005453-4057qib7 2716 32 , , , cord-005453-4057qib7 2716 33 respectively respectively RB cord-005453-4057qib7 2716 34 . . . cord-005453-4057qib7 2717 1 The the DT cord-005453-4057qib7 2717 2 pooled pool VBN cord-005453-4057qib7 2717 3 rates rate NNS cord-005453-4057qib7 2717 4 of of IN cord-005453-4057qib7 2717 5 hemorrhage hemorrhage NN cord-005453-4057qib7 2717 6 ( ( -LRB- cord-005453-4057qib7 2717 7 any any DT cord-005453-4057qib7 2717 8 site site NN cord-005453-4057qib7 2717 9 ) ) -RRB- cord-005453-4057qib7 2717 10 were be VBD cord-005453-4057qib7 2717 11 15 15 CD cord-005453-4057qib7 2717 12 % % NN cord-005453-4057qib7 2717 13 ( ( -LRB- cord-005453-4057qib7 2717 14 95%CI=2 95%ci=2 CD cord-005453-4057qib7 2717 15 - - SYM cord-005453-4057qib7 2717 16 35 35 CD cord-005453-4057qib7 2717 17 % % NN cord-005453-4057qib7 2717 18 ) ) -RRB- cord-005453-4057qib7 2717 19 for for IN cord-005453-4057qib7 2717 20 prospective prospective JJ cord-005453-4057qib7 2717 21 and and CC cord-005453-4057qib7 2717 22 21 21 CD cord-005453-4057qib7 2717 23 % % NN cord-005453-4057qib7 2717 24 ( ( -LRB- cord-005453-4057qib7 2717 25 95 95 CD cord-005453-4057qib7 2717 26 % % NN cord-005453-4057qib7 2717 27 CI=4 CI=4 NNPS cord-005453-4057qib7 2717 28 - - SYM cord-005453-4057qib7 2717 29 43 43 CD cord-005453-4057qib7 2717 30 % % NN cord-005453-4057qib7 2717 31 ) ) -RRB- cord-005453-4057qib7 2717 32 for for IN cord-005453-4057qib7 2717 33 retrospective retrospective JJ cord-005453-4057qib7 2717 34 studies study NNS cord-005453-4057qib7 2717 35 . . . cord-005453-4057qib7 2718 1 When when WRB cord-005453-4057qib7 2718 2 analyzing analyze VBG cord-005453-4057qib7 2718 3 organ organ NN cord-005453-4057qib7 2718 4 - - HYPH cord-005453-4057qib7 2718 5 specific specific JJ cord-005453-4057qib7 2718 6 hemorrhage hemorrhage NN cord-005453-4057qib7 2718 7 , , , cord-005453-4057qib7 2718 8 3 3 CD cord-005453-4057qib7 2718 9 prospective prospective JJ cord-005453-4057qib7 2718 10 studies study NNS cord-005453-4057qib7 2718 11 ( ( -LRB- cord-005453-4057qib7 2718 12 n=1091 n=1091 CD cord-005453-4057qib7 2718 13 patients patient NNS cord-005453-4057qib7 2718 14 ) ) -RRB- cord-005453-4057qib7 2718 15 reported report VBD cord-005453-4057qib7 2718 16 pooled pool VBN cord-005453-4057qib7 2718 17 rates rate NNS cord-005453-4057qib7 2718 18 of of IN cord-005453-4057qib7 2718 19 pulmonary pulmonary JJ cord-005453-4057qib7 2718 20 alveolar alveolar NN cord-005453-4057qib7 2718 21 ( ( -LRB- cord-005453-4057qib7 2718 22 PA PA NNP cord-005453-4057qib7 2718 23 ) ) -RRB- cord-005453-4057qib7 2718 24 hemorrhage hemorrhage NN cord-005453-4057qib7 2718 25 of of IN cord-005453-4057qib7 2718 26 2 2 CD cord-005453-4057qib7 2718 27 % % NN cord-005453-4057qib7 2718 28 ( ( -LRB- cord-005453-4057qib7 2718 29 95%CI=1 95%ci=1 CD cord-005453-4057qib7 2718 30 - - SYM cord-005453-4057qib7 2718 31 3 3 CD cord-005453-4057qib7 2718 32 % % NN cord-005453-4057qib7 2718 33 ) ) -RRB- cord-005453-4057qib7 2718 34 and and CC cord-005453-4057qib7 2718 35 of of IN cord-005453-4057qib7 2718 36 5 5 CD cord-005453-4057qib7 2718 37 % % NN cord-005453-4057qib7 2718 38 ( ( -LRB- cord-005453-4057qib7 2718 39 95%CI=3 95%ci=3 CD cord-005453-4057qib7 2718 40 - - SYM cord-005453-4057qib7 2718 41 7 7 CD cord-005453-4057qib7 2718 42 % % NN cord-005453-4057qib7 2718 43 ) ) -RRB- cord-005453-4057qib7 2718 44 for for IN cord-005453-4057qib7 2718 45 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 2718 46 ( ( -LRB- cord-005453-4057qib7 2718 47 GI gi NN cord-005453-4057qib7 2718 48 ) ) -RRB- cord-005453-4057qib7 2718 49 hemorrhage hemorrhage NN cord-005453-4057qib7 2718 50 . . . cord-005453-4057qib7 2719 1 Only only RB cord-005453-4057qib7 2719 2 one one CD cord-005453-4057qib7 2719 3 retrospective retrospective JJ cord-005453-4057qib7 2719 4 study study NN cord-005453-4057qib7 2719 5 ( ( -LRB- cord-005453-4057qib7 2719 6 n=14 n=14 JJ cord-005453-4057qib7 2719 7 patients patient NNS cord-005453-4057qib7 2719 8 ) ) -RRB- cord-005453-4057qib7 2719 9 reported report VBD cord-005453-4057qib7 2719 10 an an DT cord-005453-4057qib7 2719 11 incidence incidence NN cord-005453-4057qib7 2719 12 of of IN cord-005453-4057qib7 2719 13 PA PA NNP cord-005453-4057qib7 2719 14 hemorrhage hemorrhage NN cord-005453-4057qib7 2719 15 of of IN cord-005453-4057qib7 2719 16 7 7 CD cord-005453-4057qib7 2719 17 % % NN cord-005453-4057qib7 2719 18 ( ( -LRB- cord-005453-4057qib7 2719 19 95%CI=0 95%ci=0 CD cord-005453-4057qib7 2719 20 - - SYM cord-005453-4057qib7 2719 21 34 34 CD cord-005453-4057qib7 2719 22 % % NN cord-005453-4057qib7 2719 23 ) ) -RRB- cord-005453-4057qib7 2719 24 and and CC cord-005453-4057qib7 2719 25 a a DT cord-005453-4057qib7 2719 26 different different JJ cord-005453-4057qib7 2719 27 study study NN cord-005453-4057qib7 2719 28 ( ( -LRB- cord-005453-4057qib7 2719 29 n=14 n=14 JJ cord-005453-4057qib7 2719 30 patients patient NNS cord-005453-4057qib7 2719 31 ) ) -RRB- cord-005453-4057qib7 2719 32 reported report VBD cord-005453-4057qib7 2719 33 an an DT cord-005453-4057qib7 2719 34 incidence incidence NN cord-005453-4057qib7 2719 35 of of IN cord-005453-4057qib7 2719 36 GI GI NNP cord-005453-4057qib7 2719 37 hemorrhage hemorrhage NN cord-005453-4057qib7 2719 38 of of IN cord-005453-4057qib7 2719 39 14 14 CD cord-005453-4057qib7 2719 40 % % NN cord-005453-4057qib7 2719 41 ( ( -LRB- cord-005453-4057qib7 2719 42 95%CI=2 95%ci=2 CD cord-005453-4057qib7 2719 43 - - SYM cord-005453-4057qib7 2719 44 43 43 CD cord-005453-4057qib7 2719 45 % % NN cord-005453-4057qib7 2719 46 ) ) -RRB- cord-005453-4057qib7 2719 47 . . . cord-005453-4057qib7 2720 1 None none NN cord-005453-4057qib7 2720 2 of of IN cord-005453-4057qib7 2720 3 the the DT cord-005453-4057qib7 2720 4 15 15 CD cord-005453-4057qib7 2720 5 studies study NNS cord-005453-4057qib7 2720 6 reported report VBD cord-005453-4057qib7 2720 7 cerebral cerebral JJ cord-005453-4057qib7 2720 8 hemorrhage hemorrhage NN cord-005453-4057qib7 2720 9 as as IN cord-005453-4057qib7 2720 10 a a DT cord-005453-4057qib7 2720 11 complication complication NN cord-005453-4057qib7 2720 12 of of IN cord-005453-4057qib7 2720 13 defibrotide defibrotide NN cord-005453-4057qib7 2720 14 therapy therapy NN cord-005453-4057qib7 2720 15 . . . cord-005453-4057qib7 2721 1 Conclusions conclusion NNS cord-005453-4057qib7 2721 2 : : : cord-005453-4057qib7 2722 1 This this DT cord-005453-4057qib7 2722 2 systematic systematic JJ cord-005453-4057qib7 2722 3 review review NN cord-005453-4057qib7 2722 4 / / SYM cord-005453-4057qib7 2722 5 meta meta NNP cord-005453-4057qib7 2722 6 - - HYPH cord-005453-4057qib7 2722 7 analysis analysis NNP cord-005453-4057qib7 2722 8 confirms confirm VBZ cord-005453-4057qib7 2722 9 the the DT cord-005453-4057qib7 2722 10 efficacy efficacy NN cord-005453-4057qib7 2722 11 of of IN cord-005453-4057qib7 2722 12 defibrotide defibrotide NN cord-005453-4057qib7 2722 13 for for IN cord-005453-4057qib7 2722 14 treatment treatment NN cord-005453-4057qib7 2722 15 of of IN cord-005453-4057qib7 2722 16 VOD VOD NNP cord-005453-4057qib7 2722 17 / / SYM cord-005453-4057qib7 2722 18 SOS SOS NNP cord-005453-4057qib7 2722 19 with with IN cord-005453-4057qib7 2722 20 or or CC cord-005453-4057qib7 2722 21 without without IN cord-005453-4057qib7 2722 22 multiorgan multiorgan NNP cord-005453-4057qib7 2722 23 failure failure NN cord-005453-4057qib7 2722 24 , , , cord-005453-4057qib7 2722 25 yielding yield VBG cord-005453-4057qib7 2722 26 CR cr NN cord-005453-4057qib7 2722 27 rates rate NNS cord-005453-4057qib7 2722 28 of of IN cord-005453-4057qib7 2722 29 39 39 CD cord-005453-4057qib7 2722 30 - - SYM cord-005453-4057qib7 2722 31 54 54 CD cord-005453-4057qib7 2722 32 % % NN cord-005453-4057qib7 2722 33 and and CC cord-005453-4057qib7 2722 34 day day NN cord-005453-4057qib7 2722 35 +100 +100 NNS cord-005453-4057qib7 2722 36 OS os NN cord-005453-4057qib7 2722 37 rates rate NNS cord-005453-4057qib7 2722 38 of of IN cord-005453-4057qib7 2722 39 43 43 CD cord-005453-4057qib7 2722 40 - - SYM cord-005453-4057qib7 2722 41 65 65 CD cord-005453-4057qib7 2722 42 % % NN cord-005453-4057qib7 2722 43 . . . cord-005453-4057qib7 2723 1 The the DT cord-005453-4057qib7 2723 2 purportedly purportedly RB cord-005453-4057qib7 2723 3 higher high JJR cord-005453-4057qib7 2723 4 pooled pool VBN cord-005453-4057qib7 2723 5 CR CR NNP cord-005453-4057qib7 2723 6 and and CC cord-005453-4057qib7 2723 7 OS OS NNP cord-005453-4057qib7 2723 8 rates rate NNS cord-005453-4057qib7 2723 9 observed observe VBN cord-005453-4057qib7 2723 10 with with IN cord-005453-4057qib7 2723 11 retrospective retrospective JJ cord-005453-4057qib7 2723 12 ( ( -LRB- cord-005453-4057qib7 2723 13 vs. vs. FW cord-005453-4057qib7 2723 14 prospective prospective JJ cord-005453-4057qib7 2723 15 ) ) -RRB- cord-005453-4057qib7 2723 16 studies study NNS cord-005453-4057qib7 2723 17 are be VBP cord-005453-4057qib7 2723 18 likely likely JJ cord-005453-4057qib7 2723 19 due due IN cord-005453-4057qib7 2723 20 to to IN cord-005453-4057qib7 2723 21 assignment assignment NN cord-005453-4057qib7 2723 22 - - HYPH cord-005453-4057qib7 2723 23 bias bias NN cord-005453-4057qib7 2723 24 inherent inherent JJ cord-005453-4057qib7 2723 25 to to IN cord-005453-4057qib7 2723 26 observational observational JJ cord-005453-4057qib7 2723 27 studies study NNS cord-005453-4057qib7 2723 28 . . . cord-005453-4057qib7 2724 1 Moreover moreover RB cord-005453-4057qib7 2724 2 , , , cord-005453-4057qib7 2724 3 although although IN cord-005453-4057qib7 2724 4 the the DT cord-005453-4057qib7 2724 5 pooled pool VBN cord-005453-4057qib7 2724 6 hemorrhage hemorrhage NN cord-005453-4057qib7 2724 7 ( ( -LRB- cord-005453-4057qib7 2724 8 any any DT cord-005453-4057qib7 2724 9 site site NN cord-005453-4057qib7 2724 10 ) ) -RRB- cord-005453-4057qib7 2724 11 rates rate NNS cord-005453-4057qib7 2724 12 of of IN cord-005453-4057qib7 2724 13 15 15 CD cord-005453-4057qib7 2724 14 - - SYM cord-005453-4057qib7 2724 15 21 21 CD cord-005453-4057qib7 2724 16 % % NN cord-005453-4057qib7 2724 17 is be VBZ cord-005453-4057qib7 2724 18 considered consider VBN cord-005453-4057qib7 2724 19 proportionally proportionally RB cord-005453-4057qib7 2724 20 significant significant JJ cord-005453-4057qib7 2724 21 , , , cord-005453-4057qib7 2724 22 the the DT cord-005453-4057qib7 2724 23 pooled pool VBN cord-005453-4057qib7 2724 24 rates rate NNS cord-005453-4057qib7 2724 25 of of IN cord-005453-4057qib7 2724 26 PA PA NNP cord-005453-4057qib7 2724 27 and and CC cord-005453-4057qib7 2724 28 GI GI NNP cord-005453-4057qib7 2724 29 hemorrhage hemorrhage NN cord-005453-4057qib7 2724 30 were be VBD cord-005453-4057qib7 2724 31 ≤ ≤ NNS cord-005453-4057qib7 2724 32 5 5 CD cord-005453-4057qib7 2724 33 % % NN cord-005453-4057qib7 2724 34 , , , cord-005453-4057qib7 2724 35 in in IN cord-005453-4057qib7 2724 36 prospective prospective JJ cord-005453-4057qib7 2724 37 studies study NNS cord-005453-4057qib7 2724 38 . . . cord-005453-4057qib7 2725 1 Clinical clinical JJ cord-005453-4057qib7 2725 2 Trial Trial NNP cord-005453-4057qib7 2725 3 Registry Registry NNP cord-005453-4057qib7 2725 4 : : : cord-005453-4057qib7 2726 1 Not not RB cord-005453-4057qib7 2726 2 applicable applicable JJ cord-005453-4057qib7 2726 3 Disclosure disclosure NN cord-005453-4057qib7 2726 4 : : : cord-005453-4057qib7 2726 5 M.A.K M.A.K NNP cord-005453-4057qib7 2726 6 - - HYPH cord-005453-4057qib7 2726 7 D D NNP cord-005453-4057qib7 2726 8 : : : cord-005453-4057qib7 2726 9 Consultancy consultancy NN cord-005453-4057qib7 2726 10 for for IN cord-005453-4057qib7 2726 11 Pharmacyclics Pharmacyclics NNP cord-005453-4057qib7 2726 12 M.M M.M NNP cord-005453-4057qib7 2726 13 : : : cord-005453-4057qib7 2726 14 received receive VBN cord-005453-4057qib7 2726 15 lectures lecture NNS cord-005453-4057qib7 2726 16 honoraria honorarium NNS cord-005453-4057qib7 2726 17 and and CC cord-005453-4057qib7 2726 18 research research NN cord-005453-4057qib7 2726 19 support support NN cord-005453-4057qib7 2726 20 from from IN cord-005453-4057qib7 2726 21 Jazz Jazz NNP cord-005453-4057qib7 2726 22 Pharma Pharma NNP cord-005453-4057qib7 2726 23 Efficacy Efficacy NNP cord-005453-4057qib7 2726 24 and and CC cord-005453-4057qib7 2726 25 safety safety NN cord-005453-4057qib7 2726 26 of of IN cord-005453-4057qib7 2726 27 defibrotide defibrotide NN cord-005453-4057qib7 2726 28 in in IN cord-005453-4057qib7 2726 29 the the DT cord-005453-4057qib7 2726 30 treatment treatment NN cord-005453-4057qib7 2726 31 of of IN cord-005453-4057qib7 2726 32 hepatic hepatic JJ cord-005453-4057qib7 2726 33 veno veno NN cord-005453-4057qib7 2726 34 - - HYPH cord-005453-4057qib7 2726 35 occlusive occlusive JJ cord-005453-4057qib7 2726 36 disease disease NN cord-005453-4057qib7 2726 37 / / , cord-005453-4057qib7 2726 38 sinusoidal sinusoidal JJ cord-005453-4057qib7 2726 39 obstruction obstruction NN cord-005453-4057qib7 2726 40 syndrome syndrome NN cord-005453-4057qib7 2726 41 following follow VBG cord-005453-4057qib7 2726 42 hematopoietic hematopoietic JJ cord-005453-4057qib7 2726 43 stem stem NN cord-005453-4057qib7 2726 44 cell cell NN cord-005453-4057qib7 2726 45 transplantation transplantation NN cord-005453-4057qib7 2726 46 : : : cord-005453-4057qib7 2727 1 Interim interim JJ cord-005453-4057qib7 2727 2 results result NNS cord-005453-4057qib7 2727 3 from from IN cord-005453-4057qib7 2727 4 the the DT cord-005453-4057qib7 2727 5 defifrance defifrance NN cord-005453-4057qib7 2727 6 study study NN cord-005453-4057qib7 2727 7 Background Background NNP cord-005453-4057qib7 2727 8 : : : cord-005453-4057qib7 2728 1 Hepatic hepatic JJ cord-005453-4057qib7 2728 2 veno veno NN cord-005453-4057qib7 2728 3 - - HYPH cord-005453-4057qib7 2728 4 occlusive occlusive JJ cord-005453-4057qib7 2728 5 disease disease NN cord-005453-4057qib7 2728 6 / / , cord-005453-4057qib7 2728 7 sinusoidal sinusoidal JJ cord-005453-4057qib7 2728 8 obstruction obstruction NN cord-005453-4057qib7 2728 9 syndrome syndrome NN cord-005453-4057qib7 2728 10 ( ( -LRB- cord-005453-4057qib7 2728 11 VOD VOD NNP cord-005453-4057qib7 2728 12 / / SYM cord-005453-4057qib7 2728 13 SOS SOS NNP cord-005453-4057qib7 2728 14 ) ) -RRB- cord-005453-4057qib7 2728 15 is be VBZ cord-005453-4057qib7 2728 16 a a DT cord-005453-4057qib7 2728 17 potentially potentially RB cord-005453-4057qib7 2728 18 lifethreatening lifethreatening JJ cord-005453-4057qib7 2728 19 complication complication NN cord-005453-4057qib7 2728 20 of of IN cord-005453-4057qib7 2728 21 conditioning conditioning NN cord-005453-4057qib7 2728 22 for for IN cord-005453-4057qib7 2728 23 hematopoietic hematopoietic JJ cord-005453-4057qib7 2728 24 stem stem NN cord-005453-4057qib7 2728 25 cell cell NN cord-005453-4057qib7 2728 26 transplant transplant NN cord-005453-4057qib7 2728 27 ( ( -LRB- cord-005453-4057qib7 2728 28 HSCT HSCT NNP cord-005453-4057qib7 2728 29 ) ) -RRB- cord-005453-4057qib7 2728 30 but but CC cord-005453-4057qib7 2728 31 may may MD cord-005453-4057qib7 2728 32 occur occur VB cord-005453-4057qib7 2728 33 after after IN cord-005453-4057qib7 2728 34 nontransplant nontransplant JJ cord-005453-4057qib7 2728 35 chemotherapy chemotherapy NN cord-005453-4057qib7 2728 36 alone alone RB cord-005453-4057qib7 2728 37 . . . cord-005453-4057qib7 2729 1 VOD VOD NNP cord-005453-4057qib7 2729 2 / / SYM cord-005453-4057qib7 2729 3 SOS SOS NNP cord-005453-4057qib7 2729 4 with with IN cord-005453-4057qib7 2729 5 multi multi JJ cord-005453-4057qib7 2729 6 - - JJ cord-005453-4057qib7 2729 7 organ organ JJ cord-005453-4057qib7 2729 8 dysfunction dysfunction NN cord-005453-4057qib7 2729 9 ( ( -LRB- cord-005453-4057qib7 2729 10 MOD mod NN cord-005453-4057qib7 2729 11 ) ) -RRB- cord-005453-4057qib7 2729 12 may may MD cord-005453-4057qib7 2729 13 be be VB cord-005453-4057qib7 2729 14 associated associate VBN cord-005453-4057qib7 2729 15 with with IN cord-005453-4057qib7 2729 16 > > XX cord-005453-4057qib7 2729 17 80 80 CD cord-005453-4057qib7 2729 18 % % NN cord-005453-4057qib7 2729 19 mortality mortality NN cord-005453-4057qib7 2729 20 with with IN cord-005453-4057qib7 2729 21 supportive supportive JJ cord-005453-4057qib7 2729 22 care care NN cord-005453-4057qib7 2729 23 alone alone RB cord-005453-4057qib7 2729 24 . . . cord-005453-4057qib7 2730 1 Diagnosis diagnosis NN cord-005453-4057qib7 2730 2 of of IN cord-005453-4057qib7 2730 3 VOD VOD NNP cord-005453-4057qib7 2730 4 / / SYM cord-005453-4057qib7 2730 5 SOS SOS NNP cord-005453-4057qib7 2730 6 was be VBD cord-005453-4057qib7 2730 7 traditionally traditionally RB cord-005453-4057qib7 2730 8 based base VBN cord-005453-4057qib7 2730 9 on on IN cord-005453-4057qib7 2730 10 Baltimore Baltimore NNP cord-005453-4057qib7 2730 11 or or CC cord-005453-4057qib7 2730 12 modified modify VBN cord-005453-4057qib7 2730 13 Seattle Seattle NNP cord-005453-4057qib7 2730 14 criteria criterion NNS cord-005453-4057qib7 2730 15 ; ; : cord-005453-4057qib7 2730 16 however however RB cord-005453-4057qib7 2730 17 , , , cord-005453-4057qib7 2730 18 the the DT cord-005453-4057qib7 2730 19 EBMT EBMT NNP cord-005453-4057qib7 2730 20 recently recently RB cord-005453-4057qib7 2730 21 published publish VBD cord-005453-4057qib7 2730 22 separate separate JJ cord-005453-4057qib7 2730 23 diagnostic diagnostic JJ cord-005453-4057qib7 2730 24 criteria criterion NNS cord-005453-4057qib7 2730 25 for for IN cord-005453-4057qib7 2730 26 adults adult NNS cord-005453-4057qib7 2730 27 and and CC cord-005453-4057qib7 2730 28 children child NNS cord-005453-4057qib7 2730 29 . . . cord-005453-4057qib7 2731 1 Defibrotide Defibrotide NNP cord-005453-4057qib7 2731 2 is be VBZ cord-005453-4057qib7 2731 3 approved approve VBN cord-005453-4057qib7 2731 4 for for IN cord-005453-4057qib7 2731 5 treating treat VBG cord-005453-4057qib7 2731 6 severe severe JJ cord-005453-4057qib7 2731 7 hepatic hepatic JJ cord-005453-4057qib7 2731 8 VOD VOD NNP cord-005453-4057qib7 2731 9 / / SYM cord-005453-4057qib7 2731 10 SOS SOS NNP cord-005453-4057qib7 2731 11 post post NNP cord-005453-4057qib7 2731 12 - - JJ cord-005453-4057qib7 2731 13 HSCT HSCT NNP cord-005453-4057qib7 2731 14 in in IN cord-005453-4057qib7 2731 15 patients patient NNS cord-005453-4057qib7 2731 16 aged age VBN cord-005453-4057qib7 2731 17 > > SYM cord-005453-4057qib7 2731 18 1 1 CD cord-005453-4057qib7 2731 19 month month NN cord-005453-4057qib7 2731 20 in in IN cord-005453-4057qib7 2731 21 the the DT cord-005453-4057qib7 2731 22 EU EU NNP cord-005453-4057qib7 2731 23 , , , cord-005453-4057qib7 2731 24 and and CC cord-005453-4057qib7 2731 25 for for IN cord-005453-4057qib7 2731 26 hepatic hepatic JJ cord-005453-4057qib7 2731 27 VOD VOD NNP cord-005453-4057qib7 2731 28 / / SYM cord-005453-4057qib7 2731 29 SOS SOS NNP cord-005453-4057qib7 2731 30 with with IN cord-005453-4057qib7 2731 31 renal renal JJ cord-005453-4057qib7 2731 32 or or CC cord-005453-4057qib7 2731 33 pulmonary pulmonary JJ cord-005453-4057qib7 2731 34 dysfunction dysfunction NN cord-005453-4057qib7 2731 35 post post NN cord-005453-4057qib7 2731 36 - - JJ cord-005453-4057qib7 2731 37 HSCT HSCT NNP cord-005453-4057qib7 2731 38 in in IN cord-005453-4057qib7 2731 39 the the DT cord-005453-4057qib7 2731 40 USA USA NNP cord-005453-4057qib7 2731 41 . . . cord-005453-4057qib7 2732 1 The the DT cord-005453-4057qib7 2732 2 goal goal NN cord-005453-4057qib7 2732 3 of of IN cord-005453-4057qib7 2732 4 the the DT cord-005453-4057qib7 2732 5 DEFIFRANCE DEFIFRANCE NNP cord-005453-4057qib7 2732 6 study study NN cord-005453-4057qib7 2732 7 , , , cord-005453-4057qib7 2732 8 requested request VBN cord-005453-4057qib7 2732 9 by by IN cord-005453-4057qib7 2732 10 the the DT cord-005453-4057qib7 2732 11 French french JJ cord-005453-4057qib7 2732 12 health health NN cord-005453-4057qib7 2732 13 authorities authority NNS cord-005453-4057qib7 2732 14 , , , cord-005453-4057qib7 2732 15 is be VBZ cord-005453-4057qib7 2732 16 to to TO cord-005453-4057qib7 2732 17 collect collect VB cord-005453-4057qib7 2732 18 real real JJ cord-005453-4057qib7 2732 19 - - HYPH cord-005453-4057qib7 2732 20 world world NN cord-005453-4057qib7 2732 21 data datum NNS cord-005453-4057qib7 2732 22 on on IN cord-005453-4057qib7 2732 23 safety safety NN cord-005453-4057qib7 2732 24 and and CC cord-005453-4057qib7 2732 25 efficacy efficacy NN cord-005453-4057qib7 2732 26 in in IN cord-005453-4057qib7 2732 27 a a DT cord-005453-4057qib7 2732 28 broader broad JJR cord-005453-4057qib7 2732 29 patient patient JJ cord-005453-4057qib7 2732 30 population population NN cord-005453-4057qib7 2732 31 in in IN cord-005453-4057qib7 2732 32 France France NNP cord-005453-4057qib7 2732 33 , , , cord-005453-4057qib7 2732 34 including include VBG cord-005453-4057qib7 2732 35 all all DT cord-005453-4057qib7 2732 36 indications indication NNS cord-005453-4057qib7 2732 37 . . . cord-005453-4057qib7 2733 1 This this DT cord-005453-4057qib7 2733 2 is be VBZ cord-005453-4057qib7 2733 3 the the DT cord-005453-4057qib7 2733 4 first first JJ cord-005453-4057qib7 2733 5 interim interim JJ cord-005453-4057qib7 2733 6 analysis analysis NN cord-005453-4057qib7 2733 7 of of IN cord-005453-4057qib7 2733 8 the the DT cord-005453-4057qib7 2733 9 largest large JJS cord-005453-4057qib7 2733 10 current current JJ cord-005453-4057qib7 2733 11 evaluation evaluation NN cord-005453-4057qib7 2733 12 of of IN cord-005453-4057qib7 2733 13 defibrotide defibrotide NN cord-005453-4057qib7 2733 14 for for IN cord-005453-4057qib7 2733 15 the the DT cord-005453-4057qib7 2733 16 treatment treatment NN cord-005453-4057qib7 2733 17 of of IN cord-005453-4057qib7 2733 18 VOD VOD NNP cord-005453-4057qib7 2733 19 / / SYM cord-005453-4057qib7 2733 20 SOS SOS NNP cord-005453-4057qib7 2733 21 in in IN cord-005453-4057qib7 2733 22 Europe Europe NNP cord-005453-4057qib7 2733 23 . . . cord-005453-4057qib7 2734 1 Methods method NNS cord-005453-4057qib7 2734 2 : : : cord-005453-4057qib7 2734 3 DEFIFRANCE DEFIFRANCE NNP cord-005453-4057qib7 2734 4 is be VBZ cord-005453-4057qib7 2734 5 an an DT cord-005453-4057qib7 2734 6 observational observational JJ cord-005453-4057qib7 2734 7 , , , cord-005453-4057qib7 2734 8 multicenter multicenter JJ cord-005453-4057qib7 2734 9 , , , cord-005453-4057qib7 2734 10 post post JJ cord-005453-4057qib7 2734 11 - - JJ cord-005453-4057qib7 2734 12 marketing marketing JJ cord-005453-4057qib7 2734 13 study study NN cord-005453-4057qib7 2734 14 that that WDT cord-005453-4057qib7 2734 15 includes include VBZ cord-005453-4057qib7 2734 16 any any DT cord-005453-4057qib7 2734 17 patient patient NN cord-005453-4057qib7 2734 18 treated treat VBN cord-005453-4057qib7 2734 19 with with IN cord-005453-4057qib7 2734 20 defibrotide defibrotide NN cord-005453-4057qib7 2734 21 from from IN cord-005453-4057qib7 2734 22 HSCT HSCT NNP cord-005453-4057qib7 2734 23 centers center NNS cord-005453-4057qib7 2734 24 in in IN cord-005453-4057qib7 2734 25 France France NNP cord-005453-4057qib7 2734 26 . . . cord-005453-4057qib7 2735 1 This this DT cord-005453-4057qib7 2735 2 interim interim JJ cord-005453-4057qib7 2735 3 analysis analysis NN cord-005453-4057qib7 2735 4 is be VBZ cord-005453-4057qib7 2735 5 based base VBN cord-005453-4057qib7 2735 6 on on IN cord-005453-4057qib7 2735 7 all all DT cord-005453-4057qib7 2735 8 patients patient NNS cord-005453-4057qib7 2735 9 treated treat VBN cord-005453-4057qib7 2735 10 with with IN cord-005453-4057qib7 2735 11 defibrotide defibrotide NN cord-005453-4057qib7 2735 12 , , , cord-005453-4057qib7 2735 13 including include VBG cord-005453-4057qib7 2735 14 those those DT cord-005453-4057qib7 2735 15 with with IN cord-005453-4057qib7 2735 16 severe severe JJ cord-005453-4057qib7 2735 17 and and CC cord-005453-4057qib7 2735 18 very very RB cord-005453-4057qib7 2735 19 severe severe JJ cord-005453-4057qib7 2735 20 post post JJ cord-005453-4057qib7 2735 21 - - JJ cord-005453-4057qib7 2735 22 HSCT hsct JJ cord-005453-4057qib7 2735 23 VOD VOD NNP cord-005453-4057qib7 2735 24 / / SYM cord-005453-4057qib7 2735 25 SOS SOS NNP cord-005453-4057qib7 2735 26 . . . cord-005453-4057qib7 2736 1 VOD VOD NNP cord-005453-4057qib7 2736 2 / / SYM cord-005453-4057qib7 2736 3 SOS SOS NNP cord-005453-4057qib7 2736 4 was be VBD cord-005453-4057qib7 2736 5 diagnosed diagnose VBN cord-005453-4057qib7 2736 6 using use VBG cord-005453-4057qib7 2736 7 traditional traditional JJ cord-005453-4057qib7 2736 8 criteria criterion NNS cord-005453-4057qib7 2736 9 . . . cord-005453-4057qib7 2737 1 Day+100 Day+100 NNP cord-005453-4057qib7 2738 1 survival survival NN cord-005453-4057qib7 2738 2 , , , cord-005453-4057qib7 2738 3 complete complete JJ cord-005453-4057qib7 2738 4 remission remission NN cord-005453-4057qib7 2738 5 ( ( -LRB- cord-005453-4057qib7 2738 6 CR cr NN cord-005453-4057qib7 2738 7 ; ; : cord-005453-4057qib7 2738 8 total total JJ cord-005453-4057qib7 2738 9 serum serum NN cord-005453-4057qib7 2738 10 bilirubin bilirubin NN cord-005453-4057qib7 2738 11 < < XX cord-005453-4057qib7 2738 12 2 2 CD cord-005453-4057qib7 2738 13 mg mg NNP cord-005453-4057qib7 2738 14 / / SYM cord-005453-4057qib7 2738 15 dL dl NN cord-005453-4057qib7 2738 16 and and CC cord-005453-4057qib7 2738 17 resolution resolution NN cord-005453-4057qib7 2738 18 of of IN cord-005453-4057qib7 2738 19 MOD mod NN cord-005453-4057qib7 2738 20 ) ) -RRB- cord-005453-4057qib7 2738 21 , , , cord-005453-4057qib7 2738 22 and and CC cord-005453-4057qib7 2738 23 safety safety NN cord-005453-4057qib7 2738 24 profile profile NN cord-005453-4057qib7 2738 25 are be VBP cord-005453-4057qib7 2738 26 reported report VBN cord-005453-4057qib7 2738 27 . . . cord-005453-4057qib7 2739 1 Results result NNS cord-005453-4057qib7 2739 2 : : : cord-005453-4057qib7 2740 1 A a DT cord-005453-4057qib7 2740 2 total total NN cord-005453-4057qib7 2740 3 of of IN cord-005453-4057qib7 2740 4 324 324 CD cord-005453-4057qib7 2740 5 patients patient NNS cord-005453-4057qib7 2740 6 treated treat VBN cord-005453-4057qib7 2740 7 with with IN cord-005453-4057qib7 2740 8 defibrotide defibrotide NNP cord-005453-4057qib7 2740 9 were be VBD cord-005453-4057qib7 2740 10 included include VBN cord-005453-4057qib7 2740 11 retrospectively retrospectively RB cord-005453-4057qib7 2740 12 and and CC cord-005453-4057qib7 2740 13 prospectively prospectively RB cord-005453-4057qib7 2740 14 between between IN cord-005453-4057qib7 2740 15 July July NNP cord-005453-4057qib7 2740 16 2014 2014 CD cord-005453-4057qib7 2740 17 and and CC cord-005453-4057qib7 2740 18 October October NNP cord-005453-4057qib7 2740 19 2018 2018 CD cord-005453-4057qib7 2740 20 from from IN cord-005453-4057qib7 2740 21 36 36 CD cord-005453-4057qib7 2740 22 Table table NN cord-005453-4057qib7 2740 23 ] ] -RRB- cord-005453-4057qib7 2741 1 Disclosure disclosure NN cord-005453-4057qib7 2741 2 : : : cord-005453-4057qib7 2742 1 Mohamad Mohamad NNP cord-005453-4057qib7 2742 2 Mohty Mohty NNP cord-005453-4057qib7 2742 3 : : : cord-005453-4057qib7 2742 4 has have VBZ cord-005453-4057qib7 2742 5 received receive VBN cord-005453-4057qib7 2742 6 honoraria honorarium NNS cord-005453-4057qib7 2742 7 and and CC cord-005453-4057qib7 2742 8 research research NN cord-005453-4057qib7 2742 9 funding funding NN cord-005453-4057qib7 2742 10 from from IN cord-005453-4057qib7 2742 11 Jazz Jazz NNP cord-005453-4057qib7 2742 12 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 13 , , , cord-005453-4057qib7 2742 14 Delphine Delphine NNP cord-005453-4057qib7 2742 15 Lebon Lebon NNP cord-005453-4057qib7 2742 16 : : : cord-005453-4057qib7 2742 17 nothing nothing NN cord-005453-4057qib7 2742 18 to to TO cord-005453-4057qib7 2742 19 disclose disclose VB cord-005453-4057qib7 2742 20 , , , cord-005453-4057qib7 2742 21 Ann Ann NNP cord-005453-4057qib7 2742 22 Berceanu Berceanu NNP cord-005453-4057qib7 2742 23 : : : cord-005453-4057qib7 2742 24 none none NN cord-005453-4057qib7 2742 25 , , , cord-005453-4057qib7 2742 26 Charlotte Charlotte NNP cord-005453-4057qib7 2742 27 Jubert Jubert NNP cord-005453-4057qib7 2742 28 : : : cord-005453-4057qib7 2742 29 has have VBZ cord-005453-4057qib7 2742 30 received receive VBN cord-005453-4057qib7 2742 31 funding funding NN cord-005453-4057qib7 2742 32 from from IN cord-005453-4057qib7 2742 33 Jazz Jazz NNP cord-005453-4057qib7 2742 34 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 35 , , , cord-005453-4057qib7 2742 36 Ibrahim Ibrahim NNP cord-005453-4057qib7 2742 37 Yakoub Yakoub NNP cord-005453-4057qib7 2742 38 - - HYPH cord-005453-4057qib7 2742 39 Agha Agha NNP cord-005453-4057qib7 2742 40 : : : cord-005453-4057qib7 2742 41 has have VBZ cord-005453-4057qib7 2742 42 received receive VBN cord-005453-4057qib7 2742 43 honoraria honorarium NNS cord-005453-4057qib7 2742 44 from from IN cord-005453-4057qib7 2742 45 Jazz Jazz NNP cord-005453-4057qib7 2742 46 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 47 , , , cord-005453-4057qib7 2742 48 Stéphane Stéphane NNP cord-005453-4057qib7 2742 49 Girault Girault NNP cord-005453-4057qib7 2742 50 : : : cord-005453-4057qib7 2742 51 none none NN cord-005453-4057qib7 2742 52 , , , cord-005453-4057qib7 2742 53 Marie Marie NNP cord-005453-4057qib7 2742 54 Detrait Detrait NNP cord-005453-4057qib7 2742 55 : : : cord-005453-4057qib7 2742 56 has have VBZ cord-005453-4057qib7 2742 57 received receive VBN cord-005453-4057qib7 2742 58 research research NN cord-005453-4057qib7 2742 59 funding funding NN cord-005453-4057qib7 2742 60 from from IN cord-005453-4057qib7 2742 61 Jazz Jazz NNP cord-005453-4057qib7 2742 62 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 63 , , , cord-005453-4057qib7 2742 64 Cécile Cécile NNP cord-005453-4057qib7 2742 65 Pochon Pochon NNP cord-005453-4057qib7 2742 66 : : : cord-005453-4057qib7 2742 67 none none NN cord-005453-4057qib7 2742 68 , , , cord-005453-4057qib7 2742 69 Fanny Fanny NNP cord-005453-4057qib7 2742 70 Rialland Rialland NNP cord-005453-4057qib7 2742 71 : : : cord-005453-4057qib7 2742 72 none none NN cord-005453-4057qib7 2742 73 , , , cord-005453-4057qib7 2742 74 Virginie Virginie NNP cord-005453-4057qib7 2742 75 Gandemer Gandemer NNP cord-005453-4057qib7 2742 76 : : : cord-005453-4057qib7 2742 77 none none NN cord-005453-4057qib7 2742 78 , , , cord-005453-4057qib7 2742 79 Jean Jean NNP cord-005453-4057qib7 2742 80 - - HYPH cord-005453-4057qib7 2742 81 Hugues Hugues NNP cord-005453-4057qib7 2742 82 Dalle Dalle NNP cord-005453-4057qib7 2742 83 : : : cord-005453-4057qib7 2742 84 has have VBZ cord-005453-4057qib7 2742 85 received receive VBN cord-005453-4057qib7 2742 86 honoraria honorarium NNS cord-005453-4057qib7 2742 87 from from IN cord-005453-4057qib7 2742 88 Jazz Jazz NNP cord-005453-4057qib7 2742 89 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 90 , , , cord-005453-4057qib7 2742 91 Régis Régis NNP cord-005453-4057qib7 2742 92 Peffault Peffault NNP cord-005453-4057qib7 2742 93 de de NNP cord-005453-4057qib7 2742 94 Latour Latour NNP cord-005453-4057qib7 2742 95 : : : cord-005453-4057qib7 2742 96 has have VBZ cord-005453-4057qib7 2742 97 received receive VBN cord-005453-4057qib7 2742 98 research research NN cord-005453-4057qib7 2742 99 grant grant NN cord-005453-4057qib7 2742 100 / / SYM cord-005453-4057qib7 2742 101 honoraria honoraria NNP cord-005453-4057qib7 2742 102 / / SYM cord-005453-4057qib7 2742 103 board board NN cord-005453-4057qib7 2742 104 from from IN cord-005453-4057qib7 2742 105 Pfizer Pfizer NNP cord-005453-4057qib7 2742 106 , , , cord-005453-4057qib7 2742 107 Novartis Novartis NNP cord-005453-4057qib7 2742 108 , , , cord-005453-4057qib7 2742 109 Alexion Alexion NNP cord-005453-4057qib7 2742 110 ; ; : cord-005453-4057qib7 2742 111 research research NN cord-005453-4057qib7 2742 112 grant grant VBP cord-005453-4057qib7 2742 113 Amgen Amgen NNP cord-005453-4057qib7 2742 114 ; ; : cord-005453-4057qib7 2742 115 and and CC cord-005453-4057qib7 2742 116 honoraria honorarium NNS cord-005453-4057qib7 2742 117 from from IN cord-005453-4057qib7 2742 118 Jazz Jazz NNP cord-005453-4057qib7 2742 119 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 120 , , , cord-005453-4057qib7 2742 121 David David NNP cord-005453-4057qib7 2742 122 Michonneau Michonneau NNP cord-005453-4057qib7 2742 123 : : : cord-005453-4057qib7 2742 124 has have VBZ cord-005453-4057qib7 2742 125 received receive VBN cord-005453-4057qib7 2742 126 honoraria honorarium NNS cord-005453-4057qib7 2742 127 from from IN cord-005453-4057qib7 2742 128 Jazz Jazz NNP cord-005453-4057qib7 2742 129 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 130 , , , cord-005453-4057qib7 2742 131 Myriam Myriam NNP cord-005453-4057qib7 2742 132 Labopin Labopin NNP cord-005453-4057qib7 2742 133 : : : cord-005453-4057qib7 2742 134 has have VBZ cord-005453-4057qib7 2742 135 received receive VBN cord-005453-4057qib7 2742 136 honoraria honorarium NNS cord-005453-4057qib7 2742 137 from from IN cord-005453-4057qib7 2742 138 Jazz Jazz NNP cord-005453-4057qib7 2742 139 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 140 , , , cord-005453-4057qib7 2742 141 Floriane Floriane NNP cord-005453-4057qib7 2742 142 Delaval Delaval NNP cord-005453-4057qib7 2742 143 : : : cord-005453-4057qib7 2742 144 employee employee NN cord-005453-4057qib7 2742 145 of of IN cord-005453-4057qib7 2742 146 Jazz Jazz NNP cord-005453-4057qib7 2742 147 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 148 and and CC cord-005453-4057qib7 2742 149 holds hold VBZ cord-005453-4057qib7 2742 150 stock stock NN cord-005453-4057qib7 2742 151 and/or and/or CC cord-005453-4057qib7 2742 152 stock stock NN cord-005453-4057qib7 2742 153 options option NNS cord-005453-4057qib7 2742 154 in in IN cord-005453-4057qib7 2742 155 Jazz Jazz NNP cord-005453-4057qib7 2742 156 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 2742 157 plc plc NNP cord-005453-4057qib7 2742 158 , , , cord-005453-4057qib7 2742 159 Gerard Gerard NNP cord-005453-4057qib7 2742 160 Michel Michel NNP cord-005453-4057qib7 2742 161 : : : cord-005453-4057qib7 2742 162 none none NN cord-005453-4057qib7 2742 163 , , , cord-005453-4057qib7 2742 164 Anne Anne NNP cord-005453-4057qib7 2742 165 Sirvent Sirvent NNP cord-005453-4057qib7 2742 166 : : : cord-005453-4057qib7 2742 167 none none NN cord-005453-4057qib7 2742 168 , , , cord-005453-4057qib7 2742 169 Laurence Laurence NNP cord-005453-4057qib7 2742 170 Clement Clement NNP cord-005453-4057qib7 2742 171 : : : cord-005453-4057qib7 2742 172 none none NN cord-005453-4057qib7 2742 173 Anne Anne NNP cord-005453-4057qib7 2742 174 - - HYPH cord-005453-4057qib7 2742 175 Lise Lise NNP cord-005453-4057qib7 2742 176 Menard Menard NNP cord-005453-4057qib7 2742 177 : : : cord-005453-4057qib7 2742 178 none none NN cord-005453-4057qib7 2742 179 , , , cord-005453-4057qib7 2742 180 Anne Anne NNP cord-005453-4057qib7 2742 181 Huynh Huynh NNP cord-005453-4057qib7 2742 182 : : : cord-005453-4057qib7 2742 183 has have VBZ cord-005453-4057qib7 2742 184 received receive VBN cord-005453-4057qib7 2742 185 honoraria honorarium NNS cord-005453-4057qib7 2742 186 from from IN cord-005453-4057qib7 2742 187 Jazz Jazz NNP cord-005453-4057qib7 2742 188 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 189 , , , cord-005453-4057qib7 2742 190 Virginie Virginie NNP cord-005453-4057qib7 2742 191 Bouvatier Bouvatier NNP cord-005453-4057qib7 2742 192 : : : cord-005453-4057qib7 2742 193 employee employee NN cord-005453-4057qib7 2742 194 of of IN cord-005453-4057qib7 2742 195 Jazz Jazz NNP cord-005453-4057qib7 2742 196 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 197 and and CC cord-005453-4057qib7 2742 198 holds hold VBZ cord-005453-4057qib7 2742 199 stock stock NN cord-005453-4057qib7 2742 200 and/or and/or CC cord-005453-4057qib7 2742 201 stock stock NN cord-005453-4057qib7 2742 202 options option NNS cord-005453-4057qib7 2742 203 in in IN cord-005453-4057qib7 2742 204 Jazz Jazz NNP cord-005453-4057qib7 2742 205 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 2742 206 plc plc NNP cord-005453-4057qib7 2742 207 , , , cord-005453-4057qib7 2742 208 Raj Raj NNP cord-005453-4057qib7 2742 209 Hanvesakul Hanvesakul NNP cord-005453-4057qib7 2742 210 : : : cord-005453-4057qib7 2742 211 employee employee NN cord-005453-4057qib7 2742 212 of of IN cord-005453-4057qib7 2742 213 Jazz Jazz NNP cord-005453-4057qib7 2742 214 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 215 and and CC cord-005453-4057qib7 2742 216 holds hold VBZ cord-005453-4057qib7 2742 217 stock stock NN cord-005453-4057qib7 2742 218 and/ and/ CD cord-005453-4057qib7 2742 219 or or CC cord-005453-4057qib7 2742 220 stock stock NN cord-005453-4057qib7 2742 221 options option NNS cord-005453-4057qib7 2742 222 in in IN cord-005453-4057qib7 2742 223 Jazz Jazz NNP cord-005453-4057qib7 2742 224 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 2742 225 plc plc NNP cord-005453-4057qib7 2742 226 , , , cord-005453-4057qib7 2742 227 Zakaria Zakaria NNP cord-005453-4057qib7 2742 228 Medeghri Medeghri NNP cord-005453-4057qib7 2742 229 : : : cord-005453-4057qib7 2742 230 employee employee NN cord-005453-4057qib7 2742 231 of of IN cord-005453-4057qib7 2742 232 Jazz Jazz NNP cord-005453-4057qib7 2742 233 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2742 234 and and CC cord-005453-4057qib7 2742 235 holds hold VBZ cord-005453-4057qib7 2742 236 stock stock NN cord-005453-4057qib7 2742 237 and/or and/or CC cord-005453-4057qib7 2742 238 stock stock NN cord-005453-4057qib7 2742 239 options option NNS cord-005453-4057qib7 2742 240 in in IN cord-005453-4057qib7 2742 241 Jazz Jazz NNP cord-005453-4057qib7 2742 242 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 2742 243 plc plc NNP cord-005453-4057qib7 2742 244 P137 p137 CD cord-005453-4057qib7 2742 245 Incidence Incidence NNP cord-005453-4057qib7 2742 246 and and CC cord-005453-4057qib7 2742 247 predictors predictor NNS cord-005453-4057qib7 2742 248 of of IN cord-005453-4057qib7 2742 249 severe severe JJ cord-005453-4057qib7 2742 250 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 2742 251 in in IN cord-005453-4057qib7 2742 252 patients patient NNS cord-005453-4057qib7 2742 253 with with IN cord-005453-4057qib7 2742 254 severe severe JJ cord-005453-4057qib7 2742 255 aplastic aplastic JJ cord-005453-4057qib7 2742 256 anemia anemia NN cord-005453-4057qib7 2742 257 after after IN cord-005453-4057qib7 2742 258 haploidentical haploidentical JJ cord-005453-4057qib7 2742 259 hematopoietic hematopoietic JJ cord-005453-4057qib7 2742 260 stem stem NN cord-005453-4057qib7 2742 261 cell cell NN cord-005453-4057qib7 2742 262 transplantation transplantation NN cord-005453-4057qib7 2742 263 Zheng Zheng NNP cord-005453-4057qib7 2742 264 - - HYPH cord-005453-4057qib7 2742 265 Li Li NNP cord-005453-4057qib7 2742 266 Xu Xu NNP cord-005453-4057qib7 2742 267 1 1 CD cord-005453-4057qib7 2742 268 , , , cord-005453-4057qib7 2742 269 Lan Lan NNP cord-005453-4057qib7 2742 270 - - HYPH cord-005453-4057qib7 2742 271 Ping Ping NNP cord-005453-4057qib7 2742 272 Xu Xu NNP cord-005453-4057qib7 2742 273 1 1 CD cord-005453-4057qib7 2742 274 , , , cord-005453-4057qib7 2742 275 Yuan Yuan NNP cord-005453-4057qib7 2742 276 - - HYPH cord-005453-4057qib7 2742 277 Yuan Yuan NNP cord-005453-4057qib7 2742 278 Zhang Zhang NNP cord-005453-4057qib7 2742 279 1 1 CD cord-005453-4057qib7 2742 280 , , , cord-005453-4057qib7 2742 281 Yi Yi NNP cord-005453-4057qib7 2742 282 - - HYPH cord-005453-4057qib7 2742 283 Fei Fei NNP cord-005453-4057qib7 2742 284 Cheng Cheng NNP cord-005453-4057qib7 2742 285 1 1 CD cord-005453-4057qib7 2742 286 , , , cord-005453-4057qib7 2742 287 Xiao Xiao NNP cord-005453-4057qib7 2742 288 - - HYPH cord-005453-4057qib7 2742 289 Dong Dong NNP cord-005453-4057qib7 2742 290 Mo Mo NNP cord-005453-4057qib7 2742 291 1 1 CD cord-005453-4057qib7 2742 292 , , , cord-005453-4057qib7 2742 293 Feng Feng NNP cord-005453-4057qib7 2742 294 - - HYPH cord-005453-4057qib7 2742 295 Rong Rong NNP cord-005453-4057qib7 2742 296 Wang Wang NNP cord-005453-4057qib7 2742 297 1 1 CD cord-005453-4057qib7 2742 298 , , , cord-005453-4057qib7 2742 299 Yu Yu NNP cord-005453-4057qib7 2742 300 - - HYPH cord-005453-4057qib7 2742 301 Hong Hong NNP cord-005453-4057qib7 2742 302 Chen Chen NNP cord-005453-4057qib7 2742 303 1 1 CD cord-005453-4057qib7 2742 304 , , , cord-005453-4057qib7 2742 305 Wei Wei NNP cord-005453-4057qib7 2742 306 Han Han NNP cord-005453-4057qib7 2742 307 1 1 CD cord-005453-4057qib7 2742 308 , , , cord-005453-4057qib7 2742 309 Chen Chen NNP cord-005453-4057qib7 2742 310 - - HYPH cord-005453-4057qib7 2742 311 Hua Hua NNP cord-005453-4057qib7 2742 312 Yan Yan NNP cord-005453-4057qib7 2742 313 1 1 CD cord-005453-4057qib7 2742 314 , , , cord-005453-4057qib7 2743 1 Yu Yu NNP cord-005453-4057qib7 2743 2 - - HYPH cord-005453-4057qib7 2743 3 Qian Qian NNP cord-005453-4057qib7 2743 4 Sun Sun NNP cord-005453-4057qib7 2743 5 1 1 CD cord-005453-4057qib7 2743 6 , , , cord-005453-4057qib7 2743 7 Ting Ting NNP cord-005453-4057qib7 2743 8 - - HYPH cord-005453-4057qib7 2743 9 Ting Ting NNP cord-005453-4057qib7 2743 10 Han Han NNP cord-005453-4057qib7 2743 11 1 1 CD cord-005453-4057qib7 2743 12 , , , cord-005453-4057qib7 2743 13 Yu Yu NNP cord-005453-4057qib7 2743 14 Wang Wang NNP cord-005453-4057qib7 2743 15 1 1 CD cord-005453-4057qib7 2743 16 , , , cord-005453-4057qib7 2743 17 Xiao Xiao NNP cord-005453-4057qib7 2743 18 - - HYPH cord-005453-4057qib7 2743 19 Hui Hui NNP cord-005453-4057qib7 2743 20 Zhang Zhang NNP cord-005453-4057qib7 2743 21 1 1 CD cord-005453-4057qib7 2743 22 , , , cord-005453-4057qib7 2743 23 Xiao Xiao NNP cord-005453-4057qib7 2743 24 - - HYPH cord-005453-4057qib7 2743 25 Jun Jun NNP cord-005453-4057qib7 2743 26 Huang Huang NNP cord-005453-4057qib7 2743 27 1 1 CD cord-005453-4057qib7 2743 28 1 1 CD cord-005453-4057qib7 2743 29 Peking Peking NNP cord-005453-4057qib7 2743 30 University University NNP cord-005453-4057qib7 2743 31 Institute Institute NNP cord-005453-4057qib7 2743 32 of of IN cord-005453-4057qib7 2743 33 Hematology Hematology NNP cord-005453-4057qib7 2743 34 , , , cord-005453-4057qib7 2743 35 Peking Peking NNP cord-005453-4057qib7 2743 36 University University NNP cord-005453-4057qib7 2743 37 People People NNPS cord-005453-4057qib7 2743 38 's 's POS cord-005453-4057qib7 2743 39 Hospital Hospital NNP cord-005453-4057qib7 2743 40 , , , cord-005453-4057qib7 2743 41 Beijing Beijing NNP cord-005453-4057qib7 2743 42 , , , cord-005453-4057qib7 2744 1 China China NNP cord-005453-4057qib7 2744 2 Background Background NNP cord-005453-4057qib7 2744 3 : : : cord-005453-4057qib7 2745 1 Severe severe JJ cord-005453-4057qib7 2745 2 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 2745 3 after after IN cord-005453-4057qib7 2745 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 2745 5 stem stem NN cord-005453-4057qib7 2745 6 cell cell NN cord-005453-4057qib7 2745 7 transplantation transplantation NN cord-005453-4057qib7 2745 8 ( ( -LRB- cord-005453-4057qib7 2745 9 HSCT HSCT NNP cord-005453-4057qib7 2745 10 ) ) -RRB- cord-005453-4057qib7 2745 11 is be VBZ cord-005453-4057qib7 2745 12 a a DT cord-005453-4057qib7 2745 13 rare rare JJ cord-005453-4057qib7 2745 14 but but CC cord-005453-4057qib7 2745 15 fatal fatal JJ cord-005453-4057qib7 2745 16 complication complication NN cord-005453-4057qib7 2745 17 . . . cord-005453-4057qib7 2746 1 The the DT cord-005453-4057qib7 2746 2 aim aim NN cord-005453-4057qib7 2746 3 of of IN cord-005453-4057qib7 2746 4 this this DT cord-005453-4057qib7 2746 5 study study NN cord-005453-4057qib7 2746 6 was be VBD cord-005453-4057qib7 2746 7 to to TO cord-005453-4057qib7 2746 8 evaluate evaluate VB cord-005453-4057qib7 2746 9 the the DT cord-005453-4057qib7 2746 10 frequency frequency NN cord-005453-4057qib7 2746 11 of of IN cord-005453-4057qib7 2746 12 severe severe JJ cord-005453-4057qib7 2746 13 cardiac cardiac JJ cord-005453-4057qib7 2746 14 complications complication NNS cord-005453-4057qib7 2746 15 and and CC cord-005453-4057qib7 2746 16 to to TO cord-005453-4057qib7 2746 17 assess assess VB cord-005453-4057qib7 2746 18 the the DT cord-005453-4057qib7 2746 19 ability ability NN cord-005453-4057qib7 2746 20 of of IN cord-005453-4057qib7 2746 21 various various JJ cord-005453-4057qib7 2746 22 factors factor NNS cord-005453-4057qib7 2746 23 to to TO cord-005453-4057qib7 2746 24 predict predict VB cord-005453-4057qib7 2746 25 these these DT cord-005453-4057qib7 2746 26 complications complication NNS cord-005453-4057qib7 2746 27 in in IN cord-005453-4057qib7 2746 28 patients patient NNS cord-005453-4057qib7 2746 29 with with IN cord-005453-4057qib7 2746 30 aplastic aplastic JJ cord-005453-4057qib7 2746 31 anemia anemia NN cord-005453-4057qib7 2746 32 after after IN cord-005453-4057qib7 2746 33 haploidentical haploidentical JJ cord-005453-4057qib7 2746 34 transplantation transplantation NN cord-005453-4057qib7 2746 35 . . . cord-005453-4057qib7 2747 1 , , , cord-005453-4057qib7 2747 2 this this DT cord-005453-4057qib7 2747 3 is be VBZ cord-005453-4057qib7 2747 4 the the DT cord-005453-4057qib7 2747 5 first first JJ cord-005453-4057qib7 2747 6 study study NN cord-005453-4057qib7 2747 7 evaluating evaluate VBG cord-005453-4057qib7 2747 8 the the DT cord-005453-4057qib7 2747 9 values value NNS cord-005453-4057qib7 2747 10 of of IN cord-005453-4057qib7 2747 11 both both CC cord-005453-4057qib7 2747 12 clinical clinical JJ cord-005453-4057qib7 2747 13 and and CC cord-005453-4057qib7 2747 14 imaging imaging NN cord-005453-4057qib7 2747 15 factors factor NNS cord-005453-4057qib7 2747 16 in in IN cord-005453-4057qib7 2747 17 the the DT cord-005453-4057qib7 2747 18 prediction prediction NN cord-005453-4057qib7 2747 19 of of IN cord-005453-4057qib7 2747 20 severe severe JJ cord-005453-4057qib7 2747 21 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 2747 22 among among IN cord-005453-4057qib7 2747 23 SAA SAA NNP cord-005453-4057qib7 2747 24 patients patient NNS cord-005453-4057qib7 2747 25 after after IN cord-005453-4057qib7 2747 26 haploidentical haploidentical JJ cord-005453-4057qib7 2747 27 transplantation transplantation NN cord-005453-4057qib7 2747 28 . . . cord-005453-4057qib7 2748 1 Methods method NNS cord-005453-4057qib7 2748 2 : : : cord-005453-4057qib7 2748 3 A a DT cord-005453-4057qib7 2748 4 retrospective retrospective JJ cord-005453-4057qib7 2748 5 study study NN cord-005453-4057qib7 2748 6 was be VBD cord-005453-4057qib7 2748 7 conducted conduct VBN cord-005453-4057qib7 2748 8 in in IN cord-005453-4057qib7 2748 9 216 216 CD cord-005453-4057qib7 2748 10 consecutive consecutive JJ cord-005453-4057qib7 2748 11 aplastic aplastic JJ cord-005453-4057qib7 2748 12 anemia anemia NN cord-005453-4057qib7 2748 13 patients patient NNS cord-005453-4057qib7 2748 14 who who WP cord-005453-4057qib7 2748 15 received receive VBD cord-005453-4057qib7 2748 16 haploidentical haploidentical JJ cord-005453-4057qib7 2748 17 transplantation transplantation NN cord-005453-4057qib7 2748 18 from from IN cord-005453-4057qib7 2748 19 2006 2006 CD cord-005453-4057qib7 2748 20 to to IN cord-005453-4057qib7 2748 21 2017 2017 CD cord-005453-4057qib7 2748 22 . . . cord-005453-4057qib7 2749 1 All all DT cord-005453-4057qib7 2749 2 patients patient NNS cord-005453-4057qib7 2749 3 received receive VBD cord-005453-4057qib7 2749 4 a a DT cord-005453-4057qib7 2749 5 unified unified JJ cord-005453-4057qib7 2749 6 regimen regimen NN cord-005453-4057qib7 2749 7 including include VBG cord-005453-4057qib7 2749 8 busulfan busulfan NN cord-005453-4057qib7 2749 9 , , , cord-005453-4057qib7 2749 10 cyclophosphamide cyclophosphamide FW cord-005453-4057qib7 2749 11 ( ( -LRB- cord-005453-4057qib7 2749 12 CTX CTX NNP cord-005453-4057qib7 2749 13 ) ) -RRB- cord-005453-4057qib7 2749 14 and and CC cord-005453-4057qib7 2749 15 antithymocyte antithymocyte NNP cord-005453-4057qib7 2749 16 globulin globulin NN cord-005453-4057qib7 2749 17 at at IN cord-005453-4057qib7 2749 18 our -PRON- PRP$ cord-005453-4057qib7 2749 19 single single JJ cord-005453-4057qib7 2749 20 center center NN cord-005453-4057qib7 2749 21 . . . cord-005453-4057qib7 2750 1 Results result NNS cord-005453-4057qib7 2750 2 : : : cord-005453-4057qib7 2751 1 A a DT cord-005453-4057qib7 2751 2 total total NN cord-005453-4057qib7 2751 3 of of IN cord-005453-4057qib7 2751 4 12 12 CD cord-005453-4057qib7 2751 5 ( ( -LRB- cord-005453-4057qib7 2751 6 5.6 5.6 CD cord-005453-4057qib7 2751 7 % % NN cord-005453-4057qib7 2751 8 ) ) -RRB- cord-005453-4057qib7 2751 9 patients patient NNS cord-005453-4057qib7 2751 10 developed develop VBD cord-005453-4057qib7 2751 11 grade grade NN cord-005453-4057qib7 2751 12 III III NNP cord-005453-4057qib7 2751 13 or or CC cord-005453-4057qib7 2751 14 IV IV NNP cord-005453-4057qib7 2751 15 cardiac cardiac JJ cord-005453-4057qib7 2751 16 toxicity toxicity NN cord-005453-4057qib7 2751 17 . . . cord-005453-4057qib7 2752 1 Patients patient NNS cord-005453-4057qib7 2752 2 with with IN cord-005453-4057qib7 2752 3 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 2752 4 had have VBD cord-005453-4057qib7 2752 5 significantly significantly RB cord-005453-4057qib7 2752 6 poorer poor JJR cord-005453-4057qib7 2752 7 overall overall JJ cord-005453-4057qib7 2752 8 survival survival NN cord-005453-4057qib7 2752 9 ( ( -LRB- cord-005453-4057qib7 2752 10 OS OS NNP cord-005453-4057qib7 2752 11 ) ) -RRB- cord-005453-4057qib7 2752 12 than than IN cord-005453-4057qib7 2752 13 those those DT cord-005453-4057qib7 2752 14 without without IN cord-005453-4057qib7 2752 15 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 2752 16 ( ( -LRB- cord-005453-4057qib7 2752 17 12.5 12.5 CD cord-005453-4057qib7 2752 18 % % NN cord-005453-4057qib7 2752 19 vs. vs. CC cord-005453-4057qib7 2752 20 89.6 89.6 CD cord-005453-4057qib7 2752 21 % % NN cord-005453-4057qib7 2752 22 , , , cord-005453-4057qib7 2752 23 P p NN cord-005453-4057qib7 2752 24 < < XX cord-005453-4057qib7 2752 25 0.001 0.001 CD cord-005453-4057qib7 2752 26 ) ) -RRB- cord-005453-4057qib7 2752 27 . . . cord-005453-4057qib7 2753 1 Our -PRON- PRP$ cord-005453-4057qib7 2753 2 multivariable multivariable JJ cord-005453-4057qib7 2753 3 model model NN cord-005453-4057qib7 2753 4 identified identify VBD cord-005453-4057qib7 2753 5 four four CD cord-005453-4057qib7 2753 6 independent independent JJ cord-005453-4057qib7 2753 7 adverse adverse JJ cord-005453-4057qib7 2753 8 predictors predictor NNS cord-005453-4057qib7 2753 9 of of IN cord-005453-4057qib7 2753 10 severe severe JJ cord-005453-4057qib7 2753 11 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 2753 12 , , , cord-005453-4057qib7 2753 13 including include VBG cord-005453-4057qib7 2753 14 pre pre JJ cord-005453-4057qib7 2753 15 - - JJ cord-005453-4057qib7 2753 16 transplant transplant JJ cord-005453-4057qib7 2753 17 ECOG ECOG NNP cord-005453-4057qib7 2753 18 score score NN cord-005453-4057qib7 2753 19 ( ( -LRB- cord-005453-4057qib7 2753 20 ≥2 ≥2 NNP cord-005453-4057qib7 2753 21 ) ) -RRB- cord-005453-4057qib7 2753 22 , , , cord-005453-4057qib7 2753 23 abnormal abnormal JJ cord-005453-4057qib7 2753 24 ST ST NNP cord-005453-4057qib7 2753 25 - - HYPH cord-005453-4057qib7 2753 26 T T NNP cord-005453-4057qib7 2753 27 wave wave NN cord-005453-4057qib7 2753 28 on on IN cord-005453-4057qib7 2753 29 12-lead 12-lead JJ cord-005453-4057qib7 2753 30 electrocardiogram electrocardiogram NN cord-005453-4057qib7 2753 31 ( ( -LRB- cord-005453-4057qib7 2753 32 ECG ECG NNP cord-005453-4057qib7 2753 33 ) ) -RRB- cord-005453-4057qib7 2753 34 , , , cord-005453-4057qib7 2753 35 hyperlipemia hyperlipemia NNP cord-005453-4057qib7 2753 36 and and CC cord-005453-4057qib7 2753 37 recalculated recalculate VBD cord-005453-4057qib7 2753 38 CTX CTX NNP cord-005453-4057qib7 2753 39 dose dose NN cord-005453-4057qib7 2753 40 ( ( -LRB- cord-005453-4057qib7 2753 41 ≥1.8 ≥1.8 NNP cord-005453-4057qib7 2753 42 g g NNP cord-005453-4057qib7 2753 43 / / SYM cord-005453-4057qib7 2753 44 m2 m2 NNP cord-005453-4057qib7 2753 45 / / SYM cord-005453-4057qib7 2753 46 d d NN cord-005453-4057qib7 2753 47 ) ) -RRB- cord-005453-4057qib7 2753 48 . . . cord-005453-4057qib7 2754 1 A a DT cord-005453-4057qib7 2754 2 predictive predictive JJ cord-005453-4057qib7 2754 3 risk risk NN cord-005453-4057qib7 2754 4 model model NN cord-005453-4057qib7 2754 5 was be VBD cord-005453-4057qib7 2754 6 refined refine VBN cord-005453-4057qib7 2754 7 as as IN cord-005453-4057qib7 2754 8 low low JJ cord-005453-4057qib7 2754 9 risk risk NN cord-005453-4057qib7 2754 10 ( ( -LRB- cord-005453-4057qib7 2754 11 0 0 CD cord-005453-4057qib7 2754 12 - - SYM cord-005453-4057qib7 2754 13 1 1 CD cord-005453-4057qib7 2754 14 factor factor NN cord-005453-4057qib7 2754 15 ) ) -RRB- cord-005453-4057qib7 2754 16 , , , cord-005453-4057qib7 2754 17 intermediate intermediate JJ cord-005453-4057qib7 2754 18 risk risk NN cord-005453-4057qib7 2754 19 ( ( -LRB- cord-005453-4057qib7 2754 20 2 2 CD cord-005453-4057qib7 2754 21 factors factor NNS cord-005453-4057qib7 2754 22 ) ) -RRB- cord-005453-4057qib7 2754 23 and and CC cord-005453-4057qib7 2754 24 high high JJ cord-005453-4057qib7 2754 25 risk risk NN cord-005453-4057qib7 2754 26 ( ( -LRB- cord-005453-4057qib7 2754 27 3 3 CD cord-005453-4057qib7 2754 28 - - SYM cord-005453-4057qib7 2754 29 4 4 CD cord-005453-4057qib7 2754 30 factors factor NNS cord-005453-4057qib7 2754 31 ) ) -RRB- cord-005453-4057qib7 2754 32 . . . cord-005453-4057qib7 2755 1 The the DT cord-005453-4057qib7 2755 2 respective respective JJ cord-005453-4057qib7 2755 3 incidences incidence NNS cord-005453-4057qib7 2755 4 of of IN cord-005453-4057qib7 2755 5 severe severe JJ cord-005453-4057qib7 2755 6 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 2755 7 were be VBD cord-005453-4057qib7 2755 8 50.0 50.0 CD cord-005453-4057qib7 2755 9 % % NN cord-005453-4057qib7 2755 10 , , , cord-005453-4057qib7 2755 11 6.0 6.0 CD cord-005453-4057qib7 2755 12 % % NN cord-005453-4057qib7 2755 13 , , , cord-005453-4057qib7 2755 14 and and CC cord-005453-4057qib7 2755 15 1.3 1.3 CD cord-005453-4057qib7 2755 16 % % NN cord-005453-4057qib7 2755 17 in in IN cord-005453-4057qib7 2755 18 the the DT cord-005453-4057qib7 2755 19 high- high- JJ cord-005453-4057qib7 2755 20 , , , cord-005453-4057qib7 2755 21 intermediate intermediate JJ cord-005453-4057qib7 2755 22 - - HYPH cord-005453-4057qib7 2755 23 and and CC cord-005453-4057qib7 2755 24 low low JJ cord-005453-4057qib7 2755 25 - - HYPH cord-005453-4057qib7 2755 26 risk risk NN cord-005453-4057qib7 2755 27 groups group NNS cord-005453-4057qib7 2755 28 ( ( -LRB- cord-005453-4057qib7 2755 29 P p NN cord-005453-4057qib7 2755 30 < < XX cord-005453-4057qib7 2755 31 0.001 0.001 CD cord-005453-4057qib7 2755 32 ) ) -RRB- cord-005453-4057qib7 2755 33 . . . cord-005453-4057qib7 2756 1 The the DT cord-005453-4057qib7 2756 2 corresponding corresponding JJ cord-005453-4057qib7 2756 3 OS os NN cord-005453-4057qib7 2756 4 rates rate NNS cord-005453-4057qib7 2756 5 were be VBD cord-005453-4057qib7 2756 6 49.0 49.0 CD cord-005453-4057qib7 2756 7 % % NN cord-005453-4057qib7 2756 8 , , , cord-005453-4057qib7 2756 9 80.4 80.4 CD cord-005453-4057qib7 2756 10 % % NN cord-005453-4057qib7 2756 11 , , , cord-005453-4057qib7 2756 12 and and CC cord-005453-4057qib7 2756 13 90.3 90.3 CD cord-005453-4057qib7 2756 14 % % NN cord-005453-4057qib7 2756 15 in in IN cord-005453-4057qib7 2756 16 the the DT cord-005453-4057qib7 2756 17 three three CD cord-005453-4057qib7 2756 18 groups group NNS cord-005453-4057qib7 2756 19 ( ( -LRB- cord-005453-4057qib7 2756 20 P p NN cord-005453-4057qib7 2756 21 < < XX cord-005453-4057qib7 2756 22 0.001 0.001 CD cord-005453-4057qib7 2756 23 ) ) -RRB- cord-005453-4057qib7 2756 24 at at IN cord-005453-4057qib7 2756 25 the the DT cord-005453-4057qib7 2756 26 last last JJ cord-005453-4057qib7 2756 27 follow follow NN cord-005453-4057qib7 2756 28 - - HYPH cord-005453-4057qib7 2756 29 up up NN cord-005453-4057qib7 2756 30 . . . cord-005453-4057qib7 2757 1 Conclusions conclusion NNS cord-005453-4057qib7 2757 2 : : : cord-005453-4057qib7 2758 1 Patients patient NNS cord-005453-4057qib7 2758 2 with with IN cord-005453-4057qib7 2758 3 high high JJ cord-005453-4057qib7 2758 4 risk risk NN cord-005453-4057qib7 2758 5 scores score NNS cord-005453-4057qib7 2758 6 had have VBD cord-005453-4057qib7 2758 7 the the DT cord-005453-4057qib7 2758 8 poorest poor JJS cord-005453-4057qib7 2758 9 outcomes outcome NNS cord-005453-4057qib7 2758 10 and and CC cord-005453-4057qib7 2758 11 should should MD cord-005453-4057qib7 2758 12 be be VB cord-005453-4057qib7 2758 13 monitored monitor VBN cord-005453-4057qib7 2758 14 closely closely RB cord-005453-4057qib7 2758 15 . . . cord-005453-4057qib7 2759 1 A a DT cord-005453-4057qib7 2759 2 reduced reduce VBN cord-005453-4057qib7 2759 3 intensity intensity NN cord-005453-4057qib7 2759 4 conditioning conditioning NN cord-005453-4057qib7 2759 5 might may MD cord-005453-4057qib7 2759 6 be be VB cord-005453-4057qib7 2759 7 recommended recommend VBN cord-005453-4057qib7 2759 8 for for IN cord-005453-4057qib7 2759 9 these these DT cord-005453-4057qib7 2759 10 patients patient NNS cord-005453-4057qib7 2759 11 . . . cord-005453-4057qib7 2760 1 Disclosure disclosure NN cord-005453-4057qib7 2760 2 : : : cord-005453-4057qib7 2760 3 There there EX cord-005453-4057qib7 2760 4 are be VBP cord-005453-4057qib7 2760 5 no no DT cord-005453-4057qib7 2760 6 conflicts conflict NNS cord-005453-4057qib7 2760 7 of of IN cord-005453-4057qib7 2760 8 interest interest NN cord-005453-4057qib7 2760 9 to to TO cord-005453-4057qib7 2760 10 declare declare VB cord-005453-4057qib7 2760 11 . . . cord-005453-4057qib7 2761 1 Background background NN cord-005453-4057qib7 2761 2 : : : cord-005453-4057qib7 2762 1 Allogeneic allogeneic IN cord-005453-4057qib7 2762 2 stem stem NN cord-005453-4057qib7 2762 3 - - HYPH cord-005453-4057qib7 2762 4 cell cell NN cord-005453-4057qib7 2762 5 transplantation transplantation NN cord-005453-4057qib7 2762 6 ( ( -LRB- cord-005453-4057qib7 2762 7 allo allo FW cord-005453-4057qib7 2762 8 - - HYPH cord-005453-4057qib7 2762 9 SCT SCT NNP cord-005453-4057qib7 2762 10 ) ) -RRB- cord-005453-4057qib7 2762 11 is be VBZ cord-005453-4057qib7 2762 12 associated associate VBN cord-005453-4057qib7 2762 13 with with IN cord-005453-4057qib7 2762 14 significant significant JJ cord-005453-4057qib7 2762 15 transplant transplant NN cord-005453-4057qib7 2762 16 - - HYPH cord-005453-4057qib7 2762 17 related relate VBN cord-005453-4057qib7 2762 18 mortality mortality NN cord-005453-4057qib7 2762 19 ( ( -LRB- cord-005453-4057qib7 2762 20 TRM TRM NNP cord-005453-4057qib7 2762 21 ) ) -RRB- cord-005453-4057qib7 2762 22 . . . cord-005453-4057qib7 2763 1 Acute acute JJ cord-005453-4057qib7 2763 2 renal renal JJ cord-005453-4057qib7 2763 3 failure failure NN cord-005453-4057qib7 2763 4 ( ( -LRB- cord-005453-4057qib7 2763 5 ARF ARF NNP cord-005453-4057qib7 2763 6 ) ) -RRB- cord-005453-4057qib7 2763 7 is be VBZ cord-005453-4057qib7 2763 8 a a DT cord-005453-4057qib7 2763 9 frequent frequent JJ cord-005453-4057qib7 2763 10 complication complication NN cord-005453-4057qib7 2763 11 and and CC cord-005453-4057qib7 2763 12 usually usually RB cord-005453-4057qib7 2763 13 presents present VBZ cord-005453-4057qib7 2763 14 early early RB cord-005453-4057qib7 2763 15 after after IN cord-005453-4057qib7 2763 16 the the DT cord-005453-4057qib7 2763 17 procedure procedure NN cord-005453-4057qib7 2763 18 , , , cord-005453-4057qib7 2763 19 compromising compromise VBG cord-005453-4057qib7 2763 20 its -PRON- PRP$ cord-005453-4057qib7 2763 21 feasibility feasibility NN cord-005453-4057qib7 2763 22 . . . cord-005453-4057qib7 2764 1 The the DT cord-005453-4057qib7 2764 2 aim aim NN cord-005453-4057qib7 2764 3 of of IN cord-005453-4057qib7 2764 4 this this DT cord-005453-4057qib7 2764 5 study study NN cord-005453-4057qib7 2764 6 is be VBZ cord-005453-4057qib7 2764 7 to to TO cord-005453-4057qib7 2764 8 analyse analyse VB cord-005453-4057qib7 2764 9 the the DT cord-005453-4057qib7 2764 10 incidence incidence NN cord-005453-4057qib7 2764 11 of of IN cord-005453-4057qib7 2764 12 ARF ARF NNP cord-005453-4057qib7 2764 13 , , , cord-005453-4057qib7 2764 14 its -PRON- PRP$ cord-005453-4057qib7 2764 15 risk risk NN cord-005453-4057qib7 2764 16 factors factor NNS cord-005453-4057qib7 2764 17 and and CC cord-005453-4057qib7 2764 18 its -PRON- PRP$ cord-005453-4057qib7 2764 19 potential potential JJ cord-005453-4057qib7 2764 20 impact impact NN cord-005453-4057qib7 2764 21 on on IN cord-005453-4057qib7 2764 22 TRM TRM NNP cord-005453-4057qib7 2764 23 after after IN cord-005453-4057qib7 2764 24 allo allo NN cord-005453-4057qib7 2764 25 - - HYPH cord-005453-4057qib7 2764 26 SCT SCT NNP cord-005453-4057qib7 2764 27 . . . cord-005453-4057qib7 2765 1 Methods method NNS cord-005453-4057qib7 2765 2 : : : cord-005453-4057qib7 2765 3 422 422 CD cord-005453-4057qib7 2765 4 patients patient NNS cord-005453-4057qib7 2765 5 were be VBD cord-005453-4057qib7 2765 6 included include VBN cord-005453-4057qib7 2765 7 ( ( -LRB- cord-005453-4057qib7 2765 8 244 244 CD cord-005453-4057qib7 2765 9 males male NNS cord-005453-4057qib7 2765 10 [ [ -LRB- cord-005453-4057qib7 2765 11 58 58 CD cord-005453-4057qib7 2765 12 % % NN cord-005453-4057qib7 2765 13 ] ] -RRB- cord-005453-4057qib7 2766 1 ; ; : cord-005453-4057qib7 2766 2 median median NN cord-005453-4057qib7 2766 3 age age NN cord-005453-4057qib7 2766 4 43 43 CD cord-005453-4057qib7 2766 5 years year NNS cord-005453-4057qib7 2766 6 , , , cord-005453-4057qib7 2766 7 range range VBP cord-005453-4057qib7 2766 8 16 16 CD cord-005453-4057qib7 2766 9 - - SYM cord-005453-4057qib7 2766 10 67 67 CD cord-005453-4057qib7 2766 11 ) ) -RRB- cord-005453-4057qib7 2766 12 treated treat VBN cord-005453-4057qib7 2766 13 with with IN cord-005453-4057qib7 2766 14 Allo Allo NNP cord-005453-4057qib7 2766 15 - - HYPH cord-005453-4057qib7 2766 16 SCT SCT NNP cord-005453-4057qib7 2766 17 consecutively consecutively RB cord-005453-4057qib7 2766 18 between between IN cord-005453-4057qib7 2766 19 January January NNP cord-005453-4057qib7 2766 20 2001 2001 CD cord-005453-4057qib7 2766 21 and and CC cord-005453-4057qib7 2766 22 April April NNP cord-005453-4057qib7 2766 23 2012 2012 CD cord-005453-4057qib7 2766 24 in in IN cord-005453-4057qib7 2766 25 a a DT cord-005453-4057qib7 2766 26 single single JJ cord-005453-4057qib7 2766 27 institution institution NN cord-005453-4057qib7 2766 28 . . . cord-005453-4057qib7 2767 1 Patient patient JJ cord-005453-4057qib7 2767 2 characteristics characteristic NNS cord-005453-4057qib7 2767 3 are be VBP cord-005453-4057qib7 2767 4 detailed detail VBN cord-005453-4057qib7 2767 5 in in IN cord-005453-4057qib7 2767 6 table table NN cord-005453-4057qib7 2767 7 1 1 CD cord-005453-4057qib7 2767 8 . . . cord-005453-4057qib7 2768 1 Median median JJ cord-005453-4057qib7 2768 2 follow follow NN cord-005453-4057qib7 2768 3 - - HYPH cord-005453-4057qib7 2768 4 up up NN cord-005453-4057qib7 2768 5 was be VBD cord-005453-4057qib7 2768 6 1.8 1.8 CD cord-005453-4057qib7 2768 7 years year NNS cord-005453-4057qib7 2768 8 ( ( -LRB- cord-005453-4057qib7 2768 9 range range NN cord-005453-4057qib7 2768 10 , , , cord-005453-4057qib7 2768 11 1.0 1.0 CD cord-005453-4057qib7 2768 12 - - SYM cord-005453-4057qib7 2768 13 2.7 2.7 CD cord-005453-4057qib7 2768 14 ) ) -RRB- cord-005453-4057qib7 2768 15 . . . cord-005453-4057qib7 2769 1 Renal renal JJ cord-005453-4057qib7 2769 2 function function NN cord-005453-4057qib7 2769 3 was be VBD cord-005453-4057qib7 2769 4 evaluated evaluate VBN cord-005453-4057qib7 2769 5 using use VBG cord-005453-4057qib7 2769 6 creatinine creatinine NN cord-005453-4057qib7 2769 7 and and CC cord-005453-4057qib7 2769 8 data datum NNS cord-005453-4057qib7 2769 9 was be VBD cord-005453-4057qib7 2769 10 collected collect VBN cord-005453-4057qib7 2769 11 pre pre JJ cord-005453-4057qib7 2769 12 - - NN cord-005453-4057qib7 2769 13 transplant transplant JJ cord-005453-4057qib7 2769 14 ( ( -LRB- cord-005453-4057qib7 2769 15 baseline baseline NN cord-005453-4057qib7 2769 16 ) ) -RRB- cord-005453-4057qib7 2769 17 and and CC cord-005453-4057qib7 2769 18 at at IN cord-005453-4057qib7 2769 19 the the DT cord-005453-4057qib7 2769 20 point point NN cord-005453-4057qib7 2769 21 when when WRB cord-005453-4057qib7 2769 22 ARF ARF NNP cord-005453-4057qib7 2769 23 was be VBD cord-005453-4057qib7 2769 24 developed develop VBN cord-005453-4057qib7 2769 25 after after IN cord-005453-4057qib7 2769 26 allo allo NN cord-005453-4057qib7 2769 27 - - HYPH cord-005453-4057qib7 2769 28 SCT SCT NNP cord-005453-4057qib7 2769 29 . . . cord-005453-4057qib7 2770 1 ARF ARF NNP cord-005453-4057qib7 2770 2 was be VBD cord-005453-4057qib7 2770 3 evaluated evaluate VBN cord-005453-4057qib7 2770 4 using use VBG cord-005453-4057qib7 2770 5 AKIN akin NN cord-005453-4057qib7 2770 6 criteria criterion NNS cord-005453-4057qib7 2770 7 , , , cord-005453-4057qib7 2770 8 being be VBG cord-005453-4057qib7 2770 9 AKIN-1 akin-1 WP cord-005453-4057qib7 2770 10 an an DT cord-005453-4057qib7 2770 11 increase increase NN cord-005453-4057qib7 2770 12 1.5-to 1.5-to CD cord-005453-4057qib7 2770 13 1.9-fold 1.9-fold CD cord-005453-4057qib7 2770 14 from from IN cord-005453-4057qib7 2770 15 baseline baseline NN cord-005453-4057qib7 2770 16 , , , cord-005453-4057qib7 2770 17 AKIN-2 AKIN-2 NNP cord-005453-4057qib7 2770 18 an an DT cord-005453-4057qib7 2770 19 increase increase NN cord-005453-4057qib7 2771 1 2.0-to 2.0-to CD cord-005453-4057qib7 2771 2 2.0-fold 2.0-fold CD cord-005453-4057qib7 2771 3 and and CC cord-005453-4057qib7 2771 4 AKIN-3 AKIN-3 NNP cord-005453-4057qib7 2771 5 an an DT cord-005453-4057qib7 2771 6 increase increase NN cord-005453-4057qib7 2771 7 ≥3-fold ≥3-fold NN cord-005453-4057qib7 2771 8 . . . cord-005453-4057qib7 2772 1 Chronic chronic JJ cord-005453-4057qib7 2772 2 renal renal JJ cord-005453-4057qib7 2772 3 disease disease NN cord-005453-4057qib7 2772 4 was be VBD cord-005453-4057qib7 2772 5 evaluated evaluate VBN cord-005453-4057qib7 2772 6 one one CD cord-005453-4057qib7 2772 7 year year NN cord-005453-4057qib7 2772 8 after after IN cord-005453-4057qib7 2772 9 the the DT cord-005453-4057qib7 2772 10 date date NN cord-005453-4057qib7 2772 11 of of IN cord-005453-4057qib7 2772 12 ARF ARF NNP cord-005453-4057qib7 2772 13 using use VBG cord-005453-4057qib7 2772 14 KDIGO KDIGO NNP cord-005453-4057qib7 2772 15 criteria criterion NNS cord-005453-4057qib7 2772 16 . . . cord-005453-4057qib7 2773 1 Results result NNS cord-005453-4057qib7 2773 2 : : : cord-005453-4057qib7 2774 1 Cumulative cumulative JJ cord-005453-4057qib7 2774 2 incidence incidence NN cord-005453-4057qib7 2774 3 of of IN cord-005453-4057qib7 2774 4 ARF arf NN cord-005453-4057qib7 2774 5 at at IN cord-005453-4057qib7 2774 6 1 1 CD cord-005453-4057qib7 2774 7 year year NN cord-005453-4057qib7 2774 8 was be VBD cord-005453-4057qib7 2774 9 63 63 CD cord-005453-4057qib7 2774 10 % % NN cord-005453-4057qib7 2774 11 ( ( -LRB- cord-005453-4057qib7 2774 12 AKIN-1 AKIN-1 NNP cord-005453-4057qib7 2774 13 , , , cord-005453-4057qib7 2774 14 25 25 CD cord-005453-4057qib7 2774 15 % % NN cord-005453-4057qib7 2774 16 ; ; : cord-005453-4057qib7 2774 17 AKIN-2 AKIN-2 NNP cord-005453-4057qib7 2774 18 , , , cord-005453-4057qib7 2774 19 27 27 CD cord-005453-4057qib7 2774 20 % % NN cord-005453-4057qib7 2774 21 ; ; : cord-005453-4057qib7 2774 22 AKIN-3 AKIN-3 NNP cord-005453-4057qib7 2774 23 , , , cord-005453-4057qib7 2774 24 15 15 CD cord-005453-4057qib7 2774 25 % % NN cord-005453-4057qib7 2774 26 ) ) -RRB- cord-005453-4057qib7 2774 27 . . . cord-005453-4057qib7 2775 1 In in IN cord-005453-4057qib7 2775 2 the the DT cord-005453-4057qib7 2775 3 multivariate multivariate JJ cord-005453-4057qib7 2775 4 analysis analysis NN cord-005453-4057qib7 2775 5 , , , cord-005453-4057qib7 2775 6 ARF ARF NNP cord-005453-4057qib7 2775 7 ( ( -LRB- cord-005453-4057qib7 2775 8 AKIN-1/2 AKIN-1/2 NNP cord-005453-4057qib7 2775 9 ) ) -RRB- cord-005453-4057qib7 2775 10 was be VBD cord-005453-4057qib7 2775 11 associated associate VBN cord-005453-4057qib7 2775 12 with with IN cord-005453-4057qib7 2775 13 : : : cord-005453-4057qib7 2775 14 non non JJ cord-005453-4057qib7 2775 15 - - JJ cord-005453-4057qib7 2775 16 use use NN cord-005453-4057qib7 2775 17 of of IN cord-005453-4057qib7 2775 18 antithymocyte antithymocyte NNP cord-005453-4057qib7 2775 19 globulin globulin NN cord-005453-4057qib7 2775 20 in in IN cord-005453-4057qib7 2775 21 conditioning conditioning NN cord-005453-4057qib7 2775 22 chemotherapy chemotherapy NN cord-005453-4057qib7 2775 23 , , , cord-005453-4057qib7 2775 24 p=0.02 p=0.02 NNP cord-005453-4057qib7 2775 25 ( ( -LRB- cord-005453-4057qib7 2775 26 HR HR NNP cord-005453-4057qib7 2775 27 2.3 2.3 CD cord-005453-4057qib7 2775 28 , , , cord-005453-4057qib7 2775 29 0.2 0.2 CD cord-005453-4057qib7 2775 30 to to TO cord-005453-4057qib7 2775 31 0.9 0.9 CD cord-005453-4057qib7 2775 32 ) ) -RRB- cord-005453-4057qib7 2775 33 and and CC cord-005453-4057qib7 2775 34 development development NN cord-005453-4057qib7 2775 35 of of IN cord-005453-4057qib7 2775 36 severe severe JJ cord-005453-4057qib7 2775 37 aGvHD agvhd NN cord-005453-4057qib7 2775 38 , , , cord-005453-4057qib7 2775 39 p=0.04 p=0.04 NNP cord-005453-4057qib7 2775 40 ( ( -LRB- cord-005453-4057qib7 2775 41 HR= HR= NNP cord-005453-4057qib7 2775 42 1.5 1.5 CD cord-005453-4057qib7 2775 43 , , , cord-005453-4057qib7 2775 44 1 1 CD cord-005453-4057qib7 2775 45 to to IN cord-005453-4057qib7 2775 46 2.3 2.3 CD cord-005453-4057qib7 2775 47 ) ) -RRB- cord-005453-4057qib7 2775 48 . . . cord-005453-4057qib7 2776 1 In in IN cord-005453-4057qib7 2776 2 patients patient NNS cord-005453-4057qib7 2776 3 with with IN cord-005453-4057qib7 2776 4 ARF ARF NNP cord-005453-4057qib7 2776 5 AKIN-3 AKIN-3 NNP cord-005453-4057qib7 2776 6 , , , cord-005453-4057qib7 2776 7 the the DT cord-005453-4057qib7 2776 8 most most RBS cord-005453-4057qib7 2776 9 important important JJ cord-005453-4057qib7 2776 10 variables variable NNS cord-005453-4057qib7 2776 11 in in IN cord-005453-4057qib7 2776 12 the the DT cord-005453-4057qib7 2776 13 multivariate multivariate JJ cord-005453-4057qib7 2776 14 analysis analysis NN cord-005453-4057qib7 2776 15 were be VBD cord-005453-4057qib7 2776 16 : : : cord-005453-4057qib7 2776 17 use use NN cord-005453-4057qib7 2776 18 of of IN cord-005453-4057qib7 2776 19 methotrexate methotrexate NNP cord-005453-4057qib7 2776 20 ( ( -LRB- cord-005453-4057qib7 2776 21 MTX MTX NNP cord-005453-4057qib7 2776 22 ) ) -RRB- cord-005453-4057qib7 2776 23 plus plus CC cord-005453-4057qib7 2776 24 cyclosporine cyclosporine NN cord-005453-4057qib7 2776 25 vs vs IN cord-005453-4057qib7 2776 26 mycophenolate mycophenolate NNP cord-005453-4057qib7 2776 27 mofetil mofetil NNP cord-005453-4057qib7 2776 28 plus plus CC cord-005453-4057qib7 2776 29 cyclosporine cyclosporine NNP cord-005453-4057qib7 2776 30 as as IN cord-005453-4057qib7 2776 31 GvHD GvHD NNP cord-005453-4057qib7 2776 32 prophylaxis prophylaxis NN cord-005453-4057qib7 2776 33 , , , cord-005453-4057qib7 2776 34 p=0.009 p=0.009 NN cord-005453-4057qib7 2777 1 ( ( -LRB- cord-005453-4057qib7 2777 2 HR=1.9 HR=1.9 NNP cord-005453-4057qib7 2777 3 , , , cord-005453-4057qib7 2777 4 1.2 1.2 CD cord-005453-4057qib7 2777 5 to to IN cord-005453-4057qib7 2777 6 3.1 3.1 CD cord-005453-4057qib7 2777 7 ) ) -RRB- cord-005453-4057qib7 2777 8 ; ; : cord-005453-4057qib7 2777 9 myeloablative myeloablative NNP cord-005453-4057qib7 2777 10 conditioning conditioning NN cord-005453-4057qib7 2777 11 vs vs IN cord-005453-4057qib7 2777 12 reduced reduce VBN cord-005453-4057qib7 2777 13 intensity intensity NN cord-005453-4057qib7 2777 14 , , , cord-005453-4057qib7 2777 15 p=0.03 p=0.03 NN cord-005453-4057qib7 2777 16 ( ( -LRB- cord-005453-4057qib7 2777 17 HR=1.7 hr=1.7 NN cord-005453-4057qib7 2777 18 , , , cord-005453-4057qib7 2777 19 1 1 CD cord-005453-4057qib7 2777 20 to to IN cord-005453-4057qib7 2777 21 2.8 2.8 CD cord-005453-4057qib7 2777 22 ) ) -RRB- cord-005453-4057qib7 2777 23 and and CC cord-005453-4057qib7 2777 24 use use NN cord-005453-4057qib7 2777 25 of of IN cord-005453-4057qib7 2777 26 total total JJ cord-005453-4057qib7 2777 27 irradiation irradiation NN cord-005453-4057qib7 2777 28 therapy therapy NN cord-005453-4057qib7 2777 29 in in IN cord-005453-4057qib7 2777 30 conditioning conditioning NN cord-005453-4057qib7 2777 31 , , , cord-005453-4057qib7 2777 32 p=0.02 p=0.02 JJ cord-005453-4057qib7 2777 33 ( ( -LRB- cord-005453-4057qib7 2777 34 HR=1.7 hr=1.7 NN cord-005453-4057qib7 2777 35 , , , cord-005453-4057qib7 2777 36 1.1 1.1 CD cord-005453-4057qib7 2777 37 to to IN cord-005453-4057qib7 2777 38 2.8 2.8 CD cord-005453-4057qib7 2777 39 ) ) -RRB- cord-005453-4057qib7 2777 40 . . . cord-005453-4057qib7 2778 1 TRM TRM NNP cord-005453-4057qib7 2778 2 at at IN cord-005453-4057qib7 2778 3 1 1 CD cord-005453-4057qib7 2778 4 year year NN cord-005453-4057qib7 2778 5 increased increase VBD cord-005453-4057qib7 2778 6 significantly significantly RB cord-005453-4057qib7 2778 7 according accord VBG cord-005453-4057qib7 2778 8 to to IN cord-005453-4057qib7 2778 9 AKIN akin NN cord-005453-4057qib7 2778 10 : : : cord-005453-4057qib7 2779 1 AKIN-1 AKIN-1 NNP cord-005453-4057qib7 2779 2 , , , cord-005453-4057qib7 2779 3 25 25 CD cord-005453-4057qib7 2779 4 % % NN cord-005453-4057qib7 2779 5 ; ; : cord-005453-4057qib7 2779 6 AKIN akin NN cord-005453-4057qib7 2779 7 2 2 CD cord-005453-4057qib7 2779 8 , , , cord-005453-4057qib7 2779 9 35 35 CD cord-005453-4057qib7 2779 10 % % NN cord-005453-4057qib7 2779 11 ; ; : cord-005453-4057qib7 2779 12 AKIN AKIN NNP cord-005453-4057qib7 2779 13 3 3 CD cord-005453-4057qib7 2779 14 , , , cord-005453-4057qib7 2779 15 51 51 CD cord-005453-4057qib7 2779 16 % % NN cord-005453-4057qib7 2779 17 ; ; : cord-005453-4057qib7 2779 18 p=0,003 p=0,003 NN cord-005453-4057qib7 2779 19 ; ; : cord-005453-4057qib7 2779 20 HR=11.2 hr=11.2 ADD cord-005453-4057qib7 2779 21 . . . cord-005453-4057qib7 2780 1 Overall overall JJ cord-005453-4057qib7 2780 2 survival survival NN cord-005453-4057qib7 2780 3 at at IN cord-005453-4057qib7 2780 4 3 3 CD cord-005453-4057qib7 2780 5 years year NNS cord-005453-4057qib7 2780 6 according accord VBG cord-005453-4057qib7 2780 7 to to IN cord-005453-4057qib7 2780 8 AKIN AKIN NNP cord-005453-4057qib7 2780 9 was be VBD cord-005453-4057qib7 2780 10 : : : cord-005453-4057qib7 2780 11 AKIN akin NN cord-005453-4057qib7 2780 12 1 1 CD cord-005453-4057qib7 2780 13 , , , cord-005453-4057qib7 2780 14 52 52 CD cord-005453-4057qib7 2780 15 % % NN cord-005453-4057qib7 2780 16 , , , cord-005453-4057qib7 2780 17 AKIN akin NN cord-005453-4057qib7 2780 18 2 2 CD cord-005453-4057qib7 2780 19 , , , cord-005453-4057qib7 2780 20 45 45 CD cord-005453-4057qib7 2780 21 % % NN cord-005453-4057qib7 2780 22 and and CC cord-005453-4057qib7 2780 23 AKIN akin NN cord-005453-4057qib7 2780 24 3 3 CD cord-005453-4057qib7 2780 25 , , , cord-005453-4057qib7 2780 26 29 29 CD cord-005453-4057qib7 2780 27 % % NN cord-005453-4057qib7 2780 28 ; ; : cord-005453-4057qib7 2780 29 p=0,004 p=0,004 NNP cord-005453-4057qib7 2780 30 ( ( -LRB- cord-005453-4057qib7 2780 31 figure figure NN cord-005453-4057qib7 2780 32 1 1 CD cord-005453-4057qib7 2780 33 ) ) -RRB- cord-005453-4057qib7 2780 34 . . . cord-005453-4057qib7 2781 1 The the DT cord-005453-4057qib7 2781 2 incidence incidence NN cord-005453-4057qib7 2781 3 of of IN cord-005453-4057qib7 2781 4 chronic chronic JJ cord-005453-4057qib7 2781 5 renal renal JJ cord-005453-4057qib7 2781 6 disease disease NN cord-005453-4057qib7 2781 7 at at IN cord-005453-4057qib7 2781 8 1 1 CD cord-005453-4057qib7 2781 9 year year NN cord-005453-4057qib7 2781 10 after after IN cord-005453-4057qib7 2781 11 allo allo NNP cord-005453-4057qib7 2781 12 - - HYPH cord-005453-4057qib7 2781 13 SCT SCT NNP cord-005453-4057qib7 2781 14 according accord VBG cord-005453-4057qib7 2781 15 to to IN cord-005453-4057qib7 2781 16 ARF ARF NNP cord-005453-4057qib7 2781 17 was be VBD cord-005453-4057qib7 2781 18 : : : cord-005453-4057qib7 2781 19 no no DT cord-005453-4057qib7 2781 20 ARF arf NN cord-005453-4057qib7 2781 21 ( ( -LRB- cord-005453-4057qib7 2781 22 8 8 CD cord-005453-4057qib7 2781 23 % % NN cord-005453-4057qib7 2781 24 ) ) -RRB- cord-005453-4057qib7 2781 25 , , , cord-005453-4057qib7 2781 26 AKIN-1 AKIN-1 NNP cord-005453-4057qib7 2781 27 ( ( -LRB- cord-005453-4057qib7 2781 28 11 11 CD cord-005453-4057qib7 2781 29 % % NN cord-005453-4057qib7 2781 30 ) ) -RRB- cord-005453-4057qib7 2781 31 , , , cord-005453-4057qib7 2781 32 AKIN-2 AKIN-2 NNP cord-005453-4057qib7 2781 33 ( ( -LRB- cord-005453-4057qib7 2781 34 15 15 CD cord-005453-4057qib7 2781 35 % % NN cord-005453-4057qib7 2781 36 ) ) -RRB- cord-005453-4057qib7 2781 37 and and CC cord-005453-4057qib7 2781 38 AKIN-3 AKIN-3 NNP cord-005453-4057qib7 2781 39 ( ( -LRB- cord-005453-4057qib7 2781 40 16 16 CD cord-005453-4057qib7 2781 41 % % NN cord-005453-4057qib7 2781 42 ) ) -RRB- cord-005453-4057qib7 2781 43 ; ; : cord-005453-4057qib7 2782 1 p=0.006 p=0.006 NNS cord-005453-4057qib7 2782 2 . . . cord-005453-4057qib7 2783 1 Conclusions conclusion NNS cord-005453-4057qib7 2783 2 : : : cord-005453-4057qib7 2784 1 ARF ARF NNP cord-005453-4057qib7 2784 2 is be VBZ cord-005453-4057qib7 2784 3 a a DT cord-005453-4057qib7 2784 4 frequent frequent JJ cord-005453-4057qib7 2784 5 complication complication NN cord-005453-4057qib7 2784 6 during during IN cord-005453-4057qib7 2784 7 the the DT cord-005453-4057qib7 2784 8 first first JJ cord-005453-4057qib7 2784 9 year year NN cord-005453-4057qib7 2784 10 after after IN cord-005453-4057qib7 2784 11 allo allo NNP cord-005453-4057qib7 2784 12 - - HYPH cord-005453-4057qib7 2784 13 SCT SCT NNP cord-005453-4057qib7 2784 14 and and CC cord-005453-4057qib7 2784 15 is be VBZ cord-005453-4057qib7 2784 16 associated associate VBN cord-005453-4057qib7 2784 17 with with IN cord-005453-4057qib7 2784 18 several several JJ cord-005453-4057qib7 2784 19 factors factor NNS cord-005453-4057qib7 2784 20 . . . cord-005453-4057qib7 2785 1 ARF ARF NNP cord-005453-4057qib7 2785 2 AKIN-3 AKIN-3 NNP cord-005453-4057qib7 2785 3 was be VBD cord-005453-4057qib7 2785 4 associated associate VBN cord-005453-4057qib7 2785 5 with with IN cord-005453-4057qib7 2785 6 more more RBR cord-005453-4057qib7 2785 7 intensive intensive JJ cord-005453-4057qib7 2785 8 strategies strategy NNS cord-005453-4057qib7 2785 9 received receive VBN cord-005453-4057qib7 2785 10 during during IN cord-005453-4057qib7 2785 11 conditioning conditioning NN cord-005453-4057qib7 2785 12 , , , cord-005453-4057qib7 2785 13 meanwhile meanwhile RB cord-005453-4057qib7 2785 14 AKIN-1/2 AKIN-1/2 NNP cord-005453-4057qib7 2785 15 were be VBD cord-005453-4057qib7 2785 16 related relate VBN cord-005453-4057qib7 2785 17 to to IN cord-005453-4057qib7 2785 18 development development NN cord-005453-4057qib7 2785 19 of of IN cord-005453-4057qib7 2785 20 GvHD GvHD NNP cord-005453-4057qib7 2785 21 . . . cord-005453-4057qib7 2786 1 There there EX cord-005453-4057qib7 2786 2 is be VBZ cord-005453-4057qib7 2786 3 an an DT cord-005453-4057qib7 2786 4 association association NN cord-005453-4057qib7 2786 5 of of IN cord-005453-4057qib7 2786 6 ARF ARF NNP cord-005453-4057qib7 2786 7 ( ( -LRB- cord-005453-4057qib7 2786 8 AKIN-1 AKIN-1 NNP cord-005453-4057qib7 2786 9 , , , cord-005453-4057qib7 2786 10 2 2 CD cord-005453-4057qib7 2786 11 or or CC cord-005453-4057qib7 2786 12 3 3 CD cord-005453-4057qib7 2786 13 ) ) -RRB- cord-005453-4057qib7 2786 14 with with IN cord-005453-4057qib7 2786 15 development development NN cord-005453-4057qib7 2786 16 of of IN cord-005453-4057qib7 2786 17 chronic chronic JJ cord-005453-4057qib7 2786 18 renal renal JJ cord-005453-4057qib7 2786 19 disease disease NN cord-005453-4057qib7 2786 20 . . . cord-005453-4057qib7 2787 1 Background background NN cord-005453-4057qib7 2787 2 : : : cord-005453-4057qib7 2788 1 The the DT cord-005453-4057qib7 2788 2 introduction introduction NN cord-005453-4057qib7 2788 3 of of IN cord-005453-4057qib7 2788 4 cellular cellular JJ cord-005453-4057qib7 2788 5 therapies therapy NNS cord-005453-4057qib7 2788 6 such such JJ cord-005453-4057qib7 2788 7 as as IN cord-005453-4057qib7 2788 8 CAR car NN cord-005453-4057qib7 2788 9 - - HYPH cord-005453-4057qib7 2788 10 T T NNP cord-005453-4057qib7 2788 11 and and CC cord-005453-4057qib7 2788 12 modalities modality NNS cord-005453-4057qib7 2788 13 of of IN cord-005453-4057qib7 2788 14 GvHD gvhd NN cord-005453-4057qib7 2788 15 - - HYPH cord-005453-4057qib7 2788 16 prophylaxis prophylaxis NN cord-005453-4057qib7 2788 17 with with IN cord-005453-4057qib7 2788 18 posttransplant posttransplant NN cord-005453-4057qib7 2788 19 / / , cord-005453-4057qib7 2788 20 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 2788 21 ( ( -LRB- cord-005453-4057qib7 2788 22 PtCy ptcy RB cord-005453-4057qib7 2788 23 ) ) -RRB- cord-005453-4057qib7 2788 24 that that WDT cord-005453-4057qib7 2788 25 increase increase VBP cord-005453-4057qib7 2788 26 the the DT cord-005453-4057qib7 2788 27 number number NN cord-005453-4057qib7 2788 28 of of IN cord-005453-4057qib7 2788 29 admission admission NN cord-005453-4057qib7 2788 30 days day NNS cord-005453-4057qib7 2788 31 have have VBP cord-005453-4057qib7 2788 32 boosted boost VBN cord-005453-4057qib7 2788 33 the the DT cord-005453-4057qib7 2788 34 pressure pressure NN cord-005453-4057qib7 2788 35 of of IN cord-005453-4057qib7 2788 36 available available JJ cord-005453-4057qib7 2788 37 beds bed NNS cord-005453-4057qib7 2788 38 in in IN cord-005453-4057qib7 2788 39 the the DT cord-005453-4057qib7 2788 40 BM bm NN cord-005453-4057qib7 2788 41 - - HYPH cord-005453-4057qib7 2788 42 units unit NNS cord-005453-4057qib7 2788 43 . . . cord-005453-4057qib7 2789 1 In in IN cord-005453-4057qib7 2789 2 this this DT cord-005453-4057qib7 2789 3 sense sense NN cord-005453-4057qib7 2789 4 , , , cord-005453-4057qib7 2789 5 our -PRON- PRP$ cord-005453-4057qib7 2789 6 centre centre NN cord-005453-4057qib7 2789 7 started start VBD cord-005453-4057qib7 2789 8 an an DT cord-005453-4057qib7 2789 9 at at IN cord-005453-4057qib7 2789 10 - - HYPH cord-005453-4057qib7 2789 11 home home NN cord-005453-4057qib7 2789 12 allogeneic allogeneic NN cord-005453-4057qib7 2789 13 stem stem NN cord-005453-4057qib7 2789 14 cell cell NN cord-005453-4057qib7 2789 15 transplantation transplantation NN cord-005453-4057qib7 2789 16 ( ( -LRB- cord-005453-4057qib7 2789 17 allo allo FW cord-005453-4057qib7 2789 18 - - HYPH cord-005453-4057qib7 2789 19 SCT SCT NNP cord-005453-4057qib7 2789 20 ) ) -RRB- cord-005453-4057qib7 2789 21 program program NN cord-005453-4057qib7 2789 22 to to TO cord-005453-4057qib7 2789 23 follow follow VB cord-005453-4057qib7 2789 24 aplasia aplasia NNP cord-005453-4057qib7 2789 25 from from IN cord-005453-4057qib7 2789 26 the the DT cord-005453-4057qib7 2789 27 D+1 D+1 NNP cord-005453-4057qib7 2789 28 until until IN cord-005453-4057qib7 2789 29 independent independent JJ cord-005453-4057qib7 2789 30 ambulatory ambulatory JJ cord-005453-4057qib7 2789 31 patient patient NN cord-005453-4057qib7 2789 32 . . . cord-005453-4057qib7 2790 1 To to TO cord-005453-4057qib7 2790 2 evaluate evaluate VB cord-005453-4057qib7 2790 3 the the DT cord-005453-4057qib7 2790 4 feasibility feasibility NN cord-005453-4057qib7 2790 5 and and CC cord-005453-4057qib7 2790 6 safety safety NN cord-005453-4057qib7 2790 7 of of IN cord-005453-4057qib7 2790 8 alloSCT alloSCT NNP cord-005453-4057qib7 2790 9 , , , cord-005453-4057qib7 2790 10 we -PRON- PRP cord-005453-4057qib7 2790 11 compared compare VBD cord-005453-4057qib7 2790 12 two two CD cord-005453-4057qib7 2790 13 groups group NNS cord-005453-4057qib7 2790 14 : : : cord-005453-4057qib7 2790 15 alloHSCT alloHSCT NNP cord-005453-4057qib7 2790 16 / / SYM cord-005453-4057qib7 2790 17 athome athome NNP cord-005453-4057qib7 2790 18 ( ( -LRB- cord-005453-4057qib7 2790 19 AH AH NNP cord-005453-4057qib7 2790 20 - - HYPH cord-005453-4057qib7 2790 21 Group Group NNP cord-005453-4057qib7 2790 22 ) ) -RRB- cord-005453-4057qib7 2790 23 vs. vs. FW cord-005453-4057qib7 2790 24 alloHSCT alloHSCT NNP cord-005453-4057qib7 2790 25 / / SYM cord-005453-4057qib7 2790 26 in in IN cord-005453-4057qib7 2790 27 - - HYPH cord-005453-4057qib7 2790 28 patient patient NN cord-005453-4057qib7 2790 29 ( ( -LRB- cord-005453-4057qib7 2790 30 IP IP NNP cord-005453-4057qib7 2790 31 - - HYPH cord-005453-4057qib7 2790 32 Group Group NNP cord-005453-4057qib7 2790 33 ) ) -RRB- cord-005453-4057qib7 2790 34 . . . cord-005453-4057qib7 2791 1 Methods method NNS cord-005453-4057qib7 2791 2 : : : cord-005453-4057qib7 2792 1 We -PRON- PRP cord-005453-4057qib7 2792 2 included include VBD cord-005453-4057qib7 2792 3 78 78 CD cord-005453-4057qib7 2792 4 patients patient NNS cord-005453-4057qib7 2792 5 receiving receive VBG cord-005453-4057qib7 2792 6 alloSCT alloSCT NNP cord-005453-4057qib7 2792 7 ( ( -LRB- cord-005453-4057qib7 2792 8 January January NNP cord-005453-4057qib7 2792 9 2014-November 2014-november CD cord-005453-4057qib7 2792 10 2018 2018 CD cord-005453-4057qib7 2792 11 ) ) -RRB- cord-005453-4057qib7 2792 12 in in IN cord-005453-4057qib7 2792 13 a a DT cord-005453-4057qib7 2792 14 single single JJ cord-005453-4057qib7 2792 15 centre centre NN cord-005453-4057qib7 2792 16 : : : cord-005453-4057qib7 2792 17 39 39 CD cord-005453-4057qib7 2792 18 patients patient NNS cord-005453-4057qib7 2792 19 , , , cord-005453-4057qib7 2792 20 AH AH NNP cord-005453-4057qib7 2792 21 - - HYPH cord-005453-4057qib7 2792 22 Group Group NNP cord-005453-4057qib7 2792 23 and and CC cord-005453-4057qib7 2792 24 39 39 CD cord-005453-4057qib7 2792 25 , , , cord-005453-4057qib7 2792 26 IP IP NNP cord-005453-4057qib7 2792 27 - - HYPH cord-005453-4057qib7 2792 28 Group Group NNP cord-005453-4057qib7 2792 29 . . . cord-005453-4057qib7 2793 1 All all DT cord-005453-4057qib7 2793 2 patients patient NNS cord-005453-4057qib7 2793 3 received receive VBD cord-005453-4057qib7 2793 4 conditioning conditioning NN cord-005453-4057qib7 2793 5 at at IN cord-005453-4057qib7 2793 6 the the DT cord-005453-4057qib7 2793 7 hospital hospital NN cord-005453-4057qib7 2793 8 . . . cord-005453-4057qib7 2794 1 GvHD gvhd NN cord-005453-4057qib7 2794 2 - - HYPH cord-005453-4057qib7 2794 3 prophylaxis prophylaxis NN cord-005453-4057qib7 2794 4 consisted consist VBN cord-005453-4057qib7 2794 5 in in IN cord-005453-4057qib7 2794 6 tacrolimus tacrolimus NNP cord-005453-4057qib7 2794 7 ( ( -LRB- cord-005453-4057qib7 2794 8 TK TK NNP cord-005453-4057qib7 2794 9 ) ) -RRB- cord-005453-4057qib7 2794 10 plus plus CC cord-005453-4057qib7 2794 11 mycophenolate mycophenolate NNP cord-005453-4057qib7 2794 12 ( ( -LRB- cord-005453-4057qib7 2794 13 MPM MPM NNP cord-005453-4057qib7 2794 14 ) ) -RRB- cord-005453-4057qib7 2794 15 or or CC cord-005453-4057qib7 2794 16 methotrexate methotrexate NNP cord-005453-4057qib7 2794 17 , , , cord-005453-4057qib7 2794 18 or or CC cord-005453-4057qib7 2794 19 PtCy ptcy NN cord-005453-4057qib7 2795 1 ( ( -LRB- cord-005453-4057qib7 2795 2 D+3 D+3 NNP cord-005453-4057qib7 2795 3 , , , cord-005453-4057qib7 2795 4 D+4 D+4 NNP cord-005453-4057qib7 2795 5 ) ) -RRB- cord-005453-4057qib7 2795 6 plus plus CC cord-005453-4057qib7 2795 7 TK TK NNP cord-005453-4057qib7 2795 8 ( ( -LRB- cord-005453-4057qib7 2795 9 D+5 D+5 NNP cord-005453-4057qib7 2795 10 ) ) -RRB- cord-005453-4057qib7 2795 11 . . . cord-005453-4057qib7 2796 1 All all DT cord-005453-4057qib7 2796 2 patients patient NNS cord-005453-4057qib7 2796 3 received receive VBD cord-005453-4057qib7 2796 4 prophylaxis prophylaxis NN cord-005453-4057qib7 2796 5 with with IN cord-005453-4057qib7 2796 6 levofloxacin levofloxacin NNS cord-005453-4057qib7 2796 7 , , , cord-005453-4057qib7 2796 8 fluconazole fluconazole NN cord-005453-4057qib7 2796 9 and and CC cord-005453-4057qib7 2796 10 acyclovir acyclovir NN cord-005453-4057qib7 2796 11 . . . cord-005453-4057qib7 2797 1 Besides besides IN cord-005453-4057qib7 2797 2 that that DT cord-005453-4057qib7 2797 3 , , , cord-005453-4057qib7 2797 4 AH AH NNP cord-005453-4057qib7 2797 5 - - HYPH cord-005453-4057qib7 2797 6 Group Group NNP cord-005453-4057qib7 2797 7 patients patient NNS cord-005453-4057qib7 2797 8 received receive VBD cord-005453-4057qib7 2797 9 prophylaxis prophylaxis NN cord-005453-4057qib7 2797 10 with with IN cord-005453-4057qib7 2797 11 ceftriaxone ceftriaxone NN cord-005453-4057qib7 2797 12 1g/24h 1g/24h CD cord-005453-4057qib7 2797 13 IV IV NNP cord-005453-4057qib7 2797 14 or or CC cord-005453-4057qib7 2797 15 ertapenem ertapenem NNP cord-005453-4057qib7 2797 16 1g/ 1g/ CD cord-005453-4057qib7 2797 17 24h 24h CD cord-005453-4057qib7 2797 18 IV IV NNP cord-005453-4057qib7 2797 19 , , , cord-005453-4057qib7 2797 20 and and CC cord-005453-4057qib7 2797 21 Aspergillus aspergillus NN cord-005453-4057qib7 2797 22 - - HYPH cord-005453-4057qib7 2797 23 prophylaxis prophylaxis NN cord-005453-4057qib7 2797 24 with with IN cord-005453-4057qib7 2797 25 inhaled inhale VBN cord-005453-4057qib7 2797 26 liposomal liposomal JJ cord-005453-4057qib7 2797 27 amphotericin amphotericin NN cord-005453-4057qib7 2797 28 - - HYPH cord-005453-4057qib7 2797 29 B B NNP cord-005453-4057qib7 2797 30 or or CC cord-005453-4057qib7 2797 31 posaconazole posaconazole NN cord-005453-4057qib7 2797 32 during during IN cord-005453-4057qib7 2797 33 neutropenia neutropenia NN cord-005453-4057qib7 2797 34 . . . cord-005453-4057qib7 2798 1 Patients patient NNS cord-005453-4057qib7 2798 2 of of IN cord-005453-4057qib7 2798 3 AH AH NNP cord-005453-4057qib7 2798 4 - - HYPH cord-005453-4057qib7 2798 5 Group Group NNP cord-005453-4057qib7 2798 6 since since IN cord-005453-4057qib7 2798 7 D+1 D+1 NNP cord-005453-4057qib7 2798 8 or or CC cord-005453-4057qib7 2798 9 D+6 D+6 NNP cord-005453-4057qib7 2798 10 ( ( -LRB- cord-005453-4057qib7 2798 11 in in IN cord-005453-4057qib7 2798 12 PtCyprophylaxis PtCyprophylaxis NNP cord-005453-4057qib7 2798 13 ) ) -RRB- cord-005453-4057qib7 2798 14 received receive VBD cord-005453-4057qib7 2798 15 a a DT cord-005453-4057qib7 2798 16 nurse nurse NN cord-005453-4057qib7 2798 17 visit visit NN cord-005453-4057qib7 2798 18 at at IN cord-005453-4057qib7 2798 19 - - HYPH cord-005453-4057qib7 2798 20 home home NN cord-005453-4057qib7 2798 21 once once RB cord-005453-4057qib7 2798 22 daily daily RB cord-005453-4057qib7 2798 23 . . . cord-005453-4057qib7 2799 1 The the DT cord-005453-4057qib7 2799 2 visits visit NNS cord-005453-4057qib7 2799 3 by by IN cord-005453-4057qib7 2799 4 the the DT cord-005453-4057qib7 2799 5 physician physician NN cord-005453-4057qib7 2799 6 were be VBD cord-005453-4057qib7 2799 7 performed perform VBN cord-005453-4057qib7 2799 8 at at IN cord-005453-4057qib7 2799 9 the the DT cord-005453-4057qib7 2799 10 hospital hospital NN cord-005453-4057qib7 2799 11 and and CC cord-005453-4057qib7 2799 12 only only RB cord-005453-4057qib7 2799 13 during during IN cord-005453-4057qib7 2799 14 complication complication NN cord-005453-4057qib7 2799 15 events event NNS cord-005453-4057qib7 2799 16 . . . cord-005453-4057qib7 2800 1 First first JJ cord-005453-4057qib7 2800 2 - - HYPH cord-005453-4057qib7 2800 3 line line NN cord-005453-4057qib7 2800 4 therapy therapy NN cord-005453-4057qib7 2800 5 of of IN cord-005453-4057qib7 2800 6 neutropenic neutropenic JJ cord-005453-4057qib7 2800 7 fever fever NN cord-005453-4057qib7 2800 8 was be VBD cord-005453-4057qib7 2800 9 meropenem meropenem NNP cord-005453-4057qib7 2800 10 1 1 CD cord-005453-4057qib7 2800 11 g/8h g/8h NNP cord-005453-4057qib7 2800 12 in in IN cord-005453-4057qib7 2800 13 both both DT cord-005453-4057qib7 2800 14 groups group NNS cord-005453-4057qib7 2800 15 , , , cord-005453-4057qib7 2800 16 using use VBG cord-005453-4057qib7 2800 17 a a DT cord-005453-4057qib7 2800 18 portable portable JJ cord-005453-4057qib7 2800 19 infusion infusion NN cord-005453-4057qib7 2800 20 pump pump NN cord-005453-4057qib7 2800 21 in in IN cord-005453-4057qib7 2800 22 AH AH NNP cord-005453-4057qib7 2800 23 - - HYPH cord-005453-4057qib7 2800 24 Group Group NNP cord-005453-4057qib7 2800 25 . . . cord-005453-4057qib7 2801 1 In in IN cord-005453-4057qib7 2801 2 this this DT cord-005453-4057qib7 2801 3 group group NN cord-005453-4057qib7 2801 4 , , , cord-005453-4057qib7 2801 5 the the DT cord-005453-4057qib7 2801 6 absence absence NN cord-005453-4057qib7 2801 7 of of IN cord-005453-4057qib7 2801 8 focal focal JJ cord-005453-4057qib7 2801 9 infection infection NN cord-005453-4057qib7 2801 10 or or CC cord-005453-4057qib7 2801 11 signs sign NNS cord-005453-4057qib7 2801 12 of of IN cord-005453-4057qib7 2801 13 severe severe JJ cord-005453-4057qib7 2801 14 sepsis sepsis NN cord-005453-4057qib7 2801 15 allowed allow VBD cord-005453-4057qib7 2801 16 returning return VBG cord-005453-4057qib7 2801 17 home home RB cord-005453-4057qib7 2801 18 after after IN cord-005453-4057qib7 2801 19 the the DT cord-005453-4057qib7 2801 20 initiation initiation NN cord-005453-4057qib7 2801 21 of of IN cord-005453-4057qib7 2801 22 antibiotics antibiotic NNS cord-005453-4057qib7 2801 23 . . . cord-005453-4057qib7 2802 1 The the DT cord-005453-4057qib7 2802 2 platelets platelet NNS cord-005453-4057qib7 2802 3 support support NN cord-005453-4057qib7 2802 4 was be VBD cord-005453-4057qib7 2802 5 performed perform VBN cord-005453-4057qib7 2802 6 at at IN cord-005453-4057qib7 2802 7 - - HYPH cord-005453-4057qib7 2802 8 home home NN cord-005453-4057qib7 2802 9 and and CC cord-005453-4057qib7 2802 10 the the DT cord-005453-4057qib7 2802 11 red red JJ cord-005453-4057qib7 2802 12 blood blood NN cord-005453-4057qib7 2802 13 support support NN cord-005453-4057qib7 2802 14 at at IN cord-005453-4057qib7 2802 15 hospital hospital NN cord-005453-4057qib7 2802 16 . . . cord-005453-4057qib7 2803 1 Results result NNS cord-005453-4057qib7 2803 2 : : : cord-005453-4057qib7 2804 1 The the DT cord-005453-4057qib7 2804 2 median median NN cord-005453-4057qib7 2804 3 ( ( -LRB- cord-005453-4057qib7 2804 4 range range NN cord-005453-4057qib7 2804 5 ) ) -RRB- cord-005453-4057qib7 2804 6 age age NN cord-005453-4057qib7 2804 7 ( ( -LRB- cord-005453-4057qib7 2804 8 years year NNS cord-005453-4057qib7 2804 9 ) ) -RRB- cord-005453-4057qib7 2804 10 of of IN cord-005453-4057qib7 2804 11 the the DT cord-005453-4057qib7 2804 12 series series NN cord-005453-4057qib7 2804 13 was be VBD cord-005453-4057qib7 2804 14 54 54 CD cord-005453-4057qib7 2804 15 . . . cord-005453-4057qib7 2805 1 The the DT cord-005453-4057qib7 2805 2 median median JJ cord-005453-4057qib7 2805 3 follow follow NN cord-005453-4057qib7 2805 4 - - HYPH cord-005453-4057qib7 2805 5 up up NN cord-005453-4057qib7 2805 6 of of IN cord-005453-4057qib7 2805 7 the the DT cord-005453-4057qib7 2805 8 series series NN cord-005453-4057qib7 2805 9 has have VBZ cord-005453-4057qib7 2805 10 been be VBN cord-005453-4057qib7 2805 11 not not RB cord-005453-4057qib7 2805 12 achieved achieve VBN cord-005453-4057qib7 2805 13 . . . cord-005453-4057qib7 2806 1 The the DT cord-005453-4057qib7 2806 2 source source NN cord-005453-4057qib7 2806 3 of of IN cord-005453-4057qib7 2806 4 the the DT cord-005453-4057qib7 2806 5 SCT SCT NNP cord-005453-4057qib7 2806 6 was be VBD cord-005453-4057qib7 2806 7 peripheral peripheral JJ cord-005453-4057qib7 2806 8 blood blood NN cord-005453-4057qib7 2806 9 in in IN cord-005453-4057qib7 2806 10 all all DT cord-005453-4057qib7 2806 11 cases case NNS cord-005453-4057qib7 2806 12 . . . cord-005453-4057qib7 2807 1 We -PRON- PRP cord-005453-4057qib7 2807 2 did do VBD cord-005453-4057qib7 2807 3 n't not RB cord-005453-4057qib7 2807 4 find find VB cord-005453-4057qib7 2807 5 statistical statistical JJ cord-005453-4057qib7 2807 6 differences difference NNS cord-005453-4057qib7 2807 7 between between IN cord-005453-4057qib7 2807 8 two two CD cord-005453-4057qib7 2807 9 groups group NNS cord-005453-4057qib7 2807 10 ( ( -LRB- cord-005453-4057qib7 2807 11 AH ah NN cord-005453-4057qib7 2807 12 vs vs IN cord-005453-4057qib7 2807 13 IP IP NNP cord-005453-4057qib7 2807 14 ) ) -RRB- cord-005453-4057qib7 2807 15 in in IN cord-005453-4057qib7 2807 16 terms term NNS cord-005453-4057qib7 2807 17 of of IN cord-005453-4057qib7 2807 18 age age NN cord-005453-4057qib7 2807 19 , , , cord-005453-4057qib7 2807 20 diagnosis diagnosis NN cord-005453-4057qib7 2807 21 , , , cord-005453-4057qib7 2807 22 type type NN cord-005453-4057qib7 2807 23 of of IN cord-005453-4057qib7 2807 24 donor donor NN cord-005453-4057qib7 2807 25 , , , cord-005453-4057qib7 2807 26 intensity intensity NN cord-005453-4057qib7 2807 27 of of IN cord-005453-4057qib7 2807 28 conditioning conditioning NN cord-005453-4057qib7 2807 29 , , , cord-005453-4057qib7 2807 30 GvHD gvhd NN cord-005453-4057qib7 2807 31 - - HYPH cord-005453-4057qib7 2807 32 prophylaxis prophylaxis NN cord-005453-4057qib7 2807 33 , , , cord-005453-4057qib7 2807 34 toxicity toxicity NN cord-005453-4057qib7 2807 35 ( ( -LRB- cord-005453-4057qib7 2807 36 mucositis mucositis NNP cord-005453-4057qib7 2807 37 , , , cord-005453-4057qib7 2807 38 acute acute JJ cord-005453-4057qib7 2807 39 renal renal JJ cord-005453-4057qib7 2807 40 injury injury NN cord-005453-4057qib7 2807 41 , , , cord-005453-4057qib7 2807 42 neutropenia neutropenia NN cord-005453-4057qib7 2807 43 and and CC cord-005453-4057qib7 2807 44 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2807 45 ) ) -RRB- cord-005453-4057qib7 2807 46 , , , cord-005453-4057qib7 2807 47 aGvHD aGvHD NNP cord-005453-4057qib7 2807 48 , , , cord-005453-4057qib7 2807 49 Aspergilosis Aspergilosis NNP cord-005453-4057qib7 2807 50 and and CC cord-005453-4057qib7 2807 51 TRM TRM NNP cord-005453-4057qib7 2807 52 . . . cord-005453-4057qib7 2808 1 Interestingly interestingly RB cord-005453-4057qib7 2808 2 , , , cord-005453-4057qib7 2808 3 a a DT cord-005453-4057qib7 2808 4 significant significant JJ cord-005453-4057qib7 2808 5 reduction reduction NN cord-005453-4057qib7 2808 6 of of IN cord-005453-4057qib7 2808 7 neutropenic neutropenic JJ cord-005453-4057qib7 2808 8 fever fever NN cord-005453-4057qib7 2808 9 was be VBD cord-005453-4057qib7 2808 10 observed observe VBN cord-005453-4057qib7 2808 11 resulting result VBG cord-005453-4057qib7 2808 12 the the DT cord-005453-4057qib7 2808 13 lower low JJR cord-005453-4057qib7 2808 14 use use NN cord-005453-4057qib7 2808 15 of of IN cord-005453-4057qib7 2808 16 meropenem meropenem NN cord-005453-4057qib7 2808 17 in in IN cord-005453-4057qib7 2808 18 the the DT cord-005453-4057qib7 2808 19 AH AH NNP cord-005453-4057qib7 2808 20 - - HYPH cord-005453-4057qib7 2808 21 group group NN cord-005453-4057qib7 2808 22 than than IN cord-005453-4057qib7 2808 23 IP ip NN cord-005453-4057qib7 2808 24 - - HYPH cord-005453-4057qib7 2808 25 group group NN cord-005453-4057qib7 2808 26 . . . cord-005453-4057qib7 2809 1 The the DT cord-005453-4057qib7 2809 2 admission admission NN cord-005453-4057qib7 2809 3 median median JJ cord-005453-4057qib7 2809 4 days day NNS cord-005453-4057qib7 2809 5 were be VBD cord-005453-4057qib7 2809 6 similar similar JJ cord-005453-4057qib7 2809 7 in in IN cord-005453-4057qib7 2809 8 the the DT cord-005453-4057qib7 2809 9 both both DT cord-005453-4057qib7 2809 10 groups group NNS cord-005453-4057qib7 2809 11 and and CC cord-005453-4057qib7 2809 12 it -PRON- PRP cord-005453-4057qib7 2809 13 represented represent VBD cord-005453-4057qib7 2809 14 21 21 CD cord-005453-4057qib7 2809 15 - - SYM cord-005453-4057qib7 2809 16 23 23 CD cord-005453-4057qib7 2809 17 days day NNS cord-005453-4057qib7 2809 18 the the DT cord-005453-4057qib7 2809 19 reduction reduction NN cord-005453-4057qib7 2809 20 in in IN cord-005453-4057qib7 2809 21 the the DT cord-005453-4057qib7 2809 22 total total JJ cord-005453-4057qib7 2809 23 economic economic JJ cord-005453-4057qib7 2809 24 cost cost NN cord-005453-4057qib7 2809 25 of of IN cord-005453-4057qib7 2809 26 the the DT cord-005453-4057qib7 2809 27 AH ah NN cord-005453-4057qib7 2809 28 - - HYPH cord-005453-4057qib7 2809 29 group group NN cord-005453-4057qib7 2809 30 . . . cord-005453-4057qib7 2810 1 The the DT cord-005453-4057qib7 2810 2 whole whole JJ cord-005453-4057qib7 2810 3 analysis analysis NN cord-005453-4057qib7 2810 4 of of IN cord-005453-4057qib7 2810 5 the the DT cord-005453-4057qib7 2810 6 results result NNS cord-005453-4057qib7 2810 7 are be VBP cord-005453-4057qib7 2810 8 detailed detail VBN cord-005453-4057qib7 2810 9 in in IN cord-005453-4057qib7 2810 10 table table NN cord-005453-4057qib7 2810 11 : : : cord-005453-4057qib7 2810 12 In in IN cord-005453-4057qib7 2810 13 - - HYPH cord-005453-4057qib7 2810 14 Patient Patient NNP cord-005453-4057qib7 2810 15 Group Group NNP cord-005453-4057qib7 2810 16 , , , cord-005453-4057qib7 2810 17 Conclusions Conclusions NNPS cord-005453-4057qib7 2810 18 : : : cord-005453-4057qib7 2810 19 In in IN cord-005453-4057qib7 2810 20 our -PRON- PRP$ cord-005453-4057qib7 2810 21 experience experience NN cord-005453-4057qib7 2810 22 , , , cord-005453-4057qib7 2810 23 at at IN cord-005453-4057qib7 2810 24 home home NN cord-005453-4057qib7 2810 25 alloSCT alloSCT NNP cord-005453-4057qib7 2810 26 , , , cord-005453-4057qib7 2810 27 including include VBG cord-005453-4057qib7 2810 28 PtCy ptcy RB cord-005453-4057qib7 2810 29 - - HYPH cord-005453-4057qib7 2810 30 GvHD GvHD VBG cord-005453-4057qib7 2810 31 prophylaxis prophylaxis NN cord-005453-4057qib7 2810 32 , , , cord-005453-4057qib7 2810 33 is be VBZ cord-005453-4057qib7 2810 34 a a DT cord-005453-4057qib7 2810 35 feasible feasible JJ cord-005453-4057qib7 2810 36 and and CC cord-005453-4057qib7 2810 37 safe safe JJ cord-005453-4057qib7 2810 38 procedure procedure NN cord-005453-4057qib7 2810 39 reflected reflect VBN cord-005453-4057qib7 2810 40 in in IN cord-005453-4057qib7 2810 41 similar similar JJ cord-005453-4057qib7 2810 42 TRM TRM NNP cord-005453-4057qib7 2810 43 and and CC cord-005453-4057qib7 2810 44 Aspergillosis Aspergillosis NNP cord-005453-4057qib7 2810 45 incidence incidence NN cord-005453-4057qib7 2810 46 . . . cord-005453-4057qib7 2811 1 At at IN cord-005453-4057qib7 2811 2 - - HYPH cord-005453-4057qib7 2811 3 home home NN cord-005453-4057qib7 2811 4 allo allo NN cord-005453-4057qib7 2811 5 - - HYPH cord-005453-4057qib7 2811 6 SCT SCT NNP cord-005453-4057qib7 2811 7 is be VBZ cord-005453-4057qib7 2811 8 associated associate VBN cord-005453-4057qib7 2811 9 with with IN cord-005453-4057qib7 2811 10 a a DT cord-005453-4057qib7 2811 11 significant significant JJ cord-005453-4057qib7 2811 12 lower low JJR cord-005453-4057qib7 2811 13 risk risk NN cord-005453-4057qib7 2811 14 of of IN cord-005453-4057qib7 2811 15 neutropenic neutropenic JJ cord-005453-4057qib7 2811 16 fever fever NN cord-005453-4057qib7 2811 17 than than IN cord-005453-4057qib7 2811 18 in in IN cord-005453-4057qib7 2811 19 - - HYPH cord-005453-4057qib7 2811 20 patient patient NN cord-005453-4057qib7 2811 21 group group NN cord-005453-4057qib7 2811 22 , , , cord-005453-4057qib7 2811 23 as as RB cord-005453-4057qib7 2811 24 well well RB cord-005453-4057qib7 2811 25 as as IN cord-005453-4057qib7 2811 26 a a DT cord-005453-4057qib7 2811 27 very very RB cord-005453-4057qib7 2811 28 low low JJ cord-005453-4057qib7 2811 29 readmission readmission NN cord-005453-4057qib7 2811 30 rate rate NN cord-005453-4057qib7 2811 31 . . . cord-005453-4057qib7 2812 1 Disclosure disclosure NN cord-005453-4057qib7 2812 2 : : : cord-005453-4057qib7 2812 3 Gonzalo Gonzalo NNP cord-005453-4057qib7 2812 4 Gutiérrez Gutiérrez NNP cord-005453-4057qib7 2812 5 - - HYPH cord-005453-4057qib7 2812 6 García García NNP cord-005453-4057qib7 2812 7 : : : cord-005453-4057qib7 2812 8 honoraria honorarium NNS cord-005453-4057qib7 2812 9 from from IN cord-005453-4057qib7 2812 10 Gilead Gilead NNP cord-005453-4057qib7 2812 11 . . . cord-005453-4057qib7 2813 1 Grant grant VB cord-005453-4057qib7 2813 2 from from IN cord-005453-4057qib7 2813 3 Jazz Jazz NNP cord-005453-4057qib7 2813 4 Pharmaceutical Pharmaceutical NNP cord-005453-4057qib7 2813 5 and and CC cord-005453-4057qib7 2813 6 Janssen Janssen NNP cord-005453-4057qib7 2813 7 . . . cord-005453-4057qib7 2814 1 Laura Laura NNP cord-005453-4057qib7 2814 2 Rosiñol Rosiñol NNP cord-005453-4057qib7 2814 3 : : : cord-005453-4057qib7 2814 4 honoraria honorarium NNS cord-005453-4057qib7 2814 5 from from IN cord-005453-4057qib7 2814 6 Takeda Takeda NNP cord-005453-4057qib7 2814 7 , , , cord-005453-4057qib7 2814 8 Janssen Janssen NNP cord-005453-4057qib7 2814 9 , , , cord-005453-4057qib7 2814 10 Amgen Amgen NNP cord-005453-4057qib7 2814 11 and and CC cord-005453-4057qib7 2814 12 Celgene Celgene NNP cord-005453-4057qib7 2814 13 . . . cord-005453-4057qib7 2815 1 The the DT cord-005453-4057qib7 2815 2 others other NNS cord-005453-4057qib7 2815 3 author author NN cord-005453-4057qib7 2815 4 do do VBP cord-005453-4057qib7 2815 5 not not RB cord-005453-4057qib7 2815 6 have have VB cord-005453-4057qib7 2815 7 any any DT cord-005453-4057qib7 2815 8 disclosures disclosure NNS cord-005453-4057qib7 2815 9 to to TO cord-005453-4057qib7 2815 10 declare declare VB cord-005453-4057qib7 2815 11 . . . cord-005453-4057qib7 2816 1 Background background NN cord-005453-4057qib7 2816 2 : : : cord-005453-4057qib7 2817 1 Renal renal JJ cord-005453-4057qib7 2817 2 complications complication NNS cord-005453-4057qib7 2817 3 in in IN cord-005453-4057qib7 2817 4 sickle sickle NN cord-005453-4057qib7 2817 5 cell cell NN cord-005453-4057qib7 2817 6 disease disease NN cord-005453-4057qib7 2817 7 ( ( -LRB- cord-005453-4057qib7 2817 8 SCD SCD NNP cord-005453-4057qib7 2817 9 ) ) -RRB- cord-005453-4057qib7 2817 10 include include VBP cord-005453-4057qib7 2817 11 episodes episode NNS cord-005453-4057qib7 2817 12 of of IN cord-005453-4057qib7 2817 13 acute acute JJ cord-005453-4057qib7 2817 14 kidney kidney NN cord-005453-4057qib7 2817 15 injury injury NN cord-005453-4057qib7 2817 16 ( ( -LRB- cord-005453-4057qib7 2817 17 AKI AKI NNP cord-005453-4057qib7 2817 18 ) ) -RRB- cord-005453-4057qib7 2817 19 , , , cord-005453-4057qib7 2817 20 progressive progressive JJ cord-005453-4057qib7 2817 21 chronic chronic JJ cord-005453-4057qib7 2817 22 kidney kidney NN cord-005453-4057qib7 2817 23 disease disease NN cord-005453-4057qib7 2817 24 ( ( -LRB- cord-005453-4057qib7 2817 25 CKD CKD NNP cord-005453-4057qib7 2817 26 ) ) -RRB- cord-005453-4057qib7 2817 27 and and CC cord-005453-4057qib7 2817 28 hyperfiltration hyperfiltration NN cord-005453-4057qib7 2817 29 , , , cord-005453-4057qib7 2817 30 defined define VBN cord-005453-4057qib7 2817 31 by by IN cord-005453-4057qib7 2817 32 abnormally abnormally RB cord-005453-4057qib7 2817 33 high high JJ cord-005453-4057qib7 2817 34 glomerular glomerular JJ cord-005453-4057qib7 2817 35 filtration filtration NN cord-005453-4057qib7 2817 36 rates rate NNS cord-005453-4057qib7 2817 37 ( ( -LRB- cord-005453-4057qib7 2817 38 GFRs gfr NNS cord-005453-4057qib7 2817 39 ) ) -RRB- cord-005453-4057qib7 2817 40 . . . cord-005453-4057qib7 2818 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 2818 2 stem stem NN cord-005453-4057qib7 2818 3 cell cell NN cord-005453-4057qib7 2818 4 transplant transplant NN cord-005453-4057qib7 2818 5 ( ( -LRB- cord-005453-4057qib7 2818 6 HSCT HSCT NNP cord-005453-4057qib7 2818 7 ) ) -RRB- cord-005453-4057qib7 2818 8 from from IN cord-005453-4057qib7 2818 9 an an DT cord-005453-4057qib7 2818 10 HLA HLA NNP cord-005453-4057qib7 2818 11 identical identical JJ cord-005453-4057qib7 2818 12 sibling sibling NN cord-005453-4057qib7 2818 13 donor donor NN cord-005453-4057qib7 2818 14 is be VBZ cord-005453-4057qib7 2818 15 a a DT cord-005453-4057qib7 2818 16 well well RB cord-005453-4057qib7 2818 17 - - HYPH cord-005453-4057qib7 2818 18 established establish VBN cord-005453-4057qib7 2818 19 curative curative JJ cord-005453-4057qib7 2818 20 treatment treatment NN cord-005453-4057qib7 2818 21 for for IN cord-005453-4057qib7 2818 22 SCD SCD NNP cord-005453-4057qib7 2818 23 , , , cord-005453-4057qib7 2818 24 but but CC cord-005453-4057qib7 2818 25 traditional traditional JJ cord-005453-4057qib7 2818 26 myeloablative myeloablative JJ cord-005453-4057qib7 2818 27 conditioning conditioning NN cord-005453-4057qib7 2818 28 ( ( -LRB- cord-005453-4057qib7 2818 29 MAC MAC NNP cord-005453-4057qib7 2818 30 ) ) -RRB- cord-005453-4057qib7 2818 31 regimens regimen NNS cord-005453-4057qib7 2818 32 pose pose VBP cord-005453-4057qib7 2818 33 risks risk NNS cord-005453-4057qib7 2818 34 of of IN cord-005453-4057qib7 2818 35 kidney kidney NN cord-005453-4057qib7 2818 36 injury injury NN cord-005453-4057qib7 2818 37 due due IN cord-005453-4057qib7 2818 38 to to IN cord-005453-4057qib7 2818 39 intensive intensive JJ cord-005453-4057qib7 2818 40 use use NN cord-005453-4057qib7 2818 41 of of IN cord-005453-4057qib7 2818 42 chemotherapeutic chemotherapeutic JJ cord-005453-4057qib7 2818 43 agents agent NNS cord-005453-4057qib7 2818 44 , , , cord-005453-4057qib7 2818 45 infectious infectious JJ cord-005453-4057qib7 2818 46 risks risk NNS cord-005453-4057qib7 2818 47 , , , cord-005453-4057qib7 2818 48 and and CC cord-005453-4057qib7 2818 49 use use NN cord-005453-4057qib7 2818 50 of of IN cord-005453-4057qib7 2818 51 calcineurin calcineurin NNP cord-005453-4057qib7 2818 52 inhibitors inhibitor NNS cord-005453-4057qib7 2818 53 ( ( -LRB- cord-005453-4057qib7 2818 54 CNIs CNIs NNP cord-005453-4057qib7 2818 55 ) ) -RRB- cord-005453-4057qib7 2818 56 . . . cord-005453-4057qib7 2819 1 AKI AKI NNP cord-005453-4057qib7 2819 2 and and CC cord-005453-4057qib7 2819 3 subsequent subsequent JJ cord-005453-4057qib7 2819 4 fluid fluid JJ cord-005453-4057qib7 2819 5 overload overload NN cord-005453-4057qib7 2819 6 ( ( -LRB- cord-005453-4057qib7 2819 7 FO FO NNP cord-005453-4057qib7 2819 8 ) ) -RRB- cord-005453-4057qib7 2819 9 are be VBP cord-005453-4057qib7 2819 10 common common JJ cord-005453-4057qib7 2819 11 in in IN cord-005453-4057qib7 2819 12 pediatric pediatric JJ cord-005453-4057qib7 2819 13 HSCT HSCT NNP cord-005453-4057qib7 2819 14 with with IN cord-005453-4057qib7 2819 15 reported report VBN cord-005453-4057qib7 2819 16 AKI AKI NNP cord-005453-4057qib7 2819 17 incidence incidence NN cord-005453-4057qib7 2819 18 of of IN cord-005453-4057qib7 2819 19 21%-50 21%-50 CD cord-005453-4057qib7 2819 20 % % NN cord-005453-4057qib7 2819 21 ( ( -LRB- cord-005453-4057qib7 2819 22 Kyung Kyung NNP cord-005453-4057qib7 2819 23 - - HYPH cord-005453-4057qib7 2819 24 Nam Nam NNP cord-005453-4057qib7 2819 25 Koh Koh NNP cord-005453-4057qib7 2819 26 et et NNP cord-005453-4057qib7 2819 27 . . . cord-005453-4057qib7 2820 1 Al Al NNP cord-005453-4057qib7 2820 2 . . NNP cord-005453-4057qib7 2820 3 , , , cord-005453-4057qib7 2820 4 2017 2017 CD cord-005453-4057qib7 2820 5 ) ) -RRB- cord-005453-4057qib7 2820 6 . . . cord-005453-4057qib7 2821 1 We -PRON- PRP cord-005453-4057qib7 2821 2 report report VBP cord-005453-4057qib7 2821 3 renal renal JJ cord-005453-4057qib7 2821 4 outcomes outcome NNS cord-005453-4057qib7 2821 5 in in IN cord-005453-4057qib7 2821 6 pediatric pediatric JJ cord-005453-4057qib7 2821 7 patients patient NNS cord-005453-4057qib7 2821 8 with with IN cord-005453-4057qib7 2821 9 SCD SCD NNP cord-005453-4057qib7 2821 10 who who WP cord-005453-4057qib7 2821 11 received receive VBD cord-005453-4057qib7 2821 12 HSCT HSCT NNP cord-005453-4057qib7 2821 13 following follow VBG cord-005453-4057qib7 2821 14 a a DT cord-005453-4057qib7 2821 15 non non JJ cord-005453-4057qib7 2821 16 - - JJ cord-005453-4057qib7 2821 17 myeloablative myeloablative JJ cord-005453-4057qib7 2821 18 conditioning conditioning NN cord-005453-4057qib7 2821 19 ( ( -LRB- cord-005453-4057qib7 2821 20 NMA NMA NNP cord-005453-4057qib7 2821 21 ) ) -RRB- cord-005453-4057qib7 2821 22 regimen regimen NN cord-005453-4057qib7 2821 23 without without IN cord-005453-4057qib7 2821 24 CNI CNI NNP cord-005453-4057qib7 2821 25 exposure exposure NN cord-005453-4057qib7 2821 26 . . . cord-005453-4057qib7 2822 1 Methods method NNS cord-005453-4057qib7 2822 2 : : : cord-005453-4057qib7 2823 1 Retrospective retrospective JJ cord-005453-4057qib7 2823 2 chart chart NN cord-005453-4057qib7 2823 3 review review NN cord-005453-4057qib7 2823 4 describing describe VBG cord-005453-4057qib7 2823 5 renal renal JJ cord-005453-4057qib7 2823 6 outcomes outcome NNS cord-005453-4057qib7 2823 7 in in IN cord-005453-4057qib7 2823 8 pediatric pediatric JJ cord-005453-4057qib7 2823 9 patients patient NNS cord-005453-4057qib7 2823 10 ( ( -LRB- cord-005453-4057qib7 2823 11 18 18 CD cord-005453-4057qib7 2823 12 years year NNS cord-005453-4057qib7 2823 13 of of IN cord-005453-4057qib7 2823 14 age age NN cord-005453-4057qib7 2823 15 or or CC cord-005453-4057qib7 2823 16 younger young JJR cord-005453-4057qib7 2823 17 ) ) -RRB- cord-005453-4057qib7 2823 18 with with IN cord-005453-4057qib7 2823 19 SCD SCD NNP cord-005453-4057qib7 2823 20 ( ( -LRB- cord-005453-4057qib7 2823 21 HbSS HbSS NNP cord-005453-4057qib7 2823 22 ) ) -RRB- cord-005453-4057qib7 2823 23 who who WP cord-005453-4057qib7 2823 24 underwent undergo VBD cord-005453-4057qib7 2823 25 NMA NMA NNP cord-005453-4057qib7 2823 26 HSCT HSCT NNP cord-005453-4057qib7 2823 27 in in IN cord-005453-4057qib7 2823 28 Alberta Alberta NNP cord-005453-4057qib7 2823 29 , , , cord-005453-4057qib7 2823 30 Canada Canada NNP cord-005453-4057qib7 2823 31 from from IN cord-005453-4057qib7 2823 32 July July NNP cord-005453-4057qib7 2823 33 2013 2013 CD cord-005453-4057qib7 2823 34 to to IN cord-005453-4057qib7 2823 35 February February NNP cord-005453-4057qib7 2823 36 2018 2018 CD cord-005453-4057qib7 2823 37 . . . cord-005453-4057qib7 2824 1 The the DT cord-005453-4057qib7 2824 2 NMA NMA NNP cord-005453-4057qib7 2824 3 regimen regimen NN cord-005453-4057qib7 2824 4 is be VBZ cord-005453-4057qib7 2824 5 illustrated illustrate VBN cord-005453-4057qib7 2824 6 in in IN cord-005453-4057qib7 2824 7 Figure Figure NNP cord-005453-4057qib7 2824 8 1 1 CD cord-005453-4057qib7 2824 9 . . . cord-005453-4057qib7 2825 1 Reported reported JJ cord-005453-4057qib7 2825 2 renal renal JJ cord-005453-4057qib7 2825 3 outcomes outcome NNS cord-005453-4057qib7 2825 4 : : : cord-005453-4057qib7 2825 5 1 1 LS cord-005453-4057qib7 2825 6 ) ) -RRB- cord-005453-4057qib7 2825 7 measured measure VBN cord-005453-4057qib7 2825 8 GFR GFR NNP cord-005453-4057qib7 2825 9 ( ( -LRB- cord-005453-4057qib7 2825 10 DTPA DTPA NNP cord-005453-4057qib7 2825 11 ) ) -RRB- cord-005453-4057qib7 2825 12 pre pre JJ cord-005453-4057qib7 2825 13 - - JJ cord-005453-4057qib7 2825 14 HSCT HSCT NNP cord-005453-4057qib7 2825 15 , , , cord-005453-4057qib7 2825 16 2 2 CD cord-005453-4057qib7 2825 17 ) ) -RRB- cord-005453-4057qib7 2825 18 AKI AKI NNP cord-005453-4057qib7 2825 19 ( ( -LRB- cord-005453-4057qib7 2825 20 KDIGO KDIGO NNP cord-005453-4057qib7 2825 21 definition definition NN cord-005453-4057qib7 2825 22 ) ) -RRB- cord-005453-4057qib7 2825 23 post post JJ cord-005453-4057qib7 2825 24 - - JJ cord-005453-4057qib7 2825 25 HSCT HSCT NNP cord-005453-4057qib7 2825 26 by by IN cord-005453-4057qib7 2825 27 reviewing review VBG cord-005453-4057qib7 2825 28 all all DT cord-005453-4057qib7 2825 29 serum serum NN cord-005453-4057qib7 2825 30 creatinine creatinine NN cord-005453-4057qib7 2825 31 levels level NNS cord-005453-4057qib7 2825 32 from from IN cord-005453-4057qib7 2825 33 pre pre JJ cord-005453-4057qib7 2825 34 - - JJ cord-005453-4057qib7 2825 35 HSCT HSCT NNP cord-005453-4057qib7 2825 36 to to IN cord-005453-4057qib7 2825 37 one one CD cord-005453-4057qib7 2825 38 month month NN cord-005453-4057qib7 2825 39 post post NN cord-005453-4057qib7 2825 40 - - JJ cord-005453-4057qib7 2825 41 HSCT HSCT NNP cord-005453-4057qib7 2825 42 , , , cord-005453-4057qib7 2826 1 3 3 LS cord-005453-4057qib7 2826 2 ) ) -RRB- cord-005453-4057qib7 2826 3 % % NN cord-005453-4057qib7 2826 4 FO FO NNP cord-005453-4057qib7 2826 5 calculated calculate VBN cord-005453-4057qib7 2826 6 : : : cord-005453-4057qib7 2826 7 ( ( -LRB- cord-005453-4057qib7 2826 8 max max NNP cord-005453-4057qib7 2826 9 post post NN cord-005453-4057qib7 2826 10 HSCT HSCT NNP cord-005453-4057qib7 2826 11 weight weight NN cord-005453-4057qib7 2827 1 -baseline -baseline : cord-005453-4057qib7 2828 1 weight)/ weight)/ NFP cord-005453-4057qib7 2829 1 baseline baseline JJ cord-005453-4057qib7 2829 2 weight weight NN cord-005453-4057qib7 2830 1 x x LS cord-005453-4057qib7 2830 2 100 100 CD cord-005453-4057qib7 2830 3 for for IN cord-005453-4057qib7 2830 4 the the DT cord-005453-4057qib7 2830 5 two two CD cord-005453-4057qib7 2830 6 first first JJ cord-005453-4057qib7 2830 7 weeks week NNS cord-005453-4057qib7 2830 8 post post JJ cord-005453-4057qib7 2830 9 - - JJ cord-005453-4057qib7 2830 10 HSCT HSCT NNP cord-005453-4057qib7 2830 11 , , , cord-005453-4057qib7 2830 12 and and CC cord-005453-4057qib7 2830 13 4 4 LS cord-005453-4057qib7 2830 14 ) ) -RRB- cord-005453-4057qib7 2830 15 estimated estimate VBN cord-005453-4057qib7 2830 16 GFR GFR NNP cord-005453-4057qib7 2830 17 ( ( -LRB- cord-005453-4057qib7 2830 18 eGFR egfr NN cord-005453-4057qib7 2830 19 ) ) -RRB- cord-005453-4057qib7 2830 20 using use VBG cord-005453-4057qib7 2830 21 the the DT cord-005453-4057qib7 2830 22 pediatric pediatric JJ cord-005453-4057qib7 2830 23 Schwartz Schwartz NNP cord-005453-4057qib7 2830 24 formula formula NN cord-005453-4057qib7 2830 25 at at IN cord-005453-4057qib7 2830 26 last last JJ cord-005453-4057qib7 2830 27 follow follow NN cord-005453-4057qib7 2830 28 - - HYPH cord-005453-4057qib7 2830 29 up up NN cord-005453-4057qib7 2830 30 post post JJ cord-005453-4057qib7 2830 31 - - JJ cord-005453-4057qib7 2830 32 HSCT HSCT NNP cord-005453-4057qib7 2830 33 , , , cord-005453-4057qib7 2830 34 CKD CKD NNP cord-005453-4057qib7 2830 35 defined define VBD cord-005453-4057qib7 2830 36 as as IN cord-005453-4057qib7 2830 37 eGFR egfr NN cord-005453-4057qib7 2830 38 < < XX cord-005453-4057qib7 2830 39 60 60 CD cord-005453-4057qib7 2830 40 mL/ mL/ NNS cord-005453-4057qib7 2831 1 min/1.73 min/1.73 NNP cord-005453-4057qib7 2831 2 m m CD cord-005453-4057qib7 2831 3 2 2 CD cord-005453-4057qib7 2831 4 , , , cord-005453-4057qib7 2831 5 mildly mildly RB cord-005453-4057qib7 2831 6 reduced reduce VBN cord-005453-4057qib7 2831 7 GFR gfr NN cord-005453-4057qib7 2831 8 : : : cord-005453-4057qib7 2832 1 60 60 CD cord-005453-4057qib7 2832 2 - - HYPH cord-005453-4057qib7 2832 3 90mL 90ml CD cord-005453-4057qib7 2833 1 /min/1.73 /min/1.73 NFP cord-005453-4057qib7 2833 2 m m NNP cord-005453-4057qib7 2833 3 2 2 CD cord-005453-4057qib7 2833 4 , , , cord-005453-4057qib7 2833 5 and and CC cord-005453-4057qib7 2833 6 hyperfiltration hyperfiltration NN cord-005453-4057qib7 2833 7 : : : cord-005453-4057qib7 2833 8 GFR GFR NNP cord-005453-4057qib7 2833 9 ≥ ≥ CD cord-005453-4057qib7 2833 10 150 150 CD cord-005453-4057qib7 2834 1 mL/ mL/ NNP cord-005453-4057qib7 2834 2 min/1.73 min/1.73 NNP cord-005453-4057qib7 2834 3 m m CD cord-005453-4057qib7 2834 4 2 2 CD cord-005453-4057qib7 2834 5 . . . cord-005453-4057qib7 2835 1 [ [ -LRB- cord-005453-4057qib7 2835 2 [ [ -LRB- cord-005453-4057qib7 2835 3 P140 P140 NNP cord-005453-4057qib7 2835 4 Image image NN cord-005453-4057qib7 2835 5 ] ] -RRB- cord-005453-4057qib7 2835 6 1 1 CD cord-005453-4057qib7 2835 7 . . . cord-005453-4057qib7 2836 1 Results result NNS cord-005453-4057qib7 2836 2 : : : cord-005453-4057qib7 2837 1 Eighteen eighteen CD cord-005453-4057qib7 2837 2 patients patient NNS cord-005453-4057qib7 2837 3 ( ( -LRB- cord-005453-4057qib7 2837 4 33 33 CD cord-005453-4057qib7 2837 5 % % NN cord-005453-4057qib7 2837 6 male male NN cord-005453-4057qib7 2837 7 , , , cord-005453-4057qib7 2837 8 3 3 CD cord-005453-4057qib7 2837 9 - - SYM cord-005453-4057qib7 2837 10 18 18 CD cord-005453-4057qib7 2837 11 years year NNS cord-005453-4057qib7 2837 12 old old JJ cord-005453-4057qib7 2837 13 at at IN cord-005453-4057qib7 2837 14 transplant transplant NN cord-005453-4057qib7 2837 15 ) ) -RRB- cord-005453-4057qib7 2837 16 were be VBD cord-005453-4057qib7 2837 17 included include VBN cord-005453-4057qib7 2837 18 . . . cord-005453-4057qib7 2838 1 Most Most JJS cord-005453-4057qib7 2838 2 common common JJ cord-005453-4057qib7 2838 3 pre pre JJ cord-005453-4057qib7 2838 4 - - JJ cord-005453-4057qib7 2838 5 morbid morbid JJ cord-005453-4057qib7 2838 6 events event NNS cord-005453-4057qib7 2838 7 : : : cord-005453-4057qib7 2838 8 vaso vaso JJ cord-005453-4057qib7 2838 9 - - HYPH cord-005453-4057qib7 2838 10 occlusive occlusive JJ cord-005453-4057qib7 2838 11 crisis crisis NN cord-005453-4057qib7 2838 12 ( ( -LRB- cord-005453-4057qib7 2838 13 n=17 n=17 NNP cord-005453-4057qib7 2838 14 ) ) -RRB- cord-005453-4057qib7 2838 15 , , , cord-005453-4057qib7 2838 16 acute acute JJ cord-005453-4057qib7 2838 17 chest chest NN cord-005453-4057qib7 2838 18 syndrome syndrome NN cord-005453-4057qib7 2838 19 ( ( -LRB- cord-005453-4057qib7 2838 20 n=8 n=8 NNP cord-005453-4057qib7 2838 21 ) ) -RRB- cord-005453-4057qib7 2838 22 , , , cord-005453-4057qib7 2838 23 splenic splenic JJ cord-005453-4057qib7 2838 24 sequestration sequestration NN cord-005453-4057qib7 2838 25 ( ( -LRB- cord-005453-4057qib7 2838 26 n=6 n=6 NNP cord-005453-4057qib7 2838 27 ) ) -RRB- cord-005453-4057qib7 2838 28 , , , cord-005453-4057qib7 2838 29 and and CC cord-005453-4057qib7 2838 30 cholelithiasis cholelithiasis NNP cord-005453-4057qib7 2838 31 ( ( -LRB- cord-005453-4057qib7 2838 32 n=4 n=4 NNP cord-005453-4057qib7 2838 33 ) ) -RRB- cord-005453-4057qib7 2838 34 . . . cord-005453-4057qib7 2839 1 Median median JJ cord-005453-4057qib7 2839 2 follow follow NN cord-005453-4057qib7 2839 3 - - HYPH cord-005453-4057qib7 2839 4 up up NN cord-005453-4057qib7 2839 5 time time NN cord-005453-4057qib7 2839 6 : : : cord-005453-4057qib7 2839 7 27 27 CD cord-005453-4057qib7 2839 8 months month NNS cord-005453-4057qib7 2839 9 ( ( -LRB- cord-005453-4057qib7 2839 10 range range NN cord-005453-4057qib7 2839 11 : : : cord-005453-4057qib7 2839 12 7 7 CD cord-005453-4057qib7 2839 13 -62 -62 NN cord-005453-4057qib7 2839 14 months month NNS cord-005453-4057qib7 2839 15 ) ) -RRB- cord-005453-4057qib7 2839 16 . . . cord-005453-4057qib7 2840 1 All all DT cord-005453-4057qib7 2840 2 patients patient NNS cord-005453-4057qib7 2840 3 engrafted engraft VBD cord-005453-4057qib7 2840 4 successfully successfully RB cord-005453-4057qib7 2840 5 with with IN cord-005453-4057qib7 2840 6 no no DT cord-005453-4057qib7 2840 7 acute acute JJ cord-005453-4057qib7 2840 8 or or CC cord-005453-4057qib7 2840 9 chronic chronic JJ cord-005453-4057qib7 2840 10 GVHD GVHD NNP cord-005453-4057qib7 2840 11 . . . cord-005453-4057qib7 2841 1 Baseline baseline JJ cord-005453-4057qib7 2841 2 measured measure VBN cord-005453-4057qib7 2841 3 GFRs gfr NNS cord-005453-4057qib7 2841 4 were be VBD cord-005453-4057qib7 2841 5 all all DT cord-005453-4057qib7 2841 6 > > XX cord-005453-4057qib7 2842 1 60 60 CD cord-005453-4057qib7 2842 2 mL ml NN cord-005453-4057qib7 2842 3 / / SYM cord-005453-4057qib7 2842 4 min/1.73 min/1.73 JJ cord-005453-4057qib7 2842 5 m m CD cord-005453-4057qib7 2842 6 2 2 CD cord-005453-4057qib7 2843 1 ( ( -LRB- cord-005453-4057qib7 2843 2 range range NN cord-005453-4057qib7 2843 3 : : : cord-005453-4057qib7 2843 4 79 79 CD cord-005453-4057qib7 2843 5 - - SYM cord-005453-4057qib7 2843 6 227 227 CD cord-005453-4057qib7 2843 7 ) ) -RRB- cord-005453-4057qib7 2843 8 with with IN cord-005453-4057qib7 2843 9 mildly mildly RB cord-005453-4057qib7 2843 10 reduced reduce VBN cord-005453-4057qib7 2843 11 GFR GFR NNP cord-005453-4057qib7 2843 12 and and CC cord-005453-4057qib7 2843 13 hyperfiltration hyperfiltration NN cord-005453-4057qib7 2843 14 seen see VBN cord-005453-4057qib7 2843 15 in in IN cord-005453-4057qib7 2843 16 one one CD cord-005453-4057qib7 2843 17 ( ( -LRB- cord-005453-4057qib7 2843 18 5.6 5.6 CD cord-005453-4057qib7 2843 19 % % NN cord-005453-4057qib7 2843 20 ) ) -RRB- cord-005453-4057qib7 2843 21 and and CC cord-005453-4057qib7 2843 22 12 12 CD cord-005453-4057qib7 2843 23 ( ( -LRB- cord-005453-4057qib7 2843 24 66.7 66.7 CD cord-005453-4057qib7 2843 25 % % NN cord-005453-4057qib7 2843 26 ) ) -RRB- cord-005453-4057qib7 2843 27 patients patient NNS cord-005453-4057qib7 2843 28 respectively respectively RB cord-005453-4057qib7 2843 29 . . . cord-005453-4057qib7 2844 1 At at IN cord-005453-4057qib7 2844 2 baseline baseline JJ cord-005453-4057qib7 2844 3 ( ( -LRB- cord-005453-4057qib7 2844 4 pre pre JJ cord-005453-4057qib7 2844 5 - - JJ cord-005453-4057qib7 2844 6 HSCT HSCT NNP cord-005453-4057qib7 2844 7 ) ) -RRB- cord-005453-4057qib7 2844 8 , , , cord-005453-4057qib7 2844 9 the the DT cord-005453-4057qib7 2844 10 only only JJ cord-005453-4057qib7 2844 11 AKI AKI NNP cord-005453-4057qib7 2844 12 event event NN cord-005453-4057qib7 2844 13 was be VBD cord-005453-4057qib7 2844 14 one one CD cord-005453-4057qib7 2844 15 transplant transplant NN cord-005453-4057qib7 2844 16 related relate VBN cord-005453-4057qib7 2844 17 AKI AKI NNP cord-005453-4057qib7 2844 18 secondary secondary JJ cord-005453-4057qib7 2844 19 to to IN cord-005453-4057qib7 2844 20 delayed delayed JJ cord-005453-4057qib7 2844 21 hemolytic hemolytic JJ cord-005453-4057qib7 2844 22 reaction reaction NN cord-005453-4057qib7 2844 23 after after IN cord-005453-4057qib7 2844 24 exchange exchange NN cord-005453-4057qib7 2844 25 transfusion transfusion NN cord-005453-4057qib7 2844 26 in in IN cord-005453-4057qib7 2844 27 preparation preparation NN cord-005453-4057qib7 2844 28 for for IN cord-005453-4057qib7 2844 29 transplant transplant NN cord-005453-4057qib7 2844 30 . . . cord-005453-4057qib7 2845 1 Post post JJ cord-005453-4057qib7 2845 2 - - JJ cord-005453-4057qib7 2845 3 HSCT HSCT NNP cord-005453-4057qib7 2845 4 , , , cord-005453-4057qib7 2845 5 there there EX cord-005453-4057qib7 2845 6 were be VBD cord-005453-4057qib7 2845 7 no no DT cord-005453-4057qib7 2845 8 AKI AKI NNP cord-005453-4057qib7 2845 9 events event NNS cord-005453-4057qib7 2845 10 . . . cord-005453-4057qib7 2846 1 Additionally additionally RB cord-005453-4057qib7 2846 2 , , , cord-005453-4057qib7 2846 3 no no DT cord-005453-4057qib7 2846 4 substantial substantial JJ cord-005453-4057qib7 2846 5 % % NN cord-005453-4057qib7 2846 6 FO fo IN cord-005453-4057qib7 2846 7 post post NN cord-005453-4057qib7 2846 8 - - JJ cord-005453-4057qib7 2846 9 HSCT HSCT NNP cord-005453-4057qib7 2846 10 was be VBD cord-005453-4057qib7 2846 11 observed observe VBN cord-005453-4057qib7 2846 12 . . . cord-005453-4057qib7 2847 1 Average average JJ cord-005453-4057qib7 2847 2 % % NN cord-005453-4057qib7 2847 3 FO FO NNP cord-005453-4057qib7 2847 4 week week NN cord-005453-4057qib7 2847 5 one one CD cord-005453-4057qib7 2847 6 post post JJ cord-005453-4057qib7 2847 7 - - JJ cord-005453-4057qib7 2847 8 HSCT hsct JJ cord-005453-4057qib7 2847 9 : : : cord-005453-4057qib7 2847 10 +0.01 +0.01 JJR cord-005453-4057qib7 2847 11 % % NN cord-005453-4057qib7 2847 12 ( ( -LRB- cord-005453-4057qib7 2847 13 Range range NN cord-005453-4057qib7 2847 14 : : : cord-005453-4057qib7 2847 15 -4.2 -4.2 CD cord-005453-4057qib7 2847 16 % % NN cord-005453-4057qib7 2847 17 -+1.0 -+1.0 NNP cord-005453-4057qib7 2847 18 % % NN cord-005453-4057qib7 2847 19 ) ) -RRB- cord-005453-4057qib7 2847 20 and and CC cord-005453-4057qib7 2847 21 week week NN cord-005453-4057qib7 2847 22 two two CD cord-005453-4057qib7 2847 23 post post JJ cord-005453-4057qib7 2847 24 - - JJ cord-005453-4057qib7 2847 25 HSCT HSCT NNP cord-005453-4057qib7 2847 26 : : : cord-005453-4057qib7 2848 1 +0.04 +0.04 NNP cord-005453-4057qib7 2848 2 % % NN cord-005453-4057qib7 2849 1 ( ( -LRB- cord-005453-4057qib7 2849 2 Range range NN cord-005453-4057qib7 2849 3 : : : cord-005453-4057qib7 2849 4 -4.24 -4.24 CD cord-005453-4057qib7 2849 5 % % NN cord-005453-4057qib7 2850 1 -+1.5 -+1.5 NNP cord-005453-4057qib7 2850 2 % % NN cord-005453-4057qib7 2850 3 ) ) -RRB- cord-005453-4057qib7 2850 4 . . . cord-005453-4057qib7 2851 1 Post post JJ cord-005453-4057qib7 2851 2 - - JJ cord-005453-4057qib7 2851 3 HSCT HSCT NNP cord-005453-4057qib7 2851 4 eGFR egfr NN cord-005453-4057qib7 2851 5 remained remain VBD cord-005453-4057qib7 2851 6 > > XX cord-005453-4057qib7 2852 1 90 90 CD cord-005453-4057qib7 2852 2 mL ml NN cord-005453-4057qib7 2852 3 / / SYM cord-005453-4057qib7 2852 4 min/1.73 min/1.73 JJ cord-005453-4057qib7 2852 5 m m CD cord-005453-4057qib7 2852 6 2 2 CD cord-005453-4057qib7 2852 7 at at IN cord-005453-4057qib7 2852 8 last last JJ cord-005453-4057qib7 2852 9 follow follow NN cord-005453-4057qib7 2852 10 - - HYPH cord-005453-4057qib7 2852 11 up up NN cord-005453-4057qib7 2852 12 in in IN cord-005453-4057qib7 2852 13 all all DT cord-005453-4057qib7 2852 14 patients patient NNS cord-005453-4057qib7 2852 15 . . . cord-005453-4057qib7 2853 1 Hyperfiltration hyperfiltration NN cord-005453-4057qib7 2853 2 was be VBD cord-005453-4057qib7 2853 3 present present JJ cord-005453-4057qib7 2853 4 in in IN cord-005453-4057qib7 2853 5 5 5 CD cord-005453-4057qib7 2853 6 ( ( -LRB- cord-005453-4057qib7 2853 7 27.8 27.8 CD cord-005453-4057qib7 2853 8 % % NN cord-005453-4057qib7 2853 9 ) ) -RRB- cord-005453-4057qib7 2853 10 of of IN cord-005453-4057qib7 2853 11 the the DT cord-005453-4057qib7 2853 12 patients patient NNS cord-005453-4057qib7 2853 13 . . . cord-005453-4057qib7 2854 1 Conclusions conclusion NNS cord-005453-4057qib7 2854 2 : : : cord-005453-4057qib7 2855 1 This this DT cord-005453-4057qib7 2855 2 is be VBZ cord-005453-4057qib7 2855 3 the the DT cord-005453-4057qib7 2855 4 first first JJ cord-005453-4057qib7 2855 5 study study NN cord-005453-4057qib7 2855 6 describing describe VBG cord-005453-4057qib7 2855 7 stable stable JJ cord-005453-4057qib7 2855 8 kidney kidney NN cord-005453-4057qib7 2855 9 function function NN cord-005453-4057qib7 2855 10 in in IN cord-005453-4057qib7 2855 11 children child NNS cord-005453-4057qib7 2855 12 with with IN cord-005453-4057qib7 2855 13 SCD SCD NNP cord-005453-4057qib7 2855 14 after after IN cord-005453-4057qib7 2855 15 the the DT cord-005453-4057qib7 2855 16 present present JJ cord-005453-4057qib7 2855 17 NMA NMA NNP cord-005453-4057qib7 2855 18 HSCT HSCT NNP cord-005453-4057qib7 2855 19 regimen regimen NN cord-005453-4057qib7 2855 20 with with IN cord-005453-4057qib7 2855 21 alemtuzumab/300 alemtuzumab/300 NNP cord-005453-4057qib7 2855 22 cGy cGy NNP cord-005453-4057qib7 2855 23 total total JJ cord-005453-4057qib7 2855 24 body body NN cord-005453-4057qib7 2855 25 irradiation irradiation NN cord-005453-4057qib7 2855 26 ( ( -LRB- cord-005453-4057qib7 2855 27 TBI TBI NNP cord-005453-4057qib7 2855 28 ) ) -RRB- cord-005453-4057qib7 2855 29 with with IN cord-005453-4057qib7 2855 30 prolonged prolong VBN cord-005453-4057qib7 2855 31 post post JJ cord-005453-4057qib7 2855 32 - - JJ cord-005453-4057qib7 2855 33 HSCT HSCT NNP cord-005453-4057qib7 2855 34 Sirolimus Sirolimus NNP cord-005453-4057qib7 2855 35 . . . cord-005453-4057qib7 2856 1 No no DT cord-005453-4057qib7 2856 2 episodes episode NNS cord-005453-4057qib7 2856 3 of of IN cord-005453-4057qib7 2856 4 AKI AKI NNP cord-005453-4057qib7 2856 5 or or CC cord-005453-4057qib7 2856 6 significant significant JJ cord-005453-4057qib7 2856 7 fluid fluid JJ cord-005453-4057qib7 2856 8 overload overload NN cord-005453-4057qib7 2856 9 were be VBD cord-005453-4057qib7 2856 10 observed observe VBN cord-005453-4057qib7 2856 11 during during IN cord-005453-4057qib7 2856 12 the the DT cord-005453-4057qib7 2856 13 first first JJ cord-005453-4057qib7 2856 14 month month NN cord-005453-4057qib7 2856 15 post post NN cord-005453-4057qib7 2856 16 - - JJ cord-005453-4057qib7 2856 17 HSCT HSCT NNP cord-005453-4057qib7 2856 18 , , , cord-005453-4057qib7 2856 19 and and CC cord-005453-4057qib7 2856 20 no no DT cord-005453-4057qib7 2856 21 patient patient NN cord-005453-4057qib7 2856 22 developed develop VBD cord-005453-4057qib7 2856 23 CKD CKD NNP cord-005453-4057qib7 2856 24 during during IN cord-005453-4057qib7 2856 25 follow follow NN cord-005453-4057qib7 2856 26 - - HYPH cord-005453-4057qib7 2856 27 up up NN cord-005453-4057qib7 2856 28 . . . cord-005453-4057qib7 2857 1 Further further JJ cord-005453-4057qib7 2857 2 prospective prospective JJ cord-005453-4057qib7 2857 3 studies study NNS cord-005453-4057qib7 2857 4 are be VBP cord-005453-4057qib7 2857 5 needed need VBN cord-005453-4057qib7 2857 6 to to TO cord-005453-4057qib7 2857 7 confirm confirm VB cord-005453-4057qib7 2857 8 our -PRON- PRP$ cord-005453-4057qib7 2857 9 findings finding NNS cord-005453-4057qib7 2857 10 and and CC cord-005453-4057qib7 2857 11 to to TO cord-005453-4057qib7 2857 12 determine determine VB cord-005453-4057qib7 2857 13 if if IN cord-005453-4057qib7 2857 14 stable stable JJ cord-005453-4057qib7 2857 15 renal renal JJ cord-005453-4057qib7 2857 16 function function NN cord-005453-4057qib7 2857 17 persists persist VBZ cord-005453-4057qib7 2857 18 during during IN cord-005453-4057qib7 2857 19 longer long JJR cord-005453-4057qib7 2857 20 - - HYPH cord-005453-4057qib7 2857 21 term term NN cord-005453-4057qib7 2857 22 followup followup NN cord-005453-4057qib7 2857 23 . . . cord-005453-4057qib7 2858 1 Disclosure disclosure NN cord-005453-4057qib7 2858 2 : : : cord-005453-4057qib7 2858 3 Nothing nothing NN cord-005453-4057qib7 2858 4 to to TO cord-005453-4057qib7 2858 5 declare declare VB cord-005453-4057qib7 2858 6 . . . cord-005453-4057qib7 2859 1 Lung lung NN cord-005453-4057qib7 2859 2 microbiota microbiota NN cord-005453-4057qib7 2859 3 in in IN cord-005453-4057qib7 2859 4 patients patient NNS cord-005453-4057qib7 2859 5 with with IN cord-005453-4057qib7 2859 6 idiopathic idiopathic JJ cord-005453-4057qib7 2859 7 pneumonia pneumonia NN cord-005453-4057qib7 2859 8 syndrome syndrome NN cord-005453-4057qib7 2859 9 ( ( -LRB- cord-005453-4057qib7 2859 10 IPS IPS NNP cord-005453-4057qib7 2859 11 ) ) -RRB- cord-005453-4057qib7 2859 12 after after IN cord-005453-4057qib7 2859 13 HCT HCT NNP cord-005453-4057qib7 2859 14 Background Background NNP cord-005453-4057qib7 2859 15 : : : cord-005453-4057qib7 2860 1 Idiopathic idiopathic JJ cord-005453-4057qib7 2860 2 pneumonia pneumonia NN cord-005453-4057qib7 2860 3 syndrome syndrome NN cord-005453-4057qib7 2860 4 ( ( -LRB- cord-005453-4057qib7 2860 5 IPS IPS NNP cord-005453-4057qib7 2860 6 ) ) -RRB- cord-005453-4057qib7 2860 7 is be VBZ cord-005453-4057qib7 2860 8 a a DT cord-005453-4057qib7 2860 9 non non JJ cord-005453-4057qib7 2860 10 - - JJ cord-005453-4057qib7 2860 11 infectious infectious JJ cord-005453-4057qib7 2860 12 pulmonary pulmonary JJ cord-005453-4057qib7 2860 13 complication complication NN cord-005453-4057qib7 2860 14 after after IN cord-005453-4057qib7 2860 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 2860 16 cell cell NN cord-005453-4057qib7 2860 17 transplantation transplantation NN cord-005453-4057qib7 2860 18 ( ( -LRB- cord-005453-4057qib7 2860 19 HCT HCT NNP cord-005453-4057qib7 2860 20 ) ) -RRB- cord-005453-4057qib7 2860 21 and and CC cord-005453-4057qib7 2860 22 the the DT cord-005453-4057qib7 2860 23 etiology etiology NN cord-005453-4057qib7 2860 24 remains remain VBZ cord-005453-4057qib7 2860 25 unknown unknown JJ cord-005453-4057qib7 2860 26 . . . cord-005453-4057qib7 2861 1 Recent recent JJ cord-005453-4057qib7 2861 2 studies study NNS cord-005453-4057qib7 2861 3 have have VBP cord-005453-4057qib7 2861 4 reported report VBN cord-005453-4057qib7 2861 5 that that IN cord-005453-4057qib7 2861 6 various various JJ cord-005453-4057qib7 2861 7 diseases disease NNS cord-005453-4057qib7 2861 8 are be VBP cord-005453-4057qib7 2861 9 associated associate VBN cord-005453-4057qib7 2861 10 with with IN cord-005453-4057qib7 2861 11 changes change NNS cord-005453-4057qib7 2861 12 of of IN cord-005453-4057qib7 2861 13 microbiota microbiota NN cord-005453-4057qib7 2861 14 . . . cord-005453-4057qib7 2862 1 The the DT cord-005453-4057qib7 2862 2 aim aim NN cord-005453-4057qib7 2862 3 of of IN cord-005453-4057qib7 2862 4 this this DT cord-005453-4057qib7 2862 5 study study NN cord-005453-4057qib7 2862 6 was be VBD cord-005453-4057qib7 2862 7 to to TO cord-005453-4057qib7 2862 8 evaluate evaluate VB cord-005453-4057qib7 2862 9 the the DT cord-005453-4057qib7 2862 10 lung lung NN cord-005453-4057qib7 2862 11 microbiota microbiota NN cord-005453-4057qib7 2862 12 in in IN cord-005453-4057qib7 2862 13 HCT HCT NNP cord-005453-4057qib7 2862 14 recipients recipient NNS cord-005453-4057qib7 2862 15 with with IN cord-005453-4057qib7 2862 16 IPS IPS NNP cord-005453-4057qib7 2862 17 and and CC cord-005453-4057qib7 2862 18 identify identify VB cord-005453-4057qib7 2862 19 microorganisms microorganism NNS cord-005453-4057qib7 2862 20 potentially potentially RB cord-005453-4057qib7 2862 21 associated associate VBN cord-005453-4057qib7 2862 22 with with IN cord-005453-4057qib7 2862 23 IPS IPS NNP cord-005453-4057qib7 2862 24 . . . cord-005453-4057qib7 2863 1 Methods method NNS cord-005453-4057qib7 2863 2 : : : cord-005453-4057qib7 2864 1 Frozen frozen JJ cord-005453-4057qib7 2864 2 bronchoalveolar bronchoalveolar JJ cord-005453-4057qib7 2864 3 lavage lavage NN cord-005453-4057qib7 2864 4 ( ( -LRB- cord-005453-4057qib7 2864 5 BAL BAL NNP cord-005453-4057qib7 2864 6 ) ) -RRB- cord-005453-4057qib7 2864 7 samples sample NNS cord-005453-4057qib7 2864 8 from from IN cord-005453-4057qib7 2864 9 HCT HCT NNP cord-005453-4057qib7 2864 10 recipients recipient NNS cord-005453-4057qib7 2864 11 with with IN cord-005453-4057qib7 2864 12 IPS IPS NNP cord-005453-4057qib7 2864 13 ( ( -LRB- cord-005453-4057qib7 2864 14 N=18 N=18 NNP cord-005453-4057qib7 2864 15 ) ) -RRB- cord-005453-4057qib7 2864 16 and and CC cord-005453-4057qib7 2864 17 research research NN cord-005453-4057qib7 2864 18 BAL bal NN cord-005453-4057qib7 2864 19 samples sample NNS cord-005453-4057qib7 2864 20 from from IN cord-005453-4057qib7 2864 21 asymptomatic asymptomatic JJ cord-005453-4057qib7 2864 22 HCT HCT NNP cord-005453-4057qib7 2864 23 recipients recipient NNS cord-005453-4057qib7 2864 24 as as IN cord-005453-4057qib7 2864 25 controls control NNS cord-005453-4057qib7 2864 26 ( ( -LRB- cord-005453-4057qib7 2864 27 N=12 N=12 NNP cord-005453-4057qib7 2864 28 ) ) -RRB- cord-005453-4057qib7 2864 29 were be VBD cord-005453-4057qib7 2864 30 retrospectively retrospectively RB cord-005453-4057qib7 2864 31 analyzed analyze VBN cord-005453-4057qib7 2864 32 . . . cord-005453-4057qib7 2865 1 All all DT cord-005453-4057qib7 2865 2 samples sample NNS cord-005453-4057qib7 2865 3 were be VBD cord-005453-4057qib7 2865 4 negative negative JJ cord-005453-4057qib7 2865 5 for for IN cord-005453-4057qib7 2865 6 common common JJ cord-005453-4057qib7 2865 7 viruses virus NNS cord-005453-4057qib7 2865 8 by by IN cord-005453-4057qib7 2865 9 quantitative quantitative JJ cord-005453-4057qib7 2865 10 PCR PCR NNP cord-005453-4057qib7 2865 11 . . . cord-005453-4057qib7 2866 1 Sequencing sequencing NN cord-005453-4057qib7 2866 2 libraries library NNS cord-005453-4057qib7 2866 3 were be VBD cord-005453-4057qib7 2866 4 made make VBN cord-005453-4057qib7 2866 5 with with IN cord-005453-4057qib7 2866 6 1ng 1ng CD cord-005453-4057qib7 2866 7 of of IN cord-005453-4057qib7 2866 8 input input NN cord-005453-4057qib7 2866 9 DNA dna NN cord-005453-4057qib7 2866 10 per per IN cord-005453-4057qib7 2866 11 sample sample NN cord-005453-4057qib7 2866 12 ( ( -LRB- cord-005453-4057qib7 2866 13 Nextera Nextera NNP cord-005453-4057qib7 2866 14 XT XT NNP cord-005453-4057qib7 2866 15 , , , cord-005453-4057qib7 2866 16 Illumina Illumina NNP cord-005453-4057qib7 2866 17 ) ) -RRB- cord-005453-4057qib7 2866 18 . . . cord-005453-4057qib7 2867 1 Samples sample NNS cord-005453-4057qib7 2867 2 were be VBD cord-005453-4057qib7 2867 3 pooled pool VBN cord-005453-4057qib7 2867 4 and and CC cord-005453-4057qib7 2867 5 sequenced sequence VBN cord-005453-4057qib7 2867 6 by by IN cord-005453-4057qib7 2867 7 HiSeq HiSeq NNP cord-005453-4057qib7 2867 8 2000 2000 CD cord-005453-4057qib7 2867 9 to to TO cord-005453-4057qib7 2867 10 obtain obtain VB cord-005453-4057qib7 2867 11 100-bp 100-bp CD cord-005453-4057qib7 2867 12 paired pair VBN cord-005453-4057qib7 2867 13 end end NN cord-005453-4057qib7 2867 14 data datum NNS cord-005453-4057qib7 2867 15 . . . cord-005453-4057qib7 2868 1 Sequence sequence NN cord-005453-4057qib7 2868 2 data datum NNS cord-005453-4057qib7 2868 3 analysis analysis NN cord-005453-4057qib7 2868 4 and and CC cord-005453-4057qib7 2868 5 read read VB cord-005453-4057qib7 2868 6 classification classification NN cord-005453-4057qib7 2868 7 were be VBD cord-005453-4057qib7 2868 8 performed perform VBN cord-005453-4057qib7 2868 9 with with IN cord-005453-4057qib7 2868 10 Sunbeam Sunbeam NNP cord-005453-4057qib7 2868 11 and and CC cord-005453-4057qib7 2868 12 the the DT cord-005453-4057qib7 2868 13 quality quality NN cord-005453-4057qib7 2868 14 control control NN cord-005453-4057qib7 2868 15 and and CC cord-005453-4057qib7 2868 16 read read VB cord-005453-4057qib7 2868 17 classification classification NN cord-005453-4057qib7 2868 18 were be VBD cord-005453-4057qib7 2868 19 performed perform VBN cord-005453-4057qib7 2868 20 using use VBG cord-005453-4057qib7 2868 21 Komplexity Komplexity NNP cord-005453-4057qib7 2868 22 and and CC cord-005453-4057qib7 2868 23 Kraken Kraken NNP cord-005453-4057qib7 2868 24 , , , cord-005453-4057qib7 2868 25 which which WDT cord-005453-4057qib7 2868 26 classifies classify VBZ cord-005453-4057qib7 2868 27 bacterial bacterial JJ cord-005453-4057qib7 2868 28 , , , cord-005453-4057qib7 2868 29 archeal archeal NN cord-005453-4057qib7 2868 30 , , , cord-005453-4057qib7 2868 31 and and CC cord-005453-4057qib7 2868 32 viral viral JJ cord-005453-4057qib7 2868 33 genomes genome NNS cord-005453-4057qib7 2868 34 . . . cord-005453-4057qib7 2869 1 We -PRON- PRP cord-005453-4057qib7 2869 2 used use VBD cord-005453-4057qib7 2869 3 sequence sequence NN cord-005453-4057qib7 2869 4 data datum NNS cord-005453-4057qib7 2869 5 of of IN cord-005453-4057qib7 2869 6 bronchoscope bronchoscope NN cord-005453-4057qib7 2869 7 prewashes prewashe NNS cord-005453-4057qib7 2869 8 from from IN cord-005453-4057qib7 2869 9 a a DT cord-005453-4057qib7 2869 10 separate separate JJ cord-005453-4057qib7 2869 11 cohort cohort NN cord-005453-4057qib7 2869 12 as as IN cord-005453-4057qib7 2869 13 controls control NNS cord-005453-4057qib7 2869 14 for for IN cord-005453-4057qib7 2869 15 environmental environmental JJ cord-005453-4057qib7 2869 16 sources source NNS cord-005453-4057qib7 2869 17 ( ( -LRB- cord-005453-4057qib7 2869 18 N=24 N=24 NNP cord-005453-4057qib7 2869 19 ) ) -RRB- cord-005453-4057qib7 2869 20 . . . cord-005453-4057qib7 2870 1 Bray Bray NNP cord-005453-4057qib7 2870 2 - - HYPH cord-005453-4057qib7 2870 3 Curtiss Curtiss NNP cord-005453-4057qib7 2870 4 dissimilarity dissimilarity NN cord-005453-4057qib7 2870 5 among among IN cord-005453-4057qib7 2870 6 samples sample NNS cord-005453-4057qib7 2870 7 was be VBD cord-005453-4057qib7 2870 8 calculated calculate VBN cord-005453-4057qib7 2870 9 using use VBG cord-005453-4057qib7 2870 10 the the DT cord-005453-4057qib7 2870 11 Vegan Vegan NNP cord-005453-4057qib7 2870 12 R r NN cord-005453-4057qib7 2870 13 packages package NNS cord-005453-4057qib7 2870 14 . . . cord-005453-4057qib7 2871 1 PERMANOVA PERMANOVA NNP cord-005453-4057qib7 2871 2 and and CC cord-005453-4057qib7 2871 3 a a DT cord-005453-4057qib7 2871 4 two two CD cord-005453-4057qib7 2871 5 - - HYPH cord-005453-4057qib7 2871 6 sided sided JJ cord-005453-4057qib7 2871 7 Wilcoxon Wilcoxon NNP cord-005453-4057qib7 2871 8 rank rank NN cord-005453-4057qib7 2871 9 sum sum NN cord-005453-4057qib7 2871 10 test test NN cord-005453-4057qib7 2871 11 were be VBD cord-005453-4057qib7 2871 12 used use VBN cord-005453-4057qib7 2871 13 to to TO cord-005453-4057qib7 2871 14 compare compare VB cord-005453-4057qib7 2871 15 between between IN cord-005453-4057qib7 2871 16 the the DT cord-005453-4057qib7 2871 17 study study NN cord-005453-4057qib7 2871 18 groups group NNS cord-005453-4057qib7 2871 19 . . . cord-005453-4057qib7 2872 1 Results result NNS cord-005453-4057qib7 2872 2 : : : cord-005453-4057qib7 2873 1 BAL bal NN cord-005453-4057qib7 2873 2 samples sample NNS cord-005453-4057qib7 2873 3 started start VBD cord-005453-4057qib7 2873 4 at at IN cord-005453-4057qib7 2873 5 a a DT cord-005453-4057qib7 2873 6 median median NN cord-005453-4057qib7 2873 7 of of IN cord-005453-4057qib7 2873 8 22x10 22x10 CD cord-005453-4057qib7 2873 9 6 6 CD cord-005453-4057qib7 2873 10 raw raw JJ cord-005453-4057qib7 2873 11 read read NN cord-005453-4057qib7 2873 12 pairs pair NNS cord-005453-4057qib7 2873 13 per per IN cord-005453-4057qib7 2873 14 sample sample NN cord-005453-4057qib7 2873 15 and and CC cord-005453-4057qib7 2873 16 reduced reduce VBN cord-005453-4057qib7 2873 17 to to IN cord-005453-4057qib7 2873 18 21x10 21x10 CD cord-005453-4057qib7 2873 19 3 3 CD cord-005453-4057qib7 2873 20 reads read VBZ cord-005453-4057qib7 2873 21 assignable assignable JJ cord-005453-4057qib7 2873 22 to to IN cord-005453-4057qib7 2873 23 microbial microbial JJ cord-005453-4057qib7 2873 24 taxa taxon NNS cord-005453-4057qib7 2873 25 following follow VBG cord-005453-4057qib7 2873 26 quality quality NN cord-005453-4057qib7 2873 27 control control NN cord-005453-4057qib7 2873 28 . . . cord-005453-4057qib7 2874 1 The the DT cord-005453-4057qib7 2874 2 bacterial bacterial JJ cord-005453-4057qib7 2874 3 phyla phylum NNS cord-005453-4057qib7 2875 1 Proteobacteria Proteobacteria NNP cord-005453-4057qib7 2875 2 and and CC cord-005453-4057qib7 2875 3 Firmicutes Firmicutes NNPS cord-005453-4057qib7 2875 4 were be VBD cord-005453-4057qib7 2875 5 most most RBS cord-005453-4057qib7 2875 6 abundant abundant JJ cord-005453-4057qib7 2875 7 followed follow VBN cord-005453-4057qib7 2875 8 by by IN cord-005453-4057qib7 2875 9 Bacteroidetes Bacteroidetes NNPS cord-005453-4057qib7 2875 10 and and CC cord-005453-4057qib7 2875 11 Actinobacteria Actinobacteria NNP cord-005453-4057qib7 2875 12 in in IN cord-005453-4057qib7 2875 13 both both DT cord-005453-4057qib7 2875 14 BAL bal NN cord-005453-4057qib7 2875 15 and and CC cord-005453-4057qib7 2875 16 bronchoscope bronchoscope NN cord-005453-4057qib7 2875 17 prewash prewash NN cord-005453-4057qib7 2875 18 samples sample NNS cord-005453-4057qib7 2875 19 . . . cord-005453-4057qib7 2876 1 Separation separation NN cord-005453-4057qib7 2876 2 of of IN cord-005453-4057qib7 2876 3 BAL bal NN cord-005453-4057qib7 2876 4 and and CC cord-005453-4057qib7 2876 5 prewash prewash NN cord-005453-4057qib7 2876 6 microbiota microbiota NN cord-005453-4057qib7 2876 7 using use VBG cord-005453-4057qib7 2876 8 Bray Bray NNP cord-005453-4057qib7 2876 9 - - HYPH cord-005453-4057qib7 2876 10 Curtiss Curtiss NNP cord-005453-4057qib7 2876 11 dissimilarity dissimilarity NN cord-005453-4057qib7 2876 12 plots plot NNS cord-005453-4057qib7 2876 13 showed show VBD cord-005453-4057qib7 2876 14 that that IN cord-005453-4057qib7 2876 15 BAL bal NN cord-005453-4057qib7 2876 16 samples sample NNS cord-005453-4057qib7 2876 17 were be VBD cord-005453-4057qib7 2876 18 distinguished distinguish VBN cord-005453-4057qib7 2876 19 by by IN cord-005453-4057qib7 2876 20 sequences sequence NNS cord-005453-4057qib7 2876 21 assigned assign VBN cord-005453-4057qib7 2876 22 to to IN cord-005453-4057qib7 2876 23 Staphylococcus Staphylococcus NNP cord-005453-4057qib7 2876 24 , , , cord-005453-4057qib7 2876 25 Acidovorax Acidovorax NNP cord-005453-4057qib7 2876 26 , , , cord-005453-4057qib7 2876 27 and and CC cord-005453-4057qib7 2876 28 Bradyrhizobium Bradyrhizobium NNP cord-005453-4057qib7 2876 29 species specie NNS cord-005453-4057qib7 2876 30 , , , cord-005453-4057qib7 2876 31 while while IN cord-005453-4057qib7 2876 32 prewash prewash NN cord-005453-4057qib7 2876 33 samples sample NNS cord-005453-4057qib7 2876 34 were be VBD cord-005453-4057qib7 2876 35 distinguished distinguish VBN cord-005453-4057qib7 2876 36 mostly mostly RB cord-005453-4057qib7 2876 37 by by IN cord-005453-4057qib7 2876 38 Pseudomonas Pseudomonas NNP cord-005453-4057qib7 2876 39 and and CC cord-005453-4057qib7 2876 40 Elizabethkingia Elizabethkingia NNP cord-005453-4057qib7 2876 41 species specie NNS cord-005453-4057qib7 2876 42 , , , cord-005453-4057qib7 2876 43 consistent consistent JJ cord-005453-4057qib7 2876 44 with with IN cord-005453-4057qib7 2876 45 environmental environmental JJ cord-005453-4057qib7 2876 46 sources source NNS cord-005453-4057qib7 2876 47 ( ( -LRB- cord-005453-4057qib7 2876 48 Figure figure NN cord-005453-4057qib7 2876 49 ) ) -RRB- cord-005453-4057qib7 2876 50 . . . cord-005453-4057qib7 2877 1 Within within IN cord-005453-4057qib7 2877 2 BAL bal NN cord-005453-4057qib7 2877 3 samples sample NNS cord-005453-4057qib7 2877 4 , , , cord-005453-4057qib7 2877 5 Staphylococcus Staphylococcus NNP cord-005453-4057qib7 2877 6 species specie NNS cord-005453-4057qib7 2877 7 were be VBD cord-005453-4057qib7 2877 8 the the DT cord-005453-4057qib7 2877 9 main main JJ cord-005453-4057qib7 2877 10 drivers driver NNS cord-005453-4057qib7 2877 11 of of IN cord-005453-4057qib7 2877 12 separation separation NN cord-005453-4057qib7 2877 13 between between IN cord-005453-4057qib7 2877 14 IPS IPS NNP cord-005453-4057qib7 2877 15 cases case NNS cord-005453-4057qib7 2877 16 and and CC cord-005453-4057qib7 2877 17 the the DT cord-005453-4057qib7 2877 18 controls control NNS cord-005453-4057qib7 2877 19 ( ( -LRB- cord-005453-4057qib7 2877 20 p=0.002 p=0.002 NNP cord-005453-4057qib7 2877 21 , , , cord-005453-4057qib7 2877 22 PERMANOVA PERMANOVA NNP cord-005453-4057qib7 2877 23 , , , cord-005453-4057qib7 2877 24 Figure figure NN cord-005453-4057qib7 2877 25 ) ) -RRB- cord-005453-4057qib7 2877 26 . . . cord-005453-4057qib7 2878 1 Consistent consistent JJ cord-005453-4057qib7 2878 2 with with IN cord-005453-4057qib7 2878 3 this this DT cord-005453-4057qib7 2878 4 , , , cord-005453-4057qib7 2878 5 a a DT cord-005453-4057qib7 2878 6 linear linear JJ cord-005453-4057qib7 2878 7 discriminant discriminant JJ cord-005453-4057qib7 2878 8 analysis analysis NN cord-005453-4057qib7 2878 9 to to TO cord-005453-4057qib7 2878 10 identify identify VB cord-005453-4057qib7 2878 11 taxa taxon NNS cord-005453-4057qib7 2878 12 best well RBS cord-005453-4057qib7 2878 13 distinguishing distinguishing JJ cord-005453-4057qib7 2878 14 cases case NNS cord-005453-4057qib7 2878 15 and and CC cord-005453-4057qib7 2878 16 controls control NNS cord-005453-4057qib7 2878 17 identified identify VBD cord-005453-4057qib7 2878 18 Staphylococcus Staphylococcus NNP cord-005453-4057qib7 2878 19 , , , cord-005453-4057qib7 2878 20 especially especially RB cord-005453-4057qib7 2878 21 S. S. NNP cord-005453-4057qib7 2878 22 epidermidis epidermidi NNS cord-005453-4057qib7 2878 23 , , , cord-005453-4057qib7 2878 24 in in IN cord-005453-4057qib7 2878 25 IPS IPS NNP cord-005453-4057qib7 2878 26 cases case NNS cord-005453-4057qib7 2878 27 with with IN cord-005453-4057qib7 2878 28 Lactobacillus lactobacillus NN cord-005453-4057qib7 2878 29 and and CC cord-005453-4057qib7 2878 30 Streptococcus Streptococcus NNP cord-005453-4057qib7 2878 31 species specie NNS cord-005453-4057qib7 2878 32 in in IN cord-005453-4057qib7 2878 33 controls control NNS cord-005453-4057qib7 2878 34 . . . cord-005453-4057qib7 2879 1 We -PRON- PRP cord-005453-4057qib7 2879 2 then then RB cord-005453-4057qib7 2879 3 compared compare VBD cord-005453-4057qib7 2879 4 relative relative JJ cord-005453-4057qib7 2879 5 abundances abundance NNS cord-005453-4057qib7 2879 6 of of IN cord-005453-4057qib7 2879 7 S. S. NNP cord-005453-4057qib7 2879 8 epidermidis epidermidi NNS cord-005453-4057qib7 2879 9 between between IN cord-005453-4057qib7 2879 10 all all DT cord-005453-4057qib7 2879 11 study study NN cord-005453-4057qib7 2879 12 groups group NNS cord-005453-4057qib7 2879 13 . . . cord-005453-4057qib7 2880 1 IPS IPS NNP cord-005453-4057qib7 2880 2 case case NN cord-005453-4057qib7 2880 3 samples sample NNS cord-005453-4057qib7 2880 4 were be VBD cord-005453-4057qib7 2880 5 significantly significantly RB cord-005453-4057qib7 2880 6 enriched enrich VBN cord-005453-4057qib7 2880 7 in in IN cord-005453-4057qib7 2880 8 S. S. NNP cord-005453-4057qib7 2880 9 epidermidis epidermidi NNS cord-005453-4057qib7 2880 10 compared compare VBN cord-005453-4057qib7 2880 11 to to TO cord-005453-4057qib7 2880 12 control control NN cord-005453-4057qib7 2880 13 ( ( -LRB- cord-005453-4057qib7 2880 14 p p NN cord-005453-4057qib7 2880 15 < < XX cord-005453-4057qib7 2880 16 0.001 0.001 CD cord-005453-4057qib7 2880 17 , , , cord-005453-4057qib7 2880 18 two two CD cord-005453-4057qib7 2880 19 - - HYPH cord-005453-4057qib7 2880 20 sided sided JJ cord-005453-4057qib7 2880 21 Wilcoxon Wilcoxon NNP cord-005453-4057qib7 2880 22 rank rank NN cord-005453-4057qib7 2880 23 sum sum NN cord-005453-4057qib7 2880 24 test test NN cord-005453-4057qib7 2880 25 ) ) -RRB- cord-005453-4057qib7 2880 26 and and CC cord-005453-4057qib7 2880 27 prewash prewash VB cord-005453-4057qib7 2880 28 samples sample NNS cord-005453-4057qib7 2880 29 ( ( -LRB- cord-005453-4057qib7 2880 30 p p NN cord-005453-4057qib7 2880 31 < < XX cord-005453-4057qib7 2880 32 0.001 0.001 CD cord-005453-4057qib7 2880 33 ) ) -RRB- cord-005453-4057qib7 2880 34 . . . cord-005453-4057qib7 2881 1 Viruses virus NNS cord-005453-4057qib7 2881 2 were be VBD cord-005453-4057qib7 2881 3 classified classify VBN cord-005453-4057qib7 2881 4 by by IN cord-005453-4057qib7 2881 5 category category NN cord-005453-4057qib7 2881 6 as as IN cord-005453-4057qib7 2881 7 human human JJ cord-005453-4057qib7 2881 8 pathogens pathogen NNS cord-005453-4057qib7 2881 9 , , , cord-005453-4057qib7 2881 10 non non JJ cord-005453-4057qib7 2881 11 - - JJ cord-005453-4057qib7 2881 12 human human JJ cord-005453-4057qib7 2881 13 pathogens pathogen NNS cord-005453-4057qib7 2881 14 , , , cord-005453-4057qib7 2881 15 and and CC cord-005453-4057qib7 2881 16 bacteriophages bacteriophage NNS cord-005453-4057qib7 2881 17 . . . cord-005453-4057qib7 2882 1 Torque Torque NNP cord-005453-4057qib7 2882 2 teno teno NNP cord-005453-4057qib7 2882 3 viruses virus NNS cord-005453-4057qib7 2882 4 ( ( -LRB- cord-005453-4057qib7 2882 5 TTV TTV NNP cord-005453-4057qib7 2882 6 ) ) -RRB- cord-005453-4057qib7 2882 7 was be VBD cord-005453-4057qib7 2882 8 the the DT cord-005453-4057qib7 2882 9 most most RBS cord-005453-4057qib7 2882 10 commonly commonly RB cord-005453-4057qib7 2882 11 detected detect VBN cord-005453-4057qib7 2882 12 virus virus NN cord-005453-4057qib7 2882 13 among among IN cord-005453-4057qib7 2882 14 viruses virus NNS cord-005453-4057qib7 2882 15 that that WDT cord-005453-4057qib7 2882 16 replicate replicate VBP cord-005453-4057qib7 2882 17 on on IN cord-005453-4057qib7 2882 18 human human JJ cord-005453-4057qib7 2882 19 cells cell NNS cord-005453-4057qib7 2882 20 , , , cord-005453-4057qib7 2882 21 and and CC cord-005453-4057qib7 2882 22 there there EX cord-005453-4057qib7 2882 23 was be VBD cord-005453-4057qib7 2882 24 a a DT cord-005453-4057qib7 2882 25 trend trend NN cord-005453-4057qib7 2882 26 towards towards IN cord-005453-4057qib7 2882 27 higher high JJR cord-005453-4057qib7 2882 28 abundance abundance NN cord-005453-4057qib7 2882 29 in in IN cord-005453-4057qib7 2882 30 IPS ips NN cord-005453-4057qib7 2882 31 case case NN cord-005453-4057qib7 2882 32 samples sample NNS cord-005453-4057qib7 2882 33 than than IN cord-005453-4057qib7 2882 34 controls control NNS cord-005453-4057qib7 2882 35 . . . cord-005453-4057qib7 2883 1 Conclusions conclusion NNS cord-005453-4057qib7 2883 2 : : : cord-005453-4057qib7 2884 1 Lung lung NN cord-005453-4057qib7 2884 2 microbial microbial JJ cord-005453-4057qib7 2884 3 sequences sequence NNS cord-005453-4057qib7 2884 4 in in IN cord-005453-4057qib7 2884 5 HCT HCT NNP cord-005453-4057qib7 2884 6 recipients recipient NNS cord-005453-4057qib7 2884 7 predominantly predominantly RB cord-005453-4057qib7 2884 8 consisted consist VBD cord-005453-4057qib7 2884 9 of of IN cord-005453-4057qib7 2884 10 Proteobacteria Proteobacteria NNP cord-005453-4057qib7 2884 11 and and CC cord-005453-4057qib7 2884 12 Firmicutes Firmicutes NNPS cord-005453-4057qib7 2884 13 , , , cord-005453-4057qib7 2884 14 and and CC cord-005453-4057qib7 2884 15 had have VBD cord-005453-4057qib7 2884 16 considerable considerable JJ cord-005453-4057qib7 2884 17 overlap overlap NN cord-005453-4057qib7 2884 18 with with IN cord-005453-4057qib7 2884 19 environmental environmental JJ cord-005453-4057qib7 2884 20 background background NN cord-005453-4057qib7 2884 21 . . . cord-005453-4057qib7 2885 1 Patients patient NNS cord-005453-4057qib7 2885 2 with with IN cord-005453-4057qib7 2885 3 IPS IPS NNP cord-005453-4057qib7 2885 4 had have VBD cord-005453-4057qib7 2885 5 significantly significantly RB cord-005453-4057qib7 2885 6 more more JJR cord-005453-4057qib7 2885 7 Staphylococcus staphylococcus NN cord-005453-4057qib7 2885 8 sequences sequence NNS cord-005453-4057qib7 2885 9 detected detect VBD cord-005453-4057qib7 2885 10 than than IN cord-005453-4057qib7 2885 11 asymptomatic asymptomatic JJ cord-005453-4057qib7 2885 12 HCT HCT NNP cord-005453-4057qib7 2885 13 patients patient NNS cord-005453-4057qib7 2885 14 . . . cord-005453-4057qib7 2886 1 These these DT cord-005453-4057qib7 2886 2 results result NNS cord-005453-4057qib7 2886 3 suggest suggest VBP cord-005453-4057qib7 2886 4 that that IN cord-005453-4057qib7 2886 5 patients patient NNS cord-005453-4057qib7 2886 6 with with IN cord-005453-4057qib7 2886 7 acute acute JJ cord-005453-4057qib7 2886 8 lung lung NN cord-005453-4057qib7 2886 9 injury injury NN cord-005453-4057qib7 2886 10 post post JJ cord-005453-4057qib7 2886 11 - - JJ cord-005453-4057qib7 2886 12 HCT HCT NNP cord-005453-4057qib7 2886 13 show show VBP cord-005453-4057qib7 2886 14 distinct distinct JJ cord-005453-4057qib7 2886 15 patterns pattern NNS cord-005453-4057qib7 2886 16 of of IN cord-005453-4057qib7 2886 17 lung lung NN cord-005453-4057qib7 2886 18 microbiota microbiota NN cord-005453-4057qib7 2886 19 , , , cord-005453-4057qib7 2886 20 although although IN cord-005453-4057qib7 2886 21 heterogeneity heterogeneity NN cord-005453-4057qib7 2886 22 of of IN cord-005453-4057qib7 2886 23 sample sample NN cord-005453-4057qib7 2886 24 collection collection NN cord-005453-4057qib7 2886 25 and and CC cord-005453-4057qib7 2886 26 processing processing NN cord-005453-4057qib7 2886 27 can can MD cord-005453-4057qib7 2886 28 not not RB cord-005453-4057qib7 2886 29 be be VB cord-005453-4057qib7 2886 30 excluded exclude VBN cord-005453-4057qib7 2886 31 and and CC cord-005453-4057qib7 2886 32 no no DT cord-005453-4057qib7 2886 33 singular singular JJ cord-005453-4057qib7 2886 34 organism organism NN cord-005453-4057qib7 2886 35 was be VBD cord-005453-4057qib7 2886 36 uniquely uniquely RB cord-005453-4057qib7 2886 37 associated associate VBN cord-005453-4057qib7 2886 38 with with IN cord-005453-4057qib7 2886 39 IPS IPS NNP cord-005453-4057qib7 2886 40 . . . cord-005453-4057qib7 2887 1 A a DT cord-005453-4057qib7 2887 2 prospective prospective JJ cord-005453-4057qib7 2887 3 study study NN cord-005453-4057qib7 2887 4 is be VBZ cord-005453-4057qib7 2887 5 required require VBN cord-005453-4057qib7 2887 6 to to TO cord-005453-4057qib7 2887 7 confirm confirm VB cord-005453-4057qib7 2887 8 these these DT cord-005453-4057qib7 2887 9 findings finding NNS cord-005453-4057qib7 2887 10 and and CC cord-005453-4057qib7 2887 11 define define VB cord-005453-4057qib7 2887 12 the the DT cord-005453-4057qib7 2887 13 clinical clinical JJ cord-005453-4057qib7 2887 14 significance significance NN cord-005453-4057qib7 2887 15 of of IN cord-005453-4057qib7 2887 16 differences difference NNS cord-005453-4057qib7 2887 17 in in IN cord-005453-4057qib7 2887 18 abundance abundance NN cord-005453-4057qib7 2887 19 patterns pattern NNS cord-005453-4057qib7 2887 20 . . . cord-005453-4057qib7 2888 1 Disclosure disclosure NN cord-005453-4057qib7 2888 2 : : : cord-005453-4057qib7 2888 3 Nothing nothing NN cord-005453-4057qib7 2888 4 to to TO cord-005453-4057qib7 2888 5 declare declare VB cord-005453-4057qib7 2888 6 P142 P142 NNP cord-005453-4057qib7 2888 7 Abstract Abstract NNP cord-005453-4057qib7 2888 8 withdrawn withdraw VBN cord-005453-4057qib7 2888 9 . . . cord-005453-4057qib7 2889 1 Romiplostim Romiplostim NNP cord-005453-4057qib7 2889 2 for for IN cord-005453-4057qib7 2889 3 the the DT cord-005453-4057qib7 2889 4 treatment treatment NN cord-005453-4057qib7 2889 5 of of IN cord-005453-4057qib7 2889 6 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2889 7 after after IN cord-005453-4057qib7 2889 8 allogeneic allogeneic NN cord-005453-4057qib7 2889 9 stem stem NN cord-005453-4057qib7 2889 10 cell cell NN cord-005453-4057qib7 2889 11 transplantation transplantation NN cord-005453-4057qib7 2889 12 Background background NN cord-005453-4057qib7 2889 13 : : : cord-005453-4057qib7 2890 1 Thrombocytopenia Thrombocytopenia NNP cord-005453-4057qib7 2890 2 is be VBZ cord-005453-4057qib7 2890 3 a a DT cord-005453-4057qib7 2890 4 common common JJ cord-005453-4057qib7 2890 5 complication complication NN cord-005453-4057qib7 2890 6 after after IN cord-005453-4057qib7 2890 7 allogeneic allogeneic NN cord-005453-4057qib7 2890 8 stem stem NN cord-005453-4057qib7 2890 9 cell cell NN cord-005453-4057qib7 2890 10 transplantation transplantation NN cord-005453-4057qib7 2890 11 ( ( -LRB- cord-005453-4057qib7 2890 12 allo allo NN cord-005453-4057qib7 2890 13 - - HYPH cord-005453-4057qib7 2890 14 HCT HCT NNP cord-005453-4057qib7 2890 15 ) ) -RRB- cord-005453-4057qib7 2890 16 . . . cord-005453-4057qib7 2891 1 with with IN cord-005453-4057qib7 2891 2 variable variable JJ cord-005453-4057qib7 2891 3 possible possible JJ cord-005453-4057qib7 2891 4 causes cause NNS cord-005453-4057qib7 2891 5 , , , cord-005453-4057qib7 2891 6 such such JJ cord-005453-4057qib7 2891 7 as as IN cord-005453-4057qib7 2891 8 drug drug NN cord-005453-4057qib7 2891 9 side side NN cord-005453-4057qib7 2891 10 effects effect NNS cord-005453-4057qib7 2891 11 , , , cord-005453-4057qib7 2891 12 infections infection NNS cord-005453-4057qib7 2891 13 , , , cord-005453-4057qib7 2891 14 poor poor JJ cord-005453-4057qib7 2891 15 graft graft NN cord-005453-4057qib7 2891 16 function function NN cord-005453-4057qib7 2891 17 , , , cord-005453-4057qib7 2891 18 Graft Graft NNP cord-005453-4057qib7 2891 19 vs vs IN cord-005453-4057qib7 2891 20 Host Host NNP cord-005453-4057qib7 2891 21 disease disease NN cord-005453-4057qib7 2891 22 ( ( -LRB- cord-005453-4057qib7 2891 23 GvHD GvHD NNP cord-005453-4057qib7 2891 24 ) ) -RRB- cord-005453-4057qib7 2891 25 and and CC cord-005453-4057qib7 2891 26 immune immune JJ cord-005453-4057qib7 2891 27 mediated mediate VBN cord-005453-4057qib7 2891 28 . . . cord-005453-4057qib7 2892 1 The the DT cord-005453-4057qib7 2892 2 purpose purpose NN cord-005453-4057qib7 2892 3 of of IN cord-005453-4057qib7 2892 4 this this DT cord-005453-4057qib7 2892 5 study study NN cord-005453-4057qib7 2892 6 was be VBD cord-005453-4057qib7 2892 7 to to TO cord-005453-4057qib7 2892 8 evaluate evaluate VB cord-005453-4057qib7 2892 9 the the DT cord-005453-4057qib7 2892 10 efficacy efficacy NN cord-005453-4057qib7 2892 11 of of IN cord-005453-4057qib7 2892 12 romiplostim romiplostim NNP cord-005453-4057qib7 2892 13 , , , cord-005453-4057qib7 2892 14 a a DT cord-005453-4057qib7 2892 15 thrombopoietin thrombopoietin NNP cord-005453-4057qib7 2892 16 receptor receptor NN cord-005453-4057qib7 2892 17 agonist agonist NN cord-005453-4057qib7 2892 18 , , , cord-005453-4057qib7 2892 19 in in IN cord-005453-4057qib7 2892 20 patients patient NNS cord-005453-4057qib7 2892 21 with with IN cord-005453-4057qib7 2892 22 prolonged prolonged JJ cord-005453-4057qib7 2892 23 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2892 24 with with IN cord-005453-4057qib7 2892 25 no no DT cord-005453-4057qib7 2892 26 obvious obvious JJ cord-005453-4057qib7 2892 27 cause cause NN cord-005453-4057qib7 2892 28 after after IN cord-005453-4057qib7 2892 29 allogeneic allogeneic NN cord-005453-4057qib7 2892 30 transplantation transplantation NN cord-005453-4057qib7 2892 31 . . . cord-005453-4057qib7 2893 1 Methods method NNS cord-005453-4057qib7 2893 2 : : : cord-005453-4057qib7 2893 3 Retrospective retrospective JJ cord-005453-4057qib7 2893 4 analysis analysis NN cord-005453-4057qib7 2893 5 of of IN cord-005453-4057qib7 2893 6 allo allo NN cord-005453-4057qib7 2893 7 - - HYPH cord-005453-4057qib7 2893 8 HCT hct NN cord-005453-4057qib7 2893 9 patients patient NNS cord-005453-4057qib7 2893 10 who who WP cord-005453-4057qib7 2893 11 received receive VBD cord-005453-4057qib7 2893 12 romiplostim romiplostim NNS cord-005453-4057qib7 2893 13 at at IN cord-005453-4057qib7 2893 14 a a DT cord-005453-4057qib7 2893 15 single single JJ cord-005453-4057qib7 2893 16 BMT BMT NNP cord-005453-4057qib7 2893 17 Unit Unit NNP cord-005453-4057qib7 2893 18 between between IN cord-005453-4057qib7 2893 19 November November NNP cord-005453-4057qib7 2893 20 2015 2015 CD cord-005453-4057qib7 2893 21 and and CC cord-005453-4057qib7 2893 22 November November NNP cord-005453-4057qib7 2893 23 2018 2018 CD cord-005453-4057qib7 2893 24 . . . cord-005453-4057qib7 2894 1 Romiplostim Romiplostim NNP cord-005453-4057qib7 2894 2 was be VBD cord-005453-4057qib7 2894 3 given give VBN cord-005453-4057qib7 2894 4 because because IN cord-005453-4057qib7 2894 5 of of IN cord-005453-4057qib7 2894 6 prolonged prolong VBN cord-005453-4057qib7 2894 7 ( ( -LRB- cord-005453-4057qib7 2894 8 > > NFP cord-005453-4057qib7 2894 9 3 3 CD cord-005453-4057qib7 2894 10 weeks week NNS cord-005453-4057qib7 2894 11 ) ) -RRB- cord-005453-4057qib7 2894 12 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2894 13 ( ( -LRB- cord-005453-4057qib7 2895 1 < < XX cord-005453-4057qib7 2895 2 60,000 60,000 CD cord-005453-4057qib7 2895 3 μL μL . cord-005453-4057qib7 2895 4 ) ) -RRB- cord-005453-4057qib7 2896 1 that that DT cord-005453-4057qib7 2896 2 could could MD cord-005453-4057qib7 2896 3 n't not RB cord-005453-4057qib7 2896 4 be be VB cord-005453-4057qib7 2896 5 explained explain VBN cord-005453-4057qib7 2896 6 by by IN cord-005453-4057qib7 2896 7 obvious obvious JJ cord-005453-4057qib7 2896 8 causes cause NNS cord-005453-4057qib7 2896 9 such such JJ cord-005453-4057qib7 2896 10 as as IN cord-005453-4057qib7 2896 11 administration administration NN cord-005453-4057qib7 2896 12 of of IN cord-005453-4057qib7 2896 13 drugs drug NNS cord-005453-4057qib7 2896 14 ( ( -LRB- cord-005453-4057qib7 2896 15 antibiotics antibiotic NNS cord-005453-4057qib7 2896 16 / / SYM cord-005453-4057qib7 2896 17 antivirals antiviral NNS cord-005453-4057qib7 2896 18 ) ) -RRB- cord-005453-4057qib7 2896 19 , , , cord-005453-4057qib7 2896 20 infection infection NN cord-005453-4057qib7 2896 21 or or CC cord-005453-4057qib7 2896 22 GvHD gvhd NN cord-005453-4057qib7 2896 23 . . . cord-005453-4057qib7 2897 1 All all DT cord-005453-4057qib7 2897 2 patients patient NNS cord-005453-4057qib7 2897 3 were be VBD cord-005453-4057qib7 2897 4 in in IN cord-005453-4057qib7 2897 5 complete complete JJ cord-005453-4057qib7 2897 6 remission remission NN cord-005453-4057qib7 2897 7 and and CC cord-005453-4057qib7 2897 8 had have VBD cord-005453-4057qib7 2897 9 complete complete JJ cord-005453-4057qib7 2897 10 chimerism chimerism NN cord-005453-4057qib7 2897 11 . . . cord-005453-4057qib7 2898 1 Response response NN cord-005453-4057qib7 2898 2 to to IN cord-005453-4057qib7 2898 3 romiplostim romiplostim NNP cord-005453-4057qib7 2898 4 treatment treatment NN cord-005453-4057qib7 2898 5 was be VBD cord-005453-4057qib7 2898 6 considered consider VBN cord-005453-4057qib7 2898 7 transfusion transfusion NN cord-005453-4057qib7 2898 8 independence independence NN cord-005453-4057qib7 2898 9 or or CC cord-005453-4057qib7 2899 1 PLT>80.000 PLT>80.000 NNP cord-005453-4057qib7 2899 2 / / SYM cord-005453-4057qib7 2899 3 μL. μl. JJ cord-005453-4057qib7 2899 4 Results result NNS cord-005453-4057qib7 2899 5 : : : cord-005453-4057qib7 2900 1 In in IN cord-005453-4057qib7 2900 2 total total JJ cord-005453-4057qib7 2900 3 , , , cord-005453-4057qib7 2900 4 19 19 CD cord-005453-4057qib7 2900 5 patients patient NNS cord-005453-4057qib7 2900 6 ( ( -LRB- cord-005453-4057qib7 2900 7 median median NN cord-005453-4057qib7 2900 8 45 45 CD cord-005453-4057qib7 2900 9 years year NNS cord-005453-4057qib7 2900 10 , , , cord-005453-4057qib7 2900 11 19 19 CD cord-005453-4057qib7 2900 12 - - SYM cord-005453-4057qib7 2900 13 67 67 CD cord-005453-4057qib7 2900 14 ) ) -RRB- cord-005453-4057qib7 2900 15 received receive VBD cord-005453-4057qib7 2900 16 romiplostim romiplostim NNS cord-005453-4057qib7 2900 17 . . . cord-005453-4057qib7 2901 1 Patients patient NNS cord-005453-4057qib7 2901 2 ( ( -LRB- cord-005453-4057qib7 2901 3 10 10 CD cord-005453-4057qib7 2901 4 male male NN cord-005453-4057qib7 2901 5 , , , cord-005453-4057qib7 2901 6 9 9 CD cord-005453-4057qib7 2901 7 females female NNS cord-005453-4057qib7 2901 8 ) ) -RRB- cord-005453-4057qib7 2901 9 had have VBD cord-005453-4057qib7 2901 10 AML AML NNP cord-005453-4057qib7 2901 11 ( ( -LRB- cord-005453-4057qib7 2901 12 10 10 CD cord-005453-4057qib7 2901 13 pts pt NNS cord-005453-4057qib7 2901 14 ) ) -RRB- cord-005453-4057qib7 2901 15 , , , cord-005453-4057qib7 2901 16 ALL all DT cord-005453-4057qib7 2901 17 ( ( -LRB- cord-005453-4057qib7 2901 18 8) 8) NN cord-005453-4057qib7 2901 19 , , , cord-005453-4057qib7 2901 20 MDS MDS NNP cord-005453-4057qib7 2901 21 ( ( -LRB- cord-005453-4057qib7 2901 22 2 2 CD cord-005453-4057qib7 2901 23 ) ) -RRB- cord-005453-4057qib7 2901 24 or or CC cord-005453-4057qib7 2901 25 Hodgkin Hodgkin NNP cord-005453-4057qib7 2901 26 ( ( -LRB- cord-005453-4057qib7 2901 27 1 1 CD cord-005453-4057qib7 2901 28 ) ) -RRB- cord-005453-4057qib7 2901 29 , , , cord-005453-4057qib7 2901 30 received receive VBD cord-005453-4057qib7 2901 31 a a DT cord-005453-4057qib7 2901 32 myeloblative myeloblative NN cord-005453-4057qib7 2901 33 ( ( -LRB- cord-005453-4057qib7 2901 34 busiphex busiphex NN cord-005453-4057qib7 2901 35 - - HYPH cord-005453-4057qib7 2901 36 based base VBN cord-005453-4057qib7 2901 37 : : : cord-005453-4057qib7 2901 38 16 16 CD cord-005453-4057qib7 2901 39 , , , cord-005453-4057qib7 2901 40 TBI TBI NNP cord-005453-4057qib7 2901 41 - - HYPH cord-005453-4057qib7 2901 42 based:1 based:1 NNP cord-005453-4057qib7 2901 43 ) ) -RRB- cord-005453-4057qib7 2901 44 or or CC cord-005453-4057qib7 2901 45 RIC RIC NNP cord-005453-4057qib7 2901 46 ( ( -LRB- cord-005453-4057qib7 2901 47 2 2 CD cord-005453-4057qib7 2901 48 ) ) -RRB- cord-005453-4057qib7 2901 49 conditioning conditioning NN cord-005453-4057qib7 2901 50 and and CC cord-005453-4057qib7 2901 51 were be VBD cord-005453-4057qib7 2901 52 transplanted transplant VBN cord-005453-4057qib7 2901 53 from from IN cord-005453-4057qib7 2901 54 a a DT cord-005453-4057qib7 2901 55 sibling sibling NN cord-005453-4057qib7 2901 56 ( ( -LRB- cord-005453-4057qib7 2901 57 5 5 CD cord-005453-4057qib7 2901 58 ) ) -RRB- cord-005453-4057qib7 2901 59 , , , cord-005453-4057qib7 2901 60 VUD VUD NNP cord-005453-4057qib7 2901 61 ( ( -LRB- cord-005453-4057qib7 2901 62 11 11 CD cord-005453-4057qib7 2901 63 ) ) -RRB- cord-005453-4057qib7 2901 64 or or CC cord-005453-4057qib7 2901 65 haploidentical haploidentical JJ cord-005453-4057qib7 2901 66 ( ( -LRB- cord-005453-4057qib7 2901 67 3 3 CD cord-005453-4057qib7 2901 68 ) ) -RRB- cord-005453-4057qib7 2901 69 donor donor NN cord-005453-4057qib7 2901 70 with with IN cord-005453-4057qib7 2901 71 PBSC PBSC NNP cord-005453-4057qib7 2901 72 ( ( -LRB- cord-005453-4057qib7 2901 73 16 16 CD cord-005453-4057qib7 2901 74 ) ) -RRB- cord-005453-4057qib7 2901 75 or or CC cord-005453-4057qib7 2901 76 BM BM NNP cord-005453-4057qib7 2901 77 ( ( -LRB- cord-005453-4057qib7 2901 78 3 3 CD cord-005453-4057qib7 2901 79 ) ) -RRB- cord-005453-4057qib7 2901 80 . . . cord-005453-4057qib7 2902 1 All all DT cord-005453-4057qib7 2902 2 patients patient NNS cord-005453-4057qib7 2902 3 revealed reveal VBD cord-005453-4057qib7 2902 4 primary primary JJ cord-005453-4057qib7 2902 5 neutrophil neutrophil NN cord-005453-4057qib7 2902 6 ( ( -LRB- cord-005453-4057qib7 2902 7 median median NN cord-005453-4057qib7 2902 8 14 14 CD cord-005453-4057qib7 2902 9 days day NNS cord-005453-4057qib7 2902 10 , , , cord-005453-4057qib7 2902 11 range range VBP cord-005453-4057qib7 2902 12 10 10 CD cord-005453-4057qib7 2902 13 - - SYM cord-005453-4057qib7 2902 14 19 19 CD cord-005453-4057qib7 2902 15 ) ) -RRB- cord-005453-4057qib7 2902 16 and and CC cord-005453-4057qib7 2902 17 > > XX cord-005453-4057qib7 2903 1 20.000 20.000 CD cord-005453-4057qib7 2903 2 / / SYM cord-005453-4057qib7 2903 3 μL μL NNP cord-005453-4057qib7 2903 4 platelet platelet NN cord-005453-4057qib7 2903 5 ( ( -LRB- cord-005453-4057qib7 2903 6 13 13 CD cord-005453-4057qib7 2903 7 days day NNS cord-005453-4057qib7 2903 8 , , , cord-005453-4057qib7 2903 9 7 7 CD cord-005453-4057qib7 2903 10 - - SYM cord-005453-4057qib7 2903 11 31 31 CD cord-005453-4057qib7 2903 12 ) ) -RRB- cord-005453-4057qib7 2903 13 engraftment engraftment NN cord-005453-4057qib7 2903 14 . . . cord-005453-4057qib7 2904 1 Romiplostim Romiplostim NNP cord-005453-4057qib7 2904 2 was be VBD cord-005453-4057qib7 2904 3 started start VBN cord-005453-4057qib7 2904 4 at at IN cord-005453-4057qib7 2904 5 median median JJ cord-005453-4057qib7 2904 6 day day NN cord-005453-4057qib7 2904 7 +104 +104 NNP cord-005453-4057qib7 2904 8 ( ( -LRB- cord-005453-4057qib7 2904 9 range range NN cord-005453-4057qib7 2904 10 58 58 CD cord-005453-4057qib7 2904 11 - - SYM cord-005453-4057qib7 2904 12 419 419 CD cord-005453-4057qib7 2904 13 ) ) -RRB- cord-005453-4057qib7 2904 14 with with IN cord-005453-4057qib7 2904 15 a a DT cord-005453-4057qib7 2904 16 median median NN cord-005453-4057qib7 2904 17 dose dose NN cord-005453-4057qib7 2904 18 5 5 CD cord-005453-4057qib7 2904 19 μg μg NN cord-005453-4057qib7 2904 20 / / SYM cord-005453-4057qib7 2904 21 kg kg NNP cord-005453-4057qib7 2904 22 ( ( -LRB- cord-005453-4057qib7 2904 23 1 1 CD cord-005453-4057qib7 2904 24 ) ) -RRB- cord-005453-4057qib7 2904 25 ( ( -LRB- cord-005453-4057qib7 2904 26 2 2 LS cord-005453-4057qib7 2904 27 ) ) -RRB- cord-005453-4057qib7 2904 28 ( ( -LRB- cord-005453-4057qib7 2904 29 3 3 LS cord-005453-4057qib7 2904 30 ) ) -RRB- cord-005453-4057qib7 2904 31 ( ( -LRB- cord-005453-4057qib7 2904 32 4 4 LS cord-005453-4057qib7 2904 33 ) ) -RRB- cord-005453-4057qib7 2904 34 ( ( -LRB- cord-005453-4057qib7 2904 35 5 5 CD cord-005453-4057qib7 2904 36 ) ) -RRB- cord-005453-4057qib7 2904 37 . . . cord-005453-4057qib7 2905 1 The the DT cord-005453-4057qib7 2905 2 median median JJ cord-005453-4057qib7 2905 3 platelet platelet NN cord-005453-4057qib7 2905 4 count count NN cord-005453-4057qib7 2905 5 before before IN cord-005453-4057qib7 2905 6 commencement commencement NN cord-005453-4057qib7 2905 7 of of IN cord-005453-4057qib7 2905 8 treatment treatment NN cord-005453-4057qib7 2905 9 with with IN cord-005453-4057qib7 2905 10 romiplostim romiplostim NNS cord-005453-4057qib7 2905 11 was be VBD cord-005453-4057qib7 2905 12 24.000/ 24.000/ CD cord-005453-4057qib7 2906 1 μL μL . cord-005453-4057qib7 2907 1 ( ( -LRB- cord-005453-4057qib7 2907 2 range range NNP cord-005453-4057qib7 2907 3 12.000 12.000 CD cord-005453-4057qib7 2907 4 - - SYM cord-005453-4057qib7 2907 5 57.000 57.000 CD cord-005453-4057qib7 2907 6 ) ) -RRB- cord-005453-4057qib7 2907 7 and and CC cord-005453-4057qib7 2907 8 10 10 CD cord-005453-4057qib7 2907 9 them -PRON- PRP cord-005453-4057qib7 2907 10 ( ( -LRB- cord-005453-4057qib7 2907 11 59 59 CD cord-005453-4057qib7 2907 12 % % NN cord-005453-4057qib7 2907 13 ) ) -RRB- cord-005453-4057qib7 2907 14 were be VBD cord-005453-4057qib7 2907 15 transfusion transfusion NN cord-005453-4057qib7 2907 16 - - HYPH cord-005453-4057qib7 2907 17 dependent dependent JJ cord-005453-4057qib7 2907 18 . . . cord-005453-4057qib7 2908 1 In in IN cord-005453-4057qib7 2908 2 total total JJ cord-005453-4057qib7 2908 3 14/17 14/17 CD cord-005453-4057qib7 2908 4 ( ( -LRB- cord-005453-4057qib7 2908 5 82 82 CD cord-005453-4057qib7 2908 6 % % NN cord-005453-4057qib7 2908 7 ) ) -RRB- cord-005453-4057qib7 2908 8 patients patient NNS cord-005453-4057qib7 2908 9 responded respond VBD cord-005453-4057qib7 2908 10 to to IN cord-005453-4057qib7 2908 11 romiplostim romiplostim NNP cord-005453-4057qib7 2908 12 treatment treatment NN cord-005453-4057qib7 2908 13 . . . cord-005453-4057qib7 2909 1 Eight eight CD cord-005453-4057qib7 2909 2 out out IN cord-005453-4057qib7 2909 3 of of IN cord-005453-4057qib7 2909 4 the the DT cord-005453-4057qib7 2909 5 10 10 CD cord-005453-4057qib7 2909 6 ( ( -LRB- cord-005453-4057qib7 2909 7 80 80 CD cord-005453-4057qib7 2909 8 % % NN cord-005453-4057qib7 2909 9 ) ) -RRB- cord-005453-4057qib7 2909 10 transfusion transfusion NN cord-005453-4057qib7 2909 11 dependent dependent JJ cord-005453-4057qib7 2909 12 patients patient NNS cord-005453-4057qib7 2909 13 responded respond VBD cord-005453-4057qib7 2909 14 to to IN cord-005453-4057qib7 2909 15 the the DT cord-005453-4057qib7 2909 16 administration administration NN cord-005453-4057qib7 2909 17 of of IN cord-005453-4057qib7 2909 18 romiplostim romiplostim NNP cord-005453-4057qib7 2909 19 . . . cord-005453-4057qib7 2910 1 Six six CD cord-005453-4057qib7 2910 2 out out IN cord-005453-4057qib7 2910 3 of of IN cord-005453-4057qib7 2910 4 the the DT cord-005453-4057qib7 2910 5 7 7 CD cord-005453-4057qib7 2910 6 patients patient NNS cord-005453-4057qib7 2910 7 ( ( -LRB- cord-005453-4057qib7 2910 8 86 86 CD cord-005453-4057qib7 2910 9 % % NN cord-005453-4057qib7 2910 10 ) ) -RRB- cord-005453-4057qib7 2910 11 who who WP cord-005453-4057qib7 2910 12 were be VBD cord-005453-4057qib7 2910 13 transfusion transfusion NN cord-005453-4057qib7 2910 14 independent independent JJ cord-005453-4057qib7 2910 15 at at IN cord-005453-4057qib7 2910 16 romiplostin romiplostin NNP cord-005453-4057qib7 2910 17 initiation initiation NNP cord-005453-4057qib7 2910 18 ( ( -LRB- cord-005453-4057qib7 2910 19 PLT PLT NNP cord-005453-4057qib7 2910 20 median median NN cord-005453-4057qib7 2910 21 28.000 28.000 CD cord-005453-4057qib7 2911 1 /μL /μL NFP cord-005453-4057qib7 2911 2 , , , cord-005453-4057qib7 2911 3 range range VBP cord-005453-4057qib7 2911 4 19.000 19.000 CD cord-005453-4057qib7 2911 5 - - HYPH cord-005453-4057qib7 2911 6 56.000 56.000 CD cord-005453-4057qib7 2911 7 ) ) -RRB- cord-005453-4057qib7 2911 8 responded respond VBD cord-005453-4057qib7 2911 9 . . . cord-005453-4057qib7 2912 1 The the DT cord-005453-4057qib7 2912 2 median median JJ cord-005453-4057qib7 2912 3 duration duration NN cord-005453-4057qib7 2912 4 of of IN cord-005453-4057qib7 2912 5 treatment treatment NN cord-005453-4057qib7 2912 6 was be VBD cord-005453-4057qib7 2912 7 74 74 CD cord-005453-4057qib7 2912 8 days day NNS cord-005453-4057qib7 2912 9 ( ( -LRB- cord-005453-4057qib7 2912 10 15 15 CD cord-005453-4057qib7 2912 11 - - SYM cord-005453-4057qib7 2912 12 253 253 CD cord-005453-4057qib7 2912 13 ) ) -RRB- cord-005453-4057qib7 2912 14 and and CC cord-005453-4057qib7 2912 15 the the DT cord-005453-4057qib7 2912 16 median median NN cord-005453-4057qib7 2912 17 follow follow VBP cord-005453-4057qib7 2912 18 up up RP cord-005453-4057qib7 2912 19 from from IN cord-005453-4057qib7 2912 20 the the DT cord-005453-4057qib7 2912 21 commencement commencement NN cord-005453-4057qib7 2912 22 of of IN cord-005453-4057qib7 2912 23 romiplostim romiplostim NNS cord-005453-4057qib7 2912 24 was be VBD cord-005453-4057qib7 2912 25 177 177 CD cord-005453-4057qib7 2912 26 days day NNS cord-005453-4057qib7 2912 27 ( ( -LRB- cord-005453-4057qib7 2912 28 15 15 CD cord-005453-4057qib7 2912 29 - - SYM cord-005453-4057qib7 2912 30 1080 1080 CD cord-005453-4057qib7 2912 31 ) ) -RRB- cord-005453-4057qib7 2912 32 . . . cord-005453-4057qib7 2913 1 Three three CD cord-005453-4057qib7 2913 2 out out IN cord-005453-4057qib7 2913 3 of of IN cord-005453-4057qib7 2913 4 17 17 CD cord-005453-4057qib7 2913 5 ( ( -LRB- cord-005453-4057qib7 2913 6 18 18 CD cord-005453-4057qib7 2913 7 % % NN cord-005453-4057qib7 2913 8 ) ) -RRB- cord-005453-4057qib7 2913 9 patients patient NNS cord-005453-4057qib7 2913 10 experienced experience VBD cord-005453-4057qib7 2913 11 relapse relapse NN cord-005453-4057qib7 2913 12 of of IN cord-005453-4057qib7 2913 13 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2913 14 after after IN cord-005453-4057qib7 2913 15 discontinuation discontinuation NN cord-005453-4057qib7 2913 16 of of IN cord-005453-4057qib7 2913 17 romiplostim romiplostim NNS cord-005453-4057qib7 2913 18 and and CC cord-005453-4057qib7 2913 19 re re NN cord-005453-4057qib7 2913 20 - - NN cord-005453-4057qib7 2913 21 initiation initiation NN cord-005453-4057qib7 2913 22 of of IN cord-005453-4057qib7 2913 23 romiplostim romiplostim NNS cord-005453-4057qib7 2913 24 was be VBD cord-005453-4057qib7 2913 25 commenced commence VBN cord-005453-4057qib7 2913 26 in in IN cord-005453-4057qib7 2913 27 all all DT cord-005453-4057qib7 2913 28 of of IN cord-005453-4057qib7 2913 29 them -PRON- PRP cord-005453-4057qib7 2913 30 , , , cord-005453-4057qib7 2913 31 of of IN cord-005453-4057qib7 2913 32 which which WDT cord-005453-4057qib7 2913 33 2 2 CD cord-005453-4057qib7 2913 34 responded respond VBD cord-005453-4057qib7 2913 35 and and CC cord-005453-4057qib7 2913 36 1 1 CD cord-005453-4057qib7 2913 37 did do VBD cord-005453-4057qib7 2913 38 n't not RB cord-005453-4057qib7 2913 39 . . . cord-005453-4057qib7 2914 1 The the DT cord-005453-4057qib7 2914 2 administration administration NN cord-005453-4057qib7 2914 3 of of IN cord-005453-4057qib7 2914 4 romiplostim romiplostim NNP cord-005453-4057qib7 2914 5 was be VBD cord-005453-4057qib7 2914 6 done do VBN cord-005453-4057qib7 2914 7 on on IN cord-005453-4057qib7 2914 8 an an DT cord-005453-4057qib7 2914 9 external external JJ cord-005453-4057qib7 2914 10 basis basis NN cord-005453-4057qib7 2914 11 and and CC cord-005453-4057qib7 2914 12 was be VBD cord-005453-4057qib7 2914 13 well well RB cord-005453-4057qib7 2914 14 tolerated tolerate VBN cord-005453-4057qib7 2914 15 by by IN cord-005453-4057qib7 2914 16 the the DT cord-005453-4057qib7 2914 17 patients patient NNS cord-005453-4057qib7 2914 18 . . . cord-005453-4057qib7 2915 1 Two two CD cord-005453-4057qib7 2915 2 patients patient NNS cord-005453-4057qib7 2915 3 experienced experience VBD cord-005453-4057qib7 2915 4 GvHD GvHD NNP cord-005453-4057qib7 2915 5 during during IN cord-005453-4057qib7 2915 6 romiplostim romiplostim NNP cord-005453-4057qib7 2915 7 treatment treatment NN cord-005453-4057qib7 2915 8 ( ( -LRB- cord-005453-4057qib7 2915 9 both both DT cord-005453-4057qib7 2915 10 patients patient NNS cord-005453-4057qib7 2915 11 transplanted transplant VBD cord-005453-4057qib7 2915 12 from from IN cord-005453-4057qib7 2915 13 7/8 7/8 CD cord-005453-4057qib7 2915 14 unrelated unrelated JJ cord-005453-4057qib7 2915 15 donor donor NN cord-005453-4057qib7 2915 16 , , , cord-005453-4057qib7 2915 17 25 25 CD cord-005453-4057qib7 2915 18 and and CC cord-005453-4057qib7 2915 19 42 42 CD cord-005453-4057qib7 2915 20 days day NNS cord-005453-4057qib7 2915 21 after after IN cord-005453-4057qib7 2915 22 initiation initiation NN cord-005453-4057qib7 2915 23 treatment treatment NN cord-005453-4057qib7 2915 24 with with IN cord-005453-4057qib7 2915 25 romiplostim romiplostim NNP cord-005453-4057qib7 2915 26 ) ) -RRB- cord-005453-4057qib7 2915 27 . . . cord-005453-4057qib7 2916 1 3/19 3/19 CD cord-005453-4057qib7 2916 2 patients patient NNS cord-005453-4057qib7 2916 3 interrupted interrupt VBD cord-005453-4057qib7 2916 4 romiplostim romiplostim NNP cord-005453-4057qib7 2916 5 due due IN cord-005453-4057qib7 2916 6 to to IN cord-005453-4057qib7 2916 7 disease disease NN cord-005453-4057qib7 2916 8 relapse relapse VB cord-005453-4057qib7 2916 9 . . . cord-005453-4057qib7 2917 1 11/19 11/19 CD cord-005453-4057qib7 2917 2 patients patient NNS cord-005453-4057qib7 2917 3 receiving receive VBG cord-005453-4057qib7 2917 4 romiplostim romiplostim NNS cord-005453-4057qib7 2917 5 are be VBP cord-005453-4057qib7 2917 6 alive alive JJ cord-005453-4057qib7 2917 7 in in IN cord-005453-4057qib7 2917 8 complete complete JJ cord-005453-4057qib7 2917 9 remission remission NN cord-005453-4057qib7 2917 10 and and CC cord-005453-4057qib7 2917 11 8 8 CD cord-005453-4057qib7 2917 12 died die VBD cord-005453-4057qib7 2917 13 ( ( -LRB- cord-005453-4057qib7 2917 14 3 3 CD cord-005453-4057qib7 2917 15 due due JJ cord-005453-4057qib7 2917 16 to to IN cord-005453-4057qib7 2917 17 relapse relapse NN cord-005453-4057qib7 2917 18 , , , cord-005453-4057qib7 2917 19 and and CC cord-005453-4057qib7 2917 20 5 5 CD cord-005453-4057qib7 2917 21 due due IN cord-005453-4057qib7 2917 22 to to IN cord-005453-4057qib7 2917 23 TRM TRM NNP cord-005453-4057qib7 2917 24 ) ) -RRB- cord-005453-4057qib7 2917 25 . . . cord-005453-4057qib7 2918 1 Conclusions conclusion NNS cord-005453-4057qib7 2918 2 : : : cord-005453-4057qib7 2919 1 We -PRON- PRP cord-005453-4057qib7 2919 2 present present VBP cord-005453-4057qib7 2919 3 high high JJ cord-005453-4057qib7 2919 4 response response NN cord-005453-4057qib7 2919 5 rates rate NNS cord-005453-4057qib7 2919 6 to to IN cord-005453-4057qib7 2919 7 romiplostim romiplostim NNS cord-005453-4057qib7 2919 8 in in IN cord-005453-4057qib7 2919 9 patients patient NNS cord-005453-4057qib7 2919 10 with with IN cord-005453-4057qib7 2919 11 prolonged prolonged JJ cord-005453-4057qib7 2919 12 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 2919 13 after after IN cord-005453-4057qib7 2919 14 allogeneic allogeneic NN cord-005453-4057qib7 2919 15 transplantation transplantation NN cord-005453-4057qib7 2919 16 . . . cord-005453-4057qib7 2920 1 In in IN cord-005453-4057qib7 2920 2 this this DT cord-005453-4057qib7 2920 3 retrospective retrospective JJ cord-005453-4057qib7 2920 4 study study NN cord-005453-4057qib7 2920 5 there there EX cord-005453-4057qib7 2920 6 were be VBD cord-005453-4057qib7 2920 7 no no DT cord-005453-4057qib7 2920 8 side side NN cord-005453-4057qib7 2920 9 effects effect NNS cord-005453-4057qib7 2920 10 from from IN cord-005453-4057qib7 2920 11 the the DT cord-005453-4057qib7 2920 12 administration administration NN cord-005453-4057qib7 2920 13 of of IN cord-005453-4057qib7 2920 14 romiplostim romiplostim NNP cord-005453-4057qib7 2920 15 . . . cord-005453-4057qib7 2921 1 However however RB cord-005453-4057qib7 2921 2 , , , cord-005453-4057qib7 2921 3 the the DT cord-005453-4057qib7 2921 4 administration administration NN cord-005453-4057qib7 2921 5 of of IN cord-005453-4057qib7 2921 6 romiplostim romiplostim NNP cord-005453-4057qib7 2921 7 after after IN cord-005453-4057qib7 2921 8 allo allo NN cord-005453-4057qib7 2921 9 - - HYPH cord-005453-4057qib7 2921 10 HCT hct NN cord-005453-4057qib7 2921 11 should should MD cord-005453-4057qib7 2921 12 be be VB cord-005453-4057qib7 2921 13 controlled control VBN cord-005453-4057qib7 2921 14 in in IN cord-005453-4057qib7 2921 15 prospective prospective JJ cord-005453-4057qib7 2921 16 trials trial NNS cord-005453-4057qib7 2921 17 . . . cord-005453-4057qib7 2922 1 Disclosure disclosure NN cord-005453-4057qib7 2923 1 We -PRON- PRP cord-005453-4057qib7 2923 2 report report VBP cord-005453-4057qib7 2923 3 a a DT cord-005453-4057qib7 2923 4 single single JJ cord-005453-4057qib7 2923 5 - - HYPH cord-005453-4057qib7 2923 6 center center NN cord-005453-4057qib7 2923 7 analysis analysis NN cord-005453-4057qib7 2923 8 of of IN cord-005453-4057qib7 2923 9 29 29 CD cord-005453-4057qib7 2923 10 adult adult NN cord-005453-4057qib7 2923 11 patients patient NNS cord-005453-4057qib7 2923 12 ( ( -LRB- cord-005453-4057qib7 2923 13 median median JJ cord-005453-4057qib7 2923 14 age age NN cord-005453-4057qib7 2923 15 22 22 CD cord-005453-4057qib7 2923 16 years year NNS cord-005453-4057qib7 2923 17 , , , cord-005453-4057qib7 2923 18 range range VBP cord-005453-4057qib7 2923 19 18 18 CD cord-005453-4057qib7 2923 20 - - SYM cord-005453-4057qib7 2923 21 57 57 CD cord-005453-4057qib7 2923 22 , , , cord-005453-4057qib7 2923 23 M M NNP cord-005453-4057qib7 2923 24 / / SYM cord-005453-4057qib7 2923 25 F F NNP cord-005453-4057qib7 2923 26 13/16 13/16 CD cord-005453-4057qib7 2923 27 ) ) -RRB- cord-005453-4057qib7 2923 28 , , , cord-005453-4057qib7 2923 29 receiving receive VBG cord-005453-4057qib7 2923 30 TPO TPO NNP cord-005453-4057qib7 2923 31 agonists agonist NNS cord-005453-4057qib7 2923 32 for for IN cord-005453-4057qib7 2923 33 isolated isolate VBN cord-005453-4057qib7 2923 34 severe severe JJ cord-005453-4057qib7 2923 35 thrombocytopenia thrombocytopenia NNS cord-005453-4057qib7 2923 36 ( ( -LRB- cord-005453-4057qib7 2923 37 n=7 n=7 NNS cord-005453-4057qib7 2923 38 ) ) -RRB- cord-005453-4057qib7 2923 39 and and CC cord-005453-4057qib7 2924 1 sPGF sPGF NNP cord-005453-4057qib7 2924 2 ( ( -LRB- cord-005453-4057qib7 2924 3 n=22 n=22 NNP cord-005453-4057qib7 2924 4 ) ) -RRB- cord-005453-4057qib7 2924 5 after after IN cord-005453-4057qib7 2924 6 allo allo NN cord-005453-4057qib7 2924 7 - - HYPH cord-005453-4057qib7 2924 8 HSCT HSCT NNP cord-005453-4057qib7 2924 9 . . . cord-005453-4057qib7 2925 1 Primary primary JJ cord-005453-4057qib7 2925 2 diagnoses diagnosis NNS cord-005453-4057qib7 2925 3 were be VBD cord-005453-4057qib7 2925 4 AML AML NNP cord-005453-4057qib7 2925 5 ( ( -LRB- cord-005453-4057qib7 2925 6 10 10 CD cord-005453-4057qib7 2925 7 ) ) -RRB- cord-005453-4057qib7 2925 8 , , , cord-005453-4057qib7 2925 9 ALL all DT cord-005453-4057qib7 2925 10 ( ( -LRB- cord-005453-4057qib7 2925 11 6 6 CD cord-005453-4057qib7 2925 12 ) ) -RRB- cord-005453-4057qib7 2925 13 , , , cord-005453-4057qib7 2925 14 MDS MDS NNP cord-005453-4057qib7 2925 15 ( ( -LRB- cord-005453-4057qib7 2925 16 7 7 CD cord-005453-4057qib7 2925 17 ) ) -RRB- cord-005453-4057qib7 2925 18 , , , cord-005453-4057qib7 2925 19 PMF PMF NNP cord-005453-4057qib7 2925 20 ( ( -LRB- cord-005453-4057qib7 2925 21 4 4 CD cord-005453-4057qib7 2925 22 ) ) -RRB- cord-005453-4057qib7 2925 23 , , , cord-005453-4057qib7 2925 24 MDS MDS NNP cord-005453-4057qib7 2925 25 / / SYM cord-005453-4057qib7 2925 26 MPN MPN NNP cord-005453-4057qib7 2925 27 ( ( -LRB- cord-005453-4057qib7 2925 28 4 4 CD cord-005453-4057qib7 2925 29 ) ) -RRB- cord-005453-4057qib7 2925 30 , , . cord-005453-4057qib7 2926 1 SAA SAA NNP cord-005453-4057qib7 2926 2 ( ( -LRB- cord-005453-4057qib7 2926 3 4 4 CD cord-005453-4057qib7 2926 4 ) ) -RRB- cord-005453-4057qib7 2926 5 , , , cord-005453-4057qib7 2926 6 CML CML NNP cord-005453-4057qib7 2926 7 ( ( -LRB- cord-005453-4057qib7 2926 8 1 1 CD cord-005453-4057qib7 2926 9 ) ) -RRB- cord-005453-4057qib7 2926 10 , , , cord-005453-4057qib7 2926 11 NHL NHL NNP cord-005453-4057qib7 2926 12 ( ( -LRB- cord-005453-4057qib7 2926 13 1 1 CD cord-005453-4057qib7 2926 14 ) ) -RRB- cord-005453-4057qib7 2926 15 . . . cord-005453-4057qib7 2927 1 Severe severe JJ cord-005453-4057qib7 2927 2 PGF PGF NNP cord-005453-4057qib7 2927 3 was be VBD cord-005453-4057qib7 2927 4 defined define VBN cord-005453-4057qib7 2927 5 as as IN cord-005453-4057qib7 2927 6 cytopenia cytopenia NNP cord-005453-4057qib7 2927 7 in in IN cord-005453-4057qib7 2927 8 ≥ ≥ CD cord-005453-4057qib7 2927 9 2 2 CD cord-005453-4057qib7 2927 10 lineages lineage NNS cord-005453-4057qib7 2927 11 ( ( -LRB- cord-005453-4057qib7 2927 12 platelet platelet NN cord-005453-4057qib7 2927 13 < < XX cord-005453-4057qib7 2927 14 20 20 CD cord-005453-4057qib7 2927 15 × × NN cord-005453-4057qib7 2927 16 10 10 CD cord-005453-4057qib7 2927 17 9 9 CD cord-005453-4057qib7 2927 18 /L /l CD cord-005453-4057qib7 2927 19 , , , cord-005453-4057qib7 2927 20 ANC ANC NNP cord-005453-4057qib7 2927 21 < < XX cord-005453-4057qib7 2927 22 0.5 0.5 CD cord-005453-4057qib7 2927 23 × × CD cord-005453-4057qib7 2927 24 10 10 CD cord-005453-4057qib7 2927 25 9 9 CD cord-005453-4057qib7 2927 26 /L /l CD cord-005453-4057qib7 2927 27 , , , cord-005453-4057qib7 2927 28 hemoglobin hemoglobin NN cord-005453-4057qib7 2927 29 < < XX cord-005453-4057qib7 2927 30 70 70 CD cord-005453-4057qib7 2927 31 g g NN cord-005453-4057qib7 2927 32 / / SYM cord-005453-4057qib7 2927 33 L l NN cord-005453-4057qib7 2927 34 any any DT cord-005453-4057qib7 2927 35 time time NN cord-005453-4057qib7 2927 36 after after IN cord-005453-4057qib7 2927 37 sustained sustained JJ cord-005453-4057qib7 2927 38 engraftment engraftment NN cord-005453-4057qib7 2927 39 ) ) -RRB- cord-005453-4057qib7 2927 40 , , , cord-005453-4057qib7 2927 41 full full JJ cord-005453-4057qib7 2927 42 or or CC cord-005453-4057qib7 2927 43 stable stable JJ cord-005453-4057qib7 2927 44 mixed mixed JJ cord-005453-4057qib7 2927 45 donor donor NN cord-005453-4057qib7 2927 46 chimerism chimerism NN cord-005453-4057qib7 2927 47 > > XX cord-005453-4057qib7 2927 48 90 90 CD cord-005453-4057qib7 2927 49 % % NN cord-005453-4057qib7 2927 50 and and CC cord-005453-4057qib7 2927 51 no no DT cord-005453-4057qib7 2927 52 signs sign NNS cord-005453-4057qib7 2927 53 of of IN cord-005453-4057qib7 2927 54 relapse relapse NN cord-005453-4057qib7 2927 55 . . . cord-005453-4057qib7 2928 1 Median median JJ cord-005453-4057qib7 2928 2 dose dose NN cord-005453-4057qib7 2928 3 of of IN cord-005453-4057qib7 2928 4 romiplostim romiplostim NNS cord-005453-4057qib7 2928 5 was be VBD cord-005453-4057qib7 2928 6 5 5 CD cord-005453-4057qib7 2929 1 ( ( -LRB- cord-005453-4057qib7 2929 2 range range NN cord-005453-4057qib7 2929 3 , , , cord-005453-4057qib7 2929 4 3 3 CD cord-005453-4057qib7 2929 5 - - SYM cord-005453-4057qib7 2929 6 5 5 CD cord-005453-4057qib7 2929 7 ) ) -RRB- cord-005453-4057qib7 2929 8 mcg mcg NN cord-005453-4057qib7 2929 9 / / SYM cord-005453-4057qib7 2929 10 kg kg NNP cord-005453-4057qib7 2929 11 weekly weekly NNP cord-005453-4057qib7 2929 12 , , , cord-005453-4057qib7 2929 13 eltrombopag eltrombopag NNP cord-005453-4057qib7 2929 14 -50 -50 NNP cord-005453-4057qib7 2930 1 ( ( -LRB- cord-005453-4057qib7 2930 2 range range NN cord-005453-4057qib7 2930 3 , , , cord-005453-4057qib7 2930 4 50 50 CD cord-005453-4057qib7 2930 5 - - SYM cord-005453-4057qib7 2930 6 150 150 CD cord-005453-4057qib7 2930 7 ) ) -RRB- cord-005453-4057qib7 2931 1 mg mg NNP cord-005453-4057qib7 2931 2 / / SYM cord-005453-4057qib7 2931 3 day day NN cord-005453-4057qib7 2931 4 . . . cord-005453-4057qib7 2932 1 Overall overall JJ cord-005453-4057qib7 2932 2 response response NN cord-005453-4057qib7 2932 3 ( ( -LRB- cord-005453-4057qib7 2932 4 OR or NN cord-005453-4057qib7 2932 5 ) ) -RRB- cord-005453-4057qib7 2932 6 included include VBD cord-005453-4057qib7 2932 7 CR CR NNP cord-005453-4057qib7 2932 8 ( ( -LRB- cord-005453-4057qib7 2932 9 platelet platelet NN cord-005453-4057qib7 2932 10 ≥ ≥ CD cord-005453-4057qib7 2932 11 100 100 CD cord-005453-4057qib7 2932 12 × × NN cord-005453-4057qib7 2932 13 10 10 CD cord-005453-4057qib7 2932 14 9 9 CD cord-005453-4057qib7 2932 15 /L /l CD cord-005453-4057qib7 2932 16 , , , cord-005453-4057qib7 2932 17 ANC ANC NNP cord-005453-4057qib7 2932 18 ≥ ≥ CD cord-005453-4057qib7 2932 19 1.5 1.5 CD cord-005453-4057qib7 2932 20 × × NN cord-005453-4057qib7 2932 21 10 10 CD cord-005453-4057qib7 2932 22 9 9 CD cord-005453-4057qib7 2932 23 /L /l CD cord-005453-4057qib7 2932 24 , , , cord-005453-4057qib7 2932 25 and and CC cord-005453-4057qib7 2932 26 hemoglobin hemoglobin NN cord-005453-4057qib7 2932 27 ≥ ≥ CD cord-005453-4057qib7 2932 28 100 100 CD cord-005453-4057qib7 2932 29 g g NN cord-005453-4057qib7 2932 30 / / SYM cord-005453-4057qib7 2932 31 l l NN cord-005453-4057qib7 2932 32 ) ) -RRB- cord-005453-4057qib7 2932 33 and and CC cord-005453-4057qib7 2932 34 PR PR NNP cord-005453-4057qib7 2932 35 ( ( -LRB- cord-005453-4057qib7 2932 36 platelet platelet NN cord-005453-4057qib7 2932 37 > > XX cord-005453-4057qib7 2933 1 20× 20× CD cord-005453-4057qib7 2933 2 10 10 CD cord-005453-4057qib7 2933 3 9 9 CD cord-005453-4057qib7 2933 4 /L /l CD cord-005453-4057qib7 2933 5 , , , cord-005453-4057qib7 2933 6 ANC ANC NNP cord-005453-4057qib7 2933 7 ≥ ≥ CD cord-005453-4057qib7 2933 8 0,5 0,5 NN cord-005453-4057qib7 2933 9 × × NN cord-005453-4057qib7 2933 10 10 10 CD cord-005453-4057qib7 2933 11 9 9 CD cord-005453-4057qib7 2933 12 /L /l CD cord-005453-4057qib7 2933 13 , , , cord-005453-4057qib7 2933 14 hemoglobin hemoglobin NN cord-005453-4057qib7 2933 15 > > XX cord-005453-4057qib7 2933 16 70 70 CD cord-005453-4057qib7 2933 17 g g NN cord-005453-4057qib7 2933 18 / / SYM cord-005453-4057qib7 2933 19 l l NN cord-005453-4057qib7 2933 20 ) ) -RRB- cord-005453-4057qib7 2933 21 . . . cord-005453-4057qib7 2934 1 Results result NNS cord-005453-4057qib7 2934 2 : : : cord-005453-4057qib7 2935 1 Median median JJ cord-005453-4057qib7 2935 2 time time NN cord-005453-4057qib7 2935 3 from from IN cord-005453-4057qib7 2935 4 PGF PGF NNP cord-005453-4057qib7 2935 5 diagnosis diagnosis NN cord-005453-4057qib7 2935 6 to to IN cord-005453-4057qib7 2935 7 treatment treatment NN cord-005453-4057qib7 2935 8 with with IN cord-005453-4057qib7 2935 9 TPO TPO NNP cord-005453-4057qib7 2935 10 agonists agonist NNS cord-005453-4057qib7 2935 11 was be VBD cord-005453-4057qib7 2935 12 14 14 CD cord-005453-4057qib7 2935 13 days day NNS cord-005453-4057qib7 2935 14 ( ( -LRB- cord-005453-4057qib7 2935 15 0 0 CD cord-005453-4057qib7 2935 16 - - SYM cord-005453-4057qib7 2935 17 119 119 CD cord-005453-4057qib7 2935 18 ) ) -RRB- cord-005453-4057qib7 2935 19 , , , cord-005453-4057qib7 2935 20 median median JJ cord-005453-4057qib7 2935 21 treatment treatment NN cord-005453-4057qib7 2935 22 duration duration NN cord-005453-4057qib7 2935 23 was be VBD cord-005453-4057qib7 2935 24 3 3 CD cord-005453-4057qib7 2935 25 weeks week NNS cord-005453-4057qib7 2935 26 ( ( -LRB- cord-005453-4057qib7 2935 27 1 1 CD cord-005453-4057qib7 2935 28 - - SYM cord-005453-4057qib7 2935 29 43 43 CD cord-005453-4057qib7 2935 30 ) ) -RRB- cord-005453-4057qib7 2935 31 . . . cord-005453-4057qib7 2936 1 TPO TPO NNP cord-005453-4057qib7 2936 2 agonists agonist NNS cord-005453-4057qib7 2936 3 were be VBD cord-005453-4057qib7 2936 4 well well RB cord-005453-4057qib7 2936 5 tolerated tolerate VBN cord-005453-4057qib7 2936 6 with with IN cord-005453-4057qib7 2936 7 no no DT cord-005453-4057qib7 2936 8 cases case NNS cord-005453-4057qib7 2936 9 of of IN cord-005453-4057qib7 2936 10 grade grade NN cord-005453-4057qib7 2936 11 III III NNP cord-005453-4057qib7 2936 12 - - HYPH cord-005453-4057qib7 2936 13 IV IV NNP cord-005453-4057qib7 2936 14 toxicity toxicity NN cord-005453-4057qib7 2936 15 . . . cord-005453-4057qib7 2937 1 TPO TPO NNP cord-005453-4057qib7 2937 2 agonists agonist NNS cord-005453-4057qib7 2937 3 were be VBD cord-005453-4057qib7 2937 4 combined combine VBN cord-005453-4057qib7 2937 5 with with IN cord-005453-4057qib7 2937 6 rituximab rituximab NN cord-005453-4057qib7 2937 7 ( ( -LRB- cord-005453-4057qib7 2937 8 n=4 n=4 NNP cord-005453-4057qib7 2937 9 ) ) -RRB- cord-005453-4057qib7 2937 10 , , , cord-005453-4057qib7 2937 11 rituximab rituximab NN cord-005453-4057qib7 2937 12 and and CC cord-005453-4057qib7 2937 13 DLI DLI NNP cord-005453-4057qib7 2937 14 ( ( -LRB- cord-005453-4057qib7 2937 15 n=3 n=3 NN cord-005453-4057qib7 2937 16 ) ) -RRB- cord-005453-4057qib7 2937 17 and and CC cord-005453-4057qib7 2937 18 HSC HSC NNP cord-005453-4057qib7 2937 19 boost boost NN cord-005453-4057qib7 2937 20 ( ( -LRB- cord-005453-4057qib7 2937 21 n=1 n=1 FW cord-005453-4057qib7 2937 22 ) ) -RRB- cord-005453-4057qib7 2937 23 in in IN cord-005453-4057qib7 2937 24 8 8 CD cord-005453-4057qib7 2937 25 ( ( -LRB- cord-005453-4057qib7 2937 26 28 28 CD cord-005453-4057qib7 2937 27 % % NN cord-005453-4057qib7 2937 28 ) ) -RRB- cord-005453-4057qib7 2937 29 patients patient NNS cord-005453-4057qib7 2937 30 . . . cord-005453-4057qib7 2938 1 A a DT cord-005453-4057qib7 2938 2 total total NN cord-005453-4057qib7 2938 3 of of IN cord-005453-4057qib7 2938 4 14 14 CD cord-005453-4057qib7 2938 5 ( ( -LRB- cord-005453-4057qib7 2938 6 48 48 CD cord-005453-4057qib7 2938 7 % % NN cord-005453-4057qib7 2938 8 ) ) -RRB- cord-005453-4057qib7 2938 9 patients patient NNS cord-005453-4057qib7 2938 10 met meet VBD cord-005453-4057qib7 2938 11 criteria criterion NNS cord-005453-4057qib7 2938 12 of of IN cord-005453-4057qib7 2938 13 response response NN cord-005453-4057qib7 2938 14 ( ( -LRB- cord-005453-4057qib7 2938 15 CR cr NN cord-005453-4057qib7 2938 16 : : : cord-005453-4057qib7 2938 17 n=4 n=4 JJ cord-005453-4057qib7 2938 18 , , , cord-005453-4057qib7 2938 19 14 14 CD cord-005453-4057qib7 2938 20 % % NN cord-005453-4057qib7 2938 21 ; ; : cord-005453-4057qib7 2938 22 PR pr NN cord-005453-4057qib7 2938 23 : : : cord-005453-4057qib7 2938 24 n=10 n=10 NNP cord-005453-4057qib7 2938 25 , , , cord-005453-4057qib7 2938 26 34 34 CD cord-005453-4057qib7 2938 27 % % NN cord-005453-4057qib7 2938 28 ) ) -RRB- cord-005453-4057qib7 2938 29 . . . cord-005453-4057qib7 2939 1 Combination combination NN cord-005453-4057qib7 2939 2 therapy therapy NN cord-005453-4057qib7 2939 3 showed show VBD cord-005453-4057qib7 2939 4 no no DT cord-005453-4057qib7 2939 5 difference difference NN cord-005453-4057qib7 2939 6 in in IN cord-005453-4057qib7 2939 7 OR or CC cord-005453-4057qib7 2939 8 compared compare VBN cord-005453-4057qib7 2939 9 to to IN cord-005453-4057qib7 2939 10 TPO TPO NNP cord-005453-4057qib7 2939 11 agonists agonist NNS cord-005453-4057qib7 2939 12 alone alone RB cord-005453-4057qib7 2939 13 . . . cord-005453-4057qib7 2940 1 OR or CC cord-005453-4057qib7 2940 2 was be VBD cord-005453-4057qib7 2940 3 not not RB cord-005453-4057qib7 2940 4 depended depend VBN cord-005453-4057qib7 2940 5 on on IN cord-005453-4057qib7 2940 6 the the DT cord-005453-4057qib7 2940 7 TPO TPO NNP cord-005453-4057qib7 2940 8 agonist agonist NN cord-005453-4057qib7 2940 9 used use VBD cord-005453-4057qib7 2940 10 nor nor CC cord-005453-4057qib7 2940 11 the the DT cord-005453-4057qib7 2940 12 time time NN cord-005453-4057qib7 2940 13 to to IN cord-005453-4057qib7 2940 14 therapy therapy NN cord-005453-4057qib7 2940 15 initiation initiation NN cord-005453-4057qib7 2940 16 . . . cord-005453-4057qib7 2941 1 Median median JJ cord-005453-4057qib7 2941 2 increase increase NN cord-005453-4057qib7 2941 3 in in IN cord-005453-4057qib7 2941 4 ANC ANC NNP cord-005453-4057qib7 2941 5 in in IN cord-005453-4057qib7 2941 6 responders responder NNS cord-005453-4057qib7 2941 7 was be VBD cord-005453-4057qib7 2941 8 3.4 3.4 CD cord-005453-4057qib7 2941 9 × × NN cord-005453-4057qib7 2941 10 10 10 CD cord-005453-4057qib7 2941 11 9 9 CD cord-005453-4057qib7 2941 12 /L /L . cord-005453-4057qib7 2941 13 ( ( -LRB- cord-005453-4057qib7 2941 14 0.8 0.8 CD cord-005453-4057qib7 2941 15 - - SYM cord-005453-4057qib7 2941 16 6.0 6.0 CD cord-005453-4057qib7 2941 17 ) ) -RRB- cord-005453-4057qib7 2941 18 , , , cord-005453-4057qib7 2941 19 in in IN cord-005453-4057qib7 2941 20 platelet platelet NN cord-005453-4057qib7 2941 21 count count NN cord-005453-4057qib7 2941 22 -48×10 -48×10 NNP cord-005453-4057qib7 2941 23 9 9 CD cord-005453-4057qib7 2941 24 /L /L . cord-005453-4057qib7 2941 25 ( ( -LRB- cord-005453-4057qib7 2941 26 21 21 CD cord-005453-4057qib7 2941 27 - - SYM cord-005453-4057qib7 2941 28 205 205 CD cord-005453-4057qib7 2941 29 ) ) -RRB- cord-005453-4057qib7 2941 30 . . . cord-005453-4057qib7 2942 1 A a DT cord-005453-4057qib7 2942 2 total total NN cord-005453-4057qib7 2942 3 of of IN cord-005453-4057qib7 2942 4 15 15 CD cord-005453-4057qib7 2942 5 patients patient NNS cord-005453-4057qib7 2942 6 died die VBD cord-005453-4057qib7 2942 7 due due IN cord-005453-4057qib7 2942 8 to to IN cord-005453-4057qib7 2942 9 relapse relapse NN cord-005453-4057qib7 2942 10 ( ( -LRB- cord-005453-4057qib7 2942 11 n=2 n=2 NNS cord-005453-4057qib7 2942 12 ) ) -RRB- cord-005453-4057qib7 2942 13 , , , cord-005453-4057qib7 2942 14 GVHD GVHD NNP cord-005453-4057qib7 2942 15 III III NNP cord-005453-4057qib7 2942 16 - - HYPH cord-005453-4057qib7 2942 17 IV IV NNP cord-005453-4057qib7 2942 18 grade grade NN cord-005453-4057qib7 2942 19 ( ( -LRB- cord-005453-4057qib7 2942 20 n=3 n=3 NN cord-005453-4057qib7 2942 21 ) ) -RRB- cord-005453-4057qib7 2942 22 and and CC cord-005453-4057qib7 2942 23 infection infection NN cord-005453-4057qib7 2942 24 ( ( -LRB- cord-005453-4057qib7 2942 25 n=10 n=10 NNP cord-005453-4057qib7 2942 26 ) ) -RRB- cord-005453-4057qib7 2942 27 . . . cord-005453-4057qib7 2943 1 Two two CD cord-005453-4057qib7 2943 2 - - HYPH cord-005453-4057qib7 2943 3 year year NN cord-005453-4057qib7 2943 4 OS os NN cord-005453-4057qib7 2943 5 from from IN cord-005453-4057qib7 2943 6 the the DT cord-005453-4057qib7 2943 7 start start NN cord-005453-4057qib7 2943 8 of of IN cord-005453-4057qib7 2943 9 TPO TPO NNP cord-005453-4057qib7 2943 10 agonist agonist NN cord-005453-4057qib7 2943 11 therapy therapy NN cord-005453-4057qib7 2943 12 was be VBD cord-005453-4057qib7 2943 13 44 44 CD cord-005453-4057qib7 2943 14 % % NN cord-005453-4057qib7 2943 15 ( ( -LRB- cord-005453-4057qib7 2943 16 95 95 CD cord-005453-4057qib7 2943 17 % % NN cord-005453-4057qib7 2943 18 CI CI NNP cord-005453-4057qib7 2943 19 , , , cord-005453-4057qib7 2943 20 25 25 CD cord-005453-4057qib7 2943 21 - - SYM cord-005453-4057qib7 2943 22 62 62 CD cord-005453-4057qib7 2943 23 ) ) -RRB- cord-005453-4057qib7 2943 24 with with IN cord-005453-4057qib7 2943 25 a a DT cord-005453-4057qib7 2943 26 significant significant JJ cord-005453-4057qib7 2943 27 difference difference NN cord-005453-4057qib7 2943 28 between between IN cord-005453-4057qib7 2943 29 responders responder NNS cord-005453-4057qib7 2943 30 and and CC cord-005453-4057qib7 2943 31 non non NNS cord-005453-4057qib7 2943 32 - - NNS cord-005453-4057qib7 2943 33 responders responder NNS cord-005453-4057qib7 2943 34 : : : cord-005453-4057qib7 2943 35 71 71 CD cord-005453-4057qib7 2943 36 % % NN cord-005453-4057qib7 2943 37 ( ( -LRB- cord-005453-4057qib7 2943 38 95 95 CD cord-005453-4057qib7 2943 39 % % NN cord-005453-4057qib7 2943 40 CI CI NNP cord-005453-4057qib7 2943 41 , , , cord-005453-4057qib7 2943 42 33 33 CD cord-005453-4057qib7 2943 43 - - SYM cord-005453-4057qib7 2943 44 90 90 CD cord-005453-4057qib7 2943 45 ) ) -RRB- cord-005453-4057qib7 2943 46 vs. vs. IN cord-005453-4057qib7 2943 47 18 18 CD cord-005453-4057qib7 2943 48 % % NN cord-005453-4057qib7 2943 49 ( ( -LRB- cord-005453-4057qib7 2943 50 95 95 CD cord-005453-4057qib7 2943 51 % % NN cord-005453-4057qib7 2943 52 CI ci NN cord-005453-4057qib7 2943 53 , , , cord-005453-4057qib7 2943 54 3 3 CD cord-005453-4057qib7 2943 55 - - SYM cord-005453-4057qib7 2943 56 40 40 CD cord-005453-4057qib7 2943 57 ) ) -RRB- cord-005453-4057qib7 2943 58 ( ( -LRB- cord-005453-4057qib7 2943 59 p=0,002 p=0,002 NNP cord-005453-4057qib7 2943 60 ) ) -RRB- cord-005453-4057qib7 2943 61 . . . cord-005453-4057qib7 2944 1 Conclusions conclusion NNS cord-005453-4057qib7 2944 2 : : : cord-005453-4057qib7 2945 1 This this DT cord-005453-4057qib7 2945 2 study study NN cord-005453-4057qib7 2945 3 showed show VBD cord-005453-4057qib7 2945 4 promising promising JJ cord-005453-4057qib7 2945 5 results result NNS cord-005453-4057qib7 2945 6 of of IN cord-005453-4057qib7 2945 7 TPO TPO NNP cord-005453-4057qib7 2945 8 agonists agonist NNS cord-005453-4057qib7 2945 9 for for IN cord-005453-4057qib7 2945 10 management management NN cord-005453-4057qib7 2945 11 of of IN cord-005453-4057qib7 2945 12 sPGF sPGF NNP cord-005453-4057qib7 2945 13 . . . cord-005453-4057qib7 2946 1 Further further JJ cord-005453-4057qib7 2946 2 studies study NNS cord-005453-4057qib7 2946 3 are be VBP cord-005453-4057qib7 2946 4 warranted warrant VBN cord-005453-4057qib7 2946 5 to to TO cord-005453-4057qib7 2946 6 specify specify VB cord-005453-4057qib7 2946 7 optimal optimal JJ cord-005453-4057qib7 2946 8 timing timing NN cord-005453-4057qib7 2946 9 and and CC cord-005453-4057qib7 2946 10 dosing dose VBG cord-005453-4057qib7 2946 11 regimen regimen NN cord-005453-4057qib7 2946 12 , , , cord-005453-4057qib7 2946 13 predictors predictor NNS cord-005453-4057qib7 2946 14 of of IN cord-005453-4057qib7 2946 15 response response NN cord-005453-4057qib7 2946 16 . . . cord-005453-4057qib7 2947 1 [ [ -LRB- cord-005453-4057qib7 2947 2 [ [ -LRB- cord-005453-4057qib7 2947 3 P144 P144 NNP cord-005453-4057qib7 2947 4 Image image NN cord-005453-4057qib7 2947 5 ] ] -RRB- cord-005453-4057qib7 2947 6 1 1 CD cord-005453-4057qib7 2947 7 . . . cord-005453-4057qib7 2948 1 Two two CD cord-005453-4057qib7 2948 2 - - HYPH cord-005453-4057qib7 2948 3 year year NN cord-005453-4057qib7 2948 4 OS os NN cord-005453-4057qib7 2948 5 in in IN cord-005453-4057qib7 2948 6 responders responder NNS cord-005453-4057qib7 2948 7 and and CC cord-005453-4057qib7 2948 8 nonresponders nonresponder NNS cord-005453-4057qib7 2948 9 to to IN cord-005453-4057qib7 2948 10 TPO tpo VB cord-005453-4057qib7 2948 11 agonist agonist NN cord-005453-4057qib7 2948 12 therapy therapy NN cord-005453-4057qib7 2948 13 ] ] -RRB- cord-005453-4057qib7 2949 1 Disclosure disclosure NN cord-005453-4057qib7 2949 2 : : : cord-005453-4057qib7 2949 3 There there EX cord-005453-4057qib7 2949 4 are be VBP cord-005453-4057qib7 2949 5 conflicts conflict NNS cord-005453-4057qib7 2949 6 of of IN cord-005453-4057qib7 2949 7 interest interest NN cord-005453-4057qib7 2949 8 to to TO cord-005453-4057qib7 2949 9 disclose disclose VB cord-005453-4057qib7 2949 10 P145 p145 $ cord-005453-4057qib7 2949 11 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 2949 12 reactivation reactivation NN cord-005453-4057qib7 2949 13 kinetics kinetic NNS cord-005453-4057qib7 2949 14 and and CC cord-005453-4057qib7 2949 15 peak peak NN cord-005453-4057qib7 2949 16 titers titer NNS cord-005453-4057qib7 2949 17 as as IN cord-005453-4057qib7 2949 18 novel novel JJ cord-005453-4057qib7 2949 19 predictors predictor NNS cord-005453-4057qib7 2949 20 of of IN cord-005453-4057qib7 2949 21 survival survival NN cord-005453-4057qib7 2949 22 and and CC cord-005453-4057qib7 2949 23 relapse relapse NN cord-005453-4057qib7 2949 24 after after IN cord-005453-4057qib7 2949 25 allogeneic allogeneic NN cord-005453-4057qib7 2949 26 cell cell NN cord-005453-4057qib7 2949 27 transplantation transplantation NN cord-005453-4057qib7 2949 28 for for IN cord-005453-4057qib7 2949 29 hematologic hematologic JJ cord-005453-4057qib7 2949 30 malignancies malignancy NNS cord-005453-4057qib7 2949 31 Saskia Saskia NNP cord-005453-4057qib7 2949 32 Leserer Leserer NNP cord-005453-4057qib7 2949 33 1 1 CD cord-005453-4057qib7 2949 34 , , , cord-005453-4057qib7 2949 35 Evren Evren NNP cord-005453-4057qib7 2949 36 Bayraktar Bayraktar NNP cord-005453-4057qib7 2949 37 1 1 CD cord-005453-4057qib7 2949 38 , , , cord-005453-4057qib7 2949 39 Nikolaos Nikolaos NNP cord-005453-4057qib7 2949 40 Tsachakis Tsachakis NNP cord-005453-4057qib7 2949 41 - - HYPH cord-005453-4057qib7 2949 42 Mück Mück NNP cord-005453-4057qib7 2949 43 1 1 CD cord-005453-4057qib7 2949 44 , , , cord-005453-4057qib7 2949 45 Michael Michael NNP cord-005453-4057qib7 2949 46 Koldehoff Koldehoff NNP cord-005453-4057qib7 2949 47 1 1 CD cord-005453-4057qib7 2949 48 , , , cord-005453-4057qib7 2949 49 Lara Lara NNP cord-005453-4057qib7 2949 50 Kasperidus Kasperidus NNP cord-005453-4057qib7 2949 51 1 1 CD cord-005453-4057qib7 2949 52 , , , cord-005453-4057qib7 2949 53 Esteban Esteban NNP cord-005453-4057qib7 2949 54 Arrieta Arrieta NNP cord-005453-4057qib7 2949 55 - - HYPH cord-005453-4057qib7 2949 56 Bolanos Bolanos NNP cord-005453-4057qib7 2949 57 1 1 CD cord-005453-4057qib7 2949 58 , , , cord-005453-4057qib7 2949 59 Mirko Mirko NNP cord-005453-4057qib7 2949 60 Trilling Trilling NNP cord-005453-4057qib7 2949 61 1 1 CD cord-005453-4057qib7 2949 62 , , , cord-005453-4057qib7 2949 63 Katharina Katharina NNP cord-005453-4057qib7 2949 64 Fleischhauer Fleischhauer NNP cord-005453-4057qib7 2949 65 1 1 CD cord-005453-4057qib7 2949 66 , , , cord-005453-4057qib7 2949 67 Dietrich Dietrich NNP cord-005453-4057qib7 2949 68 W. W. NNP cord-005453-4057qib7 2949 69 Beelen Beelen NNP cord-005453-4057qib7 2949 70 1 1 CD cord-005453-4057qib7 2949 71 , , , cord-005453-4057qib7 2949 72 Amin Amin NNP cord-005453-4057qib7 2949 73 T. T. NNP cord-005453-4057qib7 2949 74 Turki Turki NNP cord-005453-4057qib7 2949 75 1 1 CD cord-005453-4057qib7 2949 76 1 1 CD cord-005453-4057qib7 2949 77 University University NNP cord-005453-4057qib7 2949 78 Hospital Hospital NNP cord-005453-4057qib7 2949 79 Essen Essen NNP cord-005453-4057qib7 2949 80 , , , cord-005453-4057qib7 2949 81 Essen Essen NNP cord-005453-4057qib7 2949 82 , , , cord-005453-4057qib7 2949 83 Germany Germany NNP cord-005453-4057qib7 2949 84 , , , cord-005453-4057qib7 2950 1 Background background NN cord-005453-4057qib7 2950 2 : : : cord-005453-4057qib7 2951 1 After after IN cord-005453-4057qib7 2951 2 allogeneic allogeneic JJ cord-005453-4057qib7 2951 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 2951 4 cell cell NN cord-005453-4057qib7 2951 5 transplantation transplantation NN cord-005453-4057qib7 2951 6 ( ( -LRB- cord-005453-4057qib7 2951 7 HCT HCT NNP cord-005453-4057qib7 2951 8 ) ) -RRB- cord-005453-4057qib7 2951 9 , , , cord-005453-4057qib7 2951 10 human human JJ cord-005453-4057qib7 2951 11 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 2951 12 ( ( -LRB- cord-005453-4057qib7 2951 13 CMV CMV NNP cord-005453-4057qib7 2951 14 ) ) -RRB- cord-005453-4057qib7 2951 15 reactivation reactivation NN cord-005453-4057qib7 2951 16 associates associate NNS cord-005453-4057qib7 2951 17 with with IN cord-005453-4057qib7 2951 18 non non JJ cord-005453-4057qib7 2951 19 - - JJ cord-005453-4057qib7 2951 20 relapse relapse JJ cord-005453-4057qib7 2951 21 mortality mortality NN cord-005453-4057qib7 2951 22 ( ( -LRB- cord-005453-4057qib7 2951 23 NRM NRM NNP cord-005453-4057qib7 2951 24 ) ) -RRB- cord-005453-4057qib7 2951 25 but but CC cord-005453-4057qib7 2951 26 also also RB cord-005453-4057qib7 2951 27 with with IN cord-005453-4057qib7 2951 28 reduced reduce VBN cord-005453-4057qib7 2951 29 relapse relapse NN cord-005453-4057qib7 2951 30 in in IN cord-005453-4057qib7 2951 31 patients patient NNS cord-005453-4057qib7 2951 32 with with IN cord-005453-4057qib7 2951 33 leukemia leukemia NN cord-005453-4057qib7 2951 34 , , , cord-005453-4057qib7 2951 35 as as IN cord-005453-4057qib7 2951 36 shown show VBN cord-005453-4057qib7 2951 37 by by IN cord-005453-4057qib7 2951 38 numerous numerous JJ cord-005453-4057qib7 2951 39 studies study NNS cord-005453-4057qib7 2951 40 that that WDT cord-005453-4057qib7 2951 41 evaluated evaluate VBD cord-005453-4057qib7 2951 42 CMV CMV NNP cord-005453-4057qib7 2951 43 reactivation reactivation NN cord-005453-4057qib7 2951 44 as as IN cord-005453-4057qib7 2951 45 a a DT cord-005453-4057qib7 2951 46 qualitative qualitative JJ cord-005453-4057qib7 2951 47 yes yes UH cord-005453-4057qib7 2951 48 / / SYM cord-005453-4057qib7 2951 49 no no DT cord-005453-4057qib7 2951 50 parameter parameter NN cord-005453-4057qib7 2951 51 in in IN cord-005453-4057qib7 2951 52 the the DT cord-005453-4057qib7 2951 53 first first JJ cord-005453-4057qib7 2951 54 months month NNS cord-005453-4057qib7 2951 55 posttransplant posttransplant NNP cord-005453-4057qib7 2951 56 . . . cord-005453-4057qib7 2952 1 We -PRON- PRP cord-005453-4057qib7 2952 2 hypothesized hypothesize VBD cord-005453-4057qib7 2952 3 that that IN cord-005453-4057qib7 2952 4 longitudinal longitudinal JJ cord-005453-4057qib7 2952 5 quantitative quantitative JJ cord-005453-4057qib7 2952 6 assessment assessment NN cord-005453-4057qib7 2952 7 of of IN cord-005453-4057qib7 2952 8 CMV CMV NNP cord-005453-4057qib7 2952 9 reactivation reactivation NN cord-005453-4057qib7 2952 10 kinetics kinetic NNS cord-005453-4057qib7 2952 11 and and CC cord-005453-4057qib7 2952 12 virus virus NN cord-005453-4057qib7 2952 13 loads load NNS cord-005453-4057qib7 2952 14 might may MD cord-005453-4057qib7 2952 15 improve improve VB cord-005453-4057qib7 2952 16 patient patient NN cord-005453-4057qib7 2952 17 - - HYPH cord-005453-4057qib7 2952 18 specific specific JJ cord-005453-4057qib7 2952 19 clinical clinical JJ cord-005453-4057qib7 2952 20 outcome outcome NN cord-005453-4057qib7 2952 21 associations association NNS cord-005453-4057qib7 2952 22 . . . cord-005453-4057qib7 2953 1 Methods method NNS cord-005453-4057qib7 2953 2 : : : cord-005453-4057qib7 2954 1 This this DT cord-005453-4057qib7 2954 2 retrospective retrospective JJ cord-005453-4057qib7 2954 3 study study NN cord-005453-4057qib7 2954 4 included include VBD cord-005453-4057qib7 2954 5 705 705 CD cord-005453-4057qib7 2954 6 patients patient NNS cord-005453-4057qib7 2954 7 with with IN cord-005453-4057qib7 2954 8 HCT hct NN cord-005453-4057qib7 2954 9 for for IN cord-005453-4057qib7 2954 10 hematologic hematologic JJ cord-005453-4057qib7 2954 11 malignancies malignancy NNS cord-005453-4057qib7 2954 12 treated treat VBN cord-005453-4057qib7 2954 13 between between IN cord-005453-4057qib7 2954 14 01/2012 01/2012 CD cord-005453-4057qib7 2954 15 and and CC cord-005453-4057qib7 2954 16 12/2017 12/2017 CD cord-005453-4057qib7 2954 17 at at IN cord-005453-4057qib7 2954 18 University University NNP cord-005453-4057qib7 2954 19 Hospital Hospital NNP cord-005453-4057qib7 2954 20 Essen Essen NNP cord-005453-4057qib7 2954 21 , , , cord-005453-4057qib7 2954 22 Germany Germany NNP cord-005453-4057qib7 2954 23 . . . cord-005453-4057qib7 2955 1 CMV CMV NNP cord-005453-4057qib7 2955 2 titers titer NNS cord-005453-4057qib7 2955 3 were be VBD cord-005453-4057qib7 2955 4 monitored monitor VBN cord-005453-4057qib7 2955 5 weekly weekly RB cord-005453-4057qib7 2955 6 by by IN cord-005453-4057qib7 2955 7 quantitative quantitative JJ cord-005453-4057qib7 2955 8 PCR PCR NNP cord-005453-4057qib7 2955 9 ( ( -LRB- cord-005453-4057qib7 2955 10 qPCR qPCR NNP cord-005453-4057qib7 2955 11 ) ) -RRB- cord-005453-4057qib7 2955 12 ; ; : cord-005453-4057qib7 2955 13 CMV CMV NNP cord-005453-4057qib7 2955 14 reactivation reactivation NN cord-005453-4057qib7 2955 15 was be VBD cord-005453-4057qib7 2955 16 defined define VBN cord-005453-4057qib7 2955 17 by by IN cord-005453-4057qib7 2955 18 a a DT cord-005453-4057qib7 2955 19 cutoff cutoff NN cord-005453-4057qib7 2955 20 of of IN cord-005453-4057qib7 2955 21 > > $ cord-005453-4057qib7 2955 22 500 500 CD cord-005453-4057qib7 2955 23 genome genome NN cord-005453-4057qib7 2955 24 copies copy NNS cord-005453-4057qib7 2955 25 per per IN cord-005453-4057qib7 2955 26 ml ml NN cord-005453-4057qib7 2955 27 . . . cord-005453-4057qib7 2956 1 Patients patient NNS cord-005453-4057qib7 2956 2 were be VBD cord-005453-4057qib7 2956 3 included include VBN cord-005453-4057qib7 2956 4 for for IN cord-005453-4057qib7 2956 5 analysis analysis NN cord-005453-4057qib7 2956 6 , , , cord-005453-4057qib7 2956 7 if if IN cord-005453-4057qib7 2956 8 at at RB cord-005453-4057qib7 2956 9 least least JJS cord-005453-4057qib7 2956 10 5 5 CD cord-005453-4057qib7 2956 11 measurements measurement NNS cord-005453-4057qib7 2956 12 were be VBD cord-005453-4057qib7 2956 13 available available JJ cord-005453-4057qib7 2956 14 during during IN cord-005453-4057qib7 2956 15 the the DT cord-005453-4057qib7 2956 16 first first JJ cord-005453-4057qib7 2956 17 200 200 CD cord-005453-4057qib7 2956 18 days day NNS cord-005453-4057qib7 2956 19 after after IN cord-005453-4057qib7 2956 20 HCT HCT NNP cord-005453-4057qib7 2956 21 . . . cord-005453-4057qib7 2957 1 In in IN cord-005453-4057qib7 2957 2 total total JJ cord-005453-4057qib7 2957 3 , , , cord-005453-4057qib7 2957 4 11,508 11,508 CD cord-005453-4057qib7 2957 5 samples sample NNS cord-005453-4057qib7 2957 6 were be VBD cord-005453-4057qib7 2957 7 analyzed analyze VBN cord-005453-4057qib7 2957 8 . . . cord-005453-4057qib7 2958 1 Subgroup subgroup NN cord-005453-4057qib7 2958 2 analyses analysis NNS cord-005453-4057qib7 2958 3 were be VBD cord-005453-4057qib7 2958 4 performed perform VBN cord-005453-4057qib7 2958 5 according accord VBG cord-005453-4057qib7 2958 6 to to IN cord-005453-4057qib7 2958 7 the the DT cord-005453-4057qib7 2958 8 time time NN cord-005453-4057qib7 2958 9 of of IN cord-005453-4057qib7 2958 10 CMV CMV NNP cord-005453-4057qib7 2958 11 reactivation reactivation NN cord-005453-4057qib7 2958 12 ( ( -LRB- cord-005453-4057qib7 2958 13 before before IN cord-005453-4057qib7 2958 14 / / SYM cord-005453-4057qib7 2958 15 after after IN cord-005453-4057qib7 2958 16 +30d +30d NN cord-005453-4057qib7 2958 17 ) ) -RRB- cord-005453-4057qib7 2958 18 or or CC cord-005453-4057qib7 2958 19 the the DT cord-005453-4057qib7 2958 20 CMV CMV NNP cord-005453-4057qib7 2958 21 viremia viremia NN cord-005453-4057qib7 2958 22 titer titer NN cord-005453-4057qib7 2958 23 ( ( -LRB- cord-005453-4057qib7 2958 24 > > NFP cord-005453-4057qib7 2958 25 100,000 100,000 CD cord-005453-4057qib7 2958 26 , , , cord-005453-4057qib7 2958 27 20,000 20,000 CD cord-005453-4057qib7 2958 28 -100,000 -100,000 NNS cord-005453-4057qib7 2958 29 and and CC cord-005453-4057qib7 2958 30 500 500 CD cord-005453-4057qib7 2958 31 -20,000 -20,000 XX cord-005453-4057qib7 2959 1 copies copy NNS cord-005453-4057qib7 2959 2 / / SYM cord-005453-4057qib7 2959 3 ml ml NN cord-005453-4057qib7 2959 4 ) ) -RRB- cord-005453-4057qib7 2959 5 . . . cord-005453-4057qib7 2960 1 Results result NNS cord-005453-4057qib7 2960 2 : : : cord-005453-4057qib7 2961 1 CMV CMV NNP cord-005453-4057qib7 2961 2 reactivation reactivation NN cord-005453-4057qib7 2961 3 was be VBD cord-005453-4057qib7 2961 4 detected detect VBN cord-005453-4057qib7 2961 5 in in IN cord-005453-4057qib7 2961 6 350 350 CD cord-005453-4057qib7 2961 7 ( ( -LRB- cord-005453-4057qib7 2961 8 median median NN cord-005453-4057qib7 2961 9 age age NN cord-005453-4057qib7 2961 10 58 58 CD cord-005453-4057qib7 2961 11 years year NNS cord-005453-4057qib7 2961 12 ; ; : cord-005453-4057qib7 2961 13 range range VBP cord-005453-4057qib7 2961 14 17 17 CD cord-005453-4057qib7 2961 15 - - SYM cord-005453-4057qib7 2961 16 76 76 CD cord-005453-4057qib7 2961 17 years year NNS cord-005453-4057qib7 2961 18 ) ) -RRB- cord-005453-4057qib7 2961 19 out out IN cord-005453-4057qib7 2961 20 of of IN cord-005453-4057qib7 2961 21 705 705 CD cord-005453-4057qib7 2961 22 patients patient NNS cord-005453-4057qib7 2961 23 . . . cord-005453-4057qib7 2962 1 Baseline baseline JJ cord-005453-4057qib7 2962 2 characteristics characteristic NNS cord-005453-4057qib7 2962 3 ( ( -LRB- cord-005453-4057qib7 2962 4 age age NN cord-005453-4057qib7 2962 5 , , , cord-005453-4057qib7 2962 6 gender gender NN cord-005453-4057qib7 2962 7 , , , cord-005453-4057qib7 2962 8 underlying underlie VBG cord-005453-4057qib7 2962 9 disease disease NN cord-005453-4057qib7 2962 10 , , , cord-005453-4057qib7 2962 11 transplant transplant NN cord-005453-4057qib7 2962 12 ) ) -RRB- cord-005453-4057qib7 2962 13 of of IN cord-005453-4057qib7 2962 14 patients patient NNS cord-005453-4057qib7 2962 15 without without IN cord-005453-4057qib7 2962 16 CMV CMV NNP cord-005453-4057qib7 2962 17 reactivation reactivation NN cord-005453-4057qib7 2962 18 were be VBD cord-005453-4057qib7 2962 19 comparable comparable JJ cord-005453-4057qib7 2962 20 . . . cord-005453-4057qib7 2963 1 CMV CMV NNP cord-005453-4057qib7 2963 2 reactivation reactivation NN cord-005453-4057qib7 2963 3 kinetics kinetic NNS cord-005453-4057qib7 2963 4 followed follow VBD cord-005453-4057qib7 2963 5 a a DT cord-005453-4057qib7 2963 6 Gaussian gaussian JJ cord-005453-4057qib7 2963 7 normal normal JJ cord-005453-4057qib7 2963 8 distribution distribution NN cord-005453-4057qib7 2963 9 with with IN cord-005453-4057qib7 2963 10 a a DT cord-005453-4057qib7 2963 11 median median JJ cord-005453-4057qib7 2963 12 first first JJ cord-005453-4057qib7 2963 13 reactivation reactivation NN cord-005453-4057qib7 2963 14 at at IN cord-005453-4057qib7 2963 15 +33d +33d RB cord-005453-4057qib7 2963 16 and and CC cord-005453-4057qib7 2963 17 peak peak VB cord-005453-4057qib7 2963 18 titers titer NNS cord-005453-4057qib7 2963 19 at at IN cord-005453-4057qib7 2963 20 +47d +47d NNPS cord-005453-4057qib7 2963 21 . . . cord-005453-4057qib7 2964 1 All all DT cord-005453-4057qib7 2964 2 except except IN cord-005453-4057qib7 2964 3 1 1 CD cord-005453-4057qib7 2964 4 patient patient NN cord-005453-4057qib7 2964 5 reactivated reactivate VBN cord-005453-4057qib7 2964 6 before before IN cord-005453-4057qib7 2964 7 100d 100d CD cord-005453-4057qib7 2964 8 , , , cord-005453-4057qib7 2964 9 40 40 CD cord-005453-4057qib7 2964 10 % % NN cord-005453-4057qib7 2964 11 before before RB cord-005453-4057qib7 2964 12 +30d +30d NN cord-005453-4057qib7 2964 13 . . . cord-005453-4057qib7 2965 1 Overall overall JJ cord-005453-4057qib7 2965 2 survival survival NN cord-005453-4057qib7 2965 3 ( ( -LRB- cord-005453-4057qib7 2965 4 OS OS NNP cord-005453-4057qib7 2965 5 ) ) -RRB- cord-005453-4057qib7 2965 6 of of IN cord-005453-4057qib7 2965 7 the the DT cord-005453-4057qib7 2965 8 CMV CMV NNP cord-005453-4057qib7 2965 9 reactivation reactivation NN cord-005453-4057qib7 2965 10 group group NN cord-005453-4057qib7 2965 11 as as IN cord-005453-4057qib7 2965 12 a a DT cord-005453-4057qib7 2965 13 whole whole NN cord-005453-4057qib7 2965 14 did do VBD cord-005453-4057qib7 2965 15 not not RB cord-005453-4057qib7 2965 16 significantly significantly RB cord-005453-4057qib7 2965 17 differ differ VB cord-005453-4057qib7 2965 18 from from IN cord-005453-4057qib7 2965 19 the the DT cord-005453-4057qib7 2965 20 non non JJ cord-005453-4057qib7 2965 21 - - JJ cord-005453-4057qib7 2965 22 reactivation reactivation JJ cord-005453-4057qib7 2965 23 group group NN cord-005453-4057qib7 2965 24 ( ( -LRB- cord-005453-4057qib7 2965 25 34 34 CD cord-005453-4057qib7 2965 26 vs. vs. NN cord-005453-4057qib7 2965 27 38 38 CD cord-005453-4057qib7 2965 28 months month NNS cord-005453-4057qib7 2965 29 ) ) -RRB- cord-005453-4057qib7 2965 30 . . . cord-005453-4057qib7 2966 1 However however RB cord-005453-4057qib7 2966 2 , , , cord-005453-4057qib7 2966 3 in in IN cord-005453-4057qib7 2966 4 subgroup subgroup NN cord-005453-4057qib7 2966 5 analyses analysis NNS cord-005453-4057qib7 2966 6 OS OS NNP cord-005453-4057qib7 2966 7 was be VBD cord-005453-4057qib7 2966 8 significantly significantly RB cord-005453-4057qib7 2966 9 reduced reduce VBN cord-005453-4057qib7 2966 10 in in IN cord-005453-4057qib7 2966 11 patients patient NNS cord-005453-4057qib7 2966 12 with with IN cord-005453-4057qib7 2966 13 very very RB cord-005453-4057qib7 2966 14 early early JJ cord-005453-4057qib7 2966 15 ( ( -LRB- cord-005453-4057qib7 2966 16 < < XX cord-005453-4057qib7 2966 17 +30d +30d -RRB- cord-005453-4057qib7 2966 18 ) ) -RRB- cord-005453-4057qib7 2966 19 compared compare VBN cord-005453-4057qib7 2966 20 to to IN cord-005453-4057qib7 2966 21 later later JJ cord-005453-4057qib7 2966 22 reactivation reactivation NN cord-005453-4057qib7 2966 23 ( ( -LRB- cord-005453-4057qib7 2966 24 17 17 CD cord-005453-4057qib7 2966 25 vs. vs. NN cord-005453-4057qib7 2966 26 59 59 CD cord-005453-4057qib7 2966 27 months month NNS cord-005453-4057qib7 2966 28 , , , cord-005453-4057qib7 2966 29 p=0.040 p=0.040 NNP cord-005453-4057qib7 2966 30 ) ) -RRB- cord-005453-4057qib7 2966 31 . . . cord-005453-4057qib7 2967 1 Moreover moreover RB cord-005453-4057qib7 2967 2 and and CC cord-005453-4057qib7 2967 3 importantly importantly RB cord-005453-4057qib7 2967 4 , , , cord-005453-4057qib7 2967 5 OS OS NNP cord-005453-4057qib7 2967 6 was be VBD cord-005453-4057qib7 2967 7 significantly significantly RB cord-005453-4057qib7 2967 8 reduced reduce VBN cord-005453-4057qib7 2967 9 in in IN cord-005453-4057qib7 2967 10 patients patient NNS cord-005453-4057qib7 2967 11 with with IN cord-005453-4057qib7 2967 12 CMV CMV NNP cord-005453-4057qib7 2967 13 reactivation reactivation NN cord-005453-4057qib7 2967 14 at at IN cord-005453-4057qib7 2967 15 high high JJ cord-005453-4057qib7 2967 16 titers titer NNS cord-005453-4057qib7 2967 17 of of IN cord-005453-4057qib7 2967 18 > > $ cord-005453-4057qib7 2967 19 100,000 100,000 CD cord-005453-4057qib7 2967 20 copies copy NNS cord-005453-4057qib7 2967 21 / / SYM cord-005453-4057qib7 2967 22 ml ml NNS cord-005453-4057qib7 2967 23 compared compare VBN cord-005453-4057qib7 2967 24 to to IN cord-005453-4057qib7 2967 25 those those DT cord-005453-4057qib7 2967 26 with with IN cord-005453-4057qib7 2967 27 lower low JJR cord-005453-4057qib7 2967 28 titers titer NNS cord-005453-4057qib7 2967 29 ( ( -LRB- cord-005453-4057qib7 2967 30 ( ( -LRB- cord-005453-4057qib7 2967 31 10 10 CD cord-005453-4057qib7 2967 32 vs. vs. NN cord-005453-4057qib7 2967 33 45 45 CD cord-005453-4057qib7 2967 34 months month NNS cord-005453-4057qib7 2967 35 ) ) -RRB- cord-005453-4057qib7 2968 1 p p LS cord-005453-4057qib7 2968 2 < < XX cord-005453-4057qib7 2969 1 0.0001).Cox 0.0001).cox LS cord-005453-4057qib7 2969 2 regression regression NN cord-005453-4057qib7 2969 3 analyses analysis NNS cord-005453-4057qib7 2969 4 confirmed confirm VBD cord-005453-4057qib7 2969 5 significantly significantly RB cord-005453-4057qib7 2969 6 reduced reduce VBN cord-005453-4057qib7 2969 7 OS os NN cord-005453-4057qib7 2969 8 for for IN cord-005453-4057qib7 2969 9 patients patient NNS cord-005453-4057qib7 2969 10 with with IN cord-005453-4057qib7 2969 11 CMV CMV NNP cord-005453-4057qib7 2969 12 reactivation reactivation NN cord-005453-4057qib7 2969 13 > > XX cord-005453-4057qib7 2969 14 100,000 100,000 CD cord-005453-4057qib7 2969 15 copies copy NNS cord-005453-4057qib7 2969 16 / / SYM cord-005453-4057qib7 2969 17 ml ml NN cord-005453-4057qib7 2969 18 and and CC cord-005453-4057qib7 2969 19 < < NNP cord-005453-4057qib7 2969 20 day day NN cord-005453-4057qib7 2969 21 +30 +30 CD cord-005453-4057qib7 2969 22 as as IN cord-005453-4057qib7 2969 23 compared compare VBN cord-005453-4057qib7 2969 24 to to IN cord-005453-4057qib7 2969 25 the the DT cord-005453-4057qib7 2969 26 other other JJ cord-005453-4057qib7 2969 27 cohorts cohort NNS cord-005453-4057qib7 2969 28 ( ( -LRB- cord-005453-4057qib7 2969 29 HR HR NNP cord-005453-4057qib7 2969 30 2.03 2.03 CD cord-005453-4057qib7 2969 31 , , , cord-005453-4057qib7 2969 32 95%CI 95%ci CD cord-005453-4057qib7 2969 33 1.45 1.45 CD cord-005453-4057qib7 2969 34 - - SYM cord-005453-4057qib7 2969 35 2.86 2.86 CD cord-005453-4057qib7 2969 36 , , , cord-005453-4057qib7 2969 37 p p NN cord-005453-4057qib7 2969 38 < < XX cord-005453-4057qib7 2969 39 0.0001 0.0001 CD cord-005453-4057qib7 2969 40 and and CC cord-005453-4057qib7 2969 41 HR HR NNP cord-005453-4057qib7 2969 42 1.36 1.36 CD cord-005453-4057qib7 2969 43 , , , cord-005453-4057qib7 2969 44 95 95 CD cord-005453-4057qib7 2969 45 % % NN cord-005453-4057qib7 2969 46 CI CI NNP cord-005453-4057qib7 2969 47 1.01 1.01 CD cord-005453-4057qib7 2969 48 - - SYM cord-005453-4057qib7 2969 49 1.83 1.83 CD cord-005453-4057qib7 2969 50 , , , cord-005453-4057qib7 2969 51 p=0.041 p=0.041 NNP cord-005453-4057qib7 2969 52 ) ) -RRB- cord-005453-4057qib7 2969 53 respectively respectively RB cord-005453-4057qib7 2969 54 ) ) -RRB- cord-005453-4057qib7 2969 55 . . . cord-005453-4057qib7 2970 1 The the DT cord-005453-4057qib7 2970 2 NRM NRM NNP cord-005453-4057qib7 2970 3 was be VBD cord-005453-4057qib7 2970 4 consistently consistently RB cord-005453-4057qib7 2970 5 higher high JJR cord-005453-4057qib7 2970 6 ( ( -LRB- cord-005453-4057qib7 2970 7 HR HR NNP cord-005453-4057qib7 2970 8 2.59 2.59 CD cord-005453-4057qib7 2970 9 ; ; : cord-005453-4057qib7 2970 10 95%CI 95%ci CD cord-005453-4057qib7 2970 11 , , , cord-005453-4057qib7 2970 12 1.69 1.69 CD cord-005453-4057qib7 2970 13 - - SYM cord-005453-4057qib7 2970 14 3.97 3.97 CD cord-005453-4057qib7 2970 15 , , , cord-005453-4057qib7 2970 16 p p NN cord-005453-4057qib7 2970 17 < < XX cord-005453-4057qib7 2970 18 0.0001 0.0001 CD cord-005453-4057qib7 2970 19 ) ) -RRB- cord-005453-4057qib7 2970 20 for for IN cord-005453-4057qib7 2970 21 patients patient NNS cord-005453-4057qib7 2970 22 with with IN cord-005453-4057qib7 2970 23 CMV CMV NNP cord-005453-4057qib7 2970 24 copies copy NNS cord-005453-4057qib7 2970 25 > > NFP cord-005453-4057qib7 2970 26 100,000 100,000 CD cord-005453-4057qib7 2970 27 / / SYM cord-005453-4057qib7 2970 28 ml ml NN cord-005453-4057qib7 2970 29 . . . cord-005453-4057qib7 2971 1 The the DT cord-005453-4057qib7 2971 2 risk risk NN cord-005453-4057qib7 2971 3 of of IN cord-005453-4057qib7 2971 4 hematologic hematologic JJ cord-005453-4057qib7 2971 5 relapse relapse NN cord-005453-4057qib7 2971 6 was be VBD cord-005453-4057qib7 2971 7 exclusively exclusively RB cord-005453-4057qib7 2971 8 reduced reduce VBN cord-005453-4057qib7 2971 9 in in IN cord-005453-4057qib7 2971 10 patients patient NNS cord-005453-4057qib7 2971 11 with with IN cord-005453-4057qib7 2971 12 a a DT cord-005453-4057qib7 2971 13 peak peak JJ cord-005453-4057qib7 2971 14 CMV CMV NNP cord-005453-4057qib7 2971 15 viremia viremia NN cord-005453-4057qib7 2971 16 between between IN cord-005453-4057qib7 2971 17 20,000 20,000 CD cord-005453-4057qib7 2971 18 and and CC cord-005453-4057qib7 2971 19 100,000 100,000 CD cord-005453-4057qib7 2971 20 copies copy NNS cord-005453-4057qib7 2971 21 / / SYM cord-005453-4057qib7 2971 22 ml ml NN cord-005453-4057qib7 2971 23 ( ( -LRB- cord-005453-4057qib7 2971 24 HR HR NNP cord-005453-4057qib7 2971 25 0.55 0.55 CD cord-005453-4057qib7 2971 26 , , , cord-005453-4057qib7 2971 27 95 95 CD cord-005453-4057qib7 2971 28 % % NN cord-005453-4057qib7 2971 29 CI CI NNP cord-005453-4057qib7 2971 30 0.32 0.32 CD cord-005453-4057qib7 2971 31 - - HYPH cord-005453-4057qib7 2971 32 0.95 0.95 CD cord-005453-4057qib7 2971 33 ; ; : cord-005453-4057qib7 2971 34 p=0.033 p=0.033 NNP cord-005453-4057qib7 2971 35 ) ) -RRB- cord-005453-4057qib7 2971 36 as as IN cord-005453-4057qib7 2971 37 compared compare VBN cord-005453-4057qib7 2971 38 to to IN cord-005453-4057qib7 2971 39 patients patient NNS cord-005453-4057qib7 2971 40 without without IN cord-005453-4057qib7 2971 41 CMV CMV NNP cord-005453-4057qib7 2971 42 reactivation reactivation NN cord-005453-4057qib7 2971 43 . . . cord-005453-4057qib7 2972 1 For for IN cord-005453-4057qib7 2972 2 other other JJ cord-005453-4057qib7 2972 3 levels level NNS cord-005453-4057qib7 2972 4 of of IN cord-005453-4057qib7 2972 5 CMV CMV NNP cord-005453-4057qib7 2972 6 reactivation reactivation NN cord-005453-4057qib7 2972 7 this this DT cord-005453-4057qib7 2972 8 effect effect NN cord-005453-4057qib7 2972 9 was be VBD cord-005453-4057qib7 2972 10 not not RB cord-005453-4057qib7 2972 11 observed observe VBN cord-005453-4057qib7 2972 12 . . . cord-005453-4057qib7 2973 1 Conclusions conclusion NNS cord-005453-4057qib7 2973 2 : : : cord-005453-4057qib7 2974 1 Our -PRON- PRP$ cord-005453-4057qib7 2974 2 data datum NNS cord-005453-4057qib7 2974 3 showed show VBD cord-005453-4057qib7 2974 4 that that IN cord-005453-4057qib7 2974 5 CMV CMV NNP cord-005453-4057qib7 2974 6 reactivations reactivation NNS cord-005453-4057qib7 2974 7 before before IN cord-005453-4057qib7 2974 8 +30d +30d NN cord-005453-4057qib7 2974 9 or or CC cord-005453-4057qib7 2974 10 with with IN cord-005453-4057qib7 2974 11 high high JJ cord-005453-4057qib7 2974 12 titers titer NNS cord-005453-4057qib7 2974 13 of of IN cord-005453-4057qib7 2974 14 > > $ cord-005453-4057qib7 2974 15 100,000 100,000 CD cord-005453-4057qib7 2974 16 copies copy NNS cord-005453-4057qib7 2974 17 / / SYM cord-005453-4057qib7 2974 18 ml ml NN cord-005453-4057qib7 2974 19 associated associate VBN cord-005453-4057qib7 2974 20 with with IN cord-005453-4057qib7 2974 21 significantly significantly RB cord-005453-4057qib7 2974 22 reduced reduce VBN cord-005453-4057qib7 2974 23 OS os NN cord-005453-4057qib7 2974 24 , , , cord-005453-4057qib7 2974 25 while while IN cord-005453-4057qib7 2974 26 CMV CMV NNP cord-005453-4057qib7 2974 27 reactivations reactivation NNS cord-005453-4057qib7 2974 28 at at IN cord-005453-4057qib7 2974 29 intermediate intermediate JJ cord-005453-4057qib7 2974 30 titers titer NNS cord-005453-4057qib7 2974 31 between between IN cord-005453-4057qib7 2974 32 20,000 20,000 CD cord-005453-4057qib7 2974 33 and and CC cord-005453-4057qib7 2974 34 100,000 100,000 CD cord-005453-4057qib7 2974 35 copies copy NNS cord-005453-4057qib7 2974 36 / / SYM cord-005453-4057qib7 2974 37 ml ml NNS cord-005453-4057qib7 2974 38 had have VBD cord-005453-4057qib7 2974 39 a a DT cord-005453-4057qib7 2974 40 positive positive JJ cord-005453-4057qib7 2974 41 impact impact NN cord-005453-4057qib7 2974 42 on on IN cord-005453-4057qib7 2974 43 relapse relapse NN cord-005453-4057qib7 2974 44 incidence incidence NN cord-005453-4057qib7 2974 45 . . . cord-005453-4057qib7 2975 1 These these DT cord-005453-4057qib7 2975 2 findings finding NNS cord-005453-4057qib7 2975 3 underline underline VBP cord-005453-4057qib7 2975 4 the the DT cord-005453-4057qib7 2975 5 complexity complexity NN cord-005453-4057qib7 2975 6 of of IN cord-005453-4057qib7 2975 7 CMV CMV NNP cord-005453-4057qib7 2975 8 reactivations reactivation NNS cord-005453-4057qib7 2975 9 after after IN cord-005453-4057qib7 2975 10 HCT hct NN cord-005453-4057qib7 2975 11 outcome outcome NN cord-005453-4057qib7 2975 12 , , , cord-005453-4057qib7 2975 13 and and CC cord-005453-4057qib7 2975 14 support support VB cord-005453-4057qib7 2975 15 longitudinal longitudinal JJ cord-005453-4057qib7 2975 16 evaluation evaluation NN cord-005453-4057qib7 2975 17 of of IN cord-005453-4057qib7 2975 18 CMV CMV NNP cord-005453-4057qib7 2975 19 titers titer NNS cord-005453-4057qib7 2975 20 and and CC cord-005453-4057qib7 2975 21 individualized individualized JJ cord-005453-4057qib7 2975 22 quantitative quantitative JJ cord-005453-4057qib7 2975 23 kinetics kinetics NN cord-005453-4057qib7 2975 24 models model NNS cord-005453-4057qib7 2975 25 for for IN cord-005453-4057qib7 2975 26 risk risk NN cord-005453-4057qib7 2975 27 assessment assessment NN cord-005453-4057qib7 2975 28 after after IN cord-005453-4057qib7 2975 29 HCT HCT NNP cord-005453-4057qib7 2975 30 to to TO cord-005453-4057qib7 2975 31 distinguish distinguish VB cord-005453-4057qib7 2975 32 the the DT cord-005453-4057qib7 2975 33 advantageous advantageous JJ cord-005453-4057qib7 2975 34 from from IN cord-005453-4057qib7 2975 35 the the DT cord-005453-4057qib7 2975 36 detrimental detrimental JJ cord-005453-4057qib7 2975 37 aspects aspect NNS cord-005453-4057qib7 2975 38 of of IN cord-005453-4057qib7 2975 39 CMV CMV NNP cord-005453-4057qib7 2975 40 reactivation reactivation NN cord-005453-4057qib7 2975 41 . . . cord-005453-4057qib7 2976 1 Disclosure disclosure NN cord-005453-4057qib7 2976 2 : : : cord-005453-4057qib7 2977 1 ATT ATT NNP cord-005453-4057qib7 2977 2 has have VBZ cord-005453-4057qib7 2977 3 received receive VBN cord-005453-4057qib7 2977 4 lecture lecture NN cord-005453-4057qib7 2977 5 fees fee NNS cord-005453-4057qib7 2977 6 from from IN cord-005453-4057qib7 2977 7 Jazz Jazz NNP cord-005453-4057qib7 2977 8 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 2977 9 and and CC cord-005453-4057qib7 2977 10 travel travel NN cord-005453-4057qib7 2977 11 subsidies subsidy NNS cord-005453-4057qib7 2977 12 from from IN cord-005453-4057qib7 2977 13 Neovii Neovii NNP cord-005453-4057qib7 2977 14 Biotech Biotech NNP cord-005453-4057qib7 2977 15 outside outside IN cord-005453-4057qib7 2977 16 the the DT cord-005453-4057qib7 2977 17 submitted submit VBN cord-005453-4057qib7 2977 18 work work NN cord-005453-4057qib7 2977 19 . . . cord-005453-4057qib7 2978 1 The the DT cord-005453-4057qib7 2978 2 other other JJ cord-005453-4057qib7 2978 3 authors author NNS cord-005453-4057qib7 2978 4 declare declare VBP cord-005453-4057qib7 2978 5 no no DT cord-005453-4057qib7 2978 6 competing compete VBG cord-005453-4057qib7 2978 7 financial financial JJ cord-005453-4057qib7 2978 8 interests interest NNS cord-005453-4057qib7 2978 9 within within IN cord-005453-4057qib7 2978 10 the the DT cord-005453-4057qib7 2978 11 submitted submit VBN cord-005453-4057qib7 2978 12 work work NN cord-005453-4057qib7 2978 13 . . . cord-005453-4057qib7 2979 1 Association Association NNP cord-005453-4057qib7 2979 2 of of IN cord-005453-4057qib7 2979 3 serum serum NN cord-005453-4057qib7 2979 4 ferritin ferritin NN cord-005453-4057qib7 2979 5 levels level NNS cord-005453-4057qib7 2979 6 before before IN cord-005453-4057qib7 2979 7 start start NN cord-005453-4057qib7 2979 8 of of IN cord-005453-4057qib7 2979 9 conditioning conditioning NN cord-005453-4057qib7 2979 10 with with IN cord-005453-4057qib7 2979 11 mortality mortality NN cord-005453-4057qib7 2979 12 after after IN cord-005453-4057qib7 2979 13 alloSCT alloSCT NNP cord-005453-4057qib7 2979 14 -a -a HYPH cord-005453-4057qib7 2979 15 prospective prospective JJ cord-005453-4057qib7 2979 16 , , , cord-005453-4057qib7 2979 17 non non JJ cord-005453-4057qib7 2979 18 - - JJ cord-005453-4057qib7 2979 19 interventional interventional JJ cord-005453-4057qib7 2979 20 study study NN cord-005453-4057qib7 2979 21 of of IN cord-005453-4057qib7 2979 22 the the DT cord-005453-4057qib7 2979 23 EBMT EBMT NNP cord-005453-4057qib7 2979 24 transplant transplant NN cord-005453-4057qib7 2979 25 complication complication NN cord-005453-4057qib7 2979 26 working work VBG cord-005453-4057qib7 2979 27 party party NN cord-005453-4057qib7 2979 28 Background Background NNP cord-005453-4057qib7 2979 29 : : : cord-005453-4057qib7 2980 1 Elevated elevated JJ cord-005453-4057qib7 2980 2 serum serum NN cord-005453-4057qib7 2980 3 ferritin ferritin NN cord-005453-4057qib7 2980 4 levels level NNS cord-005453-4057qib7 2980 5 occur occur VBP cord-005453-4057qib7 2980 6 due due JJ cord-005453-4057qib7 2980 7 to to IN cord-005453-4057qib7 2980 8 iron iron NN cord-005453-4057qib7 2980 9 overload overload NN cord-005453-4057qib7 2980 10 or or CC cord-005453-4057qib7 2980 11 during during IN cord-005453-4057qib7 2980 12 inflammation inflammation NN cord-005453-4057qib7 2980 13 and and CC cord-005453-4057qib7 2980 14 macrophage macrophage NN cord-005453-4057qib7 2980 15 activation activation NN cord-005453-4057qib7 2980 16 . . . cord-005453-4057qib7 2981 1 A a DT cord-005453-4057qib7 2981 2 correlation correlation NN cord-005453-4057qib7 2981 3 of of IN cord-005453-4057qib7 2981 4 high high JJ cord-005453-4057qib7 2981 5 serum serum NN cord-005453-4057qib7 2981 6 ferritin ferritin NN cord-005453-4057qib7 2981 7 levels level NNS cord-005453-4057qib7 2981 8 with with IN cord-005453-4057qib7 2981 9 increased increase VBN cord-005453-4057qib7 2981 10 mortality mortality NN cord-005453-4057qib7 2981 11 after after IN cord-005453-4057qib7 2981 12 alloSCT alloSCT NNP cord-005453-4057qib7 2981 13 has have VBZ cord-005453-4057qib7 2981 14 been be VBN cord-005453-4057qib7 2981 15 suggested suggest VBN cord-005453-4057qib7 2981 16 by by IN cord-005453-4057qib7 2981 17 several several JJ cord-005453-4057qib7 2981 18 retrospective retrospective JJ cord-005453-4057qib7 2981 19 analyses analysis NNS cord-005453-4057qib7 2981 20 as as RB cord-005453-4057qib7 2981 21 well well RB cord-005453-4057qib7 2981 22 as as IN cord-005453-4057qib7 2981 23 by by IN cord-005453-4057qib7 2981 24 two two CD cord-005453-4057qib7 2981 25 smaller small JJR cord-005453-4057qib7 2981 26 prospective prospective JJ cord-005453-4057qib7 2981 27 studies study NNS cord-005453-4057qib7 2981 28 . . . cord-005453-4057qib7 2982 1 Methods method NNS cord-005453-4057qib7 2982 2 : : : cord-005453-4057qib7 2983 1 This this DT cord-005453-4057qib7 2983 2 international international JJ cord-005453-4057qib7 2983 3 multicentric multicentric NNP cord-005453-4057qib7 2983 4 study study NN cord-005453-4057qib7 2983 5 aimed aim VBN cord-005453-4057qib7 2983 6 to to TO cord-005453-4057qib7 2983 7 study study VB cord-005453-4057qib7 2983 8 the the DT cord-005453-4057qib7 2983 9 association association NNP cord-005453-4057qib7 2983 10 of of IN cord-005453-4057qib7 2983 11 ferritin ferritin NNP cord-005453-4057qib7 2983 12 serum serum NN cord-005453-4057qib7 2983 13 levels level NNS cord-005453-4057qib7 2983 14 before before IN cord-005453-4057qib7 2983 15 start start NN cord-005453-4057qib7 2983 16 of of IN cord-005453-4057qib7 2983 17 conditioning conditioning NN cord-005453-4057qib7 2983 18 with with IN cord-005453-4057qib7 2983 19 alloSCT alloSCT NNP cord-005453-4057qib7 2983 20 outcome outcome NN cord-005453-4057qib7 2983 21 . . . cord-005453-4057qib7 2984 1 Patients patient NNS cord-005453-4057qib7 2984 2 with with IN cord-005453-4057qib7 2984 3 acute acute JJ cord-005453-4057qib7 2984 4 leukemia leukemia NN cord-005453-4057qib7 2984 5 , , , cord-005453-4057qib7 2984 6 lymphoma lymphoma NN cord-005453-4057qib7 2984 7 or or CC cord-005453-4057qib7 2984 8 MDS MDS NNP cord-005453-4057qib7 2984 9 receiving receive VBG cord-005453-4057qib7 2984 10 a a DT cord-005453-4057qib7 2984 11 matched match VBN cord-005453-4057qib7 2984 12 sibling sibling NN cord-005453-4057qib7 2984 13 alloSCT allosct NN cord-005453-4057qib7 2984 14 for for IN cord-005453-4057qib7 2984 15 the the DT cord-005453-4057qib7 2984 16 first first JJ cord-005453-4057qib7 2984 17 time time NN cord-005453-4057qib7 2984 18 were be VBD cord-005453-4057qib7 2984 19 considered consider VBN cord-005453-4057qib7 2984 20 for for IN cord-005453-4057qib7 2984 21 inclusion inclusion NN cord-005453-4057qib7 2984 22 , , , cord-005453-4057qib7 2984 23 regardless regardless RB cord-005453-4057qib7 2984 24 of of IN cord-005453-4057qib7 2984 25 conditioning conditioning NN cord-005453-4057qib7 2984 26 . . . cord-005453-4057qib7 2985 1 Data datum NNS cord-005453-4057qib7 2985 2 were be VBD cord-005453-4057qib7 2985 3 prospectively prospectively RB cord-005453-4057qib7 2985 4 collected collect VBN cord-005453-4057qib7 2985 5 between between IN cord-005453-4057qib7 2985 6 8/2014 8/2014 NNS cord-005453-4057qib7 2985 7 and and CC cord-005453-4057qib7 2985 8 2/2018 2/2018 CD cord-005453-4057qib7 2985 9 . . . cord-005453-4057qib7 2986 1 A a DT cord-005453-4057qib7 2986 2 comparison comparison NN cord-005453-4057qib7 2986 3 of of IN cord-005453-4057qib7 2986 4 outcomes outcome NNS cord-005453-4057qib7 2986 5 between between IN cord-005453-4057qib7 2986 6 patients patient NNS cord-005453-4057qib7 2986 7 with with IN cord-005453-4057qib7 2986 8 high high JJ cord-005453-4057qib7 2986 9 and and CC cord-005453-4057qib7 2986 10 low low JJ cord-005453-4057qib7 2986 11 ferritin ferritin NN cord-005453-4057qib7 2986 12 level level NN cord-005453-4057qib7 2986 13 was be VBD cord-005453-4057qib7 2986 14 performed perform VBN cord-005453-4057qib7 2986 15 using use VBG cord-005453-4057qib7 2986 16 univariate univariate JJ cord-005453-4057qib7 2986 17 analysis analysis NN cord-005453-4057qib7 2986 18 and and CC cord-005453-4057qib7 2986 19 multivariate multivariate JJ cord-005453-4057qib7 2986 20 analysis analysis NN cord-005453-4057qib7 2986 21 using use VBG cord-005453-4057qib7 2986 22 cause cause NN cord-005453-4057qib7 2986 23 - - HYPH cord-005453-4057qib7 2986 24 specific specific JJ cord-005453-4057qib7 2986 25 Cox Cox NNP cord-005453-4057qib7 2986 26 model model NN cord-005453-4057qib7 2986 27 . . . cord-005453-4057qib7 2987 1 Variables variable NNS cord-005453-4057qib7 2987 2 included include VBN cord-005453-4057qib7 2987 3 in in IN cord-005453-4057qib7 2987 4 the the DT cord-005453-4057qib7 2987 5 multivariate multivariate JJ cord-005453-4057qib7 2987 6 analyses analysis NNS cord-005453-4057qib7 2987 7 were be VBD cord-005453-4057qib7 2987 8 age age NN cord-005453-4057qib7 2987 9 , , , cord-005453-4057qib7 2987 10 sex sex NN cord-005453-4057qib7 2987 11 mismatch mismatch NN cord-005453-4057qib7 2987 12 , , , cord-005453-4057qib7 2987 13 diagnosis diagnosis NN cord-005453-4057qib7 2987 14 , , , cord-005453-4057qib7 2987 15 disease disease NN cord-005453-4057qib7 2987 16 status status NN cord-005453-4057qib7 2987 17 , , , cord-005453-4057qib7 2987 18 Karnofsky Karnofsky NNP cord-005453-4057qib7 2987 19 score score NN cord-005453-4057qib7 2987 20 , , , cord-005453-4057qib7 2987 21 number number NN cord-005453-4057qib7 2987 22 of of IN cord-005453-4057qib7 2987 23 CD34 CD34 NNP cord-005453-4057qib7 2987 24 cells cell NNS cord-005453-4057qib7 2987 25 given give VBN cord-005453-4057qib7 2987 26 , , , cord-005453-4057qib7 2987 27 intensity intensity NN cord-005453-4057qib7 2987 28 of of IN cord-005453-4057qib7 2987 29 conditioning conditioning NN cord-005453-4057qib7 2987 30 , , , cord-005453-4057qib7 2987 31 type type NN cord-005453-4057qib7 2987 32 of of IN cord-005453-4057qib7 2987 33 GVHD GVHD NNP cord-005453-4057qib7 2987 34 prophylaxis prophylaxis NN cord-005453-4057qib7 2987 35 , , , cord-005453-4057qib7 2987 36 ATG ATG NNP cord-005453-4057qib7 2987 37 use use NN cord-005453-4057qib7 2987 38 , , , cord-005453-4057qib7 2987 39 time time NN cord-005453-4057qib7 2987 40 from from IN cord-005453-4057qib7 2987 41 diagnosis diagnosis NN cord-005453-4057qib7 2987 42 to to IN cord-005453-4057qib7 2987 43 transplant transplant NN cord-005453-4057qib7 2987 44 , , , cord-005453-4057qib7 2987 45 year year NN cord-005453-4057qib7 2987 46 of of IN cord-005453-4057qib7 2987 47 transplant transplant NN cord-005453-4057qib7 2987 48 and and CC cord-005453-4057qib7 2987 49 CMV CMV NNP cord-005453-4057qib7 2987 50 status status NN cord-005453-4057qib7 2987 51 . . . cord-005453-4057qib7 2988 1 Results result NNS cord-005453-4057qib7 2988 2 : : : cord-005453-4057qib7 2989 1 Twenty twenty CD cord-005453-4057qib7 2989 2 centers center NNS cord-005453-4057qib7 2989 3 from from IN cord-005453-4057qib7 2989 4 10 10 CD cord-005453-4057qib7 2989 5 European european JJ cord-005453-4057qib7 2989 6 countries country NNS cord-005453-4057qib7 2989 7 reported report VBD cord-005453-4057qib7 2989 8 data datum NNS cord-005453-4057qib7 2989 9 on on IN cord-005453-4057qib7 2989 10 385 385 CD cord-005453-4057qib7 2989 11 alloSCT alloSCT NNP cord-005453-4057qib7 2989 12 recipients recipient NNS cord-005453-4057qib7 2989 13 . . . cord-005453-4057qib7 2990 1 Patient patient JJ cord-005453-4057qib7 2990 2 characteristics characteristic NNS cord-005453-4057qib7 2990 3 are be VBP cord-005453-4057qib7 2990 4 given give VBN cord-005453-4057qib7 2990 5 in in IN cord-005453-4057qib7 2990 6 Table Table NNP cord-005453-4057qib7 2990 7 1 1 CD cord-005453-4057qib7 2990 8 . . . cord-005453-4057qib7 2991 1 The the DT cord-005453-4057qib7 2991 2 ferritin ferritin NN cord-005453-4057qib7 2991 3 cut cut VBD cord-005453-4057qib7 2991 4 off off RP cord-005453-4057qib7 2991 5 point point NN cord-005453-4057qib7 2991 6 was be VBD cord-005453-4057qib7 2991 7 determined determine VBN cord-005453-4057qib7 2991 8 at at IN cord-005453-4057qib7 2991 9 1500μg 1500μg CD cord-005453-4057qib7 2991 10 / / SYM cord-005453-4057qib7 2991 11 l l NN cord-005453-4057qib7 2991 12 ( ( -LRB- cord-005453-4057qib7 2991 13 median median NN cord-005453-4057qib7 2991 14 of of IN cord-005453-4057qib7 2991 15 measured measured JJ cord-005453-4057qib7 2991 16 ferritin ferritin NN cord-005453-4057qib7 2991 17 levels level NNS cord-005453-4057qib7 2991 18 ) ) -RRB- cord-005453-4057qib7 2991 19 . . . cord-005453-4057qib7 2992 1 Overall overall JJ cord-005453-4057qib7 2992 2 survival survival NN cord-005453-4057qib7 2992 3 of of IN cord-005453-4057qib7 2992 4 alloSCT alloSCT NNP cord-005453-4057qib7 2992 5 recipients recipient NNS cord-005453-4057qib7 2992 6 with with IN cord-005453-4057qib7 2992 7 ferritin ferritin NN cord-005453-4057qib7 2992 8 levels level NNS cord-005453-4057qib7 2992 9 above above IN cord-005453-4057qib7 2992 10 cut cut VBD cord-005453-4057qib7 2992 11 off off RP cord-005453-4057qib7 2992 12 measured measure VBN cord-005453-4057qib7 2992 13 before before IN cord-005453-4057qib7 2992 14 start start NN cord-005453-4057qib7 2992 15 of of IN cord-005453-4057qib7 2992 16 conditioning conditioning NN cord-005453-4057qib7 2992 17 was be VBD cord-005453-4057qib7 2992 18 significantly significantly RB cord-005453-4057qib7 2992 19 shorter short JJR cord-005453-4057qib7 2992 20 ( ( -LRB- cord-005453-4057qib7 2992 21 Figure figure NN cord-005453-4057qib7 2992 22 1A 1a NN cord-005453-4057qib7 2992 23 , , , cord-005453-4057qib7 2992 24 univariate univariate JJ cord-005453-4057qib7 2992 25 HR=2.3 HR=2.3 NNP cord-005453-4057qib7 2992 26 CI=1.4 CI=1.4 NNP cord-005453-4057qib7 2992 27 - - HYPH cord-005453-4057qib7 2992 28 3.6 3.6 CD cord-005453-4057qib7 2992 29 p=0.00041 p=0.00041 NNP cord-005453-4057qib7 2992 30 ; ; : cord-005453-4057qib7 2992 31 multivariate multivariate JJ cord-005453-4057qib7 2992 32 HR=2.5 HR=2.5 NNP cord-005453-4057qib7 2992 33 , , , cord-005453-4057qib7 2992 34 CI=1.5 CI=1.5 NNP cord-005453-4057qib7 2992 35 - - HYPH cord-005453-4057qib7 2992 36 4.1 4.1 CD cord-005453-4057qib7 2992 37 , , , cord-005453-4057qib7 2992 38 p=0.0005 p=0.0005 NNP cord-005453-4057qib7 2992 39 ) ) -RRB- cord-005453-4057qib7 2992 40 . . . cord-005453-4057qib7 2993 1 Progression progression NN cord-005453-4057qib7 2993 2 - - HYPH cord-005453-4057qib7 2993 3 free free JJ cord-005453-4057qib7 2993 4 survival survival NN cord-005453-4057qib7 2993 5 was be VBD cord-005453-4057qib7 2993 6 also also RB cord-005453-4057qib7 2993 7 shorter short JJR cord-005453-4057qib7 2993 8 ( ( -LRB- cord-005453-4057qib7 2993 9 Figure figure NN cord-005453-4057qib7 2993 10 1B 1b NN cord-005453-4057qib7 2993 11 , , , cord-005453-4057qib7 2993 12 univariate univariate JJ cord-005453-4057qib7 2993 13 HR=2.1 HR=2.1 NNP cord-005453-4057qib7 2993 14 CI=1.4 CI=1.4 NNP cord-005453-4057qib7 2993 15 - - HYPH cord-005453-4057qib7 2993 16 3.2 3.2 CD cord-005453-4057qib7 2993 17 p=0.00014 p=0.00014 NNS cord-005453-4057qib7 2993 18 ; ; : cord-005453-4057qib7 2993 19 multivariate multivariate JJ cord-005453-4057qib7 2993 20 HR=2.4 HR=2.4 NNP cord-005453-4057qib7 2993 21 , , , cord-005453-4057qib7 2993 22 CI=1.6 CI=1.6 NNP cord-005453-4057qib7 2993 23 - - HYPH cord-005453-4057qib7 2993 24 3.8 3.8 CD cord-005453-4057qib7 2993 25 , , , cord-005453-4057qib7 2993 26 p p NN cord-005453-4057qib7 2993 27 < < XX cord-005453-4057qib7 2993 28 0.0001 0.0001 CD cord-005453-4057qib7 2993 29 ) ) -RRB- cord-005453-4057qib7 2993 30 . . . cord-005453-4057qib7 2994 1 Excess excess JJ cord-005453-4057qib7 2994 2 mortality mortality NN cord-005453-4057qib7 2994 3 in in IN cord-005453-4057qib7 2994 4 the the DT cord-005453-4057qib7 2994 5 high high JJ cord-005453-4057qib7 2994 6 ferritin ferritin NN cord-005453-4057qib7 2994 7 group group NN cord-005453-4057qib7 2994 8 was be VBD cord-005453-4057qib7 2994 9 due due JJ cord-005453-4057qib7 2994 10 to to IN cord-005453-4057qib7 2994 11 both both DT cord-005453-4057qib7 2994 12 higher high JJR cord-005453-4057qib7 2994 13 relapse relapse NN cord-005453-4057qib7 2994 14 incidence incidence NN cord-005453-4057qib7 2994 15 ( ( -LRB- cord-005453-4057qib7 2994 16 univariate univariate JJ cord-005453-4057qib7 2994 17 HR=1.7 HR=1.7 NNP cord-005453-4057qib7 2994 18 CI=1 CI=1 NNP cord-005453-4057qib7 2994 19 - - HYPH cord-005453-4057qib7 2994 20 2.8 2.8 CD cord-005453-4057qib7 2994 21 p=0.03 p=0.03 NNP cord-005453-4057qib7 2994 22 ; ; , cord-005453-4057qib7 2994 23 multivariate multivariate JJ cord-005453-4057qib7 2994 24 HR=2.2 HR=2.2 NNP cord-005453-4057qib7 2994 25 , , , cord-005453-4057qib7 2994 26 CI=1.2 CI=1.2 NNP cord-005453-4057qib7 2994 27 - - HYPH cord-005453-4057qib7 2994 28 3.8 3.8 CD cord-005453-4057qib7 2994 29 , , , cord-005453-4057qib7 2994 30 p=0.007 p=0.007 NNP cord-005453-4057qib7 2994 31 ) ) -RRB- cord-005453-4057qib7 2994 32 and and CC cord-005453-4057qib7 2994 33 increased increase VBN cord-005453-4057qib7 2994 34 non non JJ cord-005453-4057qib7 2994 35 - - JJ cord-005453-4057qib7 2994 36 relapse relapse JJ cord-005453-4057qib7 2994 37 mortality mortality NN cord-005453-4057qib7 2994 38 ( ( -LRB- cord-005453-4057qib7 2994 39 univariate univariate JJ cord-005453-4057qib7 2994 40 HR=3.1 HR=3.1 NNP cord-005453-4057qib7 2994 41 CI=1.5 CI=1.5 NNP cord-005453-4057qib7 2994 42 - - HYPH cord-005453-4057qib7 2994 43 6.3 6.3 CD cord-005453-4057qib7 2994 44 p=0.002 p=0.002 NNS cord-005453-4057qib7 2994 45 ; ; , cord-005453-4057qib7 2994 46 multivariate multivariate JJ cord-005453-4057qib7 2994 47 HR=3.1 HR=3.1 NNP cord-005453-4057qib7 2994 48 , , , cord-005453-4057qib7 2994 49 CI=1.5 CI=1.5 NNP cord-005453-4057qib7 2994 50 - - HYPH cord-005453-4057qib7 2994 51 6.4 6.4 CD cord-005453-4057qib7 2994 52 , , , cord-005453-4057qib7 2994 53 p=0.002 p=0.002 NNP cord-005453-4057qib7 2994 54 ) ) -RRB- cord-005453-4057qib7 2994 55 . . . cord-005453-4057qib7 2995 1 Non non JJ cord-005453-4057qib7 2995 2 - - JJ cord-005453-4057qib7 2995 3 relapse relapse JJ cord-005453-4057qib7 2995 4 mortality mortality NN cord-005453-4057qib7 2995 5 was be VBD cord-005453-4057qib7 2995 6 driven drive VBN cord-005453-4057qib7 2995 7 by by IN cord-005453-4057qib7 2995 8 significantly significantly RB cord-005453-4057qib7 2995 9 higher high JJR cord-005453-4057qib7 2995 10 infection infection NN cord-005453-4057qib7 2995 11 - - HYPH cord-005453-4057qib7 2995 12 related relate VBN cord-005453-4057qib7 2995 13 mortality mortality NN cord-005453-4057qib7 2995 14 in in IN cord-005453-4057qib7 2995 15 the the DT cord-005453-4057qib7 2995 16 high high JJ cord-005453-4057qib7 2995 17 ferritin ferritin NN cord-005453-4057qib7 2995 18 group group NN cord-005453-4057qib7 2995 19 ( ( -LRB- cord-005453-4057qib7 2995 20 univariate univariate JJ cord-005453-4057qib7 2995 21 HR=3.9 HR=3.9 NNP cord-005453-4057qib7 2995 22 CI=1.6 CI=1.6 NNP cord-005453-4057qib7 2995 23 - - : cord-005453-4057qib7 2995 24 9.7 9.7 CD cord-005453-4057qib7 2995 25 p p NN cord-005453-4057qib7 2995 26 = = SYM cord-005453-4057qib7 2995 27 0.003 0.003 CD cord-005453-4057qib7 2995 28 ; ; , cord-005453-4057qib7 2995 29 multivariate multivariate JJ cord-005453-4057qib7 2995 30 HR hr NN cord-005453-4057qib7 2995 31 = = SYM cord-005453-4057qib7 2995 32 3.9 3.9 CD cord-005453-4057qib7 2995 33 , , , cord-005453-4057qib7 2995 34 CI CI NNP cord-005453-4057qib7 2995 35 = = SYM cord-005453-4057qib7 2995 36 1.6 1.6 CD cord-005453-4057qib7 2995 37 - - SYM cord-005453-4057qib7 2995 38 9.7 9.7 CD cord-005453-4057qib7 2995 39 p p NN cord-005453-4057qib7 2995 40 = = SYM cord-005453-4057qib7 2995 41 0.003 0.003 CD cord-005453-4057qib7 2995 42 ) ) -RRB- cord-005453-4057qib7 2995 43 . . . cord-005453-4057qib7 2996 1 Acute acute JJ cord-005453-4057qib7 2996 2 and and CC cord-005453-4057qib7 2996 3 chronic chronic JJ cord-005453-4057qib7 2996 4 GVHD GVHD NNP cord-005453-4057qib7 2996 5 incidence incidence NN cord-005453-4057qib7 2996 6 or or CC cord-005453-4057qib7 2996 7 severity severity NN cord-005453-4057qib7 2996 8 were be VBD cord-005453-4057qib7 2996 9 not not RB cord-005453-4057qib7 2996 10 associated associate VBN cord-005453-4057qib7 2996 11 to to IN cord-005453-4057qib7 2996 12 serum serum NN cord-005453-4057qib7 2996 13 ferritin ferritin NN cord-005453-4057qib7 2996 14 levels level NNS cord-005453-4057qib7 2996 15 . . . cord-005453-4057qib7 2997 1 Conclusions conclusion NNS cord-005453-4057qib7 2997 2 : : : cord-005453-4057qib7 2998 1 Ferritin ferritin NN cord-005453-4057qib7 2998 2 levels level NNS cord-005453-4057qib7 2998 3 before before IN cord-005453-4057qib7 2998 4 start start NN cord-005453-4057qib7 2998 5 of of IN cord-005453-4057qib7 2998 6 conditioning conditioning NN cord-005453-4057qib7 2998 7 can can MD cord-005453-4057qib7 2998 8 serve serve VB cord-005453-4057qib7 2998 9 as as IN cord-005453-4057qib7 2998 10 routine routine JJ cord-005453-4057qib7 2998 11 laboratory laboratory NN cord-005453-4057qib7 2998 12 biomarker biomarker NN cord-005453-4057qib7 2998 13 to to TO cord-005453-4057qib7 2998 14 predict predict VB cord-005453-4057qib7 2998 15 mortality mortality NN cord-005453-4057qib7 2998 16 after after IN cord-005453-4057qib7 2998 17 alloSCT alloSCT NNP cord-005453-4057qib7 2998 18 . . . cord-005453-4057qib7 2999 1 Disclosure disclosure NN cord-005453-4057qib7 2999 2 : : : cord-005453-4057qib7 3000 1 The the DT cord-005453-4057qib7 3000 2 authors author NNS cord-005453-4057qib7 3000 3 declare declare VBP cord-005453-4057qib7 3000 4 no no DT cord-005453-4057qib7 3000 5 confict confict NN cord-005453-4057qib7 3000 6 of of IN cord-005453-4057qib7 3000 7 interest interest NN cord-005453-4057qib7 3000 8 related relate VBN cord-005453-4057qib7 3000 9 to to IN cord-005453-4057qib7 3000 10 this this DT cord-005453-4057qib7 3000 11 study study NN cord-005453-4057qib7 3000 12 P147 P147 NNP cord-005453-4057qib7 3000 13 Prediction Prediction NNP cord-005453-4057qib7 3000 14 of of IN cord-005453-4057qib7 3000 15 reduced reduce VBN cord-005453-4057qib7 3000 16 lung lung NN cord-005453-4057qib7 3000 17 function function NN cord-005453-4057qib7 3000 18 and and CC cord-005453-4057qib7 3000 19 acute acute JJ cord-005453-4057qib7 3000 20 GVHD GVHD NNP cord-005453-4057qib7 3000 21 by by IN cord-005453-4057qib7 3000 22 surfactant surfactant NN cord-005453-4057qib7 3000 23 protein protein NN cord-005453-4057qib7 3000 24 D d NN cord-005453-4057qib7 3000 25 in in IN cord-005453-4057qib7 3000 26 allogeneic allogeneic NN cord-005453-4057qib7 3000 27 stem stem NN cord-005453-4057qib7 3000 28 cell cell NN cord-005453-4057qib7 3000 29 transplantation transplantation NN cord-005453-4057qib7 3000 30 transplantation transplantation NN cord-005453-4057qib7 3000 31 ( ( -LRB- cord-005453-4057qib7 3000 32 HSCT HSCT NNP cord-005453-4057qib7 3000 33 ) ) -RRB- cord-005453-4057qib7 3000 34 and and CC cord-005453-4057qib7 3000 35 may may MD cord-005453-4057qib7 3000 36 progress progress VB cord-005453-4057qib7 3000 37 to to IN cord-005453-4057qib7 3000 38 bronchiolitis bronchiolitis NNP cord-005453-4057qib7 3000 39 obliterans obliterans NNP cord-005453-4057qib7 3000 40 that that WDT cord-005453-4057qib7 3000 41 has have VBZ cord-005453-4057qib7 3000 42 a a DT cord-005453-4057qib7 3000 43 high high JJ cord-005453-4057qib7 3000 44 mortality mortality NN cord-005453-4057qib7 3000 45 rate rate NN cord-005453-4057qib7 3000 46 . . . cord-005453-4057qib7 3001 1 Surfactant surfactant NN cord-005453-4057qib7 3001 2 protein protein NN cord-005453-4057qib7 3001 3 D d NN cord-005453-4057qib7 3001 4 ( ( -LRB- cord-005453-4057qib7 3001 5 SP SP NNP cord-005453-4057qib7 3001 6 - - HYPH cord-005453-4057qib7 3001 7 D D NNP cord-005453-4057qib7 3001 8 ) ) -RRB- cord-005453-4057qib7 3001 9 is be VBZ cord-005453-4057qib7 3001 10 an an DT cord-005453-4057qib7 3001 11 innate innate JJ cord-005453-4057qib7 3001 12 defense defense NN cord-005453-4057qib7 3001 13 molecule molecule NN cord-005453-4057qib7 3001 14 involved involve VBN cord-005453-4057qib7 3001 15 in in IN cord-005453-4057qib7 3001 16 immune immune JJ cord-005453-4057qib7 3001 17 regulation regulation NN cord-005453-4057qib7 3001 18 at at IN cord-005453-4057qib7 3001 19 the the DT cord-005453-4057qib7 3001 20 epithelial epithelial JJ cord-005453-4057qib7 3001 21 surfaces surface NNS cord-005453-4057qib7 3001 22 , , , cord-005453-4057qib7 3001 23 particularly particularly RB cord-005453-4057qib7 3001 24 in in IN cord-005453-4057qib7 3001 25 the the DT cord-005453-4057qib7 3001 26 lungs lung NNS cord-005453-4057qib7 3001 27 , , , cord-005453-4057qib7 3001 28 and and CC cord-005453-4057qib7 3001 29 elevated elevated JJ cord-005453-4057qib7 3001 30 levels level NNS cord-005453-4057qib7 3001 31 have have VBP cord-005453-4057qib7 3001 32 been be VBN cord-005453-4057qib7 3001 33 associated associate VBN cord-005453-4057qib7 3001 34 with with IN cord-005453-4057qib7 3001 35 exacerbation exacerbation NN cord-005453-4057qib7 3001 36 of of IN cord-005453-4057qib7 3001 37 chronic chronic JJ cord-005453-4057qib7 3001 38 obstructive obstructive JJ cord-005453-4057qib7 3001 39 pulmonary pulmonary JJ cord-005453-4057qib7 3001 40 disease disease NN cord-005453-4057qib7 3001 41 ( ( -LRB- cord-005453-4057qib7 3001 42 COPD COPD NNP cord-005453-4057qib7 3001 43 ) ) -RRB- cord-005453-4057qib7 3001 44 . . . cord-005453-4057qib7 3002 1 The the DT cord-005453-4057qib7 3002 2 aim aim NN cord-005453-4057qib7 3002 3 of of IN cord-005453-4057qib7 3002 4 this this DT cord-005453-4057qib7 3002 5 study study NN cord-005453-4057qib7 3002 6 was be VBD cord-005453-4057qib7 3002 7 to to TO cord-005453-4057qib7 3002 8 investigate investigate VB cord-005453-4057qib7 3002 9 , , , cord-005453-4057qib7 3002 10 whether whether IN cord-005453-4057qib7 3002 11 SP SP NNP cord-005453-4057qib7 3002 12 - - HYPH cord-005453-4057qib7 3002 13 D d NN cord-005453-4057qib7 3002 14 plasma plasma NN cord-005453-4057qib7 3002 15 levels level NNS cord-005453-4057qib7 3002 16 and and CC cord-005453-4057qib7 3002 17 variants variant NNS cord-005453-4057qib7 3002 18 in in IN cord-005453-4057qib7 3002 19 the the DT cord-005453-4057qib7 3002 20 gene gene NN cord-005453-4057qib7 3002 21 encoding encode VBG cord-005453-4057qib7 3002 22 SP SP NNP cord-005453-4057qib7 3002 23 - - HYPH cord-005453-4057qib7 3002 24 D D NNP cord-005453-4057qib7 3002 25 may may MD cord-005453-4057qib7 3002 26 predict predict VB cord-005453-4057qib7 3002 27 the the DT cord-005453-4057qib7 3002 28 development development NN cord-005453-4057qib7 3002 29 of of IN cord-005453-4057qib7 3002 30 reduced reduce VBN cord-005453-4057qib7 3002 31 lung lung NN cord-005453-4057qib7 3002 32 function function NN cord-005453-4057qib7 3002 33 after after IN cord-005453-4057qib7 3002 34 allogenic allogenic JJ cord-005453-4057qib7 3002 35 HSCT HSCT NNP cord-005453-4057qib7 3002 36 . . . cord-005453-4057qib7 3003 1 Methods method NNS cord-005453-4057qib7 3003 2 : : : cord-005453-4057qib7 3003 3 We -PRON- PRP cord-005453-4057qib7 3003 4 performed perform VBD cord-005453-4057qib7 3003 5 a a DT cord-005453-4057qib7 3003 6 population population NN cord-005453-4057qib7 3003 7 - - HYPH cord-005453-4057qib7 3003 8 based base VBN cord-005453-4057qib7 3003 9 , , , cord-005453-4057qib7 3003 10 singlecenter singlecenter JJ cord-005453-4057qib7 3003 11 study study NN cord-005453-4057qib7 3003 12 of of IN cord-005453-4057qib7 3003 13 children child NNS cord-005453-4057qib7 3003 14 ( ( -LRB- cord-005453-4057qib7 3003 15 aged aged JJ cord-005453-4057qib7 3003 16 6 6 CD cord-005453-4057qib7 3003 17 - - SYM cord-005453-4057qib7 3003 18 18 18 CD cord-005453-4057qib7 3003 19 years year NNS cord-005453-4057qib7 3003 20 ) ) -RRB- cord-005453-4057qib7 3003 21 treated treat VBN cord-005453-4057qib7 3003 22 with with IN cord-005453-4057qib7 3003 23 allogeneic allogeneic IN cord-005453-4057qib7 3003 24 HSCT HSCT NNP cord-005453-4057qib7 3003 25 . . . cord-005453-4057qib7 3004 1 The the DT cord-005453-4057qib7 3004 2 study study NN cord-005453-4057qib7 3004 3 consisted consist VBD cord-005453-4057qib7 3004 4 of of IN cord-005453-4057qib7 3004 5 1 1 CD cord-005453-4057qib7 3004 6 ) ) -RRB- cord-005453-4057qib7 3004 7 a a DT cord-005453-4057qib7 3004 8 prospective prospective JJ cord-005453-4057qib7 3004 9 study study NN cord-005453-4057qib7 3004 10 of of IN cord-005453-4057qib7 3004 11 serial serial JJ cord-005453-4057qib7 3004 12 plasma plasma NN cord-005453-4057qib7 3004 13 SP sp NN cord-005453-4057qib7 3004 14 - - HYPH cord-005453-4057qib7 3004 15 D d JJ cord-005453-4057qib7 3004 16 levels level NNS cord-005453-4057qib7 3004 17 and and CC cord-005453-4057qib7 3004 18 rs721917 rs721917 NNP cord-005453-4057qib7 3004 19 genotypes genotype NNS cord-005453-4057qib7 3004 20 in in IN cord-005453-4057qib7 3004 21 55 55 CD cord-005453-4057qib7 3004 22 patients patient NNS cord-005453-4057qib7 3004 23 during during IN cord-005453-4057qib7 3004 24 the the DT cord-005453-4057qib7 3004 25 first first JJ cord-005453-4057qib7 3004 26 6 6 CD cord-005453-4057qib7 3004 27 months month NNS cord-005453-4057qib7 3004 28 after after IN cord-005453-4057qib7 3004 29 HSCT HSCT NNP cord-005453-4057qib7 3004 30 , , , cord-005453-4057qib7 3004 31 and and CC cord-005453-4057qib7 3004 32 2 2 LS cord-005453-4057qib7 3004 33 ) ) -RRB- cord-005453-4057qib7 3004 34 a a DT cord-005453-4057qib7 3004 35 retrospective retrospective JJ cord-005453-4057qib7 3004 36 study study NN cord-005453-4057qib7 3004 37 of of IN cord-005453-4057qib7 3004 38 rs721917 rs721917 NNP cord-005453-4057qib7 3004 39 genotypes genotype NNS cord-005453-4057qib7 3004 40 within within IN cord-005453-4057qib7 3004 41 the the DT cord-005453-4057qib7 3004 42 SP SP NNP cord-005453-4057qib7 3004 43 - - HYPH cord-005453-4057qib7 3004 44 D d JJ cord-005453-4057qib7 3004 45 gene gene NN cord-005453-4057qib7 3004 46 in in IN cord-005453-4057qib7 3004 47 247 247 CD cord-005453-4057qib7 3004 48 patients patient NNS cord-005453-4057qib7 3004 49 transplanted transplant VBN cord-005453-4057qib7 3004 50 between between IN cord-005453-4057qib7 3004 51 1990 1990 CD cord-005453-4057qib7 3004 52 - - SYM cord-005453-4057qib7 3004 53 2017 2017 CD cord-005453-4057qib7 3004 54 . . . cord-005453-4057qib7 3005 1 Pulmonary pulmonary JJ cord-005453-4057qib7 3005 2 function function NN cord-005453-4057qib7 3005 3 tests test NNS cord-005453-4057qib7 3005 4 were be VBD cord-005453-4057qib7 3005 5 performed perform VBN cord-005453-4057qib7 3005 6 regularly regularly RB cord-005453-4057qib7 3005 7 as as IN cord-005453-4057qib7 3005 8 part part NN cord-005453-4057qib7 3005 9 of of IN cord-005453-4057qib7 3005 10 the the DT cord-005453-4057qib7 3005 11 clinical clinical JJ cord-005453-4057qib7 3005 12 monitoring monitoring NN cord-005453-4057qib7 3005 13 . . . cord-005453-4057qib7 3006 1 Results result NNS cord-005453-4057qib7 3006 2 : : : cord-005453-4057qib7 3007 1 At at IN cord-005453-4057qib7 3007 2 the the DT cord-005453-4057qib7 3007 3 day day NN cord-005453-4057qib7 3007 4 of of IN cord-005453-4057qib7 3007 5 graft graft NN cord-005453-4057qib7 3007 6 infusion infusion NN cord-005453-4057qib7 3007 7 ( ( -LRB- cord-005453-4057qib7 3007 8 day day NN cord-005453-4057qib7 3007 9 0 0 CD cord-005453-4057qib7 3007 10 ) ) -RRB- cord-005453-4057qib7 3007 11 SP SP NNP cord-005453-4057qib7 3007 12 - - HYPH cord-005453-4057qib7 3007 13 D d JJ cord-005453-4057qib7 3007 14 levels level NNS cord-005453-4057qib7 3007 15 were be VBD cord-005453-4057qib7 3007 16 reduced reduce VBN cord-005453-4057qib7 3007 17 compared compare VBN cord-005453-4057qib7 3007 18 to to IN cord-005453-4057qib7 3007 19 levels level NNS cord-005453-4057qib7 3007 20 before before IN cord-005453-4057qib7 3007 21 start start NN cord-005453-4057qib7 3007 22 of of IN cord-005453-4057qib7 3007 23 treatment treatment NN cord-005453-4057qib7 3007 24 with with IN cord-005453-4057qib7 3007 25 conditioning conditioning NN cord-005453-4057qib7 3007 26 chemotherapy chemotherapy NN cord-005453-4057qib7 3007 27 , , , cord-005453-4057qib7 3007 28 defined define VBN cord-005453-4057qib7 3007 29 as as IN cord-005453-4057qib7 3007 30 baseline baseline NN cord-005453-4057qib7 3007 31 ( ( -LRB- cord-005453-4057qib7 3007 32 615 615 CD cord-005453-4057qib7 3007 33 ng ng NN cord-005453-4057qib7 3007 34 / / SYM cord-005453-4057qib7 3007 35 ml ml NN cord-005453-4057qib7 3008 1 ( ( -LRB- cord-005453-4057qib7 3008 2 quartiles quartiles NNP cord-005453-4057qib7 3008 3 441 441 CD cord-005453-4057qib7 3008 4 - - HYPH cord-005453-4057qib7 3008 5 1132 1132 CD cord-005453-4057qib7 3008 6 ) ) -RRB- cord-005453-4057qib7 3008 7 at at IN cord-005453-4057qib7 3008 8 day day NN cord-005453-4057qib7 3008 9 0 0 CD cord-005453-4057qib7 3008 10 vs vs IN cord-005453-4057qib7 3008 11 771 771 CD cord-005453-4057qib7 3008 12 ng ng NNP cord-005453-4057qib7 3008 13 / / SYM cord-005453-4057qib7 3008 14 ml ml NN cord-005453-4057qib7 3008 15 ( ( -LRB- cord-005453-4057qib7 3008 16 542 542 CD cord-005453-4057qib7 3008 17 - - HYPH cord-005453-4057qib7 3008 18 1348 1348 CD cord-005453-4057qib7 3008 19 ) ) -RRB- cord-005453-4057qib7 3008 20 at at IN cord-005453-4057qib7 3008 21 baseline baseline NN cord-005453-4057qib7 3008 22 , , , cord-005453-4057qib7 3008 23 p p NN cord-005453-4057qib7 3008 24 < < XX cord-005453-4057qib7 3008 25 0.01 0.01 CD cord-005453-4057qib7 3008 26 ) ) -RRB- cord-005453-4057qib7 3008 27 . . . cord-005453-4057qib7 3009 1 From from IN cord-005453-4057qib7 3009 2 day day NN cord-005453-4057qib7 3009 3 +7 +7 CD cord-005453-4057qib7 3009 4 SP sp NN cord-005453-4057qib7 3009 5 - - HYPH cord-005453-4057qib7 3009 6 D d JJ cord-005453-4057qib7 3009 7 levels level NNS cord-005453-4057qib7 3009 8 increased increase VBD cord-005453-4057qib7 3009 9 and and CC cord-005453-4057qib7 3009 10 remained remain VBD cord-005453-4057qib7 3009 11 increased increase VBN cord-005453-4057qib7 3009 12 during during IN cord-005453-4057qib7 3009 13 the the DT cord-005453-4057qib7 3009 14 whole whole JJ cord-005453-4057qib7 3009 15 study study NN cord-005453-4057qib7 3009 16 period period NN cord-005453-4057qib7 3009 17 ( ( -LRB- cord-005453-4057qib7 3009 18 771 771 CD cord-005453-4057qib7 3009 19 ng ng NN cord-005453-4057qib7 3009 20 / / SYM cord-005453-4057qib7 3009 21 ml ml NN cord-005453-4057qib7 3009 22 ( ( -LRB- cord-005453-4057qib7 3009 23 542 542 CD cord-005453-4057qib7 3009 24 - - HYPH cord-005453-4057qib7 3009 25 1348 1348 CD cord-005453-4057qib7 3009 26 ) ) -RRB- cord-005453-4057qib7 3009 27 at at IN cord-005453-4057qib7 3009 28 baseline baseline NN cord-005453-4057qib7 3009 29 vs vs IN cord-005453-4057qib7 3009 30 1287 1287 CD cord-005453-4057qib7 3009 31 ng ng NNP cord-005453-4057qib7 3009 32 / / SYM cord-005453-4057qib7 3009 33 ml ml NN cord-005453-4057qib7 3009 34 ( ( -LRB- cord-005453-4057qib7 3009 35 713 713 CD cord-005453-4057qib7 3009 36 - - HYPH cord-005453-4057qib7 3009 37 2549 2549 CD cord-005453-4057qib7 3009 38 ) ) -RRB- cord-005453-4057qib7 3009 39 at at IN cord-005453-4057qib7 3009 40 6 6 CD cord-005453-4057qib7 3009 41 months month NNS cord-005453-4057qib7 3009 42 , , , cord-005453-4057qib7 3009 43 p p NN cord-005453-4057qib7 3009 44 < < XX cord-005453-4057qib7 3009 45 0.01 0.01 CD cord-005453-4057qib7 3009 46 ) ) -RRB- cord-005453-4057qib7 3009 47 . . . cord-005453-4057qib7 3010 1 Acute acute JJ cord-005453-4057qib7 3010 2 GvHD GvHD NNP cord-005453-4057qib7 3010 3 ( ( -LRB- cord-005453-4057qib7 3010 4 aGvHD agvhd NN cord-005453-4057qib7 3010 5 ) ) -RRB- cord-005453-4057qib7 3010 6 occurred occur VBD cord-005453-4057qib7 3010 7 in in IN cord-005453-4057qib7 3010 8 25 25 CD cord-005453-4057qib7 3010 9 patients patient NNS cord-005453-4057qib7 3010 10 , , , cord-005453-4057qib7 3010 11 of of IN cord-005453-4057qib7 3010 12 those those DT cord-005453-4057qib7 3010 13 17 17 CD cord-005453-4057qib7 3010 14 patients patient NNS cord-005453-4057qib7 3010 15 with with IN cord-005453-4057qib7 3010 16 grade grade NN cord-005453-4057qib7 3010 17 2 2 CD cord-005453-4057qib7 3010 18 - - SYM cord-005453-4057qib7 3010 19 4 4 CD cord-005453-4057qib7 3010 20 . . . cord-005453-4057qib7 3011 1 High high JJ cord-005453-4057qib7 3011 2 SP sp NN cord-005453-4057qib7 3011 3 - - HYPH cord-005453-4057qib7 3011 4 D d JJ cord-005453-4057qib7 3011 5 levels level NNS cord-005453-4057qib7 3011 6 at at IN cord-005453-4057qib7 3011 7 day day NN cord-005453-4057qib7 3011 8 +14 +14 CD cord-005453-4057qib7 3011 9 were be VBD cord-005453-4057qib7 3011 10 associated associate VBN cord-005453-4057qib7 3011 11 with with IN cord-005453-4057qib7 3011 12 the the DT cord-005453-4057qib7 3011 13 development development NN cord-005453-4057qib7 3011 14 of of IN cord-005453-4057qib7 3011 15 aGvHD agvhd NN cord-005453-4057qib7 3011 16 ( ( -LRB- cord-005453-4057qib7 3011 17 1402 1402 CD cord-005453-4057qib7 3011 18 ng ng NN cord-005453-4057qib7 3011 19 / / SYM cord-005453-4057qib7 3011 20 ml ml NN cord-005453-4057qib7 3011 21 ( ( -LRB- cord-005453-4057qib7 3011 22 1244 1244 CD cord-005453-4057qib7 3011 23 - - SYM cord-005453-4057qib7 3011 24 2023 2023 CD cord-005453-4057qib7 3011 25 ) ) -RRB- cord-005453-4057qib7 3011 26 vs vs IN cord-005453-4057qib7 3011 27 839 839 CD cord-005453-4057qib7 3011 28 ng ng NN cord-005453-4057qib7 3011 29 / / SYM cord-005453-4057qib7 3011 30 ml ml NN cord-005453-4057qib7 3011 31 ( ( -LRB- cord-005453-4057qib7 3011 32 523 523 CD cord-005453-4057qib7 3011 33 - - SYM cord-005453-4057qib7 3011 34 1630 1630 CD cord-005453-4057qib7 3011 35 ) ) -RRB- cord-005453-4057qib7 3011 36 , , , cord-005453-4057qib7 3011 37 p p NN cord-005453-4057qib7 3011 38 < < XX cord-005453-4057qib7 3011 39 0.01 0.01 CD cord-005453-4057qib7 3011 40 ) ) -RRB- cord-005453-4057qib7 3011 41 ( ( -LRB- cord-005453-4057qib7 3011 42 fig fig NN cord-005453-4057qib7 3011 43 . . NNP cord-005453-4057qib7 3011 44 1 1 CD cord-005453-4057qib7 3011 45 ) ) -RRB- cord-005453-4057qib7 3011 46 . . . cord-005453-4057qib7 3012 1 The the DT cord-005453-4057qib7 3012 2 C C NNP cord-005453-4057qib7 3012 3 / / SYM cord-005453-4057qib7 3012 4 C c NN cord-005453-4057qib7 3012 5 genotype genotype NN cord-005453-4057qib7 3012 6 was be VBD cord-005453-4057qib7 3012 7 associated associate VBN cord-005453-4057qib7 3012 8 with with IN cord-005453-4057qib7 3012 9 generally generally RB cord-005453-4057qib7 3012 10 low low JJ cord-005453-4057qib7 3012 11 SP sp NN cord-005453-4057qib7 3012 12 - - HYPH cord-005453-4057qib7 3012 13 D d JJ cord-005453-4057qib7 3012 14 levels level NNS cord-005453-4057qib7 3012 15 and and CC cord-005453-4057qib7 3012 16 low low JJ cord-005453-4057qib7 3012 17 FEV1 FEV1 NNP cord-005453-4057qib7 3012 18 / / SYM cord-005453-4057qib7 3012 19 FVC FVC NNP cord-005453-4057qib7 3012 20 at at RB cord-005453-4057qib7 3012 21 all all DT cord-005453-4057qib7 3012 22 time time NN cord-005453-4057qib7 3012 23 intervals interval NNS cord-005453-4057qib7 3012 24 compared compare VBN cord-005453-4057qib7 3012 25 to to IN cord-005453-4057qib7 3012 26 the the DT cord-005453-4057qib7 3012 27 other other JJ cord-005453-4057qib7 3012 28 genotypes genotype NNS cord-005453-4057qib7 3012 29 , , , cord-005453-4057qib7 3012 30 significantly significantly RB cord-005453-4057qib7 3012 31 24 24 CD cord-005453-4057qib7 3012 32 - - SYM cord-005453-4057qib7 3012 33 36 36 CD cord-005453-4057qib7 3012 34 months month NNS cord-005453-4057qib7 3012 35 post post NN cord-005453-4057qib7 3012 36 - - JJ cord-005453-4057qib7 3012 37 HSCT hsct JJ cord-005453-4057qib7 3012 38 ( ( -LRB- cord-005453-4057qib7 3012 39 p=0.02 p=0.02 NNP cord-005453-4057qib7 3012 40 ) ) -RRB- cord-005453-4057qib7 3012 41 . . . cord-005453-4057qib7 3013 1 There there EX cord-005453-4057qib7 3013 2 was be VBD cord-005453-4057qib7 3013 3 no no DT cord-005453-4057qib7 3013 4 overall overall JJ cord-005453-4057qib7 3013 5 correlation correlation NN cord-005453-4057qib7 3013 6 between between IN cord-005453-4057qib7 3013 7 SP SP NNP cord-005453-4057qib7 3013 8 - - HYPH cord-005453-4057qib7 3013 9 D d JJ cord-005453-4057qib7 3013 10 levels level NNS cord-005453-4057qib7 3013 11 and and CC cord-005453-4057qib7 3013 12 lung lung NN cord-005453-4057qib7 3013 13 function function NN cord-005453-4057qib7 3013 14 , , , cord-005453-4057qib7 3013 15 but but CC cord-005453-4057qib7 3013 16 stratifying stratify VBG cord-005453-4057qib7 3013 17 for for IN cord-005453-4057qib7 3013 18 genotype genotype NN cord-005453-4057qib7 3013 19 , , , cord-005453-4057qib7 3013 20 high high JJ cord-005453-4057qib7 3013 21 baseline baseline JJ cord-005453-4057qib7 3013 22 SP sp NN cord-005453-4057qib7 3013 23 - - HYPH cord-005453-4057qib7 3013 24 D d JJ cord-005453-4057qib7 3013 25 levels level NNS cord-005453-4057qib7 3013 26 were be VBD cord-005453-4057qib7 3013 27 predictive predictive JJ cord-005453-4057qib7 3013 28 for for IN cord-005453-4057qib7 3013 29 reduced reduced JJ cord-005453-4057qib7 3013 30 FEV1 FEV1 NNP cord-005453-4057qib7 3013 31 / / SYM cord-005453-4057qib7 3013 32 FVC FVC NNP cord-005453-4057qib7 3013 33 at at IN cord-005453-4057qib7 3013 34 8 8 CD cord-005453-4057qib7 3013 35 - - SYM cord-005453-4057qib7 3013 36 24 24 CD cord-005453-4057qib7 3013 37 months month NNS cord-005453-4057qib7 3013 38 in in IN cord-005453-4057qib7 3013 39 CC CC NNP cord-005453-4057qib7 3013 40 and and CC cord-005453-4057qib7 3013 41 TT TT NNP cord-005453-4057qib7 3013 42 homozygous homozygous JJ cord-005453-4057qib7 3013 43 individuals individual NNS cord-005453-4057qib7 3013 44 . . . cord-005453-4057qib7 3014 1 Conclusions conclusion NNS cord-005453-4057qib7 3014 2 : : : cord-005453-4057qib7 3015 1 Patients patient NNS cord-005453-4057qib7 3015 2 with with IN cord-005453-4057qib7 3015 3 a a DT cord-005453-4057qib7 3015 4 genotype genotype NN cord-005453-4057qib7 3015 5 causing cause VBG cord-005453-4057qib7 3015 6 low low JJ cord-005453-4057qib7 3015 7 capacity capacity NN cord-005453-4057qib7 3015 8 for for IN cord-005453-4057qib7 3015 9 SP SP NNP cord-005453-4057qib7 3015 10 - - HYPH cord-005453-4057qib7 3015 11 D d JJ cord-005453-4057qib7 3015 12 production production NN cord-005453-4057qib7 3015 13 are be VBP cord-005453-4057qib7 3015 14 at at IN cord-005453-4057qib7 3015 15 increased increase VBN cord-005453-4057qib7 3015 16 risk risk NN cord-005453-4057qib7 3015 17 of of IN cord-005453-4057qib7 3015 18 developing develop VBG cord-005453-4057qib7 3015 19 pulmonary pulmonary JJ cord-005453-4057qib7 3015 20 impairment impairment NN cord-005453-4057qib7 3015 21 after after IN cord-005453-4057qib7 3015 22 HSCT HSCT NNP cord-005453-4057qib7 3015 23 . . . cord-005453-4057qib7 3016 1 In in IN cord-005453-4057qib7 3016 2 addition addition NN cord-005453-4057qib7 3016 3 , , , cord-005453-4057qib7 3016 4 our -PRON- PRP$ cord-005453-4057qib7 3016 5 data datum NNS cord-005453-4057qib7 3016 6 lend lend VBP cord-005453-4057qib7 3016 7 support support NN cord-005453-4057qib7 3016 8 to to IN cord-005453-4057qib7 3016 9 other other JJ cord-005453-4057qib7 3016 10 studies study NNS cord-005453-4057qib7 3016 11 indicating indicate VBG cord-005453-4057qib7 3016 12 that that IN cord-005453-4057qib7 3016 13 SPD SPD NNP cord-005453-4057qib7 3016 14 production production NN cord-005453-4057qib7 3016 15 may may MD cord-005453-4057qib7 3016 16 increase increase VB cord-005453-4057qib7 3016 17 during during IN cord-005453-4057qib7 3016 18 inflammatory inflammatory JJ cord-005453-4057qib7 3016 19 pulmonary pulmonary JJ cord-005453-4057qib7 3016 20 disease disease NN cord-005453-4057qib7 3016 21 , , , cord-005453-4057qib7 3016 22 acting act VBG cord-005453-4057qib7 3016 23 as as IN cord-005453-4057qib7 3016 24 a a DT cord-005453-4057qib7 3016 25 reactive reactive JJ cord-005453-4057qib7 3016 26 , , , cord-005453-4057qib7 3016 27 protective protective JJ cord-005453-4057qib7 3016 28 mechanism mechanism NN cord-005453-4057qib7 3016 29 . . . cord-005453-4057qib7 3017 1 Further further JJ cord-005453-4057qib7 3017 2 research research NN cord-005453-4057qib7 3017 3 is be VBZ cord-005453-4057qib7 3017 4 warranted warrant VBN cord-005453-4057qib7 3017 5 to to TO cord-005453-4057qib7 3017 6 define define VB cord-005453-4057qib7 3017 7 the the DT cord-005453-4057qib7 3017 8 role role NN cord-005453-4057qib7 3017 9 of of IN cord-005453-4057qib7 3017 10 SP SP NNP cord-005453-4057qib7 3017 11 - - HYPH cord-005453-4057qib7 3017 12 D d JJ cord-005453-4057qib7 3017 13 levels level NNS cord-005453-4057qib7 3017 14 and and CC cord-005453-4057qib7 3017 15 genotypes genotype NNS cord-005453-4057qib7 3017 16 as as IN cord-005453-4057qib7 3017 17 a a DT cord-005453-4057qib7 3017 18 prognostic prognostic JJ cord-005453-4057qib7 3017 19 tool tool NN cord-005453-4057qib7 3017 20 for for IN cord-005453-4057qib7 3017 21 lung lung NN cord-005453-4057qib7 3017 22 function function NN cord-005453-4057qib7 3017 23 and and CC cord-005453-4057qib7 3017 24 aGvHD agvhd NN cord-005453-4057qib7 3017 25 . . . cord-005453-4057qib7 3018 1 [ [ -LRB- cord-005453-4057qib7 3018 2 [ [ -LRB- cord-005453-4057qib7 3018 3 P147 P147 NNP cord-005453-4057qib7 3018 4 Image image NN cord-005453-4057qib7 3018 5 ] ] -RRB- cord-005453-4057qib7 3018 6 1 1 CD cord-005453-4057qib7 3018 7 . . . cord-005453-4057qib7 3019 1 Background background NN cord-005453-4057qib7 3019 2 : : : cord-005453-4057qib7 3020 1 Allogeneic allogeneic IN cord-005453-4057qib7 3020 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 3020 3 cell cell NN cord-005453-4057qib7 3020 4 transplantation transplantation NN cord-005453-4057qib7 3020 5 ( ( -LRB- cord-005453-4057qib7 3020 6 alloHCT alloHCT NNP cord-005453-4057qib7 3020 7 ) ) -RRB- cord-005453-4057qib7 3020 8 means mean VBZ cord-005453-4057qib7 3020 9 a a DT cord-005453-4057qib7 3020 10 long long JJ cord-005453-4057qib7 3020 11 period period NN cord-005453-4057qib7 3020 12 of of IN cord-005453-4057qib7 3020 13 restricted restricted JJ cord-005453-4057qib7 3020 14 mobility mobility NN cord-005453-4057qib7 3020 15 and and CC cord-005453-4057qib7 3020 16 a a DT cord-005453-4057qib7 3020 17 range range NN cord-005453-4057qib7 3020 18 of of IN cord-005453-4057qib7 3020 19 therapy therapy NN cord-005453-4057qib7 3020 20 related relate VBN cord-005453-4057qib7 3020 21 side side NN cord-005453-4057qib7 3020 22 effects effect NNS cord-005453-4057qib7 3020 23 on on IN cord-005453-4057qib7 3020 24 muscle muscle NN cord-005453-4057qib7 3020 25 function function NN cord-005453-4057qib7 3020 26 . . . cord-005453-4057qib7 3021 1 In in IN cord-005453-4057qib7 3021 2 this this DT cord-005453-4057qib7 3021 3 context context NN cord-005453-4057qib7 3021 4 patients patient NNS cord-005453-4057qib7 3021 5 demonstrated demonstrate VBD cord-005453-4057qib7 3021 6 a a DT cord-005453-4057qib7 3021 7 huge huge JJ cord-005453-4057qib7 3021 8 decline decline NN cord-005453-4057qib7 3021 9 of of IN cord-005453-4057qib7 3021 10 physical physical JJ cord-005453-4057qib7 3021 11 capacity capacity NN cord-005453-4057qib7 3021 12 and and CC cord-005453-4057qib7 3021 13 muscle muscle NN cord-005453-4057qib7 3021 14 mass mass NN cord-005453-4057qib7 3021 15 in in IN cord-005453-4057qib7 3021 16 particular particular JJ cord-005453-4057qib7 3021 17 , , , cord-005453-4057qib7 3021 18 accompanied accompany VBN cord-005453-4057qib7 3021 19 with with IN cord-005453-4057qib7 3021 20 a a DT cord-005453-4057qib7 3021 21 decrease decrease NN cord-005453-4057qib7 3021 22 of of IN cord-005453-4057qib7 3021 23 quality quality NN cord-005453-4057qib7 3021 24 of of IN cord-005453-4057qib7 3021 25 life life NN cord-005453-4057qib7 3021 26 ( ( -LRB- cord-005453-4057qib7 3021 27 QoL qol NN cord-005453-4057qib7 3021 28 ) ) -RRB- cord-005453-4057qib7 3021 29 . . . cord-005453-4057qib7 3022 1 Resistance resistance NN cord-005453-4057qib7 3022 2 training training NN cord-005453-4057qib7 3022 3 could could MD cord-005453-4057qib7 3022 4 maintain maintain VB cord-005453-4057qib7 3022 5 muscle muscle NN cord-005453-4057qib7 3022 6 mass mass NN cord-005453-4057qib7 3022 7 but but CC cord-005453-4057qib7 3022 8 is be VBZ cord-005453-4057qib7 3022 9 limited limit VBN cord-005453-4057qib7 3022 10 by by IN cord-005453-4057qib7 3022 11 patientsb patientsb NNP cord-005453-4057qib7 3022 12 lood lood NNP cord-005453-4057qib7 3022 13 values value NNS cord-005453-4057qib7 3022 14 ( ( -LRB- cord-005453-4057qib7 3022 15 platelet platelet NN cord-005453-4057qib7 3022 16 - - HYPH cord-005453-4057qib7 3022 17 count count NN cord-005453-4057qib7 3022 18 ) ) -RRB- cord-005453-4057qib7 3022 19 and and CC cord-005453-4057qib7 3022 20 well well RB cord-005453-4057qib7 3022 21 - - HYPH cord-005453-4057qib7 3022 22 being being NN cord-005453-4057qib7 3022 23 . . . cord-005453-4057qib7 3023 1 Whole whole JJ cord-005453-4057qib7 3023 2 body body NN cord-005453-4057qib7 3023 3 vibration vibration NN cord-005453-4057qib7 3023 4 ( ( -LRB- cord-005453-4057qib7 3023 5 WBV wbv NN cord-005453-4057qib7 3023 6 ) ) -RRB- cord-005453-4057qib7 3023 7 was be VBD cord-005453-4057qib7 3023 8 shown show VBN cord-005453-4057qib7 3023 9 to to TO cord-005453-4057qib7 3023 10 maintain maintain VB cord-005453-4057qib7 3023 11 muscle muscle NN cord-005453-4057qib7 3023 12 mass mass NN cord-005453-4057qib7 3023 13 during during IN cord-005453-4057qib7 3023 14 bed bed NN cord-005453-4057qib7 3023 15 rest rest NN cord-005453-4057qib7 3023 16 and and CC cord-005453-4057qib7 3023 17 has have VBZ cord-005453-4057qib7 3023 18 less less JJR cord-005453-4057qib7 3023 19 impact impact NN cord-005453-4057qib7 3023 20 on on IN cord-005453-4057qib7 3023 21 blood blood NN cord-005453-4057qib7 3023 22 pressure pressure NN cord-005453-4057qib7 3023 23 than than IN cord-005453-4057qib7 3023 24 conventional conventional JJ cord-005453-4057qib7 3023 25 resistance resistance NN cord-005453-4057qib7 3023 26 exercises exercise NNS cord-005453-4057qib7 3023 27 . . . cord-005453-4057qib7 3024 1 Furthermore furthermore RB cord-005453-4057qib7 3024 2 it -PRON- PRP cord-005453-4057qib7 3024 3 was be VBD cord-005453-4057qib7 3024 4 also also RB cord-005453-4057qib7 3024 5 shown show VBN cord-005453-4057qib7 3024 6 to to TO cord-005453-4057qib7 3024 7 be be VB cord-005453-4057qib7 3024 8 feasible feasible JJ cord-005453-4057qib7 3024 9 in in IN cord-005453-4057qib7 3024 10 patients patient NNS cord-005453-4057qib7 3024 11 during during IN cord-005453-4057qib7 3024 12 high high JJ cord-005453-4057qib7 3024 13 dose dose NN cord-005453-4057qib7 3024 14 chemotherapy chemotherapy NN cord-005453-4057qib7 3024 15 . . . cord-005453-4057qib7 3025 1 Therefore therefore RB cord-005453-4057qib7 3025 2 the the DT cord-005453-4057qib7 3025 3 aim aim NN cord-005453-4057qib7 3025 4 of of IN cord-005453-4057qib7 3025 5 our -PRON- PRP$ cord-005453-4057qib7 3025 6 study study NN cord-005453-4057qib7 3025 7 was be VBD cord-005453-4057qib7 3025 8 to to TO cord-005453-4057qib7 3025 9 examine examine VB cord-005453-4057qib7 3025 10 the the DT cord-005453-4057qib7 3025 11 effects effect NNS cord-005453-4057qib7 3025 12 of of IN cord-005453-4057qib7 3025 13 WBV WBV NNP cord-005453-4057qib7 3025 14 during during IN cord-005453-4057qib7 3025 15 alloHCT alloHCT NNP cord-005453-4057qib7 3025 16 on on IN cord-005453-4057qib7 3025 17 patients patient NNS cord-005453-4057qib7 3025 18 physical physical JJ cord-005453-4057qib7 3025 19 and and CC cord-005453-4057qib7 3025 20 functional functional JJ cord-005453-4057qib7 3025 21 performance performance NN cord-005453-4057qib7 3025 22 as as RB cord-005453-4057qib7 3025 23 well well RB cord-005453-4057qib7 3025 24 as as IN cord-005453-4057qib7 3025 25 QoL. QoL. NNP cord-005453-4057qib7 3025 26 Methods Methods NNPS cord-005453-4057qib7 3025 27 : : : cord-005453-4057qib7 3025 28 43 43 CD cord-005453-4057qib7 3025 29 patients patient NNS cord-005453-4057qib7 3025 30 receiving receive VBG cord-005453-4057qib7 3025 31 alloHCT alloHCT NNP cord-005453-4057qib7 3025 32 were be VBD cord-005453-4057qib7 3025 33 randomly randomly RB cord-005453-4057qib7 3025 34 allocated allocate VBN cord-005453-4057qib7 3025 35 to to IN cord-005453-4057qib7 3025 36 either either CC cord-005453-4057qib7 3025 37 a a DT cord-005453-4057qib7 3025 38 WBV WBV NNP cord-005453-4057qib7 3025 39 exercise exercise NN cord-005453-4057qib7 3025 40 group group NN cord-005453-4057qib7 3025 41 ( ( -LRB- cord-005453-4057qib7 3025 42 IG IG NNP cord-005453-4057qib7 3025 43 ) ) -RRB- cord-005453-4057qib7 3025 44 or or CC cord-005453-4057qib7 3025 45 an an DT cord-005453-4057qib7 3025 46 active active JJ cord-005453-4057qib7 3025 47 control control NN cord-005453-4057qib7 3025 48 group group NN cord-005453-4057qib7 3025 49 ( ( -LRB- cord-005453-4057qib7 3025 50 CG CG NNP cord-005453-4057qib7 3025 51 ) ) -RRB- cord-005453-4057qib7 3025 52 doing do VBG cord-005453-4057qib7 3025 53 stretching stretching NN cord-005453-4057qib7 3025 54 and and CC cord-005453-4057qib7 3025 55 mobilization mobilization NN cord-005453-4057qib7 3025 56 . . . cord-005453-4057qib7 3026 1 Both both DT cord-005453-4057qib7 3026 2 groups group NNS cord-005453-4057qib7 3026 3 exercised exercise VBD cord-005453-4057qib7 3026 4 during during IN cord-005453-4057qib7 3026 5 the the DT cord-005453-4057qib7 3026 6 whole whole JJ cord-005453-4057qib7 3026 7 time time NN cord-005453-4057qib7 3026 8 of of IN cord-005453-4057qib7 3026 9 hospitalization hospitalization NN cord-005453-4057qib7 3026 10 for for IN cord-005453-4057qib7 3026 11 5 5 CD cord-005453-4057qib7 3026 12 times time NNS cord-005453-4057qib7 3026 13 per per IN cord-005453-4057qib7 3026 14 week week NN cord-005453-4057qib7 3026 15 and and CC cord-005453-4057qib7 3026 16 underwent undergo VBD cord-005453-4057qib7 3026 17 pre- pre- JJ cord-005453-4057qib7 3026 18 , , , cord-005453-4057qib7 3026 19 post post JJ cord-005453-4057qib7 3026 20 - - JJ cord-005453-4057qib7 3026 21 and and CC cord-005453-4057qib7 3026 22 followup followup JJ cord-005453-4057qib7 3026 23 - - HYPH cord-005453-4057qib7 3026 24 assessment assessment NN cord-005453-4057qib7 3026 25 . . . cord-005453-4057qib7 3027 1 Physical physical JJ cord-005453-4057qib7 3027 2 capacity capacity NN cord-005453-4057qib7 3027 3 was be VBD cord-005453-4057qib7 3027 4 determined determine VBN cord-005453-4057qib7 3027 5 by by IN cord-005453-4057qib7 3027 6 maximum maximum JJ cord-005453-4057qib7 3027 7 oxygen oxygen NN cord-005453-4057qib7 3027 8 consumption consumption NN cord-005453-4057qib7 3027 9 ( ( -LRB- cord-005453-4057qib7 3027 10 VO VO NNP cord-005453-4057qib7 3027 11 2peak 2peak CD cord-005453-4057qib7 3027 12 ) ) -RRB- cord-005453-4057qib7 3027 13 and and CC cord-005453-4057qib7 3027 14 maximum maximum JJ cord-005453-4057qib7 3027 15 power power NN cord-005453-4057qib7 3027 16 ( ( -LRB- cord-005453-4057qib7 3027 17 P p NN cord-005453-4057qib7 3027 18 max max NN cord-005453-4057qib7 3027 19 ) ) -RRB- cord-005453-4057qib7 3027 20 during during IN cord-005453-4057qib7 3027 21 cardiorespiratory cardiorespiratory JJ cord-005453-4057qib7 3027 22 exercise exercise NN cord-005453-4057qib7 3027 23 test test NN cord-005453-4057qib7 3027 24 and and CC cord-005453-4057qib7 3027 25 by by IN cord-005453-4057qib7 3027 26 maximum maximum JJ cord-005453-4057qib7 3027 27 strength strength NN cord-005453-4057qib7 3027 28 of of IN cord-005453-4057qib7 3027 29 the the DT cord-005453-4057qib7 3027 30 knee knee NN cord-005453-4057qib7 3027 31 extensors extensor NNS cord-005453-4057qib7 3027 32 and and CC cord-005453-4057qib7 3027 33 flexors flexor NNS cord-005453-4057qib7 3027 34 ( ( -LRB- cord-005453-4057qib7 3027 35 EX EX NNP cord-005453-4057qib7 3027 36 max max NN cord-005453-4057qib7 3027 37 , , , cord-005453-4057qib7 3027 38 FLEX FLEX NNP cord-005453-4057qib7 3027 39 max max NNP cord-005453-4057qib7 3027 40 ) ) -RRB- cord-005453-4057qib7 3027 41 during during IN cord-005453-4057qib7 3027 42 isokinetic isokinetic JJ cord-005453-4057qib7 3027 43 strength strength NN cord-005453-4057qib7 3027 44 test test NN cord-005453-4057qib7 3027 45 . . . cord-005453-4057qib7 3028 1 Functional functional JJ cord-005453-4057qib7 3028 2 performance performance NN cord-005453-4057qib7 3028 3 was be VBD cord-005453-4057qib7 3028 4 assessed assess VBN cord-005453-4057qib7 3028 5 by by IN cord-005453-4057qib7 3028 6 jumping jump VBG cord-005453-4057qib7 3028 7 height height NN cord-005453-4057qib7 3028 8 during during IN cord-005453-4057qib7 3028 9 counter counter JJ cord-005453-4057qib7 3028 10 movement movement NN cord-005453-4057qib7 3028 11 jump jump NN cord-005453-4057qib7 3028 12 ( ( -LRB- cord-005453-4057qib7 3028 13 CMJ CMJ NNP cord-005453-4057qib7 3028 14 ) ) -RRB- cord-005453-4057qib7 3028 15 and and CC cord-005453-4057qib7 3028 16 time time NN cord-005453-4057qib7 3028 17 of of IN cord-005453-4057qib7 3028 18 chair chair NN cord-005453-4057qib7 3028 19 rising rise VBG cord-005453-4057qib7 3028 20 test test NN cord-005453-4057qib7 3028 21 ( ( -LRB- cord-005453-4057qib7 3028 22 CRT CRT NNP cord-005453-4057qib7 3028 23 ) ) -RRB- cord-005453-4057qib7 3028 24 as as RB cord-005453-4057qib7 3028 25 well well RB cord-005453-4057qib7 3028 26 as as IN cord-005453-4057qib7 3028 27 power power NN cord-005453-4057qib7 3028 28 output output NN cord-005453-4057qib7 3028 29 during during IN cord-005453-4057qib7 3028 30 both both DT cord-005453-4057qib7 3028 31 tests test NNS cord-005453-4057qib7 3028 32 . . . cord-005453-4057qib7 3029 1 QoL QoL NNP cord-005453-4057qib7 3029 2 was be VBD cord-005453-4057qib7 3029 3 assessed assess VBN cord-005453-4057qib7 3029 4 by by IN cord-005453-4057qib7 3029 5 questionnaires questionnaire NNS cord-005453-4057qib7 3029 6 of of IN cord-005453-4057qib7 3029 7 the the DT cord-005453-4057qib7 3029 8 EORTC EORTC NNP cord-005453-4057qib7 3029 9 . . . cord-005453-4057qib7 3030 1 Results result NNS cord-005453-4057qib7 3030 2 : : : cord-005453-4057qib7 3031 1 During during IN cord-005453-4057qib7 3031 2 alloHSCT alloHSCT NNP cord-005453-4057qib7 3031 3 VO VO NNP cord-005453-4057qib7 3031 4 2peak 2peak CD cord-005453-4057qib7 3031 5 and and CC cord-005453-4057qib7 3031 6 P P NNP cord-005453-4057qib7 3031 7 max max NN cord-005453-4057qib7 3031 8 decreased decrease VBD cord-005453-4057qib7 3031 9 in in IN cord-005453-4057qib7 3031 10 both both DT cord-005453-4057qib7 3031 11 groups group NNS cord-005453-4057qib7 3031 12 but but CC cord-005453-4057qib7 3031 13 till till IN cord-005453-4057qib7 3031 14 follow follow NN cord-005453-4057qib7 3031 15 - - HYPH cord-005453-4057qib7 3031 16 up up RP cord-005453-4057qib7 3031 17 an an DT cord-005453-4057qib7 3031 18 increase increase NN cord-005453-4057qib7 3031 19 is be VBZ cord-005453-4057qib7 3031 20 seen see VBN cord-005453-4057qib7 3031 21 in in IN cord-005453-4057qib7 3031 22 the the DT cord-005453-4057qib7 3031 23 IG ig NN cord-005453-4057qib7 3031 24 ( ( -LRB- cord-005453-4057qib7 3031 25 P=0.035 p=0.035 NN cord-005453-4057qib7 3031 26 ; ; : cord-005453-4057qib7 3031 27 P=0.011 P=0.011 NNP cord-005453-4057qib7 3031 28 ) ) -RRB- cord-005453-4057qib7 3031 29 . . . cord-005453-4057qib7 3032 1 At at IN cord-005453-4057qib7 3032 2 day day NN cord-005453-4057qib7 3032 3 +180 +180 NNP cord-005453-4057qib7 3032 4 / / CC cord-005453-4057qib7 3032 5 follow follow NN cord-005453-4057qib7 3032 6 - - HYPH cord-005453-4057qib7 3032 7 up up NN cord-005453-4057qib7 3032 8 a a DT cord-005453-4057qib7 3032 9 VO VO NNP cord-005453-4057qib7 3032 10 2peak 2peak CD cord-005453-4057qib7 3032 11 group group NN cord-005453-4057qib7 3032 12 difference difference NN cord-005453-4057qib7 3032 13 is be VBZ cord-005453-4057qib7 3032 14 seen see VBN cord-005453-4057qib7 3032 15 ( ( -LRB- cord-005453-4057qib7 3032 16 P=0.034 P=0.034 NNP cord-005453-4057qib7 3032 17 ) ) -RRB- cord-005453-4057qib7 3032 18 . . . cord-005453-4057qib7 3033 1 EX EX NNP cord-005453-4057qib7 3033 2 max max NNP cord-005453-4057qib7 3033 3 ( ( -LRB- cord-005453-4057qib7 3033 4 P=0.003 P=0.003 NNP cord-005453-4057qib7 3033 5 ) ) -RRB- cord-005453-4057qib7 3033 6 and and CC cord-005453-4057qib7 3033 7 FLEX FLEX NNP cord-005453-4057qib7 3033 8 max max NNP cord-005453-4057qib7 3033 9 ( ( -LRB- cord-005453-4057qib7 3033 10 P=0.044 P=0.044 NNP cord-005453-4057qib7 3033 11 ) ) -RRB- cord-005453-4057qib7 3033 12 were be VBD cord-005453-4057qib7 3033 13 only only RB cord-005453-4057qib7 3033 14 reduced reduce VBN cord-005453-4057qib7 3033 15 in in IN cord-005453-4057qib7 3033 16 the the DT cord-005453-4057qib7 3033 17 CG CG NNP cord-005453-4057qib7 3033 18 during during IN cord-005453-4057qib7 3033 19 hospitalization hospitalization NN cord-005453-4057qib7 3033 20 . . . cord-005453-4057qib7 3034 1 Jumping jump VBG cord-005453-4057qib7 3034 2 height height NN cord-005453-4057qib7 3034 3 and and CC cord-005453-4057qib7 3034 4 power power NN cord-005453-4057qib7 3034 5 output output NN cord-005453-4057qib7 3034 6 decreased decrease VBD cord-005453-4057qib7 3034 7 in in IN cord-005453-4057qib7 3034 8 the the DT cord-005453-4057qib7 3034 9 CG CG NNP cord-005453-4057qib7 3034 10 during during IN cord-005453-4057qib7 3034 11 hospitalization hospitalization NN cord-005453-4057qib7 3034 12 ( ( -LRB- cord-005453-4057qib7 3034 13 P=0.005 P=0.005 NNP cord-005453-4057qib7 3034 14 , , , cord-005453-4057qib7 3034 15 P=0.039 P=0.039 NNP cord-005453-4057qib7 3034 16 ) ) -RRB- cord-005453-4057qib7 3034 17 and and CC cord-005453-4057qib7 3034 18 a a DT cord-005453-4057qib7 3034 19 difference difference NN cord-005453-4057qib7 3034 20 between between IN cord-005453-4057qib7 3034 21 groups group NNS cord-005453-4057qib7 3034 22 were be VBD cord-005453-4057qib7 3034 23 seen see VBN cord-005453-4057qib7 3034 24 in in IN cord-005453-4057qib7 3034 25 changes change NNS cord-005453-4057qib7 3034 26 of of IN cord-005453-4057qib7 3034 27 jumping jump VBG cord-005453-4057qib7 3034 28 height height NN cord-005453-4057qib7 3034 29 from from IN cord-005453-4057qib7 3034 30 pre pre NN cord-005453-4057qib7 3034 31 - - NN cord-005453-4057qib7 3034 32 to to TO cord-005453-4057qib7 3034 33 follow follow VB cord-005453-4057qib7 3034 34 - - HYPH cord-005453-4057qib7 3034 35 up up NN cord-005453-4057qib7 3034 36 - - HYPH cord-005453-4057qib7 3034 37 assessment assessment NN cord-005453-4057qib7 3034 38 ( ( -LRB- cord-005453-4057qib7 3034 39 P=0.033 P=0.033 NNP cord-005453-4057qib7 3034 40 ) ) -RRB- cord-005453-4057qib7 3034 41 : : : cord-005453-4057qib7 3034 42 increase increase VB cord-005453-4057qib7 3034 43 in in IN cord-005453-4057qib7 3034 44 the the DT cord-005453-4057qib7 3034 45 IG ig NN cord-005453-4057qib7 3034 46 and and CC cord-005453-4057qib7 3034 47 decrease decrease NN cord-005453-4057qib7 3034 48 in in IN cord-005453-4057qib7 3034 49 the the DT cord-005453-4057qib7 3034 50 CG CG NNP cord-005453-4057qib7 3034 51 . . . cord-005453-4057qib7 3035 1 The the DT cord-005453-4057qib7 3035 2 IG IG NNP cord-005453-4057qib7 3035 3 showed show VBD cord-005453-4057qib7 3035 4 a a DT cord-005453-4057qib7 3035 5 decrease decrease NN cord-005453-4057qib7 3035 6 in in IN cord-005453-4057qib7 3035 7 time time NN cord-005453-4057qib7 3035 8 from from IN cord-005453-4057qib7 3035 9 baseline baseline NN cord-005453-4057qib7 3035 10 to to IN cord-005453-4057qib7 3035 11 follow follow VB cord-005453-4057qib7 3035 12 - - HYPH cord-005453-4057qib7 3035 13 up up NN cord-005453-4057qib7 3035 14 ( ( -LRB- cord-005453-4057qib7 3035 15 P=0.022 p=0.022 NN cord-005453-4057qib7 3035 16 ) ) -RRB- cord-005453-4057qib7 3035 17 in in IN cord-005453-4057qib7 3035 18 the the DT cord-005453-4057qib7 3035 19 CRT CRT NNP cord-005453-4057qib7 3035 20 and and CC cord-005453-4057qib7 3035 21 an an DT cord-005453-4057qib7 3035 22 increase increase NN cord-005453-4057qib7 3035 23 of of IN cord-005453-4057qib7 3035 24 power power NN cord-005453-4057qib7 3035 25 output output NN cord-005453-4057qib7 3035 26 ( ( -LRB- cord-005453-4057qib7 3035 27 P=0.009 p=0.009 NN cord-005453-4057qib7 3035 28 ) ) -RRB- cord-005453-4057qib7 3035 29 . . . cord-005453-4057qib7 3036 1 QoL QoL NNP cord-005453-4057qib7 3036 2 decreased decrease VBD cord-005453-4057qib7 3036 3 only only RB cord-005453-4057qib7 3036 4 in in IN cord-005453-4057qib7 3036 5 the the DT cord-005453-4057qib7 3036 6 CG CG NNP cord-005453-4057qib7 3036 7 during during IN cord-005453-4057qib7 3036 8 hospitalization hospitalization NN cord-005453-4057qib7 3036 9 ( ( -LRB- cord-005453-4057qib7 3036 10 P=0.015 P=0.015 NNP cord-005453-4057qib7 3036 11 ) ) -RRB- cord-005453-4057qib7 3036 12 while while IN cord-005453-4057qib7 3036 13 during during IN cord-005453-4057qib7 3036 14 follow follow NN cord-005453-4057qib7 3036 15 - - HYPH cord-005453-4057qib7 3036 16 up up NN cord-005453-4057qib7 3036 17 QoL qol NN cord-005453-4057qib7 3036 18 increased increase VBD cord-005453-4057qib7 3036 19 in in IN cord-005453-4057qib7 3036 20 both both DT cord-005453-4057qib7 3036 21 groups group NNS cord-005453-4057qib7 3036 22 ( ( -LRB- cord-005453-4057qib7 3036 23 IG IG NNP cord-005453-4057qib7 3036 24 : : : cord-005453-4057qib7 3036 25 P=0.013 p=0.013 NN cord-005453-4057qib7 3036 26 ; ; : cord-005453-4057qib7 3036 27 CG cg NN cord-005453-4057qib7 3036 28 : : : cord-005453-4057qib7 3036 29 P=0.037 P=0.037 NNP cord-005453-4057qib7 3036 30 ) ) -RRB- cord-005453-4057qib7 3036 31 . . . cord-005453-4057qib7 3037 1 In in IN cord-005453-4057qib7 3037 2 the the DT cord-005453-4057qib7 3037 3 CG CG NNP cord-005453-4057qib7 3037 4 physical physical JJ cord-005453-4057qib7 3037 5 functioning functioning NN cord-005453-4057qib7 3037 6 decreased decrease VBD cord-005453-4057qib7 3037 7 during during IN cord-005453-4057qib7 3037 8 intervention intervention NN cord-005453-4057qib7 3037 9 ( ( -LRB- cord-005453-4057qib7 3037 10 P=0.001 P=0.001 NNP cord-005453-4057qib7 3037 11 ) ) -RRB- cord-005453-4057qib7 3037 12 whereas whereas IN cord-005453-4057qib7 3037 13 an an DT cord-005453-4057qib7 3037 14 increase increase NN cord-005453-4057qib7 3037 15 was be VBD cord-005453-4057qib7 3037 16 seen see VBN cord-005453-4057qib7 3037 17 in in IN cord-005453-4057qib7 3037 18 the the DT cord-005453-4057qib7 3037 19 IG ig NN cord-005453-4057qib7 3037 20 from from IN cord-005453-4057qib7 3037 21 pre pre NN cord-005453-4057qib7 3037 22 - - VB cord-005453-4057qib7 3037 23 to to TO cord-005453-4057qib7 3037 24 follow follow VB cord-005453-4057qib7 3037 25 - - HYPH cord-005453-4057qib7 3037 26 upassessment upassessment NN cord-005453-4057qib7 3037 27 ( ( -LRB- cord-005453-4057qib7 3037 28 P=0.035 p=0.035 NN cord-005453-4057qib7 3037 29 ) ) -RRB- cord-005453-4057qib7 3037 30 . . . cord-005453-4057qib7 3038 1 Body body NN cord-005453-4057qib7 3038 2 image image NN cord-005453-4057qib7 3038 3 was be VBD cord-005453-4057qib7 3038 4 significant significant JJ cord-005453-4057qib7 3038 5 worse bad JJR cord-005453-4057qib7 3038 6 in in IN cord-005453-4057qib7 3038 7 the the DT cord-005453-4057qib7 3038 8 CG CG NNP cord-005453-4057qib7 3038 9 compared compare VBN cord-005453-4057qib7 3038 10 to to IN cord-005453-4057qib7 3038 11 the the DT cord-005453-4057qib7 3038 12 IG IG NNP cord-005453-4057qib7 3038 13 at at IN cord-005453-4057qib7 3038 14 hospital hospital NN cord-005453-4057qib7 3038 15 discharge discharge NN cord-005453-4057qib7 3038 16 ( ( -LRB- cord-005453-4057qib7 3038 17 P=0.007 p=0.007 NN cord-005453-4057qib7 3038 18 ) ) -RRB- cord-005453-4057qib7 3038 19 as as RB cord-005453-4057qib7 3038 20 well well RB cord-005453-4057qib7 3038 21 as as IN cord-005453-4057qib7 3038 22 at at IN cord-005453-4057qib7 3038 23 follow follow NN cord-005453-4057qib7 3038 24 - - HYPH cord-005453-4057qib7 3038 25 up up NN cord-005453-4057qib7 3038 26 measurement measurement NN cord-005453-4057qib7 3038 27 ( ( -LRB- cord-005453-4057qib7 3038 28 P=0.030 p=0.030 NN cord-005453-4057qib7 3038 29 ) ) -RRB- cord-005453-4057qib7 3038 30 where where WRB cord-005453-4057qib7 3038 31 it -PRON- PRP cord-005453-4057qib7 3038 32 got get VBD cord-005453-4057qib7 3038 33 worse bad JJR cord-005453-4057qib7 3038 34 over over IN cord-005453-4057qib7 3038 35 time time NN cord-005453-4057qib7 3038 36 ( ( -LRB- cord-005453-4057qib7 3038 37 P=0.036 p=0.036 NN cord-005453-4057qib7 3038 38 ) ) -RRB- cord-005453-4057qib7 3038 39 . . . cord-005453-4057qib7 3039 1 Conclusions conclusion NNS cord-005453-4057qib7 3039 2 : : : cord-005453-4057qib7 3040 1 WBV wbv NN cord-005453-4057qib7 3040 2 was be VBD cord-005453-4057qib7 3040 3 shown show VBN cord-005453-4057qib7 3040 4 to to TO cord-005453-4057qib7 3040 5 maintain maintain VB cord-005453-4057qib7 3040 6 maximum maximum JJ cord-005453-4057qib7 3040 7 strength strength NN cord-005453-4057qib7 3040 8 , , , cord-005453-4057qib7 3040 9 jumping jump VBG cord-005453-4057qib7 3040 10 performance performance NN cord-005453-4057qib7 3040 11 and and CC cord-005453-4057qib7 3040 12 QoL qol NN cord-005453-4057qib7 3040 13 during during IN cord-005453-4057qib7 3040 14 alloHCT alloHCT NNP cord-005453-4057qib7 3040 15 . . . cord-005453-4057qib7 3041 1 Although although IN cord-005453-4057qib7 3041 2 cardiorespiratory cardiorespiratory JJ cord-005453-4057qib7 3041 3 fitness fitness NN cord-005453-4057qib7 3041 4 could could MD cord-005453-4057qib7 3041 5 not not RB cord-005453-4057qib7 3041 6 be be VB cord-005453-4057qib7 3041 7 maintained maintain VBN cord-005453-4057qib7 3041 8 by by IN cord-005453-4057qib7 3041 9 WBV WBV NNP cord-005453-4057qib7 3041 10 during during IN cord-005453-4057qib7 3041 11 hospitalization hospitalization NN cord-005453-4057qib7 3041 12 , , , cord-005453-4057qib7 3041 13 it -PRON- PRP cord-005453-4057qib7 3041 14 seems seem VBZ cord-005453-4057qib7 3041 15 in in IN cord-005453-4057qib7 3041 16 the the DT cord-005453-4057qib7 3041 17 follow follow NN cord-005453-4057qib7 3041 18 up up RP cord-005453-4057qib7 3041 19 period period NN cord-005453-4057qib7 3041 20 till till IN cord-005453-4057qib7 3041 21 day day NN cord-005453-4057qib7 3041 22 + + SYM cord-005453-4057qib7 3041 23 180 180 CD cord-005453-4057qib7 3041 24 that that DT cord-005453-4057qib7 3041 25 recovery recovery NN cord-005453-4057qib7 3041 26 of of IN cord-005453-4057qib7 3041 27 the the DT cord-005453-4057qib7 3041 28 cardiorespiratory cardiorespiratory JJ cord-005453-4057qib7 3041 29 system system NN cord-005453-4057qib7 3041 30 is be VBZ cord-005453-4057qib7 3041 31 enhanced enhance VBN cord-005453-4057qib7 3041 32 by by IN cord-005453-4057qib7 3041 33 WBV WBV NNP cord-005453-4057qib7 3041 34 carried carry VBD cord-005453-4057qib7 3041 35 out out RP cord-005453-4057qib7 3041 36 during during IN cord-005453-4057qib7 3041 37 alloHST alloHST NNP cord-005453-4057qib7 3041 38 . . . cord-005453-4057qib7 3042 1 Nevertheless nevertheless RB cord-005453-4057qib7 3042 2 reasons reason NNS cord-005453-4057qib7 3042 3 for for IN cord-005453-4057qib7 3042 4 this this DT cord-005453-4057qib7 3042 5 changes change NNS cord-005453-4057qib7 3042 6 in in IN cord-005453-4057qib7 3042 7 recovery recovery NN cord-005453-4057qib7 3042 8 have have VBP cord-005453-4057qib7 3042 9 to to TO cord-005453-4057qib7 3042 10 be be VB cord-005453-4057qib7 3042 11 analyzed analyze VBN cord-005453-4057qib7 3042 12 in in IN cord-005453-4057qib7 3042 13 further further JJ cord-005453-4057qib7 3042 14 studies study NNS cord-005453-4057qib7 3042 15 as as RB cord-005453-4057qib7 3042 16 well well RB cord-005453-4057qib7 3042 17 as as IN cord-005453-4057qib7 3042 18 treatment treatment NN cord-005453-4057qib7 3042 19 effects effect NNS cord-005453-4057qib7 3042 20 of of IN cord-005453-4057qib7 3042 21 WBV wbv NN cord-005453-4057qib7 3042 22 compared compare VBN cord-005453-4057qib7 3042 23 to to IN cord-005453-4057qib7 3042 24 conventional conventional JJ cord-005453-4057qib7 3042 25 resistance resistance NN cord-005453-4057qib7 3042 26 training training NN cord-005453-4057qib7 3042 27 . . . cord-005453-4057qib7 3043 1 Disclosure disclosure NN cord-005453-4057qib7 3043 2 : : : cord-005453-4057qib7 3043 3 Supported support VBN cord-005453-4057qib7 3043 4 by by IN cord-005453-4057qib7 3043 5 a a DT cord-005453-4057qib7 3043 6 grant grant NN cord-005453-4057qib7 3043 7 of of IN cord-005453-4057qib7 3043 8 the the DT cord-005453-4057qib7 3043 9 faculty faculty NN cord-005453-4057qib7 3043 10 of of IN cord-005453-4057qib7 3043 11 medicine medicine NN cord-005453-4057qib7 3043 12 and and CC cord-005453-4057qib7 3043 13 Comprehensive Comprehensive NNP cord-005453-4057qib7 3043 14 Cancer Cancer NNP cord-005453-4057qib7 3043 15 Center Center NNP cord-005453-4057qib7 3043 16 Freiburg Freiburg NNP cord-005453-4057qib7 3043 17 Respiratory respiratory JJ cord-005453-4057qib7 3043 18 virus virus NN cord-005453-4057qib7 3043 19 infection infection NN cord-005453-4057qib7 3043 20 within within IN cord-005453-4057qib7 3043 21 1 1 CD cord-005453-4057qib7 3043 22 year year NN cord-005453-4057qib7 3043 23 after after IN cord-005453-4057qib7 3043 24 of of IN cord-005453-4057qib7 3043 25 Allo Allo NNP cord-005453-4057qib7 3043 26 - - HYPH cord-005453-4057qib7 3043 27 SCT SCT NNP cord-005453-4057qib7 3043 28 is be VBZ cord-005453-4057qib7 3043 29 the the DT cord-005453-4057qib7 3043 30 significant significant JJ cord-005453-4057qib7 3043 31 risk risk NN cord-005453-4057qib7 3043 32 factor factor NN cord-005453-4057qib7 3043 33 of of IN cord-005453-4057qib7 3043 34 obstructive obstructive JJ cord-005453-4057qib7 3043 35 ventilatory ventilatory NN cord-005453-4057qib7 3043 36 disturbance disturbance NN cord-005453-4057qib7 3043 37 Kosei Kosei NNP cord-005453-4057qib7 3043 38 Kageyama Kageyama NNP cord-005453-4057qib7 3043 39 1 1 CD cord-005453-4057qib7 3043 40 , , , cord-005453-4057qib7 3043 41 Michiho Michiho NNP cord-005453-4057qib7 3043 42 Ebihara Ebihara NNP cord-005453-4057qib7 3043 43 1 1 CD cord-005453-4057qib7 3043 44 , , , cord-005453-4057qib7 3043 45 Mitsuhiro Mitsuhiro NNP cord-005453-4057qib7 3043 46 Yuasa Yuasa NNP cord-005453-4057qib7 3043 47 1 1 CD cord-005453-4057qib7 3043 48 , , , cord-005453-4057qib7 3043 49 Daisuke Daisuke NNP cord-005453-4057qib7 3043 50 Kaji Kaji NNP cord-005453-4057qib7 3043 51 1 1 CD cord-005453-4057qib7 3043 52 , , , cord-005453-4057qib7 3043 53 Aya Aya NNP cord-005453-4057qib7 3043 54 Nishida Nishida NNP cord-005453-4057qib7 3043 55 1 1 CD cord-005453-4057qib7 3043 56 , , , cord-005453-4057qib7 3043 57 Shinsuke Shinsuke NNP cord-005453-4057qib7 3043 58 Takagi Takagi NNP cord-005453-4057qib7 3043 59 1 1 CD cord-005453-4057qib7 3043 60 , , , cord-005453-4057qib7 3043 61 Hisashi Hisashi NNP cord-005453-4057qib7 3043 62 Yamamoto Yamamoto NNP cord-005453-4057qib7 3043 63 1 1 CD cord-005453-4057qib7 3043 64 , , , cord-005453-4057qib7 3043 65 Go go VB cord-005453-4057qib7 3043 66 Yamamoto Yamamoto NNP cord-005453-4057qib7 3043 67 1 1 CD cord-005453-4057qib7 3043 68 , , , cord-005453-4057qib7 3043 69 Yuki Yuki NNP cord-005453-4057qib7 3043 70 Asano Asano NNP cord-005453-4057qib7 3043 71 - - HYPH cord-005453-4057qib7 3043 72 Mori Mori NNP cord-005453-4057qib7 3043 73 1 1 CD cord-005453-4057qib7 3043 74 , , , cord-005453-4057qib7 3043 75 Naoyuki Naoyuki NNP cord-005453-4057qib7 3043 76 Uchida Uchida NNP cord-005453-4057qib7 3043 77 1 1 CD cord-005453-4057qib7 3043 78 , , , cord-005453-4057qib7 3044 1 Atsushi Atsushi NNP cord-005453-4057qib7 3044 2 Wake Wake NNP cord-005453-4057qib7 3044 3 1 1 CD cord-005453-4057qib7 3044 4 , , , cord-005453-4057qib7 3044 5 Akiko Akiko NNP cord-005453-4057qib7 3044 6 Yoneyama Yoneyama NNP cord-005453-4057qib7 3044 7 1 1 CD cord-005453-4057qib7 3044 8 , , , cord-005453-4057qib7 3044 9 Shigeyoshi Shigeyoshi NNP cord-005453-4057qib7 3044 10 Makino Makino NNP cord-005453-4057qib7 3044 11 1 1 CD cord-005453-4057qib7 3044 12 , , , cord-005453-4057qib7 3044 13 Shuichi Shuichi NNP cord-005453-4057qib7 3044 14 Taniguchi Taniguchi NNP cord-005453-4057qib7 3044 15 1 1 CD cord-005453-4057qib7 3044 16 1 1 CD cord-005453-4057qib7 3044 17 Toranomon Toranomon NNP cord-005453-4057qib7 3044 18 Hospital Hospital NNP cord-005453-4057qib7 3044 19 , , , cord-005453-4057qib7 3044 20 Hematology Hematology NNP cord-005453-4057qib7 3044 21 , , , cord-005453-4057qib7 3044 22 Tokyo Tokyo NNP cord-005453-4057qib7 3044 23 , , , cord-005453-4057qib7 3044 24 Japan Japan NNP cord-005453-4057qib7 3044 25 , , , cord-005453-4057qib7 3045 1 Background background NN cord-005453-4057qib7 3045 2 : : : cord-005453-4057qib7 3046 1 Obstructive obstructive JJ cord-005453-4057qib7 3046 2 ventilatory ventilatory JJ cord-005453-4057qib7 3046 3 disturbance disturbance NN cord-005453-4057qib7 3046 4 ( ( -LRB- cord-005453-4057qib7 3046 5 OVD OVD NNP cord-005453-4057qib7 3046 6 ) ) -RRB- cord-005453-4057qib7 3046 7 is be VBZ cord-005453-4057qib7 3046 8 one one CD cord-005453-4057qib7 3046 9 of of IN cord-005453-4057qib7 3046 10 the the DT cord-005453-4057qib7 3046 11 major major JJ cord-005453-4057qib7 3046 12 life life NN cord-005453-4057qib7 3046 13 - - HYPH cord-005453-4057qib7 3046 14 threading thread VBG cord-005453-4057qib7 3046 15 complication complication NN cord-005453-4057qib7 3046 16 at at IN cord-005453-4057qib7 3046 17 the the DT cord-005453-4057qib7 3046 18 chronic chronic JJ cord-005453-4057qib7 3046 19 phase phase NN cord-005453-4057qib7 3046 20 of of IN cord-005453-4057qib7 3046 21 allogeneic allogeneic NN cord-005453-4057qib7 3046 22 stem stem NN cord-005453-4057qib7 3046 23 cell cell NN cord-005453-4057qib7 3046 24 transplantation transplantation NN cord-005453-4057qib7 3046 25 ( ( -LRB- cord-005453-4057qib7 3046 26 Allo Allo NNP cord-005453-4057qib7 3046 27 - - HYPH cord-005453-4057qib7 3046 28 SCT SCT NNP cord-005453-4057qib7 3046 29 ) ) -RRB- cord-005453-4057qib7 3046 30 . . . cord-005453-4057qib7 3047 1 Bronchiolitis Bronchiolitis NNP cord-005453-4057qib7 3047 2 obliterans obliterans NNP cord-005453-4057qib7 3047 3 has have VBZ cord-005453-4057qib7 3047 4 been be VBN cord-005453-4057qib7 3047 5 the the DT cord-005453-4057qib7 3047 6 most most RBS cord-005453-4057qib7 3047 7 established established JJ cord-005453-4057qib7 3047 8 etiology etiology NN cord-005453-4057qib7 3047 9 as as IN cord-005453-4057qib7 3047 10 a a DT cord-005453-4057qib7 3047 11 part part NN cord-005453-4057qib7 3047 12 of of IN cord-005453-4057qib7 3047 13 chronic chronic JJ cord-005453-4057qib7 3047 14 graft graft NN cord-005453-4057qib7 3047 15 - - HYPH cord-005453-4057qib7 3047 16 versus versus IN cord-005453-4057qib7 3047 17 - - HYPH cord-005453-4057qib7 3047 18 host host NN cord-005453-4057qib7 3047 19 disease disease NN cord-005453-4057qib7 3047 20 and and CC cord-005453-4057qib7 3047 21 major major JJ cord-005453-4057qib7 3047 22 cause cause NN cord-005453-4057qib7 3047 23 of of IN cord-005453-4057qib7 3047 24 late late JJ cord-005453-4057qib7 3047 25 non non JJ cord-005453-4057qib7 3047 26 - - JJ cord-005453-4057qib7 3047 27 relapse relapse JJ cord-005453-4057qib7 3047 28 mortality mortality NN cord-005453-4057qib7 3047 29 of of IN cord-005453-4057qib7 3047 30 Allo Allo NNP cord-005453-4057qib7 3047 31 - - HYPH cord-005453-4057qib7 3047 32 SCT SCT NNP cord-005453-4057qib7 3047 33 . . . cord-005453-4057qib7 3048 1 But but CC cord-005453-4057qib7 3048 2 other other JJ cord-005453-4057qib7 3048 3 etiologies etiology NNS cord-005453-4057qib7 3048 4 impact impact VBP cord-005453-4057qib7 3048 5 on on IN cord-005453-4057qib7 3048 6 respiratory respiratory JJ cord-005453-4057qib7 3048 7 function function NN cord-005453-4057qib7 3048 8 after after IN cord-005453-4057qib7 3048 9 Allo Allo NNP cord-005453-4057qib7 3048 10 - - HYPH cord-005453-4057qib7 3048 11 SCT sct NN cord-005453-4057qib7 3048 12 and and CC cord-005453-4057qib7 3048 13 risk risk NN cord-005453-4057qib7 3048 14 factor factor NN cord-005453-4057qib7 3048 15 of of IN cord-005453-4057qib7 3048 16 OVD OVD NNP cord-005453-4057qib7 3048 17 have have VBP cord-005453-4057qib7 3048 18 not not RB cord-005453-4057qib7 3048 19 been be VBN cord-005453-4057qib7 3048 20 well well RB cord-005453-4057qib7 3048 21 understood understand VBN cord-005453-4057qib7 3048 22 . . . cord-005453-4057qib7 3049 1 Methods method NNS cord-005453-4057qib7 3049 2 : : : cord-005453-4057qib7 3049 3 To to TO cord-005453-4057qib7 3049 4 address address VB cord-005453-4057qib7 3049 5 these these DT cord-005453-4057qib7 3049 6 issues issue NNS cord-005453-4057qib7 3049 7 , , , cord-005453-4057qib7 3049 8 we -PRON- PRP cord-005453-4057qib7 3049 9 retrospectively retrospectively RB cord-005453-4057qib7 3049 10 reviewed review VBD cord-005453-4057qib7 3049 11 the the DT cord-005453-4057qib7 3049 12 medical medical JJ cord-005453-4057qib7 3049 13 record record NN cord-005453-4057qib7 3049 14 of of IN cord-005453-4057qib7 3049 15 747 747 CD cord-005453-4057qib7 3049 16 consecutive consecutive JJ cord-005453-4057qib7 3049 17 patients patient NNS cord-005453-4057qib7 3049 18 who who WP cord-005453-4057qib7 3049 19 first first RB cord-005453-4057qib7 3049 20 Allo Allo NNP cord-005453-4057qib7 3049 21 - - HYPH cord-005453-4057qib7 3049 22 SCT SCT NNP cord-005453-4057qib7 3049 23 at at IN cord-005453-4057qib7 3049 24 Toranomon Toranomon NNP cord-005453-4057qib7 3049 25 Hospital Hospital NNP cord-005453-4057qib7 3049 26 between between IN cord-005453-4057qib7 3049 27 2009 2009 CD cord-005453-4057qib7 3049 28 and and CC cord-005453-4057qib7 3049 29 2017 2017 CD cord-005453-4057qib7 3049 30 . . . cord-005453-4057qib7 3050 1 To to TO cord-005453-4057qib7 3050 2 detect detect VB cord-005453-4057qib7 3050 3 OVD OVD NNP cord-005453-4057qib7 3050 4 , , , cord-005453-4057qib7 3050 5 forced force VBN cord-005453-4057qib7 3050 6 expiratory expiratory JJ cord-005453-4057qib7 3050 7 volume volume NN cord-005453-4057qib7 3050 8 in in IN cord-005453-4057qib7 3050 9 1 1 CD cord-005453-4057qib7 3050 10 second second NN cord-005453-4057qib7 3050 11 ( ( -LRB- cord-005453-4057qib7 3050 12 FEV1.0 FEV1.0 NNP cord-005453-4057qib7 3050 13 ) ) -RRB- cord-005453-4057qib7 3050 14 showed show VBD cord-005453-4057qib7 3050 15 less less JJR cord-005453-4057qib7 3050 16 than than IN cord-005453-4057qib7 3050 17 80 80 CD cord-005453-4057qib7 3050 18 % % NN cord-005453-4057qib7 3050 19 of of IN cord-005453-4057qib7 3050 20 predicted predict VBN cord-005453-4057qib7 3050 21 in in IN cord-005453-4057qib7 3050 22 spirometry spirometry NN cord-005453-4057qib7 3050 23 test test NN cord-005453-4057qib7 3050 24 was be VBD cord-005453-4057qib7 3050 25 defined define VBN cord-005453-4057qib7 3050 26 as as IN cord-005453-4057qib7 3050 27 positive positive JJ cord-005453-4057qib7 3050 28 . . . cord-005453-4057qib7 3051 1 In in IN cord-005453-4057qib7 3051 2 the the DT cord-005453-4057qib7 3051 3 recipients recipient NNS cord-005453-4057qib7 3051 4 who who WP cord-005453-4057qib7 3051 5 showed show VBD cord-005453-4057qib7 3051 6 FEV1.0 FEV1.0 NNP cord-005453-4057qib7 3051 7 less less JJR cord-005453-4057qib7 3051 8 than than IN cord-005453-4057qib7 3051 9 80 80 CD cord-005453-4057qib7 3051 10 % % NN cord-005453-4057qib7 3051 11 in in IN cord-005453-4057qib7 3051 12 pre pre JJ cord-005453-4057qib7 3051 13 - - JJ cord-005453-4057qib7 3051 14 transplant transplant JJ cord-005453-4057qib7 3051 15 test test NN cord-005453-4057qib7 3051 16 , , , cord-005453-4057qib7 3051 17 more more JJR cord-005453-4057qib7 3051 18 than than IN cord-005453-4057qib7 3051 19 20 20 CD cord-005453-4057qib7 3051 20 % % NN cord-005453-4057qib7 3051 21 reduction reduction NN cord-005453-4057qib7 3051 22 of of IN cord-005453-4057qib7 3051 23 FEV1.0 FEV1.0 NNP cord-005453-4057qib7 3051 24 was be VBD cord-005453-4057qib7 3051 25 regarded regard VBN cord-005453-4057qib7 3051 26 as as IN cord-005453-4057qib7 3051 27 positive positive JJ cord-005453-4057qib7 3051 28 . . . cord-005453-4057qib7 3052 1 Nasopharyngeal nasopharyngeal JJ cord-005453-4057qib7 3052 2 swab swab NN cord-005453-4057qib7 3052 3 of of IN cord-005453-4057qib7 3052 4 those those DT cord-005453-4057qib7 3052 5 who who WP cord-005453-4057qib7 3052 6 had have VBD cord-005453-4057qib7 3052 7 upper upper JJ cord-005453-4057qib7 3052 8 respiratory respiratory JJ cord-005453-4057qib7 3052 9 tract tract NN cord-005453-4057qib7 3052 10 symptoms symptom NNS cord-005453-4057qib7 3052 11 were be VBD cord-005453-4057qib7 3052 12 tested test VBN cord-005453-4057qib7 3052 13 for for IN cord-005453-4057qib7 3052 14 the the DT cord-005453-4057qib7 3052 15 presence presence NN cord-005453-4057qib7 3052 16 of of IN cord-005453-4057qib7 3052 17 respiratory respiratory JJ cord-005453-4057qib7 3052 18 viral viral JJ cord-005453-4057qib7 3052 19 antigens antigen NNS cord-005453-4057qib7 3052 20 ( ( -LRB- cord-005453-4057qib7 3052 21 ADV ADV NNP cord-005453-4057qib7 3052 22 , , , cord-005453-4057qib7 3052 23 PIV PIV NNP cord-005453-4057qib7 3052 24 , , , cord-005453-4057qib7 3052 25 and and CC cord-005453-4057qib7 3052 26 RSV RSV NNP cord-005453-4057qib7 3052 27 ) ) -RRB- cord-005453-4057qib7 3052 28 . . . cord-005453-4057qib7 3053 1 Patients patient NNS cord-005453-4057qib7 3053 2 with with IN cord-005453-4057qib7 3053 3 ECOG ECOG NNP cord-005453-4057qib7 3053 4 performance performance NN cord-005453-4057qib7 3053 5 status status NN cord-005453-4057qib7 3053 6 of of IN cord-005453-4057qib7 3053 7 4 4 CD cord-005453-4057qib7 3053 8 , , , cord-005453-4057qib7 3053 9 had have VBD cord-005453-4057qib7 3053 10 active active JJ cord-005453-4057qib7 3053 11 infection infection NN cord-005453-4057qib7 3053 12 at at IN cord-005453-4057qib7 3053 13 transplant transplant NN cord-005453-4057qib7 3053 14 were be VBD cord-005453-4057qib7 3053 15 excluded exclude VBN cord-005453-4057qib7 3053 16 from from IN cord-005453-4057qib7 3053 17 this this DT cord-005453-4057qib7 3053 18 analysis analysis NN cord-005453-4057qib7 3053 19 . . . cord-005453-4057qib7 3054 1 The the DT cord-005453-4057qib7 3054 2 cases case NNS cord-005453-4057qib7 3054 3 of of IN cord-005453-4057qib7 3054 4 early early JJ cord-005453-4057qib7 3054 5 death death NN cord-005453-4057qib7 3054 6 or or CC cord-005453-4057qib7 3054 7 relapse relapse NN cord-005453-4057qib7 3054 8 before before IN cord-005453-4057qib7 3054 9 30 30 CD cord-005453-4057qib7 3054 10 days day NNS cord-005453-4057qib7 3054 11 post post NN cord-005453-4057qib7 3054 12 - - NN cord-005453-4057qib7 3054 13 transplant transplant NN cord-005453-4057qib7 3054 14 , , , cord-005453-4057qib7 3054 15 and and CC cord-005453-4057qib7 3054 16 the the DT cord-005453-4057qib7 3054 17 cases case NNS cord-005453-4057qib7 3054 18 of of IN cord-005453-4057qib7 3054 19 graft graft NN cord-005453-4057qib7 3054 20 failure failure NN cord-005453-4057qib7 3054 21 were be VBD cord-005453-4057qib7 3054 22 also also RB cord-005453-4057qib7 3054 23 excluded exclude VBN cord-005453-4057qib7 3054 24 . . . cord-005453-4057qib7 3055 1 Results result NNS cord-005453-4057qib7 3055 2 : : : cord-005453-4057qib7 3056 1 The the DT cord-005453-4057qib7 3056 2 median median JJ cord-005453-4057qib7 3056 3 age age NN cord-005453-4057qib7 3056 4 was be VBD cord-005453-4057qib7 3056 5 55 55 CD cord-005453-4057qib7 3056 6 years year NNS cord-005453-4057qib7 3057 1 ( ( -LRB- cord-005453-4057qib7 3057 2 range range NN cord-005453-4057qib7 3057 3 , , , cord-005453-4057qib7 3057 4 16 16 CD cord-005453-4057qib7 3057 5 - - SYM cord-005453-4057qib7 3057 6 74 74 CD cord-005453-4057qib7 3057 7 ) ) -RRB- cord-005453-4057qib7 3057 8 . . . cord-005453-4057qib7 3058 1 Underlying underlie VBG cord-005453-4057qib7 3058 2 diseases disease NNS cord-005453-4057qib7 3058 3 were be VBD cord-005453-4057qib7 3058 4 AML AML NNP cord-005453-4057qib7 3058 5 in in IN cord-005453-4057qib7 3058 6 403 403 CD cord-005453-4057qib7 3058 7 , , , cord-005453-4057qib7 3058 8 MDS MDS NNP cord-005453-4057qib7 3058 9 / / SYM cord-005453-4057qib7 3058 10 MPD MPD NNP cord-005453-4057qib7 3058 11 in in IN cord-005453-4057qib7 3058 12 73 73 CD cord-005453-4057qib7 3058 13 , , , cord-005453-4057qib7 3058 14 CML CML NNP cord-005453-4057qib7 3058 15 in in IN cord-005453-4057qib7 3058 16 26 26 CD cord-005453-4057qib7 3058 17 , , , cord-005453-4057qib7 3058 18 ALL all DT cord-005453-4057qib7 3058 19 in in IN cord-005453-4057qib7 3058 20 82 82 CD cord-005453-4057qib7 3058 21 , , , cord-005453-4057qib7 3058 22 ATL ATL NNP cord-005453-4057qib7 3058 23 in in IN cord-005453-4057qib7 3058 24 19 19 CD cord-005453-4057qib7 3058 25 , , , cord-005453-4057qib7 3058 26 HL HL NNP cord-005453-4057qib7 3058 27 in in IN cord-005453-4057qib7 3058 28 12 12 CD cord-005453-4057qib7 3058 29 , , , cord-005453-4057qib7 3058 30 NHL NHL NNP cord-005453-4057qib7 3058 31 in in IN cord-005453-4057qib7 3058 32 104 104 CD cord-005453-4057qib7 3058 33 , , , cord-005453-4057qib7 3058 34 and and CC cord-005453-4057qib7 3058 35 others other NNS cord-005453-4057qib7 3058 36 in in IN cord-005453-4057qib7 3058 37 28 28 CD cord-005453-4057qib7 3058 38 . . . cord-005453-4057qib7 3059 1 Five five CD cord-005453-4057qib7 3059 2 hundred hundred CD cord-005453-4057qib7 3059 3 twenty twenty CD cord-005453-4057qib7 3059 4 - - HYPH cord-005453-4057qib7 3059 5 nine nine CD cord-005453-4057qib7 3059 6 ( ( -LRB- cord-005453-4057qib7 3059 7 71 71 CD cord-005453-4057qib7 3059 8 % % NN cord-005453-4057qib7 3059 9 ) ) -RRB- cord-005453-4057qib7 3059 10 were be VBD cord-005453-4057qib7 3059 11 not not RB cord-005453-4057qib7 3059 12 in in IN cord-005453-4057qib7 3059 13 remission remission NN cord-005453-4057qib7 3059 14 at at IN cord-005453-4057qib7 3059 15 the the DT cord-005453-4057qib7 3059 16 time time NN cord-005453-4057qib7 3059 17 of of IN cord-005453-4057qib7 3059 18 transplant transplant NN cord-005453-4057qib7 3059 19 . . . cord-005453-4057qib7 3060 1 Five five CD cord-005453-4057qib7 3060 2 hundred hundred CD cord-005453-4057qib7 3060 3 eightythree eightythree NNP cord-005453-4057qib7 3060 4 patients patient NNS cord-005453-4057qib7 3060 5 ( ( -LRB- cord-005453-4057qib7 3060 6 78 78 CD cord-005453-4057qib7 3060 7 % % NN cord-005453-4057qib7 3060 8 ) ) -RRB- cord-005453-4057qib7 3060 9 were be VBD cord-005453-4057qib7 3060 10 conditioned condition VBN cord-005453-4057qib7 3060 11 with with IN cord-005453-4057qib7 3060 12 myeloablative myeloablative JJ cord-005453-4057qib7 3060 13 regimens regimen NNS cord-005453-4057qib7 3060 14 , , , cord-005453-4057qib7 3060 15 whereas whereas IN cord-005453-4057qib7 3060 16 164 164 CD cord-005453-4057qib7 3060 17 patients patient NNS cord-005453-4057qib7 3060 18 received receive VBD cord-005453-4057qib7 3060 19 reduced reduce VBN cord-005453-4057qib7 3060 20 - - HYPH cord-005453-4057qib7 3060 21 intensity intensity NN cord-005453-4057qib7 3060 22 regimens regimen NNS cord-005453-4057qib7 3060 23 . . . cord-005453-4057qib7 3061 1 Donor donor NN cord-005453-4057qib7 3061 2 sources source NNS cord-005453-4057qib7 3061 3 consisted consist VBD cord-005453-4057qib7 3061 4 of of IN cord-005453-4057qib7 3061 5 related related JJ cord-005453-4057qib7 3061 6 peripheral peripheral JJ cord-005453-4057qib7 3061 7 blood blood NN cord-005453-4057qib7 3061 8 /bone /bone . cord-005453-4057qib7 3061 9 marrow marrow NN cord-005453-4057qib7 3061 10 ( ( -LRB- cord-005453-4057qib7 3061 11 BM BM NNP cord-005453-4057qib7 3061 12 ) ) -RRB- cord-005453-4057qib7 3061 13 ( ( -LRB- cord-005453-4057qib7 3061 14 n=85 n=85 NNP cord-005453-4057qib7 3061 15 ) ) -RRB- cord-005453-4057qib7 3061 16 , , , cord-005453-4057qib7 3061 17 unrelated unrelated JJ cord-005453-4057qib7 3061 18 BM BM NNP cord-005453-4057qib7 3061 19 ( ( -LRB- cord-005453-4057qib7 3061 20 153 153 CD cord-005453-4057qib7 3061 21 ) ) -RRB- cord-005453-4057qib7 3061 22 Forty forty CD cord-005453-4057qib7 3061 23 - - HYPH cord-005453-4057qib7 3061 24 six six CD cord-005453-4057qib7 3061 25 developed develop VBD cord-005453-4057qib7 3061 26 OVD OVD NNP cord-005453-4057qib7 3061 27 on on IN cord-005453-4057qib7 3061 28 median median NN cord-005453-4057qib7 3061 29 of of IN cord-005453-4057qib7 3061 30 198 198 CD cord-005453-4057qib7 3062 1 ( ( -LRB- cord-005453-4057qib7 3062 2 60 60 CD cord-005453-4057qib7 3062 3 - - SYM cord-005453-4057qib7 3062 4 804 804 CD cord-005453-4057qib7 3062 5 ) ) -RRB- cord-005453-4057qib7 3062 6 days day NNS cord-005453-4057qib7 3062 7 post post NN cord-005453-4057qib7 3062 8 - - NN cord-005453-4057qib7 3062 9 transplant transplant NN cord-005453-4057qib7 3062 10 . . . cord-005453-4057qib7 3063 1 Cumulative cumulative JJ cord-005453-4057qib7 3063 2 incidence incidence NN cord-005453-4057qib7 3063 3 of of IN cord-005453-4057qib7 3063 4 OVD OVD NNP cord-005453-4057qib7 3063 5 was be VBD cord-005453-4057qib7 3063 6 6.4 6.4 CD cord-005453-4057qib7 3063 7 % % NN cord-005453-4057qib7 3063 8 in in IN cord-005453-4057qib7 3063 9 total total JJ cord-005453-4057qib7 3063 10 population population NN cord-005453-4057qib7 3063 11 . . . cord-005453-4057qib7 3064 1 In in IN cord-005453-4057qib7 3064 2 490 490 CD cord-005453-4057qib7 3064 3 recipients recipient NNS cord-005453-4057qib7 3064 4 those those DT cord-005453-4057qib7 3064 5 who who WP cord-005453-4057qib7 3064 6 could could MD cord-005453-4057qib7 3064 7 spirometry spirometry VB cord-005453-4057qib7 3064 8 , , , cord-005453-4057qib7 3064 9 overall overall JJ cord-005453-4057qib7 3064 10 survival survival NN cord-005453-4057qib7 3064 11 at at IN cord-005453-4057qib7 3064 12 5 5 CD cord-005453-4057qib7 3064 13 years year NNS cord-005453-4057qib7 3064 14 was be VBD cord-005453-4057qib7 3064 15 73.2 73.2 CD cord-005453-4057qib7 3064 16 % % NN cord-005453-4057qib7 3064 17 in in IN cord-005453-4057qib7 3064 18 patients patient NNS cord-005453-4057qib7 3064 19 who who WP cord-005453-4057qib7 3064 20 developed develop VBD cord-005453-4057qib7 3064 21 OVD OVD NNP cord-005453-4057qib7 3064 22 and and CC cord-005453-4057qib7 3064 23 was be VBD cord-005453-4057qib7 3064 24 comparable comparable JJ cord-005453-4057qib7 3064 25 with with IN cord-005453-4057qib7 3064 26 those those DT cord-005453-4057qib7 3064 27 who who WP cord-005453-4057qib7 3064 28 did do VBD cord-005453-4057qib7 3064 29 not not RB cord-005453-4057qib7 3064 30 develop develop VB cord-005453-4057qib7 3064 31 it -PRON- PRP cord-005453-4057qib7 3064 32 ( ( -LRB- cord-005453-4057qib7 3064 33 64.3 64.3 CD cord-005453-4057qib7 3064 34 % % NN cord-005453-4057qib7 3064 35 , , , cord-005453-4057qib7 3064 36 p=0.486 p=0.486 NN cord-005453-4057qib7 3064 37 ) ) -RRB- cord-005453-4057qib7 3064 38 . . . cord-005453-4057qib7 3065 1 In in IN cord-005453-4057qib7 3065 2 univariate univariate JJ cord-005453-4057qib7 3065 3 analysis analysis NN cord-005453-4057qib7 3065 4 , , , cord-005453-4057qib7 3065 5 disease disease NN cord-005453-4057qib7 3065 6 status status NN cord-005453-4057qib7 3065 7 ( ( -LRB- cord-005453-4057qib7 3065 8 CR CR NNP cord-005453-4057qib7 3065 9 / / SYM cord-005453-4057qib7 3065 10 AA AA NNP cord-005453-4057qib7 3065 11 or or CC cord-005453-4057qib7 3065 12 nonCR nonCR NNP cord-005453-4057qib7 3065 13 ) ) -RRB- cord-005453-4057qib7 3065 14 , , , cord-005453-4057qib7 3065 15 recipient recipient NN cord-005453-4057qib7 3065 16 age age NN cord-005453-4057qib7 3065 17 ( ( -LRB- cord-005453-4057qib7 3065 18 age age NN cord-005453-4057qib7 3065 19 < < XX cord-005453-4057qib7 3065 20 55 55 CD cord-005453-4057qib7 3065 21 or or CC cord-005453-4057qib7 3065 22 ≥55 ≥55 NNP cord-005453-4057qib7 3065 23 ) ) -RRB- cord-005453-4057qib7 3065 24 , , , cord-005453-4057qib7 3065 25 prior prior JJ cord-005453-4057qib7 3065 26 autologous autologous JJ cord-005453-4057qib7 3065 27 stem stem NN cord-005453-4057qib7 3065 28 cell cell NN cord-005453-4057qib7 3065 29 transplantation transplantation NN cord-005453-4057qib7 3065 30 ( ( -LRB- cord-005453-4057qib7 3065 31 yes yes UH cord-005453-4057qib7 3065 32 or or CC cord-005453-4057qib7 3065 33 no no UH cord-005453-4057qib7 3065 34 ) ) -RRB- cord-005453-4057qib7 3065 35 , , , cord-005453-4057qib7 3065 36 intensity intensity NN cord-005453-4057qib7 3065 37 of of IN cord-005453-4057qib7 3065 38 conditioning conditioning NN cord-005453-4057qib7 3065 39 regimen regimen NN cord-005453-4057qib7 3065 40 ( ( -LRB- cord-005453-4057qib7 3065 41 MAC MAC NNP cord-005453-4057qib7 3065 42 or or CC cord-005453-4057qib7 3065 43 RIC RIC NNP cord-005453-4057qib7 3065 44 ) ) -RRB- cord-005453-4057qib7 3065 45 , , , cord-005453-4057qib7 3065 46 TBI TBI NNP cord-005453-4057qib7 3065 47 dose dose NN cord-005453-4057qib7 3065 48 ( ( -LRB- cord-005453-4057qib7 3065 49 < < NNP cord-005453-4057qib7 3065 50 8 8 CD cord-005453-4057qib7 3065 51 Gy Gy NNP cord-005453-4057qib7 3065 52 or or CC cord-005453-4057qib7 3065 53 ≥8 ≥8 NNP cord-005453-4057qib7 3065 54 Gy Gy NNP cord-005453-4057qib7 3065 55 ) ) -RRB- cord-005453-4057qib7 3065 56 , , , cord-005453-4057qib7 3065 57 busulfan busulfan NN cord-005453-4057qib7 3065 58 dose dose NN cord-005453-4057qib7 3065 59 ( ( -LRB- cord-005453-4057qib7 3065 60 < < XX cord-005453-4057qib7 3065 61 9.6mg 9.6mg CD cord-005453-4057qib7 3065 62 / / SYM cord-005453-4057qib7 3065 63 kg kg NN cord-005453-4057qib7 3065 64 or or CC cord-005453-4057qib7 3065 65 ≥9.6mg ≥9.6mg NNS cord-005453-4057qib7 3065 66 / / SYM cord-005453-4057qib7 3065 67 kg kg NNP cord-005453-4057qib7 3065 68 ) ) -RRB- cord-005453-4057qib7 3065 69 , , , cord-005453-4057qib7 3065 70 donor donor NN cord-005453-4057qib7 3065 71 source source NN cord-005453-4057qib7 3065 72 ( ( -LRB- cord-005453-4057qib7 3065 73 cord cord NN cord-005453-4057qib7 3065 74 blood blood NN cord-005453-4057qib7 3065 75 or or CC cord-005453-4057qib7 3065 76 non non JJ cord-005453-4057qib7 3065 77 - - JJ cord-005453-4057qib7 3065 78 cord cord JJ cord-005453-4057qib7 3065 79 ) ) -RRB- cord-005453-4057qib7 3065 80 had have VBD cord-005453-4057qib7 3065 81 no no DT cord-005453-4057qib7 3065 82 impact impact NN cord-005453-4057qib7 3065 83 on on IN cord-005453-4057qib7 3065 84 the the DT cord-005453-4057qib7 3065 85 incidence incidence NN cord-005453-4057qib7 3065 86 of of IN cord-005453-4057qib7 3065 87 OVD OVD NNP cord-005453-4057qib7 3065 88 . . . cord-005453-4057qib7 3066 1 Patients patient NNS cord-005453-4057qib7 3066 2 who who WP cord-005453-4057qib7 3066 3 developed develop VBD cord-005453-4057qib7 3066 4 respiratory respiratory JJ cord-005453-4057qib7 3066 5 virus virus NN cord-005453-4057qib7 3066 6 infection infection NN cord-005453-4057qib7 3066 7 showed show VBD cord-005453-4057qib7 3066 8 significantly significantly RB cord-005453-4057qib7 3066 9 higher high JJR cord-005453-4057qib7 3066 10 incidence incidence NN cord-005453-4057qib7 3066 11 of of IN cord-005453-4057qib7 3066 12 OVD OVD NNP cord-005453-4057qib7 3066 13 compared compare VBN cord-005453-4057qib7 3066 14 to to IN cord-005453-4057qib7 3066 15 those those DT cord-005453-4057qib7 3066 16 who who WP cord-005453-4057qib7 3066 17 did do VBD cord-005453-4057qib7 3066 18 not not RB cord-005453-4057qib7 3066 19 developed develop VBN cord-005453-4057qib7 3066 20 it -PRON- PRP cord-005453-4057qib7 3066 21 ( ( -LRB- cord-005453-4057qib7 3066 22 12.4 12.4 CD cord-005453-4057qib7 3066 23 % % NN cord-005453-4057qib7 3066 24 vs vs IN cord-005453-4057qib7 3066 25 5.3 5.3 CD cord-005453-4057qib7 3066 26 % % NN cord-005453-4057qib7 3066 27 , , , cord-005453-4057qib7 3066 28 p p NN cord-005453-4057qib7 3066 29 < < XX cord-005453-4057qib7 3066 30 0.01 0.01 CD cord-005453-4057qib7 3066 31 ) ) -RRB- cord-005453-4057qib7 3066 32 . . . cord-005453-4057qib7 3067 1 In in IN cord-005453-4057qib7 3067 2 multivariate multivariate JJ cord-005453-4057qib7 3067 3 analysis analysis NN cord-005453-4057qib7 3067 4 , , , cord-005453-4057qib7 3067 5 respiratory respiratory JJ cord-005453-4057qib7 3067 6 virus virus NN cord-005453-4057qib7 3067 7 infection infection NN cord-005453-4057qib7 3067 8 was be VBD cord-005453-4057qib7 3067 9 the the DT cord-005453-4057qib7 3067 10 only only JJ cord-005453-4057qib7 3067 11 significant significant JJ cord-005453-4057qib7 3067 12 risk risk NN cord-005453-4057qib7 3067 13 factor factor NN cord-005453-4057qib7 3067 14 for for IN cord-005453-4057qib7 3067 15 the the DT cord-005453-4057qib7 3067 16 development development NN cord-005453-4057qib7 3067 17 of of IN cord-005453-4057qib7 3067 18 OVD OVD NNP cord-005453-4057qib7 3067 19 ( ( -LRB- cord-005453-4057qib7 3067 20 HR=2.43 hr=2.43 XX cord-005453-4057qib7 3068 1 , , , cord-005453-4057qib7 3068 2 95 95 CD cord-005453-4057qib7 3068 3 % % NN cord-005453-4057qib7 3068 4 CI CI NNP cord-005453-4057qib7 3068 5 1.30 1.30 CD cord-005453-4057qib7 3068 6 - - HYPH cord-005453-4057qib7 3068 7 4.57 4.57 CD cord-005453-4057qib7 3068 8 , , , cord-005453-4057qib7 3068 9 p p NN cord-005453-4057qib7 3068 10 < < XX cord-005453-4057qib7 3068 11 0.01 0.01 CD cord-005453-4057qib7 3068 12 ) ) -RRB- cord-005453-4057qib7 3068 13 . . . cord-005453-4057qib7 3069 1 Conclusions conclusion NNS cord-005453-4057qib7 3069 2 : : : cord-005453-4057qib7 3070 1 Respiratory respiratory JJ cord-005453-4057qib7 3070 2 virus virus NN cord-005453-4057qib7 3070 3 infection infection NN cord-005453-4057qib7 3070 4 within within IN cord-005453-4057qib7 3070 5 1 1 CD cord-005453-4057qib7 3070 6 year year NN cord-005453-4057qib7 3070 7 after after IN cord-005453-4057qib7 3070 8 Allo Allo NNP cord-005453-4057qib7 3070 9 - - HYPH cord-005453-4057qib7 3070 10 SCT SCT NNP cord-005453-4057qib7 3070 11 is be VBZ cord-005453-4057qib7 3070 12 the the DT cord-005453-4057qib7 3070 13 significant significant JJ cord-005453-4057qib7 3070 14 risk risk NN cord-005453-4057qib7 3070 15 factor factor NN cord-005453-4057qib7 3070 16 of of IN cord-005453-4057qib7 3070 17 OVD OVD NNP cord-005453-4057qib7 3070 18 . . . cord-005453-4057qib7 3071 1 Disclosure disclosure NN cord-005453-4057qib7 3071 2 : : : cord-005453-4057qib7 3071 3 Nothing nothing NN cord-005453-4057qib7 3071 4 to to TO cord-005453-4057qib7 3071 5 declare declare VB cord-005453-4057qib7 3071 6 . . . cord-005453-4057qib7 3072 1 Background background NN cord-005453-4057qib7 3072 2 : : : cord-005453-4057qib7 3073 1 Metabolic Metabolic NNP cord-005453-4057qib7 3073 2 Syndrome Syndrome NNP cord-005453-4057qib7 3073 3 ( ( -LRB- cord-005453-4057qib7 3073 4 MetS MetS NNP cord-005453-4057qib7 3073 5 ) ) -RRB- cord-005453-4057qib7 3073 6 is be VBZ cord-005453-4057qib7 3073 7 related relate VBN cord-005453-4057qib7 3073 8 to to IN cord-005453-4057qib7 3073 9 increased increase VBN cord-005453-4057qib7 3073 10 risk risk NN cord-005453-4057qib7 3073 11 of of IN cord-005453-4057qib7 3073 12 cardiovascular cardiovascular JJ cord-005453-4057qib7 3073 13 disease disease NN cord-005453-4057qib7 3073 14 and and CC cord-005453-4057qib7 3073 15 type-2 type-2 NN cord-005453-4057qib7 3073 16 diabetes diabete NNS cord-005453-4057qib7 3073 17 ( ( -LRB- cord-005453-4057qib7 3073 18 DM-2 DM-2 NNP cord-005453-4057qib7 3073 19 ) ) -RRB- cord-005453-4057qib7 3073 20 and and CC cord-005453-4057qib7 3073 21 usually usually RB cord-005453-4057qib7 3073 22 seen see VBN cord-005453-4057qib7 3073 23 in in IN cord-005453-4057qib7 3073 24 overweight overweight JJ cord-005453-4057qib7 3073 25 individuals individual NNS cord-005453-4057qib7 3073 26 in in IN cord-005453-4057qib7 3073 27 the the DT cord-005453-4057qib7 3073 28 general general JJ cord-005453-4057qib7 3073 29 population population NN cord-005453-4057qib7 3073 30 . . . cord-005453-4057qib7 3074 1 We -PRON- PRP cord-005453-4057qib7 3074 2 investigated investigate VBD cord-005453-4057qib7 3074 3 MetS MetS NNP cord-005453-4057qib7 3074 4 and and CC cord-005453-4057qib7 3074 5 clinical clinical JJ cord-005453-4057qib7 3074 6 risk risk NN cord-005453-4057qib7 3074 7 factors factor NNS cord-005453-4057qib7 3074 8 two two CD cord-005453-4057qib7 3074 9 decades decade NNS cord-005453-4057qib7 3074 10 after after IN cord-005453-4057qib7 3074 11 HSCT HSCT NNP cord-005453-4057qib7 3074 12 . . . cord-005453-4057qib7 3075 1 Methods method NNS cord-005453-4057qib7 3075 2 : : : cord-005453-4057qib7 3076 1 All all DT cord-005453-4057qib7 3076 2 male male JJ cord-005453-4057qib7 3076 3 survivors survivor NNS cord-005453-4057qib7 3076 4 treated treat VBN cord-005453-4057qib7 3076 5 with with IN cord-005453-4057qib7 3076 6 myeloablative myeloablative NNP cord-005453-4057qib7 3076 7 allo allo NNP cord-005453-4057qib7 3076 8 - - HYPH cord-005453-4057qib7 3076 9 HSCT HSCT NNP cord-005453-4057qib7 3076 10 during during IN cord-005453-4057qib7 3076 11 childhood childhood NN cord-005453-4057qib7 3076 12 ( ( -LRB- cord-005453-4057qib7 3076 13 < < NNP cord-005453-4057qib7 3076 14 17 17 CD cord-005453-4057qib7 3076 15 years year NNS cord-005453-4057qib7 3076 16 ) ) -RRB- cord-005453-4057qib7 3076 17 between between IN cord-005453-4057qib7 3076 18 1980 1980 CD cord-005453-4057qib7 3076 19 - - SYM cord-005453-4057qib7 3076 20 2010 2010 CD cord-005453-4057qib7 3076 21 in in IN cord-005453-4057qib7 3076 22 Denmark Denmark NNP cord-005453-4057qib7 3076 23 were be VBD cord-005453-4057qib7 3076 24 invited invite VBN cord-005453-4057qib7 3076 25 to to IN cord-005453-4057qib7 3076 26 a a DT cord-005453-4057qib7 3076 27 follow follow VB cord-005453-4057qib7 3076 28 - - HYPH cord-005453-4057qib7 3076 29 up up NN cord-005453-4057qib7 3076 30 study study NN cord-005453-4057qib7 3076 31 . . . cord-005453-4057qib7 3077 1 MetS MetS NNP cord-005453-4057qib7 3077 2 was be VBD cord-005453-4057qib7 3077 3 defined define VBN cord-005453-4057qib7 3077 4 as as IN cord-005453-4057qib7 3077 5 the the DT cord-005453-4057qib7 3077 6 presence presence NN cord-005453-4057qib7 3077 7 of of IN cord-005453-4057qib7 3077 8 at at RB cord-005453-4057qib7 3077 9 least least RBS cord-005453-4057qib7 3077 10 three three CD cord-005453-4057qib7 3077 11 NCEP NCEP NNP cord-005453-4057qib7 3077 12 ATP ATP NNP cord-005453-4057qib7 3077 13 III III NNP cord-005453-4057qib7 3077 14 criteria criterion NNS cord-005453-4057qib7 3077 15 : : : cord-005453-4057qib7 3077 16 fasting fast VBG cord-005453-4057qib7 3077 17 plasma plasma NN cord-005453-4057qib7 3077 18 triglyceride triglyceride NN cord-005453-4057qib7 3077 19 ( ( -LRB- cord-005453-4057qib7 3077 20 TG TG NNP cord-005453-4057qib7 3077 21 ) ) -RRB- cord-005453-4057qib7 3077 22 ≥1.7 ≥1.7 NNP cord-005453-4057qib7 3077 23 mmol mmol NNP cord-005453-4057qib7 3077 24 / / SYM cord-005453-4057qib7 3077 25 L l NN cord-005453-4057qib7 3077 26 , , , cord-005453-4057qib7 3077 27 high high JJ cord-005453-4057qib7 3077 28 density density NN cord-005453-4057qib7 3077 29 lipoprotein lipoprotein NN cord-005453-4057qib7 3077 30 ( ( -LRB- cord-005453-4057qib7 3077 31 HDL HDL NNP cord-005453-4057qib7 3077 32 ) ) -RRB- cord-005453-4057qib7 3078 1 < < XX cord-005453-4057qib7 3078 2 1.03 1.03 CD cord-005453-4057qib7 3078 3 mmol mmol NNP cord-005453-4057qib7 3078 4 / / SYM cord-005453-4057qib7 3078 5 L L NNP cord-005453-4057qib7 3078 6 or or CC cord-005453-4057qib7 3078 7 medical medical JJ cord-005453-4057qib7 3078 8 treatment treatment NN cord-005453-4057qib7 3078 9 of of IN cord-005453-4057qib7 3078 10 hyperlipidemia hyperlipidemia NN cord-005453-4057qib7 3078 11 ; ; : cord-005453-4057qib7 3078 12 fasting fast VBG cord-005453-4057qib7 3078 13 plasma plasma NN cord-005453-4057qib7 3078 14 glucose glucose NN cord-005453-4057qib7 3078 15 ( ( -LRB- cord-005453-4057qib7 3078 16 FPG FPG NNP cord-005453-4057qib7 3078 17 ) ) -RRB- cord-005453-4057qib7 3078 18 ≥5.6 ≥5.6 NNP cord-005453-4057qib7 3078 19 mmol mmol NNP cord-005453-4057qib7 3078 20 / / SYM cord-005453-4057qib7 3078 21 L l NN cord-005453-4057qib7 3078 22 ; ; : cord-005453-4057qib7 3078 23 abdominal abdominal JJ cord-005453-4057qib7 3078 24 circumference circumference NN cord-005453-4057qib7 3078 25 ( ( -LRB- cord-005453-4057qib7 3078 26 AC ac NN cord-005453-4057qib7 3078 27 ) ) -RRB- cord-005453-4057qib7 3078 28 > > NFP cord-005453-4057qib7 3078 29 102 102 CD cord-005453-4057qib7 3078 30 cm cm NN cord-005453-4057qib7 3079 1 ; ; : cord-005453-4057qib7 3079 2 BP BP NNP cord-005453-4057qib7 3079 3 ≥130 ≥130 `` cord-005453-4057qib7 3079 4 mmHg mmHg NNP cord-005453-4057qib7 3079 5 ( ( -LRB- cord-005453-4057qib7 3079 6 systolic systolic JJ cord-005453-4057qib7 3079 7 ) ) -RRB- cord-005453-4057qib7 3079 8 / / SYM cord-005453-4057qib7 3079 9 ≥85 ≥85 NNP cord-005453-4057qib7 3079 10 mmHg mmHg NNP cord-005453-4057qib7 3079 11 ( ( -LRB- cord-005453-4057qib7 3079 12 diastolic diastolic JJ cord-005453-4057qib7 3079 13 ) ) -RRB- cord-005453-4057qib7 3079 14 or or CC cord-005453-4057qib7 3079 15 medical medical JJ cord-005453-4057qib7 3079 16 treatment treatment NN cord-005453-4057qib7 3079 17 for for IN cord-005453-4057qib7 3079 18 hypertension hypertension NN cord-005453-4057qib7 3079 19 . . . cord-005453-4057qib7 3080 1 Patients patient NNS cord-005453-4057qib7 3080 2 with with IN cord-005453-4057qib7 3081 1 overt overt JJ cord-005453-4057qib7 3081 2 DM-2 DM-2 NNP cord-005453-4057qib7 3081 3 were be VBD cord-005453-4057qib7 3081 4 included include VBN cord-005453-4057qib7 3081 5 into into IN cord-005453-4057qib7 3081 6 the the DT cord-005453-4057qib7 3081 7 MetS MetS NNP cord-005453-4057qib7 3081 8 group group NN cord-005453-4057qib7 3081 9 . . . cord-005453-4057qib7 3082 1 Furthermore furthermore RB cord-005453-4057qib7 3082 2 , , , cord-005453-4057qib7 3082 3 patients patient NNS cord-005453-4057qib7 3082 4 were be VBD cord-005453-4057qib7 3082 5 examined examine VBN cord-005453-4057qib7 3082 6 for for IN cord-005453-4057qib7 3082 7 chronic chronic JJ cord-005453-4057qib7 3082 8 graft graft NN cord-005453-4057qib7 3082 9 - - HYPH cord-005453-4057qib7 3082 10 versus versus IN cord-005453-4057qib7 3082 11 - - HYPH cord-005453-4057qib7 3082 12 host host NN cord-005453-4057qib7 3082 13 disease disease NN cord-005453-4057qib7 3082 14 ( ( -LRB- cord-005453-4057qib7 3082 15 cGvHD cGvHD NNP cord-005453-4057qib7 3082 16 ) ) -RRB- cord-005453-4057qib7 3082 17 by by IN cord-005453-4057qib7 3082 18 the the DT cord-005453-4057qib7 3082 19 NIH NIH NNP cord-005453-4057qib7 3082 20 - - HYPH cord-005453-4057qib7 3082 21 criteria criterion NNS cord-005453-4057qib7 3082 22 at at IN cord-005453-4057qib7 3082 23 the the DT cord-005453-4057qib7 3082 24 time time NN cord-005453-4057qib7 3082 25 of of IN cord-005453-4057qib7 3082 26 follow follow NN cord-005453-4057qib7 3082 27 - - HYPH cord-005453-4057qib7 3082 28 up up NN cord-005453-4057qib7 3082 29 and and CC cord-005453-4057qib7 3082 30 high high JJ cord-005453-4057qib7 3082 31 sensitivity sensitivity NN cord-005453-4057qib7 3082 32 C c NN cord-005453-4057qib7 3082 33 - - HYPH cord-005453-4057qib7 3082 34 reactive reactive JJ cord-005453-4057qib7 3082 35 protein protein NN cord-005453-4057qib7 3082 36 ( ( -LRB- cord-005453-4057qib7 3082 37 hsCRP hscrp NN cord-005453-4057qib7 3082 38 ) ) -RRB- cord-005453-4057qib7 3082 39 was be VBD cord-005453-4057qib7 3082 40 measured measure VBN cord-005453-4057qib7 3082 41 . . . cord-005453-4057qib7 3083 1 The the DT cord-005453-4057qib7 3083 2 prevalence prevalence NN cord-005453-4057qib7 3083 3 of of IN cord-005453-4057qib7 3083 4 MetS MetS NNP cord-005453-4057qib7 3083 5 was be VBD cord-005453-4057qib7 3083 6 compared compare VBN cord-005453-4057qib7 3083 7 to to IN cord-005453-4057qib7 3083 8 a a DT cord-005453-4057qib7 3083 9 Nordic nordic JJ cord-005453-4057qib7 3083 10 reference reference NN cord-005453-4057qib7 3083 11 group group NN cord-005453-4057qib7 3083 12 ( ( -LRB- cord-005453-4057qib7 3083 13 Hildrum Hildrum NNP cord-005453-4057qib7 3083 14 et et NNP cord-005453-4057qib7 3083 15 al al NNP cord-005453-4057qib7 3083 16 . . NNP cord-005453-4057qib7 3083 17 2009 2009 CD cord-005453-4057qib7 3083 18 ) ) -RRB- cord-005453-4057qib7 3083 19 . . . cord-005453-4057qib7 3084 1 Results result NNS cord-005453-4057qib7 3084 2 : : : cord-005453-4057qib7 3085 1 We -PRON- PRP cord-005453-4057qib7 3085 2 included include VBD cord-005453-4057qib7 3085 3 49 49 CD cord-005453-4057qib7 3085 4 out out IN cord-005453-4057qib7 3085 5 of of IN cord-005453-4057qib7 3085 6 97 97 CD cord-005453-4057qib7 3085 7 eligible eligible JJ cord-005453-4057qib7 3085 8 males male NNS cord-005453-4057qib7 3085 9 ( ( -LRB- cord-005453-4057qib7 3085 10 participation participation NN cord-005453-4057qib7 3085 11 rate rate NN cord-005453-4057qib7 3085 12 51 51 CD cord-005453-4057qib7 3085 13 % % NN cord-005453-4057qib7 3085 14 ) ) -RRB- cord-005453-4057qib7 3086 1 aged aged JJ cord-005453-4057qib7 3086 2 18 18 CD cord-005453-4057qib7 3086 3 - - SYM cord-005453-4057qib7 3086 4 44 44 CD cord-005453-4057qib7 3086 5 years year NNS cord-005453-4057qib7 3086 6 , , , cord-005453-4057qib7 3086 7 median median NN cord-005453-4057qib7 3086 8 29 29 CD cord-005453-4057qib7 3086 9 years year NNS cord-005453-4057qib7 3086 10 . . . cord-005453-4057qib7 3087 1 Median median JJ cord-005453-4057qib7 3087 2 ( ( -LRB- cord-005453-4057qib7 3087 3 range range NN cord-005453-4057qib7 3087 4 ) ) -RRB- cord-005453-4057qib7 3087 5 follow follow NN cord-005453-4057qib7 3087 6 - - HYPH cord-005453-4057qib7 3087 7 up up NN cord-005453-4057qib7 3087 8 was be VBD cord-005453-4057qib7 3087 9 21 21 CD cord-005453-4057qib7 3087 10 ( ( -LRB- cord-005453-4057qib7 3087 11 8 8 CD cord-005453-4057qib7 3087 12 - - SYM cord-005453-4057qib7 3087 13 32 32 CD cord-005453-4057qib7 3087 14 ) ) -RRB- cord-005453-4057qib7 3087 15 years year NNS cord-005453-4057qib7 3087 16 . . . cord-005453-4057qib7 3088 1 Of of IN cord-005453-4057qib7 3088 2 these these DT cord-005453-4057qib7 3088 3 49 49 CD cord-005453-4057qib7 3088 4 males male NNS cord-005453-4057qib7 3088 5 , , , cord-005453-4057qib7 3088 6 74 74 CD cord-005453-4057qib7 3088 7 % % NN cord-005453-4057qib7 3088 8 had have VBD cord-005453-4057qib7 3088 9 a a DT cord-005453-4057qib7 3088 10 malignant malignant JJ cord-005453-4057qib7 3088 11 diagnosis diagnosis NN cord-005453-4057qib7 3088 12 and and CC cord-005453-4057qib7 3088 13 65 65 CD cord-005453-4057qib7 3088 14 % % NN cord-005453-4057qib7 3088 15 were be VBD cord-005453-4057qib7 3088 16 treated treat VBN cord-005453-4057qib7 3088 17 with with IN cord-005453-4057qib7 3088 18 TBI TBI NNP cord-005453-4057qib7 3088 19 - - HYPH cord-005453-4057qib7 3088 20 based base VBN cord-005453-4057qib7 3088 21 conditioning conditioning NN cord-005453-4057qib7 3088 22 . . . cord-005453-4057qib7 3089 1 Donors donor NNS cord-005453-4057qib7 3089 2 were be VBD cord-005453-4057qib7 3089 3 matched match VBN cord-005453-4057qib7 3089 4 siblings sibling NNS cord-005453-4057qib7 3089 5 ( ( -LRB- cord-005453-4057qib7 3089 6 n=21 n=21 NNP cord-005453-4057qib7 3089 7 ) ) -RRB- cord-005453-4057qib7 3089 8 , , , cord-005453-4057qib7 3089 9 matched match VBN cord-005453-4057qib7 3089 10 relatives relative NNS cord-005453-4057qib7 3089 11 ( ( -LRB- cord-005453-4057qib7 3089 12 n=3 n=3 NN cord-005453-4057qib7 3089 13 ) ) -RRB- cord-005453-4057qib7 3089 14 or or CC cord-005453-4057qib7 3089 15 matched match VBD cord-005453-4057qib7 3089 16 unrelated unrelated JJ cord-005453-4057qib7 3089 17 donors donor NNS cord-005453-4057qib7 3089 18 ( ( -LRB- cord-005453-4057qib7 3089 19 n=25 n=25 NNP cord-005453-4057qib7 3089 20 ) ) -RRB- cord-005453-4057qib7 3089 21 . . . cord-005453-4057qib7 3090 1 MetS MetS NNP cord-005453-4057qib7 3090 2 was be VBD cord-005453-4057qib7 3090 3 more more RBR cord-005453-4057qib7 3090 4 prevalent prevalent JJ cord-005453-4057qib7 3090 5 ( ( -LRB- cord-005453-4057qib7 3090 6 33 33 CD cord-005453-4057qib7 3090 7 % % NN cord-005453-4057qib7 3090 8 ) ) -RRB- cord-005453-4057qib7 3090 9 in in IN cord-005453-4057qib7 3090 10 the the DT cord-005453-4057qib7 3090 11 young young JJ cord-005453-4057qib7 3090 12 adult adult NN cord-005453-4057qib7 3090 13 survivors survivor NNS cord-005453-4057qib7 3090 14 compared compare VBN cord-005453-4057qib7 3090 15 to to IN cord-005453-4057qib7 3090 16 the the DT cord-005453-4057qib7 3090 17 prevalence prevalence NN cord-005453-4057qib7 3090 18 reported report VBN cord-005453-4057qib7 3090 19 for for IN cord-005453-4057qib7 3090 20 20 20 CD cord-005453-4057qib7 3090 21 - - HYPH cord-005453-4057qib7 3090 22 39year 39year CD cord-005453-4057qib7 3090 23 - - HYPH cord-005453-4057qib7 3090 24 olds old NNS cord-005453-4057qib7 3090 25 in in IN cord-005453-4057qib7 3090 26 the the DT cord-005453-4057qib7 3090 27 Nordic nordic JJ cord-005453-4057qib7 3090 28 reference reference NN cord-005453-4057qib7 3090 29 ( ( -LRB- cord-005453-4057qib7 3090 30 16 16 CD cord-005453-4057qib7 3090 31 % % NN cord-005453-4057qib7 3090 32 ) ) -RRB- cord-005453-4057qib7 3090 33 . . . cord-005453-4057qib7 3091 1 Instead instead RB cord-005453-4057qib7 3091 2 the the DT cord-005453-4057qib7 3091 3 prevalence prevalence NN cord-005453-4057qib7 3091 4 was be VBD cord-005453-4057qib7 3091 5 comparable comparable JJ cord-005453-4057qib7 3091 6 to to IN cord-005453-4057qib7 3091 7 that that DT cord-005453-4057qib7 3091 8 reported report VBN cord-005453-4057qib7 3091 9 for for IN cord-005453-4057qib7 3091 10 the the DT cord-005453-4057qib7 3091 11 50 50 CD cord-005453-4057qib7 3091 12 - - HYPH cord-005453-4057qib7 3091 13 69year 69year CD cord-005453-4057qib7 3091 14 - - HYPH cord-005453-4057qib7 3091 15 olds old NNS cord-005453-4057qib7 3091 16 ( ( -LRB- cord-005453-4057qib7 3091 17 32 32 CD cord-005453-4057qib7 3091 18 % % NN cord-005453-4057qib7 3091 19 ) ) -RRB- cord-005453-4057qib7 3091 20 . . . cord-005453-4057qib7 3092 1 Of of IN cord-005453-4057qib7 3092 2 the the DT cord-005453-4057qib7 3092 3 components component NNS cord-005453-4057qib7 3092 4 of of IN cord-005453-4057qib7 3092 5 Mets Mets NNPS cord-005453-4057qib7 3092 6 , , , cord-005453-4057qib7 3092 7 elevated elevated JJ cord-005453-4057qib7 3092 8 TG TG NNP cord-005453-4057qib7 3092 9 ( ( -LRB- cord-005453-4057qib7 3092 10 51 51 CD cord-005453-4057qib7 3092 11 % % NN cord-005453-4057qib7 3092 12 ) ) -RRB- cord-005453-4057qib7 3092 13 , , , cord-005453-4057qib7 3092 14 hypertension hypertension NN cord-005453-4057qib7 3092 15 ( ( -LRB- cord-005453-4057qib7 3092 16 47 47 CD cord-005453-4057qib7 3092 17 % % NN cord-005453-4057qib7 3092 18 ) ) -RRB- cord-005453-4057qib7 3092 19 , , , cord-005453-4057qib7 3092 20 and and CC cord-005453-4057qib7 3092 21 decreased decrease VBD cord-005453-4057qib7 3092 22 HDL HDL NNP cord-005453-4057qib7 3092 23 ( ( -LRB- cord-005453-4057qib7 3092 24 40 40 CD cord-005453-4057qib7 3092 25 % % NN cord-005453-4057qib7 3092 26 ) ) -RRB- cord-005453-4057qib7 3092 27 were be VBD cord-005453-4057qib7 3092 28 frequent frequent JJ cord-005453-4057qib7 3092 29 , , , cord-005453-4057qib7 3092 30 while while IN cord-005453-4057qib7 3092 31 FPG FPG NNP cord-005453-4057qib7 3092 32 was be VBD cord-005453-4057qib7 3092 33 elevated elevate VBN cord-005453-4057qib7 3092 34 in in IN cord-005453-4057qib7 3092 35 16 16 CD cord-005453-4057qib7 3092 36 % % NN cord-005453-4057qib7 3092 37 . . . cord-005453-4057qib7 3093 1 Importantly importantly RB cord-005453-4057qib7 3093 2 , , , cord-005453-4057qib7 3093 3 only only RB cord-005453-4057qib7 3093 4 4 4 CD cord-005453-4057qib7 3093 5 % % NN cord-005453-4057qib7 3093 6 of of IN cord-005453-4057qib7 3093 7 those those DT cord-005453-4057qib7 3093 8 with with IN cord-005453-4057qib7 3093 9 MetS MetS NNP cord-005453-4057qib7 3093 10 had have VBD cord-005453-4057qib7 3093 11 increased increase VBN cord-005453-4057qib7 3093 12 AC ac NN cord-005453-4057qib7 3093 13 and and CC cord-005453-4057qib7 3093 14 mean mean VB cord-005453-4057qib7 3093 15 BMI BMI NNP cord-005453-4057qib7 3093 16 ( ( -LRB- cord-005453-4057qib7 3093 17 23.8 23.8 CD cord-005453-4057qib7 3093 18 kg kg NNS cord-005453-4057qib7 3093 19 / / SYM cord-005453-4057qib7 3093 20 m m NN cord-005453-4057qib7 3093 21 2 2 CD cord-005453-4057qib7 3093 22 ) ) -RRB- cord-005453-4057qib7 3093 23 of of IN cord-005453-4057qib7 3093 24 the the DT cord-005453-4057qib7 3093 25 HSCT HSCT NNP cord-005453-4057qib7 3093 26 survivors survivor NNS cord-005453-4057qib7 3093 27 was be VBD cord-005453-4057qib7 3093 28 within within IN cord-005453-4057qib7 3093 29 normal normal JJ cord-005453-4057qib7 3093 30 range range NN cord-005453-4057qib7 3093 31 in in IN cord-005453-4057qib7 3093 32 contrast contrast NN cord-005453-4057qib7 3093 33 to to IN cord-005453-4057qib7 3093 34 features feature NNS cord-005453-4057qib7 3093 35 of of IN cord-005453-4057qib7 3093 36 MetS met NNS cord-005453-4057qib7 3093 37 observed observe VBN cord-005453-4057qib7 3093 38 in in IN cord-005453-4057qib7 3093 39 the the DT cord-005453-4057qib7 3093 40 background background NN cord-005453-4057qib7 3093 41 population population NN cord-005453-4057qib7 3093 42 . . . cord-005453-4057qib7 3094 1 Having have VBG cord-005453-4057qib7 3094 2 MetS MetS NNP cord-005453-4057qib7 3094 3 was be VBD cord-005453-4057qib7 3094 4 significantly significantly RB cord-005453-4057qib7 3094 5 associated associate VBN cord-005453-4057qib7 3094 6 with with IN cord-005453-4057qib7 3094 7 TBI TBI NNP cord-005453-4057qib7 3094 8 ( ( -LRB- cord-005453-4057qib7 3094 9 RR rr NN cord-005453-4057qib7 3094 10 = = SYM cord-005453-4057qib7 3094 11 7.9 7.9 CD cord-005453-4057qib7 3094 12 , , , cord-005453-4057qib7 3094 13 95%CI 95%ci CD cord-005453-4057qib7 3094 14 ( ( -LRB- cord-005453-4057qib7 3094 15 1.1 1.1 CD cord-005453-4057qib7 3094 16 - - SYM cord-005453-4057qib7 3094 17 55.3 55.3 CD cord-005453-4057qib7 3094 18 ) ) -RRB- cord-005453-4057qib7 3094 19 , , , cord-005453-4057qib7 3094 20 p=0.004 p=0.004 NNP cord-005453-4057qib7 3094 21 ) ) -RRB- cord-005453-4057qib7 3094 22 as as IN cord-005453-4057qib7 3094 23 was be VBD cord-005453-4057qib7 3094 24 the the DT cord-005453-4057qib7 3094 25 following follow VBG cord-005453-4057qib7 3094 26 single single JJ cord-005453-4057qib7 3094 27 components component NNS cord-005453-4057qib7 3094 28 of of IN cord-005453-4057qib7 3094 29 MetS met NNS cord-005453-4057qib7 3094 30 ( ( -LRB- cord-005453-4057qib7 3094 31 mean mean VB cord-005453-4057qib7 3094 32 in in IN cord-005453-4057qib7 3094 33 TBI TBI NNP cord-005453-4057qib7 3094 34 group group NN cord-005453-4057qib7 3094 35 vs. vs. FW cord-005453-4057qib7 3094 36 mean mean JJ cord-005453-4057qib7 3094 37 in in IN cord-005453-4057qib7 3094 38 non non JJ cord-005453-4057qib7 3094 39 - - JJ cord-005453-4057qib7 3094 40 TBI tbi JJ cord-005453-4057qib7 3094 41 group group NN cord-005453-4057qib7 3094 42 ) ) -RRB- cord-005453-4057qib7 3094 43 : : : cord-005453-4057qib7 3094 44 elevated elevate VBN cord-005453-4057qib7 3094 45 TG TG NNP cord-005453-4057qib7 3094 46 ( ( -LRB- cord-005453-4057qib7 3094 47 2.34 2.34 CD cord-005453-4057qib7 3094 48 mmol mmol NNP cord-005453-4057qib7 3094 49 / / SYM cord-005453-4057qib7 3094 50 L l NN cord-005453-4057qib7 3094 51 vs. vs. NN cord-005453-4057qib7 3095 1 0.93 0.93 CD cord-005453-4057qib7 3095 2 mmol/ mmol/ NNP cord-005453-4057qib7 3095 3 L L NNP cord-005453-4057qib7 3095 4 , , , cord-005453-4057qib7 3095 5 p= p= NNP cord-005453-4057qib7 3095 6 0.006 0.006 CD cord-005453-4057qib7 3095 7 ) ) -RRB- cord-005453-4057qib7 3095 8 , , , cord-005453-4057qib7 3095 9 lower low JJR cord-005453-4057qib7 3095 10 HDL HDL NNP cord-005453-4057qib7 3095 11 ( ( -LRB- cord-005453-4057qib7 3095 12 1.04 1.04 CD cord-005453-4057qib7 3095 13 mmol mmol NNP cord-005453-4057qib7 3095 14 / / SYM cord-005453-4057qib7 3095 15 L l NN cord-005453-4057qib7 3095 16 vs. vs. NN cord-005453-4057qib7 3095 17 1.38 1.38 CD cord-005453-4057qib7 3095 18 mmol mmol NNP cord-005453-4057qib7 3095 19 / / SYM cord-005453-4057qib7 3095 20 L L NNP cord-005453-4057qib7 3095 21 , , , cord-005453-4057qib7 3095 22 p=0.001 p=0.001 NNP cord-005453-4057qib7 3095 23 ) ) -RRB- cord-005453-4057qib7 3095 24 and and CC cord-005453-4057qib7 3095 25 higher high JJR cord-005453-4057qib7 3095 26 diastolic diastolic JJ cord-005453-4057qib7 3095 27 BP BP NNP cord-005453-4057qib7 3095 28 ( ( -LRB- cord-005453-4057qib7 3095 29 80 80 CD cord-005453-4057qib7 3095 30 mmHg mmHg NNS cord-005453-4057qib7 3095 31 vs. vs. NN cord-005453-4057qib7 3095 32 72 72 CD cord-005453-4057qib7 3095 33 mmHg mmHg NNS cord-005453-4057qib7 3095 34 , , , cord-005453-4057qib7 3095 35 p=0.03 p=0.03 NNP cord-005453-4057qib7 3095 36 ) ) -RRB- cord-005453-4057qib7 3095 37 . . . cord-005453-4057qib7 3096 1 MetS MetS NNP cord-005453-4057qib7 3096 2 was be VBD cord-005453-4057qib7 3096 3 only only RB cord-005453-4057qib7 3096 4 demonstrated demonstrate VBN cord-005453-4057qib7 3096 5 in in IN cord-005453-4057qib7 3096 6 one one CD cord-005453-4057qib7 3096 7 patient patient NN cord-005453-4057qib7 3096 8 who who WP cord-005453-4057qib7 3096 9 received receive VBD cord-005453-4057qib7 3096 10 non non JJ cord-005453-4057qib7 3096 11 - - JJ cord-005453-4057qib7 3096 12 TBI TBI NNP cord-005453-4057qib7 3096 13 based base VBN cord-005453-4057qib7 3096 14 conditioning conditioning NN cord-005453-4057qib7 3096 15 . . . cord-005453-4057qib7 3097 1 Sixteen sixteen CD cord-005453-4057qib7 3097 2 of of IN cord-005453-4057qib7 3097 3 49 49 CD cord-005453-4057qib7 3097 4 patients patient NNS cord-005453-4057qib7 3097 5 had have VBD cord-005453-4057qib7 3097 6 cGvHD cgvhd NN cord-005453-4057qib7 3097 7 of of IN cord-005453-4057qib7 3097 8 which which WDT cord-005453-4057qib7 3097 9 nine nine CD cord-005453-4057qib7 3097 10 were be VBD cord-005453-4057qib7 3097 11 moderate moderate JJ cord-005453-4057qib7 3097 12 to to IN cord-005453-4057qib7 3097 13 severe severe JJ cord-005453-4057qib7 3097 14 cases case NNS cord-005453-4057qib7 3097 15 , , , cord-005453-4057qib7 3097 16 but but CC cord-005453-4057qib7 3097 17 cGvHD cGvHD NNP cord-005453-4057qib7 3097 18 was be VBD cord-005453-4057qib7 3097 19 not not RB cord-005453-4057qib7 3097 20 associated associate VBN cord-005453-4057qib7 3097 21 with with IN cord-005453-4057qib7 3097 22 MetS. MetS. NNP cord-005453-4057qib7 3098 1 However however RB cord-005453-4057qib7 3098 2 , , , cord-005453-4057qib7 3098 3 low low JJ cord-005453-4057qib7 3098 4 - - HYPH cord-005453-4057qib7 3098 5 grade grade NN cord-005453-4057qib7 3098 6 inflammation inflammation NN cord-005453-4057qib7 3098 7 measured measure VBN cord-005453-4057qib7 3098 8 by by IN cord-005453-4057qib7 3098 9 hsCRP hscrp NN cord-005453-4057qib7 3098 10 was be VBD cord-005453-4057qib7 3098 11 related relate VBN cord-005453-4057qib7 3098 12 to to IN cord-005453-4057qib7 3098 13 increased increase VBN cord-005453-4057qib7 3098 14 AC ac NN cord-005453-4057qib7 3098 15 ( ( -LRB- cord-005453-4057qib7 3098 16 rho=0.41 rho=0.41 ADD cord-005453-4057qib7 3098 17 , , , cord-005453-4057qib7 3098 18 p=0.004 p=0.004 NNP cord-005453-4057qib7 3098 19 ) ) -RRB- cord-005453-4057qib7 3098 20 and and CC cord-005453-4057qib7 3098 21 TG TG NNP cord-005453-4057qib7 3098 22 ( ( -LRB- cord-005453-4057qib7 3098 23 rho=0.34 rho=0.34 '' cord-005453-4057qib7 3098 24 , , , cord-005453-4057qib7 3098 25 p=0.028 p=0.028 NN cord-005453-4057qib7 3098 26 ) ) -RRB- cord-005453-4057qib7 3098 27 . . . cord-005453-4057qib7 3099 1 Conclusions conclusion NNS cord-005453-4057qib7 3099 2 : : : cord-005453-4057qib7 3100 1 Our -PRON- PRP$ cord-005453-4057qib7 3100 2 results result NNS cord-005453-4057qib7 3100 3 indicate indicate VBP cord-005453-4057qib7 3100 4 that that IN cord-005453-4057qib7 3100 5 male male JJ cord-005453-4057qib7 3100 6 long long JJ cord-005453-4057qib7 3100 7 - - HYPH cord-005453-4057qib7 3100 8 term term NN cord-005453-4057qib7 3100 9 survivors survivor NNS cord-005453-4057qib7 3100 10 of of IN cord-005453-4057qib7 3100 11 allo allo NN cord-005453-4057qib7 3100 12 - - HYPH cord-005453-4057qib7 3100 13 HSCT HSCT NNP cord-005453-4057qib7 3100 14 during during IN cord-005453-4057qib7 3100 15 childhood childhood NN cord-005453-4057qib7 3100 16 have have VBP cord-005453-4057qib7 3100 17 a a DT cord-005453-4057qib7 3100 18 high high JJ cord-005453-4057qib7 3100 19 risk risk NN cord-005453-4057qib7 3100 20 of of IN cord-005453-4057qib7 3100 21 MetS MetS NNP cord-005453-4057qib7 3100 22 at at IN cord-005453-4057qib7 3100 23 an an DT cord-005453-4057qib7 3100 24 earlier early JJR cord-005453-4057qib7 3100 25 age age NN cord-005453-4057qib7 3100 26 than than IN cord-005453-4057qib7 3100 27 the the DT cord-005453-4057qib7 3100 28 general general JJ cord-005453-4057qib7 3100 29 population population NN cord-005453-4057qib7 3100 30 . . . cord-005453-4057qib7 3101 1 The the DT cord-005453-4057qib7 3101 2 presence presence NN cord-005453-4057qib7 3101 3 of of IN cord-005453-4057qib7 3101 4 MetS MetS NNP cord-005453-4057qib7 3101 5 despite despite IN cord-005453-4057qib7 3101 6 normal normal JJ cord-005453-4057qib7 3101 7 BMI bmi NN cord-005453-4057qib7 3101 8 in in IN cord-005453-4057qib7 3101 9 several several JJ cord-005453-4057qib7 3101 10 patients patient NNS cord-005453-4057qib7 3101 11 suggests suggest VBZ cord-005453-4057qib7 3101 12 unconventional unconventional JJ cord-005453-4057qib7 3101 13 etiologies etiology NNS cord-005453-4057qib7 3101 14 like like IN cord-005453-4057qib7 3101 15 the the DT cord-005453-4057qib7 3101 16 effect effect NN cord-005453-4057qib7 3101 17 of of IN cord-005453-4057qib7 3101 18 TBI TBI NNP cord-005453-4057qib7 3101 19 and and CC cord-005453-4057qib7 3101 20 low low JJ cord-005453-4057qib7 3101 21 - - HYPH cord-005453-4057qib7 3101 22 grade grade NN cord-005453-4057qib7 3101 23 inflammation inflammation NN cord-005453-4057qib7 3101 24 . . . cord-005453-4057qib7 3102 1 Disclosure disclosure NN cord-005453-4057qib7 3102 2 : : : cord-005453-4057qib7 3102 3 Nothing nothing NN cord-005453-4057qib7 3102 4 to to TO cord-005453-4057qib7 3102 5 declare declare VB cord-005453-4057qib7 3102 6 . . . cord-005453-4057qib7 3103 1 Results result NNS cord-005453-4057qib7 3103 2 : : : cord-005453-4057qib7 3104 1 This this DT cord-005453-4057qib7 3104 2 survey survey NN cord-005453-4057qib7 3104 3 was be VBD cord-005453-4057qib7 3104 4 completed complete VBN cord-005453-4057qib7 3104 5 by by IN cord-005453-4057qib7 3104 6 transplant transplant NN cord-005453-4057qib7 3104 7 directors director NNS cord-005453-4057qib7 3104 8 ( ( -LRB- cord-005453-4057qib7 3104 9 46 46 CD cord-005453-4057qib7 3104 10 % % NN cord-005453-4057qib7 3104 11 ) ) -RRB- cord-005453-4057qib7 3104 12 , , , cord-005453-4057qib7 3104 13 transplant transplant NN cord-005453-4057qib7 3104 14 consultants consultant NNS cord-005453-4057qib7 3104 15 ( ( -LRB- cord-005453-4057qib7 3104 16 41 41 CD cord-005453-4057qib7 3104 17 % % NN cord-005453-4057qib7 3104 18 ) ) -RRB- cord-005453-4057qib7 3104 19 , , , cord-005453-4057qib7 3104 20 nonconsultant nonconsultant JJ cord-005453-4057qib7 3104 21 grade grade NN cord-005453-4057qib7 3104 22 physicians physician NNS cord-005453-4057qib7 3104 23 ( ( -LRB- cord-005453-4057qib7 3104 24 8 8 CD cord-005453-4057qib7 3104 25 % % NN cord-005453-4057qib7 3104 26 ) ) -RRB- cord-005453-4057qib7 3104 27 , , , cord-005453-4057qib7 3104 28 HSCT HSCT NNP cord-005453-4057qib7 3104 29 clinical clinical JJ cord-005453-4057qib7 3104 30 nurses nurse NNS cord-005453-4057qib7 3104 31 specialists specialist NNS cord-005453-4057qib7 3104 32 ( ( -LRB- cord-005453-4057qib7 3104 33 CNS CNS NNP cord-005453-4057qib7 3104 34 ) ) -RRB- cord-005453-4057qib7 3104 35 ( ( -LRB- cord-005453-4057qib7 3104 36 3 3 CD cord-005453-4057qib7 3104 37 % % NN cord-005453-4057qib7 3104 38 ) ) -RRB- cord-005453-4057qib7 3104 39 and and CC cord-005453-4057qib7 3104 40 other other JJ cord-005453-4057qib7 3104 41 ( ( -LRB- cord-005453-4057qib7 3104 42 2 2 CD cord-005453-4057qib7 3104 43 % % NN cord-005453-4057qib7 3104 44 ) ) -RRB- cord-005453-4057qib7 3104 45 from from IN cord-005453-4057qib7 3104 46 114 114 CD cord-005453-4057qib7 3104 47 centres centre NNS cord-005453-4057qib7 3104 48 in in IN cord-005453-4057qib7 3104 49 24 24 CD cord-005453-4057qib7 3104 50 countries country NNS cord-005453-4057qib7 3104 51 . . . cord-005453-4057qib7 3105 1 58 58 CD cord-005453-4057qib7 3105 2 % % NN cord-005453-4057qib7 3105 3 of of IN cord-005453-4057qib7 3105 4 the the DT cord-005453-4057qib7 3105 5 centres centre NNS cord-005453-4057qib7 3105 6 are be VBP cord-005453-4057qib7 3105 7 adult adult NN cord-005453-4057qib7 3105 8 - - HYPH cord-005453-4057qib7 3105 9 only only RB cord-005453-4057qib7 3105 10 , , , cord-005453-4057qib7 3105 11 21 21 CD cord-005453-4057qib7 3105 12 % % NN cord-005453-4057qib7 3105 13 paediatric paediatric JJ cord-005453-4057qib7 3105 14 - - HYPH cord-005453-4057qib7 3105 15 only only RB cord-005453-4057qib7 3105 16 and and CC cord-005453-4057qib7 3105 17 21 21 CD cord-005453-4057qib7 3105 18 % % NN cord-005453-4057qib7 3105 19 treat treat NN cord-005453-4057qib7 3105 20 adult adult NN cord-005453-4057qib7 3105 21 and and CC cord-005453-4057qib7 3105 22 paediatric paediatric JJ cord-005453-4057qib7 3105 23 patients patient NNS cord-005453-4057qib7 3105 24 ( ( -LRB- cord-005453-4057qib7 3105 25 mixed mixed JJ cord-005453-4057qib7 3105 26 centres centre NNS cord-005453-4057qib7 3105 27 ) ) -RRB- cord-005453-4057qib7 3105 28 . . . cord-005453-4057qib7 3106 1 46 46 CD cord-005453-4057qib7 3106 2 % % NN cord-005453-4057qib7 3106 3 are be VBP cord-005453-4057qib7 3106 4 located locate VBN cord-005453-4057qib7 3106 5 higher high JJR cord-005453-4057qib7 3106 6 than than IN cord-005453-4057qib7 3106 7 50 50 CD cord-005453-4057qib7 3106 8 degrees degree NNS cord-005453-4057qib7 3106 9 latitude latitude NN cord-005453-4057qib7 3106 10 ( ( -LRB- cord-005453-4057qib7 3106 11 northern northern JJ cord-005453-4057qib7 3106 12 countries country NNS cord-005453-4057qib7 3106 13 ) ) -RRB- cord-005453-4057qib7 3106 14 and and CC cord-005453-4057qib7 3106 15 54 54 CD cord-005453-4057qib7 3106 16 % % NN cord-005453-4057qib7 3106 17 lower low JJR cord-005453-4057qib7 3106 18 than than IN cord-005453-4057qib7 3106 19 this this DT cord-005453-4057qib7 3106 20 latitude latitude NN cord-005453-4057qib7 3106 21 ( ( -LRB- cord-005453-4057qib7 3106 22 southern southern JJ cord-005453-4057qib7 3106 23 countries country NNS cord-005453-4057qib7 3106 24 ) ) -RRB- cord-005453-4057qib7 3106 25 . . . cord-005453-4057qib7 3107 1 At at IN cord-005453-4057qib7 3107 2 the the DT cord-005453-4057qib7 3107 3 time time NN cord-005453-4057qib7 3107 4 of of IN cord-005453-4057qib7 3107 5 the the DT cord-005453-4057qib7 3107 6 survey survey NN cord-005453-4057qib7 3107 7 84 84 CD cord-005453-4057qib7 3107 8 % % NN cord-005453-4057qib7 3107 9 were be VBD cord-005453-4057qib7 3107 10 members member NNS cord-005453-4057qib7 3107 11 of of IN cord-005453-4057qib7 3107 12 the the DT cord-005453-4057qib7 3107 13 European European NNP cord-005453-4057qib7 3107 14 Union Union NNP cord-005453-4057qib7 3107 15 ( ( -LRB- cord-005453-4057qib7 3107 16 EU EU NNP cord-005453-4057qib7 3107 17 ) ) -RRB- cord-005453-4057qib7 3107 18 . . . cord-005453-4057qib7 3108 1 Measurement measurement NN cord-005453-4057qib7 3108 2 of of IN cord-005453-4057qib7 3108 3 serum serum NN cord-005453-4057qib7 3108 4 VD vd NN cord-005453-4057qib7 3108 5 is be VBZ cord-005453-4057qib7 3108 6 routinely routinely RB cord-005453-4057qib7 3108 7 performed perform VBN cord-005453-4057qib7 3108 8 in in IN cord-005453-4057qib7 3108 9 47 47 CD cord-005453-4057qib7 3108 10 % % NN cord-005453-4057qib7 3108 11 of of IN cord-005453-4057qib7 3108 12 the the DT cord-005453-4057qib7 3108 13 centres centre NNS cord-005453-4057qib7 3108 14 prior prior RB cord-005453-4057qib7 3108 15 and and CC cord-005453-4057qib7 3108 16 in in IN cord-005453-4057qib7 3108 17 70 70 CD cord-005453-4057qib7 3108 18 % % NN cord-005453-4057qib7 3108 19 after after IN cord-005453-4057qib7 3108 20 allogeneic allogeneic NN cord-005453-4057qib7 3108 21 HSCT HSCT NNP cord-005453-4057qib7 3108 22 . . . cord-005453-4057qib7 3109 1 The the DT cord-005453-4057qib7 3109 2 main main JJ cord-005453-4057qib7 3109 3 clinical clinical JJ cord-005453-4057qib7 3109 4 indications indication NNS cord-005453-4057qib7 3109 5 are be VBP cord-005453-4057qib7 3109 6 known know VBN cord-005453-4057qib7 3109 7 osteopaenia osteopaenia NNP cord-005453-4057qib7 3109 8 / / SYM cord-005453-4057qib7 3109 9 osteoporosis osteoporosis NN cord-005453-4057qib7 3109 10 ( ( -LRB- cord-005453-4057qib7 3109 11 86 86 CD cord-005453-4057qib7 3109 12 % % NN cord-005453-4057qib7 3109 13 ) ) -RRB- cord-005453-4057qib7 3109 14 , , , cord-005453-4057qib7 3109 15 previous previous JJ cord-005453-4057qib7 3109 16 fracture fracture NN cord-005453-4057qib7 3109 17 ( ( -LRB- cord-005453-4057qib7 3109 18 71 71 CD cord-005453-4057qib7 3109 19 % % NN cord-005453-4057qib7 3109 20 ) ) -RRB- cord-005453-4057qib7 3109 21 , , , cord-005453-4057qib7 3109 22 treatment treatment NN cord-005453-4057qib7 3109 23 with with IN cord-005453-4057qib7 3109 24 steroids steroid NNS cord-005453-4057qib7 3109 25 ( ( -LRB- cord-005453-4057qib7 3109 26 68 68 CD cord-005453-4057qib7 3109 27 % % NN cord-005453-4057qib7 3109 28 ) ) -RRB- cord-005453-4057qib7 3109 29 , , , cord-005453-4057qib7 3109 30 premature premature JJ cord-005453-4057qib7 3109 31 menopause menopause NN cord-005453-4057qib7 3109 32 ( ( -LRB- cord-005453-4057qib7 3109 33 46 46 CD cord-005453-4057qib7 3109 34 % % NN cord-005453-4057qib7 3109 35 ) ) -RRB- cord-005453-4057qib7 3109 36 and and CC cord-005453-4057qib7 3109 37 established establish VBD cord-005453-4057qib7 3109 38 menopause menopause NN cord-005453-4057qib7 3109 39 ( ( -LRB- cord-005453-4057qib7 3109 40 32 32 CD cord-005453-4057qib7 3109 41 % % NN cord-005453-4057qib7 3109 42 ) ) -RRB- cord-005453-4057qib7 3109 43 . . . cord-005453-4057qib7 3110 1 Monitoring monitoring NN cord-005453-4057qib7 3110 2 occurs occur VBZ cord-005453-4057qib7 3110 3 every every DT cord-005453-4057qib7 3110 4 3 3 CD cord-005453-4057qib7 3110 5 months month NNS cord-005453-4057qib7 3110 6 ( ( -LRB- cord-005453-4057qib7 3110 7 39 39 CD cord-005453-4057qib7 3110 8 % % NN cord-005453-4057qib7 3110 9 ) ) -RRB- cord-005453-4057qib7 3110 10 , , , cord-005453-4057qib7 3110 11 every every DT cord-005453-4057qib7 3110 12 6 6 CD cord-005453-4057qib7 3110 13 months month NNS cord-005453-4057qib7 3110 14 ( ( -LRB- cord-005453-4057qib7 3110 15 24 24 CD cord-005453-4057qib7 3110 16 % % NN cord-005453-4057qib7 3110 17 ) ) -RRB- cord-005453-4057qib7 3110 18 , , , cord-005453-4057qib7 3110 19 once once RB cord-005453-4057qib7 3110 20 a a DT cord-005453-4057qib7 3110 21 year year NN cord-005453-4057qib7 3110 22 ( ( -LRB- cord-005453-4057qib7 3110 23 18 18 CD cord-005453-4057qib7 3110 24 % % NN cord-005453-4057qib7 3110 25 ) ) -RRB- cord-005453-4057qib7 3110 26 or or CC cord-005453-4057qib7 3110 27 at at IN cord-005453-4057qib7 3110 28 other other JJ cord-005453-4057qib7 3110 29 time time NN cord-005453-4057qib7 3110 30 - - HYPH cord-005453-4057qib7 3110 31 points point NNS cord-005453-4057qib7 3110 32 ( ( -LRB- cord-005453-4057qib7 3110 33 19 19 CD cord-005453-4057qib7 3110 34 % % NN cord-005453-4057qib7 3110 35 ) ) -RRB- cord-005453-4057qib7 3110 36 . . . cord-005453-4057qib7 3111 1 In in IN cord-005453-4057qib7 3111 2 this this DT cord-005453-4057qib7 3111 3 regard regard NN cord-005453-4057qib7 3111 4 , , , cord-005453-4057qib7 3111 5 seasonality seasonality NN cord-005453-4057qib7 3111 6 is be VBZ cord-005453-4057qib7 3111 7 not not RB cord-005453-4057qib7 3111 8 taken take VBN cord-005453-4057qib7 3111 9 into into IN cord-005453-4057qib7 3111 10 account account NN cord-005453-4057qib7 3111 11 in in IN cord-005453-4057qib7 3111 12 the the DT cord-005453-4057qib7 3111 13 majority majority NN cord-005453-4057qib7 3111 14 of of IN cord-005453-4057qib7 3111 15 the the DT cord-005453-4057qib7 3111 16 centres centre NNS cord-005453-4057qib7 3111 17 ( ( -LRB- cord-005453-4057qib7 3111 18 94 94 CD cord-005453-4057qib7 3111 19 % % NN cord-005453-4057qib7 3111 20 ) ) -RRB- cord-005453-4057qib7 3111 21 . . . cord-005453-4057qib7 3112 1 Local local JJ cord-005453-4057qib7 3112 2 and and CC cord-005453-4057qib7 3112 3 national national JJ cord-005453-4057qib7 3112 4 / / SYM cord-005453-4057qib7 3112 5 international international JJ cord-005453-4057qib7 3112 6 guidelines guideline NNS cord-005453-4057qib7 3112 7 ( ( -LRB- cord-005453-4057qib7 3112 8 NICE NICE NNP cord-005453-4057qib7 3112 9 ) ) -RRB- cord-005453-4057qib7 3112 10 are be VBP cord-005453-4057qib7 3112 11 only only RB cord-005453-4057qib7 3112 12 followed follow VBN cord-005453-4057qib7 3112 13 by by IN cord-005453-4057qib7 3112 14 19 19 CD cord-005453-4057qib7 3112 15 % % NN cord-005453-4057qib7 3112 16 and and CC cord-005453-4057qib7 3112 17 18 18 CD cord-005453-4057qib7 3112 18 % % NN cord-005453-4057qib7 3112 19 of of IN cord-005453-4057qib7 3112 20 the the DT cord-005453-4057qib7 3112 21 centres centre NNS cord-005453-4057qib7 3112 22 , , , cord-005453-4057qib7 3112 23 respectively respectively RB cord-005453-4057qib7 3112 24 . . . cord-005453-4057qib7 3113 1 The the DT cord-005453-4057qib7 3113 2 most most RBS cord-005453-4057qib7 3113 3 common common JJ cord-005453-4057qib7 3113 4 cut cut VBN cord-005453-4057qib7 3113 5 - - HYPH cord-005453-4057qib7 3113 6 off off RP cord-005453-4057qib7 3113 7 value value NN cord-005453-4057qib7 3113 8 of of IN cord-005453-4057qib7 3113 9 serum serum NN cord-005453-4057qib7 3113 10 VD vd NN cord-005453-4057qib7 3113 11 for for IN cord-005453-4057qib7 3113 12 commencing commence VBG cord-005453-4057qib7 3113 13 on on IN cord-005453-4057qib7 3113 14 replacement replacement NN cord-005453-4057qib7 3113 15 is be VBZ cord-005453-4057qib7 3113 16 50 50 CD cord-005453-4057qib7 3113 17 nmol nmol JJ cord-005453-4057qib7 3113 18 / / SYM cord-005453-4057qib7 3113 19 L l NN cord-005453-4057qib7 3113 20 ( ( -LRB- cord-005453-4057qib7 3113 21 32 32 CD cord-005453-4057qib7 3113 22 % % NN cord-005453-4057qib7 3113 23 ) ) -RRB- cord-005453-4057qib7 3113 24 . . . cord-005453-4057qib7 3114 1 Northern northern JJ cord-005453-4057qib7 3114 2 countries country NNS cord-005453-4057qib7 3114 3 tend tend VBP cord-005453-4057qib7 3114 4 to to TO cord-005453-4057qib7 3114 5 use use VB cord-005453-4057qib7 3114 6 values value NNS cord-005453-4057qib7 3114 7 of of IN cord-005453-4057qib7 3114 8 ≥75 ≥75 NNP cord-005453-4057qib7 3114 9 nmol nmol NNP cord-005453-4057qib7 3114 10 / / SYM cord-005453-4057qib7 3114 11 L L NNP cord-005453-4057qib7 3114 12 whereas whereas IN cord-005453-4057qib7 3114 13 southern southern JJ cord-005453-4057qib7 3114 14 countries country NNS cord-005453-4057qib7 3114 15 ≤50 ≤50 NNP cord-005453-4057qib7 3115 1 nmol nmol NNP cord-005453-4057qib7 3115 2 / / SYM cord-005453-4057qib7 3115 3 L. L. NNP cord-005453-4057qib7 3116 1 15 15 CD cord-005453-4057qib7 3116 2 % % NN cord-005453-4057qib7 3116 3 do do VBP cord-005453-4057qib7 3116 4 not not RB cord-005453-4057qib7 3116 5 use use VB cord-005453-4057qib7 3116 6 cut cut VB cord-005453-4057qib7 3116 7 - - HYPH cord-005453-4057qib7 3116 8 off off RP cord-005453-4057qib7 3116 9 values value NNS cord-005453-4057qib7 3116 10 . . . cord-005453-4057qib7 3117 1 Following follow VBG cord-005453-4057qib7 3117 2 HSCT HSCT NNP cord-005453-4057qib7 3117 3 , , , cord-005453-4057qib7 3117 4 83 83 CD cord-005453-4057qib7 3117 5 % % NN cord-005453-4057qib7 3117 6 of of IN cord-005453-4057qib7 3117 7 centres centre NNS cord-005453-4057qib7 3117 8 prescribe prescribe VBP cord-005453-4057qib7 3117 9 VD vd NN cord-005453-4057qib7 3117 10 supplements supplement NNS cord-005453-4057qib7 3117 11 to to TO cord-005453-4057qib7 3117 12 maintain maintain VB cord-005453-4057qib7 3117 13 calcium calcium NN cord-005453-4057qib7 3117 14 metabolism metabolism NN cord-005453-4057qib7 3117 15 and and CC cord-005453-4057qib7 3117 16 bone bone NN cord-005453-4057qib7 3117 17 health health NN cord-005453-4057qib7 3117 18 ( ( -LRB- cord-005453-4057qib7 3117 19 92 92 CD cord-005453-4057qib7 3117 20 % % NN cord-005453-4057qib7 3117 21 ) ) -RRB- cord-005453-4057qib7 3117 22 , , , cord-005453-4057qib7 3117 23 enhance enhance VB cord-005453-4057qib7 3117 24 immune immune JJ cord-005453-4057qib7 3117 25 reconstitution reconstitution NN cord-005453-4057qib7 3117 26 post post NN cord-005453-4057qib7 3117 27 - - JJ cord-005453-4057qib7 3117 28 HSCT HSCT NNP cord-005453-4057qib7 3117 29 ( ( -LRB- cord-005453-4057qib7 3117 30 24 24 CD cord-005453-4057qib7 3117 31 % % NN cord-005453-4057qib7 3117 32 ) ) -RRB- cord-005453-4057qib7 3117 33 , , , cord-005453-4057qib7 3117 34 GvHD GvHD NNP cord-005453-4057qib7 3117 35 prevention prevention NN cord-005453-4057qib7 3117 36 ( ( -LRB- cord-005453-4057qib7 3117 37 17 17 CD cord-005453-4057qib7 3117 38 % % NN cord-005453-4057qib7 3117 39 ) ) -RRB- cord-005453-4057qib7 3117 40 , , , cord-005453-4057qib7 3117 41 enhance enhance VB cord-005453-4057qib7 3117 42 immune immune JJ cord-005453-4057qib7 3117 43 - - HYPH cord-005453-4057qib7 3117 44 suppression suppression NN cord-005453-4057qib7 3117 45 to to TO cord-005453-4057qib7 3117 46 treat treat VB cord-005453-4057qib7 3117 47 GvHD GvHD NNP cord-005453-4057qib7 3117 48 ( ( -LRB- cord-005453-4057qib7 3117 49 10 10 CD cord-005453-4057qib7 3117 50 % % NN cord-005453-4057qib7 3117 51 ) ) -RRB- cord-005453-4057qib7 3117 52 , , , cord-005453-4057qib7 3117 53 treat treat VB cord-005453-4057qib7 3117 54 depression depression NN cord-005453-4057qib7 3117 55 / / SYM cord-005453-4057qib7 3117 56 fatigue fatigue NN cord-005453-4057qib7 3117 57 ( ( -LRB- cord-005453-4057qib7 3117 58 3 3 CD cord-005453-4057qib7 3117 59 % % NN cord-005453-4057qib7 3117 60 ) ) -RRB- cord-005453-4057qib7 3117 61 and and CC cord-005453-4057qib7 3117 62 reduce reduce VB cord-005453-4057qib7 3117 63 relapse relapse NN cord-005453-4057qib7 3117 64 risk risk NN cord-005453-4057qib7 3117 65 2 2 CD cord-005453-4057qib7 3117 66 % % NN cord-005453-4057qib7 3117 67 . . . cord-005453-4057qib7 3118 1 A a DT cord-005453-4057qib7 3118 2 " " `` cord-005453-4057qib7 3118 3 loading loading NN cord-005453-4057qib7 3118 4 " " '' cord-005453-4057qib7 3118 5 dose dose NN cord-005453-4057qib7 3118 6 is be VBZ cord-005453-4057qib7 3118 7 administrated administrate VBN cord-005453-4057qib7 3118 8 in in IN cord-005453-4057qib7 3118 9 30 30 CD cord-005453-4057qib7 3118 10 % % NN cord-005453-4057qib7 3118 11 ( ( -LRB- cord-005453-4057qib7 3118 12 54 54 CD cord-005453-4057qib7 3118 13 % % NN cord-005453-4057qib7 3118 14 adult adult NN cord-005453-4057qib7 3118 15 , , , cord-005453-4057qib7 3118 16 25 25 CD cord-005453-4057qib7 3118 17 % % NN cord-005453-4057qib7 3118 18 mixed mixed JJ cord-005453-4057qib7 3118 19 and and CC cord-005453-4057qib7 3118 20 22 22 CD cord-005453-4057qib7 3118 21 % % NN cord-005453-4057qib7 3118 22 paediatric paediatric JJ cord-005453-4057qib7 3118 23 ) ) -RRB- cord-005453-4057qib7 3118 24 , , , cord-005453-4057qib7 3118 25 with with IN cord-005453-4057qib7 3118 26 a a DT cord-005453-4057qib7 3118 27 mean mean JJ cord-005453-4057qib7 3118 28 duration duration NN cord-005453-4057qib7 3118 29 of of IN cord-005453-4057qib7 3118 30 4 4 CD cord-005453-4057qib7 3118 31 weeks week NNS cord-005453-4057qib7 3118 32 . . . cord-005453-4057qib7 3119 1 The the DT cord-005453-4057qib7 3119 2 median median JJ cord-005453-4057qib7 3119 3 daily daily JJ cord-005453-4057qib7 3119 4 loading loading NN cord-005453-4057qib7 3119 5 dose dose NN cord-005453-4057qib7 3119 6 is be VBZ cord-005453-4057qib7 3119 7 2,000 2,000 CD cord-005453-4057qib7 3119 8 IU IU NNP cord-005453-4057qib7 3119 9 ( ( -LRB- cord-005453-4057qib7 3119 10 286 286 CD cord-005453-4057qib7 3119 11 - - SYM cord-005453-4057qib7 3119 12 20,000 20,000 CD cord-005453-4057qib7 3119 13 ) ) -RRB- cord-005453-4057qib7 3119 14 . . . cord-005453-4057qib7 3120 1 The the DT cord-005453-4057qib7 3120 2 median median JJ cord-005453-4057qib7 3120 3 " " `` cord-005453-4057qib7 3120 4 maintenance maintenance NN cord-005453-4057qib7 3120 5 " " '' cord-005453-4057qib7 3120 6 daily daily JJ cord-005453-4057qib7 3120 7 dose dose NN cord-005453-4057qib7 3120 8 is be VBZ cord-005453-4057qib7 3120 9 800 800 CD cord-005453-4057qib7 3120 10 IU IU NNP cord-005453-4057qib7 3120 11 ( ( -LRB- cord-005453-4057qib7 3120 12 67 67 CD cord-005453-4057qib7 3120 13 - - SYM cord-005453-4057qib7 3120 14 10,000 10,000 CD cord-005453-4057qib7 3120 15 ) ) -RRB- cord-005453-4057qib7 3120 16 . . . cord-005453-4057qib7 3121 1 There there EX cord-005453-4057qib7 3121 2 are be VBP cord-005453-4057qib7 3121 3 not not RB cord-005453-4057qib7 3121 4 remarkable remarkable JJ cord-005453-4057qib7 3121 5 differences difference NNS cord-005453-4057qib7 3121 6 between between IN cord-005453-4057qib7 3121 7 adult adult NN cord-005453-4057qib7 3121 8 and and CC cord-005453-4057qib7 3121 9 paediatric paediatric JJ cord-005453-4057qib7 3121 10 centres centre NNS cord-005453-4057qib7 3121 11 or or CC cord-005453-4057qib7 3121 12 northern northern JJ cord-005453-4057qib7 3121 13 and and CC cord-005453-4057qib7 3121 14 southern southern JJ cord-005453-4057qib7 3121 15 countries country NNS cord-005453-4057qib7 3121 16 . . . cord-005453-4057qib7 3122 1 VD VD NNP cord-005453-4057qib7 3122 2 replacement replacement NN cord-005453-4057qib7 3122 3 is be VBZ cord-005453-4057qib7 3122 4 prescribed prescribe VBN cord-005453-4057qib7 3122 5 by by IN cord-005453-4057qib7 3122 6 transplant transplant NN cord-005453-4057qib7 3122 7 physicians physician NNS cord-005453-4057qib7 3122 8 ( ( -LRB- cord-005453-4057qib7 3122 9 75 75 CD cord-005453-4057qib7 3122 10 % % NN cord-005453-4057qib7 3122 11 ) ) -RRB- cord-005453-4057qib7 3122 12 , , , cord-005453-4057qib7 3122 13 family family NN cord-005453-4057qib7 3122 14 physicians physician NNS cord-005453-4057qib7 3122 15 ( ( -LRB- cord-005453-4057qib7 3122 16 10 10 CD cord-005453-4057qib7 3122 17 % % NN cord-005453-4057qib7 3122 18 ) ) -RRB- cord-005453-4057qib7 3122 19 , , , cord-005453-4057qib7 3122 20 endocrinologists endocrinologist NNS cord-005453-4057qib7 3122 21 ( ( -LRB- cord-005453-4057qib7 3122 22 3 3 CD cord-005453-4057qib7 3122 23 % % NN cord-005453-4057qib7 3122 24 ) ) -RRB- cord-005453-4057qib7 3122 25 , , , cord-005453-4057qib7 3122 26 CNS CNS NNP cord-005453-4057qib7 3122 27 ( ( -LRB- cord-005453-4057qib7 3122 28 3 3 CD cord-005453-4057qib7 3122 29 % % NN cord-005453-4057qib7 3122 30 ) ) -RRB- cord-005453-4057qib7 3122 31 , , , cord-005453-4057qib7 3122 32 others other NNS cord-005453-4057qib7 3122 33 ( ( -LRB- cord-005453-4057qib7 3122 34 4 4 CD cord-005453-4057qib7 3122 35 % % NN cord-005453-4057qib7 3122 36 ) ) -RRB- cord-005453-4057qib7 3122 37 and and CC cord-005453-4057qib7 3122 38 in in IN cord-005453-4057qib7 3122 39 5 5 CD cord-005453-4057qib7 3122 40 % % NN cord-005453-4057qib7 3122 41 of of IN cord-005453-4057qib7 3122 42 the the DT cord-005453-4057qib7 3122 43 centres centre NNS cord-005453-4057qib7 3122 44 , , , cord-005453-4057qib7 3122 45 patients patient NNS cord-005453-4057qib7 3122 46 are be VBP cord-005453-4057qib7 3122 47 advised advise VBN cord-005453-4057qib7 3122 48 to to TO cord-005453-4057qib7 3122 49 buy buy VB cord-005453-4057qib7 3122 50 it -PRON- PRP cord-005453-4057qib7 3122 51 over over IN cord-005453-4057qib7 3122 52 - - HYPH cord-005453-4057qib7 3122 53 the the DT cord-005453-4057qib7 3122 54 - - HYPH cord-005453-4057qib7 3122 55 counter counter NN cord-005453-4057qib7 3122 56 . . . cord-005453-4057qib7 3123 1 VD VD NNP cord-005453-4057qib7 3123 2 is be VBZ cord-005453-4057qib7 3123 3 prescribed prescribe VBN cord-005453-4057qib7 3123 4 combined combine VBN cord-005453-4057qib7 3123 5 with with IN cord-005453-4057qib7 3123 6 calcium calcium NN cord-005453-4057qib7 3123 7 carbonate carbonate NN cord-005453-4057qib7 3123 8 in in IN cord-005453-4057qib7 3123 9 52 52 CD cord-005453-4057qib7 3123 10 % % NN cord-005453-4057qib7 3123 11 and and CC cord-005453-4057qib7 3123 12 alone alone RB cord-005453-4057qib7 3123 13 in in IN cord-005453-4057qib7 3123 14 48 48 CD cord-005453-4057qib7 3123 15 % % NN cord-005453-4057qib7 3123 16 of of IN cord-005453-4057qib7 3123 17 the the DT cord-005453-4057qib7 3123 18 centres centre NNS cord-005453-4057qib7 3123 19 . . . cord-005453-4057qib7 3124 1 It -PRON- PRP cord-005453-4057qib7 3124 2 is be VBZ cord-005453-4057qib7 3124 3 eventually eventually RB cord-005453-4057qib7 3124 4 discontinued discontinue VBN cord-005453-4057qib7 3124 5 by by IN cord-005453-4057qib7 3124 6 69 69 CD cord-005453-4057qib7 3124 7 % % NN cord-005453-4057qib7 3124 8 of of IN cord-005453-4057qib7 3124 9 the the DT cord-005453-4057qib7 3124 10 centres centre NNS cord-005453-4057qib7 3124 11 when when WRB cord-005453-4057qib7 3124 12 therapeutical therapeutical JJ cord-005453-4057qib7 3124 13 levels level NNS cord-005453-4057qib7 3124 14 of of IN cord-005453-4057qib7 3124 15 VD VD NNP cord-005453-4057qib7 3124 16 are be VBP cord-005453-4057qib7 3124 17 reached reach VBN cord-005453-4057qib7 3124 18 ( ( -LRB- cord-005453-4057qib7 3124 19 69 69 CD cord-005453-4057qib7 3124 20 % % NN cord-005453-4057qib7 3124 21 ) ) -RRB- cord-005453-4057qib7 3124 22 , , , cord-005453-4057qib7 3124 23 DEXA DEXA NNP cord-005453-4057qib7 3124 24 scan scan JJ cord-005453-4057qib7 3124 25 returns return NNS cord-005453-4057qib7 3124 26 to to IN cord-005453-4057qib7 3124 27 normal normal JJ cord-005453-4057qib7 3124 28 ( ( -LRB- cord-005453-4057qib7 3124 29 12 12 CD cord-005453-4057qib7 3124 30 % % NN cord-005453-4057qib7 3124 31 ) ) -RRB- cord-005453-4057qib7 3124 32 and and CC cord-005453-4057qib7 3124 33 symptomatic symptomatic JJ cord-005453-4057qib7 3124 34 improvement improvement NN cord-005453-4057qib7 3124 35 ( ( -LRB- cord-005453-4057qib7 3124 36 9 9 CD cord-005453-4057qib7 3124 37 % % NN cord-005453-4057qib7 3124 38 ) ) -RRB- cord-005453-4057qib7 3124 39 . . . cord-005453-4057qib7 3125 1 Conclusions conclusion NNS cord-005453-4057qib7 3125 2 : : : cord-005453-4057qib7 3126 1 This this DT cord-005453-4057qib7 3126 2 survey survey NN cord-005453-4057qib7 3126 3 has have VBZ cord-005453-4057qib7 3126 4 demonstrated demonstrate VBN cord-005453-4057qib7 3126 5 discrepancies discrepancy NNS cord-005453-4057qib7 3126 6 in in IN cord-005453-4057qib7 3126 7 monitoring monitoring NN cord-005453-4057qib7 3126 8 and and CC cord-005453-4057qib7 3126 9 replacement replacement NN cord-005453-4057qib7 3126 10 of of IN cord-005453-4057qib7 3126 11 VD VD NNP cord-005453-4057qib7 3126 12 across across IN cord-005453-4057qib7 3126 13 EBMT EBMT NNP cord-005453-4057qib7 3126 14 allogeneic allogeneic IN cord-005453-4057qib7 3126 15 HSCT HSCT NNP cord-005453-4057qib7 3126 16 Programmes Programmes NNP cord-005453-4057qib7 3126 17 . . . cord-005453-4057qib7 3127 1 Although although IN cord-005453-4057qib7 3127 2 awareness awareness NN cord-005453-4057qib7 3127 3 has have VBZ cord-005453-4057qib7 3127 4 arisen arise VBN cord-005453-4057qib7 3127 5 over over IN cord-005453-4057qib7 3127 6 the the DT cord-005453-4057qib7 3127 7 last last JJ cord-005453-4057qib7 3127 8 decade decade NN cord-005453-4057qib7 3127 9 , , , cord-005453-4057qib7 3127 10 there there EX cord-005453-4057qib7 3127 11 is be VBZ cord-005453-4057qib7 3127 12 still still RB cord-005453-4057qib7 3127 13 lack lack NN cord-005453-4057qib7 3127 14 of of IN cord-005453-4057qib7 3127 15 evidence evidence NN cord-005453-4057qib7 3127 16 about about IN cord-005453-4057qib7 3127 17 the the DT cord-005453-4057qib7 3127 18 optimal optimal JJ cord-005453-4057qib7 3127 19 levels level NNS cord-005453-4057qib7 3127 20 of of IN cord-005453-4057qib7 3127 21 VD VD NNP cord-005453-4057qib7 3127 22 required require VBN cord-005453-4057qib7 3127 23 for for IN cord-005453-4057qib7 3127 24 immunemodulation immunemodulation NN cord-005453-4057qib7 3127 25 post post JJ cord-005453-4057qib7 3127 26 - - JJ cord-005453-4057qib7 3127 27 HSCT HSCT NNP cord-005453-4057qib7 3127 28 . . . cord-005453-4057qib7 3128 1 This this DT cord-005453-4057qib7 3128 2 survey survey NN cord-005453-4057qib7 3128 3 emphasises emphasise VBZ cord-005453-4057qib7 3128 4 the the DT cord-005453-4057qib7 3128 5 need need NN cord-005453-4057qib7 3128 6 for for IN cord-005453-4057qib7 3128 7 specific specific JJ cord-005453-4057qib7 3128 8 guidelines guideline NNS cord-005453-4057qib7 3128 9 to to TO cord-005453-4057qib7 3128 10 harmonise harmonise VB cord-005453-4057qib7 3128 11 the the DT cord-005453-4057qib7 3128 12 current current JJ cord-005453-4057qib7 3128 13 management management NN cord-005453-4057qib7 3128 14 of of IN cord-005453-4057qib7 3128 15 VD VD NNP cord-005453-4057qib7 3128 16 deficiency deficiency NN cord-005453-4057qib7 3128 17 in in IN cord-005453-4057qib7 3128 18 adult adult NN cord-005453-4057qib7 3128 19 and and CC cord-005453-4057qib7 3128 20 paediatric paediatric JJ cord-005453-4057qib7 3128 21 HSCT HSCT NNP cord-005453-4057qib7 3128 22 setting setting NN cord-005453-4057qib7 3128 23 . . . cord-005453-4057qib7 3129 1 Disclosure disclosure NN cord-005453-4057qib7 3129 2 Background background NN cord-005453-4057qib7 3129 3 : : : cord-005453-4057qib7 3130 1 The the DT cord-005453-4057qib7 3130 2 use use NN cord-005453-4057qib7 3130 3 of of IN cord-005453-4057qib7 3130 4 unmanipulated unmanipulated JJ cord-005453-4057qib7 3130 5 Haploidentical Haploidentical NNP cord-005453-4057qib7 3130 6 SCT SCT NNP cord-005453-4057qib7 3130 7 ( ( -LRB- cord-005453-4057qib7 3130 8 Haplo Haplo NNP cord-005453-4057qib7 3130 9 - - HYPH cord-005453-4057qib7 3130 10 SCT SCT NNP cord-005453-4057qib7 3130 11 ) ) -RRB- cord-005453-4057qib7 3130 12 with with IN cord-005453-4057qib7 3130 13 post post JJ cord-005453-4057qib7 3130 14 - - JJ cord-005453-4057qib7 3130 15 transplant transplant NN cord-005453-4057qib7 3130 16 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 3130 17 ( ( -LRB- cord-005453-4057qib7 3130 18 PT PT NNP cord-005453-4057qib7 3130 19 - - HYPH cord-005453-4057qib7 3130 20 Cy Cy NNP cord-005453-4057qib7 3130 21 ) ) -RRB- cord-005453-4057qib7 3130 22 as as IN cord-005453-4057qib7 3130 23 GVHD GVHD NNP cord-005453-4057qib7 3130 24 prophylaxis prophylaxis NN cord-005453-4057qib7 3130 25 has have VBZ cord-005453-4057qib7 3130 26 widely widely RB cord-005453-4057qib7 3130 27 extended extend VBN cord-005453-4057qib7 3130 28 . . . cord-005453-4057qib7 3131 1 Primary primary JJ cord-005453-4057qib7 3131 2 and and CC cord-005453-4057qib7 3131 3 secondary secondary JJ cord-005453-4057qib7 3131 4 graft graft NN cord-005453-4057qib7 3131 5 failure failure NN cord-005453-4057qib7 3131 6 are be VBP cord-005453-4057qib7 3131 7 relatively relatively RB cord-005453-4057qib7 3131 8 uncommon uncommon JJ cord-005453-4057qib7 3131 9 complications complication NNS cord-005453-4057qib7 3131 10 . . . cord-005453-4057qib7 3132 1 However however RB cord-005453-4057qib7 3132 2 , , , cord-005453-4057qib7 3132 3 poor poor JJ cord-005453-4057qib7 3132 4 graft graft NN cord-005453-4057qib7 3132 5 function function NN cord-005453-4057qib7 3132 6 ( ( -LRB- cord-005453-4057qib7 3132 7 PGF PGF NNP cord-005453-4057qib7 3132 8 ) ) -RRB- cord-005453-4057qib7 3132 9 after after IN cord-005453-4057qib7 3132 10 Haplo Haplo NNP cord-005453-4057qib7 3132 11 - - HYPH cord-005453-4057qib7 3132 12 SCT SCT NNP cord-005453-4057qib7 3132 13 with with IN cord-005453-4057qib7 3132 14 PT PT NNP cord-005453-4057qib7 3132 15 - - HYPH cord-005453-4057qib7 3132 16 Cy Cy NNP cord-005453-4057qib7 3132 17 has have VBZ cord-005453-4057qib7 3132 18 not not RB cord-005453-4057qib7 3132 19 been be VBN cord-005453-4057qib7 3132 20 described describe VBN cord-005453-4057qib7 3132 21 thoroughly thoroughly RB cord-005453-4057qib7 3132 22 . . . cord-005453-4057qib7 3133 1 The the DT cord-005453-4057qib7 3133 2 objective objective NN cord-005453-4057qib7 3133 3 of of IN cord-005453-4057qib7 3133 4 this this DT cord-005453-4057qib7 3133 5 study study NN cord-005453-4057qib7 3133 6 is be VBZ cord-005453-4057qib7 3133 7 to to TO cord-005453-4057qib7 3133 8 describe describe VB cord-005453-4057qib7 3133 9 characteristics characteristic NNS cord-005453-4057qib7 3133 10 , , , cord-005453-4057qib7 3133 11 treatments treatment NNS cord-005453-4057qib7 3133 12 and and CC cord-005453-4057qib7 3133 13 outcomes outcome NNS cord-005453-4057qib7 3133 14 of of IN cord-005453-4057qib7 3133 15 patients patient NNS cord-005453-4057qib7 3133 16 with with IN cord-005453-4057qib7 3133 17 PGF PGF NNP cord-005453-4057qib7 3133 18 after after IN cord-005453-4057qib7 3133 19 Haplo Haplo NNP cord-005453-4057qib7 3133 20 - - HYPH cord-005453-4057qib7 3133 21 SCT SCT NNP cord-005453-4057qib7 3133 22 with with IN cord-005453-4057qib7 3133 23 PT PT NNP cord-005453-4057qib7 3133 24 - - HYPH cord-005453-4057qib7 3133 25 Cy Cy NNP cord-005453-4057qib7 3133 26 . . . cord-005453-4057qib7 3134 1 Methods method NNS cord-005453-4057qib7 3134 2 : : : cord-005453-4057qib7 3134 3 We -PRON- PRP cord-005453-4057qib7 3134 4 retrospectively retrospectively RB cord-005453-4057qib7 3134 5 analyzed analyze VBD cord-005453-4057qib7 3134 6 132 132 CD cord-005453-4057qib7 3134 7 Haplo Haplo NNP cord-005453-4057qib7 3134 8 - - HYPH cord-005453-4057qib7 3134 9 SCT SCT NNP cord-005453-4057qib7 3134 10 with with IN cord-005453-4057qib7 3134 11 PT PT NNP cord-005453-4057qib7 3134 12 - - HYPH cord-005453-4057qib7 3134 13 Cy Cy NNP cord-005453-4057qib7 3134 14 consecutively consecutively RB cord-005453-4057qib7 3134 15 performed perform VBD cord-005453-4057qib7 3134 16 between between IN cord-005453-4057qib7 3134 17 2011 2011 CD cord-005453-4057qib7 3134 18 and and CC cord-005453-4057qib7 3134 19 2017 2017 CD cord-005453-4057qib7 3134 20 in in IN cord-005453-4057qib7 3134 21 our -PRON- PRP$ cord-005453-4057qib7 3134 22 centre centre NN cord-005453-4057qib7 3134 23 . . . cord-005453-4057qib7 3135 1 PGF PGF NNP cord-005453-4057qib7 3135 2 was be VBD cord-005453-4057qib7 3135 3 defined define VBN cord-005453-4057qib7 3135 4 as as IN cord-005453-4057qib7 3135 5 either either DT cord-005453-4057qib7 3135 6 occurring occur VBG cord-005453-4057qib7 3135 7 after after IN cord-005453-4057qib7 3135 8 initial initial JJ cord-005453-4057qib7 3135 9 engraftment engraftment NN cord-005453-4057qib7 3135 10 : : : cord-005453-4057qib7 3135 11 persistent persistent JJ cord-005453-4057qib7 3135 12 neutropenia neutropenia NN cord-005453-4057qib7 3135 13 ( ( -LRB- cord-005453-4057qib7 3135 14 ANC ANC NNP cord-005453-4057qib7 3135 15 < < XX cord-005453-4057qib7 3135 16 500 500 CD cord-005453-4057qib7 3135 17 / / SYM cord-005453-4057qib7 3135 18 uL uL NNP cord-005453-4057qib7 3135 19 ) ) -RRB- cord-005453-4057qib7 3135 20 with with IN cord-005453-4057qib7 3135 21 the the DT cord-005453-4057qib7 3135 22 need need NN cord-005453-4057qib7 3135 23 of of IN cord-005453-4057qib7 3135 24 at at RB cord-005453-4057qib7 3135 25 least least JJS cord-005453-4057qib7 3135 26 3 3 CD cord-005453-4057qib7 3135 27 doses dose NNS cord-005453-4057qib7 3135 28 of of IN cord-005453-4057qib7 3135 29 G G NNP cord-005453-4057qib7 3135 30 - - HYPH cord-005453-4057qib7 3135 31 CSF CSF NNP cord-005453-4057qib7 3135 32 and/or and/or CC cord-005453-4057qib7 3135 33 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 3136 1 ( ( -LRB- cord-005453-4057qib7 3136 2 platelets platelet NNS cord-005453-4057qib7 3137 1 < < NNP cord-005453-4057qib7 3137 2 20.000 20.000 CD cord-005453-4057qib7 3137 3 / / SYM cord-005453-4057qib7 3137 4 uL ul NN cord-005453-4057qib7 3137 5 ) ) -RRB- cord-005453-4057qib7 3138 1 with with IN cord-005453-4057qib7 3138 2 platelet platelet NN cord-005453-4057qib7 3138 3 transfusion transfusion NN cord-005453-4057qib7 3138 4 dependence dependence NN cord-005453-4057qib7 3138 5 , , , cord-005453-4057qib7 3138 6 with with IN cord-005453-4057qib7 3138 7 complete complete JJ cord-005453-4057qib7 3138 8 donor donor NN cord-005453-4057qib7 3138 9 chimerism chimerism NN cord-005453-4057qib7 3138 10 and and CC cord-005453-4057qib7 3138 11 without without IN cord-005453-4057qib7 3138 12 concurrent concurrent JJ cord-005453-4057qib7 3138 13 severe severe JJ cord-005453-4057qib7 3138 14 GVHD gvhd NN cord-005453-4057qib7 3138 15 or or CC cord-005453-4057qib7 3138 16 disease disease NN cord-005453-4057qib7 3138 17 relapse relapse NN cord-005453-4057qib7 3138 18 . . . cord-005453-4057qib7 3139 1 Results result NNS cord-005453-4057qib7 3139 2 : : : cord-005453-4057qib7 3140 1 Nineteen nineteen CD cord-005453-4057qib7 3140 2 patients patient NNS cord-005453-4057qib7 3140 3 were be VBD cord-005453-4057qib7 3140 4 excluded exclude VBN cord-005453-4057qib7 3140 5 from from IN cord-005453-4057qib7 3140 6 the the DT cord-005453-4057qib7 3140 7 analysis analysis NN cord-005453-4057qib7 3140 8 due due IN cord-005453-4057qib7 3140 9 to to IN cord-005453-4057qib7 3140 10 early early JJ cord-005453-4057qib7 3140 11 mortality mortality NN cord-005453-4057qib7 3140 12 ( ( -LRB- cord-005453-4057qib7 3140 13 death death NN cord-005453-4057qib7 3140 14 before before IN cord-005453-4057qib7 3140 15 day day NN cord-005453-4057qib7 3140 16 +30 +30 CD cord-005453-4057qib7 3140 17 ) ) -RRB- cord-005453-4057qib7 3140 18 , , , cord-005453-4057qib7 3140 19 primary primary JJ cord-005453-4057qib7 3140 20 graft graft NN cord-005453-4057qib7 3140 21 failure failure NN cord-005453-4057qib7 3140 22 ( ( -LRB- cord-005453-4057qib7 3140 23 absence absence NN cord-005453-4057qib7 3140 24 of of IN cord-005453-4057qib7 3140 25 neutrophil neutrophil NN cord-005453-4057qib7 3140 26 engraftment engraftment NN cord-005453-4057qib7 3140 27 by by IN cord-005453-4057qib7 3140 28 day day NN cord-005453-4057qib7 3140 29 +28 +28 NNP cord-005453-4057qib7 3140 30 , , , cord-005453-4057qib7 3140 31 with with IN cord-005453-4057qib7 3140 32 mixed mixed JJ cord-005453-4057qib7 3140 33 chimerism chimerism NN cord-005453-4057qib7 3140 34 ) ) -RRB- cord-005453-4057qib7 3140 35 or or CC cord-005453-4057qib7 3140 36 secondary secondary JJ cord-005453-4057qib7 3140 37 graft graft NN cord-005453-4057qib7 3140 38 failure failure NN cord-005453-4057qib7 3140 39 ( ( -LRB- cord-005453-4057qib7 3140 40 development development NN cord-005453-4057qib7 3140 41 of of IN cord-005453-4057qib7 3140 42 severe severe JJ cord-005453-4057qib7 3140 43 cytopenias cytopenia NNS cord-005453-4057qib7 3140 44 and and CC cord-005453-4057qib7 3140 45 mixed mixed JJ cord-005453-4057qib7 3140 46 chimerism chimerism NN cord-005453-4057qib7 3140 47 after after IN cord-005453-4057qib7 3140 48 initial initial JJ cord-005453-4057qib7 3140 49 achievement achievement NN cord-005453-4057qib7 3140 50 of of IN cord-005453-4057qib7 3140 51 neutrophil neutrophil NN cord-005453-4057qib7 3140 52 engraftment engraftment NN cord-005453-4057qib7 3140 53 ) ) -RRB- cord-005453-4057qib7 3140 54 . . . cord-005453-4057qib7 3141 1 Thirty thirty CD cord-005453-4057qib7 3141 2 one one CD cord-005453-4057qib7 3141 3 patients patient NNS cord-005453-4057qib7 3141 4 ( ( -LRB- cord-005453-4057qib7 3141 5 27,5 27,5 CD cord-005453-4057qib7 3141 6 % % NN cord-005453-4057qib7 3141 7 ) ) -RRB- cord-005453-4057qib7 3141 8 were be VBD cord-005453-4057qib7 3141 9 diagnosed diagnose VBN cord-005453-4057qib7 3141 10 with with IN cord-005453-4057qib7 3141 11 PGF PGF NNP cord-005453-4057qib7 3141 12 . . . cord-005453-4057qib7 3142 1 Main main JJ cord-005453-4057qib7 3142 2 characteristics characteristic NNS cord-005453-4057qib7 3142 3 of of IN cord-005453-4057qib7 3142 4 these these DT cord-005453-4057qib7 3142 5 patients patient NNS cord-005453-4057qib7 3142 6 are be VBP cord-005453-4057qib7 3142 7 summarized summarize VBN cord-005453-4057qib7 3142 8 in in IN cord-005453-4057qib7 3142 9 Table Table NNP cord-005453-4057qib7 3142 10 1 1 CD cord-005453-4057qib7 3142 11 . . . cord-005453-4057qib7 3143 1 Twenty twenty CD cord-005453-4057qib7 3143 2 six six CD cord-005453-4057qib7 3143 3 patients patient NNS cord-005453-4057qib7 3143 4 ( ( -LRB- cord-005453-4057qib7 3143 5 84 84 CD cord-005453-4057qib7 3143 6 % % NN cord-005453-4057qib7 3143 7 ) ) -RRB- cord-005453-4057qib7 3143 8 presented present VBN cord-005453-4057qib7 3143 9 with with IN cord-005453-4057qib7 3143 10 neutropenia neutropenia NN cord-005453-4057qib7 3143 11 and and CC cord-005453-4057qib7 3143 12 were be VBD cord-005453-4057qib7 3143 13 treated treat VBN cord-005453-4057qib7 3143 14 with with IN cord-005453-4057qib7 3143 15 G G NNP cord-005453-4057qib7 3143 16 - - HYPH cord-005453-4057qib7 3143 17 CSF CSF NNP cord-005453-4057qib7 3143 18 , , , cord-005453-4057qib7 3143 19 while while IN cord-005453-4057qib7 3143 20 5 5 CD cord-005453-4057qib7 3143 21 patients patient NNS cord-005453-4057qib7 3143 22 ( ( -LRB- cord-005453-4057qib7 3143 23 16 16 CD cord-005453-4057qib7 3143 24 % % NN cord-005453-4057qib7 3143 25 ) ) -RRB- cord-005453-4057qib7 3143 26 only only RB cord-005453-4057qib7 3143 27 developed develop VBD cord-005453-4057qib7 3143 28 severe severe JJ cord-005453-4057qib7 3143 29 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 3143 30 without without IN cord-005453-4057qib7 3143 31 neutropenia neutropenia NN cord-005453-4057qib7 3143 32 , , , cord-005453-4057qib7 3143 33 and and CC cord-005453-4057qib7 3143 34 were be VBD cord-005453-4057qib7 3143 35 treated treat VBN cord-005453-4057qib7 3143 36 only only RB cord-005453-4057qib7 3143 37 with with IN cord-005453-4057qib7 3143 38 platelet platelet NN cord-005453-4057qib7 3143 39 transfusion transfusion NN cord-005453-4057qib7 3143 40 . . . cord-005453-4057qib7 3144 1 Twenty twenty CD cord-005453-4057qib7 3144 2 four four CD cord-005453-4057qib7 3144 3 patients patient NNS cord-005453-4057qib7 3144 4 ( ( -LRB- cord-005453-4057qib7 3144 5 77,5 77,5 CD cord-005453-4057qib7 3144 6 % % NN cord-005453-4057qib7 3144 7 ) ) -RRB- cord-005453-4057qib7 3144 8 had have VBD cord-005453-4057qib7 3144 9 at at RB cord-005453-4057qib7 3144 10 least least JJS cord-005453-4057qib7 3144 11 1 1 CD cord-005453-4057qib7 3144 12 CMV CMV NNP cord-005453-4057qib7 3144 13 reactivation reactivation NN cord-005453-4057qib7 3144 14 , , , cord-005453-4057qib7 3144 15 15 15 CD cord-005453-4057qib7 3144 16 patients patient NNS cord-005453-4057qib7 3144 17 ( ( -LRB- cord-005453-4057qib7 3144 18 48 48 CD cord-005453-4057qib7 3144 19 % % NN cord-005453-4057qib7 3144 20 ) ) -RRB- cord-005453-4057qib7 3144 21 had have VBD cord-005453-4057qib7 3145 1 2 2 CD cord-005453-4057qib7 3145 2 or or CC cord-005453-4057qib7 3145 3 more more JJR cord-005453-4057qib7 3145 4 CMV CMV NNP cord-005453-4057qib7 3145 5 reactivations reactivation NNS cord-005453-4057qib7 3145 6 and and CC cord-005453-4057qib7 3145 7 21 21 CD cord-005453-4057qib7 3145 8 patients patient NNS cord-005453-4057qib7 3145 9 ( ( -LRB- cord-005453-4057qib7 3145 10 67 67 CD cord-005453-4057qib7 3145 11 % % NN cord-005453-4057qib7 3145 12 ) ) -RRB- cord-005453-4057qib7 3145 13 received receive VBD cord-005453-4057qib7 3145 14 valganciclovir valganciclovir NN cord-005453-4057qib7 3145 15 for for IN cord-005453-4057qib7 3145 16 CMV CMV NNP cord-005453-4057qib7 3145 17 reactivation reactivation NN cord-005453-4057qib7 3145 18 treatment treatment NN cord-005453-4057qib7 3145 19 . . . cord-005453-4057qib7 3146 1 Although although IN cord-005453-4057qib7 3146 2 most most JJS cord-005453-4057qib7 3146 3 patients patient NNS cord-005453-4057qib7 3146 4 achieved achieve VBD cord-005453-4057qib7 3146 5 adequate adequate JJ cord-005453-4057qib7 3146 6 peripheral peripheral JJ cord-005453-4057qib7 3146 7 blood blood NN cord-005453-4057qib7 3146 8 counts count NNS cord-005453-4057qib7 3146 9 ( ( -LRB- cord-005453-4057qib7 3146 10 PBC PBC NNP cord-005453-4057qib7 3146 11 ) ) -RRB- cord-005453-4057qib7 3146 12 with with IN cord-005453-4057qib7 3146 13 initial initial JJ cord-005453-4057qib7 3146 14 salvage salvage NN cord-005453-4057qib7 3146 15 therapy therapy NN cord-005453-4057qib7 3146 16 , , , cord-005453-4057qib7 3146 17 6 6 CD cord-005453-4057qib7 3146 18 patients patient NNS cord-005453-4057qib7 3146 19 ( ( -LRB- cord-005453-4057qib7 3146 20 19 19 CD cord-005453-4057qib7 3146 21 % % NN cord-005453-4057qib7 3146 22 ) ) -RRB- cord-005453-4057qib7 3146 23 had have VBD cord-005453-4057qib7 3146 24 persistent persistent JJ cord-005453-4057qib7 3146 25 cytopenias cytopenia NNS cord-005453-4057qib7 3146 26 in in IN cord-005453-4057qib7 3146 27 spite spite NN cord-005453-4057qib7 3146 28 of of IN cord-005453-4057qib7 3146 29 G G NNP cord-005453-4057qib7 3146 30 - - HYPH cord-005453-4057qib7 3146 31 CSF CSF NNP cord-005453-4057qib7 3146 32 , , , cord-005453-4057qib7 3146 33 platelet platelet NN cord-005453-4057qib7 3146 34 transfusion transfusion NN cord-005453-4057qib7 3146 35 , , , cord-005453-4057qib7 3146 36 CMV CMV NNP cord-005453-4057qib7 3146 37 reactivation reactivation NN cord-005453-4057qib7 3146 38 resolution resolution NN cord-005453-4057qib7 3146 39 and and CC cord-005453-4057qib7 3146 40 myelotoxic myelotoxic JJ cord-005453-4057qib7 3146 41 drugs drug NNS cord-005453-4057qib7 3146 42 withdrawal withdrawal NN cord-005453-4057qib7 3146 43 . . . cord-005453-4057qib7 3147 1 Four four CD cord-005453-4057qib7 3147 2 of of IN cord-005453-4057qib7 3147 3 them -PRON- PRP cord-005453-4057qib7 3147 4 were be VBD cord-005453-4057qib7 3147 5 treated treat VBN cord-005453-4057qib7 3147 6 with with IN cord-005453-4057qib7 3147 7 a a DT cord-005453-4057qib7 3147 8 boost boost NN cord-005453-4057qib7 3147 9 of of IN cord-005453-4057qib7 3147 10 CD34 CD34 NNP cord-005453-4057qib7 3147 11 + + SYM cord-005453-4057qib7 3147 12 selected select VBN cord-005453-4057qib7 3147 13 peripheral peripheral JJ cord-005453-4057qib7 3147 14 blood blood NN cord-005453-4057qib7 3147 15 donor donor NN cord-005453-4057qib7 3147 16 cells cell NNS cord-005453-4057qib7 3147 17 at at IN cord-005453-4057qib7 3147 18 a a DT cord-005453-4057qib7 3147 19 median median NN cord-005453-4057qib7 3147 20 of of IN cord-005453-4057qib7 3147 21 170 170 CD cord-005453-4057qib7 3147 22 days day NNS cord-005453-4057qib7 3147 23 after after RB cord-005453-4057qib7 3147 24 . . . cord-005453-4057qib7 3148 1 Median median JJ cord-005453-4057qib7 3148 2 CD34 CD34 NNP cord-005453-4057qib7 3149 1 + + CC cord-005453-4057qib7 3149 2 cells cell NNS cord-005453-4057qib7 3149 3 infused infuse VBN cord-005453-4057qib7 3149 4 was be VBD cord-005453-4057qib7 3149 5 3,42 3,42 CD cord-005453-4057qib7 3149 6 x10 x10 CD cord-005453-4057qib7 3149 7 6 6 CD cord-005453-4057qib7 3150 1 /kg /kg NFP cord-005453-4057qib7 3150 2 . . . cord-005453-4057qib7 3151 1 These these DT cord-005453-4057qib7 3151 2 4 4 CD cord-005453-4057qib7 3151 3 patients patient NNS cord-005453-4057qib7 3151 4 achieved achieve VBD cord-005453-4057qib7 3151 5 adequate adequate JJ cord-005453-4057qib7 3151 6 PBC PBC NNP cord-005453-4057qib7 3151 7 after after IN cord-005453-4057qib7 3151 8 salvage salvage NN cord-005453-4057qib7 3151 9 therapy therapy NN cord-005453-4057qib7 3151 10 and and CC cord-005453-4057qib7 3151 11 two two CD cord-005453-4057qib7 3151 12 developed develop VBN cord-005453-4057qib7 3151 13 GVHD GVHD NNP cord-005453-4057qib7 3151 14 . . . cord-005453-4057qib7 3152 1 The the DT cord-005453-4057qib7 3152 2 other other JJ cord-005453-4057qib7 3152 3 2 2 CD cord-005453-4057qib7 3152 4 patients patient NNS cord-005453-4057qib7 3152 5 were be VBD cord-005453-4057qib7 3152 6 treated treat VBN cord-005453-4057qib7 3152 7 with with IN cord-005453-4057qib7 3152 8 increasing increase VBG cord-005453-4057qib7 3152 9 doses dose NNS cord-005453-4057qib7 3152 10 of of IN cord-005453-4057qib7 3152 11 thrombopoietin thrombopoietin NNP cord-005453-4057qib7 3152 12 ( ( -LRB- cord-005453-4057qib7 3152 13 TPO TPO NNP cord-005453-4057qib7 3152 14 ) ) -RRB- cord-005453-4057qib7 3152 15 receptor receptor NN cord-005453-4057qib7 3152 16 agonist agonist NN cord-005453-4057qib7 3152 17 ( ( -LRB- cord-005453-4057qib7 3152 18 TRA TRA NNP cord-005453-4057qib7 3152 19 ) ) -RRB- cord-005453-4057qib7 3152 20 eltrombopag eltrombopag NNP cord-005453-4057qib7 3152 21 . . . cord-005453-4057qib7 3153 1 One one CD cord-005453-4057qib7 3153 2 patient patient NN cord-005453-4057qib7 3153 3 started start VBD cord-005453-4057qib7 3153 4 treatment treatment NN cord-005453-4057qib7 3153 5 160 160 CD cord-005453-4057qib7 3153 6 days day NNS cord-005453-4057qib7 3153 7 after after IN cord-005453-4057qib7 3153 8 HSCT HSCT NNP cord-005453-4057qib7 3153 9 with with IN cord-005453-4057qib7 3153 10 25 25 CD cord-005453-4057qib7 3153 11 mg mg NNP cord-005453-4057qib7 3153 12 daily daily RB cord-005453-4057qib7 3153 13 and and CC cord-005453-4057qib7 3153 14 increased increase VBD cord-005453-4057qib7 3153 15 dose dose NN cord-005453-4057qib7 3153 16 to to IN cord-005453-4057qib7 3153 17 125 125 CD cord-005453-4057qib7 3153 18 mg mg NNP cord-005453-4057qib7 3153 19 daily daily RB cord-005453-4057qib7 3153 20 , , , cord-005453-4057qib7 3153 21 with with IN cord-005453-4057qib7 3153 22 complete complete JJ cord-005453-4057qib7 3153 23 recovery recovery NN cord-005453-4057qib7 3153 24 of of IN cord-005453-4057qib7 3153 25 PBC PBC NNP cord-005453-4057qib7 3153 26 6 6 CD cord-005453-4057qib7 3153 27 months month NNS cord-005453-4057qib7 3153 28 after after IN cord-005453-4057qib7 3153 29 initiating initiate VBG cord-005453-4057qib7 3153 30 TRA TRA NNP cord-005453-4057qib7 3153 31 . . . cord-005453-4057qib7 3154 1 The the DT cord-005453-4057qib7 3154 2 second second JJ cord-005453-4057qib7 3154 3 patient patient NN cord-005453-4057qib7 3154 4 started start VBD cord-005453-4057qib7 3154 5 treatment treatment NN cord-005453-4057qib7 3154 6 110 110 CD cord-005453-4057qib7 3154 7 days day NNS cord-005453-4057qib7 3154 8 after after IN cord-005453-4057qib7 3154 9 HSCT HSCT NNP cord-005453-4057qib7 3154 10 with with IN cord-005453-4057qib7 3154 11 25 25 CD cord-005453-4057qib7 3154 12 mg mg NNP cord-005453-4057qib7 3154 13 daily daily RB cord-005453-4057qib7 3154 14 and and CC cord-005453-4057qib7 3154 15 increased increase VBD cord-005453-4057qib7 3154 16 dose dose NN cord-005453-4057qib7 3154 17 to to IN cord-005453-4057qib7 3154 18 100 100 CD cord-005453-4057qib7 3154 19 mg mg NNP cord-005453-4057qib7 3154 20 daily daily RB cord-005453-4057qib7 3154 21 , , , cord-005453-4057qib7 3154 22 with with IN cord-005453-4057qib7 3154 23 complete complete JJ cord-005453-4057qib7 3154 24 recovery recovery NN cord-005453-4057qib7 3154 25 of of IN cord-005453-4057qib7 3154 26 PBC PBC NNP cord-005453-4057qib7 3154 27 2 2 CD cord-005453-4057qib7 3154 28 months month NNS cord-005453-4057qib7 3154 29 after after IN cord-005453-4057qib7 3154 30 initiating initiate VBG cord-005453-4057qib7 3154 31 TRA TRA NNP cord-005453-4057qib7 3154 32 . . . cord-005453-4057qib7 3155 1 Twenty twenty CD cord-005453-4057qib7 3155 2 one one CD cord-005453-4057qib7 3155 3 patients patient NNS cord-005453-4057qib7 3155 4 ( ( -LRB- cord-005453-4057qib7 3155 5 67 67 CD cord-005453-4057qib7 3155 6 % % NN cord-005453-4057qib7 3155 7 ) ) -RRB- cord-005453-4057qib7 3155 8 with with IN cord-005453-4057qib7 3155 9 PGF PGF NNP cord-005453-4057qib7 3155 10 diagnosis diagnosis NN cord-005453-4057qib7 3155 11 had have VBD cord-005453-4057qib7 3155 12 long long JJ cord-005453-4057qib7 3155 13 term term NN cord-005453-4057qib7 3155 14 survival survival NN cord-005453-4057qib7 3155 15 . . . cord-005453-4057qib7 3156 1 Conclusions conclusion NNS cord-005453-4057qib7 3156 2 : : : cord-005453-4057qib7 3157 1 Poor poor JJ cord-005453-4057qib7 3157 2 graft graft NN cord-005453-4057qib7 3157 3 function function NN cord-005453-4057qib7 3157 4 is be VBZ cord-005453-4057qib7 3157 5 a a DT cord-005453-4057qib7 3157 6 frequent frequent JJ cord-005453-4057qib7 3157 7 complication complication NN cord-005453-4057qib7 3157 8 after after IN cord-005453-4057qib7 3157 9 Haplo Haplo NNP cord-005453-4057qib7 3157 10 - - HYPH cord-005453-4057qib7 3157 11 SCT SCT NNP cord-005453-4057qib7 3157 12 with with IN cord-005453-4057qib7 3157 13 Cy Cy NNP cord-005453-4057qib7 3157 14 - - HYPH cord-005453-4057qib7 3157 15 post post NNP cord-005453-4057qib7 3157 16 . . . cord-005453-4057qib7 3158 1 CMV CMV NNP cord-005453-4057qib7 3158 2 reactivation reactivation NN cord-005453-4057qib7 3158 3 and and CC cord-005453-4057qib7 3158 4 myelotoxic myelotoxic JJ cord-005453-4057qib7 3158 5 drugs drug NNS cord-005453-4057qib7 3158 6 could could MD cord-005453-4057qib7 3158 7 be be VB cord-005453-4057qib7 3158 8 the the DT cord-005453-4057qib7 3158 9 most most RBS cord-005453-4057qib7 3158 10 relevant relevant JJ cord-005453-4057qib7 3158 11 factors factor NNS cord-005453-4057qib7 3158 12 associated associate VBN cord-005453-4057qib7 3158 13 with with IN cord-005453-4057qib7 3158 14 development development NN cord-005453-4057qib7 3158 15 of of IN cord-005453-4057qib7 3158 16 this this DT cord-005453-4057qib7 3158 17 entity entity NN cord-005453-4057qib7 3158 18 . . . cord-005453-4057qib7 3159 1 Although although IN cord-005453-4057qib7 3159 2 most most JJS cord-005453-4057qib7 3159 3 patients patient NNS cord-005453-4057qib7 3159 4 recover recover VBP cord-005453-4057qib7 3159 5 PBC PBC NNP cord-005453-4057qib7 3159 6 without without IN cord-005453-4057qib7 3159 7 specific specific JJ cord-005453-4057qib7 3159 8 therapies therapy NNS cord-005453-4057qib7 3159 9 beyond beyond IN cord-005453-4057qib7 3159 10 G G NNP cord-005453-4057qib7 3159 11 - - HYPH cord-005453-4057qib7 3159 12 CSF csf NN cord-005453-4057qib7 3159 13 and and CC cord-005453-4057qib7 3159 14 platelets platelet NNS cord-005453-4057qib7 3159 15 transfusion transfusion NN cord-005453-4057qib7 3159 16 , , , cord-005453-4057qib7 3159 17 there there EX cord-005453-4057qib7 3159 18 is be VBZ cord-005453-4057qib7 3159 19 a a DT cord-005453-4057qib7 3159 20 small small JJ cord-005453-4057qib7 3159 21 group group NN cord-005453-4057qib7 3159 22 of of IN cord-005453-4057qib7 3159 23 patients patient NNS cord-005453-4057qib7 3159 24 with with IN cord-005453-4057qib7 3159 25 persistent persistent JJ cord-005453-4057qib7 3159 26 cytopenias cytopenia NNS cord-005453-4057qib7 3159 27 . . . cord-005453-4057qib7 3160 1 Boost boost NN cord-005453-4057qib7 3160 2 of of IN cord-005453-4057qib7 3160 3 CD34 CD34 NNP cord-005453-4057qib7 3160 4 + + SYM cord-005453-4057qib7 3160 5 selected select VBN cord-005453-4057qib7 3160 6 cells cell NNS cord-005453-4057qib7 3160 7 is be VBZ cord-005453-4057qib7 3160 8 effective effective JJ cord-005453-4057qib7 3160 9 in in IN cord-005453-4057qib7 3160 10 reverting revert VBG cord-005453-4057qib7 3160 11 this this DT cord-005453-4057qib7 3160 12 condition condition NN cord-005453-4057qib7 3160 13 , , , cord-005453-4057qib7 3160 14 with with IN cord-005453-4057qib7 3160 15 GVHD GVHD NNP cord-005453-4057qib7 3160 16 as as IN cord-005453-4057qib7 3160 17 main main JJ cord-005453-4057qib7 3160 18 complication complication NN cord-005453-4057qib7 3160 19 of of IN cord-005453-4057qib7 3160 20 this this DT cord-005453-4057qib7 3160 21 procedure procedure NN cord-005453-4057qib7 3160 22 . . . cord-005453-4057qib7 3161 1 Use Use NNP cord-005453-4057qib7 3161 2 of of IN cord-005453-4057qib7 3161 3 TRA TRA NNP cord-005453-4057qib7 3161 4 seems seem VBZ cord-005453-4057qib7 3161 5 to to TO cord-005453-4057qib7 3161 6 be be VB cord-005453-4057qib7 3161 7 an an DT cord-005453-4057qib7 3161 8 interesting interesting JJ cord-005453-4057qib7 3161 9 option option NN cord-005453-4057qib7 3161 10 for for IN cord-005453-4057qib7 3161 11 these these DT cord-005453-4057qib7 3161 12 patients patient NNS cord-005453-4057qib7 3161 13 , , , cord-005453-4057qib7 3161 14 although although IN cord-005453-4057qib7 3161 15 more more JJR cord-005453-4057qib7 3161 16 experience experience NN cord-005453-4057qib7 3161 17 is be VBZ cord-005453-4057qib7 3161 18 needed need VBN cord-005453-4057qib7 3161 19 to to TO cord-005453-4057qib7 3161 20 draw draw VB cord-005453-4057qib7 3161 21 definitive definitive JJ cord-005453-4057qib7 3161 22 conclusions conclusion NNS cord-005453-4057qib7 3161 23 . . . cord-005453-4057qib7 3162 1 Disclosure disclosure NN cord-005453-4057qib7 3162 2 : : : cord-005453-4057qib7 3162 3 Nothing nothing NN cord-005453-4057qib7 3162 4 to to TO cord-005453-4057qib7 3162 5 declare declare VB cord-005453-4057qib7 3162 6 . . . cord-005453-4057qib7 3163 1 were be VBD cord-005453-4057qib7 3163 2 also also RB cord-005453-4057qib7 3163 3 frequently frequently RB cord-005453-4057qib7 3163 4 observed observe VBN cord-005453-4057qib7 3163 5 . . . cord-005453-4057qib7 3164 1 The the DT cord-005453-4057qib7 3164 2 high high JJ cord-005453-4057qib7 3164 3 risk risk NN cord-005453-4057qib7 3164 4 patients patient NNS cord-005453-4057qib7 3164 5 for for IN cord-005453-4057qib7 3164 6 anxiety anxiety NN cord-005453-4057qib7 3164 7 ( ( -LRB- cord-005453-4057qib7 3164 8 HADS HADS NNP cord-005453-4057qib7 3164 9 - - HYPH cord-005453-4057qib7 3164 10 A a DT cord-005453-4057qib7 3164 11 score score NN cord-005453-4057qib7 3164 12 ≥ ≥ CD cord-005453-4057qib7 3164 13 8) 8) NN cord-005453-4057qib7 3164 14 and and CC cord-005453-4057qib7 3164 15 depression depression NN cord-005453-4057qib7 3164 16 ( ( -LRB- cord-005453-4057qib7 3164 17 HADS HADS NNP cord-005453-4057qib7 3164 18 - - HYPH cord-005453-4057qib7 3164 19 D d JJ cord-005453-4057qib7 3164 20 score score NN cord-005453-4057qib7 3164 21 ≥ ≥ CD cord-005453-4057qib7 3164 22 8) 8) NN cord-005453-4057qib7 3164 23 was be VBD cord-005453-4057qib7 3164 24 found find VBN cord-005453-4057qib7 3164 25 in in IN cord-005453-4057qib7 3164 26 14.9 14.9 CD cord-005453-4057qib7 3164 27 % % NN cord-005453-4057qib7 3164 28 and and CC cord-005453-4057qib7 3164 29 13.6 13.6 CD cord-005453-4057qib7 3164 30 % % NN cord-005453-4057qib7 3164 31 , , , cord-005453-4057qib7 3164 32 respectively respectively RB cord-005453-4057qib7 3164 33 . . . cord-005453-4057qib7 3165 1 10.4 10.4 CD cord-005453-4057qib7 3165 2 % % NN cord-005453-4057qib7 3165 3 of of IN cord-005453-4057qib7 3165 4 patients patient NNS cord-005453-4057qib7 3165 5 was be VBD cord-005453-4057qib7 3165 6 in in IN cord-005453-4057qib7 3165 7 high high JJ cord-005453-4057qib7 3165 8 distress distress NN cord-005453-4057qib7 3165 9 status status NN cord-005453-4057qib7 3165 10 ( ( -LRB- cord-005453-4057qib7 3165 11 NCCN NCCN NNP cord-005453-4057qib7 3165 12 DT DT NNP cord-005453-4057qib7 3165 13 score score NN cord-005453-4057qib7 3165 14 ≥ ≥ CD cord-005453-4057qib7 3165 15 4 4 CD cord-005453-4057qib7 3165 16 ) ) -RRB- cord-005453-4057qib7 3165 17 . . . cord-005453-4057qib7 3166 1 We -PRON- PRP cord-005453-4057qib7 3166 2 found find VBD cord-005453-4057qib7 3166 3 that that IN cord-005453-4057qib7 3166 4 younger young JJR cord-005453-4057qib7 3166 5 age age NN cord-005453-4057qib7 3166 6 ( ( -LRB- cord-005453-4057qib7 3166 7 < < XX cord-005453-4057qib7 3166 8 60 60 CD cord-005453-4057qib7 3166 9 years year NNS cord-005453-4057qib7 3166 10 ) ) -RRB- cord-005453-4057qib7 3166 11 was be VBD cord-005453-4057qib7 3166 12 significantly significantly RB cord-005453-4057qib7 3166 13 associated associate VBN cord-005453-4057qib7 3166 14 with with IN cord-005453-4057qib7 3166 15 poor poor JJ cord-005453-4057qib7 3166 16 quality quality NN cord-005453-4057qib7 3166 17 of of IN cord-005453-4057qib7 3166 18 life life NN cord-005453-4057qib7 3166 19 score score NN cord-005453-4057qib7 3166 20 ( ( -LRB- cord-005453-4057qib7 3166 21 FACT fact NN cord-005453-4057qib7 3166 22 - - HYPH cord-005453-4057qib7 3166 23 BMT BMT NNP cord-005453-4057qib7 3166 24 ) ) -RRB- cord-005453-4057qib7 3167 1 ( ( -LRB- cord-005453-4057qib7 3167 2 P=0.001 P=0.001 NNP cord-005453-4057qib7 3167 3 ) ) -RRB- cord-005453-4057qib7 3167 4 and and CC cord-005453-4057qib7 3167 5 high high JJ cord-005453-4057qib7 3167 6 risk risk NN cord-005453-4057qib7 3167 7 of of IN cord-005453-4057qib7 3167 8 fatigue fatigue NN cord-005453-4057qib7 3167 9 ( ( -LRB- cord-005453-4057qib7 3167 10 P=0.008 P=0.008 NNP cord-005453-4057qib7 3167 11 ) ) -RRB- cord-005453-4057qib7 3167 12 , , , cord-005453-4057qib7 3167 13 anxiety anxiety NN cord-005453-4057qib7 3167 14 ( ( -LRB- cord-005453-4057qib7 3167 15 HADS HADS NNP cord-005453-4057qib7 3167 16 - - HYPH cord-005453-4057qib7 3167 17 A A NNP cord-005453-4057qib7 3167 18 ) ) -RRB- cord-005453-4057qib7 3167 19 ( ( -LRB- cord-005453-4057qib7 3167 20 P=0.001 P=0.001 NNP cord-005453-4057qib7 3167 21 ) ) -RRB- cord-005453-4057qib7 3167 22 , , , cord-005453-4057qib7 3167 23 and and CC cord-005453-4057qib7 3167 24 depression depression NN cord-005453-4057qib7 3167 25 ( ( -LRB- cord-005453-4057qib7 3167 26 HADS HADS NNP cord-005453-4057qib7 3167 27 - - HYPH cord-005453-4057qib7 3167 28 D D NNP cord-005453-4057qib7 3167 29 ) ) -RRB- cord-005453-4057qib7 3167 30 ( ( -LRB- cord-005453-4057qib7 3167 31 P=0.025 P=0.025 NNP cord-005453-4057qib7 3167 32 ) ) -RRB- cord-005453-4057qib7 3167 33 . . . cord-005453-4057qib7 3168 1 Female female JJ cord-005453-4057qib7 3168 2 sex sex NN cord-005453-4057qib7 3168 3 was be VBD cord-005453-4057qib7 3168 4 significantly significantly RB cord-005453-4057qib7 3168 5 related relate VBN cord-005453-4057qib7 3168 6 to to IN cord-005453-4057qib7 3168 7 lower low JJR cord-005453-4057qib7 3168 8 physical physical JJ cord-005453-4057qib7 3168 9 well well RB cord-005453-4057qib7 3168 10 - - HYPH cord-005453-4057qib7 3168 11 being be VBG cord-005453-4057qib7 3168 12 score score NN cord-005453-4057qib7 3168 13 and and CC cord-005453-4057qib7 3168 14 higher high JJR cord-005453-4057qib7 3168 15 distress distress NN cord-005453-4057qib7 3168 16 score score NN cord-005453-4057qib7 3168 17 ( ( -LRB- cord-005453-4057qib7 3168 18 P= p= NN cord-005453-4057qib7 3168 19 0.046 0.046 CD cord-005453-4057qib7 3168 20 and and CC cord-005453-4057qib7 3168 21 P=0.05 P=0.05 NNS cord-005453-4057qib7 3168 22 , , , cord-005453-4057qib7 3168 23 respectively respectively RB cord-005453-4057qib7 3168 24 ) ) -RRB- cord-005453-4057qib7 3168 25 . . . cord-005453-4057qib7 3169 1 Acute acute JJ cord-005453-4057qib7 3169 2 lymphoblast lymphoblast NN cord-005453-4057qib7 3169 3 leukemia leukemia NN cord-005453-4057qib7 3169 4 ( ( -LRB- cord-005453-4057qib7 3169 5 ALL all DT cord-005453-4057qib7 3169 6 ) ) -RRB- cord-005453-4057qib7 3169 7 survivors survivor NNS cord-005453-4057qib7 3169 8 after after IN cord-005453-4057qib7 3169 9 allo allo NN cord-005453-4057qib7 3169 10 - - HYPH cord-005453-4057qib7 3169 11 HCT HCT NNP cord-005453-4057qib7 3169 12 showed show VBD cord-005453-4057qib7 3169 13 significantly significantly RB cord-005453-4057qib7 3169 14 worse bad JJR cord-005453-4057qib7 3169 15 quality quality NN cord-005453-4057qib7 3169 16 of of IN cord-005453-4057qib7 3169 17 life life NN cord-005453-4057qib7 3169 18 score score NN cord-005453-4057qib7 3169 19 ( ( -LRB- cord-005453-4057qib7 3169 20 FACT fact NN cord-005453-4057qib7 3169 21 - - HYPH cord-005453-4057qib7 3169 22 BMT BMT NNP cord-005453-4057qib7 3169 23 ) ) -RRB- cord-005453-4057qib7 3170 1 ( ( -LRB- cord-005453-4057qib7 3170 2 P=0.006 P=0.006 NNP cord-005453-4057qib7 3170 3 ) ) -RRB- cord-005453-4057qib7 3170 4 and and CC cord-005453-4057qib7 3170 5 higher high JJR cord-005453-4057qib7 3170 6 depression depression NN cord-005453-4057qib7 3170 7 score score NN cord-005453-4057qib7 3170 8 ( ( -LRB- cord-005453-4057qib7 3170 9 HADS HADS NNP cord-005453-4057qib7 3170 10 - - HYPH cord-005453-4057qib7 3170 11 D D NNP cord-005453-4057qib7 3170 12 ) ) -RRB- cord-005453-4057qib7 3170 13 ( ( -LRB- cord-005453-4057qib7 3170 14 P=0.028 p=0.028 NN cord-005453-4057qib7 3170 15 ) ) -RRB- cord-005453-4057qib7 3170 16 compared compare VBN cord-005453-4057qib7 3170 17 to to IN cord-005453-4057qib7 3170 18 those those DT cord-005453-4057qib7 3170 19 with with IN cord-005453-4057qib7 3170 20 other other JJ cord-005453-4057qib7 3170 21 disease disease NN cord-005453-4057qib7 3170 22 . . . cord-005453-4057qib7 3171 1 Chronic chronic JJ cord-005453-4057qib7 3171 2 graft graft NN cord-005453-4057qib7 3171 3 versus versus IN cord-005453-4057qib7 3171 4 host host NN cord-005453-4057qib7 3171 5 disease disease NN cord-005453-4057qib7 3171 6 ( ( -LRB- cord-005453-4057qib7 3171 7 GVHD GVHD NNP cord-005453-4057qib7 3171 8 ) ) -RRB- cord-005453-4057qib7 3171 9 and and CC cord-005453-4057qib7 3171 10 continuous continuous JJ cord-005453-4057qib7 3171 11 immunosuppressant immunosuppressant JJ cord-005453-4057qib7 3171 12 usage usage NN cord-005453-4057qib7 3171 13 also also RB cord-005453-4057qib7 3171 14 have have VBP cord-005453-4057qib7 3171 15 significant significant JJ cord-005453-4057qib7 3171 16 adverse adverse JJ cord-005453-4057qib7 3171 17 impact impact NN cord-005453-4057qib7 3171 18 on on IN cord-005453-4057qib7 3171 19 lower low JJR cord-005453-4057qib7 3171 20 FACT fact NN cord-005453-4057qib7 3171 21 - - HYPH cord-005453-4057qib7 3171 22 BMT BMT NNP cord-005453-4057qib7 3171 23 score score NN cord-005453-4057qib7 3171 24 ( ( -LRB- cord-005453-4057qib7 3171 25 P=0.024 P=0.024 NNP cord-005453-4057qib7 3171 26 and and CC cord-005453-4057qib7 3171 27 P=0.033 P=0.033 NNP cord-005453-4057qib7 3171 28 , , , cord-005453-4057qib7 3171 29 respectively respectively RB cord-005453-4057qib7 3171 30 ) ) -RRB- cord-005453-4057qib7 3171 31 and and CC cord-005453-4057qib7 3171 32 higher high JJR cord-005453-4057qib7 3171 33 HADS HADS NNP cord-005453-4057qib7 3171 34 - - HYPH cord-005453-4057qib7 3171 35 D d JJ cord-005453-4057qib7 3171 36 score score NN cord-005453-4057qib7 3171 37 ( ( -LRB- cord-005453-4057qib7 3171 38 P=0.015 P=0.015 NNP cord-005453-4057qib7 3171 39 and and CC cord-005453-4057qib7 3171 40 P=0.019 P=0.019 NNP cord-005453-4057qib7 3171 41 , , , cord-005453-4057qib7 3171 42 respectively respectively RB cord-005453-4057qib7 3171 43 ) ) -RRB- cord-005453-4057qib7 3171 44 . . . cord-005453-4057qib7 3172 1 But but CC cord-005453-4057qib7 3172 2 there there EX cord-005453-4057qib7 3172 3 was be VBD cord-005453-4057qib7 3172 4 no no DT cord-005453-4057qib7 3172 5 significant significant JJ cord-005453-4057qib7 3172 6 difference difference NN cord-005453-4057qib7 3172 7 in in IN cord-005453-4057qib7 3172 8 FACT fact NN cord-005453-4057qib7 3173 1 BMT BMT NNP cord-005453-4057qib7 3173 2 , , , cord-005453-4057qib7 3173 3 HADS HADS NNP cord-005453-4057qib7 3173 4 - - HYPH cord-005453-4057qib7 3173 5 A A NNP cord-005453-4057qib7 3173 6 , , , cord-005453-4057qib7 3173 7 HADS HADS NNP cord-005453-4057qib7 3173 8 - - HYPH cord-005453-4057qib7 3173 9 D D NNP cord-005453-4057qib7 3173 10 , , , cord-005453-4057qib7 3173 11 NCCN NCCN NNP cord-005453-4057qib7 3173 12 DT DT NNP cord-005453-4057qib7 3173 13 according accord VBG cord-005453-4057qib7 3173 14 to to IN cord-005453-4057qib7 3173 15 donor donor NN cord-005453-4057qib7 3173 16 type type NN cord-005453-4057qib7 3173 17 , , , cord-005453-4057qib7 3173 18 conditioning conditioning NN cord-005453-4057qib7 3173 19 intensity intensity NN cord-005453-4057qib7 3173 20 , , , cord-005453-4057qib7 3173 21 anti anti JJ cord-005453-4057qib7 3173 22 - - JJ cord-005453-4057qib7 3173 23 thymocyte thymocyte JJ cord-005453-4057qib7 3173 24 globulin globulin NN cord-005453-4057qib7 3173 25 use use NN cord-005453-4057qib7 3173 26 , , , cord-005453-4057qib7 3173 27 acute acute JJ cord-005453-4057qib7 3173 28 GVHD GVHD NNP cord-005453-4057qib7 3173 29 . . . cord-005453-4057qib7 3174 1 Smoking smoking NN cord-005453-4057qib7 3174 2 and and CC cord-005453-4057qib7 3174 3 alcohol alcohol NN cord-005453-4057qib7 3174 4 drinking drinking NN cord-005453-4057qib7 3174 5 was be VBD cord-005453-4057qib7 3174 6 continued continue VBN cord-005453-4057qib7 3174 7 in in IN cord-005453-4057qib7 3174 8 7.5 7.5 CD cord-005453-4057qib7 3174 9 % % NN cord-005453-4057qib7 3174 10 and and CC cord-005453-4057qib7 3174 11 17.9 17.9 CD cord-005453-4057qib7 3174 12 % % NN cord-005453-4057qib7 3174 13 of of IN cord-005453-4057qib7 3174 14 allo allo NN cord-005453-4057qib7 3174 15 - - HYPH cord-005453-4057qib7 3174 16 HCT hct NN cord-005453-4057qib7 3174 17 survivors survivor NNS cord-005453-4057qib7 3174 18 . . . cord-005453-4057qib7 3175 1 20.9 20.9 CD cord-005453-4057qib7 3175 2 % % NN cord-005453-4057qib7 3175 3 of of IN cord-005453-4057qib7 3175 4 survivors survivor NNS cord-005453-4057qib7 3175 5 did do VBD cord-005453-4057qib7 3175 6 not not RB cord-005453-4057qib7 3175 7 exercise exercise VB cord-005453-4057qib7 3175 8 regularly regularly RB cord-005453-4057qib7 3175 9 . . . cord-005453-4057qib7 3176 1 Regular regular JJ cord-005453-4057qib7 3176 2 health health NN cord-005453-4057qib7 3176 3 screening screening NN cord-005453-4057qib7 3176 4 tests test NNS cord-005453-4057qib7 3176 5 have have VBP cord-005453-4057qib7 3176 6 been be VBN cord-005453-4057qib7 3176 7 done do VBN cord-005453-4057qib7 3176 8 only only RB cord-005453-4057qib7 3176 9 in in IN cord-005453-4057qib7 3176 10 40 40 CD cord-005453-4057qib7 3176 11 patients patient NNS cord-005453-4057qib7 3176 12 ( ( -LRB- cord-005453-4057qib7 3176 13 59.7 59.7 CD cord-005453-4057qib7 3176 14 % % NN cord-005453-4057qib7 3176 15 ) ) -RRB- cord-005453-4057qib7 3176 16 . . . cord-005453-4057qib7 3177 1 Conclusions conclusion NNS cord-005453-4057qib7 3177 2 : : : cord-005453-4057qib7 3178 1 Allo Allo NNP cord-005453-4057qib7 3178 2 - - HYPH cord-005453-4057qib7 3178 3 HCT hct NN cord-005453-4057qib7 3178 4 survivors survivor NNS cord-005453-4057qib7 3178 5 over over IN cord-005453-4057qib7 3178 6 2 2 CD cord-005453-4057qib7 3178 7 years year NNS cord-005453-4057qib7 3178 8 following follow VBG cord-005453-4057qib7 3178 9 allo allo NN cord-005453-4057qib7 3178 10 - - HYPH cord-005453-4057qib7 3178 11 HCT hct NN cord-005453-4057qib7 3178 12 still still RB cord-005453-4057qib7 3178 13 have have VBP cord-005453-4057qib7 3178 14 many many JJ cord-005453-4057qib7 3178 15 physical physical JJ cord-005453-4057qib7 3178 16 and and CC cord-005453-4057qib7 3178 17 psychological psychological JJ cord-005453-4057qib7 3178 18 symptoms symptom NNS cord-005453-4057qib7 3178 19 . . . cord-005453-4057qib7 3179 1 Younger young JJR cord-005453-4057qib7 3179 2 patients patient NNS cord-005453-4057qib7 3179 3 ( ( -LRB- cord-005453-4057qib7 3179 4 < < XX cord-005453-4057qib7 3179 5 60 60 CD cord-005453-4057qib7 3179 6 years year NNS cord-005453-4057qib7 3179 7 ) ) -RRB- cord-005453-4057qib7 3179 8 , , , cord-005453-4057qib7 3179 9 female female JJ cord-005453-4057qib7 3179 10 , , , cord-005453-4057qib7 3179 11 ALL all DT cord-005453-4057qib7 3179 12 , , , cord-005453-4057qib7 3179 13 chronic chronic JJ cord-005453-4057qib7 3179 14 GVHD GVHD NNP cord-005453-4057qib7 3179 15 , , , cord-005453-4057qib7 3179 16 and and CC cord-005453-4057qib7 3179 17 sustained sustain VBN cord-005453-4057qib7 3179 18 use use NN cord-005453-4057qib7 3179 19 of of IN cord-005453-4057qib7 3179 20 immunosuppressant immunosuppressant JJ cord-005453-4057qib7 3179 21 were be VBD cord-005453-4057qib7 3179 22 significant significant JJ cord-005453-4057qib7 3179 23 risk risk NN cord-005453-4057qib7 3179 24 factors factor NNS cord-005453-4057qib7 3179 25 for for IN cord-005453-4057qib7 3179 26 poor poor JJ cord-005453-4057qib7 3179 27 quality quality NN cord-005453-4057qib7 3179 28 of of IN cord-005453-4057qib7 3179 29 life life NN cord-005453-4057qib7 3179 30 and and CC cord-005453-4057qib7 3179 31 anxiety anxiety NN cord-005453-4057qib7 3179 32 . . . cord-005453-4057qib7 3180 1 We -PRON- PRP cord-005453-4057qib7 3180 2 need need VBP cord-005453-4057qib7 3180 3 to to TO cord-005453-4057qib7 3180 4 build build VB cord-005453-4057qib7 3180 5 more more RBR cord-005453-4057qib7 3180 6 active active JJ cord-005453-4057qib7 3180 7 survivorship survivorship NN cord-005453-4057qib7 3180 8 care care NN cord-005453-4057qib7 3180 9 plan plan NN cord-005453-4057qib7 3180 10 after after IN cord-005453-4057qib7 3180 11 allo allo NN cord-005453-4057qib7 3180 12 - - HYPH cord-005453-4057qib7 3180 13 HCT HCT NNP cord-005453-4057qib7 3180 14 especially especially RB cord-005453-4057qib7 3180 15 for for IN cord-005453-4057qib7 3180 16 those those DT cord-005453-4057qib7 3180 17 patients patient NNS cord-005453-4057qib7 3180 18 . . . cord-005453-4057qib7 3181 1 Disclosure disclosure NN cord-005453-4057qib7 3181 2 : : : cord-005453-4057qib7 3182 1 All all DT cord-005453-4057qib7 3182 2 authors author NNS cord-005453-4057qib7 3182 3 have have VBP cord-005453-4057qib7 3182 4 nothing nothing NN cord-005453-4057qib7 3182 5 to to TO cord-005453-4057qib7 3182 6 declare declare VB cord-005453-4057qib7 3182 7 . . . cord-005453-4057qib7 3183 1 Evaluation evaluation NN cord-005453-4057qib7 3183 2 of of IN cord-005453-4057qib7 3183 3 the the DT cord-005453-4057qib7 3183 4 new new JJ cord-005453-4057qib7 3183 5 EBMT EBMT NNP cord-005453-4057qib7 3183 6 criteria criterion NNS cord-005453-4057qib7 3183 7 for for IN cord-005453-4057qib7 3183 8 the the DT cord-005453-4057qib7 3183 9 diagnosis diagnosis NN cord-005453-4057qib7 3183 10 of of IN cord-005453-4057qib7 3183 11 VOD VOD NNP cord-005453-4057qib7 3183 12 / / SYM cord-005453-4057qib7 3183 13 SOS SOS NNP cord-005453-4057qib7 3183 14 in in IN cord-005453-4057qib7 3183 15 693 693 CD cord-005453-4057qib7 3183 16 consecutive consecutive JJ cord-005453-4057qib7 3183 17 transplant transplant NN cord-005453-4057qib7 3183 18 patients patient NNS cord-005453-4057qib7 3183 19 using use VBG cord-005453-4057qib7 3183 20 an an DT cord-005453-4057qib7 3183 21 electronic electronic JJ cord-005453-4057qib7 3183 22 patient patient NN cord-005453-4057qib7 3183 23 record record NN cord-005453-4057qib7 3183 24 analysis analysis NN cord-005453-4057qib7 3183 25 system system NN cord-005453-4057qib7 3183 26 Asha Asha NNP cord-005453-4057qib7 3183 27 Aggarwal Aggarwal NNP cord-005453-4057qib7 3183 28 1 1 CD cord-005453-4057qib7 3183 29 , , , cord-005453-4057qib7 3183 30 Nicola Nicola NNP cord-005453-4057qib7 3183 31 Gray Gray NNP cord-005453-4057qib7 3183 32 1 1 CD cord-005453-4057qib7 3183 33 , , , cord-005453-4057qib7 3183 34 Oliver Oliver NNP cord-005453-4057qib7 3183 35 Lomas Lomas NNP cord-005453-4057qib7 3183 36 1 1 CD cord-005453-4057qib7 3183 37 , , , cord-005453-4057qib7 3183 38 Katalin Katalin NNP cord-005453-4057qib7 3183 39 Balassa Balassa NNP cord-005453-4057qib7 3183 40 1 1 CD cord-005453-4057qib7 3183 41 , , , cord-005453-4057qib7 3183 42 Nadjoua Nadjoua NNP cord-005453-4057qib7 3183 43 Maouche Maouche NNP cord-005453-4057qib7 3183 44 1 1 CD cord-005453-4057qib7 3183 45 , , , cord-005453-4057qib7 3183 46 Robert Robert NNP cord-005453-4057qib7 3183 47 Danby Danby NNP cord-005453-4057qib7 3183 48 1,2 1,2 CD cord-005453-4057qib7 3183 49 , , , cord-005453-4057qib7 3183 50 Andy Andy NNP cord-005453-4057qib7 3183 51 Peniket Peniket NNP cord-005453-4057qib7 3183 52 1 1 CD cord-005453-4057qib7 3183 53 , , , cord-005453-4057qib7 3183 54 Grant Grant NNP cord-005453-4057qib7 3183 55 Vallance Vallance NNP cord-005453-4057qib7 3183 56 1 1 CD cord-005453-4057qib7 3183 57 Background Background NNP cord-005453-4057qib7 3183 58 : : : cord-005453-4057qib7 3183 59 Veno Veno NNP cord-005453-4057qib7 3183 60 - - HYPH cord-005453-4057qib7 3183 61 Occlusive Occlusive NNP cord-005453-4057qib7 3183 62 disease disease NN cord-005453-4057qib7 3183 63 ( ( -LRB- cord-005453-4057qib7 3183 64 VOD VOD NNP cord-005453-4057qib7 3183 65 ) ) -RRB- cord-005453-4057qib7 3183 66 , , , cord-005453-4057qib7 3183 67 or or CC cord-005453-4057qib7 3183 68 sinusoidal sinusoidal JJ cord-005453-4057qib7 3183 69 obstruction obstruction NN cord-005453-4057qib7 3183 70 syndrome syndrome NN cord-005453-4057qib7 3183 71 ( ( -LRB- cord-005453-4057qib7 3183 72 SOS SOS NNP cord-005453-4057qib7 3183 73 ) ) -RRB- cord-005453-4057qib7 3183 74 , , , cord-005453-4057qib7 3183 75 is be VBZ cord-005453-4057qib7 3183 76 a a DT cord-005453-4057qib7 3183 77 recognised recognise VBN cord-005453-4057qib7 3183 78 complication complication NN cord-005453-4057qib7 3183 79 of of IN cord-005453-4057qib7 3183 80 haematopoietic haematopoietic JJ cord-005453-4057qib7 3183 81 stem stem NN cord-005453-4057qib7 3183 82 cell cell NN cord-005453-4057qib7 3183 83 transplantation transplantation NN cord-005453-4057qib7 3183 84 . . . cord-005453-4057qib7 3184 1 Hepatic hepatic JJ cord-005453-4057qib7 3184 2 vasculature vasculature NN cord-005453-4057qib7 3184 3 endothelial endothelial JJ cord-005453-4057qib7 3184 4 cells cell NNS cord-005453-4057qib7 3184 5 are be VBP cord-005453-4057qib7 3184 6 damaged damage VBN cord-005453-4057qib7 3184 7 by by IN cord-005453-4057qib7 3184 8 conditioning conditioning NN cord-005453-4057qib7 3184 9 chemotherapy chemotherapy NN cord-005453-4057qib7 3184 10 , , , cord-005453-4057qib7 3184 11 leading lead VBG cord-005453-4057qib7 3184 12 to to IN cord-005453-4057qib7 3184 13 venous venous JJ cord-005453-4057qib7 3184 14 occlusion occlusion NN cord-005453-4057qib7 3184 15 and and CC cord-005453-4057qib7 3184 16 centrilobar centrilobar NN cord-005453-4057qib7 3184 17 necrosis necrosis NN cord-005453-4057qib7 3184 18 . . . cord-005453-4057qib7 3185 1 The the DT cord-005453-4057qib7 3185 2 EBMT EBMT NNP cord-005453-4057qib7 3185 3 criteria criterion NNS cord-005453-4057qib7 3185 4 for for IN cord-005453-4057qib7 3185 5 diagnosis diagnosis NN cord-005453-4057qib7 3185 6 of of IN cord-005453-4057qib7 3185 7 VOD VOD NNP cord-005453-4057qib7 3185 8 are be VBP cord-005453-4057qib7 3185 9 bilirubin bilirubin NN cord-005453-4057qib7 3185 10 > > XX cord-005453-4057qib7 3185 11 = = SYM cord-005453-4057qib7 3185 12 34 34 CD cord-005453-4057qib7 3185 13 with with IN cord-005453-4057qib7 3185 14 two two CD cord-005453-4057qib7 3185 15 of of IN cord-005453-4057qib7 3185 16 painful painful JJ cord-005453-4057qib7 3185 17 hepatomegaly hepatomegaly NNP cord-005453-4057qib7 3185 18 , , . cord-005453-4057qib7 3186 1 > > XX cord-005453-4057qib7 3186 2 5 5 CD cord-005453-4057qib7 3186 3 % % NN cord-005453-4057qib7 3186 4 weight weight NN cord-005453-4057qib7 3186 5 gain gain NN cord-005453-4057qib7 3186 6 and and CC cord-005453-4057qib7 3186 7 ascites ascites NN cord-005453-4057qib7 3186 8 . . . cord-005453-4057qib7 3187 1 VOD VOD NNP cord-005453-4057qib7 3187 2 is be VBZ cord-005453-4057qib7 3187 3 often often RB cord-005453-4057qib7 3187 4 under under RB cord-005453-4057qib7 3187 5 - - HYPH cord-005453-4057qib7 3187 6 diagnosed diagnose VBN cord-005453-4057qib7 3187 7 , , , cord-005453-4057qib7 3187 8 and and CC cord-005453-4057qib7 3187 9 as as IN cord-005453-4057qib7 3187 10 a a DT cord-005453-4057qib7 3187 11 result result NN cord-005453-4057qib7 3187 12 , , , cord-005453-4057qib7 3187 13 treatment treatment NN cord-005453-4057qib7 3187 14 may may MD cord-005453-4057qib7 3187 15 be be VB cord-005453-4057qib7 3187 16 delayed delay VBN cord-005453-4057qib7 3187 17 . . . cord-005453-4057qib7 3188 1 Integrated integrate VBN cord-005453-4057qib7 3188 2 electronic electronic JJ cord-005453-4057qib7 3188 3 patient patient NN cord-005453-4057qib7 3188 4 record record NN cord-005453-4057qib7 3188 5 ( ( -LRB- cord-005453-4057qib7 3188 6 EPR EPR NNP cord-005453-4057qib7 3188 7 ) ) -RRB- cord-005453-4057qib7 3188 8 systems system NNS cord-005453-4057qib7 3188 9 are be VBP cord-005453-4057qib7 3188 10 now now RB cord-005453-4057qib7 3188 11 widely widely RB cord-005453-4057qib7 3188 12 used use VBN cord-005453-4057qib7 3188 13 , , , cord-005453-4057qib7 3188 14 and and CC cord-005453-4057qib7 3188 15 provide provide VB cord-005453-4057qib7 3188 16 an an DT cord-005453-4057qib7 3188 17 opportunity opportunity NN cord-005453-4057qib7 3188 18 to to TO cord-005453-4057qib7 3188 19 retrospectively retrospectively RB cord-005453-4057qib7 3188 20 audit audit VB cord-005453-4057qib7 3188 21 practice practice NN cord-005453-4057qib7 3188 22 to to TO cord-005453-4057qib7 3188 23 identify identify VB cord-005453-4057qib7 3188 24 patients patient NNS cord-005453-4057qib7 3188 25 in in IN cord-005453-4057qib7 3188 26 whom whom WP cord-005453-4057qib7 3188 27 VOD VOD NNP cord-005453-4057qib7 3188 28 may may MD cord-005453-4057qib7 3188 29 have have VB cord-005453-4057qib7 3188 30 been be VBN cord-005453-4057qib7 3188 31 un un NNP cord-005453-4057qib7 3188 32 - - JJ cord-005453-4057qib7 3188 33 diagnosed diagnose VBN cord-005453-4057qib7 3188 34 or or CC cord-005453-4057qib7 3188 35 in in IN cord-005453-4057qib7 3188 36 whom whom WP cord-005453-4057qib7 3188 37 treatment treatment NN cord-005453-4057qib7 3188 38 was be VBD cord-005453-4057qib7 3188 39 delayed delay VBN cord-005453-4057qib7 3188 40 . . . cord-005453-4057qib7 3189 1 In in IN cord-005453-4057qib7 3189 2 addition addition NN cord-005453-4057qib7 3189 3 these these DT cord-005453-4057qib7 3189 4 systems system NNS cord-005453-4057qib7 3189 5 have have VBP cord-005453-4057qib7 3189 6 potential potential NN cord-005453-4057qib7 3189 7 for for IN cord-005453-4057qib7 3189 8 alerting alert VBG cord-005453-4057qib7 3189 9 clinicians clinician NNS cord-005453-4057qib7 3189 10 to to IN cord-005453-4057qib7 3189 11 the the DT cord-005453-4057qib7 3189 12 potential potential JJ cord-005453-4057qib7 3189 13 diagnosis diagnosis NN cord-005453-4057qib7 3189 14 of of IN cord-005453-4057qib7 3189 15 VOD VOD NNP cord-005453-4057qib7 3189 16 . . . cord-005453-4057qib7 3190 1 Methods method NNS cord-005453-4057qib7 3190 2 : : : cord-005453-4057qib7 3191 1 We -PRON- PRP cord-005453-4057qib7 3191 2 have have VBP cord-005453-4057qib7 3191 3 developed develop VBN cord-005453-4057qib7 3191 4 software software NN cord-005453-4057qib7 3191 5 to to TO cord-005453-4057qib7 3191 6 analyse analyse VB cord-005453-4057qib7 3191 7 the the DT cord-005453-4057qib7 3191 8 data datum NNS cord-005453-4057qib7 3191 9 downloaded download VBN cord-005453-4057qib7 3191 10 from from IN cord-005453-4057qib7 3191 11 EPR EPR NNP cord-005453-4057qib7 3191 12 to to TO cord-005453-4057qib7 3191 13 identify identify VB cord-005453-4057qib7 3191 14 patients patient NNS cord-005453-4057qib7 3191 15 in in IN cord-005453-4057qib7 3191 16 whom whom WP cord-005453-4057qib7 3191 17 VOD VOD NNP cord-005453-4057qib7 3191 18 was be VBD cord-005453-4057qib7 3191 19 a a DT cord-005453-4057qib7 3191 20 possible possible JJ cord-005453-4057qib7 3191 21 diagnosis diagnosis NN cord-005453-4057qib7 3191 22 according accord VBG cord-005453-4057qib7 3191 23 to to IN cord-005453-4057qib7 3191 24 the the DT cord-005453-4057qib7 3191 25 new new JJ cord-005453-4057qib7 3191 26 EBMT EBMT NNP cord-005453-4057qib7 3191 27 criteria criterion NNS cord-005453-4057qib7 3191 28 . . . cord-005453-4057qib7 3192 1 In in IN cord-005453-4057qib7 3192 2 order order NN cord-005453-4057qib7 3192 3 to to TO cord-005453-4057qib7 3192 4 identify identify VB cord-005453-4057qib7 3192 5 patients patient NNS cord-005453-4057qib7 3192 6 who who WP cord-005453-4057qib7 3192 7 may may MD cord-005453-4057qib7 3192 8 have have VB cord-005453-4057qib7 3192 9 had have VBN cord-005453-4057qib7 3192 10 VOD VOD NNP cord-005453-4057qib7 3192 11 we -PRON- PRP cord-005453-4057qib7 3192 12 first first RB cord-005453-4057qib7 3192 13 screened screen VBD cord-005453-4057qib7 3192 14 for for IN cord-005453-4057qib7 3192 15 patients patient NNS cord-005453-4057qib7 3192 16 with with IN cord-005453-4057qib7 3192 17 a a DT cord-005453-4057qib7 3192 18 bilirubin bilirubin NN cord-005453-4057qib7 3192 19 of of IN cord-005453-4057qib7 3192 20 > > XX cord-005453-4057qib7 3192 21 = = SYM cord-005453-4057qib7 3192 22 34 34 CD cord-005453-4057qib7 3192 23 mmol mmol NNP cord-005453-4057qib7 3192 24 / / SYM cord-005453-4057qib7 3192 25 l l NN cord-005453-4057qib7 3192 26 ( ( -LRB- cord-005453-4057qib7 3192 27 which which WDT cord-005453-4057qib7 3192 28 is be VBZ cord-005453-4057qib7 3192 29 an an DT cord-005453-4057qib7 3192 30 absolute absolute JJ cord-005453-4057qib7 3192 31 requirement requirement NN cord-005453-4057qib7 3192 32 for for IN cord-005453-4057qib7 3192 33 the the DT cord-005453-4057qib7 3192 34 clinical clinical JJ cord-005453-4057qib7 3192 35 diagnosis diagnosis NN cord-005453-4057qib7 3192 36 of of IN cord-005453-4057qib7 3192 37 VOD VOD NNP cord-005453-4057qib7 3192 38 ) ) -RRB- cord-005453-4057qib7 3192 39 within within IN cord-005453-4057qib7 3192 40 the the DT cord-005453-4057qib7 3192 41 first first JJ cord-005453-4057qib7 3192 42 50 50 CD cord-005453-4057qib7 3192 43 days day NNS cord-005453-4057qib7 3192 44 of of IN cord-005453-4057qib7 3192 45 transplantation transplantation NN cord-005453-4057qib7 3192 46 . . . cord-005453-4057qib7 3193 1 EPR EPR NNP cord-005453-4057qib7 3193 2 data datum NNS cord-005453-4057qib7 3193 3 was be VBD cord-005453-4057qib7 3193 4 then then RB cord-005453-4057qib7 3193 5 used use VBN cord-005453-4057qib7 3193 6 to to TO cord-005453-4057qib7 3193 7 assess assess VB cord-005453-4057qib7 3193 8 whether whether IN cord-005453-4057qib7 3193 9 patients patient NNS cord-005453-4057qib7 3193 10 had have VBD cord-005453-4057qib7 3193 11 > > $ cord-005453-4057qib7 3193 12 5 5 CD cord-005453-4057qib7 3193 13 % % NN cord-005453-4057qib7 3193 14 weight weight NN cord-005453-4057qib7 3193 15 gain gain NN cord-005453-4057qib7 3193 16 . . . cord-005453-4057qib7 3194 1 Radiology radiology NN cord-005453-4057qib7 3194 2 reports report NNS cord-005453-4057qib7 3194 3 were be VBD cord-005453-4057qib7 3194 4 reviewed review VBN cord-005453-4057qib7 3194 5 for for IN cord-005453-4057qib7 3194 6 patients patient NNS cord-005453-4057qib7 3194 7 who who WP cord-005453-4057qib7 3194 8 had have VBD cord-005453-4057qib7 3194 9 bilirubin bilirubin NN cord-005453-4057qib7 3194 10 > > XX cord-005453-4057qib7 3194 11 = = SYM cord-005453-4057qib7 3194 12 34 34 CD cord-005453-4057qib7 3194 13 mmol mmol NNP cord-005453-4057qib7 3194 14 / / SYM cord-005453-4057qib7 3194 15 L L NNP cord-005453-4057qib7 3194 16 to to TO cord-005453-4057qib7 3194 17 ascertain ascertain VB cord-005453-4057qib7 3194 18 if if IN cord-005453-4057qib7 3194 19 they -PRON- PRP cord-005453-4057qib7 3194 20 revealed reveal VBD cord-005453-4057qib7 3194 21 ascites ascite NNS cord-005453-4057qib7 3194 22 or or CC cord-005453-4057qib7 3194 23 painful painful JJ cord-005453-4057qib7 3194 24 hepatomegaly hepatomegaly NNS cord-005453-4057qib7 3194 25 . . . cord-005453-4057qib7 3195 1 Results result NNS cord-005453-4057qib7 3195 2 : : : cord-005453-4057qib7 3196 1 652 652 CD cord-005453-4057qib7 3196 2 patients patient NNS cord-005453-4057qib7 3196 3 underwent undergo VBD cord-005453-4057qib7 3196 4 693 693 CD cord-005453-4057qib7 3196 5 transplant transplant NN cord-005453-4057qib7 3196 6 procedures procedure NNS cord-005453-4057qib7 3196 7 ( ( -LRB- cord-005453-4057qib7 3196 8 January January NNP cord-005453-4057qib7 3196 9 1st 1st NN cord-005453-4057qib7 3196 10 2013 2013 CD cord-005453-4057qib7 3196 11 to to IN cord-005453-4057qib7 3196 12 July July NNP cord-005453-4057qib7 3196 13 31st 31st NN cord-005453-4057qib7 3196 14 2018 2018 CD cord-005453-4057qib7 3196 15 ) ) -RRB- cord-005453-4057qib7 3196 16 . . . cord-005453-4057qib7 3197 1 162 162 CD cord-005453-4057qib7 3197 2 of of IN cord-005453-4057qib7 3197 3 all all DT cord-005453-4057qib7 3197 4 transplant transplant NN cord-005453-4057qib7 3197 5 patients patient NNS cord-005453-4057qib7 3197 6 ( ( -LRB- cord-005453-4057qib7 3197 7 23.4 23.4 CD cord-005453-4057qib7 3197 8 % % NN cord-005453-4057qib7 3197 9 ) ) -RRB- cord-005453-4057qib7 3197 10 were be VBD cord-005453-4057qib7 3197 11 found find VBN cord-005453-4057qib7 3197 12 to to TO cord-005453-4057qib7 3197 13 have have VB cord-005453-4057qib7 3197 14 a a DT cord-005453-4057qib7 3197 15 bilirubin bilirubin NN cord-005453-4057qib7 3197 16 of of IN cord-005453-4057qib7 3197 17 > > XX cord-005453-4057qib7 3197 18 = = SYM cord-005453-4057qib7 3197 19 34 34 CD cord-005453-4057qib7 3197 20 mmol mmol NNP cord-005453-4057qib7 3197 21 / / SYM cord-005453-4057qib7 3197 22 l l NN cord-005453-4057qib7 3197 23 . . NNP cord-005453-4057qib7 3197 24 39 39 CD cord-005453-4057qib7 3197 25 of of IN cord-005453-4057qib7 3197 26 403 403 CD cord-005453-4057qib7 3197 27 ( ( -LRB- cord-005453-4057qib7 3197 28 9.6 9.6 CD cord-005453-4057qib7 3197 29 % % NN cord-005453-4057qib7 3197 30 ) ) -RRB- cord-005453-4057qib7 3197 31 autograft autograft NN cord-005453-4057qib7 3197 32 patients patient NNS cord-005453-4057qib7 3197 33 and and CC cord-005453-4057qib7 3197 34 123 123 CD cord-005453-4057qib7 3197 35 of of IN cord-005453-4057qib7 3197 36 249 249 CD cord-005453-4057qib7 3197 37 ( ( -LRB- cord-005453-4057qib7 3197 38 49.4 49.4 CD cord-005453-4057qib7 3197 39 % % NN cord-005453-4057qib7 3197 40 ) ) -RRB- cord-005453-4057qib7 3197 41 allograft allograft NN cord-005453-4057qib7 3197 42 patients patient NNS cord-005453-4057qib7 3197 43 had have VBD cord-005453-4057qib7 3197 44 an an DT cord-005453-4057qib7 3197 45 elevated elevated JJ cord-005453-4057qib7 3197 46 bilirubin bilirubin NN cord-005453-4057qib7 3197 47 at at IN cord-005453-4057qib7 3197 48 this this DT cord-005453-4057qib7 3197 49 level level NN cord-005453-4057qib7 3197 50 . . . cord-005453-4057qib7 3198 1 These these DT cord-005453-4057qib7 3198 2 162 162 CD cord-005453-4057qib7 3198 3 patients patient NNS cord-005453-4057qib7 3198 4 were be VBD cord-005453-4057qib7 3198 5 assessed assess VBN cord-005453-4057qib7 3198 6 for for IN cord-005453-4057qib7 3198 7 evidence evidence NN cord-005453-4057qib7 3198 8 of of IN cord-005453-4057qib7 3198 9 5 5 CD cord-005453-4057qib7 3198 10 % % NN cord-005453-4057qib7 3198 11 weight weight NN cord-005453-4057qib7 3198 12 gain gain NN cord-005453-4057qib7 3198 13 . . . cord-005453-4057qib7 3199 1 This this DT cord-005453-4057qib7 3199 2 was be VBD cord-005453-4057qib7 3199 3 the the DT cord-005453-4057qib7 3199 4 case case NN cord-005453-4057qib7 3199 5 in in IN cord-005453-4057qib7 3199 6 30 30 CD cord-005453-4057qib7 3199 7 patients patient NNS cord-005453-4057qib7 3199 8 overall-1 overall-1 IN cord-005453-4057qib7 3199 9 % % NN cord-005453-4057qib7 3199 10 of of IN cord-005453-4057qib7 3199 11 autograft autograft NN cord-005453-4057qib7 3199 12 patients patient NNS cord-005453-4057qib7 3199 13 , , , cord-005453-4057qib7 3199 14 10.5 10.5 CD cord-005453-4057qib7 3199 15 % % NN cord-005453-4057qib7 3199 16 of of IN cord-005453-4057qib7 3199 17 allograft allograft NN cord-005453-4057qib7 3199 18 patients patient NNS cord-005453-4057qib7 3199 19 . . . cord-005453-4057qib7 3200 1 Seven seven CD cord-005453-4057qib7 3200 2 patients patient NNS cord-005453-4057qib7 3200 3 ( ( -LRB- cord-005453-4057qib7 3200 4 2 2 CD cord-005453-4057qib7 3200 5 autograft autograft NN cord-005453-4057qib7 3200 6 and and CC cord-005453-4057qib7 3200 7 5 5 CD cord-005453-4057qib7 3200 8 allograft allograft NN cord-005453-4057qib7 3200 9 ) ) -RRB- cord-005453-4057qib7 3200 10 had have VBD cord-005453-4057qib7 3200 11 radiological radiological JJ cord-005453-4057qib7 3200 12 evidence evidence NN cord-005453-4057qib7 3200 13 of of IN cord-005453-4057qib7 3200 14 ascites ascite NNS cord-005453-4057qib7 3200 15 . . . cord-005453-4057qib7 3201 1 Two two CD cord-005453-4057qib7 3201 2 patients patient NNS cord-005453-4057qib7 3201 3 had have VBD cord-005453-4057qib7 3201 4 a a DT cord-005453-4057qib7 3201 5 recording recording NN cord-005453-4057qib7 3201 6 of of IN cord-005453-4057qib7 3201 7 painful painful JJ cord-005453-4057qib7 3201 8 hepatomegaly hepatomegaly NNP cord-005453-4057qib7 3201 9 ( ( -LRB- cord-005453-4057qib7 3201 10 both both DT cord-005453-4057qib7 3201 11 post post NN cord-005453-4057qib7 3201 12 allograft allograft NN cord-005453-4057qib7 3201 13 ) ) -RRB- cord-005453-4057qib7 3201 14 . . . cord-005453-4057qib7 3202 1 Overall overall JJ cord-005453-4057qib7 3202 2 our -PRON- PRP$ cord-005453-4057qib7 3202 3 analysis analysis NN cord-005453-4057qib7 3202 4 identified identify VBD cord-005453-4057qib7 3202 5 5 5 CD cord-005453-4057qib7 3202 6 patients patient NNS cord-005453-4057qib7 3202 7 ( ( -LRB- cord-005453-4057qib7 3202 8 0.7 0.7 CD cord-005453-4057qib7 3202 9 % % NN cord-005453-4057qib7 3202 10 overall overall NN cord-005453-4057qib7 3202 11 ) ) -RRB- cord-005453-4057qib7 3202 12 fulfilling fulfil VBG cord-005453-4057qib7 3202 13 the the DT cord-005453-4057qib7 3202 14 EBMT EBMT NNP cord-005453-4057qib7 3202 15 diagnostic diagnostic JJ cord-005453-4057qib7 3202 16 criteria criterion NNS cord-005453-4057qib7 3202 17 for for IN cord-005453-4057qib7 3202 18 classic classic JJ cord-005453-4057qib7 3202 19 early early JJ cord-005453-4057qib7 3202 20 VOD VOD NNP cord-005453-4057qib7 3202 21 all all DT cord-005453-4057qib7 3202 22 of of IN cord-005453-4057qib7 3202 23 whom whom WP cord-005453-4057qib7 3202 24 received receive VBD cord-005453-4057qib7 3202 25 defibrotide defibrotide NN cord-005453-4057qib7 3202 26 . . . cord-005453-4057qib7 3203 1 All all DT cord-005453-4057qib7 3203 2 patients patient NNS cord-005453-4057qib7 3203 3 had have VBD cord-005453-4057qib7 3203 4 received receive VBN cord-005453-4057qib7 3203 5 allogeneic allogeneic IN cord-005453-4057qib7 3203 6 transplants transplant NNS cord-005453-4057qib7 3203 7 . . . cord-005453-4057qib7 3204 1 We -PRON- PRP cord-005453-4057qib7 3204 2 failed fail VBD cord-005453-4057qib7 3204 3 to to TO cord-005453-4057qib7 3204 4 identify identify VB cord-005453-4057qib7 3204 5 any any DT cord-005453-4057qib7 3204 6 cases case NNS cord-005453-4057qib7 3204 7 of of IN cord-005453-4057qib7 3204 8 late late JJ cord-005453-4057qib7 3204 9 onset onset NN cord-005453-4057qib7 3204 10 VOD vod NN cord-005453-4057qib7 3204 11 or or CC cord-005453-4057qib7 3204 12 any any DT cord-005453-4057qib7 3204 13 undiagnosed undiagnosed JJ cord-005453-4057qib7 3204 14 patients patient NNS cord-005453-4057qib7 3204 15 over over IN cord-005453-4057qib7 3204 16 this this DT cord-005453-4057qib7 3204 17 period period NN cord-005453-4057qib7 3204 18 . . . cord-005453-4057qib7 3205 1 Conclusions conclusion NNS cord-005453-4057qib7 3205 2 : : : cord-005453-4057qib7 3206 1 This this DT cord-005453-4057qib7 3206 2 analysis analysis NN cord-005453-4057qib7 3206 3 enabled enable VBD cord-005453-4057qib7 3206 4 us -PRON- PRP cord-005453-4057qib7 3206 5 to to TO cord-005453-4057qib7 3206 6 efficiently efficiently RB cord-005453-4057qib7 3206 7 perform perform VB cord-005453-4057qib7 3206 8 a a DT cord-005453-4057qib7 3206 9 complete complete JJ cord-005453-4057qib7 3206 10 audit audit NN cord-005453-4057qib7 3206 11 of of IN cord-005453-4057qib7 3206 12 our -PRON- PRP$ cord-005453-4057qib7 3206 13 practice practice NN cord-005453-4057qib7 3206 14 to to TO cord-005453-4057qib7 3206 15 identify identify VB cord-005453-4057qib7 3206 16 patients patient NNS cord-005453-4057qib7 3206 17 with with IN cord-005453-4057qib7 3206 18 VOD VOD NNP cord-005453-4057qib7 3206 19 . . . cord-005453-4057qib7 3207 1 We -PRON- PRP cord-005453-4057qib7 3207 2 would would MD cord-005453-4057qib7 3207 3 recommend recommend VB cord-005453-4057qib7 3207 4 using use VBG cord-005453-4057qib7 3207 5 electronic electronic JJ cord-005453-4057qib7 3207 6 patient patient NN cord-005453-4057qib7 3207 7 records record NNS cord-005453-4057qib7 3207 8 to to TO cord-005453-4057qib7 3207 9 retrospectively retrospectively RB cord-005453-4057qib7 3207 10 audit audit VB cord-005453-4057qib7 3207 11 practice practice NN cord-005453-4057qib7 3207 12 in in IN cord-005453-4057qib7 3207 13 this this DT cord-005453-4057qib7 3207 14 way way NN cord-005453-4057qib7 3207 15 . . . cord-005453-4057qib7 3208 1 The the DT cord-005453-4057qib7 3208 2 tool tool NN cord-005453-4057qib7 3208 3 that that WDT cord-005453-4057qib7 3208 4 we -PRON- PRP cord-005453-4057qib7 3208 5 have have VBP cord-005453-4057qib7 3208 6 created create VBN cord-005453-4057qib7 3208 7 for for IN cord-005453-4057qib7 3208 8 this this DT cord-005453-4057qib7 3208 9 analysis analysis NN cord-005453-4057qib7 3208 10 will will MD cord-005453-4057qib7 3208 11 be be VB cord-005453-4057qib7 3208 12 made make VBN cord-005453-4057qib7 3208 13 freely freely RB cord-005453-4057qib7 3208 14 available available JJ cord-005453-4057qib7 3208 15 for for IN cord-005453-4057qib7 3208 16 public public JJ cord-005453-4057qib7 3208 17 use use NN cord-005453-4057qib7 3208 18 and and CC cord-005453-4057qib7 3208 19 the the DT cord-005453-4057qib7 3208 20 details detail NNS cord-005453-4057qib7 3208 21 will will MD cord-005453-4057qib7 3208 22 be be VB cord-005453-4057qib7 3208 23 presented present VBN cord-005453-4057qib7 3208 24 at at IN cord-005453-4057qib7 3208 25 the the DT cord-005453-4057qib7 3208 26 EBMT EBMT NNP cord-005453-4057qib7 3208 27 meeting meeting NN cord-005453-4057qib7 3208 28 . . . cord-005453-4057qib7 3209 1 We -PRON- PRP cord-005453-4057qib7 3209 2 now now RB cord-005453-4057qib7 3209 3 plan plan VBP cord-005453-4057qib7 3209 4 to to TO cord-005453-4057qib7 3209 5 extend extend VB cord-005453-4057qib7 3209 6 the the DT cord-005453-4057qib7 3209 7 function function NN cord-005453-4057qib7 3209 8 of of IN cord-005453-4057qib7 3209 9 our -PRON- PRP$ cord-005453-4057qib7 3209 10 EPR EPR NNP cord-005453-4057qib7 3209 11 system system NN cord-005453-4057qib7 3209 12 to to TO cord-005453-4057qib7 3209 13 provide provide VB cord-005453-4057qib7 3209 14 alerts alert NNS cord-005453-4057qib7 3209 15 to to IN cord-005453-4057qib7 3209 16 clinicians clinician NNS cord-005453-4057qib7 3209 17 when when WRB cord-005453-4057qib7 3209 18 VOD VOD NNP cord-005453-4057qib7 3209 19 is be VBZ cord-005453-4057qib7 3209 20 a a DT cord-005453-4057qib7 3209 21 possible possible JJ cord-005453-4057qib7 3209 22 diagnosis diagnosis NN cord-005453-4057qib7 3209 23 and and CC cord-005453-4057qib7 3209 24 may may MD cord-005453-4057qib7 3209 25 lead lead VB cord-005453-4057qib7 3209 26 to to IN cord-005453-4057qib7 3209 27 more more RBR cord-005453-4057qib7 3209 28 rapid rapid JJ cord-005453-4057qib7 3209 29 treatment treatment NN cord-005453-4057qib7 3209 30 of of IN cord-005453-4057qib7 3209 31 these these DT cord-005453-4057qib7 3209 32 patients patient NNS cord-005453-4057qib7 3209 33 . . . cord-005453-4057qib7 3210 1 Our -PRON- PRP$ cord-005453-4057qib7 3210 2 data data NN cord-005453-4057qib7 3210 3 suggests suggest VBZ cord-005453-4057qib7 3210 4 that that IN cord-005453-4057qib7 3210 5 elevation elevation NN cord-005453-4057qib7 3210 6 of of IN cord-005453-4057qib7 3210 7 bilirubin bilirubin NN cord-005453-4057qib7 3210 8 and and CC cord-005453-4057qib7 3210 9 weight weight NN cord-005453-4057qib7 3210 10 gain gain NN cord-005453-4057qib7 3210 11 of of IN cord-005453-4057qib7 3210 12 > > $ cord-005453-4057qib7 3210 13 5 5 CD cord-005453-4057qib7 3210 14 % % NN cord-005453-4057qib7 3210 15 will will MD cord-005453-4057qib7 3210 16 be be VB cord-005453-4057qib7 3210 17 the the DT cord-005453-4057qib7 3210 18 most most RBS cord-005453-4057qib7 3210 19 frequently frequently RB cord-005453-4057qib7 3210 20 occurring occur VBG cord-005453-4057qib7 3210 21 criteria criterion NNS cord-005453-4057qib7 3210 22 on on IN cord-005453-4057qib7 3210 23 which which WDT cord-005453-4057qib7 3210 24 to to TO cord-005453-4057qib7 3210 25 base base VB cord-005453-4057qib7 3210 26 these these DT cord-005453-4057qib7 3210 27 alerts alert NNS cord-005453-4057qib7 3210 28 . . . cord-005453-4057qib7 3211 1 Disclosure disclosure NN cord-005453-4057qib7 3211 2 : : : cord-005453-4057qib7 3211 3 G.Vallance G.Vallance NNP cord-005453-4057qib7 3211 4 has have VBZ cord-005453-4057qib7 3211 5 performed perform VBN cord-005453-4057qib7 3211 6 consultancy consultancy NN cord-005453-4057qib7 3211 7 work work NN cord-005453-4057qib7 3211 8 for for IN cord-005453-4057qib7 3211 9 Jazz jazz NN cord-005453-4057qib7 3211 10 pharmaceuticals pharmaceutical NNS cord-005453-4057qib7 3211 11 . . . cord-005453-4057qib7 3212 1 Endothelial endothelial JJ cord-005453-4057qib7 3212 2 activation activation NN cord-005453-4057qib7 3212 3 and and CC cord-005453-4057qib7 3212 4 stress stress NN cord-005453-4057qib7 3212 5 index index NN cord-005453-4057qib7 3212 6 in in IN cord-005453-4057qib7 3212 7 predicting predict VBG cord-005453-4057qib7 3212 8 outcome outcome NN cord-005453-4057qib7 3212 9 of of IN cord-005453-4057qib7 3212 10 allogeneic allogeneic NN cord-005453-4057qib7 3212 11 stem stem NN cord-005453-4057qib7 3212 12 cell cell NN cord-005453-4057qib7 3212 13 transplantation transplantation NN cord-005453-4057qib7 3213 1 -A -A : cord-005453-4057qib7 3213 2 retrospective retrospective JJ cord-005453-4057qib7 3213 3 cohort cohort NN cord-005453-4057qib7 3213 4 analysis analysis NN cord-005453-4057qib7 3213 5 Zinaida Zinaida NNP cord-005453-4057qib7 3213 6 Peric Peric NNP cord-005453-4057qib7 3213 7 1 1 CD cord-005453-4057qib7 3213 8 , , , cord-005453-4057qib7 3213 9 Tomislav Tomislav NNP cord-005453-4057qib7 3213 10 Taborsak Taborsak NNP cord-005453-4057qib7 3213 11 1 1 CD cord-005453-4057qib7 3213 12 , , , cord-005453-4057qib7 3213 13 Nadira Nadira NNP cord-005453-4057qib7 3213 14 Durakovic Durakovic NNP cord-005453-4057qib7 3213 15 1 1 CD cord-005453-4057qib7 3213 16 , , , cord-005453-4057qib7 3213 17 Lana Lana NNP cord-005453-4057qib7 3213 18 Desnica Desnica NNP cord-005453-4057qib7 3213 19 1 1 CD cord-005453-4057qib7 3213 20 , , , cord-005453-4057qib7 3213 21 Alen Alen NNP cord-005453-4057qib7 3213 22 Ostojic Ostojic NNP cord-005453-4057qib7 3213 23 1 1 CD cord-005453-4057qib7 3213 24 , , , cord-005453-4057qib7 3213 25 Ranka Ranka NNP cord-005453-4057qib7 3213 26 Serventi Serventi NNP cord-005453-4057qib7 3213 27 - - HYPH cord-005453-4057qib7 3213 28 Seiwerth Seiwerth NNP cord-005453-4057qib7 3213 29 1 1 CD cord-005453-4057qib7 3213 30 , , , cord-005453-4057qib7 3213 31 Radovan Radovan NNP cord-005453-4057qib7 3213 32 Vrhovac Vrhovac NNP cord-005453-4057qib7 3213 33 1 1 CD cord-005453-4057qib7 3213 34 1 1 CD cord-005453-4057qib7 3213 35 University University NNP cord-005453-4057qib7 3213 36 Hospital Hospital NNP cord-005453-4057qib7 3213 37 Centre Centre NNP cord-005453-4057qib7 3213 38 Zagreb Zagreb NNP cord-005453-4057qib7 3213 39 , , , cord-005453-4057qib7 3213 40 Zagreb Zagreb NNP cord-005453-4057qib7 3213 41 , , , cord-005453-4057qib7 3213 42 Croatia Croatia NNP cord-005453-4057qib7 3213 43 Background Background NNP cord-005453-4057qib7 3213 44 : : : cord-005453-4057qib7 3214 1 Endothelial endothelial JJ cord-005453-4057qib7 3214 2 dysfunction dysfunction NN cord-005453-4057qib7 3214 3 is be VBZ cord-005453-4057qib7 3214 4 a a DT cord-005453-4057qib7 3214 5 common common JJ cord-005453-4057qib7 3214 6 pathophysiology pathophysiology NN cord-005453-4057qib7 3214 7 of of IN cord-005453-4057qib7 3214 8 major major JJ cord-005453-4057qib7 3214 9 complications complication NNS cord-005453-4057qib7 3214 10 after after IN cord-005453-4057qib7 3214 11 allo allo NN cord-005453-4057qib7 3214 12 - - HYPH cord-005453-4057qib7 3214 13 SCT SCT NNP cord-005453-4057qib7 3214 14 , , , cord-005453-4057qib7 3214 15 such such JJ cord-005453-4057qib7 3214 16 as as IN cord-005453-4057qib7 3214 17 graft graft NN cord-005453-4057qib7 3214 18 - - HYPH cord-005453-4057qib7 3214 19 versus versus IN cord-005453-4057qib7 3214 20 - - HYPH cord-005453-4057qib7 3214 21 host host NN cord-005453-4057qib7 3214 22 disease disease NN cord-005453-4057qib7 3214 23 , , , cord-005453-4057qib7 3214 24 veno veno NNP cord-005453-4057qib7 3214 25 - - HYPH cord-005453-4057qib7 3214 26 occlusive occlusive JJ cord-005453-4057qib7 3214 27 disease disease NN cord-005453-4057qib7 3214 28 , , , cord-005453-4057qib7 3214 29 thrombotic thrombotic JJ cord-005453-4057qib7 3214 30 microangiopathy microangiopathy NN cord-005453-4057qib7 3214 31 and and CC cord-005453-4057qib7 3214 32 sepsis sepsis NN cord-005453-4057qib7 3214 33 . . . cord-005453-4057qib7 3215 1 Endothelial Endothelial NNP cord-005453-4057qib7 3215 2 Activation Activation NNP cord-005453-4057qib7 3215 3 and and CC cord-005453-4057qib7 3215 4 Stress Stress NNP cord-005453-4057qib7 3215 5 Index Index NNP cord-005453-4057qib7 3215 6 ( ( -LRB- cord-005453-4057qib7 3215 7 EASIX EASIX NNP cord-005453-4057qib7 3215 8 ) ) -RRB- cord-005453-4057qib7 3215 9 is be VBZ cord-005453-4057qib7 3215 10 a a DT cord-005453-4057qib7 3215 11 simple simple JJ cord-005453-4057qib7 3215 12 score score NN cord-005453-4057qib7 3215 13 comprised comprise VBN cord-005453-4057qib7 3215 14 of of IN cord-005453-4057qib7 3215 15 standard standard JJ cord-005453-4057qib7 3215 16 laboratory laboratory NN cord-005453-4057qib7 3215 17 parameters parameter NNS cord-005453-4057qib7 3215 18 ( ( -LRB- cord-005453-4057qib7 3215 19 creatinine creatinine NN cord-005453-4057qib7 3215 20 , , , cord-005453-4057qib7 3215 21 LDH LDH NNP cord-005453-4057qib7 3215 22 and and CC cord-005453-4057qib7 3215 23 thrombocytes thrombocytes NNP cord-005453-4057qib7 3215 24 ) ) -RRB- cord-005453-4057qib7 3215 25 developed develop VBD cord-005453-4057qib7 3215 26 as as IN cord-005453-4057qib7 3215 27 a a DT cord-005453-4057qib7 3215 28 potential potential JJ cord-005453-4057qib7 3215 29 tool tool NN cord-005453-4057qib7 3215 30 to to TO cord-005453-4057qib7 3215 31 predict predict VB cord-005453-4057qib7 3215 32 allo allo NNP cord-005453-4057qib7 3215 33 - - HYPH cord-005453-4057qib7 3215 34 SCT SCT NNP cord-005453-4057qib7 3215 35 mortality mortality NN cord-005453-4057qib7 3215 36 by by IN cord-005453-4057qib7 3215 37 Luft Luft NNP cord-005453-4057qib7 3215 38 and and CC cord-005453-4057qib7 3215 39 colleagues colleague NNS cord-005453-4057qib7 3215 40 . . . cord-005453-4057qib7 3216 1 A a DT cord-005453-4057qib7 3216 2 recent recent JJ cord-005453-4057qib7 3216 3 validation validation NN cord-005453-4057qib7 3216 4 of of IN cord-005453-4057qib7 3216 5 EASIX EASIX NNP cord-005453-4057qib7 3216 6 included include VBD cord-005453-4057qib7 3216 7 three three CD cord-005453-4057qib7 3216 8 retrospective retrospective JJ cord-005453-4057qib7 3216 9 cohorts cohort NNS cord-005453-4057qib7 3216 10 and and CC cord-005453-4057qib7 3216 11 showed show VBD cord-005453-4057qib7 3216 12 that that IN cord-005453-4057qib7 3216 13 EASIX EASIX NNP cord-005453-4057qib7 3216 14 taken take VBN cord-005453-4057qib7 3216 15 before before IN cord-005453-4057qib7 3216 16 start start NN cord-005453-4057qib7 3216 17 of of IN cord-005453-4057qib7 3216 18 conditioning conditioning NN cord-005453-4057qib7 3216 19 can can MD cord-005453-4057qib7 3216 20 be be VB cord-005453-4057qib7 3216 21 used use VBN cord-005453-4057qib7 3216 22 as as IN cord-005453-4057qib7 3216 23 an an DT cord-005453-4057qib7 3216 24 independent independent JJ cord-005453-4057qib7 3216 25 predictor predictor NN cord-005453-4057qib7 3216 26 of of IN cord-005453-4057qib7 3216 27 survival survival NN cord-005453-4057qib7 3216 28 after after IN cord-005453-4057qib7 3216 29 allo allo NN cord-005453-4057qib7 3216 30 - - HYPH cord-005453-4057qib7 3216 31 SCT SCT NNP cord-005453-4057qib7 3216 32 . . . cord-005453-4057qib7 3217 1 Methods method NNS cord-005453-4057qib7 3217 2 : : : cord-005453-4057qib7 3218 1 The the DT cord-005453-4057qib7 3218 2 aim aim NN cord-005453-4057qib7 3218 3 of of IN cord-005453-4057qib7 3218 4 our -PRON- PRP$ cord-005453-4057qib7 3218 5 study study NN cord-005453-4057qib7 3218 6 was be VBD cord-005453-4057qib7 3218 7 to to TO cord-005453-4057qib7 3218 8 retrospectively retrospectively RB cord-005453-4057qib7 3218 9 evaluate evaluate VB cord-005453-4057qib7 3218 10 pre pre JJ cord-005453-4057qib7 3218 11 - - JJ cord-005453-4057qib7 3218 12 transplant transplant JJ cord-005453-4057qib7 3218 13 EASIX EASIX NNP cord-005453-4057qib7 3218 14 in in IN cord-005453-4057qib7 3218 15 our -PRON- PRP$ cord-005453-4057qib7 3218 16 cohort cohort NN cord-005453-4057qib7 3218 17 of of IN cord-005453-4057qib7 3218 18 consecutive consecutive JJ cord-005453-4057qib7 3218 19 patients patient NNS cord-005453-4057qib7 3218 20 who who WP cord-005453-4057qib7 3218 21 underwent undergo VBD cord-005453-4057qib7 3218 22 allo allo NN cord-005453-4057qib7 3218 23 - - HYPH cord-005453-4057qib7 3218 24 SCT SCT NNP cord-005453-4057qib7 3218 25 in in IN cord-005453-4057qib7 3218 26 the the DT cord-005453-4057qib7 3218 27 University University NNP cord-005453-4057qib7 3218 28 Hospital Hospital NNP cord-005453-4057qib7 3218 29 Centre Centre NNP cord-005453-4057qib7 3218 30 Zagreb Zagreb NNP cord-005453-4057qib7 3218 31 between between IN cord-005453-4057qib7 3218 32 2012 2012 CD cord-005453-4057qib7 3218 33 and and CC cord-005453-4057qib7 3218 34 2017 2017 CD cord-005453-4057qib7 3218 35 . . . cord-005453-4057qib7 3219 1 With with IN cord-005453-4057qib7 3219 2 the the DT cord-005453-4057qib7 3219 3 use use NN cord-005453-4057qib7 3219 4 of of IN cord-005453-4057qib7 3219 5 a a DT cord-005453-4057qib7 3219 6 cut cut VBN cord-005453-4057qib7 3219 7 - - HYPH cord-005453-4057qib7 3219 8 off off NN cord-005453-4057qib7 3219 9 used use VBN cord-005453-4057qib7 3219 10 in in IN cord-005453-4057qib7 3219 11 the the DT cord-005453-4057qib7 3219 12 validation validation NN cord-005453-4057qib7 3219 13 cohorts cohort NNS cord-005453-4057qib7 3219 14 , , , cord-005453-4057qib7 3219 15 we -PRON- PRP cord-005453-4057qib7 3219 16 compared compare VBD cord-005453-4057qib7 3219 17 two two CD cord-005453-4057qib7 3219 18 groups group NNS cord-005453-4057qib7 3219 19 of of IN cord-005453-4057qib7 3219 20 patients patient NNS cord-005453-4057qib7 3219 21 for for IN cord-005453-4057qib7 3219 22 overall overall JJ cord-005453-4057qib7 3219 23 survival survival NN cord-005453-4057qib7 3219 24 ( ( -LRB- cord-005453-4057qib7 3219 25 OS OS NNP cord-005453-4057qib7 3219 26 ) ) -RRB- cord-005453-4057qib7 3219 27 and and CC cord-005453-4057qib7 3219 28 transplantrelated transplantrelate VBN cord-005453-4057qib7 3219 29 mortality mortality NN cord-005453-4057qib7 3219 30 ( ( -LRB- cord-005453-4057qib7 3219 31 TRM TRM NNP cord-005453-4057qib7 3219 32 ) ) -RRB- cord-005453-4057qib7 3219 33 . . . cord-005453-4057qib7 3220 1 Group group NN cord-005453-4057qib7 3220 2 comparisons comparison NNS cord-005453-4057qib7 3220 3 were be VBD cord-005453-4057qib7 3220 4 done do VBN cord-005453-4057qib7 3220 5 using use VBG cord-005453-4057qib7 3220 6 the the DT cord-005453-4057qib7 3220 7 log log NN cord-005453-4057qib7 3220 8 - - HYPH cord-005453-4057qib7 3220 9 rank rank NN cord-005453-4057qib7 3220 10 test test NN cord-005453-4057qib7 3220 11 or or CC cord-005453-4057qib7 3220 12 Gray gray JJ cord-005453-4057qib7 3220 13 test test NN cord-005453-4057qib7 3220 14 for for IN cord-005453-4057qib7 3220 15 competing compete VBG cord-005453-4057qib7 3220 16 risks risk NNS cord-005453-4057qib7 3220 17 outcomes outcome NNS cord-005453-4057qib7 3220 18 . . . cord-005453-4057qib7 3221 1 A a DT cord-005453-4057qib7 3221 2 multivariate multivariate JJ cord-005453-4057qib7 3221 3 analysis analysis NN cord-005453-4057qib7 3221 4 evaluated evaluate VBD cord-005453-4057qib7 3221 5 the the DT cord-005453-4057qib7 3221 6 association association NN cord-005453-4057qib7 3221 7 of of IN cord-005453-4057qib7 3221 8 OS OS NNP cord-005453-4057qib7 3221 9 with with IN cord-005453-4057qib7 3221 10 relevant relevant JJ cord-005453-4057qib7 3221 11 variables variable NNS cord-005453-4057qib7 3221 12 by by IN cord-005453-4057qib7 3221 13 using use VBG cord-005453-4057qib7 3221 14 a a DT cord-005453-4057qib7 3221 15 Cox Cox NNP cord-005453-4057qib7 3221 16 's 's POS cord-005453-4057qib7 3221 17 proportionalhazard proportionalhazard JJ cord-005453-4057qib7 3221 18 regression regression NN cord-005453-4057qib7 3221 19 model model NN cord-005453-4057qib7 3221 20 . . . cord-005453-4057qib7 3222 1 Results result NNS cord-005453-4057qib7 3222 2 : : : cord-005453-4057qib7 3223 1 Our -PRON- PRP$ cord-005453-4057qib7 3223 2 study study NN cord-005453-4057qib7 3223 3 group group NN cord-005453-4057qib7 3223 4 included include VBD cord-005453-4057qib7 3223 5 313 313 CD cord-005453-4057qib7 3223 6 patients patient NNS cord-005453-4057qib7 3223 7 and and CC cord-005453-4057qib7 3223 8 comprised comprise VBD cord-005453-4057qib7 3223 9 180 180 CD cord-005453-4057qib7 3223 10 males male NNS cord-005453-4057qib7 3223 11 ( ( -LRB- cord-005453-4057qib7 3223 12 57 57 CD cord-005453-4057qib7 3223 13 % % NN cord-005453-4057qib7 3223 14 ) ) -RRB- cord-005453-4057qib7 3223 15 and and CC cord-005453-4057qib7 3223 16 133 133 CD cord-005453-4057qib7 3223 17 females female NNS cord-005453-4057qib7 3223 18 ( ( -LRB- cord-005453-4057qib7 3223 19 43 43 CD cord-005453-4057qib7 3223 20 % % NN cord-005453-4057qib7 3223 21 , , , cord-005453-4057qib7 3223 22 with with IN cord-005453-4057qib7 3223 23 a a DT cord-005453-4057qib7 3223 24 median median JJ cord-005453-4057qib7 3223 25 age age NN cord-005453-4057qib7 3223 26 of of IN cord-005453-4057qib7 3223 27 48 48 CD cord-005453-4057qib7 3223 28 years year NNS cord-005453-4057qib7 3223 29 ( ( -LRB- cord-005453-4057qib7 3223 30 range range NN cord-005453-4057qib7 3223 31 , , , cord-005453-4057qib7 3223 32 18 18 CD cord-005453-4057qib7 3223 33 to to TO cord-005453-4057qib7 3223 34 67 67 CD cord-005453-4057qib7 3223 35 years year NNS cord-005453-4057qib7 3223 36 ) ) -RRB- cord-005453-4057qib7 3223 37 at at IN cord-005453-4057qib7 3223 38 the the DT cord-005453-4057qib7 3223 39 time time NN cord-005453-4057qib7 3223 40 of of IN cord-005453-4057qib7 3223 41 transplantation transplantation NN cord-005453-4057qib7 3223 42 . . . cord-005453-4057qib7 3224 1 The the DT cord-005453-4057qib7 3224 2 most most RBS cord-005453-4057qib7 3224 3 frequent frequent JJ cord-005453-4057qib7 3224 4 malignancies malignancy NNS cord-005453-4057qib7 3224 5 in in IN cord-005453-4057qib7 3224 6 our -PRON- PRP$ cord-005453-4057qib7 3224 7 population population NN cord-005453-4057qib7 3224 8 were be VBD cord-005453-4057qib7 3224 9 acute acute JJ cord-005453-4057qib7 3224 10 leukemia leukemia NN cord-005453-4057qib7 3224 11 ( ( -LRB- cord-005453-4057qib7 3224 12 196 196 CD cord-005453-4057qib7 3224 13 patients patient NNS cord-005453-4057qib7 3224 14 , , , cord-005453-4057qib7 3224 15 63 63 CD cord-005453-4057qib7 3224 16 % % NN cord-005453-4057qib7 3224 17 ) ) -RRB- cord-005453-4057qib7 3224 18 and and CC cord-005453-4057qib7 3224 19 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 3224 20 / / SYM cord-005453-4057qib7 3224 21 myeloproliferative myeloproliferative JJ cord-005453-4057qib7 3224 22 neoplasm neoplasm NN cord-005453-4057qib7 3224 23 ( ( -LRB- cord-005453-4057qib7 3224 24 451 451 CD cord-005453-4057qib7 3224 25 patients patient NNS cord-005453-4057qib7 3224 26 ; ; : cord-005453-4057qib7 3224 27 16 16 CD cord-005453-4057qib7 3224 28 % % NN cord-005453-4057qib7 3224 29 ) ) -RRB- cord-005453-4057qib7 3224 30 . . . cord-005453-4057qib7 3225 1 The the DT cord-005453-4057qib7 3225 2 donor donor NN cord-005453-4057qib7 3225 3 was be VBD cord-005453-4057qib7 3225 4 an an DT cord-005453-4057qib7 3225 5 identical identical JJ cord-005453-4057qib7 3225 6 sibling sibling NN cord-005453-4057qib7 3225 7 for for IN cord-005453-4057qib7 3225 8 106 106 CD cord-005453-4057qib7 3225 9 patients patient NNS cord-005453-4057qib7 3225 10 ( ( -LRB- cord-005453-4057qib7 3225 11 34 34 CD cord-005453-4057qib7 3225 12 % % NN cord-005453-4057qib7 3225 13 ) ) -RRB- cord-005453-4057qib7 3225 14 , , , cord-005453-4057qib7 3225 15 matched match VBD cord-005453-4057qib7 3225 16 unrelated unrelated JJ cord-005453-4057qib7 3225 17 donor donor NN cord-005453-4057qib7 3225 18 for for IN cord-005453-4057qib7 3225 19 176 176 CD cord-005453-4057qib7 3225 20 patients patient NNS cord-005453-4057qib7 3225 21 ( ( -LRB- cord-005453-4057qib7 3225 22 56 56 CD cord-005453-4057qib7 3225 23 % % NN cord-005453-4057qib7 3225 24 ) ) -RRB- cord-005453-4057qib7 3225 25 and and CC cord-005453-4057qib7 3225 26 haploidentical haploidentical JJ cord-005453-4057qib7 3225 27 for for IN cord-005453-4057qib7 3225 28 31 31 CD cord-005453-4057qib7 3225 29 patients patient NNS cord-005453-4057qib7 3225 30 ( ( -LRB- cord-005453-4057qib7 3225 31 10 10 CD cord-005453-4057qib7 3225 32 % % NN cord-005453-4057qib7 3225 33 ) ) -RRB- cord-005453-4057qib7 3225 34 . . . cord-005453-4057qib7 3226 1 104 104 CD cord-005453-4057qib7 3226 2 patients patient NNS cord-005453-4057qib7 3226 3 ( ( -LRB- cord-005453-4057qib7 3226 4 33 33 CD cord-005453-4057qib7 3226 5 % % NN cord-005453-4057qib7 3226 6 ) ) -RRB- cord-005453-4057qib7 3226 7 received receive VBD cord-005453-4057qib7 3226 8 a a DT cord-005453-4057qib7 3226 9 myeloablative myeloablative JJ cord-005453-4057qib7 3226 10 conditioning conditioning NN cord-005453-4057qib7 3226 11 regimen regimen NN cord-005453-4057qib7 3226 12 while while IN cord-005453-4057qib7 3226 13 209 209 CD cord-005453-4057qib7 3226 14 patients patient NNS cord-005453-4057qib7 3226 15 ( ( -LRB- cord-005453-4057qib7 3226 16 67 67 CD cord-005453-4057qib7 3226 17 % % NN cord-005453-4057qib7 3226 18 ) ) -RRB- cord-005453-4057qib7 3226 19 received receive VBD cord-005453-4057qib7 3226 20 a a DT cord-005453-4057qib7 3226 21 reduced reduce VBN cord-005453-4057qib7 3226 22 - - HYPH cord-005453-4057qib7 3226 23 intensity intensity NN cord-005453-4057qib7 3226 24 conditioning conditioning NN cord-005453-4057qib7 3226 25 regimen regimen NN cord-005453-4057qib7 3226 26 . . . cord-005453-4057qib7 3227 1 With with IN cord-005453-4057qib7 3227 2 a a DT cord-005453-4057qib7 3227 3 median median JJ cord-005453-4057qib7 3227 4 follow follow NN cord-005453-4057qib7 3227 5 - - HYPH cord-005453-4057qib7 3227 6 up up NN cord-005453-4057qib7 3227 7 of of IN cord-005453-4057qib7 3227 8 16 16 CD cord-005453-4057qib7 3227 9 months month NNS cord-005453-4057qib7 3227 10 ( ( -LRB- cord-005453-4057qib7 3227 11 range range NN cord-005453-4057qib7 3227 12 , , , cord-005453-4057qib7 3227 13 12 12 CD cord-005453-4057qib7 3227 14 - - SYM cord-005453-4057qib7 3227 15 60 60 CD cord-005453-4057qib7 3227 16 ) ) -RRB- cord-005453-4057qib7 3227 17 for for IN cord-005453-4057qib7 3227 18 the the DT cord-005453-4057qib7 3227 19 whole whole JJ cord-005453-4057qib7 3227 20 study study NN cord-005453-4057qib7 3227 21 group group NN cord-005453-4057qib7 3227 22 , , , cord-005453-4057qib7 3227 23 the the DT cord-005453-4057qib7 3227 24 OS OS NNP cord-005453-4057qib7 3227 25 at at IN cord-005453-4057qib7 3227 26 24 24 CD cord-005453-4057qib7 3227 27 months month NNS cord-005453-4057qib7 3227 28 was be VBD cord-005453-4057qib7 3227 29 60 60 CD cord-005453-4057qib7 3227 30 % % NN cord-005453-4057qib7 3227 31 , , , cord-005453-4057qib7 3227 32 ( ( -LRB- cord-005453-4057qib7 3227 33 95%CI 95%ci CD cord-005453-4057qib7 3227 34 54 54 CD cord-005453-4057qib7 3227 35 - - SYM cord-005453-4057qib7 3227 36 68 68 CD cord-005453-4057qib7 3227 37 ) ) -RRB- cord-005453-4057qib7 3227 38 in in IN cord-005453-4057qib7 3227 39 the the DT cord-005453-4057qib7 3227 40 group group NN cord-005453-4057qib7 3227 41 of of IN cord-005453-4057qib7 3227 42 patients patient NNS cord-005453-4057qib7 3227 43 with with IN cord-005453-4057qib7 3227 44 low low JJ cord-005453-4057qib7 3227 45 EASIX EASIX NNP cord-005453-4057qib7 3227 46 score score NN cord-005453-4057qib7 3227 47 and and CC cord-005453-4057qib7 3227 48 43 43 CD cord-005453-4057qib7 3227 49 % % NN cord-005453-4057qib7 3227 50 ( ( -LRB- cord-005453-4057qib7 3227 51 95 95 CD cord-005453-4057qib7 3227 52 % % NN cord-005453-4057qib7 3227 53 CI CI NNP cord-005453-4057qib7 3227 54 33 33 CD cord-005453-4057qib7 3227 55 - - SYM cord-005453-4057qib7 3227 56 56 56 CD cord-005453-4057qib7 3227 57 ) ) -RRB- cord-005453-4057qib7 3227 58 in in IN cord-005453-4057qib7 3227 59 the the DT cord-005453-4057qib7 3227 60 group group NN cord-005453-4057qib7 3227 61 of of IN cord-005453-4057qib7 3227 62 patients patient NNS cord-005453-4057qib7 3227 63 with with IN cord-005453-4057qib7 3227 64 high high JJ cord-005453-4057qib7 3227 65 EASIX EASIX NNP cord-005453-4057qib7 3227 66 score score NN cord-005453-4057qib7 3227 67 ( ( -LRB- cord-005453-4057qib7 3227 68 p=0.004 p=0.004 NNP cord-005453-4057qib7 3227 69 ) ) -RRB- cord-005453-4057qib7 3227 70 . . . cord-005453-4057qib7 3228 1 This this DT cord-005453-4057qib7 3228 2 difference difference NN cord-005453-4057qib7 3228 3 was be VBD cord-005453-4057qib7 3228 4 mainly mainly RB cord-005453-4057qib7 3228 5 attributed attribute VBN cord-005453-4057qib7 3228 6 to to IN cord-005453-4057qib7 3228 7 higher high JJR cord-005453-4057qib7 3228 8 TRM TRM NNP cord-005453-4057qib7 3228 9 in in IN cord-005453-4057qib7 3228 10 the the DT cord-005453-4057qib7 3228 11 group group NN cord-005453-4057qib7 3228 12 with with IN cord-005453-4057qib7 3228 13 high high JJ cord-005453-4057qib7 3228 14 EASIX EASIX NNP cord-005453-4057qib7 3228 15 score score NN cord-005453-4057qib7 3228 16 ( ( -LRB- cord-005453-4057qib7 3228 17 32 32 CD cord-005453-4057qib7 3228 18 % % NN cord-005453-4057qib7 3228 19 , , , cord-005453-4057qib7 3228 20 95%CI 95%ci CD cord-005453-4057qib7 3228 21 22 22 CD cord-005453-4057qib7 3228 22 - - SYM cord-005453-4057qib7 3228 23 45 45 CD cord-005453-4057qib7 3228 24 at at IN cord-005453-4057qib7 3228 25 12 12 CD cord-005453-4057qib7 3228 26 months month NNS cord-005453-4057qib7 3228 27 ) ) -RRB- cord-005453-4057qib7 3228 28 compared compare VBN cord-005453-4057qib7 3228 29 to to IN cord-005453-4057qib7 3228 30 the the DT cord-005453-4057qib7 3228 31 group group NN cord-005453-4057qib7 3228 32 with with IN cord-005453-4057qib7 3228 33 low low JJ cord-005453-4057qib7 3228 34 EASIX EASIX NNP cord-005453-4057qib7 3228 35 score score NN cord-005453-4057qib7 3228 36 ( ( -LRB- cord-005453-4057qib7 3228 37 18 18 CD cord-005453-4057qib7 3228 38 % % NN cord-005453-4057qib7 3228 39 , , , cord-005453-4057qib7 3228 40 95%CI 95%ci CD cord-005453-4057qib7 3228 41 13 13 CD cord-005453-4057qib7 3228 42 - - SYM cord-005453-4057qib7 3228 43 23 23 CD cord-005453-4057qib7 3228 44 at at IN cord-005453-4057qib7 3228 45 12 12 CD cord-005453-4057qib7 3228 46 months month NNS cord-005453-4057qib7 3228 47 ) ) -RRB- cord-005453-4057qib7 3228 48 ( ( -LRB- cord-005453-4057qib7 3228 49 p=0.009 p=0.009 NN cord-005453-4057qib7 3228 50 ) ) -RRB- cord-005453-4057qib7 3228 51 . . . cord-005453-4057qib7 3229 1 In in IN cord-005453-4057qib7 3229 2 the the DT cord-005453-4057qib7 3229 3 multivariate multivariate JJ cord-005453-4057qib7 3229 4 analysis analysis NN cord-005453-4057qib7 3229 5 which which WDT cord-005453-4057qib7 3229 6 included include VBD cord-005453-4057qib7 3229 7 EASIX EASIX NNP cord-005453-4057qib7 3229 8 , , , cord-005453-4057qib7 3229 9 patients patient NNS cord-005453-4057qib7 3229 10 ' ' POS cord-005453-4057qib7 3229 11 age age NN cord-005453-4057qib7 3229 12 , , , cord-005453-4057qib7 3229 13 intensity intensity NN cord-005453-4057qib7 3229 14 of of IN cord-005453-4057qib7 3229 15 conditioning conditioning NN cord-005453-4057qib7 3229 16 , , , cord-005453-4057qib7 3229 17 diagnosis diagnosis NN cord-005453-4057qib7 3229 18 ( ( -LRB- cord-005453-4057qib7 3229 19 lymphoid lymphoid NN cord-005453-4057qib7 3229 20 vs vs IN cord-005453-4057qib7 3229 21 myeloid myeloid NN cord-005453-4057qib7 3229 22 ) ) -RRB- cord-005453-4057qib7 3229 23 , , , cord-005453-4057qib7 3229 24 status status NN cord-005453-4057qib7 3229 25 of of IN cord-005453-4057qib7 3229 26 the the DT cord-005453-4057qib7 3229 27 disease disease NN cord-005453-4057qib7 3229 28 at at IN cord-005453-4057qib7 3229 29 transplant transplant NN cord-005453-4057qib7 3229 30 and and CC cord-005453-4057qib7 3229 31 type type NN cord-005453-4057qib7 3229 32 of of IN cord-005453-4057qib7 3229 33 the the DT cord-005453-4057qib7 3229 34 donor donor NN cord-005453-4057qib7 3229 35 , , , cord-005453-4057qib7 3229 36 worse bad JJR cord-005453-4057qib7 3229 37 OS OS NNP cord-005453-4057qib7 3229 38 was be VBD cord-005453-4057qib7 3229 39 independently independently RB cord-005453-4057qib7 3229 40 associated associate VBN cord-005453-4057qib7 3229 41 only only RB cord-005453-4057qib7 3229 42 with with IN cord-005453-4057qib7 3229 43 older old JJR cord-005453-4057qib7 3229 44 age age NN cord-005453-4057qib7 3229 45 of of IN cord-005453-4057qib7 3229 46 patients patient NNS cord-005453-4057qib7 3229 47 ( ( -LRB- cord-005453-4057qib7 3229 48 HR HR NNP cord-005453-4057qib7 3229 49 1.66 1.66 CD cord-005453-4057qib7 3229 50 ; ; : cord-005453-4057qib7 3229 51 95 95 CD cord-005453-4057qib7 3229 52 % % NN cord-005453-4057qib7 3229 53 CI ci NN cord-005453-4057qib7 3229 54 , , , cord-005453-4057qib7 3229 55 1.07 1.07 CD cord-005453-4057qib7 3229 56 - - SYM cord-005453-4057qib7 3229 57 2.59 2.59 CD cord-005453-4057qib7 3229 58 , , , cord-005453-4057qib7 3229 59 p=0.02 p=0.02 NN cord-005453-4057qib7 3229 60 ) ) -RRB- cord-005453-4057qib7 3229 61 and and CC cord-005453-4057qib7 3229 62 high high JJ cord-005453-4057qib7 3229 63 EASIX EASIX NNP cord-005453-4057qib7 3229 64 score score NN cord-005453-4057qib7 3229 65 ( ( -LRB- cord-005453-4057qib7 3229 66 HR HR NNP cord-005453-4057qib7 3229 67 1.51 1.51 CD cord-005453-4057qib7 3229 68 ; ; : cord-005453-4057qib7 3229 69 95 95 CD cord-005453-4057qib7 3229 70 % % NN cord-005453-4057qib7 3229 71 CI CI NNP cord-005453-4057qib7 3229 72 , , , cord-005453-4057qib7 3229 73 1.01 1.01 CD cord-005453-4057qib7 3229 74 - - SYM cord-005453-4057qib7 3229 75 2.24 2.24 CD cord-005453-4057qib7 3229 76 , , , cord-005453-4057qib7 3229 77 p=0.04 p=0.04 NNP cord-005453-4057qib7 3229 78 ) ) -RRB- cord-005453-4057qib7 3229 79 . . . cord-005453-4057qib7 3230 1 Conclusions conclusion NNS cord-005453-4057qib7 3230 2 : : : cord-005453-4057qib7 3231 1 Our -PRON- PRP$ cord-005453-4057qib7 3231 2 retrospective retrospective JJ cord-005453-4057qib7 3231 3 data datum NNS cord-005453-4057qib7 3231 4 support support VBP cord-005453-4057qib7 3231 5 previous previous JJ cord-005453-4057qib7 3231 6 data datum NNS cord-005453-4057qib7 3231 7 and and CC cord-005453-4057qib7 3231 8 suggest suggest VBP cord-005453-4057qib7 3231 9 that that IN cord-005453-4057qib7 3231 10 EASIX EASIX NNP cord-005453-4057qib7 3231 11 could could MD cord-005453-4057qib7 3231 12 potentially potentially RB cord-005453-4057qib7 3231 13 serve serve VB cord-005453-4057qib7 3231 14 as as IN cord-005453-4057qib7 3231 15 a a DT cord-005453-4057qib7 3231 16 valid valid JJ cord-005453-4057qib7 3231 17 tool tool NN cord-005453-4057qib7 3231 18 for for IN cord-005453-4057qib7 3231 19 prediction prediction NN cord-005453-4057qib7 3231 20 of of IN cord-005453-4057qib7 3231 21 allo allo NNP cord-005453-4057qib7 3231 22 - - HYPH cord-005453-4057qib7 3231 23 SCT SCT NNP cord-005453-4057qib7 3231 24 outcomes outcome NNS cord-005453-4057qib7 3231 25 . . . cord-005453-4057qib7 3232 1 As as IN cord-005453-4057qib7 3232 2 a a DT cord-005453-4057qib7 3232 3 simple simple JJ cord-005453-4057qib7 3232 4 biomarker biomarker NN cord-005453-4057qib7 3232 5 panel panel NN cord-005453-4057qib7 3232 6 , , , cord-005453-4057qib7 3232 7 EASIX EASIX NNP cord-005453-4057qib7 3232 8 could could MD cord-005453-4057qib7 3232 9 easily easily RB cord-005453-4057qib7 3232 10 be be VB cord-005453-4057qib7 3232 11 implemented implement VBN cord-005453-4057qib7 3232 12 in in IN cord-005453-4057qib7 3232 13 clinical clinical JJ cord-005453-4057qib7 3232 14 decision decision NN cord-005453-4057qib7 3232 15 making make VBG cord-005453-4057qib7 3232 16 in in IN cord-005453-4057qib7 3232 17 the the DT cord-005453-4057qib7 3232 18 field field NN cord-005453-4057qib7 3232 19 of of IN cord-005453-4057qib7 3232 20 allo allo NN cord-005453-4057qib7 3232 21 - - HYPH cord-005453-4057qib7 3232 22 SCT SCT NNP cord-005453-4057qib7 3232 23 . . . cord-005453-4057qib7 3233 1 These these DT cord-005453-4057qib7 3233 2 retrospective retrospective JJ cord-005453-4057qib7 3233 3 data datum NNS cord-005453-4057qib7 3233 4 need need VBP cord-005453-4057qib7 3233 5 validation validation NN cord-005453-4057qib7 3233 6 in in IN cord-005453-4057qib7 3233 7 a a DT cord-005453-4057qib7 3233 8 prospective prospective JJ cord-005453-4057qib7 3233 9 study study NN cord-005453-4057qib7 3233 10 which which WDT cord-005453-4057qib7 3233 11 is be VBZ cord-005453-4057qib7 3233 12 currently currently RB cord-005453-4057qib7 3233 13 being be VBG cord-005453-4057qib7 3233 14 conducted conduct VBN cord-005453-4057qib7 3233 15 . . . cord-005453-4057qib7 3234 1 Clinical clinical JJ cord-005453-4057qib7 3234 2 Background background NN cord-005453-4057qib7 3234 3 : : : cord-005453-4057qib7 3234 4 Veno Veno NNP cord-005453-4057qib7 3234 5 - - HYPH cord-005453-4057qib7 3234 6 occlusive occlusive JJ cord-005453-4057qib7 3234 7 disease disease NN cord-005453-4057qib7 3235 1 ( ( -LRB- cord-005453-4057qib7 3235 2 VOD VOD NNP cord-005453-4057qib7 3235 3 ) ) -RRB- cord-005453-4057qib7 3235 4 is be VBZ cord-005453-4057qib7 3235 5 a a DT cord-005453-4057qib7 3235 6 potentially potentially RB cord-005453-4057qib7 3235 7 devastating devastating JJ cord-005453-4057qib7 3235 8 complication complication NN cord-005453-4057qib7 3235 9 that that WDT cord-005453-4057qib7 3235 10 can can MD cord-005453-4057qib7 3235 11 occur occur VB cord-005453-4057qib7 3235 12 after after IN cord-005453-4057qib7 3235 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 3235 14 stem stem NN cord-005453-4057qib7 3235 15 cell cell NN cord-005453-4057qib7 3235 16 transplant transplant NN cord-005453-4057qib7 3235 17 ( ( -LRB- cord-005453-4057qib7 3235 18 HSCT HSCT NNP cord-005453-4057qib7 3235 19 ) ) -RRB- cord-005453-4057qib7 3235 20 and and CC cord-005453-4057qib7 3235 21 in in IN cord-005453-4057qib7 3235 22 severe severe JJ cord-005453-4057qib7 3235 23 cases case NNS cord-005453-4057qib7 3235 24 can can MD cord-005453-4057qib7 3235 25 lead lead VB cord-005453-4057qib7 3235 26 to to IN cord-005453-4057qib7 3235 27 multi multi JJ cord-005453-4057qib7 3235 28 - - JJ cord-005453-4057qib7 3235 29 organ organ JJ cord-005453-4057qib7 3235 30 failure failure NN cord-005453-4057qib7 3235 31 . . . cord-005453-4057qib7 3236 1 ( ( -LRB- cord-005453-4057qib7 3236 2 Mohty Mohty NNP cord-005453-4057qib7 3236 3 2016 2016 CD cord-005453-4057qib7 3236 4 ) ) -RRB- cord-005453-4057qib7 3236 5 Defibrotide Defibrotide NNP cord-005453-4057qib7 3236 6 has have VBZ cord-005453-4057qib7 3236 7 been be VBN cord-005453-4057qib7 3236 8 proven prove VBN cord-005453-4057qib7 3236 9 to to TO cord-005453-4057qib7 3236 10 be be VB cord-005453-4057qib7 3236 11 effective effective JJ cord-005453-4057qib7 3236 12 to to TO cord-005453-4057qib7 3236 13 prevent prevent VB cord-005453-4057qib7 3236 14 and and CC cord-005453-4057qib7 3236 15 treat treat VB cord-005453-4057qib7 3236 16 VOD VOD NNP cord-005453-4057qib7 3236 17 , , , cord-005453-4057qib7 3236 18 and and CC cord-005453-4057qib7 3236 19 it -PRON- PRP cord-005453-4057qib7 3236 20 is be VBZ cord-005453-4057qib7 3236 21 critical critical JJ cord-005453-4057qib7 3236 22 that that IN cord-005453-4057qib7 3236 23 clinicians clinician NNS cord-005453-4057qib7 3236 24 are be VBP cord-005453-4057qib7 3236 25 aware aware JJ cord-005453-4057qib7 3236 26 of of IN cord-005453-4057qib7 3236 27 how how WRB cord-005453-4057qib7 3236 28 to to TO cord-005453-4057qib7 3236 29 diagnose diagnose VB cord-005453-4057qib7 3236 30 and and CC cord-005453-4057qib7 3236 31 treat treat VB cord-005453-4057qib7 3236 32 this this DT cord-005453-4057qib7 3236 33 serious serious JJ cord-005453-4057qib7 3236 34 complication complication NN cord-005453-4057qib7 3236 35 of of IN cord-005453-4057qib7 3236 36 HSCT HSCT NNP cord-005453-4057qib7 3236 37 . . . cord-005453-4057qib7 3237 1 This this DT cord-005453-4057qib7 3237 2 study study NN cord-005453-4057qib7 3237 3 was be VBD cord-005453-4057qib7 3237 4 conducted conduct VBN cord-005453-4057qib7 3237 5 to to TO cord-005453-4057qib7 3237 6 determine determine VB cord-005453-4057qib7 3237 7 if if IN cord-005453-4057qib7 3237 8 an an DT cord-005453-4057qib7 3237 9 online online NN cord-005453-4057qib7 3237 10 , , , cord-005453-4057qib7 3237 11 simulation simulation NN cord-005453-4057qib7 3237 12 - - HYPH cord-005453-4057qib7 3237 13 based base VBN cord-005453-4057qib7 3237 14 continuing continue VBG cord-005453-4057qib7 3237 15 medical medical JJ cord-005453-4057qib7 3237 16 education education NN cord-005453-4057qib7 3237 17 ( ( -LRB- cord-005453-4057qib7 3237 18 CME CME NNP cord-005453-4057qib7 3237 19 ) ) -RRB- cord-005453-4057qib7 3237 20 intervention intervention NN cord-005453-4057qib7 3237 21 could could MD cord-005453-4057qib7 3237 22 improve improve VB cord-005453-4057qib7 3237 23 performance performance NN cord-005453-4057qib7 3237 24 of of IN cord-005453-4057qib7 3237 25 hematologists hematologist NNS cord-005453-4057qib7 3237 26 / / SYM cord-005453-4057qib7 3237 27 oncologists oncologist NNS cord-005453-4057qib7 3237 28 ( ( -LRB- cord-005453-4057qib7 3237 29 hem/ hem/ NNP cord-005453-4057qib7 3237 30 onc onc NNP cord-005453-4057qib7 3237 31 ) ) -RRB- cord-005453-4057qib7 3237 32 and and CC cord-005453-4057qib7 3237 33 advanced advanced JJ cord-005453-4057qib7 3237 34 practice practice NN cord-005453-4057qib7 3237 35 providers provider NNS cord-005453-4057qib7 3237 36 ( ( -LRB- cord-005453-4057qib7 3237 37 nurse nurse NN cord-005453-4057qib7 3237 38 practitioners practitioner NNS cord-005453-4057qib7 3237 39 and and CC cord-005453-4057qib7 3237 40 physician physician NN cord-005453-4057qib7 3237 41 assistants assistant NNS cord-005453-4057qib7 3237 42 , , , cord-005453-4057qib7 3237 43 APPs app NNS cord-005453-4057qib7 3237 44 ) ) -RRB- cord-005453-4057qib7 3237 45 in in IN cord-005453-4057qib7 3237 46 the the DT cord-005453-4057qib7 3237 47 diagnosis diagnosis NN cord-005453-4057qib7 3237 48 and and CC cord-005453-4057qib7 3237 49 treatment treatment NN cord-005453-4057qib7 3237 50 of of IN cord-005453-4057qib7 3237 51 patients patient NNS cord-005453-4057qib7 3237 52 with with IN cord-005453-4057qib7 3237 53 VOD VOD NNP cord-005453-4057qib7 3237 54 . . . cord-005453-4057qib7 3238 1 ( ( -LRB- cord-005453-4057qib7 3238 2 Methods method NNS cord-005453-4057qib7 3238 3 : : : cord-005453-4057qib7 3238 4 A a DT cord-005453-4057qib7 3238 5 CME CME NNP cord-005453-4057qib7 3238 6 certified certify VBN cord-005453-4057qib7 3238 7 virtual virtual JJ cord-005453-4057qib7 3238 8 patient patient NN cord-005453-4057qib7 3238 9 simulation simulation NN cord-005453-4057qib7 3238 10 ( ( -LRB- cord-005453-4057qib7 3238 11 VPS VPS NNP cord-005453-4057qib7 3238 12 ) ) -RRB- cord-005453-4057qib7 3238 13 was be VBD cord-005453-4057qib7 3238 14 made make VBN cord-005453-4057qib7 3238 15 available available JJ cord-005453-4057qib7 3238 16 via via IN cord-005453-4057qib7 3238 17 a a DT cord-005453-4057qib7 3238 18 website website NN cord-005453-4057qib7 3238 19 dedicated dedicate VBN cord-005453-4057qib7 3238 20 to to IN cord-005453-4057qib7 3238 21 continuous continuous JJ cord-005453-4057qib7 3238 22 professional professional JJ cord-005453-4057qib7 3238 23 development development NN cord-005453-4057qib7 3238 24 . . . cord-005453-4057qib7 3239 1 The the DT cord-005453-4057qib7 3239 2 VPS VPS NNP cord-005453-4057qib7 3239 3 consisted consist VBD cord-005453-4057qib7 3239 4 of of IN cord-005453-4057qib7 3239 5 2 2 CD cord-005453-4057qib7 3239 6 cases case NNS cord-005453-4057qib7 3239 7 presented present VBN cord-005453-4057qib7 3239 8 in in IN cord-005453-4057qib7 3239 9 a a DT cord-005453-4057qib7 3239 10 platform platform NN cord-005453-4057qib7 3239 11 that that WDT cord-005453-4057qib7 3239 12 allows allow VBZ cord-005453-4057qib7 3239 13 clinicians clinician NNS cord-005453-4057qib7 3239 14 to to TO cord-005453-4057qib7 3239 15 assess assess VB cord-005453-4057qib7 3239 16 the the DT cord-005453-4057qib7 3239 17 patients patient NNS cord-005453-4057qib7 3239 18 and and CC cord-005453-4057qib7 3239 19 make make VB cord-005453-4057qib7 3239 20 diagnostic diagnostic JJ cord-005453-4057qib7 3239 21 and and CC cord-005453-4057qib7 3239 22 therapeutic therapeutic JJ cord-005453-4057qib7 3239 23 decisions decision NNS cord-005453-4057qib7 3239 24 supported support VBN cord-005453-4057qib7 3239 25 by by IN cord-005453-4057qib7 3239 26 an an DT cord-005453-4057qib7 3239 27 extensive extensive JJ cord-005453-4057qib7 3239 28 database database NN cord-005453-4057qib7 3239 29 of of IN cord-005453-4057qib7 3239 30 diagnostic diagnostic JJ cord-005453-4057qib7 3239 31 and and CC cord-005453-4057qib7 3239 32 treatment treatment NN cord-005453-4057qib7 3239 33 possibilities possibility NNS cord-005453-4057qib7 3239 34 , , , cord-005453-4057qib7 3239 35 matching match VBG cord-005453-4057qib7 3239 36 the the DT cord-005453-4057qib7 3239 37 scope scope NN cord-005453-4057qib7 3239 38 and and CC cord-005453-4057qib7 3239 39 depth depth NN cord-005453-4057qib7 3239 40 of of IN cord-005453-4057qib7 3239 41 actual actual JJ cord-005453-4057qib7 3239 42 practice practice NN cord-005453-4057qib7 3239 43 . . . cord-005453-4057qib7 3240 1 Clinical clinical JJ cord-005453-4057qib7 3240 2 decisions decision NNS cord-005453-4057qib7 3240 3 were be VBD cord-005453-4057qib7 3240 4 analyzed analyze VBN cord-005453-4057qib7 3240 5 using use VBG cord-005453-4057qib7 3240 6 a a DT cord-005453-4057qib7 3240 7 sophisticated sophisticated JJ cord-005453-4057qib7 3240 8 decision decision NN cord-005453-4057qib7 3240 9 engine engine NN cord-005453-4057qib7 3240 10 , , , cord-005453-4057qib7 3240 11 and and CC cord-005453-4057qib7 3240 12 tailored tailor VBN cord-005453-4057qib7 3240 13 clinical clinical JJ cord-005453-4057qib7 3240 14 guidance guidance NN cord-005453-4057qib7 3240 15 ( ( -LRB- cord-005453-4057qib7 3240 16 CG CG NNP cord-005453-4057qib7 3240 17 ) ) -RRB- cord-005453-4057qib7 3240 18 employing employ VBG cord-005453-4057qib7 3241 1 up up IN cord-005453-4057qib7 3241 2 - - HYPH cord-005453-4057qib7 3241 3 to to IN cord-005453-4057qib7 3241 4 - - HYPH cord-005453-4057qib7 3241 5 date date NN cord-005453-4057qib7 3241 6 evidence evidence NN cord-005453-4057qib7 3241 7 - - HYPH cord-005453-4057qib7 3241 8 based base VBN cord-005453-4057qib7 3241 9 and and CC cord-005453-4057qib7 3241 10 faculty faculty NN cord-005453-4057qib7 3241 11 recommendations recommendation NNS cord-005453-4057qib7 3241 12 was be VBD cord-005453-4057qib7 3241 13 provided provide VBN cord-005453-4057qib7 3241 14 after after IN cord-005453-4057qib7 3241 15 each each DT cord-005453-4057qib7 3241 16 decision decision NN cord-005453-4057qib7 3241 17 . . . cord-005453-4057qib7 3242 1 One one CD cord-005453-4057qib7 3242 2 case case NN cord-005453-4057qib7 3242 3 was be VBD cord-005453-4057qib7 3242 4 about about IN cord-005453-4057qib7 3242 5 VOD VOD NNP cord-005453-4057qib7 3242 6 and and CC cord-005453-4057qib7 3242 7 the the DT cord-005453-4057qib7 3242 8 other other JJ cord-005453-4057qib7 3242 9 case case NN cord-005453-4057qib7 3242 10 was be VBD cord-005453-4057qib7 3242 11 about about IN cord-005453-4057qib7 3242 12 acute acute JJ cord-005453-4057qib7 3242 13 myeloid myeloid NN cord-005453-4057qib7 3242 14 leukemia leukemia NN cord-005453-4057qib7 3242 15 ( ( -LRB- cord-005453-4057qib7 3242 16 AML AML NNP cord-005453-4057qib7 3242 17 ) ) -RRB- cord-005453-4057qib7 3242 18 . . . cord-005453-4057qib7 3243 1 Decisions decision NNS cord-005453-4057qib7 3243 2 were be VBD cord-005453-4057qib7 3243 3 collected collect VBN cord-005453-4057qib7 3243 4 post post JJ cord-005453-4057qib7 3243 5 - - JJ cord-005453-4057qib7 3243 6 CG cg JJ cord-005453-4057qib7 3243 7 and and CC cord-005453-4057qib7 3243 8 compared compare VBN cord-005453-4057qib7 3243 9 with with IN cord-005453-4057qib7 3243 10 each each DT cord-005453-4057qib7 3243 11 user user NN cord-005453-4057qib7 3243 12 's 's POS cord-005453-4057qib7 3243 13 baseline baseline JJ cord-005453-4057qib7 3243 14 ( ( -LRB- cord-005453-4057qib7 3243 15 pre pre JJ cord-005453-4057qib7 3243 16 - - JJ cord-005453-4057qib7 3243 17 CG cg JJ cord-005453-4057qib7 3243 18 ) ) -RRB- cord-005453-4057qib7 3243 19 decisions decision NNS cord-005453-4057qib7 3243 20 using use VBG cord-005453-4057qib7 3243 21 a a DT cord-005453-4057qib7 3243 22 2-tailed 2-tailed CD cord-005453-4057qib7 3243 23 paired paired JJ cord-005453-4057qib7 3243 24 t t NN cord-005453-4057qib7 3243 25 - - HYPH cord-005453-4057qib7 3243 26 test test NN cord-005453-4057qib7 3243 27 to to TO cord-005453-4057qib7 3243 28 determine determine VB cord-005453-4057qib7 3243 29 p p NN cord-005453-4057qib7 3243 30 - - HYPH cord-005453-4057qib7 3243 31 values value NNS cord-005453-4057qib7 3243 32 ( ( -LRB- cord-005453-4057qib7 3243 33 P p NN cord-005453-4057qib7 3243 34 < < XX cord-005453-4057qib7 3243 35 .05 .05 NFP cord-005453-4057qib7 3243 36 indicates indicate VBZ cord-005453-4057qib7 3243 37 significance significance NN cord-005453-4057qib7 3243 38 ) ) -RRB- cord-005453-4057qib7 3243 39 . . . cord-005453-4057qib7 3244 1 Data datum NNS cord-005453-4057qib7 3244 2 were be VBD cord-005453-4057qib7 3244 3 collected collect VBN cord-005453-4057qib7 3244 4 between between IN cord-005453-4057qib7 3244 5 9/21/2017 9/21/2017 CD cord-005453-4057qib7 3244 6 and and CC cord-005453-4057qib7 3244 7 11/7/2018 11/7/2018 CD cord-005453-4057qib7 3244 8 . . . cord-005453-4057qib7 3245 1 Results result NNS cord-005453-4057qib7 3245 2 : : : cord-005453-4057qib7 3246 1 At at IN cord-005453-4057qib7 3246 2 the the DT cord-005453-4057qib7 3246 3 time time NN cord-005453-4057qib7 3246 4 of of IN cord-005453-4057qib7 3246 5 assessment assessment NN cord-005453-4057qib7 3246 6 , , , cord-005453-4057qib7 3246 7 115 115 CD cord-005453-4057qib7 3246 8 hem hem NNP cord-005453-4057qib7 3246 9 / / SYM cord-005453-4057qib7 3246 10 oncs oncs NN cord-005453-4057qib7 3246 11 and and CC cord-005453-4057qib7 3246 12 409 409 CD cord-005453-4057qib7 3246 13 APPs app NNS cord-005453-4057qib7 3246 14 had have VBD cord-005453-4057qib7 3246 15 fulfilled fulfil VBN cord-005453-4057qib7 3246 16 the the DT cord-005453-4057qib7 3246 17 participation participation NN cord-005453-4057qib7 3246 18 criteria criterion NNS cord-005453-4057qib7 3246 19 for for IN cord-005453-4057qib7 3246 20 completing complete VBG cord-005453-4057qib7 3246 21 the the DT cord-005453-4057qib7 3246 22 VOD VOD NNP cord-005453-4057qib7 3246 23 case case NN cord-005453-4057qib7 3246 24 simulation simulation NN cord-005453-4057qib7 3246 25 . . . cord-005453-4057qib7 3247 1 Conclusions conclusion NNS cord-005453-4057qib7 3247 2 : : : cord-005453-4057qib7 3248 1 This this DT cord-005453-4057qib7 3248 2 study study NN cord-005453-4057qib7 3248 3 demonstrates demonstrate VBZ cord-005453-4057qib7 3248 4 that that IN cord-005453-4057qib7 3248 5 VPS VPS NNP cord-005453-4057qib7 3248 6 that that WDT cord-005453-4057qib7 3248 7 immersed immerse VBD cord-005453-4057qib7 3248 8 and and CC cord-005453-4057qib7 3248 9 engaged engage VBD cord-005453-4057qib7 3248 10 clinicians clinician NNS cord-005453-4057qib7 3248 11 in in IN cord-005453-4057qib7 3248 12 an an DT cord-005453-4057qib7 3248 13 authentic authentic JJ cord-005453-4057qib7 3248 14 and and CC cord-005453-4057qib7 3248 15 practical practical JJ cord-005453-4057qib7 3248 16 learning learning NN cord-005453-4057qib7 3248 17 experience experience NN cord-005453-4057qib7 3248 18 improved improve VBD cord-005453-4057qib7 3248 19 evidence evidence NN cord-005453-4057qib7 3248 20 - - HYPH cord-005453-4057qib7 3248 21 based base VBN cord-005453-4057qib7 3248 22 clinical clinical JJ cord-005453-4057qib7 3248 23 decisions decision NNS cord-005453-4057qib7 3248 24 related relate VBN cord-005453-4057qib7 3248 25 to to IN cord-005453-4057qib7 3248 26 the the DT cord-005453-4057qib7 3248 27 management management NN cord-005453-4057qib7 3248 28 of of IN cord-005453-4057qib7 3248 29 VOD VOD NNP cord-005453-4057qib7 3248 30 . . . cord-005453-4057qib7 3249 1 This this DT cord-005453-4057qib7 3249 2 VPS VPS NNP cord-005453-4057qib7 3249 3 increased increase VBD cord-005453-4057qib7 3249 4 the the DT cord-005453-4057qib7 3249 5 percentage percentage NN cord-005453-4057qib7 3249 6 of of IN cord-005453-4057qib7 3249 7 clinicians clinician NNS cord-005453-4057qib7 3249 8 who who WP cord-005453-4057qib7 3249 9 utilized utilize VBD cord-005453-4057qib7 3249 10 standardized standardized JJ cord-005453-4057qib7 3249 11 criteria criterion NNS cord-005453-4057qib7 3249 12 to to TO cord-005453-4057qib7 3249 13 diagnose diagnose VB cord-005453-4057qib7 3249 14 VOD VOD NNP cord-005453-4057qib7 3249 15 and and CC cord-005453-4057qib7 3249 16 who who WP cord-005453-4057qib7 3249 17 ordered order VBD cord-005453-4057qib7 3249 18 defibrotide defibrotide NN cord-005453-4057qib7 3249 19 and and CC cord-005453-4057qib7 3249 20 IV IV NNP cord-005453-4057qib7 3249 21 fluids fluid NNS cord-005453-4057qib7 3249 22 for for IN cord-005453-4057qib7 3249 23 VOD VOD NNP cord-005453-4057qib7 3249 24 management management NN cord-005453-4057qib7 3249 25 . . . cord-005453-4057qib7 3250 1 However however RB cord-005453-4057qib7 3250 2 , , , cord-005453-4057qib7 3250 3 further further JJ cord-005453-4057qib7 3250 4 education education NN cord-005453-4057qib7 3250 5 is be VBZ cord-005453-4057qib7 3250 6 needed need VBN cord-005453-4057qib7 3250 7 to to TO cord-005453-4057qib7 3250 8 increase increase VB cord-005453-4057qib7 3250 9 the the DT cord-005453-4057qib7 3250 10 competence competence NN cord-005453-4057qib7 3250 11 and and CC cord-005453-4057qib7 3250 12 performance performance NN cord-005453-4057qib7 3250 13 of of IN cord-005453-4057qib7 3250 14 clinicians clinician NNS cord-005453-4057qib7 3250 15 , , , cord-005453-4057qib7 3250 16 particularly particularly RB cord-005453-4057qib7 3250 17 APPs app NNS cord-005453-4057qib7 3250 18 , , , cord-005453-4057qib7 3250 19 in in IN cord-005453-4057qib7 3250 20 these these DT cord-005453-4057qib7 3250 21 areas area NNS cord-005453-4057qib7 3250 22 in in IN cord-005453-4057qib7 3250 23 order order NN cord-005453-4057qib7 3250 24 to to TO cord-005453-4057qib7 3250 25 positively positively RB cord-005453-4057qib7 3250 26 impact impact VB cord-005453-4057qib7 3250 27 patients patient NNS cord-005453-4057qib7 3250 28 . . . cord-005453-4057qib7 3251 1 Disclosure disclosure NN cord-005453-4057qib7 3251 2 : : : cord-005453-4057qib7 3251 3 Nothing nothing NN cord-005453-4057qib7 3251 4 to to TO cord-005453-4057qib7 3251 5 declare declare VB cord-005453-4057qib7 3251 6 . . . cord-005453-4057qib7 3252 1 A a DT cord-005453-4057qib7 3252 2 nationwide nationwide JJ cord-005453-4057qib7 3252 3 retrospective retrospective JJ cord-005453-4057qib7 3252 4 study study NN cord-005453-4057qib7 3252 5 of of IN cord-005453-4057qib7 3252 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 3252 7 stem stem NN cord-005453-4057qib7 3252 8 cell cell NN cord-005453-4057qib7 3252 9 transplantation transplantation NN cord-005453-4057qib7 3252 10 in in IN cord-005453-4057qib7 3252 11 solid solid JJ cord-005453-4057qib7 3252 12 organ organ NN cord-005453-4057qib7 3252 13 transplant transplant NN cord-005453-4057qib7 3252 14 recipients recipient NNS cord-005453-4057qib7 3252 15 : : : cord-005453-4057qib7 3252 16 On on IN cord-005453-4057qib7 3252 17 behalf behalf NN cord-005453-4057qib7 3252 18 of of IN cord-005453-4057qib7 3252 19 JSHCT JSHCT NNP cord-005453-4057qib7 3252 20 , , , cord-005453-4057qib7 3252 21 transplant transplant NN cord-005453-4057qib7 3252 22 complications complication NNS cord-005453-4057qib7 3252 23 working work VBG cord-005453-4057qib7 3252 24 group group NN cord-005453-4057qib7 3252 25 Background Background NNP cord-005453-4057qib7 3252 26 : : : cord-005453-4057qib7 3252 27 The the DT cord-005453-4057qib7 3252 28 outcome outcome NN cord-005453-4057qib7 3252 29 of of IN cord-005453-4057qib7 3252 30 hematopoietic hematopoietic JJ cord-005453-4057qib7 3252 31 stem stem NN cord-005453-4057qib7 3252 32 cell cell NN cord-005453-4057qib7 3252 33 transplantation transplantation NN cord-005453-4057qib7 3252 34 ( ( -LRB- cord-005453-4057qib7 3252 35 HSCT HSCT NNP cord-005453-4057qib7 3252 36 ) ) -RRB- cord-005453-4057qib7 3252 37 in in IN cord-005453-4057qib7 3252 38 solid solid JJ cord-005453-4057qib7 3252 39 organ organ NN cord-005453-4057qib7 3252 40 transplant transplant NN cord-005453-4057qib7 3252 41 remain remain VBP cord-005453-4057qib7 3252 42 unclear unclear JJ cord-005453-4057qib7 3252 43 . . . cord-005453-4057qib7 3253 1 To to TO cord-005453-4057qib7 3253 2 address address VB cord-005453-4057qib7 3253 3 this this DT cord-005453-4057qib7 3253 4 issue issue NN cord-005453-4057qib7 3253 5 , , , cord-005453-4057qib7 3253 6 we -PRON- PRP cord-005453-4057qib7 3253 7 conducted conduct VBD cord-005453-4057qib7 3253 8 a a DT cord-005453-4057qib7 3253 9 retrospective retrospective JJ cord-005453-4057qib7 3253 10 survey survey NN cord-005453-4057qib7 3253 11 of of IN cord-005453-4057qib7 3253 12 the the DT cord-005453-4057qib7 3253 13 404 404 CD cord-005453-4057qib7 3253 14 Japan Japan NNP cord-005453-4057qib7 3253 15 Society Society NNP cord-005453-4057qib7 3253 16 for for IN cord-005453-4057qib7 3253 17 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 3253 18 Stem Stem NNP cord-005453-4057qib7 3253 19 Cell Cell NNP cord-005453-4057qib7 3253 20 Transplantation transplantation NN cord-005453-4057qib7 3253 21 centers center NNS cord-005453-4057qib7 3253 22 . . . cord-005453-4057qib7 3254 1 Methods method NNS cord-005453-4057qib7 3254 2 : : : cord-005453-4057qib7 3254 3 To to TO cord-005453-4057qib7 3254 4 address address VB cord-005453-4057qib7 3254 5 this this DT cord-005453-4057qib7 3254 6 issue issue NN cord-005453-4057qib7 3254 7 , , , cord-005453-4057qib7 3254 8 we -PRON- PRP cord-005453-4057qib7 3254 9 conducted conduct VBD cord-005453-4057qib7 3254 10 a a DT cord-005453-4057qib7 3254 11 nationwide nationwide JJ cord-005453-4057qib7 3254 12 retrospective retrospective JJ cord-005453-4057qib7 3254 13 survey survey NN cord-005453-4057qib7 3254 14 of of IN cord-005453-4057qib7 3254 15 the the DT cord-005453-4057qib7 3254 16 Japan Japan NNP cord-005453-4057qib7 3254 17 Society Society NNP cord-005453-4057qib7 3254 18 for for IN cord-005453-4057qib7 3254 19 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 3254 20 Stem Stem NNP cord-005453-4057qib7 3254 21 Cell Cell NNP cord-005453-4057qib7 3254 22 Transplantation transplantation NN cord-005453-4057qib7 3254 23 ( ( -LRB- cord-005453-4057qib7 3254 24 JSHCT JSHCT NNP cord-005453-4057qib7 3254 25 ) ) -RRB- cord-005453-4057qib7 3254 26 centers center NNS cord-005453-4057qib7 3254 27 . . . cord-005453-4057qib7 3255 1 A a DT cord-005453-4057qib7 3255 2 first first JJ cord-005453-4057qib7 3255 3 questionnaire questionnaire NN cord-005453-4057qib7 3255 4 was be VBD cord-005453-4057qib7 3255 5 emailed email VBN cord-005453-4057qib7 3255 6 to to IN cord-005453-4057qib7 3255 7 JSHCT JSHCT NNP cord-005453-4057qib7 3255 8 centers center NNS cord-005453-4057qib7 3255 9 requesting request VBG cord-005453-4057qib7 3255 10 information information NN cord-005453-4057qib7 3255 11 on on IN cord-005453-4057qib7 3255 12 cases case NNS cord-005453-4057qib7 3255 13 of of IN cord-005453-4057qib7 3255 14 HSCT HSCT NNP cord-005453-4057qib7 3255 15 in in IN cord-005453-4057qib7 3255 16 SOT SOT NNP cord-005453-4057qib7 3255 17 recipient recipient NN cord-005453-4057qib7 3255 18 . . . cord-005453-4057qib7 3256 1 Patients patient NNS cord-005453-4057qib7 3256 2 ' ' POS cord-005453-4057qib7 3256 3 data datum NNS cord-005453-4057qib7 3256 4 about about IN cord-005453-4057qib7 3256 5 SOT SOT NNP cord-005453-4057qib7 3256 6 were be VBD cord-005453-4057qib7 3256 7 collected collect VBN cord-005453-4057qib7 3256 8 by by IN cord-005453-4057qib7 3256 9 sending send VBG cord-005453-4057qib7 3256 10 a a DT cord-005453-4057qib7 3256 11 second second JJ cord-005453-4057qib7 3256 12 questionnaire questionnaire NN cord-005453-4057qib7 3256 13 to to IN cord-005453-4057qib7 3256 14 the the DT cord-005453-4057qib7 3256 15 centers center NNS cord-005453-4057qib7 3256 16 with with IN cord-005453-4057qib7 3256 17 the the DT cord-005453-4057qib7 3256 18 patient patient NN cord-005453-4057qib7 3256 19 . . . cord-005453-4057qib7 3257 1 Based base VBN cord-005453-4057qib7 3257 2 on on IN cord-005453-4057qib7 3257 3 these these DT cord-005453-4057qib7 3257 4 reports report NNS cord-005453-4057qib7 3257 5 , , , cord-005453-4057qib7 3257 6 patients patient NNS cord-005453-4057qib7 3257 7 ' ' POS cord-005453-4057qib7 3257 8 data datum NNS cord-005453-4057qib7 3257 9 about about IN cord-005453-4057qib7 3257 10 HSCT HSCT NNP cord-005453-4057qib7 3257 11 was be VBD cord-005453-4057qib7 3257 12 identified identify VBN cord-005453-4057qib7 3257 13 in in IN cord-005453-4057qib7 3257 14 the the DT cord-005453-4057qib7 3257 15 Japan Japan NNP cord-005453-4057qib7 3257 16 transplant transplant NN cord-005453-4057qib7 3257 17 outcomes outcome NNS cord-005453-4057qib7 3257 18 registry registry NN cord-005453-4057qib7 3257 19 database database NN cord-005453-4057qib7 3257 20 by by IN cord-005453-4057qib7 3257 21 the the DT cord-005453-4057qib7 3257 22 Transplant Transplant NNP cord-005453-4057qib7 3257 23 Registry Registry NNP cord-005453-4057qib7 3257 24 Unified Unified NNP cord-005453-4057qib7 3257 25 Management Management NNP cord-005453-4057qib7 3257 26 Program Program NNP cord-005453-4057qib7 3257 27 ( ( -LRB- cord-005453-4057qib7 3257 28 TRUMP TRUMP NNP cord-005453-4057qib7 3257 29 ) ) -RRB- cord-005453-4057qib7 3257 30 , , , cord-005453-4057qib7 3257 31 confirmed confirm VBD cord-005453-4057qib7 3257 32 in in IN cord-005453-4057qib7 3257 33 2017 2017 CD cord-005453-4057qib7 3257 34 . . . cord-005453-4057qib7 3258 1 Results result NNS cord-005453-4057qib7 3258 2 : : : cord-005453-4057qib7 3259 1 Of of IN cord-005453-4057qib7 3259 2 the the DT cord-005453-4057qib7 3259 3 404 404 CD cord-005453-4057qib7 3259 4 JSHCT JSHCT NNP cord-005453-4057qib7 3259 5 centers center NNS cord-005453-4057qib7 3259 6 , , , cord-005453-4057qib7 3259 7 238 238 CD cord-005453-4057qib7 3259 8 responded respond VBD cord-005453-4057qib7 3259 9 to to IN cord-005453-4057qib7 3259 10 the the DT cord-005453-4057qib7 3259 11 survey survey NN cord-005453-4057qib7 3259 12 ( ( -LRB- cord-005453-4057qib7 3259 13 58.9 58.9 CD cord-005453-4057qib7 3259 14 % % NN cord-005453-4057qib7 3259 15 ) ) -RRB- cord-005453-4057qib7 3259 16 . . . cord-005453-4057qib7 3260 1 14 14 CD cord-005453-4057qib7 3260 2 of of IN cord-005453-4057qib7 3260 3 the the DT cord-005453-4057qib7 3260 4 responding respond VBG cord-005453-4057qib7 3260 5 centers center NNS cord-005453-4057qib7 3260 6 reported report VBD cord-005453-4057qib7 3260 7 a a DT cord-005453-4057qib7 3260 8 total total NN cord-005453-4057qib7 3260 9 of of IN cord-005453-4057qib7 3260 10 19 19 CD cord-005453-4057qib7 3260 11 patients patient NNS cord-005453-4057qib7 3260 12 who who WP cord-005453-4057qib7 3260 13 had have VBD cord-005453-4057qib7 3260 14 undergone undergo VBN cord-005453-4057qib7 3260 15 SOT SOT NNP cord-005453-4057qib7 3260 16 from from IN cord-005453-4057qib7 3260 17 living live VBG cord-005453-4057qib7 3260 18 donor donor NN cord-005453-4057qib7 3260 19 , , , cord-005453-4057qib7 3260 20 and and CC cord-005453-4057qib7 3260 21 subsequent subsequent JJ cord-005453-4057qib7 3260 22 HSCT HSCT NNP cord-005453-4057qib7 3260 23 . . . cord-005453-4057qib7 3261 1 They -PRON- PRP cord-005453-4057qib7 3261 2 consist consist VBP cord-005453-4057qib7 3261 3 of of IN cord-005453-4057qib7 3261 4 three three CD cord-005453-4057qib7 3261 5 autologous autologous JJ cord-005453-4057qib7 3261 6 HSCT HSCT NNP cord-005453-4057qib7 3261 7 ( ( -LRB- cord-005453-4057qib7 3261 8 auto auto NN cord-005453-4057qib7 3261 9 - - HYPH cord-005453-4057qib7 3261 10 HSCT HSCT NNP cord-005453-4057qib7 3261 11 ) ) -RRB- cord-005453-4057qib7 3261 12 and and CC cord-005453-4057qib7 3261 13 13 13 CD cord-005453-4057qib7 3261 14 allogeneic allogeneic NN cord-005453-4057qib7 3261 15 HSCT HSCT NNP cord-005453-4057qib7 3261 16 ( ( -LRB- cord-005453-4057qib7 3261 17 allo allo NN cord-005453-4057qib7 3261 18 - - HYPH cord-005453-4057qib7 3261 19 HSCT HSCT NNP cord-005453-4057qib7 3261 20 ) ) -RRB- cord-005453-4057qib7 3261 21 . . . cord-005453-4057qib7 3262 1 In in IN cord-005453-4057qib7 3262 2 auto auto NN cord-005453-4057qib7 3262 3 - - HYPH cord-005453-4057qib7 3262 4 HSCT HSCT NNP cord-005453-4057qib7 3262 5 , , , cord-005453-4057qib7 3262 6 all all DT cord-005453-4057qib7 3262 7 patients patient NNS cord-005453-4057qib7 3262 8 had have VBD cord-005453-4057qib7 3262 9 received receive VBN cord-005453-4057qib7 3262 10 liver liver NN cord-005453-4057qib7 3262 11 transplant transplant NN cord-005453-4057qib7 3262 12 for for IN cord-005453-4057qib7 3262 13 hapatoblastoma hapatoblastoma NNP cord-005453-4057qib7 3262 14 . . . cord-005453-4057qib7 3263 1 They -PRON- PRP cord-005453-4057qib7 3263 2 achieved achieve VBD cord-005453-4057qib7 3263 3 neutrophil neutrophil NN cord-005453-4057qib7 3263 4 engraftment engraftment NN cord-005453-4057qib7 3263 5 at at IN cord-005453-4057qib7 3263 6 30 30 CD cord-005453-4057qib7 3263 7 days day NNS cord-005453-4057qib7 3263 8 after after IN cord-005453-4057qib7 3263 9 HSCT HSCT NNP cord-005453-4057qib7 3263 10 , , , cord-005453-4057qib7 3263 11 and and CC cord-005453-4057qib7 3263 12 two two CD cord-005453-4057qib7 3263 13 of of IN cord-005453-4057qib7 3263 14 three three CD cord-005453-4057qib7 3263 15 patients patient NNS cord-005453-4057qib7 3263 16 were be VBD cord-005453-4057qib7 3263 17 alive alive JJ cord-005453-4057qib7 3263 18 at at IN cord-005453-4057qib7 3263 19 one one CD cord-005453-4057qib7 3263 20 year year NN cord-005453-4057qib7 3263 21 after after IN cord-005453-4057qib7 3263 22 HSCT HSCT NNP cord-005453-4057qib7 3263 23 . . . cord-005453-4057qib7 3264 1 In in IN cord-005453-4057qib7 3264 2 allo allo NN cord-005453-4057qib7 3264 3 - - HYPH cord-005453-4057qib7 3264 4 HSCT HSCT NNP cord-005453-4057qib7 3264 5 ( ( -LRB- cord-005453-4057qib7 3264 6 n=16 n=16 NNP cord-005453-4057qib7 3264 7 ) ) -RRB- cord-005453-4057qib7 3264 8 , , , cord-005453-4057qib7 3264 9 seven seven CD cord-005453-4057qib7 3264 10 patients patient NNS cord-005453-4057qib7 3264 11 had have VBD cord-005453-4057qib7 3264 12 received receive VBN cord-005453-4057qib7 3264 13 liver liver NN cord-005453-4057qib7 3264 14 transplants transplant NNS cord-005453-4057qib7 3264 15 , , , cord-005453-4057qib7 3264 16 and and CC cord-005453-4057qib7 3264 17 nine nine CD cord-005453-4057qib7 3264 18 patients patient NNS cord-005453-4057qib7 3264 19 had have VBD cord-005453-4057qib7 3264 20 received receive VBN cord-005453-4057qib7 3264 21 kidney kidney NN cord-005453-4057qib7 3264 22 transplants transplant NNS cord-005453-4057qib7 3264 23 . . . cord-005453-4057qib7 3265 1 Five five CD cord-005453-4057qib7 3265 2 patients patient NNS cord-005453-4057qib7 3265 3 received receive VBD cord-005453-4057qib7 3265 4 HSCT HSCT NNP cord-005453-4057qib7 3265 5 from from IN cord-005453-4057qib7 3265 6 unrelated unrelated JJ cord-005453-4057qib7 3265 7 donor donor NN cord-005453-4057qib7 3265 8 , , , cord-005453-4057qib7 3265 9 and and CC cord-005453-4057qib7 3265 10 11 11 CD cord-005453-4057qib7 3265 11 patients patient NNS cord-005453-4057qib7 3265 12 received receive VBD cord-005453-4057qib7 3265 13 HSCT HSCT NNP cord-005453-4057qib7 3265 14 from from IN cord-005453-4057qib7 3265 15 related related JJ cord-005453-4057qib7 3265 16 donor donor NN cord-005453-4057qib7 3265 17 ; ; : cord-005453-4057qib7 3265 18 two two CD cord-005453-4057qib7 3265 19 donors donor NNS cord-005453-4057qib7 3265 20 were be VBD cord-005453-4057qib7 3265 21 identical identical JJ cord-005453-4057qib7 3265 22 in in IN cord-005453-4057qib7 3265 23 SOT SOT NNP cord-005453-4057qib7 3265 24 . . . cord-005453-4057qib7 3266 1 Their -PRON- PRP$ cord-005453-4057qib7 3266 2 stem stem NN cord-005453-4057qib7 3266 3 cell cell NN cord-005453-4057qib7 3266 4 sources source NNS cord-005453-4057qib7 3266 5 were be VBD cord-005453-4057qib7 3266 6 seven seven CD cord-005453-4057qib7 3266 7 peripheral peripheral JJ cord-005453-4057qib7 3266 8 blood blood NN cord-005453-4057qib7 3266 9 stem stem NN cord-005453-4057qib7 3266 10 cell cell NN cord-005453-4057qib7 3266 11 , , , cord-005453-4057qib7 3266 12 six six CD cord-005453-4057qib7 3266 13 bone bone NN cord-005453-4057qib7 3266 14 marrow marrow NN cord-005453-4057qib7 3266 15 , , , cord-005453-4057qib7 3266 16 and and CC cord-005453-4057qib7 3266 17 three three CD cord-005453-4057qib7 3266 18 cord cord NN cord-005453-4057qib7 3266 19 blood blood NN cord-005453-4057qib7 3266 20 . . . cord-005453-4057qib7 3267 1 All all DT cord-005453-4057qib7 3267 2 but but IN cord-005453-4057qib7 3267 3 one one CD cord-005453-4057qib7 3267 4 patients patient NNS cord-005453-4057qib7 3267 5 achieved achieve VBD cord-005453-4057qib7 3267 6 neutrophil neutrophil NN cord-005453-4057qib7 3267 7 engraftment engraftment NN cord-005453-4057qib7 3267 8 at at IN cord-005453-4057qib7 3267 9 30 30 CD cord-005453-4057qib7 3267 10 days day NNS cord-005453-4057qib7 3267 11 after after IN cord-005453-4057qib7 3267 12 HSCT HSCT NNP cord-005453-4057qib7 3267 13 . . . cord-005453-4057qib7 3268 1 Five five CD cord-005453-4057qib7 3268 2 - - HYPH cord-005453-4057qib7 3268 3 year year NN cord-005453-4057qib7 3268 4 overall overall JJ cord-005453-4057qib7 3268 5 survival survival NN cord-005453-4057qib7 3268 6 ( ( -LRB- cord-005453-4057qib7 3268 7 5yOS 5yOS NNP cord-005453-4057qib7 3268 8 ) ) -RRB- cord-005453-4057qib7 3268 9 was be VBD cord-005453-4057qib7 3268 10 37.5 37.5 CD cord-005453-4057qib7 3268 11 % % NN cord-005453-4057qib7 3268 12 . . . cord-005453-4057qib7 3269 1 While while IN cord-005453-4057qib7 3269 2 5yOS 5yos CD cord-005453-4057qib7 3269 3 in in IN cord-005453-4057qib7 3269 4 patients patient NNS cord-005453-4057qib7 3269 5 with with IN cord-005453-4057qib7 3269 6 bone bone NN cord-005453-4057qib7 3269 7 marrow marrow NN cord-005453-4057qib7 3269 8 failure failure NN cord-005453-4057qib7 3269 9 ( ( -LRB- cord-005453-4057qib7 3269 10 n=4 n=4 NNS cord-005453-4057qib7 3269 11 ) ) -RRB- cord-005453-4057qib7 3269 12 was be VBD cord-005453-4057qib7 3269 13 100 100 CD cord-005453-4057qib7 3269 14 % % NN cord-005453-4057qib7 3269 15 , , , cord-005453-4057qib7 3269 16 that that IN cord-005453-4057qib7 3269 17 in in IN cord-005453-4057qib7 3269 18 patients patient NNS cord-005453-4057qib7 3269 19 with with IN cord-005453-4057qib7 3269 20 malignant malignant JJ cord-005453-4057qib7 3269 21 disease disease NN cord-005453-4057qib7 3269 22 ( ( -LRB- cord-005453-4057qib7 3269 23 n=12 n=12 NNP cord-005453-4057qib7 3269 24 ) ) -RRB- cord-005453-4057qib7 3269 25 was be VBD cord-005453-4057qib7 3269 26 16.7 16.7 CD cord-005453-4057qib7 3269 27 % % NN cord-005453-4057qib7 3269 28 ; ; . cord-005453-4057qib7 3270 1 all all DT cord-005453-4057qib7 3270 2 but but IN cord-005453-4057qib7 3270 3 one one CD cord-005453-4057qib7 3270 4 patients patient NNS cord-005453-4057qib7 3270 5 with with IN cord-005453-4057qib7 3270 6 malignant malignant JJ cord-005453-4057qib7 3270 7 disease disease NN cord-005453-4057qib7 3270 8 received receive VBD cord-005453-4057qib7 3270 9 allo allo NN cord-005453-4057qib7 3270 10 - - HYPH cord-005453-4057qib7 3270 11 HSCT HSCT NNP cord-005453-4057qib7 3270 12 in in IN cord-005453-4057qib7 3270 13 non non JJ cord-005453-4057qib7 3270 14 - - JJ cord-005453-4057qib7 3270 15 remission remission NN cord-005453-4057qib7 3270 16 . . . cord-005453-4057qib7 3271 1 Seven seven CD cord-005453-4057qib7 3271 2 of of IN cord-005453-4057qib7 3271 3 nine nine CD cord-005453-4057qib7 3271 4 kidney kidney NN cord-005453-4057qib7 3271 5 - - HYPH cord-005453-4057qib7 3271 6 transplant transplant NN cord-005453-4057qib7 3271 7 recipients recipient NNS cord-005453-4057qib7 3271 8 experienced experience VBD cord-005453-4057qib7 3271 9 dialysis dialysis NN cord-005453-4057qib7 3271 10 , , , cord-005453-4057qib7 3271 11 and and CC cord-005453-4057qib7 3271 12 three three CD cord-005453-4057qib7 3271 13 patients patient NNS cord-005453-4057qib7 3271 14 experienced experience VBD cord-005453-4057qib7 3271 15 renal renal JJ cord-005453-4057qib7 3271 16 rejection rejection NN cord-005453-4057qib7 3271 17 after after IN cord-005453-4057qib7 3271 18 HSCT HSCT NNP cord-005453-4057qib7 3271 19 . . . cord-005453-4057qib7 3272 1 On on IN cord-005453-4057qib7 3272 2 the the DT cord-005453-4057qib7 3272 3 contrary contrary NN cord-005453-4057qib7 3272 4 , , , cord-005453-4057qib7 3272 5 no no DT cord-005453-4057qib7 3272 6 liver liver NN cord-005453-4057qib7 3272 7 - - HYPH cord-005453-4057qib7 3272 8 transplant transplant NN cord-005453-4057qib7 3272 9 recipient recipient NN cord-005453-4057qib7 3272 10 experienced experience VBD cord-005453-4057qib7 3272 11 hepatic hepatic JJ cord-005453-4057qib7 3272 12 rejection rejection NN cord-005453-4057qib7 3272 13 . . . cord-005453-4057qib7 3273 1 Conclusions conclusion NNS cord-005453-4057qib7 3273 2 : : : cord-005453-4057qib7 3274 1 In in IN cord-005453-4057qib7 3274 2 SOT SOT NNP cord-005453-4057qib7 3274 3 recipients recipient NNS cord-005453-4057qib7 3274 4 , , , cord-005453-4057qib7 3274 5 the the DT cord-005453-4057qib7 3274 6 outcome outcome NN cord-005453-4057qib7 3274 7 of of IN cord-005453-4057qib7 3274 8 allo allo NN cord-005453-4057qib7 3274 9 - - HYPH cord-005453-4057qib7 3274 10 HSCT HSCT NNP cord-005453-4057qib7 3274 11 for for IN cord-005453-4057qib7 3274 12 malignant malignant JJ cord-005453-4057qib7 3274 13 disease disease NN cord-005453-4057qib7 3274 14 was be VBD cord-005453-4057qib7 3274 15 poor poor JJ cord-005453-4057qib7 3274 16 , , , cord-005453-4057qib7 3274 17 partly partly RB cord-005453-4057qib7 3274 18 due due JJ cord-005453-4057qib7 3274 19 to to IN cord-005453-4057qib7 3274 20 disease disease NN cord-005453-4057qib7 3274 21 status status NN cord-005453-4057qib7 3274 22 before before IN cord-005453-4057qib7 3274 23 allo allo NN cord-005453-4057qib7 3274 24 - - HYPH cord-005453-4057qib7 3274 25 HSCT HSCT NNP cord-005453-4057qib7 3274 26 . . . cord-005453-4057qib7 3275 1 Severe severe JJ cord-005453-4057qib7 3275 2 renal renal JJ cord-005453-4057qib7 3275 3 complications complication NNS cord-005453-4057qib7 3275 4 were be VBD cord-005453-4057qib7 3275 5 common common JJ cord-005453-4057qib7 3275 6 in in IN cord-005453-4057qib7 3275 7 kidney kidney NN cord-005453-4057qib7 3275 8 - - HYPH cord-005453-4057qib7 3275 9 transplant transplant NN cord-005453-4057qib7 3275 10 recipients recipient NNS cord-005453-4057qib7 3275 11 , , , cord-005453-4057qib7 3275 12 suggesting suggest VBG cord-005453-4057qib7 3275 13 renal renal JJ cord-005453-4057qib7 3275 14 care care NN cord-005453-4057qib7 3275 15 with with IN cord-005453-4057qib7 3275 16 caution caution NN cord-005453-4057qib7 3275 17 during during IN cord-005453-4057qib7 3275 18 and and CC cord-005453-4057qib7 3275 19 after after IN cord-005453-4057qib7 3275 20 allo allo NN cord-005453-4057qib7 3275 21 - - HYPH cord-005453-4057qib7 3275 22 HSCT HSCT NNP cord-005453-4057qib7 3275 23 . . . cord-005453-4057qib7 3276 1 Disclosure disclosure NN cord-005453-4057qib7 3276 2 : : : cord-005453-4057qib7 3277 1 This this DT cord-005453-4057qib7 3277 2 work work NN cord-005453-4057qib7 3277 3 was be VBD cord-005453-4057qib7 3277 4 supported support VBN cord-005453-4057qib7 3277 5 in in IN cord-005453-4057qib7 3277 6 part part NN cord-005453-4057qib7 3277 7 by by IN cord-005453-4057qib7 3277 8 the the DT cord-005453-4057qib7 3277 9 Practical Practical NNP cord-005453-4057qib7 3277 10 Research Research NNP cord-005453-4057qib7 3277 11 Project Project NNP cord-005453-4057qib7 3277 12 for for IN cord-005453-4057qib7 3277 13 Allergic Allergic NNP cord-005453-4057qib7 3277 14 Diseases Diseases NNPS cord-005453-4057qib7 3277 15 and and CC cord-005453-4057qib7 3277 16 Immunology Immunology NNP cord-005453-4057qib7 3277 17 ( ( -LRB- cord-005453-4057qib7 3277 18 Research Research NNP cord-005453-4057qib7 3277 19 Technology Technology NNP cord-005453-4057qib7 3277 20 of of IN cord-005453-4057qib7 3277 21 Medical Medical NNP cord-005453-4057qib7 3277 22 Transplantation Transplantation NNP cord-005453-4057qib7 3277 23 ) ) -RRB- cord-005453-4057qib7 3277 24 from from IN cord-005453-4057qib7 3277 25 Japan Japan NNP cord-005453-4057qib7 3277 26 Agency Agency NNP cord-005453-4057qib7 3277 27 for for IN cord-005453-4057qib7 3277 28 Medical Medical NNP cord-005453-4057qib7 3277 29 Research Research NNP cord-005453-4057qib7 3277 30 and and CC cord-005453-4057qib7 3277 31 Development Development NNP cord-005453-4057qib7 3277 32 , , , cord-005453-4057qib7 3277 33 AMED AMED NNP cord-005453-4057qib7 3277 34 . . . cord-005453-4057qib7 3278 1 High high JJ cord-005453-4057qib7 3278 2 incidence incidence NN cord-005453-4057qib7 3278 3 but but CC cord-005453-4057qib7 3278 4 low low JJ cord-005453-4057qib7 3278 5 mortality mortality NN cord-005453-4057qib7 3278 6 of of IN cord-005453-4057qib7 3278 7 EBV EBV NNP cord-005453-4057qib7 3278 8 related relate VBN cord-005453-4057qib7 3278 9 PTLD PTLD NNP cord-005453-4057qib7 3278 10 after after IN cord-005453-4057qib7 3278 11 T t NN cord-005453-4057qib7 3278 12 - - HYPH cord-005453-4057qib7 3278 13 cell cell NN cord-005453-4057qib7 3278 14 replete replete JJ cord-005453-4057qib7 3278 15 allo allo NN cord-005453-4057qib7 3278 16 - - HYPH cord-005453-4057qib7 3278 17 peripheral peripheral JJ cord-005453-4057qib7 3278 18 blood blood NN cord-005453-4057qib7 3278 19 HCT hct NN cord-005453-4057qib7 3278 20 with with IN cord-005453-4057qib7 3278 21 aggressive aggressive JJ cord-005453-4057qib7 3278 22 monitoring monitoring NN cord-005453-4057qib7 3278 23 and and CC cord-005453-4057qib7 3278 24 without without IN cord-005453-4057qib7 3278 25 pre pre JJ cord-005453-4057qib7 3278 26 - - JJ cord-005453-4057qib7 3278 27 emptive emptive JJ cord-005453-4057qib7 3278 28 rituximab rituximab NNP cord-005453-4057qib7 3278 29 Background Background NNP cord-005453-4057qib7 3278 30 : : : cord-005453-4057qib7 3279 1 The the DT cord-005453-4057qib7 3279 2 aim aim NN cord-005453-4057qib7 3279 3 of of IN cord-005453-4057qib7 3279 4 the the DT cord-005453-4057qib7 3279 5 study study NN cord-005453-4057qib7 3279 6 is be VBZ cord-005453-4057qib7 3279 7 to to TO cord-005453-4057qib7 3279 8 report report VB cord-005453-4057qib7 3279 9 the the DT cord-005453-4057qib7 3279 10 incidence incidence NN cord-005453-4057qib7 3279 11 and and CC cord-005453-4057qib7 3279 12 outcome outcome NN cord-005453-4057qib7 3279 13 of of IN cord-005453-4057qib7 3279 14 post post JJ cord-005453-4057qib7 3279 15 - - JJ cord-005453-4057qib7 3279 16 transplant transplant JJ cord-005453-4057qib7 3279 17 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 3279 18 disorder disorder NN cord-005453-4057qib7 3279 19 ( ( -LRB- cord-005453-4057qib7 3279 20 PTLD PTLD NNP cord-005453-4057qib7 3279 21 ) ) -RRB- cord-005453-4057qib7 3279 22 in in IN cord-005453-4057qib7 3279 23 the the DT cord-005453-4057qib7 3279 24 setting setting NN cord-005453-4057qib7 3279 25 of of IN cord-005453-4057qib7 3279 26 allogeneic allogeneic JJ cord-005453-4057qib7 3279 27 peripheral peripheral JJ cord-005453-4057qib7 3279 28 blood blood NN cord-005453-4057qib7 3279 29 hematopoietic hematopoietic JJ cord-005453-4057qib7 3279 30 stem stem NN cord-005453-4057qib7 3279 31 cell cell NN cord-005453-4057qib7 3279 32 transplantation transplantation NN cord-005453-4057qib7 3279 33 ( ( -LRB- cord-005453-4057qib7 3279 34 allo allo NN cord-005453-4057qib7 3279 35 - - HYPH cord-005453-4057qib7 3279 36 HSCT HSCT NNP cord-005453-4057qib7 3279 37 ) ) -RRB- cord-005453-4057qib7 3280 1 combining combine VBG cord-005453-4057qib7 3280 2 post post JJ cord-005453-4057qib7 3280 3 - - JJ cord-005453-4057qib7 3280 4 transplant transplant NN cord-005453-4057qib7 3280 5 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 3280 6 ( ( -LRB- cord-005453-4057qib7 3280 7 PTCy PTCy NNP cord-005453-4057qib7 3280 8 ) ) -RRB- cord-005453-4057qib7 3280 9 and and CC cord-005453-4057qib7 3280 10 anti anti JJ cord-005453-4057qib7 3280 11 - - JJ cord-005453-4057qib7 3280 12 thymocyte thymocyte JJ cord-005453-4057qib7 3280 13 globulin globulin NN cord-005453-4057qib7 3280 14 ( ( -LRB- cord-005453-4057qib7 3280 15 ATG ATG NNP cord-005453-4057qib7 3280 16 ) ) -RRB- cord-005453-4057qib7 3280 17 as as IN cord-005453-4057qib7 3280 18 graft graft NN cord-005453-4057qib7 3280 19 versus versus IN cord-005453-4057qib7 3280 20 host host NN cord-005453-4057qib7 3280 21 disease disease NN cord-005453-4057qib7 3280 22 ( ( -LRB- cord-005453-4057qib7 3280 23 GVHD GVHD NNP cord-005453-4057qib7 3280 24 ) ) -RRB- cord-005453-4057qib7 3280 25 prophylaxis prophylaxis NN cord-005453-4057qib7 3280 26 . . . cord-005453-4057qib7 3281 1 Methods method NNS cord-005453-4057qib7 3281 2 : : : cord-005453-4057qib7 3281 3 Between between IN cord-005453-4057qib7 3281 4 October October NNP cord-005453-4057qib7 3281 5 2015 2015 CD cord-005453-4057qib7 3281 6 and and CC cord-005453-4057qib7 3281 7 May May NNP cord-005453-4057qib7 3281 8 2018 2018 CD cord-005453-4057qib7 3281 9 , , , cord-005453-4057qib7 3281 10 195 195 CD cord-005453-4057qib7 3281 11 adult adult NN cord-005453-4057qib7 3281 12 patients patient NNS cord-005453-4057qib7 3281 13 diagnosed diagnose VBN cord-005453-4057qib7 3281 14 with with IN cord-005453-4057qib7 3281 15 hematological hematological JJ cord-005453-4057qib7 3281 16 malignancies malignancy NNS cord-005453-4057qib7 3281 17 underwent undergo VBD cord-005453-4057qib7 3281 18 a a DT cord-005453-4057qib7 3281 19 first first JJ cord-005453-4057qib7 3281 20 T t NN cord-005453-4057qib7 3281 21 - - HYPH cord-005453-4057qib7 3281 22 cell cell NN cord-005453-4057qib7 3281 23 replete replete JJ cord-005453-4057qib7 3281 24 allo allo NN cord-005453-4057qib7 3281 25 - - HYPH cord-005453-4057qib7 3281 26 HSCT HSCT NNP cord-005453-4057qib7 3281 27 in in IN cord-005453-4057qib7 3281 28 our -PRON- PRP$ cord-005453-4057qib7 3281 29 center center NN cord-005453-4057qib7 3281 30 . . . cord-005453-4057qib7 3282 1 All all DT cord-005453-4057qib7 3282 2 patients patient NNS cord-005453-4057qib7 3282 3 received receive VBD cord-005453-4057qib7 3282 4 a a DT cord-005453-4057qib7 3282 5 reduced reduce VBN cord-005453-4057qib7 3282 6 intensity intensity NN cord-005453-4057qib7 3282 7 conditioning conditioning NN cord-005453-4057qib7 3282 8 regimen regimen NN cord-005453-4057qib7 3282 9 with with IN cord-005453-4057qib7 3282 10 fludarabine fludarabine NN cord-005453-4057qib7 3282 11 , , , cord-005453-4057qib7 3282 12 busulfan busulfan NN cord-005453-4057qib7 3282 13 , , , cord-005453-4057qib7 3282 14 and and CC cord-005453-4057qib7 3282 15 200cGy 200cgy CD cord-005453-4057qib7 3282 16 of of IN cord-005453-4057qib7 3282 17 total total JJ cord-005453-4057qib7 3282 18 body body NN cord-005453-4057qib7 3282 19 irradiation irradiation NN cord-005453-4057qib7 3282 20 , , , cord-005453-4057qib7 3282 21 combined combine VBN cord-005453-4057qib7 3282 22 with with IN cord-005453-4057qib7 3282 23 rabbit rabbit NN cord-005453-4057qib7 3282 24 - - HYPH cord-005453-4057qib7 3282 25 ATG ATG NNP cord-005453-4057qib7 3282 26 , , , cord-005453-4057qib7 3282 27 PTCy PTCy NNS cord-005453-4057qib7 3282 28 and and CC cord-005453-4057qib7 3282 29 cyclosporine cyclosporine NN cord-005453-4057qib7 3282 30 ( ( -LRB- cord-005453-4057qib7 3282 31 CsA CsA NNP cord-005453-4057qib7 3282 32 ) ) -RRB- cord-005453-4057qib7 3282 33 . . . cord-005453-4057qib7 3283 1 EBV EBV NNP cord-005453-4057qib7 3283 2 titres titre NNS cord-005453-4057qib7 3283 3 were be VBD cord-005453-4057qib7 3283 4 monitored monitor VBN cord-005453-4057qib7 3283 5 weekly weekly RB cord-005453-4057qib7 3283 6 by by IN cord-005453-4057qib7 3283 7 quantitative quantitative JJ cord-005453-4057qib7 3283 8 PCR PCR NNP cord-005453-4057qib7 3283 9 in in IN cord-005453-4057qib7 3283 10 plasma plasma NN cord-005453-4057qib7 3283 11 samples sample NNS cord-005453-4057qib7 3283 12 . . . cord-005453-4057qib7 3284 1 The the DT cord-005453-4057qib7 3284 2 cut cut VB cord-005453-4057qib7 3284 3 - - HYPH cord-005453-4057qib7 3284 4 off off RP cord-005453-4057qib7 3284 5 value value NN cord-005453-4057qib7 3284 6 for for IN cord-005453-4057qib7 3284 7 test test NN cord-005453-4057qib7 3284 8 positivity positivity NN cord-005453-4057qib7 3284 9 was be VBD cord-005453-4057qib7 3284 10 > > XX cord-005453-4057qib7 3284 11 600 600 CD cord-005453-4057qib7 3284 12 copies copy NNS cord-005453-4057qib7 3284 13 of of IN cord-005453-4057qib7 3284 14 EBV EBV NNP cord-005453-4057qib7 3284 15 DNA DNA NNP cord-005453-4057qib7 3284 16 / / SYM cord-005453-4057qib7 3284 17 ml ml NNS cord-005453-4057qib7 3284 18 of of IN cord-005453-4057qib7 3284 19 plasma plasma NN cord-005453-4057qib7 3284 20 . . . cord-005453-4057qib7 3285 1 Last last JJ cord-005453-4057qib7 3285 2 follow follow NN cord-005453-4057qib7 3285 3 up up RP cord-005453-4057qib7 3285 4 was be VBD cord-005453-4057qib7 3285 5 November November NNP cord-005453-4057qib7 3285 6 2018 2018 CD cord-005453-4057qib7 3285 7 . . . cord-005453-4057qib7 3286 1 Median median JJ cord-005453-4057qib7 3286 2 follow follow VBP cord-005453-4057qib7 3286 3 up up RP cord-005453-4057qib7 3286 4 for for IN cord-005453-4057qib7 3286 5 patients patient NNS cord-005453-4057qib7 3286 6 known know VBN cord-005453-4057qib7 3286 7 to to TO cord-005453-4057qib7 3286 8 be be VB cord-005453-4057qib7 3286 9 alive alive JJ cord-005453-4057qib7 3286 10 was be VBD cord-005453-4057qib7 3286 11 19 19 CD cord-005453-4057qib7 3286 12 months month NNS cord-005453-4057qib7 3287 1 ( ( -LRB- cord-005453-4057qib7 3287 2 range range NNP cord-005453-4057qib7 3287 3 5 5 CD cord-005453-4057qib7 3287 4 - - SYM cord-005453-4057qib7 3287 5 35 35 CD cord-005453-4057qib7 3287 6 ) ) -RRB- cord-005453-4057qib7 3287 7 . . . cord-005453-4057qib7 3288 1 Results result NNS cord-005453-4057qib7 3288 2 : : : cord-005453-4057qib7 3289 1 Patient patient JJ cord-005453-4057qib7 3289 2 information information NN cord-005453-4057qib7 3289 3 is be VBZ cord-005453-4057qib7 3289 4 summarized summarize VBN cord-005453-4057qib7 3289 5 in in IN cord-005453-4057qib7 3289 6 Table Table NNP cord-005453-4057qib7 3289 7 1 1 CD cord-005453-4057qib7 3289 8 . . . cord-005453-4057qib7 3290 1 EBV EBV NNP cord-005453-4057qib7 3290 2 reactivation reactivation NN cord-005453-4057qib7 3290 3 was be VBD cord-005453-4057qib7 3290 4 documented document VBN cord-005453-4057qib7 3290 5 in in IN cord-005453-4057qib7 3290 6 117 117 CD cord-005453-4057qib7 3290 7 ( ( -LRB- cord-005453-4057qib7 3290 8 60 60 CD cord-005453-4057qib7 3290 9 % % NN cord-005453-4057qib7 3290 10 ) ) -RRB- cord-005453-4057qib7 3290 11 patients patient NNS cord-005453-4057qib7 3290 12 . . . cord-005453-4057qib7 3291 1 Median median JJ cord-005453-4057qib7 3291 2 time time NN cord-005453-4057qib7 3291 3 to to IN cord-005453-4057qib7 3291 4 EBV EBV NNP cord-005453-4057qib7 3291 5 reactivation reactivation NN cord-005453-4057qib7 3291 6 and and CC cord-005453-4057qib7 3291 7 the the DT cord-005453-4057qib7 3291 8 diagnosis diagnosis NN cord-005453-4057qib7 3291 9 of of IN cord-005453-4057qib7 3291 10 presumed presume VBN cord-005453-4057qib7 3291 11 / / SYM cord-005453-4057qib7 3291 12 proven prove VBN cord-005453-4057qib7 3292 1 ( ( -LRB- cord-005453-4057qib7 3292 2 P P NNP cord-005453-4057qib7 3292 3 / / SYM cord-005453-4057qib7 3292 4 P)-PTLD P)-PTLD NNP cord-005453-4057qib7 3292 5 were be VBD cord-005453-4057qib7 3292 6 75 75 CD cord-005453-4057qib7 3292 7 ( ( -LRB- cord-005453-4057qib7 3292 8 16 16 CD cord-005453-4057qib7 3292 9 - - SYM cord-005453-4057qib7 3292 10 326 326 CD cord-005453-4057qib7 3292 11 ) ) -RRB- cord-005453-4057qib7 3292 12 days day NNS cord-005453-4057qib7 3292 13 and and CC cord-005453-4057qib7 3292 14 97 97 CD cord-005453-4057qib7 3292 15 ( ( -LRB- cord-005453-4057qib7 3292 16 54 54 CD cord-005453-4057qib7 3292 17 - - SYM cord-005453-4057qib7 3292 18 306 306 CD cord-005453-4057qib7 3292 19 ) ) -RRB- cord-005453-4057qib7 3292 20 days day NNS cord-005453-4057qib7 3292 21 [ [ -LRB- cord-005453-4057qib7 3292 22 3 3 CD cord-005453-4057qib7 3292 23 ( ( -LRB- cord-005453-4057qib7 3292 24 0 0 CD cord-005453-4057qib7 3292 25 - - SYM cord-005453-4057qib7 3292 26 10 10 CD cord-005453-4057qib7 3292 27 ) ) -RRB- cord-005453-4057qib7 3292 28 months month NNS cord-005453-4057qib7 3292 29 ] ] -RRB- cord-005453-4057qib7 3292 30 , , , cord-005453-4057qib7 3292 31 respectively respectively RB cord-005453-4057qib7 3292 32 . . . cord-005453-4057qib7 3293 1 Median median JJ cord-005453-4057qib7 3293 2 time time NN cord-005453-4057qib7 3293 3 between between IN cord-005453-4057qib7 3293 4 first first JJ cord-005453-4057qib7 3293 5 EBV EBV NNP cord-005453-4057qib7 3293 6 reactivation reactivation NN cord-005453-4057qib7 3293 7 to to IN cord-005453-4057qib7 3293 8 P p NN cord-005453-4057qib7 3293 9 / / SYM cord-005453-4057qib7 3293 10 P p NN cord-005453-4057qib7 3293 11 - - HYPH cord-005453-4057qib7 3293 12 PTLD PTLD NNP cord-005453-4057qib7 3293 13 was be VBD cord-005453-4057qib7 3293 14 21 21 CD cord-005453-4057qib7 3293 15 ( ( -LRB- cord-005453-4057qib7 3293 16 0 0 CD cord-005453-4057qib7 3293 17 - - SYM cord-005453-4057qib7 3293 18 175 175 CD cord-005453-4057qib7 3293 19 ) ) -RRB- cord-005453-4057qib7 3293 20 days day NNS cord-005453-4057qib7 3293 21 . . . cord-005453-4057qib7 3294 1 Seventeen seventeen CD cord-005453-4057qib7 3294 2 ( ( -LRB- cord-005453-4057qib7 3294 3 14 14 CD cord-005453-4057qib7 3294 4 % % NN cord-005453-4057qib7 3294 5 ) ) -RRB- cord-005453-4057qib7 3294 6 of of IN cord-005453-4057qib7 3294 7 the the DT cord-005453-4057qib7 3294 8 117 117 CD cord-005453-4057qib7 3294 9 patients patient NNS cord-005453-4057qib7 3294 10 developed develop VBN cord-005453-4057qib7 3294 11 P p NN cord-005453-4057qib7 3294 12 / / SYM cord-005453-4057qib7 3294 13 P p NN cord-005453-4057qib7 3294 14 - - HYPH cord-005453-4057qib7 3294 15 PTLD PTLD NNP cord-005453-4057qib7 3294 16 . . . cord-005453-4057qib7 3295 1 Median median JJ cord-005453-4057qib7 3295 2 age age NN cord-005453-4057qib7 3295 3 was be VBD cord-005453-4057qib7 3295 4 55 55 CD cord-005453-4057qib7 3295 5 years year NNS cord-005453-4057qib7 3295 6 . . . cord-005453-4057qib7 3296 1 Two two CD cord-005453-4057qib7 3296 2 ( ( -LRB- cord-005453-4057qib7 3296 3 12 12 CD cord-005453-4057qib7 3296 4 % % NN cord-005453-4057qib7 3296 5 ) ) -RRB- cord-005453-4057qib7 3296 6 received receive VBD cord-005453-4057qib7 3296 7 MRD MRD NNP cord-005453-4057qib7 3296 8 , , , cord-005453-4057qib7 3296 9 9 9 CD cord-005453-4057qib7 3296 10 ( ( -LRB- cord-005453-4057qib7 3296 11 53 53 CD cord-005453-4057qib7 3296 12 % % NN cord-005453-4057qib7 3296 13 ) ) -RRB- cord-005453-4057qib7 3296 14 10/10 10/10 CD cord-005453-4057qib7 3296 15 MUD mud NN cord-005453-4057qib7 3296 16 , , , cord-005453-4057qib7 3296 17 1 1 CD cord-005453-4057qib7 3296 18 ( ( -LRB- cord-005453-4057qib7 3296 19 6 6 CD cord-005453-4057qib7 3296 20 % % NN cord-005453-4057qib7 3296 21 ) ) -RRB- cord-005453-4057qib7 3296 22 9/10 9/10 CD cord-005453-4057qib7 3296 23 MUD mud NN cord-005453-4057qib7 3296 24 , , , cord-005453-4057qib7 3296 25 and and CC cord-005453-4057qib7 3296 26 5 5 CD cord-005453-4057qib7 3296 27 ( ( -LRB- cord-005453-4057qib7 3296 28 29 29 CD cord-005453-4057qib7 3296 29 % % NN cord-005453-4057qib7 3296 30 ) ) -RRB- cord-005453-4057qib7 3296 31 haploidentical haploidentical JJ cord-005453-4057qib7 3296 32 donor donor NN cord-005453-4057qib7 3296 33 grafts graft NNS cord-005453-4057qib7 3296 34 . . . cord-005453-4057qib7 3297 1 Twelve twelve CD cord-005453-4057qib7 3297 2 ( ( -LRB- cord-005453-4057qib7 3297 3 71 71 CD cord-005453-4057qib7 3297 4 % % NN cord-005453-4057qib7 3297 5 ) ) -RRB- cord-005453-4057qib7 3297 6 were be VBD cord-005453-4057qib7 3297 7 on on IN cord-005453-4057qib7 3297 8 therapeutic therapeutic JJ cord-005453-4057qib7 3297 9 cyclosporine cyclosporine NN cord-005453-4057qib7 3297 10 at at IN cord-005453-4057qib7 3297 11 diagnosis diagnosis NN cord-005453-4057qib7 3297 12 . . . cord-005453-4057qib7 3298 1 Pre pre JJ cord-005453-4057qib7 3298 2 - - JJ cord-005453-4057qib7 3298 3 Emptive emptive JJ cord-005453-4057qib7 3298 4 therapy therapy NN cord-005453-4057qib7 3298 5 was be VBD cord-005453-4057qib7 3298 6 not not RB cord-005453-4057qib7 3298 7 given give VBN cord-005453-4057qib7 3298 8 to to IN cord-005453-4057qib7 3298 9 any any DT cord-005453-4057qib7 3298 10 case case NN cord-005453-4057qib7 3298 11 and and CC cord-005453-4057qib7 3298 12 only only RB cord-005453-4057qib7 3298 13 Probable probable JJ cord-005453-4057qib7 3298 14 or or CC cord-005453-4057qib7 3298 15 Proven Proven NNP cord-005453-4057qib7 3298 16 PTLD PTLD NNP cord-005453-4057qib7 3298 17 were be VBD cord-005453-4057qib7 3298 18 given give VBN cord-005453-4057qib7 3298 19 rituximab rituximab JJ cord-005453-4057qib7 3298 20 . . . cord-005453-4057qib7 3299 1 Treatment treatment NN cord-005453-4057qib7 3299 2 was be VBD cord-005453-4057qib7 3299 3 based base VBN cord-005453-4057qib7 3299 4 on on IN cord-005453-4057qib7 3299 5 reduction reduction NN cord-005453-4057qib7 3299 6 of of IN cord-005453-4057qib7 3299 7 the the DT cord-005453-4057qib7 3299 8 immunosuppression immunosuppression NN cord-005453-4057qib7 3299 9 in in IN cord-005453-4057qib7 3299 10 3 3 CD cord-005453-4057qib7 3299 11 patients patient NNS cord-005453-4057qib7 3299 12 and and CC cord-005453-4057qib7 3299 13 with with IN cord-005453-4057qib7 3299 14 the the DT cord-005453-4057qib7 3299 15 addition addition NN cord-005453-4057qib7 3299 16 of of IN cord-005453-4057qib7 3299 17 weekly weekly JJ cord-005453-4057qib7 3299 18 Rituximab Rituximab NNP cord-005453-4057qib7 3299 19 375 375 CD cord-005453-4057qib7 3299 20 mg/ mg/ NN cord-005453-4057qib7 3299 21 m m CD cord-005453-4057qib7 3299 22 2 2 CD cord-005453-4057qib7 3299 23 in in IN cord-005453-4057qib7 3299 24 15 15 CD cord-005453-4057qib7 3299 25 cases case NNS cord-005453-4057qib7 3299 26 . . . cord-005453-4057qib7 3300 1 Fifteen fifteen CD cord-005453-4057qib7 3300 2 ( ( -LRB- cord-005453-4057qib7 3300 3 88 88 CD cord-005453-4057qib7 3300 4 % % NN cord-005453-4057qib7 3300 5 ) ) -RRB- cord-005453-4057qib7 3300 6 achieved achieve VBN cord-005453-4057qib7 3300 7 complete complete JJ cord-005453-4057qib7 3300 8 clinical clinical JJ cord-005453-4057qib7 3300 9 responses response NNS cord-005453-4057qib7 3300 10 with with IN cord-005453-4057qib7 3300 11 PCR PCR NNP cord-005453-4057qib7 3300 12 negativity negativity NN cord-005453-4057qib7 3300 13 . . . cord-005453-4057qib7 3301 1 Two two CD cord-005453-4057qib7 3301 2 ( ( -LRB- cord-005453-4057qib7 3301 3 12 12 CD cord-005453-4057qib7 3301 4 % % NN cord-005453-4057qib7 3301 5 ) ) -RRB- cord-005453-4057qib7 3301 6 patients patient NNS cord-005453-4057qib7 3301 7 died die VBD cord-005453-4057qib7 3301 8 secondary secondary JJ cord-005453-4057qib7 3301 9 to to IN cord-005453-4057qib7 3301 10 PTLD PTLD NNP cord-005453-4057qib7 3301 11 . . . cord-005453-4057qib7 3302 1 Conclusions conclusion NNS cord-005453-4057qib7 3302 2 : : : cord-005453-4057qib7 3303 1 ATG ATG NNP cord-005453-4057qib7 3303 2 based base VBN cord-005453-4057qib7 3303 3 conditioning conditioning NN cord-005453-4057qib7 3303 4 is be VBZ cord-005453-4057qib7 3303 5 associated associate VBN cord-005453-4057qib7 3303 6 with with IN cord-005453-4057qib7 3303 7 increased increase VBN cord-005453-4057qib7 3303 8 viral viral JJ cord-005453-4057qib7 3303 9 reactivations reactivation NNS cord-005453-4057qib7 3303 10 . . . cord-005453-4057qib7 3304 1 Frequent frequent JJ cord-005453-4057qib7 3304 2 EBV EBV NNP cord-005453-4057qib7 3304 3 monitoring monitoring NN cord-005453-4057qib7 3304 4 and and CC cord-005453-4057qib7 3304 5 pre pre JJ cord-005453-4057qib7 3304 6 - - JJ cord-005453-4057qib7 3304 7 emptive emptive JJ cord-005453-4057qib7 3304 8 treatment treatment NN cord-005453-4057qib7 3304 9 may may MD cord-005453-4057qib7 3304 10 lead lead VB cord-005453-4057qib7 3304 11 to to IN cord-005453-4057qib7 3304 12 rapid rapid JJ cord-005453-4057qib7 3304 13 disease disease NN cord-005453-4057qib7 3304 14 control control NN cord-005453-4057qib7 3304 15 . . . cord-005453-4057qib7 3305 1 Further further JJ cord-005453-4057qib7 3305 2 research research NN cord-005453-4057qib7 3305 3 is be VBZ cord-005453-4057qib7 3305 4 required require VBN cord-005453-4057qib7 3305 5 to to TO cord-005453-4057qib7 3305 6 optimize optimize VB cord-005453-4057qib7 3305 7 monitoring monitoring NN cord-005453-4057qib7 3305 8 and and CC cord-005453-4057qib7 3305 9 management management NN cord-005453-4057qib7 3305 10 strategies strategy NNS cord-005453-4057qib7 3305 11 in in IN cord-005453-4057qib7 3305 12 allo allo NN cord-005453-4057qib7 3305 13 - - HYPH cord-005453-4057qib7 3305 14 HSCT HSCT NNP cord-005453-4057qib7 3305 15 recipients recipient NNS cord-005453-4057qib7 3305 16 . . . cord-005453-4057qib7 3306 1 Disclosure disclosure NN cord-005453-4057qib7 3306 2 : : : cord-005453-4057qib7 3306 3 Nothing nothing NN cord-005453-4057qib7 3306 4 to to TO cord-005453-4057qib7 3306 5 declare declare VB cord-005453-4057qib7 3306 6 P160 P160 NNP cord-005453-4057qib7 3306 7 Acoustically acoustically RB cord-005453-4057qib7 3306 8 enriched enrich VBN cord-005453-4057qib7 3306 9 extracellular extracellular JJ cord-005453-4057qib7 3306 10 vesicles vesicle NNS cord-005453-4057qib7 3306 11 as as IN cord-005453-4057qib7 3306 12 potential potential JJ cord-005453-4057qib7 3306 13 markers marker NNS cord-005453-4057qib7 3306 14 for for IN cord-005453-4057qib7 3306 15 allogeneic allogeneic JJ cord-005453-4057qib7 3306 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 3306 17 stem stem NN cord-005453-4057qib7 3306 18 cell cell NN cord-005453-4057qib7 3306 19 transplantation transplantation NN cord-005453-4057qib7 3306 20 complications complication NNS cord-005453-4057qib7 3306 21 Hooi Hooi NNP cord-005453-4057qib7 3306 22 - - HYPH cord-005453-4057qib7 3306 23 Ching Ching NNP cord-005453-4057qib7 3306 24 Lim Lim NNP cord-005453-4057qib7 3306 25 1 1 CD cord-005453-4057qib7 3306 26 , , , cord-005453-4057qib7 3306 27 Robert Robert NNP cord-005453-4057qib7 3306 28 Palmason Palmason NNP cord-005453-4057qib7 3306 29 2 2 CD cord-005453-4057qib7 3306 30 , , , cord-005453-4057qib7 3306 31 Stig Stig NNP cord-005453-4057qib7 3306 32 Lenhoff Lenhoff NNP cord-005453-4057qib7 3306 33 2 2 CD cord-005453-4057qib7 3306 34 , , , cord-005453-4057qib7 3306 35 Thomas Thomas NNP cord-005453-4057qib7 3306 36 Laurell Laurell NNP cord-005453-4057qib7 3306 37 1 1 CD cord-005453-4057qib7 3306 38 , , , cord-005453-4057qib7 3306 39 Stefan Stefan NNP cord-005453-4057qib7 3306 40 Scheding Scheding NNP cord-005453-4057qib7 3307 1 1,2 1,2 LS cord-005453-4057qib7 3307 2 Background background NN cord-005453-4057qib7 3307 3 : : : cord-005453-4057qib7 3308 1 Extracellular Extracellular NNP cord-005453-4057qib7 3308 2 vesicles vesicle NNS cord-005453-4057qib7 3308 3 ( ( -LRB- cord-005453-4057qib7 3308 4 EVs ev NNS cord-005453-4057qib7 3308 5 ) ) -RRB- cord-005453-4057qib7 3308 6 contain contain VBP cord-005453-4057qib7 3308 7 a a DT cord-005453-4057qib7 3308 8 number number NN cord-005453-4057qib7 3308 9 of of IN cord-005453-4057qib7 3308 10 condition condition NN cord-005453-4057qib7 3308 11 - - HYPH cord-005453-4057qib7 3308 12 specific specific JJ cord-005453-4057qib7 3308 13 proteins protein NNS cord-005453-4057qib7 3308 14 , , , cord-005453-4057qib7 3308 15 DNA DNA NNP cord-005453-4057qib7 3308 16 and and CC cord-005453-4057qib7 3308 17 RNA RNA NNP cord-005453-4057qib7 3308 18 types type NNS cord-005453-4057qib7 3308 19 and and CC cord-005453-4057qib7 3308 20 might may MD cord-005453-4057qib7 3308 21 therefore therefore RB cord-005453-4057qib7 3308 22 be be VB cord-005453-4057qib7 3308 23 used use VBN cord-005453-4057qib7 3308 24 for for IN cord-005453-4057qib7 3308 25 the the DT cord-005453-4057qib7 3308 26 early early JJ cord-005453-4057qib7 3308 27 detection detection NN cord-005453-4057qib7 3308 28 of of IN cord-005453-4057qib7 3308 29 posttransplant posttransplant NN cord-005453-4057qib7 3308 30 complications complication NNS cord-005453-4057qib7 3308 31 . . . cord-005453-4057qib7 3309 1 However however RB cord-005453-4057qib7 3309 2 , , , cord-005453-4057qib7 3309 3 traditional traditional JJ cord-005453-4057qib7 3309 4 EV ev NN cord-005453-4057qib7 3309 5 isolation isolation NN cord-005453-4057qib7 3309 6 ( ( -LRB- cord-005453-4057qib7 3309 7 ultracentrifugation ultracentrifugation NN cord-005453-4057qib7 3309 8 ) ) -RRB- cord-005453-4057qib7 3309 9 is be VBZ cord-005453-4057qib7 3309 10 time time NN cord-005453-4057qib7 3309 11 consuming consume VBG cord-005453-4057qib7 3309 12 and and CC cord-005453-4057qib7 3309 13 requires require VBZ cord-005453-4057qib7 3309 14 large large JJ cord-005453-4057qib7 3309 15 sample sample NN cord-005453-4057qib7 3309 16 volumes volume NNS cord-005453-4057qib7 3309 17 thus thus RB cord-005453-4057qib7 3309 18 making make VBG cord-005453-4057qib7 3309 19 it -PRON- PRP cord-005453-4057qib7 3309 20 difficult difficult JJ cord-005453-4057qib7 3309 21 to to TO cord-005453-4057qib7 3309 22 perform perform VB cord-005453-4057qib7 3309 23 longitudinal longitudinal JJ cord-005453-4057qib7 3309 24 studies study NNS cord-005453-4057qib7 3309 25 on on IN cord-005453-4057qib7 3309 26 larger large JJR cord-005453-4057qib7 3309 27 patient patient JJ cord-005453-4057qib7 3309 28 cohorts cohort NNS cord-005453-4057qib7 3309 29 . . . cord-005453-4057qib7 3310 1 We -PRON- PRP cord-005453-4057qib7 3310 2 therefore therefore RB cord-005453-4057qib7 3310 3 investigated investigate VBD cord-005453-4057qib7 3310 4 whether whether IN cord-005453-4057qib7 3310 5 recently recently RB cord-005453-4057qib7 3310 6 - - HYPH cord-005453-4057qib7 3310 7 developed develop VBN cord-005453-4057qib7 3310 8 acoustic acoustic JJ cord-005453-4057qib7 3310 9 trapping trapping NN cord-005453-4057qib7 3310 10 could could MD cord-005453-4057qib7 3310 11 be be VB cord-005453-4057qib7 3310 12 applied apply VBN cord-005453-4057qib7 3310 13 to to TO cord-005453-4057qib7 3310 14 isolate isolate VB cord-005453-4057qib7 3310 15 EVs ev NNS cord-005453-4057qib7 3310 16 from from IN cord-005453-4057qib7 3310 17 patient patient JJ cord-005453-4057qib7 3310 18 plasma plasma NN cord-005453-4057qib7 3310 19 for for IN cord-005453-4057qib7 3310 20 biomarker biomarker NN cord-005453-4057qib7 3310 21 development development NN cord-005453-4057qib7 3310 22 . . . cord-005453-4057qib7 3311 1 Methods method NNS cord-005453-4057qib7 3311 2 : : : cord-005453-4057qib7 3311 3 Plasma plasma NN cord-005453-4057qib7 3311 4 samples sample NNS cord-005453-4057qib7 3311 5 were be VBD cord-005453-4057qib7 3311 6 collected collect VBN cord-005453-4057qib7 3311 7 from from IN cord-005453-4057qib7 3311 8 10 10 CD cord-005453-4057qib7 3311 9 consecutive consecutive JJ cord-005453-4057qib7 3311 10 patients patient NNS cord-005453-4057qib7 3311 11 before before RB cord-005453-4057qib7 3311 12 and and CC cord-005453-4057qib7 3311 13 up up IN cord-005453-4057qib7 3311 14 to to TO cord-005453-4057qib7 3311 15 3 3 CD cord-005453-4057qib7 3311 16 months month NNS cord-005453-4057qib7 3311 17 after after IN cord-005453-4057qib7 3311 18 allogeneic allogeneic NN cord-005453-4057qib7 3311 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 3311 20 stem stem NN cord-005453-4057qib7 3311 21 cell cell NN cord-005453-4057qib7 3311 22 transplantation transplantation NN cord-005453-4057qib7 3311 23 . . . cord-005453-4057qib7 3312 1 Patients patient NNS cord-005453-4057qib7 3312 2 ( ( -LRB- cord-005453-4057qib7 3312 3 age age NN cord-005453-4057qib7 3312 4 : : : cord-005453-4057qib7 3312 5 22 22 CD cord-005453-4057qib7 3312 6 - - SYM cord-005453-4057qib7 3312 7 58 58 CD cord-005453-4057qib7 3312 8 years year NNS cord-005453-4057qib7 3312 9 ) ) -RRB- cord-005453-4057qib7 3312 10 with with IN cord-005453-4057qib7 3312 11 high high JJ cord-005453-4057qib7 3312 12 - - HYPH cord-005453-4057qib7 3312 13 risk risk NN cord-005453-4057qib7 3312 14 or or CC cord-005453-4057qib7 3312 15 refractory refractory JJ cord-005453-4057qib7 3312 16 / / SYM cord-005453-4057qib7 3312 17 relapsed relapse VBN cord-005453-4057qib7 3312 18 diseases disease NNS cord-005453-4057qib7 3312 19 were be VBD cord-005453-4057qib7 3312 20 transplanted transplant VBN cord-005453-4057qib7 3312 21 with with IN cord-005453-4057qib7 3312 22 mobilized mobilize VBN cord-005453-4057qib7 3312 23 PBSC PBSC NNP cord-005453-4057qib7 3312 24 from from IN cord-005453-4057qib7 3312 25 related related JJ cord-005453-4057qib7 3312 26 ( ( -LRB- cord-005453-4057qib7 3312 27 n=2 n=2 NNS cord-005453-4057qib7 3312 28 ) ) -RRB- cord-005453-4057qib7 3312 29 and and CC cord-005453-4057qib7 3312 30 unrelated unrelated JJ cord-005453-4057qib7 3312 31 donors donor NNS cord-005453-4057qib7 3312 32 ( ( -LRB- cord-005453-4057qib7 3312 33 n=8 n=8 NN cord-005453-4057qib7 3312 34 ) ) -RRB- cord-005453-4057qib7 3312 35 after after IN cord-005453-4057qib7 3312 36 standard standard JJ cord-005453-4057qib7 3312 37 conditioning conditioning NN cord-005453-4057qib7 3312 38 . . . cord-005453-4057qib7 3313 1 GvHD GvHD NNP cord-005453-4057qib7 3313 2 prophylaxis prophylaxis NN cord-005453-4057qib7 3313 3 was be VBD cord-005453-4057qib7 3313 4 cyclosporine cyclosporine JJ cord-005453-4057qib7 3313 5 and and CC cord-005453-4057qib7 3313 6 methotrexate methotrexate NNP cord-005453-4057qib7 3313 7 . . . cord-005453-4057qib7 3314 1 Plasma plasma NN cord-005453-4057qib7 3314 2 samples sample NNS cord-005453-4057qib7 3314 3 were be VBD cord-005453-4057qib7 3314 4 frozen freeze VBN cord-005453-4057qib7 3314 5 and and CC cord-005453-4057qib7 3314 6 thawed thaw VBN cord-005453-4057qib7 3314 7 for for IN cord-005453-4057qib7 3314 8 EV ev NN cord-005453-4057qib7 3314 9 enrichment enrichment NN cord-005453-4057qib7 3314 10 using use VBG cord-005453-4057qib7 3314 11 a a DT cord-005453-4057qib7 3314 12 novel novel JJ cord-005453-4057qib7 3314 13 acoustofluidic acoustofluidic NN cord-005453-4057qib7 3314 14 - - HYPH cord-005453-4057qib7 3314 15 based base VBN cord-005453-4057qib7 3314 16 technology technology NN cord-005453-4057qib7 3314 17 ( ( -LRB- cord-005453-4057qib7 3314 18 acoustic acoustic JJ cord-005453-4057qib7 3314 19 trapping trapping NN cord-005453-4057qib7 3314 20 ) ) -RRB- cord-005453-4057qib7 3314 21 . . . cord-005453-4057qib7 3315 1 Acoustic acoustic JJ cord-005453-4057qib7 3315 2 trapping trapping NN cord-005453-4057qib7 3315 3 uses use VBZ cord-005453-4057qib7 3315 4 ultrasound ultrasound NN cord-005453-4057qib7 3315 5 as as IN cord-005453-4057qib7 3315 6 a a DT cord-005453-4057qib7 3315 7 local local JJ cord-005453-4057qib7 3315 8 λ/2 λ/2 NN cord-005453-4057qib7 3315 9 acoustic acoustic JJ cord-005453-4057qib7 3315 10 standing standing NN cord-005453-4057qib7 3315 11 wave wave NN cord-005453-4057qib7 3315 12 produced produce VBN cord-005453-4057qib7 3315 13 by by IN cord-005453-4057qib7 3315 14 a a DT cord-005453-4057qib7 3315 15 piezoelectric piezoelectric JJ cord-005453-4057qib7 3315 16 transducer transducer NN cord-005453-4057qib7 3315 17 over over IN cord-005453-4057qib7 3315 18 a a DT cord-005453-4057qib7 3315 19 capillary capillary NN cord-005453-4057qib7 3315 20 . . . cord-005453-4057qib7 3316 1 First first RB cord-005453-4057qib7 3316 2 , , , cord-005453-4057qib7 3316 3 12 12 CD cord-005453-4057qib7 3316 4 μm μm NN cord-005453-4057qib7 3316 5 polystyrene polystyrene NN cord-005453-4057qib7 3316 6 beads bead NNS cord-005453-4057qib7 3316 7 are be VBP cord-005453-4057qib7 3316 8 captured capture VBN cord-005453-4057qib7 3316 9 which which WDT cord-005453-4057qib7 3316 10 serve serve VBP cord-005453-4057qib7 3316 11 as as IN cord-005453-4057qib7 3316 12 seeding seed VBG cord-005453-4057qib7 3316 13 particles particle NNS cord-005453-4057qib7 3316 14 . . . cord-005453-4057qib7 3317 1 After after IN cord-005453-4057qib7 3317 2 washing washing NN cord-005453-4057qib7 3317 3 , , , cord-005453-4057qib7 3317 4 target target NN cord-005453-4057qib7 3317 5 particles particle NNS cord-005453-4057qib7 3317 6 ( ( -LRB- cord-005453-4057qib7 3317 7 EVs ev NNS cord-005453-4057qib7 3317 8 ) ) -RRB- cord-005453-4057qib7 3317 9 are be VBP cord-005453-4057qib7 3317 10 then then RB cord-005453-4057qib7 3317 11 captured capture VBN cord-005453-4057qib7 3317 12 ( ( -LRB- cord-005453-4057qib7 3317 13 " " `` cord-005453-4057qib7 3317 14 trapped trap VBN cord-005453-4057qib7 3317 15 " " '' cord-005453-4057qib7 3317 16 ) ) -RRB- cord-005453-4057qib7 3317 17 in in IN cord-005453-4057qib7 3317 18 the the DT cord-005453-4057qib7 3317 19 acoustic acoustic JJ cord-005453-4057qib7 3317 20 field field NN cord-005453-4057qib7 3317 21 . . . cord-005453-4057qib7 3318 1 A a DT cord-005453-4057qib7 3318 2 semi semi JJ cord-005453-4057qib7 3318 3 - - JJ cord-005453-4057qib7 3318 4 automatic automatic JJ cord-005453-4057qib7 3318 5 trapping trapping NN cord-005453-4057qib7 3318 6 device device NN cord-005453-4057qib7 3318 7 ( ( -LRB- cord-005453-4057qib7 3318 8 AcouTrap AcouTrap NNP cord-005453-4057qib7 3318 9 ) ) -RRB- cord-005453-4057qib7 3318 10 was be VBD cord-005453-4057qib7 3318 11 used use VBN cord-005453-4057qib7 3318 12 to to TO cord-005453-4057qib7 3318 13 isolate isolate VB cord-005453-4057qib7 3318 14 EVs ev NNS cord-005453-4057qib7 3318 15 from from IN cord-005453-4057qib7 3318 16 diluted diluted JJ cord-005453-4057qib7 3318 17 plasma plasma NN cord-005453-4057qib7 3318 18 ( ( -LRB- cord-005453-4057qib7 3318 19 1:2 1:2 CD cord-005453-4057qib7 3318 20 in in IN cord-005453-4057qib7 3318 21 PBS PBS NNP cord-005453-4057qib7 3318 22 ) ) -RRB- cord-005453-4057qib7 3318 23 . . . cord-005453-4057qib7 3319 1 The the DT cord-005453-4057qib7 3319 2 number number NN cord-005453-4057qib7 3319 3 of of IN cord-005453-4057qib7 3319 4 EVs ev NNS cord-005453-4057qib7 3319 5 and and CC cord-005453-4057qib7 3319 6 size size NN cord-005453-4057qib7 3319 7 distribution distribution NN cord-005453-4057qib7 3319 8 were be VBD cord-005453-4057qib7 3319 9 analyzed analyze VBN cord-005453-4057qib7 3319 10 by by IN cord-005453-4057qib7 3319 11 nanoparticle nanoparticle NN cord-005453-4057qib7 3319 12 tracking tracking NN cord-005453-4057qib7 3319 13 analysis analysis NN cord-005453-4057qib7 3319 14 . . . cord-005453-4057qib7 3320 1 miRNA miRNA NNP cord-005453-4057qib7 3320 2 analysis analysis NN cord-005453-4057qib7 3320 3 was be VBD cord-005453-4057qib7 3320 4 performed perform VBN cord-005453-4057qib7 3320 5 by by IN cord-005453-4057qib7 3320 6 qPCR.EVs qpcr.ev NNS cord-005453-4057qib7 3320 7 were be VBD cord-005453-4057qib7 3320 8 enriched enrich VBN cord-005453-4057qib7 3320 9 in in IN cord-005453-4057qib7 3320 10 duplicate duplicate NN cord-005453-4057qib7 3320 11 from from IN cord-005453-4057qib7 3320 12 50μl 50μl NN cord-005453-4057qib7 3320 13 and and CC cord-005453-4057qib7 3320 14 300μl 300μl NN cord-005453-4057qib7 3320 15 of of IN cord-005453-4057qib7 3320 16 diluted diluted JJ cord-005453-4057qib7 3320 17 plasma plasma NN cord-005453-4057qib7 3320 18 for for IN cord-005453-4057qib7 3320 19 nanoparticle nanoparticle NN cord-005453-4057qib7 3320 20 tracking tracking NN cord-005453-4057qib7 3320 21 analysis analysis NN cord-005453-4057qib7 3320 22 and and CC cord-005453-4057qib7 3320 23 qPCR qPCR NNP cord-005453-4057qib7 3320 24 analysis analysis NNP cord-005453-4057qib7 3320 25 , , , cord-005453-4057qib7 3320 26 respectively respectively RB cord-005453-4057qib7 3320 27 . . . cord-005453-4057qib7 3321 1 Results result NNS cord-005453-4057qib7 3321 2 : : : cord-005453-4057qib7 3322 1 EVs ev NNS cord-005453-4057qib7 3322 2 were be VBD cord-005453-4057qib7 3322 3 successfully successfully RB cord-005453-4057qib7 3322 4 isolated isolate VBN cord-005453-4057qib7 3322 5 from from IN cord-005453-4057qib7 3322 6 all all DT cord-005453-4057qib7 3322 7 plasma plasma NN cord-005453-4057qib7 3322 8 samples sample NNS cord-005453-4057qib7 3322 9 . . . cord-005453-4057qib7 3323 1 A a DT cord-005453-4057qib7 3323 2 total total NN cord-005453-4057qib7 3323 3 of of IN cord-005453-4057qib7 3323 4 89 89 CD cord-005453-4057qib7 3323 5 plasma plasma NN cord-005453-4057qib7 3323 6 samples sample NNS cord-005453-4057qib7 3323 7 were be VBD cord-005453-4057qib7 3323 8 processed process VBN cord-005453-4057qib7 3323 9 . . . cord-005453-4057qib7 3324 1 Numbers number NNS cord-005453-4057qib7 3324 2 of of IN cord-005453-4057qib7 3324 3 trapped trap VBN cord-005453-4057qib7 3324 4 EVs ev NNS cord-005453-4057qib7 3324 5 ranged range VBD cord-005453-4057qib7 3324 6 from from IN cord-005453-4057qib7 3324 7 3.7x10 3.7x10 CD cord-005453-4057qib7 3324 8 8 8 CD cord-005453-4057qib7 3324 9 -5.5x10 -5.5x10 NNP cord-005453-4057qib7 3324 10 9 9 CD cord-005453-4057qib7 3324 11 before before IN cord-005453-4057qib7 3324 12 conditioning conditioning NN cord-005453-4057qib7 3324 13 to to IN cord-005453-4057qib7 3324 14 4.4x10 4.4x10 CD cord-005453-4057qib7 3324 15 8 8 CD cord-005453-4057qib7 3324 16 -1.5x10 -1.5x10 CD cord-005453-4057qib7 3324 17 10 10 CD cord-005453-4057qib7 3324 18 per per IN cord-005453-4057qib7 3324 19 50μl 50μl JJ cord-005453-4057qib7 3324 20 diluted diluted JJ cord-005453-4057qib7 3324 21 plasma plasma NN cord-005453-4057qib7 3324 22 after after IN cord-005453-4057qib7 3324 23 transplantation transplantation NN cord-005453-4057qib7 3324 24 . . . cord-005453-4057qib7 3325 1 The the DT cord-005453-4057qib7 3325 2 maximum maximum JJ cord-005453-4057qib7 3325 3 change change NN cord-005453-4057qib7 3325 4 in in IN cord-005453-4057qib7 3325 5 EV EV NNP cord-005453-4057qib7 3325 6 numbers number NNS cord-005453-4057qib7 3325 7 in in IN cord-005453-4057qib7 3325 8 individual individual JJ cord-005453-4057qib7 3325 9 patients patient NNS cord-005453-4057qib7 3325 10 compared compare VBN cord-005453-4057qib7 3325 11 to to IN cord-005453-4057qib7 3325 12 pretransplantation pretransplantation NN cord-005453-4057qib7 3325 13 values value NNS cord-005453-4057qib7 3325 14 ranged range VBD cord-005453-4057qib7 3325 15 from from IN cord-005453-4057qib7 3325 16 2-fold 2-fold CD cord-005453-4057qib7 3325 17 to to IN cord-005453-4057qib7 3325 18 7-fold 7-fold CD cord-005453-4057qib7 3325 19 . . . cord-005453-4057qib7 3326 1 Most Most JJS cord-005453-4057qib7 3326 2 patients patient NNS cord-005453-4057qib7 3326 3 showed show VBD cord-005453-4057qib7 3326 4 slight slight JJ cord-005453-4057qib7 3326 5 increases increase NNS cord-005453-4057qib7 3326 6 in in IN cord-005453-4057qib7 3326 7 EV ev NN cord-005453-4057qib7 3326 8 size size NN cord-005453-4057qib7 3326 9 after after IN cord-005453-4057qib7 3326 10 transplantation transplantation NN cord-005453-4057qib7 3326 11 . . . cord-005453-4057qib7 3327 1 Eight eight CD cord-005453-4057qib7 3327 2 of of IN cord-005453-4057qib7 3327 3 the the DT cord-005453-4057qib7 3327 4 patients patient NNS cord-005453-4057qib7 3327 5 showed show VBD cord-005453-4057qib7 3327 6 signs sign NNS cord-005453-4057qib7 3327 7 of of IN cord-005453-4057qib7 3327 8 infection infection NN cord-005453-4057qib7 3327 9 and and CC cord-005453-4057qib7 3327 10 received receive VBD cord-005453-4057qib7 3327 11 i.v i.v NNP cord-005453-4057qib7 3327 12 . . . cord-005453-4057qib7 3327 13 antibiotics antibiotic NNS cord-005453-4057qib7 3327 14 . . . cord-005453-4057qib7 3328 1 Increased increase VBN cord-005453-4057qib7 3328 2 levels level NNS cord-005453-4057qib7 3328 3 of of IN cord-005453-4057qib7 3328 4 EVs ev NNS cord-005453-4057qib7 3328 5 ( ( -LRB- cord-005453-4057qib7 3328 6 > > XX cord-005453-4057qib7 3328 7 2-fold 2-fold CD cord-005453-4057qib7 3328 8 ) ) -RRB- cord-005453-4057qib7 3328 9 were be VBD cord-005453-4057qib7 3328 10 recorded record VBN cord-005453-4057qib7 3328 11 in in IN cord-005453-4057qib7 3328 12 three three CD cord-005453-4057qib7 3328 13 patients patient NNS cord-005453-4057qib7 3328 14 during during IN cord-005453-4057qib7 3328 15 these these DT cord-005453-4057qib7 3328 16 episodes episode NNS cord-005453-4057qib7 3328 17 . . . cord-005453-4057qib7 3329 1 Furthermore furthermore RB cord-005453-4057qib7 3329 2 , , , cord-005453-4057qib7 3329 3 increased increase VBN cord-005453-4057qib7 3329 4 EV ev NN cord-005453-4057qib7 3329 5 numbers number NNS cord-005453-4057qib7 3329 6 were be VBD cord-005453-4057qib7 3329 7 observed observe VBN cord-005453-4057qib7 3329 8 in in IN cord-005453-4057qib7 3329 9 a a DT cord-005453-4057qib7 3329 10 patient patient NN cord-005453-4057qib7 3329 11 who who WP cord-005453-4057qib7 3329 12 required require VBD cord-005453-4057qib7 3329 13 i.v i.v NNP cord-005453-4057qib7 3329 14 . . . cord-005453-4057qib7 3329 15 antiviral antiviral JJ cord-005453-4057qib7 3329 16 therapy therapy NN cord-005453-4057qib7 3329 17 for for IN cord-005453-4057qib7 3329 18 CMV CMV NNP cord-005453-4057qib7 3329 19 reactivation reactivation NN cord-005453-4057qib7 3329 20 . . . cord-005453-4057qib7 3330 1 Acute acute JJ cord-005453-4057qib7 3330 2 grade grade NN cord-005453-4057qib7 3331 1 I -PRON- PRP cord-005453-4057qib7 3331 2 GvHD GvHD NNP cord-005453-4057qib7 3331 3 was be VBD cord-005453-4057qib7 3331 4 observed observe VBN cord-005453-4057qib7 3331 5 in in IN cord-005453-4057qib7 3331 6 five five CD cord-005453-4057qib7 3331 7 patients patient NNS cord-005453-4057qib7 3331 8 of of IN cord-005453-4057qib7 3331 9 which which WDT cord-005453-4057qib7 3331 10 two two CD cord-005453-4057qib7 3331 11 had have VBD cord-005453-4057qib7 3331 12 increased increase VBN cord-005453-4057qib7 3331 13 EV ev NN cord-005453-4057qib7 3331 14 numbers number NNS cord-005453-4057qib7 3331 15 ( ( -LRB- cord-005453-4057qib7 3331 16 > > XX cord-005453-4057qib7 3331 17 2-fold 2-fold CD cord-005453-4057qib7 3331 18 ) ) -RRB- cord-005453-4057qib7 3331 19 . . . cord-005453-4057qib7 3332 1 One one CD cord-005453-4057qib7 3332 2 patient patient NN cord-005453-4057qib7 3332 3 developed develop VBD cord-005453-4057qib7 3332 4 grade grade NN cord-005453-4057qib7 3332 5 IV IV NNP cord-005453-4057qib7 3332 6 GvHD GvHD NNP cord-005453-4057qib7 3332 7 which which WDT cord-005453-4057qib7 3332 8 was be VBD cord-005453-4057qib7 3332 9 accompanied accompany VBN cord-005453-4057qib7 3332 10 by by IN cord-005453-4057qib7 3332 11 a a DT cord-005453-4057qib7 3332 12 4-fold 4-fold CD cord-005453-4057qib7 3332 13 increase increase NN cord-005453-4057qib7 3332 14 in in IN cord-005453-4057qib7 3332 15 EV EV NNP cord-005453-4057qib7 3332 16 numbers number NNS cord-005453-4057qib7 3332 17 . . . cord-005453-4057qib7 3333 1 Interestingly interestingly RB cord-005453-4057qib7 3333 2 , , , cord-005453-4057qib7 3333 3 progressively progressively RB cord-005453-4057qib7 3333 4 increasing increase VBG cord-005453-4057qib7 3333 5 EV EV NNP cord-005453-4057qib7 3333 6 numbers number NNS cord-005453-4057qib7 3333 7 preceded precede VBD cord-005453-4057qib7 3333 8 the the DT cord-005453-4057qib7 3333 9 detection detection NN cord-005453-4057qib7 3333 10 of of IN cord-005453-4057qib7 3333 11 early early JJ cord-005453-4057qib7 3333 12 relapse relapse NN cord-005453-4057qib7 3333 13 in in IN cord-005453-4057qib7 3333 14 a a DT cord-005453-4057qib7 3333 15 pre pre NN cord-005453-4057qib7 3333 16 - - NN cord-005453-4057qib7 3333 17 B b NN cord-005453-4057qib7 3333 18 ALL all DT cord-005453-4057qib7 3333 19 patient patient NN cord-005453-4057qib7 3333 20 by by IN cord-005453-4057qib7 3333 21 three three CD cord-005453-4057qib7 3333 22 weeks week NNS cord-005453-4057qib7 3333 23 . . . cord-005453-4057qib7 3334 1 RNA rna NN cord-005453-4057qib7 3334 2 isolation isolation NN cord-005453-4057qib7 3334 3 from from IN cord-005453-4057qib7 3334 4 trapped trap VBN cord-005453-4057qib7 3334 5 EVs ev NNS cord-005453-4057qib7 3334 6 yielded yield VBD cord-005453-4057qib7 3334 7 sufficient sufficient JJ cord-005453-4057qib7 3334 8 material material NN cord-005453-4057qib7 3334 9 for for IN cord-005453-4057qib7 3334 10 miRNA miRNA NNP cord-005453-4057qib7 3334 11 profiling profiling NN cord-005453-4057qib7 3334 12 . . . cord-005453-4057qib7 3335 1 Here here RB cord-005453-4057qib7 3335 2 , , , cord-005453-4057qib7 3335 3 first first RB cord-005453-4057qib7 3335 4 miRNA miRNA NNP cord-005453-4057qib7 3335 5 profiling profiling NN cord-005453-4057qib7 3335 6 data datum NNS cord-005453-4057qib7 3335 7 demonstrated demonstrate VBD cord-005453-4057qib7 3335 8 that that IN cord-005453-4057qib7 3335 9 miRNAs miRNAs NNP cord-005453-4057qib7 3335 10 were be VBD cord-005453-4057qib7 3335 11 detected detect VBN cord-005453-4057qib7 3335 12 in in IN cord-005453-4057qib7 3335 13 EV EV NNP cord-005453-4057qib7 3335 14 samples sample NNS cord-005453-4057qib7 3335 15 ( ( -LRB- cord-005453-4057qib7 3335 16 miR-103a mir-103a CD cord-005453-4057qib7 3335 17 , , , cord-005453-4057qib7 3335 18 -23a -23a NNP cord-005453-4057qib7 3335 19 , , , cord-005453-4057qib7 3335 20 -30c -30c JJ cord-005453-4057qib7 3335 21 , , , cord-005453-4057qib7 3335 22 -142 -142 NNP cord-005453-4057qib7 3335 23 and and CC cord-005453-4057qib7 3335 24 -451a -451a NNP cord-005453-4057qib7 3335 25 ) ) -RRB- cord-005453-4057qib7 3335 26 , , , cord-005453-4057qib7 3335 27 and and CC cord-005453-4057qib7 3335 28 that that IN cord-005453-4057qib7 3335 29 acoustically acoustically RB cord-005453-4057qib7 3335 30 enriched enrich VBN cord-005453-4057qib7 3335 31 EVs ev NNS cord-005453-4057qib7 3335 32 were be VBD cord-005453-4057qib7 3335 33 not not RB cord-005453-4057qib7 3335 34 affected affect VBN cord-005453-4057qib7 3335 35 by by IN cord-005453-4057qib7 3335 36 hemolysis hemolysis NN cord-005453-4057qib7 3335 37 in in IN cord-005453-4057qib7 3335 38 contrast contrast NN cord-005453-4057qib7 3335 39 to to IN cord-005453-4057qib7 3335 40 the the DT cord-005453-4057qib7 3335 41 corresponding corresponding JJ cord-005453-4057qib7 3335 42 whole whole JJ cord-005453-4057qib7 3335 43 plasma plasma NN cord-005453-4057qib7 3335 44 samples sample NNS cord-005453-4057qib7 3335 45 ( ( -LRB- cord-005453-4057qib7 3335 46 dCq dcq NN cord-005453-4057qib7 3335 47 of of IN cord-005453-4057qib7 3335 48 miR-23a miR-23a NNP cord-005453-4057qib7 3335 49 and and CC cord-005453-4057qib7 3335 50 miR-451a mir-451a CD cord-005453-4057qib7 3335 51 ) ) -RRB- cord-005453-4057qib7 3335 52 . . . cord-005453-4057qib7 3336 1 Conclusions conclusion NNS cord-005453-4057qib7 3336 2 : : : cord-005453-4057qib7 3337 1 Acoustic acoustic JJ cord-005453-4057qib7 3337 2 trapping trapping NN cord-005453-4057qib7 3337 3 allows allow VBZ cord-005453-4057qib7 3337 4 for for IN cord-005453-4057qib7 3337 5 efficient efficient JJ cord-005453-4057qib7 3337 6 and and CC cord-005453-4057qib7 3337 7 rapid rapid JJ cord-005453-4057qib7 3337 8 enrichment enrichment NN cord-005453-4057qib7 3337 9 of of IN cord-005453-4057qib7 3337 10 EVs ev NNS cord-005453-4057qib7 3337 11 from from IN cord-005453-4057qib7 3337 12 small small JJ cord-005453-4057qib7 3337 13 volume volume NN cord-005453-4057qib7 3337 14 plasma plasma NN cord-005453-4057qib7 3337 15 samples sample NNS cord-005453-4057qib7 3337 16 . . . cord-005453-4057qib7 3338 1 Trapped trap VBN cord-005453-4057qib7 3338 2 EV ev NN cord-005453-4057qib7 3338 3 samples sample NNS cord-005453-4057qib7 3338 4 contain contain VBP cord-005453-4057qib7 3338 5 sufficient sufficient JJ cord-005453-4057qib7 3338 6 amounts amount NNS cord-005453-4057qib7 3338 7 of of IN cord-005453-4057qib7 3338 8 miRNA miRNA NNP cord-005453-4057qib7 3338 9 for for IN cord-005453-4057qib7 3338 10 downstream downstream JJ cord-005453-4057qib7 3338 11 analysis analysis NN cord-005453-4057qib7 3338 12 and and CC cord-005453-4057qib7 3338 13 are be VBP cord-005453-4057qib7 3338 14 thus thus RB cord-005453-4057qib7 3338 15 promising promising JJ cord-005453-4057qib7 3338 16 candidates candidate NNS cord-005453-4057qib7 3338 17 for for IN cord-005453-4057qib7 3338 18 biomarker biomarker NN cord-005453-4057qib7 3338 19 development development NN cord-005453-4057qib7 3338 20 in in IN cord-005453-4057qib7 3338 21 transplantation transplantation NN cord-005453-4057qib7 3338 22 . . . cord-005453-4057qib7 3339 1 Disclosure disclosure NN cord-005453-4057qib7 3339 2 : : : cord-005453-4057qib7 3339 3 Laurell Laurell NNP cord-005453-4057qib7 3339 4 and and CC cord-005453-4057qib7 3339 5 Scheding Scheding NNP cord-005453-4057qib7 3339 6 are be VBP cord-005453-4057qib7 3339 7 founders founder NNS cord-005453-4057qib7 3339 8 and and CC cord-005453-4057qib7 3339 9 board board NN cord-005453-4057qib7 3339 10 members member NNS cord-005453-4057qib7 3339 11 of of IN cord-005453-4057qib7 3339 12 Acousort Acousort NNP cord-005453-4057qib7 3339 13 AB AB NNP cord-005453-4057qib7 3339 14 , , , cord-005453-4057qib7 3339 15 a a DT cord-005453-4057qib7 3339 16 Lund Lund NNP cord-005453-4057qib7 3339 17 - - HYPH cord-005453-4057qib7 3339 18 based base VBN cord-005453-4057qib7 3339 19 biotech biotech JJ cord-005453-4057qib7 3339 20 SME SME NNP cord-005453-4057qib7 3339 21 that that WDT cord-005453-4057qib7 3339 22 develops develop VBZ cord-005453-4057qib7 3339 23 particle particle NN cord-005453-4057qib7 3339 24 and and CC cord-005453-4057qib7 3339 25 cell cell NN cord-005453-4057qib7 3339 26 sorting sorting NN cord-005453-4057qib7 3339 27 methods method NNS cord-005453-4057qib7 3339 28 based base VBN cord-005453-4057qib7 3339 29 on on IN cord-005453-4057qib7 3339 30 ultrasound ultrasound NN cord-005453-4057qib7 3339 31 . . . cord-005453-4057qib7 3340 1 The the DT cord-005453-4057qib7 3340 2 incidence incidence NN cord-005453-4057qib7 3340 3 , , , cord-005453-4057qib7 3340 4 risk risk NN cord-005453-4057qib7 3340 5 factors factor NNS cord-005453-4057qib7 3340 6 and and CC cord-005453-4057qib7 3340 7 outcomes outcome NNS cord-005453-4057qib7 3340 8 of of IN cord-005453-4057qib7 3340 9 primary primary JJ cord-005453-4057qib7 3340 10 poor poor JJ cord-005453-4057qib7 3340 11 graft graft NN cord-005453-4057qib7 3340 12 function function NN cord-005453-4057qib7 3340 13 after after IN cord-005453-4057qib7 3340 14 allogeneic allogeneic NN cord-005453-4057qib7 3340 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 3340 16 stem stem NN cord-005453-4057qib7 3340 17 cell cell NN cord-005453-4057qib7 3340 18 transplantation transplantation NN cord-005453-4057qib7 3340 19 Fei Fei NNP cord-005453-4057qib7 3340 20 Gao Gao NNP cord-005453-4057qib7 3340 21 1,2 1,2 CD cord-005453-4057qib7 3340 22 , , , cord-005453-4057qib7 3340 23 Jimin Jimin NNP cord-005453-4057qib7 3340 24 Shi Shi NNP cord-005453-4057qib7 3340 25 1,2 1,2 CD cord-005453-4057qib7 3340 26 , , , cord-005453-4057qib7 3340 27 Yi Yi NNP cord-005453-4057qib7 3340 28 Luo Luo NNP cord-005453-4057qib7 3340 29 1,2 1,2 CD cord-005453-4057qib7 3340 30 , , , cord-005453-4057qib7 3340 31 Yamin Yamin NNP cord-005453-4057qib7 3340 32 Tan Tan NNP cord-005453-4057qib7 3340 33 1,2 1,2 CD cord-005453-4057qib7 3340 34 , , , cord-005453-4057qib7 3340 35 Xiaoyu Xiaoyu NNP cord-005453-4057qib7 3340 36 Lai Lai NNP cord-005453-4057qib7 3340 37 1,2 1,2 CD cord-005453-4057qib7 3340 38 , , , cord-005453-4057qib7 3340 39 Jian Jian NNP cord-005453-4057qib7 3340 40 Yu Yu NNP cord-005453-4057qib7 3340 41 1,2 1,2 CD cord-005453-4057qib7 3340 42 , , , cord-005453-4057qib7 3340 43 He -PRON- PRP cord-005453-4057qib7 3340 44 Huang Huang NNP cord-005453-4057qib7 3340 45 1,2 1,2 CD cord-005453-4057qib7 3340 46 , , , cord-005453-4057qib7 3340 47 Yanmin Yanmin NNP cord-005453-4057qib7 3340 48 Zhao Zhao NNP cord-005453-4057qib7 3340 49 1 1 CD cord-005453-4057qib7 3340 50 , , , cord-005453-4057qib7 3340 51 2 2 CD cord-005453-4057qib7 3340 52 Background background NN cord-005453-4057qib7 3340 53 : : : cord-005453-4057qib7 3341 1 Allogeneic allogeneic IN cord-005453-4057qib7 3341 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 3341 3 stem stem NN cord-005453-4057qib7 3341 4 cell cell NN cord-005453-4057qib7 3341 5 transplantation transplantation NN cord-005453-4057qib7 3341 6 ( ( -LRB- cord-005453-4057qib7 3341 7 allo allo NN cord-005453-4057qib7 3341 8 - - HYPH cord-005453-4057qib7 3341 9 HSCT HSCT NNP cord-005453-4057qib7 3341 10 ) ) -RRB- cord-005453-4057qib7 3341 11 is be VBZ cord-005453-4057qib7 3341 12 a a DT cord-005453-4057qib7 3341 13 curative curative JJ cord-005453-4057qib7 3341 14 therapy therapy NN cord-005453-4057qib7 3341 15 for for IN cord-005453-4057qib7 3341 16 both both DT cord-005453-4057qib7 3341 17 hematologic hematologic JJ cord-005453-4057qib7 3341 18 malignancy malignancy NN cord-005453-4057qib7 3341 19 and and CC cord-005453-4057qib7 3341 20 many many JJ cord-005453-4057qib7 3341 21 other other JJ cord-005453-4057qib7 3341 22 blood blood NN cord-005453-4057qib7 3341 23 disease disease NN cord-005453-4057qib7 3341 24 . . . cord-005453-4057qib7 3342 1 While while IN cord-005453-4057qib7 3342 2 , , , cord-005453-4057qib7 3342 3 primary primary JJ cord-005453-4057qib7 3342 4 poor poor JJ cord-005453-4057qib7 3342 5 graft graft NN cord-005453-4057qib7 3342 6 function function NN cord-005453-4057qib7 3342 7 ( ( -LRB- cord-005453-4057qib7 3342 8 PGF PGF NNP cord-005453-4057qib7 3342 9 ) ) -RRB- cord-005453-4057qib7 3342 10 is be VBZ cord-005453-4057qib7 3342 11 still still RB cord-005453-4057qib7 3342 12 a a DT cord-005453-4057qib7 3342 13 severe severe JJ cord-005453-4057qib7 3342 14 complication complication NN cord-005453-4057qib7 3342 15 following follow VBG cord-005453-4057qib7 3342 16 HSCT HSCT NNP cord-005453-4057qib7 3342 17 which which WDT cord-005453-4057qib7 3342 18 lead lead VBP cord-005453-4057qib7 3342 19 to to IN cord-005453-4057qib7 3342 20 poor poor JJ cord-005453-4057qib7 3342 21 prognosis prognosis NN cord-005453-4057qib7 3342 22 . . . cord-005453-4057qib7 3343 1 Up up IN cord-005453-4057qib7 3343 2 to to IN cord-005453-4057qib7 3343 3 now now RB cord-005453-4057qib7 3343 4 , , , cord-005453-4057qib7 3343 5 the the DT cord-005453-4057qib7 3343 6 incidence incidence NN cord-005453-4057qib7 3343 7 and and CC cord-005453-4057qib7 3343 8 risk risk NN cord-005453-4057qib7 3343 9 factors factor NNS cord-005453-4057qib7 3343 10 of of IN cord-005453-4057qib7 3343 11 PGF PGF NNP cord-005453-4057qib7 3343 12 have have VBP cord-005453-4057qib7 3343 13 not not RB cord-005453-4057qib7 3343 14 been be VBN cord-005453-4057qib7 3343 15 totally totally RB cord-005453-4057qib7 3343 16 revealed reveal VBN cord-005453-4057qib7 3343 17 . . . cord-005453-4057qib7 3344 1 Methods method NNS cord-005453-4057qib7 3344 2 : : : cord-005453-4057qib7 3344 3 From from IN cord-005453-4057qib7 3344 4 January January NNP cord-005453-4057qib7 3344 5 2013 2013 CD cord-005453-4057qib7 3344 6 to to IN cord-005453-4057qib7 3344 7 December December NNP cord-005453-4057qib7 3344 8 2017 2017 CD cord-005453-4057qib7 3344 9 , , , cord-005453-4057qib7 3344 10 a a DT cord-005453-4057qib7 3344 11 total total NN cord-005453-4057qib7 3344 12 of of IN cord-005453-4057qib7 3344 13 647 647 CD cord-005453-4057qib7 3344 14 patients patient NNS cord-005453-4057qib7 3344 15 who who WP cord-005453-4057qib7 3344 16 received receive VBD cord-005453-4057qib7 3344 17 allo allo NN cord-005453-4057qib7 3344 18 - - HYPH cord-005453-4057qib7 3344 19 HSCT HSCT NNP cord-005453-4057qib7 3344 20 in in IN cord-005453-4057qib7 3344 21 our -PRON- PRP$ cord-005453-4057qib7 3344 22 center center NN cord-005453-4057qib7 3344 23 were be VBD cord-005453-4057qib7 3344 24 analyzed analyze VBN cord-005453-4057qib7 3344 25 retrospectively retrospectively RB cord-005453-4057qib7 3344 26 . . . cord-005453-4057qib7 3345 1 There there EX cord-005453-4057qib7 3345 2 were be VBD cord-005453-4057qib7 3345 3 9 9 CD cord-005453-4057qib7 3345 4 males male NNS cord-005453-4057qib7 3345 5 ( ( -LRB- cord-005453-4057qib7 3345 6 47.4 47.4 CD cord-005453-4057qib7 3345 7 % % NN cord-005453-4057qib7 3345 8 ) ) -RRB- cord-005453-4057qib7 3345 9 and and CC cord-005453-4057qib7 3345 10 10 10 CD cord-005453-4057qib7 3345 11 females female NNS cord-005453-4057qib7 3345 12 ( ( -LRB- cord-005453-4057qib7 3345 13 52.6 52.6 CD cord-005453-4057qib7 3345 14 % % NN cord-005453-4057qib7 3345 15 ) ) -RRB- cord-005453-4057qib7 3345 16 with with IN cord-005453-4057qib7 3345 17 a a DT cord-005453-4057qib7 3345 18 median median JJ cord-005453-4057qib7 3345 19 age age NN cord-005453-4057qib7 3345 20 of of IN cord-005453-4057qib7 3345 21 36.21 36.21 CD cord-005453-4057qib7 3345 22 years year NNS cord-005453-4057qib7 3345 23 ( ( -LRB- cord-005453-4057qib7 3345 24 21 21 CD cord-005453-4057qib7 3345 25 - - SYM cord-005453-4057qib7 3345 26 49 49 CD cord-005453-4057qib7 3345 27 years year NNS cord-005453-4057qib7 3345 28 ) ) -RRB- cord-005453-4057qib7 3345 29 . . . cord-005453-4057qib7 3346 1 PGF PGF NNP cord-005453-4057qib7 3346 2 was be VBD cord-005453-4057qib7 3346 3 defined define VBN cord-005453-4057qib7 3346 4 as as IN cord-005453-4057qib7 3346 5 persistent persistent JJ cord-005453-4057qib7 3346 6 neutropenia neutropenia NN cord-005453-4057qib7 3346 7 ( ( -LRB- cord-005453-4057qib7 3346 8 ≤0.5×10 ≤0.5×10 NNP cord-005453-4057qib7 3346 9 9 9 CD cord-005453-4057qib7 3346 10 /L /L . cord-005453-4057qib7 3346 11 ) ) -RRB- cord-005453-4057qib7 3346 12 , , , cord-005453-4057qib7 3346 13 thrombocytopenia thrombocytopenia NNP cord-005453-4057qib7 3346 14 ( ( -LRB- cord-005453-4057qib7 3346 15 platelets≤20×10 platelets≤20×10 NN cord-005453-4057qib7 3346 16 9 9 CD cord-005453-4057qib7 3346 17 /L /L . cord-005453-4057qib7 3346 18 ) ) -RRB- cord-005453-4057qib7 3346 19 , , , cord-005453-4057qib7 3346 20 and/ and/ CD cord-005453-4057qib7 3346 21 or or CC cord-005453-4057qib7 3346 22 hemoglobin≤70 hemoglobin≤70 NNP cord-005453-4057qib7 3346 23 g g NNP cord-005453-4057qib7 3346 24 / / SYM cord-005453-4057qib7 3346 25 L l NN cord-005453-4057qib7 3346 26 after after IN cord-005453-4057qib7 3346 27 engraftment engraftment NN cord-005453-4057qib7 3346 28 with with IN cord-005453-4057qib7 3346 29 hypocellular hypocellular NNP cord-005453-4057qib7 3346 30 bone bone NN cord-005453-4057qib7 3346 31 marrow marrow NN cord-005453-4057qib7 3346 32 and and CC cord-005453-4057qib7 3346 33 full full JJ cord-005453-4057qib7 3346 34 donor donor NN cord-005453-4057qib7 3346 35 chimerism chimerism NN cord-005453-4057qib7 3346 36 , , , cord-005453-4057qib7 3346 37 without without IN cord-005453-4057qib7 3346 38 concurrent concurrent JJ cord-005453-4057qib7 3346 39 graft graft NN cord-005453-4057qib7 3346 40 - - HYPH cord-005453-4057qib7 3346 41 versus versus IN cord-005453-4057qib7 3346 42 - - HYPH cord-005453-4057qib7 3346 43 host host NN cord-005453-4057qib7 3346 44 disease disease NN cord-005453-4057qib7 3346 45 or or CC cord-005453-4057qib7 3346 46 disease disease NN cord-005453-4057qib7 3346 47 relapse relapse NN cord-005453-4057qib7 3346 48 . . . cord-005453-4057qib7 3347 1 Incidence incidence NN cord-005453-4057qib7 3347 2 was be VBD cord-005453-4057qib7 3347 3 calculated calculate VBN cord-005453-4057qib7 3347 4 from from IN cord-005453-4057qib7 3347 5 all all DT cord-005453-4057qib7 3347 6 patients patient NNS cord-005453-4057qib7 3347 7 . . . cord-005453-4057qib7 3348 1 Of of IN cord-005453-4057qib7 3348 2 the the DT cord-005453-4057qib7 3348 3 647 647 CD cord-005453-4057qib7 3348 4 total total JJ cord-005453-4057qib7 3348 5 patients patient NNS cord-005453-4057qib7 3348 6 , , , cord-005453-4057qib7 3348 7 nineteen nineteen CD cord-005453-4057qib7 3348 8 ( ( -LRB- cord-005453-4057qib7 3348 9 2.94 2.94 CD cord-005453-4057qib7 3348 10 % % NN cord-005453-4057qib7 3348 11 ) ) -RRB- cord-005453-4057qib7 3348 12 developed develop VBN cord-005453-4057qib7 3348 13 primary primary NN cord-005453-4057qib7 3348 14 PGF PGF NNP cord-005453-4057qib7 3348 15 . . . cord-005453-4057qib7 3349 1 A a DT cord-005453-4057qib7 3349 2 1:4 1:4 CD cord-005453-4057qib7 3349 3 ratio ratio NN cord-005453-4057qib7 3349 4 of of IN cord-005453-4057qib7 3349 5 nested nested JJ cord-005453-4057qib7 3349 6 case case NN cord-005453-4057qib7 3349 7 control control NN cord-005453-4057qib7 3349 8 study study NN cord-005453-4057qib7 3349 9 using use VBG cord-005453-4057qib7 3349 10 the the DT cord-005453-4057qib7 3349 11 good good JJ cord-005453-4057qib7 3349 12 graft graft NN cord-005453-4057qib7 3349 13 function function NN cord-005453-4057qib7 3349 14 ( ( -LRB- cord-005453-4057qib7 3349 15 GGF GGF NNP cord-005453-4057qib7 3349 16 ) ) -RRB- cord-005453-4057qib7 3349 17 subjects subject NNS cord-005453-4057qib7 3349 18 transplanted transplant VBN cord-005453-4057qib7 3349 19 in in IN cord-005453-4057qib7 3349 20 the the DT cord-005453-4057qib7 3349 21 same same JJ cord-005453-4057qib7 3349 22 year year NN cord-005453-4057qib7 3349 23 with with IN cord-005453-4057qib7 3349 24 the the DT cord-005453-4057qib7 3349 25 same same JJ cord-005453-4057qib7 3349 26 sex sex NN cord-005453-4057qib7 3349 27 and and CC cord-005453-4057qib7 3349 28 age age NN cord-005453-4057qib7 3349 29 of of IN cord-005453-4057qib7 3349 30 ±5 ±5 NNS cord-005453-4057qib7 3349 31 years year NNS cord-005453-4057qib7 3349 32 was be VBD cord-005453-4057qib7 3349 33 carried carry VBN cord-005453-4057qib7 3349 34 out out RP cord-005453-4057qib7 3349 35 . . . cord-005453-4057qib7 3350 1 Results result NNS cord-005453-4057qib7 3350 2 : : : cord-005453-4057qib7 3351 1 Data datum NNS cord-005453-4057qib7 3351 2 was be VBD cord-005453-4057qib7 3351 3 analyzed analyze VBN cord-005453-4057qib7 3351 4 by by IN cord-005453-4057qib7 3351 5 univariate univariate JJ cord-005453-4057qib7 3351 6 and and CC cord-005453-4057qib7 3351 7 multivariate multivariate JJ cord-005453-4057qib7 3351 8 logistic logistic JJ cord-005453-4057qib7 3351 9 regression regression NN cord-005453-4057qib7 3351 10 , , , cord-005453-4057qib7 3351 11 and and CC cord-005453-4057qib7 3351 12 univariate univariate JJ cord-005453-4057qib7 3351 13 analysis analysis NN cord-005453-4057qib7 3351 14 identified identify VBD cord-005453-4057qib7 3351 15 disease disease NN cord-005453-4057qib7 3351 16 species specie NNS cord-005453-4057qib7 3351 17 , , , cord-005453-4057qib7 3351 18 the the DT cord-005453-4057qib7 3351 19 time time NN cord-005453-4057qib7 3351 20 from from IN cord-005453-4057qib7 3351 21 diagnosis diagnosis NN cord-005453-4057qib7 3351 22 to to IN cord-005453-4057qib7 3351 23 transplantation transplantation NN cord-005453-4057qib7 3351 24 , , , cord-005453-4057qib7 3351 25 disease disease NN cord-005453-4057qib7 3351 26 states state NNS cord-005453-4057qib7 3351 27 , , , cord-005453-4057qib7 3351 28 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 3351 29 , , , cord-005453-4057qib7 3351 30 splenomegaly splenomegaly NN cord-005453-4057qib7 3351 31 , , , cord-005453-4057qib7 3351 32 serum serum NN cord-005453-4057qib7 3351 33 ferritin ferritin NN cord-005453-4057qib7 3351 34 ( ( -LRB- cord-005453-4057qib7 3351 35 SF SF NNP cord-005453-4057qib7 3351 36 ) ) -RRB- cord-005453-4057qib7 3351 37 level level NN cord-005453-4057qib7 3351 38 , , , cord-005453-4057qib7 3351 39 CMV CMV NNP cord-005453-4057qib7 3351 40 infection infection NN cord-005453-4057qib7 3351 41 , , , cord-005453-4057qib7 3351 42 mononuclear mononuclear NN cord-005453-4057qib7 3351 43 and and CC cord-005453-4057qib7 3351 44 CD34 CD34 NNP cord-005453-4057qib7 3351 45 + + CC cord-005453-4057qib7 3351 46 cells cell NNS cord-005453-4057qib7 3351 47 in in IN cord-005453-4057qib7 3351 48 graft graft NN cord-005453-4057qib7 3351 49 as as IN cord-005453-4057qib7 3351 50 potential potential JJ cord-005453-4057qib7 3351 51 risk risk NN cord-005453-4057qib7 3351 52 factors factor NNS cord-005453-4057qib7 3351 53 ( ( -LRB- cord-005453-4057qib7 3351 54 P p NN cord-005453-4057qib7 3351 55 < < XX cord-005453-4057qib7 3351 56 0.1 0.1 CD cord-005453-4057qib7 3351 57 ) ) -RRB- cord-005453-4057qib7 3351 58 for for IN cord-005453-4057qib7 3351 59 PGF PGF NNP cord-005453-4057qib7 3351 60 . . . cord-005453-4057qib7 3352 1 multivariate multivariate JJ cord-005453-4057qib7 3352 2 analysis analysis NN cord-005453-4057qib7 3352 3 identified identify VBD cord-005453-4057qib7 3352 4 3 3 CD cord-005453-4057qib7 3352 5 elements element NNS cord-005453-4057qib7 3352 6 as as IN cord-005453-4057qib7 3352 7 the the DT cord-005453-4057qib7 3352 8 independent independent JJ cord-005453-4057qib7 3352 9 risk risk NN cord-005453-4057qib7 3352 10 factors factor NNS cord-005453-4057qib7 3352 11 ( ( -LRB- cord-005453-4057qib7 3352 12 P p NN cord-005453-4057qib7 3352 13 < < XX cord-005453-4057qib7 3352 14 0.05 0.05 CD cord-005453-4057qib7 3352 15 ) ) -RRB- cord-005453-4057qib7 3352 16 , , , cord-005453-4057qib7 3352 17 including include VBG cord-005453-4057qib7 3352 18 CD34 CD34 NNP cord-005453-4057qib7 3352 19 + + CC cord-005453-4057qib7 3352 20 cells cell NNS cord-005453-4057qib7 3352 21 < < XX cord-005453-4057qib7 3352 22 5×10 5×10 CD cord-005453-4057qib7 3352 23 5 5 CD cord-005453-4057qib7 3353 1 / / NFP cord-005453-4057qib7 3353 2 Background background NN cord-005453-4057qib7 3353 3 : : : cord-005453-4057qib7 3354 1 Transplant transplant NN cord-005453-4057qib7 3354 2 survivors survivor NNS cord-005453-4057qib7 3354 3 affected affect VBN cord-005453-4057qib7 3354 4 by by IN cord-005453-4057qib7 3354 5 cGVHD cGVHD NNP cord-005453-4057qib7 3354 6 usually usually RB cord-005453-4057qib7 3354 7 take take VB cord-005453-4057qib7 3354 8 one one CD cord-005453-4057qib7 3354 9 or or CC cord-005453-4057qib7 3354 10 more more JJR cord-005453-4057qib7 3354 11 immunosuppressants immunosuppressant NNS cord-005453-4057qib7 3354 12 , , , cord-005453-4057qib7 3354 13 as as RB cord-005453-4057qib7 3354 14 well well RB cord-005453-4057qib7 3354 15 as as IN cord-005453-4057qib7 3354 16 prophylactic prophylactic JJ cord-005453-4057qib7 3354 17 antimicrobials antimicrobial NNS cord-005453-4057qib7 3354 18 ; ; : cord-005453-4057qib7 3354 19 use use NN cord-005453-4057qib7 3354 20 of of IN cord-005453-4057qib7 3354 21 multiple multiple JJ cord-005453-4057qib7 3354 22 medication medication NN cord-005453-4057qib7 3354 23 classes class NNS cord-005453-4057qib7 3354 24 concurrently concurrently RB cord-005453-4057qib7 3354 25 poses pose VBZ cord-005453-4057qib7 3354 26 a a DT cord-005453-4057qib7 3354 27 risk risk NN cord-005453-4057qib7 3354 28 for for IN cord-005453-4057qib7 3354 29 drug drug NN cord-005453-4057qib7 3354 30 - - HYPH cord-005453-4057qib7 3354 31 drug drug NN cord-005453-4057qib7 3354 32 interactions interaction NNS cord-005453-4057qib7 3354 33 or or CC cord-005453-4057qib7 3354 34 amplified amplify VBN cord-005453-4057qib7 3354 35 side side NN cord-005453-4057qib7 3354 36 - - HYPH cord-005453-4057qib7 3354 37 effects effect NNS cord-005453-4057qib7 3354 38 . . . cord-005453-4057qib7 3355 1 The the DT cord-005453-4057qib7 3355 2 use use NN cord-005453-4057qib7 3355 3 of of IN cord-005453-4057qib7 3355 4 medications medication NNS cord-005453-4057qib7 3355 5 other other JJ cord-005453-4057qib7 3355 6 than than IN cord-005453-4057qib7 3355 7 cGVHD cgvhd JJ cord-005453-4057qib7 3355 8 - - HYPH cord-005453-4057qib7 3355 9 direct direct JJ cord-005453-4057qib7 3355 10 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 3355 11 therapies therapy NNS cord-005453-4057qib7 3355 12 has have VBZ cord-005453-4057qib7 3355 13 not not RB cord-005453-4057qib7 3355 14 been be VBN cord-005453-4057qib7 3355 15 well well RB cord-005453-4057qib7 3355 16 - - HYPH cord-005453-4057qib7 3355 17 characterized characterize VBN cord-005453-4057qib7 3355 18 . . . cord-005453-4057qib7 3356 1 This this DT cord-005453-4057qib7 3356 2 study study NN cord-005453-4057qib7 3356 3 aims aim VBZ cord-005453-4057qib7 3356 4 to to TO cord-005453-4057qib7 3356 5 evaluate evaluate VB cord-005453-4057qib7 3356 6 patterns pattern NNS cord-005453-4057qib7 3356 7 of of IN cord-005453-4057qib7 3356 8 opioid opioid JJ cord-005453-4057qib7 3356 9 analgesic analgesic JJ cord-005453-4057qib7 3356 10 use use NN cord-005453-4057qib7 3356 11 in in IN cord-005453-4057qib7 3356 12 a a DT cord-005453-4057qib7 3356 13 cohort cohort NN cord-005453-4057qib7 3356 14 of of IN cord-005453-4057qib7 3356 15 patients patient NNS cord-005453-4057qib7 3356 16 severely severely RB cord-005453-4057qib7 3356 17 affected affect VBN cord-005453-4057qib7 3356 18 by by IN cord-005453-4057qib7 3356 19 cGVHD cGVHD NNP cord-005453-4057qib7 3356 20 . . . cord-005453-4057qib7 3357 1 Methods method NNS cord-005453-4057qib7 3357 2 : : : cord-005453-4057qib7 3357 3 Patients patient NNS cord-005453-4057qib7 3357 4 ( ( -LRB- cord-005453-4057qib7 3357 5 n=335 n=335 NNP cord-005453-4057qib7 3357 6 ) ) -RRB- cord-005453-4057qib7 3357 7 with with IN cord-005453-4057qib7 3357 8 cGVHD cGVHD NNP cord-005453-4057qib7 3357 9 were be VBD cord-005453-4057qib7 3357 10 consecutively consecutively RB cord-005453-4057qib7 3357 11 enrolled enrol VBN cord-005453-4057qib7 3357 12 in in IN cord-005453-4057qib7 3357 13 a a DT cord-005453-4057qib7 3357 14 cross cross JJ cord-005453-4057qib7 3357 15 - - JJ cord-005453-4057qib7 3357 16 sectional sectional JJ cord-005453-4057qib7 3357 17 natural natural JJ cord-005453-4057qib7 3357 18 history history NN cord-005453-4057qib7 3357 19 study study NN cord-005453-4057qib7 3357 20 ( ( -LRB- cord-005453-4057qib7 3357 21 NCT00092235 NCT00092235 NNP cord-005453-4057qib7 3357 22 ) ) -RRB- cord-005453-4057qib7 3357 23 from from IN cord-005453-4057qib7 3357 24 10/2004 10/2004 CD cord-005453-4057qib7 3357 25 - - HYPH cord-005453-4057qib7 3357 26 12/2016 12/2016 CD cord-005453-4057qib7 3357 27 at at IN cord-005453-4057qib7 3357 28 the the DT cord-005453-4057qib7 3357 29 NIH NIH NNP cord-005453-4057qib7 3357 30 . . . cord-005453-4057qib7 3358 1 Participants participant NNS cord-005453-4057qib7 3358 2 underwent undergo VBD cord-005453-4057qib7 3358 3 a a DT cord-005453-4057qib7 3358 4 comprehensive comprehensive JJ cord-005453-4057qib7 3358 5 evaluation evaluation NN cord-005453-4057qib7 3358 6 including include VBG cord-005453-4057qib7 3358 7 a a DT cord-005453-4057qib7 3358 8 detailed detailed JJ cord-005453-4057qib7 3358 9 history history NN cord-005453-4057qib7 3358 10 and and CC cord-005453-4057qib7 3358 11 physical physical JJ cord-005453-4057qib7 3358 12 examination examination NN cord-005453-4057qib7 3358 13 ( ( -LRB- cord-005453-4057qib7 3358 14 including include VBG cord-005453-4057qib7 3358 15 current current JJ cord-005453-4057qib7 3358 16 medications medication NNS cord-005453-4057qib7 3358 17 ) ) -RRB- cord-005453-4057qib7 3358 18 , , , cord-005453-4057qib7 3358 19 multidisciplinary multidisciplinary JJ cord-005453-4057qib7 3358 20 evaluations evaluation NNS cord-005453-4057qib7 3358 21 , , , cord-005453-4057qib7 3358 22 and and CC cord-005453-4057qib7 3358 23 laboratory laboratory NN cord-005453-4057qib7 3358 24 and and CC cord-005453-4057qib7 3358 25 diagnostic diagnostic JJ cord-005453-4057qib7 3358 26 testing testing NN cord-005453-4057qib7 3358 27 . . . cord-005453-4057qib7 3359 1 For for IN cord-005453-4057qib7 3359 2 this this DT cord-005453-4057qib7 3359 3 analysis analysis NN cord-005453-4057qib7 3359 4 , , , cord-005453-4057qib7 3359 5 respondents respondent NNS cord-005453-4057qib7 3359 6 were be VBD cord-005453-4057qib7 3359 7 classified classify VBN cord-005453-4057qib7 3359 8 as as IN cord-005453-4057qib7 3359 9 receiving receive VBG cord-005453-4057qib7 3359 10 or or CC cord-005453-4057qib7 3359 11 not not RB cord-005453-4057qib7 3359 12 receiving receive VBG cord-005453-4057qib7 3359 13 an an DT cord-005453-4057qib7 3359 14 opioid opioid JJ cord-005453-4057qib7 3359 15 analgesic analgesic NN cord-005453-4057qib7 3359 16 . . . cord-005453-4057qib7 3360 1 Following follow VBG cord-005453-4057qib7 3360 2 the the DT cord-005453-4057qib7 3360 3 initial initial JJ cord-005453-4057qib7 3360 4 screening screening NN cord-005453-4057qib7 3360 5 by by IN cord-005453-4057qib7 3360 6 univariate univariate JJ cord-005453-4057qib7 3360 7 methods method NNS cord-005453-4057qib7 3360 8 ( ( -LRB- cord-005453-4057qib7 3360 9 n=335 n=335 NNP cord-005453-4057qib7 3360 10 ) ) -RRB- cord-005453-4057qib7 3360 11 , , , cord-005453-4057qib7 3360 12 multivariable multivariable JJ cord-005453-4057qib7 3360 13 logistic logistic JJ cord-005453-4057qib7 3360 14 regression regression NN cord-005453-4057qib7 3360 15 analysis analysis NN cord-005453-4057qib7 3360 16 ( ( -LRB- cord-005453-4057qib7 3360 17 MLR MLR NNP cord-005453-4057qib7 3360 18 ) ) -RRB- cord-005453-4057qib7 3360 19 was be VBD cord-005453-4057qib7 3360 20 used use VBN cord-005453-4057qib7 3360 21 to to TO cord-005453-4057qib7 3360 22 identify identify VB cord-005453-4057qib7 3360 23 a a DT cord-005453-4057qib7 3360 24 set set NN cord-005453-4057qib7 3360 25 of of IN cord-005453-4057qib7 3360 26 factors factor NNS cord-005453-4057qib7 3360 27 which which WDT cord-005453-4057qib7 3360 28 could could MD cord-005453-4057qib7 3360 29 jointly jointly RB cord-005453-4057qib7 3360 30 impact impact VB cord-005453-4057qib7 3360 31 opioid opioid NN cord-005453-4057qib7 3360 32 use use NN cord-005453-4057qib7 3360 33 . . . cord-005453-4057qib7 3361 1 For for IN cord-005453-4057qib7 3361 2 MLR MLR NNP cord-005453-4057qib7 3361 3 data datum NNS cord-005453-4057qib7 3361 4 were be VBD cord-005453-4057qib7 3361 5 divided divide VBN cord-005453-4057qib7 3361 6 into into IN cord-005453-4057qib7 3361 7 a a DT cord-005453-4057qib7 3361 8 training training NN cord-005453-4057qib7 3361 9 ( ( -LRB- cord-005453-4057qib7 3361 10 n=167 n=167 CD cord-005453-4057qib7 3361 11 patients patient NNS cord-005453-4057qib7 3361 12 ) ) -RRB- cord-005453-4057qib7 3361 13 and and CC cord-005453-4057qib7 3361 14 a a DT cord-005453-4057qib7 3361 15 validation validation NN cord-005453-4057qib7 3361 16 set set NN cord-005453-4057qib7 3361 17 ( ( -LRB- cord-005453-4057qib7 3361 18 n=168 n=168 NNP cord-005453-4057qib7 3361 19 ) ) -RRB- cord-005453-4057qib7 3361 20 . . . cord-005453-4057qib7 3362 1 Results result NNS cord-005453-4057qib7 3362 2 : : : cord-005453-4057qib7 3363 1 Study study NN cord-005453-4057qib7 3363 2 participants´median participants´median JJ cord-005453-4057qib7 3363 3 age age NN cord-005453-4057qib7 3363 4 was be VBD cord-005453-4057qib7 3363 5 48.5 48.5 CD cord-005453-4057qib7 3363 6 years year NNS cord-005453-4057qib7 3363 7 ( ( -LRB- cord-005453-4057qib7 3363 8 19 19 CD cord-005453-4057qib7 3363 9 - - SYM cord-005453-4057qib7 3363 10 75 75 CD cord-005453-4057qib7 3363 11 ) ) -RRB- cord-005453-4057qib7 3363 12 , , , cord-005453-4057qib7 3363 13 44 44 CD cord-005453-4057qib7 3363 14 % % NN cord-005453-4057qib7 3363 15 were be VBD cord-005453-4057qib7 3363 16 female female JJ cord-005453-4057qib7 3363 17 , , , cord-005453-4057qib7 3363 18 74 74 CD cord-005453-4057qib7 3363 19 % % NN cord-005453-4057qib7 3363 20 had have VBD cord-005453-4057qib7 3363 21 severe severe JJ cord-005453-4057qib7 3363 22 cGVHD cgvhd NN cord-005453-4057qib7 3363 23 per per IN cord-005453-4057qib7 3363 24 NIH NIH NNP cord-005453-4057qib7 3363 25 scoring scoring NN cord-005453-4057qib7 3363 26 criteria criterion NNS cord-005453-4057qib7 3363 27 , , , cord-005453-4057qib7 3363 28 and and CC cord-005453-4057qib7 3363 29 77 77 CD cord-005453-4057qib7 3363 30 % % NN cord-005453-4057qib7 3363 31 were be VBD cord-005453-4057qib7 3363 32 currently currently RB cord-005453-4057qib7 3363 33 receiving receive VBG cord-005453-4057qib7 3363 34 high high JJ cord-005453-4057qib7 3363 35 or or CC cord-005453-4057qib7 3363 36 moderate moderate JJ cord-005453-4057qib7 3363 37 levels level NNS cord-005453-4057qib7 3363 38 of of IN cord-005453-4057qib7 3363 39 systemic systemic JJ cord-005453-4057qib7 3363 40 immunosuppression immunosuppression NN cord-005453-4057qib7 3363 41 . . . cord-005453-4057qib7 3364 1 Approximately approximately RB cord-005453-4057qib7 3364 2 one one CD cord-005453-4057qib7 3364 3 third third JJ cord-005453-4057qib7 3364 4 ( ( -LRB- cord-005453-4057qib7 3364 5 33 33 CD cord-005453-4057qib7 3364 6 % % NN cord-005453-4057qib7 3364 7 ) ) -RRB- cord-005453-4057qib7 3364 8 were be VBD cord-005453-4057qib7 3364 9 taking take VBG cord-005453-4057qib7 3364 10 opioid opioid JJ cord-005453-4057qib7 3364 11 analgesics analgesic NNS cord-005453-4057qib7 3364 12 ( ( -LRB- cord-005453-4057qib7 3364 13 OA OA NNP cord-005453-4057qib7 3364 14 ) ) -RRB- cord-005453-4057qib7 3364 15 . . . cord-005453-4057qib7 3365 1 Based base VBN cord-005453-4057qib7 3365 2 on on IN cord-005453-4057qib7 3365 3 the the DT cord-005453-4057qib7 3365 4 univariate univariate JJ cord-005453-4057qib7 3365 5 screening screening NN cord-005453-4057qib7 3365 6 results result NNS cord-005453-4057qib7 3365 7 ( ( -LRB- cord-005453-4057qib7 3365 8 p p NN cord-005453-4057qib7 3365 9 < < XX cord-005453-4057qib7 3365 10 = = SYM cord-005453-4057qib7 3365 11 0.05 0.05 CD cord-005453-4057qib7 3365 12 ) ) -RRB- cord-005453-4057qib7 3365 13 , , , cord-005453-4057qib7 3365 14 a a DT cord-005453-4057qib7 3365 15 set set NN cord-005453-4057qib7 3365 16 of of IN cord-005453-4057qib7 3365 17 24 24 CD cord-005453-4057qib7 3365 18 parameters parameter NNS cord-005453-4057qib7 3365 19 was be VBD cord-005453-4057qib7 3365 20 evaluated evaluate VBN cord-005453-4057qib7 3365 21 by by IN cord-005453-4057qib7 3365 22 univariate univariate JJ cord-005453-4057qib7 3365 23 logistic logistic JJ cord-005453-4057qib7 3365 24 regression regression NN cord-005453-4057qib7 3365 25 in in IN cord-005453-4057qib7 3365 26 the the DT cord-005453-4057qib7 3365 27 167-patient 167-patient CD cord-005453-4057qib7 3365 28 training training NN cord-005453-4057qib7 3365 29 set set NN cord-005453-4057qib7 3365 30 , , , cord-005453-4057qib7 3365 31 and and CC cord-005453-4057qib7 3365 32 the the DT cord-005453-4057qib7 3365 33 following follow VBG cord-005453-4057qib7 3365 34 parameters parameter NNS cord-005453-4057qib7 3365 35 retained retain VBD cord-005453-4057qib7 3365 36 their -PRON- PRP$ cord-005453-4057qib7 3365 37 significance significance NN cord-005453-4057qib7 3365 38 and and CC cord-005453-4057qib7 3365 39 were be VBD cord-005453-4057qib7 3365 40 included include VBN cord-005453-4057qib7 3365 41 in in IN cord-005453-4057qib7 3365 42 the the DT cord-005453-4057qib7 3365 43 MLR MLR NNP cord-005453-4057qib7 3365 44 model model NN cord-005453-4057qib7 3365 45 : : : cord-005453-4057qib7 3365 46 NIH NIH NNP cord-005453-4057qib7 3365 47 average average JJ cord-005453-4057qib7 3365 48 score score NN cord-005453-4057qib7 3365 49 per per IN cord-005453-4057qib7 3365 50 organ organ NN cord-005453-4057qib7 3365 51 , , , cord-005453-4057qib7 3365 52 total total JJ cord-005453-4057qib7 3365 53 LSS LSS NNP cord-005453-4057qib7 3365 54 , , , cord-005453-4057qib7 3365 55 patient patient JJ cord-005453-4057qib7 3365 56 impression impression NN cord-005453-4057qib7 3365 57 of of IN cord-005453-4057qib7 3365 58 severity severity NN cord-005453-4057qib7 3365 59 , , , cord-005453-4057qib7 3365 60 NIH NIH NNP cord-005453-4057qib7 3365 61 cGVHD cgvhd NN cord-005453-4057qib7 3365 62 severity severity NN cord-005453-4057qib7 3365 63 , , , cord-005453-4057qib7 3365 64 presence presence NN cord-005453-4057qib7 3365 65 of of IN cord-005453-4057qib7 3365 66 skin skin NN cord-005453-4057qib7 3365 67 erythema erythema NN cord-005453-4057qib7 3365 68 , , , cord-005453-4057qib7 3365 69 Karnofsky Karnofsky NNP cord-005453-4057qib7 3365 70 performance performance NN cord-005453-4057qib7 3365 71 score score NN cord-005453-4057qib7 3365 72 ( ( -LRB- cord-005453-4057qib7 3365 73 KPS KPS NNP cord-005453-4057qib7 3365 74 , , , cord-005453-4057qib7 3365 75 ) ) -RRB- cord-005453-4057qib7 3366 1 clinician clinician NN cord-005453-4057qib7 3366 2 's 's POS cord-005453-4057qib7 3366 3 therapeutic therapeutic JJ cord-005453-4057qib7 3366 4 intent intent NN cord-005453-4057qib7 3366 5 , , , cord-005453-4057qib7 3366 6 NIH NIH NNP cord-005453-4057qib7 3366 7 joint joint JJ cord-005453-4057qib7 3366 8 score score NN cord-005453-4057qib7 3366 9 , , , cord-005453-4057qib7 3366 10 and and CC cord-005453-4057qib7 3366 11 with with IN cord-005453-4057qib7 3366 12 the the DT cord-005453-4057qib7 3366 13 presence presence NN cord-005453-4057qib7 3366 14 of of IN cord-005453-4057qib7 3366 15 several several JJ cord-005453-4057qib7 3366 16 cGVHD cgvhd NN cord-005453-4057qib7 3366 17 symptoms symptom NNS cord-005453-4057qib7 3366 18 including include VBG cord-005453-4057qib7 3366 19 rashes rash NNS cord-005453-4057qib7 3366 20 , , , cord-005453-4057qib7 3366 21 mouth mouth NN cord-005453-4057qib7 3366 22 sores sore NNS cord-005453-4057qib7 3366 23 , , , cord-005453-4057qib7 3366 24 avoidance avoidance NN cord-005453-4057qib7 3366 25 of of IN cord-005453-4057qib7 3366 26 food food NN cord-005453-4057qib7 3366 27 , , , cord-005453-4057qib7 3366 28 vomiting vomiting NN cord-005453-4057qib7 3366 29 , , , cord-005453-4057qib7 3366 30 weight weight NN cord-005453-4057qib7 3366 31 loss loss NN cord-005453-4057qib7 3366 32 , , , cord-005453-4057qib7 3366 33 joint joint NN cord-005453-4057qib7 3366 34 and and CC cord-005453-4057qib7 3366 35 muscle muscle NN cord-005453-4057qib7 3366 36 aches ache NNS cord-005453-4057qib7 3366 37 , , , cord-005453-4057qib7 3366 38 joint joint JJ cord-005453-4057qib7 3366 39 limitation limitation NN cord-005453-4057qib7 3366 40 , , , cord-005453-4057qib7 3366 41 energy energy NN cord-005453-4057qib7 3366 42 loss loss NN cord-005453-4057qib7 3366 43 , , , cord-005453-4057qib7 3366 44 need need VBP cord-005453-4057qib7 3366 45 for for IN cord-005453-4057qib7 3366 46 naps nap NNS cord-005453-4057qib7 3366 47 , , , cord-005453-4057qib7 3366 48 fevers fever NNS cord-005453-4057qib7 3366 49 , , , cord-005453-4057qib7 3366 50 anxiety anxiety NN cord-005453-4057qib7 3366 51 . . . cord-005453-4057qib7 3367 1 Multivariable multivariable JJ cord-005453-4057qib7 3367 2 logistic logistic JJ cord-005453-4057qib7 3367 3 regression regression NN cord-005453-4057qib7 3367 4 identified identify VBD cord-005453-4057qib7 3367 5 KPS KPS NNP cord-005453-4057qib7 3367 6 < < XX cord-005453-4057qib7 3367 7 77 77 CD cord-005453-4057qib7 3367 8 % % NN cord-005453-4057qib7 3367 9 as as IN cord-005453-4057qib7 3367 10 predictive predictive NN cord-005453-4057qib7 3367 11 of of IN cord-005453-4057qib7 3367 12 OA OA NNP cord-005453-4057qib7 3367 13 use use NN cord-005453-4057qib7 3367 14 , , , cord-005453-4057qib7 3367 15 OR or CC cord-005453-4057qib7 3367 16 0.92 0.92 CD cord-005453-4057qib7 3367 17 , , , cord-005453-4057qib7 3367 18 95 95 CD cord-005453-4057qib7 3367 19 % % NN cord-005453-4057qib7 3367 20 CI CI NNP cord-005453-4057qib7 3367 21 0.89 0.89 CD cord-005453-4057qib7 3367 22 - - HYPH cord-005453-4057qib7 3367 23 0.95 0.95 CD cord-005453-4057qib7 3367 24 . . . cord-005453-4057qib7 3368 1 In in IN cord-005453-4057qib7 3368 2 the the DT cord-005453-4057qib7 3368 3 training training NN cord-005453-4057qib7 3368 4 set set VBD cord-005453-4057qib7 3368 5 56.4 56.4 CD cord-005453-4057qib7 3368 6 % % NN cord-005453-4057qib7 3368 7 of of IN cord-005453-4057qib7 3368 8 pts pt NNS cord-005453-4057qib7 3368 9 using use VBG cord-005453-4057qib7 3368 10 opioids opioid NNS cord-005453-4057qib7 3368 11 were be VBD cord-005453-4057qib7 3368 12 correctly correctly RB cord-005453-4057qib7 3368 13 identified identify VBN cord-005453-4057qib7 3368 14 , , , cord-005453-4057qib7 3368 15 78.2 78.2 CD cord-005453-4057qib7 3368 16 % % NN cord-005453-4057qib7 3368 17 of of IN cord-005453-4057qib7 3368 18 those those DT cord-005453-4057qib7 3368 19 not not RB cord-005453-4057qib7 3368 20 taking take VBG cord-005453-4057qib7 3368 21 opioids opioid NNS cord-005453-4057qib7 3368 22 were be VBD cord-005453-4057qib7 3368 23 identified identify VBN cord-005453-4057qib7 3368 24 , , , cord-005453-4057qib7 3368 25 an an DT cord-005453-4057qib7 3368 26 overall overall JJ cord-005453-4057qib7 3368 27 fraction fraction NN cord-005453-4057qib7 3368 28 of of IN cord-005453-4057qib7 3368 29 correctly correctly RB cord-005453-4057qib7 3368 30 identified identify VBN cord-005453-4057qib7 3368 31 pts pts NNP cord-005453-4057qib7 3368 32 was be VBD cord-005453-4057qib7 3368 33 70.9 70.9 CD cord-005453-4057qib7 3368 34 % % NN cord-005453-4057qib7 3368 35 ( ( -LRB- cord-005453-4057qib7 3368 36 95 95 CD cord-005453-4057qib7 3368 37 % % NN cord-005453-4057qib7 3368 38 CI CI NNP cord-005453-4057qib7 3368 39 63.3 63.3 CD cord-005453-4057qib7 3368 40 -77.7 -77.7 CD cord-005453-4057qib7 3368 41 % % NN cord-005453-4057qib7 3368 42 ) ) -RRB- cord-005453-4057qib7 3368 43 , , , cord-005453-4057qib7 3368 44 while while IN cord-005453-4057qib7 3368 45 in in IN cord-005453-4057qib7 3368 46 the the DT cord-005453-4057qib7 3368 47 testing testing NN cord-005453-4057qib7 3368 48 set set VBN cord-005453-4057qib7 3368 49 , , , cord-005453-4057qib7 3368 50 45.5 45.5 CD cord-005453-4057qib7 3368 51 % % NN cord-005453-4057qib7 3368 52 of of IN cord-005453-4057qib7 3368 53 those those DT cord-005453-4057qib7 3368 54 using use VBG cord-005453-4057qib7 3368 55 opioids opioid NNS cord-005453-4057qib7 3368 56 were be VBD cord-005453-4057qib7 3368 57 correctly correctly RB cord-005453-4057qib7 3368 58 identified identify VBN cord-005453-4057qib7 3368 59 , , , cord-005453-4057qib7 3368 60 and and CC cord-005453-4057qib7 3368 61 67.9 67.9 CD cord-005453-4057qib7 3368 62 % % NN cord-005453-4057qib7 3368 63 of of IN cord-005453-4057qib7 3368 64 those those DT cord-005453-4057qib7 3368 65 not not RB cord-005453-4057qib7 3368 66 taking take VBG cord-005453-4057qib7 3368 67 opioids opioid NNS cord-005453-4057qib7 3368 68 were be VBD cord-005453-4057qib7 3368 69 correctly correctly RB cord-005453-4057qib7 3368 70 identified identify VBN cord-005453-4057qib7 3368 71 , , , cord-005453-4057qib7 3368 72 with with IN cord-005453-4057qib7 3368 73 overall overall JJ cord-005453-4057qib7 3368 74 60.5 60.5 CD cord-005453-4057qib7 3368 75 % % NN cord-005453-4057qib7 3368 76 ( ( -LRB- cord-005453-4057qib7 3368 77 95 95 CD cord-005453-4057qib7 3368 78 % % NN cord-005453-4057qib7 3368 79 CI ci NN cord-005453-4057qib7 3368 80 : : : cord-005453-4057qib7 3368 81 52.6 52.6 CD cord-005453-4057qib7 3368 82 - - HYPH cord-005453-4057qib7 3368 83 68.0 68.0 CD cord-005453-4057qib7 3368 84 % % NN cord-005453-4057qib7 3368 85 ) ) -RRB- cord-005453-4057qib7 3368 86 classification classification NN cord-005453-4057qib7 3368 87 accuracy accuracy NN cord-005453-4057qib7 3368 88 . . . cord-005453-4057qib7 3369 1 Conclusions conclusion NNS cord-005453-4057qib7 3369 2 : : : cord-005453-4057qib7 3370 1 This this DT cord-005453-4057qib7 3370 2 study study NN cord-005453-4057qib7 3370 3 showed show VBD cord-005453-4057qib7 3370 4 the the DT cord-005453-4057qib7 3370 5 burden burden NN cord-005453-4057qib7 3370 6 of of IN cord-005453-4057qib7 3370 7 OA OA NNP cord-005453-4057qib7 3370 8 in in IN cord-005453-4057qib7 3370 9 this this DT cord-005453-4057qib7 3370 10 cGVHD cGVHD NNP cord-005453-4057qib7 3370 11 cohort cohort NN cord-005453-4057qib7 3370 12 . . . cord-005453-4057qib7 3371 1 Lower low JJR cord-005453-4057qib7 3371 2 KPS KPS NNP cord-005453-4057qib7 3371 3 was be VBD cord-005453-4057qib7 3371 4 significantly significantly RB cord-005453-4057qib7 3371 5 associated associate VBN cord-005453-4057qib7 3371 6 with with IN cord-005453-4057qib7 3371 7 OA OA NNP cord-005453-4057qib7 3371 8 use use NN cord-005453-4057qib7 3371 9 , , , cord-005453-4057qib7 3371 10 as as RB cord-005453-4057qib7 3371 11 well well RB cord-005453-4057qib7 3371 12 as as IN cord-005453-4057qib7 3371 13 self self NN cord-005453-4057qib7 3371 14 - - HYPH cord-005453-4057qib7 3371 15 reported report VBN cord-005453-4057qib7 3371 16 symptoms symptom NNS cord-005453-4057qib7 3371 17 and and CC cord-005453-4057qib7 3371 18 a a DT cord-005453-4057qib7 3371 19 more more RBR cord-005453-4057qib7 3371 20 severe severe JJ cord-005453-4057qib7 3371 21 cGVHD cgvhd NN cord-005453-4057qib7 3371 22 disease disease NN cord-005453-4057qib7 3371 23 , , , cord-005453-4057qib7 3371 24 which which WDT cord-005453-4057qib7 3371 25 could could MD cord-005453-4057qib7 3371 26 be be VB cord-005453-4057qib7 3371 27 of of IN cord-005453-4057qib7 3371 28 interest interest NN cord-005453-4057qib7 3371 29 in in IN cord-005453-4057qib7 3371 30 the the DT cord-005453-4057qib7 3371 31 development development NN cord-005453-4057qib7 3371 32 of of IN cord-005453-4057qib7 3371 33 non non JJ cord-005453-4057qib7 3371 34 - - JJ cord-005453-4057qib7 3371 35 pharmaceutical pharmaceutical JJ cord-005453-4057qib7 3371 36 interventions intervention NNS cord-005453-4057qib7 3371 37 in in IN cord-005453-4057qib7 3371 38 this this DT cord-005453-4057qib7 3371 39 patient patient JJ cord-005453-4057qib7 3371 40 population population NN cord-005453-4057qib7 3371 41 . . . cord-005453-4057qib7 3372 1 Additional additional JJ cord-005453-4057qib7 3372 2 , , , cord-005453-4057qib7 3372 3 prospective prospective JJ cord-005453-4057qib7 3372 4 studies study NNS cord-005453-4057qib7 3372 5 are be VBP cord-005453-4057qib7 3372 6 needed need VBN cord-005453-4057qib7 3372 7 to to TO cord-005453-4057qib7 3372 8 explore explore VB cord-005453-4057qib7 3372 9 the the DT cord-005453-4057qib7 3372 10 indications indication NNS cord-005453-4057qib7 3372 11 for for IN cord-005453-4057qib7 3372 12 and and CC cord-005453-4057qib7 3372 13 effectiveness effectiveness NN cord-005453-4057qib7 3372 14 of of IN cord-005453-4057qib7 3372 15 OA OA NNP cord-005453-4057qib7 3372 16 in in IN cord-005453-4057qib7 3372 17 this this DT cord-005453-4057qib7 3372 18 population population NN cord-005453-4057qib7 3372 19 of of IN cord-005453-4057qib7 3372 20 survivors survivor NNS cord-005453-4057qib7 3372 21 . . . cord-005453-4057qib7 3373 1 Disclosure disclosure NN cord-005453-4057qib7 3373 2 : : : cord-005453-4057qib7 3374 1 No no DT cord-005453-4057qib7 3374 2 conflict conflict NN cord-005453-4057qib7 3374 3 of of IN cord-005453-4057qib7 3374 4 interest interest NN cord-005453-4057qib7 3374 5 to to TO cord-005453-4057qib7 3374 6 declare declare VB cord-005453-4057qib7 3374 7 . . . cord-005453-4057qib7 3375 1 RCTs RCTs NNP cord-005453-4057qib7 3375 2 that that WDT cord-005453-4057qib7 3375 3 tested test VBD cord-005453-4057qib7 3375 4 an an DT cord-005453-4057qib7 3375 5 internet internet NN cord-005453-4057qib7 3375 6 - - HYPH cord-005453-4057qib7 3375 7 based base VBN cord-005453-4057qib7 3375 8 program program NN cord-005453-4057qib7 3375 9 and and CC cord-005453-4057qib7 3375 10 patientcentered patientcentered JJ cord-005453-4057qib7 3375 11 survivorship survivorship NN cord-005453-4057qib7 3375 12 care care NN cord-005453-4057qib7 3375 13 plans plan NNS cord-005453-4057qib7 3375 14 for for IN cord-005453-4057qib7 3375 15 HCT hct NN cord-005453-4057qib7 3375 16 survivors survivor NNS cord-005453-4057qib7 3375 17 . . . cord-005453-4057qib7 3376 1 Patient patient JJ cord-005453-4057qib7 3376 2 and and CC cord-005453-4057qib7 3376 3 caregiver caregiver NN cord-005453-4057qib7 3376 4 input input NN cord-005453-4057qib7 3376 5 is be VBZ cord-005453-4057qib7 3376 6 essential essential JJ cord-005453-4057qib7 3376 7 to to TO cord-005453-4057qib7 3376 8 inform inform VB cord-005453-4057qib7 3376 9 the the DT cord-005453-4057qib7 3376 10 design design NN cord-005453-4057qib7 3376 11 and and CC cord-005453-4057qib7 3376 12 features feature VBZ cord-005453-4057qib7 3376 13 for for IN cord-005453-4057qib7 3376 14 the the DT cord-005453-4057qib7 3376 15 mobile mobile JJ cord-005453-4057qib7 3376 16 app app NN cord-005453-4057qib7 3376 17 platform platform NN cord-005453-4057qib7 3376 18 so so IN cord-005453-4057qib7 3376 19 that that IN cord-005453-4057qib7 3376 20 it -PRON- PRP cord-005453-4057qib7 3376 21 is be VBZ cord-005453-4057qib7 3376 22 usable usable JJ cord-005453-4057qib7 3376 23 and and CC cord-005453-4057qib7 3376 24 engaging engaging JJ cord-005453-4057qib7 3376 25 for for IN cord-005453-4057qib7 3376 26 those those DT cord-005453-4057qib7 3376 27 it -PRON- PRP cord-005453-4057qib7 3376 28 targets target VBZ cord-005453-4057qib7 3376 29 . . . cord-005453-4057qib7 3377 1 Methods method NNS cord-005453-4057qib7 3377 2 : : : cord-005453-4057qib7 3377 3 Using use VBG cord-005453-4057qib7 3377 4 a a DT cord-005453-4057qib7 3377 5 qualitative qualitative JJ cord-005453-4057qib7 3377 6 research research NN cord-005453-4057qib7 3377 7 design design NN cord-005453-4057qib7 3377 8 , , , cord-005453-4057qib7 3377 9 we -PRON- PRP cord-005453-4057qib7 3377 10 conducted conduct VBD cord-005453-4057qib7 3377 11 telephone telephone NN cord-005453-4057qib7 3377 12 focus focus NN cord-005453-4057qib7 3377 13 groups group NNS cord-005453-4057qib7 3377 14 of of IN cord-005453-4057qib7 3377 15 adult adult NN cord-005453-4057qib7 3377 16 patients patient NNS cord-005453-4057qib7 3377 17 and and CC cord-005453-4057qib7 3377 18 caregivers caregiver NNS cord-005453-4057qib7 3377 19 in in IN cord-005453-4057qib7 3377 20 the the DT cord-005453-4057qib7 3377 21 United United NNP cord-005453-4057qib7 3377 22 States States NNP cord-005453-4057qib7 3377 23 . . . cord-005453-4057qib7 3378 1 Adult adult NN cord-005453-4057qib7 3378 2 ( ( -LRB- cord-005453-4057qib7 3378 3 age age NN cord-005453-4057qib7 3378 4 > > XX cord-005453-4057qib7 3378 5 18 18 CD cord-005453-4057qib7 3378 6 years year NNS cord-005453-4057qib7 3378 7 at at IN cord-005453-4057qib7 3378 8 the the DT cord-005453-4057qib7 3378 9 time time NN cord-005453-4057qib7 3378 10 of of IN cord-005453-4057qib7 3378 11 study study NN cord-005453-4057qib7 3378 12 entry entry NN cord-005453-4057qib7 3378 13 ) ) -RRB- cord-005453-4057qib7 3379 1 HCT HCT NNP cord-005453-4057qib7 3379 2 recipients recipient NNS cord-005453-4057qib7 3379 3 had have VBD cord-005453-4057qib7 3379 4 to to TO cord-005453-4057qib7 3379 5 be be VB cord-005453-4057qib7 3379 6 at at IN cord-005453-4057qib7 3379 7 least least JJS cord-005453-4057qib7 3379 8 oneyear oneyear JJ cord-005453-4057qib7 3379 9 post post NN cord-005453-4057qib7 3379 10 - - JJ cord-005453-4057qib7 3379 11 HCT HCT NNP cord-005453-4057qib7 3379 12 to to TO cord-005453-4057qib7 3379 13 participate participate VB cord-005453-4057qib7 3379 14 . . . cord-005453-4057qib7 3380 1 Participants participant NNS cord-005453-4057qib7 3380 2 had have VBD cord-005453-4057qib7 3380 3 to to TO cord-005453-4057qib7 3380 4 be be VB cord-005453-4057qib7 3380 5 able able JJ cord-005453-4057qib7 3380 6 to to TO cord-005453-4057qib7 3380 7 communicate communicate VB cord-005453-4057qib7 3380 8 in in IN cord-005453-4057qib7 3380 9 English English NNP cord-005453-4057qib7 3380 10 , , , cord-005453-4057qib7 3380 11 and and CC cord-005453-4057qib7 3380 12 could could MD cord-005453-4057qib7 3380 13 have have VB cord-005453-4057qib7 3380 14 received receive VBN cord-005453-4057qib7 3380 15 a a DT cord-005453-4057qib7 3380 16 HCT hct NN cord-005453-4057qib7 3380 17 for for IN cord-005453-4057qib7 3380 18 any any DT cord-005453-4057qib7 3380 19 diagnosis diagnosis NN cord-005453-4057qib7 3380 20 , , , cord-005453-4057qib7 3380 21 and and CC cord-005453-4057qib7 3380 22 from from IN cord-005453-4057qib7 3380 23 any any DT cord-005453-4057qib7 3380 24 donor donor NN cord-005453-4057qib7 3380 25 source source NN cord-005453-4057qib7 3380 26 or or CC cord-005453-4057qib7 3380 27 stem stem NN cord-005453-4057qib7 3380 28 cell cell NN cord-005453-4057qib7 3380 29 type type NN cord-005453-4057qib7 3380 30 . . . cord-005453-4057qib7 3381 1 Those those DT cord-005453-4057qib7 3381 2 who who WP cord-005453-4057qib7 3381 3 had have VBD cord-005453-4057qib7 3381 4 multiple multiple JJ cord-005453-4057qib7 3381 5 transplants transplant NNS cord-005453-4057qib7 3381 6 were be VBD cord-005453-4057qib7 3381 7 included include VBN cord-005453-4057qib7 3381 8 . . . cord-005453-4057qib7 3382 1 Participants participant NNS cord-005453-4057qib7 3382 2 were be VBD cord-005453-4057qib7 3382 3 asked ask VBN cord-005453-4057qib7 3382 4 to to TO cord-005453-4057qib7 3382 5 review review VB cord-005453-4057qib7 3382 6 printed print VBN cord-005453-4057qib7 3382 7 and and CC cord-005453-4057qib7 3382 8 online online JJ cord-005453-4057qib7 3382 9 visual visual JJ cord-005453-4057qib7 3382 10 presentations presentation NNS cord-005453-4057qib7 3382 11 of of IN cord-005453-4057qib7 3382 12 the the DT cord-005453-4057qib7 3382 13 mobile mobile JJ cord-005453-4057qib7 3382 14 app app NN cord-005453-4057qib7 3382 15 before before IN cord-005453-4057qib7 3382 16 the the DT cord-005453-4057qib7 3382 17 focus focus NN cord-005453-4057qib7 3382 18 groups group NNS cord-005453-4057qib7 3383 1 so so RB cord-005453-4057qib7 3383 2 they -PRON- PRP cord-005453-4057qib7 3383 3 were be VBD cord-005453-4057qib7 3383 4 prepared prepared JJ cord-005453-4057qib7 3383 5 to to TO cord-005453-4057qib7 3383 6 discuss discuss VB cord-005453-4057qib7 3383 7 their -PRON- PRP$ cord-005453-4057qib7 3383 8 responses response NNS cord-005453-4057qib7 3383 9 to to IN cord-005453-4057qib7 3383 10 the the DT cord-005453-4057qib7 3383 11 materials material NNS cord-005453-4057qib7 3383 12 during during IN cord-005453-4057qib7 3383 13 the the DT cord-005453-4057qib7 3383 14 call call NN cord-005453-4057qib7 3383 15 . . . cord-005453-4057qib7 3384 1 Focus focus JJ cord-005453-4057qib7 3384 2 groups group NNS cord-005453-4057qib7 3384 3 were be VBD cord-005453-4057qib7 3384 4 conducted conduct VBN cord-005453-4057qib7 3384 5 to to IN cord-005453-4057qib7 3384 6 saturation saturation NN cord-005453-4057qib7 3384 7 , , , cord-005453-4057qib7 3384 8 when when WRB cord-005453-4057qib7 3384 9 no no DT cord-005453-4057qib7 3384 10 new new JJ cord-005453-4057qib7 3384 11 qualitative qualitative JJ cord-005453-4057qib7 3384 12 content content NN cord-005453-4057qib7 3384 13 was be VBD cord-005453-4057qib7 3384 14 offered offer VBN cord-005453-4057qib7 3384 15 . . . cord-005453-4057qib7 3385 1 Results result NNS cord-005453-4057qib7 3385 2 : : : cord-005453-4057qib7 3386 1 Three three CD cord-005453-4057qib7 3386 2 focus focus NN cord-005453-4057qib7 3386 3 groups group NNS cord-005453-4057qib7 3386 4 were be VBD cord-005453-4057qib7 3386 5 conducted conduct VBN cord-005453-4057qib7 3386 6 with with IN cord-005453-4057qib7 3386 7 22 22 CD cord-005453-4057qib7 3386 8 total total JJ cord-005453-4057qib7 3386 9 participants participant NNS cord-005453-4057qib7 3386 10 ( ( -LRB- cord-005453-4057qib7 3386 11 20 20 CD cord-005453-4057qib7 3386 12 patients patient NNS cord-005453-4057qib7 3386 13 , , , cord-005453-4057qib7 3386 14 two two CD cord-005453-4057qib7 3386 15 caregivers caregiver NNS cord-005453-4057qib7 3386 16 / / SYM cord-005453-4057qib7 3386 17 patient patient NN cord-005453-4057qib7 3386 18 advocates advocate NNS cord-005453-4057qib7 3386 19 ) ) -RRB- cord-005453-4057qib7 3386 20 . . . cord-005453-4057qib7 3387 1 All all DT cord-005453-4057qib7 3387 2 patients patient NNS cord-005453-4057qib7 3387 3 received receive VBD cord-005453-4057qib7 3387 4 an an DT cord-005453-4057qib7 3387 5 allogeneic allogeneic NN cord-005453-4057qib7 3387 6 HCT hct NN cord-005453-4057qib7 3387 7 ; ; : cord-005453-4057qib7 3387 8 average average JJ cord-005453-4057qib7 3387 9 time time NN cord-005453-4057qib7 3387 10 since since IN cord-005453-4057qib7 3387 11 HCT HCT NNP cord-005453-4057qib7 3387 12 was be VBD cord-005453-4057qib7 3387 13 8 8 CD cord-005453-4057qib7 3387 14 years year NNS cord-005453-4057qib7 3387 15 ( ( -LRB- cord-005453-4057qib7 3387 16 range range NN cord-005453-4057qib7 3387 17 : : : cord-005453-4057qib7 3387 18 2 2 CD cord-005453-4057qib7 3387 19 - - SYM cord-005453-4057qib7 3387 20 22 22 CD cord-005453-4057qib7 3387 21 years).The years).The NNP cord-005453-4057qib7 3387 22 majority majority NN cord-005453-4057qib7 3387 23 of of IN cord-005453-4057qib7 3387 24 participants participant NNS cord-005453-4057qib7 3387 25 were be VBD cord-005453-4057qib7 3387 26 female female JJ cord-005453-4057qib7 3387 27 ( ( -LRB- cord-005453-4057qib7 3387 28 77.3 77.3 CD cord-005453-4057qib7 3387 29 % % NN cord-005453-4057qib7 3387 30 ) ) -RRB- cord-005453-4057qib7 3387 31 . . . cord-005453-4057qib7 3388 1 Participants participant NNS cord-005453-4057qib7 3388 2 had have VBD cord-005453-4057qib7 3388 3 differing differ VBG cord-005453-4057qib7 3388 4 perspectives perspective NNS cord-005453-4057qib7 3388 5 on on IN cord-005453-4057qib7 3388 6 the the DT cord-005453-4057qib7 3388 7 usefulness usefulness NN cord-005453-4057qib7 3388 8 of of IN cord-005453-4057qib7 3388 9 the the DT cord-005453-4057qib7 3388 10 app app NN cord-005453-4057qib7 3388 11 to to TO cord-005453-4057qib7 3388 12 track track VB cord-005453-4057qib7 3388 13 follow follow VB cord-005453-4057qib7 3388 14 - - HYPH cord-005453-4057qib7 3388 15 up up RP cord-005453-4057qib7 3388 16 appointments appointment NNS cord-005453-4057qib7 3388 17 , , , cord-005453-4057qib7 3388 18 lab lab NN cord-005453-4057qib7 3388 19 values value NNS cord-005453-4057qib7 3388 20 , , , cord-005453-4057qib7 3388 21 and and CC cord-005453-4057qib7 3388 22 other other JJ cord-005453-4057qib7 3388 23 health health NN cord-005453-4057qib7 3388 24 care care NN cord-005453-4057qib7 3388 25 plans plan NNS cord-005453-4057qib7 3388 26 . . . cord-005453-4057qib7 3389 1 There there EX cord-005453-4057qib7 3389 2 was be VBD cord-005453-4057qib7 3389 3 high high JJ cord-005453-4057qib7 3389 4 interest interest NN cord-005453-4057qib7 3389 5 in in IN cord-005453-4057qib7 3389 6 having have VBG cord-005453-4057qib7 3389 7 the the DT cord-005453-4057qib7 3389 8 app app NN cord-005453-4057qib7 3389 9 tailored tailor VBN cord-005453-4057qib7 3389 10 to to TO cord-005453-4057qib7 3389 11 meet meet VB cord-005453-4057qib7 3389 12 specific specific JJ cord-005453-4057qib7 3389 13 needs need NNS cord-005453-4057qib7 3389 14 of of IN cord-005453-4057qib7 3389 15 patients patient NNS cord-005453-4057qib7 3389 16 , , , cord-005453-4057qib7 3389 17 including include VBG cord-005453-4057qib7 3389 18 tracking track VBG cord-005453-4057qib7 3389 19 information information NN cord-005453-4057qib7 3389 20 over over IN cord-005453-4057qib7 3389 21 time time NN cord-005453-4057qib7 3389 22 ( ( -LRB- cord-005453-4057qib7 3389 23 e.g. e.g. IN cord-005453-4057qib7 3389 24 test test NN cord-005453-4057qib7 3389 25 results result NNS cord-005453-4057qib7 3389 26 , , , cord-005453-4057qib7 3389 27 medications medication NNS cord-005453-4057qib7 3389 28 ) ) -RRB- cord-005453-4057qib7 3389 29 , , , cord-005453-4057qib7 3389 30 and and CC cord-005453-4057qib7 3389 31 having have VBG cord-005453-4057qib7 3389 32 health health NN cord-005453-4057qib7 3389 33 information information NN cord-005453-4057qib7 3389 34 available available JJ cord-005453-4057qib7 3389 35 specific specific JJ cord-005453-4057qib7 3389 36 to to IN cord-005453-4057qib7 3389 37 their -PRON- PRP$ cord-005453-4057qib7 3389 38 needs need NNS cord-005453-4057qib7 3389 39 . . . cord-005453-4057qib7 3390 1 To to TO cord-005453-4057qib7 3390 2 minimize minimize VB cord-005453-4057qib7 3390 3 duplication duplication NN cord-005453-4057qib7 3390 4 of of IN cord-005453-4057qib7 3390 5 information information NN cord-005453-4057qib7 3390 6 and and CC cord-005453-4057qib7 3390 7 data datum NNS cord-005453-4057qib7 3390 8 entry entry NN cord-005453-4057qib7 3390 9 , , , cord-005453-4057qib7 3390 10 participants participant NNS cord-005453-4057qib7 3390 11 recommended recommend VBD cord-005453-4057qib7 3390 12 syncing sync VBG cord-005453-4057qib7 3390 13 the the DT cord-005453-4057qib7 3390 14 app app NN cord-005453-4057qib7 3390 15 with with IN cord-005453-4057qib7 3390 16 their -PRON- PRP$ cord-005453-4057qib7 3390 17 calendars calendar NNS cord-005453-4057qib7 3390 18 and and CC cord-005453-4057qib7 3390 19 online online JJ cord-005453-4057qib7 3390 20 patient patient NN cord-005453-4057qib7 3390 21 portals portal NNS cord-005453-4057qib7 3390 22 they -PRON- PRP cord-005453-4057qib7 3390 23 already already RB cord-005453-4057qib7 3390 24 use use VBP cord-005453-4057qib7 3390 25 . . . cord-005453-4057qib7 3391 1 Reasons reason NNS cord-005453-4057qib7 3391 2 provided provide VBN cord-005453-4057qib7 3391 3 for for IN cord-005453-4057qib7 3391 4 not not RB cord-005453-4057qib7 3391 5 using use VBG cord-005453-4057qib7 3391 6 the the DT cord-005453-4057qib7 3391 7 app app NN cord-005453-4057qib7 3391 8 included include VBD cord-005453-4057qib7 3391 9 perception perception NN cord-005453-4057qib7 3391 10 that that IN cord-005453-4057qib7 3391 11 the the DT cord-005453-4057qib7 3391 12 materials material NNS cord-005453-4057qib7 3391 13 repeated repeat VBD cord-005453-4057qib7 3391 14 information information NN cord-005453-4057qib7 3391 15 already already RB cord-005453-4057qib7 3391 16 received receive VBN cord-005453-4057qib7 3391 17 , , , cord-005453-4057qib7 3391 18 side side NN cord-005453-4057qib7 3391 19 effects effect NNS cord-005453-4057qib7 3391 20 such such JJ cord-005453-4057qib7 3391 21 as as IN cord-005453-4057qib7 3391 22 graft graft NN cord-005453-4057qib7 3391 23 - - HYPH cord-005453-4057qib7 3391 24 versus versus IN cord-005453-4057qib7 3391 25 - - HYPH cord-005453-4057qib7 3391 26 host host NN cord-005453-4057qib7 3391 27 disease disease NN cord-005453-4057qib7 3391 28 that that WDT cord-005453-4057qib7 3391 29 restricted restrict VBD cord-005453-4057qib7 3391 30 vision vision NN cord-005453-4057qib7 3391 31 or or CC cord-005453-4057qib7 3391 32 motor motor NN cord-005453-4057qib7 3391 33 skills skill NNS cord-005453-4057qib7 3391 34 , , , cord-005453-4057qib7 3391 35 and and CC cord-005453-4057qib7 3391 36 lack lack NN cord-005453-4057qib7 3391 37 of of IN cord-005453-4057qib7 3391 38 comfort comfort NN cord-005453-4057qib7 3391 39 with with IN cord-005453-4057qib7 3391 40 apps app NNS cord-005453-4057qib7 3391 41 for for IN cord-005453-4057qib7 3391 42 some some DT cord-005453-4057qib7 3391 43 older old JJR cord-005453-4057qib7 3391 44 participants participant NNS cord-005453-4057qib7 3391 45 . . . cord-005453-4057qib7 3392 1 Conclusions conclusion NNS cord-005453-4057qib7 3392 2 : : : cord-005453-4057qib7 3393 1 Many many JJ cord-005453-4057qib7 3393 2 health health NN cord-005453-4057qib7 3393 3 technology technology NN cord-005453-4057qib7 3393 4 and and CC cord-005453-4057qib7 3393 5 mobile mobile JJ cord-005453-4057qib7 3393 6 apps app NNS cord-005453-4057qib7 3393 7 are be VBP cord-005453-4057qib7 3393 8 being be VBG cord-005453-4057qib7 3393 9 created create VBN cord-005453-4057qib7 3393 10 to to TO cord-005453-4057qib7 3393 11 improve improve VB cord-005453-4057qib7 3393 12 patients patient NNS cord-005453-4057qib7 3393 13 ' ' POS cord-005453-4057qib7 3393 14 health health NN cord-005453-4057qib7 3393 15 and and CC cord-005453-4057qib7 3393 16 survivorship survivorship NN cord-005453-4057qib7 3393 17 care care NN cord-005453-4057qib7 3393 18 . . . cord-005453-4057qib7 3394 1 In in IN cord-005453-4057qib7 3394 2 this this DT cord-005453-4057qib7 3394 3 study study NN cord-005453-4057qib7 3394 4 , , , cord-005453-4057qib7 3394 5 HCT HCT NNP cord-005453-4057qib7 3394 6 survivors survivor NNS cord-005453-4057qib7 3394 7 and and CC cord-005453-4057qib7 3394 8 caregivers caregiver NNS cord-005453-4057qib7 3394 9 identified identify VBD cord-005453-4057qib7 3394 10 a a DT cord-005453-4057qib7 3394 11 variety variety NN cord-005453-4057qib7 3394 12 of of IN cord-005453-4057qib7 3394 13 features feature NNS cord-005453-4057qib7 3394 14 that that WDT cord-005453-4057qib7 3394 15 they -PRON- PRP cord-005453-4057qib7 3394 16 would would MD cord-005453-4057qib7 3394 17 want want VB cord-005453-4057qib7 3394 18 in in IN cord-005453-4057qib7 3394 19 an an DT cord-005453-4057qib7 3394 20 app app NN cord-005453-4057qib7 3394 21 or or CC cord-005453-4057qib7 3394 22 website website NN cord-005453-4057qib7 3394 23 , , , cord-005453-4057qib7 3394 24 in in IN cord-005453-4057qib7 3394 25 particular particular JJ cord-005453-4057qib7 3394 26 , , , cord-005453-4057qib7 3394 27 features feature VBZ cord-005453-4057qib7 3394 28 tailored tailor VBN cord-005453-4057qib7 3394 29 to to IN cord-005453-4057qib7 3394 30 individual individual JJ cord-005453-4057qib7 3394 31 needs need NNS cord-005453-4057qib7 3394 32 . . . cord-005453-4057qib7 3395 1 Health health NN cord-005453-4057qib7 3395 2 technologies technology NNS cord-005453-4057qib7 3395 3 provide provide VBP cord-005453-4057qib7 3395 4 an an DT cord-005453-4057qib7 3395 5 opportunity opportunity NN cord-005453-4057qib7 3395 6 to to TO cord-005453-4057qib7 3395 7 improve improve VB cord-005453-4057qib7 3395 8 survivorship survivorship NN cord-005453-4057qib7 3395 9 care care NN cord-005453-4057qib7 3395 10 , , , cord-005453-4057qib7 3395 11 but but CC cord-005453-4057qib7 3395 12 patients patient NNS cord-005453-4057qib7 3395 13 and and CC cord-005453-4057qib7 3395 14 caregivers caregiver NNS cord-005453-4057qib7 3395 15 should should MD cord-005453-4057qib7 3395 16 be be VB cord-005453-4057qib7 3395 17 engaged engage VBN cord-005453-4057qib7 3395 18 in in IN cord-005453-4057qib7 3395 19 the the DT cord-005453-4057qib7 3395 20 process process NN cord-005453-4057qib7 3395 21 of of IN cord-005453-4057qib7 3395 22 developing develop VBG cord-005453-4057qib7 3395 23 these these DT cord-005453-4057qib7 3395 24 tools tool NNS cord-005453-4057qib7 3395 25 to to TO cord-005453-4057qib7 3395 26 assure assure VB cord-005453-4057qib7 3395 27 the the DT cord-005453-4057qib7 3395 28 technology technology NN cord-005453-4057qib7 3395 29 fits fit VBZ cord-005453-4057qib7 3395 30 their -PRON- PRP$ cord-005453-4057qib7 3395 31 needs need NNS cord-005453-4057qib7 3395 32 and and CC cord-005453-4057qib7 3395 33 will will MD cord-005453-4057qib7 3395 34 be be VB cord-005453-4057qib7 3395 35 used use VBN cord-005453-4057qib7 3395 36 . . . cord-005453-4057qib7 3396 1 Given give VBN cord-005453-4057qib7 3396 2 the the DT cord-005453-4057qib7 3396 3 effort effort NN cord-005453-4057qib7 3396 4 required require VBN cord-005453-4057qib7 3396 5 to to TO cord-005453-4057qib7 3396 6 maintain maintain VB cord-005453-4057qib7 3396 7 these these DT cord-005453-4057qib7 3396 8 technologies technology NNS cord-005453-4057qib7 3396 9 , , , cord-005453-4057qib7 3396 10 they -PRON- PRP cord-005453-4057qib7 3396 11 require require VBP cord-005453-4057qib7 3396 12 testing testing NN cord-005453-4057qib7 3396 13 for for IN cord-005453-4057qib7 3396 14 health health NN cord-005453-4057qib7 3396 15 benefits benefit NNS cord-005453-4057qib7 3396 16 in in IN cord-005453-4057qib7 3396 17 rigorous rigorous JJ cord-005453-4057qib7 3396 18 clinical clinical JJ cord-005453-4057qib7 3396 19 trials trial NNS cord-005453-4057qib7 3396 20 . . . cord-005453-4057qib7 3397 1 Clinical clinical JJ cord-005453-4057qib7 3397 2 Background background NN cord-005453-4057qib7 3397 3 : : : cord-005453-4057qib7 3398 1 Thanks thank NNS cord-005453-4057qib7 3398 2 to to IN cord-005453-4057qib7 3399 1 allogeneic allogeneic IN cord-005453-4057qib7 3399 2 stem stem NN cord-005453-4057qib7 3399 3 cell cell NN cord-005453-4057qib7 3399 4 transplantation transplantation NN cord-005453-4057qib7 3399 5 ( ( -LRB- cord-005453-4057qib7 3399 6 allo allo NN cord-005453-4057qib7 3399 7 - - HYPH cord-005453-4057qib7 3399 8 HSCT HSCT NNP cord-005453-4057qib7 3399 9 ) ) -RRB- cord-005453-4057qib7 3399 10 patients patient NNS cord-005453-4057qib7 3399 11 suffering suffer VBG cord-005453-4057qib7 3399 12 from from IN cord-005453-4057qib7 3399 13 hematologic hematologic JJ cord-005453-4057qib7 3399 14 malignancies malignancy NNS cord-005453-4057qib7 3399 15 have have VBP cord-005453-4057qib7 3399 16 seen see VBN cord-005453-4057qib7 3399 17 an an DT cord-005453-4057qib7 3399 18 increase increase NN cord-005453-4057qib7 3399 19 in in IN cord-005453-4057qib7 3399 20 there there RB cord-005453-4057qib7 3399 21 life life NN cord-005453-4057qib7 3399 22 duration duration NN cord-005453-4057qib7 3399 23 expectancy expectancy NN cord-005453-4057qib7 3399 24 , , , cord-005453-4057qib7 3399 25 but but CC cord-005453-4057qib7 3399 26 they -PRON- PRP cord-005453-4057qib7 3399 27 are be VBP cord-005453-4057qib7 3399 28 many many JJ cord-005453-4057qib7 3399 29 side side NN cord-005453-4057qib7 3399 30 effets effet NNS cord-005453-4057qib7 3399 31 including include VBG cord-005453-4057qib7 3399 32 decreasing decrease VBG cord-005453-4057qib7 3399 33 in in IN cord-005453-4057qib7 3399 34 physical physical JJ cord-005453-4057qib7 3399 35 performance performance NN cord-005453-4057qib7 3399 36 and and CC cord-005453-4057qib7 3399 37 in in IN cord-005453-4057qib7 3399 38 quality quality NN cord-005453-4057qib7 3399 39 of of IN cord-005453-4057qib7 3399 40 life life NN cord-005453-4057qib7 3399 41 . . . cord-005453-4057qib7 3400 1 The the DT cord-005453-4057qib7 3400 2 intensity intensity NN cord-005453-4057qib7 3400 3 of of IN cord-005453-4057qib7 3400 4 physical physical JJ cord-005453-4057qib7 3400 5 performance performance NN cord-005453-4057qib7 3400 6 decrease decrease NN cord-005453-4057qib7 3400 7 is be VBZ cord-005453-4057qib7 3400 8 variable variable JJ cord-005453-4057qib7 3400 9 between between IN cord-005453-4057qib7 3400 10 patients patient NNS cord-005453-4057qib7 3400 11 , , , cord-005453-4057qib7 3400 12 and and CC cord-005453-4057qib7 3400 13 today today NN cord-005453-4057qib7 3400 14 we -PRON- PRP cord-005453-4057qib7 3400 15 did do VBD cord-005453-4057qib7 3400 16 not not RB cord-005453-4057qib7 3400 17 know know VB cord-005453-4057qib7 3400 18 why why WRB cord-005453-4057qib7 3400 19 . . . cord-005453-4057qib7 3401 1 The the DT cord-005453-4057qib7 3401 2 aim aim NN cord-005453-4057qib7 3401 3 of of IN cord-005453-4057qib7 3401 4 our -PRON- PRP$ cord-005453-4057qib7 3401 5 study study NN cord-005453-4057qib7 3401 6 was be VBD cord-005453-4057qib7 3401 7 first first JJ cord-005453-4057qib7 3401 8 to to TO cord-005453-4057qib7 3401 9 characterize characterize VB cord-005453-4057qib7 3401 10 the the DT cord-005453-4057qib7 3401 11 physical physical JJ cord-005453-4057qib7 3401 12 performance performance NN cord-005453-4057qib7 3401 13 of of IN cord-005453-4057qib7 3401 14 subjects subject NNS cord-005453-4057qib7 3401 15 less less JJR cord-005453-4057qib7 3401 16 than than IN cord-005453-4057qib7 3401 17 1 1 CD cord-005453-4057qib7 3401 18 year year NN cord-005453-4057qib7 3401 19 following follow VBG cord-005453-4057qib7 3401 20 allo allo NN cord-005453-4057qib7 3401 21 - - HYPH cord-005453-4057qib7 3401 22 HSCT HSCT NNP cord-005453-4057qib7 3401 23 by by IN cord-005453-4057qib7 3401 24 the the DT cord-005453-4057qib7 3401 25 use use NN cord-005453-4057qib7 3401 26 of of IN cord-005453-4057qib7 3401 27 a a DT cord-005453-4057qib7 3401 28 cardiopulmonary cardiopulmonary JJ cord-005453-4057qib7 3401 29 exercise exercise NN cord-005453-4057qib7 3401 30 testing testing NN cord-005453-4057qib7 3401 31 ( ( -LRB- cord-005453-4057qib7 3401 32 CPET CPET NNP cord-005453-4057qib7 3401 33 ) ) -RRB- cord-005453-4057qib7 3401 34 , , , cord-005453-4057qib7 3401 35 and and CC cord-005453-4057qib7 3401 36 then then RB cord-005453-4057qib7 3401 37 to to TO cord-005453-4057qib7 3401 38 determine determine VB cord-005453-4057qib7 3401 39 the the DT cord-005453-4057qib7 3401 40 predictive predictive JJ cord-005453-4057qib7 3401 41 factors factor NNS cord-005453-4057qib7 3401 42 of of IN cord-005453-4057qib7 3401 43 exercise exercise NN cord-005453-4057qib7 3401 44 performance performance NN cord-005453-4057qib7 3401 45 . . . cord-005453-4057qib7 3402 1 Methods method NNS cord-005453-4057qib7 3402 2 : : : cord-005453-4057qib7 3402 3 We -PRON- PRP cord-005453-4057qib7 3402 4 did do VBD cord-005453-4057qib7 3402 5 a a DT cord-005453-4057qib7 3402 6 retrospective retrospective JJ cord-005453-4057qib7 3402 7 analysis analysis NN cord-005453-4057qib7 3402 8 from from IN cord-005453-4057qib7 3402 9 59 59 CD cord-005453-4057qib7 3402 10 patients patient NNS cord-005453-4057qib7 3402 11 who who WP cord-005453-4057qib7 3402 12 had have VBD cord-005453-4057qib7 3402 13 an an DT cord-005453-4057qib7 3402 14 allo allo NN cord-005453-4057qib7 3402 15 - - HYPH cord-005453-4057qib7 3402 16 HSCT HSCT NNP cord-005453-4057qib7 3402 17 at at IN cord-005453-4057qib7 3402 18 hematology hematology NN cord-005453-4057qib7 3402 19 department department NN cord-005453-4057qib7 3402 20 of of IN cord-005453-4057qib7 3402 21 Toulouse Toulouse NNP cord-005453-4057qib7 3402 22 - - HYPH cord-005453-4057qib7 3402 23 Oncopole Oncopole NNP cord-005453-4057qib7 3402 24 and and CC cord-005453-4057qib7 3402 25 CPET CPET NNP cord-005453-4057qib7 3402 26 from from IN cord-005453-4057qib7 3402 27 01/2015 01/2015 CD cord-005453-4057qib7 3402 28 to to IN cord-005453-4057qib7 3402 29 09/2017 09/2017 CD cord-005453-4057qib7 3402 30 . . . cord-005453-4057qib7 3403 1 The the DT cord-005453-4057qib7 3403 2 CPET CPET NNS cord-005453-4057qib7 3403 3 was be VBD cord-005453-4057qib7 3403 4 performed perform VBN cord-005453-4057qib7 3403 5 using use VBG cord-005453-4057qib7 3403 6 a a DT cord-005453-4057qib7 3403 7 cycle cycle NN cord-005453-4057qib7 3403 8 ergometer ergometer NN cord-005453-4057qib7 3403 9 with with IN cord-005453-4057qib7 3403 10 O2 O2 NNP cord-005453-4057qib7 3403 11 and and CC cord-005453-4057qib7 3403 12 CO2 CO2 NNP cord-005453-4057qib7 3403 13 analyzer analyzer NN cord-005453-4057qib7 3403 14 breath breath NN cord-005453-4057qib7 3403 15 by by IN cord-005453-4057qib7 3403 16 breath breath NN cord-005453-4057qib7 3403 17 , , , cord-005453-4057qib7 3403 18 ( ( -LRB- cord-005453-4057qib7 3403 19 Masterscreen Masterscreen NNP cord-005453-4057qib7 3403 20 CPX CPX NNP cord-005453-4057qib7 3403 21 CareFusion CareFusion NNP cord-005453-4057qib7 3403 22 , , , cord-005453-4057qib7 3403 23 San San NNP cord-005453-4057qib7 3403 24 Diego Diego NNP cord-005453-4057qib7 3403 25 , , , cord-005453-4057qib7 3403 26 USA USA NNP cord-005453-4057qib7 3403 27 ) ) -RRB- cord-005453-4057qib7 3403 28 , , , cord-005453-4057qib7 3403 29 a a DT cord-005453-4057qib7 3403 30 continuous continuous JJ cord-005453-4057qib7 3403 31 12-lead 12-lead JJ cord-005453-4057qib7 3403 32 electrocardiogram electrocardiogram NN cord-005453-4057qib7 3403 33 , , , cord-005453-4057qib7 3403 34 and and CC cord-005453-4057qib7 3403 35 a a DT cord-005453-4057qib7 3403 36 blood blood NN cord-005453-4057qib7 3403 37 pressure pressure NN cord-005453-4057qib7 3403 38 monitoring monitoring NN cord-005453-4057qib7 3403 39 . . . cord-005453-4057qib7 3404 1 The the DT cord-005453-4057qib7 3404 2 protocol protocol NN cord-005453-4057qib7 3404 3 included include VBD cord-005453-4057qib7 3404 4 a a DT cord-005453-4057qib7 3404 5 2-min 2-min JJ cord-005453-4057qib7 3404 6 rest rest NN cord-005453-4057qib7 3404 7 period period NN cord-005453-4057qib7 3404 8 , , , cord-005453-4057qib7 3404 9 a a DT cord-005453-4057qib7 3404 10 2-min 2-min JJ cord-005453-4057qib7 3404 11 warm warm NN cord-005453-4057qib7 3404 12 - - HYPH cord-005453-4057qib7 3404 13 up up NN cord-005453-4057qib7 3404 14 of of IN cord-005453-4057qib7 3404 15 20W 20w NN cord-005453-4057qib7 3404 16 pedaling pedaling NN cord-005453-4057qib7 3404 17 followed follow VBN cord-005453-4057qib7 3404 18 by by IN cord-005453-4057qib7 3404 19 a a DT cord-005453-4057qib7 3404 20 10W 10W NNP cord-005453-4057qib7 3404 21 / / SYM cord-005453-4057qib7 3404 22 min min NN cord-005453-4057qib7 3404 23 incremental incremental JJ cord-005453-4057qib7 3404 24 phase phase NN cord-005453-4057qib7 3404 25 , , , cord-005453-4057qib7 3404 26 up up IN cord-005453-4057qib7 3404 27 to to IN cord-005453-4057qib7 3404 28 exhaustion exhaustion NN cord-005453-4057qib7 3404 29 , , , cord-005453-4057qib7 3404 30 then then RB cord-005453-4057qib7 3404 31 a a DT cord-005453-4057qib7 3404 32 2-min 2-min JJ cord-005453-4057qib7 3404 33 active active JJ cord-005453-4057qib7 3404 34 recovery recovery NN cord-005453-4057qib7 3404 35 of of IN cord-005453-4057qib7 3404 36 20W 20w NN cord-005453-4057qib7 3404 37 pedaling pedaling NN cord-005453-4057qib7 3404 38 , , , cord-005453-4057qib7 3404 39 then then RB cord-005453-4057qib7 3404 40 a a DT cord-005453-4057qib7 3404 41 2-min 2-min JJ cord-005453-4057qib7 3404 42 passive passive JJ cord-005453-4057qib7 3404 43 recovery recovery NN cord-005453-4057qib7 3404 44 . . . cord-005453-4057qib7 3405 1 Three three CD cord-005453-4057qib7 3405 2 exercise exercise NN cord-005453-4057qib7 3405 3 markers marker NNS cord-005453-4057qib7 3405 4 were be VBD cord-005453-4057qib7 3405 5 analysed analyse VBN cord-005453-4057qib7 3405 6 : : : cord-005453-4057qib7 3405 7 the the DT cord-005453-4057qib7 3405 8 peak peak NN cord-005453-4057qib7 3405 9 of of IN cord-005453-4057qib7 3405 10 oxygen oxygen NN cord-005453-4057qib7 3405 11 uptake uptake NN cord-005453-4057qib7 3405 12 ( ( -LRB- cord-005453-4057qib7 3405 13 peak peak NNP cord-005453-4057qib7 3405 14 VO VO NNP cord-005453-4057qib7 3405 15 2 2 CD cord-005453-4057qib7 3405 16 ) ) -RRB- cord-005453-4057qib7 3405 17 , , , cord-005453-4057qib7 3405 18 the the DT cord-005453-4057qib7 3405 19 VE VE NNP cord-005453-4057qib7 3405 20 / / SYM cord-005453-4057qib7 3405 21 VCO VCO NNP cord-005453-4057qib7 3405 22 2 2 CD cord-005453-4057qib7 3405 23 slope slope NN cord-005453-4057qib7 3405 24 and and CC cord-005453-4057qib7 3405 25 the the DT cord-005453-4057qib7 3405 26 first first JJ cord-005453-4057qib7 3405 27 ventilatory ventilatory JJ cord-005453-4057qib7 3405 28 threshold threshold NN cord-005453-4057qib7 3405 29 ( ( -LRB- cord-005453-4057qib7 3405 30 VT VT NNP cord-005453-4057qib7 3405 31 1 1 CD cord-005453-4057qib7 3405 32 ) ) -RRB- cord-005453-4057qib7 3405 33 . . . cord-005453-4057qib7 3406 1 Data datum NNS cord-005453-4057qib7 3406 2 relative relative JJ cord-005453-4057qib7 3406 3 to to IN cord-005453-4057qib7 3406 4 conditioning conditioning NN cord-005453-4057qib7 3406 5 regimen regimen NN cord-005453-4057qib7 3406 6 , , , cord-005453-4057qib7 3406 7 short short JJ cord-005453-4057qib7 3406 8 - - HYPH cord-005453-4057qib7 3406 9 term term NN cord-005453-4057qib7 3406 10 complications complication NNS cord-005453-4057qib7 3406 11 , , , cord-005453-4057qib7 3406 12 impairment impairment NN cord-005453-4057qib7 3406 13 at at IN cord-005453-4057qib7 3406 14 CPET CPET NNP cord-005453-4057qib7 3406 15 day day NN cord-005453-4057qib7 3406 16 , , , cord-005453-4057qib7 3406 17 and and CC cord-005453-4057qib7 3406 18 physical physical JJ cord-005453-4057qib7 3406 19 activity activity NN cord-005453-4057qib7 3406 20 since since IN cord-005453-4057qib7 3406 21 allo allo NN cord-005453-4057qib7 3406 22 - - HYPH cord-005453-4057qib7 3406 23 HSCT HSCT NNP cord-005453-4057qib7 3406 24 were be VBD cord-005453-4057qib7 3406 25 gathered gather VBN cord-005453-4057qib7 3406 26 . . . cord-005453-4057qib7 3407 1 Results result NNS cord-005453-4057qib7 3407 2 : : : cord-005453-4057qib7 3408 1 After after IN cord-005453-4057qib7 3408 2 allo allo NN cord-005453-4057qib7 3408 3 - - HYPH cord-005453-4057qib7 3408 4 HSCT HSCT NNP cord-005453-4057qib7 3408 5 , , , cord-005453-4057qib7 3408 6 nearly nearly RB cord-005453-4057qib7 3408 7 3 3 CD cord-005453-4057qib7 3408 8 over over IN cord-005453-4057qib7 3408 9 4 4 CD cord-005453-4057qib7 3408 10 patients patient NNS cord-005453-4057qib7 3408 11 reported report VBD cord-005453-4057qib7 3408 12 fatigue fatigue NN cord-005453-4057qib7 3408 13 , , , cord-005453-4057qib7 3408 14 a a DT cord-005453-4057qib7 3408 15 half half NN cord-005453-4057qib7 3408 16 reported report VBN cord-005453-4057qib7 3408 17 dyspnea dyspnea NN cord-005453-4057qib7 3408 18 , , , cord-005453-4057qib7 3408 19 and and CC cord-005453-4057qib7 3408 20 1 1 CD cord-005453-4057qib7 3408 21 over over IN cord-005453-4057qib7 3408 22 4 4 CD cord-005453-4057qib7 3408 23 or or CC cord-005453-4057qib7 3408 24 more more RBR cord-005453-4057qib7 3408 25 reported report VBN cord-005453-4057qib7 3408 26 pain pain NN cord-005453-4057qib7 3408 27 , , , cord-005453-4057qib7 3408 28 muscular muscular JJ cord-005453-4057qib7 3408 29 , , , cord-005453-4057qib7 3408 30 neurological neurological JJ cord-005453-4057qib7 3408 31 or or CC cord-005453-4057qib7 3408 32 psychological psychological JJ cord-005453-4057qib7 3408 33 impairment impairment NN cord-005453-4057qib7 3408 34 . . . cord-005453-4057qib7 3409 1 More More JJR cord-005453-4057qib7 3409 2 than than IN cord-005453-4057qib7 3409 3 60 60 CD cord-005453-4057qib7 3409 4 % % NN cord-005453-4057qib7 3409 5 of of IN cord-005453-4057qib7 3409 6 patients patient NNS cord-005453-4057qib7 3409 7 suffer suffer VBP cord-005453-4057qib7 3409 8 from from IN cord-005453-4057qib7 3409 9 moderate moderate JJ cord-005453-4057qib7 3409 10 or or CC cord-005453-4057qib7 3409 11 severe severe JJ cord-005453-4057qib7 3409 12 physical physical JJ cord-005453-4057qib7 3409 13 intolerance intolerance NN cord-005453-4057qib7 3409 14 , , , cord-005453-4057qib7 3409 15 particularly particularly RB cord-005453-4057qib7 3409 16 when when WRB cord-005453-4057qib7 3409 17 myeloablative myeloablative NNP cord-005453-4057qib7 3409 18 conditioning conditioning NNP cord-005453-4057qib7 3409 19 regimen regimen NN cord-005453-4057qib7 3409 20 was be VBD cord-005453-4057qib7 3409 21 used use VBN cord-005453-4057qib7 3409 22 . . . cord-005453-4057qib7 3410 1 Only only RB cord-005453-4057qib7 3410 2 37 37 CD cord-005453-4057qib7 3410 3 % % NN cord-005453-4057qib7 3410 4 of of IN cord-005453-4057qib7 3410 5 patients patient NNS cord-005453-4057qib7 3410 6 followed follow VBD cord-005453-4057qib7 3410 7 rehabilitation rehabilitation NN cord-005453-4057qib7 3410 8 sessions session NNS cord-005453-4057qib7 3410 9 supervised supervise VBN cord-005453-4057qib7 3410 10 by by IN cord-005453-4057qib7 3410 11 a a DT cord-005453-4057qib7 3410 12 physiotherapist physiotherapist NN cord-005453-4057qib7 3410 13 , , , cord-005453-4057qib7 3410 14 and and CC cord-005453-4057qib7 3410 15 non non JJ cord-005453-4057qib7 3410 16 - - JJ cord-005453-4057qib7 3410 17 supervised supervised JJ cord-005453-4057qib7 3410 18 physical physical JJ cord-005453-4057qib7 3410 19 activity activity NN cord-005453-4057qib7 3410 20 has have VBZ cord-005453-4057qib7 3410 21 been be VBN cord-005453-4057qib7 3410 22 performed perform VBN cord-005453-4057qib7 3410 23 by by IN cord-005453-4057qib7 3410 24 87 87 CD cord-005453-4057qib7 3410 25 % % NN cord-005453-4057qib7 3410 26 of of IN cord-005453-4057qib7 3410 27 patients patient NNS cord-005453-4057qib7 3410 28 . . . cord-005453-4057qib7 3411 1 Despite despite IN cord-005453-4057qib7 3411 2 normal normal JJ cord-005453-4057qib7 3411 3 lung lung NN cord-005453-4057qib7 3411 4 function function NN cord-005453-4057qib7 3411 5 tests test NNS cord-005453-4057qib7 3411 6 and and CC cord-005453-4057qib7 3411 7 echocardiography echocardiography NN cord-005453-4057qib7 3411 8 findings finding NNS cord-005453-4057qib7 3411 9 in in IN cord-005453-4057qib7 3411 10 most most JJS cord-005453-4057qib7 3411 11 patients patient NNS cord-005453-4057qib7 3411 12 , , , cord-005453-4057qib7 3411 13 80 80 CD cord-005453-4057qib7 3411 14 % % NN cord-005453-4057qib7 3411 15 had have VBD cord-005453-4057qib7 3411 16 exercise exercise NN cord-005453-4057qib7 3411 17 intolerance intolerance NN cord-005453-4057qib7 3411 18 ( ( -LRB- cord-005453-4057qib7 3411 19 EI EI NNP cord-005453-4057qib7 3411 20 ) ) -RRB- cord-005453-4057qib7 3411 21 , , , cord-005453-4057qib7 3411 22 85 85 CD cord-005453-4057qib7 3411 23 % % NN cord-005453-4057qib7 3411 24 exercise exercise NN cord-005453-4057qib7 3411 25 deconditioning deconditioning NN cord-005453-4057qib7 3411 26 , , , cord-005453-4057qib7 3411 27 and and CC cord-005453-4057qib7 3411 28 55 55 CD cord-005453-4057qib7 3411 29 % % NN cord-005453-4057qib7 3411 30 had have VBD cord-005453-4057qib7 3411 31 abnormal abnormal JJ cord-005453-4057qib7 3411 32 ventilatory ventilatory JJ cord-005453-4057qib7 3411 33 efficiency efficiency NN cord-005453-4057qib7 3411 34 . . . cord-005453-4057qib7 3412 1 Patients patient NNS cord-005453-4057qib7 3412 2 with with IN cord-005453-4057qib7 3412 3 moderate moderate JJ cord-005453-4057qib7 3412 4 and and CC cord-005453-4057qib7 3412 5 severe severe JJ cord-005453-4057qib7 3412 6 impaired impaired JJ cord-005453-4057qib7 3412 7 exercise exercise NN cord-005453-4057qib7 3412 8 capacity capacity NN cord-005453-4057qib7 3412 9 were be VBD cord-005453-4057qib7 3412 10 significantly significantly RB cord-005453-4057qib7 3412 11 younger young JJR cord-005453-4057qib7 3412 12 at at IN cord-005453-4057qib7 3412 13 diagnosis diagnosis NN cord-005453-4057qib7 3412 14 and and CC cord-005453-4057qib7 3412 15 at at IN cord-005453-4057qib7 3412 16 allo allo NN cord-005453-4057qib7 3412 17 - - HYPH cord-005453-4057qib7 3412 18 HSCT HSCT NNP cord-005453-4057qib7 3412 19 , , , cord-005453-4057qib7 3412 20 such such JJ cord-005453-4057qib7 3412 21 as as IN cord-005453-4057qib7 3412 22 patients patient NNS cord-005453-4057qib7 3412 23 with with IN cord-005453-4057qib7 3412 24 severe severe JJ cord-005453-4057qib7 3412 25 deconditioning deconditione VBG cord-005453-4057qib7 3412 26 Conclusions conclusion NNS cord-005453-4057qib7 3412 27 : : : cord-005453-4057qib7 3413 1 Based base VBN cord-005453-4057qib7 3413 2 on on IN cord-005453-4057qib7 3413 3 a a DT cord-005453-4057qib7 3413 4 retrospective retrospective JJ cord-005453-4057qib7 3413 5 study study NN cord-005453-4057qib7 3413 6 , , , cord-005453-4057qib7 3413 7 we -PRON- PRP cord-005453-4057qib7 3413 8 reported report VBD cord-005453-4057qib7 3413 9 for for IN cord-005453-4057qib7 3413 10 the the DT cord-005453-4057qib7 3413 11 first first JJ cord-005453-4057qib7 3413 12 time time NN cord-005453-4057qib7 3413 13 complete complete JJ cord-005453-4057qib7 3413 14 results result NNS cord-005453-4057qib7 3413 15 from from IN cord-005453-4057qib7 3413 16 CPET CPET NNS cord-005453-4057qib7 3413 17 and and CC cord-005453-4057qib7 3413 18 detailed detailed JJ cord-005453-4057qib7 3413 19 clinical clinical JJ cord-005453-4057qib7 3413 20 evaluation evaluation NN cord-005453-4057qib7 3413 21 concerning concern VBG cord-005453-4057qib7 3413 22 deficiency deficiency NN cord-005453-4057qib7 3413 23 and and CC cord-005453-4057qib7 3413 24 disability disability NN cord-005453-4057qib7 3413 25 following follow VBG cord-005453-4057qib7 3413 26 first first JJ cord-005453-4057qib7 3413 27 year year NN cord-005453-4057qib7 3413 28 after after IN cord-005453-4057qib7 3413 29 allo allo NN cord-005453-4057qib7 3413 30 - - HYPH cord-005453-4057qib7 3413 31 HSCT HSCT NNP cord-005453-4057qib7 3413 32 . . . cord-005453-4057qib7 3414 1 These these DT cord-005453-4057qib7 3414 2 results result NNS cord-005453-4057qib7 3414 3 confirm confirm VBP cord-005453-4057qib7 3414 4 that that IN cord-005453-4057qib7 3414 5 exercise exercise NN cord-005453-4057qib7 3414 6 impairment impairment NN cord-005453-4057qib7 3414 7 is be VBZ cord-005453-4057qib7 3414 8 very very RB cord-005453-4057qib7 3414 9 frequent frequent JJ cord-005453-4057qib7 3414 10 with with IN cord-005453-4057qib7 3414 11 more more JJR cord-005453-4057qib7 3414 12 than than IN cord-005453-4057qib7 3414 13 a a DT cord-005453-4057qib7 3414 14 half half NN cord-005453-4057qib7 3414 15 of of IN cord-005453-4057qib7 3414 16 patients patient NNS cord-005453-4057qib7 3414 17 suffering suffer VBG cord-005453-4057qib7 3414 18 from from IN cord-005453-4057qib7 3414 19 alterations alteration NNS cord-005453-4057qib7 3414 20 of of IN cord-005453-4057qib7 3414 21 one one CD cord-005453-4057qib7 3414 22 or or CC cord-005453-4057qib7 3414 23 more more JJR cord-005453-4057qib7 3414 24 of of IN cord-005453-4057qib7 3414 25 the the DT cord-005453-4057qib7 3414 26 three three CD cord-005453-4057qib7 3414 27 performance performance NN cord-005453-4057qib7 3414 28 markers marker NNS cord-005453-4057qib7 3414 29 , , , cord-005453-4057qib7 3414 30 despite despite IN cord-005453-4057qib7 3414 31 being be VBG cord-005453-4057qib7 3414 32 active active JJ cord-005453-4057qib7 3414 33 . . . cord-005453-4057qib7 3415 1 Disclosure disclosure NN cord-005453-4057qib7 3415 2 : : : cord-005453-4057qib7 3415 3 Nothing nothing NN cord-005453-4057qib7 3415 4 to to TO cord-005453-4057qib7 3415 5 declare declare VB cord-005453-4057qib7 3415 6 Demyelinating demyelinating NN cord-005453-4057qib7 3415 7 disorders disorder NNS cord-005453-4057qib7 3415 8 : : : cord-005453-4057qib7 3416 1 A a DT cord-005453-4057qib7 3416 2 paradigm paradigm NN cord-005453-4057qib7 3416 3 of of IN cord-005453-4057qib7 3416 4 immunity immunity NN cord-005453-4057qib7 3416 5 disorders disorder NNS cord-005453-4057qib7 3416 6 after after IN cord-005453-4057qib7 3416 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 3416 8 stem stem NN cord-005453-4057qib7 3416 9 cell cell NN cord-005453-4057qib7 3416 10 transplantation transplantation NN cord-005453-4057qib7 3416 11 Background background NN cord-005453-4057qib7 3416 12 : : : cord-005453-4057qib7 3417 1 Neurologic neurologic JJ cord-005453-4057qib7 3417 2 complications complication NNS cord-005453-4057qib7 3417 3 are be VBP cord-005453-4057qib7 3417 4 a a DT cord-005453-4057qib7 3417 5 major major JJ cord-005453-4057qib7 3417 6 problem problem NN cord-005453-4057qib7 3417 7 in in IN cord-005453-4057qib7 3417 8 patients patient NNS cord-005453-4057qib7 3417 9 who who WP cord-005453-4057qib7 3417 10 undergone undergo VBD cord-005453-4057qib7 3417 11 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 3417 12 Stem Stem NNP cord-005453-4057qib7 3417 13 Cell cell NN cord-005453-4057qib7 3417 14 Transplantation transplantation NN cord-005453-4057qib7 3417 15 ( ( -LRB- cord-005453-4057qib7 3417 16 HSCT HSCT NNP cord-005453-4057qib7 3417 17 ) ) -RRB- cord-005453-4057qib7 3417 18 . . . cord-005453-4057qib7 3418 1 Given give VBN cord-005453-4057qib7 3418 2 the the DT cord-005453-4057qib7 3418 3 higher high JJR cord-005453-4057qib7 3418 4 survival survival NN cord-005453-4057qib7 3418 5 of of IN cord-005453-4057qib7 3418 6 transplanted transplanted JJ cord-005453-4057qib7 3418 7 patients patient NNS cord-005453-4057qib7 3418 8 , , , cord-005453-4057qib7 3418 9 the the DT cord-005453-4057qib7 3418 10 burden burden NN cord-005453-4057qib7 3418 11 of of IN cord-005453-4057qib7 3418 12 neurological neurological JJ cord-005453-4057qib7 3418 13 complications complication NNS cord-005453-4057qib7 3418 14 is be VBZ cord-005453-4057qib7 3418 15 increasing increase VBG cord-005453-4057qib7 3418 16 in in IN cord-005453-4057qib7 3418 17 the the DT cord-005453-4057qib7 3418 18 last last JJ cord-005453-4057qib7 3418 19 years year NNS cord-005453-4057qib7 3418 20 . . . cord-005453-4057qib7 3419 1 A a DT cord-005453-4057qib7 3419 2 significant significant JJ cord-005453-4057qib7 3419 3 reduction reduction NN cord-005453-4057qib7 3419 4 in in IN cord-005453-4057qib7 3419 5 overall overall JJ cord-005453-4057qib7 3419 6 survival survival NN cord-005453-4057qib7 3419 7 was be VBD cord-005453-4057qib7 3419 8 demonstrated demonstrate VBN cord-005453-4057qib7 3419 9 in in IN cord-005453-4057qib7 3419 10 patients patient NNS cord-005453-4057qib7 3419 11 who who WP cord-005453-4057qib7 3419 12 developed develop VBD cord-005453-4057qib7 3419 13 neurological neurological JJ cord-005453-4057qib7 3419 14 complication complication NN cord-005453-4057qib7 3419 15 after after IN cord-005453-4057qib7 3419 16 HSCT HSCT NNP cord-005453-4057qib7 3419 17 , , , cord-005453-4057qib7 3419 18 irrespectively irrespectively RB cord-005453-4057qib7 3419 19 of of IN cord-005453-4057qib7 3419 20 the the DT cord-005453-4057qib7 3419 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 3419 22 stem stem NN cord-005453-4057qib7 3419 23 cell cell NN cord-005453-4057qib7 3419 24 ( ( -LRB- cord-005453-4057qib7 3419 25 HSC HSC NNP cord-005453-4057qib7 3419 26 ) ) -RRB- cord-005453-4057qib7 3419 27 source source NN cord-005453-4057qib7 3419 28 . . . cord-005453-4057qib7 3420 1 Neurologic neurologic JJ cord-005453-4057qib7 3420 2 disorders disorder NNS cord-005453-4057qib7 3420 3 in in IN cord-005453-4057qib7 3420 4 transplanting transplant VBG cord-005453-4057qib7 3420 5 setting set VBG cord-005453-4057qib7 3420 6 comprise comprise VBP cord-005453-4057qib7 3420 7 a a DT cord-005453-4057qib7 3420 8 wide wide JJ cord-005453-4057qib7 3420 9 variety variety NN cord-005453-4057qib7 3420 10 of of IN cord-005453-4057qib7 3420 11 ethiologies ethiologie NNS cord-005453-4057qib7 3420 12 including include VBG cord-005453-4057qib7 3420 13 demyelinating demyelinate VBG cord-005453-4057qib7 3420 14 disease disease NN cord-005453-4057qib7 3420 15 , , , cord-005453-4057qib7 3420 16 which which WDT cord-005453-4057qib7 3420 17 are be VBP cord-005453-4057qib7 3420 18 caused cause VBN cord-005453-4057qib7 3420 19 by by IN cord-005453-4057qib7 3420 20 immune immune JJ cord-005453-4057qib7 3420 21 and and CC cord-005453-4057qib7 3420 22 non non JJ cord-005453-4057qib7 3420 23 - - JJ cord-005453-4057qib7 3420 24 immune immune JJ cord-005453-4057qib7 3420 25 mechanisms mechanism NNS cord-005453-4057qib7 3420 26 . . . cord-005453-4057qib7 3421 1 Here here RB cord-005453-4057qib7 3421 2 , , , cord-005453-4057qib7 3421 3 we -PRON- PRP cord-005453-4057qib7 3421 4 analyzed analyze VBD cord-005453-4057qib7 3421 5 the the DT cord-005453-4057qib7 3421 6 clinical clinical JJ cord-005453-4057qib7 3421 7 presentation presentation NN cord-005453-4057qib7 3421 8 and and CC cord-005453-4057qib7 3421 9 the the DT cord-005453-4057qib7 3421 10 underlie underlie JJ cord-005453-4057qib7 3421 11 ethiologies ethiologie NNS cord-005453-4057qib7 3421 12 of of IN cord-005453-4057qib7 3421 13 patients patient NNS cord-005453-4057qib7 3421 14 developing develop VBG cord-005453-4057qib7 3421 15 HSCT HSCT NNP cord-005453-4057qib7 3421 16 - - HYPH cord-005453-4057qib7 3421 17 related relate VBN cord-005453-4057qib7 3421 18 demyelinating demyelinating JJ cord-005453-4057qib7 3421 19 disorders disorder NNS cord-005453-4057qib7 3421 20 in in IN cord-005453-4057qib7 3421 21 order order NN cord-005453-4057qib7 3421 22 to to TO cord-005453-4057qib7 3421 23 give give VB cord-005453-4057qib7 3421 24 diagnostic diagnostic JJ cord-005453-4057qib7 3421 25 and and CC cord-005453-4057qib7 3421 26 prognostic prognostic JJ cord-005453-4057qib7 3421 27 clues clue NNS cord-005453-4057qib7 3421 28 useful useful JJ cord-005453-4057qib7 3421 29 to to TO cord-005453-4057qib7 3421 30 manage manage VB cord-005453-4057qib7 3421 31 these these DT cord-005453-4057qib7 3421 32 severe severe JJ cord-005453-4057qib7 3421 33 but but CC cord-005453-4057qib7 3421 34 treatable treatable JJ cord-005453-4057qib7 3421 35 complications complication NNS cord-005453-4057qib7 3421 36 in in IN cord-005453-4057qib7 3421 37 the the DT cord-005453-4057qib7 3421 38 transplant transplant NN cord-005453-4057qib7 3421 39 setting setting NN cord-005453-4057qib7 3421 40 . . . cord-005453-4057qib7 3422 1 Methods method NNS cord-005453-4057qib7 3422 2 : : : cord-005453-4057qib7 3422 3 A a DT cord-005453-4057qib7 3422 4 total total NN cord-005453-4057qib7 3422 5 of of IN cord-005453-4057qib7 3422 6 45 45 CD cord-005453-4057qib7 3422 7 patients patient NNS cord-005453-4057qib7 3422 8 of of IN cord-005453-4057qib7 3422 9 our -PRON- PRP$ cord-005453-4057qib7 3422 10 department department NN cord-005453-4057qib7 3422 11 which which WDT cord-005453-4057qib7 3422 12 developed develop VBD cord-005453-4057qib7 3422 13 neurological neurological JJ cord-005453-4057qib7 3422 14 complications complication NNS cord-005453-4057qib7 3422 15 after after IN cord-005453-4057qib7 3422 16 HSCT HSCT NNP cord-005453-4057qib7 3422 17 were be VBD cord-005453-4057qib7 3422 18 consecutively consecutively RB cord-005453-4057qib7 3422 19 collected collect VBN cord-005453-4057qib7 3422 20 and and CC cord-005453-4057qib7 3422 21 33 33 CD cord-005453-4057qib7 3422 22 ( ( -LRB- cord-005453-4057qib7 3422 23 73 73 CD cord-005453-4057qib7 3422 24 % % NN cord-005453-4057qib7 3422 25 ) ) -RRB- cord-005453-4057qib7 3422 26 of of IN cord-005453-4057qib7 3422 27 them -PRON- PRP cord-005453-4057qib7 3422 28 , , , cord-005453-4057qib7 3422 29 namely namely RB cord-005453-4057qib7 3422 30 those those DT cord-005453-4057qib7 3422 31 having have VBG cord-005453-4057qib7 3422 32 a a DT cord-005453-4057qib7 3422 33 diagnosis diagnosis NN cord-005453-4057qib7 3422 34 of of IN cord-005453-4057qib7 3422 35 a a DT cord-005453-4057qib7 3422 36 demyelinating demyelinating JJ cord-005453-4057qib7 3422 37 disorder disorder NN cord-005453-4057qib7 3422 38 , , , cord-005453-4057qib7 3422 39 were be VBD cord-005453-4057qib7 3422 40 grouped group VBN cord-005453-4057qib7 3422 41 and and CC cord-005453-4057qib7 3422 42 described describe VBN cord-005453-4057qib7 3422 43 according accord VBG cord-005453-4057qib7 3422 44 to to IN cord-005453-4057qib7 3422 45 the the DT cord-005453-4057qib7 3422 46 ethiologies ethiologie NNS cord-005453-4057qib7 3422 47 of of IN cord-005453-4057qib7 3422 48 their -PRON- PRP$ cord-005453-4057qib7 3422 49 neurological neurological JJ cord-005453-4057qib7 3422 50 disorder disorder NN cord-005453-4057qib7 3422 51 . . . cord-005453-4057qib7 3423 1 Results result NNS cord-005453-4057qib7 3423 2 : : : cord-005453-4057qib7 3424 1 In in IN cord-005453-4057qib7 3424 2 14/33 14/33 CD cord-005453-4057qib7 3424 3 ( ( -LRB- cord-005453-4057qib7 3424 4 42 42 CD cord-005453-4057qib7 3424 5 % % NN cord-005453-4057qib7 3424 6 ) ) -RRB- cord-005453-4057qib7 3424 7 patients patient NNS cord-005453-4057qib7 3424 8 , , , cord-005453-4057qib7 3424 9 an an DT cord-005453-4057qib7 3424 10 immune immune NN cord-005453-4057qib7 3424 11 - - HYPH cord-005453-4057qib7 3424 12 mediated mediate VBN cord-005453-4057qib7 3424 13 process process NN cord-005453-4057qib7 3424 14 was be VBD cord-005453-4057qib7 3424 15 found find VBN cord-005453-4057qib7 3424 16 , , , cord-005453-4057qib7 3424 17 while while IN cord-005453-4057qib7 3424 18 10/33 10/33 CD cord-005453-4057qib7 3424 19 ( ( -LRB- cord-005453-4057qib7 3424 20 30 30 CD cord-005453-4057qib7 3424 21 % % NN cord-005453-4057qib7 3424 22 ) ) -RRB- cord-005453-4057qib7 3424 23 were be VBD cord-005453-4057qib7 3424 24 diagnosed diagnose VBN cord-005453-4057qib7 3424 25 as as IN cord-005453-4057qib7 3424 26 having have VBG cord-005453-4057qib7 3424 27 an an DT cord-005453-4057qib7 3424 28 infective infective JJ cord-005453-4057qib7 3424 29 etiology etiology NN cord-005453-4057qib7 3424 30 and and CC cord-005453-4057qib7 3424 31 2/33 2/33 CD cord-005453-4057qib7 3424 32 ( ( -LRB- cord-005453-4057qib7 3424 33 6 6 CD cord-005453-4057qib7 3424 34 % % NN cord-005453-4057qib7 3424 35 ) ) -RRB- cord-005453-4057qib7 3424 36 were be VBD cord-005453-4057qib7 3424 37 supposed suppose VBN cord-005453-4057qib7 3424 38 to to TO cord-005453-4057qib7 3424 39 have have VB cord-005453-4057qib7 3424 40 a a DT cord-005453-4057qib7 3424 41 demyelinating demyelinating JJ cord-005453-4057qib7 3424 42 disorder disorder NN cord-005453-4057qib7 3424 43 caused cause VBN cord-005453-4057qib7 3424 44 by by IN cord-005453-4057qib7 3424 45 toxic toxic JJ cord-005453-4057qib7 3424 46 exposition exposition NN cord-005453-4057qib7 3424 47 . . . cord-005453-4057qib7 3425 1 A a DT cord-005453-4057qib7 3425 2 definitive definitive JJ cord-005453-4057qib7 3425 3 etiologic etiologic JJ cord-005453-4057qib7 3425 4 diagnosis diagnosis NN cord-005453-4057qib7 3425 5 was be VBD cord-005453-4057qib7 3425 6 not not RB cord-005453-4057qib7 3425 7 formulated formulate VBN cord-005453-4057qib7 3425 8 in in IN cord-005453-4057qib7 3425 9 the the DT cord-005453-4057qib7 3425 10 remaining remain VBG cord-005453-4057qib7 3425 11 7/33 7/33 CD cord-005453-4057qib7 3425 12 ( ( -LRB- cord-005453-4057qib7 3425 13 21 21 CD cord-005453-4057qib7 3425 14 % % NN cord-005453-4057qib7 3425 15 ) ) -RRB- cord-005453-4057qib7 3425 16 patients patient NNS cord-005453-4057qib7 3425 17 . . . cord-005453-4057qib7 3426 1 When when WRB cord-005453-4057qib7 3426 2 patients patient NNS cord-005453-4057qib7 3426 3 who who WP cord-005453-4057qib7 3426 4 developed develop VBD cord-005453-4057qib7 3426 5 an an DT cord-005453-4057qib7 3426 6 immune immune NN cord-005453-4057qib7 3426 7 - - HYPH cord-005453-4057qib7 3426 8 mediated mediate VBN cord-005453-4057qib7 3426 9 demyelinating demyelinating NN cord-005453-4057qib7 3426 10 disorder disorder NN cord-005453-4057qib7 3426 11 ( ( -LRB- cord-005453-4057qib7 3426 12 10/33 10/33 CD cord-005453-4057qib7 3426 13 ) ) -RRB- cord-005453-4057qib7 3426 14 were be VBD cord-005453-4057qib7 3426 15 compared compare VBN cord-005453-4057qib7 3426 16 to to IN cord-005453-4057qib7 3426 17 those those DT cord-005453-4057qib7 3426 18 in in IN cord-005453-4057qib7 3426 19 which which WDT cord-005453-4057qib7 3426 20 a a DT cord-005453-4057qib7 3426 21 clear clear JJ cord-005453-4057qib7 3426 22 immune immune JJ cord-005453-4057qib7 3426 23 pathogenic pathogenic JJ cord-005453-4057qib7 3426 24 mechanism mechanism NN cord-005453-4057qib7 3426 25 was be VBD cord-005453-4057qib7 3426 26 not not RB cord-005453-4057qib7 3426 27 detected detect VBN cord-005453-4057qib7 3426 28 ( ( -LRB- cord-005453-4057qib7 3426 29 23/33 23/33 CD cord-005453-4057qib7 3426 30 ) ) -RRB- cord-005453-4057qib7 3426 31 , , , cord-005453-4057qib7 3426 32 a a DT cord-005453-4057qib7 3426 33 higher high JJR cord-005453-4057qib7 3426 34 incidence incidence NN cord-005453-4057qib7 3426 35 of of IN cord-005453-4057qib7 3426 36 acute acute JJ cord-005453-4057qib7 3426 37 graft graft NN cord-005453-4057qib7 3426 38 - - HYPH cord-005453-4057qib7 3426 39 versus versus IN cord-005453-4057qib7 3426 40 - - HYPH cord-005453-4057qib7 3426 41 host host NN cord-005453-4057qib7 3426 42 disease disease NN cord-005453-4057qib7 3426 43 ( ( -LRB- cord-005453-4057qib7 3426 44 aGVHD aGVHD NNP cord-005453-4057qib7 3426 45 ) ) -RRB- cord-005453-4057qib7 3426 46 was be VBD cord-005453-4057qib7 3426 47 detected detect VBN cord-005453-4057qib7 3426 48 in in IN cord-005453-4057qib7 3426 49 the the DT cord-005453-4057qib7 3426 50 former former JJ cord-005453-4057qib7 3426 51 than than IN cord-005453-4057qib7 3426 52 in in IN cord-005453-4057qib7 3426 53 the the DT cord-005453-4057qib7 3426 54 latter latter JJ cord-005453-4057qib7 3426 55 ( ( -LRB- cord-005453-4057qib7 3426 56 20 20 CD cord-005453-4057qib7 3426 57 % % NN cord-005453-4057qib7 3426 58 vs vs IN cord-005453-4057qib7 3426 59 8 8 CD cord-005453-4057qib7 3426 60 % % NN cord-005453-4057qib7 3426 61 ) ) -RRB- cord-005453-4057qib7 3426 62 . . . cord-005453-4057qib7 3427 1 Moreover moreover RB cord-005453-4057qib7 3427 2 , , , cord-005453-4057qib7 3427 3 comparison comparison NN cord-005453-4057qib7 3427 4 of of IN cord-005453-4057qib7 3427 5 these these DT cord-005453-4057qib7 3427 6 two two CD cord-005453-4057qib7 3427 7 groups group NNS cord-005453-4057qib7 3427 8 revealed reveal VBD cord-005453-4057qib7 3427 9 that that IN cord-005453-4057qib7 3427 10 those those DT cord-005453-4057qib7 3427 11 with with IN cord-005453-4057qib7 3427 12 no no DT cord-005453-4057qib7 3427 13 evidence evidence NN cord-005453-4057qib7 3427 14 of of IN cord-005453-4057qib7 3427 15 immune immune NN cord-005453-4057qib7 3427 16 - - HYPH cord-005453-4057qib7 3427 17 mediated mediate VBN cord-005453-4057qib7 3427 18 process process NN cord-005453-4057qib7 3427 19 have have VBP cord-005453-4057qib7 3427 20 a a DT cord-005453-4057qib7 3427 21 slight slight JJ cord-005453-4057qib7 3427 22 higher high JJR cord-005453-4057qib7 3427 23 prevalence prevalence NN cord-005453-4057qib7 3427 24 of of IN cord-005453-4057qib7 3427 25 T t NN cord-005453-4057qib7 3427 26 - - HYPH cord-005453-4057qib7 3427 27 cell cell NN cord-005453-4057qib7 3427 28 depleted deplete VBN cord-005453-4057qib7 3427 29 HSCT HSCT NNP cord-005453-4057qib7 3427 30 thanthose thanthose NN cord-005453-4057qib7 3427 31 with with IN cord-005453-4057qib7 3427 32 an an DT cord-005453-4057qib7 3427 33 immune immune NN cord-005453-4057qib7 3427 34 - - HYPH cord-005453-4057qib7 3427 35 mediated mediate VBN cord-005453-4057qib7 3427 36 demyelinating demyelinating NN cord-005453-4057qib7 3427 37 disorder disorder NN cord-005453-4057qib7 3427 38 ( ( -LRB- cord-005453-4057qib7 3427 39 60 60 CD cord-005453-4057qib7 3427 40 % % NN cord-005453-4057qib7 3427 41 vs vs IN cord-005453-4057qib7 3427 42 50 50 CD cord-005453-4057qib7 3427 43 % % NN cord-005453-4057qib7 3427 44 ) ) -RRB- cord-005453-4057qib7 3427 45 . . . cord-005453-4057qib7 3428 1 Finally finally RB cord-005453-4057qib7 3428 2 , , , cord-005453-4057qib7 3428 3 a a DT cord-005453-4057qib7 3428 4 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 3428 5 disorder disorder NN cord-005453-4057qib7 3428 6 pre pre VBN cord-005453-4057qib7 3428 7 - - JJ cord-005453-4057qib7 3428 8 existing existing JJ cord-005453-4057qib7 3429 1 the the DT cord-005453-4057qib7 3429 2 HSCT HSCT NNP cord-005453-4057qib7 3429 3 was be VBD cord-005453-4057qib7 3429 4 detected detect VBN cord-005453-4057qib7 3429 5 in in IN cord-005453-4057qib7 3429 6 5/14 5/14 CD cord-005453-4057qib7 3429 7 ( ( -LRB- cord-005453-4057qib7 3429 8 36 36 CD cord-005453-4057qib7 3429 9 % % NN cord-005453-4057qib7 3429 10 ) ) -RRB- cord-005453-4057qib7 3429 11 patients patient NNS cord-005453-4057qib7 3429 12 with with IN cord-005453-4057qib7 3429 13 immune immune NN cord-005453-4057qib7 3429 14 - - HYPH cord-005453-4057qib7 3429 15 mediated mediate VBN cord-005453-4057qib7 3429 16 demyelinating demyelinating JJ cord-005453-4057qib7 3429 17 disorder disorder NN cord-005453-4057qib7 3429 18 but but CC cord-005453-4057qib7 3429 19 only only RB cord-005453-4057qib7 3429 20 in in IN cord-005453-4057qib7 3429 21 4/19 4/19 CD cord-005453-4057qib7 3429 22 ( ( -LRB- cord-005453-4057qib7 3429 23 21 21 CD cord-005453-4057qib7 3429 24 % % NN cord-005453-4057qib7 3429 25 ) ) -RRB- cord-005453-4057qib7 3429 26 of of IN cord-005453-4057qib7 3429 27 those those DT cord-005453-4057qib7 3429 28 without without IN cord-005453-4057qib7 3429 29 evidence evidence NN cord-005453-4057qib7 3429 30 of of IN cord-005453-4057qib7 3429 31 immune immune NN cord-005453-4057qib7 3429 32 - - HYPH cord-005453-4057qib7 3429 33 mediated mediate VBN cord-005453-4057qib7 3429 34 processes process NNS cord-005453-4057qib7 3429 35 . . . cord-005453-4057qib7 3430 1 Conclusions conclusion NNS cord-005453-4057qib7 3430 2 : : : cord-005453-4057qib7 3431 1 Demyelinating demyelinating NN cord-005453-4057qib7 3431 2 disorders disorder NNS cord-005453-4057qib7 3431 3 may may MD cord-005453-4057qib7 3431 4 be be VB cord-005453-4057qib7 3431 5 responsible responsible JJ cord-005453-4057qib7 3431 6 of of IN cord-005453-4057qib7 3431 7 near near IN cord-005453-4057qib7 3431 8 40 40 CD cord-005453-4057qib7 3431 9 % % NN cord-005453-4057qib7 3431 10 of of IN cord-005453-4057qib7 3431 11 neurologic neurologic JJ cord-005453-4057qib7 3431 12 complications complication NNS cord-005453-4057qib7 3431 13 in in IN cord-005453-4057qib7 3431 14 the the DT cord-005453-4057qib7 3431 15 posttransplant posttransplant NN cord-005453-4057qib7 3431 16 setting setting NN cord-005453-4057qib7 3431 17 and and CC cord-005453-4057qib7 3431 18 , , , cord-005453-4057qib7 3431 19 among among IN cord-005453-4057qib7 3431 20 them -PRON- PRP cord-005453-4057qib7 3431 21 , , , cord-005453-4057qib7 3431 22 an an DT cord-005453-4057qib7 3431 23 immune immune NN cord-005453-4057qib7 3431 24 - - HYPH cord-005453-4057qib7 3431 25 mediated mediate VBN cord-005453-4057qib7 3431 26 process process NN cord-005453-4057qib7 3431 27 is be VBZ cord-005453-4057qib7 3431 28 likely likely JJ cord-005453-4057qib7 3431 29 to to TO cord-005453-4057qib7 3431 30 be be VB cord-005453-4057qib7 3431 31 involved involve VBN cord-005453-4057qib7 3431 32 in in IN cord-005453-4057qib7 3431 33 more more JJR cord-005453-4057qib7 3431 34 than than IN cord-005453-4057qib7 3431 35 40 40 CD cord-005453-4057qib7 3431 36 % % NN cord-005453-4057qib7 3431 37 of of IN cord-005453-4057qib7 3431 38 cases case NNS cord-005453-4057qib7 3431 39 . . . cord-005453-4057qib7 3432 1 Our -PRON- PRP$ cord-005453-4057qib7 3432 2 results result NNS cord-005453-4057qib7 3432 3 suggest suggest VBP cord-005453-4057qib7 3432 4 that that IN cord-005453-4057qib7 3432 5 the the DT cord-005453-4057qib7 3432 6 immune immune JJ cord-005453-4057qib7 3432 7 mechanism mechanism NN cord-005453-4057qib7 3432 8 that that WDT cord-005453-4057qib7 3432 9 underliesthe underliesthe NNP cord-005453-4057qib7 3432 10 aGVHD aGVHD NNP cord-005453-4057qib7 3432 11 may may MD cord-005453-4057qib7 3432 12 also also RB cord-005453-4057qib7 3432 13 be be VB cord-005453-4057qib7 3432 14 involved involve VBN cord-005453-4057qib7 3432 15 in in IN cord-005453-4057qib7 3432 16 developing develop VBG cord-005453-4057qib7 3432 17 demyelinating demyelinate VBG cord-005453-4057qib7 3432 18 disease disease NN cord-005453-4057qib7 3432 19 in in IN cord-005453-4057qib7 3432 20 transplanted transplanted JJ cord-005453-4057qib7 3432 21 patients patient NNS cord-005453-4057qib7 3432 22 . . . cord-005453-4057qib7 3433 1 It -PRON- PRP cord-005453-4057qib7 3433 2 also also RB cord-005453-4057qib7 3433 3 may may MD cord-005453-4057qib7 3433 4 be be VB cord-005453-4057qib7 3433 5 possible possible JJ cord-005453-4057qib7 3433 6 that that IN cord-005453-4057qib7 3433 7 the the DT cord-005453-4057qib7 3433 8 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 3433 9 disorder disorder NN cord-005453-4057qib7 3433 10 preexisting preexist VBG cord-005453-4057qib7 3433 11 the the DT cord-005453-4057qib7 3433 12 HSCT HSCT NNP cord-005453-4057qib7 3433 13 is be VBZ cord-005453-4057qib7 3433 14 a a DT cord-005453-4057qib7 3433 15 risk risk NN cord-005453-4057qib7 3433 16 factor factor NN cord-005453-4057qib7 3433 17 able able JJ cord-005453-4057qib7 3433 18 to to TO cord-005453-4057qib7 3433 19 increase increase VB cord-005453-4057qib7 3433 20 the the DT cord-005453-4057qib7 3433 21 risk risk NN cord-005453-4057qib7 3433 22 to to TO cord-005453-4057qib7 3433 23 develop develop VB cord-005453-4057qib7 3433 24 an an DT cord-005453-4057qib7 3433 25 immune immune NN cord-005453-4057qib7 3433 26 - - HYPH cord-005453-4057qib7 3433 27 mediated mediate VBN cord-005453-4057qib7 3433 28 demyelinating demyelinating JJ cord-005453-4057qib7 3433 29 disorder disorder NN cord-005453-4057qib7 3433 30 in in IN cord-005453-4057qib7 3433 31 the the DT cord-005453-4057qib7 3433 32 post post NN cord-005453-4057qib7 3433 33 - - JJ cord-005453-4057qib7 3433 34 transplanting transplanting JJ cord-005453-4057qib7 3433 35 setting setting NN cord-005453-4057qib7 3433 36 . . . cord-005453-4057qib7 3434 1 Using use VBG cord-005453-4057qib7 3434 2 a a DT cord-005453-4057qib7 3434 3 T t NN cord-005453-4057qib7 3434 4 - - HYPH cord-005453-4057qib7 3434 5 cell cell NN cord-005453-4057qib7 3434 6 depleted deplete VBN cord-005453-4057qib7 3434 7 HSCT HSCT NNP cord-005453-4057qib7 3434 8 can can MD cord-005453-4057qib7 3434 9 increase increase VB cord-005453-4057qib7 3434 10 the the DT cord-005453-4057qib7 3434 11 risk risk NN cord-005453-4057qib7 3434 12 of of IN cord-005453-4057qib7 3434 13 immune immune NN cord-005453-4057qib7 3434 14 - - HYPH cord-005453-4057qib7 3434 15 mediated mediate VBN cord-005453-4057qib7 3434 16 disorders disorder NNS cord-005453-4057qib7 3434 17 in in IN cord-005453-4057qib7 3434 18 at at IN cord-005453-4057qib7 3434 19 least least JJS cord-005453-4057qib7 3434 20 a a DT cord-005453-4057qib7 3434 21 small small JJ cord-005453-4057qib7 3434 22 fraction fraction NN cord-005453-4057qib7 3434 23 of of IN cord-005453-4057qib7 3434 24 transplanted transplanted JJ cord-005453-4057qib7 3434 25 patients patient NNS cord-005453-4057qib7 3434 26 . . . cord-005453-4057qib7 3435 1 Despite despite IN cord-005453-4057qib7 3435 2 our -PRON- PRP$ cord-005453-4057qib7 3435 3 results result NNS cord-005453-4057qib7 3435 4 should should MD cord-005453-4057qib7 3435 5 be be VB cord-005453-4057qib7 3435 6 validated validate VBN cord-005453-4057qib7 3435 7 on on IN cord-005453-4057qib7 3435 8 a a DT cord-005453-4057qib7 3435 9 larger large JJR cord-005453-4057qib7 3435 10 cohort cohort NN cord-005453-4057qib7 3435 11 of of IN cord-005453-4057qib7 3435 12 patients patient NNS cord-005453-4057qib7 3435 13 , , , cord-005453-4057qib7 3435 14 we -PRON- PRP cord-005453-4057qib7 3435 15 can can MD cord-005453-4057qib7 3435 16 speculate speculate VB cord-005453-4057qib7 3435 17 on on IN cord-005453-4057qib7 3435 18 the the DT cord-005453-4057qib7 3435 19 possible possible JJ cord-005453-4057qib7 3435 20 connections connection NNS cord-005453-4057qib7 3435 21 between between IN cord-005453-4057qib7 3435 22 the the DT cord-005453-4057qib7 3435 23 wide wide JJ cord-005453-4057qib7 3435 24 range range NN cord-005453-4057qib7 3435 25 of of IN cord-005453-4057qib7 3435 26 complex complex NN cord-005453-4057qib7 3435 27 and and CC cord-005453-4057qib7 3435 28 still still RB cord-005453-4057qib7 3435 29 poorly poorly RB cord-005453-4057qib7 3435 30 defined define VBN cord-005453-4057qib7 3435 31 immunity immunity NN cord-005453-4057qib7 3435 32 disorders disorder NNS cord-005453-4057qib7 3435 33 which which WDT cord-005453-4057qib7 3435 34 can can MD cord-005453-4057qib7 3435 35 influence influence VB cord-005453-4057qib7 3435 36 the the DT cord-005453-4057qib7 3435 37 prognosis prognosis NN cord-005453-4057qib7 3435 38 and and CC cord-005453-4057qib7 3435 39 course course NN cord-005453-4057qib7 3435 40 of of IN cord-005453-4057qib7 3435 41 transplanted transplanted JJ cord-005453-4057qib7 3435 42 patients patient NNS cord-005453-4057qib7 3435 43 . . . cord-005453-4057qib7 3436 1 Disclosure disclosure NN cord-005453-4057qib7 3436 2 Background background NN cord-005453-4057qib7 3436 3 : : : cord-005453-4057qib7 3437 1 Injury injury NN cord-005453-4057qib7 3437 2 to to IN cord-005453-4057qib7 3437 3 the the DT cord-005453-4057qib7 3437 4 mucosal mucosal JJ cord-005453-4057qib7 3437 5 barrier barrier NN cord-005453-4057qib7 3437 6 and and CC cord-005453-4057qib7 3437 7 subsequent subsequent JJ cord-005453-4057qib7 3437 8 development development NN cord-005453-4057qib7 3437 9 of of IN cord-005453-4057qib7 3437 10 oral oral JJ cord-005453-4057qib7 3437 11 mucositis mucositis NN cord-005453-4057qib7 3437 12 ( ( -LRB- cord-005453-4057qib7 3437 13 OM OM NNP cord-005453-4057qib7 3437 14 ) ) -RRB- cord-005453-4057qib7 3437 15 is be VBZ cord-005453-4057qib7 3437 16 among among IN cord-005453-4057qib7 3437 17 the the DT cord-005453-4057qib7 3437 18 most most RBS cord-005453-4057qib7 3437 19 common common JJ cord-005453-4057qib7 3437 20 toxicities toxicity NNS cord-005453-4057qib7 3437 21 of of IN cord-005453-4057qib7 3437 22 allogeneic allogeneic NN cord-005453-4057qib7 3437 23 stem stem NN cord-005453-4057qib7 3437 24 cell cell NN cord-005453-4057qib7 3437 25 transplantation transplantation NN cord-005453-4057qib7 3437 26 ( ( -LRB- cord-005453-4057qib7 3437 27 SCT SCT NNP cord-005453-4057qib7 3437 28 ) ) -RRB- cord-005453-4057qib7 3437 29 . . . cord-005453-4057qib7 3438 1 Despite despite IN cord-005453-4057qib7 3438 2 the the DT cord-005453-4057qib7 3438 3 high high JJ cord-005453-4057qib7 3438 4 prevalence prevalence NN cord-005453-4057qib7 3438 5 of of IN cord-005453-4057qib7 3438 6 OM om NN cord-005453-4057qib7 3438 7 and and CC cord-005453-4057qib7 3438 8 its -PRON- PRP$ cord-005453-4057qib7 3438 9 debilitating debilitating JJ cord-005453-4057qib7 3438 10 nature nature NN cord-005453-4057qib7 3438 11 , , , cord-005453-4057qib7 3438 12 prospective prospective JJ cord-005453-4057qib7 3438 13 studies study NNS cord-005453-4057qib7 3438 14 evaluating evaluate VBG cord-005453-4057qib7 3438 15 determinants determinant NNS cord-005453-4057qib7 3438 16 of of IN cord-005453-4057qib7 3438 17 OM OM NNP cord-005453-4057qib7 3438 18 are be VBP cord-005453-4057qib7 3438 19 scarce scarce JJ cord-005453-4057qib7 3438 20 . . . cord-005453-4057qib7 3439 1 We -PRON- PRP cord-005453-4057qib7 3439 2 therefore therefore RB cord-005453-4057qib7 3439 3 prospectively prospectively RB cord-005453-4057qib7 3439 4 evaluated evaluate VBD cord-005453-4057qib7 3439 5 the the DT cord-005453-4057qib7 3439 6 occurrence occurrence NN cord-005453-4057qib7 3439 7 of of IN cord-005453-4057qib7 3439 8 OM OM NNP cord-005453-4057qib7 3439 9 following follow VBG cord-005453-4057qib7 3439 10 SCT SCT NNP cord-005453-4057qib7 3439 11 . . . cord-005453-4057qib7 3440 1 Risk risk NN cord-005453-4057qib7 3440 2 factors factor NNS cord-005453-4057qib7 3440 3 for for IN cord-005453-4057qib7 3440 4 OM om NN cord-005453-4057qib7 3440 5 and and CC cord-005453-4057qib7 3440 6 its -PRON- PRP$ cord-005453-4057qib7 3440 7 implications implication NNS cord-005453-4057qib7 3440 8 short short JJ cord-005453-4057qib7 3440 9 and and CC cord-005453-4057qib7 3440 10 long long JJ cord-005453-4057qib7 3440 11 - - HYPH cord-005453-4057qib7 3440 12 term term NN cord-005453-4057qib7 3440 13 outcomes outcome NNS cord-005453-4057qib7 3440 14 were be VBD cord-005453-4057qib7 3440 15 assessed assess VBN cord-005453-4057qib7 3440 16 . . . cord-005453-4057qib7 3441 1 Methods method NNS cord-005453-4057qib7 3441 2 : : : cord-005453-4057qib7 3441 3 OM OM NNP cord-005453-4057qib7 3441 4 was be VBD cord-005453-4057qib7 3441 5 prospectively prospectively RB cord-005453-4057qib7 3441 6 evaluated evaluate VBN cord-005453-4057qib7 3441 7 on on IN cord-005453-4057qib7 3441 8 a a DT cord-005453-4057qib7 3441 9 weekly weekly JJ cord-005453-4057qib7 3441 10 basis basis NN cord-005453-4057qib7 3441 11 in in IN cord-005453-4057qib7 3441 12 patients patient NNS cord-005453-4057qib7 3441 13 undergoing undergo VBG cord-005453-4057qib7 3441 14 allogeneic allogeneic IN cord-005453-4057qib7 3441 15 HSCT HSCT NNP cord-005453-4057qib7 3441 16 . . . cord-005453-4057qib7 3442 1 The the DT cord-005453-4057qib7 3442 2 grade grade NN cord-005453-4057qib7 3442 3 of of IN cord-005453-4057qib7 3442 4 OM OM NNP cord-005453-4057qib7 3442 5 was be VBD cord-005453-4057qib7 3442 6 determined determine VBN cord-005453-4057qib7 3442 7 based base VBN cord-005453-4057qib7 3442 8 on on IN cord-005453-4057qib7 3442 9 the the DT cord-005453-4057qib7 3442 10 National National NNP cord-005453-4057qib7 3442 11 Cancer Cancer NNP cord-005453-4057qib7 3442 12 Institute Institute NNP cord-005453-4057qib7 3442 13 Common Common NNP cord-005453-4057qib7 3442 14 Toxicity toxicity NN cord-005453-4057qib7 3442 15 Criteria criterion NNS cord-005453-4057qib7 3442 16 for for IN cord-005453-4057qib7 3442 17 Adverse adverse JJ cord-005453-4057qib7 3442 18 Events event NNS cord-005453-4057qib7 3442 19 ( ( -LRB- cord-005453-4057qib7 3442 20 CTCAE CTCAE NNP cord-005453-4057qib7 3442 21 ) ) -RRB- cord-005453-4057qib7 3442 22 scale scale NN cord-005453-4057qib7 3442 23 ( ( -LRB- cord-005453-4057qib7 3442 24 v. v. IN cord-005453-4057qib7 3442 25 4.0 4.0 CD cord-005453-4057qib7 3442 26 ) ) -RRB- cord-005453-4057qib7 3442 27 . . . cord-005453-4057qib7 3443 1 Severe severe JJ cord-005453-4057qib7 3443 2 OM om NN cord-005453-4057qib7 3443 3 was be VBD cord-005453-4057qib7 3443 4 defined define VBN cord-005453-4057qib7 3443 5 as as IN cord-005453-4057qib7 3443 6 grade grade NN cord-005453-4057qib7 3443 7 II II NNP cord-005453-4057qib7 3443 8 to to IN cord-005453-4057qib7 3443 9 IV IV NNP cord-005453-4057qib7 3443 10 . . . cord-005453-4057qib7 3444 1 Conditioning conditioning NN cord-005453-4057qib7 3444 2 regimens regimen NNS cord-005453-4057qib7 3444 3 were be VBD cord-005453-4057qib7 3444 4 evaluated evaluate VBN cord-005453-4057qib7 3444 5 individually individually RB cord-005453-4057qib7 3444 6 and and CC cord-005453-4057qib7 3444 7 according accord VBG cord-005453-4057qib7 3444 8 to to IN cord-005453-4057qib7 3444 9 intensity intensity NN cord-005453-4057qib7 3444 10 ; ; : cord-005453-4057qib7 3444 11 myeloablative myeloablative NNP cord-005453-4057qib7 3444 12 ( ( -LRB- cord-005453-4057qib7 3444 13 MAC MAC NNP cord-005453-4057qib7 3444 14 ) ) -RRB- cord-005453-4057qib7 3444 15 , , , cord-005453-4057qib7 3444 16 reduced reduce VBN cord-005453-4057qib7 3444 17 intensity intensity NN cord-005453-4057qib7 3444 18 ( ( -LRB- cord-005453-4057qib7 3444 19 RIC RIC NNP cord-005453-4057qib7 3444 20 ) ) -RRB- cord-005453-4057qib7 3444 21 or or CC cord-005453-4057qib7 3444 22 reduced reduce VBN cord-005453-4057qib7 3444 23 toxicity toxicity NN cord-005453-4057qib7 3444 24 ( ( -LRB- cord-005453-4057qib7 3444 25 RTC RTC NNP cord-005453-4057qib7 3444 26 ) ) -RRB- cord-005453-4057qib7 3444 27 . . . cord-005453-4057qib7 3445 1 The the DT cord-005453-4057qib7 3445 2 latter latter JJ cord-005453-4057qib7 3445 3 category category NN cord-005453-4057qib7 3445 4 included include VBD cord-005453-4057qib7 3445 5 only only RB cord-005453-4057qib7 3445 6 patients patient NNS cord-005453-4057qib7 3445 7 receiving receive VBG cord-005453-4057qib7 3445 8 Fludarabine Fludarabine NNP cord-005453-4057qib7 3445 9 and and CC cord-005453-4057qib7 3445 10 Treosulfan Treosulfan NNP cord-005453-4057qib7 3445 11 at at IN cord-005453-4057qib7 3445 12 dose dose NN cord-005453-4057qib7 3445 13 of of IN cord-005453-4057qib7 3445 14 30 30 CD cord-005453-4057qib7 3445 15 - - SYM cord-005453-4057qib7 3445 16 42 42 CD cord-005453-4057qib7 3445 17 g g NN cord-005453-4057qib7 3445 18 / / SYM cord-005453-4057qib7 3445 19 m2 m2 NNP cord-005453-4057qib7 3445 20 ( ( -LRB- cord-005453-4057qib7 3445 21 Flu Flu NNP cord-005453-4057qib7 3445 22 / / SYM cord-005453-4057qib7 3445 23 Treo Treo NNP cord-005453-4057qib7 3445 24 ) ) -RRB- cord-005453-4057qib7 3445 25 . . . cord-005453-4057qib7 3446 1 Risk risk NN cord-005453-4057qib7 3446 2 factors factor NNS cord-005453-4057qib7 3446 3 for for IN cord-005453-4057qib7 3446 4 the the DT cord-005453-4057qib7 3446 5 development development NN cord-005453-4057qib7 3446 6 of of IN cord-005453-4057qib7 3446 7 severe severe JJ cord-005453-4057qib7 3446 8 OM om NN cord-005453-4057qib7 3446 9 were be VBD cord-005453-4057qib7 3446 10 initially initially RB cord-005453-4057qib7 3446 11 identified identify VBN cord-005453-4057qib7 3446 12 by by IN cord-005453-4057qib7 3446 13 a a DT cord-005453-4057qib7 3446 14 univariate univariate JJ cord-005453-4057qib7 3446 15 analysis analysis NN cord-005453-4057qib7 3446 16 and and CC cord-005453-4057qib7 3446 17 then then RB cord-005453-4057qib7 3446 18 analyzed analyze VBD cord-005453-4057qib7 3446 19 in in IN cord-005453-4057qib7 3446 20 a a DT cord-005453-4057qib7 3446 21 multivariate multivariate JJ cord-005453-4057qib7 3446 22 logistic logistic JJ cord-005453-4057qib7 3446 23 regression regression NN cord-005453-4057qib7 3446 24 model model NN cord-005453-4057qib7 3446 25 . . . cord-005453-4057qib7 3447 1 Association Association NNP cord-005453-4057qib7 3447 2 of of IN cord-005453-4057qib7 3447 3 OM OM NNP cord-005453-4057qib7 3447 4 with with IN cord-005453-4057qib7 3447 5 peritransplant peritransplant JJ cord-005453-4057qib7 3447 6 infectious infectious JJ cord-005453-4057qib7 3447 7 complications complication NNS cord-005453-4057qib7 3447 8 , , , cord-005453-4057qib7 3447 9 IV IV NNP cord-005453-4057qib7 3447 10 morphine morphine NN cord-005453-4057qib7 3447 11 consumption consumption NN cord-005453-4057qib7 3447 12 , , , cord-005453-4057qib7 3447 13 hospitalization hospitalization NN cord-005453-4057qib7 3447 14 length length NN cord-005453-4057qib7 3447 15 , , , cord-005453-4057qib7 3447 16 neutrophil neutrophil NN cord-005453-4057qib7 3447 17 engraftment engraftment NN cord-005453-4057qib7 3447 18 , , , cord-005453-4057qib7 3447 19 acute acute JJ cord-005453-4057qib7 3447 20 and and CC cord-005453-4057qib7 3447 21 chronic chronic JJ cord-005453-4057qib7 3447 22 graft graft NN cord-005453-4057qib7 3447 23 - - HYPH cord-005453-4057qib7 3447 24 versus versus IN cord-005453-4057qib7 3447 25 - - HYPH cord-005453-4057qib7 3447 26 host host NN cord-005453-4057qib7 3447 27 disease disease NN cord-005453-4057qib7 3447 28 ( ( -LRB- cord-005453-4057qib7 3447 29 GVHD GVHD NNP cord-005453-4057qib7 3447 30 ) ) -RRB- cord-005453-4057qib7 3447 31 , , , cord-005453-4057qib7 3447 32 non non JJ cord-005453-4057qib7 3447 33 - - JJ cord-005453-4057qib7 3447 34 relapse relapse JJ cord-005453-4057qib7 3447 35 mortality mortality NN cord-005453-4057qib7 3447 36 ( ( -LRB- cord-005453-4057qib7 3447 37 NRM NRM NNP cord-005453-4057qib7 3447 38 ) ) -RRB- cord-005453-4057qib7 3447 39 and and CC cord-005453-4057qib7 3447 40 overall overall JJ cord-005453-4057qib7 3447 41 survival survival NN cord-005453-4057qib7 3447 42 were be VBD cord-005453-4057qib7 3447 43 assessed assess VBN cord-005453-4057qib7 3447 44 in in IN cord-005453-4057qib7 3447 45 a a DT cord-005453-4057qib7 3447 46 univariate univariate JJ cord-005453-4057qib7 3447 47 analysis analysis NN cord-005453-4057qib7 3447 48 . . . cord-005453-4057qib7 3448 1 Competing compete VBG cord-005453-4057qib7 3448 2 events event NNS cord-005453-4057qib7 3448 3 were be VBD cord-005453-4057qib7 3448 4 considered consider VBN cord-005453-4057qib7 3448 5 in in IN cord-005453-4057qib7 3448 6 analyzing analyze VBG cord-005453-4057qib7 3448 7 engraftment engraftment NN cord-005453-4057qib7 3448 8 , , , cord-005453-4057qib7 3448 9 GVHD GVHD NNP cord-005453-4057qib7 3448 10 , , , cord-005453-4057qib7 3448 11 and and CC cord-005453-4057qib7 3448 12 NRM NRM NNP cord-005453-4057qib7 3448 13 . . . cord-005453-4057qib7 3449 1 Results result NNS cord-005453-4057qib7 3449 2 : : : cord-005453-4057qib7 3449 3 115 115 CD cord-005453-4057qib7 3449 4 patients patient NNS cord-005453-4057qib7 3449 5 who who WP cord-005453-4057qib7 3449 6 underwent undergo VBD cord-005453-4057qib7 3449 7 an an DT cord-005453-4057qib7 3449 8 allogeneic allogeneic JJ cord-005453-4057qib7 3449 9 SCT SCT NNP cord-005453-4057qib7 3449 10 between between IN cord-005453-4057qib7 3449 11 2016 2016 CD cord-005453-4057qib7 3449 12 and and CC cord-005453-4057qib7 3449 13 2017 2017 CD cord-005453-4057qib7 3449 14 were be VBD cord-005453-4057qib7 3449 15 included include VBN cord-005453-4057qib7 3449 16 . . . cord-005453-4057qib7 3450 1 Median median JJ cord-005453-4057qib7 3450 2 follow follow NN cord-005453-4057qib7 3450 3 - - HYPH cord-005453-4057qib7 3450 4 up up NN cord-005453-4057qib7 3450 5 was be VBD cord-005453-4057qib7 3450 6 316 316 CD cord-005453-4057qib7 3450 7 days day NNS cord-005453-4057qib7 3450 8 . . . cord-005453-4057qib7 3451 1 Leading lead VBG cord-005453-4057qib7 3451 2 indications indication NNS cord-005453-4057qib7 3451 3 for for IN cord-005453-4057qib7 3451 4 transplantation transplantation NN cord-005453-4057qib7 3451 5 were be VBD cord-005453-4057qib7 3451 6 acute acute JJ cord-005453-4057qib7 3451 7 myeloid myeloid JJ cord-005453-4057qib7 3451 8 leukemia leukemia NN cord-005453-4057qib7 3451 9 ( ( -LRB- cord-005453-4057qib7 3451 10 49 49 CD cord-005453-4057qib7 3451 11 % % NN cord-005453-4057qib7 3451 12 ) ) -RRB- cord-005453-4057qib7 3451 13 , , , cord-005453-4057qib7 3451 14 lymphoma lymphoma NN cord-005453-4057qib7 3451 15 ( ( -LRB- cord-005453-4057qib7 3451 16 16 16 CD cord-005453-4057qib7 3451 17 % % NN cord-005453-4057qib7 3451 18 ) ) -RRB- cord-005453-4057qib7 3451 19 , , , cord-005453-4057qib7 3451 20 and and CC cord-005453-4057qib7 3451 21 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 3451 22 syndrome syndrome NN cord-005453-4057qib7 3451 23 ( ( -LRB- cord-005453-4057qib7 3451 24 15 15 CD cord-005453-4057qib7 3451 25 % % NN cord-005453-4057qib7 3451 26 ) ) -RRB- cord-005453-4057qib7 3451 27 . . . cord-005453-4057qib7 3452 1 The the DT cord-005453-4057qib7 3452 2 majority majority NN cord-005453-4057qib7 3452 3 of of IN cord-005453-4057qib7 3452 4 patients patient NNS cord-005453-4057qib7 3452 5 received receive VBD cord-005453-4057qib7 3452 6 an an DT cord-005453-4057qib7 3452 7 allograft allograft NN cord-005453-4057qib7 3452 8 from from IN cord-005453-4057qib7 3452 9 a a DT cord-005453-4057qib7 3452 10 matched match VBN cord-005453-4057qib7 3452 11 sibling sibling NN cord-005453-4057qib7 3452 12 or or CC cord-005453-4057qib7 3452 13 unrelated unrelated JJ cord-005453-4057qib7 3452 14 donor donor NN cord-005453-4057qib7 3452 15 ( ( -LRB- cord-005453-4057qib7 3452 16 88 88 CD cord-005453-4057qib7 3452 17 % % NN cord-005453-4057qib7 3452 18 ) ) -RRB- cord-005453-4057qib7 3452 19 and and CC cord-005453-4057qib7 3452 20 methotrexate methotrexate NNP cord-005453-4057qib7 3452 21 GVHD GVHD NNP cord-005453-4057qib7 3452 22 prophylaxis prophylaxis NN cord-005453-4057qib7 3452 23 ( ( -LRB- cord-005453-4057qib7 3452 24 74 74 CD cord-005453-4057qib7 3452 25 % % NN cord-005453-4057qib7 3452 26 ) ) -RRB- cord-005453-4057qib7 3452 27 . . . cord-005453-4057qib7 3453 1 The the DT cord-005453-4057qib7 3453 2 median median JJ cord-005453-4057qib7 3453 3 time time NN cord-005453-4057qib7 3453 4 to to IN cord-005453-4057qib7 3453 5 OM OM NNP cord-005453-4057qib7 3453 6 onset onset NN cord-005453-4057qib7 3453 7 was be VBD cord-005453-4057qib7 3453 8 7 7 CD cord-005453-4057qib7 3453 9 ( ( -LRB- cord-005453-4057qib7 3453 10 interquartile interquartile JJ cord-005453-4057qib7 3453 11 range range NN cord-005453-4057qib7 3453 12 [ [ -LRB- cord-005453-4057qib7 3453 13 IQR IQR NNP cord-005453-4057qib7 3453 14 ] ] -RRB- cord-005453-4057qib7 3453 15 5 5 CD cord-005453-4057qib7 3453 16 - - SYM cord-005453-4057qib7 3453 17 9 9 CD cord-005453-4057qib7 3453 18 ) ) -RRB- cord-005453-4057qib7 3453 19 days day NNS cord-005453-4057qib7 3453 20 . . . cord-005453-4057qib7 3454 1 Prevalence prevalence NN cord-005453-4057qib7 3454 2 of of IN cord-005453-4057qib7 3454 3 grade grade NN cord-005453-4057qib7 3454 4 II II NNP cord-005453-4057qib7 3454 5 - - HYPH cord-005453-4057qib7 3454 6 IV IV NNP cord-005453-4057qib7 3454 7 OM OM NNP cord-005453-4057qib7 3454 8 was be VBD cord-005453-4057qib7 3454 9 60 60 CD cord-005453-4057qib7 3454 10 % % NN cord-005453-4057qib7 3454 11 . . . cord-005453-4057qib7 3455 1 The the DT cord-005453-4057qib7 3455 2 median median JJ cord-005453-4057qib7 3455 3 duration duration NN cord-005453-4057qib7 3455 4 OM OM NNP cord-005453-4057qib7 3455 5 was be VBD cord-005453-4057qib7 3455 6 10 10 CD cord-005453-4057qib7 3455 7 [ [ -LRB- cord-005453-4057qib7 3455 8 6 6 CD cord-005453-4057qib7 3455 9 - - SYM cord-005453-4057qib7 3455 10 13 13 CD cord-005453-4057qib7 3455 11 ] ] -RRB- cord-005453-4057qib7 3455 12 days day NNS cord-005453-4057qib7 3455 13 , , , cord-005453-4057qib7 3455 14 and and CC cord-005453-4057qib7 3455 15 IV IV NNP cord-005453-4057qib7 3455 16 morphine morphine NN cord-005453-4057qib7 3455 17 was be VBD cord-005453-4057qib7 3455 18 administrated administrate VBN cord-005453-4057qib7 3455 19 for for IN cord-005453-4057qib7 3455 20 a a DT cord-005453-4057qib7 3455 21 median median NN cord-005453-4057qib7 3455 22 of of IN cord-005453-4057qib7 3455 23 5 5 CD cord-005453-4057qib7 3455 24 [ [ -LRB- cord-005453-4057qib7 3455 25 6 6 CD cord-005453-4057qib7 3455 26 - - SYM cord-005453-4057qib7 3455 27 12 12 CD cord-005453-4057qib7 3455 28 ] ] -RRB- cord-005453-4057qib7 3455 29 days day NNS cord-005453-4057qib7 3455 30 for for IN cord-005453-4057qib7 3455 31 patients patient NNS cord-005453-4057qib7 3455 32 with with IN cord-005453-4057qib7 3455 33 grades grade NNS cord-005453-4057qib7 3455 34 III III NNP cord-005453-4057qib7 3455 35 - - HYPH cord-005453-4057qib7 3455 36 IV IV NNP cord-005453-4057qib7 3455 37 OM OM NNP cord-005453-4057qib7 3455 38 ( ( -LRB- cord-005453-4057qib7 3455 39 45 45 CD cord-005453-4057qib7 3455 40 % % NN cord-005453-4057qib7 3455 41 ) ) -RRB- cord-005453-4057qib7 3455 42 . . . cord-005453-4057qib7 3456 1 In in IN cord-005453-4057qib7 3456 2 a a DT cord-005453-4057qib7 3456 3 univariate univariate JJ cord-005453-4057qib7 3456 4 analysis analysis NN cord-005453-4057qib7 3456 5 a a DT cord-005453-4057qib7 3456 6 younger young JJR cord-005453-4057qib7 3456 7 age age NN cord-005453-4057qib7 3456 8 ( ( -LRB- cord-005453-4057qib7 3456 9 p=0.023 p=0.023 NNS cord-005453-4057qib7 3456 10 ) ) -RRB- cord-005453-4057qib7 3456 11 , , , cord-005453-4057qib7 3456 12 lower low JJR cord-005453-4057qib7 3456 13 BMI BMI NNP cord-005453-4057qib7 3456 14 ( ( -LRB- cord-005453-4057qib7 3456 15 p=0.01 p=0.01 NNP cord-005453-4057qib7 3456 16 ) ) -RRB- cord-005453-4057qib7 3456 17 , , , cord-005453-4057qib7 3456 18 recent recent JJ cord-005453-4057qib7 3456 19 smoking smoking NN cord-005453-4057qib7 3456 20 history history NN cord-005453-4057qib7 3456 21 ( ( -LRB- cord-005453-4057qib7 3456 22 p=0.08 p=0.08 NNP cord-005453-4057qib7 3456 23 ) ) -RRB- cord-005453-4057qib7 3456 24 , , , cord-005453-4057qib7 3456 25 recent recent JJ cord-005453-4057qib7 3456 26 antibiotics antibiotic NNS cord-005453-4057qib7 3456 27 exposure exposure NN cord-005453-4057qib7 3456 28 ( ( -LRB- cord-005453-4057qib7 3456 29 p=0.018 p=0.018 NNP cord-005453-4057qib7 3456 30 ) ) -RRB- cord-005453-4057qib7 3456 31 , , , cord-005453-4057qib7 3456 32 MAC MAC NNP cord-005453-4057qib7 3456 33 ( ( -LRB- cord-005453-4057qib7 3456 34 p p NN cord-005453-4057qib7 3456 35 < < XX cord-005453-4057qib7 3456 36 0.001 0.001 CD cord-005453-4057qib7 3456 37 ) ) -RRB- cord-005453-4057qib7 3456 38 , , , cord-005453-4057qib7 3456 39 and and CC cord-005453-4057qib7 3456 40 use use NN cord-005453-4057qib7 3456 41 of of IN cord-005453-4057qib7 3456 42 methotrexate methotrexate NNP cord-005453-4057qib7 3456 43 ( ( -LRB- cord-005453-4057qib7 3456 44 p=0.009 p=0.009 NN cord-005453-4057qib7 3456 45 ) ) -RRB- cord-005453-4057qib7 3456 46 were be VBD cord-005453-4057qib7 3456 47 associated associate VBN cord-005453-4057qib7 3456 48 with with IN cord-005453-4057qib7 3456 49 an an DT cord-005453-4057qib7 3456 50 increased increase VBN cord-005453-4057qib7 3456 51 risk risk NN cord-005453-4057qib7 3456 52 for for IN cord-005453-4057qib7 3456 53 grade grade NN cord-005453-4057qib7 3456 54 II II NNP cord-005453-4057qib7 3456 55 - - HYPH cord-005453-4057qib7 3456 56 IV IV NNP cord-005453-4057qib7 3456 57 OM om NN cord-005453-4057qib7 3456 58 . . . cord-005453-4057qib7 3457 1 In in IN cord-005453-4057qib7 3457 2 a a DT cord-005453-4057qib7 3457 3 multivariable multivariable JJ cord-005453-4057qib7 3457 4 model model NN cord-005453-4057qib7 3457 5 the the DT cord-005453-4057qib7 3457 6 risk risk NN cord-005453-4057qib7 3457 7 for for IN cord-005453-4057qib7 3457 8 grade grade NN cord-005453-4057qib7 3457 9 II II NNP cord-005453-4057qib7 3457 10 - - HYPH cord-005453-4057qib7 3457 11 IV IV NNP cord-005453-4057qib7 3457 12 OM OM NNP cord-005453-4057qib7 3457 13 was be VBD cord-005453-4057qib7 3457 14 lower low JJR cord-005453-4057qib7 3457 15 with with IN cord-005453-4057qib7 3457 16 RTC RTC NNP cord-005453-4057qib7 3457 17 ( ( -LRB- cord-005453-4057qib7 3457 18 i.e. i.e. FW cord-005453-4057qib7 3457 19 , , , cord-005453-4057qib7 3457 20 Flu Flu NNP cord-005453-4057qib7 3457 21 / / SYM cord-005453-4057qib7 3457 22 Treo Treo NNP cord-005453-4057qib7 3457 23 ) ) -RRB- cord-005453-4057qib7 3457 24 vs. vs. IN cord-005453-4057qib7 3457 25 MAC MAC NNP cord-005453-4057qib7 3457 26 ( ( -LRB- cord-005453-4057qib7 3457 27 odds odd NNS cord-005453-4057qib7 3457 28 ratio ratio NN cord-005453-4057qib7 3457 29 [ [ -LRB- cord-005453-4057qib7 3457 30 OR or CC cord-005453-4057qib7 3457 31 ] ] -RRB- cord-005453-4057qib7 3457 32 27.31 27.31 CD cord-005453-4057qib7 3457 33 ; ; : cord-005453-4057qib7 3457 34 p p NN cord-005453-4057qib7 3457 35 < < XX cord-005453-4057qib7 3457 36 0.001 0.001 CD cord-005453-4057qib7 3457 37 ) ) -RRB- cord-005453-4057qib7 3457 38 and and CC cord-005453-4057qib7 3457 39 RTC RTC NNP cord-005453-4057qib7 3457 40 vs vs IN cord-005453-4057qib7 3457 41 RIC RIC NNP cord-005453-4057qib7 3457 42 ( ( -LRB- cord-005453-4057qib7 3457 43 OR OR NNP cord-005453-4057qib7 3457 44 7.25 7.25 CD cord-005453-4057qib7 3457 45 ; ; : cord-005453-4057qib7 3457 46 p=0.001 p=0.001 NNP cord-005453-4057qib7 3457 47 ) ) -RRB- cord-005453-4057qib7 3457 48 , , , cord-005453-4057qib7 3457 49 mycophenolate mycophenolate NNP cord-005453-4057qib7 3457 50 mofetil mofetil NNP cord-005453-4057qib7 3457 51 vs. vs. FW cord-005453-4057qib7 3457 52 methotrexate methotrexate NNP cord-005453-4057qib7 3457 53 ( ( -LRB- cord-005453-4057qib7 3457 54 OR or CC cord-005453-4057qib7 3457 55 3.43 3.43 CD cord-005453-4057qib7 3457 56 ; ; : cord-005453-4057qib7 3457 57 p=0.027 p=0.027 NNP cord-005453-4057qib7 3457 58 ) ) -RRB- cord-005453-4057qib7 3457 59 and and CC cord-005453-4057qib7 3457 60 recent recent JJ cord-005453-4057qib7 3457 61 smoking smoking NN cord-005453-4057qib7 3457 62 ( ( -LRB- cord-005453-4057qib7 3457 63 OR OR NNP cord-005453-4057qib7 3457 64 4.7 4.7 CD cord-005453-4057qib7 3457 65 ; ; : cord-005453-4057qib7 3457 66 p=0.075 p=0.075 NNP cord-005453-4057qib7 3457 67 ) ) -RRB- cord-005453-4057qib7 3457 68 . . . cord-005453-4057qib7 3458 1 Compared compare VBN cord-005453-4057qib7 3458 2 to to IN cord-005453-4057qib7 3458 3 lower low JJR cord-005453-4057qib7 3458 4 grades grade NNS cord-005453-4057qib7 3458 5 , , , cord-005453-4057qib7 3458 6 grade grade NN cord-005453-4057qib7 3458 7 II II NNP cord-005453-4057qib7 3458 8 - - HYPH cord-005453-4057qib7 3458 9 IV IV NNP cord-005453-4057qib7 3458 10 OM OM NNP cord-005453-4057qib7 3458 11 was be VBD cord-005453-4057qib7 3458 12 associated associate VBN cord-005453-4057qib7 3458 13 with with IN cord-005453-4057qib7 3458 14 a a DT cord-005453-4057qib7 3458 15 longer long JJR cord-005453-4057qib7 3458 16 hospitalization hospitalization NN cord-005453-4057qib7 3458 17 duration duration NN cord-005453-4057qib7 3458 18 ( ( -LRB- cord-005453-4057qib7 3458 19 median median JJ cord-005453-4057qib7 3458 20 29 29 CD cord-005453-4057qib7 3458 21 days day NNS cord-005453-4057qib7 3458 22 vs. vs. IN cord-005453-4057qib7 3458 23 27 27 CD cord-005453-4057qib7 3458 24 days day NNS cord-005453-4057qib7 3458 25 ; ; : cord-005453-4057qib7 3458 26 p=0.006 p=0.006 NNS cord-005453-4057qib7 3458 27 ) ) -RRB- cord-005453-4057qib7 3458 28 , , , cord-005453-4057qib7 3458 29 delayed delay VBN cord-005453-4057qib7 3458 30 neutrophil neutrophil NN cord-005453-4057qib7 3458 31 engraftment engraftment NN cord-005453-4057qib7 3458 32 ( ( -LRB- cord-005453-4057qib7 3458 33 median median NN cord-005453-4057qib7 3458 34 14 14 CD cord-005453-4057qib7 3458 35 vs. vs. NN cord-005453-4057qib7 3458 36 12 12 CD cord-005453-4057qib7 3458 37 days day NNS cord-005453-4057qib7 3458 38 ; ; : cord-005453-4057qib7 3458 39 p=-0.004 p=-0.004 NNP cord-005453-4057qib7 3458 40 ) ) -RRB- cord-005453-4057qib7 3458 41 , , , cord-005453-4057qib7 3458 42 and and CC cord-005453-4057qib7 3458 43 more more RBR cord-005453-4057qib7 3458 44 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 3458 45 related relate VBN cord-005453-4057qib7 3458 46 infections infection NNS cord-005453-4057qib7 3458 47 ( ( -LRB- cord-005453-4057qib7 3458 48 10 10 CD cord-005453-4057qib7 3458 49 % % NN cord-005453-4057qib7 3458 50 vs. vs. CC cord-005453-4057qib7 3458 51 0 0 CD cord-005453-4057qib7 3458 52 % % NN cord-005453-4057qib7 3458 53 ; ; : cord-005453-4057qib7 3458 54 p=0.045 p=0.045 NNP cord-005453-4057qib7 3458 55 ) ) -RRB- cord-005453-4057qib7 3458 56 . . . cord-005453-4057qib7 3459 1 Grade Grade NNP cord-005453-4057qib7 3459 2 II II NNP cord-005453-4057qib7 3459 3 - - HYPH cord-005453-4057qib7 3459 4 IV IV NNP cord-005453-4057qib7 3459 5 OM OM NNP cord-005453-4057qib7 3459 6 was be VBD cord-005453-4057qib7 3459 7 not not RB cord-005453-4057qib7 3459 8 associated associate VBN cord-005453-4057qib7 3459 9 with with IN cord-005453-4057qib7 3459 10 increased increase VBN cord-005453-4057qib7 3459 11 risk risk NN cord-005453-4057qib7 3459 12 of of IN cord-005453-4057qib7 3459 13 bloodstream bloodstream NN cord-005453-4057qib7 3459 14 infections infection NNS cord-005453-4057qib7 3459 15 , , , cord-005453-4057qib7 3459 16 acute acute JJ cord-005453-4057qib7 3459 17 or or CC cord-005453-4057qib7 3459 18 chronic chronic JJ cord-005453-4057qib7 3459 19 GVHD GVHD NNP cord-005453-4057qib7 3459 20 , , , cord-005453-4057qib7 3459 21 non non JJ cord-005453-4057qib7 3459 22 - - JJ cord-005453-4057qib7 3459 23 relapse relapse JJ cord-005453-4057qib7 3459 24 mortality mortality NN cord-005453-4057qib7 3459 25 , , , cord-005453-4057qib7 3459 26 and and CC cord-005453-4057qib7 3459 27 increased increase VBN cord-005453-4057qib7 3459 28 mortality mortality NN cord-005453-4057qib7 3459 29 . . . cord-005453-4057qib7 3460 1 Conclusions conclusion NNS cord-005453-4057qib7 3460 2 : : : cord-005453-4057qib7 3461 1 Oral oral JJ cord-005453-4057qib7 3461 2 mucositis mucositis NNP cord-005453-4057qib7 3461 3 is be VBZ cord-005453-4057qib7 3461 4 prevalent prevalent JJ cord-005453-4057qib7 3461 5 among among IN cord-005453-4057qib7 3461 6 allogeneic allogeneic NN cord-005453-4057qib7 3461 7 - - HYPH cord-005453-4057qib7 3461 8 SCT SCT NNP cord-005453-4057qib7 3461 9 recipients recipient NNS cord-005453-4057qib7 3461 10 . . . cord-005453-4057qib7 3462 1 Importantly importantly RB cord-005453-4057qib7 3462 2 , , , cord-005453-4057qib7 3462 3 fludarabine fludarabine NN cord-005453-4057qib7 3462 4 - - HYPH cord-005453-4057qib7 3462 5 treosulfan treosulfan NNP cord-005453-4057qib7 3462 6 , , , cord-005453-4057qib7 3462 7 which which WDT cord-005453-4057qib7 3462 8 is be VBZ cord-005453-4057qib7 3462 9 considered consider VBN cord-005453-4057qib7 3462 10 a a DT cord-005453-4057qib7 3462 11 myeloablative myeloablative NN cord-005453-4057qib7 3462 12 is be VBZ cord-005453-4057qib7 3462 13 associated associate VBN cord-005453-4057qib7 3462 14 with with IN cord-005453-4057qib7 3462 15 a a DT cord-005453-4057qib7 3462 16 markedly markedly RB cord-005453-4057qib7 3462 17 reduced reduce VBN cord-005453-4057qib7 3462 18 risk risk NN cord-005453-4057qib7 3462 19 for for IN cord-005453-4057qib7 3462 20 OM OM NNP cord-005453-4057qib7 3462 21 . . . cord-005453-4057qib7 3463 1 Consequences consequence NNS cord-005453-4057qib7 3463 2 of of IN cord-005453-4057qib7 3463 3 OM OM NNP cord-005453-4057qib7 3463 4 include include VBP cord-005453-4057qib7 3463 5 prolongation prolongation NN cord-005453-4057qib7 3463 6 of of IN cord-005453-4057qib7 3463 7 hospitalization hospitalization NN cord-005453-4057qib7 3463 8 , , , cord-005453-4057qib7 3463 9 delay delay VBP cord-005453-4057qib7 3463 10 in in IN cord-005453-4057qib7 3463 11 neutrophil neutrophil NN cord-005453-4057qib7 3463 12 engraftment engraftment NN cord-005453-4057qib7 3463 13 , , , cord-005453-4057qib7 3463 14 and and CC cord-005453-4057qib7 3463 15 a a DT cord-005453-4057qib7 3463 16 tendency tendency NN cord-005453-4057qib7 3463 17 for for IN cord-005453-4057qib7 3463 18 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 3463 19 infections infection NNS cord-005453-4057qib7 3463 20 , , , cord-005453-4057qib7 3463 21 but but CC cord-005453-4057qib7 3463 22 does do VBZ cord-005453-4057qib7 3463 23 not not RB cord-005453-4057qib7 3463 24 increase increase VB cord-005453-4057qib7 3463 25 the the DT cord-005453-4057qib7 3463 26 risk risk NN cord-005453-4057qib7 3463 27 for for IN cord-005453-4057qib7 3463 28 GVHD GVHD NNP cord-005453-4057qib7 3463 29 and and CC cord-005453-4057qib7 3463 30 mortality mortality NN cord-005453-4057qib7 3463 31 . . . cord-005453-4057qib7 3464 1 Disclosure disclosure NN cord-005453-4057qib7 3464 2 : : : cord-005453-4057qib7 3464 3 Nothing nothing NN cord-005453-4057qib7 3464 4 to to TO cord-005453-4057qib7 3464 5 declare declare VB cord-005453-4057qib7 3464 6 Background background NN cord-005453-4057qib7 3464 7 : : : cord-005453-4057qib7 3465 1 The the DT cord-005453-4057qib7 3465 2 advent advent NN cord-005453-4057qib7 3465 3 of of IN cord-005453-4057qib7 3465 4 recent recent JJ cord-005453-4057qib7 3465 5 diagnostic diagnostic JJ cord-005453-4057qib7 3465 6 techniques technique NNS cord-005453-4057qib7 3465 7 for for IN cord-005453-4057qib7 3465 8 the the DT cord-005453-4057qib7 3465 9 assessment assessment NN cord-005453-4057qib7 3465 10 of of IN cord-005453-4057qib7 3465 11 iron iron NN cord-005453-4057qib7 3465 12 overload overload NN cord-005453-4057qib7 3465 13 ( ( -LRB- cord-005453-4057qib7 3465 14 T2 T2 NNP cord-005453-4057qib7 3465 15 * * NFP cord-005453-4057qib7 3465 16 -MRI -MRI NFP cord-005453-4057qib7 3465 17 ) ) -RRB- cord-005453-4057qib7 3465 18 and and CC cord-005453-4057qib7 3465 19 their -PRON- PRP$ cord-005453-4057qib7 3465 20 systematic systematic JJ cord-005453-4057qib7 3465 21 use use NN cord-005453-4057qib7 3465 22 as as IN cord-005453-4057qib7 3465 23 screening screening NN cord-005453-4057qib7 3465 24 tools tool NNS cord-005453-4057qib7 3465 25 in in IN cord-005453-4057qib7 3465 26 the the DT cord-005453-4057qib7 3465 27 setting setting NN cord-005453-4057qib7 3465 28 of of IN cord-005453-4057qib7 3465 29 secondary secondary JJ cord-005453-4057qib7 3465 30 hemochromatosis hemochromatosis NN cord-005453-4057qib7 3465 31 have have VBP cord-005453-4057qib7 3465 32 led lead VBN cord-005453-4057qib7 3465 33 to to IN cord-005453-4057qib7 3465 34 an an DT cord-005453-4057qib7 3465 35 increased increase VBN cord-005453-4057qib7 3465 36 awareness awareness NN cord-005453-4057qib7 3465 37 that that IN cord-005453-4057qib7 3465 38 focal focal JJ cord-005453-4057qib7 3465 39 nodular nodular JJ cord-005453-4057qib7 3465 40 hyperplasia hyperplasia NN cord-005453-4057qib7 3465 41 ( ( -LRB- cord-005453-4057qib7 3465 42 FNH FNH NNP cord-005453-4057qib7 3465 43 ) ) -RRB- cord-005453-4057qib7 3465 44 represents represent VBZ cord-005453-4057qib7 3465 45 a a DT cord-005453-4057qib7 3465 46 possible possible JJ cord-005453-4057qib7 3465 47 incidental incidental JJ cord-005453-4057qib7 3465 48 finding finding NN cord-005453-4057qib7 3465 49 after after IN cord-005453-4057qib7 3465 50 hematopoietic hematopoietic JJ cord-005453-4057qib7 3465 51 stem stem NN cord-005453-4057qib7 3465 52 cell cell NN cord-005453-4057qib7 3465 53 transplantation transplantation NN cord-005453-4057qib7 3465 54 ( ( -LRB- cord-005453-4057qib7 3465 55 HSCT HSCT NNP cord-005453-4057qib7 3465 56 ) ) -RRB- cord-005453-4057qib7 3465 57 . . . cord-005453-4057qib7 3466 1 Methods method NNS cord-005453-4057qib7 3466 2 : : : cord-005453-4057qib7 3466 3 Clinical clinical JJ cord-005453-4057qib7 3466 4 and and CC cord-005453-4057qib7 3466 5 radiological radiological JJ cord-005453-4057qib7 3466 6 features feature NNS cord-005453-4057qib7 3466 7 of of IN cord-005453-4057qib7 3466 8 patients patient NNS cord-005453-4057qib7 3466 9 undergoing undergo VBG cord-005453-4057qib7 3466 10 HSCT HSCT NNP cord-005453-4057qib7 3466 11 in in IN cord-005453-4057qib7 3466 12 a a DT cord-005453-4057qib7 3466 13 single single JJ cord-005453-4057qib7 3466 14 pediatric pediatric JJ cord-005453-4057qib7 3466 15 institution institution NN cord-005453-4057qib7 3466 16 have have VBP cord-005453-4057qib7 3466 17 been be VBN cord-005453-4057qib7 3466 18 retrospectively retrospectively RB cord-005453-4057qib7 3466 19 reviewed review VBN cord-005453-4057qib7 3466 20 for for IN cord-005453-4057qib7 3466 21 FNH FNH NNP cord-005453-4057qib7 3466 22 . . . cord-005453-4057qib7 3467 1 In in IN cord-005453-4057qib7 3467 2 order order NN cord-005453-4057qib7 3467 3 to to TO cord-005453-4057qib7 3467 4 provide provide VB cord-005453-4057qib7 3467 5 an an DT cord-005453-4057qib7 3467 6 estimate estimate NN cord-005453-4057qib7 3467 7 of of IN cord-005453-4057qib7 3467 8 the the DT cord-005453-4057qib7 3467 9 prevalence prevalence NN cord-005453-4057qib7 3467 10 of of IN cord-005453-4057qib7 3467 11 FNH FNH NNP cord-005453-4057qib7 3467 12 after after IN cord-005453-4057qib7 3467 13 HSCT HSCT NNP cord-005453-4057qib7 3467 14 , , , cord-005453-4057qib7 3467 15 we -PRON- PRP cord-005453-4057qib7 3467 16 analysed analyse VBD cord-005453-4057qib7 3467 17 all all PDT cord-005453-4057qib7 3467 18 the the DT cord-005453-4057qib7 3467 19 T2 T2 NNP cord-005453-4057qib7 3467 20 * * NFP cord-005453-4057qib7 3467 21 -MRI -mri WDT cord-005453-4057qib7 3467 22 scans scan NNS cord-005453-4057qib7 3467 23 performed perform VBN cord-005453-4057qib7 3467 24 during during IN cord-005453-4057qib7 3467 25 the the DT cord-005453-4057qib7 3467 26 last last JJ cord-005453-4057qib7 3467 27 5 5 CD cord-005453-4057qib7 3467 28 years year NNS cord-005453-4057qib7 3467 29 in in IN cord-005453-4057qib7 3467 30 our -PRON- PRP$ cord-005453-4057qib7 3467 31 Centre Centre NNP cord-005453-4057qib7 3467 32 and and CC cord-005453-4057qib7 3467 33 recorded record VBD cord-005453-4057qib7 3467 34 the the DT cord-005453-4057qib7 3467 35 number number NN cord-005453-4057qib7 3467 36 of of IN cord-005453-4057qib7 3467 37 patients patient NNS cord-005453-4057qib7 3467 38 with with IN cord-005453-4057qib7 3467 39 FNH FNH NNP cord-005453-4057qib7 3467 40 ( ( -LRB- cord-005453-4057qib7 3467 41 group group NN cord-005453-4057qib7 3467 42 A A NNP cord-005453-4057qib7 3467 43 ) ) -RRB- cord-005453-4057qib7 3467 44 . . . cord-005453-4057qib7 3468 1 In in IN cord-005453-4057qib7 3468 2 addition addition NN cord-005453-4057qib7 3468 3 , , , cord-005453-4057qib7 3468 4 data datum NNS cord-005453-4057qib7 3468 5 about about IN cord-005453-4057qib7 3468 6 patients patient NNS cord-005453-4057qib7 3468 7 incidentally incidentally RB cord-005453-4057qib7 3468 8 diagnosed diagnose VBN cord-005453-4057qib7 3468 9 with with IN cord-005453-4057qib7 3468 10 FNH FNH NNP cord-005453-4057qib7 3468 11 at at IN cord-005453-4057qib7 3468 12 abdominal abdominal JJ cord-005453-4057qib7 3468 13 imaging imaging NN cord-005453-4057qib7 3468 14 performed perform VBN cord-005453-4057qib7 3468 15 for for IN cord-005453-4057qib7 3468 16 different different JJ cord-005453-4057qib7 3468 17 clinical clinical JJ cord-005453-4057qib7 3468 18 indications indication NNS cord-005453-4057qib7 3468 19 have have VBP cord-005453-4057qib7 3468 20 been be VBN cord-005453-4057qib7 3468 21 collected collect VBN cord-005453-4057qib7 3468 22 ( ( -LRB- cord-005453-4057qib7 3468 23 group group NN cord-005453-4057qib7 3468 24 B B NNP cord-005453-4057qib7 3468 25 ) ) -RRB- cord-005453-4057qib7 3468 26 . . . cord-005453-4057qib7 3469 1 Results result NNS cord-005453-4057qib7 3469 2 : : : cord-005453-4057qib7 3470 1 Eight eight CD cord-005453-4057qib7 3470 2 out out IN cord-005453-4057qib7 3470 3 of of IN cord-005453-4057qib7 3470 4 118 118 CD cord-005453-4057qib7 3470 5 ( ( -LRB- cord-005453-4057qib7 3470 6 7 7 CD cord-005453-4057qib7 3470 7 % % NN cord-005453-4057qib7 3470 8 ) ) -RRB- cord-005453-4057qib7 3470 9 transplanted transplant VBN cord-005453-4057qib7 3470 10 patients patient NNS cord-005453-4057qib7 3470 11 who who WP cord-005453-4057qib7 3470 12 underwent undergo VBD cord-005453-4057qib7 3470 13 at at RB cord-005453-4057qib7 3470 14 least least RBS cord-005453-4057qib7 3470 15 one one CD cord-005453-4057qib7 3470 16 T2 t2 NN cord-005453-4057qib7 3470 17 * * NFP cord-005453-4057qib7 3470 18 -MRI -MRI -LRB- cord-005453-4057qib7 3470 19 scan scan NN cord-005453-4057qib7 3470 20 from from IN cord-005453-4057qib7 3470 21 September September NNP cord-005453-4057qib7 3470 22 2013 2013 CD cord-005453-4057qib7 3470 23 to to IN cord-005453-4057qib7 3470 24 September September NNP cord-005453-4057qib7 3470 25 2018 2018 CD cord-005453-4057qib7 3470 26 were be VBD cord-005453-4057qib7 3470 27 incidentally incidentally RB cord-005453-4057qib7 3470 28 diagnosed diagnose VBN cord-005453-4057qib7 3470 29 with with IN cord-005453-4057qib7 3470 30 FNH FNH NNP cord-005453-4057qib7 3470 31 . . . cord-005453-4057qib7 3471 1 Group Group NNP cord-005453-4057qib7 3471 2 B B NNP cord-005453-4057qib7 3471 3 included include VBD cord-005453-4057qib7 3471 4 3 3 CD cord-005453-4057qib7 3471 5 subjects subject NNS cord-005453-4057qib7 3471 6 with with IN cord-005453-4057qib7 3471 7 FNH FNH NNP cord-005453-4057qib7 3471 8 incidentally incidentally RB cord-005453-4057qib7 3471 9 found find VBD cord-005453-4057qib7 3471 10 at at IN cord-005453-4057qib7 3471 11 ultrasound ultrasound NN cord-005453-4057qib7 3471 12 or or CC cord-005453-4057qib7 3471 13 non non JJ cord-005453-4057qib7 3471 14 - - JJ cord-005453-4057qib7 3471 15 T2 t2 NN cord-005453-4057qib7 3472 1 * * NFP cord-005453-4057qib7 3472 2 MRI MRI NNP cord-005453-4057qib7 3472 3 scans scan NNS cord-005453-4057qib7 3472 4 performed perform VBN cord-005453-4057qib7 3472 5 before before IN cord-005453-4057qib7 3472 6 2013 2013 CD cord-005453-4057qib7 3472 7 . . . cord-005453-4057qib7 3473 1 Overall overall RB cord-005453-4057qib7 3473 2 , , , cord-005453-4057qib7 3473 3 11 11 CD cord-005453-4057qib7 3473 4 transplanted transplant VBN cord-005453-4057qib7 3473 5 patients patient NNS cord-005453-4057qib7 3473 6 ( ( -LRB- cord-005453-4057qib7 3473 7 5 5 CD cord-005453-4057qib7 3473 8 males male NNS cord-005453-4057qib7 3473 9 , , , cord-005453-4057qib7 3473 10 45 45 CD cord-005453-4057qib7 3473 11 % % NN cord-005453-4057qib7 3473 12 ) ) -RRB- cord-005453-4057qib7 3473 13 , , , cord-005453-4057qib7 3473 14 transplanted transplant VBN cord-005453-4057qib7 3473 15 for for IN cord-005453-4057qib7 3473 16 AL AL NNP cord-005453-4057qib7 3473 17 ( ( -LRB- cord-005453-4057qib7 3473 18 9 9 CD cord-005453-4057qib7 3473 19 cases case NNS cord-005453-4057qib7 3473 20 ) ) -RRB- cord-005453-4057qib7 3473 21 or or CC cord-005453-4057qib7 3473 22 bone bone NN cord-005453-4057qib7 3473 23 marrow marrow NN cord-005453-4057qib7 3473 24 failure failure NN cord-005453-4057qib7 3473 25 ( ( -LRB- cord-005453-4057qib7 3473 26 2 2 CD cord-005453-4057qib7 3473 27 cases case NNS cord-005453-4057qib7 3473 28 ) ) -RRB- cord-005453-4057qib7 3473 29 at at IN cord-005453-4057qib7 3473 30 a a DT cord-005453-4057qib7 3473 31 median median JJ cord-005453-4057qib7 3473 32 age age NN cord-005453-4057qib7 3473 33 of of IN cord-005453-4057qib7 3473 34 13.1±3.6 13.1±3.6 CD cord-005453-4057qib7 3473 35 years year NNS cord-005453-4057qib7 3473 36 , , , cord-005453-4057qib7 3473 37 were be VBD cord-005453-4057qib7 3473 38 diagnosed diagnose VBN cord-005453-4057qib7 3473 39 with with IN cord-005453-4057qib7 3473 40 FNH FNH NNP cord-005453-4057qib7 3473 41 between between IN cord-005453-4057qib7 3473 42 0.6 0.6 CD cord-005453-4057qib7 3473 43 and and CC cord-005453-4057qib7 3473 44 12.8 12.8 CD cord-005453-4057qib7 3473 45 years year NNS cord-005453-4057qib7 3473 46 after after IN cord-005453-4057qib7 3473 47 HSCT HSCT NNP cord-005453-4057qib7 3473 48 , , , cord-005453-4057qib7 3473 49 namely namely RB cord-005453-4057qib7 3473 50 3.2±2.6 3.2±2.6 CD cord-005453-4057qib7 3473 51 years year NNS cord-005453-4057qib7 3473 52 in in IN cord-005453-4057qib7 3473 53 Group Group NNP cord-005453-4057qib7 3473 54 A A NNP cord-005453-4057qib7 3473 55 and and CC cord-005453-4057qib7 3473 56 7.0±4.1 7.0±4.1 CD cord-005453-4057qib7 3473 57 years year NNS cord-005453-4057qib7 3473 58 in in IN cord-005453-4057qib7 3473 59 Group Group NNP cord-005453-4057qib7 3473 60 B. B. NNP cord-005453-4057qib7 3473 61 A A NNP cord-005453-4057qib7 3474 1 variable variable JJ cord-005453-4057qib7 3474 2 degree degree NN cord-005453-4057qib7 3474 3 of of IN cord-005453-4057qib7 3474 4 iron iron NN cord-005453-4057qib7 3474 5 overload overload NN cord-005453-4057qib7 3474 6 was be VBD cord-005453-4057qib7 3474 7 demonstrated demonstrate VBN cord-005453-4057qib7 3474 8 in in IN cord-005453-4057qib7 3474 9 all all DT cord-005453-4057qib7 3474 10 patient patient JJ cord-005453-4057qib7 3474 11 ( ( -LRB- cord-005453-4057qib7 3474 12 LIC LIC NNP cord-005453-4057qib7 3474 13 : : : cord-005453-4057qib7 3474 14 230 230 CD cord-005453-4057qib7 3474 15 - - HYPH cord-005453-4057qib7 3474 16 340±50 340±50 CD cord-005453-4057qib7 3474 17 microg microg NNP cord-005453-4057qib7 3474 18 / / SYM cord-005453-4057qib7 3474 19 g g NN cord-005453-4057qib7 3474 20 ; ; : cord-005453-4057qib7 3474 21 baseline baseline JJ cord-005453-4057qib7 3474 22 serum serum NN cord-005453-4057qib7 3474 23 ferritin ferritin NN cord-005453-4057qib7 3474 24 : : : cord-005453-4057qib7 3474 25 685 685 CD cord-005453-4057qib7 3474 26 - - HYPH cord-005453-4057qib7 3474 27 3189 3189 CD cord-005453-4057qib7 3474 28 ng ng NNP cord-005453-4057qib7 3474 29 / / SYM cord-005453-4057qib7 3474 30 mL mL NNP cord-005453-4057qib7 3474 31 ) ) -RRB- cord-005453-4057qib7 3474 32 . . . cord-005453-4057qib7 3475 1 The the DT cord-005453-4057qib7 3475 2 potential potential JJ cord-005453-4057qib7 3475 3 risk risk NN cord-005453-4057qib7 3475 4 factors factor NNS cord-005453-4057qib7 3475 5 for for IN cord-005453-4057qib7 3475 6 FNH FNH NNP cord-005453-4057qib7 3475 7 are be VBP cord-005453-4057qib7 3475 8 reported report VBN cord-005453-4057qib7 3475 9 in in IN cord-005453-4057qib7 3475 10 table table NN cord-005453-4057qib7 3475 11 1 1 CD cord-005453-4057qib7 3475 12 . . . cord-005453-4057qib7 3476 1 In in IN cord-005453-4057qib7 3476 2 8/11 8/11 CD cord-005453-4057qib7 3476 3 patients patient NNS cord-005453-4057qib7 3476 4 , , , cord-005453-4057qib7 3476 5 the the DT cord-005453-4057qib7 3476 6 radiological radiological JJ cord-005453-4057qib7 3476 7 finding finding NN cord-005453-4057qib7 3476 8 was be VBD cord-005453-4057qib7 3476 9 pathognomonic pathognomonic JJ cord-005453-4057qib7 3476 10 ; ; : cord-005453-4057qib7 3476 11 in in IN cord-005453-4057qib7 3476 12 1/11 1/11 CD cord-005453-4057qib7 3476 13 the the DT cord-005453-4057qib7 3476 14 diagnosis diagnosis NN cord-005453-4057qib7 3476 15 of of IN cord-005453-4057qib7 3476 16 FNH FNH NNP cord-005453-4057qib7 3476 17 was be VBD cord-005453-4057qib7 3476 18 confirmed confirm VBN cord-005453-4057qib7 3476 19 histologically histologically RB cord-005453-4057qib7 3476 20 , , , cord-005453-4057qib7 3476 21 while while IN cord-005453-4057qib7 3476 22 2/11 2/11 CD cord-005453-4057qib7 3476 23 subjects subject NNS cord-005453-4057qib7 3476 24 were be VBD cord-005453-4057qib7 3476 25 labelled label VBN cord-005453-4057qib7 3476 26 as as IN cord-005453-4057qib7 3476 27 " " `` cord-005453-4057qib7 3476 28 FNHlike fnhlike JJ cord-005453-4057qib7 3476 29 " " '' cord-005453-4057qib7 3476 30 , , , cord-005453-4057qib7 3476 31 although although IN cord-005453-4057qib7 3476 32 a a DT cord-005453-4057qib7 3476 33 potential potential JJ cord-005453-4057qib7 3476 34 diagnosis diagnosis NN cord-005453-4057qib7 3476 35 of of IN cord-005453-4057qib7 3476 36 hepatic hepatic JJ cord-005453-4057qib7 3476 37 adenoma adenoma NN cord-005453-4057qib7 3476 38 could could MD cord-005453-4057qib7 3476 39 not not RB cord-005453-4057qib7 3476 40 be be VB cord-005453-4057qib7 3476 41 ruled rule VBN cord-005453-4057qib7 3476 42 out out RP cord-005453-4057qib7 3476 43 . . . cord-005453-4057qib7 3477 1 In in IN cord-005453-4057qib7 3477 2 3/11 3/11 CD cord-005453-4057qib7 3477 3 patients patient NNS cord-005453-4057qib7 3477 4 , , , cord-005453-4057qib7 3477 5 FNH FNH NNP cord-005453-4057qib7 3477 6 presented present VBD cord-005453-4057qib7 3477 7 with with IN cord-005453-4057qib7 3477 8 an an DT cord-005453-4057qib7 3477 9 isolated isolated JJ cord-005453-4057qib7 3477 10 lesion lesion NN cord-005453-4057qib7 3477 11 , , , cord-005453-4057qib7 3477 12 while while IN cord-005453-4057qib7 3477 13 8/11 8/11 CD cord-005453-4057qib7 3477 14 had have VBD cord-005453-4057qib7 3477 15 2 2 CD cord-005453-4057qib7 3477 16 to to IN cord-005453-4057qib7 3477 17 more more JJR cord-005453-4057qib7 3477 18 than than IN cord-005453-4057qib7 3477 19 10 10 CD cord-005453-4057qib7 3477 20 hepatic hepatic JJ cord-005453-4057qib7 3477 21 nodules nodule NNS cord-005453-4057qib7 3477 22 at at IN cord-005453-4057qib7 3477 23 diagnosis diagnosis NN cord-005453-4057qib7 3477 24 . . . cord-005453-4057qib7 3478 1 The the DT cord-005453-4057qib7 3478 2 size size NN cord-005453-4057qib7 3478 3 of of IN cord-005453-4057qib7 3478 4 nodules nodule NNS cord-005453-4057qib7 3478 5 at at IN cord-005453-4057qib7 3478 6 diagnosis diagnosis NN cord-005453-4057qib7 3478 7 ranged range VBD cord-005453-4057qib7 3478 8 from from IN cord-005453-4057qib7 3478 9 3 3 CD cord-005453-4057qib7 3478 10 to to IN cord-005453-4057qib7 3478 11 41 41 CD cord-005453-4057qib7 3478 12 mm mm NNS cord-005453-4057qib7 3478 13 . . . cord-005453-4057qib7 3479 1 In in IN cord-005453-4057qib7 3479 2 unenhanced unenhanced JJ cord-005453-4057qib7 3479 3 MRI MRI NNP cord-005453-4057qib7 3479 4 scans scan NNS cord-005453-4057qib7 3479 5 , , , cord-005453-4057qib7 3479 6 lesions lesion NNS cord-005453-4057qib7 3479 7 were be VBD cord-005453-4057qib7 3479 8 predominantly predominantly RB cord-005453-4057qib7 3479 9 hyperintense hyperintense NN cord-005453-4057qib7 3479 10 on on IN cord-005453-4057qib7 3479 11 both both CC cord-005453-4057qib7 3479 12 T1-and t1-and XX cord-005453-4057qib7 3479 13 T2weighted t2weighted JJ cord-005453-4057qib7 3479 14 sequences sequence NNS cord-005453-4057qib7 3479 15 . . . cord-005453-4057qib7 3480 1 In in IN cord-005453-4057qib7 3480 2 dynamic dynamic JJ cord-005453-4057qib7 3480 3 studies study NNS cord-005453-4057qib7 3480 4 with with IN cord-005453-4057qib7 3480 5 contrast contrast NN cord-005453-4057qib7 3480 6 medium medium NN cord-005453-4057qib7 3480 7 , , , cord-005453-4057qib7 3480 8 all all DT cord-005453-4057qib7 3480 9 lesions lesion NNS cord-005453-4057qib7 3480 10 strongly strongly RB cord-005453-4057qib7 3480 11 enhanced enhance VBD cord-005453-4057qib7 3480 12 during during IN cord-005453-4057qib7 3480 13 the the DT cord-005453-4057qib7 3480 14 arterial arterial JJ cord-005453-4057qib7 3480 15 phase phase NN cord-005453-4057qib7 3480 16 , , , cord-005453-4057qib7 3480 17 with with IN cord-005453-4057qib7 3480 18 a a DT cord-005453-4057qib7 3480 19 variable variable JJ cord-005453-4057qib7 3480 20 degree degree NN cord-005453-4057qib7 3480 21 of of IN cord-005453-4057qib7 3480 22 wash wash NN cord-005453-4057qib7 3480 23 - - HYPH cord-005453-4057qib7 3480 24 out out NN cord-005453-4057qib7 3480 25 in in IN cord-005453-4057qib7 3480 26 the the DT cord-005453-4057qib7 3480 27 late late JJ cord-005453-4057qib7 3480 28 venous venous JJ cord-005453-4057qib7 3480 29 scans scan NNS cord-005453-4057qib7 3480 30 . . . cord-005453-4057qib7 3481 1 Hepatic hepatic JJ cord-005453-4057qib7 3481 2 function function NN cord-005453-4057qib7 3481 3 tests test NNS cord-005453-4057qib7 3481 4 were be VBD cord-005453-4057qib7 3481 5 normal normal JJ cord-005453-4057qib7 3481 6 in in IN cord-005453-4057qib7 3481 7 all all PDT cord-005453-4057qib7 3481 8 the the DT cord-005453-4057qib7 3481 9 enrolled enrol VBN cord-005453-4057qib7 3481 10 patients patient NNS cord-005453-4057qib7 3481 11 at at IN cord-005453-4057qib7 3481 12 diagnosis diagnosis NN cord-005453-4057qib7 3481 13 of of IN cord-005453-4057qib7 3481 14 FNH FNH NNP cord-005453-4057qib7 3481 15 . . . cord-005453-4057qib7 3482 1 Among among IN cord-005453-4057qib7 3482 2 the the DT cord-005453-4057qib7 3482 3 9/11 9/11 CD cord-005453-4057qib7 3482 4 patients patient NNS cord-005453-4057qib7 3482 5 for for IN cord-005453-4057qib7 3482 6 whom whom WP cord-005453-4057qib7 3482 7 at at IN cord-005453-4057qib7 3482 8 least least JJS cord-005453-4057qib7 3482 9 a a DT cord-005453-4057qib7 3482 10 follow follow NN cord-005453-4057qib7 3482 11 - - HYPH cord-005453-4057qib7 3482 12 up up NN cord-005453-4057qib7 3482 13 scan scan NN cord-005453-4057qib7 3482 14 was be VBD cord-005453-4057qib7 3482 15 available available JJ cord-005453-4057qib7 3482 16 , , , cord-005453-4057qib7 3482 17 1 1 CD cord-005453-4057qib7 3482 18 presented present VBD cord-005453-4057qib7 3482 19 a a DT cord-005453-4057qib7 3482 20 complete complete JJ cord-005453-4057qib7 3482 21 regression regression NN cord-005453-4057qib7 3482 22 , , , cord-005453-4057qib7 3482 23 3 3 CD cord-005453-4057qib7 3482 24 a a DT cord-005453-4057qib7 3482 25 reduction reduction NN cord-005453-4057qib7 3482 26 and and CC cord-005453-4057qib7 3482 27 3 3 CD cord-005453-4057qib7 3482 28 an an DT cord-005453-4057qib7 3482 29 increase increase NN cord-005453-4057qib7 3482 30 in in IN cord-005453-4057qib7 3482 31 the the DT cord-005453-4057qib7 3482 32 size size NN cord-005453-4057qib7 3482 33 and/or and/or CC cord-005453-4057qib7 3482 34 number number NN cord-005453-4057qib7 3482 35 of of IN cord-005453-4057qib7 3482 36 lesions lesion NNS cord-005453-4057qib7 3482 37 , , , cord-005453-4057qib7 3482 38 while while IN cord-005453-4057qib7 3482 39 in in IN cord-005453-4057qib7 3482 40 2 2 CD cord-005453-4057qib7 3482 41 patients patient NNS cord-005453-4057qib7 3482 42 the the DT cord-005453-4057qib7 3482 43 nodules nodule NNS cord-005453-4057qib7 3482 44 remained remain VBD cord-005453-4057qib7 3482 45 substantially substantially RB cord-005453-4057qib7 3482 46 unchanged unchanged JJ cord-005453-4057qib7 3482 47 after after IN cord-005453-4057qib7 3482 48 a a DT cord-005453-4057qib7 3482 49 mean mean JJ cord-005453-4057qib7 3482 50 radiological radiological JJ cord-005453-4057qib7 3482 51 follow follow NN cord-005453-4057qib7 3482 52 - - HYPH cord-005453-4057qib7 3482 53 up up NN cord-005453-4057qib7 3482 54 of of IN cord-005453-4057qib7 3482 55 4.5±3.3 4.5±3.3 CD cord-005453-4057qib7 3482 56 years year NNS cord-005453-4057qib7 3482 57 . . . cord-005453-4057qib7 3483 1 No no DT cord-005453-4057qib7 3483 2 malignant malignant JJ cord-005453-4057qib7 3483 3 transformations transformation NNS cord-005453-4057qib7 3483 4 were be VBD cord-005453-4057qib7 3483 5 observed observe VBN cord-005453-4057qib7 3483 6 . . . cord-005453-4057qib7 3484 1 Conclusions conclusion NNS cord-005453-4057qib7 3484 2 : : : cord-005453-4057qib7 3485 1 FNH FNH NNP cord-005453-4057qib7 3485 2 represents represent VBZ cord-005453-4057qib7 3485 3 a a DT cord-005453-4057qib7 3485 4 relatively relatively RB cord-005453-4057qib7 3485 5 frequent frequent JJ cord-005453-4057qib7 3485 6 incidental incidental JJ cord-005453-4057qib7 3485 7 finding finding NN cord-005453-4057qib7 3485 8 after after IN cord-005453-4057qib7 3485 9 HSCT HSCT NNP cord-005453-4057qib7 3485 10 . . . cord-005453-4057qib7 3486 1 Although although IN cord-005453-4057qib7 3486 2 a a DT cord-005453-4057qib7 3486 3 malignant malignant JJ cord-005453-4057qib7 3486 4 transformation transformation NN cord-005453-4057qib7 3486 5 is be VBZ cord-005453-4057qib7 3486 6 rare rare JJ cord-005453-4057qib7 3486 7 , , , cord-005453-4057qib7 3486 8 given give VBN cord-005453-4057qib7 3486 9 the the DT cord-005453-4057qib7 3486 10 demonstrated demonstrate VBN cord-005453-4057qib7 3486 11 variable variable JJ cord-005453-4057qib7 3486 12 evolution evolution NN cord-005453-4057qib7 3486 13 of of IN cord-005453-4057qib7 3486 14 the the DT cord-005453-4057qib7 3486 15 hepatic hepatic JJ cord-005453-4057qib7 3486 16 nodules nodule NNS cord-005453-4057qib7 3486 17 , , , cord-005453-4057qib7 3486 18 a a DT cord-005453-4057qib7 3486 19 radiological radiological JJ cord-005453-4057qib7 3486 20 follow follow NN cord-005453-4057qib7 3486 21 - - HYPH cord-005453-4057qib7 3486 22 up up NN cord-005453-4057qib7 3486 23 is be VBZ cord-005453-4057qib7 3486 24 highly highly RB cord-005453-4057qib7 3486 25 recommended recommend VBN cord-005453-4057qib7 3486 26 . . . cord-005453-4057qib7 3487 1 Disclosure disclosure NN cord-005453-4057qib7 3487 2 : : : cord-005453-4057qib7 3487 3 Nothing nothing NN cord-005453-4057qib7 3487 4 to to TO cord-005453-4057qib7 3487 5 disclose disclose VB cord-005453-4057qib7 3487 6 . . . cord-005453-4057qib7 3488 1 Incidence incidence NN cord-005453-4057qib7 3488 2 and and CC cord-005453-4057qib7 3488 3 risk risk NN cord-005453-4057qib7 3488 4 factors factor NNS cord-005453-4057qib7 3488 5 for for IN cord-005453-4057qib7 3488 6 hepatic hepatic JJ cord-005453-4057qib7 3488 7 sinusoidal sinusoidal JJ cord-005453-4057qib7 3488 8 obstruction obstruction NN cord-005453-4057qib7 3488 9 syndrome syndrome NN cord-005453-4057qib7 3488 10 after after IN cord-005453-4057qib7 3488 11 allogeneic allogeneic NN cord-005453-4057qib7 3488 12 transplantation transplantation NN cord-005453-4057qib7 3488 13 : : : cord-005453-4057qib7 3488 14 Retrospective retrospective JJ cord-005453-4057qib7 3488 15 multicenter multicenter JJ cord-005453-4057qib7 3488 16 study study NN cord-005453-4057qib7 3488 17 of of IN cord-005453-4057qib7 3488 18 Turkish turkish JJ cord-005453-4057qib7 3488 19 hematology hematology NN cord-005453-4057qib7 3488 20 research research NN cord-005453-4057qib7 3488 21 and and CC cord-005453-4057qib7 3488 22 education education NN cord-005453-4057qib7 3488 23 group group NN cord-005453-4057qib7 3488 24 ( ( -LRB- cord-005453-4057qib7 3488 25 THREG THREG NNP cord-005453-4057qib7 3488 26 ) ) -RRB- cord-005453-4057qib7 3488 27 , , , cord-005453-4057qib7 3488 28 updated update VBN cord-005453-4057qib7 3488 29 data datum NNS cord-005453-4057qib7 3488 30 Methods method NNS cord-005453-4057qib7 3488 31 : : : cord-005453-4057qib7 3488 32 Ten ten CD cord-005453-4057qib7 3488 33 centers center NNS cord-005453-4057qib7 3488 34 from from IN cord-005453-4057qib7 3488 35 Turkey Turkey NNP cord-005453-4057qib7 3488 36 were be VBD cord-005453-4057qib7 3488 37 enrolled enrol VBN cord-005453-4057qib7 3488 38 in in IN cord-005453-4057qib7 3488 39 the the DT cord-005453-4057qib7 3488 40 study study NN cord-005453-4057qib7 3488 41 . . . cord-005453-4057qib7 3489 1 We -PRON- PRP cord-005453-4057qib7 3489 2 retrospectively retrospectively RB cord-005453-4057qib7 3489 3 evaluated evaluate VBD cord-005453-4057qib7 3489 4 the the DT cord-005453-4057qib7 3489 5 medical medical JJ cord-005453-4057qib7 3489 6 records record NNS cord-005453-4057qib7 3489 7 of of IN cord-005453-4057qib7 3489 8 patients patient NNS cord-005453-4057qib7 3489 9 who who WP cord-005453-4057qib7 3489 10 were be VBD cord-005453-4057qib7 3489 11 treated treat VBN cord-005453-4057qib7 3489 12 with with IN cord-005453-4057qib7 3489 13 allo allo NNP cord-005453-4057qib7 3489 14 - - HYPH cord-005453-4057qib7 3489 15 SCT SCT NNP cord-005453-4057qib7 3489 16 between between IN cord-005453-4057qib7 3489 17 January January NNP cord-005453-4057qib7 3489 18 2012 2012 CD cord-005453-4057qib7 3489 19 and and CC cord-005453-4057qib7 3489 20 December December NNP cord-005453-4057qib7 3489 21 2015 2015 CD cord-005453-4057qib7 3489 22 . . . cord-005453-4057qib7 3490 1 A a DT cord-005453-4057qib7 3490 2 Baltimore Baltimore NNP cord-005453-4057qib7 3490 3 criterion criterion NN cord-005453-4057qib7 3490 4 was be VBD cord-005453-4057qib7 3490 5 used use VBN cord-005453-4057qib7 3490 6 for for IN cord-005453-4057qib7 3490 7 assessment assessment NN cord-005453-4057qib7 3490 8 of of IN cord-005453-4057qib7 3490 9 HSOS HSOS NNP cord-005453-4057qib7 3490 10 . . . cord-005453-4057qib7 3491 1 Four four CD cord-005453-4057qib7 3491 2 hundred hundred CD cord-005453-4057qib7 3491 3 twenty twenty CD cord-005453-4057qib7 3491 4 six six CD cord-005453-4057qib7 3491 5 ( ( -LRB- cord-005453-4057qib7 3491 6 97.2 97.2 CD cord-005453-4057qib7 3491 7 % % NN cord-005453-4057qib7 3491 8 ) ) -RRB- cord-005453-4057qib7 3491 9 of of IN cord-005453-4057qib7 3491 10 438 438 CD cord-005453-4057qib7 3491 11 patients patient NNS cord-005453-4057qib7 3491 12 who who WP cord-005453-4057qib7 3491 13 were be VBD cord-005453-4057qib7 3491 14 treated treat VBN cord-005453-4057qib7 3491 15 with with IN cord-005453-4057qib7 3491 16 prophylaxis prophylaxis NN cord-005453-4057qib7 3491 17 with with IN cord-005453-4057qib7 3491 18 defibrotide defibrotide NN cord-005453-4057qib7 3491 19 alone alone JJ cord-005453-4057qib7 3491 20 or or CC cord-005453-4057qib7 3491 21 one one CD cord-005453-4057qib7 3491 22 or or CC cord-005453-4057qib7 3491 23 more more JJR cord-005453-4057qib7 3491 24 of of IN cord-005453-4057qib7 3491 25 the the DT cord-005453-4057qib7 3491 26 N N NNP cord-005453-4057qib7 3491 27 - - HYPH cord-005453-4057qib7 3491 28 Acetylcysteine Acetylcysteine NNP cord-005453-4057qib7 3491 29 , , , cord-005453-4057qib7 3491 30 diuretics diuretic NNS cord-005453-4057qib7 3491 31 and and CC cord-005453-4057qib7 3491 32 heparin heparin NN cord-005453-4057qib7 3491 33 used use VBD cord-005453-4057qib7 3491 34 defibrotide defibrotide NNP cord-005453-4057qib7 3491 35 ( ( -LRB- cord-005453-4057qib7 3491 36 10 10 CD cord-005453-4057qib7 3491 37 - - SYM cord-005453-4057qib7 3491 38 25 25 CD cord-005453-4057qib7 3491 39 mg mg NNP cord-005453-4057qib7 3491 40 / / SYM cord-005453-4057qib7 3491 41 kg kg NNP cord-005453-4057qib7 3491 42 / / SYM cord-005453-4057qib7 3491 43 day day NN cord-005453-4057qib7 3491 44 ) ) -RRB- cord-005453-4057qib7 3491 45 . . . cord-005453-4057qib7 3492 1 Results result NNS cord-005453-4057qib7 3492 2 : : : cord-005453-4057qib7 3493 1 The the DT cord-005453-4057qib7 3493 2 study study NN cord-005453-4057qib7 3493 3 included include VBD cord-005453-4057qib7 3493 4 1153 1153 CD cord-005453-4057qib7 3493 5 patients patient NNS cord-005453-4057qib7 3493 6 ( ( -LRB- cord-005453-4057qib7 3493 7 687 687 CD cord-005453-4057qib7 3493 8 males/ males/ CD cord-005453-4057qib7 3493 9 466 466 CD cord-005453-4057qib7 3493 10 females female NNS cord-005453-4057qib7 3493 11 ) ) -RRB- cord-005453-4057qib7 3493 12 with with IN cord-005453-4057qib7 3493 13 median median JJ cord-005453-4057qib7 3493 14 age age NN cord-005453-4057qib7 3493 15 of of IN cord-005453-4057qib7 3493 16 38 38 CD cord-005453-4057qib7 3493 17 ( ( -LRB- cord-005453-4057qib7 3493 18 15 15 CD cord-005453-4057qib7 3493 19 - - SYM cord-005453-4057qib7 3493 20 71 71 CD cord-005453-4057qib7 3493 21 ) ) -RRB- cord-005453-4057qib7 3493 22 years year NNS cord-005453-4057qib7 3493 23 . . . cord-005453-4057qib7 3494 1 The the DT cord-005453-4057qib7 3494 2 demographic demographic JJ cord-005453-4057qib7 3494 3 and and CC cord-005453-4057qib7 3494 4 clinical clinical JJ cord-005453-4057qib7 3494 5 characteristics characteristic NNS cord-005453-4057qib7 3494 6 of of IN cord-005453-4057qib7 3494 7 patients patient NNS cord-005453-4057qib7 3494 8 were be VBD cord-005453-4057qib7 3494 9 summarized summarize VBN cord-005453-4057qib7 3494 10 in in IN cord-005453-4057qib7 3494 11 Table Table NNP cord-005453-4057qib7 3494 12 1 1 CD cord-005453-4057qib7 3494 13 Seventy seventy CD cord-005453-4057qib7 3494 14 - - HYPH cord-005453-4057qib7 3494 15 three three CD cord-005453-4057qib7 3494 16 ( ( -LRB- cord-005453-4057qib7 3494 17 84.9 84.9 CD cord-005453-4057qib7 3494 18 % % NN cord-005453-4057qib7 3494 19 ) ) -RRB- cord-005453-4057qib7 3494 20 of of IN cord-005453-4057qib7 3494 21 patients patient NNS cord-005453-4057qib7 3494 22 with with IN cord-005453-4057qib7 3494 23 HSOS HSOS NNP cord-005453-4057qib7 3494 24 were be VBD cord-005453-4057qib7 3494 25 treated treat VBN cord-005453-4057qib7 3494 26 with with IN cord-005453-4057qib7 3494 27 defibrotide defibrotide NN cord-005453-4057qib7 3494 28 after after IN cord-005453-4057qib7 3494 29 diagnosis diagnosis NN cord-005453-4057qib7 3494 30 . . . cord-005453-4057qib7 3495 1 The the DT cord-005453-4057qib7 3495 2 median median JJ cord-005453-4057qib7 3495 3 time time NN cord-005453-4057qib7 3495 4 of of IN cord-005453-4057qib7 3495 5 starting start VBG cord-005453-4057qib7 3495 6 defibrotide defibrotide NN cord-005453-4057qib7 3495 7 in in IN cord-005453-4057qib7 3495 8 these these DT cord-005453-4057qib7 3495 9 patients patient NNS cord-005453-4057qib7 3495 10 was be VBD cord-005453-4057qib7 3495 11 13.5 13.5 CD cord-005453-4057qib7 3495 12 ( ( -LRB- cord-005453-4057qib7 3495 13 2 2 CD cord-005453-4057qib7 3495 14 - - SYM cord-005453-4057qib7 3495 15 29 29 CD cord-005453-4057qib7 3495 16 ) ) -RRB- cord-005453-4057qib7 3495 17 days day NNS cord-005453-4057qib7 3495 18 . . . cord-005453-4057qib7 3496 1 Thirty thirty CD cord-005453-4057qib7 3496 2 - - HYPH cord-005453-4057qib7 3496 3 seven seven CD cord-005453-4057qib7 3496 4 ( ( -LRB- cord-005453-4057qib7 3496 5 43 43 CD cord-005453-4057qib7 3496 6 % % NN cord-005453-4057qib7 3496 7 ) ) -RRB- cord-005453-4057qib7 3496 8 of of IN cord-005453-4057qib7 3496 9 patients patient NNS cord-005453-4057qib7 3496 10 with with IN cord-005453-4057qib7 3496 11 HSOS HSOS NNP cord-005453-4057qib7 3496 12 recovered recover VBD cord-005453-4057qib7 3496 13 completely completely RB cord-005453-4057qib7 3496 14 and and CC cord-005453-4057qib7 3496 15 forty forty CD cord-005453-4057qib7 3496 16 - - HYPH cord-005453-4057qib7 3496 17 nine nine CD cord-005453-4057qib7 3496 18 ( ( -LRB- cord-005453-4057qib7 3496 19 57 57 CD cord-005453-4057qib7 3496 20 % % NN cord-005453-4057qib7 3496 21 ) ) -RRB- cord-005453-4057qib7 3496 22 of of IN cord-005453-4057qib7 3496 23 them -PRON- PRP cord-005453-4057qib7 3496 24 died die VBD cord-005453-4057qib7 3496 25 as as IN cord-005453-4057qib7 3496 26 a a DT cord-005453-4057qib7 3496 27 result result NN cord-005453-4057qib7 3496 28 of of IN cord-005453-4057qib7 3496 29 multi multi JJ cord-005453-4057qib7 3496 30 organ organ NN cord-005453-4057qib7 3496 31 failure failure NN cord-005453-4057qib7 3496 32 . . . cord-005453-4057qib7 3497 1 The the DT cord-005453-4057qib7 3497 2 incidence incidence NN cord-005453-4057qib7 3497 3 of of IN cord-005453-4057qib7 3497 4 HSOS HSOS NNP cord-005453-4057qib7 3497 5 - - HYPH cord-005453-4057qib7 3497 6 related relate VBN cord-005453-4057qib7 3497 7 mortality mortality NN cord-005453-4057qib7 3497 8 in in IN cord-005453-4057qib7 3497 9 allo allo NN cord-005453-4057qib7 3497 10 - - HYPH cord-005453-4057qib7 3497 11 HSCT HSCT NNP cord-005453-4057qib7 3497 12 cohort cohort NN cord-005453-4057qib7 3497 13 was be VBD cord-005453-4057qib7 3497 14 found find VBN cord-005453-4057qib7 3497 15 to to TO cord-005453-4057qib7 3497 16 be be VB cord-005453-4057qib7 3497 17 4.2 4.2 CD cord-005453-4057qib7 3497 18 % % NN cord-005453-4057qib7 3497 19 . . . cord-005453-4057qib7 3498 1 In in IN cord-005453-4057qib7 3498 2 univariate univariate JJ cord-005453-4057qib7 3498 3 analysis analysis NN cord-005453-4057qib7 3498 4 , , , cord-005453-4057qib7 3498 5 statistically statistically RB cord-005453-4057qib7 3498 6 significant significant JJ cord-005453-4057qib7 3498 7 associations association NNS cord-005453-4057qib7 3498 8 were be VBD cord-005453-4057qib7 3498 9 not not RB cord-005453-4057qib7 3498 10 found find VBN cord-005453-4057qib7 3498 11 between between IN cord-005453-4057qib7 3498 12 HSOS HSOS NNP cord-005453-4057qib7 3498 13 incidence incidence NN cord-005453-4057qib7 3498 14 and and CC cord-005453-4057qib7 3498 15 age age NN cord-005453-4057qib7 3498 16 / / SYM cord-005453-4057qib7 3498 17 sex sex NN cord-005453-4057qib7 3498 18 of of IN cord-005453-4057qib7 3498 19 recipient recipient NN cord-005453-4057qib7 3498 20 , , , cord-005453-4057qib7 3498 21 type type NN cord-005453-4057qib7 3498 22 of of IN cord-005453-4057qib7 3498 23 conditioning conditioning NN cord-005453-4057qib7 3498 24 regimen regimen NN cord-005453-4057qib7 3498 25 , , , cord-005453-4057qib7 3498 26 stem stem NN cord-005453-4057qib7 3498 27 cell cell NN cord-005453-4057qib7 3498 28 source source NN cord-005453-4057qib7 3498 29 and and CC cord-005453-4057qib7 3498 30 type type NN cord-005453-4057qib7 3498 31 of of IN cord-005453-4057qib7 3498 32 GVHD GVHD NNP cord-005453-4057qib7 3498 33 prophylaxis prophylaxis NN cord-005453-4057qib7 3498 34 . . . cord-005453-4057qib7 3499 1 On on IN cord-005453-4057qib7 3499 2 the the DT cord-005453-4057qib7 3499 3 other other JJ cord-005453-4057qib7 3499 4 hand hand NN cord-005453-4057qib7 3499 5 donor donor NN cord-005453-4057qib7 3499 6 type type NN cord-005453-4057qib7 3499 7 , , , cord-005453-4057qib7 3499 8 engraftment engraftment NN cord-005453-4057qib7 3499 9 status status NN cord-005453-4057qib7 3499 10 and and CC cord-005453-4057qib7 3499 11 prophylaxis prophylaxis NN cord-005453-4057qib7 3499 12 for for IN cord-005453-4057qib7 3499 13 HSOS HSOS NNP cord-005453-4057qib7 3499 14 were be VBD cord-005453-4057qib7 3499 15 significantly significantly RB cord-005453-4057qib7 3499 16 associated associate VBN cord-005453-4057qib7 3499 17 with with IN cord-005453-4057qib7 3499 18 HSOS HSOS NNP cord-005453-4057qib7 3499 19 development development NN cord-005453-4057qib7 3499 20 . . . cord-005453-4057qib7 3500 1 HSOS HSOS NNP cord-005453-4057qib7 3500 2 prophylaxis prophylaxis NN cord-005453-4057qib7 3500 3 was be VBD cord-005453-4057qib7 3500 4 significantly significantly RB cord-005453-4057qib7 3500 5 decreased decrease VBN cord-005453-4057qib7 3500 6 HSOS HSOS NNP cord-005453-4057qib7 3500 7 - - HYPH cord-005453-4057qib7 3500 8 associated associate VBN cord-005453-4057qib7 3500 9 mortality mortality NN cord-005453-4057qib7 3500 10 ( ( -LRB- cord-005453-4057qib7 3500 11 p=0.001 p=0.001 NNP cord-005453-4057qib7 3500 12 ) ) -RRB- cord-005453-4057qib7 3500 13 . . . cord-005453-4057qib7 3501 1 Conclusions conclusion NNS cord-005453-4057qib7 3501 2 : : : cord-005453-4057qib7 3502 1 HSOS HSOS NNP cord-005453-4057qib7 3502 2 still still RB cord-005453-4057qib7 3502 3 remains remain VBZ cord-005453-4057qib7 3502 4 a a DT cord-005453-4057qib7 3502 5 serious serious JJ cord-005453-4057qib7 3502 6 lifethreatening lifethreatening JJ cord-005453-4057qib7 3502 7 complication complication NN cord-005453-4057qib7 3502 8 of of IN cord-005453-4057qib7 3502 9 allo allo NN cord-005453-4057qib7 3502 10 - - HYPH cord-005453-4057qib7 3502 11 SCT SCT NNP cord-005453-4057qib7 3502 12 . . . cord-005453-4057qib7 3503 1 Although although IN cord-005453-4057qib7 3503 2 the the DT cord-005453-4057qib7 3503 3 incidence incidence NN cord-005453-4057qib7 3503 4 is be VBZ cord-005453-4057qib7 3503 5 low low JJ cord-005453-4057qib7 3503 6 , , , cord-005453-4057qib7 3503 7 HSOS HSOS NNP cord-005453-4057qib7 3503 8 is be VBZ cord-005453-4057qib7 3503 9 associated associate VBN cord-005453-4057qib7 3503 10 with with IN cord-005453-4057qib7 3503 11 increased increase VBN cord-005453-4057qib7 3503 12 100-day 100-day JJ cord-005453-4057qib7 3503 13 non non JJ cord-005453-4057qib7 3503 14 - - JJ cord-005453-4057qib7 3503 15 relapse relapse JJ cord-005453-4057qib7 3503 16 mortality mortality NN cord-005453-4057qib7 3503 17 . . . cord-005453-4057qib7 3504 1 HSOS HSOS NNP cord-005453-4057qib7 3504 2 prophylaxis prophylaxis NN cord-005453-4057qib7 3504 3 especially especially RB cord-005453-4057qib7 3504 4 with with IN cord-005453-4057qib7 3504 5 defibrotide defibrotide NN cord-005453-4057qib7 3504 6 , , , cord-005453-4057qib7 3504 7 seems seem VBZ cord-005453-4057qib7 3504 8 to to TO cord-005453-4057qib7 3504 9 reduce reduce VB cord-005453-4057qib7 3504 10 HSOS HSOS NNP cord-005453-4057qib7 3504 11 associated associate VBN cord-005453-4057qib7 3504 12 mortality mortality NN cord-005453-4057qib7 3504 13 in in IN cord-005453-4057qib7 3504 14 high high JJ cord-005453-4057qib7 3504 15 risk risk NN cord-005453-4057qib7 3504 16 patients patient NNS cord-005453-4057qib7 3504 17 . . . cord-005453-4057qib7 3505 1 Disclosure disclosure NN cord-005453-4057qib7 3505 2 : : : cord-005453-4057qib7 3505 3 Nothing nothing NN cord-005453-4057qib7 3505 4 to to TO cord-005453-4057qib7 3505 5 declare declare VB cord-005453-4057qib7 3505 6 Prophylaxis Prophylaxis NNP cord-005453-4057qib7 3505 7 with with IN cord-005453-4057qib7 3505 8 defibrotide defibrotide NN cord-005453-4057qib7 3505 9 in in IN cord-005453-4057qib7 3505 10 adults adult NNS cord-005453-4057qib7 3505 11 at at IN cord-005453-4057qib7 3505 12 very very RB cord-005453-4057qib7 3505 13 high high JJ cord-005453-4057qib7 3505 14 risk risk NN cord-005453-4057qib7 3505 15 of of IN cord-005453-4057qib7 3505 16 veno veno NNP cord-005453-4057qib7 3505 17 - - HYPH cord-005453-4057qib7 3505 18 occlusive occlusive JJ cord-005453-4057qib7 3505 19 disease disease NN cord-005453-4057qib7 3505 20 : : : cord-005453-4057qib7 3505 21 Results result NNS cord-005453-4057qib7 3505 22 in in IN cord-005453-4057qib7 3505 23 11 11 CD cord-005453-4057qib7 3505 24 patients patient NNS cord-005453-4057qib7 3506 1 Background background NN cord-005453-4057qib7 3506 2 : : : cord-005453-4057qib7 3507 1 Hepatic hepatic JJ cord-005453-4057qib7 3507 2 Sinusoidal Sinusoidal NNP cord-005453-4057qib7 3507 3 Obstruction obstruction NN cord-005453-4057qib7 3508 1 Syndrome/ Syndrome/ NNP cord-005453-4057qib7 3508 2 Veno Veno NNP cord-005453-4057qib7 3508 3 - - HYPH cord-005453-4057qib7 3508 4 Occlusive Occlusive NNP cord-005453-4057qib7 3508 5 Disease Disease NNP cord-005453-4057qib7 3509 1 ( ( -LRB- cord-005453-4057qib7 3509 2 SOS SOS NNP cord-005453-4057qib7 3509 3 / / SYM cord-005453-4057qib7 3509 4 VOD VOD NNP cord-005453-4057qib7 3509 5 ) ) -RRB- cord-005453-4057qib7 3509 6 is be VBZ cord-005453-4057qib7 3509 7 a a DT cord-005453-4057qib7 3509 8 life life NN cord-005453-4057qib7 3509 9 threatening threaten VBG cord-005453-4057qib7 3509 10 complication complication NN cord-005453-4057qib7 3509 11 that that WDT cord-005453-4057qib7 3509 12 can can MD cord-005453-4057qib7 3509 13 occur occur VB cord-005453-4057qib7 3509 14 after after IN cord-005453-4057qib7 3509 15 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 3509 16 Stem Stem NNP cord-005453-4057qib7 3509 17 Cell Cell NNP cord-005453-4057qib7 3509 18 Transplantation transplantation NN cord-005453-4057qib7 3509 19 ( ( -LRB- cord-005453-4057qib7 3509 20 HSCT HSCT NNP cord-005453-4057qib7 3509 21 ) ) -RRB- cord-005453-4057qib7 3509 22 . . . cord-005453-4057qib7 3510 1 Severe severe JJ cord-005453-4057qib7 3510 2 SOS SOS NNP cord-005453-4057qib7 3510 3 / / SYM cord-005453-4057qib7 3510 4 VOD VOD NNP cord-005453-4057qib7 3510 5 rapidly rapidly RB cord-005453-4057qib7 3510 6 evolves evolve VBZ cord-005453-4057qib7 3510 7 in in IN cord-005453-4057qib7 3510 8 Multiple Multiple NNP cord-005453-4057qib7 3510 9 Organ Organ NNP cord-005453-4057qib7 3510 10 Dysfunction Dysfunction NNP cord-005453-4057qib7 3510 11 Syndrome Syndrome NNP cord-005453-4057qib7 3510 12 ( ( -LRB- cord-005453-4057qib7 3510 13 MODS MODS NNP cord-005453-4057qib7 3510 14 ) ) -RRB- cord-005453-4057qib7 3510 15 , , , cord-005453-4057qib7 3510 16 associated associate VBN cord-005453-4057qib7 3510 17 with with IN cord-005453-4057qib7 3510 18 a a DT cord-005453-4057qib7 3510 19 mortality mortality NN cord-005453-4057qib7 3510 20 rate rate NN cord-005453-4057qib7 3510 21 exceding excede VBG cord-005453-4057qib7 3510 22 80 80 CD cord-005453-4057qib7 3510 23 % % NN cord-005453-4057qib7 3510 24 . . . cord-005453-4057qib7 3511 1 Precocity precocity NN cord-005453-4057qib7 3511 2 of of IN cord-005453-4057qib7 3511 3 defibrotide defibrotide NN cord-005453-4057qib7 3511 4 ( ( -LRB- cord-005453-4057qib7 3511 5 DF DF NNP cord-005453-4057qib7 3511 6 ) ) -RRB- cord-005453-4057qib7 3511 7 treatment treatment NN cord-005453-4057qib7 3511 8 is be VBZ cord-005453-4057qib7 3511 9 the the DT cord-005453-4057qib7 3511 10 leading leading JJ cord-005453-4057qib7 3511 11 factor factor NN cord-005453-4057qib7 3511 12 for for IN cord-005453-4057qib7 3511 13 efficacy efficacy NN cord-005453-4057qib7 3511 14 . . . cord-005453-4057qib7 3512 1 Prophylactic prophylactic JJ cord-005453-4057qib7 3512 2 use use NN cord-005453-4057qib7 3512 3 of of IN cord-005453-4057qib7 3512 4 DF DF NNP cord-005453-4057qib7 3512 5 is be VBZ cord-005453-4057qib7 3512 6 recommended recommend VBN cord-005453-4057qib7 3512 7 in in IN cord-005453-4057qib7 3512 8 children child NNS cord-005453-4057qib7 3512 9 , , , cord-005453-4057qib7 3512 10 but but CC cord-005453-4057qib7 3512 11 its -PRON- PRP$ cord-005453-4057qib7 3512 12 value value NN cord-005453-4057qib7 3512 13 has have VBZ cord-005453-4057qib7 3512 14 not not RB cord-005453-4057qib7 3512 15 been be VBN cord-005453-4057qib7 3512 16 validated validate VBN cord-005453-4057qib7 3512 17 in in IN cord-005453-4057qib7 3512 18 the the DT cord-005453-4057qib7 3512 19 adult adult NN cord-005453-4057qib7 3512 20 population population NN cord-005453-4057qib7 3512 21 , , , cord-005453-4057qib7 3512 22 although although IN cord-005453-4057qib7 3512 23 factors factor NNS cord-005453-4057qib7 3512 24 for for IN cord-005453-4057qib7 3512 25 individual individual JJ cord-005453-4057qib7 3512 26 risk risk NN cord-005453-4057qib7 3512 27 assessment assessment NN cord-005453-4057qib7 3512 28 for for IN cord-005453-4057qib7 3512 29 VOD VOD NNP cord-005453-4057qib7 3512 30 are be VBP cord-005453-4057qib7 3512 31 debated debate VBN cord-005453-4057qib7 3512 32 . . . cord-005453-4057qib7 3513 1 We -PRON- PRP cord-005453-4057qib7 3513 2 here here RB cord-005453-4057qib7 3513 3 present present VBP cord-005453-4057qib7 3513 4 a a DT cord-005453-4057qib7 3513 5 real real JJ cord-005453-4057qib7 3513 6 - - HYPH cord-005453-4057qib7 3513 7 world world NN cord-005453-4057qib7 3513 8 experience experience NN cord-005453-4057qib7 3513 9 of of IN cord-005453-4057qib7 3513 10 DF DF NNP cord-005453-4057qib7 3513 11 prophylaxis prophylaxis NN cord-005453-4057qib7 3513 12 in in IN cord-005453-4057qib7 3513 13 adult adult NN cord-005453-4057qib7 3513 14 patients patient NNS cord-005453-4057qib7 3513 15 at at IN cord-005453-4057qib7 3513 16 very very RB cord-005453-4057qib7 3513 17 high high JJ cord-005453-4057qib7 3513 18 risk risk NN cord-005453-4057qib7 3513 19 of of IN cord-005453-4057qib7 3513 20 SOS SOS NNP cord-005453-4057qib7 3513 21 / / SYM cord-005453-4057qib7 3513 22 VOD VOD NNP cord-005453-4057qib7 3513 23 receiving receive VBG cord-005453-4057qib7 3513 24 allogeneic allogeneic IN cord-005453-4057qib7 3513 25 HSCT HSCT NNP cord-005453-4057qib7 3513 26 . . . cord-005453-4057qib7 3514 1 Methods method NNS cord-005453-4057qib7 3514 2 : : : cord-005453-4057qib7 3515 1 From from IN cord-005453-4057qib7 3515 2 2016 2016 CD cord-005453-4057qib7 3515 3 to to IN cord-005453-4057qib7 3515 4 2018 2018 CD cord-005453-4057qib7 3515 5 we -PRON- PRP cord-005453-4057qib7 3515 6 treated treat VBN cord-005453-4057qib7 3515 7 with with IN cord-005453-4057qib7 3515 8 prophylactic prophylactic JJ cord-005453-4057qib7 3515 9 Defibrotide Defibrotide NNP cord-005453-4057qib7 3515 10 and and CC cord-005453-4057qib7 3515 11 Ursodeoxycholic Ursodeoxycholic NNP cord-005453-4057qib7 3515 12 Acid Acid NNP cord-005453-4057qib7 3515 13 ( ( -LRB- cord-005453-4057qib7 3515 14 UDCA UDCA NNP cord-005453-4057qib7 3515 15 ) ) -RRB- cord-005453-4057qib7 3516 1 11 11 CD cord-005453-4057qib7 3516 2 patients patient NNS cord-005453-4057qib7 3516 3 , , , cord-005453-4057qib7 3516 4 median median JJ cord-005453-4057qib7 3516 5 age age NN cord-005453-4057qib7 3516 6 30 30 CD cord-005453-4057qib7 3516 7 years year NNS cord-005453-4057qib7 3517 1 ( ( -LRB- cord-005453-4057qib7 3517 2 range range NNP cord-005453-4057qib7 3517 3 21 21 CD cord-005453-4057qib7 3517 4 - - SYM cord-005453-4057qib7 3517 5 59 59 CD cord-005453-4057qib7 3517 6 ) ) -RRB- cord-005453-4057qib7 3517 7 . . . cord-005453-4057qib7 3518 1 Nine nine CD cord-005453-4057qib7 3518 2 patients patient NNS cord-005453-4057qib7 3518 3 received receive VBD cord-005453-4057qib7 3518 4 allogeneic allogeneic IN cord-005453-4057qib7 3518 5 HSCT HSCT NNP cord-005453-4057qib7 3518 6 for for IN cord-005453-4057qib7 3518 7 acute acute JJ cord-005453-4057qib7 3518 8 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 3518 9 leukemia leukemia NN cord-005453-4057qib7 3518 10 ( ( -LRB- cord-005453-4057qib7 3518 11 8 8 CD cord-005453-4057qib7 3518 12 B b NN cord-005453-4057qib7 3518 13 - - : cord-005453-4057qib7 3518 14 ALL all DT cord-005453-4057qib7 3518 15 and and CC cord-005453-4057qib7 3518 16 1 1 CD cord-005453-4057qib7 3518 17 T t NN cord-005453-4057qib7 3518 18 - - HYPH cord-005453-4057qib7 3518 19 ALL ALL NNP cord-005453-4057qib7 3518 20 ) ) -RRB- cord-005453-4057qib7 3518 21 , , , cord-005453-4057qib7 3518 22 one one CD cord-005453-4057qib7 3518 23 patient patient NN cord-005453-4057qib7 3518 24 for for IN cord-005453-4057qib7 3518 25 Severe severe JJ cord-005453-4057qib7 3518 26 Aplastic Aplastic NNP cord-005453-4057qib7 3518 27 Anemia anemia NN cord-005453-4057qib7 3518 28 , , , cord-005453-4057qib7 3518 29 one one CD cord-005453-4057qib7 3518 30 patient patient NN cord-005453-4057qib7 3518 31 for for IN cord-005453-4057qib7 3518 32 Primary Primary NNP cord-005453-4057qib7 3518 33 Myelofibrosis Myelofibrosis NNP cord-005453-4057qib7 3518 34 . . . cord-005453-4057qib7 3519 1 They -PRON- PRP cord-005453-4057qib7 3519 2 were be VBD cord-005453-4057qib7 3519 3 all all RB cord-005453-4057qib7 3519 4 at at IN cord-005453-4057qib7 3519 5 high high JJ cord-005453-4057qib7 3519 6 risk risk NN cord-005453-4057qib7 3519 7 for for IN cord-005453-4057qib7 3519 8 SOS SOS NNP cord-005453-4057qib7 3519 9 / / SYM cord-005453-4057qib7 3519 10 VOD VOD NNP cord-005453-4057qib7 3519 11 because because IN cord-005453-4057qib7 3519 12 of of IN cord-005453-4057qib7 3519 13 previous previous JJ cord-005453-4057qib7 3519 14 hepatotoxicity hepatotoxicity NN cord-005453-4057qib7 3519 15 ( ( -LRB- cord-005453-4057qib7 3519 16 3 3 CD cord-005453-4057qib7 3519 17 patients patient NNS cord-005453-4057qib7 3519 18 ) ) -RRB- cord-005453-4057qib7 3519 19 , , , cord-005453-4057qib7 3519 20 previous previous JJ cord-005453-4057qib7 3519 21 HSCT HSCT NNP cord-005453-4057qib7 3519 22 ( ( -LRB- cord-005453-4057qib7 3519 23 6 6 CD cord-005453-4057qib7 3519 24 patients patient NNS cord-005453-4057qib7 3519 25 ) ) -RRB- cord-005453-4057qib7 3519 26 , , , cord-005453-4057qib7 3519 27 double double JJ cord-005453-4057qib7 3519 28 alkylating alkylating JJ cord-005453-4057qib7 3519 29 agent agent NN cord-005453-4057qib7 3519 30 ( ( -LRB- cord-005453-4057qib7 3519 31 5 5 CD cord-005453-4057qib7 3519 32 patients patient NNS cord-005453-4057qib7 3519 33 ) ) -RRB- cord-005453-4057qib7 3519 34 or or CC cord-005453-4057qib7 3519 35 previous previous JJ cord-005453-4057qib7 3519 36 treatment treatment NN cord-005453-4057qib7 3519 37 with with IN cord-005453-4057qib7 3519 38 Inotuzomab Inotuzomab NNP cord-005453-4057qib7 3519 39 Ozogamicin Ozogamicin NNP cord-005453-4057qib7 3519 40 ( ( -LRB- cord-005453-4057qib7 3519 41 IO IO NNP cord-005453-4057qib7 3519 42 ; ; : cord-005453-4057qib7 3519 43 7 7 CD cord-005453-4057qib7 3519 44 patients patient NNS cord-005453-4057qib7 3519 45 ) ) -RRB- cord-005453-4057qib7 3519 46 . . . cord-005453-4057qib7 3520 1 Of of IN cord-005453-4057qib7 3520 2 the the DT cord-005453-4057qib7 3520 3 7 7 CD cord-005453-4057qib7 3520 4 patients patient NNS cord-005453-4057qib7 3520 5 treated treat VBN cord-005453-4057qib7 3520 6 with with IN cord-005453-4057qib7 3520 7 IO IO NNP cord-005453-4057qib7 3520 8 , , , cord-005453-4057qib7 3520 9 6 6 CD cord-005453-4057qib7 3520 10 received receive VBD cord-005453-4057qib7 3520 11 2 2 CD cord-005453-4057qib7 3520 12 cycles cycle NNS cord-005453-4057qib7 3520 13 of of IN cord-005453-4057qib7 3520 14 IO IO NNP cord-005453-4057qib7 3520 15 , , , cord-005453-4057qib7 3520 16 and and CC cord-005453-4057qib7 3520 17 1 1 CD cord-005453-4057qib7 3520 18 received receive VBD cord-005453-4057qib7 3520 19 1 1 CD cord-005453-4057qib7 3520 20 cycle cycle NN cord-005453-4057qib7 3520 21 , , , cord-005453-4057qib7 3520 22 with with IN cord-005453-4057qib7 3520 23 the the DT cord-005453-4057qib7 3520 24 last last JJ cord-005453-4057qib7 3520 25 IO IO NNP cord-005453-4057qib7 3520 26 dose dose NN cord-005453-4057qib7 3520 27 administered administer VBD cord-005453-4057qib7 3520 28 a a DT cord-005453-4057qib7 3520 29 median median JJ cord-005453-4057qib7 3520 30 41.5 41.5 CD cord-005453-4057qib7 3520 31 days day NNS cord-005453-4057qib7 3520 32 before before IN cord-005453-4057qib7 3520 33 HSCT HSCT NNP cord-005453-4057qib7 3520 34 ( ( -LRB- cord-005453-4057qib7 3520 35 range range NNP cord-005453-4057qib7 3520 36 34 34 CD cord-005453-4057qib7 3520 37 - - SYM cord-005453-4057qib7 3520 38 61 61 CD cord-005453-4057qib7 3520 39 d d NN cord-005453-4057qib7 3520 40 ) ) -RRB- cord-005453-4057qib7 3520 41 . . . cord-005453-4057qib7 3521 1 Defibrotide Defibrotide NNP cord-005453-4057qib7 3521 2 was be VBD cord-005453-4057qib7 3521 3 administered administer VBN cord-005453-4057qib7 3521 4 in in IN cord-005453-4057qib7 3521 5 4 4 CD cord-005453-4057qib7 3521 6 daily daily JJ cord-005453-4057qib7 3521 7 doses dose NNS cord-005453-4057qib7 3521 8 for for IN cord-005453-4057qib7 3521 9 a a DT cord-005453-4057qib7 3521 10 total total JJ cord-005453-4057qib7 3521 11 dose dose NN cord-005453-4057qib7 3521 12 of of IN cord-005453-4057qib7 3521 13 25 25 CD cord-005453-4057qib7 3521 14 mg/ mg/ NN cord-005453-4057qib7 3521 15 kg kg NN cord-005453-4057qib7 3521 16 per per IN cord-005453-4057qib7 3521 17 day day NN cord-005453-4057qib7 3521 18 and and CC cord-005453-4057qib7 3521 19 UDCA UDCA NNP cord-005453-4057qib7 3521 20 at at IN cord-005453-4057qib7 3521 21 the the DT cord-005453-4057qib7 3521 22 dose dose NN cord-005453-4057qib7 3521 23 of of IN cord-005453-4057qib7 3521 24 300 300 CD cord-005453-4057qib7 3521 25 mg mg NN cord-005453-4057qib7 3521 26 twice twice RB cord-005453-4057qib7 3521 27 per per IN cord-005453-4057qib7 3521 28 day day NN cord-005453-4057qib7 3521 29 , , , cord-005453-4057qib7 3521 30 starting start VBG cord-005453-4057qib7 3521 31 from from IN cord-005453-4057qib7 3521 32 day day NN cord-005453-4057qib7 3521 33 -6 -6 JJ cord-005453-4057qib7 3521 34 prior prior JJ cord-005453-4057qib7 3521 35 transplant transplant NN cord-005453-4057qib7 3521 36 . . . cord-005453-4057qib7 3522 1 All all DT cord-005453-4057qib7 3522 2 patients patient NNS cord-005453-4057qib7 3522 3 received receive VBD cord-005453-4057qib7 3522 4 Treosulfan Treosulfan NNP cord-005453-4057qib7 3522 5 - - HYPH cord-005453-4057qib7 3522 6 Fludarabine Fludarabine NNP cord-005453-4057qib7 3522 7 based base VBN cord-005453-4057qib7 3522 8 conditioning conditioning NN cord-005453-4057qib7 3522 9 . . . cord-005453-4057qib7 3523 1 In in IN cord-005453-4057qib7 3523 2 5 5 CD cord-005453-4057qib7 3523 3 patients patient NNS cord-005453-4057qib7 3523 4 Thiotepa Thiotepa NNP cord-005453-4057qib7 3523 5 was be VBD cord-005453-4057qib7 3523 6 added add VBN cord-005453-4057qib7 3523 7 to to IN cord-005453-4057qib7 3523 8 the the DT cord-005453-4057qib7 3523 9 conditioning conditioning NN cord-005453-4057qib7 3523 10 and and CC cord-005453-4057qib7 3523 11 in in IN cord-005453-4057qib7 3523 12 2 2 CD cord-005453-4057qib7 3523 13 patients patient NNS cord-005453-4057qib7 3523 14 a a DT cord-005453-4057qib7 3523 15 low low JJ cord-005453-4057qib7 3523 16 dose dose NN cord-005453-4057qib7 3523 17 4Gy 4gy JJ cord-005453-4057qib7 3523 18 TBI TBI NNP cord-005453-4057qib7 3523 19 . . . cord-005453-4057qib7 3524 1 GvHD GvHD NNP cord-005453-4057qib7 3524 2 prophylaxis prophylaxis NN cord-005453-4057qib7 3524 3 included include VBD cord-005453-4057qib7 3524 4 posttransplant posttransplant NNP cord-005453-4057qib7 3524 5 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 3524 6 , , , cord-005453-4057qib7 3524 7 rapamycin rapamycin NN cord-005453-4057qib7 3524 8 and and CC cord-005453-4057qib7 3524 9 mycophenolate mycophenolate VBP cord-005453-4057qib7 3524 10 in in IN cord-005453-4057qib7 3524 11 all all DT cord-005453-4057qib7 3524 12 patients patient NNS cord-005453-4057qib7 3524 13 , , , cord-005453-4057qib7 3524 14 except except IN cord-005453-4057qib7 3524 15 one one CD cord-005453-4057qib7 3524 16 patient patient NN cord-005453-4057qib7 3524 17 with with IN cord-005453-4057qib7 3524 18 Aplastic Aplastic NNP cord-005453-4057qib7 3524 19 Anemia Anemia NNP cord-005453-4057qib7 3524 20 receiving receive VBG cord-005453-4057qib7 3524 21 ATG ATG NNP cord-005453-4057qib7 3524 22 , , , cord-005453-4057qib7 3524 23 rapamycin rapamycin NN cord-005453-4057qib7 3524 24 and and CC cord-005453-4057qib7 3524 25 mycophenolate mycophenolate NNP cord-005453-4057qib7 3524 26 . . . cord-005453-4057qib7 3525 1 Donor donor NN cord-005453-4057qib7 3525 2 source source NN cord-005453-4057qib7 3525 3 was be VBD cord-005453-4057qib7 3525 4 PBSC PBSC NNS cord-005453-4057qib7 3525 5 in in IN cord-005453-4057qib7 3525 6 all all DT cord-005453-4057qib7 3525 7 cases case NNS cord-005453-4057qib7 3525 8 . . . cord-005453-4057qib7 3526 1 Seven seven CD cord-005453-4057qib7 3526 2 patients patient NNS cord-005453-4057qib7 3526 3 received receive VBD cord-005453-4057qib7 3526 4 family family NN cord-005453-4057qib7 3526 5 haploidentical haploidentical JJ cord-005453-4057qib7 3526 6 ( ( -LRB- cord-005453-4057qib7 3526 7 MMRD MMRD NNP cord-005453-4057qib7 3526 8 ) ) -RRB- cord-005453-4057qib7 3526 9 transplant transplant NN cord-005453-4057qib7 3526 10 , , , cord-005453-4057qib7 3526 11 1 1 CD cord-005453-4057qib7 3526 12 patient patient NN cord-005453-4057qib7 3526 13 a a DT cord-005453-4057qib7 3526 14 MRD MRD NNP cord-005453-4057qib7 3526 15 transplant transplant NN cord-005453-4057qib7 3526 16 and and CC cord-005453-4057qib7 3526 17 3 3 CD cord-005453-4057qib7 3526 18 patients patient NNS cord-005453-4057qib7 3526 19 a a DT cord-005453-4057qib7 3526 20 MUD mud NN cord-005453-4057qib7 3526 21 transplant transplant NN cord-005453-4057qib7 3526 22 . . . cord-005453-4057qib7 3527 1 Results result NNS cord-005453-4057qib7 3527 2 : : : cord-005453-4057qib7 3528 1 The the DT cord-005453-4057qib7 3528 2 median median JJ cord-005453-4057qib7 3528 3 duration duration NN cord-005453-4057qib7 3528 4 of of IN cord-005453-4057qib7 3528 5 defibrotide defibrotide NN cord-005453-4057qib7 3528 6 therapy therapy NN cord-005453-4057qib7 3528 7 was be VBD cord-005453-4057qib7 3528 8 34 34 CD cord-005453-4057qib7 3528 9 days day NNS cord-005453-4057qib7 3529 1 ( ( -LRB- cord-005453-4057qib7 3529 2 range range NNP cord-005453-4057qib7 3529 3 32 32 CD cord-005453-4057qib7 3529 4 - - SYM cord-005453-4057qib7 3529 5 64 64 CD cord-005453-4057qib7 3529 6 days day NNS cord-005453-4057qib7 3529 7 ) ) -RRB- cord-005453-4057qib7 3529 8 . . . cord-005453-4057qib7 3530 1 Documented document VBN cord-005453-4057qib7 3530 2 non non JJ cord-005453-4057qib7 3530 3 - - JJ cord-005453-4057qib7 3530 4 severe severe JJ cord-005453-4057qib7 3530 5 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 3530 6 bleeding bleeding NN cord-005453-4057qib7 3530 7 occurred occur VBD cord-005453-4057qib7 3530 8 in in IN cord-005453-4057qib7 3530 9 2 2 CD cord-005453-4057qib7 3530 10 patients patient NNS cord-005453-4057qib7 3530 11 requiring require VBG cord-005453-4057qib7 3530 12 defibrotide defibrotide NN cord-005453-4057qib7 3530 13 temporarily temporarily RB cord-005453-4057qib7 3530 14 discontinuation discontinuation VB cord-005453-4057qib7 3530 15 , , , cord-005453-4057qib7 3530 16 no no DT cord-005453-4057qib7 3530 17 other other JJ cord-005453-4057qib7 3530 18 significant significant JJ cord-005453-4057qib7 3530 19 bleedings bleeding NNS cord-005453-4057qib7 3530 20 were be VBD cord-005453-4057qib7 3530 21 experienced experience VBN cord-005453-4057qib7 3530 22 . . . cord-005453-4057qib7 3531 1 Four four CD cord-005453-4057qib7 3531 2 patients patient NNS cord-005453-4057qib7 3531 3 developed develop VBD cord-005453-4057qib7 3531 4 grade grade NN cord-005453-4057qib7 3531 5 II II NNP cord-005453-4057qib7 3531 6 - - HYPH cord-005453-4057qib7 3531 7 IV IV NNP cord-005453-4057qib7 3531 8 acute acute JJ cord-005453-4057qib7 3531 9 GVHD GVHD NNP cord-005453-4057qib7 3531 10 and and CC cord-005453-4057qib7 3531 11 no no DT cord-005453-4057qib7 3531 12 transplant transplant NN cord-005453-4057qib7 3531 13 - - HYPH cord-005453-4057qib7 3531 14 associated associate VBN cord-005453-4057qib7 3531 15 thrombotic thrombotic JJ cord-005453-4057qib7 3531 16 microangiopathy microangiopathy NNP cord-005453-4057qib7 3531 17 were be VBD cord-005453-4057qib7 3531 18 diagnosed diagnose VBN cord-005453-4057qib7 3531 19 . . . cord-005453-4057qib7 3532 1 Overall overall RB cord-005453-4057qib7 3532 2 , , , cord-005453-4057qib7 3532 3 SOS SOS NNP cord-005453-4057qib7 3532 4 / / SYM cord-005453-4057qib7 3532 5 VOD VOD NNP cord-005453-4057qib7 3532 6 occurred occur VBD cord-005453-4057qib7 3532 7 in in IN cord-005453-4057qib7 3532 8 3/11 3/11 CD cord-005453-4057qib7 3532 9 cases case NNS cord-005453-4057qib7 3532 10 within within IN cord-005453-4057qib7 3532 11 21 21 CD cord-005453-4057qib7 3532 12 days day NNS cord-005453-4057qib7 3532 13 after after IN cord-005453-4057qib7 3532 14 HSCT HSCT NNP cord-005453-4057qib7 3532 15 ( ( -LRB- cord-005453-4057qib7 3532 16 days day NNS cord-005453-4057qib7 3532 17 9 9 CD cord-005453-4057qib7 3532 18 , , , cord-005453-4057qib7 3532 19 10 10 CD cord-005453-4057qib7 3532 20 and and CC cord-005453-4057qib7 3532 21 13 13 CD cord-005453-4057qib7 3532 22 ) ) -RRB- cord-005453-4057qib7 3532 23 and and CC cord-005453-4057qib7 3532 24 no no DT cord-005453-4057qib7 3532 25 late late JJ cord-005453-4057qib7 3532 26 - - HYPH cord-005453-4057qib7 3532 27 onset onset NN cord-005453-4057qib7 3532 28 SOS SOS NNP cord-005453-4057qib7 3532 29 / / SYM cord-005453-4057qib7 3532 30 VOD VOD NNP cord-005453-4057qib7 3532 31 were be VBD cord-005453-4057qib7 3532 32 diagnosed diagnose VBN cord-005453-4057qib7 3532 33 . . . cord-005453-4057qib7 3533 1 SOS SOS NNP cord-005453-4057qib7 3533 2 / / SYM cord-005453-4057qib7 3533 3 VOD VOD NNP cord-005453-4057qib7 3533 4 was be VBD cord-005453-4057qib7 3533 5 very very RB cord-005453-4057qib7 3533 6 severe severe JJ cord-005453-4057qib7 3533 7 , , , cord-005453-4057qib7 3533 8 causing cause VBG cord-005453-4057qib7 3533 9 MODS mod NNS cord-005453-4057qib7 3533 10 and and CC cord-005453-4057qib7 3533 11 death death NN cord-005453-4057qib7 3533 12 in in IN cord-005453-4057qib7 3533 13 all all DT cord-005453-4057qib7 3533 14 3 3 CD cord-005453-4057qib7 3533 15 cases case NNS cord-005453-4057qib7 3533 16 . . . cord-005453-4057qib7 3534 1 All all DT cord-005453-4057qib7 3534 2 3 3 CD cord-005453-4057qib7 3534 3 patients patient NNS cord-005453-4057qib7 3534 4 were be VBD cord-005453-4057qib7 3534 5 characterized characterize VBN cord-005453-4057qib7 3534 6 by by IN cord-005453-4057qib7 3534 7 a a DT cord-005453-4057qib7 3534 8 common common JJ cord-005453-4057qib7 3534 9 pattern pattern NN cord-005453-4057qib7 3534 10 of of IN cord-005453-4057qib7 3534 11 very very RB cord-005453-4057qib7 3534 12 high high JJ cord-005453-4057qib7 3534 13 risk risk NN cord-005453-4057qib7 3534 14 factors factor NNS cord-005453-4057qib7 3534 15 for for IN cord-005453-4057qib7 3534 16 SOS SOS NNP cord-005453-4057qib7 3534 17 / / SYM cord-005453-4057qib7 3534 18 VOD VOD NNP cord-005453-4057qib7 3534 19 by by IN cord-005453-4057qib7 3534 20 prior prior JJ cord-005453-4057qib7 3534 21 HSCT HSCT NNP cord-005453-4057qib7 3534 22 and and CC cord-005453-4057qib7 3534 23 salvage salvage NN cord-005453-4057qib7 3534 24 treatment treatment NN cord-005453-4057qib7 3534 25 for for IN cord-005453-4057qib7 3534 26 B b NN cord-005453-4057qib7 3534 27 - - , cord-005453-4057qib7 3534 28 ALL all NN cord-005453-4057qib7 3534 29 with with IN cord-005453-4057qib7 3534 30 2 2 CD cord-005453-4057qib7 3534 31 cycles cycle NNS cord-005453-4057qib7 3534 32 of of IN cord-005453-4057qib7 3534 33 IO IO NNP cord-005453-4057qib7 3534 34 close close NN cord-005453-4057qib7 3534 35 to to IN cord-005453-4057qib7 3534 36 HSCT HSCT NNP cord-005453-4057qib7 3534 37 . . . cord-005453-4057qib7 3535 1 Furthermore furthermore RB cord-005453-4057qib7 3535 2 , , , cord-005453-4057qib7 3535 3 they -PRON- PRP cord-005453-4057qib7 3535 4 all all DT cord-005453-4057qib7 3535 5 received receive VBD cord-005453-4057qib7 3535 6 a a DT cord-005453-4057qib7 3535 7 fully fully RB cord-005453-4057qib7 3535 8 myeloablative myeloablative JJ cord-005453-4057qib7 3535 9 conditioning conditioning NN cord-005453-4057qib7 3535 10 regimen regimen NN cord-005453-4057qib7 3535 11 with with IN cord-005453-4057qib7 3535 12 Treosulfan Treosulfan NNP cord-005453-4057qib7 3535 13 and and CC cord-005453-4057qib7 3535 14 Thiotepa Thiotepa NNP cord-005453-4057qib7 3535 15 and and CC cord-005453-4057qib7 3535 16 a a DT cord-005453-4057qib7 3535 17 MMRD MMRD NNP cord-005453-4057qib7 3535 18 transplant transplant NN cord-005453-4057qib7 3535 19 . . . cord-005453-4057qib7 3536 1 Conclusions conclusion NNS cord-005453-4057qib7 3536 2 : : : cord-005453-4057qib7 3537 1 Defibrotide Defibrotide NNP cord-005453-4057qib7 3537 2 prophylaxis prophylaxis NN cord-005453-4057qib7 3537 3 was be VBD cord-005453-4057qib7 3537 4 safe safe JJ cord-005453-4057qib7 3537 5 and and CC cord-005453-4057qib7 3537 6 well well RB cord-005453-4057qib7 3537 7 tolerated tolerate VBN cord-005453-4057qib7 3537 8 with with IN cord-005453-4057qib7 3537 9 no no DT cord-005453-4057qib7 3537 10 severe severe JJ cord-005453-4057qib7 3537 11 related related JJ cord-005453-4057qib7 3537 12 complications complication NNS cord-005453-4057qib7 3537 13 . . . cord-005453-4057qib7 3538 1 SOS SOS NNP cord-005453-4057qib7 3538 2 / / SYM cord-005453-4057qib7 3538 3 VOD VOD NNP cord-005453-4057qib7 3538 4 occurred occur VBD cord-005453-4057qib7 3538 5 despite despite IN cord-005453-4057qib7 3538 6 continuous continuous JJ cord-005453-4057qib7 3538 7 DF DF NNP cord-005453-4057qib7 3538 8 prophylaxis prophylaxis NN cord-005453-4057qib7 3538 9 in in IN cord-005453-4057qib7 3538 10 3/7 3/7 CD cord-005453-4057qib7 3538 11 patients patient NNS cord-005453-4057qib7 3538 12 treated treat VBN cord-005453-4057qib7 3538 13 with with IN cord-005453-4057qib7 3538 14 Inotuzomab Inotuzomab NNP cord-005453-4057qib7 3538 15 Ozogamicin Ozogamicin NNP cord-005453-4057qib7 3538 16 close close RB cord-005453-4057qib7 3538 17 before before IN cord-005453-4057qib7 3538 18 undergoing undergo VBG cord-005453-4057qib7 3538 19 2 2 CD cord-005453-4057qib7 3538 20 nd nd NNP cord-005453-4057qib7 3538 21 transplant transplant NN cord-005453-4057qib7 3538 22 . . . cord-005453-4057qib7 3539 1 To to TO cord-005453-4057qib7 3539 2 reduce reduce VB cord-005453-4057qib7 3539 3 the the DT cord-005453-4057qib7 3539 4 incidence incidence NN cord-005453-4057qib7 3539 5 of of IN cord-005453-4057qib7 3539 6 severe severe JJ cord-005453-4057qib7 3539 7 VOD vod NN cord-005453-4057qib7 3539 8 , , , cord-005453-4057qib7 3539 9 pre pre JJ cord-005453-4057qib7 3539 10 allo allo NN cord-005453-4057qib7 3539 11 - - HYPH cord-005453-4057qib7 3539 12 HSCT HSCT NNP cord-005453-4057qib7 3539 13 treatment treatment NN cord-005453-4057qib7 3539 14 with with IN cord-005453-4057qib7 3539 15 Inotuzomab Inotuzomab NNP cord-005453-4057qib7 3539 16 Ozogamicin Ozogamicin NNP cord-005453-4057qib7 3539 17 should should MD cord-005453-4057qib7 3539 18 prompt prompt VB cord-005453-4057qib7 3539 19 avoidance avoidance NN cord-005453-4057qib7 3539 20 of of IN cord-005453-4057qib7 3539 21 other other JJ cord-005453-4057qib7 3539 22 cumulative cumulative JJ cord-005453-4057qib7 3539 23 risk risk NN cord-005453-4057qib7 3539 24 factors factor NNS cord-005453-4057qib7 3539 25 for for IN cord-005453-4057qib7 3539 26 VOD VOD NNP cord-005453-4057qib7 3539 27 , , , cord-005453-4057qib7 3539 28 such such JJ cord-005453-4057qib7 3539 29 as as IN cord-005453-4057qib7 3539 30 use use NN cord-005453-4057qib7 3539 31 of of IN cord-005453-4057qib7 3539 32 double double JJ cord-005453-4057qib7 3539 33 alkylating alkylating JJ cord-005453-4057qib7 3539 34 agents agent NNS cord-005453-4057qib7 3539 35 . . . cord-005453-4057qib7 3540 1 Disclosure disclosure NN cord-005453-4057qib7 3540 2 Background background NN cord-005453-4057qib7 3540 3 : : : cord-005453-4057qib7 3540 4 Busulfan Busulfan NNP cord-005453-4057qib7 3540 5 is be VBZ cord-005453-4057qib7 3540 6 the the DT cord-005453-4057qib7 3540 7 backbone backbone NN cord-005453-4057qib7 3540 8 of of IN cord-005453-4057qib7 3540 9 many many JJ cord-005453-4057qib7 3540 10 preparative preparative JJ cord-005453-4057qib7 3540 11 regimens regimen NNS cord-005453-4057qib7 3540 12 administered administer VBN cord-005453-4057qib7 3540 13 to to IN cord-005453-4057qib7 3540 14 children child NNS cord-005453-4057qib7 3540 15 undergoing undergo VBG cord-005453-4057qib7 3540 16 allogeneic allogeneic JJ cord-005453-4057qib7 3540 17 and and CC cord-005453-4057qib7 3540 18 autologous autologous JJ cord-005453-4057qib7 3540 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 3540 20 stem stem NN cord-005453-4057qib7 3540 21 cell cell NN cord-005453-4057qib7 3540 22 transplantation transplantation NN cord-005453-4057qib7 3540 23 ( ( -LRB- cord-005453-4057qib7 3540 24 HSCT HSCT NNP cord-005453-4057qib7 3540 25 ) ) -RRB- cord-005453-4057qib7 3540 26 . . . cord-005453-4057qib7 3541 1 Among among IN cord-005453-4057qib7 3541 2 its -PRON- PRP$ cord-005453-4057qib7 3541 3 many many JJ cord-005453-4057qib7 3541 4 long long JJ cord-005453-4057qib7 3541 5 - - HYPH cord-005453-4057qib7 3541 6 term term NN cord-005453-4057qib7 3541 7 adverse adverse JJ cord-005453-4057qib7 3541 8 effects effect NNS cord-005453-4057qib7 3541 9 , , , cord-005453-4057qib7 3541 10 Busulfan Busulfan NNP cord-005453-4057qib7 3541 11 can can MD cord-005453-4057qib7 3541 12 cause cause VB cord-005453-4057qib7 3541 13 various various JJ cord-005453-4057qib7 3541 14 degrees degree NNS cord-005453-4057qib7 3541 15 of of IN cord-005453-4057qib7 3541 16 pulmonary pulmonary JJ cord-005453-4057qib7 3541 17 injury injury NN cord-005453-4057qib7 3541 18 . . . cord-005453-4057qib7 3542 1 Although although IN cord-005453-4057qib7 3542 2 well well RB cord-005453-4057qib7 3542 3 described describe VBN cord-005453-4057qib7 3542 4 in in IN cord-005453-4057qib7 3542 5 adults adult NNS cord-005453-4057qib7 3542 6 , , , cord-005453-4057qib7 3542 7 there there EX cord-005453-4057qib7 3542 8 are be VBP cord-005453-4057qib7 3542 9 few few JJ cord-005453-4057qib7 3542 10 large large JJ cord-005453-4057qib7 3542 11 series series NN cord-005453-4057qib7 3542 12 exploring explore VBG cord-005453-4057qib7 3542 13 pulmonary pulmonary JJ cord-005453-4057qib7 3542 14 toxicity toxicity NN cord-005453-4057qib7 3542 15 of of IN cord-005453-4057qib7 3542 16 Busulfan Busulfan NNP cord-005453-4057qib7 3542 17 in in IN cord-005453-4057qib7 3542 18 children child NNS cord-005453-4057qib7 3542 19 . . . cord-005453-4057qib7 3543 1 We -PRON- PRP cord-005453-4057qib7 3543 2 describe describe VBP cord-005453-4057qib7 3543 3 long long JJ cord-005453-4057qib7 3543 4 - - HYPH cord-005453-4057qib7 3543 5 term term NN cord-005453-4057qib7 3543 6 pulmonary pulmonary JJ cord-005453-4057qib7 3543 7 follow follow NN cord-005453-4057qib7 3543 8 - - HYPH cord-005453-4057qib7 3543 9 up up NN cord-005453-4057qib7 3543 10 in in IN cord-005453-4057qib7 3543 11 a a DT cord-005453-4057qib7 3543 12 large large JJ cord-005453-4057qib7 3543 13 group group NN cord-005453-4057qib7 3543 14 of of IN cord-005453-4057qib7 3543 15 children child NNS cord-005453-4057qib7 3543 16 treated treat VBN cord-005453-4057qib7 3543 17 at at IN cord-005453-4057qib7 3543 18 a a DT cord-005453-4057qib7 3543 19 single single JJ cord-005453-4057qib7 3543 20 center center NN cord-005453-4057qib7 3543 21 who who WP cord-005453-4057qib7 3543 22 had have VBD cord-005453-4057qib7 3543 23 received receive VBN cord-005453-4057qib7 3543 24 high high JJ cord-005453-4057qib7 3543 25 - - HYPH cord-005453-4057qib7 3543 26 dose dose NN cord-005453-4057qib7 3543 27 Busulfan Busulfan NNP cord-005453-4057qib7 3543 28 and and CC cord-005453-4057qib7 3543 29 examine examine VB cord-005453-4057qib7 3543 30 the the DT cord-005453-4057qib7 3543 31 relationship relationship NN cord-005453-4057qib7 3543 32 of of IN cord-005453-4057qib7 3543 33 systemic systemic JJ cord-005453-4057qib7 3543 34 drug drug NN cord-005453-4057qib7 3543 35 exposure exposure NN cord-005453-4057qib7 3543 36 and and CC cord-005453-4057qib7 3543 37 lung lung NN cord-005453-4057qib7 3543 38 function function NN cord-005453-4057qib7 3543 39 over over IN cord-005453-4057qib7 3543 40 time time NN cord-005453-4057qib7 3543 41 . . . cord-005453-4057qib7 3544 1 Methods method NNS cord-005453-4057qib7 3544 2 : : : cord-005453-4057qib7 3545 1 All all DT cord-005453-4057qib7 3545 2 surviving survive VBG cord-005453-4057qib7 3545 3 children child NNS cord-005453-4057qib7 3545 4 who who WP cord-005453-4057qib7 3545 5 had have VBD cord-005453-4057qib7 3545 6 received receive VBN cord-005453-4057qib7 3545 7 highdose highdose NN cord-005453-4057qib7 3545 8 Busulfan Busulfan NNP cord-005453-4057qib7 3545 9 between between IN cord-005453-4057qib7 3545 10 1993 1993 CD cord-005453-4057qib7 3545 11 - - SYM cord-005453-4057qib7 3545 12 2013 2013 CD cord-005453-4057qib7 3545 13 in in IN cord-005453-4057qib7 3545 14 the the DT cord-005453-4057qib7 3545 15 context context NN cord-005453-4057qib7 3545 16 of of IN cord-005453-4057qib7 3545 17 HSCT HSCT NNP cord-005453-4057qib7 3545 18 at at IN cord-005453-4057qib7 3545 19 the the DT cord-005453-4057qib7 3545 20 Schneider Schneider NNP cord-005453-4057qib7 3545 21 Children´s Children´s NNP cord-005453-4057qib7 3545 22 Medical Medical NNP cord-005453-4057qib7 3545 23 Center Center NNP cord-005453-4057qib7 3545 24 , , , cord-005453-4057qib7 3545 25 were be VBD cord-005453-4057qib7 3545 26 referred refer VBN cord-005453-4057qib7 3545 27 for for IN cord-005453-4057qib7 3545 28 serial serial JJ cord-005453-4057qib7 3545 29 pulmonary pulmonary JJ cord-005453-4057qib7 3545 30 function function NN cord-005453-4057qib7 3545 31 monitoring monitoring NN cord-005453-4057qib7 3545 32 ( ( -LRB- cord-005453-4057qib7 3545 33 including include VBG cord-005453-4057qib7 3545 34 spirometry spirometry NN cord-005453-4057qib7 3545 35 , , , cord-005453-4057qib7 3545 36 plethysmography plethysmography NN cord-005453-4057qib7 3545 37 and and CC cord-005453-4057qib7 3545 38 diffusing diffuse VBG cord-005453-4057qib7 3545 39 capacity capacity NN cord-005453-4057qib7 3545 40 for for IN cord-005453-4057qib7 3545 41 carbon carbon NN cord-005453-4057qib7 3545 42 monoxide monoxide NN cord-005453-4057qib7 3545 43 [ [ -LRB- cord-005453-4057qib7 3545 44 DLCO DLCO NNP cord-005453-4057qib7 3545 45 ] ] -RRB- cord-005453-4057qib7 3545 46 . . . cord-005453-4057qib7 3546 1 Pre pre JJ cord-005453-4057qib7 3546 2 - - JJ cord-005453-4057qib7 3546 3 transplant transplant JJ cord-005453-4057qib7 3546 4 testing testing NN cord-005453-4057qib7 3546 5 was be VBD cord-005453-4057qib7 3546 6 available available JJ cord-005453-4057qib7 3546 7 for for IN cord-005453-4057qib7 3546 8 children child NNS cord-005453-4057qib7 3546 9 who who WP cord-005453-4057qib7 3546 10 were be VBD cord-005453-4057qib7 3546 11 old old JJ cord-005453-4057qib7 3546 12 enough enough RB cord-005453-4057qib7 3546 13 to to TO cord-005453-4057qib7 3546 14 perform perform VB cord-005453-4057qib7 3546 15 the the DT cord-005453-4057qib7 3546 16 procedure procedure NN cord-005453-4057qib7 3546 17 . . . cord-005453-4057qib7 3547 1 Spirometry Spirometry NNP cord-005453-4057qib7 3547 2 results result NNS cord-005453-4057qib7 3547 3 were be VBD cord-005453-4057qib7 3547 4 adjusted adjust VBN cord-005453-4057qib7 3547 5 according accord VBG cord-005453-4057qib7 3547 6 to to IN cord-005453-4057qib7 3547 7 the the DT cord-005453-4057qib7 3547 8 revised revise VBN cord-005453-4057qib7 3547 9 Global Global NNP cord-005453-4057qib7 3547 10 Lung Lung NNP cord-005453-4057qib7 3547 11 Initiative Initiative NNP cord-005453-4057qib7 3547 12 formulas formula NNS cord-005453-4057qib7 3547 13 for for IN cord-005453-4057qib7 3547 14 age age NN cord-005453-4057qib7 3547 15 , , , cord-005453-4057qib7 3547 16 gender gender NN cord-005453-4057qib7 3547 17 , , , cord-005453-4057qib7 3547 18 and and CC cord-005453-4057qib7 3547 19 height height NN cord-005453-4057qib7 3547 20 . . . cord-005453-4057qib7 3548 1 Pulmonary pulmonary JJ cord-005453-4057qib7 3548 2 injury injury NN cord-005453-4057qib7 3548 3 was be VBD cord-005453-4057qib7 3548 4 defined define VBN cord-005453-4057qib7 3548 5 as as IN cord-005453-4057qib7 3548 6 a a DT cord-005453-4057qib7 3548 7 Z z NN cord-005453-4057qib7 3548 8 score score NN cord-005453-4057qib7 3548 9 below below IN cord-005453-4057qib7 3548 10 -1.96 -1.96 CD cord-005453-4057qib7 3548 11 for for IN cord-005453-4057qib7 3548 12 spirometry spirometry NN cord-005453-4057qib7 3548 13 , , , cord-005453-4057qib7 3548 14 or or CC cord-005453-4057qib7 3548 15 < < XX cord-005453-4057qib7 3548 16 80 80 CD cord-005453-4057qib7 3548 17 % % NN cord-005453-4057qib7 3548 18 of of IN cord-005453-4057qib7 3548 19 predicted predict VBN cord-005453-4057qib7 3548 20 for for IN cord-005453-4057qib7 3548 21 the the DT cord-005453-4057qib7 3548 22 other other JJ cord-005453-4057qib7 3548 23 parameters parameter NNS cord-005453-4057qib7 3548 24 . . . cord-005453-4057qib7 3549 1 Busulfan Busulfan NNP cord-005453-4057qib7 3549 2 levels level NNS cord-005453-4057qib7 3549 3 were be VBD cord-005453-4057qib7 3549 4 monitored monitor VBN cord-005453-4057qib7 3549 5 following follow VBG cord-005453-4057qib7 3549 6 the the DT cord-005453-4057qib7 3549 7 second second JJ cord-005453-4057qib7 3549 8 drug drug NN cord-005453-4057qib7 3549 9 dose dose NN cord-005453-4057qib7 3549 10 . . . cord-005453-4057qib7 3550 1 All all DT cord-005453-4057qib7 3550 2 patients patient NNS cord-005453-4057qib7 3550 3 received receive VBD cord-005453-4057qib7 3550 4 Busulfan Busulfan NNP cord-005453-4057qib7 3550 5 in in IN cord-005453-4057qib7 3550 6 four four CD cord-005453-4057qib7 3550 7 daily daily JJ cord-005453-4057qib7 3550 8 doses dose NNS cord-005453-4057qib7 3550 9 . . . cord-005453-4057qib7 3551 1 Area area NN cord-005453-4057qib7 3551 2 Under under IN cord-005453-4057qib7 3551 3 the the DT cord-005453-4057qib7 3551 4 Curve curve NN cord-005453-4057qib7 3551 5 ( ( -LRB- cord-005453-4057qib7 3551 6 AUC AUC NNP cord-005453-4057qib7 3551 7 ) ) -RRB- cord-005453-4057qib7 3551 8 calculations calculation NNS cord-005453-4057qib7 3551 9 were be VBD cord-005453-4057qib7 3551 10 performed perform VBN cord-005453-4057qib7 3551 11 by by IN cord-005453-4057qib7 3551 12 Bayesian bayesian JJ cord-005453-4057qib7 3551 13 calculations calculation NNS cord-005453-4057qib7 3551 14 . . . cord-005453-4057qib7 3552 1 Results result NNS cord-005453-4057qib7 3552 2 : : : cord-005453-4057qib7 3553 1 Between between IN cord-005453-4057qib7 3553 2 1993 1993 CD cord-005453-4057qib7 3553 3 - - SYM cord-005453-4057qib7 3553 4 2013 2013 CD cord-005453-4057qib7 3553 5 , , , cord-005453-4057qib7 3553 6 263 263 CD cord-005453-4057qib7 3553 7 patients patient NNS cord-005453-4057qib7 3553 8 aged aged JJ cord-005453-4057qib7 3553 9 0 0 CD cord-005453-4057qib7 3553 10 - - SYM cord-005453-4057qib7 3553 11 18 18 CD cord-005453-4057qib7 3553 12 years year NNS cord-005453-4057qib7 3553 13 were be VBD cord-005453-4057qib7 3553 14 diagnosed diagnose VBN cord-005453-4057qib7 3553 15 with with IN cord-005453-4057qib7 3553 16 malignant malignant JJ cord-005453-4057qib7 3553 17 or or CC cord-005453-4057qib7 3553 18 non non JJ cord-005453-4057qib7 3553 19 - - JJ cord-005453-4057qib7 3553 20 malignant malignant JJ cord-005453-4057qib7 3553 21 diseases disease NNS cord-005453-4057qib7 3553 22 and and CC cord-005453-4057qib7 3553 23 treated treat VBN cord-005453-4057qib7 3553 24 with with IN cord-005453-4057qib7 3553 25 high high JJ cord-005453-4057qib7 3553 26 - - HYPH cord-005453-4057qib7 3553 27 dose dose NN cord-005453-4057qib7 3553 28 Busulfan Busulfan NNP cord-005453-4057qib7 3553 29 . . . cord-005453-4057qib7 3554 1 Of of IN cord-005453-4057qib7 3554 2 130 130 CD cord-005453-4057qib7 3554 3 shortterm shortterm JJ cord-005453-4057qib7 3554 4 survivors survivor NNS cord-005453-4057qib7 3554 5 , , , cord-005453-4057qib7 3554 6 75 75 CD cord-005453-4057qib7 3554 7 had have VBD cord-005453-4057qib7 3554 8 at at RB cord-005453-4057qib7 3554 9 least least RBS cord-005453-4057qib7 3554 10 one one CD cord-005453-4057qib7 3554 11 post post JJ cord-005453-4057qib7 3554 12 - - JJ cord-005453-4057qib7 3554 13 transplant transplant JJ cord-005453-4057qib7 3554 14 pulmonary pulmonary JJ cord-005453-4057qib7 3554 15 function function NN cord-005453-4057qib7 3554 16 evaluation evaluation NN cord-005453-4057qib7 3554 17 . . . cord-005453-4057qib7 3555 1 The the DT cord-005453-4057qib7 3555 2 mean mean JJ cord-005453-4057qib7 3555 3 age age NN cord-005453-4057qib7 3555 4 at at IN cord-005453-4057qib7 3555 5 treatment treatment NN cord-005453-4057qib7 3555 6 with with IN cord-005453-4057qib7 3555 7 Busulfan Busulfan NNP cord-005453-4057qib7 3555 8 was be VBD cord-005453-4057qib7 3555 9 7.9 7.9 CD cord-005453-4057qib7 3555 10 years year NNS cord-005453-4057qib7 3555 11 ( ( -LRB- cord-005453-4057qib7 3555 12 range range NN cord-005453-4057qib7 3555 13 , , , cord-005453-4057qib7 3555 14 0.4 0.4 CD cord-005453-4057qib7 3555 15 - - SYM cord-005453-4057qib7 3555 16 27 27 CD cord-005453-4057qib7 3555 17 years year NNS cord-005453-4057qib7 3555 18 ) ) -RRB- cord-005453-4057qib7 3555 19 . . . cord-005453-4057qib7 3556 1 Of of IN cord-005453-4057qib7 3556 2 these these DT cord-005453-4057qib7 3556 3 75 75 CD cord-005453-4057qib7 3556 4 children child NNS cord-005453-4057qib7 3556 5 , , , cord-005453-4057qib7 3556 6 22 22 CD cord-005453-4057qib7 3556 7 children child NNS cord-005453-4057qib7 3556 8 had have VBD cord-005453-4057qib7 3556 9 undergone undergo VBN cord-005453-4057qib7 3556 10 autologous autologous JJ cord-005453-4057qib7 3556 11 transplantation transplantation NN cord-005453-4057qib7 3556 12 and and CC cord-005453-4057qib7 3556 13 53 53 CD cord-005453-4057qib7 3556 14 children child NNS cord-005453-4057qib7 3556 15 had have VBD cord-005453-4057qib7 3556 16 an an DT cord-005453-4057qib7 3556 17 allogeneic allogeneic NN cord-005453-4057qib7 3556 18 transplant transplant NN cord-005453-4057qib7 3556 19 . . . cord-005453-4057qib7 3557 1 7 7 CD cord-005453-4057qib7 3557 2 of of IN cord-005453-4057qib7 3557 3 these these DT cord-005453-4057qib7 3557 4 patients patient NNS cord-005453-4057qib7 3557 5 eventually eventually RB cord-005453-4057qib7 3557 6 relapsed relapse VBD cord-005453-4057qib7 3557 7 and and CC cord-005453-4057qib7 3557 8 3 3 CD cord-005453-4057qib7 3557 9 died die VBD cord-005453-4057qib7 3557 10 . . . cord-005453-4057qib7 3558 1 26 26 CD cord-005453-4057qib7 3558 2 children child NNS cord-005453-4057qib7 3558 3 had have VBD cord-005453-4057qib7 3558 4 one one CD cord-005453-4057qib7 3558 5 or or CC cord-005453-4057qib7 3558 6 more more JJR cord-005453-4057qib7 3558 7 pulmonary pulmonary JJ cord-005453-4057qib7 3558 8 risk risk NN cord-005453-4057qib7 3558 9 factors factor NNS cord-005453-4057qib7 3558 10 before before IN cord-005453-4057qib7 3558 11 HSCT HSCT NNP cord-005453-4057qib7 3558 12 -chest -chest RBS cord-005453-4057qib7 3558 13 or or CC cord-005453-4057qib7 3558 14 upper upper JJ cord-005453-4057qib7 3558 15 abdomen abdomen NN cord-005453-4057qib7 3558 16 radiation radiation NN cord-005453-4057qib7 3558 17 ( ( -LRB- cord-005453-4057qib7 3558 18 13 13 CD cord-005453-4057qib7 3558 19 ) ) -RRB- cord-005453-4057qib7 3558 20 , , , cord-005453-4057qib7 3558 21 chest chest NN cord-005453-4057qib7 3558 22 wall wall NN cord-005453-4057qib7 3558 23 tumors tumor NNS cord-005453-4057qib7 3558 24 or or CC cord-005453-4057qib7 3558 25 lung lung NN cord-005453-4057qib7 3558 26 metastasis metastasis NN cord-005453-4057qib7 3558 27 ( ( -LRB- cord-005453-4057qib7 3558 28 8) 8) NNP cord-005453-4057qib7 3558 29 , , , cord-005453-4057qib7 3558 30 chest chest NN cord-005453-4057qib7 3558 31 surgery surgery NN cord-005453-4057qib7 3558 32 ( ( -LRB- cord-005453-4057qib7 3558 33 5 5 CD cord-005453-4057qib7 3558 34 ) ) -RRB- cord-005453-4057qib7 3558 35 , , , cord-005453-4057qib7 3558 36 prior prior JJ cord-005453-4057qib7 3558 37 administration administration NN cord-005453-4057qib7 3558 38 of of IN cord-005453-4057qib7 3558 39 pulmonary pulmonary JJ cord-005453-4057qib7 3558 40 - - HYPH cord-005453-4057qib7 3558 41 toxic toxic JJ cord-005453-4057qib7 3558 42 drug drug NN cord-005453-4057qib7 3558 43 ( ( -LRB- cord-005453-4057qib7 3558 44 3 3 CD cord-005453-4057qib7 3558 45 ) ) -RRB- cord-005453-4057qib7 3558 46 or or CC cord-005453-4057qib7 3558 47 asthma asthma NN cord-005453-4057qib7 3558 48 ( ( -LRB- cord-005453-4057qib7 3558 49 2 2 CD cord-005453-4057qib7 3558 50 ) ) -RRB- cord-005453-4057qib7 3558 51 . . . cord-005453-4057qib7 3559 1 During during IN cord-005453-4057qib7 3559 2 follow follow NN cord-005453-4057qib7 3559 3 - - HYPH cord-005453-4057qib7 3559 4 up up NN cord-005453-4057qib7 3559 5 ( ( -LRB- cord-005453-4057qib7 3559 6 up up IN cord-005453-4057qib7 3559 7 to to TO cord-005453-4057qib7 3559 8 14 14 CD cord-005453-4057qib7 3559 9 years year NNS cord-005453-4057qib7 3559 10 , , , cord-005453-4057qib7 3559 11 median median NN cord-005453-4057qib7 3559 12 5.5 5.5 CD cord-005453-4057qib7 3559 13 years year NNS cord-005453-4057qib7 3559 14 ) ) -RRB- cord-005453-4057qib7 3559 15 , , , cord-005453-4057qib7 3559 16 FEV1 FEV1 NNP cord-005453-4057qib7 3559 17 and and CC cord-005453-4057qib7 3559 18 FVC FVC NNP cord-005453-4057qib7 3559 19 spirometry spirometry NN cord-005453-4057qib7 3559 20 tests test NNS cord-005453-4057qib7 3559 21 both both CC cord-005453-4057qib7 3559 22 decreased decrease VBD cord-005453-4057qib7 3559 23 significantly significantly RB cord-005453-4057qib7 3559 24 ( ( -LRB- cord-005453-4057qib7 3559 25 p=0.002 p=0.002 NN cord-005453-4057qib7 3559 26 and and CC cord-005453-4057qib7 3559 27 0.001 0.001 CD cord-005453-4057qib7 3559 28 , , , cord-005453-4057qib7 3559 29 respectively respectively RB cord-005453-4057qib7 3559 30 ) ) -RRB- cord-005453-4057qib7 3559 31 , , , cord-005453-4057qib7 3559 32 while while IN cord-005453-4057qib7 3559 33 the the DT cord-005453-4057qib7 3559 34 decrease decrease NN cord-005453-4057qib7 3559 35 in in IN cord-005453-4057qib7 3559 36 DLCO DLCO NNP cord-005453-4057qib7 3559 37 was be VBD cord-005453-4057qib7 3559 38 not not RB cord-005453-4057qib7 3559 39 statistically statistically RB cord-005453-4057qib7 3559 40 significant significant JJ cord-005453-4057qib7 3559 41 . . . cord-005453-4057qib7 3560 1 35 35 CD cord-005453-4057qib7 3560 2 % % NN cord-005453-4057qib7 3560 3 of of IN cord-005453-4057qib7 3560 4 patients patient NNS cord-005453-4057qib7 3560 5 had have VBD cord-005453-4057qib7 3560 6 abnormal abnormal JJ cord-005453-4057qib7 3560 7 pulmonary pulmonary JJ cord-005453-4057qib7 3560 8 function function NN cord-005453-4057qib7 3560 9 tests test NNS cord-005453-4057qib7 3560 10 and and CC cord-005453-4057qib7 3560 11 seven seven CD cord-005453-4057qib7 3560 12 children child NNS cord-005453-4057qib7 3560 13 had have VBD cord-005453-4057qib7 3560 14 symptomatic symptomatic JJ cord-005453-4057qib7 3560 15 disease disease NN cord-005453-4057qib7 3560 16 which which WDT cord-005453-4057qib7 3560 17 in in IN cord-005453-4057qib7 3560 18 two two CD cord-005453-4057qib7 3560 19 may may MD cord-005453-4057qib7 3560 20 have have VB cord-005453-4057qib7 3560 21 been be VBN cord-005453-4057qib7 3560 22 manifestations manifestation NNS cord-005453-4057qib7 3560 23 of of IN cord-005453-4057qib7 3560 24 GVHD GVHD NNP cord-005453-4057qib7 3560 25 . . . cord-005453-4057qib7 3561 1 Interestingly interestingly RB cord-005453-4057qib7 3561 2 , , , cord-005453-4057qib7 3561 3 no no DT cord-005453-4057qib7 3561 4 correlation correlation NN cord-005453-4057qib7 3561 5 was be VBD cord-005453-4057qib7 3561 6 found find VBN cord-005453-4057qib7 3561 7 between between IN cord-005453-4057qib7 3561 8 Busulfan Busulfan NNP cord-005453-4057qib7 3561 9 AUC AUC NNP cord-005453-4057qib7 3561 10 , , , cord-005453-4057qib7 3561 11 Busulfan Busulfan NNP cord-005453-4057qib7 3561 12 peak peak NN cord-005453-4057qib7 3561 13 levels level NNS cord-005453-4057qib7 3561 14 , , , cord-005453-4057qib7 3561 15 the the DT cord-005453-4057qib7 3561 16 number number NN cord-005453-4057qib7 3561 17 of of IN cord-005453-4057qib7 3561 18 Busulfan Busulfan NNP cord-005453-4057qib7 3561 19 doses dose NNS cord-005453-4057qib7 3561 20 administered administer VBN cord-005453-4057qib7 3561 21 , , , cord-005453-4057qib7 3561 22 the the DT cord-005453-4057qib7 3561 23 type type NN cord-005453-4057qib7 3561 24 of of IN cord-005453-4057qib7 3561 25 transplantation transplantation NN cord-005453-4057qib7 3561 26 ( ( -LRB- cord-005453-4057qib7 3561 27 autologous autologous JJ cord-005453-4057qib7 3561 28 vs. vs. FW cord-005453-4057qib7 3561 29 allogeneic allogeneic NN cord-005453-4057qib7 3561 30 ) ) -RRB- cord-005453-4057qib7 3561 31 or or CC cord-005453-4057qib7 3561 32 primary primary JJ cord-005453-4057qib7 3561 33 disease disease NN cord-005453-4057qib7 3561 34 to to IN cord-005453-4057qib7 3561 35 pulmonary pulmonary JJ cord-005453-4057qib7 3561 36 injury injury NN cord-005453-4057qib7 3561 37 . . . cord-005453-4057qib7 3562 1 Even even RB cord-005453-4057qib7 3562 2 after after IN cord-005453-4057qib7 3562 3 censoring censor VBG cord-005453-4057qib7 3562 4 of of IN cord-005453-4057qib7 3562 5 children child NNS cord-005453-4057qib7 3562 6 with with IN cord-005453-4057qib7 3562 7 pre pre JJ cord-005453-4057qib7 3562 8 - - JJ cord-005453-4057qib7 3562 9 transplant transplant JJ cord-005453-4057qib7 3562 10 pulmonary pulmonary JJ cord-005453-4057qib7 3562 11 risk risk NN cord-005453-4057qib7 3562 12 factors factor NNS cord-005453-4057qib7 3562 13 we -PRON- PRP cord-005453-4057qib7 3562 14 noted note VBD cord-005453-4057qib7 3562 15 a a DT cord-005453-4057qib7 3562 16 decrease decrease NN cord-005453-4057qib7 3562 17 of of IN cord-005453-4057qib7 3562 18 FEV1 FEV1 NNP cord-005453-4057qib7 3562 19 and and CC cord-005453-4057qib7 3562 20 FVC FVC NNP cord-005453-4057qib7 3562 21 . . . cord-005453-4057qib7 3563 1 Conclusions conclusion NNS cord-005453-4057qib7 3563 2 : : : cord-005453-4057qib7 3564 1 As as IN cord-005453-4057qib7 3564 2 in in IN cord-005453-4057qib7 3564 3 adults adult NNS cord-005453-4057qib7 3564 4 , , , cord-005453-4057qib7 3564 5 pulmonary pulmonary JJ cord-005453-4057qib7 3564 6 injury injury NN cord-005453-4057qib7 3564 7 is be VBZ cord-005453-4057qib7 3564 8 observed observe VBN cord-005453-4057qib7 3564 9 in in IN cord-005453-4057qib7 3564 10 children child NNS cord-005453-4057qib7 3564 11 treated treat VBN cord-005453-4057qib7 3564 12 with with IN cord-005453-4057qib7 3564 13 high high JJ cord-005453-4057qib7 3564 14 - - HYPH cord-005453-4057qib7 3564 15 dose dose NN cord-005453-4057qib7 3564 16 Busulfan Busulfan NNP cord-005453-4057qib7 3564 17 prior prior RB cord-005453-4057qib7 3564 18 to to IN cord-005453-4057qib7 3564 19 HSCT HSCT NNP cord-005453-4057qib7 3564 20 . . . cord-005453-4057qib7 3565 1 No no DT cord-005453-4057qib7 3565 2 correlation correlation NN cord-005453-4057qib7 3565 3 was be VBD cord-005453-4057qib7 3565 4 observed observe VBN cord-005453-4057qib7 3565 5 between between IN cord-005453-4057qib7 3565 6 Busulfan Busulfan NNP cord-005453-4057qib7 3565 7 AUC AUC NNP cord-005453-4057qib7 3565 8 and and CC cord-005453-4057qib7 3565 9 pulmonary pulmonary JJ cord-005453-4057qib7 3565 10 injury injury NN cord-005453-4057qib7 3565 11 . . . cord-005453-4057qib7 3566 1 Follow follow VB cord-005453-4057qib7 3566 2 - - HYPH cord-005453-4057qib7 3566 3 up up NN cord-005453-4057qib7 3566 4 of of IN cord-005453-4057qib7 3566 5 children child NNS cord-005453-4057qib7 3566 6 who who WP cord-005453-4057qib7 3566 7 receive receive VBP cord-005453-4057qib7 3566 8 this this DT cord-005453-4057qib7 3566 9 drug drug NN cord-005453-4057qib7 3566 10 should should MD cord-005453-4057qib7 3566 11 include include VB cord-005453-4057qib7 3566 12 regular regular JJ cord-005453-4057qib7 3566 13 pulmonary pulmonary JJ cord-005453-4057qib7 3566 14 monitoring monitoring NN cord-005453-4057qib7 3566 15 , , , cord-005453-4057qib7 3566 16 referral referral NN cord-005453-4057qib7 3566 17 to to IN cord-005453-4057qib7 3566 18 a a DT cord-005453-4057qib7 3566 19 pulmonologist pulmonologist NN cord-005453-4057qib7 3566 20 when when WRB cord-005453-4057qib7 3566 21 subclinical subclinical JJ cord-005453-4057qib7 3566 22 pulmonary pulmonary JJ cord-005453-4057qib7 3566 23 compromise compromise NN cord-005453-4057qib7 3566 24 is be VBZ cord-005453-4057qib7 3566 25 found find VBN cord-005453-4057qib7 3566 26 , , , cord-005453-4057qib7 3566 27 and and CC cord-005453-4057qib7 3566 28 counseling counsel VBG cord-005453-4057qib7 3566 29 regarding regard VBG cord-005453-4057qib7 3566 30 measures measure NNS cord-005453-4057qib7 3566 31 that that WDT cord-005453-4057qib7 3566 32 might may MD cord-005453-4057qib7 3566 33 prevent prevent VB cord-005453-4057qib7 3566 34 or or CC cord-005453-4057qib7 3566 35 ameliorate ameliorate VB cord-005453-4057qib7 3566 36 pulmonary pulmonary JJ cord-005453-4057qib7 3566 37 damage damage NN cord-005453-4057qib7 3566 38 . . . cord-005453-4057qib7 3567 1 Continued continue VBN cord-005453-4057qib7 3567 2 follow follow NN cord-005453-4057qib7 3567 3 - - HYPH cord-005453-4057qib7 3567 4 up up NN cord-005453-4057qib7 3567 5 of of IN cord-005453-4057qib7 3567 6 this this DT cord-005453-4057qib7 3567 7 cohort cohort NN cord-005453-4057qib7 3567 8 of of IN cord-005453-4057qib7 3567 9 patients patient NNS cord-005453-4057qib7 3567 10 should should MD cord-005453-4057qib7 3567 11 inform inform VB cord-005453-4057qib7 3567 12 our -PRON- PRP$ cord-005453-4057qib7 3567 13 pretransplant pretransplant JJ cord-005453-4057qib7 3567 14 patient patient NN cord-005453-4057qib7 3567 15 information information NN cord-005453-4057qib7 3567 16 sessions session NNS cord-005453-4057qib7 3567 17 , , , cord-005453-4057qib7 3567 18 and and CC cord-005453-4057qib7 3567 19 the the DT cord-005453-4057qib7 3567 20 future future JJ cord-005453-4057qib7 3567 21 use use NN cord-005453-4057qib7 3567 22 of of IN cord-005453-4057qib7 3567 23 Busulfan Busulfan NNP cord-005453-4057qib7 3567 24 in in IN cord-005453-4057qib7 3567 25 children child NNS cord-005453-4057qib7 3567 26 . . . cord-005453-4057qib7 3568 1 Disclosure disclosure NN cord-005453-4057qib7 3568 2 : : : cord-005453-4057qib7 3568 3 Nothing nothing NN cord-005453-4057qib7 3568 4 to to TO cord-005453-4057qib7 3568 5 declare declare VB cord-005453-4057qib7 3568 6 Background background NN cord-005453-4057qib7 3568 7 : : : cord-005453-4057qib7 3568 8 Transplant transplant NN cord-005453-4057qib7 3568 9 - - HYPH cord-005453-4057qib7 3568 10 associated associate VBN cord-005453-4057qib7 3568 11 thrombotic thrombotic JJ cord-005453-4057qib7 3568 12 microangiopathy microangiopathy NNP cord-005453-4057qib7 3568 13 ( ( -LRB- cord-005453-4057qib7 3568 14 TA TA NNP cord-005453-4057qib7 3568 15 - - HYPH cord-005453-4057qib7 3568 16 TMA TMA NNP cord-005453-4057qib7 3568 17 ) ) -RRB- cord-005453-4057qib7 3568 18 is be VBZ cord-005453-4057qib7 3568 19 a a DT cord-005453-4057qib7 3568 20 specific specific JJ cord-005453-4057qib7 3568 21 complication complication NN cord-005453-4057qib7 3568 22 of of IN cord-005453-4057qib7 3568 23 allogeneic allogeneic JJ cord-005453-4057qib7 3568 24 hematopoietic hematopoietic JJ cord-005453-4057qib7 3568 25 stem stem NN cord-005453-4057qib7 3568 26 cell cell NN cord-005453-4057qib7 3568 27 transplantation transplantation NN cord-005453-4057qib7 3568 28 ( ( -LRB- cord-005453-4057qib7 3568 29 HSCT HSCT NNP cord-005453-4057qib7 3568 30 ) ) -RRB- cord-005453-4057qib7 3568 31 . . . cord-005453-4057qib7 3569 1 Post post JJ cord-005453-4057qib7 3569 2 - - JJ cord-005453-4057qib7 3569 3 HSCT HSCT NNP cord-005453-4057qib7 3569 4 TMA TMA NNP cord-005453-4057qib7 3569 5 has have VBZ cord-005453-4057qib7 3569 6 been be VBN cord-005453-4057qib7 3569 7 attributed attribute VBN cord-005453-4057qib7 3569 8 to to IN cord-005453-4057qib7 3569 9 the the DT cord-005453-4057qib7 3569 10 vascular vascular JJ cord-005453-4057qib7 3569 11 endothelial endothelial JJ cord-005453-4057qib7 3569 12 damage damage NN cord-005453-4057qib7 3569 13 caused cause VBN cord-005453-4057qib7 3569 14 by by IN cord-005453-4057qib7 3569 15 high high JJ cord-005453-4057qib7 3569 16 - - HYPH cord-005453-4057qib7 3569 17 dose dose NN cord-005453-4057qib7 3569 18 chemotherapy chemotherapy NN cord-005453-4057qib7 3569 19 , , , cord-005453-4057qib7 3569 20 calcineurin calcineurin NN cord-005453-4057qib7 3569 21 inhibitors inhibitor NNS cord-005453-4057qib7 3569 22 ( ( -LRB- cord-005453-4057qib7 3569 23 CNIs CNIs NNP cord-005453-4057qib7 3569 24 ) ) -RRB- cord-005453-4057qib7 3569 25 , , , cord-005453-4057qib7 3569 26 graft graft NN cord-005453-4057qib7 3569 27 - - HYPH cord-005453-4057qib7 3569 28 versus versus IN cord-005453-4057qib7 3569 29 - - HYPH cord-005453-4057qib7 3569 30 host host NN cord-005453-4057qib7 3569 31 disease disease NN cord-005453-4057qib7 3569 32 ( ( -LRB- cord-005453-4057qib7 3569 33 GVHD GVHD NNP cord-005453-4057qib7 3569 34 ) ) -RRB- cord-005453-4057qib7 3569 35 , , , cord-005453-4057qib7 3569 36 infections infection NNS cord-005453-4057qib7 3569 37 . . . cord-005453-4057qib7 3570 1 There there EX cord-005453-4057qib7 3570 2 is be VBZ cord-005453-4057qib7 3570 3 a a DT cord-005453-4057qib7 3570 4 little little JJ cord-005453-4057qib7 3570 5 evidence evidence NN cord-005453-4057qib7 3570 6 published publish VBN cord-005453-4057qib7 3570 7 regarding regard VBG cord-005453-4057qib7 3570 8 the the DT cord-005453-4057qib7 3570 9 efficacy efficacy NN cord-005453-4057qib7 3570 10 and and CC cord-005453-4057qib7 3570 11 factors factor NNS cord-005453-4057qib7 3570 12 influencing influence VBG cord-005453-4057qib7 3570 13 the the DT cord-005453-4057qib7 3570 14 outcome outcome NN cord-005453-4057qib7 3570 15 of of IN cord-005453-4057qib7 3570 16 withdrawal withdrawal NN cord-005453-4057qib7 3570 17 of of IN cord-005453-4057qib7 3570 18 CNIs cni NNS cord-005453-4057qib7 3570 19 . . . cord-005453-4057qib7 3571 1 Methods method NNS cord-005453-4057qib7 3571 2 : : : cord-005453-4057qib7 3572 1 The the DT cord-005453-4057qib7 3572 2 analysis analysis NN cord-005453-4057qib7 3572 3 comprised comprise VBD cord-005453-4057qib7 3572 4 a a DT cord-005453-4057qib7 3572 5 total total NN cord-005453-4057qib7 3572 6 of of IN cord-005453-4057qib7 3572 7 54 54 CD cord-005453-4057qib7 3572 8 patients patient NNS cord-005453-4057qib7 3572 9 , , , cord-005453-4057qib7 3572 10 with with IN cord-005453-4057qib7 3572 11 diagnosed diagnosed JJ cord-005453-4057qib7 3572 12 hematologic hematologic JJ cord-005453-4057qib7 3572 13 malignancy malignancy NN cord-005453-4057qib7 3572 14 ( ( -LRB- cord-005453-4057qib7 3572 15 AML AML NNP cord-005453-4057qib7 3572 16 ( ( -LRB- cord-005453-4057qib7 3572 17 16 16 CD cord-005453-4057qib7 3572 18 ) ) -RRB- cord-005453-4057qib7 3572 19 , , , cord-005453-4057qib7 3572 20 ALL all DT cord-005453-4057qib7 3572 21 ( ( -LRB- cord-005453-4057qib7 3572 22 12 12 CD cord-005453-4057qib7 3572 23 ) ) -RRB- cord-005453-4057qib7 3572 24 , , , cord-005453-4057qib7 3572 25 MDS MDS NNP cord-005453-4057qib7 3572 26 ( ( -LRB- cord-005453-4057qib7 3572 27 4 4 CD cord-005453-4057qib7 3572 28 ) ) -RRB- cord-005453-4057qib7 3572 29 , , , cord-005453-4057qib7 3572 30 Hodgkin Hodgkin NNP cord-005453-4057qib7 3572 31 lymphoma lymphoma NN cord-005453-4057qib7 3572 32 ( ( -LRB- cord-005453-4057qib7 3572 33 5 5 CD cord-005453-4057qib7 3572 34 ) ) -RRB- cord-005453-4057qib7 3572 35 , , , cord-005453-4057qib7 3572 36 CML CML NNP cord-005453-4057qib7 3572 37 ( ( -LRB- cord-005453-4057qib7 3572 38 3 3 CD cord-005453-4057qib7 3572 39 ) ) -RRB- cord-005453-4057qib7 3572 40 and and CC cord-005453-4057qib7 3572 41 Neuroblastoma Neuroblastoma NNP cord-005453-4057qib7 3572 42 ( ( -LRB- cord-005453-4057qib7 3572 43 1 1 CD cord-005453-4057qib7 3572 44 ) ) -RRB- cord-005453-4057qib7 3572 45 received receive VBD cord-005453-4057qib7 3572 46 allo allo NN cord-005453-4057qib7 3572 47 - - HYPH cord-005453-4057qib7 3572 48 SCT SCT NNP cord-005453-4057qib7 3572 49 , , , cord-005453-4057qib7 3572 50 from from IN cord-005453-4057qib7 3572 51 a a DT cord-005453-4057qib7 3572 52 matched match VBN cord-005453-4057qib7 3572 53 related relate VBN cord-005453-4057qib7 3572 54 , , , cord-005453-4057qib7 3572 55 unrelated unrelated JJ cord-005453-4057qib7 3572 56 or or CC cord-005453-4057qib7 3572 57 haploidentical haploidentical JJ cord-005453-4057qib7 3572 58 donor donor NN cord-005453-4057qib7 3572 59 between between IN cord-005453-4057qib7 3572 60 2007 2007 CD cord-005453-4057qib7 3572 61 and and CC cord-005453-4057qib7 3572 62 2018 2018 CD cord-005453-4057qib7 3572 63 . . . cord-005453-4057qib7 3573 1 Patients patient NNS cord-005453-4057qib7 3573 2 were be VBD cord-005453-4057qib7 3573 3 diagnosed diagnose VBN cord-005453-4057qib7 3573 4 with with IN cord-005453-4057qib7 3573 5 TA TA NNP cord-005453-4057qib7 3573 6 - - HYPH cord-005453-4057qib7 3573 7 TMA TMA NNP cord-005453-4057qib7 3573 8 based base VBN cord-005453-4057qib7 3573 9 on on IN cord-005453-4057qib7 3573 10 Cho Cho NNP cord-005453-4057qib7 3573 11 criteria criterion NNS cord-005453-4057qib7 3573 12 . . . cord-005453-4057qib7 3574 1 The the DT cord-005453-4057qib7 3574 2 median median JJ cord-005453-4057qib7 3574 3 age age NN cord-005453-4057qib7 3574 4 of of IN cord-005453-4057qib7 3574 5 patients patient NNS cord-005453-4057qib7 3574 6 was be VBD cord-005453-4057qib7 3574 7 23 23 CD cord-005453-4057qib7 3574 8 ( ( -LRB- cord-005453-4057qib7 3574 9 37 37 CD cord-005453-4057qib7 3574 10 adults adult NNS cord-005453-4057qib7 3574 11 , , , cord-005453-4057qib7 3574 12 17 17 CD cord-005453-4057qib7 3574 13 children child NNS cord-005453-4057qib7 3574 14 ) ) -RRB- cord-005453-4057qib7 3574 15 . . . cord-005453-4057qib7 3575 1 GVHD GVHD NNP cord-005453-4057qib7 3575 2 prophylaxis prophylaxis NN cord-005453-4057qib7 3575 3 was be VBD cord-005453-4057qib7 3575 4 performed perform VBN cord-005453-4057qib7 3575 5 with with IN cord-005453-4057qib7 3575 6 tacrolimus tacrolimus NNP cord-005453-4057qib7 3575 7 ( ( -LRB- cord-005453-4057qib7 3575 8 Tac Tac NNP cord-005453-4057qib7 3575 9 ) ) -RRB- cord-005453-4057qib7 3575 10 in in IN cord-005453-4057qib7 3575 11 42 42 CD cord-005453-4057qib7 3575 12 , , , cord-005453-4057qib7 3575 13 cyclosporine cyclosporine NN cord-005453-4057qib7 3575 14 A(CsA a(csa CD cord-005453-4057qib7 3575 15 ) ) -RRB- cord-005453-4057qib7 3575 16 in in IN cord-005453-4057qib7 3575 17 11 11 CD cord-005453-4057qib7 3575 18 , , , cord-005453-4057qib7 3575 19 combination combination NN cord-005453-4057qib7 3575 20 tacrolimus+sirolimus tacrolimus+sirolimus NN cord-005453-4057qib7 3575 21 ( ( -LRB- cord-005453-4057qib7 3575 22 Sir Sir NNP cord-005453-4057qib7 3575 23 ) ) -RRB- cord-005453-4057qib7 3575 24 in in IN cord-005453-4057qib7 3575 25 12 12 CD cord-005453-4057qib7 3575 26 . . . cord-005453-4057qib7 3576 1 24 24 CD cord-005453-4057qib7 3576 2 patients patient NNS cord-005453-4057qib7 3576 3 received receive VBD cord-005453-4057qib7 3576 4 ATG ATG NNP cord-005453-4057qib7 3576 5 and and CC cord-005453-4057qib7 3576 6 26 26 CD cord-005453-4057qib7 3576 7 PTCy PTCy NNS cord-005453-4057qib7 3576 8 . . . cord-005453-4057qib7 3577 1 Withdrawal withdrawal NN cord-005453-4057qib7 3577 2 of of IN cord-005453-4057qib7 3577 3 CNIs cni NNS cord-005453-4057qib7 3577 4 was be VBD cord-005453-4057qib7 3577 5 accompanied accompany VBN cord-005453-4057qib7 3577 6 by by IN cord-005453-4057qib7 3577 7 administration administration NN cord-005453-4057qib7 3577 8 of of IN cord-005453-4057qib7 3577 9 systemic systemic JJ cord-005453-4057qib7 3577 10 steroids steroid NNS cord-005453-4057qib7 3577 11 ( ( -LRB- cord-005453-4057qib7 3577 12 21 21 CD cord-005453-4057qib7 3577 13 patients patient NNS cord-005453-4057qib7 3577 14 ) ) -RRB- cord-005453-4057qib7 3577 15 or or CC cord-005453-4057qib7 3577 16 substitution substitution NN cord-005453-4057qib7 3577 17 with with IN cord-005453-4057qib7 3577 18 Sir Sir NNP cord-005453-4057qib7 3577 19 after after IN cord-005453-4057qib7 3577 20 reaching reach VBG cord-005453-4057qib7 3577 21 levels level NNS cord-005453-4057qib7 3577 22 of of IN cord-005453-4057qib7 3577 23 CsA CsA NNP cord-005453-4057qib7 3577 24 < < XX cord-005453-4057qib7 3577 25 100 100 CD cord-005453-4057qib7 3577 26 ng ng NNP cord-005453-4057qib7 3577 27 / / SYM cord-005453-4057qib7 3577 28 ml ml NN cord-005453-4057qib7 3577 29 or or CC cord-005453-4057qib7 3577 30 Tac Tac NNP cord-005453-4057qib7 3577 31 < < XX cord-005453-4057qib7 3577 32 3 3 CD cord-005453-4057qib7 3577 33 ng ng NNP cord-005453-4057qib7 3577 34 / / SYM cord-005453-4057qib7 3577 35 ml ml NN cord-005453-4057qib7 3577 36 in in IN cord-005453-4057qib7 3577 37 13 13 CD cord-005453-4057qib7 3577 38 . . . cord-005453-4057qib7 3578 1 The the DT cord-005453-4057qib7 3578 2 target target NN cord-005453-4057qib7 3578 3 concentration concentration NN cord-005453-4057qib7 3578 4 of of IN cord-005453-4057qib7 3578 5 Sir Sir NNP cord-005453-4057qib7 3578 6 was be VBD cord-005453-4057qib7 3578 7 3 3 CD cord-005453-4057qib7 3578 8 - - SYM cord-005453-4057qib7 3578 9 9 9 CD cord-005453-4057qib7 3578 10 ng ng NN cord-005453-4057qib7 3578 11 / / SYM cord-005453-4057qib7 3578 12 ml ml NN cord-005453-4057qib7 3578 13 . . . cord-005453-4057qib7 3579 1 In in IN cord-005453-4057qib7 3579 2 pediatric pediatric JJ cord-005453-4057qib7 3579 3 patients patient NNS cord-005453-4057qib7 3579 4 who who WP cord-005453-4057qib7 3579 5 received receive VBD cord-005453-4057qib7 3579 6 combination combination NN cord-005453-4057qib7 3579 7 Tac+Sir Tac+Sir NNP cord-005453-4057qib7 3579 8 , , , cord-005453-4057qib7 3579 9 the the DT cord-005453-4057qib7 3579 10 Tac Tac NNP cord-005453-4057qib7 3579 11 was be VBD cord-005453-4057qib7 3579 12 discontinued discontinue VBN cord-005453-4057qib7 3579 13 in in IN cord-005453-4057qib7 3579 14 one one CD cord-005453-4057qib7 3579 15 step step NN cord-005453-4057qib7 3579 16 while while IN cord-005453-4057qib7 3579 17 Sir Sir NNP cord-005453-4057qib7 3579 18 continued continue VBD cord-005453-4057qib7 3579 19 . . . cord-005453-4057qib7 3580 1 Median median JJ cord-005453-4057qib7 3580 2 time time NN cord-005453-4057qib7 3580 3 to to IN cord-005453-4057qib7 3580 4 development development NN cord-005453-4057qib7 3581 1 TMA TMA NNP cord-005453-4057qib7 3581 2 was be VBD cord-005453-4057qib7 3581 3 31,5 31,5 CD cord-005453-4057qib7 3581 4 days day NNS cord-005453-4057qib7 3581 5 after after IN cord-005453-4057qib7 3581 6 allo allo NN cord-005453-4057qib7 3581 7 - - HYPH cord-005453-4057qib7 3581 8 SCT SCT NNP cord-005453-4057qib7 3581 9 ( ( -LRB- cord-005453-4057qib7 3581 10 range range NNP cord-005453-4057qib7 3581 11 1 1 CD cord-005453-4057qib7 3581 12 - - SYM cord-005453-4057qib7 3581 13 408 408 CD cord-005453-4057qib7 3581 14 ) ) -RRB- cord-005453-4057qib7 3581 15 . . . cord-005453-4057qib7 3582 1 Median median JJ cord-005453-4057qib7 3582 2 follow follow NN cord-005453-4057qib7 3582 3 - - HYPH cord-005453-4057qib7 3582 4 up up NN cord-005453-4057qib7 3582 5 of of IN cord-005453-4057qib7 3582 6 surviving survive VBG cord-005453-4057qib7 3582 7 patients patient NNS cord-005453-4057qib7 3582 8 was be VBD cord-005453-4057qib7 3582 9 395 395 CD cord-005453-4057qib7 3582 10 days day NNS cord-005453-4057qib7 3582 11 . . . cord-005453-4057qib7 3583 1 The the DT cord-005453-4057qib7 3583 2 primary primary JJ cord-005453-4057qib7 3583 3 outcome outcome NN cord-005453-4057qib7 3583 4 was be VBD cord-005453-4057qib7 3583 5 overall overall JJ cord-005453-4057qib7 3583 6 survival survival NN cord-005453-4057qib7 3583 7 ( ( -LRB- cord-005453-4057qib7 3583 8 OS OS NNP cord-005453-4057qib7 3583 9 ) ) -RRB- cord-005453-4057qib7 3583 10 up up IN cord-005453-4057qib7 3583 11 to to TO cord-005453-4057qib7 3583 12 2 2 CD cord-005453-4057qib7 3583 13 years year NNS cord-005453-4057qib7 3583 14 after after IN cord-005453-4057qib7 3583 15 development development NN cord-005453-4057qib7 3583 16 of of IN cord-005453-4057qib7 3583 17 TA TA NNP cord-005453-4057qib7 3583 18 - - HYPH cord-005453-4057qib7 3583 19 TMA TMA NNP cord-005453-4057qib7 3583 20 . . . cord-005453-4057qib7 3584 1 Results result NNS cord-005453-4057qib7 3584 2 : : : cord-005453-4057qib7 3585 1 The the DT cord-005453-4057qib7 3585 2 following follow VBG cord-005453-4057qib7 3585 3 significant significant JJ cord-005453-4057qib7 3585 4 predictors predictor NNS cord-005453-4057qib7 3585 5 of of IN cord-005453-4057qib7 3585 6 2-year 2-year CD cord-005453-4057qib7 3585 7 OS OS NNP cord-005453-4057qib7 3585 8 were be VBD cord-005453-4057qib7 3585 9 identified identify VBN cord-005453-4057qib7 3585 10 : : : cord-005453-4057qib7 3585 11 Tac Tac NNP cord-005453-4057qib7 3585 12 replacement replacement NN cord-005453-4057qib7 3585 13 with with IN cord-005453-4057qib7 3585 14 Sir Sir NNP cord-005453-4057qib7 3585 15 ( ( -LRB- cord-005453-4057qib7 3585 16 p p NN cord-005453-4057qib7 3585 17 < < XX cord-005453-4057qib7 3585 18 0,001 0,001 CD cord-005453-4057qib7 3585 19 ) ) -RRB- cord-005453-4057qib7 3585 20 , , , cord-005453-4057qib7 3585 21 PTCy PTCy NNS cord-005453-4057qib7 3585 22 in in IN cord-005453-4057qib7 3585 23 prophylaxis prophylaxis NN cord-005453-4057qib7 3585 24 ( ( -LRB- cord-005453-4057qib7 3585 25 p p NN cord-005453-4057qib7 3585 26 < < XX cord-005453-4057qib7 3585 27 0,001 0,001 CD cord-005453-4057qib7 3585 28 ) ) -RRB- cord-005453-4057qib7 3585 29 , , , cord-005453-4057qib7 3585 30 acute acute JJ cord-005453-4057qib7 3585 31 GVHD GVHD NNP cord-005453-4057qib7 3585 32 ( ( -LRB- cord-005453-4057qib7 3585 33 aGVHD aGVHD NNP cord-005453-4057qib7 3585 34 ) ) -RRB- cord-005453-4057qib7 3585 35 grade grade NN cord-005453-4057qib7 3585 36 2 2 CD cord-005453-4057qib7 3585 37 - - SYM cord-005453-4057qib7 3585 38 4 4 CD cord-005453-4057qib7 3585 39 ( ( -LRB- cord-005453-4057qib7 3585 40 p=0,029 p=0,029 NNP cord-005453-4057qib7 3585 41 ) ) -RRB- cord-005453-4057qib7 3585 42 , , , cord-005453-4057qib7 3585 43 previous previous JJ cord-005453-4057qib7 3585 44 sepsis sepsis NN cord-005453-4057qib7 3585 45 ( ( -LRB- cord-005453-4057qib7 3585 46 p=0,003 p=0,003 NNP cord-005453-4057qib7 3585 47 ) ) -RRB- cord-005453-4057qib7 3585 48 , , , cord-005453-4057qib7 3585 49 level level NN cord-005453-4057qib7 3585 50 of of IN cord-005453-4057qib7 3585 51 LDH LDH NNP cord-005453-4057qib7 3585 52 in in IN cord-005453-4057qib7 3585 53 debut debut NN cord-005453-4057qib7 3585 54 ( ( -LRB- cord-005453-4057qib7 3585 55 p=0,001 p=0,001 NNP cord-005453-4057qib7 3585 56 ) ) -RRB- cord-005453-4057qib7 3585 57 , , , cord-005453-4057qib7 3585 58 combination combination NN cord-005453-4057qib7 3585 59 Sir+Tac Sir+Tac NNP cord-005453-4057qib7 3585 60 in in IN cord-005453-4057qib7 3585 61 prophylaxis prophylaxis NN cord-005453-4057qib7 3585 62 ( ( -LRB- cord-005453-4057qib7 3585 63 p=0,05 p=0,05 NNP cord-005453-4057qib7 3585 64 ) ) -RRB- cord-005453-4057qib7 3585 65 , , , cord-005453-4057qib7 3585 66 major major JJ cord-005453-4057qib7 3585 67 AB0-mismatch ab0-mismatch NN cord-005453-4057qib7 3585 68 ( ( -LRB- cord-005453-4057qib7 3585 69 p=0,022 p=0,022 NNP cord-005453-4057qib7 3585 70 ) ) -RRB- cord-005453-4057qib7 3585 71 , , . cord-005453-4057qib7 3586 1 severity severity NN cord-005453-4057qib7 3586 2 of of IN cord-005453-4057qib7 3586 3 CNS CNS NNP cord-005453-4057qib7 3586 4 symptoms symptom NNS cord-005453-4057qib7 3586 5 ( ( -LRB- cord-005453-4057qib7 3586 6 p p NN cord-005453-4057qib7 3586 7 < < XX cord-005453-4057qib7 3586 8 0,001 0,001 CD cord-005453-4057qib7 3586 9 ) ) -RRB- cord-005453-4057qib7 3586 10 . . . cord-005453-4057qib7 3587 1 There there EX cord-005453-4057qib7 3587 2 was be VBD cord-005453-4057qib7 3587 3 no no DT cord-005453-4057qib7 3587 4 significant significant JJ cord-005453-4057qib7 3587 5 difference difference NN cord-005453-4057qib7 3587 6 in in IN cord-005453-4057qib7 3587 7 OS OS NNP cord-005453-4057qib7 3587 8 according accord VBG cord-005453-4057qib7 3587 9 to to IN cord-005453-4057qib7 3587 10 patients patient NNS cord-005453-4057qib7 3587 11 ' ' POS cord-005453-4057qib7 3587 12 age age NN cord-005453-4057qib7 3587 13 , , , cord-005453-4057qib7 3587 14 sex sex NN cord-005453-4057qib7 3587 15 , , , cord-005453-4057qib7 3587 16 " " `` cord-005453-4057qib7 3587 17 salvage salvage NN cord-005453-4057qib7 3587 18 " " '' cord-005453-4057qib7 3587 19 disease disease NN cord-005453-4057qib7 3587 20 status status NN cord-005453-4057qib7 3587 21 at at IN cord-005453-4057qib7 3587 22 transplantation transplantation NN cord-005453-4057qib7 3587 23 , , , cord-005453-4057qib7 3587 24 previous previous JJ cord-005453-4057qib7 3587 25 VOD vod NN cord-005453-4057qib7 3587 26 , , , cord-005453-4057qib7 3587 27 viral viral JJ cord-005453-4057qib7 3587 28 ( ( -LRB- cord-005453-4057qib7 3587 29 HHV HHV NNP cord-005453-4057qib7 3587 30 1,2,6 1,2,6 CD cord-005453-4057qib7 3587 31 , , , cord-005453-4057qib7 3587 32 CMV CMV NNP cord-005453-4057qib7 3587 33 , , , cord-005453-4057qib7 3587 34 EBV EBV NNP cord-005453-4057qib7 3587 35 ) ) -RRB- cord-005453-4057qib7 3587 36 reactivations reactivation NNS cord-005453-4057qib7 3587 37 , , , cord-005453-4057qib7 3587 38 count count NN cord-005453-4057qib7 3587 39 of of IN cord-005453-4057qib7 3587 40 CD34 CD34 NNP cord-005453-4057qib7 3587 41 + + CC cord-005453-4057qib7 3587 42 cells cell NNS cord-005453-4057qib7 3587 43 transfused transfuse VBN cord-005453-4057qib7 3587 44 , , , cord-005453-4057qib7 3587 45 LDH LDH NNP cord-005453-4057qib7 3587 46 level level NN cord-005453-4057qib7 3587 47 , , , cord-005453-4057qib7 3587 48 shizocytes shizocyte NNS cord-005453-4057qib7 3587 49 and and CC cord-005453-4057qib7 3587 50 creatinine creatinine NN cord-005453-4057qib7 3587 51 in in IN cord-005453-4057qib7 3587 52 the the DT cord-005453-4057qib7 3587 53 debut debut NN cord-005453-4057qib7 3587 54 of of IN cord-005453-4057qib7 3587 55 TA TA NNP cord-005453-4057qib7 3587 56 - - HYPH cord-005453-4057qib7 3587 57 TMA TMA NNP cord-005453-4057qib7 3587 58 . . . cord-005453-4057qib7 3588 1 In in IN cord-005453-4057qib7 3588 2 the the DT cord-005453-4057qib7 3588 3 multivariate multivariate JJ cord-005453-4057qib7 3588 4 analysis analysis NN cord-005453-4057qib7 3588 5 replacement replacement NN cord-005453-4057qib7 3588 6 of of IN cord-005453-4057qib7 3588 7 CNIs cni NNS cord-005453-4057qib7 3588 8 with with IN cord-005453-4057qib7 3588 9 Sir Sir NNP cord-005453-4057qib7 3588 10 ( ( -LRB- cord-005453-4057qib7 3588 11 HR HR NNP cord-005453-4057qib7 3588 12 0.27 0.27 CD cord-005453-4057qib7 3588 13 , , , cord-005453-4057qib7 3588 14 95%CI 95%ci CD cord-005453-4057qib7 3588 15 0.08 0.08 CD cord-005453-4057qib7 3588 16 - - HYPH cord-005453-4057qib7 3588 17 0.96 0.96 CD cord-005453-4057qib7 3588 18 , , , cord-005453-4057qib7 3588 19 p=0.018 p=0.018 NNP cord-005453-4057qib7 3588 20 ) ) -RRB- cord-005453-4057qib7 3588 21 and and CC cord-005453-4057qib7 3588 22 baseline baseline JJ cord-005453-4057qib7 3588 23 LDH LDH NNP cord-005453-4057qib7 3588 24 level level NN cord-005453-4057qib7 3588 25 ( ( -LRB- cord-005453-4057qib7 3588 26 HR HR NNP cord-005453-4057qib7 3588 27 1.01 1.01 CD cord-005453-4057qib7 3588 28 , , , cord-005453-4057qib7 3588 29 95%HR 95%hr CD cord-005453-4057qib7 3588 30 1.00 1.00 CD cord-005453-4057qib7 3588 31 - - SYM cord-005453-4057qib7 3588 32 1.01 1.01 CD cord-005453-4057qib7 3588 33 , , , cord-005453-4057qib7 3588 34 p=0.029 p=0.029 NNP cord-005453-4057qib7 3588 35 ) ) -RRB- cord-005453-4057qib7 3588 36 were be VBD cord-005453-4057qib7 3588 37 associated associate VBN cord-005453-4057qib7 3588 38 with with IN cord-005453-4057qib7 3588 39 survival survival NN cord-005453-4057qib7 3588 40 differences difference NNS cord-005453-4057qib7 3588 41 . . . cord-005453-4057qib7 3589 1 The the DT cord-005453-4057qib7 3589 2 cut cut NN cord-005453-4057qib7 3589 3 off off RP cord-005453-4057qib7 3589 4 for for IN cord-005453-4057qib7 3589 5 LDH LDH NNP cord-005453-4057qib7 3589 6 was be VBD cord-005453-4057qib7 3589 7 4xUNL 4xunl CD cord-005453-4057qib7 3589 8 . . . cord-005453-4057qib7 3590 1 aGVHD aGVHD NNP cord-005453-4057qib7 3590 2 grade grade NN cord-005453-4057qib7 3590 3 2 2 CD cord-005453-4057qib7 3590 4 - - SYM cord-005453-4057qib7 3590 5 4 4 CD cord-005453-4057qib7 3590 6 ( ( -LRB- cord-005453-4057qib7 3590 7 HR HR NNP cord-005453-4057qib7 3590 8 1.96 1.96 CD cord-005453-4057qib7 3590 9 , , , cord-005453-4057qib7 3590 10 p=0 p=0 NNP cord-005453-4057qib7 3590 11 , , , cord-005453-4057qib7 3590 12 081 081 CD cord-005453-4057qib7 3590 13 ) ) -RRB- cord-005453-4057qib7 3590 14 and and CC cord-005453-4057qib7 3590 15 use use NN cord-005453-4057qib7 3590 16 of of IN cord-005453-4057qib7 3590 17 PTCy PTCy NNS cord-005453-4057qib7 3590 18 ( ( -LRB- cord-005453-4057qib7 3590 19 HR hr NN cord-005453-4057qib7 3590 20 0.535 0.535 CD cord-005453-4057qib7 3590 21 , , , cord-005453-4057qib7 3590 22 p=0.317 p=0.317 NNP cord-005453-4057qib7 3590 23 ) ) -RRB- cord-005453-4057qib7 3590 24 were be VBD cord-005453-4057qib7 3590 25 not not RB cord-005453-4057qib7 3590 26 significant significant JJ cord-005453-4057qib7 3590 27 in in IN cord-005453-4057qib7 3590 28 the the DT cord-005453-4057qib7 3590 29 multivariate multivariate JJ cord-005453-4057qib7 3590 30 analysis analysis NN cord-005453-4057qib7 3590 31 ( ( -LRB- cord-005453-4057qib7 3590 32 figure figure NN cord-005453-4057qib7 3590 33 1 1 CD cord-005453-4057qib7 3590 34 ) ) -RRB- cord-005453-4057qib7 3590 35 . . . cord-005453-4057qib7 3591 1 TA TA NNP cord-005453-4057qib7 3591 2 - - HYPH cord-005453-4057qib7 3591 3 TMA TMA NNP cord-005453-4057qib7 3591 4 cases case NNS cord-005453-4057qib7 3591 5 after after IN cord-005453-4057qib7 3591 6 PTCy PTCy NNS cord-005453-4057qib7 3591 7 were be VBD cord-005453-4057qib7 3591 8 significantly significantly RB cord-005453-4057qib7 3591 9 less less RBR cord-005453-4057qib7 3591 10 frequently frequently RB cord-005453-4057qib7 3591 11 associated associate VBN cord-005453-4057qib7 3591 12 with with IN cord-005453-4057qib7 3591 13 clinically clinically RB cord-005453-4057qib7 3591 14 significant significant JJ cord-005453-4057qib7 3591 15 aGVHD agvhd NN cord-005453-4057qib7 3591 16 ( ( -LRB- cord-005453-4057qib7 3591 17 19 19 CD cord-005453-4057qib7 3591 18 % % NN cord-005453-4057qib7 3591 19 vs vs IN cord-005453-4057qib7 3591 20 68 68 CD cord-005453-4057qib7 3591 21 % % NN cord-005453-4057qib7 3591 22 , , , cord-005453-4057qib7 3591 23 p p NN cord-005453-4057qib7 3591 24 < < XX cord-005453-4057qib7 3591 25 0,001 0,001 CD cord-005453-4057qib7 3591 26 ) ) -RRB- cord-005453-4057qib7 3591 27 . . . cord-005453-4057qib7 3592 1 The the DT cord-005453-4057qib7 3592 2 survival survival NN cord-005453-4057qib7 3592 3 was be VBD cord-005453-4057qib7 3592 4 higher high JJR cord-005453-4057qib7 3592 5 after after IN cord-005453-4057qib7 3592 6 PTCy PTCy NNS cord-005453-4057qib7 3592 7 ( ( -LRB- cord-005453-4057qib7 3592 8 74 74 CD cord-005453-4057qib7 3592 9 % % NN cord-005453-4057qib7 3592 10 vs vs IN cord-005453-4057qib7 3592 11 15 15 CD cord-005453-4057qib7 3592 12 % % NN cord-005453-4057qib7 3592 13 ) ) -RRB- cord-005453-4057qib7 3592 14 , , , cord-005453-4057qib7 3592 15 but but CC cord-005453-4057qib7 3592 16 not not RB cord-005453-4057qib7 3592 17 significant significant JJ cord-005453-4057qib7 3592 18 due due IN cord-005453-4057qib7 3592 19 to to IN cord-005453-4057qib7 3592 20 sample sample NN cord-005453-4057qib7 3592 21 size size NN cord-005453-4057qib7 3592 22 and and CC cord-005453-4057qib7 3592 23 other other JJ cord-005453-4057qib7 3592 24 TA TA NNP cord-005453-4057qib7 3592 25 - - HYPH cord-005453-4057qib7 3592 26 TMA TMA NNP cord-005453-4057qib7 3592 27 factors factor NNS cord-005453-4057qib7 3592 28 . . . cord-005453-4057qib7 3593 1 Leading lead VBG cord-005453-4057qib7 3593 2 causes cause NNS cord-005453-4057qib7 3593 3 of of IN cord-005453-4057qib7 3593 4 death death NN cord-005453-4057qib7 3593 5 were be VBD cord-005453-4057qib7 3593 6 : : : cord-005453-4057qib7 3593 7 GVHD gvhd JJ cord-005453-4057qib7 3593 8 progression progression NN cord-005453-4057qib7 3593 9 ( ( -LRB- cord-005453-4057qib7 3593 10 11 11 CD cord-005453-4057qib7 3593 11 % % NN cord-005453-4057qib7 3593 12 ) ) -RRB- cord-005453-4057qib7 3593 13 , , , cord-005453-4057qib7 3593 14 bacterial bacterial JJ cord-005453-4057qib7 3593 15 infection infection NN cord-005453-4057qib7 3593 16 ( ( -LRB- cord-005453-4057qib7 3593 17 11 11 CD cord-005453-4057qib7 3593 18 % % NN cord-005453-4057qib7 3593 19 ) ) -RRB- cord-005453-4057qib7 3593 20 , , , cord-005453-4057qib7 3593 21 TMA TMA NNP cord-005453-4057qib7 3593 22 ( ( -LRB- cord-005453-4057qib7 3593 23 17 17 CD cord-005453-4057qib7 3593 24 % % NN cord-005453-4057qib7 3593 25 ) ) -RRB- cord-005453-4057qib7 3593 26 and and CC cord-005453-4057qib7 3593 27 other other JJ cord-005453-4057qib7 3593 28 ( ( -LRB- cord-005453-4057qib7 3593 29 19 19 CD cord-005453-4057qib7 3593 30 % % NN cord-005453-4057qib7 3593 31 ) ) -RRB- cord-005453-4057qib7 3593 32 . . . cord-005453-4057qib7 3594 1 Conclusions conclusion NNS cord-005453-4057qib7 3594 2 : : : cord-005453-4057qib7 3595 1 Replacing replace VBG cord-005453-4057qib7 3595 2 Tac Tac NNP cord-005453-4057qib7 3595 3 by by IN cord-005453-4057qib7 3595 4 Sir Sir NNP cord-005453-4057qib7 3595 5 is be VBZ cord-005453-4057qib7 3595 6 an an DT cord-005453-4057qib7 3595 7 effective effective JJ cord-005453-4057qib7 3595 8 therapeutic therapeutic JJ cord-005453-4057qib7 3595 9 strategy strategy NN cord-005453-4057qib7 3595 10 in in IN cord-005453-4057qib7 3595 11 a a DT cord-005453-4057qib7 3595 12 group group NN cord-005453-4057qib7 3595 13 of of IN cord-005453-4057qib7 3595 14 patients patient NNS cord-005453-4057qib7 3595 15 with with IN cord-005453-4057qib7 3595 16 debut debut NN cord-005453-4057qib7 3595 17 of of IN cord-005453-4057qib7 3595 18 TA TA NNP cord-005453-4057qib7 3595 19 - - HYPH cord-005453-4057qib7 3595 20 TMA TMA NNP cord-005453-4057qib7 3595 21 at at IN cord-005453-4057qib7 3595 22 least least JJS cord-005453-4057qib7 3595 23 after after IN cord-005453-4057qib7 3595 24 PTCy PTCy NNS cord-005453-4057qib7 3595 25 , , , cord-005453-4057qib7 3595 26 where where WRB cord-005453-4057qib7 3595 27 it -PRON- PRP cord-005453-4057qib7 3595 28 is be VBZ cord-005453-4057qib7 3595 29 less less RBR cord-005453-4057qib7 3595 30 likely likely JJ cord-005453-4057qib7 3595 31 to to TO cord-005453-4057qib7 3595 32 be be VB cord-005453-4057qib7 3595 33 associated associate VBN cord-005453-4057qib7 3595 34 with with IN cord-005453-4057qib7 3595 35 aGVHD aGVHD NNP cord-005453-4057qib7 3595 36 . . . cord-005453-4057qib7 3596 1 There there EX cord-005453-4057qib7 3596 2 is be VBZ cord-005453-4057qib7 3596 3 a a DT cord-005453-4057qib7 3596 4 significant significant JJ cord-005453-4057qib7 3596 5 overlap overlap NN cord-005453-4057qib7 3596 6 of of IN cord-005453-4057qib7 3596 7 populations population NNS cord-005453-4057qib7 3596 8 with with IN cord-005453-4057qib7 3596 9 PTCy PTCy NNS cord-005453-4057qib7 3596 10 prophylaxis prophylaxis NN cord-005453-4057qib7 3596 11 and and CC cord-005453-4057qib7 3596 12 substitution substitution NN cord-005453-4057qib7 3596 13 with with IN cord-005453-4057qib7 3596 14 Sir Sir NNP cord-005453-4057qib7 3596 15 , , , cord-005453-4057qib7 3596 16 thus thus RB cord-005453-4057qib7 3596 17 the the DT cord-005453-4057qib7 3596 18 study study NN cord-005453-4057qib7 3596 19 is be VBZ cord-005453-4057qib7 3596 20 not not RB cord-005453-4057qib7 3596 21 powered power VBN cord-005453-4057qib7 3596 22 to to TO cord-005453-4057qib7 3596 23 provide provide VB cord-005453-4057qib7 3596 24 guidance guidance NN cord-005453-4057qib7 3596 25 for for IN cord-005453-4057qib7 3596 26 patients patient NNS cord-005453-4057qib7 3596 27 on on IN cord-005453-4057qib7 3596 28 conventional conventional JJ cord-005453-4057qib7 3596 29 prophylaxis prophylaxis NN cord-005453-4057qib7 3596 30 with with IN cord-005453-4057qib7 3596 31 TA TA NNP cord-005453-4057qib7 3596 32 - - HYPH cord-005453-4057qib7 3596 33 TMA TMA NNP cord-005453-4057qib7 3596 34 . . . cord-005453-4057qib7 3597 1 [ [ -LRB- cord-005453-4057qib7 3597 2 [ [ -LRB- cord-005453-4057qib7 3597 3 P172 P172 NNP cord-005453-4057qib7 3597 4 Image image NN cord-005453-4057qib7 3597 5 ] ] -RRB- cord-005453-4057qib7 3597 6 1 1 CD cord-005453-4057qib7 3597 7 . . . cord-005453-4057qib7 3598 1 Disclosure disclosure NN cord-005453-4057qib7 3598 2 : : : cord-005453-4057qib7 3598 3 None none NN cord-005453-4057qib7 3598 4 of of IN cord-005453-4057qib7 3598 5 the the DT cord-005453-4057qib7 3598 6 authors author NNS cord-005453-4057qib7 3598 7 has have VBZ cord-005453-4057qib7 3598 8 anything anything NN cord-005453-4057qib7 3598 9 to to TO cord-005453-4057qib7 3598 10 disclose disclose VB cord-005453-4057qib7 3598 11 . . . cord-005453-4057qib7 3599 1 Donor donor NN cord-005453-4057qib7 3599 2 - - HYPH cord-005453-4057qib7 3599 3 recipient recipient NN cord-005453-4057qib7 3599 4 AB0 ab0 NN cord-005453-4057qib7 3599 5 mismatch mismatch NN cord-005453-4057qib7 3599 6 effect effect NN cord-005453-4057qib7 3599 7 on on IN cord-005453-4057qib7 3599 8 the the DT cord-005453-4057qib7 3599 9 allogeneic allogeneic NN cord-005453-4057qib7 3599 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 3599 11 stem stem NN cord-005453-4057qib7 3599 12 cell cell NN cord-005453-4057qib7 3599 13 transplantation transplantation NN cord-005453-4057qib7 3599 14 outcome outcome NN cord-005453-4057qib7 3599 15 : : : cord-005453-4057qib7 3600 1 A a DT cord-005453-4057qib7 3600 2 single single JJ cord-005453-4057qib7 3600 3 - - HYPH cord-005453-4057qib7 3600 4 center center NN cord-005453-4057qib7 3600 5 retrospective retrospective JJ cord-005453-4057qib7 3600 6 study study NN cord-005453-4057qib7 3600 7 Background background NN cord-005453-4057qib7 3600 8 : : : cord-005453-4057qib7 3601 1 Because because IN cord-005453-4057qib7 3601 2 transmission transmission NN cord-005453-4057qib7 3601 3 of of IN cord-005453-4057qib7 3601 4 major major JJ cord-005453-4057qib7 3601 5 histocompatibility histocompatibility NN cord-005453-4057qib7 3601 6 complex complex NN cord-005453-4057qib7 3601 7 and and CC cord-005453-4057qib7 3601 8 blood blood NN cord-005453-4057qib7 3601 9 group group NN cord-005453-4057qib7 3601 10 system system NN cord-005453-4057qib7 3601 11 genes gene NNS cord-005453-4057qib7 3601 12 is be VBZ cord-005453-4057qib7 3601 13 independent independent JJ cord-005453-4057qib7 3601 14 from from IN cord-005453-4057qib7 3601 15 each each DT cord-005453-4057qib7 3601 16 other other JJ cord-005453-4057qib7 3601 17 , , , cord-005453-4057qib7 3601 18 approximately approximately RB cord-005453-4057qib7 3601 19 40 40 CD cord-005453-4057qib7 3601 20 - - SYM cord-005453-4057qib7 3601 21 50 50 CD cord-005453-4057qib7 3601 22 % % NN cord-005453-4057qib7 3601 23 of of IN cord-005453-4057qib7 3601 24 all all DT cord-005453-4057qib7 3601 25 allogeneic allogeneic JJ cord-005453-4057qib7 3601 26 hematopoietic hematopoietic JJ cord-005453-4057qib7 3601 27 stem stem NN cord-005453-4057qib7 3601 28 cell cell NN cord-005453-4057qib7 3601 29 transplantations transplantation NNS cord-005453-4057qib7 3601 30 ( ( -LRB- cord-005453-4057qib7 3601 31 allo allo NN cord-005453-4057qib7 3601 32 - - HYPH cord-005453-4057qib7 3601 33 HSCT HSCT NNP cord-005453-4057qib7 3601 34 ) ) -RRB- cord-005453-4057qib7 3601 35 are be VBP cord-005453-4057qib7 3601 36 realized realize VBN cord-005453-4057qib7 3601 37 crosswise crosswise IN cord-005453-4057qib7 3601 38 the the DT cord-005453-4057qib7 3601 39 AB0-blood ab0-blood NN cord-005453-4057qib7 3601 40 group group NN cord-005453-4057qib7 3601 41 boundary boundary NN cord-005453-4057qib7 3601 42 . . . cord-005453-4057qib7 3602 1 However however RB cord-005453-4057qib7 3602 2 , , , cord-005453-4057qib7 3602 3 due due IN cord-005453-4057qib7 3602 4 to to IN cord-005453-4057qib7 3602 5 the the DT cord-005453-4057qib7 3602 6 widespread widespread JJ cord-005453-4057qib7 3602 7 expression expression NN cord-005453-4057qib7 3602 8 of of IN cord-005453-4057qib7 3602 9 AB0 AB0 NNP cord-005453-4057qib7 3602 10 antigens antigen NNS cord-005453-4057qib7 3602 11 on on IN cord-005453-4057qib7 3602 12 a a DT cord-005453-4057qib7 3602 13 variety variety NN cord-005453-4057qib7 3602 14 of of IN cord-005453-4057qib7 3602 15 human human JJ cord-005453-4057qib7 3602 16 tissues tissue NNS cord-005453-4057qib7 3602 17 other other JJ cord-005453-4057qib7 3602 18 than than IN cord-005453-4057qib7 3602 19 erythrocytes erythrocyte NNS cord-005453-4057qib7 3602 20 , , , cord-005453-4057qib7 3602 21 AB0 ab0 NN cord-005453-4057qib7 3602 22 incompatibility incompatibility NN cord-005453-4057qib7 3602 23 may may MD cord-005453-4057qib7 3602 24 have have VB cord-005453-4057qib7 3602 25 an an DT cord-005453-4057qib7 3602 26 impact impact NN cord-005453-4057qib7 3602 27 on on IN cord-005453-4057qib7 3602 28 the the DT cord-005453-4057qib7 3602 29 outcome outcome NN cord-005453-4057qib7 3602 30 of of IN cord-005453-4057qib7 3602 31 allogeneic allogeneic NN cord-005453-4057qib7 3602 32 HSCT HSCT NNP cord-005453-4057qib7 3602 33 that that WDT cord-005453-4057qib7 3602 34 goes go VBZ cord-005453-4057qib7 3602 35 beyond beyond IN cord-005453-4057qib7 3602 36 the the DT cord-005453-4057qib7 3602 37 wellknown wellknown JJ cord-005453-4057qib7 3602 38 immune immune JJ cord-005453-4057qib7 3602 39 - - HYPH cord-005453-4057qib7 3602 40 hematological hematological JJ cord-005453-4057qib7 3602 41 complications complication NNS cord-005453-4057qib7 3602 42 such such JJ cord-005453-4057qib7 3602 43 as as IN cord-005453-4057qib7 3602 44 immediate immediate JJ cord-005453-4057qib7 3602 45 hemolysis hemolysis NN cord-005453-4057qib7 3602 46 due due IN cord-005453-4057qib7 3602 47 to to IN cord-005453-4057qib7 3602 48 the the DT cord-005453-4057qib7 3602 49 presence presence NN cord-005453-4057qib7 3602 50 of of IN cord-005453-4057qib7 3602 51 isoagglutinins isoagglutinin NNS cord-005453-4057qib7 3602 52 and and CC cord-005453-4057qib7 3602 53 delayed delay VBN cord-005453-4057qib7 3602 54 hemolysis hemolysis NN cord-005453-4057qib7 3602 55 due due IN cord-005453-4057qib7 3602 56 to to IN cord-005453-4057qib7 3602 57 passenger passenger NN cord-005453-4057qib7 3602 58 B b NN cord-005453-4057qib7 3602 59 lymphocytes lymphocyte NNS cord-005453-4057qib7 3602 60 . . . cord-005453-4057qib7 3603 1 Here here RB cord-005453-4057qib7 3603 2 we -PRON- PRP cord-005453-4057qib7 3603 3 aimed aim VBD cord-005453-4057qib7 3603 4 to to TO cord-005453-4057qib7 3603 5 assess assess VB cord-005453-4057qib7 3603 6 the the DT cord-005453-4057qib7 3603 7 donor donor NN cord-005453-4057qib7 3603 8 - - HYPH cord-005453-4057qib7 3603 9 recipient recipient NN cord-005453-4057qib7 3603 10 AB0 ab0 NN cord-005453-4057qib7 3603 11 mismatch mismatch NN cord-005453-4057qib7 3603 12 effect effect NN cord-005453-4057qib7 3603 13 on on IN cord-005453-4057qib7 3603 14 the the DT cord-005453-4057qib7 3603 15 allo allo NN cord-005453-4057qib7 3603 16 - - HYPH cord-005453-4057qib7 3603 17 HSCT HSCT NNP cord-005453-4057qib7 3603 18 outcome outcome NN cord-005453-4057qib7 3603 19 , , , cord-005453-4057qib7 3603 20 comprising comprise VBG cord-005453-4057qib7 3603 21 non non JJ cord-005453-4057qib7 3603 22 - - JJ cord-005453-4057qib7 3603 23 relapse relapse JJ cord-005453-4057qib7 3603 24 mortality mortality NN cord-005453-4057qib7 3603 25 ( ( -LRB- cord-005453-4057qib7 3603 26 NRM NRM NNP cord-005453-4057qib7 3603 27 ) ) -RRB- cord-005453-4057qib7 3603 28 , , , cord-005453-4057qib7 3603 29 overall overall JJ cord-005453-4057qib7 3603 30 and and CC cord-005453-4057qib7 3603 31 relapse relapse NN cord-005453-4057qib7 3603 32 - - HYPH cord-005453-4057qib7 3603 33 free free JJ cord-005453-4057qib7 3603 34 survival survival NN cord-005453-4057qib7 3603 35 , , , cord-005453-4057qib7 3603 36 posttransplant posttransplant NN cord-005453-4057qib7 3603 37 PRC PRC NNP cord-005453-4057qib7 3603 38 transfusion transfusion NN cord-005453-4057qib7 3603 39 requirement requirement NN cord-005453-4057qib7 3603 40 , , , cord-005453-4057qib7 3603 41 as as RB cord-005453-4057qib7 3603 42 well well RB cord-005453-4057qib7 3603 43 as as IN cord-005453-4057qib7 3603 44 relapse relapse NN cord-005453-4057qib7 3603 45 rate rate NN cord-005453-4057qib7 3603 46 , , , cord-005453-4057qib7 3603 47 incidence incidence NN cord-005453-4057qib7 3603 48 of of IN cord-005453-4057qib7 3603 49 graft graft NN cord-005453-4057qib7 3603 50 - - HYPH cord-005453-4057qib7 3603 51 failure failure NN cord-005453-4057qib7 3603 52 and and CC cord-005453-4057qib7 3603 53 acute acute JJ cord-005453-4057qib7 3603 54 GvHD gvhd NN cord-005453-4057qib7 3603 55 . . . cord-005453-4057qib7 3604 1 Methods method NNS cord-005453-4057qib7 3604 2 : : : cord-005453-4057qib7 3605 1 Clinical clinical JJ cord-005453-4057qib7 3605 2 and and CC cord-005453-4057qib7 3605 3 laboratory laboratory NN cord-005453-4057qib7 3605 4 data datum NNS cord-005453-4057qib7 3605 5 from from IN cord-005453-4057qib7 3605 6 180 180 CD cord-005453-4057qib7 3605 7 consecutive consecutive JJ cord-005453-4057qib7 3605 8 patients patient NNS cord-005453-4057qib7 3605 9 undergoing undergo VBG cord-005453-4057qib7 3605 10 allogeneic allogeneic IN cord-005453-4057qib7 3605 11 HSCT HSCT NNP cord-005453-4057qib7 3605 12 between between IN cord-005453-4057qib7 3605 13 01/2008 01/2008 CD cord-005453-4057qib7 3605 14 and and CC cord-005453-4057qib7 3605 15 06/2018 06/2018 CD cord-005453-4057qib7 3605 16 at at IN cord-005453-4057qib7 3605 17 the the DT cord-005453-4057qib7 3605 18 Fondazione Fondazione NNP cord-005453-4057qib7 3605 19 IRCCS IRCCS NNP cord-005453-4057qib7 3606 1 Ca ca RB cord-005453-4057qib7 3606 2 ' ' '' cord-005453-4057qib7 3606 3 Granda Granda NNP cord-005453-4057qib7 3606 4 Maggiore Maggiore NNP cord-005453-4057qib7 3606 5 Policlinico Policlinico NNP cord-005453-4057qib7 3606 6 Hospital Hospital NNP cord-005453-4057qib7 3606 7 in in IN cord-005453-4057qib7 3606 8 Milan Milan NNP cord-005453-4057qib7 3606 9 , , , cord-005453-4057qib7 3606 10 Italy Italy NNP cord-005453-4057qib7 3606 11 , , , cord-005453-4057qib7 3606 12 were be VBD cord-005453-4057qib7 3606 13 retrospectively retrospectively RB cord-005453-4057qib7 3606 14 collected collect VBN cord-005453-4057qib7 3606 15 . . . cord-005453-4057qib7 3607 1 Kaplan Kaplan NNP cord-005453-4057qib7 3607 2 Meier Meier NNP cord-005453-4057qib7 3607 3 estimates estimate NNS cord-005453-4057qib7 3607 4 were be VBD cord-005453-4057qib7 3607 5 used use VBN cord-005453-4057qib7 3607 6 for for IN cord-005453-4057qib7 3607 7 the the DT cord-005453-4057qib7 3607 8 analysis analysis NN cord-005453-4057qib7 3607 9 of of IN cord-005453-4057qib7 3607 10 survival survival NN cord-005453-4057qib7 3607 11 outcomes outcome NNS cord-005453-4057qib7 3607 12 while while IN cord-005453-4057qib7 3607 13 NRM NRM NNP cord-005453-4057qib7 3607 14 , , , cord-005453-4057qib7 3607 15 relapse relapse NN cord-005453-4057qib7 3607 16 and and CC cord-005453-4057qib7 3607 17 acute acute JJ cord-005453-4057qib7 3607 18 GvHD GvHD NNP cord-005453-4057qib7 3607 19 cumulative cumulative JJ cord-005453-4057qib7 3607 20 incidences incidence NNS cord-005453-4057qib7 3607 21 were be VBD cord-005453-4057qib7 3607 22 investigated investigate VBN cord-005453-4057qib7 3607 23 by by IN cord-005453-4057qib7 3607 24 competing compete VBG cord-005453-4057qib7 3607 25 risk risk NN cord-005453-4057qib7 3607 26 analysis analysis NN cord-005453-4057qib7 3607 27 . . . cord-005453-4057qib7 3608 1 Results result NNS cord-005453-4057qib7 3608 2 : : : cord-005453-4057qib7 3609 1 The the DT cord-005453-4057qib7 3609 2 patient patient JJ cord-005453-4057qib7 3609 3 series series NN cord-005453-4057qib7 3609 4 included include VBD cord-005453-4057qib7 3609 5 105 105 CD cord-005453-4057qib7 3609 6 AB0-match ab0-match NN cord-005453-4057qib7 3609 7 , , , cord-005453-4057qib7 3609 8 31 31 CD cord-005453-4057qib7 3609 9 major major JJ cord-005453-4057qib7 3609 10 AB0-mismatch ab0-mismatch NN cord-005453-4057qib7 3609 11 , , , cord-005453-4057qib7 3609 12 34 34 CD cord-005453-4057qib7 3609 13 minor minor JJ cord-005453-4057qib7 3609 14 AB0-mismatched ab0-mismatche VBN cord-005453-4057qib7 3609 15 and and CC cord-005453-4057qib7 3609 16 10 10 CD cord-005453-4057qib7 3609 17 bidirectionally bidirectionally RB cord-005453-4057qib7 3609 18 AB0-mismatch ab0-mismatch JJ cord-005453-4057qib7 3609 19 transplants transplant NNS cord-005453-4057qib7 3609 20 . . . cord-005453-4057qib7 3610 1 Indication indication NN cord-005453-4057qib7 3610 2 for for IN cord-005453-4057qib7 3610 3 allo allo NN cord-005453-4057qib7 3610 4 - - HYPH cord-005453-4057qib7 3610 5 HSCT HSCT NNP cord-005453-4057qib7 3610 6 were be VBD cord-005453-4057qib7 3610 7 mainly mainly RB cord-005453-4057qib7 3610 8 AML AML NNP cord-005453-4057qib7 3610 9 / / SYM cord-005453-4057qib7 3610 10 MDS MDS NNP cord-005453-4057qib7 3610 11 ( ( -LRB- cord-005453-4057qib7 3610 12 77 77 CD cord-005453-4057qib7 3610 13 pts pts CD cord-005453-4057qib7 3610 14 ) ) -RRB- cord-005453-4057qib7 3610 15 , , , cord-005453-4057qib7 3610 16 ALL all DT cord-005453-4057qib7 3610 17 ( ( -LRB- cord-005453-4057qib7 3610 18 34 34 CD cord-005453-4057qib7 3610 19 pts pts CD cord-005453-4057qib7 3610 20 ) ) -RRB- cord-005453-4057qib7 3610 21 and and CC cord-005453-4057qib7 3610 22 T T NNP cord-005453-4057qib7 3610 23 - - HYPH cord-005453-4057qib7 3610 24 NHL NHL NNP cord-005453-4057qib7 3610 25 / / SYM cord-005453-4057qib7 3610 26 CTCL CTCL NNP cord-005453-4057qib7 3610 27 ( ( -LRB- cord-005453-4057qib7 3610 28 32 32 CD cord-005453-4057qib7 3610 29 pts pts NN cord-005453-4057qib7 3610 30 ) ) -RRB- cord-005453-4057qib7 3610 31 . . . cord-005453-4057qib7 3611 1 Mean mean JJ cord-005453-4057qib7 3611 2 overall overall JJ cord-005453-4057qib7 3611 3 survival survival NN cord-005453-4057qib7 3611 4 for for IN cord-005453-4057qib7 3611 5 groups group NNS cord-005453-4057qib7 3611 6 of of IN cord-005453-4057qib7 3611 7 patients patient NNS cord-005453-4057qib7 3611 8 undergoing undergo VBG cord-005453-4057qib7 3611 9 AB0-identical ab0-identical JJ cord-005453-4057qib7 3611 10 , , , cord-005453-4057qib7 3611 11 major major JJ cord-005453-4057qib7 3611 12 AB0 ab0 NN cord-005453-4057qib7 3611 13 mismatch mismatch NN cord-005453-4057qib7 3611 14 and and CC cord-005453-4057qib7 3611 15 minor minor JJ cord-005453-4057qib7 3611 16 AB0 ab0 NN cord-005453-4057qib7 3611 17 mismatch mismatch NN cord-005453-4057qib7 3612 1 HSCT HSCT NNP cord-005453-4057qib7 3612 2 were be VBD cord-005453-4057qib7 3612 3 66 66 CD cord-005453-4057qib7 3612 4 months month NNS cord-005453-4057qib7 3613 1 ( ( -LRB- cord-005453-4057qib7 3613 2 95 95 CD cord-005453-4057qib7 3613 3 % % NN cord-005453-4057qib7 3613 4 CI CI NNP cord-005453-4057qib7 3613 5 [ [ -LRB- cord-005453-4057qib7 3613 6 55 55 CD cord-005453-4057qib7 3613 7 ; ; : cord-005453-4057qib7 3613 8 77 77 CD cord-005453-4057qib7 3613 9 ] ] -RRB- cord-005453-4057qib7 3613 10 ) ) -RRB- cord-005453-4057qib7 3613 11 , , , cord-005453-4057qib7 3613 12 47 47 CD cord-005453-4057qib7 3613 13 months month NNS cord-005453-4057qib7 3613 14 ( ( -LRB- cord-005453-4057qib7 3613 15 95 95 CD cord-005453-4057qib7 3613 16 % % NN cord-005453-4057qib7 3613 17 CI CI NNP cord-005453-4057qib7 3613 18 [ [ -LRB- cord-005453-4057qib7 3613 19 28 28 CD cord-005453-4057qib7 3613 20 ; ; : cord-005453-4057qib7 3613 21 65 65 CD cord-005453-4057qib7 3613 22 ) ) -RRB- cord-005453-4057qib7 3613 23 and and CC cord-005453-4057qib7 3613 24 46 46 CD cord-005453-4057qib7 3613 25 months month NNS cord-005453-4057qib7 3614 1 ( ( -LRB- cord-005453-4057qib7 3614 2 95 95 CD cord-005453-4057qib7 3614 3 % % NN cord-005453-4057qib7 3614 4 CI CI NNP cord-005453-4057qib7 3614 5 [ [ -LRB- cord-005453-4057qib7 3614 6 31 31 CD cord-005453-4057qib7 3614 7 ; ; : cord-005453-4057qib7 3614 8 61 61 CD cord-005453-4057qib7 3614 9 ] ] -RRB- cord-005453-4057qib7 3614 10 ) ) -RRB- cord-005453-4057qib7 3614 11 , , , cord-005453-4057qib7 3614 12 respectively respectively RB cord-005453-4057qib7 3614 13 . . . cord-005453-4057qib7 3615 1 NRM NRM NNP cord-005453-4057qib7 3615 2 in in IN cord-005453-4057qib7 3615 3 the the DT cord-005453-4057qib7 3615 4 three three CD cord-005453-4057qib7 3615 5 groups group NNS cord-005453-4057qib7 3615 6 were be VBD cord-005453-4057qib7 3615 7 significantly significantly RB cord-005453-4057qib7 3615 8 different different JJ cord-005453-4057qib7 3615 9 , , , cord-005453-4057qib7 3615 10 with with IN cord-005453-4057qib7 3615 11 point point NN cord-005453-4057qib7 3615 12 estimates estimate NNS cord-005453-4057qib7 3615 13 of of IN cord-005453-4057qib7 3615 14 12 12 CD cord-005453-4057qib7 3615 15 % % NN cord-005453-4057qib7 3615 16 , , , cord-005453-4057qib7 3615 17 29 29 CD cord-005453-4057qib7 3615 18 % % NN cord-005453-4057qib7 3615 19 and and CC cord-005453-4057qib7 3615 20 26 26 CD cord-005453-4057qib7 3615 21 % % NN cord-005453-4057qib7 3615 22 at at IN cord-005453-4057qib7 3615 23 5 5 CD cord-005453-4057qib7 3615 24 years year NNS cord-005453-4057qib7 3615 25 , , , cord-005453-4057qib7 3615 26 respectively respectively RB cord-005453-4057qib7 3615 27 , , , cord-005453-4057qib7 3615 28 whereas whereas IN cord-005453-4057qib7 3615 29 no no DT cord-005453-4057qib7 3615 30 significant significant JJ cord-005453-4057qib7 3615 31 differences difference NNS cord-005453-4057qib7 3615 32 were be VBD cord-005453-4057qib7 3615 33 observed observe VBN cord-005453-4057qib7 3615 34 for for IN cord-005453-4057qib7 3615 35 relapse relapse NN cord-005453-4057qib7 3615 36 rate rate NN cord-005453-4057qib7 3615 37 and and CC cord-005453-4057qib7 3615 38 graft graft NN cord-005453-4057qib7 3615 39 failure failure NN cord-005453-4057qib7 3615 40 incidence incidence NN cord-005453-4057qib7 3615 41 . . . cord-005453-4057qib7 3616 1 Although although IN cord-005453-4057qib7 3616 2 not not RB cord-005453-4057qib7 3616 3 statistically statistically RB cord-005453-4057qib7 3616 4 different different JJ cord-005453-4057qib7 3616 5 , , , cord-005453-4057qib7 3616 6 incidence incidence NN cord-005453-4057qib7 3616 7 of of IN cord-005453-4057qib7 3616 8 acute acute JJ cord-005453-4057qib7 3616 9 grade grade NN cord-005453-4057qib7 3616 10 III III NNP cord-005453-4057qib7 3616 11 - - HYPH cord-005453-4057qib7 3616 12 IV IV NNP cord-005453-4057qib7 3616 13 GvHD GvHD NNP cord-005453-4057qib7 3616 14 was be VBD cord-005453-4057qib7 3616 15 twice twice RB cord-005453-4057qib7 3616 16 as as RB cord-005453-4057qib7 3616 17 high high JJ cord-005453-4057qib7 3616 18 in in IN cord-005453-4057qib7 3616 19 patients patient NNS cord-005453-4057qib7 3616 20 transplanted transplant VBN cord-005453-4057qib7 3616 21 from from IN cord-005453-4057qib7 3616 22 minor minor JJ cord-005453-4057qib7 3616 23 AB0mismatched AB0mismatched NNP cord-005453-4057qib7 3616 24 donors donor NNS cord-005453-4057qib7 3616 25 than than IN cord-005453-4057qib7 3616 26 in in IN cord-005453-4057qib7 3616 27 the the DT cord-005453-4057qib7 3616 28 AB0 AB0 NNP cord-005453-4057qib7 3616 29 identical identical JJ cord-005453-4057qib7 3616 30 group group NN cord-005453-4057qib7 3616 31 ( ( -LRB- cord-005453-4057qib7 3616 32 16 16 CD cord-005453-4057qib7 3616 33 % % NN cord-005453-4057qib7 3616 34 vs vs IN cord-005453-4057qib7 3616 35 8 8 CD cord-005453-4057qib7 3616 36 % % NN cord-005453-4057qib7 3616 37 ) ) -RRB- cord-005453-4057qib7 3616 38 . . . cord-005453-4057qib7 3617 1 Following follow VBG cord-005453-4057qib7 3617 2 transplantation transplantation NN cord-005453-4057qib7 3617 3 , , , cord-005453-4057qib7 3617 4 PRC PRC NNP cord-005453-4057qib7 3617 5 transfusion transfusion NN cord-005453-4057qib7 3617 6 requirement requirement NN cord-005453-4057qib7 3617 7 was be VBD cord-005453-4057qib7 3617 8 significantly significantly RB cord-005453-4057qib7 3617 9 higher high JJR cord-005453-4057qib7 3617 10 in in IN cord-005453-4057qib7 3617 11 the the DT cord-005453-4057qib7 3617 12 major major JJ cord-005453-4057qib7 3617 13 AB0 ab0 NN cord-005453-4057qib7 3617 14 mismatch mismatch NN cord-005453-4057qib7 3617 15 then then RB cord-005453-4057qib7 3617 16 in in IN cord-005453-4057qib7 3617 17 the the DT cord-005453-4057qib7 3617 18 AB0-match ab0-match NN cord-005453-4057qib7 3617 19 transplanted transplant VBN cord-005453-4057qib7 3617 20 patients patient NNS cord-005453-4057qib7 3617 21 ( ( -LRB- cord-005453-4057qib7 3617 22 median median NN cord-005453-4057qib7 3617 23 14 14 CD cord-005453-4057qib7 3617 24 vs vs IN cord-005453-4057qib7 3617 25 7 7 CD cord-005453-4057qib7 3617 26 , , , cord-005453-4057qib7 3617 27 p=0.01 p=0.01 NNP cord-005453-4057qib7 3617 28 ) ) -RRB- cord-005453-4057qib7 3617 29 , , , cord-005453-4057qib7 3617 30 with with IN cord-005453-4057qib7 3617 31 a a DT cord-005453-4057qib7 3617 32 marginal marginal JJ cord-005453-4057qib7 3617 33 positive positive JJ cord-005453-4057qib7 3617 34 correlation correlation NN cord-005453-4057qib7 3617 35 between between IN cord-005453-4057qib7 3617 36 the the DT cord-005453-4057qib7 3617 37 anti anti JJ cord-005453-4057qib7 3617 38 - - JJ cord-005453-4057qib7 3617 39 donor donor JJ cord-005453-4057qib7 3617 40 A a NN cord-005453-4057qib7 3617 41 / / SYM cord-005453-4057qib7 3617 42 B b NN cord-005453-4057qib7 3617 43 IgG igg NN cord-005453-4057qib7 3617 44 titers titer NNS cord-005453-4057qib7 3617 45 measured measure VBD cord-005453-4057qib7 3617 46 prior prior JJ cord-005453-4057qib7 3617 47 HSCT HSCT NNP cord-005453-4057qib7 3617 48 and and CC cord-005453-4057qib7 3617 49 the the DT cord-005453-4057qib7 3617 50 total total JJ cord-005453-4057qib7 3617 51 number number NN cord-005453-4057qib7 3617 52 of of IN cord-005453-4057qib7 3617 53 PRC PRC NNP cord-005453-4057qib7 3617 54 transfused transfuse VBN cord-005453-4057qib7 3617 55 during during IN cord-005453-4057qib7 3617 56 the the DT cord-005453-4057qib7 3617 57 first first JJ cord-005453-4057qib7 3617 58 year year NN cord-005453-4057qib7 3617 59 following follow VBG cord-005453-4057qib7 3617 60 transplantation transplantation NN cord-005453-4057qib7 3617 61 . . . cord-005453-4057qib7 3618 1 We -PRON- PRP cord-005453-4057qib7 3618 2 observed observe VBD cord-005453-4057qib7 3618 3 only only RB cord-005453-4057qib7 3618 4 one one CD cord-005453-4057qib7 3618 5 case case NN cord-005453-4057qib7 3618 6 of of IN cord-005453-4057qib7 3618 7 PRCA PRCA NNP cord-005453-4057qib7 3618 8 occurring occur VBG cord-005453-4057qib7 3618 9 in in IN cord-005453-4057qib7 3618 10 a a DT cord-005453-4057qib7 3618 11 50year 50year JJ cord-005453-4057qib7 3618 12 - - HYPH cord-005453-4057qib7 3618 13 old old JJ cord-005453-4057qib7 3618 14 0 0 CD cord-005453-4057qib7 3618 15 + + CC cord-005453-4057qib7 3618 16 woman woman NN cord-005453-4057qib7 3618 17 who who WP cord-005453-4057qib7 3618 18 was be VBD cord-005453-4057qib7 3618 19 transplanted transplant VBN cord-005453-4057qib7 3618 20 from from IN cord-005453-4057qib7 3618 21 a a DT cord-005453-4057qib7 3618 22 32-yearold 32-yearold CD cord-005453-4057qib7 3618 23 male male JJ cord-005453-4057qib7 3618 24 A+ a+ ADD cord-005453-4057qib7 3618 25 HLA HLA NNP cord-005453-4057qib7 3618 26 - - HYPH cord-005453-4057qib7 3618 27 identical identical JJ cord-005453-4057qib7 3618 28 sibling sibling NN cord-005453-4057qib7 3618 29 using use VBG cord-005453-4057qib7 3618 30 peripheral peripheral JJ cord-005453-4057qib7 3618 31 blood blood NN cord-005453-4057qib7 3618 32 as as IN cord-005453-4057qib7 3618 33 the the DT cord-005453-4057qib7 3618 34 stem stem NN cord-005453-4057qib7 3618 35 cell cell NN cord-005453-4057qib7 3618 36 source source NN cord-005453-4057qib7 3618 37 following follow VBG cord-005453-4057qib7 3618 38 a a DT cord-005453-4057qib7 3618 39 myeloablative myeloablative JJ cord-005453-4057qib7 3618 40 conditioning conditioning NN cord-005453-4057qib7 3618 41 for for IN cord-005453-4057qib7 3618 42 AML AML NNP cord-005453-4057qib7 3618 43 in in IN cord-005453-4057qib7 3618 44 first first JJ cord-005453-4057qib7 3618 45 complete complete JJ cord-005453-4057qib7 3618 46 remission remission NN cord-005453-4057qib7 3618 47 . . . cord-005453-4057qib7 3619 1 Anti anti JJ cord-005453-4057qib7 3619 2 - - JJ cord-005453-4057qib7 3619 3 A a DT cord-005453-4057qib7 3619 4 IgG igg NN cord-005453-4057qib7 3619 5 isoagglutinin isoagglutinin NNS cord-005453-4057qib7 3619 6 titers titer NNS cord-005453-4057qib7 3619 7 prior prior RB cord-005453-4057qib7 3619 8 to to IN cord-005453-4057qib7 3619 9 transplantation transplantation NN cord-005453-4057qib7 3619 10 were be VBD cord-005453-4057qib7 3619 11 1:256 1:256 CD cord-005453-4057qib7 3619 12 . . . cord-005453-4057qib7 3620 1 During during IN cord-005453-4057qib7 3620 2 the the DT cord-005453-4057qib7 3620 3 first first JJ cord-005453-4057qib7 3620 4 year year NN cord-005453-4057qib7 3620 5 post post NN cord-005453-4057qib7 3620 6 transplantation transplantation NN cord-005453-4057qib7 3620 7 , , , cord-005453-4057qib7 3620 8 the the DT cord-005453-4057qib7 3620 9 patient patient NN cord-005453-4057qib7 3620 10 required require VBD cord-005453-4057qib7 3620 11 a a DT cord-005453-4057qib7 3620 12 total total NN cord-005453-4057qib7 3620 13 of of IN cord-005453-4057qib7 3620 14 46 46 CD cord-005453-4057qib7 3620 15 PRC PRC NNP cord-005453-4057qib7 3620 16 transfusions transfusion NNS cord-005453-4057qib7 3620 17 , , , cord-005453-4057qib7 3620 18 with with IN cord-005453-4057qib7 3620 19 gradual gradual JJ cord-005453-4057qib7 3620 20 resolution resolution NN cord-005453-4057qib7 3620 21 occurring occur VBG cord-005453-4057qib7 3620 22 only only RB cord-005453-4057qib7 3620 23 after after IN cord-005453-4057qib7 3620 24 introduction introduction NN cord-005453-4057qib7 3620 25 of of IN cord-005453-4057qib7 3620 26 danazole danazole NNP cord-005453-4057qib7 3620 27 treatment treatment NN cord-005453-4057qib7 3620 28 . . . cord-005453-4057qib7 3621 1 Conclusions conclusion NNS cord-005453-4057qib7 3621 2 : : : cord-005453-4057qib7 3622 1 In in IN cord-005453-4057qib7 3622 2 our -PRON- PRP$ cord-005453-4057qib7 3622 3 patient patient JJ cord-005453-4057qib7 3622 4 cohort cohort NN cord-005453-4057qib7 3622 5 , , , cord-005453-4057qib7 3622 6 both both DT cord-005453-4057qib7 3622 7 major major JJ cord-005453-4057qib7 3622 8 and and CC cord-005453-4057qib7 3622 9 minor minor JJ cord-005453-4057qib7 3622 10 AB0 ab0 NN cord-005453-4057qib7 3622 11 mismatch mismatch NN cord-005453-4057qib7 3622 12 associated associate VBN cord-005453-4057qib7 3622 13 to to IN cord-005453-4057qib7 3622 14 a a DT cord-005453-4057qib7 3622 15 significantly significantly RB cord-005453-4057qib7 3622 16 higher high JJR cord-005453-4057qib7 3622 17 NRM NRM NNP cord-005453-4057qib7 3622 18 . . . cord-005453-4057qib7 3623 1 Major major JJ cord-005453-4057qib7 3623 2 AB0 ab0 NN cord-005453-4057qib7 3623 3 mismatch mismatch NN cord-005453-4057qib7 3623 4 associated associate VBN cord-005453-4057qib7 3623 5 to to IN cord-005453-4057qib7 3623 6 a a DT cord-005453-4057qib7 3623 7 higher high JJR cord-005453-4057qib7 3623 8 PRC PRC NNP cord-005453-4057qib7 3623 9 transfusion transfusion NN cord-005453-4057qib7 3623 10 requirement requirement NN cord-005453-4057qib7 3623 11 . . . cord-005453-4057qib7 3624 1 A a DT cord-005453-4057qib7 3624 2 more more RBR cord-005453-4057qib7 3624 3 frequently frequently RB cord-005453-4057qib7 3624 4 occurring occur VBG cord-005453-4057qib7 3624 5 severe severe JJ cord-005453-4057qib7 3624 6 acute acute JJ cord-005453-4057qib7 3624 7 GvHD gvhd NN cord-005453-4057qib7 3624 8 was be VBD cord-005453-4057qib7 3624 9 also also RB cord-005453-4057qib7 3624 10 suggested suggest VBN cord-005453-4057qib7 3624 11 in in IN cord-005453-4057qib7 3624 12 minor minor JJ cord-005453-4057qib7 3624 13 AB0-mismatch ab0-mismatch NN cord-005453-4057qib7 3624 14 transplants transplant NNS cord-005453-4057qib7 3624 15 . . . cord-005453-4057qib7 3625 1 Altogether altogether RB cord-005453-4057qib7 3625 2 , , , cord-005453-4057qib7 3625 3 our -PRON- PRP$ cord-005453-4057qib7 3625 4 results result NNS cord-005453-4057qib7 3625 5 suggest suggest VBP cord-005453-4057qib7 3625 6 that that IN cord-005453-4057qib7 3625 7 allo allo NN cord-005453-4057qib7 3625 8 - - HYPH cord-005453-4057qib7 3625 9 HSCT HSCT NNP cord-005453-4057qib7 3625 10 outcome outcome NN cord-005453-4057qib7 3625 11 may may MD cord-005453-4057qib7 3625 12 be be VB cord-005453-4057qib7 3625 13 significantly significantly RB cord-005453-4057qib7 3625 14 affected affect VBN cord-005453-4057qib7 3625 15 by by IN cord-005453-4057qib7 3625 16 AB0 AB0 NNP cord-005453-4057qib7 3625 17 blood blood NN cord-005453-4057qib7 3625 18 group group NN cord-005453-4057qib7 3625 19 mismatch mismatch NN cord-005453-4057qib7 3625 20 . . . cord-005453-4057qib7 3626 1 Disclosure disclosure NN cord-005453-4057qib7 3626 2 : : : cord-005453-4057qib7 3626 3 Nothing nothing NN cord-005453-4057qib7 3626 4 to to TO cord-005453-4057qib7 3626 5 declare declare VB cord-005453-4057qib7 3626 6 Background background NN cord-005453-4057qib7 3626 7 : : : cord-005453-4057qib7 3627 1 AT AT NNP cord-005453-4057qib7 3627 2 - - HYPH cord-005453-4057qib7 3627 3 TMA TMA NNP cord-005453-4057qib7 3627 4 is be VBZ cord-005453-4057qib7 3627 5 a a DT cord-005453-4057qib7 3627 6 severe severe JJ cord-005453-4057qib7 3627 7 endothelial endothelial JJ cord-005453-4057qib7 3627 8 injury injury NN cord-005453-4057qib7 3627 9 complication complication NN cord-005453-4057qib7 3627 10 and and CC cord-005453-4057qib7 3627 11 it -PRON- PRP cord-005453-4057qib7 3627 12 may may MD cord-005453-4057qib7 3627 13 involve involve VB cord-005453-4057qib7 3627 14 the the DT cord-005453-4057qib7 3627 15 intestinal intestinal JJ cord-005453-4057qib7 3627 16 vasculature vasculature NN cord-005453-4057qib7 3627 17 . . . cord-005453-4057qib7 3628 1 Intestinal intestinal JJ cord-005453-4057qib7 3628 2 TMA TMA NNP cord-005453-4057qib7 3628 3 could could MD cord-005453-4057qib7 3628 4 be be VB cord-005453-4057qib7 3628 5 fatal fatal JJ cord-005453-4057qib7 3628 6 and and CC cord-005453-4057qib7 3628 7 missdiagnosed missdiagnosed JJ cord-005453-4057qib7 3628 8 . . . cord-005453-4057qib7 3629 1 Clinical clinical JJ cord-005453-4057qib7 3629 2 and and CC cord-005453-4057qib7 3629 3 pathological pathological JJ cord-005453-4057qib7 3629 4 criteria criterion NNS cord-005453-4057qib7 3629 5 to to TO cord-005453-4057qib7 3629 6 differentiate differentiate VB cord-005453-4057qib7 3629 7 from from IN cord-005453-4057qib7 3629 8 intestinal intestinal JJ cord-005453-4057qib7 3629 9 GVHD GVHD NNP cord-005453-4057qib7 3629 10 are be VBP cord-005453-4057qib7 3629 11 needed need VBN cord-005453-4057qib7 3629 12 . . . cord-005453-4057qib7 3630 1 The the DT cord-005453-4057qib7 3630 2 aim aim NN cord-005453-4057qib7 3630 3 of of IN cord-005453-4057qib7 3630 4 this this DT cord-005453-4057qib7 3630 5 study study NN cord-005453-4057qib7 3630 6 was be VBD cord-005453-4057qib7 3630 7 to to TO cord-005453-4057qib7 3630 8 analyze analyze VB cord-005453-4057qib7 3630 9 the the DT cord-005453-4057qib7 3630 10 incidence incidence NN cord-005453-4057qib7 3630 11 and and CC cord-005453-4057qib7 3630 12 histological histological JJ cord-005453-4057qib7 3630 13 characteristics characteristic NNS cord-005453-4057qib7 3630 14 of of IN cord-005453-4057qib7 3630 15 intestinal intestinal JJ cord-005453-4057qib7 3630 16 TMA TMA NNP cord-005453-4057qib7 3630 17 in in IN cord-005453-4057qib7 3630 18 patients patient NNS cord-005453-4057qib7 3630 19 diagnosed diagnose VBN cord-005453-4057qib7 3630 20 of of IN cord-005453-4057qib7 3630 21 systemic systemic JJ cord-005453-4057qib7 3630 22 TMA TMA NNP cord-005453-4057qib7 3630 23 . . . cord-005453-4057qib7 3631 1 Methods method NNS cord-005453-4057qib7 3631 2 : : : cord-005453-4057qib7 3631 3 We -PRON- PRP cord-005453-4057qib7 3631 4 analyzed analyze VBD cord-005453-4057qib7 3631 5 the the DT cord-005453-4057qib7 3631 6 incidence incidence NN cord-005453-4057qib7 3631 7 of of IN cord-005453-4057qib7 3631 8 TMA TMA NNP cord-005453-4057qib7 3631 9 in in IN cord-005453-4057qib7 3631 10 555 555 CD cord-005453-4057qib7 3631 11 patients patient NNS cord-005453-4057qib7 3631 12 who who WP cord-005453-4057qib7 3631 13 underwent undergo VBD cord-005453-4057qib7 3631 14 allo allo NN cord-005453-4057qib7 3631 15 - - HYPH cord-005453-4057qib7 3631 16 HSCT HSCT NNP cord-005453-4057qib7 3631 17 in in IN cord-005453-4057qib7 3631 18 our -PRON- PRP$ cord-005453-4057qib7 3631 19 institution institution NN cord-005453-4057qib7 3631 20 between between IN cord-005453-4057qib7 3631 21 january january NNP cord-005453-4057qib7 3631 22 2010-august 2010-august CD cord-005453-4057qib7 3631 23 2018 2018 CD cord-005453-4057qib7 3631 24 . . . cord-005453-4057qib7 3632 1 TMA TMA NNP cord-005453-4057qib7 3632 2 diagnosis diagnosis NN cord-005453-4057qib7 3632 3 was be VBD cord-005453-4057qib7 3632 4 based base VBN cord-005453-4057qib7 3632 5 on on IN cord-005453-4057qib7 3632 6 Ho Ho NNP cord-005453-4057qib7 3632 7 criteria criterion NNS cord-005453-4057qib7 3632 8 . . . cord-005453-4057qib7 3633 1 We -PRON- PRP cord-005453-4057qib7 3633 2 do do VBP cord-005453-4057qib7 3633 3 a a DT cord-005453-4057qib7 3633 4 pathological pathological JJ cord-005453-4057qib7 3633 5 review review NN cord-005453-4057qib7 3633 6 in in IN cord-005453-4057qib7 3633 7 103 103 CD cord-005453-4057qib7 3633 8 biopsies biopsy NNS cord-005453-4057qib7 3633 9 from from IN cord-005453-4057qib7 3633 10 25 25 CD cord-005453-4057qib7 3633 11 out out IN cord-005453-4057qib7 3633 12 of of IN cord-005453-4057qib7 3633 13 52 52 CD cord-005453-4057qib7 3633 14 patients patient NNS cord-005453-4057qib7 3633 15 in in IN cord-005453-4057qib7 3633 16 whom whom WP cord-005453-4057qib7 3633 17 an an DT cord-005453-4057qib7 3633 18 endoscopy endoscopy NN cord-005453-4057qib7 3633 19 have have VBP cord-005453-4057qib7 3633 20 been be VBN cord-005453-4057qib7 3633 21 performed perform VBN cord-005453-4057qib7 3633 22 30 30 CD cord-005453-4057qib7 3633 23 days day NNS cord-005453-4057qib7 3633 24 before before RB cord-005453-4057qib7 3633 25 and and CC cord-005453-4057qib7 3633 26 60 60 CD cord-005453-4057qib7 3633 27 days day NNS cord-005453-4057qib7 3633 28 after after IN cord-005453-4057qib7 3633 29 the the DT cord-005453-4057qib7 3633 30 diagnosis diagnosis NN cord-005453-4057qib7 3633 31 of of IN cord-005453-4057qib7 3633 32 TMA TMA NNP cord-005453-4057qib7 3633 33 for for IN cord-005453-4057qib7 3633 34 suspicious suspicious JJ cord-005453-4057qib7 3633 35 of of IN cord-005453-4057qib7 3633 36 GVHD GVHD NNP cord-005453-4057qib7 3633 37 . . . cord-005453-4057qib7 3634 1 Review Review NNP cord-005453-4057qib7 3634 2 was be VBD cord-005453-4057qib7 3634 3 performed perform VBN cord-005453-4057qib7 3634 4 by by IN cord-005453-4057qib7 3634 5 a a DT cord-005453-4057qib7 3634 6 pathologist pathologist NN cord-005453-4057qib7 3634 7 expert expert NN cord-005453-4057qib7 3634 8 in in IN cord-005453-4057qib7 3634 9 GVHD GVHD NNP cord-005453-4057qib7 3634 10 , , , cord-005453-4057qib7 3634 11 who who WP cord-005453-4057qib7 3634 12 examined examine VBD cord-005453-4057qib7 3634 13 the the DT cord-005453-4057qib7 3634 14 biopsies biopsy NNS cord-005453-4057qib7 3634 15 in in IN cord-005453-4057qib7 3634 16 search search NN cord-005453-4057qib7 3634 17 of of IN cord-005453-4057qib7 3634 18 hystopathological hystopathological JJ cord-005453-4057qib7 3634 19 features feature NNS cord-005453-4057qib7 3634 20 of of IN cord-005453-4057qib7 3634 21 GVHD GVHD NNP cord-005453-4057qib7 3634 22 , , , cord-005453-4057qib7 3634 23 TMA TMA NNP cord-005453-4057qib7 3634 24 or or CC cord-005453-4057qib7 3634 25 viral viral JJ cord-005453-4057qib7 3634 26 infection infection NN cord-005453-4057qib7 3634 27 . . . cord-005453-4057qib7 3635 1 Diagnosis diagnosis NN cord-005453-4057qib7 3635 2 of of IN cord-005453-4057qib7 3635 3 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 3635 4 GVHD GVHD NNP cord-005453-4057qib7 3635 5 was be VBD cord-005453-4057qib7 3635 6 stablished stablishe VBN cord-005453-4057qib7 3635 7 according accord VBG cord-005453-4057qib7 3635 8 to to IN cord-005453-4057qib7 3635 9 Mcdonald Mcdonald NNP cord-005453-4057qib7 3635 10 and and CC cord-005453-4057qib7 3635 11 Sales Sales NNP cord-005453-4057qib7 3635 12 criteria criterion NNS cord-005453-4057qib7 3635 13 , , , cord-005453-4057qib7 3635 14 while while IN cord-005453-4057qib7 3635 15 intestinal intestinal JJ cord-005453-4057qib7 3635 16 TMA TMA NNP cord-005453-4057qib7 3635 17 diagnosis diagnosis NN cord-005453-4057qib7 3635 18 was be VBD cord-005453-4057qib7 3635 19 stablished stablishe VBN cord-005453-4057qib7 3635 20 by by IN cord-005453-4057qib7 3635 21 Warren Warren NNP cord-005453-4057qib7 3635 22 et et NNP cord-005453-4057qib7 3635 23 al al NNP cord-005453-4057qib7 3635 24 criteria criterion NNS cord-005453-4057qib7 3635 25 . . . cord-005453-4057qib7 3636 1 Results result NNS cord-005453-4057qib7 3636 2 : : : cord-005453-4057qib7 3636 3 52 52 CD cord-005453-4057qib7 3636 4 out out IN cord-005453-4057qib7 3636 5 of of IN cord-005453-4057qib7 3636 6 555 555 CD cord-005453-4057qib7 3636 7 patients patient NNS cord-005453-4057qib7 3636 8 ( ( -LRB- cord-005453-4057qib7 3636 9 9,4 9,4 CD cord-005453-4057qib7 3636 10 % % NN cord-005453-4057qib7 3636 11 ) ) -RRB- cord-005453-4057qib7 3636 12 were be VBD cord-005453-4057qib7 3636 13 diagnosed diagnose VBN cord-005453-4057qib7 3636 14 of of IN cord-005453-4057qib7 3636 15 TMA TMA NNP cord-005453-4057qib7 3636 16 . . . cord-005453-4057qib7 3637 1 Transplant transplant NN cord-005453-4057qib7 3637 2 characteristics characteristic NNS cord-005453-4057qib7 3637 3 and and CC cord-005453-4057qib7 3637 4 TMA TMA NNP cord-005453-4057qib7 3637 5 data datum NNS cord-005453-4057qib7 3637 6 of of IN cord-005453-4057qib7 3637 7 patients patient NNS cord-005453-4057qib7 3637 8 with with IN cord-005453-4057qib7 3637 9 systemic systemic JJ cord-005453-4057qib7 3637 10 TMA TMA NNP cord-005453-4057qib7 3637 11 are be VBP cord-005453-4057qib7 3637 12 shown show VBN cord-005453-4057qib7 3637 13 in in IN cord-005453-4057qib7 3637 14 image image NN cord-005453-4057qib7 3637 15 . . . cord-005453-4057qib7 3638 1 47 47 CD cord-005453-4057qib7 3638 2 out out IN cord-005453-4057qib7 3638 3 of of IN cord-005453-4057qib7 3638 4 52 52 CD cord-005453-4057qib7 3638 5 patients patient NNS cord-005453-4057qib7 3638 6 with with IN cord-005453-4057qib7 3638 7 TMA TMA NNP cord-005453-4057qib7 3638 8 ( ( -LRB- cord-005453-4057qib7 3638 9 90 90 CD cord-005453-4057qib7 3638 10 % % NN cord-005453-4057qib7 3638 11 ) ) -RRB- cord-005453-4057qib7 3638 12 had have VBD cord-005453-4057qib7 3638 13 been be VBN cord-005453-4057qib7 3638 14 diagnosed diagnose VBN cord-005453-4057qib7 3638 15 with with IN cord-005453-4057qib7 3638 16 prior/ prior/ CD cord-005453-4057qib7 3638 17 simultaneous simultaneous JJ cord-005453-4057qib7 3638 18 acute acute JJ cord-005453-4057qib7 3638 19 GVHD GVHD NNP cord-005453-4057qib7 3638 20 , , , cord-005453-4057qib7 3638 21 20 20 CD cord-005453-4057qib7 3638 22 of of IN cord-005453-4057qib7 3638 23 them -PRON- PRP cord-005453-4057qib7 3638 24 grade grade NN cord-005453-4057qib7 3638 25 III III NNP cord-005453-4057qib7 3638 26 - - HYPH cord-005453-4057qib7 3638 27 IV IV NNP cord-005453-4057qib7 3638 28 , , , cord-005453-4057qib7 3638 29 and and CC cord-005453-4057qib7 3638 30 80 80 CD cord-005453-4057qib7 3638 31 % % NN cord-005453-4057qib7 3638 32 with with IN cord-005453-4057qib7 3638 33 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 3638 34 GVHD GVHD NNP cord-005453-4057qib7 3638 35 . . . cord-005453-4057qib7 3639 1 Intestinal intestinal JJ cord-005453-4057qib7 3639 2 TMA TMA NNP cord-005453-4057qib7 3639 3 have have VBP cord-005453-4057qib7 3639 4 been be VBN cord-005453-4057qib7 3639 5 reported report VBN cord-005453-4057qib7 3639 6 only only RB cord-005453-4057qib7 3639 7 in in IN cord-005453-4057qib7 3639 8 7 7 CD cord-005453-4057qib7 3639 9 out out IN cord-005453-4057qib7 3639 10 of of IN cord-005453-4057qib7 3639 11 25 25 CD cord-005453-4057qib7 3639 12 patients patient NNS cord-005453-4057qib7 3639 13 ( ( -LRB- cord-005453-4057qib7 3639 14 28 28 CD cord-005453-4057qib7 3639 15 % % NN cord-005453-4057qib7 3639 16 ) ) -RRB- cord-005453-4057qib7 3639 17 at at IN cord-005453-4057qib7 3639 18 diagnosis diagnosis NN cord-005453-4057qib7 3639 19 , , , cord-005453-4057qib7 3639 20 whereas whereas IN cord-005453-4057qib7 3639 21 when when WRB cord-005453-4057qib7 3639 22 review review NN cord-005453-4057qib7 3639 23 based base VBN cord-005453-4057qib7 3639 24 on on IN cord-005453-4057qib7 3639 25 Warren Warren NNP cord-005453-4057qib7 3639 26 criteria criterion NNS cord-005453-4057qib7 3639 27 was be VBD cord-005453-4057qib7 3639 28 performed perform VBN cord-005453-4057qib7 3639 29 , , , cord-005453-4057qib7 3639 30 in in IN cord-005453-4057qib7 3639 31 19 19 CD cord-005453-4057qib7 3639 32 patients patient NNS cord-005453-4057qib7 3639 33 ( ( -LRB- cord-005453-4057qib7 3639 34 76 76 CD cord-005453-4057qib7 3639 35 % % NN cord-005453-4057qib7 3639 36 ) ) -RRB- cord-005453-4057qib7 3640 1 the the DT cord-005453-4057qib7 3640 2 pathologist pathologist NN cord-005453-4057qib7 3640 3 found find VBD cord-005453-4057qib7 3640 4 at at IN cord-005453-4057qib7 3640 5 least least JJS cord-005453-4057qib7 3640 6 1 1 CD cord-005453-4057qib7 3640 7 of of IN cord-005453-4057qib7 3640 8 the the DT cord-005453-4057qib7 3640 9 criteria criterion NNS cord-005453-4057qib7 3640 10 of of IN cord-005453-4057qib7 3640 11 endothelial endothelial JJ cord-005453-4057qib7 3640 12 damage damage NN cord-005453-4057qib7 3640 13 and and CC cord-005453-4057qib7 3640 14 48 48 CD cord-005453-4057qib7 3640 15 % % NN cord-005453-4057qib7 3640 16 of of IN cord-005453-4057qib7 3640 17 the the DT cord-005453-4057qib7 3640 18 patients patient NNS cord-005453-4057qib7 3640 19 3 3 CD cord-005453-4057qib7 3640 20 or or CC cord-005453-4057qib7 3640 21 more more JJR cord-005453-4057qib7 3640 22 Warren Warren NNP cord-005453-4057qib7 3640 23 criteria criterion NNS cord-005453-4057qib7 3640 24 were be VBD cord-005453-4057qib7 3640 25 founded found VBN cord-005453-4057qib7 3640 26 . . . cord-005453-4057qib7 3641 1 The the DT cord-005453-4057qib7 3641 2 most most RBS cord-005453-4057qib7 3641 3 frequent frequent JJ cord-005453-4057qib7 3641 4 features feature NNS cord-005453-4057qib7 3641 5 were be VBD cord-005453-4057qib7 3641 6 endothelial endothelial JJ cord-005453-4057qib7 3641 7 cell cell NN cord-005453-4057qib7 3641 8 swelling swelling NN cord-005453-4057qib7 3641 9 ( ( -LRB- cord-005453-4057qib7 3641 10 n=16 n=16 NNP cord-005453-4057qib7 3641 11 , , , cord-005453-4057qib7 3641 12 64 64 CD cord-005453-4057qib7 3641 13 % % NN cord-005453-4057qib7 3641 14 ) ) -RRB- cord-005453-4057qib7 3641 15 and and CC cord-005453-4057qib7 3641 16 perivascular perivascular JJ cord-005453-4057qib7 3641 17 mucosal mucosal JJ cord-005453-4057qib7 3641 18 hemorrhage hemorrhage NN cord-005453-4057qib7 3641 19 ( ( -LRB- cord-005453-4057qib7 3641 20 n=15 n=15 NNP cord-005453-4057qib7 3641 21 , , , cord-005453-4057qib7 3641 22 60 60 CD cord-005453-4057qib7 3641 23 % % NN cord-005453-4057qib7 3641 24 ) ) -RRB- cord-005453-4057qib7 3641 25 . . . cord-005453-4057qib7 3642 1 Review review VB cord-005453-4057qib7 3642 2 hystological hystological NN cord-005453-4057qib7 3642 3 features feature NNS cord-005453-4057qib7 3642 4 of of IN cord-005453-4057qib7 3642 5 biopsies biopsy NNS cord-005453-4057qib7 3642 6 are be VBP cord-005453-4057qib7 3642 7 shown show VBN cord-005453-4057qib7 3642 8 in in IN cord-005453-4057qib7 3642 9 table table NN cord-005453-4057qib7 3642 10 3 3 CD cord-005453-4057qib7 3642 11 of of IN cord-005453-4057qib7 3642 12 the the DT cord-005453-4057qib7 3642 13 image image NN cord-005453-4057qib7 3642 14 . . . cord-005453-4057qib7 3643 1 Regarding regard VBG cord-005453-4057qib7 3643 2 GVHD GVHD NNP cord-005453-4057qib7 3643 3 , , , cord-005453-4057qib7 3643 4 it -PRON- PRP cord-005453-4057qib7 3643 5 was be VBD cord-005453-4057qib7 3643 6 found find VBN cord-005453-4057qib7 3643 7 in in IN cord-005453-4057qib7 3643 8 21 21 CD cord-005453-4057qib7 3643 9 patients patient NNS cord-005453-4057qib7 3643 10 ( ( -LRB- cord-005453-4057qib7 3643 11 84 84 CD cord-005453-4057qib7 3643 12 % % NN cord-005453-4057qib7 3643 13 ) ) -RRB- cord-005453-4057qib7 3643 14 at at IN cord-005453-4057qib7 3643 15 diagnosis diagnosis NN cord-005453-4057qib7 3643 16 and and CC cord-005453-4057qib7 3643 17 in in IN cord-005453-4057qib7 3643 18 23 23 CD cord-005453-4057qib7 3643 19 ( ( -LRB- cord-005453-4057qib7 3643 20 92 92 CD cord-005453-4057qib7 3643 21 % % NN cord-005453-4057qib7 3643 22 ) ) -RRB- cord-005453-4057qib7 3643 23 at at IN cord-005453-4057qib7 3643 24 pathological pathological JJ cord-005453-4057qib7 3643 25 review review NN cord-005453-4057qib7 3643 26 . . . cord-005453-4057qib7 3644 1 With with IN cord-005453-4057qib7 3644 2 a a DT cord-005453-4057qib7 3644 3 median median JJ cord-005453-4057qib7 3644 4 follow follow NN cord-005453-4057qib7 3644 5 - - HYPH cord-005453-4057qib7 3644 6 up up NN cord-005453-4057qib7 3644 7 of of IN cord-005453-4057qib7 3644 8 10 10 CD cord-005453-4057qib7 3644 9 months month NNS cord-005453-4057qib7 3644 10 ( ( -LRB- cord-005453-4057qib7 3644 11 1 1 CD cord-005453-4057qib7 3644 12 - - SYM cord-005453-4057qib7 3644 13 73 73 CD cord-005453-4057qib7 3644 14 ) ) -RRB- cord-005453-4057qib7 3644 15 32 32 CD cord-005453-4057qib7 3644 16 patients patient NNS cord-005453-4057qib7 3644 17 of of IN cord-005453-4057qib7 3644 18 the the DT cord-005453-4057qib7 3644 19 52 52 CD cord-005453-4057qib7 3644 20 with with IN cord-005453-4057qib7 3644 21 systemic systemic JJ cord-005453-4057qib7 3644 22 TMA TMA NNP cord-005453-4057qib7 3644 23 ( ( -LRB- cord-005453-4057qib7 3644 24 62 62 CD cord-005453-4057qib7 3644 25 % % NN cord-005453-4057qib7 3644 26 ) ) -RRB- cord-005453-4057qib7 3644 27 are be VBP cord-005453-4057qib7 3644 28 dead dead JJ cord-005453-4057qib7 3644 29 . . . cord-005453-4057qib7 3645 1 9 9 CD cord-005453-4057qib7 3645 2 of of IN cord-005453-4057qib7 3645 3 the the DT cord-005453-4057qib7 3645 4 deaths death NNS cord-005453-4057qib7 3645 5 ( ( -LRB- cord-005453-4057qib7 3645 6 41 41 CD cord-005453-4057qib7 3645 7 % % NN cord-005453-4057qib7 3645 8 ) ) -RRB- cord-005453-4057qib7 3645 9 were be VBD cord-005453-4057qib7 3645 10 related relate VBN cord-005453-4057qib7 3645 11 to to IN cord-005453-4057qib7 3645 12 TMA TMA NNP cord-005453-4057qib7 3645 13 ( ( -LRB- cord-005453-4057qib7 3645 14 3 3 CD cord-005453-4057qib7 3645 15 TMA TMA NNP cord-005453-4057qib7 3645 16 , , , cord-005453-4057qib7 3645 17 3 3 CD cord-005453-4057qib7 3645 18 TMA TMA NNP cord-005453-4057qib7 3645 19 + + CC cord-005453-4057qib7 3645 20 GVHD GVHD NNP cord-005453-4057qib7 3645 21 , , , cord-005453-4057qib7 3645 22 and and CC cord-005453-4057qib7 3645 23 3 3 CD cord-005453-4057qib7 3645 24 TMA+infection tma+infection NN cord-005453-4057qib7 3645 25 ) ) -RRB- cord-005453-4057qib7 3645 26 . . . cord-005453-4057qib7 3646 1 Patients patient NNS cord-005453-4057qib7 3646 2 with with IN cord-005453-4057qib7 3646 3 3 3 CD cord-005453-4057qib7 3646 4 or or CC cord-005453-4057qib7 3646 5 more more JJR cord-005453-4057qib7 3646 6 Warren Warren NNP cord-005453-4057qib7 3646 7 criteria criterion NNS cord-005453-4057qib7 3646 8 in in IN cord-005453-4057qib7 3646 9 pathological pathological JJ cord-005453-4057qib7 3646 10 review review NN cord-005453-4057qib7 3646 11 had have VBD cord-005453-4057qib7 3646 12 poor poor JJ cord-005453-4057qib7 3646 13 outcome outcome NN cord-005453-4057qib7 3646 14 compared compare VBN cord-005453-4057qib7 3646 15 with with IN cord-005453-4057qib7 3646 16 patients patient NNS cord-005453-4057qib7 3646 17 less less JJR cord-005453-4057qib7 3646 18 than than IN cord-005453-4057qib7 3646 19 3 3 CD cord-005453-4057qib7 3646 20 criteria criterion NNS cord-005453-4057qib7 3646 21 ( ( -LRB- cord-005453-4057qib7 3646 22 30 30 CD cord-005453-4057qib7 3646 23 % % NN cord-005453-4057qib7 3646 24 alive alive JJ cord-005453-4057qib7 3646 25 VS VS NNP cord-005453-4057qib7 3646 26 51 51 CD cord-005453-4057qib7 3646 27 % % NN cord-005453-4057qib7 3646 28 at at IN cord-005453-4057qib7 3646 29 12 12 CD cord-005453-4057qib7 3646 30 months month NNS cord-005453-4057qib7 3646 31 , , , cord-005453-4057qib7 3646 32 p=0.9 p=0.9 NNP cord-005453-4057qib7 3646 33 ) ) -RRB- cord-005453-4057qib7 3646 34 . . . cord-005453-4057qib7 3647 1 Conclusions conclusion NNS cord-005453-4057qib7 3647 2 : : : cord-005453-4057qib7 3648 1 Intestinal intestinal JJ cord-005453-4057qib7 3648 2 TMA TMA NNP cord-005453-4057qib7 3648 3 is be VBZ cord-005453-4057qib7 3648 4 a a DT cord-005453-4057qib7 3648 5 life life NN cord-005453-4057qib7 3648 6 - - HYPH cord-005453-4057qib7 3648 7 threatening threaten VBG cord-005453-4057qib7 3648 8 underdiagnosed underdiagnosed JJ cord-005453-4057qib7 3648 9 entity entity NN cord-005453-4057qib7 3648 10 . . . cord-005453-4057qib7 3649 1 Only only RB cord-005453-4057qib7 3649 2 7 7 CD cord-005453-4057qib7 3649 3 patients patient NNS cord-005453-4057qib7 3649 4 of of IN cord-005453-4057qib7 3649 5 25 25 CD cord-005453-4057qib7 3649 6 patients patient NNS cord-005453-4057qib7 3649 7 were be VBD cord-005453-4057qib7 3649 8 diagnosed diagnose VBN cord-005453-4057qib7 3649 9 of of IN cord-005453-4057qib7 3649 10 intestinal intestinal JJ cord-005453-4057qib7 3649 11 TMA TMA NNP cord-005453-4057qib7 3649 12 . . . cord-005453-4057qib7 3650 1 We -PRON- PRP cord-005453-4057qib7 3650 2 found find VBD cord-005453-4057qib7 3650 3 that that IN cord-005453-4057qib7 3650 4 most most JJS cord-005453-4057qib7 3650 5 of of IN cord-005453-4057qib7 3650 6 our -PRON- PRP$ cord-005453-4057qib7 3650 7 patients patient NNS cord-005453-4057qib7 3650 8 had have VBD cord-005453-4057qib7 3650 9 endothelial endothelial JJ cord-005453-4057qib7 3650 10 damage damage NN cord-005453-4057qib7 3650 11 in in IN cord-005453-4057qib7 3650 12 the the DT cord-005453-4057qib7 3650 13 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 3650 14 biopsy biopsy JJ cord-005453-4057qib7 3650 15 pathological pathological JJ cord-005453-4057qib7 3650 16 reviews review NNS cord-005453-4057qib7 3650 17 . . . cord-005453-4057qib7 3651 1 GVHD gvhd JJ cord-005453-4057qib7 3651 2 histological histological JJ cord-005453-4057qib7 3651 3 criteria criterion NNS cord-005453-4057qib7 3651 4 were be VBD cord-005453-4057qib7 3651 5 present present JJ cord-005453-4057qib7 3651 6 in in IN cord-005453-4057qib7 3651 7 most most JJS cord-005453-4057qib7 3651 8 of of IN cord-005453-4057qib7 3651 9 the the DT cord-005453-4057qib7 3651 10 patients patient NNS cord-005453-4057qib7 3651 11 , , , cord-005453-4057qib7 3651 12 mainly mainly RB cord-005453-4057qib7 3651 13 histological histological JJ cord-005453-4057qib7 3651 14 grade grade NN cord-005453-4057qib7 3651 15 I I NNP cord-005453-4057qib7 3651 16 - - HYPH cord-005453-4057qib7 3651 17 II II NNP cord-005453-4057qib7 3651 18 . . . cord-005453-4057qib7 3652 1 Prognosis prognosis NN cord-005453-4057qib7 3652 2 of of IN cord-005453-4057qib7 3652 3 these these DT cord-005453-4057qib7 3652 4 patients patient NNS cord-005453-4057qib7 3652 5 is be VBZ cord-005453-4057qib7 3652 6 poor poor JJ cord-005453-4057qib7 3652 7 and and CC cord-005453-4057qib7 3652 8 pathologist pathologist NN cord-005453-4057qib7 3652 9 effords efford NNS cord-005453-4057qib7 3652 10 in in IN cord-005453-4057qib7 3652 11 diagnosed diagnose VBN cord-005453-4057qib7 3653 1 the the DT cord-005453-4057qib7 3653 2 entity entity NN cord-005453-4057qib7 3653 3 is be VBZ cord-005453-4057qib7 3653 4 guarranted guarrante VBN cord-005453-4057qib7 3653 5 . . . cord-005453-4057qib7 3654 1 Disclosure disclosure NN cord-005453-4057qib7 3654 2 : : : cord-005453-4057qib7 3654 3 Nothing nothing NN cord-005453-4057qib7 3654 4 to to IN cord-005453-4057qib7 3654 5 disclosure disclosure NN cord-005453-4057qib7 3654 6 P175 P175 `` cord-005453-4057qib7 3654 7 Strategies strategy NNS cord-005453-4057qib7 3654 8 to to TO cord-005453-4057qib7 3654 9 reduce reduce VB cord-005453-4057qib7 3654 10 neutropenic neutropenic JJ cord-005453-4057qib7 3654 11 fever fever NN cord-005453-4057qib7 3654 12 and and CC cord-005453-4057qib7 3654 13 hospital hospital NN cord-005453-4057qib7 3654 14 readmission readmission NN cord-005453-4057qib7 3654 15 in in IN cord-005453-4057qib7 3654 16 multiple multiple JJ cord-005453-4057qib7 3654 17 myeloma myeloma NN cord-005453-4057qib7 3654 18 patients patient NNS cord-005453-4057qib7 3654 19 managed manage VBD cord-005453-4057qib7 3654 20 at at IN cord-005453-4057qib7 3654 21 home home NN cord-005453-4057qib7 3654 22 after after IN cord-005453-4057qib7 3654 23 autologous autologous JJ cord-005453-4057qib7 3654 24 stem stem NN cord-005453-4057qib7 3654 25 cell cell NN cord-005453-4057qib7 3654 26 transplantation transplantation NN cord-005453-4057qib7 3654 27 Background background NN cord-005453-4057qib7 3654 28 : : : cord-005453-4057qib7 3655 1 Neutropenic neutropenic JJ cord-005453-4057qib7 3655 2 fever fever NN cord-005453-4057qib7 3655 3 ( ( -LRB- cord-005453-4057qib7 3655 4 NF NF NNP cord-005453-4057qib7 3655 5 ) ) -RRB- cord-005453-4057qib7 3655 6 is be VBZ cord-005453-4057qib7 3655 7 the the DT cord-005453-4057qib7 3655 8 most most RBS cord-005453-4057qib7 3655 9 frequent frequent JJ cord-005453-4057qib7 3655 10 cause cause NN cord-005453-4057qib7 3655 11 of of IN cord-005453-4057qib7 3655 12 readmission readmission NN cord-005453-4057qib7 3655 13 in in IN cord-005453-4057qib7 3655 14 the the DT cord-005453-4057qib7 3655 15 outpatient outpatient NN cord-005453-4057qib7 3655 16 autologous autologous JJ cord-005453-4057qib7 3655 17 stem stem NN cord-005453-4057qib7 3655 18 cell cell NN cord-005453-4057qib7 3655 19 transplantation transplantation NN cord-005453-4057qib7 3655 20 ( ( -LRB- cord-005453-4057qib7 3655 21 ASCT ASCT NNP cord-005453-4057qib7 3655 22 ) ) -RRB- cord-005453-4057qib7 3655 23 programs program NNS cord-005453-4057qib7 3655 24 . . . cord-005453-4057qib7 3656 1 In in IN cord-005453-4057qib7 3656 2 our -PRON- PRP$ cord-005453-4057qib7 3656 3 at at IN cord-005453-4057qib7 3656 4 home home NN cord-005453-4057qib7 3656 5 model model NN cord-005453-4057qib7 3656 6 for for IN cord-005453-4057qib7 3656 7 multiple multiple JJ cord-005453-4057qib7 3656 8 myeloma myeloma NN cord-005453-4057qib7 3656 9 patients patient NNS cord-005453-4057qib7 3656 10 , , , cord-005453-4057qib7 3656 11 we -PRON- PRP cord-005453-4057qib7 3656 12 added add VBD cord-005453-4057qib7 3656 13 primary primary JJ cord-005453-4057qib7 3656 14 prophylaxis prophylaxis NN cord-005453-4057qib7 3656 15 with with IN cord-005453-4057qib7 3656 16 ceftriaxone ceftriaxone NN cord-005453-4057qib7 3656 17 , , , cord-005453-4057qib7 3656 18 decreasing decrease VBG cord-005453-4057qib7 3656 19 the the DT cord-005453-4057qib7 3656 20 incidence incidence NN cord-005453-4057qib7 3656 21 of of IN cord-005453-4057qib7 3656 22 fever fever NN cord-005453-4057qib7 3656 23 during during IN cord-005453-4057qib7 3656 24 aplasia aplasia JJ cord-005453-4057qib7 3656 25 phase phase NN cord-005453-4057qib7 3656 26 from from IN cord-005453-4057qib7 3656 27 85 85 CD cord-005453-4057qib7 3656 28 % % NN cord-005453-4057qib7 3656 29 to to IN cord-005453-4057qib7 3656 30 57.6 57.6 CD cord-005453-4057qib7 3656 31 % % NN cord-005453-4057qib7 3656 32 . . . cord-005453-4057qib7 3657 1 The the DT cord-005453-4057qib7 3657 2 aim aim NN cord-005453-4057qib7 3657 3 of of IN cord-005453-4057qib7 3657 4 this this DT cord-005453-4057qib7 3657 5 study study NN cord-005453-4057qib7 3657 6 was be VBD cord-005453-4057qib7 3657 7 to to TO cord-005453-4057qib7 3657 8 analyze analyze VB cord-005453-4057qib7 3657 9 the the DT cord-005453-4057qib7 3657 10 addition addition NN cord-005453-4057qib7 3657 11 of of IN cord-005453-4057qib7 3657 12 two two CD cord-005453-4057qib7 3657 13 strategies strategy NNS cord-005453-4057qib7 3657 14 to to TO cord-005453-4057qib7 3657 15 reduce reduce VB cord-005453-4057qib7 3657 16 the the DT cord-005453-4057qib7 3657 17 non non JJ cord-005453-4057qib7 3657 18 - - JJ cord-005453-4057qib7 3657 19 infectious infectious JJ cord-005453-4057qib7 3657 20 NF nf NN cord-005453-4057qib7 3657 21 : : : cord-005453-4057qib7 3657 22 withdrawal withdrawal NN cord-005453-4057qib7 3657 23 of of IN cord-005453-4057qib7 3657 24 G G NNP cord-005453-4057qib7 3657 25 - - HYPH cord-005453-4057qib7 3657 26 CSF CSF NNP cord-005453-4057qib7 3657 27 and and CC cord-005453-4057qib7 3657 28 the the DT cord-005453-4057qib7 3657 29 addition addition NN cord-005453-4057qib7 3657 30 of of IN cord-005453-4057qib7 3657 31 primary primary JJ cord-005453-4057qib7 3657 32 prophylaxis prophylaxis NN cord-005453-4057qib7 3657 33 for for IN cord-005453-4057qib7 3657 34 engraftment engraftment NNP cord-005453-4057qib7 3657 35 syndrome syndrome NN cord-005453-4057qib7 3657 36 with with IN cord-005453-4057qib7 3657 37 corticosteroids corticosteroid NNS cord-005453-4057qib7 3657 38 after after IN cord-005453-4057qib7 3657 39 ASCT ASCT NNP cord-005453-4057qib7 3657 40 . . . cord-005453-4057qib7 3658 1 Methods method NNS cord-005453-4057qib7 3658 2 : : : cord-005453-4057qib7 3658 3 Between between IN cord-005453-4057qib7 3658 4 January January NNP cord-005453-4057qib7 3658 5 2002 2002 CD cord-005453-4057qib7 3658 6 and and CC cord-005453-4057qib7 3658 7 August August NNP cord-005453-4057qib7 3658 8 2018 2018 CD cord-005453-4057qib7 3658 9 111 111 CD cord-005453-4057qib7 3658 10 myeloma myeloma NN cord-005453-4057qib7 3658 11 patients patient NNS cord-005453-4057qib7 3658 12 were be VBD cord-005453-4057qib7 3658 13 managed manage VBN cord-005453-4057qib7 3658 14 at at IN cord-005453-4057qib7 3658 15 - - HYPH cord-005453-4057qib7 3658 16 home home NN cord-005453-4057qib7 3658 17 since since IN cord-005453-4057qib7 3658 18 day day NN cord-005453-4057qib7 3658 19 +1 +1 NNS cord-005453-4057qib7 3658 20 of of IN cord-005453-4057qib7 3658 21 ASCT ASCT NNP cord-005453-4057qib7 3658 22 . . . cord-005453-4057qib7 3659 1 All all DT cord-005453-4057qib7 3659 2 were be VBD cord-005453-4057qib7 3659 3 conditioned condition VBN cord-005453-4057qib7 3659 4 with with IN cord-005453-4057qib7 3659 5 Mel200 mel200 NN cord-005453-4057qib7 3659 6 . . . cord-005453-4057qib7 3660 1 All all DT cord-005453-4057qib7 3660 2 patients patient NNS cord-005453-4057qib7 3660 3 received receive VBD cord-005453-4057qib7 3660 4 prophylaxis prophylaxis NN cord-005453-4057qib7 3660 5 with with IN cord-005453-4057qib7 3660 6 quinolone quinolone NNP cord-005453-4057qib7 3660 7 , , , cord-005453-4057qib7 3660 8 fluconazole fluconazole NNP cord-005453-4057qib7 3660 9 , , , cord-005453-4057qib7 3660 10 aerolized aerolize VBN cord-005453-4057qib7 3660 11 pentamidine pentamidine NNP cord-005453-4057qib7 3660 12 , , , cord-005453-4057qib7 3660 13 low low JJ cord-005453-4057qib7 3660 14 - - HYPH cord-005453-4057qib7 3660 15 dose dose NN cord-005453-4057qib7 3660 16 acyclovir acyclovir NN cord-005453-4057qib7 3660 17 ( ( -LRB- cord-005453-4057qib7 3660 18 HVS+ HVS+ NNP cord-005453-4057qib7 3660 19 ) ) -RRB- cord-005453-4057qib7 3660 20 , , , cord-005453-4057qib7 3660 21 and and CC cord-005453-4057qib7 3660 22 ceftriaxone ceftriaxone NN cord-005453-4057qib7 3660 23 ( ( -LRB- cord-005453-4057qib7 3660 24 since since IN cord-005453-4057qib7 3660 25 day day NN cord-005453-4057qib7 3660 26 +4 +4 NN cord-005453-4057qib7 3660 27 ) ) -RRB- cord-005453-4057qib7 3660 28 . . . cord-005453-4057qib7 3661 1 The the DT cord-005453-4057qib7 3661 2 patients patient NNS cord-005453-4057qib7 3661 3 were be VBD cord-005453-4057qib7 3661 4 classified classify VBN cord-005453-4057qib7 3661 5 into into IN cord-005453-4057qib7 3661 6 3 3 CD cord-005453-4057qib7 3661 7 groups group NNS cord-005453-4057qib7 3661 8 : : : cord-005453-4057qib7 3661 9 group group NN cord-005453-4057qib7 3661 10 A A NNP cord-005453-4057qib7 3661 11 ( ( -LRB- cord-005453-4057qib7 3661 12 n=33 n=33 NN cord-005453-4057qib7 3661 13 ; ; : cord-005453-4057qib7 3661 14 G G NNP cord-005453-4057qib7 3661 15 - - HYPH cord-005453-4057qib7 3661 16 CSF CSF NNP cord-005453-4057qib7 3661 17 since since IN cord-005453-4057qib7 3661 18 day day NN cord-005453-4057qib7 3661 19 +7 +7 . cord-005453-4057qib7 3661 20 without without IN cord-005453-4057qib7 3661 21 corticosteroid corticosteroid NN cord-005453-4057qib7 3661 22 ) ) -RRB- cord-005453-4057qib7 3661 23 , , , cord-005453-4057qib7 3661 24 group group NN cord-005453-4057qib7 3661 25 B B NNP cord-005453-4057qib7 3661 26 ( ( -LRB- cord-005453-4057qib7 3661 27 n=32 n=32 NNP cord-005453-4057qib7 3661 28 ; ; : cord-005453-4057qib7 3661 29 no no DT cord-005453-4057qib7 3661 30 G G NNP cord-005453-4057qib7 3661 31 - - HYPH cord-005453-4057qib7 3661 32 CSF CSF NNP cord-005453-4057qib7 3661 33 and and CC cord-005453-4057qib7 3661 34 no no DT cord-005453-4057qib7 3661 35 corticosteroid corticosteroid NN cord-005453-4057qib7 3661 36 ) ) -RRB- cord-005453-4057qib7 3661 37 , , , cord-005453-4057qib7 3661 38 group group NN cord-005453-4057qib7 3661 39 C C NNP cord-005453-4057qib7 3661 40 ( ( -LRB- cord-005453-4057qib7 3661 41 n=46 n=46 JJ cord-005453-4057qib7 3661 42 ; ; : cord-005453-4057qib7 3661 43 no no DT cord-005453-4057qib7 3661 44 G G NNP cord-005453-4057qib7 3661 45 - - HYPH cord-005453-4057qib7 3661 46 CSF CSF NNP cord-005453-4057qib7 3661 47 with with IN cord-005453-4057qib7 3661 48 prednisone prednisone NNP cord-005453-4057qib7 3661 49 0.5 0.5 CD cord-005453-4057qib7 3662 1 mg mg NNP cord-005453-4057qib7 3662 2 / / SYM cord-005453-4057qib7 3662 3 kg kg NNP cord-005453-4057qib7 3662 4 / / SYM cord-005453-4057qib7 3662 5 day day NN cord-005453-4057qib7 3662 6 since since IN cord-005453-4057qib7 3662 7 day day NN cord-005453-4057qib7 3662 8 +7 +7 . cord-005453-4057qib7 3662 9 until until IN cord-005453-4057qib7 3662 10 granulocyte granulocyte NN cord-005453-4057qib7 3662 11 recovery recovery NN cord-005453-4057qib7 3662 12 ) ) -RRB- cord-005453-4057qib7 3662 13 . . . cord-005453-4057qib7 3663 1 First first JJ cord-005453-4057qib7 3663 2 - - HYPH cord-005453-4057qib7 3663 3 line line NN cord-005453-4057qib7 3663 4 therapy therapy NN cord-005453-4057qib7 3663 5 at at IN cord-005453-4057qib7 3663 6 home home NN cord-005453-4057qib7 3663 7 of of IN cord-005453-4057qib7 3663 8 NF nf NN cord-005453-4057qib7 3663 9 was be VBD cord-005453-4057qib7 3663 10 piperacillin piperacillin NN cord-005453-4057qib7 3663 11 - - HYPH cord-005453-4057qib7 3663 12 tazobactam tazobactam NNP cord-005453-4057qib7 3664 1 4.5 4.5 CD cord-005453-4057qib7 3664 2 g/6h g/6h POS cord-005453-4057qib7 3664 3 i.v i.v NNP cord-005453-4057qib7 3664 4 . . . cord-005453-4057qib7 3665 1 using use VBG cord-005453-4057qib7 3665 2 a a DT cord-005453-4057qib7 3665 3 portable portable JJ cord-005453-4057qib7 3665 4 intermittent intermittent JJ cord-005453-4057qib7 3665 5 infusion infusion NN cord-005453-4057qib7 3665 6 pump pump NN cord-005453-4057qib7 3665 7 . . . cord-005453-4057qib7 3666 1 Fever fever NN cord-005453-4057qib7 3666 2 was be VBD cord-005453-4057qib7 3666 3 an an DT cord-005453-4057qib7 3666 4 indication indication NN cord-005453-4057qib7 3666 5 of of IN cord-005453-4057qib7 3666 6 immediate immediate JJ cord-005453-4057qib7 3666 7 medical medical JJ cord-005453-4057qib7 3666 8 consultation consultation NN cord-005453-4057qib7 3666 9 and and CC cord-005453-4057qib7 3666 10 those those DT cord-005453-4057qib7 3666 11 patients patient NNS cord-005453-4057qib7 3666 12 presenting present VBG cord-005453-4057qib7 3666 13 signs sign NNS cord-005453-4057qib7 3666 14 of of IN cord-005453-4057qib7 3666 15 focal focal JJ cord-005453-4057qib7 3666 16 infection infection NN cord-005453-4057qib7 3666 17 or or CC cord-005453-4057qib7 3666 18 severe severe JJ cord-005453-4057qib7 3666 19 sepsis sepsis NN cord-005453-4057qib7 3666 20 were be VBD cord-005453-4057qib7 3666 21 admitted admit VBN cord-005453-4057qib7 3666 22 . . . cord-005453-4057qib7 3667 1 Other other JJ cord-005453-4057qib7 3667 2 indications indication NNS cord-005453-4057qib7 3667 3 for for IN cord-005453-4057qib7 3667 4 readmission readmission NN cord-005453-4057qib7 3667 5 were be VBD cord-005453-4057qib7 3667 6 : : : cord-005453-4057qib7 3667 7 willingness willingness NN cord-005453-4057qib7 3667 8 of of IN cord-005453-4057qib7 3667 9 the the DT cord-005453-4057qib7 3667 10 patient patient NN cord-005453-4057qib7 3667 11 or or CC cord-005453-4057qib7 3667 12 caregiver caregiver NN cord-005453-4057qib7 3667 13 , , , cord-005453-4057qib7 3667 14 uncontrolled uncontrolled JJ cord-005453-4057qib7 3667 15 nausea nausea NN cord-005453-4057qib7 3667 16 , , , cord-005453-4057qib7 3667 17 vomiting vomiting NN cord-005453-4057qib7 3667 18 or or CC cord-005453-4057qib7 3667 19 diarrhoea diarrhoea NN cord-005453-4057qib7 3667 20 , , , cord-005453-4057qib7 3667 21 and and CC cord-005453-4057qib7 3667 22 mucositis mucositis NNP cord-005453-4057qib7 3667 23 requiring require VBG cord-005453-4057qib7 3667 24 total total JJ cord-005453-4057qib7 3667 25 parenteral parenteral JJ cord-005453-4057qib7 3667 26 nutrition nutrition NN cord-005453-4057qib7 3667 27 or or CC cord-005453-4057qib7 3667 28 i.v i.v NNP cord-005453-4057qib7 3667 29 . . NNP cord-005453-4057qib7 3667 30 morphics morphic NNS cord-005453-4057qib7 3667 31 . . . cord-005453-4057qib7 3668 1 Results result NNS cord-005453-4057qib7 3668 2 : : : cord-005453-4057qib7 3669 1 The the DT cord-005453-4057qib7 3669 2 main main JJ cord-005453-4057qib7 3669 3 characteristics characteristic NNS cord-005453-4057qib7 3669 4 of of IN cord-005453-4057qib7 3669 5 the the DT cord-005453-4057qib7 3669 6 patients patient NNS cord-005453-4057qib7 3669 7 and and CC cord-005453-4057qib7 3669 8 outcomes outcome NNS cord-005453-4057qib7 3669 9 are be VBP cord-005453-4057qib7 3669 10 shown show VBN cord-005453-4057qib7 3669 11 in in IN cord-005453-4057qib7 3669 12 table table NN cord-005453-4057qib7 3669 13 1 1 CD cord-005453-4057qib7 3669 14 . . . cord-005453-4057qib7 3670 1 There there EX cord-005453-4057qib7 3670 2 were be VBD cord-005453-4057qib7 3670 3 no no DT cord-005453-4057qib7 3670 4 differences difference NNS cord-005453-4057qib7 3670 5 between between IN cord-005453-4057qib7 3670 6 groups group NNS cord-005453-4057qib7 3670 7 regarding regard VBG cord-005453-4057qib7 3670 8 age age NN cord-005453-4057qib7 3670 9 , , , cord-005453-4057qib7 3670 10 gender gender NN cord-005453-4057qib7 3670 11 , , , cord-005453-4057qib7 3670 12 immunological immunological JJ cord-005453-4057qib7 3670 13 subtype subtype NN cord-005453-4057qib7 3670 14 , , , cord-005453-4057qib7 3670 15 response response NN cord-005453-4057qib7 3670 16 before before IN cord-005453-4057qib7 3670 17 ASCT ASCT NNP cord-005453-4057qib7 3670 18 , , , cord-005453-4057qib7 3670 19 HCT HCT NNP cord-005453-4057qib7 3670 20 - - HYPH cord-005453-4057qib7 3670 21 CI CI NNP cord-005453-4057qib7 3670 22 , , , cord-005453-4057qib7 3670 23 and and CC cord-005453-4057qib7 3670 24 CD34 CD34 NNP cord-005453-4057qib7 3670 25 cell cell NN cord-005453-4057qib7 3670 26 dose dose NN cord-005453-4057qib7 3670 27 infused infuse VBN cord-005453-4057qib7 3670 28 . . . cord-005453-4057qib7 3671 1 There there EX cord-005453-4057qib7 3671 2 were be VBD cord-005453-4057qib7 3671 3 more more JJR cord-005453-4057qib7 3671 4 patients patient NNS cord-005453-4057qib7 3671 5 with with IN cord-005453-4057qib7 3671 6 advanced advanced JJ cord-005453-4057qib7 3671 7 disease disease NN cord-005453-4057qib7 3671 8 ( ( -LRB- cord-005453-4057qib7 3671 9 ISS ISS NNP cord-005453-4057qib7 3671 10 III III NNP cord-005453-4057qib7 3671 11 ) ) -RRB- cord-005453-4057qib7 3671 12 in in IN cord-005453-4057qib7 3671 13 group group NN cord-005453-4057qib7 3671 14 C c NN cord-005453-4057qib7 3671 15 compared compare VBN cord-005453-4057qib7 3671 16 to to IN cord-005453-4057qib7 3671 17 group group NN cord-005453-4057qib7 3671 18 A a NN cord-005453-4057qib7 3671 19 ( ( -LRB- cord-005453-4057qib7 3671 20 19.5 19.5 CD cord-005453-4057qib7 3671 21 % % NN cord-005453-4057qib7 3671 22 vs. vs. IN cord-005453-4057qib7 3671 23 6.1 6.1 CD cord-005453-4057qib7 3671 24 % % NN cord-005453-4057qib7 3671 25 ; ; : cord-005453-4057qib7 3671 26 P=0.003 P=0.003 NNP cord-005453-4057qib7 3671 27 ) ) -RRB- cord-005453-4057qib7 3671 28 . . . cord-005453-4057qib7 3672 1 The the DT cord-005453-4057qib7 3672 2 duration duration NN cord-005453-4057qib7 3672 3 of of IN cord-005453-4057qib7 3672 4 neutropenia neutropenia NN cord-005453-4057qib7 3672 5 was be VBD cord-005453-4057qib7 3672 6 longer long JJR cord-005453-4057qib7 3672 7 in in IN cord-005453-4057qib7 3672 8 those those DT cord-005453-4057qib7 3672 9 groups group NNS cord-005453-4057qib7 3672 10 that that WDT cord-005453-4057qib7 3672 11 did do VBD cord-005453-4057qib7 3672 12 not not RB cord-005453-4057qib7 3672 13 receive receive VB cord-005453-4057qib7 3672 14 G G NNP cord-005453-4057qib7 3672 15 - - HYPH cord-005453-4057qib7 3672 16 CSF CSF NNP cord-005453-4057qib7 3672 17 ( ( -LRB- cord-005453-4057qib7 3672 18 A a NN cord-005453-4057qib7 3672 19 : : : cord-005453-4057qib7 3672 20 8 8 CD cord-005453-4057qib7 3672 21 days day NNS cord-005453-4057qib7 3672 22 , , , cord-005453-4057qib7 3672 23 B b NN cord-005453-4057qib7 3672 24 : : : cord-005453-4057qib7 3672 25 11 11 CD cord-005453-4057qib7 3672 26 days day NNS cord-005453-4057qib7 3672 27 , , , cord-005453-4057qib7 3672 28 C c NN cord-005453-4057qib7 3672 29 : : : cord-005453-4057qib7 3672 30 10 10 CD cord-005453-4057qib7 3672 31 days day NNS cord-005453-4057qib7 3672 32 ; ; : cord-005453-4057qib7 3672 33 P p NN cord-005453-4057qib7 3672 34 < < XX cord-005453-4057qib7 3672 35 0.01 0.01 CD cord-005453-4057qib7 3672 36 ) ) -RRB- cord-005453-4057qib7 3672 37 . . . cord-005453-4057qib7 3673 1 Comparing compare VBG cord-005453-4057qib7 3673 2 group group NN cord-005453-4057qib7 3673 3 A A NNP cord-005453-4057qib7 3673 4 with with IN cord-005453-4057qib7 3673 5 group group NN cord-005453-4057qib7 3673 6 C C NNP cord-005453-4057qib7 3673 7 , , , cord-005453-4057qib7 3673 8 we -PRON- PRP cord-005453-4057qib7 3673 9 observed observe VBD cord-005453-4057qib7 3673 10 that that IN cord-005453-4057qib7 3673 11 the the DT cord-005453-4057qib7 3673 12 incidence incidence NN cord-005453-4057qib7 3673 13 of of IN cord-005453-4057qib7 3673 14 NF nf NN cord-005453-4057qib7 3673 15 and and CC cord-005453-4057qib7 3673 16 the the DT cord-005453-4057qib7 3673 17 readmissions readmission NNS cord-005453-4057qib7 3673 18 rates rate NNS cord-005453-4057qib7 3673 19 were be VBD cord-005453-4057qib7 3673 20 lower low JJR cord-005453-4057qib7 3673 21 in in IN cord-005453-4057qib7 3673 22 group group NN cord-005453-4057qib7 3673 23 C C NNP cord-005453-4057qib7 3673 24 ( ( -LRB- cord-005453-4057qib7 3673 25 NF nf NN cord-005453-4057qib7 3673 26 : : : cord-005453-4057qib7 3673 27 57.6 57.6 CD cord-005453-4057qib7 3673 28 % % NN cord-005453-4057qib7 3673 29 vs. vs. IN cord-005453-4057qib7 3673 30 23.9 23.9 CD cord-005453-4057qib7 3673 31 % % NN cord-005453-4057qib7 3673 32 ; ; : cord-005453-4057qib7 3673 33 P=0.002 p=0.002 NN cord-005453-4057qib7 3673 34 ; ; , cord-005453-4057qib7 3673 35 relative relative JJ cord-005453-4057qib7 3673 36 risk risk NN cord-005453-4057qib7 3673 37 reduction reduction NN cord-005453-4057qib7 3673 38 : : : cord-005453-4057qib7 3673 39 0.41 0.41 CD cord-005453-4057qib7 3673 40 , , , cord-005453-4057qib7 3673 41 and and CC cord-005453-4057qib7 3673 42 number number NN cord-005453-4057qib7 3673 43 needed need VBN cord-005453-4057qib7 3673 44 to to TO cord-005453-4057qib7 3673 45 treat treat VB cord-005453-4057qib7 3673 46 2.97 2.97 CD cord-005453-4057qib7 3673 47 ; ; : cord-005453-4057qib7 3673 48 readmissions readmission NNS cord-005453-4057qib7 3673 49 : : : cord-005453-4057qib7 3673 50 12.1 12.1 CD cord-005453-4057qib7 3673 51 % % NN cord-005453-4057qib7 3673 52 vs. vs. IN cord-005453-4057qib7 3673 53 2.2 2.2 CD cord-005453-4057qib7 3673 54 % % NN cord-005453-4057qib7 3673 55 ; ; : cord-005453-4057qib7 3673 56 P=0.07 P=0.07 NNS cord-005453-4057qib7 3673 57 , , , cord-005453-4057qib7 3673 58 respectively respectively RB cord-005453-4057qib7 3673 59 ) ) -RRB- cord-005453-4057qib7 3673 60 . . . cord-005453-4057qib7 3674 1 The the DT cord-005453-4057qib7 3674 2 10-day 10-day CD cord-005453-4057qib7 3674 3 cumulative cumulative JJ cord-005453-4057qib7 3674 4 incidence incidence NN cord-005453-4057qib7 3674 5 of of IN cord-005453-4057qib7 3674 6 NF NF NNP cord-005453-4057qib7 3674 7 were be VBD cord-005453-4057qib7 3674 8 54.5 54.5 CD cord-005453-4057qib7 3674 9 % % NN cord-005453-4057qib7 3674 10 in in IN cord-005453-4057qib7 3674 11 group group NN cord-005453-4057qib7 3674 12 A A NNP cord-005453-4057qib7 3674 13 , , , cord-005453-4057qib7 3674 14 40.6 40.6 CD cord-005453-4057qib7 3674 15 % % NN cord-005453-4057qib7 3674 16 in in IN cord-005453-4057qib7 3674 17 group group NN cord-005453-4057qib7 3674 18 B B NNP cord-005453-4057qib7 3674 19 , , , cord-005453-4057qib7 3674 20 and and CC cord-005453-4057qib7 3674 21 23.9 23.9 CD cord-005453-4057qib7 3674 22 % % NN cord-005453-4057qib7 3674 23 in in IN cord-005453-4057qib7 3674 24 group group NN cord-005453-4057qib7 3674 25 C c NN cord-005453-4057qib7 3674 26 ; ; : cord-005453-4057qib7 3674 27 P=0.009 p=0.009 NN cord-005453-4057qib7 3674 28 . . . cord-005453-4057qib7 3675 1 The the DT cord-005453-4057qib7 3675 2 non non JJ cord-005453-4057qib7 3675 3 - - JJ cord-005453-4057qib7 3675 4 administration administration JJ cord-005453-4057qib7 3675 5 of of IN cord-005453-4057qib7 3675 6 G G NNP cord-005453-4057qib7 3675 7 - - HYPH cord-005453-4057qib7 3675 8 CSF CSF NNP cord-005453-4057qib7 3675 9 with with IN cord-005453-4057qib7 3675 10 the the DT cord-005453-4057qib7 3675 11 addition addition NN cord-005453-4057qib7 3675 12 of of IN cord-005453-4057qib7 3675 13 prophylactic prophylactic JJ cord-005453-4057qib7 3675 14 corticosteroid corticosteroid NNP cord-005453-4057qib7 3675 15 did do VBD cord-005453-4057qib7 3675 16 not not RB cord-005453-4057qib7 3675 17 modify modify VB cord-005453-4057qib7 3675 18 the the DT cord-005453-4057qib7 3675 19 incidence incidence NN cord-005453-4057qib7 3675 20 and and CC cord-005453-4057qib7 3675 21 grade grade NN cord-005453-4057qib7 3675 22 of of IN cord-005453-4057qib7 3675 23 mucositis mucositis NNP cord-005453-4057qib7 3675 24 , , , cord-005453-4057qib7 3675 25 the the DT cord-005453-4057qib7 3675 26 first first JJ cord-005453-4057qib7 3675 27 day day NN cord-005453-4057qib7 3675 28 and and CC cord-005453-4057qib7 3675 29 duration duration NN cord-005453-4057qib7 3675 30 of of IN cord-005453-4057qib7 3675 31 fever fever NN cord-005453-4057qib7 3675 32 , , , cord-005453-4057qib7 3675 33 nor nor CC cord-005453-4057qib7 3675 34 the the DT cord-005453-4057qib7 3675 35 number number NN cord-005453-4057qib7 3675 36 of of IN cord-005453-4057qib7 3675 37 bacterial bacterial JJ cord-005453-4057qib7 3675 38 infections infection NNS cord-005453-4057qib7 3675 39 documented document VBN cord-005453-4057qib7 3675 40 . . . cord-005453-4057qib7 3676 1 In in IN cord-005453-4057qib7 3676 2 the the DT cord-005453-4057qib7 3676 3 multivariate multivariate JJ cord-005453-4057qib7 3676 4 analysis analysis NN cord-005453-4057qib7 3676 5 , , , cord-005453-4057qib7 3676 6 this this DT cord-005453-4057qib7 3676 7 combination combination NN cord-005453-4057qib7 3676 8 ( ( -LRB- cord-005453-4057qib7 3676 9 no no DT cord-005453-4057qib7 3676 10 G G NNP cord-005453-4057qib7 3676 11 - - HYPH cord-005453-4057qib7 3676 12 CSF CSF NNP cord-005453-4057qib7 3676 13 with with IN cord-005453-4057qib7 3676 14 corticosteroid corticosteroid NNP cord-005453-4057qib7 3676 15 ) ) -RRB- cord-005453-4057qib7 3676 16 maintained maintain VBD cord-005453-4057qib7 3676 17 its -PRON- PRP$ cord-005453-4057qib7 3676 18 protective protective JJ cord-005453-4057qib7 3676 19 effect effect NN cord-005453-4057qib7 3676 20 for for IN cord-005453-4057qib7 3676 21 the the DT cord-005453-4057qib7 3676 22 development development NN cord-005453-4057qib7 3676 23 of of IN cord-005453-4057qib7 3676 24 NF nf NN cord-005453-4057qib7 3676 25 and and CC cord-005453-4057qib7 3676 26 hospital hospital NN cord-005453-4057qib7 3676 27 readmission readmission NN cord-005453-4057qib7 3676 28 ( ( -LRB- cord-005453-4057qib7 3676 29 OR or CC cord-005453-4057qib7 3676 30 0.07 0.07 CD cord-005453-4057qib7 3676 31 ; ; : cord-005453-4057qib7 3676 32 P=0.001 P=0.001 NNS cord-005453-4057qib7 3676 33 and and CC cord-005453-4057qib7 3676 34 OR or CC cord-005453-4057qib7 3676 35 0.07 0.07 CD cord-005453-4057qib7 3676 36 ; ; : cord-005453-4057qib7 3676 37 P=0.05 p=0.05 JJ cord-005453-4057qib7 3676 38 , , , cord-005453-4057qib7 3676 39 respectively respectively RB cord-005453-4057qib7 3676 40 ) ) -RRB- cord-005453-4057qib7 3676 41 . . . cord-005453-4057qib7 3677 1 Conclusions conclusion NNS cord-005453-4057qib7 3677 2 : : : cord-005453-4057qib7 3678 1 The the DT cord-005453-4057qib7 3678 2 non non JJ cord-005453-4057qib7 3678 3 - - JJ cord-005453-4057qib7 3678 4 use use NN cord-005453-4057qib7 3678 5 of of IN cord-005453-4057qib7 3678 6 G G NNP cord-005453-4057qib7 3678 7 - - HYPH cord-005453-4057qib7 3678 8 CSF CSF NNP cord-005453-4057qib7 3678 9 and and CC cord-005453-4057qib7 3678 10 the the DT cord-005453-4057qib7 3678 11 addition addition NN cord-005453-4057qib7 3678 12 of of IN cord-005453-4057qib7 3678 13 prophylactic prophylactic JJ cord-005453-4057qib7 3678 14 corticosteroid corticosteroid NN cord-005453-4057qib7 3678 15 in in IN cord-005453-4057qib7 3678 16 MM MM NNP cord-005453-4057qib7 3678 17 patients patient NNS cord-005453-4057qib7 3678 18 managed manage VBN cord-005453-4057qib7 3678 19 at at IN cord-005453-4057qib7 3678 20 home home NN cord-005453-4057qib7 3678 21 after after IN cord-005453-4057qib7 3678 22 ASCT ASCT NNP cord-005453-4057qib7 3678 23 minimize minimize VB cord-005453-4057qib7 3678 24 the the DT cord-005453-4057qib7 3678 25 incidence incidence NN cord-005453-4057qib7 3678 26 of of IN cord-005453-4057qib7 3678 27 non non JJ cord-005453-4057qib7 3678 28 - - JJ cord-005453-4057qib7 3678 29 infectious infectious JJ cord-005453-4057qib7 3678 30 fever fever NN cord-005453-4057qib7 3678 31 and and CC cord-005453-4057qib7 3678 32 optimize optimize VB cord-005453-4057qib7 3678 33 hospital hospital NN cord-005453-4057qib7 3678 34 resources resource NNS cord-005453-4057qib7 3678 35 by by IN cord-005453-4057qib7 3678 36 reducing reduce VBG cord-005453-4057qib7 3678 37 hospital hospital NN cord-005453-4057qib7 3678 38 readmissions readmission NNS cord-005453-4057qib7 3678 39 . . . cord-005453-4057qib7 3679 1 Disclosure disclosure NN cord-005453-4057qib7 3679 2 : : : cord-005453-4057qib7 3679 3 Nothing nothing NN cord-005453-4057qib7 3679 4 to to TO cord-005453-4057qib7 3679 5 declare declare VB cord-005453-4057qib7 3679 6 . . . cord-005453-4057qib7 3680 1 Background background NN cord-005453-4057qib7 3680 2 : : : cord-005453-4057qib7 3681 1 Antibody antibody NN cord-005453-4057qib7 3681 2 titers titer NNS cord-005453-4057qib7 3681 3 to to IN cord-005453-4057qib7 3681 4 vaccine vaccine NN cord-005453-4057qib7 3681 5 - - HYPH cord-005453-4057qib7 3681 6 preventable preventable JJ cord-005453-4057qib7 3681 7 diseases disease NNS cord-005453-4057qib7 3681 8 decline decline VBP cord-005453-4057qib7 3681 9 during during IN cord-005453-4057qib7 3681 10 the the DT cord-005453-4057qib7 3681 11 1 1 CD cord-005453-4057qib7 3681 12 - - SYM cord-005453-4057qib7 3681 13 10 10 CD cord-005453-4057qib7 3681 14 years year NNS cord-005453-4057qib7 3681 15 after after IN cord-005453-4057qib7 3681 16 allogeneic allogeneic JJ cord-005453-4057qib7 3681 17 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 3681 18 Stem Stem NNP cord-005453-4057qib7 3681 19 Cell cell NN cord-005453-4057qib7 3681 20 Transplantation transplantation NN cord-005453-4057qib7 3681 21 ( ( -LRB- cord-005453-4057qib7 3681 22 HSCT HSCT NNP cord-005453-4057qib7 3681 23 ) ) -RRB- cord-005453-4057qib7 3681 24 if if IN cord-005453-4057qib7 3681 25 the the DT cord-005453-4057qib7 3681 26 recipient recipient NN cord-005453-4057qib7 3681 27 is be VBZ cord-005453-4057qib7 3681 28 not not RB cord-005453-4057qib7 3681 29 revaccinated revaccinate VBN cord-005453-4057qib7 3681 30 . . . cord-005453-4057qib7 3682 1 It -PRON- PRP cord-005453-4057qib7 3682 2 is be VBZ cord-005453-4057qib7 3682 3 therefore therefore RB cord-005453-4057qib7 3682 4 considered consider VBN cord-005453-4057qib7 3682 5 best good JJS cord-005453-4057qib7 3682 6 practice practice NN cord-005453-4057qib7 3682 7 to to TO cord-005453-4057qib7 3682 8 try try VB cord-005453-4057qib7 3682 9 to to TO cord-005453-4057qib7 3682 10 offer offer VB cord-005453-4057qib7 3682 11 HSCT HSCT NNP cord-005453-4057qib7 3682 12 recipients recipient NNS cord-005453-4057qib7 3682 13 the the DT cord-005453-4057qib7 3682 14 same same JJ cord-005453-4057qib7 3682 15 level level NN cord-005453-4057qib7 3682 16 of of IN cord-005453-4057qib7 3682 17 protection protection NN cord-005453-4057qib7 3682 18 against against IN cord-005453-4057qib7 3682 19 all all DT cord-005453-4057qib7 3682 20 vaccine vaccine NN cord-005453-4057qib7 3682 21 preventable preventable JJ cord-005453-4057qib7 3682 22 diseases disease NNS cord-005453-4057qib7 3682 23 as as IN cord-005453-4057qib7 3682 24 the the DT cord-005453-4057qib7 3682 25 general general JJ cord-005453-4057qib7 3682 26 population population NN cord-005453-4057qib7 3682 27 . . . cord-005453-4057qib7 3683 1 Few few JJ cord-005453-4057qib7 3683 2 data datum NNS cord-005453-4057qib7 3683 3 in in IN cord-005453-4057qib7 3683 4 the the DT cord-005453-4057qib7 3683 5 literature literature NN cord-005453-4057qib7 3683 6 are be VBP cord-005453-4057qib7 3683 7 available available JJ cord-005453-4057qib7 3683 8 concerning concern VBG cord-005453-4057qib7 3683 9 vaccine vaccine NN cord-005453-4057qib7 3683 10 - - HYPH cord-005453-4057qib7 3683 11 related relate VBN cord-005453-4057qib7 3683 12 problems problem NNS cord-005453-4057qib7 3683 13 in in IN cord-005453-4057qib7 3683 14 HSCT HSCT NNP cord-005453-4057qib7 3683 15 recipients recipient NNS cord-005453-4057qib7 3683 16 . . . cord-005453-4057qib7 3684 1 We -PRON- PRP cord-005453-4057qib7 3684 2 performed perform VBD cord-005453-4057qib7 3684 3 a a DT cord-005453-4057qib7 3684 4 farmacovigilance farmacovigilance NN cord-005453-4057qib7 3684 5 evaluation evaluation NN cord-005453-4057qib7 3684 6 in in IN cord-005453-4057qib7 3684 7 a a DT cord-005453-4057qib7 3684 8 cohort cohort NN cord-005453-4057qib7 3684 9 of of IN cord-005453-4057qib7 3684 10 allotransplanted allotransplante VBN cord-005453-4057qib7 3684 11 patients patient NNS cord-005453-4057qib7 3684 12 followed follow VBD cord-005453-4057qib7 3684 13 in in IN cord-005453-4057qib7 3684 14 our -PRON- PRP$ cord-005453-4057qib7 3684 15 clinic clinic NN cord-005453-4057qib7 3684 16 during during IN cord-005453-4057qib7 3684 17 a a DT cord-005453-4057qib7 3684 18 1 1 CD cord-005453-4057qib7 3684 19 year year NN cord-005453-4057qib7 3684 20 period period NN cord-005453-4057qib7 3684 21 . . . cord-005453-4057qib7 3685 1 Methods method NNS cord-005453-4057qib7 3685 2 : : : cord-005453-4057qib7 3686 1 From from IN cord-005453-4057qib7 3686 2 October October NNP cord-005453-4057qib7 3686 3 2017 2017 CD cord-005453-4057qib7 3686 4 to to IN cord-005453-4057qib7 3686 5 November November NNP cord-005453-4057qib7 3686 6 2018 2018 CD cord-005453-4057qib7 3686 7 we -PRON- PRP cord-005453-4057qib7 3686 8 administered administer VBD cord-005453-4057qib7 3686 9 a a DT cord-005453-4057qib7 3686 10 list list NN cord-005453-4057qib7 3686 11 of of IN cord-005453-4057qib7 3686 12 recommended recommend VBN cord-005453-4057qib7 3686 13 vaccines vaccine NNS cord-005453-4057qib7 3686 14 to to IN cord-005453-4057qib7 3686 15 49 49 CD cord-005453-4057qib7 3686 16 HSCT HSCT NNP cord-005453-4057qib7 3686 17 recipients recipient NNS cord-005453-4057qib7 3686 18 attending attend VBG cord-005453-4057qib7 3686 19 our -PRON- PRP$ cord-005453-4057qib7 3686 20 routine routine JJ cord-005453-4057qib7 3686 21 out out RP cord-005453-4057qib7 3686 22 patient patient JJ cord-005453-4057qib7 3686 23 clinic clinic NN cord-005453-4057qib7 3686 24 who who WP cord-005453-4057qib7 3686 25 fulfilled fulfil VBD cord-005453-4057qib7 3686 26 the the DT cord-005453-4057qib7 3686 27 following follow VBG cord-005453-4057qib7 3686 28 criteria criterion NNS cord-005453-4057qib7 3686 29 : : : cord-005453-4057qib7 3687 1 CD4 CD4 NNP cord-005453-4057qib7 3687 2 T T NNP cord-005453-4057qib7 3687 3 cells>200 cells>200 NNP cord-005453-4057qib7 3687 4 / / SYM cord-005453-4057qib7 3687 5 μl μl XX cord-005453-4057qib7 3688 1 , , , cord-005453-4057qib7 3688 2 CD19 CD19 NNP cord-005453-4057qib7 3688 3 B B NNP cord-005453-4057qib7 3688 4 cells>20/ cells>20/ NN cord-005453-4057qib7 3689 1 μl μl IN cord-005453-4057qib7 3690 1 , , , cord-005453-4057qib7 3690 2 anti anti JJ cord-005453-4057qib7 3690 3 - - JJ cord-005453-4057qib7 3690 4 CD20 cd20 JJ cord-005453-4057qib7 3690 5 antibody antibody NN cord-005453-4057qib7 3691 1 infusion>6 infusion>6 JJ cord-005453-4057qib7 3691 2 months month NNS cord-005453-4057qib7 3691 3 , , , cord-005453-4057qib7 3691 4 IVIG IVIG NNP cord-005453-4057qib7 3691 5 therapy>2 therapy>2 NNP cord-005453-4057qib7 3691 6 months month NNS cord-005453-4057qib7 3691 7 , , , cord-005453-4057qib7 3691 8 no no DT cord-005453-4057qib7 3691 9 active active JJ cord-005453-4057qib7 3691 10 and and CC cord-005453-4057qib7 3691 11 severe severe JJ cord-005453-4057qib7 3691 12 Graft graft NN cord-005453-4057qib7 3691 13 - - HYPH cord-005453-4057qib7 3691 14 versus versus IN cord-005453-4057qib7 3691 15 - - HYPH cord-005453-4057qib7 3691 16 Host Host NNP cord-005453-4057qib7 3691 17 - - HYPH cord-005453-4057qib7 3691 18 Disease Disease NNP cord-005453-4057qib7 3691 19 ( ( -LRB- cord-005453-4057qib7 3691 20 GvHD GvHD NNP cord-005453-4057qib7 3691 21 ) ) -RRB- cord-005453-4057qib7 3691 22 , , , cord-005453-4057qib7 3691 23 no no DT cord-005453-4057qib7 3691 24 chemotherapy chemotherapy NN cord-005453-4057qib7 3691 25 or or CC cord-005453-4057qib7 3691 26 biological biological JJ cord-005453-4057qib7 3691 27 therapeutic therapeutic JJ cord-005453-4057qib7 3691 28 agents agent NNS cord-005453-4057qib7 3691 29 on on IN cord-005453-4057qib7 3691 30 going go VBG cord-005453-4057qib7 3691 31 . . . cord-005453-4057qib7 3692 1 Vaccines vaccine NNS cord-005453-4057qib7 3692 2 suggested suggest VBN cord-005453-4057qib7 3692 3 were be VBD cord-005453-4057qib7 3692 4 Influenza Influenza NNP cord-005453-4057qib7 3692 5 , , , cord-005453-4057qib7 3692 6 Pneumococcal Pneumococcal NNP cord-005453-4057qib7 3692 7 conjugate conjugate NN cord-005453-4057qib7 3692 8 ( ( -LRB- cord-005453-4057qib7 3692 9 PCV13 PCV13 NNP cord-005453-4057qib7 3692 10 ) ) -RRB- cord-005453-4057qib7 3692 11 , , , cord-005453-4057qib7 3692 12 Polio Polio NNP cord-005453-4057qib7 3692 13 ( ( -LRB- cord-005453-4057qib7 3692 14 inactivated inactivate VBN cord-005453-4057qib7 3692 15 polio polio NN cord-005453-4057qib7 3692 16 vaccine vaccine NN cord-005453-4057qib7 3692 17 ) ) -RRB- cord-005453-4057qib7 3692 18 , , , cord-005453-4057qib7 3692 19 Diphteria Diphteria NNP cord-005453-4057qib7 3692 20 , , , cord-005453-4057qib7 3692 21 Tetanus Tetanus NNP cord-005453-4057qib7 3692 22 , , , cord-005453-4057qib7 3692 23 Acellular Acellular NNP cord-005453-4057qib7 3692 24 pertussis pertussis NN cord-005453-4057qib7 3692 25 , , , cord-005453-4057qib7 3692 26 Hepatitis Hepatitis NNP cord-005453-4057qib7 3692 27 B B NNP cord-005453-4057qib7 3692 28 , , , cord-005453-4057qib7 3692 29 Hepatitis Hepatitis NNP cord-005453-4057qib7 3692 30 A A NNP cord-005453-4057qib7 3692 31 , , , cord-005453-4057qib7 3692 32 Haemophilus haemophilus JJ cord-005453-4057qib7 3692 33 influenzae influenzae NN cord-005453-4057qib7 3692 34 type type NN cord-005453-4057qib7 3692 35 B b NN cord-005453-4057qib7 3692 36 , , , cord-005453-4057qib7 3692 37 Meningococcal meningococcal JJ cord-005453-4057qib7 3692 38 quadrivalent quadrivalent NN cord-005453-4057qib7 3692 39 ( ( -LRB- cord-005453-4057qib7 3692 40 MCV4 MCV4 NNP cord-005453-4057qib7 3692 41 ) ) -RRB- cord-005453-4057qib7 3692 42 , , , cord-005453-4057qib7 3692 43 Human human JJ cord-005453-4057qib7 3692 44 papillomavirus papillomavirus NN cord-005453-4057qib7 3692 45 , , , cord-005453-4057qib7 3692 46 Meningococcal Meningococcal NNP cord-005453-4057qib7 3692 47 B B NNP cord-005453-4057qib7 3692 48 , , , cord-005453-4057qib7 3692 49 Measles Measles NNP cord-005453-4057qib7 3692 50 - - HYPH cord-005453-4057qib7 3692 51 Mumps Mumps NNP cord-005453-4057qib7 3692 52 - - HYPH cord-005453-4057qib7 3692 53 Rubella Rubella NNP cord-005453-4057qib7 3692 54 ( ( -LRB- cord-005453-4057qib7 3692 55 MMR MMR NNP cord-005453-4057qib7 3692 56 ) ) -RRB- cord-005453-4057qib7 3692 57 , , , cord-005453-4057qib7 3692 58 Varicella Varicella NNP cord-005453-4057qib7 3692 59 . . . cord-005453-4057qib7 3693 1 Live live JJ cord-005453-4057qib7 3693 2 vaccines vaccine NNS cord-005453-4057qib7 3693 3 ( ( -LRB- cord-005453-4057qib7 3693 4 MMR MMR NNP cord-005453-4057qib7 3693 5 and and CC cord-005453-4057qib7 3693 6 Varicella Varicella NNP cord-005453-4057qib7 3693 7 ) ) -RRB- cord-005453-4057qib7 3693 8 were be VBD cord-005453-4057qib7 3693 9 not not RB cord-005453-4057qib7 3693 10 recommended recommend VBN cord-005453-4057qib7 3693 11 before before IN cord-005453-4057qib7 3693 12 2 2 CD cord-005453-4057qib7 3693 13 years year NNS cord-005453-4057qib7 3693 14 after after IN cord-005453-4057qib7 3693 15 HSCT HSCT NNP cord-005453-4057qib7 3693 16 and and CC cord-005453-4057qib7 3693 17 in in IN cord-005453-4057qib7 3693 18 patients patient NNS cord-005453-4057qib7 3693 19 with with IN cord-005453-4057qib7 3693 20 chronic chronic JJ cord-005453-4057qib7 3693 21 GvHD GvHD NNP cord-005453-4057qib7 3693 22 . . . cord-005453-4057qib7 3694 1 All all PDT cord-005453-4057qib7 3694 2 the the DT cord-005453-4057qib7 3694 3 patients patient NNS cord-005453-4057qib7 3694 4 were be VBD cord-005453-4057qib7 3694 5 asked ask VBN cord-005453-4057qib7 3694 6 to to TO cord-005453-4057qib7 3694 7 take take VB cord-005453-4057qib7 3694 8 the the DT cord-005453-4057qib7 3694 9 list list NN cord-005453-4057qib7 3694 10 to to IN cord-005453-4057qib7 3694 11 the the DT cord-005453-4057qib7 3694 12 local local JJ cord-005453-4057qib7 3694 13 health health NN cord-005453-4057qib7 3694 14 facilities facility NNS cord-005453-4057qib7 3694 15 in in IN cord-005453-4057qib7 3694 16 order order NN cord-005453-4057qib7 3694 17 to to TO cord-005453-4057qib7 3694 18 have have VB cord-005453-4057qib7 3694 19 the the DT cord-005453-4057qib7 3694 20 vaccines vaccine NNS cord-005453-4057qib7 3694 21 injected inject VBN cord-005453-4057qib7 3694 22 and and CC cord-005453-4057qib7 3694 23 a a DT cord-005453-4057qib7 3694 24 vaccination vaccination NN cord-005453-4057qib7 3694 25 table table NN cord-005453-4057qib7 3694 26 arranged arrange VBN cord-005453-4057qib7 3694 27 with with IN cord-005453-4057qib7 3694 28 the the DT cord-005453-4057qib7 3694 29 doses dose NNS cord-005453-4057qib7 3694 30 already already RB cord-005453-4057qib7 3694 31 received receive VBN cord-005453-4057qib7 3694 32 and and CC cord-005453-4057qib7 3694 33 those those DT cord-005453-4057qib7 3694 34 to to TO cord-005453-4057qib7 3694 35 receive receive VB cord-005453-4057qib7 3694 36 . . . cord-005453-4057qib7 3695 1 We -PRON- PRP cord-005453-4057qib7 3695 2 checked check VBD cord-005453-4057qib7 3695 3 the the DT cord-005453-4057qib7 3695 4 vaccination vaccination NN cord-005453-4057qib7 3695 5 tables table NNS cord-005453-4057qib7 3695 6 at at IN cord-005453-4057qib7 3695 7 each each DT cord-005453-4057qib7 3695 8 visit visit NN cord-005453-4057qib7 3695 9 and and CC cord-005453-4057qib7 3695 10 monitored monitor VBD cord-005453-4057qib7 3695 11 potential potential JJ cord-005453-4057qib7 3695 12 side side NN cord-005453-4057qib7 3695 13 effects effect NNS cord-005453-4057qib7 3695 14 and and CC cord-005453-4057qib7 3695 15 GvHD gvhd NN cord-005453-4057qib7 3695 16 status status NN cord-005453-4057qib7 3695 17 at at IN cord-005453-4057qib7 3695 18 3 3 CD cord-005453-4057qib7 3695 19 , , , cord-005453-4057qib7 3695 20 6 6 CD cord-005453-4057qib7 3695 21 , , , cord-005453-4057qib7 3695 22 and and CC cord-005453-4057qib7 3695 23 12 12 CD cord-005453-4057qib7 3695 24 months month NNS cord-005453-4057qib7 3695 25 after after IN cord-005453-4057qib7 3695 26 the the DT cord-005453-4057qib7 3695 27 first first JJ cord-005453-4057qib7 3695 28 vaccine vaccine NN cord-005453-4057qib7 3695 29 injection injection NN cord-005453-4057qib7 3695 30 . . . cord-005453-4057qib7 3696 1 Results result NNS cord-005453-4057qib7 3696 2 : : : cord-005453-4057qib7 3697 1 Twenty twenty CD cord-005453-4057qib7 3697 2 - - HYPH cord-005453-4057qib7 3697 3 nine nine CD cord-005453-4057qib7 3697 4 out out IN cord-005453-4057qib7 3697 5 of of IN cord-005453-4057qib7 3697 6 49 49 CD cord-005453-4057qib7 3697 7 patients patient NNS cord-005453-4057qib7 3697 8 were be VBD cord-005453-4057qib7 3697 9 evaluable evaluable JJ cord-005453-4057qib7 3697 10 ( ( -LRB- cord-005453-4057qib7 3697 11 table table NN cord-005453-4057qib7 3697 12 1 1 CD cord-005453-4057qib7 3697 13 ) ) -RRB- cord-005453-4057qib7 3697 14 , , , cord-005453-4057qib7 3697 15 16 16 CD cord-005453-4057qib7 3697 16 without without IN cord-005453-4057qib7 3697 17 GvHD GvHD NNP cord-005453-4057qib7 3697 18 and and CC cord-005453-4057qib7 3697 19 13 13 CD cord-005453-4057qib7 3697 20 with with IN cord-005453-4057qib7 3697 21 chronic chronic JJ cord-005453-4057qib7 3697 22 GvHD GvHD NNP cord-005453-4057qib7 3697 23 ( ( -LRB- cord-005453-4057qib7 3697 24 5 5 CD cord-005453-4057qib7 3697 25 mild mild JJ cord-005453-4057qib7 3697 26 , , , cord-005453-4057qib7 3697 27 4 4 CD cord-005453-4057qib7 3697 28 moderate moderate JJ cord-005453-4057qib7 3697 29 , , , cord-005453-4057qib7 3697 30 4 4 CD cord-005453-4057qib7 3697 31 severe severe NN cord-005453-4057qib7 3697 32 ) ) -RRB- cord-005453-4057qib7 3697 33 . . . cord-005453-4057qib7 3698 1 Median median JJ cord-005453-4057qib7 3698 2 time time NN cord-005453-4057qib7 3698 3 after after IN cord-005453-4057qib7 3698 4 HSCT HSCT NNP cord-005453-4057qib7 3698 5 was be VBD cord-005453-4057qib7 3698 6 34 34 CD cord-005453-4057qib7 3698 7 months month NNS cord-005453-4057qib7 3698 8 ( ( -LRB- cord-005453-4057qib7 3698 9 16 16 CD cord-005453-4057qib7 3698 10 - - SYM cord-005453-4057qib7 3698 11 240 240 CD cord-005453-4057qib7 3698 12 ) ) -RRB- cord-005453-4057qib7 3698 13 . . . cord-005453-4057qib7 3699 1 Median median JJ cord-005453-4057qib7 3699 2 number number NN cord-005453-4057qib7 3699 3 of of IN cord-005453-4057qib7 3699 4 vaccines vaccine NNS cord-005453-4057qib7 3699 5 received receive VBN cord-005453-4057qib7 3699 6 was be VBD cord-005453-4057qib7 3699 7 8 8 CD cord-005453-4057qib7 3699 8 ( ( -LRB- cord-005453-4057qib7 3699 9 1 1 CD cord-005453-4057qib7 3699 10 ) ) -RRB- cord-005453-4057qib7 3699 11 ( ( -LRB- cord-005453-4057qib7 3699 12 2 2 LS cord-005453-4057qib7 3699 13 ) ) -RRB- cord-005453-4057qib7 3699 14 ( ( -LRB- cord-005453-4057qib7 3699 15 3 3 LS cord-005453-4057qib7 3699 16 ) ) -RRB- cord-005453-4057qib7 3699 17 ( ( -LRB- cord-005453-4057qib7 3699 18 4 4 LS cord-005453-4057qib7 3699 19 ) ) -RRB- cord-005453-4057qib7 3699 20 ( ( -LRB- cord-005453-4057qib7 3699 21 5 5 LS cord-005453-4057qib7 3699 22 ) ) -RRB- cord-005453-4057qib7 3699 23 ( ( -LRB- cord-005453-4057qib7 3699 24 6 6 LS cord-005453-4057qib7 3699 25 ) ) -RRB- cord-005453-4057qib7 3699 26 ( ( -LRB- cord-005453-4057qib7 3699 27 7 7 LS cord-005453-4057qib7 3699 28 ) ) -RRB- cord-005453-4057qib7 3699 29 ( ( -LRB- cord-005453-4057qib7 3699 30 8) 8) NNP cord-005453-4057qib7 3699 31 ( ( -LRB- cord-005453-4057qib7 3699 32 9 9 CD cord-005453-4057qib7 3699 33 ) ) -RRB- cord-005453-4057qib7 3699 34 ( ( -LRB- cord-005453-4057qib7 3699 35 10 10 CD cord-005453-4057qib7 3699 36 ) ) -RRB- cord-005453-4057qib7 3699 37 ( ( -LRB- cord-005453-4057qib7 3699 38 11 11 CD cord-005453-4057qib7 3699 39 ) ) -RRB- cord-005453-4057qib7 3699 40 ( ( -LRB- cord-005453-4057qib7 3699 41 12 12 CD cord-005453-4057qib7 3699 42 ) ) -RRB- cord-005453-4057qib7 3699 43 ( ( -LRB- cord-005453-4057qib7 3699 44 13 13 CD cord-005453-4057qib7 3699 45 ) ) -RRB- cord-005453-4057qib7 3699 46 ( ( -LRB- cord-005453-4057qib7 3699 47 14 14 CD cord-005453-4057qib7 3699 48 ) ) -RRB- cord-005453-4057qib7 3699 49 . . . cord-005453-4057qib7 3700 1 As as IN cord-005453-4057qib7 3700 2 regards regard VBZ cord-005453-4057qib7 3700 3 patients patient NNS cord-005453-4057qib7 3700 4 without without IN cord-005453-4057qib7 3700 5 chronic chronic JJ cord-005453-4057qib7 3700 6 GvHD gvhd NN cord-005453-4057qib7 3700 7 , , , cord-005453-4057qib7 3700 8 2 2 CD cord-005453-4057qib7 3700 9 out out IN cord-005453-4057qib7 3700 10 of of IN cord-005453-4057qib7 3700 11 16 16 CD cord-005453-4057qib7 3700 12 experienced experienced JJ cord-005453-4057qib7 3700 13 fever fever NN cord-005453-4057qib7 3700 14 after after IN cord-005453-4057qib7 3700 15 vaccine vaccine NN cord-005453-4057qib7 3700 16 injections injection NNS cord-005453-4057qib7 3700 17 ; ; : cord-005453-4057qib7 3700 18 1 1 CD cord-005453-4057qib7 3700 19 out out IN cord-005453-4057qib7 3700 20 of of IN cord-005453-4057qib7 3700 21 16 16 CD cord-005453-4057qib7 3700 22 developed develop VBN cord-005453-4057qib7 3700 23 transient transient JJ cord-005453-4057qib7 3700 24 mild mild JJ cord-005453-4057qib7 3700 25 reduction reduction NN cord-005453-4057qib7 3700 26 of of IN cord-005453-4057qib7 3700 27 platelet platelet NN cord-005453-4057qib7 3700 28 count count NN cord-005453-4057qib7 3700 29 ; ; : cord-005453-4057qib7 3700 30 1 1 CD cord-005453-4057qib7 3700 31 patient patient NN cord-005453-4057qib7 3700 32 reported report VBD cord-005453-4057qib7 3700 33 headache headache NN cord-005453-4057qib7 3700 34 and and CC cord-005453-4057qib7 3700 35 otalgia otalgia NNP cord-005453-4057qib7 3700 36 after after IN cord-005453-4057qib7 3700 37 vaccine vaccine NN cord-005453-4057qib7 3700 38 injection injection NN cord-005453-4057qib7 3700 39 , , , cord-005453-4057qib7 3700 40 while while IN cord-005453-4057qib7 3700 41 another another DT cord-005453-4057qib7 3700 42 one one CD cord-005453-4057qib7 3700 43 transient transient JJ cord-005453-4057qib7 3700 44 joint joint JJ cord-005453-4057qib7 3700 45 pain pain NN cord-005453-4057qib7 3700 46 ; ; : cord-005453-4057qib7 3700 47 1 1 CD cord-005453-4057qib7 3700 48 out out IN cord-005453-4057qib7 3700 49 of of IN cord-005453-4057qib7 3700 50 16 16 CD cord-005453-4057qib7 3700 51 patients patient NNS cord-005453-4057qib7 3700 52 presented present VBD cord-005453-4057qib7 3700 53 signs sign NNS cord-005453-4057qib7 3700 54 of of IN cord-005453-4057qib7 3700 55 mouth mouth NN cord-005453-4057qib7 3700 56 chronic chronic JJ cord-005453-4057qib7 3700 57 GvHD GvHD NNP cord-005453-4057qib7 3700 58 ( ( -LRB- cord-005453-4057qib7 3700 59 score score NN cord-005453-4057qib7 3700 60 1 1 CD cord-005453-4057qib7 3700 61 NIH NIH NNP cord-005453-4057qib7 3700 62 ) ) -RRB- cord-005453-4057qib7 3700 63 and and CC cord-005453-4057qib7 3700 64 transaminase transaminase FW cord-005453-4057qib7 3700 65 increase increase NN cord-005453-4057qib7 3700 66 ( ( -LRB- cord-005453-4057qib7 3700 67 grade grade NN cord-005453-4057qib7 3700 68 1 1 CD cord-005453-4057qib7 3700 69 according accord VBG cord-005453-4057qib7 3700 70 to to IN cord-005453-4057qib7 3700 71 World World NNP cord-005453-4057qib7 3700 72 Health Health NNP cord-005453-4057qib7 3700 73 Organization Organization NNP cord-005453-4057qib7 3700 74 Toxicity toxicity NN cord-005453-4057qib7 3700 75 Scale Scale NNP cord-005453-4057qib7 3700 76 ) ) -RRB- cord-005453-4057qib7 3700 77 3 3 CD cord-005453-4057qib7 3700 78 months month NNS cord-005453-4057qib7 3700 79 after after IN cord-005453-4057qib7 3700 80 the the DT cord-005453-4057qib7 3700 81 first first JJ cord-005453-4057qib7 3700 82 vaccine vaccine NN cord-005453-4057qib7 3700 83 dose dose NN cord-005453-4057qib7 3700 84 , , , cord-005453-4057qib7 3700 85 so so IN cord-005453-4057qib7 3700 86 that that IN cord-005453-4057qib7 3700 87 cyclosporine cyclosporine JJ cord-005453-4057qib7 3700 88 dose dose NN cord-005453-4057qib7 3700 89 had have VBD cord-005453-4057qib7 3700 90 to to TO cord-005453-4057qib7 3700 91 be be VB cord-005453-4057qib7 3700 92 augmented augment VBN cord-005453-4057qib7 3700 93 . . . cord-005453-4057qib7 3701 1 As as IN cord-005453-4057qib7 3701 2 regards regard VBZ cord-005453-4057qib7 3701 3 patients patient NNS cord-005453-4057qib7 3701 4 with with IN cord-005453-4057qib7 3701 5 chronic chronic JJ cord-005453-4057qib7 3701 6 GvHD GvHD NNP cord-005453-4057qib7 3701 7 , , , cord-005453-4057qib7 3701 8 4 4 CD cord-005453-4057qib7 3701 9 out out IN cord-005453-4057qib7 3701 10 of of IN cord-005453-4057qib7 3701 11 13 13 CD cord-005453-4057qib7 3701 12 experienced experienced JJ cord-005453-4057qib7 3701 13 fever fever NN cord-005453-4057qib7 3701 14 after after IN cord-005453-4057qib7 3701 15 vaccine vaccine NN cord-005453-4057qib7 3701 16 injections injection NNS cord-005453-4057qib7 3701 17 ; ; : cord-005453-4057qib7 3701 18 2 2 CD cord-005453-4057qib7 3701 19 patients patient NNS cord-005453-4057qib7 3701 20 with with IN cord-005453-4057qib7 3701 21 mild mild JJ cord-005453-4057qib7 3701 22 chronic chronic JJ cord-005453-4057qib7 3701 23 GvHD gvhd NN cord-005453-4057qib7 3701 24 of of IN cord-005453-4057qib7 3701 25 the the DT cord-005453-4057qib7 3701 26 mouth mouth NN cord-005453-4057qib7 3701 27 presented present VBD cord-005453-4057qib7 3701 28 hepatic hepatic JJ cord-005453-4057qib7 3701 29 flare flare NN cord-005453-4057qib7 3701 30 two two CD cord-005453-4057qib7 3701 31 and and CC cord-005453-4057qib7 3701 32 three three CD cord-005453-4057qib7 3701 33 months month NNS cord-005453-4057qib7 3701 34 after after IN cord-005453-4057qib7 3701 35 the the DT cord-005453-4057qib7 3701 36 first first JJ cord-005453-4057qib7 3701 37 vaccine vaccine NN cord-005453-4057qib7 3701 38 dose dose NN cord-005453-4057qib7 3701 39 , , , cord-005453-4057qib7 3701 40 respectively respectively RB cord-005453-4057qib7 3701 41 . . . cord-005453-4057qib7 3702 1 In in IN cord-005453-4057qib7 3702 2 both both DT cord-005453-4057qib7 3702 3 cases case NNS cord-005453-4057qib7 3702 4 a a DT cord-005453-4057qib7 3702 5 new new JJ cord-005453-4057qib7 3702 6 increase increase NN cord-005453-4057qib7 3702 7 of of IN cord-005453-4057qib7 3702 8 cyclosporin cyclosporin NN cord-005453-4057qib7 3702 9 and and CC cord-005453-4057qib7 3702 10 methylprednisolone methylprednisolone JJ cord-005453-4057qib7 3702 11 doses dose NNS cord-005453-4057qib7 3702 12 determined determine VBD cord-005453-4057qib7 3702 13 progressive progressive JJ cord-005453-4057qib7 3702 14 normalization normalization NN cord-005453-4057qib7 3702 15 of of IN cord-005453-4057qib7 3702 16 liver liver NN cord-005453-4057qib7 3702 17 enzymes enzyme NNS cord-005453-4057qib7 3702 18 . . . cord-005453-4057qib7 3703 1 Conclusions conclusion NNS cord-005453-4057qib7 3703 2 : : : cord-005453-4057qib7 3704 1 These these DT cord-005453-4057qib7 3704 2 data datum NNS cord-005453-4057qib7 3704 3 show show VBP cord-005453-4057qib7 3704 4 that that IN cord-005453-4057qib7 3704 5 vaccines vaccine NNS cord-005453-4057qib7 3704 6 were be VBD cord-005453-4057qib7 3704 7 globally globally RB cord-005453-4057qib7 3704 8 well well RB cord-005453-4057qib7 3704 9 tolerated tolerate VBN cord-005453-4057qib7 3704 10 in in IN cord-005453-4057qib7 3704 11 HSCT HSCT NNP cord-005453-4057qib7 3704 12 recipients recipient NNS cord-005453-4057qib7 3704 13 , , , cord-005453-4057qib7 3704 14 even even RB cord-005453-4057qib7 3704 15 when when WRB cord-005453-4057qib7 3704 16 they -PRON- PRP cord-005453-4057qib7 3704 17 suffered suffer VBD cord-005453-4057qib7 3704 18 from from IN cord-005453-4057qib7 3704 19 chronic chronic JJ cord-005453-4057qib7 3704 20 GvHD GvHD NNP cord-005453-4057qib7 3704 21 . . . cord-005453-4057qib7 3705 1 However however RB cord-005453-4057qib7 3705 2 , , , cord-005453-4057qib7 3705 3 close close JJ cord-005453-4057qib7 3705 4 monitoring monitoring NN cord-005453-4057qib7 3705 5 is be VBZ cord-005453-4057qib7 3705 6 warranted warrant VBN cord-005453-4057qib7 3705 7 in in IN cord-005453-4057qib7 3705 8 order order NN cord-005453-4057qib7 3705 9 to to TO cord-005453-4057qib7 3705 10 better better RB cord-005453-4057qib7 3705 11 evaluate evaluate VB cord-005453-4057qib7 3705 12 possible possible JJ cord-005453-4057qib7 3705 13 vaccine vaccine NN cord-005453-4057qib7 3705 14 side side NN cord-005453-4057qib7 3705 15 effects effect NNS cord-005453-4057qib7 3705 16 in in IN cord-005453-4057qib7 3705 17 this this DT cord-005453-4057qib7 3705 18 setting setting NN cord-005453-4057qib7 3705 19 of of IN cord-005453-4057qib7 3705 20 patients patient NNS cord-005453-4057qib7 3705 21 . . . cord-005453-4057qib7 3706 1 Background background NN cord-005453-4057qib7 3706 2 : : : cord-005453-4057qib7 3707 1 Allogeneic allogeneic IN cord-005453-4057qib7 3707 2 HSCT HSCT NNP cord-005453-4057qib7 3707 3 improves improve VBZ cord-005453-4057qib7 3707 4 survival survival NN cord-005453-4057qib7 3707 5 for for IN cord-005453-4057qib7 3707 6 AML AML NNP cord-005453-4057qib7 3707 7 patients patient NNS cord-005453-4057qib7 3707 8 over over IN cord-005453-4057qib7 3707 9 the the DT cord-005453-4057qib7 3707 10 age age NN cord-005453-4057qib7 3707 11 of of IN cord-005453-4057qib7 3707 12 60 60 CD cord-005453-4057qib7 3707 13 years year NNS cord-005453-4057qib7 3707 14 of of IN cord-005453-4057qib7 3707 15 age age NN cord-005453-4057qib7 3707 16 when when WRB cord-005453-4057qib7 3707 17 compared compare VBN cord-005453-4057qib7 3707 18 to to IN cord-005453-4057qib7 3707 19 chemotherapy chemotherapy NN cord-005453-4057qib7 3707 20 alone alone RB cord-005453-4057qib7 3707 21 . . . cord-005453-4057qib7 3708 1 The the DT cord-005453-4057qib7 3708 2 haematopoietic haematopoietic JJ cord-005453-4057qib7 3708 3 stem stem NN cord-005453-4057qib7 3708 4 cell cell NN cord-005453-4057qib7 3708 5 transplantation transplantation NN cord-005453-4057qib7 3708 6 comorbidity comorbidity NN cord-005453-4057qib7 3708 7 index index NN cord-005453-4057qib7 3708 8 ( ( -LRB- cord-005453-4057qib7 3708 9 HCT HCT NNP cord-005453-4057qib7 3708 10 - - HYPH cord-005453-4057qib7 3708 11 CI CI NNP cord-005453-4057qib7 3708 12 ) ) -RRB- cord-005453-4057qib7 3708 13 and and CC cord-005453-4057qib7 3708 14 EBMT EBMT NNP cord-005453-4057qib7 3708 15 score score NN cord-005453-4057qib7 3708 16 predict predict VB cord-005453-4057qib7 3708 17 for for IN cord-005453-4057qib7 3708 18 non non JJ cord-005453-4057qib7 3708 19 - - JJ cord-005453-4057qib7 3708 20 relapse relapse JJ cord-005453-4057qib7 3708 21 mortality mortality NN cord-005453-4057qib7 3708 22 and and CC cord-005453-4057qib7 3708 23 overall overall JJ cord-005453-4057qib7 3708 24 survival survival NN cord-005453-4057qib7 3708 25 , , , cord-005453-4057qib7 3708 26 yet yet CC cord-005453-4057qib7 3708 27 little little JJ cord-005453-4057qib7 3708 28 is be VBZ cord-005453-4057qib7 3708 29 known know VBN cord-005453-4057qib7 3708 30 about about IN cord-005453-4057qib7 3708 31 whether whether IN cord-005453-4057qib7 3708 32 QoL QoL NNP cord-005453-4057qib7 3708 33 is be VBZ cord-005453-4057qib7 3708 34 preserved preserve VBN cord-005453-4057qib7 3708 35 in in IN cord-005453-4057qib7 3708 36 this this DT cord-005453-4057qib7 3708 37 patient patient NN cord-005453-4057qib7 3708 38 group group NN cord-005453-4057qib7 3708 39 and and CC cord-005453-4057qib7 3708 40 whether whether IN cord-005453-4057qib7 3708 41 HCT HCT NNP cord-005453-4057qib7 3708 42 - - HYPH cord-005453-4057qib7 3708 43 CI CI NNP cord-005453-4057qib7 3708 44 and and CC cord-005453-4057qib7 3708 45 other other JJ cord-005453-4057qib7 3708 46 performance performance NN cord-005453-4057qib7 3708 47 scores score NNS cord-005453-4057qib7 3708 48 pre pre JJ cord-005453-4057qib7 3708 49 - - NNP cord-005453-4057qib7 3708 50 BMT BMT NNP cord-005453-4057qib7 3708 51 correlate correlate VB cord-005453-4057qib7 3708 52 with with IN cord-005453-4057qib7 3708 53 QoL qol FW cord-005453-4057qib7 3708 54 post post AFX cord-005453-4057qib7 3708 55 allo allo NN cord-005453-4057qib7 3708 56 - - HYPH cord-005453-4057qib7 3708 57 HSCT HSCT NNP cord-005453-4057qib7 3708 58 . . . cord-005453-4057qib7 3709 1 Methods method NNS cord-005453-4057qib7 3709 2 : : : cord-005453-4057qib7 3709 3 We -PRON- PRP cord-005453-4057qib7 3709 4 conducted conduct VBD cord-005453-4057qib7 3709 5 a a DT cord-005453-4057qib7 3709 6 retrospective retrospective JJ cord-005453-4057qib7 3709 7 analysis analysis NN cord-005453-4057qib7 3709 8 of of IN cord-005453-4057qib7 3709 9 patients patient NNS cord-005453-4057qib7 3709 10 60 60 CD cord-005453-4057qib7 3709 11 years year NNS cord-005453-4057qib7 3709 12 and and CC cord-005453-4057qib7 3709 13 older old JJR cord-005453-4057qib7 3709 14 who who WP cord-005453-4057qib7 3709 15 underwent undergo VBD cord-005453-4057qib7 3709 16 RIC RIC NNP cord-005453-4057qib7 3709 17 allo allo NNP cord-005453-4057qib7 3709 18 - - HYPH cord-005453-4057qib7 3709 19 HSCT HSCT NNP cord-005453-4057qib7 3709 20 at at IN cord-005453-4057qib7 3709 21 the the DT cord-005453-4057qib7 3709 22 University University NNP cord-005453-4057qib7 3709 23 Hospital Hospital NNP cord-005453-4057qib7 3709 24 of of IN cord-005453-4057qib7 3709 25 Wales Wales NNP cord-005453-4057qib7 3709 26 , , , cord-005453-4057qib7 3709 27 Cardiff Cardiff NNP cord-005453-4057qib7 3709 28 between between IN cord-005453-4057qib7 3709 29 September September NNP cord-005453-4057qib7 3709 30 2011 2011 CD cord-005453-4057qib7 3709 31 and and CC cord-005453-4057qib7 3709 32 December December NNP cord-005453-4057qib7 3709 33 2017 2017 CD cord-005453-4057qib7 3710 1 ( ( -LRB- cord-005453-4057qib7 3710 2 n=41 n=41 RB cord-005453-4057qib7 3710 3 ) ) -RRB- cord-005453-4057qib7 3710 4 . . . cord-005453-4057qib7 3711 1 HCT HCT NNP cord-005453-4057qib7 3711 2 - - HYPH cord-005453-4057qib7 3711 3 CI CI NNP cord-005453-4057qib7 3711 4 , , , cord-005453-4057qib7 3711 5 Karnofsky Karnofsky NNP cord-005453-4057qib7 3711 6 Performance Performance NNP cord-005453-4057qib7 3711 7 Score Score NNP cord-005453-4057qib7 3711 8 ( ( -LRB- cord-005453-4057qib7 3711 9 KPS KPS NNP cord-005453-4057qib7 3711 10 ) ) -RRB- cord-005453-4057qib7 3711 11 and and CC cord-005453-4057qib7 3711 12 EBMT EBMT NNP cord-005453-4057qib7 3711 13 scores score NNS cord-005453-4057qib7 3711 14 were be VBD cord-005453-4057qib7 3711 15 calculated calculate VBN cord-005453-4057qib7 3711 16 prior prior RB cord-005453-4057qib7 3711 17 to to IN cord-005453-4057qib7 3711 18 transplant transplant NN cord-005453-4057qib7 3711 19 and and CC cord-005453-4057qib7 3711 20 QoL qol NN cord-005453-4057qib7 3711 21 measured measure VBN cord-005453-4057qib7 3711 22 using use VBG cord-005453-4057qib7 3711 23 the the DT cord-005453-4057qib7 3711 24 FACT FACT NNP cord-005453-4057qib7 3711 25 BMT BMT NNP cord-005453-4057qib7 3711 26 ( ( -LRB- cord-005453-4057qib7 3711 27 version version NN cord-005453-4057qib7 3711 28 4 4 CD cord-005453-4057qib7 3711 29 ) ) -RRB- cord-005453-4057qib7 3711 30 questionnaire questionnaire NN cord-005453-4057qib7 3711 31 , , , cord-005453-4057qib7 3711 32 which which WDT cord-005453-4057qib7 3711 33 was be VBD cord-005453-4057qib7 3711 34 completed complete VBN cord-005453-4057qib7 3711 35 at at IN cord-005453-4057qib7 3711 36 3 3 CD cord-005453-4057qib7 3711 37 , , , cord-005453-4057qib7 3711 38 6 6 CD cord-005453-4057qib7 3711 39 and and CC cord-005453-4057qib7 3711 40 12 12 CD cord-005453-4057qib7 3711 41 months month NNS cord-005453-4057qib7 3711 42 post post NN cord-005453-4057qib7 3711 43 transplant transplant NN cord-005453-4057qib7 3711 44 . . . cord-005453-4057qib7 3712 1 Patients patient NNS cord-005453-4057qib7 3712 2 were be VBD cord-005453-4057qib7 3712 3 grouped group VBN cord-005453-4057qib7 3712 4 at at IN cord-005453-4057qib7 3712 5 the the DT cord-005453-4057qib7 3712 6 3- 3- NNP cord-005453-4057qib7 3712 7 , , , cord-005453-4057qib7 3712 8 6-and 6-and CD cord-005453-4057qib7 3712 9 12-month 12-month JJ cord-005453-4057qib7 3712 10 time time NN cord-005453-4057qib7 3712 11 points point NNS cord-005453-4057qib7 3712 12 for for IN cord-005453-4057qib7 3712 13 each each DT cord-005453-4057qib7 3712 14 of of IN cord-005453-4057qib7 3712 15 the the DT cord-005453-4057qib7 3712 16 different different JJ cord-005453-4057qib7 3712 17 performance performance NN cord-005453-4057qib7 3712 18 indices index NNS cord-005453-4057qib7 3712 19 , , , cord-005453-4057qib7 3712 20 allowing allow VBG cord-005453-4057qib7 3712 21 group group NN cord-005453-4057qib7 3712 22 comparison comparison NN cord-005453-4057qib7 3712 23 against against IN cord-005453-4057qib7 3712 24 compound compound NN cord-005453-4057qib7 3712 25 sub sub NN cord-005453-4057qib7 3712 26 scores score NNS cord-005453-4057qib7 3712 27 using use VBG cord-005453-4057qib7 3712 28 the the DT cord-005453-4057qib7 3712 29 Mann Mann NNP cord-005453-4057qib7 3712 30 - - HYPH cord-005453-4057qib7 3712 31 Whitney Whitney NNP cord-005453-4057qib7 3712 32 U U NNP cord-005453-4057qib7 3712 33 test test NN cord-005453-4057qib7 3712 34 . . . cord-005453-4057qib7 3713 1 Results result NNS cord-005453-4057qib7 3713 2 : : : cord-005453-4057qib7 3713 3 41 41 CD cord-005453-4057qib7 3713 4 patients patient NNS cord-005453-4057qib7 3713 5 were be VBD cord-005453-4057qib7 3713 6 included include VBN cord-005453-4057qib7 3713 7 in in IN cord-005453-4057qib7 3713 8 this this DT cord-005453-4057qib7 3713 9 study study NN cord-005453-4057qib7 3713 10 , , , cord-005453-4057qib7 3713 11 with with IN cord-005453-4057qib7 3713 12 median median JJ cord-005453-4057qib7 3713 13 age age NN cord-005453-4057qib7 3713 14 65 65 CD cord-005453-4057qib7 3713 15 years year NNS cord-005453-4057qib7 3714 1 ( ( -LRB- cord-005453-4057qib7 3714 2 range range NNP cord-005453-4057qib7 3714 3 60 60 CD cord-005453-4057qib7 3714 4 - - SYM cord-005453-4057qib7 3714 5 74 74 CD cord-005453-4057qib7 3714 6 ) ) -RRB- cord-005453-4057qib7 3714 7 . . . cord-005453-4057qib7 3715 1 Patient patient JJ cord-005453-4057qib7 3715 2 characteristics characteristic NNS cord-005453-4057qib7 3715 3 , , , cord-005453-4057qib7 3715 4 including include VBG cord-005453-4057qib7 3715 5 conditioning conditioning NN cord-005453-4057qib7 3715 6 , , , cord-005453-4057qib7 3715 7 donor donor NN cord-005453-4057qib7 3715 8 type type NN cord-005453-4057qib7 3715 9 , , , cord-005453-4057qib7 3715 10 pre pre JJ cord-005453-4057qib7 3715 11 - - JJ cord-005453-4057qib7 3715 12 transplant transplant JJ cord-005453-4057qib7 3715 13 HCT HCT NNP cord-005453-4057qib7 3715 14 - - HYPH cord-005453-4057qib7 3715 15 CI CI NNP cord-005453-4057qib7 3715 16 and and CC cord-005453-4057qib7 3715 17 KPS KPS NNP cord-005453-4057qib7 3715 18 scores score NNS cord-005453-4057qib7 3715 19 are be VBP cord-005453-4057qib7 3715 20 summarised summarise VBN cord-005453-4057qib7 3715 21 in in IN cord-005453-4057qib7 3715 22 table table NN cord-005453-4057qib7 3715 23 1 1 CD cord-005453-4057qib7 3715 24 . . . cord-005453-4057qib7 3716 1 The the DT cord-005453-4057qib7 3716 2 2 2 CD cord-005453-4057qib7 3716 3 year year NN cord-005453-4057qib7 3716 4 and and CC cord-005453-4057qib7 3716 5 5 5 CD cord-005453-4057qib7 3716 6 year year NN cord-005453-4057qib7 3716 7 overall overall JJ cord-005453-4057qib7 3716 8 survival survival NN cord-005453-4057qib7 3716 9 ( ( -LRB- cord-005453-4057qib7 3716 10 OS OS NNP cord-005453-4057qib7 3716 11 ) ) -RRB- cord-005453-4057qib7 3716 12 for for IN cord-005453-4057qib7 3716 13 the the DT cord-005453-4057qib7 3716 14 patient patient JJ cord-005453-4057qib7 3716 15 cohort cohort NN cord-005453-4057qib7 3716 16 was be VBD cord-005453-4057qib7 3716 17 65.4 65.4 CD cord-005453-4057qib7 3716 18 % % NN cord-005453-4057qib7 3716 19 and and CC cord-005453-4057qib7 3716 20 48.7 48.7 CD cord-005453-4057qib7 3716 21 % % NN cord-005453-4057qib7 3716 22 respectively respectively RB cord-005453-4057qib7 3716 23 . . . cord-005453-4057qib7 3717 1 HCT HCT NNP cord-005453-4057qib7 3717 2 - - HYPH cord-005453-4057qib7 3717 3 CI CI NNP cord-005453-4057qib7 3717 4 of of IN cord-005453-4057qib7 3717 5 ≥3 ≥3 NNP cord-005453-4057qib7 3717 6 vs vs IN cord-005453-4057qib7 3717 7 0 0 CD cord-005453-4057qib7 3717 8 was be VBD cord-005453-4057qib7 3717 9 significantly significantly RB cord-005453-4057qib7 3717 10 associated associate VBN cord-005453-4057qib7 3717 11 with with IN cord-005453-4057qib7 3717 12 poorer poor JJR cord-005453-4057qib7 3717 13 BMT BMT NNP cord-005453-4057qib7 3717 14 - - HYPH cord-005453-4057qib7 3717 15 related relate VBN cord-005453-4057qib7 3717 16 QoL qol NN cord-005453-4057qib7 3717 17 domains domain NNS cord-005453-4057qib7 3717 18 at at IN cord-005453-4057qib7 3717 19 3 3 CD cord-005453-4057qib7 3717 20 months month NNS cord-005453-4057qib7 3717 21 ( ( -LRB- cord-005453-4057qib7 3717 22 p=0.035 p=0.035 NNP cord-005453-4057qib7 3717 23 ) ) -RRB- cord-005453-4057qib7 3717 24 and and CC cord-005453-4057qib7 3717 25 general general JJ cord-005453-4057qib7 3717 26 QoL qol NN cord-005453-4057qib7 3717 27 domains domain NNS cord-005453-4057qib7 3717 28 at at IN cord-005453-4057qib7 3717 29 6 6 CD cord-005453-4057qib7 3717 30 months month NNS cord-005453-4057qib7 3717 31 ( ( -LRB- cord-005453-4057qib7 3717 32 p=0.025 p=0.025 NNP cord-005453-4057qib7 3717 33 ) ) -RRB- cord-005453-4057qib7 3717 34 post post JJ cord-005453-4057qib7 3717 35 - - NN cord-005453-4057qib7 3717 36 transplant transplant NN cord-005453-4057qib7 3717 37 . . . cord-005453-4057qib7 3718 1 While while IN cord-005453-4057qib7 3718 2 EBMT EBMT NNP cord-005453-4057qib7 3718 3 score score NN cord-005453-4057qib7 3718 4 showed show VBD cord-005453-4057qib7 3718 5 no no DT cord-005453-4057qib7 3718 6 correlation correlation NN cord-005453-4057qib7 3718 7 with with IN cord-005453-4057qib7 3718 8 QoL qol NN cord-005453-4057qib7 3718 9 parameters parameter NNS cord-005453-4057qib7 3718 10 , , , cord-005453-4057qib7 3718 11 patients patient NNS cord-005453-4057qib7 3718 12 with with IN cord-005453-4057qib7 3718 13 KPS KPS NNP cord-005453-4057qib7 3718 14 of of IN cord-005453-4057qib7 3718 15 100 100 CD cord-005453-4057qib7 3718 16 vs vs IN cord-005453-4057qib7 3718 17 ≤90 ≤90 NNP cord-005453-4057qib7 3718 18 showed show VBD cord-005453-4057qib7 3718 19 significant significant JJ cord-005453-4057qib7 3718 20 differences difference NNS cord-005453-4057qib7 3718 21 in in IN cord-005453-4057qib7 3718 22 both both DT cord-005453-4057qib7 3718 23 general general JJ cord-005453-4057qib7 3718 24 ( ( -LRB- cord-005453-4057qib7 3718 25 p=0.01 p=0.01 NNP cord-005453-4057qib7 3718 26 ) ) -RRB- cord-005453-4057qib7 3718 27 and and CC cord-005453-4057qib7 3718 28 BMT BMT NNP cord-005453-4057qib7 3718 29 - - HYPH cord-005453-4057qib7 3718 30 related relate VBN cord-005453-4057qib7 3718 31 QoL qol NN cord-005453-4057qib7 3718 32 ( ( -LRB- cord-005453-4057qib7 3718 33 p=0.04 p=0.04 NN cord-005453-4057qib7 3718 34 ) ) -RRB- cord-005453-4057qib7 3718 35 at at IN cord-005453-4057qib7 3718 36 3 3 CD cord-005453-4057qib7 3718 37 months month NNS cord-005453-4057qib7 3718 38 and and CC cord-005453-4057qib7 3718 39 in in IN cord-005453-4057qib7 3718 40 all all DT cord-005453-4057qib7 3718 41 QoL qol NN cord-005453-4057qib7 3718 42 domains domain NNS cord-005453-4057qib7 3718 43 at at IN cord-005453-4057qib7 3718 44 6 6 CD cord-005453-4057qib7 3718 45 months month NNS cord-005453-4057qib7 3718 46 ( ( -LRB- cord-005453-4057qib7 3718 47 symptomrelated symptomrelate VBN cord-005453-4057qib7 3718 48 QoL QoL NNP cord-005453-4057qib7 3718 49 p=0.05 p=0.05 NNP cord-005453-4057qib7 3718 50 , , , cord-005453-4057qib7 3718 51 general general JJ cord-005453-4057qib7 3718 52 QoL qol NN cord-005453-4057qib7 3718 53 p=0.01 p=0.01 NNP cord-005453-4057qib7 3718 54 , , , cord-005453-4057qib7 3718 55 BMT BMT NNP cord-005453-4057qib7 3718 56 - - HYPH cord-005453-4057qib7 3718 57 related relate VBN cord-005453-4057qib7 3718 58 QoL qol NN cord-005453-4057qib7 3718 59 p=0.01 p=0.01 NNP cord-005453-4057qib7 3718 60 ) ) -RRB- cord-005453-4057qib7 3718 61 . . . cord-005453-4057qib7 3719 1 Importantly importantly RB cord-005453-4057qib7 3719 2 neither neither CC cord-005453-4057qib7 3719 3 the the DT cord-005453-4057qib7 3719 4 HCT HCT NNP cord-005453-4057qib7 3719 5 - - HYPH cord-005453-4057qib7 3719 6 CI CI NNP cord-005453-4057qib7 3719 7 nor nor CC cord-005453-4057qib7 3719 8 the the DT cord-005453-4057qib7 3719 9 KPS KPS NNP cord-005453-4057qib7 3719 10 pre pre JJ cord-005453-4057qib7 3719 11 - - JJ cord-005453-4057qib7 3719 12 transplant transplant NN cord-005453-4057qib7 3719 13 predicted predict VBN cord-005453-4057qib7 3719 14 for for IN cord-005453-4057qib7 3719 15 QoL QoL NNP cord-005453-4057qib7 3719 16 at at IN cord-005453-4057qib7 3719 17 12 12 CD cord-005453-4057qib7 3719 18 months month NNS cord-005453-4057qib7 3719 19 post post NN cord-005453-4057qib7 3719 20 transplant transplant NN cord-005453-4057qib7 3719 21 . . . cord-005453-4057qib7 3720 1 Conclusions conclusion NNS cord-005453-4057qib7 3720 2 : : : cord-005453-4057qib7 3721 1 Patient patient JJ cord-005453-4057qib7 3721 2 selection selection NN cord-005453-4057qib7 3721 3 is be VBZ cord-005453-4057qib7 3721 4 key key JJ cord-005453-4057qib7 3721 5 to to IN cord-005453-4057qib7 3721 6 ensuring ensure VBG cord-005453-4057qib7 3721 7 maximum maximum JJ cord-005453-4057qib7 3721 8 benefit benefit NN cord-005453-4057qib7 3721 9 from from IN cord-005453-4057qib7 3721 10 allo allo NN cord-005453-4057qib7 3721 11 - - HYPH cord-005453-4057qib7 3721 12 HSCT HSCT NNP cord-005453-4057qib7 3721 13 both both CC cord-005453-4057qib7 3721 14 in in IN cord-005453-4057qib7 3721 15 terms term NNS cord-005453-4057qib7 3721 16 of of IN cord-005453-4057qib7 3721 17 overall overall JJ cord-005453-4057qib7 3721 18 survival survival NN cord-005453-4057qib7 3721 19 but but CC cord-005453-4057qib7 3721 20 also also RB cord-005453-4057qib7 3721 21 with with IN cord-005453-4057qib7 3721 22 regards regard NNS cord-005453-4057qib7 3721 23 to to IN cord-005453-4057qib7 3721 24 QoL qol NN cord-005453-4057qib7 3721 25 and and CC cord-005453-4057qib7 3721 26 survivorship survivorship NN cord-005453-4057qib7 3721 27 . . . cord-005453-4057qib7 3722 1 We -PRON- PRP cord-005453-4057qib7 3722 2 note note VBP cord-005453-4057qib7 3722 3 that that IN cord-005453-4057qib7 3722 4 while while IN cord-005453-4057qib7 3722 5 patients patient NNS cord-005453-4057qib7 3722 6 with with IN cord-005453-4057qib7 3722 7 HCT HCT NNP cord-005453-4057qib7 3722 8 - - HYPH cord-005453-4057qib7 3722 9 CI CI NNP cord-005453-4057qib7 3722 10 ³3 ³3 NN cord-005453-4057qib7 3722 11 or or CC cord-005453-4057qib7 3722 12 KPS KPS NNP cord-005453-4057qib7 3722 13 ≤90 ≤90 NNP cord-005453-4057qib7 3722 14 had have VBD cord-005453-4057qib7 3722 15 significantly significantly RB cord-005453-4057qib7 3722 16 poorer poor JJR cord-005453-4057qib7 3722 17 QoL qol NN cord-005453-4057qib7 3722 18 at at IN cord-005453-4057qib7 3722 19 6 6 CD cord-005453-4057qib7 3722 20 months month NNS cord-005453-4057qib7 3722 21 post post NN cord-005453-4057qib7 3722 22 allo allo NN cord-005453-4057qib7 3722 23 - - HYPH cord-005453-4057qib7 3722 24 HSCT HSCT NNP cord-005453-4057qib7 3722 25 , , , cord-005453-4057qib7 3723 1 QoL QoL NNP cord-005453-4057qib7 3723 2 was be VBD cord-005453-4057qib7 3723 3 recovered recover VBN cord-005453-4057qib7 3723 4 by by IN cord-005453-4057qib7 3723 5 12 12 CD cord-005453-4057qib7 3723 6 months month NNS cord-005453-4057qib7 3723 7 post post NN cord-005453-4057qib7 3723 8 transplant transplant NN cord-005453-4057qib7 3723 9 , , , cord-005453-4057qib7 3723 10 with with IN cord-005453-4057qib7 3723 11 this this DT cord-005453-4057qib7 3723 12 significant significant JJ cord-005453-4057qib7 3723 13 difference difference NN cord-005453-4057qib7 3723 14 no no RB cord-005453-4057qib7 3723 15 longer long RBR cord-005453-4057qib7 3723 16 seen see VBN cord-005453-4057qib7 3723 17 . . . cord-005453-4057qib7 3724 1 Our -PRON- PRP$ cord-005453-4057qib7 3724 2 data data NN cord-005453-4057qib7 3724 3 shows show VBZ cord-005453-4057qib7 3724 4 that that IN cord-005453-4057qib7 3724 5 in in IN cord-005453-4057qib7 3724 6 selected select VBN cord-005453-4057qib7 3724 7 AML AML NNP cord-005453-4057qib7 3724 8 patients patient NNS cord-005453-4057qib7 3724 9 over over IN cord-005453-4057qib7 3724 10 the the DT cord-005453-4057qib7 3724 11 age age NN cord-005453-4057qib7 3724 12 of of IN cord-005453-4057qib7 3724 13 60 60 CD cord-005453-4057qib7 3724 14 years year NNS cord-005453-4057qib7 3724 15 with with IN cord-005453-4057qib7 3724 16 good good JJ cord-005453-4057qib7 3724 17 performance performance NN cord-005453-4057qib7 3724 18 status status NN cord-005453-4057qib7 3724 19 and and CC cord-005453-4057qib7 3724 20 low low JJ cord-005453-4057qib7 3724 21 comorbidity comorbidity NN cord-005453-4057qib7 3724 22 index index NN cord-005453-4057qib7 3724 23 , , , cord-005453-4057qib7 3724 24 a a DT cord-005453-4057qib7 3724 25 favourable favourable JJ cord-005453-4057qib7 3724 26 outcome outcome NN cord-005453-4057qib7 3724 27 can can MD cord-005453-4057qib7 3724 28 be be VB cord-005453-4057qib7 3724 29 achieved achieve VBN cord-005453-4057qib7 3724 30 with with IN cord-005453-4057qib7 3724 31 good good JJ cord-005453-4057qib7 3724 32 QoL qol NN cord-005453-4057qib7 3724 33 maintained maintain VBN cord-005453-4057qib7 3724 34 throughout throughout IN cord-005453-4057qib7 3724 35 the the DT cord-005453-4057qib7 3724 36 post post NN cord-005453-4057qib7 3724 37 transplant transplant NN cord-005453-4057qib7 3724 38 period period NN cord-005453-4057qib7 3724 39 . . . cord-005453-4057qib7 3725 1 Background background NN cord-005453-4057qib7 3725 2 : : : cord-005453-4057qib7 3726 1 Advances advance NNS cord-005453-4057qib7 3726 2 in in IN cord-005453-4057qib7 3726 3 alloSCT alloSCT NNP cord-005453-4057qib7 3726 4 technology technology NN cord-005453-4057qib7 3726 5 , , , cord-005453-4057qib7 3726 6 supportive supportive JJ cord-005453-4057qib7 3726 7 care care NN cord-005453-4057qib7 3726 8 , , , cord-005453-4057qib7 3726 9 and and CC cord-005453-4057qib7 3726 10 use use NN cord-005453-4057qib7 3726 11 of of IN cord-005453-4057qib7 3726 12 reduced reduced JJ cord-005453-4057qib7 3726 13 intensity intensity NN cord-005453-4057qib7 3726 14 conditioning conditioning NN cord-005453-4057qib7 3726 15 regimens regimen NNS cord-005453-4057qib7 3726 16 for for IN cord-005453-4057qib7 3726 17 older old JJR cord-005453-4057qib7 3726 18 patients patient NNS cord-005453-4057qib7 3726 19 have have VBP cord-005453-4057qib7 3726 20 led lead VBN cord-005453-4057qib7 3726 21 to to IN cord-005453-4057qib7 3726 22 significant significant JJ cord-005453-4057qib7 3726 23 improvements improvement NNS cord-005453-4057qib7 3726 24 in in IN cord-005453-4057qib7 3726 25 longterm longterm JJ cord-005453-4057qib7 3726 26 survival survival NN cord-005453-4057qib7 3726 27 after after IN cord-005453-4057qib7 3726 28 transplant transplant NN cord-005453-4057qib7 3726 29 . . . cord-005453-4057qib7 3727 1 The the DT cord-005453-4057qib7 3727 2 survivors survivor NNS cord-005453-4057qib7 3727 3 have have VBP cord-005453-4057qib7 3727 4 an an DT cord-005453-4057qib7 3727 5 elevated elevated JJ cord-005453-4057qib7 3727 6 probability probability NN cord-005453-4057qib7 3727 7 of of IN cord-005453-4057qib7 3727 8 late late JJ cord-005453-4057qib7 3727 9 morbidity morbidity NN cord-005453-4057qib7 3727 10 and and CC cord-005453-4057qib7 3727 11 mortality mortality NN cord-005453-4057qib7 3727 12 , , , cord-005453-4057qib7 3727 13 including include VBG cord-005453-4057qib7 3727 14 abnormalities abnormality NNS cord-005453-4057qib7 3727 15 in in IN cord-005453-4057qib7 3727 16 phosphocalcic phosphocalcic NN cord-005453-4057qib7 3727 17 metabolism metabolism NN cord-005453-4057qib7 3727 18 and and CC cord-005453-4057qib7 3727 19 bone bone NN cord-005453-4057qib7 3727 20 disease disease NN cord-005453-4057qib7 3727 21 . . . cord-005453-4057qib7 3728 1 Rapid rapid JJ cord-005453-4057qib7 3728 2 and and CC cord-005453-4057qib7 3728 3 progressive progressive JJ cord-005453-4057qib7 3728 4 bone bone NN cord-005453-4057qib7 3728 5 loss loss NN cord-005453-4057qib7 3728 6 occurs occur VBZ cord-005453-4057qib7 3728 7 within within IN cord-005453-4057qib7 3728 8 the the DT cord-005453-4057qib7 3728 9 first first JJ cord-005453-4057qib7 3728 10 6 6 CD cord-005453-4057qib7 3728 11 - - SYM cord-005453-4057qib7 3728 12 12 12 CD cord-005453-4057qib7 3728 13 months month NNS cord-005453-4057qib7 3728 14 after after IN cord-005453-4057qib7 3728 15 transplant transplant NN cord-005453-4057qib7 3728 16 , , , cord-005453-4057qib7 3728 17 and and CC cord-005453-4057qib7 3728 18 this this DT cord-005453-4057qib7 3728 19 is be VBZ cord-005453-4057qib7 3728 20 followed follow VBN cord-005453-4057qib7 3728 21 by by IN cord-005453-4057qib7 3728 22 a a DT cord-005453-4057qib7 3728 23 slow slow JJ cord-005453-4057qib7 3728 24 process process NN cord-005453-4057qib7 3728 25 of of IN cord-005453-4057qib7 3728 26 recovery recovery NN cord-005453-4057qib7 3728 27 , , , cord-005453-4057qib7 3728 28 with with IN cord-005453-4057qib7 3728 29 bone bone NN cord-005453-4057qib7 3728 30 loss loss NN cord-005453-4057qib7 3728 31 persisting persist VBG cord-005453-4057qib7 3728 32 for for IN cord-005453-4057qib7 3728 33 48 48 CD cord-005453-4057qib7 3728 34 to to TO cord-005453-4057qib7 3728 35 120 120 CD cord-005453-4057qib7 3728 36 months month NNS cord-005453-4057qib7 3728 37 . . . cord-005453-4057qib7 3729 1 Bone bone NN cord-005453-4057qib7 3729 2 fractures fracture NNS cord-005453-4057qib7 3729 3 can can MD cord-005453-4057qib7 3729 4 worsen worsen VB cord-005453-4057qib7 3729 5 the the DT cord-005453-4057qib7 3729 6 quality quality NN cord-005453-4057qib7 3729 7 of of IN cord-005453-4057qib7 3729 8 life life NN cord-005453-4057qib7 3729 9 of of IN cord-005453-4057qib7 3729 10 alloSCT alloSCT NNP cord-005453-4057qib7 3729 11 survivors survivor NNS cord-005453-4057qib7 3729 12 , , , cord-005453-4057qib7 3729 13 but but CC cord-005453-4057qib7 3729 14 the the DT cord-005453-4057qib7 3729 15 real real JJ cord-005453-4057qib7 3729 16 burden burden NN cord-005453-4057qib7 3729 17 of of IN cord-005453-4057qib7 3729 18 the the DT cord-005453-4057qib7 3729 19 disease disease NN cord-005453-4057qib7 3729 20 is be VBZ cord-005453-4057qib7 3729 21 unknown unknown JJ cord-005453-4057qib7 3729 22 . . . cord-005453-4057qib7 3730 1 The the DT cord-005453-4057qib7 3730 2 objective objective NN cord-005453-4057qib7 3730 3 of of IN cord-005453-4057qib7 3730 4 the the DT cord-005453-4057qib7 3730 5 study study NN cord-005453-4057qib7 3730 6 is be VBZ cord-005453-4057qib7 3730 7 to to TO cord-005453-4057qib7 3730 8 ascertain ascertain VB cord-005453-4057qib7 3730 9 the the DT cord-005453-4057qib7 3730 10 prevalence prevalence NN cord-005453-4057qib7 3730 11 of of IN cord-005453-4057qib7 3730 12 bone bone NN cord-005453-4057qib7 3730 13 pathology pathology NN cord-005453-4057qib7 3730 14 and and CC cord-005453-4057qib7 3730 15 vertebral vertebral JJ cord-005453-4057qib7 3730 16 fractures fracture NNS cord-005453-4057qib7 3730 17 early early RB cord-005453-4057qib7 3730 18 after after IN cord-005453-4057qib7 3730 19 transplant transplant NN cord-005453-4057qib7 3730 20 in in IN cord-005453-4057qib7 3730 21 our -PRON- PRP$ cord-005453-4057qib7 3730 22 center center NN cord-005453-4057qib7 3730 23 . . . cord-005453-4057qib7 3731 1 Methods method NNS cord-005453-4057qib7 3731 2 : : : cord-005453-4057qib7 3731 3 This this DT cord-005453-4057qib7 3731 4 is be VBZ cord-005453-4057qib7 3731 5 a a DT cord-005453-4057qib7 3731 6 retrospective retrospective JJ cord-005453-4057qib7 3731 7 and and CC cord-005453-4057qib7 3731 8 observational observational JJ cord-005453-4057qib7 3731 9 study study NN cord-005453-4057qib7 3731 10 . . . cord-005453-4057qib7 3732 1 Forty forty CD cord-005453-4057qib7 3732 2 - - HYPH cord-005453-4057qib7 3732 3 nine nine CD cord-005453-4057qib7 3732 4 patients patient NNS cord-005453-4057qib7 3732 5 ( ( -LRB- cord-005453-4057qib7 3732 6 25 25 CD cord-005453-4057qib7 3732 7 male/24 male/24 NNP cord-005453-4057qib7 3732 8 female female JJ cord-005453-4057qib7 3732 9 , , , cord-005453-4057qib7 3732 10 median median JJ cord-005453-4057qib7 3732 11 age age NN cord-005453-4057qib7 3732 12 54y 54y NNS cord-005453-4057qib7 3732 13 , , , cord-005453-4057qib7 3732 14 range range VBP cord-005453-4057qib7 3732 15 19 19 CD cord-005453-4057qib7 3732 16 - - SYM cord-005453-4057qib7 3732 17 69 69 CD cord-005453-4057qib7 3732 18 ) ) -RRB- cord-005453-4057qib7 3732 19 that that WDT cord-005453-4057qib7 3732 20 underwent undergo VBD cord-005453-4057qib7 3732 21 alloSCT alloSCT NNP cord-005453-4057qib7 3732 22 were be VBD cord-005453-4057qib7 3732 23 included include VBN cord-005453-4057qib7 3732 24 in in IN cord-005453-4057qib7 3732 25 the the DT cord-005453-4057qib7 3732 26 study study NN cord-005453-4057qib7 3732 27 in in IN cord-005453-4057qib7 3732 28 the the DT cord-005453-4057qib7 3732 29 period period NN cord-005453-4057qib7 3732 30 of of IN cord-005453-4057qib7 3732 31 6 6 CD cord-005453-4057qib7 3732 32 to to TO cord-005453-4057qib7 3732 33 24 24 CD cord-005453-4057qib7 3732 34 months month NNS cord-005453-4057qib7 3732 35 after after IN cord-005453-4057qib7 3732 36 transplant transplant NN cord-005453-4057qib7 3732 37 ( ( -LRB- cord-005453-4057qib7 3732 38 May May NNP cord-005453-4057qib7 3732 39 2016-December 2016-december CD cord-005453-4057qib7 3732 40 2017 2017 CD cord-005453-4057qib7 3732 41 ) ) -RRB- cord-005453-4057qib7 3732 42 . . . cord-005453-4057qib7 3733 1 Pre pre JJ cord-005453-4057qib7 3733 2 - - JJ cord-005453-4057qib7 3733 3 and and CC cord-005453-4057qib7 3733 4 post post JJ cord-005453-4057qib7 3733 5 - - JJ cord-005453-4057qib7 3733 6 transplant transplant JJ cord-005453-4057qib7 3733 7 risk risk NN cord-005453-4057qib7 3733 8 factors factor NNS cord-005453-4057qib7 3733 9 associated associate VBN cord-005453-4057qib7 3733 10 with with IN cord-005453-4057qib7 3733 11 bone bone NN cord-005453-4057qib7 3733 12 disease disease NN cord-005453-4057qib7 3733 13 were be VBD cord-005453-4057qib7 3733 14 recorded record VBN cord-005453-4057qib7 3733 15 : : : cord-005453-4057qib7 3734 1 age age NN cord-005453-4057qib7 3734 2 > > XX cord-005453-4057qib7 3734 3 65 65 CD cord-005453-4057qib7 3734 4 years year NNS cord-005453-4057qib7 3734 5 , , , cord-005453-4057qib7 3734 6 female female JJ cord-005453-4057qib7 3734 7 sex sex NN cord-005453-4057qib7 3734 8 , , , cord-005453-4057qib7 3734 9 menopause menopause NN cord-005453-4057qib7 3734 10 , , , cord-005453-4057qib7 3734 11 hormone hormone NN cord-005453-4057qib7 3734 12 replacement replacement NN cord-005453-4057qib7 3734 13 therapy therapy NN cord-005453-4057qib7 3734 14 , , , cord-005453-4057qib7 3734 15 previous previous JJ cord-005453-4057qib7 3734 16 treatment treatment NN cord-005453-4057qib7 3734 17 with with IN cord-005453-4057qib7 3734 18 steroids steroid NNS cord-005453-4057qib7 3734 19 , , , cord-005453-4057qib7 3734 20 previous previous JJ cord-005453-4057qib7 3734 21 fractures fracture NNS cord-005453-4057qib7 3734 22 , , , cord-005453-4057qib7 3734 23 weight weight NN cord-005453-4057qib7 3734 24 < < XX cord-005453-4057qib7 3734 25 40 40 CD cord-005453-4057qib7 3734 26 kg kg NNS cord-005453-4057qib7 3734 27 , , , cord-005453-4057qib7 3734 28 BMI BMI NNP cord-005453-4057qib7 3734 29 < < XX cord-005453-4057qib7 3734 30 20 20 CD cord-005453-4057qib7 3734 31 - - SYM cord-005453-4057qib7 3734 32 25 25 CD cord-005453-4057qib7 3734 33 , , , cord-005453-4057qib7 3734 34 low low JJ cord-005453-4057qib7 3734 35 physical physical JJ cord-005453-4057qib7 3734 36 activity activity NN cord-005453-4057qib7 3734 37 , , , cord-005453-4057qib7 3734 38 low low JJ cord-005453-4057qib7 3734 39 calcium calcium NN cord-005453-4057qib7 3734 40 intake intake NN cord-005453-4057qib7 3734 41 , , , cord-005453-4057qib7 3734 42 smoking smoking NN cord-005453-4057qib7 3734 43 , , , cord-005453-4057qib7 3734 44 alcohol alcohol NN cord-005453-4057qib7 3734 45 intake intake NN cord-005453-4057qib7 3734 46 , , , cord-005453-4057qib7 3734 47 and and CC cord-005453-4057qib7 3734 48 history history NN cord-005453-4057qib7 3734 49 of of IN cord-005453-4057qib7 3734 50 femoral femoral JJ cord-005453-4057qib7 3734 51 fractures fracture NNS cord-005453-4057qib7 3734 52 in in IN cord-005453-4057qib7 3734 53 parents parent NNS cord-005453-4057qib7 3734 54 . . . cord-005453-4057qib7 3735 1 In in IN cord-005453-4057qib7 3735 2 all all DT cord-005453-4057qib7 3735 3 patients patient NNS cord-005453-4057qib7 3735 4 laboratory laboratory NN cord-005453-4057qib7 3735 5 data datum NNS cord-005453-4057qib7 3735 6 ( ( -LRB- cord-005453-4057qib7 3735 7 including include VBG cord-005453-4057qib7 3735 8 serum serum NN cord-005453-4057qib7 3735 9 calcium calcium NN cord-005453-4057qib7 3735 10 , , , cord-005453-4057qib7 3735 11 25-hydroxyvitamin 25-hydroxyvitamin CD cord-005453-4057qib7 3735 12 D d NN cord-005453-4057qib7 3735 13 , , , cord-005453-4057qib7 3735 14 and and CC cord-005453-4057qib7 3735 15 PTH PTH NNP cord-005453-4057qib7 3735 16 ) ) -RRB- cord-005453-4057qib7 3735 17 , , , cord-005453-4057qib7 3735 18 lumbar lumbar NN cord-005453-4057qib7 3735 19 and and CC cord-005453-4057qib7 3735 20 femoral femoral JJ cord-005453-4057qib7 3735 21 BMD bmd NN cord-005453-4057qib7 3735 22 ( ( -LRB- cord-005453-4057qib7 3735 23 DXA DXA NNP cord-005453-4057qib7 3735 24 ) ) -RRB- cord-005453-4057qib7 3735 25 , , , cord-005453-4057qib7 3735 26 and and CC cord-005453-4057qib7 3735 27 spinal spinal JJ cord-005453-4057qib7 3735 28 x x NN cord-005453-4057qib7 3735 29 - - NN cord-005453-4057qib7 3735 30 ray ray NN cord-005453-4057qib7 3735 31 were be VBD cord-005453-4057qib7 3735 32 also also RB cord-005453-4057qib7 3735 33 evaluated evaluate VBN cord-005453-4057qib7 3735 34 . . . cord-005453-4057qib7 3736 1 A a DT cord-005453-4057qib7 3736 2 vertebral vertebral JJ cord-005453-4057qib7 3736 3 fracture fracture NN cord-005453-4057qib7 3736 4 was be VBD cord-005453-4057qib7 3736 5 defined define VBN cord-005453-4057qib7 3736 6 as as IN cord-005453-4057qib7 3736 7 a a DT cord-005453-4057qib7 3736 8 reduction reduction NN cord-005453-4057qib7 3736 9 of of IN cord-005453-4057qib7 3736 10 > > XX cord-005453-4057qib7 3736 11 20 20 CD cord-005453-4057qib7 3736 12 % % NN cord-005453-4057qib7 3736 13 in in IN cord-005453-4057qib7 3736 14 the the DT cord-005453-4057qib7 3736 15 anterior anterior JJ cord-005453-4057qib7 3736 16 , , , cord-005453-4057qib7 3736 17 middle middle JJ cord-005453-4057qib7 3736 18 or or CC cord-005453-4057qib7 3736 19 posterior posterior JJ cord-005453-4057qib7 3736 20 high high NN cord-005453-4057qib7 3736 21 of of IN cord-005453-4057qib7 3736 22 the the DT cord-005453-4057qib7 3736 23 vertebral vertebral JJ cord-005453-4057qib7 3736 24 body body NN cord-005453-4057qib7 3736 25 . . . cord-005453-4057qib7 3737 1 Results result NNS cord-005453-4057qib7 3737 2 : : : cord-005453-4057qib7 3738 1 We -PRON- PRP cord-005453-4057qib7 3738 2 identified identify VBD cord-005453-4057qib7 3738 3 vertebral vertebral JJ cord-005453-4057qib7 3738 4 fractures fracture NNS cord-005453-4057qib7 3738 5 in in IN cord-005453-4057qib7 3738 6 12 12 CD cord-005453-4057qib7 3738 7 ( ( -LRB- cord-005453-4057qib7 3738 8 24 24 CD cord-005453-4057qib7 3738 9 % % NN cord-005453-4057qib7 3738 10 ) ) -RRB- cord-005453-4057qib7 3738 11 patients patient NNS cord-005453-4057qib7 3738 12 . . . cord-005453-4057qib7 3739 1 Five five CD cord-005453-4057qib7 3739 2 patients patient NNS cord-005453-4057qib7 3739 3 had have VBD cord-005453-4057qib7 3739 4 fractures fracture NNS cord-005453-4057qib7 3739 5 prior prior RB cord-005453-4057qib7 3739 6 to to IN cord-005453-4057qib7 3739 7 transplantation transplantation NN cord-005453-4057qib7 3739 8 , , , cord-005453-4057qib7 3739 9 and and CC cord-005453-4057qib7 3739 10 7 7 CD cord-005453-4057qib7 3739 11 patients patient NNS cord-005453-4057qib7 3739 12 presented present VBD cord-005453-4057qib7 3739 13 " " `` cord-005453-4057qib7 3739 14 de de FW cord-005453-4057qib7 3739 15 novo novo NNP cord-005453-4057qib7 3739 16 " " '' cord-005453-4057qib7 3739 17 vertebral vertebral JJ cord-005453-4057qib7 3739 18 fractures fracture NNS cord-005453-4057qib7 3739 19 following follow VBG cord-005453-4057qib7 3739 20 transplantation transplantation NN cord-005453-4057qib7 3739 21 ; ; : cord-005453-4057qib7 3739 22 therefore therefore RB cord-005453-4057qib7 3739 23 , , , cord-005453-4057qib7 3739 24 the the DT cord-005453-4057qib7 3739 25 prevalence prevalence NN cord-005453-4057qib7 3739 26 of of IN cord-005453-4057qib7 3739 27 " " `` cord-005453-4057qib7 3739 28 de de FW cord-005453-4057qib7 3739 29 novo novo NNP cord-005453-4057qib7 3739 30 " " '' cord-005453-4057qib7 3739 31 postransplant postransplant NN cord-005453-4057qib7 3739 32 fractures fracture NNS cord-005453-4057qib7 3739 33 was be VBD cord-005453-4057qib7 3739 34 7/49 7/49 CD cord-005453-4057qib7 3739 35 ( ( -LRB- cord-005453-4057qib7 3739 36 14 14 CD cord-005453-4057qib7 3739 37 % % NN cord-005453-4057qib7 3739 38 ) ) -RRB- cord-005453-4057qib7 3739 39 . . . cord-005453-4057qib7 3740 1 Most Most JJS cord-005453-4057qib7 3740 2 ( ( -LRB- cord-005453-4057qib7 3740 3 85 85 CD cord-005453-4057qib7 3740 4 % % NN cord-005453-4057qib7 3740 5 ) ) -RRB- cord-005453-4057qib7 3740 6 of of IN cord-005453-4057qib7 3740 7 these these DT cord-005453-4057qib7 3740 8 fractures fracture NNS cord-005453-4057qib7 3740 9 were be VBD cord-005453-4057qib7 3740 10 asymptomatic asymptomatic JJ cord-005453-4057qib7 3740 11 at at IN cord-005453-4057qib7 3740 12 the the DT cord-005453-4057qib7 3740 13 time time NN cord-005453-4057qib7 3740 14 of of IN cord-005453-4057qib7 3740 15 diagnosis diagnosis NN cord-005453-4057qib7 3740 16 . . . cord-005453-4057qib7 3741 1 Most Most JJS cord-005453-4057qib7 3741 2 patients patient NNS cord-005453-4057qib7 3741 3 ( ( -LRB- cord-005453-4057qib7 3741 4 64 64 CD cord-005453-4057qib7 3741 5 % % NN cord-005453-4057qib7 3741 6 ) ) -RRB- cord-005453-4057qib7 3741 7 with with IN cord-005453-4057qib7 3741 8 vertebral vertebral JJ cord-005453-4057qib7 3741 9 fractures fracture NNS cord-005453-4057qib7 3741 10 had have VBD cord-005453-4057qib7 3741 11 > > XX cord-005453-4057qib7 3741 12 3 3 CD cord-005453-4057qib7 3741 13 pre pre JJ cord-005453-4057qib7 3741 14 - - JJ cord-005453-4057qib7 3741 15 SCT sct JJ cord-005453-4057qib7 3741 16 risk risk NN cord-005453-4057qib7 3741 17 factors factor NNS cord-005453-4057qib7 3741 18 ( ( -LRB- cord-005453-4057qib7 3741 19 median median JJ cord-005453-4057qib7 3741 20 risk risk NN cord-005453-4057qib7 3741 21 factors factor NNS cord-005453-4057qib7 3741 22 pre pre VBP cord-005453-4057qib7 3741 23 - - JJ cord-005453-4057qib7 3741 24 SCT SCT NNP cord-005453-4057qib7 3741 25 3 3 CD cord-005453-4057qib7 3741 26 , , , cord-005453-4057qib7 3741 27 range range NNP cord-005453-4057qib7 3741 28 2 2 CD cord-005453-4057qib7 3741 29 - - SYM cord-005453-4057qib7 3741 30 6 6 CD cord-005453-4057qib7 3741 31 ) ) -RRB- cord-005453-4057qib7 3741 32 , , , cord-005453-4057qib7 3741 33 the the DT cord-005453-4057qib7 3741 34 most most RBS cord-005453-4057qib7 3741 35 frequent frequent JJ cord-005453-4057qib7 3741 36 being be VBG cord-005453-4057qib7 3741 37 low low JJ cord-005453-4057qib7 3741 38 calcium calcium NN cord-005453-4057qib7 3741 39 intake intake NN cord-005453-4057qib7 3741 40 , , , cord-005453-4057qib7 3741 41 steroid steroid NN cord-005453-4057qib7 3741 42 exposure exposure NN cord-005453-4057qib7 3741 43 , , , cord-005453-4057qib7 3741 44 presence presence NN cord-005453-4057qib7 3741 45 of of IN cord-005453-4057qib7 3741 46 previous previous JJ cord-005453-4057qib7 3741 47 fractures fracture NNS cord-005453-4057qib7 3741 48 , , , cord-005453-4057qib7 3741 49 and and CC cord-005453-4057qib7 3741 50 menopause menopause NN cord-005453-4057qib7 3741 51 . . . cord-005453-4057qib7 3742 1 Those those DT cord-005453-4057qib7 3742 2 patients patient NNS cord-005453-4057qib7 3742 3 with with IN cord-005453-4057qib7 3742 4 fractures fracture NNS cord-005453-4057qib7 3742 5 and and CC cord-005453-4057qib7 3742 6 less less JJR cord-005453-4057qib7 3742 7 than than IN cord-005453-4057qib7 3742 8 3 3 CD cord-005453-4057qib7 3742 9 risk risk NN cord-005453-4057qib7 3742 10 factors factor NNS cord-005453-4057qib7 3742 11 pre pre VBP cord-005453-4057qib7 3742 12 - - NN cord-005453-4057qib7 3742 13 TPH TPH NNP cord-005453-4057qib7 3742 14 , , , cord-005453-4057qib7 3742 15 added add VBD cord-005453-4057qib7 3742 16 new new JJ cord-005453-4057qib7 3742 17 risk risk NN cord-005453-4057qib7 3742 18 factors factor NNS cord-005453-4057qib7 3742 19 after after IN cord-005453-4057qib7 3742 20 transplant transplant NN cord-005453-4057qib7 3742 21 , , , cord-005453-4057qib7 3742 22 mainly mainly RB cord-005453-4057qib7 3742 23 steroid steroid JJ cord-005453-4057qib7 3742 24 treatment treatment NN cord-005453-4057qib7 3742 25 . . . cord-005453-4057qib7 3743 1 Forty forty CD cord-005453-4057qib7 3743 2 - - HYPH cord-005453-4057qib7 3743 3 four four CD cord-005453-4057qib7 3743 4 patients patient NNS cord-005453-4057qib7 3743 5 ( ( -LRB- cord-005453-4057qib7 3743 6 90 90 CD cord-005453-4057qib7 3743 7 % % NN cord-005453-4057qib7 3743 8 ) ) -RRB- cord-005453-4057qib7 3743 9 had have VBD cord-005453-4057qib7 3743 10 vitamin vitamin NN cord-005453-4057qib7 3743 11 D d NN cord-005453-4057qib7 3743 12 insufficiency insufficiency NN cord-005453-4057qib7 3743 13 ( ( -LRB- cord-005453-4057qib7 3743 14 < < NNP cord-005453-4057qib7 3743 15 30ng 30ng NNP cord-005453-4057qib7 3743 16 / / SYM cord-005453-4057qib7 3743 17 ml ml NNP cord-005453-4057qib7 3743 18 ) ) -RRB- cord-005453-4057qib7 3743 19 , , , cord-005453-4057qib7 3743 20 15 15 CD cord-005453-4057qib7 3743 21 ( ( -LRB- cord-005453-4057qib7 3743 22 32 32 CD cord-005453-4057qib7 3743 23 % % NN cord-005453-4057qib7 3743 24 ) ) -RRB- cord-005453-4057qib7 3743 25 had have VBD cord-005453-4057qib7 3743 26 osteopenia osteopenia VBN cord-005453-4057qib7 3743 27 and and CC cord-005453-4057qib7 3743 28 9 9 CD cord-005453-4057qib7 3743 29 ( ( -LRB- cord-005453-4057qib7 3743 30 18 18 CD cord-005453-4057qib7 3743 31 % % NN cord-005453-4057qib7 3743 32 ) ) -RRB- cord-005453-4057qib7 3743 33 had have VBD cord-005453-4057qib7 3743 34 osteoporosis osteoporosis NN cord-005453-4057qib7 3743 35 . . . cord-005453-4057qib7 3744 1 Vitamin vitamin NN cord-005453-4057qib7 3744 2 D d NN cord-005453-4057qib7 3744 3 insufficiency insufficiency NN cord-005453-4057qib7 3744 4 and and CC cord-005453-4057qib7 3744 5 bone bone NN cord-005453-4057qib7 3744 6 disease disease NN cord-005453-4057qib7 3744 7 were be VBD cord-005453-4057qib7 3744 8 more more RBR cord-005453-4057qib7 3744 9 frequent frequent JJ cord-005453-4057qib7 3744 10 in in IN cord-005453-4057qib7 3744 11 women woman NNS cord-005453-4057qib7 3744 12 than than IN cord-005453-4057qib7 3744 13 in in IN cord-005453-4057qib7 3744 14 men man NNS cord-005453-4057qib7 3744 15 ( ( -LRB- cord-005453-4057qib7 3744 16 98 98 CD cord-005453-4057qib7 3744 17 % % NN cord-005453-4057qib7 3744 18 vs. vs. IN cord-005453-4057qib7 3744 19 84 84 CD cord-005453-4057qib7 3744 20 % % NN cord-005453-4057qib7 3744 21 for for IN cord-005453-4057qib7 3744 22 vitamin vitamin NN cord-005453-4057qib7 3744 23 D d NN cord-005453-4057qib7 3744 24 , , , cord-005453-4057qib7 3744 25 37 37 CD cord-005453-4057qib7 3744 26 % % NN cord-005453-4057qib7 3744 27 vs. vs. IN cord-005453-4057qib7 3744 28 28 28 CD cord-005453-4057qib7 3744 29 % % NN cord-005453-4057qib7 3744 30 for for IN cord-005453-4057qib7 3744 31 osteopenia osteopenia NN cord-005453-4057qib7 3744 32 , , , cord-005453-4057qib7 3744 33 29 29 CD cord-005453-4057qib7 3744 34 % % NN cord-005453-4057qib7 3744 35 vs. vs. IN cord-005453-4057qib7 3744 36 8 8 CD cord-005453-4057qib7 3744 37 % % NN cord-005453-4057qib7 3744 38 for for IN cord-005453-4057qib7 3744 39 osteoporosis osteoporosis NN cord-005453-4057qib7 3744 40 , , , cord-005453-4057qib7 3744 41 and and CC cord-005453-4057qib7 3744 42 25 25 CD cord-005453-4057qib7 3744 43 % % NN cord-005453-4057qib7 3744 44 vs. vs. CC cord-005453-4057qib7 3744 45 20 20 CD cord-005453-4057qib7 3744 46 % % NN cord-005453-4057qib7 3744 47 for for IN cord-005453-4057qib7 3744 48 vertebral vertebral JJ cord-005453-4057qib7 3744 49 fractures fracture NNS cord-005453-4057qib7 3744 50 , , , cord-005453-4057qib7 3744 51 respectively respectively RB cord-005453-4057qib7 3744 52 ) ) -RRB- cord-005453-4057qib7 3744 53 . . . cord-005453-4057qib7 3745 1 Conclusions conclusion NNS cord-005453-4057qib7 3745 2 : : : cord-005453-4057qib7 3746 1 The the DT cord-005453-4057qib7 3746 2 prevalence prevalence NN cord-005453-4057qib7 3746 3 of of IN cord-005453-4057qib7 3746 4 post post JJ cord-005453-4057qib7 3746 5 - - JJ cord-005453-4057qib7 3746 6 transplant transplant JJ cord-005453-4057qib7 3746 7 bone bone NN cord-005453-4057qib7 3746 8 disease disease NN cord-005453-4057qib7 3746 9 and and CC cord-005453-4057qib7 3746 10 vertebral vertebral JJ cord-005453-4057qib7 3746 11 fractures fracture NNS cord-005453-4057qib7 3746 12 in in IN cord-005453-4057qib7 3746 13 our -PRON- PRP$ cord-005453-4057qib7 3746 14 series series NN cord-005453-4057qib7 3746 15 is be VBZ cord-005453-4057qib7 3746 16 high high JJ cord-005453-4057qib7 3746 17 . . . cord-005453-4057qib7 3747 1 Most Most JJS cord-005453-4057qib7 3747 2 fractures fracture NNS cord-005453-4057qib7 3747 3 appearing appear VBG cord-005453-4057qib7 3747 4 " " `` cord-005453-4057qib7 3747 5 de de FW cord-005453-4057qib7 3747 6 novo novo NNP cord-005453-4057qib7 3747 7 " " '' cord-005453-4057qib7 3747 8 after after IN cord-005453-4057qib7 3747 9 alloSCT alloSCT NNP cord-005453-4057qib7 3747 10 were be VBD cord-005453-4057qib7 3747 11 asymptomatic asymptomatic JJ cord-005453-4057qib7 3747 12 and and CC cord-005453-4057qib7 3747 13 were be VBD cord-005453-4057qib7 3747 14 diagnosed diagnose VBN cord-005453-4057qib7 3747 15 by by IN cord-005453-4057qib7 3747 16 x x NN cord-005453-4057qib7 3747 17 - - NN cord-005453-4057qib7 3747 18 ray ray NN cord-005453-4057qib7 3747 19 . . . cord-005453-4057qib7 3748 1 Patients patient NNS cord-005453-4057qib7 3748 2 who who WP cord-005453-4057qib7 3748 3 presented present VBD cord-005453-4057qib7 3748 4 vertebral vertebral JJ cord-005453-4057qib7 3748 5 fractures fracture NNS cord-005453-4057qib7 3748 6 frequently frequently RB cord-005453-4057qib7 3748 7 had have VBD cord-005453-4057qib7 3748 8 more more JJR cord-005453-4057qib7 3748 9 than than IN cord-005453-4057qib7 3748 10 3 3 CD cord-005453-4057qib7 3748 11 risk risk NN cord-005453-4057qib7 3748 12 factors factor NNS cord-005453-4057qib7 3748 13 identified identify VBD cord-005453-4057qib7 3748 14 pre pre JJ cord-005453-4057qib7 3748 15 - - JJ cord-005453-4057qib7 3748 16 SCT SCT NNP cord-005453-4057qib7 3748 17 . . . cord-005453-4057qib7 3749 1 Patients patient NNS cord-005453-4057qib7 3749 2 undergoing undergo VBG cord-005453-4057qib7 3749 3 alloSCT alloSCT NNP cord-005453-4057qib7 3749 4 should should MD cord-005453-4057qib7 3749 5 have have VB cord-005453-4057qib7 3749 6 their -PRON- PRP$ cord-005453-4057qib7 3749 7 bone bone NN cord-005453-4057qib7 3749 8 health health NN cord-005453-4057qib7 3749 9 assessed assess VBN cord-005453-4057qib7 3749 10 early early RB cord-005453-4057qib7 3749 11 in in IN cord-005453-4057qib7 3749 12 their -PRON- PRP$ cord-005453-4057qib7 3749 13 treatment treatment NN cord-005453-4057qib7 3749 14 and and CC cord-005453-4057qib7 3749 15 , , , cord-005453-4057qib7 3749 16 if if IN cord-005453-4057qib7 3749 17 indicated indicate VBN cord-005453-4057qib7 3749 18 , , , cord-005453-4057qib7 3749 19 should should MD cord-005453-4057qib7 3749 20 start start VB cord-005453-4057qib7 3749 21 preventative preventative JJ cord-005453-4057qib7 3749 22 therapy therapy NN cord-005453-4057qib7 3749 23 to to TO cord-005453-4057qib7 3749 24 avoid avoid VB cord-005453-4057qib7 3749 25 bone bone NN cord-005453-4057qib7 3749 26 loss loss NN cord-005453-4057qib7 3749 27 and and CC cord-005453-4057qib7 3749 28 fractures fracture NNS cord-005453-4057qib7 3749 29 . . . cord-005453-4057qib7 3750 1 Other other JJ cord-005453-4057qib7 3750 2 measures measure NNS cord-005453-4057qib7 3750 3 such such JJ cord-005453-4057qib7 3750 4 as as IN cord-005453-4057qib7 3750 5 physical physical JJ cord-005453-4057qib7 3750 6 exercise exercise NN cord-005453-4057qib7 3750 7 , , , cord-005453-4057qib7 3750 8 vitamin vitamin NN cord-005453-4057qib7 3750 9 D d NN cord-005453-4057qib7 3750 10 and and CC cord-005453-4057qib7 3750 11 calcium calcium NN cord-005453-4057qib7 3750 12 supplementation supplementation NN cord-005453-4057qib7 3750 13 , , , cord-005453-4057qib7 3750 14 and and CC cord-005453-4057qib7 3750 15 DXA DXA NNP cord-005453-4057qib7 3750 16 and and CC cord-005453-4057qib7 3750 17 spinal spinal JJ cord-005453-4057qib7 3750 18 x x NN cord-005453-4057qib7 3750 19 - - NN cord-005453-4057qib7 3750 20 ray ray NN cord-005453-4057qib7 3750 21 at at IN cord-005453-4057qib7 3750 22 baseline baseline NN cord-005453-4057qib7 3750 23 and and CC cord-005453-4057qib7 3750 24 following follow VBG cord-005453-4057qib7 3750 25 transplantation transplantation NN cord-005453-4057qib7 3750 26 are be VBP cord-005453-4057qib7 3750 27 also also RB cord-005453-4057qib7 3750 28 highly highly RB cord-005453-4057qib7 3750 29 recommended recommend VBN cord-005453-4057qib7 3750 30 . . . cord-005453-4057qib7 3751 1 Disclosure disclosure NN cord-005453-4057qib7 3751 2 : : : cord-005453-4057qib7 3752 1 María María NNP cord-005453-4057qib7 3752 2 Suárez Suárez NNP cord-005453-4057qib7 3752 3 - - HYPH cord-005453-4057qib7 3752 4 Lledó Lledó NNP cord-005453-4057qib7 3752 5 received receive VBD cord-005453-4057qib7 3752 6 a a DT cord-005453-4057qib7 3752 7 grant grant NN cord-005453-4057qib7 3752 8 from from IN cord-005453-4057qib7 3752 9 DKMS DKMS NNP cord-005453-4057qib7 3752 10 - - HYPH cord-005453-4057qib7 3752 11 Spain Spain NNP cord-005453-4057qib7 3752 12 Foundation Foundation NNP cord-005453-4057qib7 3752 13 . . . cord-005453-4057qib7 3753 1 Other other JJ cord-005453-4057qib7 3753 2 Authors author NNS cord-005453-4057qib7 3753 3 have have VBP cord-005453-4057qib7 3753 4 Nothing nothing NN cord-005453-4057qib7 3753 5 to to TO cord-005453-4057qib7 3753 6 declare declare VB cord-005453-4057qib7 3753 7 The the DT cord-005453-4057qib7 3753 8 use use NN cord-005453-4057qib7 3753 9 of of IN cord-005453-4057qib7 3753 10 G G NNP cord-005453-4057qib7 3753 11 - - HYPH cord-005453-4057qib7 3753 12 CSF CSF NNP cord-005453-4057qib7 3753 13 in in IN cord-005453-4057qib7 3753 14 selected select VBN cord-005453-4057qib7 3753 15 patients patient NNS cord-005453-4057qib7 3753 16 after after IN cord-005453-4057qib7 3753 17 autologous autologous JJ cord-005453-4057qib7 3753 18 stem stem NN cord-005453-4057qib7 3753 19 cell cell NN cord-005453-4057qib7 3753 20 transplantation transplantation NN cord-005453-4057qib7 3753 21 is be VBZ cord-005453-4057qib7 3753 22 associated associate VBN cord-005453-4057qib7 3753 23 with with IN cord-005453-4057qib7 3753 24 low low JJ cord-005453-4057qib7 3753 25 incidence incidence NN cord-005453-4057qib7 3753 26 of of IN cord-005453-4057qib7 3753 27 engraftment engraftment NN cord-005453-4057qib7 3753 28 syndrome syndrome NN cord-005453-4057qib7 3753 29 Background Background NNP cord-005453-4057qib7 3753 30 : : : cord-005453-4057qib7 3754 1 The the DT cord-005453-4057qib7 3754 2 use use NN cord-005453-4057qib7 3754 3 of of IN cord-005453-4057qib7 3754 4 G G NNP cord-005453-4057qib7 3754 5 - - HYPH cord-005453-4057qib7 3754 6 CSF CSF NNP cord-005453-4057qib7 3754 7 after after IN cord-005453-4057qib7 3754 8 autologous autologous JJ cord-005453-4057qib7 3754 9 stem stem NN cord-005453-4057qib7 3754 10 cell cell NN cord-005453-4057qib7 3754 11 transplantation transplantation NN cord-005453-4057qib7 3754 12 ( ( -LRB- cord-005453-4057qib7 3754 13 ASCT ASCT NNP cord-005453-4057qib7 3754 14 ) ) -RRB- cord-005453-4057qib7 3754 15 accelerates accelerate VBZ cord-005453-4057qib7 3754 16 neutrophil neutrophil NN cord-005453-4057qib7 3754 17 recovery recovery NN cord-005453-4057qib7 3754 18 , , , cord-005453-4057qib7 3754 19 however however RB cord-005453-4057qib7 3754 20 it -PRON- PRP cord-005453-4057qib7 3754 21 has have VBZ cord-005453-4057qib7 3754 22 been be VBN cord-005453-4057qib7 3754 23 related relate VBN cord-005453-4057qib7 3754 24 to to IN cord-005453-4057qib7 3754 25 an an DT cord-005453-4057qib7 3754 26 increased increase VBN cord-005453-4057qib7 3754 27 risk risk NN cord-005453-4057qib7 3754 28 of of IN cord-005453-4057qib7 3754 29 engraftment engraftment NNP cord-005453-4057qib7 3754 30 syndrome syndrome NN cord-005453-4057qib7 3754 31 ( ( -LRB- cord-005453-4057qib7 3754 32 ES ES NNP cord-005453-4057qib7 3754 33 ) ) -RRB- cord-005453-4057qib7 3754 34 development development NN cord-005453-4057qib7 3754 35 in in IN cord-005453-4057qib7 3754 36 some some DT cord-005453-4057qib7 3754 37 studies study NNS cord-005453-4057qib7 3754 38 . . . cord-005453-4057qib7 3755 1 For for IN cord-005453-4057qib7 3755 2 this this DT cord-005453-4057qib7 3755 3 reason reason NN cord-005453-4057qib7 3755 4 , , , cord-005453-4057qib7 3755 5 we -PRON- PRP cord-005453-4057qib7 3755 6 do do VBP cord-005453-4057qib7 3755 7 not not RB cord-005453-4057qib7 3755 8 routinely routinely RB cord-005453-4057qib7 3755 9 prescribe prescribe VB cord-005453-4057qib7 3755 10 G G NNP cord-005453-4057qib7 3755 11 - - HYPH cord-005453-4057qib7 3755 12 CSF CSF NNP cord-005453-4057qib7 3755 13 after after IN cord-005453-4057qib7 3755 14 ASCT ASCT NNP cord-005453-4057qib7 3756 1 and and CC cord-005453-4057qib7 3756 2 we -PRON- PRP cord-005453-4057qib7 3756 3 only only RB cord-005453-4057qib7 3756 4 use use VBP cord-005453-4057qib7 3756 5 it -PRON- PRP cord-005453-4057qib7 3756 6 in in IN cord-005453-4057qib7 3756 7 patients patient NNS cord-005453-4057qib7 3756 8 with with IN cord-005453-4057qib7 3756 9 significant significant JJ cord-005453-4057qib7 3756 10 complications complication NNS cord-005453-4057qib7 3756 11 ( ( -LRB- cord-005453-4057qib7 3756 12 enterocolitis enterocolitis NN cord-005453-4057qib7 3756 13 , , , cord-005453-4057qib7 3756 14 severe severe JJ cord-005453-4057qib7 3756 15 sepsis sepsis NN cord-005453-4057qib7 3756 16 , , , cord-005453-4057qib7 3756 17 atrial atrial JJ cord-005453-4057qib7 3756 18 fibrillation fibrillation NN cord-005453-4057qib7 3756 19 ) ) -RRB- cord-005453-4057qib7 3756 20 after after IN cord-005453-4057qib7 3756 21 stem stem NN cord-005453-4057qib7 3756 22 cell cell NN cord-005453-4057qib7 3756 23 infusion infusion NN cord-005453-4057qib7 3756 24 . . . cord-005453-4057qib7 3757 1 The the DT cord-005453-4057qib7 3757 2 main main JJ cord-005453-4057qib7 3757 3 objective objective NN cord-005453-4057qib7 3757 4 of of IN cord-005453-4057qib7 3757 5 this this DT cord-005453-4057qib7 3757 6 study study NN cord-005453-4057qib7 3757 7 is be VBZ cord-005453-4057qib7 3757 8 to to TO cord-005453-4057qib7 3757 9 evaluate evaluate VB cord-005453-4057qib7 3757 10 the the DT cord-005453-4057qib7 3757 11 incidence incidence NN cord-005453-4057qib7 3757 12 of of IN cord-005453-4057qib7 3757 13 ES ES NNP cord-005453-4057qib7 3757 14 in in IN cord-005453-4057qib7 3757 15 patients patient NNS cord-005453-4057qib7 3757 16 who who WP cord-005453-4057qib7 3757 17 receive receive VBP cord-005453-4057qib7 3757 18 ASCT ASCT NNP cord-005453-4057qib7 3757 19 for for IN cord-005453-4057qib7 3757 20 monoclonal monoclonal JJ cord-005453-4057qib7 3757 21 gammopathies gammopathy NNS cord-005453-4057qib7 3757 22 ( ( -LRB- cord-005453-4057qib7 3757 23 MG MG NNP cord-005453-4057qib7 3757 24 ) ) -RRB- cord-005453-4057qib7 3757 25 , , , cord-005453-4057qib7 3757 26 non non JJ cord-005453-4057qib7 3757 27 - - JJ cord-005453-4057qib7 3757 28 Hodgkin Hodgkin NNP cord-005453-4057qib7 3757 29 lymphoma lymphoma NN cord-005453-4057qib7 3757 30 ( ( -LRB- cord-005453-4057qib7 3757 31 NHL NHL NNP cord-005453-4057qib7 3757 32 ) ) -RRB- cord-005453-4057qib7 3757 33 and and CC cord-005453-4057qib7 3757 34 Hodgkin Hodgkin NNP cord-005453-4057qib7 3757 35 lymphoma lymphoma NN cord-005453-4057qib7 3757 36 ( ( -LRB- cord-005453-4057qib7 3757 37 HL HL NNP cord-005453-4057qib7 3757 38 ) ) -RRB- cord-005453-4057qib7 3757 39 and and CC cord-005453-4057qib7 3757 40 receive receive VB cord-005453-4057qib7 3757 41 G G NNP cord-005453-4057qib7 3757 42 - - HYPH cord-005453-4057qib7 3757 43 CSF CSF NNP cord-005453-4057qib7 3757 44 only only RB cord-005453-4057qib7 3757 45 if if IN cord-005453-4057qib7 3757 46 needed need VBN cord-005453-4057qib7 3757 47 . . . cord-005453-4057qib7 3758 1 As as IN cord-005453-4057qib7 3758 2 secondary secondary JJ cord-005453-4057qib7 3758 3 objectives objective NNS cord-005453-4057qib7 3758 4 we -PRON- PRP cord-005453-4057qib7 3758 5 evaluate evaluate VBP cord-005453-4057qib7 3758 6 differences difference NNS cord-005453-4057qib7 3758 7 in in IN cord-005453-4057qib7 3758 8 the the DT cord-005453-4057qib7 3758 9 engraftment engraftment NNP cord-005453-4057qib7 3758 10 day day NNP cord-005453-4057qib7 3758 11 as as RB cord-005453-4057qib7 3758 12 well well RB cord-005453-4057qib7 3758 13 as as IN cord-005453-4057qib7 3758 14 the the DT cord-005453-4057qib7 3758 15 length length NN cord-005453-4057qib7 3758 16 of of IN cord-005453-4057qib7 3758 17 inpatient inpatient JJ cord-005453-4057qib7 3758 18 stay stay NN cord-005453-4057qib7 3758 19 . . . cord-005453-4057qib7 3759 1 Methods method NNS cord-005453-4057qib7 3759 2 : : : cord-005453-4057qib7 3759 3 We -PRON- PRP cord-005453-4057qib7 3759 4 retrospectively retrospectively RB cord-005453-4057qib7 3759 5 analyzed analyze VBD cord-005453-4057qib7 3759 6 patients patient NNS cord-005453-4057qib7 3759 7 with with IN cord-005453-4057qib7 3759 8 MG MG NNP cord-005453-4057qib7 3759 9 or or CC cord-005453-4057qib7 3759 10 lymphoma lymphoma NN cord-005453-4057qib7 3759 11 , , , cord-005453-4057qib7 3759 12 who who WP cord-005453-4057qib7 3759 13 underwent undergo VBD cord-005453-4057qib7 3759 14 ASCT ASCT NNP cord-005453-4057qib7 3759 15 conditioned condition VBN cord-005453-4057qib7 3759 16 with with IN cord-005453-4057qib7 3759 17 high high JJ cord-005453-4057qib7 3759 18 dose dose NN cord-005453-4057qib7 3759 19 melphalan melphalan NN cord-005453-4057qib7 3759 20 ( ( -LRB- cord-005453-4057qib7 3759 21 140 140 CD cord-005453-4057qib7 3759 22 - - SYM cord-005453-4057qib7 3759 23 200 200 CD cord-005453-4057qib7 3759 24 mg mg NNP cord-005453-4057qib7 3759 25 / / SYM cord-005453-4057qib7 3759 26 m m NNP cord-005453-4057qib7 3759 27 2 2 CD cord-005453-4057qib7 3759 28 ) ) -RRB- cord-005453-4057qib7 3759 29 or or CC cord-005453-4057qib7 3759 30 BEAM beam NN cord-005453-4057qib7 3759 31 , , , cord-005453-4057qib7 3759 32 respectively respectively RB cord-005453-4057qib7 3759 33 , , , cord-005453-4057qib7 3759 34 between between IN cord-005453-4057qib7 3759 35 2015 2015 CD cord-005453-4057qib7 3759 36 and and CC cord-005453-4057qib7 3759 37 2017 2017 CD cord-005453-4057qib7 3759 38 in in IN cord-005453-4057qib7 3759 39 our -PRON- PRP$ cord-005453-4057qib7 3759 40 center center NN cord-005453-4057qib7 3759 41 . . . cord-005453-4057qib7 3760 1 Specific specific JJ cord-005453-4057qib7 3760 2 clinical clinical JJ cord-005453-4057qib7 3760 3 features feature NNS cord-005453-4057qib7 3760 4 for for IN cord-005453-4057qib7 3760 5 ES ES NNP cord-005453-4057qib7 3760 6 according accord VBG cord-005453-4057qib7 3760 7 to to IN cord-005453-4057qib7 3760 8 Spitzer Spitzer NNP cord-005453-4057qib7 3760 9 and and CC cord-005453-4057qib7 3760 10 Maiolino Maiolino NNP cord-005453-4057qib7 3760 11 criteria criterion NNS cord-005453-4057qib7 3760 12 were be VBD cord-005453-4057qib7 3760 13 evaluated evaluate VBN cord-005453-4057qib7 3760 14 between between IN cord-005453-4057qib7 3760 15 3 3 CD cord-005453-4057qib7 3760 16 days day NNS cord-005453-4057qib7 3760 17 before before RB cord-005453-4057qib7 3760 18 and and CC cord-005453-4057qib7 3760 19 7 7 CD cord-005453-4057qib7 3760 20 days day NNS cord-005453-4057qib7 3760 21 after after IN cord-005453-4057qib7 3760 22 the the DT cord-005453-4057qib7 3760 23 engraftment engraftment NN cord-005453-4057qib7 3760 24 . . . cord-005453-4057qib7 3761 1 Statistical statistical JJ cord-005453-4057qib7 3761 2 analysis analysis NN cord-005453-4057qib7 3761 3 was be VBD cord-005453-4057qib7 3761 4 performed perform VBN cord-005453-4057qib7 3761 5 with with IN cord-005453-4057qib7 3761 6 SPSS SPSS NNP cord-005453-4057qib7 3761 7 v. v. NNP cord-005453-4057qib7 3761 8 15.0 15.0 CD cord-005453-4057qib7 3761 9 . . . cord-005453-4057qib7 3762 1 Results result NNS cord-005453-4057qib7 3762 2 : : : cord-005453-4057qib7 3763 1 Thirty thirty CD cord-005453-4057qib7 3763 2 - - HYPH cord-005453-4057qib7 3763 3 one one CD cord-005453-4057qib7 3763 4 patients patient NNS cord-005453-4057qib7 3763 5 with with IN cord-005453-4057qib7 3763 6 MG MG NNP cord-005453-4057qib7 3763 7 and and CC cord-005453-4057qib7 3763 8 34 34 CD cord-005453-4057qib7 3763 9 patients patient NNS cord-005453-4057qib7 3763 10 with with IN cord-005453-4057qib7 3763 11 lymphoma lymphoma NN cord-005453-4057qib7 3763 12 were be VBD cord-005453-4057qib7 3763 13 analyzed analyze VBN cord-005453-4057qib7 3763 14 . . . cord-005453-4057qib7 3764 1 Median median JJ cord-005453-4057qib7 3764 2 age age NN cord-005453-4057qib7 3764 3 at at IN cord-005453-4057qib7 3764 4 transplant transplant NN cord-005453-4057qib7 3764 5 was be VBD cord-005453-4057qib7 3764 6 56.8 56.8 CD cord-005453-4057qib7 3764 7 years year NNS cord-005453-4057qib7 3764 8 ( ( -LRB- cord-005453-4057qib7 3764 9 48.7 48.7 CD cord-005453-4057qib7 3764 10 - - HYPH cord-005453-4057qib7 3764 11 65.4 65.4 CD cord-005453-4057qib7 3764 12 ) ) -RRB- cord-005453-4057qib7 3764 13 and and CC cord-005453-4057qib7 3764 14 41 41 CD cord-005453-4057qib7 3764 15 patients patient NNS cord-005453-4057qib7 3764 16 ( ( -LRB- cord-005453-4057qib7 3764 17 63.1 63.1 CD cord-005453-4057qib7 3764 18 % % NN cord-005453-4057qib7 3764 19 ) ) -RRB- cord-005453-4057qib7 3764 20 were be VBD cord-005453-4057qib7 3764 21 male male JJ cord-005453-4057qib7 3764 22 . . . cord-005453-4057qib7 3765 1 Median median JJ cord-005453-4057qib7 3765 2 prior prior JJ cord-005453-4057qib7 3765 3 lines line NNS cord-005453-4057qib7 3765 4 of of IN cord-005453-4057qib7 3765 5 treatment treatment NN cord-005453-4057qib7 3765 6 in in IN cord-005453-4057qib7 3765 7 patients patient NNS cord-005453-4057qib7 3765 8 with with IN cord-005453-4057qib7 3765 9 GM GM NNP cord-005453-4057qib7 3765 10 or or CC cord-005453-4057qib7 3765 11 lymphoma lymphoma NN cord-005453-4057qib7 3765 12 were be VBD cord-005453-4057qib7 3765 13 1 1 CD cord-005453-4057qib7 3765 14 ( ( -LRB- cord-005453-4057qib7 3765 15 1 1 CD cord-005453-4057qib7 3765 16 - - SYM cord-005453-4057qib7 3765 17 3 3 CD cord-005453-4057qib7 3765 18 ) ) -RRB- cord-005453-4057qib7 3765 19 and and CC cord-005453-4057qib7 3765 20 2 2 LS cord-005453-4057qib7 3765 21 ( ( -LRB- cord-005453-4057qib7 3765 22 1 1 CD cord-005453-4057qib7 3765 23 - - SYM cord-005453-4057qib7 3765 24 5 5 CD cord-005453-4057qib7 3765 25 ) ) -RRB- cord-005453-4057qib7 3765 26 , , , cord-005453-4057qib7 3765 27 respectively respectively RB cord-005453-4057qib7 3765 28 . . . cord-005453-4057qib7 3766 1 Table table NN cord-005453-4057qib7 3766 2 _SP cord-005453-4057qib7 3766 3 1 1 CD cord-005453-4057qib7 3766 4 shows show VBZ cord-005453-4057qib7 3766 5 patients´characteristics patients´characteristic NNS cord-005453-4057qib7 3766 6 . . . cord-005453-4057qib7 3767 1 Mobilization mobilization NN cord-005453-4057qib7 3767 2 with with IN cord-005453-4057qib7 3767 3 G G NNP cord-005453-4057qib7 3767 4 - - HYPH cord-005453-4057qib7 3767 5 CSF CSF NNP cord-005453-4057qib7 3767 6 ± ± NNP cord-005453-4057qib7 3767 7 Plerixafor Plerixafor NNP cord-005453-4057qib7 3767 8 was be VBD cord-005453-4057qib7 3767 9 performed perform VBN cord-005453-4057qib7 3767 10 in in IN cord-005453-4057qib7 3767 11 27 27 CD cord-005453-4057qib7 3767 12 patients patient NNS cord-005453-4057qib7 3767 13 ( ( -LRB- cord-005453-4057qib7 3767 14 36 36 CD cord-005453-4057qib7 3767 15 % % NN cord-005453-4057qib7 3767 16 ) ) -RRB- cord-005453-4057qib7 3767 17 and and CC cord-005453-4057qib7 3767 18 chemotherapy chemotherapy NN cord-005453-4057qib7 3767 19 + + CC cord-005453-4057qib7 3767 20 G g NN cord-005453-4057qib7 3767 21 - - HYPH cord-005453-4057qib7 3767 22 CSF CSF NNP cord-005453-4057qib7 3767 23 ± ± NNP cord-005453-4057qib7 3767 24 Plerixafor Plerixafor NNP cord-005453-4057qib7 3767 25 in in IN cord-005453-4057qib7 3767 26 38 38 CD cord-005453-4057qib7 3767 27 patients patient NNS cord-005453-4057qib7 3767 28 ( ( -LRB- cord-005453-4057qib7 3767 29 64 64 CD cord-005453-4057qib7 3767 30 % % NN cord-005453-4057qib7 3767 31 ) ) -RRB- cord-005453-4057qib7 3767 32 . . . cord-005453-4057qib7 3768 1 Median median JJ cord-005453-4057qib7 3768 2 CD34 CD34 NNP cord-005453-4057qib7 3769 1 x x LS cord-005453-4057qib7 3770 1 10 10 CD cord-005453-4057qib7 3770 2 6 6 CD cord-005453-4057qib7 3770 3 /Kg /kg NN cord-005453-4057qib7 3770 4 cells cell NNS cord-005453-4057qib7 3770 5 infused infuse VBN cord-005453-4057qib7 3770 6 was be VBD cord-005453-4057qib7 3770 7 3.6 3.6 CD cord-005453-4057qib7 3770 8 ( ( -LRB- cord-005453-4057qib7 3770 9 2.7 2.7 CD cord-005453-4057qib7 3770 10 - - SYM cord-005453-4057qib7 3770 11 5.3 5.3 CD cord-005453-4057qib7 3770 12 ) ) -RRB- cord-005453-4057qib7 3770 13 . . . cord-005453-4057qib7 3771 1 Eleven eleven CD cord-005453-4057qib7 3771 2 patients patient NNS cord-005453-4057qib7 3771 3 ( ( -LRB- cord-005453-4057qib7 3771 4 16.9 16.9 CD cord-005453-4057qib7 3771 5 % % NN cord-005453-4057qib7 3771 6 ) ) -RRB- cord-005453-4057qib7 3771 7 received receive VBD cord-005453-4057qib7 3771 8 G G NNP cord-005453-4057qib7 3771 9 - - HYPH cord-005453-4057qib7 3771 10 CSF CSF NNP cord-005453-4057qib7 3771 11 , , , cord-005453-4057qib7 3771 12 5 5 CD cord-005453-4057qib7 3771 13 due due IN cord-005453-4057qib7 3771 14 to to IN cord-005453-4057qib7 3771 15 infection infection NN cord-005453-4057qib7 3771 16 ( ( -LRB- cord-005453-4057qib7 3771 17 2 2 CD cord-005453-4057qib7 3771 18 enterocolitis enterocolitis NN cord-005453-4057qib7 3771 19 , , , cord-005453-4057qib7 3771 20 1 1 CD cord-005453-4057qib7 3771 21 listeriosis listeriosis NN cord-005453-4057qib7 3771 22 , , , cord-005453-4057qib7 3771 23 1 1 CD cord-005453-4057qib7 3771 24 acute acute JJ cord-005453-4057qib7 3771 25 hepatitis hepatitis NN cord-005453-4057qib7 3771 26 , , , cord-005453-4057qib7 3771 27 1 1 CD cord-005453-4057qib7 3771 28 septic septic JJ cord-005453-4057qib7 3771 29 shock shock NN cord-005453-4057qib7 3771 30 ) ) -RRB- cord-005453-4057qib7 3771 31 and and CC cord-005453-4057qib7 3771 32 6 6 CD cord-005453-4057qib7 3771 33 because because IN cord-005453-4057qib7 3771 34 of of IN cord-005453-4057qib7 3771 35 atrial atrial JJ cord-005453-4057qib7 3771 36 fibrillation fibrillation NN cord-005453-4057qib7 3771 37 or or CC cord-005453-4057qib7 3771 38 fibrilloflutter fibrilloflutter NN cord-005453-4057qib7 3771 39 . . . cord-005453-4057qib7 3772 1 Median median JJ cord-005453-4057qib7 3772 2 time time NN cord-005453-4057qib7 3772 3 from from IN cord-005453-4057qib7 3772 4 SCT SCT NNP cord-005453-4057qib7 3772 5 to to IN cord-005453-4057qib7 3772 6 first first JJ cord-005453-4057qib7 3772 7 day day NN cord-005453-4057qib7 3772 8 of of IN cord-005453-4057qib7 3772 9 G G NNP cord-005453-4057qib7 3772 10 - - HYPH cord-005453-4057qib7 3772 11 CSF CSF NNP cord-005453-4057qib7 3772 12 was be VBD cord-005453-4057qib7 3772 13 5 5 CD cord-005453-4057qib7 3772 14 days day NNS cord-005453-4057qib7 3772 15 ( ( -LRB- cord-005453-4057qib7 3772 16 5 5 CD cord-005453-4057qib7 3772 17 - - SYM cord-005453-4057qib7 3772 18 7 7 CD cord-005453-4057qib7 3772 19 ) ) -RRB- cord-005453-4057qib7 3772 20 and and CC cord-005453-4057qib7 3772 21 median median JJ cord-005453-4057qib7 3772 22 time time NN cord-005453-4057qib7 3772 23 on on IN cord-005453-4057qib7 3772 24 G G NNP cord-005453-4057qib7 3772 25 - - HYPH cord-005453-4057qib7 3772 26 CSF CSF NNP cord-005453-4057qib7 3772 27 treatment treatment NN cord-005453-4057qib7 3772 28 was be VBD cord-005453-4057qib7 3772 29 5 5 CD cord-005453-4057qib7 3772 30 days day NNS cord-005453-4057qib7 3772 31 ( ( -LRB- cord-005453-4057qib7 3772 32 4 4 CD cord-005453-4057qib7 3772 33 - - SYM cord-005453-4057qib7 3772 34 7 7 CD cord-005453-4057qib7 3772 35 ) ) -RRB- cord-005453-4057qib7 3772 36 . . . cord-005453-4057qib7 3773 1 Patients patient NNS cord-005453-4057qib7 3773 2 who who WP cord-005453-4057qib7 3773 3 received receive VBD cord-005453-4057qib7 3773 4 G G NNP cord-005453-4057qib7 3773 5 - - HYPH cord-005453-4057qib7 3773 6 CSF CSF NNP cord-005453-4057qib7 3773 7 showed show VBD cord-005453-4057qib7 3773 8 a a DT cord-005453-4057qib7 3773 9 short short JJ cord-005453-4057qib7 3773 10 time time NN cord-005453-4057qib7 3773 11 to to IN cord-005453-4057qib7 3773 12 neutrophil neutrophil NN cord-005453-4057qib7 3773 13 engraftment engraftment NN cord-005453-4057qib7 3773 14 ( ( -LRB- cord-005453-4057qib7 3773 15 ≥0.5x10 ≥0.5x10 NNP cord-005453-4057qib7 3773 16 6 6 CD cord-005453-4057qib7 3773 17 /L /L . cord-005453-4057qib7 3773 18 ) ) -RRB- cord-005453-4057qib7 3773 19 , , , cord-005453-4057qib7 3773 20 10 10 CD cord-005453-4057qib7 3773 21 days day NNS cord-005453-4057qib7 3773 22 vs. vs. IN cord-005453-4057qib7 3773 23 13 13 CD cord-005453-4057qib7 3773 24 days day NNS cord-005453-4057qib7 3773 25 , , , cord-005453-4057qib7 3773 26 p p NN cord-005453-4057qib7 3773 27 < < XX cord-005453-4057qib7 3773 28 0.001 0.001 CD cord-005453-4057qib7 3773 29 but but CC cord-005453-4057qib7 3773 30 longer long JJR cord-005453-4057qib7 3773 31 duration duration NN cord-005453-4057qib7 3773 32 of of IN cord-005453-4057qib7 3773 33 hospitalization hospitalization NN cord-005453-4057qib7 3773 34 , , , cord-005453-4057qib7 3773 35 18 18 CD cord-005453-4057qib7 3773 36 days day NNS cord-005453-4057qib7 3773 37 vs. vs. IN cord-005453-4057qib7 3773 38 15 15 CD cord-005453-4057qib7 3773 39 days day NNS cord-005453-4057qib7 3773 40 , , , cord-005453-4057qib7 3773 41 p p NN cord-005453-4057qib7 3773 42 = = SYM cord-005453-4057qib7 3773 43 0.050 0.050 CD cord-005453-4057qib7 3773 44 . . . cord-005453-4057qib7 3774 1 Non non JJ cord-005453-4057qib7 3774 2 - - JJ cord-005453-4057qib7 3774 3 relapse relapse JJ cord-005453-4057qib7 3774 4 mortality mortality NN cord-005453-4057qib7 3774 5 at at IN cord-005453-4057qib7 3774 6 day day NN cord-005453-4057qib7 3774 7 +30 +30 CD cord-005453-4057qib7 3774 8 , , , cord-005453-4057qib7 3774 9 +100 +100 NNP cord-005453-4057qib7 3774 10 and and CC cord-005453-4057qib7 3774 11 +180 +180 NNP cord-005453-4057qib7 3774 12 was be VBD cord-005453-4057qib7 3774 13 0 0 CD cord-005453-4057qib7 3774 14 % % NN cord-005453-4057qib7 3774 15 . . . cord-005453-4057qib7 3775 1 ES ES NNP cord-005453-4057qib7 3775 2 was be VBD cord-005453-4057qib7 3775 3 diagnosed diagnose VBN cord-005453-4057qib7 3775 4 in in IN cord-005453-4057qib7 3775 5 4 4 CD cord-005453-4057qib7 3775 6 ( ( -LRB- cord-005453-4057qib7 3775 7 6.2 6.2 CD cord-005453-4057qib7 3775 8 % % NN cord-005453-4057qib7 3775 9 ) ) -RRB- cord-005453-4057qib7 3775 10 patients patient NNS cord-005453-4057qib7 3775 11 , , , cord-005453-4057qib7 3775 12 1 1 CD cord-005453-4057qib7 3775 13 amyloidosis amyloidosis NN cord-005453-4057qib7 3775 14 , , , cord-005453-4057qib7 3775 15 2 2 CD cord-005453-4057qib7 3775 16 multiple multiple JJ cord-005453-4057qib7 3775 17 myeloma myeloma NN cord-005453-4057qib7 3775 18 and and CC cord-005453-4057qib7 3775 19 1 1 CD cord-005453-4057qib7 3775 20 plasmablastic plasmablastic JJ cord-005453-4057qib7 3775 21 lymphoma lymphoma NN cord-005453-4057qib7 3775 22 . . . cord-005453-4057qib7 3776 1 There there EX cord-005453-4057qib7 3776 2 was be VBD cord-005453-4057qib7 3776 3 not not RB cord-005453-4057qib7 3776 4 statistical statistical JJ cord-005453-4057qib7 3776 5 difference difference NN cord-005453-4057qib7 3776 6 in in IN cord-005453-4057qib7 3776 7 the the DT cord-005453-4057qib7 3776 8 incidence incidence NN cord-005453-4057qib7 3776 9 of of IN cord-005453-4057qib7 3776 10 ES es NN cord-005453-4057qib7 3776 11 between between IN cord-005453-4057qib7 3776 12 patients patient NNS cord-005453-4057qib7 3776 13 who who WP cord-005453-4057qib7 3776 14 received receive VBD cord-005453-4057qib7 3776 15 G G NNP cord-005453-4057qib7 3776 16 - - HYPH cord-005453-4057qib7 3776 17 CSF CSF NNP cord-005453-4057qib7 3776 18 ( ( -LRB- cord-005453-4057qib7 3776 19 9.1 9.1 CD cord-005453-4057qib7 3776 20 % % NN cord-005453-4057qib7 3776 21 ) ) -RRB- cord-005453-4057qib7 3776 22 and and CC cord-005453-4057qib7 3776 23 patients patient NNS cord-005453-4057qib7 3776 24 who who WP cord-005453-4057qib7 3776 25 did do VBD cord-005453-4057qib7 3776 26 not not RB cord-005453-4057qib7 3776 27 ( ( -LRB- cord-005453-4057qib7 3776 28 5.6 5.6 CD cord-005453-4057qib7 3776 29 % % NN cord-005453-4057qib7 3776 30 ) ) -RRB- cord-005453-4057qib7 3776 31 , , , cord-005453-4057qib7 3776 32 p=0.533 p=0.533 NNP cord-005453-4057qib7 3776 33 . . . cord-005453-4057qib7 3777 1 Analyzed analyze VBN cord-005453-4057qib7 3777 2 by by IN cord-005453-4057qib7 3777 3 disease disease NN cord-005453-4057qib7 3777 4 , , , cord-005453-4057qib7 3777 5 ES ES NNP cord-005453-4057qib7 3777 6 appeared appear VBD cord-005453-4057qib7 3777 7 in in IN cord-005453-4057qib7 3777 8 1 1 CD cord-005453-4057qib7 3777 9 of of IN cord-005453-4057qib7 3777 10 6 6 CD cord-005453-4057qib7 3777 11 patients patient NNS cord-005453-4057qib7 3777 12 who who WP cord-005453-4057qib7 3777 13 received receive VBD cord-005453-4057qib7 3777 14 G G NNP cord-005453-4057qib7 3777 15 - - HYPH cord-005453-4057qib7 3777 16 CSF CSF NNP cord-005453-4057qib7 3777 17 in in IN cord-005453-4057qib7 3777 18 the the DT cord-005453-4057qib7 3777 19 lymphoma lymphoma NN cord-005453-4057qib7 3777 20 group group NN cord-005453-4057qib7 3777 21 ( ( -LRB- cord-005453-4057qib7 3777 22 16.6 16.6 CD cord-005453-4057qib7 3777 23 % % NN cord-005453-4057qib7 3777 24 ) ) -RRB- cord-005453-4057qib7 3777 25 but but CC cord-005453-4057qib7 3777 26 none none NN cord-005453-4057qib7 3777 27 of of IN cord-005453-4057qib7 3777 28 the the DT cord-005453-4057qib7 3777 29 7 7 CD cord-005453-4057qib7 3777 30 patients patient NNS cord-005453-4057qib7 3777 31 with with IN cord-005453-4057qib7 3777 32 MG MG NNP cord-005453-4057qib7 3777 33 that that WDT cord-005453-4057qib7 3777 34 received receive VBD cord-005453-4057qib7 3777 35 G G NNP cord-005453-4057qib7 3777 36 - - HYPH cord-005453-4057qib7 3777 37 CSF CSF NNP cord-005453-4057qib7 3777 38 developed develop VBD cord-005453-4057qib7 3777 39 it -PRON- PRP cord-005453-4057qib7 3777 40 . . . cord-005453-4057qib7 3778 1 We -PRON- PRP cord-005453-4057qib7 3778 2 did do VBD cord-005453-4057qib7 3778 3 not not RB cord-005453-4057qib7 3778 4 find find VB cord-005453-4057qib7 3778 5 statistical statistical JJ cord-005453-4057qib7 3778 6 differences difference NNS cord-005453-4057qib7 3778 7 between between IN cord-005453-4057qib7 3778 8 patients patient NNS cord-005453-4057qib7 3778 9 who who WP cord-005453-4057qib7 3778 10 developed develop VBD cord-005453-4057qib7 3778 11 ES ES NNP cord-005453-4057qib7 3778 12 and and CC cord-005453-4057qib7 3778 13 those those DT cord-005453-4057qib7 3778 14 who who WP cord-005453-4057qib7 3778 15 did do VBD cord-005453-4057qib7 3778 16 not not RB cord-005453-4057qib7 3778 17 in in IN cord-005453-4057qib7 3778 18 age age NN cord-005453-4057qib7 3778 19 ( ( -LRB- cord-005453-4057qib7 3778 20 49 49 CD cord-005453-4057qib7 3778 21 years year NNS cord-005453-4057qib7 3778 22 vs. vs. IN cord-005453-4057qib7 3778 23 56 56 CD cord-005453-4057qib7 3778 24 years year NNS cord-005453-4057qib7 3778 25 , , , cord-005453-4057qib7 3778 26 p=0 p=0 NNP cord-005453-4057qib7 3778 27 . . . cord-005453-4057qib7 3779 1 314 314 LS cord-005453-4057qib7 3779 2 ) ) -RRB- cord-005453-4057qib7 3779 3 , , , cord-005453-4057qib7 3779 4 length length NN cord-005453-4057qib7 3779 5 of of IN cord-005453-4057qib7 3779 6 hospitalization hospitalization NN cord-005453-4057qib7 3779 7 ( ( -LRB- cord-005453-4057qib7 3779 8 19 19 CD cord-005453-4057qib7 3779 9 days day NNS cord-005453-4057qib7 3779 10 vs. vs. IN cord-005453-4057qib7 3779 11 15 15 CD cord-005453-4057qib7 3779 12 days day NNS cord-005453-4057qib7 3779 13 , , , cord-005453-4057qib7 3779 14 p=0.185 p=0.185 LS cord-005453-4057qib7 3779 15 ) ) -RRB- cord-005453-4057qib7 3779 16 and and CC cord-005453-4057qib7 3779 17 the the DT cord-005453-4057qib7 3779 18 number number NN cord-005453-4057qib7 3779 19 of of IN cord-005453-4057qib7 3779 20 CD34 CD34 NNP cord-005453-4057qib7 3780 1 x x SYM cord-005453-4057qib7 3780 2 10 10 CD cord-005453-4057qib7 3780 3 6 6 CD cord-005453-4057qib7 3780 4 /Kg /kg NN cord-005453-4057qib7 3780 5 cells cell NNS cord-005453-4057qib7 3780 6 infused infuse VBN cord-005453-4057qib7 3780 7 ( ( -LRB- cord-005453-4057qib7 3780 8 3.65 3.65 CD cord-005453-4057qib7 3780 9 vs. vs. IN cord-005453-4057qib7 3780 10 4.62 4.62 CD cord-005453-4057qib7 3780 11 , , , cord-005453-4057qib7 3780 12 p=0.408 p=0.408 NN cord-005453-4057qib7 3780 13 ) ) -RRB- cord-005453-4057qib7 3780 14 . . . cord-005453-4057qib7 3781 1 Conclusions conclusion NNS cord-005453-4057qib7 3781 2 : : : cord-005453-4057qib7 3782 1 The the DT cord-005453-4057qib7 3782 2 use use NN cord-005453-4057qib7 3782 3 of of IN cord-005453-4057qib7 3782 4 G G NNP cord-005453-4057qib7 3782 5 - - HYPH cord-005453-4057qib7 3782 6 CSF CSF NNP cord-005453-4057qib7 3782 7 in in IN cord-005453-4057qib7 3782 8 selected select VBN cord-005453-4057qib7 3782 9 patients patient NNS cord-005453-4057qib7 3782 10 is be VBZ cord-005453-4057qib7 3782 11 associated associate VBN cord-005453-4057qib7 3782 12 with with IN cord-005453-4057qib7 3782 13 low low JJ cord-005453-4057qib7 3782 14 incidence incidence NN cord-005453-4057qib7 3782 15 of of IN cord-005453-4057qib7 3782 16 ES ES NNP cord-005453-4057qib7 3782 17 . . . cord-005453-4057qib7 3783 1 Our -PRON- PRP$ cord-005453-4057qib7 3783 2 study study NN cord-005453-4057qib7 3783 3 confirms confirm VBZ cord-005453-4057qib7 3783 4 that that IN cord-005453-4057qib7 3783 5 the the DT cord-005453-4057qib7 3783 6 use use NN cord-005453-4057qib7 3783 7 of of IN cord-005453-4057qib7 3783 8 G G NNP cord-005453-4057qib7 3783 9 - - HYPH cord-005453-4057qib7 3783 10 CSF CSF NNP cord-005453-4057qib7 3783 11 accelerates accelerate VBZ cord-005453-4057qib7 3783 12 neutrophil neutrophil NN cord-005453-4057qib7 3783 13 recovery recovery NN cord-005453-4057qib7 3783 14 but but CC cord-005453-4057qib7 3783 15 it -PRON- PRP cord-005453-4057qib7 3783 16 is be VBZ cord-005453-4057qib7 3783 17 unclear unclear JJ cord-005453-4057qib7 3783 18 if if IN cord-005453-4057qib7 3783 19 it -PRON- PRP cord-005453-4057qib7 3783 20 can can MD cord-005453-4057qib7 3783 21 increase increase VB cord-005453-4057qib7 3783 22 the the DT cord-005453-4057qib7 3783 23 incidence incidence NN cord-005453-4057qib7 3783 24 of of IN cord-005453-4057qib7 3783 25 ES ES NNP cord-005453-4057qib7 3783 26 , , , cord-005453-4057qib7 3783 27 especially especially RB cord-005453-4057qib7 3783 28 in in IN cord-005453-4057qib7 3783 29 patients patient NNS cord-005453-4057qib7 3783 30 with with IN cord-005453-4057qib7 3783 31 lymphoma lymphoma NN cord-005453-4057qib7 3783 32 . . . cord-005453-4057qib7 3784 1 [ [ -LRB- cord-005453-4057qib7 3784 2 [ [ -LRB- cord-005453-4057qib7 3784 3 P180 P180 NNP cord-005453-4057qib7 3784 4 Image image NN cord-005453-4057qib7 3784 5 ] ] -RRB- cord-005453-4057qib7 3784 6 1 1 CD cord-005453-4057qib7 3784 7 . . . cord-005453-4057qib7 3785 1 Background background NN cord-005453-4057qib7 3785 2 : : : cord-005453-4057qib7 3786 1 Graft graft NN cord-005453-4057qib7 3786 2 failure failure NN cord-005453-4057qib7 3786 3 is be VBZ cord-005453-4057qib7 3786 4 one one CD cord-005453-4057qib7 3786 5 of of IN cord-005453-4057qib7 3786 6 the the DT cord-005453-4057qib7 3786 7 TOP-3 TOP-3 NNP cord-005453-4057qib7 3786 8 problems problem NNS cord-005453-4057qib7 3786 9 of of IN cord-005453-4057qib7 3786 10 allo allo NN cord-005453-4057qib7 3786 11 - - HYPH cord-005453-4057qib7 3786 12 HSCT HSCT NNP cord-005453-4057qib7 3786 13 ( ( -LRB- cord-005453-4057qib7 3786 14 after after IN cord-005453-4057qib7 3786 15 GVHD GVHD NNP cord-005453-4057qib7 3786 16 and and CC cord-005453-4057qib7 3786 17 relapse relapse NN cord-005453-4057qib7 3786 18 ) ) -RRB- cord-005453-4057qib7 3786 19 . . . cord-005453-4057qib7 3787 1 The the DT cord-005453-4057qib7 3787 2 problem problem NN cord-005453-4057qib7 3787 3 of of IN cord-005453-4057qib7 3787 4 graft graft NN cord-005453-4057qib7 3787 5 failure failure NN cord-005453-4057qib7 3787 6 becomes become VBZ cord-005453-4057qib7 3787 7 more more RBR cord-005453-4057qib7 3787 8 significant significant JJ cord-005453-4057qib7 3787 9 due due IN cord-005453-4057qib7 3787 10 to to IN cord-005453-4057qib7 3787 11 increasing increase VBG cord-005453-4057qib7 3787 12 number number NN cord-005453-4057qib7 3787 13 of of IN cord-005453-4057qib7 3787 14 allo allo NN cord-005453-4057qib7 3787 15 - - HYPH cord-005453-4057qib7 3787 16 HSCT HSCT NNP cord-005453-4057qib7 3787 17 with with IN cord-005453-4057qib7 3787 18 RIC RIC NNP cord-005453-4057qib7 3787 19 conditioning conditioning NN cord-005453-4057qib7 3787 20 regimen regimen NN cord-005453-4057qib7 3787 21 from from IN cord-005453-4057qib7 3787 22 haploidentical haploidentical JJ cord-005453-4057qib7 3787 23 and and CC cord-005453-4057qib7 3787 24 HLA HLA NNP cord-005453-4057qib7 3787 25 - - HYPH cord-005453-4057qib7 3787 26 mismatched mismatch VBN cord-005453-4057qib7 3787 27 unrelated unrelated JJ cord-005453-4057qib7 3787 28 donors donor NNS cord-005453-4057qib7 3787 29 . . . cord-005453-4057qib7 3788 1 Role role NN cord-005453-4057qib7 3788 2 of of IN cord-005453-4057qib7 3788 3 T T NNP cord-005453-4057qib7 3788 4 cells cell NNS cord-005453-4057qib7 3788 5 in in IN cord-005453-4057qib7 3788 6 graft graft NN cord-005453-4057qib7 3788 7 failure failure NN cord-005453-4057qib7 3788 8 is be VBZ cord-005453-4057qib7 3788 9 well well RB cord-005453-4057qib7 3788 10 known known JJ cord-005453-4057qib7 3788 11 . . . cord-005453-4057qib7 3789 1 Here here RB cord-005453-4057qib7 3789 2 we -PRON- PRP cord-005453-4057qib7 3789 3 report report VBP cord-005453-4057qib7 3789 4 an an DT cord-005453-4057qib7 3789 5 impact impact NN cord-005453-4057qib7 3789 6 of of IN cord-005453-4057qib7 3789 7 T t NN cord-005453-4057qib7 3789 8 - - HYPH cord-005453-4057qib7 3789 9 memory memory NN cord-005453-4057qib7 3789 10 cell cell NN cord-005453-4057qib7 3789 11 subsets subset NNS cord-005453-4057qib7 3789 12 count count VBP cord-005453-4057qib7 3789 13 before before IN cord-005453-4057qib7 3789 14 Antithymocyte Antithymocyte NNP cord-005453-4057qib7 3789 15 globulin globulin NN cord-005453-4057qib7 3789 16 ( ( -LRB- cord-005453-4057qib7 3789 17 ATG ATG NNP cord-005453-4057qib7 3789 18 ) ) -RRB- cord-005453-4057qib7 3789 19 administration administration NN cord-005453-4057qib7 3789 20 on on IN cord-005453-4057qib7 3789 21 primary primary JJ cord-005453-4057qib7 3789 22 graft graft NN cord-005453-4057qib7 3789 23 failure failure NN cord-005453-4057qib7 3789 24 after after IN cord-005453-4057qib7 3789 25 allo allo NN cord-005453-4057qib7 3789 26 - - HYPH cord-005453-4057qib7 3789 27 HSCT HSCT NNP cord-005453-4057qib7 3789 28 . . . cord-005453-4057qib7 3790 1 Methods method NNS cord-005453-4057qib7 3790 2 : : : cord-005453-4057qib7 3791 1 Sixteen sixteen CD cord-005453-4057qib7 3791 2 patients patient NNS cord-005453-4057qib7 3791 3 with with IN cord-005453-4057qib7 3791 4 acute acute JJ cord-005453-4057qib7 3791 5 leukemia leukemia NN cord-005453-4057qib7 3791 6 transplanted transplant VBN cord-005453-4057qib7 3791 7 in in IN cord-005453-4057qib7 3791 8 National National NNP cord-005453-4057qib7 3791 9 Research Research NNP cord-005453-4057qib7 3791 10 Center Center NNP cord-005453-4057qib7 3791 11 for for IN cord-005453-4057qib7 3791 12 Hematology Hematology NNP cord-005453-4057qib7 3791 13 were be VBD cord-005453-4057qib7 3791 14 included include VBN cord-005453-4057qib7 3791 15 on on IN cord-005453-4057qib7 3791 16 this this DT cord-005453-4057qib7 3791 17 prospective prospective JJ cord-005453-4057qib7 3791 18 study study NN cord-005453-4057qib7 3791 19 . . . cord-005453-4057qib7 3792 1 All all DT cord-005453-4057qib7 3792 2 patients patient NNS cord-005453-4057qib7 3792 3 received receive VBD cord-005453-4057qib7 3792 4 horse horse NN cord-005453-4057qib7 3792 5 ATG ATG NNP cord-005453-4057qib7 3792 6 at at IN cord-005453-4057qib7 3792 7 dose dose NN cord-005453-4057qib7 3792 8 10 10 CD cord-005453-4057qib7 3792 9 mg mg NNP cord-005453-4057qib7 3792 10 / / SYM cord-005453-4057qib7 3792 11 kg kg NNP cord-005453-4057qib7 3792 12 / / SYM cord-005453-4057qib7 3792 13 day day NN cord-005453-4057qib7 3792 14 from from IN cord-005453-4057qib7 3792 15 day day NN cord-005453-4057qib7 3792 16 -4 -4 ADD cord-005453-4057qib7 3792 17 to to IN cord-005453-4057qib7 3792 18 -1 -1 NN cord-005453-4057qib7 3792 19 before before IN cord-005453-4057qib7 3792 20 allo allo NN cord-005453-4057qib7 3792 21 - - HYPH cord-005453-4057qib7 3792 22 HSCT HSCT NNP cord-005453-4057qib7 3792 23 as as IN cord-005453-4057qib7 3792 24 GVHD GVHD NNP cord-005453-4057qib7 3792 25 prophylaxis prophylaxis NN cord-005453-4057qib7 3792 26 and and CC cord-005453-4057qib7 3792 27 were be VBD cord-005453-4057qib7 3792 28 balanced balance VBN cord-005453-4057qib7 3792 29 by by IN cord-005453-4057qib7 3792 30 other other JJ cord-005453-4057qib7 3792 31 factors factor NNS cord-005453-4057qib7 3792 32 that that WDT cord-005453-4057qib7 3792 33 could could MD cord-005453-4057qib7 3792 34 affect affect VB cord-005453-4057qib7 3792 35 engraftment engraftment NN cord-005453-4057qib7 3792 36 . . . cord-005453-4057qib7 3793 1 Detailed detailed JJ cord-005453-4057qib7 3793 2 patients patient NNS cord-005453-4057qib7 3793 3 characteristics characteristic NNS cord-005453-4057qib7 3793 4 are be VBP cord-005453-4057qib7 3793 5 listed list VBN cord-005453-4057qib7 3793 6 in in IN cord-005453-4057qib7 3793 7 Table Table NNP cord-005453-4057qib7 3793 8 1 1 CD cord-005453-4057qib7 3793 9 . . . cord-005453-4057qib7 3794 1 Peripheral peripheral JJ cord-005453-4057qib7 3794 2 blood blood NN cord-005453-4057qib7 3794 3 samples sample NNS cord-005453-4057qib7 3794 4 were be VBD cord-005453-4057qib7 3794 5 collected collect VBN cord-005453-4057qib7 3794 6 on on IN cord-005453-4057qib7 3794 7 day day NN cord-005453-4057qib7 3794 8 -4 -4 NFP cord-005453-4057qib7 3794 9 before before IN cord-005453-4057qib7 3794 10 allo allo NN cord-005453-4057qib7 3794 11 - - HYPH cord-005453-4057qib7 3794 12 HSCT HSCT NNP cord-005453-4057qib7 3794 13 ( ( -LRB- cord-005453-4057qib7 3794 14 before before IN cord-005453-4057qib7 3794 15 ATG ATG NNP cord-005453-4057qib7 3794 16 injection injection NN cord-005453-4057qib7 3794 17 ) ) -RRB- cord-005453-4057qib7 3794 18 in in IN cord-005453-4057qib7 3794 19 EDTA EDTA NNP cord-005453-4057qib7 3794 20 - - HYPH cord-005453-4057qib7 3794 21 tubes tube NNS cord-005453-4057qib7 3794 22 . . . cord-005453-4057qib7 3795 1 Flow flow NN cord-005453-4057qib7 3795 2 cytometry cytometry NN cord-005453-4057qib7 3795 3 analysis analysis NN cord-005453-4057qib7 3795 4 was be VBD cord-005453-4057qib7 3795 5 performed perform VBN cord-005453-4057qib7 3795 6 on on IN cord-005453-4057qib7 3795 7 BD BD NNP cord-005453-4057qib7 3795 8 FACS FACS NNP cord-005453-4057qib7 3795 9 Canto Canto NNP cord-005453-4057qib7 3795 10 II II NNP cord-005453-4057qib7 3796 1 ( ( -LRB- cord-005453-4057qib7 3796 2 Becton Becton NNP cord-005453-4057qib7 3796 3 Dickinson Dickinson NNP cord-005453-4057qib7 3796 4 , , , cord-005453-4057qib7 3796 5 USA USA NNP cord-005453-4057qib7 3796 6 ) ) -RRB- cord-005453-4057qib7 3796 7 to to TO cord-005453-4057qib7 3796 8 define define VB cord-005453-4057qib7 3796 9 T t NN cord-005453-4057qib7 3796 10 - - HYPH cord-005453-4057qib7 3796 11 memory memory NN cord-005453-4057qib7 3796 12 subsets subset NNS cord-005453-4057qib7 3796 13 : : : cord-005453-4057qib7 3796 14 T t NN cord-005453-4057qib7 3796 15 - - HYPH cord-005453-4057qib7 3796 16 naive naive JJ cord-005453-4057qib7 3796 17 and and CC cord-005453-4057qib7 3796 18 T t NN cord-005453-4057qib7 3796 19 - - HYPH cord-005453-4057qib7 3796 20 stem stem NN cord-005453-4057qib7 3796 21 cell cell NN cord-005453-4057qib7 3796 22 memory memory NN cord-005453-4057qib7 3796 23 ( ( -LRB- cord-005453-4057qib7 3796 24 Tnv+scm Tnv+scm NNP cord-005453-4057qib7 3796 25 ) ) -RRB- cord-005453-4057qib7 3797 1 -CD45R0-CCR7+CD28 -cd45r0-ccr7+cd28 LS cord-005453-4057qib7 3797 2 + + CC cord-005453-4057qib7 3797 3 ; ; : cord-005453-4057qib7 3797 4 T t JJ cord-005453-4057qib7 3797 5 - - HYPH cord-005453-4057qib7 3797 6 central central JJ cord-005453-4057qib7 3797 7 memory memory NN cord-005453-4057qib7 3797 8 ( ( -LRB- cord-005453-4057qib7 3797 9 Tcm Tcm NNP cord-005453-4057qib7 3797 10 ) ) -RRB- cord-005453-4057qib7 3797 11 -CD45R0+CCR7+CD28 -CD45R0+CCR7+CD28 . cord-005453-4057qib7 3798 1 + + CC cord-005453-4057qib7 3798 2 ; ; : cord-005453-4057qib7 3798 3 T t JJ cord-005453-4057qib7 3798 4 - - HYPH cord-005453-4057qib7 3798 5 transitional transitional JJ cord-005453-4057qib7 3798 6 memory memory NN cord-005453-4057qib7 3798 7 ( ( -LRB- cord-005453-4057qib7 3798 8 Ttm Ttm NNP cord-005453-4057qib7 3798 9 ) ) -RRB- cord-005453-4057qib7 3798 10 -CD45R0+CCR7-CD28 -CD45R0+CCR7-CD28 . cord-005453-4057qib7 3799 1 + + CC cord-005453-4057qib7 3799 2 ; ; : cord-005453-4057qib7 3799 3 T t NN cord-005453-4057qib7 3799 4 - - HYPH cord-005453-4057qib7 3799 5 effector effector NN cord-005453-4057qib7 3799 6 memory memory NN cord-005453-4057qib7 3799 7 ( ( -LRB- cord-005453-4057qib7 3799 8 Tem Tem NNP cord-005453-4057qib7 3799 9 ) ) -RRB- cord-005453-4057qib7 3799 10 -CD45R0+CCR7-CD28- -cd45r0+ccr7-cd28- NN cord-005453-4057qib7 3799 11 ; ; : cord-005453-4057qib7 3799 12 T t NN cord-005453-4057qib7 3799 13 - - HYPH cord-005453-4057qib7 3799 14 terminal terminal NN cord-005453-4057qib7 3799 15 effector effector NN cord-005453-4057qib7 3799 16 ( ( -LRB- cord-005453-4057qib7 3799 17 Tte Tte NNP cord-005453-4057qib7 3799 18 ) ) -RRB- cord-005453-4057qib7 3799 19 -CD45R0-CCR7-CD28- -CD45R0-CCR7-CD28- NNP cord-005453-4057qib7 3799 20 , , , cord-005453-4057qib7 3799 21 among among IN cord-005453-4057qib7 3799 22 CD4 CD4 NNP cord-005453-4057qib7 3799 23 + + CC cord-005453-4057qib7 3799 24 and and CC cord-005453-4057qib7 3799 25 CD8 CD8 NNP cord-005453-4057qib7 3799 26 + + CC cord-005453-4057qib7 3799 27 T T NNP cord-005453-4057qib7 3799 28 - - HYPH cord-005453-4057qib7 3799 29 cells cell NNS cord-005453-4057qib7 3799 30 . . . cord-005453-4057qib7 3800 1 Sysmex Sysmex NNP cord-005453-4057qib7 3800 2 XE-2100 XE-2100 NNS cord-005453-4057qib7 3800 3 was be VBD cord-005453-4057qib7 3800 4 used use VBN cord-005453-4057qib7 3800 5 to to TO cord-005453-4057qib7 3800 6 calculate calculate VB cord-005453-4057qib7 3800 7 absolute absolute JJ cord-005453-4057qib7 3800 8 count count NN cord-005453-4057qib7 3800 9 of of IN cord-005453-4057qib7 3800 10 different different JJ cord-005453-4057qib7 3800 11 T t NN cord-005453-4057qib7 3800 12 - - HYPH cord-005453-4057qib7 3800 13 cell cell NN cord-005453-4057qib7 3800 14 subsets subset NNS cord-005453-4057qib7 3800 15 . . . cord-005453-4057qib7 3801 1 Mann Mann NNP cord-005453-4057qib7 3801 2 - - HYPH cord-005453-4057qib7 3801 3 Whitney Whitney NNP cord-005453-4057qib7 3801 4 U U NNP cord-005453-4057qib7 3801 5 test test NN cord-005453-4057qib7 3801 6 was be VBD cord-005453-4057qib7 3801 7 used use VBN cord-005453-4057qib7 3801 8 for for IN cord-005453-4057qib7 3801 9 nonparametric nonparametric JJ cord-005453-4057qib7 3801 10 data data NN cord-005453-4057qib7 3801 11 analysis analysis NN cord-005453-4057qib7 3801 12 between between IN cord-005453-4057qib7 3801 13 two two CD cord-005453-4057qib7 3801 14 groups group NNS cord-005453-4057qib7 3801 15 . . . cord-005453-4057qib7 3802 1 Fisher Fisher NNP cord-005453-4057qib7 3802 2 's 's POS cord-005453-4057qib7 3802 3 exact exact JJ cord-005453-4057qib7 3802 4 test test NN cord-005453-4057qib7 3802 5 was be VBD cord-005453-4057qib7 3802 6 used use VBN cord-005453-4057qib7 3802 7 for for IN cord-005453-4057qib7 3802 8 2x2 2x2 CD cord-005453-4057qib7 3802 9 tables table NNS cord-005453-4057qib7 3802 10 . . . cord-005453-4057qib7 3803 1 P p NN cord-005453-4057qib7 3803 2 - - HYPH cord-005453-4057qib7 3803 3 value value NN cord-005453-4057qib7 3803 4 less less JJR cord-005453-4057qib7 3803 5 than than IN cord-005453-4057qib7 3803 6 0.05 0.05 CD cord-005453-4057qib7 3803 7 was be VBD cord-005453-4057qib7 3803 8 considered consider VBN cord-005453-4057qib7 3803 9 statistically statistically RB cord-005453-4057qib7 3803 10 significant significant JJ cord-005453-4057qib7 3803 11 . . . cord-005453-4057qib7 3804 1 Results result NNS cord-005453-4057qib7 3804 2 : : : cord-005453-4057qib7 3805 1 An an DT cord-005453-4057qib7 3805 2 influence influence NN cord-005453-4057qib7 3805 3 of of IN cord-005453-4057qib7 3805 4 T t NN cord-005453-4057qib7 3805 5 - - HYPH cord-005453-4057qib7 3805 6 memory memory NN cord-005453-4057qib7 3805 7 cell cell NN cord-005453-4057qib7 3805 8 subsets subset NNS cord-005453-4057qib7 3805 9 count count VBP cord-005453-4057qib7 3805 10 before before IN cord-005453-4057qib7 3805 11 ATG ATG NNP cord-005453-4057qib7 3805 12 administration administration NN cord-005453-4057qib7 3805 13 on on IN cord-005453-4057qib7 3805 14 primary primary JJ cord-005453-4057qib7 3805 15 graft graft NN cord-005453-4057qib7 3805 16 failure failure NN cord-005453-4057qib7 3805 17 is be VBZ cord-005453-4057qib7 3805 18 shown show VBN cord-005453-4057qib7 3805 19 in in IN cord-005453-4057qib7 3805 20 Figure figure NN cord-005453-4057qib7 3805 21 1 1 CD cord-005453-4057qib7 3805 22 . . . cord-005453-4057qib7 3806 1 According accord VBG cord-005453-4057qib7 3806 2 to to IN cord-005453-4057qib7 3806 3 our -PRON- PRP$ cord-005453-4057qib7 3806 4 data data NN cord-005453-4057qib7 3806 5 high high JJ cord-005453-4057qib7 3806 6 absolute absolute JJ cord-005453-4057qib7 3806 7 number number NN cord-005453-4057qib7 3806 8 of of IN cord-005453-4057qib7 3806 9 CD4+Ttm cd4+ttm NN cord-005453-4057qib7 3806 10 and and CC cord-005453-4057qib7 3806 11 CD4+Tte CD4+Tte NNP cord-005453-4057qib7 3806 12 is be VBZ cord-005453-4057qib7 3806 13 associated associate VBN cord-005453-4057qib7 3806 14 with with IN cord-005453-4057qib7 3806 15 primary primary JJ cord-005453-4057qib7 3806 16 graft graft NN cord-005453-4057qib7 3806 17 failure failure NN cord-005453-4057qib7 3806 18 . . . cord-005453-4057qib7 3807 1 Conclusions conclusion NNS cord-005453-4057qib7 3807 2 : : : cord-005453-4057qib7 3808 1 Based base VBN cord-005453-4057qib7 3808 2 on on IN cord-005453-4057qib7 3808 3 these these DT cord-005453-4057qib7 3808 4 findings finding NNS cord-005453-4057qib7 3808 5 high high JJ cord-005453-4057qib7 3808 6 absolute absolute JJ cord-005453-4057qib7 3808 7 number number NN cord-005453-4057qib7 3808 8 of of IN cord-005453-4057qib7 3808 9 CD4+Ttm cd4+ttm NN cord-005453-4057qib7 3808 10 and and CC cord-005453-4057qib7 3808 11 CD4+Tte CD4+Tte NNP cord-005453-4057qib7 3808 12 could could MD cord-005453-4057qib7 3808 13 be be VB cord-005453-4057qib7 3808 14 one one CD cord-005453-4057qib7 3808 15 of of IN cord-005453-4057qib7 3808 16 the the DT cord-005453-4057qib7 3808 17 prognostic prognostic JJ cord-005453-4057qib7 3808 18 factors factor NNS cord-005453-4057qib7 3808 19 of of IN cord-005453-4057qib7 3808 20 primary primary JJ cord-005453-4057qib7 3808 21 graft graft NN cord-005453-4057qib7 3808 22 failure failure NN cord-005453-4057qib7 3808 23 after after IN cord-005453-4057qib7 3808 24 allo allo NN cord-005453-4057qib7 3808 25 - - HYPH cord-005453-4057qib7 3808 26 HSCT HSCT NNP cord-005453-4057qib7 3808 27 . . . cord-005453-4057qib7 3809 1 Optimizing optimize VBG cord-005453-4057qib7 3809 2 ATG ATG NNP cord-005453-4057qib7 3809 3 dose dose NN cord-005453-4057qib7 3809 4 due due IN cord-005453-4057qib7 3809 5 to to IN cord-005453-4057qib7 3809 6 recipient recipient NN cord-005453-4057qib7 3810 1 absolute absolute NNP cord-005453-4057qib7 3810 2 T T NNP cord-005453-4057qib7 3810 3 - - HYPH cord-005453-4057qib7 3810 4 memory memory NN cord-005453-4057qib7 3810 5 cell cell NN cord-005453-4057qib7 3810 6 subsets subset NNS cord-005453-4057qib7 3810 7 count count VBP cord-005453-4057qib7 3810 8 before before IN cord-005453-4057qib7 3810 9 ATG ATG NNP cord-005453-4057qib7 3810 10 administering administer VBG cord-005453-4057qib7 3810 11 may may MD cord-005453-4057qib7 3810 12 prevent prevent VB cord-005453-4057qib7 3810 13 graft graft NN cord-005453-4057qib7 3810 14 failure failure NN cord-005453-4057qib7 3810 15 and and CC cord-005453-4057qib7 3810 16 improve improve VB cord-005453-4057qib7 3810 17 posttransplant posttransplant NN cord-005453-4057qib7 3810 18 results result NNS cord-005453-4057qib7 3810 19 . . . cord-005453-4057qib7 3811 1 Background background NN cord-005453-4057qib7 3811 2 : : : cord-005453-4057qib7 3812 1 Upper upper JJ cord-005453-4057qib7 3812 2 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 3812 3 graft graft NN cord-005453-4057qib7 3812 4 - - HYPH cord-005453-4057qib7 3812 5 versus versus IN cord-005453-4057qib7 3812 6 - - HYPH cord-005453-4057qib7 3812 7 host host NN cord-005453-4057qib7 3812 8 disease disease NN cord-005453-4057qib7 3812 9 ( ( -LRB- cord-005453-4057qib7 3812 10 GI GI NNP cord-005453-4057qib7 3812 11 GVHD GVHD NNP cord-005453-4057qib7 3812 12 ) ) -RRB- cord-005453-4057qib7 3812 13 has have VBZ cord-005453-4057qib7 3812 14 been be VBN cord-005453-4057qib7 3812 15 an an DT cord-005453-4057qib7 3812 16 increasingly increasingly RB cord-005453-4057qib7 3812 17 recognised recognise VBN cord-005453-4057qib7 3812 18 entity entity NN cord-005453-4057qib7 3812 19 following follow VBG cord-005453-4057qib7 3812 20 allogeneic allogeneic IN cord-005453-4057qib7 3812 21 stem stem NN cord-005453-4057qib7 3812 22 cell cell NN cord-005453-4057qib7 3812 23 transplantation transplantation NN cord-005453-4057qib7 3812 24 ( ( -LRB- cord-005453-4057qib7 3812 25 SCT SCT NNP cord-005453-4057qib7 3812 26 ) ) -RRB- cord-005453-4057qib7 3812 27 . . . cord-005453-4057qib7 3813 1 Budesonide Budesonide NNP cord-005453-4057qib7 3813 2 , , , cord-005453-4057qib7 3813 3 widely widely RB cord-005453-4057qib7 3813 4 used use VBN cord-005453-4057qib7 3813 5 in in IN cord-005453-4057qib7 3813 6 inflammatory inflammatory JJ cord-005453-4057qib7 3813 7 bowel bowel NN cord-005453-4057qib7 3813 8 conditions condition NNS cord-005453-4057qib7 3813 9 , , , cord-005453-4057qib7 3813 10 has have VBZ cord-005453-4057qib7 3813 11 also also RB cord-005453-4057qib7 3813 12 been be VBN cord-005453-4057qib7 3813 13 found find VBN cord-005453-4057qib7 3813 14 beneficial beneficial JJ cord-005453-4057qib7 3813 15 in in IN cord-005453-4057qib7 3813 16 GI GI NNP cord-005453-4057qib7 3813 17 GVHD GVHD NNP cord-005453-4057qib7 3813 18 . . . cord-005453-4057qib7 3814 1 The the DT cord-005453-4057qib7 3814 2 major major JJ cord-005453-4057qib7 3814 3 benefit benefit NN cord-005453-4057qib7 3814 4 of of IN cord-005453-4057qib7 3814 5 Budesonide Budesonide NNP cord-005453-4057qib7 3814 6 is be VBZ cord-005453-4057qib7 3814 7 attributable attributable JJ cord-005453-4057qib7 3814 8 to to IN cord-005453-4057qib7 3814 9 its -PRON- PRP$ cord-005453-4057qib7 3814 10 poor poor JJ cord-005453-4057qib7 3814 11 absorption absorption NN cord-005453-4057qib7 3814 12 and and CC cord-005453-4057qib7 3814 13 extensive extensive JJ cord-005453-4057qib7 3814 14 first first JJ cord-005453-4057qib7 3814 15 - - HYPH cord-005453-4057qib7 3814 16 pass pass NN cord-005453-4057qib7 3814 17 metabolism metabolism NN cord-005453-4057qib7 3814 18 via via IN cord-005453-4057qib7 3814 19 cytochrome cytochrome NN cord-005453-4057qib7 3814 20 P450 p450 NN cord-005453-4057qib7 3814 21 ( ( -LRB- cord-005453-4057qib7 3814 22 CYP CYP NNP cord-005453-4057qib7 3814 23 ) ) -RRB- cord-005453-4057qib7 3814 24 3A4 3A4 NNP cord-005453-4057qib7 3814 25 , , , cord-005453-4057qib7 3814 26 which which WDT cord-005453-4057qib7 3814 27 translates translate VBZ cord-005453-4057qib7 3814 28 to to IN cord-005453-4057qib7 3814 29 less less RBR cord-005453-4057qib7 3814 30 systemic systemic JJ cord-005453-4057qib7 3814 31 steroid steroid NN cord-005453-4057qib7 3814 32 - - HYPH cord-005453-4057qib7 3814 33 related relate VBN cord-005453-4057qib7 3814 34 effects effect NNS cord-005453-4057qib7 3814 35 . . . cord-005453-4057qib7 3815 1 However however RB cord-005453-4057qib7 3815 2 , , , cord-005453-4057qib7 3815 3 transplant transplant NN cord-005453-4057qib7 3815 4 patients patient NNS cord-005453-4057qib7 3815 5 are be VBP cord-005453-4057qib7 3815 6 often often RB cord-005453-4057qib7 3815 7 exposed expose VBN cord-005453-4057qib7 3815 8 to to IN cord-005453-4057qib7 3815 9 multiple multiple JJ cord-005453-4057qib7 3815 10 drugs drug NNS cord-005453-4057qib7 3815 11 , , , cord-005453-4057qib7 3815 12 among among IN cord-005453-4057qib7 3815 13 which which WDT cord-005453-4057qib7 3815 14 some some DT cord-005453-4057qib7 3815 15 agents agent NNS cord-005453-4057qib7 3815 16 act act VBP cord-005453-4057qib7 3815 17 as as IN cord-005453-4057qib7 3815 18 CYP3A4 cyp3a4 JJ cord-005453-4057qib7 3815 19 inhibitors inhibitor NNS cord-005453-4057qib7 3815 20 and and CC cord-005453-4057qib7 3815 21 therefore therefore RB cord-005453-4057qib7 3815 22 can can MD cord-005453-4057qib7 3815 23 increase increase VB cord-005453-4057qib7 3815 24 Budesonide Budesonide NNP cord-005453-4057qib7 3815 25 bioavailability bioavailability NN cord-005453-4057qib7 3815 26 and and CC cord-005453-4057qib7 3815 27 might may MD cord-005453-4057qib7 3815 28 lead lead VB cord-005453-4057qib7 3815 29 to to IN cord-005453-4057qib7 3815 30 systemic systemic JJ cord-005453-4057qib7 3815 31 toxicity toxicity NN cord-005453-4057qib7 3815 32 . . . cord-005453-4057qib7 3816 1 Azole Azole NNP cord-005453-4057qib7 3816 2 antifungal antifungal JJ cord-005453-4057qib7 3816 3 drugs drug NNS cord-005453-4057qib7 3816 4 are be VBP cord-005453-4057qib7 3816 5 probably probably RB cord-005453-4057qib7 3816 6 the the DT cord-005453-4057qib7 3816 7 most most RBS cord-005453-4057qib7 3816 8 common common JJ cord-005453-4057qib7 3816 9 concomitantly concomitantly RB cord-005453-4057qib7 3816 10 used use VBN cord-005453-4057qib7 3816 11 CYP3A4 cyp3a4 JJ cord-005453-4057qib7 3816 12 inhibitors inhibitor NNS cord-005453-4057qib7 3816 13 in in IN cord-005453-4057qib7 3816 14 transplant transplant NN cord-005453-4057qib7 3816 15 recipients recipient NNS cord-005453-4057qib7 3816 16 . . . cord-005453-4057qib7 3817 1 Methods method NNS cord-005453-4057qib7 3817 2 : : : cord-005453-4057qib7 3817 3 We -PRON- PRP cord-005453-4057qib7 3817 4 reviewed review VBD cord-005453-4057qib7 3817 5 allogeneic allogeneic JJ cord-005453-4057qib7 3817 6 SCT SCT NNP cord-005453-4057qib7 3817 7 records record NNS cord-005453-4057qib7 3817 8 for for IN cord-005453-4057qib7 3817 9 patients patient NNS cord-005453-4057qib7 3817 10 treated treat VBN cord-005453-4057qib7 3817 11 with with IN cord-005453-4057qib7 3817 12 oral oral JJ cord-005453-4057qib7 3817 13 Budesonide Budesonide NNP cord-005453-4057qib7 3817 14 for for IN cord-005453-4057qib7 3817 15 GI GI NNP cord-005453-4057qib7 3817 16 GVHD GVHD NNP cord-005453-4057qib7 3817 17 at at IN cord-005453-4057qib7 3817 18 our -PRON- PRP$ cord-005453-4057qib7 3817 19 transplant transplant NN cord-005453-4057qib7 3817 20 centre centre NN cord-005453-4057qib7 3817 21 between between IN cord-005453-4057qib7 3817 22 2015 2015 CD cord-005453-4057qib7 3817 23 and and CC cord-005453-4057qib7 3817 24 2018 2018 CD cord-005453-4057qib7 3817 25 retrospectively retrospectively RB cord-005453-4057qib7 3817 26 . . . cord-005453-4057qib7 3818 1 The the DT cord-005453-4057qib7 3818 2 aim aim NN cord-005453-4057qib7 3818 3 of of IN cord-005453-4057qib7 3818 4 the the DT cord-005453-4057qib7 3818 5 work work NN cord-005453-4057qib7 3818 6 was be VBD cord-005453-4057qib7 3818 7 to to TO cord-005453-4057qib7 3818 8 assess assess VB cord-005453-4057qib7 3818 9 the the DT cord-005453-4057qib7 3818 10 development development NN cord-005453-4057qib7 3818 11 of of IN cord-005453-4057qib7 3818 12 adrenal adrenal JJ cord-005453-4057qib7 3818 13 suppression suppression NN cord-005453-4057qib7 3818 14 with with IN cord-005453-4057qib7 3818 15 or or CC cord-005453-4057qib7 3818 16 without without IN cord-005453-4057qib7 3818 17 clinical clinical JJ cord-005453-4057qib7 3818 18 features feature NNS cord-005453-4057qib7 3818 19 of of IN cord-005453-4057qib7 3818 20 iatrogenic iatrogenic JJ cord-005453-4057qib7 3818 21 Cushing`s cushing`s NN cord-005453-4057qib7 3818 22 syndrome syndrome NN cord-005453-4057qib7 3818 23 . . . cord-005453-4057qib7 3819 1 The the DT cord-005453-4057qib7 3819 2 standard standard JJ cord-005453-4057qib7 3819 3 dose dose NN cord-005453-4057qib7 3819 4 of of IN cord-005453-4057qib7 3819 5 Budesonide Budesonide NNP cord-005453-4057qib7 3819 6 was be VBD cord-005453-4057qib7 3819 7 3 3 CD cord-005453-4057qib7 3819 8 mg mg NNP cord-005453-4057qib7 3819 9 three three CD cord-005453-4057qib7 3819 10 times time NNS cord-005453-4057qib7 3819 11 a a DT cord-005453-4057qib7 3819 12 day day NN cord-005453-4057qib7 3819 13 . . . cord-005453-4057qib7 3820 1 Patients patient NNS cord-005453-4057qib7 3820 2 receiving receive VBG cord-005453-4057qib7 3820 3 Prednisolone Prednisolone NNP cord-005453-4057qib7 3820 4 or or CC cord-005453-4057qib7 3820 5 other other JJ cord-005453-4057qib7 3820 6 glucocorticosteroids glucocorticosteroid NNS cord-005453-4057qib7 3820 7 and and CC cord-005453-4057qib7 3820 8 those those DT cord-005453-4057qib7 3820 9 with with IN cord-005453-4057qib7 3820 10 no no DT cord-005453-4057qib7 3820 11 available available JJ cord-005453-4057qib7 3820 12 serum serum NN cord-005453-4057qib7 3820 13 cortisol cortisol NN cord-005453-4057qib7 3820 14 level level NN cord-005453-4057qib7 3820 15 measurements measurement NNS cord-005453-4057qib7 3820 16 were be VBD cord-005453-4057qib7 3820 17 excluded exclude VBN cord-005453-4057qib7 3820 18 . . . cord-005453-4057qib7 3821 1 Results result NNS cord-005453-4057qib7 3821 2 : : : cord-005453-4057qib7 3822 1 Our -PRON- PRP$ cord-005453-4057qib7 3822 2 analyses analysis NNS cord-005453-4057qib7 3822 3 identified identify VBD cord-005453-4057qib7 3822 4 four four CD cord-005453-4057qib7 3822 5 allogeneic allogeneic NN cord-005453-4057qib7 3822 6 SCT SCT NNP cord-005453-4057qib7 3822 7 patients patient NNS cord-005453-4057qib7 3822 8 in in IN cord-005453-4057qib7 3822 9 whom whom WP cord-005453-4057qib7 3822 10 adrenal adrenal JJ cord-005453-4057qib7 3822 11 suppression suppression NN cord-005453-4057qib7 3822 12 was be VBD cord-005453-4057qib7 3822 13 diagnosed diagnose VBN cord-005453-4057qib7 3822 14 with with IN cord-005453-4057qib7 3822 15 undetectable undetectable JJ cord-005453-4057qib7 3822 16 serum serum NN cord-005453-4057qib7 3822 17 cortisol cortisol NN cord-005453-4057qib7 3822 18 levels level NNS cord-005453-4057qib7 3822 19 during during IN cord-005453-4057qib7 3822 20 oral oral JJ cord-005453-4057qib7 3822 21 Budesonide Budesonide NNP cord-005453-4057qib7 3822 22 treatment treatment NN cord-005453-4057qib7 3822 23 . . . cord-005453-4057qib7 3823 1 Of of IN cord-005453-4057qib7 3823 2 these these DT cord-005453-4057qib7 3823 3 patients patient NNS cord-005453-4057qib7 3823 4 two two CD cord-005453-4057qib7 3823 5 developed develop VBN cord-005453-4057qib7 3823 6 iatrogenic iatrogenic JJ cord-005453-4057qib7 3823 7 Cushing`s cushing`s NN cord-005453-4057qib7 3823 8 syndrome syndrome NN cord-005453-4057qib7 3823 9 and and CC cord-005453-4057qib7 3823 10 both both DT cord-005453-4057qib7 3823 11 patients patient NNS cord-005453-4057qib7 3823 12 were be VBD cord-005453-4057qib7 3823 13 treated treat VBN cord-005453-4057qib7 3823 14 with with IN cord-005453-4057qib7 3823 15 CYP3A4 cyp3a4 JJ cord-005453-4057qib7 3823 16 inhibitors inhibitor NNS cord-005453-4057qib7 3823 17 concomitantly concomitantly RB cord-005453-4057qib7 3823 18 : : : cord-005453-4057qib7 3823 19 1 1 CD cord-005453-4057qib7 3823 20 . . . cord-005453-4057qib7 3824 1 Clarithromycin Clarithromycin NNP cord-005453-4057qib7 3824 2 and and CC cord-005453-4057qib7 3824 3 Fluconazole Fluconazole NNP cord-005453-4057qib7 3824 4 ; ; : cord-005453-4057qib7 3824 5 2 2 CD cord-005453-4057qib7 3824 6 . . . cord-005453-4057qib7 3825 1 Clarithomycin Clarithomycin NNP cord-005453-4057qib7 3825 2 and and CC cord-005453-4057qib7 3825 3 Voriconazole Voriconazole NNP cord-005453-4057qib7 3825 4 . . . cord-005453-4057qib7 3826 1 The the DT cord-005453-4057qib7 3826 2 development development NN cord-005453-4057qib7 3826 3 was be VBD cord-005453-4057qib7 3826 4 rapid rapid JJ cord-005453-4057qib7 3826 5 ( ( -LRB- cord-005453-4057qib7 3826 6 within within IN cord-005453-4057qib7 3826 7 3 3 CD cord-005453-4057qib7 3826 8 and and CC cord-005453-4057qib7 3826 9 4 4 CD cord-005453-4057qib7 3826 10 weeks week NNS cord-005453-4057qib7 3826 11 ) ) -RRB- cord-005453-4057qib7 3826 12 . . . cord-005453-4057qib7 3827 1 Symptoms symptom NNS cord-005453-4057qib7 3827 2 included include VBD cord-005453-4057qib7 3827 3 morphological morphological JJ cord-005453-4057qib7 3827 4 features feature NNS cord-005453-4057qib7 3827 5 such such JJ cord-005453-4057qib7 3827 6 as as IN cord-005453-4057qib7 3827 7 moon moon NN cord-005453-4057qib7 3827 8 face face NN cord-005453-4057qib7 3827 9 , , , cord-005453-4057qib7 3827 10 high high JJ cord-005453-4057qib7 3827 11 blood blood NN cord-005453-4057qib7 3827 12 pressure pressure NN cord-005453-4057qib7 3827 13 , , , cord-005453-4057qib7 3827 14 weight weight NN cord-005453-4057qib7 3827 15 gain gain NN cord-005453-4057qib7 3827 16 , , , cord-005453-4057qib7 3827 17 peripheral peripheral JJ cord-005453-4057qib7 3827 18 oedema oedema NN cord-005453-4057qib7 3827 19 and and CC cord-005453-4057qib7 3827 20 proximal proximal JJ cord-005453-4057qib7 3827 21 myopathy myopathy NN cord-005453-4057qib7 3827 22 . . . cord-005453-4057qib7 3828 1 Symptoms symptom NNS cord-005453-4057qib7 3828 2 resolved resolve VBD cord-005453-4057qib7 3828 3 gradually gradually RB cord-005453-4057qib7 3828 4 following follow VBG cord-005453-4057qib7 3828 5 cessation cessation NN cord-005453-4057qib7 3828 6 of of IN cord-005453-4057qib7 3828 7 azole azole NNP cord-005453-4057qib7 3828 8 antifungal antifungal JJ cord-005453-4057qib7 3828 9 agents agent NNS cord-005453-4057qib7 3828 10 and and CC cord-005453-4057qib7 3828 11 on on IN cord-005453-4057qib7 3828 12 gradual gradual JJ cord-005453-4057qib7 3828 13 weaning weaning NN cord-005453-4057qib7 3828 14 of of IN cord-005453-4057qib7 3828 15 Budesonide Budesonide NNP cord-005453-4057qib7 3828 16 . . . cord-005453-4057qib7 3829 1 Conclusions conclusion NNS cord-005453-4057qib7 3829 2 : : : cord-005453-4057qib7 3830 1 Although although IN cord-005453-4057qib7 3830 2 single single JJ cord-005453-4057qib7 3830 3 agent agent NN cord-005453-4057qib7 3830 4 Budesonide Budesonide NNP cord-005453-4057qib7 3830 5 treatment treatment NN cord-005453-4057qib7 3830 6 given give VBN cord-005453-4057qib7 3830 7 for for IN cord-005453-4057qib7 3830 8 GI GI NNP cord-005453-4057qib7 3830 9 GVHD GVHD NNP cord-005453-4057qib7 3830 10 is be VBZ cord-005453-4057qib7 3830 11 rarely rarely RB cord-005453-4057qib7 3830 12 associated associate VBN cord-005453-4057qib7 3830 13 with with IN cord-005453-4057qib7 3830 14 systemic systemic JJ cord-005453-4057qib7 3830 15 side side NN cord-005453-4057qib7 3830 16 effects effect NNS cord-005453-4057qib7 3830 17 , , , cord-005453-4057qib7 3830 18 patients patient NNS cord-005453-4057qib7 3830 19 on on IN cord-005453-4057qib7 3830 20 azole azole NNP cord-005453-4057qib7 3830 21 antifungal antifungal JJ cord-005453-4057qib7 3830 22 drugs drug NNS cord-005453-4057qib7 3830 23 and and CC cord-005453-4057qib7 3830 24 macrolide macrolide NN cord-005453-4057qib7 3830 25 antibiotics antibiotic NNS cord-005453-4057qib7 3830 26 are be VBP cord-005453-4057qib7 3830 27 at at IN cord-005453-4057qib7 3830 28 higher high JJR cord-005453-4057qib7 3830 29 risk risk NN cord-005453-4057qib7 3830 30 of of IN cord-005453-4057qib7 3830 31 systemic systemic JJ cord-005453-4057qib7 3830 32 toxicity toxicity NN cord-005453-4057qib7 3830 33 due due IN cord-005453-4057qib7 3830 34 to to IN cord-005453-4057qib7 3830 35 drug drug NN cord-005453-4057qib7 3830 36 interactions interaction NNS cord-005453-4057qib7 3830 37 . . . cord-005453-4057qib7 3831 1 Patients patient NNS cord-005453-4057qib7 3831 2 who who WP cord-005453-4057qib7 3831 3 are be VBP cord-005453-4057qib7 3831 4 allergic allergic JJ cord-005453-4057qib7 3831 5 to to IN cord-005453-4057qib7 3831 6 Penicillin Penicillin NNP cord-005453-4057qib7 3831 7 and and CC cord-005453-4057qib7 3831 8 receive receive VB cord-005453-4057qib7 3831 9 macrolide macrolide NN cord-005453-4057qib7 3831 10 - - HYPH cord-005453-4057qib7 3831 11 based base VBN cord-005453-4057qib7 3831 12 prophylaxis prophylaxis NN cord-005453-4057qib7 3831 13 can can MD cord-005453-4057qib7 3831 14 be be VB cord-005453-4057qib7 3831 15 especially especially RB cord-005453-4057qib7 3831 16 vulnerable vulnerable JJ cord-005453-4057qib7 3831 17 . . . cord-005453-4057qib7 3832 1 To to IN cord-005453-4057qib7 3832 2 our -PRON- PRP$ cord-005453-4057qib7 3832 3 knowledge knowledge NN cord-005453-4057qib7 3832 4 the the DT cord-005453-4057qib7 3832 5 number number NN cord-005453-4057qib7 3832 6 of of IN cord-005453-4057qib7 3832 7 cases case NNS cord-005453-4057qib7 3832 8 reported report VBN cord-005453-4057qib7 3832 9 in in IN cord-005453-4057qib7 3832 10 literature literature NN cord-005453-4057qib7 3832 11 about about IN cord-005453-4057qib7 3832 12 systemic systemic JJ cord-005453-4057qib7 3832 13 effects effect NNS cord-005453-4057qib7 3832 14 of of IN cord-005453-4057qib7 3832 15 oral oral JJ cord-005453-4057qib7 3832 16 Budesonide Budesonide NNP cord-005453-4057qib7 3832 17 in in IN cord-005453-4057qib7 3832 18 transplant transplant NN cord-005453-4057qib7 3832 19 recipients recipient NNS cord-005453-4057qib7 3832 20 is be VBZ cord-005453-4057qib7 3832 21 less less JJR cord-005453-4057qib7 3832 22 than than IN cord-005453-4057qib7 3832 23 10 10 CD cord-005453-4057qib7 3832 24 . . . cord-005453-4057qib7 3833 1 Our -PRON- PRP$ cord-005453-4057qib7 3833 2 observation observation NN cord-005453-4057qib7 3833 3 supports support VBZ cord-005453-4057qib7 3833 4 previous previous JJ cord-005453-4057qib7 3833 5 reports report NNS cord-005453-4057qib7 3833 6 on on IN cord-005453-4057qib7 3833 7 the the DT cord-005453-4057qib7 3833 8 potential potential NN cord-005453-4057qib7 3833 9 of of IN cord-005453-4057qib7 3833 10 oral oral JJ cord-005453-4057qib7 3833 11 Budesonide Budesonide NNP cord-005453-4057qib7 3833 12 to to TO cord-005453-4057qib7 3833 13 induce induce VB cord-005453-4057qib7 3833 14 systemic systemic JJ cord-005453-4057qib7 3833 15 effects effect NNS cord-005453-4057qib7 3833 16 . . . cord-005453-4057qib7 3834 1 We -PRON- PRP cord-005453-4057qib7 3834 2 therefore therefore RB cord-005453-4057qib7 3834 3 advise advise VBP cord-005453-4057qib7 3834 4 careful careful JJ cord-005453-4057qib7 3834 5 monitoring monitoring NN cord-005453-4057qib7 3834 6 of of IN cord-005453-4057qib7 3834 7 patients patient NNS cord-005453-4057qib7 3834 8 treated treat VBN cord-005453-4057qib7 3834 9 with with IN cord-005453-4057qib7 3834 10 Budesonide Budesonide NNP cord-005453-4057qib7 3834 11 in in IN cord-005453-4057qib7 3834 12 combination combination NN cord-005453-4057qib7 3834 13 with with IN cord-005453-4057qib7 3834 14 CYP3A4 CYP3A4 NNP cord-005453-4057qib7 3834 15 inhibitors inhibitor NNS cord-005453-4057qib7 3834 16 , , , cord-005453-4057qib7 3834 17 including include VBG cord-005453-4057qib7 3834 18 antimicrobial antimicrobial JJ cord-005453-4057qib7 3834 19 agents agent NNS cord-005453-4057qib7 3834 20 routinely routinely RB cord-005453-4057qib7 3834 21 used use VBN cord-005453-4057qib7 3834 22 in in IN cord-005453-4057qib7 3834 23 SCT SCT NNP cord-005453-4057qib7 3834 24 . . . cord-005453-4057qib7 3835 1 Disclosure disclosure NN cord-005453-4057qib7 3835 2 : : : cord-005453-4057qib7 3836 1 None none NN cord-005453-4057qib7 3836 2 Implemented implement VBD cord-005453-4057qib7 3836 3 strategies strategy NNS cord-005453-4057qib7 3836 4 to to TO cord-005453-4057qib7 3836 5 overcome overcome VB cord-005453-4057qib7 3836 6 barriers barrier NNS cord-005453-4057qib7 3836 7 in in IN cord-005453-4057qib7 3836 8 the the DT cord-005453-4057qib7 3836 9 establishment establishment NN cord-005453-4057qib7 3836 10 of of IN cord-005453-4057qib7 3836 11 a a DT cord-005453-4057qib7 3836 12 consolidated consolidated JJ cord-005453-4057qib7 3836 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 3836 14 stem stem NN cord-005453-4057qib7 3836 15 cell cell NN cord-005453-4057qib7 3836 16 transplantation transplantation NN cord-005453-4057qib7 3836 17 program program NN cord-005453-4057qib7 3836 18 in in IN cord-005453-4057qib7 3836 19 a a DT cord-005453-4057qib7 3836 20 developing develop VBG cord-005453-4057qib7 3836 21 country country NN cord-005453-4057qib7 3836 22 Background background NN cord-005453-4057qib7 3836 23 : : : cord-005453-4057qib7 3836 24 The the DT cord-005453-4057qib7 3836 25 National National NNP cord-005453-4057qib7 3836 26 Institute Institute NNP cord-005453-4057qib7 3836 27 of of IN cord-005453-4057qib7 3836 28 Medical Medical NNP cord-005453-4057qib7 3836 29 Sciences Sciences NNPS cord-005453-4057qib7 3836 30 and and CC cord-005453-4057qib7 3836 31 Nutrition Nutrition NNP cord-005453-4057qib7 3836 32 " " `` cord-005453-4057qib7 3836 33 Salvador Salvador NNP cord-005453-4057qib7 3836 34 Zubiran Zubiran NNP cord-005453-4057qib7 3836 35 " " '' cord-005453-4057qib7 3836 36 is be VBZ cord-005453-4057qib7 3836 37 a a DT cord-005453-4057qib7 3836 38 National National NNP cord-005453-4057qib7 3836 39 Health Health NNP cord-005453-4057qib7 3836 40 Institute Institute NNP cord-005453-4057qib7 3836 41 located locate VBN cord-005453-4057qib7 3836 42 in in IN cord-005453-4057qib7 3836 43 Mexico Mexico NNP cord-005453-4057qib7 3836 44 City City NNP cord-005453-4057qib7 3836 45 . . . cord-005453-4057qib7 3837 1 Although although IN cord-005453-4057qib7 3837 2 Mexico Mexico NNP cord-005453-4057qib7 3837 3 is be VBZ cord-005453-4057qib7 3837 4 considered consider VBN cord-005453-4057qib7 3837 5 an an DT cord-005453-4057qib7 3837 6 upper upper JJ cord-005453-4057qib7 3837 7 - - HYPH cord-005453-4057qib7 3837 8 middle middle JJ cord-005453-4057qib7 3837 9 income income NN cord-005453-4057qib7 3837 10 country country NN cord-005453-4057qib7 3837 11 , , , cord-005453-4057qib7 3837 12 more more JJR cord-005453-4057qib7 3837 13 than than IN cord-005453-4057qib7 3837 14 50 50 CD cord-005453-4057qib7 3837 15 % % NN cord-005453-4057qib7 3837 16 of of IN cord-005453-4057qib7 3837 17 the the DT cord-005453-4057qib7 3837 18 population population NN cord-005453-4057qib7 3837 19 lives live VBZ cord-005453-4057qib7 3837 20 in in IN cord-005453-4057qib7 3837 21 poverty poverty NN cord-005453-4057qib7 3837 22 without without IN cord-005453-4057qib7 3837 23 health health NN cord-005453-4057qib7 3837 24 care care NN cord-005453-4057qib7 3837 25 coverage coverage NN cord-005453-4057qib7 3837 26 and and CC cord-005453-4057qib7 3837 27 patients patient NNS cord-005453-4057qib7 3837 28 within within IN cord-005453-4057qib7 3837 29 this this DT cord-005453-4057qib7 3837 30 social social JJ cord-005453-4057qib7 3837 31 stratum stratum NN cord-005453-4057qib7 3837 32 are be VBP cord-005453-4057qib7 3837 33 referred refer VBN cord-005453-4057qib7 3837 34 to to IN cord-005453-4057qib7 3837 35 our -PRON- PRP$ cord-005453-4057qib7 3837 36 Institution Institution NNP cord-005453-4057qib7 3837 37 . . . cord-005453-4057qib7 3838 1 The the DT cord-005453-4057qib7 3838 2 first first JJ cord-005453-4057qib7 3838 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 3838 4 stem stem NN cord-005453-4057qib7 3838 5 cell cell NN cord-005453-4057qib7 3838 6 transplantation transplantation NN cord-005453-4057qib7 3838 7 ( ( -LRB- cord-005453-4057qib7 3838 8 HSCT HSCT NNP cord-005453-4057qib7 3838 9 ) ) -RRB- cord-005453-4057qib7 3838 10 in in IN cord-005453-4057qib7 3838 11 Mexico Mexico NNP cord-005453-4057qib7 3838 12 was be VBD cord-005453-4057qib7 3838 13 performed perform VBN cord-005453-4057qib7 3838 14 at at IN cord-005453-4057qib7 3838 15 our -PRON- PRP$ cord-005453-4057qib7 3838 16 Institution Institution NNP cord-005453-4057qib7 3838 17 in in IN cord-005453-4057qib7 3838 18 1980 1980 CD cord-005453-4057qib7 3838 19 . . . cord-005453-4057qib7 3839 1 From from IN cord-005453-4057qib7 3839 2 this this DT cord-005453-4057qib7 3839 3 year year NN cord-005453-4057qib7 3839 4 until until IN cord-005453-4057qib7 3839 5 1997 1997 CD cord-005453-4057qib7 3839 6 , , , cord-005453-4057qib7 3839 7 HSCT HSCT NNP cord-005453-4057qib7 3839 8 were be VBD cord-005453-4057qib7 3839 9 sporadically sporadically RB cord-005453-4057qib7 3839 10 performed perform VBN cord-005453-4057qib7 3839 11 ( ( -LRB- cord-005453-4057qib7 3839 12 n=33 n=33 NNP cord-005453-4057qib7 3839 13 ) ) -RRB- cord-005453-4057qib7 3839 14 , , , cord-005453-4057qib7 3839 15 showing show VBG cord-005453-4057qib7 3839 16 a a DT cord-005453-4057qib7 3839 17 poor poor JJ cord-005453-4057qib7 3839 18 overall overall JJ cord-005453-4057qib7 3839 19 survival survival NN cord-005453-4057qib7 3839 20 ( ( -LRB- cord-005453-4057qib7 3839 21 OS OS NNP cord-005453-4057qib7 3839 22 ) ) -RRB- cord-005453-4057qib7 3839 23 and and CC cord-005453-4057qib7 3839 24 high high JJ cord-005453-4057qib7 3839 25 non non JJ cord-005453-4057qib7 3839 26 - - JJ cord-005453-4057qib7 3839 27 relapse relapse JJ cord-005453-4057qib7 3839 28 mortality mortality NN cord-005453-4057qib7 3839 29 ( ( -LRB- cord-005453-4057qib7 3839 30 NRM NRM NNP cord-005453-4057qib7 3839 31 ) ) -RRB- cord-005453-4057qib7 3839 32 . . . cord-005453-4057qib7 3840 1 These these DT cord-005453-4057qib7 3840 2 outcomes outcome NNS cord-005453-4057qib7 3840 3 resulted result VBD cord-005453-4057qib7 3840 4 from from IN cord-005453-4057qib7 3840 5 an an DT cord-005453-4057qib7 3840 6 unstructured unstructured JJ cord-005453-4057qib7 3840 7 HSCT HSCT NNP cord-005453-4057qib7 3840 8 Program Program NNP cord-005453-4057qib7 3840 9 , , , cord-005453-4057qib7 3840 10 limitedresources limitedresource NNS cord-005453-4057qib7 3840 11 , , , cord-005453-4057qib7 3840 12 patient patient JJ cord-005453-4057qib7 3840 13 low low JJ cord-005453-4057qib7 3840 14 socioeconomic socioeconomic JJ cord-005453-4057qib7 3840 15 status status NN cord-005453-4057qib7 3840 16 , , , cord-005453-4057qib7 3840 17 and and CC cord-005453-4057qib7 3840 18 paucity paucity NN cord-005453-4057qib7 3840 19 of of IN cord-005453-4057qib7 3840 20 population population NN cord-005453-4057qib7 3840 21 - - HYPH cord-005453-4057qib7 3840 22 adapted adapt VBN cord-005453-4057qib7 3840 23 procedures procedure NNS cord-005453-4057qib7 3840 24 . . . cord-005453-4057qib7 3841 1 In in IN cord-005453-4057qib7 3841 2 1998 1998 CD cord-005453-4057qib7 3841 3 , , , cord-005453-4057qib7 3841 4 according accord VBG cord-005453-4057qib7 3841 5 to to IN cord-005453-4057qib7 3841 6 these these DT cord-005453-4057qib7 3841 7 results result NNS cord-005453-4057qib7 3841 8 , , , cord-005453-4057qib7 3841 9 a a DT cord-005453-4057qib7 3841 10 decision decision NN cord-005453-4057qib7 3841 11 to to TO cord-005453-4057qib7 3841 12 establish establish VB cord-005453-4057qib7 3841 13 a a DT cord-005453-4057qib7 3841 14 HSCT HSCT NNP cord-005453-4057qib7 3841 15 Program Program NNP cord-005453-4057qib7 3841 16 was be VBD cord-005453-4057qib7 3841 17 made make VBN cord-005453-4057qib7 3841 18 . . . cord-005453-4057qib7 3842 1 Therefore therefore RB cord-005453-4057qib7 3842 2 , , , cord-005453-4057qib7 3842 3 in in IN cord-005453-4057qib7 3842 4 order order NN cord-005453-4057qib7 3842 5 to to TO cord-005453-4057qib7 3842 6 set set VB cord-005453-4057qib7 3842 7 up up RP cord-005453-4057qib7 3842 8 a a DT cord-005453-4057qib7 3842 9 successful successful JJ cord-005453-4057qib7 3842 10 HSCT HSCT NNP cord-005453-4057qib7 3842 11 Program Program NNP cord-005453-4057qib7 3842 12 , , , cord-005453-4057qib7 3842 13 implementation implementation NN cord-005453-4057qib7 3842 14 of of IN cord-005453-4057qib7 3842 15 financial financial JJ cord-005453-4057qib7 3842 16 and and CC cord-005453-4057qib7 3842 17 medical medical JJ cord-005453-4057qib7 3842 18 strategies strategy NNS cord-005453-4057qib7 3842 19 were be VBD cord-005453-4057qib7 3842 20 necessary necessary JJ cord-005453-4057qib7 3842 21 . . . cord-005453-4057qib7 3843 1 The the DT cord-005453-4057qib7 3843 2 objectives objective NNS cord-005453-4057qib7 3843 3 of of IN cord-005453-4057qib7 3843 4 this this DT cord-005453-4057qib7 3843 5 study study NN cord-005453-4057qib7 3843 6 were be VBD cord-005453-4057qib7 3843 7 to to TO cord-005453-4057qib7 3843 8 describe describe VB cord-005453-4057qib7 3843 9 the the DT cord-005453-4057qib7 3843 10 barriers barrier NNS cord-005453-4057qib7 3843 11 and and CC cord-005453-4057qib7 3843 12 implemented implement VBN cord-005453-4057qib7 3843 13 strategies strategy NNS cord-005453-4057qib7 3843 14 for for IN cord-005453-4057qib7 3843 15 the the DT cord-005453-4057qib7 3843 16 establishment establishment NN cord-005453-4057qib7 3843 17 of of IN cord-005453-4057qib7 3843 18 a a DT cord-005453-4057qib7 3843 19 HSCT HSCT NNP cord-005453-4057qib7 3843 20 Program Program NNP cord-005453-4057qib7 3843 21 in in IN cord-005453-4057qib7 3843 22 Mexico Mexico NNP cord-005453-4057qib7 3843 23 along along IN cord-005453-4057qib7 3843 24 with with IN cord-005453-4057qib7 3843 25 the the DT cord-005453-4057qib7 3843 26 outcomes outcome NNS cord-005453-4057qib7 3843 27 of of IN cord-005453-4057qib7 3843 28 patients patient NNS cord-005453-4057qib7 3843 29 undergoing undergo VBG cord-005453-4057qib7 3843 30 this this DT cord-005453-4057qib7 3843 31 procedure procedure NN cord-005453-4057qib7 3843 32 throughout throughout IN cord-005453-4057qib7 3843 33 the the DT cord-005453-4057qib7 3843 34 reorganization reorganization NN cord-005453-4057qib7 3843 35 of of IN cord-005453-4057qib7 3843 36 the the DT cord-005453-4057qib7 3843 37 Program Program NNP cord-005453-4057qib7 3843 38 . . . cord-005453-4057qib7 3844 1 Methods method NNS cord-005453-4057qib7 3844 2 : : : cord-005453-4057qib7 3844 3 This this DT cord-005453-4057qib7 3844 4 study study NN cord-005453-4057qib7 3844 5 is be VBZ cord-005453-4057qib7 3844 6 a a DT cord-005453-4057qib7 3844 7 health health NN cord-005453-4057qib7 3844 8 services service NNS cord-005453-4057qib7 3844 9 research research NN cord-005453-4057qib7 3844 10 . . . cord-005453-4057qib7 3845 1 Barriers barrier NNS cord-005453-4057qib7 3845 2 were be VBD cord-005453-4057qib7 3845 3 detected detect VBN cord-005453-4057qib7 3845 4 based base VBN cord-005453-4057qib7 3845 5 on on IN cord-005453-4057qib7 3845 6 the the DT cord-005453-4057qib7 3845 7 results result NNS cord-005453-4057qib7 3845 8 of of IN cord-005453-4057qib7 3845 9 the the DT cord-005453-4057qib7 3845 10 HSCT HSCT NNP cord-005453-4057qib7 3845 11 Program Program NNP cord-005453-4057qib7 3845 12 from from IN cord-005453-4057qib7 3845 13 1980 1980 CD cord-005453-4057qib7 3845 14 - - SYM cord-005453-4057qib7 3845 15 1997 1997 CD cord-005453-4057qib7 3845 16 ( ( -LRB- cord-005453-4057qib7 3845 17 not not RB cord-005453-4057qib7 3845 18 shown show VBN cord-005453-4057qib7 3845 19 ) ) -RRB- cord-005453-4057qib7 3845 20 . . . cord-005453-4057qib7 3846 1 Table table NN cord-005453-4057qib7 3846 2 1 1 CD cord-005453-4057qib7 3846 3 shows show VBZ cord-005453-4057qib7 3846 4 the the DT cord-005453-4057qib7 3846 5 financial financial JJ cord-005453-4057qib7 3846 6 , , , cord-005453-4057qib7 3846 7 medical medical JJ cord-005453-4057qib7 3846 8 , , , cord-005453-4057qib7 3846 9 and and CC cord-005453-4057qib7 3846 10 research research NN cord-005453-4057qib7 3846 11 strategies strategy NNS cord-005453-4057qib7 3846 12 that that WDT cord-005453-4057qib7 3846 13 were be VBD cord-005453-4057qib7 3846 14 implemented implement VBN cord-005453-4057qib7 3846 15 for for IN cord-005453-4057qib7 3846 16 each each DT cord-005453-4057qib7 3846 17 barrier barrier NN cord-005453-4057qib7 3846 18 . . . cord-005453-4057qib7 3847 1 Results result NNS cord-005453-4057qib7 3847 2 : : : cord-005453-4057qib7 3848 1 From from IN cord-005453-4057qib7 3848 2 November November NNP cord-005453-4057qib7 3848 3 1998 1998 CD cord-005453-4057qib7 3848 4 to to IN cord-005453-4057qib7 3848 5 November November NNP cord-005453-4057qib7 3848 6 2018 2018 CD cord-005453-4057qib7 3848 7 , , , cord-005453-4057qib7 3848 8 363 363 CD cord-005453-4057qib7 3848 9 HSCT HSCT NNP cord-005453-4057qib7 3848 10 have have VBP cord-005453-4057qib7 3848 11 been be VBN cord-005453-4057qib7 3848 12 performed perform VBN cord-005453-4057qib7 3848 13 in in IN cord-005453-4057qib7 3848 14 322 322 CD cord-005453-4057qib7 3848 15 patients patient NNS cord-005453-4057qib7 3848 16 at at IN cord-005453-4057qib7 3848 17 our -PRON- PRP$ cord-005453-4057qib7 3848 18 Institution Institution NNP cord-005453-4057qib7 3848 19 . . . cord-005453-4057qib7 3849 1 Most Most JJS cord-005453-4057qib7 3849 2 HSCT HSCT NNP cord-005453-4057qib7 3849 3 were be VBD cord-005453-4057qib7 3849 4 autologous autologous JJ cord-005453-4057qib7 3849 5 ( ( -LRB- cord-005453-4057qib7 3849 6 n=213 n=213 NNP cord-005453-4057qib7 3849 7 , , , cord-005453-4057qib7 3849 8 59 59 CD cord-005453-4057qib7 3849 9 % % NN cord-005453-4057qib7 3849 10 ) ) -RRB- cord-005453-4057qib7 3849 11 . . . cord-005453-4057qib7 3850 1 Forty forty CD cord-005453-4057qib7 3850 2 one one CD cord-005453-4057qib7 3850 3 patients patient NNS cord-005453-4057qib7 3850 4 underwent undergo VBD cord-005453-4057qib7 3850 5 2 2 CD cord-005453-4057qib7 3850 6 HSCT HSCT NNP cord-005453-4057qib7 3850 7 . . . cord-005453-4057qib7 3851 1 From from IN cord-005453-4057qib7 3851 2 the the DT cord-005453-4057qib7 3851 3 322 322 CD cord-005453-4057qib7 3851 4 patients patient NNS cord-005453-4057qib7 3851 5 , , , cord-005453-4057qib7 3851 6 most most JJS cord-005453-4057qib7 3851 7 were be VBD cord-005453-4057qib7 3851 8 males male NNS cord-005453-4057qib7 3851 9 ( ( -LRB- cord-005453-4057qib7 3851 10 n=196 n=196 ADD cord-005453-4057qib7 3851 11 , , , cord-005453-4057qib7 3851 12 61 61 CD cord-005453-4057qib7 3851 13 % % NN cord-005453-4057qib7 3851 14 ) ) -RRB- cord-005453-4057qib7 3851 15 and and CC cord-005453-4057qib7 3851 16 the the DT cord-005453-4057qib7 3851 17 median median JJ cord-005453-4057qib7 3851 18 age age NN cord-005453-4057qib7 3851 19 was be VBD cord-005453-4057qib7 3851 20 33.5 33.5 CD cord-005453-4057qib7 3851 21 years year NNS cord-005453-4057qib7 3851 22 ( ( -LRB- cord-005453-4057qib7 3851 23 range range NN cord-005453-4057qib7 3851 24 , , , cord-005453-4057qib7 3851 25 15 15 CD cord-005453-4057qib7 3851 26 - - SYM cord-005453-4057qib7 3851 27 65 65 CD cord-005453-4057qib7 3851 28 ) ) -RRB- cord-005453-4057qib7 3851 29 . . . cord-005453-4057qib7 3852 1 The the DT cord-005453-4057qib7 3852 2 most most RBS cord-005453-4057qib7 3852 3 frequent frequent JJ cord-005453-4057qib7 3852 4 underlying underlie VBG cord-005453-4057qib7 3852 5 diseases disease NNS cord-005453-4057qib7 3852 6 for for IN cord-005453-4057qib7 3852 7 auto auto NN cord-005453-4057qib7 3852 8 - - HYPH cord-005453-4057qib7 3852 9 HSCT HSCT NNP cord-005453-4057qib7 3852 10 were be VBD cord-005453-4057qib7 3852 11 lymphomas lymphoma NNS cord-005453-4057qib7 3852 12 ( ( -LRB- cord-005453-4057qib7 3852 13 n=68 n=68 JJ cord-005453-4057qib7 3852 14 , , , cord-005453-4057qib7 3852 15 36 36 CD cord-005453-4057qib7 3852 16 % % NN cord-005453-4057qib7 3852 17 ) ) -RRB- cord-005453-4057qib7 3852 18 , , , cord-005453-4057qib7 3852 19 non non JJ cord-005453-4057qib7 3852 20 - - JJ cord-005453-4057qib7 3852 21 seminomatous seminomatous JJ cord-005453-4057qib7 3852 22 germ germ NN cord-005453-4057qib7 3852 23 cell cell NN cord-005453-4057qib7 3852 24 tumors tumor NNS cord-005453-4057qib7 3852 25 ( ( -LRB- cord-005453-4057qib7 3852 26 n=42 n=42 NN cord-005453-4057qib7 3852 27 , , , cord-005453-4057qib7 3852 28 22 22 CD cord-005453-4057qib7 3852 29 % % NN cord-005453-4057qib7 3852 30 ) ) -RRB- cord-005453-4057qib7 3852 31 , , , cord-005453-4057qib7 3852 32 and and CC cord-005453-4057qib7 3852 33 multiple multiple JJ cord-005453-4057qib7 3852 34 myeloma myeloma NN cord-005453-4057qib7 3852 35 ( ( -LRB- cord-005453-4057qib7 3853 1 n=42 n=42 NNP cord-005453-4057qib7 3853 2 , , , cord-005453-4057qib7 3853 3 22 22 CD cord-005453-4057qib7 3853 4 % % NN cord-005453-4057qib7 3853 5 ) ) -RRB- cord-005453-4057qib7 3853 6 . . . cord-005453-4057qib7 3854 1 Acute acute JJ cord-005453-4057qib7 3854 2 leukemias leukemia NNS cord-005453-4057qib7 3854 3 ( ( -LRB- cord-005453-4057qib7 3855 1 n=41 n=41 RB cord-005453-4057qib7 3855 2 , , , cord-005453-4057qib7 3855 3 34 34 CD cord-005453-4057qib7 3855 4 % % NN cord-005453-4057qib7 3855 5 ) ) -RRB- cord-005453-4057qib7 3855 6 , , , cord-005453-4057qib7 3855 7 aplastic aplastic JJ cord-005453-4057qib7 3855 8 anemia anemia NN cord-005453-4057qib7 3855 9 ( ( -LRB- cord-005453-4057qib7 3855 10 n=25 n=25 NN cord-005453-4057qib7 3855 11 , , , cord-005453-4057qib7 3855 12 21 21 CD cord-005453-4057qib7 3855 13 % % NN cord-005453-4057qib7 3855 14 ) ) -RRB- cord-005453-4057qib7 3855 15 , , , cord-005453-4057qib7 3855 16 and and CC cord-005453-4057qib7 3855 17 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 3855 18 syndromes syndrome NNS cord-005453-4057qib7 3855 19 ( ( -LRB- cord-005453-4057qib7 3855 20 n=20 n=20 NN cord-005453-4057qib7 3855 21 , , , cord-005453-4057qib7 3855 22 17 17 CD cord-005453-4057qib7 3855 23 % % NN cord-005453-4057qib7 3855 24 ) ) -RRB- cord-005453-4057qib7 3855 25 were be VBD cord-005453-4057qib7 3855 26 the the DT cord-005453-4057qib7 3855 27 most most RBS cord-005453-4057qib7 3855 28 frequent frequent JJ cord-005453-4057qib7 3855 29 diagnosis diagnosis NN cord-005453-4057qib7 3855 30 for for IN cord-005453-4057qib7 3855 31 patients patient NNS cord-005453-4057qib7 3855 32 undergoing undergo VBG cord-005453-4057qib7 3855 33 allo allo NN cord-005453-4057qib7 3855 34 - - HYPH cord-005453-4057qib7 3855 35 HSCT HSCT NNP cord-005453-4057qib7 3855 36 ; ; : cord-005453-4057qib7 3855 37 and and CC cord-005453-4057qib7 3855 38 acute acute JJ cord-005453-4057qib7 3855 39 leukemia leukemia NN cord-005453-4057qib7 3855 40 was be VBD cord-005453-4057qib7 3855 41 the the DT cord-005453-4057qib7 3855 42 most most RBS cord-005453-4057qib7 3855 43 frequent frequent JJ cord-005453-4057qib7 3855 44 diagnosis diagnosis NN cord-005453-4057qib7 3855 45 for for IN cord-005453-4057qib7 3855 46 patients patient NNS cord-005453-4057qib7 3855 47 undergoing undergo VBG cord-005453-4057qib7 3855 48 haploidentical haploidentical JJ cord-005453-4057qib7 3855 49 HSCT HSCT NNP cord-005453-4057qib7 3855 50 ( ( -LRB- cord-005453-4057qib7 3855 51 n=10 n=10 NNP cord-005453-4057qib7 3855 52 , , , cord-005453-4057qib7 3855 53 83 83 CD cord-005453-4057qib7 3855 54 % % NN cord-005453-4057qib7 3855 55 ) ) -RRB- cord-005453-4057qib7 3855 56 . . . cord-005453-4057qib7 3856 1 Acute acute JJ cord-005453-4057qib7 3856 2 and and CC cord-005453-4057qib7 3856 3 chronic chronic JJ cord-005453-4057qib7 3856 4 GVHD GVHD NNP cord-005453-4057qib7 3856 5 were be VBD cord-005453-4057qib7 3856 6 present present JJ cord-005453-4057qib7 3856 7 in in IN cord-005453-4057qib7 3856 8 25 25 CD cord-005453-4057qib7 3856 9 % % NN cord-005453-4057qib7 3856 10 ( ( -LRB- cord-005453-4057qib7 3856 11 Grades grade NNS cord-005453-4057qib7 3856 12 I I NNP cord-005453-4057qib7 3856 13 - - HYPH cord-005453-4057qib7 3856 14 II II NNP cord-005453-4057qib7 3856 15 89 89 CD cord-005453-4057qib7 3856 16 % % NN cord-005453-4057qib7 3856 17 ) ) -RRB- cord-005453-4057qib7 3856 18 and and CC cord-005453-4057qib7 3856 19 35 35 CD cord-005453-4057qib7 3856 20 % % NN cord-005453-4057qib7 3856 21 ( ( -LRB- cord-005453-4057qib7 3856 22 limited limited JJ cord-005453-4057qib7 3856 23 76 76 CD cord-005453-4057qib7 3856 24 % % NN cord-005453-4057qib7 3856 25 ) ) -RRB- cord-005453-4057qib7 3856 26 , , , cord-005453-4057qib7 3856 27 respectively respectively RB cord-005453-4057qib7 3856 28 . . . cord-005453-4057qib7 3857 1 For for IN cord-005453-4057qib7 3857 2 allo allo NN cord-005453-4057qib7 3857 3 - - HYPH cord-005453-4057qib7 3857 4 HSCT HSCT NNP cord-005453-4057qib7 3857 5 , , , cord-005453-4057qib7 3857 6 30 30 CD cord-005453-4057qib7 3857 7 , , , cord-005453-4057qib7 3857 8 100day 100day CD cord-005453-4057qib7 3857 9 , , , cord-005453-4057qib7 3857 10 and and CC cord-005453-4057qib7 3857 11 1-year 1-year CD cord-005453-4057qib7 3857 12 NRM NRM NNP cord-005453-4057qib7 3857 13 was be VBD cord-005453-4057qib7 3857 14 2.5 2.5 CD cord-005453-4057qib7 3857 15 % % NN cord-005453-4057qib7 3857 16 , , , cord-005453-4057qib7 3857 17 8 8 CD cord-005453-4057qib7 3857 18 % % NN cord-005453-4057qib7 3857 19 , , , cord-005453-4057qib7 3857 20 and and CC cord-005453-4057qib7 3857 21 12 12 CD cord-005453-4057qib7 3857 22 % % NN cord-005453-4057qib7 3857 23 , , , cord-005453-4057qib7 3857 24 respectively respectively RB cord-005453-4057qib7 3857 25 ; ; : cord-005453-4057qib7 3857 26 30 30 CD cord-005453-4057qib7 3857 27 and and CC cord-005453-4057qib7 3857 28 100-day 100-day JJ cord-005453-4057qib7 3857 29 NRM NRM NNP cord-005453-4057qib7 3857 30 in in IN cord-005453-4057qib7 3857 31 auto auto NN cord-005453-4057qib7 3857 32 - - HYPH cord-005453-4057qib7 3857 33 HSCT HSCT NNP cord-005453-4057qib7 3857 34 was be VBD cord-005453-4057qib7 3857 35 1.5 1.5 CD cord-005453-4057qib7 3857 36 % % NN cord-005453-4057qib7 3857 37 ; ; , cord-005453-4057qib7 3857 38 10year 10year JJ cord-005453-4057qib7 3857 39 OS OS NNP cord-005453-4057qib7 3857 40 was be VBD cord-005453-4057qib7 3857 41 63 63 CD cord-005453-4057qib7 3857 42 % % NN cord-005453-4057qib7 3857 43 and and CC cord-005453-4057qib7 3857 44 56 56 CD cord-005453-4057qib7 3857 45 % % NN cord-005453-4057qib7 3857 46 for for IN cord-005453-4057qib7 3857 47 auto auto NN cord-005453-4057qib7 3857 48 and and CC cord-005453-4057qib7 3857 49 allo allo NN cord-005453-4057qib7 3857 50 - - HYPH cord-005453-4057qib7 3857 51 HSCT HSCT NNP cord-005453-4057qib7 3857 52 , , , cord-005453-4057qib7 3857 53 respectively respectively RB cord-005453-4057qib7 3857 54 . . . cord-005453-4057qib7 3858 1 Conclusions conclusion NNS cord-005453-4057qib7 3858 2 : : : cord-005453-4057qib7 3859 1 Future future JJ cord-005453-4057qib7 3859 2 perspectives perspective NNS cord-005453-4057qib7 3859 3 of of IN cord-005453-4057qib7 3859 4 the the DT cord-005453-4057qib7 3859 5 HSCT HSCT NNP cord-005453-4057qib7 3859 6 Program Program NNP cord-005453-4057qib7 3859 7 include include VBP cord-005453-4057qib7 3859 8 the the DT cord-005453-4057qib7 3859 9 acquisition acquisition NN cord-005453-4057qib7 3859 10 of of IN cord-005453-4057qib7 3859 11 funds fund NNS cord-005453-4057qib7 3859 12 for for IN cord-005453-4057qib7 3859 13 unrelated unrelated JJ cord-005453-4057qib7 3859 14 donors donor NNS cord-005453-4057qib7 3859 15 ; ; : cord-005453-4057qib7 3859 16 to to TO cord-005453-4057qib7 3859 17 improve improve VB cord-005453-4057qib7 3859 18 outcomes outcome NNS cord-005453-4057qib7 3859 19 of of IN cord-005453-4057qib7 3859 20 patients patient NNS cord-005453-4057qib7 3859 21 undergoing undergo VBG cord-005453-4057qib7 3859 22 haploidentical haploidentical JJ cord-005453-4057qib7 3859 23 HSCT HSCT NNP cord-005453-4057qib7 3859 24 , , , cord-005453-4057qib7 3859 25 and and CC cord-005453-4057qib7 3859 26 to to TO cord-005453-4057qib7 3859 27 increase increase VB cord-005453-4057qib7 3859 28 the the DT cord-005453-4057qib7 3859 29 number number NN cord-005453-4057qib7 3859 30 of of IN cord-005453-4057qib7 3859 31 in in IN cord-005453-4057qib7 3859 32 - - HYPH cord-005453-4057qib7 3859 33 patient patient NN cord-005453-4057qib7 3859 34 rooms room NNS cord-005453-4057qib7 3859 35 . . . cord-005453-4057qib7 3860 1 We -PRON- PRP cord-005453-4057qib7 3860 2 conclude conclude VBP cord-005453-4057qib7 3860 3 that that IN cord-005453-4057qib7 3860 4 despite despite IN cord-005453-4057qib7 3860 5 paucity paucity NN cord-005453-4057qib7 3860 6 of of IN cord-005453-4057qib7 3860 7 resources resource NNS cord-005453-4057qib7 3860 8 and and CC cord-005453-4057qib7 3860 9 other other JJ cord-005453-4057qib7 3860 10 limitations limitation NNS cord-005453-4057qib7 3860 11 , , , cord-005453-4057qib7 3860 12 the the DT cord-005453-4057qib7 3860 13 implementation implementation NN cord-005453-4057qib7 3860 14 of of IN cord-005453-4057qib7 3860 15 financial financial JJ cord-005453-4057qib7 3860 16 , , , cord-005453-4057qib7 3860 17 medical medical JJ cord-005453-4057qib7 3860 18 , , , cord-005453-4057qib7 3860 19 and and CC cord-005453-4057qib7 3860 20 research research NN cord-005453-4057qib7 3860 21 strategies strategy NNS cord-005453-4057qib7 3860 22 have have VBP cord-005453-4057qib7 3860 23 shown show VBN cord-005453-4057qib7 3860 24 that that IN cord-005453-4057qib7 3860 25 barriers barrier NNS cord-005453-4057qib7 3860 26 can can MD cord-005453-4057qib7 3860 27 be be VB cord-005453-4057qib7 3860 28 effectively effectively RB cord-005453-4057qib7 3860 29 overcome overcome VBN cord-005453-4057qib7 3860 30 in in IN cord-005453-4057qib7 3860 31 a a DT cord-005453-4057qib7 3860 32 developing develop VBG cord-005453-4057qib7 3860 33 country country NN cord-005453-4057qib7 3860 34 in in IN cord-005453-4057qib7 3860 35 order order NN cord-005453-4057qib7 3860 36 to to TO cord-005453-4057qib7 3860 37 establish establish VB cord-005453-4057qib7 3860 38 a a DT cord-005453-4057qib7 3860 39 consolidated consolidate VBN cord-005453-4057qib7 3860 40 and and CC cord-005453-4057qib7 3860 41 nationally nationally RB cord-005453-4057qib7 3860 42 renowned renowned JJ cord-005453-4057qib7 3860 43 HSCT HSCT NNP cord-005453-4057qib7 3860 44 Program Program NNP cord-005453-4057qib7 3860 45 , , , cord-005453-4057qib7 3860 46 providing provide VBG cord-005453-4057qib7 3860 47 good good JJ cord-005453-4057qib7 3860 48 outcomes outcome NNS cord-005453-4057qib7 3860 49 for for IN cord-005453-4057qib7 3860 50 patients patient NNS cord-005453-4057qib7 3860 51 . . . cord-005453-4057qib7 3861 1 Disclosure disclosure NN cord-005453-4057qib7 3861 2 : : : cord-005453-4057qib7 3861 3 None none NN cord-005453-4057qib7 3861 4 of of IN cord-005453-4057qib7 3861 5 the the DT cord-005453-4057qib7 3861 6 authors author NNS cord-005453-4057qib7 3861 7 have have VBP cord-005453-4057qib7 3861 8 any any DT cord-005453-4057qib7 3861 9 conflict conflict NN cord-005453-4057qib7 3861 10 of of IN cord-005453-4057qib7 3861 11 interest interest NN cord-005453-4057qib7 3861 12 to to TO cord-005453-4057qib7 3861 13 disclose disclose VB cord-005453-4057qib7 3861 14 . . . cord-005453-4057qib7 3862 1 The the DT cord-005453-4057qib7 3862 2 effect effect NN cord-005453-4057qib7 3862 3 of of IN cord-005453-4057qib7 3862 4 protective protective JJ cord-005453-4057qib7 3862 5 buffering buffering NN cord-005453-4057qib7 3862 6 on on IN cord-005453-4057qib7 3862 7 daily daily JJ cord-005453-4057qib7 3862 8 stress stress NN cord-005453-4057qib7 3862 9 and and CC cord-005453-4057qib7 3862 10 relationship relationship NN cord-005453-4057qib7 3862 11 quality quality NN cord-005453-4057qib7 3862 12 in in IN cord-005453-4057qib7 3862 13 dyads dyad NNS cord-005453-4057qib7 3862 14 following follow VBG cord-005453-4057qib7 3862 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 3862 16 stem stem NN cord-005453-4057qib7 3862 17 cell cell NN cord-005453-4057qib7 3862 18 transplantation transplantation NN cord-005453-4057qib7 3862 19 : : : cord-005453-4057qib7 3862 20 Results result NNS cord-005453-4057qib7 3862 21 from from IN cord-005453-4057qib7 3862 22 daily daily JJ cord-005453-4057qib7 3862 23 process process NN cord-005453-4057qib7 3862 24 methodology methodology NN cord-005453-4057qib7 3863 1 Malgorzata Malgorzata NNP cord-005453-4057qib7 3863 2 Sobczyk Sobczyk NNP cord-005453-4057qib7 3863 3 - - HYPH cord-005453-4057qib7 3863 4 Kruszelnicka Kruszelnicka NNP cord-005453-4057qib7 3863 5 1 1 CD cord-005453-4057qib7 3863 6 , , , cord-005453-4057qib7 3863 7 Aleksandra Aleksandra NNP cord-005453-4057qib7 3863 8 Kroemeke Kroemeke NNP cord-005453-4057qib7 3863 9 2 2 CD cord-005453-4057qib7 3863 10 , , , cord-005453-4057qib7 3863 11 Zuzanna Zuzanna NNP cord-005453-4057qib7 3863 12 Kwissa Kwissa NNP cord-005453-4057qib7 3863 13 - - HYPH cord-005453-4057qib7 3863 14 Gajewska Gajewska NNP cord-005453-4057qib7 3863 15 2 2 CD cord-005453-4057qib7 3863 16 , , , cord-005453-4057qib7 3863 17 Sebastian Sebastian NNP cord-005453-4057qib7 3863 18 Giebel Giebel NNP cord-005453-4057qib7 3863 19 1 1 CD cord-005453-4057qib7 3863 20 Background Background NNP cord-005453-4057qib7 3863 21 : : : cord-005453-4057qib7 3863 22 Cancer cancer NN cord-005453-4057qib7 3863 23 - - HYPH cord-005453-4057qib7 3863 24 related relate VBN cord-005453-4057qib7 3863 25 support support NN cord-005453-4057qib7 3863 26 communication communication NN cord-005453-4057qib7 3863 27 ( ( -LRB- cord-005453-4057qib7 3863 28 e.g. e.g. RB cord-005453-4057qib7 3863 29 , , , cord-005453-4057qib7 3863 30 protective protective JJ cord-005453-4057qib7 3863 31 buffering buffering NN cord-005453-4057qib7 3863 32 ) ) -RRB- cord-005453-4057qib7 3863 33 may may MD cord-005453-4057qib7 3863 34 impact impact VB cord-005453-4057qib7 3863 35 the the DT cord-005453-4057qib7 3863 36 risk risk NN cord-005453-4057qib7 3863 37 for for IN cord-005453-4057qib7 3863 38 psychological psychological JJ cord-005453-4057qib7 3863 39 and and CC cord-005453-4057qib7 3863 40 relationship relationship NN cord-005453-4057qib7 3863 41 distress distress NN cord-005453-4057qib7 3863 42 in in IN cord-005453-4057qib7 3863 43 patients patient NNS cord-005453-4057qib7 3863 44 following follow VBG cord-005453-4057qib7 3863 45 hematopoietic hematopoietic JJ cord-005453-4057qib7 3863 46 stem stem NN cord-005453-4057qib7 3863 47 cell cell NN cord-005453-4057qib7 3863 48 transplantation transplantation NN cord-005453-4057qib7 3863 49 ( ( -LRB- cord-005453-4057qib7 3863 50 HSCT HSCT NNP cord-005453-4057qib7 3863 51 ) ) -RRB- cord-005453-4057qib7 3863 52 and and CC cord-005453-4057qib7 3863 53 their -PRON- PRP$ cord-005453-4057qib7 3863 54 caregivers caregiver NNS cord-005453-4057qib7 3863 55 . . . cord-005453-4057qib7 3864 1 Previous previous JJ cord-005453-4057qib7 3864 2 studies study NNS cord-005453-4057qib7 3864 3 have have VBP cord-005453-4057qib7 3864 4 revealed reveal VBN cord-005453-4057qib7 3864 5 that that IN cord-005453-4057qib7 3864 6 protective protective JJ cord-005453-4057qib7 3864 7 buffering buffering NN cord-005453-4057qib7 3864 8 ( ( -LRB- cord-005453-4057qib7 3864 9 i.e. i.e. FW cord-005453-4057qib7 3864 10 , , , cord-005453-4057qib7 3864 11 hiding hide VBG cord-005453-4057qib7 3864 12 one one PRP cord-005453-4057qib7 3864 13 's 's POS cord-005453-4057qib7 3864 14 concerns concern NNS cord-005453-4057qib7 3864 15 and and CC cord-005453-4057qib7 3864 16 denying deny VBG cord-005453-4057qib7 3864 17 one one PRP cord-005453-4057qib7 3864 18 's 's POS cord-005453-4057qib7 3864 19 worries worry NNS cord-005453-4057qib7 3864 20 ) ) -RRB- cord-005453-4057qib7 3864 21 has have VBZ cord-005453-4057qib7 3864 22 mixed mix VBN cord-005453-4057qib7 3864 23 effects effect NNS cord-005453-4057qib7 3864 24 : : : cord-005453-4057qib7 3864 25 is be VBZ cord-005453-4057qib7 3864 26 beneficial beneficial JJ cord-005453-4057qib7 3864 27 ( ( -LRB- cord-005453-4057qib7 3864 28 for for IN cord-005453-4057qib7 3864 29 " " `` cord-005453-4057qib7 3864 30 protected protect VBN cord-005453-4057qib7 3864 31 " " '' cord-005453-4057qib7 3864 32 person person NN cord-005453-4057qib7 3864 33 ) ) -RRB- cord-005453-4057qib7 3864 34 , , , cord-005453-4057qib7 3864 35 costly costly JJ cord-005453-4057qib7 3864 36 ( ( -LRB- cord-005453-4057qib7 3864 37 especially especially RB cord-005453-4057qib7 3864 38 for for IN cord-005453-4057qib7 3864 39 the the DT cord-005453-4057qib7 3864 40 person person NN cord-005453-4057qib7 3864 41 using use VBG cord-005453-4057qib7 3864 42 it -PRON- PRP cord-005453-4057qib7 3864 43 ) ) -RRB- cord-005453-4057qib7 3864 44 , , , cord-005453-4057qib7 3864 45 or or CC cord-005453-4057qib7 3864 46 unrelated unrelated JJ cord-005453-4057qib7 3864 47 to to IN cord-005453-4057qib7 3864 48 dyadic dyadic JJ cord-005453-4057qib7 3864 49 wellbeing wellbeing NN cord-005453-4057qib7 3864 50 . . . cord-005453-4057qib7 3865 1 There there EX cord-005453-4057qib7 3865 2 has have VBZ cord-005453-4057qib7 3865 3 been be VBN cord-005453-4057qib7 3865 4 , , , cord-005453-4057qib7 3865 5 however however RB cord-005453-4057qib7 3865 6 , , , cord-005453-4057qib7 3865 7 little little JJ cord-005453-4057qib7 3865 8 evidence evidence NN cord-005453-4057qib7 3865 9 linking link VBG cord-005453-4057qib7 3865 10 dyadic dyadic JJ cord-005453-4057qib7 3865 11 protective protective JJ cord-005453-4057qib7 3865 12 buffering buffering NN cord-005453-4057qib7 3865 13 with with IN cord-005453-4057qib7 3865 14 distress distress NN cord-005453-4057qib7 3865 15 using use VBG cord-005453-4057qib7 3865 16 daily daily JJ cord-005453-4057qib7 3865 17 process process NN cord-005453-4057qib7 3865 18 methodology methodology NN cord-005453-4057qib7 3865 19 . . . cord-005453-4057qib7 3866 1 We -PRON- PRP cord-005453-4057qib7 3866 2 assessed assess VBD cord-005453-4057qib7 3866 3 ( ( -LRB- cord-005453-4057qib7 3866 4 1 1 CD cord-005453-4057qib7 3866 5 ) ) -RRB- cord-005453-4057qib7 3866 6 the the DT cord-005453-4057qib7 3866 7 relationship relationship NN cord-005453-4057qib7 3866 8 between between IN cord-005453-4057qib7 3866 9 daily daily JJ cord-005453-4057qib7 3866 10 protective protective JJ cord-005453-4057qib7 3866 11 buffering buffering NN cord-005453-4057qib7 3866 12 , , , cord-005453-4057qib7 3866 13 and and CC cord-005453-4057qib7 3866 14 same same JJ cord-005453-4057qib7 3866 15 - - : cord-005453-4057qib7 3866 16 and and CC cord-005453-4057qib7 3866 17 next next JJ cord-005453-4057qib7 3866 18 - - HYPH cord-005453-4057qib7 3866 19 day day NN cord-005453-4057qib7 3866 20 stress stress NN cord-005453-4057qib7 3866 21 and and CC cord-005453-4057qib7 3866 22 relationship relationship NN cord-005453-4057qib7 3866 23 quality quality NN cord-005453-4057qib7 3866 24 in in IN cord-005453-4057qib7 3866 25 patient patient NN cord-005453-4057qib7 3866 26 - - HYPH cord-005453-4057qib7 3866 27 caregiver caregiver NN cord-005453-4057qib7 3866 28 dyads dyad NNS cord-005453-4057qib7 3866 29 following follow VBG cord-005453-4057qib7 3866 30 HSCT HSCT NNP cord-005453-4057qib7 3866 31 and and CC cord-005453-4057qib7 3866 32 ( ( -LRB- cord-005453-4057qib7 3866 33 2 2 LS cord-005453-4057qib7 3866 34 ) ) -RRB- cord-005453-4057qib7 3867 1 whether whether IN cord-005453-4057qib7 3867 2 similarity similarity NN cord-005453-4057qib7 3867 3 or or CC cord-005453-4057qib7 3867 4 complementarity complementarity NN cord-005453-4057qib7 3867 5 in in IN cord-005453-4057qib7 3867 6 protective protective JJ cord-005453-4057qib7 3867 7 buffering buffering NN cord-005453-4057qib7 3867 8 between between IN cord-005453-4057qib7 3867 9 dyads dyad NNS cord-005453-4057qib7 3867 10 is be VBZ cord-005453-4057qib7 3867 11 adaptive adaptive JJ cord-005453-4057qib7 3867 12 . . . cord-005453-4057qib7 3868 1 Methods method NNS cord-005453-4057qib7 3868 2 : : : cord-005453-4057qib7 3869 1 Two two CD cord-005453-4057qib7 3869 2 hundred hundred CD cord-005453-4057qib7 3869 3 patients patient NNS cord-005453-4057qib7 3869 4 ( ( -LRB- cord-005453-4057qib7 3869 5 after after IN cord-005453-4057qib7 3869 6 first first JJ cord-005453-4057qib7 3869 7 autologous autologous JJ cord-005453-4057qib7 3869 8 or or CC cord-005453-4057qib7 3869 9 allogeneic allogeneic IN cord-005453-4057qib7 3869 10 HSCT HSCT NNP cord-005453-4057qib7 3869 11 ) ) -RRB- cord-005453-4057qib7 3869 12 and and CC cord-005453-4057qib7 3869 13 their -PRON- PRP$ cord-005453-4057qib7 3869 14 caregivers caregiver NNS cord-005453-4057qib7 3869 15 ( ( -LRB- cord-005453-4057qib7 3869 16 spouse spouse NN cord-005453-4057qib7 3869 17 or or CC cord-005453-4057qib7 3869 18 another another DT cord-005453-4057qib7 3869 19 relative relative NN cord-005453-4057qib7 3869 20 ) ) -RRB- cord-005453-4057qib7 3869 21 independently independently RB cord-005453-4057qib7 3869 22 completed complete VBN cord-005453-4057qib7 3869 23 measures measure NNS cord-005453-4057qib7 3869 24 of of IN cord-005453-4057qib7 3869 25 daily daily JJ cord-005453-4057qib7 3869 26 protective protective JJ cord-005453-4057qib7 3869 27 buffering buffering NN cord-005453-4057qib7 3869 28 , , , cord-005453-4057qib7 3869 29 daily daily JJ cord-005453-4057qib7 3869 30 relationship relationship NN cord-005453-4057qib7 3869 31 quality quality NN cord-005453-4057qib7 3869 32 , , , cord-005453-4057qib7 3869 33 and and CC cord-005453-4057qib7 3869 34 daily daily JJ cord-005453-4057qib7 3869 35 stress stress NN cord-005453-4057qib7 3869 36 for for IN cord-005453-4057qib7 3869 37 28 28 CD cord-005453-4057qib7 3869 38 consecutive consecutive JJ cord-005453-4057qib7 3869 39 evenings evening NNS cord-005453-4057qib7 3869 40 after after IN cord-005453-4057qib7 3869 41 patients´hospital patients´hospital NNP cord-005453-4057qib7 3869 42 discharge discharge NN cord-005453-4057qib7 3869 43 . . . cord-005453-4057qib7 3870 1 Actor Actor NNP cord-005453-4057qib7 3870 2 - - HYPH cord-005453-4057qib7 3870 3 Partner Partner NNP cord-005453-4057qib7 3870 4 - - HYPH cord-005453-4057qib7 3870 5 Interdependence Interdependence NNP cord-005453-4057qib7 3870 6 Model Model NNP cord-005453-4057qib7 3870 7 ( ( -LRB- cord-005453-4057qib7 3870 8 i.e. i.e. FW cord-005453-4057qib7 3870 9 , , , cord-005453-4057qib7 3870 10 both both DT cord-005453-4057qib7 3870 11 partners partner NNS cord-005453-4057qib7 3870 12 ' ' POS cord-005453-4057qib7 3870 13 and and CC cord-005453-4057qib7 3870 14 caregivers caregiver NNS cord-005453-4057qib7 3870 15 ' ' POS cord-005453-4057qib7 3870 16 reports report NNS cord-005453-4057qib7 3870 17 regarding regard VBG cord-005453-4057qib7 3870 18 support support NN cord-005453-4057qib7 3870 19 communication communication NN cord-005453-4057qib7 3870 20 and and CC cord-005453-4057qib7 3870 21 distress distress NN cord-005453-4057qib7 3870 22 were be VBD cord-005453-4057qib7 3870 23 studied study VBN cord-005453-4057qib7 3870 24 ) ) -RRB- cord-005453-4057qib7 3870 25 was be VBD cord-005453-4057qib7 3870 26 used use VBN cord-005453-4057qib7 3870 27 to to TO cord-005453-4057qib7 3870 28 test test VB cord-005453-4057qib7 3870 29 study study NN cord-005453-4057qib7 3870 30 hypotheses hypothesis NNS cord-005453-4057qib7 3870 31 . . . cord-005453-4057qib7 3871 1 Results result NNS cord-005453-4057qib7 3871 2 : : : cord-005453-4057qib7 3872 1 For for IN cord-005453-4057qib7 3872 2 both both DT cord-005453-4057qib7 3872 3 patients patient NNS cord-005453-4057qib7 3872 4 and and CC cord-005453-4057qib7 3872 5 caregivers caregiver NNS cord-005453-4057qib7 3872 6 , , , cord-005453-4057qib7 3872 7 multilevel multilevel JJ cord-005453-4057qib7 3872 8 structural structural JJ cord-005453-4057qib7 3872 9 equation equation NN cord-005453-4057qib7 3872 10 modeling modeling NN cord-005453-4057qib7 3872 11 showed show VBD cord-005453-4057qib7 3872 12 a a DT cord-005453-4057qib7 3872 13 significant significant JJ cord-005453-4057qib7 3872 14 positive positive JJ cord-005453-4057qib7 3872 15 relationship relationship NN cord-005453-4057qib7 3872 16 between between IN cord-005453-4057qib7 3872 17 daily daily JJ cord-005453-4057qib7 3872 18 protective protective JJ cord-005453-4057qib7 3872 19 buffering buffering NN cord-005453-4057qib7 3872 20 and and CC cord-005453-4057qib7 3872 21 sameday sameday NN cord-005453-4057qib7 3872 22 relationship relationship NN cord-005453-4057qib7 3872 23 quality quality NN cord-005453-4057qib7 3872 24 . . . cord-005453-4057qib7 3873 1 Association Association NNP cord-005453-4057qib7 3873 2 of of IN cord-005453-4057qib7 3873 3 protective protective JJ cord-005453-4057qib7 3873 4 buffering buffering NN cord-005453-4057qib7 3873 5 with with IN cord-005453-4057qib7 3873 6 same same JJ cord-005453-4057qib7 3873 7 - - HYPH cord-005453-4057qib7 3873 8 day day NN cord-005453-4057qib7 3873 9 stress stress NN cord-005453-4057qib7 3873 10 level level NN cord-005453-4057qib7 3873 11 was be VBD cord-005453-4057qib7 3873 12 negative negative JJ cord-005453-4057qib7 3873 13 . . . cord-005453-4057qib7 3874 1 In in IN cord-005453-4057qib7 3874 2 next next JJ cord-005453-4057qib7 3874 3 - - HYPH cord-005453-4057qib7 3874 4 day day NN cord-005453-4057qib7 3874 5 analyses analysis NNS cord-005453-4057qib7 3874 6 , , , cord-005453-4057qib7 3874 7 patient patient NN cord-005453-4057qib7 3874 8 - - HYPH cord-005453-4057qib7 3874 9 reported report VBN cord-005453-4057qib7 3874 10 protective protective JJ cord-005453-4057qib7 3874 11 buffering buffering NN cord-005453-4057qib7 3874 12 was be VBD cord-005453-4057qib7 3874 13 related relate VBN cord-005453-4057qib7 3874 14 to to IN cord-005453-4057qib7 3874 15 patient patient NN cord-005453-4057qib7 3874 16 's 's POS cord-005453-4057qib7 3874 17 higher high JJR cord-005453-4057qib7 3874 18 relationship relationship NN cord-005453-4057qib7 3874 19 quality quality NN cord-005453-4057qib7 3874 20 , , , cord-005453-4057qib7 3874 21 whereas whereas IN cord-005453-4057qib7 3874 22 caregiverreported caregiverreported JJ cord-005453-4057qib7 3874 23 protective protective JJ cord-005453-4057qib7 3874 24 buffering buffering NN cord-005453-4057qib7 3874 25 increased increase VBN cord-005453-4057qib7 3874 26 patient patient NN cord-005453-4057qib7 3874 27 's 's POS cord-005453-4057qib7 3874 28 daily daily JJ cord-005453-4057qib7 3874 29 stress stress NN cord-005453-4057qib7 3874 30 . . . cord-005453-4057qib7 3875 1 Complementarity complementarity NN cord-005453-4057qib7 3875 2 in in IN cord-005453-4057qib7 3875 3 protective protective JJ cord-005453-4057qib7 3875 4 buffering buffering NN cord-005453-4057qib7 3875 5 was be VBD cord-005453-4057qib7 3875 6 related relate VBN cord-005453-4057qib7 3875 7 to to IN cord-005453-4057qib7 3875 8 higher high JJR cord-005453-4057qib7 3875 9 immediate immediate JJ cord-005453-4057qib7 3875 10 same same JJ cord-005453-4057qib7 3875 11 - - HYPH cord-005453-4057qib7 3875 12 day day NN cord-005453-4057qib7 3875 13 relationship relationship NN cord-005453-4057qib7 3875 14 quality quality NN cord-005453-4057qib7 3875 15 for for IN cord-005453-4057qib7 3875 16 both both DT cord-005453-4057qib7 3875 17 patients patient NNS cord-005453-4057qib7 3875 18 and and CC cord-005453-4057qib7 3875 19 caregivers caregiver NNS cord-005453-4057qib7 3875 20 , , , cord-005453-4057qib7 3875 21 while while IN cord-005453-4057qib7 3875 22 benefits benefit NNS cord-005453-4057qib7 3875 23 from from IN cord-005453-4057qib7 3875 24 similarity similarity NN cord-005453-4057qib7 3875 25 have have VBP cord-005453-4057qib7 3875 26 delayed delay VBN cord-005453-4057qib7 3875 27 effects effect NNS cord-005453-4057qib7 3875 28 , , , cord-005453-4057qib7 3875 29 although although IN cord-005453-4057qib7 3875 30 only only RB cord-005453-4057qib7 3875 31 in in IN cord-005453-4057qib7 3875 32 patients patient NNS cord-005453-4057qib7 3875 33 . . . cord-005453-4057qib7 3876 1 Conclusions conclusion NNS cord-005453-4057qib7 3876 2 : : : cord-005453-4057qib7 3877 1 Contrary contrary JJ cord-005453-4057qib7 3877 2 to to IN cord-005453-4057qib7 3877 3 previous previous JJ cord-005453-4057qib7 3877 4 studies study NNS cord-005453-4057qib7 3877 5 , , , cord-005453-4057qib7 3877 6 protective protective JJ cord-005453-4057qib7 3877 7 buffering buffering NN cord-005453-4057qib7 3877 8 rather rather RB cord-005453-4057qib7 3877 9 has have VBZ cord-005453-4057qib7 3877 10 a a DT cord-005453-4057qib7 3877 11 beneficial beneficial JJ cord-005453-4057qib7 3877 12 effect effect NN cord-005453-4057qib7 3877 13 in in IN cord-005453-4057qib7 3877 14 dyads dyad NNS cord-005453-4057qib7 3877 15 following follow VBG cord-005453-4057qib7 3877 16 HSCT HSCT NNP cord-005453-4057qib7 3877 17 . . . cord-005453-4057qib7 3878 1 Protection protection NN cord-005453-4057qib7 3878 2 of of IN cord-005453-4057qib7 3878 3 the the DT cord-005453-4057qib7 3878 4 partner partner NN cord-005453-4057qib7 3878 5 and and CC cord-005453-4057qib7 3878 6 relationship relationship NN cord-005453-4057qib7 3878 7 against against IN cord-005453-4057qib7 3878 8 revealing reveal VBG cord-005453-4057qib7 3878 9 negative negative JJ cord-005453-4057qib7 3878 10 emotions emotion NNS cord-005453-4057qib7 3878 11 and and CC cord-005453-4057qib7 3878 12 powerlessness powerlessness NN cord-005453-4057qib7 3878 13 was be VBD cord-005453-4057qib7 3878 14 not not RB cord-005453-4057qib7 3878 15 related relate VBN cord-005453-4057qib7 3878 16 to to IN cord-005453-4057qib7 3878 17 costs cost NNS cord-005453-4057qib7 3878 18 in in IN cord-005453-4057qib7 3878 19 both both DT cord-005453-4057qib7 3878 20 parties party NNS cord-005453-4057qib7 3878 21 . . . cord-005453-4057qib7 3879 1 The the DT cord-005453-4057qib7 3879 2 findings finding NNS cord-005453-4057qib7 3879 3 suggest suggest VBP cord-005453-4057qib7 3879 4 that that IN cord-005453-4057qib7 3879 5 the the DT cord-005453-4057qib7 3879 6 effect effect NN cord-005453-4057qib7 3879 7 of of IN cord-005453-4057qib7 3879 8 daily daily JJ cord-005453-4057qib7 3879 9 protective protective JJ cord-005453-4057qib7 3879 10 buffering buffering NN cord-005453-4057qib7 3879 11 in in IN cord-005453-4057qib7 3879 12 dyads dyad NNS cord-005453-4057qib7 3879 13 following follow VBG cord-005453-4057qib7 3879 14 HSCT HSCT NNP cord-005453-4057qib7 3879 15 depends depend VBZ cord-005453-4057qib7 3879 16 on on IN cord-005453-4057qib7 3879 17 support support NN cord-005453-4057qib7 3879 18 timing timing NN cord-005453-4057qib7 3879 19 ( ( -LRB- cord-005453-4057qib7 3879 20 same same JJ cord-005453-4057qib7 3879 21 - - : cord-005453-4057qib7 3879 22 or or CC cord-005453-4057qib7 3879 23 next next JJ cord-005453-4057qib7 3879 24 - - HYPH cord-005453-4057qib7 3879 25 day day NN cord-005453-4057qib7 3879 26 effect effect NN cord-005453-4057qib7 3879 27 ) ) -RRB- cord-005453-4057qib7 3879 28 and and CC cord-005453-4057qib7 3879 29 differs differ VBZ cord-005453-4057qib7 3879 30 for for IN cord-005453-4057qib7 3879 31 both both DT cord-005453-4057qib7 3879 32 parties party NNS cord-005453-4057qib7 3879 33 . . . cord-005453-4057qib7 3880 1 Patients patient NNS cord-005453-4057qib7 3880 2 seem seem VBP cord-005453-4057qib7 3880 3 to to TO cord-005453-4057qib7 3880 4 benefit benefit VB cord-005453-4057qib7 3880 5 the the DT cord-005453-4057qib7 3880 6 most most JJS cord-005453-4057qib7 3880 7 from from IN cord-005453-4057qib7 3880 8 the the DT cord-005453-4057qib7 3880 9 similarity similarity NN cord-005453-4057qib7 3880 10 in in IN cord-005453-4057qib7 3880 11 protective protective JJ cord-005453-4057qib7 3880 12 buffering buffering NN cord-005453-4057qib7 3880 13 , , , cord-005453-4057qib7 3880 14 while while IN cord-005453-4057qib7 3880 15 caregivers caregiver NNS cord-005453-4057qib7 3880 16 from from IN cord-005453-4057qib7 3880 17 complementarity complementarity NN cord-005453-4057qib7 3880 18 . . . cord-005453-4057qib7 3881 1 The the DT cord-005453-4057qib7 3881 2 " " `` cord-005453-4057qib7 3881 3 fit fit JJ cord-005453-4057qib7 3881 4 " " '' cord-005453-4057qib7 3881 5 between between IN cord-005453-4057qib7 3881 6 patient patient NN cord-005453-4057qib7 3881 7 and and CC cord-005453-4057qib7 3881 8 caregiver caregiver NN cord-005453-4057qib7 3881 9 in in IN cord-005453-4057qib7 3881 10 support support NN cord-005453-4057qib7 3881 11 communication communication NN cord-005453-4057qib7 3881 12 ought ought MD cord-005453-4057qib7 3881 13 to to TO cord-005453-4057qib7 3881 14 be be VB cord-005453-4057qib7 3881 15 taken take VBN cord-005453-4057qib7 3881 16 into into IN cord-005453-4057qib7 3881 17 consideration consideration NN cord-005453-4057qib7 3881 18 in in IN cord-005453-4057qib7 3881 19 the the DT cord-005453-4057qib7 3881 20 practical practical JJ cord-005453-4057qib7 3881 21 approach approach NN cord-005453-4057qib7 3881 22 . . . cord-005453-4057qib7 3882 1 Disclosure disclosure NN cord-005453-4057qib7 3882 2 : : : cord-005453-4057qib7 3882 3 Nothing nothing NN cord-005453-4057qib7 3882 4 to to TO cord-005453-4057qib7 3882 5 declare declare VB cord-005453-4057qib7 3882 6 . . . cord-005453-4057qib7 3883 1 Virus virus NN cord-005453-4057qib7 3883 2 reactivation reactivation NN cord-005453-4057qib7 3883 3 and and CC cord-005453-4057qib7 3883 4 low low JJ cord-005453-4057qib7 3883 5 dose dose NN cord-005453-4057qib7 3883 6 of of IN cord-005453-4057qib7 3883 7 CD34 CD34 NNP cord-005453-4057qib7 3883 8 + + CC cord-005453-4057qib7 3883 9 cell cell NN cord-005453-4057qib7 3883 10 were be VBD cord-005453-4057qib7 3883 11 associatied associatie VBN cord-005453-4057qib7 3883 12 with with IN cord-005453-4057qib7 3883 13 secondary secondary JJ cord-005453-4057qib7 3883 14 poor poor JJ cord-005453-4057qib7 3883 15 graft graft NN cord-005453-4057qib7 3883 16 function function NN cord-005453-4057qib7 3883 17 within within IN cord-005453-4057qib7 3883 18 the the DT cord-005453-4057qib7 3883 19 first first JJ cord-005453-4057qib7 3883 20 100 100 CD cord-005453-4057qib7 3883 21 days day NNS cord-005453-4057qib7 3883 22 after after IN cord-005453-4057qib7 3883 23 allogeneic allogeneic NN cord-005453-4057qib7 3883 24 stem stem NN cord-005453-4057qib7 3883 25 cell cell NN cord-005453-4057qib7 3883 26 transplantation transplantation NN cord-005453-4057qib7 3884 1 Yuqian Yuqian NNP cord-005453-4057qib7 3884 2 Sun Sun NNP cord-005453-4057qib7 3884 3 1 1 CD cord-005453-4057qib7 3884 4 , , , cord-005453-4057qib7 3884 5 Xiao Xiao NNP cord-005453-4057qib7 3884 6 - - HYPH cord-005453-4057qib7 3884 7 Jun Jun NNP cord-005453-4057qib7 3884 8 Huang Huang NNP cord-005453-4057qib7 3884 9 1 1 CD cord-005453-4057qib7 3884 10 Background Background NNP cord-005453-4057qib7 3884 11 : : : cord-005453-4057qib7 3884 12 Secondary secondary JJ cord-005453-4057qib7 3884 13 poof poof NN cord-005453-4057qib7 3884 14 graft graft NN cord-005453-4057qib7 3884 15 function function NN cord-005453-4057qib7 3884 16 ( ( -LRB- cord-005453-4057qib7 3884 17 sPGF spgf FW cord-005453-4057qib7 3884 18 ) ) -RRB- cord-005453-4057qib7 3884 19 was be VBD cord-005453-4057qib7 3884 20 defined define VBN cord-005453-4057qib7 3884 21 as as IN cord-005453-4057qib7 3884 22 the the DT cord-005453-4057qib7 3884 23 secondary secondary JJ cord-005453-4057qib7 3884 24 cytopenia cytopenia NNS cord-005453-4057qib7 3884 25 after after IN cord-005453-4057qib7 3884 26 initial initial JJ cord-005453-4057qib7 3884 27 engraftment engraftment NN cord-005453-4057qib7 3884 28 of of IN cord-005453-4057qib7 3884 29 HSCT HSCT NNP cord-005453-4057qib7 3884 30 . . . cord-005453-4057qib7 3885 1 It -PRON- PRP cord-005453-4057qib7 3885 2 was be VBD cord-005453-4057qib7 3885 3 shown show VBN cord-005453-4057qib7 3885 4 to to TO cord-005453-4057qib7 3885 5 be be VB cord-005453-4057qib7 3885 6 associated associate VBN cord-005453-4057qib7 3885 7 with with IN cord-005453-4057qib7 3885 8 poor poor JJ cord-005453-4057qib7 3885 9 prognosis prognosis NN cord-005453-4057qib7 3885 10 , , , cord-005453-4057qib7 3885 11 however however RB cord-005453-4057qib7 3885 12 there there EX cord-005453-4057qib7 3885 13 are be VBP cord-005453-4057qib7 3885 14 very very RB cord-005453-4057qib7 3885 15 few few JJ cord-005453-4057qib7 3885 16 reports report NNS cord-005453-4057qib7 3885 17 on on IN cord-005453-4057qib7 3885 18 the the DT cord-005453-4057qib7 3885 19 incidence incidence NN cord-005453-4057qib7 3885 20 , , , cord-005453-4057qib7 3885 21 risk risk NN cord-005453-4057qib7 3885 22 factors factor NNS cord-005453-4057qib7 3885 23 and and CC cord-005453-4057qib7 3885 24 outcomes outcome NNS cord-005453-4057qib7 3885 25 of of IN cord-005453-4057qib7 3885 26 sPGF spgf FW cord-005453-4057qib7 3885 27 . . . cord-005453-4057qib7 3886 1 Methods method NNS cord-005453-4057qib7 3886 2 : : : cord-005453-4057qib7 3887 1 Patients patient NNS cord-005453-4057qib7 3887 2 who who WP cord-005453-4057qib7 3887 3 received receive VBD cord-005453-4057qib7 3887 4 transplantation transplantation NN cord-005453-4057qib7 3887 5 from from IN cord-005453-4057qib7 3887 6 Peking Peking NNP cord-005453-4057qib7 3887 7 University University NNP cord-005453-4057qib7 3887 8 People People NNPS cord-005453-4057qib7 3887 9 's 's POS cord-005453-4057qib7 3887 10 Hospitial Hospitial NNP cord-005453-4057qib7 3887 11 during during IN cord-005453-4057qib7 3887 12 January January NNP cord-005453-4057qib7 3887 13 , , , cord-005453-4057qib7 3887 14 2015 2015 CD cord-005453-4057qib7 3887 15 to to IN cord-005453-4057qib7 3887 16 December December NNP cord-005453-4057qib7 3887 17 , , , cord-005453-4057qib7 3887 18 2015 2015 CD cord-005453-4057qib7 3887 19 were be VBD cord-005453-4057qib7 3887 20 retrospectively retrospectively RB cord-005453-4057qib7 3887 21 reviewed review VBN cord-005453-4057qib7 3887 22 if if IN cord-005453-4057qib7 3887 23 they -PRON- PRP cord-005453-4057qib7 3887 24 fulfilled fulfil VBD cord-005453-4057qib7 3887 25 the the DT cord-005453-4057qib7 3887 26 following follow VBG cord-005453-4057qib7 3887 27 conditions condition NNS cord-005453-4057qib7 3887 28 : : : cord-005453-4057qib7 3887 29 ( ( -LRB- cord-005453-4057qib7 3887 30 1 1 LS cord-005453-4057qib7 3887 31 ) ) -RRB- cord-005453-4057qib7 3887 32 diagnosed diagnose VBN cord-005453-4057qib7 3887 33 with with IN cord-005453-4057qib7 3887 34 acute acute JJ cord-005453-4057qib7 3887 35 leukemia leukemia NN cord-005453-4057qib7 3887 36 or or CC cord-005453-4057qib7 3887 37 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 3887 38 syndrome syndrome NN cord-005453-4057qib7 3887 39 ; ; : cord-005453-4057qib7 3887 40 ( ( -LRB- cord-005453-4057qib7 3887 41 2 2 LS cord-005453-4057qib7 3887 42 ) ) -RRB- cord-005453-4057qib7 3887 43 received receive VBD cord-005453-4057qib7 3887 44 allo allo NN cord-005453-4057qib7 3887 45 - - HYPH cord-005453-4057qib7 3887 46 SCT SCT NNP cord-005453-4057qib7 3887 47 from from IN cord-005453-4057qib7 3887 48 either either CC cord-005453-4057qib7 3887 49 matched match VBN cord-005453-4057qib7 3887 50 sibling sibling NN cord-005453-4057qib7 3887 51 donor donor NN cord-005453-4057qib7 3887 52 ( ( -LRB- cord-005453-4057qib7 3887 53 MSD MSD NNP cord-005453-4057qib7 3887 54 ) ) -RRB- cord-005453-4057qib7 3887 55 or or CC cord-005453-4057qib7 3887 56 haploidentical haploidentical JJ cord-005453-4057qib7 3887 57 related related JJ cord-005453-4057qib7 3887 58 donor donor NN cord-005453-4057qib7 3887 59 ( ( -LRB- cord-005453-4057qib7 3887 60 HID HID NNP cord-005453-4057qib7 3887 61 ) ) -RRB- cord-005453-4057qib7 3887 62 . . . cord-005453-4057qib7 3888 1 PGF PGF NNP cord-005453-4057qib7 3888 2 was be VBD cord-005453-4057qib7 3888 3 defined define VBN cord-005453-4057qib7 3888 4 as as IN cord-005453-4057qib7 3888 5 persistent persistent JJ cord-005453-4057qib7 3888 6 neutropenia neutropenia NN cord-005453-4057qib7 3888 7 ( ( -LRB- cord-005453-4057qib7 3888 8 ≤0.5×10 ≤0.5×10 NNP cord-005453-4057qib7 3888 9 9 9 CD cord-005453-4057qib7 3888 10 /L /L . cord-005453-4057qib7 3888 11 ) ) -RRB- cord-005453-4057qib7 3888 12 , , , cord-005453-4057qib7 3888 13 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 3888 14 ( ( -LRB- cord-005453-4057qib7 3888 15 platelets platelet NNS cord-005453-4057qib7 3888 16 ≤20×10 ≤20×10 VBD cord-005453-4057qib7 3888 17 9 9 CD cord-005453-4057qib7 3888 18 /L /L . cord-005453-4057qib7 3888 19 ) ) -RRB- cord-005453-4057qib7 3888 20 , , , cord-005453-4057qib7 3888 21 and/or and/or CC cord-005453-4057qib7 3888 22 hemoglobin hemoglobin NN cord-005453-4057qib7 3888 23 ≤70 ≤70 : cord-005453-4057qib7 3888 24 g g NN cord-005453-4057qib7 3888 25 / / SYM cord-005453-4057qib7 3888 26 L l NN cord-005453-4057qib7 3888 27 for for IN cord-005453-4057qib7 3888 28 at at RB cord-005453-4057qib7 3888 29 least least JJS cord-005453-4057qib7 3888 30 3 3 CD cord-005453-4057qib7 3888 31 consecutive consecutive JJ cord-005453-4057qib7 3888 32 days day NNS cord-005453-4057qib7 3888 33 , , , cord-005453-4057qib7 3888 34 transfusion transfusion NN cord-005453-4057qib7 3888 35 - - HYPH cord-005453-4057qib7 3888 36 dependence dependence NN cord-005453-4057qib7 3888 37 , , , cord-005453-4057qib7 3888 38 associated associate VBN cord-005453-4057qib7 3888 39 with with IN cord-005453-4057qib7 3888 40 hypoplastic hypoplastic JJ cord-005453-4057qib7 3888 41 - - HYPH cord-005453-4057qib7 3888 42 aplastic aplastic NN cord-005453-4057qib7 3888 43 bone bone NN cord-005453-4057qib7 3888 44 marrow marrow NN cord-005453-4057qib7 3888 45 ( ( -LRB- cord-005453-4057qib7 3888 46 BM BM NNP cord-005453-4057qib7 3888 47 ) ) -RRB- cord-005453-4057qib7 3888 48 , , , cord-005453-4057qib7 3888 49 and and CC cord-005453-4057qib7 3888 50 complete complete JJ cord-005453-4057qib7 3888 51 donor donor NN cord-005453-4057qib7 3888 52 chimerism chimerism NN cord-005453-4057qib7 3888 53 without without IN cord-005453-4057qib7 3888 54 concurrent concurrent JJ cord-005453-4057qib7 3888 55 graftversus graftversus NN cord-005453-4057qib7 3888 56 - - HYPH cord-005453-4057qib7 3888 57 host host NN cord-005453-4057qib7 3888 58 disease disease NN cord-005453-4057qib7 3888 59 ( ( -LRB- cord-005453-4057qib7 3888 60 GVHD GVHD NNP cord-005453-4057qib7 3888 61 ) ) -RRB- cord-005453-4057qib7 3888 62 or or CC cord-005453-4057qib7 3888 63 disease disease NN cord-005453-4057qib7 3888 64 relapse relapse NN cord-005453-4057qib7 3888 65 . . . cord-005453-4057qib7 3889 1 Primary Primary NNP cord-005453-4057qib7 3889 2 PGF PGF NNP cord-005453-4057qib7 3889 3 was be VBD cord-005453-4057qib7 3889 4 defined define VBN cord-005453-4057qib7 3889 5 as as IN cord-005453-4057qib7 3889 6 the the DT cord-005453-4057qib7 3889 7 failure failure NN cord-005453-4057qib7 3889 8 to to TO cord-005453-4057qib7 3889 9 achieve achieve VB cord-005453-4057qib7 3889 10 initial initial JJ cord-005453-4057qib7 3889 11 engraftment engraftment NN cord-005453-4057qib7 3889 12 by by IN cord-005453-4057qib7 3889 13 days day NNS cord-005453-4057qib7 3889 14 28 28 CD cord-005453-4057qib7 3889 15 after after IN cord-005453-4057qib7 3889 16 transplantation transplantation NN cord-005453-4057qib7 3889 17 , , , cord-005453-4057qib7 3889 18 while while IN cord-005453-4057qib7 3889 19 secondary secondary JJ cord-005453-4057qib7 3889 20 PGF PGF NNP cord-005453-4057qib7 3889 21 was be VBD cord-005453-4057qib7 3889 22 defined define VBN cord-005453-4057qib7 3889 23 as as IN cord-005453-4057qib7 3889 24 the the DT cord-005453-4057qib7 3889 25 fulfillment fulfillment NN cord-005453-4057qib7 3889 26 of of IN cord-005453-4057qib7 3889 27 the the DT cord-005453-4057qib7 3889 28 criteria criterion NNS cord-005453-4057qib7 3889 29 after after IN cord-005453-4057qib7 3889 30 initial initial JJ cord-005453-4057qib7 3889 31 engraftment engraftment NN cord-005453-4057qib7 3889 32 HSCT HSCT NNP cord-005453-4057qib7 3889 33 . . . cord-005453-4057qib7 3890 1 Results result NNS cord-005453-4057qib7 3890 2 : : : cord-005453-4057qib7 3891 1 During during IN cord-005453-4057qib7 3891 2 January January NNP cord-005453-4057qib7 3891 3 , , , cord-005453-4057qib7 3891 4 2015 2015 CD cord-005453-4057qib7 3891 5 to to IN cord-005453-4057qib7 3891 6 December December NNP cord-005453-4057qib7 3891 7 , , , cord-005453-4057qib7 3891 8 2015 2015 CD cord-005453-4057qib7 3891 9 , , , cord-005453-4057qib7 3891 10 564 564 CD cord-005453-4057qib7 3891 11 patients patient NNS cord-005453-4057qib7 3891 12 who who WP cord-005453-4057qib7 3891 13 received receive VBD cord-005453-4057qib7 3891 14 transplantation transplantation NN cord-005453-4057qib7 3891 15 from from IN cord-005453-4057qib7 3891 16 Peking Peking NNP cord-005453-4057qib7 3891 17 University University NNP cord-005453-4057qib7 3891 18 People People NNPS cord-005453-4057qib7 3891 19 's 's POS cord-005453-4057qib7 3891 20 Hospitial Hospitial NNP cord-005453-4057qib7 3891 21 were be VBD cord-005453-4057qib7 3891 22 retrospectively retrospectively RB cord-005453-4057qib7 3891 23 reviewed review VBN cord-005453-4057qib7 3891 24 . . . cord-005453-4057qib7 3892 1 Among among IN cord-005453-4057qib7 3892 2 the the DT cord-005453-4057qib7 3892 3 490 490 CD cord-005453-4057qib7 3892 4 patients patient NNS cord-005453-4057qib7 3892 5 who who WP cord-005453-4057qib7 3892 6 achieved achieve VBD cord-005453-4057qib7 3892 7 initial initial JJ cord-005453-4057qib7 3892 8 engraftment engraftment NN cord-005453-4057qib7 3892 9 , , , cord-005453-4057qib7 3892 10 28 28 CD cord-005453-4057qib7 3892 11 patients patient NNS cord-005453-4057qib7 3892 12 developed develop VBD cord-005453-4057qib7 3892 13 sPGF spgf FW cord-005453-4057qib7 3892 14 . . . cord-005453-4057qib7 3893 1 The the DT cord-005453-4057qib7 3893 2 cumulative cumulative JJ cord-005453-4057qib7 3893 3 incidence incidence NN cord-005453-4057qib7 3893 4 of of IN cord-005453-4057qib7 3893 5 sPGF sPGF NNP cord-005453-4057qib7 3893 6 on on IN cord-005453-4057qib7 3893 7 day day NN cord-005453-4057qib7 3893 8 100 100 CD cord-005453-4057qib7 3893 9 was be VBD cord-005453-4057qib7 3893 10 5.7 5.7 CD cord-005453-4057qib7 3893 11 % % NN cord-005453-4057qib7 3893 12 . . . cord-005453-4057qib7 3894 1 The the DT cord-005453-4057qib7 3894 2 median median JJ cord-005453-4057qib7 3894 3 time time NN cord-005453-4057qib7 3894 4 of of IN cord-005453-4057qib7 3894 5 secondary secondary JJ cord-005453-4057qib7 3894 6 PGF PGF NNP cord-005453-4057qib7 3894 7 was be VBD cord-005453-4057qib7 3895 1 54.5 54.5 CD cord-005453-4057qib7 3895 2 ( ( -LRB- cord-005453-4057qib7 3895 3 34 34 CD cord-005453-4057qib7 3895 4 - - SYM cord-005453-4057qib7 3895 5 91 91 CD cord-005453-4057qib7 3895 6 ) ) -RRB- cord-005453-4057qib7 3895 7 days day NNS cord-005453-4057qib7 3895 8 after after IN cord-005453-4057qib7 3895 9 transplantation transplantation NN cord-005453-4057qib7 3895 10 . . . cord-005453-4057qib7 3896 1 Low low JJ cord-005453-4057qib7 3896 2 ( ( -LRB- cord-005453-4057qib7 3896 3 < < XX cord-005453-4057qib7 3896 4 median median NN cord-005453-4057qib7 3896 5 ) ) -RRB- cord-005453-4057qib7 3897 1 CD34 CD34 NNP cord-005453-4057qib7 3897 2 + + CC cord-005453-4057qib7 3897 3 cell cell NN cord-005453-4057qib7 3897 4 dose dose NN cord-005453-4057qib7 3897 5 ( ( -LRB- cord-005453-4057qib7 3897 6 p=0.019 p=0.019 NNP cord-005453-4057qib7 3897 7 , , , cord-005453-4057qib7 3897 8 HR HR NNP cord-005453-4057qib7 3897 9 3.07(95%CI 3.07(95%ci CD cord-005453-4057qib7 3897 10 , , , cord-005453-4057qib7 3897 11 1.207 1.207 CD cord-005453-4057qib7 3897 12 - - SYM cord-005453-4057qib7 3897 13 7.813 7.813 CD cord-005453-4057qib7 3897 14 ) ) -RRB- cord-005453-4057qib7 3897 15 ) ) -RRB- cord-005453-4057qib7 3897 16 , , , cord-005453-4057qib7 3897 17 EBV EBV NNP cord-005453-4057qib7 3897 18 reactivation reactivation NN cord-005453-4057qib7 3897 19 ( ( -LRB- cord-005453-4057qib7 3897 20 p=0.009 p=0.009 NN cord-005453-4057qib7 3897 21 , , , cord-005453-4057qib7 3897 22 HR HR NNP cord-005453-4057qib7 3897 23 3.648(95%CI 3.648(95%ci CD cord-005453-4057qib7 3897 24 , , , cord-005453-4057qib7 3897 25 1.382 1.382 CD cord-005453-4057qib7 3897 26 - - HYPH cord-005453-4057qib7 3897 27 9.629 9.629 CD cord-005453-4057qib7 3897 28 ) ) -RRB- cord-005453-4057qib7 3897 29 ) ) -RRB- cord-005453-4057qib7 3897 30 and and CC cord-005453-4057qib7 3897 31 CMV CMV NNP cord-005453-4057qib7 3897 32 reactivation reactivation NN cord-005453-4057qib7 3897 33 ( ( -LRB- cord-005453-4057qib7 3897 34 p=0.003 p=0.003 NNP cord-005453-4057qib7 3897 35 , , , cord-005453-4057qib7 3897 36 HR HR NNP cord-005453-4057qib7 3897 37 7.827 7.827 CD cord-005453-4057qib7 3897 38 ( ( -LRB- cord-005453-4057qib7 3898 1 95%CI 95%ci CD cord-005453-4057qib7 3898 2 , , , cord-005453-4057qib7 3898 3 2.002 2.002 CD cord-005453-4057qib7 3898 4 - - HYPH cord-005453-4057qib7 3898 5 30.602 30.602 CD cord-005453-4057qib7 3898 6 ) ) -RRB- cord-005453-4057qib7 3898 7 ) ) -RRB- cord-005453-4057qib7 3898 8 were be VBD cord-005453-4057qib7 3898 9 identified identify VBN cord-005453-4057qib7 3898 10 as as IN cord-005453-4057qib7 3898 11 independent independent JJ cord-005453-4057qib7 3898 12 risk risk NN cord-005453-4057qib7 3898 13 factors factor NNS cord-005453-4057qib7 3898 14 with with IN cord-005453-4057qib7 3898 15 sPGF sPGF NNP cord-005453-4057qib7 3898 16 . . . cord-005453-4057qib7 3899 1 There there EX cord-005453-4057qib7 3899 2 is be VBZ cord-005453-4057qib7 3899 3 no no DT cord-005453-4057qib7 3899 4 significant significant JJ cord-005453-4057qib7 3899 5 difference difference NN cord-005453-4057qib7 3899 6 of of IN cord-005453-4057qib7 3899 7 PGF PGF NNP cord-005453-4057qib7 3899 8 incidence incidence NN cord-005453-4057qib7 3899 9 in in IN cord-005453-4057qib7 3899 10 MSD MSD NNP cord-005453-4057qib7 3899 11 group group NN cord-005453-4057qib7 3899 12 and and CC cord-005453-4057qib7 3899 13 HID HID NNP cord-005453-4057qib7 3899 14 patients patient NNS cord-005453-4057qib7 3899 15 ( ( -LRB- cord-005453-4057qib7 3899 16 p=0.44 p=0.44 NNS cord-005453-4057qib7 3899 17 ) ) -RRB- cord-005453-4057qib7 3899 18 . . . cord-005453-4057qib7 3900 1 The the DT cord-005453-4057qib7 3900 2 overall overall JJ cord-005453-4057qib7 3900 3 survival survival NN cord-005453-4057qib7 3900 4 of of IN cord-005453-4057qib7 3900 5 patients patient NNS cord-005453-4057qib7 3900 6 with with IN cord-005453-4057qib7 3900 7 sPGF sPGF NNP cord-005453-4057qib7 3900 8 at at IN cord-005453-4057qib7 3900 9 1 1 CD cord-005453-4057qib7 3900 10 year year NN cord-005453-4057qib7 3900 11 after after IN cord-005453-4057qib7 3900 12 transplantation transplantation NN cord-005453-4057qib7 3900 13 was be VBD cord-005453-4057qib7 3900 14 significantly significantly RB cord-005453-4057qib7 3900 15 poor poor JJ cord-005453-4057qib7 3900 16 than than IN cord-005453-4057qib7 3900 17 patients patient NNS cord-005453-4057qib7 3900 18 with with IN cord-005453-4057qib7 3900 19 GGF GGF NNP cord-005453-4057qib7 3900 20 ( ( -LRB- cord-005453-4057qib7 3900 21 50.5 50.5 CD cord-005453-4057qib7 3900 22 % % NN cord-005453-4057qib7 3900 23 versus versus IN cord-005453-4057qib7 3900 24 87.2 87.2 CD cord-005453-4057qib7 3900 25 % % NN cord-005453-4057qib7 3900 26 , , , cord-005453-4057qib7 3900 27 p p NN cord-005453-4057qib7 3900 28 < < XX cord-005453-4057qib7 3900 29 0.001 0.001 CD cord-005453-4057qib7 3900 30 ) ) -RRB- cord-005453-4057qib7 3900 31 . . . cord-005453-4057qib7 3901 1 Conclusions conclusion NNS cord-005453-4057qib7 3901 2 : : : cord-005453-4057qib7 3902 1 In in IN cord-005453-4057qib7 3902 2 conclusion conclusion NN cord-005453-4057qib7 3902 3 , , , cord-005453-4057qib7 3902 4 sPGF spgf FW cord-005453-4057qib7 3902 5 develop develop VBP cord-005453-4057qib7 3902 6 in in IN cord-005453-4057qib7 3902 7 5.7 5.7 CD cord-005453-4057qib7 3902 8 % % NN cord-005453-4057qib7 3902 9 patients patient NNS cord-005453-4057qib7 3902 10 after after IN cord-005453-4057qib7 3902 11 allo allo NN cord-005453-4057qib7 3902 12 - - HYPH cord-005453-4057qib7 3902 13 SCT SCT NNP cord-005453-4057qib7 3902 14 , , , cord-005453-4057qib7 3902 15 especially especially RB cord-005453-4057qib7 3902 16 in in IN cord-005453-4057qib7 3902 17 patients patient NNS cord-005453-4057qib7 3902 18 with with IN cord-005453-4057qib7 3902 19 CMV CMV NNP cord-005453-4057qib7 3902 20 , , , cord-005453-4057qib7 3902 21 EBV EBV NNP cord-005453-4057qib7 3902 22 reactivation reactivation NN cord-005453-4057qib7 3902 23 or or CC cord-005453-4057qib7 3902 24 infused infuse VBN cord-005453-4057qib7 3902 25 with with IN cord-005453-4057qib7 3902 26 low low JJ cord-005453-4057qib7 3902 27 dose dose NN cord-005453-4057qib7 3902 28 of of IN cord-005453-4057qib7 3902 29 CD34 CD34 NNP cord-005453-4057qib7 3902 30 + + CC cord-005453-4057qib7 3902 31 cell cell NN cord-005453-4057qib7 3902 32 . . . cord-005453-4057qib7 3903 1 The the DT cord-005453-4057qib7 3903 2 prognosis prognosis NN cord-005453-4057qib7 3903 3 of of IN cord-005453-4057qib7 3903 4 sPGF sPGF NNP cord-005453-4057qib7 3903 5 is be VBZ cord-005453-4057qib7 3903 6 still still RB cord-005453-4057qib7 3903 7 poor poor JJ cord-005453-4057qib7 3903 8 due due IN cord-005453-4057qib7 3903 9 to to IN cord-005453-4057qib7 3903 10 lack lack NN cord-005453-4057qib7 3903 11 of of IN cord-005453-4057qib7 3903 12 standard standard JJ cord-005453-4057qib7 3903 13 treatment treatment NN cord-005453-4057qib7 3903 14 . . . cord-005453-4057qib7 3904 1 Disclosure disclosure NN cord-005453-4057qib7 3904 2 : : : cord-005453-4057qib7 3904 3 There there EX cord-005453-4057qib7 3904 4 is be VBZ cord-005453-4057qib7 3904 5 no no DT cord-005453-4057qib7 3904 6 conflict conflict NN cord-005453-4057qib7 3904 7 of of IN cord-005453-4057qib7 3904 8 interet interet NN cord-005453-4057qib7 3904 9 Thiotepa Thiotepa NNP cord-005453-4057qib7 3904 10 with with IN cord-005453-4057qib7 3904 11 treosulfan treosulfan NNP cord-005453-4057qib7 3904 12 and and CC cord-005453-4057qib7 3904 13 busulfan busulfan NN cord-005453-4057qib7 3904 14 based base VBN cord-005453-4057qib7 3904 15 conditioning conditioning NN cord-005453-4057qib7 3904 16 are be VBP cord-005453-4057qib7 3904 17 significantly significantly RB cord-005453-4057qib7 3904 18 more more RBR cord-005453-4057qib7 3904 19 gonadotoxic gonadotoxic JJ cord-005453-4057qib7 3904 20 than than IN cord-005453-4057qib7 3904 21 treosulfan treosulfan NNP cord-005453-4057qib7 3905 1 Previous previous JJ cord-005453-4057qib7 3905 2 studies study NNS cord-005453-4057qib7 3905 3 suggest suggest VBP cord-005453-4057qib7 3905 4 that that IN cord-005453-4057qib7 3905 5 busulfan busulfan NN cord-005453-4057qib7 3905 6 results result NNS cord-005453-4057qib7 3905 7 in in IN cord-005453-4057qib7 3905 8 long long JJ cord-005453-4057qib7 3905 9 - - HYPH cord-005453-4057qib7 3905 10 term term NN cord-005453-4057qib7 3905 11 gonadal gonadal JJ cord-005453-4057qib7 3905 12 toxicity toxicity NN cord-005453-4057qib7 3905 13 . . . cord-005453-4057qib7 3906 1 No no DT cord-005453-4057qib7 3906 2 previous previous JJ cord-005453-4057qib7 3906 3 studies study NNS cord-005453-4057qib7 3906 4 have have VBP cord-005453-4057qib7 3906 5 compared compare VBN cord-005453-4057qib7 3906 6 gonadal gonadal JJ cord-005453-4057qib7 3906 7 toxicity toxicity NN cord-005453-4057qib7 3906 8 outcomes outcome NNS cord-005453-4057qib7 3906 9 after after IN cord-005453-4057qib7 3906 10 treatment treatment NN cord-005453-4057qib7 3906 11 with with IN cord-005453-4057qib7 3906 12 busulfan busulfan NNP cord-005453-4057qib7 3906 13 with with IN cord-005453-4057qib7 3906 14 treosulfan treosulfan NNP cord-005453-4057qib7 3906 15 , , , cord-005453-4057qib7 3906 16 a a DT cord-005453-4057qib7 3906 17 newer new JJR cord-005453-4057qib7 3906 18 agent agent NN cord-005453-4057qib7 3906 19 with with IN cord-005453-4057qib7 3906 20 similar similar JJ cord-005453-4057qib7 3906 21 marrow marrow NN cord-005453-4057qib7 3906 22 toxicity toxicity NN cord-005453-4057qib7 3906 23 to to IN cord-005453-4057qib7 3906 24 busulfan busulfan NN cord-005453-4057qib7 3906 25 but but CC cord-005453-4057qib7 3906 26 with with IN cord-005453-4057qib7 3906 27 reduced reduce VBN cord-005453-4057qib7 3906 28 non non JJ cord-005453-4057qib7 3906 29 - - JJ cord-005453-4057qib7 3906 30 marrow marrow JJ cord-005453-4057qib7 3906 31 toxcitiy toxcitiy NNS cord-005453-4057qib7 3906 32 . . . cord-005453-4057qib7 3907 1 Our -PRON- PRP$ cord-005453-4057qib7 3907 2 aim aim NN cord-005453-4057qib7 3907 3 was be VBD cord-005453-4057qib7 3907 4 to to TO cord-005453-4057qib7 3907 5 determine determine VB cord-005453-4057qib7 3907 6 whether whether IN cord-005453-4057qib7 3907 7 there there EX cord-005453-4057qib7 3907 8 are be VBP cord-005453-4057qib7 3907 9 differences difference NNS cord-005453-4057qib7 3907 10 in in IN cord-005453-4057qib7 3907 11 pubertal pubertal JJ cord-005453-4057qib7 3907 12 and and CC cord-005453-4057qib7 3907 13 fertility fertility NN cord-005453-4057qib7 3907 14 outcomes outcome NNS cord-005453-4057qib7 3907 15 in in IN cord-005453-4057qib7 3907 16 paediatric paediatric JJ cord-005453-4057qib7 3907 17 patients patient NNS cord-005453-4057qib7 3907 18 treated treat VBN cord-005453-4057qib7 3907 19 with with IN cord-005453-4057qib7 3907 20 treosulfan treosulfan NNP cord-005453-4057qib7 3907 21 compared compare VBN cord-005453-4057qib7 3907 22 with with IN cord-005453-4057qib7 3907 23 busulfan busulfan NN cord-005453-4057qib7 3907 24 . . . cord-005453-4057qib7 3908 1 Methods method NNS cord-005453-4057qib7 3908 2 : : : cord-005453-4057qib7 3909 1 Inclusion inclusion NN cord-005453-4057qib7 3909 2 criteria criterion NNS cord-005453-4057qib7 3909 3 were be VBD cord-005453-4057qib7 3909 4 patients patient NNS cord-005453-4057qib7 3909 5 who who WP cord-005453-4057qib7 3909 6 had have VBD cord-005453-4057qib7 3909 7 received receive VBN cord-005453-4057qib7 3909 8 either either CC cord-005453-4057qib7 3909 9 busulfan busulfan NN cord-005453-4057qib7 3909 10 or or CC cord-005453-4057qib7 3909 11 treosulfan treosulfan NNP cord-005453-4057qib7 3909 12 or or CC cord-005453-4057qib7 3909 13 treosulfan treosulfan NNP cord-005453-4057qib7 3909 14 with with IN cord-005453-4057qib7 3909 15 thiotepa thiotepa NNP cord-005453-4057qib7 3909 16 , , , cord-005453-4057qib7 3909 17 only only RB cord-005453-4057qib7 3909 18 one one CD cord-005453-4057qib7 3909 19 HCT hct NN cord-005453-4057qib7 3909 20 and and CC cord-005453-4057qib7 3909 21 were be VBD cord-005453-4057qib7 3909 22 aged age VBN cord-005453-4057qib7 3909 23 14 14 CD cord-005453-4057qib7 3909 24 years year NNS cord-005453-4057qib7 3909 25 and and CC cord-005453-4057qib7 3909 26 above above RB cord-005453-4057qib7 3909 27 in in IN cord-005453-4057qib7 3909 28 August August NNP cord-005453-4057qib7 3909 29 2018 2018 CD cord-005453-4057qib7 3909 30 . . . cord-005453-4057qib7 3910 1 Eligible eligible JJ cord-005453-4057qib7 3910 2 patients patient NNS cord-005453-4057qib7 3910 3 were be VBD cord-005453-4057qib7 3910 4 reviewed review VBN cord-005453-4057qib7 3910 5 in in IN cord-005453-4057qib7 3910 6 clinic clinic NN cord-005453-4057qib7 3910 7 as as IN cord-005453-4057qib7 3910 8 part part NN cord-005453-4057qib7 3910 9 of of IN cord-005453-4057qib7 3910 10 their -PRON- PRP$ cord-005453-4057qib7 3910 11 routine routine JJ cord-005453-4057qib7 3910 12 follow follow NN cord-005453-4057qib7 3910 13 - - HYPH cord-005453-4057qib7 3910 14 up up NN cord-005453-4057qib7 3910 15 , , , cord-005453-4057qib7 3910 16 thus thus RB cord-005453-4057qib7 3910 17 research research NN cord-005453-4057qib7 3910 18 ethical ethical JJ cord-005453-4057qib7 3910 19 approval approval NN cord-005453-4057qib7 3910 20 was be VBD cord-005453-4057qib7 3910 21 not not RB cord-005453-4057qib7 3910 22 required require VBN cord-005453-4057qib7 3910 23 . . . cord-005453-4057qib7 3911 1 Follice Follice NNP cord-005453-4057qib7 3911 2 Stimulating Stimulating NNP cord-005453-4057qib7 3911 3 Hormone Hormone NNP cord-005453-4057qib7 3911 4 , , , cord-005453-4057qib7 3911 5 Luteinising Luteinising NNP cord-005453-4057qib7 3911 6 Hormone Hormone NNP cord-005453-4057qib7 3911 7 , , , cord-005453-4057qib7 3911 8 oestradiol oestradiol NN cord-005453-4057qib7 3911 9 , , , cord-005453-4057qib7 3911 10 and and CC cord-005453-4057qib7 3911 11 pubertal pubertal JJ cord-005453-4057qib7 3911 12 history history NN cord-005453-4057qib7 3911 13 were be VBD cord-005453-4057qib7 3911 14 noted note VBN cord-005453-4057qib7 3911 15 . . . cord-005453-4057qib7 3912 1 Ovarian Ovarian NNP cord-005453-4057qib7 3912 2 reserve reserve NN cord-005453-4057qib7 3912 3 was be VBD cord-005453-4057qib7 3912 4 estimated estimate VBN cord-005453-4057qib7 3912 5 in in IN cord-005453-4057qib7 3912 6 female female JJ cord-005453-4057qib7 3912 7 patients patient NNS cord-005453-4057qib7 3912 8 by by IN cord-005453-4057qib7 3912 9 measuring measure VBG cord-005453-4057qib7 3912 10 serum serum NN cord-005453-4057qib7 3912 11 Anti anti JJ cord-005453-4057qib7 3912 12 - - JJ cord-005453-4057qib7 3912 13 Mullerian mullerian JJ cord-005453-4057qib7 3912 14 Hormone hormone NN cord-005453-4057qib7 3912 15 ( ( -LRB- cord-005453-4057qib7 3912 16 AMH AMH NNP cord-005453-4057qib7 3912 17 ) ) -RRB- cord-005453-4057qib7 3912 18 . . . cord-005453-4057qib7 3913 1 Male male JJ cord-005453-4057qib7 3913 2 patients patient NNS cord-005453-4057qib7 3913 3 had have VBD cord-005453-4057qib7 3913 4 serum serum NN cord-005453-4057qib7 3913 5 testosterone testosterone NN cord-005453-4057qib7 3913 6 measured measure VBN cord-005453-4057qib7 3913 7 and and CC cord-005453-4057qib7 3913 8 were be VBD cord-005453-4057qib7 3913 9 also also RB cord-005453-4057qib7 3913 10 offered offer VBN cord-005453-4057qib7 3913 11 semen semen NN cord-005453-4057qib7 3913 12 analysis analysis NN cord-005453-4057qib7 3913 13 . . . cord-005453-4057qib7 3914 1 Results result NNS cord-005453-4057qib7 3914 2 : : : cord-005453-4057qib7 3915 1 Thirty thirty CD cord-005453-4057qib7 3915 2 - - HYPH cord-005453-4057qib7 3915 3 five five CD cord-005453-4057qib7 3915 4 patients patient NNS cord-005453-4057qib7 3915 5 met meet VBD cord-005453-4057qib7 3915 6 the the DT cord-005453-4057qib7 3915 7 inclusion inclusion NN cord-005453-4057qib7 3915 8 criteria criterion NNS cord-005453-4057qib7 3915 9 , , , cord-005453-4057qib7 3915 10 of of IN cord-005453-4057qib7 3915 11 which which WDT cord-005453-4057qib7 3915 12 twenty twenty CD cord-005453-4057qib7 3915 13 - - HYPH cord-005453-4057qib7 3915 14 five five CD cord-005453-4057qib7 3915 15 wanted want VBD cord-005453-4057qib7 3915 16 to to TO cord-005453-4057qib7 3915 17 be be VB cord-005453-4057qib7 3915 18 reviewed review VBN cord-005453-4057qib7 3915 19 ( ( -LRB- cord-005453-4057qib7 3915 20 71 71 CD cord-005453-4057qib7 3915 21 % % NN cord-005453-4057qib7 3915 22 ) ) -RRB- cord-005453-4057qib7 3915 23 ; ; : cord-005453-4057qib7 3915 24 seventeen seventeen CD cord-005453-4057qib7 3915 25 females female NNS cord-005453-4057qib7 3915 26 and and CC cord-005453-4057qib7 3915 27 eight eight CD cord-005453-4057qib7 3915 28 males male NNS cord-005453-4057qib7 3915 29 . . . cord-005453-4057qib7 3916 1 Mean mean JJ cord-005453-4057qib7 3916 2 age age NN cord-005453-4057qib7 3916 3 at at IN cord-005453-4057qib7 3916 4 HCT HCT NNP cord-005453-4057qib7 3916 5 was be VBD cord-005453-4057qib7 3916 6 13 13 CD cord-005453-4057qib7 3916 7 years year NNS cord-005453-4057qib7 3916 8 , , , cord-005453-4057qib7 3916 9 mean mean VB cord-005453-4057qib7 3916 10 age age NN cord-005453-4057qib7 3916 11 at at IN cord-005453-4057qib7 3916 12 review review NN cord-005453-4057qib7 3916 13 was be VBD cord-005453-4057qib7 3916 14 19 19 CD cord-005453-4057qib7 3916 15 years year NNS cord-005453-4057qib7 3916 16 and and CC cord-005453-4057qib7 3916 17 mean mean VB cord-005453-4057qib7 3916 18 years year NNS cord-005453-4057qib7 3916 19 since since IN cord-005453-4057qib7 3916 20 HCT HCT NNP cord-005453-4057qib7 3916 21 was be VBD cord-005453-4057qib7 3916 22 5 5 CD cord-005453-4057qib7 3916 23 years year NNS cord-005453-4057qib7 3916 24 . . . cord-005453-4057qib7 3917 1 Female female JJ cord-005453-4057qib7 3917 2 patients patient NNS cord-005453-4057qib7 3917 3 treated treat VBN cord-005453-4057qib7 3917 4 with with IN cord-005453-4057qib7 3917 5 busulfan busulfan NN cord-005453-4057qib7 3917 6 or or CC cord-005453-4057qib7 3917 7 treosulfan treosulfan NNP cord-005453-4057qib7 3917 8 with with IN cord-005453-4057qib7 3917 9 thiotepa thiotepa NNP cord-005453-4057qib7 3917 10 ( ( -LRB- cord-005453-4057qib7 3917 11 n=14 n=14 NNP cord-005453-4057qib7 3917 12 ) ) -RRB- cord-005453-4057qib7 3917 13 had have VBD cord-005453-4057qib7 3917 14 minimal minimal JJ cord-005453-4057qib7 3917 15 AMH amh NN cord-005453-4057qib7 3917 16 and and CC cord-005453-4057qib7 3917 17 none none NN cord-005453-4057qib7 3917 18 of of IN cord-005453-4057qib7 3917 19 these these DT cord-005453-4057qib7 3917 20 patients patient NNS cord-005453-4057qib7 3917 21 were be VBD cord-005453-4057qib7 3917 22 having have VBG cord-005453-4057qib7 3917 23 regular regular JJ cord-005453-4057qib7 3917 24 periods period NNS cord-005453-4057qib7 3917 25 . . . cord-005453-4057qib7 3918 1 Females female NNS cord-005453-4057qib7 3918 2 treated treat VBN cord-005453-4057qib7 3918 3 with with IN cord-005453-4057qib7 3918 4 treosulfan treosulfan NNP cord-005453-4057qib7 3918 5 ( ( -LRB- cord-005453-4057qib7 3918 6 n=3 n=3 NN cord-005453-4057qib7 3918 7 ) ) -RRB- cord-005453-4057qib7 3918 8 had have VBD cord-005453-4057qib7 3918 9 normal normal JJ cord-005453-4057qib7 3918 10 AMH amh NN cord-005453-4057qib7 3918 11 and and CC cord-005453-4057qib7 3918 12 regular regular JJ cord-005453-4057qib7 3918 13 periods period NNS cord-005453-4057qib7 3918 14 without without IN cord-005453-4057qib7 3918 15 needing need VBG cord-005453-4057qib7 3918 16 hormone hormone NN cord-005453-4057qib7 3918 17 replacement replacement NN cord-005453-4057qib7 3918 18 . . . cord-005453-4057qib7 3919 1 Only only RB cord-005453-4057qib7 3919 2 four four CD cord-005453-4057qib7 3919 3 male male JJ cord-005453-4057qib7 3919 4 patients patient NNS cord-005453-4057qib7 3919 5 opted opt VBD cord-005453-4057qib7 3919 6 for for IN cord-005453-4057qib7 3919 7 a a DT cord-005453-4057qib7 3919 8 semen semen NN cord-005453-4057qib7 3919 9 analysis analysis NN cord-005453-4057qib7 3919 10 and and CC cord-005453-4057qib7 3919 11 all all DT cord-005453-4057qib7 3919 12 had have VBD cord-005453-4057qib7 3919 13 significantly significantly RB cord-005453-4057qib7 3919 14 reduced reduce VBN cord-005453-4057qib7 3919 15 sperm sperm NN cord-005453-4057qib7 3919 16 counts count NNS cord-005453-4057qib7 3919 17 . . . cord-005453-4057qib7 3920 1 Conclusions conclusion NNS cord-005453-4057qib7 3920 2 : : : cord-005453-4057qib7 3921 1 Our -PRON- PRP$ cord-005453-4057qib7 3921 2 results result NNS cord-005453-4057qib7 3921 3 suggest suggest VBP cord-005453-4057qib7 3921 4 that that IN cord-005453-4057qib7 3921 5 females female NNS cord-005453-4057qib7 3921 6 treated treat VBN cord-005453-4057qib7 3921 7 with with IN cord-005453-4057qib7 3921 8 treosulfan treosulfan NNP cord-005453-4057qib7 3921 9 have have VBP cord-005453-4057qib7 3921 10 minimal minimal JJ cord-005453-4057qib7 3921 11 ( ( -LRB- cord-005453-4057qib7 3921 12 if if IN cord-005453-4057qib7 3921 13 any any DT cord-005453-4057qib7 3921 14 ) ) -RRB- cord-005453-4057qib7 3921 15 reduction reduction NN cord-005453-4057qib7 3921 16 in in IN cord-005453-4057qib7 3921 17 ovarian ovarian JJ cord-005453-4057qib7 3921 18 reserve reserve NN cord-005453-4057qib7 3921 19 compared compare VBN cord-005453-4057qib7 3921 20 to to IN cord-005453-4057qib7 3921 21 other other JJ cord-005453-4057qib7 3921 22 conditioning conditioning NN cord-005453-4057qib7 3921 23 regimens regimen NNS cord-005453-4057qib7 3921 24 which which WDT cord-005453-4057qib7 3921 25 casue casue VBP cord-005453-4057qib7 3921 26 significant significant JJ cord-005453-4057qib7 3921 27 compromise compromise NN cord-005453-4057qib7 3921 28 . . . cord-005453-4057qib7 3922 1 Although although IN cord-005453-4057qib7 3922 2 this this DT cord-005453-4057qib7 3922 3 was be VBD cord-005453-4057qib7 3922 4 a a DT cord-005453-4057qib7 3922 5 small small JJ cord-005453-4057qib7 3922 6 study study NN cord-005453-4057qib7 3922 7 , , , cord-005453-4057qib7 3922 8 and and CC cord-005453-4057qib7 3922 9 thus thus RB cord-005453-4057qib7 3922 10 not not RB cord-005453-4057qib7 3922 11 suitable suitable JJ cord-005453-4057qib7 3922 12 for for IN cord-005453-4057qib7 3922 13 statistical statistical JJ cord-005453-4057qib7 3922 14 analysis analysis NN cord-005453-4057qib7 3922 15 , , , cord-005453-4057qib7 3922 16 the the DT cord-005453-4057qib7 3922 17 clinical clinical JJ cord-005453-4057qib7 3922 18 findings finding NNS cord-005453-4057qib7 3922 19 are be VBP cord-005453-4057qib7 3922 20 marked mark VBN cord-005453-4057qib7 3922 21 . . . cord-005453-4057qib7 3923 1 Future future JJ cord-005453-4057qib7 3923 2 studies study NNS cord-005453-4057qib7 3923 3 should should MD cord-005453-4057qib7 3923 4 further further RB cord-005453-4057qib7 3923 5 investigate investigate VB cord-005453-4057qib7 3923 6 optimal optimal JJ cord-005453-4057qib7 3923 7 doses dose NNS cord-005453-4057qib7 3923 8 of of IN cord-005453-4057qib7 3923 9 treosulfan treosulfan NNP cord-005453-4057qib7 3923 10 that that WDT cord-005453-4057qib7 3923 11 could could MD cord-005453-4057qib7 3923 12 be be VB cord-005453-4057qib7 3923 13 used use VBN cord-005453-4057qib7 3923 14 to to TO cord-005453-4057qib7 3923 15 achieve achieve VB cord-005453-4057qib7 3923 16 bone bone NN cord-005453-4057qib7 3923 17 marrow marrow NN cord-005453-4057qib7 3923 18 engraftment engraftment NN cord-005453-4057qib7 3923 19 and and CC cord-005453-4057qib7 3923 20 limit limit VB cord-005453-4057qib7 3923 21 long long JJ cord-005453-4057qib7 3923 22 - - HYPH cord-005453-4057qib7 3923 23 term term NN cord-005453-4057qib7 3923 24 effects effect NNS cord-005453-4057qib7 3923 25 on on IN cord-005453-4057qib7 3923 26 fertility fertility NN cord-005453-4057qib7 3923 27 . . . cord-005453-4057qib7 3924 1 Disclosure disclosure NN cord-005453-4057qib7 3924 2 Background background NN cord-005453-4057qib7 3924 3 : : : cord-005453-4057qib7 3925 1 Autologous autologous JJ cord-005453-4057qib7 3925 2 and and CC cord-005453-4057qib7 3925 3 allogenic allogenic JJ cord-005453-4057qib7 3925 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 3925 5 stem stem NN cord-005453-4057qib7 3925 6 cell cell NN cord-005453-4057qib7 3925 7 transplantation transplantation NN cord-005453-4057qib7 3925 8 ( ( -LRB- cord-005453-4057qib7 3925 9 HSCT HSCT NNP cord-005453-4057qib7 3925 10 ) ) -RRB- cord-005453-4057qib7 3925 11 are be VBP cord-005453-4057qib7 3925 12 potentially potentially RB cord-005453-4057qib7 3925 13 curative curative JJ cord-005453-4057qib7 3925 14 treatments treatment NNS cord-005453-4057qib7 3925 15 for for IN cord-005453-4057qib7 3925 16 hematological hematological JJ cord-005453-4057qib7 3925 17 malignancies malignancy NNS cord-005453-4057qib7 3925 18 . . . cord-005453-4057qib7 3926 1 Patients patient NNS cord-005453-4057qib7 3926 2 with with IN cord-005453-4057qib7 3926 3 related related JJ cord-005453-4057qib7 3926 4 complications complication NNS cord-005453-4057qib7 3926 5 may may MD cord-005453-4057qib7 3926 6 need need VB cord-005453-4057qib7 3926 7 admission admission NN cord-005453-4057qib7 3926 8 to to IN cord-005453-4057qib7 3926 9 the the DT cord-005453-4057qib7 3926 10 intensive intensive JJ cord-005453-4057qib7 3926 11 care care NN cord-005453-4057qib7 3926 12 unit unit NN cord-005453-4057qib7 3926 13 ( ( -LRB- cord-005453-4057qib7 3926 14 ICU ICU NNP cord-005453-4057qib7 3926 15 ) ) -RRB- cord-005453-4057qib7 3926 16 for for IN cord-005453-4057qib7 3926 17 specific specific JJ cord-005453-4057qib7 3926 18 therapy therapy NN cord-005453-4057qib7 3926 19 and and CC cord-005453-4057qib7 3926 20 organ organ NN cord-005453-4057qib7 3926 21 support support NN cord-005453-4057qib7 3926 22 . . . cord-005453-4057qib7 3927 1 Mortality mortality NN cord-005453-4057qib7 3927 2 risk risk NN cord-005453-4057qib7 3927 3 factors factor NNS cord-005453-4057qib7 3927 4 , , , cord-005453-4057qib7 3927 5 supportive supportive JJ cord-005453-4057qib7 3927 6 care care NN cord-005453-4057qib7 3927 7 and and CC cord-005453-4057qib7 3927 8 principal principal JJ cord-005453-4057qib7 3927 9 causes cause NNS cord-005453-4057qib7 3927 10 of of IN cord-005453-4057qib7 3927 11 admission admission NN cord-005453-4057qib7 3927 12 in in IN cord-005453-4057qib7 3927 13 ICU ICU NNP cord-005453-4057qib7 3927 14 are be VBP cord-005453-4057qib7 3927 15 described describe VBN cord-005453-4057qib7 3927 16 in in IN cord-005453-4057qib7 3927 17 our -PRON- PRP$ cord-005453-4057qib7 3927 18 cohort cohort NN cord-005453-4057qib7 3927 19 of of IN cord-005453-4057qib7 3927 20 patients patient NNS cord-005453-4057qib7 3927 21 ( ( -LRB- cord-005453-4057qib7 3927 22 pts pts NNP cord-005453-4057qib7 3927 23 ) ) -RRB- cord-005453-4057qib7 3927 24 . . . cord-005453-4057qib7 3928 1 Methods method NNS cord-005453-4057qib7 3928 2 : : : cord-005453-4057qib7 3929 1 We -PRON- PRP cord-005453-4057qib7 3929 2 retrospectively retrospectively RB cord-005453-4057qib7 3929 3 studied study VBD cord-005453-4057qib7 3929 4 326 326 CD cord-005453-4057qib7 3929 5 pts pt NNS cord-005453-4057qib7 3929 6 , , , cord-005453-4057qib7 3929 7 185 185 CD cord-005453-4057qib7 3929 8 male male NN cord-005453-4057qib7 3929 9 , , , cord-005453-4057qib7 3929 10 with with IN cord-005453-4057qib7 3929 11 a a DT cord-005453-4057qib7 3929 12 median median JJ cord-005453-4057qib7 3929 13 age age NN cord-005453-4057qib7 3929 14 of of IN cord-005453-4057qib7 3929 15 56,63 56,63 CD cord-005453-4057qib7 3929 16 years year NNS cord-005453-4057qib7 3929 17 ( ( -LRB- cord-005453-4057qib7 3929 18 range range NN cord-005453-4057qib7 3929 19 : : : cord-005453-4057qib7 3929 20 18 18 CD cord-005453-4057qib7 3929 21 - - SYM cord-005453-4057qib7 3929 22 73 73 CD cord-005453-4057qib7 3929 23 ) ) -RRB- cord-005453-4057qib7 3929 24 who who WP cord-005453-4057qib7 3929 25 underwent undergo VBD cord-005453-4057qib7 3929 26 allo allo NN cord-005453-4057qib7 3929 27 - - HYPH cord-005453-4057qib7 3929 28 HSCT HSCT NNP cord-005453-4057qib7 3929 29 in in IN cord-005453-4057qib7 3929 30 our -PRON- PRP$ cord-005453-4057qib7 3929 31 center center NN cord-005453-4057qib7 3929 32 between between IN cord-005453-4057qib7 3929 33 July July NNP cord-005453-4057qib7 3929 34 2014 2014 CD cord-005453-4057qib7 3929 35 and and CC cord-005453-4057qib7 3929 36 October October NNP cord-005453-4057qib7 3929 37 2018 2018 CD cord-005453-4057qib7 3929 38 . . . cord-005453-4057qib7 3930 1 Two two CD cord-005453-4057qib7 3930 2 hundred hundred CD cord-005453-4057qib7 3930 3 and and CC cord-005453-4057qib7 3930 4 twenty twenty CD cord-005453-4057qib7 3930 5 - - HYPH cord-005453-4057qib7 3930 6 seven(69,6 seven(69,6 NN cord-005453-4057qib7 3930 7 % % NN cord-005453-4057qib7 3930 8 ) ) -RRB- cord-005453-4057qib7 3930 9 pts pt NNS cord-005453-4057qib7 3930 10 received receive VBD cord-005453-4057qib7 3930 11 autologous autologous JJ cord-005453-4057qib7 3930 12 HSCT HSCT NNP cord-005453-4057qib7 3930 13 ( ( -LRB- cord-005453-4057qib7 3930 14 auto auto NN cord-005453-4057qib7 3930 15 - - HYPH cord-005453-4057qib7 3930 16 HCT hct NN cord-005453-4057qib7 3930 17 ) ) -RRB- cord-005453-4057qib7 3931 1 and and CC cord-005453-4057qib7 3931 2 99 99 CD cord-005453-4057qib7 3931 3 ( ( -LRB- cord-005453-4057qib7 3931 4 30,4 30,4 CD cord-005453-4057qib7 3931 5 % % NN cord-005453-4057qib7 3931 6 ) ) -RRB- cord-005453-4057qib7 3931 7 allogenic allogenic JJ cord-005453-4057qib7 3931 8 HSCT HSCT NNP cord-005453-4057qib7 3931 9 ( ( -LRB- cord-005453-4057qib7 3931 10 allo allo NN cord-005453-4057qib7 3931 11 - - HYPH cord-005453-4057qib7 3931 12 HSCT HSCT NNP cord-005453-4057qib7 3931 13 ) ) -RRB- cord-005453-4057qib7 3931 14 ; ; : cord-005453-4057qib7 3931 15 50 50 CD cord-005453-4057qib7 3931 16 from from IN cord-005453-4057qib7 3931 17 unrelated unrelated JJ cord-005453-4057qib7 3931 18 donor donor NN cord-005453-4057qib7 3931 19 , , , cord-005453-4057qib7 3931 20 38 38 CD cord-005453-4057qib7 3931 21 from from IN cord-005453-4057qib7 3931 22 identical identical JJ cord-005453-4057qib7 3931 23 sibling sibling NN cord-005453-4057qib7 3931 24 , , , cord-005453-4057qib7 3931 25 and and CC cord-005453-4057qib7 3931 26 the the DT cord-005453-4057qib7 3931 27 remainder remainder NN cord-005453-4057qib7 3931 28 , , , cord-005453-4057qib7 3931 29 mismatched mismatch VBN cord-005453-4057qib7 3931 30 related related JJ cord-005453-4057qib7 3931 31 donor donor NN cord-005453-4057qib7 3931 32 11 11 CD cord-005453-4057qib7 3931 33 . . . cord-005453-4057qib7 3932 1 Twenty twenty CD cord-005453-4057qib7 3932 2 - - HYPH cord-005453-4057qib7 3932 3 three three CD cord-005453-4057qib7 3932 4 ( ( -LRB- cord-005453-4057qib7 3932 5 7,1 7,1 CD cord-005453-4057qib7 3932 6 % % NN cord-005453-4057qib7 3932 7 ) ) -RRB- cord-005453-4057qib7 3933 1 out out IN cord-005453-4057qib7 3933 2 of of IN cord-005453-4057qib7 3933 3 326 326 CD cord-005453-4057qib7 3933 4 pts pt NNS cord-005453-4057qib7 3933 5 were be VBD cord-005453-4057qib7 3933 6 admitted admit VBN cord-005453-4057qib7 3933 7 in in IN cord-005453-4057qib7 3933 8 the the DT cord-005453-4057qib7 3933 9 ICU ICU NNP cord-005453-4057qib7 3933 10 in in IN cord-005453-4057qib7 3933 11 the the DT cord-005453-4057qib7 3933 12 transplant transplant NN cord-005453-4057qib7 3933 13 procedure procedure NN cord-005453-4057qib7 3933 14 admission admission NN cord-005453-4057qib7 3933 15 . . . cord-005453-4057qib7 3934 1 Results result NNS cord-005453-4057qib7 3934 2 : : : cord-005453-4057qib7 3935 1 Fifteen fifteen CD cord-005453-4057qib7 3935 2 ( ( -LRB- cord-005453-4057qib7 3935 3 65,2 65,2 CD cord-005453-4057qib7 3935 4 % % NN cord-005453-4057qib7 3935 5 ) ) -RRB- cord-005453-4057qib7 3936 1 out out IN cord-005453-4057qib7 3936 2 of of IN cord-005453-4057qib7 3936 3 23 23 CD cord-005453-4057qib7 3936 4 pts pt NNS cord-005453-4057qib7 3936 5 were be VBD cord-005453-4057qib7 3936 6 male male JJ cord-005453-4057qib7 3936 7 with with IN cord-005453-4057qib7 3936 8 a a DT cord-005453-4057qib7 3936 9 median median JJ cord-005453-4057qib7 3936 10 age age NN cord-005453-4057qib7 3936 11 of of IN cord-005453-4057qib7 3936 12 55 55 CD cord-005453-4057qib7 3936 13 years year NNS cord-005453-4057qib7 3937 1 ( ( -LRB- cord-005453-4057qib7 3937 2 range range NN cord-005453-4057qib7 3937 3 : : : cord-005453-4057qib7 3937 4 28 28 CD cord-005453-4057qib7 3937 5 - - SYM cord-005453-4057qib7 3937 6 69 69 CD cord-005453-4057qib7 3937 7 ) ) -RRB- cord-005453-4057qib7 3937 8 . . . cord-005453-4057qib7 3938 1 Patients patient NNS cord-005453-4057qib7 3938 2 ' ' POS cord-005453-4057qib7 3938 3 baseline baseline JJ cord-005453-4057qib7 3938 4 diseases disease NNS cord-005453-4057qib7 3938 5 were be VBD cord-005453-4057qib7 3938 6 : : : cord-005453-4057qib7 3938 7 multiple multiple JJ cord-005453-4057qib7 3938 8 myeloma myeloma NN cord-005453-4057qib7 3938 9 ( ( -LRB- cord-005453-4057qib7 3938 10 34,8 34,8 CD cord-005453-4057qib7 3938 11 % % NN cord-005453-4057qib7 3938 12 ) ) -RRB- cord-005453-4057qib7 3938 13 , , , cord-005453-4057qib7 3938 14 non non JJ cord-005453-4057qib7 3938 15 - - JJ cord-005453-4057qib7 3938 16 Hodgkin´s hodgkin´s JJ cord-005453-4057qib7 3938 17 Lymphoma lymphoma NN cord-005453-4057qib7 3938 18 ( ( -LRB- cord-005453-4057qib7 3938 19 26,1 26,1 CD cord-005453-4057qib7 3938 20 % % NN cord-005453-4057qib7 3938 21 ) ) -RRB- cord-005453-4057qib7 3938 22 , , , cord-005453-4057qib7 3938 23 Hodgkin´s Hodgkin´s NNP cord-005453-4057qib7 3938 24 Lymphoma Lymphoma NNP cord-005453-4057qib7 3938 25 ( ( -LRB- cord-005453-4057qib7 3938 26 8,7 8,7 CD cord-005453-4057qib7 3938 27 % % NN cord-005453-4057qib7 3938 28 ) ) -RRB- cord-005453-4057qib7 3938 29 , , , cord-005453-4057qib7 3938 30 acute acute JJ cord-005453-4057qib7 3938 31 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 3938 32 leukemia leukemia NN cord-005453-4057qib7 3938 33 ( ( -LRB- cord-005453-4057qib7 3938 34 8,7 8,7 CD cord-005453-4057qib7 3938 35 % % NN cord-005453-4057qib7 3938 36 ) ) -RRB- cord-005453-4057qib7 3938 37 , , , cord-005453-4057qib7 3938 38 myelodisplasic myelodisplasic NNP cord-005453-4057qib7 3938 39 syndrome syndrome NN cord-005453-4057qib7 3938 40 ( ( -LRB- cord-005453-4057qib7 3938 41 8,7 8,7 CD cord-005453-4057qib7 3938 42 % % NN cord-005453-4057qib7 3938 43 ) ) -RRB- cord-005453-4057qib7 3938 44 , , , cord-005453-4057qib7 3938 45 solid solid JJ cord-005453-4057qib7 3938 46 tumor tumor NN cord-005453-4057qib7 3938 47 ( ( -LRB- cord-005453-4057qib7 3938 48 8,7 8,7 CD cord-005453-4057qib7 3938 49 ) ) -RRB- cord-005453-4057qib7 3938 50 and and CC cord-005453-4057qib7 3938 51 acute acute JJ cord-005453-4057qib7 3938 52 myeloblastic myeloblastic JJ cord-005453-4057qib7 3938 53 leukemia leukemia NN cord-005453-4057qib7 3938 54 ( ( -LRB- cord-005453-4057qib7 3938 55 4,3 4,3 CD cord-005453-4057qib7 3938 56 % % NN cord-005453-4057qib7 3938 57 ) ) -RRB- cord-005453-4057qib7 3938 58 . . . cord-005453-4057qib7 3939 1 Fifteen fifteen CD cord-005453-4057qib7 3939 2 ( ( -LRB- cord-005453-4057qib7 3939 3 65,2 65,2 CD cord-005453-4057qib7 3939 4 % % NN cord-005453-4057qib7 3939 5 ) ) -RRB- cord-005453-4057qib7 3939 6 pts pt NNS cord-005453-4057qib7 3939 7 received receive VBD cord-005453-4057qib7 3939 8 auto auto NN cord-005453-4057qib7 3939 9 - - HYPH cord-005453-4057qib7 3939 10 HSCT HSCT NNP cord-005453-4057qib7 3939 11 , , , cord-005453-4057qib7 3939 12 5 5 CD cord-005453-4057qib7 3939 13 ( ( -LRB- cord-005453-4057qib7 3939 14 21,7 21,7 CD cord-005453-4057qib7 3939 15 % % NN cord-005453-4057qib7 3939 16 ) ) -RRB- cord-005453-4057qib7 3939 17 allo allo NN cord-005453-4057qib7 3939 18 - - HYPH cord-005453-4057qib7 3939 19 HSCT HSCT NNP cord-005453-4057qib7 3939 20 from from IN cord-005453-4057qib7 3939 21 unrelated unrelated JJ cord-005453-4057qib7 3939 22 donor donor NN cord-005453-4057qib7 3939 23 , , , cord-005453-4057qib7 3939 24 2 2 CD cord-005453-4057qib7 3939 25 ( ( -LRB- cord-005453-4057qib7 3939 26 8,7 8,7 CD cord-005453-4057qib7 3939 27 % % NN cord-005453-4057qib7 3939 28 ) ) -RRB- cord-005453-4057qib7 3940 1 allo allo NN cord-005453-4057qib7 3940 2 - - HYPH cord-005453-4057qib7 3940 3 HSCT HSCT NNP cord-005453-4057qib7 3940 4 from from IN cord-005453-4057qib7 3940 5 identical identical JJ cord-005453-4057qib7 3940 6 sibling sibling NN cord-005453-4057qib7 3940 7 , , , cord-005453-4057qib7 3940 8 and and CC cord-005453-4057qib7 3940 9 the the DT cord-005453-4057qib7 3940 10 remainder remainder NN cord-005453-4057qib7 3940 11 haploidentical haploidentical JJ cord-005453-4057qib7 3940 12 HSCT HSCT NNP cord-005453-4057qib7 3940 13 ( ( -LRB- cord-005453-4057qib7 3940 14 1 1 CD cord-005453-4057qib7 3940 15 ) ) -RRB- cord-005453-4057qib7 3940 16 ( ( -LRB- cord-005453-4057qib7 3940 17 4,3 4,3 CD cord-005453-4057qib7 3940 18 % % NN cord-005453-4057qib7 3940 19 ) ) -RRB- cord-005453-4057qib7 3940 20 . . . cord-005453-4057qib7 3941 1 So so RB cord-005453-4057qib7 3941 2 , , , cord-005453-4057qib7 3941 3 6,6 6,6 CD cord-005453-4057qib7 3941 4 % % NN cord-005453-4057qib7 3941 5 of of IN cord-005453-4057qib7 3941 6 auto auto NN cord-005453-4057qib7 3941 7 - - HYPH cord-005453-4057qib7 3941 8 HSCT HSCT NNP cord-005453-4057qib7 3941 9 pts pts NN cord-005453-4057qib7 3941 10 and and CC cord-005453-4057qib7 3941 11 8 8 CD cord-005453-4057qib7 3941 12 % % NN cord-005453-4057qib7 3941 13 of of IN cord-005453-4057qib7 3941 14 allo allo NN cord-005453-4057qib7 3941 15 - - HYPH cord-005453-4057qib7 3941 16 HSCT HSCT NNP cord-005453-4057qib7 3941 17 were be VBD cord-005453-4057qib7 3941 18 admitted admit VBN cord-005453-4057qib7 3941 19 in in IN cord-005453-4057qib7 3941 20 the the DT cord-005453-4057qib7 3941 21 ICU ICU NNP cord-005453-4057qib7 3941 22 . . . cord-005453-4057qib7 3942 1 The the DT cord-005453-4057qib7 3942 2 median median NN cord-005453-4057qib7 3942 3 stay stay NN cord-005453-4057qib7 3942 4 in in IN cord-005453-4057qib7 3942 5 the the DT cord-005453-4057qib7 3942 6 ICU ICU NNP cord-005453-4057qib7 3942 7 was be VBD cord-005453-4057qib7 3942 8 5 5 CD cord-005453-4057qib7 3942 9 days day NNS cord-005453-4057qib7 3942 10 ( ( -LRB- cord-005453-4057qib7 3942 11 range range NN cord-005453-4057qib7 3942 12 : : : cord-005453-4057qib7 3942 13 1 1 CD cord-005453-4057qib7 3942 14 - - SYM cord-005453-4057qib7 3942 15 30 30 CD cord-005453-4057qib7 3942 16 ) ) -RRB- cord-005453-4057qib7 3942 17 and and CC cord-005453-4057qib7 3942 18 reasons reason NNS cord-005453-4057qib7 3942 19 for for IN cord-005453-4057qib7 3942 20 admission admission NN cord-005453-4057qib7 3942 21 were be VBD cord-005453-4057qib7 3942 22 : : : cord-005453-4057qib7 3942 23 respiratory respiratory JJ cord-005453-4057qib7 3942 24 insufficiency insufficiency NN cord-005453-4057qib7 3942 25 ( ( -LRB- cord-005453-4057qib7 3942 26 60,8 60,8 CD cord-005453-4057qib7 3942 27 % % NN cord-005453-4057qib7 3942 28 ) ) -RRB- cord-005453-4057qib7 3942 29 , , , cord-005453-4057qib7 3942 30 septic septic JJ cord-005453-4057qib7 3942 31 shock shock NN cord-005453-4057qib7 3942 32 ( ( -LRB- cord-005453-4057qib7 3942 33 30,4 30,4 CD cord-005453-4057qib7 3942 34 % % NN cord-005453-4057qib7 3942 35 ) ) -RRB- cord-005453-4057qib7 3942 36 , , , cord-005453-4057qib7 3942 37 renal renal JJ cord-005453-4057qib7 3942 38 insufficiency insufficiency NN cord-005453-4057qib7 3942 39 ( ( -LRB- cord-005453-4057qib7 3942 40 4,3 4,3 CD cord-005453-4057qib7 3942 41 % % NN cord-005453-4057qib7 3942 42 ) ) -RRB- cord-005453-4057qib7 3942 43 and and CC cord-005453-4057qib7 3942 44 multi multi JJ cord-005453-4057qib7 3942 45 - - JJ cord-005453-4057qib7 3942 46 organic organic JJ cord-005453-4057qib7 3942 47 failure failure NN cord-005453-4057qib7 3942 48 ( ( -LRB- cord-005453-4057qib7 3942 49 4,3 4,3 CD cord-005453-4057qib7 3942 50 % % NN cord-005453-4057qib7 3942 51 ) ) -RRB- cord-005453-4057qib7 3942 52 . . . cord-005453-4057qib7 3943 1 Twenty twenty CD cord-005453-4057qib7 3943 2 - - HYPH cord-005453-4057qib7 3943 3 one one CD cord-005453-4057qib7 3943 4 ( ( -LRB- cord-005453-4057qib7 3943 5 91.3 91.3 CD cord-005453-4057qib7 3943 6 % % NN cord-005453-4057qib7 3943 7 ) ) -RRB- cord-005453-4057qib7 3943 8 pts pt NNS cord-005453-4057qib7 3943 9 required require VBN cord-005453-4057qib7 3943 10 respiratory respiratory JJ cord-005453-4057qib7 3943 11 support support NN cord-005453-4057qib7 3943 12 with with IN cord-005453-4057qib7 3943 13 : : : cord-005453-4057qib7 3943 14 nasal nasal NN cord-005453-4057qib7 3943 15 cannula cannula NN cord-005453-4057qib7 3943 16 or or CC cord-005453-4057qib7 3943 17 oxygen oxygen NN cord-005453-4057qib7 3943 18 mask mask NN cord-005453-4057qib7 3943 19 ( ( -LRB- cord-005453-4057qib7 3943 20 C C NNP cord-005453-4057qib7 3943 21 / / SYM cord-005453-4057qib7 3943 22 M M NNP cord-005453-4057qib7 3943 23 ) ) -RRB- cord-005453-4057qib7 3943 24 ( ( -LRB- cord-005453-4057qib7 3943 25 19 19 CD cord-005453-4057qib7 3943 26 % % NN cord-005453-4057qib7 3943 27 ) ) -RRB- cord-005453-4057qib7 3943 28 , , , cord-005453-4057qib7 3943 29 non non JJ cord-005453-4057qib7 3943 30 - - JJ cord-005453-4057qib7 3943 31 invasive invasive JJ cord-005453-4057qib7 3943 32 mechanical mechanical JJ cord-005453-4057qib7 3943 33 ventilation ventilation NN cord-005453-4057qib7 3944 1 ( ( -LRB- cord-005453-4057qib7 3944 2 NIMV NIMV NNP cord-005453-4057qib7 3944 3 ) ) -RRB- cord-005453-4057qib7 3945 1 ( ( -LRB- cord-005453-4057qib7 3945 2 66,7 66,7 CD cord-005453-4057qib7 3945 3 % % NN cord-005453-4057qib7 3945 4 ) ) -RRB- cord-005453-4057qib7 3945 5 and and CC cord-005453-4057qib7 3945 6 invasive invasive JJ cord-005453-4057qib7 3945 7 mechanical mechanical JJ cord-005453-4057qib7 3945 8 ventilation ventilation NN cord-005453-4057qib7 3945 9 ( ( -LRB- cord-005453-4057qib7 3945 10 IMV IMV NNP cord-005453-4057qib7 3945 11 ) ) -RRB- cord-005453-4057qib7 3946 1 ( ( -LRB- cord-005453-4057qib7 3946 2 14,3 14,3 CD cord-005453-4057qib7 3946 3 % % NN cord-005453-4057qib7 3946 4 ) ) -RRB- cord-005453-4057qib7 3946 5 . . . cord-005453-4057qib7 3947 1 Fourteen fourteen CD cord-005453-4057qib7 3947 2 ( ( -LRB- cord-005453-4057qib7 3947 3 60 60 CD cord-005453-4057qib7 3947 4 % % NN cord-005453-4057qib7 3947 5 ) ) -RRB- cord-005453-4057qib7 3947 6 pts pt NNS cord-005453-4057qib7 3947 7 needed need VBD cord-005453-4057qib7 3947 8 inotropic inotropic NNP cord-005453-4057qib7 3947 9 agents agent NNS cord-005453-4057qib7 3947 10 for for IN cord-005453-4057qib7 3947 11 shock shock NN cord-005453-4057qib7 3947 12 treatment treatment NN cord-005453-4057qib7 3947 13 . . . cord-005453-4057qib7 3948 1 Finally finally RB cord-005453-4057qib7 3948 2 , , , cord-005453-4057qib7 3948 3 4 4 CD cord-005453-4057qib7 3948 4 ( ( -LRB- cord-005453-4057qib7 3948 5 4,5 4,5 CD cord-005453-4057qib7 3948 6 % % NN cord-005453-4057qib7 3948 7 ) ) -RRB- cord-005453-4057qib7 3948 8 pts pt NNS cord-005453-4057qib7 3948 9 required require VBD cord-005453-4057qib7 3948 10 substitutive substitutive JJ cord-005453-4057qib7 3948 11 renal renal JJ cord-005453-4057qib7 3948 12 therapy therapy NN cord-005453-4057qib7 3948 13 with with IN cord-005453-4057qib7 3948 14 hemodialysis hemodialysis NN cord-005453-4057qib7 3948 15 or or CC cord-005453-4057qib7 3948 16 haemofiltration haemofiltration NN cord-005453-4057qib7 3948 17 ( ( -LRB- cord-005453-4057qib7 3948 18 HD HD NNP cord-005453-4057qib7 3948 19 / / SYM cord-005453-4057qib7 3948 20 HF HF NNP cord-005453-4057qib7 3948 21 ) ) -RRB- cord-005453-4057qib7 3948 22 . . . cord-005453-4057qib7 3949 1 Eleven eleven CD cord-005453-4057qib7 3949 2 ( ( -LRB- cord-005453-4057qib7 3949 3 47,8 47,8 CD cord-005453-4057qib7 3949 4 % % NN cord-005453-4057qib7 3949 5 ) ) -RRB- cord-005453-4057qib7 3950 1 out out IN cord-005453-4057qib7 3950 2 of of IN cord-005453-4057qib7 3950 3 23 23 CD cord-005453-4057qib7 3950 4 pts pt NNS cord-005453-4057qib7 3950 5 died die VBD cord-005453-4057qib7 3950 6 , , , cord-005453-4057qib7 3950 7 7 7 CD cord-005453-4057qib7 3950 8 ( ( -LRB- cord-005453-4057qib7 3950 9 63,6 63,6 CD cord-005453-4057qib7 3950 10 % % NN cord-005453-4057qib7 3950 11 ) ) -RRB- cord-005453-4057qib7 3950 12 were be VBD cord-005453-4057qib7 3950 13 male male JJ cord-005453-4057qib7 3950 14 with with IN cord-005453-4057qib7 3950 15 a a DT cord-005453-4057qib7 3950 16 median median JJ cord-005453-4057qib7 3950 17 age age NN cord-005453-4057qib7 3950 18 of of IN cord-005453-4057qib7 3950 19 55 55 CD cord-005453-4057qib7 3950 20 years year NNS cord-005453-4057qib7 3951 1 ( ( -LRB- cord-005453-4057qib7 3951 2 range range NN cord-005453-4057qib7 3951 3 : : : cord-005453-4057qib7 3951 4 24 24 CD cord-005453-4057qib7 3951 5 - - SYM cord-005453-4057qib7 3951 6 64 64 CD cord-005453-4057qib7 3951 7 ) ) -RRB- cord-005453-4057qib7 3951 8 . . . cord-005453-4057qib7 3952 1 Ten ten CD cord-005453-4057qib7 3952 2 of of IN cord-005453-4057qib7 3952 3 them -PRON- PRP cord-005453-4057qib7 3952 4 ( ( -LRB- cord-005453-4057qib7 3952 5 90,9 90,9 CD cord-005453-4057qib7 3952 6 % % NN cord-005453-4057qib7 3952 7 ) ) -RRB- cord-005453-4057qib7 3952 8 needed need VBD cord-005453-4057qib7 3952 9 IMV IMV NNP cord-005453-4057qib7 3952 10 and and CC cord-005453-4057qib7 3952 11 were be VBD cord-005453-4057qib7 3952 12 treated treat VBN cord-005453-4057qib7 3952 13 with with IN cord-005453-4057qib7 3952 14 inotropic inotropic NNP cord-005453-4057qib7 3952 15 agents agent NNS cord-005453-4057qib7 3952 16 . . . cord-005453-4057qib7 3953 1 All all DT cord-005453-4057qib7 3953 2 patients patient NNS cord-005453-4057qib7 3953 3 who who WP cord-005453-4057qib7 3953 4 required require VBD cord-005453-4057qib7 3953 5 HD HD NNP cord-005453-4057qib7 3953 6 / / SYM cord-005453-4057qib7 3953 7 HF HF NNP cord-005453-4057qib7 3953 8 ( ( -LRB- cord-005453-4057qib7 3953 9 n=4 n=4 NNP cord-005453-4057qib7 3953 10 ) ) -RRB- cord-005453-4057qib7 3953 11 died die VBD cord-005453-4057qib7 3953 12 . . . cord-005453-4057qib7 3954 1 IMV IMV NNP cord-005453-4057qib7 3954 2 and and CC cord-005453-4057qib7 3954 3 treatment treatment NN cord-005453-4057qib7 3954 4 with with IN cord-005453-4057qib7 3954 5 inotropic inotropic NNP cord-005453-4057qib7 3954 6 agents agent NNS cord-005453-4057qib7 3954 7 were be VBD cord-005453-4057qib7 3954 8 associated associate VBN cord-005453-4057qib7 3954 9 with with IN cord-005453-4057qib7 3954 10 ICU ICU NNP cord-005453-4057qib7 3954 11 mortality mortality NN cord-005453-4057qib7 3954 12 ( ( -LRB- cord-005453-4057qib7 3954 13 OR or CC cord-005453-4057qib7 3954 14 6,5 6,5 CD cord-005453-4057qib7 3954 15 ; ; : cord-005453-4057qib7 3954 16 p=0,03 p=0,03 XX cord-005453-4057qib7 3954 17 , , , cord-005453-4057qib7 3954 18 OR or CC cord-005453-4057qib7 3954 19 7 7 CD cord-005453-4057qib7 3954 20 ; ; : cord-005453-4057qib7 3954 21 p=0,008 p=0,008 NNP cord-005453-4057qib7 3954 22 ; ; : cord-005453-4057qib7 3954 23 respectively respectively RB cord-005453-4057qib7 3954 24 ) ) -RRB- cord-005453-4057qib7 3954 25 . . . cord-005453-4057qib7 3955 1 Conclusions conclusion NNS cord-005453-4057qib7 3955 2 : : : cord-005453-4057qib7 3956 1 In in IN cord-005453-4057qib7 3956 2 our -PRON- PRP$ cord-005453-4057qib7 3956 3 series series NN cord-005453-4057qib7 3956 4 of of IN cord-005453-4057qib7 3956 5 pts pts NNP cord-005453-4057qib7 3956 6 , , , cord-005453-4057qib7 3956 7 7,1 7,1 CD cord-005453-4057qib7 3956 8 % % NN cord-005453-4057qib7 3956 9 needed need VBN cord-005453-4057qib7 3956 10 admission admission NN cord-005453-4057qib7 3956 11 in in IN cord-005453-4057qib7 3956 12 the the DT cord-005453-4057qib7 3956 13 ICU ICU NNP cord-005453-4057qib7 3956 14 , , , cord-005453-4057qib7 3956 15 presenting present VBG cord-005453-4057qib7 3956 16 a a DT cord-005453-4057qib7 3956 17 mortality mortality NN cord-005453-4057qib7 3956 18 rate rate NN cord-005453-4057qib7 3956 19 of of IN cord-005453-4057qib7 3956 20 48 48 CD cord-005453-4057qib7 3956 21 % % NN cord-005453-4057qib7 3956 22 approximately approximately RB cord-005453-4057qib7 3956 23 . . . cord-005453-4057qib7 3957 1 There there EX cord-005453-4057qib7 3957 2 were be VBD cord-005453-4057qib7 3957 3 no no DT cord-005453-4057qib7 3957 4 differences difference NNS cord-005453-4057qib7 3957 5 in in IN cord-005453-4057qib7 3957 6 the the DT cord-005453-4057qib7 3957 7 prevalence prevalence NN cord-005453-4057qib7 3957 8 of of IN cord-005453-4057qib7 3957 9 ICU ICU NNP cord-005453-4057qib7 3957 10 admission admission NN cord-005453-4057qib7 3957 11 regarding regard VBG cord-005453-4057qib7 3957 12 HSCT HSCT NNP cord-005453-4057qib7 3957 13 donor donor NN cord-005453-4057qib7 3957 14 . . . cord-005453-4057qib7 3958 1 Main main JJ cord-005453-4057qib7 3958 2 reason reason NN cord-005453-4057qib7 3958 3 for for IN cord-005453-4057qib7 3958 4 admission admission NN cord-005453-4057qib7 3958 5 was be VBD cord-005453-4057qib7 3958 6 respiratory respiratory JJ cord-005453-4057qib7 3958 7 failure failure NN cord-005453-4057qib7 3958 8 with with IN cord-005453-4057qib7 3958 9 IMV IMV NNP cord-005453-4057qib7 3958 10 requirement requirement NN cord-005453-4057qib7 3958 11 in in IN cord-005453-4057qib7 3958 12 14,3 14,3 CD cord-005453-4057qib7 3958 13 % % NN cord-005453-4057qib7 3958 14 of of IN cord-005453-4057qib7 3958 15 pts pt NNS cord-005453-4057qib7 3958 16 . . . cord-005453-4057qib7 3959 1 IMV IMV NNP cord-005453-4057qib7 3959 2 and and CC cord-005453-4057qib7 3959 3 treatment treatment NN cord-005453-4057qib7 3959 4 with with IN cord-005453-4057qib7 3959 5 inotropic inotropic NNP cord-005453-4057qib7 3959 6 agents agent NNS cord-005453-4057qib7 3959 7 were be VBD cord-005453-4057qib7 3959 8 associated associate VBN cord-005453-4057qib7 3959 9 with with IN cord-005453-4057qib7 3959 10 ICU ICU NNP cord-005453-4057qib7 3959 11 mortality mortality NN cord-005453-4057qib7 3959 12 . . . cord-005453-4057qib7 3960 1 An an DT cord-005453-4057qib7 3960 2 early early JJ cord-005453-4057qib7 3960 3 identification identification NN cord-005453-4057qib7 3960 4 of of IN cord-005453-4057qib7 3960 5 pts pts NN cord-005453-4057qib7 3960 6 at at IN cord-005453-4057qib7 3960 7 risk risk NN cord-005453-4057qib7 3960 8 of of IN cord-005453-4057qib7 3960 9 ICU ICU NNP cord-005453-4057qib7 3960 10 admission admission NN cord-005453-4057qib7 3960 11 could could MD cord-005453-4057qib7 3960 12 have have VB cord-005453-4057qib7 3960 13 a a DT cord-005453-4057qib7 3960 14 beneficial beneficial JJ cord-005453-4057qib7 3960 15 impact impact NN cord-005453-4057qib7 3960 16 on on IN cord-005453-4057qib7 3960 17 survival survival NN cord-005453-4057qib7 3960 18 improvement improvement NN cord-005453-4057qib7 3960 19 Disclosure Disclosure NNP cord-005453-4057qib7 3960 20 : : : cord-005453-4057qib7 3961 1 Nothing nothing NN cord-005453-4057qib7 3961 2 to to TO cord-005453-4057qib7 3961 3 declare declare VB cord-005453-4057qib7 3961 4 Is be VBZ cord-005453-4057qib7 3961 5 there there EX cord-005453-4057qib7 3961 6 any any DT cord-005453-4057qib7 3961 7 association association NN cord-005453-4057qib7 3961 8 between between IN cord-005453-4057qib7 3961 9 thrombotic thrombotic JJ cord-005453-4057qib7 3961 10 risk risk NN cord-005453-4057qib7 3961 11 factors factor NNS cord-005453-4057qib7 3961 12 and and CC cord-005453-4057qib7 3961 13 veno veno NNP cord-005453-4057qib7 3961 14 - - HYPH cord-005453-4057qib7 3961 15 oclusive oclusive JJ cord-005453-4057qib7 3961 16 disease disease NN cord-005453-4057qib7 3961 17 in in IN cord-005453-4057qib7 3961 18 childhood childhood NN cord-005453-4057qib7 3961 19 allogeneic allogeneic IN cord-005453-4057qib7 3961 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 3961 21 stem stem NN cord-005453-4057qib7 3961 22 cell cell NN cord-005453-4057qib7 3961 23 transplantation transplantation NN cord-005453-4057qib7 3961 24 ? ? . cord-005453-4057qib7 3962 1 Background background NN cord-005453-4057qib7 3962 2 : : : cord-005453-4057qib7 3963 1 Veno Veno NNP cord-005453-4057qib7 3963 2 - - HYPH cord-005453-4057qib7 3963 3 oclusive oclusive JJ cord-005453-4057qib7 3963 4 disease disease NN cord-005453-4057qib7 3963 5 ( ( -LRB- cord-005453-4057qib7 3963 6 VOD VOD NNP cord-005453-4057qib7 3963 7 ) ) -RRB- cord-005453-4057qib7 3963 8 is be VBZ cord-005453-4057qib7 3963 9 a a DT cord-005453-4057qib7 3963 10 major major JJ cord-005453-4057qib7 3963 11 complication complication NN cord-005453-4057qib7 3963 12 of of IN cord-005453-4057qib7 3963 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 3963 14 stem stem NN cord-005453-4057qib7 3963 15 cell cell NN cord-005453-4057qib7 3963 16 transplantation transplantation NN cord-005453-4057qib7 3963 17 ( ( -LRB- cord-005453-4057qib7 3963 18 HSCT HSCT NNP cord-005453-4057qib7 3963 19 ) ) -RRB- cord-005453-4057qib7 3963 20 . . . cord-005453-4057qib7 3964 1 In in IN cord-005453-4057qib7 3964 2 some some DT cord-005453-4057qib7 3964 3 studies study NNS cord-005453-4057qib7 3964 4 levels level NNS cord-005453-4057qib7 3964 5 of of IN cord-005453-4057qib7 3964 6 fibrinolytic fibrinolytic JJ cord-005453-4057qib7 3964 7 factors factor NNS cord-005453-4057qib7 3964 8 especially especially RB cord-005453-4057qib7 3964 9 plasminogen plasminogen NN cord-005453-4057qib7 3964 10 activator activator NN cord-005453-4057qib7 3964 11 inhibitor-1 inhibitor-1 NNP cord-005453-4057qib7 3964 12 ( ( -LRB- cord-005453-4057qib7 3964 13 PAI-1 PAI-1 NNP cord-005453-4057qib7 3964 14 ) ) -RRB- cord-005453-4057qib7 3964 15 level level NN cord-005453-4057qib7 3964 16 were be VBD cord-005453-4057qib7 3964 17 found find VBN cord-005453-4057qib7 3964 18 associated associate VBN cord-005453-4057qib7 3964 19 with with IN cord-005453-4057qib7 3964 20 VOD VOD NNP cord-005453-4057qib7 3964 21 . . . cord-005453-4057qib7 3965 1 However however RB cord-005453-4057qib7 3965 2 , , , cord-005453-4057qib7 3965 3 little little JJ cord-005453-4057qib7 3965 4 is be VBZ cord-005453-4057qib7 3965 5 known know VBN cord-005453-4057qib7 3965 6 about about IN cord-005453-4057qib7 3965 7 the the DT cord-005453-4057qib7 3965 8 relationship relationship NN cord-005453-4057qib7 3965 9 between between IN cord-005453-4057qib7 3965 10 thrombophilia thrombophilia NNP cord-005453-4057qib7 3965 11 risk risk NN cord-005453-4057qib7 3965 12 factors factor NNS cord-005453-4057qib7 3965 13 and and CC cord-005453-4057qib7 3965 14 VOD vod NN cord-005453-4057qib7 3965 15 . . . cord-005453-4057qib7 3966 1 In in IN cord-005453-4057qib7 3966 2 this this DT cord-005453-4057qib7 3966 3 study study NN cord-005453-4057qib7 3966 4 we -PRON- PRP cord-005453-4057qib7 3966 5 aimed aim VBD cord-005453-4057qib7 3966 6 to to TO cord-005453-4057qib7 3966 7 investigate investigate VB cord-005453-4057qib7 3966 8 association association NNP cord-005453-4057qib7 3966 9 of of IN cord-005453-4057qib7 3966 10 major major NNP cord-005453-4057qib7 3966 11 thrombophilic thrombophilic NNP cord-005453-4057qib7 3966 12 gene gene NN cord-005453-4057qib7 3966 13 mutations mutation NNS cord-005453-4057qib7 3966 14 on on IN cord-005453-4057qib7 3966 15 VOD VOD NNP cord-005453-4057qib7 3966 16 in in IN cord-005453-4057qib7 3966 17 pediatric pediatric JJ cord-005453-4057qib7 3966 18 HSCT HSCT NNP cord-005453-4057qib7 3966 19 patients patient NNS cord-005453-4057qib7 3966 20 . . . cord-005453-4057qib7 3967 1 Methods method NNS cord-005453-4057qib7 3967 2 : : : cord-005453-4057qib7 3968 1 We -PRON- PRP cord-005453-4057qib7 3968 2 reviewed review VBD cord-005453-4057qib7 3968 3 retrospectively retrospectively RB cord-005453-4057qib7 3968 4 35 35 CD cord-005453-4057qib7 3968 5 patients patient NNS cord-005453-4057qib7 3968 6 with with IN cord-005453-4057qib7 3968 7 VOD VOD NNP cord-005453-4057qib7 3968 8 who who WP cord-005453-4057qib7 3968 9 underwent undergo VBD cord-005453-4057qib7 3968 10 HSCT HSCT NNP cord-005453-4057qib7 3968 11 between between IN cord-005453-4057qib7 3968 12 2010 2010 CD cord-005453-4057qib7 3968 13 - - SYM cord-005453-4057qib7 3968 14 2018 2018 CD cord-005453-4057qib7 3968 15 in in IN cord-005453-4057qib7 3968 16 Ankara Ankara NNP cord-005453-4057qib7 3968 17 Pediatrics Pediatrics NNP cord-005453-4057qib7 3968 18 and and CC cord-005453-4057qib7 3968 19 Pediatric Pediatric NNP cord-005453-4057qib7 3968 20 Hematology Hematology NNP cord-005453-4057qib7 3968 21 - - HYPH cord-005453-4057qib7 3968 22 Oncology Oncology NNP cord-005453-4057qib7 3968 23 Training Training NNP cord-005453-4057qib7 3968 24 and and CC cord-005453-4057qib7 3968 25 Education Education NNP cord-005453-4057qib7 3968 26 Hospital Hospital NNP cord-005453-4057qib7 3968 27 , , , cord-005453-4057qib7 3968 28 Bone Bone NNP cord-005453-4057qib7 3968 29 Marrow Marrow NNP cord-005453-4057qib7 3968 30 Transplantation Transplantation NNP cord-005453-4057qib7 3968 31 Unit Unit NNP cord-005453-4057qib7 3968 32 , , , cord-005453-4057qib7 3968 33 Turkey Turkey NNP cord-005453-4057qib7 3968 34 . . . cord-005453-4057qib7 3969 1 Fifty fifty CD cord-005453-4057qib7 3969 2 - - HYPH cord-005453-4057qib7 3969 3 one one CD cord-005453-4057qib7 3969 4 patients patient NNS cord-005453-4057qib7 3969 5 who who WP cord-005453-4057qib7 3969 6 did do VBD cord-005453-4057qib7 3969 7 not not RB cord-005453-4057qib7 3969 8 develop develop VB cord-005453-4057qib7 3969 9 VOD VOD NNP cord-005453-4057qib7 3969 10 and and CC cord-005453-4057qib7 3969 11 transplanted transplant VBN cord-005453-4057qib7 3969 12 during during IN cord-005453-4057qib7 3969 13 the the DT cord-005453-4057qib7 3969 14 study study NN cord-005453-4057qib7 3969 15 period period NN cord-005453-4057qib7 3969 16 were be VBD cord-005453-4057qib7 3969 17 accepted accept VBN cord-005453-4057qib7 3969 18 as as IN cord-005453-4057qib7 3969 19 control control NN cord-005453-4057qib7 3969 20 group group NN cord-005453-4057qib7 3969 21 . . . cord-005453-4057qib7 3970 1 We -PRON- PRP cord-005453-4057qib7 3970 2 evaluated evaluate VBD cord-005453-4057qib7 3970 3 plasma plasma NN cord-005453-4057qib7 3970 4 homocysteine homocysteine NN cord-005453-4057qib7 3970 5 and and CC cord-005453-4057qib7 3970 6 lipoprotein lipoprotein VB cord-005453-4057qib7 3970 7 a a DT cord-005453-4057qib7 3970 8 level level NN cord-005453-4057qib7 3970 9 , , , cord-005453-4057qib7 3970 10 protein protein NN cord-005453-4057qib7 3970 11 S S NNP cord-005453-4057qib7 3970 12 and and CC cord-005453-4057qib7 3970 13 C C NNP cord-005453-4057qib7 3970 14 activity activity NN cord-005453-4057qib7 3970 15 and and CC cord-005453-4057qib7 3970 16 antigen antigen NN cord-005453-4057qib7 3970 17 levels level NNS cord-005453-4057qib7 3970 18 and and CC cord-005453-4057qib7 3970 19 factor factor NN cord-005453-4057qib7 3970 20 V V NNP cord-005453-4057qib7 3970 21 G1691A G1691A NNP cord-005453-4057qib7 3970 22 mutation mutation NN cord-005453-4057qib7 3970 23 , , , cord-005453-4057qib7 3970 24 prothrombin prothrombin NN cord-005453-4057qib7 3970 25 G20210A G20210A NNP cord-005453-4057qib7 3970 26 mutation mutation NN cord-005453-4057qib7 3970 27 , , , cord-005453-4057qib7 3971 1 methylenetetrahydrofolatereductase methylenetetrahydrofolatereductase NNP cord-005453-4057qib7 3971 2 ( ( -LRB- cord-005453-4057qib7 3971 3 MTHFR MTHFR NNP cord-005453-4057qib7 3971 4 ) ) -RRB- cord-005453-4057qib7 3972 1 C677 C677 NNP cord-005453-4057qib7 3972 2 T T NNP cord-005453-4057qib7 3972 3 and and CC cord-005453-4057qib7 3972 4 A1298C A1298C NNP cord-005453-4057qib7 3972 5 mutations mutation NNS cord-005453-4057qib7 3972 6 , , , cord-005453-4057qib7 3972 7 plasminogen plasminogen NN cord-005453-4057qib7 3972 8 activator activator NN cord-005453-4057qib7 3972 9 inhibitor-1 inhibitor-1 NNP cord-005453-4057qib7 3972 10 -675 -675 NN cord-005453-4057qib7 3972 11 4G/5 4g/5 CD cord-005453-4057qib7 3972 12 G g NN cord-005453-4057qib7 3972 13 polymorphism polymorphism NN cord-005453-4057qib7 3972 14 before before IN cord-005453-4057qib7 3972 15 HSCT HSCT NNP cord-005453-4057qib7 3972 16 . . . cord-005453-4057qib7 3973 1 We -PRON- PRP cord-005453-4057qib7 3973 2 also also RB cord-005453-4057qib7 3973 3 evaluated evaluate VBD cord-005453-4057qib7 3973 4 the the DT cord-005453-4057qib7 3973 5 patients patient NNS cord-005453-4057qib7 3973 6 ' ' POS cord-005453-4057qib7 3973 7 hospital hospital NN cord-005453-4057qib7 3973 8 files file NNS cord-005453-4057qib7 3973 9 and and CC cord-005453-4057qib7 3973 10 noted note VBD cord-005453-4057qib7 3973 11 the the DT cord-005453-4057qib7 3973 12 demographic demographic JJ cord-005453-4057qib7 3973 13 values value NNS cord-005453-4057qib7 3973 14 and and CC cord-005453-4057qib7 3973 15 complications complication NNS cord-005453-4057qib7 3973 16 of of IN cord-005453-4057qib7 3973 17 HSCT HSCT NNP cord-005453-4057qib7 3973 18 . . . cord-005453-4057qib7 3974 1 Statistical statistical JJ cord-005453-4057qib7 3974 2 investigations investigation NNS cord-005453-4057qib7 3974 3 were be VBD cord-005453-4057qib7 3974 4 done do VBN cord-005453-4057qib7 3974 5 with with IN cord-005453-4057qib7 3974 6 SPSS SPSS NNP cord-005453-4057qib7 3974 7 statistics statistic NNS cord-005453-4057qib7 3974 8 17.0 17.0 CD cord-005453-4057qib7 3974 9 for for IN cord-005453-4057qib7 3974 10 windows window NNS cord-005453-4057qib7 3974 11 and and CC cord-005453-4057qib7 3974 12 p p NN cord-005453-4057qib7 3974 13 < < XX cord-005453-4057qib7 3974 14 0.05 0.05 CD cord-005453-4057qib7 3974 15 has have VBZ cord-005453-4057qib7 3974 16 been be VBN cord-005453-4057qib7 3974 17 accepted accept VBN cord-005453-4057qib7 3974 18 as as IN cord-005453-4057qib7 3974 19 significant significant JJ cord-005453-4057qib7 3974 20 . . . cord-005453-4057qib7 3975 1 Results result NNS cord-005453-4057qib7 3975 2 : : : cord-005453-4057qib7 3976 1 There there EX cord-005453-4057qib7 3976 2 was be VBD cord-005453-4057qib7 3976 3 no no DT cord-005453-4057qib7 3976 4 difference difference NN cord-005453-4057qib7 3976 5 between between IN cord-005453-4057qib7 3976 6 control control NN cord-005453-4057qib7 3976 7 and and CC cord-005453-4057qib7 3976 8 VOD VOD NNP cord-005453-4057qib7 3976 9 groups group NNS cord-005453-4057qib7 3976 10 as as IN cord-005453-4057qib7 3976 11 regard regard NN cord-005453-4057qib7 3976 12 to to IN cord-005453-4057qib7 3976 13 age age NN cord-005453-4057qib7 3976 14 , , , cord-005453-4057qib7 3976 15 sex sex NN cord-005453-4057qib7 3976 16 , , , cord-005453-4057qib7 3976 17 diagnosis diagnosis NN cord-005453-4057qib7 3976 18 , , , cord-005453-4057qib7 3976 19 donor donor NN cord-005453-4057qib7 3976 20 type type NN cord-005453-4057qib7 3976 21 , , , cord-005453-4057qib7 3976 22 conditioning conditioning NN cord-005453-4057qib7 3976 23 regimen regimen NN cord-005453-4057qib7 3976 24 , , , cord-005453-4057qib7 3976 25 HSC HSC NNP cord-005453-4057qib7 3976 26 source source NN cord-005453-4057qib7 3976 27 , , , cord-005453-4057qib7 3976 28 and and CC cord-005453-4057qib7 3976 29 HLA HLA NNP cord-005453-4057qib7 3976 30 typing typing NN cord-005453-4057qib7 3976 31 . . . cord-005453-4057qib7 3977 1 There there EX cord-005453-4057qib7 3977 2 was be VBD cord-005453-4057qib7 3977 3 no no DT cord-005453-4057qib7 3977 4 difference difference NN cord-005453-4057qib7 3977 5 between between IN cord-005453-4057qib7 3977 6 the the DT cord-005453-4057qib7 3977 7 groups group NNS cord-005453-4057qib7 3977 8 according accord VBG cord-005453-4057qib7 3977 9 to to IN cord-005453-4057qib7 3977 10 homocysteine homocysteine NN cord-005453-4057qib7 3977 11 , , , cord-005453-4057qib7 3977 12 lipoprotein lipoprotein VB cord-005453-4057qib7 3977 13 a a DT cord-005453-4057qib7 3977 14 , , , cord-005453-4057qib7 3977 15 protein protein NN cord-005453-4057qib7 3977 16 S S NNP cord-005453-4057qib7 3977 17 and and CC cord-005453-4057qib7 3977 18 C C NNP cord-005453-4057qib7 3977 19 activity activity NN cord-005453-4057qib7 3977 20 and and CC cord-005453-4057qib7 3977 21 antigen antigen NN cord-005453-4057qib7 3977 22 levels level NNS cord-005453-4057qib7 3977 23 . . . cord-005453-4057qib7 3978 1 We -PRON- PRP cord-005453-4057qib7 3978 2 did do VBD cord-005453-4057qib7 3978 3 not not RB cord-005453-4057qib7 3978 4 find find VB cord-005453-4057qib7 3978 5 any any DT cord-005453-4057qib7 3978 6 relation relation NN cord-005453-4057qib7 3978 7 between between IN cord-005453-4057qib7 3978 8 the the DT cord-005453-4057qib7 3978 9 genetic genetic JJ cord-005453-4057qib7 3978 10 variations variation NNS cord-005453-4057qib7 3978 11 of of IN cord-005453-4057qib7 3978 12 thrombophilia thrombophilia NNP cord-005453-4057qib7 3978 13 and and CC cord-005453-4057qib7 3978 14 VOD VOD NNP cord-005453-4057qib7 3978 15 ( ( -LRB- cord-005453-4057qib7 3978 16 Table Table NNP cord-005453-4057qib7 3978 17 1 1 CD cord-005453-4057qib7 3978 18 ) ) -RRB- cord-005453-4057qib7 3978 19 . . . cord-005453-4057qib7 3979 1 In in IN cord-005453-4057qib7 3979 2 VOD VOD NNP cord-005453-4057qib7 3979 3 group group NN cord-005453-4057qib7 3979 4 there there EX cord-005453-4057qib7 3979 5 were be VBD cord-005453-4057qib7 3979 6 6 6 CD cord-005453-4057qib7 3979 7 patients patient NNS cord-005453-4057qib7 3979 8 ( ( -LRB- cord-005453-4057qib7 3979 9 17.1 17.1 CD cord-005453-4057qib7 3979 10 % % NN cord-005453-4057qib7 3979 11 ) ) -RRB- cord-005453-4057qib7 3979 12 with with IN cord-005453-4057qib7 3979 13 acute acute JJ cord-005453-4057qib7 3979 14 graft graft NN cord-005453-4057qib7 3979 15 versus versus IN cord-005453-4057qib7 3979 16 host host NN cord-005453-4057qib7 3979 17 disease disease NN cord-005453-4057qib7 3979 18 ( ( -LRB- cord-005453-4057qib7 3979 19 aGVHD aGVHD NNP cord-005453-4057qib7 3979 20 ) ) -RRB- cord-005453-4057qib7 3979 21 and and CC cord-005453-4057qib7 3979 22 in in IN cord-005453-4057qib7 3979 23 control control NN cord-005453-4057qib7 3979 24 group group NN cord-005453-4057qib7 3979 25 there there EX cord-005453-4057qib7 3979 26 were be VBD cord-005453-4057qib7 3979 27 7 7 CD cord-005453-4057qib7 3979 28 ( ( -LRB- cord-005453-4057qib7 3979 29 15.9 15.9 CD cord-005453-4057qib7 3979 30 % % NN cord-005453-4057qib7 3979 31 ) ) -RRB- cord-005453-4057qib7 3979 32 patients patient NNS cord-005453-4057qib7 3979 33 with with IN cord-005453-4057qib7 3979 34 aGVHD aGVHD NNP cord-005453-4057qib7 3979 35 ( ( -LRB- cord-005453-4057qib7 3979 36 p=0.046 p=0.046 NNP cord-005453-4057qib7 3979 37 ) ) -RRB- cord-005453-4057qib7 3979 38 . . . cord-005453-4057qib7 3980 1 Febrile febrile JJ cord-005453-4057qib7 3980 2 episodes episode NNS cord-005453-4057qib7 3980 3 were be VBD cord-005453-4057qib7 3980 4 more more RBR cord-005453-4057qib7 3980 5 frequent frequent JJ cord-005453-4057qib7 3980 6 in in IN cord-005453-4057qib7 3980 7 VOD VOD NNP cord-005453-4057qib7 3980 8 group group NN cord-005453-4057qib7 3980 9 compared compare VBN cord-005453-4057qib7 3980 10 to to IN cord-005453-4057qib7 3980 11 the the DT cord-005453-4057qib7 3980 12 controls control NNS cord-005453-4057qib7 3980 13 ( ( -LRB- cord-005453-4057qib7 3980 14 respectively respectively RB cord-005453-4057qib7 3980 15 ; ; : cord-005453-4057qib7 3980 16 n=30 n=30 NNP cord-005453-4057qib7 3980 17 , , , cord-005453-4057qib7 3980 18 85.7 85.7 CD cord-005453-4057qib7 3980 19 % % NN cord-005453-4057qib7 3980 20 vs. vs. IN cord-005453-4057qib7 3980 21 n=23 n=23 NNP cord-005453-4057qib7 3980 22 , , , cord-005453-4057qib7 3980 23 54.8 54.8 CD cord-005453-4057qib7 3980 24 % % NN cord-005453-4057qib7 3980 25 , , , cord-005453-4057qib7 3980 26 p=0.006 p=0.006 NNP cord-005453-4057qib7 3980 27 ) ) -RRB- cord-005453-4057qib7 3980 28 . . . cord-005453-4057qib7 3981 1 8-year 8-year JJ cord-005453-4057qib7 3981 2 overall overall JJ cord-005453-4057qib7 3981 3 survival survival NN cord-005453-4057qib7 3981 4 was be VBD cord-005453-4057qib7 3981 5 % % NN cord-005453-4057qib7 3981 6 77.1 77.1 CD cord-005453-4057qib7 3981 7 in in IN cord-005453-4057qib7 3981 8 VOD VOD NNP cord-005453-4057qib7 3981 9 group group NN cord-005453-4057qib7 3981 10 and and CC cord-005453-4057qib7 3981 11 100 100 CD cord-005453-4057qib7 3981 12 % % NN cord-005453-4057qib7 3981 13 in in IN cord-005453-4057qib7 3981 14 control control NN cord-005453-4057qib7 3981 15 group group NN cord-005453-4057qib7 3981 16 ( ( -LRB- cord-005453-4057qib7 3981 17 p=0.001 p=0.001 NNP cord-005453-4057qib7 3981 18 ) ) -RRB- cord-005453-4057qib7 3981 19 . . . cord-005453-4057qib7 3982 1 Disease Disease NNP cord-005453-4057qib7 3982 2 free free JJ cord-005453-4057qib7 3982 3 survival survival NN cord-005453-4057qib7 3982 4 was be VBD cord-005453-4057qib7 3982 5 also also RB cord-005453-4057qib7 3982 6 different different JJ cord-005453-4057qib7 3982 7 between between IN cord-005453-4057qib7 3982 8 VOD vod NN cord-005453-4057qib7 3982 9 and and CC cord-005453-4057qib7 3982 10 control control NN cord-005453-4057qib7 3982 11 groups group NNS cord-005453-4057qib7 3982 12 ( ( -LRB- cord-005453-4057qib7 3982 13 respectively respectively RB cord-005453-4057qib7 3982 14 ; ; : cord-005453-4057qib7 3982 15 74.3 74.3 CD cord-005453-4057qib7 3982 16 % % NN cord-005453-4057qib7 3982 17 vs. vs. CC cord-005453-4057qib7 3982 18 97.3 97.3 CD cord-005453-4057qib7 3982 19 % % NN cord-005453-4057qib7 3982 20 , , , cord-005453-4057qib7 3982 21 p=0.001 p=0.001 NNP cord-005453-4057qib7 3982 22 ) ) -RRB- cord-005453-4057qib7 3982 23 . . . cord-005453-4057qib7 3983 1 Conclusions conclusion NNS cord-005453-4057qib7 3983 2 : : : cord-005453-4057qib7 3984 1 In in IN cord-005453-4057qib7 3984 2 literature literature NN cord-005453-4057qib7 3984 3 there there EX cord-005453-4057qib7 3984 4 are be VBP cord-005453-4057qib7 3984 5 recent recent JJ cord-005453-4057qib7 3984 6 studies study NNS cord-005453-4057qib7 3984 7 showing show VBG cord-005453-4057qib7 3984 8 higher high JJR cord-005453-4057qib7 3984 9 PAI-1 PAI-1 NNP cord-005453-4057qib7 3984 10 levels level NNS cord-005453-4057qib7 3984 11 in in IN cord-005453-4057qib7 3984 12 patients patient NNS cord-005453-4057qib7 3984 13 with with IN cord-005453-4057qib7 3984 14 VOD VOD NNP cord-005453-4057qib7 3984 15 . . . cord-005453-4057qib7 3985 1 However however RB cord-005453-4057qib7 3985 2 , , , cord-005453-4057qib7 3985 3 in in IN cord-005453-4057qib7 3985 4 our -PRON- PRP$ cord-005453-4057qib7 3985 5 study study NN cord-005453-4057qib7 3985 6 we -PRON- PRP cord-005453-4057qib7 3985 7 did do VBD cord-005453-4057qib7 3985 8 not not RB cord-005453-4057qib7 3985 9 find find VB cord-005453-4057qib7 3985 10 any any DT cord-005453-4057qib7 3985 11 relationship relationship NN cord-005453-4057qib7 3985 12 between between IN cord-005453-4057qib7 3985 13 congenital congenital JJ cord-005453-4057qib7 3985 14 thrombophilia thrombophilia JJ cord-005453-4057qib7 3985 15 factors factor NNS cord-005453-4057qib7 3985 16 and and CC cord-005453-4057qib7 3985 17 VOD VOD NNP cord-005453-4057qib7 3985 18 . . . cord-005453-4057qib7 3986 1 New new JJ cord-005453-4057qib7 3986 2 studies study NNS cord-005453-4057qib7 3986 3 with with IN cord-005453-4057qib7 3986 4 larger large JJR cord-005453-4057qib7 3986 5 sample sample NN cord-005453-4057qib7 3986 6 groups group NNS cord-005453-4057qib7 3986 7 is be VBZ cord-005453-4057qib7 3986 8 necessary necessary JJ cord-005453-4057qib7 3986 9 to to TO cord-005453-4057qib7 3986 10 better better RB cord-005453-4057qib7 3986 11 evaluate evaluate VB cord-005453-4057qib7 3986 12 the the DT cord-005453-4057qib7 3986 13 association association NN cord-005453-4057qib7 3986 14 of of IN cord-005453-4057qib7 3986 15 congenital congenital NNP cord-005453-4057qib7 3986 16 thrombophilia thrombophilia NNP cord-005453-4057qib7 3986 17 factors factor NNS cord-005453-4057qib7 3986 18 and and CC cord-005453-4057qib7 3986 19 VOD VOD NNP cord-005453-4057qib7 3986 20 . . . cord-005453-4057qib7 3987 1 Disclosure disclosure NN cord-005453-4057qib7 3987 2 : : : cord-005453-4057qib7 3987 3 Nothing nothing NN cord-005453-4057qib7 3987 4 to to TO cord-005453-4057qib7 3987 5 declare declare VB cord-005453-4057qib7 3987 6 P189 p189 CD cord-005453-4057qib7 3988 1 Different different JJ cord-005453-4057qib7 3988 2 strategies strategy NNS cord-005453-4057qib7 3988 3 of of IN cord-005453-4057qib7 3988 4 chemotherapy chemotherapy NN cord-005453-4057qib7 3988 5 - - HYPH cord-005453-4057qib7 3988 6 induced induce VBN cord-005453-4057qib7 3988 7 nausea nausea NN cord-005453-4057qib7 3988 8 and and CC cord-005453-4057qib7 3988 9 vomiting vomiting NN cord-005453-4057qib7 3988 10 ( ( -LRB- cord-005453-4057qib7 3988 11 CINV CINV NNP cord-005453-4057qib7 3988 12 ) ) -RRB- cord-005453-4057qib7 3988 13 prevention prevention NN cord-005453-4057qib7 3988 14 in in IN cord-005453-4057qib7 3988 15 hematological hematological JJ cord-005453-4057qib7 3988 16 patients patient NNS cord-005453-4057qib7 3988 17 receiving receive VBG cord-005453-4057qib7 3988 18 an an DT cord-005453-4057qib7 3988 19 autologous autologous JJ cord-005453-4057qib7 3988 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 3988 21 stem stem NN cord-005453-4057qib7 3988 22 cell cell NN cord-005453-4057qib7 3988 23 transplantation transplantation NN cord-005453-4057qib7 3989 1 : : : cord-005453-4057qib7 3989 2 A a DT cord-005453-4057qib7 3989 3 single single JJ cord-005453-4057qib7 3989 4 center center NN cord-005453-4057qib7 3989 5 experience experience NN cord-005453-4057qib7 3990 1 Ilaria Ilaria NNP cord-005453-4057qib7 3990 2 Cutini Cutini NNP cord-005453-4057qib7 3990 3 1 1 CD cord-005453-4057qib7 3990 4 , , , cord-005453-4057qib7 3990 5 Riccardo Riccardo NNP cord-005453-4057qib7 3990 6 Boncompagni Boncompagni NNP cord-005453-4057qib7 3990 7 1 1 CD cord-005453-4057qib7 3990 8 , , , cord-005453-4057qib7 3990 9 Chiara Chiara NNP cord-005453-4057qib7 3990 10 Nozzoli Nozzoli NNP cord-005453-4057qib7 3990 11 1 1 CD cord-005453-4057qib7 3990 12 , , , cord-005453-4057qib7 3990 13 Antonella Antonella NNP cord-005453-4057qib7 3990 14 Gozzini Gozzini NNP cord-005453-4057qib7 3990 15 1 1 CD cord-005453-4057qib7 3990 16 , , , cord-005453-4057qib7 3990 17 Stefano Stefano NNP cord-005453-4057qib7 3990 18 Guidi Guidi NNP cord-005453-4057qib7 3990 19 1 1 CD cord-005453-4057qib7 3990 20 , , , cord-005453-4057qib7 3990 21 Chiara Chiara NNP cord-005453-4057qib7 3990 22 Innocenti Innocenti NNP cord-005453-4057qib7 3990 23 1 1 CD cord-005453-4057qib7 3990 24 , , , cord-005453-4057qib7 3990 25 Massimo Massimo NNP cord-005453-4057qib7 3990 26 Di Di NNP cord-005453-4057qib7 3990 27 Gioia Gioia NNP cord-005453-4057qib7 3990 28 1 1 CD cord-005453-4057qib7 3990 29 , , , cord-005453-4057qib7 3990 30 Lorenzo Lorenzo NNP cord-005453-4057qib7 3990 31 Tofani Tofani NNP cord-005453-4057qib7 3990 32 1 1 CD cord-005453-4057qib7 3990 33 , , , cord-005453-4057qib7 3990 34 Riccardo Riccardo NNP cord-005453-4057qib7 3990 35 Saccardi Saccardi NNP cord-005453-4057qib7 3990 36 1 1 CD cord-005453-4057qib7 3990 37 Background Background NNP cord-005453-4057qib7 3990 38 : : : cord-005453-4057qib7 3991 1 Despite despite IN cord-005453-4057qib7 3991 2 the the DT cord-005453-4057qib7 3991 3 improvements improvement NNS cord-005453-4057qib7 3991 4 of of IN cord-005453-4057qib7 3991 5 pharmacological pharmacological JJ cord-005453-4057qib7 3991 6 control control NN cord-005453-4057qib7 3991 7 , , , cord-005453-4057qib7 3991 8 CINV CINV NNP cord-005453-4057qib7 3991 9 still still RB cord-005453-4057qib7 3991 10 represents represent VBZ cord-005453-4057qib7 3991 11 a a DT cord-005453-4057qib7 3991 12 major major JJ cord-005453-4057qib7 3991 13 problem problem NN cord-005453-4057qib7 3991 14 in in IN cord-005453-4057qib7 3991 15 patient patient NN cord-005453-4057qib7 3991 16 undergoing undergo VBG cord-005453-4057qib7 3991 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 3991 18 stem stem NN cord-005453-4057qib7 3991 19 cell cell NN cord-005453-4057qib7 3991 20 transplantation transplantation NN cord-005453-4057qib7 3991 21 ( ( -LRB- cord-005453-4057qib7 3991 22 HSCT HSCT NNP cord-005453-4057qib7 3991 23 ) ) -RRB- cord-005453-4057qib7 3991 24 . . . cord-005453-4057qib7 3992 1 We -PRON- PRP cord-005453-4057qib7 3992 2 present present VBP cord-005453-4057qib7 3992 3 here here RB cord-005453-4057qib7 3992 4 a a DT cord-005453-4057qib7 3992 5 comparison comparison NN cord-005453-4057qib7 3992 6 of of IN cord-005453-4057qib7 3992 7 two two CD cord-005453-4057qib7 3992 8 pharmacological pharmacological JJ cord-005453-4057qib7 3992 9 strategies strategy NNS cord-005453-4057qib7 3992 10 for for IN cord-005453-4057qib7 3992 11 preventing prevent VBG cord-005453-4057qib7 3992 12 CINV CINV NNP cord-005453-4057qib7 3992 13 in in IN cord-005453-4057qib7 3992 14 Multiple Multiple NNP cord-005453-4057qib7 3992 15 Myeloma Myeloma NNP cord-005453-4057qib7 3992 16 ( ( -LRB- cord-005453-4057qib7 3992 17 MM MM NNP cord-005453-4057qib7 3992 18 ) ) -RRB- cord-005453-4057qib7 3992 19 , , , cord-005453-4057qib7 3992 20 Hodgkin Hodgkin NNP cord-005453-4057qib7 3992 21 ( ( -LRB- cord-005453-4057qib7 3992 22 HL HL NNP cord-005453-4057qib7 3992 23 ) ) -RRB- cord-005453-4057qib7 3992 24 , , , cord-005453-4057qib7 3992 25 and and CC cord-005453-4057qib7 3992 26 Non Non NNP cord-005453-4057qib7 3992 27 - - NNP cord-005453-4057qib7 3992 28 Hodgkin Hodgkin NNP cord-005453-4057qib7 3992 29 Lymphoma Lymphoma NNP cord-005453-4057qib7 3992 30 ( ( -LRB- cord-005453-4057qib7 3992 31 NHL NHL NNP cord-005453-4057qib7 3992 32 ) ) -RRB- cord-005453-4057qib7 3992 33 patients patient NNS cord-005453-4057qib7 3992 34 who who WP cord-005453-4057qib7 3992 35 received receive VBD cord-005453-4057qib7 3992 36 an an DT cord-005453-4057qib7 3992 37 autologous autologous JJ cord-005453-4057qib7 3992 38 HSCT HSCT NNP cord-005453-4057qib7 3992 39 in in IN cord-005453-4057qib7 3992 40 our -PRON- PRP$ cord-005453-4057qib7 3992 41 Institution Institution NNP cord-005453-4057qib7 3992 42 . . . cord-005453-4057qib7 3993 1 Methods method NNS cord-005453-4057qib7 3993 2 : : : cord-005453-4057qib7 3994 1 From from IN cord-005453-4057qib7 3994 2 January January NNP cord-005453-4057qib7 3994 3 2015 2015 CD cord-005453-4057qib7 3994 4 to to IN cord-005453-4057qib7 3994 5 July July NNP cord-005453-4057qib7 3994 6 2018 2018 CD cord-005453-4057qib7 3994 7 , , , cord-005453-4057qib7 3994 8 we -PRON- PRP cord-005453-4057qib7 3994 9 retrospectively retrospectively RB cord-005453-4057qib7 3994 10 analyzed analyze VBD cord-005453-4057qib7 3994 11 250 250 CD cord-005453-4057qib7 3994 12 consecutive consecutive JJ cord-005453-4057qib7 3994 13 patients patient NNS cord-005453-4057qib7 3994 14 , , , cord-005453-4057qib7 3994 15 median median JJ cord-005453-4057qib7 3994 16 age age NN cord-005453-4057qib7 3994 17 58 58 CD cord-005453-4057qib7 3994 18 years year NNS cord-005453-4057qib7 3994 19 ( ( -LRB- cord-005453-4057qib7 3994 20 22 22 CD cord-005453-4057qib7 3994 21 - - HYPH cord-005453-4057qib7 3994 22 71yo 71yo NN cord-005453-4057qib7 3994 23 ) ) -RRB- cord-005453-4057qib7 3994 24 , , , cord-005453-4057qib7 3994 25 diagnosed diagnose VBN cord-005453-4057qib7 3994 26 with with IN cord-005453-4057qib7 3994 27 MM MM NNP cord-005453-4057qib7 3994 28 , , , cord-005453-4057qib7 3994 29 HL HL NNP cord-005453-4057qib7 3994 30 , , , cord-005453-4057qib7 3994 31 and and CC cord-005453-4057qib7 3994 32 NHL NHL NNP cord-005453-4057qib7 3994 33 , , , cord-005453-4057qib7 3994 34 who who WP cord-005453-4057qib7 3994 35 underwent undergo VBD cord-005453-4057qib7 3994 36 an an DT cord-005453-4057qib7 3994 37 autologous autologous JJ cord-005453-4057qib7 3994 38 HSCT HSCT NNP cord-005453-4057qib7 3994 39 following follow VBG cord-005453-4057qib7 3994 40 a a DT cord-005453-4057qib7 3994 41 Melphalan Melphalan NNP cord-005453-4057qib7 3994 42 200 200 CD cord-005453-4057qib7 3994 43 mg mg NNP cord-005453-4057qib7 3994 44 / / SYM cord-005453-4057qib7 3994 45 sqm sqm NN cord-005453-4057qib7 3994 46 and and CC cord-005453-4057qib7 3994 47 BEAM BEAM NNP cord-005453-4057qib7 3994 48 / / SYM cord-005453-4057qib7 3994 49 FEAM feam JJ cord-005453-4057qib7 3994 50 condition condition NN cord-005453-4057qib7 3994 51 regimens regimen NNS cord-005453-4057qib7 3994 52 , , , cord-005453-4057qib7 3994 53 respectively respectively RB cord-005453-4057qib7 3994 54 . . . cord-005453-4057qib7 3995 1 The the DT cord-005453-4057qib7 3995 2 first first JJ cord-005453-4057qib7 3995 3 122 122 CD cord-005453-4057qib7 3995 4 patients patient NNS cord-005453-4057qib7 3995 5 received receive VBD cord-005453-4057qib7 3995 6 CINV CINV NNP cord-005453-4057qib7 3995 7 prophylaxis prophylaxis NN cord-005453-4057qib7 3995 8 with with IN cord-005453-4057qib7 3995 9 palonosetron palonosetron NNP cord-005453-4057qib7 3995 10 i.v i.v NNP cord-005453-4057qib7 3995 11 and and CC cord-005453-4057qib7 3995 12 dexamethasone dexamethasone NNP cord-005453-4057qib7 3995 13 8 8 CD cord-005453-4057qib7 3995 14 mg mg NNP cord-005453-4057qib7 3995 15 die die VBP cord-005453-4057qib7 3995 16 ( ( -LRB- cord-005453-4057qib7 3995 17 Regimen regimen NN cord-005453-4057qib7 3995 18 A A NNP cord-005453-4057qib7 3995 19 ) ) -RRB- cord-005453-4057qib7 3995 20 , , , cord-005453-4057qib7 3995 21 whilst whilst IN cord-005453-4057qib7 3995 22 the the DT cord-005453-4057qib7 3995 23 following follow VBG cord-005453-4057qib7 3995 24 128 128 CD cord-005453-4057qib7 3995 25 were be VBD cord-005453-4057qib7 3995 26 administered administer VBN cord-005453-4057qib7 3995 27 with with IN cord-005453-4057qib7 3995 28 fosaprepitant fosaprepitant JJ cord-005453-4057qib7 3995 29 iv iv NNP cord-005453-4057qib7 3995 30 , , , cord-005453-4057qib7 3995 31 ondansetron ondansetron NNP cord-005453-4057qib7 3995 32 iv iv CD cord-005453-4057qib7 3995 33 and and CC cord-005453-4057qib7 3995 34 dexamethasone dexamethasone NNP cord-005453-4057qib7 3995 35 8 8 CD cord-005453-4057qib7 3995 36 mg mg NNP cord-005453-4057qib7 3995 37 die die VBP cord-005453-4057qib7 3995 38 ( ( -LRB- cord-005453-4057qib7 3995 39 Regimen regimen NN cord-005453-4057qib7 3995 40 B b NN cord-005453-4057qib7 3995 41 ) ) -RRB- cord-005453-4057qib7 3996 1 Both both DT cord-005453-4057qib7 3996 2 CINV CINV NNP cord-005453-4057qib7 3996 3 prophylaxis prophylaxis NN cord-005453-4057qib7 3996 4 was be VBD cord-005453-4057qib7 3996 5 administered administer VBN cord-005453-4057qib7 3996 6 the the DT cord-005453-4057qib7 3996 7 day day NN cord-005453-4057qib7 3996 8 of of IN cord-005453-4057qib7 3996 9 melphalan melphalan NNP cord-005453-4057qib7 3996 10 infusion infusion NNP cord-005453-4057qib7 3996 11 ( ( -LRB- cord-005453-4057qib7 3996 12 day day NN cord-005453-4057qib7 3996 13 -1 -1 CD cord-005453-4057qib7 3996 14 form form NN cord-005453-4057qib7 3996 15 transplant transplant NN cord-005453-4057qib7 3996 16 ) ) -RRB- cord-005453-4057qib7 3996 17 . . . cord-005453-4057qib7 3997 1 Emesis emesis NN cord-005453-4057qib7 3997 2 breakthroughs breakthrough NNS cord-005453-4057qib7 3997 3 were be VBD cord-005453-4057qib7 3997 4 treated treat VBN cord-005453-4057qib7 3997 5 with with IN cord-005453-4057qib7 3997 6 alizapride alizapride NN cord-005453-4057qib7 3997 7 and and CC cord-005453-4057qib7 3997 8 metoclopramide metoclopramide NN cord-005453-4057qib7 3997 9 . . . cord-005453-4057qib7 3998 1 Nausea nausea NN cord-005453-4057qib7 3998 2 and and CC cord-005453-4057qib7 3998 3 vomiting vomiting NN cord-005453-4057qib7 3998 4 were be VBD cord-005453-4057qib7 3998 5 assessed assess VBN cord-005453-4057qib7 3998 6 through through IN cord-005453-4057qib7 3998 7 the the DT cord-005453-4057qib7 3998 8 CTCAE CTCAE NNP cord-005453-4057qib7 3998 9 4.0 4.0 CD cord-005453-4057qib7 3998 10 score score NN cord-005453-4057qib7 3998 11 system system NN cord-005453-4057qib7 3998 12 . . . cord-005453-4057qib7 3999 1 Categorical categorical JJ cord-005453-4057qib7 3999 2 variables variable NNS cord-005453-4057qib7 3999 3 were be VBD cord-005453-4057qib7 3999 4 compared compare VBN cord-005453-4057qib7 3999 5 with with IN cord-005453-4057qib7 3999 6 Pearson Pearson NNP cord-005453-4057qib7 3999 7 Chi Chi NNP cord-005453-4057qib7 3999 8 - - HYPH cord-005453-4057qib7 3999 9 square square JJ cord-005453-4057qib7 3999 10 test test NN cord-005453-4057qib7 3999 11 . . . cord-005453-4057qib7 4000 1 Results result NNS cord-005453-4057qib7 4000 2 : : : cord-005453-4057qib7 4001 1 The the DT cord-005453-4057qib7 4001 2 overall overall JJ cord-005453-4057qib7 4001 3 incidence incidence NN cord-005453-4057qib7 4001 4 of of IN cord-005453-4057qib7 4001 5 nausea nausea NN cord-005453-4057qib7 4001 6 was be VBD cord-005453-4057qib7 4001 7 78 78 CD cord-005453-4057qib7 4001 8 % % NN cord-005453-4057qib7 4001 9 , , , cord-005453-4057qib7 4001 10 ( ( -LRB- cord-005453-4057qib7 4001 11 55 55 CD cord-005453-4057qib7 4001 12 % % NN cord-005453-4057qib7 4001 13 grade grade NN cord-005453-4057qib7 4001 14 1 1 CD cord-005453-4057qib7 4001 15 , , , cord-005453-4057qib7 4001 16 41 41 CD cord-005453-4057qib7 4001 17 % % NN cord-005453-4057qib7 4001 18 grade grade NN cord-005453-4057qib7 4001 19 2 2 CD cord-005453-4057qib7 4001 20 , , , cord-005453-4057qib7 4001 21 and and CC cord-005453-4057qib7 4001 22 4 4 CD cord-005453-4057qib7 4001 23 % % NN cord-005453-4057qib7 4001 24 grade grade NN cord-005453-4057qib7 4001 25 3 3 CD cord-005453-4057qib7 4001 26 , , , cord-005453-4057qib7 4001 27 respectively respectively RB cord-005453-4057qib7 4001 28 ) ) -RRB- cord-005453-4057qib7 4001 29 . . . cord-005453-4057qib7 4002 1 In in IN cord-005453-4057qib7 4002 2 Regimen Regimen NNP cord-005453-4057qib7 4002 3 A A NNP cord-005453-4057qib7 4002 4 was be VBD cord-005453-4057qib7 4002 5 shown show VBN cord-005453-4057qib7 4002 6 to to TO cord-005453-4057qib7 4002 7 be be VB cord-005453-4057qib7 4002 8 80 80 CD cord-005453-4057qib7 4002 9 % % NN cord-005453-4057qib7 4002 10 , , , cord-005453-4057qib7 4002 11 ( ( -LRB- cord-005453-4057qib7 4002 12 56 56 CD cord-005453-4057qib7 4002 13 % % NN cord-005453-4057qib7 4002 14 grade1 grade1 NN cord-005453-4057qib7 4002 15 , , , cord-005453-4057qib7 4002 16 41 41 CD cord-005453-4057qib7 4002 17 % % NN cord-005453-4057qib7 4002 18 grade grade NN cord-005453-4057qib7 4002 19 2 2 CD cord-005453-4057qib7 4002 20 , , , cord-005453-4057qib7 4002 21 and and CC cord-005453-4057qib7 4002 22 3 3 CD cord-005453-4057qib7 4002 23 % % NN cord-005453-4057qib7 4002 24 grade grade NN cord-005453-4057qib7 4002 25 3 3 CD cord-005453-4057qib7 4002 26 , , , cord-005453-4057qib7 4002 27 respectively respectively RB cord-005453-4057qib7 4002 28 ) ) -RRB- cord-005453-4057qib7 4002 29 while while IN cord-005453-4057qib7 4002 30 in in IN cord-005453-4057qib7 4002 31 Regimen Regimen NNP cord-005453-4057qib7 4002 32 B B NNP cord-005453-4057qib7 4002 33 was be VBD cord-005453-4057qib7 4002 34 77 77 CD cord-005453-4057qib7 4002 35 % % NN cord-005453-4057qib7 4002 36 ( ( -LRB- cord-005453-4057qib7 4002 37 54 54 CD cord-005453-4057qib7 4002 38 % % NN cord-005453-4057qib7 4002 39 grade grade NN cord-005453-4057qib7 4002 40 1 1 CD cord-005453-4057qib7 4002 41 , , , cord-005453-4057qib7 4002 42 41 41 CD cord-005453-4057qib7 4002 43 % % NN cord-005453-4057qib7 4002 44 grade grade NN cord-005453-4057qib7 4002 45 2 2 CD cord-005453-4057qib7 4002 46 , , , cord-005453-4057qib7 4002 47 and and CC cord-005453-4057qib7 4002 48 5 5 CD cord-005453-4057qib7 4002 49 % % NN cord-005453-4057qib7 4002 50 grade grade NN cord-005453-4057qib7 4002 51 3 3 CD cord-005453-4057qib7 4002 52 , , , cord-005453-4057qib7 4002 53 respectively respectively RB cord-005453-4057qib7 4002 54 ) ) -RRB- cord-005453-4057qib7 4002 55 . . . cord-005453-4057qib7 4003 1 Pearson Pearson NNP cord-005453-4057qib7 4003 2 Chi Chi NNP cord-005453-4057qib7 4003 3 - - HYPH cord-005453-4057qib7 4003 4 square square JJ cord-005453-4057qib7 4003 5 test test NN cord-005453-4057qib7 4003 6 did do VBD cord-005453-4057qib7 4003 7 not not RB cord-005453-4057qib7 4003 8 show show VB cord-005453-4057qib7 4003 9 any any DT cord-005453-4057qib7 4003 10 differences difference NNS cord-005453-4057qib7 4003 11 between between IN cord-005453-4057qib7 4003 12 the the DT cord-005453-4057qib7 4003 13 2 2 CD cord-005453-4057qib7 4003 14 groups group NNS cord-005453-4057qib7 4003 15 ( ( -LRB- cord-005453-4057qib7 4003 16 p=0.679 p=0.679 NN cord-005453-4057qib7 4003 17 ) ) -RRB- cord-005453-4057qib7 4003 18 . . . cord-005453-4057qib7 4004 1 The the DT cord-005453-4057qib7 4004 2 overall overall JJ cord-005453-4057qib7 4004 3 observed observed JJ cord-005453-4057qib7 4004 4 vomit vomit NN cord-005453-4057qib7 4004 5 was be VBD cord-005453-4057qib7 4004 6 32 32 CD cord-005453-4057qib7 4004 7 % % NN cord-005453-4057qib7 4004 8 ( ( -LRB- cord-005453-4057qib7 4004 9 83 83 CD cord-005453-4057qib7 4004 10 % % NN cord-005453-4057qib7 4004 11 grade grade NN cord-005453-4057qib7 4004 12 1 1 CD cord-005453-4057qib7 4004 13 , , , cord-005453-4057qib7 4004 14 16 16 CD cord-005453-4057qib7 4004 15 % % NN cord-005453-4057qib7 4004 16 grade grade NN cord-005453-4057qib7 4004 17 2 2 CD cord-005453-4057qib7 4004 18 , , , cord-005453-4057qib7 4004 19 and and CC cord-005453-4057qib7 4004 20 1 1 CD cord-005453-4057qib7 4004 21 % % NN cord-005453-4057qib7 4004 22 grade grade NN cord-005453-4057qib7 4004 23 3 3 CD cord-005453-4057qib7 4004 24 ) ) -RRB- cord-005453-4057qib7 4004 25 . . . cord-005453-4057qib7 4005 1 In in IN cord-005453-4057qib7 4005 2 Regimen regimen NN cord-005453-4057qib7 4005 3 A A NNP cord-005453-4057qib7 4005 4 it -PRON- PRP cord-005453-4057qib7 4005 5 was be VBD cord-005453-4057qib7 4005 6 ( ( -LRB- cord-005453-4057qib7 4005 7 47 47 CD cord-005453-4057qib7 4005 8 % % NN cord-005453-4057qib7 4005 9 ( ( -LRB- cord-005453-4057qib7 4005 10 84 84 CD cord-005453-4057qib7 4005 11 % % NN cord-005453-4057qib7 4005 12 grade grade NN cord-005453-4057qib7 4005 13 14 14 CD cord-005453-4057qib7 4005 14 % % NN cord-005453-4057qib7 4005 15 grade grade NN cord-005453-4057qib7 4005 16 2 2 CD cord-005453-4057qib7 4005 17 , , , cord-005453-4057qib7 4005 18 and and CC cord-005453-4057qib7 4005 19 2 2 CD cord-005453-4057qib7 4005 20 % % NN cord-005453-4057qib7 4005 21 grade grade NN cord-005453-4057qib7 4005 22 3 3 CD cord-005453-4057qib7 4005 23 ) ) -RRB- cord-005453-4057qib7 4005 24 , , , cord-005453-4057qib7 4005 25 and and CC cord-005453-4057qib7 4005 26 17 17 CD cord-005453-4057qib7 4005 27 % % NN cord-005453-4057qib7 4005 28 in in IN cord-005453-4057qib7 4005 29 Regimen Regimen NNP cord-005453-4057qib7 4005 30 B B NNP cord-005453-4057qib7 4005 31 ( ( -LRB- cord-005453-4057qib7 4005 32 77 77 CD cord-005453-4057qib7 4005 33 % % NN cord-005453-4057qib7 4005 34 grade grade NN cord-005453-4057qib7 4005 35 1 1 CD cord-005453-4057qib7 4005 36 and and CC cord-005453-4057qib7 4005 37 23 23 CD cord-005453-4057qib7 4005 38 % % NN cord-005453-4057qib7 4005 39 grade grade NN cord-005453-4057qib7 4005 40 2 2 CD cord-005453-4057qib7 4005 41 ) ) -RRB- cord-005453-4057qib7 4005 42 . . . cord-005453-4057qib7 4006 1 Conditioning conditioning NN cord-005453-4057qib7 4006 2 regimens regimen NNS cord-005453-4057qib7 4006 3 did do VBD cord-005453-4057qib7 4006 4 n't not RB cord-005453-4057qib7 4006 5 ' ' '' cord-005453-4057qib7 4006 6 have have VB cord-005453-4057qib7 4006 7 any any DT cord-005453-4057qib7 4006 8 significant significant JJ cord-005453-4057qib7 4006 9 impact impact NN cord-005453-4057qib7 4006 10 on on IN cord-005453-4057qib7 4006 11 either either CC cord-005453-4057qib7 4006 12 nausea nausea NN cord-005453-4057qib7 4006 13 or or CC cord-005453-4057qib7 4006 14 vomit vomit NN cord-005453-4057qib7 4006 15 . . . cord-005453-4057qib7 4007 1 Patientsyounger Patientsyounger NNP cord-005453-4057qib7 4007 2 then then RB cord-005453-4057qib7 4007 3 median median NN cord-005453-4057qib7 4007 4 ( ( -LRB- cord-005453-4057qib7 4007 5 58 58 CD cord-005453-4057qib7 4007 6 yrs yr NNS cord-005453-4057qib7 4007 7 ) ) -RRB- cord-005453-4057qib7 4007 8 , , , cord-005453-4057qib7 4007 9 were be VBD cord-005453-4057qib7 4007 10 reported report VBN cord-005453-4057qib7 4007 11 to to TO cord-005453-4057qib7 4007 12 have have VB cord-005453-4057qib7 4007 13 higher high JJR cord-005453-4057qib7 4007 14 incidence incidence NN cord-005453-4057qib7 4007 15 of of IN cord-005453-4057qib7 4007 16 both both DT cord-005453-4057qib7 4007 17 nausea nausea NN cord-005453-4057qib7 4007 18 , , , cord-005453-4057qib7 4007 19 ( ( -LRB- cord-005453-4057qib7 4007 20 p=0.028 p=0.028 NN cord-005453-4057qib7 4007 21 ) ) -RRB- cord-005453-4057qib7 4008 1 not not RB cord-005453-4057qib7 4008 2 related relate VBN cord-005453-4057qib7 4008 3 to to IN cord-005453-4057qib7 4008 4 CINV CINV NNP cord-005453-4057qib7 4008 5 treatment treatment NN cord-005453-4057qib7 4008 6 , , , cord-005453-4057qib7 4008 7 and and CC cord-005453-4057qib7 4008 8 vomit vomit NN cord-005453-4057qib7 4008 9 ( ( -LRB- cord-005453-4057qib7 4008 10 40 40 CD cord-005453-4057qib7 4008 11 % % NN cord-005453-4057qib7 4008 12 vs vs IN cord-005453-4057qib7 4008 13 24 24 CD cord-005453-4057qib7 4008 14 % % NN cord-005453-4057qib7 4008 15 , , , cord-005453-4057qib7 4008 16 p=0.012 p=0.012 NNP cord-005453-4057qib7 4008 17 ) ) -RRB- cord-005453-4057qib7 4008 18 . . . cord-005453-4057qib7 4009 1 In in IN cord-005453-4057qib7 4009 2 multivariate multivariate JJ cord-005453-4057qib7 4009 3 analysis analysis NN cord-005453-4057qib7 4009 4 the the DT cord-005453-4057qib7 4009 5 overall overall JJ cord-005453-4057qib7 4009 6 incidence incidence NN cord-005453-4057qib7 4009 7 of of IN cord-005453-4057qib7 4009 8 nausea nausea NN cord-005453-4057qib7 4009 9 is be VBZ cord-005453-4057qib7 4009 10 related relate VBN cord-005453-4057qib7 4009 11 to to IN cord-005453-4057qib7 4009 12 age age NN cord-005453-4057qib7 4009 13 ( ( -LRB- cord-005453-4057qib7 4009 14 younger young JJR cord-005453-4057qib7 4009 15 patients patient NNS cord-005453-4057qib7 4009 16 have have VBP cord-005453-4057qib7 4009 17 higher high JJR cord-005453-4057qib7 4009 18 probability probability NN cord-005453-4057qib7 4009 19 to to TO cord-005453-4057qib7 4009 20 develop develop VB cord-005453-4057qib7 4009 21 nausea nausea NN cord-005453-4057qib7 4009 22 ( ( -LRB- cord-005453-4057qib7 4009 23 OR or CC cord-005453-4057qib7 4009 24 2,282 2,282 CD cord-005453-4057qib7 4009 25 ; ; : cord-005453-4057qib7 4009 26 p= p= VB cord-005453-4057qib7 4009 27 0,024 0,024 CD cord-005453-4057qib7 4009 28 ) ) -RRB- cord-005453-4057qib7 4010 1 whilst whilst IN cord-005453-4057qib7 4010 2 the the DT cord-005453-4057qib7 4010 3 higher high JJR cord-005453-4057qib7 4010 4 incidence incidence NN cord-005453-4057qib7 4010 5 of of IN cord-005453-4057qib7 4010 6 vomit vomit NN cord-005453-4057qib7 4010 7 is be VBZ cord-005453-4057qib7 4010 8 related relate VBN cord-005453-4057qib7 4010 9 to to IN cord-005453-4057qib7 4010 10 : : : cord-005453-4057qib7 4010 11 Regimen regimen NN cord-005453-4057qib7 4010 12 A a NN cord-005453-4057qib7 4010 13 ( ( -LRB- cord-005453-4057qib7 4010 14 OR or NN cord-005453-4057qib7 4010 15 3.958 3.958 CD cord-005453-4057qib7 4010 16 ; ; : cord-005453-4057qib7 4010 17 p p NN cord-005453-4057qib7 4010 18 < < XX cord-005453-4057qib7 4010 19 0,001 0,001 CD cord-005453-4057qib7 4010 20 ) ) -RRB- cord-005453-4057qib7 4010 21 , , , cord-005453-4057qib7 4010 22 previously previously RB cord-005453-4057qib7 4010 23 reported report VBD cord-005453-4057qib7 4010 24 nausea nausea NN cord-005453-4057qib7 4010 25 ( ( -LRB- cord-005453-4057qib7 4010 26 OR or CC cord-005453-4057qib7 4010 27 4,506 4,506 CD cord-005453-4057qib7 4010 28 ; ; : cord-005453-4057qib7 4010 29 p p NN cord-005453-4057qib7 4010 30 < < XX cord-005453-4057qib7 4010 31 0,001 0,001 CD cord-005453-4057qib7 4010 32 ) ) -RRB- cord-005453-4057qib7 4010 33 , , , cord-005453-4057qib7 4010 34 and and CC cord-005453-4057qib7 4010 35 no no DT cord-005453-4057qib7 4010 36 smoking smoking NN cord-005453-4057qib7 4010 37 habits habit NNS cord-005453-4057qib7 4010 38 ( ( -LRB- cord-005453-4057qib7 4010 39 OR or CC cord-005453-4057qib7 4010 40 2,761 2,761 CD cord-005453-4057qib7 4010 41 ; ; : cord-005453-4057qib7 4010 42 p=0,02 p=0,02 ADD cord-005453-4057qib7 4010 43 ) ) -RRB- cord-005453-4057qib7 4010 44 . . . cord-005453-4057qib7 4011 1 Conclusions conclusion NNS cord-005453-4057qib7 4011 2 : : : cord-005453-4057qib7 4012 1 Both both DT cord-005453-4057qib7 4012 2 regimens regimen NNS cord-005453-4057qib7 4012 3 are be VBP cord-005453-4057qib7 4012 4 equally equally RB cord-005453-4057qib7 4012 5 effective effective JJ cord-005453-4057qib7 4012 6 for for IN cord-005453-4057qib7 4012 7 nausea nausea NN cord-005453-4057qib7 4012 8 control control NN cord-005453-4057qib7 4013 1 however however RB cord-005453-4057qib7 4013 2 Regimen Regimen NNP cord-005453-4057qib7 4013 3 B B NNP cord-005453-4057qib7 4013 4 evidenced evidence VBD cord-005453-4057qib7 4013 5 a a DT cord-005453-4057qib7 4013 6 better well JJR cord-005453-4057qib7 4013 7 vomiting vomiting NN cord-005453-4057qib7 4013 8 control control NN cord-005453-4057qib7 4013 9 . . . cord-005453-4057qib7 4014 1 This this DT cord-005453-4057qib7 4014 2 finding finding NN cord-005453-4057qib7 4014 3 is be VBZ cord-005453-4057qib7 4014 4 particularly particularly RB cord-005453-4057qib7 4014 5 relevant relevant JJ cord-005453-4057qib7 4014 6 when when WRB cord-005453-4057qib7 4014 7 the the DT cord-005453-4057qib7 4014 8 Center Center NNP cord-005453-4057qib7 4014 9 policies policy NNS cord-005453-4057qib7 4014 10 include include VBP cord-005453-4057qib7 4014 11 an an DT cord-005453-4057qib7 4014 12 early early JJ cord-005453-4057qib7 4014 13 discharge discharge NN cord-005453-4057qib7 4014 14 program program NN cord-005453-4057qib7 4014 15 , , , cord-005453-4057qib7 4014 16 therefore therefore RB cord-005453-4057qib7 4014 17 improving improve VBG cord-005453-4057qib7 4014 18 both both DT cord-005453-4057qib7 4014 19 patient patient NN cord-005453-4057qib7 4014 20 's 's POS cord-005453-4057qib7 4014 21 Quality Quality NNP cord-005453-4057qib7 4014 22 of of IN cord-005453-4057qib7 4014 23 Life Life NNP cord-005453-4057qib7 4014 24 and and CC cord-005453-4057qib7 4014 25 procedure procedure NN cord-005453-4057qib7 4014 26 cost cost NN cord-005453-4057qib7 4014 27 - - HYPH cord-005453-4057qib7 4014 28 effectiveness effectiveness NN cord-005453-4057qib7 4014 29 . . . cord-005453-4057qib7 4015 1 Clinical clinical JJ cord-005453-4057qib7 4015 2 Background background NN cord-005453-4057qib7 4015 3 : : : cord-005453-4057qib7 4016 1 Patients patient NNS cord-005453-4057qib7 4016 2 who who WP cord-005453-4057qib7 4016 3 underwent undergo VBD cord-005453-4057qib7 4016 4 an an DT cord-005453-4057qib7 4016 5 allogeneic allogeneic JJ cord-005453-4057qib7 4016 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 4016 7 cell cell NN cord-005453-4057qib7 4016 8 transplantation transplantation NN cord-005453-4057qib7 4016 9 ( ( -LRB- cord-005453-4057qib7 4016 10 HCT HCT NNP cord-005453-4057qib7 4016 11 ) ) -RRB- cord-005453-4057qib7 4016 12 are be VBP cord-005453-4057qib7 4016 13 challenged challenge VBN cord-005453-4057qib7 4016 14 by by IN cord-005453-4057qib7 4016 15 medical medical JJ cord-005453-4057qib7 4016 16 , , , cord-005453-4057qib7 4016 17 psychological psychological JJ cord-005453-4057qib7 4016 18 and and CC cord-005453-4057qib7 4016 19 social social JJ cord-005453-4057qib7 4016 20 complications complication NNS cord-005453-4057qib7 4016 21 . . . cord-005453-4057qib7 4017 1 Support support NN cord-005453-4057qib7 4017 2 groups group NNS cord-005453-4057qib7 4017 3 might may MD cord-005453-4057qib7 4017 4 help help VB cord-005453-4057qib7 4017 5 HCT hct NN cord-005453-4057qib7 4017 6 - - HYPH cord-005453-4057qib7 4017 7 survivors survivor NNS cord-005453-4057qib7 4017 8 to to TO cord-005453-4057qib7 4017 9 cope cope VB cord-005453-4057qib7 4017 10 with with IN cord-005453-4057qib7 4017 11 these these DT cord-005453-4057qib7 4017 12 challenges challenge NNS cord-005453-4057qib7 4017 13 . . . cord-005453-4057qib7 4018 1 However however RB cord-005453-4057qib7 4018 2 , , , cord-005453-4057qib7 4018 3 the the DT cord-005453-4057qib7 4018 4 existing exist VBG cord-005453-4057qib7 4018 5 literature literature NN cord-005453-4057qib7 4018 6 about about IN cord-005453-4057qib7 4018 7 post post JJ cord-005453-4057qib7 4018 8 - - JJ cord-005453-4057qib7 4018 9 HCT hct JJ cord-005453-4057qib7 4018 10 support support NN cord-005453-4057qib7 4018 11 groups group NNS cord-005453-4057qib7 4018 12 is be VBZ cord-005453-4057qib7 4018 13 scarce scarce JJ cord-005453-4057qib7 4018 14 . . . cord-005453-4057qib7 4019 1 Moreover moreover RB cord-005453-4057qib7 4019 2 , , , cord-005453-4057qib7 4019 3 data datum NNS cord-005453-4057qib7 4019 4 on on IN cord-005453-4057qib7 4019 5 professionallyfacilitated professionallyfacilitated JJ cord-005453-4057qib7 4019 6 support support NN cord-005453-4057qib7 4019 7 groups group NNS cord-005453-4057qib7 4019 8 do do VBP cord-005453-4057qib7 4019 9 not not RB cord-005453-4057qib7 4019 10 exist exist VB cord-005453-4057qib7 4019 11 . . . cord-005453-4057qib7 4020 1 The the DT cord-005453-4057qib7 4020 2 aim aim NN cord-005453-4057qib7 4020 3 of of IN cord-005453-4057qib7 4020 4 this this DT cord-005453-4057qib7 4020 5 project project NN cord-005453-4057qib7 4020 6 was be VBD cord-005453-4057qib7 4020 7 ( ( -LRB- cord-005453-4057qib7 4020 8 1 1 CD cord-005453-4057qib7 4020 9 ) ) -RRB- cord-005453-4057qib7 4020 10 to to TO cord-005453-4057qib7 4020 11 establish establish VB cord-005453-4057qib7 4020 12 a a DT cord-005453-4057qib7 4020 13 professionally professionally RB cord-005453-4057qib7 4020 14 - - HYPH cord-005453-4057qib7 4020 15 facilitated facilitate VBN cord-005453-4057qib7 4020 16 support support NN cord-005453-4057qib7 4020 17 group group NN cord-005453-4057qib7 4020 18 and and CC cord-005453-4057qib7 4020 19 ( ( -LRB- cord-005453-4057qib7 4020 20 2 2 LS cord-005453-4057qib7 4020 21 ) ) -RRB- cord-005453-4057qib7 4020 22 to to TO cord-005453-4057qib7 4020 23 assess assess VB cord-005453-4057qib7 4020 24 the the DT cord-005453-4057qib7 4020 25 discussed discuss VBN cord-005453-4057qib7 4020 26 topics topic NNS cord-005453-4057qib7 4020 27 . . . cord-005453-4057qib7 4021 1 Methods method NNS cord-005453-4057qib7 4021 2 : : : cord-005453-4057qib7 4022 1 From from IN cord-005453-4057qib7 4022 2 11/2013 11/2013 CD cord-005453-4057qib7 4022 3 until until IN cord-005453-4057qib7 4022 4 6/2017 6/2017 NNP cord-005453-4057qib7 4022 5 all all DT cord-005453-4057qib7 4022 6 patients patient NNS cord-005453-4057qib7 4022 7 who who WP cord-005453-4057qib7 4022 8 received receive VBD cord-005453-4057qib7 4022 9 an an DT cord-005453-4057qib7 4022 10 allogeneic allogeneic NN cord-005453-4057qib7 4022 11 HCT hct NN cord-005453-4057qib7 4022 12 at at IN cord-005453-4057qib7 4022 13 the the DT cord-005453-4057qib7 4022 14 adult adult NN cord-005453-4057qib7 4022 15 stem stem NN cord-005453-4057qib7 4022 16 cell cell NN cord-005453-4057qib7 4022 17 transplantation transplantation NN cord-005453-4057qib7 4022 18 program program NN cord-005453-4057qib7 4022 19 of of IN cord-005453-4057qib7 4022 20 the the DT cord-005453-4057qib7 4022 21 University University NNP cord-005453-4057qib7 4022 22 clinic clinic NN cord-005453-4057qib7 4022 23 Mannheim Mannheim NNP cord-005453-4057qib7 4022 24 were be VBD cord-005453-4057qib7 4022 25 invited invite VBN cord-005453-4057qib7 4022 26 to to TO cord-005453-4057qib7 4022 27 participate participate VB cord-005453-4057qib7 4022 28 in in IN cord-005453-4057qib7 4022 29 a a DT cord-005453-4057qib7 4022 30 professionally professionally RB cord-005453-4057qib7 4022 31 - - HYPH cord-005453-4057qib7 4022 32 facilitated facilitate VBN cord-005453-4057qib7 4022 33 support support NN cord-005453-4057qib7 4022 34 group group NN cord-005453-4057qib7 4022 35 . . . cord-005453-4057qib7 4023 1 Additionally additionally RB cord-005453-4057qib7 4023 2 , , , cord-005453-4057qib7 4023 3 spouses spouse NNS cord-005453-4057qib7 4023 4 and and CC cord-005453-4057qib7 4023 5 life life NN cord-005453-4057qib7 4023 6 partners partner NNS cord-005453-4057qib7 4023 7 were be VBD cord-005453-4057qib7 4023 8 invited invite VBN cord-005453-4057qib7 4023 9 . . . cord-005453-4057qib7 4024 1 A a DT cord-005453-4057qib7 4024 2 theologian theologian NN cord-005453-4057qib7 4024 3 who who WP cord-005453-4057qib7 4024 4 is be VBZ cord-005453-4057qib7 4024 5 also also RB cord-005453-4057qib7 4024 6 a a DT cord-005453-4057qib7 4024 7 physician physician NN cord-005453-4057qib7 4024 8 served serve VBD cord-005453-4057qib7 4024 9 as as IN cord-005453-4057qib7 4024 10 facilitator facilitator NN cord-005453-4057qib7 4024 11 . . . cord-005453-4057qib7 4025 1 He -PRON- PRP cord-005453-4057qib7 4025 2 had have VBD cord-005453-4057qib7 4025 3 no no DT cord-005453-4057qib7 4025 4 further further JJ cord-005453-4057qib7 4025 5 function function NN cord-005453-4057qib7 4025 6 within within IN cord-005453-4057qib7 4025 7 the the DT cord-005453-4057qib7 4025 8 transplant transplant NN cord-005453-4057qib7 4025 9 team team NN cord-005453-4057qib7 4025 10 . . . cord-005453-4057qib7 4026 1 The the DT cord-005453-4057qib7 4026 2 format format NN cord-005453-4057qib7 4026 3 of of IN cord-005453-4057qib7 4026 4 the the DT cord-005453-4057qib7 4026 5 group group NN cord-005453-4057qib7 4026 6 was be VBD cord-005453-4057qib7 4026 7 unstructured unstructured JJ cord-005453-4057qib7 4026 8 without without IN cord-005453-4057qib7 4026 9 any any DT cord-005453-4057qib7 4026 10 rules rule NNS cord-005453-4057qib7 4026 11 regarding regard VBG cord-005453-4057qib7 4026 12 regular regular JJ cord-005453-4057qib7 4026 13 attendance attendance NN cord-005453-4057qib7 4026 14 . . . cord-005453-4057qib7 4027 1 The the DT cord-005453-4057qib7 4027 2 facilitator facilitator NN cord-005453-4057qib7 4027 3 did do VBD cord-005453-4057qib7 4027 4 not not RB cord-005453-4057qib7 4027 5 provide provide VB cord-005453-4057qib7 4027 6 topics topic NNS cord-005453-4057qib7 4027 7 or or CC cord-005453-4057qib7 4027 8 a a DT cord-005453-4057qib7 4027 9 curriculum curriculum NN cord-005453-4057qib7 4027 10 . . . cord-005453-4057qib7 4028 1 During during IN cord-005453-4057qib7 4028 2 the the DT cord-005453-4057qib7 4028 3 first first JJ cord-005453-4057qib7 4028 4 year year NN cord-005453-4057qib7 4028 5 the the DT cord-005453-4057qib7 4028 6 group group NN cord-005453-4057qib7 4028 7 met meet VBD cord-005453-4057qib7 4028 8 every every DT cord-005453-4057qib7 4028 9 14 14 CD cord-005453-4057qib7 4028 10 days day NNS cord-005453-4057qib7 4028 11 followed follow VBN cord-005453-4057qib7 4028 12 by by IN cord-005453-4057qib7 4028 13 a a DT cord-005453-4057qib7 4028 14 monthly monthly JJ cord-005453-4057qib7 4028 15 schedule schedule NN cord-005453-4057qib7 4028 16 . . . cord-005453-4057qib7 4029 1 From from IN cord-005453-4057qib7 4029 2 the the DT cord-005453-4057qib7 4029 3 fifth fifth NN cord-005453-4057qib7 4029 4 until until IN cord-005453-4057qib7 4029 5 the the DT cord-005453-4057qib7 4029 6 39th 39th JJ cord-005453-4057qib7 4029 7 meeting meeting NN cord-005453-4057qib7 4029 8 the the DT cord-005453-4057qib7 4029 9 attendance attendance NN cord-005453-4057qib7 4029 10 and and CC cord-005453-4057qib7 4029 11 the the DT cord-005453-4057qib7 4029 12 discussed discuss VBN cord-005453-4057qib7 4029 13 topics topic NNS cord-005453-4057qib7 4029 14 were be VBD cord-005453-4057qib7 4029 15 minuted minute VBN cord-005453-4057qib7 4029 16 by by IN cord-005453-4057qib7 4029 17 the the DT cord-005453-4057qib7 4029 18 facilitator facilitator NN cord-005453-4057qib7 4029 19 . . . cord-005453-4057qib7 4030 1 The the DT cord-005453-4057qib7 4030 2 content content NN cord-005453-4057qib7 4030 3 of of IN cord-005453-4057qib7 4030 4 the the DT cord-005453-4057qib7 4030 5 minutes minute NNS cord-005453-4057qib7 4030 6 was be VBD cord-005453-4057qib7 4030 7 analysed analyse VBN cord-005453-4057qib7 4030 8 by by IN cord-005453-4057qib7 4030 9 a a DT cord-005453-4057qib7 4030 10 combination combination NN cord-005453-4057qib7 4030 11 of of IN cord-005453-4057qib7 4030 12 an an DT cord-005453-4057qib7 4030 13 inductive inductive JJ cord-005453-4057qib7 4030 14 and and CC cord-005453-4057qib7 4030 15 a a DT cord-005453-4057qib7 4030 16 deductive deductive JJ cord-005453-4057qib7 4030 17 approach approach NN cord-005453-4057qib7 4030 18 . . . cord-005453-4057qib7 4031 1 All all DT cord-005453-4057qib7 4031 2 participants participant NNS cord-005453-4057qib7 4031 3 provided provide VBD cord-005453-4057qib7 4031 4 their -PRON- PRP$ cord-005453-4057qib7 4031 5 informed informed JJ cord-005453-4057qib7 4031 6 consent consent NN cord-005453-4057qib7 4031 7 for for IN cord-005453-4057qib7 4031 8 the the DT cord-005453-4057qib7 4031 9 study study NN cord-005453-4057qib7 4031 10 . . . cord-005453-4057qib7 4032 1 Results result NNS cord-005453-4057qib7 4032 2 : : : cord-005453-4057qib7 4033 1 Altogether altogether RB cord-005453-4057qib7 4033 2 23 23 CD cord-005453-4057qib7 4033 3 patients patient NNS cord-005453-4057qib7 4033 4 ( ( -LRB- cord-005453-4057qib7 4033 5 female female NN cord-005453-4057qib7 4033 6 : : : cord-005453-4057qib7 4033 7 n=10 n=10 NNP cord-005453-4057qib7 4033 8 ; ; : cord-005453-4057qib7 4033 9 male male JJ cord-005453-4057qib7 4033 10 : : : cord-005453-4057qib7 4033 11 n=13 n=13 NNP cord-005453-4057qib7 4033 12 ) ) -RRB- cord-005453-4057qib7 4033 13 and and CC cord-005453-4057qib7 4033 14 10 10 CD cord-005453-4057qib7 4033 15 spouses spouse NNS cord-005453-4057qib7 4033 16 / / SYM cord-005453-4057qib7 4033 17 life life NN cord-005453-4057qib7 4033 18 partners partner NNS cord-005453-4057qib7 4033 19 ( ( -LRB- cord-005453-4057qib7 4033 20 female female JJ cord-005453-4057qib7 4033 21 : : : cord-005453-4057qib7 4033 22 n=9 n=9 NN cord-005453-4057qib7 4033 23 ; ; : cord-005453-4057qib7 4033 24 male male JJ cord-005453-4057qib7 4033 25 : : : cord-005453-4057qib7 4033 26 n=1 n=1 CD cord-005453-4057qib7 4033 27 ) ) -RRB- cord-005453-4057qib7 4033 28 participated participate VBD cord-005453-4057qib7 4033 29 . . . cord-005453-4057qib7 4034 1 13 13 CD cord-005453-4057qib7 4034 2 patients patient NNS cord-005453-4057qib7 4034 3 ( ( -LRB- cord-005453-4057qib7 4034 4 57 57 CD cord-005453-4057qib7 4034 5 % % NN cord-005453-4057qib7 4034 6 ) ) -RRB- cord-005453-4057qib7 4034 7 and and CC cord-005453-4057qib7 4034 8 6 6 CD cord-005453-4057qib7 4034 9 spouses spouse NNS cord-005453-4057qib7 4034 10 ( ( -LRB- cord-005453-4057qib7 4034 11 60 60 CD cord-005453-4057qib7 4034 12 % % NN cord-005453-4057qib7 4034 13 ) ) -RRB- cord-005453-4057qib7 4034 14 attended attend VBD cord-005453-4057qib7 4034 15 more more JJR cord-005453-4057qib7 4034 16 than than IN cord-005453-4057qib7 4034 17 one one CD cord-005453-4057qib7 4034 18 meeting meeting NN cord-005453-4057qib7 4034 19 . . . cord-005453-4057qib7 4035 1 Among among IN cord-005453-4057qib7 4035 2 those those DT cord-005453-4057qib7 4035 3 who who WP cord-005453-4057qib7 4035 4 participated participate VBD cord-005453-4057qib7 4035 5 in in IN cord-005453-4057qib7 4035 6 ≥2 ≥2 NNP cord-005453-4057qib7 4035 7 meetings meeting NNS cord-005453-4057qib7 4035 8 the the DT cord-005453-4057qib7 4035 9 median median JJ cord-005453-4057qib7 4035 10 time time NN cord-005453-4057qib7 4035 11 of of IN cord-005453-4057qib7 4035 12 participation participation NN cord-005453-4057qib7 4035 13 was be VBD cord-005453-4057qib7 4035 14 16 16 CD cord-005453-4057qib7 4035 15 months month NNS cord-005453-4057qib7 4035 16 . . . cord-005453-4057qib7 4036 1 The the DT cord-005453-4057qib7 4036 2 median median JJ cord-005453-4057qib7 4036 3 count count NN cord-005453-4057qib7 4036 4 of of IN cord-005453-4057qib7 4036 5 participations participation NNS cord-005453-4057qib7 4036 6 was be VBD cord-005453-4057qib7 4036 7 eight eight CD cord-005453-4057qib7 4036 8 . . . cord-005453-4057qib7 4037 1 30 30 CD cord-005453-4057qib7 4037 2 % % NN cord-005453-4057qib7 4037 3 of of IN cord-005453-4057qib7 4037 4 the the DT cord-005453-4057qib7 4037 5 participants participant NNS cord-005453-4057qib7 4037 6 attended attend VBD cord-005453-4057qib7 4037 7 the the DT cord-005453-4057qib7 4037 8 meetings meeting NNS cord-005453-4057qib7 4037 9 longer long RBR cord-005453-4057qib7 4037 10 than than IN cord-005453-4057qib7 4037 11 one one CD cord-005453-4057qib7 4037 12 year year NN cord-005453-4057qib7 4037 13 , , , cord-005453-4057qib7 4037 14 9 9 CD cord-005453-4057qib7 4037 15 % % NN cord-005453-4057qib7 4037 16 longer long JJR cord-005453-4057qib7 4037 17 than than IN cord-005453-4057qib7 4037 18 three three CD cord-005453-4057qib7 4037 19 years year NNS cord-005453-4057qib7 4037 20 . . . cord-005453-4057qib7 4038 1 There there EX cord-005453-4057qib7 4038 2 was be VBD cord-005453-4057qib7 4038 3 no no DT cord-005453-4057qib7 4038 4 sex sex NN cord-005453-4057qib7 4038 5 difference difference NN cord-005453-4057qib7 4038 6 with with IN cord-005453-4057qib7 4038 7 respect respect NN cord-005453-4057qib7 4038 8 to to IN cord-005453-4057qib7 4038 9 the the DT cord-005453-4057qib7 4038 10 frequency frequency NN cord-005453-4057qib7 4038 11 and and CC cord-005453-4057qib7 4038 12 the the DT cord-005453-4057qib7 4038 13 duration duration NN cord-005453-4057qib7 4038 14 of of IN cord-005453-4057qib7 4038 15 participation participation NN cord-005453-4057qib7 4038 16 . . . cord-005453-4057qib7 4039 1 However however RB cord-005453-4057qib7 4039 2 , , , cord-005453-4057qib7 4039 3 the the DT cord-005453-4057qib7 4039 4 frequency frequency NN cord-005453-4057qib7 4039 5 of of IN cord-005453-4057qib7 4039 6 participation participation NN cord-005453-4057qib7 4039 7 decreased decrease VBD cord-005453-4057qib7 4039 8 significantly significantly RB cord-005453-4057qib7 4039 9 the the DT cord-005453-4057qib7 4039 10 longer long RBR cord-005453-4057qib7 4039 11 a a DT cord-005453-4057qib7 4039 12 participant participant NN cord-005453-4057qib7 4039 13 was be VBD cord-005453-4057qib7 4039 14 attending attend VBG cord-005453-4057qib7 4039 15 the the DT cord-005453-4057qib7 4039 16 meetings meeting NNS cord-005453-4057qib7 4039 17 . . . cord-005453-4057qib7 4040 1 During during IN cord-005453-4057qib7 4040 2 35 35 CD cord-005453-4057qib7 4040 3 group group NN cord-005453-4057qib7 4040 4 meetings meeting NNS cord-005453-4057qib7 4040 5 the the DT cord-005453-4057qib7 4040 6 facilitator facilitator NN cord-005453-4057qib7 4040 7 recorded record VBD cord-005453-4057qib7 4040 8 5138 5138 CD cord-005453-4057qib7 4040 9 thematically thematically RB cord-005453-4057qib7 4040 10 different different JJ cord-005453-4057qib7 4040 11 contributions contribution NNS cord-005453-4057qib7 4040 12 to to IN cord-005453-4057qib7 4040 13 the the DT cord-005453-4057qib7 4040 14 discussions discussion NNS cord-005453-4057qib7 4040 15 divided divide VBN cord-005453-4057qib7 4040 16 in in IN cord-005453-4057qib7 4040 17 37 37 CD cord-005453-4057qib7 4040 18 distinct distinct JJ cord-005453-4057qib7 4040 19 topics topic NNS cord-005453-4057qib7 4040 20 . . . cord-005453-4057qib7 4041 1 These these DT cord-005453-4057qib7 4041 2 topics topic NNS cord-005453-4057qib7 4041 3 were be VBD cord-005453-4057qib7 4041 4 grouped group VBN cord-005453-4057qib7 4041 5 into into IN cord-005453-4057qib7 4041 6 5 5 CD cord-005453-4057qib7 4041 7 main main JJ cord-005453-4057qib7 4041 8 categories category NNS cord-005453-4057qib7 4041 9 [ [ -LRB- cord-005453-4057qib7 4041 10 ( ( -LRB- cord-005453-4057qib7 4041 11 a a DT cord-005453-4057qib7 4041 12 ) ) -RRB- cord-005453-4057qib7 4041 13 medical medical JJ cord-005453-4057qib7 4041 14 topics topic NNS cord-005453-4057qib7 4041 15 , , , cord-005453-4057qib7 4041 16 ( ( -LRB- cord-005453-4057qib7 4041 17 b b LS cord-005453-4057qib7 4041 18 ) ) -RRB- cord-005453-4057qib7 4041 19 private private JJ cord-005453-4057qib7 4041 20 life life NN cord-005453-4057qib7 4041 21 and and CC cord-005453-4057qib7 4041 22 environment environment NN cord-005453-4057qib7 4041 23 , , , cord-005453-4057qib7 4041 24 ( ( -LRB- cord-005453-4057qib7 4041 25 c c NN cord-005453-4057qib7 4041 26 ) ) -RRB- cord-005453-4057qib7 4041 27 human human JJ cord-005453-4057qib7 4041 28 relationships relationship NNS cord-005453-4057qib7 4041 29 , , , cord-005453-4057qib7 4041 30 ( ( -LRB- cord-005453-4057qib7 4041 31 d d LS cord-005453-4057qib7 4041 32 ) ) -RRB- cord-005453-4057qib7 4041 33 physical physical JJ cord-005453-4057qib7 4041 34 and and CC cord-005453-4057qib7 4041 35 mental mental JJ cord-005453-4057qib7 4041 36 condition condition NN cord-005453-4057qib7 4041 37 and and CC cord-005453-4057qib7 4041 38 ( ( -LRB- cord-005453-4057qib7 4041 39 e e LS cord-005453-4057qib7 4041 40 ) ) -RRB- cord-005453-4057qib7 4041 41 the the DT cord-005453-4057qib7 4041 42 support support NN cord-005453-4057qib7 4041 43 group group NN cord-005453-4057qib7 4041 44 itself -PRON- PRP cord-005453-4057qib7 4041 45 ] ] -RRB- cord-005453-4057qib7 4041 46 and and CC cord-005453-4057qib7 4041 47 eight eight CD cord-005453-4057qib7 4041 48 further further JJ cord-005453-4057qib7 4041 49 categories category NNS cord-005453-4057qib7 4041 50 [ [ -LRB- cord-005453-4057qib7 4041 51 ( ( -LRB- cord-005453-4057qib7 4041 52 1 1 CD cord-005453-4057qib7 4041 53 ) ) -RRB- cord-005453-4057qib7 4041 54 compliance compliance NN cord-005453-4057qib7 4041 55 , , , cord-005453-4057qib7 4041 56 ( ( -LRB- cord-005453-4057qib7 4041 57 2 2 LS cord-005453-4057qib7 4041 58 ) ) -RRB- cord-005453-4057qib7 4041 59 economic economic JJ cord-005453-4057qib7 4041 60 issues issue NNS cord-005453-4057qib7 4041 61 , , , cord-005453-4057qib7 4041 62 ( ( -LRB- cord-005453-4057qib7 4041 63 3 3 LS cord-005453-4057qib7 4041 64 ) ) -RRB- cord-005453-4057qib7 4041 65 religion religion NN cord-005453-4057qib7 4041 66 , , , cord-005453-4057qib7 4041 67 ( ( -LRB- cord-005453-4057qib7 4041 68 4 4 LS cord-005453-4057qib7 4041 69 ) ) -RRB- cord-005453-4057qib7 4041 70 sexuality sexuality NN cord-005453-4057qib7 4041 71 , , , cord-005453-4057qib7 4041 72 ( ( -LRB- cord-005453-4057qib7 4041 73 5 5 LS cord-005453-4057qib7 4041 74 ) ) -RRB- cord-005453-4057qib7 4041 75 death death NN cord-005453-4057qib7 4041 76 and and CC cord-005453-4057qib7 4041 77 dying dying NN cord-005453-4057qib7 4041 78 , , , cord-005453-4057qib7 4041 79 ( ( -LRB- cord-005453-4057qib7 4041 80 6 6 CD cord-005453-4057qib7 4041 81 ) ) -RRB- cord-005453-4057qib7 4041 82 support support NN cord-005453-4057qib7 4041 83 and and CC cord-005453-4057qib7 4041 84 coping coping NN cord-005453-4057qib7 4041 85 , , , cord-005453-4057qib7 4041 86 ( ( -LRB- cord-005453-4057qib7 4041 87 7 7 CD cord-005453-4057qib7 4041 88 ) ) -RRB- cord-005453-4057qib7 4041 89 objectives objective NNS cord-005453-4057qib7 4041 90 and and CC cord-005453-4057qib7 4041 91 needs need NNS cord-005453-4057qib7 4042 1 and and CC cord-005453-4057qib7 4042 2 ( ( -LRB- cord-005453-4057qib7 4042 3 8) 8) MD cord-005453-4057qib7 4042 4 not not RB cord-005453-4057qib7 4042 5 otherwise otherwise RB cord-005453-4057qib7 4042 6 specified specify VBN cord-005453-4057qib7 4042 7 issues issue NNS cord-005453-4057qib7 4042 8 ] ] -RRB- cord-005453-4057qib7 4042 9 which which WDT cord-005453-4057qib7 4042 10 could could MD cord-005453-4057qib7 4042 11 not not RB cord-005453-4057qib7 4042 12 be be VB cord-005453-4057qib7 4042 13 grouped group VBN cord-005453-4057qib7 4042 14 in in IN cord-005453-4057qib7 4042 15 one one CD cord-005453-4057qib7 4042 16 of of IN cord-005453-4057qib7 4042 17 the the DT cord-005453-4057qib7 4042 18 main main JJ cord-005453-4057qib7 4042 19 categories category NNS cord-005453-4057qib7 4042 20 . . . cord-005453-4057qib7 4043 1 The the DT cord-005453-4057qib7 4043 2 most most RBS cord-005453-4057qib7 4043 3 frequent frequent JJ cord-005453-4057qib7 4043 4 issues issue NNS cord-005453-4057qib7 4043 5 were be VBD cord-005453-4057qib7 4043 6 medical medical JJ cord-005453-4057qib7 4043 7 topics topic NNS cord-005453-4057qib7 4043 8 ( ( -LRB- cord-005453-4057qib7 4043 9 34 34 CD cord-005453-4057qib7 4043 10 % % NN cord-005453-4057qib7 4043 11 ) ) -RRB- cord-005453-4057qib7 4043 12 , , , cord-005453-4057qib7 4043 13 human human JJ cord-005453-4057qib7 4043 14 relationships relationship NNS cord-005453-4057qib7 4043 15 ( ( -LRB- cord-005453-4057qib7 4043 16 16 16 CD cord-005453-4057qib7 4043 17 % % NN cord-005453-4057qib7 4043 18 ) ) -RRB- cord-005453-4057qib7 4043 19 , , , cord-005453-4057qib7 4043 20 physical physical JJ cord-005453-4057qib7 4043 21 and and CC cord-005453-4057qib7 4043 22 mental mental JJ cord-005453-4057qib7 4043 23 condition condition NN cord-005453-4057qib7 4043 24 ( ( -LRB- cord-005453-4057qib7 4043 25 15 15 CD cord-005453-4057qib7 4043 26 % % NN cord-005453-4057qib7 4043 27 ) ) -RRB- cord-005453-4057qib7 4043 28 , , , cord-005453-4057qib7 4043 29 private private JJ cord-005453-4057qib7 4043 30 life life NN cord-005453-4057qib7 4043 31 and and CC cord-005453-4057qib7 4043 32 environment environment NN cord-005453-4057qib7 4043 33 ( ( -LRB- cord-005453-4057qib7 4043 34 14 14 CD cord-005453-4057qib7 4043 35 % % NN cord-005453-4057qib7 4043 36 ) ) -RRB- cord-005453-4057qib7 4043 37 , , , cord-005453-4057qib7 4043 38 financial financial JJ cord-005453-4057qib7 4043 39 issues issue NNS cord-005453-4057qib7 4043 40 ( ( -LRB- cord-005453-4057qib7 4043 41 5 5 CD cord-005453-4057qib7 4043 42 % % NN cord-005453-4057qib7 4043 43 ) ) -RRB- cord-005453-4057qib7 4043 44 , , , cord-005453-4057qib7 4043 45 the the DT cord-005453-4057qib7 4043 46 support support NN cord-005453-4057qib7 4043 47 group group NN cord-005453-4057qib7 4043 48 itself -PRON- PRP cord-005453-4057qib7 4043 49 ( ( -LRB- cord-005453-4057qib7 4043 50 4 4 CD cord-005453-4057qib7 4043 51 % % NN cord-005453-4057qib7 4043 52 ) ) -RRB- cord-005453-4057qib7 4043 53 , , , cord-005453-4057qib7 4043 54 support support NN cord-005453-4057qib7 4043 55 and and CC cord-005453-4057qib7 4043 56 coping coping NN cord-005453-4057qib7 4043 57 ( ( -LRB- cord-005453-4057qib7 4043 58 4 4 CD cord-005453-4057qib7 4043 59 % % NN cord-005453-4057qib7 4043 60 ) ) -RRB- cord-005453-4057qib7 4043 61 and and CC cord-005453-4057qib7 4043 62 objectives objective NNS cord-005453-4057qib7 4043 63 and and CC cord-005453-4057qib7 4043 64 needs need NNS cord-005453-4057qib7 4043 65 ( ( -LRB- cord-005453-4057qib7 4043 66 4 4 CD cord-005453-4057qib7 4043 67 % % NN cord-005453-4057qib7 4043 68 ) ) -RRB- cord-005453-4057qib7 4043 69 . . . cord-005453-4057qib7 4044 1 Noteworthy noteworthy JJ cord-005453-4057qib7 4044 2 , , , cord-005453-4057qib7 4044 3 death death NN cord-005453-4057qib7 4044 4 and and CC cord-005453-4057qib7 4044 5 dying dying NN cord-005453-4057qib7 4044 6 ( ( -LRB- cord-005453-4057qib7 4044 7 0.5 0.5 CD cord-005453-4057qib7 4044 8 % % NN cord-005453-4057qib7 4044 9 ) ) -RRB- cord-005453-4057qib7 4044 10 were be VBD cord-005453-4057qib7 4044 11 rare rare JJ cord-005453-4057qib7 4044 12 topics topic NNS cord-005453-4057qib7 4044 13 and and CC cord-005453-4057qib7 4044 14 sexuality sexuality NN cord-005453-4057qib7 4044 15 was be VBD cord-005453-4057qib7 4044 16 never never RB cord-005453-4057qib7 4044 17 mentioned mention VBN cord-005453-4057qib7 4044 18 . . . cord-005453-4057qib7 4045 1 Conclusions conclusion NNS cord-005453-4057qib7 4045 2 : : : cord-005453-4057qib7 4046 1 To to IN cord-005453-4057qib7 4046 2 our -PRON- PRP$ cord-005453-4057qib7 4046 3 knowledge knowledge NN cord-005453-4057qib7 4046 4 , , , cord-005453-4057qib7 4046 5 this this DT cord-005453-4057qib7 4046 6 is be VBZ cord-005453-4057qib7 4046 7 the the DT cord-005453-4057qib7 4046 8 first first JJ cord-005453-4057qib7 4046 9 prospective prospective JJ cord-005453-4057qib7 4046 10 and and CC cord-005453-4057qib7 4046 11 systematic systematic JJ cord-005453-4057qib7 4046 12 analysis analysis NN cord-005453-4057qib7 4046 13 of of IN cord-005453-4057qib7 4046 14 a a DT cord-005453-4057qib7 4046 15 professionallyfacilitated professionallyfacilitated JJ cord-005453-4057qib7 4046 16 support support NN cord-005453-4057qib7 4046 17 group group NN cord-005453-4057qib7 4046 18 for for IN cord-005453-4057qib7 4046 19 HCT hct NN cord-005453-4057qib7 4046 20 - - HYPH cord-005453-4057qib7 4046 21 survivors survivor NNS cord-005453-4057qib7 4046 22 . . . cord-005453-4057qib7 4047 1 These these DT cord-005453-4057qib7 4047 2 data datum NNS cord-005453-4057qib7 4047 3 might may MD cord-005453-4057qib7 4047 4 help help VB cord-005453-4057qib7 4047 5 to to TO cord-005453-4057qib7 4047 6 establish establish VB cord-005453-4057qib7 4047 7 support support NN cord-005453-4057qib7 4047 8 groups group NNS cord-005453-4057qib7 4047 9 and and CC cord-005453-4057qib7 4047 10 to to TO cord-005453-4057qib7 4047 11 identify identify VB cord-005453-4057qib7 4047 12 psychosocial psychosocial JJ cord-005453-4057qib7 4047 13 needs need NNS cord-005453-4057qib7 4047 14 of of IN cord-005453-4057qib7 4047 15 patients patient NNS cord-005453-4057qib7 4047 16 and and CC cord-005453-4057qib7 4047 17 targets target NNS cord-005453-4057qib7 4047 18 for for IN cord-005453-4057qib7 4047 19 specific specific JJ cord-005453-4057qib7 4047 20 support support NN cord-005453-4057qib7 4047 21 . . . cord-005453-4057qib7 4048 1 Disclosure disclosure NN cord-005453-4057qib7 4048 2 : : : cord-005453-4057qib7 4048 3 Nothing nothing NN cord-005453-4057qib7 4048 4 to to TO cord-005453-4057qib7 4048 5 declare declare VB cord-005453-4057qib7 4048 6 Background background NN cord-005453-4057qib7 4048 7 : : : cord-005453-4057qib7 4048 8 Endothelial endothelial JJ cord-005453-4057qib7 4048 9 damage damage NN cord-005453-4057qib7 4048 10 is be VBZ cord-005453-4057qib7 4048 11 associated associate VBN cord-005453-4057qib7 4048 12 with with IN cord-005453-4057qib7 4048 13 inflammatory inflammatory JJ cord-005453-4057qib7 4048 14 complications complication NNS cord-005453-4057qib7 4048 15 that that WDT cord-005453-4057qib7 4048 16 appear appear VBP cord-005453-4057qib7 4048 17 early early RB cord-005453-4057qib7 4048 18 after after IN cord-005453-4057qib7 4048 19 HSCT HSCT NNP cord-005453-4057qib7 4048 20 , , , cord-005453-4057qib7 4048 21 such such JJ cord-005453-4057qib7 4048 22 as as IN cord-005453-4057qib7 4048 23 sinusoidal sinusoidal JJ cord-005453-4057qib7 4048 24 obstruction obstruction NN cord-005453-4057qib7 4048 25 syndrome syndrome NN cord-005453-4057qib7 4048 26 or or CC cord-005453-4057qib7 4048 27 acute acute JJ cord-005453-4057qib7 4048 28 GVHD GVHD NNP cord-005453-4057qib7 4048 29 . . . cord-005453-4057qib7 4049 1 Engraftment Engraftment NNP cord-005453-4057qib7 4049 2 syndrome syndrome NN cord-005453-4057qib7 4049 3 ( ( -LRB- cord-005453-4057qib7 4049 4 ES ES NNP cord-005453-4057qib7 4049 5 ) ) -RRB- cord-005453-4057qib7 4049 6 is be VBZ cord-005453-4057qib7 4049 7 an an DT cord-005453-4057qib7 4049 8 inflammatory inflammatory JJ cord-005453-4057qib7 4049 9 condition condition NN cord-005453-4057qib7 4049 10 diagnosed diagnose VBN cord-005453-4057qib7 4049 11 by by IN cord-005453-4057qib7 4049 12 Maiolino Maiolino NNP cord-005453-4057qib7 4049 13 clinical clinical JJ cord-005453-4057qib7 4049 14 score score NN cord-005453-4057qib7 4049 15 . . . cord-005453-4057qib7 4050 1 Potentially potentially RB cord-005453-4057qib7 4050 2 , , , cord-005453-4057qib7 4050 3 ES ES NNP cord-005453-4057qib7 4050 4 can can MD cord-005453-4057qib7 4050 5 exhibit exhibit VB cord-005453-4057qib7 4050 6 high high JJ cord-005453-4057qib7 4050 7 morbidity morbidity NN cord-005453-4057qib7 4050 8 and and CC cord-005453-4057qib7 4050 9 mortality mortality NN cord-005453-4057qib7 4050 10 , , , cord-005453-4057qib7 4050 11 especially especially RB cord-005453-4057qib7 4050 12 after after IN cord-005453-4057qib7 4050 13 autologous autologous JJ cord-005453-4057qib7 4050 14 - - HYPH cord-005453-4057qib7 4050 15 HSCT HSCT NNP cord-005453-4057qib7 4050 16 in in IN cord-005453-4057qib7 4050 17 multiple multiple JJ cord-005453-4057qib7 4050 18 myeloma myeloma NN cord-005453-4057qib7 4050 19 ( ( -LRB- cord-005453-4057qib7 4050 20 MM MM NNP cord-005453-4057qib7 4050 21 ) ) -RRB- cord-005453-4057qib7 4050 22 patients patient NNS cord-005453-4057qib7 4050 23 since since IN cord-005453-4057qib7 4050 24 the the DT cord-005453-4057qib7 4050 25 introduction introduction NN cord-005453-4057qib7 4050 26 of of IN cord-005453-4057qib7 4050 27 new new JJ cord-005453-4057qib7 4050 28 drugs drug NNS cord-005453-4057qib7 4050 29 such such JJ cord-005453-4057qib7 4050 30 proteasome proteasome VBN cord-005453-4057qib7 4050 31 inhibitors inhibitor NNS cord-005453-4057qib7 4050 32 and and CC cord-005453-4057qib7 4050 33 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 4050 34 drugs drug NNS cord-005453-4057qib7 4050 35 ( ( -LRB- cord-005453-4057qib7 4050 36 IMiDs IMiDs NNP cord-005453-4057qib7 4050 37 ) ) -RRB- cord-005453-4057qib7 4050 38 . . . cord-005453-4057qib7 4051 1 The the DT cord-005453-4057qib7 4051 2 objective objective NN cord-005453-4057qib7 4051 3 of of IN cord-005453-4057qib7 4051 4 the the DT cord-005453-4057qib7 4051 5 present present JJ cord-005453-4057qib7 4051 6 study study NN cord-005453-4057qib7 4051 7 was be VBD cord-005453-4057qib7 4051 8 to to TO cord-005453-4057qib7 4051 9 evaluate evaluate VB cord-005453-4057qib7 4051 10 if if IN cord-005453-4057qib7 4051 11 ES ES NNP cord-005453-4057qib7 4051 12 is be VBZ cord-005453-4057qib7 4051 13 associated associate VBN cord-005453-4057qib7 4051 14 with with IN cord-005453-4057qib7 4051 15 endothelial endothelial JJ cord-005453-4057qib7 4051 16 dysfunction dysfunction NN cord-005453-4057qib7 4051 17 in in IN cord-005453-4057qib7 4051 18 patients patient NNS cord-005453-4057qib7 4051 19 with with IN cord-005453-4057qib7 4051 20 MM MM NNP cord-005453-4057qib7 4051 21 who who WP cord-005453-4057qib7 4051 22 underwent undergo VBD cord-005453-4057qib7 4051 23 auto auto NN cord-005453-4057qib7 4051 24 - - HYPH cord-005453-4057qib7 4051 25 HSCT HSCT NNP cord-005453-4057qib7 4051 26 . . . cord-005453-4057qib7 4052 1 Methods method NNS cord-005453-4057qib7 4053 1 : : : cord-005453-4057qib7 4053 2 We -PRON- PRP cord-005453-4057qib7 4053 3 included include VBD cord-005453-4057qib7 4053 4 six six CD cord-005453-4057qib7 4053 5 patients patient NNS cord-005453-4057qib7 4053 6 with with IN cord-005453-4057qib7 4053 7 MM MM NNP cord-005453-4057qib7 4053 8 who who WP cord-005453-4057qib7 4053 9 received receive VBD cord-005453-4057qib7 4053 10 induction induction NN cord-005453-4057qib7 4053 11 treatment treatment NN cord-005453-4057qib7 4053 12 including include VBG cord-005453-4057qib7 4053 13 new new JJ cord-005453-4057qib7 4053 14 drugs drug NNS cord-005453-4057qib7 4053 15 and and CC cord-005453-4057qib7 4053 16 consolidated consolidate VBD cord-005453-4057qib7 4053 17 their -PRON- PRP$ cord-005453-4057qib7 4053 18 response response NN cord-005453-4057qib7 4053 19 with with IN cord-005453-4057qib7 4053 20 an an DT cord-005453-4057qib7 4053 21 autologous autologous JJ cord-005453-4057qib7 4053 22 - - HYPH cord-005453-4057qib7 4053 23 HSCT HSCT NNP cord-005453-4057qib7 4053 24 . . . cord-005453-4057qib7 4054 1 We -PRON- PRP cord-005453-4057qib7 4054 2 analysed analyse VBD cord-005453-4057qib7 4054 3 comparatively comparatively RB cord-005453-4057qib7 4054 4 the the DT cord-005453-4057qib7 4054 5 effect effect NN cord-005453-4057qib7 4054 6 of of IN cord-005453-4057qib7 4054 7 incubating incubate VBG cord-005453-4057qib7 4054 8 endothelial endothelial JJ cord-005453-4057qib7 4054 9 cells cell NNS cord-005453-4057qib7 4054 10 in in IN cord-005453-4057qib7 4054 11 vitro vitro FW cord-005453-4057qib7 4054 12 with with IN cord-005453-4057qib7 4054 13 serum serum NN cord-005453-4057qib7 4054 14 samples sample NNS cord-005453-4057qib7 4054 15 from from IN cord-005453-4057qib7 4054 16 patients patient NNS cord-005453-4057qib7 4054 17 with with IN cord-005453-4057qib7 4054 18 ES ES NNP cord-005453-4057qib7 4054 19 vs. vs. FW cord-005453-4057qib7 4054 20 no no DT cord-005453-4057qib7 4054 21 ES es NN cord-005453-4057qib7 4054 22 . . . cord-005453-4057qib7 4055 1 Serum serum NN cord-005453-4057qib7 4055 2 samples sample NNS cord-005453-4057qib7 4055 3 were be VBD cord-005453-4057qib7 4055 4 collected collect VBN cord-005453-4057qib7 4055 5 before before RB cord-005453-4057qib7 4055 6 ( ( -LRB- cord-005453-4057qib7 4055 7 PRE PRE NNP cord-005453-4057qib7 4055 8 ) ) -RRB- cord-005453-4057qib7 4055 9 , , , cord-005453-4057qib7 4055 10 and and CC cord-005453-4057qib7 4055 11 after after IN cord-005453-4057qib7 4055 12 5 5 CD cord-005453-4057qib7 4055 13 , , , cord-005453-4057qib7 4055 14 7 7 CD cord-005453-4057qib7 4055 15 , , , cord-005453-4057qib7 4055 16 and and CC cord-005453-4057qib7 4055 17 10 10 CD cord-005453-4057qib7 4055 18 days day NNS cord-005453-4057qib7 4055 19 from from IN cord-005453-4057qib7 4055 20 the the DT cord-005453-4057qib7 4055 21 transplant transplant NN cord-005453-4057qib7 4055 22 . . . cord-005453-4057qib7 4056 1 An an DT cord-005453-4057qib7 4056 2 additional additional JJ cord-005453-4057qib7 4056 3 sample sample NN cord-005453-4057qib7 4056 4 was be VBD cord-005453-4057qib7 4056 5 collected collect VBN cord-005453-4057qib7 4056 6 at at IN cord-005453-4057qib7 4056 7 the the DT cord-005453-4057qib7 4056 8 ES ES NNP cord-005453-4057qib7 4056 9 onset onset NN cord-005453-4057qib7 4056 10 and and CC cord-005453-4057qib7 4056 11 at at IN cord-005453-4057qib7 4056 12 the the DT cord-005453-4057qib7 4056 13 discharge discharge NN cord-005453-4057qib7 4056 14 day day NNP cord-005453-4057qib7 4056 15 ( ( -LRB- cord-005453-4057qib7 4056 16 no no DT cord-005453-4057qib7 4056 17 ES ES NNP cord-005453-4057qib7 4056 18 group group NN cord-005453-4057qib7 4056 19 ) ) -RRB- cord-005453-4057qib7 4056 20 . . . cord-005453-4057qib7 4057 1 Endothelial endothelial JJ cord-005453-4057qib7 4057 2 cells cell NNS cord-005453-4057qib7 4057 3 ( ( -LRB- cord-005453-4057qib7 4057 4 HMEC HMEC NNP cord-005453-4057qib7 4057 5 ) ) -RRB- cord-005453-4057qib7 4057 6 in in IN cord-005453-4057qib7 4057 7 culture culture NN cord-005453-4057qib7 4057 8 were be VBD cord-005453-4057qib7 4057 9 exposed expose VBN cord-005453-4057qib7 4057 10 to to IN cord-005453-4057qib7 4057 11 media medium NNS cord-005453-4057qib7 4057 12 containing contain VBG cord-005453-4057qib7 4057 13 20 20 CD cord-005453-4057qib7 4057 14 % % NN cord-005453-4057qib7 4057 15 of of IN cord-005453-4057qib7 4057 16 serum serum NN cord-005453-4057qib7 4057 17 from from IN cord-005453-4057qib7 4057 18 each each DT cord-005453-4057qib7 4057 19 patient patient NN cord-005453-4057qib7 4057 20 for for IN cord-005453-4057qib7 4057 21 24h 24h NNS cord-005453-4057qib7 4057 22 . . . cord-005453-4057qib7 4058 1 Cell cell NN cord-005453-4057qib7 4058 2 growth growth NN cord-005453-4057qib7 4058 3 was be VBD cord-005453-4057qib7 4058 4 controlled control VBN cord-005453-4057qib7 4058 5 morphologically morphologically RB cord-005453-4057qib7 4058 6 . . . cord-005453-4057qib7 4059 1 Expression expression NN cord-005453-4057qib7 4059 2 of of IN cord-005453-4057qib7 4059 3 the the DT cord-005453-4057qib7 4059 4 adhesion adhesion NN cord-005453-4057qib7 4059 5 receptor receptor NN cord-005453-4057qib7 4059 6 ICAM-1 icam-1 NN cord-005453-4057qib7 4059 7 on on IN cord-005453-4057qib7 4059 8 the the DT cord-005453-4057qib7 4059 9 cell cell NN cord-005453-4057qib7 4059 10 surface surface NN cord-005453-4057qib7 4059 11 was be VBD cord-005453-4057qib7 4059 12 analysed analyse VBN cord-005453-4057qib7 4059 13 by by IN cord-005453-4057qib7 4059 14 immunofluorescence immunofluorescence NN cord-005453-4057qib7 4059 15 , , , cord-005453-4057qib7 4059 16 and and CC cord-005453-4057qib7 4059 17 activation activation NN cord-005453-4057qib7 4059 18 of of IN cord-005453-4057qib7 4059 19 the the DT cord-005453-4057qib7 4059 20 inflammation inflammation NN cord-005453-4057qib7 4059 21 related relate VBN cord-005453-4057qib7 4059 22 p-38 p-38 NNP cord-005453-4057qib7 4059 23 MAPK MAPK NNP cord-005453-4057qib7 4059 24 signalling signal VBG cord-005453-4057qib7 4059 25 pathway pathway NN cord-005453-4057qib7 4059 26 was be VBD cord-005453-4057qib7 4059 27 evaluated evaluate VBN cord-005453-4057qib7 4059 28 by by IN cord-005453-4057qib7 4059 29 SDS SDS NNP cord-005453-4057qib7 4059 30 - - HYPH cord-005453-4057qib7 4059 31 PAGE PAGE NNP cord-005453-4057qib7 4059 32 and and CC cord-005453-4057qib7 4059 33 western western JJ cord-005453-4057qib7 4059 34 blot blot NN cord-005453-4057qib7 4059 35 . . . cord-005453-4057qib7 4060 1 Results result NNS cord-005453-4057qib7 4060 2 : : : cord-005453-4057qib7 4061 1 Exposure exposure NN cord-005453-4057qib7 4061 2 of of IN cord-005453-4057qib7 4061 3 HMEC HMEC NNP cord-005453-4057qib7 4061 4 monolayers monolayer NNS cord-005453-4057qib7 4061 5 to to IN cord-005453-4057qib7 4061 6 sera sera NNP cord-005453-4057qib7 4061 7 from from IN cord-005453-4057qib7 4061 8 patients patient NNS cord-005453-4057qib7 4061 9 who who WP cord-005453-4057qib7 4061 10 developed develop VBD cord-005453-4057qib7 4061 11 ES ES NNP cord-005453-4057qib7 4062 1 ( ( -LRB- cord-005453-4057qib7 4062 2 onset onset NNP cord-005453-4057qib7 4062 3 day day NN cord-005453-4057qib7 4062 4 , , , cord-005453-4057qib7 4062 5 n=4 n=4 NNS cord-005453-4057qib7 4062 6 ) ) -RRB- cord-005453-4057qib7 4062 7 resulted result VBD cord-005453-4057qib7 4062 8 in in IN cord-005453-4057qib7 4062 9 an an DT cord-005453-4057qib7 4062 10 increased increase VBN cord-005453-4057qib7 4062 11 ICAM-1 icam-1 NN cord-005453-4057qib7 4062 12 expression expression NN cord-005453-4057qib7 4062 13 on on IN cord-005453-4057qib7 4062 14 the the DT cord-005453-4057qib7 4062 15 cell cell NN cord-005453-4057qib7 4062 16 surface surface NN cord-005453-4057qib7 4062 17 , , , cord-005453-4057qib7 4062 18 higher high JJR cord-005453-4057qib7 4062 19 that that IN cord-005453-4057qib7 4062 20 the the DT cord-005453-4057qib7 4062 21 observed observe VBN cord-005453-4057qib7 4062 22 with with IN cord-005453-4057qib7 4062 23 sera sera NNP cord-005453-4057qib7 4062 24 from from IN cord-005453-4057qib7 4062 25 patients patient NNS cord-005453-4057qib7 4062 26 who who WP cord-005453-4057qib7 4062 27 did do VBD cord-005453-4057qib7 4062 28 not not RB cord-005453-4057qib7 4062 29 develop develop VB cord-005453-4057qib7 4062 30 ES ES NNP cord-005453-4057qib7 4062 31 ( ( -LRB- cord-005453-4057qib7 4062 32 discharge discharge NN cord-005453-4057qib7 4062 33 day day NN cord-005453-4057qib7 4062 34 , , , cord-005453-4057qib7 4062 35 n=4 n=4 NNS cord-005453-4057qib7 4062 36 ) ) -RRB- cord-005453-4057qib7 4062 37 ( ( -LRB- cord-005453-4057qib7 4062 38 26.4 26.4 CD cord-005453-4057qib7 4062 39 % % NN cord-005453-4057qib7 4062 40 of of IN cord-005453-4057qib7 4062 41 labelled labelled JJ cord-005453-4057qib7 4062 42 area area NN cord-005453-4057qib7 4062 43 vs. vs. CC cord-005453-4057qib7 4062 44 6.4 6.4 CD cord-005453-4057qib7 4062 45 % % NN cord-005453-4057qib7 4062 46 , , , cord-005453-4057qib7 4062 47 respectively respectively RB cord-005453-4057qib7 4062 48 ) ) -RRB- cord-005453-4057qib7 4062 49 . . . cord-005453-4057qib7 4063 1 In in IN cord-005453-4057qib7 4063 2 addition addition NN cord-005453-4057qib7 4063 3 , , , cord-005453-4057qib7 4063 4 in in IN cord-005453-4057qib7 4063 5 experiments experiment NNS cord-005453-4057qib7 4063 6 with with IN cord-005453-4057qib7 4063 7 sera sera NNP cord-005453-4057qib7 4063 8 from from IN cord-005453-4057qib7 4063 9 patients patient NNS cord-005453-4057qib7 4063 10 not not RB cord-005453-4057qib7 4063 11 developing develop VBG cord-005453-4057qib7 4063 12 ES ES NNP cord-005453-4057qib7 4063 13 , , , cord-005453-4057qib7 4063 14 ICAM-1 icam-1 NN cord-005453-4057qib7 4063 15 expression expression NN cord-005453-4057qib7 4063 16 on on IN cord-005453-4057qib7 4063 17 cells cell NNS cord-005453-4057qib7 4063 18 exposed expose VBN cord-005453-4057qib7 4063 19 to to IN cord-005453-4057qib7 4063 20 sera sera NNP cord-005453-4057qib7 4063 21 from from IN cord-005453-4057qib7 4063 22 day day NN cord-005453-4057qib7 4063 23 +10 +10 CD cord-005453-4057qib7 4063 24 was be VBD cord-005453-4057qib7 4063 25 reduced reduce VBN cord-005453-4057qib7 4063 26 with with IN cord-005453-4057qib7 4063 27 respect respect NN cord-005453-4057qib7 4063 28 to to IN cord-005453-4057qib7 4063 29 the the DT cord-005453-4057qib7 4063 30 observed observe VBN cord-005453-4057qib7 4063 31 with with IN cord-005453-4057qib7 4063 32 sera sera NNP cord-005453-4057qib7 4063 33 from from IN cord-005453-4057qib7 4063 34 day day NN cord-005453-4057qib7 4063 35 +5 +5 XX cord-005453-4057qib7 4063 36 , , , cord-005453-4057qib7 4063 37 probably probably RB cord-005453-4057qib7 4063 38 due due IN cord-005453-4057qib7 4063 39 to to IN cord-005453-4057qib7 4063 40 the the DT cord-005453-4057qib7 4063 41 corticosteroid corticosteroid NN cord-005453-4057qib7 4063 42 used use VBN cord-005453-4057qib7 4063 43 as as IN cord-005453-4057qib7 4063 44 a a DT cord-005453-4057qib7 4063 45 prophylaxis prophylaxis NN cord-005453-4057qib7 4063 46 in in IN cord-005453-4057qib7 4063 47 our -PRON- PRP$ cord-005453-4057qib7 4063 48 centre centre NN cord-005453-4057qib7 4063 49 . . . cord-005453-4057qib7 4064 1 This this DT cord-005453-4057qib7 4064 2 reduction reduction NN cord-005453-4057qib7 4064 3 was be VBD cord-005453-4057qib7 4064 4 not not RB cord-005453-4057qib7 4064 5 observed observe VBN cord-005453-4057qib7 4064 6 in in IN cord-005453-4057qib7 4064 7 ES ES NNP cord-005453-4057qib7 4064 8 patients patient NNS cord-005453-4057qib7 4064 9 . . . cord-005453-4057qib7 4065 1 Regarding regard VBG cord-005453-4057qib7 4065 2 phosphorylation phosphorylation NN cord-005453-4057qib7 4065 3 of of IN cord-005453-4057qib7 4065 4 p-38 p-38 NNP cord-005453-4057qib7 4065 5 , , , cord-005453-4057qib7 4065 6 it -PRON- PRP cord-005453-4057qib7 4065 7 was be VBD cord-005453-4057qib7 4065 8 significantly significantly RB cord-005453-4057qib7 4065 9 higher high JJR cord-005453-4057qib7 4065 10 in in IN cord-005453-4057qib7 4065 11 cells cell NNS cord-005453-4057qib7 4065 12 exposed expose VBN cord-005453-4057qib7 4065 13 to to IN cord-005453-4057qib7 4065 14 sera sera NNP cord-005453-4057qib7 4065 15 from from IN cord-005453-4057qib7 4065 16 ES ES NNP cord-005453-4057qib7 4065 17 patients patient NNS cord-005453-4057qib7 4065 18 than than IN cord-005453-4057qib7 4065 19 in in IN cord-005453-4057qib7 4065 20 response response NN cord-005453-4057qib7 4065 21 to to IN cord-005453-4057qib7 4065 22 sera sera NNP cord-005453-4057qib7 4065 23 from from IN cord-005453-4057qib7 4065 24 patients patient NNS cord-005453-4057qib7 4065 25 who who WP cord-005453-4057qib7 4065 26 did do VBD cord-005453-4057qib7 4065 27 not not RB cord-005453-4057qib7 4065 28 develop develop VB cord-005453-4057qib7 4065 29 ES ES NNP cord-005453-4057qib7 4065 30 . . . cord-005453-4057qib7 4066 1 Conclusions conclusion NNS cord-005453-4057qib7 4066 2 : : : cord-005453-4057qib7 4067 1 The the DT cord-005453-4057qib7 4067 2 increase increase NN cord-005453-4057qib7 4067 3 in in IN cord-005453-4057qib7 4067 4 the the DT cord-005453-4057qib7 4067 5 expression expression NN cord-005453-4057qib7 4067 6 of of IN cord-005453-4057qib7 4067 7 the the DT cord-005453-4057qib7 4067 8 adhesion adhesion NN cord-005453-4057qib7 4067 9 receptor receptor NN cord-005453-4057qib7 4067 10 ICAM-1 icam-1 NN cord-005453-4057qib7 4067 11 on on IN cord-005453-4057qib7 4067 12 the the DT cord-005453-4057qib7 4067 13 surface surface NN cord-005453-4057qib7 4067 14 and and CC cord-005453-4057qib7 4067 15 the the DT cord-005453-4057qib7 4067 16 intracellular intracellular JJ cord-005453-4057qib7 4067 17 activation activation NN cord-005453-4057qib7 4067 18 of of IN cord-005453-4057qib7 4067 19 p38MAPK p38MAPK NNPS cord-005453-4057qib7 4067 20 in in IN cord-005453-4057qib7 4067 21 endothelial endothelial JJ cord-005453-4057qib7 4067 22 cells cell NNS cord-005453-4057qib7 4067 23 exposed expose VBN cord-005453-4057qib7 4067 24 to to IN cord-005453-4057qib7 4067 25 sera sera NNP cord-005453-4057qib7 4067 26 from from IN cord-005453-4057qib7 4067 27 patients patient NNS cord-005453-4057qib7 4067 28 developing develop VBG cord-005453-4057qib7 4067 29 ES ES NNP cord-005453-4057qib7 4067 30 indicates indicate VBZ cord-005453-4057qib7 4067 31 the the DT cord-005453-4057qib7 4067 32 existence existence NN cord-005453-4057qib7 4067 33 of of IN cord-005453-4057qib7 4067 34 endothelial endothelial JJ cord-005453-4057qib7 4067 35 activation activation NN cord-005453-4057qib7 4067 36 in in IN cord-005453-4057qib7 4067 37 association association NN cord-005453-4057qib7 4067 38 with with IN cord-005453-4057qib7 4067 39 ES ES NNP cord-005453-4057qib7 4067 40 . . . cord-005453-4057qib7 4068 1 Interestingly interestingly RB cord-005453-4057qib7 4068 2 , , , cord-005453-4057qib7 4068 3 the the DT cord-005453-4057qib7 4068 4 prophylaxis prophylaxis NN cord-005453-4057qib7 4068 5 of of IN cord-005453-4057qib7 4068 6 ES ES NNP cord-005453-4057qib7 4068 7 with with IN cord-005453-4057qib7 4068 8 corticosteroid corticosteroid NN cord-005453-4057qib7 4068 9 seems seem VBZ cord-005453-4057qib7 4068 10 to to TO cord-005453-4057qib7 4068 11 be be VB cord-005453-4057qib7 4068 12 less less RBR cord-005453-4057qib7 4068 13 effective effective JJ cord-005453-4057qib7 4068 14 in in IN cord-005453-4057qib7 4068 15 patients patient NNS cord-005453-4057qib7 4068 16 who who WP cord-005453-4057qib7 4068 17 developed develop VBD cord-005453-4057qib7 4068 18 ES ES NNP cord-005453-4057qib7 4068 19 than than IN cord-005453-4057qib7 4068 20 in in IN cord-005453-4057qib7 4068 21 patients patient NNS cord-005453-4057qib7 4068 22 who who WP cord-005453-4057qib7 4068 23 did do VBD cord-005453-4057qib7 4068 24 not not RB cord-005453-4057qib7 4068 25 develop develop VB cord-005453-4057qib7 4068 26 this this DT cord-005453-4057qib7 4068 27 complication complication NN cord-005453-4057qib7 4068 28 . . . cord-005453-4057qib7 4069 1 These these DT cord-005453-4057qib7 4069 2 results result NNS cord-005453-4057qib7 4069 3 need need VBP cord-005453-4057qib7 4069 4 to to TO cord-005453-4057qib7 4069 5 be be VB cord-005453-4057qib7 4069 6 validated validate VBN cord-005453-4057qib7 4069 7 in in IN cord-005453-4057qib7 4069 8 a a DT cord-005453-4057qib7 4069 9 higher high JJR cord-005453-4057qib7 4069 10 number number NN cord-005453-4057qib7 4069 11 of of IN cord-005453-4057qib7 4069 12 patients patient NNS cord-005453-4057qib7 4069 13 and and CC cord-005453-4057qib7 4069 14 modifications modification NNS cord-005453-4057qib7 4069 15 in in IN cord-005453-4057qib7 4069 16 additional additional JJ cord-005453-4057qib7 4069 17 markers marker NNS cord-005453-4057qib7 4069 18 of of IN cord-005453-4057qib7 4069 19 endothelial endothelial JJ cord-005453-4057qib7 4069 20 dysfunction dysfunction NN cord-005453-4057qib7 4069 21 should should MD cord-005453-4057qib7 4069 22 be be VB cord-005453-4057qib7 4069 23 investigated investigate VBN cord-005453-4057qib7 4069 24 . . . cord-005453-4057qib7 4070 1 Disclosure disclosure NN cord-005453-4057qib7 4070 2 : : : cord-005453-4057qib7 4070 3 Gonzalo Gonzalo NNP cord-005453-4057qib7 4070 4 Gutiérrez Gutiérrez NNP cord-005453-4057qib7 4070 5 - - HYPH cord-005453-4057qib7 4070 6 García García NNP cord-005453-4057qib7 4071 1 : : : cord-005453-4057qib7 4071 2 Honoraria Honoraria NNP cord-005453-4057qib7 4071 3 from from IN cord-005453-4057qib7 4071 4 Gilead Gilead NNP cord-005453-4057qib7 4071 5 . . . cord-005453-4057qib7 4072 1 Grant grant VB cord-005453-4057qib7 4072 2 from from IN cord-005453-4057qib7 4072 3 Jazz jazz NN cord-005453-4057qib7 4072 4 Pharmaceutical Pharmaceutical NNP cord-005453-4057qib7 4073 1 The the DT cord-005453-4057qib7 4073 2 other other JJ cord-005453-4057qib7 4073 3 authors author NNS cord-005453-4057qib7 4073 4 do do VBP cord-005453-4057qib7 4073 5 not not RB cord-005453-4057qib7 4073 6 have have VB cord-005453-4057qib7 4073 7 any any DT cord-005453-4057qib7 4073 8 disclosure disclosure NN cord-005453-4057qib7 4073 9 to to TO cord-005453-4057qib7 4073 10 comment comment VB cord-005453-4057qib7 4073 11 . . . cord-005453-4057qib7 4074 1 P192 P192 NNP cord-005453-4057qib7 4074 2 association association NN cord-005453-4057qib7 4074 3 between between IN cord-005453-4057qib7 4074 4 uric uric JJ cord-005453-4057qib7 4074 5 acid acid NN cord-005453-4057qib7 4074 6 levels level NNS cord-005453-4057qib7 4074 7 before before IN cord-005453-4057qib7 4074 8 and and CC cord-005453-4057qib7 4074 9 after after IN cord-005453-4057qib7 4074 10 allogeneic allogeneic NN cord-005453-4057qib7 4074 11 haematopoetic haematopoetic JJ cord-005453-4057qib7 4074 12 stem stem NN cord-005453-4057qib7 4074 13 cell cell NN cord-005453-4057qib7 4074 14 transplant transplant NN cord-005453-4057qib7 4074 15 and and CC cord-005453-4057qib7 4074 16 transplant transplant NN cord-005453-4057qib7 4074 17 outcomes outcome NNS cord-005453-4057qib7 4074 18 : : : cord-005453-4057qib7 4075 1 A a DT cord-005453-4057qib7 4075 2 single single JJ cord-005453-4057qib7 4075 3 centre centre NN cord-005453-4057qib7 4075 4 experience experience NN cord-005453-4057qib7 4076 1 Background background NN cord-005453-4057qib7 4076 2 : : : cord-005453-4057qib7 4076 3 Uric uric NN cord-005453-4057qib7 4076 4 acid acid NN cord-005453-4057qib7 4076 5 ( ( -LRB- cord-005453-4057qib7 4076 6 UA UA NNP cord-005453-4057qib7 4076 7 ) ) -RRB- cord-005453-4057qib7 4076 8 is be VBZ cord-005453-4057qib7 4076 9 a a DT cord-005453-4057qib7 4076 10 known know VBN cord-005453-4057qib7 4076 11 endogenous endogenous JJ cord-005453-4057qib7 4076 12 danger danger NN cord-005453-4057qib7 4076 13 signal signal NN cord-005453-4057qib7 4076 14 which which WDT cord-005453-4057qib7 4076 15 activates activate VBZ cord-005453-4057qib7 4076 16 the the DT cord-005453-4057qib7 4076 17 NOD nod JJ cord-005453-4057qib7 4076 18 - - HYPH cord-005453-4057qib7 4076 19 like like JJ cord-005453-4057qib7 4076 20 receptor receptor NN cord-005453-4057qib7 4076 21 protein protein NN cord-005453-4057qib7 4076 22 ( ( -LRB- cord-005453-4057qib7 4076 23 NLRP)3 NLRP)3 NNP cord-005453-4057qib7 4076 24 inflasome inflasome NNP cord-005453-4057qib7 4076 25 . . . cord-005453-4057qib7 4077 1 UA UA NNP cord-005453-4057qib7 4077 2 is be VBZ cord-005453-4057qib7 4077 3 released release VBN cord-005453-4057qib7 4077 4 from from IN cord-005453-4057qib7 4077 5 injured injured JJ cord-005453-4057qib7 4077 6 cells cell NNS cord-005453-4057qib7 4077 7 during during IN cord-005453-4057qib7 4077 8 conditioning conditioning NN cord-005453-4057qib7 4077 9 in in IN cord-005453-4057qib7 4077 10 allogeneic allogeneic NN cord-005453-4057qib7 4077 11 stem stem NN cord-005453-4057qib7 4077 12 cell cell NN cord-005453-4057qib7 4077 13 transplantation transplantation NN cord-005453-4057qib7 4077 14 ( ( -LRB- cord-005453-4057qib7 4077 15 HSCT HSCT NNP cord-005453-4057qib7 4077 16 ) ) -RRB- cord-005453-4057qib7 4077 17 . . . cord-005453-4057qib7 4078 1 A a DT cord-005453-4057qib7 4078 2 pre pre JJ cord-005453-4057qib7 4078 3 - - JJ cord-005453-4057qib7 4078 4 clinical clinical JJ cord-005453-4057qib7 4078 5 study study NN cord-005453-4057qib7 4078 6 has have VBZ cord-005453-4057qib7 4078 7 demonstrated demonstrate VBN cord-005453-4057qib7 4078 8 that that IN cord-005453-4057qib7 4078 9 NLRP3 NLRP3 NNP cord-005453-4057qib7 4078 10 inflasome inflasome NN cord-005453-4057qib7 4078 11 - - HYPH cord-005453-4057qib7 4078 12 mediated mediate VBN cord-005453-4057qib7 4078 13 IL-1 IL-1 NNP cord-005453-4057qib7 4078 14 production production NN cord-005453-4057qib7 4078 15 regulates regulate VBZ cord-005453-4057qib7 4078 16 graft graft NN cord-005453-4057qib7 4078 17 - - HYPH cord-005453-4057qib7 4078 18 versushost versushost NN cord-005453-4057qib7 4078 19 disease disease NN cord-005453-4057qib7 4078 20 ( ( -LRB- cord-005453-4057qib7 4078 21 GVHD GVHD NNP cord-005453-4057qib7 4078 22 ) ) -RRB- cord-005453-4057qib7 4078 23 . . . cord-005453-4057qib7 4079 1 The the DT cord-005453-4057qib7 4079 2 UA UA NNP cord-005453-4057qib7 4079 3 role role NN cord-005453-4057qib7 4079 4 in in IN cord-005453-4057qib7 4079 5 inflammation inflammation NN cord-005453-4057qib7 4079 6 and and CC cord-005453-4057qib7 4079 7 GVHD GVHD NNP cord-005453-4057qib7 4079 8 is be VBZ cord-005453-4057qib7 4079 9 unclear unclear JJ cord-005453-4057qib7 4079 10 . . . cord-005453-4057qib7 4080 1 There there EX cord-005453-4057qib7 4080 2 are be VBP cord-005453-4057qib7 4080 3 discordant discordant JJ cord-005453-4057qib7 4080 4 reports report NNS cord-005453-4057qib7 4080 5 in in IN cord-005453-4057qib7 4080 6 the the DT cord-005453-4057qib7 4080 7 literature literature NN cord-005453-4057qib7 4080 8 about about IN cord-005453-4057qib7 4080 9 a a DT cord-005453-4057qib7 4080 10 potential potential JJ cord-005453-4057qib7 4080 11 protective protective JJ cord-005453-4057qib7 4080 12 role role NN cord-005453-4057qib7 4080 13 of of IN cord-005453-4057qib7 4080 14 UA UA NNP cord-005453-4057qib7 4080 15 on on IN cord-005453-4057qib7 4080 16 GVHD GVHD NNP cord-005453-4057qib7 4080 17 after after IN cord-005453-4057qib7 4080 18 a a DT cord-005453-4057qib7 4080 19 HSCT HSCT NNP cord-005453-4057qib7 4080 20 . . . cord-005453-4057qib7 4081 1 Methods method NNS cord-005453-4057qib7 4081 2 : : : cord-005453-4057qib7 4081 3 We -PRON- PRP cord-005453-4057qib7 4081 4 performed perform VBD cord-005453-4057qib7 4081 5 a a DT cord-005453-4057qib7 4081 6 retrospective retrospective JJ cord-005453-4057qib7 4081 7 study study NN cord-005453-4057qib7 4081 8 to to TO cord-005453-4057qib7 4081 9 assess assess VB cord-005453-4057qib7 4081 10 the the DT cord-005453-4057qib7 4081 11 association association NN cord-005453-4057qib7 4081 12 between between IN cord-005453-4057qib7 4081 13 serum serum NN cord-005453-4057qib7 4081 14 UA UA NNP cord-005453-4057qib7 4081 15 levels level NNS cord-005453-4057qib7 4081 16 pre pre VBP cord-005453-4057qib7 4081 17 - - JJ cord-005453-4057qib7 4081 18 and and CC cord-005453-4057qib7 4081 19 post- post- NN cord-005453-4057qib7 4081 20 Table table NN cord-005453-4057qib7 4081 21 ] ] -RRB- cord-005453-4057qib7 4081 22 1 1 CD cord-005453-4057qib7 4081 23 . . . cord-005453-4057qib7 4082 1 Table table NN cord-005453-4057qib7 4082 2 1 1 CD cord-005453-4057qib7 4082 3 ] ] -RRB- cord-005453-4057qib7 4082 4 Results result NNS cord-005453-4057qib7 4082 5 : : : cord-005453-4057qib7 4083 1 The the DT cord-005453-4057qib7 4083 2 characteristics characteristic NNS cord-005453-4057qib7 4083 3 of of IN cord-005453-4057qib7 4083 4 the the DT cord-005453-4057qib7 4083 5 142 142 CD cord-005453-4057qib7 4083 6 patients patient NNS cord-005453-4057qib7 4083 7 are be VBP cord-005453-4057qib7 4083 8 shown show VBN cord-005453-4057qib7 4083 9 in in IN cord-005453-4057qib7 4083 10 Table Table NNP cord-005453-4057qib7 4083 11 1 1 CD cord-005453-4057qib7 4083 12 . . . cord-005453-4057qib7 4084 1 Median median JJ cord-005453-4057qib7 4084 2 age age NN cord-005453-4057qib7 4084 3 was be VBD cord-005453-4057qib7 4084 4 52 52 CD cord-005453-4057qib7 4084 5 years year NNS cord-005453-4057qib7 4085 1 ( ( -LRB- cord-005453-4057qib7 4085 2 range range NNP cord-005453-4057qib7 4085 3 15 15 CD cord-005453-4057qib7 4085 4 - - SYM cord-005453-4057qib7 4085 5 69 69 CD cord-005453-4057qib7 4085 6 ) ) -RRB- cord-005453-4057qib7 4085 7 , , , cord-005453-4057qib7 4085 8 and and CC cord-005453-4057qib7 4085 9 80 80 CD cord-005453-4057qib7 4085 10 patients patient NNS cord-005453-4057qib7 4085 11 ( ( -LRB- cord-005453-4057qib7 4085 12 56 56 CD cord-005453-4057qib7 4085 13 % % NN cord-005453-4057qib7 4085 14 ) ) -RRB- cord-005453-4057qib7 4085 15 were be VBD cord-005453-4057qib7 4085 16 male male JJ cord-005453-4057qib7 4085 17 . . . cord-005453-4057qib7 4086 1 Twenty twenty CD cord-005453-4057qib7 4086 2 - - HYPH cord-005453-4057qib7 4086 3 seven seven CD cord-005453-4057qib7 4086 4 patients patient NNS cord-005453-4057qib7 4086 5 ( ( -LRB- cord-005453-4057qib7 4086 6 19 19 CD cord-005453-4057qib7 4086 7 % % NN cord-005453-4057qib7 4086 8 ) ) -RRB- cord-005453-4057qib7 4086 9 received receive VBD cord-005453-4057qib7 4086 10 low low JJ cord-005453-4057qib7 4086 11 doses dose NNS cord-005453-4057qib7 4086 12 ATG ATG NNP cord-005453-4057qib7 4086 13 as as IN cord-005453-4057qib7 4086 14 part part NN cord-005453-4057qib7 4086 15 of of IN cord-005453-4057qib7 4086 16 GVHD GVHD NNP cord-005453-4057qib7 4086 17 prophylaxis prophylaxis NN cord-005453-4057qib7 4086 18 . . . cord-005453-4057qib7 4087 1 Allopurinol Allopurinol NNP cord-005453-4057qib7 4087 2 was be VBD cord-005453-4057qib7 4087 3 from from IN cord-005453-4057qib7 4087 4 the the DT cord-005453-4057qib7 4087 5 day day NN cord-005453-4057qib7 4087 6 before before IN cord-005453-4057qib7 4087 7 start start NN cord-005453-4057qib7 4087 8 of of IN cord-005453-4057qib7 4087 9 conditioning conditioning NN cord-005453-4057qib7 4087 10 therapy therapy NN cord-005453-4057qib7 4087 11 until until IN cord-005453-4057qib7 4087 12 day day NN cord-005453-4057qib7 4087 13 0 0 CD cord-005453-4057qib7 4087 14 . . . cord-005453-4057qib7 4088 1 The the DT cord-005453-4057qib7 4088 2 median median JJ cord-005453-4057qib7 4088 3 levels level NNS cord-005453-4057qib7 4088 4 of of IN cord-005453-4057qib7 4088 5 UA UA NNP cord-005453-4057qib7 4088 6 were be VBD cord-005453-4057qib7 4088 7 4,8 4,8 CD cord-005453-4057qib7 4088 8 mg/ mg/ NN cord-005453-4057qib7 4088 9 dL dl NN cord-005453-4057qib7 4088 10 before before IN cord-005453-4057qib7 4088 11 conditioning conditioning NN cord-005453-4057qib7 4088 12 , , , cord-005453-4057qib7 4089 1 2,85 2,85 CD cord-005453-4057qib7 4089 2 mg mg NNP cord-005453-4057qib7 4089 3 / / SYM cord-005453-4057qib7 4089 4 dL dl NN cord-005453-4057qib7 4089 5 at at IN cord-005453-4057qib7 4089 6 day day NN cord-005453-4057qib7 4089 7 0 0 CD cord-005453-4057qib7 4090 1 , , , cord-005453-4057qib7 4090 2 3,1 3,1 CD cord-005453-4057qib7 4090 3 mg mg NNP cord-005453-4057qib7 4090 4 / / SYM cord-005453-4057qib7 4090 5 dL dl NN cord-005453-4057qib7 4090 6 at at IN cord-005453-4057qib7 4090 7 day day NN cord-005453-4057qib7 4090 8 +7 +7 CD cord-005453-4057qib7 4090 9 and and CC cord-005453-4057qib7 4090 10 3,2 3,2 CD cord-005453-4057qib7 4090 11 mg mg NNP cord-005453-4057qib7 4090 12 / / SYM cord-005453-4057qib7 4090 13 dL dl NN cord-005453-4057qib7 4090 14 at at IN cord-005453-4057qib7 4090 15 day day NN cord-005453-4057qib7 4090 16 +14 +14 CD cord-005453-4057qib7 4090 17 . . . cord-005453-4057qib7 4091 1 There there EX cord-005453-4057qib7 4091 2 was be VBD cord-005453-4057qib7 4091 3 no no DT cord-005453-4057qib7 4091 4 impact impact NN cord-005453-4057qib7 4091 5 between between IN cord-005453-4057qib7 4091 6 the the DT cord-005453-4057qib7 4091 7 UA UA NNP cord-005453-4057qib7 4091 8 levels level NNS cord-005453-4057qib7 4091 9 and and CC cord-005453-4057qib7 4091 10 OS os NN cord-005453-4057qib7 4091 11 at at IN cord-005453-4057qib7 4091 12 any any DT cord-005453-4057qib7 4091 13 time time NN cord-005453-4057qib7 4091 14 of of IN cord-005453-4057qib7 4091 15 the the DT cord-005453-4057qib7 4091 16 HSCT HSCT NNP cord-005453-4057qib7 4091 17 . . . cord-005453-4057qib7 4092 1 UA UA NNP cord-005453-4057qib7 4092 2 levels level NNS cord-005453-4057qib7 4092 3 at at IN cord-005453-4057qib7 4092 4 day day NN cord-005453-4057qib7 4092 5 +7 +7 '' cord-005453-4057qib7 4092 6 were be VBD cord-005453-4057qib7 4092 7 associated associate VBN cord-005453-4057qib7 4092 8 with with IN cord-005453-4057qib7 4092 9 a a DT cord-005453-4057qib7 4092 10 higher high JJR cord-005453-4057qib7 4092 11 CI CI NNP cord-005453-4057qib7 4092 12 relapse relapse NN cord-005453-4057qib7 4092 13 at at IN cord-005453-4057qib7 4092 14 5 5 CD cord-005453-4057qib7 4092 15 years year NNS cord-005453-4057qib7 4092 16 ( ( -LRB- cord-005453-4057qib7 4092 17 34 34 CD cord-005453-4057qib7 4092 18 % % NN cord-005453-4057qib7 4092 19 [ [ -LRB- cord-005453-4057qib7 4092 20 95 95 CD cord-005453-4057qib7 4092 21 % % NN cord-005453-4057qib7 4092 22 CI CI NNP cord-005453-4057qib7 4092 23 , , , cord-005453-4057qib7 4092 24 20 20 CD cord-005453-4057qib7 4092 25 - - SYM cord-005453-4057qib7 4092 26 49 49 CD cord-005453-4057qib7 4092 27 % % NN cord-005453-4057qib7 4092 28 ] ] -RRB- cord-005453-4057qib7 4092 29 for for IN cord-005453-4057qib7 4092 30 UA UA NNP cord-005453-4057qib7 4092 31 level level NN cord-005453-4057qib7 4092 32 > > XX cord-005453-4057qib7 4093 1 3,1 3,1 NFP cord-005453-4057qib7 4094 1 mg mg NNP cord-005453-4057qib7 4094 2 / / SYM cord-005453-4057qib7 4094 3 dL dL NNP cord-005453-4057qib7 4094 4 , , , cord-005453-4057qib7 4094 5 and and CC cord-005453-4057qib7 4094 6 17 17 CD cord-005453-4057qib7 4094 7 % % NN cord-005453-4057qib7 4094 8 [ [ -LRB- cord-005453-4057qib7 4094 9 95 95 CD cord-005453-4057qib7 4094 10 % % NN cord-005453-4057qib7 4094 11 CI CI NNP cord-005453-4057qib7 4094 12 , , , cord-005453-4057qib7 4094 13 8%-30 8%-30 CD cord-005453-4057qib7 4094 14 % % NN cord-005453-4057qib7 4094 15 ] ] -RRB- cord-005453-4057qib7 4095 1 for for IN cord-005453-4057qib7 4095 2 UA UA NNP cord-005453-4057qib7 4095 3 level level NN cord-005453-4057qib7 4095 4 ≤ ≤ NNP cord-005453-4057qib7 4095 5 3,1 3,1 CD cord-005453-4057qib7 4095 6 mg mg NNP cord-005453-4057qib7 4095 7 / / SYM cord-005453-4057qib7 4095 8 dL dl NN cord-005453-4057qib7 4096 1 [ [ -LRB- cord-005453-4057qib7 4096 2 p= p= NNP cord-005453-4057qib7 4096 3 0,046 0,046 CD cord-005453-4057qib7 4096 4 ] ] -RRB- cord-005453-4057qib7 4096 5 ) ) -RRB- cord-005453-4057qib7 4096 6 . . . cord-005453-4057qib7 4097 1 There there EX cord-005453-4057qib7 4097 2 was be VBD cord-005453-4057qib7 4097 3 a a DT cord-005453-4057qib7 4097 4 trend trend NN cord-005453-4057qib7 4097 5 for for IN cord-005453-4057qib7 4097 6 a a DT cord-005453-4057qib7 4097 7 higher high JJR cord-005453-4057qib7 4097 8 CI ci NN cord-005453-4057qib7 4097 9 of of IN cord-005453-4057qib7 4097 10 grade grade NN cord-005453-4057qib7 4097 11 II II NNP cord-005453-4057qib7 4097 12 - - HYPH cord-005453-4057qib7 4097 13 IV IV NNP cord-005453-4057qib7 4097 14 aGVHD aGVHD NNP cord-005453-4057qib7 4097 15 for for IN cord-005453-4057qib7 4097 16 the the DT cord-005453-4057qib7 4097 17 subgroup subgroup NN cord-005453-4057qib7 4097 18 of of IN cord-005453-4057qib7 4097 19 patients patient NNS cord-005453-4057qib7 4097 20 not not RB cord-005453-4057qib7 4097 21 treated treat VBN cord-005453-4057qib7 4097 22 with with IN cord-005453-4057qib7 4097 23 ATG ATG NNP cord-005453-4057qib7 4097 24 with with IN cord-005453-4057qib7 4097 25 UA UA NNP cord-005453-4057qib7 4098 1 < < XX cord-005453-4057qib7 4098 2 4,8 4,8 CD cord-005453-4057qib7 4099 1 mg mg NNP cord-005453-4057qib7 4099 2 / / SYM cord-005453-4057qib7 4099 3 dL dL NNP cord-005453-4057qib7 4099 4 ( ( -LRB- cord-005453-4057qib7 4099 5 48 48 CD cord-005453-4057qib7 4099 6 % % NN cord-005453-4057qib7 4099 7 vs vs IN cord-005453-4057qib7 4099 8 30 30 CD cord-005453-4057qib7 4099 9 % % NN cord-005453-4057qib7 4099 10 ; ; : cord-005453-4057qib7 4099 11 p= p= JJ cord-005453-4057qib7 4099 12 0,083 0,083 CD cord-005453-4057qib7 4099 13 ) ) -RRB- cord-005453-4057qib7 4099 14 on on IN cord-005453-4057qib7 4099 15 day day NN cord-005453-4057qib7 4099 16 -8 -8 NNPS cord-005453-4057qib7 4099 17 and and CC cord-005453-4057qib7 4099 18 a a DT cord-005453-4057qib7 4099 19 higher high JJR cord-005453-4057qib7 4099 20 NRM NRM NNP cord-005453-4057qib7 4099 21 with with IN cord-005453-4057qib7 4099 22 UA UA NNP cord-005453-4057qib7 4100 1 < < XX cord-005453-4057qib7 4100 2 2,85 2,85 CD cord-005453-4057qib7 4100 3 on on IN cord-005453-4057qib7 4100 4 day day NN cord-005453-4057qib7 4100 5 0 0 CD cord-005453-4057qib7 4100 6 ( ( -LRB- cord-005453-4057qib7 4100 7 50 50 CD cord-005453-4057qib7 4100 8 % % NN cord-005453-4057qib7 4100 9 vs vs IN cord-005453-4057qib7 4100 10 30 30 CD cord-005453-4057qib7 4100 11 % % NN cord-005453-4057qib7 4100 12 ; ; . cord-005453-4057qib7 4101 1 p=0,080 p=0,080 LS cord-005453-4057qib7 4101 2 ) ) -RRB- cord-005453-4057qib7 4101 3 . . . cord-005453-4057qib7 4102 1 Conclusions conclusion NNS cord-005453-4057qib7 4102 2 : : : cord-005453-4057qib7 4103 1 In in IN cord-005453-4057qib7 4103 2 our -PRON- PRP$ cord-005453-4057qib7 4103 3 study study NN cord-005453-4057qib7 4103 4 the the DT cord-005453-4057qib7 4103 5 UA UA NNP cord-005453-4057qib7 4103 6 levels level NNS cord-005453-4057qib7 4103 7 showed show VBD cord-005453-4057qib7 4103 8 no no DT cord-005453-4057qib7 4103 9 impact impact NN cord-005453-4057qib7 4103 10 on on IN cord-005453-4057qib7 4103 11 OS OS NNP cord-005453-4057qib7 4103 12 , , , cord-005453-4057qib7 4103 13 and and CC cord-005453-4057qib7 4103 14 only only RB cord-005453-4057qib7 4103 15 a a DT cord-005453-4057qib7 4103 16 tendency tendency NN cord-005453-4057qib7 4103 17 for for IN cord-005453-4057qib7 4103 18 CI CI NNP cord-005453-4057qib7 4103 19 of of IN cord-005453-4057qib7 4103 20 grades grade NNS cord-005453-4057qib7 4103 21 II II NNP cord-005453-4057qib7 4103 22 - - HYPH cord-005453-4057qib7 4103 23 IV IV NNP cord-005453-4057qib7 4103 24 aGVHD aGVHD NNP cord-005453-4057qib7 4103 25 grades grade NNS cord-005453-4057qib7 4103 26 II II NNP cord-005453-4057qib7 4103 27 - - HYPH cord-005453-4057qib7 4103 28 IV IV NNP cord-005453-4057qib7 4103 29 and and CC cord-005453-4057qib7 4103 30 NRM NRM NNP cord-005453-4057qib7 4103 31 for for IN cord-005453-4057qib7 4103 32 the the DT cord-005453-4057qib7 4103 33 subgroup subgroup NN cord-005453-4057qib7 4103 34 of of IN cord-005453-4057qib7 4103 35 patients patient NNS cord-005453-4057qib7 4103 36 not not RB cord-005453-4057qib7 4103 37 treated treat VBN cord-005453-4057qib7 4103 38 with with IN cord-005453-4057qib7 4103 39 ATG ATG NNP cord-005453-4057qib7 4103 40 . . . cord-005453-4057qib7 4104 1 Surprisingly surprisingly RB cord-005453-4057qib7 4104 2 , , , cord-005453-4057qib7 4104 3 high high JJ cord-005453-4057qib7 4104 4 levels level NNS cord-005453-4057qib7 4104 5 of of IN cord-005453-4057qib7 4104 6 UA UA NNP cord-005453-4057qib7 4104 7 at at IN cord-005453-4057qib7 4104 8 day day NN cord-005453-4057qib7 4104 9 +7 +7 CD cord-005453-4057qib7 4104 10 of of IN cord-005453-4057qib7 4104 11 HSCT HSCT NNP cord-005453-4057qib7 4104 12 were be VBD cord-005453-4057qib7 4104 13 associated associate VBN cord-005453-4057qib7 4104 14 with with IN cord-005453-4057qib7 4104 15 a a DT cord-005453-4057qib7 4104 16 significant significant JJ cord-005453-4057qib7 4104 17 higher high JJR cord-005453-4057qib7 4104 18 incidence incidence NN cord-005453-4057qib7 4104 19 of of IN cord-005453-4057qib7 4104 20 relapse relapse NN cord-005453-4057qib7 4104 21 . . . cord-005453-4057qib7 4105 1 Disclosure disclosure NN cord-005453-4057qib7 4105 2 : : : cord-005453-4057qib7 4105 3 DKMS DKMS NNP cord-005453-4057qib7 4105 4 Foundation Foundation NNP cord-005453-4057qib7 4105 5 , , , cord-005453-4057qib7 4105 6 PI14/01971 PI14/01971 NNP cord-005453-4057qib7 4106 1 ( ( -LRB- cord-005453-4057qib7 4106 2 Instituto Instituto NNP cord-005453-4057qib7 4106 3 Carlos Carlos NNP cord-005453-4057qib7 4106 4 III III NNP cord-005453-4057qib7 4106 5 ) ) -RRB- cord-005453-4057qib7 4107 1 and and CC cord-005453-4057qib7 4107 2 SGR288 SGR288 NNP cord-005453-4057qib7 4107 3 ( ( -LRB- cord-005453-4057qib7 4107 4 GRC GRC NNP cord-005453-4057qib7 4107 5 ) ) -RRB- cord-005453-4057qib7 4107 6 , , , cord-005453-4057qib7 4107 7 Generalitat Generalitat NNP cord-005453-4057qib7 4107 8 de de NNP cord-005453-4057qib7 4107 9 Catalunya Catalunya NNP cord-005453-4057qib7 4107 10 . . . cord-005453-4057qib7 4108 1 Background background NN cord-005453-4057qib7 4108 2 : : : cord-005453-4057qib7 4109 1 Veno Veno NNP cord-005453-4057qib7 4109 2 - - HYPH cord-005453-4057qib7 4109 3 occlusive occlusive JJ cord-005453-4057qib7 4109 4 disease disease NN cord-005453-4057qib7 4109 5 ( ( -LRB- cord-005453-4057qib7 4109 6 VOD VOD NNP cord-005453-4057qib7 4109 7 ) ) -RRB- cord-005453-4057qib7 4109 8 is be VBZ cord-005453-4057qib7 4109 9 an an DT cord-005453-4057qib7 4109 10 early early JJ cord-005453-4057qib7 4109 11 , , , cord-005453-4057qib7 4109 12 uncommon uncommon JJ cord-005453-4057qib7 4109 13 but but CC cord-005453-4057qib7 4109 14 serious serious JJ cord-005453-4057qib7 4109 15 complication complication NN cord-005453-4057qib7 4109 16 of of IN cord-005453-4057qib7 4109 17 stem stem NN cord-005453-4057qib7 4109 18 cell cell NN cord-005453-4057qib7 4109 19 transplantation transplantation NN cord-005453-4057qib7 4109 20 ( ( -LRB- cord-005453-4057qib7 4109 21 SCT SCT NNP cord-005453-4057qib7 4109 22 ) ) -RRB- cord-005453-4057qib7 4109 23 that that WDT cord-005453-4057qib7 4109 24 is be VBZ cord-005453-4057qib7 4109 25 associated associate VBN cord-005453-4057qib7 4109 26 with with IN cord-005453-4057qib7 4109 27 high high JJ cord-005453-4057qib7 4109 28 morbidity morbidity NN cord-005453-4057qib7 4109 29 and and CC cord-005453-4057qib7 4109 30 mortality mortality NN cord-005453-4057qib7 4109 31 . . . cord-005453-4057qib7 4110 1 Defibrotide Defibrotide NNP cord-005453-4057qib7 4110 2 is be VBZ cord-005453-4057qib7 4110 3 the the DT cord-005453-4057qib7 4110 4 only only RB cord-005453-4057qib7 4110 5 licensed license VBN cord-005453-4057qib7 4110 6 treatment treatment NN cord-005453-4057qib7 4110 7 for for IN cord-005453-4057qib7 4110 8 VOD VOD NNP cord-005453-4057qib7 4110 9 , , , cord-005453-4057qib7 4110 10 and and CC cord-005453-4057qib7 4110 11 time time NN cord-005453-4057qib7 4110 12 to to TO cord-005453-4057qib7 4110 13 start start VB cord-005453-4057qib7 4110 14 of of IN cord-005453-4057qib7 4110 15 treatment treatment NN cord-005453-4057qib7 4110 16 ( ( -LRB- cord-005453-4057qib7 4110 17 TsT TsT NNP cord-005453-4057qib7 4110 18 ) ) -RRB- cord-005453-4057qib7 4110 19 affects affect VBZ cord-005453-4057qib7 4110 20 outcomes outcome NNS cord-005453-4057qib7 4110 21 . . . cord-005453-4057qib7 4111 1 Minor minor JJ cord-005453-4057qib7 4111 2 differences difference NNS cord-005453-4057qib7 4111 3 exist exist VBP cord-005453-4057qib7 4111 4 between between IN cord-005453-4057qib7 4111 5 the the DT cord-005453-4057qib7 4111 6 Seattle Seattle NNP cord-005453-4057qib7 4111 7 , , , cord-005453-4057qib7 4111 8 Baltimore Baltimore NNP cord-005453-4057qib7 4111 9 and and CC cord-005453-4057qib7 4111 10 classical classical JJ cord-005453-4057qib7 4111 11 EBMT EBMT NNP cord-005453-4057qib7 4111 12 ( ( -LRB- cord-005453-4057qib7 4111 13 2016 2016 CD cord-005453-4057qib7 4111 14 ) ) -RRB- cord-005453-4057qib7 4111 15 criteria criterion NNS cord-005453-4057qib7 4111 16 , , , cord-005453-4057qib7 4111 17 which which WDT cord-005453-4057qib7 4111 18 may may MD cord-005453-4057qib7 4111 19 trigger trigger VB cord-005453-4057qib7 4111 20 different different JJ cord-005453-4057qib7 4111 21 start start NN cord-005453-4057qib7 4111 22 points point NNS cord-005453-4057qib7 4111 23 for for IN cord-005453-4057qib7 4111 24 treatment treatment NN cord-005453-4057qib7 4111 25 . . . cord-005453-4057qib7 4112 1 Late late JJ cord-005453-4057qib7 4112 2 onset onset NN cord-005453-4057qib7 4112 3 VOD vod NN cord-005453-4057qib7 4112 4 ( ( -LRB- cord-005453-4057qib7 4112 5 > > NFP cord-005453-4057qib7 4112 6 21 21 CD cord-005453-4057qib7 4112 7 days day NNS cord-005453-4057qib7 4112 8 ) ) -RRB- cord-005453-4057qib7 4112 9 is be VBZ cord-005453-4057qib7 4112 10 less less RBR cord-005453-4057qib7 4112 11 recognised recognised JJ cord-005453-4057qib7 4112 12 and and CC cord-005453-4057qib7 4112 13 we -PRON- PRP cord-005453-4057qib7 4112 14 hypothesize hypothesize VBP cord-005453-4057qib7 4112 15 , , , cord-005453-4057qib7 4112 16 may may MD cord-005453-4057qib7 4112 17 have have VB cord-005453-4057qib7 4112 18 worse bad JJR cord-005453-4057qib7 4112 19 outcomes outcome NNS cord-005453-4057qib7 4112 20 with with IN cord-005453-4057qib7 4112 21 longer long JJR cord-005453-4057qib7 4112 22 time time NN cord-005453-4057qib7 4112 23 to to IN cord-005453-4057qib7 4112 24 diagnosis diagnosis NN cord-005453-4057qib7 4112 25 , , , cord-005453-4057qib7 4112 26 and and CC cord-005453-4057qib7 4112 27 more more RBR cord-005453-4057qib7 4112 28 limited limited JJ cord-005453-4057qib7 4112 29 treatment treatment NN cord-005453-4057qib7 4112 30 options option NNS cord-005453-4057qib7 4112 31 across across IN cord-005453-4057qib7 4112 32 different different JJ cord-005453-4057qib7 4112 33 healthcare healthcare NN cord-005453-4057qib7 4112 34 systems system NNS cord-005453-4057qib7 4112 35 . . . cord-005453-4057qib7 4113 1 Methods method NNS cord-005453-4057qib7 4113 2 : : : cord-005453-4057qib7 4113 3 Electronic electronic JJ cord-005453-4057qib7 4113 4 patient patient NN cord-005453-4057qib7 4113 5 records record NNS cord-005453-4057qib7 4113 6 from from IN cord-005453-4057qib7 4113 7 Sept.2013 Sept.2013 NNP cord-005453-4057qib7 4114 1 -Oct.2018 -Oct.2018 NNP cord-005453-4057qib7 4115 1 at at IN cord-005453-4057qib7 4115 2 King´s King´s NNP cord-005453-4057qib7 4115 3 BMT BMT NNP cord-005453-4057qib7 4115 4 centre centre NN cord-005453-4057qib7 4115 5 and and CC cord-005453-4057qib7 4115 6 pharmacy pharmacy NN cord-005453-4057qib7 4115 7 databases database NNS cord-005453-4057qib7 4115 8 were be VBD cord-005453-4057qib7 4115 9 reviewed review VBN cord-005453-4057qib7 4115 10 , , , cord-005453-4057qib7 4115 11 timepoint timepoint NN cord-005453-4057qib7 4115 12 to to IN cord-005453-4057qib7 4115 13 clinical clinical JJ cord-005453-4057qib7 4115 14 and and CC cord-005453-4057qib7 4115 15 bio bio JJ cord-005453-4057qib7 4115 16 - - JJ cord-005453-4057qib7 4115 17 chemical chemical JJ cord-005453-4057qib7 4115 18 manifestation manifestation NN cord-005453-4057qib7 4115 19 of of IN cord-005453-4057qib7 4115 20 VOD VOD NNP cord-005453-4057qib7 4115 21 , , , cord-005453-4057qib7 4115 22 diagnosis diagnosis NN cord-005453-4057qib7 4115 23 , , , cord-005453-4057qib7 4115 24 TsT tst NN cord-005453-4057qib7 4115 25 , , , cord-005453-4057qib7 4115 26 survival survival NN cord-005453-4057qib7 4115 27 and and CC cord-005453-4057qib7 4115 28 longterm longterm JJ cord-005453-4057qib7 4115 29 outcomes outcome NNS cord-005453-4057qib7 4115 30 were be VBD cord-005453-4057qib7 4115 31 analysed analyse VBN cord-005453-4057qib7 4115 32 . . . cord-005453-4057qib7 4116 1 Results result NNS cord-005453-4057qib7 4116 2 : : : cord-005453-4057qib7 4116 3 30 30 CD cord-005453-4057qib7 4116 4 of of IN cord-005453-4057qib7 4116 5 the the DT cord-005453-4057qib7 4116 6 532 532 CD cord-005453-4057qib7 4116 7 patients(5.6 patients(5.6 NNP cord-005453-4057qib7 4116 8 % % NN cord-005453-4057qib7 4116 9 ) ) -RRB- cord-005453-4057qib7 4116 10 who who WP cord-005453-4057qib7 4116 11 underwent undergo VBD cord-005453-4057qib7 4116 12 an an DT cord-005453-4057qib7 4116 13 allogeneic allogeneic JJ cord-005453-4057qib7 4116 14 SCT SCT NNP cord-005453-4057qib7 4116 15 , , , cord-005453-4057qib7 4116 16 developed develop VBD cord-005453-4057qib7 4116 17 VOD VOD NNP cord-005453-4057qib7 4116 18 , , , cord-005453-4057qib7 4116 19 including include VBG cord-005453-4057qib7 4116 20 2 2 CD cord-005453-4057qib7 4116 21 paediatric paediatric JJ cord-005453-4057qib7 4116 22 cases case NNS cord-005453-4057qib7 4116 23 . . . cord-005453-4057qib7 4117 1 None none NN cord-005453-4057qib7 4117 2 of of IN cord-005453-4057qib7 4117 3 the the DT cord-005453-4057qib7 4117 4 Autologous autologous JJ cord-005453-4057qib7 4117 5 SCT SCT NNP cord-005453-4057qib7 4117 6 patients patient NNS cord-005453-4057qib7 4117 7 developed develop VBD cord-005453-4057qib7 4117 8 VOD VOD NNP cord-005453-4057qib7 4117 9 . . . cord-005453-4057qib7 4118 1 The the DT cord-005453-4057qib7 4118 2 paediatric paediatric JJ cord-005453-4057qib7 4118 3 and and CC cord-005453-4057qib7 4118 4 Autologous autologous JJ cord-005453-4057qib7 4118 5 SCT SCT NNP cord-005453-4057qib7 4118 6 patients patient NNS cord-005453-4057qib7 4118 7 were be VBD cord-005453-4057qib7 4118 8 not not RB cord-005453-4057qib7 4118 9 analysed analyse VBN cord-005453-4057qib7 4118 10 any any RB cord-005453-4057qib7 4118 11 further further RB cord-005453-4057qib7 4118 12 . . . cord-005453-4057qib7 4119 1 28 28 CD cord-005453-4057qib7 4119 2 adult adult NN cord-005453-4057qib7 4119 3 patients patient NNS cord-005453-4057qib7 4119 4 ( ( -LRB- cord-005453-4057qib7 4119 5 Male=22;78.5 Male=22;78.5 NNP cord-005453-4057qib7 4119 6 % % NN cord-005453-4057qib7 4119 7 ) ) -RRB- cord-005453-4057qib7 4119 8 developed develop VBD cord-005453-4057qib7 4119 9 VOD VOD NNP cord-005453-4057qib7 4119 10 at at IN cord-005453-4057qib7 4119 11 a a DT cord-005453-4057qib7 4119 12 median median JJ cord-005453-4057qib7 4119 13 age age NN cord-005453-4057qib7 4119 14 of of IN cord-005453-4057qib7 4119 15 56 56 CD cord-005453-4057qib7 4119 16 years(range years(range CD cord-005453-4057qib7 4119 17 26 26 CD cord-005453-4057qib7 4119 18 - - SYM cord-005453-4057qib7 4119 19 72 72 CD cord-005453-4057qib7 4119 20 ) ) -RRB- cord-005453-4057qib7 4119 21 , , , cord-005453-4057qib7 4119 22 of of IN cord-005453-4057qib7 4119 23 whom whom WP cord-005453-4057qib7 4119 24 21 21 CD cord-005453-4057qib7 4119 25 developed develop VBD cord-005453-4057qib7 4119 26 < < NNP cord-005453-4057qib7 4119 27 21 21 CD cord-005453-4057qib7 4119 28 days day NNS cord-005453-4057qib7 4119 29 and and CC cord-005453-4057qib7 4119 30 7 7 CD cord-005453-4057qib7 4119 31 patients patient NNS cord-005453-4057qib7 4119 32 had have VBD cord-005453-4057qib7 4119 33 late late JJ cord-005453-4057qib7 4119 34 - - HYPH cord-005453-4057qib7 4119 35 onset onset NN cord-005453-4057qib7 4119 36 VOD vod NN cord-005453-4057qib7 4119 37 as as IN cord-005453-4057qib7 4119 38 per per IN cord-005453-4057qib7 4119 39 EBMT EBMT NNP cord-005453-4057qib7 4120 1 criteria(range criteria(range PRP$ cord-005453-4057qib7 4120 2 22 22 CD cord-005453-4057qib7 4120 3 - - SYM cord-005453-4057qib7 4120 4 93 93 CD cord-005453-4057qib7 4120 5 days day NNS cord-005453-4057qib7 4120 6 ) ) -RRB- cord-005453-4057qib7 4120 7 . . . cord-005453-4057qib7 4121 1 24 24 CD cord-005453-4057qib7 4121 2 cases case NNS cord-005453-4057qib7 4121 3 classed class VBN cord-005453-4057qib7 4121 4 as as IN cord-005453-4057qib7 4121 5 severe severe JJ cord-005453-4057qib7 4121 6 and and CC cord-005453-4057qib7 4121 7 4 4 CD cord-005453-4057qib7 4121 8 as as IN cord-005453-4057qib7 4121 9 moderate moderate JJ cord-005453-4057qib7 4121 10 VOD VOD NNP cord-005453-4057qib7 4121 11 . . . cord-005453-4057qib7 4122 1 10 10 CD cord-005453-4057qib7 4122 2 patients patient NNS cord-005453-4057qib7 4122 3 received receive VBD cord-005453-4057qib7 4122 4 Defibrotide Defibrotide NNP cord-005453-4057qib7 4122 5 at at IN cord-005453-4057qib7 4122 6 diagnosis diagnosis NN cord-005453-4057qib7 4122 7 , , , cord-005453-4057qib7 4122 8 7 7 CD cord-005453-4057qib7 4122 9 patients patient NNS cord-005453-4057qib7 4122 10 within within IN cord-005453-4057qib7 4122 11 3 3 CD cord-005453-4057qib7 4122 12 days day NNS cord-005453-4057qib7 4122 13 , , , cord-005453-4057qib7 4122 14 5 5 CD cord-005453-4057qib7 4122 15 patients patient NNS cord-005453-4057qib7 4122 16 between between IN cord-005453-4057qib7 4122 17 4 4 CD cord-005453-4057qib7 4122 18 - - SYM cord-005453-4057qib7 4122 19 7 7 CD cord-005453-4057qib7 4122 20 days day NNS cord-005453-4057qib7 4122 21 , , , cord-005453-4057qib7 4122 22 and and CC cord-005453-4057qib7 4122 23 6 6 CD cord-005453-4057qib7 4122 24 patients patient NNS cord-005453-4057qib7 4122 25 received receive VBD cord-005453-4057qib7 4122 26 treatment treatment NN cord-005453-4057qib7 4122 27 after after IN cord-005453-4057qib7 4122 28 7 7 CD cord-005453-4057qib7 4122 29 days day NNS cord-005453-4057qib7 4122 30 . . . cord-005453-4057qib7 4123 1 Overall overall JJ cord-005453-4057qib7 4123 2 mortality mortality NN cord-005453-4057qib7 4123 3 for for IN cord-005453-4057qib7 4123 4 this this DT cord-005453-4057qib7 4123 5 cohort cohort NN cord-005453-4057qib7 4123 6 was be VBD cord-005453-4057qib7 4123 7 50%(14/28 50%(14/28 CD cord-005453-4057qib7 4123 8 ) ) -RRB- cord-005453-4057qib7 4123 9 . . . cord-005453-4057qib7 4124 1 12/21 12/21 CD cord-005453-4057qib7 4124 2 ( ( -LRB- cord-005453-4057qib7 4124 3 57.1 57.1 CD cord-005453-4057qib7 4124 4 % % NN cord-005453-4057qib7 4124 5 ) ) -RRB- cord-005453-4057qib7 4124 6 of of IN cord-005453-4057qib7 4124 7 patients patient NNS cord-005453-4057qib7 4124 8 with with IN cord-005453-4057qib7 4124 9 early early JJ cord-005453-4057qib7 4124 10 onset onset NN cord-005453-4057qib7 4124 11 VOD vod NN cord-005453-4057qib7 4124 12 and and CC cord-005453-4057qib7 4124 13 2/7(28.5 2/7(28.5 CD cord-005453-4057qib7 4124 14 % % NN cord-005453-4057qib7 4124 15 ) ) -RRB- cord-005453-4057qib7 4124 16 patients patient NNS cord-005453-4057qib7 4124 17 with with IN cord-005453-4057qib7 4124 18 late late JJ cord-005453-4057qib7 4124 19 - - HYPH cord-005453-4057qib7 4124 20 onset onset NN cord-005453-4057qib7 4124 21 VOD VOD NNP cord-005453-4057qib7 4124 22 died die VBD cord-005453-4057qib7 4124 23 . . . cord-005453-4057qib7 4125 1 Of of IN cord-005453-4057qib7 4125 2 the the DT cord-005453-4057qib7 4125 3 14 14 CD cord-005453-4057qib7 4125 4 deaths death NNS cord-005453-4057qib7 4125 5 , , , cord-005453-4057qib7 4125 6 10 10 CD cord-005453-4057qib7 4125 7 died die VBD cord-005453-4057qib7 4125 8 of of IN cord-005453-4057qib7 4125 9 liver liver NN cord-005453-4057qib7 4125 10 failure failure NN cord-005453-4057qib7 4125 11 and and CC cord-005453-4057qib7 4125 12 a a DT cord-005453-4057qib7 4125 13 further further JJ cord-005453-4057qib7 4125 14 2 2 CD cord-005453-4057qib7 4125 15 patients patient NNS cord-005453-4057qib7 4125 16 had have VBD cord-005453-4057qib7 4125 17 VOD VOD NNP cord-005453-4057qib7 4125 18 as as IN cord-005453-4057qib7 4125 19 a a DT cord-005453-4057qib7 4125 20 likely likely JJ cord-005453-4057qib7 4125 21 contributing contribute VBG cord-005453-4057qib7 4125 22 factor factor NN cord-005453-4057qib7 4125 23 in in IN cord-005453-4057qib7 4125 24 their -PRON- PRP$ cord-005453-4057qib7 4125 25 deaths death NNS cord-005453-4057qib7 4125 26 . . . cord-005453-4057qib7 4126 1 1 1 CD cord-005453-4057qib7 4126 2 patient patient NN cord-005453-4057qib7 4126 3 died die VBD cord-005453-4057qib7 4126 4 with with IN cord-005453-4057qib7 4126 5 subarachnoid subarachnoid NN cord-005453-4057qib7 4126 6 haemorrhage haemorrhage NN cord-005453-4057qib7 4126 7 and and CC cord-005453-4057qib7 4126 8 1 1 CD cord-005453-4057qib7 4126 9 with with IN cord-005453-4057qib7 4126 10 relapsed relapsed JJ cord-005453-4057qib7 4126 11 disease disease NN cord-005453-4057qib7 4126 12 . . . cord-005453-4057qib7 4127 1 Patients patient NNS cord-005453-4057qib7 4127 2 that that WDT cord-005453-4057qib7 4127 3 received receive VBD cord-005453-4057qib7 4127 4 Defibrotide Defibrotide NNP cord-005453-4057qib7 4127 5 after after IN cord-005453-4057qib7 4127 6 7 7 CD cord-005453-4057qib7 4127 7 days day NNS cord-005453-4057qib7 4127 8 , , , cord-005453-4057qib7 4127 9 5/6 5/6 CD cord-005453-4057qib7 4127 10 patients(83.3 patients(83.3 NNP cord-005453-4057qib7 4127 11 % % NN cord-005453-4057qib7 4127 12 ) ) -RRB- cord-005453-4057qib7 4127 13 died die VBD cord-005453-4057qib7 4127 14 , , , cord-005453-4057qib7 4127 15 as as IN cord-005453-4057qib7 4127 16 compared compare VBN cord-005453-4057qib7 4127 17 to to IN cord-005453-4057qib7 4127 18 3/5(60 3/5(60 CD cord-005453-4057qib7 4127 19 % % NN cord-005453-4057qib7 4127 20 ) ) -RRB- cord-005453-4057qib7 4127 21 for for IN cord-005453-4057qib7 4127 22 treatments treatment NNS cord-005453-4057qib7 4127 23 between between IN cord-005453-4057qib7 4127 24 4 4 CD cord-005453-4057qib7 4127 25 - - SYM cord-005453-4057qib7 4127 26 7 7 CD cord-005453-4057qib7 4127 27 days day NNS cord-005453-4057qib7 4127 28 , , , cord-005453-4057qib7 4127 29 6/17(35.2 6/17(35.2 CD cord-005453-4057qib7 4127 30 % % NN cord-005453-4057qib7 4127 31 ) ) -RRB- cord-005453-4057qib7 4127 32 for for IN cord-005453-4057qib7 4127 33 treatments treatment NNS cord-005453-4057qib7 4127 34 within within IN cord-005453-4057qib7 4127 35 3 3 CD cord-005453-4057qib7 4127 36 days day NNS cord-005453-4057qib7 4127 37 . . . cord-005453-4057qib7 4128 1 The the DT cord-005453-4057qib7 4128 2 lone lone JJ cord-005453-4057qib7 4128 3 surviving survive VBG cord-005453-4057qib7 4128 4 patient patient NN cord-005453-4057qib7 4128 5 who who WP cord-005453-4057qib7 4128 6 received receive VBD cord-005453-4057qib7 4128 7 treatment treatment NN cord-005453-4057qib7 4128 8 after after IN cord-005453-4057qib7 4128 9 7 7 CD cord-005453-4057qib7 4128 10 days day NNS cord-005453-4057qib7 4128 11 has have VBZ cord-005453-4057qib7 4128 12 severe severe JJ cord-005453-4057qib7 4128 13 chronic chronic JJ cord-005453-4057qib7 4128 14 liver liver NN cord-005453-4057qib7 4128 15 disease disease NN cord-005453-4057qib7 4128 16 and and CC cord-005453-4057qib7 4128 17 it -PRON- PRP cord-005453-4057qib7 4128 18 's be VBZ cord-005453-4057qib7 4128 19 complications complication NNS cord-005453-4057qib7 4128 20 . . . cord-005453-4057qib7 4129 1 Of of IN cord-005453-4057qib7 4129 2 the the DT cord-005453-4057qib7 4129 3 21 21 CD cord-005453-4057qib7 4129 4 patients patient NNS cord-005453-4057qib7 4129 5 who who WP cord-005453-4057qib7 4129 6 fit fit VBP cord-005453-4057qib7 4129 7 Seattle Seattle NNP cord-005453-4057qib7 4129 8 criteria criterion NNS cord-005453-4057qib7 4129 9 for for IN cord-005453-4057qib7 4129 10 early early JJ cord-005453-4057qib7 4129 11 - - HYPH cord-005453-4057qib7 4129 12 onset onset NN cord-005453-4057qib7 4129 13 VOD vod NN cord-005453-4057qib7 4129 14 , , , cord-005453-4057qib7 4129 15 only only RB cord-005453-4057qib7 4129 16 6 6 CD cord-005453-4057qib7 4129 17 fit fit VBP cord-005453-4057qib7 4129 18 the the DT cord-005453-4057qib7 4129 19 Baltimore Baltimore NNP cord-005453-4057qib7 4129 20 or or CC cord-005453-4057qib7 4129 21 EBMT EBMT NNP cord-005453-4057qib7 4129 22 criteria criterion NNS cord-005453-4057qib7 4129 23 for for IN cord-005453-4057qib7 4129 24 classical classical JJ cord-005453-4057qib7 4129 25 VOD vod NN cord-005453-4057qib7 4129 26 . . . cord-005453-4057qib7 4130 1 4 4 CD cord-005453-4057qib7 4130 2 of of IN cord-005453-4057qib7 4130 3 these these DT cord-005453-4057qib7 4130 4 6 6 CD cord-005453-4057qib7 4130 5 patients patient NNS cord-005453-4057qib7 4130 6 met meet VBD cord-005453-4057qib7 4130 7 the the DT cord-005453-4057qib7 4130 8 Baltimore Baltimore NNP cord-005453-4057qib7 4130 9 criteria criterion NNS cord-005453-4057qib7 4130 10 later later RB cord-005453-4057qib7 4130 11 than than IN cord-005453-4057qib7 4130 12 the the DT cord-005453-4057qib7 4130 13 Seattle Seattle NNP cord-005453-4057qib7 4130 14 criteria criterion NNS cord-005453-4057qib7 4130 15 were be VBD cord-005453-4057qib7 4130 16 met(range met(range NN cord-005453-4057qib7 4130 17 = = SYM cord-005453-4057qib7 4130 18 2 2 CD cord-005453-4057qib7 4130 19 - - SYM cord-005453-4057qib7 4130 20 9 9 CD cord-005453-4057qib7 4130 21 days day NNS cord-005453-4057qib7 4130 22 ) ) -RRB- cord-005453-4057qib7 4130 23 . . . cord-005453-4057qib7 4131 1 Conclusions conclusion NNS cord-005453-4057qib7 4131 2 : : : cord-005453-4057qib7 4132 1 VOD VOD NNP cord-005453-4057qib7 4132 2 carries carry VBZ cord-005453-4057qib7 4132 3 high high JJ cord-005453-4057qib7 4132 4 morbidity morbidity NN cord-005453-4057qib7 4132 5 and and CC cord-005453-4057qib7 4132 6 mortality mortality NN cord-005453-4057qib7 4132 7 , , , cord-005453-4057qib7 4132 8 and and CC cord-005453-4057qib7 4132 9 beyond beyond IN cord-005453-4057qib7 4132 10 the the DT cord-005453-4057qib7 4132 11 known know VBN cord-005453-4057qib7 4132 12 risk risk NN cord-005453-4057qib7 4132 13 factors factor NNS cord-005453-4057qib7 4132 14 and and CC cord-005453-4057qib7 4132 15 with with IN cord-005453-4057qib7 4132 16 the the DT cord-005453-4057qib7 4132 17 caveat caveat NN cord-005453-4057qib7 4132 18 of of IN cord-005453-4057qib7 4132 19 limited limited JJ cord-005453-4057qib7 4132 20 numbers number NNS cord-005453-4057qib7 4132 21 in in IN cord-005453-4057qib7 4132 22 this this DT cord-005453-4057qib7 4132 23 study study NN cord-005453-4057qib7 4132 24 , , , cord-005453-4057qib7 4132 25 we -PRON- PRP cord-005453-4057qib7 4132 26 strongly strongly RB cord-005453-4057qib7 4132 27 suspect suspect VBP cord-005453-4057qib7 4132 28 this this DT cord-005453-4057qib7 4132 29 is be VBZ cord-005453-4057qib7 4132 30 further further RB cord-005453-4057qib7 4132 31 increased increase VBN cord-005453-4057qib7 4132 32 when when WRB cord-005453-4057qib7 4132 33 time time NN cord-005453-4057qib7 4132 34 to to IN cord-005453-4057qib7 4132 35 definitive definitive JJ cord-005453-4057qib7 4132 36 treatment treatment NN cord-005453-4057qib7 4132 37 with with IN cord-005453-4057qib7 4132 38 Defibrotide Defibrotide NNP cord-005453-4057qib7 4132 39 is be VBZ cord-005453-4057qib7 4132 40 delayed delay VBN cord-005453-4057qib7 4132 41 , , , cord-005453-4057qib7 4132 42 particularly particularly RB cord-005453-4057qib7 4132 43 beyond beyond IN cord-005453-4057qib7 4132 44 7 7 CD cord-005453-4057qib7 4132 45 days day NNS cord-005453-4057qib7 4132 46 . . . cord-005453-4057qib7 4133 1 Nearly nearly RB cord-005453-4057qib7 4133 2 a a DT cord-005453-4057qib7 4133 3 quarter quarter NN cord-005453-4057qib7 4133 4 of of IN cord-005453-4057qib7 4133 5 cases case NNS cord-005453-4057qib7 4133 6 with with IN cord-005453-4057qib7 4133 7 VOD VOD NNP cord-005453-4057qib7 4133 8 are be VBP cord-005453-4057qib7 4133 9 late late JJ cord-005453-4057qib7 4133 10 - - HYPH cord-005453-4057qib7 4133 11 onset onset NN cord-005453-4057qib7 4133 12 as as IN cord-005453-4057qib7 4133 13 per per IN cord-005453-4057qib7 4133 14 classical classical JJ cord-005453-4057qib7 4133 15 EBMT EBMT NNP cord-005453-4057qib7 4133 16 criteria criterion NNS cord-005453-4057qib7 4133 17 . . . cord-005453-4057qib7 4134 1 However however RB cord-005453-4057qib7 4134 2 contrary contrary JJ cord-005453-4057qib7 4134 3 to to IN cord-005453-4057qib7 4134 4 our -PRON- PRP$ cord-005453-4057qib7 4134 5 hypothesis hypothesis NN cord-005453-4057qib7 4134 6 , , , cord-005453-4057qib7 4134 7 their -PRON- PRP$ cord-005453-4057qib7 4134 8 overall overall JJ cord-005453-4057qib7 4134 9 outcomes outcome NNS cord-005453-4057qib7 4134 10 and and CC cord-005453-4057qib7 4134 11 mortality mortality NN cord-005453-4057qib7 4134 12 do do VBP cord-005453-4057qib7 4134 13 not not RB cord-005453-4057qib7 4134 14 appear appear VB cord-005453-4057qib7 4134 15 worse bad JJR cord-005453-4057qib7 4134 16 , , , cord-005453-4057qib7 4134 17 with with IN cord-005453-4057qib7 4134 18 time time NN cord-005453-4057qib7 4134 19 to to IN cord-005453-4057qib7 4134 20 treatment treatment NN cord-005453-4057qib7 4134 21 again again RB cord-005453-4057qib7 4134 22 emerging emerge VBG cord-005453-4057qib7 4134 23 as as IN cord-005453-4057qib7 4134 24 a a DT cord-005453-4057qib7 4134 25 strong strong JJ cord-005453-4057qib7 4134 26 predictive predictive JJ cord-005453-4057qib7 4134 27 factor factor NN cord-005453-4057qib7 4134 28 . . . cord-005453-4057qib7 4135 1 Conditioning conditioning NN cord-005453-4057qib7 4135 2 treatment treatment NN cord-005453-4057qib7 4135 3 related relate VBN cord-005453-4057qib7 4135 4 factors factor NNS cord-005453-4057qib7 4135 5 , , , cord-005453-4057qib7 4135 6 which which WDT cord-005453-4057qib7 4135 7 play play VBP cord-005453-4057qib7 4135 8 a a DT cord-005453-4057qib7 4135 9 stronger strong JJR cord-005453-4057qib7 4135 10 role role NN cord-005453-4057qib7 4135 11 in in IN cord-005453-4057qib7 4135 12 endothelial endothelial JJ cord-005453-4057qib7 4135 13 dysfunction dysfunction NN cord-005453-4057qib7 4135 14 in in IN cord-005453-4057qib7 4135 15 the the DT cord-005453-4057qib7 4135 16 hepato hepato NN cord-005453-4057qib7 4135 17 - - HYPH cord-005453-4057qib7 4135 18 portal portal JJ cord-005453-4057qib7 4135 19 circulation circulation NN cord-005453-4057qib7 4135 20 , , , cord-005453-4057qib7 4135 21 may may MD cord-005453-4057qib7 4135 22 not not RB cord-005453-4057qib7 4135 23 be be VB cord-005453-4057qib7 4135 24 as as RB cord-005453-4057qib7 4135 25 much much JJ cord-005453-4057qib7 4135 26 at at IN cord-005453-4057qib7 4135 27 play play NN cord-005453-4057qib7 4135 28 , , , cord-005453-4057qib7 4135 29 perhaps perhaps RB cord-005453-4057qib7 4135 30 for for IN cord-005453-4057qib7 4135 31 late late JJ cord-005453-4057qib7 4135 32 - - HYPH cord-005453-4057qib7 4135 33 onset onset NN cord-005453-4057qib7 4135 34 disease disease NN cord-005453-4057qib7 4135 35 . . . cord-005453-4057qib7 4136 1 Uniformity uniformity NN cord-005453-4057qib7 4136 2 in in IN cord-005453-4057qib7 4136 3 the the DT cord-005453-4057qib7 4136 4 use use NN cord-005453-4057qib7 4136 5 of of IN cord-005453-4057qib7 4136 6 diagnostic diagnostic JJ cord-005453-4057qib7 4136 7 criteria criterion NNS cord-005453-4057qib7 4136 8 , , , cord-005453-4057qib7 4136 9 and and CC cord-005453-4057qib7 4136 10 high high JJ cord-005453-4057qib7 4136 11 degree degree NN cord-005453-4057qib7 4136 12 of of IN cord-005453-4057qib7 4136 13 vigilance vigilance NN cord-005453-4057qib7 4136 14 , , , cord-005453-4057qib7 4136 15 even even RB cord-005453-4057qib7 4136 16 beyond beyond IN cord-005453-4057qib7 4136 17 21 21 CD cord-005453-4057qib7 4136 18 days day NNS cord-005453-4057qib7 4136 19 , , , cord-005453-4057qib7 4136 20 leading lead VBG cord-005453-4057qib7 4136 21 to to IN cord-005453-4057qib7 4136 22 early early JJ cord-005453-4057qib7 4136 23 treatments treatment NNS cord-005453-4057qib7 4136 24 may may MD cord-005453-4057qib7 4136 25 improve improve VB cord-005453-4057qib7 4136 26 outcomes outcome NNS cord-005453-4057qib7 4136 27 in in IN cord-005453-4057qib7 4136 28 VOD VOD NNP cord-005453-4057qib7 4136 29 . . . cord-005453-4057qib7 4137 1 Disclosure disclosure NN cord-005453-4057qib7 4137 2 : : : cord-005453-4057qib7 4137 3 Nothing nothing NN cord-005453-4057qib7 4137 4 to to TO cord-005453-4057qib7 4137 5 declare declare VB cord-005453-4057qib7 4137 6 Background background NN cord-005453-4057qib7 4137 7 : : : cord-005453-4057qib7 4137 8 HSCT HSCT NNP cord-005453-4057qib7 4137 9 - - HYPH cord-005453-4057qib7 4137 10 associated associate VBN cord-005453-4057qib7 4137 11 thrombotic thrombotic JJ cord-005453-4057qib7 4137 12 microangiopathy microangiopathy NNP cord-005453-4057qib7 4137 13 ( ( -LRB- cord-005453-4057qib7 4137 14 TA TA NNP cord-005453-4057qib7 4137 15 - - HYPH cord-005453-4057qib7 4137 16 TMA TMA NNP cord-005453-4057qib7 4137 17 ) ) -RRB- cord-005453-4057qib7 4137 18 affects affect VBZ cord-005453-4057qib7 4137 19 10 10 CD cord-005453-4057qib7 4137 20 - - SYM cord-005453-4057qib7 4137 21 30 30 CD cord-005453-4057qib7 4137 22 % % NN cord-005453-4057qib7 4137 23 of of IN cord-005453-4057qib7 4137 24 patients patient NNS cord-005453-4057qib7 4137 25 receiving receive VBG cord-005453-4057qib7 4137 26 an an DT cord-005453-4057qib7 4137 27 allogenic allogenic JJ cord-005453-4057qib7 4137 28 SCT sct NN cord-005453-4057qib7 4137 29 , , , cord-005453-4057qib7 4137 30 with with IN cord-005453-4057qib7 4137 31 a a DT cord-005453-4057qib7 4137 32 high high JJ cord-005453-4057qib7 4137 33 mortality mortality NN cord-005453-4057qib7 4137 34 up up IN cord-005453-4057qib7 4137 35 to to TO cord-005453-4057qib7 4137 36 80 80 CD cord-005453-4057qib7 4137 37 - - SYM cord-005453-4057qib7 4137 38 90 90 CD cord-005453-4057qib7 4137 39 % % NN cord-005453-4057qib7 4137 40 in in IN cord-005453-4057qib7 4137 41 severe severe JJ cord-005453-4057qib7 4137 42 cases case NNS cord-005453-4057qib7 4137 43 . . . cord-005453-4057qib7 4138 1 Endothelial endothelial JJ cord-005453-4057qib7 4138 2 injury injury NN cord-005453-4057qib7 4138 3 mediated mediate VBN cord-005453-4057qib7 4138 4 by by IN cord-005453-4057qib7 4138 5 complement complement JJ cord-005453-4057qib7 4138 6 activation activation NN cord-005453-4057qib7 4138 7 has have VBZ cord-005453-4057qib7 4138 8 been be VBN cord-005453-4057qib7 4138 9 atribuited atribuite VBN cord-005453-4057qib7 4138 10 a a DT cord-005453-4057qib7 4138 11 major major JJ cord-005453-4057qib7 4138 12 role role NN cord-005453-4057qib7 4138 13 in in IN cord-005453-4057qib7 4138 14 the the DT cord-005453-4057qib7 4138 15 pathogenesis pathogenesis NN cord-005453-4057qib7 4138 16 , , , cord-005453-4057qib7 4138 17 and and CC cord-005453-4057qib7 4138 18 blockade blockade NN cord-005453-4057qib7 4138 19 of of IN cord-005453-4057qib7 4138 20 C5 C5 NNP cord-005453-4057qib7 4138 21 with with IN cord-005453-4057qib7 4138 22 Eculizumab Eculizumab NNP cord-005453-4057qib7 4138 23 offers offer VBZ cord-005453-4057qib7 4138 24 promising promising JJ cord-005453-4057qib7 4138 25 results result NNS cord-005453-4057qib7 4138 26 . . . cord-005453-4057qib7 4139 1 Methods method NNS cord-005453-4057qib7 4139 2 : : : cord-005453-4057qib7 4139 3 We -PRON- PRP cord-005453-4057qib7 4139 4 present present VBP cord-005453-4057qib7 4139 5 our -PRON- PRP$ cord-005453-4057qib7 4139 6 experience experience NN cord-005453-4057qib7 4139 7 with with IN cord-005453-4057qib7 4139 8 6 6 CD cord-005453-4057qib7 4139 9 pediatric pediatric JJ cord-005453-4057qib7 4139 10 cases case NNS cord-005453-4057qib7 4139 11 of of IN cord-005453-4057qib7 4139 12 TA TA NNP cord-005453-4057qib7 4139 13 - - HYPH cord-005453-4057qib7 4139 14 TMA TMA NNP cord-005453-4057qib7 4139 15 treated treat VBN cord-005453-4057qib7 4139 16 with with IN cord-005453-4057qib7 4139 17 Eculizumab Eculizumab NNP cord-005453-4057qib7 4139 18 . . . cord-005453-4057qib7 4140 1 The the DT cord-005453-4057qib7 4140 2 diagnosis diagnosis NN cord-005453-4057qib7 4140 3 of of IN cord-005453-4057qib7 4140 4 TA TA NNP cord-005453-4057qib7 4140 5 - - HYPH cord-005453-4057qib7 4140 6 TMA TMA NNP cord-005453-4057qib7 4140 7 was be VBD cord-005453-4057qib7 4140 8 stablished stablishe VBN cord-005453-4057qib7 4140 9 attending attend VBG cord-005453-4057qib7 4140 10 to to IN cord-005453-4057qib7 4140 11 Jodele Jodele NNP cord-005453-4057qib7 4140 12 et et NNP cord-005453-4057qib7 4140 13 al al NNP cord-005453-4057qib7 4140 14 criteria criterion NNS cord-005453-4057qib7 4140 15 . . . cord-005453-4057qib7 4141 1 Clinical clinical JJ cord-005453-4057qib7 4141 2 data datum NNS cord-005453-4057qib7 4141 3 were be VBD cord-005453-4057qib7 4141 4 collected collect VBN cord-005453-4057qib7 4141 5 retrospectively retrospectively RB cord-005453-4057qib7 4141 6 from from IN cord-005453-4057qib7 4141 7 medical medical JJ cord-005453-4057qib7 4141 8 records record NNS cord-005453-4057qib7 4141 9 . . . cord-005453-4057qib7 4142 1 Results result NNS cord-005453-4057qib7 4142 2 : : : cord-005453-4057qib7 4143 1 All all DT cord-005453-4057qib7 4143 2 cases case NNS cord-005453-4057qib7 4143 3 were be VBD cord-005453-4057qib7 4143 4 diagnosed diagnose VBN cord-005453-4057qib7 4143 5 between between IN cord-005453-4057qib7 4143 6 August August NNP cord-005453-4057qib7 4143 7 2016 2016 CD cord-005453-4057qib7 4143 8 and and CC cord-005453-4057qib7 4143 9 April April NNP cord-005453-4057qib7 4143 10 2018 2018 CD cord-005453-4057qib7 4143 11 , , , cord-005453-4057qib7 4143 12 with with IN cord-005453-4057qib7 4143 13 a a DT cord-005453-4057qib7 4143 14 median median JJ cord-005453-4057qib7 4143 15 age age NN cord-005453-4057qib7 4143 16 of of IN cord-005453-4057qib7 4143 17 11 11 CD cord-005453-4057qib7 4143 18 years year NNS cord-005453-4057qib7 4143 19 ( ( -LRB- cord-005453-4057qib7 4143 20 2.5 2.5 CD cord-005453-4057qib7 4143 21 -17 -17 CD cord-005453-4057qib7 4143 22 ) ) -RRB- cord-005453-4057qib7 4143 23 at at IN cord-005453-4057qib7 4143 24 time time NN cord-005453-4057qib7 4143 25 of of IN cord-005453-4057qib7 4143 26 diagnosis diagnosis NN cord-005453-4057qib7 4143 27 . . . cord-005453-4057qib7 4144 1 Primary primary JJ cord-005453-4057qib7 4144 2 disease disease NN cord-005453-4057qib7 4144 3 was be VBD cord-005453-4057qib7 4144 4 acute acute JJ cord-005453-4057qib7 4144 5 leukemia leukemia NN cord-005453-4057qib7 4144 6 in in IN cord-005453-4057qib7 4144 7 2 2 CD cord-005453-4057qib7 4144 8 cases case NNS cord-005453-4057qib7 4144 9 ( ( -LRB- cord-005453-4057qib7 4144 10 1 1 CD cord-005453-4057qib7 4144 11 ALL all DT cord-005453-4057qib7 4144 12 and and CC cord-005453-4057qib7 4144 13 1 1 CD cord-005453-4057qib7 4144 14 AML AML NNP cord-005453-4057qib7 4144 15 ) ) -RRB- cord-005453-4057qib7 4144 16 , , , cord-005453-4057qib7 4144 17 severe severe JJ cord-005453-4057qib7 4144 18 aplastic aplastic JJ cord-005453-4057qib7 4144 19 anemia anemia NN cord-005453-4057qib7 4144 20 in in IN cord-005453-4057qib7 4144 21 3 3 CD cord-005453-4057qib7 4144 22 , , , cord-005453-4057qib7 4144 23 and and CC cord-005453-4057qib7 4144 24 primary primary JJ cord-005453-4057qib7 4144 25 immunodeficiency immunodeficiency NN cord-005453-4057qib7 4144 26 in in IN cord-005453-4057qib7 4144 27 1 1 CD cord-005453-4057qib7 4144 28 . . . cord-005453-4057qib7 4145 1 They -PRON- PRP cord-005453-4057qib7 4145 2 received receive VBD cord-005453-4057qib7 4145 3 their -PRON- PRP$ cord-005453-4057qib7 4145 4 first first JJ cord-005453-4057qib7 4145 5 SCT SCT NNP cord-005453-4057qib7 4145 6 in in IN cord-005453-4057qib7 4145 7 all all DT cord-005453-4057qib7 4145 8 cases case NNS cord-005453-4057qib7 4145 9 , , , cord-005453-4057qib7 4145 10 3 3 CD cord-005453-4057qib7 4145 11 from from IN cord-005453-4057qib7 4145 12 MUD mud NN cord-005453-4057qib7 4145 13 and and CC cord-005453-4057qib7 4145 14 3 3 CD cord-005453-4057qib7 4145 15 from from IN cord-005453-4057qib7 4145 16 MMRD MMRD NNP cord-005453-4057qib7 4146 1 ( ( -LRB- cord-005453-4057qib7 4146 2 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 4146 3 depleted deplete VBD cord-005453-4057qib7 4146 4 haploidentical haploidentical JJ cord-005453-4057qib7 4146 5 grafts graft NNS cord-005453-4057qib7 4146 6 ) ) -RRB- cord-005453-4057qib7 4146 7 , , , cord-005453-4057qib7 4146 8 with with IN cord-005453-4057qib7 4146 9 MAC MAC NNP cord-005453-4057qib7 4146 10 regimen regimen NN cord-005453-4057qib7 4146 11 in in IN cord-005453-4057qib7 4146 12 2 2 CD cord-005453-4057qib7 4146 13 cases case NNS cord-005453-4057qib7 4146 14 , , , cord-005453-4057qib7 4146 15 and and CC cord-005453-4057qib7 4146 16 RIC RIC NNP cord-005453-4057qib7 4146 17 in in IN cord-005453-4057qib7 4146 18 4 4 CD cord-005453-4057qib7 4146 19 cases case NNS cord-005453-4057qib7 4146 20 . . . cord-005453-4057qib7 4147 1 3 3 CD cord-005453-4057qib7 4147 2 of of IN cord-005453-4057qib7 4147 3 them -PRON- PRP cord-005453-4057qib7 4147 4 received receive VBD cord-005453-4057qib7 4147 5 calcineurin calcineurin NNP cord-005453-4057qib7 4147 6 inhibitors inhibitor NNS cord-005453-4057qib7 4147 7 ( ( -LRB- cord-005453-4057qib7 4147 8 cyclosporine cyclosporine NN cord-005453-4057qib7 4147 9 ) ) -RRB- cord-005453-4057qib7 4147 10 as as IN cord-005453-4057qib7 4147 11 GVHD GVHD NNP cord-005453-4057qib7 4147 12 prophylaxis prophylaxis NN cord-005453-4057qib7 4147 13 . . . cord-005453-4057qib7 4148 1 All all DT cord-005453-4057qib7 4148 2 patients patient NNS cord-005453-4057qib7 4148 3 developed develop VBD cord-005453-4057qib7 4148 4 aGVHD aGVHD NNP cord-005453-4057qib7 4149 1 ( ( -LRB- cord-005453-4057qib7 4149 2 grade grade NN cord-005453-4057qib7 4149 3 2 2 CD cord-005453-4057qib7 4149 4 or or CC cord-005453-4057qib7 4149 5 higher high JJR cord-005453-4057qib7 4149 6 in in IN cord-005453-4057qib7 4149 7 3 3 CD cord-005453-4057qib7 4149 8 cases case NNS cord-005453-4057qib7 4149 9 ) ) -RRB- cord-005453-4057qib7 4149 10 . . . cord-005453-4057qib7 4150 1 and and CC cord-005453-4057qib7 4150 2 5 5 CD cord-005453-4057qib7 4150 3 patients patient NNS cord-005453-4057qib7 4150 4 presented present VBD cord-005453-4057qib7 4150 5 viral viral JJ cord-005453-4057qib7 4150 6 reactivation reactivation NN cord-005453-4057qib7 4150 7 . . . cord-005453-4057qib7 4151 1 Hypertension hypertension NN cord-005453-4057qib7 4151 2 was be VBD cord-005453-4057qib7 4151 3 present present JJ cord-005453-4057qib7 4151 4 in in IN cord-005453-4057qib7 4151 5 4 4 CD cord-005453-4057qib7 4151 6 cases case NNS cord-005453-4057qib7 4151 7 at at IN cord-005453-4057qib7 4151 8 TMA TMA NNP cord-005453-4057qib7 4151 9 diagnosis diagnosis NN cord-005453-4057qib7 4151 10 , , , cord-005453-4057qib7 4151 11 requiring require VBG cord-005453-4057qib7 4151 12 2 2 CD cord-005453-4057qib7 4151 13 or or CC cord-005453-4057qib7 4151 14 more more JJR cord-005453-4057qib7 4151 15 antihypertensive antihypertensive JJ cord-005453-4057qib7 4151 16 drugs drug NNS cord-005453-4057qib7 4151 17 in in IN cord-005453-4057qib7 4151 18 3 3 CD cord-005453-4057qib7 4151 19 of of IN cord-005453-4057qib7 4151 20 them -PRON- PRP cord-005453-4057qib7 4151 21 . . . cord-005453-4057qib7 4152 1 All all DT cord-005453-4057qib7 4152 2 patients patient NNS cord-005453-4057qib7 4152 3 had have VBD cord-005453-4057qib7 4152 4 renal renal JJ cord-005453-4057qib7 4152 5 injury injury NN cord-005453-4057qib7 4152 6 consisting consist VBG cord-005453-4057qib7 4152 7 of of IN cord-005453-4057qib7 4152 8 less less JJR cord-005453-4057qib7 4152 9 - - HYPH cord-005453-4057qib7 4152 10 than than IN cord-005453-4057qib7 4152 11 - - HYPH cord-005453-4057qib7 4152 12 normal normal JJ cord-005453-4057qib7 4152 13 glomerular glomerular JJ cord-005453-4057qib7 4152 14 filtration filtration NN cord-005453-4057qib7 4152 15 rate rate NN cord-005453-4057qib7 4152 16 ( ( -LRB- cord-005453-4057qib7 4152 17 median median NN cord-005453-4057qib7 4152 18 of of IN cord-005453-4057qib7 4152 19 41 41 CD cord-005453-4057qib7 4152 20 ( ( -LRB- cord-005453-4057qib7 4152 21 20 20 CD cord-005453-4057qib7 4152 22 - - SYM cord-005453-4057qib7 4152 23 59 59 CD cord-005453-4057qib7 4152 24 ) ) -RRB- cord-005453-4057qib7 4152 25 ) ) -RRB- cord-005453-4057qib7 4152 26 and and CC cord-005453-4057qib7 4152 27 proteinuria proteinuria NN cord-005453-4057qib7 4152 28 , , , cord-005453-4057qib7 4152 29 with with IN cord-005453-4057qib7 4152 30 urine urine NN cord-005453-4057qib7 4152 31 protein protein NN cord-005453-4057qib7 4152 32 - - HYPH cord-005453-4057qib7 4152 33 to to IN cord-005453-4057qib7 4152 34 - - HYPH cord-005453-4057qib7 4152 35 creatinine creatinine NN cord-005453-4057qib7 4152 36 ratio ratio NN cord-005453-4057qib7 4152 37 higher high JJR cord-005453-4057qib7 4152 38 tan tan NNP cord-005453-4057qib7 4152 39 2 2 CD cord-005453-4057qib7 4152 40 mg mg NNP cord-005453-4057qib7 4152 41 / / SYM cord-005453-4057qib7 4152 42 mg mg NN cord-005453-4057qib7 4152 43 in in IN cord-005453-4057qib7 4152 44 2 2 CD cord-005453-4057qib7 4152 45 cases case NNS cord-005453-4057qib7 4153 1 ( ( -LRB- cord-005453-4057qib7 4153 2 data datum NNS cord-005453-4057qib7 4153 3 not not RB cord-005453-4057qib7 4153 4 available available JJ cord-005453-4057qib7 4153 5 in in IN cord-005453-4057qib7 4153 6 2 2 CD cord-005453-4057qib7 4153 7 patients patient NNS cord-005453-4057qib7 4153 8 ) ) -RRB- cord-005453-4057qib7 4153 9 . . . cord-005453-4057qib7 4154 1 Serum serum NN cord-005453-4057qib7 4154 2 haptoglobin haptoglobin NN cord-005453-4057qib7 4154 3 was be VBD cord-005453-4057qib7 4154 4 decreased decrease VBN cord-005453-4057qib7 4154 5 in in IN cord-005453-4057qib7 4154 6 just just RB cord-005453-4057qib7 4154 7 2 2 CD cord-005453-4057qib7 4154 8 cases case NNS cord-005453-4057qib7 4154 9 at at IN cord-005453-4057qib7 4154 10 diagnosis diagnosis NN cord-005453-4057qib7 4154 11 , , , cord-005453-4057qib7 4154 12 and and CC cord-005453-4057qib7 4154 13 schistocytes schistocyte NNS cord-005453-4057qib7 4154 14 were be VBD cord-005453-4057qib7 4154 15 detected detect VBN cord-005453-4057qib7 4154 16 in in IN cord-005453-4057qib7 4154 17 3 3 CD cord-005453-4057qib7 4154 18 patients patient NNS cord-005453-4057qib7 4154 19 . . . cord-005453-4057qib7 4155 1 Cutaneos cutaneos JJ cord-005453-4057qib7 4155 2 signs sign NNS cord-005453-4057qib7 4155 3 were be VBD cord-005453-4057qib7 4155 4 present present JJ cord-005453-4057qib7 4155 5 in in IN cord-005453-4057qib7 4155 6 all all DT cord-005453-4057qib7 4155 7 cases case NNS cord-005453-4057qib7 4155 8 , , , cord-005453-4057qib7 4155 9 digestive digestive JJ cord-005453-4057qib7 4155 10 symptoms symptom NNS cord-005453-4057qib7 4155 11 in in IN cord-005453-4057qib7 4155 12 2 2 CD cord-005453-4057qib7 4155 13 , , , cord-005453-4057qib7 4155 14 neurological neurological JJ cord-005453-4057qib7 4155 15 affection affection NN cord-005453-4057qib7 4155 16 in in IN cord-005453-4057qib7 4155 17 2 2 CD cord-005453-4057qib7 4155 18 , , , cord-005453-4057qib7 4155 19 and and CC cord-005453-4057qib7 4155 20 notoriously notoriously RB cord-005453-4057qib7 4155 21 all all DT cord-005453-4057qib7 4155 22 of of IN cord-005453-4057qib7 4155 23 them -PRON- PRP cord-005453-4057qib7 4155 24 developed develop VBD cord-005453-4057qib7 4155 25 polyserositis polyserositis NN cord-005453-4057qib7 4155 26 . . . cord-005453-4057qib7 4156 1 C3 C3 NNP cord-005453-4057qib7 4156 2 and and CC cord-005453-4057qib7 4156 3 C4 C4 NNP cord-005453-4057qib7 4156 4 were be VBD cord-005453-4057qib7 4156 5 normal normal JJ cord-005453-4057qib7 4156 6 in in IN cord-005453-4057qib7 4156 7 all all DT cord-005453-4057qib7 4156 8 cases case NNS cord-005453-4057qib7 4156 9 , , , cord-005453-4057qib7 4156 10 with with IN cord-005453-4057qib7 4156 11 sC5b9 sC5b9 NNS cord-005453-4057qib7 4156 12 higher high JJR cord-005453-4057qib7 4156 13 than than IN cord-005453-4057qib7 4156 14 244 244 CD cord-005453-4057qib7 4156 15 ng ng NN cord-005453-4057qib7 4156 16 / / SYM cord-005453-4057qib7 4156 17 mL ml NN cord-005453-4057qib7 4156 18 in in IN cord-005453-4057qib7 4156 19 2 2 CD cord-005453-4057qib7 4156 20 patients patient NNS cord-005453-4057qib7 4156 21 and and CC cord-005453-4057qib7 4156 22 lower low JJR cord-005453-4057qib7 4156 23 in in IN cord-005453-4057qib7 4156 24 1 1 CD cord-005453-4057qib7 4156 25 ( ( -LRB- cord-005453-4057qib7 4156 26 data datum NNS cord-005453-4057qib7 4156 27 not not RB cord-005453-4057qib7 4156 28 available available JJ cord-005453-4057qib7 4156 29 in in IN cord-005453-4057qib7 4156 30 3 3 CD cord-005453-4057qib7 4156 31 cases case NNS cord-005453-4057qib7 4156 32 ) ) -RRB- cord-005453-4057qib7 4156 33 . . . cord-005453-4057qib7 4157 1 All all DT cord-005453-4057qib7 4157 2 patients patient NNS cord-005453-4057qib7 4157 3 received receive VBD cord-005453-4057qib7 4157 4 defibrotide defibrotide NN cord-005453-4057qib7 4157 5 as as IN cord-005453-4057qib7 4157 6 treatment treatment NN cord-005453-4057qib7 4157 7 , , , cord-005453-4057qib7 4157 8 and and CC cord-005453-4057qib7 4157 9 4 4 CD cord-005453-4057qib7 4157 10 cases case NNS cord-005453-4057qib7 4157 11 received receive VBN cord-005453-4057qib7 4157 12 also also RB cord-005453-4057qib7 4157 13 rituximab rituximab VBN cord-005453-4057qib7 4157 14 , , , cord-005453-4057qib7 4157 15 associated associate VBN cord-005453-4057qib7 4157 16 to to IN cord-005453-4057qib7 4157 17 therapeutical therapeutical JJ cord-005453-4057qib7 4157 18 plasma plasma NN cord-005453-4057qib7 4157 19 exchange exchange NN cord-005453-4057qib7 4157 20 in in IN cord-005453-4057qib7 4157 21 3 3 CD cord-005453-4057qib7 4157 22 . . . cord-005453-4057qib7 4158 1 All all DT cord-005453-4057qib7 4158 2 of of IN cord-005453-4057qib7 4158 3 them -PRON- PRP cord-005453-4057qib7 4158 4 received receive VBD cord-005453-4057qib7 4158 5 Eculizumab Eculizumab NNP cord-005453-4057qib7 4158 6 , , , cord-005453-4057qib7 4158 7 as as IN cord-005453-4057qib7 4158 8 first first JJ cord-005453-4057qib7 4158 9 line line NN cord-005453-4057qib7 4158 10 in in IN cord-005453-4057qib7 4158 11 2 2 CD cord-005453-4057qib7 4158 12 cases case NNS cord-005453-4057qib7 4158 13 ( ( -LRB- cord-005453-4057qib7 4158 14 median median NN cord-005453-4057qib7 4158 15 of of IN cord-005453-4057qib7 4158 16 40 40 CD cord-005453-4057qib7 4158 17 days day NNS cord-005453-4057qib7 4158 18 between between IN cord-005453-4057qib7 4158 19 diagnosis diagnosis NN cord-005453-4057qib7 4158 20 and and CC cord-005453-4057qib7 4158 21 Eculizumab Eculizumab NNP cord-005453-4057qib7 4158 22 start start VBP cord-005453-4057qib7 4158 23 ) ) -RRB- cord-005453-4057qib7 4158 24 . . . cord-005453-4057qib7 4159 1 Treatment treatment NN cord-005453-4057qib7 4159 2 was be VBD cord-005453-4057qib7 4159 3 correctly correctly RB cord-005453-4057qib7 4159 4 monitorized monitorize VBN cord-005453-4057qib7 4159 5 with with IN cord-005453-4057qib7 4159 6 CH50 CH50 NNP cord-005453-4057qib7 4159 7 levels level NNS cord-005453-4057qib7 4159 8 in in IN cord-005453-4057qib7 4159 9 3 3 CD cord-005453-4057qib7 4159 10 cases case NNS cord-005453-4057qib7 4159 11 ( ( -LRB- cord-005453-4057qib7 4159 12 not not RB cord-005453-4057qib7 4159 13 available available JJ cord-005453-4057qib7 4159 14 quick quick JJ cord-005453-4057qib7 4159 15 enough enough RB cord-005453-4057qib7 4159 16 in in IN cord-005453-4057qib7 4159 17 other other JJ cord-005453-4057qib7 4159 18 3 3 CD cord-005453-4057qib7 4159 19 ) ) -RRB- cord-005453-4057qib7 4159 20 . . . cord-005453-4057qib7 4160 1 Median median JJ cord-005453-4057qib7 4160 2 number number NN cord-005453-4057qib7 4160 3 of of IN cord-005453-4057qib7 4160 4 doses dose NNS cord-005453-4057qib7 4160 5 needed need VBN cord-005453-4057qib7 4160 6 in in IN cord-005453-4057qib7 4160 7 induction induction NN cord-005453-4057qib7 4160 8 therapy therapy NN cord-005453-4057qib7 4160 9 was be VBD cord-005453-4057qib7 4160 10 8 8 CD cord-005453-4057qib7 4160 11 , , , cord-005453-4057qib7 4160 12 and and CC cord-005453-4057qib7 4160 13 median median JJ cord-005453-4057qib7 4160 14 interval interval NN cord-005453-4057qib7 4160 15 between between IN cord-005453-4057qib7 4160 16 doses dose NNS cord-005453-4057qib7 4160 17 was be VBD cord-005453-4057qib7 4160 18 7 7 CD cord-005453-4057qib7 4160 19 days day NNS cord-005453-4057qib7 4160 20 . . . cord-005453-4057qib7 4161 1 2 2 CD cord-005453-4057qib7 4161 2 patients patient NNS cord-005453-4057qib7 4161 3 required require VBN cord-005453-4057qib7 4161 4 reduced reduced JJ cord-005453-4057qib7 4161 5 interval interval NN cord-005453-4057qib7 4161 6 and and CC cord-005453-4057qib7 4161 7 higher high JJR cord-005453-4057qib7 4161 8 doses dose NNS cord-005453-4057qib7 4161 9 to to TO cord-005453-4057qib7 4161 10 maintain maintain VB cord-005453-4057qib7 4161 11 CH50 CH50 NNP cord-005453-4057qib7 4161 12 supressed supresse VBN cord-005453-4057qib7 4161 13 . . . cord-005453-4057qib7 4162 1 2 2 CD cord-005453-4057qib7 4162 2 patients patient NNS cord-005453-4057qib7 4162 3 did do VBD cord-005453-4057qib7 4162 4 not not RB cord-005453-4057qib7 4162 5 respond respond VB cord-005453-4057qib7 4162 6 , , , cord-005453-4057qib7 4162 7 and and CC cord-005453-4057qib7 4162 8 died die VBD cord-005453-4057qib7 4162 9 because because IN cord-005453-4057qib7 4162 10 of of IN cord-005453-4057qib7 4162 11 TMA TMA NNP cord-005453-4057qib7 4162 12 . . . cord-005453-4057qib7 4163 1 4 4 CD cord-005453-4057qib7 4163 2 patients patient NNS cord-005453-4057qib7 4163 3 had have VBD cord-005453-4057qib7 4163 4 hematological hematological JJ cord-005453-4057qib7 4163 5 response response NN cord-005453-4057qib7 4163 6 , , , cord-005453-4057qib7 4163 7 with with IN cord-005453-4057qib7 4163 8 chronic chronic JJ cord-005453-4057qib7 4163 9 renal renal JJ cord-005453-4057qib7 4163 10 injury injury NN cord-005453-4057qib7 4163 11 in in IN cord-005453-4057qib7 4163 12 3 3 CD cord-005453-4057qib7 4163 13 of of IN cord-005453-4057qib7 4163 14 them -PRON- PRP cord-005453-4057qib7 4163 15 and and CC cord-005453-4057qib7 4163 16 resolution resolution NN cord-005453-4057qib7 4163 17 of of IN cord-005453-4057qib7 4163 18 acute acute JJ cord-005453-4057qib7 4163 19 renal renal JJ cord-005453-4057qib7 4163 20 failure failure NN cord-005453-4057qib7 4163 21 in in IN cord-005453-4057qib7 4163 22 1 1 CD cord-005453-4057qib7 4163 23 case case NN cord-005453-4057qib7 4163 24 . . . cord-005453-4057qib7 4164 1 Nevertheless nevertheless RB cord-005453-4057qib7 4164 2 1 1 CD cord-005453-4057qib7 4164 3 patient patient NN cord-005453-4057qib7 4164 4 responding respond VBG cord-005453-4057qib7 4164 5 to to IN cord-005453-4057qib7 4164 6 Eculizumab Eculizumab NNP cord-005453-4057qib7 4164 7 died die VBD cord-005453-4057qib7 4164 8 because because IN cord-005453-4057qib7 4164 9 of of IN cord-005453-4057qib7 4164 10 TMA TMA NNP cord-005453-4057qib7 4164 11 related relate VBN cord-005453-4057qib7 4164 12 complications complication NNS cord-005453-4057qib7 4164 13 , , , cord-005453-4057qib7 4164 14 and and CC cord-005453-4057qib7 4164 15 1 1 CD cord-005453-4057qib7 4164 16 because because IN cord-005453-4057qib7 4164 17 of of IN cord-005453-4057qib7 4164 18 an an DT cord-005453-4057qib7 4164 19 invasive invasive JJ cord-005453-4057qib7 4164 20 fungal fungal NN cord-005453-4057qib7 4164 21 infection infection NN cord-005453-4057qib7 4164 22 . . . cord-005453-4057qib7 4165 1 2 2 CD cord-005453-4057qib7 4165 2 patients patient NNS cord-005453-4057qib7 4165 3 are be VBP cord-005453-4057qib7 4165 4 alive alive JJ cord-005453-4057qib7 4165 5 , , , cord-005453-4057qib7 4165 6 with with IN cord-005453-4057qib7 4165 7 a a DT cord-005453-4057qib7 4165 8 median median NN cord-005453-4057qib7 4165 9 follow follow NN cord-005453-4057qib7 4165 10 up up IN cord-005453-4057qib7 4165 11 of of IN cord-005453-4057qib7 4165 12 6 6 CD cord-005453-4057qib7 4165 13 months month NNS cord-005453-4057qib7 4165 14 from from IN cord-005453-4057qib7 4165 15 treatment treatment NN cord-005453-4057qib7 4165 16 start start NN cord-005453-4057qib7 4165 17 . . . cord-005453-4057qib7 4166 1 Conclusions conclusion NNS cord-005453-4057qib7 4166 2 : : : cord-005453-4057qib7 4167 1 Our -PRON- PRP$ cord-005453-4057qib7 4167 2 experience experience NN cord-005453-4057qib7 4167 3 supports support VBZ cord-005453-4057qib7 4167 4 promising promising JJ cord-005453-4057qib7 4167 5 results result NNS cord-005453-4057qib7 4167 6 of of IN cord-005453-4057qib7 4167 7 Eculizumab Eculizumab NNP cord-005453-4057qib7 4167 8 based base VBN cord-005453-4057qib7 4167 9 treatment treatment NN cord-005453-4057qib7 4167 10 for for IN cord-005453-4057qib7 4167 11 TA TA NNP cord-005453-4057qib7 4167 12 - - HYPH cord-005453-4057qib7 4167 13 TMA TMA NNP cord-005453-4057qib7 4167 14 , , , cord-005453-4057qib7 4167 15 highlighting highlight VBG cord-005453-4057qib7 4167 16 the the DT cord-005453-4057qib7 4167 17 importance importance NN cord-005453-4057qib7 4167 18 of of IN cord-005453-4057qib7 4167 19 an an DT cord-005453-4057qib7 4167 20 early early JJ cord-005453-4057qib7 4167 21 treatment treatment NN cord-005453-4057qib7 4167 22 and and CC cord-005453-4057qib7 4167 23 a a DT cord-005453-4057qib7 4167 24 careful careful JJ cord-005453-4057qib7 4167 25 therapy therapy NN cord-005453-4057qib7 4167 26 monitoring monitoring NN cord-005453-4057qib7 4167 27 by by IN cord-005453-4057qib7 4167 28 CH50 CH50 NNP cord-005453-4057qib7 4167 29 supression supression NN cord-005453-4057qib7 4167 30 . . . cord-005453-4057qib7 4168 1 Prospective prospective JJ cord-005453-4057qib7 4168 2 studies study NNS cord-005453-4057qib7 4168 3 are be VBP cord-005453-4057qib7 4168 4 needed need VBN cord-005453-4057qib7 4168 5 to to TO cord-005453-4057qib7 4168 6 achieve achieve VB cord-005453-4057qib7 4168 7 a a DT cord-005453-4057qib7 4168 8 better well JJR cord-005453-4057qib7 4168 9 knowledge knowledge NN cord-005453-4057qib7 4168 10 of of IN cord-005453-4057qib7 4168 11 this this DT cord-005453-4057qib7 4168 12 pathology pathology NN cord-005453-4057qib7 4168 13 and and CC cord-005453-4057qib7 4168 14 its -PRON- PRP$ cord-005453-4057qib7 4168 15 treatment treatment NN cord-005453-4057qib7 4168 16 . . . cord-005453-4057qib7 4169 1 Disclosure disclosure NN cord-005453-4057qib7 4169 2 : : : cord-005453-4057qib7 4169 3 Nothing nothing NN cord-005453-4057qib7 4169 4 to to TO cord-005453-4057qib7 4169 5 declare declare VB cord-005453-4057qib7 4169 6 Background background NN cord-005453-4057qib7 4169 7 : : : cord-005453-4057qib7 4170 1 Approximately approximately RB cord-005453-4057qib7 4170 2 40 40 CD cord-005453-4057qib7 4170 3 - - SYM cord-005453-4057qib7 4170 4 50 50 CD cord-005453-4057qib7 4170 5 % % NN cord-005453-4057qib7 4170 6 of of IN cord-005453-4057qib7 4170 7 Allogeneic Allogeneic NNP cord-005453-4057qib7 4170 8 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 4170 9 Stem Stem NNP cord-005453-4057qib7 4170 10 Cell cell NN cord-005453-4057qib7 4170 11 Transplant transplant NN cord-005453-4057qib7 4170 12 ( ( -LRB- cord-005453-4057qib7 4170 13 Allo Allo NNP cord-005453-4057qib7 4170 14 - - HYPH cord-005453-4057qib7 4170 15 HSCT HSCT NNP cord-005453-4057qib7 4170 16 ) ) -RRB- cord-005453-4057qib7 4170 17 are be VBP cord-005453-4057qib7 4170 18 made make VBN cord-005453-4057qib7 4170 19 with with IN cord-005453-4057qib7 4170 20 some some DT cord-005453-4057qib7 4170 21 sort sort NN cord-005453-4057qib7 4170 22 of of IN cord-005453-4057qib7 4170 23 ABO ABO NNP cord-005453-4057qib7 4170 24 blood blood NN cord-005453-4057qib7 4170 25 group group NN cord-005453-4057qib7 4170 26 system system NN cord-005453-4057qib7 4170 27 incompatibility incompatibility NN cord-005453-4057qib7 4170 28 . . . cord-005453-4057qib7 4171 1 An an DT cord-005453-4057qib7 4171 2 HSCT HSCT NNP cord-005453-4057qib7 4171 3 ABO ABO NNP cord-005453-4057qib7 4171 4 donor donor NN cord-005453-4057qib7 4171 5 - - HYPH cord-005453-4057qib7 4171 6 recipient recipient NN cord-005453-4057qib7 4171 7 incompatibility incompatibility NN cord-005453-4057qib7 4171 8 implies imply VBZ cord-005453-4057qib7 4171 9 risks risk NNS cord-005453-4057qib7 4171 10 of of IN cord-005453-4057qib7 4171 11 complications complication NNS cord-005453-4057qib7 4171 12 during during IN cord-005453-4057qib7 4171 13 the the DT cord-005453-4057qib7 4171 14 process process NN cord-005453-4057qib7 4171 15 of of IN cord-005453-4057qib7 4171 16 infusion infusion NN cord-005453-4057qib7 4171 17 as as IN cord-005453-4057qib7 4171 18 acute acute JJ cord-005453-4057qib7 4171 19 hemolytic hemolytic JJ cord-005453-4057qib7 4171 20 anemia anemia NN cord-005453-4057qib7 4171 21 ( ( -LRB- cord-005453-4057qib7 4171 22 AH AH NNP cord-005453-4057qib7 4171 23 ) ) -RRB- cord-005453-4057qib7 4171 24 , , , cord-005453-4057qib7 4171 25 delayed delay VBN cord-005453-4057qib7 4171 26 graft graft NN cord-005453-4057qib7 4171 27 and and CC cord-005453-4057qib7 4171 28 other other JJ cord-005453-4057qib7 4171 29 later later JJ cord-005453-4057qib7 4171 30 complications complication NNS cord-005453-4057qib7 4171 31 due due IN cord-005453-4057qib7 4171 32 to to IN cord-005453-4057qib7 4171 33 the the DT cord-005453-4057qib7 4171 34 presence presence NN cord-005453-4057qib7 4171 35 of of IN cord-005453-4057qib7 4171 36 isohemaglutinins isohemaglutinins NNP cord-005453-4057qib7 4172 1 ( ( -LRB- cord-005453-4057qib7 4172 2 Pure Pure NNP cord-005453-4057qib7 4172 3 Red Red NNP cord-005453-4057qib7 4172 4 Cell Cell NNP cord-005453-4057qib7 4172 5 Aplasia Aplasia NNP cord-005453-4057qib7 4172 6 or or CC cord-005453-4057qib7 4172 7 passenger passenger NN cord-005453-4057qib7 4172 8 lymphocyte lymphocyte NN cord-005453-4057qib7 4172 9 syndrome syndrome NN cord-005453-4057qib7 4172 10 ) ) -RRB- cord-005453-4057qib7 4172 11 . . . cord-005453-4057qib7 4173 1 Also also RB cord-005453-4057qib7 4173 2 , , , cord-005453-4057qib7 4173 3 ABO ABO NNP cord-005453-4057qib7 4173 4 incompatibility incompatibility NN cord-005453-4057qib7 4173 5 could could MD cord-005453-4057qib7 4173 6 impact impact VB cord-005453-4057qib7 4173 7 on on IN cord-005453-4057qib7 4173 8 graft graft NN cord-005453-4057qib7 4173 9 versus versus IN cord-005453-4057qib7 4173 10 host host NN cord-005453-4057qib7 4173 11 disease disease NN cord-005453-4057qib7 4173 12 ( ( -LRB- cord-005453-4057qib7 4173 13 GVHD GVHD NNP cord-005453-4057qib7 4173 14 ) ) -RRB- cord-005453-4057qib7 4173 15 incidence incidence NN cord-005453-4057qib7 4173 16 , , , cord-005453-4057qib7 4173 17 and and CC cord-005453-4057qib7 4173 18 could could MD cord-005453-4057qib7 4173 19 be be VB cord-005453-4057qib7 4173 20 associated associate VBN cord-005453-4057qib7 4173 21 with with IN cord-005453-4057qib7 4173 22 Not not RB cord-005453-4057qib7 4173 23 Relapse Relapse NNP cord-005453-4057qib7 4173 24 Mortality mortality NN cord-005453-4057qib7 4173 25 ( ( -LRB- cord-005453-4057qib7 4173 26 NRM NRM NNP cord-005453-4057qib7 4173 27 ) ) -RRB- cord-005453-4057qib7 4173 28 and and CC cord-005453-4057qib7 4173 29 overall overall JJ cord-005453-4057qib7 4173 30 survival survival NN cord-005453-4057qib7 4173 31 ( ( -LRB- cord-005453-4057qib7 4173 32 OS OS NNP cord-005453-4057qib7 4173 33 ) ) -RRB- cord-005453-4057qib7 4173 34 . . . cord-005453-4057qib7 4174 1 There there EX cord-005453-4057qib7 4174 2 are be VBP cord-005453-4057qib7 4174 3 not not RB cord-005453-4057qib7 4174 4 concluded conclude VBN cord-005453-4057qib7 4174 5 evidence evidence NN cord-005453-4057qib7 4174 6 about about IN cord-005453-4057qib7 4174 7 the the DT cord-005453-4057qib7 4174 8 ABO ABO NNP cord-005453-4057qib7 4174 9 incompatibility incompatibility NN cord-005453-4057qib7 4174 10 impact impact NN cord-005453-4057qib7 4174 11 , , , cord-005453-4057qib7 4174 12 so so CC cord-005453-4057qib7 4174 13 the the DT cord-005453-4057qib7 4174 14 aim aim NN cord-005453-4057qib7 4174 15 of of IN cord-005453-4057qib7 4174 16 this this DT cord-005453-4057qib7 4174 17 study study NN cord-005453-4057qib7 4174 18 was be VBD cord-005453-4057qib7 4174 19 to to TO cord-005453-4057qib7 4174 20 identify identify VB cord-005453-4057qib7 4174 21 complications complication NNS cord-005453-4057qib7 4174 22 and and CC cord-005453-4057qib7 4174 23 response response NN cord-005453-4057qib7 4174 24 associated associate VBN cord-005453-4057qib7 4174 25 with with IN cord-005453-4057qib7 4174 26 ABO ABO NNP cord-005453-4057qib7 4174 27 incompatibility incompatibility NN cord-005453-4057qib7 4174 28 in in IN cord-005453-4057qib7 4174 29 patients patient NNS cord-005453-4057qib7 4174 30 undergoing undergo VBG cord-005453-4057qib7 4174 31 Allogeneic Allogeneic NNP cord-005453-4057qib7 4174 32 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 4174 33 Stem Stem NNP cord-005453-4057qib7 4174 34 Cell Cell NNP cord-005453-4057qib7 4174 35 Transplantation transplantation NN cord-005453-4057qib7 4174 36 . . . cord-005453-4057qib7 4175 1 Methods method NNS cord-005453-4057qib7 4175 2 : : : cord-005453-4057qib7 4175 3 A a DT cord-005453-4057qib7 4175 4 retrospective retrospective JJ cord-005453-4057qib7 4175 5 study study NN cord-005453-4057qib7 4175 6 was be VBD cord-005453-4057qib7 4175 7 performed perform VBN cord-005453-4057qib7 4175 8 on on IN cord-005453-4057qib7 4175 9 patients patient NNS cord-005453-4057qib7 4175 10 who who WP cord-005453-4057qib7 4175 11 receive receive VBP cord-005453-4057qib7 4175 12 an an DT cord-005453-4057qib7 4175 13 allo allo NN cord-005453-4057qib7 4175 14 - - HYPH cord-005453-4057qib7 4175 15 HSCT HSCT NNP cord-005453-4057qib7 4175 16 between between IN cord-005453-4057qib7 4175 17 January January NNP cord-005453-4057qib7 4175 18 2014 2014 CD cord-005453-4057qib7 4175 19 and and CC cord-005453-4057qib7 4175 20 August August NNP cord-005453-4057qib7 4175 21 2018 2018 CD cord-005453-4057qib7 4175 22 . . . cord-005453-4057qib7 4176 1 Two two CD cord-005453-4057qib7 4176 2 groups group NNS cord-005453-4057qib7 4176 3 were be VBD cord-005453-4057qib7 4176 4 performed perform VBN cord-005453-4057qib7 4176 5 according accord VBG cord-005453-4057qib7 4176 6 to to IN cord-005453-4057qib7 4176 7 the the DT cord-005453-4057qib7 4176 8 presences presence NNS cord-005453-4057qib7 4176 9 or or CC cord-005453-4057qib7 4176 10 not not RB cord-005453-4057qib7 4176 11 of of IN cord-005453-4057qib7 4176 12 ABO ABO NNP cord-005453-4057qib7 4176 13 incompatibility incompatibility NN cord-005453-4057qib7 4176 14 . . . cord-005453-4057qib7 4177 1 Demographic demographic JJ cord-005453-4057qib7 4177 2 and and CC cord-005453-4057qib7 4177 3 clinical clinical JJ cord-005453-4057qib7 4177 4 information information NN cord-005453-4057qib7 4177 5 was be VBD cord-005453-4057qib7 4177 6 collected collect VBN cord-005453-4057qib7 4177 7 from from IN cord-005453-4057qib7 4177 8 physical physical JJ cord-005453-4057qib7 4177 9 and and CC cord-005453-4057qib7 4177 10 electronic electronic JJ cord-005453-4057qib7 4177 11 medical medical JJ cord-005453-4057qib7 4177 12 records record NNS cord-005453-4057qib7 4177 13 , , , cord-005453-4057qib7 4177 14 and and CC cord-005453-4057qib7 4177 15 information information NN cord-005453-4057qib7 4177 16 was be VBD cord-005453-4057qib7 4177 17 analyzed analyze VBN cord-005453-4057qib7 4177 18 in in IN cord-005453-4057qib7 4177 19 SPSS SPSS NNP cord-005453-4057qib7 4177 20 v21 v21 NNP cord-005453-4057qib7 4177 21 Results Results NNPS cord-005453-4057qib7 4177 22 : : : cord-005453-4057qib7 4177 23 Sixty sixty CD cord-005453-4057qib7 4177 24 - - HYPH cord-005453-4057qib7 4177 25 eight eight CD cord-005453-4057qib7 4177 26 patients patient NNS cord-005453-4057qib7 4177 27 were be VBD cord-005453-4057qib7 4177 28 enrolled enrol VBN cord-005453-4057qib7 4177 29 in in IN cord-005453-4057qib7 4177 30 the the DT cord-005453-4057qib7 4177 31 study study NN cord-005453-4057qib7 4177 32 , , , cord-005453-4057qib7 4177 33 54 54 CD cord-005453-4057qib7 4177 34 % % NN cord-005453-4057qib7 4177 35 male male NN cord-005453-4057qib7 4177 36 , , , cord-005453-4057qib7 4177 37 the the DT cord-005453-4057qib7 4177 38 median median JJ cord-005453-4057qib7 4177 39 age age NN cord-005453-4057qib7 4177 40 was be VBD cord-005453-4057qib7 4177 41 34 34 CD cord-005453-4057qib7 4177 42 years year NNS cord-005453-4057qib7 4177 43 ( ( -LRB- cord-005453-4057qib7 4177 44 19 19 CD cord-005453-4057qib7 4177 45 - - SYM cord-005453-4057qib7 4177 46 61 61 CD cord-005453-4057qib7 4177 47 ) ) -RRB- cord-005453-4057qib7 4177 48 with with IN cord-005453-4057qib7 4177 49 the the DT cord-005453-4057qib7 4177 50 following follow VBG cord-005453-4057qib7 4177 51 diagnoses diagnosis NNS cord-005453-4057qib7 4178 1 : : : cord-005453-4057qib7 4178 2 acute acute JJ cord-005453-4057qib7 4178 3 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 4178 4 leukemia leukemia NN cord-005453-4057qib7 4178 5 44 44 CD cord-005453-4057qib7 4178 6 % % NN cord-005453-4057qib7 4178 7 , , , cord-005453-4057qib7 4178 8 acute acute JJ cord-005453-4057qib7 4178 9 myeloblastic myeloblastic JJ cord-005453-4057qib7 4178 10 leukemia leukemia NN cord-005453-4057qib7 4178 11 26.5 26.5 CD cord-005453-4057qib7 4178 12 % % NN cord-005453-4057qib7 4178 13 , , , cord-005453-4057qib7 4178 14 granulocytic granulocytic JJ cord-005453-4057qib7 4178 15 chronic chronic JJ cord-005453-4057qib7 4178 16 leukemia leukemia NN cord-005453-4057qib7 4178 17 17.6 17.6 CD cord-005453-4057qib7 4178 18 % % NN cord-005453-4057qib7 4178 19 , , , cord-005453-4057qib7 4178 20 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 4178 21 syndrome syndrome NN cord-005453-4057qib7 4178 22 4.4 4.4 CD cord-005453-4057qib7 4178 23 % % NN cord-005453-4057qib7 4178 24 , , , cord-005453-4057qib7 4178 25 dendritic dendritic JJ cord-005453-4057qib7 4178 26 cell cell NN cord-005453-4057qib7 4178 27 neoplasm neoplasm NN cord-005453-4057qib7 4178 28 4.4 4.4 CD cord-005453-4057qib7 4178 29 % % NN cord-005453-4057qib7 4178 30 , , , cord-005453-4057qib7 4178 31 aplastic aplastic JJ cord-005453-4057qib7 4178 32 anemia anemia NN cord-005453-4057qib7 4178 33 2.9 2.9 CD cord-005453-4057qib7 4178 34 % % NN cord-005453-4057qib7 4178 35 . . . cord-005453-4057qib7 4179 1 Ninety ninety CD cord-005453-4057qib7 4179 2 - - HYPH cord-005453-4057qib7 4179 3 one one CD cord-005453-4057qib7 4179 4 percent percent NN cord-005453-4057qib7 4179 5 of of IN cord-005453-4057qib7 4179 6 the the DT cord-005453-4057qib7 4179 7 patients patient NNS cord-005453-4057qib7 4179 8 received receive VBD cord-005453-4057qib7 4179 9 a a DT cord-005453-4057qib7 4179 10 transplant transplant NN cord-005453-4057qib7 4179 11 from from IN cord-005453-4057qib7 4179 12 an an DT cord-005453-4057qib7 4179 13 identical identical JJ cord-005453-4057qib7 4179 14 HLA HLA NNP cord-005453-4057qib7 4179 15 donor donor NN cord-005453-4057qib7 4179 16 and and CC cord-005453-4057qib7 4179 17 8.8 8.8 CD cord-005453-4057qib7 4179 18 % % NN cord-005453-4057qib7 4179 19 received receive VBD cord-005453-4057qib7 4179 20 a a DT cord-005453-4057qib7 4179 21 haploidentical haploidentical JJ cord-005453-4057qib7 4179 22 transplant transplant NN cord-005453-4057qib7 4179 23 . . . cord-005453-4057qib7 4180 1 Fifty fifty CD cord-005453-4057qib7 4180 2 - - HYPH cord-005453-4057qib7 4180 3 two two CD cord-005453-4057qib7 4180 4 patients patient NNS cord-005453-4057qib7 4180 5 ( ( -LRB- cord-005453-4057qib7 4180 6 76 76 CD cord-005453-4057qib7 4180 7 % % NN cord-005453-4057qib7 4180 8 ) ) -RRB- cord-005453-4057qib7 4180 9 were be VBD cord-005453-4057qib7 4180 10 ABOcompatibility ABOcompatibility NNP cord-005453-4057qib7 4180 11 ( ( -LRB- cord-005453-4057qib7 4180 12 G1 G1 NNP cord-005453-4057qib7 4180 13 ) ) -RRB- cord-005453-4057qib7 4180 14 and and CC cord-005453-4057qib7 4180 15 16 16 CD cord-005453-4057qib7 4180 16 patients patient NNS cord-005453-4057qib7 4180 17 ( ( -LRB- cord-005453-4057qib7 4180 18 24 24 CD cord-005453-4057qib7 4180 19 % % NN cord-005453-4057qib7 4180 20 ) ) -RRB- cord-005453-4057qib7 4180 21 had have VBD cord-005453-4057qib7 4180 22 ABOincompatibility aboincompatibility NN cord-005453-4057qib7 4180 23 ( ( -LRB- cord-005453-4057qib7 4180 24 G2 G2 NNP cord-005453-4057qib7 4180 25 ) ) -RRB- cord-005453-4057qib7 4180 26 . . . cord-005453-4057qib7 4181 1 None none NN cord-005453-4057qib7 4181 2 patient patient JJ cord-005453-4057qib7 4181 3 with with IN cord-005453-4057qib7 4181 4 ABOincompatibility aboincompatibility NN cord-005453-4057qib7 4181 5 received receive VBD cord-005453-4057qib7 4181 6 a a DT cord-005453-4057qib7 4181 7 haploidentical haploidentical JJ cord-005453-4057qib7 4181 8 transplant transplant NN cord-005453-4057qib7 4181 9 . . . cord-005453-4057qib7 4182 1 The the DT cord-005453-4057qib7 4182 2 contrast contrast NN cord-005453-4057qib7 4182 3 between between IN cord-005453-4057qib7 4182 4 groups group NNS cord-005453-4057qib7 4182 5 did do VBD cord-005453-4057qib7 4182 6 n't not RB cord-005453-4057qib7 4182 7 show show VB cord-005453-4057qib7 4182 8 differences difference NNS cord-005453-4057qib7 4182 9 in in IN cord-005453-4057qib7 4182 10 fever fever NN cord-005453-4057qib7 4182 11 , , , cord-005453-4057qib7 4182 12 infections infection NNS cord-005453-4057qib7 4182 13 , , , cord-005453-4057qib7 4182 14 bacterial bacterial JJ cord-005453-4057qib7 4182 15 isolation isolation NN cord-005453-4057qib7 4182 16 , , , cord-005453-4057qib7 4182 17 presence presence NN cord-005453-4057qib7 4182 18 and and CC cord-005453-4057qib7 4182 19 degree degree NN cord-005453-4057qib7 4182 20 of of IN cord-005453-4057qib7 4182 21 acute acute JJ cord-005453-4057qib7 4182 22 or or CC cord-005453-4057qib7 4182 23 chronic chronic JJ cord-005453-4057qib7 4182 24 GVHD GVHD NNP cord-005453-4057qib7 4182 25 and and CC cord-005453-4057qib7 4182 26 relapse relapse NN cord-005453-4057qib7 4182 27 of of IN cord-005453-4057qib7 4182 28 the the DT cord-005453-4057qib7 4182 29 disease disease NN cord-005453-4057qib7 4182 30 . . . cord-005453-4057qib7 4183 1 Graft graft NN cord-005453-4057qib7 4183 2 failure failure NN cord-005453-4057qib7 4183 3 was be VBD cord-005453-4057qib7 4183 4 6%(G1 6%(G1 NNP cord-005453-4057qib7 4183 5 ) ) -RRB- cord-005453-4057qib7 4183 6 vs vs IN cord-005453-4057qib7 4183 7 20%(G2 20%(g2 CD cord-005453-4057qib7 4183 8 ) ) -RRB- cord-005453-4057qib7 4184 1 ( ( -LRB- cord-005453-4057qib7 4184 2 p=0.27 p=0.27 NNP cord-005453-4057qib7 4184 3 ) ) -RRB- cord-005453-4057qib7 4184 4 , , , cord-005453-4057qib7 4184 5 intermediate intermediate JJ cord-005453-4057qib7 4184 6 risk risk NN cord-005453-4057qib7 4184 7 CMV CMV NNP cord-005453-4057qib7 4184 8 serostatus serostatus NN cord-005453-4057qib7 4184 9 79%(G1 79%(g1 CD cord-005453-4057qib7 4184 10 ) ) -RRB- cord-005453-4057qib7 4184 11 vs vs IN cord-005453-4057qib7 4184 12 87(G2 87(g2 CD cord-005453-4057qib7 4184 13 ) ) -RRB- cord-005453-4057qib7 4185 1 ( ( -LRB- cord-005453-4057qib7 4185 2 p=0.35 p=0.35 NNP cord-005453-4057qib7 4185 3 ) ) -RRB- cord-005453-4057qib7 4185 4 . . . cord-005453-4057qib7 4186 1 The the DT cord-005453-4057qib7 4186 2 most most RBS cord-005453-4057qib7 4186 3 relevant relevant JJ cord-005453-4057qib7 4186 4 characteristics characteristic NNS cord-005453-4057qib7 4186 5 and and CC cord-005453-4057qib7 4186 6 complications complication NNS cord-005453-4057qib7 4186 7 are be VBP cord-005453-4057qib7 4186 8 described describe VBN cord-005453-4057qib7 4186 9 in in IN cord-005453-4057qib7 4186 10 table table NN cord-005453-4057qib7 4186 11 1 1 CD cord-005453-4057qib7 4186 12 . . . cord-005453-4057qib7 4187 1 Contrast contrast NN cord-005453-4057qib7 4187 2 analysis analysis NN cord-005453-4057qib7 4187 3 between between IN cord-005453-4057qib7 4187 4 G1 G1 NNP cord-005453-4057qib7 4187 5 vs vs IN cord-005453-4057qib7 4187 6 G2 G2 NNP cord-005453-4057qib7 4187 7 showed show VBD cord-005453-4057qib7 4187 8 that that IN cord-005453-4057qib7 4187 9 within within IN cord-005453-4057qib7 4187 10 the the DT cord-005453-4057qib7 4187 11 whole whole JJ cord-005453-4057qib7 4187 12 group group NN cord-005453-4057qib7 4187 13 there there EX cord-005453-4057qib7 4187 14 were be VBD cord-005453-4057qib7 4187 15 29 29 CD cord-005453-4057qib7 4187 16 deaths death NNS cord-005453-4057qib7 4187 17 ( ( -LRB- cord-005453-4057qib7 4187 18 40 40 CD cord-005453-4057qib7 4187 19 % % NN cord-005453-4057qib7 4187 20 vs vs IN cord-005453-4057qib7 4187 21 50 50 CD cord-005453-4057qib7 4187 22 % % NN cord-005453-4057qib7 4187 23 respectively respectively RB cord-005453-4057qib7 4187 24 ) ) -RRB- cord-005453-4057qib7 4187 25 ( ( -LRB- cord-005453-4057qib7 4187 26 p=0.69 p=0.69 NNP cord-005453-4057qib7 4187 27 ) ) -RRB- cord-005453-4057qib7 4187 28 , , , cord-005453-4057qib7 4187 29 the the DT cord-005453-4057qib7 4187 30 overall overall JJ cord-005453-4057qib7 4187 31 survival survival NN cord-005453-4057qib7 4187 32 1-year 1-year CD cord-005453-4057qib7 4187 33 was be VBD cord-005453-4057qib7 4187 34 74 74 CD cord-005453-4057qib7 4187 35 % % NN cord-005453-4057qib7 4187 36 vs vs IN cord-005453-4057qib7 4187 37 66 66 CD cord-005453-4057qib7 4187 38 % % NN cord-005453-4057qib7 4188 1 ( ( -LRB- cord-005453-4057qib7 4188 2 p=0.58 p=0.58 JJ cord-005453-4057qib7 4188 3 ) ) -RRB- cord-005453-4057qib7 4188 4 with with IN cord-005453-4057qib7 4188 5 a a DT cord-005453-4057qib7 4188 6 median median NN cord-005453-4057qib7 4188 7 of of IN cord-005453-4057qib7 4188 8 29 29 CD cord-005453-4057qib7 4188 9 vs vs IN cord-005453-4057qib7 4188 10 34 34 CD cord-005453-4057qib7 4188 11 months month NNS cord-005453-4057qib7 4188 12 respectively respectively RB cord-005453-4057qib7 4188 13 ; ; : cord-005453-4057qib7 4188 14 mortality mortality NN cord-005453-4057qib7 4188 15 associated associate VBN cord-005453-4057qib7 4188 16 with with IN cord-005453-4057qib7 4188 17 relapse relapse NN cord-005453-4057qib7 4188 18 was be VBD cord-005453-4057qib7 4188 19 68 68 CD cord-005453-4057qib7 4188 20 % % NN cord-005453-4057qib7 4188 21 vs vs IN cord-005453-4057qib7 4188 22 87 87 CD cord-005453-4057qib7 4188 23 % % NN cord-005453-4057qib7 4188 24 respectively respectively RB cord-005453-4057qib7 4188 25 , , , cord-005453-4057qib7 4188 26 and and CC cord-005453-4057qib7 4188 27 mortality mortality NN cord-005453-4057qib7 4188 28 related relate VBN cord-005453-4057qib7 4188 29 with with IN cord-005453-4057qib7 4188 30 transplantation transplantation NN cord-005453-4057qib7 4188 31 was be VBD cord-005453-4057qib7 4188 32 35 35 CD cord-005453-4057qib7 4188 33 % % NN cord-005453-4057qib7 4188 34 vs vs IN cord-005453-4057qib7 4188 35 13 13 CD cord-005453-4057qib7 4188 36 % % NN cord-005453-4057qib7 4188 37 respectively respectively RB cord-005453-4057qib7 4188 38 . . . cord-005453-4057qib7 4189 1 Conclusions conclusion NNS cord-005453-4057qib7 4189 2 : : : cord-005453-4057qib7 4190 1 ABO ABO NNP cord-005453-4057qib7 4190 2 incompatibility incompatibility NN cord-005453-4057qib7 4190 3 did do VBD cord-005453-4057qib7 4190 4 not not RB cord-005453-4057qib7 4190 5 show show VB cord-005453-4057qib7 4190 6 association association NN cord-005453-4057qib7 4190 7 with with IN cord-005453-4057qib7 4190 8 complications complication NNS cord-005453-4057qib7 4190 9 related relate VBN cord-005453-4057qib7 4190 10 with with IN cord-005453-4057qib7 4190 11 the the DT cord-005453-4057qib7 4190 12 infusion infusion NN cord-005453-4057qib7 4190 13 , , , cord-005453-4057qib7 4190 14 but but CC cord-005453-4057qib7 4190 15 there there EX cord-005453-4057qib7 4190 16 was be VBD cord-005453-4057qib7 4190 17 a a DT cord-005453-4057qib7 4190 18 higher high JJR cord-005453-4057qib7 4190 19 tendency tendency NN cord-005453-4057qib7 4190 20 of of IN cord-005453-4057qib7 4190 21 graft graft NN cord-005453-4057qib7 4190 22 failure failure NN cord-005453-4057qib7 4190 23 in in IN cord-005453-4057qib7 4190 24 the the DT cord-005453-4057qib7 4190 25 ABO ABO NNP cord-005453-4057qib7 4190 26 incompatibility incompatibility NN cord-005453-4057qib7 4190 27 group group NN cord-005453-4057qib7 4190 28 . . . cord-005453-4057qib7 4191 1 It -PRON- PRP cord-005453-4057qib7 4191 2 has have VBZ cord-005453-4057qib7 4191 3 no no DT cord-005453-4057qib7 4191 4 statistical statistical JJ cord-005453-4057qib7 4191 5 significance significance NN cord-005453-4057qib7 4191 6 , , , cord-005453-4057qib7 4191 7 but but CC cord-005453-4057qib7 4191 8 it -PRON- PRP cord-005453-4057qib7 4191 9 is be VBZ cord-005453-4057qib7 4191 10 important important JJ cord-005453-4057qib7 4191 11 to to TO cord-005453-4057qib7 4191 12 expand expand VB cord-005453-4057qib7 4191 13 its -PRON- PRP$ cord-005453-4057qib7 4191 14 study study NN cord-005453-4057qib7 4191 15 . . . cord-005453-4057qib7 4192 1 Disclosure disclosure NN cord-005453-4057qib7 4192 2 : : : cord-005453-4057qib7 4193 1 None none NN cord-005453-4057qib7 4193 2 declared declare VBD cord-005453-4057qib7 4193 3 Methods method NNS cord-005453-4057qib7 4193 4 : : : cord-005453-4057qib7 4193 5 Retrospective retrospective JJ cord-005453-4057qib7 4193 6 data datum NNS cord-005453-4057qib7 4193 7 for for IN cord-005453-4057qib7 4193 8 142 142 CD cord-005453-4057qib7 4193 9 NHL NHL NNP cord-005453-4057qib7 4193 10 patients patient NNS cord-005453-4057qib7 4193 11 who who WP cord-005453-4057qib7 4193 12 underwent undergo VBD cord-005453-4057qib7 4193 13 ASCT ASCT NNP cord-005453-4057qib7 4193 14 between between IN cord-005453-4057qib7 4193 15 1999 1999 CD cord-005453-4057qib7 4193 16 and and CC cord-005453-4057qib7 4193 17 2017 2017 CD cord-005453-4057qib7 4193 18 was be VBD cord-005453-4057qib7 4193 19 analysed analyse VBN cord-005453-4057qib7 4193 20 . . . cord-005453-4057qib7 4194 1 Patients patient NNS cord-005453-4057qib7 4194 2 were be VBD cord-005453-4057qib7 4194 3 identified identify VBN cord-005453-4057qib7 4194 4 using use VBG cord-005453-4057qib7 4194 5 the the DT cord-005453-4057qib7 4194 6 SWBMT SWBMT NNP cord-005453-4057qib7 4194 7 database database NN cord-005453-4057qib7 4194 8 and and CC cord-005453-4057qib7 4194 9 data datum NNS cord-005453-4057qib7 4194 10 on on IN cord-005453-4057qib7 4194 11 MetS MetS NNP cord-005453-4057qib7 4194 12 was be VBD cord-005453-4057qib7 4194 13 collected collect VBN cord-005453-4057qib7 4194 14 using use VBG cord-005453-4057qib7 4194 15 paper paper NN cord-005453-4057qib7 4194 16 and and CC cord-005453-4057qib7 4194 17 electronic electronic JJ cord-005453-4057qib7 4194 18 hospital hospital NN cord-005453-4057qib7 4194 19 records record NNS cord-005453-4057qib7 4194 20 . . . cord-005453-4057qib7 4195 1 Forty forty CD cord-005453-4057qib7 4195 2 - - HYPH cord-005453-4057qib7 4195 3 eight eight CD cord-005453-4057qib7 4195 4 patients patient NNS cord-005453-4057qib7 4195 5 were be VBD cord-005453-4057qib7 4195 6 excluded exclude VBN cord-005453-4057qib7 4195 7 due due IN cord-005453-4057qib7 4195 8 to to IN cord-005453-4057qib7 4195 9 loss loss NN cord-005453-4057qib7 4195 10 of of IN cord-005453-4057qib7 4195 11 follow follow NN cord-005453-4057qib7 4195 12 - - HYPH cord-005453-4057qib7 4195 13 up up NN cord-005453-4057qib7 4195 14 , , , cord-005453-4057qib7 4195 15 inaccessible inaccessible JJ cord-005453-4057qib7 4195 16 / / SYM cord-005453-4057qib7 4195 17 incomplete incomplete JJ cord-005453-4057qib7 4195 18 records record NNS cord-005453-4057qib7 4195 19 , , , cord-005453-4057qib7 4195 20 or or CC cord-005453-4057qib7 4195 21 death death NN cord-005453-4057qib7 4195 22 . . . cord-005453-4057qib7 4196 1 Cause cause NN cord-005453-4057qib7 4196 2 of of IN cord-005453-4057qib7 4196 3 death death NN cord-005453-4057qib7 4196 4 was be VBD cord-005453-4057qib7 4196 5 not not RB cord-005453-4057qib7 4196 6 determined determine VBN cord-005453-4057qib7 4196 7 . . . cord-005453-4057qib7 4197 1 The the DT cord-005453-4057qib7 4197 2 NCEP NCEP NNP cord-005453-4057qib7 4197 3 - - HYPH cord-005453-4057qib7 4197 4 ATPIII ATPIII NNP cord-005453-4057qib7 4197 5 definition definition NN cord-005453-4057qib7 4197 6 of of IN cord-005453-4057qib7 4197 7 MetS MetS NNP cord-005453-4057qib7 4197 8 was be VBD cord-005453-4057qib7 4197 9 used use VBN cord-005453-4057qib7 4197 10 . . . cord-005453-4057qib7 4198 1 This this DT cord-005453-4057qib7 4198 2 requires require VBZ cord-005453-4057qib7 4198 3 ≥3 ≥3 NN cord-005453-4057qib7 4198 4 of of IN cord-005453-4057qib7 4198 5 5 5 CD cord-005453-4057qib7 4198 6 criteria criterion NNS cord-005453-4057qib7 4198 7 to to TO cord-005453-4057qib7 4198 8 be be VB cord-005453-4057qib7 4198 9 met meet VBN cord-005453-4057qib7 4198 10 . . . cord-005453-4057qib7 4199 1 A a DT cord-005453-4057qib7 4199 2 BMI bmi NN cord-005453-4057qib7 4199 3 of of IN cord-005453-4057qib7 4199 4 ≥30kg ≥30kg NNP cord-005453-4057qib7 4199 5 / / SYM cord-005453-4057qib7 4199 6 m m NNP cord-005453-4057qib7 4199 7 2 2 CD cord-005453-4057qib7 4199 8 and and CC cord-005453-4057qib7 4199 9 HbA1c hba1c NN cord-005453-4057qib7 4199 10 of of IN cord-005453-4057qib7 4199 11 ≥42mmol ≥42mmol NNP cord-005453-4057qib7 4199 12 / / SYM cord-005453-4057qib7 4199 13 L L NNP cord-005453-4057qib7 4199 14 were be VBD cord-005453-4057qib7 4199 15 used use VBN cord-005453-4057qib7 4199 16 to to TO cord-005453-4057qib7 4199 17 replace replace VB cord-005453-4057qib7 4199 18 central central JJ cord-005453-4057qib7 4199 19 obesity obesity NN cord-005453-4057qib7 4199 20 and and CC cord-005453-4057qib7 4199 21 impaired impair VBN cord-005453-4057qib7 4199 22 fasting fast VBG cord-005453-4057qib7 4199 23 glucose glucose NN cord-005453-4057qib7 4199 24 , , , cord-005453-4057qib7 4199 25 respectively respectively RB cord-005453-4057qib7 4199 26 . . . cord-005453-4057qib7 4200 1 Other other JJ cord-005453-4057qib7 4200 2 criteria criterion NNS cord-005453-4057qib7 4200 3 include include VBP cord-005453-4057qib7 4200 4 triglycerides triglyceride NNS cord-005453-4057qib7 4200 5 ( ( -LRB- cord-005453-4057qib7 4200 6 TGs tg NNS cord-005453-4057qib7 4200 7 ) ) -RRB- cord-005453-4057qib7 4201 1 ≥1.7mmol ≥1.7mmol NNP cord-005453-4057qib7 4201 2 / / SYM cord-005453-4057qib7 4201 3 L l NN cord-005453-4057qib7 4201 4 or or CC cord-005453-4057qib7 4201 5 treatment treatment NN cord-005453-4057qib7 4201 6 , , , cord-005453-4057qib7 4201 7 high high JJ cord-005453-4057qib7 4201 8 density density NN cord-005453-4057qib7 4201 9 lipoprotein lipoprotein NN cord-005453-4057qib7 4201 10 cholesterol cholesterol NN cord-005453-4057qib7 4201 11 ( ( -LRB- cord-005453-4057qib7 4201 12 HDL HDL NNP cord-005453-4057qib7 4201 13 - - HYPH cord-005453-4057qib7 4201 14 C C NNP cord-005453-4057qib7 4201 15 ) ) -RRB- cord-005453-4057qib7 4202 1 < < XX cord-005453-4057qib7 4203 1 1.0mmol 1.0mmol LS cord-005453-4057qib7 4203 2 / / SYM cord-005453-4057qib7 4203 3 L L NNP cord-005453-4057qib7 4203 4 ( ( -LRB- cord-005453-4057qib7 4203 5 male male NNP cord-005453-4057qib7 4203 6 ) ) -RRB- cord-005453-4057qib7 4203 7 , , , cord-005453-4057qib7 4203 8 < < XX cord-005453-4057qib7 4203 9 1.3mmol 1.3mmol NNP cord-005453-4057qib7 4203 10 / / SYM cord-005453-4057qib7 4203 11 L L NNP cord-005453-4057qib7 4203 12 ( ( -LRB- cord-005453-4057qib7 4203 13 female female JJ cord-005453-4057qib7 4203 14 ) ) -RRB- cord-005453-4057qib7 4203 15 or or CC cord-005453-4057qib7 4203 16 treatment treatment NN cord-005453-4057qib7 4203 17 and and CC cord-005453-4057qib7 4203 18 blood blood NN cord-005453-4057qib7 4203 19 pressure pressure NN cord-005453-4057qib7 4203 20 > > XX cord-005453-4057qib7 4204 1 130mmHg 130mmhg CD cord-005453-4057qib7 4204 2 systolic systolic JJ cord-005453-4057qib7 4204 3 or or CC cord-005453-4057qib7 4204 4 > > XX cord-005453-4057qib7 4204 5 85mmHg 85mmhg CD cord-005453-4057qib7 4204 6 diastolic diastolic JJ cord-005453-4057qib7 4204 7 , , , cord-005453-4057qib7 4204 8 or or CC cord-005453-4057qib7 4204 9 treatment treatment NN cord-005453-4057qib7 4204 10 . . . cord-005453-4057qib7 4205 1 Results result NNS cord-005453-4057qib7 4205 2 : : : cord-005453-4057qib7 4206 1 The the DT cord-005453-4057qib7 4206 2 prevalence prevalence NN cord-005453-4057qib7 4206 3 of of IN cord-005453-4057qib7 4206 4 MetS met NNS cord-005453-4057qib7 4206 5 in in IN cord-005453-4057qib7 4206 6 the the DT cord-005453-4057qib7 4206 7 cohort cohort NN cord-005453-4057qib7 4206 8 was be VBD cord-005453-4057qib7 4206 9 33 33 CD cord-005453-4057qib7 4206 10 % % NN cord-005453-4057qib7 4206 11 ( ( -LRB- cord-005453-4057qib7 4206 12 n=31 n=31 NNP cord-005453-4057qib7 4206 13 ) ) -RRB- cord-005453-4057qib7 4206 14 . . . cord-005453-4057qib7 4207 1 Eighty eighty CD cord-005453-4057qib7 4207 2 - - HYPH cord-005453-4057qib7 4207 3 two two CD cord-005453-4057qib7 4207 4 percent percent NN cord-005453-4057qib7 4207 5 of of IN cord-005453-4057qib7 4207 6 patients patient NNS cord-005453-4057qib7 4207 7 ( ( -LRB- cord-005453-4057qib7 4207 8 n=77 n=77 RB cord-005453-4057qib7 4207 9 ) ) -RRB- cord-005453-4057qib7 4207 10 met meet VBD cord-005453-4057qib7 4207 11 one one CD cord-005453-4057qib7 4207 12 or or CC cord-005453-4057qib7 4207 13 more more JJR cord-005453-4057qib7 4207 14 criterion criterion NN cord-005453-4057qib7 4207 15 for for IN cord-005453-4057qib7 4207 16 MetS. MetS. NNP cord-005453-4057qib7 4208 1 Twenty twenty CD cord-005453-4057qib7 4208 2 - - HYPH cord-005453-4057qib7 4208 3 seven seven CD cord-005453-4057qib7 4208 4 percent percent NN cord-005453-4057qib7 4208 5 ( ( -LRB- cord-005453-4057qib7 4208 6 n=25 n=25 NN cord-005453-4057qib7 4208 7 ) ) -RRB- cord-005453-4057qib7 4208 8 fulfilled fulfil VBD cord-005453-4057qib7 4208 9 only only RB cord-005453-4057qib7 4208 10 one one CD cord-005453-4057qib7 4208 11 criterion criterion NN cord-005453-4057qib7 4208 12 , , , cord-005453-4057qib7 4208 13 23 23 CD cord-005453-4057qib7 4208 14 % % NN cord-005453-4057qib7 4208 15 ( ( -LRB- cord-005453-4057qib7 4208 16 n=22 n=22 NNP cord-005453-4057qib7 4208 17 ) ) -RRB- cord-005453-4057qib7 4208 18 fulfilled fulfil VBD cord-005453-4057qib7 4208 19 two two CD cord-005453-4057qib7 4208 20 criteria criterion NNS cord-005453-4057qib7 4208 21 , , , cord-005453-4057qib7 4208 22 20 20 CD cord-005453-4057qib7 4208 23 % % NN cord-005453-4057qib7 4208 24 ( ( -LRB- cord-005453-4057qib7 4208 25 n=19 n=19 NN cord-005453-4057qib7 4208 26 ) ) -RRB- cord-005453-4057qib7 4209 1 three three CD cord-005453-4057qib7 4209 2 criteria criterion NNS cord-005453-4057qib7 4209 3 , , , cord-005453-4057qib7 4209 4 12 12 CD cord-005453-4057qib7 4209 5 % % NN cord-005453-4057qib7 4209 6 ( ( -LRB- cord-005453-4057qib7 4209 7 n=11 n=11 NNP cord-005453-4057qib7 4209 8 ) ) -RRB- cord-005453-4057qib7 4209 9 four four CD cord-005453-4057qib7 4209 10 criteria criterion NNS cord-005453-4057qib7 4209 11 , , , cord-005453-4057qib7 4209 12 and and CC cord-005453-4057qib7 4209 13 1 1 CD cord-005453-4057qib7 4209 14 % % NN cord-005453-4057qib7 4209 15 ( ( -LRB- cord-005453-4057qib7 4209 16 n=1 n=1 CD cord-005453-4057qib7 4209 17 ) ) -RRB- cord-005453-4057qib7 4209 18 five five CD cord-005453-4057qib7 4209 19 criteria criterion NNS cord-005453-4057qib7 4209 20 . . . cord-005453-4057qib7 4210 1 The the DT cord-005453-4057qib7 4210 2 greatest great JJS cord-005453-4057qib7 4210 3 prevalence prevalence NN cord-005453-4057qib7 4210 4 of of IN cord-005453-4057qib7 4210 5 MetS MetS NNP cord-005453-4057qib7 4210 6 was be VBD cord-005453-4057qib7 4210 7 in in IN cord-005453-4057qib7 4210 8 the the DT cord-005453-4057qib7 4210 9 60 60 CD cord-005453-4057qib7 4210 10 + + CC cord-005453-4057qib7 4210 11 age age NN cord-005453-4057qib7 4210 12 group group NN cord-005453-4057qib7 4210 13 , , , cord-005453-4057qib7 4210 14 accounting account VBG cord-005453-4057qib7 4210 15 for for IN cord-005453-4057qib7 4210 16 17 17 CD cord-005453-4057qib7 4210 17 out out IN cord-005453-4057qib7 4210 18 of of IN cord-005453-4057qib7 4210 19 31 31 CD cord-005453-4057qib7 4210 20 ( ( -LRB- cord-005453-4057qib7 4210 21 55 55 CD cord-005453-4057qib7 4210 22 % % NN cord-005453-4057qib7 4210 23 ) ) -RRB- cord-005453-4057qib7 4210 24 patients patient NNS cord-005453-4057qib7 4210 25 with with IN cord-005453-4057qib7 4210 26 MetS. MetS. NNP cord-005453-4057qib7 4211 1 Overall overall JJ cord-005453-4057qib7 4211 2 prevalence prevalence NN cord-005453-4057qib7 4211 3 decreased decrease VBD cord-005453-4057qib7 4211 4 with with IN cord-005453-4057qib7 4211 5 declining decline VBG cord-005453-4057qib7 4211 6 age age NN cord-005453-4057qib7 4211 7 ( ( -LRB- cord-005453-4057qib7 4211 8 Table table NN cord-005453-4057qib7 4211 9 1 1 CD cord-005453-4057qib7 4211 10 ) ) -RRB- cord-005453-4057qib7 4211 11 . . . cord-005453-4057qib7 4212 1 The the DT cord-005453-4057qib7 4212 2 number number NN cord-005453-4057qib7 4212 3 of of IN cord-005453-4057qib7 4212 4 patients patient NNS cord-005453-4057qib7 4212 5 aged age VBN cord-005453-4057qib7 4212 6 < < XX cord-005453-4057qib7 4212 7 20 20 CD cord-005453-4057qib7 4212 8 years year NNS cord-005453-4057qib7 4212 9 was be VBD cord-005453-4057qib7 4212 10 too too RB cord-005453-4057qib7 4212 11 small small JJ cord-005453-4057qib7 4212 12 to to TO cord-005453-4057qib7 4212 13 make make VB cord-005453-4057qib7 4212 14 any any DT cord-005453-4057qib7 4212 15 judgement judgement NN cord-005453-4057qib7 4212 16 on on IN cord-005453-4057qib7 4212 17 risk risk NN cord-005453-4057qib7 4212 18 . . . cord-005453-4057qib7 4213 1 Raised raise VBN cord-005453-4057qib7 4213 2 triglycerides triglyceride NNS cord-005453-4057qib7 4213 3 was be VBD cord-005453-4057qib7 4213 4 the the DT cord-005453-4057qib7 4213 5 criterion criterion NN cord-005453-4057qib7 4213 6 most most RBS cord-005453-4057qib7 4213 7 frequently frequently RB cord-005453-4057qib7 4213 8 met meet VBD cord-005453-4057qib7 4213 9 ( ( -LRB- cord-005453-4057qib7 4213 10 61/94 61/94 CD cord-005453-4057qib7 4213 11 patients patient NNS cord-005453-4057qib7 4213 12 ) ) -RRB- cord-005453-4057qib7 4213 13 , , , cord-005453-4057qib7 4213 14 followed follow VBN cord-005453-4057qib7 4213 15 by by IN cord-005453-4057qib7 4213 16 hypertension hypertension NN cord-005453-4057qib7 4213 17 ( ( -LRB- cord-005453-4057qib7 4213 18 48 48 CD cord-005453-4057qib7 4213 19 ) ) -RRB- cord-005453-4057qib7 4213 20 , , , cord-005453-4057qib7 4213 21 raised raise VBD cord-005453-4057qib7 4213 22 BMI BMI NNP cord-005453-4057qib7 4213 23 ( ( -LRB- cord-005453-4057qib7 4213 24 26 26 CD cord-005453-4057qib7 4213 25 ) ) -RRB- cord-005453-4057qib7 4213 26 , , , cord-005453-4057qib7 4213 27 low low JJ cord-005453-4057qib7 4213 28 HDL HDL NNP cord-005453-4057qib7 4213 29 - - HYPH cord-005453-4057qib7 4213 30 C C NNP cord-005453-4057qib7 4213 31 ( ( -LRB- cord-005453-4057qib7 4213 32 23 23 CD cord-005453-4057qib7 4213 33 ) ) -RRB- cord-005453-4057qib7 4213 34 and and CC cord-005453-4057qib7 4213 35 an an DT cord-005453-4057qib7 4213 36 increased increase VBN cord-005453-4057qib7 4213 37 HbA1c hba1c NN cord-005453-4057qib7 4213 38 ( ( -LRB- cord-005453-4057qib7 4213 39 15 15 CD cord-005453-4057qib7 4213 40 ) ) -RRB- cord-005453-4057qib7 4213 41 . . . cord-005453-4057qib7 4214 1 Conclusions conclusion NNS cord-005453-4057qib7 4214 2 : : : cord-005453-4057qib7 4215 1 The the DT cord-005453-4057qib7 4215 2 prevalence prevalence NN cord-005453-4057qib7 4215 3 of of IN cord-005453-4057qib7 4215 4 MetS met NNS cord-005453-4057qib7 4215 5 in in IN cord-005453-4057qib7 4215 6 our -PRON- PRP$ cord-005453-4057qib7 4215 7 cohort cohort NN cord-005453-4057qib7 4215 8 ( ( -LRB- cord-005453-4057qib7 4215 9 33 33 CD cord-005453-4057qib7 4215 10 % % NN cord-005453-4057qib7 4215 11 ) ) -RRB- cord-005453-4057qib7 4215 12 was be VBD cord-005453-4057qib7 4215 13 higher high JJR cord-005453-4057qib7 4215 14 than than IN cord-005453-4057qib7 4215 15 the the DT cord-005453-4057qib7 4215 16 estimated estimate VBN cord-005453-4057qib7 4215 17 worldwide worldwide JJ cord-005453-4057qib7 4215 18 prevalence prevalence NN cord-005453-4057qib7 4215 19 of of IN cord-005453-4057qib7 4215 20 25 25 CD cord-005453-4057qib7 4215 21 % % NN cord-005453-4057qib7 4215 22 , , , cord-005453-4057qib7 4215 23 with with IN cord-005453-4057qib7 4215 24 the the DT cord-005453-4057qib7 4215 25 majority majority NN cord-005453-4057qib7 4215 26 in in IN cord-005453-4057qib7 4215 27 the the DT cord-005453-4057qib7 4215 28 60 60 CD cord-005453-4057qib7 4215 29 + + CC cord-005453-4057qib7 4215 30 age age NN cord-005453-4057qib7 4215 31 category category NN cord-005453-4057qib7 4215 32 . . . cord-005453-4057qib7 4216 1 This this DT cord-005453-4057qib7 4216 2 is be VBZ cord-005453-4057qib7 4216 3 in in IN cord-005453-4057qib7 4216 4 keeping keep VBG cord-005453-4057qib7 4216 5 with with IN cord-005453-4057qib7 4216 6 other other JJ cord-005453-4057qib7 4216 7 post post JJ cord-005453-4057qib7 4216 8 - - JJ cord-005453-4057qib7 4216 9 transplant transplant JJ cord-005453-4057qib7 4216 10 studies study NNS cord-005453-4057qib7 4216 11 , , , cord-005453-4057qib7 4216 12 which which WDT cord-005453-4057qib7 4216 13 show show VBP cord-005453-4057qib7 4216 14 an an DT cord-005453-4057qib7 4216 15 increase increase NN cord-005453-4057qib7 4216 16 in in IN cord-005453-4057qib7 4216 17 prevalence prevalence NN cord-005453-4057qib7 4216 18 of of IN cord-005453-4057qib7 4216 19 MetS mets NN cord-005453-4057qib7 4216 20 after after IN cord-005453-4057qib7 4216 21 transplantation transplantation NN cord-005453-4057qib7 4216 22 . . . cord-005453-4057qib7 4217 1 Moreover moreover RB cord-005453-4057qib7 4217 2 , , , cord-005453-4057qib7 4217 3 the the DT cord-005453-4057qib7 4217 4 overall overall JJ cord-005453-4057qib7 4217 5 prevalence prevalence NN cord-005453-4057qib7 4217 6 of of IN cord-005453-4057qib7 4217 7 MetS MetS NNP cord-005453-4057qib7 4217 8 was be VBD cord-005453-4057qib7 4217 9 greater great JJR cord-005453-4057qib7 4217 10 in in IN cord-005453-4057qib7 4217 11 the the DT cord-005453-4057qib7 4217 12 older old JJR cord-005453-4057qib7 4217 13 population population NN cord-005453-4057qib7 4217 14 , , , cord-005453-4057qib7 4217 15 which which WDT cord-005453-4057qib7 4217 16 could could MD cord-005453-4057qib7 4217 17 be be VB cord-005453-4057qib7 4217 18 associated associate VBN cord-005453-4057qib7 4217 19 with with IN cord-005453-4057qib7 4217 20 the the DT cord-005453-4057qib7 4217 21 cumulative cumulative JJ cord-005453-4057qib7 4217 22 effect effect NN cord-005453-4057qib7 4217 23 of of IN cord-005453-4057qib7 4217 24 ageing age VBG cord-005453-4057qib7 4217 25 on on IN cord-005453-4057qib7 4217 26 the the DT cord-005453-4057qib7 4217 27 decline decline NN cord-005453-4057qib7 4217 28 of of IN cord-005453-4057qib7 4217 29 normal normal JJ cord-005453-4057qib7 4217 30 metabolic metabolic JJ cord-005453-4057qib7 4217 31 homeostatic homeostatic JJ cord-005453-4057qib7 4217 32 mechanisms mechanism NNS cord-005453-4057qib7 4217 33 . . . cord-005453-4057qib7 4218 1 Background background NN cord-005453-4057qib7 4218 2 : : : cord-005453-4057qib7 4219 1 Acute acute JJ cord-005453-4057qib7 4219 2 renal renal JJ cord-005453-4057qib7 4219 3 failure failure NN cord-005453-4057qib7 4219 4 ( ( -LRB- cord-005453-4057qib7 4219 5 ARF ARF NNP cord-005453-4057qib7 4219 6 ) ) -RRB- cord-005453-4057qib7 4219 7 is be VBZ cord-005453-4057qib7 4219 8 a a DT cord-005453-4057qib7 4219 9 frequent frequent JJ cord-005453-4057qib7 4219 10 complication complication NN cord-005453-4057qib7 4219 11 in in IN cord-005453-4057qib7 4219 12 the the DT cord-005453-4057qib7 4219 13 early early JJ cord-005453-4057qib7 4219 14 post post JJ cord-005453-4057qib7 4219 15 - - JJ cord-005453-4057qib7 4219 16 allogeneic allogeneic JJ cord-005453-4057qib7 4219 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 4219 18 stem stem NN cord-005453-4057qib7 4219 19 cell cell NN cord-005453-4057qib7 4219 20 transplant transplant NN cord-005453-4057qib7 4219 21 ( ( -LRB- cord-005453-4057qib7 4219 22 alloHSCT alloHSCT NNP cord-005453-4057qib7 4219 23 ) ) -RRB- cord-005453-4057qib7 4219 24 period period NN cord-005453-4057qib7 4219 25 with with IN cord-005453-4057qib7 4219 26 either either DT cord-005453-4057qib7 4219 27 myeloablative myeloablative NNP cord-005453-4057qib7 4219 28 ( ( -LRB- cord-005453-4057qib7 4219 29 MA MA NNP cord-005453-4057qib7 4219 30 ) ) -RRB- cord-005453-4057qib7 4219 31 or or CC cord-005453-4057qib7 4219 32 non non JJ cord-005453-4057qib7 4219 33 - - JJ cord-005453-4057qib7 4219 34 myeloablative myeloablative JJ cord-005453-4057qib7 4219 35 ( ( -LRB- cord-005453-4057qib7 4219 36 NMA NMA NNP cord-005453-4057qib7 4219 37 ) ) -RRB- cord-005453-4057qib7 4219 38 conditioning conditioning NN cord-005453-4057qib7 4219 39 regimens regimen NNS cord-005453-4057qib7 4219 40 . . . cord-005453-4057qib7 4220 1 The the DT cord-005453-4057qib7 4220 2 aim aim NN cord-005453-4057qib7 4220 3 of of IN cord-005453-4057qib7 4220 4 this this DT cord-005453-4057qib7 4220 5 study study NN cord-005453-4057qib7 4220 6 was be VBD cord-005453-4057qib7 4220 7 to to TO cord-005453-4057qib7 4220 8 compare compare VB cord-005453-4057qib7 4220 9 the the DT cord-005453-4057qib7 4220 10 incidence incidence NN cord-005453-4057qib7 4220 11 of of IN cord-005453-4057qib7 4220 12 ARF arf NN cord-005453-4057qib7 4220 13 in in IN cord-005453-4057qib7 4220 14 both both DT cord-005453-4057qib7 4220 15 types type NNS cord-005453-4057qib7 4220 16 of of IN cord-005453-4057qib7 4220 17 HSCT HSCT NNP cord-005453-4057qib7 4220 18 and and CC cord-005453-4057qib7 4220 19 to to TO cord-005453-4057qib7 4220 20 evaluate evaluate VB cord-005453-4057qib7 4220 21 its -PRON- PRP$ cord-005453-4057qib7 4220 22 impact impact NN cord-005453-4057qib7 4220 23 on on IN cord-005453-4057qib7 4220 24 overall overall JJ cord-005453-4057qib7 4220 25 survival survival NN cord-005453-4057qib7 4220 26 ( ( -LRB- cord-005453-4057qib7 4220 27 OS OS NNP cord-005453-4057qib7 4220 28 ) ) -RRB- cord-005453-4057qib7 4220 29 and and CC cord-005453-4057qib7 4220 30 non non JJ cord-005453-4057qib7 4220 31 - - JJ cord-005453-4057qib7 4220 32 relapse relapse JJ cord-005453-4057qib7 4220 33 mortality mortality NN cord-005453-4057qib7 4220 34 ( ( -LRB- cord-005453-4057qib7 4220 35 NRM NRM NNP cord-005453-4057qib7 4220 36 ) ) -RRB- cord-005453-4057qib7 4220 37 . . . cord-005453-4057qib7 4221 1 Methods method NNS cord-005453-4057qib7 4221 2 : : : cord-005453-4057qib7 4221 3 All all DT cord-005453-4057qib7 4221 4 alloSCT alloSCT NNP cord-005453-4057qib7 4221 5 performed perform VBN cord-005453-4057qib7 4221 6 in in IN cord-005453-4057qib7 4221 7 one one CD cord-005453-4057qib7 4221 8 center center NN cord-005453-4057qib7 4221 9 between between IN cord-005453-4057qib7 4221 10 2010 2010 CD cord-005453-4057qib7 4221 11 and and CC cord-005453-4057qib7 4221 12 2018 2018 CD cord-005453-4057qib7 4221 13 were be VBD cord-005453-4057qib7 4221 14 included include VBN cord-005453-4057qib7 4221 15 in in IN cord-005453-4057qib7 4221 16 this this DT cord-005453-4057qib7 4221 17 study study NN cord-005453-4057qib7 4221 18 . . . cord-005453-4057qib7 4222 1 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 4222 2 from from IN cord-005453-4057qib7 4222 3 cord cord NN cord-005453-4057qib7 4222 4 blood blood NN cord-005453-4057qib7 4222 5 and and CC cord-005453-4057qib7 4222 6 from from IN cord-005453-4057qib7 4222 7 haploidentical haploidentical JJ cord-005453-4057qib7 4222 8 donors donor NNS cord-005453-4057qib7 4222 9 were be VBD cord-005453-4057qib7 4222 10 excluded exclude VBN cord-005453-4057qib7 4222 11 . . . cord-005453-4057qib7 4223 1 The the DT cord-005453-4057qib7 4223 2 renal renal JJ cord-005453-4057qib7 4223 3 function function NN cord-005453-4057qib7 4223 4 and and CC cord-005453-4057qib7 4223 5 the the DT cord-005453-4057qib7 4223 6 incidence incidence NN cord-005453-4057qib7 4223 7 of of IN cord-005453-4057qib7 4223 8 the the DT cord-005453-4057qib7 4223 9 main main JJ cord-005453-4057qib7 4223 10 complications complication NNS cord-005453-4057qib7 4223 11 after after IN cord-005453-4057qib7 4223 12 alloSCT alloSCT NNP cord-005453-4057qib7 4223 13 from from IN cord-005453-4057qib7 4223 14 day day NN cord-005453-4057qib7 4223 15 0 0 CD cord-005453-4057qib7 4223 16 to to IN cord-005453-4057qib7 4223 17 day day NN cord-005453-4057qib7 4223 18 +90 +90 CD cord-005453-4057qib7 4223 19 were be VBD cord-005453-4057qib7 4223 20 evaluated evaluate VBN cord-005453-4057qib7 4223 21 . . . cord-005453-4057qib7 4224 1 ARF ARF NNP cord-005453-4057qib7 4224 2 was be VBD cord-005453-4057qib7 4224 3 defined define VBN cord-005453-4057qib7 4224 4 according accord VBG cord-005453-4057qib7 4224 5 to to IN cord-005453-4057qib7 4224 6 KDIGO KDIGO NNP cord-005453-4057qib7 4224 7 ( ( -LRB- cord-005453-4057qib7 4224 8 Kidney Kidney NNP cord-005453-4057qib7 4224 9 Disease Disease NNP cord-005453-4057qib7 4224 10 Improving Improving NNP cord-005453-4057qib7 4224 11 Global Global NNP cord-005453-4057qib7 4224 12 Outcomes Outcomes NNPS cord-005453-4057qib7 4224 13 ) ) -RRB- cord-005453-4057qib7 4224 14 classification classification NN cord-005453-4057qib7 4224 15 ; ; : cord-005453-4057qib7 4224 16 the the DT cord-005453-4057qib7 4224 17 relative relative JJ cord-005453-4057qib7 4224 18 increase increase NN cord-005453-4057qib7 4224 19 of of IN cord-005453-4057qib7 4224 20 serum serum NN cord-005453-4057qib7 4224 21 creatinine creatinine NN cord-005453-4057qib7 4224 22 levels level NNS cord-005453-4057qib7 4224 23 was be VBD cord-005453-4057qib7 4224 24 considered consider VBN cord-005453-4057qib7 4224 25 a a DT cord-005453-4057qib7 4224 26 marker marker NN cord-005453-4057qib7 4224 27 of of IN cord-005453-4057qib7 4224 28 kidney kidney NN cord-005453-4057qib7 4224 29 damage damage NN cord-005453-4057qib7 4224 30 . . . cord-005453-4057qib7 4225 1 Results result NNS cord-005453-4057qib7 4225 2 : : : cord-005453-4057qib7 4226 1 Seventy seventy CD cord-005453-4057qib7 4226 2 - - HYPH cord-005453-4057qib7 4226 3 seven seven CD cord-005453-4057qib7 4226 4 patients patient NNS cord-005453-4057qib7 4226 5 received receive VBD cord-005453-4057qib7 4226 6 a a DT cord-005453-4057qib7 4226 7 MA MA NNP cord-005453-4057qib7 4226 8 alloHSCT allohsct NN cord-005453-4057qib7 4226 9 and and CC cord-005453-4057qib7 4226 10 72 72 CD cord-005453-4057qib7 4226 11 a a DT cord-005453-4057qib7 4226 12 NMA NMA NNP cord-005453-4057qib7 4226 13 alloHSCT allohsct NN cord-005453-4057qib7 4226 14 . . . cord-005453-4057qib7 4227 1 Recipients recipient NNS cord-005453-4057qib7 4227 2 of of IN cord-005453-4057qib7 4227 3 NMA NMA NNP cord-005453-4057qib7 4227 4 alloHSCT alloHSCT NNP cord-005453-4057qib7 4227 5 had have VBD cord-005453-4057qib7 4227 6 a a DT cord-005453-4057qib7 4227 7 higher high JJR cord-005453-4057qib7 4227 8 median median NN cord-005453-4057qib7 4227 9 age age NN cord-005453-4057qib7 4227 10 ( ( -LRB- cord-005453-4057qib7 4227 11 61 61 CD cord-005453-4057qib7 4227 12 years year NNS cord-005453-4057qib7 4228 1 [ [ -LRB- cord-005453-4057qib7 4228 2 range range NN cord-005453-4057qib7 4228 3 : : : cord-005453-4057qib7 4228 4 18 18 CD cord-005453-4057qib7 4228 5 - - SYM cord-005453-4057qib7 4228 6 69 69 CD cord-005453-4057qib7 4228 7 ] ] -RRB- cord-005453-4057qib7 4228 8 vs. vs. NN cord-005453-4057qib7 4228 9 41 41 CD cord-005453-4057qib7 4228 10 years year NNS cord-005453-4057qib7 4228 11 , , , cord-005453-4057qib7 4228 12 p p NN cord-005453-4057qib7 4228 13 < < XX cord-005453-4057qib7 4228 14 0.001 0.001 CD cord-005453-4057qib7 4228 15 ) ) -RRB- cord-005453-4057qib7 4228 16 , , , cord-005453-4057qib7 4228 17 higher high JJR cord-005453-4057qib7 4228 18 frequency frequency NN cord-005453-4057qib7 4228 19 of of IN cord-005453-4057qib7 4228 20 arterial arterial JJ cord-005453-4057qib7 4228 21 hypertension hypertension NN cord-005453-4057qib7 4228 22 ( ( -LRB- cord-005453-4057qib7 4228 23 29 29 CD cord-005453-4057qib7 4228 24 % % NN cord-005453-4057qib7 4228 25 vs. vs. CC cord-005453-4057qib7 4228 26 6 6 CD cord-005453-4057qib7 4228 27 % % NN cord-005453-4057qib7 4228 28 , , , cord-005453-4057qib7 4228 29 p p NN cord-005453-4057qib7 4228 30 < < XX cord-005453-4057qib7 4228 31 0.001 0.001 CD cord-005453-4057qib7 4228 32 ) ) -RRB- cord-005453-4057qib7 4228 33 and and CC cord-005453-4057qib7 4228 34 showed show VBD cord-005453-4057qib7 4228 35 most most RBS cord-005453-4057qib7 4228 36 frequently frequently RB cord-005453-4057qib7 4228 37 active active JJ cord-005453-4057qib7 4228 38 disease disease NN cord-005453-4057qib7 4228 39 at at IN cord-005453-4057qib7 4228 40 alloSCT alloSCT NNP cord-005453-4057qib7 4228 41 ( ( -LRB- cord-005453-4057qib7 4228 42 42 42 CD cord-005453-4057qib7 4228 43 % % NN cord-005453-4057qib7 4228 44 vs. vs. IN cord-005453-4057qib7 4228 45 18 18 CD cord-005453-4057qib7 4228 46 % % NN cord-005453-4057qib7 4228 47 , , , cord-005453-4057qib7 4228 48 p=0.002 p=0.002 NNP cord-005453-4057qib7 4228 49 ) ) -RRB- cord-005453-4057qib7 4228 50 . . . cord-005453-4057qib7 4229 1 In in IN cord-005453-4057qib7 4229 2 both both DT cord-005453-4057qib7 4229 3 groups group NNS cord-005453-4057qib7 4229 4 the the DT cord-005453-4057qib7 4229 5 most most RBS cord-005453-4057qib7 4229 6 frequent frequent JJ cord-005453-4057qib7 4229 7 graft graft NN cord-005453-4057qib7 4229 8 - - HYPH cord-005453-4057qib7 4229 9 versushost versushost NN cord-005453-4057qib7 4229 10 disease disease NN cord-005453-4057qib7 4229 11 ( ( -LRB- cord-005453-4057qib7 4229 12 GVHD GVHD NNP cord-005453-4057qib7 4229 13 ) ) -RRB- cord-005453-4057qib7 4229 14 prophylaxis prophylaxis NN cord-005453-4057qib7 4229 15 regimen regimen NN cord-005453-4057qib7 4229 16 was be VBD cord-005453-4057qib7 4229 17 cyclosporine cyclosporine JJ cord-005453-4057qib7 4229 18 A A NNP cord-005453-4057qib7 4229 19 and and CC cord-005453-4057qib7 4229 20 methotrexate methotrexate NNP cord-005453-4057qib7 4229 21 . . . cord-005453-4057qib7 4230 1 The the DT cord-005453-4057qib7 4230 2 median median JJ cord-005453-4057qib7 4230 3 follow follow NN cord-005453-4057qib7 4230 4 - - HYPH cord-005453-4057qib7 4230 5 up up RP cord-005453-4057qib7 4230 6 time time NN cord-005453-4057qib7 4230 7 was be VBD cord-005453-4057qib7 4230 8 2.3 2.3 CD cord-005453-4057qib7 4230 9 years year NNS cord-005453-4057qib7 4230 10 for for IN cord-005453-4057qib7 4230 11 the the DT cord-005453-4057qib7 4230 12 NMA NMA NNP cord-005453-4057qib7 4230 13 group group NN cord-005453-4057qib7 4230 14 and and CC cord-005453-4057qib7 4230 15 3.6 3.6 CD cord-005453-4057qib7 4230 16 years year NNS cord-005453-4057qib7 4230 17 for for IN cord-005453-4057qib7 4230 18 the the DT cord-005453-4057qib7 4230 19 MA MA NNP cord-005453-4057qib7 4230 20 group group NN cord-005453-4057qib7 4230 21 . . . cord-005453-4057qib7 4231 1 Patients patient NNS cord-005453-4057qib7 4231 2 from from IN cord-005453-4057qib7 4231 3 the the DT cord-005453-4057qib7 4231 4 MA MA NNP cord-005453-4057qib7 4231 5 group group NN cord-005453-4057qib7 4231 6 had have VBD cord-005453-4057qib7 4231 7 higher high JJR cord-005453-4057qib7 4231 8 incidence incidence NN cord-005453-4057qib7 4231 9 of of IN cord-005453-4057qib7 4231 10 grade grade NN cord-005453-4057qib7 4231 11 3 3 CD cord-005453-4057qib7 4231 12 - - SYM cord-005453-4057qib7 4231 13 4 4 CD cord-005453-4057qib7 4231 14 mucositis mucositis NNP cord-005453-4057qib7 4231 15 ( ( -LRB- cord-005453-4057qib7 4231 16 60 60 CD cord-005453-4057qib7 4231 17 % % NN cord-005453-4057qib7 4231 18 vs. vs. IN cord-005453-4057qib7 4231 19 22 22 CD cord-005453-4057qib7 4231 20 % % NN cord-005453-4057qib7 4231 21 , , , cord-005453-4057qib7 4231 22 p p NN cord-005453-4057qib7 4231 23 < < XX cord-005453-4057qib7 4231 24 0.001 0.001 CD cord-005453-4057qib7 4231 25 ) ) -RRB- cord-005453-4057qib7 4231 26 and and CC cord-005453-4057qib7 4231 27 acute acute JJ cord-005453-4057qib7 4231 28 GVHD GVHD NNP cord-005453-4057qib7 4231 29 of of IN cord-005453-4057qib7 4231 30 any any DT cord-005453-4057qib7 4231 31 grade grade NN cord-005453-4057qib7 4231 32 ( ( -LRB- cord-005453-4057qib7 4231 33 70 70 CD cord-005453-4057qib7 4231 34 % % NN cord-005453-4057qib7 4231 35 vs. vs. IN cord-005453-4057qib7 4231 36 53 53 CD cord-005453-4057qib7 4231 37 % % NN cord-005453-4057qib7 4231 38 , , , cord-005453-4057qib7 4231 39 p=0.029 p=0.029 NNP cord-005453-4057qib7 4231 40 ) ) -RRB- cord-005453-4057qib7 4231 41 than than IN cord-005453-4057qib7 4231 42 patients patient NNS cord-005453-4057qib7 4231 43 from from IN cord-005453-4057qib7 4231 44 the the DT cord-005453-4057qib7 4231 45 NMA NMA NNP cord-005453-4057qib7 4231 46 alloHSCT allohsct NN cord-005453-4057qib7 4231 47 . . . cord-005453-4057qib7 4232 1 The the DT cord-005453-4057qib7 4232 2 incidence incidence NN cord-005453-4057qib7 4232 3 of of IN cord-005453-4057qib7 4232 4 ARF ARF NNP cord-005453-4057qib7 4232 5 was be VBD cord-005453-4057qib7 4232 6 similar similar JJ cord-005453-4057qib7 4232 7 in in IN cord-005453-4057qib7 4232 8 both both DT cord-005453-4057qib7 4232 9 groups group NNS cord-005453-4057qib7 4232 10 ( ( -LRB- cord-005453-4057qib7 4232 11 72 72 CD cord-005453-4057qib7 4232 12 % % NN cord-005453-4057qib7 4232 13 in in IN cord-005453-4057qib7 4232 14 NMA NMA NNP cord-005453-4057qib7 4232 15 and and CC cord-005453-4057qib7 4232 16 71 71 CD cord-005453-4057qib7 4232 17 % % NN cord-005453-4057qib7 4232 18 in in IN cord-005453-4057qib7 4232 19 MA MA NNP cord-005453-4057qib7 4232 20 ) ) -RRB- cord-005453-4057qib7 4232 21 . . . cord-005453-4057qib7 4233 1 In in IN cord-005453-4057qib7 4233 2 the the DT cord-005453-4057qib7 4233 3 NMA NMA NNP cord-005453-4057qib7 4233 4 group group NN cord-005453-4057qib7 4233 5 arterial arterial JJ cord-005453-4057qib7 4233 6 hypertension hypertension NN cord-005453-4057qib7 4233 7 ( ( -LRB- cord-005453-4057qib7 4233 8 HR HR NNP cord-005453-4057qib7 4233 9 2.05 2.05 CD cord-005453-4057qib7 4233 10 , , , cord-005453-4057qib7 4233 11 p=0.018 p=0.018 NNP cord-005453-4057qib7 4233 12 ) ) -RRB- cord-005453-4057qib7 4233 13 , , , cord-005453-4057qib7 4233 14 obesity obesity NN cord-005453-4057qib7 4233 15 ( ( -LRB- cord-005453-4057qib7 4233 16 HR HR NNP cord-005453-4057qib7 4233 17 4.16 4.16 CD cord-005453-4057qib7 4233 18 , , , cord-005453-4057qib7 4233 19 p p NN cord-005453-4057qib7 4233 20 < < XX cord-005453-4057qib7 4233 21 0.001 0.001 CD cord-005453-4057qib7 4233 22 ) ) -RRB- cord-005453-4057qib7 4233 23 and and CC cord-005453-4057qib7 4233 24 prior prior JJ cord-005453-4057qib7 4233 25 pneumonia pneumonia NN cord-005453-4057qib7 4233 26 ( ( -LRB- cord-005453-4057qib7 4233 27 HR HR NNP cord-005453-4057qib7 4233 28 3.19 3.19 CD cord-005453-4057qib7 4233 29 , , , cord-005453-4057qib7 4233 30 < < XX cord-005453-4057qib7 4233 31 0.001 0.001 CD cord-005453-4057qib7 4233 32 ) ) -RRB- cord-005453-4057qib7 4233 33 were be VBD cord-005453-4057qib7 4233 34 predisposing predispose VBG cord-005453-4057qib7 4233 35 factors factor NNS cord-005453-4057qib7 4233 36 for for IN cord-005453-4057qib7 4233 37 ARF arf NN cord-005453-4057qib7 4233 38 by by IN cord-005453-4057qib7 4233 39 multivariate multivariate JJ cord-005453-4057qib7 4233 40 analysis analysis NN cord-005453-4057qib7 4233 41 , , , cord-005453-4057qib7 4233 42 whereas whereas IN cord-005453-4057qib7 4233 43 any any DT cord-005453-4057qib7 4233 44 factor factor NN cord-005453-4057qib7 4233 45 was be VBD cord-005453-4057qib7 4233 46 identified identify VBN cord-005453-4057qib7 4233 47 in in IN cord-005453-4057qib7 4233 48 the the DT cord-005453-4057qib7 4233 49 MA MA NNP cord-005453-4057qib7 4233 50 group group NN cord-005453-4057qib7 4233 51 . . . cord-005453-4057qib7 4234 1 ARF ARF NNP cord-005453-4057qib7 4234 2 had have VBD cord-005453-4057qib7 4234 3 no no DT cord-005453-4057qib7 4234 4 impact impact NN cord-005453-4057qib7 4234 5 on on IN cord-005453-4057qib7 4234 6 2-year 2-year CD cord-005453-4057qib7 4234 7 OS os NN cord-005453-4057qib7 4234 8 in in IN cord-005453-4057qib7 4234 9 both both DT cord-005453-4057qib7 4234 10 groups group NNS cord-005453-4057qib7 4234 11 ( ( -LRB- cord-005453-4057qib7 4234 12 28 28 CD cord-005453-4057qib7 4234 13 % % NN cord-005453-4057qib7 4234 14 vs. vs. CC cord-005453-4057qib7 4234 15 35 35 CD cord-005453-4057qib7 4234 16 % % NN cord-005453-4057qib7 4234 17 p=0.406 p=0.406 XX cord-005453-4057qib7 4235 1 for for IN cord-005453-4057qib7 4235 2 the the DT cord-005453-4057qib7 4235 3 NMA NMA NNP cord-005453-4057qib7 4235 4 group group NN cord-005453-4057qib7 4235 5 and and CC cord-005453-4057qib7 4235 6 45 45 CD cord-005453-4057qib7 4235 7 % % NN cord-005453-4057qib7 4235 8 vs. vs. IN cord-005453-4057qib7 4235 9 40 40 CD cord-005453-4057qib7 4235 10 % % NN cord-005453-4057qib7 4235 11 p=0.623 p=0.623 NNS cord-005453-4057qib7 4235 12 for for IN cord-005453-4057qib7 4235 13 the the DT cord-005453-4057qib7 4235 14 MA MA NNP cord-005453-4057qib7 4235 15 group group NN cord-005453-4057qib7 4235 16 ) ) -RRB- cord-005453-4057qib7 4235 17 . . . cord-005453-4057qib7 4236 1 However however RB cord-005453-4057qib7 4236 2 , , , cord-005453-4057qib7 4236 3 worse bad JJR cord-005453-4057qib7 4236 4 OS OS NNP cord-005453-4057qib7 4236 5 were be VBD cord-005453-4057qib7 4236 6 observed observe VBN cord-005453-4057qib7 4236 7 in in IN cord-005453-4057qib7 4236 8 patients patient NNS cord-005453-4057qib7 4236 9 with with IN cord-005453-4057qib7 4236 10 grade grade NN cord-005453-4057qib7 4236 11 2 2 CD cord-005453-4057qib7 4236 12 - - SYM cord-005453-4057qib7 4236 13 3 3 CD cord-005453-4057qib7 4236 14 ARF arf NN cord-005453-4057qib7 4236 15 in in IN cord-005453-4057qib7 4236 16 the the DT cord-005453-4057qib7 4236 17 NMA NMA NNP cord-005453-4057qib7 4236 18 group group NN cord-005453-4057qib7 4236 19 ( ( -LRB- cord-005453-4057qib7 4236 20 18 18 CD cord-005453-4057qib7 4236 21 % % NN cord-005453-4057qib7 4236 22 vs. vs. IN cord-005453-4057qib7 4236 23 43 43 CD cord-005453-4057qib7 4236 24 % % NN cord-005453-4057qib7 4236 25 , , , cord-005453-4057qib7 4236 26 p=0.048 p=0.048 NNP cord-005453-4057qib7 4236 27 ) ) -RRB- cord-005453-4057qib7 4236 28 and and CC cord-005453-4057qib7 4236 29 in in IN cord-005453-4057qib7 4236 30 patients patient NNS cord-005453-4057qib7 4236 31 with with IN cord-005453-4057qib7 4236 32 grade grade NN cord-005453-4057qib7 4236 33 3 3 CD cord-005453-4057qib7 4236 34 ARF arf NN cord-005453-4057qib7 4236 35 in in IN cord-005453-4057qib7 4236 36 the the DT cord-005453-4057qib7 4236 37 MA MA NNP cord-005453-4057qib7 4236 38 group group NN cord-005453-4057qib7 4236 39 ( ( -LRB- cord-005453-4057qib7 4236 40 25 25 CD cord-005453-4057qib7 4236 41 % % NN cord-005453-4057qib7 4236 42 vs. vs. IN cord-005453-4057qib7 4236 43 59 59 CD cord-005453-4057qib7 4236 44 % % NN cord-005453-4057qib7 4236 45 , , , cord-005453-4057qib7 4236 46 p=0.011 p=0.011 NNP cord-005453-4057qib7 4236 47 ) ) -RRB- cord-005453-4057qib7 4236 48 . . . cord-005453-4057qib7 4237 1 In in IN cord-005453-4057qib7 4237 2 turn turn NN cord-005453-4057qib7 4237 3 , , , cord-005453-4057qib7 4237 4 ARF ARF NNP cord-005453-4057qib7 4237 5 had have VBD cord-005453-4057qib7 4237 6 no no DT cord-005453-4057qib7 4237 7 influence influence NN cord-005453-4057qib7 4237 8 on on IN cord-005453-4057qib7 4237 9 NRM NRM NNP cord-005453-4057qib7 4237 10 in in IN cord-005453-4057qib7 4237 11 the the DT cord-005453-4057qib7 4237 12 MA MA NNP cord-005453-4057qib7 4237 13 group group NN cord-005453-4057qib7 4237 14 but but CC cord-005453-4057qib7 4237 15 was be VBD cord-005453-4057qib7 4237 16 associated associate VBN cord-005453-4057qib7 4237 17 with with IN cord-005453-4057qib7 4237 18 a a DT cord-005453-4057qib7 4237 19 trend trend NN cord-005453-4057qib7 4237 20 for for IN cord-005453-4057qib7 4237 21 higher high JJR cord-005453-4057qib7 4237 22 NRM NRM NNP cord-005453-4057qib7 4237 23 in in IN cord-005453-4057qib7 4237 24 the the DT cord-005453-4057qib7 4237 25 NMA NMA NNP cord-005453-4057qib7 4237 26 group group NN cord-005453-4057qib7 4237 27 ( ( -LRB- cord-005453-4057qib7 4237 28 59 59 CD cord-005453-4057qib7 4237 29 % % NN cord-005453-4057qib7 4237 30 vs. vs. CC cord-005453-4057qib7 4237 31 35 35 CD cord-005453-4057qib7 4237 32 % % NN cord-005453-4057qib7 4237 33 , , , cord-005453-4057qib7 4237 34 p=0.084 p=0.084 NNP cord-005453-4057qib7 4237 35 ) ) -RRB- cord-005453-4057qib7 4237 36 . . . cord-005453-4057qib7 4238 1 Conclusions conclusion NNS cord-005453-4057qib7 4238 2 : : : cord-005453-4057qib7 4238 3 ARF ARF NNP cord-005453-4057qib7 4238 4 is be VBZ cord-005453-4057qib7 4238 5 a a DT cord-005453-4057qib7 4238 6 frequent frequent JJ cord-005453-4057qib7 4238 7 complication complication NN cord-005453-4057qib7 4238 8 in in IN cord-005453-4057qib7 4238 9 patients patient NNS cord-005453-4057qib7 4238 10 receiving receive VBG cord-005453-4057qib7 4238 11 alloHSCT alloHSCT NNP cord-005453-4057qib7 4238 12 irrespective irrespective RB cord-005453-4057qib7 4238 13 of of IN cord-005453-4057qib7 4238 14 the the DT cord-005453-4057qib7 4238 15 intensity intensity NN cord-005453-4057qib7 4238 16 of of IN cord-005453-4057qib7 4238 17 the the DT cord-005453-4057qib7 4238 18 conditioning conditioning NN cord-005453-4057qib7 4238 19 regimen regimen NN cord-005453-4057qib7 4238 20 . . . cord-005453-4057qib7 4239 1 Moderate moderate JJ cord-005453-4057qib7 4239 2 and and CC cord-005453-4057qib7 4239 3 severe severe JJ cord-005453-4057qib7 4239 4 ARF arf NN cord-005453-4057qib7 4239 5 had have VBD cord-005453-4057qib7 4239 6 negative negative JJ cord-005453-4057qib7 4239 7 impact impact NN cord-005453-4057qib7 4239 8 on on IN cord-005453-4057qib7 4239 9 OS OS NNP cord-005453-4057qib7 4239 10 . . . cord-005453-4057qib7 4240 1 Disclosure disclosure NN cord-005453-4057qib7 4240 2 : : : cord-005453-4057qib7 4240 3 Supported support VBN cord-005453-4057qib7 4240 4 by by IN cord-005453-4057qib7 4240 5 grants grant NNS cord-005453-4057qib7 4240 6 from from IN cord-005453-4057qib7 4240 7 : : : cord-005453-4057qib7 4240 8 Asociación Asociación NNP cord-005453-4057qib7 4240 9 Española Española NNP cord-005453-4057qib7 4240 10 Contra Contra NNP cord-005453-4057qib7 4240 11 el el NNP cord-005453-4057qib7 4240 12 Cáncer Cáncer NNP cord-005453-4057qib7 4240 13 , , , cord-005453-4057qib7 4240 14 AECC AECC NNP cord-005453-4057qib7 4240 15 ( ( -LRB- cord-005453-4057qib7 4240 16 GC16173697BIGA GC16173697BIGA NNP cord-005453-4057qib7 4240 17 ) ) -RRB- cord-005453-4057qib7 4240 18 , , , cord-005453-4057qib7 4240 19 Instituto Instituto NNP cord-005453-4057qib7 4240 20 Carlos Carlos NNP cord-005453-4057qib7 4240 21 III III NNP cord-005453-4057qib7 4240 22 ( ( -LRB- cord-005453-4057qib7 4240 23 PI14/01971 PI14/01971 NNP cord-005453-4057qib7 4240 24 FI FI NNP cord-005453-4057qib7 4240 25 ) ) -RRB- cord-005453-4057qib7 4240 26 , , , cord-005453-4057qib7 4240 27 2017-SGR288 2017-sgr288 CD cord-005453-4057qib7 4240 28 ( ( -LRB- cord-005453-4057qib7 4240 29 GRC GRC NNP cord-005453-4057qib7 4240 30 ) ) -RRB- cord-005453-4057qib7 4240 31 , , . cord-005453-4057qib7 4241 1 CERCA CERCA NNP cord-005453-4057qib7 4241 2 Program Program NNP cord-005453-4057qib7 4241 3 from from IN cord-005453-4057qib7 4241 4 Generalitat Generalitat NNP cord-005453-4057qib7 4241 5 de de NNP cord-005453-4057qib7 4241 6 Catalunya Catalunya NNP cord-005453-4057qib7 4241 7 , , , cord-005453-4057qib7 4241 8 and and CC cord-005453-4057qib7 4241 9 " " `` cord-005453-4057qib7 4241 10 La La NNP cord-005453-4057qib7 4241 11 Caixa Caixa NNP cord-005453-4057qib7 4241 12 " " '' cord-005453-4057qib7 4241 13 Foundation Foundation NNP cord-005453-4057qib7 4241 14 . . . cord-005453-4057qib7 4242 1 Treatment treatment NN cord-005453-4057qib7 4242 2 and and CC cord-005453-4057qib7 4242 3 risk risk NN cord-005453-4057qib7 4242 4 factors factor NNS cord-005453-4057qib7 4242 5 of of IN cord-005453-4057qib7 4242 6 hepatic hepatic JJ cord-005453-4057qib7 4242 7 veno veno NN cord-005453-4057qib7 4242 8 - - HYPH cord-005453-4057qib7 4242 9 occlusive occlusive JJ cord-005453-4057qib7 4242 10 disease disease NN cord-005453-4057qib7 4242 11 after after IN cord-005453-4057qib7 4242 12 pediatric pediatric JJ cord-005453-4057qib7 4242 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 4242 14 stem stem NN cord-005453-4057qib7 4242 15 cell cell NN cord-005453-4057qib7 4242 16 transplantation transplantation NN cord-005453-4057qib7 4242 17 : : : cord-005453-4057qib7 4242 18 A a DT cord-005453-4057qib7 4242 19 single single JJ cord-005453-4057qib7 4242 20 - - HYPH cord-005453-4057qib7 4242 21 center center NN cord-005453-4057qib7 4242 22 experience experience NN cord-005453-4057qib7 4242 23 Barbaros Barbaros NNP cord-005453-4057qib7 4242 24 Sahin Sahin NNP cord-005453-4057qib7 4242 25 Karagün Karagün NNP cord-005453-4057qib7 4242 26 1 1 CD cord-005453-4057qib7 4242 27 , , , cord-005453-4057qib7 4242 28 Ilgen Ilgen NNP cord-005453-4057qib7 4242 29 Sasmaz Sasmaz NNP cord-005453-4057qib7 4242 30 2 2 CD cord-005453-4057qib7 4242 31 , , , cord-005453-4057qib7 4242 32 Ali Ali NNP cord-005453-4057qib7 4242 33 Bülent Bülent NNP cord-005453-4057qib7 4243 1 Antmen Antmen NNP cord-005453-4057qib7 4243 2 1 1 CD cord-005453-4057qib7 4243 3 Background Background NNP cord-005453-4057qib7 4243 4 : : : cord-005453-4057qib7 4243 5 Defibrotide Defibrotide NNP cord-005453-4057qib7 4243 6 emerged emerge VBD cord-005453-4057qib7 4243 7 as as IN cord-005453-4057qib7 4243 8 a a DT cord-005453-4057qib7 4243 9 promising promising JJ cord-005453-4057qib7 4243 10 treatment treatment NN cord-005453-4057qib7 4243 11 option option NN cord-005453-4057qib7 4243 12 for for IN cord-005453-4057qib7 4243 13 hepatic hepatic JJ cord-005453-4057qib7 4243 14 veno veno NNP cord-005453-4057qib7 4243 15 - - HYPH cord-005453-4057qib7 4243 16 occlusive occlusive JJ cord-005453-4057qib7 4243 17 disease disease NN cord-005453-4057qib7 4243 18 , , , cord-005453-4057qib7 4243 19 a a DT cord-005453-4057qib7 4243 20 significant significant JJ cord-005453-4057qib7 4243 21 cause cause NN cord-005453-4057qib7 4243 22 of of IN cord-005453-4057qib7 4243 23 mortality mortality NN cord-005453-4057qib7 4243 24 in in IN cord-005453-4057qib7 4243 25 recipients recipient NNS cord-005453-4057qib7 4243 26 of of IN cord-005453-4057qib7 4243 27 HSCT HSCT NNP cord-005453-4057qib7 4243 28 . . . cord-005453-4057qib7 4244 1 As as IN cord-005453-4057qib7 4244 2 VOD VOD NNP cord-005453-4057qib7 4244 3 diagnosis diagnosis NN cord-005453-4057qib7 4244 4 is be VBZ cord-005453-4057qib7 4244 5 quite quite RB cord-005453-4057qib7 4244 6 difficult difficult JJ cord-005453-4057qib7 4244 7 even even RB cord-005453-4057qib7 4244 8 with with IN cord-005453-4057qib7 4244 9 the the DT cord-005453-4057qib7 4244 10 recently recently RB cord-005453-4057qib7 4244 11 introduced introduce VBN cord-005453-4057qib7 4244 12 EBMT EBMT NNP cord-005453-4057qib7 4244 13 2017 2017 CD cord-005453-4057qib7 4244 14 criteria criterion NNS cord-005453-4057qib7 4244 15 , , , cord-005453-4057qib7 4244 16 studies study NNS cord-005453-4057qib7 4244 17 which which WDT cord-005453-4057qib7 4244 18 report report VBP cord-005453-4057qib7 4244 19 treatment treatment NN cord-005453-4057qib7 4244 20 outcomes outcome NNS cord-005453-4057qib7 4244 21 and and CC cord-005453-4057qib7 4244 22 response response NN cord-005453-4057qib7 4244 23 to to IN cord-005453-4057qib7 4244 24 prophylaxis prophylaxis NN cord-005453-4057qib7 4244 25 are be VBP cord-005453-4057qib7 4244 26 required require VBN cord-005453-4057qib7 4244 27 . . . cord-005453-4057qib7 4245 1 Our -PRON- PRP$ cord-005453-4057qib7 4245 2 aim aim NN cord-005453-4057qib7 4245 3 was be VBD cord-005453-4057qib7 4245 4 to to TO cord-005453-4057qib7 4245 5 evaluate evaluate VB cord-005453-4057qib7 4245 6 the the DT cord-005453-4057qib7 4245 7 efficacy efficacy NN cord-005453-4057qib7 4245 8 of of IN cord-005453-4057qib7 4245 9 defibrotide defibrotide NN cord-005453-4057qib7 4245 10 prophylaxis prophylaxis NN cord-005453-4057qib7 4245 11 in in IN cord-005453-4057qib7 4245 12 HSCT HSCT NNP cord-005453-4057qib7 4245 13 recipients recipient NNS cord-005453-4057qib7 4245 14 at at IN cord-005453-4057qib7 4245 15 our -PRON- PRP$ cord-005453-4057qib7 4245 16 center center NN cord-005453-4057qib7 4245 17 . . . cord-005453-4057qib7 4246 1 Methods method NNS cord-005453-4057qib7 4246 2 : : : cord-005453-4057qib7 4246 3 A a DT cord-005453-4057qib7 4246 4 total total NN cord-005453-4057qib7 4246 5 of of IN cord-005453-4057qib7 4246 6 236 236 CD cord-005453-4057qib7 4246 7 transplants transplant NNS cord-005453-4057qib7 4246 8 in in IN cord-005453-4057qib7 4246 9 210 210 CD cord-005453-4057qib7 4246 10 patients patient NNS cord-005453-4057qib7 4246 11 from from IN cord-005453-4057qib7 4246 12 January January NNP cord-005453-4057qib7 4246 13 2013 2013 CD cord-005453-4057qib7 4246 14 to to IN cord-005453-4057qib7 4246 15 July July NNP cord-005453-4057qib7 4246 16 2018 2018 CD cord-005453-4057qib7 4246 17 were be VBD cord-005453-4057qib7 4246 18 included include VBN cord-005453-4057qib7 4246 19 in in IN cord-005453-4057qib7 4246 20 this this DT cord-005453-4057qib7 4246 21 study study NN cord-005453-4057qib7 4246 22 . . . cord-005453-4057qib7 4247 1 All all DT cord-005453-4057qib7 4247 2 patients patient NNS cord-005453-4057qib7 4247 3 had have VBD cord-005453-4057qib7 4247 4 factors factor NNS cord-005453-4057qib7 4247 5 that that WDT cord-005453-4057qib7 4247 6 increased increase VBD cord-005453-4057qib7 4247 7 the the DT cord-005453-4057qib7 4247 8 risk risk NN cord-005453-4057qib7 4247 9 of of IN cord-005453-4057qib7 4247 10 VOD VOD NNP cord-005453-4057qib7 4247 11 and and CC cord-005453-4057qib7 4247 12 all all DT cord-005453-4057qib7 4247 13 received receive VBD cord-005453-4057qib7 4247 14 25 25 CD cord-005453-4057qib7 4247 15 mg mg NNP cord-005453-4057qib7 4247 16 / / SYM cord-005453-4057qib7 4247 17 kg kg NNP cord-005453-4057qib7 4247 18 / / SYM cord-005453-4057qib7 4247 19 day day NN cord-005453-4057qib7 4247 20 prophylaxis prophylaxis NN cord-005453-4057qib7 4247 21 . . . cord-005453-4057qib7 4248 1 Patients patient NNS cord-005453-4057qib7 4248 2 ' ' POS cord-005453-4057qib7 4248 3 coagulation coagulation NN cord-005453-4057qib7 4248 4 , , , cord-005453-4057qib7 4248 5 renal renal JJ cord-005453-4057qib7 4248 6 and and CC cord-005453-4057qib7 4248 7 liver liver NN cord-005453-4057qib7 4248 8 function function NN cord-005453-4057qib7 4248 9 test test NN cord-005453-4057qib7 4248 10 were be VBD cord-005453-4057qib7 4248 11 monitored monitor VBN cord-005453-4057qib7 4248 12 daily daily RB cord-005453-4057qib7 4248 13 and and CC cord-005453-4057qib7 4248 14 all all DT cord-005453-4057qib7 4248 15 clinical clinical JJ cord-005453-4057qib7 4248 16 findings finding NNS cord-005453-4057qib7 4248 17 and and CC cord-005453-4057qib7 4248 18 complaints complaint NNS cord-005453-4057qib7 4248 19 were be VBD cord-005453-4057qib7 4248 20 recorded record VBN cord-005453-4057qib7 4248 21 . . . cord-005453-4057qib7 4249 1 Diagnoses diagnosis NNS cord-005453-4057qib7 4249 2 were be VBD cord-005453-4057qib7 4249 3 made make VBN cord-005453-4057qib7 4249 4 via via IN cord-005453-4057qib7 4249 5 the the DT cord-005453-4057qib7 4249 6 EBMT EBMT NNP cord-005453-4057qib7 4249 7 2017 2017 CD cord-005453-4057qib7 4249 8 VOD VOD NNP cord-005453-4057qib7 4249 9 criteria criterion NNS cord-005453-4057qib7 4249 10 and and CC cord-005453-4057qib7 4249 11 patients patient NNS cord-005453-4057qib7 4249 12 who who WP cord-005453-4057qib7 4249 13 developed develop VBD cord-005453-4057qib7 4249 14 VOD VOD NNP cord-005453-4057qib7 4249 15 received receive VBD cord-005453-4057qib7 4249 16 treatment treatment NN cord-005453-4057qib7 4249 17 with with IN cord-005453-4057qib7 4249 18 increased increase VBN cord-005453-4057qib7 4249 19 DF DF NNP cord-005453-4057qib7 4249 20 dose dose NN cord-005453-4057qib7 4249 21 ( ( -LRB- cord-005453-4057qib7 4249 22 40 40 CD cord-005453-4057qib7 4249 23 mg mg NNP cord-005453-4057qib7 4249 24 / / SYM cord-005453-4057qib7 4249 25 kg kg NNP cord-005453-4057qib7 4249 26 / / SYM cord-005453-4057qib7 4249 27 day day NN cord-005453-4057qib7 4249 28 ) ) -RRB- cord-005453-4057qib7 4249 29 and and CC cord-005453-4057qib7 4249 30 supportive supportive JJ cord-005453-4057qib7 4249 31 interventions intervention NNS cord-005453-4057qib7 4249 32 . . . cord-005453-4057qib7 4250 1 After after IN cord-005453-4057qib7 4250 2 complete complete JJ cord-005453-4057qib7 4250 3 remission remission NN cord-005453-4057qib7 4250 4 of of IN cord-005453-4057qib7 4250 5 VOD VOD NNP cord-005453-4057qib7 4250 6 findings finding NNS cord-005453-4057qib7 4250 7 , , , cord-005453-4057qib7 4250 8 patients patient NNS cord-005453-4057qib7 4250 9 were be VBD cord-005453-4057qib7 4250 10 returned return VBN cord-005453-4057qib7 4250 11 to to IN cord-005453-4057qib7 4250 12 the the DT cord-005453-4057qib7 4250 13 prophylaxis prophylaxis NN cord-005453-4057qib7 4250 14 dose dose NN cord-005453-4057qib7 4250 15 . . . cord-005453-4057qib7 4251 1 Close close JJ cord-005453-4057qib7 4251 2 follow follow NN cord-005453-4057qib7 4251 3 - - HYPH cord-005453-4057qib7 4251 4 up up NN cord-005453-4057qib7 4251 5 of of IN cord-005453-4057qib7 4251 6 patients patient NNS cord-005453-4057qib7 4251 7 was be VBD cord-005453-4057qib7 4251 8 performed perform VBN cord-005453-4057qib7 4251 9 until until IN cord-005453-4057qib7 4251 10 100 100 CD cord-005453-4057qib7 4251 11 days day NNS cord-005453-4057qib7 4251 12 . . . cord-005453-4057qib7 4252 1 Results result NNS cord-005453-4057qib7 4252 2 : : : cord-005453-4057qib7 4253 1 In in IN cord-005453-4057qib7 4253 2 total total NN cord-005453-4057qib7 4253 3 , , , cord-005453-4057qib7 4253 4 17 17 CD cord-005453-4057qib7 4253 5 patients patient NNS cord-005453-4057qib7 4253 6 developed develop VBD cord-005453-4057qib7 4253 7 VOD VOD NNP cord-005453-4057qib7 4253 8 ( ( -LRB- cord-005453-4057qib7 4253 9 7.2 7.2 CD cord-005453-4057qib7 4253 10 % % NN cord-005453-4057qib7 4253 11 ) ) -RRB- cord-005453-4057qib7 4253 12 , , , cord-005453-4057qib7 4253 13 none none NN cord-005453-4057qib7 4253 14 of of IN cord-005453-4057qib7 4253 15 the the DT cord-005453-4057qib7 4253 16 cases case NNS cord-005453-4057qib7 4253 17 were be VBD cord-005453-4057qib7 4253 18 severe severe JJ cord-005453-4057qib7 4253 19 ( ( -LRB- cord-005453-4057qib7 4253 20 13 13 CD cord-005453-4057qib7 4253 21 mild mild JJ cord-005453-4057qib7 4253 22 , , , cord-005453-4057qib7 4253 23 4 4 CD cord-005453-4057qib7 4253 24 moderate moderate JJ cord-005453-4057qib7 4253 25 ) ) -RRB- cord-005453-4057qib7 4253 26 . . . cord-005453-4057qib7 4254 1 Median median JJ cord-005453-4057qib7 4254 2 age age NN cord-005453-4057qib7 4254 3 was be VBD cord-005453-4057qib7 4254 4 8.5 8.5 CD cord-005453-4057qib7 4254 5 years year NNS cord-005453-4057qib7 4254 6 and and CC cord-005453-4057qib7 4254 7 the the DT cord-005453-4057qib7 4254 8 most most RBS cord-005453-4057qib7 4254 9 common common JJ cord-005453-4057qib7 4254 10 clinical clinical JJ cord-005453-4057qib7 4254 11 findings finding NNS cord-005453-4057qib7 4254 12 were be VBD cord-005453-4057qib7 4254 13 weight weight NN cord-005453-4057qib7 4254 14 increase increase NN cord-005453-4057qib7 4254 15 , , , cord-005453-4057qib7 4254 16 hepatomegaly hepatomegaly NNP cord-005453-4057qib7 4254 17 , , , cord-005453-4057qib7 4254 18 right right JJ cord-005453-4057qib7 4254 19 upper upper JJ cord-005453-4057qib7 4254 20 quadrant quadrant JJ cord-005453-4057qib7 4254 21 pain pain NN cord-005453-4057qib7 4254 22 and and CC cord-005453-4057qib7 4254 23 ascites ascites NN cord-005453-4057qib7 4254 24 development development NN cord-005453-4057qib7 4254 25 . . . cord-005453-4057qib7 4255 1 In in IN cord-005453-4057qib7 4255 2 those those DT cord-005453-4057qib7 4255 3 with with IN cord-005453-4057qib7 4255 4 VOD VOD NNP cord-005453-4057qib7 4255 5 , , , cord-005453-4057qib7 4255 6 treatment treatment NN cord-005453-4057qib7 4255 7 with with IN cord-005453-4057qib7 4255 8 40 40 CD cord-005453-4057qib7 4255 9 mg mg NNP cord-005453-4057qib7 4255 10 / / SYM cord-005453-4057qib7 4255 11 kg kg NNP cord-005453-4057qib7 4255 12 / / SYM cord-005453-4057qib7 4255 13 day day NN cord-005453-4057qib7 4255 14 DF DF NNP cord-005453-4057qib7 4255 15 was be VBD cord-005453-4057qib7 4255 16 initiated initiate VBN cord-005453-4057qib7 4255 17 and and CC cord-005453-4057qib7 4255 18 average average JJ cord-005453-4057qib7 4255 19 duration duration NN cord-005453-4057qib7 4255 20 of of IN cord-005453-4057qib7 4255 21 treatment treatment NN cord-005453-4057qib7 4255 22 with with IN cord-005453-4057qib7 4255 23 this this DT cord-005453-4057qib7 4255 24 dosage dosage NN cord-005453-4057qib7 4255 25 was be VBD cord-005453-4057qib7 4255 26 7.4 7.4 CD cord-005453-4057qib7 4255 27 ( ( -LRB- cord-005453-4057qib7 4255 28 5 5 CD cord-005453-4057qib7 4255 29 - - SYM cord-005453-4057qib7 4255 30 11 11 CD cord-005453-4057qib7 4255 31 ) ) -RRB- cord-005453-4057qib7 4255 32 days day NNS cord-005453-4057qib7 4255 33 . . . cord-005453-4057qib7 4256 1 No no DT cord-005453-4057qib7 4256 2 adverse adverse JJ cord-005453-4057qib7 4256 3 events event NNS cord-005453-4057qib7 4256 4 were be VBD cord-005453-4057qib7 4256 5 reported report VBN cord-005453-4057qib7 4256 6 in in IN cord-005453-4057qib7 4256 7 any any DT cord-005453-4057qib7 4256 8 of of IN cord-005453-4057qib7 4256 9 the the DT cord-005453-4057qib7 4256 10 patients patient NNS cord-005453-4057qib7 4256 11 . . . cord-005453-4057qib7 4257 1 Conclusions conclusion NNS cord-005453-4057qib7 4257 2 : : : cord-005453-4057qib7 4258 1 Our -PRON- PRP$ cord-005453-4057qib7 4258 2 findings finding NNS cord-005453-4057qib7 4258 3 are be VBP cord-005453-4057qib7 4258 4 consistent consistent JJ cord-005453-4057qib7 4258 5 with with IN cord-005453-4057qib7 4258 6 previous previous JJ cord-005453-4057qib7 4258 7 studies study NNS cord-005453-4057qib7 4258 8 on on IN cord-005453-4057qib7 4258 9 this this DT cord-005453-4057qib7 4258 10 topic topic NN cord-005453-4057qib7 4258 11 , , , cord-005453-4057qib7 4258 12 and and CC cord-005453-4057qib7 4258 13 we -PRON- PRP cord-005453-4057qib7 4258 14 believe believe VBP cord-005453-4057qib7 4258 15 that that IN cord-005453-4057qib7 4258 16 the the DT cord-005453-4057qib7 4258 17 use use NN cord-005453-4057qib7 4258 18 of of IN cord-005453-4057qib7 4258 19 DF DF NNP cord-005453-4057qib7 4258 20 as as IN cord-005453-4057qib7 4258 21 a a DT cord-005453-4057qib7 4258 22 prophylactic prophylactic JJ cord-005453-4057qib7 4258 23 agent agent NN cord-005453-4057qib7 4258 24 for for IN cord-005453-4057qib7 4258 25 VOD VOD NNP cord-005453-4057qib7 4258 26 is be VBZ cord-005453-4057qib7 4258 27 beneficial beneficial JJ cord-005453-4057qib7 4258 28 for for IN cord-005453-4057qib7 4258 29 pediatric pediatric JJ cord-005453-4057qib7 4258 30 patients patient NNS cord-005453-4057qib7 4258 31 with with IN cord-005453-4057qib7 4258 32 risk risk NN cord-005453-4057qib7 4258 33 factors factor NNS cord-005453-4057qib7 4258 34 . . . cord-005453-4057qib7 4259 1 Disclosure disclosure NN cord-005453-4057qib7 4259 2 : : : cord-005453-4057qib7 4260 1 The the DT cord-005453-4057qib7 4260 2 authors author NNS cord-005453-4057qib7 4260 3 report report VBP cord-005453-4057qib7 4260 4 no no DT cord-005453-4057qib7 4260 5 conflicts conflict NNS cord-005453-4057qib7 4260 6 of of IN cord-005453-4057qib7 4260 7 interest interest NN cord-005453-4057qib7 4260 8 in in IN cord-005453-4057qib7 4260 9 this this DT cord-005453-4057qib7 4260 10 work work NN cord-005453-4057qib7 4260 11 . . . cord-005453-4057qib7 4261 1 Background background NN cord-005453-4057qib7 4261 2 : : : cord-005453-4057qib7 4262 1 Several several JJ cord-005453-4057qib7 4262 2 factors factor NNS cord-005453-4057qib7 4262 3 might may MD cord-005453-4057qib7 4262 4 influence influence VB cord-005453-4057qib7 4262 5 outcome outcome NN cord-005453-4057qib7 4262 6 of of IN cord-005453-4057qib7 4262 7 allo allo NN cord-005453-4057qib7 4262 8 - - HYPH cord-005453-4057qib7 4262 9 HSCT HSCT NNP cord-005453-4057qib7 4262 10 . . . cord-005453-4057qib7 4263 1 Analysis analysis NN cord-005453-4057qib7 4263 2 of of IN cord-005453-4057qib7 4263 3 the the DT cord-005453-4057qib7 4263 4 impact impact NN cord-005453-4057qib7 4263 5 of of IN cord-005453-4057qib7 4263 6 donor donor NN cord-005453-4057qib7 4263 7 - - HYPH cord-005453-4057qib7 4263 8 receptor receptor NN cord-005453-4057qib7 4263 9 blood blood NN cord-005453-4057qib7 4263 10 group group NN cord-005453-4057qib7 4263 11 - - HYPH cord-005453-4057qib7 4263 12 incompatibility incompatibility NN cord-005453-4057qib7 4263 13 have have VBP cord-005453-4057qib7 4263 14 been be VBN cord-005453-4057qib7 4263 15 performed perform VBN cord-005453-4057qib7 4263 16 in in IN cord-005453-4057qib7 4263 17 different different JJ cord-005453-4057qib7 4263 18 series series NN cord-005453-4057qib7 4263 19 not not RB cord-005453-4057qib7 4263 20 always always RB cord-005453-4057qib7 4263 21 showing show VBG cord-005453-4057qib7 4263 22 the the DT cord-005453-4057qib7 4263 23 same same JJ cord-005453-4057qib7 4263 24 results result NNS cord-005453-4057qib7 4263 25 . . . cord-005453-4057qib7 4264 1 As as IN cord-005453-4057qib7 4264 2 a a DT cord-005453-4057qib7 4264 3 consequence consequence NN cord-005453-4057qib7 4264 4 , , , cord-005453-4057qib7 4264 5 its -PRON- PRP$ cord-005453-4057qib7 4264 6 clinical clinical JJ cord-005453-4057qib7 4264 7 impact impact NN cord-005453-4057qib7 4264 8 remains remain VBZ cord-005453-4057qib7 4264 9 controversial controversial JJ cord-005453-4057qib7 4264 10 . . . cord-005453-4057qib7 4265 1 Minormismatch Minormismatch NNP cord-005453-4057qib7 4265 2 is be VBZ cord-005453-4057qib7 4265 3 characterized characterize VBN cord-005453-4057qib7 4265 4 by by IN cord-005453-4057qib7 4265 5 the the DT cord-005453-4057qib7 4265 6 ability ability NN cord-005453-4057qib7 4265 7 of of IN cord-005453-4057qib7 4265 8 donor donor NN cord-005453-4057qib7 4265 9 B b NN cord-005453-4057qib7 4265 10 lymphocytes lymphocyte NNS cord-005453-4057qib7 4265 11 to to TO cord-005453-4057qib7 4265 12 produce produce VB cord-005453-4057qib7 4265 13 anti anti JJ cord-005453-4057qib7 4265 14 - - JJ cord-005453-4057qib7 4265 15 recipient recipient JJ cord-005453-4057qib7 4265 16 antibodies antibody NNS cord-005453-4057qib7 4265 17 . . . cord-005453-4057qib7 4266 1 In in IN cord-005453-4057qib7 4266 2 majormismatch majormismatch NN cord-005453-4057qib7 4266 3 cases case NNS cord-005453-4057qib7 4266 4 , , , cord-005453-4057qib7 4266 5 antibodies antibody NNS cord-005453-4057qib7 4266 6 against against IN cord-005453-4057qib7 4266 7 donor donor NN cord-005453-4057qib7 4266 8 antigens antigen NNS cord-005453-4057qib7 4266 9 are be VBP cord-005453-4057qib7 4266 10 present present JJ cord-005453-4057qib7 4266 11 in in IN cord-005453-4057qib7 4266 12 the the DT cord-005453-4057qib7 4266 13 recipient recipient NN cord-005453-4057qib7 4266 14 . . . cord-005453-4057qib7 4267 1 Methods method NNS cord-005453-4057qib7 4267 2 : : : cord-005453-4057qib7 4268 1 343 343 CD cord-005453-4057qib7 4268 2 pts pt NNS cord-005453-4057qib7 4268 3 underwent undergo VBD cord-005453-4057qib7 4268 4 allo allo NN cord-005453-4057qib7 4268 5 - - HYPH cord-005453-4057qib7 4268 6 HSCT HSCT NNP cord-005453-4057qib7 4268 7 between between IN cord-005453-4057qib7 4268 8 May May NNP cord-005453-4057qib7 4268 9 2011 2011 CD cord-005453-4057qib7 4268 10 and and CC cord-005453-4057qib7 4268 11 August August NNP cord-005453-4057qib7 4268 12 2018 2018 CD cord-005453-4057qib7 4268 13 in in IN cord-005453-4057qib7 4268 14 our -PRON- PRP$ cord-005453-4057qib7 4268 15 center center NN cord-005453-4057qib7 4268 16 . . . cord-005453-4057qib7 4269 1 Median median JJ cord-005453-4057qib7 4269 2 age age NN cord-005453-4057qib7 4269 3 was be VBD cord-005453-4057qib7 4269 4 52 52 CD cord-005453-4057qib7 4269 5 years year NNS cord-005453-4057qib7 4270 1 ( ( -LRB- cord-005453-4057qib7 4270 2 range range NN cord-005453-4057qib7 4270 3 : : : cord-005453-4057qib7 4270 4 7 7 CD cord-005453-4057qib7 4270 5 - - SYM cord-005453-4057qib7 4270 6 69 69 CD cord-005453-4057qib7 4270 7 ) ) -RRB- cord-005453-4057qib7 4270 8 . . . cord-005453-4057qib7 4271 1 193 193 CD cord-005453-4057qib7 4271 2 pts pt NNS cord-005453-4057qib7 4271 3 were be VBD cord-005453-4057qib7 4271 4 male male JJ cord-005453-4057qib7 4271 5 ( ( -LRB- cord-005453-4057qib7 4271 6 56.3 56.3 CD cord-005453-4057qib7 4271 7 % % NN cord-005453-4057qib7 4271 8 ) ) -RRB- cord-005453-4057qib7 4271 9 and and CC cord-005453-4057qib7 4271 10 150 150 CD cord-005453-4057qib7 4271 11 female female JJ cord-005453-4057qib7 4271 12 ( ( -LRB- cord-005453-4057qib7 4271 13 43.7 43.7 CD cord-005453-4057qib7 4271 14 % % NN cord-005453-4057qib7 4271 15 ) ) -RRB- cord-005453-4057qib7 4271 16 . . . cord-005453-4057qib7 4272 1 Baseline baseline JJ cord-005453-4057qib7 4272 2 diseases disease NNS cord-005453-4057qib7 4272 3 were be VBD cord-005453-4057qib7 4272 4 : : : cord-005453-4057qib7 4272 5 138 138 CD cord-005453-4057qib7 4272 6 AML AML NNP cord-005453-4057qib7 4272 7 , , , cord-005453-4057qib7 4272 8 76 76 CD cord-005453-4057qib7 4272 9 LPD LPD NNP cord-005453-4057qib7 4272 10 , , , cord-005453-4057qib7 4272 11 44 44 CD cord-005453-4057qib7 4272 12 MDS MDS NNP cord-005453-4057qib7 4272 13 , , , cord-005453-4057qib7 4272 14 41 41 CD cord-005453-4057qib7 4272 15 ALL all DT cord-005453-4057qib7 4272 16 , , , cord-005453-4057qib7 4272 17 21 21 CD cord-005453-4057qib7 4272 18 MPD MPD NNP cord-005453-4057qib7 4272 19 , , , cord-005453-4057qib7 4272 20 16 16 CD cord-005453-4057qib7 4272 21 MM MM NNP cord-005453-4057qib7 4272 22 , , , cord-005453-4057qib7 4272 23 and and CC cord-005453-4057qib7 4272 24 7 7 CD cord-005453-4057qib7 4272 25 BMF bmf NN cord-005453-4057qib7 4272 26 . . . cord-005453-4057qib7 4273 1 Donor donor NN cord-005453-4057qib7 4273 2 was be VBD cord-005453-4057qib7 4273 3 unrelated unrelated JJ cord-005453-4057qib7 4273 4 in in IN cord-005453-4057qib7 4273 5 191 191 CD cord-005453-4057qib7 4273 6 , , , cord-005453-4057qib7 4273 7 and and CC cord-005453-4057qib7 4273 8 related relate VBN cord-005453-4057qib7 4273 9 in in IN cord-005453-4057qib7 4273 10 152 152 CD cord-005453-4057qib7 4273 11 cases case NNS cord-005453-4057qib7 4273 12 ( ( -LRB- cord-005453-4057qib7 4273 13 including include VBG cord-005453-4057qib7 4273 14 36 36 CD cord-005453-4057qib7 4273 15 haplo haplo NN cord-005453-4057qib7 4273 16 - - HYPH cord-005453-4057qib7 4273 17 identical identical JJ cord-005453-4057qib7 4273 18 ) ) -RRB- cord-005453-4057qib7 4273 19 . . . cord-005453-4057qib7 4274 1 Donor donor NN cord-005453-4057qib7 4274 2 - - HYPH cord-005453-4057qib7 4274 3 recipient recipient NN cord-005453-4057qib7 4274 4 ABO ABO NNP cord-005453-4057qib7 4274 5 compatibility compatibility NN cord-005453-4057qib7 4274 6 was be VBD cord-005453-4057qib7 4274 7 as as IN cord-005453-4057qib7 4274 8 follows follow VBZ cord-005453-4057qib7 4274 9 : : : cord-005453-4057qib7 4274 10 69 69 CD cord-005453-4057qib7 4274 11 ( ( -LRB- cord-005453-4057qib7 4274 12 20.1 20.1 CD cord-005453-4057qib7 4274 13 % % NN cord-005453-4057qib7 4274 14 ) ) -RRB- cord-005453-4057qib7 4274 15 majormismatched majormismatched NNP cord-005453-4057qib7 4274 16 ( ( -LRB- cord-005453-4057qib7 4274 17 including include VBG cord-005453-4057qib7 4274 18 11 11 CD cord-005453-4057qib7 4274 19 bidirectional bidirectional JJ cord-005453-4057qib7 4274 20 ) ) -RRB- cord-005453-4057qib7 4274 21 , , , cord-005453-4057qib7 4274 22 and and CC cord-005453-4057qib7 4274 23 274 274 CD cord-005453-4057qib7 4274 24 ( ( -LRB- cord-005453-4057qib7 4274 25 79.9 79.9 CD cord-005453-4057qib7 4274 26 % % NN cord-005453-4057qib7 4274 27 ) ) -RRB- cord-005453-4057qib7 4274 28 nonmajor nonmajor NN cord-005453-4057qib7 4274 29 - - HYPH cord-005453-4057qib7 4274 30 mismatched mismatched JJ cord-005453-4057qib7 4274 31 ( ( -LRB- cord-005453-4057qib7 4274 32 including include VBG cord-005453-4057qib7 4274 33 68 68 CD cord-005453-4057qib7 4274 34 minormismatched minormismatche VBN cord-005453-4057qib7 4274 35 and and CC cord-005453-4057qib7 4274 36 206 206 CD cord-005453-4057qib7 4274 37 matched match VBD cord-005453-4057qib7 4274 38 ) ) -RRB- cord-005453-4057qib7 4274 39 . . . cord-005453-4057qib7 4275 1 Donor donor NN cord-005453-4057qib7 4275 2 - - HYPH cord-005453-4057qib7 4275 3 recipient recipient NN cord-005453-4057qib7 4275 4 Rh Rh NNP cord-005453-4057qib7 4275 5 compatibility compatibility NN cord-005453-4057qib7 4275 6 was be VBD cord-005453-4057qib7 4275 7 as as IN cord-005453-4057qib7 4275 8 follows follow VBZ cord-005453-4057qib7 4275 9 : : : cord-005453-4057qib7 4275 10 50 50 CD cord-005453-4057qib7 4275 11 ( ( -LRB- cord-005453-4057qib7 4275 12 15.6 15.6 CD cord-005453-4057qib7 4275 13 % % NN cord-005453-4057qib7 4275 14 ) ) -RRB- cord-005453-4057qib7 4275 15 major major JJ cord-005453-4057qib7 4275 16 - - HYPH cord-005453-4057qib7 4275 17 mismatched mismatched JJ cord-005453-4057qib7 4275 18 , , , cord-005453-4057qib7 4275 19 and and CC cord-005453-4057qib7 4275 20 293 293 CD cord-005453-4057qib7 4275 21 ( ( -LRB- cord-005453-4057qib7 4275 22 84.4 84.4 CD cord-005453-4057qib7 4275 23 % % NN cord-005453-4057qib7 4275 24 ) ) -RRB- cord-005453-4057qib7 4275 25 nonmajor nonmajor NN cord-005453-4057qib7 4275 26 - - HYPH cord-005453-4057qib7 4275 27 mismatched mismatched JJ cord-005453-4057qib7 4275 28 ( ( -LRB- cord-005453-4057qib7 4275 29 including include VBG cord-005453-4057qib7 4275 30 34 34 CD cord-005453-4057qib7 4275 31 minor minor JJ cord-005453-4057qib7 4275 32 - - HYPH cord-005453-4057qib7 4275 33 mismatched mismatched JJ cord-005453-4057qib7 4275 34 and and CC cord-005453-4057qib7 4275 35 259 259 CD cord-005453-4057qib7 4275 36 matched match VBN cord-005453-4057qib7 4275 37 ) ) -RRB- cord-005453-4057qib7 4275 38 . . . cord-005453-4057qib7 4276 1 The the DT cord-005453-4057qib7 4276 2 impact impact NN cord-005453-4057qib7 4276 3 of of IN cord-005453-4057qib7 4276 4 donor donor NN cord-005453-4057qib7 4276 5 - - HYPH cord-005453-4057qib7 4276 6 recipient recipient NN cord-005453-4057qib7 4276 7 ABO ABO NNP cord-005453-4057qib7 4276 8 and and CC cord-005453-4057qib7 4276 9 Rh Rh NNP cord-005453-4057qib7 4276 10 compatibility compatibility NN cord-005453-4057qib7 4276 11 on on IN cord-005453-4057qib7 4276 12 transfusion transfusion NN cord-005453-4057qib7 4276 13 needs need NNS cord-005453-4057qib7 4276 14 ( ( -LRB- cord-005453-4057qib7 4276 15 PRBC PRBC NNP cord-005453-4057qib7 4276 16 and and CC cord-005453-4057qib7 4276 17 platelet platelet NN cord-005453-4057qib7 4276 18 concentrates concentrate NNS cord-005453-4057qib7 4276 19 ) ) -RRB- cord-005453-4057qib7 4276 20 and and CC cord-005453-4057qib7 4276 21 survival survival NN cord-005453-4057qib7 4276 22 by by IN cord-005453-4057qib7 4276 23 day day NN cord-005453-4057qib7 4276 24 +100 +100 NNP cord-005453-4057qib7 4276 25 was be VBD cord-005453-4057qib7 4276 26 analyzed analyze VBN cord-005453-4057qib7 4276 27 . . . cord-005453-4057qib7 4277 1 Results result NNS cord-005453-4057qib7 4277 2 : : : cord-005453-4057qib7 4278 1 For for IN cord-005453-4057qib7 4278 2 the the DT cord-005453-4057qib7 4278 3 global global JJ cord-005453-4057qib7 4278 4 series series NN cord-005453-4057qib7 4278 5 the the DT cord-005453-4057qib7 4278 6 median median JJ cord-005453-4057qib7 4278 7 number number NN cord-005453-4057qib7 4278 8 transfusions transfusion NNS cord-005453-4057qib7 4278 9 by by IN cord-005453-4057qib7 4278 10 day day NN cord-005453-4057qib7 4278 11 +100 +100 NNP cord-005453-4057qib7 4278 12 was be VBD cord-005453-4057qib7 4278 13 : : : cord-005453-4057qib7 4278 14 4 4 LS cord-005453-4057qib7 4278 15 ( ( -LRB- cord-005453-4057qib7 4278 16 0 0 CD cord-005453-4057qib7 4278 17 - - SYM cord-005453-4057qib7 4278 18 81 81 CD cord-005453-4057qib7 4278 19 ) ) -RRB- cord-005453-4057qib7 4278 20 PRBC PRBC NNP cord-005453-4057qib7 4278 21 and and CC cord-005453-4057qib7 4278 22 4 4 CD cord-005453-4057qib7 4278 23 ( ( -LRB- cord-005453-4057qib7 4278 24 0 0 CD cord-005453-4057qib7 4278 25 - - SYM cord-005453-4057qib7 4278 26 92 92 CD cord-005453-4057qib7 4278 27 ) ) -RRB- cord-005453-4057qib7 4278 28 platelets platelet NNS cord-005453-4057qib7 4278 29 concentrates concentrate VBZ cord-005453-4057qib7 4278 30 . . . cord-005453-4057qib7 4279 1 Day day NN cord-005453-4057qib7 4279 2 +100 +100 NNS cord-005453-4057qib7 4279 3 overall overall JJ cord-005453-4057qib7 4279 4 mortality mortality NN cord-005453-4057qib7 4279 5 was be VBD cord-005453-4057qib7 4279 6 9.3 9.3 CD cord-005453-4057qib7 4279 7 % % NN cord-005453-4057qib7 4279 8 . . . cord-005453-4057qib7 4280 1 Rh rh NN cord-005453-4057qib7 4280 2 - - HYPH cord-005453-4057qib7 4280 3 incompatible incompatible JJ cord-005453-4057qib7 4280 4 and and CC cord-005453-4057qib7 4280 5 nonmajor nonmajor JJ cord-005453-4057qib7 4280 6 ABO ABO NNP cord-005453-4057qib7 4280 7 incompatible incompatible JJ cord-005453-4057qib7 4280 8 cases case NNS cord-005453-4057qib7 4280 9 showed show VBD cord-005453-4057qib7 4280 10 no no DT cord-005453-4057qib7 4280 11 different different JJ cord-005453-4057qib7 4280 12 results result NNS cord-005453-4057qib7 4280 13 . . . cord-005453-4057qib7 4281 1 However however RB cord-005453-4057qib7 4281 2 , , , cord-005453-4057qib7 4281 3 major major JJ cord-005453-4057qib7 4281 4 ABOmismatched abomismatched JJ cord-005453-4057qib7 4281 5 cases case NNS cord-005453-4057qib7 4281 6 needed need VBD cord-005453-4057qib7 4281 7 more more JJR cord-005453-4057qib7 4281 8 PRBC PRBC NNP cord-005453-4057qib7 4281 9 transfusions transfusion NNS cord-005453-4057qib7 4281 10 ( ( -LRB- cord-005453-4057qib7 4281 11 median median NN cord-005453-4057qib7 4281 12 : : : cord-005453-4057qib7 4281 13 6 6 CD cord-005453-4057qib7 4281 14 ; ; : cord-005453-4057qib7 4281 15 range range NN cord-005453-4057qib7 4281 16 : : : cord-005453-4057qib7 4281 17 0 0 CD cord-005453-4057qib7 4281 18 - - SYM cord-005453-4057qib7 4281 19 49 49 CD cord-005453-4057qib7 4281 20 ) ) -RRB- cord-005453-4057qib7 4281 21 and and CC cord-005453-4057qib7 4281 22 more more JJR cord-005453-4057qib7 4281 23 platelet platelet NN cord-005453-4057qib7 4281 24 transfusions transfusion NNS cord-005453-4057qib7 4281 25 ( ( -LRB- cord-005453-4057qib7 4281 26 median median NN cord-005453-4057qib7 4281 27 : : SYM cord-005453-4057qib7 4281 28 7 7 CD cord-005453-4057qib7 4281 29 ; ; : cord-005453-4057qib7 4281 30 range range VB cord-005453-4057qib7 4281 31 : : : cord-005453-4057qib7 4281 32 0 0 CD cord-005453-4057qib7 4281 33 - - SYM cord-005453-4057qib7 4281 34 60 60 CD cord-005453-4057qib7 4281 35 ) ) -RRB- cord-005453-4057qib7 4281 36 , , , cord-005453-4057qib7 4281 37 and and CC cord-005453-4057qib7 4281 38 had have VBD cord-005453-4057qib7 4281 39 higher high JJR cord-005453-4057qib7 4281 40 day day NN cord-005453-4057qib7 4281 41 +100 +100 NNS cord-005453-4057qib7 4281 42 mortality mortality NN cord-005453-4057qib7 4281 43 ( ( -LRB- cord-005453-4057qib7 4281 44 18.8 18.8 CD cord-005453-4057qib7 4281 45 % % NN cord-005453-4057qib7 4281 46 ) ) -RRB- cord-005453-4057qib7 4281 47 ( ( -LRB- cord-005453-4057qib7 4281 48 p p NN cord-005453-4057qib7 4281 49 < < XX cord-005453-4057qib7 4281 50 0.05 0.05 CD cord-005453-4057qib7 4281 51 ) ) -RRB- cord-005453-4057qib7 4281 52 ( ( -LRB- cord-005453-4057qib7 4281 53 see see VB cord-005453-4057qib7 4281 54 table table NN cord-005453-4057qib7 4281 55 ) ) -RRB- cord-005453-4057qib7 4281 56 . . . cord-005453-4057qib7 4282 1 Conclusions conclusion NNS cord-005453-4057qib7 4282 2 : : : cord-005453-4057qib7 4283 1 Our -PRON- PRP$ cord-005453-4057qib7 4283 2 analysis analysis NN cord-005453-4057qib7 4283 3 showed show VBD cord-005453-4057qib7 4283 4 : : : cord-005453-4057qib7 4283 5 1 1 LS cord-005453-4057qib7 4283 6 ) ) -RRB- cord-005453-4057qib7 4283 7 Donor donor NN cord-005453-4057qib7 4283 8 - - HYPH cord-005453-4057qib7 4283 9 recipient recipient NN cord-005453-4057qib7 4283 10 Rh Rh NNP cord-005453-4057qib7 4283 11 - - HYPH cord-005453-4057qib7 4283 12 incompatibility incompatibility NN cord-005453-4057qib7 4283 13 , , , cord-005453-4057qib7 4283 14 as as RB cord-005453-4057qib7 4283 15 well well RB cord-005453-4057qib7 4283 16 as as IN cord-005453-4057qib7 4283 17 minor minor JJ cord-005453-4057qib7 4283 18 ABOincompatibility aboincompatibility NN cord-005453-4057qib7 4283 19 had have VBD cord-005453-4057qib7 4283 20 no no DT cord-005453-4057qib7 4283 21 impact impact NN cord-005453-4057qib7 4283 22 on on IN cord-005453-4057qib7 4283 23 PRBC PRBC NNP cord-005453-4057qib7 4283 24 and and CC cord-005453-4057qib7 4283 25 platelet platelet NN cord-005453-4057qib7 4283 26 concentrates concentrate VBZ cord-005453-4057qib7 4283 27 transfusion transfusion NN cord-005453-4057qib7 4283 28 needs need NNS cord-005453-4057qib7 4283 29 nor nor CC cord-005453-4057qib7 4283 30 on on IN cord-005453-4057qib7 4283 31 100-day 100-day CD cord-005453-4057qib7 4283 32 mortality mortality NN cord-005453-4057qib7 4283 33 ; ; : cord-005453-4057qib7 4283 34 2 2 LS cord-005453-4057qib7 4283 35 ) ) -RRB- cord-005453-4057qib7 4284 1 Contrarily contrarily RB cord-005453-4057qib7 4284 2 , , , cord-005453-4057qib7 4284 3 donor donor NN cord-005453-4057qib7 4284 4 - - HYPH cord-005453-4057qib7 4284 5 recipient recipient NN cord-005453-4057qib7 4284 6 major major JJ cord-005453-4057qib7 4284 7 ABO ABO NNP cord-005453-4057qib7 4284 8 - - HYPH cord-005453-4057qib7 4284 9 incompatibility incompatibility NN cord-005453-4057qib7 4284 10 had have VBD cord-005453-4057qib7 4284 11 a a DT cord-005453-4057qib7 4284 12 significant significant JJ cord-005453-4057qib7 4284 13 adverse adverse JJ cord-005453-4057qib7 4284 14 impact impact NN cord-005453-4057qib7 4284 15 on on IN cord-005453-4057qib7 4284 16 PRBC PRBC NNP cord-005453-4057qib7 4284 17 and and CC cord-005453-4057qib7 4284 18 platelet platelet NN cord-005453-4057qib7 4284 19 concentrates concentrate VBZ cord-005453-4057qib7 4284 20 transfusion transfusion NN cord-005453-4057qib7 4284 21 needs need NNS cord-005453-4057qib7 4284 22 and and CC cord-005453-4057qib7 4284 23 100-day 100-day JJ cord-005453-4057qib7 4284 24 mortality mortality NN cord-005453-4057qib7 4284 25 . . . cord-005453-4057qib7 4285 1 3 3 LS cord-005453-4057qib7 4285 2 ) ) -RRB- cord-005453-4057qib7 4285 3 Donor donor NN cord-005453-4057qib7 4285 4 - - HYPH cord-005453-4057qib7 4285 5 recipient recipient NN cord-005453-4057qib7 4285 6 Rh Rh NNP cord-005453-4057qib7 4285 7 - - HYPH cord-005453-4057qib7 4285 8 incompatibility incompatibility NN cord-005453-4057qib7 4285 9 and and CC cord-005453-4057qib7 4285 10 minor minor JJ cord-005453-4057qib7 4285 11 ABOincompatibility.might aboincompatibility.might NN cord-005453-4057qib7 4285 12 be be VB cord-005453-4057qib7 4285 13 considered consider VBN cord-005453-4057qib7 4285 14 of of IN cord-005453-4057qib7 4285 15 marginal marginal JJ cord-005453-4057qib7 4285 16 importance importance NN cord-005453-4057qib7 4285 17 at at IN cord-005453-4057qib7 4285 18 the the DT cord-005453-4057qib7 4285 19 time time NN cord-005453-4057qib7 4285 20 to to TO cord-005453-4057qib7 4285 21 choose choose VB cord-005453-4057qib7 4285 22 a a DT cord-005453-4057qib7 4285 23 potential potential JJ cord-005453-4057qib7 4285 24 donor donor NN cord-005453-4057qib7 4285 25 . . . cord-005453-4057qib7 4286 1 4 4 LS cord-005453-4057qib7 4286 2 ) ) -RRB- cord-005453-4057qib7 4287 1 Donorrecipient donorrecipient JJ cord-005453-4057qib7 4287 2 major major JJ cord-005453-4057qib7 4287 3 ABO ABO NNP cord-005453-4057qib7 4287 4 - - HYPH cord-005453-4057qib7 4287 5 incompatibility incompatibility NN cord-005453-4057qib7 4287 6 should should MD cord-005453-4057qib7 4287 7 probably probably RB cord-005453-4057qib7 4287 8 be be VB cord-005453-4057qib7 4287 9 a a DT cord-005453-4057qib7 4287 10 factor factor NN cord-005453-4057qib7 4287 11 to to TO cord-005453-4057qib7 4287 12 be be VB cord-005453-4057qib7 4287 13 considered consider VBN cord-005453-4057qib7 4287 14 , , , cord-005453-4057qib7 4287 15 along along IN cord-005453-4057qib7 4287 16 with with IN cord-005453-4057qib7 4287 17 other other JJ cord-005453-4057qib7 4287 18 features feature NNS cord-005453-4057qib7 4287 19 , , , cord-005453-4057qib7 4287 20 to to TO cord-005453-4057qib7 4287 21 choose choose VB cord-005453-4057qib7 4287 22 the the DT cord-005453-4057qib7 4287 23 best good JJS cord-005453-4057qib7 4287 24 donor donor NN cord-005453-4057qib7 4287 25 Background background NN cord-005453-4057qib7 4287 26 : : : cord-005453-4057qib7 4288 1 Survivors survivor NNS cord-005453-4057qib7 4288 2 of of IN cord-005453-4057qib7 4288 3 haematopoietic haematopoietic JJ cord-005453-4057qib7 4288 4 stem stem NN cord-005453-4057qib7 4288 5 cell cell NN cord-005453-4057qib7 4288 6 transplantation transplantation NN cord-005453-4057qib7 4288 7 ( ( -LRB- cord-005453-4057qib7 4288 8 HSCT HSCT NNP cord-005453-4057qib7 4288 9 ) ) -RRB- cord-005453-4057qib7 4288 10 are be VBP cord-005453-4057qib7 4288 11 at at IN cord-005453-4057qib7 4288 12 significant significant JJ cord-005453-4057qib7 4288 13 risk risk NN cord-005453-4057qib7 4288 14 of of IN cord-005453-4057qib7 4288 15 developing develop VBG cord-005453-4057qib7 4288 16 treatment treatment NN cord-005453-4057qib7 4288 17 - - HYPH cord-005453-4057qib7 4288 18 related relate VBN cord-005453-4057qib7 4288 19 complications complication NNS cord-005453-4057qib7 4288 20 , , , cord-005453-4057qib7 4288 21 including include VBG cord-005453-4057qib7 4288 22 cardiovascular cardiovascular JJ cord-005453-4057qib7 4288 23 risk risk NN cord-005453-4057qib7 4288 24 factors factor NNS cord-005453-4057qib7 4288 25 such such JJ cord-005453-4057qib7 4288 26 as as IN cord-005453-4057qib7 4288 27 arterial arterial JJ cord-005453-4057qib7 4288 28 hypertension hypertension NN cord-005453-4057qib7 4288 29 , , , cord-005453-4057qib7 4288 30 that that WDT cord-005453-4057qib7 4288 31 could could MD cord-005453-4057qib7 4288 32 eventually eventually RB cord-005453-4057qib7 4288 33 lead lead VB cord-005453-4057qib7 4288 34 to to IN cord-005453-4057qib7 4288 35 cardiovascular cardiovascular JJ cord-005453-4057qib7 4288 36 disease disease NN cord-005453-4057qib7 4288 37 . . . cord-005453-4057qib7 4289 1 The the DT cord-005453-4057qib7 4289 2 aim aim NN cord-005453-4057qib7 4289 3 of of IN cord-005453-4057qib7 4289 4 this this DT cord-005453-4057qib7 4289 5 study study NN cord-005453-4057qib7 4289 6 is be VBZ cord-005453-4057qib7 4289 7 to to TO cord-005453-4057qib7 4289 8 evaluate evaluate VB cord-005453-4057qib7 4289 9 the the DT cord-005453-4057qib7 4289 10 incidence incidence NN cord-005453-4057qib7 4289 11 and and CC cord-005453-4057qib7 4289 12 risk risk NN cord-005453-4057qib7 4289 13 factors factor NNS cord-005453-4057qib7 4289 14 of of IN cord-005453-4057qib7 4289 15 hypertension hypertension NN cord-005453-4057qib7 4289 16 following follow VBG cord-005453-4057qib7 4289 17 HSCT HSCT NNP cord-005453-4057qib7 4289 18 in in IN cord-005453-4057qib7 4289 19 a a DT cord-005453-4057qib7 4289 20 Colombian colombian JJ cord-005453-4057qib7 4289 21 population population NN cord-005453-4057qib7 4289 22 . . . cord-005453-4057qib7 4290 1 Methods method NNS cord-005453-4057qib7 4290 2 : : : cord-005453-4057qib7 4291 1 A a DT cord-005453-4057qib7 4291 2 retrospective retrospective JJ cord-005453-4057qib7 4291 3 cohort cohort NN cord-005453-4057qib7 4291 4 study study NN cord-005453-4057qib7 4291 5 was be VBD cord-005453-4057qib7 4291 6 conducted conduct VBN cord-005453-4057qib7 4291 7 to to TO cord-005453-4057qib7 4291 8 assess assess VB cord-005453-4057qib7 4291 9 the the DT cord-005453-4057qib7 4291 10 incidence incidence NN cord-005453-4057qib7 4291 11 and and CC cord-005453-4057qib7 4291 12 risk risk NN cord-005453-4057qib7 4291 13 factors factor NNS cord-005453-4057qib7 4291 14 of of IN cord-005453-4057qib7 4291 15 hypertension hypertension NN cord-005453-4057qib7 4291 16 in in IN cord-005453-4057qib7 4291 17 220 220 CD cord-005453-4057qib7 4291 18 consecutive consecutive JJ cord-005453-4057qib7 4291 19 adult adult NN cord-005453-4057qib7 4291 20 HSCT HSCT NNP cord-005453-4057qib7 4291 21 recipients recipient NNS cord-005453-4057qib7 4291 22 who who WP cord-005453-4057qib7 4291 23 underwent undergo VBD cord-005453-4057qib7 4291 24 transplantation transplantation NN cord-005453-4057qib7 4291 25 between between IN cord-005453-4057qib7 4291 26 2009 2009 CD cord-005453-4057qib7 4291 27 and and CC cord-005453-4057qib7 4291 28 2017 2017 CD cord-005453-4057qib7 4291 29 at at IN cord-005453-4057qib7 4291 30 a a DT cord-005453-4057qib7 4291 31 tertiary tertiary JJ cord-005453-4057qib7 4291 32 referral referral JJ cord-005453-4057qib7 4291 33 center center NN cord-005453-4057qib7 4291 34 in in IN cord-005453-4057qib7 4291 35 Colombia Colombia NNP cord-005453-4057qib7 4291 36 , , , cord-005453-4057qib7 4291 37 South South NNP cord-005453-4057qib7 4291 38 America America NNP cord-005453-4057qib7 4291 39 . . . cord-005453-4057qib7 4292 1 Blood blood NN cord-005453-4057qib7 4292 2 pressure pressure NN cord-005453-4057qib7 4292 3 data datum NNS cord-005453-4057qib7 4292 4 , , , cord-005453-4057qib7 4292 5 from from IN cord-005453-4057qib7 4292 6 two two CD cord-005453-4057qib7 4292 7 different different JJ cord-005453-4057qib7 4292 8 measures measure NNS cord-005453-4057qib7 4292 9 , , , cord-005453-4057qib7 4292 10 were be VBD cord-005453-4057qib7 4292 11 collected collect VBN cord-005453-4057qib7 4292 12 at at IN cord-005453-4057qib7 4292 13 7 7 CD cord-005453-4057qib7 4292 14 time time NN cord-005453-4057qib7 4292 15 points point NNS cord-005453-4057qib7 4292 16 : : : cord-005453-4057qib7 4292 17 day day NN cord-005453-4057qib7 4292 18 of of IN cord-005453-4057qib7 4292 19 mobilization mobilization NN cord-005453-4057qib7 4292 20 for for IN cord-005453-4057qib7 4292 21 autologous autologous JJ cord-005453-4057qib7 4292 22 HSCT HSCT NNP cord-005453-4057qib7 4292 23 and and CC cord-005453-4057qib7 4292 24 day day NN cord-005453-4057qib7 4292 25 0 0 CD cord-005453-4057qib7 4292 26 before before IN cord-005453-4057qib7 4292 27 infusion infusion NN cord-005453-4057qib7 4292 28 for for IN cord-005453-4057qib7 4292 29 allogeneic allogeneic NN cord-005453-4057qib7 4292 30 transplantation transplantation NN cord-005453-4057qib7 4292 31 , , , cord-005453-4057qib7 4292 32 day day NN cord-005453-4057qib7 4292 33 7 7 CD cord-005453-4057qib7 4292 34 , , , cord-005453-4057qib7 4292 35 and and CC cord-005453-4057qib7 4292 36 months month NNS cord-005453-4057qib7 4292 37 1 1 CD cord-005453-4057qib7 4292 38 , , , cord-005453-4057qib7 4292 39 3 3 CD cord-005453-4057qib7 4292 40 , , , cord-005453-4057qib7 4292 41 6 6 CD cord-005453-4057qib7 4292 42 and and CC cord-005453-4057qib7 4292 43 12 12 CD cord-005453-4057qib7 4292 44 post post NN cord-005453-4057qib7 4292 45 - - NN cord-005453-4057qib7 4292 46 transplantation transplantation NN cord-005453-4057qib7 4292 47 . . . cord-005453-4057qib7 4293 1 Hypertension hypertension NN cord-005453-4057qib7 4293 2 was be VBD cord-005453-4057qib7 4293 3 defined define VBN cord-005453-4057qib7 4293 4 as as IN cord-005453-4057qib7 4293 5 having have VBG cord-005453-4057qib7 4293 6 a a DT cord-005453-4057qib7 4293 7 systolic systolic JJ cord-005453-4057qib7 4293 8 blood blood NN cord-005453-4057qib7 4293 9 pressure pressure NN cord-005453-4057qib7 4293 10 > > XX cord-005453-4057qib7 4294 1 = = SYM cord-005453-4057qib7 4294 2 140mmHg 140mmHg NNS cord-005453-4057qib7 4294 3 and/or and/or CC cord-005453-4057qib7 4295 1 a a DT cord-005453-4057qib7 4295 2 diastolic diastolic JJ cord-005453-4057qib7 4295 3 blood blood NN cord-005453-4057qib7 4295 4 pressure pressure NN cord-005453-4057qib7 4295 5 > > XX cord-005453-4057qib7 4296 1 = = SYM cord-005453-4057qib7 4296 2 90 90 CD cord-005453-4057qib7 4296 3 mmHg mmHg NNS cord-005453-4057qib7 4296 4 . . . cord-005453-4057qib7 4296 5 Patients patient NNS cord-005453-4057qib7 4296 6 with with IN cord-005453-4057qib7 4296 7 history history NN cord-005453-4057qib7 4296 8 of of IN cord-005453-4057qib7 4296 9 arterial arterial JJ cord-005453-4057qib7 4296 10 hypertension hypertension NN cord-005453-4057qib7 4296 11 were be VBD cord-005453-4057qib7 4296 12 excluded exclude VBN cord-005453-4057qib7 4296 13 . . . cord-005453-4057qib7 4297 1 Results result NNS cord-005453-4057qib7 4297 2 : : : cord-005453-4057qib7 4298 1 One one CD cord-005453-4057qib7 4298 2 hundred hundred CD cord-005453-4057qib7 4298 3 and and CC cord-005453-4057qib7 4298 4 seventy seventy CD cord-005453-4057qib7 4298 5 - - HYPH cord-005453-4057qib7 4298 6 five five CD cord-005453-4057qib7 4298 7 patients patient NNS cord-005453-4057qib7 4298 8 were be VBD cord-005453-4057qib7 4298 9 included include VBN cord-005453-4057qib7 4298 10 , , , cord-005453-4057qib7 4298 11 with with IN cord-005453-4057qib7 4298 12 a a DT cord-005453-4057qib7 4298 13 mean mean JJ cord-005453-4057qib7 4298 14 age age NN cord-005453-4057qib7 4298 15 of of IN cord-005453-4057qib7 4298 16 44 44 CD cord-005453-4057qib7 4298 17 years year NNS cord-005453-4057qib7 4298 18 ( ( -LRB- cord-005453-4057qib7 4298 19 range range VBP cord-005453-4057qib7 4298 20 15 15 CD cord-005453-4057qib7 4298 21 - - SYM cord-005453-4057qib7 4298 22 67 67 CD cord-005453-4057qib7 4298 23 ) ) -RRB- cord-005453-4057qib7 4298 24 . . . cord-005453-4057qib7 4299 1 Ninety ninety CD cord-005453-4057qib7 4299 2 - - HYPH cord-005453-4057qib7 4299 3 one one CD cord-005453-4057qib7 4299 4 patients patient NNS cord-005453-4057qib7 4299 5 ( ( -LRB- cord-005453-4057qib7 4299 6 52 52 CD cord-005453-4057qib7 4299 7 % % NN cord-005453-4057qib7 4299 8 ) ) -RRB- cord-005453-4057qib7 4299 9 were be VBD cord-005453-4057qib7 4299 10 male male JJ cord-005453-4057qib7 4299 11 . . . cord-005453-4057qib7 4300 1 One one CD cord-005453-4057qib7 4300 2 hundred hundred CD cord-005453-4057qib7 4300 3 and and CC cord-005453-4057qib7 4300 4 sixteen sixteen CD cord-005453-4057qib7 4300 5 patients patient NNS cord-005453-4057qib7 4300 6 ( ( -LRB- cord-005453-4057qib7 4300 7 66.3 66.3 CD cord-005453-4057qib7 4300 8 % % NN cord-005453-4057qib7 4300 9 ) ) -RRB- cord-005453-4057qib7 4300 10 underwent undergo VBD cord-005453-4057qib7 4300 11 autologous autologous JJ cord-005453-4057qib7 4300 12 HSCT HSCT NNP cord-005453-4057qib7 4300 13 and and CC cord-005453-4057qib7 4300 14 59 59 CD cord-005453-4057qib7 4300 15 ( ( -LRB- cord-005453-4057qib7 4300 16 33.7 33.7 CD cord-005453-4057qib7 4300 17 % % NN cord-005453-4057qib7 4300 18 ) ) -RRB- cord-005453-4057qib7 4300 19 allogeneic allogeneic IN cord-005453-4057qib7 4300 20 HSCT HSCT NNP cord-005453-4057qib7 4300 21 . . . cord-005453-4057qib7 4301 1 The the DT cord-005453-4057qib7 4301 2 most most RBS cord-005453-4057qib7 4301 3 common common JJ cord-005453-4057qib7 4301 4 indication indication NN cord-005453-4057qib7 4301 5 for for IN cord-005453-4057qib7 4301 6 HSCT HSCT NNP cord-005453-4057qib7 4301 7 was be VBD cord-005453-4057qib7 4301 8 acute acute JJ cord-005453-4057qib7 4301 9 leukemia leukemia NN cord-005453-4057qib7 4301 10 ( ( -LRB- cord-005453-4057qib7 4301 11 26.3 26.3 CD cord-005453-4057qib7 4301 12 % % NN cord-005453-4057qib7 4301 13 ) ) -RRB- cord-005453-4057qib7 4301 14 , , , cord-005453-4057qib7 4301 15 followed follow VBN cord-005453-4057qib7 4301 16 by by IN cord-005453-4057qib7 4301 17 non non JJ cord-005453-4057qib7 4301 18 - - JJ cord-005453-4057qib7 4301 19 Hodgkin Hodgkin NNP cord-005453-4057qib7 4301 20 lymphoma lymphoma NN cord-005453-4057qib7 4301 21 ( ( -LRB- cord-005453-4057qib7 4301 22 23.4 23.4 CD cord-005453-4057qib7 4301 23 % % NN cord-005453-4057qib7 4301 24 ) ) -RRB- cord-005453-4057qib7 4301 25 and and CC cord-005453-4057qib7 4301 26 multiple multiple JJ cord-005453-4057qib7 4301 27 myeloma myeloma NN cord-005453-4057qib7 4301 28 ( ( -LRB- cord-005453-4057qib7 4301 29 22.9 22.9 CD cord-005453-4057qib7 4301 30 % % NN cord-005453-4057qib7 4301 31 ) ) -RRB- cord-005453-4057qib7 4301 32 . . . cord-005453-4057qib7 4302 1 Twelve twelve CD cord-005453-4057qib7 4302 2 patients patient NNS cord-005453-4057qib7 4302 3 ( ( -LRB- cord-005453-4057qib7 4302 4 6.9 6.9 CD cord-005453-4057qib7 4302 5 % % NN cord-005453-4057qib7 4302 6 ) ) -RRB- cord-005453-4057qib7 4302 7 had have VBD cord-005453-4057qib7 4302 8 medical medical JJ cord-005453-4057qib7 4302 9 history history NN cord-005453-4057qib7 4302 10 of of IN cord-005453-4057qib7 4302 11 type type NN cord-005453-4057qib7 4302 12 2 2 CD cord-005453-4057qib7 4302 13 diabetes diabetes NN cord-005453-4057qib7 4302 14 mellitus mellitus NN cord-005453-4057qib7 4302 15 ( ( -LRB- cord-005453-4057qib7 4302 16 DM DM NNP cord-005453-4057qib7 4302 17 ) ) -RRB- cord-005453-4057qib7 4302 18 , , , cord-005453-4057qib7 4302 19 11 11 CD cord-005453-4057qib7 4302 20 ( ( -LRB- cord-005453-4057qib7 4302 21 6.3 6.3 CD cord-005453-4057qib7 4302 22 % % NN cord-005453-4057qib7 4302 23 ) ) -RRB- cord-005453-4057qib7 4302 24 dyslipidemia dyslipidemia NN cord-005453-4057qib7 4302 25 , , , cord-005453-4057qib7 4302 26 24 24 CD cord-005453-4057qib7 4302 27 ( ( -LRB- cord-005453-4057qib7 4302 28 13.7 13.7 CD cord-005453-4057qib7 4302 29 % % NN cord-005453-4057qib7 4302 30 ) ) -RRB- cord-005453-4057qib7 4302 31 alcohol alcohol NN cord-005453-4057qib7 4302 32 consumption consumption NN cord-005453-4057qib7 4302 33 , , , cord-005453-4057qib7 4302 34 and and CC cord-005453-4057qib7 4302 35 25 25 CD cord-005453-4057qib7 4302 36 ( ( -LRB- cord-005453-4057qib7 4302 37 14.3 14.3 CD cord-005453-4057qib7 4302 38 % % NN cord-005453-4057qib7 4302 39 ) ) -RRB- cord-005453-4057qib7 4302 40 tobacco tobacco NN cord-005453-4057qib7 4302 41 smoking smoking NN cord-005453-4057qib7 4302 42 . . . cord-005453-4057qib7 4303 1 Only only RB cord-005453-4057qib7 4303 2 two two CD cord-005453-4057qib7 4303 3 of of IN cord-005453-4057qib7 4303 4 the the DT cord-005453-4057qib7 4303 5 patients patient NNS cord-005453-4057qib7 4303 6 with with IN cord-005453-4057qib7 4303 7 history history NN cord-005453-4057qib7 4303 8 of of IN cord-005453-4057qib7 4303 9 tobacco tobacco NN cord-005453-4057qib7 4303 10 smoking smoking NN cord-005453-4057qib7 4303 11 were be VBD cord-005453-4057qib7 4303 12 active active JJ cord-005453-4057qib7 4303 13 smokers smoker NNS cord-005453-4057qib7 4303 14 at at IN cord-005453-4057qib7 4303 15 time time NN cord-005453-4057qib7 4303 16 of of IN cord-005453-4057qib7 4303 17 transplantation transplantation NN cord-005453-4057qib7 4303 18 . . . cord-005453-4057qib7 4304 1 Twenty twenty CD cord-005453-4057qib7 4304 2 - - HYPH cord-005453-4057qib7 4304 3 four four CD cord-005453-4057qib7 4304 4 patients patient NNS cord-005453-4057qib7 4304 5 ( ( -LRB- cord-005453-4057qib7 4304 6 13.7 13.7 CD cord-005453-4057qib7 4304 7 % % NN cord-005453-4057qib7 4304 8 ) ) -RRB- cord-005453-4057qib7 4304 9 had have VBD cord-005453-4057qib7 4304 10 developed develop VBN cord-005453-4057qib7 4304 11 hypertension hypertension NN cord-005453-4057qib7 4304 12 by by IN cord-005453-4057qib7 4304 13 the the DT cord-005453-4057qib7 4304 14 end end NN cord-005453-4057qib7 4304 15 of of IN cord-005453-4057qib7 4304 16 the the DT cord-005453-4057qib7 4304 17 first first JJ cord-005453-4057qib7 4304 18 year year NN cord-005453-4057qib7 4304 19 post post NN cord-005453-4057qib7 4304 20 - - JJ cord-005453-4057qib7 4304 21 HSCT hsct JJ cord-005453-4057qib7 4304 22 follow follow NN cord-005453-4057qib7 4304 23 - - HYPH cord-005453-4057qib7 4304 24 up up NN cord-005453-4057qib7 4304 25 . . . cord-005453-4057qib7 4305 1 Two two CD cord-005453-4057qib7 4305 2 patients patient NNS cord-005453-4057qib7 4305 3 ( ( -LRB- cord-005453-4057qib7 4305 4 8.3 8.3 CD cord-005453-4057qib7 4305 5 % % NN cord-005453-4057qib7 4305 6 ) ) -RRB- cord-005453-4057qib7 4305 7 had have VBD cord-005453-4057qib7 4305 8 systolic systolic JJ cord-005453-4057qib7 4305 9 and and CC cord-005453-4057qib7 4305 10 diastolic diastolic JJ cord-005453-4057qib7 4305 11 , , , cord-005453-4057qib7 4305 12 12 12 CD cord-005453-4057qib7 4305 13 ( ( -LRB- cord-005453-4057qib7 4305 14 50 50 CD cord-005453-4057qib7 4305 15 % % NN cord-005453-4057qib7 4305 16 ) ) -RRB- cord-005453-4057qib7 4305 17 had have VBD cord-005453-4057qib7 4305 18 only only RB cord-005453-4057qib7 4305 19 systolic systolic JJ cord-005453-4057qib7 4305 20 , , , cord-005453-4057qib7 4305 21 and and CC cord-005453-4057qib7 4305 22 10 10 CD cord-005453-4057qib7 4305 23 ( ( -LRB- cord-005453-4057qib7 4305 24 41.7 41.7 CD cord-005453-4057qib7 4305 25 % % NN cord-005453-4057qib7 4305 26 ) ) -RRB- cord-005453-4057qib7 4305 27 had have VBD cord-005453-4057qib7 4305 28 only only RB cord-005453-4057qib7 4305 29 diastolic diastolic JJ cord-005453-4057qib7 4305 30 hypertension hypertension NN cord-005453-4057qib7 4305 31 . . . cord-005453-4057qib7 4306 1 Only only RB cord-005453-4057qib7 4306 2 one one CD cord-005453-4057qib7 4306 3 patient patient NN cord-005453-4057qib7 4306 4 was be VBD cord-005453-4057qib7 4306 5 hypertensive hypertensive JJ cord-005453-4057qib7 4306 6 at at IN cord-005453-4057qib7 4306 7 more more JJR cord-005453-4057qib7 4306 8 than than IN cord-005453-4057qib7 4306 9 two two CD cord-005453-4057qib7 4306 10 time time NN cord-005453-4057qib7 4306 11 points point NNS cord-005453-4057qib7 4306 12 . . . cord-005453-4057qib7 4307 1 The the DT cord-005453-4057qib7 4307 2 incidences incidence NNS cord-005453-4057qib7 4307 3 of of IN cord-005453-4057qib7 4307 4 hypertension hypertension NN cord-005453-4057qib7 4307 5 at at IN cord-005453-4057qib7 4307 6 each each DT cord-005453-4057qib7 4307 7 time time NN cord-005453-4057qib7 4307 8 point point NN cord-005453-4057qib7 4307 9 were be VBD cord-005453-4057qib7 4307 10 2.3 2.3 CD cord-005453-4057qib7 4307 11 % % NN cord-005453-4057qib7 4307 12 on on IN cord-005453-4057qib7 4307 13 day day NN cord-005453-4057qib7 4307 14 7 7 CD cord-005453-4057qib7 4307 15 post post JJ cord-005453-4057qib7 4307 16 - - JJ cord-005453-4057qib7 4307 17 HSCT HSCT NNP cord-005453-4057qib7 4307 18 , , , cord-005453-4057qib7 4307 19 6.9 6.9 CD cord-005453-4057qib7 4307 20 % % NN cord-005453-4057qib7 4307 21 at at IN cord-005453-4057qib7 4307 22 first first JJ cord-005453-4057qib7 4307 23 month month NN cord-005453-4057qib7 4307 24 , , , cord-005453-4057qib7 4307 25 9.8 9.8 CD cord-005453-4057qib7 4307 26 % % NN cord-005453-4057qib7 4307 27 at at IN cord-005453-4057qib7 4307 28 three three CD cord-005453-4057qib7 4307 29 months month NNS cord-005453-4057qib7 4307 30 , , , cord-005453-4057qib7 4307 31 12.1 12.1 CD cord-005453-4057qib7 4307 32 % % NN cord-005453-4057qib7 4307 33 at at IN cord-005453-4057qib7 4307 34 6 6 CD cord-005453-4057qib7 4307 35 months month NNS cord-005453-4057qib7 4307 36 , , , cord-005453-4057qib7 4307 37 and and CC cord-005453-4057qib7 4307 38 13.8 13.8 CD cord-005453-4057qib7 4307 39 % % NN cord-005453-4057qib7 4307 40 at at IN cord-005453-4057qib7 4307 41 one one CD cord-005453-4057qib7 4307 42 - - HYPH cord-005453-4057qib7 4307 43 year year NN cord-005453-4057qib7 4307 44 post post NN cord-005453-4057qib7 4307 45 - - NN cord-005453-4057qib7 4307 46 transplantation transplantation NN cord-005453-4057qib7 4307 47 . . . cord-005453-4057qib7 4308 1 Allogeneic allogeneic IN cord-005453-4057qib7 4308 2 HSCT HSCT NNP cord-005453-4057qib7 4308 3 ( ( -LRB- cord-005453-4057qib7 4308 4 P p NN cord-005453-4057qib7 4308 5 < < XX cord-005453-4057qib7 4308 6 0.01 0.01 CD cord-005453-4057qib7 4308 7 ) ) -RRB- cord-005453-4057qib7 4308 8 , , , cord-005453-4057qib7 4308 9 therapy therapy NN cord-005453-4057qib7 4308 10 with with IN cord-005453-4057qib7 4308 11 calcineurin calcineurin NNP cord-005453-4057qib7 4308 12 inhibitors inhibitor NNS cord-005453-4057qib7 4308 13 ( ( -LRB- cord-005453-4057qib7 4308 14 P p NN cord-005453-4057qib7 4308 15 < < XX cord-005453-4057qib7 4308 16 0.01 0.01 CD cord-005453-4057qib7 4308 17 ) ) -RRB- cord-005453-4057qib7 4308 18 , , , cord-005453-4057qib7 4308 19 pre pre VBN cord-005453-4057qib7 4308 20 - - JJ cord-005453-4057qib7 4308 21 HSCT hsct JJ cord-005453-4057qib7 4308 22 fasting fast VBG cord-005453-4057qib7 4308 23 glucose glucose NN cord-005453-4057qib7 4308 24 levels level NNS cord-005453-4057qib7 4308 25 ( ( -LRB- cord-005453-4057qib7 4308 26 P p NN cord-005453-4057qib7 4308 27 < < XX cord-005453-4057qib7 4308 28 0.05 0.05 CD cord-005453-4057qib7 4308 29 ) ) -RRB- cord-005453-4057qib7 4308 30 , , , cord-005453-4057qib7 4308 31 acute acute JJ cord-005453-4057qib7 4308 32 GvHD GvHD NNP cord-005453-4057qib7 4308 33 ( ( -LRB- cord-005453-4057qib7 4308 34 P p NN cord-005453-4057qib7 4308 35 < < XX cord-005453-4057qib7 4308 36 0.05 0.05 CD cord-005453-4057qib7 4308 37 ) ) -RRB- cord-005453-4057qib7 4308 38 , , , cord-005453-4057qib7 4308 39 chronic chronic JJ cord-005453-4057qib7 4308 40 GvHD GvHD NNP cord-005453-4057qib7 4308 41 ( ( -LRB- cord-005453-4057qib7 4308 42 P p NN cord-005453-4057qib7 4308 43 < < XX cord-005453-4057qib7 4308 44 0.05 0.05 CD cord-005453-4057qib7 4308 45 ) ) -RRB- cord-005453-4057qib7 4308 46 , , , cord-005453-4057qib7 4308 47 and and CC cord-005453-4057qib7 4308 48 media medium NNS cord-005453-4057qib7 4308 49 of of IN cord-005453-4057qib7 4308 50 diastolic diastolic JJ cord-005453-4057qib7 4308 51 blood blood NN cord-005453-4057qib7 4308 52 pressure pressure NN cord-005453-4057qib7 4308 53 ( ( -LRB- cord-005453-4057qib7 4308 54 P p NN cord-005453-4057qib7 4308 55 < < XX cord-005453-4057qib7 4308 56 0.05 0.05 CD cord-005453-4057qib7 4308 57 ) ) -RRB- cord-005453-4057qib7 4308 58 were be VBD cord-005453-4057qib7 4308 59 significantly significantly RB cord-005453-4057qib7 4308 60 associated associate VBN cord-005453-4057qib7 4308 61 with with IN cord-005453-4057qib7 4308 62 the the DT cord-005453-4057qib7 4308 63 development development NN cord-005453-4057qib7 4308 64 of of IN cord-005453-4057qib7 4308 65 arterial arterial JJ cord-005453-4057qib7 4308 66 hypertension hypertension NN cord-005453-4057qib7 4308 67 . . . cord-005453-4057qib7 4309 1 However however RB cord-005453-4057qib7 4309 2 , , , cord-005453-4057qib7 4309 3 age age NN cord-005453-4057qib7 4309 4 , , , cord-005453-4057qib7 4309 5 history history NN cord-005453-4057qib7 4309 6 of of IN cord-005453-4057qib7 4309 7 type type NN cord-005453-4057qib7 4309 8 2 2 CD cord-005453-4057qib7 4309 9 DM dm NN cord-005453-4057qib7 4309 10 , , , cord-005453-4057qib7 4309 11 history history NN cord-005453-4057qib7 4309 12 of of IN cord-005453-4057qib7 4309 13 tobacco tobacco NN cord-005453-4057qib7 4309 14 consumption consumption NN cord-005453-4057qib7 4309 15 , , , cord-005453-4057qib7 4309 16 volume volume NN cord-005453-4057qib7 4309 17 of of IN cord-005453-4057qib7 4309 18 infusion infusion NN cord-005453-4057qib7 4309 19 , , , cord-005453-4057qib7 4309 20 prophylactic prophylactic JJ cord-005453-4057qib7 4309 21 treatment treatment NN cord-005453-4057qib7 4309 22 for for IN cord-005453-4057qib7 4309 23 GvHD GvHD NNP cord-005453-4057qib7 4309 24 with with IN cord-005453-4057qib7 4309 25 mycophenolate mycophenolate NNP cord-005453-4057qib7 4309 26 , , , cord-005453-4057qib7 4309 27 chronic chronic JJ cord-005453-4057qib7 4309 28 GvHD gvhd NN cord-005453-4057qib7 4309 29 , , , cord-005453-4057qib7 4309 30 serum serum NN cord-005453-4057qib7 4309 31 creatinine creatinine NN cord-005453-4057qib7 4309 32 level level NN cord-005453-4057qib7 4309 33 on on IN cord-005453-4057qib7 4309 34 day day NN cord-005453-4057qib7 4309 35 of of IN cord-005453-4057qib7 4309 36 HSCT HSCT NNP cord-005453-4057qib7 4309 37 , , , cord-005453-4057qib7 4309 38 and and CC cord-005453-4057qib7 4309 39 being be VBG cord-005453-4057qib7 4309 40 overweight overweight JJ cord-005453-4057qib7 4309 41 or or CC cord-005453-4057qib7 4309 42 obese obese JJ cord-005453-4057qib7 4309 43 at at IN cord-005453-4057qib7 4309 44 time time NN cord-005453-4057qib7 4309 45 of of IN cord-005453-4057qib7 4309 46 transplantation transplantation NN cord-005453-4057qib7 4309 47 were be VBD cord-005453-4057qib7 4309 48 not not RB cord-005453-4057qib7 4309 49 significantly significantly RB cord-005453-4057qib7 4309 50 associated associate VBN cord-005453-4057qib7 4309 51 with with IN cord-005453-4057qib7 4309 52 the the DT cord-005453-4057qib7 4309 53 development development NN cord-005453-4057qib7 4309 54 of of IN cord-005453-4057qib7 4309 55 hypertension hypertension NN cord-005453-4057qib7 4309 56 . . . cord-005453-4057qib7 4310 1 Conclusions conclusion NNS cord-005453-4057qib7 4310 2 : : : cord-005453-4057qib7 4311 1 Arterial arterial JJ cord-005453-4057qib7 4311 2 hypertension hypertension NN cord-005453-4057qib7 4311 3 is be VBZ cord-005453-4057qib7 4311 4 a a DT cord-005453-4057qib7 4311 5 fairly fairly RB cord-005453-4057qib7 4311 6 common common JJ cord-005453-4057qib7 4311 7 complication complication NN cord-005453-4057qib7 4311 8 in in IN cord-005453-4057qib7 4311 9 HSCT HSCT NNP cord-005453-4057qib7 4311 10 recipients recipient NNS cord-005453-4057qib7 4311 11 . . . cord-005453-4057qib7 4312 1 Similar similar JJ cord-005453-4057qib7 4312 2 to to IN cord-005453-4057qib7 4312 3 findings finding NNS cord-005453-4057qib7 4312 4 reported report VBN cord-005453-4057qib7 4312 5 in in IN cord-005453-4057qib7 4312 6 previous previous JJ cord-005453-4057qib7 4312 7 studies study NNS cord-005453-4057qib7 4312 8 , , , cord-005453-4057qib7 4312 9 association association NN cord-005453-4057qib7 4312 10 between between IN cord-005453-4057qib7 4312 11 allogeneic allogeneic NN cord-005453-4057qib7 4312 12 stem stem NN cord-005453-4057qib7 4312 13 cell cell NN cord-005453-4057qib7 4312 14 transplantation transplantation NN cord-005453-4057qib7 4312 15 , , , cord-005453-4057qib7 4312 16 therapy therapy NN cord-005453-4057qib7 4312 17 with with IN cord-005453-4057qib7 4312 18 calcineurin calcineurin NNP cord-005453-4057qib7 4312 19 inhibitors inhibitor NNS cord-005453-4057qib7 4312 20 , , , cord-005453-4057qib7 4312 21 and and CC cord-005453-4057qib7 4312 22 acute acute JJ cord-005453-4057qib7 4312 23 and and CC cord-005453-4057qib7 4312 24 chronic chronic JJ cord-005453-4057qib7 4312 25 GvHD gvhd NN cord-005453-4057qib7 4312 26 , , , cord-005453-4057qib7 4312 27 and and CC cord-005453-4057qib7 4312 28 post post JJ cord-005453-4057qib7 4312 29 - - JJ cord-005453-4057qib7 4312 30 HSCT hsct JJ cord-005453-4057qib7 4312 31 hypertension hypertension NN cord-005453-4057qib7 4312 32 was be VBD cord-005453-4057qib7 4312 33 found find VBN cord-005453-4057qib7 4312 34 in in IN cord-005453-4057qib7 4312 35 the the DT cord-005453-4057qib7 4312 36 present present JJ cord-005453-4057qib7 4312 37 cohort cohort NN cord-005453-4057qib7 4312 38 . . . cord-005453-4057qib7 4313 1 Further further JJ cord-005453-4057qib7 4313 2 studies study NNS cord-005453-4057qib7 4313 3 are be VBP cord-005453-4057qib7 4313 4 needed need VBN cord-005453-4057qib7 4313 5 to to TO cord-005453-4057qib7 4313 6 assess assess VB cord-005453-4057qib7 4313 7 the the DT cord-005453-4057qib7 4313 8 link link NN cord-005453-4057qib7 4313 9 between between IN cord-005453-4057qib7 4313 10 HSCT HSCT NNP cord-005453-4057qib7 4313 11 and and CC cord-005453-4057qib7 4313 12 developing develop VBG cord-005453-4057qib7 4313 13 long long JJ cord-005453-4057qib7 4313 14 - - HYPH cord-005453-4057qib7 4313 15 term term NN cord-005453-4057qib7 4313 16 cardiovascular cardiovascular JJ cord-005453-4057qib7 4313 17 complications complication NNS cord-005453-4057qib7 4313 18 . . . cord-005453-4057qib7 4314 1 Disclosure disclosure NN cord-005453-4057qib7 4314 2 : : : cord-005453-4057qib7 4314 3 Nothing nothing NN cord-005453-4057qib7 4314 4 to to TO cord-005453-4057qib7 4314 5 declare declare VB cord-005453-4057qib7 4314 6 Tramadol Tramadol NNP cord-005453-4057qib7 4314 7 - - HYPH cord-005453-4057qib7 4314 8 based base VBN cord-005453-4057qib7 4314 9 pain pain NN cord-005453-4057qib7 4314 10 management management NN cord-005453-4057qib7 4314 11 of of IN cord-005453-4057qib7 4314 12 oral oral JJ cord-005453-4057qib7 4314 13 and and CC cord-005453-4057qib7 4314 14 esophageal esophageal JJ cord-005453-4057qib7 4314 15 mucositis mucositis NN cord-005453-4057qib7 4314 16 in in IN cord-005453-4057qib7 4314 17 pediatric pediatric JJ cord-005453-4057qib7 4314 18 HSCT HSCT NNP cord-005453-4057qib7 4314 19 recipients recipient NNS cord-005453-4057qib7 4314 20 Background Background NNP cord-005453-4057qib7 4314 21 : : : cord-005453-4057qib7 4314 22 Mucositis Mucositis NNP cord-005453-4057qib7 4314 23 is be VBZ cord-005453-4057qib7 4314 24 one one CD cord-005453-4057qib7 4314 25 of of IN cord-005453-4057qib7 4314 26 the the DT cord-005453-4057qib7 4314 27 most most RBS cord-005453-4057qib7 4314 28 common common JJ cord-005453-4057qib7 4314 29 early early JJ cord-005453-4057qib7 4314 30 HSCT HSCT NNP cord-005453-4057qib7 4314 31 complications complication NNS cord-005453-4057qib7 4314 32 seen see VBN cord-005453-4057qib7 4314 33 in in IN cord-005453-4057qib7 4314 34 about about RB cord-005453-4057qib7 4314 35 70 70 CD cord-005453-4057qib7 4314 36 % % NN cord-005453-4057qib7 4314 37 transplant transplant NN cord-005453-4057qib7 4314 38 recipients recipient NNS cord-005453-4057qib7 4314 39 with with IN cord-005453-4057qib7 4314 40 20 20 CD cord-005453-4057qib7 4314 41 % % NN cord-005453-4057qib7 4314 42 of of IN cord-005453-4057qib7 4314 43 patients patient NNS cord-005453-4057qib7 4314 44 developing develop VBG cord-005453-4057qib7 4314 45 Gr Gr NNP cord-005453-4057qib7 4314 46 III III NNP cord-005453-4057qib7 4314 47 - - HYPH cord-005453-4057qib7 4314 48 IV IV NNP cord-005453-4057qib7 4314 49 mucositis mucositis NNP cord-005453-4057qib7 4314 50 . . . cord-005453-4057qib7 4315 1 Mucositis Mucositis NNP cord-005453-4057qib7 4315 2 is be VBZ cord-005453-4057qib7 4315 3 characterized characterize VBN cord-005453-4057qib7 4315 4 by by IN cord-005453-4057qib7 4315 5 painful painful JJ cord-005453-4057qib7 4315 6 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 4315 7 mucosa mucosa JJ cord-005453-4057qib7 4315 8 lesions lesion NNS cord-005453-4057qib7 4315 9 impairing impair VBG cord-005453-4057qib7 4315 10 the the DT cord-005453-4057qib7 4315 11 solid solid JJ cord-005453-4057qib7 4315 12 and and CC cord-005453-4057qib7 4315 13 liquid liquid JJ cord-005453-4057qib7 4315 14 foods food NNS cord-005453-4057qib7 4315 15 intake intake NN cord-005453-4057qib7 4315 16 and and CC cord-005453-4057qib7 4315 17 increased increase VBN cord-005453-4057qib7 4315 18 risk risk NN cord-005453-4057qib7 4315 19 of of IN cord-005453-4057qib7 4315 20 infections infection NNS cord-005453-4057qib7 4315 21 , , , cord-005453-4057qib7 4315 22 bleeding bleed VBG cord-005453-4057qib7 4315 23 , , , cord-005453-4057qib7 4315 24 and and CC cord-005453-4057qib7 4315 25 intestinal intestinal JJ cord-005453-4057qib7 4315 26 paresis paresis NN cord-005453-4057qib7 4315 27 . . . cord-005453-4057qib7 4316 1 Thus thus RB cord-005453-4057qib7 4316 2 , , , cord-005453-4057qib7 4316 3 it -PRON- PRP cord-005453-4057qib7 4316 4 greatly greatly RB cord-005453-4057qib7 4316 5 decreases decrease VBZ cord-005453-4057qib7 4316 6 the the DT cord-005453-4057qib7 4316 7 quality quality NN cord-005453-4057qib7 4316 8 of of IN cord-005453-4057qib7 4316 9 life life NN cord-005453-4057qib7 4316 10 of of IN cord-005453-4057qib7 4316 11 a a DT cord-005453-4057qib7 4316 12 transplant transplant NN cord-005453-4057qib7 4316 13 recipient recipient NN cord-005453-4057qib7 4316 14 . . . cord-005453-4057qib7 4317 1 According accord VBG cord-005453-4057qib7 4317 2 to to IN cord-005453-4057qib7 4317 3 WHO WHO NNP cord-005453-4057qib7 4317 4 recommendations recommendation NNS cord-005453-4057qib7 4317 5 , , , cord-005453-4057qib7 4317 6 the the DT cord-005453-4057qib7 4317 7 moderate moderate JJ cord-005453-4057qib7 4317 8 pain pain NN cord-005453-4057qib7 4317 9 control control NN cord-005453-4057qib7 4317 10 in in IN cord-005453-4057qib7 4317 11 pediatric pediatric JJ cord-005453-4057qib7 4317 12 patient patient NN cord-005453-4057qib7 4317 13 is be VBZ cord-005453-4057qib7 4317 14 based base VBN cord-005453-4057qib7 4317 15 on on IN cord-005453-4057qib7 4317 16 the the DT cord-005453-4057qib7 4317 17 use use NN cord-005453-4057qib7 4317 18 of of IN cord-005453-4057qib7 4317 19 low low JJ cord-005453-4057qib7 4317 20 - - HYPH cord-005453-4057qib7 4317 21 dose dose NN cord-005453-4057qib7 4317 22 morphine morphine NN cord-005453-4057qib7 4317 23 . . . cord-005453-4057qib7 4318 1 However however RB cord-005453-4057qib7 4318 2 , , , cord-005453-4057qib7 4318 3 there there EX cord-005453-4057qib7 4318 4 are be VBP cord-005453-4057qib7 4318 5 some some DT cord-005453-4057qib7 4318 6 factors factor NNS cord-005453-4057qib7 4318 7 such such JJ cord-005453-4057qib7 4318 8 as as IN cord-005453-4057qib7 4318 9 genetic genetic JJ cord-005453-4057qib7 4318 10 polymorphisms polymorphism NNS cord-005453-4057qib7 4318 11 causing cause VBG cord-005453-4057qib7 4318 12 variable variable JJ cord-005453-4057qib7 4318 13 morphine morphine NN cord-005453-4057qib7 4318 14 pharmacokinetics pharmacokinetic NNS cord-005453-4057qib7 4318 15 in in IN cord-005453-4057qib7 4318 16 children child NNS cord-005453-4057qib7 4318 17 , , , cord-005453-4057qib7 4318 18 side side NN cord-005453-4057qib7 4318 19 effects effect NNS cord-005453-4057qib7 4318 20 , , , cord-005453-4057qib7 4318 21 and and CC cord-005453-4057qib7 4318 22 social social JJ cord-005453-4057qib7 4318 23 factors factor NNS cord-005453-4057qib7 4318 24 ( ( -LRB- cord-005453-4057qib7 4318 25 caregivers caregiver NNS cord-005453-4057qib7 4318 26 ' ' POS cord-005453-4057qib7 4318 27 general general JJ cord-005453-4057qib7 4318 28 unwillingness unwillingness NN cord-005453-4057qib7 4318 29 to to TO cord-005453-4057qib7 4318 30 use use VB cord-005453-4057qib7 4318 31 narcotic narcotic JJ cord-005453-4057qib7 4318 32 analgesics analgesic NNS cord-005453-4057qib7 4318 33 ) ) -RRB- cord-005453-4057qib7 4318 34 , , , cord-005453-4057qib7 4318 35 which which WDT cord-005453-4057qib7 4318 36 cause cause VBP cord-005453-4057qib7 4318 37 the the DT cord-005453-4057qib7 4318 38 need need NN cord-005453-4057qib7 4318 39 for for IN cord-005453-4057qib7 4318 40 alternative alternative JJ cord-005453-4057qib7 4318 41 pain pain NN cord-005453-4057qib7 4318 42 relief relief NN cord-005453-4057qib7 4318 43 options option NNS cord-005453-4057qib7 4318 44 in in IN cord-005453-4057qib7 4318 45 pediatric pediatric JJ cord-005453-4057qib7 4318 46 practice practice NN cord-005453-4057qib7 4318 47 . . . cord-005453-4057qib7 4319 1 Tramadol Tramadol NNP cord-005453-4057qib7 4319 2 , , , cord-005453-4057qib7 4319 3 which which WDT cord-005453-4057qib7 4319 4 has have VBZ cord-005453-4057qib7 4319 5 both both DT cord-005453-4057qib7 4319 6 opioid opioid JJ cord-005453-4057qib7 4319 7 and and CC cord-005453-4057qib7 4319 8 non non JJ cord-005453-4057qib7 4319 9 - - JJ cord-005453-4057qib7 4319 10 opioid opioid JJ cord-005453-4057qib7 4319 11 mechanisms mechanism NNS cord-005453-4057qib7 4319 12 of of IN cord-005453-4057qib7 4319 13 action action NN cord-005453-4057qib7 4319 14 , , , cord-005453-4057qib7 4319 15 may may MD cord-005453-4057qib7 4319 16 be be VB cord-005453-4057qib7 4319 17 a a DT cord-005453-4057qib7 4319 18 feasible feasible JJ cord-005453-4057qib7 4319 19 option option NN cord-005453-4057qib7 4319 20 in in IN cord-005453-4057qib7 4319 21 mild mild JJ cord-005453-4057qib7 4319 22 to to IN cord-005453-4057qib7 4319 23 moderate moderate JJ cord-005453-4057qib7 4319 24 pain pain NN cord-005453-4057qib7 4319 25 . . . cord-005453-4057qib7 4320 1 It -PRON- PRP cord-005453-4057qib7 4320 2 may may MD cord-005453-4057qib7 4320 3 be be VB cord-005453-4057qib7 4320 4 delivered deliver VBN cord-005453-4057qib7 4320 5 via via IN cord-005453-4057qib7 4320 6 patient patient NN cord-005453-4057qib7 4320 7 - - HYPH cord-005453-4057qib7 4320 8 controlled control VBN cord-005453-4057qib7 4320 9 analgesia analgesia NN cord-005453-4057qib7 4320 10 ( ( -LRB- cord-005453-4057qib7 4320 11 PCA PCA NNP cord-005453-4057qib7 4320 12 ) ) -RRB- cord-005453-4057qib7 4320 13 , , , cord-005453-4057qib7 4320 14 although although IN cord-005453-4057qib7 4320 15 there there EX cord-005453-4057qib7 4320 16 is be VBZ cord-005453-4057qib7 4320 17 no no DT cord-005453-4057qib7 4320 18 consensus consensus NN cord-005453-4057qib7 4320 19 on on IN cord-005453-4057qib7 4320 20 its -PRON- PRP$ cord-005453-4057qib7 4320 21 optimal optimal JJ cord-005453-4057qib7 4320 22 parameters parameter NNS cord-005453-4057qib7 4320 23 in in IN cord-005453-4057qib7 4320 24 pediatric pediatric JJ cord-005453-4057qib7 4320 25 practice practice NN cord-005453-4057qib7 4320 26 . . . cord-005453-4057qib7 4321 1 Methods method NNS cord-005453-4057qib7 4321 2 : : : cord-005453-4057qib7 4321 3 A a DT cord-005453-4057qib7 4321 4 total total NN cord-005453-4057qib7 4321 5 of of IN cord-005453-4057qib7 4321 6 69 69 CD cord-005453-4057qib7 4321 7 pediatric pediatric JJ cord-005453-4057qib7 4321 8 patients patient NNS cord-005453-4057qib7 4321 9 with with IN cord-005453-4057qib7 4321 10 a a DT cord-005453-4057qib7 4321 11 median median JJ cord-005453-4057qib7 4321 12 age age NN cord-005453-4057qib7 4321 13 of of IN cord-005453-4057qib7 4321 14 8 8 CD cord-005453-4057qib7 4321 15 ( ( -LRB- cord-005453-4057qib7 4321 16 range range NN cord-005453-4057qib7 4321 17 2 2 CD cord-005453-4057qib7 4321 18 to to IN cord-005453-4057qib7 4321 19 18 18 CD cord-005453-4057qib7 4321 20 ) ) -RRB- cord-005453-4057qib7 4321 21 years year NNS cord-005453-4057qib7 4321 22 receiving receive VBG cord-005453-4057qib7 4321 23 an an DT cord-005453-4057qib7 4321 24 autologous autologous JJ cord-005453-4057qib7 4321 25 or or CC cord-005453-4057qib7 4321 26 allogeneic allogeneic IN cord-005453-4057qib7 4321 27 HSCT HSCT NNP cord-005453-4057qib7 4321 28 in in IN cord-005453-4057qib7 4321 29 our -PRON- PRP$ cord-005453-4057qib7 4321 30 clinic clinic NN cord-005453-4057qib7 4321 31 as as IN cord-005453-4057qib7 4321 32 part part NN cord-005453-4057qib7 4321 33 of of IN cord-005453-4057qib7 4321 34 the the DT cord-005453-4057qib7 4321 35 treatment treatment NN cord-005453-4057qib7 4321 36 regimen regimen NN cord-005453-4057qib7 4321 37 for for IN cord-005453-4057qib7 4321 38 solid solid JJ cord-005453-4057qib7 4321 39 tumor tumor NN cord-005453-4057qib7 4321 40 ( ( -LRB- cord-005453-4057qib7 4321 41 n=40 n=40 NNP cord-005453-4057qib7 4321 42 ) ) -RRB- cord-005453-4057qib7 4321 43 , , , cord-005453-4057qib7 4321 44 leukemia leukemia NN cord-005453-4057qib7 4321 45 ( ( -LRB- cord-005453-4057qib7 4321 46 n=24 n=24 NNP cord-005453-4057qib7 4321 47 ) ) -RRB- cord-005453-4057qib7 4321 48 , , , cord-005453-4057qib7 4321 49 acquired acquire VBD cord-005453-4057qib7 4321 50 aplastic aplastic JJ cord-005453-4057qib7 4321 51 anemia anemia NN cord-005453-4057qib7 4321 52 ( ( -LRB- cord-005453-4057qib7 4321 53 n=3 n=3 NN cord-005453-4057qib7 4321 54 ) ) -RRB- cord-005453-4057qib7 4321 55 or or CC cord-005453-4057qib7 4321 56 inherited inherit VBN cord-005453-4057qib7 4321 57 condition condition NN cord-005453-4057qib7 4321 58 ( ( -LRB- cord-005453-4057qib7 4321 59 n=2 n=2 NNS cord-005453-4057qib7 4321 60 ) ) -RRB- cord-005453-4057qib7 4321 61 were be VBD cord-005453-4057qib7 4321 62 included include VBN cord-005453-4057qib7 4321 63 . . . cord-005453-4057qib7 4322 1 Conditioning conditioning NN cord-005453-4057qib7 4322 2 regimens regimen NNS cord-005453-4057qib7 4322 3 were be VBD cord-005453-4057qib7 4322 4 myeloablative myeloablative NNP cord-005453-4057qib7 4322 5 ( ( -LRB- cord-005453-4057qib7 4322 6 MAC MAC NNP cord-005453-4057qib7 4322 7 ) ) -RRB- cord-005453-4057qib7 4322 8 in in IN cord-005453-4057qib7 4322 9 54 54 CD cord-005453-4057qib7 4322 10 and and CC cord-005453-4057qib7 4322 11 reduced reduce VBN cord-005453-4057qib7 4322 12 - - HYPH cord-005453-4057qib7 4322 13 intensity intensity NN cord-005453-4057qib7 4322 14 ( ( -LRB- cord-005453-4057qib7 4322 15 RIC RIC NNP cord-005453-4057qib7 4322 16 ) ) -RRB- cord-005453-4057qib7 4322 17 in in IN cord-005453-4057qib7 4322 18 15 15 CD cord-005453-4057qib7 4322 19 patients patient NNS cord-005453-4057qib7 4322 20 . . . cord-005453-4057qib7 4323 1 All all DT cord-005453-4057qib7 4323 2 patients patient NNS cord-005453-4057qib7 4323 3 had have VBD cord-005453-4057qib7 4323 4 oral oral JJ cord-005453-4057qib7 4323 5 and/or and/or CC cord-005453-4057qib7 4323 6 esophageal esophageal JJ cord-005453-4057qib7 4323 7 mucositis mucositis NN cord-005453-4057qib7 4323 8 accompanied accompany VBN cord-005453-4057qib7 4323 9 by by IN cord-005453-4057qib7 4323 10 moderate moderate JJ cord-005453-4057qib7 4323 11 pain pain NN cord-005453-4057qib7 4323 12 . . . cord-005453-4057qib7 4324 1 The the DT cord-005453-4057qib7 4324 2 pain pain NN cord-005453-4057qib7 4324 3 severity severity NN cord-005453-4057qib7 4324 4 was be VBD cord-005453-4057qib7 4324 5 assessed assess VBN cord-005453-4057qib7 4324 6 using use VBG cord-005453-4057qib7 4324 7 the the DT cord-005453-4057qib7 4324 8 scales scale NNS cord-005453-4057qib7 4324 9 corresponding correspond VBG cord-005453-4057qib7 4324 10 to to IN cord-005453-4057qib7 4324 11 patient patient NN cord-005453-4057qib7 4324 12 's 's POS cord-005453-4057qib7 4324 13 age age NN cord-005453-4057qib7 4324 14 and and CC cord-005453-4057qib7 4324 15 varied varied JJ cord-005453-4057qib7 4324 16 from from IN cord-005453-4057qib7 4324 17 3 3 CD cord-005453-4057qib7 4324 18 to to TO cord-005453-4057qib7 4324 19 6 6 CD cord-005453-4057qib7 4324 20 points point NNS cord-005453-4057qib7 4324 21 . . . cord-005453-4057qib7 4325 1 The the DT cord-005453-4057qib7 4325 2 pain pain NN cord-005453-4057qib7 4325 3 control control NN cord-005453-4057qib7 4325 4 was be VBD cord-005453-4057qib7 4325 5 based base VBN cord-005453-4057qib7 4325 6 on on IN cord-005453-4057qib7 4325 7 intravenous intravenous JJ cord-005453-4057qib7 4325 8 tramadol tramadol NN cord-005453-4057qib7 4325 9 administration administration NN cord-005453-4057qib7 4325 10 using use VBG cord-005453-4057qib7 4325 11 patientcontrolled patientcontrolle VBN cord-005453-4057qib7 4325 12 analgesia analgesia NNP cord-005453-4057qib7 4325 13 ( ( -LRB- cord-005453-4057qib7 4325 14 PCA PCA NNP cord-005453-4057qib7 4325 15 ) ) -RRB- cord-005453-4057qib7 4325 16 approach approach NN cord-005453-4057qib7 4325 17 . . . cord-005453-4057qib7 4326 1 The the DT cord-005453-4057qib7 4326 2 following follow VBG cord-005453-4057qib7 4326 3 PCA PCA NNP cord-005453-4057qib7 4326 4 parameters parameter NNS cord-005453-4057qib7 4326 5 were be VBD cord-005453-4057qib7 4326 6 used use VBN cord-005453-4057qib7 4326 7 : : : cord-005453-4057qib7 4326 8 loading loading NN cord-005453-4057qib7 4326 9 dose dose NN cord-005453-4057qib7 4326 10 of of IN cord-005453-4057qib7 4326 11 0.5 0.5 CD cord-005453-4057qib7 4326 12 mg mg NNP cord-005453-4057qib7 4326 13 / / SYM cord-005453-4057qib7 4326 14 kg kg NNP cord-005453-4057qib7 4326 15 ( ( -LRB- cord-005453-4057qib7 4326 16 not not RB cord-005453-4057qib7 4326 17 exceeding exceed VBG cord-005453-4057qib7 4326 18 25 25 CD cord-005453-4057qib7 4326 19 mg mg CD cord-005453-4057qib7 4326 20 ) ) -RRB- cord-005453-4057qib7 4326 21 , , , cord-005453-4057qib7 4326 22 basal basal NN cord-005453-4057qib7 4326 23 infusion infusion NN cord-005453-4057qib7 4326 24 rate rate NN cord-005453-4057qib7 4326 25 of of IN cord-005453-4057qib7 4326 26 0.25 0.25 CD cord-005453-4057qib7 4326 27 mg mg NN cord-005453-4057qib7 4326 28 / / SYM cord-005453-4057qib7 4326 29 kg kg NNP cord-005453-4057qib7 4326 30 ( ( -LRB- cord-005453-4057qib7 4326 31 not not RB cord-005453-4057qib7 4326 32 exceeding exceed VBG cord-005453-4057qib7 4326 33 12.5 12.5 CD cord-005453-4057qib7 4326 34 mg mg NNPS cord-005453-4057qib7 4326 35 ) ) -RRB- cord-005453-4057qib7 4326 36 , , , cord-005453-4057qib7 4326 37 a a DT cord-005453-4057qib7 4326 38 bolus bolus NN cord-005453-4057qib7 4326 39 of of IN cord-005453-4057qib7 4326 40 0.25 0.25 CD cord-005453-4057qib7 4326 41 mg mg NNP cord-005453-4057qib7 4326 42 / / SYM cord-005453-4057qib7 4326 43 kg kg NNP cord-005453-4057qib7 4326 44 ( ( -LRB- cord-005453-4057qib7 4326 45 not not RB cord-005453-4057qib7 4326 46 exceeding exceed VBG cord-005453-4057qib7 4326 47 12.5 12.5 CD cord-005453-4057qib7 4326 48 mg mg NNPS cord-005453-4057qib7 4326 49 ) ) -RRB- cord-005453-4057qib7 4326 50 , , , cord-005453-4057qib7 4326 51 lockout lockout NN cord-005453-4057qib7 4326 52 interval interval NN cord-005453-4057qib7 4326 53 of of IN cord-005453-4057qib7 4326 54 25 25 CD cord-005453-4057qib7 4326 55 min min NN cord-005453-4057qib7 4326 56 . . . cord-005453-4057qib7 4327 1 The the DT cord-005453-4057qib7 4327 2 maximal maximal JJ cord-005453-4057qib7 4327 3 daily daily JJ cord-005453-4057qib7 4327 4 dose dose NN cord-005453-4057qib7 4327 5 was be VBD cord-005453-4057qib7 4327 6 8 8 CD cord-005453-4057qib7 4327 7 mg mg NN cord-005453-4057qib7 4327 8 / / SYM cord-005453-4057qib7 4327 9 kg kg NNP cord-005453-4057qib7 4327 10 / / SYM cord-005453-4057qib7 4327 11 day day NN cord-005453-4057qib7 4327 12 . . . cord-005453-4057qib7 4328 1 The the DT cord-005453-4057qib7 4328 2 pain pain NN cord-005453-4057qib7 4328 3 control control NN cord-005453-4057qib7 4328 4 was be VBD cord-005453-4057qib7 4328 5 considered consider VBN cord-005453-4057qib7 4328 6 adequate adequate JJ cord-005453-4057qib7 4328 7 if if IN cord-005453-4057qib7 4328 8 a a DT cord-005453-4057qib7 4328 9 patient patient NN cord-005453-4057qib7 4328 10 was be VBD cord-005453-4057qib7 4328 11 satisfied satisfied JJ cord-005453-4057qib7 4328 12 or or CC cord-005453-4057qib7 4328 13 the the DT cord-005453-4057qib7 4328 14 basic basic JJ cord-005453-4057qib7 4328 15 and and CC cord-005453-4057qib7 4328 16 breakthrough breakthrough JJ cord-005453-4057qib7 4328 17 pain pain NN cord-005453-4057qib7 4328 18 score score NN cord-005453-4057qib7 4328 19 values value NNS cord-005453-4057qib7 4328 20 were be VBD cord-005453-4057qib7 4328 21 not not RB cord-005453-4057qib7 4328 22 higher high JJR cord-005453-4057qib7 4328 23 than than IN cord-005453-4057qib7 4328 24 3 3 CD cord-005453-4057qib7 4328 25 and and CC cord-005453-4057qib7 4328 26 , , , cord-005453-4057qib7 4328 27 accordingly accordingly RB cord-005453-4057qib7 4328 28 . . . cord-005453-4057qib7 4329 1 In in IN cord-005453-4057qib7 4329 2 case case NN cord-005453-4057qib7 4329 3 of of IN cord-005453-4057qib7 4329 4 inadequate inadequate JJ cord-005453-4057qib7 4329 5 pain pain NN cord-005453-4057qib7 4329 6 control control NN cord-005453-4057qib7 4329 7 NSAIDs NSAIDs NNPS cord-005453-4057qib7 4329 8 were be VBD cord-005453-4057qib7 4329 9 added add VBN cord-005453-4057qib7 4329 10 . . . cord-005453-4057qib7 4330 1 Non Non NNS cord-005453-4057qib7 4330 2 - - NNS cord-005453-4057qib7 4330 3 responders responder NNS cord-005453-4057qib7 4330 4 were be VBD cord-005453-4057qib7 4330 5 switched switch VBN cord-005453-4057qib7 4330 6 to to IN cord-005453-4057qib7 4330 7 morphine morphine NN cord-005453-4057qib7 4330 8 . . . cord-005453-4057qib7 4331 1 All all DT cord-005453-4057qib7 4331 2 patients patient NNS cord-005453-4057qib7 4331 3 were be VBD cord-005453-4057qib7 4331 4 divided divide VBN cord-005453-4057qib7 4331 5 into into IN cord-005453-4057qib7 4331 6 2 2 CD cord-005453-4057qib7 4331 7 groups group NNS cord-005453-4057qib7 4331 8 based base VBN cord-005453-4057qib7 4331 9 on on IN cord-005453-4057qib7 4331 10 conditioning conditioning NN cord-005453-4057qib7 4331 11 regimen regimen NN cord-005453-4057qib7 4331 12 intensity intensity NN cord-005453-4057qib7 4331 13 . . . cord-005453-4057qib7 4332 1 Results result NNS cord-005453-4057qib7 4332 2 : : : cord-005453-4057qib7 4333 1 As as IN cord-005453-4057qib7 4333 2 a a DT cord-005453-4057qib7 4333 3 whole whole NN cord-005453-4057qib7 4333 4 , , , cord-005453-4057qib7 4333 5 46 46 CD cord-005453-4057qib7 4333 6 % % NN cord-005453-4057qib7 4333 7 of of IN cord-005453-4057qib7 4333 8 patients patient NNS cord-005453-4057qib7 4333 9 did do VBD cord-005453-4057qib7 4333 10 not not RB cord-005453-4057qib7 4333 11 require require VB cord-005453-4057qib7 4333 12 pain pain NN cord-005453-4057qib7 4333 13 control control NN cord-005453-4057qib7 4333 14 measures measure NNS cord-005453-4057qib7 4333 15 escalation escalation NN cord-005453-4057qib7 4333 16 . . . cord-005453-4057qib7 4334 1 The the DT cord-005453-4057qib7 4334 2 tramadol tramadol NN cord-005453-4057qib7 4334 3 pain pain NN cord-005453-4057qib7 4334 4 control control NN cord-005453-4057qib7 4334 5 rate rate NN cord-005453-4057qib7 4334 6 was be VBD cord-005453-4057qib7 4334 7 slightly slightly RB cord-005453-4057qib7 4334 8 higher high JJR cord-005453-4057qib7 4334 9 for for IN cord-005453-4057qib7 4334 10 RIC RIC NNP cord-005453-4057qib7 4334 11 ( ( -LRB- cord-005453-4057qib7 4334 12 n=9 n=9 NN cord-005453-4057qib7 4334 13 , , , cord-005453-4057qib7 4334 14 60 60 CD cord-005453-4057qib7 4334 15 % % NN cord-005453-4057qib7 4334 16 ) ) -RRB- cord-005453-4057qib7 4334 17 compared compare VBN cord-005453-4057qib7 4334 18 to to IN cord-005453-4057qib7 4334 19 MAC MAC NNP cord-005453-4057qib7 4334 20 ( ( -LRB- cord-005453-4057qib7 4334 21 n=23 n=23 UH cord-005453-4057qib7 4334 22 , , , cord-005453-4057qib7 4334 23 47 47 CD cord-005453-4057qib7 4334 24 % % NN cord-005453-4057qib7 4334 25 ) ) -RRB- cord-005453-4057qib7 4334 26 recipients recipient NNS cord-005453-4057qib7 4334 27 . . . cord-005453-4057qib7 4335 1 In in IN cord-005453-4057qib7 4335 2 most most JJS cord-005453-4057qib7 4335 3 cases case NNS cord-005453-4057qib7 4335 4 the the DT cord-005453-4057qib7 4335 5 inadequate inadequate JJ cord-005453-4057qib7 4335 6 pain pain NN cord-005453-4057qib7 4335 7 control control NN cord-005453-4057qib7 4335 8 was be VBD cord-005453-4057qib7 4335 9 due due JJ cord-005453-4057qib7 4335 10 to to IN cord-005453-4057qib7 4335 11 progressive progressive JJ cord-005453-4057qib7 4335 12 mucosal mucosal JJ cord-005453-4057qib7 4335 13 lesions lesion NNS cord-005453-4057qib7 4335 14 . . . cord-005453-4057qib7 4336 1 The the DT cord-005453-4057qib7 4336 2 PCA PCA NNP cord-005453-4057qib7 4336 3 regimen regimen NN cord-005453-4057qib7 4336 4 used use VBN cord-005453-4057qib7 4336 5 was be VBD cord-005453-4057qib7 4336 6 characterized characterize VBN cord-005453-4057qib7 4336 7 by by IN cord-005453-4057qib7 4336 8 very very RB cord-005453-4057qib7 4336 9 few few JJ cord-005453-4057qib7 4336 10 complications complication NNS cord-005453-4057qib7 4336 11 . . . cord-005453-4057qib7 4337 1 Drowsiness drowsiness NN cord-005453-4057qib7 4337 2 was be VBD cord-005453-4057qib7 4337 3 observed observe VBN cord-005453-4057qib7 4337 4 in in IN cord-005453-4057qib7 4337 5 4 4 CD cord-005453-4057qib7 4337 6 ( ( -LRB- cord-005453-4057qib7 4337 7 7 7 CD cord-005453-4057qib7 4337 8 % % NN cord-005453-4057qib7 4337 9 ) ) -RRB- cord-005453-4057qib7 4337 10 of of IN cord-005453-4057qib7 4337 11 patients patient NNS cord-005453-4057qib7 4337 12 , , , cord-005453-4057qib7 4337 13 in in IN cord-005453-4057qib7 4337 14 all all DT cord-005453-4057qib7 4337 15 cases case NNS cord-005453-4057qib7 4337 16 the the DT cord-005453-4057qib7 4337 17 patients patient NNS cord-005453-4057qib7 4337 18 also also RB cord-005453-4057qib7 4337 19 had have VBD cord-005453-4057qib7 4337 20 anemia anemia NN cord-005453-4057qib7 4337 21 . . . cord-005453-4057qib7 4338 1 There there EX cord-005453-4057qib7 4338 2 was be VBD cord-005453-4057qib7 4338 3 only only RB cord-005453-4057qib7 4338 4 1 1 CD cord-005453-4057qib7 4338 5 ( ( -LRB- cord-005453-4057qib7 4338 6 7 7 CD cord-005453-4057qib7 4338 7 % % NN cord-005453-4057qib7 4338 8 ) ) -RRB- cord-005453-4057qib7 4338 9 patients patient NNS cord-005453-4057qib7 4338 10 with with IN cord-005453-4057qib7 4338 11 severe severe JJ cord-005453-4057qib7 4338 12 nausea nausea NN cord-005453-4057qib7 4338 13 requiring require VBG cord-005453-4057qib7 4338 14 switching switch VBG cord-005453-4057qib7 4338 15 to to IN cord-005453-4057qib7 4338 16 morphine morphine NN cord-005453-4057qib7 4338 17 . . . cord-005453-4057qib7 4339 1 Conclusions conclusion NNS cord-005453-4057qib7 4339 2 : : : cord-005453-4057qib7 4340 1 Tramadol Tramadol NNP cord-005453-4057qib7 4340 2 is be VBZ cord-005453-4057qib7 4340 3 an an DT cord-005453-4057qib7 4340 4 effective effective JJ cord-005453-4057qib7 4340 5 pain pain NN cord-005453-4057qib7 4340 6 control control NN cord-005453-4057qib7 4340 7 option option NN cord-005453-4057qib7 4340 8 in in IN cord-005453-4057qib7 4340 9 transplant transplant NN cord-005453-4057qib7 4340 10 recipients recipient NNS cord-005453-4057qib7 4340 11 with with IN cord-005453-4057qib7 4340 12 mild mild JJ cord-005453-4057qib7 4340 13 to to IN cord-005453-4057qib7 4340 14 moderate moderate JJ cord-005453-4057qib7 4340 15 pain pain NN cord-005453-4057qib7 4340 16 due due IN cord-005453-4057qib7 4340 17 to to IN cord-005453-4057qib7 4340 18 oral oral JJ cord-005453-4057qib7 4340 19 and and CC cord-005453-4057qib7 4340 20 esophageal esophageal JJ cord-005453-4057qib7 4340 21 mucositis mucositis NN cord-005453-4057qib7 4340 22 without without IN cord-005453-4057qib7 4340 23 progressive progressive JJ cord-005453-4057qib7 4340 24 mucosal mucosal JJ cord-005453-4057qib7 4340 25 lesions lesion NNS cord-005453-4057qib7 4340 26 . . . cord-005453-4057qib7 4341 1 The the DT cord-005453-4057qib7 4341 2 PCA PCA NNP cord-005453-4057qib7 4341 3 allows allow VBZ cord-005453-4057qib7 4341 4 achieving achieve VBG cord-005453-4057qib7 4341 5 a a DT cord-005453-4057qib7 4341 6 very very RB cord-005453-4057qib7 4341 7 low low JJ cord-005453-4057qib7 4341 8 complication complication NN cord-005453-4057qib7 4341 9 rate rate NN cord-005453-4057qib7 4341 10 . . . cord-005453-4057qib7 4342 1 Therefore therefore RB cord-005453-4057qib7 4342 2 , , , cord-005453-4057qib7 4342 3 this this DT cord-005453-4057qib7 4342 4 option option NN cord-005453-4057qib7 4342 5 may may MD cord-005453-4057qib7 4342 6 be be VB cord-005453-4057qib7 4342 7 considered consider VBN cord-005453-4057qib7 4342 8 for for IN cord-005453-4057qib7 4342 9 both both CC cord-005453-4057qib7 4342 10 MAC MAC NNP cord-005453-4057qib7 4342 11 and and CC cord-005453-4057qib7 4342 12 RIC RIC NNP cord-005453-4057qib7 4342 13 recipients recipient NNS cord-005453-4057qib7 4342 14 . . . cord-005453-4057qib7 4343 1 Disclosure disclosure NN cord-005453-4057qib7 4343 2 : : : cord-005453-4057qib7 4343 3 No no DT cord-005453-4057qib7 4343 4 Immune Immune NNP cord-005453-4057qib7 4343 5 reconstitution reconstitution NN cord-005453-4057qib7 4343 6 of of IN cord-005453-4057qib7 4343 7 lymphocyte lymphocyte NN cord-005453-4057qib7 4343 8 subsets subset NNS cord-005453-4057qib7 4343 9 after after IN cord-005453-4057qib7 4343 10 allogenic allogenic JJ cord-005453-4057qib7 4343 11 stem stem NN cord-005453-4057qib7 4343 12 cell cell NN cord-005453-4057qib7 4343 13 transplant transplant NN cord-005453-4057qib7 4343 14 ( ( -LRB- cord-005453-4057qib7 4343 15 SCT SCT NNP cord-005453-4057qib7 4343 16 ) ) -RRB- cord-005453-4057qib7 4343 17 and and CC cord-005453-4057qib7 4343 18 vaccination vaccination NN cord-005453-4057qib7 4343 19 Background background NN cord-005453-4057qib7 4343 20 : : : cord-005453-4057qib7 4344 1 Infectious infectious JJ cord-005453-4057qib7 4344 2 diseases disease NNS cord-005453-4057qib7 4344 3 are be VBP cord-005453-4057qib7 4344 4 a a DT cord-005453-4057qib7 4344 5 major major JJ cord-005453-4057qib7 4344 6 cause cause NN cord-005453-4057qib7 4344 7 of of IN cord-005453-4057qib7 4344 8 morbidity morbidity NN cord-005453-4057qib7 4344 9 and and CC cord-005453-4057qib7 4344 10 mortality mortality NN cord-005453-4057qib7 4344 11 after after IN cord-005453-4057qib7 4344 12 allogenic allogenic JJ cord-005453-4057qib7 4344 13 stem stem NN cord-005453-4057qib7 4344 14 cell cell NN cord-005453-4057qib7 4344 15 transplant transplant NN cord-005453-4057qib7 4344 16 ( ( -LRB- cord-005453-4057qib7 4344 17 SCT SCT NNP cord-005453-4057qib7 4344 18 ) ) -RRB- cord-005453-4057qib7 4344 19 . . . cord-005453-4057qib7 4345 1 Vaccines vaccine NNS cord-005453-4057qib7 4345 2 constitute constitute VBP cord-005453-4057qib7 4345 3 an an DT cord-005453-4057qib7 4345 4 effective effective JJ cord-005453-4057qib7 4345 5 strategy strategy NN cord-005453-4057qib7 4345 6 to to TO cord-005453-4057qib7 4345 7 prevent prevent VB cord-005453-4057qib7 4345 8 infections infection NNS cord-005453-4057qib7 4345 9 but but CC cord-005453-4057qib7 4345 10 the the DT cord-005453-4057qib7 4345 11 optimal optimal JJ cord-005453-4057qib7 4345 12 timing timing NN cord-005453-4057qib7 4345 13 to to TO cord-005453-4057qib7 4345 14 start start VB cord-005453-4057qib7 4345 15 vaccinating vaccinate VBG cord-005453-4057qib7 4345 16 is be VBZ cord-005453-4057qib7 4345 17 not not RB cord-005453-4057qib7 4345 18 well well RB cord-005453-4057qib7 4345 19 stablished stablishe VBN cord-005453-4057qib7 4345 20 . . . cord-005453-4057qib7 4346 1 In in IN cord-005453-4057qib7 4346 2 order order NN cord-005453-4057qib7 4346 3 to to TO cord-005453-4057qib7 4346 4 individualize individualize VB cord-005453-4057qib7 4346 5 the the DT cord-005453-4057qib7 4346 6 early early JJ cord-005453-4057qib7 4346 7 vaccination vaccination NN cord-005453-4057qib7 4346 8 schedule schedule NN cord-005453-4057qib7 4346 9 , , , cord-005453-4057qib7 4346 10 we -PRON- PRP cord-005453-4057qib7 4346 11 studied study VBD cord-005453-4057qib7 4346 12 the the DT cord-005453-4057qib7 4346 13 lymphocyte lymphocyte NN cord-005453-4057qib7 4346 14 subsets subset NNS cord-005453-4057qib7 4346 15 involved involve VBN cord-005453-4057qib7 4346 16 in in IN cord-005453-4057qib7 4346 17 generating generate VBG cord-005453-4057qib7 4346 18 enough enough JJ cord-005453-4057qib7 4346 19 response response NN cord-005453-4057qib7 4346 20 to to TO cord-005453-4057qib7 4346 21 produce produce VB cord-005453-4057qib7 4346 22 protective protective JJ cord-005453-4057qib7 4346 23 serological serological JJ cord-005453-4057qib7 4346 24 levels level NNS cord-005453-4057qib7 4346 25 . . . cord-005453-4057qib7 4347 1 Methods method NNS cord-005453-4057qib7 4347 2 : : : cord-005453-4057qib7 4347 3 We -PRON- PRP cord-005453-4057qib7 4347 4 studied study VBD cord-005453-4057qib7 4347 5 retrospectively retrospectively RB cord-005453-4057qib7 4347 6 20 20 CD cord-005453-4057qib7 4347 7 patients patient NNS cord-005453-4057qib7 4347 8 that that WDT cord-005453-4057qib7 4347 9 had have VBD cord-005453-4057qib7 4347 10 undergone undergo VBN cord-005453-4057qib7 4347 11 allogenic allogenic JJ cord-005453-4057qib7 4347 12 SCT SCT NNP cord-005453-4057qib7 4347 13 at at IN cord-005453-4057qib7 4347 14 our -PRON- PRP$ cord-005453-4057qib7 4347 15 hospital hospital NN cord-005453-4057qib7 4347 16 . . . cord-005453-4057qib7 4348 1 Patient patient JJ cord-005453-4057qib7 4348 2 distribution distribution NN cord-005453-4057qib7 4348 3 -Age -age NN cord-005453-4057qib7 4348 4 range range NN cord-005453-4057qib7 4348 5 : : : cord-005453-4057qib7 4348 6 21 21 CD cord-005453-4057qib7 4348 7 - - SYM cord-005453-4057qib7 4348 8 68 68 CD cord-005453-4057qib7 4348 9 years year NNS cord-005453-4057qib7 4348 10 - - HYPH cord-005453-4057qib7 4348 11 old old JJ cord-005453-4057qib7 4348 12 ; ; : cord-005453-4057qib7 4348 13 diagnosis diagnosis NN cord-005453-4057qib7 4348 14 : : : cord-005453-4057qib7 4348 15 acute acute JJ cord-005453-4057qib7 4348 16 leukaemia leukaemia NN cord-005453-4057qib7 4348 17 / / SYM cord-005453-4057qib7 4348 18 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 4348 19 syndrome/ syndrome/ CD cord-005453-4057qib7 4348 20 chronic chronic JJ cord-005453-4057qib7 4348 21 myeloid myeloid NN cord-005453-4057qib7 4348 22 leukemia leukemia NN cord-005453-4057qib7 4348 23 ( ( -LRB- cord-005453-4057qib7 4348 24 16 16 CD cord-005453-4057qib7 4348 25 patients patient NNS cord-005453-4057qib7 4348 26 ) ) -RRB- cord-005453-4057qib7 4348 27 , , , cord-005453-4057qib7 4348 28 lymphoma lymphoma NN cord-005453-4057qib7 4348 29 ( ( -LRB- cord-005453-4057qib7 4348 30 4 4 CD cord-005453-4057qib7 4348 31 patients patient NNS cord-005453-4057qib7 4348 32 ) ) -RRB- cord-005453-4057qib7 4348 33 . . . cord-005453-4057qib7 4349 1 Analytic analytic JJ cord-005453-4057qib7 4349 2 parameters parameter NNS cord-005453-4057qib7 4349 3 : : : cord-005453-4057qib7 4349 4 TCD4 TCD4 NNP cord-005453-4057qib7 4349 5 + + CC cord-005453-4057qib7 4349 6 , , , cord-005453-4057qib7 4349 7 TCD8 TCD8 NNP cord-005453-4057qib7 4349 8 + + SYM cord-005453-4057qib7 4349 9 , , , cord-005453-4057qib7 4349 10 NK NK NNP cord-005453-4057qib7 4349 11 , , , cord-005453-4057qib7 4349 12 total total JJ cord-005453-4057qib7 4349 13 B b NN cord-005453-4057qib7 4349 14 and and CC cord-005453-4057qib7 4349 15 functional functional JJ cord-005453-4057qib7 4349 16 B b NN cord-005453-4057qib7 4349 17 lymphocyte lymphocyte NN cord-005453-4057qib7 4349 18 subsets subset NNS cord-005453-4057qib7 4349 19 ( ( -LRB- cord-005453-4057qib7 4349 20 naïve naïve JJ cord-005453-4057qib7 4349 21 IgD+CD27- IgD+CD27- NNP cord-005453-4057qib7 4349 22 , , , cord-005453-4057qib7 4350 1 memory memory NN cord-005453-4057qib7 4351 1 IgD+CD27 igd+cd27 NN cord-005453-4057qib7 4352 1 + + CC cord-005453-4057qib7 4353 1 and and CC cord-005453-4057qib7 4353 2 IgD IgD NNP cord-005453-4057qib7 4353 3 - - : cord-005453-4057qib7 4353 4 CD27 CD27 NNP cord-005453-4057qib7 4353 5 + + CC cord-005453-4057qib7 4353 6 , , , cord-005453-4057qib7 4353 7 and and CC cord-005453-4057qib7 4353 8 effectors effector NNS cord-005453-4057qib7 4353 9 CD27++CD38++ cd27++cd38++ JJ cord-005453-4057qib7 4353 10 ) ) -RRB- cord-005453-4057qib7 4353 11 . . . cord-005453-4057qib7 4354 1 Immunoglobulin immunoglobulin NN cord-005453-4057qib7 4354 2 levels level NNS cord-005453-4057qib7 4354 3 ( ( -LRB- cord-005453-4057qib7 4354 4 IgG IgG NNP cord-005453-4057qib7 4354 5 , , , cord-005453-4057qib7 4354 6 IgA IgA NNP cord-005453-4057qib7 4354 7 , , , cord-005453-4057qib7 4354 8 IgM IgM NNP cord-005453-4057qib7 4354 9 ) ) -RRB- cord-005453-4057qib7 4354 10 and and CC cord-005453-4057qib7 4354 11 specific specific JJ cord-005453-4057qib7 4354 12 IgG igg NN cord-005453-4057qib7 4354 13 for for IN cord-005453-4057qib7 4354 14 pneumococcus pneumococcus NNP cord-005453-4057qib7 4354 15 , , , cord-005453-4057qib7 4354 16 tetanus tetanus NN cord-005453-4057qib7 4354 17 , , , cord-005453-4057qib7 4354 18 HBV HBV NNP cord-005453-4057qib7 4354 19 , , , cord-005453-4057qib7 4354 20 chickenpox chickenpox NN cord-005453-4057qib7 4354 21 , , , cord-005453-4057qib7 4354 22 measles measle NNS cord-005453-4057qib7 4354 23 , , , cord-005453-4057qib7 4354 24 rubella rubella NN cord-005453-4057qib7 4354 25 and and CC cord-005453-4057qib7 4354 26 mumps mump NNS cord-005453-4057qib7 4354 27 . . . cord-005453-4057qib7 4355 1 Clinical clinical JJ cord-005453-4057qib7 4355 2 parameters parameter NNS cord-005453-4057qib7 4355 3 were be VBD cord-005453-4057qib7 4355 4 collected collect VBN cord-005453-4057qib7 4355 5 from from IN cord-005453-4057qib7 4355 6 medical medical JJ cord-005453-4057qib7 4355 7 records record NNS cord-005453-4057qib7 4355 8 . . . cord-005453-4057qib7 4356 1 Results result NNS cord-005453-4057qib7 4356 2 : : : cord-005453-4057qib7 4357 1 We -PRON- PRP cord-005453-4057qib7 4357 2 distributed distribute VBD cord-005453-4057qib7 4357 3 patients patient NNS cord-005453-4057qib7 4357 4 in in IN cord-005453-4057qib7 4357 5 two two CD cord-005453-4057qib7 4357 6 groups group NNS cord-005453-4057qib7 4357 7 , , , cord-005453-4057qib7 4357 8 based base VBN cord-005453-4057qib7 4357 9 on on IN cord-005453-4057qib7 4357 10 the the DT cord-005453-4057qib7 4357 11 timing timing NN cord-005453-4057qib7 4357 12 of of IN cord-005453-4057qib7 4357 13 lymphocyte lymphocyte NN cord-005453-4057qib7 4357 14 analyses analysis NNS cord-005453-4057qib7 4357 15 : : : cord-005453-4057qib7 4357 16 -Less -less NN cord-005453-4057qib7 4357 17 than than IN cord-005453-4057qib7 4357 18 12 12 CD cord-005453-4057qib7 4357 19 months month NNS cord-005453-4057qib7 4357 20 since since IN cord-005453-4057qib7 4357 21 SCT SCT NNP cord-005453-4057qib7 4357 22 ( ( -LRB- cord-005453-4057qib7 4357 23 5 5 CD cord-005453-4057qib7 4357 24 patients patient NNS cord-005453-4057qib7 4357 25 ) ) -RRB- cord-005453-4057qib7 4358 1 No no DT cord-005453-4057qib7 4358 2 patient patient NN cord-005453-4057qib7 4358 3 showed show VBD cord-005453-4057qib7 4358 4 complete complete JJ cord-005453-4057qib7 4358 5 immune immune JJ cord-005453-4057qib7 4358 6 reconstitution reconstitution NN cord-005453-4057qib7 4358 7 , , , cord-005453-4057qib7 4358 8 although although IN cord-005453-4057qib7 4358 9 2 2 CD cord-005453-4057qib7 4358 10 had have VBD cord-005453-4057qib7 4358 11 enough enough JJ cord-005453-4057qib7 4358 12 T t NN cord-005453-4057qib7 4358 13 and and CC cord-005453-4057qib7 4358 14 functional functional JJ cord-005453-4057qib7 4358 15 B b NN cord-005453-4057qib7 4358 16 lymphocytes lymphocyte NNS cord-005453-4057qib7 4358 17 to to TO cord-005453-4057qib7 4358 18 generate generate VB cord-005453-4057qib7 4358 19 response response NN cord-005453-4057qib7 4358 20 to to IN cord-005453-4057qib7 4358 21 vaccination vaccination NN cord-005453-4057qib7 4358 22 . . . cord-005453-4057qib7 4359 1 In in IN cord-005453-4057qib7 4359 2 these these DT cord-005453-4057qib7 4359 3 patients patient NNS cord-005453-4057qib7 4359 4 , , , cord-005453-4057qib7 4359 5 vaccination vaccination NN cord-005453-4057qib7 4359 6 for for IN cord-005453-4057qib7 4359 7 pneumococcus pneumococcus NNP cord-005453-4057qib7 4359 8 was be VBD cord-005453-4057qib7 4359 9 completed complete VBN cord-005453-4057qib7 4359 10 and and CC cord-005453-4057qib7 4359 11 they -PRON- PRP cord-005453-4057qib7 4359 12 generated generate VBD cord-005453-4057qib7 4359 13 sufficient sufficient JJ cord-005453-4057qib7 4359 14 protection protection NN cord-005453-4057qib7 4359 15 antibody antibody NN cord-005453-4057qib7 4359 16 levels level NNS cord-005453-4057qib7 4359 17 , , , cord-005453-4057qib7 4359 18 despite despite IN cord-005453-4057qib7 4359 19 being be VBG cord-005453-4057qib7 4359 20 under under IN cord-005453-4057qib7 4359 21 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4359 22 treatment treatment NN cord-005453-4057qib7 4359 23 . . . cord-005453-4057qib7 4360 1 -More -More . cord-005453-4057qib7 4361 1 than than IN cord-005453-4057qib7 4361 2 12 12 CD cord-005453-4057qib7 4361 3 months month NNS cord-005453-4057qib7 4361 4 since since IN cord-005453-4057qib7 4361 5 SCT SCT NNP cord-005453-4057qib7 4361 6 ( ( -LRB- cord-005453-4057qib7 4361 7 15 15 CD cord-005453-4057qib7 4361 8 patients patient NNS cord-005453-4057qib7 4361 9 ) ) -RRB- cord-005453-4057qib7 4361 10 Before before IN cord-005453-4057qib7 4361 11 the the DT cord-005453-4057qib7 4361 12 beginning beginning NN cord-005453-4057qib7 4361 13 of of IN cord-005453-4057qib7 4361 14 vaccination vaccination NN cord-005453-4057qib7 4361 15 , , , cord-005453-4057qib7 4361 16 we -PRON- PRP cord-005453-4057qib7 4361 17 collected collect VBD cord-005453-4057qib7 4361 18 specific specific JJ cord-005453-4057qib7 4361 19 antibodies antibody NNS cord-005453-4057qib7 4361 20 of of IN cord-005453-4057qib7 4361 21 7 7 CD cord-005453-4057qib7 4361 22 patients patient NNS cord-005453-4057qib7 4361 23 . . . cord-005453-4057qib7 4362 1 We -PRON- PRP cord-005453-4057qib7 4362 2 compared compare VBD cord-005453-4057qib7 4362 3 the the DT cord-005453-4057qib7 4362 4 serological serological JJ cord-005453-4057qib7 4362 5 status status NN cord-005453-4057qib7 4362 6 before before IN cord-005453-4057qib7 4362 7 and and CC cord-005453-4057qib7 4362 8 after after IN cord-005453-4057qib7 4362 9 SCT SCT NNP cord-005453-4057qib7 4362 10 and and CC cord-005453-4057qib7 4362 11 observed observe VBD cord-005453-4057qib7 4362 12 that that IN cord-005453-4057qib7 4362 13 protection protection NN cord-005453-4057qib7 4362 14 against against IN cord-005453-4057qib7 4362 15 tetanus tetanus NN cord-005453-4057qib7 4362 16 was be VBD cord-005453-4057qib7 4362 17 the the DT cord-005453-4057qib7 4362 18 most most RBS cord-005453-4057qib7 4362 19 frequently frequently RB cord-005453-4057qib7 4362 20 preserved preserve VBN cord-005453-4057qib7 4362 21 ( ( -LRB- cord-005453-4057qib7 4362 22 6 6 CD cord-005453-4057qib7 4362 23 patients patient NNS cord-005453-4057qib7 4362 24 ) ) -RRB- cord-005453-4057qib7 4362 25 and and CC cord-005453-4057qib7 4362 26 HBV HBV NNP cord-005453-4057qib7 4362 27 the the DT cord-005453-4057qib7 4362 28 least least RBS cord-005453-4057qib7 4362 29 frequent frequent JJ cord-005453-4057qib7 4362 30 ( ( -LRB- cord-005453-4057qib7 4362 31 2 2 CD cord-005453-4057qib7 4362 32 patients patient NNS cord-005453-4057qib7 4362 33 ) ) -RRB- cord-005453-4057qib7 4362 34 . . . cord-005453-4057qib7 4363 1 Other other JJ cord-005453-4057qib7 4363 2 than than IN cord-005453-4057qib7 4363 3 one one CD cord-005453-4057qib7 4363 4 patient patient NN cord-005453-4057qib7 4363 5 treated treat VBN cord-005453-4057qib7 4363 6 with with IN cord-005453-4057qib7 4363 7 alemtuzumab alemtuzumab NNS cord-005453-4057qib7 4363 8 , , , cord-005453-4057qib7 4363 9 all all DT cord-005453-4057qib7 4363 10 patients patient NNS cord-005453-4057qib7 4363 11 in in IN cord-005453-4057qib7 4363 12 this this DT cord-005453-4057qib7 4363 13 group group NN cord-005453-4057qib7 4363 14 had have VBD cord-005453-4057qib7 4363 15 minimum minimum JJ cord-005453-4057qib7 4363 16 absolute absolute JJ cord-005453-4057qib7 4363 17 count count NN cord-005453-4057qib7 4363 18 of of IN cord-005453-4057qib7 4363 19 TCD4 TCD4 NNP cord-005453-4057qib7 4363 20 + + CC cord-005453-4057qib7 4363 21 ( ( -LRB- cord-005453-4057qib7 4363 22 > > NFP cord-005453-4057qib7 4363 23 200 200 CD cord-005453-4057qib7 4363 24 cells cell NNS cord-005453-4057qib7 4363 25 / / SYM cord-005453-4057qib7 4363 26 microl microl NNP cord-005453-4057qib7 4363 27 ) ) -RRB- cord-005453-4057qib7 4363 28 , , . cord-005453-4057qib7 4364 1 TCD8 TCD8 NNP cord-005453-4057qib7 4364 2 + + CC cord-005453-4057qib7 4365 1 ( ( -LRB- cord-005453-4057qib7 4365 2 > > NFP cord-005453-4057qib7 4365 3 200 200 CD cord-005453-4057qib7 4365 4 cells cell NNS cord-005453-4057qib7 4365 5 / / SYM cord-005453-4057qib7 4365 6 microl microl NNP cord-005453-4057qib7 4365 7 ) ) -RRB- cord-005453-4057qib7 4365 8 , , . cord-005453-4057qib7 4366 1 NK NK NNP cord-005453-4057qib7 4366 2 ( ( -LRB- cord-005453-4057qib7 4366 3 > > NFP cord-005453-4057qib7 4366 4 100 100 CD cord-005453-4057qib7 4366 5 cells cell NNS cord-005453-4057qib7 4366 6 / / SYM cord-005453-4057qib7 4366 7 microl microl NNP cord-005453-4057qib7 4366 8 ) ) -RRB- cord-005453-4057qib7 4366 9 and and CC cord-005453-4057qib7 4366 10 B b NN cord-005453-4057qib7 4366 11 cells cell NNS cord-005453-4057qib7 4366 12 ( ( -LRB- cord-005453-4057qib7 4367 1 > > XX cord-005453-4057qib7 4367 2 100 100 CD cord-005453-4057qib7 4367 3 cells cell NNS cord-005453-4057qib7 4367 4 / / SYM cord-005453-4057qib7 4367 5 microl microl NNP cord-005453-4057qib7 4367 6 ) ) -RRB- cord-005453-4057qib7 4367 7 . . . cord-005453-4057qib7 4368 1 We -PRON- PRP cord-005453-4057qib7 4368 2 also also RB cord-005453-4057qib7 4368 3 observed observe VBD cord-005453-4057qib7 4368 4 presence presence NN cord-005453-4057qib7 4368 5 of of IN cord-005453-4057qib7 4368 6 B B NNP cord-005453-4057qib7 4368 7 effector effector NN cord-005453-4057qib7 4368 8 and and CC cord-005453-4057qib7 4368 9 B b NN cord-005453-4057qib7 4368 10 memory memory NN cord-005453-4057qib7 4368 11 cells cell NNS cord-005453-4057qib7 4368 12 , , , cord-005453-4057qib7 4368 13 with with IN cord-005453-4057qib7 4368 14 predominance predominance NN cord-005453-4057qib7 4368 15 of of IN cord-005453-4057qib7 4368 16 IgD igd NN cord-005453-4057qib7 4368 17 - - : cord-005453-4057qib7 4368 18 CD27 CD27 NNP cord-005453-4057qib7 4368 19 + + CC cord-005453-4057qib7 4368 20 memory memory NN cord-005453-4057qib7 4368 21 cells cell NNS cord-005453-4057qib7 4368 22 . . . cord-005453-4057qib7 4369 1 Immunoglobulin immunoglobulin NN cord-005453-4057qib7 4369 2 levels level NNS cord-005453-4057qib7 4369 3 were be VBD cord-005453-4057qib7 4369 4 within within IN cord-005453-4057qib7 4369 5 the the DT cord-005453-4057qib7 4369 6 normal normal JJ cord-005453-4057qib7 4369 7 range range NN cord-005453-4057qib7 4369 8 . . . cord-005453-4057qib7 4370 1 In in IN cord-005453-4057qib7 4370 2 this this DT cord-005453-4057qib7 4370 3 group group NN cord-005453-4057qib7 4370 4 , , , cord-005453-4057qib7 4370 5 we -PRON- PRP cord-005453-4057qib7 4370 6 registered register VBD cord-005453-4057qib7 4370 7 vaccination vaccination NN cord-005453-4057qib7 4370 8 in in IN cord-005453-4057qib7 4370 9 13 13 CD cord-005453-4057qib7 4370 10 patients patient NNS cord-005453-4057qib7 4370 11 . . . cord-005453-4057qib7 4371 1 All all DT cord-005453-4057qib7 4371 2 of of IN cord-005453-4057qib7 4371 3 them -PRON- PRP cord-005453-4057qib7 4371 4 were be VBD cord-005453-4057qib7 4371 5 vaccinated vaccinate VBN cord-005453-4057qib7 4371 6 against against IN cord-005453-4057qib7 4371 7 flu flu NN cord-005453-4057qib7 4371 8 , , , cord-005453-4057qib7 4371 9 and and CC cord-005453-4057qib7 4371 10 11 11 CD cord-005453-4057qib7 4371 11 against against IN cord-005453-4057qib7 4371 12 pneumococcus pneumococcus NNP cord-005453-4057qib7 4371 13 and and CC cord-005453-4057qib7 4371 14 HBV HBV NNP cord-005453-4057qib7 4371 15 . . . cord-005453-4057qib7 4372 1 The the DT cord-005453-4057qib7 4372 2 rest rest NN cord-005453-4057qib7 4372 3 of of IN cord-005453-4057qib7 4372 4 vaccines vaccine NNS cord-005453-4057qib7 4372 5 administered administer VBN cord-005453-4057qib7 4372 6 were be VBD cord-005453-4057qib7 4372 7 heterogeneous heterogeneous JJ cord-005453-4057qib7 4372 8 in in IN cord-005453-4057qib7 4372 9 type type NN cord-005453-4057qib7 4372 10 and and CC cord-005453-4057qib7 4372 11 timing timing NN cord-005453-4057qib7 4372 12 . . . cord-005453-4057qib7 4373 1 6 6 CD cord-005453-4057qib7 4373 2 patients patient NNS cord-005453-4057qib7 4373 3 were be VBD cord-005453-4057qib7 4373 4 under under IN cord-005453-4057qib7 4373 5 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4373 6 treatment treatment NN cord-005453-4057qib7 4373 7 at at IN cord-005453-4057qib7 4373 8 the the DT cord-005453-4057qib7 4373 9 time time NN cord-005453-4057qib7 4373 10 of of IN cord-005453-4057qib7 4373 11 vaccination vaccination NN cord-005453-4057qib7 4373 12 and and CC cord-005453-4057qib7 4373 13 were be VBD cord-005453-4057qib7 4373 14 able able JJ cord-005453-4057qib7 4373 15 to to TO cord-005453-4057qib7 4373 16 generate generate VB cord-005453-4057qib7 4373 17 enough enough JJ cord-005453-4057qib7 4373 18 specific specific JJ cord-005453-4057qib7 4373 19 antibodies antibody NNS cord-005453-4057qib7 4373 20 for for IN cord-005453-4057qib7 4373 21 pneumococcus pneumococcus NNP cord-005453-4057qib7 4373 22 . . . cord-005453-4057qib7 4374 1 Conclusions conclusion NNS cord-005453-4057qib7 4374 2 : : : cord-005453-4057qib7 4375 1 Immune immune JJ cord-005453-4057qib7 4375 2 reconstitution reconstitution NN cord-005453-4057qib7 4375 3 was be VBD cord-005453-4057qib7 4375 4 not not RB cord-005453-4057qib7 4375 5 completed complete VBN cord-005453-4057qib7 4375 6 12 12 CD cord-005453-4057qib7 4375 7 months month NNS cord-005453-4057qib7 4375 8 after after IN cord-005453-4057qib7 4375 9 SCT SCT NNP cord-005453-4057qib7 4375 10 , , , cord-005453-4057qib7 4375 11 although although IN cord-005453-4057qib7 4375 12 minimal minimal JJ cord-005453-4057qib7 4375 13 immunological immunological JJ cord-005453-4057qib7 4375 14 reconstitution reconstitution NN cord-005453-4057qib7 4375 15 was be VBD cord-005453-4057qib7 4375 16 observed observe VBN cord-005453-4057qib7 4375 17 TCD4 TCD4 NNP cord-005453-4057qib7 4375 18 + + CC cord-005453-4057qib7 4375 19 and and CC cord-005453-4057qib7 4376 1 no no DT cord-005453-4057qib7 4376 2 - - HYPH cord-005453-4057qib7 4376 3 switching switch VBG cord-005453-4057qib7 4376 4 memory memory NN cord-005453-4057qib7 4376 5 B b NN cord-005453-4057qib7 4376 6 lymphocytes lymphocyte NNS cord-005453-4057qib7 4376 7 were be VBD cord-005453-4057qib7 4376 8 the the DT cord-005453-4057qib7 4376 9 last last JJ cord-005453-4057qib7 4376 10 ones one NNS cord-005453-4057qib7 4376 11 to to TO cord-005453-4057qib7 4376 12 reach reach VB cord-005453-4057qib7 4376 13 minimum minimum JJ cord-005453-4057qib7 4376 14 normal normal JJ cord-005453-4057qib7 4376 15 values value NNS cord-005453-4057qib7 4376 16 according accord VBG cord-005453-4057qib7 4376 17 to to IN cord-005453-4057qib7 4376 18 patient patient JJ cord-005453-4057qib7 4376 19 age age NN cord-005453-4057qib7 4376 20 . . . cord-005453-4057qib7 4377 1 Some some DT cord-005453-4057qib7 4377 2 patients patient NNS cord-005453-4057qib7 4377 3 maintain maintain VBP cord-005453-4057qib7 4377 4 serological serological JJ cord-005453-4057qib7 4377 5 protection protection NN cord-005453-4057qib7 4377 6 after after IN cord-005453-4057qib7 4377 7 allogenic allogenic JJ cord-005453-4057qib7 4377 8 SCT SCT NNP cord-005453-4057qib7 4377 9 . . . cord-005453-4057qib7 4378 1 Immunoglobulin immunoglobulin NN cord-005453-4057qib7 4378 2 levels level NNS cord-005453-4057qib7 4378 3 were be VBD cord-005453-4057qib7 4378 4 normal normal JJ cord-005453-4057qib7 4378 5 , , , cord-005453-4057qib7 4378 6 suggesting suggest VBG cord-005453-4057qib7 4378 7 no no DT cord-005453-4057qib7 4378 8 need need NN cord-005453-4057qib7 4378 9 for for IN cord-005453-4057qib7 4378 10 immunoglobulin immunoglobulin NN cord-005453-4057qib7 4378 11 administration administration NN cord-005453-4057qib7 4378 12 to to TO cord-005453-4057qib7 4378 13 prevent prevent VB cord-005453-4057qib7 4378 14 infections infection NNS cord-005453-4057qib7 4378 15 . . . cord-005453-4057qib7 4379 1 Flu flu NN cord-005453-4057qib7 4379 2 , , , cord-005453-4057qib7 4379 3 pneumococcus pneumococcus NN cord-005453-4057qib7 4379 4 and and CC cord-005453-4057qib7 4379 5 HBV HBV NNP cord-005453-4057qib7 4379 6 vaccines vaccine NNS cord-005453-4057qib7 4379 7 were be VBD cord-005453-4057qib7 4379 8 the the DT cord-005453-4057qib7 4379 9 most most RBS cord-005453-4057qib7 4379 10 frequently frequently RB cord-005453-4057qib7 4379 11 administered administer VBN cord-005453-4057qib7 4379 12 . . . cord-005453-4057qib7 4380 1 Pneumococcus Pneumococcus NNP cord-005453-4057qib7 4380 2 vaccination vaccination NN cord-005453-4057qib7 4380 3 generated generate VBD cord-005453-4057qib7 4380 4 a a DT cord-005453-4057qib7 4380 5 much much RB cord-005453-4057qib7 4380 6 larger large JJR cord-005453-4057qib7 4380 7 serological serological JJ cord-005453-4057qib7 4380 8 response response NN cord-005453-4057qib7 4380 9 than than IN cord-005453-4057qib7 4380 10 HBV HBV NNP cord-005453-4057qib7 4380 11 . . . cord-005453-4057qib7 4381 1 This this DT cord-005453-4057qib7 4381 2 seroconversion seroconversion NN cord-005453-4057qib7 4381 3 occurred occur VBD cord-005453-4057qib7 4381 4 in in IN cord-005453-4057qib7 4381 5 patients patient NNS cord-005453-4057qib7 4381 6 under under IN cord-005453-4057qib7 4381 7 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4381 8 treatment treatment NN cord-005453-4057qib7 4381 9 . . . cord-005453-4057qib7 4382 1 The the DT cord-005453-4057qib7 4382 2 analysis analysis NN cord-005453-4057qib7 4382 3 of of IN cord-005453-4057qib7 4382 4 lymphocyte lymphocyte NN cord-005453-4057qib7 4382 5 T T NNP cord-005453-4057qib7 4382 6 , , , cord-005453-4057qib7 4382 7 NK NK NNP cord-005453-4057qib7 4382 8 , , , cord-005453-4057qib7 4382 9 B B NNP cord-005453-4057qib7 4382 10 total total NN cord-005453-4057qib7 4382 11 and and CC cord-005453-4057qib7 4382 12 B b VB cord-005453-4057qib7 4382 13 functional functional JJ cord-005453-4057qib7 4382 14 subsets subset NNS cord-005453-4057qib7 4382 15 could could MD cord-005453-4057qib7 4382 16 be be VB cord-005453-4057qib7 4382 17 useful useful JJ cord-005453-4057qib7 4382 18 when when WRB cord-005453-4057qib7 4382 19 programming program VBG cord-005453-4057qib7 4382 20 an an DT cord-005453-4057qib7 4382 21 early early JJ cord-005453-4057qib7 4382 22 vaccination vaccination NN cord-005453-4057qib7 4382 23 schedule schedule NN cord-005453-4057qib7 4382 24 after after IN cord-005453-4057qib7 4382 25 SCT SCT NNP cord-005453-4057qib7 4382 26 . . . cord-005453-4057qib7 4383 1 Completion completion NN cord-005453-4057qib7 4383 2 of of IN cord-005453-4057qib7 4383 3 the the DT cord-005453-4057qib7 4383 4 vaccination vaccination NN cord-005453-4057qib7 4383 5 schedule schedule NN cord-005453-4057qib7 4383 6 was be VBD cord-005453-4057qib7 4383 7 heterogeneous heterogeneous JJ cord-005453-4057qib7 4383 8 despite despite IN cord-005453-4057qib7 4383 9 giving give VBG cord-005453-4057qib7 4383 10 specific specific JJ cord-005453-4057qib7 4383 11 indications indication NNS cord-005453-4057qib7 4383 12 . . . cord-005453-4057qib7 4384 1 Therefore therefore RB cord-005453-4057qib7 4384 2 a a DT cord-005453-4057qib7 4384 3 more more RBR cord-005453-4057qib7 4384 4 rigorous rigorous JJ cord-005453-4057qib7 4384 5 supervision supervision NN cord-005453-4057qib7 4384 6 of of IN cord-005453-4057qib7 4384 7 the the DT cord-005453-4057qib7 4384 8 process process NN cord-005453-4057qib7 4384 9 may may MD cord-005453-4057qib7 4384 10 be be VB cord-005453-4057qib7 4384 11 required require VBN cord-005453-4057qib7 4384 12 . . . cord-005453-4057qib7 4385 1 Background background NN cord-005453-4057qib7 4385 2 : : : cord-005453-4057qib7 4386 1 The the DT cord-005453-4057qib7 4386 2 significant significant JJ cord-005453-4057qib7 4386 3 advances advance NNS cord-005453-4057qib7 4386 4 that that WDT cord-005453-4057qib7 4386 5 have have VBP cord-005453-4057qib7 4386 6 been be VBN cord-005453-4057qib7 4386 7 achieved achieve VBN cord-005453-4057qib7 4386 8 in in IN cord-005453-4057qib7 4386 9 the the DT cord-005453-4057qib7 4386 10 allogeneic allogeneic NN cord-005453-4057qib7 4386 11 transplantation transplantation NN cord-005453-4057qib7 4386 12 ( ( -LRB- cord-005453-4057qib7 4386 13 alloHCT alloHCT NNP cord-005453-4057qib7 4386 14 ) ) -RRB- cord-005453-4057qib7 4386 15 field field NN cord-005453-4057qib7 4386 16 , , , cord-005453-4057qib7 4386 17 have have VBP cord-005453-4057qib7 4386 18 resulted result VBN cord-005453-4057qib7 4386 19 in in IN cord-005453-4057qib7 4386 20 better well JJR cord-005453-4057qib7 4386 21 post post JJ cord-005453-4057qib7 4386 22 - - JJ cord-005453-4057qib7 4386 23 transplant transplant JJ cord-005453-4057qib7 4386 24 outcome outcome NN cord-005453-4057qib7 4386 25 and and CC cord-005453-4057qib7 4386 26 therefore therefore RB cord-005453-4057qib7 4386 27 complications complication NNS cord-005453-4057qib7 4386 28 other other JJ cord-005453-4057qib7 4386 29 than than IN cord-005453-4057qib7 4386 30 the the DT cord-005453-4057qib7 4386 31 Graft Graft NNP cord-005453-4057qib7 4386 32 vs. vs. IN cord-005453-4057qib7 4386 33 Host host NN cord-005453-4057qib7 4386 34 disease disease NN cord-005453-4057qib7 4386 35 ( ( -LRB- cord-005453-4057qib7 4386 36 GvHD GvHD NNP cord-005453-4057qib7 4386 37 ) ) -RRB- cord-005453-4057qib7 4386 38 or or CC cord-005453-4057qib7 4386 39 disease disease NN cord-005453-4057qib7 4386 40 recurrence recurrence NN cord-005453-4057qib7 4386 41 become become VBP cord-005453-4057qib7 4386 42 increasingly increasingly RB cord-005453-4057qib7 4386 43 important important JJ cord-005453-4057qib7 4386 44 . . . cord-005453-4057qib7 4387 1 The the DT cord-005453-4057qib7 4387 2 post post JJ cord-005453-4057qib7 4387 3 transplant transplant NN cord-005453-4057qib7 4387 4 metabolic metabolic JJ cord-005453-4057qib7 4387 5 syndrome syndrome NN cord-005453-4057qib7 4387 6 ( ( -LRB- cord-005453-4057qib7 4387 7 PT PT NNP cord-005453-4057qib7 4387 8 - - HYPH cord-005453-4057qib7 4387 9 MS MS NNP cord-005453-4057qib7 4387 10 ) ) -RRB- cord-005453-4057qib7 4387 11 , , , cord-005453-4057qib7 4387 12 which which WDT cord-005453-4057qib7 4387 13 caused cause VBN cord-005453-4057qib7 4387 14 by by IN cord-005453-4057qib7 4387 15 several several JJ cord-005453-4057qib7 4387 16 factors factor NNS cord-005453-4057qib7 4387 17 ( ( -LRB- cord-005453-4057qib7 4387 18 i.e. i.e. FW cord-005453-4057qib7 4387 19 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4387 20 agents agent NNS cord-005453-4057qib7 4387 21 , , , cord-005453-4057qib7 4387 22 chemo chemo NN cord-005453-4057qib7 4387 23 - - HYPH cord-005453-4057qib7 4387 24 radiotherapy radiotherapy NN cord-005453-4057qib7 4387 25 , , , cord-005453-4057qib7 4387 26 anti anti JJ cord-005453-4057qib7 4387 27 - - JJ cord-005453-4057qib7 4387 28 viral viral JJ cord-005453-4057qib7 4387 29 , , , cord-005453-4057qib7 4387 30 and and CC cord-005453-4057qib7 4387 31 biologic biologic JJ cord-005453-4057qib7 4387 32 therapies therapy NNS cord-005453-4057qib7 4387 33 ) ) -RRB- cord-005453-4057qib7 4387 34 is be VBZ cord-005453-4057qib7 4387 35 a a DT cord-005453-4057qib7 4387 36 well well RB cord-005453-4057qib7 4387 37 known know VBN cord-005453-4057qib7 4387 38 post post NN cord-005453-4057qib7 4387 39 transplant transplant NN cord-005453-4057qib7 4387 40 complication complication NN cord-005453-4057qib7 4387 41 in in IN cord-005453-4057qib7 4387 42 pediatric pediatric JJ cord-005453-4057qib7 4387 43 allografted allografte VBN cord-005453-4057qib7 4387 44 long long JJ cord-005453-4057qib7 4387 45 - - HYPH cord-005453-4057qib7 4387 46 term term NN cord-005453-4057qib7 4387 47 survivors survivor NNS cord-005453-4057qib7 4387 48 however however RB cord-005453-4057qib7 4387 49 , , , cord-005453-4057qib7 4387 50 only only RB cord-005453-4057qib7 4387 51 few few JJ cord-005453-4057qib7 4387 52 studies study NNS cord-005453-4057qib7 4387 53 have have VBP cord-005453-4057qib7 4387 54 evaluated evaluate VBN cord-005453-4057qib7 4387 55 the the DT cord-005453-4057qib7 4387 56 prevalence prevalence NN cord-005453-4057qib7 4387 57 of of IN cord-005453-4057qib7 4387 58 the the DT cord-005453-4057qib7 4387 59 PT PT NNP cord-005453-4057qib7 4387 60 - - HYPH cord-005453-4057qib7 4387 61 MS MS NNP cord-005453-4057qib7 4387 62 in in IN cord-005453-4057qib7 4387 63 adults adult NNS cord-005453-4057qib7 4387 64 . . . cord-005453-4057qib7 4388 1 In in IN cord-005453-4057qib7 4388 2 this this DT cord-005453-4057qib7 4388 3 retrospective retrospective JJ cord-005453-4057qib7 4388 4 study study NN cord-005453-4057qib7 4388 5 , , , cord-005453-4057qib7 4388 6 we -PRON- PRP cord-005453-4057qib7 4388 7 sought seek VBD cord-005453-4057qib7 4388 8 to to TO cord-005453-4057qib7 4388 9 evaluate evaluate VB cord-005453-4057qib7 4388 10 the the DT cord-005453-4057qib7 4388 11 incidence incidence NN cord-005453-4057qib7 4388 12 , , , cord-005453-4057qib7 4388 13 the the DT cord-005453-4057qib7 4388 14 risk risk NN cord-005453-4057qib7 4388 15 factors factor NNS cord-005453-4057qib7 4388 16 and and CC cord-005453-4057qib7 4388 17 the the DT cord-005453-4057qib7 4388 18 impact impact NN cord-005453-4057qib7 4388 19 of of IN cord-005453-4057qib7 4388 20 the the DT cord-005453-4057qib7 4388 21 PT PT NNP cord-005453-4057qib7 4388 22 - - HYPH cord-005453-4057qib7 4388 23 MS MS NNP cord-005453-4057qib7 4388 24 on on IN cord-005453-4057qib7 4388 25 the the DT cord-005453-4057qib7 4388 26 alloSCT alloSCT NNP cord-005453-4057qib7 4388 27 outcome outcome NN cord-005453-4057qib7 4388 28 . . . cord-005453-4057qib7 4389 1 Methods method NNS cord-005453-4057qib7 4389 2 : : : cord-005453-4057qib7 4389 3 Since since IN cord-005453-4057qib7 4389 4 2011 2011 CD cord-005453-4057qib7 4389 5 , , , cord-005453-4057qib7 4389 6 42 42 CD cord-005453-4057qib7 4389 7 patients patient NNS cord-005453-4057qib7 4389 8 ( ( -LRB- cord-005453-4057qib7 4389 9 25 25 CD cord-005453-4057qib7 4389 10 males male NNS cord-005453-4057qib7 4389 11 and and CC cord-005453-4057qib7 4389 12 17 17 CD cord-005453-4057qib7 4389 13 females female NNS cord-005453-4057qib7 4389 14 ) ) -RRB- cord-005453-4057qib7 4389 15 with with IN cord-005453-4057qib7 4389 16 adequate adequate JJ cord-005453-4057qib7 4389 17 clinical clinical JJ cord-005453-4057qib7 4389 18 and and CC cord-005453-4057qib7 4389 19 laboratory laboratory NN cord-005453-4057qib7 4389 20 data datum NNS cord-005453-4057qib7 4389 21 and and CC cord-005453-4057qib7 4389 22 a a DT cord-005453-4057qib7 4389 23 minimum minimum JJ cord-005453-4057qib7 4389 24 follow follow NN cord-005453-4057qib7 4389 25 - - HYPH cord-005453-4057qib7 4389 26 up up NN cord-005453-4057qib7 4389 27 of of IN cord-005453-4057qib7 4389 28 6 6 CD cord-005453-4057qib7 4389 29 months month NNS cord-005453-4057qib7 4389 30 were be VBD cord-005453-4057qib7 4389 31 included include VBN cord-005453-4057qib7 4389 32 in in IN cord-005453-4057qib7 4389 33 the the DT cord-005453-4057qib7 4389 34 study study NN cord-005453-4057qib7 4389 35 . . . cord-005453-4057qib7 4390 1 Their -PRON- PRP$ cord-005453-4057qib7 4390 2 median median JJ cord-005453-4057qib7 4390 3 age age NN cord-005453-4057qib7 4390 4 was be VBD cord-005453-4057qib7 4390 5 35.5 35.5 CD cord-005453-4057qib7 4390 6 ( ( -LRB- cord-005453-4057qib7 4390 7 17 17 CD cord-005453-4057qib7 4390 8 - - SYM cord-005453-4057qib7 4390 9 62 62 CD cord-005453-4057qib7 4390 10 ) ) -RRB- cord-005453-4057qib7 4390 11 years year NNS cord-005453-4057qib7 4390 12 and and CC cord-005453-4057qib7 4390 13 after after IN cord-005453-4057qib7 4390 14 a a DT cord-005453-4057qib7 4390 15 myeloablative myeloablative NNP cord-005453-4057qib7 4390 16 ( ( -LRB- cord-005453-4057qib7 4390 17 n=28 n=28 NN cord-005453-4057qib7 4390 18 ) ) -RRB- cord-005453-4057qib7 4390 19 or or CC cord-005453-4057qib7 4390 20 a a DT cord-005453-4057qib7 4390 21 reduced reduce VBN cord-005453-4057qib7 4390 22 intensity intensity NN cord-005453-4057qib7 4391 1 ( ( -LRB- cord-005453-4057qib7 4391 2 n=14 n=14 NNP cord-005453-4057qib7 4391 3 ) ) -RRB- cord-005453-4057qib7 4391 4 regimen regimen NN cord-005453-4057qib7 4391 5 they -PRON- PRP cord-005453-4057qib7 4391 6 received receive VBD cord-005453-4057qib7 4391 7 either either CC cord-005453-4057qib7 4391 8 mobilized mobilize VBD cord-005453-4057qib7 4391 9 peripheral peripheral JJ cord-005453-4057qib7 4391 10 blood blood NN cord-005453-4057qib7 4391 11 stem stem NN cord-005453-4057qib7 4391 12 cells cell NNS cord-005453-4057qib7 4391 13 ( ( -LRB- cord-005453-4057qib7 4391 14 n=34 n=34 NNP cord-005453-4057qib7 4391 15 ) ) -RRB- cord-005453-4057qib7 4391 16 or or CC cord-005453-4057qib7 4391 17 marrow marrow NN cord-005453-4057qib7 4391 18 graft graft NN cord-005453-4057qib7 4391 19 ( ( -LRB- cord-005453-4057qib7 4391 20 n=8 n=8 NN cord-005453-4057qib7 4391 21 ) ) -RRB- cord-005453-4057qib7 4391 22 , , , cord-005453-4057qib7 4391 23 originated originate VBD cord-005453-4057qib7 4391 24 from from IN cord-005453-4057qib7 4391 25 full full RB cord-005453-4057qib7 4391 26 - - HYPH cord-005453-4057qib7 4391 27 matched match VBN cord-005453-4057qib7 4391 28 siblings sibling NNS cord-005453-4057qib7 4391 29 ( ( -LRB- cord-005453-4057qib7 4391 30 n=35 n=35 NNP cord-005453-4057qib7 4391 31 ) ) -RRB- cord-005453-4057qib7 4391 32 or or CC cord-005453-4057qib7 4391 33 haploidentical haploidentical JJ cord-005453-4057qib7 4391 34 donors donor NNS cord-005453-4057qib7 4391 35 ( ( -LRB- cord-005453-4057qib7 4391 36 n=7 n=7 NNS cord-005453-4057qib7 4391 37 ) ) -RRB- cord-005453-4057qib7 4391 38 . . . cord-005453-4057qib7 4392 1 Calcineurin Calcineurin NNP cord-005453-4057qib7 4392 2 inhibitors inhibitor NNS cord-005453-4057qib7 4392 3 plus plus CC cord-005453-4057qib7 4392 4 either either CC cord-005453-4057qib7 4392 5 short short JJ cord-005453-4057qib7 4392 6 - - HYPH cord-005453-4057qib7 4392 7 term term NN cord-005453-4057qib7 4392 8 Methotrexate Methotrexate NNP cord-005453-4057qib7 4392 9 or or CC cord-005453-4057qib7 4392 10 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 4392 11 Mofetil Mofetil NNP cord-005453-4057qib7 4392 12 were be VBD cord-005453-4057qib7 4392 13 given give VBN cord-005453-4057qib7 4392 14 as as IN cord-005453-4057qib7 4392 15 GvHD GvHD NNP cord-005453-4057qib7 4392 16 prophylaxis prophylaxis NN cord-005453-4057qib7 4392 17 . . . cord-005453-4057qib7 4393 1 The the DT cord-005453-4057qib7 4393 2 diagnosis diagnosis NN cord-005453-4057qib7 4393 3 of of IN cord-005453-4057qib7 4393 4 PT PT NNP cord-005453-4057qib7 4393 5 - - HYPH cord-005453-4057qib7 4393 6 MS MS NNP cord-005453-4057qib7 4393 7 was be VBD cord-005453-4057qib7 4393 8 based base VBN cord-005453-4057qib7 4393 9 on on IN cord-005453-4057qib7 4393 10 the the DT cord-005453-4057qib7 4393 11 NCEP NCEP NNP cord-005453-4057qib7 4393 12 - - HYPH cord-005453-4057qib7 4393 13 ATPIII ATPIII NNP cord-005453-4057qib7 4393 14 criteria criterion NNS cord-005453-4057qib7 4393 15 ; ; : cord-005453-4057qib7 4393 16 for for IN cord-005453-4057qib7 4393 17 patients patient NNS cord-005453-4057qib7 4393 18 with with IN cord-005453-4057qib7 4393 19 unknown unknown JJ cord-005453-4057qib7 4393 20 data datum NNS cord-005453-4057qib7 4393 21 for for IN cord-005453-4057qib7 4393 22 abdominal abdominal JJ cord-005453-4057qib7 4393 23 circumference circumference NN cord-005453-4057qib7 4393 24 the the DT cord-005453-4057qib7 4393 25 body body NN cord-005453-4057qib7 4393 26 mass mass NN cord-005453-4057qib7 4393 27 index index NN cord-005453-4057qib7 4393 28 ( ( -LRB- cord-005453-4057qib7 4393 29 BMI BMI NNP cord-005453-4057qib7 4393 30 ) ) -RRB- cord-005453-4057qib7 4393 31 ≥25kg ≥25kg NNP cord-005453-4057qib7 4393 32 / / SYM cord-005453-4057qib7 4393 33 m m NNP cord-005453-4057qib7 4393 34 2 2 CD cord-005453-4057qib7 4393 35 was be VBD cord-005453-4057qib7 4393 36 consider consider JJ cord-005453-4057qib7 4393 37 as as IN cord-005453-4057qib7 4393 38 a a DT cord-005453-4057qib7 4393 39 criterion criterion NN cord-005453-4057qib7 4393 40 for for IN cord-005453-4057qib7 4393 41 PT PT NNP cord-005453-4057qib7 4393 42 - - HYPH cord-005453-4057qib7 4393 43 MS MS NNP cord-005453-4057qib7 4393 44 diagnosis diagnosis NN cord-005453-4057qib7 4393 45 . . . cord-005453-4057qib7 4394 1 The the DT cord-005453-4057qib7 4394 2 independent independent JJ cord-005453-4057qib7 4394 3 T t NN cord-005453-4057qib7 4394 4 - - HYPH cord-005453-4057qib7 4394 5 test test NN cord-005453-4057qib7 4394 6 , , , cord-005453-4057qib7 4394 7 logistic logistic JJ cord-005453-4057qib7 4394 8 regression regression NN cord-005453-4057qib7 4394 9 analysis analysis NN cord-005453-4057qib7 4394 10 and and CC cord-005453-4057qib7 4394 11 logrank logrank NN cord-005453-4057qib7 4394 12 tests test NNS cord-005453-4057qib7 4394 13 were be VBD cord-005453-4057qib7 4394 14 used use VBN cord-005453-4057qib7 4394 15 for for IN cord-005453-4057qib7 4394 16 the the DT cord-005453-4057qib7 4394 17 statistical statistical JJ cord-005453-4057qib7 4394 18 analysis analysis NN cord-005453-4057qib7 4394 19 . . . cord-005453-4057qib7 4395 1 Results result NNS cord-005453-4057qib7 4395 2 : : : cord-005453-4057qib7 4396 1 Twenty twenty CD cord-005453-4057qib7 4396 2 ( ( -LRB- cord-005453-4057qib7 4396 3 47.6 47.6 CD cord-005453-4057qib7 4396 4 % % NN cord-005453-4057qib7 4396 5 ) ) -RRB- cord-005453-4057qib7 4396 6 patients patient NNS cord-005453-4057qib7 4396 7 ( ( -LRB- cord-005453-4057qib7 4396 8 12 12 CD cord-005453-4057qib7 4396 9 males male NNS cord-005453-4057qib7 4396 10 , , , cord-005453-4057qib7 4396 11 8 8 CD cord-005453-4057qib7 4396 12 females female NNS cord-005453-4057qib7 4396 13 ) ) -RRB- cord-005453-4057qib7 4396 14 assessed assess VBN cord-005453-4057qib7 4396 15 to to TO cord-005453-4057qib7 4396 16 have have VB cord-005453-4057qib7 4396 17 PT PT NNP cord-005453-4057qib7 4396 18 - - HYPH cord-005453-4057qib7 4396 19 MS MS NNP cord-005453-4057qib7 4396 20 within within IN cord-005453-4057qib7 4396 21 the the DT cord-005453-4057qib7 4396 22 first first JJ cord-005453-4057qib7 4396 23 6 6 CD cord-005453-4057qib7 4396 24 months month NNS cord-005453-4057qib7 4396 25 following follow VBG cord-005453-4057qib7 4396 26 the the DT cord-005453-4057qib7 4396 27 allograft allograft NN cord-005453-4057qib7 4396 28 . . . cord-005453-4057qib7 4397 1 Seventeen seventeen CD cord-005453-4057qib7 4397 2 diagnosed diagnose VBN cord-005453-4057qib7 4397 3 after after IN cord-005453-4057qib7 4397 4 the the DT cord-005453-4057qib7 4397 5 1 1 CD cord-005453-4057qib7 4397 6 st st NNP cord-005453-4057qib7 4397 7 trimester trimester NNP cord-005453-4057qib7 4397 8 post post NNP cord-005453-4057qib7 4398 1 alloSCT alloSCT NNP cord-005453-4057qib7 4398 2 and and CC cord-005453-4057qib7 4398 3 additional additional JJ cord-005453-4057qib7 4398 4 3 3 CD cord-005453-4057qib7 4398 5 patients patient NNS cord-005453-4057qib7 4398 6 after after IN cord-005453-4057qib7 4398 7 2 2 CD cord-005453-4057qib7 4398 8 nd nd NNP cord-005453-4057qib7 4398 9 trimester trimester NN cord-005453-4057qib7 4398 10 . . . cord-005453-4057qib7 4399 1 Sixteen sixteen CD cord-005453-4057qib7 4399 2 out out IN cord-005453-4057qib7 4399 3 of of IN cord-005453-4057qib7 4399 4 20 20 CD cord-005453-4057qib7 4399 5 patients patient NNS cord-005453-4057qib7 4399 6 had have VBD cord-005453-4057qib7 4399 7 elevated elevate VBN cord-005453-4057qib7 4399 8 glucose glucose NN cord-005453-4057qib7 4399 9 and and CC cord-005453-4057qib7 4399 10 BMI>25kg BMI>25kg NNP cord-005453-4057qib7 4399 11 / / SYM cord-005453-4057qib7 4399 12 m m NN cord-005453-4057qib7 4399 13 2 2 CD cord-005453-4057qib7 4399 14 , , , cord-005453-4057qib7 4399 15 13/20 13/20 CD cord-005453-4057qib7 4399 16 elevated elevate VBN cord-005453-4057qib7 4399 17 triglycerides triglyceride NNS cord-005453-4057qib7 4399 18 levels level NNS cord-005453-4057qib7 4399 19 , , , cord-005453-4057qib7 4399 20 12/20 12/20 CD cord-005453-4057qib7 4399 21 low low JJ cord-005453-4057qib7 4399 22 HDL HDL NNP cord-005453-4057qib7 4399 23 levels level NNS cord-005453-4057qib7 4399 24 and and CC cord-005453-4057qib7 4399 25 10/20 10/20 CD cord-005453-4057qib7 4399 26 hypertension hypertension NN cord-005453-4057qib7 4399 27 . . . cord-005453-4057qib7 4400 1 Four four CD cord-005453-4057qib7 4400 2 ( ( -LRB- cord-005453-4057qib7 4400 3 20 20 CD cord-005453-4057qib7 4400 4 % % NN cord-005453-4057qib7 4400 5 ) ) -RRB- cord-005453-4057qib7 4400 6 had have VBD cord-005453-4057qib7 4400 7 already already RB cord-005453-4057qib7 4400 8 known know VBN cord-005453-4057qib7 4400 9 history history NN cord-005453-4057qib7 4400 10 of of IN cord-005453-4057qib7 4400 11 MS MS NNP cord-005453-4057qib7 4400 12 before before IN cord-005453-4057qib7 4400 13 alloSCT alloSCT NNP cord-005453-4057qib7 4400 14 ( ( -LRB- cord-005453-4057qib7 4400 15 for for IN cord-005453-4057qib7 4400 16 10 10 CD cord-005453-4057qib7 4400 17 patients patient NNS cord-005453-4057qib7 4401 1 no no DT cord-005453-4057qib7 4401 2 data datum NNS cord-005453-4057qib7 4401 3 were be VBD cord-005453-4057qib7 4401 4 available available JJ cord-005453-4057qib7 4401 5 for for IN cord-005453-4057qib7 4401 6 MS MS NNP cord-005453-4057qib7 4401 7 diagnosis diagnosis NN cord-005453-4057qib7 4401 8 before before IN cord-005453-4057qib7 4401 9 alloSCT alloSCT NNP cord-005453-4057qib7 4401 10 ) ) -RRB- cord-005453-4057qib7 4401 11 . . . cord-005453-4057qib7 4402 1 Interestingly interestingly RB cord-005453-4057qib7 4402 2 , , , cord-005453-4057qib7 4402 3 for for IN cord-005453-4057qib7 4402 4 7/20(35 7/20(35 CD cord-005453-4057qib7 4402 5 % % NN cord-005453-4057qib7 4402 6 ) ) -RRB- cord-005453-4057qib7 4402 7 patients patient NNS cord-005453-4057qib7 4402 8 who who WP cord-005453-4057qib7 4402 9 had have VBD cord-005453-4057qib7 4402 10 diagnosed diagnose VBN cord-005453-4057qib7 4402 11 with with IN cord-005453-4057qib7 4402 12 PT PT NNP cord-005453-4057qib7 4402 13 - - HYPH cord-005453-4057qib7 4402 14 MS MS NNP cord-005453-4057qib7 4402 15 either either CC cord-005453-4057qib7 4402 16 in in IN cord-005453-4057qib7 4402 17 the the DT cord-005453-4057qib7 4402 18 1 1 CD cord-005453-4057qib7 4402 19 st st NNP cord-005453-4057qib7 4402 20 or or CC cord-005453-4057qib7 4402 21 in in IN cord-005453-4057qib7 4402 22 the the DT cord-005453-4057qib7 4402 23 2 2 CD cord-005453-4057qib7 4402 24 nd nd NNP cord-005453-4057qib7 4402 25 trimester trimester NNP cord-005453-4057qib7 4402 26 the the DT cord-005453-4057qib7 4402 27 syndrome syndrome NN cord-005453-4057qib7 4402 28 was be VBD cord-005453-4057qib7 4402 29 reversible reversible JJ cord-005453-4057qib7 4402 30 and and CC cord-005453-4057qib7 4402 31 did do VBD cord-005453-4057qib7 4402 32 not not RB cord-005453-4057qib7 4402 33 fulfill fulfill VB cord-005453-4057qib7 4402 34 the the DT cord-005453-4057qib7 4402 35 criteria criterion NNS cord-005453-4057qib7 4402 36 for for IN cord-005453-4057qib7 4402 37 PT PT NNP cord-005453-4057qib7 4402 38 - - HYPH cord-005453-4057qib7 4402 39 MS MS NNP cord-005453-4057qib7 4402 40 beyond beyond IN cord-005453-4057qib7 4402 41 6 6 CD cord-005453-4057qib7 4402 42 months month NNS cord-005453-4057qib7 4402 43 post post NN cord-005453-4057qib7 4402 44 alloSCT alloSCT NNP cord-005453-4057qib7 4402 45 . . . cord-005453-4057qib7 4403 1 Patients patient NNS cord-005453-4057qib7 4403 2 ' ' POS cord-005453-4057qib7 4403 3 gender gender NN cord-005453-4057qib7 4403 4 , , , cord-005453-4057qib7 4403 5 age age NN cord-005453-4057qib7 4403 6 , , , cord-005453-4057qib7 4403 7 BMI BMI NNP cord-005453-4057qib7 4403 8 , , , cord-005453-4057qib7 4403 9 the the DT cord-005453-4057qib7 4403 10 type type NN cord-005453-4057qib7 4403 11 of of IN cord-005453-4057qib7 4403 12 conditioning conditioning NN cord-005453-4057qib7 4403 13 regimen regimen NN cord-005453-4057qib7 4403 14 and and CC cord-005453-4057qib7 4403 15 GvHD gvhd NN cord-005453-4057qib7 4403 16 co co NN cord-005453-4057qib7 4403 17 - - NN cord-005453-4057qib7 4403 18 existence existence NN cord-005453-4057qib7 4403 19 evaluated evaluate VBN cord-005453-4057qib7 4403 20 as as IN cord-005453-4057qib7 4403 21 potential potential JJ cord-005453-4057qib7 4403 22 predisposing predispose VBG cord-005453-4057qib7 4403 23 factors factor NNS cord-005453-4057qib7 4403 24 for for IN cord-005453-4057qib7 4403 25 PT PT NNP cord-005453-4057qib7 4403 26 - - HYPH cord-005453-4057qib7 4403 27 MS MS NNP cord-005453-4057qib7 4403 28 diagnosis diagnosis NN cord-005453-4057qib7 4403 29 . . . cord-005453-4057qib7 4404 1 In in IN cord-005453-4057qib7 4404 2 univariate univariate JJ cord-005453-4057qib7 4404 3 and and CC cord-005453-4057qib7 4404 4 multivariate multivariate JJ cord-005453-4057qib7 4404 5 analysis analysis NN cord-005453-4057qib7 4404 6 only only RB cord-005453-4057qib7 4404 7 the the DT cord-005453-4057qib7 4404 8 : : : cord-005453-4057qib7 4404 9 BMI>25kg BMI>25kg NNP cord-005453-4057qib7 4404 10 / / SYM cord-005453-4057qib7 4404 11 m m NN cord-005453-4057qib7 4404 12 2 2 CD cord-005453-4057qib7 4404 13 and and CC cord-005453-4057qib7 4404 14 age>35 age>35 CD cord-005453-4057qib7 4404 15 years year NNS cord-005453-4057qib7 4404 16 were be VBD cord-005453-4057qib7 4404 17 detected detect VBN cord-005453-4057qib7 4404 18 as as IN cord-005453-4057qib7 4404 19 significant significant JJ cord-005453-4057qib7 4404 20 risk risk NN cord-005453-4057qib7 4404 21 factors factor NNS cord-005453-4057qib7 4404 22 ( ( -LRB- cord-005453-4057qib7 4404 23 p p NN cord-005453-4057qib7 4404 24 < < XX cord-005453-4057qib7 4404 25 0.03 0.03 CD cord-005453-4057qib7 4404 26 ) ) -RRB- cord-005453-4057qib7 4404 27 . . . cord-005453-4057qib7 4405 1 The the DT cord-005453-4057qib7 4405 2 PT PT NNP cord-005453-4057qib7 4405 3 - - HYPH cord-005453-4057qib7 4405 4 MS MS NNP cord-005453-4057qib7 4405 5 did do VBD cord-005453-4057qib7 4405 6 not not RB cord-005453-4057qib7 4405 7 affected affect VBN cord-005453-4057qib7 4405 8 negatively negatively RB cord-005453-4057qib7 4405 9 the the DT cord-005453-4057qib7 4405 10 survival survival NN cord-005453-4057qib7 4405 11 or or CC cord-005453-4057qib7 4405 12 the the DT cord-005453-4057qib7 4405 13 NRM NRM NNP cord-005453-4057qib7 4406 1 incidence incidence NN cord-005453-4057qib7 4406 2 post post NN cord-005453-4057qib7 4406 3 alloSCT alloSCT NNP cord-005453-4057qib7 4406 4 Conclusions conclusion NNS cord-005453-4057qib7 4406 5 : : : cord-005453-4057qib7 4407 1 In in IN cord-005453-4057qib7 4407 2 our -PRON- PRP$ cord-005453-4057qib7 4407 3 study study NN cord-005453-4057qib7 4407 4 , , , cord-005453-4057qib7 4407 5 in in IN cord-005453-4057qib7 4407 6 agreement agreement NN cord-005453-4057qib7 4407 7 with with IN cord-005453-4057qib7 4407 8 other other JJ cord-005453-4057qib7 4407 9 publications publication NNS cord-005453-4057qib7 4407 10 , , , cord-005453-4057qib7 4407 11 we -PRON- PRP cord-005453-4057qib7 4407 12 demonstrated demonstrate VBD cord-005453-4057qib7 4407 13 that that IN cord-005453-4057qib7 4407 14 the the DT cord-005453-4057qib7 4407 15 PT PT NNP cord-005453-4057qib7 4407 16 - - HYPH cord-005453-4057qib7 4407 17 MS MS NNP cord-005453-4057qib7 4407 18 is be VBZ cord-005453-4057qib7 4407 19 not not RB cord-005453-4057qib7 4407 20 an an DT cord-005453-4057qib7 4407 21 uncommon uncommon JJ cord-005453-4057qib7 4407 22 complication complication NN cord-005453-4057qib7 4407 23 post post NN cord-005453-4057qib7 4407 24 in in IN cord-005453-4057qib7 4407 25 the the DT cord-005453-4057qib7 4407 26 early early JJ cord-005453-4057qib7 4407 27 post post JJ cord-005453-4057qib7 4407 28 transplant transplant NN cord-005453-4057qib7 4407 29 period period NN cord-005453-4057qib7 4407 30 however however RB cord-005453-4057qib7 4407 31 , , , cord-005453-4057qib7 4407 32 for for IN cord-005453-4057qib7 4407 33 a a DT cord-005453-4057qib7 4407 34 significant significant JJ cord-005453-4057qib7 4407 35 number number NN cord-005453-4057qib7 4407 36 of of IN cord-005453-4057qib7 4407 37 patients patient NNS cord-005453-4057qib7 4407 38 the the DT cord-005453-4057qib7 4407 39 syndrome syndrome NN cord-005453-4057qib7 4407 40 was be VBD cord-005453-4057qib7 4407 41 a a DT cord-005453-4057qib7 4407 42 reversible reversible JJ cord-005453-4057qib7 4407 43 . . . cord-005453-4057qib7 4408 1 For for IN cord-005453-4057qib7 4408 2 patients patient NNS cord-005453-4057qib7 4408 3 with with IN cord-005453-4057qib7 4408 4 high high JJ cord-005453-4057qib7 4408 5 risk risk NN cord-005453-4057qib7 4408 6 features feature NNS cord-005453-4057qib7 4408 7 ( ( -LRB- cord-005453-4057qib7 4408 8 BMI>25kg BMI>25kg NNP cord-005453-4057qib7 4408 9 / / SYM cord-005453-4057qib7 4408 10 m m NN cord-005453-4057qib7 4408 11 2 2 CD cord-005453-4057qib7 4408 12 , , , cord-005453-4057qib7 4408 13 age age NN cord-005453-4057qib7 4408 14 > > XX cord-005453-4057qib7 4408 15 35 35 CD cord-005453-4057qib7 4408 16 years year NNS cord-005453-4057qib7 4408 17 , , , cord-005453-4057qib7 4408 18 known know VBN cord-005453-4057qib7 4408 19 history history NN cord-005453-4057qib7 4408 20 of of IN cord-005453-4057qib7 4408 21 diabetes diabetes NN cord-005453-4057qib7 4408 22 - - HYPH cord-005453-4057qib7 4408 23 mellitus mellitus NN cord-005453-4057qib7 4408 24 , , , cord-005453-4057qib7 4408 25 dyslipidemia dyslipidemia NN cord-005453-4057qib7 4408 26 , , , cord-005453-4057qib7 4408 27 hypertension hypertension NN cord-005453-4057qib7 4408 28 ) ) -RRB- cord-005453-4057qib7 4408 29 apart apart RB cord-005453-4057qib7 4408 30 of of IN cord-005453-4057qib7 4408 31 close close JJ cord-005453-4057qib7 4408 32 monitoring monitoring NN cord-005453-4057qib7 4408 33 , , , cord-005453-4057qib7 4408 34 specific specific JJ cord-005453-4057qib7 4408 35 diet diet NN cord-005453-4057qib7 4408 36 and and CC cord-005453-4057qib7 4408 37 encouragement encouragement NN cord-005453-4057qib7 4408 38 for for IN cord-005453-4057qib7 4408 39 adequate adequate JJ cord-005453-4057qib7 4408 40 exercise exercise NN cord-005453-4057qib7 4408 41 might may MD cord-005453-4057qib7 4408 42 help help VB cord-005453-4057qib7 4408 43 to to TO cord-005453-4057qib7 4408 44 reduce reduce VB cord-005453-4057qib7 4408 45 the the DT cord-005453-4057qib7 4408 46 incidence incidence NN cord-005453-4057qib7 4408 47 and and CC cord-005453-4057qib7 4408 48 the the DT cord-005453-4057qib7 4408 49 severity severity NN cord-005453-4057qib7 4408 50 of of IN cord-005453-4057qib7 4408 51 PT PT NNP cord-005453-4057qib7 4408 52 - - HYPH cord-005453-4057qib7 4408 53 MS MS NNP cord-005453-4057qib7 4408 54 . . . cord-005453-4057qib7 4409 1 Nevertheless nevertheless RB cord-005453-4057qib7 4409 2 , , , cord-005453-4057qib7 4409 3 prospective prospective JJ cord-005453-4057qib7 4409 4 and and CC cord-005453-4057qib7 4409 5 well well JJ cord-005453-4057qib7 4409 6 design design NN cord-005453-4057qib7 4409 7 trials trial NNS cord-005453-4057qib7 4409 8 are be VBP cord-005453-4057qib7 4409 9 warranted warrant VBN cord-005453-4057qib7 4409 10 to to TO cord-005453-4057qib7 4409 11 determine determine VB cord-005453-4057qib7 4409 12 the the DT cord-005453-4057qib7 4409 13 accurate accurate JJ cord-005453-4057qib7 4409 14 incidence incidence NN cord-005453-4057qib7 4409 15 , , , cord-005453-4057qib7 4409 16 severity severity NN cord-005453-4057qib7 4409 17 and and CC cord-005453-4057qib7 4409 18 the the DT cord-005453-4057qib7 4409 19 impact impact NN cord-005453-4057qib7 4409 20 of of IN cord-005453-4057qib7 4409 21 PT PT NNP cord-005453-4057qib7 4409 22 - - HYPH cord-005453-4057qib7 4409 23 MS MS NNP cord-005453-4057qib7 4409 24 on on IN cord-005453-4057qib7 4409 25 the the DT cord-005453-4057qib7 4409 26 alloSCT alloSCT NNP cord-005453-4057qib7 4409 27 outcome outcome NN cord-005453-4057qib7 4409 28 . . . cord-005453-4057qib7 4410 1 Disclosure disclosure NN cord-005453-4057qib7 4410 2 : : : cord-005453-4057qib7 4410 3 No no DT cord-005453-4057qib7 4410 4 conflict conflict NN cord-005453-4057qib7 4411 1 ofinterest ofinterest NNP cord-005453-4057qib7 4411 2 Experience experience NN cord-005453-4057qib7 4411 3 of of IN cord-005453-4057qib7 4411 4 a a DT cord-005453-4057qib7 4411 5 single single JJ cord-005453-4057qib7 4411 6 center center NN cord-005453-4057qib7 4411 7 in in IN cord-005453-4057qib7 4411 8 the the DT cord-005453-4057qib7 4411 9 humanization humanization NN cord-005453-4057qib7 4411 10 of of IN cord-005453-4057qib7 4411 11 the the DT cord-005453-4057qib7 4411 12 hospitalization hospitalization NN cord-005453-4057qib7 4411 13 process process NN cord-005453-4057qib7 4411 14 : : : cord-005453-4057qib7 4412 1 Technology technology NN cord-005453-4057qib7 4412 2 and and CC cord-005453-4057qib7 4412 3 team team NN cord-005453-4057qib7 4412 4 training training NN cord-005453-4057qib7 4412 5 impact impact NN cord-005453-4057qib7 4412 6 on on IN cord-005453-4057qib7 4412 7 the the DT cord-005453-4057qib7 4412 8 QOL QOL NNP cord-005453-4057qib7 4412 9 of of IN cord-005453-4057qib7 4412 10 the the DT cord-005453-4057qib7 4412 11 patient patient NN cord-005453-4057qib7 4412 12 and and CC cord-005453-4057qib7 4412 13 family family NN cord-005453-4057qib7 4412 14 Maria Maria NNP cord-005453-4057qib7 4412 15 Claudia Claudia NNP cord-005453-4057qib7 4412 16 Moreira Moreira NNP cord-005453-4057qib7 4412 17 1 1 CD cord-005453-4057qib7 4412 18 , , , cord-005453-4057qib7 4412 19 Marcia Marcia NNP cord-005453-4057qib7 4412 20 Rejane Rejane NNP cord-005453-4057qib7 4412 21 1 1 CD cord-005453-4057qib7 4412 22 , , , cord-005453-4057qib7 4412 23 Marcia Marcia NNP cord-005453-4057qib7 4412 24 Garnica Garnica NNP cord-005453-4057qib7 4412 25 1 1 CD cord-005453-4057qib7 4412 26 , , , cord-005453-4057qib7 4412 27 Andrea Andrea NNP cord-005453-4057qib7 4412 28 Ribeiro Ribeiro NNP cord-005453-4057qib7 4412 29 1 1 CD cord-005453-4057qib7 4412 30 , , , cord-005453-4057qib7 4412 31 Paulo Paulo NNP cord-005453-4057qib7 4412 32 Cesar Cesar NNP cord-005453-4057qib7 4412 33 Dias Dias NNP cord-005453-4057qib7 4412 34 1 1 CD cord-005453-4057qib7 4412 35 , , , cord-005453-4057qib7 4412 36 Ilza Ilza NNP cord-005453-4057qib7 4412 37 Fellows Fellows NNP cord-005453-4057qib7 4413 1 1 1 CD cord-005453-4057qib7 4413 2 Background background NN cord-005453-4057qib7 4413 3 : : : cord-005453-4057qib7 4414 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 4414 2 stem stem NN cord-005453-4057qib7 4414 3 cell cell NN cord-005453-4057qib7 4414 4 transplantation transplantation NN cord-005453-4057qib7 4414 5 ( ( -LRB- cord-005453-4057qib7 4414 6 HSCT HSCT NNP cord-005453-4057qib7 4414 7 ) ) -RRB- cord-005453-4057qib7 4414 8 is be VBZ cord-005453-4057qib7 4414 9 one one CD cord-005453-4057qib7 4414 10 of of IN cord-005453-4057qib7 4414 11 the the DT cord-005453-4057qib7 4414 12 most most RBS cord-005453-4057qib7 4414 13 aggressive aggressive JJ cord-005453-4057qib7 4414 14 therapeutic therapeutic JJ cord-005453-4057qib7 4414 15 modalities modality NNS cord-005453-4057qib7 4414 16 of of IN cord-005453-4057qib7 4414 17 internal internal JJ cord-005453-4057qib7 4414 18 medicine medicine NN cord-005453-4057qib7 4414 19 , , , cord-005453-4057qib7 4414 20 making make VBG cord-005453-4057qib7 4414 21 it -PRON- PRP cord-005453-4057qib7 4414 22 a a DT cord-005453-4057qib7 4414 23 highly highly RB cord-005453-4057qib7 4414 24 stressful stressful JJ cord-005453-4057qib7 4414 25 experience experience NN cord-005453-4057qib7 4414 26 for for IN cord-005453-4057qib7 4414 27 the the DT cord-005453-4057qib7 4414 28 patient patient NN cord-005453-4057qib7 4414 29 and and CC cord-005453-4057qib7 4414 30 his -PRON- PRP$ cord-005453-4057qib7 4414 31 family family NN cord-005453-4057qib7 4414 32 . . . cord-005453-4057qib7 4415 1 The the DT cord-005453-4057qib7 4415 2 duration duration NN cord-005453-4057qib7 4415 3 of of IN cord-005453-4057qib7 4415 4 hospitalization hospitalization NN cord-005453-4057qib7 4415 5 can can MD cord-005453-4057qib7 4415 6 be be VB cord-005453-4057qib7 4415 7 prolonged prolong VBN cord-005453-4057qib7 4415 8 by by IN cord-005453-4057qib7 4415 9 several several JJ cord-005453-4057qib7 4415 10 intercurrences intercurrence NNS cord-005453-4057qib7 4415 11 , , , cord-005453-4057qib7 4415 12 frequently frequently RB cord-005453-4057qib7 4415 13 generating generate VBG cord-005453-4057qib7 4415 14 anxiety anxiety NN cord-005453-4057qib7 4415 15 in in IN cord-005453-4057qib7 4415 16 the the DT cord-005453-4057qib7 4415 17 patient patient NN cord-005453-4057qib7 4415 18 and and CC cord-005453-4057qib7 4415 19 their -PRON- PRP$ cord-005453-4057qib7 4415 20 caregiver caregiver NN cord-005453-4057qib7 4415 21 , , , cord-005453-4057qib7 4415 22 which which WDT cord-005453-4057qib7 4415 23 may may MD cord-005453-4057qib7 4415 24 lead lead VB cord-005453-4057qib7 4415 25 to to IN cord-005453-4057qib7 4415 26 confinement confinement NN cord-005453-4057qib7 4415 27 and and CC cord-005453-4057qib7 4415 28 reactive reactive JJ cord-005453-4057qib7 4415 29 depression depression NN cord-005453-4057qib7 4415 30 . . . cord-005453-4057qib7 4416 1 Interventions intervention NNS cord-005453-4057qib7 4416 2 in in IN cord-005453-4057qib7 4416 3 the the DT cord-005453-4057qib7 4416 4 hospital hospital NN cord-005453-4057qib7 4416 5 environment environment NN cord-005453-4057qib7 4416 6 , , , cord-005453-4057qib7 4416 7 in in IN cord-005453-4057qib7 4416 8 addition addition NN cord-005453-4057qib7 4416 9 to to IN cord-005453-4057qib7 4416 10 the the DT cord-005453-4057qib7 4416 11 continuous continuous JJ cord-005453-4057qib7 4416 12 training training NN cord-005453-4057qib7 4416 13 of of IN cord-005453-4057qib7 4416 14 the the DT cord-005453-4057qib7 4416 15 multidisciplinary multidisciplinary JJ cord-005453-4057qib7 4416 16 team team NN cord-005453-4057qib7 4416 17 , , , cord-005453-4057qib7 4416 18 can can MD cord-005453-4057qib7 4416 19 have have VB cord-005453-4057qib7 4416 20 a a DT cord-005453-4057qib7 4416 21 positive positive JJ cord-005453-4057qib7 4416 22 impact impact NN cord-005453-4057qib7 4416 23 in in IN cord-005453-4057qib7 4416 24 this this DT cord-005453-4057qib7 4416 25 process process NN cord-005453-4057qib7 4416 26 with with IN cord-005453-4057qib7 4416 27 improvement improvement NN cord-005453-4057qib7 4416 28 in in IN cord-005453-4057qib7 4416 29 the the DT cord-005453-4057qib7 4416 30 process process NN cord-005453-4057qib7 4416 31 of of IN cord-005453-4057qib7 4416 32 discharge discharge NN cord-005453-4057qib7 4416 33 and and CC cord-005453-4057qib7 4416 34 quality quality NN cord-005453-4057qib7 4416 35 of of IN cord-005453-4057qib7 4416 36 life life NN cord-005453-4057qib7 4416 37 of of IN cord-005453-4057qib7 4416 38 the the DT cord-005453-4057qib7 4416 39 patient patient NN cord-005453-4057qib7 4416 40 and and CC cord-005453-4057qib7 4416 41 his -PRON- PRP$ cord-005453-4057qib7 4416 42 / / SYM cord-005453-4057qib7 4416 43 her -PRON- PRP$ cord-005453-4057qib7 4416 44 family family NN cord-005453-4057qib7 4416 45 . . . cord-005453-4057qib7 4417 1 Methods method NNS cord-005453-4057qib7 4417 2 : : : cord-005453-4057qib7 4418 1 The the DT cord-005453-4057qib7 4418 2 objective objective NN cord-005453-4057qib7 4418 3 of of IN cord-005453-4057qib7 4418 4 this this DT cord-005453-4057qib7 4418 5 research research NN cord-005453-4057qib7 4418 6 was be VBD cord-005453-4057qib7 4418 7 to to TO cord-005453-4057qib7 4418 8 evaluate evaluate VB cord-005453-4057qib7 4418 9 the the DT cord-005453-4057qib7 4418 10 impact impact NN cord-005453-4057qib7 4418 11 of of IN cord-005453-4057qib7 4418 12 a a DT cord-005453-4057qib7 4418 13 reformulation reformulation NN cord-005453-4057qib7 4418 14 in in IN cord-005453-4057qib7 4418 15 the the DT cord-005453-4057qib7 4418 16 unit unit NN cord-005453-4057qib7 4418 17 , , , cord-005453-4057qib7 4418 18 completed complete VBN cord-005453-4057qib7 4418 19 in in IN cord-005453-4057qib7 4418 20 May May NNP cord-005453-4057qib7 4418 21 2018 2018 CD cord-005453-4057qib7 4418 22 , , , cord-005453-4057qib7 4418 23 which which WDT cord-005453-4057qib7 4418 24 modified modify VBD cord-005453-4057qib7 4418 25 the the DT cord-005453-4057qib7 4418 26 facilities facility NNS cord-005453-4057qib7 4418 27 with with IN cord-005453-4057qib7 4418 28 availability availability NN cord-005453-4057qib7 4418 29 of of IN cord-005453-4057qib7 4418 30 hermetic hermetic JJ cord-005453-4057qib7 4418 31 balconies balcony NNS cord-005453-4057qib7 4418 32 in in IN cord-005453-4057qib7 4418 33 each each DT cord-005453-4057qib7 4418 34 room room NN cord-005453-4057qib7 4418 35 , , , cord-005453-4057qib7 4418 36 with with IN cord-005453-4057qib7 4418 37 a a DT cord-005453-4057qib7 4418 38 view view NN cord-005453-4057qib7 4418 39 of of IN cord-005453-4057qib7 4418 40 an an DT cord-005453-4057qib7 4418 41 internal internal JJ cord-005453-4057qib7 4418 42 garden garden NN cord-005453-4057qib7 4418 43 . . . cord-005453-4057qib7 4419 1 There there EX cord-005453-4057qib7 4419 2 was be VBD cord-005453-4057qib7 4419 3 also also RB cord-005453-4057qib7 4419 4 the the DT cord-005453-4057qib7 4419 5 addition addition NN cord-005453-4057qib7 4419 6 of of IN cord-005453-4057qib7 4419 7 a a DT cord-005453-4057qib7 4419 8 screen screen NN cord-005453-4057qib7 4419 9 in in IN cord-005453-4057qib7 4419 10 the the DT cord-005453-4057qib7 4419 11 corridor corridor NN cord-005453-4057qib7 4419 12 of of IN cord-005453-4057qib7 4419 13 the the DT cord-005453-4057qib7 4419 14 floor floor NN cord-005453-4057qib7 4419 15 with with IN cord-005453-4057qib7 4419 16 images image NNS cord-005453-4057qib7 4419 17 -technology -technology WP cord-005453-4057qib7 4419 18 known know VBN cord-005453-4057qib7 4419 19 as as IN cord-005453-4057qib7 4419 20 videoowall videoowall NNP cord-005453-4057qib7 4419 21 , , , cord-005453-4057qib7 4419 22 interconnected interconnect VBN cord-005453-4057qib7 4419 23 to to IN cord-005453-4057qib7 4419 24 motion motion NN cord-005453-4057qib7 4419 25 sensors sensor NNS cord-005453-4057qib7 4419 26 ( ( -LRB- cord-005453-4057qib7 4419 27 kinects kinect NNS cord-005453-4057qib7 4419 28 ) ) -RRB- cord-005453-4057qib7 4419 29 that that WDT cord-005453-4057qib7 4419 30 allow allow VBP cord-005453-4057qib7 4419 31 interaction interaction NN cord-005453-4057qib7 4419 32 between between IN cord-005453-4057qib7 4419 33 patients patient NNS cord-005453-4057qib7 4419 34 and and CC cord-005453-4057qib7 4419 35 families family NNS cord-005453-4057qib7 4419 36 , , , cord-005453-4057qib7 4419 37 besides besides IN cord-005453-4057qib7 4419 38 facilitating facilitate VBG cord-005453-4057qib7 4419 39 physiotherapy physiotherapy NN cord-005453-4057qib7 4419 40 and and CC cord-005453-4057qib7 4419 41 physical physical JJ cord-005453-4057qib7 4419 42 exercise exercise NN cord-005453-4057qib7 4419 43 . . . cord-005453-4057qib7 4420 1 There there EX cord-005453-4057qib7 4420 2 was be VBD cord-005453-4057qib7 4420 3 re re NN cord-005453-4057qib7 4420 4 - - NN cord-005453-4057qib7 4420 5 training training NN cord-005453-4057qib7 4420 6 of of IN cord-005453-4057qib7 4420 7 the the DT cord-005453-4057qib7 4420 8 multidisciplinary multidisciplinary JJ cord-005453-4057qib7 4420 9 team team NN cord-005453-4057qib7 4420 10 with with IN cord-005453-4057qib7 4420 11 emphasis emphasis NN cord-005453-4057qib7 4420 12 on on IN cord-005453-4057qib7 4420 13 the the DT cord-005453-4057qib7 4420 14 practice practice NN cord-005453-4057qib7 4420 15 of of IN cord-005453-4057qib7 4420 16 humanization humanization NN cord-005453-4057qib7 4420 17 . . . cord-005453-4057qib7 4421 1 The the DT cord-005453-4057qib7 4421 2 methodology methodology NN cord-005453-4057qib7 4421 3 consisted consist VBD cord-005453-4057qib7 4421 4 in in IN cord-005453-4057qib7 4421 5 the the DT cord-005453-4057qib7 4421 6 application application NN cord-005453-4057qib7 4421 7 of of IN cord-005453-4057qib7 4421 8 questionnaires questionnaire NNS cord-005453-4057qib7 4421 9 of of IN cord-005453-4057qib7 4421 10 satisfaction satisfaction NN cord-005453-4057qib7 4421 11 to to IN cord-005453-4057qib7 4421 12 patients patient NNS cord-005453-4057qib7 4421 13 and and CC cord-005453-4057qib7 4421 14 their -PRON- PRP$ cord-005453-4057qib7 4421 15 families family NNS cord-005453-4057qib7 4421 16 during during IN cord-005453-4057qib7 4421 17 the the DT cord-005453-4057qib7 4421 18 period period NN cord-005453-4057qib7 4421 19 of of IN cord-005453-4057qib7 4421 20 hospitalization hospitalization NN cord-005453-4057qib7 4421 21 in in IN cord-005453-4057qib7 4421 22 a a DT cord-005453-4057qib7 4421 23 bone bone NN cord-005453-4057qib7 4421 24 marrow marrow NN cord-005453-4057qib7 4421 25 transplant transplant NN cord-005453-4057qib7 4421 26 unit unit NN cord-005453-4057qib7 4421 27 in in IN cord-005453-4057qib7 4421 28 the the DT cord-005453-4057qib7 4421 29 third third JJ cord-005453-4057qib7 4421 30 quarter quarter NN cord-005453-4057qib7 4421 31 of of IN cord-005453-4057qib7 4421 32 2018 2018 CD cord-005453-4057qib7 4421 33 . . . cord-005453-4057qib7 4422 1 The the DT cord-005453-4057qib7 4422 2 items item NNS cord-005453-4057qib7 4422 3 evaluated evaluate VBD cord-005453-4057qib7 4422 4 ranged range VBD cord-005453-4057qib7 4422 5 from from IN cord-005453-4057qib7 4422 6 the the DT cord-005453-4057qib7 4422 7 quality quality NN cord-005453-4057qib7 4422 8 of of IN cord-005453-4057qib7 4422 9 the the DT cord-005453-4057qib7 4422 10 information information NN cord-005453-4057qib7 4422 11 provided provide VBN cord-005453-4057qib7 4422 12 by by IN cord-005453-4057qib7 4422 13 the the DT cord-005453-4057qib7 4422 14 medical medical JJ cord-005453-4057qib7 4422 15 team team NN cord-005453-4057qib7 4422 16 and and CC cord-005453-4057qib7 4422 17 nursing nursing NN cord-005453-4057qib7 4422 18 , , , cord-005453-4057qib7 4422 19 to to IN cord-005453-4057qib7 4422 20 the the DT cord-005453-4057qib7 4422 21 cordiality cordiality NN cord-005453-4057qib7 4422 22 and and CC cord-005453-4057qib7 4422 23 agility agility NN cord-005453-4057qib7 4422 24 with with IN cord-005453-4057qib7 4422 25 which which WDT cord-005453-4057qib7 4422 26 the the DT cord-005453-4057qib7 4422 27 patient patient NN cord-005453-4057qib7 4422 28 and and CC cord-005453-4057qib7 4422 29 his -PRON- PRP$ cord-005453-4057qib7 4422 30 patient patient NN cord-005453-4057qib7 4422 31 were be VBD cord-005453-4057qib7 4422 32 treated treat VBN cord-005453-4057qib7 4422 33 by by IN cord-005453-4057qib7 4422 34 the the DT cord-005453-4057qib7 4422 35 global global JJ cord-005453-4057qib7 4422 36 team team NN cord-005453-4057qib7 4422 37 . . . cord-005453-4057qib7 4423 1 The the DT cord-005453-4057qib7 4423 2 results result NNS cord-005453-4057qib7 4423 3 were be VBD cord-005453-4057qib7 4423 4 compared compare VBN cord-005453-4057qib7 4423 5 with with IN cord-005453-4057qib7 4423 6 a a DT cord-005453-4057qib7 4423 7 similar similar JJ cord-005453-4057qib7 4423 8 period period NN cord-005453-4057qib7 4423 9 of of IN cord-005453-4057qib7 4423 10 the the DT cord-005453-4057qib7 4423 11 same same JJ cord-005453-4057qib7 4423 12 unit unit NN cord-005453-4057qib7 4423 13 in in IN cord-005453-4057qib7 4423 14 the the DT cord-005453-4057qib7 4423 15 previous previous JJ cord-005453-4057qib7 4423 16 year year NN cord-005453-4057qib7 4423 17 and and CC cord-005453-4057qib7 4423 18 with with IN cord-005453-4057qib7 4423 19 the the DT cord-005453-4057qib7 4423 20 indices index NNS cord-005453-4057qib7 4423 21 collected collect VBN cord-005453-4057qib7 4423 22 simultaneously simultaneously RB cord-005453-4057qib7 4423 23 in in IN cord-005453-4057qib7 4423 24 another another DT cord-005453-4057qib7 4423 25 unit unit NN cord-005453-4057qib7 4423 26 of of IN cord-005453-4057qib7 4423 27 the the DT cord-005453-4057qib7 4423 28 same same JJ cord-005453-4057qib7 4423 29 hospital hospital NN cord-005453-4057qib7 4423 30 ( ( -LRB- cord-005453-4057qib7 4423 31 cardio cardio NN cord-005453-4057qib7 4423 32 - - HYPH cord-005453-4057qib7 4423 33 intensive intensive JJ cord-005453-4057qib7 4423 34 ) ) -RRB- cord-005453-4057qib7 4423 35 . . . cord-005453-4057qib7 4424 1 Results result NNS cord-005453-4057qib7 4424 2 : : : cord-005453-4057qib7 4425 1 Overall overall JJ cord-005453-4057qib7 4425 2 and and CC cord-005453-4057qib7 4425 3 segmental segmental JJ cord-005453-4057qib7 4425 4 satisfaction satisfaction NN cord-005453-4057qib7 4425 5 scores score NNS cord-005453-4057qib7 4425 6 in in IN cord-005453-4057qib7 4425 7 the the DT cord-005453-4057qib7 4425 8 various various JJ cord-005453-4057qib7 4425 9 items item NNS cord-005453-4057qib7 4425 10 surveyed survey VBN cord-005453-4057qib7 4425 11 were be VBD cord-005453-4057qib7 4425 12 higher high JJR cord-005453-4057qib7 4425 13 when when WRB cord-005453-4057qib7 4425 14 compared compare VBN cord-005453-4057qib7 4425 15 to to IN cord-005453-4057qib7 4425 16 the the DT cord-005453-4057qib7 4425 17 previous previous JJ cord-005453-4057qib7 4425 18 period period NN cord-005453-4057qib7 4425 19 of of IN cord-005453-4057qib7 4425 20 the the DT cord-005453-4057qib7 4425 21 same same JJ cord-005453-4057qib7 4425 22 unit unit NN cord-005453-4057qib7 4425 23 and and CC cord-005453-4057qib7 4425 24 were be VBD cord-005453-4057qib7 4425 25 also also RB cord-005453-4057qib7 4425 26 higher high JJR cord-005453-4057qib7 4425 27 in in IN cord-005453-4057qib7 4425 28 those those DT cord-005453-4057qib7 4425 29 obtained obtain VBN cord-005453-4057qib7 4425 30 in in IN cord-005453-4057qib7 4425 31 a a DT cord-005453-4057qib7 4425 32 high high JJ cord-005453-4057qib7 4425 33 complexity complexity NN cord-005453-4057qib7 4425 34 unit unit NN cord-005453-4057qib7 4425 35 of of IN cord-005453-4057qib7 4425 36 the the DT cord-005453-4057qib7 4425 37 same same JJ cord-005453-4057qib7 4425 38 hospital hospital NN cord-005453-4057qib7 4425 39 , , , cord-005453-4057qib7 4425 40 composed compose VBN cord-005453-4057qib7 4425 41 of of IN cord-005453-4057qib7 4425 42 patients patient NNS cord-005453-4057qib7 4425 43 submitted submit VBN cord-005453-4057qib7 4425 44 to to IN cord-005453-4057qib7 4425 45 mental mental JJ cord-005453-4057qib7 4425 46 and and CC cord-005453-4057qib7 4425 47 psychological psychological JJ cord-005453-4057qib7 4425 48 stress stress NN cord-005453-4057qib7 4425 49 similar similar JJ cord-005453-4057qib7 4425 50 to to IN cord-005453-4057qib7 4425 51 onco onco NNP cord-005453-4057qib7 4425 52 - - HYPH cord-005453-4057qib7 4425 53 hematologicos hematologicos NNP cord-005453-4057qib7 4425 54 . . . cord-005453-4057qib7 4426 1 A a DT cord-005453-4057qib7 4426 2 reports report NNS cord-005453-4057qib7 4426 3 of of IN cord-005453-4057qib7 4426 4 " " `` cord-005453-4057qib7 4426 5 free free JJ cord-005453-4057qib7 4426 6 speech speech NN cord-005453-4057qib7 4426 7 " " '' cord-005453-4057qib7 4426 8 were be VBD cord-005453-4057qib7 4426 9 also also RB cord-005453-4057qib7 4426 10 obtained obtain VBN cord-005453-4057qib7 4426 11 anonymously anonymously RB cord-005453-4057qib7 4426 12 , , , cord-005453-4057qib7 4426 13 in in IN cord-005453-4057qib7 4426 14 order order NN cord-005453-4057qib7 4426 15 to to TO cord-005453-4057qib7 4426 16 guarantee guarantee VB cord-005453-4057qib7 4426 17 the the DT cord-005453-4057qib7 4426 18 authenticity authenticity NN cord-005453-4057qib7 4426 19 and and CC cord-005453-4057qib7 4426 20 free free JJ cord-005453-4057qib7 4426 21 expression expression NN cord-005453-4057qib7 4426 22 of of IN cord-005453-4057qib7 4426 23 the the DT cord-005453-4057qib7 4426 24 subjects subject NNS cord-005453-4057qib7 4426 25 analyzed analyze VBN cord-005453-4057qib7 4426 26 . . . cord-005453-4057qib7 4427 1 Conclusions conclusion NNS cord-005453-4057qib7 4427 2 : : : cord-005453-4057qib7 4428 1 The the DT cord-005453-4057qib7 4428 2 results result NNS cord-005453-4057qib7 4428 3 obtained obtain VBN cord-005453-4057qib7 4428 4 allowed allow VBD cord-005453-4057qib7 4428 5 the the DT cord-005453-4057qib7 4428 6 validation validation NN cord-005453-4057qib7 4428 7 of of IN cord-005453-4057qib7 4428 8 the the DT cord-005453-4057qib7 4428 9 technical technical JJ cord-005453-4057qib7 4428 10 and and CC cord-005453-4057qib7 4428 11 professional professional JJ cord-005453-4057qib7 4428 12 team team NN cord-005453-4057qib7 4428 13 initiatives initiative NNS cord-005453-4057qib7 4428 14 , , , cord-005453-4057qib7 4428 15 bringing bring VBG cord-005453-4057qib7 4428 16 indicators indicator NNS cord-005453-4057qib7 4428 17 that that WDT cord-005453-4057qib7 4428 18 will will MD cord-005453-4057qib7 4428 19 allow allow VB cord-005453-4057qib7 4428 20 better well JJR cord-005453-4057qib7 4428 21 monitoring monitoring NN cord-005453-4057qib7 4428 22 and and CC cord-005453-4057qib7 4428 23 support support NN cord-005453-4057qib7 4428 24 of of IN cord-005453-4057qib7 4428 25 these these DT cord-005453-4057qib7 4428 26 patients patient NNS cord-005453-4057qib7 4428 27 and and CC cord-005453-4057qib7 4428 28 their -PRON- PRP$ cord-005453-4057qib7 4428 29 relatives relative NNS cord-005453-4057qib7 4428 30 in in IN cord-005453-4057qib7 4428 31 this this DT cord-005453-4057qib7 4428 32 difficult difficult JJ cord-005453-4057qib7 4428 33 time time NN cord-005453-4057qib7 4428 34 of of IN cord-005453-4057qib7 4428 35 treatment treatment NN cord-005453-4057qib7 4428 36 . . . cord-005453-4057qib7 4429 1 They -PRON- PRP cord-005453-4057qib7 4429 2 served serve VBD cord-005453-4057qib7 4429 3 as as IN cord-005453-4057qib7 4429 4 an an DT cord-005453-4057qib7 4429 5 initial initial JJ cord-005453-4057qib7 4429 6 tool tool NN cord-005453-4057qib7 4429 7 in in IN cord-005453-4057qib7 4429 8 the the DT cord-005453-4057qib7 4429 9 continuous continuous JJ cord-005453-4057qib7 4429 10 process process NN cord-005453-4057qib7 4429 11 of of IN cord-005453-4057qib7 4429 12 humanization humanization NN cord-005453-4057qib7 4429 13 and and CC cord-005453-4057qib7 4429 14 stimulated stimulate VBD cord-005453-4057qib7 4429 15 the the DT cord-005453-4057qib7 4429 16 multidisciplinary multidisciplinary JJ cord-005453-4057qib7 4429 17 team team NN cord-005453-4057qib7 4429 18 to to TO cord-005453-4057qib7 4429 19 continuously continuously RB cord-005453-4057qib7 4429 20 improve improve VB cord-005453-4057qib7 4429 21 this this DT cord-005453-4057qib7 4429 22 process process NN cord-005453-4057qib7 4429 23 . . . cord-005453-4057qib7 4430 1 Disclosure disclosure NN cord-005453-4057qib7 4430 2 Background background NN cord-005453-4057qib7 4430 3 : : : cord-005453-4057qib7 4430 4 Pure pure JJ cord-005453-4057qib7 4430 5 red red JJ cord-005453-4057qib7 4430 6 cell cell NN cord-005453-4057qib7 4430 7 anemia anemia NN cord-005453-4057qib7 4430 8 ( ( -LRB- cord-005453-4057qib7 4430 9 PRCA PRCA NNP cord-005453-4057qib7 4430 10 ) ) -RRB- cord-005453-4057qib7 4430 11 is be VBZ cord-005453-4057qib7 4430 12 a a DT cord-005453-4057qib7 4430 13 rare rare JJ cord-005453-4057qib7 4430 14 complication complication NN cord-005453-4057qib7 4430 15 of of IN cord-005453-4057qib7 4430 16 ABO ABO NNP cord-005453-4057qib7 4430 17 - - HYPH cord-005453-4057qib7 4430 18 incopatible incopatible JJ cord-005453-4057qib7 4430 19 hematopoetic hematopoetic JJ cord-005453-4057qib7 4430 20 stem stem NN cord-005453-4057qib7 4430 21 cell cell NN cord-005453-4057qib7 4430 22 transplantation transplantation NN cord-005453-4057qib7 4430 23 characterized characterize VBN cord-005453-4057qib7 4430 24 by by IN cord-005453-4057qib7 4430 25 anemia anemia NN cord-005453-4057qib7 4430 26 , , , cord-005453-4057qib7 4430 27 reticulocytopenia reticulocytopenia NN cord-005453-4057qib7 4430 28 and and CC cord-005453-4057qib7 4430 29 absence absence NN cord-005453-4057qib7 4430 30 of of IN cord-005453-4057qib7 4430 31 erythroid erythroid NN cord-005453-4057qib7 4430 32 precursors precursor NNS cord-005453-4057qib7 4430 33 in in IN cord-005453-4057qib7 4430 34 patient patient NN cord-005453-4057qib7 4430 35 's 's POS cord-005453-4057qib7 4430 36 bone bone NN cord-005453-4057qib7 4430 37 marrow marrow NN cord-005453-4057qib7 4430 38 . . . cord-005453-4057qib7 4431 1 Most Most JJS cord-005453-4057qib7 4431 2 patients patient NNS cord-005453-4057qib7 4431 3 with with IN cord-005453-4057qib7 4431 4 PRCA PRCA NNP cord-005453-4057qib7 4431 5 resolve resolve VB cord-005453-4057qib7 4431 6 spontaneously spontaneously RB cord-005453-4057qib7 4431 7 within within IN cord-005453-4057qib7 4431 8 months month NNS cord-005453-4057qib7 4431 9 , , , cord-005453-4057qib7 4431 10 however however RB cord-005453-4057qib7 4431 11 a a DT cord-005453-4057qib7 4431 12 small small JJ cord-005453-4057qib7 4431 13 number number NN cord-005453-4057qib7 4431 14 of of IN cord-005453-4057qib7 4431 15 patients patient NNS cord-005453-4057qib7 4431 16 requires require VBZ cord-005453-4057qib7 4431 17 continued continued JJ cord-005453-4057qib7 4431 18 red red JJ cord-005453-4057qib7 4431 19 blood blood NN cord-005453-4057qib7 4431 20 cell cell NN cord-005453-4057qib7 4431 21 ( ( -LRB- cord-005453-4057qib7 4431 22 RBC RBC NNP cord-005453-4057qib7 4431 23 ) ) -RRB- cord-005453-4057qib7 4431 24 transfusions transfusion NNS cord-005453-4057qib7 4431 25 . . . cord-005453-4057qib7 4432 1 The the DT cord-005453-4057qib7 4432 2 treatment treatment NN cord-005453-4057qib7 4432 3 of of IN cord-005453-4057qib7 4432 4 this this DT cord-005453-4057qib7 4432 5 complication complication NN cord-005453-4057qib7 4432 6 is be VBZ cord-005453-4057qib7 4432 7 difficult difficult JJ cord-005453-4057qib7 4432 8 and and CC cord-005453-4057qib7 4432 9 not not RB cord-005453-4057qib7 4432 10 standardized standardized JJ cord-005453-4057qib7 4432 11 . . . cord-005453-4057qib7 4433 1 Different different JJ cord-005453-4057qib7 4433 2 approaches approach NNS cord-005453-4057qib7 4433 3 has have VBZ cord-005453-4057qib7 4433 4 been be VBN cord-005453-4057qib7 4433 5 used use VBN cord-005453-4057qib7 4433 6 such such JJ cord-005453-4057qib7 4433 7 as as IN cord-005453-4057qib7 4433 8 Rituximab Rituximab NNP cord-005453-4057qib7 4433 9 , , , cord-005453-4057qib7 4433 10 donor donor NN cord-005453-4057qib7 4433 11 lymphocytes lymphocyte NNS cord-005453-4057qib7 4433 12 , , , cord-005453-4057qib7 4433 13 plasma plasma NN cord-005453-4057qib7 4433 14 exchange exchange NN cord-005453-4057qib7 4433 15 with with IN cord-005453-4057qib7 4433 16 different different JJ cord-005453-4057qib7 4433 17 outcome outcome NN cord-005453-4057qib7 4433 18 . . . cord-005453-4057qib7 4434 1 Recently recently RB cord-005453-4057qib7 4434 2 , , , cord-005453-4057qib7 4434 3 a a DT cord-005453-4057qib7 4434 4 remarkable remarkable JJ cord-005453-4057qib7 4434 5 response response NN cord-005453-4057qib7 4434 6 to to IN cord-005453-4057qib7 4434 7 treatment treatment NN cord-005453-4057qib7 4434 8 with with IN cord-005453-4057qib7 4434 9 bortezomib bortezomib NNP cord-005453-4057qib7 4434 10 has have VBZ cord-005453-4057qib7 4434 11 been be VBN cord-005453-4057qib7 4434 12 described describe VBN cord-005453-4057qib7 4434 13 in in IN cord-005453-4057qib7 4434 14 a a DT cord-005453-4057qib7 4434 15 case case NN cord-005453-4057qib7 4434 16 of of IN cord-005453-4057qib7 4434 17 PRCA PRCA NNP cord-005453-4057qib7 4434 18 . . . cord-005453-4057qib7 4435 1 Methods method NNS cord-005453-4057qib7 4436 1 : : : cord-005453-4057qib7 4436 2 We -PRON- PRP cord-005453-4057qib7 4436 3 reviewed review VBD cord-005453-4057qib7 4436 4 146 146 CD cord-005453-4057qib7 4436 5 patients patient NNS cord-005453-4057qib7 4436 6 who who WP cord-005453-4057qib7 4436 7 received receive VBD cord-005453-4057qib7 4436 8 an an DT cord-005453-4057qib7 4436 9 allogeneic allogeneic JJ cord-005453-4057qib7 4436 10 hematopoetic hematopoetic JJ cord-005453-4057qib7 4436 11 stem stem NN cord-005453-4057qib7 4436 12 cell cell NN cord-005453-4057qib7 4436 13 transplant transplant NN cord-005453-4057qib7 4436 14 ( ( -LRB- cord-005453-4057qib7 4436 15 HCT HCT NNP cord-005453-4057qib7 4436 16 ) ) -RRB- cord-005453-4057qib7 4436 17 between between IN cord-005453-4057qib7 4436 18 Januar Januar NNP cord-005453-4057qib7 4436 19 2012 2012 CD cord-005453-4057qib7 4436 20 and and CC cord-005453-4057qib7 4436 21 August August NNP cord-005453-4057qib7 4436 22 2018 2018 CD cord-005453-4057qib7 4436 23 at at IN cord-005453-4057qib7 4436 24 our -PRON- PRP$ cord-005453-4057qib7 4436 25 institution institution NN cord-005453-4057qib7 4436 26 . . . cord-005453-4057qib7 4437 1 Sixty sixty CD cord-005453-4057qib7 4437 2 eight eight CD cord-005453-4057qib7 4437 3 patients patient NNS cord-005453-4057qib7 4437 4 received receive VBD cord-005453-4057qib7 4437 5 a a DT cord-005453-4057qib7 4437 6 major major JJ cord-005453-4057qib7 4437 7 ABO ABO NNP cord-005453-4057qib7 4437 8 - - HYPH cord-005453-4057qib7 4437 9 mismached mismache VBN cord-005453-4057qib7 4437 10 HCT hct NN cord-005453-4057qib7 4437 11 . . . cord-005453-4057qib7 4438 1 PRCA PRCA NNP cord-005453-4057qib7 4438 2 was be VBD cord-005453-4057qib7 4438 3 defined define VBN cord-005453-4057qib7 4438 4 as as IN cord-005453-4057qib7 4438 5 a a DT cord-005453-4057qib7 4438 6 completely completely RB cord-005453-4057qib7 4438 7 absence absence NN cord-005453-4057qib7 4438 8 of of IN cord-005453-4057qib7 4438 9 erythroid erythroid JJ cord-005453-4057qib7 4438 10 precursors precursor NNS cord-005453-4057qib7 4438 11 on on IN cord-005453-4057qib7 4438 12 day day NN cord-005453-4057qib7 4438 13 +30 +30 CD cord-005453-4057qib7 4438 14 bone bone NN cord-005453-4057qib7 4438 15 marrow marrow NN cord-005453-4057qib7 4438 16 puncture puncture NN cord-005453-4057qib7 4438 17 , , , cord-005453-4057qib7 4438 18 with with IN cord-005453-4057qib7 4438 19 absence absence NN cord-005453-4057qib7 4438 20 of of IN cord-005453-4057qib7 4438 21 donor donor NN cord-005453-4057qib7 4438 22 red red JJ cord-005453-4057qib7 4438 23 cells cell NNS cord-005453-4057qib7 4438 24 and and CC cord-005453-4057qib7 4438 25 the the DT cord-005453-4057qib7 4438 26 recipient recipient NN cord-005453-4057qib7 4438 27 requiring require VBG cord-005453-4057qib7 4438 28 RBC RBC NNP cord-005453-4057qib7 4438 29 transfusion transfusion NN cord-005453-4057qib7 4438 30 . . . cord-005453-4057qib7 4439 1 Results result NNS cord-005453-4057qib7 4439 2 : : : cord-005453-4057qib7 4440 1 Only only RB cord-005453-4057qib7 4440 2 one one CD cord-005453-4057qib7 4440 3 patient patient NN cord-005453-4057qib7 4440 4 developed develop VBD cord-005453-4057qib7 4440 5 PRCA PRCA NNP cord-005453-4057qib7 4440 6 ( ( -LRB- cord-005453-4057qib7 4440 7 1.5 1.5 CD cord-005453-4057qib7 4440 8 % % NN cord-005453-4057qib7 4440 9 ) ) -RRB- cord-005453-4057qib7 4440 10 . . . cord-005453-4057qib7 4441 1 A a DT cord-005453-4057qib7 4441 2 18 18 CD cord-005453-4057qib7 4441 3 years year NNS cord-005453-4057qib7 4441 4 old old JJ cord-005453-4057qib7 4441 5 male male NN cord-005453-4057qib7 4441 6 received receive VBD cord-005453-4057qib7 4441 7 a a DT cord-005453-4057qib7 4441 8 myeloablative myeloablative JJ cord-005453-4057qib7 4441 9 HLA HLA NNP cord-005453-4057qib7 4441 10 - - HYPH cord-005453-4057qib7 4441 11 matched match VBN cord-005453-4057qib7 4441 12 ABOmismatched abomismatched JJ cord-005453-4057qib7 4441 13 sibling sibling NN cord-005453-4057qib7 4441 14 donor donor NN cord-005453-4057qib7 4441 15 transplant transplant NN cord-005453-4057qib7 4441 16 ( ( -LRB- cord-005453-4057qib7 4441 17 brother brother NN cord-005453-4057qib7 4441 18 , , , cord-005453-4057qib7 4441 19 12 12 CD cord-005453-4057qib7 4441 20 years year NNS cord-005453-4057qib7 4441 21 ) ) -RRB- cord-005453-4057qib7 4441 22 for for IN cord-005453-4057qib7 4441 23 acute acute JJ cord-005453-4057qib7 4441 24 myeloid myeloid JJ cord-005453-4057qib7 4441 25 leukemia leukemia NN cord-005453-4057qib7 4441 26 ( ( -LRB- cord-005453-4057qib7 4441 27 AML AML NNP cord-005453-4057qib7 4441 28 ) ) -RRB- cord-005453-4057qib7 4441 29 , , , cord-005453-4057qib7 4441 30 with with IN cord-005453-4057qib7 4441 31 t(8;21 t(8;21 NNP cord-005453-4057qib7 4441 32 ) ) -RRB- cord-005453-4057qib7 4442 1 CR1,MRD CR1,MRD NNP cord-005453-4057qib7 4442 2 positive positive JJ cord-005453-4057qib7 4442 3 ( ( -LRB- cord-005453-4057qib7 4442 4 RUNX1-RUNX1T1 runx1-runx1t1 NN cord-005453-4057qib7 4442 5 ) ) -RRB- cord-005453-4057qib7 4442 6 . . . cord-005453-4057qib7 4443 1 The the DT cord-005453-4057qib7 4443 2 donor donor NN cord-005453-4057qib7 4443 3 was be VBD cord-005453-4057qib7 4443 4 blood blood NN cord-005453-4057qib7 4443 5 type type NN cord-005453-4057qib7 4443 6 A a DT cord-005453-4057qib7 4443 7 Rh Rh NNP cord-005453-4057qib7 4443 8 positive positive JJ cord-005453-4057qib7 4443 9 and and CC cord-005453-4057qib7 4443 10 the the DT cord-005453-4057qib7 4443 11 patient patient NN cord-005453-4057qib7 4443 12 0 0 CD cord-005453-4057qib7 4443 13 Rh Rh NNP cord-005453-4057qib7 4443 14 positive positive JJ cord-005453-4057qib7 4443 15 . . . cord-005453-4057qib7 4444 1 The the DT cord-005453-4057qib7 4444 2 patient patient NN cord-005453-4057qib7 4444 3 had have VBD cord-005453-4057qib7 4444 4 no no DT cord-005453-4057qib7 4444 5 complication complication NN cord-005453-4057qib7 4444 6 after after IN cord-005453-4057qib7 4444 7 transplant transplant NN cord-005453-4057qib7 4444 8 . . . cord-005453-4057qib7 4445 1 The the DT cord-005453-4057qib7 4445 2 day day NN cord-005453-4057qib7 4445 3 +30 +30 CD cord-005453-4057qib7 4445 4 bone bone NN cord-005453-4057qib7 4445 5 marrow marrow NN cord-005453-4057qib7 4445 6 puncture puncture NN cord-005453-4057qib7 4445 7 has have VBZ cord-005453-4057qib7 4445 8 shown show VBN cord-005453-4057qib7 4445 9 only only RB cord-005453-4057qib7 4445 10 few few JJ cord-005453-4057qib7 4445 11 erythroid erythroid JJ cord-005453-4057qib7 4445 12 precursors precursor NNS cord-005453-4057qib7 4445 13 and and CC cord-005453-4057qib7 4445 14 day day NN cord-005453-4057qib7 4445 15 +100 +100 . cord-005453-4057qib7 4446 1 puncture puncture NN cord-005453-4057qib7 4446 2 and and CC cord-005453-4057qib7 4446 3 biopsy biopsy JJ cord-005453-4057qib7 4446 4 no no DT cord-005453-4057qib7 4446 5 erythroid erythroid JJ cord-005453-4057qib7 4446 6 precursors precursor NNS cord-005453-4057qib7 4446 7 , , , cord-005453-4057qib7 4446 8 he -PRON- PRP cord-005453-4057qib7 4446 9 had have VBD cord-005453-4057qib7 4446 10 transfusion transfusion NN cord-005453-4057qib7 4446 11 dependent dependent JJ cord-005453-4057qib7 4446 12 anemia anemia NN cord-005453-4057qib7 4446 13 requiring require VBG cord-005453-4057qib7 4446 14 a a DT cord-005453-4057qib7 4446 15 RBC RBC NNP cord-005453-4057qib7 4446 16 transfusion transfusion NN cord-005453-4057qib7 4446 17 every every DT cord-005453-4057qib7 4446 18 two two CD cord-005453-4057qib7 4446 19 weeks week NNS cord-005453-4057qib7 4446 20 and and CC cord-005453-4057qib7 4446 21 retukulocytopenia retukulocytopenia NNP cord-005453-4057qib7 4446 22 . . . cord-005453-4057qib7 4447 1 Parvo parvo NN cord-005453-4057qib7 4447 2 virus virus NN cord-005453-4057qib7 4447 3 and and CC cord-005453-4057qib7 4447 4 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 4447 5 were be VBD cord-005453-4057qib7 4447 6 negative negative JJ cord-005453-4057qib7 4447 7 . . . cord-005453-4057qib7 4448 1 Due due IN cord-005453-4057qib7 4448 2 to to IN cord-005453-4057qib7 4448 3 very very RB cord-005453-4057qib7 4448 4 high high JJ cord-005453-4057qib7 4448 5 ferritin ferritin NN cord-005453-4057qib7 4448 6 level level NN cord-005453-4057qib7 4448 7 ( ( -LRB- cord-005453-4057qib7 4448 8 > > NFP cord-005453-4057qib7 4448 9 4.000u 4.000u NNP cord-005453-4057qib7 4448 10 / / SYM cord-005453-4057qib7 4448 11 l l NN cord-005453-4057qib7 4448 12 ) ) -RRB- cord-005453-4057qib7 4448 13 and and CC cord-005453-4057qib7 4448 14 increased increase VBN cord-005453-4057qib7 4448 15 luiver luiver NNP cord-005453-4057qib7 4448 16 enzymes enzyme NNS cord-005453-4057qib7 4448 17 without without IN cord-005453-4057qib7 4448 18 signs sign NNS cord-005453-4057qib7 4448 19 of of IN cord-005453-4057qib7 4448 20 GvHD GvHD NNP cord-005453-4057qib7 4448 21 , , , cord-005453-4057qib7 4448 22 the the DT cord-005453-4057qib7 4448 23 treatment treatment NN cord-005453-4057qib7 4448 24 with with IN cord-005453-4057qib7 4448 25 deferasirox deferasirox NNP cord-005453-4057qib7 4448 26 has have VBZ cord-005453-4057qib7 4448 27 been be VBN cord-005453-4057qib7 4448 28 started start VBN cord-005453-4057qib7 4448 29 . . . cord-005453-4057qib7 4449 1 The the DT cord-005453-4057qib7 4449 2 patient patient NN cord-005453-4057qib7 4449 3 has have VBZ cord-005453-4057qib7 4449 4 achived achive VBN cord-005453-4057qib7 4449 5 CR1 CR1 NNP cord-005453-4057qib7 4449 6 , , , cord-005453-4057qib7 4449 7 MRD MRD NNP cord-005453-4057qib7 4449 8 negative negative JJ cord-005453-4057qib7 4449 9 , , , cord-005453-4057qib7 4449 10 and and CC cord-005453-4057qib7 4449 11 has have VBZ cord-005453-4057qib7 4449 12 evidence evidence NN cord-005453-4057qib7 4449 13 of of IN cord-005453-4057qib7 4449 14 complete complete JJ cord-005453-4057qib7 4449 15 chimerism chimerism NN cord-005453-4057qib7 4449 16 . . . cord-005453-4057qib7 4450 1 High high JJ cord-005453-4057qib7 4450 2 titers titer NNS cord-005453-4057qib7 4450 3 of of IN cord-005453-4057qib7 4450 4 anti anti JJ cord-005453-4057qib7 4450 5 - - JJ cord-005453-4057qib7 4450 6 A a JJ cord-005453-4057qib7 4450 7 and and CC cord-005453-4057qib7 4450 8 anti anti JJ cord-005453-4057qib7 4450 9 - - JJ cord-005453-4057qib7 4450 10 B b NN cord-005453-4057qib7 4450 11 issohemagglutinin issohemagglutinin NN cord-005453-4057qib7 4450 12 was be VBD cord-005453-4057qib7 4450 13 present present JJ cord-005453-4057qib7 4450 14 . . . cord-005453-4057qib7 4451 1 We -PRON- PRP cord-005453-4057qib7 4451 2 started start VBD cord-005453-4057qib7 4451 3 the the DT cord-005453-4057qib7 4451 4 treatment treatment NN cord-005453-4057qib7 4451 5 with with IN cord-005453-4057qib7 4451 6 Rituximab Rituximab NNP cord-005453-4057qib7 4451 7 375mg 375mg NNP cord-005453-4057qib7 4451 8 / / SYM cord-005453-4057qib7 4451 9 m2 m2 NNP cord-005453-4057qib7 4451 10 weekly weekly NN cord-005453-4057qib7 4451 11 , , , cord-005453-4057qib7 4451 12 4 4 CD cord-005453-4057qib7 4451 13 weeks week NNS cord-005453-4057qib7 4451 14 , , , cord-005453-4057qib7 4451 15 however however RB cord-005453-4057qib7 4451 16 without without IN cord-005453-4057qib7 4451 17 response response NN cord-005453-4057qib7 4451 18 . . . cord-005453-4057qib7 4452 1 The the DT cord-005453-4057qib7 4452 2 pathogenesis pathogenesis NN cord-005453-4057qib7 4452 3 of of IN cord-005453-4057qib7 4452 4 the the DT cord-005453-4057qib7 4452 5 PRCA PRCA NNP cord-005453-4057qib7 4452 6 is be VBZ cord-005453-4057qib7 4452 7 thought think VBN cord-005453-4057qib7 4452 8 to to TO cord-005453-4057qib7 4452 9 be be VB cord-005453-4057qib7 4452 10 due due JJ cord-005453-4057qib7 4452 11 to to IN cord-005453-4057qib7 4452 12 the the DT cord-005453-4057qib7 4452 13 recipients recipient NNS cord-005453-4057qib7 4452 14 plasma plasma NN cord-005453-4057qib7 4452 15 cells cell NNS cord-005453-4057qib7 4452 16 , , , cord-005453-4057qib7 4452 17 bortezomib bortezomib NNP cord-005453-4057qib7 4452 18 , , , cord-005453-4057qib7 4452 19 a a DT cord-005453-4057qib7 4452 20 proteasome proteasome VBN cord-005453-4057qib7 4452 21 inhibitor inhibitor NN cord-005453-4057qib7 4452 22 inducing induce VBG cord-005453-4057qib7 4452 23 apoptosis apoptosis NN cord-005453-4057qib7 4452 24 of of IN cord-005453-4057qib7 4452 25 plasma plasma NN cord-005453-4057qib7 4452 26 cells cell NNS cord-005453-4057qib7 4452 27 has have VBZ cord-005453-4057qib7 4452 28 been be VBN cord-005453-4057qib7 4452 29 given give VBN cord-005453-4057qib7 4452 30 s. s. NNP cord-005453-4057qib7 4452 31 c. c. NNP cord-005453-4057qib7 4452 32 1,3mg 1,3mg NNP cord-005453-4057qib7 4452 33 / / SYM cord-005453-4057qib7 4452 34 m2 m2 NNP cord-005453-4057qib7 4452 35 two two CD cord-005453-4057qib7 4452 36 times time NNS cord-005453-4057qib7 4452 37 weekly weekly RB cord-005453-4057qib7 4452 38 , , , cord-005453-4057qib7 4452 39 for for IN cord-005453-4057qib7 4452 40 two two CD cord-005453-4057qib7 4452 41 weeks week NNS cord-005453-4057qib7 4452 42 . . . cord-005453-4057qib7 4453 1 The the DT cord-005453-4057qib7 4453 2 patient patient NN cord-005453-4057qib7 4453 3 responded respond VBD cord-005453-4057qib7 4453 4 to to IN cord-005453-4057qib7 4453 5 the the DT cord-005453-4057qib7 4453 6 treatment treatment NN cord-005453-4057qib7 4453 7 two two CD cord-005453-4057qib7 4453 8 weeks week NNS cord-005453-4057qib7 4453 9 later later RB cord-005453-4057qib7 4453 10 with with IN cord-005453-4057qib7 4453 11 increase increase NN cord-005453-4057qib7 4453 12 in in IN cord-005453-4057qib7 4453 13 Hb Hb NNP cord-005453-4057qib7 4453 14 , , , cord-005453-4057qib7 4453 15 which which WDT cord-005453-4057qib7 4453 16 was be VBD cord-005453-4057qib7 4453 17 12,9 12,9 CD cord-005453-4057qib7 4453 18 g g NNP cord-005453-4057qib7 4453 19 / / SYM cord-005453-4057qib7 4453 20 dl dl NN cord-005453-4057qib7 4453 21 and and CC cord-005453-4057qib7 4453 22 increase increase VB cord-005453-4057qib7 4453 23 in in IN cord-005453-4057qib7 4453 24 retikulocyte retikulocyte JJ cord-005453-4057qib7 4453 25 number number NN cord-005453-4057qib7 4453 26 . . . cord-005453-4057qib7 4454 1 The the DT cord-005453-4057qib7 4454 2 patient patient NN cord-005453-4057qib7 4454 3 has have VBZ cord-005453-4057qib7 4454 4 continued continue VBN cord-005453-4057qib7 4454 5 to to TO cord-005453-4057qib7 4454 6 be be VB cord-005453-4057qib7 4454 7 well well RB cord-005453-4057qib7 4454 8 at at IN cord-005453-4057qib7 4454 9 the the DT cord-005453-4057qib7 4454 10 last last JJ cord-005453-4057qib7 4454 11 control control NN cord-005453-4057qib7 4454 12 . . . cord-005453-4057qib7 4455 1 Conclusions conclusion NNS cord-005453-4057qib7 4455 2 : : : cord-005453-4057qib7 4456 1 PRCA PRCA NNP cord-005453-4057qib7 4456 2 aplasia aplasia NNP cord-005453-4057qib7 4456 3 is be VBZ cord-005453-4057qib7 4456 4 a a DT cord-005453-4057qib7 4456 5 rare rare JJ cord-005453-4057qib7 4456 6 but but CC cord-005453-4057qib7 4456 7 serious serious JJ cord-005453-4057qib7 4456 8 complication complication NN cord-005453-4057qib7 4456 9 after after IN cord-005453-4057qib7 4456 10 ABO ABO NNP cord-005453-4057qib7 4456 11 - - HYPH cord-005453-4057qib7 4456 12 incompatible incompatible JJ cord-005453-4057qib7 4456 13 HCT hct NN cord-005453-4057qib7 4456 14 . . . cord-005453-4057qib7 4457 1 Bortezomib Bortezomib NNP cord-005453-4057qib7 4457 2 is be VBZ cord-005453-4057qib7 4457 3 an an DT cord-005453-4057qib7 4457 4 effective effective JJ cord-005453-4057qib7 4457 5 treatment treatment NN cord-005453-4057qib7 4457 6 for for IN cord-005453-4057qib7 4457 7 this this DT cord-005453-4057qib7 4457 8 complication complication NN cord-005453-4057qib7 4457 9 if if IN cord-005453-4057qib7 4457 10 mediated mediate VBN cord-005453-4057qib7 4457 11 by by IN cord-005453-4057qib7 4457 12 residual residual JJ cord-005453-4057qib7 4457 13 host host NN cord-005453-4057qib7 4457 14 isohemeagglutinins isohemeagglutinin NNS cord-005453-4057qib7 4457 15 after after IN cord-005453-4057qib7 4457 16 HCT HCT NNP cord-005453-4057qib7 4457 17 and and CC cord-005453-4057qib7 4457 18 should should MD cord-005453-4057qib7 4457 19 be be VB cord-005453-4057qib7 4457 20 recommended recommend VBN cord-005453-4057qib7 4457 21 as as IN cord-005453-4057qib7 4457 22 standard standard NN cord-005453-4057qib7 4457 23 of of IN cord-005453-4057qib7 4457 24 care care NN cord-005453-4057qib7 4457 25 . . . cord-005453-4057qib7 4458 1 Clinical clinical JJ cord-005453-4057qib7 4458 2 Methods method NNS cord-005453-4057qib7 4459 1 : : : cord-005453-4057qib7 4459 2 This this DT cord-005453-4057qib7 4459 3 work work NN cord-005453-4057qib7 4459 4 is be VBZ cord-005453-4057qib7 4459 5 retrospective retrospective JJ cord-005453-4057qib7 4459 6 , , , cord-005453-4057qib7 4459 7 observational observational JJ cord-005453-4057qib7 4459 8 , , , cord-005453-4057qib7 4459 9 cross cross JJ cord-005453-4057qib7 4459 10 - - JJ cord-005453-4057qib7 4459 11 sectional sectional JJ cord-005453-4057qib7 4459 12 and and CC cord-005453-4057qib7 4459 13 analytical analytical JJ cord-005453-4057qib7 4459 14 . . . cord-005453-4057qib7 4460 1 It -PRON- PRP cord-005453-4057qib7 4460 2 included include VBD cord-005453-4057qib7 4460 3 all all DT cord-005453-4057qib7 4460 4 patients patient NNS cord-005453-4057qib7 4460 5 who who WP cord-005453-4057qib7 4460 6 received receive VBD cord-005453-4057qib7 4460 7 HSCT HSCT NNP cord-005453-4057qib7 4460 8 at at IN cord-005453-4057qib7 4460 9 Stem Stem NNP cord-005453-4057qib7 4460 10 Cell Cell NNP cord-005453-4057qib7 4460 11 Transplantation Transplantation NNP cord-005453-4057qib7 4460 12 Unit unit NN cord-005453-4057qib7 4460 13 ( ( -LRB- cord-005453-4057qib7 4460 14 UTMO UTMO NNP cord-005453-4057qib7 4460 15 , , , cord-005453-4057qib7 4460 16 by by IN cord-005453-4057qib7 4460 17 its -PRON- PRP$ cord-005453-4057qib7 4460 18 Spanish spanish JJ cord-005453-4057qib7 4460 19 acronym acronym NN cord-005453-4057qib7 4460 20 ) ) -RRB- cord-005453-4057qib7 4460 21 at at IN cord-005453-4057qib7 4460 22 SOLCA SOLCA NNP cord-005453-4057qib7 4460 23 - - HYPH cord-005453-4057qib7 4460 24 Guayaquil Guayaquil NNP cord-005453-4057qib7 4460 25 , , , cord-005453-4057qib7 4460 26 between between IN cord-005453-4057qib7 4460 27 the the DT cord-005453-4057qib7 4460 28 years year NNS cord-005453-4057qib7 4460 29 2009 2009 CD cord-005453-4057qib7 4460 30 -2016.We -2016.We JJS cord-005453-4057qib7 4460 31 use use VBP cord-005453-4057qib7 4460 32 the the DT cord-005453-4057qib7 4460 33 Kaplan Kaplan NNP cord-005453-4057qib7 4460 34 - - HYPH cord-005453-4057qib7 4460 35 Meier Meier NNP cord-005453-4057qib7 4460 36 method method NN cord-005453-4057qib7 4460 37 to to TO cord-005453-4057qib7 4460 38 analyze analyze VB cord-005453-4057qib7 4460 39 the the DT cord-005453-4057qib7 4460 40 survival survival NN cord-005453-4057qib7 4460 41 rate rate NN cord-005453-4057qib7 4460 42 between between IN cord-005453-4057qib7 4460 43 the the DT cord-005453-4057qib7 4460 44 autologous autologous JJ cord-005453-4057qib7 4460 45 and and CC cord-005453-4057qib7 4460 46 allogeneic allogeneic NN cord-005453-4057qib7 4460 47 transplant transplant NN cord-005453-4057qib7 4460 48 . . . cord-005453-4057qib7 4461 1 The the DT cord-005453-4057qib7 4461 2 information information NN cord-005453-4057qib7 4461 3 collected collect VBN cord-005453-4057qib7 4461 4 for for IN cord-005453-4057qib7 4461 5 this this DT cord-005453-4057qib7 4461 6 study study NN cord-005453-4057qib7 4461 7 was be VBD cord-005453-4057qib7 4461 8 obtained obtain VBN cord-005453-4057qib7 4461 9 from from IN cord-005453-4057qib7 4461 10 the the DT cord-005453-4057qib7 4461 11 database database NN cord-005453-4057qib7 4461 12 of of IN cord-005453-4057qib7 4461 13 the the DT cord-005453-4057qib7 4461 14 SOLCAy SOLCAy NNPS cord-005453-4057qib7 4461 15 Institute Institute NNP cord-005453-4057qib7 4461 16 and and CC cord-005453-4057qib7 4461 17 the the DT cord-005453-4057qib7 4461 18 review review NN cord-005453-4057qib7 4461 19 of of IN cord-005453-4057qib7 4461 20 the the DT cord-005453-4057qib7 4461 21 files file NNS cord-005453-4057qib7 4461 22 of of IN cord-005453-4057qib7 4461 23 the the DT cord-005453-4057qib7 4461 24 patients patient NNS cord-005453-4057qib7 4461 25 included include VBN cord-005453-4057qib7 4461 26 . . . cord-005453-4057qib7 4462 1 Results result NNS cord-005453-4057qib7 4462 2 : : : cord-005453-4057qib7 4463 1 At at RB cord-005453-4057qib7 4463 2 least least JJS cord-005453-4057qib7 4463 3 , , , cord-005453-4057qib7 4463 4 150 150 CD cord-005453-4057qib7 4463 5 patients patient NNS cord-005453-4057qib7 4463 6 have have VBP cord-005453-4057qib7 4463 7 been be VBN cord-005453-4057qib7 4463 8 undergoing undergo VBG cord-005453-4057qib7 4463 9 to to IN cord-005453-4057qib7 4463 10 HSCT HSCT NNP cord-005453-4057qib7 4463 11 between between IN cord-005453-4057qib7 4463 12 2009 2009 CD cord-005453-4057qib7 4463 13 - - SYM cord-005453-4057qib7 4463 14 2016 2016 CD cord-005453-4057qib7 4463 15 years year NNS cord-005453-4057qib7 4463 16 . . . cord-005453-4057qib7 4464 1 According accord VBG cord-005453-4057qib7 4464 2 to to IN cord-005453-4057qib7 4464 3 the the DT cord-005453-4057qib7 4464 4 type type NN cord-005453-4057qib7 4464 5 of of IN cord-005453-4057qib7 4464 6 HSCT HSCT NNP cord-005453-4057qib7 4464 7 , , , cord-005453-4057qib7 4464 8 42.1 42.1 CD cord-005453-4057qib7 4464 9 % % NN cord-005453-4057qib7 4464 10 received receive VBD cord-005453-4057qib7 4464 11 an an DT cord-005453-4057qib7 4464 12 autologous autologous JJ cord-005453-4057qib7 4464 13 transplant transplant NN cord-005453-4057qib7 4464 14 and and CC cord-005453-4057qib7 4464 15 57.9 57.9 CD cord-005453-4057qib7 4464 16 % % NN cord-005453-4057qib7 4464 17 received receive VBD cord-005453-4057qib7 4464 18 an an DT cord-005453-4057qib7 4464 19 allogeneic allogeneic NN cord-005453-4057qib7 4464 20 transplant transplant NN cord-005453-4057qib7 4464 21 , , , cord-005453-4057qib7 4464 22 from from IN cord-005453-4057qib7 4464 23 which which WDT cord-005453-4057qib7 4464 24 79.3 79.3 CD cord-005453-4057qib7 4464 25 % % NN cord-005453-4057qib7 4464 26 were be VBD cord-005453-4057qib7 4464 27 from from IN cord-005453-4057qib7 4464 28 a a DT cord-005453-4057qib7 4464 29 related related JJ cord-005453-4057qib7 4464 30 donor donor NN cord-005453-4057qib7 4464 31 . . . cord-005453-4057qib7 4465 1 The the DT cord-005453-4057qib7 4465 2 main main JJ cord-005453-4057qib7 4465 3 source source NN cord-005453-4057qib7 4465 4 of of IN cord-005453-4057qib7 4465 5 transplant transplant NN cord-005453-4057qib7 4465 6 was be VBD cord-005453-4057qib7 4465 7 peripheral peripheral JJ cord-005453-4057qib7 4465 8 blood blood NN cord-005453-4057qib7 4465 9 in in IN cord-005453-4057qib7 4465 10 86.67 86.67 CD cord-005453-4057qib7 4465 11 % % NN cord-005453-4057qib7 4465 12 , , , cord-005453-4057qib7 4465 13 followed follow VBN cord-005453-4057qib7 4465 14 by by IN cord-005453-4057qib7 4465 15 12 12 CD cord-005453-4057qib7 4465 16 % % NN cord-005453-4057qib7 4465 17 obtained obtain VBN cord-005453-4057qib7 4465 18 from from IN cord-005453-4057qib7 4465 19 umbilical umbilical JJ cord-005453-4057qib7 4465 20 cord cord NN cord-005453-4057qib7 4465 21 blood blood NN cord-005453-4057qib7 4465 22 and and CC cord-005453-4057qib7 4465 23 1.33 1.33 CD cord-005453-4057qib7 4465 24 % % NN cord-005453-4057qib7 4465 25 by by IN cord-005453-4057qib7 4465 26 bone bone NN cord-005453-4057qib7 4465 27 marrow marrow NN cord-005453-4057qib7 4465 28 aspiration aspiration NN cord-005453-4057qib7 4465 29 . . . cord-005453-4057qib7 4466 1 The the DT cord-005453-4057qib7 4466 2 most most RBS cord-005453-4057qib7 4466 3 frequently frequently RB cord-005453-4057qib7 4466 4 reported report VBN cord-005453-4057qib7 4466 5 pathologies pathology NNS cord-005453-4057qib7 4466 6 were be VBD cord-005453-4057qib7 4466 7 acute acute JJ cord-005453-4057qib7 4466 8 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 4466 9 leukemia leukemia NN cord-005453-4057qib7 4466 10 ( ( -LRB- cord-005453-4057qib7 4466 11 ALL all DT cord-005453-4057qib7 4466 12 ) ) -RRB- cord-005453-4057qib7 4466 13 ( ( -LRB- cord-005453-4057qib7 4466 14 34 34 CD cord-005453-4057qib7 4466 15 % % NN cord-005453-4057qib7 4466 16 ) ) -RRB- cord-005453-4057qib7 4466 17 , , , cord-005453-4057qib7 4466 18 multiple multiple JJ cord-005453-4057qib7 4466 19 myeloma myeloma NN cord-005453-4057qib7 4466 20 ( ( -LRB- cord-005453-4057qib7 4466 21 MM MM NNP cord-005453-4057qib7 4466 22 ) ) -RRB- cord-005453-4057qib7 4466 23 ( ( -LRB- cord-005453-4057qib7 4466 24 22 22 CD cord-005453-4057qib7 4466 25 % % NN cord-005453-4057qib7 4466 26 ) ) -RRB- cord-005453-4057qib7 4466 27 and and CC cord-005453-4057qib7 4466 28 acute acute JJ cord-005453-4057qib7 4466 29 myeloid myeloid NN cord-005453-4057qib7 4466 30 leukemia leukemia NN cord-005453-4057qib7 4466 31 ( ( -LRB- cord-005453-4057qib7 4466 32 AML AML NNP cord-005453-4057qib7 4466 33 ) ) -RRB- cord-005453-4057qib7 4466 34 ( ( -LRB- cord-005453-4057qib7 4466 35 13.33 13.33 CD cord-005453-4057qib7 4466 36 % % NN cord-005453-4057qib7 4466 37 ) ) -RRB- cord-005453-4057qib7 4466 38 . . . cord-005453-4057qib7 4467 1 The the DT cord-005453-4057qib7 4467 2 overall overall JJ cord-005453-4057qib7 4467 3 survival survival NN cord-005453-4057qib7 4467 4 was be VBD cord-005453-4057qib7 4467 5 68 68 CD cord-005453-4057qib7 4467 6 % % NN cord-005453-4057qib7 4467 7 ( ( -LRB- cord-005453-4057qib7 4467 8 IC IC NNP cord-005453-4057qib7 4467 9 : : : cord-005453-4057qib7 4467 10 95 95 CD cord-005453-4057qib7 4467 11 % % NN cord-005453-4057qib7 4467 12 ) ) -RRB- cord-005453-4057qib7 4467 13 . . . cord-005453-4057qib7 4468 1 The the DT cord-005453-4057qib7 4468 2 82.53 82.53 CD cord-005453-4057qib7 4468 3 % % NN cord-005453-4057qib7 4468 4 of of IN cord-005453-4057qib7 4468 5 patients patient NNS cord-005453-4057qib7 4468 6 that that WDT cord-005453-4057qib7 4468 7 were be VBD cord-005453-4057qib7 4468 8 undergoing undergo VBG cord-005453-4057qib7 4468 9 to to IN cord-005453-4057qib7 4468 10 autologous autologous JJ cord-005453-4057qib7 4468 11 transplant transplant NN cord-005453-4057qib7 4468 12 have have VBP cord-005453-4057qib7 4468 13 survive survive VB cord-005453-4057qib7 4468 14 , , , cord-005453-4057qib7 4468 15 meanwhile meanwhile RB cord-005453-4057qib7 4468 16 the the DT cord-005453-4057qib7 4468 17 patients patient NNS cord-005453-4057qib7 4468 18 that that WDT cord-005453-4057qib7 4468 19 were be VBD cord-005453-4057qib7 4468 20 undergoing undergo VBG cord-005453-4057qib7 4468 21 allogeneic allogeneic NN cord-005453-4057qib7 4468 22 transplant transplant NN cord-005453-4057qib7 4468 23 only only RB cord-005453-4057qib7 4468 24 the the DT cord-005453-4057qib7 4468 25 57.47 57.47 CD cord-005453-4057qib7 4468 26 % % NN cord-005453-4057qib7 4468 27 have have VBP cord-005453-4057qib7 4468 28 survived survive VBN cord-005453-4057qib7 4468 29 ( ( -LRB- cord-005453-4057qib7 4468 30 p p NN cord-005453-4057qib7 4468 31 < < XX cord-005453-4057qib7 4468 32 0.05 0.05 CD cord-005453-4057qib7 4468 33 ) ) -RRB- cord-005453-4057qib7 4468 34 . . . cord-005453-4057qib7 4469 1 The the DT cord-005453-4057qib7 4469 2 highest high JJS cord-005453-4057qib7 4469 3 death death NN cord-005453-4057qib7 4469 4 rate rate NN cord-005453-4057qib7 4469 5 occurred occur VBD cord-005453-4057qib7 4469 6 during during IN cord-005453-4057qib7 4469 7 the the DT cord-005453-4057qib7 4469 8 first first JJ cord-005453-4057qib7 4469 9 year year NN cord-005453-4057qib7 4469 10 after after IN cord-005453-4057qib7 4469 11 HSCT HSCT NNP cord-005453-4057qib7 4469 12 , , , cord-005453-4057qib7 4469 13 and and CC cord-005453-4057qib7 4469 14 decreased decrease VBD cord-005453-4057qib7 4469 15 considerably considerably RB cord-005453-4057qib7 4469 16 after after IN cord-005453-4057qib7 4469 17 that that DT cord-005453-4057qib7 4469 18 period period NN cord-005453-4057qib7 4469 19 . . . cord-005453-4057qib7 4470 1 The the DT cord-005453-4057qib7 4470 2 main main JJ cord-005453-4057qib7 4470 3 cause cause NN cord-005453-4057qib7 4470 4 of of IN cord-005453-4057qib7 4470 5 mortality mortality NN cord-005453-4057qib7 4470 6 related relate VBN cord-005453-4057qib7 4470 7 to to IN cord-005453-4057qib7 4470 8 transplant transplant NN cord-005453-4057qib7 4470 9 ( ( -LRB- cord-005453-4057qib7 4470 10 MRT MRT NNP cord-005453-4057qib7 4470 11 ) ) -RRB- cord-005453-4057qib7 4470 12 was be VBD cord-005453-4057qib7 4470 13 the the DT cord-005453-4057qib7 4470 14 graft graft NN cord-005453-4057qib7 4470 15 - - HYPH cord-005453-4057qib7 4470 16 versus versus IN cord-005453-4057qib7 4470 17 - - HYPH cord-005453-4057qib7 4470 18 host host NN cord-005453-4057qib7 4470 19 disease disease NN cord-005453-4057qib7 4470 20 ( ( -LRB- cord-005453-4057qib7 4470 21 GVHD GVHD NNP cord-005453-4057qib7 4470 22 ) ) -RRB- cord-005453-4057qib7 4470 23 ( ( -LRB- cord-005453-4057qib7 4470 24 8 8 CD cord-005453-4057qib7 4470 25 % % NN cord-005453-4057qib7 4470 26 ) ) -RRB- cord-005453-4057qib7 4470 27 ; ; : cord-005453-4057qib7 4470 28 however however RB cord-005453-4057qib7 4470 29 , , , cord-005453-4057qib7 4470 30 the the DT cord-005453-4057qib7 4470 31 main main JJ cord-005453-4057qib7 4470 32 cause cause NN cord-005453-4057qib7 4470 33 of of IN cord-005453-4057qib7 4470 34 mortality mortality NN cord-005453-4057qib7 4470 35 in in IN cord-005453-4057qib7 4470 36 the the DT cord-005453-4057qib7 4470 37 study study NN cord-005453-4057qib7 4470 38 population population NN cord-005453-4057qib7 4470 39 ( ( -LRB- cord-005453-4057qib7 4470 40 n=150 n=150 NNP cord-005453-4057qib7 4470 41 ) ) -RRB- cord-005453-4057qib7 4470 42 was be VBD cord-005453-4057qib7 4470 43 relapse relapse NN cord-005453-4057qib7 4470 44 in in IN cord-005453-4057qib7 4470 45 12.66 12.66 CD cord-005453-4057qib7 4470 46 % % NN cord-005453-4057qib7 4470 47 of of IN cord-005453-4057qib7 4470 48 the the DT cord-005453-4057qib7 4470 49 patients patient NNS cord-005453-4057qib7 4470 50 , , , cord-005453-4057qib7 4470 51 presented present VBD cord-005453-4057qib7 4470 52 more more RBR cord-005453-4057qib7 4470 53 frequently frequently RB cord-005453-4057qib7 4470 54 in in IN cord-005453-4057qib7 4470 55 ALL all DT cord-005453-4057qib7 4470 56 . . . cord-005453-4057qib7 4471 1 Conclusions conclusion NNS cord-005453-4057qib7 4471 2 : : : cord-005453-4057qib7 4472 1 The the DT cord-005453-4057qib7 4472 2 results result NNS cord-005453-4057qib7 4472 3 showed show VBD cord-005453-4057qib7 4472 4 that that IN cord-005453-4057qib7 4472 5 68 68 CD cord-005453-4057qib7 4472 6 % % NN cord-005453-4057qib7 4472 7 of of IN cord-005453-4057qib7 4472 8 patients patient NNS cord-005453-4057qib7 4472 9 undergoing undergo VBG cord-005453-4057qib7 4472 10 to to IN cord-005453-4057qib7 4472 11 HSCT HSCT NNP cord-005453-4057qib7 4472 12 have have VBP cord-005453-4057qib7 4472 13 survived survive VBN cord-005453-4057qib7 4472 14 . . . cord-005453-4057qib7 4473 1 A a DT cord-005453-4057qib7 4473 2 high high JJ cord-005453-4057qib7 4473 3 rate rate NN cord-005453-4057qib7 4473 4 of of IN cord-005453-4057qib7 4473 5 deceased deceased JJ cord-005453-4057qib7 4473 6 patients patient NNS cord-005453-4057qib7 4473 7 in in IN cord-005453-4057qib7 4473 8 this this DT cord-005453-4057qib7 4473 9 study study NN cord-005453-4057qib7 4473 10 , , , cord-005453-4057qib7 4473 11 have have VBP cord-005453-4057qib7 4473 12 died die VBN cord-005453-4057qib7 4473 13 in in IN cord-005453-4057qib7 4473 14 the the DT cord-005453-4057qib7 4473 15 first first JJ cord-005453-4057qib7 4473 16 year year NN cord-005453-4057qib7 4473 17 before before IN cord-005453-4057qib7 4473 18 the the DT cord-005453-4057qib7 4473 19 transplant transplant NN cord-005453-4057qib7 4473 20 ( ( -LRB- cord-005453-4057qib7 4473 21 26.6 26.6 CD cord-005453-4057qib7 4473 22 % % NN cord-005453-4057qib7 4473 23 % % NN cord-005453-4057qib7 4473 24 ) ) -RRB- cord-005453-4057qib7 4473 25 , , , cord-005453-4057qib7 4473 26 due due IN cord-005453-4057qib7 4473 27 to to IN cord-005453-4057qib7 4473 28 relapse relapse NN cord-005453-4057qib7 4473 29 . . . cord-005453-4057qib7 4474 1 The the DT cord-005453-4057qib7 4474 2 main main JJ cord-005453-4057qib7 4474 3 cause cause NN cord-005453-4057qib7 4474 4 of of IN cord-005453-4057qib7 4474 5 deceased deceased JJ cord-005453-4057qib7 4474 6 in in IN cord-005453-4057qib7 4474 7 the the DT cord-005453-4057qib7 4474 8 study study NN cord-005453-4057qib7 4474 9 is be VBZ cord-005453-4057qib7 4474 10 not not RB cord-005453-4057qib7 4474 11 related relate VBN cord-005453-4057qib7 4474 12 to to IN cord-005453-4057qib7 4474 13 HSCT HSCT NNP cord-005453-4057qib7 4474 14 , , , cord-005453-4057qib7 4474 15 and and CC cord-005453-4057qib7 4474 16 was be VBD cord-005453-4057qib7 4474 17 the the DT cord-005453-4057qib7 4474 18 relapse relapse NN cord-005453-4057qib7 4474 19 in in IN cord-005453-4057qib7 4474 20 12 12 CD cord-005453-4057qib7 4474 21 % % NN cord-005453-4057qib7 4474 22 of of IN cord-005453-4057qib7 4474 23 patients patient NNS cord-005453-4057qib7 4474 24 , , , cord-005453-4057qib7 4474 25 in in IN cord-005453-4057qib7 4474 26 compare compare VB cord-005453-4057qib7 4474 27 the the DT cord-005453-4057qib7 4474 28 GVHD GVHD NNP cord-005453-4057qib7 4474 29 was be VBD cord-005453-4057qib7 4474 30 the the DT cord-005453-4057qib7 4474 31 main main JJ cord-005453-4057qib7 4474 32 cause cause NN cord-005453-4057qib7 4474 33 of of IN cord-005453-4057qib7 4474 34 MRT MRT NNP cord-005453-4057qib7 4474 35 ( ( -LRB- cord-005453-4057qib7 4474 36 8 8 CD cord-005453-4057qib7 4474 37 % % NN cord-005453-4057qib7 4474 38 ) ) -RRB- cord-005453-4057qib7 4474 39 . . . cord-005453-4057qib7 4475 1 We -PRON- PRP cord-005453-4057qib7 4475 2 consider consider VBP cord-005453-4057qib7 4475 3 that that IN cord-005453-4057qib7 4475 4 HSCT HSCT NNP cord-005453-4057qib7 4475 5 is be VBZ cord-005453-4057qib7 4475 6 a a DT cord-005453-4057qib7 4475 7 technique technique NN cord-005453-4057qib7 4475 8 that that WDT cord-005453-4057qib7 4475 9 is be VBZ cord-005453-4057qib7 4475 10 still still RB cord-005453-4057qib7 4475 11 under under IN cord-005453-4057qib7 4475 12 development development NN cord-005453-4057qib7 4475 13 in in IN cord-005453-4057qib7 4475 14 Ecuador Ecuador NNP cord-005453-4057qib7 4475 15 , , , cord-005453-4057qib7 4475 16 but but CC cord-005453-4057qib7 4475 17 despite despite IN cord-005453-4057qib7 4475 18 the the DT cord-005453-4057qib7 4475 19 short short JJ cord-005453-4057qib7 4475 20 time time NN cord-005453-4057qib7 4475 21 it -PRON- PRP cord-005453-4057qib7 4475 22 has have VBZ cord-005453-4057qib7 4475 23 been be VBN cord-005453-4057qib7 4475 24 taking take VBG cord-005453-4057qib7 4475 25 and and CC cord-005453-4057qib7 4475 26 the the DT cord-005453-4057qib7 4475 27 institutional institutional JJ cord-005453-4057qib7 4475 28 and and CC cord-005453-4057qib7 4475 29 medical medical JJ cord-005453-4057qib7 4475 30 limitations limitation NNS cord-005453-4057qib7 4475 31 present present JJ cord-005453-4057qib7 4475 32 in in IN cord-005453-4057qib7 4475 33 the the DT cord-005453-4057qib7 4475 34 health health NN cord-005453-4057qib7 4475 35 field field NN cord-005453-4057qib7 4475 36 , , , cord-005453-4057qib7 4475 37 has have VBZ cord-005453-4057qib7 4475 38 presented present VBN cord-005453-4057qib7 4475 39 excellent excellent JJ cord-005453-4057qib7 4475 40 results result NNS cord-005453-4057qib7 4475 41 comparable comparable JJ cord-005453-4057qib7 4475 42 to to IN cord-005453-4057qib7 4475 43 studies study NNS cord-005453-4057qib7 4475 44 conducted conduct VBN cord-005453-4057qib7 4475 45 in in IN cord-005453-4057qib7 4475 46 developed develop VBN cord-005453-4057qib7 4475 47 countries country NNS cord-005453-4057qib7 4475 48 . . . cord-005453-4057qib7 4476 1 [ [ -LRB- cord-005453-4057qib7 4476 2 Background background NN cord-005453-4057qib7 4476 3 : : : cord-005453-4057qib7 4476 4 Pigmented pigmented JJ cord-005453-4057qib7 4476 5 epithelioid epithelioid NN cord-005453-4057qib7 4476 6 melanocytoma melanocytoma NN cord-005453-4057qib7 4476 7 ( ( -LRB- cord-005453-4057qib7 4476 8 PEM PEM NNP cord-005453-4057qib7 4476 9 , , , cord-005453-4057qib7 4476 10 early early RB cord-005453-4057qib7 4476 11 known know VBN cord-005453-4057qib7 4476 12 as as IN cord-005453-4057qib7 4476 13 ' ' `` cord-005453-4057qib7 4476 14 Аnimal Аnimal NNP cord-005453-4057qib7 4476 15 type type NN cord-005453-4057qib7 4476 16 ' ' '' cord-005453-4057qib7 4476 17 melanoma melanoma NN cord-005453-4057qib7 4476 18 ) ) -RRB- cord-005453-4057qib7 4476 19 is be VBZ cord-005453-4057qib7 4476 20 a a DT cord-005453-4057qib7 4476 21 rare rare JJ cord-005453-4057qib7 4476 22 tumor tumor NN cord-005453-4057qib7 4476 23 with with IN cord-005453-4057qib7 4476 24 unpredictable unpredictable JJ cord-005453-4057qib7 4476 25 clinical clinical JJ cord-005453-4057qib7 4476 26 behavior behavior NN cord-005453-4057qib7 4476 27 and and CC cord-005453-4057qib7 4476 28 metastatic metastatic JJ cord-005453-4057qib7 4476 29 potential potential NN cord-005453-4057qib7 4476 30 . . . cord-005453-4057qib7 4477 1 PEM PEM NNP cord-005453-4057qib7 4477 2 generally generally RB cord-005453-4057qib7 4477 3 has have VBZ cord-005453-4057qib7 4477 4 favorable favorable JJ cord-005453-4057qib7 4477 5 prognosis prognosis NN cord-005453-4057qib7 4477 6 . . . cord-005453-4057qib7 4478 1 Involvement involvement NN cord-005453-4057qib7 4478 2 of of IN cord-005453-4057qib7 4478 3 regional regional JJ cord-005453-4057qib7 4478 4 lymph lymph NN cord-005453-4057qib7 4478 5 nodes node NNS cord-005453-4057qib7 4478 6 is be VBZ cord-005453-4057qib7 4478 7 not not RB cord-005453-4057qib7 4478 8 rare rare JJ cord-005453-4057qib7 4478 9 . . . cord-005453-4057qib7 4479 1 Extranodal extranodal JJ cord-005453-4057qib7 4479 2 and and CC cord-005453-4057qib7 4479 3 distant distant JJ cord-005453-4057qib7 4479 4 nodal nodal JJ cord-005453-4057qib7 4479 5 metastases metastasis NNS cord-005453-4057qib7 4479 6 are be VBP cord-005453-4057qib7 4479 7 extremely extremely RB cord-005453-4057qib7 4479 8 rare rare JJ cord-005453-4057qib7 4479 9 . . . cord-005453-4057qib7 4480 1 We -PRON- PRP cord-005453-4057qib7 4480 2 report report VBP cord-005453-4057qib7 4480 3 about about IN cord-005453-4057qib7 4480 4 patient patient NN cord-005453-4057qib7 4480 5 with with IN cord-005453-4057qib7 4480 6 Fanconi Fanconi NNP cord-005453-4057qib7 4480 7 anemia anemia NN cord-005453-4057qib7 4480 8 ( ( -LRB- cord-005453-4057qib7 4480 9 FA FA NNP cord-005453-4057qib7 4480 10 ) ) -RRB- cord-005453-4057qib7 4480 11 and and CC cord-005453-4057qib7 4480 12 PEM PEM NNP cord-005453-4057qib7 4480 13 with with IN cord-005453-4057qib7 4480 14 developed develop VBN cord-005453-4057qib7 4480 15 distant distant JJ cord-005453-4057qib7 4480 16 metastases metastasis NNS cord-005453-4057qib7 4480 17 in in IN cord-005453-4057qib7 4480 18 the the DT cord-005453-4057qib7 4480 19 early early JJ cord-005453-4057qib7 4480 20 term term NN cord-005453-4057qib7 4480 21 after after IN cord-005453-4057qib7 4480 22 allogeneic allogeneic JJ cord-005453-4057qib7 4480 23 hematopoietic hematopoietic JJ cord-005453-4057qib7 4480 24 stem stem NN cord-005453-4057qib7 4480 25 cell cell NN cord-005453-4057qib7 4480 26 transplantation transplantation NN cord-005453-4057qib7 4480 27 ( ( -LRB- cord-005453-4057qib7 4480 28 HSCT HSCT NNP cord-005453-4057qib7 4480 29 ) ) -RRB- cord-005453-4057qib7 4480 30 . . . cord-005453-4057qib7 4481 1 Methods method NNS cord-005453-4057qib7 4481 2 : : : cord-005453-4057qib7 4482 1 10-years 10-years CD cord-005453-4057qib7 4482 2 old old JJ cord-005453-4057qib7 4482 3 boy boy NN cord-005453-4057qib7 4482 4 with with IN cord-005453-4057qib7 4482 5 FA FA NNP cord-005453-4057qib7 4482 6 was be VBD cord-005453-4057qib7 4482 7 hospitalized hospitalize VBN cord-005453-4057qib7 4482 8 for for IN cord-005453-4057qib7 4482 9 HSCT HSCT NNP cord-005453-4057qib7 4482 10 . . . cord-005453-4057qib7 4483 1 The the DT cord-005453-4057qib7 4483 2 blue blue JJ cord-005453-4057qib7 4483 3 - - HYPH cord-005453-4057qib7 4483 4 black black JJ cord-005453-4057qib7 4483 5 painless painless JJ cord-005453-4057qib7 4483 6 nodulus nodulus NNP cord-005453-4057qib7 4483 7 15х15 15х15 CD cord-005453-4057qib7 4483 8 mm mm NNP cord-005453-4057qib7 4483 9 was be VBD cord-005453-4057qib7 4483 10 noted note VBN cord-005453-4057qib7 4483 11 on on IN cord-005453-4057qib7 4483 12 the the DT cord-005453-4057qib7 4483 13 left left JJ cord-005453-4057qib7 4483 14 cheek cheek NN cord-005453-4057qib7 4483 15 . . . cord-005453-4057qib7 4484 1 This this DT cord-005453-4057qib7 4484 2 lesion lesion NN cord-005453-4057qib7 4484 3 was be VBD cord-005453-4057qib7 4484 4 observed observe VBN cord-005453-4057qib7 4484 5 from from IN cord-005453-4057qib7 4484 6 early early JJ cord-005453-4057qib7 4484 7 childhood childhood NN cord-005453-4057qib7 4484 8 and and CC cord-005453-4057qib7 4484 9 during during IN cord-005453-4057qib7 4484 10 life life NN cord-005453-4057qib7 4484 11 only only RB cord-005453-4057qib7 4484 12 slightly slightly RB cord-005453-4057qib7 4484 13 increased increase VBD cord-005453-4057qib7 4484 14 in in IN cord-005453-4057qib7 4484 15 size size NN cord-005453-4057qib7 4484 16 . . . cord-005453-4057qib7 4485 1 There there EX cord-005453-4057qib7 4485 2 were be VBD cord-005453-4057qib7 4485 3 no no DT cord-005453-4057qib7 4485 4 distant distant JJ cord-005453-4057qib7 4485 5 and and CC cord-005453-4057qib7 4485 6 regional regional JJ cord-005453-4057qib7 4485 7 metastases metastasis NNS cord-005453-4057qib7 4485 8 on on IN cord-005453-4057qib7 4485 9 computerized computerized NN cord-005453-4057qib7 4485 10 tomography tomography NN cord-005453-4057qib7 4485 11 ( ( -LRB- cord-005453-4057qib7 4485 12 CT CT NNP cord-005453-4057qib7 4485 13 ) ) -RRB- cord-005453-4057qib7 4485 14 and and CC cord-005453-4057qib7 4485 15 scintigraphy scintigraphy NN cord-005453-4057qib7 4485 16 with with IN cord-005453-4057qib7 4485 17 99 99 CD cord-005453-4057qib7 4485 18 m m NN cord-005453-4057qib7 4485 19 Tc Tc NNP cord-005453-4057qib7 4485 20 . . . cord-005453-4057qib7 4486 1 The the DT cord-005453-4057qib7 4486 2 nodulus nodulus NN cord-005453-4057qib7 4486 3 and and CC cord-005453-4057qib7 4486 4 regional regional JJ cord-005453-4057qib7 4486 5 lymph lymph NN cord-005453-4057qib7 4486 6 nodes node NNS cord-005453-4057qib7 4486 7 were be VBD cord-005453-4057qib7 4486 8 radically radically RB cord-005453-4057qib7 4486 9 removed remove VBN cord-005453-4057qib7 4486 10 before before IN cord-005453-4057qib7 4486 11 HSCT HSCT NNP cord-005453-4057qib7 4486 12 . . . cord-005453-4057qib7 4487 1 The the DT cord-005453-4057qib7 4487 2 resection resection NN cord-005453-4057qib7 4487 3 margin margin NN cord-005453-4057qib7 4487 4 was be VBD cord-005453-4057qib7 4487 5 within within IN cord-005453-4057qib7 4487 6 the the DT cord-005453-4057qib7 4487 7 normal normal JJ cord-005453-4057qib7 4487 8 tissue tissue NN cord-005453-4057qib7 4487 9 . . . cord-005453-4057qib7 4488 1 Microscopically microscopically RB cord-005453-4057qib7 4488 2 the the DT cord-005453-4057qib7 4488 3 derma derma NN cord-005453-4057qib7 4488 4 and and CC cord-005453-4057qib7 4488 5 subcutaneous subcutaneous JJ cord-005453-4057qib7 4488 6 fat fat NN cord-005453-4057qib7 4488 7 were be VBD cord-005453-4057qib7 4488 8 infiltrated infiltrate VBN cord-005453-4057qib7 4488 9 with with IN cord-005453-4057qib7 4488 10 epithelioid epithelioid NN cord-005453-4057qib7 4488 11 and and CC cord-005453-4057qib7 4488 12 spindle spindle NN cord-005453-4057qib7 4488 13 cells cell NNS cord-005453-4057qib7 4488 14 with with IN cord-005453-4057qib7 4488 15 total total JJ cord-005453-4057qib7 4488 16 expression expression NN cord-005453-4057qib7 4488 17 of of IN cord-005453-4057qib7 4488 18 S100 S100 NNP cord-005453-4057qib7 4488 19 , , , cord-005453-4057qib7 4488 20 MelanA melana NN cord-005453-4057qib7 4488 21 , , , cord-005453-4057qib7 4488 22 MHB45 MHB45 NNP cord-005453-4057qib7 4488 23 , , , cord-005453-4057qib7 4488 24 CyclinD1 CyclinD1 NNP cord-005453-4057qib7 4488 25 . . . cord-005453-4057qib7 4489 1 Ki-67 Ki-67 . cord-005453-4057qib7 4490 1 expression expression NN cord-005453-4057qib7 4490 2 level level NN cord-005453-4057qib7 4490 3 was be VBD cord-005453-4057qib7 4490 4 15 15 CD cord-005453-4057qib7 4490 5 - - SYM cord-005453-4057qib7 4490 6 20 20 CD cord-005453-4057qib7 4490 7 % % NN cord-005453-4057qib7 4490 8 . . . cord-005453-4057qib7 4491 1 Histological histological JJ cord-005453-4057qib7 4491 2 structure structure NN cord-005453-4057qib7 4491 3 was be VBD cord-005453-4057qib7 4491 4 specific specific JJ cord-005453-4057qib7 4491 5 for for IN cord-005453-4057qib7 4491 6 PEM PEM NNP cord-005453-4057qib7 4491 7 . . . cord-005453-4057qib7 4492 1 HSCT HSCT NNP cord-005453-4057qib7 4492 2 with with IN cord-005453-4057qib7 4492 3 TCRαβ+/CD19 tcrαβ+/cd19 NN cord-005453-4057qib7 4492 4 + + CC cord-005453-4057qib7 4492 5 graft graft NN cord-005453-4057qib7 4492 6 depletion depletion NN cord-005453-4057qib7 4492 7 from from IN cord-005453-4057qib7 4492 8 match match NN cord-005453-4057qib7 4492 9 unrelated unrelated JJ cord-005453-4057qib7 4492 10 donor donor NN cord-005453-4057qib7 4492 11 was be VBD cord-005453-4057qib7 4492 12 performed perform VBN cord-005453-4057qib7 4492 13 . . . cord-005453-4057qib7 4493 1 The the DT cord-005453-4057qib7 4493 2 conditioning conditioning NN cord-005453-4057qib7 4493 3 regimen regimen NN cord-005453-4057qib7 4493 4 included include VBD cord-005453-4057qib7 4493 5 total total JJ cord-005453-4057qib7 4493 6 lymphoid lymphoid JJ cord-005453-4057qib7 4493 7 irradiation irradiation NN cord-005453-4057qib7 4493 8 2Gy 2gy NN cord-005453-4057qib7 4493 9 , , , cord-005453-4057qib7 4493 10 fludarabin fludarabin NNP cord-005453-4057qib7 4493 11 150 150 CD cord-005453-4057qib7 4493 12 mg/ mg/ NN cord-005453-4057qib7 4493 13 m m NN cord-005453-4057qib7 4493 14 2 2 CD cord-005453-4057qib7 4493 15 , , , cord-005453-4057qib7 4493 16 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 4493 17 40 40 CD cord-005453-4057qib7 4493 18 mg mg NNP cord-005453-4057qib7 4493 19 / / SYM cord-005453-4057qib7 4493 20 kg kg NNP cord-005453-4057qib7 4493 21 , , , cord-005453-4057qib7 4493 22 rabbit rabbit NN cord-005453-4057qib7 4493 23 ATG ATG NNP cord-005453-4057qib7 4493 24 5 5 CD cord-005453-4057qib7 4493 25 mg mg NNP cord-005453-4057qib7 4493 26 / / SYM cord-005453-4057qib7 4493 27 kg kg NNS cord-005453-4057qib7 4493 28 and and CC cord-005453-4057qib7 4494 1 rituximab rituximab RB cord-005453-4057qib7 4494 2 100 100 CD cord-005453-4057qib7 4494 3 mg mg NNP cord-005453-4057qib7 4494 4 / / SYM cord-005453-4057qib7 4494 5 m m NNP cord-005453-4057qib7 4494 6 2 2 CD cord-005453-4057qib7 4494 7 . . . cord-005453-4057qib7 4495 1 Results result NNS cord-005453-4057qib7 4495 2 : : : cord-005453-4057qib7 4496 1 At at IN cord-005453-4057qib7 4496 2 +45 +45 NNP cord-005453-4057qib7 4496 3 day day NN cord-005453-4057qib7 4496 4 after after IN cord-005453-4057qib7 4496 5 HSCT HSCT NNP cord-005453-4057qib7 4496 6 was be VBD cord-005453-4057qib7 4496 7 detected detect VBN cord-005453-4057qib7 4496 8 the the DT cord-005453-4057qib7 4496 9 tumor tumor NN cord-005453-4057qib7 4496 10 on on IN cord-005453-4057qib7 4496 11 the the DT cord-005453-4057qib7 4496 12 left left JJ cord-005453-4057qib7 4496 13 cheek cheek NN cord-005453-4057qib7 4496 14 and and CC cord-005453-4057qib7 4496 15 parotid parotid NN cord-005453-4057qib7 4496 16 region region NN cord-005453-4057qib7 4496 17 with with IN cord-005453-4057qib7 4496 18 a a DT cord-005453-4057qib7 4496 19 histological histological JJ cord-005453-4057qib7 4496 20 structure structure NN cord-005453-4057qib7 4496 21 identical identical JJ cord-005453-4057qib7 4496 22 to to IN cord-005453-4057qib7 4496 23 the the DT cord-005453-4057qib7 4496 24 primary primary JJ cord-005453-4057qib7 4496 25 lesion lesion NN cord-005453-4057qib7 4496 26 . . . cord-005453-4057qib7 4497 1 On on IN cord-005453-4057qib7 4497 2 CT CT NNP cord-005453-4057qib7 4497 3 in in IN cord-005453-4057qib7 4497 4 S6 S6 NNP cord-005453-4057qib7 4497 5 segment segment NN cord-005453-4057qib7 4497 6 of of IN cord-005453-4057qib7 4497 7 the the DT cord-005453-4057qib7 4497 8 left left JJ cord-005453-4057qib7 4497 9 lung lung NN cord-005453-4057qib7 4497 10 was be VBD cord-005453-4057qib7 4497 11 detected detect VBN cord-005453-4057qib7 4497 12 focus focus VBP cord-005453-4057qib7 4497 13 20x20 20x20 CD cord-005453-4057qib7 4497 14 mm mm NN cord-005453-4057qib7 4497 15 with with IN cord-005453-4057qib7 4497 16 a a DT cord-005453-4057qib7 4497 17 cavity cavity NN cord-005453-4057qib7 4497 18 . . . cord-005453-4057qib7 4498 1 Invasive invasive JJ cord-005453-4057qib7 4498 2 aspergillosis aspergillosis NN cord-005453-4057qib7 4498 3 was be VBD cord-005453-4057qib7 4498 4 suspected suspect VBN cord-005453-4057qib7 4498 5 and and CC cord-005453-4057qib7 4498 6 empirical empirical JJ cord-005453-4057qib7 4498 7 antifungal antifungal JJ cord-005453-4057qib7 4498 8 treatment treatment NN cord-005453-4057qib7 4498 9 was be VBD cord-005453-4057qib7 4498 10 started start VBN cord-005453-4057qib7 4498 11 . . . cord-005453-4057qib7 4499 1 But but CC cord-005453-4057qib7 4499 2 in in IN cord-005453-4057qib7 4499 3 15 15 CD cord-005453-4057qib7 4499 4 days day NNS cord-005453-4057qib7 4499 5 the the DT cord-005453-4057qib7 4499 6 lung lung NN cord-005453-4057qib7 4499 7 lesion lesion NN cord-005453-4057qib7 4499 8 increased increase VBD cord-005453-4057qib7 4499 9 in in IN cord-005453-4057qib7 4499 10 size size NN cord-005453-4057qib7 4499 11 to to IN cord-005453-4057qib7 4499 12 52x30x32 52x30x32 CD cord-005453-4057qib7 4499 13 mm mm NNS cord-005453-4057qib7 4499 14 and and CC cord-005453-4057qib7 4499 15 penetrated penetrate VBD cord-005453-4057qib7 4499 16 in in IN cord-005453-4057qib7 4499 17 the the DT cord-005453-4057qib7 4499 18 bronchus bronchus NN cord-005453-4057qib7 4499 19 . . . cord-005453-4057qib7 4500 1 After after IN cord-005453-4057qib7 4500 2 bronchoscopy bronchoscopy NN cord-005453-4057qib7 4500 3 with with IN cord-005453-4057qib7 4500 4 biopsy biopsy NN cord-005453-4057qib7 4500 5 , , , cord-005453-4057qib7 4500 6 PEM pem NN cord-005453-4057qib7 4500 7 metastasis metastasis NN cord-005453-4057qib7 4500 8 was be VBD cord-005453-4057qib7 4500 9 histologically histologically RB cord-005453-4057qib7 4500 10 confirmed confirm VBN cord-005453-4057qib7 4500 11 . . . cord-005453-4057qib7 4501 1 Moreover moreover RB cord-005453-4057qib7 4501 2 , , , cord-005453-4057qib7 4501 3 the the DT cord-005453-4057qib7 4501 4 tumor tumor NN cord-005453-4057qib7 4501 5 on on IN cord-005453-4057qib7 4501 6 the the DT cord-005453-4057qib7 4501 7 face face NN cord-005453-4057qib7 4501 8 continued continue VBD cord-005453-4057qib7 4501 9 to to TO cord-005453-4057qib7 4501 10 grow grow VB cord-005453-4057qib7 4501 11 . . . cord-005453-4057qib7 4502 1 Therapy therapy NN cord-005453-4057qib7 4502 2 with with IN cord-005453-4057qib7 4502 3 cobimetinib cobimetinib NN cord-005453-4057qib7 4502 4 and and CC cord-005453-4057qib7 4502 5 vemurafenib vemurafenib NN cord-005453-4057qib7 4502 6 was be VBD cord-005453-4057qib7 4502 7 not not RB cord-005453-4057qib7 4502 8 effective effective JJ cord-005453-4057qib7 4502 9 and and CC cord-005453-4057qib7 4502 10 patient patient JJ cord-005453-4057qib7 4502 11 died die VBD cord-005453-4057qib7 4502 12 from from IN cord-005453-4057qib7 4502 13 progression progression NN cord-005453-4057qib7 4502 14 of of IN cord-005453-4057qib7 4502 15 PEM PEM NNP cord-005453-4057qib7 4502 16 on on IN cord-005453-4057qib7 4502 17 +98 +98 NNP cord-005453-4057qib7 4502 18 day day NN cord-005453-4057qib7 4502 19 after after IN cord-005453-4057qib7 4502 20 HSCT HSCT NNP cord-005453-4057qib7 4502 21 . . . cord-005453-4057qib7 4503 1 Conclusions conclusion NNS cord-005453-4057qib7 4503 2 : : : cord-005453-4057qib7 4504 1 PEM PEM NNP cord-005453-4057qib7 4504 2 was be VBD cord-005453-4057qib7 4504 3 early early RB cord-005453-4057qib7 4504 4 described describe VBN cord-005453-4057qib7 4504 5 as as IN cord-005453-4057qib7 4504 6 indolent indolent JJ cord-005453-4057qib7 4504 7 tumor tumor NN cord-005453-4057qib7 4504 8 with with IN cord-005453-4057qib7 4504 9 rare rare JJ cord-005453-4057qib7 4504 10 distant distant JJ cord-005453-4057qib7 4504 11 metastasis metastasis NN cord-005453-4057qib7 4504 12 and and CC cord-005453-4057qib7 4504 13 favorable favorable JJ cord-005453-4057qib7 4504 14 prognosis prognosis NN cord-005453-4057qib7 4504 15 . . . cord-005453-4057qib7 4505 1 We -PRON- PRP cord-005453-4057qib7 4505 2 suspect suspect VBP cord-005453-4057qib7 4505 3 that that IN cord-005453-4057qib7 4505 4 PEM PEM NNP cord-005453-4057qib7 4505 5 may may MD cord-005453-4057qib7 4505 6 acquire acquire VB cord-005453-4057qib7 4505 7 an an DT cord-005453-4057qib7 4505 8 aggressive aggressive JJ cord-005453-4057qib7 4505 9 course course NN cord-005453-4057qib7 4505 10 in in IN cord-005453-4057qib7 4505 11 the the DT cord-005453-4057qib7 4505 12 absence absence NN cord-005453-4057qib7 4505 13 of of IN cord-005453-4057qib7 4505 14 immunological immunological JJ cord-005453-4057qib7 4505 15 control control NN cord-005453-4057qib7 4505 16 , , , cord-005453-4057qib7 4505 17 especially especially RB cord-005453-4057qib7 4505 18 in in IN cord-005453-4057qib7 4505 19 high high JJ cord-005453-4057qib7 4505 20 immunocompromised immunocompromised JJ cord-005453-4057qib7 4505 21 patients patient NNS cord-005453-4057qib7 4505 22 after after IN cord-005453-4057qib7 4505 23 HSCT HSCT NNP cord-005453-4057qib7 4505 24 . . . cord-005453-4057qib7 4506 1 Disclosure disclosure NN cord-005453-4057qib7 4506 2 : : : cord-005453-4057qib7 4506 3 Nothing nothing NN cord-005453-4057qib7 4506 4 to to TO cord-005453-4057qib7 4506 5 declare declare VB cord-005453-4057qib7 4506 6 P208 P208 NNP cord-005453-4057qib7 4506 7 Abstract Abstract NNP cord-005453-4057qib7 4506 8 withdrawn withdraw VBD cord-005453-4057qib7 4506 9 Lidia Lidia NNP cord-005453-4057qib7 4506 10 Gartcheva Gartcheva NNP cord-005453-4057qib7 4506 11 1 1 CD cord-005453-4057qib7 4506 12 , , , cord-005453-4057qib7 4506 13 Antoaneta Antoaneta NNP cord-005453-4057qib7 4506 14 Mihova Mihova NNP cord-005453-4057qib7 4506 15 1 1 CD cord-005453-4057qib7 4506 16 , , , cord-005453-4057qib7 4506 17 Penka Penka NNP cord-005453-4057qib7 4506 18 Ganeva Ganeva NNP cord-005453-4057qib7 4506 19 1 1 CD cord-005453-4057qib7 4506 20 , , , cord-005453-4057qib7 4506 21 Margarita Margarita NNP cord-005453-4057qib7 4506 22 Guenova Guenova NNP cord-005453-4057qib7 4506 23 1 1 CD cord-005453-4057qib7 4507 1 , , , cord-005453-4057qib7 4507 2 Branimir Branimir NNP cord-005453-4057qib7 4507 3 Spassov Spassov NNP cord-005453-4057qib7 4507 4 1 1 CD cord-005453-4057qib7 4507 5 Background Background NNP cord-005453-4057qib7 4507 6 : : : cord-005453-4057qib7 4508 1 The the DT cord-005453-4057qib7 4508 2 main main JJ cord-005453-4057qib7 4508 3 objective objective NN cord-005453-4057qib7 4508 4 of of IN cord-005453-4057qib7 4508 5 the the DT cord-005453-4057qib7 4508 6 study study NN cord-005453-4057qib7 4508 7 is be VBZ cord-005453-4057qib7 4508 8 to to TO cord-005453-4057qib7 4508 9 assess assess VB cord-005453-4057qib7 4508 10 the the DT cord-005453-4057qib7 4508 11 dynamics dynamic NNS cord-005453-4057qib7 4508 12 of of IN cord-005453-4057qib7 4508 13 quantitative quantitative JJ cord-005453-4057qib7 4508 14 and and CC cord-005453-4057qib7 4508 15 qualitative qualitative JJ cord-005453-4057qib7 4508 16 changes change NNS cord-005453-4057qib7 4508 17 in in IN cord-005453-4057qib7 4508 18 the the DT cord-005453-4057qib7 4508 19 parameters parameter NNS cord-005453-4057qib7 4508 20 of of IN cord-005453-4057qib7 4508 21 the the DT cord-005453-4057qib7 4508 22 B b NN cord-005453-4057qib7 4508 23 cell cell NN cord-005453-4057qib7 4508 24 population population NN cord-005453-4057qib7 4508 25 and and CC cord-005453-4057qib7 4508 26 the the DT cord-005453-4057qib7 4508 27 production production NN cord-005453-4057qib7 4508 28 of of IN cord-005453-4057qib7 4508 29 immunoglobulins immunoglobulin NNS cord-005453-4057qib7 4508 30 in in IN cord-005453-4057qib7 4508 31 patients patient NNS cord-005453-4057qib7 4508 32 after after IN cord-005453-4057qib7 4508 33 autologous autologous JJ cord-005453-4057qib7 4508 34 transplantation transplantation NN cord-005453-4057qib7 4508 35 of of IN cord-005453-4057qib7 4508 36 hematopoietic hematopoietic JJ cord-005453-4057qib7 4508 37 stem stem NN cord-005453-4057qib7 4508 38 cells cell NNS cord-005453-4057qib7 4508 39 in in IN cord-005453-4057qib7 4508 40 the the DT cord-005453-4057qib7 4508 41 course course NN cord-005453-4057qib7 4508 42 of of IN cord-005453-4057qib7 4508 43 recovery recovery NN cord-005453-4057qib7 4508 44 of of IN cord-005453-4057qib7 4508 45 the the DT cord-005453-4057qib7 4508 46 immune immune JJ cord-005453-4057qib7 4508 47 system system NN cord-005453-4057qib7 4508 48 . . . cord-005453-4057qib7 4509 1 Methods method NNS cord-005453-4057qib7 4509 2 : : : cord-005453-4057qib7 4509 3 56 56 CD cord-005453-4057qib7 4509 4 patients patient NNS cord-005453-4057qib7 4509 5 with with IN cord-005453-4057qib7 4509 6 hematological hematological JJ cord-005453-4057qib7 4509 7 neoplasms neoplasm NNS cord-005453-4057qib7 4509 8 undergoing undergo VBG cord-005453-4057qib7 4509 9 autologous autologous JJ cord-005453-4057qib7 4509 10 transplantation transplantation NN cord-005453-4057qib7 4509 11 were be VBD cord-005453-4057qib7 4509 12 included include VBN cord-005453-4057qib7 4509 13 in in IN cord-005453-4057qib7 4509 14 the the DT cord-005453-4057qib7 4509 15 study study NN cord-005453-4057qib7 4509 16 : : : cord-005453-4057qib7 4509 17 30 30 CD cord-005453-4057qib7 4509 18 women woman NNS cord-005453-4057qib7 4509 19 and and CC cord-005453-4057qib7 4509 20 26 26 CD cord-005453-4057qib7 4509 21 men man NNS cord-005453-4057qib7 4509 22 , , , cord-005453-4057qib7 4509 23 with with IN cord-005453-4057qib7 4509 24 an an DT cord-005453-4057qib7 4509 25 average average JJ cord-005453-4057qib7 4509 26 age age NN cord-005453-4057qib7 4509 27 of of IN cord-005453-4057qib7 4509 28 31 31 CD cord-005453-4057qib7 4509 29 years year NNS cord-005453-4057qib7 4509 30 . . . cord-005453-4057qib7 4510 1 Patients patient NNS cord-005453-4057qib7 4510 2 were be VBD cord-005453-4057qib7 4510 3 diagnosed diagnose VBN cord-005453-4057qib7 4510 4 with with IN cord-005453-4057qib7 4510 5 lymphoma lymphoma NN cord-005453-4057qib7 4510 6 ( ( -LRB- cord-005453-4057qib7 4510 7 n n NN cord-005453-4057qib7 4510 8 = = SYM cord-005453-4057qib7 4510 9 30 30 CD cord-005453-4057qib7 4510 10 ) ) -RRB- cord-005453-4057qib7 4510 11 , , , cord-005453-4057qib7 4510 12 multiple multiple JJ cord-005453-4057qib7 4510 13 myeloma myeloma NN cord-005453-4057qib7 4510 14 ( ( -LRB- cord-005453-4057qib7 4510 15 n=7 n=7 NNS cord-005453-4057qib7 4510 16 ) ) -RRB- cord-005453-4057qib7 4510 17 , , , cord-005453-4057qib7 4510 18 leukemia leukemia NN cord-005453-4057qib7 4510 19 ( ( -LRB- cord-005453-4057qib7 4510 20 n n NN cord-005453-4057qib7 4510 21 = = SYM cord-005453-4057qib7 4510 22 7 7 CD cord-005453-4057qib7 4510 23 ) ) -RRB- cord-005453-4057qib7 4510 24 and and CC cord-005453-4057qib7 4510 25 solid solid JJ cord-005453-4057qib7 4510 26 tumors tumor NNS cord-005453-4057qib7 4510 27 ( ( -LRB- cord-005453-4057qib7 4510 28 n n NN cord-005453-4057qib7 4510 29 = = SYM cord-005453-4057qib7 4510 30 12 12 CD cord-005453-4057qib7 4510 31 ) ) -RRB- cord-005453-4057qib7 4510 32 . . . cord-005453-4057qib7 4511 1 At at IN cord-005453-4057qib7 4511 2 the the DT cord-005453-4057qib7 4511 3 time time NN cord-005453-4057qib7 4511 4 of of IN cord-005453-4057qib7 4511 5 transplantation transplantation NN cord-005453-4057qib7 4511 6 , , , cord-005453-4057qib7 4511 7 16 16 CD cord-005453-4057qib7 4511 8 patients patient NNS cord-005453-4057qib7 4511 9 were be VBD cord-005453-4057qib7 4511 10 in in IN cord-005453-4057qib7 4511 11 complete complete JJ cord-005453-4057qib7 4511 12 clinical clinical JJ cord-005453-4057qib7 4511 13 remission remission NN cord-005453-4057qib7 4511 14 or or CC cord-005453-4057qib7 4511 15 at at IN cord-005453-4057qib7 4511 16 least least JJS cord-005453-4057qib7 4511 17 with with IN cord-005453-4057qib7 4511 18 very very RB cord-005453-4057qib7 4511 19 good good JJ cord-005453-4057qib7 4511 20 partial partial JJ cord-005453-4057qib7 4511 21 response response NN cord-005453-4057qib7 4511 22 , , , cord-005453-4057qib7 4511 23 30 30 CD cord-005453-4057qib7 4511 24 patients patient NNS cord-005453-4057qib7 4511 25 were be VBD cord-005453-4057qib7 4511 26 in in IN cord-005453-4057qib7 4511 27 partial partial JJ cord-005453-4057qib7 4511 28 remission remission NN cord-005453-4057qib7 4511 29 and and CC cord-005453-4057qib7 4512 1 10 10 CD cord-005453-4057qib7 4512 2 patients patient NNS cord-005453-4057qib7 4512 3 -with -with CD cord-005453-4057qib7 4512 4 progression progression NN cord-005453-4057qib7 4512 5 . . . cord-005453-4057qib7 4513 1 All all DT cord-005453-4057qib7 4513 2 patients patient NNS cord-005453-4057qib7 4513 3 were be VBD cord-005453-4057qib7 4513 4 evaluated evaluate VBN cord-005453-4057qib7 4513 5 in in IN cord-005453-4057qib7 4513 6 nine nine CD cord-005453-4057qib7 4513 7 time time NN cord-005453-4057qib7 4513 8 points point VBZ cord-005453-4057qib7 4513 9 through through IN cord-005453-4057qib7 4513 10 356 356 CD cord-005453-4057qib7 4513 11 examinations examination NNS cord-005453-4057qib7 4513 12 by by IN cord-005453-4057qib7 4513 13 clinical clinical JJ cord-005453-4057qib7 4513 14 - - HYPH cord-005453-4057qib7 4513 15 laboratory laboratory NN cord-005453-4057qib7 4513 16 , , , cord-005453-4057qib7 4513 17 flow flow NN cord-005453-4057qib7 4513 18 cytometric cytometric NNP cord-005453-4057qib7 4513 19 and and CC cord-005453-4057qib7 4513 20 immunochemical immunochemical JJ cord-005453-4057qib7 4513 21 methods method NNS cord-005453-4057qib7 4513 22 . . . cord-005453-4057qib7 4514 1 Results result NNS cord-005453-4057qib7 4514 2 : : : cord-005453-4057qib7 4515 1 The the DT cord-005453-4057qib7 4515 2 percentage percentage NN cord-005453-4057qib7 4515 3 of of IN cord-005453-4057qib7 4515 4 CD19 CD19 NNP cord-005453-4057qib7 4515 5 ( ( -LRB- cord-005453-4057qib7 4515 6 + + NN cord-005453-4057qib7 4515 7 ) ) -RRB- cord-005453-4057qib7 4515 8 B b NN cord-005453-4057qib7 4515 9 cells cell NNS cord-005453-4057qib7 4515 10 reached reach VBD cord-005453-4057qib7 4515 11 the the DT cord-005453-4057qib7 4515 12 minimum minimum JJ cord-005453-4057qib7 4515 13 values value NNS cord-005453-4057qib7 4515 14 one one CD cord-005453-4057qib7 4515 15 month month NN cord-005453-4057qib7 4515 16 after after IN cord-005453-4057qib7 4515 17 transplantation transplantation NN cord-005453-4057qib7 4515 18 then then RB cord-005453-4057qib7 4515 19 began begin VBD cord-005453-4057qib7 4515 20 to to TO cord-005453-4057qib7 4515 21 increase increase VB cord-005453-4057qib7 4515 22 in in IN cord-005453-4057qib7 4515 23 the the DT cord-005453-4057qib7 4515 24 second second JJ cord-005453-4057qib7 4515 25 month month NN cord-005453-4057qib7 4515 26 reaching reach VBG cord-005453-4057qib7 4515 27 a a DT cord-005453-4057qib7 4515 28 plateau plateau NN cord-005453-4057qib7 4515 29 around around IN cord-005453-4057qib7 4515 30 the the DT cord-005453-4057qib7 4515 31 mean mean JJ cord-005453-4057qib7 4515 32 values value NNS cord-005453-4057qib7 4515 33 in in IN cord-005453-4057qib7 4515 34 the the DT cord-005453-4057qib7 4515 35 period period NN cord-005453-4057qib7 4515 36 6 6 CD cord-005453-4057qib7 4515 37 - - SYM cord-005453-4057qib7 4515 38 12 12 CD cord-005453-4057qib7 4515 39 months month NNS cord-005453-4057qib7 4515 40 after after IN cord-005453-4057qib7 4515 41 transplantation transplantation NN cord-005453-4057qib7 4515 42 . . . cord-005453-4057qib7 4516 1 The the DT cord-005453-4057qib7 4516 2 absolute absolute JJ cord-005453-4057qib7 4516 3 number number NN cord-005453-4057qib7 4516 4 remained remain VBD cord-005453-4057qib7 4516 5 low low JJ cord-005453-4057qib7 4516 6 during during IN cord-005453-4057qib7 4516 7 the the DT cord-005453-4057qib7 4516 8 entire entire JJ cord-005453-4057qib7 4516 9 period period NN cord-005453-4057qib7 4516 10 of of IN cord-005453-4057qib7 4516 11 observation observation NN cord-005453-4057qib7 4516 12 . . . cord-005453-4057qib7 4517 1 The the DT cord-005453-4057qib7 4517 2 amounts amount NNS cord-005453-4057qib7 4517 3 of of IN cord-005453-4057qib7 4517 4 IgG IgG NNP cord-005453-4057qib7 4517 5 and and CC cord-005453-4057qib7 4517 6 IgM IgM NNP cord-005453-4057qib7 4517 7 serum serum NN cord-005453-4057qib7 4517 8 immunoglobulins immunoglobulin NNS cord-005453-4057qib7 4517 9 gradually gradually RB cord-005453-4057qib7 4517 10 increased increase VBD cord-005453-4057qib7 4517 11 within within IN cord-005453-4057qib7 4517 12 the the DT cord-005453-4057qib7 4517 13 reference reference NN cord-005453-4057qib7 4517 14 range range NN cord-005453-4057qib7 4517 15 throughout throughout IN cord-005453-4057qib7 4517 16 the the DT cord-005453-4057qib7 4517 17 entire entire JJ cord-005453-4057qib7 4517 18 period period NN cord-005453-4057qib7 4517 19 , , , cord-005453-4057qib7 4517 20 while while IN cord-005453-4057qib7 4517 21 the the DT cord-005453-4057qib7 4517 22 IgA IgA NNP cord-005453-4057qib7 4517 23 level level NN cord-005453-4057qib7 4517 24 varied varied JJ cord-005453-4057qib7 4517 25 around around IN cord-005453-4057qib7 4517 26 the the DT cord-005453-4057qib7 4517 27 lower low JJR cord-005453-4057qib7 4517 28 reference reference NN cord-005453-4057qib7 4517 29 range range NN cord-005453-4057qib7 4517 30 . . . cord-005453-4057qib7 4518 1 Conclusions conclusion NNS cord-005453-4057qib7 4518 2 : : : cord-005453-4057qib7 4519 1 Implementation implementation NN cord-005453-4057qib7 4519 2 of of IN cord-005453-4057qib7 4519 3 an an DT cord-005453-4057qib7 4519 4 adequate adequate JJ cord-005453-4057qib7 4519 5 humoral humoral JJ cord-005453-4057qib7 4519 6 immune immune JJ cord-005453-4057qib7 4519 7 response response NN cord-005453-4057qib7 4519 8 is be VBZ cord-005453-4057qib7 4519 9 hampered hamper VBN cord-005453-4057qib7 4519 10 by by IN cord-005453-4057qib7 4519 11 the the DT cord-005453-4057qib7 4519 12 reduction reduction NN cord-005453-4057qib7 4519 13 of of IN cord-005453-4057qib7 4519 14 circulating circulate VBG cord-005453-4057qib7 4519 15 B b NN cord-005453-4057qib7 4519 16 cells cell NNS cord-005453-4057qib7 4519 17 , , , cord-005453-4057qib7 4519 18 suppressed suppress VBD cord-005453-4057qib7 4519 19 proliferative proliferative JJ cord-005453-4057qib7 4519 20 potential potential JJ cord-005453-4057qib7 4519 21 and and CC cord-005453-4057qib7 4519 22 functional functional JJ cord-005453-4057qib7 4519 23 deficits deficit NNS cord-005453-4057qib7 4519 24 . . . cord-005453-4057qib7 4520 1 Restoration restoration NN cord-005453-4057qib7 4520 2 of of IN cord-005453-4057qib7 4520 3 B b NN cord-005453-4057qib7 4520 4 - - HYPH cord-005453-4057qib7 4520 5 cell cell NN cord-005453-4057qib7 4520 6 function function NN cord-005453-4057qib7 4520 7 occurs occur VBZ cord-005453-4057qib7 4520 8 over over IN cord-005453-4057qib7 4520 9 a a DT cord-005453-4057qib7 4520 10 period period NN cord-005453-4057qib7 4520 11 of of IN cord-005453-4057qib7 4520 12 6 6 CD cord-005453-4057qib7 4520 13 months month NNS cord-005453-4057qib7 4520 14 to to IN cord-005453-4057qib7 4520 15 2 2 CD cord-005453-4057qib7 4520 16 years year NNS cord-005453-4057qib7 4520 17 after after IN cord-005453-4057qib7 4520 18 autologous autologous JJ cord-005453-4057qib7 4520 19 transplantation transplantation NN cord-005453-4057qib7 4520 20 . . . cord-005453-4057qib7 4521 1 Clinical clinical JJ cord-005453-4057qib7 4521 2 Trial Trial NNP cord-005453-4057qib7 4521 3 Registry Registry NNP cord-005453-4057qib7 4521 4 : : : cord-005453-4057qib7 4521 5 no no DT cord-005453-4057qib7 4521 6 clinical clinical JJ cord-005453-4057qib7 4521 7 trials trial NNS cord-005453-4057qib7 4522 1 Disclosure disclosure NN cord-005453-4057qib7 4522 2 : : : cord-005453-4057qib7 4523 1 Nothing nothing NN cord-005453-4057qib7 4523 2 to to TO cord-005453-4057qib7 4523 3 declare declare VB cord-005453-4057qib7 4523 4 Justyna Justyna NNP cord-005453-4057qib7 4523 5 Background Background NNP cord-005453-4057qib7 4523 6 : : : cord-005453-4057qib7 4523 7 Allogeneic allogeneic NN cord-005453-4057qib7 4523 8 hematopoietic hematopoietic JJ cord-005453-4057qib7 4523 9 stem stem NN cord-005453-4057qib7 4523 10 cells cell NNS cord-005453-4057qib7 4523 11 transplantation transplantation NN cord-005453-4057qib7 4523 12 ( ( -LRB- cord-005453-4057qib7 4523 13 allo allo NN cord-005453-4057qib7 4523 14 - - HYPH cord-005453-4057qib7 4523 15 HSCT HSCT NNP cord-005453-4057qib7 4523 16 ) ) -RRB- cord-005453-4057qib7 4523 17 is be VBZ cord-005453-4057qib7 4523 18 a a DT cord-005453-4057qib7 4523 19 life life NN cord-005453-4057qib7 4523 20 - - HYPH cord-005453-4057qib7 4523 21 saving save VBG cord-005453-4057qib7 4523 22 and and CC cord-005453-4057qib7 4523 23 well well RB cord-005453-4057qib7 4523 24 established establish VBN cord-005453-4057qib7 4523 25 therapy therapy NN cord-005453-4057qib7 4523 26 for for IN cord-005453-4057qib7 4523 27 wide wide JJ cord-005453-4057qib7 4523 28 range range NN cord-005453-4057qib7 4523 29 of of IN cord-005453-4057qib7 4523 30 diseases disease NNS cord-005453-4057qib7 4523 31 . . . cord-005453-4057qib7 4524 1 However however RB cord-005453-4057qib7 4524 2 , , , cord-005453-4057qib7 4524 3 it -PRON- PRP cord-005453-4057qib7 4524 4 is be VBZ cord-005453-4057qib7 4524 5 still still RB cord-005453-4057qib7 4524 6 uncommon uncommon JJ cord-005453-4057qib7 4524 7 treatment treatment NN cord-005453-4057qib7 4524 8 for for IN cord-005453-4057qib7 4524 9 infants infant NNS cord-005453-4057qib7 4524 10 less less JJR cord-005453-4057qib7 4524 11 than than IN cord-005453-4057qib7 4524 12 12 12 CD cord-005453-4057qib7 4524 13 months month NNS cord-005453-4057qib7 4524 14 of of IN cord-005453-4057qib7 4524 15 age age NN cord-005453-4057qib7 4524 16 . . . cord-005453-4057qib7 4525 1 The the DT cord-005453-4057qib7 4525 2 data datum NNS cord-005453-4057qib7 4525 3 about about IN cord-005453-4057qib7 4525 4 indications indication NNS cord-005453-4057qib7 4525 5 and and CC cord-005453-4057qib7 4525 6 outcome outcome NN cord-005453-4057qib7 4525 7 of of IN cord-005453-4057qib7 4525 8 allo allo NN cord-005453-4057qib7 4525 9 - - HYPH cord-005453-4057qib7 4525 10 HSCT HSCT NNP cord-005453-4057qib7 4525 11 in in IN cord-005453-4057qib7 4525 12 the the DT cord-005453-4057qib7 4525 13 youngest young JJS cord-005453-4057qib7 4525 14 group group NN cord-005453-4057qib7 4525 15 of of IN cord-005453-4057qib7 4525 16 patients patient NNS cord-005453-4057qib7 4525 17 is be VBZ cord-005453-4057qib7 4525 18 sparse sparse JJ cord-005453-4057qib7 4525 19 . . . cord-005453-4057qib7 4526 1 The the DT cord-005453-4057qib7 4526 2 primary primary JJ cord-005453-4057qib7 4526 3 objective objective NN cord-005453-4057qib7 4526 4 of of IN cord-005453-4057qib7 4526 5 this this DT cord-005453-4057qib7 4526 6 study study NN cord-005453-4057qib7 4526 7 was be VBD cord-005453-4057qib7 4526 8 to to TO cord-005453-4057qib7 4526 9 assess assess VB cord-005453-4057qib7 4526 10 the the DT cord-005453-4057qib7 4526 11 incidence incidence NN cord-005453-4057qib7 4526 12 , , , cord-005453-4057qib7 4526 13 indications indication NNS cord-005453-4057qib7 4526 14 , , , cord-005453-4057qib7 4526 15 post post JJ cord-005453-4057qib7 4526 16 - - JJ cord-005453-4057qib7 4526 17 HSCT hsct JJ cord-005453-4057qib7 4526 18 complications complication NNS cord-005453-4057qib7 4526 19 and and CC cord-005453-4057qib7 4526 20 general general JJ cord-005453-4057qib7 4526 21 outcome outcome NN cord-005453-4057qib7 4526 22 of of IN cord-005453-4057qib7 4526 23 allo allo NN cord-005453-4057qib7 4526 24 - - HYPH cord-005453-4057qib7 4526 25 HSCT HSCT NNP cord-005453-4057qib7 4526 26 among among IN cord-005453-4057qib7 4526 27 infants infant NNS cord-005453-4057qib7 4526 28 not not RB cord-005453-4057qib7 4526 29 older old JJR cord-005453-4057qib7 4526 30 than than IN cord-005453-4057qib7 4526 31 12 12 CD cord-005453-4057qib7 4526 32 months month NNS cord-005453-4057qib7 4526 33 . . . cord-005453-4057qib7 4527 1 Latter latter JJ cord-005453-4057qib7 4527 2 sequelae sequela NNS cord-005453-4057qib7 4527 3 of of IN cord-005453-4057qib7 4527 4 HSCT HSCT NNP cord-005453-4057qib7 4527 5 such such JJ cord-005453-4057qib7 4527 6 as as IN cord-005453-4057qib7 4527 7 physical physical JJ cord-005453-4057qib7 4527 8 and and CC cord-005453-4057qib7 4527 9 cognitive cognitive JJ cord-005453-4057qib7 4527 10 development development NN cord-005453-4057qib7 4527 11 were be VBD cord-005453-4057qib7 4527 12 secondary secondary JJ cord-005453-4057qib7 4527 13 aim aim NN cord-005453-4057qib7 4527 14 of of IN cord-005453-4057qib7 4527 15 this this DT cord-005453-4057qib7 4527 16 study study NN cord-005453-4057qib7 4527 17 . . . cord-005453-4057qib7 4528 1 Methods method NNS cord-005453-4057qib7 4528 2 : : : cord-005453-4057qib7 4528 3 We -PRON- PRP cord-005453-4057qib7 4528 4 retrospectively retrospectively RB cord-005453-4057qib7 4528 5 analyzed analyze VBD cord-005453-4057qib7 4528 6 data datum NNS cord-005453-4057qib7 4528 7 of of IN cord-005453-4057qib7 4528 8 63 63 CD cord-005453-4057qib7 4528 9 patients patient NNS cord-005453-4057qib7 4528 10 who who WP cord-005453-4057qib7 4528 11 underwent undergo VBD cord-005453-4057qib7 4528 12 allo allo NN cord-005453-4057qib7 4528 13 - - HYPH cord-005453-4057qib7 4528 14 HSCT HSCT NNP cord-005453-4057qib7 4528 15 before before IN cord-005453-4057qib7 4528 16 1 1 CD cord-005453-4057qib7 4528 17 year year NN cord-005453-4057qib7 4528 18 of of IN cord-005453-4057qib7 4528 19 age age NN cord-005453-4057qib7 4528 20 in in IN cord-005453-4057qib7 4528 21 Department Department NNP cord-005453-4057qib7 4528 22 of of IN cord-005453-4057qib7 4528 23 Pediatric Pediatric NNP cord-005453-4057qib7 4528 24 Hematology Hematology NNP cord-005453-4057qib7 4528 25 , , , cord-005453-4057qib7 4528 26 Oncology Oncology NNP cord-005453-4057qib7 4528 27 and and CC cord-005453-4057qib7 4528 28 Bone Bone NNP cord-005453-4057qib7 4528 29 Marrow Marrow NNP cord-005453-4057qib7 4528 30 Transplantation transplantation NN cord-005453-4057qib7 4528 31 in in IN cord-005453-4057qib7 4528 32 Wrocław Wrocław NNP cord-005453-4057qib7 4528 33 during during IN cord-005453-4057qib7 4528 34 years year NNS cord-005453-4057qib7 4528 35 1999 1999 CD cord-005453-4057qib7 4528 36 - - SYM cord-005453-4057qib7 4528 37 2017 2017 CD cord-005453-4057qib7 4528 38 . . . cord-005453-4057qib7 4529 1 Clinical clinical JJ cord-005453-4057qib7 4529 2 and and CC cord-005453-4057qib7 4529 3 epidemiological epidemiological JJ cord-005453-4057qib7 4529 4 features feature NNS cord-005453-4057qib7 4529 5 as as RB cord-005453-4057qib7 4529 6 well well RB cord-005453-4057qib7 4529 7 as as IN cord-005453-4057qib7 4529 8 indications indication NNS cord-005453-4057qib7 4529 9 for for IN cord-005453-4057qib7 4529 10 transplantation transplantation NN cord-005453-4057qib7 4529 11 , , , cord-005453-4057qib7 4529 12 early early JJ cord-005453-4057qib7 4529 13 and and CC cord-005453-4057qib7 4529 14 late late JJ cord-005453-4057qib7 4529 15 complications complication NNS cord-005453-4057qib7 4529 16 and and CC cord-005453-4057qib7 4529 17 general general JJ cord-005453-4057qib7 4529 18 outcome outcome NN cord-005453-4057qib7 4529 19 were be VBD cord-005453-4057qib7 4529 20 assessed assess VBN cord-005453-4057qib7 4529 21 . . . cord-005453-4057qib7 4530 1 Results result NNS cord-005453-4057qib7 4530 2 : : : cord-005453-4057qib7 4531 1 Infants infant NNS cord-005453-4057qib7 4531 2 who who WP cord-005453-4057qib7 4531 3 underwent undergo VBD cord-005453-4057qib7 4531 4 HSCT HSCT NNP cord-005453-4057qib7 4531 5 in in IN cord-005453-4057qib7 4531 6 our -PRON- PRP$ cord-005453-4057qib7 4531 7 Department Department NNP cord-005453-4057qib7 4531 8 comprise comprise VBP cord-005453-4057qib7 4531 9 8.2 8.2 CD cord-005453-4057qib7 4531 10 % % NN cord-005453-4057qib7 4531 11 of of IN cord-005453-4057qib7 4531 12 all all DT cord-005453-4057qib7 4531 13 patients patient NNS cord-005453-4057qib7 4531 14 undergoing undergo VBG cord-005453-4057qib7 4531 15 HSCT HSCT NNP cord-005453-4057qib7 4531 16 in in IN cord-005453-4057qib7 4531 17 analyzed analyze VBN cord-005453-4057qib7 4531 18 period period NN cord-005453-4057qib7 4531 19 of of IN cord-005453-4057qib7 4531 20 time time NN cord-005453-4057qib7 4531 21 . . . cord-005453-4057qib7 4532 1 Thirty thirty CD cord-005453-4057qib7 4532 2 - - HYPH cord-005453-4057qib7 4532 3 one one CD cord-005453-4057qib7 4532 4 ( ( -LRB- cord-005453-4057qib7 4532 5 49.2 49.2 CD cord-005453-4057qib7 4532 6 % % NN cord-005453-4057qib7 4532 7 ) ) -RRB- cord-005453-4057qib7 4532 8 patients patient NNS cord-005453-4057qib7 4532 9 received receive VBD cord-005453-4057qib7 4532 10 stem stem NN cord-005453-4057qib7 4532 11 cells cell NNS cord-005453-4057qib7 4532 12 from from IN cord-005453-4057qib7 4532 13 matched match VBN cord-005453-4057qib7 4532 14 unrelated unrelated JJ cord-005453-4057qib7 4532 15 donor donor NN cord-005453-4057qib7 4532 16 ( ( -LRB- cord-005453-4057qib7 4532 17 MUD MUD NNP cord-005453-4057qib7 4532 18 ) ) -RRB- cord-005453-4057qib7 4532 19 , , , cord-005453-4057qib7 4532 20 26 26 CD cord-005453-4057qib7 4532 21 ( ( -LRB- cord-005453-4057qib7 4532 22 41.3 41.3 CD cord-005453-4057qib7 4532 23 % % NN cord-005453-4057qib7 4532 24 ) ) -RRB- cord-005453-4057qib7 4532 25 from from IN cord-005453-4057qib7 4532 26 mismatched mismatched JJ cord-005453-4057qib7 4532 27 ( ( -LRB- cord-005453-4057qib7 4532 28 haploidentical haploidentical JJ cord-005453-4057qib7 4532 29 ) ) -RRB- cord-005453-4057qib7 4532 30 related related JJ cord-005453-4057qib7 4532 31 donor donor NN cord-005453-4057qib7 4532 32 ( ( -LRB- cord-005453-4057qib7 4532 33 MMRD MMRD NNP cord-005453-4057qib7 4532 34 ) ) -RRB- cord-005453-4057qib7 4532 35 and and CC cord-005453-4057qib7 4532 36 6 6 CD cord-005453-4057qib7 4532 37 ( ( -LRB- cord-005453-4057qib7 4532 38 9.5 9.5 CD cord-005453-4057qib7 4532 39 % % NN cord-005453-4057qib7 4532 40 ) ) -RRB- cord-005453-4057qib7 4532 41 from from IN cord-005453-4057qib7 4532 42 a a DT cord-005453-4057qib7 4532 43 sibling sibling NN cord-005453-4057qib7 4532 44 donor donor NN cord-005453-4057qib7 4532 45 ( ( -LRB- cord-005453-4057qib7 4532 46 MSD MSD NNP cord-005453-4057qib7 4532 47 ) ) -RRB- cord-005453-4057qib7 4532 48 . . . cord-005453-4057qib7 4533 1 Non non JJ cord-005453-4057qib7 4533 2 - - JJ cord-005453-4057qib7 4533 3 malignant malignant JJ cord-005453-4057qib7 4533 4 disorders disorder NNS cord-005453-4057qib7 4533 5 were be VBD cord-005453-4057qib7 4533 6 indication indication NN cord-005453-4057qib7 4533 7 for for IN cord-005453-4057qib7 4533 8 transplant transplant NN cord-005453-4057qib7 4533 9 in in IN cord-005453-4057qib7 4533 10 49 49 CD cord-005453-4057qib7 4533 11 ( ( -LRB- cord-005453-4057qib7 4533 12 77.8 77.8 CD cord-005453-4057qib7 4533 13 % % NN cord-005453-4057qib7 4533 14 ) ) -RRB- cord-005453-4057qib7 4533 15 patients patient NNS cord-005453-4057qib7 4533 16 and and CC cord-005453-4057qib7 4533 17 malignant malignant JJ cord-005453-4057qib7 4533 18 diseases disease NNS cord-005453-4057qib7 4533 19 in in IN cord-005453-4057qib7 4533 20 14 14 CD cord-005453-4057qib7 4533 21 ( ( -LRB- cord-005453-4057qib7 4533 22 22.2 22.2 CD cord-005453-4057qib7 4533 23 % % NN cord-005453-4057qib7 4533 24 ) ) -RRB- cord-005453-4057qib7 4533 25 . . . cord-005453-4057qib7 4534 1 Acute acute JJ cord-005453-4057qib7 4534 2 graft graft NN cord-005453-4057qib7 4534 3 versus versus IN cord-005453-4057qib7 4534 4 host host NN cord-005453-4057qib7 4534 5 disease disease NN cord-005453-4057qib7 4534 6 ( ( -LRB- cord-005453-4057qib7 4534 7 aGvHD agvhd NN cord-005453-4057qib7 4534 8 ) ) -RRB- cord-005453-4057qib7 4534 9 occurred occur VBD cord-005453-4057qib7 4534 10 in in IN cord-005453-4057qib7 4534 11 33 33 CD cord-005453-4057qib7 4534 12 ( ( -LRB- cord-005453-4057qib7 4534 13 52 52 CD cord-005453-4057qib7 4534 14 % % NN cord-005453-4057qib7 4534 15 ) ) -RRB- cord-005453-4057qib7 4534 16 infants infant NNS cord-005453-4057qib7 4534 17 , , , cord-005453-4057qib7 4534 18 chronic chronic JJ cord-005453-4057qib7 4534 19 graft graft NN cord-005453-4057qib7 4534 20 versus versus IN cord-005453-4057qib7 4534 21 host host NN cord-005453-4057qib7 4534 22 disease disease NN cord-005453-4057qib7 4534 23 ( ( -LRB- cord-005453-4057qib7 4534 24 cGvHD cGvHD NNP cord-005453-4057qib7 4534 25 ) ) -RRB- cord-005453-4057qib7 4534 26 in in IN cord-005453-4057qib7 4534 27 15 15 CD cord-005453-4057qib7 4534 28 ( ( -LRB- cord-005453-4057qib7 4534 29 24 24 CD cord-005453-4057qib7 4534 30 % % NN cord-005453-4057qib7 4534 31 ) ) -RRB- cord-005453-4057qib7 4534 32 . . . cord-005453-4057qib7 4535 1 Majority majority NN cord-005453-4057qib7 4535 2 of of IN cord-005453-4057qib7 4535 3 graft graft NN cord-005453-4057qib7 4535 4 rejections rejection NNS cord-005453-4057qib7 4535 5 were be VBD cord-005453-4057qib7 4535 6 seen see VBN cord-005453-4057qib7 4535 7 in in IN cord-005453-4057qib7 4535 8 infants infant NNS cord-005453-4057qib7 4535 9 transplanted transplant VBN cord-005453-4057qib7 4535 10 from from IN cord-005453-4057qib7 4535 11 MMRD MMRD NNP cord-005453-4057qib7 4535 12 7(63.6 7(63.6 CD cord-005453-4057qib7 4535 13 % % NN cord-005453-4057qib7 4535 14 ) ) -RRB- cord-005453-4057qib7 4535 15 , , , cord-005453-4057qib7 4535 16 whereas whereas IN cord-005453-4057qib7 4535 17 the the DT cord-005453-4057qib7 4535 18 rest rest NN cord-005453-4057qib7 4535 19 4 4 CD cord-005453-4057qib7 4535 20 ( ( -LRB- cord-005453-4057qib7 4535 21 36.4 36.4 CD cord-005453-4057qib7 4535 22 % % NN cord-005453-4057qib7 4535 23 ) ) -RRB- cord-005453-4057qib7 4535 24 was be VBD cord-005453-4057qib7 4535 25 associated associate VBN cord-005453-4057qib7 4535 26 with with IN cord-005453-4057qib7 4535 27 MUD mud NN cord-005453-4057qib7 4535 28 . . . cord-005453-4057qib7 4536 1 Median median JJ cord-005453-4057qib7 4536 2 follow follow NN cord-005453-4057qib7 4536 3 - - HYPH cord-005453-4057qib7 4536 4 up up NN cord-005453-4057qib7 4536 5 in in IN cord-005453-4057qib7 4536 6 study study NN cord-005453-4057qib7 4536 7 cohort cohort NN cord-005453-4057qib7 4536 8 was be VBD cord-005453-4057qib7 4536 9 860 860 CD cord-005453-4057qib7 4536 10 days day NNS cord-005453-4057qib7 4536 11 , , , cord-005453-4057qib7 4536 12 1148 1148 CD cord-005453-4057qib7 4536 13 days day NNS cord-005453-4057qib7 4536 14 for for IN cord-005453-4057qib7 4536 15 alive alive JJ cord-005453-4057qib7 4536 16 patients patient NNS cord-005453-4057qib7 4536 17 ( ( -LRB- cord-005453-4057qib7 4536 18 range range VBP cord-005453-4057qib7 4536 19 72 72 CD cord-005453-4057qib7 4536 20 days-19.5 days-19.5 NNP cord-005453-4057qib7 4536 21 yrs yr NNS cord-005453-4057qib7 4536 22 ) ) -RRB- cord-005453-4057qib7 4536 23 and and CC cord-005453-4057qib7 4536 24 72 72 CD cord-005453-4057qib7 4536 25 days day NNS cord-005453-4057qib7 4536 26 for for IN cord-005453-4057qib7 4536 27 those those DT cord-005453-4057qib7 4536 28 deceased deceased JJ cord-005453-4057qib7 4536 29 ( ( -LRB- cord-005453-4057qib7 4536 30 range range NN cord-005453-4057qib7 4536 31 3 3 CD cord-005453-4057qib7 4536 32 days-341 days-341 NNP cord-005453-4057qib7 4536 33 days day NNS cord-005453-4057qib7 4536 34 ) ) -RRB- cord-005453-4057qib7 4536 35 . . . cord-005453-4057qib7 4537 1 Overall overall JJ cord-005453-4057qib7 4537 2 survival survival NN cord-005453-4057qib7 4537 3 ( ( -LRB- cord-005453-4057qib7 4537 4 OS OS NNP cord-005453-4057qib7 4537 5 ) ) -RRB- cord-005453-4057qib7 4537 6 in in IN cord-005453-4057qib7 4537 7 study study NN cord-005453-4057qib7 4537 8 cohort cohort NN cord-005453-4057qib7 4537 9 was be VBD cord-005453-4057qib7 4537 10 0.682 0.682 CD cord-005453-4057qib7 4537 11 and and CC cord-005453-4057qib7 4537 12 transplant transplant NN cord-005453-4057qib7 4537 13 related relate VBN cord-005453-4057qib7 4537 14 mortality mortality NN cord-005453-4057qib7 4537 15 ( ( -LRB- cord-005453-4057qib7 4537 16 TRM TRM NNP cord-005453-4057qib7 4537 17 ) ) -RRB- cord-005453-4057qib7 4537 18 was be VBD cord-005453-4057qib7 4537 19 0.317 0.317 CD cord-005453-4057qib7 4537 20 . . . cord-005453-4057qib7 4538 1 In in IN cord-005453-4057qib7 4538 2 children child NNS cord-005453-4057qib7 4538 3 with with IN cord-005453-4057qib7 4538 4 malignancy malignancy NN cord-005453-4057qib7 4538 5 5 5 CD cord-005453-4057qib7 4538 6 ( ( -LRB- cord-005453-4057qib7 4538 7 35.2 35.2 CD cord-005453-4057qib7 4538 8 % % NN cord-005453-4057qib7 4538 9 ) ) -RRB- cord-005453-4057qib7 4538 10 patients patient NNS cord-005453-4057qib7 4538 11 died die VBD cord-005453-4057qib7 4538 12 comparing compare VBG cord-005453-4057qib7 4538 13 to to IN cord-005453-4057qib7 4538 14 15 15 CD cord-005453-4057qib7 4538 15 ( ( -LRB- cord-005453-4057qib7 4538 16 30.6 30.6 CD cord-005453-4057qib7 4538 17 % % NN cord-005453-4057qib7 4538 18 ) ) -RRB- cord-005453-4057qib7 4538 19 patients patient NNS cord-005453-4057qib7 4538 20 in in IN cord-005453-4057qib7 4538 21 non non JJ cord-005453-4057qib7 4538 22 - - JJ cord-005453-4057qib7 4538 23 malignant malignant JJ cord-005453-4057qib7 4538 24 group group NN cord-005453-4057qib7 4538 25 respectively respectively RB cord-005453-4057qib7 4538 26 . . . cord-005453-4057qib7 4539 1 Main main JJ cord-005453-4057qib7 4539 2 cause cause NN cord-005453-4057qib7 4539 3 of of IN cord-005453-4057qib7 4539 4 death death NN cord-005453-4057qib7 4539 5 in in IN cord-005453-4057qib7 4539 6 analyzed analyze VBN cord-005453-4057qib7 4539 7 group group NN cord-005453-4057qib7 4539 8 of of IN cord-005453-4057qib7 4539 9 infants infant NNS cord-005453-4057qib7 4539 10 was be VBD cord-005453-4057qib7 4539 11 infection infection NN cord-005453-4057qib7 4539 12 ( ( -LRB- cord-005453-4057qib7 4539 13 60 60 CD cord-005453-4057qib7 4539 14 % % NN cord-005453-4057qib7 4539 15 ) ) -RRB- cord-005453-4057qib7 4539 16 . . . cord-005453-4057qib7 4540 1 Conclusions conclusion NNS cord-005453-4057qib7 4540 2 : : : cord-005453-4057qib7 4540 3 1 1 CD cord-005453-4057qib7 4540 4 . . . cord-005453-4057qib7 4541 1 Allo Allo NNP cord-005453-4057qib7 4541 2 - - HYPH cord-005453-4057qib7 4541 3 HSCT HSCT NNP cord-005453-4057qib7 4541 4 is be VBZ cord-005453-4057qib7 4541 5 rarely rarely RB cord-005453-4057qib7 4541 6 performed perform VBN cord-005453-4057qib7 4541 7 in in IN cord-005453-4057qib7 4541 8 children child NNS cord-005453-4057qib7 4541 9 less less JJR cord-005453-4057qib7 4541 10 than than IN cord-005453-4057qib7 4541 11 12 12 CD cord-005453-4057qib7 4541 12 months month NNS cord-005453-4057qib7 4541 13 of of IN cord-005453-4057qib7 4541 14 age age NN cord-005453-4057qib7 4541 15 . . . cord-005453-4057qib7 4542 1 2 2 LS cord-005453-4057qib7 4542 2 . . . cord-005453-4057qib7 4543 1 Majority majority NN cord-005453-4057qib7 4543 2 of of IN cord-005453-4057qib7 4543 3 those those DT cord-005453-4057qib7 4543 4 patients patient NNS cord-005453-4057qib7 4543 5 receive receive VBP cord-005453-4057qib7 4543 6 stem stem NN cord-005453-4057qib7 4543 7 cells cell NNS cord-005453-4057qib7 4543 8 due due JJ cord-005453-4057qib7 4543 9 to to IN cord-005453-4057qib7 4543 10 non non JJ cord-005453-4057qib7 4543 11 - - JJ cord-005453-4057qib7 4543 12 malignant malignant JJ cord-005453-4057qib7 4543 13 disorder disorder NN cord-005453-4057qib7 4543 14 . . . cord-005453-4057qib7 4544 1 3 3 LS cord-005453-4057qib7 4544 2 . . . cord-005453-4057qib7 4545 1 Among among IN cord-005453-4057qib7 4545 2 youngest young JJS cord-005453-4057qib7 4545 3 HSCT HSCT NNP cord-005453-4057qib7 4545 4 recipients recipient NNS cord-005453-4057qib7 4545 5 , , , cord-005453-4057qib7 4545 6 haploidentical haploidentical JJ cord-005453-4057qib7 4545 7 transplant transplant NN cord-005453-4057qib7 4545 8 are be VBP cord-005453-4057qib7 4545 9 more more RBR cord-005453-4057qib7 4545 10 common common JJ cord-005453-4057qib7 4545 11 than than IN cord-005453-4057qib7 4545 12 in in IN cord-005453-4057qib7 4545 13 general general JJ cord-005453-4057qib7 4545 14 pediatric pediatric JJ cord-005453-4057qib7 4545 15 transplant transplant NN cord-005453-4057qib7 4545 16 population population NN cord-005453-4057qib7 4545 17 . . . cord-005453-4057qib7 4546 1 4 4 LS cord-005453-4057qib7 4546 2 . . . cord-005453-4057qib7 4547 1 Graft graft NN cord-005453-4057qib7 4547 2 rejection rejection NN cord-005453-4057qib7 4547 3 is be VBZ cord-005453-4057qib7 4547 4 a a DT cord-005453-4057qib7 4547 5 significant significant JJ cord-005453-4057qib7 4547 6 problem problem NN cord-005453-4057qib7 4547 7 in in IN cord-005453-4057qib7 4547 8 infants infant NNS cord-005453-4057qib7 4547 9 transplanted transplant VBN cord-005453-4057qib7 4547 10 from from IN cord-005453-4057qib7 4547 11 MMRD MMRD NNP cord-005453-4057qib7 4547 12 . . . cord-005453-4057qib7 4548 1 Disclosure disclosure NN cord-005453-4057qib7 4548 2 : : : cord-005453-4057qib7 4548 3 nothing nothing NN cord-005453-4057qib7 4548 4 to to TO cord-005453-4057qib7 4548 5 declare declare VB cord-005453-4057qib7 4548 6 Unusual unusual JJ cord-005453-4057qib7 4548 7 non non JJ cord-005453-4057qib7 4548 8 - - JJ cord-005453-4057qib7 4548 9 infectious infectious JJ cord-005453-4057qib7 4548 10 lung lung NN cord-005453-4057qib7 4548 11 complication complication NN cord-005453-4057qib7 4548 12 after after IN cord-005453-4057qib7 4548 13 allogeneic allogeneic JJ cord-005453-4057qib7 4548 14 haematopoietic haematopoietic JJ cord-005453-4057qib7 4548 15 stem stem NN cord-005453-4057qib7 4548 16 cell cell NN cord-005453-4057qib7 4548 17 transplantation transplantation NN cord-005453-4057qib7 4548 18 Claudia Claudia NNP cord-005453-4057qib7 4548 19 Lucia Lucia NNP cord-005453-4057qib7 4548 20 Sossa Sossa NNP cord-005453-4057qib7 4548 21 Melo Melo NNP cord-005453-4057qib7 4548 22 1,2 1,2 CD cord-005453-4057qib7 4548 23 , , , cord-005453-4057qib7 4548 24 Manuel Manuel NNP cord-005453-4057qib7 4548 25 Rosales Rosales NNP cord-005453-4057qib7 4548 26 2 2 CD cord-005453-4057qib7 4548 27 , , , cord-005453-4057qib7 4549 1 Francisco Francisco NNP cord-005453-4057qib7 4549 2 Fernando Fernando NNP cord-005453-4057qib7 4549 3 Naranjo Naranjo NNP cord-005453-4057qib7 4549 4 Junoy Junoy NNP cord-005453-4057qib7 4549 5 1,2 1,2 CD cord-005453-4057qib7 4549 6 , , , cord-005453-4057qib7 4549 7 Sara Sara NNP cord-005453-4057qib7 4549 8 Inés Inés NNP cord-005453-4057qib7 4549 9 Jiménez Jiménez NNP cord-005453-4057qib7 4549 10 1,2 1,2 CD cord-005453-4057qib7 4549 11 , , , cord-005453-4057qib7 4549 12 Luis Luis NNP cord-005453-4057qib7 4549 13 Antonio Antonio NNP cord-005453-4057qib7 4549 14 Salazar Salazar NNP cord-005453-4057qib7 4549 15 1,2 1,2 CD cord-005453-4057qib7 4549 16 , , , cord-005453-4057qib7 4549 17 Angela Angela NNP cord-005453-4057qib7 4549 18 María María NNP cord-005453-4057qib7 4549 19 Peña Peña NNP cord-005453-4057qib7 4549 20 1,2 1,2 CD cord-005453-4057qib7 4549 21 , , , cord-005453-4057qib7 4549 22 María María NNP cord-005453-4057qib7 4549 23 Angélica Angélica NNP cord-005453-4057qib7 4549 24 Chacón Chacón NNP cord-005453-4057qib7 4549 25 Manosalva Manosalva NNP cord-005453-4057qib7 4549 26 3 3 CD cord-005453-4057qib7 4549 27 , , , cord-005453-4057qib7 4549 28 Maria Maria NNP cord-005453-4057qib7 4549 29 Luna Luna NNP cord-005453-4057qib7 4549 30 - - HYPH cord-005453-4057qib7 4549 31 González González NNP cord-005453-4057qib7 4549 32 1 1 CD cord-005453-4057qib7 4549 33 , , , cord-005453-4057qib7 4549 34 Claudia Claudia NNP cord-005453-4057qib7 4549 35 Marcela Marcela NNP cord-005453-4057qib7 4549 36 Chalela Chalela NNP cord-005453-4057qib7 4549 37 1 1 CD cord-005453-4057qib7 4549 38 , , , cord-005453-4057qib7 4549 39 Manuel Manuel NNP cord-005453-4057qib7 4549 40 Ardila Ardila NNP cord-005453-4057qib7 4549 41 - - HYPH cord-005453-4057qib7 4549 42 Báez Báez NNP cord-005453-4057qib7 4549 43 1 1 CD cord-005453-4057qib7 4549 44 jirovecii jirovecii NNP cord-005453-4057qib7 4549 45 infections infection NNS cord-005453-4057qib7 4549 46 , , , cord-005453-4057qib7 4549 47 viral viral JJ cord-005453-4057qib7 4549 48 infections infection NNS cord-005453-4057qib7 4549 49 or or CC cord-005453-4057qib7 4549 50 Nocardia Nocardia NNP cord-005453-4057qib7 4549 51 . . . cord-005453-4057qib7 4550 1 We -PRON- PRP cord-005453-4057qib7 4550 2 describe describe VBP cord-005453-4057qib7 4550 3 the the DT cord-005453-4057qib7 4550 4 case case NN cord-005453-4057qib7 4550 5 of of IN cord-005453-4057qib7 4550 6 a a DT cord-005453-4057qib7 4550 7 patient patient NN cord-005453-4057qib7 4550 8 with with IN cord-005453-4057qib7 4550 9 Acute acute JJ cord-005453-4057qib7 4550 10 Lymphoblastic Lymphoblastic NNP cord-005453-4057qib7 4550 11 Leukemia Leukemia NNP cord-005453-4057qib7 4550 12 ( ( -LRB- cord-005453-4057qib7 4550 13 ALL all DT cord-005453-4057qib7 4550 14 ) ) -RRB- cord-005453-4057qib7 4550 15 diagnosis diagnosis NN cord-005453-4057qib7 4550 16 with with IN cord-005453-4057qib7 4550 17 PAP pap NN cord-005453-4057qib7 4550 18 associated associate VBN cord-005453-4057qib7 4550 19 to to IN cord-005453-4057qib7 4550 20 a a DT cord-005453-4057qib7 4550 21 HSCT HSCT NNP cord-005453-4057qib7 4550 22 and and CC cord-005453-4057qib7 4550 23 pulmonary pulmonary JJ cord-005453-4057qib7 4550 24 pneumocystis pneumocystis NN cord-005453-4057qib7 4550 25 . . . cord-005453-4057qib7 4551 1 Methods method NNS cord-005453-4057qib7 4551 2 : : : cord-005453-4057qib7 4552 1 A a DT cord-005453-4057qib7 4552 2 55-year 55-year JJ cord-005453-4057qib7 4552 3 - - HYPH cord-005453-4057qib7 4552 4 old old JJ cord-005453-4057qib7 4552 5 Colombian colombian JJ cord-005453-4057qib7 4552 6 female female JJ cord-005453-4057qib7 4552 7 patient patient NN cord-005453-4057qib7 4552 8 diagnosed diagnose VBN cord-005453-4057qib7 4552 9 with with IN cord-005453-4057qib7 4552 10 B b NN cord-005453-4057qib7 4552 11 - - HYPH cord-005453-4057qib7 4552 12 precursor precursor NN cord-005453-4057qib7 4552 13 ALL all DT cord-005453-4057qib7 4552 14 of of IN cord-005453-4057qib7 4552 15 high high JJ cord-005453-4057qib7 4552 16 - - HYPH cord-005453-4057qib7 4552 17 risk risk NN cord-005453-4057qib7 4552 18 in in IN cord-005453-4057qib7 4552 19 January January NNP cord-005453-4057qib7 4552 20 2017 2017 CD cord-005453-4057qib7 4552 21 , , , cord-005453-4057qib7 4552 22 positive positive JJ cord-005453-4057qib7 4552 23 Philadelphia Philadelphia NNP cord-005453-4057qib7 4552 24 chromosome chromosome NN cord-005453-4057qib7 4552 25 , , , cord-005453-4057qib7 4552 26 positive positive JJ cord-005453-4057qib7 4552 27 BCR BCR NNP cord-005453-4057qib7 4552 28 / / SYM cord-005453-4057qib7 4552 29 ABL ABL NNP cord-005453-4057qib7 4552 30 in in IN cord-005453-4057qib7 4552 31 February February NNP cord-005453-4057qib7 4552 32 2017 2017 CD cord-005453-4057qib7 4552 33 , , , cord-005453-4057qib7 4552 34 infiltration infiltration NN cord-005453-4057qib7 4552 35 to to IN cord-005453-4057qib7 4552 36 the the DT cord-005453-4057qib7 4552 37 Central Central NNP cord-005453-4057qib7 4552 38 Nervous Nervous NNP cord-005453-4057qib7 4552 39 System System NNP cord-005453-4057qib7 4552 40 ( ( -LRB- cord-005453-4057qib7 4552 41 CNS CNS NNP cord-005453-4057qib7 4552 42 ) ) -RRB- cord-005453-4057qib7 4552 43 , , , cord-005453-4057qib7 4552 44 2.53 2.53 CD cord-005453-4057qib7 4552 45 % % NN cord-005453-4057qib7 4552 46 of of IN cord-005453-4057qib7 4552 47 lymphoblasts lymphoblast NNS cord-005453-4057qib7 4552 48 , , , cord-005453-4057qib7 4552 49 and and CC cord-005453-4057qib7 4552 50 karyotype karyotype NN cord-005453-4057qib7 4552 51 without without IN cord-005453-4057qib7 4552 52 legible legible JJ cord-005453-4057qib7 4552 53 metaphases metaphase NNS cord-005453-4057qib7 4552 54 . . . cord-005453-4057qib7 4553 1 Refractory refractory JJ cord-005453-4057qib7 4553 2 to to IN cord-005453-4057qib7 4553 3 induction induction NN cord-005453-4057qib7 4553 4 according accord VBG cord-005453-4057qib7 4553 5 to to IN cord-005453-4057qib7 4553 6 the the DT cord-005453-4057qib7 4553 7 PETHEMA PETHEMA NNP cord-005453-4057qib7 4553 8 protocol protocol NN cord-005453-4057qib7 4553 9 ( ( -LRB- cord-005453-4057qib7 4553 10 Vincristine Vincristine NNP cord-005453-4057qib7 4553 11 , , , cord-005453-4057qib7 4553 12 Daunorubicin Daunorubicin NNPS cord-005453-4057qib7 4553 13 , , , cord-005453-4057qib7 4553 14 Prednisone Prednisone NNP cord-005453-4057qib7 4553 15 , , , cord-005453-4057qib7 4553 16 L l NN cord-005453-4057qib7 4553 17 - - HYPH cord-005453-4057qib7 4553 18 asparaginase asparaginase NNP cord-005453-4057qib7 4553 19 ) ) -RRB- cord-005453-4057qib7 4553 20 with with IN cord-005453-4057qib7 4553 21 presence presence NN cord-005453-4057qib7 4553 22 of of IN cord-005453-4057qib7 4553 23 13.9 13.9 CD cord-005453-4057qib7 4553 24 % % NN cord-005453-4057qib7 4553 25 blasts blast NNS cord-005453-4057qib7 4553 26 at at IN cord-005453-4057qib7 4553 27 the the DT cord-005453-4057qib7 4553 28 end end NN cord-005453-4057qib7 4553 29 of of IN cord-005453-4057qib7 4553 30 the the DT cord-005453-4057qib7 4553 31 induction induction NN cord-005453-4057qib7 4553 32 . . . cord-005453-4057qib7 4554 1 Re re NN cord-005453-4057qib7 4554 2 - - NN cord-005453-4057qib7 4554 3 induction induction NN cord-005453-4057qib7 4554 4 was be VBD cord-005453-4057qib7 4554 5 performed perform VBN cord-005453-4057qib7 4554 6 with with IN cord-005453-4057qib7 4554 7 the the DT cord-005453-4057qib7 4554 8 FLAG FLAG NNP cord-005453-4057qib7 4554 9 - - HYPH cord-005453-4057qib7 4554 10 IDA IDA NNP cord-005453-4057qib7 4554 11 protocol protocol NN cord-005453-4057qib7 4554 12 ( ( -LRB- cord-005453-4057qib7 4554 13 Idarubicin Idarubicin NNP cord-005453-4057qib7 4554 14 , , , cord-005453-4057qib7 4554 15 Fludarabine Fludarabine NNP cord-005453-4057qib7 4554 16 , , , cord-005453-4057qib7 4554 17 Cytarabine Cytarabine NNP cord-005453-4057qib7 4554 18 ) ) -RRB- cord-005453-4057qib7 4554 19 achieving achieve VBG cord-005453-4057qib7 4554 20 complete complete JJ cord-005453-4057qib7 4554 21 remission remission NN cord-005453-4057qib7 4554 22 , , , cord-005453-4057qib7 4554 23 obtaining obtain VBG cord-005453-4057qib7 4554 24 Minimum Minimum NNP cord-005453-4057qib7 4554 25 Residual Residual NNP cord-005453-4057qib7 4554 26 Disease Disease NNP cord-005453-4057qib7 4554 27 ( ( -LRB- cord-005453-4057qib7 4554 28 MRD MRD NNP cord-005453-4057qib7 4554 29 ) ) -RRB- cord-005453-4057qib7 4554 30 < < NNP cord-005453-4057qib7 4554 31 0.01 0.01 CD cord-005453-4057qib7 4554 32 . . . cord-005453-4057qib7 4555 1 Dasatinib Dasatinib NNP cord-005453-4057qib7 4555 2 was be VBD cord-005453-4057qib7 4555 3 initiated initiate VBN cord-005453-4057qib7 4555 4 by by IN cord-005453-4057qib7 4555 5 BCR BCR NNP cord-005453-4057qib7 4555 6 / / SYM cord-005453-4057qib7 4555 7 ABL ABL NNP cord-005453-4057qib7 4555 8 expression expression NN cord-005453-4057qib7 4555 9 and and CC cord-005453-4057qib7 4555 10 CNS CNS NNP cord-005453-4057qib7 4555 11 involvement involvement NN cord-005453-4057qib7 4555 12 at at IN cord-005453-4057qib7 4555 13 the the DT cord-005453-4057qib7 4555 14 time time NN cord-005453-4057qib7 4555 15 of of IN cord-005453-4057qib7 4555 16 diagnosis diagnosis NN cord-005453-4057qib7 4555 17 . . . cord-005453-4057qib7 4556 1 An an DT cord-005453-4057qib7 4556 2 allogeneic allogeneic NN cord-005453-4057qib7 4556 3 HSCT HSCT NNP cord-005453-4057qib7 4556 4 was be VBD cord-005453-4057qib7 4556 5 performed perform VBN cord-005453-4057qib7 4556 6 , , , cord-005453-4057qib7 4556 7 from from IN cord-005453-4057qib7 4556 8 a a DT cord-005453-4057qib7 4556 9 male male JJ cord-005453-4057qib7 4556 10 brother brother NN cord-005453-4057qib7 4556 11 donor donor NN cord-005453-4057qib7 4556 12 , , , cord-005453-4057qib7 4556 13 with with IN cord-005453-4057qib7 4556 14 low low JJ cord-005453-4057qib7 4556 15 intensity intensity NN cord-005453-4057qib7 4556 16 conditioning conditioning NN cord-005453-4057qib7 4556 17 TT TT NNP cord-005453-4057qib7 4556 18 BUFLU BUFLU NNP cord-005453-4057qib7 4556 19 and and CC cord-005453-4057qib7 4556 20 prophylaxis prophylaxis NN cord-005453-4057qib7 4556 21 of of IN cord-005453-4057qib7 4556 22 Graft graft NN cord-005453-4057qib7 4556 23 - - HYPH cord-005453-4057qib7 4556 24 versus versus IN cord-005453-4057qib7 4556 25 - - HYPH cord-005453-4057qib7 4556 26 Host host NN cord-005453-4057qib7 4556 27 Disease Disease NNP cord-005453-4057qib7 4556 28 ( ( -LRB- cord-005453-4057qib7 4556 29 GVHD GVHD NNP cord-005453-4057qib7 4556 30 ) ) -RRB- cord-005453-4057qib7 4556 31 with with IN cord-005453-4057qib7 4556 32 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 4556 33 and and CC cord-005453-4057qib7 4556 34 Sirolimus Sirolimus NNP cord-005453-4057qib7 4556 35 . . . cord-005453-4057qib7 4557 1 Patient Patient NNP cord-005453-4057qib7 4557 2 showed show VBD cord-005453-4057qib7 4557 3 early early JJ cord-005453-4057qib7 4557 4 posttransplant posttransplant NN cord-005453-4057qib7 4557 5 complications complication NNS cord-005453-4057qib7 4557 6 , , , cord-005453-4057qib7 4557 7 given give VBN cord-005453-4057qib7 4557 8 the the DT cord-005453-4057qib7 4557 9 reactivation reactivation NN cord-005453-4057qib7 4557 10 of of IN cord-005453-4057qib7 4557 11 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 4557 12 and and CC cord-005453-4057qib7 4557 13 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 4557 14 cystitis cystitis NN cord-005453-4057qib7 4557 15 grade grade NN cord-005453-4057qib7 4557 16 I -PRON- PRP cord-005453-4057qib7 4557 17 due due JJ cord-005453-4057qib7 4557 18 to to IN cord-005453-4057qib7 4557 19 adenovirus adenovirus NN cord-005453-4057qib7 4557 20 . . . cord-005453-4057qib7 4558 1 Late late JJ cord-005453-4057qib7 4558 2 complications complication NNS cord-005453-4057qib7 4558 3 such such JJ cord-005453-4057qib7 4558 4 us -PRON- PRP cord-005453-4057qib7 4558 5 GVHD GVHD NNP cord-005453-4057qib7 4558 6 at at IN cord-005453-4057qib7 4558 7 the the DT cord-005453-4057qib7 4558 8 cutaneous cutaneous JJ cord-005453-4057qib7 4558 9 level level NN cord-005453-4057qib7 4558 10 and and CC cord-005453-4057qib7 4559 1 subsequent subsequent JJ cord-005453-4057qib7 4559 2 hepatic hepatic JJ cord-005453-4057qib7 4559 3 and and CC cord-005453-4057qib7 4559 4 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 4559 5 involvement involvement NN cord-005453-4057qib7 4559 6 were be VBD cord-005453-4057qib7 4559 7 seen see VBN cord-005453-4057qib7 4559 8 too too RB cord-005453-4057qib7 4559 9 , , , cord-005453-4057qib7 4559 10 for for IN cord-005453-4057qib7 4559 11 which which WDT cord-005453-4057qib7 4559 12 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4559 13 therapy therapy NN cord-005453-4057qib7 4559 14 was be VBD cord-005453-4057qib7 4559 15 administered administer VBN cord-005453-4057qib7 4559 16 with with IN cord-005453-4057qib7 4559 17 high high JJ cord-005453-4057qib7 4559 18 doses dose NNS cord-005453-4057qib7 4559 19 of of IN cord-005453-4057qib7 4559 20 systemic systemic JJ cord-005453-4057qib7 4559 21 corticosteroid corticosteroid NN cord-005453-4057qib7 4559 22 . . . cord-005453-4057qib7 4560 1 Results result NNS cord-005453-4057qib7 4560 2 : : : cord-005453-4057qib7 4561 1 Patient Patient NNP cord-005453-4057qib7 4561 2 was be VBD cord-005453-4057qib7 4561 3 hospitalized hospitalize VBN cord-005453-4057qib7 4561 4 on on IN cord-005453-4057qib7 4561 5 day day NN cord-005453-4057qib7 4561 6 +270 +270 NNP cord-005453-4057qib7 4561 7 posttransplantation posttransplantation NN cord-005453-4057qib7 4561 8 due due IN cord-005453-4057qib7 4561 9 to to IN cord-005453-4057qib7 4561 10 febrile febrile JJ cord-005453-4057qib7 4561 11 neutropenia neutropenia NN cord-005453-4057qib7 4561 12 and and CC cord-005453-4057qib7 4561 13 respiratory respiratory JJ cord-005453-4057qib7 4561 14 symptoms symptom NNS cord-005453-4057qib7 4561 15 , , , cord-005453-4057qib7 4561 16 with with IN cord-005453-4057qib7 4561 17 normal normal JJ cord-005453-4057qib7 4561 18 chest chest NN cord-005453-4057qib7 4561 19 CT CT NNP cord-005453-4057qib7 4561 20 , , , cord-005453-4057qib7 4561 21 and and CC cord-005453-4057qib7 4561 22 CT CT NNP cord-005453-4057qib7 4561 23 of of IN cord-005453-4057qib7 4561 24 paranasal paranasal NNP cord-005453-4057qib7 4561 25 sinuses sinus NNS cord-005453-4057qib7 4561 26 with with IN cord-005453-4057qib7 4561 27 acute acute JJ cord-005453-4057qib7 4561 28 pansinusitis pansinusitis NN cord-005453-4057qib7 4561 29 , , , cord-005453-4057qib7 4561 30 for for IN cord-005453-4057qib7 4561 31 which which WDT cord-005453-4057qib7 4561 32 she -PRON- PRP cord-005453-4057qib7 4561 33 received receive VBD cord-005453-4057qib7 4561 34 Meropenem Meropenem NNP cord-005453-4057qib7 4561 35 1gr 1gr NNP cord-005453-4057qib7 4561 36 intravenously intravenously RB cord-005453-4057qib7 4561 37 every every DT cord-005453-4057qib7 4561 38 8 8 CD cord-005453-4057qib7 4561 39 hours hour NNS cord-005453-4057qib7 4561 40 plus plus CC cord-005453-4057qib7 4561 41 Vancomycin Vancomycin NNP cord-005453-4057qib7 4561 42 1gr 1gr NNP cord-005453-4057qib7 4561 43 intravenously intravenously RB cord-005453-4057qib7 4561 44 every every DT cord-005453-4057qib7 4561 45 12 12 CD cord-005453-4057qib7 4561 46 hours hour NNS cord-005453-4057qib7 4561 47 during during IN cord-005453-4057qib7 4561 48 14 14 CD cord-005453-4057qib7 4561 49 days day NNS cord-005453-4057qib7 4561 50 with with IN cord-005453-4057qib7 4561 51 symptom symptom NN cord-005453-4057qib7 4561 52 resolution resolution NN cord-005453-4057qib7 4561 53 . . . cord-005453-4057qib7 4562 1 She -PRON- PRP cord-005453-4057qib7 4562 2 remained remain VBD cord-005453-4057qib7 4562 3 hospitalized hospitalize VBN cord-005453-4057qib7 4562 4 for for IN cord-005453-4057qib7 4562 5 cytopenias cytopenia NNS cord-005453-4057qib7 4562 6 with with IN cord-005453-4057qib7 4562 7 normal normal JJ cord-005453-4057qib7 4562 8 bone bone NN cord-005453-4057qib7 4562 9 marrow marrow NN cord-005453-4057qib7 4562 10 and and CC cord-005453-4057qib7 4562 11 100 100 CD cord-005453-4057qib7 4562 12 % % NN cord-005453-4057qib7 4562 13 chimerism chimerism NN cord-005453-4057qib7 4562 14 . . . cord-005453-4057qib7 4563 1 On on IN cord-005453-4057qib7 4563 2 day day NN cord-005453-4057qib7 4563 3 +291 +291 NNP cord-005453-4057qib7 4563 4 posttransplant posttransplant NNP cord-005453-4057qib7 4563 5 she -PRON- PRP cord-005453-4057qib7 4563 6 presented present VBD cord-005453-4057qib7 4563 7 fever fever NN cord-005453-4057qib7 4563 8 and and CC cord-005453-4057qib7 4563 9 leukocytosis leukocytosis NN cord-005453-4057qib7 4563 10 , , , cord-005453-4057qib7 4563 11 with with IN cord-005453-4057qib7 4563 12 acute acute JJ cord-005453-4057qib7 4563 13 respiratory respiratory JJ cord-005453-4057qib7 4563 14 failure failure NN cord-005453-4057qib7 4563 15 with with IN cord-005453-4057qib7 4563 16 chest chest NN cord-005453-4057qib7 4563 17 CT CT NNP cord-005453-4057qib7 4563 18 that that WDT cord-005453-4057qib7 4563 19 showed show VBD cord-005453-4057qib7 4563 20 bilateral bilateral JJ cord-005453-4057qib7 4563 21 alveolar alveolar JJ cord-005453-4057qib7 4563 22 occupation occupation NN cord-005453-4057qib7 4563 23 , , , cord-005453-4057qib7 4563 24 " " `` cord-005453-4057qib7 4563 25 crazy crazy JJ cord-005453-4057qib7 4563 26 - - HYPH cord-005453-4057qib7 4563 27 paving pave VBG cord-005453-4057qib7 4563 28 " " '' cord-005453-4057qib7 4563 29 pattern pattern NN cord-005453-4057qib7 4563 30 and and CC cord-005453-4057qib7 4563 31 frosted frosted JJ cord-005453-4057qib7 4563 32 glass glass NN cord-005453-4057qib7 4563 33 ( ( -LRB- cord-005453-4057qib7 4563 34 see see VB cord-005453-4057qib7 4563 35 image image NN cord-005453-4057qib7 4563 36 ) ) -RRB- cord-005453-4057qib7 4563 37 , , , cord-005453-4057qib7 4563 38 so so IN cord-005453-4057qib7 4563 39 diagnostic diagnostic JJ cord-005453-4057qib7 4563 40 fibro fibro NN cord-005453-4057qib7 4563 41 - - HYPH cord-005453-4057qib7 4563 42 bronchoscopy bronchoscopy NN cord-005453-4057qib7 4563 43 was be VBD cord-005453-4057qib7 4563 44 performed perform VBN cord-005453-4057qib7 4563 45 , , , cord-005453-4057qib7 4563 46 reporting report VBG cord-005453-4057qib7 4563 47 postoperatively postoperatively RB cord-005453-4057qib7 4563 48 for for IN cord-005453-4057qib7 4563 49 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 4563 50 jirovecii jirovecii NNP cord-005453-4057qib7 4563 51 . . . cord-005453-4057qib7 4564 1 She -PRON- PRP cord-005453-4057qib7 4564 2 received receive VBD cord-005453-4057qib7 4564 3 21 21 CD cord-005453-4057qib7 4564 4 days day NNS cord-005453-4057qib7 4564 5 of of IN cord-005453-4057qib7 4564 6 Trimethoprim Trimethoprim NNP cord-005453-4057qib7 4564 7 - - HYPH cord-005453-4057qib7 4564 8 sulfamethoxazole sulfamethoxazole NNP cord-005453-4057qib7 4564 9 , , , cord-005453-4057qib7 4564 10 with with IN cord-005453-4057qib7 4564 11 a a DT cord-005453-4057qib7 4564 12 torpid torpid JJ cord-005453-4057qib7 4564 13 evolution evolution NN cord-005453-4057qib7 4564 14 requiring require VBG cord-005453-4057qib7 4564 15 mechanical mechanical JJ cord-005453-4057qib7 4564 16 ventilation ventilation NN cord-005453-4057qib7 4564 17 and and CC cord-005453-4057qib7 4564 18 tracheostomy tracheostomy NN cord-005453-4057qib7 4564 19 , , , cord-005453-4057qib7 4564 20 persisting persist VBG cord-005453-4057qib7 4564 21 with with IN cord-005453-4057qib7 4564 22 hypoxemia hypoxemia NN cord-005453-4057qib7 4564 23 . . . cord-005453-4057qib7 4565 1 The the DT cord-005453-4057qib7 4565 2 report report NN cord-005453-4057qib7 4565 3 of of IN cord-005453-4057qib7 4565 4 cultures culture NNS cord-005453-4057qib7 4565 5 for for IN cord-005453-4057qib7 4565 6 fungi fungus NNS cord-005453-4057qib7 4565 7 , , , cord-005453-4057qib7 4565 8 mycobacteria mycobacterium NNS cord-005453-4057qib7 4565 9 , , , cord-005453-4057qib7 4565 10 and and CC cord-005453-4057qib7 4565 11 respiratory respiratory JJ cord-005453-4057qib7 4565 12 panel panel NN cord-005453-4057qib7 4565 13 of of IN cord-005453-4057qib7 4565 14 FilmArray FilmArray NNP cord-005453-4057qib7 4565 15 were be VBD cord-005453-4057qib7 4565 16 negative negative JJ cord-005453-4057qib7 4565 17 . . . cord-005453-4057qib7 4566 1 A a DT cord-005453-4057qib7 4566 2 pathology pathology NN cord-005453-4057qib7 4566 3 report report NN cord-005453-4057qib7 4566 4 was be VBD cord-005453-4057qib7 4566 5 obtained obtain VBN cord-005453-4057qib7 4566 6 with with IN cord-005453-4057qib7 4566 7 30 30 CD cord-005453-4057qib7 4566 8 % % NN cord-005453-4057qib7 4566 9 neutrophils neutrophil NNS cord-005453-4057qib7 4566 10 , , , cord-005453-4057qib7 4566 11 as as RB cord-005453-4057qib7 4566 12 well well RB cord-005453-4057qib7 4566 13 as as IN cord-005453-4057qib7 4566 14 PAS pas NN cord-005453-4057qib7 4566 15 staining stain VBG cord-005453-4057qib7 4566 16 with with IN cord-005453-4057qib7 4566 17 acellular acellular JJ cord-005453-4057qib7 4566 18 pink pink JJ cord-005453-4057qib7 4566 19 material material NN cord-005453-4057qib7 4566 20 and and CC cord-005453-4057qib7 4566 21 elevated elevated JJ cord-005453-4057qib7 4566 22 serum serum NN cord-005453-4057qib7 4566 23 LDH LDH NNP cord-005453-4057qib7 4566 24 , , , cord-005453-4057qib7 4566 25 with with IN cord-005453-4057qib7 4566 26 a a DT cord-005453-4057qib7 4566 27 diagnosis diagnosis NN cord-005453-4057qib7 4566 28 of of IN cord-005453-4057qib7 4566 29 secondary secondary JJ cord-005453-4057qib7 4566 30 PAP pap NN cord-005453-4057qib7 4566 31 . . . cord-005453-4057qib7 4567 1 The the DT cord-005453-4057qib7 4567 2 patient patient NN cord-005453-4057qib7 4567 3 continued continue VBD cord-005453-4057qib7 4567 4 with with IN cord-005453-4057qib7 4567 5 poor poor JJ cord-005453-4057qib7 4567 6 general general JJ cord-005453-4057qib7 4567 7 condition condition NN cord-005453-4057qib7 4567 8 , , , cord-005453-4057qib7 4567 9 refractory refractory JJ cord-005453-4057qib7 4567 10 hypoxemia hypoxemia NN cord-005453-4057qib7 4567 11 , , , cord-005453-4057qib7 4567 12 high high JJ cord-005453-4057qib7 4567 13 ventilatory ventilatory NN cord-005453-4057qib7 4567 14 parameters parameter NNS cord-005453-4057qib7 4567 15 and and CC cord-005453-4057qib7 4567 16 hemodynamic hemodynamic JJ cord-005453-4057qib7 4567 17 instability instability NN cord-005453-4057qib7 4567 18 , , , cord-005453-4057qib7 4567 19 due due IN cord-005453-4057qib7 4567 20 to to IN cord-005453-4057qib7 4567 21 which which WDT cord-005453-4057qib7 4567 22 she -PRON- PRP cord-005453-4057qib7 4567 23 was be VBD cord-005453-4057qib7 4567 24 not not RB cord-005453-4057qib7 4567 25 able able JJ cord-005453-4057qib7 4567 26 to to TO cord-005453-4057qib7 4567 27 be be VB cord-005453-4057qib7 4567 28 a a DT cord-005453-4057qib7 4567 29 candidate candidate NN cord-005453-4057qib7 4567 30 for for IN cord-005453-4057qib7 4567 31 treatment treatment NN cord-005453-4057qib7 4567 32 with with IN cord-005453-4057qib7 4567 33 total total JJ cord-005453-4057qib7 4567 34 pulmonary pulmonary JJ cord-005453-4057qib7 4567 35 lavage lavage NN cord-005453-4057qib7 4567 36 ; ; : cord-005453-4057qib7 4567 37 leading lead VBG cord-005453-4057qib7 4567 38 to to IN cord-005453-4057qib7 4567 39 multi multi JJ cord-005453-4057qib7 4567 40 - - JJ cord-005453-4057qib7 4567 41 organ organ JJ cord-005453-4057qib7 4567 42 failure failure NN cord-005453-4057qib7 4567 43 and and CC cord-005453-4057qib7 4567 44 later later RB cord-005453-4057qib7 4567 45 death death NN cord-005453-4057qib7 4567 46 . . . cord-005453-4057qib7 4568 1 [ [ -LRB- cord-005453-4057qib7 4568 2 [ [ -LRB- cord-005453-4057qib7 4568 3 P211 p211 CD cord-005453-4057qib7 4568 4 Image image NN cord-005453-4057qib7 4568 5 ] ] -RRB- cord-005453-4057qib7 4568 6 1 1 CD cord-005453-4057qib7 4568 7 . . . cord-005453-4057qib7 4569 1 High high JJ cord-005453-4057qib7 4569 2 resolution resolution NN cord-005453-4057qib7 4569 3 chest chest NN cord-005453-4057qib7 4569 4 CT CT NNP cord-005453-4057qib7 4569 5 . . . cord-005453-4057qib7 4570 1 Sample sample JJ cord-005453-4057qib7 4570 2 opacification opacification NN cord-005453-4057qib7 4570 3 in in IN cord-005453-4057qib7 4570 4 frosted frosted JJ cord-005453-4057qib7 4570 5 glass glass NN cord-005453-4057qib7 4570 6 ( ( -LRB- cord-005453-4057qib7 4570 7 A a NN cord-005453-4057qib7 4570 8 ) ) -RRB- cord-005453-4057qib7 4570 9 and and CC cord-005453-4057qib7 4570 10 pattern pattern NN cord-005453-4057qib7 4570 11 ' ' '' cord-005453-4057qib7 4570 12 ' ' '' cord-005453-4057qib7 4570 13 Crazypaving Crazypaving NNP cord-005453-4057qib7 4570 14 ' ' '' cord-005453-4057qib7 4570 15 ' ' '' cord-005453-4057qib7 4570 16 ( ( -LRB- cord-005453-4057qib7 4570 17 B b NN cord-005453-4057qib7 4570 18 ) ) -RRB- cord-005453-4057qib7 4570 19 ] ] -RRB- cord-005453-4057qib7 4571 1 Conclusions conclusion NNS cord-005453-4057qib7 4571 2 : : : cord-005453-4057qib7 4572 1 The the DT cord-005453-4057qib7 4572 2 importance importance NN cord-005453-4057qib7 4572 3 of of IN cord-005453-4057qib7 4572 4 considering consider VBG cord-005453-4057qib7 4572 5 the the DT cord-005453-4057qib7 4572 6 diagnosis diagnosis NN cord-005453-4057qib7 4572 7 of of IN cord-005453-4057qib7 4572 8 PAP pap NN cord-005453-4057qib7 4572 9 as as IN cord-005453-4057qib7 4572 10 a a DT cord-005453-4057qib7 4572 11 noninfectious noninfectious JJ cord-005453-4057qib7 4572 12 pulmonary pulmonary JJ cord-005453-4057qib7 4572 13 complication complication NN cord-005453-4057qib7 4572 14 in in IN cord-005453-4057qib7 4572 15 patients patient NNS cord-005453-4057qib7 4572 16 with with IN cord-005453-4057qib7 4572 17 allogenic allogenic JJ cord-005453-4057qib7 4572 18 HSCT HSCT NNP cord-005453-4057qib7 4572 19 despite despite IN cord-005453-4057qib7 4572 20 its -PRON- PRP$ cord-005453-4057qib7 4572 21 low low JJ cord-005453-4057qib7 4572 22 incidence incidence NN cord-005453-4057qib7 4572 23 is be VBZ cord-005453-4057qib7 4572 24 recognized recognize VBN cord-005453-4057qib7 4572 25 . . . cord-005453-4057qib7 4573 1 Disclosure disclosure NN cord-005453-4057qib7 4573 2 : : : cord-005453-4057qib7 4573 3 Nothing nothing NN cord-005453-4057qib7 4573 4 to to TO cord-005453-4057qib7 4573 5 declare declare VB cord-005453-4057qib7 4573 6 Methods method NNS cord-005453-4057qib7 4573 7 : : : cord-005453-4057qib7 4573 8 Once once IN cord-005453-4057qib7 4573 9 the the DT cord-005453-4057qib7 4573 10 project project NN cord-005453-4057qib7 4573 11 was be VBD cord-005453-4057qib7 4573 12 approved approve VBN cord-005453-4057qib7 4573 13 by by IN cord-005453-4057qib7 4573 14 the the DT cord-005453-4057qib7 4573 15 Clinical Clinical NNP cord-005453-4057qib7 4573 16 Trials Trials NNPS cord-005453-4057qib7 4573 17 and and CC cord-005453-4057qib7 4573 18 Ethics Ethics NNP cord-005453-4057qib7 4573 19 Committee Committee NNP cord-005453-4057qib7 4573 20 , , , cord-005453-4057qib7 4573 21 154 154 CD cord-005453-4057qib7 4573 22 pairs pair NNS cord-005453-4057qib7 4573 23 of of IN cord-005453-4057qib7 4573 24 blood blood NN cord-005453-4057qib7 4573 25 samples sample NNS cord-005453-4057qib7 4573 26 were be VBD cord-005453-4057qib7 4573 27 drawn draw VBN cord-005453-4057qib7 4573 28 ( ( -LRB- cord-005453-4057qib7 4573 29 154 154 CD cord-005453-4057qib7 4573 30 from from IN cord-005453-4057qib7 4573 31 PICC PICC NNP cord-005453-4057qib7 4573 32 line line NN cord-005453-4057qib7 4573 33 and and CC cord-005453-4057qib7 4573 34 154 154 CD cord-005453-4057qib7 4573 35 from from IN cord-005453-4057qib7 4573 36 venepuncture venepuncture NN cord-005453-4057qib7 4573 37 ) ) -RRB- cord-005453-4057qib7 4573 38 from from IN cord-005453-4057qib7 4573 39 33 33 CD cord-005453-4057qib7 4573 40 voluntary voluntary JJ cord-005453-4057qib7 4573 41 allo allo NN cord-005453-4057qib7 4573 42 - - HYPH cord-005453-4057qib7 4573 43 HSCT HSCT NNP cord-005453-4057qib7 4573 44 recipients recipient NNS cord-005453-4057qib7 4573 45 who who WP cord-005453-4057qib7 4573 46 were be VBD cord-005453-4057qib7 4573 47 receiving receive VBG cord-005453-4057qib7 4573 48 continuous continuous JJ cord-005453-4057qib7 4573 49 infusion infusion NN cord-005453-4057qib7 4573 50 tacrolimus tacrolimus NN cord-005453-4057qib7 4573 51 from from IN cord-005453-4057qib7 4573 52 February February NNP cord-005453-4057qib7 4573 53 through through IN cord-005453-4057qib7 4573 54 August August NNP cord-005453-4057qib7 4573 55 2018 2018 CD cord-005453-4057qib7 4573 56 . . . cord-005453-4057qib7 4574 1 The the DT cord-005453-4057qib7 4574 2 pts pts NN cord-005453-4057qib7 4574 3 had have VBD cord-005453-4057qib7 4574 4 inserted insert VBN cord-005453-4057qib7 4574 5 a a DT cord-005453-4057qib7 4574 6 double double JJ cord-005453-4057qib7 4574 7 - - HYPH cord-005453-4057qib7 4574 8 lumen lumen NN cord-005453-4057qib7 4574 9 polyurethane polyurethane NN cord-005453-4057qib7 4574 10 PICC PICC NNP cord-005453-4057qib7 4574 11 . . . cord-005453-4057qib7 4575 1 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 4575 2 was be VBD cord-005453-4057qib7 4575 3 always always RB cord-005453-4057qib7 4575 4 administered administer VBN cord-005453-4057qib7 4575 5 through through IN cord-005453-4057qib7 4575 6 the the DT cord-005453-4057qib7 4575 7 red red JJ cord-005453-4057qib7 4575 8 line line NN cord-005453-4057qib7 4575 9 , , , cord-005453-4057qib7 4575 10 and and CC cord-005453-4057qib7 4575 11 the the DT cord-005453-4057qib7 4575 12 blood blood NN cord-005453-4057qib7 4575 13 draw draw VBP cord-005453-4057qib7 4575 14 always always RB cord-005453-4057qib7 4575 15 performed perform VBN cord-005453-4057qib7 4575 16 through through IN cord-005453-4057qib7 4575 17 the the DT cord-005453-4057qib7 4575 18 purple purple JJ cord-005453-4057qib7 4575 19 line line NN cord-005453-4057qib7 4575 20 . . . cord-005453-4057qib7 4576 1 All all DT cord-005453-4057qib7 4576 2 of of IN cord-005453-4057qib7 4576 3 the the DT cord-005453-4057qib7 4576 4 patients patient NNS cord-005453-4057qib7 4576 5 signed sign VBD cord-005453-4057qib7 4576 6 the the DT cord-005453-4057qib7 4576 7 informed informed JJ cord-005453-4057qib7 4576 8 consent consent NN cord-005453-4057qib7 4576 9 . . . cord-005453-4057qib7 4577 1 22 22 CD cord-005453-4057qib7 4577 2 were be VBD cord-005453-4057qib7 4577 3 male male JJ cord-005453-4057qib7 4577 4 and and CC cord-005453-4057qib7 4577 5 11 11 CD cord-005453-4057qib7 4577 6 women woman NNS cord-005453-4057qib7 4577 7 . . . cord-005453-4057qib7 4578 1 Median median JJ cord-005453-4057qib7 4578 2 age age NN cord-005453-4057qib7 4578 3 was be VBD cord-005453-4057qib7 4578 4 55 55 CD cord-005453-4057qib7 4578 5 years year NNS cord-005453-4057qib7 4578 6 ( ( -LRB- cord-005453-4057qib7 4578 7 30 30 CD cord-005453-4057qib7 4578 8 - - SYM cord-005453-4057qib7 4578 9 68 68 CD cord-005453-4057qib7 4578 10 ) ) -RRB- cord-005453-4057qib7 4578 11 . . . cord-005453-4057qib7 4579 1 24 24 CD cord-005453-4057qib7 4579 2 of of IN cord-005453-4057qib7 4579 3 the the DT cord-005453-4057qib7 4579 4 venepunctures venepuncture NNS cord-005453-4057qib7 4579 5 were be VBD cord-005453-4057qib7 4579 6 carried carry VBN cord-005453-4057qib7 4579 7 out out RP cord-005453-4057qib7 4579 8 in in IN cord-005453-4057qib7 4579 9 the the DT cord-005453-4057qib7 4579 10 arm arm NN cord-005453-4057qib7 4579 11 where where WRB cord-005453-4057qib7 4579 12 the the DT cord-005453-4057qib7 4579 13 PICC PICC NNP cord-005453-4057qib7 4579 14 was be VBD cord-005453-4057qib7 4579 15 set set VBN cord-005453-4057qib7 4579 16 , , , cord-005453-4057qib7 4579 17 and and CC cord-005453-4057qib7 4579 18 the the DT cord-005453-4057qib7 4579 19 other other JJ cord-005453-4057qib7 4579 20 130 130 CD cord-005453-4057qib7 4579 21 from from IN cord-005453-4057qib7 4579 22 the the DT cord-005453-4057qib7 4579 23 contralateral contralateral JJ cord-005453-4057qib7 4579 24 arm arm NN cord-005453-4057qib7 4579 25 . . . cord-005453-4057qib7 4580 1 A a DT cord-005453-4057qib7 4580 2 limited limited JJ cord-005453-4057qib7 4580 3 group group NN cord-005453-4057qib7 4580 4 of of IN cord-005453-4057qib7 4580 5 nurses nurse NNS cord-005453-4057qib7 4580 6 performed perform VBD cord-005453-4057qib7 4580 7 the the DT cord-005453-4057qib7 4580 8 extractions extraction NNS cord-005453-4057qib7 4580 9 of of IN cord-005453-4057qib7 4580 10 the the DT cord-005453-4057qib7 4580 11 samples sample NNS cord-005453-4057qib7 4580 12 . . . cord-005453-4057qib7 4581 1 Results result NNS cord-005453-4057qib7 4581 2 : : : cord-005453-4057qib7 4582 1 As as IN cord-005453-4057qib7 4582 2 shown show VBN cord-005453-4057qib7 4582 3 in in IN cord-005453-4057qib7 4582 4 the the DT cord-005453-4057qib7 4582 5 table table NN cord-005453-4057qib7 4582 6 , , , cord-005453-4057qib7 4582 7 tacrolimus tacrolimus RB cord-005453-4057qib7 4582 8 trough trough NN cord-005453-4057qib7 4582 9 levels level NNS cord-005453-4057qib7 4582 10 determined determine VBN cord-005453-4057qib7 4582 11 in in IN cord-005453-4057qib7 4582 12 blood blood NN cord-005453-4057qib7 4582 13 from from IN cord-005453-4057qib7 4582 14 venepuncture venepuncture NN cord-005453-4057qib7 4582 15 were be VBD cord-005453-4057qib7 4582 16 similar similar JJ cord-005453-4057qib7 4582 17 to to IN cord-005453-4057qib7 4582 18 those those DT cord-005453-4057qib7 4582 19 in in IN cord-005453-4057qib7 4582 20 blood blood NN cord-005453-4057qib7 4582 21 drawn draw VBN cord-005453-4057qib7 4582 22 through through IN cord-005453-4057qib7 4582 23 the the DT cord-005453-4057qib7 4582 24 PICC PICC NNP cord-005453-4057qib7 4582 25 ( ( -LRB- cord-005453-4057qib7 4582 26 median median NN cord-005453-4057qib7 4582 27 : : : cord-005453-4057qib7 4582 28 10.7 10.7 CD cord-005453-4057qib7 4582 29 vs vs IN cord-005453-4057qib7 4582 30 11.1 11.1 CD cord-005453-4057qib7 4582 31 ng ng NNP cord-005453-4057qib7 4582 32 / / SYM cord-005453-4057qib7 4582 33 mL mL NNP cord-005453-4057qib7 4582 34 ) ) -RRB- cord-005453-4057qib7 4582 35 . . . cord-005453-4057qib7 4583 1 When when WRB cord-005453-4057qib7 4583 2 comparing compare VBG cord-005453-4057qib7 4583 3 one one CD cord-005453-4057qib7 4583 4 by by IN cord-005453-4057qib7 4583 5 one one CD cord-005453-4057qib7 4583 6 in in IN cord-005453-4057qib7 4583 7 the the DT cord-005453-4057qib7 4583 8 individual individual JJ cord-005453-4057qib7 4583 9 patients patient NNS cord-005453-4057qib7 4583 10 , , , cord-005453-4057qib7 4583 11 the the DT cord-005453-4057qib7 4583 12 differences difference NNS cord-005453-4057qib7 4583 13 were be VBD cord-005453-4057qib7 4583 14 not not RB cord-005453-4057qib7 4583 15 significant significant JJ cord-005453-4057qib7 4583 16 , , , cord-005453-4057qib7 4583 17 and and CC cord-005453-4057qib7 4583 18 changed change VBD cord-005453-4057qib7 4583 19 the the DT cord-005453-4057qib7 4583 20 dosing dosing NN cord-005453-4057qib7 4583 21 prescription prescription NN cord-005453-4057qib7 4583 22 in in IN cord-005453-4057qib7 4583 23 no no DT cord-005453-4057qib7 4583 24 cases case NNS cord-005453-4057qib7 4583 25 . . . cord-005453-4057qib7 4584 1 Conclusions conclusion NNS cord-005453-4057qib7 4584 2 : : : cord-005453-4057qib7 4585 1 In in IN cord-005453-4057qib7 4585 2 our -PRON- PRP$ cord-005453-4057qib7 4585 3 experience experience NN cord-005453-4057qib7 4585 4 , , , cord-005453-4057qib7 4585 5 there there EX cord-005453-4057qib7 4585 6 are be VBP cord-005453-4057qib7 4585 7 not not RB cord-005453-4057qib7 4585 8 significant significant JJ cord-005453-4057qib7 4585 9 differences difference NNS cord-005453-4057qib7 4585 10 in in IN cord-005453-4057qib7 4585 11 tacrolimus tacrolimus NN cord-005453-4057qib7 4585 12 levels level NNS cord-005453-4057qib7 4585 13 draw draw VBP cord-005453-4057qib7 4585 14 from from IN cord-005453-4057qib7 4585 15 the the DT cord-005453-4057qib7 4585 16 PICC PICC NNP cord-005453-4057qib7 4585 17 line line NN cord-005453-4057qib7 4585 18 , , , cord-005453-4057qib7 4585 19 compared compare VBN cord-005453-4057qib7 4585 20 with with IN cord-005453-4057qib7 4585 21 a a DT cord-005453-4057qib7 4585 22 peripheral peripheral JJ cord-005453-4057qib7 4585 23 site site NN cord-005453-4057qib7 4585 24 . . . cord-005453-4057qib7 4586 1 So so RB cord-005453-4057qib7 4586 2 , , , cord-005453-4057qib7 4586 3 in in IN cord-005453-4057qib7 4586 4 our -PRON- PRP$ cord-005453-4057qib7 4586 5 opinion opinion NN cord-005453-4057qib7 4586 6 , , , cord-005453-4057qib7 4586 7 if if IN cord-005453-4057qib7 4586 8 the the DT cord-005453-4057qib7 4586 9 line line NN cord-005453-4057qib7 4586 10 for for IN cord-005453-4057qib7 4586 11 tacrolimus tacrolimus NN cord-005453-4057qib7 4586 12 infusion infusion NN cord-005453-4057qib7 4586 13 is be VBZ cord-005453-4057qib7 4586 14 properly properly RB cord-005453-4057qib7 4586 15 identified identify VBN cord-005453-4057qib7 4586 16 and and CC cord-005453-4057qib7 4586 17 the the DT cord-005453-4057qib7 4586 18 one one NN cord-005453-4057qib7 4586 19 used use VBN cord-005453-4057qib7 4586 20 for for IN cord-005453-4057qib7 4586 21 the the DT cord-005453-4057qib7 4586 22 sample sample NN cord-005453-4057qib7 4586 23 draw draw NN cord-005453-4057qib7 4586 24 is be VBZ cord-005453-4057qib7 4586 25 the the DT cord-005453-4057qib7 4586 26 alternative alternative JJ cord-005453-4057qib7 4586 27 one one NN cord-005453-4057qib7 4586 28 , , , cord-005453-4057qib7 4586 29 venepunctures venepuncture VBZ cord-005453-4057qib7 4586 30 to to TO cord-005453-4057qib7 4586 31 obtain obtain VB cord-005453-4057qib7 4586 32 sample sample NN cord-005453-4057qib7 4586 33 from from IN cord-005453-4057qib7 4586 34 peripheral peripheral JJ cord-005453-4057qib7 4586 35 sites site NNS cord-005453-4057qib7 4586 36 are be VBP cord-005453-4057qib7 4586 37 not not RB cord-005453-4057qib7 4586 38 justified justified JJ cord-005453-4057qib7 4586 39 for for IN cord-005453-4057qib7 4586 40 tacrolimus tacrolimus NN cord-005453-4057qib7 4586 41 levels level NNS cord-005453-4057qib7 4586 42 measurements measurement NNS cord-005453-4057qib7 4586 43 . . . cord-005453-4057qib7 4587 1 Background background NN cord-005453-4057qib7 4587 2 : : : cord-005453-4057qib7 4588 1 Patients patient NNS cord-005453-4057qib7 4588 2 undergoing undergo VBG cord-005453-4057qib7 4588 3 a a DT cord-005453-4057qib7 4588 4 HSCT HSCT NNP cord-005453-4057qib7 4588 5 may may MD cord-005453-4057qib7 4588 6 require require VB cord-005453-4057qib7 4588 7 ICU ICU NNP cord-005453-4057qib7 4588 8 admission admission NN cord-005453-4057qib7 4588 9 due due IN cord-005453-4057qib7 4588 10 to to IN cord-005453-4057qib7 4588 11 transplant transplant NN cord-005453-4057qib7 4588 12 - - HYPH cord-005453-4057qib7 4588 13 related relate VBN cord-005453-4057qib7 4588 14 toxicities toxicity NNS cord-005453-4057qib7 4588 15 . . . cord-005453-4057qib7 4589 1 The the DT cord-005453-4057qib7 4589 2 aim aim NN cord-005453-4057qib7 4589 3 of of IN cord-005453-4057qib7 4589 4 this this DT cord-005453-4057qib7 4589 5 study study NN cord-005453-4057qib7 4589 6 was be VBD cord-005453-4057qib7 4589 7 to to TO cord-005453-4057qib7 4589 8 analyse analyse VB cord-005453-4057qib7 4589 9 a a DT cord-005453-4057qib7 4589 10 single single JJ cord-005453-4057qib7 4589 11 centre centre NN cord-005453-4057qib7 4589 12 experience experience NN cord-005453-4057qib7 4589 13 with with IN cord-005453-4057qib7 4589 14 HSCT HSCT NNP cord-005453-4057qib7 4589 15 patients patient NNS cord-005453-4057qib7 4589 16 requiring require VBG cord-005453-4057qib7 4589 17 ICU ICU NNP cord-005453-4057qib7 4589 18 admission admission NN cord-005453-4057qib7 4589 19 and and CC cord-005453-4057qib7 4589 20 the the DT cord-005453-4057qib7 4589 21 factors factor NNS cord-005453-4057qib7 4589 22 affecting affect VBG cord-005453-4057qib7 4589 23 outcome outcome NN cord-005453-4057qib7 4589 24 . . . cord-005453-4057qib7 4590 1 Methods method NNS cord-005453-4057qib7 4590 2 : : : cord-005453-4057qib7 4590 3 We -PRON- PRP cord-005453-4057qib7 4590 4 included include VBD cord-005453-4057qib7 4590 5 all all DT cord-005453-4057qib7 4590 6 adult adult NN cord-005453-4057qib7 4590 7 patients patient NNS cord-005453-4057qib7 4590 8 ( ( -LRB- cord-005453-4057qib7 4590 9 age age NN cord-005453-4057qib7 4590 10 > > XX cord-005453-4057qib7 4590 11 = = SYM cord-005453-4057qib7 4590 12 18 18 CD cord-005453-4057qib7 4590 13 ) ) -RRB- cord-005453-4057qib7 4590 14 who who WP cord-005453-4057qib7 4590 15 had have VBD cord-005453-4057qib7 4590 16 an an DT cord-005453-4057qib7 4590 17 allogeneic allogeneic NN cord-005453-4057qib7 4590 18 or or CC cord-005453-4057qib7 4590 19 autologous autologous JJ cord-005453-4057qib7 4590 20 HSCT HSCT NNP cord-005453-4057qib7 4590 21 during during IN cord-005453-4057qib7 4590 22 2017 2017 CD cord-005453-4057qib7 4591 1 ( ( -LRB- cord-005453-4057qib7 4591 2 D0 d0 NN cord-005453-4057qib7 4591 3 between between IN cord-005453-4057qib7 4591 4 1 1 CD cord-005453-4057qib7 4591 5 - - HYPH cord-005453-4057qib7 4591 6 1 1 CD cord-005453-4057qib7 4591 7 - - HYPH cord-005453-4057qib7 4591 8 2017 2017 CD cord-005453-4057qib7 4591 9 to to IN cord-005453-4057qib7 4591 10 31 31 CD cord-005453-4057qib7 4591 11 - - HYPH cord-005453-4057qib7 4591 12 12 12 CD cord-005453-4057qib7 4591 13 - - HYPH cord-005453-4057qib7 4591 14 2017 2017 CD cord-005453-4057qib7 4591 15 ) ) -RRB- cord-005453-4057qib7 4591 16 at at IN cord-005453-4057qib7 4591 17 St. St. NNP cord-005453-4057qib7 4591 18 George George NNP cord-005453-4057qib7 4591 19 's 's POS cord-005453-4057qib7 4591 20 Hospital Hospital NNP cord-005453-4057qib7 4591 21 . . . cord-005453-4057qib7 4592 1 Data datum NNS cord-005453-4057qib7 4592 2 was be VBD cord-005453-4057qib7 4592 3 retrospectively retrospectively RB cord-005453-4057qib7 4592 4 collected collect VBN cord-005453-4057qib7 4592 5 from from IN cord-005453-4057qib7 4592 6 patients patient NNS cord-005453-4057qib7 4592 7 ' ' POS cord-005453-4057qib7 4592 8 notes note NNS cord-005453-4057qib7 4592 9 . . . cord-005453-4057qib7 4593 1 ICU ICU NNP cord-005453-4057qib7 4593 2 outcome outcome NN cord-005453-4057qib7 4593 3 and and CC cord-005453-4057qib7 4593 4 100-day 100-day JJ cord-005453-4057qib7 4593 5 survival survival NN cord-005453-4057qib7 4593 6 were be VBD cord-005453-4057qib7 4593 7 analysed analyse VBN cord-005453-4057qib7 4593 8 . . . cord-005453-4057qib7 4594 1 For for IN cord-005453-4057qib7 4594 2 those those DT cord-005453-4057qib7 4594 3 patients patient NNS cord-005453-4057qib7 4594 4 who who WP cord-005453-4057qib7 4594 5 were be VBD cord-005453-4057qib7 4594 6 admitted admit VBN cord-005453-4057qib7 4594 7 to to IN cord-005453-4057qib7 4594 8 ICU ICU NNP cord-005453-4057qib7 4594 9 more more JJR cord-005453-4057qib7 4594 10 than than IN cord-005453-4057qib7 4594 11 once once RB cord-005453-4057qib7 4594 12 , , , cord-005453-4057qib7 4594 13 outcome outcome NN cord-005453-4057qib7 4594 14 was be VBD cord-005453-4057qib7 4594 15 analysed analyse VBN cord-005453-4057qib7 4594 16 from from IN cord-005453-4057qib7 4594 17 their -PRON- PRP$ cord-005453-4057qib7 4594 18 last last JJ cord-005453-4057qib7 4594 19 ICU ICU NNP cord-005453-4057qib7 4594 20 admission admission NN cord-005453-4057qib7 4594 21 . . . cord-005453-4057qib7 4595 1 Results result NNS cord-005453-4057qib7 4595 2 : : : cord-005453-4057qib7 4595 3 20 20 CD cord-005453-4057qib7 4595 4 allograft allograft NN cord-005453-4057qib7 4595 5 patients patient NNS cord-005453-4057qib7 4595 6 were be VBD cord-005453-4057qib7 4595 7 included include VBN cord-005453-4057qib7 4595 8 . . . cord-005453-4057qib7 4596 1 14 14 CD cord-005453-4057qib7 4596 2 were be VBD cord-005453-4057qib7 4596 3 male male JJ cord-005453-4057qib7 4596 4 , , , cord-005453-4057qib7 4596 5 with with IN cord-005453-4057qib7 4596 6 a a DT cord-005453-4057qib7 4596 7 median median JJ cord-005453-4057qib7 4596 8 age age NN cord-005453-4057qib7 4596 9 47 47 CD cord-005453-4057qib7 4596 10 years year NNS cord-005453-4057qib7 4597 1 ( ( -LRB- cord-005453-4057qib7 4597 2 range range NNP cord-005453-4057qib7 4597 3 23 23 CD cord-005453-4057qib7 4597 4 - - SYM cord-005453-4057qib7 4597 5 68 68 CD cord-005453-4057qib7 4597 6 years year NNS cord-005453-4057qib7 4597 7 ) ) -RRB- cord-005453-4057qib7 4597 8 . . . cord-005453-4057qib7 4598 1 6 6 CD cord-005453-4057qib7 4598 2 were be VBD cord-005453-4057qib7 4598 3 female female JJ cord-005453-4057qib7 4598 4 , , , cord-005453-4057qib7 4598 5 with with IN cord-005453-4057qib7 4598 6 median median JJ cord-005453-4057qib7 4598 7 age age NN cord-005453-4057qib7 4598 8 61 61 CD cord-005453-4057qib7 4598 9 years year NNS cord-005453-4057qib7 4599 1 ( ( -LRB- cord-005453-4057qib7 4599 2 range range NNP cord-005453-4057qib7 4599 3 51 51 CD cord-005453-4057qib7 4599 4 - - SYM cord-005453-4057qib7 4599 5 67 67 CD cord-005453-4057qib7 4599 6 years year NNS cord-005453-4057qib7 4599 7 ) ) -RRB- cord-005453-4057qib7 4599 8 . . . cord-005453-4057qib7 4600 1 Diagnosis diagnosis NN cord-005453-4057qib7 4600 2 N n CD cord-005453-4057qib7 4600 3 ( ( -LRB- cord-005453-4057qib7 4600 4 % % NN cord-005453-4057qib7 4600 5 ) ) -RRB- cord-005453-4057qib7 4600 6 includes include VBZ cord-005453-4057qib7 4600 7 ALL all DT cord-005453-4057qib7 4600 8 3 3 CD cord-005453-4057qib7 4600 9 ( ( -LRB- cord-005453-4057qib7 4600 10 15 15 CD cord-005453-4057qib7 4600 11 % % NN cord-005453-4057qib7 4600 12 ) ) -RRB- cord-005453-4057qib7 4600 13 , , , cord-005453-4057qib7 4600 14 AML AML NNP cord-005453-4057qib7 4600 15 7 7 CD cord-005453-4057qib7 4600 16 ( ( -LRB- cord-005453-4057qib7 4600 17 35 35 CD cord-005453-4057qib7 4600 18 % % NN cord-005453-4057qib7 4600 19 ) ) -RRB- cord-005453-4057qib7 4600 20 , , , cord-005453-4057qib7 4600 21 aCML acml JJ cord-005453-4057qib7 4600 22 1 1 CD cord-005453-4057qib7 4600 23 ( ( -LRB- cord-005453-4057qib7 4600 24 5 5 CD cord-005453-4057qib7 4600 25 % % NN cord-005453-4057qib7 4600 26 ) ) -RRB- cord-005453-4057qib7 4600 27 , , , cord-005453-4057qib7 4600 28 CMML CMML NNP cord-005453-4057qib7 4600 29 3 3 CD cord-005453-4057qib7 4600 30 ( ( -LRB- cord-005453-4057qib7 4600 31 15 15 CD cord-005453-4057qib7 4600 32 % % NN cord-005453-4057qib7 4600 33 ) ) -RRB- cord-005453-4057qib7 4600 34 , , , cord-005453-4057qib7 4600 35 HL HL NNP cord-005453-4057qib7 4600 36 1 1 CD cord-005453-4057qib7 4600 37 ( ( -LRB- cord-005453-4057qib7 4600 38 5 5 CD cord-005453-4057qib7 4600 39 % % NN cord-005453-4057qib7 4600 40 ) ) -RRB- cord-005453-4057qib7 4600 41 , , , cord-005453-4057qib7 4600 42 MDS MDS NNP cord-005453-4057qib7 4600 43 2 2 CD cord-005453-4057qib7 4600 44 ( ( -LRB- cord-005453-4057qib7 4600 45 10 10 CD cord-005453-4057qib7 4600 46 % % NN cord-005453-4057qib7 4600 47 ) ) -RRB- cord-005453-4057qib7 4600 48 , , , cord-005453-4057qib7 4600 49 MDS MDS NNP cord-005453-4057qib7 4600 50 / / SYM cord-005453-4057qib7 4600 51 MPN MPN NNP cord-005453-4057qib7 4600 52 1 1 CD cord-005453-4057qib7 4600 53 ( ( -LRB- cord-005453-4057qib7 4600 54 5 5 CD cord-005453-4057qib7 4600 55 % % NN cord-005453-4057qib7 4600 56 ) ) -RRB- cord-005453-4057qib7 4600 57 , , , cord-005453-4057qib7 4600 58 FL FL NNP cord-005453-4057qib7 4600 59 1 1 CD cord-005453-4057qib7 4600 60 ( ( -LRB- cord-005453-4057qib7 4600 61 5 5 CD cord-005453-4057qib7 4600 62 % % NN cord-005453-4057qib7 4600 63 ) ) -RRB- cord-005453-4057qib7 4600 64 , , , cord-005453-4057qib7 4600 65 SCD SCD NNP cord-005453-4057qib7 4600 66 1 1 CD cord-005453-4057qib7 4600 67 ( ( -LRB- cord-005453-4057qib7 4600 68 5 5 CD cord-005453-4057qib7 4600 69 % % NN cord-005453-4057qib7 4600 70 ) ) -RRB- cord-005453-4057qib7 4600 71 . . . cord-005453-4057qib7 4601 1 Sixteen sixteen CD cord-005453-4057qib7 4601 2 ( ( -LRB- cord-005453-4057qib7 4601 3 80 80 CD cord-005453-4057qib7 4601 4 % % NN cord-005453-4057qib7 4601 5 ) ) -RRB- cord-005453-4057qib7 4602 1 patients patient NNS cord-005453-4057qib7 4602 2 received receive VBD cord-005453-4057qib7 4602 3 their -PRON- PRP$ cord-005453-4057qib7 4602 4 first first JJ cord-005453-4057qib7 4602 5 transplant transplant NN cord-005453-4057qib7 4602 6 , , , cord-005453-4057qib7 4602 7 4 4 CD cord-005453-4057qib7 4602 8 ( ( -LRB- cord-005453-4057qib7 4602 9 20 20 CD cord-005453-4057qib7 4602 10 % % NN cord-005453-4057qib7 4602 11 ) ) -RRB- cord-005453-4057qib7 4602 12 received receive VBD cord-005453-4057qib7 4602 13 second second JJ cord-005453-4057qib7 4602 14 transplant transplant NN cord-005453-4057qib7 4602 15 . . . cord-005453-4057qib7 4603 1 Eight eight CD cord-005453-4057qib7 4603 2 ( ( -LRB- cord-005453-4057qib7 4603 3 40 40 CD cord-005453-4057qib7 4603 4 % % NN cord-005453-4057qib7 4603 5 ) ) -RRB- cord-005453-4057qib7 4604 1 patients patient NNS cord-005453-4057qib7 4604 2 had have VBD cord-005453-4057qib7 4604 3 sibling sibling NN cord-005453-4057qib7 4604 4 donor donor NN cord-005453-4057qib7 4604 5 , , , cord-005453-4057qib7 4604 6 12 12 CD cord-005453-4057qib7 4604 7 patients patient NNS cord-005453-4057qib7 4604 8 ( ( -LRB- cord-005453-4057qib7 4604 9 60 60 CD cord-005453-4057qib7 4604 10 % % NN cord-005453-4057qib7 4604 11 ) ) -RRB- cord-005453-4057qib7 4604 12 had have VBD cord-005453-4057qib7 4604 13 unrelated unrelated JJ cord-005453-4057qib7 4604 14 donor donor NN cord-005453-4057qib7 4604 15 . . . cord-005453-4057qib7 4605 1 Sixteen sixteen CD cord-005453-4057qib7 4605 2 ( ( -LRB- cord-005453-4057qib7 4605 3 80 80 CD cord-005453-4057qib7 4605 4 % % NN cord-005453-4057qib7 4605 5 ) ) -RRB- cord-005453-4057qib7 4606 1 patients patient NNS cord-005453-4057qib7 4606 2 had have VBD cord-005453-4057qib7 4606 3 10/10 10/10 CD cord-005453-4057qib7 4606 4 matched match VBN cord-005453-4057qib7 4606 5 donor donor NN cord-005453-4057qib7 4606 6 , , , cord-005453-4057qib7 4606 7 2 2 CD cord-005453-4057qib7 4606 8 ( ( -LRB- cord-005453-4057qib7 4606 9 10 10 CD cord-005453-4057qib7 4606 10 % % NN cord-005453-4057qib7 4606 11 ) ) -RRB- cord-005453-4057qib7 4607 1 patients patient NNS cord-005453-4057qib7 4607 2 had have VBD cord-005453-4057qib7 4607 3 9/ 9/ CD cord-005453-4057qib7 4607 4 10 10 CD cord-005453-4057qib7 4607 5 matched match VBN cord-005453-4057qib7 4607 6 donor donor NN cord-005453-4057qib7 4607 7 , , , cord-005453-4057qib7 4607 8 2 2 CD cord-005453-4057qib7 4607 9 ( ( -LRB- cord-005453-4057qib7 4607 10 10 10 CD cord-005453-4057qib7 4607 11 % % NN cord-005453-4057qib7 4607 12 ) ) -RRB- cord-005453-4057qib7 4608 1 patients patient NNS cord-005453-4057qib7 4608 2 had have VBD cord-005453-4057qib7 4608 3 8/10 8/10 CD cord-005453-4057qib7 4608 4 matched match VBN cord-005453-4057qib7 4608 5 donor donor NN cord-005453-4057qib7 4608 6 . . . cord-005453-4057qib7 4609 1 Nineteen nineteen CD cord-005453-4057qib7 4609 2 ( ( -LRB- cord-005453-4057qib7 4609 3 95 95 CD cord-005453-4057qib7 4609 4 % % NN cord-005453-4057qib7 4609 5 ) ) -RRB- cord-005453-4057qib7 4609 6 received receive VBD cord-005453-4057qib7 4609 7 Reduced reduce VBN cord-005453-4057qib7 4609 8 Intensity intensity NN cord-005453-4057qib7 4609 9 Conditioning Conditioning NNP cord-005453-4057qib7 4609 10 ( ( -LRB- cord-005453-4057qib7 4609 11 RIC RIC NNP cord-005453-4057qib7 4609 12 ) ) -RRB- cord-005453-4057qib7 4609 13 , , , cord-005453-4057qib7 4609 14 one one CD cord-005453-4057qib7 4609 15 ( ( -LRB- cord-005453-4057qib7 4609 16 5 5 CD cord-005453-4057qib7 4609 17 % % NN cord-005453-4057qib7 4609 18 ) ) -RRB- cord-005453-4057qib7 4609 19 received receive VBD cord-005453-4057qib7 4609 20 Myeloablative Myeloablative NNP cord-005453-4057qib7 4609 21 ( ( -LRB- cord-005453-4057qib7 4609 22 MA MA NNP cord-005453-4057qib7 4609 23 ) ) -RRB- cord-005453-4057qib7 4609 24 conditioning conditioning NN cord-005453-4057qib7 4609 25 . . . cord-005453-4057qib7 4610 1 Majority majority NN cord-005453-4057qib7 4610 2 of of IN cord-005453-4057qib7 4610 3 RIC RIC NNP cord-005453-4057qib7 4610 4 allo allo NNP cord-005453-4057qib7 4610 5 - - HYPH cord-005453-4057qib7 4610 6 HSCT HSCT NNP cord-005453-4057qib7 4610 7 patients patient NNS cord-005453-4057qib7 4610 8 were be VBD cord-005453-4057qib7 4610 9 conditioned condition VBN cord-005453-4057qib7 4610 10 with with IN cord-005453-4057qib7 4610 11 Fludarabine Fludarabine NNP cord-005453-4057qib7 4610 12 , , , cord-005453-4057qib7 4610 13 Mephalan Mephalan NNP cord-005453-4057qib7 4610 14 , , , cord-005453-4057qib7 4610 15 Campath Campath NNP cord-005453-4057qib7 4610 16 ( ( -LRB- cord-005453-4057qib7 4610 17 FMC FMC NNP cord-005453-4057qib7 4610 18 ) ) -RRB- cord-005453-4057qib7 4610 19 . . . cord-005453-4057qib7 4611 1 A a DT cord-005453-4057qib7 4611 2 small small JJ cord-005453-4057qib7 4611 3 number number NN cord-005453-4057qib7 4611 4 were be VBD cord-005453-4057qib7 4611 5 conditioned condition VBN cord-005453-4057qib7 4611 6 with with IN cord-005453-4057qib7 4611 7 busulfan busulfan NN cord-005453-4057qib7 4611 8 , , , cord-005453-4057qib7 4611 9 fludarabine fludarabine NN cord-005453-4057qib7 4611 10 and and CC cord-005453-4057qib7 4611 11 ATG ATG NNP cord-005453-4057qib7 4611 12 . . . cord-005453-4057qib7 4612 1 The the DT cord-005453-4057qib7 4612 2 MA MA NNP cord-005453-4057qib7 4612 3 allo allo NNP cord-005453-4057qib7 4612 4 - - HYPH cord-005453-4057qib7 4612 5 HSCT HSCT NNP cord-005453-4057qib7 4612 6 patient patient NN cord-005453-4057qib7 4612 7 was be VBD cord-005453-4057qib7 4612 8 conditioned condition VBN cord-005453-4057qib7 4612 9 with with IN cord-005453-4057qib7 4612 10 TBI TBI NNP cord-005453-4057qib7 4612 11 , , , cord-005453-4057qib7 4612 12 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 4612 13 . . . cord-005453-4057qib7 4613 1 GvHD GvHD NNP cord-005453-4057qib7 4613 2 prophylaxis prophylaxis NN cord-005453-4057qib7 4613 3 was be VBD cord-005453-4057qib7 4613 4 ciclosporin ciclosporin NN cord-005453-4057qib7 4613 5 alone alone RB cord-005453-4057qib7 4613 6 starting start VBG cord-005453-4057qib7 4613 7 on on IN cord-005453-4057qib7 4613 8 day day NN cord-005453-4057qib7 4613 9 -1 -1 . cord-005453-4057qib7 4613 10 with with IN cord-005453-4057qib7 4613 11 a a DT cord-005453-4057qib7 4613 12 target target NN cord-005453-4057qib7 4613 13 level level NN cord-005453-4057qib7 4613 14 of of IN cord-005453-4057qib7 4613 15 150 150 CD cord-005453-4057qib7 4613 16 - - SYM cord-005453-4057qib7 4613 17 250 250 CD cord-005453-4057qib7 4613 18 ug ug NNP cord-005453-4057qib7 4613 19 / / SYM cord-005453-4057qib7 4613 20 L l NN cord-005453-4057qib7 4613 21 for for IN cord-005453-4057qib7 4613 22 all all DT cord-005453-4057qib7 4613 23 RIC RIC NNP cord-005453-4057qib7 4613 24 and and CC cord-005453-4057qib7 4613 25 ciclosporin ciclosporin NNP cord-005453-4057qib7 4613 26 and and CC cord-005453-4057qib7 4613 27 methotrexate methotrexate NNP cord-005453-4057qib7 4613 28 for for IN cord-005453-4057qib7 4613 29 the the DT cord-005453-4057qib7 4613 30 MA MA NNP cord-005453-4057qib7 4613 31 patients patient NNS cord-005453-4057qib7 4613 32 . . . cord-005453-4057qib7 4614 1 Two two CD cord-005453-4057qib7 4614 2 ( ( -LRB- cord-005453-4057qib7 4614 3 10 10 CD cord-005453-4057qib7 4614 4 % % NN cord-005453-4057qib7 4614 5 ) ) -RRB- cord-005453-4057qib7 4614 6 allograft allograft NN cord-005453-4057qib7 4614 7 patients patient NNS cord-005453-4057qib7 4614 8 were be VBD cord-005453-4057qib7 4614 9 admitted admit VBN cord-005453-4057qib7 4614 10 to to IN cord-005453-4057qib7 4614 11 ICU ICU NNP cord-005453-4057qib7 4614 12 on on IN cord-005453-4057qib7 4614 13 three three CD cord-005453-4057qib7 4614 14 occasions occasion NNS cord-005453-4057qib7 4614 15 . . . cord-005453-4057qib7 4615 1 Both both DT cord-005453-4057qib7 4615 2 patients patient NNS cord-005453-4057qib7 4615 3 were be VBD cord-005453-4057qib7 4615 4 male male JJ cord-005453-4057qib7 4615 5 , , , cord-005453-4057qib7 4615 6 58 58 CD cord-005453-4057qib7 4615 7 and and CC cord-005453-4057qib7 4615 8 68 68 CD cord-005453-4057qib7 4615 9 years year NNS cord-005453-4057qib7 4615 10 old old JJ cord-005453-4057qib7 4615 11 . . . cord-005453-4057qib7 4616 1 One one CD cord-005453-4057qib7 4616 2 had have VBD cord-005453-4057qib7 4616 3 MMUD MMUD NNP cord-005453-4057qib7 4616 4 allograft allograft NN cord-005453-4057qib7 4616 5 for for IN cord-005453-4057qib7 4616 6 MDS MDS NNP cord-005453-4057qib7 4616 7 / / SYM cord-005453-4057qib7 4616 8 MPN MPN NNP cord-005453-4057qib7 4616 9 . . . cord-005453-4057qib7 4617 1 The the DT cord-005453-4057qib7 4617 2 other other JJ cord-005453-4057qib7 4617 3 had have VBD cord-005453-4057qib7 4617 4 2 2 CD cord-005453-4057qib7 4617 5 nd nd NNP cord-005453-4057qib7 4617 6 MUD mud NN cord-005453-4057qib7 4617 7 allograft allograft NN cord-005453-4057qib7 4617 8 for for IN cord-005453-4057qib7 4617 9 relapsed relapse VBN cord-005453-4057qib7 4617 10 AML AML NNP cord-005453-4057qib7 4617 11 . . . cord-005453-4057qib7 4618 1 The the DT cord-005453-4057qib7 4618 2 reasons reason NNS cord-005453-4057qib7 4618 3 for for IN cord-005453-4057qib7 4618 4 ICU ICU NNP cord-005453-4057qib7 4618 5 admission admission NN cord-005453-4057qib7 4618 6 include include VBP cord-005453-4057qib7 4618 7 sepsis sepsis NN cord-005453-4057qib7 4618 8 , , , cord-005453-4057qib7 4618 9 cardiac cardiac JJ cord-005453-4057qib7 4618 10 arrest arrest NN cord-005453-4057qib7 4618 11 and and CC cord-005453-4057qib7 4618 12 respiratory respiratory JJ cord-005453-4057qib7 4618 13 failure failure NN cord-005453-4057qib7 4618 14 . . . cord-005453-4057qib7 4619 1 The the DT cord-005453-4057qib7 4619 2 median median JJ cord-005453-4057qib7 4619 3 duration duration NN cord-005453-4057qib7 4619 4 of of IN cord-005453-4057qib7 4619 5 ICU ICU NNP cord-005453-4057qib7 4619 6 admission admission NN cord-005453-4057qib7 4619 7 was be VBD cord-005453-4057qib7 4619 8 5 5 CD cord-005453-4057qib7 4619 9 days day NNS cord-005453-4057qib7 4619 10 ( ( -LRB- cord-005453-4057qib7 4619 11 range range NNP cord-005453-4057qib7 4619 12 2 2 CD cord-005453-4057qib7 4619 13 - - SYM cord-005453-4057qib7 4619 14 9 9 CD cord-005453-4057qib7 4619 15 ) ) -RRB- cord-005453-4057qib7 4619 16 . . . cord-005453-4057qib7 4620 1 There there EX cord-005453-4057qib7 4620 2 were be VBD cord-005453-4057qib7 4620 3 2 2 CD cord-005453-4057qib7 4620 4 deaths death NNS cord-005453-4057qib7 4620 5 within within IN cord-005453-4057qib7 4620 6 100 100 CD cord-005453-4057qib7 4620 7 days day NNS cord-005453-4057qib7 4620 8 of of IN cord-005453-4057qib7 4620 9 transplant transplant NN cord-005453-4057qib7 4620 10 . . . cord-005453-4057qib7 4621 1 One one CD cord-005453-4057qib7 4621 2 patient patient NN cord-005453-4057qib7 4621 3 died die VBD cord-005453-4057qib7 4621 4 on on IN cord-005453-4057qib7 4621 5 day day NN cord-005453-4057qib7 4621 6 +11 +11 NNS cord-005453-4057qib7 4621 7 during during IN cord-005453-4057qib7 4621 8 his -PRON- PRP$ cord-005453-4057qib7 4621 9 second second JJ cord-005453-4057qib7 4621 10 ICU ICU NNP cord-005453-4057qib7 4621 11 admission admission NN cord-005453-4057qib7 4621 12 with with IN cord-005453-4057qib7 4621 13 multi multi JJ cord-005453-4057qib7 4621 14 organ organ NN cord-005453-4057qib7 4621 15 failure failure NN cord-005453-4057qib7 4621 16 ( ( -LRB- cord-005453-4057qib7 4621 17 MOF MOF NNP cord-005453-4057qib7 4621 18 ) ) -RRB- cord-005453-4057qib7 4621 19 . . . cord-005453-4057qib7 4622 1 One one CD cord-005453-4057qib7 4622 2 patient patient NN cord-005453-4057qib7 4622 3 died die VBD cord-005453-4057qib7 4622 4 after after IN cord-005453-4057qib7 4622 5 ICU ICU NNP cord-005453-4057qib7 4622 6 discharge discharge NN cord-005453-4057qib7 4622 7 on on IN cord-005453-4057qib7 4622 8 day day NN cord-005453-4057qib7 4622 9 +23 +23 CD cord-005453-4057qib7 4622 10 with with IN cord-005453-4057qib7 4622 11 relapsed relapsed JJ cord-005453-4057qib7 4622 12 disease disease NN cord-005453-4057qib7 4622 13 , , , cord-005453-4057qib7 4622 14 bronchopneumonia bronchopneumonia NN cord-005453-4057qib7 4622 15 with with IN cord-005453-4057qib7 4622 16 disseminated disseminate VBN cord-005453-4057qib7 4622 17 fungal fungal JJ cord-005453-4057qib7 4622 18 infection infection NN cord-005453-4057qib7 4622 19 . . . cord-005453-4057qib7 4623 1 ICU ICU NNP cord-005453-4057qib7 4623 2 mortality mortality NN cord-005453-4057qib7 4623 3 rate rate NN cord-005453-4057qib7 4623 4 was be VBD cord-005453-4057qib7 4623 5 50 50 CD cord-005453-4057qib7 4623 6 % % NN cord-005453-4057qib7 4623 7 , , , cord-005453-4057qib7 4623 8 and and CC cord-005453-4057qib7 4623 9 100-day 100-day JJ cord-005453-4057qib7 4623 10 mortality mortality NN cord-005453-4057qib7 4623 11 rate rate NN cord-005453-4057qib7 4623 12 was be VBD cord-005453-4057qib7 4623 13 10 10 CD cord-005453-4057qib7 4623 14 % % NN cord-005453-4057qib7 4623 15 . . . cord-005453-4057qib7 4624 1 Nineteen nineteen CD cord-005453-4057qib7 4624 2 autologous autologous JJ cord-005453-4057qib7 4624 3 patients patient NNS cord-005453-4057qib7 4624 4 were be VBD cord-005453-4057qib7 4624 5 included include VBN cord-005453-4057qib7 4624 6 ( ( -LRB- cord-005453-4057qib7 4624 7 median median JJ cord-005453-4057qib7 4624 8 age age NN cord-005453-4057qib7 4624 9 61 61 CD cord-005453-4057qib7 4624 10 ( ( -LRB- cord-005453-4057qib7 4624 11 range range NNP cord-005453-4057qib7 4624 12 36 36 CD cord-005453-4057qib7 4624 13 - - SYM cord-005453-4057qib7 4624 14 71 71 CD cord-005453-4057qib7 4624 15 years year NNS cord-005453-4057qib7 4624 16 ) ) -RRB- cord-005453-4057qib7 4624 17 ) ) -RRB- cord-005453-4057qib7 4624 18 , , , cord-005453-4057qib7 4624 19 16 16 CD cord-005453-4057qib7 4624 20 ( ( -LRB- cord-005453-4057qib7 4624 21 84 84 CD cord-005453-4057qib7 4624 22 % % NN cord-005453-4057qib7 4624 23 ) ) -RRB- cord-005453-4057qib7 4624 24 were be VBD cord-005453-4057qib7 4624 25 myeloma myeloma NN cord-005453-4057qib7 4624 26 patients patient NNS cord-005453-4057qib7 4624 27 who who WP cord-005453-4057qib7 4624 28 were be VBD cord-005453-4057qib7 4624 29 conditioned condition VBN cord-005453-4057qib7 4624 30 with with IN cord-005453-4057qib7 4624 31 melphalan melphalan NNP cord-005453-4057qib7 4624 32 , , , cord-005453-4057qib7 4624 33 3 3 CD cord-005453-4057qib7 4624 34 ( ( -LRB- cord-005453-4057qib7 4624 35 16 16 CD cord-005453-4057qib7 4624 36 % % NN cord-005453-4057qib7 4624 37 ) ) -RRB- cord-005453-4057qib7 4624 38 were be VBD cord-005453-4057qib7 4624 39 lymphoma lymphoma NN cord-005453-4057qib7 4624 40 patients patient NNS cord-005453-4057qib7 4624 41 who who WP cord-005453-4057qib7 4624 42 were be VBD cord-005453-4057qib7 4624 43 conditioned condition VBN cord-005453-4057qib7 4624 44 with with IN cord-005453-4057qib7 4624 45 BEAM BEAM NNP cord-005453-4057qib7 4624 46 . . . cord-005453-4057qib7 4625 1 The the DT cord-005453-4057qib7 4625 2 ICU ICU NNP cord-005453-4057qib7 4625 3 admission admission NN cord-005453-4057qib7 4625 4 was be VBD cord-005453-4057qib7 4625 5 0 0 CD cord-005453-4057qib7 4625 6 % % NN cord-005453-4057qib7 4625 7 . . . cord-005453-4057qib7 4626 1 The the DT cord-005453-4057qib7 4626 2 100-day 100-day JJ cord-005453-4057qib7 4626 3 mortality mortality NN cord-005453-4057qib7 4626 4 rate rate NN cord-005453-4057qib7 4626 5 was be VBD cord-005453-4057qib7 4626 6 0 0 CD cord-005453-4057qib7 4626 7 % % NN cord-005453-4057qib7 4626 8 . . . cord-005453-4057qib7 4627 1 Conclusions conclusion NNS cord-005453-4057qib7 4627 2 : : : cord-005453-4057qib7 4628 1 Our -PRON- PRP$ cord-005453-4057qib7 4628 2 centre centre NN cord-005453-4057qib7 4628 3 's 's POS cord-005453-4057qib7 4628 4 ICU ICU NNP cord-005453-4057qib7 4628 5 admission admission NN cord-005453-4057qib7 4628 6 rate rate NN cord-005453-4057qib7 4628 7 , , , cord-005453-4057qib7 4628 8 ICU ICU NNP cord-005453-4057qib7 4628 9 mortality mortality NN cord-005453-4057qib7 4628 10 rate rate NN cord-005453-4057qib7 4628 11 , , , cord-005453-4057qib7 4628 12 cause cause NN cord-005453-4057qib7 4628 13 of of IN cord-005453-4057qib7 4628 14 ICU ICU NNP cord-005453-4057qib7 4628 15 admission admission NN cord-005453-4057qib7 4628 16 in in IN cord-005453-4057qib7 4628 17 allo allo NNP cord-005453-4057qib7 4628 18 - - HYPH cord-005453-4057qib7 4628 19 HSCT HSCT NNP cord-005453-4057qib7 4628 20 patients patient NNS cord-005453-4057qib7 4628 21 and and CC cord-005453-4057qib7 4628 22 autologous autologous JJ cord-005453-4057qib7 4628 23 patients patient NNS cord-005453-4057qib7 4628 24 is be VBZ cord-005453-4057qib7 4628 25 comparable comparable JJ cord-005453-4057qib7 4628 26 to to IN cord-005453-4057qib7 4628 27 literature literature NN cord-005453-4057qib7 4628 28 reports report NNS cord-005453-4057qib7 4628 29 . . . cord-005453-4057qib7 4629 1 Autologous autologous JJ cord-005453-4057qib7 4629 2 transplant transplant NN cord-005453-4057qib7 4629 3 is be VBZ cord-005453-4057qib7 4629 4 safe safe JJ cord-005453-4057qib7 4629 5 with with IN cord-005453-4057qib7 4629 6 no no DT cord-005453-4057qib7 4629 7 deaths death NNS cord-005453-4057qib7 4629 8 and and CC cord-005453-4057qib7 4629 9 ICU ICU NNP cord-005453-4057qib7 4629 10 admissions admission NNS cord-005453-4057qib7 4629 11 despite despite IN cord-005453-4057qib7 4629 12 an an DT cord-005453-4057qib7 4629 13 older old JJR cord-005453-4057qib7 4629 14 age age NN cord-005453-4057qib7 4629 15 . . . cord-005453-4057qib7 4630 1 The the DT cord-005453-4057qib7 4630 2 mortality mortality NN cord-005453-4057qib7 4630 3 rate rate NN cord-005453-4057qib7 4630 4 for for IN cord-005453-4057qib7 4630 5 allo allo NN cord-005453-4057qib7 4630 6 - - HYPH cord-005453-4057qib7 4630 7 HSCT HSCT NNP cord-005453-4057qib7 4630 8 patients patient NNS cord-005453-4057qib7 4630 9 requiring require VBG cord-005453-4057qib7 4630 10 ICU ICU NNP cord-005453-4057qib7 4630 11 admission admission NN cord-005453-4057qib7 4630 12 remain remain VBP cord-005453-4057qib7 4630 13 high high JJ cord-005453-4057qib7 4630 14 . . . cord-005453-4057qib7 4631 1 All all DT cord-005453-4057qib7 4631 2 patients patient NNS cord-005453-4057qib7 4631 3 were be VBD cord-005453-4057qib7 4631 4 appropriately appropriately RB cord-005453-4057qib7 4631 5 referred refer VBN cord-005453-4057qib7 4631 6 to to IN cord-005453-4057qib7 4631 7 ICU ICU NNP cord-005453-4057qib7 4631 8 and and CC cord-005453-4057qib7 4631 9 there there EX cord-005453-4057qib7 4631 10 was be VBD cord-005453-4057qib7 4631 11 no no DT cord-005453-4057qib7 4631 12 one one NN cord-005453-4057qib7 4631 13 who who WP cord-005453-4057qib7 4631 14 was be VBD cord-005453-4057qib7 4631 15 denied deny VBN cord-005453-4057qib7 4631 16 ICU ICU NNP cord-005453-4057qib7 4631 17 admission admission NN cord-005453-4057qib7 4631 18 . . . cord-005453-4057qib7 4632 1 This this DT cord-005453-4057qib7 4632 2 analysis analysis NN cord-005453-4057qib7 4632 3 is be VBZ cord-005453-4057qib7 4632 4 being be VBG cord-005453-4057qib7 4632 5 extended extend VBN cord-005453-4057qib7 4632 6 to to IN cord-005453-4057qib7 4632 7 preceding precede VBG cord-005453-4057qib7 4632 8 years year NNS cord-005453-4057qib7 4632 9 . . . cord-005453-4057qib7 4633 1 Disclosure disclosure NN cord-005453-4057qib7 4633 2 : : : cord-005453-4057qib7 4633 3 Nothing nothing NN cord-005453-4057qib7 4633 4 to to TO cord-005453-4057qib7 4633 5 declare declare VB cord-005453-4057qib7 4633 6 Liposomal Liposomal NNP cord-005453-4057qib7 4633 7 doxorubicin doxorubicin NN cord-005453-4057qib7 4633 8 for for IN cord-005453-4057qib7 4633 9 the the DT cord-005453-4057qib7 4633 10 treatment treatment NN cord-005453-4057qib7 4633 11 of of IN cord-005453-4057qib7 4633 12 iatrogenic iatrogenic JJ cord-005453-4057qib7 4633 13 kaposi kaposi NNP cord-005453-4057qib7 4633 14 sarcoma sarcoma NN cord-005453-4057qib7 4633 15 following follow VBG cord-005453-4057qib7 4633 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 4633 17 stem stem NN cord-005453-4057qib7 4633 18 cell cell NN cord-005453-4057qib7 4633 19 transplantation transplantation NN cord-005453-4057qib7 4633 20 Background background NN cord-005453-4057qib7 4633 21 : : : cord-005453-4057qib7 4634 1 Iatrogenic iatrogenic JJ cord-005453-4057qib7 4634 2 Kaposi Kaposi NNP cord-005453-4057qib7 4634 3 's 's POS cord-005453-4057qib7 4634 4 Sarcoma Sarcoma NNP cord-005453-4057qib7 4634 5 ( ( -LRB- cord-005453-4057qib7 4634 6 iKS iKS NNP cord-005453-4057qib7 4634 7 ) ) -RRB- cord-005453-4057qib7 4634 8 represent represent VB cord-005453-4057qib7 4634 9 a a DT cord-005453-4057qib7 4634 10 rare rare JJ cord-005453-4057qib7 4634 11 complication complication NN cord-005453-4057qib7 4634 12 after after IN cord-005453-4057qib7 4634 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 4634 14 stem stem NN cord-005453-4057qib7 4634 15 cell cell NN cord-005453-4057qib7 4634 16 transplantation transplantation NN cord-005453-4057qib7 4634 17 ( ( -LRB- cord-005453-4057qib7 4634 18 HSCT HSCT NNP cord-005453-4057qib7 4634 19 ) ) -RRB- cord-005453-4057qib7 4634 20 , , , cord-005453-4057qib7 4634 21 related relate VBN cord-005453-4057qib7 4634 22 to to IN cord-005453-4057qib7 4634 23 HHV-8 HHV-8 NNP cord-005453-4057qib7 4634 24 infection infection NN cord-005453-4057qib7 4634 25 in in IN cord-005453-4057qib7 4634 26 HIVnegative hivnegative JJ cord-005453-4057qib7 4634 27 immunocompromised immunocompromised JJ cord-005453-4057qib7 4634 28 patients patient NNS cord-005453-4057qib7 4634 29 ( ( -LRB- cord-005453-4057qib7 4634 30 pts pt NNS cord-005453-4057qib7 4634 31 ) ) -RRB- cord-005453-4057qib7 4634 32 . . . cord-005453-4057qib7 4635 1 Methods method NNS cord-005453-4057qib7 4635 2 : : : cord-005453-4057qib7 4636 1 We -PRON- PRP cord-005453-4057qib7 4636 2 describe describe VBP cord-005453-4057qib7 4636 3 a a DT cord-005453-4057qib7 4636 4 case case NN cord-005453-4057qib7 4636 5 of of IN cord-005453-4057qib7 4636 6 iKS iKS NNP cord-005453-4057qib7 4636 7 occurred occur VBD cord-005453-4057qib7 4636 8 after after IN cord-005453-4057qib7 4636 9 an an DT cord-005453-4057qib7 4636 10 allogeneic allogeneic NN cord-005453-4057qib7 4636 11 HSCT HSCT NNP cord-005453-4057qib7 4637 1 and and CC cord-005453-4057qib7 4637 2 we -PRON- PRP cord-005453-4057qib7 4637 3 provide provide VBP cord-005453-4057qib7 4637 4 a a DT cord-005453-4057qib7 4637 5 review review NN cord-005453-4057qib7 4637 6 of of IN cord-005453-4057qib7 4637 7 the the DT cord-005453-4057qib7 4637 8 literature literature NN cord-005453-4057qib7 4637 9 using use VBG cord-005453-4057qib7 4637 10 Pub Pub NNP cord-005453-4057qib7 4637 11 Med Med NNP cord-005453-4057qib7 4637 12 . . . cord-005453-4057qib7 4638 1 Results result NNS cord-005453-4057qib7 4638 2 : : : cord-005453-4057qib7 4639 1 A a DT cord-005453-4057qib7 4639 2 70-year 70-year JJ cord-005453-4057qib7 4639 3 - - HYPH cord-005453-4057qib7 4639 4 old old JJ cord-005453-4057qib7 4639 5 man man NN cord-005453-4057qib7 4639 6 , , , cord-005453-4057qib7 4639 7 HIV HIV NNP cord-005453-4057qib7 4639 8 - - HYPH cord-005453-4057qib7 4639 9 negative negative JJ cord-005453-4057qib7 4639 10 , , , cord-005453-4057qib7 4639 11 received receive VBD cord-005453-4057qib7 4639 12 full full JJ cord-005453-4057qib7 4639 13 HLA HLA NNP cord-005453-4057qib7 4639 14 - - HYPH cord-005453-4057qib7 4639 15 matched match VBN cord-005453-4057qib7 4639 16 related relate VBN cord-005453-4057qib7 4639 17 HSCT HSCT NNP cord-005453-4057qib7 4639 18 after after IN cord-005453-4057qib7 4639 19 a a DT cord-005453-4057qib7 4639 20 reduced reduce VBN cord-005453-4057qib7 4639 21 intensity intensity NN cord-005453-4057qib7 4639 22 conditioning conditioning NN cord-005453-4057qib7 4639 23 regimen regimen NN cord-005453-4057qib7 4639 24 for for IN cord-005453-4057qib7 4639 25 relapsed relapse VBN cord-005453-4057qib7 4639 26 AML AML NNP cord-005453-4057qib7 4639 27 . . . cord-005453-4057qib7 4640 1 GvHD GvHD NNP cord-005453-4057qib7 4640 2 prophylaxis prophylaxis NN cord-005453-4057qib7 4640 3 was be VBD cord-005453-4057qib7 4640 4 based base VBN cord-005453-4057qib7 4640 5 on on IN cord-005453-4057qib7 4640 6 ATG ATG NNP cord-005453-4057qib7 4640 7 ( ( -LRB- cord-005453-4057qib7 4640 8 Fresenius Fresenius NNP cord-005453-4057qib7 4640 9 30 30 CD cord-005453-4057qib7 4640 10 mg mg NNP cord-005453-4057qib7 4640 11 / / SYM cord-005453-4057qib7 4640 12 Kg Kg NNP cord-005453-4057qib7 4640 13 ) ) -RRB- cord-005453-4057qib7 4640 14 , , , cord-005453-4057qib7 4640 15 cyclosporine cyclosporine NN cord-005453-4057qib7 4640 16 ( ( -LRB- cord-005453-4057qib7 4640 17 Cya Cya NNP cord-005453-4057qib7 4640 18 ) ) -RRB- cord-005453-4057qib7 4640 19 and and CC cord-005453-4057qib7 4640 20 methotrexate methotrexate NNP cord-005453-4057qib7 4640 21 . . . cord-005453-4057qib7 4641 1 No no DT cord-005453-4057qib7 4641 2 severe severe JJ cord-005453-4057qib7 4641 3 complication complication NN cord-005453-4057qib7 4641 4 occurred occur VBD cord-005453-4057qib7 4641 5 in in IN cord-005453-4057qib7 4641 6 the the DT cord-005453-4057qib7 4641 7 first first JJ cord-005453-4057qib7 4641 8 100 100 CD cord-005453-4057qib7 4641 9 days day NNS cord-005453-4057qib7 4641 10 after after IN cord-005453-4057qib7 4641 11 transplant transplant NN cord-005453-4057qib7 4641 12 . . . cord-005453-4057qib7 4642 1 Shortly shortly RB cord-005453-4057qib7 4642 2 after after IN cord-005453-4057qib7 4642 3 Cya Cya NNP cord-005453-4057qib7 4642 4 withdrawal withdrawal NN cord-005453-4057qib7 4642 5 , , , cord-005453-4057qib7 4642 6 he -PRON- PRP cord-005453-4057qib7 4642 7 developed develop VBD cord-005453-4057qib7 4642 8 grade grade NN cord-005453-4057qib7 4642 9 I -PRON- PRP cord-005453-4057qib7 4642 10 acute acute JJ cord-005453-4057qib7 4642 11 GvHD GvHD NNP cord-005453-4057qib7 4642 12 . . . cord-005453-4057qib7 4643 1 GvHD GvHD NNP cord-005453-4057qib7 4643 2 resolved resolve VBN cord-005453-4057qib7 4643 3 after after IN cord-005453-4057qib7 4643 4 restarting restart VBG cord-005453-4057qib7 4643 5 Cya Cya NNP cord-005453-4057qib7 4643 6 . . . cord-005453-4057qib7 4644 1 At at IN cord-005453-4057qib7 4644 2 fifth fifth JJ cord-005453-4057qib7 4644 3 month month NN cord-005453-4057qib7 4644 4 after after IN cord-005453-4057qib7 4644 5 transplant transplant NN cord-005453-4057qib7 4644 6 , , , cord-005453-4057qib7 4644 7 the the DT cord-005453-4057qib7 4644 8 patient patient NN cord-005453-4057qib7 4644 9 developed develop VBD cord-005453-4057qib7 4644 10 several several JJ cord-005453-4057qib7 4644 11 red red JJ cord-005453-4057qib7 4644 12 and and CC cord-005453-4057qib7 4644 13 purple purple JJ cord-005453-4057qib7 4644 14 angiomatous angiomatous JJ cord-005453-4057qib7 4644 15 plaque plaque NN cord-005453-4057qib7 4644 16 and and CC cord-005453-4057qib7 4644 17 nodules nodule NNS cord-005453-4057qib7 4644 18 involving involve VBG cord-005453-4057qib7 4644 19 the the DT cord-005453-4057qib7 4644 20 skin skin NN cord-005453-4057qib7 4644 21 of of IN cord-005453-4057qib7 4644 22 both both DT cord-005453-4057qib7 4644 23 lower low JJR cord-005453-4057qib7 4644 24 limbs limb NNS cord-005453-4057qib7 4644 25 , , , cord-005453-4057qib7 4644 26 right right JJ cord-005453-4057qib7 4644 27 arm arm NN cord-005453-4057qib7 4644 28 and and CC cord-005453-4057qib7 4644 29 the the DT cord-005453-4057qib7 4644 30 nose nose NN cord-005453-4057qib7 4644 31 ( ( -LRB- cord-005453-4057qib7 4644 32 figure figure NN cord-005453-4057qib7 4644 33 1 1 CD cord-005453-4057qib7 4644 34 ) ) -RRB- cord-005453-4057qib7 4644 35 . . . cord-005453-4057qib7 4645 1 Skin skin NN cord-005453-4057qib7 4645 2 biopsy biopsy NN cord-005453-4057qib7 4645 3 revealed reveal VBD cord-005453-4057qib7 4645 4 multiple multiple JJ cord-005453-4057qib7 4645 5 localizations localization NNS cord-005453-4057qib7 4645 6 of of IN cord-005453-4057qib7 4645 7 iKS iKS NNP cord-005453-4057qib7 4645 8 and and CC cord-005453-4057qib7 4645 9 positive positive JJ cord-005453-4057qib7 4645 10 HHV-8 HHV-8 NNP cord-005453-4057qib7 4645 11 viremia viremia NN cord-005453-4057qib7 4645 12 was be VBD cord-005453-4057qib7 4645 13 detected detect VBN cord-005453-4057qib7 4645 14 in in IN cord-005453-4057qib7 4645 15 the the DT cord-005453-4057qib7 4645 16 peripheral peripheral JJ cord-005453-4057qib7 4645 17 blood blood NN cord-005453-4057qib7 4645 18 . . . cord-005453-4057qib7 4646 1 A a DT cord-005453-4057qib7 4646 2 visceral visceral JJ cord-005453-4057qib7 4646 3 involvement involvement NN cord-005453-4057qib7 4646 4 was be VBD cord-005453-4057qib7 4646 5 excluded exclude VBN cord-005453-4057qib7 4646 6 . . . cord-005453-4057qib7 4647 1 Patient Patient NNP cord-005453-4057qib7 4647 2 was be VBD cord-005453-4057qib7 4647 3 treated treat VBN cord-005453-4057qib7 4647 4 with with IN cord-005453-4057qib7 4647 5 Cya Cya NNP cord-005453-4057qib7 4647 6 tapering taper VBG cord-005453-4057qib7 4647 7 and and CC cord-005453-4057qib7 4648 1 nine nine CD cord-005453-4057qib7 4648 2 courses course NNS cord-005453-4057qib7 4648 3 of of IN cord-005453-4057qib7 4648 4 liposomal liposomal JJ cord-005453-4057qib7 4648 5 doxorubicin doxorubicin NN cord-005453-4057qib7 4648 6 20 20 CD cord-005453-4057qib7 4648 7 mg mg NNP cord-005453-4057qib7 4648 8 / / SYM cord-005453-4057qib7 4648 9 m2 m2 NNP cord-005453-4057qib7 4648 10 every every DT cord-005453-4057qib7 4648 11 15 15 CD cord-005453-4057qib7 4648 12 days day NNS cord-005453-4057qib7 4648 13 , , , cord-005453-4057qib7 4648 14 obtaining obtain VBG cord-005453-4057qib7 4648 15 a a DT cord-005453-4057qib7 4648 16 negativity negativity NN cord-005453-4057qib7 4648 17 of of IN cord-005453-4057qib7 4648 18 HHV-8 HHV-8 NNP cord-005453-4057qib7 4648 19 viremia viremia NN cord-005453-4057qib7 4648 20 and and CC cord-005453-4057qib7 4648 21 partial partial JJ cord-005453-4057qib7 4648 22 response response NN cord-005453-4057qib7 4648 23 of of IN cord-005453-4057qib7 4648 24 the the DT cord-005453-4057qib7 4648 25 skin skin NN cord-005453-4057qib7 4648 26 lesions lesion NNS cord-005453-4057qib7 4648 27 . . . cord-005453-4057qib7 4649 1 At at IN cord-005453-4057qib7 4649 2 last last JJ cord-005453-4057qib7 4649 3 follow follow NN cord-005453-4057qib7 4649 4 up up RP cord-005453-4057qib7 4649 5 , , , cord-005453-4057qib7 4649 6 at at IN cord-005453-4057qib7 4649 7 15 15 CD cord-005453-4057qib7 4649 8 months month NNS cord-005453-4057qib7 4649 9 after after IN cord-005453-4057qib7 4649 10 transplant transplant NN cord-005453-4057qib7 4649 11 , , , cord-005453-4057qib7 4649 12 the the DT cord-005453-4057qib7 4649 13 patient patient NN cord-005453-4057qib7 4649 14 was be VBD cord-005453-4057qib7 4649 15 in in IN cord-005453-4057qib7 4649 16 complete complete JJ cord-005453-4057qib7 4649 17 remission remission NN cord-005453-4057qib7 4649 18 ( ( -LRB- cord-005453-4057qib7 4649 19 CR CR NNP cord-005453-4057qib7 4649 20 ) ) -RRB- cord-005453-4057qib7 4649 21 for for IN cord-005453-4057qib7 4649 22 AML AML NNP cord-005453-4057qib7 4649 23 , , , cord-005453-4057qib7 4649 24 Cya Cya NNP cord-005453-4057qib7 4649 25 - - HYPH cord-005453-4057qib7 4649 26 free free JJ cord-005453-4057qib7 4649 27 without without IN cord-005453-4057qib7 4649 28 signs sign NNS cord-005453-4057qib7 4649 29 of of IN cord-005453-4057qib7 4649 30 GvHD gvhd NN cord-005453-4057qib7 4649 31 recurrence recurrence NN cord-005453-4057qib7 4649 32 and and CC cord-005453-4057qib7 4649 33 with with IN cord-005453-4057qib7 4649 34 his -PRON- PRP$ cord-005453-4057qib7 4649 35 single single JJ cord-005453-4057qib7 4649 36 stable stable JJ cord-005453-4057qib7 4649 37 residual residual JJ cord-005453-4057qib7 4649 38 iKS iks DT cord-005453-4057qib7 4649 39 lesion lesion NN cord-005453-4057qib7 4649 40 on on IN cord-005453-4057qib7 4649 41 his -PRON- PRP$ cord-005453-4057qib7 4649 42 left left JJ cord-005453-4057qib7 4649 43 limb limb NN cord-005453-4057qib7 4649 44 , , , cord-005453-4057qib7 4649 45 currently currently RB cord-005453-4057qib7 4649 46 waiting wait VBG cord-005453-4057qib7 4649 47 for for IN cord-005453-4057qib7 4649 48 local local JJ cord-005453-4057qib7 4649 49 radiotherapy radiotherapy NN cord-005453-4057qib7 4649 50 . . . cord-005453-4057qib7 4650 1 We -PRON- PRP cord-005453-4057qib7 4650 2 found find VBD cord-005453-4057qib7 4650 3 additional additional JJ cord-005453-4057qib7 4650 4 18 18 CD cord-005453-4057qib7 4650 5 iKS iKS NNP cord-005453-4057qib7 4650 6 published publish VBN cord-005453-4057qib7 4650 7 cases case NNS cord-005453-4057qib7 4650 8 after after IN cord-005453-4057qib7 4650 9 HSCT HSCT NNP cord-005453-4057qib7 4650 10 . . . cord-005453-4057qib7 4651 1 Most Most JJS cord-005453-4057qib7 4651 2 of of IN cord-005453-4057qib7 4651 3 post post JJ cord-005453-4057qib7 4651 4 - - JJ cord-005453-4057qib7 4651 5 HSCT hsct JJ cord-005453-4057qib7 4651 6 iKS iKS NNP cord-005453-4057qib7 4651 7 were be VBD cord-005453-4057qib7 4651 8 secondary secondary JJ cord-005453-4057qib7 4651 9 to to IN cord-005453-4057qib7 4651 10 an an DT cord-005453-4057qib7 4651 11 allogeneic allogeneic NN cord-005453-4057qib7 4651 12 - - HYPH cord-005453-4057qib7 4651 13 HSCT HSCT NNP cord-005453-4057qib7 4651 14 ( ( -LRB- cord-005453-4057qib7 4651 15 16 16 CD cord-005453-4057qib7 4651 16 out out IN cord-005453-4057qib7 4651 17 of of IN cord-005453-4057qib7 4651 18 19 19 CD cord-005453-4057qib7 4651 19 , , , cord-005453-4057qib7 4651 20 84.2 84.2 CD cord-005453-4057qib7 4651 21 % % NN cord-005453-4057qib7 4651 22 ) ) -RRB- cord-005453-4057qib7 4651 23 and and CC cord-005453-4057qib7 4651 24 occurred occur VBD cord-005453-4057qib7 4651 25 in in IN cord-005453-4057qib7 4651 26 adult adult NN cord-005453-4057qib7 4651 27 ( ( -LRB- cord-005453-4057qib7 4651 28 78,9 78,9 CD cord-005453-4057qib7 4651 29 % % NN cord-005453-4057qib7 4651 30 ) ) -RRB- cord-005453-4057qib7 4651 31 and and CC cord-005453-4057qib7 4651 32 male male NN cord-005453-4057qib7 4651 33 ( ( -LRB- cord-005453-4057qib7 4651 34 68,4 68,4 CD cord-005453-4057qib7 4651 35 % % NN cord-005453-4057qib7 4651 36 ) ) -RRB- cord-005453-4057qib7 4651 37 pts pts NN cord-005453-4057qib7 4651 38 . . . cord-005453-4057qib7 4652 1 Median median JJ cord-005453-4057qib7 4652 2 age age NN cord-005453-4057qib7 4652 3 at at IN cord-005453-4057qib7 4652 4 the the DT cord-005453-4057qib7 4652 5 time time NN cord-005453-4057qib7 4652 6 of of IN cord-005453-4057qib7 4652 7 iKS iks DT cord-005453-4057qib7 4652 8 diagnosis diagnosis NN cord-005453-4057qib7 4652 9 was be VBD cord-005453-4057qib7 4652 10 47.5 47.5 CD cord-005453-4057qib7 4652 11 years year NNS cord-005453-4057qib7 4653 1 ( ( -LRB- cord-005453-4057qib7 4653 2 range range NNP cord-005453-4057qib7 4653 3 7 7 CD cord-005453-4057qib7 4653 4 - - SYM cord-005453-4057qib7 4653 5 70 70 CD cord-005453-4057qib7 4653 6 ) ) -RRB- cord-005453-4057qib7 4653 7 . . . cord-005453-4057qib7 4654 1 Thirteen thirteen CD cord-005453-4057qib7 4654 2 pts pt NNS cord-005453-4057qib7 4654 3 ( ( -LRB- cord-005453-4057qib7 4654 4 68.4 68.4 CD cord-005453-4057qib7 4654 5 % % NN cord-005453-4057qib7 4654 6 ) ) -RRB- cord-005453-4057qib7 4654 7 had have VBD cord-005453-4057qib7 4654 8 Mediterranean mediterranean JJ cord-005453-4057qib7 4654 9 origin origin NN cord-005453-4057qib7 4654 10 . . . cord-005453-4057qib7 4655 1 The the DT cord-005453-4057qib7 4655 2 most most RBS cord-005453-4057qib7 4655 3 frequent frequent JJ cord-005453-4057qib7 4655 4 underlying underlying JJ cord-005453-4057qib7 4655 5 disease disease NN cord-005453-4057qib7 4655 6 was be VBD cord-005453-4057qib7 4655 7 AML AML NNP cord-005453-4057qib7 4655 8 ( ( -LRB- cord-005453-4057qib7 4655 9 47.4 47.4 CD cord-005453-4057qib7 4655 10 % % NN cord-005453-4057qib7 4655 11 ) ) -RRB- cord-005453-4057qib7 4655 12 . . . cord-005453-4057qib7 4656 1 GvHD GvHD NNP cord-005453-4057qib7 4656 2 prophylaxis prophylaxis NN cord-005453-4057qib7 4656 3 was be VBD cord-005453-4057qib7 4656 4 primary primary JJ cord-005453-4057qib7 4656 5 based base VBN cord-005453-4057qib7 4656 6 on on IN cord-005453-4057qib7 4656 7 calcineurin calcineurin JJ cord-005453-4057qib7 4656 8 inhibitor inhibitor NN cord-005453-4057qib7 4656 9 . . . cord-005453-4057qib7 4657 1 Half half NN cord-005453-4057qib7 4657 2 of of IN cord-005453-4057qib7 4657 3 the the DT cord-005453-4057qib7 4657 4 pts pts NN cord-005453-4057qib7 4657 5 developed develop VBD cord-005453-4057qib7 4657 6 GvHD GvHD NNP cord-005453-4057qib7 4657 7 and and CC cord-005453-4057qib7 4657 8 were be VBD cord-005453-4057qib7 4657 9 treated treat VBN cord-005453-4057qib7 4657 10 with with IN cord-005453-4057qib7 4657 11 steroid steroid NN cord-005453-4057qib7 4657 12 and and CC cord-005453-4057qib7 4657 13 other other JJ cord-005453-4057qib7 4657 14 immune immune JJ cord-005453-4057qib7 4657 15 suppressive suppressive JJ cord-005453-4057qib7 4657 16 drugs drug NNS cord-005453-4057qib7 4657 17 . . . cord-005453-4057qib7 4658 1 Median median JJ cord-005453-4057qib7 4658 2 time time NN cord-005453-4057qib7 4658 3 between between IN cord-005453-4057qib7 4658 4 the the DT cord-005453-4057qib7 4658 5 HSCT HSCT NNP cord-005453-4057qib7 4658 6 and and CC cord-005453-4057qib7 4658 7 the the DT cord-005453-4057qib7 4658 8 occurrence occurrence NN cord-005453-4057qib7 4658 9 of of IN cord-005453-4057qib7 4658 10 iKS iKS NNP cord-005453-4057qib7 4658 11 was be VBD cord-005453-4057qib7 4658 12 8.5 8.5 CD cord-005453-4057qib7 4658 13 months month NNS cord-005453-4057qib7 4658 14 ( ( -LRB- cord-005453-4057qib7 4658 15 range range NN cord-005453-4057qib7 4658 16 . . . cord-005453-4057qib7 4659 1 Cutaneous cutaneous JJ cord-005453-4057qib7 4659 2 iKS iKS NNP cord-005453-4057qib7 4659 3 was be VBD cord-005453-4057qib7 4659 4 the the DT cord-005453-4057qib7 4659 5 prevalent prevalent JJ cord-005453-4057qib7 4659 6 form form NN cord-005453-4057qib7 4659 7 of of IN cord-005453-4057qib7 4659 8 manifestation manifestation NN cord-005453-4057qib7 4659 9 , , , cord-005453-4057qib7 4659 10 however however RB cord-005453-4057qib7 4659 11 visceral visceral JJ cord-005453-4057qib7 4659 12 involvement involvement NN cord-005453-4057qib7 4659 13 was be VBD cord-005453-4057qib7 4659 14 reported report VBN cord-005453-4057qib7 4659 15 in in IN cord-005453-4057qib7 4659 16 7 7 CD cord-005453-4057qib7 4659 17 pts pts NN cord-005453-4057qib7 4659 18 ( ( -LRB- cord-005453-4057qib7 4659 19 36.8 36.8 CD cord-005453-4057qib7 4659 20 % % NN cord-005453-4057qib7 4659 21 ) ) -RRB- cord-005453-4057qib7 4659 22 . . . cord-005453-4057qib7 4660 1 In in IN cord-005453-4057qib7 4660 2 four four CD cord-005453-4057qib7 4660 3 cases case NNS cord-005453-4057qib7 4660 4 ( ( -LRB- cord-005453-4057qib7 4660 5 21.1 21.1 CD cord-005453-4057qib7 4660 6 % % NN cord-005453-4057qib7 4660 7 ) ) -RRB- cord-005453-4057qib7 4660 8 an an DT cord-005453-4057qib7 4660 9 HHV-8 HHV-8 NNP cord-005453-4057qib7 4660 10 associated associate VBN cord-005453-4057qib7 4660 11 BM BM NNP cord-005453-4057qib7 4660 12 failure failure NN cord-005453-4057qib7 4660 13 was be VBD cord-005453-4057qib7 4660 14 report report NN cord-005453-4057qib7 4660 15 . . . cord-005453-4057qib7 4661 1 Immune immune JJ cord-005453-4057qib7 4661 2 suppression suppression NN cord-005453-4057qib7 4661 3 drugs drug NNS cord-005453-4057qib7 4661 4 tapering taper VBG cord-005453-4057qib7 4661 5 ( ( -LRB- cord-005453-4057qib7 4661 6 36.8 36.8 CD cord-005453-4057qib7 4661 7 % % NN cord-005453-4057qib7 4661 8 ) ) -RRB- cord-005453-4057qib7 4661 9 and and CC cord-005453-4057qib7 4661 10 chemotherapy chemotherapy NN cord-005453-4057qib7 4661 11 ( ( -LRB- cord-005453-4057qib7 4661 12 26.3 26.3 CD cord-005453-4057qib7 4661 13 % % NN cord-005453-4057qib7 4661 14 ) ) -RRB- cord-005453-4057qib7 4662 1 were be VBD cord-005453-4057qib7 4662 2 the the DT cord-005453-4057qib7 4662 3 most most RBS cord-005453-4057qib7 4662 4 frequent frequent JJ cord-005453-4057qib7 4662 5 actions action NNS cord-005453-4057qib7 4662 6 taken take VBN cord-005453-4057qib7 4662 7 after after IN cord-005453-4057qib7 4662 8 the the DT cord-005453-4057qib7 4662 9 diagnosis diagnosis NN cord-005453-4057qib7 4662 10 of of IN cord-005453-4057qib7 4662 11 iKS iKS NNP cord-005453-4057qib7 4662 12 . . . cord-005453-4057qib7 4663 1 In in IN cord-005453-4057qib7 4663 2 most most JJS cord-005453-4057qib7 4663 3 cases case NNS cord-005453-4057qib7 4663 4 , , , cord-005453-4057qib7 4663 5 liposomal liposomal JJ cord-005453-4057qib7 4663 6 doxorubicin doxorubicin NN cord-005453-4057qib7 4663 7 was be VBD cord-005453-4057qib7 4663 8 used use VBN cord-005453-4057qib7 4663 9 as as IN cord-005453-4057qib7 4663 10 chemotherapy chemotherapy NN cord-005453-4057qib7 4663 11 . . . cord-005453-4057qib7 4664 1 CR cr NN cord-005453-4057qib7 4664 2 rate rate NN cord-005453-4057qib7 4664 3 was be VBD cord-005453-4057qib7 4664 4 high high JJ cord-005453-4057qib7 4664 5 , , , cord-005453-4057qib7 4664 6 63.2 63.2 CD cord-005453-4057qib7 4664 7 % % NN cord-005453-4057qib7 4664 8 , , , cord-005453-4057qib7 4664 9 whereas whereas IN cord-005453-4057qib7 4664 10 progression progression NN cord-005453-4057qib7 4664 11 disease disease NN cord-005453-4057qib7 4664 12 occurred occur VBD cord-005453-4057qib7 4664 13 in in IN cord-005453-4057qib7 4664 14 5 5 CD cord-005453-4057qib7 4664 15 out out RB cord-005453-4057qib7 4664 16 19 19 CD cord-005453-4057qib7 4664 17 pts pt NNS cord-005453-4057qib7 4664 18 ( ( -LRB- cord-005453-4057qib7 4664 19 26.3 26.3 CD cord-005453-4057qib7 4664 20 % % NN cord-005453-4057qib7 4664 21 ) ) -RRB- cord-005453-4057qib7 4664 22 , , , cord-005453-4057qib7 4664 23 all all DT cord-005453-4057qib7 4664 24 of of IN cord-005453-4057qib7 4664 25 which which WDT cord-005453-4057qib7 4664 26 had have VBD cord-005453-4057qib7 4664 27 visceral visceral JJ cord-005453-4057qib7 4664 28 involvement involvement NN cord-005453-4057qib7 4664 29 . . . cord-005453-4057qib7 4665 1 In in IN cord-005453-4057qib7 4665 2 3 3 CD cord-005453-4057qib7 4665 3 pts pts NN cord-005453-4057qib7 4665 4 ( ( -LRB- cord-005453-4057qib7 4665 5 15.8 15.8 CD cord-005453-4057qib7 4665 6 % % NN cord-005453-4057qib7 4665 7 ) ) -RRB- cord-005453-4057qib7 4665 8 , , , cord-005453-4057qib7 4665 9 iKS iKS NNP cord-005453-4057qib7 4665 10 was be VBD cord-005453-4057qib7 4665 11 the the DT cord-005453-4057qib7 4665 12 cause cause NN cord-005453-4057qib7 4665 13 of of IN cord-005453-4057qib7 4665 14 death death NN cord-005453-4057qib7 4665 15 . . . cord-005453-4057qib7 4666 1 Conclusions conclusion NNS cord-005453-4057qib7 4666 2 : : : cord-005453-4057qib7 4667 1 Withdrawn withdraw VBN cord-005453-4057qib7 4667 2 of of IN cord-005453-4057qib7 4667 3 immune immune JJ cord-005453-4057qib7 4667 4 suppression suppression NN cord-005453-4057qib7 4667 5 drugs drug NNS cord-005453-4057qib7 4667 6 and and CC cord-005453-4057qib7 4667 7 anthracycline anthracycline NN cord-005453-4057qib7 4667 8 based base VBN cord-005453-4057qib7 4667 9 chemotherapy chemotherapy NN cord-005453-4057qib7 4667 10 can can MD cord-005453-4057qib7 4667 11 represent represent VB cord-005453-4057qib7 4667 12 a a DT cord-005453-4057qib7 4667 13 feasible feasible JJ cord-005453-4057qib7 4667 14 treatment treatment NN cord-005453-4057qib7 4667 15 option option NN cord-005453-4057qib7 4667 16 for for IN cord-005453-4057qib7 4667 17 pts pt NNS cord-005453-4057qib7 4667 18 with with IN cord-005453-4057qib7 4667 19 iKS iKS NNP cord-005453-4057qib7 4667 20 after after IN cord-005453-4057qib7 4667 21 HSCT HSCT NNP cord-005453-4057qib7 4667 22 . . . cord-005453-4057qib7 4668 1 Clinical clinical JJ cord-005453-4057qib7 4668 2 Background background NN cord-005453-4057qib7 4668 3 : : : cord-005453-4057qib7 4669 1 Acquired acquire VBN cord-005453-4057qib7 4670 1 Haemophilia Haemophilia NNP cord-005453-4057qib7 4670 2 A a DT cord-005453-4057qib7 4670 3 ( ( -LRB- cord-005453-4057qib7 4670 4 AHA aha UH cord-005453-4057qib7 4670 5 ) ) -RRB- cord-005453-4057qib7 4670 6 is be VBZ cord-005453-4057qib7 4670 7 an an DT cord-005453-4057qib7 4670 8 autoimmune autoimmune JJ cord-005453-4057qib7 4670 9 disease disease NN cord-005453-4057qib7 4670 10 caused cause VBN cord-005453-4057qib7 4670 11 by by IN cord-005453-4057qib7 4670 12 the the DT cord-005453-4057qib7 4670 13 spontaneous spontaneous JJ cord-005453-4057qib7 4670 14 production production NN cord-005453-4057qib7 4670 15 of of IN cord-005453-4057qib7 4670 16 neutralizing neutralize VBG cord-005453-4057qib7 4670 17 immunoglobulin immunoglobulin NN cord-005453-4057qib7 4670 18 G G NNP cord-005453-4057qib7 4670 19 ( ( -LRB- cord-005453-4057qib7 4670 20 IgG IgG NNP cord-005453-4057qib7 4670 21 ) ) -RRB- cord-005453-4057qib7 4670 22 autoantibodies autoantibody NNS cord-005453-4057qib7 4670 23 ( ( -LRB- cord-005453-4057qib7 4670 24 inhibitors inhibitor NNS cord-005453-4057qib7 4670 25 ) ) -RRB- cord-005453-4057qib7 4670 26 targeting target VBG cord-005453-4057qib7 4670 27 endogenous endogenous JJ cord-005453-4057qib7 4670 28 FVIII FVIII NNP cord-005453-4057qib7 4670 29 . . . cord-005453-4057qib7 4671 1 Treatment treatment NN cord-005453-4057qib7 4671 2 of of IN cord-005453-4057qib7 4671 3 these these DT cord-005453-4057qib7 4671 4 inhibitors inhibitor NNS cord-005453-4057qib7 4671 5 presents present VBZ cord-005453-4057qib7 4671 6 additional additional JJ cord-005453-4057qib7 4671 7 challenges challenge NNS cord-005453-4057qib7 4671 8 in in IN cord-005453-4057qib7 4671 9 a a DT cord-005453-4057qib7 4671 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 4671 11 stem stem NN cord-005453-4057qib7 4671 12 cell cell NN cord-005453-4057qib7 4671 13 transplantation transplantation NN cord-005453-4057qib7 4671 14 ( ( -LRB- cord-005453-4057qib7 4671 15 HSCT HSCT NNP cord-005453-4057qib7 4671 16 ) ) -RRB- cord-005453-4057qib7 4671 17 recipient recipient NN cord-005453-4057qib7 4671 18 , , , cord-005453-4057qib7 4671 19 because because IN cord-005453-4057qib7 4671 20 preservation preservation NN cord-005453-4057qib7 4671 21 of of IN cord-005453-4057qib7 4671 22 the the DT cord-005453-4057qib7 4671 23 graft graft NN cord-005453-4057qib7 4671 24 that that WDT cord-005453-4057qib7 4671 25 restores restore VBZ cord-005453-4057qib7 4671 26 a a DT cord-005453-4057qib7 4671 27 normal normal JJ cord-005453-4057qib7 4671 28 hematopoiesis hematopoiesis NN cord-005453-4057qib7 4671 29 is be VBZ cord-005453-4057qib7 4671 30 critical critical JJ cord-005453-4057qib7 4671 31 . . . cord-005453-4057qib7 4672 1 Here here RB cord-005453-4057qib7 4672 2 we -PRON- PRP cord-005453-4057qib7 4672 3 describe describe VBP cord-005453-4057qib7 4672 4 the the DT cord-005453-4057qib7 4672 5 management management NN cord-005453-4057qib7 4672 6 of of IN cord-005453-4057qib7 4672 7 a a DT cord-005453-4057qib7 4672 8 case case NN cord-005453-4057qib7 4672 9 of of IN cord-005453-4057qib7 4672 10 AHA AHA NNP cord-005453-4057qib7 4672 11 in in IN cord-005453-4057qib7 4672 12 an an DT cord-005453-4057qib7 4672 13 acute acute JJ cord-005453-4057qib7 4672 14 myeloid myeloid NN cord-005453-4057qib7 4672 15 leukemia leukemia NN cord-005453-4057qib7 4672 16 patient patient NN cord-005453-4057qib7 4672 17 following follow VBG cord-005453-4057qib7 4672 18 HSCT HSCT NNP cord-005453-4057qib7 4672 19 . . . cord-005453-4057qib7 4673 1 Methods method NNS cord-005453-4057qib7 4673 2 : : : cord-005453-4057qib7 4674 1 The the DT cord-005453-4057qib7 4674 2 clinical clinical JJ cord-005453-4057qib7 4674 3 , , , cord-005453-4057qib7 4674 4 laboratory laboratory NN cord-005453-4057qib7 4674 5 and and CC cord-005453-4057qib7 4674 6 molecular molecular JJ cord-005453-4057qib7 4674 7 aspects aspect NNS cord-005453-4057qib7 4674 8 of of IN cord-005453-4057qib7 4674 9 a a DT cord-005453-4057qib7 4674 10 56-year 56-year JJ cord-005453-4057qib7 4674 11 - - HYPH cord-005453-4057qib7 4674 12 old old JJ cord-005453-4057qib7 4674 13 Italian italian JJ cord-005453-4057qib7 4674 14 male male NN cord-005453-4057qib7 4674 15 who who WP cord-005453-4057qib7 4674 16 developed develop VBD cord-005453-4057qib7 4674 17 AHA AHA NNP cord-005453-4057qib7 4674 18 after after IN cord-005453-4057qib7 4674 19 allogenic allogenic JJ cord-005453-4057qib7 4674 20 bone bone NN cord-005453-4057qib7 4674 21 marrow marrow NN cord-005453-4057qib7 4674 22 transplantation transplantation NN cord-005453-4057qib7 4674 23 were be VBD cord-005453-4057qib7 4674 24 collected collect VBN cord-005453-4057qib7 4674 25 and and CC cord-005453-4057qib7 4674 26 presented present VBN cord-005453-4057qib7 4674 27 in in IN cord-005453-4057qib7 4674 28 order order NN cord-005453-4057qib7 4674 29 to to TO cord-005453-4057qib7 4674 30 show show VB cord-005453-4057qib7 4674 31 how how WRB cord-005453-4057qib7 4674 32 we -PRON- PRP cord-005453-4057qib7 4674 33 diagnose diagnose VBP cord-005453-4057qib7 4674 34 and and CC cord-005453-4057qib7 4674 35 manage manage VBP cord-005453-4057qib7 4674 36 this this DT cord-005453-4057qib7 4674 37 severe severe JJ cord-005453-4057qib7 4674 38 but but CC cord-005453-4057qib7 4674 39 rare rare JJ cord-005453-4057qib7 4674 40 complication complication NN cord-005453-4057qib7 4674 41 within within IN cord-005453-4057qib7 4674 42 the the DT cord-005453-4057qib7 4674 43 special special JJ cord-005453-4057qib7 4674 44 setting setting NN cord-005453-4057qib7 4674 45 of of IN cord-005453-4057qib7 4674 46 HSCT HSCT NNP cord-005453-4057qib7 4674 47 . . . cord-005453-4057qib7 4675 1 Results result NNS cord-005453-4057qib7 4675 2 : : : cord-005453-4057qib7 4676 1 A a DT cord-005453-4057qib7 4676 2 56-years 56-years CD cord-005453-4057qib7 4676 3 - - HYPH cord-005453-4057qib7 4676 4 old old JJ cord-005453-4057qib7 4676 5 man man NN cord-005453-4057qib7 4676 6 with with IN cord-005453-4057qib7 4676 7 a a DT cord-005453-4057qib7 4676 8 FLT-3 FLT-3 NNP cord-005453-4057qib7 4677 1 ITD ITD NNP cord-005453-4057qib7 4677 2 , , , cord-005453-4057qib7 4677 3 NPM-1 NPM-1 NNP cord-005453-4057qib7 4677 4 , , , cord-005453-4057qib7 4677 5 RUNX1-RUNX1T1 runx1-runx1t1 NN cord-005453-4057qib7 4677 6 and and CC cord-005453-4057qib7 4677 7 CBFB CBFB NNP cord-005453-4057qib7 4677 8 - - HYPH cord-005453-4057qib7 4677 9 MYH11 MYH11 NNP cord-005453-4057qib7 4678 1 negative negative JJ cord-005453-4057qib7 4678 2 , , , cord-005453-4057qib7 4678 3 not not RB cord-005453-4057qib7 4678 4 differentiated differentiate VBN cord-005453-4057qib7 4679 1 , , , cord-005453-4057qib7 4679 2 chromosomally chromosomally RB cord-005453-4057qib7 4679 3 normal normal JJ cord-005453-4057qib7 4679 4 acute acute JJ cord-005453-4057qib7 4679 5 myeloid myeloid NN cord-005453-4057qib7 4679 6 leukemia leukemia NN cord-005453-4057qib7 4679 7 ( ( -LRB- cord-005453-4057qib7 4679 8 AML AML NNP cord-005453-4057qib7 4679 9 ) ) -RRB- cord-005453-4057qib7 4679 10 in in IN cord-005453-4057qib7 4679 11 third third JJ cord-005453-4057qib7 4679 12 complete complete JJ cord-005453-4057qib7 4679 13 remission remission NN cord-005453-4057qib7 4679 14 ( ( -LRB- cord-005453-4057qib7 4679 15 CR CR NNP cord-005453-4057qib7 4679 16 ) ) -RRB- cord-005453-4057qib7 4679 17 was be VBD cord-005453-4057qib7 4679 18 submitted submit VBN cord-005453-4057qib7 4679 19 to to IN cord-005453-4057qib7 4679 20 a a DT cord-005453-4057qib7 4679 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 4679 22 stem stem NN cord-005453-4057qib7 4679 23 cell cell NN cord-005453-4057qib7 4679 24 transplantation transplantation NN cord-005453-4057qib7 4679 25 ( ( -LRB- cord-005453-4057qib7 4679 26 HSCT HSCT NNP cord-005453-4057qib7 4679 27 ) ) -RRB- cord-005453-4057qib7 4679 28 from from IN cord-005453-4057qib7 4679 29 his -PRON- PRP$ cord-005453-4057qib7 4679 30 haploidentical haploidentical JJ cord-005453-4057qib7 4679 31 son son NN cord-005453-4057qib7 4679 32 . . . cord-005453-4057qib7 4680 1 The the DT cord-005453-4057qib7 4680 2 conditioning conditioning NN cord-005453-4057qib7 4680 3 regimen regimen NN cord-005453-4057qib7 4680 4 consisted consist VBD cord-005453-4057qib7 4680 5 of of IN cord-005453-4057qib7 4680 6 Oncothiotepa Oncothiotepa NNP cord-005453-4057qib7 4680 7 , , , cord-005453-4057qib7 4680 8 Busulfan Busulfan NNP cord-005453-4057qib7 4680 9 and and CC cord-005453-4057qib7 4680 10 Fludarabine Fludarabine NNP cord-005453-4057qib7 4680 11 and and CC cord-005453-4057qib7 4680 12 was be VBD cord-005453-4057qib7 4680 13 followed follow VBN cord-005453-4057qib7 4680 14 by by IN cord-005453-4057qib7 4680 15 the the DT cord-005453-4057qib7 4680 16 infusion infusion NN cord-005453-4057qib7 4680 17 of of IN cord-005453-4057qib7 4680 18 a a DT cord-005453-4057qib7 4680 19 T t NN cord-005453-4057qib7 4680 20 - - HYPH cord-005453-4057qib7 4680 21 cell cell NN cord-005453-4057qib7 4680 22 depleted deplete VBN cord-005453-4057qib7 4680 23 bone bone NN cord-005453-4057qib7 4680 24 marrow marrow NN cord-005453-4057qib7 4680 25 graft graft NN cord-005453-4057qib7 4680 26 . . . cord-005453-4057qib7 4681 1 GVHD GVHD NNP cord-005453-4057qib7 4681 2 prophylaxis prophylaxis NN cord-005453-4057qib7 4681 3 consisted consist VBD cord-005453-4057qib7 4681 4 of of IN cord-005453-4057qib7 4681 5 Cyclosporine Cyclosporine NNP cord-005453-4057qib7 4681 6 A A NNP cord-005453-4057qib7 4681 7 ( ( -LRB- cord-005453-4057qib7 4681 8 CsA csa NN cord-005453-4057qib7 4681 9 ) ) -RRB- cord-005453-4057qib7 4681 10 and and CC cord-005453-4057qib7 4681 11 mycophenolate mycophenolate NNP cord-005453-4057qib7 4681 12 mophetyl mophetyl NNP cord-005453-4057qib7 4681 13 ( ( -LRB- cord-005453-4057qib7 4681 14 MMF MMF NNP cord-005453-4057qib7 4681 15 ) ) -RRB- cord-005453-4057qib7 4681 16 . . . cord-005453-4057qib7 4682 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 4682 2 engraftment engraftment NN cord-005453-4057qib7 4682 3 occurred occur VBD cord-005453-4057qib7 4682 4 on on IN cord-005453-4057qib7 4682 5 day day NN cord-005453-4057qib7 4682 6 +24 +24 CD cord-005453-4057qib7 4682 7 . . . cord-005453-4057qib7 4683 1 Recipient Recipient NNP cord-005453-4057qib7 4683 2 's 's POS cord-005453-4057qib7 4683 3 autoimmunity autoimmunity NN cord-005453-4057qib7 4683 4 was be VBD cord-005453-4057qib7 4683 5 negative negative JJ cord-005453-4057qib7 4683 6 . . . cord-005453-4057qib7 4684 1 At at IN cord-005453-4057qib7 4684 2 27 27 CD cord-005453-4057qib7 4684 3 months month NNS cord-005453-4057qib7 4684 4 post post NN cord-005453-4057qib7 4684 5 - - NN cord-005453-4057qib7 4684 6 transplantation transplantation JJ cord-005453-4057qib7 4684 7 the the DT cord-005453-4057qib7 4684 8 patient patient NN cord-005453-4057qib7 4684 9 received receive VBD cord-005453-4057qib7 4684 10 an an DT cord-005453-4057qib7 4684 11 antipneumococcal antipneumococcal JJ cord-005453-4057qib7 4684 12 vaccination vaccination NN cord-005453-4057qib7 4684 13 . . . cord-005453-4057qib7 4685 1 Fifteen fifteen CD cord-005453-4057qib7 4685 2 days day NNS cord-005453-4057qib7 4685 3 post post NN cord-005453-4057qib7 4685 4 - - JJ cord-005453-4057qib7 4685 5 vaccination vaccination VB cord-005453-4057qib7 4685 6 the the DT cord-005453-4057qib7 4685 7 patient patient NN cord-005453-4057qib7 4685 8 was be VBD cord-005453-4057qib7 4685 9 admitted admit VBN cord-005453-4057qib7 4685 10 to to IN cord-005453-4057qib7 4685 11 our -PRON- PRP$ cord-005453-4057qib7 4685 12 in in IN cord-005453-4057qib7 4685 13 - - HYPH cord-005453-4057qib7 4685 14 patient patient NN cord-005453-4057qib7 4685 15 ward ward NN cord-005453-4057qib7 4685 16 due due IN cord-005453-4057qib7 4685 17 to to IN cord-005453-4057qib7 4685 18 general general JJ cord-005453-4057qib7 4685 19 malaise malaise NN cord-005453-4057qib7 4685 20 , , , cord-005453-4057qib7 4685 21 diffuse diffuse VB cord-005453-4057qib7 4685 22 muscle muscle NN cord-005453-4057qib7 4685 23 and and CC cord-005453-4057qib7 4685 24 joint joint JJ cord-005453-4057qib7 4685 25 pains pain NNS cord-005453-4057qib7 4685 26 , , , cord-005453-4057qib7 4685 27 cutaneous cutaneous JJ cord-005453-4057qib7 4685 28 bleedings bleeding NNS cord-005453-4057qib7 4685 29 , , , cord-005453-4057qib7 4685 30 oedemas oedemas NNP cord-005453-4057qib7 4685 31 , , , cord-005453-4057qib7 4685 32 hyperchromic hyperchromic JJ cord-005453-4057qib7 4685 33 urines urine NNS cord-005453-4057qib7 4685 34 and and CC cord-005453-4057qib7 4685 35 constipation constipation NN cord-005453-4057qib7 4685 36 . . . cord-005453-4057qib7 4686 1 Physical physical JJ cord-005453-4057qib7 4686 2 examination examination NN cord-005453-4057qib7 4686 3 revealed reveal VBD cord-005453-4057qib7 4686 4 diffuse diffuse JJ cord-005453-4057qib7 4686 5 ecchymosis ecchymosis NN cord-005453-4057qib7 4686 6 , , , cord-005453-4057qib7 4686 7 swelling swelling NN cord-005453-4057qib7 4686 8 of of IN cord-005453-4057qib7 4686 9 deep deep JJ cord-005453-4057qib7 4686 10 muscles muscle NNS cord-005453-4057qib7 4686 11 with with IN cord-005453-4057qib7 4686 12 a a DT cord-005453-4057qib7 4686 13 progressive progressive JJ cord-005453-4057qib7 4686 14 functional functional JJ cord-005453-4057qib7 4686 15 disability disability NN cord-005453-4057qib7 4686 16 due due IN cord-005453-4057qib7 4686 17 to to IN cord-005453-4057qib7 4686 18 hematomas hematoma NNS cord-005453-4057qib7 4686 19 and and CC cord-005453-4057qib7 4686 20 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 4686 21 suffusions suffusion NNS cord-005453-4057qib7 4686 22 of of IN cord-005453-4057qib7 4686 23 the the DT cord-005453-4057qib7 4686 24 tongue tongue NN cord-005453-4057qib7 4686 25 frenulum frenulum NN cord-005453-4057qib7 4686 26 . . . cord-005453-4057qib7 4687 1 and and CC cord-005453-4057qib7 4687 2 anti anti JJ cord-005453-4057qib7 4687 3 - - JJ cord-005453-4057qib7 4687 4 factor factor NN cord-005453-4057qib7 4687 5 VIII VIII NNP cord-005453-4057qib7 4687 6 inhibitors inhibitor NNS cord-005453-4057qib7 4687 7 6.46 6.46 CD cord-005453-4057qib7 4687 8 BU BU NNP cord-005453-4057qib7 4687 9 / / SYM cord-005453-4057qib7 4687 10 ml ml NN cord-005453-4057qib7 4687 11 ( ( -LRB- cord-005453-4057qib7 4687 12 high high JJ cord-005453-4057qib7 4687 13 titers titer NNS cord-005453-4057qib7 4688 1 > > XX cord-005453-4057qib7 4689 1 5 5 CD cord-005453-4057qib7 4689 2 BU BU NNP cord-005453-4057qib7 4689 3 / / SYM cord-005453-4057qib7 4689 4 ml ml NN cord-005453-4057qib7 4689 5 ) ) -RRB- cord-005453-4057qib7 4689 6 . . . cord-005453-4057qib7 4690 1 Thus thus RB cord-005453-4057qib7 4690 2 , , , cord-005453-4057qib7 4690 3 a a DT cord-005453-4057qib7 4690 4 diagnosis diagnosis NN cord-005453-4057qib7 4690 5 of of IN cord-005453-4057qib7 4690 6 acquired acquire VBN cord-005453-4057qib7 4690 7 autoimmune autoimmune JJ cord-005453-4057qib7 4690 8 Haemophilia Haemophilia NNP cord-005453-4057qib7 4690 9 A A NNP cord-005453-4057qib7 4690 10 was be VBD cord-005453-4057qib7 4690 11 made make VBN cord-005453-4057qib7 4690 12 and and CC cord-005453-4057qib7 4690 13 treatment treatment NN cord-005453-4057qib7 4690 14 with with IN cord-005453-4057qib7 4690 15 FEIBA FEIBA NNP cord-005453-4057qib7 4690 16 combined combine VBN cord-005453-4057qib7 4690 17 with with IN cord-005453-4057qib7 4690 18 prednisone prednisone NNP cord-005453-4057qib7 4690 19 was be VBD cord-005453-4057qib7 4690 20 started start VBN cord-005453-4057qib7 4690 21 . . . cord-005453-4057qib7 4691 1 Patient Patient NNP cord-005453-4057qib7 4691 2 's 's POS cord-005453-4057qib7 4691 3 clinical clinical JJ cord-005453-4057qib7 4691 4 conditions condition NNS cord-005453-4057qib7 4691 5 dramatically dramatically RB cord-005453-4057qib7 4691 6 improved improve VBD cord-005453-4057qib7 4691 7 as as IN cord-005453-4057qib7 4691 8 he -PRON- PRP cord-005453-4057qib7 4691 9 referred refer VBD cord-005453-4057qib7 4691 10 an an DT cord-005453-4057qib7 4691 11 improvement improvement NN cord-005453-4057qib7 4691 12 of of IN cord-005453-4057qib7 4691 13 movements movement NNS cord-005453-4057qib7 4691 14 and and CC cord-005453-4057qib7 4691 15 the the DT cord-005453-4057qib7 4691 16 resolution resolution NN cord-005453-4057qib7 4691 17 of of IN cord-005453-4057qib7 4691 18 joint joint JJ cord-005453-4057qib7 4691 19 and and CC cord-005453-4057qib7 4691 20 muscle muscle NN cord-005453-4057qib7 4691 21 pains pain NNS cord-005453-4057qib7 4691 22 despite despite IN cord-005453-4057qib7 4691 23 the the DT cord-005453-4057qib7 4691 24 persistence persistence NN cord-005453-4057qib7 4691 25 of of IN cord-005453-4057qib7 4691 26 deep deep JJ cord-005453-4057qib7 4691 27 hematomas hematoma NNS cord-005453-4057qib7 4691 28 just just RB cord-005453-4057qib7 4691 29 after after IN cord-005453-4057qib7 4691 30 one one CD cord-005453-4057qib7 4691 31 day day NN cord-005453-4057qib7 4691 32 of of IN cord-005453-4057qib7 4691 33 treatment treatment NN cord-005453-4057qib7 4691 34 that that WDT cord-005453-4057qib7 4691 35 had have VBD cord-005453-4057qib7 4691 36 determined determine VBN cord-005453-4057qib7 4691 37 an an DT cord-005453-4057qib7 4691 38 increase increase NN cord-005453-4057qib7 4691 39 of of IN cord-005453-4057qib7 4691 40 FVIII FVIII NNP cord-005453-4057qib7 4691 41 : : : cord-005453-4057qib7 4692 1 C C NNP cord-005453-4057qib7 4692 2 value value NN cord-005453-4057qib7 4692 3 to to IN cord-005453-4057qib7 4692 4 1.32 1.32 CD cord-005453-4057qib7 4692 5 % % NN cord-005453-4057qib7 4692 6 and and CC cord-005453-4057qib7 4692 7 an an DT cord-005453-4057qib7 4692 8 improvement improvement NN cord-005453-4057qib7 4692 9 of of IN cord-005453-4057qib7 4692 10 aPTT aptt CD cord-005453-4057qib7 4692 11 to to IN cord-005453-4057qib7 4692 12 47.06 47.06 CD cord-005453-4057qib7 4692 13 seconds second NNS cord-005453-4057qib7 4692 14 . . . cord-005453-4057qib7 4693 1 On on IN cord-005453-4057qib7 4693 2 the the DT cord-005453-4057qib7 4693 3 following follow VBG cord-005453-4057qib7 4693 4 medical medical JJ cord-005453-4057qib7 4693 5 checks check NNS cord-005453-4057qib7 4693 6 physical physical JJ cord-005453-4057qib7 4693 7 examination examination NN cord-005453-4057qib7 4693 8 showed show VBD cord-005453-4057qib7 4693 9 the the DT cord-005453-4057qib7 4693 10 progressive progressive JJ cord-005453-4057qib7 4693 11 disappearance disappearance NN cord-005453-4057qib7 4693 12 of of IN cord-005453-4057qib7 4693 13 deep deep JJ cord-005453-4057qib7 4693 14 muscle muscle NN cord-005453-4057qib7 4693 15 hematomas hematoma NNS cord-005453-4057qib7 4693 16 , , , cord-005453-4057qib7 4693 17 and and CC cord-005453-4057qib7 4693 18 normal normal JJ cord-005453-4057qib7 4693 19 values value NNS cord-005453-4057qib7 4693 20 of of IN cord-005453-4057qib7 4693 21 FVIII FVIII NNS cord-005453-4057qib7 4693 22 : : : cord-005453-4057qib7 4694 1 C. C. NNP cord-005453-4057qib7 4694 2 Conclusions Conclusions NNPS cord-005453-4057qib7 4694 3 : : : cord-005453-4057qib7 4695 1 AHA AHA NNP cord-005453-4057qib7 4695 2 is be VBZ cord-005453-4057qib7 4695 3 a a DT cord-005453-4057qib7 4695 4 rare rare JJ cord-005453-4057qib7 4695 5 but but CC cord-005453-4057qib7 4695 6 severe severe JJ cord-005453-4057qib7 4695 7 complication complication NN cord-005453-4057qib7 4695 8 following follow VBG cord-005453-4057qib7 4695 9 HSCT HSCT NNP cord-005453-4057qib7 4696 1 and and CC cord-005453-4057qib7 4696 2 it -PRON- PRP cord-005453-4057qib7 4696 3 could could MD cord-005453-4057qib7 4696 4 appear appear VB cord-005453-4057qib7 4696 5 years year NNS cord-005453-4057qib7 4696 6 afterengraftment afterengraftment JJ cord-005453-4057qib7 4696 7 . . . cord-005453-4057qib7 4697 1 A a DT cord-005453-4057qib7 4697 2 prompt prompt JJ cord-005453-4057qib7 4697 3 diagnosis diagnosis NN cord-005453-4057qib7 4697 4 and and CC cord-005453-4057qib7 4697 5 an an DT cord-005453-4057qib7 4697 6 early early JJ cord-005453-4057qib7 4697 7 treatment treatment NN cord-005453-4057qib7 4697 8 with with IN cord-005453-4057qib7 4697 9 FEIBA FEIBA NNP cord-005453-4057qib7 4697 10 and and CC cord-005453-4057qib7 4697 11 corticosteroid corticosteroid NN cord-005453-4057qib7 4697 12 are be VBP cord-005453-4057qib7 4697 13 necessary necessary JJ cord-005453-4057qib7 4697 14 to to TO cord-005453-4057qib7 4697 15 avoid avoid VB cord-005453-4057qib7 4697 16 life life NN cord-005453-4057qib7 4697 17 - - HYPH cord-005453-4057qib7 4697 18 threatening threaten VBG cord-005453-4057qib7 4697 19 sequelae sequela NNS cord-005453-4057qib7 4697 20 . . . cord-005453-4057qib7 4698 1 The the DT cord-005453-4057qib7 4698 2 inclusion inclusion NN cord-005453-4057qib7 4698 3 of of IN cord-005453-4057qib7 4698 4 the the DT cord-005453-4057qib7 4698 5 coagulation coagulation NN cord-005453-4057qib7 4698 6 panel panel NN cord-005453-4057qib7 4698 7 in in IN cord-005453-4057qib7 4698 8 the the DT cord-005453-4057qib7 4698 9 laboratory laboratory NN cord-005453-4057qib7 4698 10 exams exam NNS cord-005453-4057qib7 4698 11 performed perform VBN cord-005453-4057qib7 4698 12 during during IN cord-005453-4057qib7 4698 13 the the DT cord-005453-4057qib7 4698 14 follow follow NN cord-005453-4057qib7 4698 15 - - HYPH cord-005453-4057qib7 4698 16 up up NN cord-005453-4057qib7 4698 17 is be VBZ cord-005453-4057qib7 4698 18 advisable advisable JJ cord-005453-4057qib7 4698 19 in in IN cord-005453-4057qib7 4698 20 order order NN cord-005453-4057qib7 4698 21 to to TO cord-005453-4057qib7 4698 22 early early RB cord-005453-4057qib7 4698 23 detect detect VB cord-005453-4057qib7 4698 24 this this DT cord-005453-4057qib7 4698 25 life life NN cord-005453-4057qib7 4698 26 - - HYPH cord-005453-4057qib7 4698 27 threatening threaten VBG cord-005453-4057qib7 4698 28 complication complication NN cord-005453-4057qib7 4698 29 . . . cord-005453-4057qib7 4699 1 Disclosure disclosure NN cord-005453-4057qib7 4699 2 : : : cord-005453-4057qib7 4699 3 Nothing nothing NN cord-005453-4057qib7 4699 4 to to TO cord-005453-4057qib7 4699 5 declare declare VB cord-005453-4057qib7 4699 6 Background background NN cord-005453-4057qib7 4699 7 : : : cord-005453-4057qib7 4700 1 Splanchnic splanchnic JJ cord-005453-4057qib7 4700 2 thrombosis thrombosis NN cord-005453-4057qib7 4700 3 is be VBZ cord-005453-4057qib7 4700 4 an an DT cord-005453-4057qib7 4700 5 uncommon uncommon JJ cord-005453-4057qib7 4700 6 complication complication NN cord-005453-4057qib7 4700 7 of of IN cord-005453-4057qib7 4700 8 myelofibrosis myelofibrosis NN cord-005453-4057qib7 4700 9 and and CC cord-005453-4057qib7 4700 10 a a DT cord-005453-4057qib7 4700 11 controindication controindication NN cord-005453-4057qib7 4700 12 to to TO cord-005453-4057qib7 4700 13 proceed proceed VB cord-005453-4057qib7 4700 14 to to IN cord-005453-4057qib7 4700 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 4700 16 stem stem NN cord-005453-4057qib7 4700 17 cell cell NN cord-005453-4057qib7 4700 18 transplantation transplantation NN cord-005453-4057qib7 4700 19 ( ( -LRB- cord-005453-4057qib7 4700 20 HSCT HSCT NNP cord-005453-4057qib7 4700 21 ) ) -RRB- cord-005453-4057qib7 4700 22 due due IN cord-005453-4057qib7 4700 23 to to IN cord-005453-4057qib7 4700 24 the the DT cord-005453-4057qib7 4700 25 risk risk NN cord-005453-4057qib7 4700 26 of of IN cord-005453-4057qib7 4700 27 additional additional JJ cord-005453-4057qib7 4700 28 vascular vascular JJ cord-005453-4057qib7 4700 29 and and CC cord-005453-4057qib7 4700 30 endothelial endothelial JJ cord-005453-4057qib7 4700 31 complications complication NNS cord-005453-4057qib7 4700 32 . . . cord-005453-4057qib7 4701 1 We -PRON- PRP cord-005453-4057qib7 4701 2 present present VBP cord-005453-4057qib7 4701 3 a a DT cord-005453-4057qib7 4701 4 patient patient NN cord-005453-4057qib7 4701 5 with with IN cord-005453-4057qib7 4701 6 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 4701 7 ( ( -LRB- cord-005453-4057qib7 4701 8 MF MF NNP cord-005453-4057qib7 4701 9 ) ) -RRB- cord-005453-4057qib7 4701 10 that that WDT cord-005453-4057qib7 4701 11 proceeded proceed VBD cord-005453-4057qib7 4701 12 to to IN cord-005453-4057qib7 4701 13 HSCT HSCT NNP cord-005453-4057qib7 4701 14 from from IN cord-005453-4057qib7 4701 15 an an DT cord-005453-4057qib7 4701 16 unrelated unrelated JJ cord-005453-4057qib7 4701 17 donor donor NN cord-005453-4057qib7 4701 18 , , , cord-005453-4057qib7 4701 19 despite despite IN cord-005453-4057qib7 4701 20 splanchnic splanchnic JJ cord-005453-4057qib7 4701 21 thrombosis thrombosis NN cord-005453-4057qib7 4701 22 unresolved unresolved JJ cord-005453-4057qib7 4701 23 after after IN cord-005453-4057qib7 4701 24 heparin heparin JJ cord-005453-4057qib7 4701 25 treatment treatment NN cord-005453-4057qib7 4701 26 and and CC cord-005453-4057qib7 4701 27 unable unable JJ cord-005453-4057qib7 4701 28 to to TO cord-005453-4057qib7 4701 29 proceed proceed VB cord-005453-4057qib7 4701 30 to to IN cord-005453-4057qib7 4701 31 surgical surgical JJ cord-005453-4057qib7 4701 32 treatment treatment NN cord-005453-4057qib7 4701 33 due due IN cord-005453-4057qib7 4701 34 to to IN cord-005453-4057qib7 4701 35 severe severe JJ cord-005453-4057qib7 4701 36 thrombocytemia thrombocytemia NN cord-005453-4057qib7 4701 37 . . . cord-005453-4057qib7 4702 1 Methods method NNS cord-005453-4057qib7 4702 2 : : : cord-005453-4057qib7 4703 1 A a DT cord-005453-4057qib7 4703 2 67-year 67-year JJ cord-005453-4057qib7 4703 3 woman woman NN cord-005453-4057qib7 4703 4 with with IN cord-005453-4057qib7 4703 5 MF MF NNP cord-005453-4057qib7 4703 6 secondary secondary JJ cord-005453-4057qib7 4703 7 to to IN cord-005453-4057qib7 4703 8 essential essential JJ cord-005453-4057qib7 4703 9 thrombocythemia thrombocythemia NN cord-005453-4057qib7 4703 10 , , , cord-005453-4057qib7 4703 11 with with IN cord-005453-4057qib7 4703 12 intermediate-2 intermediate-2 NNP cord-005453-4057qib7 4703 13 score score NN cord-005453-4057qib7 4703 14 according accord VBG cord-005453-4057qib7 4703 15 Dynamic Dynamic NNP cord-005453-4057qib7 4703 16 International International NNP cord-005453-4057qib7 4703 17 Prognostic Prognostic NNP cord-005453-4057qib7 4703 18 Staging Staging NNP cord-005453-4057qib7 4703 19 System System NNP cord-005453-4057qib7 4703 20 ( ( -LRB- cord-005453-4057qib7 4703 21 DIPSS DIPSS NNP cord-005453-4057qib7 4703 22 ) ) -RRB- cord-005453-4057qib7 4703 23 and and CC cord-005453-4057qib7 4703 24 with with IN cord-005453-4057qib7 4703 25 extreme extreme JJ cord-005453-4057qib7 4703 26 splenomegaly splenomegaly NN cord-005453-4057qib7 4703 27 ( ( -LRB- cord-005453-4057qib7 4703 28 maximum maximum JJ cord-005453-4057qib7 4703 29 diameter diameter NN cord-005453-4057qib7 4703 30 30 30 CD cord-005453-4057qib7 4703 31 cm cm NN cord-005453-4057qib7 4703 32 ) ) -RRB- cord-005453-4057qib7 4703 33 , , , cord-005453-4057qib7 4703 34 refractory refractory JJ cord-005453-4057qib7 4703 35 to to IN cord-005453-4057qib7 4703 36 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 4703 37 , , , cord-005453-4057qib7 4703 38 showed show VBD cord-005453-4057qib7 4703 39 an an DT cord-005453-4057qib7 4703 40 extensive extensive JJ cord-005453-4057qib7 4703 41 thrombosis thrombosis NN cord-005453-4057qib7 4703 42 of of IN cord-005453-4057qib7 4703 43 the the DT cord-005453-4057qib7 4703 44 portal portal JJ cord-005453-4057qib7 4703 45 and and CC cord-005453-4057qib7 4703 46 splenic splenic JJ cord-005453-4057qib7 4703 47 veins vein NNS cord-005453-4057qib7 4703 48 , , , cord-005453-4057qib7 4703 49 unresolved unresolved JJ cord-005453-4057qib7 4703 50 after after IN cord-005453-4057qib7 4703 51 4-week 4-week CD cord-005453-4057qib7 4703 52 heparin heparin NN cord-005453-4057qib7 4703 53 therapy therapy NN cord-005453-4057qib7 4703 54 , , , cord-005453-4057qib7 4703 55 at at IN cord-005453-4057qib7 4703 56 the the DT cord-005453-4057qib7 4703 57 time time NN cord-005453-4057qib7 4703 58 of of IN cord-005453-4057qib7 4703 59 availability availability NN cord-005453-4057qib7 4703 60 of of IN cord-005453-4057qib7 4703 61 an an DT cord-005453-4057qib7 4703 62 HLA HLA NNP cord-005453-4057qib7 4703 63 ( ( -LRB- cord-005453-4057qib7 4703 64 8/8 8/8 CD cord-005453-4057qib7 4703 65 ) ) -RRB- cord-005453-4057qib7 4703 66 and and CC cord-005453-4057qib7 4703 67 ABO ABO NNP cord-005453-4057qib7 4703 68 matched match VBD cord-005453-4057qib7 4703 69 unrelated unrelated JJ cord-005453-4057qib7 4703 70 donor donor NN cord-005453-4057qib7 4703 71 . . . cord-005453-4057qib7 4704 1 She -PRON- PRP cord-005453-4057qib7 4704 2 received receive VBD cord-005453-4057qib7 4704 3 a a DT cord-005453-4057qib7 4704 4 conditioning conditioning NN cord-005453-4057qib7 4704 5 regimen regimen NN cord-005453-4057qib7 4704 6 including include VBG cord-005453-4057qib7 4704 7 fludarabine fludarabine NN cord-005453-4057qib7 4704 8 and and CC cord-005453-4057qib7 4704 9 thiotepa thiotepa NNP cord-005453-4057qib7 4704 10 and and CC cord-005453-4057qib7 4704 11 a a DT cord-005453-4057qib7 4704 12 GvHD gvhd NN cord-005453-4057qib7 4704 13 prophylaxis prophylaxis NN cord-005453-4057qib7 4704 14 with with IN cord-005453-4057qib7 4704 15 ATG ATG NNP cord-005453-4057qib7 4704 16 thymoglobuline thymoglobuline NN cord-005453-4057qib7 4704 17 , , , cord-005453-4057qib7 4704 18 cyclosporine cyclosporine NN cord-005453-4057qib7 4704 19 and and CC cord-005453-4057qib7 4704 20 methotrexate methotrexate NNP cord-005453-4057qib7 4704 21 , , , cord-005453-4057qib7 4704 22 followed follow VBN cord-005453-4057qib7 4704 23 by by IN cord-005453-4057qib7 4704 24 the the DT cord-005453-4057qib7 4704 25 reinfusion reinfusion NN cord-005453-4057qib7 4704 26 of of IN cord-005453-4057qib7 4704 27 5.8x10 5.8x10 CD cord-005453-4057qib7 4704 28 6 6 CD cord-005453-4057qib7 4704 29 /kg /kg . cord-005453-4057qib7 4704 30 CD34 CD34 NNP cord-005453-4057qib7 4704 31 + + CC cord-005453-4057qib7 4704 32 PBSC PBSC NNP cord-005453-4057qib7 4704 33 . . . cord-005453-4057qib7 4705 1 At at IN cord-005453-4057qib7 4705 2 the the DT cord-005453-4057qib7 4705 3 time time NN cord-005453-4057qib7 4705 4 of of IN cord-005453-4057qib7 4705 5 transplant transplant NN cord-005453-4057qib7 4705 6 we -PRON- PRP cord-005453-4057qib7 4705 7 were be VBD cord-005453-4057qib7 4705 8 aware aware JJ cord-005453-4057qib7 4705 9 of of IN cord-005453-4057qib7 4705 10 an an DT cord-005453-4057qib7 4705 11 high high JJ cord-005453-4057qib7 4705 12 risk risk NN cord-005453-4057qib7 4705 13 of of IN cord-005453-4057qib7 4705 14 developing develop VBG cord-005453-4057qib7 4705 15 SOS SOS NNP cord-005453-4057qib7 4705 16 , , , cord-005453-4057qib7 4705 17 on on IN cord-005453-4057qib7 4705 18 the the DT cord-005453-4057qib7 4705 19 basis basis NN cord-005453-4057qib7 4705 20 of of IN cord-005453-4057qib7 4705 21 the the DT cord-005453-4057qib7 4705 22 older old JJR cord-005453-4057qib7 4705 23 age age NN cord-005453-4057qib7 4705 24 of of IN cord-005453-4057qib7 4705 25 the the DT cord-005453-4057qib7 4705 26 recipient recipient NN cord-005453-4057qib7 4705 27 , , , cord-005453-4057qib7 4705 28 the the DT cord-005453-4057qib7 4705 29 unrelated unrelated JJ cord-005453-4057qib7 4705 30 donor donor NN cord-005453-4057qib7 4705 31 , , , cord-005453-4057qib7 4705 32 the the DT cord-005453-4057qib7 4705 33 advanced advanced JJ cord-005453-4057qib7 4705 34 stage stage NN cord-005453-4057qib7 4705 35 of of IN cord-005453-4057qib7 4705 36 myelofibrosis myelofibrosis NN cord-005453-4057qib7 4705 37 and and CC cord-005453-4057qib7 4705 38 the the DT cord-005453-4057qib7 4705 39 ferritin ferritin NN cord-005453-4057qib7 4705 40 serum serum NN cord-005453-4057qib7 4705 41 level level NN cord-005453-4057qib7 4705 42 of of IN cord-005453-4057qib7 4705 43 2.223 2.223 CD cord-005453-4057qib7 4705 44 ng ng NNP cord-005453-4057qib7 4705 45 / / SYM cord-005453-4057qib7 4705 46 mg mg NNP cord-005453-4057qib7 4705 47 . . . cord-005453-4057qib7 4706 1 Results result NNS cord-005453-4057qib7 4706 2 : : : cord-005453-4057qib7 4707 1 On on IN cord-005453-4057qib7 4707 2 day day NN cord-005453-4057qib7 4707 3 +9 +9 XX cord-005453-4057qib7 4707 4 after after IN cord-005453-4057qib7 4707 5 HSCT HSCT NNP cord-005453-4057qib7 4707 6 SOS SOS NNP cord-005453-4057qib7 4707 7 complicated complicate VBD cord-005453-4057qib7 4707 8 the the DT cord-005453-4057qib7 4707 9 aplasia aplasia NNP cord-005453-4057qib7 4707 10 phase phase NN cord-005453-4057qib7 4707 11 , , , cord-005453-4057qib7 4707 12 characterized characterize VBN cord-005453-4057qib7 4707 13 by by IN cord-005453-4057qib7 4707 14 jaundice jaundice NN cord-005453-4057qib7 4707 15 , , , cord-005453-4057qib7 4707 16 ascites ascites NN cord-005453-4057qib7 4707 17 , , , cord-005453-4057qib7 4707 18 weight weight NN cord-005453-4057qib7 4707 19 gain gain NN cord-005453-4057qib7 4707 20 , , , cord-005453-4057qib7 4707 21 progressive progressive JJ cord-005453-4057qib7 4707 22 increase increase NN cord-005453-4057qib7 4707 23 in in IN cord-005453-4057qib7 4707 24 creatinine creatinine NN cord-005453-4057qib7 4707 25 and and CC cord-005453-4057qib7 4707 26 bilirubin bilirubin JJ cord-005453-4057qib7 4707 27 serum serum NN cord-005453-4057qib7 4707 28 levels level NNS cord-005453-4057qib7 4707 29 . . . cord-005453-4057qib7 4708 1 An an DT cord-005453-4057qib7 4708 2 ultrasound ultrasound NN cord-005453-4057qib7 4708 3 of of IN cord-005453-4057qib7 4708 4 abdomen abdomen NN cord-005453-4057qib7 4708 5 confirmed confirm VBD cord-005453-4057qib7 4708 6 an an DT cord-005453-4057qib7 4708 7 unchanged unchanged JJ cord-005453-4057qib7 4708 8 thrombosis thrombosis NN cord-005453-4057qib7 4708 9 extension extension NN cord-005453-4057qib7 4708 10 and and CC cord-005453-4057qib7 4708 11 the the DT cord-005453-4057qib7 4708 12 development development NN cord-005453-4057qib7 4708 13 of of IN cord-005453-4057qib7 4708 14 ascites ascite NNS cord-005453-4057qib7 4708 15 . . . cord-005453-4057qib7 4709 1 On on IN cord-005453-4057qib7 4709 2 day day NN cord-005453-4057qib7 4709 3 +10 +10 NFP cord-005453-4057qib7 4709 4 the the DT cord-005453-4057qib7 4709 5 patient patient NN cord-005453-4057qib7 4709 6 was be VBD cord-005453-4057qib7 4709 7 categorized categorize VBN cord-005453-4057qib7 4709 8 as as IN cord-005453-4057qib7 4709 9 very very RB cord-005453-4057qib7 4709 10 severe severe JJ cord-005453-4057qib7 4709 11 SOS SOS NNP cord-005453-4057qib7 4709 12 stage stage NN cord-005453-4057qib7 4709 13 , , , cord-005453-4057qib7 4709 14 according accord VBG cord-005453-4057qib7 4709 15 to to IN cord-005453-4057qib7 4709 16 EBMT EBMT NNP cord-005453-4057qib7 4709 17 severity severity NN cord-005453-4057qib7 4709 18 criteria criterion NNS cord-005453-4057qib7 4709 19 , , , cord-005453-4057qib7 4709 20 because because IN cord-005453-4057qib7 4709 21 of of IN cord-005453-4057qib7 4709 22 doubling doubling NN cord-005453-4057qib7 4709 23 of of IN cord-005453-4057qib7 4709 24 bilirubin bilirubin JJ cord-005453-4057qib7 4709 25 serum serum NN cord-005453-4057qib7 4709 26 level level NN cord-005453-4057qib7 4709 27 in in IN cord-005453-4057qib7 4709 28 48 48 CD cord-005453-4057qib7 4709 29 hours hour NNS cord-005453-4057qib7 4709 30 and and CC cord-005453-4057qib7 4709 31 a a DT cord-005453-4057qib7 4709 32 20 20 CD cord-005453-4057qib7 4709 33 % % NN cord-005453-4057qib7 4709 34 increase increase NN cord-005453-4057qib7 4709 35 in in IN cord-005453-4057qib7 4709 36 comparison comparison NN cord-005453-4057qib7 4709 37 with with IN cord-005453-4057qib7 4709 38 her -PRON- PRP$ cord-005453-4057qib7 4709 39 baseline baseline JJ cord-005453-4057qib7 4709 40 weight weight NN cord-005453-4057qib7 4709 41 . . . cord-005453-4057qib7 4710 1 Therefore therefore RB cord-005453-4057qib7 4710 2 , , , cord-005453-4057qib7 4710 3 defibrotide defibrotide NNP cord-005453-4057qib7 4710 4 was be VBD cord-005453-4057qib7 4710 5 promptly promptly RB cord-005453-4057qib7 4710 6 started start VBN cord-005453-4057qib7 4710 7 in in IN cord-005453-4057qib7 4710 8 association association NN cord-005453-4057qib7 4710 9 with with IN cord-005453-4057qib7 4710 10 diuretic diuretic JJ cord-005453-4057qib7 4710 11 therapy therapy NN cord-005453-4057qib7 4710 12 . . . cord-005453-4057qib7 4711 1 The the DT cord-005453-4057qib7 4711 2 treatment treatment NN cord-005453-4057qib7 4711 3 was be VBD cord-005453-4057qib7 4711 4 continued continue VBN cord-005453-4057qib7 4711 5 for for IN cord-005453-4057qib7 4711 6 3 3 CD cord-005453-4057qib7 4711 7 weeks week NNS cord-005453-4057qib7 4711 8 and and CC cord-005453-4057qib7 4711 9 allowed allow VBD cord-005453-4057qib7 4711 10 gradual gradual JJ cord-005453-4057qib7 4711 11 restoration restoration NN cord-005453-4057qib7 4711 12 of of IN cord-005453-4057qib7 4711 13 the the DT cord-005453-4057qib7 4711 14 water water NN cord-005453-4057qib7 4711 15 balance balance NN cord-005453-4057qib7 4711 16 and and CC cord-005453-4057qib7 4711 17 normalization normalization NN cord-005453-4057qib7 4711 18 of of IN cord-005453-4057qib7 4711 19 bilirubin bilirubin JJ cord-005453-4057qib7 4711 20 serum serum NN cord-005453-4057qib7 4711 21 level level NN cord-005453-4057qib7 4711 22 . . . cord-005453-4057qib7 4712 1 At at IN cord-005453-4057qib7 4712 2 the the DT cord-005453-4057qib7 4712 3 last last JJ cord-005453-4057qib7 4712 4 follow follow NN cord-005453-4057qib7 4712 5 - - HYPH cord-005453-4057qib7 4712 6 up up NN cord-005453-4057qib7 4712 7 , , , cord-005453-4057qib7 4712 8 6 6 CD cord-005453-4057qib7 4712 9 months month NNS cord-005453-4057qib7 4712 10 after after IN cord-005453-4057qib7 4712 11 HSCT HSCT NNP cord-005453-4057qib7 4712 12 , , , cord-005453-4057qib7 4712 13 the the DT cord-005453-4057qib7 4712 14 patient patient NN cord-005453-4057qib7 4712 15 shows show VBZ cord-005453-4057qib7 4712 16 the the DT cord-005453-4057qib7 4712 17 persistence persistence NN cord-005453-4057qib7 4712 18 of of IN cord-005453-4057qib7 4712 19 a a DT cord-005453-4057qib7 4712 20 non non JJ cord-005453-4057qib7 4712 21 - - JJ cord-005453-4057qib7 4712 22 transfusion transfusion JJ cord-005453-4057qib7 4712 23 dependent dependent JJ cord-005453-4057qib7 4712 24 anemia anemia NN cord-005453-4057qib7 4712 25 , , , cord-005453-4057qib7 4712 26 platelets platelet VBZ cord-005453-4057qib7 4712 27 80.000x10 80.000x10 CD cord-005453-4057qib7 4712 28 ^ ^ SYM cord-005453-4057qib7 4712 29 3 3 CD cord-005453-4057qib7 4712 30 / / SYM cord-005453-4057qib7 4712 31 uL ul NN cord-005453-4057qib7 4712 32 , , , cord-005453-4057qib7 4712 33 palpable palpable JJ cord-005453-4057qib7 4712 34 spleen spleen NN cord-005453-4057qib7 4712 35 4 4 CD cord-005453-4057qib7 4712 36 cm cm NNS cord-005453-4057qib7 4712 37 below below IN cord-005453-4057qib7 4712 38 the the DT cord-005453-4057qib7 4712 39 rib rib NN cord-005453-4057qib7 4712 40 , , , cord-005453-4057qib7 4712 41 > > XX cord-005453-4057qib7 4712 42 95 95 CD cord-005453-4057qib7 4712 43 % % NN cord-005453-4057qib7 4712 44 allogeneic allogeneic NN cord-005453-4057qib7 4712 45 chimerism chimerism NN cord-005453-4057qib7 4712 46 in in IN cord-005453-4057qib7 4712 47 the the DT cord-005453-4057qib7 4712 48 granulocytic granulocytic JJ cord-005453-4057qib7 4712 49 compartment compartment NN cord-005453-4057qib7 4712 50 and and CC cord-005453-4057qib7 4712 51 90 90 CD cord-005453-4057qib7 4712 52 % % NN cord-005453-4057qib7 4712 53 in in IN cord-005453-4057qib7 4712 54 the the DT cord-005453-4057qib7 4712 55 T T NNP cord-005453-4057qib7 4712 56 lymphocyte lymphocyte NN cord-005453-4057qib7 4712 57 compartment compartment NN cord-005453-4057qib7 4712 58 . . . cord-005453-4057qib7 4713 1 Splanchnic splanchnic JJ cord-005453-4057qib7 4713 2 thrombosis thrombosis NN cord-005453-4057qib7 4713 3 is be VBZ cord-005453-4057qib7 4713 4 partially partially RB cord-005453-4057qib7 4713 5 recanalized recanalize VBN cord-005453-4057qib7 4713 6 and and CC cord-005453-4057qib7 4713 7 replaced replace VBN cord-005453-4057qib7 4713 8 by by IN cord-005453-4057qib7 4713 9 collateral collateral JJ cord-005453-4057qib7 4713 10 circles circle NNS cord-005453-4057qib7 4713 11 with with IN cord-005453-4057qib7 4713 12 cavernous cavernous JJ cord-005453-4057qib7 4713 13 aspects aspect NNS cord-005453-4057qib7 4713 14 . . . cord-005453-4057qib7 4714 1 The the DT cord-005453-4057qib7 4714 2 patient patient NN cord-005453-4057qib7 4714 3 is be VBZ cord-005453-4057qib7 4714 4 on on IN cord-005453-4057qib7 4714 5 treatment treatment NN cord-005453-4057qib7 4714 6 with with IN cord-005453-4057qib7 4714 7 fondaparinux fondaparinux NNP cord-005453-4057qib7 4714 8 and and CC cord-005453-4057qib7 4714 9 has have VBZ cord-005453-4057qib7 4714 10 shown show VBN cord-005453-4057qib7 4714 11 neither neither CC cord-005453-4057qib7 4714 12 significant significant JJ cord-005453-4057qib7 4714 13 infectious infectious JJ cord-005453-4057qib7 4714 14 episodes episode NNS cord-005453-4057qib7 4714 15 or or CC cord-005453-4057qib7 4714 16 acute acute JJ cord-005453-4057qib7 4714 17 or or CC cord-005453-4057qib7 4714 18 chronic chronic JJ cord-005453-4057qib7 4714 19 GvHD gvhd NN cord-005453-4057qib7 4714 20 . . . cord-005453-4057qib7 4715 1 Conclusions conclusion NNS cord-005453-4057qib7 4715 2 : : : cord-005453-4057qib7 4716 1 We -PRON- PRP cord-005453-4057qib7 4716 2 conclude conclude VBP cord-005453-4057qib7 4716 3 that that IN cord-005453-4057qib7 4716 4 defibrotide defibrotide NN cord-005453-4057qib7 4716 5 treatment treatment NN cord-005453-4057qib7 4716 6 allowed allow VBN cord-005453-4057qib7 4716 7 to to TO cord-005453-4057qib7 4716 8 perform perform VB cord-005453-4057qib7 4716 9 a a DT cord-005453-4057qib7 4716 10 successfull successfull JJ cord-005453-4057qib7 4716 11 allogeneic allogeneic NN cord-005453-4057qib7 4716 12 transplant transplant NN cord-005453-4057qib7 4716 13 in in IN cord-005453-4057qib7 4716 14 a a DT cord-005453-4057qib7 4716 15 patient patient NN cord-005453-4057qib7 4716 16 with with IN cord-005453-4057qib7 4716 17 MF MF NNP cord-005453-4057qib7 4716 18 associated associate VBN cord-005453-4057qib7 4716 19 with with IN cord-005453-4057qib7 4716 20 an an DT cord-005453-4057qib7 4716 21 overt overt JJ cord-005453-4057qib7 4716 22 picture picture NN cord-005453-4057qib7 4716 23 of of IN cord-005453-4057qib7 4716 24 splanchnic splanchnic JJ cord-005453-4057qib7 4716 25 thrombosis thrombosis NN cord-005453-4057qib7 4716 26 . . . cord-005453-4057qib7 4717 1 Background background NN cord-005453-4057qib7 4717 2 : : : cord-005453-4057qib7 4718 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 4718 2 stem stem NN cord-005453-4057qib7 4718 3 cell cell NN cord-005453-4057qib7 4718 4 transplantation transplantation NN cord-005453-4057qib7 4718 5 ( ( -LRB- cord-005453-4057qib7 4718 6 HSCT HSCT NNP cord-005453-4057qib7 4718 7 ) ) -RRB- cord-005453-4057qib7 4718 8 is be VBZ cord-005453-4057qib7 4718 9 associated associate VBN cord-005453-4057qib7 4718 10 with with IN cord-005453-4057qib7 4718 11 an an DT cord-005453-4057qib7 4718 12 increased increase VBN cord-005453-4057qib7 4718 13 incidence incidence NN cord-005453-4057qib7 4718 14 of of IN cord-005453-4057qib7 4718 15 secondary secondary JJ cord-005453-4057qib7 4718 16 malignancies malignancy NNS cord-005453-4057qib7 4718 17 including include VBG cord-005453-4057qib7 4718 18 skin skin NN cord-005453-4057qib7 4718 19 cancer cancer NN cord-005453-4057qib7 4718 20 . . . cord-005453-4057qib7 4719 1 Squamous squamous JJ cord-005453-4057qib7 4719 2 cell cell NN cord-005453-4057qib7 4719 3 carcinoma carcinoma NN cord-005453-4057qib7 4719 4 ( ( -LRB- cord-005453-4057qib7 4719 5 SCC SCC NNP cord-005453-4057qib7 4719 6 ) ) -RRB- cord-005453-4057qib7 4719 7 is be VBZ cord-005453-4057qib7 4719 8 the the DT cord-005453-4057qib7 4719 9 most most RBS cord-005453-4057qib7 4719 10 common common JJ cord-005453-4057qib7 4719 11 type type NN cord-005453-4057qib7 4719 12 in in IN cord-005453-4057qib7 4719 13 patients patient NNS cord-005453-4057qib7 4719 14 who who WP cord-005453-4057qib7 4719 15 are be VBP cord-005453-4057qib7 4719 16 receiving receive VBG cord-005453-4057qib7 4719 17 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4719 18 therapy therapy NN cord-005453-4057qib7 4719 19 and and CC cord-005453-4057qib7 4719 20 chronic chronic JJ cord-005453-4057qib7 4719 21 graft graft NN cord-005453-4057qib7 4719 22 - - HYPH cord-005453-4057qib7 4719 23 versus versus IN cord-005453-4057qib7 4719 24 - - HYPH cord-005453-4057qib7 4719 25 host host NN cord-005453-4057qib7 4719 26 disease disease NN cord-005453-4057qib7 4719 27 ( ( -LRB- cord-005453-4057qib7 4719 28 cGVHD cGVHD NNP cord-005453-4057qib7 4719 29 ) ) -RRB- cord-005453-4057qib7 4719 30 appears appear VBZ cord-005453-4057qib7 4719 31 to to TO cord-005453-4057qib7 4719 32 be be VB cord-005453-4057qib7 4719 33 an an DT cord-005453-4057qib7 4719 34 important important JJ cord-005453-4057qib7 4719 35 risk risk NN cord-005453-4057qib7 4719 36 factor factor NN cord-005453-4057qib7 4719 37 for for IN cord-005453-4057qib7 4719 38 its -PRON- PRP$ cord-005453-4057qib7 4719 39 development development NN cord-005453-4057qib7 4719 40 . . . cord-005453-4057qib7 4720 1 Recent recent JJ cord-005453-4057qib7 4720 2 studies study NNS cord-005453-4057qib7 4720 3 describe describe VBP cord-005453-4057qib7 4720 4 voriconazole voriconazole NN cord-005453-4057qib7 4720 5 exposure exposure NN cord-005453-4057qib7 4720 6 as as IN cord-005453-4057qib7 4720 7 an an DT cord-005453-4057qib7 4720 8 independent independent JJ cord-005453-4057qib7 4720 9 factor factor NN cord-005453-4057qib7 4720 10 that that WDT cord-005453-4057qib7 4720 11 may may MD cord-005453-4057qib7 4720 12 contribute contribute VB cord-005453-4057qib7 4720 13 to to IN cord-005453-4057qib7 4720 14 this this DT cord-005453-4057qib7 4720 15 increased increase VBN cord-005453-4057qib7 4720 16 risk risk NN cord-005453-4057qib7 4720 17 as as RB cord-005453-4057qib7 4720 18 well well RB cord-005453-4057qib7 4720 19 . . . cord-005453-4057qib7 4721 1 In in IN cord-005453-4057qib7 4721 2 our -PRON- PRP$ cord-005453-4057qib7 4721 3 best good JJS cord-005453-4057qib7 4721 4 knowledge knowledge NN cord-005453-4057qib7 4721 5 , , , cord-005453-4057qib7 4721 6 no no DT cord-005453-4057qib7 4721 7 cases case NNS cord-005453-4057qib7 4721 8 of of IN cord-005453-4057qib7 4721 9 SCC SCC NNP cord-005453-4057qib7 4721 10 have have VBP cord-005453-4057qib7 4721 11 been be VBN cord-005453-4057qib7 4721 12 reported report VBN cord-005453-4057qib7 4721 13 in in IN cord-005453-4057qib7 4721 14 pediatric pediatric JJ cord-005453-4057qib7 4721 15 allogeneic allogeneic NN cord-005453-4057qib7 4721 16 HSCT HSCT NNP cord-005453-4057qib7 4721 17 to to IN cord-005453-4057qib7 4721 18 date date NN cord-005453-4057qib7 4721 19 . . . cord-005453-4057qib7 4722 1 Methods method NNS cord-005453-4057qib7 4722 2 : : : cord-005453-4057qib7 4722 3 We -PRON- PRP cord-005453-4057qib7 4722 4 present present VBP cord-005453-4057qib7 4722 5 a a DT cord-005453-4057qib7 4722 6 case case NN cord-005453-4057qib7 4722 7 report report NN cord-005453-4057qib7 4722 8 of of IN cord-005453-4057qib7 4722 9 a a DT cord-005453-4057qib7 4722 10 9 9 CD cord-005453-4057qib7 4722 11 year year NN cord-005453-4057qib7 4722 12 - - HYPH cord-005453-4057qib7 4722 13 old old JJ cord-005453-4057qib7 4722 14 boy boy NN cord-005453-4057qib7 4722 15 who who WP cord-005453-4057qib7 4722 16 developed develop VBD cord-005453-4057qib7 4722 17 a a DT cord-005453-4057qib7 4722 18 SCC SCC NNP cord-005453-4057qib7 4722 19 with with IN cord-005453-4057qib7 4722 20 high high JJ cord-005453-4057qib7 4722 21 - - HYPH cord-005453-4057qib7 4722 22 risk risk NN cord-005453-4057qib7 4722 23 features feature VBZ cord-005453-4057qib7 4722 24 six six CD cord-005453-4057qib7 4722 25 years year NNS cord-005453-4057qib7 4722 26 after after IN cord-005453-4057qib7 4722 27 undergoing undergo VBG cord-005453-4057qib7 4722 28 hematopopoietic hematopopoietic JJ cord-005453-4057qib7 4722 29 stem stem NN cord-005453-4057qib7 4722 30 cell cell NN cord-005453-4057qib7 4722 31 transplant transplant NN cord-005453-4057qib7 4722 32 . . . cord-005453-4057qib7 4723 1 Results result NNS cord-005453-4057qib7 4723 2 : : : cord-005453-4057qib7 4724 1 A a DT cord-005453-4057qib7 4724 2 9 9 CD cord-005453-4057qib7 4724 3 year year NN cord-005453-4057qib7 4724 4 - - HYPH cord-005453-4057qib7 4724 5 old old JJ cord-005453-4057qib7 4724 6 boy boy NN cord-005453-4057qib7 4724 7 with with IN cord-005453-4057qib7 4724 8 acute acute JJ cord-005453-4057qib7 4724 9 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 4724 10 leukemia leukemia NN cord-005453-4057qib7 4724 11 ( ( -LRB- cord-005453-4057qib7 4724 12 ALL all DT cord-005453-4057qib7 4724 13 ) ) -RRB- cord-005453-4057qib7 4724 14 underwent undergo VBD cord-005453-4057qib7 4724 15 a a DT cord-005453-4057qib7 4724 16 matched match VBN cord-005453-4057qib7 4724 17 unrelated unrelated JJ cord-005453-4057qib7 4724 18 bone bone NN cord-005453-4057qib7 4724 19 marrow marrow NN cord-005453-4057qib7 4724 20 transplant transplant NN cord-005453-4057qib7 4724 21 7 7 CD cord-005453-4057qib7 4724 22 years year NNS cord-005453-4057qib7 4724 23 ago ago RB cord-005453-4057qib7 4724 24 . . . cord-005453-4057qib7 4725 1 He -PRON- PRP cord-005453-4057qib7 4725 2 developed develop VBD cord-005453-4057qib7 4725 3 grade grade NN cord-005453-4057qib7 4725 4 IV IV NNP cord-005453-4057qib7 4725 5 aGVHD aGVHD NNP cord-005453-4057qib7 4725 6 followed follow VBN cord-005453-4057qib7 4725 7 by by IN cord-005453-4057qib7 4725 8 extensive extensive JJ cord-005453-4057qib7 4725 9 cGVHD cgvhd NN cord-005453-4057qib7 4725 10 with with IN cord-005453-4057qib7 4725 11 generalized generalized JJ cord-005453-4057qib7 4725 12 scleroderma scleroderma NNS cord-005453-4057qib7 4725 13 . . . cord-005453-4057qib7 4726 1 He -PRON- PRP cord-005453-4057qib7 4726 2 required require VBD cord-005453-4057qib7 4726 3 intensive intensive JJ cord-005453-4057qib7 4726 4 and and CC cord-005453-4057qib7 4726 5 continued continued JJ cord-005453-4057qib7 4726 6 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4726 7 therapy therapy NN cord-005453-4057qib7 4726 8 and and CC cord-005453-4057qib7 4726 9 was be VBD cord-005453-4057qib7 4726 10 on on IN cord-005453-4057qib7 4726 11 prolonged prolong VBN cord-005453-4057qib7 4726 12 antifungal antifungal JJ cord-005453-4057qib7 4726 13 prophylaxis prophylaxis NN cord-005453-4057qib7 4726 14 with with IN cord-005453-4057qib7 4726 15 voriconazole voriconazole NNP cord-005453-4057qib7 4726 16 . . . cord-005453-4057qib7 4727 1 In in IN cord-005453-4057qib7 4727 2 March March NNP cord-005453-4057qib7 4727 3 2017 2017 CD cord-005453-4057qib7 4727 4 , , , cord-005453-4057qib7 4727 5 he -PRON- PRP cord-005453-4057qib7 4727 6 developed develop VBD cord-005453-4057qib7 4727 7 SCC SCC NNP cord-005453-4057qib7 4727 8 involving involve VBG cord-005453-4057qib7 4727 9 left leave VBN cord-005453-4057qib7 4727 10 temporal temporal JJ cord-005453-4057qib7 4727 11 region region NN cord-005453-4057qib7 4727 12 that that WDT cord-005453-4057qib7 4727 13 was be VBD cord-005453-4057qib7 4727 14 completely completely RB cord-005453-4057qib7 4727 15 excised excise VBN cord-005453-4057qib7 4727 16 . . . cord-005453-4057qib7 4728 1 Two two CD cord-005453-4057qib7 4728 2 months month NNS cord-005453-4057qib7 4728 3 later later RB cord-005453-4057qib7 4728 4 , , , cord-005453-4057qib7 4728 5 more more JJR cord-005453-4057qib7 4728 6 lesions lesion NNS cord-005453-4057qib7 4728 7 in in IN cord-005453-4057qib7 4728 8 scalp scalp NN cord-005453-4057qib7 4728 9 and and CC cord-005453-4057qib7 4728 10 nose nose NN cord-005453-4057qib7 4728 11 were be VBD cord-005453-4057qib7 4728 12 noted note VBN cord-005453-4057qib7 4728 13 and and CC cord-005453-4057qib7 4728 14 intralesion intralesion NN cord-005453-4057qib7 4728 15 treatment treatment NN cord-005453-4057qib7 4728 16 with with IN cord-005453-4057qib7 4728 17 methotrexate methotrexate NNP cord-005453-4057qib7 4728 18 was be VBD cord-005453-4057qib7 4728 19 started start VBN cord-005453-4057qib7 4728 20 . . . cord-005453-4057qib7 4729 1 However however RB cord-005453-4057qib7 4729 2 , , , cord-005453-4057qib7 4729 3 an an DT cord-005453-4057qib7 4729 4 unfavorable unfavorable JJ cord-005453-4057qib7 4729 5 evolution evolution NN cord-005453-4057qib7 4729 6 was be VBD cord-005453-4057qib7 4729 7 noted note VBN cord-005453-4057qib7 4729 8 and and CC cord-005453-4057qib7 4729 9 he -PRON- PRP cord-005453-4057qib7 4729 10 was be VBD cord-005453-4057qib7 4729 11 put put VBN cord-005453-4057qib7 4729 12 on on IN cord-005453-4057qib7 4729 13 systemic systemic JJ cord-005453-4057qib7 4729 14 treatment treatment NN cord-005453-4057qib7 4729 15 including include VBG cord-005453-4057qib7 4729 16 Cisplatin Cisplatin NNP cord-005453-4057qib7 4729 17 and and CC cord-005453-4057qib7 4729 18 Cetuximab Cetuximab NNP cord-005453-4057qib7 4729 19 receiving receive VBG cord-005453-4057qib7 4729 20 the the DT cord-005453-4057qib7 4729 21 whole whole JJ cord-005453-4057qib7 4729 22 scheme scheme NN cord-005453-4057qib7 4729 23 from from IN cord-005453-4057qib7 4729 24 January January NNP cord-005453-4057qib7 4729 25 to to IN cord-005453-4057qib7 4729 26 March March NNP cord-005453-4057qib7 4729 27 2018 2018 CD cord-005453-4057qib7 4729 28 and and CC cord-005453-4057qib7 4729 29 continuing continue VBG cord-005453-4057qib7 4729 30 only only RB cord-005453-4057qib7 4729 31 with with IN cord-005453-4057qib7 4729 32 Cetuximab Cetuximab NNP cord-005453-4057qib7 4729 33 , , , cord-005453-4057qib7 4729 34 ten ten CD cord-005453-4057qib7 4729 35 doses dose NNS cord-005453-4057qib7 4729 36 in in IN cord-005453-4057qib7 4729 37 total total NN cord-005453-4057qib7 4729 38 , , , cord-005453-4057qib7 4729 39 until until IN cord-005453-4057qib7 4729 40 May May NNP cord-005453-4057qib7 4729 41 , , , cord-005453-4057qib7 4729 42 for for IN cord-005453-4057qib7 4729 43 unaceptable unaceptable JJ cord-005453-4057qib7 4729 44 and and CC cord-005453-4057qib7 4729 45 severe severe JJ cord-005453-4057qib7 4729 46 tubulopathy tubulopathy NNP cord-005453-4057qib7 4729 47 that that WDT cord-005453-4057qib7 4729 48 required require VBD cord-005453-4057qib7 4729 49 admission admission NN cord-005453-4057qib7 4729 50 at at IN cord-005453-4057qib7 4729 51 the the DT cord-005453-4057qib7 4729 52 hospital hospital NN cord-005453-4057qib7 4729 53 in in IN cord-005453-4057qib7 4729 54 several several JJ cord-005453-4057qib7 4729 55 ocassions ocassion NNS cord-005453-4057qib7 4729 56 . . . cord-005453-4057qib7 4730 1 He -PRON- PRP cord-005453-4057qib7 4730 2 achieved achieve VBD cord-005453-4057qib7 4730 3 a a DT cord-005453-4057qib7 4730 4 very very RB cord-005453-4057qib7 4730 5 good good JJ cord-005453-4057qib7 4730 6 partial partial JJ cord-005453-4057qib7 4730 7 response response NN cord-005453-4057qib7 4730 8 but but CC cord-005453-4057qib7 4730 9 progression progression NN cord-005453-4057qib7 4730 10 was be VBD cord-005453-4057qib7 4730 11 noted note VBN cord-005453-4057qib7 4730 12 shortly shortly RB cord-005453-4057qib7 4730 13 in in IN cord-005453-4057qib7 4730 14 follow follow NN cord-005453-4057qib7 4730 15 up up RP cord-005453-4057qib7 4730 16 . . . cord-005453-4057qib7 4731 1 At at IN cord-005453-4057qib7 4731 2 this this DT cord-005453-4057qib7 4731 3 point point NN cord-005453-4057qib7 4731 4 , , , cord-005453-4057qib7 4731 5 non non JJ cord-005453-4057qib7 4731 6 curative curative JJ cord-005453-4057qib7 4731 7 therapeutic therapeutic JJ cord-005453-4057qib7 4731 8 options option NNS cord-005453-4057qib7 4731 9 were be VBD cord-005453-4057qib7 4731 10 found find VBN cord-005453-4057qib7 4731 11 and and CC cord-005453-4057qib7 4731 12 he -PRON- PRP cord-005453-4057qib7 4731 13 was be VBD cord-005453-4057qib7 4731 14 put put VBN cord-005453-4057qib7 4731 15 on on IN cord-005453-4057qib7 4731 16 intralesion intralesion NN cord-005453-4057qib7 4731 17 methotrexate methotrexate NNP cord-005453-4057qib7 4731 18 and and CC cord-005453-4057qib7 4731 19 photodynamic photodynamic NNP cord-005453-4057qib7 4731 20 theraphy theraphy NN cord-005453-4057qib7 4731 21 in in IN cord-005453-4057qib7 4731 22 a a DT cord-005453-4057qib7 4731 23 weekly weekly JJ cord-005453-4057qib7 4731 24 basis basis NN cord-005453-4057qib7 4731 25 with with IN cord-005453-4057qib7 4731 26 palliative palliative JJ cord-005453-4057qib7 4731 27 intention intention NN cord-005453-4057qib7 4731 28 . . . cord-005453-4057qib7 4732 1 Unfortunately unfortunately RB cord-005453-4057qib7 4732 2 , , , cord-005453-4057qib7 4732 3 tumor tumor NN cord-005453-4057qib7 4732 4 growth growth NN cord-005453-4057qib7 4732 5 was be VBD cord-005453-4057qib7 4732 6 fast fast JJ cord-005453-4057qib7 4732 7 and and CC cord-005453-4057qib7 4732 8 patient patient NN cord-005453-4057qib7 4732 9 passed pass VBD cord-005453-4057qib7 4732 10 away away RB cord-005453-4057qib7 4732 11 in in IN cord-005453-4057qib7 4732 12 August August NNP cord-005453-4057qib7 4732 13 2018 2018 CD cord-005453-4057qib7 4732 14 , , , cord-005453-4057qib7 4732 15 fifteen fifteen CD cord-005453-4057qib7 4732 16 months month NNS cord-005453-4057qib7 4732 17 after after IN cord-005453-4057qib7 4732 18 squamous squamous JJ cord-005453-4057qib7 4732 19 cell cell NN cord-005453-4057qib7 4732 20 carcinoma carcinoma NN cord-005453-4057qib7 4732 21 diagnosis diagnosis NN cord-005453-4057qib7 4732 22 , , , cord-005453-4057qib7 4732 23 due due IN cord-005453-4057qib7 4732 24 to to IN cord-005453-4057qib7 4732 25 tumoral tumoral JJ cord-005453-4057qib7 4732 26 progression progression NN cord-005453-4057qib7 4732 27 . . . cord-005453-4057qib7 4733 1 Conclusions conclusion NNS cord-005453-4057qib7 4733 2 : : : cord-005453-4057qib7 4734 1 1 1 LS cord-005453-4057qib7 4734 2 ) ) -RRB- cord-005453-4057qib7 4734 3 SCC SCC NNP cord-005453-4057qib7 4734 4 is be VBZ cord-005453-4057qib7 4734 5 a a DT cord-005453-4057qib7 4734 6 rare rare JJ cord-005453-4057qib7 4734 7 , , , cord-005453-4057qib7 4734 8 non non JJ cord-005453-4057qib7 4734 9 - - JJ cord-005453-4057qib7 4734 10 previously previously RB cord-005453-4057qib7 4734 11 described describe VBN cord-005453-4057qib7 4734 12 , , , cord-005453-4057qib7 4734 13 secondary secondary JJ cord-005453-4057qib7 4734 14 malignancy malignancy NN cord-005453-4057qib7 4734 15 in in IN cord-005453-4057qib7 4734 16 children child NNS cord-005453-4057qib7 4734 17 undergoing undergo VBG cord-005453-4057qib7 4734 18 HSCT HSCT NNP cord-005453-4057qib7 4734 19 . . . cord-005453-4057qib7 4735 1 2 2 LS cord-005453-4057qib7 4735 2 ) ) -RRB- cord-005453-4057qib7 4735 3 High high JJ cord-005453-4057qib7 4735 4 - - HYPH cord-005453-4057qib7 4735 5 risk risk NN cord-005453-4057qib7 4735 6 features feature VBZ cord-005453-4057qib7 4735 7 SCC SCC NNP cord-005453-4057qib7 4735 8 constitutes constitute VBZ cord-005453-4057qib7 4735 9 an an DT cord-005453-4057qib7 4735 10 aggresive aggresive JJ cord-005453-4057qib7 4735 11 disease disease NN cord-005453-4057qib7 4735 12 with with IN cord-005453-4057qib7 4735 13 a a DT cord-005453-4057qib7 4735 14 median median JJ cord-005453-4057qib7 4735 15 overall overall JJ cord-005453-4057qib7 4735 16 survival survival NN cord-005453-4057qib7 4735 17 below below IN cord-005453-4057qib7 4735 18 1 1 CD cord-005453-4057qib7 4735 19 year year NN cord-005453-4057qib7 4735 20 . . . cord-005453-4057qib7 4736 1 3 3 LS cord-005453-4057qib7 4736 2 ) ) -RRB- cord-005453-4057qib7 4736 3 cGVHD cGVHD NNP cord-005453-4057qib7 4736 4 appears appear VBZ cord-005453-4057qib7 4736 5 to to TO cord-005453-4057qib7 4736 6 be be VB cord-005453-4057qib7 4736 7 an an DT cord-005453-4057qib7 4736 8 important important JJ cord-005453-4057qib7 4736 9 risk risk NN cord-005453-4057qib7 4736 10 factor factor NN cord-005453-4057qib7 4736 11 for for IN cord-005453-4057qib7 4736 12 its -PRON- PRP$ cord-005453-4057qib7 4736 13 development development NN cord-005453-4057qib7 4736 14 . . . cord-005453-4057qib7 4737 1 4 4 LS cord-005453-4057qib7 4737 2 ) ) -RRB- cord-005453-4057qib7 4738 1 Voriconazole Voriconazole NNP cord-005453-4057qib7 4738 2 induced induced NN cord-005453-4057qib7 4738 3 - - : cord-005453-4057qib7 4738 4 photosensitivity photosensitivity NN cord-005453-4057qib7 4738 5 might may MD cord-005453-4057qib7 4738 6 have have VB cord-005453-4057qib7 4738 7 played play VBN cord-005453-4057qib7 4738 8 a a DT cord-005453-4057qib7 4738 9 role role NN cord-005453-4057qib7 4738 10 . . . cord-005453-4057qib7 4739 1 5 5 LS cord-005453-4057qib7 4739 2 ) ) -RRB- cord-005453-4057qib7 4740 1 Cisplatin cisplatin NN cord-005453-4057qib7 4740 2 based base VBN cord-005453-4057qib7 4740 3 regimens regimen NNS cord-005453-4057qib7 4740 4 + + CC cord-005453-4057qib7 4741 1 /-Cetuximab /-Cetuximab , cord-005453-4057qib7 4741 2 are be VBP cord-005453-4057qib7 4741 3 a a DT cord-005453-4057qib7 4741 4 therapeutic therapeutic JJ cord-005453-4057qib7 4741 5 option option NN cord-005453-4057qib7 4741 6 in in IN cord-005453-4057qib7 4741 7 disseminated disseminate VBN cord-005453-4057qib7 4741 8 and/or and/or CC cord-005453-4057qib7 4741 9 high high JJ cord-005453-4057qib7 4741 10 risk risk NN cord-005453-4057qib7 4741 11 cases case NNS cord-005453-4057qib7 4741 12 . . . cord-005453-4057qib7 4742 1 As as IN cord-005453-4057qib7 4742 2 outcomes outcome NNS cord-005453-4057qib7 4742 3 are be VBP cord-005453-4057qib7 4742 4 unsatisfactory unsatisfactory JJ cord-005453-4057qib7 4742 5 in in IN cord-005453-4057qib7 4742 6 these these DT cord-005453-4057qib7 4742 7 cases case NNS cord-005453-4057qib7 4742 8 , , , cord-005453-4057qib7 4742 9 alternative alternative JJ cord-005453-4057qib7 4742 10 therapeutic therapeutic JJ cord-005453-4057qib7 4742 11 options option NNS cord-005453-4057qib7 4742 12 need need VBP cord-005453-4057qib7 4742 13 to to TO cord-005453-4057qib7 4742 14 be be VB cord-005453-4057qib7 4742 15 explored explore VBN cord-005453-4057qib7 4742 16 . . . cord-005453-4057qib7 4743 1 Disclosure disclosure NN cord-005453-4057qib7 4743 2 Background background NN cord-005453-4057qib7 4743 3 : : : cord-005453-4057qib7 4743 4 Pregnancy pregnancy NN cord-005453-4057qib7 4743 5 is be VBZ cord-005453-4057qib7 4743 6 a a DT cord-005453-4057qib7 4743 7 rare rare JJ cord-005453-4057qib7 4743 8 event event NN cord-005453-4057qib7 4743 9 after after IN cord-005453-4057qib7 4743 10 allogeneic allogeneic NN cord-005453-4057qib7 4743 11 stem stem NN cord-005453-4057qib7 4743 12 cell cell NN cord-005453-4057qib7 4743 13 transplantation transplantation NN cord-005453-4057qib7 4743 14 ( ( -LRB- cord-005453-4057qib7 4743 15 SCT SCT NNP cord-005453-4057qib7 4743 16 ) ) -RRB- cord-005453-4057qib7 4743 17 for for IN cord-005453-4057qib7 4743 18 acute acute JJ cord-005453-4057qib7 4743 19 leukemia leukemia NN cord-005453-4057qib7 4743 20 . . . cord-005453-4057qib7 4744 1 Here here RB cord-005453-4057qib7 4744 2 we -PRON- PRP cord-005453-4057qib7 4744 3 report report VBP cord-005453-4057qib7 4744 4 , , , cord-005453-4057qib7 4744 5 to to IN cord-005453-4057qib7 4744 6 the the DT cord-005453-4057qib7 4744 7 best good JJS cord-005453-4057qib7 4744 8 of of IN cord-005453-4057qib7 4744 9 our -PRON- PRP$ cord-005453-4057qib7 4744 10 knowledge knowledge NN cord-005453-4057qib7 4744 11 , , , cord-005453-4057qib7 4744 12 for for IN cord-005453-4057qib7 4744 13 the the DT cord-005453-4057qib7 4744 14 first first JJ cord-005453-4057qib7 4744 15 time time NN cord-005453-4057qib7 4744 16 on on IN cord-005453-4057qib7 4744 17 a a DT cord-005453-4057qib7 4744 18 successful successful JJ cord-005453-4057qib7 4744 19 pregnancy pregnancy NN cord-005453-4057qib7 4744 20 after after IN cord-005453-4057qib7 4744 21 treosulfan treosulfan NNP cord-005453-4057qib7 4744 22 - - HYPH cord-005453-4057qib7 4744 23 based base VBN cord-005453-4057qib7 4744 24 conditioning conditioning NN cord-005453-4057qib7 4744 25 . . . cord-005453-4057qib7 4745 1 Methods method NNS cord-005453-4057qib7 4745 2 : : : cord-005453-4057qib7 4746 1 A a DT cord-005453-4057qib7 4746 2 29-year 29-year JJ cord-005453-4057qib7 4746 3 old old JJ cord-005453-4057qib7 4746 4 woman woman NN cord-005453-4057qib7 4746 5 was be VBD cord-005453-4057qib7 4746 6 diagnosed diagnose VBN cord-005453-4057qib7 4746 7 with with IN cord-005453-4057qib7 4746 8 acute acute JJ cord-005453-4057qib7 4746 9 myeloid myeloid NN cord-005453-4057qib7 4746 10 leukemia leukemia NN cord-005453-4057qib7 4746 11 ( ( -LRB- cord-005453-4057qib7 4746 12 AML AML NNP cord-005453-4057qib7 4746 13 ) ) -RRB- cord-005453-4057qib7 4746 14 secondary secondary JJ cord-005453-4057qib7 4746 15 to to IN cord-005453-4057qib7 4746 16 chronic chronic JJ cord-005453-4057qib7 4746 17 myelomonocytic myelomonocytic JJ cord-005453-4057qib7 4746 18 leukemia leukemia NN cord-005453-4057qib7 4746 19 in in IN cord-005453-4057qib7 4746 20 July July NNP cord-005453-4057qib7 4746 21 2015 2015 CD cord-005453-4057qib7 4746 22 . . . cord-005453-4057qib7 4747 1 Ovarian ovarian JJ cord-005453-4057qib7 4747 2 preservation preservation NN cord-005453-4057qib7 4747 3 was be VBD cord-005453-4057qib7 4747 4 performed perform VBN cord-005453-4057qib7 4747 5 by by IN cord-005453-4057qib7 4747 6 leuprolide leuprolide JJ cord-005453-4057qib7 4747 7 acetate acetate NN cord-005453-4057qib7 4747 8 depot depot NN cord-005453-4057qib7 4747 9 injection injection NN cord-005453-4057qib7 4747 10 prior prior RB cord-005453-4057qib7 4747 11 to to IN cord-005453-4057qib7 4747 12 cytostatic cytostatic JJ cord-005453-4057qib7 4747 13 chemotherapy chemotherapy NN cord-005453-4057qib7 4747 14 . . . cord-005453-4057qib7 4748 1 Of of IN cord-005453-4057qib7 4748 2 note note VB cord-005453-4057qib7 4748 3 , , , cord-005453-4057qib7 4748 4 no no DT cord-005453-4057qib7 4748 5 cryopreservation cryopreservation NN cord-005453-4057qib7 4748 6 of of IN cord-005453-4057qib7 4748 7 oocytes oocyte NNS cord-005453-4057qib7 4748 8 or or CC cord-005453-4057qib7 4748 9 ovarian ovarian JJ cord-005453-4057qib7 4748 10 tissue tissue NN cord-005453-4057qib7 4748 11 was be VBD cord-005453-4057qib7 4748 12 conducted conduct VBN cord-005453-4057qib7 4748 13 . . . cord-005453-4057qib7 4749 1 She -PRON- PRP cord-005453-4057qib7 4749 2 received receive VBD cord-005453-4057qib7 4749 3 two two CD cord-005453-4057qib7 4749 4 cycles cycle NNS cord-005453-4057qib7 4749 5 of of IN cord-005453-4057qib7 4749 6 chemotherapy chemotherapy NN cord-005453-4057qib7 4749 7 consisting consist VBG cord-005453-4057qib7 4749 8 of of IN cord-005453-4057qib7 4749 9 idarubicine idarubicine NNP cord-005453-4057qib7 4749 10 ( ( -LRB- cord-005453-4057qib7 4749 11 12mg 12mg NNP cord-005453-4057qib7 4749 12 / / SYM cord-005453-4057qib7 4749 13 m² m² NNP cord-005453-4057qib7 4749 14 on on IN cord-005453-4057qib7 4749 15 day day NN cord-005453-4057qib7 4749 16 1 1 CD cord-005453-4057qib7 4749 17 - - SYM cord-005453-4057qib7 4749 18 3 3 CD cord-005453-4057qib7 4749 19 ) ) -RRB- cord-005453-4057qib7 4749 20 and and CC cord-005453-4057qib7 4749 21 cytarabine cytarabine NNP cord-005453-4057qib7 4749 22 ( ( -LRB- cord-005453-4057qib7 4749 23 1000mg 1000mg NNP cord-005453-4057qib7 4749 24 / / SYM cord-005453-4057qib7 4749 25 m² m² NN cord-005453-4057qib7 4749 26 b.i.d b.i.d NN cord-005453-4057qib7 4749 27 . . . cord-005453-4057qib7 4750 1 on on IN cord-005453-4057qib7 4750 2 days day NNS cord-005453-4057qib7 4750 3 1 1 CD cord-005453-4057qib7 4750 4 , , , cord-005453-4057qib7 4750 5 3 3 CD cord-005453-4057qib7 4750 6 , , , cord-005453-4057qib7 4750 7 5 5 CD cord-005453-4057qib7 4750 8 and and CC cord-005453-4057qib7 4750 9 7 7 CD cord-005453-4057qib7 4750 10 ) ) -RRB- cord-005453-4057qib7 4750 11 . . . cord-005453-4057qib7 4751 1 Due due IN cord-005453-4057qib7 4751 2 to to IN cord-005453-4057qib7 4751 3 secondary secondary JJ cord-005453-4057qib7 4751 4 origin origin NN cord-005453-4057qib7 4751 5 of of IN cord-005453-4057qib7 4751 6 AML AML NNP cord-005453-4057qib7 4751 7 SCT SCT NNP cord-005453-4057qib7 4751 8 was be VBD cord-005453-4057qib7 4751 9 performed perform VBN cord-005453-4057qib7 4751 10 in in IN cord-005453-4057qib7 4751 11 first first JJ cord-005453-4057qib7 4751 12 complete complete JJ cord-005453-4057qib7 4751 13 remission remission NN cord-005453-4057qib7 4751 14 of of IN cord-005453-4057qib7 4751 15 AML AML NNP cord-005453-4057qib7 4751 16 after after IN cord-005453-4057qib7 4751 17 conditioning condition VBG cord-005453-4057qib7 4751 18 with with IN cord-005453-4057qib7 4751 19 treosulfan treosulfan NNP cord-005453-4057qib7 4751 20 ( ( -LRB- cord-005453-4057qib7 4751 21 14g/ 14g/ CD cord-005453-4057qib7 4751 22 m² m² NN cord-005453-4057qib7 4751 23 days day NNS cord-005453-4057qib7 4751 24 3 3 CD cord-005453-4057qib7 4751 25 - - SYM cord-005453-4057qib7 4751 26 5 5 CD cord-005453-4057qib7 4751 27 ) ) -RRB- cord-005453-4057qib7 4751 28 and and CC cord-005453-4057qib7 4751 29 fludarabine fludarabine NNP cord-005453-4057qib7 4751 30 ( ( -LRB- cord-005453-4057qib7 4751 31 30mg 30mg NNP cord-005453-4057qib7 4751 32 / / SYM cord-005453-4057qib7 4751 33 m² m² NN cord-005453-4057qib7 4751 34 days day NNS cord-005453-4057qib7 4751 35 1 1 CD cord-005453-4057qib7 4751 36 - - SYM cord-005453-4057qib7 4751 37 5 5 CD cord-005453-4057qib7 4751 38 ) ) -RRB- cord-005453-4057qib7 4751 39 . . . cord-005453-4057qib7 4752 1 She -PRON- PRP cord-005453-4057qib7 4752 2 received receive VBD cord-005453-4057qib7 4752 3 4.94×10 4.94×10 CD cord-005453-4057qib7 4752 4 6 6 CD cord-005453-4057qib7 4752 5 CD34-positive cd34-positive CD cord-005453-4057qib7 4752 6 cells cell NNS cord-005453-4057qib7 4752 7 per per IN cord-005453-4057qib7 4752 8 kilogram kilogram NN cord-005453-4057qib7 4752 9 body body NN cord-005453-4057qib7 4752 10 weight weight NN cord-005453-4057qib7 4752 11 from from IN cord-005453-4057qib7 4752 12 a a DT cord-005453-4057qib7 4752 13 HLA HLA NNP cord-005453-4057qib7 4752 14 - - HYPH cord-005453-4057qib7 4752 15 matched match VBN cord-005453-4057qib7 4752 16 unrelated unrelated JJ cord-005453-4057qib7 4752 17 donor donor NN cord-005453-4057qib7 4752 18 . . . cord-005453-4057qib7 4753 1 Results result NNS cord-005453-4057qib7 4753 2 : : : cord-005453-4057qib7 4754 1 Follow follow VB cord-005453-4057qib7 4754 2 - - HYPH cord-005453-4057qib7 4754 3 up up RP cord-005453-4057qib7 4754 4 bone bone NN cord-005453-4057qib7 4754 5 marrow marrow NN cord-005453-4057qib7 4754 6 aspirates aspirate NNS cord-005453-4057qib7 4754 7 showed show VBD cord-005453-4057qib7 4754 8 continuous continuous JJ cord-005453-4057qib7 4754 9 complete complete JJ cord-005453-4057qib7 4754 10 remission remission NN cord-005453-4057qib7 4754 11 of of IN cord-005453-4057qib7 4754 12 AML AML NNP cord-005453-4057qib7 4754 13 . . . cord-005453-4057qib7 4755 1 Seven seven CD cord-005453-4057qib7 4755 2 months month NNS cord-005453-4057qib7 4755 3 after after IN cord-005453-4057qib7 4755 4 SCT SCT NNP cord-005453-4057qib7 4755 5 she -PRON- PRP cord-005453-4057qib7 4755 6 became become VBD cord-005453-4057qib7 4755 7 pregnant pregnant JJ cord-005453-4057qib7 4755 8 , , , cord-005453-4057qib7 4755 9 but but CC cord-005453-4057qib7 4755 10 decided decide VBD cord-005453-4057qib7 4755 11 for for IN cord-005453-4057qib7 4755 12 induced induce VBN cord-005453-4057qib7 4755 13 abortion abortion NN cord-005453-4057qib7 4755 14 . . . cord-005453-4057qib7 4756 1 In in IN cord-005453-4057qib7 4756 2 January January NNP cord-005453-4057qib7 4756 3 2018 2018 CD cord-005453-4057qib7 4756 4 , , , cord-005453-4057qib7 4756 5 25 25 CD cord-005453-4057qib7 4756 6 months month NNS cord-005453-4057qib7 4756 7 after after IN cord-005453-4057qib7 4756 8 HSCT HSCT NNP cord-005453-4057qib7 4756 9 she -PRON- PRP cord-005453-4057qib7 4756 10 became become VBD cord-005453-4057qib7 4756 11 pregnant pregnant JJ cord-005453-4057qib7 4756 12 again again RB cord-005453-4057qib7 4756 13 and and CC cord-005453-4057qib7 4756 14 desired desire VBD cord-005453-4057qib7 4756 15 the the DT cord-005453-4057qib7 4756 16 child child NN cord-005453-4057qib7 4756 17 . . . cord-005453-4057qib7 4757 1 Medical medical JJ cord-005453-4057qib7 4757 2 examinations examination NNS cord-005453-4057qib7 4757 3 were be VBD cord-005453-4057qib7 4757 4 performed perform VBN cord-005453-4057qib7 4757 5 monthly monthly RB cord-005453-4057qib7 4757 6 on on IN cord-005453-4057qib7 4757 7 an an DT cord-005453-4057qib7 4757 8 outpatient outpatient NN cord-005453-4057qib7 4757 9 basis basis NN cord-005453-4057qib7 4757 10 in in IN cord-005453-4057qib7 4757 11 stringent stringent JJ cord-005453-4057qib7 4757 12 cooperation cooperation NN cord-005453-4057qib7 4757 13 with with IN cord-005453-4057qib7 4757 14 the the DT cord-005453-4057qib7 4757 15 maternity maternity NN cord-005453-4057qib7 4757 16 clinic clinic NN cord-005453-4057qib7 4757 17 . . . cord-005453-4057qib7 4758 1 The the DT cord-005453-4057qib7 4758 2 course course NN cord-005453-4057qib7 4758 3 of of IN cord-005453-4057qib7 4758 4 pregnancy pregnancy NN cord-005453-4057qib7 4758 5 was be VBD cord-005453-4057qib7 4758 6 unremarkable unremarkable JJ cord-005453-4057qib7 4758 7 , , , cord-005453-4057qib7 4758 8 although although IN cord-005453-4057qib7 4758 9 she -PRON- PRP cord-005453-4057qib7 4758 10 was be VBD cord-005453-4057qib7 4758 11 hospitalized hospitalize VBN cord-005453-4057qib7 4758 12 due due IN cord-005453-4057qib7 4758 13 to to IN cord-005453-4057qib7 4758 14 premature premature JJ cord-005453-4057qib7 4758 15 labor labor NN cord-005453-4057qib7 4758 16 in in IN cord-005453-4057qib7 4758 17 the the DT cord-005453-4057qib7 4758 18 34 34 CD cord-005453-4057qib7 4758 19 th th CD cord-005453-4057qib7 4758 20 week week NN cord-005453-4057qib7 4758 21 of of IN cord-005453-4057qib7 4758 22 pregnancy pregnancy NN cord-005453-4057qib7 4758 23 . . . cord-005453-4057qib7 4759 1 However however RB cord-005453-4057qib7 4759 2 , , , cord-005453-4057qib7 4759 3 gynecological gynecological JJ cord-005453-4057qib7 4759 4 examination examination NN cord-005453-4057qib7 4759 5 showed show VBD cord-005453-4057qib7 4759 6 no no DT cord-005453-4057qib7 4759 7 clinical clinical JJ cord-005453-4057qib7 4759 8 significant significant JJ cord-005453-4057qib7 4759 9 findings finding NNS cord-005453-4057qib7 4759 10 , , , cord-005453-4057qib7 4759 11 so so IN cord-005453-4057qib7 4759 12 that that DT cord-005453-4057qib7 4759 13 section section NN cord-005453-4057qib7 4759 14 was be VBD cord-005453-4057qib7 4759 15 planned plan VBN cord-005453-4057qib7 4760 1 and and CC cord-005453-4057qib7 4760 2 she -PRON- PRP cord-005453-4057qib7 4760 3 could could MD cord-005453-4057qib7 4760 4 be be VB cord-005453-4057qib7 4760 5 discharged discharge VBN cord-005453-4057qib7 4760 6 again again RB cord-005453-4057qib7 4760 7 . . . cord-005453-4057qib7 4761 1 In in IN cord-005453-4057qib7 4761 2 the the DT cord-005453-4057qib7 4761 3 38 38 CD cord-005453-4057qib7 4761 4 th th CD cord-005453-4057qib7 4761 5 week week NN cord-005453-4057qib7 4761 6 of of IN cord-005453-4057qib7 4761 7 pregnancy pregnancy NN cord-005453-4057qib7 4761 8 she -PRON- PRP cord-005453-4057qib7 4761 9 gave give VBD cord-005453-4057qib7 4761 10 birth birth NN cord-005453-4057qib7 4761 11 to to IN cord-005453-4057qib7 4761 12 a a DT cord-005453-4057qib7 4761 13 healthy healthy JJ cord-005453-4057qib7 4761 14 girl girl NN cord-005453-4057qib7 4761 15 ( ( -LRB- cord-005453-4057qib7 4761 16 50 50 CD cord-005453-4057qib7 4761 17 cm cm NNS cord-005453-4057qib7 4761 18 , , , cord-005453-4057qib7 4761 19 2810 2810 CD cord-005453-4057qib7 4761 20 g g NN cord-005453-4057qib7 4761 21 ) ) -RRB- cord-005453-4057qib7 4761 22 by by IN cord-005453-4057qib7 4761 23 cesarean cesarean NN cord-005453-4057qib7 4761 24 section section NN cord-005453-4057qib7 4761 25 . . . cord-005453-4057qib7 4762 1 Peripartum Peripartum NNP cord-005453-4057qib7 4762 2 she -PRON- PRP cord-005453-4057qib7 4762 3 developed develop VBD cord-005453-4057qib7 4762 4 hypoethesia hypoethesia NNP cord-005453-4057qib7 4762 5 of of IN cord-005453-4057qib7 4762 6 the the DT cord-005453-4057qib7 4762 7 left left JJ cord-005453-4057qib7 4762 8 body body NN cord-005453-4057qib7 4762 9 half half NN cord-005453-4057qib7 4762 10 . . . cord-005453-4057qib7 4763 1 Neurological neurological JJ cord-005453-4057qib7 4763 2 examination examination NN cord-005453-4057qib7 4763 3 showed show VBD cord-005453-4057qib7 4763 4 no no DT cord-005453-4057qib7 4763 5 abnormalities abnormality NNS cord-005453-4057qib7 4763 6 and and CC cord-005453-4057qib7 4763 7 she -PRON- PRP cord-005453-4057qib7 4763 8 recovered recover VBD cord-005453-4057qib7 4763 9 immediately immediately RB cord-005453-4057qib7 4763 10 . . . cord-005453-4057qib7 4764 1 There there EX cord-005453-4057qib7 4764 2 were be VBD cord-005453-4057qib7 4764 3 no no DT cord-005453-4057qib7 4764 4 other other JJ cord-005453-4057qib7 4764 5 postpartum postpartum NN cord-005453-4057qib7 4764 6 complications complication NNS cord-005453-4057qib7 4764 7 . . . cord-005453-4057qib7 4765 1 Breastfeeding breastfeeding NN cord-005453-4057qib7 4765 2 was be VBD cord-005453-4057qib7 4765 3 established establish VBN cord-005453-4057qib7 4765 4 but but CC cord-005453-4057qib7 4765 5 additional additional JJ cord-005453-4057qib7 4765 6 food food NN cord-005453-4057qib7 4765 7 was be VBD cord-005453-4057qib7 4765 8 necessary necessary JJ cord-005453-4057qib7 4765 9 for for IN cord-005453-4057qib7 4765 10 a a DT cord-005453-4057qib7 4765 11 sufficient sufficient JJ cord-005453-4057qib7 4765 12 nutrition nutrition NN cord-005453-4057qib7 4765 13 of of IN cord-005453-4057qib7 4765 14 the the DT cord-005453-4057qib7 4765 15 child child NN cord-005453-4057qib7 4765 16 . . . cord-005453-4057qib7 4766 1 Conclusions conclusion NNS cord-005453-4057qib7 4766 2 : : : cord-005453-4057qib7 4767 1 This this DT cord-005453-4057qib7 4767 2 case case NN cord-005453-4057qib7 4767 3 of of IN cord-005453-4057qib7 4767 4 successful successful JJ cord-005453-4057qib7 4767 5 pregnancy pregnancy NN cord-005453-4057qib7 4767 6 following follow VBG cord-005453-4057qib7 4767 7 SCT SCT NNP cord-005453-4057qib7 4767 8 demonstrates demonstrate VBZ cord-005453-4057qib7 4767 9 that that IN cord-005453-4057qib7 4767 10 fertility fertility NN cord-005453-4057qib7 4767 11 can can MD cord-005453-4057qib7 4767 12 recover recover VB cord-005453-4057qib7 4767 13 after after IN cord-005453-4057qib7 4767 14 treosulfan treosulfan NNP cord-005453-4057qib7 4767 15 - - HYPH cord-005453-4057qib7 4767 16 based base VBN cord-005453-4057qib7 4767 17 conditioning conditioning NN cord-005453-4057qib7 4767 18 . . . cord-005453-4057qib7 4768 1 However however RB cord-005453-4057qib7 4768 2 , , , cord-005453-4057qib7 4768 3 detailed detailed JJ cord-005453-4057qib7 4768 4 studies study NNS cord-005453-4057qib7 4768 5 of of IN cord-005453-4057qib7 4768 6 ovarian ovarian JJ cord-005453-4057qib7 4768 7 function function NN cord-005453-4057qib7 4768 8 and and CC cord-005453-4057qib7 4768 9 fertility fertility NN cord-005453-4057qib7 4768 10 are be VBP cord-005453-4057qib7 4768 11 necessary necessary JJ cord-005453-4057qib7 4768 12 to to TO cord-005453-4057qib7 4768 13 gain gain VB cord-005453-4057qib7 4768 14 more more JJR cord-005453-4057qib7 4768 15 insight insight NN cord-005453-4057qib7 4768 16 into into IN cord-005453-4057qib7 4768 17 the the DT cord-005453-4057qib7 4768 18 risk risk NN cord-005453-4057qib7 4768 19 of of IN cord-005453-4057qib7 4768 20 premature premature JJ cord-005453-4057qib7 4768 21 ovarian ovarian JJ cord-005453-4057qib7 4768 22 failure failure NN cord-005453-4057qib7 4768 23 . . . cord-005453-4057qib7 4769 1 Disclosure disclosure NN cord-005453-4057qib7 4769 2 : : : cord-005453-4057qib7 4769 3 Nothing nothing NN cord-005453-4057qib7 4769 4 to to TO cord-005453-4057qib7 4769 5 declare declare VB cord-005453-4057qib7 4769 6 . . . cord-005453-4057qib7 4770 1 Experimental experimental JJ cord-005453-4057qib7 4770 2 stem stem NN cord-005453-4057qib7 4770 3 cell cell NN cord-005453-4057qib7 4770 4 transplantation transplantation NN cord-005453-4057qib7 4770 5 P219 P219 VBZ cord-005453-4057qib7 4770 6 CD19-cart cd19-cart CD cord-005453-4057qib7 4770 7 therapy therapy NN cord-005453-4057qib7 4770 8 before before IN cord-005453-4057qib7 4770 9 allo allo NN cord-005453-4057qib7 4770 10 - - HYPH cord-005453-4057qib7 4770 11 HSCT HSCT NNP cord-005453-4057qib7 4770 12 in in IN cord-005453-4057qib7 4770 13 children child NNS cord-005453-4057qib7 4770 14 and and CC cord-005453-4057qib7 4770 15 adolescents adolescent NNS cord-005453-4057qib7 4770 16 patients patient NNS cord-005453-4057qib7 4770 17 who who WP cord-005453-4057qib7 4770 18 diagnosed diagnose VBD cord-005453-4057qib7 4770 19 R r NN cord-005453-4057qib7 4770 20 / / SYM cord-005453-4057qib7 4770 21 R r NN cord-005453-4057qib7 4770 22 B b NN cord-005453-4057qib7 4770 23 - - , cord-005453-4057qib7 4770 24 all all DT cord-005453-4057qib7 4770 25 with with IN cord-005453-4057qib7 4770 26 E2A e2a FW cord-005453-4057qib7 4770 27 - - HYPH cord-005453-4057qib7 4770 28 PBX1 PBX1 NNP cord-005453-4057qib7 4770 29 Background Background NNP cord-005453-4057qib7 4770 30 : : : cord-005453-4057qib7 4771 1 B b LS cord-005453-4057qib7 4771 2 - - : cord-005453-4057qib7 4771 3 ALL all DT cord-005453-4057qib7 4771 4 with with IN cord-005453-4057qib7 4771 5 E2A e2a FW cord-005453-4057qib7 4771 6 - - HYPH cord-005453-4057qib7 4771 7 PBX1 PBX1 NNP cord-005453-4057qib7 4771 8 in in IN cord-005453-4057qib7 4771 9 children child NNS cord-005453-4057qib7 4771 10 and and CC cord-005453-4057qib7 4771 11 adolescents adolescent NNS cord-005453-4057qib7 4771 12 is be VBZ cord-005453-4057qib7 4771 13 described describe VBN cord-005453-4057qib7 4771 14 with with IN cord-005453-4057qib7 4771 15 favourable favourable JJ cord-005453-4057qib7 4771 16 prognosis prognosis NN cord-005453-4057qib7 4771 17 . . . cord-005453-4057qib7 4772 1 But but CC cord-005453-4057qib7 4772 2 there there EX cord-005453-4057qib7 4772 3 are be VBP cord-005453-4057qib7 4772 4 more more JJR cord-005453-4057qib7 4772 5 than than IN cord-005453-4057qib7 4772 6 10 10 CD cord-005453-4057qib7 4772 7 % % NN cord-005453-4057qib7 4772 8 patients patient NNS cord-005453-4057qib7 4772 9 with with IN cord-005453-4057qib7 4772 10 E2A e2a NN cord-005453-4057qib7 4772 11 - - HYPH cord-005453-4057qib7 4772 12 PBX1 PBX1 NNP cord-005453-4057qib7 4772 13 diagnosed diagnose VBD cord-005453-4057qib7 4772 14 as as IN cord-005453-4057qib7 4772 15 relapsed relapse VBN cord-005453-4057qib7 4772 16 or or CC cord-005453-4057qib7 4772 17 refractory refractory JJ cord-005453-4057qib7 4772 18 . . . cord-005453-4057qib7 4773 1 The the DT cord-005453-4057qib7 4773 2 results result NNS cord-005453-4057qib7 4773 3 of of IN cord-005453-4057qib7 4773 4 Allo Allo NNP cord-005453-4057qib7 4773 5 - - HYPH cord-005453-4057qib7 4773 6 HSCT HSCT NNP cord-005453-4057qib7 4773 7 in in IN cord-005453-4057qib7 4773 8 children child NNS cord-005453-4057qib7 4773 9 and and CC cord-005453-4057qib7 4773 10 adolescents adolescent NNS cord-005453-4057qib7 4773 11 with with IN cord-005453-4057qib7 4773 12 this this DT cord-005453-4057qib7 4773 13 group group NN cord-005453-4057qib7 4773 14 leukemia leukemia NN cord-005453-4057qib7 4773 15 in in IN cord-005453-4057qib7 4773 16 our -PRON- PRP$ cord-005453-4057qib7 4773 17 center center NN cord-005453-4057qib7 4773 18 was be VBD cord-005453-4057qib7 4773 19 analyzed analyze VBN cord-005453-4057qib7 4773 20 in in IN cord-005453-4057qib7 4773 21 order order NN cord-005453-4057qib7 4773 22 to to TO cord-005453-4057qib7 4773 23 understand understand VB cord-005453-4057qib7 4773 24 the the DT cord-005453-4057qib7 4773 25 therapeutic therapeutic JJ cord-005453-4057qib7 4773 26 effect effect NN cord-005453-4057qib7 4773 27 of of IN cord-005453-4057qib7 4773 28 CD19-CART CD19-CART NNP cord-005453-4057qib7 4773 29 on on IN cord-005453-4057qib7 4773 30 the the DT cord-005453-4057qib7 4773 31 patients patient NNS cord-005453-4057qib7 4773 32 . . . cord-005453-4057qib7 4774 1 Methods method NNS cord-005453-4057qib7 4774 2 : : : cord-005453-4057qib7 4774 3 Retrospective retrospective JJ cord-005453-4057qib7 4774 4 analysis analysis NN cord-005453-4057qib7 4774 5 , , , cord-005453-4057qib7 4774 6 from from IN cord-005453-4057qib7 4774 7 June June NNP cord-005453-4057qib7 4774 8 1st 1st NN cord-005453-4057qib7 4774 9 , , , cord-005453-4057qib7 4774 10 2012 2012 CD cord-005453-4057qib7 4774 11 to to IN cord-005453-4057qib7 4774 12 July July NNP cord-005453-4057qib7 4774 13 31,2018 31,2018 NNP cord-005453-4057qib7 4774 14 , , , cord-005453-4057qib7 4774 15 all all DT cord-005453-4057qib7 4774 16 children child NNS cord-005453-4057qib7 4774 17 and and CC cord-005453-4057qib7 4774 18 adolescents adolescent NNS cord-005453-4057qib7 4774 19 diagnosed diagnose VBD cord-005453-4057qib7 4774 20 relapse relapse NN cord-005453-4057qib7 4774 21 or or CC cord-005453-4057qib7 4774 22 refractory refractory JJ cord-005453-4057qib7 4774 23 B b NN cord-005453-4057qib7 4774 24 - - , cord-005453-4057qib7 4774 25 ALL all DT cord-005453-4057qib7 4774 26 with with IN cord-005453-4057qib7 4774 27 E2A e2a FW cord-005453-4057qib7 4774 28 - - HYPH cord-005453-4057qib7 4774 29 PBX1 PBX1 NNP cord-005453-4057qib7 4774 30 who who WP cord-005453-4057qib7 4774 31 received receive VBD cord-005453-4057qib7 4774 32 Allo Allo NNP cord-005453-4057qib7 4774 33 - - HYPH cord-005453-4057qib7 4774 34 HSCT HSCT NNP cord-005453-4057qib7 4774 35 , , , cord-005453-4057qib7 4774 36 total total JJ cord-005453-4057qib7 4774 37 30 30 CD cord-005453-4057qib7 4774 38 cases case NNS cord-005453-4057qib7 4774 39 . . . cord-005453-4057qib7 4775 1 All all DT cord-005453-4057qib7 4775 2 patients patient NNS cord-005453-4057qib7 4775 3 was be VBD cord-005453-4057qib7 4775 4 divided divide VBN cord-005453-4057qib7 4775 5 into into IN cord-005453-4057qib7 4775 6 two two CD cord-005453-4057qib7 4775 7 groups group NNS cord-005453-4057qib7 4775 8 depending depend VBG cord-005453-4057qib7 4775 9 on on IN cord-005453-4057qib7 4775 10 whether whether IN cord-005453-4057qib7 4775 11 or or CC cord-005453-4057qib7 4775 12 not not RB cord-005453-4057qib7 4775 13 accepted accept VBN cord-005453-4057qib7 4775 14 CD19-CART CD19-CART NNP cord-005453-4057qib7 4775 15 before before IN cord-005453-4057qib7 4775 16 Allo Allo NNP cord-005453-4057qib7 4775 17 - - HYPH cord-005453-4057qib7 4775 18 HSCT HSCT NNP cord-005453-4057qib7 4775 19 . . . cord-005453-4057qib7 4776 1 According accord VBG cord-005453-4057qib7 4776 2 to to IN cord-005453-4057qib7 4776 3 FCM FCM NNP cord-005453-4057qib7 4776 4 - - HYPH cord-005453-4057qib7 4776 5 MRD MRD NNP cord-005453-4057qib7 4776 6 and and CC cord-005453-4057qib7 4776 7 E2A e2a JJ cord-005453-4057qib7 4776 8 - - HYPH cord-005453-4057qib7 4776 9 PBX1 PBX1 NNP cord-005453-4057qib7 4776 10 level level NN cord-005453-4057qib7 4776 11 before before IN cord-005453-4057qib7 4776 12 Allo Allo NNP cord-005453-4057qib7 4776 13 - - HYPH cord-005453-4057qib7 4776 14 HSCT HSCT NNP cord-005453-4057qib7 4776 15 , , , cord-005453-4057qib7 4776 16 OS OS NNP cord-005453-4057qib7 4776 17 LFS lfs NN cord-005453-4057qib7 4776 18 and and CC cord-005453-4057qib7 4776 19 cumulative cumulative JJ cord-005453-4057qib7 4776 20 recurrence recurrence NN cord-005453-4057qib7 4776 21 rate rate NN cord-005453-4057qib7 4776 22 were be VBD cord-005453-4057qib7 4776 23 analyzed analyze VBN cord-005453-4057qib7 4776 24 . . . cord-005453-4057qib7 4777 1 R R NNP cord-005453-4057qib7 4777 2 3.2.0 3.2.0 CD cord-005453-4057qib7 4777 3 was be VBD cord-005453-4057qib7 4777 4 used use VBN cord-005453-4057qib7 4777 5 as as IN cord-005453-4057qib7 4777 6 Statistical statistical JJ cord-005453-4057qib7 4777 7 analysis analysis NN cord-005453-4057qib7 4777 8 software software NN cord-005453-4057qib7 4777 9 . . . cord-005453-4057qib7 4778 1 Results result NNS cord-005453-4057qib7 4778 2 Conclusions conclusion NNS cord-005453-4057qib7 4778 3 : : : cord-005453-4057qib7 4778 4 1 1 CD cord-005453-4057qib7 4778 5 . . . cord-005453-4057qib7 4779 1 For for IN cord-005453-4057qib7 4779 2 R r NN cord-005453-4057qib7 4779 3 / / SYM cord-005453-4057qib7 4779 4 R r NN cord-005453-4057qib7 4779 5 B b NN cord-005453-4057qib7 4779 6 - - , cord-005453-4057qib7 4779 7 ALL all RB cord-005453-4057qib7 4779 8 with with IN cord-005453-4057qib7 4779 9 E2A e2a FW cord-005453-4057qib7 4779 10 - - HYPH cord-005453-4057qib7 4779 11 PBX1 PBX1 NNP cord-005453-4057qib7 4779 12 in in IN cord-005453-4057qib7 4779 13 children child NNS cord-005453-4057qib7 4779 14 and and CC cord-005453-4057qib7 4779 15 adolescents adolescent NNS cord-005453-4057qib7 4779 16 , , , cord-005453-4057qib7 4779 17 FCM FCM NNP cord-005453-4057qib7 4779 18 - - HYPH cord-005453-4057qib7 4779 19 MRD MRD NNP cord-005453-4057qib7 4779 20 pre pre JJ cord-005453-4057qib7 4779 21 - - NN cord-005453-4057qib7 4779 22 transplant transplant NN cord-005453-4057qib7 4779 23 has have VBZ cord-005453-4057qib7 4779 24 n't not RB cord-005453-4057qib7 4779 25 obvious obvious JJ cord-005453-4057qib7 4779 26 effect effect NN cord-005453-4057qib7 4779 27 on on IN cord-005453-4057qib7 4779 28 the the DT cord-005453-4057qib7 4779 29 outcome outcome NN cord-005453-4057qib7 4779 30 of of IN cord-005453-4057qib7 4779 31 Allo Allo NNP cord-005453-4057qib7 4779 32 - - HYPH cord-005453-4057qib7 4779 33 HSCT HSCT NNP cord-005453-4057qib7 4779 34 , , , cord-005453-4057qib7 4779 35 while while IN cord-005453-4057qib7 4779 36 the the DT cord-005453-4057qib7 4779 37 level level NN cord-005453-4057qib7 4779 38 of of IN cord-005453-4057qib7 4779 39 E2A e2a NN cord-005453-4057qib7 4779 40 - - HYPH cord-005453-4057qib7 4779 41 PBX1 PBX1 NNP cord-005453-4057qib7 4779 42 has have VBZ cord-005453-4057qib7 4779 43 obvious obvious JJ cord-005453-4057qib7 4779 44 effect effect NN cord-005453-4057qib7 4779 45 . . . cord-005453-4057qib7 4780 1 The the DT cord-005453-4057qib7 4780 2 out out NN cord-005453-4057qib7 4780 3 come come NN cord-005453-4057qib7 4780 4 of of IN cord-005453-4057qib7 4780 5 E2A e2a NN cord-005453-4057qib7 4780 6 - - HYPH cord-005453-4057qib7 4780 7 PBX1 PBX1 NNP cord-005453-4057qib7 4780 8 negative negative JJ cord-005453-4057qib7 4780 9 group group NN cord-005453-4057qib7 4780 10 was be VBD cord-005453-4057qib7 4780 11 obviously obviously RB cord-005453-4057qib7 4780 12 better well JJR cord-005453-4057qib7 4780 13 than than IN cord-005453-4057qib7 4780 14 positive positive JJ cord-005453-4057qib7 4780 15 group group NN cord-005453-4057qib7 4780 16 . . . cord-005453-4057qib7 4781 1 2 2 LS cord-005453-4057qib7 4781 2 . . . cord-005453-4057qib7 4782 1 CD19-CART cd19-cart NN cord-005453-4057qib7 4782 2 can can MD cord-005453-4057qib7 4782 3 obviously obviously RB cord-005453-4057qib7 4782 4 improve improve VB cord-005453-4057qib7 4782 5 the the DT cord-005453-4057qib7 4782 6 OS OS NNP cord-005453-4057qib7 4782 7 and and CC cord-005453-4057qib7 4782 8 LFS lfs NN cord-005453-4057qib7 4782 9 , , , cord-005453-4057qib7 4782 10 it -PRON- PRP cord-005453-4057qib7 4782 11 is be VBZ cord-005453-4057qib7 4782 12 mainly mainly RB cord-005453-4057qib7 4782 13 because because IN cord-005453-4057qib7 4782 14 of of IN cord-005453-4057qib7 4782 15 CD19-CART CD19-CART NNP cord-005453-4057qib7 4782 16 can can MD cord-005453-4057qib7 4782 17 makes make VBZ cord-005453-4057qib7 4782 18 more more JJR cord-005453-4057qib7 4782 19 patients patient NNS cord-005453-4057qib7 4782 20 fusion fusion NN cord-005453-4057qib7 4782 21 to to IN cord-005453-4057qib7 4782 22 zero zero CD cord-005453-4057qib7 4782 23 . . . cord-005453-4057qib7 4783 1 3 3 LS cord-005453-4057qib7 4783 2 . . . cord-005453-4057qib7 4784 1 For for IN cord-005453-4057qib7 4784 2 R r NN cord-005453-4057qib7 4784 3 / / SYM cord-005453-4057qib7 4784 4 R r NN cord-005453-4057qib7 4784 5 B b NN cord-005453-4057qib7 4784 6 - - , cord-005453-4057qib7 4784 7 ALL all RB cord-005453-4057qib7 4784 8 with with IN cord-005453-4057qib7 4784 9 E2A e2a FW cord-005453-4057qib7 4784 10 - - HYPH cord-005453-4057qib7 4784 11 PBX1 PBX1 NNP cord-005453-4057qib7 4784 12 in in IN cord-005453-4057qib7 4784 13 children child NNS cord-005453-4057qib7 4784 14 and and CC cord-005453-4057qib7 4784 15 adolescents adolescent NNS cord-005453-4057qib7 4784 16 , , , cord-005453-4057qib7 4784 17 if if IN cord-005453-4057qib7 4784 18 chemotherapy chemotherapy NN cord-005453-4057qib7 4784 19 ca can MD cord-005453-4057qib7 4784 20 n't not RB cord-005453-4057qib7 4784 21 make make VB cord-005453-4057qib7 4784 22 the the DT cord-005453-4057qib7 4784 23 fusion fusion NN cord-005453-4057qib7 4784 24 to to IN cord-005453-4057qib7 4784 25 zero zero CD cord-005453-4057qib7 4784 26 . . . cord-005453-4057qib7 4785 1 It -PRON- PRP cord-005453-4057qib7 4785 2 is be VBZ cord-005453-4057qib7 4785 3 suggested suggest VBN cord-005453-4057qib7 4785 4 to to TO cord-005453-4057qib7 4785 5 accept accept VB cord-005453-4057qib7 4785 6 CD19-CART CD19-CART NNP cord-005453-4057qib7 4785 7 therapy therapy NN cord-005453-4057qib7 4785 8 to to TO cord-005453-4057qib7 4785 9 make make VB cord-005453-4057qib7 4785 10 the the DT cord-005453-4057qib7 4785 11 fusion fusion NN cord-005453-4057qib7 4785 12 zero zero CD cord-005453-4057qib7 4785 13 . . . cord-005453-4057qib7 4786 1 It -PRON- PRP cord-005453-4057qib7 4786 2 can can MD cord-005453-4057qib7 4786 3 improve improve VB cord-005453-4057qib7 4786 4 the the DT cord-005453-4057qib7 4786 5 outcome outcome NN cord-005453-4057qib7 4786 6 of of IN cord-005453-4057qib7 4786 7 OS OS NNP cord-005453-4057qib7 4786 8 and and CC cord-005453-4057qib7 4786 9 LFS lfs NN cord-005453-4057qib7 4786 10 . . . cord-005453-4057qib7 4787 1 Disclosure disclosure NN cord-005453-4057qib7 4787 2 Background background NN cord-005453-4057qib7 4787 3 : : : cord-005453-4057qib7 4787 4 Currently currently RB cord-005453-4057qib7 4787 5 , , , cord-005453-4057qib7 4787 6 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 4787 7 stem stem NN cord-005453-4057qib7 4787 8 cell cell NN cord-005453-4057qib7 4787 9 transplantation transplantation NN cord-005453-4057qib7 4787 10 ( ( -LRB- cord-005453-4057qib7 4787 11 HSCT HSCT NNP cord-005453-4057qib7 4787 12 ) ) -RRB- cord-005453-4057qib7 4787 13 represents represent VBZ cord-005453-4057qib7 4787 14 the the DT cord-005453-4057qib7 4787 15 only only JJ cord-005453-4057qib7 4787 16 curative curative JJ cord-005453-4057qib7 4787 17 treatment treatment NN cord-005453-4057qib7 4787 18 for for IN cord-005453-4057qib7 4787 19 numerous numerous JJ cord-005453-4057qib7 4787 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 4787 21 malignancies malignancy NNS cord-005453-4057qib7 4787 22 like like IN cord-005453-4057qib7 4787 23 leukemias leukemia NNS cord-005453-4057qib7 4787 24 , , , cord-005453-4057qib7 4787 25 immune immune JJ cord-005453-4057qib7 4787 26 deficiencies deficiency NNS cord-005453-4057qib7 4787 27 or or CC cord-005453-4057qib7 4787 28 metabolic metabolic JJ cord-005453-4057qib7 4787 29 diseases disease NNS cord-005453-4057qib7 4787 30 . . . cord-005453-4057qib7 4788 1 CD34 CD34 NNP cord-005453-4057qib7 4788 2 serves serve VBZ cord-005453-4057qib7 4788 3 a a DT cord-005453-4057qib7 4788 4 quality quality NN cord-005453-4057qib7 4788 5 marker marker NN cord-005453-4057qib7 4788 6 for for IN cord-005453-4057qib7 4788 7 stem stem NN cord-005453-4057qib7 4788 8 cell cell NN cord-005453-4057qib7 4788 9 grafts graft NNS cord-005453-4057qib7 4788 10 , , , cord-005453-4057qib7 4788 11 which which WDT cord-005453-4057qib7 4788 12 is be VBZ cord-005453-4057qib7 4788 13 not not RB cord-005453-4057qib7 4788 14 solely solely RB cord-005453-4057qib7 4788 15 expressed express VBN cord-005453-4057qib7 4788 16 on on IN cord-005453-4057qib7 4788 17 stem stem NN cord-005453-4057qib7 4788 18 cells cell NNS cord-005453-4057qib7 4788 19 but but CC cord-005453-4057qib7 4788 20 also also RB cord-005453-4057qib7 4788 21 on on IN cord-005453-4057qib7 4788 22 a a DT cord-005453-4057qib7 4788 23 variety variety NN cord-005453-4057qib7 4788 24 of of IN cord-005453-4057qib7 4788 25 progenitors progenitor NNS cord-005453-4057qib7 4788 26 . . . cord-005453-4057qib7 4789 1 The the DT cord-005453-4057qib7 4789 2 role role NN cord-005453-4057qib7 4789 3 and and CC cord-005453-4057qib7 4789 4 the the DT cord-005453-4057qib7 4789 5 impact impact NN cord-005453-4057qib7 4789 6 of of IN cord-005453-4057qib7 4789 7 these these DT cord-005453-4057qib7 4789 8 subpopulations subpopulation NNS cord-005453-4057qib7 4789 9 remains remain VBZ cord-005453-4057qib7 4789 10 unknown unknown JJ cord-005453-4057qib7 4789 11 . . . cord-005453-4057qib7 4790 1 We -PRON- PRP cord-005453-4057qib7 4790 2 made make VBD cord-005453-4057qib7 4790 3 use use NN cord-005453-4057qib7 4790 4 of of IN cord-005453-4057qib7 4790 5 our -PRON- PRP$ cord-005453-4057qib7 4790 6 genetic genetic JJ cord-005453-4057qib7 4790 7 barcode barcode NN cord-005453-4057qib7 4790 8 system system NN cord-005453-4057qib7 4790 9 to to TO cord-005453-4057qib7 4790 10 analyze analyze VB cord-005453-4057qib7 4790 11 the the DT cord-005453-4057qib7 4790 12 influence influence NN cord-005453-4057qib7 4790 13 and and CC cord-005453-4057qib7 4790 14 contribution contribution NN cord-005453-4057qib7 4790 15 during during IN cord-005453-4057qib7 4790 16 reconstitution reconstitution NN cord-005453-4057qib7 4790 17 on on IN cord-005453-4057qib7 4790 18 a a DT cord-005453-4057qib7 4790 19 clonal clonal JJ cord-005453-4057qib7 4790 20 level level NN cord-005453-4057qib7 4790 21 . . . cord-005453-4057qib7 4791 1 Methods method NNS cord-005453-4057qib7 4791 2 : : : cord-005453-4057qib7 4792 1 Fluorescence fluorescence NN cord-005453-4057qib7 4792 2 activated activate VBD cord-005453-4057qib7 4792 3 cell cell NN cord-005453-4057qib7 4792 4 sorting sorting NN cord-005453-4057qib7 4792 5 ( ( -LRB- cord-005453-4057qib7 4792 6 FACS FACS NNP cord-005453-4057qib7 4792 7 ) ) -RRB- cord-005453-4057qib7 4792 8 was be VBD cord-005453-4057qib7 4792 9 used use VBN cord-005453-4057qib7 4792 10 to to TO cord-005453-4057qib7 4792 11 sort sort VB cord-005453-4057qib7 4792 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 4792 13 stem stem NN cord-005453-4057qib7 4792 14 and and CC cord-005453-4057qib7 4792 15 progenitor progenitor NN cord-005453-4057qib7 4792 16 populations population NNS cord-005453-4057qib7 4792 17 , , , cord-005453-4057qib7 4792 18 namely namely RB cord-005453-4057qib7 4792 19 HSCs hscs NN cord-005453-4057qib7 4792 20 , , , cord-005453-4057qib7 4792 21 MPPs mpp NNS cord-005453-4057qib7 4792 22 , , , cord-005453-4057qib7 4792 23 CMPs cmps NN cord-005453-4057qib7 4792 24 and and CC cord-005453-4057qib7 4792 25 CLPs clp NNS cord-005453-4057qib7 4792 26 , , , cord-005453-4057qib7 4792 27 which which WDT cord-005453-4057qib7 4792 28 were be VBD cord-005453-4057qib7 4792 29 lentivirally lentivirally RB cord-005453-4057qib7 4792 30 transduced transduce VBN cord-005453-4057qib7 4792 31 with with IN cord-005453-4057qib7 4792 32 our -PRON- PRP$ cord-005453-4057qib7 4792 33 previously previously RB cord-005453-4057qib7 4792 34 established establish VBN cord-005453-4057qib7 4792 35 BC32 BC32 NNP cord-005453-4057qib7 4792 36 barcoding barcoding NN cord-005453-4057qib7 4792 37 system system NN cord-005453-4057qib7 4792 38 . . . cord-005453-4057qib7 4793 1 After after IN cord-005453-4057qib7 4793 2 mixing mix VBG cord-005453-4057qib7 4793 3 the the DT cord-005453-4057qib7 4793 4 marked marked JJ cord-005453-4057qib7 4793 5 cells cell NNS cord-005453-4057qib7 4793 6 with with IN cord-005453-4057qib7 4793 7 bone bone NN cord-005453-4057qib7 4793 8 marrow marrow NN cord-005453-4057qib7 4793 9 support support NN cord-005453-4057qib7 4793 10 , , , cord-005453-4057qib7 4793 11 lethally lethally RB cord-005453-4057qib7 4793 12 irradiated irradiate VBN cord-005453-4057qib7 4793 13 recipient recipient NN cord-005453-4057qib7 4793 14 animals animal NNS cord-005453-4057qib7 4793 15 were be VBD cord-005453-4057qib7 4793 16 and and CC cord-005453-4057qib7 4793 17 transplanted transplant VBN cord-005453-4057qib7 4793 18 and and CC cord-005453-4057qib7 4793 19 monitored monitor VBD cord-005453-4057qib7 4793 20 over over IN cord-005453-4057qib7 4793 21 16 16 CD cord-005453-4057qib7 4793 22 weeks week NNS cord-005453-4057qib7 4793 23 . . . cord-005453-4057qib7 4794 1 We -PRON- PRP cord-005453-4057qib7 4794 2 focused focus VBD cord-005453-4057qib7 4794 3 on on IN cord-005453-4057qib7 4794 4 bone bone NN cord-005453-4057qib7 4794 5 marrow marrow NN cord-005453-4057qib7 4794 6 , , , cord-005453-4057qib7 4794 7 blood blood NN cord-005453-4057qib7 4794 8 , , , cord-005453-4057qib7 4794 9 spleen spleen NN cord-005453-4057qib7 4794 10 and and CC cord-005453-4057qib7 4794 11 thymus thymus NN cord-005453-4057qib7 4794 12 , , , cord-005453-4057qib7 4794 13 on on IN cord-005453-4057qib7 4794 14 chosen choose VBN cord-005453-4057qib7 4794 15 endpoints endpoint NNS cord-005453-4057qib7 4794 16 ( ( -LRB- cord-005453-4057qib7 4794 17 1w 1w NNP cord-005453-4057qib7 4794 18 , , , cord-005453-4057qib7 4794 19 3w 3w NNP cord-005453-4057qib7 4794 20 , , , cord-005453-4057qib7 4794 21 8w 8w NNP cord-005453-4057qib7 4794 22 , , , cord-005453-4057qib7 4794 23 16w 16w CD cord-005453-4057qib7 4794 24 ) ) -RRB- cord-005453-4057qib7 4794 25 and and CC cord-005453-4057qib7 4794 26 samples sample NNS cord-005453-4057qib7 4794 27 were be VBD cord-005453-4057qib7 4794 28 used use VBN cord-005453-4057qib7 4794 29 to to TO cord-005453-4057qib7 4794 30 analyze analyze VB cord-005453-4057qib7 4794 31 the the DT cord-005453-4057qib7 4794 32 contribution contribution NN cord-005453-4057qib7 4794 33 of of IN cord-005453-4057qib7 4794 34 the the DT cord-005453-4057qib7 4794 35 subpopulations subpopulation NNS cord-005453-4057qib7 4794 36 during during IN cord-005453-4057qib7 4794 37 the the DT cord-005453-4057qib7 4794 38 reconstitution reconstitution NN cord-005453-4057qib7 4794 39 process process NN cord-005453-4057qib7 4794 40 based base VBN cord-005453-4057qib7 4794 41 on on IN cord-005453-4057qib7 4794 42 fluorescent fluorescent JJ cord-005453-4057qib7 4794 43 protein protein NN cord-005453-4057qib7 4794 44 ( ( -LRB- cord-005453-4057qib7 4794 45 FP FP NNP cord-005453-4057qib7 4794 46 ) ) -RRB- cord-005453-4057qib7 4794 47 expression expression NN cord-005453-4057qib7 4794 48 . . . cord-005453-4057qib7 4795 1 To to TO cord-005453-4057qib7 4795 2 investigate investigate VB cord-005453-4057qib7 4795 3 the the DT cord-005453-4057qib7 4795 4 clonal clonal JJ cord-005453-4057qib7 4795 5 contribution contribution NN cord-005453-4057qib7 4795 6 in in IN cord-005453-4057qib7 4795 7 different different JJ cord-005453-4057qib7 4795 8 organs organ NNS cord-005453-4057qib7 4795 9 , , , cord-005453-4057qib7 4795 10 we -PRON- PRP cord-005453-4057qib7 4795 11 performed perform VBD cord-005453-4057qib7 4795 12 next next JJ cord-005453-4057qib7 4795 13 generation generation NN cord-005453-4057qib7 4795 14 sequencing sequencing NN cord-005453-4057qib7 4795 15 ( ( -LRB- cord-005453-4057qib7 4795 16 NGS NGS NNP cord-005453-4057qib7 4795 17 ) ) -RRB- cord-005453-4057qib7 4795 18 and and CC cord-005453-4057qib7 4795 19 frequencies frequency NNS cord-005453-4057qib7 4795 20 of of IN cord-005453-4057qib7 4795 21 unique unique JJ cord-005453-4057qib7 4795 22 barcodes barcode NNS cord-005453-4057qib7 4795 23 in in IN cord-005453-4057qib7 4795 24 a a DT cord-005453-4057qib7 4795 25 sample sample NN cord-005453-4057qib7 4795 26 were be VBD cord-005453-4057qib7 4795 27 analyzed analyze VBN cord-005453-4057qib7 4795 28 by by IN cord-005453-4057qib7 4795 29 bioinformatical bioinformatical JJ cord-005453-4057qib7 4795 30 approaches approach NNS cord-005453-4057qib7 4795 31 . . . cord-005453-4057qib7 4796 1 Results result NNS cord-005453-4057qib7 4796 2 : : : cord-005453-4057qib7 4797 1 A a DT cord-005453-4057qib7 4797 2 maximum maximum NN cord-005453-4057qib7 4797 3 of of IN cord-005453-4057qib7 4797 4 15 15 CD cord-005453-4057qib7 4797 5 % % NN cord-005453-4057qib7 4797 6 of of IN cord-005453-4057qib7 4797 7 cells cell NNS cord-005453-4057qib7 4797 8 expressed express VBD cord-005453-4057qib7 4797 9 the the DT cord-005453-4057qib7 4797 10 encoded encode VBN cord-005453-4057qib7 4797 11 FPs fp NNS cord-005453-4057qib7 4797 12 , , , cord-005453-4057qib7 4797 13 which which WDT cord-005453-4057qib7 4797 14 were be VBD cord-005453-4057qib7 4797 15 mostly mostly RB cord-005453-4057qib7 4797 16 derived derive VBN cord-005453-4057qib7 4797 17 from from IN cord-005453-4057qib7 4797 18 the the DT cord-005453-4057qib7 4797 19 HSCs hscs NN cord-005453-4057qib7 4797 20 and and CC cord-005453-4057qib7 4797 21 MPPs mpp NNS cord-005453-4057qib7 4797 22 . . . cord-005453-4057qib7 4798 1 CMP cmp NN cord-005453-4057qib7 4798 2 - - HYPH cord-005453-4057qib7 4798 3 derived derive VBN cord-005453-4057qib7 4798 4 cells cell NNS cord-005453-4057qib7 4798 5 were be VBD cord-005453-4057qib7 4798 6 only only RB cord-005453-4057qib7 4798 7 detected detect VBN cord-005453-4057qib7 4798 8 1 1 CD cord-005453-4057qib7 4798 9 week week NN cord-005453-4057qib7 4798 10 after after IN cord-005453-4057qib7 4798 11 transplantation transplantation NN cord-005453-4057qib7 4798 12 in in IN cord-005453-4057qib7 4798 13 the the DT cord-005453-4057qib7 4798 14 myeloid myeloid NN cord-005453-4057qib7 4798 15 compartment compartment NN cord-005453-4057qib7 4798 16 . . . cord-005453-4057qib7 4799 1 Cells cell NNS cord-005453-4057qib7 4799 2 derived derive VBN cord-005453-4057qib7 4799 3 from from IN cord-005453-4057qib7 4799 4 the the DT cord-005453-4057qib7 4799 5 CLPs clps NN cord-005453-4057qib7 4799 6 were be VBD cord-005453-4057qib7 4799 7 not not RB cord-005453-4057qib7 4799 8 detected detect VBN cord-005453-4057qib7 4799 9 at at IN cord-005453-4057qib7 4799 10 any any DT cord-005453-4057qib7 4799 11 time time NN cord-005453-4057qib7 4799 12 point point NN cord-005453-4057qib7 4799 13 . . . cord-005453-4057qib7 4800 1 We -PRON- PRP cord-005453-4057qib7 4800 2 analyzed analyze VBD cord-005453-4057qib7 4800 3 the the DT cord-005453-4057qib7 4800 4 barcode barcode NN cord-005453-4057qib7 4800 5 content content NN cord-005453-4057qib7 4800 6 of of IN cord-005453-4057qib7 4800 7 the the DT cord-005453-4057qib7 4800 8 differently differently RB cord-005453-4057qib7 4800 9 marked marked JJ cord-005453-4057qib7 4800 10 cells cell NNS cord-005453-4057qib7 4800 11 after after IN cord-005453-4057qib7 4800 12 next next JJ cord-005453-4057qib7 4800 13 - - HYPH cord-005453-4057qib7 4800 14 generation generation NN cord-005453-4057qib7 4800 15 - - HYPH cord-005453-4057qib7 4800 16 sequencing sequencing NN cord-005453-4057qib7 4800 17 . . . cord-005453-4057qib7 4801 1 In in IN cord-005453-4057qib7 4801 2 accordance accordance NN cord-005453-4057qib7 4801 3 with with IN cord-005453-4057qib7 4801 4 the the DT cord-005453-4057qib7 4801 5 FACS FACS NNP cord-005453-4057qib7 4801 6 data datum NNS cord-005453-4057qib7 4801 7 , , , cord-005453-4057qib7 4801 8 the the DT cord-005453-4057qib7 4801 9 majority majority NN cord-005453-4057qib7 4801 10 of of IN cord-005453-4057qib7 4801 11 the the DT cord-005453-4057qib7 4801 12 clones clone NNS cord-005453-4057qib7 4801 13 during during IN cord-005453-4057qib7 4801 14 the the DT cord-005453-4057qib7 4801 15 16 16 CD cord-005453-4057qib7 4801 16 weeks week NNS cord-005453-4057qib7 4801 17 of of IN cord-005453-4057qib7 4801 18 observation observation NN cord-005453-4057qib7 4801 19 are be VBP cord-005453-4057qib7 4801 20 derived derive VBN cord-005453-4057qib7 4801 21 from from IN cord-005453-4057qib7 4801 22 HSCs hscs NN cord-005453-4057qib7 4801 23 and and CC cord-005453-4057qib7 4801 24 MPPs mpp NNS cord-005453-4057qib7 4801 25 . . . cord-005453-4057qib7 4802 1 CMP cmp NN cord-005453-4057qib7 4802 2 - - HYPH cord-005453-4057qib7 4802 3 derived derive VBN cord-005453-4057qib7 4802 4 clones clone NNS cord-005453-4057qib7 4802 5 were be VBD cord-005453-4057qib7 4802 6 only only RB cord-005453-4057qib7 4802 7 contributing contribute VBG cord-005453-4057qib7 4802 8 during during IN cord-005453-4057qib7 4802 9 the the DT cord-005453-4057qib7 4802 10 first first JJ cord-005453-4057qib7 4802 11 weeks week NNS cord-005453-4057qib7 4802 12 and and CC cord-005453-4057qib7 4802 13 CLP clp NN cord-005453-4057qib7 4802 14 - - HYPH cord-005453-4057qib7 4802 15 derived derive VBN cord-005453-4057qib7 4802 16 clones clone NNS cord-005453-4057qib7 4802 17 are be VBP cord-005453-4057qib7 4802 18 barely barely RB cord-005453-4057qib7 4802 19 detectable detectable JJ cord-005453-4057qib7 4802 20 . . . cord-005453-4057qib7 4803 1 We -PRON- PRP cord-005453-4057qib7 4803 2 did do VBD cord-005453-4057qib7 4803 3 not not RB cord-005453-4057qib7 4803 4 observe observe VB cord-005453-4057qib7 4803 5 any any DT cord-005453-4057qib7 4803 6 major major JJ cord-005453-4057qib7 4803 7 differences difference NNS cord-005453-4057qib7 4803 8 with with IN cord-005453-4057qib7 4803 9 regard regard NN cord-005453-4057qib7 4803 10 to to IN cord-005453-4057qib7 4803 11 age age NN cord-005453-4057qib7 4803 12 of of IN cord-005453-4057qib7 4803 13 donor donor NN cord-005453-4057qib7 4803 14 or or CC cord-005453-4057qib7 4803 15 recipient recipient NN cord-005453-4057qib7 4803 16 , , , cord-005453-4057qib7 4803 17 despite despite IN cord-005453-4057qib7 4803 18 the the DT cord-005453-4057qib7 4803 19 total total JJ cord-005453-4057qib7 4803 20 number number NN cord-005453-4057qib7 4803 21 of of IN cord-005453-4057qib7 4803 22 clones clone NNS cord-005453-4057qib7 4803 23 is be VBZ cord-005453-4057qib7 4803 24 higher high JJR cord-005453-4057qib7 4803 25 in in IN cord-005453-4057qib7 4803 26 the the DT cord-005453-4057qib7 4803 27 group group NN cord-005453-4057qib7 4803 28 , , , cord-005453-4057qib7 4803 29 which which WDT cord-005453-4057qib7 4803 30 received receive VBD cord-005453-4057qib7 4803 31 the the DT cord-005453-4057qib7 4803 32 " " `` cord-005453-4057qib7 4803 33 aged aged JJ cord-005453-4057qib7 4803 34 " " '' cord-005453-4057qib7 4803 35 graft graft NN cord-005453-4057qib7 4803 36 , , , cord-005453-4057qib7 4803 37 independently independently RB cord-005453-4057qib7 4803 38 from from IN cord-005453-4057qib7 4803 39 the the DT cord-005453-4057qib7 4803 40 transduced transduce VBN cord-005453-4057qib7 4803 41 cell cell NN cord-005453-4057qib7 4803 42 population population NN cord-005453-4057qib7 4803 43 . . . cord-005453-4057qib7 4804 1 Conclusions conclusion NNS cord-005453-4057qib7 4804 2 : : : cord-005453-4057qib7 4805 1 Here here RB cord-005453-4057qib7 4805 2 we -PRON- PRP cord-005453-4057qib7 4805 3 show show VBP cord-005453-4057qib7 4805 4 the the DT cord-005453-4057qib7 4805 5 suitability suitability NN cord-005453-4057qib7 4805 6 of of IN cord-005453-4057qib7 4805 7 our -PRON- PRP$ cord-005453-4057qib7 4805 8 highly highly RB cord-005453-4057qib7 4805 9 complex complex JJ cord-005453-4057qib7 4805 10 multi multi JJ cord-005453-4057qib7 4805 11 - - JJ cord-005453-4057qib7 4805 12 color color JJ cord-005453-4057qib7 4805 13 barcode barcode NN cord-005453-4057qib7 4805 14 system system NN cord-005453-4057qib7 4805 15 to to TO cord-005453-4057qib7 4805 16 study study VB cord-005453-4057qib7 4805 17 the the DT cord-005453-4057qib7 4805 18 clonal clonal JJ cord-005453-4057qib7 4805 19 contribution contribution NN cord-005453-4057qib7 4805 20 of of IN cord-005453-4057qib7 4805 21 HSCs hscs NN cord-005453-4057qib7 4805 22 and and CC cord-005453-4057qib7 4805 23 three three CD cord-005453-4057qib7 4805 24 progenitor progenitor NN cord-005453-4057qib7 4805 25 populations population NNS cord-005453-4057qib7 4805 26 after after IN cord-005453-4057qib7 4805 27 HSCT HSCT NNP cord-005453-4057qib7 4805 28 . . . cord-005453-4057qib7 4806 1 Our -PRON- PRP$ cord-005453-4057qib7 4806 2 results result NNS cord-005453-4057qib7 4806 3 will will MD cord-005453-4057qib7 4806 4 contribute contribute VB cord-005453-4057qib7 4806 5 to to IN cord-005453-4057qib7 4806 6 a a DT cord-005453-4057qib7 4806 7 better well JJR cord-005453-4057qib7 4806 8 understanding understanding NN cord-005453-4057qib7 4806 9 how how WRB cord-005453-4057qib7 4806 10 these these DT cord-005453-4057qib7 4806 11 different different JJ cord-005453-4057qib7 4806 12 populations population NNS cord-005453-4057qib7 4806 13 interact interact VBP cord-005453-4057qib7 4806 14 to to TO cord-005453-4057qib7 4806 15 support support VB cord-005453-4057qib7 4806 16 the the DT cord-005453-4057qib7 4806 17 establishment establishment NN cord-005453-4057qib7 4806 18 of of IN cord-005453-4057qib7 4806 19 a a DT cord-005453-4057qib7 4806 20 new new JJ cord-005453-4057qib7 4806 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 4806 22 system system NN cord-005453-4057qib7 4806 23 . . . cord-005453-4057qib7 4807 1 Emphasized emphasize VBN cord-005453-4057qib7 4807 2 by by IN cord-005453-4057qib7 4807 3 the the DT cord-005453-4057qib7 4807 4 variability variability NN cord-005453-4057qib7 4807 5 in in IN cord-005453-4057qib7 4807 6 data datum NNS cord-005453-4057qib7 4807 7 of of IN cord-005453-4057qib7 4807 8 graft graft NN cord-005453-4057qib7 4807 9 and and CC cord-005453-4057qib7 4807 10 recipient recipient NN cord-005453-4057qib7 4807 11 age age NN cord-005453-4057qib7 4807 12 , , , cord-005453-4057qib7 4807 13 this this DT cord-005453-4057qib7 4807 14 comprehensive comprehensive JJ cord-005453-4057qib7 4807 15 analysis analysis NN cord-005453-4057qib7 4807 16 gives give VBZ cord-005453-4057qib7 4807 17 rise rise NN cord-005453-4057qib7 4807 18 to to IN cord-005453-4057qib7 4807 19 an an DT cord-005453-4057qib7 4807 20 impression impression NN cord-005453-4057qib7 4807 21 to to IN cord-005453-4057qib7 4807 22 the the DT cord-005453-4057qib7 4807 23 necessity necessity NN cord-005453-4057qib7 4807 24 of of IN cord-005453-4057qib7 4807 25 personalized personalized JJ cord-005453-4057qib7 4807 26 graft graft NN cord-005453-4057qib7 4807 27 composition composition NN cord-005453-4057qib7 4807 28 , , , cord-005453-4057qib7 4807 29 by by IN cord-005453-4057qib7 4807 30 which which WDT cord-005453-4057qib7 4807 31 treatment treatment NN cord-005453-4057qib7 4807 32 success success NN cord-005453-4057qib7 4807 33 could could MD cord-005453-4057qib7 4807 34 be be VB cord-005453-4057qib7 4807 35 influenced influence VBN cord-005453-4057qib7 4807 36 . . . cord-005453-4057qib7 4808 1 Disclosure disclosure NN cord-005453-4057qib7 4808 2 : : : cord-005453-4057qib7 4808 3 Nothing nothing NN cord-005453-4057qib7 4808 4 to to TO cord-005453-4057qib7 4808 5 declare declare VB cord-005453-4057qib7 4808 6 Survival survival NN cord-005453-4057qib7 4808 7 and and CC cord-005453-4057qib7 4808 8 fate fate NN cord-005453-4057qib7 4808 9 of of IN cord-005453-4057qib7 4808 10 adipose adipose JJ cord-005453-4057qib7 4808 11 derived derive VBN cord-005453-4057qib7 4808 12 mesenchymal mesenchymal JJ cord-005453-4057qib7 4808 13 stem stem NN cord-005453-4057qib7 4808 14 cells cell NNS cord-005453-4057qib7 4808 15 in in IN cord-005453-4057qib7 4808 16 a a DT cord-005453-4057qib7 4808 17 rat rat NN cord-005453-4057qib7 4808 18 brain brain NN cord-005453-4057qib7 4808 19 injury injury NN cord-005453-4057qib7 4808 20 model model NN cord-005453-4057qib7 4808 21 Background Background NNP cord-005453-4057qib7 4808 22 : : : cord-005453-4057qib7 4809 1 Mesenchymal Mesenchymal NNS cord-005453-4057qib7 4809 2 stem stem VBP cord-005453-4057qib7 4809 3 cells cell NNS cord-005453-4057qib7 4809 4 have have VBP cord-005453-4057qib7 4809 5 been be VBN cord-005453-4057qib7 4809 6 identified identify VBN cord-005453-4057qib7 4809 7 as as IN cord-005453-4057qib7 4809 8 promising promising JJ cord-005453-4057qib7 4809 9 candidates candidate NNS cord-005453-4057qib7 4809 10 in in IN cord-005453-4057qib7 4809 11 the the DT cord-005453-4057qib7 4809 12 treatment treatment NN cord-005453-4057qib7 4809 13 of of IN cord-005453-4057qib7 4809 14 Central central JJ cord-005453-4057qib7 4809 15 nervous nervous JJ cord-005453-4057qib7 4809 16 System system NN cord-005453-4057qib7 4809 17 ( ( -LRB- cord-005453-4057qib7 4809 18 CNS CNS NNP cord-005453-4057qib7 4809 19 ) ) -RRB- cord-005453-4057qib7 4809 20 injury injury NN cord-005453-4057qib7 4809 21 through through IN cord-005453-4057qib7 4809 22 neurotrophic neurotrophic JJ cord-005453-4057qib7 4809 23 support support NN cord-005453-4057qib7 4809 24 and and CC cord-005453-4057qib7 4809 25 immunomodulation immunomodulation NN cord-005453-4057qib7 4809 26 . . . cord-005453-4057qib7 4810 1 Adipose adipose JJ cord-005453-4057qib7 4810 2 tissue tissue NN cord-005453-4057qib7 4810 3 is be VBZ cord-005453-4057qib7 4810 4 an an DT cord-005453-4057qib7 4810 5 attractive attractive JJ cord-005453-4057qib7 4810 6 source source NN cord-005453-4057qib7 4810 7 of of IN cord-005453-4057qib7 4810 8 mesenchymal mesenchymal JJ cord-005453-4057qib7 4810 9 stromal stromal JJ cord-005453-4057qib7 4810 10 / / SYM cord-005453-4057qib7 4810 11 stem stem NN cord-005453-4057qib7 4810 12 cells cell NNS cord-005453-4057qib7 4810 13 ( ( -LRB- cord-005453-4057qib7 4810 14 ASCs ASCs NNP cord-005453-4057qib7 4810 15 ) ) -RRB- cord-005453-4057qib7 4810 16 for for IN cord-005453-4057qib7 4810 17 regenerative regenerative JJ cord-005453-4057qib7 4810 18 therapeutic therapeutic JJ cord-005453-4057qib7 4810 19 applications application NNS cord-005453-4057qib7 4810 20 because because IN cord-005453-4057qib7 4810 21 they -PRON- PRP cord-005453-4057qib7 4810 22 can can MD cord-005453-4057qib7 4810 23 be be VB cord-005453-4057qib7 4810 24 harvested harvest VBN cord-005453-4057qib7 4810 25 from from IN cord-005453-4057qib7 4810 26 autologous autologous JJ cord-005453-4057qib7 4810 27 donors donor NNS cord-005453-4057qib7 4810 28 with with IN cord-005453-4057qib7 4810 29 minimally minimally RB cord-005453-4057qib7 4810 30 invasive invasive JJ cord-005453-4057qib7 4810 31 methods method NNS cord-005453-4057qib7 4810 32 , , , cord-005453-4057qib7 4810 33 can can MD cord-005453-4057qib7 4810 34 be be VB cord-005453-4057qib7 4810 35 rapidly rapidly RB cord-005453-4057qib7 4810 36 expanded expand VBN cord-005453-4057qib7 4810 37 ex ex FW cord-005453-4057qib7 4810 38 vivo vivo FW cord-005453-4057qib7 4810 39 , , , cord-005453-4057qib7 4810 40 show show VBP cord-005453-4057qib7 4810 41 low low JJ cord-005453-4057qib7 4810 42 immunogenicity immunogenicity NN cord-005453-4057qib7 4810 43 if if IN cord-005453-4057qib7 4810 44 allogeneic allogeneic NN cord-005453-4057qib7 4810 45 , , , cord-005453-4057qib7 4810 46 and and CC cord-005453-4057qib7 4810 47 can can MD cord-005453-4057qib7 4810 48 be be VB cord-005453-4057qib7 4810 49 used use VBN cord-005453-4057qib7 4810 50 in in IN cord-005453-4057qib7 4810 51 autologous autologous JJ cord-005453-4057qib7 4810 52 or or CC cord-005453-4057qib7 4810 53 heterologous heterologous JJ cord-005453-4057qib7 4810 54 settings setting NNS cord-005453-4057qib7 4810 55 . . . cord-005453-4057qib7 4811 1 The the DT cord-005453-4057qib7 4811 2 present present JJ cord-005453-4057qib7 4811 3 study study NN cord-005453-4057qib7 4811 4 examines examine VBZ cord-005453-4057qib7 4811 5 the the DT cord-005453-4057qib7 4811 6 fate fate NN cord-005453-4057qib7 4811 7 and and CC cord-005453-4057qib7 4811 8 effects effect NNS cord-005453-4057qib7 4811 9 of of IN cord-005453-4057qib7 4811 10 intracerebroventricularly intracerebroventricularly FW cord-005453-4057qib7 4811 11 ( ( -LRB- cord-005453-4057qib7 4811 12 ICV ICV NNP cord-005453-4057qib7 4811 13 ) ) -RRB- cord-005453-4057qib7 4811 14 transplanted transplant VBD cord-005453-4057qib7 4811 15 ASCs ascs NN cord-005453-4057qib7 4811 16 in in IN cord-005453-4057qib7 4811 17 a a DT cord-005453-4057qib7 4811 18 traumatic traumatic JJ cord-005453-4057qib7 4811 19 brain brain NN cord-005453-4057qib7 4811 20 injury injury NN cord-005453-4057qib7 4811 21 ( ( -LRB- cord-005453-4057qib7 4811 22 TBI TBI NNP cord-005453-4057qib7 4811 23 ) ) -RRB- cord-005453-4057qib7 4811 24 model model NN cord-005453-4057qib7 4811 25 . . . cord-005453-4057qib7 4812 1 Methods method NNS cord-005453-4057qib7 4812 2 : : : cord-005453-4057qib7 4812 3 ASCs asc NNS cord-005453-4057qib7 4812 4 were be VBD cord-005453-4057qib7 4812 5 isolated isolate VBN cord-005453-4057qib7 4812 6 from from IN cord-005453-4057qib7 4812 7 inguinal inguinal JJ cord-005453-4057qib7 4812 8 fat fat JJ cord-005453-4057qib7 4812 9 pad pad NN cord-005453-4057qib7 4812 10 of of IN cord-005453-4057qib7 4812 11 adult adult NN cord-005453-4057qib7 4812 12 Wistar Wistar NNP cord-005453-4057qib7 4812 13 rats rat NNS cord-005453-4057qib7 4812 14 under under IN cord-005453-4057qib7 4812 15 sterile sterile JJ cord-005453-4057qib7 4812 16 conditions condition NNS cord-005453-4057qib7 4812 17 and and CC cord-005453-4057qib7 4812 18 cultured cultured JJ cord-005453-4057qib7 4812 19 according accord VBG cord-005453-4057qib7 4812 20 to to IN cord-005453-4057qib7 4812 21 standard standard JJ cord-005453-4057qib7 4812 22 procedures procedure NNS cord-005453-4057qib7 4812 23 . . . cord-005453-4057qib7 4813 1 ASCs ASCs NNP cord-005453-4057qib7 4813 2 at at IN cord-005453-4057qib7 4813 3 passage passage NN cord-005453-4057qib7 4813 4 2 2 CD cord-005453-4057qib7 4813 5 ( ( -LRB- cord-005453-4057qib7 4813 6 2x10 2x10 CD cord-005453-4057qib7 4813 7 5 5 CD cord-005453-4057qib7 4813 8 cells cell NNS cord-005453-4057qib7 4813 9 ) ) -RRB- cord-005453-4057qib7 4813 10 were be VBD cord-005453-4057qib7 4813 11 seeded seed VBN cord-005453-4057qib7 4813 12 and and CC cord-005453-4057qib7 4813 13 transfected transfecte VBN cord-005453-4057qib7 4813 14 with with IN cord-005453-4057qib7 4813 15 Sleeping sleep VBG cord-005453-4057qib7 4813 16 Beauty Beauty NNP cord-005453-4057qib7 4813 17 transposase transposase NN cord-005453-4057qib7 4813 18 and and CC cord-005453-4057qib7 4813 19 pT2 pT2 VBD cord-005453-4057qib7 4813 20 Venus Venus NNP cord-005453-4057qib7 4813 21 - - HYPH cord-005453-4057qib7 4813 22 neo neo NNP cord-005453-4057qib7 4813 23 R R NNP cord-005453-4057qib7 4813 24 plasmids plasmid NNS cord-005453-4057qib7 4813 25 . . . cord-005453-4057qib7 4814 1 Selection selection NN cord-005453-4057qib7 4814 2 with with IN cord-005453-4057qib7 4814 3 G418 G418 NNP cord-005453-4057qib7 4814 4 antibiotic antibiotic NN cord-005453-4057qib7 4814 5 resulted result VBD cord-005453-4057qib7 4814 6 in in IN cord-005453-4057qib7 4814 7 the the DT cord-005453-4057qib7 4814 8 generation generation NN cord-005453-4057qib7 4814 9 of of IN cord-005453-4057qib7 4814 10 a a DT cord-005453-4057qib7 4814 11 homogeneous homogeneous JJ cord-005453-4057qib7 4814 12 ASC ASC NNP cord-005453-4057qib7 4814 13 population population NN cord-005453-4057qib7 4814 14 which which WDT cord-005453-4057qib7 4814 15 expressed express VBD cord-005453-4057qib7 4814 16 fluorescent fluorescent JJ cord-005453-4057qib7 4814 17 Venus Venus NNP cord-005453-4057qib7 4814 18 protein protein NN cord-005453-4057qib7 4814 19 for for IN cord-005453-4057qib7 4814 20 several several JJ cord-005453-4057qib7 4814 21 passages passage NNS cord-005453-4057qib7 4814 22 , , , cord-005453-4057qib7 4814 23 Phenotypic phenotypic JJ cord-005453-4057qib7 4814 24 characterization characterization NN cord-005453-4057qib7 4814 25 showed show VBD cord-005453-4057qib7 4814 26 that that IN cord-005453-4057qib7 4814 27 these these DT cord-005453-4057qib7 4814 28 cells cell NNS cord-005453-4057qib7 4814 29 were be VBD cord-005453-4057qib7 4814 30 99.6 99.6 CD cord-005453-4057qib7 4814 31 % % NN cord-005453-4057qib7 4814 32 double double JJ cord-005453-4057qib7 4814 33 positive positive JJ cord-005453-4057qib7 4814 34 for for IN cord-005453-4057qib7 4814 35 CD44 CD44 NNP cord-005453-4057qib7 4814 36 and and CC cord-005453-4057qib7 4814 37 CD90 CD90 NNP cord-005453-4057qib7 4814 38 stem stem VBP cord-005453-4057qib7 4814 39 cell cell NN cord-005453-4057qib7 4814 40 markers marker NNS cord-005453-4057qib7 4814 41 , , , cord-005453-4057qib7 4814 42 verifying verify VBG cord-005453-4057qib7 4814 43 their -PRON- PRP$ cord-005453-4057qib7 4814 44 mesenchymal mesenchymal JJ cord-005453-4057qib7 4814 45 origin origin NN cord-005453-4057qib7 4814 46 . . . cord-005453-4057qib7 4815 1 TBI TBI NNP cord-005453-4057qib7 4815 2 was be VBD cord-005453-4057qib7 4815 3 induced induce VBN cord-005453-4057qib7 4815 4 by by IN cord-005453-4057qib7 4815 5 stereotactic stereotactic JJ cord-005453-4057qib7 4815 6 surgery surgery NN cord-005453-4057qib7 4815 7 under under IN cord-005453-4057qib7 4815 8 deep deep JJ cord-005453-4057qib7 4815 9 anaesthesia anaesthesia NN cord-005453-4057qib7 4815 10 and and CC cord-005453-4057qib7 4815 11 subsequently subsequently RB cord-005453-4057qib7 4815 12 ICV ICV NNP cord-005453-4057qib7 4815 13 transplantation transplantation NN cord-005453-4057qib7 4815 14 of of IN cord-005453-4057qib7 4815 15 Venus+ Venus+ NNP cord-005453-4057qib7 4815 16 ASCs ASCs NNP cord-005453-4057qib7 4815 17 was be VBD cord-005453-4057qib7 4815 18 performed perform VBN cord-005453-4057qib7 4815 19 on on IN cord-005453-4057qib7 4815 20 adult adult NN cord-005453-4057qib7 4815 21 Wistar Wistar NNP cord-005453-4057qib7 4815 22 rats rat NNS cord-005453-4057qib7 4815 23 . . . cord-005453-4057qib7 4816 1 Normal normal JJ cord-005453-4057qib7 4816 2 ASCs asc NNS cord-005453-4057qib7 4816 3 - - HYPH cord-005453-4057qib7 4816 4 transplanted transplant VBN cord-005453-4057qib7 4816 5 and and CC cord-005453-4057qib7 4816 6 TBI TBI NNP cord-005453-4057qib7 4816 7 - - HYPH cord-005453-4057qib7 4816 8 saline saline NN cord-005453-4057qib7 4816 9 transplanted transplant VBN cord-005453-4057qib7 4816 10 rats rat NNS cord-005453-4057qib7 4816 11 were be VBD cord-005453-4057qib7 4816 12 used use VBN cord-005453-4057qib7 4816 13 as as IN cord-005453-4057qib7 4816 14 controls control NNS cord-005453-4057qib7 4816 15 . . . cord-005453-4057qib7 4817 1 The the DT cord-005453-4057qib7 4817 2 proliferation proliferation NN cord-005453-4057qib7 4817 3 , , , cord-005453-4057qib7 4817 4 migration migration NN cord-005453-4057qib7 4817 5 , , , cord-005453-4057qib7 4817 6 survival survival NN cord-005453-4057qib7 4817 7 and and CC cord-005453-4057qib7 4817 8 fate fate NN cord-005453-4057qib7 4817 9 of of IN cord-005453-4057qib7 4817 10 transplanted transplanted JJ cord-005453-4057qib7 4817 11 ASCs asc NNS cord-005453-4057qib7 4817 12 and and CC cord-005453-4057qib7 4817 13 their -PRON- PRP$ cord-005453-4057qib7 4817 14 effect effect NN cord-005453-4057qib7 4817 15 on on IN cord-005453-4057qib7 4817 16 injury injury NN cord-005453-4057qib7 4817 17 restoration restoration NN cord-005453-4057qib7 4817 18 were be VBD cord-005453-4057qib7 4817 19 examined examine VBN cord-005453-4057qib7 4817 20 six six CD cord-005453-4057qib7 4817 21 weeks week NNS cord-005453-4057qib7 4817 22 post post NN cord-005453-4057qib7 4817 23 transplantation transplantation NN cord-005453-4057qib7 4817 24 ( ( -LRB- cord-005453-4057qib7 4817 25 PT PT NNP cord-005453-4057qib7 4817 26 ) ) -RRB- cord-005453-4057qib7 4817 27 . . . cord-005453-4057qib7 4818 1 Results result NNS cord-005453-4057qib7 4818 2 : : : cord-005453-4057qib7 4819 1 Six six CD cord-005453-4057qib7 4819 2 weeks week NNS cord-005453-4057qib7 4819 3 PT PT NNP cord-005453-4057qib7 4819 4 ASCs asc NNS cord-005453-4057qib7 4819 5 expressed express VBD cord-005453-4057qib7 4819 6 the the DT cord-005453-4057qib7 4819 7 fluorescence fluorescence NN cord-005453-4057qib7 4819 8 Venus Venus NNP cord-005453-4057qib7 4819 9 protein protein NN cord-005453-4057qib7 4819 10 and and CC cord-005453-4057qib7 4819 11 therefore therefore RB cord-005453-4057qib7 4819 12 were be VBD cord-005453-4057qib7 4819 13 identified identify VBN cord-005453-4057qib7 4819 14 in in IN cord-005453-4057qib7 4819 15 brain brain NN cord-005453-4057qib7 4819 16 parenchyma parenchyma NN cord-005453-4057qib7 4819 17 . . . cord-005453-4057qib7 4820 1 Their -PRON- PRP$ cord-005453-4057qib7 4820 2 presence presence NN cord-005453-4057qib7 4820 3 into into IN cord-005453-4057qib7 4820 4 brain brain NN cord-005453-4057qib7 4820 5 was be VBD cord-005453-4057qib7 4820 6 also also RB cord-005453-4057qib7 4820 7 confirmed confirm VBN cord-005453-4057qib7 4820 8 by by IN cord-005453-4057qib7 4820 9 Masson Masson NNP cord-005453-4057qib7 4820 10 trichrome trichrome JJ cord-005453-4057qib7 4820 11 staining staining NN cord-005453-4057qib7 4820 12 , , , cord-005453-4057qib7 4820 13 which which WDT cord-005453-4057qib7 4820 14 revealed reveal VBD cord-005453-4057qib7 4820 15 their -PRON- PRP$ cord-005453-4057qib7 4820 16 collagen collagen NN cord-005453-4057qib7 4820 17 depositions deposition NNS cord-005453-4057qib7 4820 18 . . . cord-005453-4057qib7 4821 1 ASCs asc NNS cord-005453-4057qib7 4821 2 were be VBD cord-005453-4057qib7 4821 3 found find VBN cord-005453-4057qib7 4821 4 in in IN cord-005453-4057qib7 4821 5 lesser less JJR cord-005453-4057qib7 4821 6 numbers number NNS cord-005453-4057qib7 4821 7 compared compare VBN cord-005453-4057qib7 4821 8 to to IN cord-005453-4057qib7 4821 9 those those DT cord-005453-4057qib7 4821 10 transplanted transplant VBN cord-005453-4057qib7 4821 11 and and CC cord-005453-4057qib7 4821 12 exhibited exhibit VBD cord-005453-4057qib7 4821 13 no no DT cord-005453-4057qib7 4821 14 proliferative proliferative JJ cord-005453-4057qib7 4821 15 activity activity NN cord-005453-4057qib7 4821 16 . . . cord-005453-4057qib7 4822 1 ASCs asc NNS cord-005453-4057qib7 4822 2 were be VBD cord-005453-4057qib7 4822 3 found find VBN cord-005453-4057qib7 4822 4 scattered scatter VBN cord-005453-4057qib7 4822 5 distributed distribute VBN cord-005453-4057qib7 4822 6 in in IN cord-005453-4057qib7 4822 7 brain brain NN cord-005453-4057qib7 4822 8 as as IN cord-005453-4057qib7 4822 9 individual individual JJ cord-005453-4057qib7 4822 10 cells cell NNS cord-005453-4057qib7 4822 11 , , , cord-005453-4057qib7 4822 12 and and CC cord-005453-4057qib7 4822 13 there there EX cord-005453-4057qib7 4822 14 were be VBD cord-005453-4057qib7 4822 15 no no DT cord-005453-4057qib7 4822 16 aggregates aggregate NNS cord-005453-4057qib7 4822 17 of of IN cord-005453-4057qib7 4822 18 ASCs asc NNS cord-005453-4057qib7 4822 19 or or CC cord-005453-4057qib7 4822 20 mass mass JJ cord-005453-4057qib7 4822 21 formation formation NN cord-005453-4057qib7 4822 22 into into IN cord-005453-4057qib7 4822 23 lateral lateral JJ cord-005453-4057qib7 4822 24 ventricles ventricle NNS cord-005453-4057qib7 4822 25 . . . cord-005453-4057qib7 4823 1 Extensive extensive JJ cord-005453-4057qib7 4823 2 migration migration NN cord-005453-4057qib7 4823 3 of of IN cord-005453-4057qib7 4823 4 ASCs ascs NN cord-005453-4057qib7 4823 5 was be VBD cord-005453-4057qib7 4823 6 mainly mainly RB cord-005453-4057qib7 4823 7 performed perform VBN cord-005453-4057qib7 4823 8 through through IN cord-005453-4057qib7 4823 9 white white JJ cord-005453-4057qib7 4823 10 matter matter NN cord-005453-4057qib7 4823 11 tracks track NNS cord-005453-4057qib7 4823 12 in in IN cord-005453-4057qib7 4823 13 the the DT cord-005453-4057qib7 4823 14 corpus corpus NNP cord-005453-4057qib7 4823 15 callosum callosum NNP cord-005453-4057qib7 4823 16 and and CC cord-005453-4057qib7 4823 17 fimbria fimbria NNP cord-005453-4057qib7 4823 18 of of IN cord-005453-4057qib7 4823 19 hippocampus hippocampus NNP cord-005453-4057qib7 4823 20 . . . cord-005453-4057qib7 4824 1 Six six CD cord-005453-4057qib7 4824 2 weeks week NNS cord-005453-4057qib7 4824 3 PT PT NNP cord-005453-4057qib7 4824 4 ASCs asc NNS cord-005453-4057qib7 4824 5 retained retain VBD cord-005453-4057qib7 4824 6 the the DT cord-005453-4057qib7 4824 7 characteristics characteristic NNS cord-005453-4057qib7 4824 8 of of IN cord-005453-4057qib7 4824 9 mesenchymal mesenchymal JJ cord-005453-4057qib7 4824 10 cells cell NNS cord-005453-4057qib7 4824 11 and and CC cord-005453-4057qib7 4824 12 did do VBD cord-005453-4057qib7 4824 13 not not RB cord-005453-4057qib7 4824 14 differentiate differentiate VB cord-005453-4057qib7 4824 15 into into IN cord-005453-4057qib7 4824 16 cells cell NNS cord-005453-4057qib7 4824 17 of of IN cord-005453-4057qib7 4824 18 neural neural JJ cord-005453-4057qib7 4824 19 lineage lineage NN cord-005453-4057qib7 4824 20 . . . cord-005453-4057qib7 4825 1 ASCs ASCs NNP cord-005453-4057qib7 4825 2 exhibited exhibit VBD cord-005453-4057qib7 4825 3 limited limited JJ cord-005453-4057qib7 4825 4 long long JJ cord-005453-4057qib7 4825 5 - - HYPH cord-005453-4057qib7 4825 6 term term NN cord-005453-4057qib7 4825 7 survival survival NN cord-005453-4057qib7 4825 8 , , , cord-005453-4057qib7 4825 9 which which WDT cord-005453-4057qib7 4825 10 is be VBZ cord-005453-4057qib7 4825 11 restricted restrict VBN cord-005453-4057qib7 4825 12 in in IN cord-005453-4057qib7 4825 13 perivascular perivascular JJ cord-005453-4057qib7 4825 14 areas area NNS cord-005453-4057qib7 4825 15 probably probably RB cord-005453-4057qib7 4825 16 contributing contribute VBG cord-005453-4057qib7 4825 17 to to IN cord-005453-4057qib7 4825 18 vascular vascular JJ cord-005453-4057qib7 4825 19 formation formation NN cord-005453-4057qib7 4825 20 . . . cord-005453-4057qib7 4826 1 Homing homing NN cord-005453-4057qib7 4826 2 of of IN cord-005453-4057qib7 4826 3 ASCs ascs NN cord-005453-4057qib7 4826 4 into into IN cord-005453-4057qib7 4826 5 peri peri NN cord-005453-4057qib7 4826 6 - - HYPH cord-005453-4057qib7 4826 7 injured injured JJ cord-005453-4057qib7 4826 8 area area NN cord-005453-4057qib7 4826 9 was be VBD cord-005453-4057qib7 4826 10 detected detect VBN cord-005453-4057qib7 4826 11 in in IN cord-005453-4057qib7 4826 12 half half NN cord-005453-4057qib7 4826 13 of of IN cord-005453-4057qib7 4826 14 the the DT cord-005453-4057qib7 4826 15 animals animal NNS cord-005453-4057qib7 4826 16 and and CC cord-005453-4057qib7 4826 17 achieved achieve VBN cord-005453-4057qib7 4826 18 through through IN cord-005453-4057qib7 4826 19 the the DT cord-005453-4057qib7 4826 20 corpus corpus NNP cord-005453-4057qib7 4826 21 callosum callosum NNP cord-005453-4057qib7 4826 22 , , , cord-005453-4057qib7 4826 23 as as IN cord-005453-4057qib7 4826 24 revealed reveal VBN cord-005453-4057qib7 4826 25 by by IN cord-005453-4057qib7 4826 26 the the DT cord-005453-4057qib7 4826 27 collagen collagen NN cord-005453-4057qib7 4826 28 depositions deposition NNS cord-005453-4057qib7 4826 29 , , , cord-005453-4057qib7 4826 30 in in IN cord-005453-4057qib7 4826 31 this this DT cord-005453-4057qib7 4826 32 white white JJ cord-005453-4057qib7 4826 33 matter matter NN cord-005453-4057qib7 4826 34 track track NN cord-005453-4057qib7 4826 35 . . . cord-005453-4057qib7 4827 1 Transplanted transplanted JJ cord-005453-4057qib7 4827 2 ASCs ASCs NNP cord-005453-4057qib7 4827 3 reduced reduce VBD cord-005453-4057qib7 4827 4 the the DT cord-005453-4057qib7 4827 5 area area NN cord-005453-4057qib7 4827 6 of of IN cord-005453-4057qib7 4827 7 TBI TBI NNP cord-005453-4057qib7 4827 8 cavity cavity NN cord-005453-4057qib7 4827 9 and and CC cord-005453-4057qib7 4827 10 did do VBD cord-005453-4057qib7 4827 11 not not RB cord-005453-4057qib7 4827 12 enhance enhance VB cord-005453-4057qib7 4827 13 the the DT cord-005453-4057qib7 4827 14 astroglial astroglial JJ cord-005453-4057qib7 4827 15 scarring scarring NN cord-005453-4057qib7 4827 16 in in IN cord-005453-4057qib7 4827 17 peri peri NN cord-005453-4057qib7 4827 18 - - HYPH cord-005453-4057qib7 4827 19 injured injured JJ cord-005453-4057qib7 4827 20 area area NN cord-005453-4057qib7 4827 21 . . . cord-005453-4057qib7 4828 1 In in IN cord-005453-4057qib7 4828 2 TBI TBI NNP cord-005453-4057qib7 4828 3 + + CC cord-005453-4057qib7 4828 4 ASCs asc NNS cord-005453-4057qib7 4828 5 transplanted transplant VBN cord-005453-4057qib7 4828 6 animals animal NNS cord-005453-4057qib7 4828 7 , , , cord-005453-4057qib7 4828 8 the the DT cord-005453-4057qib7 4828 9 cortical cortical JJ cord-005453-4057qib7 4828 10 injury injury NN cord-005453-4057qib7 4828 11 site site NN cord-005453-4057qib7 4828 12 , , , cord-005453-4057qib7 4828 13 showed show VBD cord-005453-4057qib7 4828 14 a a DT cord-005453-4057qib7 4828 15 significantly significantly RB cord-005453-4057qib7 4828 16 smaller small JJR cord-005453-4057qib7 4828 17 volume volume NN cord-005453-4057qib7 4828 18 and and CC cord-005453-4057qib7 4828 19 lower low JJR cord-005453-4057qib7 4828 20 % % NN cord-005453-4057qib7 4828 21 tissue tissue NN cord-005453-4057qib7 4828 22 loss loss NN cord-005453-4057qib7 4828 23 compared compare VBN cord-005453-4057qib7 4828 24 to to IN cord-005453-4057qib7 4828 25 that that DT cord-005453-4057qib7 4828 26 of of IN cord-005453-4057qib7 4828 27 TBI+vehicle TBI+vehicle NNP cord-005453-4057qib7 4828 28 animals animal NNS cord-005453-4057qib7 4828 29 ( ( -LRB- cord-005453-4057qib7 4828 30 1.90 1.90 CD cord-005453-4057qib7 4828 31 ±0.38 ±0.38 NN cord-005453-4057qib7 4828 32 mm mm NNP cord-005453-4057qib7 4828 33 3 3 CD cord-005453-4057qib7 4828 34 and and CC cord-005453-4057qib7 4828 35 12.25±2.83 12.25±2.83 CD cord-005453-4057qib7 4828 36 % % NN cord-005453-4057qib7 4828 37 respectively respectively RB cord-005453-4057qib7 4828 38 , , , cord-005453-4057qib7 4828 39 versus versus IN cord-005453-4057qib7 4828 40 1.12 1.12 CD cord-005453-4057qib7 4828 41 ±0.34 ±0.34 NN cord-005453-4057qib7 4828 42 mm mm NNP cord-005453-4057qib7 4828 43 3 3 CD cord-005453-4057qib7 4828 44 and and CC cord-005453-4057qib7 4828 45 6.57±1.67 6.57±1.67 CD cord-005453-4057qib7 4828 46 % % NN cord-005453-4057qib7 4828 47 , , , cord-005453-4057qib7 4828 48 P=0.015 P=0.015 NNP cord-005453-4057qib7 4828 49 and and CC cord-005453-4057qib7 4828 50 P=0.019 P=0.019 NNP cord-005453-4057qib7 4828 51 respectively respectively RB cord-005453-4057qib7 4828 52 ) ) -RRB- cord-005453-4057qib7 4828 53 . . . cord-005453-4057qib7 4829 1 Conclusions conclusion NNS cord-005453-4057qib7 4829 2 : : : cord-005453-4057qib7 4830 1 Considering consider VBG cord-005453-4057qib7 4830 2 the the DT cord-005453-4057qib7 4830 3 effects effect NNS cord-005453-4057qib7 4830 4 of of IN cord-005453-4057qib7 4830 5 ASCs asc NNS cord-005453-4057qib7 4830 6 on on IN cord-005453-4057qib7 4830 7 inflammation inflammation NN cord-005453-4057qib7 4830 8 and and CC cord-005453-4057qib7 4830 9 regeneration regeneration NN cord-005453-4057qib7 4830 10 , , , cord-005453-4057qib7 4830 11 we -PRON- PRP cord-005453-4057qib7 4830 12 suggest suggest VBP cord-005453-4057qib7 4830 13 that that IN cord-005453-4057qib7 4830 14 their -PRON- PRP$ cord-005453-4057qib7 4830 15 transplantation transplantation NN cord-005453-4057qib7 4830 16 after after IN cord-005453-4057qib7 4830 17 brain brain NN cord-005453-4057qib7 4830 18 injury injury NN cord-005453-4057qib7 4830 19 may may MD cord-005453-4057qib7 4830 20 promote promote VB cord-005453-4057qib7 4830 21 host host NN cord-005453-4057qib7 4830 22 brain brain NN cord-005453-4057qib7 4830 23 repair repair NN cord-005453-4057qib7 4830 24 mechanisms mechanism NNS cord-005453-4057qib7 4830 25 . . . cord-005453-4057qib7 4831 1 ASCs ascs JJ cord-005453-4057qib7 4831 2 transplantation transplantation NN cord-005453-4057qib7 4831 3 may may MD cord-005453-4057qib7 4831 4 be be VB cord-005453-4057qib7 4831 5 beneficial beneficial JJ cord-005453-4057qib7 4831 6 in in IN cord-005453-4057qib7 4831 7 TBI TBI NNP cord-005453-4057qib7 4831 8 , , , cord-005453-4057qib7 4831 9 however however RB cord-005453-4057qib7 4831 10 some some DT cord-005453-4057qib7 4831 11 of of IN cord-005453-4057qib7 4831 12 its -PRON- PRP$ cord-005453-4057qib7 4831 13 effects effect NNS cord-005453-4057qib7 4831 14 need need VBP cord-005453-4057qib7 4831 15 careful careful JJ cord-005453-4057qib7 4831 16 and and CC cord-005453-4057qib7 4831 17 indepth indepth JJ cord-005453-4057qib7 4831 18 evaluation evaluation NN cord-005453-4057qib7 4831 19 . . . cord-005453-4057qib7 4832 1 Disclosure disclosure NN cord-005453-4057qib7 4832 2 : : : cord-005453-4057qib7 4832 3 Nothing nothing NN cord-005453-4057qib7 4832 4 to to TO cord-005453-4057qib7 4832 5 declare declare VB cord-005453-4057qib7 4832 6 Xie Xie NNP cord-005453-4057qib7 4832 7 - - HYPH cord-005453-4057qib7 4832 8 Na Na NNP cord-005453-4057qib7 4832 9 Cao Cao NNP cord-005453-4057qib7 4832 10 1 1 CD cord-005453-4057qib7 4832 11 , , , cord-005453-4057qib7 4832 12 Yuan Yuan NNP cord-005453-4057qib7 4832 13 Kong Kong NNP cord-005453-4057qib7 4832 14 1 1 CD cord-005453-4057qib7 4832 15 , , , cord-005453-4057qib7 4832 16 Zhong Zhong NNP cord-005453-4057qib7 4832 17 - - HYPH cord-005453-4057qib7 4832 18 Shi Shi NNP cord-005453-4057qib7 4832 19 Lyu Lyu NNP cord-005453-4057qib7 4832 20 1,2 1,2 CD cord-005453-4057qib7 4832 21 , , , cord-005453-4057qib7 4832 22 Qi Qi NNP cord-005453-4057qib7 4832 23 Wen Wen NNP cord-005453-4057qib7 4832 24 1 1 CD cord-005453-4057qib7 4832 25 , , , cord-005453-4057qib7 4832 26 Min Min NNP cord-005453-4057qib7 4832 27 - - HYPH cord-005453-4057qib7 4832 28 Min Min NNP cord-005453-4057qib7 4832 29 Shi Shi NNP cord-005453-4057qib7 4832 30 1,2 1,2 CD cord-005453-4057qib7 4832 31 , , , cord-005453-4057qib7 4832 32 Qian Qian NNP cord-005453-4057qib7 4832 33 - - HYPH cord-005453-4057qib7 4832 34 Yu Yu NNP cord-005453-4057qib7 4832 35 Sun Sun NNP cord-005453-4057qib7 4832 36 1 1 CD cord-005453-4057qib7 4832 37 , , , cord-005453-4057qib7 4832 38 Yu Yu NNP cord-005453-4057qib7 4832 39 - - HYPH cord-005453-4057qib7 4832 40 Hong Hong NNP cord-005453-4057qib7 4832 41 Chen Chen NNP cord-005453-4057qib7 4832 42 1 1 CD cord-005453-4057qib7 4832 43 , , , cord-005453-4057qib7 4832 44 Yu Yu NNP cord-005453-4057qib7 4832 45 Wang Wang NNP cord-005453-4057qib7 4832 46 1 1 CD cord-005453-4057qib7 4832 47 , , , cord-005453-4057qib7 4832 48 Lan Lan NNP cord-005453-4057qib7 4832 49 - - HYPH cord-005453-4057qib7 4832 50 Ping Ping NNP cord-005453-4057qib7 4832 51 Xu Xu NNP cord-005453-4057qib7 4832 52 1 1 CD cord-005453-4057qib7 4833 1 , , , cord-005453-4057qib7 4833 2 Xiao Xiao NNP cord-005453-4057qib7 4833 3 - - HYPH cord-005453-4057qib7 4833 4 Hui Hui NNP cord-005453-4057qib7 4833 5 Zhang Zhang NNP cord-005453-4057qib7 4833 6 1 1 CD cord-005453-4057qib7 4833 7 , , , cord-005453-4057qib7 4833 8 Xiao Xiao NNP cord-005453-4057qib7 4833 9 - - HYPH cord-005453-4057qib7 4833 10 Jun Jun NNP cord-005453-4057qib7 4833 11 Huang Huang NNP cord-005453-4057qib7 4834 1 1,2 1,2 LS cord-005453-4057qib7 4835 1 Background background NN cord-005453-4057qib7 4835 2 : : : cord-005453-4057qib7 4836 1 Poor poor JJ cord-005453-4057qib7 4836 2 graft graft NN cord-005453-4057qib7 4836 3 function function NN cord-005453-4057qib7 4836 4 ( ( -LRB- cord-005453-4057qib7 4836 5 PGF PGF NNP cord-005453-4057qib7 4836 6 ) ) -RRB- cord-005453-4057qib7 4836 7 remains remain VBZ cord-005453-4057qib7 4836 8 a a DT cord-005453-4057qib7 4836 9 serious serious JJ cord-005453-4057qib7 4836 10 complication complication NN cord-005453-4057qib7 4836 11 after after IN cord-005453-4057qib7 4836 12 allogeneic allogeneic NN cord-005453-4057qib7 4836 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 4836 14 stem stem NN cord-005453-4057qib7 4836 15 cell cell NN cord-005453-4057qib7 4836 16 transplantation transplantation NN cord-005453-4057qib7 4836 17 ( ( -LRB- cord-005453-4057qib7 4836 18 allo allo NN cord-005453-4057qib7 4836 19 - - HYPH cord-005453-4057qib7 4836 20 HSCT HSCT NNP cord-005453-4057qib7 4836 21 ) ) -RRB- cord-005453-4057qib7 4836 22 . . . cord-005453-4057qib7 4837 1 Our -PRON- PRP$ cord-005453-4057qib7 4837 2 previous previous JJ cord-005453-4057qib7 4837 3 work work NN cord-005453-4057qib7 4837 4 reported report VBD cord-005453-4057qib7 4837 5 that that IN cord-005453-4057qib7 4837 6 abnormal abnormal JJ cord-005453-4057qib7 4837 7 bone bone NN cord-005453-4057qib7 4837 8 marrow marrow NN cord-005453-4057qib7 4837 9 ( ( -LRB- cord-005453-4057qib7 4837 10 BM BM NNP cord-005453-4057qib7 4837 11 ) ) -RRB- cord-005453-4057qib7 4837 12 endothelial endothelial JJ cord-005453-4057qib7 4837 13 cells cell NNS cord-005453-4057qib7 4837 14 ( ( -LRB- cord-005453-4057qib7 4837 15 ECs ec NNS cord-005453-4057qib7 4837 16 ) ) -RRB- cord-005453-4057qib7 4837 17 were be VBD cord-005453-4057qib7 4837 18 involved involve VBN cord-005453-4057qib7 4837 19 in in IN cord-005453-4057qib7 4837 20 the the DT cord-005453-4057qib7 4837 21 pathogenesis pathogenesis NN cord-005453-4057qib7 4837 22 of of IN cord-005453-4057qib7 4837 23 PGF PGF NNP cord-005453-4057qib7 4837 24 patients patient NNS cord-005453-4057qib7 4837 25 after after IN cord-005453-4057qib7 4837 26 allo allo NN cord-005453-4057qib7 4837 27 - - HYPH cord-005453-4057qib7 4837 28 HSCT HSCT NNP cord-005453-4057qib7 4837 29 ( ( -LRB- cord-005453-4057qib7 4837 30 BBMT2013 BBMT2013 NNP cord-005453-4057qib7 4837 31 ; ; : cord-005453-4057qib7 4837 32 BMT BMT NNP cord-005453-4057qib7 4837 33 2016 2016 CD cord-005453-4057qib7 4837 34 ; ; : cord-005453-4057qib7 4837 35 Blood2016 Blood2016 NNP cord-005453-4057qib7 4837 36 ) ) -RRB- cord-005453-4057qib7 4837 37 , , , cord-005453-4057qib7 4837 38 but but CC cord-005453-4057qib7 4837 39 the the DT cord-005453-4057qib7 4837 40 explicit explicit JJ cord-005453-4057qib7 4837 41 mechanism mechanism NN cord-005453-4057qib7 4837 42 requires require VBZ cord-005453-4057qib7 4837 43 further further JJ cord-005453-4057qib7 4837 44 clarification clarification NN cord-005453-4057qib7 4837 45 . . . cord-005453-4057qib7 4838 1 Autophagy Autophagy NNP cord-005453-4057qib7 4838 2 is be VBZ cord-005453-4057qib7 4838 3 a a DT cord-005453-4057qib7 4838 4 self self NN cord-005453-4057qib7 4838 5 - - HYPH cord-005453-4057qib7 4838 6 degradative degradative NN cord-005453-4057qib7 4838 7 process process NN cord-005453-4057qib7 4838 8 responsible responsible JJ cord-005453-4057qib7 4838 9 for for IN cord-005453-4057qib7 4838 10 the the DT cord-005453-4057qib7 4838 11 elimination elimination NN cord-005453-4057qib7 4838 12 of of IN cord-005453-4057qib7 4838 13 cytosolic cytosolic JJ cord-005453-4057qib7 4838 14 components component NNS cord-005453-4057qib7 4838 15 including include VBG cord-005453-4057qib7 4838 16 proteins protein NNS cord-005453-4057qib7 4838 17 and and CC cord-005453-4057qib7 4838 18 damaged damage VBN cord-005453-4057qib7 4838 19 organelles organelle NNS cord-005453-4057qib7 4838 20 . . . cord-005453-4057qib7 4839 1 Recent recent JJ cord-005453-4057qib7 4839 2 findings finding NNS cord-005453-4057qib7 4839 3 demonstrated demonstrate VBD cord-005453-4057qib7 4839 4 that that IN cord-005453-4057qib7 4839 5 stimulation stimulation NN cord-005453-4057qib7 4839 6 of of IN cord-005453-4057qib7 4839 7 autophagy autophagy NN cord-005453-4057qib7 4839 8 could could MD cord-005453-4057qib7 4839 9 reduce reduce VB cord-005453-4057qib7 4839 10 oxidative oxidative JJ cord-005453-4057qib7 4839 11 status status NN cord-005453-4057qib7 4839 12 and and CC cord-005453-4057qib7 4839 13 angiogenic angiogenic JJ cord-005453-4057qib7 4839 14 potential potential NN cord-005453-4057qib7 4839 15 in in IN cord-005453-4057qib7 4839 16 ECsafter ECsafter NNP cord-005453-4057qib7 4839 17 high high JJ cord-005453-4057qib7 4839 18 - - HYPH cord-005453-4057qib7 4839 19 glucose glucose NN cord-005453-4057qib7 4839 20 exposure exposure NN cord-005453-4057qib7 4839 21 , , , cord-005453-4057qib7 4839 22 from from IN cord-005453-4057qib7 4839 23 diabetic diabetic JJ cord-005453-4057qib7 4839 24 patients patient NNS cord-005453-4057qib7 4839 25 . . . cord-005453-4057qib7 4840 1 However however RB cord-005453-4057qib7 4840 2 , , , cord-005453-4057qib7 4840 3 little little JJ cord-005453-4057qib7 4840 4 is be VBZ cord-005453-4057qib7 4840 5 known know VBN cord-005453-4057qib7 4840 6 regarding regard VBG cord-005453-4057qib7 4840 7 the the DT cord-005453-4057qib7 4840 8 autophagy autophagy NN cord-005453-4057qib7 4840 9 of of IN cord-005453-4057qib7 4840 10 BM BM NNP cord-005453-4057qib7 4840 11 ECs ECs NNP cord-005453-4057qib7 4840 12 in in IN cord-005453-4057qib7 4840 13 PGF PGF NNP cord-005453-4057qib7 4840 14 patients patient NNS cord-005453-4057qib7 4840 15 . . . cord-005453-4057qib7 4841 1 Therefore therefore RB cord-005453-4057qib7 4841 2 , , , cord-005453-4057qib7 4841 3 the the DT cord-005453-4057qib7 4841 4 current current JJ cord-005453-4057qib7 4841 5 study study NN cord-005453-4057qib7 4841 6 was be VBD cord-005453-4057qib7 4841 7 performed perform VBN cord-005453-4057qib7 4841 8 to to TO cord-005453-4057qib7 4841 9 evaluate evaluate VB cord-005453-4057qib7 4841 10 whether whether IN cord-005453-4057qib7 4841 11 autophagy autophagy NN cord-005453-4057qib7 4841 12 in in IN cord-005453-4057qib7 4841 13 BM BM NNP cord-005453-4057qib7 4841 14 ECs ECs NNP cord-005453-4057qib7 4841 15 play play VBP cord-005453-4057qib7 4841 16 a a DT cord-005453-4057qib7 4841 17 role role NN cord-005453-4057qib7 4841 18 in in IN cord-005453-4057qib7 4841 19 the the DT cord-005453-4057qib7 4841 20 pathogenesis pathogenesis NN cord-005453-4057qib7 4841 21 of of IN cord-005453-4057qib7 4841 22 PGF PGF NNP cord-005453-4057qib7 4841 23 . . . cord-005453-4057qib7 4842 1 Moreover moreover RB cord-005453-4057qib7 4842 2 , , , cord-005453-4057qib7 4842 3 to to TO cord-005453-4057qib7 4842 4 investigate investigate VB cord-005453-4057qib7 4842 5 the the DT cord-005453-4057qib7 4842 6 effects effect NNS cord-005453-4057qib7 4842 7 of of IN cord-005453-4057qib7 4842 8 autophagic autophagic JJ cord-005453-4057qib7 4842 9 regulation regulation NN cord-005453-4057qib7 4842 10 on on IN cord-005453-4057qib7 4842 11 ECs ec NNS cord-005453-4057qib7 4842 12 and and CC cord-005453-4057qib7 4842 13 thereby thereby RB cord-005453-4057qib7 4842 14 regulating regulate VBG cord-005453-4057qib7 4842 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 4842 16 stem stem NN cord-005453-4057qib7 4842 17 cell cell NN cord-005453-4057qib7 4842 18 ( ( -LRB- cord-005453-4057qib7 4842 19 HSCs HSCs NNP cord-005453-4057qib7 4842 20 ) ) -RRB- cord-005453-4057qib7 4842 21 . . . cord-005453-4057qib7 4843 1 Methods method NNS cord-005453-4057qib7 4843 2 : : : cord-005453-4057qib7 4843 3 In in IN cord-005453-4057qib7 4843 4 the the DT cord-005453-4057qib7 4843 5 prospective prospective JJ cord-005453-4057qib7 4843 6 case case NN cord-005453-4057qib7 4843 7 - - HYPH cord-005453-4057qib7 4843 8 control control NN cord-005453-4057qib7 4843 9 study study NN cord-005453-4057qib7 4843 10 , , , cord-005453-4057qib7 4843 11 the the DT cord-005453-4057qib7 4843 12 autophagy autophagy NN cord-005453-4057qib7 4843 13 levels level NNS cord-005453-4057qib7 4843 14 were be VBD cord-005453-4057qib7 4843 15 compared compare VBN cord-005453-4057qib7 4843 16 in in IN cord-005453-4057qib7 4843 17 BM BM NNP cord-005453-4057qib7 4843 18 ECs ECs NNP cord-005453-4057qib7 4843 19 from from IN cord-005453-4057qib7 4843 20 PGF PGF NNP cord-005453-4057qib7 4843 21 patients patient NNS cord-005453-4057qib7 4843 22 , , , cord-005453-4057qib7 4843 23 and and CC cord-005453-4057qib7 4843 24 their -PRON- PRP$ cord-005453-4057qib7 4843 25 matched match VBN cord-005453-4057qib7 4843 26 good good JJ cord-005453-4057qib7 4843 27 graft graft NN cord-005453-4057qib7 4843 28 function function NN cord-005453-4057qib7 4843 29 ( ( -LRB- cord-005453-4057qib7 4843 30 GGF GGF NNP cord-005453-4057qib7 4843 31 ) ) -RRB- cord-005453-4057qib7 4843 32 patients patient NNS cord-005453-4057qib7 4843 33 . . . cord-005453-4057qib7 4844 1 The the DT cord-005453-4057qib7 4844 2 expression expression NN cord-005453-4057qib7 4844 3 levels level NNS cord-005453-4057qib7 4844 4 of of IN cord-005453-4057qib7 4844 5 autophagy autophagy NN cord-005453-4057qib7 4844 6 - - HYPH cord-005453-4057qib7 4844 7 related relate VBN cord-005453-4057qib7 4844 8 markers marker NNS cord-005453-4057qib7 4844 9 ( ( -LRB- cord-005453-4057qib7 4844 10 LC3 LC3 NNP cord-005453-4057qib7 4844 11 , , , cord-005453-4057qib7 4844 12 Beclin1 Beclin1 NNP cord-005453-4057qib7 4844 13 , , , cord-005453-4057qib7 4844 14 and and CC cord-005453-4057qib7 4844 15 P62 P62 NNP cord-005453-4057qib7 4844 16 ) ) -RRB- cord-005453-4057qib7 4844 17 , , , cord-005453-4057qib7 4844 18 and and CC cord-005453-4057qib7 4844 19 intracellular intracellular JJ cord-005453-4057qib7 4844 20 autophagosomes autophagosome NNS cord-005453-4057qib7 4844 21 were be VBD cord-005453-4057qib7 4844 22 detected detect VBN cord-005453-4057qib7 4844 23 by by IN cord-005453-4057qib7 4844 24 immunohistochemical immunohistochemical JJ cord-005453-4057qib7 4844 25 staining staining NN cord-005453-4057qib7 4844 26 , , , cord-005453-4057qib7 4844 27 flow flow NN cord-005453-4057qib7 4844 28 cytometry cytometry NN cord-005453-4057qib7 4844 29 , , , cord-005453-4057qib7 4844 30 western western JJ cord-005453-4057qib7 4844 31 blot blot NN cord-005453-4057qib7 4844 32 and and CC cord-005453-4057qib7 4844 33 transmission transmission NN cord-005453-4057qib7 4844 34 electron electron NN cord-005453-4057qib7 4844 35 microscopy microscopy NN cord-005453-4057qib7 4844 36 . . . cord-005453-4057qib7 4845 1 Subsequently subsequently RB cord-005453-4057qib7 4845 2 , , , cord-005453-4057qib7 4845 3 rapamycin rapamycin JJ cord-005453-4057qib7 4845 4 ( ( -LRB- cord-005453-4057qib7 4845 5 the the DT cord-005453-4057qib7 4845 6 autophagy autophagy NN cord-005453-4057qib7 4845 7 activators activator NNS cord-005453-4057qib7 4845 8 ) ) -RRB- cord-005453-4057qib7 4845 9 or or CC cord-005453-4057qib7 4845 10 hydroxychloroquine hydroxychloroquine NNP cord-005453-4057qib7 4845 11 ( ( -LRB- cord-005453-4057qib7 4845 12 HCQ HCQ NNP cord-005453-4057qib7 4845 13 , , , cord-005453-4057qib7 4845 14 the the DT cord-005453-4057qib7 4845 15 autophagy autophagy NN cord-005453-4057qib7 4845 16 inhibitor inhibitor NN cord-005453-4057qib7 4845 17 ) ) -RRB- cord-005453-4057qib7 4845 18 were be VBD cord-005453-4057qib7 4845 19 administrated administrate VBN cord-005453-4057qib7 4845 20 tothe tothe DT cord-005453-4057qib7 4845 21 7-day 7-day JJ cord-005453-4057qib7 4845 22 cultivated cultivate VBN cord-005453-4057qib7 4845 23 BM BM NNP cord-005453-4057qib7 4845 24 ECs ECs NNP cord-005453-4057qib7 4845 25 and and CC cord-005453-4057qib7 4845 26 Human Human NNP cord-005453-4057qib7 4845 27 Umbilical Umbilical NNP cord-005453-4057qib7 4845 28 Vein Vein NNP cord-005453-4057qib7 4845 29 Endothelial Endothelial NNP cord-005453-4057qib7 4845 30 Cells cell NNS cord-005453-4057qib7 4845 31 ( ( -LRB- cord-005453-4057qib7 4845 32 HUVECs huvec NNS cord-005453-4057qib7 4845 33 ) ) -RRB- cord-005453-4057qib7 4845 34 , , , cord-005453-4057qib7 4845 35 respectively respectively RB cord-005453-4057qib7 4845 36 . . . cord-005453-4057qib7 4846 1 The the DT cord-005453-4057qib7 4846 2 autophagic autophagic NN cord-005453-4057qib7 4846 3 vacuoleswere vacuoleswere RB cord-005453-4057qib7 4846 4 detected detect VBN cord-005453-4057qib7 4846 5 by by IN cord-005453-4057qib7 4846 6 Monodansylcadaverine Monodansylcadaverine NNP cord-005453-4057qib7 4846 7 ( ( -LRB- cord-005453-4057qib7 4846 8 MDC MDC NNP cord-005453-4057qib7 4846 9 ) ) -RRB- cord-005453-4057qib7 4846 10 staining stain VBG cord-005453-4057qib7 4846 11 assay assay NN cord-005453-4057qib7 4846 12 . . . cord-005453-4057qib7 4847 1 The the DT cord-005453-4057qib7 4847 2 BM BM NNP cord-005453-4057qib7 4847 3 ECsand ECsand NNP cord-005453-4057qib7 4847 4 HUVECs huvec NNS cord-005453-4057qib7 4847 5 were be VBD cord-005453-4057qib7 4847 6 evaluated evaluate VBN cord-005453-4057qib7 4847 7 by by IN cord-005453-4057qib7 4847 8 cell cell NN cord-005453-4057qib7 4847 9 counting counting NN cord-005453-4057qib7 4847 10 , , , cord-005453-4057qib7 4847 11 DiI dii NN cord-005453-4057qib7 4847 12 - - HYPH cord-005453-4057qib7 4847 13 Ac Ac NNP cord-005453-4057qib7 4847 14 - - HYPH cord-005453-4057qib7 4847 15 LDL LDL NNP cord-005453-4057qib7 4847 16 and and CC cord-005453-4057qib7 4847 17 FITC FITC NNP cord-005453-4057qib7 4847 18 - - HYPH cord-005453-4057qib7 4847 19 lectin lectin NN cord-005453-4057qib7 4847 20 - - : cord-005453-4057qib7 4847 21 UEA-1 UEA-1 NNP cord-005453-4057qib7 4847 22 double double JJ cord-005453-4057qib7 4847 23 staining staining NN cord-005453-4057qib7 4847 24 , , , cord-005453-4057qib7 4847 25 migration migration NN cord-005453-4057qib7 4847 26 , , , cord-005453-4057qib7 4847 27 cell cell NN cord-005453-4057qib7 4847 28 proliferation proliferation NN cord-005453-4057qib7 4847 29 , , , cord-005453-4057qib7 4847 30 and and CC cord-005453-4057qib7 4847 31 levels level NNS cord-005453-4057qib7 4847 32 of of IN cord-005453-4057qib7 4847 33 reactive reactive JJ cord-005453-4057qib7 4847 34 oxygen oxygen NN cord-005453-4057qib7 4847 35 species specie NNS cord-005453-4057qib7 4847 36 ( ( -LRB- cord-005453-4057qib7 4847 37 ROS ROS NNP cord-005453-4057qib7 4847 38 ) ) -RRB- cord-005453-4057qib7 4847 39 . . . cord-005453-4057qib7 4848 1 To to TO cord-005453-4057qib7 4848 2 explore explore VB cord-005453-4057qib7 4848 3 whether whether IN cord-005453-4057qib7 4848 4 autophagy autophagy NN cord-005453-4057qib7 4848 5 would would MD cord-005453-4057qib7 4848 6 affect affect VB cord-005453-4057qib7 4848 7 the the DT cord-005453-4057qib7 4848 8 ability ability NN cord-005453-4057qib7 4848 9 of of IN cord-005453-4057qib7 4848 10 BM BM NNP cord-005453-4057qib7 4848 11 ECs ECs NNP cord-005453-4057qib7 4848 12 to to TO cord-005453-4057qib7 4848 13 support support VB cord-005453-4057qib7 4848 14 HSCs hscs NN cord-005453-4057qib7 4848 15 in in IN cord-005453-4057qib7 4848 16 vitro vitro FW cord-005453-4057qib7 4848 17 , , , cord-005453-4057qib7 4848 18 BM BM NNP cord-005453-4057qib7 4848 19 CD34 CD34 NNP cord-005453-4057qib7 4848 20 + + CC cord-005453-4057qib7 4848 21 cells cell NNS cord-005453-4057qib7 4848 22 from from IN cord-005453-4057qib7 4848 23 healthy healthy JJ cord-005453-4057qib7 4848 24 donors donor NNS cord-005453-4057qib7 4848 25 were be VBD cord-005453-4057qib7 4848 26 co co JJ cord-005453-4057qib7 4848 27 - - JJ cord-005453-4057qib7 4848 28 cultured cultured JJ cord-005453-4057qib7 4848 29 with with IN cord-005453-4057qib7 4848 30 cultivated cultivate VBN cord-005453-4057qib7 4848 31 BM BM NNP cord-005453-4057qib7 4848 32 ECs ECs NNP cord-005453-4057qib7 4848 33 and and CC cord-005453-4057qib7 4848 34 HUVECs huvec NNS cord-005453-4057qib7 4848 35 . . . cord-005453-4057qib7 4849 1 Colony colony NN cord-005453-4057qib7 4849 2 - - HYPH cord-005453-4057qib7 4849 3 forming form VBG cord-005453-4057qib7 4849 4 unit unit NN cord-005453-4057qib7 4849 5 ( ( -LRB- cord-005453-4057qib7 4849 6 CFU CFU NNP cord-005453-4057qib7 4849 7 ) ) -RRB- cord-005453-4057qib7 4849 8 and and CC cord-005453-4057qib7 4849 9 the the DT cord-005453-4057qib7 4849 10 apoptosis apoptosis NN cord-005453-4057qib7 4849 11 of of IN cord-005453-4057qib7 4849 12 co co JJ cord-005453-4057qib7 4849 13 - - JJ cord-005453-4057qib7 4849 14 cultured cultured JJ cord-005453-4057qib7 4849 15 HSCs hsc NNS cord-005453-4057qib7 4849 16 were be VBD cord-005453-4057qib7 4849 17 analyzed analyze VBN cord-005453-4057qib7 4849 18 . . . cord-005453-4057qib7 4850 1 Results result NNS cord-005453-4057qib7 4850 2 : : : cord-005453-4057qib7 4851 1 The the DT cord-005453-4057qib7 4851 2 defective defective JJ cord-005453-4057qib7 4851 3 autophagy autophagy NN cord-005453-4057qib7 4851 4 in in IN cord-005453-4057qib7 4851 5 BM BM NNP cord-005453-4057qib7 4851 6 ECs ECs NNP cord-005453-4057qib7 4851 7 , , , cord-005453-4057qib7 4851 8 characterized characterize VBN cord-005453-4057qib7 4851 9 by by IN cord-005453-4057qib7 4851 10 decreased decrease VBN cord-005453-4057qib7 4851 11 intracellular intracellular JJ cord-005453-4057qib7 4851 12 autophagosomes autophagosome NNS cord-005453-4057qib7 4851 13 and and CC cord-005453-4057qib7 4851 14 autophagic autophagic JJ cord-005453-4057qib7 4851 15 vacuoles vacuole NNS cord-005453-4057qib7 4851 16 , , , cord-005453-4057qib7 4851 17 decreased decrease VBD cord-005453-4057qib7 4851 18 expression expression NN cord-005453-4057qib7 4851 19 of of IN cord-005453-4057qib7 4851 20 LC3-II lc3-ii NN cord-005453-4057qib7 4851 21 and and CC cord-005453-4057qib7 4851 22 Beclin1 Beclin1 NNP cord-005453-4057qib7 4851 23 , , , cord-005453-4057qib7 4851 24 and and CC cord-005453-4057qib7 4851 25 high high JJ cord-005453-4057qib7 4851 26 level level NN cord-005453-4057qib7 4851 27 of of IN cord-005453-4057qib7 4851 28 P62 P62 NNP cord-005453-4057qib7 4851 29 , , , cord-005453-4057qib7 4851 30 were be VBD cord-005453-4057qib7 4851 31 observed observe VBN cord-005453-4057qib7 4851 32 in in IN cord-005453-4057qib7 4851 33 PGF PGF NNP cord-005453-4057qib7 4851 34 patients patient NNS cord-005453-4057qib7 4851 35 compared compare VBN cord-005453-4057qib7 4851 36 with with IN cord-005453-4057qib7 4851 37 GGF GGF NNP cord-005453-4057qib7 4851 38 patients patient NNS cord-005453-4057qib7 4851 39 . . . cord-005453-4057qib7 4852 1 Moreover moreover RB cord-005453-4057qib7 4852 2 , , , cord-005453-4057qib7 4852 3 the the DT cord-005453-4057qib7 4852 4 coculture coculture NN cord-005453-4057qib7 4852 5 of of IN cord-005453-4057qib7 4852 6 BM BM NNP cord-005453-4057qib7 4852 7 CD34 CD34 NNP cord-005453-4057qib7 4852 8 + + CC cord-005453-4057qib7 4852 9 cells cell NNS cord-005453-4057qib7 4852 10 with with IN cord-005453-4057qib7 4852 11 BM BM NNP cord-005453-4057qib7 4852 12 ECs ECs NNP cord-005453-4057qib7 4852 13 showed show VBD cord-005453-4057qib7 4852 14 significant significant JJ cord-005453-4057qib7 4852 15 deficient deficient JJ cord-005453-4057qib7 4852 16 CFU cfu NN cord-005453-4057qib7 4852 17 plating plating NN cord-005453-4057qib7 4852 18 efficiency efficiency NN cord-005453-4057qib7 4852 19 , , , cord-005453-4057qib7 4852 20 and and CC cord-005453-4057qib7 4852 21 increased increase VBN cord-005453-4057qib7 4852 22 apoptosis apoptosis NN cord-005453-4057qib7 4852 23 of of IN cord-005453-4057qib7 4852 24 CD34 CD34 NNP cord-005453-4057qib7 4852 25 + + CC cord-005453-4057qib7 4852 26 cells cell NNS cord-005453-4057qib7 4852 27 in in IN cord-005453-4057qib7 4852 28 PGF PGF NNP cord-005453-4057qib7 4852 29 patients patient NNS cord-005453-4057qib7 4852 30 . . . cord-005453-4057qib7 4853 1 In in IN cord-005453-4057qib7 4853 2 vitro vitro FW cord-005453-4057qib7 4853 3 upregulation upregulation NN cord-005453-4057qib7 4853 4 of of IN cord-005453-4057qib7 4853 5 autophagy autophagy NN cord-005453-4057qib7 4853 6 by by IN cord-005453-4057qib7 4853 7 rapamycin rapamycin NNS cord-005453-4057qib7 4853 8 quantitatively quantitatively RB cord-005453-4057qib7 4853 9 and and CC cord-005453-4057qib7 4853 10 functionally functionally RB cord-005453-4057qib7 4853 11 improved improve VBN cord-005453-4057qib7 4853 12 BM BM NNP cord-005453-4057qib7 4853 13 ECsand ECsand NNP cord-005453-4057qib7 4853 14 HUVECs huvec NNS cord-005453-4057qib7 4853 15 , , , cord-005453-4057qib7 4853 16 which which WDT cord-005453-4057qib7 4853 17 manifested manifest VBD cord-005453-4057qib7 4853 18 as as IN cord-005453-4057qib7 4853 19 more more JJR cord-005453-4057qib7 4853 20 DiI dii NN cord-005453-4057qib7 4853 21 - - HYPH cord-005453-4057qib7 4853 22 Ac ac NN cord-005453-4057qib7 4853 23 - - HYPH cord-005453-4057qib7 4853 24 LDL LDL NNP cord-005453-4057qib7 4853 25 and and CC cord-005453-4057qib7 4853 26 FITC FITC NNP cord-005453-4057qib7 4853 27 - - HYPH cord-005453-4057qib7 4853 28 lectin lectin NN cord-005453-4057qib7 4853 29 - - : cord-005453-4057qib7 4853 30 UEA-1 UEA-1 NNP cord-005453-4057qib7 4853 31 double double JJ cord-005453-4057qib7 4853 32 stained stained JJ cord-005453-4057qib7 4853 33 cells cell NNS cord-005453-4057qib7 4853 34 , , , cord-005453-4057qib7 4853 35 increased increase VBN cord-005453-4057qib7 4853 36 capacities capacity NNS cord-005453-4057qib7 4853 37 of of IN cord-005453-4057qib7 4853 38 migration migration NN cord-005453-4057qib7 4853 39 , , , cord-005453-4057qib7 4853 40 lower low JJR cord-005453-4057qib7 4853 41 levels level NNS cord-005453-4057qib7 4853 42 of of IN cord-005453-4057qib7 4853 43 ROS ROS NNP cord-005453-4057qib7 4853 44 and and CC cord-005453-4057qib7 4853 45 apoptosis apoptosis NN cord-005453-4057qib7 4853 46 via via IN cord-005453-4057qib7 4853 47 regulating regulate VBG cord-005453-4057qib7 4853 48 Beclin1 Beclin1 NNP cord-005453-4057qib7 4853 49 pathway pathway NN cord-005453-4057qib7 4853 50 , , , cord-005453-4057qib7 4853 51 whereas whereas IN cord-005453-4057qib7 4853 52 inhibition inhibition NN cord-005453-4057qib7 4853 53 of of IN cord-005453-4057qib7 4853 54 autophagy autophagy NN cord-005453-4057qib7 4853 55 by by IN cord-005453-4057qib7 4853 56 HCQ HCQ NNP cord-005453-4057qib7 4853 57 aggravated aggravate VBD cord-005453-4057qib7 4853 58 the the DT cord-005453-4057qib7 4853 59 HUVECs huvec NNS cord-005453-4057qib7 4853 60 and and CC cord-005453-4057qib7 4853 61 BM BM NNP cord-005453-4057qib7 4853 62 ECs ECs NNP cord-005453-4057qib7 4853 63 from from IN cord-005453-4057qib7 4853 64 PGF PGF NNP cord-005453-4057qib7 4853 65 patients patient NNS cord-005453-4057qib7 4853 66 . . . cord-005453-4057qib7 4854 1 Furthermore furthermore RB cord-005453-4057qib7 4854 2 , , , cord-005453-4057qib7 4854 3 in in IN cord-005453-4057qib7 4854 4 vitro vitro FW cord-005453-4057qib7 4854 5 upregulation upregulation NN cord-005453-4057qib7 4854 6 of of IN cord-005453-4057qib7 4854 7 autophagy autophagy NN cord-005453-4057qib7 4854 8 by by IN cord-005453-4057qib7 4854 9 rapamycin rapamycin NN cord-005453-4057qib7 4854 10 significant significant JJ cord-005453-4057qib7 4854 11 improved improve VBD cord-005453-4057qib7 4854 12 CFU CFU NNP cord-005453-4057qib7 4854 13 plating plating NN cord-005453-4057qib7 4854 14 efficiency efficiency NN cord-005453-4057qib7 4854 15 , , , cord-005453-4057qib7 4854 16 and and CC cord-005453-4057qib7 4854 17 decreased decrease VBD cord-005453-4057qib7 4854 18 apoptosis apoptosis NN cord-005453-4057qib7 4854 19 in in IN cord-005453-4057qib7 4854 20 BM BM NNP cord-005453-4057qib7 4854 21 HSCs HSCs NNP cord-005453-4057qib7 4854 22 co co NN cord-005453-4057qib7 4854 23 - - JJ cord-005453-4057qib7 4854 24 cultured cultured JJ cord-005453-4057qib7 4854 25 with with IN cord-005453-4057qib7 4854 26 HUVECs huvec NNS cord-005453-4057qib7 4854 27 and and CC cord-005453-4057qib7 4854 28 BM BM NNP cord-005453-4057qib7 4854 29 ECs ECs NNP cord-005453-4057qib7 4854 30 from from IN cord-005453-4057qib7 4854 31 PGF PGF NNP cord-005453-4057qib7 4854 32 patients patient NNS cord-005453-4057qib7 4854 33 . . . cord-005453-4057qib7 4855 1 Conclusions conclusion NNS cord-005453-4057qib7 4855 2 : : : cord-005453-4057qib7 4856 1 These these DT cord-005453-4057qib7 4856 2 findings finding NNS cord-005453-4057qib7 4856 3 suggest suggest VBP cord-005453-4057qib7 4856 4 that that IN cord-005453-4057qib7 4856 5 defective defective JJ cord-005453-4057qib7 4856 6 autophagy autophagy NN cord-005453-4057qib7 4856 7 in in IN cord-005453-4057qib7 4856 8 BM BM NNP cord-005453-4057qib7 4856 9 ECs ECs NNP cord-005453-4057qib7 4856 10 may may MD cord-005453-4057qib7 4856 11 be be VB cord-005453-4057qib7 4856 12 involved involve VBN cord-005453-4057qib7 4856 13 in in IN cord-005453-4057qib7 4856 14 the the DT cord-005453-4057qib7 4856 15 pathogenesis pathogenesis NN cord-005453-4057qib7 4856 16 of of IN cord-005453-4057qib7 4856 17 PGF PGF NNP cord-005453-4057qib7 4856 18 . . . cord-005453-4057qib7 4857 1 The the DT cord-005453-4057qib7 4857 2 effect effect NN cord-005453-4057qib7 4857 3 of of IN cord-005453-4057qib7 4857 4 rapamycin rapamycin NNS cord-005453-4057qib7 4857 5 in in IN cord-005453-4057qib7 4857 6 PGFpatients pgfpatient NNS cord-005453-4057qib7 4857 7 is be VBZ cord-005453-4057qib7 4857 8 potentially potentially RB cord-005453-4057qib7 4857 9 mediated mediate VBN cord-005453-4057qib7 4857 10 by by IN cord-005453-4057qib7 4857 11 improving improve VBG cord-005453-4057qib7 4857 12 the the DT cord-005453-4057qib7 4857 13 dysfunctional dysfunctional JJ cord-005453-4057qib7 4857 14 BM BM NNP cord-005453-4057qib7 4857 15 ECsto ECsto NNP cord-005453-4057qib7 4857 16 support support NN cord-005453-4057qib7 4857 17 HSCs hscs NN cord-005453-4057qib7 4857 18 . . . cord-005453-4057qib7 4858 1 Therefore therefore RB cord-005453-4057qib7 4858 2 , , , cord-005453-4057qib7 4858 3 it -PRON- PRP cord-005453-4057qib7 4858 4 would would MD cord-005453-4057qib7 4858 5 be be VB cord-005453-4057qib7 4858 6 of of IN cord-005453-4057qib7 4858 7 value value NN cord-005453-4057qib7 4858 8 to to TO cord-005453-4057qib7 4858 9 investigate investigate VB cord-005453-4057qib7 4858 10 whether whether IN cord-005453-4057qib7 4858 11 upregulating upregulating NN cord-005453-4057qib7 4858 12 of of IN cord-005453-4057qib7 4858 13 cytoprotective cytoprotective JJ cord-005453-4057qib7 4858 14 autophagy autophagy NN cord-005453-4057qib7 4858 15 of of IN cord-005453-4057qib7 4858 16 BM BM NNP cord-005453-4057qib7 4858 17 ECs ECs NNP cord-005453-4057qib7 4858 18 may may MD cord-005453-4057qib7 4858 19 ameliorate ameliorate VB cord-005453-4057qib7 4858 20 PGF PGF NNP cord-005453-4057qib7 4858 21 , , , cord-005453-4057qib7 4858 22 thereby thereby RB cord-005453-4057qib7 4858 23 providing provide VBG cord-005453-4057qib7 4858 24 a a DT cord-005453-4057qib7 4858 25 novel novel JJ cord-005453-4057qib7 4858 26 clinical clinical JJ cord-005453-4057qib7 4858 27 intervention intervention NN cord-005453-4057qib7 4858 28 for for IN cord-005453-4057qib7 4858 29 PGF PGF NNP cord-005453-4057qib7 4858 30 in in IN cord-005453-4057qib7 4858 31 the the DT cord-005453-4057qib7 4858 32 future future NN cord-005453-4057qib7 4858 33 . . . cord-005453-4057qib7 4859 1 Clinical clinical JJ cord-005453-4057qib7 4859 2 Background background NN cord-005453-4057qib7 4859 3 : : : cord-005453-4057qib7 4859 4 Heparanase Heparanase NNP cord-005453-4057qib7 4859 5 ( ( -LRB- cord-005453-4057qib7 4859 6 HPSE HPSE NNP cord-005453-4057qib7 4859 7 ) ) -RRB- cord-005453-4057qib7 4859 8 in in IN cord-005453-4057qib7 4859 9 an an DT cord-005453-4057qib7 4859 10 endoβ endoβ NN cord-005453-4057qib7 4859 11 - - HYPH cord-005453-4057qib7 4859 12 glucuronidase glucuronidase NN cord-005453-4057qib7 4859 13 that that WDT cord-005453-4057qib7 4859 14 specifically specifically RB cord-005453-4057qib7 4859 15 cleaves cleave VBZ cord-005453-4057qib7 4859 16 the the DT cord-005453-4057qib7 4859 17 saccaride saccaride JJ cord-005453-4057qib7 4859 18 chains chain NNS cord-005453-4057qib7 4859 19 of of IN cord-005453-4057qib7 4859 20 heparan heparan JJ cord-005453-4057qib7 4859 21 sulphate sulphate NN cord-005453-4057qib7 4859 22 proteoglycans proteoglycan NNS cord-005453-4057qib7 4859 23 ( ( -LRB- cord-005453-4057qib7 4859 24 HS HS NNP cord-005453-4057qib7 4859 25 ) ) -RRB- cord-005453-4057qib7 4859 26 , , , cord-005453-4057qib7 4859 27 leading lead VBG cord-005453-4057qib7 4859 28 to to IN cord-005453-4057qib7 4859 29 a a DT cord-005453-4057qib7 4859 30 loss loss NN cord-005453-4057qib7 4859 31 of of IN cord-005453-4057qib7 4859 32 integrity integrity NN cord-005453-4057qib7 4859 33 of of IN cord-005453-4057qib7 4859 34 the the DT cord-005453-4057qib7 4859 35 extracellular extracellular JJ cord-005453-4057qib7 4859 36 matrix matrix NN cord-005453-4057qib7 4859 37 and and CC cord-005453-4057qib7 4859 38 to to TO cord-005453-4057qib7 4859 39 release release VB cord-005453-4057qib7 4859 40 of of IN cord-005453-4057qib7 4859 41 HS HS NNP cord-005453-4057qib7 4859 42 - - HYPH cord-005453-4057qib7 4859 43 bound bind VBN cord-005453-4057qib7 4859 44 cytokines cytokine NNS cord-005453-4057qib7 4859 45 , , , cord-005453-4057qib7 4859 46 chemokines chemokine NNS cord-005453-4057qib7 4859 47 , , , cord-005453-4057qib7 4859 48 angiogenic angiogenic NN cord-005453-4057qib7 4859 49 and and CC cord-005453-4057qib7 4859 50 growth growth NN cord-005453-4057qib7 4859 51 factors factor NNS cord-005453-4057qib7 4859 52 . . . cord-005453-4057qib7 4860 1 HPSE HPSE NNP cord-005453-4057qib7 4860 2 gene gene NN cord-005453-4057qib7 4860 3 is be VBZ cord-005453-4057qib7 4860 4 polymorphic polymorphic JJ cord-005453-4057qib7 4860 5 and and CC cord-005453-4057qib7 4860 6 includes include VBZ cord-005453-4057qib7 4860 7 approximately approximately RB cord-005453-4057qib7 4860 8 300 300 CD cord-005453-4057qib7 4860 9 SNPs snp NNS cord-005453-4057qib7 4860 10 . . . cord-005453-4057qib7 4861 1 The the DT cord-005453-4057qib7 4861 2 combination combination NN cord-005453-4057qib7 4861 3 of of IN cord-005453-4057qib7 4861 4 two two CD cord-005453-4057qib7 4861 5 SNPs SNPs NNPS cord-005453-4057qib7 4861 6 , , , cord-005453-4057qib7 4861 7 rs4693608 rs4693608 NNP cord-005453-4057qib7 4861 8 and and CC cord-005453-4057qib7 4861 9 rs4364254 rs4364254 NNP cord-005453-4057qib7 4861 10 , , , cord-005453-4057qib7 4861 11 are be VBP cord-005453-4057qib7 4861 12 involved involve VBN cord-005453-4057qib7 4861 13 in in IN cord-005453-4057qib7 4861 14 the the DT cord-005453-4057qib7 4861 15 regulation regulation NN cord-005453-4057qib7 4861 16 of of IN cord-005453-4057qib7 4861 17 HPSE HPSE NNP cord-005453-4057qib7 4861 18 expression expression NN cord-005453-4057qib7 4861 19 with with IN cord-005453-4057qib7 4861 20 an an DT cord-005453-4057qib7 4861 21 inverse inverse JJ cord-005453-4057qib7 4861 22 correlation correlation NN cord-005453-4057qib7 4861 23 between between IN cord-005453-4057qib7 4861 24 mRNA mRNA NNP cord-005453-4057qib7 4861 25 expression expression NN cord-005453-4057qib7 4861 26 and and CC cord-005453-4057qib7 4861 27 protein protein NN cord-005453-4057qib7 4861 28 levels level NNS cord-005453-4057qib7 4861 29 : : : cord-005453-4057qib7 4861 30 GG GG NNP cord-005453-4057qib7 4861 31 - - HYPH cord-005453-4057qib7 4861 32 CC CC NNP cord-005453-4057qib7 4861 33 , , , cord-005453-4057qib7 4861 34 GG GG NNP cord-005453-4057qib7 4861 35 - - HYPH cord-005453-4057qib7 4861 36 CT CT NNP cord-005453-4057qib7 4861 37 , , , cord-005453-4057qib7 4861 38 GG GG NNP cord-005453-4057qib7 4861 39 - - HYPH cord-005453-4057qib7 4861 40 TT TT NNP cord-005453-4057qib7 4861 41 , , , cord-005453-4057qib7 4861 42 GA GA NNP cord-005453-4057qib7 4861 43 - - HYPH cord-005453-4057qib7 4861 44 CC CC NNP cord-005453-4057qib7 4861 45 ( ( -LRB- cord-005453-4057qib7 4861 46 Low low JJ cord-005453-4057qib7 4861 47 group group NN cord-005453-4057qib7 4861 48 ) ) -RRB- cord-005453-4057qib7 4861 49 expressed express VBD cord-005453-4057qib7 4861 50 high high JJ cord-005453-4057qib7 4861 51 HPSE HPSE NNP cord-005453-4057qib7 4861 52 concentration concentration NN cord-005453-4057qib7 4861 53 ; ; : cord-005453-4057qib7 4861 54 GA GA NNP cord-005453-4057qib7 4861 55 - - HYPH cord-005453-4057qib7 4861 56 CT CT NNP cord-005453-4057qib7 4861 57 and and CC cord-005453-4057qib7 4861 58 GA GA NNP cord-005453-4057qib7 4861 59 - - HYPH cord-005453-4057qib7 4861 60 TT TT NNP cord-005453-4057qib7 4861 61 ( ( -LRB- cord-005453-4057qib7 4861 62 Median median JJ cord-005453-4057qib7 4861 63 group group NN cord-005453-4057qib7 4861 64 ) ) -RRB- cord-005453-4057qib7 4861 65 expressed express VBD cord-005453-4057qib7 4861 66 intermediate intermediate JJ cord-005453-4057qib7 4861 67 HPSE HPSE NNP cord-005453-4057qib7 4861 68 levels level NNS cord-005453-4057qib7 4861 69 ; ; : cord-005453-4057qib7 4861 70 AA AA NNP cord-005453-4057qib7 4861 71 - - HYPH cord-005453-4057qib7 4861 72 TT TT NNP cord-005453-4057qib7 4861 73 and and CC cord-005453-4057qib7 4861 74 AA AA NNP cord-005453-4057qib7 4861 75 - - HYPH cord-005453-4057qib7 4861 76 CT CT NNP cord-005453-4057qib7 4861 77 expressed express VBD cord-005453-4057qib7 4861 78 low low JJ cord-005453-4057qib7 4861 79 HPSE HPSE NNP cord-005453-4057qib7 4861 80 concentration concentration NN cord-005453-4057qib7 4861 81 ( ( -LRB- cord-005453-4057qib7 4861 82 High high JJ cord-005453-4057qib7 4861 83 group group NN cord-005453-4057qib7 4861 84 ) ) -RRB- cord-005453-4057qib7 4861 85 . . . cord-005453-4057qib7 4862 1 We -PRON- PRP cord-005453-4057qib7 4862 2 studied study VBD cord-005453-4057qib7 4862 3 HPSE HPSE NNP cord-005453-4057qib7 4862 4 SNPs snp NNS cord-005453-4057qib7 4862 5 in in IN cord-005453-4057qib7 4862 6 the the DT cord-005453-4057qib7 4862 7 allogeneic allogeneic NN cord-005453-4057qib7 4862 8 stem stem NN cord-005453-4057qib7 4862 9 cell cell NN cord-005453-4057qib7 4862 10 transplantation transplantation NN cord-005453-4057qib7 4862 11 ( ( -LRB- cord-005453-4057qib7 4862 12 HSCT HSCT NNP cord-005453-4057qib7 4862 13 ) ) -RRB- cord-005453-4057qib7 4862 14 setting set VBG cord-005453-4057qib7 4862 15 to to TO cord-005453-4057qib7 4862 16 evaluate evaluate VB cord-005453-4057qib7 4862 17 a a DT cord-005453-4057qib7 4862 18 possible possible JJ cord-005453-4057qib7 4862 19 association association NN cord-005453-4057qib7 4862 20 with with IN cord-005453-4057qib7 4862 21 post post JJ cord-005453-4057qib7 4862 22 - - JJ cord-005453-4057qib7 4862 23 HSCT hsct JJ cord-005453-4057qib7 4862 24 outcomes outcome NNS cord-005453-4057qib7 4862 25 . . . cord-005453-4057qib7 4863 1 Methods method NNS cord-005453-4057qib7 4863 2 : : : cord-005453-4057qib7 4863 3 We -PRON- PRP cord-005453-4057qib7 4863 4 enrolled enrol VBD cord-005453-4057qib7 4863 5 228 228 CD cord-005453-4057qib7 4863 6 patients patient NNS cord-005453-4057qib7 4863 7 submitted submit VBN cord-005453-4057qib7 4863 8 to to IN cord-005453-4057qib7 4863 9 HSCT HSCT NNP cord-005453-4057qib7 4863 10 in in IN cord-005453-4057qib7 4863 11 our -PRON- PRP$ cord-005453-4057qib7 4863 12 department department NN cord-005453-4057qib7 4863 13 since since IN cord-005453-4057qib7 4863 14 2005 2005 CD cord-005453-4057qib7 4863 15 to to IN cord-005453-4057qib7 4863 16 2016 2016 CD cord-005453-4057qib7 4863 17 . . . cord-005453-4057qib7 4864 1 For for IN cord-005453-4057qib7 4864 2 each each DT cord-005453-4057qib7 4864 3 couple couple NN cord-005453-4057qib7 4864 4 recipient recipient NN cord-005453-4057qib7 4864 5 - - HYPH cord-005453-4057qib7 4864 6 donor donor NN cord-005453-4057qib7 4864 7 , , , cord-005453-4057qib7 4864 8 rs4693608 rs4693608 NNP cord-005453-4057qib7 4864 9 SNP SNP NNP cord-005453-4057qib7 4864 10 was be VBD cord-005453-4057qib7 4864 11 genotyped genotype VBN cord-005453-4057qib7 4864 12 using use VBG cord-005453-4057qib7 4864 13 restriction restriction NN cord-005453-4057qib7 4864 14 fragment fragment NN cord-005453-4057qib7 4864 15 lenght lenght NN cord-005453-4057qib7 4864 16 polymorphism polymorphism NN cord-005453-4057qib7 4864 17 assay assay NN cord-005453-4057qib7 4864 18 , , , cord-005453-4057qib7 4864 19 whereas whereas IN cord-005453-4057qib7 4864 20 for for IN cord-005453-4057qib7 4864 21 rs4364254 rs4364254 NNP cord-005453-4057qib7 4864 22 SNP SNP NNP cord-005453-4057qib7 4864 23 an an DT cord-005453-4057qib7 4864 24 allele allele NN cord-005453-4057qib7 4864 25 - - HYPH cord-005453-4057qib7 4864 26 specific specific JJ cord-005453-4057qib7 4864 27 polimerase polimerase NN cord-005453-4057qib7 4864 28 chain chain NN cord-005453-4057qib7 4864 29 reaction reaction NN cord-005453-4057qib7 4864 30 was be VBD cord-005453-4057qib7 4864 31 applied apply VBN cord-005453-4057qib7 4864 32 . . . cord-005453-4057qib7 4865 1 HPSE HPSE NNP cord-005453-4057qib7 4865 2 genotype genotype NN cord-005453-4057qib7 4865 3 distribution distribution NN cord-005453-4057qib7 4865 4 was be VBD cord-005453-4057qib7 4865 5 compared compare VBN cord-005453-4057qib7 4865 6 in in IN cord-005453-4057qib7 4865 7 different different JJ cord-005453-4057qib7 4865 8 groups group NNS cord-005453-4057qib7 4865 9 according accord VBG cord-005453-4057qib7 4865 10 to to IN cord-005453-4057qib7 4865 11 post post JJ cord-005453-4057qib7 4865 12 - - JJ cord-005453-4057qib7 4865 13 HSCT hsct JJ cord-005453-4057qib7 4865 14 outcome outcome NN cord-005453-4057qib7 4865 15 : : : cord-005453-4057qib7 4865 16 graft graft NN cord-005453-4057qib7 4865 17 - - HYPH cord-005453-4057qib7 4865 18 versus versus IN cord-005453-4057qib7 4865 19 - - HYPH cord-005453-4057qib7 4865 20 host host NN cord-005453-4057qib7 4865 21 disease disease NN cord-005453-4057qib7 4865 22 ( ( -LRB- cord-005453-4057qib7 4865 23 GvHD GvHD NNP cord-005453-4057qib7 4865 24 ) ) -RRB- cord-005453-4057qib7 4865 25 , , , cord-005453-4057qib7 4865 26 transplantrelated transplantrelate VBN cord-005453-4057qib7 4865 27 mortality mortality NN cord-005453-4057qib7 4865 28 ( ( -LRB- cord-005453-4057qib7 4865 29 TRM TRM NNP cord-005453-4057qib7 4865 30 ) ) -RRB- cord-005453-4057qib7 4865 31 , , , cord-005453-4057qib7 4865 32 overall overall JJ cord-005453-4057qib7 4865 33 survival survival NN cord-005453-4057qib7 4865 34 ( ( -LRB- cord-005453-4057qib7 4865 35 OS OS NNP cord-005453-4057qib7 4865 36 ) ) -RRB- cord-005453-4057qib7 4865 37 , , , cord-005453-4057qib7 4865 38 infectious infectious JJ cord-005453-4057qib7 4865 39 complication complication NN cord-005453-4057qib7 4865 40 and and CC cord-005453-4057qib7 4865 41 disease disease NN cord-005453-4057qib7 4865 42 - - HYPH cord-005453-4057qib7 4865 43 free free JJ cord-005453-4057qib7 4865 44 survival survival NN cord-005453-4057qib7 4865 45 ( ( -LRB- cord-005453-4057qib7 4865 46 DFS DFS NNP cord-005453-4057qib7 4865 47 ) ) -RRB- cord-005453-4057qib7 4865 48 . . . cord-005453-4057qib7 4866 1 Statistical statistical JJ cord-005453-4057qib7 4866 2 analysis analysis NN cord-005453-4057qib7 4866 3 was be VBD cord-005453-4057qib7 4866 4 performed perform VBN cord-005453-4057qib7 4866 5 using use VBG cord-005453-4057qib7 4866 6 NCSS NCSS NNP cord-005453-4057qib7 4866 7 10 10 CD cord-005453-4057qib7 4866 8 . . . cord-005453-4057qib7 4867 1 Results result NNS cord-005453-4057qib7 4867 2 : : : cord-005453-4057qib7 4868 1 Distribution distribution NN cord-005453-4057qib7 4868 2 of of IN cord-005453-4057qib7 4868 3 rs4693608 rs4693608 NNP cord-005453-4057qib7 4868 4 SNP SNP NNP cord-005453-4057qib7 4868 5 was be VBD cord-005453-4057qib7 4868 6 as as IN cord-005453-4057qib7 4868 7 follows follow VBZ cord-005453-4057qib7 4868 8 : : : cord-005453-4057qib7 4868 9 GG GG NNP cord-005453-4057qib7 4868 10 16.7 16.7 CD cord-005453-4057qib7 4868 11 % % NN cord-005453-4057qib7 4868 12 , , , cord-005453-4057qib7 4868 13 GA GA NNP cord-005453-4057qib7 4868 14 49.8 49.8 CD cord-005453-4057qib7 4868 15 % % NN cord-005453-4057qib7 4868 16 and and CC cord-005453-4057qib7 4868 17 AA AA NNP cord-005453-4057qib7 4868 18 33.5 33.5 CD cord-005453-4057qib7 4868 19 % % NN cord-005453-4057qib7 4868 20 among among IN cord-005453-4057qib7 4868 21 recipients recipient NNS cord-005453-4057qib7 4868 22 and and CC cord-005453-4057qib7 4868 23 17.6 17.6 CD cord-005453-4057qib7 4868 24 % % NN cord-005453-4057qib7 4868 25 , , , cord-005453-4057qib7 4868 26 53.3 53.3 CD cord-005453-4057qib7 4868 27 % % NN cord-005453-4057qib7 4868 28 and and CC cord-005453-4057qib7 4868 29 29.1 29.1 CD cord-005453-4057qib7 4868 30 % % NN cord-005453-4057qib7 4868 31 among among IN cord-005453-4057qib7 4868 32 donors donor NNS cord-005453-4057qib7 4868 33 , , , cord-005453-4057qib7 4868 34 respectively respectively RB cord-005453-4057qib7 4868 35 . . . cord-005453-4057qib7 4869 1 Hardy Hardy NNP cord-005453-4057qib7 4869 2 - - HYPH cord-005453-4057qib7 4869 3 Weinberg Weinberg NNP cord-005453-4057qib7 4869 4 equilibrium equilibrium NN cord-005453-4057qib7 4869 5 ( ( -LRB- cord-005453-4057qib7 4869 6 HWe HWe NNS cord-005453-4057qib7 4869 7 ) ) -RRB- cord-005453-4057qib7 4869 8 was be VBD cord-005453-4057qib7 4869 9 respected respect VBN cord-005453-4057qib7 4869 10 . . . cord-005453-4057qib7 4870 1 Distribution distribution NN cord-005453-4057qib7 4870 2 of of IN cord-005453-4057qib7 4870 3 rs4364254 rs4364254 NNP cord-005453-4057qib7 4870 4 SNP SNP NNP cord-005453-4057qib7 4870 5 was be VBD cord-005453-4057qib7 4870 6 as as IN cord-005453-4057qib7 4870 7 follows follow VBZ cord-005453-4057qib7 4870 8 : : : cord-005453-4057qib7 4870 9 CC CC NNP cord-005453-4057qib7 4870 10 15.1 15.1 CD cord-005453-4057qib7 4870 11 % % NN cord-005453-4057qib7 4870 12 , , , cord-005453-4057qib7 4870 13 CT CT NNP cord-005453-4057qib7 4870 14 37.8 37.8 CD cord-005453-4057qib7 4870 15 % % NN cord-005453-4057qib7 4870 16 and and CC cord-005453-4057qib7 4870 17 TT TT NNP cord-005453-4057qib7 4870 18 37.8 37.8 CD cord-005453-4057qib7 4870 19 % % NN cord-005453-4057qib7 4870 20 among among IN cord-005453-4057qib7 4870 21 recipients recipient NNS cord-005453-4057qib7 4870 22 and and CC cord-005453-4057qib7 4870 23 15.3 15.3 CD cord-005453-4057qib7 4870 24 % % NN cord-005453-4057qib7 4870 25 , , , cord-005453-4057qib7 4870 26 36 36 CD cord-005453-4057qib7 4870 27 % % NN cord-005453-4057qib7 4870 28 and and CC cord-005453-4057qib7 4870 29 48.7 48.7 CD cord-005453-4057qib7 4870 30 % % NN cord-005453-4057qib7 4870 31 among among IN cord-005453-4057qib7 4870 32 donors donor NNS cord-005453-4057qib7 4870 33 , , , cord-005453-4057qib7 4870 34 respectively respectively RB cord-005453-4057qib7 4870 35 . . . cord-005453-4057qib7 4871 1 rs4364254 rs4364254 NNP cord-005453-4057qib7 4871 2 SNP SNP NNP cord-005453-4057qib7 4871 3 distribution distribution NN cord-005453-4057qib7 4871 4 did do VBD cord-005453-4057qib7 4871 5 not not RB cord-005453-4057qib7 4871 6 respect respect VB cord-005453-4057qib7 4871 7 the the DT cord-005453-4057qib7 4871 8 HWe HWe NNS cord-005453-4057qib7 4871 9 . . . cord-005453-4057qib7 4872 1 An an DT cord-005453-4057qib7 4872 2 association association NN cord-005453-4057qib7 4872 3 was be VBD cord-005453-4057qib7 4872 4 found find VBN cord-005453-4057qib7 4872 5 between between IN cord-005453-4057qib7 4872 6 recipient recipient NN cord-005453-4057qib7 4872 7 rs4364254 rs4364254 NNP cord-005453-4057qib7 4872 8 SNP SNP NNP cord-005453-4057qib7 4872 9 and and CC cord-005453-4057qib7 4872 10 the the DT cord-005453-4057qib7 4872 11 cumulative cumulative JJ cord-005453-4057qib7 4872 12 incidence incidence NN cord-005453-4057qib7 4872 13 of of IN cord-005453-4057qib7 4872 14 aGvHD agvhd NN cord-005453-4057qib7 4872 15 among among IN cord-005453-4057qib7 4872 16 patients patient NNS cord-005453-4057qib7 4872 17 submitted submit VBN cord-005453-4057qib7 4872 18 to to IN cord-005453-4057qib7 4872 19 a a DT cord-005453-4057qib7 4872 20 reduced reduce VBN cord-005453-4057qib7 4872 21 intensity intensity NN cord-005453-4057qib7 4872 22 conditioning conditioning NN cord-005453-4057qib7 4872 23 ( ( -LRB- cord-005453-4057qib7 4872 24 RIC RIC NNP cord-005453-4057qib7 4872 25 ) ) -RRB- cord-005453-4057qib7 4872 26 : : : cord-005453-4057qib7 4872 27 37.3 37.3 CD cord-005453-4057qib7 4872 28 % % NN cord-005453-4057qib7 4872 29 for for IN cord-005453-4057qib7 4872 30 TT TT NNP cord-005453-4057qib7 4872 31 genotype genotype NN cord-005453-4057qib7 4872 32 and and CC cord-005453-4057qib7 4872 33 69 69 CD cord-005453-4057qib7 4872 34 % % NN cord-005453-4057qib7 4872 35 for for IN cord-005453-4057qib7 4872 36 CT CT NNP cord-005453-4057qib7 4872 37 or or CC cord-005453-4057qib7 4872 38 CC CC NNP cord-005453-4057qib7 4872 39 genotype genotype NN cord-005453-4057qib7 4872 40 ( ( -LRB- cord-005453-4057qib7 4872 41 p=0.03 p=0.03 NN cord-005453-4057qib7 4872 42 ) ) -RRB- cord-005453-4057qib7 4872 43 . . . cord-005453-4057qib7 4873 1 on on IN cord-005453-4057qib7 4873 2 the the DT cord-005453-4057qib7 4873 3 other other JJ cord-005453-4057qib7 4873 4 hand hand NN cord-005453-4057qib7 4873 5 , , , cord-005453-4057qib7 4873 6 an an DT cord-005453-4057qib7 4873 7 association association NN cord-005453-4057qib7 4873 8 was be VBD cord-005453-4057qib7 4873 9 identified identify VBN cord-005453-4057qib7 4873 10 between between IN cord-005453-4057qib7 4873 11 donor donor NN cord-005453-4057qib7 4873 12 rs4693608 rs4693608 NNP cord-005453-4057qib7 4873 13 / / , cord-005453-4057qib7 4873 14 rs4364254 rs4364254 NNP cord-005453-4057qib7 4873 15 SNPs SNPs NNPS cord-005453-4057qib7 4873 16 combination combination NN cord-005453-4057qib7 4873 17 and and CC cord-005453-4057qib7 4873 18 the the DT cord-005453-4057qib7 4873 19 cumulative cumulative JJ cord-005453-4057qib7 4873 20 incidence incidence NN cord-005453-4057qib7 4873 21 of of IN cord-005453-4057qib7 4873 22 aGvHD agvhd NN cord-005453-4057qib7 4873 23 : : : cord-005453-4057qib7 4873 24 81.5 81.5 CD cord-005453-4057qib7 4873 25 % % NN cord-005453-4057qib7 4873 26 for for IN cord-005453-4057qib7 4873 27 Low low JJ cord-005453-4057qib7 4873 28 group group NN cord-005453-4057qib7 4873 29 donor donor NN cord-005453-4057qib7 4873 30 , , , cord-005453-4057qib7 4873 31 48 48 CD cord-005453-4057qib7 4873 32 % % NN cord-005453-4057qib7 4873 33 for for IN cord-005453-4057qib7 4873 34 Median median JJ cord-005453-4057qib7 4873 35 group group NN cord-005453-4057qib7 4873 36 donor donor NN cord-005453-4057qib7 4873 37 and and CC cord-005453-4057qib7 4873 38 40.8 40.8 CD cord-005453-4057qib7 4873 39 % % NN cord-005453-4057qib7 4873 40 for for IN cord-005453-4057qib7 4873 41 High high JJ cord-005453-4057qib7 4873 42 group group NN cord-005453-4057qib7 4873 43 donor donor NN cord-005453-4057qib7 4873 44 ( ( -LRB- cord-005453-4057qib7 4873 45 p=0.04 p=0.04 NNP cord-005453-4057qib7 4873 46 ) ) -RRB- cord-005453-4057qib7 4873 47 . . . cord-005453-4057qib7 4874 1 Conversely conversely RB cord-005453-4057qib7 4874 2 , , , cord-005453-4057qib7 4874 3 AA AA NNP cord-005453-4057qib7 4874 4 genotype genotype NN cord-005453-4057qib7 4874 5 for for IN cord-005453-4057qib7 4874 6 donor donor NN cord-005453-4057qib7 4874 7 rs4693608 rs4693608 NNP cord-005453-4057qib7 4874 8 resulted result VBD cord-005453-4057qib7 4874 9 independent independent JJ cord-005453-4057qib7 4874 10 risk risk NN cord-005453-4057qib7 4874 11 factor factor NN cord-005453-4057qib7 4874 12 for for IN cord-005453-4057qib7 4874 13 cGvHD cGvHD NNP cord-005453-4057qib7 4874 14 de de FW cord-005453-4057qib7 4874 15 novo novo NNP cord-005453-4057qib7 4874 16 development development NN cord-005453-4057qib7 4874 17 ( ( -LRB- cord-005453-4057qib7 4874 18 p=0.049 p=0.049 NNP cord-005453-4057qib7 4874 19 , , , cord-005453-4057qib7 4874 20 OD OD NNP cord-005453-4057qib7 4874 21 2.1 2.1 CD cord-005453-4057qib7 4874 22 ) ) -RRB- cord-005453-4057qib7 4874 23 together together RB cord-005453-4057qib7 4874 24 to to IN cord-005453-4057qib7 4874 25 donor donor NN cord-005453-4057qib7 4874 26 - - HYPH cord-005453-4057qib7 4874 27 recipient recipient NN cord-005453-4057qib7 4874 28 sex sex NN cord-005453-4057qib7 4874 29 mismatch mismatch NN cord-005453-4057qib7 4874 30 ( ( -LRB- cord-005453-4057qib7 4874 31 female female JJ cord-005453-4057qib7 4874 32 donor donor NN cord-005453-4057qib7 4874 33 to to IN cord-005453-4057qib7 4874 34 male male JJ cord-005453-4057qib7 4874 35 recipient recipient NN cord-005453-4057qib7 4874 36 vs. vs. FW cord-005453-4057qib7 4874 37 others other NNS cord-005453-4057qib7 4874 38 : : : cord-005453-4057qib7 4875 1 p=0.005 p=0.005 NNP cord-005453-4057qib7 4875 2 , , , cord-005453-4057qib7 4875 3 OD OD NNP cord-005453-4057qib7 4875 4 3.56 3.56 CD cord-005453-4057qib7 4875 5 ) ) -RRB- cord-005453-4057qib7 4875 6 . . . cord-005453-4057qib7 4876 1 Considering consider VBG cord-005453-4057qib7 4876 2 CMV CMV NNP cord-005453-4057qib7 4876 3 reactivation reactivation NN cord-005453-4057qib7 4876 4 rate rate NN cord-005453-4057qib7 4876 5 after after IN cord-005453-4057qib7 4876 6 HSCT HSCT NNP cord-005453-4057qib7 4876 7 , , , cord-005453-4057qib7 4876 8 an an DT cord-005453-4057qib7 4876 9 association association NN cord-005453-4057qib7 4876 10 was be VBD cord-005453-4057qib7 4876 11 observed observe VBN cord-005453-4057qib7 4876 12 according accord VBG cord-005453-4057qib7 4876 13 to to IN cord-005453-4057qib7 4876 14 recipient recipient NN cord-005453-4057qib7 4876 15 rs4364254 rs4364254 NNP cord-005453-4057qib7 4876 16 SNP SNP NNP cord-005453-4057qib7 4876 17 : : : cord-005453-4057qib7 4877 1 82 82 CD cord-005453-4057qib7 4877 2 % % NN cord-005453-4057qib7 4877 3 for for IN cord-005453-4057qib7 4877 4 CC CC NNP cord-005453-4057qib7 4877 5 genotype genotype NN cord-005453-4057qib7 4877 6 , , , cord-005453-4057qib7 4877 7 63.5 63.5 CD cord-005453-4057qib7 4877 8 % % NN cord-005453-4057qib7 4877 9 for for IN cord-005453-4057qib7 4877 10 CT CT NNP cord-005453-4057qib7 4877 11 genotype genotype NN cord-005453-4057qib7 4877 12 and and CC cord-005453-4057qib7 4877 13 57.1 57.1 CD cord-005453-4057qib7 4877 14 % % NN cord-005453-4057qib7 4877 15 for for IN cord-005453-4057qib7 4877 16 TT TT NNP cord-005453-4057qib7 4877 17 genotype genotype NN cord-005453-4057qib7 4877 18 ( ( -LRB- cord-005453-4057qib7 4877 19 p=0.049 p=0.049 NNP cord-005453-4057qib7 4877 20 ) ) -RRB- cord-005453-4057qib7 4877 21 . . . cord-005453-4057qib7 4878 1 Multivariate multivariate JJ cord-005453-4057qib7 4878 2 analysis analysis NN cord-005453-4057qib7 4878 3 confirmed confirm VBD cord-005453-4057qib7 4878 4 recipient recipient NN cord-005453-4057qib7 4878 5 rs4364254 rs4364254 NNP cord-005453-4057qib7 4878 6 SNP SNP NNP cord-005453-4057qib7 4878 7 as as IN cord-005453-4057qib7 4878 8 independent independent JJ cord-005453-4057qib7 4878 9 risk risk NN cord-005453-4057qib7 4878 10 factor factor NN cord-005453-4057qib7 4878 11 for for IN cord-005453-4057qib7 4878 12 CMV CMV NNP cord-005453-4057qib7 4878 13 reactivation reactivation NN cord-005453-4057qib7 4878 14 after after IN cord-005453-4057qib7 4878 15 HSCT HSCT NNP cord-005453-4057qib7 4878 16 ( ( -LRB- cord-005453-4057qib7 4878 17 p=0.04 p=0.04 NNP cord-005453-4057qib7 4878 18 , , , cord-005453-4057qib7 4878 19 OD OD NNP cord-005453-4057qib7 4878 20 2.62 2.62 CD cord-005453-4057qib7 4878 21 ) ) -RRB- cord-005453-4057qib7 4878 22 together together RB cord-005453-4057qib7 4878 23 with with IN cord-005453-4057qib7 4878 24 recipient recipient NN cord-005453-4057qib7 4878 25 CMV CMV NNP cord-005453-4057qib7 4878 26 serostatus serostatus NN cord-005453-4057qib7 4878 27 at at IN cord-005453-4057qib7 4878 28 transplant transplant NN cord-005453-4057qib7 4878 29 ( ( -LRB- cord-005453-4057qib7 4878 30 positive positive JJ cord-005453-4057qib7 4878 31 vs. vs. FW cord-005453-4057qib7 4878 32 negative negative JJ cord-005453-4057qib7 4878 33 : : : cord-005453-4057qib7 4878 34 p p NN cord-005453-4057qib7 4878 35 < < XX cord-005453-4057qib7 4878 36 0.01 0.01 CD cord-005453-4057qib7 4878 37 , , , cord-005453-4057qib7 4878 38 OD OD NNP cord-005453-4057qib7 4878 39 8.49 8.49 CD cord-005453-4057qib7 4878 40 ) ) -RRB- cord-005453-4057qib7 4878 41 . . . cord-005453-4057qib7 4879 1 Conclusions conclusion NNS cord-005453-4057qib7 4879 2 : : : cord-005453-4057qib7 4880 1 HPSE HPSE NNP cord-005453-4057qib7 4880 2 role role NN cord-005453-4057qib7 4880 3 was be VBD cord-005453-4057qib7 4880 4 widely widely RB cord-005453-4057qib7 4880 5 studied study VBN cord-005453-4057qib7 4880 6 in in IN cord-005453-4057qib7 4880 7 the the DT cord-005453-4057qib7 4880 8 setting setting NN cord-005453-4057qib7 4880 9 of of IN cord-005453-4057qib7 4880 10 inflammation inflammation NN cord-005453-4057qib7 4880 11 , , , cord-005453-4057qib7 4880 12 autoimmune autoimmune JJ cord-005453-4057qib7 4880 13 diseases disease NNS cord-005453-4057qib7 4880 14 , , , cord-005453-4057qib7 4880 15 hematological hematological JJ cord-005453-4057qib7 4880 16 disease disease NN cord-005453-4057qib7 4880 17 and and CC cord-005453-4057qib7 4880 18 tumor tumor NN cord-005453-4057qib7 4880 19 . . . cord-005453-4057qib7 4881 1 However however RB cord-005453-4057qib7 4881 2 , , , cord-005453-4057qib7 4881 3 it -PRON- PRP cord-005453-4057qib7 4881 4 still still RB cord-005453-4057qib7 4881 5 remains remain VBZ cord-005453-4057qib7 4881 6 debated debate VBN cord-005453-4057qib7 4881 7 the the DT cord-005453-4057qib7 4881 8 inducing inducing JJ cord-005453-4057qib7 4881 9 or or CC cord-005453-4057qib7 4881 10 protective protective JJ cord-005453-4057qib7 4881 11 activity activity NN cord-005453-4057qib7 4881 12 of of IN cord-005453-4057qib7 4881 13 HPSE HPSE NNP cord-005453-4057qib7 4881 14 in in IN cord-005453-4057qib7 4881 15 the the DT cord-005453-4057qib7 4881 16 setting setting NN cord-005453-4057qib7 4881 17 of of IN cord-005453-4057qib7 4881 18 GvHD GvHD NNP cord-005453-4057qib7 4881 19 . . . cord-005453-4057qib7 4882 1 Obviously obviously RB cord-005453-4057qib7 4882 2 , , , cord-005453-4057qib7 4882 3 our -PRON- PRP$ cord-005453-4057qib7 4882 4 results result NNS cord-005453-4057qib7 4882 5 need need VBP cord-005453-4057qib7 4882 6 to to TO cord-005453-4057qib7 4882 7 be be VB cord-005453-4057qib7 4882 8 confirmed confirm VBN cord-005453-4057qib7 4882 9 in in IN cord-005453-4057qib7 4882 10 a a DT cord-005453-4057qib7 4882 11 validation validation NN cord-005453-4057qib7 4882 12 cohort cohort NN cord-005453-4057qib7 4882 13 . . . cord-005453-4057qib7 4883 1 Clinical clinical JJ cord-005453-4057qib7 4883 2 Trial Trial NNP cord-005453-4057qib7 4883 3 Registry Registry NNP cord-005453-4057qib7 4883 4 : : : cord-005453-4057qib7 4884 1 NA NA NNP cord-005453-4057qib7 4884 2 Disclosure disclosure NN cord-005453-4057qib7 4884 3 : : : cord-005453-4057qib7 4884 4 Nothing nothing NN cord-005453-4057qib7 4884 5 to to TO cord-005453-4057qib7 4884 6 declare declare VB cord-005453-4057qib7 4884 7 Novel Novel NNP cord-005453-4057qib7 4884 8 protocol protocol NN cord-005453-4057qib7 4884 9 for for IN cord-005453-4057qib7 4884 10 autologous autologous JJ cord-005453-4057qib7 4884 11 HSCT HSCT NNP cord-005453-4057qib7 4884 12 in in IN cord-005453-4057qib7 4884 13 patients patient NNS cord-005453-4057qib7 4884 14 with with IN cord-005453-4057qib7 4884 15 high high JJ cord-005453-4057qib7 4884 16 risk risk NN cord-005453-4057qib7 4884 17 of of IN cord-005453-4057qib7 4884 18 complications complication NNS cord-005453-4057qib7 4884 19 : : : cord-005453-4057qib7 4885 1 Ambulatory ambulatory JJ cord-005453-4057qib7 4885 2 chemomobilization chemomobilization NN cord-005453-4057qib7 4885 3 and and CC cord-005453-4057qib7 4885 4 transplantation transplantation NN cord-005453-4057qib7 4885 5 of of IN cord-005453-4057qib7 4885 6 fresh fresh JJ cord-005453-4057qib7 4885 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 4885 8 stem stem NN cord-005453-4057qib7 4885 9 cells cell NNS cord-005453-4057qib7 4885 10 with with IN cord-005453-4057qib7 4885 11 backup backup JJ cord-005453-4057qib7 4885 12 storage storage NN cord-005453-4057qib7 4885 13 Background background NN cord-005453-4057qib7 4885 14 : : : cord-005453-4057qib7 4885 15 Autologous autologous JJ cord-005453-4057qib7 4885 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 4885 17 stem stem NN cord-005453-4057qib7 4885 18 cell cell NN cord-005453-4057qib7 4885 19 transplantation transplantation NN cord-005453-4057qib7 4885 20 ( ( -LRB- cord-005453-4057qib7 4885 21 AHSCT AHSCT NNP cord-005453-4057qib7 4885 22 ) ) -RRB- cord-005453-4057qib7 4885 23 is be VBZ cord-005453-4057qib7 4885 24 standard standard JJ cord-005453-4057qib7 4885 25 of of IN cord-005453-4057qib7 4885 26 treatment treatment NN cord-005453-4057qib7 4885 27 in in IN cord-005453-4057qib7 4885 28 many many JJ cord-005453-4057qib7 4885 29 patients patient NNS cord-005453-4057qib7 4885 30 with with IN cord-005453-4057qib7 4885 31 high high JJ cord-005453-4057qib7 4885 32 risk risk NN cord-005453-4057qib7 4885 33 of of IN cord-005453-4057qib7 4885 34 complications complication NNS cord-005453-4057qib7 4885 35 : : : cord-005453-4057qib7 4885 36 dialysed dialyse VBN cord-005453-4057qib7 4885 37 patients patient NNS cord-005453-4057qib7 4885 38 , , , cord-005453-4057qib7 4885 39 patients patient NNS cord-005453-4057qib7 4885 40 with with IN cord-005453-4057qib7 4885 41 heart heart NN cord-005453-4057qib7 4885 42 and and CC cord-005453-4057qib7 4885 43 kidney kidney NN cord-005453-4057qib7 4885 44 amyloidosis amyloidosis NN cord-005453-4057qib7 4885 45 or or CC cord-005453-4057qib7 4885 46 patients patient NNS cord-005453-4057qib7 4885 47 with with IN cord-005453-4057qib7 4885 48 systemic systemic JJ cord-005453-4057qib7 4885 49 sclerosis sclerosis NN cord-005453-4057qib7 4885 50 . . . cord-005453-4057qib7 4886 1 We -PRON- PRP cord-005453-4057qib7 4886 2 introduced introduce VBD cord-005453-4057qib7 4886 3 recently recently RB cord-005453-4057qib7 4886 4 a a DT cord-005453-4057qib7 4886 5 novel novel JJ cord-005453-4057qib7 4886 6 protocol protocol NN cord-005453-4057qib7 4886 7 for for IN cord-005453-4057qib7 4886 8 AHSCT AHSCT NNP cord-005453-4057qib7 4886 9 : : : cord-005453-4057qib7 4886 10 combination combination NN cord-005453-4057qib7 4886 11 of of IN cord-005453-4057qib7 4886 12 ambulatory ambulatory JJ cord-005453-4057qib7 4886 13 mobilization mobilization NN cord-005453-4057qib7 4886 14 with with IN cord-005453-4057qib7 4886 15 very very RB cord-005453-4057qib7 4886 16 low low JJ cord-005453-4057qib7 4886 17 doses dose NNS cord-005453-4057qib7 4886 18 of of IN cord-005453-4057qib7 4886 19 Ara Ara NNP cord-005453-4057qib7 4886 20 - - HYPH cord-005453-4057qib7 4886 21 C C NNP cord-005453-4057qib7 4886 22 and and CC cord-005453-4057qib7 4886 23 G G NNP cord-005453-4057qib7 4886 24 - - HYPH cord-005453-4057qib7 4886 25 CSF csf NN cord-005453-4057qib7 4886 26 connected connect VBN cord-005453-4057qib7 4886 27 with with IN cord-005453-4057qib7 4886 28 direct direct JJ cord-005453-4057qib7 4886 29 AHSCT AHSCT NNP cord-005453-4057qib7 4886 30 with with IN cord-005453-4057qib7 4886 31 fresh fresh JJ cord-005453-4057qib7 4886 32 cells cell NNS cord-005453-4057qib7 4886 33 . . . cord-005453-4057qib7 4887 1 This this DT cord-005453-4057qib7 4887 2 protocol protocol NN cord-005453-4057qib7 4887 3 allowed allow VBD cord-005453-4057qib7 4887 4 us -PRON- PRP cord-005453-4057qib7 4887 5 to to TO cord-005453-4057qib7 4887 6 reduce reduce VB cord-005453-4057qib7 4887 7 the the DT cord-005453-4057qib7 4887 8 transplant transplant NN cord-005453-4057qib7 4887 9 risk risk NN cord-005453-4057qib7 4887 10 in in IN cord-005453-4057qib7 4887 11 various various JJ cord-005453-4057qib7 4887 12 patient patient NN cord-005453-4057qib7 4887 13 groups group NNS cord-005453-4057qib7 4887 14 traditionally traditionally RB cord-005453-4057qib7 4887 15 connected connect VBN cord-005453-4057qib7 4887 16 with with IN cord-005453-4057qib7 4887 17 high high JJ cord-005453-4057qib7 4887 18 risk risk NN cord-005453-4057qib7 4887 19 of of IN cord-005453-4057qib7 4887 20 complications complication NNS cord-005453-4057qib7 4887 21 . . . cord-005453-4057qib7 4888 1 In in IN cord-005453-4057qib7 4888 2 this this DT cord-005453-4057qib7 4888 3 work work NN cord-005453-4057qib7 4888 4 we -PRON- PRP cord-005453-4057qib7 4888 5 summarize summarize VBP cord-005453-4057qib7 4888 6 the the DT cord-005453-4057qib7 4888 7 experience experience NN cord-005453-4057qib7 4888 8 in in IN cord-005453-4057qib7 4888 9 such such JJ cord-005453-4057qib7 4888 10 high high JJ cord-005453-4057qib7 4888 11 risk risk NN cord-005453-4057qib7 4888 12 patients patient NNS cord-005453-4057qib7 4888 13 . . . cord-005453-4057qib7 4889 1 Methods method NNS cord-005453-4057qib7 4889 2 : : : cord-005453-4057qib7 4890 1 The the DT cord-005453-4057qib7 4890 2 prospectively prospectively RB cord-005453-4057qib7 4890 3 collected collect VBN cord-005453-4057qib7 4890 4 database database NN cord-005453-4057qib7 4890 5 of of IN cord-005453-4057qib7 4890 6 patients patient NNS cord-005453-4057qib7 4890 7 after after IN cord-005453-4057qib7 4890 8 AHSCT AHSCT NNP cord-005453-4057qib7 4890 9 was be VBD cord-005453-4057qib7 4890 10 searched search VBN cord-005453-4057qib7 4890 11 for for IN cord-005453-4057qib7 4890 12 patients patient NNS cord-005453-4057qib7 4890 13 who who WP cord-005453-4057qib7 4890 14 underwent undergo VBD cord-005453-4057qib7 4890 15 AHSCT AHSCT NNP cord-005453-4057qib7 4890 16 after after IN cord-005453-4057qib7 4890 17 chemomobilization chemomobilization NN cord-005453-4057qib7 4890 18 with with IN cord-005453-4057qib7 4890 19 Ara Ara NNP cord-005453-4057qib7 4890 20 - - HYPH cord-005453-4057qib7 4890 21 C C NNP cord-005453-4057qib7 4890 22 and and CC cord-005453-4057qib7 4890 23 transplantation transplantation NN cord-005453-4057qib7 4890 24 with with IN cord-005453-4057qib7 4890 25 fresh fresh JJ cord-005453-4057qib7 4890 26 cells cell NNS cord-005453-4057qib7 4890 27 and and CC cord-005453-4057qib7 4890 28 who who WP cord-005453-4057qib7 4890 29 fulfilled fulfil VBD cord-005453-4057qib7 4890 30 at at IN cord-005453-4057qib7 4890 31 least least RBS cord-005453-4057qib7 4890 32 one one CD cord-005453-4057qib7 4890 33 study study NN cord-005453-4057qib7 4890 34 inclusion inclusion NN cord-005453-4057qib7 4890 35 criteria criterion NNS cord-005453-4057qib7 4890 36 : : : cord-005453-4057qib7 4890 37 a a LS cord-005453-4057qib7 4890 38 ) ) -RRB- cord-005453-4057qib7 4890 39 dependence dependence NN cord-005453-4057qib7 4890 40 on on IN cord-005453-4057qib7 4890 41 dialysis dialysis NN cord-005453-4057qib7 4890 42 b b NN cord-005453-4057qib7 4890 43 ) ) -RRB- cord-005453-4057qib7 4890 44 amyloidosis amyloidosis NN cord-005453-4057qib7 4890 45 c c NN cord-005453-4057qib7 4890 46 ) ) -RRB- cord-005453-4057qib7 4890 47 systemic systemic JJ cord-005453-4057qib7 4890 48 sclerosis sclerosis NNP cord-005453-4057qib7 4890 49 d d NN cord-005453-4057qib7 4890 50 ) ) -RRB- cord-005453-4057qib7 4890 51 disqualification disqualification NN cord-005453-4057qib7 4890 52 from from IN cord-005453-4057qib7 4890 53 transplantation transplantation NN cord-005453-4057qib7 4890 54 at at IN cord-005453-4057qib7 4890 55 other other JJ cord-005453-4057qib7 4890 56 centre centre NN cord-005453-4057qib7 4890 57 due due IN cord-005453-4057qib7 4890 58 to to IN cord-005453-4057qib7 4890 59 the the DT cord-005453-4057qib7 4890 60 high high JJ cord-005453-4057qib7 4890 61 risk risk NN cord-005453-4057qib7 4890 62 of of IN cord-005453-4057qib7 4890 63 complications complication NNS cord-005453-4057qib7 4890 64 . . . cord-005453-4057qib7 4891 1 There there EX cord-005453-4057qib7 4891 2 were be VBD cord-005453-4057qib7 4891 3 together together RB cord-005453-4057qib7 4891 4 19 19 CD cord-005453-4057qib7 4891 5 patients patient NNS cord-005453-4057qib7 4891 6 selected select VBN cord-005453-4057qib7 4891 7 for for IN cord-005453-4057qib7 4891 8 this this DT cord-005453-4057qib7 4891 9 analysis analysis NN cord-005453-4057qib7 4891 10 -9 -9 NN cord-005453-4057qib7 4891 11 with with IN cord-005453-4057qib7 4891 12 amyloidosis amyloidosis NN cord-005453-4057qib7 4891 13 ( ( -LRB- cord-005453-4057qib7 4891 14 6 6 CD cord-005453-4057qib7 4891 15 with with IN cord-005453-4057qib7 4891 16 ≥ ≥ CD cord-005453-4057qib7 4891 17 2 2 CD cord-005453-4057qib7 4891 18 organs organ NNS cord-005453-4057qib7 4891 19 involved involve VBN cord-005453-4057qib7 4891 20 ) ) -RRB- cord-005453-4057qib7 4891 21 , , , cord-005453-4057qib7 4891 22 9 9 CD cord-005453-4057qib7 4891 23 dialysed dialyse VBD cord-005453-4057qib7 4891 24 , , , cord-005453-4057qib7 4891 25 2 2 CD cord-005453-4057qib7 4891 26 with with IN cord-005453-4057qib7 4891 27 systemic systemic JJ cord-005453-4057qib7 4891 28 sclerosis sclerosis NN cord-005453-4057qib7 4891 29 , , , cord-005453-4057qib7 4891 30 2 2 CD cord-005453-4057qib7 4891 31 unfit unfit JJ cord-005453-4057qib7 4891 32 at at IN cord-005453-4057qib7 4891 33 other other JJ cord-005453-4057qib7 4891 34 centre centre NN cord-005453-4057qib7 4891 35 . . . cord-005453-4057qib7 4892 1 The the DT cord-005453-4057qib7 4892 2 database database NN cord-005453-4057qib7 4892 3 included include VBD cord-005453-4057qib7 4892 4 prospectively prospectively RB cord-005453-4057qib7 4892 5 recorded record VBN cord-005453-4057qib7 4892 6 serious serious JJ cord-005453-4057qib7 4892 7 adverse adverse JJ cord-005453-4057qib7 4892 8 events event NNS cord-005453-4057qib7 4892 9 during during IN cord-005453-4057qib7 4892 10 the the DT cord-005453-4057qib7 4892 11 mobilization mobilization NN cord-005453-4057qib7 4892 12 and and CC cord-005453-4057qib7 4892 13 transplantation transplantation NN cord-005453-4057qib7 4892 14 . . . cord-005453-4057qib7 4893 1 Results result NNS cord-005453-4057qib7 4893 2 : : : cord-005453-4057qib7 4894 1 There there EX cord-005453-4057qib7 4894 2 were be VBD cord-005453-4057qib7 4894 3 20 20 CD cord-005453-4057qib7 4894 4 transplantations transplantation NNS cord-005453-4057qib7 4894 5 performed perform VBN cord-005453-4057qib7 4894 6 in in IN cord-005453-4057qib7 4894 7 this this DT cord-005453-4057qib7 4894 8 group group NN cord-005453-4057qib7 4894 9 of of IN cord-005453-4057qib7 4894 10 patients patient NNS cord-005453-4057qib7 4894 11 . . . cord-005453-4057qib7 4895 1 Mortality mortality NN cord-005453-4057qib7 4895 2 was be VBD cord-005453-4057qib7 4895 3 0 0 CD cord-005453-4057qib7 4895 4 % % NN cord-005453-4057qib7 4895 5 at at IN cord-005453-4057qib7 4895 6 100 100 CD cord-005453-4057qib7 4895 7 days day NNS cord-005453-4057qib7 4895 8 . . . cord-005453-4057qib7 4896 1 All all DT cord-005453-4057qib7 4896 2 patients patient NNS cord-005453-4057qib7 4896 3 underwent undergo VBD cord-005453-4057qib7 4896 4 successful successful JJ cord-005453-4057qib7 4896 5 ambulatory ambulatory JJ cord-005453-4057qib7 4896 6 mobilization mobilization NN cord-005453-4057qib7 4896 7 . . . cord-005453-4057qib7 4897 1 All all DT cord-005453-4057qib7 4897 2 patients patient NNS cord-005453-4057qib7 4897 3 received receive VBD cord-005453-4057qib7 4897 4 Mephalan Mephalan NNP cord-005453-4057qib7 4897 5 conditioning conditioning NN cord-005453-4057qib7 4897 6 with with IN cord-005453-4057qib7 4897 7 single single JJ cord-005453-4057qib7 4897 8 infusion infusion NN cord-005453-4057qib7 4897 9 with with IN cord-005453-4057qib7 4897 10 median median JJ cord-005453-4057qib7 4897 11 dose dose NN cord-005453-4057qib7 4897 12 of of IN cord-005453-4057qib7 4897 13 200mg 200mg NNP cord-005453-4057qib7 4897 14 / / SYM cord-005453-4057qib7 4897 15 m2 m2 NNP cord-005453-4057qib7 4897 16 ( ( -LRB- cord-005453-4057qib7 4897 17 MIN MIN NNP cord-005453-4057qib7 4897 18 140 140 CD cord-005453-4057qib7 4897 19 , , , cord-005453-4057qib7 4897 20 MAX MAX NNP cord-005453-4057qib7 4897 21 200 200 CD cord-005453-4057qib7 4897 22 ) ) -RRB- cord-005453-4057qib7 4897 23 . . . cord-005453-4057qib7 4898 1 Mean mean JJ cord-005453-4057qib7 4898 2 engraftment engraftment NN cord-005453-4057qib7 4898 3 was be VBD cord-005453-4057qib7 4898 4 10.5 10.5 CD cord-005453-4057qib7 4898 5 days day NNS cord-005453-4057qib7 4898 6 for for IN cord-005453-4057qib7 4898 7 white white JJ cord-005453-4057qib7 4898 8 blood blood NN cord-005453-4057qib7 4898 9 cells cell NNS cord-005453-4057qib7 4898 10 and and CC cord-005453-4057qib7 4898 11 12.7 12.7 CD cord-005453-4057qib7 4898 12 days day NNS cord-005453-4057qib7 4898 13 for for IN cord-005453-4057qib7 4898 14 PLT PLT NNP cord-005453-4057qib7 4898 15 over over IN cord-005453-4057qib7 4898 16 20 20 CD cord-005453-4057qib7 4898 17 G G NNP cord-005453-4057qib7 4898 18 / / SYM cord-005453-4057qib7 4898 19 L. L. NNP cord-005453-4057qib7 4899 1 The the DT cord-005453-4057qib7 4899 2 rate rate NN cord-005453-4057qib7 4899 3 of of IN cord-005453-4057qib7 4899 4 complications complication NNS cord-005453-4057qib7 4899 5 was be VBD cord-005453-4057qib7 4899 6 low low JJ cord-005453-4057qib7 4899 7 with with IN cord-005453-4057qib7 4899 8 7 7 CD cord-005453-4057qib7 4899 9 cases case NNS cord-005453-4057qib7 4899 10 of of IN cord-005453-4057qib7 4899 11 neutropenic neutropenic RB cord-005453-4057qib7 4899 12 fewer few JJR cord-005453-4057qib7 4899 13 , , , cord-005453-4057qib7 4899 14 1 1 CD cord-005453-4057qib7 4899 15 single single JJ cord-005453-4057qib7 4899 16 bacterial bacterial JJ cord-005453-4057qib7 4899 17 culture culture NN cord-005453-4057qib7 4899 18 with with IN cord-005453-4057qib7 4899 19 Staphylococcus Staphylococcus NNP cord-005453-4057qib7 4899 20 Epidermidis Epidermidis NNP cord-005453-4057qib7 4899 21 without without IN cord-005453-4057qib7 4899 22 clinical clinical JJ cord-005453-4057qib7 4899 23 signs sign NNS cord-005453-4057qib7 4899 24 of of IN cord-005453-4057qib7 4899 25 infection infection NN cord-005453-4057qib7 4899 26 , , , cord-005453-4057qib7 4899 27 median median JJ cord-005453-4057qib7 4899 28 mucositis mucositis JJ cord-005453-4057qib7 4899 29 grade grade NN cord-005453-4057qib7 4899 30 of of IN cord-005453-4057qib7 4899 31 0.4 0.4 CD cord-005453-4057qib7 4899 32 and and CC cord-005453-4057qib7 4899 33 without without IN cord-005453-4057qib7 4899 34 patients patient NNS cord-005453-4057qib7 4899 35 on on IN cord-005453-4057qib7 4899 36 parenteral parenteral JJ cord-005453-4057qib7 4899 37 nutrition nutrition NN cord-005453-4057qib7 4899 38 . . . cord-005453-4057qib7 4900 1 The the DT cord-005453-4057qib7 4900 2 median median JJ cord-005453-4057qib7 4900 3 time time NN cord-005453-4057qib7 4900 4 of of IN cord-005453-4057qib7 4900 5 hospitalization hospitalization NN cord-005453-4057qib7 4900 6 was be VBD cord-005453-4057qib7 4900 7 19 19 CD cord-005453-4057qib7 4900 8 days day NNS cord-005453-4057qib7 4900 9 ( ( -LRB- cord-005453-4057qib7 4900 10 MIN MIN NNP cord-005453-4057qib7 4900 11 14 14 CD cord-005453-4057qib7 4900 12 , , , cord-005453-4057qib7 4900 13 MAX MAX NNP cord-005453-4057qib7 4900 14 29 29 CD cord-005453-4057qib7 4900 15 ) ) -RRB- cord-005453-4057qib7 4900 16 . . . cord-005453-4057qib7 4901 1 Conclusions conclusion NNS cord-005453-4057qib7 4901 2 : : : cord-005453-4057qib7 4902 1 We -PRON- PRP cord-005453-4057qib7 4902 2 present present VBP cord-005453-4057qib7 4902 3 here here RB cord-005453-4057qib7 4902 4 novel novel JJ cord-005453-4057qib7 4902 5 protocol protocol NN cord-005453-4057qib7 4902 6 of of IN cord-005453-4057qib7 4902 7 transplantation transplantation NN cord-005453-4057qib7 4902 8 combining combine VBG cord-005453-4057qib7 4902 9 chemomobilization chemomobilization NN cord-005453-4057qib7 4902 10 and and CC cord-005453-4057qib7 4902 11 AHSCT AHSCT NNP cord-005453-4057qib7 4902 12 with with IN cord-005453-4057qib7 4902 13 fresh fresh JJ cord-005453-4057qib7 4902 14 cells cell NNS cord-005453-4057qib7 4902 15 with with IN cord-005453-4057qib7 4902 16 excellent excellent JJ cord-005453-4057qib7 4902 17 safety safety NN cord-005453-4057qib7 4902 18 profile profile NN cord-005453-4057qib7 4902 19 among among IN cord-005453-4057qib7 4902 20 most most RBS cord-005453-4057qib7 4902 21 severely severely RB cord-005453-4057qib7 4902 22 ill ill JJ cord-005453-4057qib7 4902 23 patients patient NNS cord-005453-4057qib7 4902 24 allowing allow VBG cord-005453-4057qib7 4902 25 for for IN cord-005453-4057qib7 4902 26 safe safe JJ cord-005453-4057qib7 4902 27 and and CC cord-005453-4057qib7 4902 28 efficient efficient JJ cord-005453-4057qib7 4902 29 transplants transplant NNS cord-005453-4057qib7 4902 30 . . . cord-005453-4057qib7 4903 1 With with IN cord-005453-4057qib7 4903 2 this this DT cord-005453-4057qib7 4903 3 protocol protocol NN cord-005453-4057qib7 4903 4 we -PRON- PRP cord-005453-4057qib7 4903 5 were be VBD cord-005453-4057qib7 4903 6 able able JJ cord-005453-4057qib7 4903 7 to to TO cord-005453-4057qib7 4903 8 overcome overcome VB cord-005453-4057qib7 4903 9 multiple multiple JJ cord-005453-4057qib7 4903 10 risk risk NN cord-005453-4057qib7 4903 11 factors factor NNS cord-005453-4057qib7 4903 12 and and CC cord-005453-4057qib7 4903 13 perform perform VB cord-005453-4057qib7 4903 14 full full JJ cord-005453-4057qib7 4903 15 intensity intensity NN cord-005453-4057qib7 4903 16 transplantation transplantation NN cord-005453-4057qib7 4903 17 in in IN cord-005453-4057qib7 4903 18 very very RB cord-005453-4057qib7 4903 19 fragile fragile JJ cord-005453-4057qib7 4903 20 patients patient NNS cord-005453-4057qib7 4903 21 . . . cord-005453-4057qib7 4904 1 Disclosure disclosure NN cord-005453-4057qib7 4904 2 : : : cord-005453-4057qib7 4904 3 Nothing nothing NN cord-005453-4057qib7 4904 4 to to TO cord-005453-4057qib7 4904 5 declare declare VB cord-005453-4057qib7 4904 6 Single single JJ cord-005453-4057qib7 4904 7 umbilical umbilical JJ cord-005453-4057qib7 4904 8 cord cord NN cord-005453-4057qib7 4904 9 blood blood NN cord-005453-4057qib7 4904 10 transplantation transplantation NN cord-005453-4057qib7 4904 11 provides provide VBZ cord-005453-4057qib7 4904 12 durable durable JJ cord-005453-4057qib7 4904 13 disease disease NN cord-005453-4057qib7 4904 14 remission remission NN cord-005453-4057qib7 4904 15 of of IN cord-005453-4057qib7 4904 16 advanced advanced JJ cord-005453-4057qib7 4904 17 hematological hematological JJ cord-005453-4057qib7 4904 18 malignancies malignancy NNS cord-005453-4057qib7 4904 19 in in IN cord-005453-4057qib7 4904 20 elderly elderly JJ cord-005453-4057qib7 4904 21 patients patient NNS cord-005453-4057qib7 4905 1 Background background NN cord-005453-4057qib7 4905 2 : : : cord-005453-4057qib7 4906 1 Although although IN cord-005453-4057qib7 4906 2 allogeneic allogeneic IN cord-005453-4057qib7 4906 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 4906 4 stem stem NN cord-005453-4057qib7 4906 5 cell cell NN cord-005453-4057qib7 4906 6 transplantation transplantation NN cord-005453-4057qib7 4906 7 ( ( -LRB- cord-005453-4057qib7 4906 8 allo allo NNP cord-005453-4057qib7 4906 9 HSCT HSCT NNP cord-005453-4057qib7 4906 10 ) ) -RRB- cord-005453-4057qib7 4906 11 is be VBZ cord-005453-4057qib7 4906 12 potentially potentially RB cord-005453-4057qib7 4906 13 curative curative JJ cord-005453-4057qib7 4906 14 therapy therapy NN cord-005453-4057qib7 4906 15 in in IN cord-005453-4057qib7 4906 16 a a DT cord-005453-4057qib7 4906 17 variety variety NN cord-005453-4057qib7 4906 18 of of IN cord-005453-4057qib7 4906 19 hematological hematological JJ cord-005453-4057qib7 4906 20 malignancies malignancy NNS cord-005453-4057qib7 4906 21 , , , cord-005453-4057qib7 4906 22 little little JJ cord-005453-4057qib7 4906 23 has have VBZ cord-005453-4057qib7 4906 24 been be VBN cord-005453-4057qib7 4906 25 reported report VBN cord-005453-4057qib7 4906 26 of of IN cord-005453-4057qib7 4906 27 the the DT cord-005453-4057qib7 4906 28 outcome outcome NN cord-005453-4057qib7 4906 29 for for IN cord-005453-4057qib7 4906 30 elderly elderly JJ cord-005453-4057qib7 4906 31 patients patient NNS cord-005453-4057qib7 4906 32 who who WP cord-005453-4057qib7 4906 33 are be VBP cord-005453-4057qib7 4906 34 not not RB cord-005453-4057qib7 4906 35 in in IN cord-005453-4057qib7 4906 36 remission remission NN cord-005453-4057qib7 4906 37 at at IN cord-005453-4057qib7 4906 38 transplantation transplantation NN cord-005453-4057qib7 4906 39 . . . cord-005453-4057qib7 4907 1 But but CC cord-005453-4057qib7 4907 2 it -PRON- PRP cord-005453-4057qib7 4907 3 has have VBZ cord-005453-4057qib7 4907 4 been be VBN cord-005453-4057qib7 4907 5 pointed point VBN cord-005453-4057qib7 4907 6 out out RP cord-005453-4057qib7 4907 7 that that IN cord-005453-4057qib7 4907 8 recipient recipient NN cord-005453-4057qib7 4907 9 age age NN cord-005453-4057qib7 4907 10 alone alone RB cord-005453-4057qib7 4907 11 can can MD cord-005453-4057qib7 4907 12 not not RB cord-005453-4057qib7 4907 13 be be VB cord-005453-4057qib7 4907 14 regarded regard VBN cord-005453-4057qib7 4907 15 as as IN cord-005453-4057qib7 4907 16 contraindication contraindication NN cord-005453-4057qib7 4907 17 for for IN cord-005453-4057qib7 4907 18 allo allo NNP cord-005453-4057qib7 4907 19 HSCT HSCT NNP cord-005453-4057qib7 4907 20 in in IN cord-005453-4057qib7 4907 21 the the DT cord-005453-4057qib7 4907 22 literature literature NN cord-005453-4057qib7 4907 23 recently recently RB cord-005453-4057qib7 4907 24 , , , cord-005453-4057qib7 4907 25 supported support VBN cord-005453-4057qib7 4907 26 by by IN cord-005453-4057qib7 4907 27 suitable suitable JJ cord-005453-4057qib7 4907 28 donor donor NN cord-005453-4057qib7 4907 29 , , , cord-005453-4057qib7 4907 30 conditioning conditioning NN cord-005453-4057qib7 4907 31 regimens regimen NNS cord-005453-4057qib7 4907 32 and and CC cord-005453-4057qib7 4907 33 appropriate appropriate JJ cord-005453-4057qib7 4907 34 management management NN cord-005453-4057qib7 4907 35 of of IN cord-005453-4057qib7 4907 36 complications complication NNS cord-005453-4057qib7 4907 37 . . . cord-005453-4057qib7 4908 1 We -PRON- PRP cord-005453-4057qib7 4908 2 conducted conduct VBD cord-005453-4057qib7 4908 3 a a DT cord-005453-4057qib7 4908 4 retrospective retrospective JJ cord-005453-4057qib7 4908 5 study study NN cord-005453-4057qib7 4908 6 of of IN cord-005453-4057qib7 4908 7 elderly elderly JJ cord-005453-4057qib7 4908 8 patients patient NNS cord-005453-4057qib7 4908 9 who who WP cord-005453-4057qib7 4908 10 had have VBD cord-005453-4057qib7 4908 11 advanced advanced JJ cord-005453-4057qib7 4908 12 hematologic hematologic JJ cord-005453-4057qib7 4908 13 malignancies malignancy NNS cord-005453-4057qib7 4908 14 to to TO cord-005453-4057qib7 4908 15 elucidate elucidate VB cord-005453-4057qib7 4908 16 the the DT cord-005453-4057qib7 4908 17 outcome outcome NN cord-005453-4057qib7 4908 18 of of IN cord-005453-4057qib7 4908 19 single single JJ cord-005453-4057qib7 4908 20 umbilical umbilical JJ cord-005453-4057qib7 4908 21 cord cord NN cord-005453-4057qib7 4908 22 blood blood NN cord-005453-4057qib7 4908 23 transplantation transplantation NN cord-005453-4057qib7 4908 24 ( ( -LRB- cord-005453-4057qib7 4908 25 sUCBT sucbt NN cord-005453-4057qib7 4908 26 ) ) -RRB- cord-005453-4057qib7 4908 27 in in IN cord-005453-4057qib7 4908 28 Toranomon Toranomon NNP cord-005453-4057qib7 4908 29 Hospital Hospital NNP cord-005453-4057qib7 4908 30 Kajigaya Kajigaya NNP cord-005453-4057qib7 4908 31 , , , cord-005453-4057qib7 4908 32 Japan Japan NNP cord-005453-4057qib7 4908 33 . . . cord-005453-4057qib7 4909 1 Methods method NNS cord-005453-4057qib7 4910 1 : : : cord-005453-4057qib7 4910 2 We -PRON- PRP cord-005453-4057qib7 4910 3 retrospectively retrospectively RB cord-005453-4057qib7 4910 4 investigated investigate VBD cord-005453-4057qib7 4910 5 the the DT cord-005453-4057qib7 4910 6 outcomes outcome NNS cord-005453-4057qib7 4910 7 of of IN cord-005453-4057qib7 4910 8 19 19 CD cord-005453-4057qib7 4910 9 patients patient NNS cord-005453-4057qib7 4910 10 aged age VBN cord-005453-4057qib7 4910 11 over over IN cord-005453-4057qib7 4910 12 65 65 CD cord-005453-4057qib7 4910 13 who who WP cord-005453-4057qib7 4910 14 underwent undergo VBD cord-005453-4057qib7 4910 15 their -PRON- PRP$ cord-005453-4057qib7 4910 16 first first JJ cord-005453-4057qib7 4910 17 UCBT UCBT NNP cord-005453-4057qib7 4910 18 from from IN cord-005453-4057qib7 4910 19 June June NNP cord-005453-4057qib7 4910 20 2013 2013 CD cord-005453-4057qib7 4910 21 to to IN cord-005453-4057qib7 4910 22 December December NNP cord-005453-4057qib7 4910 23 2017 2017 CD cord-005453-4057qib7 4910 24 in in IN cord-005453-4057qib7 4910 25 our -PRON- PRP$ cord-005453-4057qib7 4910 26 medical medical JJ cord-005453-4057qib7 4910 27 center center NN cord-005453-4057qib7 4910 28 . . . cord-005453-4057qib7 4911 1 Results result NNS cord-005453-4057qib7 4911 2 : : : cord-005453-4057qib7 4912 1 Diseases disease NNS cord-005453-4057qib7 4912 2 included include VBD cord-005453-4057qib7 4912 3 acute acute JJ cord-005453-4057qib7 4912 4 myelogenous myelogenous NN cord-005453-4057qib7 4912 5 leukemia leukemia NN cord-005453-4057qib7 4912 6 ( ( -LRB- cord-005453-4057qib7 4912 7 n=12 n=12 NNP cord-005453-4057qib7 4912 8 ) ) -RRB- cord-005453-4057qib7 4912 9 , , , cord-005453-4057qib7 4912 10 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 4912 11 syndrome syndrome NN cord-005453-4057qib7 4912 12 ( ( -LRB- cord-005453-4057qib7 4912 13 n=3 n=3 NN cord-005453-4057qib7 4912 14 ) ) -RRB- cord-005453-4057qib7 4912 15 , , , cord-005453-4057qib7 4912 16 adult adult NN cord-005453-4057qib7 4912 17 T t NN cord-005453-4057qib7 4912 18 - - HYPH cord-005453-4057qib7 4912 19 cell cell NN cord-005453-4057qib7 4912 20 leukemia leukemia NN cord-005453-4057qib7 4912 21 / / SYM cord-005453-4057qib7 4912 22 lymphoma lymphoma NN cord-005453-4057qib7 4912 23 ( ( -LRB- cord-005453-4057qib7 4912 24 n=2 n=2 NNP cord-005453-4057qib7 4912 25 ) ) -RRB- cord-005453-4057qib7 4912 26 , , , cord-005453-4057qib7 4912 27 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 4912 28 ( ( -LRB- cord-005453-4057qib7 4912 29 n=1 n=1 NNP cord-005453-4057qib7 4912 30 ) ) -RRB- cord-005453-4057qib7 4912 31 and and CC cord-005453-4057qib7 4912 32 chronic chronic JJ cord-005453-4057qib7 4912 33 lymphocytic lymphocytic JJ cord-005453-4057qib7 4912 34 leukemia leukemia NN cord-005453-4057qib7 4912 35 ( ( -LRB- cord-005453-4057qib7 4912 36 n=1 n=1 NN cord-005453-4057qib7 4912 37 ) ) -RRB- cord-005453-4057qib7 4912 38 . . . cord-005453-4057qib7 4913 1 The the DT cord-005453-4057qib7 4913 2 median median JJ cord-005453-4057qib7 4913 3 age age NN cord-005453-4057qib7 4913 4 at at IN cord-005453-4057qib7 4913 5 transplantation transplantation NN cord-005453-4057qib7 4913 6 was be VBD cord-005453-4057qib7 4913 7 69 69 CD cord-005453-4057qib7 4913 8 years year NNS cord-005453-4057qib7 4914 1 ( ( -LRB- cord-005453-4057qib7 4914 2 range range NN cord-005453-4057qib7 4914 3 , , , cord-005453-4057qib7 4914 4 65 65 CD cord-005453-4057qib7 4914 5 - - SYM cord-005453-4057qib7 4914 6 75 75 CD cord-005453-4057qib7 4914 7 ) ) -RRB- cord-005453-4057qib7 4914 8 and and CC cord-005453-4057qib7 4914 9 follow follow NN cord-005453-4057qib7 4914 10 - - HYPH cord-005453-4057qib7 4914 11 up up NN cord-005453-4057qib7 4914 12 for for IN cord-005453-4057qib7 4914 13 survivor survivor NN cord-005453-4057qib7 4914 14 post post NN cord-005453-4057qib7 4914 15 transplantation transplantation NN cord-005453-4057qib7 4914 16 was be VBD cord-005453-4057qib7 4914 17 642 642 CD cord-005453-4057qib7 4914 18 day day NN cord-005453-4057qib7 4914 19 ( ( -LRB- cord-005453-4057qib7 4914 20 range range NN cord-005453-4057qib7 4914 21 , , , cord-005453-4057qib7 4914 22 391 391 CD cord-005453-4057qib7 4914 23 - - HYPH cord-005453-4057qib7 4914 24 767 767 NNP cord-005453-4057qib7 4914 25 ) ) -RRB- cord-005453-4057qib7 4914 26 . . . cord-005453-4057qib7 4915 1 All all DT cord-005453-4057qib7 4915 2 patients patient NNS cord-005453-4057qib7 4915 3 were be VBD cord-005453-4057qib7 4915 4 not not RB cord-005453-4057qib7 4915 5 in in IN cord-005453-4057qib7 4915 6 complete complete JJ cord-005453-4057qib7 4915 7 remission remission NN cord-005453-4057qib7 4915 8 ( ( -LRB- cord-005453-4057qib7 4915 9 CR CR NNP cord-005453-4057qib7 4915 10 ) ) -RRB- cord-005453-4057qib7 4915 11 at at IN cord-005453-4057qib7 4915 12 the the DT cord-005453-4057qib7 4915 13 time time NN cord-005453-4057qib7 4915 14 of of IN cord-005453-4057qib7 4915 15 transplantation transplantation NN cord-005453-4057qib7 4915 16 . . . cord-005453-4057qib7 4916 1 Reduced reduced JJ cord-005453-4057qib7 4916 2 intensity intensity NN cord-005453-4057qib7 4916 3 conditioning conditioning NN cord-005453-4057qib7 4916 4 ( ( -LRB- cord-005453-4057qib7 4916 5 RIC RIC NNP cord-005453-4057qib7 4916 6 ) ) -RRB- cord-005453-4057qib7 4916 7 regimens regimen NNS cord-005453-4057qib7 4916 8 were be VBD cord-005453-4057qib7 4916 9 used use VBN cord-005453-4057qib7 4916 10 in in IN cord-005453-4057qib7 4916 11 10 10 CD cord-005453-4057qib7 4916 12 patients patient NNS cord-005453-4057qib7 4916 13 . . . cord-005453-4057qib7 4917 1 All all DT cord-005453-4057qib7 4917 2 patients patient NNS cord-005453-4057qib7 4917 3 received receive VBD cord-005453-4057qib7 4917 4 tacrolimus tacrolimus NNP cord-005453-4057qib7 4917 5 and and CC cord-005453-4057qib7 4917 6 mycophenolate mycophenolate NNP cord-005453-4057qib7 4917 7 mofetil mofetil NNP cord-005453-4057qib7 4917 8 as as IN cord-005453-4057qib7 4917 9 graftversus graftversus NNP cord-005453-4057qib7 4917 10 - - HYPH cord-005453-4057qib7 4917 11 host host NN cord-005453-4057qib7 4917 12 disease disease NN cord-005453-4057qib7 4917 13 ( ( -LRB- cord-005453-4057qib7 4917 14 GVHD GVHD NNP cord-005453-4057qib7 4917 15 ) ) -RRB- cord-005453-4057qib7 4917 16 prophylaxis prophylaxis NN cord-005453-4057qib7 4917 17 . . . cord-005453-4057qib7 4918 1 All all DT cord-005453-4057qib7 4918 2 cases case NNS cord-005453-4057qib7 4918 3 except except IN cord-005453-4057qib7 4918 4 4 4 CD cord-005453-4057qib7 4918 5 early early JJ cord-005453-4057qib7 4918 6 death death NN cord-005453-4057qib7 4918 7 achieved achieve VBD cord-005453-4057qib7 4918 8 neutrophil neutrophil NN cord-005453-4057qib7 4918 9 recovery recovery NN cord-005453-4057qib7 4918 10 at at IN cord-005453-4057qib7 4918 11 median median NN cord-005453-4057qib7 4918 12 18 18 CD cord-005453-4057qib7 4918 13 days day NNS cord-005453-4057qib7 4918 14 ( ( -LRB- cord-005453-4057qib7 4918 15 range range NN cord-005453-4057qib7 4918 16 , , , cord-005453-4057qib7 4918 17 13 13 CD cord-005453-4057qib7 4918 18 - - SYM cord-005453-4057qib7 4918 19 28 28 CD cord-005453-4057qib7 4918 20 ) ) -RRB- cord-005453-4057qib7 4918 21 . . . cord-005453-4057qib7 4919 1 At at IN cord-005453-4057qib7 4919 2 1 1 CD cord-005453-4057qib7 4919 3 year year NN cord-005453-4057qib7 4919 4 , , , cord-005453-4057qib7 4919 5 overall overall JJ cord-005453-4057qib7 4919 6 survival survival NN cord-005453-4057qib7 4919 7 ( ( -LRB- cord-005453-4057qib7 4919 8 OS os NN cord-005453-4057qib7 4919 9 ) ) -RRB- cord-005453-4057qib7 4919 10 rate rate NN cord-005453-4057qib7 4919 11 and and CC cord-005453-4057qib7 4919 12 disease disease NN cord-005453-4057qib7 4919 13 free free JJ cord-005453-4057qib7 4919 14 survival survival NN cord-005453-4057qib7 4919 15 ( ( -LRB- cord-005453-4057qib7 4919 16 DFS DFS NNP cord-005453-4057qib7 4919 17 ) ) -RRB- cord-005453-4057qib7 4919 18 were be VBD cord-005453-4057qib7 4919 19 31,6 31,6 CD cord-005453-4057qib7 4919 20 % % NN cord-005453-4057qib7 4919 21 ( ( -LRB- cord-005453-4057qib7 4919 22 95 95 CD cord-005453-4057qib7 4919 23 % % NN cord-005453-4057qib7 4919 24 confidence confidence NN cord-005453-4057qib7 4919 25 interval interval NN cord-005453-4057qib7 4919 26 ( ( -LRB- cord-005453-4057qib7 4919 27 CI CI NNP cord-005453-4057qib7 4919 28 ) ) -RRB- cord-005453-4057qib7 4919 29 , , , cord-005453-4057qib7 4919 30 12.9 12.9 CD cord-005453-4057qib7 4919 31 - - SYM cord-005453-4057qib7 4919 32 52.2 52.2 CD cord-005453-4057qib7 4919 33 ) ) -RRB- cord-005453-4057qib7 4919 34 . . . cord-005453-4057qib7 4920 1 We -PRON- PRP cord-005453-4057qib7 4920 2 performed perform VBD cord-005453-4057qib7 4920 3 univariate univariate JJ cord-005453-4057qib7 4920 4 analysis analysis NN cord-005453-4057qib7 4920 5 to to TO cord-005453-4057qib7 4920 6 identify identify VB cord-005453-4057qib7 4920 7 the the DT cord-005453-4057qib7 4920 8 factor factor NN cord-005453-4057qib7 4920 9 that that WDT cord-005453-4057qib7 4920 10 influenced influence VBD cord-005453-4057qib7 4920 11 OS OS NNP cord-005453-4057qib7 4920 12 at at IN cord-005453-4057qib7 4920 13 1 1 CD cord-005453-4057qib7 4920 14 year year NN cord-005453-4057qib7 4920 15 , , , cord-005453-4057qib7 4920 16 but but CC cord-005453-4057qib7 4920 17 no no DT cord-005453-4057qib7 4920 18 statistical statistical JJ cord-005453-4057qib7 4920 19 significance significance NN cord-005453-4057qib7 4920 20 was be VBD cord-005453-4057qib7 4920 21 demonstrated demonstrate VBN cord-005453-4057qib7 4920 22 at at IN cord-005453-4057qib7 4920 23 the the DT cord-005453-4057qib7 4920 24 age age NN cord-005453-4057qib7 4920 25 of of IN cord-005453-4057qib7 4920 26 transplantation transplantation NN cord-005453-4057qib7 4920 27 ( ( -LRB- cord-005453-4057qib7 4920 28 Aged aged JJ cord-005453-4057qib7 4920 29 65 65 CD cord-005453-4057qib7 4920 30 to to TO cord-005453-4057qib7 4920 31 69 69 CD cord-005453-4057qib7 4920 32 vs. vs. NN cord-005453-4057qib7 4920 33 ≧70 ≧70 CD cord-005453-4057qib7 4920 34 , , , cord-005453-4057qib7 4920 35 33.3 33.3 CD cord-005453-4057qib7 4920 36 % % NN cord-005453-4057qib7 4920 37 ( ( -LRB- cord-005453-4057qib7 4920 38 95 95 CD cord-005453-4057qib7 4920 39 % % NN cord-005453-4057qib7 4920 40 CI CI NNP cord-005453-4057qib7 4920 41 , , , cord-005453-4057qib7 4920 42 10.3 10.3 CD cord-005453-4057qib7 4920 43 - - HYPH cord-005453-4057qib7 4920 44 58.8 58.8 CD cord-005453-4057qib7 4920 45 ) ) -RRB- cord-005453-4057qib7 4920 46 vs. vs. IN cord-005453-4057qib7 4920 47 42.9 42.9 CD cord-005453-4057qib7 4920 48 % % NN cord-005453-4057qib7 4920 49 ( ( -LRB- cord-005453-4057qib7 4920 50 95 95 CD cord-005453-4057qib7 4920 51 % % NN cord-005453-4057qib7 4920 52 CI CI NNP cord-005453-4057qib7 4920 53 , , , cord-005453-4057qib7 4920 54 9.8 9.8 CD cord-005453-4057qib7 4920 55 - - HYPH cord-005453-4057qib7 4920 56 73.4 73.4 CD cord-005453-4057qib7 4920 57 ) ) -RRB- cord-005453-4057qib7 4920 58 , , , cord-005453-4057qib7 4920 59 p=0.68 p=0.68 NN cord-005453-4057qib7 4920 60 ) ) -RRB- cord-005453-4057qib7 4920 61 . . . cord-005453-4057qib7 4921 1 The the DT cord-005453-4057qib7 4921 2 cumulative cumulative JJ cord-005453-4057qib7 4921 3 incidence incidence NN cord-005453-4057qib7 4921 4 of of IN cord-005453-4057qib7 4921 5 non non JJ cord-005453-4057qib7 4921 6 - - JJ cord-005453-4057qib7 4921 7 relapse relapse JJ cord-005453-4057qib7 4921 8 mortality mortality NN cord-005453-4057qib7 4921 9 ( ( -LRB- cord-005453-4057qib7 4921 10 NRM NRM NNP cord-005453-4057qib7 4921 11 ) ) -RRB- cord-005453-4057qib7 4921 12 at at IN cord-005453-4057qib7 4921 13 100 100 CD cord-005453-4057qib7 4921 14 days day NNS cord-005453-4057qib7 4921 15 was be VBD cord-005453-4057qib7 4921 16 47.4 47.4 CD cord-005453-4057qib7 4921 17 % % NN cord-005453-4057qib7 4921 18 ( ( -LRB- cord-005453-4057qib7 4921 19 95 95 CD cord-005453-4057qib7 4921 20 % % NN cord-005453-4057qib7 4921 21 CI CI NNP cord-005453-4057qib7 4921 22 , , , cord-005453-4057qib7 4921 23 23.6 23.6 CD cord-005453-4057qib7 4921 24 - - HYPH cord-005453-4057qib7 4921 25 67.9 67.9 CD cord-005453-4057qib7 4921 26 % % NN cord-005453-4057qib7 4921 27 ) ) -RRB- cord-005453-4057qib7 4921 28 and and CC cord-005453-4057qib7 4921 29 relapse relapse VB cord-005453-4057qib7 4921 30 at at IN cord-005453-4057qib7 4921 31 1 1 CD cord-005453-4057qib7 4921 32 year year NN cord-005453-4057qib7 4921 33 was be VBD cord-005453-4057qib7 4921 34 9.1 9.1 CD cord-005453-4057qib7 4921 35 % % NN cord-005453-4057qib7 4921 36 ( ( -LRB- cord-005453-4057qib7 4921 37 95 95 CD cord-005453-4057qib7 4921 38 % % NN cord-005453-4057qib7 4921 39 CI CI NNP cord-005453-4057qib7 4921 40 , , , cord-005453-4057qib7 4921 41 0.0 0.0 CD cord-005453-4057qib7 4921 42 - - HYPH cord-005453-4057qib7 4921 43 24.6 24.6 CD cord-005453-4057qib7 4921 44 % % NN cord-005453-4057qib7 4921 45 ) ) -RRB- cord-005453-4057qib7 4921 46 . . . cord-005453-4057qib7 4922 1 Only only RB cord-005453-4057qib7 4922 2 two two CD cord-005453-4057qib7 4922 3 patients patient NNS cord-005453-4057qib7 4922 4 developed develop VBD cord-005453-4057qib7 4922 5 acute acute JJ cord-005453-4057qib7 4922 6 GVHD(II GVHD(II NNP cord-005453-4057qib7 4922 7 - - HYPH cord-005453-4057qib7 4922 8 IV IV NNP cord-005453-4057qib7 4922 9 ) ) -RRB- cord-005453-4057qib7 4922 10 and and CC cord-005453-4057qib7 4922 11 one one CD cord-005453-4057qib7 4922 12 developed develop VBD cord-005453-4057qib7 4922 13 severe severe JJ cord-005453-4057qib7 4922 14 GVHD GVHD NNP cord-005453-4057qib7 4922 15 at at IN cord-005453-4057qib7 4922 16 49 49 CD cord-005453-4057qib7 4922 17 days day NNS cord-005453-4057qib7 4922 18 after after IN cord-005453-4057qib7 4922 19 transplantation transplantation NN cord-005453-4057qib7 4922 20 . . . cord-005453-4057qib7 4923 1 The the DT cord-005453-4057qib7 4923 2 main main JJ cord-005453-4057qib7 4923 3 causes cause NNS cord-005453-4057qib7 4923 4 of of IN cord-005453-4057qib7 4923 5 death death NN cord-005453-4057qib7 4923 6 was be VBD cord-005453-4057qib7 4923 7 infection infection NN cord-005453-4057qib7 4923 8 ( ( -LRB- cord-005453-4057qib7 4923 9 n=10 n=10 NNP cord-005453-4057qib7 4923 10 ) ) -RRB- cord-005453-4057qib7 4923 11 , , , cord-005453-4057qib7 4923 12 including include VBG cord-005453-4057qib7 4923 13 sepsis sepsis NN cord-005453-4057qib7 4923 14 ( ( -LRB- cord-005453-4057qib7 4923 15 n=8 n=8 NN cord-005453-4057qib7 4923 16 ) ) -RRB- cord-005453-4057qib7 4923 17 and and CC cord-005453-4057qib7 4923 18 viral viral JJ cord-005453-4057qib7 4923 19 encephalitis encephalitis NN cord-005453-4057qib7 4923 20 ( ( -LRB- cord-005453-4057qib7 4923 21 n=2 n=2 NNS cord-005453-4057qib7 4923 22 ) ) -RRB- cord-005453-4057qib7 4923 23 , , , cord-005453-4057qib7 4923 24 followed follow VBN cord-005453-4057qib7 4923 25 by by IN cord-005453-4057qib7 4923 26 idiopathic idiopathic JJ cord-005453-4057qib7 4923 27 pneumonia pneumonia NN cord-005453-4057qib7 4923 28 syndrome syndrome NN cord-005453-4057qib7 4923 29 ( ( -LRB- cord-005453-4057qib7 4923 30 n=2 n=2 NNP cord-005453-4057qib7 4923 31 ) ) -RRB- cord-005453-4057qib7 4923 32 and and CC cord-005453-4057qib7 4923 33 thrombotic thrombotic JJ cord-005453-4057qib7 4923 34 microangiopathy microangiopathy NNP cord-005453-4057qib7 4923 35 ( ( -LRB- cord-005453-4057qib7 4923 36 n=1 n=1 UH cord-005453-4057qib7 4923 37 ) ) -RRB- cord-005453-4057qib7 4923 38 during during IN cord-005453-4057qib7 4923 39 the the DT cord-005453-4057qib7 4923 40 early early JJ cord-005453-4057qib7 4923 41 phase phase NN cord-005453-4057qib7 4923 42 of of IN cord-005453-4057qib7 4923 43 transplantation transplantation NN cord-005453-4057qib7 4923 44 . . . cord-005453-4057qib7 4924 1 In in IN cord-005453-4057qib7 4924 2 contrast contrast NN cord-005453-4057qib7 4924 3 , , , cord-005453-4057qib7 4924 4 no no DT cord-005453-4057qib7 4924 5 patients patient NNS cord-005453-4057qib7 4924 6 died die VBD cord-005453-4057qib7 4924 7 of of IN cord-005453-4057qib7 4924 8 recurrence recurrence NN cord-005453-4057qib7 4924 9 . . . cord-005453-4057qib7 4925 1 Conclusions conclusion NNS cord-005453-4057qib7 4925 2 : : : cord-005453-4057qib7 4926 1 Although although IN cord-005453-4057qib7 4926 2 our -PRON- PRP$ cord-005453-4057qib7 4926 3 report report NN cord-005453-4057qib7 4926 4 consisted consist VBD cord-005453-4057qib7 4926 5 relapsed/ relapsed/ NNP cord-005453-4057qib7 4926 6 refractory refractory JJ cord-005453-4057qib7 4926 7 disease disease NN cord-005453-4057qib7 4926 8 of of IN cord-005453-4057qib7 4926 9 elderly elderly JJ cord-005453-4057qib7 4926 10 patients patient NNS cord-005453-4057qib7 4926 11 at at IN cord-005453-4057qib7 4926 12 the the DT cord-005453-4057qib7 4926 13 time time NN cord-005453-4057qib7 4926 14 of of IN cord-005453-4057qib7 4926 15 sUCBT sUCBT NNS cord-005453-4057qib7 4926 16 , , , cord-005453-4057qib7 4926 17 durable durable JJ cord-005453-4057qib7 4926 18 remission remission NN cord-005453-4057qib7 4926 19 and and CC cord-005453-4057qib7 4926 20 lower low JJR cord-005453-4057qib7 4926 21 incidence incidence NN cord-005453-4057qib7 4926 22 of of IN cord-005453-4057qib7 4926 23 GVHD GVHD NNP cord-005453-4057qib7 4926 24 could could MD cord-005453-4057qib7 4926 25 be be VB cord-005453-4057qib7 4926 26 noteworthy noteworthy JJ cord-005453-4057qib7 4926 27 compared compare VBN cord-005453-4057qib7 4926 28 with with IN cord-005453-4057qib7 4926 29 previous previous JJ cord-005453-4057qib7 4926 30 reports report NNS cord-005453-4057qib7 4926 31 . . . cord-005453-4057qib7 4927 1 Further further JJ cord-005453-4057qib7 4927 2 strategies strategy NNS cord-005453-4057qib7 4927 3 to to TO cord-005453-4057qib7 4927 4 reduce reduce VB cord-005453-4057qib7 4927 5 the the DT cord-005453-4057qib7 4927 6 rate rate NN cord-005453-4057qib7 4927 7 of of IN cord-005453-4057qib7 4927 8 NRM NRM NNP cord-005453-4057qib7 4927 9 and and CC cord-005453-4057qib7 4927 10 longer long JJR cord-005453-4057qib7 4927 11 duration duration NN cord-005453-4057qib7 4927 12 of of IN cord-005453-4057qib7 4927 13 follow follow NN cord-005453-4057qib7 4927 14 up up RP cord-005453-4057qib7 4927 15 would would MD cord-005453-4057qib7 4927 16 be be VB cord-005453-4057qib7 4927 17 warranted warrant VBN cord-005453-4057qib7 4927 18 . . . cord-005453-4057qib7 4928 1 Disclosure disclosure NN cord-005453-4057qib7 4928 2 Background Background NNP cord-005453-4057qib7 4928 3 : : : cord-005453-4057qib7 4928 4 Pearson Pearson NNP cord-005453-4057qib7 4928 5 syndrome syndrome NN cord-005453-4057qib7 4928 6 and and CC cord-005453-4057qib7 4928 7 Kearns Kearns NNP cord-005453-4057qib7 4928 8 - - HYPH cord-005453-4057qib7 4928 9 Sayre Sayre NNP cord-005453-4057qib7 4928 10 syndrome syndrome NN cord-005453-4057qib7 4928 11 are be VBP cord-005453-4057qib7 4928 12 metabolic metabolic JJ cord-005453-4057qib7 4928 13 disorders disorder NNS cord-005453-4057qib7 4928 14 caused cause VBN cord-005453-4057qib7 4928 15 by by IN cord-005453-4057qib7 4928 16 a a DT cord-005453-4057qib7 4928 17 de de JJ cord-005453-4057qib7 4928 18 - - JJ cord-005453-4057qib7 4928 19 novo novo JJ cord-005453-4057qib7 4928 20 deletion deletion NN cord-005453-4057qib7 4928 21 in in IN cord-005453-4057qib7 4928 22 the the DT cord-005453-4057qib7 4928 23 mitochondrial mitochondrial JJ cord-005453-4057qib7 4928 24 DNA dna NN cord-005453-4057qib7 4928 25 ( ( -LRB- cord-005453-4057qib7 4928 26 mtDNA mtDNA NNP cord-005453-4057qib7 4928 27 ) ) -RRB- cord-005453-4057qib7 4928 28 . . . cord-005453-4057qib7 4929 1 Allogeneic allogeneic IN cord-005453-4057qib7 4929 2 stem stem VBP cord-005453-4057qib7 4929 3 cell cell NN cord-005453-4057qib7 4929 4 transplantation transplantation NN cord-005453-4057qib7 4929 5 has have VBZ cord-005453-4057qib7 4929 6 shown show VBN cord-005453-4057qib7 4929 7 to to TO cord-005453-4057qib7 4929 8 improve improve VB cord-005453-4057qib7 4929 9 metabolic metabolic JJ cord-005453-4057qib7 4929 10 function function NN cord-005453-4057qib7 4929 11 in in IN cord-005453-4057qib7 4929 12 distal distal JJ cord-005453-4057qib7 4929 13 organs organ NNS cord-005453-4057qib7 4929 14 in in IN cord-005453-4057qib7 4929 15 several several JJ cord-005453-4057qib7 4929 16 metabolic metabolic JJ cord-005453-4057qib7 4929 17 disorders disorder NNS cord-005453-4057qib7 4929 18 , , , cord-005453-4057qib7 4929 19 but but CC cord-005453-4057qib7 4929 20 bears bear VBZ cord-005453-4057qib7 4929 21 significant significant JJ cord-005453-4057qib7 4929 22 morbidity morbidity NN cord-005453-4057qib7 4929 23 and and CC cord-005453-4057qib7 4929 24 mortality mortality NN cord-005453-4057qib7 4929 25 , , , cord-005453-4057qib7 4929 26 especially especially RB cord-005453-4057qib7 4929 27 for for IN cord-005453-4057qib7 4929 28 patients patient NNS cord-005453-4057qib7 4929 29 with with IN cord-005453-4057qib7 4929 30 mitochondrial mitochondrial JJ cord-005453-4057qib7 4929 31 disorders disorder NNS cord-005453-4057qib7 4929 32 . . . cord-005453-4057qib7 4930 1 Novel novel JJ cord-005453-4057qib7 4930 2 gene gene NN cord-005453-4057qib7 4930 3 therapies therapy NNS cord-005453-4057qib7 4930 4 may may MD cord-005453-4057qib7 4930 5 correct correct VB cord-005453-4057qib7 4930 6 diseases disease NNS cord-005453-4057qib7 4930 7 rising rise VBG cord-005453-4057qib7 4930 8 from from IN cord-005453-4057qib7 4930 9 genomic genomic JJ cord-005453-4057qib7 4930 10 DNA dna NN cord-005453-4057qib7 4930 11 mutations mutation NNS cord-005453-4057qib7 4930 12 , , , cord-005453-4057qib7 4930 13 but but CC cord-005453-4057qib7 4930 14 targeting target VBG cord-005453-4057qib7 4930 15 the the DT cord-005453-4057qib7 4930 16 mitochondrial mitochondrial JJ cord-005453-4057qib7 4930 17 DNA dna NN cord-005453-4057qib7 4930 18 is be VBZ cord-005453-4057qib7 4930 19 complex complex JJ cord-005453-4057qib7 4930 20 . . . cord-005453-4057qib7 4931 1 Mitochondria mitochondrion NNS cord-005453-4057qib7 4931 2 are be VBP cord-005453-4057qib7 4931 3 able able JJ cord-005453-4057qib7 4931 4 to to TO cord-005453-4057qib7 4931 5 transfer transfer VB cord-005453-4057qib7 4931 6 into into IN cord-005453-4057qib7 4931 7 cells cell NNS cord-005453-4057qib7 4931 8 and and CC cord-005453-4057qib7 4931 9 between between IN cord-005453-4057qib7 4931 10 cells cell NNS cord-005453-4057qib7 4931 11 , , , cord-005453-4057qib7 4931 12 as as IN cord-005453-4057qib7 4931 13 seen see VBN cord-005453-4057qib7 4931 14 in in IN cord-005453-4057qib7 4931 15 preclinical preclinical JJ cord-005453-4057qib7 4931 16 models model NNS cord-005453-4057qib7 4931 17 of of IN cord-005453-4057qib7 4931 18 mitochondrial mitochondrial JJ cord-005453-4057qib7 4931 19 and and CC cord-005453-4057qib7 4931 20 other other JJ cord-005453-4057qib7 4931 21 metabolic metabolic JJ cord-005453-4057qib7 4931 22 disorders disorder NNS cord-005453-4057qib7 4931 23 . . . cord-005453-4057qib7 4932 1 Here here RB cord-005453-4057qib7 4932 2 , , , cord-005453-4057qib7 4932 3 we -PRON- PRP cord-005453-4057qib7 4932 4 introduce introduce VBP cord-005453-4057qib7 4932 5 a a DT cord-005453-4057qib7 4932 6 novel novel JJ cord-005453-4057qib7 4932 7 concept concept NN cord-005453-4057qib7 4932 8 of of IN cord-005453-4057qib7 4932 9 mitochondrial mitochondrial JJ cord-005453-4057qib7 4932 10 augmentation augmentation NN cord-005453-4057qib7 4932 11 therapy therapy NN cord-005453-4057qib7 4932 12 ( ( -LRB- cord-005453-4057qib7 4932 13 MAT MAT NNP cord-005453-4057qib7 4932 14 ) ) -RRB- cord-005453-4057qib7 4932 15 of of IN cord-005453-4057qib7 4932 16 autologous autologous JJ cord-005453-4057qib7 4932 17 CD34 CD34 NNP cord-005453-4057qib7 4932 18 + + CC cord-005453-4057qib7 4932 19 cells cell NNS cord-005453-4057qib7 4932 20 in in IN cord-005453-4057qib7 4932 21 4 4 CD cord-005453-4057qib7 4932 22 children child NNS cord-005453-4057qib7 4932 23 with with IN cord-005453-4057qib7 4932 24 mitochondrial mitochondrial JJ cord-005453-4057qib7 4932 25 deletion deletion NN cord-005453-4057qib7 4932 26 syndromes syndrome NNS cord-005453-4057qib7 4932 27 . . . cord-005453-4057qib7 4933 1 Methods method NNS cord-005453-4057qib7 4933 2 : : : cord-005453-4057qib7 4933 3 Patients patient NNS cord-005453-4057qib7 4933 4 were be VBD cord-005453-4057qib7 4933 5 treated treat VBN cord-005453-4057qib7 4933 6 under under IN cord-005453-4057qib7 4933 7 a a DT cord-005453-4057qib7 4933 8 compassionateuse compassionateuse NN cord-005453-4057qib7 4933 9 program program NN cord-005453-4057qib7 4933 10 , , , cord-005453-4057qib7 4933 11 approved approve VBN cord-005453-4057qib7 4933 12 by by IN cord-005453-4057qib7 4933 13 the the DT cord-005453-4057qib7 4933 14 Sheba Sheba NNP cord-005453-4057qib7 4933 15 Medical Medical NNP cord-005453-4057qib7 4933 16 Center Center NNP cord-005453-4057qib7 4933 17 IRB IRB NNP cord-005453-4057qib7 4933 18 and and CC cord-005453-4057qib7 4933 19 the the DT cord-005453-4057qib7 4933 20 Israeli israeli JJ cord-005453-4057qib7 4933 21 Ministry Ministry NNP cord-005453-4057qib7 4933 22 of of IN cord-005453-4057qib7 4933 23 Health Health NNP cord-005453-4057qib7 4933 24 . . . cord-005453-4057qib7 4934 1 Briefly briefly RB cord-005453-4057qib7 4934 2 , , , cord-005453-4057qib7 4934 3 mobilization mobilization NN cord-005453-4057qib7 4934 4 was be VBD cord-005453-4057qib7 4934 5 performed perform VBN cord-005453-4057qib7 4934 6 using use VBG cord-005453-4057qib7 4934 7 GCSF GCSF NNP cord-005453-4057qib7 4934 8 alone alone JJ cord-005453-4057qib7 4934 9 ( ( -LRB- cord-005453-4057qib7 4934 10 n=1 n=1 JJ cord-005453-4057qib7 4934 11 ) ) -RRB- cord-005453-4057qib7 4934 12 or or CC cord-005453-4057qib7 4934 13 in in IN cord-005453-4057qib7 4934 14 addition addition NN cord-005453-4057qib7 4934 15 to to IN cord-005453-4057qib7 4934 16 plerixafor plerixafor NN cord-005453-4057qib7 4934 17 ( ( -LRB- cord-005453-4057qib7 4934 18 n=3 n=3 NN cord-005453-4057qib7 4934 19 ) ) -RRB- cord-005453-4057qib7 4934 20 . . . cord-005453-4057qib7 4935 1 CD34 CD34 NNP cord-005453-4057qib7 4935 2 + + CC cord-005453-4057qib7 4935 3 cells cell NNS cord-005453-4057qib7 4935 4 were be VBD cord-005453-4057qib7 4935 5 isolated isolate VBN cord-005453-4057qib7 4935 6 via via IN cord-005453-4057qib7 4935 7 Miltenyi Miltenyi NNP cord-005453-4057qib7 4935 8 CliniMACS CliniMACS NNP cord-005453-4057qib7 4935 9 system system NN cord-005453-4057qib7 4935 10 and and CC cord-005453-4057qib7 4935 11 co co NN cord-005453-4057qib7 4935 12 - - JJ cord-005453-4057qib7 4935 13 cultured cultured JJ cord-005453-4057qib7 4935 14 with with IN cord-005453-4057qib7 4935 15 maternal maternal JJ cord-005453-4057qib7 4935 16 mitochondria mitochondrion NNS cord-005453-4057qib7 4935 17 , , , cord-005453-4057qib7 4935 18 drawn draw VBN cord-005453-4057qib7 4935 19 from from IN cord-005453-4057qib7 4935 20 peripheral peripheral JJ cord-005453-4057qib7 4935 21 blood blood NN cord-005453-4057qib7 4935 22 and and CC cord-005453-4057qib7 4935 23 confirmed confirm VBD cord-005453-4057qib7 4935 24 nondeleted nondeleted JJ cord-005453-4057qib7 4935 25 , , , cord-005453-4057qib7 4935 26 for for IN cord-005453-4057qib7 4935 27 24 24 CD cord-005453-4057qib7 4935 28 hours hour NNS cord-005453-4057qib7 4935 29 , , , cord-005453-4057qib7 4935 30 and and CC cord-005453-4057qib7 4935 31 re re VBN cord-005453-4057qib7 4935 32 - - VBN cord-005453-4057qib7 4935 33 infused infused JJ cord-005453-4057qib7 4935 34 to to IN cord-005453-4057qib7 4935 35 the the DT cord-005453-4057qib7 4935 36 patient patient NN cord-005453-4057qib7 4935 37 without without IN cord-005453-4057qib7 4935 38 any any DT cord-005453-4057qib7 4935 39 conditioning conditioning NN cord-005453-4057qib7 4935 40 . . . cord-005453-4057qib7 4936 1 Patients patient NNS cord-005453-4057qib7 4936 2 were be VBD cord-005453-4057qib7 4936 3 followed follow VBN cord-005453-4057qib7 4936 4 for for IN cord-005453-4057qib7 4936 5 clinical clinical JJ cord-005453-4057qib7 4936 6 and and CC cord-005453-4057qib7 4936 7 metabolic metabolic JJ cord-005453-4057qib7 4936 8 parameters parameter NNS cord-005453-4057qib7 4936 9 . . . cord-005453-4057qib7 4937 1 Results result NNS cord-005453-4057qib7 4937 2 : : : cord-005453-4057qib7 4938 1 All all DT cord-005453-4057qib7 4938 2 four four CD cord-005453-4057qib7 4938 3 patients patient NNS cord-005453-4057qib7 4938 4 presented present VBN cord-005453-4057qib7 4938 5 with with IN cord-005453-4057qib7 4938 6 different different JJ cord-005453-4057qib7 4938 7 deletions deletion NNS cord-005453-4057qib7 4938 8 in in IN cord-005453-4057qib7 4938 9 mitochondrial mitochondrial JJ cord-005453-4057qib7 4938 10 DNA dna NN cord-005453-4057qib7 4938 11 , , , cord-005453-4057qib7 4938 12 and and CC cord-005453-4057qib7 4938 13 different different JJ cord-005453-4057qib7 4938 14 baseline baseline JJ cord-005453-4057qib7 4938 15 characteristics characteristic NNS cord-005453-4057qib7 4938 16 , , , cord-005453-4057qib7 4938 17 and and CC cord-005453-4057qib7 4938 18 were be VBD cord-005453-4057qib7 4938 19 treated treat VBN cord-005453-4057qib7 4938 20 at at IN cord-005453-4057qib7 4938 21 the the DT cord-005453-4057qib7 4938 22 age age NN cord-005453-4057qib7 4938 23 of of IN cord-005453-4057qib7 4938 24 6.5 6.5 CD cord-005453-4057qib7 4938 25 , , , cord-005453-4057qib7 4938 26 7 7 CD cord-005453-4057qib7 4938 27 , , , cord-005453-4057qib7 4938 28 11 11 CD cord-005453-4057qib7 4938 29 and and CC cord-005453-4057qib7 4938 30 14 14 CD cord-005453-4057qib7 4938 31 years year NNS cord-005453-4057qib7 4938 32 . . . cord-005453-4057qib7 4939 1 Despite despite IN cord-005453-4057qib7 4939 2 normal normal JJ cord-005453-4057qib7 4939 3 CBC CBC NNP cord-005453-4057qib7 4939 4 , , , cord-005453-4057qib7 4939 5 significant significant JJ cord-005453-4057qib7 4939 6 bone bone NN cord-005453-4057qib7 4939 7 marrow marrow NN cord-005453-4057qib7 4939 8 hypocellularity hypocellularity NN cord-005453-4057qib7 4939 9 was be VBD cord-005453-4057qib7 4939 10 seen see VBN cord-005453-4057qib7 4939 11 in in IN cord-005453-4057qib7 4939 12 3 3 CD cord-005453-4057qib7 4939 13 evaluated evaluate VBN cord-005453-4057qib7 4939 14 patients patient NNS cord-005453-4057qib7 4939 15 ( ( -LRB- cord-005453-4057qib7 4939 16 20 20 CD cord-005453-4057qib7 4939 17 % % NN cord-005453-4057qib7 4939 18 , , , cord-005453-4057qib7 4939 19 30 30 CD cord-005453-4057qib7 4939 20 % % NN cord-005453-4057qib7 4939 21 and and CC cord-005453-4057qib7 4939 22 50 50 CD cord-005453-4057qib7 4939 23 % % NN cord-005453-4057qib7 4939 24 cellularity cellularity NN cord-005453-4057qib7 4939 25 at at IN cord-005453-4057qib7 4939 26 age age NN cord-005453-4057qib7 4939 27 7 7 CD cord-005453-4057qib7 4939 28 , , , cord-005453-4057qib7 4939 29 11 11 CD cord-005453-4057qib7 4939 30 and and CC cord-005453-4057qib7 4939 31 14 14 CD cord-005453-4057qib7 4939 32 ) ) -RRB- cord-005453-4057qib7 4939 33 , , , cord-005453-4057qib7 4939 34 which which WDT cord-005453-4057qib7 4939 35 correlated correlate VBD cord-005453-4057qib7 4939 36 with with IN cord-005453-4057qib7 4939 37 low low JJ cord-005453-4057qib7 4939 38 colony colony NN cord-005453-4057qib7 4939 39 forming form VBG cord-005453-4057qib7 4939 40 unit unit NN cord-005453-4057qib7 4939 41 capacity capacity NN cord-005453-4057qib7 4939 42 of of IN cord-005453-4057qib7 4939 43 patients patient NNS cord-005453-4057qib7 4939 44 and and CC cord-005453-4057qib7 4939 45 low low JJ cord-005453-4057qib7 4939 46 yield yield NN cord-005453-4057qib7 4939 47 of of IN cord-005453-4057qib7 4939 48 CD34 CD34 NNP cord-005453-4057qib7 4939 49 + + CC cord-005453-4057qib7 4939 50 mobilization mobilization NN cord-005453-4057qib7 4939 51 in in IN cord-005453-4057qib7 4939 52 the the DT cord-005453-4057qib7 4939 53 leukapheresis leukapheresis NN cord-005453-4057qib7 4939 54 product product NN cord-005453-4057qib7 4939 55 . . . cord-005453-4057qib7 4940 1 Patients patient NNS cord-005453-4057qib7 4940 2 received receive VBN cord-005453-4057qib7 4940 3 on on IN cord-005453-4057qib7 4940 4 average average JJ cord-005453-4057qib7 4940 5 2x10 2x10 CD cord-005453-4057qib7 4940 6 6 6 CD cord-005453-4057qib7 4940 7 enriched enrich VBN cord-005453-4057qib7 4940 8 cells cell NNS cord-005453-4057qib7 4940 9 / / SYM cord-005453-4057qib7 4940 10 kg kg NN cord-005453-4057qib7 4940 11 ( ( -LRB- cord-005453-4057qib7 4940 12 range range NN cord-005453-4057qib7 4940 13 , , , cord-005453-4057qib7 4940 14 1.1 1.1 CD cord-005453-4057qib7 4940 15 -2.8 -2.8 CD cord-005453-4057qib7 4940 16 ) ) -RRB- cord-005453-4057qib7 4940 17 , , , cord-005453-4057qib7 4940 18 and and CC cord-005453-4057qib7 4940 19 the the DT cord-005453-4057qib7 4940 20 median median JJ cord-005453-4057qib7 4940 21 enrichment enrichment NN cord-005453-4057qib7 4940 22 of of IN cord-005453-4057qib7 4940 23 CD34 CD34 NNP cord-005453-4057qib7 4940 24 + + CC cord-005453-4057qib7 4940 25 cells cell NNS cord-005453-4057qib7 4940 26 was be VBD cord-005453-4057qib7 4940 27 135 135 CD cord-005453-4057qib7 4940 28 % % NN cord-005453-4057qib7 4940 29 ( ( -LRB- cord-005453-4057qib7 4940 30 range range NN cord-005453-4057qib7 4940 31 , , , cord-005453-4057qib7 4940 32 103 103 CD cord-005453-4057qib7 4940 33 - - SYM cord-005453-4057qib7 4940 34 162 162 CD cord-005453-4057qib7 4940 35 % % NN cord-005453-4057qib7 4940 36 ) ) -RRB- cord-005453-4057qib7 4940 37 . . . cord-005453-4057qib7 4941 1 No no DT cord-005453-4057qib7 4941 2 infusion infusion NN cord-005453-4057qib7 4941 3 reactions reaction NNS cord-005453-4057qib7 4941 4 occurred occur VBD cord-005453-4057qib7 4941 5 , , , cord-005453-4057qib7 4941 6 and and CC cord-005453-4057qib7 4941 7 the the DT cord-005453-4057qib7 4941 8 only only JJ cord-005453-4057qib7 4941 9 severe severe JJ cord-005453-4057qib7 4941 10 adverse adverse JJ cord-005453-4057qib7 4941 11 events event NNS cord-005453-4057qib7 4941 12 of of IN cord-005453-4057qib7 4941 13 this this DT cord-005453-4057qib7 4941 14 cellular cellular JJ cord-005453-4057qib7 4941 15 therapy therapy NN cord-005453-4057qib7 4941 16 were be VBD cord-005453-4057qib7 4941 17 leukapheresis leukapheresis NN cord-005453-4057qib7 4941 18 - - HYPH cord-005453-4057qib7 4941 19 related relate VBN cord-005453-4057qib7 4941 20 anemia anemia NN cord-005453-4057qib7 4941 21 , , , cord-005453-4057qib7 4941 22 hypokalemia hypokalemia NN cord-005453-4057qib7 4941 23 , , , cord-005453-4057qib7 4941 24 hypocalcemia hypocalcemia NN cord-005453-4057qib7 4941 25 and and CC cord-005453-4057qib7 4941 26 alkalosis alkalosis NN cord-005453-4057qib7 4941 27 , , , cord-005453-4057qib7 4941 28 all all DT cord-005453-4057qib7 4941 29 resolved resolve VBN cord-005453-4057qib7 4941 30 promptly promptly RB cord-005453-4057qib7 4941 31 with with IN cord-005453-4057qib7 4941 32 proper proper JJ cord-005453-4057qib7 4941 33 supplementation supplementation NN cord-005453-4057qib7 4941 34 . . . cord-005453-4057qib7 4942 1 Follow follow VB cord-005453-4057qib7 4942 2 - - HYPH cord-005453-4057qib7 4942 3 up up RP cord-005453-4057qib7 4942 4 duration duration NN cord-005453-4057qib7 4942 5 is be VBZ cord-005453-4057qib7 4942 6 variable variable JJ cord-005453-4057qib7 4942 7 , , , cord-005453-4057qib7 4942 8 ranging range VBG cord-005453-4057qib7 4942 9 5 5 CD cord-005453-4057qib7 4942 10 - - SYM cord-005453-4057qib7 4942 11 22 22 CD cord-005453-4057qib7 4942 12 months month NNS cord-005453-4057qib7 4942 13 . . . cord-005453-4057qib7 4943 1 We -PRON- PRP cord-005453-4057qib7 4943 2 were be VBD cord-005453-4057qib7 4943 3 able able JJ cord-005453-4057qib7 4943 4 to to TO cord-005453-4057qib7 4943 5 show show VB cord-005453-4057qib7 4943 6 improvement improvement NN cord-005453-4057qib7 4943 7 in in IN cord-005453-4057qib7 4943 8 mitochondrial mitochondrial JJ cord-005453-4057qib7 4943 9 heteroplasmy heteroplasmy NNP cord-005453-4057qib7 4943 10 ( ( -LRB- cord-005453-4057qib7 4943 11 proportion proportion NN cord-005453-4057qib7 4943 12 of of IN cord-005453-4057qib7 4943 13 deleted delete VBN cord-005453-4057qib7 4943 14 mtDNA mtdna NN cord-005453-4057qib7 4943 15 of of IN cord-005453-4057qib7 4943 16 total total JJ cord-005453-4057qib7 4943 17 mitochondrial mitochondrial JJ cord-005453-4057qib7 4943 18 DNA dna NN cord-005453-4057qib7 4943 19 ) ) -RRB- cord-005453-4057qib7 4943 20 and and CC cord-005453-4057qib7 4943 21 in in IN cord-005453-4057qib7 4943 22 normal normal JJ cord-005453-4057qib7 4943 23 mtDNA mtdna NN cord-005453-4057qib7 4943 24 content content NN cord-005453-4057qib7 4943 25 , , , cord-005453-4057qib7 4943 26 starting start VBG cord-005453-4057qib7 4943 27 1 1 CD cord-005453-4057qib7 4943 28 - - SYM cord-005453-4057qib7 4943 29 5 5 CD cord-005453-4057qib7 4943 30 months month NNS cord-005453-4057qib7 4943 31 from from IN cord-005453-4057qib7 4943 32 cell cell NN cord-005453-4057qib7 4943 33 therapy therapy NN cord-005453-4057qib7 4943 34 , , , cord-005453-4057qib7 4943 35 which which WDT cord-005453-4057qib7 4943 36 correlated correlate VBD cord-005453-4057qib7 4943 37 with with IN cord-005453-4057qib7 4943 38 improved improve VBN cord-005453-4057qib7 4943 39 ATP ATP NNP cord-005453-4057qib7 4943 40 production production NN cord-005453-4057qib7 4943 41 in in IN cord-005453-4057qib7 4943 42 peripheral peripheral JJ cord-005453-4057qib7 4943 43 blood blood NN cord-005453-4057qib7 4943 44 derived derive VBN cord-005453-4057qib7 4943 45 mononuclear mononuclear NN cord-005453-4057qib7 4943 46 cells cell NNS cord-005453-4057qib7 4943 47 . . . cord-005453-4057qib7 4944 1 Clinically clinically RB cord-005453-4057qib7 4944 2 , , , cord-005453-4057qib7 4944 3 patients patient NNS cord-005453-4057qib7 4944 4 showed show VBD cord-005453-4057qib7 4944 5 improvement improvement NN cord-005453-4057qib7 4944 6 in in IN cord-005453-4057qib7 4944 7 aerobic aerobic JJ cord-005453-4057qib7 4944 8 function function NN cord-005453-4057qib7 4944 9 and and CC cord-005453-4057qib7 4944 10 endurance endurance NN cord-005453-4057qib7 4944 11 ( ( -LRB- cord-005453-4057qib7 4944 12 measured measure VBN cord-005453-4057qib7 4944 13 by by IN cord-005453-4057qib7 4944 14 the the DT cord-005453-4057qib7 4944 15 half half JJ cord-005453-4057qib7 4944 16 - - HYPH cord-005453-4057qib7 4944 17 Bruce Bruce NNP cord-005453-4057qib7 4944 18 protocol protocol NN cord-005453-4057qib7 4944 19 , , , cord-005453-4057qib7 4944 20 sit sit VB cord-005453-4057qib7 4944 21 - - HYPH cord-005453-4057qib7 4944 22 to to TO cord-005453-4057qib7 4944 23 - - HYPH cord-005453-4057qib7 4944 24 stand stand VB cord-005453-4057qib7 4944 25 test test NN cord-005453-4057qib7 4944 26 and and CC cord-005453-4057qib7 4944 27 6-minute 6-minute CD cord-005453-4057qib7 4944 28 walk walk NN cord-005453-4057qib7 4944 29 test test NN cord-005453-4057qib7 4944 30 ) ) -RRB- cord-005453-4057qib7 4944 31 , , , cord-005453-4057qib7 4944 32 muscle muscle NN cord-005453-4057qib7 4944 33 strength strength NN cord-005453-4057qib7 4944 34 ( ( -LRB- cord-005453-4057qib7 4944 35 hand hand NN cord-005453-4057qib7 4944 36 - - HYPH cord-005453-4057qib7 4944 37 held hold VBN cord-005453-4057qib7 4944 38 dynamometry dynamometry NN cord-005453-4057qib7 4944 39 ) ) -RRB- cord-005453-4057qib7 4944 40 , , , cord-005453-4057qib7 4944 41 and and CC cord-005453-4057qib7 4944 42 in in IN cord-005453-4057qib7 4944 43 quality quality NN cord-005453-4057qib7 4944 44 of of IN cord-005453-4057qib7 4944 45 life life NN cord-005453-4057qib7 4944 46 , , , cord-005453-4057qib7 4944 47 measured measure VBN cord-005453-4057qib7 4944 48 by by IN cord-005453-4057qib7 4944 49 the the DT cord-005453-4057qib7 4944 50 international international JJ cord-005453-4057qib7 4944 51 pediatric pediatric JJ cord-005453-4057qib7 4944 52 metabolic metabolic JJ cord-005453-4057qib7 4944 53 disability disability NN cord-005453-4057qib7 4944 54 scale scale NN cord-005453-4057qib7 4944 55 . . . cord-005453-4057qib7 4945 1 No no DT cord-005453-4057qib7 4945 2 metabolic metabolic JJ cord-005453-4057qib7 4945 3 crises crisis NNS cord-005453-4057qib7 4945 4 occurred occur VBD cord-005453-4057qib7 4945 5 following follow VBG cord-005453-4057qib7 4945 6 cell cell NN cord-005453-4057qib7 4945 7 infusion infusion NN cord-005453-4057qib7 4945 8 . . . cord-005453-4057qib7 4946 1 Conclusions conclusion NNS cord-005453-4057qib7 4946 2 : : : cord-005453-4057qib7 4947 1 Patients patient NNS cord-005453-4057qib7 4947 2 with with IN cord-005453-4057qib7 4947 3 deletion deletion NN cord-005453-4057qib7 4947 4 in in IN cord-005453-4057qib7 4947 5 mtDNA mtdna NN cord-005453-4057qib7 4947 6 have have VBP cord-005453-4057qib7 4947 7 metabolic metabolic JJ cord-005453-4057qib7 4947 8 dysfunction dysfunction NN cord-005453-4057qib7 4947 9 , , , cord-005453-4057qib7 4947 10 including include VBG cord-005453-4057qib7 4947 11 poor poor JJ cord-005453-4057qib7 4947 12 bone bone NN cord-005453-4057qib7 4947 13 marrow marrow NN cord-005453-4057qib7 4947 14 cellularity cellularity NN cord-005453-4057qib7 4947 15 and and CC cord-005453-4057qib7 4947 16 function function NN cord-005453-4057qib7 4947 17 . . . cord-005453-4057qib7 4948 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 4948 2 stem stem NN cord-005453-4057qib7 4948 3 cells cell NNS cord-005453-4057qib7 4948 4 in in IN cord-005453-4057qib7 4948 5 patients patient NNS cord-005453-4057qib7 4948 6 with with IN cord-005453-4057qib7 4948 7 mtDNA mtdna JJ cord-005453-4057qib7 4948 8 deletions deletion NNS cord-005453-4057qib7 4948 9 can can MD cord-005453-4057qib7 4948 10 be be VB cord-005453-4057qib7 4948 11 enriched enrich VBN cord-005453-4057qib7 4948 12 with with IN cord-005453-4057qib7 4948 13 normal normal JJ cord-005453-4057qib7 4948 14 mitochondria mitochondrion NNS cord-005453-4057qib7 4948 15 , , , cord-005453-4057qib7 4948 16 via via IN cord-005453-4057qib7 4948 17 MAT MAT NNP cord-005453-4057qib7 4948 18 , , , cord-005453-4057qib7 4948 19 as as IN cord-005453-4057qib7 4948 20 first first JJ cord-005453-4057qib7 4948 21 shown show VBN cord-005453-4057qib7 4948 22 in in IN cord-005453-4057qib7 4948 23 our -PRON- PRP$ cord-005453-4057qib7 4948 24 patients patient NNS cord-005453-4057qib7 4948 25 . . . cord-005453-4057qib7 4949 1 This this DT cord-005453-4057qib7 4949 2 novel novel NN cord-005453-4057qib7 4949 3 process process NN cord-005453-4057qib7 4949 4 is be VBZ cord-005453-4057qib7 4949 5 safe safe JJ cord-005453-4057qib7 4949 6 and and CC cord-005453-4057qib7 4949 7 results result NNS cord-005453-4057qib7 4949 8 in in IN cord-005453-4057qib7 4949 9 increase increase NN cord-005453-4057qib7 4949 10 in in IN cord-005453-4057qib7 4949 11 the the DT cord-005453-4057qib7 4949 12 normal normal JJ cord-005453-4057qib7 4949 13 mtDNA mtdna NN cord-005453-4057qib7 4949 14 in in IN cord-005453-4057qib7 4949 15 peripheral peripheral JJ cord-005453-4057qib7 4949 16 blood blood NN cord-005453-4057qib7 4949 17 of of IN cord-005453-4057qib7 4949 18 patients patient NNS cord-005453-4057qib7 4949 19 , , , cord-005453-4057qib7 4949 20 and and CC cord-005453-4057qib7 4949 21 in in IN cord-005453-4057qib7 4949 22 improved improve VBN cord-005453-4057qib7 4949 23 metabolic metabolic JJ cord-005453-4057qib7 4949 24 and and CC cord-005453-4057qib7 4949 25 clinical clinical JJ cord-005453-4057qib7 4949 26 function function NN cord-005453-4057qib7 4949 27 . . . cord-005453-4057qib7 4950 1 Clinical clinical JJ cord-005453-4057qib7 4950 2 Trial Trial NNP cord-005453-4057qib7 4950 3 Registry Registry NNP cord-005453-4057qib7 4950 4 : : : cord-005453-4057qib7 4951 1 Clinicaltrials.gov Clinicaltrials.gov NNP cord-005453-4057qib7 4952 1 NCT03384420 NCT03384420 NNP cord-005453-4057qib7 4952 2 Disclosure Disclosure NNP cord-005453-4057qib7 4952 3 : : : cord-005453-4057qib7 4953 1 Moria Moria NNP cord-005453-4057qib7 4953 2 Blumkin Blumkin NNP cord-005453-4057qib7 4953 3 , , , cord-005453-4057qib7 4953 4 Noa Noa NNP cord-005453-4057qib7 4953 5 Sher Sher NNP cord-005453-4057qib7 4953 6 and and CC cord-005453-4057qib7 4953 7 Natalie Natalie NNP cord-005453-4057qib7 4953 8 Yivgi Yivgi NNP cord-005453-4057qib7 4953 9 Ohana Ohana NNP cord-005453-4057qib7 4954 1 -Minovia -Minovia NNP cord-005453-4057qib7 4954 2 Therapeutics therapeutic NNS cord-005453-4057qib7 4954 3 , , , cord-005453-4057qib7 4954 4 employment employment NN cord-005453-4057qib7 4954 5 P227 p227 NN cord-005453-4057qib7 4954 6 High high JJ cord-005453-4057qib7 4954 7 cytotoxic cytotoxic JJ cord-005453-4057qib7 4954 8 efficiency efficiency NN cord-005453-4057qib7 4954 9 of of IN cord-005453-4057qib7 4954 10 alpharetrovirally alpharetrovirally RB cord-005453-4057qib7 4954 11 engineered engineer VBN cord-005453-4057qib7 4954 12 CD19-specific cd19-specific CD cord-005453-4057qib7 4954 13 chimeric chimeric JJ cord-005453-4057qib7 4954 14 antigen antigen NN cord-005453-4057qib7 4954 15 receptor receptor NN cord-005453-4057qib7 4954 16 natural natural JJ cord-005453-4057qib7 4954 17 killer killer NN cord-005453-4057qib7 4954 18 cells cell NNS cord-005453-4057qib7 4954 19 for for IN cord-005453-4057qib7 4954 20 treatment treatment NN cord-005453-4057qib7 4954 21 of of IN cord-005453-4057qib7 4954 22 acute acute JJ cord-005453-4057qib7 4954 23 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 4954 24 leukemia leukemia NN cord-005453-4057qib7 4954 25 Stephan Stephan NNP cord-005453-4057qib7 4954 26 Müller Müller NNP cord-005453-4057qib7 4954 27 1 1 CD cord-005453-4057qib7 4954 28 , , , cord-005453-4057qib7 4954 29 Tobias Tobias NNP cord-005453-4057qib7 4954 30 Bexte Bexte NNP cord-005453-4057qib7 4954 31 1 1 CD cord-005453-4057qib7 4954 32 , , , cord-005453-4057qib7 4954 33 Annekathrin Annekathrin NNP cord-005453-4057qib7 4954 34 Heinze Heinze NNP cord-005453-4057qib7 4954 35 1 1 CD cord-005453-4057qib7 4954 36 , , , cord-005453-4057qib7 4954 37 Franziska Franziska NNP cord-005453-4057qib7 4954 38 Schenk Schenk NNP cord-005453-4057qib7 4954 39 2 2 CD cord-005453-4057qib7 4954 40 , , , cord-005453-4057qib7 4954 41 Axel Axel NNP cord-005453-4057qib7 4954 42 Schambach Schambach NNP cord-005453-4057qib7 4954 43 3 3 CD cord-005453-4057qib7 4954 44 , , , cord-005453-4057qib7 4954 45 Winfried Winfried NNP cord-005453-4057qib7 4954 46 S. S. NNP cord-005453-4057qib7 4954 47 Wels Wels NNP cord-005453-4057qib7 4954 48 4,5 4,5 CD cord-005453-4057qib7 4954 49 , , , cord-005453-4057qib7 4954 50 Ute Ute NNP cord-005453-4057qib7 4954 51 Modlich Modlich NNP cord-005453-4057qib7 4954 52 2 2 CD cord-005453-4057qib7 4954 53 , , , cord-005453-4057qib7 4954 54 Evelyn Evelyn NNP cord-005453-4057qib7 4954 55 Ullrich Ullrich NNP cord-005453-4057qib7 4954 56 1 1 CD cord-005453-4057qib7 4954 57 , , , cord-005453-4057qib7 4955 1 5 5 CD cord-005453-4057qib7 4955 2 Background background NN cord-005453-4057qib7 4955 3 : : : cord-005453-4057qib7 4956 1 Autologous autologous JJ cord-005453-4057qib7 4956 2 chimeric chimeric JJ cord-005453-4057qib7 4956 3 antigen antigen NN cord-005453-4057qib7 4956 4 receptormodified receptormodifie VBN cord-005453-4057qib7 4956 5 ( ( -LRB- cord-005453-4057qib7 4956 6 CAR car NN cord-005453-4057qib7 4956 7 ) ) -RRB- cord-005453-4057qib7 4956 8 T t NN cord-005453-4057qib7 4956 9 cells cell NNS cord-005453-4057qib7 4956 10 with with IN cord-005453-4057qib7 4956 11 specificity specificity NN cord-005453-4057qib7 4956 12 for for IN cord-005453-4057qib7 4956 13 CD19 CD19 NNP cord-005453-4057qib7 4956 14 showed show VBD cord-005453-4057qib7 4956 15 potent potent JJ cord-005453-4057qib7 4956 16 antitumor antitumor JJ cord-005453-4057qib7 4956 17 efficacy efficacy NN cord-005453-4057qib7 4956 18 in in IN cord-005453-4057qib7 4956 19 clinical clinical JJ cord-005453-4057qib7 4956 20 trials trial NNS cord-005453-4057qib7 4956 21 regarding regard VBG cord-005453-4057qib7 4956 22 relapsed relapse VBN cord-005453-4057qib7 4956 23 and and CC cord-005453-4057qib7 4956 24 refractory refractory JJ cord-005453-4057qib7 4956 25 acute acute JJ cord-005453-4057qib7 4956 26 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 4956 27 leukemia leukemia NN cord-005453-4057qib7 4956 28 ( ( -LRB- cord-005453-4057qib7 4956 29 ALL all DT cord-005453-4057qib7 4956 30 ) ) -RRB- cord-005453-4057qib7 4956 31 . . . cord-005453-4057qib7 4957 1 Natural natural JJ cord-005453-4057qib7 4957 2 killer killer NN cord-005453-4057qib7 4957 3 ( ( -LRB- cord-005453-4057qib7 4957 4 NK NK NNP cord-005453-4057qib7 4957 5 ) ) -RRB- cord-005453-4057qib7 4957 6 cells cell NNS cord-005453-4057qib7 4957 7 are be VBP cord-005453-4057qib7 4957 8 cytotoxic cytotoxic JJ cord-005453-4057qib7 4957 9 lymphocytes lymphocyte NNS cord-005453-4057qib7 4957 10 that that WDT cord-005453-4057qib7 4957 11 are be VBP cord-005453-4057qib7 4957 12 capable capable JJ cord-005453-4057qib7 4957 13 to to TO cord-005453-4057qib7 4957 14 kill kill VB cord-005453-4057qib7 4957 15 their -PRON- PRP$ cord-005453-4057qib7 4957 16 targets target NNS cord-005453-4057qib7 4957 17 in in IN cord-005453-4057qib7 4957 18 a a DT cord-005453-4057qib7 4957 19 non non JJ cord-005453-4057qib7 4957 20 - - JJ cord-005453-4057qib7 4957 21 specific specific JJ cord-005453-4057qib7 4957 22 manner manner NN cord-005453-4057qib7 4957 23 and and CC cord-005453-4057qib7 4957 24 additionally additionally RB cord-005453-4057qib7 4957 25 do do VBP cord-005453-4057qib7 4957 26 not not RB cord-005453-4057qib7 4957 27 cause cause VB cord-005453-4057qib7 4957 28 GvHD GvHD NNP cord-005453-4057qib7 4957 29 . . . cord-005453-4057qib7 4958 1 Therefore therefore RB cord-005453-4057qib7 4958 2 , , , cord-005453-4057qib7 4958 3 using use VBG cord-005453-4057qib7 4958 4 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4958 5 - - HYPH cord-005453-4057qib7 4958 6 NK NK NNP cord-005453-4057qib7 4958 7 cells cell NNS cord-005453-4057qib7 4958 8 exhibits exhibit VBZ cord-005453-4057qib7 4958 9 several several JJ cord-005453-4057qib7 4958 10 advantages advantage NNS cord-005453-4057qib7 4958 11 , , , cord-005453-4057qib7 4958 12 such such JJ cord-005453-4057qib7 4958 13 as as IN cord-005453-4057qib7 4958 14 safety safety NN cord-005453-4057qib7 4958 15 in in IN cord-005453-4057qib7 4958 16 clinical clinical JJ cord-005453-4057qib7 4958 17 use use NN cord-005453-4057qib7 4958 18 , , , cord-005453-4057qib7 4958 19 possible possible JJ cord-005453-4057qib7 4958 20 allogenic allogenic JJ cord-005453-4057qib7 4958 21 settings setting NNS cord-005453-4057qib7 4958 22 and and CC cord-005453-4057qib7 4958 23 the the DT cord-005453-4057qib7 4958 24 potential potential NN cord-005453-4057qib7 4958 25 to to TO cord-005453-4057qib7 4958 26 also also RB cord-005453-4057qib7 4958 27 attack attack VB cord-005453-4057qib7 4958 28 heterologous heterologous NNP cord-005453-4057qib7 4958 29 leukemia leukemia NN cord-005453-4057qib7 4958 30 cells cell NNS cord-005453-4057qib7 4958 31 which which WDT cord-005453-4057qib7 4958 32 lost lose VBD cord-005453-4057qib7 4958 33 CD19 CD19 NNP cord-005453-4057qib7 4958 34 . . . cord-005453-4057qib7 4959 1 Previous previous JJ cord-005453-4057qib7 4959 2 approaches approach NNS cord-005453-4057qib7 4959 3 used use VBD cord-005453-4057qib7 4959 4 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4959 5 - - HYPH cord-005453-4057qib7 4959 6 NK NK NNP cord-005453-4057qib7 4959 7 cells cell NNS cord-005453-4057qib7 4959 8 pre pre VBP cord-005453-4057qib7 4959 9 - - JJ cord-005453-4057qib7 4959 10 stimulated stimulate VBN cord-005453-4057qib7 4959 11 by by IN cord-005453-4057qib7 4959 12 feeder feeder NN cord-005453-4057qib7 4959 13 cells cell NNS cord-005453-4057qib7 4959 14 , , , cord-005453-4057qib7 4959 15 bearing bear VBG cord-005453-4057qib7 4959 16 potential potential JJ cord-005453-4057qib7 4959 17 risks risk NNS cord-005453-4057qib7 4959 18 . . . cord-005453-4057qib7 4960 1 Thus thus RB cord-005453-4057qib7 4960 2 , , , cord-005453-4057qib7 4960 3 we -PRON- PRP cord-005453-4057qib7 4960 4 focused focus VBD cord-005453-4057qib7 4960 5 on on IN cord-005453-4057qib7 4960 6 the the DT cord-005453-4057qib7 4960 7 optimization optimization NN cord-005453-4057qib7 4960 8 of of IN cord-005453-4057qib7 4960 9 generating generate VBG cord-005453-4057qib7 4960 10 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4960 11 - - HYPH cord-005453-4057qib7 4960 12 NK nk NN cord-005453-4057qib7 4960 13 cells cell NNS cord-005453-4057qib7 4960 14 by by IN cord-005453-4057qib7 4960 15 viral viral JJ cord-005453-4057qib7 4960 16 transduction transduction NN cord-005453-4057qib7 4960 17 under under IN cord-005453-4057qib7 4960 18 feeder feeder NN cord-005453-4057qib7 4960 19 - - HYPH cord-005453-4057qib7 4960 20 cell cell NN cord-005453-4057qib7 4960 21 free free JJ cord-005453-4057qib7 4960 22 conditions condition NNS cord-005453-4057qib7 4960 23 . . . cord-005453-4057qib7 4961 1 Methods method NNS cord-005453-4057qib7 4961 2 : : : cord-005453-4057qib7 4961 3 Human human JJ cord-005453-4057qib7 4961 4 NK NK NNP cord-005453-4057qib7 4961 5 cells cell NNS cord-005453-4057qib7 4961 6 were be VBD cord-005453-4057qib7 4961 7 isolated isolate VBN cord-005453-4057qib7 4961 8 from from IN cord-005453-4057qib7 4961 9 healthy healthy JJ cord-005453-4057qib7 4961 10 donor donor NN cord-005453-4057qib7 4961 11 peripheral peripheral JJ cord-005453-4057qib7 4961 12 blood blood NN cord-005453-4057qib7 4961 13 mononuclear mononuclear NN cord-005453-4057qib7 4961 14 cells cell NNS cord-005453-4057qib7 4961 15 via via IN cord-005453-4057qib7 4961 16 CD56 CD56 NNP cord-005453-4057qib7 4961 17 negative negative JJ cord-005453-4057qib7 4961 18 selection selection NN cord-005453-4057qib7 4961 19 . . . cord-005453-4057qib7 4962 1 After after IN cord-005453-4057qib7 4962 2 a a DT cord-005453-4057qib7 4962 3 feeder feeder NN cord-005453-4057qib7 4962 4 - - HYPH cord-005453-4057qib7 4962 5 cell cell NN cord-005453-4057qib7 4962 6 free free JJ cord-005453-4057qib7 4962 7 expansion expansion NN cord-005453-4057qib7 4962 8 phase phase NN cord-005453-4057qib7 4962 9 with with IN cord-005453-4057qib7 4962 10 interleukin interleukin NN cord-005453-4057qib7 4962 11 15 15 CD cord-005453-4057qib7 4962 12 , , , cord-005453-4057qib7 4962 13 transductions transduction NNS cord-005453-4057qib7 4962 14 were be VBD cord-005453-4057qib7 4962 15 performed perform VBN cord-005453-4057qib7 4962 16 with with IN cord-005453-4057qib7 4962 17 an an DT cord-005453-4057qib7 4962 18 EGFP EGFP NNP cord-005453-4057qib7 4962 19 or or CC cord-005453-4057qib7 4962 20 a a DT cord-005453-4057qib7 4962 21 CD19-CAR cd19-car JJ cord-005453-4057qib7 4962 22 encoding encoding NN cord-005453-4057qib7 4962 23 vector vector NN cord-005453-4057qib7 4962 24 at at IN cord-005453-4057qib7 4962 25 different different JJ cord-005453-4057qib7 4962 26 multiplicities multiplicity NNS cord-005453-4057qib7 4962 27 of of IN cord-005453-4057qib7 4962 28 infection infection NN cord-005453-4057qib7 4962 29 ( ( -LRB- cord-005453-4057qib7 4962 30 MOI MOI NNP cord-005453-4057qib7 4962 31 ) ) -RRB- cord-005453-4057qib7 4962 32 . . . cord-005453-4057qib7 4963 1 To to TO cord-005453-4057qib7 4963 2 optimize optimize VB cord-005453-4057qib7 4963 3 gene gene NN cord-005453-4057qib7 4963 4 modification modification NN cord-005453-4057qib7 4963 5 different different JJ cord-005453-4057qib7 4963 6 transduction transduction NN cord-005453-4057qib7 4963 7 enhancers enhancer NNS cord-005453-4057qib7 4963 8 ( ( -LRB- cord-005453-4057qib7 4963 9 Retronectin Retronectin NNP cord-005453-4057qib7 4963 10 and and CC cord-005453-4057qib7 4963 11 Vectofusin-1 Vectofusin-1 NNP cord-005453-4057qib7 4963 12 ) ) -RRB- cord-005453-4057qib7 4963 13 and and CC cord-005453-4057qib7 4963 14 viral viral JJ cord-005453-4057qib7 4963 15 vector vector NN cord-005453-4057qib7 4963 16 systems system NNS cord-005453-4057qib7 4963 17 ( ( -LRB- cord-005453-4057qib7 4963 18 lentiviral lentiviral NNP cord-005453-4057qib7 4963 19 and and CC cord-005453-4057qib7 4963 20 alpharetroviral alpharetroviral NNP cord-005453-4057qib7 4963 21 ) ) -RRB- cord-005453-4057qib7 4963 22 were be VBD cord-005453-4057qib7 4963 23 compared compare VBN cord-005453-4057qib7 4963 24 . . . cord-005453-4057qib7 4964 1 Finally finally RB cord-005453-4057qib7 4964 2 , , , cord-005453-4057qib7 4964 3 generated generate VBD cord-005453-4057qib7 4964 4 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4964 5 - - HYPH cord-005453-4057qib7 4964 6 NK NK NNP cord-005453-4057qib7 4964 7 cells cell NNS cord-005453-4057qib7 4964 8 were be VBD cord-005453-4057qib7 4964 9 tested test VBN cord-005453-4057qib7 4964 10 in in IN cord-005453-4057qib7 4964 11 their -PRON- PRP$ cord-005453-4057qib7 4964 12 ability ability NN cord-005453-4057qib7 4964 13 to to TO cord-005453-4057qib7 4964 14 kill kill VB cord-005453-4057qib7 4964 15 CD19positive CD19positive NNP cord-005453-4057qib7 4964 16 and and CC cord-005453-4057qib7 4964 17 CD19-negative cd19-negative JJ cord-005453-4057qib7 4964 18 cell cell NN cord-005453-4057qib7 4964 19 lines line NNS cord-005453-4057qib7 4964 20 . . . cord-005453-4057qib7 4965 1 Results result NNS cord-005453-4057qib7 4965 2 : : : cord-005453-4057qib7 4965 3 NK NK NNP cord-005453-4057qib7 4965 4 cells cell NNS cord-005453-4057qib7 4965 5 transduced transduce VBN cord-005453-4057qib7 4965 6 with with IN cord-005453-4057qib7 4965 7 a a DT cord-005453-4057qib7 4965 8 lentiviral lentiviral JJ cord-005453-4057qib7 4965 9 EGFP EGFP NNP cord-005453-4057qib7 4965 10 encoding encoding NN cord-005453-4057qib7 4965 11 vector vector NN cord-005453-4057qib7 4965 12 or or CC cord-005453-4057qib7 4965 13 a a DT cord-005453-4057qib7 4965 14 lentiviral lentiviral JJ cord-005453-4057qib7 4965 15 CD19-CAR cd19-car JJ cord-005453-4057qib7 4965 16 vector vector NN cord-005453-4057qib7 4965 17 using use VBG cord-005453-4057qib7 4965 18 Retronectin Retronectin NNP cord-005453-4057qib7 4965 19 and and CC cord-005453-4057qib7 4965 20 Vectofusin-1 Vectofusin-1 NNP cord-005453-4057qib7 4965 21 showed show VBD cord-005453-4057qib7 4965 22 similar similar JJ cord-005453-4057qib7 4965 23 transduction transduction NN cord-005453-4057qib7 4965 24 efficiencies efficiency NNS cord-005453-4057qib7 4965 25 for for IN cord-005453-4057qib7 4965 26 both both DT cord-005453-4057qib7 4965 27 transduction transduction NN cord-005453-4057qib7 4965 28 enhancers enhancer NNS cord-005453-4057qib7 4965 29 ( ( -LRB- cord-005453-4057qib7 4965 30 EGFP EGFP NNP cord-005453-4057qib7 4965 31 : : : cord-005453-4057qib7 4966 1 Retronectin Retronectin NNP cord-005453-4057qib7 4966 2 MOI MOI NNP cord-005453-4057qib7 4966 3 10 10 CD cord-005453-4057qib7 4966 4 : : : cord-005453-4057qib7 4966 5 12.9 12.9 CD cord-005453-4057qib7 4966 6 % % NN cord-005453-4057qib7 4966 7 ; ; : cord-005453-4057qib7 4966 8 Vectofusin-1 Vectofusin-1 NNP cord-005453-4057qib7 4966 9 MOI MOI NNP cord-005453-4057qib7 4966 10 10 10 CD cord-005453-4057qib7 4966 11 : : SYM cord-005453-4057qib7 4966 12 12.8 12.8 CD cord-005453-4057qib7 4966 13 % % NN cord-005453-4057qib7 4966 14 ; ; . cord-005453-4057qib7 4967 1 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4967 2 : : : cord-005453-4057qib7 4967 3 Retronectin Retronectin NNP cord-005453-4057qib7 4967 4 MOI MOI NNP cord-005453-4057qib7 4967 5 5 5 CD cord-005453-4057qib7 4967 6 : : : cord-005453-4057qib7 4967 7 10.7 10.7 CD cord-005453-4057qib7 4967 8 % % NN cord-005453-4057qib7 4967 9 , , , cord-005453-4057qib7 4967 10 MOI MOI NNP cord-005453-4057qib7 4967 11 10 10 CD cord-005453-4057qib7 4967 12 : : SYM cord-005453-4057qib7 4967 13 9.2 9.2 CD cord-005453-4057qib7 4967 14 % % NN cord-005453-4057qib7 4967 15 ; ; : cord-005453-4057qib7 4967 16 Vectofusin-1 Vectofusin-1 NNP cord-005453-4057qib7 4967 17 MOI MOI NNP cord-005453-4057qib7 4967 18 5 5 CD cord-005453-4057qib7 4967 19 : : : cord-005453-4057qib7 4967 20 11.3 11.3 CD cord-005453-4057qib7 4967 21 % % NN cord-005453-4057qib7 4967 22 , , , cord-005453-4057qib7 4967 23 MOI MOI NNP cord-005453-4057qib7 4967 24 10 10 CD cord-005453-4057qib7 4967 25 : : SYM cord-005453-4057qib7 4967 26 14.4 14.4 CD cord-005453-4057qib7 4967 27 % % NN cord-005453-4057qib7 4967 28 ) ) -RRB- cord-005453-4057qib7 4967 29 . . . cord-005453-4057qib7 4968 1 The the DT cord-005453-4057qib7 4968 2 generated generate VBN cord-005453-4057qib7 4968 3 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4968 4 - - HYPH cord-005453-4057qib7 4968 5 NK NK NNP cord-005453-4057qib7 4968 6 cells cell NNS cord-005453-4057qib7 4968 7 showed show VBD cord-005453-4057qib7 4968 8 increased increase VBN cord-005453-4057qib7 4968 9 cytotoxic cytotoxic JJ cord-005453-4057qib7 4968 10 capacity capacity NN cord-005453-4057qib7 4968 11 against against IN cord-005453-4057qib7 4968 12 CD19-positive cd19-positive CD cord-005453-4057qib7 4968 13 cells cell NNS cord-005453-4057qib7 4968 14 compared compare VBN cord-005453-4057qib7 4968 15 to to IN cord-005453-4057qib7 4968 16 nontransduced nontransduced JJ cord-005453-4057qib7 4968 17 ( ( -LRB- cord-005453-4057qib7 4968 18 NT NT NNP cord-005453-4057qib7 4968 19 ) ) -RRB- cord-005453-4057qib7 4968 20 NK NK NNP cord-005453-4057qib7 4968 21 cells cell NNS cord-005453-4057qib7 4968 22 ( ( -LRB- cord-005453-4057qib7 4968 23 72.7 72.7 CD cord-005453-4057qib7 4968 24 % % NN cord-005453-4057qib7 4968 25 vs. vs. IN cord-005453-4057qib7 4968 26 23.6 23.6 CD cord-005453-4057qib7 4968 27 % % NN cord-005453-4057qib7 4968 28 , , , cord-005453-4057qib7 4968 29 effector effector JJ cord-005453-4057qib7 4968 30 to to IN cord-005453-4057qib7 4968 31 target target NN cord-005453-4057qib7 4968 32 ( ( -LRB- cord-005453-4057qib7 4968 33 E e NN cord-005453-4057qib7 4968 34 : : : cord-005453-4057qib7 4968 35 T T NNP cord-005453-4057qib7 4968 36 ) ) -RRB- cord-005453-4057qib7 4968 37 ratio ratio NN cord-005453-4057qib7 4968 38 1:1 1:1 CD cord-005453-4057qib7 4968 39 ) ) -RRB- cord-005453-4057qib7 4968 40 . . . cord-005453-4057qib7 4969 1 Both both DT cord-005453-4057qib7 4969 2 NK NK NNP cord-005453-4057qib7 4969 3 cell cell NN cord-005453-4057qib7 4969 4 populations population NNS cord-005453-4057qib7 4969 5 were be VBD cord-005453-4057qib7 4969 6 equally equally RB cord-005453-4057qib7 4969 7 efficient efficient JJ cord-005453-4057qib7 4969 8 in in IN cord-005453-4057qib7 4969 9 killing kill VBG cord-005453-4057qib7 4969 10 CD19-negative cd19-negative CD cord-005453-4057qib7 4969 11 cells cell NNS cord-005453-4057qib7 4969 12 ( ( -LRB- cord-005453-4057qib7 4969 13 30.5 30.5 CD cord-005453-4057qib7 4969 14 % % NN cord-005453-4057qib7 4969 15 vs. vs. CC cord-005453-4057qib7 4969 16 25.7 25.7 CD cord-005453-4057qib7 4969 17 % % NN cord-005453-4057qib7 4969 18 ) ) -RRB- cord-005453-4057qib7 4969 19 . . . cord-005453-4057qib7 4970 1 Alpharetroviral alpharetroviral JJ cord-005453-4057qib7 4970 2 transduction transduction NN cord-005453-4057qib7 4970 3 of of IN cord-005453-4057qib7 4970 4 NK NK NNP cord-005453-4057qib7 4970 5 cells cell NNS cord-005453-4057qib7 4970 6 with with IN cord-005453-4057qib7 4970 7 an an DT cord-005453-4057qib7 4970 8 EGFP EGFP NNP cord-005453-4057qib7 4970 9 encoding encoding NN cord-005453-4057qib7 4970 10 vector vector NN cord-005453-4057qib7 4970 11 showed show VBD cord-005453-4057qib7 4970 12 higher high JJR cord-005453-4057qib7 4970 13 transduction transduction NN cord-005453-4057qib7 4970 14 rates rate NNS cord-005453-4057qib7 4970 15 with with IN cord-005453-4057qib7 4970 16 Vectofusin-1 Vectofusin-1 NNP cord-005453-4057qib7 4970 17 than than IN cord-005453-4057qib7 4970 18 with with IN cord-005453-4057qib7 4970 19 Retronectin Retronectin NNP cord-005453-4057qib7 4970 20 ( ( -LRB- cord-005453-4057qib7 4970 21 Retronectin Retronectin NNP cord-005453-4057qib7 4970 22 MOI MOI NNP cord-005453-4057qib7 4970 23 1 1 CD cord-005453-4057qib7 4970 24 : : : cord-005453-4057qib7 4970 25 5.3 5.3 CD cord-005453-4057qib7 4970 26 % % NN cord-005453-4057qib7 4970 27 , , , cord-005453-4057qib7 4970 28 MOI MOI NNP cord-005453-4057qib7 4970 29 5 5 CD cord-005453-4057qib7 4970 30 : : : cord-005453-4057qib7 4970 31 9.7 9.7 CD cord-005453-4057qib7 4970 32 % % NN cord-005453-4057qib7 4970 33 ; ; : cord-005453-4057qib7 4970 34 Vectofusin-1 Vectofusin-1 NNP cord-005453-4057qib7 4970 35 MOI MOI NNP cord-005453-4057qib7 4970 36 1 1 CD cord-005453-4057qib7 4970 37 : : : cord-005453-4057qib7 4970 38 55.3 55.3 CD cord-005453-4057qib7 4970 39 % % NN cord-005453-4057qib7 4970 40 , , , cord-005453-4057qib7 4970 41 MOI MOI NNP cord-005453-4057qib7 4970 42 5 5 CD cord-005453-4057qib7 4970 43 : : : cord-005453-4057qib7 4970 44 51.6 51.6 CD cord-005453-4057qib7 4970 45 % % NN cord-005453-4057qib7 4970 46 ) ) -RRB- cord-005453-4057qib7 4970 47 . . . cord-005453-4057qib7 4971 1 Further further RB cord-005453-4057qib7 4971 2 using use VBG cord-005453-4057qib7 4971 3 Vectofusin-1 Vectofusin-1 NNP cord-005453-4057qib7 4971 4 , , , cord-005453-4057qib7 4971 5 similar similar JJ cord-005453-4057qib7 4971 6 transduction transduction NN cord-005453-4057qib7 4971 7 efficiencies efficiency NNS cord-005453-4057qib7 4971 8 could could MD cord-005453-4057qib7 4971 9 be be VB cord-005453-4057qib7 4971 10 achieved achieve VBN cord-005453-4057qib7 4971 11 with with IN cord-005453-4057qib7 4971 12 an an DT cord-005453-4057qib7 4971 13 alpharetroviral alpharetroviral JJ cord-005453-4057qib7 4971 14 CD19-CAR cd19-car JJ cord-005453-4057qib7 4971 15 encoding encoding NN cord-005453-4057qib7 4971 16 vector vector NN cord-005453-4057qib7 4971 17 ( ( -LRB- cord-005453-4057qib7 4971 18 MOI MOI NNP cord-005453-4057qib7 4971 19 1 1 CD cord-005453-4057qib7 4971 20 : : : cord-005453-4057qib7 4971 21 11.1 11.1 CD cord-005453-4057qib7 4971 22 % % NN cord-005453-4057qib7 4971 23 , , , cord-005453-4057qib7 4971 24 MOI MOI NNP cord-005453-4057qib7 4971 25 5 5 CD cord-005453-4057qib7 4971 26 : : : cord-005453-4057qib7 4971 27 49.2 49.2 CD cord-005453-4057qib7 4971 28 % % NN cord-005453-4057qib7 4971 29 , , , cord-005453-4057qib7 4971 30 MOI MOI NNP cord-005453-4057qib7 4971 31 10 10 CD cord-005453-4057qib7 4971 32 : : : cord-005453-4057qib7 4971 33 68.9 68.9 CD cord-005453-4057qib7 4971 34 % % NN cord-005453-4057qib7 4971 35 ) ) -RRB- cord-005453-4057qib7 4971 36 , , , cord-005453-4057qib7 4971 37 outperforming outperform VBG cord-005453-4057qib7 4971 38 the the DT cord-005453-4057qib7 4971 39 efficiencies efficiency NNS cord-005453-4057qib7 4971 40 of of IN cord-005453-4057qib7 4971 41 lentivirally lentivirally RB cord-005453-4057qib7 4971 42 generated generate VBN cord-005453-4057qib7 4971 43 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4971 44 - - HYPH cord-005453-4057qib7 4971 45 NK NK NNP cord-005453-4057qib7 4971 46 cells cell NNS cord-005453-4057qib7 4971 47 in in IN cord-005453-4057qib7 4971 48 the the DT cord-005453-4057qib7 4971 49 same same JJ cord-005453-4057qib7 4971 50 experiments experiment NNS cord-005453-4057qib7 4971 51 ( ( -LRB- cord-005453-4057qib7 4971 52 MOI MOI NNP cord-005453-4057qib7 4971 53 1 1 CD cord-005453-4057qib7 4971 54 : : : cord-005453-4057qib7 4971 55 1.5 1.5 CD cord-005453-4057qib7 4971 56 % % NN cord-005453-4057qib7 4971 57 , , , cord-005453-4057qib7 4971 58 MOI MOI NNP cord-005453-4057qib7 4971 59 5 5 CD cord-005453-4057qib7 4971 60 : : : cord-005453-4057qib7 4971 61 8.4 8.4 CD cord-005453-4057qib7 4971 62 % % NN cord-005453-4057qib7 4971 63 , , , cord-005453-4057qib7 4971 64 MOI MOI NNP cord-005453-4057qib7 4971 65 10 10 CD cord-005453-4057qib7 4971 66 : : SYM cord-005453-4057qib7 4971 67 14.9 14.9 CD cord-005453-4057qib7 4971 68 % % NN cord-005453-4057qib7 4971 69 ) ) -RRB- cord-005453-4057qib7 4971 70 . . . cord-005453-4057qib7 4972 1 Additionally additionally RB cord-005453-4057qib7 4972 2 , , , cord-005453-4057qib7 4972 3 alpharetroviral alpharetroviral JJ cord-005453-4057qib7 4972 4 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4972 5 - - HYPH cord-005453-4057qib7 4972 6 NK NK NNP cord-005453-4057qib7 4972 7 cells cell NNS cord-005453-4057qib7 4972 8 showed show VBD cord-005453-4057qib7 4972 9 a a DT cord-005453-4057qib7 4972 10 higher high JJR cord-005453-4057qib7 4972 11 cell cell NN cord-005453-4057qib7 4972 12 killing killing NN cord-005453-4057qib7 4972 13 activity activity NN cord-005453-4057qib7 4972 14 against against IN cord-005453-4057qib7 4972 15 CD19-positive CD19-positive NNP cord-005453-4057qib7 4972 16 cells cell NNS cord-005453-4057qib7 4972 17 than than IN cord-005453-4057qib7 4972 18 lentiviral lentiviral JJ cord-005453-4057qib7 4972 19 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4972 20 - - HYPH cord-005453-4057qib7 4972 21 NK NK NNP cord-005453-4057qib7 4972 22 cells cell NNS cord-005453-4057qib7 4972 23 or or CC cord-005453-4057qib7 4972 24 NT NT NNP cord-005453-4057qib7 4972 25 - - HYPH cord-005453-4057qib7 4972 26 NK NK NNP cord-005453-4057qib7 4972 27 cells cell NNS cord-005453-4057qib7 4972 28 ( ( -LRB- cord-005453-4057qib7 4972 29 90.5 90.5 CD cord-005453-4057qib7 4972 30 % % NN cord-005453-4057qib7 4972 31 vs. vs. IN cord-005453-4057qib7 4972 32 62.5 62.5 CD cord-005453-4057qib7 4972 33 % % NN cord-005453-4057qib7 4972 34 vs. vs. IN cord-005453-4057qib7 4972 35 9 9 CD cord-005453-4057qib7 4972 36 % % NN cord-005453-4057qib7 4972 37 , , , cord-005453-4057qib7 4972 38 E e NN cord-005453-4057qib7 4972 39 : : : cord-005453-4057qib7 4972 40 T t NN cord-005453-4057qib7 4972 41 ratio ratio NN cord-005453-4057qib7 4972 42 1:1 1:1 CD cord-005453-4057qib7 4972 43 ) ) -RRB- cord-005453-4057qib7 4972 44 . . . cord-005453-4057qib7 4973 1 Interestingly interestingly RB cord-005453-4057qib7 4973 2 , , , cord-005453-4057qib7 4973 3 similar similar JJ cord-005453-4057qib7 4973 4 killing killing NN cord-005453-4057qib7 4973 5 activities activity NNS cord-005453-4057qib7 4973 6 were be VBD cord-005453-4057qib7 4973 7 achieved achieve VBN cord-005453-4057qib7 4973 8 with with IN cord-005453-4057qib7 4973 9 an an DT cord-005453-4057qib7 4973 10 E e NN cord-005453-4057qib7 4973 11 : : : cord-005453-4057qib7 4973 12 T t NN cord-005453-4057qib7 4973 13 ratio ratio NN cord-005453-4057qib7 4973 14 of of IN cord-005453-4057qib7 4973 15 0.5:1 0.5:1 CD cord-005453-4057qib7 4974 1 ( ( -LRB- cord-005453-4057qib7 4974 2 88.9 88.9 CD cord-005453-4057qib7 4974 3 % % NN cord-005453-4057qib7 4974 4 vs. vs. IN cord-005453-4057qib7 4974 5 58.3 58.3 CD cord-005453-4057qib7 4974 6 % % NN cord-005453-4057qib7 4974 7 vs. vs. IN cord-005453-4057qib7 4974 8 10.3 10.3 CD cord-005453-4057qib7 4974 9 % % NN cord-005453-4057qib7 4974 10 ) ) -RRB- cord-005453-4057qib7 4974 11 and and CC cord-005453-4057qib7 4974 12 alpharetroviral alpharetroviral JJ cord-005453-4057qib7 4974 13 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4974 14 - - HYPH cord-005453-4057qib7 4974 15 NK NK NNP cord-005453-4057qib7 4974 16 cells cell NNS cord-005453-4057qib7 4974 17 remained remain VBD cord-005453-4057qib7 4974 18 a a DT cord-005453-4057qib7 4974 19 stable stable JJ cord-005453-4057qib7 4974 20 cytotoxicity cytotoxicity NN cord-005453-4057qib7 4974 21 level level NN cord-005453-4057qib7 4974 22 at at IN cord-005453-4057qib7 4974 23 lower low JJR cord-005453-4057qib7 4974 24 cell cell NN cord-005453-4057qib7 4974 25 concentrations concentration NNS cord-005453-4057qib7 4974 26 down down IN cord-005453-4057qib7 4974 27 to to IN cord-005453-4057qib7 4974 28 an an DT cord-005453-4057qib7 4974 29 E e NN cord-005453-4057qib7 4974 30 : : : cord-005453-4057qib7 4974 31 T t NN cord-005453-4057qib7 4974 32 ratio ratio NN cord-005453-4057qib7 4974 33 of of IN cord-005453-4057qib7 4974 34 0.1:1 0.1:1 NNP cord-005453-4057qib7 4974 35 . . . cord-005453-4057qib7 4975 1 All all DT cord-005453-4057qib7 4975 2 three three CD cord-005453-4057qib7 4975 3 NK NK NNP cord-005453-4057qib7 4975 4 cell cell NN cord-005453-4057qib7 4975 5 populations population NNS cord-005453-4057qib7 4975 6 were be VBD cord-005453-4057qib7 4975 7 equally equally RB cord-005453-4057qib7 4975 8 efficient efficient JJ cord-005453-4057qib7 4975 9 in in IN cord-005453-4057qib7 4975 10 killing kill VBG cord-005453-4057qib7 4975 11 CD19negative cd19negative JJ cord-005453-4057qib7 4975 12 cells cell NNS cord-005453-4057qib7 4975 13 ( ( -LRB- cord-005453-4057qib7 4975 14 16.4 16.4 CD cord-005453-4057qib7 4975 15 % % NN cord-005453-4057qib7 4975 16 vs. vs. IN cord-005453-4057qib7 4975 17 23.6 23.6 CD cord-005453-4057qib7 4975 18 % % NN cord-005453-4057qib7 4975 19 vs. vs. IN cord-005453-4057qib7 4975 20 12.3 12.3 CD cord-005453-4057qib7 4975 21 % % NN cord-005453-4057qib7 4975 22 , , , cord-005453-4057qib7 4975 23 E e NN cord-005453-4057qib7 4975 24 : : : cord-005453-4057qib7 4975 25 T t NN cord-005453-4057qib7 4975 26 ratio ratio NN cord-005453-4057qib7 4975 27 1:1 1:1 CD cord-005453-4057qib7 4975 28 ) ) -RRB- cord-005453-4057qib7 4975 29 . . . cord-005453-4057qib7 4976 1 Conclusions conclusion NNS cord-005453-4057qib7 4976 2 : : : cord-005453-4057qib7 4977 1 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4977 2 - - HYPH cord-005453-4057qib7 4977 3 NK NK NNP cord-005453-4057qib7 4977 4 cells cell NNS cord-005453-4057qib7 4977 5 can can MD cord-005453-4057qib7 4977 6 be be VB cord-005453-4057qib7 4977 7 successfully successfully RB cord-005453-4057qib7 4977 8 generated generate VBN cord-005453-4057qib7 4977 9 under under IN cord-005453-4057qib7 4977 10 feeder feeder NN cord-005453-4057qib7 4977 11 - - HYPH cord-005453-4057qib7 4977 12 cell cell NN cord-005453-4057qib7 4977 13 free free JJ cord-005453-4057qib7 4977 14 conditions condition NNS cord-005453-4057qib7 4977 15 using use VBG cord-005453-4057qib7 4977 16 different different JJ cord-005453-4057qib7 4977 17 transduction transduction NN cord-005453-4057qib7 4977 18 enhancers enhancer NNS cord-005453-4057qib7 4977 19 and and CC cord-005453-4057qib7 4977 20 viral viral JJ cord-005453-4057qib7 4977 21 vector vector NN cord-005453-4057qib7 4977 22 systems system NNS cord-005453-4057qib7 4977 23 . . . cord-005453-4057qib7 4978 1 These these DT cord-005453-4057qib7 4978 2 data datum NNS cord-005453-4057qib7 4978 3 suggest suggest VBP cord-005453-4057qib7 4978 4 the the DT cord-005453-4057qib7 4978 5 usage usage NN cord-005453-4057qib7 4978 6 of of IN cord-005453-4057qib7 4978 7 Vectofusin-1 Vectofusin-1 NNP cord-005453-4057qib7 4978 8 in in IN cord-005453-4057qib7 4978 9 combination combination NN cord-005453-4057qib7 4978 10 with with IN cord-005453-4057qib7 4978 11 alpharetroviral alpharetroviral JJ cord-005453-4057qib7 4978 12 vectors vector NNS cord-005453-4057qib7 4978 13 to to TO cord-005453-4057qib7 4978 14 genetically genetically RB cord-005453-4057qib7 4978 15 modify modify VB cord-005453-4057qib7 4978 16 NK NK NNP cord-005453-4057qib7 4978 17 cells cell NNS cord-005453-4057qib7 4978 18 to to TO cord-005453-4057qib7 4978 19 achieve achieve VB cord-005453-4057qib7 4978 20 sufficient sufficient JJ cord-005453-4057qib7 4978 21 amounts amount NNS cord-005453-4057qib7 4978 22 of of IN cord-005453-4057qib7 4978 23 transduced transduce VBN cord-005453-4057qib7 4978 24 cells cell NNS cord-005453-4057qib7 4978 25 . . . cord-005453-4057qib7 4979 1 These these DT cord-005453-4057qib7 4979 2 CD19-CAR CD19-CAR NNP cord-005453-4057qib7 4979 3 - - HYPH cord-005453-4057qib7 4979 4 NK NK NNP cord-005453-4057qib7 4979 5 cells cell NNS cord-005453-4057qib7 4979 6 mediate mediate VBP cord-005453-4057qib7 4979 7 high high JJ cord-005453-4057qib7 4979 8 cytotoxicity cytotoxicity NN cord-005453-4057qib7 4979 9 and and CC cord-005453-4057qib7 4979 10 therefore therefore RB cord-005453-4057qib7 4979 11 may may MD cord-005453-4057qib7 4979 12 offer offer VB cord-005453-4057qib7 4979 13 a a DT cord-005453-4057qib7 4979 14 new new JJ cord-005453-4057qib7 4979 15 therapeutic therapeutic JJ cord-005453-4057qib7 4979 16 option option NN cord-005453-4057qib7 4979 17 in in IN cord-005453-4057qib7 4979 18 the the DT cord-005453-4057qib7 4979 19 treatment treatment NN cord-005453-4057qib7 4979 20 of of IN cord-005453-4057qib7 4979 21 ALL all DT cord-005453-4057qib7 4979 22 . . . cord-005453-4057qib7 4980 1 Disclosure disclosure NN cord-005453-4057qib7 4980 2 : : : cord-005453-4057qib7 4981 1 Axel Axel NNP cord-005453-4057qib7 4981 2 Schambach Schambach NNP cord-005453-4057qib7 4981 3 is be VBZ cord-005453-4057qib7 4981 4 an an DT cord-005453-4057qib7 4981 5 inventor inventor NN cord-005453-4057qib7 4981 6 on on IN cord-005453-4057qib7 4981 7 a a DT cord-005453-4057qib7 4981 8 patent patent NN cord-005453-4057qib7 4981 9 describing describe VBG cord-005453-4057qib7 4981 10 alpharetroviral alpharetroviral JJ cord-005453-4057qib7 4981 11 SIN sin NN cord-005453-4057qib7 4981 12 vectors vector NNS cord-005453-4057qib7 4981 13 . . . cord-005453-4057qib7 4982 1 Winfried Winfried NNP cord-005453-4057qib7 4982 2 S. S. NNP cord-005453-4057qib7 4982 3 Wels Wels NNP cord-005453-4057qib7 4982 4 is be VBZ cord-005453-4057qib7 4982 5 an an DT cord-005453-4057qib7 4982 6 inventor inventor NN cord-005453-4057qib7 4982 7 on on IN cord-005453-4057qib7 4982 8 a a DT cord-005453-4057qib7 4982 9 patent patent NN cord-005453-4057qib7 4982 10 describing describe VBG cord-005453-4057qib7 4982 11 chimeric chimeric JJ cord-005453-4057qib7 4982 12 antigen antigen NN cord-005453-4057qib7 4982 13 receptors receptor NNS cord-005453-4057qib7 4982 14 with with IN cord-005453-4057qib7 4982 15 an an DT cord-005453-4057qib7 4982 16 optimized optimize VBN cord-005453-4057qib7 4982 17 hinge hinge NN cord-005453-4057qib7 4982 18 region region NN cord-005453-4057qib7 4982 19 . . . cord-005453-4057qib7 4983 1 The the DT cord-005453-4057qib7 4983 2 remaining remain VBG cord-005453-4057qib7 4983 3 authors author NNS cord-005453-4057qib7 4983 4 have have VBP cord-005453-4057qib7 4983 5 nothing nothing NN cord-005453-4057qib7 4983 6 to to TO cord-005453-4057qib7 4983 7 disclose disclose VB cord-005453-4057qib7 4983 8 . . . cord-005453-4057qib7 4984 1 Graft graft NN cord-005453-4057qib7 4984 2 - - HYPH cord-005453-4057qib7 4984 3 versus versus IN cord-005453-4057qib7 4984 4 - - HYPH cord-005453-4057qib7 4984 5 host host NN cord-005453-4057qib7 4984 6 diseaseclinical diseaseclinical JJ cord-005453-4057qib7 4984 7 Walter Walter NNP cord-005453-4057qib7 4984 8 Spindelböck Spindelböck NNP cord-005453-4057qib7 4984 9 1 1 CD cord-005453-4057qib7 4984 10 , , , cord-005453-4057qib7 4985 1 Bianca Bianca NNP cord-005453-4057qib7 4985 2 Huber Huber NNP cord-005453-4057qib7 4985 3 - - HYPH cord-005453-4057qib7 4985 4 Krassnitzer Krassnitzer NNP cord-005453-4057qib7 4985 5 1 1 CD cord-005453-4057qib7 4985 6 , , , cord-005453-4057qib7 4985 7 Barbara Barbara NNP cord-005453-4057qib7 4985 8 Uhl Uhl NNP cord-005453-4057qib7 4985 9 1 1 CD cord-005453-4057qib7 4985 10 , , , cord-005453-4057qib7 4985 11 Gregor Gregor NNP cord-005453-4057qib7 4985 12 Gorkiewicz Gorkiewicz NNP cord-005453-4057qib7 4985 13 1 1 CD cord-005453-4057qib7 4985 14 , , , cord-005453-4057qib7 4985 15 Hildegard Hildegard NNP cord-005453-4057qib7 4985 16 Greinix Greinix NNP cord-005453-4057qib7 4985 17 1 1 CD cord-005453-4057qib7 4985 18 , , , cord-005453-4057qib7 4985 19 Christoph Christoph NNP cord-005453-4057qib7 4985 20 Högenauer Högenauer NNP cord-005453-4057qib7 4985 21 1 1 CD cord-005453-4057qib7 4985 22 , , , cord-005453-4057qib7 4985 23 Peter Peter NNP cord-005453-4057qib7 4985 24 Neumeister Neumeister NNP cord-005453-4057qib7 4985 25 1 1 CD cord-005453-4057qib7 4985 26 Background Background NNP cord-005453-4057qib7 4985 27 : : : cord-005453-4057qib7 4985 28 Steroid steroid JJ cord-005453-4057qib7 4985 29 - - HYPH cord-005453-4057qib7 4985 30 refractory refractory JJ cord-005453-4057qib7 4985 31 acute acute JJ cord-005453-4057qib7 4985 32 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 4985 33 ( ( -LRB- cord-005453-4057qib7 4985 34 GI GI NNP cord-005453-4057qib7 4985 35 ) ) -RRB- cord-005453-4057qib7 4985 36 graft graft NN cord-005453-4057qib7 4985 37 - - HYPH cord-005453-4057qib7 4985 38 versus versus IN cord-005453-4057qib7 4985 39 - - HYPH cord-005453-4057qib7 4985 40 host host NN cord-005453-4057qib7 4985 41 disease disease NN cord-005453-4057qib7 4985 42 ( ( -LRB- cord-005453-4057qib7 4985 43 aGvHD agvhd NN cord-005453-4057qib7 4985 44 ) ) -RRB- cord-005453-4057qib7 4985 45 is be VBZ cord-005453-4057qib7 4985 46 a a DT cord-005453-4057qib7 4985 47 severe severe JJ cord-005453-4057qib7 4985 48 complication complication NN cord-005453-4057qib7 4985 49 of of IN cord-005453-4057qib7 4985 50 allogeneic allogeneic NN cord-005453-4057qib7 4985 51 hematopoietic hematopoietic JJ cord-005453-4057qib7 4985 52 stem stem NN cord-005453-4057qib7 4985 53 cell cell NN cord-005453-4057qib7 4985 54 transplantation transplantation NN cord-005453-4057qib7 4985 55 ( ( -LRB- cord-005453-4057qib7 4985 56 allo allo NN cord-005453-4057qib7 4985 57 - - HYPH cord-005453-4057qib7 4985 58 HSCT HSCT NNP cord-005453-4057qib7 4985 59 ) ) -RRB- cord-005453-4057qib7 4985 60 associated associate VBD cord-005453-4057qib7 4985 61 with with IN cord-005453-4057qib7 4985 62 a a DT cord-005453-4057qib7 4985 63 high high JJ cord-005453-4057qib7 4985 64 mortality mortality NN cord-005453-4057qib7 4985 65 rate rate NN cord-005453-4057qib7 4985 66 . . . cord-005453-4057qib7 4986 1 Loss loss NN cord-005453-4057qib7 4986 2 of of IN cord-005453-4057qib7 4986 3 intestinal intestinal JJ cord-005453-4057qib7 4986 4 bacterial bacterial JJ cord-005453-4057qib7 4986 5 diversity diversity NN cord-005453-4057qib7 4986 6 is be VBZ cord-005453-4057qib7 4986 7 thought think VBN cord-005453-4057qib7 4986 8 to to TO cord-005453-4057qib7 4986 9 be be VB cord-005453-4057qib7 4986 10 associated associate VBN cord-005453-4057qib7 4986 11 with with IN cord-005453-4057qib7 4986 12 severity severity NN cord-005453-4057qib7 4986 13 of of IN cord-005453-4057qib7 4986 14 GI GI NNP cord-005453-4057qib7 4986 15 - - HYPH cord-005453-4057qib7 4986 16 aGvHD aGvHD NNP cord-005453-4057qib7 4986 17 and and CC cord-005453-4057qib7 4986 18 an an DT cord-005453-4057qib7 4986 19 impaired impaired JJ cord-005453-4057qib7 4986 20 intestinal intestinal JJ cord-005453-4057qib7 4986 21 microbiota microbiota NN cord-005453-4057qib7 4986 22 with with IN cord-005453-4057qib7 4986 23 reduced reduce VBN cord-005453-4057qib7 4986 24 diversity diversity NN cord-005453-4057qib7 4986 25 is be VBZ cord-005453-4057qib7 4986 26 an an DT cord-005453-4057qib7 4986 27 independent independent JJ cord-005453-4057qib7 4986 28 predictor predictor NN cord-005453-4057qib7 4986 29 of of IN cord-005453-4057qib7 4986 30 mortality mortality NN cord-005453-4057qib7 4986 31 . . . cord-005453-4057qib7 4987 1 Methods method NNS cord-005453-4057qib7 4987 2 : : : cord-005453-4057qib7 4988 1 The the DT cord-005453-4057qib7 4988 2 fecal fecal JJ cord-005453-4057qib7 4988 3 microbiota microbiota NN cord-005453-4057qib7 4988 4 transplantation transplantation NN cord-005453-4057qib7 4988 5 ( ( -LRB- cord-005453-4057qib7 4988 6 FMT fmt NN cord-005453-4057qib7 4988 7 ) ) -RRB- cord-005453-4057qib7 4988 8 procedures procedure NNS cord-005453-4057qib7 4988 9 were be VBD cord-005453-4057qib7 4988 10 performed perform VBN cord-005453-4057qib7 4988 11 according accord VBG cord-005453-4057qib7 4988 12 to to IN cord-005453-4057qib7 4988 13 a a DT cord-005453-4057qib7 4988 14 protocol protocol NN cord-005453-4057qib7 4988 15 approved approve VBN cord-005453-4057qib7 4988 16 by by IN cord-005453-4057qib7 4988 17 the the DT cord-005453-4057qib7 4988 18 local local JJ cord-005453-4057qib7 4988 19 ethical ethical JJ cord-005453-4057qib7 4988 20 committee committee NN cord-005453-4057qib7 4988 21 ( ( -LRB- cord-005453-4057qib7 4988 22 29 29 CD cord-005453-4057qib7 4988 23 - - HYPH cord-005453-4057qib7 4988 24 027ex 027ex NN cord-005453-4057qib7 4988 25 16/17 16/17 CD cord-005453-4057qib7 4988 26 ) ) -RRB- cord-005453-4057qib7 4988 27 after after IN cord-005453-4057qib7 4988 28 obtaining obtain VBG cord-005453-4057qib7 4988 29 informed informed JJ cord-005453-4057qib7 4988 30 consent consent NN cord-005453-4057qib7 4988 31 . . . cord-005453-4057qib7 4989 1 Donors donor NNS cord-005453-4057qib7 4989 2 were be VBD cord-005453-4057qib7 4989 3 healthy healthy JJ cord-005453-4057qib7 4989 4 adult adult NN cord-005453-4057qib7 4989 5 subjects subject NNS cord-005453-4057qib7 4989 6 screened screen VBN cord-005453-4057qib7 4989 7 for for IN cord-005453-4057qib7 4989 8 potential potential JJ cord-005453-4057qib7 4989 9 infections infection NNS cord-005453-4057qib7 4989 10 by by IN cord-005453-4057qib7 4989 11 serologic serologic NN cord-005453-4057qib7 4989 12 and and CC cord-005453-4057qib7 4989 13 microbiologic microbiologic JJ cord-005453-4057qib7 4989 14 tests test NNS cord-005453-4057qib7 4989 15 according accord VBG cord-005453-4057qib7 4989 16 to to IN cord-005453-4057qib7 4989 17 local local JJ cord-005453-4057qib7 4989 18 standards standard NNS cord-005453-4057qib7 4989 19 . . . cord-005453-4057qib7 4990 1 Donor donor NN cord-005453-4057qib7 4990 2 stool stool NN cord-005453-4057qib7 4990 3 was be VBD cord-005453-4057qib7 4990 4 diluted dilute VBN cord-005453-4057qib7 4990 5 with with IN cord-005453-4057qib7 4990 6 saline saline NN cord-005453-4057qib7 4990 7 and and CC cord-005453-4057qib7 4990 8 homogenized homogenize VBN cord-005453-4057qib7 4990 9 to to IN cord-005453-4057qib7 4990 10 a a DT cord-005453-4057qib7 4990 11 volume volume NN cord-005453-4057qib7 4990 12 of~250 of~250 NNP cord-005453-4057qib7 4990 13 ml ml XX cord-005453-4057qib7 4990 14 fecal fecal JJ cord-005453-4057qib7 4990 15 solution solution NN cord-005453-4057qib7 4990 16 for for IN cord-005453-4057qib7 4990 17 instillation instillation NN cord-005453-4057qib7 4990 18 into into IN cord-005453-4057qib7 4990 19 the the DT cord-005453-4057qib7 4990 20 terminal terminal JJ cord-005453-4057qib7 4990 21 ileum ileum NN cord-005453-4057qib7 4990 22 and and CC cord-005453-4057qib7 4990 23 caecum caecum NN cord-005453-4057qib7 4990 24 via via IN cord-005453-4057qib7 4990 25 colonoscope colonoscope NN cord-005453-4057qib7 4990 26 . . . cord-005453-4057qib7 4991 1 Microbiota Microbiota NNP cord-005453-4057qib7 4991 2 sequencing sequencing NN cord-005453-4057qib7 4991 3 analysis analysis NN cord-005453-4057qib7 4991 4 of of IN cord-005453-4057qib7 4991 5 16s 16s NNPS cord-005453-4057qib7 4991 6 rDNA rDNA NNP cord-005453-4057qib7 4991 7 was be VBD cord-005453-4057qib7 4991 8 performed perform VBN cord-005453-4057qib7 4991 9 before before IN cord-005453-4057qib7 4991 10 FMTs fmt NNS cord-005453-4057qib7 4991 11 and and CC cord-005453-4057qib7 4991 12 afterwards afterwards RB cord-005453-4057qib7 4991 13 at at IN cord-005453-4057qib7 4991 14 predefined predefined JJ cord-005453-4057qib7 4991 15 timepoints timepoint NNS cord-005453-4057qib7 4991 16 . . . cord-005453-4057qib7 4992 1 Results result NNS cord-005453-4057qib7 4992 2 : : : cord-005453-4057qib7 4993 1 We -PRON- PRP cord-005453-4057qib7 4993 2 report report VBP cord-005453-4057qib7 4993 3 the the DT cord-005453-4057qib7 4993 4 outcome outcome NN cord-005453-4057qib7 4993 5 of of IN cord-005453-4057qib7 4993 6 nine nine CD cord-005453-4057qib7 4993 7 patients patient NNS cord-005453-4057qib7 4993 8 refractory refractory JJ cord-005453-4057qib7 4993 9 to to IN cord-005453-4057qib7 4993 10 3 3 CD cord-005453-4057qib7 4993 11 - - SYM cord-005453-4057qib7 4993 12 6 6 CD cord-005453-4057qib7 4993 13 lines line NNS cord-005453-4057qib7 4993 14 of of IN cord-005453-4057qib7 4993 15 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4993 16 therapies therapy NNS cord-005453-4057qib7 4993 17 with with IN cord-005453-4057qib7 4993 18 lower low JJR cord-005453-4057qib7 4993 19 GI gi NN cord-005453-4057qib7 4993 20 - - HYPH cord-005453-4057qib7 4993 21 stage stage NN cord-005453-4057qib7 4993 22 III III NNP cord-005453-4057qib7 4993 23 ( ( -LRB- cord-005453-4057qib7 4993 24 n=1 n=1 NN cord-005453-4057qib7 4993 25 ) ) -RRB- cord-005453-4057qib7 4993 26 or or CC cord-005453-4057qib7 4993 27 IV IV NNP cord-005453-4057qib7 4993 28 ( ( -LRB- cord-005453-4057qib7 4993 29 n=8 n=8 NN cord-005453-4057qib7 4993 30 ) ) -RRB- cord-005453-4057qib7 4993 31 aGvHD aGvHD . cord-005453-4057qib7 4993 32 following follow VBG cord-005453-4057qib7 4993 33 repetitive repetitive JJ cord-005453-4057qib7 4993 34 FMTs fmt NNS cord-005453-4057qib7 4993 35 from from IN cord-005453-4057qib7 4993 36 a a DT cord-005453-4057qib7 4993 37 single single JJ cord-005453-4057qib7 4993 38 donor donor NN cord-005453-4057qib7 4993 39 . . . cord-005453-4057qib7 4994 1 All all DT cord-005453-4057qib7 4994 2 patients patient NNS cord-005453-4057qib7 4994 3 had have VBD cord-005453-4057qib7 4994 4 received receive VBN cord-005453-4057qib7 4994 5 an an DT cord-005453-4057qib7 4994 6 allo allo NN cord-005453-4057qib7 4994 7 - - HYPH cord-005453-4057qib7 4994 8 HSCT HSCT NNP cord-005453-4057qib7 4994 9 for for IN cord-005453-4057qib7 4994 10 MDS MDS NNP cord-005453-4057qib7 4994 11 ( ( -LRB- cord-005453-4057qib7 4994 12 n=3 n=3 NN cord-005453-4057qib7 4994 13 ) ) -RRB- cord-005453-4057qib7 4994 14 , , , cord-005453-4057qib7 4994 15 AML AML NNP cord-005453-4057qib7 4994 16 ( ( -LRB- cord-005453-4057qib7 4994 17 n=4 n=4 NNP cord-005453-4057qib7 4994 18 ) ) -RRB- cord-005453-4057qib7 4994 19 , , , cord-005453-4057qib7 4994 20 PMF PMF NNP cord-005453-4057qib7 4994 21 ( ( -LRB- cord-005453-4057qib7 4994 22 n=1 n=1 NNP cord-005453-4057qib7 4994 23 ) ) -RRB- cord-005453-4057qib7 4994 24 and and CC cord-005453-4057qib7 4994 25 MM MM NNP cord-005453-4057qib7 4994 26 ( ( -LRB- cord-005453-4057qib7 4994 27 n=1 n=1 FW cord-005453-4057qib7 4994 28 ) ) -RRB- cord-005453-4057qib7 4994 29 following follow VBG cord-005453-4057qib7 4994 30 a a DT cord-005453-4057qib7 4994 31 reduced reduce VBN cord-005453-4057qib7 4994 32 intensity intensity NN cord-005453-4057qib7 4994 33 ( ( -LRB- cord-005453-4057qib7 4994 34 n=5 n=5 NNP cord-005453-4057qib7 4994 35 ) ) -RRB- cord-005453-4057qib7 4994 36 or or CC cord-005453-4057qib7 4994 37 MAC MAC NNP cord-005453-4057qib7 4994 38 ( ( -LRB- cord-005453-4057qib7 4994 39 n=4 n=4 JJ cord-005453-4057qib7 4994 40 ) ) -RRB- cord-005453-4057qib7 4994 41 conditioning conditioning NN cord-005453-4057qib7 4994 42 regimen regimen NN cord-005453-4057qib7 4994 43 using use VBG cord-005453-4057qib7 4994 44 PBSC PBSC NNP cord-005453-4057qib7 4994 45 as as IN cord-005453-4057qib7 4994 46 stem stem NN cord-005453-4057qib7 4994 47 cell cell NN cord-005453-4057qib7 4994 48 source source NN cord-005453-4057qib7 4994 49 . . . cord-005453-4057qib7 4995 1 After after IN cord-005453-4057qib7 4995 2 an an DT cord-005453-4057qib7 4995 3 onset onset NN cord-005453-4057qib7 4995 4 of of IN cord-005453-4057qib7 4995 5 lower low JJR cord-005453-4057qib7 4995 6 GI GI NNP cord-005453-4057qib7 4995 7 aGvHD agvhd NN cord-005453-4057qib7 4995 8 between between IN cord-005453-4057qib7 4995 9 11 11 CD cord-005453-4057qib7 4995 10 - - SYM cord-005453-4057qib7 4995 11 465 465 CD cord-005453-4057qib7 4995 12 days day NNS cord-005453-4057qib7 4995 13 after after IN cord-005453-4057qib7 4995 14 allo allo NN cord-005453-4057qib7 4995 15 - - HYPH cord-005453-4057qib7 4995 16 HSCT HSCT NNP cord-005453-4057qib7 4995 17 , , , cord-005453-4057qib7 4995 18 nine nine CD cord-005453-4057qib7 4995 19 patients patient NNS cord-005453-4057qib7 4995 20 refractory refractory JJ cord-005453-4057qib7 4995 21 to to IN cord-005453-4057qib7 4995 22 several several JJ cord-005453-4057qib7 4995 23 lines line NNS cord-005453-4057qib7 4995 24 of of IN cord-005453-4057qib7 4995 25 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 4995 26 therapies therapy NNS cord-005453-4057qib7 4995 27 received receive VBD cord-005453-4057qib7 4995 28 1 1 CD cord-005453-4057qib7 4995 29 - - SYM cord-005453-4057qib7 4995 30 6 6 CD cord-005453-4057qib7 4995 31 FMTs fmt NNS cord-005453-4057qib7 4995 32 ( ( -LRB- cord-005453-4057qib7 4995 33 6 6 CD cord-005453-4057qib7 4995 34 patients patient NNS cord-005453-4057qib7 4995 35 were be VBD cord-005453-4057qib7 4995 36 treated treat VBN cord-005453-4057qib7 4995 37 with with IN cord-005453-4057qib7 4995 38 more more JJR cord-005453-4057qib7 4995 39 than than IN cord-005453-4057qib7 4995 40 2 2 CD cord-005453-4057qib7 4995 41 FMTs fmt NNS cord-005453-4057qib7 4995 42 , , , cord-005453-4057qib7 4995 43 in in IN cord-005453-4057qib7 4995 44 3 3 CD cord-005453-4057qib7 4995 45 patients patient NNS cord-005453-4057qib7 4995 46 FMT fmt NN cord-005453-4057qib7 4995 47 was be VBD cord-005453-4057qib7 4995 48 only only RB cord-005453-4057qib7 4995 49 administered administer VBN cord-005453-4057qib7 4995 50 once once RB cord-005453-4057qib7 4995 51 or or CC cord-005453-4057qib7 4995 52 twice twice RB cord-005453-4057qib7 4995 53 ) ) -RRB- cord-005453-4057qib7 4995 54 mostly mostly RB cord-005453-4057qib7 4995 55 in in IN cord-005453-4057qib7 4995 56 weekly weekly JJ cord-005453-4057qib7 4995 57 intervals interval NNS cord-005453-4057qib7 4995 58 . . . cord-005453-4057qib7 4996 1 Five five CD cord-005453-4057qib7 4996 2 patients patient NNS cord-005453-4057qib7 4996 3 achieved achieve VBD cord-005453-4057qib7 4996 4 a a DT cord-005453-4057qib7 4996 5 clinical clinical JJ cord-005453-4057qib7 4996 6 complete complete JJ cord-005453-4057qib7 4996 7 response response NN cord-005453-4057qib7 4996 8 with with IN cord-005453-4057qib7 4996 9 resolved resolve VBN cord-005453-4057qib7 4996 10 diarrhea diarrhea NN cord-005453-4057qib7 4996 11 and and CC cord-005453-4057qib7 4996 12 no no DT cord-005453-4057qib7 4996 13 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 4996 14 complaints complaint NNS cord-005453-4057qib7 4996 15 , , , cord-005453-4057qib7 4996 16 and and CC cord-005453-4057qib7 4996 17 four four CD cord-005453-4057qib7 4996 18 of of IN cord-005453-4057qib7 4996 19 these these DT cord-005453-4057qib7 4996 20 could could MD cord-005453-4057qib7 4996 21 be be VB cord-005453-4057qib7 4996 22 discharged discharge VBN cord-005453-4057qib7 4996 23 without without IN cord-005453-4057qib7 4996 24 GvHD gvhd NN cord-005453-4057qib7 4996 25 symptoms symptom NNS cord-005453-4057qib7 4996 26 . . . cord-005453-4057qib7 4997 1 Two two CD cord-005453-4057qib7 4997 2 patients patient NNS cord-005453-4057qib7 4997 3 ( ( -LRB- cord-005453-4057qib7 4997 4 PR PR NNP cord-005453-4057qib7 4997 5 , , , cord-005453-4057qib7 4997 6 NC NC NNP cord-005453-4057qib7 4997 7 ) ) -RRB- cord-005453-4057qib7 4997 8 were be VBD cord-005453-4057qib7 4997 9 discontinued discontinue VBN cord-005453-4057qib7 4997 10 after after IN cord-005453-4057qib7 4997 11 2 2 CD cord-005453-4057qib7 4997 12 or or CC cord-005453-4057qib7 4997 13 3 3 CD cord-005453-4057qib7 4997 14 FMTs fmt NNS cord-005453-4057qib7 4997 15 in in IN cord-005453-4057qib7 4997 16 PR PR NNP cord-005453-4057qib7 4997 17 or or CC cord-005453-4057qib7 4997 18 NC NC NNP cord-005453-4057qib7 4997 19 due due JJ cord-005453-4057qib7 4997 20 to to IN cord-005453-4057qib7 4997 21 concomitant concomitant JJ cord-005453-4057qib7 4997 22 infections infection NNS cord-005453-4057qib7 4997 23 ( ( -LRB- cord-005453-4057qib7 4997 24 Metapneumoviral Metapneumoviral NNP cord-005453-4057qib7 4997 25 pneumonia pneumonia NN cord-005453-4057qib7 4997 26 , , , cord-005453-4057qib7 4997 27 CMV CMV NNP cord-005453-4057qib7 4997 28 gastroenteritis gastroenteritis NN cord-005453-4057qib7 4997 29 ) ) -RRB- cord-005453-4057qib7 4997 30 , , , cord-005453-4057qib7 4997 31 the the DT cord-005453-4057qib7 4997 32 2 2 CD cord-005453-4057qib7 4997 33 other other JJ cord-005453-4057qib7 4997 34 non non NNS cord-005453-4057qib7 4997 35 - - NNS cord-005453-4057qib7 4997 36 responders responder NNS cord-005453-4057qib7 4997 37 succumbed succumb VBD cord-005453-4057qib7 4997 38 to to IN cord-005453-4057qib7 4997 39 GvHDrelated gvhdrelate VBN cord-005453-4057qib7 4997 40 infectious infectious JJ cord-005453-4057qib7 4997 41 complications complication NNS cord-005453-4057qib7 4997 42 . . . cord-005453-4057qib7 4998 1 The the DT cord-005453-4057qib7 4998 2 establishment establishment NN cord-005453-4057qib7 4998 3 of of IN cord-005453-4057qib7 4998 4 donors donor NNS cord-005453-4057qib7 4998 5 ' ' POS cord-005453-4057qib7 4998 6 microbiota microbiota NN cord-005453-4057qib7 4998 7 with with IN cord-005453-4057qib7 4998 8 the the DT cord-005453-4057qib7 4998 9 emergence emergence NN cord-005453-4057qib7 4998 10 of of IN cord-005453-4057qib7 4998 11 new new JJ cord-005453-4057qib7 4998 12 taxa taxon NNS cord-005453-4057qib7 4998 13 , , , cord-005453-4057qib7 4998 14 an an DT cord-005453-4057qib7 4998 15 increase increase NN cord-005453-4057qib7 4998 16 in in IN cord-005453-4057qib7 4998 17 bacterial bacterial JJ cord-005453-4057qib7 4998 18 richness richness NN cord-005453-4057qib7 4998 19 / / SYM cord-005453-4057qib7 4998 20 diversity diversity NN cord-005453-4057qib7 4998 21 , , , cord-005453-4057qib7 4998 22 and and CC cord-005453-4057qib7 4998 23 the the DT cord-005453-4057qib7 4998 24 disappearance disappearance NN cord-005453-4057qib7 4998 25 of of IN cord-005453-4057qib7 4998 26 the the DT cord-005453-4057qib7 4998 27 " " `` cord-005453-4057qib7 4998 28 enterococcus enterococcus NN cord-005453-4057qib7 4998 29 signature signature NN cord-005453-4057qib7 4998 30 " " '' cord-005453-4057qib7 4998 31 were be VBD cord-005453-4057qib7 4998 32 associated associate VBN cord-005453-4057qib7 4998 33 with with IN cord-005453-4057qib7 4998 34 disease disease NN cord-005453-4057qib7 4998 35 control control NN cord-005453-4057qib7 4998 36 and and CC cord-005453-4057qib7 4998 37 response response NN cord-005453-4057qib7 4998 38 to to IN cord-005453-4057qib7 4998 39 FMT FMT NNP cord-005453-4057qib7 4998 40 . . . cord-005453-4057qib7 4999 1 Except except IN cord-005453-4057qib7 4999 2 the the DT cord-005453-4057qib7 4999 3 possible possible JJ cord-005453-4057qib7 4999 4 transmission transmission NN cord-005453-4057qib7 4999 5 of of IN cord-005453-4057qib7 4999 6 Adenovirus Adenovirus NNP cord-005453-4057qib7 4999 7 by by IN cord-005453-4057qib7 4999 8 FMT FMT NNP cord-005453-4057qib7 4999 9 in in IN cord-005453-4057qib7 4999 10 one one CD cord-005453-4057qib7 4999 11 patient patient NN cord-005453-4057qib7 4999 12 , , , cord-005453-4057qib7 4999 13 no no DT cord-005453-4057qib7 4999 14 other other JJ cord-005453-4057qib7 4999 15 immediate immediate JJ cord-005453-4057qib7 4999 16 procedure procedure NN cord-005453-4057qib7 4999 17 - - HYPH cord-005453-4057qib7 4999 18 related relate VBN cord-005453-4057qib7 4999 19 infections infection NNS cord-005453-4057qib7 4999 20 or or CC cord-005453-4057qib7 4999 21 other other JJ cord-005453-4057qib7 4999 22 side side NN cord-005453-4057qib7 4999 23 effects effect NNS cord-005453-4057qib7 4999 24 were be VBD cord-005453-4057qib7 4999 25 observed observe VBN cord-005453-4057qib7 4999 26 . . . cord-005453-4057qib7 5000 1 Conclusions conclusion NNS cord-005453-4057qib7 5000 2 : : : cord-005453-4057qib7 5001 1 Restoration restoration NN cord-005453-4057qib7 5001 2 of of IN cord-005453-4057qib7 5001 3 dysbiosis dysbiosis NN cord-005453-4057qib7 5001 4 by by IN cord-005453-4057qib7 5001 5 FMT FMT NNP cord-005453-4057qib7 5001 6 might may MD cord-005453-4057qib7 5001 7 represent represent VB cord-005453-4057qib7 5001 8 a a DT cord-005453-4057qib7 5001 9 promising promising JJ cord-005453-4057qib7 5001 10 novel novel JJ cord-005453-4057qib7 5001 11 therapeutic therapeutic JJ cord-005453-4057qib7 5001 12 approach approach NN cord-005453-4057qib7 5001 13 for for IN cord-005453-4057qib7 5001 14 a a DT cord-005453-4057qib7 5001 15 subset subset NN cord-005453-4057qib7 5001 16 of of IN cord-005453-4057qib7 5001 17 patients patient NNS cord-005453-4057qib7 5001 18 with with IN cord-005453-4057qib7 5001 19 refractory refractory JJ cord-005453-4057qib7 5001 20 lower low JJR cord-005453-4057qib7 5001 21 GI GI NNP cord-005453-4057qib7 5001 22 - - HYPH cord-005453-4057qib7 5001 23 aGvHD agvhd NN cord-005453-4057qib7 5001 24 . . . cord-005453-4057qib7 5002 1 Vigorous vigorous JJ cord-005453-4057qib7 5002 2 donor donor NN cord-005453-4057qib7 5002 3 screening screening NN cord-005453-4057qib7 5002 4 for for IN cord-005453-4057qib7 5002 5 infectious infectious JJ cord-005453-4057qib7 5002 6 disease disease NN cord-005453-4057qib7 5002 7 is be VBZ cord-005453-4057qib7 5002 8 mandatory mandatory JJ cord-005453-4057qib7 5002 9 . . . cord-005453-4057qib7 5003 1 Clinical clinical JJ cord-005453-4057qib7 5003 2 Background background NN cord-005453-4057qib7 5003 3 : : : cord-005453-4057qib7 5004 1 Migration migration NN cord-005453-4057qib7 5004 2 of of IN cord-005453-4057qib7 5004 3 allo allo NN cord-005453-4057qib7 5004 4 - - HYPH cord-005453-4057qib7 5004 5 activated activate VBN cord-005453-4057qib7 5004 6 donor donor NN cord-005453-4057qib7 5004 7 effector effector NN cord-005453-4057qib7 5004 8 Tcells Tcells NNP cord-005453-4057qib7 5004 9 from from IN cord-005453-4057qib7 5004 10 lymphoid lymphoid JJ cord-005453-4057qib7 5004 11 tissues tissue NNS cord-005453-4057qib7 5004 12 to to TO cord-005453-4057qib7 5004 13 target target VB cord-005453-4057qib7 5004 14 organs organ NNS cord-005453-4057qib7 5004 15 is be VBZ cord-005453-4057qib7 5004 16 an an DT cord-005453-4057qib7 5004 17 important important JJ cord-005453-4057qib7 5004 18 step step NN cord-005453-4057qib7 5004 19 in in IN cord-005453-4057qib7 5004 20 acute acute JJ cord-005453-4057qib7 5004 21 graft graft NN cord-005453-4057qib7 5004 22 versus versus IN cord-005453-4057qib7 5004 23 host host NN cord-005453-4057qib7 5004 24 disease disease NN cord-005453-4057qib7 5004 25 ( ( -LRB- cord-005453-4057qib7 5004 26 GvHD GvHD NNP cord-005453-4057qib7 5004 27 ) ) -RRB- cord-005453-4057qib7 5004 28 . . . cord-005453-4057qib7 5005 1 The the DT cord-005453-4057qib7 5005 2 sphingosine-1-phosphate-1 sphingosine-1-phosphate-1 NNP cord-005453-4057qib7 5005 3 ( ( -LRB- cord-005453-4057qib7 5005 4 S1P1 S1P1 NNP cord-005453-4057qib7 5005 5 ) ) -RRB- cord-005453-4057qib7 5005 6 receptor receptor NN cord-005453-4057qib7 5005 7 plays play VBZ cord-005453-4057qib7 5005 8 a a DT cord-005453-4057qib7 5005 9 crucial crucial JJ cord-005453-4057qib7 5005 10 role role NN cord-005453-4057qib7 5005 11 in in IN cord-005453-4057qib7 5005 12 lymphocyte lymphocyte NN cord-005453-4057qib7 5005 13 trafficking trafficking NN cord-005453-4057qib7 5005 14 . . . cord-005453-4057qib7 5006 1 Data datum NNS cord-005453-4057qib7 5006 2 from from IN cord-005453-4057qib7 5006 3 animal animal NN cord-005453-4057qib7 5006 4 models model NNS cord-005453-4057qib7 5006 5 suggest suggest VBP cord-005453-4057qib7 5006 6 that that IN cord-005453-4057qib7 5006 7 pharmacological pharmacological JJ cord-005453-4057qib7 5006 8 modulation modulation NN cord-005453-4057qib7 5006 9 of of IN cord-005453-4057qib7 5006 10 the the DT cord-005453-4057qib7 5006 11 S1P1 S1P1 NNP cord-005453-4057qib7 5006 12 receptor receptor NN cord-005453-4057qib7 5006 13 reduces reduce VBZ cord-005453-4057qib7 5006 14 GvHD GvHD NNP cord-005453-4057qib7 5006 15 and and CC cord-005453-4057qib7 5006 16 improves improve VBZ cord-005453-4057qib7 5006 17 mortality mortality NN cord-005453-4057qib7 5006 18 . . . cord-005453-4057qib7 5007 1 We -PRON- PRP cord-005453-4057qib7 5007 2 investigated investigate VBD cord-005453-4057qib7 5007 3 this this DT cord-005453-4057qib7 5007 4 mode mode NN cord-005453-4057qib7 5007 5 of of IN cord-005453-4057qib7 5007 6 action action NN cord-005453-4057qib7 5007 7 by by IN cord-005453-4057qib7 5007 8 using use VBG cord-005453-4057qib7 5007 9 the the DT cord-005453-4057qib7 5007 10 secondgeneration secondgeneration NN cord-005453-4057qib7 5007 11 S1P1 S1P1 NNP cord-005453-4057qib7 5007 12 modulator modulator NN cord-005453-4057qib7 5007 13 KRP203 krp203 NN cord-005453-4057qib7 5007 14 for for IN cord-005453-4057qib7 5007 15 the the DT cord-005453-4057qib7 5007 16 prophylaxis prophylaxis NN cord-005453-4057qib7 5007 17 of of IN cord-005453-4057qib7 5007 18 GvHD GvHD NNP cord-005453-4057qib7 5007 19 in in IN cord-005453-4057qib7 5007 20 a a DT cord-005453-4057qib7 5007 21 pilot pilot NN cord-005453-4057qib7 5007 22 clinical clinical JJ cord-005453-4057qib7 5007 23 trial trial NN cord-005453-4057qib7 5007 24 in in IN cord-005453-4057qib7 5007 25 patients patient NNS cord-005453-4057qib7 5007 26 undergoing undergo VBG cord-005453-4057qib7 5007 27 allogeneic allogeneic IN cord-005453-4057qib7 5007 28 HSCT HSCT NNP cord-005453-4057qib7 5007 29 . . . cord-005453-4057qib7 5008 1 Methods method NNS cord-005453-4057qib7 5008 2 : : : cord-005453-4057qib7 5009 1 A a DT cord-005453-4057qib7 5009 2 multi multi JJ cord-005453-4057qib7 5009 3 - - JJ cord-005453-4057qib7 5009 4 centric centric JJ cord-005453-4057qib7 5009 5 , , , cord-005453-4057qib7 5009 6 Phase phase NN cord-005453-4057qib7 5009 7 1b 1b CD cord-005453-4057qib7 5009 8 , , , cord-005453-4057qib7 5009 9 prospective prospective JJ cord-005453-4057qib7 5009 10 , , , cord-005453-4057qib7 5009 11 open open JJ cord-005453-4057qib7 5009 12 label label NN cord-005453-4057qib7 5009 13 , , , cord-005453-4057qib7 5009 14 two two CD cord-005453-4057qib7 5009 15 - - HYPH cord-005453-4057qib7 5009 16 part part NN cord-005453-4057qib7 5009 17 study study NN cord-005453-4057qib7 5009 18 was be VBD cord-005453-4057qib7 5009 19 conducted conduct VBN cord-005453-4057qib7 5009 20 to to TO cord-005453-4057qib7 5009 21 evaluate evaluate VB cord-005453-4057qib7 5009 22 the the DT cord-005453-4057qib7 5009 23 safety safety NN cord-005453-4057qib7 5009 24 , , , cord-005453-4057qib7 5009 25 tolerability tolerability NN cord-005453-4057qib7 5009 26 and and CC cord-005453-4057qib7 5009 27 pharmacokinetics pharmacokinetic NNS cord-005453-4057qib7 5009 28 of of IN cord-005453-4057qib7 5009 29 KRP203 krp203 DT cord-005453-4057qib7 5009 30 in in IN cord-005453-4057qib7 5009 31 patients patient NNS cord-005453-4057qib7 5009 32 undergoing undergo VBG cord-005453-4057qib7 5009 33 allogeneic allogeneic IN cord-005453-4057qib7 5009 34 HSCT HSCT NNP cord-005453-4057qib7 5009 35 for for IN cord-005453-4057qib7 5009 36 hematological hematological JJ cord-005453-4057qib7 5009 37 malignancies malignancy NNS cord-005453-4057qib7 5009 38 . . . cord-005453-4057qib7 5010 1 Primary primary JJ cord-005453-4057qib7 5010 2 endpoint endpoint NN cord-005453-4057qib7 5010 3 was be VBD cord-005453-4057qib7 5010 4 safety safety NN cord-005453-4057qib7 5010 5 . . . cord-005453-4057qib7 5011 1 Initial initial JJ cord-005453-4057qib7 5011 2 efficacy efficacy NN cord-005453-4057qib7 5011 3 was be VBD cord-005453-4057qib7 5011 4 explored explore VBN cord-005453-4057qib7 5011 5 based base VBN cord-005453-4057qib7 5011 6 on on IN cord-005453-4057qib7 5011 7 the the DT cord-005453-4057qib7 5011 8 incidence incidence NN cord-005453-4057qib7 5011 9 of of IN cord-005453-4057qib7 5011 10 GvHD gvhd NN cord-005453-4057qib7 5011 11 , , , cord-005453-4057qib7 5011 12 mortality mortality NN cord-005453-4057qib7 5011 13 and and CC cord-005453-4057qib7 5011 14 relapse relapse NN cord-005453-4057qib7 5011 15 . . . cord-005453-4057qib7 5012 1 Part part NN cord-005453-4057qib7 5012 2 1 1 CD cord-005453-4057qib7 5012 3 was be VBD cord-005453-4057qib7 5012 4 a a DT cord-005453-4057qib7 5012 5 single single JJ cord-005453-4057qib7 5012 6 arm arm NN cord-005453-4057qib7 5012 7 open open JJ cord-005453-4057qib7 5012 8 label label NN cord-005453-4057qib7 5012 9 study study NN cord-005453-4057qib7 5012 10 to to TO cord-005453-4057qib7 5012 11 investigate investigate VB cord-005453-4057qib7 5012 12 the the DT cord-005453-4057qib7 5012 13 safety safety NN cord-005453-4057qib7 5012 14 of of IN cord-005453-4057qib7 5012 15 3 3 CD cord-005453-4057qib7 5012 16 mg mg NNP cord-005453-4057qib7 5012 17 / / SYM cord-005453-4057qib7 5012 18 day day NN cord-005453-4057qib7 5012 19 KRP203 KRP203 NNP cord-005453-4057qib7 5012 20 added add VBD cord-005453-4057qib7 5012 21 to to IN cord-005453-4057qib7 5012 22 standard standard NN cord-005453-4057qib7 5012 23 of of IN cord-005453-4057qib7 5012 24 care care NN cord-005453-4057qib7 5012 25 GvHD GvHD NNP cord-005453-4057qib7 5012 26 prophylaxis prophylaxis NN cord-005453-4057qib7 5012 27 ( ( -LRB- cord-005453-4057qib7 5012 28 CsA CsA NNP cord-005453-4057qib7 5012 29 / / SYM cord-005453-4057qib7 5012 30 MTX MTX NNP cord-005453-4057qib7 5012 31 ) ) -RRB- cord-005453-4057qib7 5012 32 in in IN cord-005453-4057qib7 5012 33 10 10 CD cord-005453-4057qib7 5012 34 patients patient NNS cord-005453-4057qib7 5012 35 . . . cord-005453-4057qib7 5013 1 Part part NN cord-005453-4057qib7 5013 2 2 2 CD cord-005453-4057qib7 5013 3 was be VBD cord-005453-4057qib7 5013 4 a a DT cord-005453-4057qib7 5013 5 randomized randomized JJ cord-005453-4057qib7 5013 6 two two CD cord-005453-4057qib7 5013 7 - - HYPH cord-005453-4057qib7 5013 8 arm arm NN cord-005453-4057qib7 5013 9 open open JJ cord-005453-4057qib7 5013 10 label label NN cord-005453-4057qib7 5013 11 study study NN cord-005453-4057qib7 5013 12 to to TO cord-005453-4057qib7 5013 13 compare compare VB cord-005453-4057qib7 5013 14 the the DT cord-005453-4057qib7 5013 15 safety safety NN cord-005453-4057qib7 5013 16 , , , cord-005453-4057qib7 5013 17 efficacy efficacy NN cord-005453-4057qib7 5013 18 and and CC cord-005453-4057qib7 5013 19 PK PK NNP cord-005453-4057qib7 5013 20 of of IN cord-005453-4057qib7 5013 21 3 3 CD cord-005453-4057qib7 5013 22 mg mg NNP cord-005453-4057qib7 5013 23 / / SYM cord-005453-4057qib7 5013 24 day day NN cord-005453-4057qib7 5013 25 of of IN cord-005453-4057qib7 5013 26 KRP203 KRP203 NNP cord-005453-4057qib7 5013 27 in in IN cord-005453-4057qib7 5013 28 combination combination NN cord-005453-4057qib7 5013 29 with with IN cord-005453-4057qib7 5013 30 tacrolimus tacrolimus NNP cord-005453-4057qib7 5013 31 / / SYM cord-005453-4057qib7 5013 32 MTX MTX NNP cord-005453-4057qib7 5013 33 to to IN cord-005453-4057qib7 5013 34 1 1 CD cord-005453-4057qib7 5013 35 mg mg CD cord-005453-4057qib7 5013 36 / / SYM cord-005453-4057qib7 5013 37 day day NN cord-005453-4057qib7 5013 38 of of IN cord-005453-4057qib7 5013 39 KRP203 KRP203 NNP cord-005453-4057qib7 5013 40 in in IN cord-005453-4057qib7 5013 41 combination combination NN cord-005453-4057qib7 5013 42 with with IN cord-005453-4057qib7 5013 43 CsA CsA NNP cord-005453-4057qib7 5013 44 / / SYM cord-005453-4057qib7 5013 45 MTX MTX NNP cord-005453-4057qib7 5013 46 in in IN cord-005453-4057qib7 5013 47 13 13 CD cord-005453-4057qib7 5013 48 patients patient NNS cord-005453-4057qib7 5013 49 . . . cord-005453-4057qib7 5014 1 In in IN cord-005453-4057qib7 5014 2 both both DT cord-005453-4057qib7 5014 3 parts part NNS cord-005453-4057qib7 5014 4 , , , cord-005453-4057qib7 5014 5 treatment treatment NN cord-005453-4057qib7 5014 6 with with IN cord-005453-4057qib7 5014 7 KRP203 KRP203 NNP cord-005453-4057qib7 5014 8 was be VBD cord-005453-4057qib7 5014 9 initiated initiate VBN cord-005453-4057qib7 5014 10 10 10 CD cord-005453-4057qib7 5014 11 days day NNS cord-005453-4057qib7 5014 12 before before IN cord-005453-4057qib7 5014 13 HSCT HSCT NNP cord-005453-4057qib7 5014 14 and and CC cord-005453-4057qib7 5014 15 continued continue VBD cord-005453-4057qib7 5014 16 for for IN cord-005453-4057qib7 5014 17 an an DT cord-005453-4057qib7 5014 18 additional additional JJ cord-005453-4057qib7 5014 19 100 100 CD cord-005453-4057qib7 5014 20 days day NNS cord-005453-4057qib7 5014 21 . . . cord-005453-4057qib7 5015 1 Patients patient NNS cord-005453-4057qib7 5015 2 were be VBD cord-005453-4057qib7 5015 3 followed follow VBN cord-005453-4057qib7 5015 4 up up RP cord-005453-4057qib7 5015 5 for for IN cord-005453-4057qib7 5015 6 up up IN cord-005453-4057qib7 5015 7 to to TO cord-005453-4057qib7 5015 8 2 2 CD cord-005453-4057qib7 5015 9 years year NNS cord-005453-4057qib7 5015 10 . . . cord-005453-4057qib7 5016 1 Results result NNS cord-005453-4057qib7 5016 2 : : : cord-005453-4057qib7 5016 3 23 23 CD cord-005453-4057qib7 5016 4 patients patient NNS cord-005453-4057qib7 5016 5 were be VBD cord-005453-4057qib7 5016 6 included include VBN cord-005453-4057qib7 5016 7 in in IN cord-005453-4057qib7 5016 8 the the DT cord-005453-4057qib7 5016 9 study study NN cord-005453-4057qib7 5016 10 . . . cord-005453-4057qib7 5017 1 16 16 CD cord-005453-4057qib7 5017 2 of of IN cord-005453-4057qib7 5017 3 23 23 CD cord-005453-4057qib7 5017 4 patients patient NNS cord-005453-4057qib7 5017 5 completed complete VBD cord-005453-4057qib7 5017 6 the the DT cord-005453-4057qib7 5017 7 110-day 110-day CD cord-005453-4057qib7 5017 8 treatment treatment NN cord-005453-4057qib7 5017 9 with with IN cord-005453-4057qib7 5017 10 KRP203 KRP203 NNP cord-005453-4057qib7 5017 11 at at IN cord-005453-4057qib7 5017 12 the the DT cord-005453-4057qib7 5017 13 assigned assign VBN cord-005453-4057qib7 5017 14 doses dose NNS cord-005453-4057qib7 5017 15 . . . cord-005453-4057qib7 5018 1 Median median JJ cord-005453-4057qib7 5018 2 duration duration NN cord-005453-4057qib7 5018 3 of of IN cord-005453-4057qib7 5018 4 follow follow NN cord-005453-4057qib7 5018 5 - - HYPH cord-005453-4057qib7 5018 6 up up NN cord-005453-4057qib7 5018 7 was be VBD cord-005453-4057qib7 5018 8 264 264 CD cord-005453-4057qib7 5018 9 days day NNS cord-005453-4057qib7 5018 10 ( ( -LRB- cord-005453-4057qib7 5018 11 range range VBP cord-005453-4057qib7 5018 12 153 153 CD cord-005453-4057qib7 5018 13 to to TO cord-005453-4057qib7 5018 14 271 271 CD cord-005453-4057qib7 5018 15 days day NNS cord-005453-4057qib7 5018 16 ) ) -RRB- cord-005453-4057qib7 5018 17 . . . cord-005453-4057qib7 5019 1 KRP203 KRP203 NNP cord-005453-4057qib7 5019 2 was be VBD cord-005453-4057qib7 5019 3 safe safe JJ cord-005453-4057qib7 5019 4 and and CC cord-005453-4057qib7 5019 5 well well RB cord-005453-4057qib7 5019 6 tolerated tolerate VBN cord-005453-4057qib7 5019 7 . . . cord-005453-4057qib7 5020 1 11 11 CD cord-005453-4057qib7 5020 2 serious serious JJ cord-005453-4057qib7 5020 3 adverse adverse JJ cord-005453-4057qib7 5020 4 events event NNS cord-005453-4057qib7 5020 5 ( ( -LRB- cord-005453-4057qib7 5020 6 SAEs SAEs NNP cord-005453-4057qib7 5020 7 ) ) -RRB- cord-005453-4057qib7 5020 8 suspected suspect VBN cord-005453-4057qib7 5020 9 to to TO cord-005453-4057qib7 5020 10 be be VB cord-005453-4057qib7 5020 11 related relate VBN cord-005453-4057qib7 5020 12 to to IN cord-005453-4057qib7 5020 13 KRP203 KRP203 NNP cord-005453-4057qib7 5020 14 were be VBD cord-005453-4057qib7 5020 15 observed observe VBN cord-005453-4057qib7 5020 16 . . . cord-005453-4057qib7 5021 1 Macular macular JJ cord-005453-4057qib7 5021 2 edema edema NN cord-005453-4057qib7 5021 3 ( ( -LRB- cord-005453-4057qib7 5021 4 n=3 n=3 NN cord-005453-4057qib7 5021 5 ) ) -RRB- cord-005453-4057qib7 5021 6 and and CC cord-005453-4057qib7 5021 7 peripheral peripheral JJ cord-005453-4057qib7 5021 8 edema edema NN cord-005453-4057qib7 5021 9 ( ( -LRB- cord-005453-4057qib7 5021 10 n=1 n=1 FW cord-005453-4057qib7 5021 11 ) ) -RRB- cord-005453-4057qib7 5022 1 as as IN cord-005453-4057qib7 5022 2 S1P s1p CD cord-005453-4057qib7 5022 3 related relate VBN cord-005453-4057qib7 5022 4 adverse adverse JJ cord-005453-4057qib7 5022 5 events event NNS cord-005453-4057qib7 5022 6 occurred occur VBD cord-005453-4057qib7 5022 7 and and CC cord-005453-4057qib7 5022 8 resolved resolve VBD cord-005453-4057qib7 5022 9 without without IN cord-005453-4057qib7 5022 10 sequelae sequela NNS cord-005453-4057qib7 5022 11 . . . cord-005453-4057qib7 5023 1 Of of IN cord-005453-4057qib7 5023 2 note note NN cord-005453-4057qib7 5023 3 , , , cord-005453-4057qib7 5023 4 the the DT cord-005453-4057qib7 5023 5 incidence incidence NN cord-005453-4057qib7 5023 6 of of IN cord-005453-4057qib7 5023 7 macular macular JJ cord-005453-4057qib7 5023 8 edema edema NN cord-005453-4057qib7 5023 9 in in IN cord-005453-4057qib7 5023 10 HSCT HSCT NNP cord-005453-4057qib7 5023 11 recipients recipient NNS cord-005453-4057qib7 5023 12 is be VBZ cord-005453-4057qib7 5023 13 unknown unknown JJ cord-005453-4057qib7 5023 14 . . . cord-005453-4057qib7 5024 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 5024 2 engraftment engraftment NN cord-005453-4057qib7 5024 3 was be VBD cord-005453-4057qib7 5024 4 confirmed confirm VBN cord-005453-4057qib7 5024 5 in in IN cord-005453-4057qib7 5024 6 all all DT cord-005453-4057qib7 5024 7 patients patient NNS cord-005453-4057qib7 5024 8 with with IN cord-005453-4057qib7 5024 9 a a DT cord-005453-4057qib7 5024 10 median median NN cord-005453-4057qib7 5024 11 of of IN cord-005453-4057qib7 5024 12 16 16 CD cord-005453-4057qib7 5024 13 days day NNS cord-005453-4057qib7 5024 14 ( ( -LRB- cord-005453-4057qib7 5024 15 range range VBP cord-005453-4057qib7 5024 16 12 12 CD cord-005453-4057qib7 5024 17 to to TO cord-005453-4057qib7 5024 18 45 45 CD cord-005453-4057qib7 5024 19 days day NNS cord-005453-4057qib7 5024 20 ) ) -RRB- cord-005453-4057qib7 5024 21 . . . cord-005453-4057qib7 5025 1 5 5 CD cord-005453-4057qib7 5025 2 of of IN cord-005453-4057qib7 5025 3 23 23 CD cord-005453-4057qib7 5025 4 patients patient NNS cord-005453-4057qib7 5025 5 presented present VBN cord-005453-4057qib7 5025 6 with with IN cord-005453-4057qib7 5025 7 Grade Grade NNP cord-005453-4057qib7 5025 8 III III NNP cord-005453-4057qib7 5025 9 or or CC cord-005453-4057qib7 5025 10 IV IV NNP cord-005453-4057qib7 5025 11 acute acute JJ cord-005453-4057qib7 5025 12 GvHD GvHD NNP cord-005453-4057qib7 5025 13 ( ( -LRB- cord-005453-4057qib7 5025 14 on on IN cord-005453-4057qib7 5025 15 Days day NNS cord-005453-4057qib7 5025 16 50 50 CD cord-005453-4057qib7 5025 17 , , , cord-005453-4057qib7 5025 18 56 56 CD cord-005453-4057qib7 5025 19 , , , cord-005453-4057qib7 5025 20 68 68 CD cord-005453-4057qib7 5025 21 , , , cord-005453-4057qib7 5025 22 99 99 CD cord-005453-4057qib7 5025 23 and and CC cord-005453-4057qib7 5025 24 102 102 CD cord-005453-4057qib7 5025 25 ) ) -RRB- cord-005453-4057qib7 5025 26 . . . cord-005453-4057qib7 5026 1 No no DT cord-005453-4057qib7 5026 2 GvHD gvhd NN cord-005453-4057qib7 5026 3 or or CC cord-005453-4057qib7 5026 4 infection infection NN cord-005453-4057qib7 5026 5 related relate VBN cord-005453-4057qib7 5026 6 death death NN cord-005453-4057qib7 5026 7 occurred occur VBD cord-005453-4057qib7 5026 8 during during IN cord-005453-4057qib7 5026 9 the the DT cord-005453-4057qib7 5026 10 first first JJ cord-005453-4057qib7 5026 11 100 100 CD cord-005453-4057qib7 5026 12 days day NNS cord-005453-4057qib7 5026 13 . . . cord-005453-4057qib7 5027 1 100-day 100-day JJ cord-005453-4057qib7 5027 2 survival survival NN cord-005453-4057qib7 5027 3 was be VBD cord-005453-4057qib7 5027 4 96 96 CD cord-005453-4057qib7 5027 5 % % NN cord-005453-4057qib7 5027 6 , , , cord-005453-4057qib7 5027 7 with with IN cord-005453-4057qib7 5027 8 no no DT cord-005453-4057qib7 5027 9 death death NN cord-005453-4057qib7 5027 10 occurring occur VBG cord-005453-4057qib7 5027 11 during during IN cord-005453-4057qib7 5027 12 KRP203 krp203 DT cord-005453-4057qib7 5027 13 treatment treatment NN cord-005453-4057qib7 5027 14 . . . cord-005453-4057qib7 5028 1 1 1 CD cord-005453-4057qib7 5028 2 death death NN cord-005453-4057qib7 5028 3 occurred occur VBD cord-005453-4057qib7 5028 4 on on IN cord-005453-4057qib7 5028 5 Study Study NNP cord-005453-4057qib7 5028 6 Day Day NNP cord-005453-4057qib7 5028 7 90 90 CD cord-005453-4057qib7 5028 8 due due IN cord-005453-4057qib7 5028 9 to to IN cord-005453-4057qib7 5028 10 lymphoma lymphoma NN cord-005453-4057qib7 5028 11 relapse relapse NN cord-005453-4057qib7 5028 12 . . . cord-005453-4057qib7 5029 1 A a DT cord-005453-4057qib7 5029 2 second second JJ cord-005453-4057qib7 5029 3 death death NN cord-005453-4057qib7 5029 4 occurred occur VBD cord-005453-4057qib7 5029 5 on on IN cord-005453-4057qib7 5029 6 Study Study NNP cord-005453-4057qib7 5029 7 Day Day NNP cord-005453-4057qib7 5029 8 121 121 CD cord-005453-4057qib7 5029 9 due due JJ cord-005453-4057qib7 5029 10 to to IN cord-005453-4057qib7 5029 11 liver liver NN cord-005453-4057qib7 5029 12 GvHD GvHD NNP cord-005453-4057qib7 5029 13 . . . cord-005453-4057qib7 5030 1 Four four CD cord-005453-4057qib7 5030 2 patients patient NNS cord-005453-4057qib7 5030 3 died die VBD cord-005453-4057qib7 5030 4 in in IN cord-005453-4057qib7 5030 5 the the DT cord-005453-4057qib7 5030 6 follow follow VB cord-005453-4057qib7 5030 7 - - HYPH cord-005453-4057qib7 5030 8 up up NN cord-005453-4057qib7 5030 9 period period NN cord-005453-4057qib7 5030 10 due due IN cord-005453-4057qib7 5030 11 to to IN cord-005453-4057qib7 5030 12 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 5030 13 GVHD GVHD NNP cord-005453-4057qib7 5030 14 ( ( -LRB- cord-005453-4057qib7 5030 15 Day Day NNP cord-005453-4057qib7 5030 16 265 265 CD cord-005453-4057qib7 5030 17 ) ) -RRB- cord-005453-4057qib7 5030 18 , , , cord-005453-4057qib7 5030 19 aspiration aspiration NN cord-005453-4057qib7 5030 20 pneumonia pneumonia NN cord-005453-4057qib7 5030 21 ( ( -LRB- cord-005453-4057qib7 5030 22 Day Day NNP cord-005453-4057qib7 5030 23 327 327 CD cord-005453-4057qib7 5030 24 ) ) -RRB- cord-005453-4057qib7 5030 25 and and CC cord-005453-4057qib7 5030 26 relapse relapse NN cord-005453-4057qib7 5030 27 ( ( -LRB- cord-005453-4057qib7 5030 28 Day day NN cord-005453-4057qib7 5030 29 533 533 CD cord-005453-4057qib7 5030 30 and and CC cord-005453-4057qib7 5030 31 Day Day NNP cord-005453-4057qib7 5030 32 877 877 CD cord-005453-4057qib7 5030 33 ) ) -RRB- cord-005453-4057qib7 5030 34 . . . cord-005453-4057qib7 5031 1 The the DT cord-005453-4057qib7 5031 2 Kaplan Kaplan NNP cord-005453-4057qib7 5031 3 - - HYPH cord-005453-4057qib7 5031 4 Meier Meier NNP cord-005453-4057qib7 5031 5 estimate estimate NN cord-005453-4057qib7 5031 6 of of IN cord-005453-4057qib7 5031 7 overall overall JJ cord-005453-4057qib7 5031 8 survival survival NN cord-005453-4057qib7 5031 9 at at IN cord-005453-4057qib7 5031 10 1 1 CD cord-005453-4057qib7 5031 11 year year NN cord-005453-4057qib7 5031 12 was be VBD cord-005453-4057qib7 5031 13 0.75 0.75 CD cord-005453-4057qib7 5031 14 . . . cord-005453-4057qib7 5032 1 When when WRB cord-005453-4057qib7 5032 2 comparing compare VBG cord-005453-4057qib7 5032 3 the the DT cord-005453-4057qib7 5032 4 data datum NNS cord-005453-4057qib7 5032 5 from from IN cord-005453-4057qib7 5032 6 the the DT cord-005453-4057qib7 5032 7 two two CD cord-005453-4057qib7 5032 8 dose dose NN cord-005453-4057qib7 5032 9 groups group NNS cord-005453-4057qib7 5032 10 ( ( -LRB- cord-005453-4057qib7 5032 11 1 1 CD cord-005453-4057qib7 5032 12 and and CC cord-005453-4057qib7 5032 13 3 3 CD cord-005453-4057qib7 5032 14 mg mg NN cord-005453-4057qib7 5032 15 KRP203 KRP203 NNP cord-005453-4057qib7 5032 16 ) ) -RRB- cord-005453-4057qib7 5032 17 , , , cord-005453-4057qib7 5032 18 no no DT cord-005453-4057qib7 5032 19 major major JJ cord-005453-4057qib7 5032 20 differences difference NNS cord-005453-4057qib7 5032 21 in in IN cord-005453-4057qib7 5032 22 safety safety NN cord-005453-4057qib7 5032 23 , , , cord-005453-4057qib7 5032 24 engraftment engraftment NN cord-005453-4057qib7 5032 25 , , , cord-005453-4057qib7 5032 26 GvHD gvhd JJ cord-005453-4057qib7 5032 27 rate rate NN cord-005453-4057qib7 5032 28 or or CC cord-005453-4057qib7 5032 29 mortality mortality NN cord-005453-4057qib7 5032 30 were be VBD cord-005453-4057qib7 5032 31 observed observe VBN cord-005453-4057qib7 5032 32 . . . cord-005453-4057qib7 5033 1 Conclusions conclusion NNS cord-005453-4057qib7 5033 2 : : : cord-005453-4057qib7 5034 1 This this DT cord-005453-4057qib7 5034 2 clinical clinical JJ cord-005453-4057qib7 5034 3 trial trial NN cord-005453-4057qib7 5034 4 was be VBD cord-005453-4057qib7 5034 5 the the DT cord-005453-4057qib7 5034 6 first first JJ cord-005453-4057qib7 5034 7 to to TO cord-005453-4057qib7 5034 8 test test VB cord-005453-4057qib7 5034 9 S1P s1p CD cord-005453-4057qib7 5034 10 modulation modulation NN cord-005453-4057qib7 5034 11 in in IN cord-005453-4057qib7 5034 12 this this DT cord-005453-4057qib7 5034 13 population population NN cord-005453-4057qib7 5034 14 . . . cord-005453-4057qib7 5035 1 Our -PRON- PRP$ cord-005453-4057qib7 5035 2 data datum NNS cord-005453-4057qib7 5035 3 suggest suggest VBP cord-005453-4057qib7 5035 4 that that IN cord-005453-4057qib7 5035 5 KRP203 KRP203 NNP cord-005453-4057qib7 5035 6 had have VBD cord-005453-4057qib7 5035 7 no no DT cord-005453-4057qib7 5035 8 negative negative JJ cord-005453-4057qib7 5035 9 impact impact NN cord-005453-4057qib7 5035 10 on on IN cord-005453-4057qib7 5035 11 engraftment engraftment NN cord-005453-4057qib7 5035 12 and and CC cord-005453-4057qib7 5035 13 overall overall RB cord-005453-4057qib7 5035 14 , , , cord-005453-4057qib7 5035 15 was be VBD cord-005453-4057qib7 5035 16 safe safe JJ cord-005453-4057qib7 5035 17 , , , cord-005453-4057qib7 5035 18 and and CC cord-005453-4057qib7 5035 19 well well RB cord-005453-4057qib7 5035 20 tolerated tolerate VBN cord-005453-4057qib7 5035 21 . . . cord-005453-4057qib7 5036 1 Based base VBN cord-005453-4057qib7 5036 2 on on IN cord-005453-4057qib7 5036 3 exploratory exploratory JJ cord-005453-4057qib7 5036 4 data datum NNS cord-005453-4057qib7 5036 5 , , , cord-005453-4057qib7 5036 6 when when WRB cord-005453-4057qib7 5036 7 comparing compare VBG cord-005453-4057qib7 5036 8 to to IN cord-005453-4057qib7 5036 9 matched match VBN cord-005453-4057qib7 5036 10 historical historical JJ cord-005453-4057qib7 5036 11 mortality mortality NN cord-005453-4057qib7 5036 12 data datum NNS cord-005453-4057qib7 5036 13 , , , cord-005453-4057qib7 5036 14 KRP203 KRP203 NNP cord-005453-4057qib7 5036 15 may may MD cord-005453-4057qib7 5036 16 have have VB cord-005453-4057qib7 5036 17 favorable favorable JJ cord-005453-4057qib7 5036 18 effects effect NNS cord-005453-4057qib7 5036 19 on on IN cord-005453-4057qib7 5036 20 overall overall JJ cord-005453-4057qib7 5036 21 survival survival NN cord-005453-4057qib7 5036 22 ( ( -LRB- cord-005453-4057qib7 5036 23 Figure figure NN cord-005453-4057qib7 5036 24 1 1 CD cord-005453-4057qib7 5036 25 ) ) -RRB- cord-005453-4057qib7 5036 26 . . . cord-005453-4057qib7 5037 1 Background background NN cord-005453-4057qib7 5037 2 : : : cord-005453-4057qib7 5038 1 Uric uric JJ cord-005453-4057qib7 5038 2 acid acid NN cord-005453-4057qib7 5038 3 is be VBZ cord-005453-4057qib7 5038 4 a a DT cord-005453-4057qib7 5038 5 danger danger NN cord-005453-4057qib7 5038 6 signal signal NN cord-005453-4057qib7 5038 7 contributing contribute VBG cord-005453-4057qib7 5038 8 to to IN cord-005453-4057qib7 5038 9 inflammation inflammation NN cord-005453-4057qib7 5038 10 . . . cord-005453-4057qib7 5039 1 Relevance relevance NN cord-005453-4057qib7 5039 2 to to IN cord-005453-4057qib7 5039 3 alloSCT alloSCT NNP cord-005453-4057qib7 5039 4 has have VBZ cord-005453-4057qib7 5039 5 been be VBN cord-005453-4057qib7 5039 6 demonstrated demonstrate VBN cord-005453-4057qib7 5039 7 in in IN cord-005453-4057qib7 5039 8 preclinical preclinical JJ cord-005453-4057qib7 5039 9 models model NNS cord-005453-4057qib7 5039 10 : : : cord-005453-4057qib7 5039 11 the the DT cord-005453-4057qib7 5039 12 depletion depletion NN cord-005453-4057qib7 5039 13 of of IN cord-005453-4057qib7 5039 14 uric uric NN cord-005453-4057qib7 5039 15 acid acid NN cord-005453-4057qib7 5039 16 led lead VBD cord-005453-4057qib7 5039 17 to to IN cord-005453-4057qib7 5039 18 improved improve VBN cord-005453-4057qib7 5039 19 survival survival NN cord-005453-4057qib7 5039 20 and and CC cord-005453-4057qib7 5039 21 reduced reduce VBN cord-005453-4057qib7 5039 22 GVHD GVHD NNP cord-005453-4057qib7 5039 23 ( ( -LRB- cord-005453-4057qib7 5039 24 J J NNP cord-005453-4057qib7 5039 25 Exp Exp NNP cord-005453-4057qib7 5039 26 Med Med NNP cord-005453-4057qib7 5039 27 . . . cord-005453-4057qib7 5039 28 2013 2013 CD cord-005453-4057qib7 5039 29 Sep Sep NNP cord-005453-4057qib7 5039 30 23;210(10):1899 23;210(10):1899 CD cord-005453-4057qib7 5039 31 - - SYM cord-005453-4057qib7 5039 32 910 910 CD cord-005453-4057qib7 5039 33 ) ) -RRB- cord-005453-4057qib7 5039 34 . . . cord-005453-4057qib7 5040 1 Results result NNS cord-005453-4057qib7 5040 2 of of IN cord-005453-4057qib7 5040 3 a a DT cord-005453-4057qib7 5040 4 clinical clinical JJ cord-005453-4057qib7 5040 5 pilot pilot NN cord-005453-4057qib7 5040 6 trial trial NN cord-005453-4057qib7 5040 7 suggested suggest VBD cord-005453-4057qib7 5040 8 that that IN cord-005453-4057qib7 5040 9 peri peri NN cord-005453-4057qib7 5040 10 - - HYPH cord-005453-4057qib7 5040 11 transplant transplant NN cord-005453-4057qib7 5040 12 uric uric NN cord-005453-4057qib7 5040 13 acid acid NN cord-005453-4057qib7 5040 14 depletion depletion NN cord-005453-4057qib7 5040 15 reduce reduce VBP cord-005453-4057qib7 5040 16 acute acute JJ cord-005453-4057qib7 5040 17 GVHD GVHD NNP cord-005453-4057qib7 5040 18 incidence incidence NN cord-005453-4057qib7 5040 19 ( ( -LRB- cord-005453-4057qib7 5040 20 BBMT BBMT NNP cord-005453-4057qib7 5040 21 2014 2014 CD cord-005453-4057qib7 5041 1 May;20(5):730 May;20(5):730 NNP cord-005453-4057qib7 5041 2 - - HYPH cord-005453-4057qib7 5041 3 4 4 CD cord-005453-4057qib7 5041 4 ) ) -RRB- cord-005453-4057qib7 5041 5 . . . cord-005453-4057qib7 5042 1 Methods method NNS cord-005453-4057qib7 5042 2 : : : cord-005453-4057qib7 5043 1 This this DT cord-005453-4057qib7 5043 2 international international JJ cord-005453-4057qib7 5043 3 multicentric multicentric NNP cord-005453-4057qib7 5043 4 study study NN cord-005453-4057qib7 5043 5 aimed aim VBN cord-005453-4057qib7 5043 6 to to TO cord-005453-4057qib7 5043 7 study study VB cord-005453-4057qib7 5043 8 the the DT cord-005453-4057qib7 5043 9 association association NN cord-005453-4057qib7 5043 10 of of IN cord-005453-4057qib7 5043 11 uric uric NNP cord-005453-4057qib7 5043 12 acid acid NN cord-005453-4057qib7 5043 13 serum serum NN cord-005453-4057qib7 5043 14 levels level NNS cord-005453-4057qib7 5043 15 before before IN cord-005453-4057qib7 5043 16 start start NN cord-005453-4057qib7 5043 17 of of IN cord-005453-4057qib7 5043 18 conditioning conditioning NN cord-005453-4057qib7 5043 19 with with IN cord-005453-4057qib7 5043 20 alloSCT alloSCT NNP cord-005453-4057qib7 5043 21 outcome outcome NN cord-005453-4057qib7 5043 22 . . . cord-005453-4057qib7 5044 1 Patients patient NNS cord-005453-4057qib7 5044 2 with with IN cord-005453-4057qib7 5044 3 acute acute JJ cord-005453-4057qib7 5044 4 leukemia leukemia NN cord-005453-4057qib7 5044 5 , , , cord-005453-4057qib7 5044 6 lymphoma lymphoma NN cord-005453-4057qib7 5044 7 or or CC cord-005453-4057qib7 5044 8 MDS MDS NNP cord-005453-4057qib7 5044 9 receiving receive VBG cord-005453-4057qib7 5044 10 a a DT cord-005453-4057qib7 5044 11 matched match VBN cord-005453-4057qib7 5044 12 sibling sibling NN cord-005453-4057qib7 5044 13 alloSCT allosct NN cord-005453-4057qib7 5044 14 for for IN cord-005453-4057qib7 5044 15 the the DT cord-005453-4057qib7 5044 16 first first JJ cord-005453-4057qib7 5044 17 time time NN cord-005453-4057qib7 5044 18 were be VBD cord-005453-4057qib7 5044 19 considered consider VBN cord-005453-4057qib7 5044 20 for for IN cord-005453-4057qib7 5044 21 inclusion inclusion NN cord-005453-4057qib7 5044 22 , , , cord-005453-4057qib7 5044 23 regardless regardless RB cord-005453-4057qib7 5044 24 of of IN cord-005453-4057qib7 5044 25 conditionning conditionning NN cord-005453-4057qib7 5044 26 . . . cord-005453-4057qib7 5045 1 Data datum NNS cord-005453-4057qib7 5045 2 were be VBD cord-005453-4057qib7 5045 3 prospectively prospectively RB cord-005453-4057qib7 5045 4 collected collect VBN cord-005453-4057qib7 5045 5 between between IN cord-005453-4057qib7 5045 6 8/2014 8/2014 NNS cord-005453-4057qib7 5045 7 and and CC cord-005453-4057qib7 5045 8 2/2018 2/2018 CD cord-005453-4057qib7 5045 9 . . . cord-005453-4057qib7 5046 1 A a DT cord-005453-4057qib7 5046 2 comparison comparison NN cord-005453-4057qib7 5046 3 of of IN cord-005453-4057qib7 5046 4 outcomes outcome NNS cord-005453-4057qib7 5046 5 between between IN cord-005453-4057qib7 5046 6 patients patient NNS cord-005453-4057qib7 5046 7 with with IN cord-005453-4057qib7 5046 8 high high JJ cord-005453-4057qib7 5046 9 and and CC cord-005453-4057qib7 5046 10 low low JJ cord-005453-4057qib7 5046 11 uric uric NN cord-005453-4057qib7 5046 12 acid acid NN cord-005453-4057qib7 5046 13 level level NN cord-005453-4057qib7 5046 14 was be VBD cord-005453-4057qib7 5046 15 performed perform VBN cord-005453-4057qib7 5046 16 using use VBG cord-005453-4057qib7 5046 17 univariate univariate JJ cord-005453-4057qib7 5046 18 analysis analysis NN cord-005453-4057qib7 5046 19 and and CC cord-005453-4057qib7 5046 20 multivariate multivariate JJ cord-005453-4057qib7 5046 21 analysis analysis NN cord-005453-4057qib7 5046 22 using use VBG cord-005453-4057qib7 5046 23 cause cause NN cord-005453-4057qib7 5046 24 - - HYPH cord-005453-4057qib7 5046 25 specific specific JJ cord-005453-4057qib7 5046 26 Cox Cox NNP cord-005453-4057qib7 5046 27 model model NN cord-005453-4057qib7 5046 28 . . . cord-005453-4057qib7 5047 1 Variables variable NNS cord-005453-4057qib7 5047 2 included include VBN cord-005453-4057qib7 5047 3 in in IN cord-005453-4057qib7 5047 4 the the DT cord-005453-4057qib7 5047 5 multivariate multivariate JJ cord-005453-4057qib7 5047 6 analyses analysis NNS cord-005453-4057qib7 5047 7 were be VBD cord-005453-4057qib7 5047 8 age age NN cord-005453-4057qib7 5047 9 , , , cord-005453-4057qib7 5047 10 sex sex NN cord-005453-4057qib7 5047 11 mismatch mismatch NN cord-005453-4057qib7 5047 12 , , , cord-005453-4057qib7 5047 13 diagnosis diagnosis NN cord-005453-4057qib7 5047 14 , , , cord-005453-4057qib7 5047 15 disease disease NN cord-005453-4057qib7 5047 16 status status NN cord-005453-4057qib7 5047 17 , , , cord-005453-4057qib7 5047 18 Karnofsky Karnofsky NNP cord-005453-4057qib7 5047 19 score score NN cord-005453-4057qib7 5047 20 , , , cord-005453-4057qib7 5047 21 number number NN cord-005453-4057qib7 5047 22 of of IN cord-005453-4057qib7 5047 23 CD34 CD34 NNP cord-005453-4057qib7 5047 24 cells cell NNS cord-005453-4057qib7 5047 25 given give VBN cord-005453-4057qib7 5047 26 , , , cord-005453-4057qib7 5047 27 intensity intensity NN cord-005453-4057qib7 5047 28 of of IN cord-005453-4057qib7 5047 29 conditioning conditioning NN cord-005453-4057qib7 5047 30 , , , cord-005453-4057qib7 5047 31 type type NN cord-005453-4057qib7 5047 32 of of IN cord-005453-4057qib7 5047 33 GVHD GVHD NNP cord-005453-4057qib7 5047 34 prophylaxis prophylaxis NN cord-005453-4057qib7 5047 35 , , , cord-005453-4057qib7 5047 36 ATG ATG NNP cord-005453-4057qib7 5047 37 use use NN cord-005453-4057qib7 5047 38 , , , cord-005453-4057qib7 5047 39 time time NN cord-005453-4057qib7 5047 40 from from IN cord-005453-4057qib7 5047 41 diagnosis diagnosis NN cord-005453-4057qib7 5047 42 to to IN cord-005453-4057qib7 5047 43 transplant transplant NN cord-005453-4057qib7 5047 44 , , , cord-005453-4057qib7 5047 45 year year NN cord-005453-4057qib7 5047 46 of of IN cord-005453-4057qib7 5047 47 transplant transplant NN cord-005453-4057qib7 5047 48 and and CC cord-005453-4057qib7 5047 49 CMV CMV NNP cord-005453-4057qib7 5047 50 status status NN cord-005453-4057qib7 5047 51 . . . cord-005453-4057qib7 5048 1 Results result NNS cord-005453-4057qib7 5048 2 : : : cord-005453-4057qib7 5049 1 Twenty twenty CD cord-005453-4057qib7 5049 2 centers center NNS cord-005453-4057qib7 5049 3 from from IN cord-005453-4057qib7 5049 4 10 10 CD cord-005453-4057qib7 5049 5 European european JJ cord-005453-4057qib7 5049 6 countries country NNS cord-005453-4057qib7 5049 7 reported report VBD cord-005453-4057qib7 5049 8 data datum NNS cord-005453-4057qib7 5049 9 on on IN cord-005453-4057qib7 5049 10 385 385 CD cord-005453-4057qib7 5049 11 alloSCT alloSCT NNP cord-005453-4057qib7 5049 12 recipients recipient NNS cord-005453-4057qib7 5049 13 . . . cord-005453-4057qib7 5050 1 Patient patient JJ cord-005453-4057qib7 5050 2 characteristics characteristic NNS cord-005453-4057qib7 5050 3 are be VBP cord-005453-4057qib7 5050 4 given give VBN cord-005453-4057qib7 5050 5 in in IN cord-005453-4057qib7 5050 6 Table Table NNP cord-005453-4057qib7 5050 7 1 1 CD cord-005453-4057qib7 5050 8 . . . cord-005453-4057qib7 5051 1 The the DT cord-005453-4057qib7 5051 2 uric uric NN cord-005453-4057qib7 5051 3 acid acid NN cord-005453-4057qib7 5051 4 cut cut VBN cord-005453-4057qib7 5051 5 off off RP cord-005453-4057qib7 5051 6 point point NN cord-005453-4057qib7 5051 7 was be VBD cord-005453-4057qib7 5051 8 determined determine VBN cord-005453-4057qib7 5051 9 at at IN cord-005453-4057qib7 5051 10 4.3mg 4.3mg CD cord-005453-4057qib7 5051 11 / / SYM cord-005453-4057qib7 5051 12 dl dl NN cord-005453-4057qib7 5051 13 ( ( -LRB- cord-005453-4057qib7 5051 14 median median NN cord-005453-4057qib7 5051 15 of of IN cord-005453-4057qib7 5051 16 measured measure VBN cord-005453-4057qib7 5051 17 uric uric NN cord-005453-4057qib7 5051 18 acid acid NN cord-005453-4057qib7 5051 19 levels level NNS cord-005453-4057qib7 5051 20 ) ) -RRB- cord-005453-4057qib7 5051 21 . . . cord-005453-4057qib7 5052 1 Overall overall JJ cord-005453-4057qib7 5052 2 survival survival NN cord-005453-4057qib7 5052 3 ( ( -LRB- cord-005453-4057qib7 5052 4 OS OS NNP cord-005453-4057qib7 5052 5 ) ) -RRB- cord-005453-4057qib7 5052 6 and and CC cord-005453-4057qib7 5052 7 progression progression NN cord-005453-4057qib7 5052 8 free free JJ cord-005453-4057qib7 5052 9 survival survival NN cord-005453-4057qib7 5052 10 ( ( -LRB- cord-005453-4057qib7 5052 11 PFS PFS NNP cord-005453-4057qib7 5052 12 ) ) -RRB- cord-005453-4057qib7 5052 13 of of IN cord-005453-4057qib7 5052 14 alloSCT alloSCT NNP cord-005453-4057qib7 5052 15 recipients recipient NNS cord-005453-4057qib7 5052 16 with with IN cord-005453-4057qib7 5052 17 uric uric NN cord-005453-4057qib7 5052 18 acid acid NN cord-005453-4057qib7 5052 19 levels level NNS cord-005453-4057qib7 5052 20 above above IN cord-005453-4057qib7 5052 21 cut cut VBD cord-005453-4057qib7 5052 22 off off RP cord-005453-4057qib7 5052 23 measured measure VBN cord-005453-4057qib7 5052 24 before before IN cord-005453-4057qib7 5052 25 start start NN cord-005453-4057qib7 5052 26 of of IN cord-005453-4057qib7 5052 27 conditioning conditioning NN cord-005453-4057qib7 5052 28 were be VBD cord-005453-4057qib7 5052 29 significantly significantly RB cord-005453-4057qib7 5052 30 shorter short JJR cord-005453-4057qib7 5052 31 ( ( -LRB- cord-005453-4057qib7 5052 32 Figure figure NN cord-005453-4057qib7 5052 33 1A 1a NN cord-005453-4057qib7 5052 34 , , , cord-005453-4057qib7 5052 35 OS OS NNP cord-005453-4057qib7 5052 36 univariate univariate JJ cord-005453-4057qib7 5052 37 HR=2.4 HR=2.4 NNP cord-005453-4057qib7 5052 38 CI=1.6 CI=1.6 NNP cord-005453-4057qib7 5052 39 - - HYPH cord-005453-4057qib7 5052 40 3.7 3.7 CD cord-005453-4057qib7 5052 41 p p NN cord-005453-4057qib7 5052 42 < < XX cord-005453-4057qib7 5052 43 0.001 0.001 XX cord-005453-4057qib7 5052 44 ; ; : cord-005453-4057qib7 5052 45 multivariate multivariate JJ cord-005453-4057qib7 5052 46 HR=2.8 HR=2.8 NNP cord-005453-4057qib7 5052 47 , , , cord-005453-4057qib7 5052 48 CI=1.7 CI=1.7 NNP cord-005453-4057qib7 5052 49 - - HYPH cord-005453-4057qib7 5052 50 4.7 4.7 CD cord-005453-4057qib7 5052 51 , , , cord-005453-4057qib7 5052 52 p p NN cord-005453-4057qib7 5052 53 < < XX cord-005453-4057qib7 5052 54 0.0001 0.0001 CD cord-005453-4057qib7 5052 55 ) ) -RRB- cord-005453-4057qib7 5052 56 ( ( -LRB- cord-005453-4057qib7 5052 57 Figure figure NN cord-005453-4057qib7 5052 58 1B 1b NN cord-005453-4057qib7 5052 59 , , , cord-005453-4057qib7 5052 60 PFS PFS NNP cord-005453-4057qib7 5052 61 univariate univariate JJ cord-005453-4057qib7 5053 1 HR=2 HR=2 NNP cord-005453-4057qib7 5053 2 CI=1.1 CI=1.1 NNP cord-005453-4057qib7 5053 3 - - HYPH cord-005453-4057qib7 5053 4 3.7 3.7 CD cord-005453-4057qib7 5053 5 p=0.02 p=0.02 NN cord-005453-4057qib7 5053 6 ; ; , cord-005453-4057qib7 5053 7 multivariate multivariate JJ cord-005453-4057qib7 5053 8 HR=2.7 HR=2.7 NNP cord-005453-4057qib7 5053 9 , , , cord-005453-4057qib7 5053 10 CI=1.4 CI=1.4 NNP cord-005453-4057qib7 5053 11 - - HYPH cord-005453-4057qib7 5053 12 5 5 CD cord-005453-4057qib7 5053 13 , , , cord-005453-4057qib7 5053 14 p=0.003 p=0.003 NNP cord-005453-4057qib7 5053 15 ) ) -RRB- cord-005453-4057qib7 5053 16 . . . cord-005453-4057qib7 5054 1 Nonrelapse nonrelapse JJ cord-005453-4057qib7 5054 2 mortality mortality NN cord-005453-4057qib7 5054 3 was be VBD cord-005453-4057qib7 5054 4 significantly significantly RB cord-005453-4057qib7 5054 5 increased increase VBN cord-005453-4057qib7 5054 6 in in IN cord-005453-4057qib7 5054 7 alloSCT alloSCT NNP cord-005453-4057qib7 5054 8 recipients recipient NNS cord-005453-4057qib7 5054 9 with with IN cord-005453-4057qib7 5054 10 high high JJ cord-005453-4057qib7 5054 11 uric uric NN cord-005453-4057qib7 5054 12 acid acid NN cord-005453-4057qib7 5054 13 levels level NNS cord-005453-4057qib7 5054 14 prior prior RB cord-005453-4057qib7 5054 15 to to TO cord-005453-4057qib7 5054 16 start start NN cord-005453-4057qib7 5054 17 of of IN cord-005453-4057qib7 5054 18 conditioning conditioning NN cord-005453-4057qib7 5055 1 ( ( -LRB- cord-005453-4057qib7 5055 2 univariate univariate JJ cord-005453-4057qib7 5055 3 HR=2 HR=2 NNP cord-005453-4057qib7 5055 4 CI=1.1 CI=1.1 NNP cord-005453-4057qib7 5055 5 - - HYPH cord-005453-4057qib7 5055 6 3.7 3.7 CD cord-005453-4057qib7 5055 7 p=0.018 p=0.018 NNS cord-005453-4057qib7 5055 8 ; ; , cord-005453-4057qib7 5055 9 multivariate multivariate JJ cord-005453-4057qib7 5055 10 HR=2.65 HR=2.65 NNP cord-005453-4057qib7 5055 11 , , , cord-005453-4057qib7 5055 12 CI=1.41 CI=1.41 NNP cord-005453-4057qib7 5055 13 - - HYPH cord-005453-4057qib7 5055 14 5.01 5.01 CD cord-005453-4057qib7 5055 15 , , , cord-005453-4057qib7 5055 16 p=0.003 p=0.003 NNP cord-005453-4057qib7 5055 17 ) ) -RRB- cord-005453-4057qib7 5055 18 . . . cord-005453-4057qib7 5056 1 In in IN cord-005453-4057qib7 5056 2 addition addition NN cord-005453-4057qib7 5056 3 , , , cord-005453-4057qib7 5056 4 there there EX cord-005453-4057qib7 5056 5 was be VBD cord-005453-4057qib7 5056 6 a a DT cord-005453-4057qib7 5056 7 non non JJ cord-005453-4057qib7 5056 8 - - JJ cord-005453-4057qib7 5056 9 significant significant JJ cord-005453-4057qib7 5056 10 trend trend NN cord-005453-4057qib7 5056 11 towards towards IN cord-005453-4057qib7 5056 12 higher high JJR cord-005453-4057qib7 5056 13 acute acute JJ cord-005453-4057qib7 5056 14 GVHD GVHD NNP cord-005453-4057qib7 5056 15 incidence incidence NN cord-005453-4057qib7 5056 16 ( ( -LRB- cord-005453-4057qib7 5056 17 GVHD GVHD NNP cord-005453-4057qib7 5056 18 Grades Grades NNPS cord-005453-4057qib7 5056 19 II II NNP cord-005453-4057qib7 5056 20 - - HYPH cord-005453-4057qib7 5056 21 IV IV NNP cord-005453-4057qib7 5056 22 univariate univariate JJ cord-005453-4057qib7 5056 23 HR=1.2 hr=1.2 NN cord-005453-4057qib7 5057 1 CI=0.8 ci=0.8 NN cord-005453-4057qib7 5057 2 - - HYPH cord-005453-4057qib7 5057 3 1.9 1.9 CD cord-005453-4057qib7 5057 4 p=0.4 p=0.4 NNPS cord-005453-4057qib7 5058 1 ; ; : cord-005453-4057qib7 5058 2 multivariate multivariate JJ cord-005453-4057qib7 5058 3 HR=1.5 HR=1.5 NNP cord-005453-4057qib7 5058 4 CI=1 CI=1 NNP cord-005453-4057qib7 5058 5 - - HYPH cord-005453-4057qib7 5058 6 2.4 2.4 CD cord-005453-4057qib7 5058 7 , , , cord-005453-4057qib7 5058 8 p=0.08 p=0.08 NNP cord-005453-4057qib7 5058 9 ) ) -RRB- cord-005453-4057qib7 5058 10 in in IN cord-005453-4057qib7 5058 11 alloSCT alloSCT NNP cord-005453-4057qib7 5058 12 recipients recipient NNS cord-005453-4057qib7 5058 13 with with IN cord-005453-4057qib7 5058 14 uric uric NN cord-005453-4057qib7 5058 15 acid acid NN cord-005453-4057qib7 5058 16 levels level NNS cord-005453-4057qib7 5058 17 above above IN cord-005453-4057qib7 5058 18 cut cut VBD cord-005453-4057qib7 5058 19 off off RP cord-005453-4057qib7 5058 20 before before IN cord-005453-4057qib7 5058 21 transplantation transplantation NN cord-005453-4057qib7 5058 22 . . . cord-005453-4057qib7 5059 1 Finally finally RB cord-005453-4057qib7 5059 2 , , , cord-005453-4057qib7 5059 3 the the DT cord-005453-4057qib7 5059 4 incidence incidence NN cord-005453-4057qib7 5059 5 of of IN cord-005453-4057qib7 5059 6 relapse relapse NN cord-005453-4057qib7 5059 7 after after IN cord-005453-4057qib7 5059 8 alloSCT alloSCT NNP cord-005453-4057qib7 5059 9 was be VBD cord-005453-4057qib7 5059 10 moderately moderately RB cord-005453-4057qib7 5059 11 increased increase VBN cord-005453-4057qib7 5059 12 in in IN cord-005453-4057qib7 5059 13 the the DT cord-005453-4057qib7 5059 14 cohort cohort NN cord-005453-4057qib7 5059 15 with with IN cord-005453-4057qib7 5059 16 higher high JJR cord-005453-4057qib7 5059 17 uric uric NN cord-005453-4057qib7 5059 18 acid acid NN cord-005453-4057qib7 5059 19 levels level NNS cord-005453-4057qib7 5059 20 ( ( -LRB- cord-005453-4057qib7 5059 21 univariate univariate JJ cord-005453-4057qib7 5059 22 HR=1.6 HR=1.6 NNP cord-005453-4057qib7 5059 23 CI=1 CI=1 NNP cord-005453-4057qib7 5059 24 - - HYPH cord-005453-4057qib7 5059 25 2.5 2.5 CD cord-005453-4057qib7 5059 26 p=0.09 p=0.09 NN cord-005453-4057qib7 5059 27 ; ; , cord-005453-4057qib7 5059 28 multivariate multivariate JJ cord-005453-4057qib7 5059 29 HR=1.59 hr=1.59 XX cord-005453-4057qib7 5059 30 , , . cord-005453-4057qib7 5060 1 CI=1.02 ci=1.02 LS cord-005453-4057qib7 5060 2 - - HYPH cord-005453-4057qib7 5060 3 2.49 2.49 CD cord-005453-4057qib7 5060 4 , , , cord-005453-4057qib7 5060 5 p=0.04 p=0.04 NNP cord-005453-4057qib7 5060 6 ) ) -RRB- cord-005453-4057qib7 5060 7 . . . cord-005453-4057qib7 5061 1 Conclusions conclusion NNS cord-005453-4057qib7 5061 2 : : : cord-005453-4057qib7 5062 1 High high JJ cord-005453-4057qib7 5062 2 uric uric NN cord-005453-4057qib7 5062 3 acid acid NN cord-005453-4057qib7 5062 4 levels level NNS cord-005453-4057qib7 5062 5 before before IN cord-005453-4057qib7 5062 6 start start NN cord-005453-4057qib7 5062 7 of of IN cord-005453-4057qib7 5062 8 conditioning conditioning NN cord-005453-4057qib7 5062 9 correlate correlate VBP cord-005453-4057qib7 5062 10 with with IN cord-005453-4057qib7 5062 11 high high JJ cord-005453-4057qib7 5062 12 mortality mortality NN cord-005453-4057qib7 5062 13 after after IN cord-005453-4057qib7 5062 14 alloSCT alloSCT NNP cord-005453-4057qib7 5062 15 . . . cord-005453-4057qib7 5063 1 Our -PRON- PRP$ cord-005453-4057qib7 5063 2 results result NNS cord-005453-4057qib7 5063 3 can can MD cord-005453-4057qib7 5063 4 serve serve VB cord-005453-4057qib7 5063 5 as as IN cord-005453-4057qib7 5063 6 rationale rationale NN cord-005453-4057qib7 5063 7 for for IN cord-005453-4057qib7 5063 8 clinical clinical JJ cord-005453-4057qib7 5063 9 trials trial NNS cord-005453-4057qib7 5063 10 on on IN cord-005453-4057qib7 5063 11 depletion depletion NN cord-005453-4057qib7 5063 12 of of IN cord-005453-4057qib7 5063 13 uric uric NN cord-005453-4057qib7 5063 14 acid acid NN cord-005453-4057qib7 5063 15 during during IN cord-005453-4057qib7 5063 16 alloSCT alloSCT NNP cord-005453-4057qib7 5063 17 . . . cord-005453-4057qib7 5064 1 Results result NNS cord-005453-4057qib7 5064 2 : : : cord-005453-4057qib7 5065 1 We -PRON- PRP cord-005453-4057qib7 5065 2 found find VBD cord-005453-4057qib7 5065 3 significant significant JJ cord-005453-4057qib7 5065 4 correlation correlation NN cord-005453-4057qib7 5065 5 between between IN cord-005453-4057qib7 5065 6 donors donor NNS cord-005453-4057qib7 5065 7 ' ' POS cord-005453-4057qib7 5065 8 CTLA-4 CTLA-4 NNS cord-005453-4057qib7 5065 9 +49A +49A NNP cord-005453-4057qib7 5066 1 > > XX cord-005453-4057qib7 5067 1 G g NN cord-005453-4057qib7 5067 2 polymorphism polymorphism NN cord-005453-4057qib7 5067 3 and and CC cord-005453-4057qib7 5067 4 HSCT HSCT NNP cord-005453-4057qib7 5067 5 outcome outcome NN cord-005453-4057qib7 5067 6 . . . cord-005453-4057qib7 5068 1 Genotype Genotype NNP cord-005453-4057qib7 5068 2 AA AA NNP cord-005453-4057qib7 5068 3 was be VBD cord-005453-4057qib7 5068 4 present present JJ cord-005453-4057qib7 5068 5 in in IN cord-005453-4057qib7 5068 6 170 170 CD cord-005453-4057qib7 5068 7 donors donor NNS cord-005453-4057qib7 5068 8 , , , cord-005453-4057qib7 5068 9 AG AG NNP cord-005453-4057qib7 5068 10 in in IN cord-005453-4057qib7 5068 11 183 183 CD cord-005453-4057qib7 5068 12 donors donor NNS cord-005453-4057qib7 5068 13 and and CC cord-005453-4057qib7 5068 14 44 44 CD cord-005453-4057qib7 5068 15 donors donor NNS cord-005453-4057qib7 5068 16 was be VBD cord-005453-4057qib7 5068 17 homozygous homozygous JJ cord-005453-4057qib7 5068 18 for for IN cord-005453-4057qib7 5068 19 G g NN cord-005453-4057qib7 5068 20 allele allele NN cord-005453-4057qib7 5068 21 . . . cord-005453-4057qib7 5069 1 Recipients recipient NNS cord-005453-4057qib7 5069 2 who who WP cord-005453-4057qib7 5069 3 received receive VBD cord-005453-4057qib7 5069 4 graft graft NN cord-005453-4057qib7 5069 5 from from IN cord-005453-4057qib7 5069 6 G g NN cord-005453-4057qib7 5069 7 allele allele NN cord-005453-4057qib7 5069 8 carrier carrier NN cord-005453-4057qib7 5069 9 donors donor NNS cord-005453-4057qib7 5069 10 showed show VBD cord-005453-4057qib7 5069 11 significantly significantly RB cord-005453-4057qib7 5069 12 increased increase VBN cord-005453-4057qib7 5069 13 cumulative cumulative JJ cord-005453-4057qib7 5069 14 incidence incidence NN cord-005453-4057qib7 5069 15 of of IN cord-005453-4057qib7 5069 16 relapse relapse NN cord-005453-4057qib7 5069 17 ( ( -LRB- cord-005453-4057qib7 5069 18 at at IN cord-005453-4057qib7 5069 19 24 24 CD cord-005453-4057qib7 5069 20 months month NNS cord-005453-4057qib7 5069 21 AA AA NNP cord-005453-4057qib7 5069 22 : : : cord-005453-4057qib7 5069 23 20.7 20.7 CD cord-005453-4057qib7 5069 24 % % NN cord-005453-4057qib7 5069 25 , , , cord-005453-4057qib7 5069 26 AG AG NNP cord-005453-4057qib7 5069 27 : : : cord-005453-4057qib7 5069 28 23.6 23.6 CD cord-005453-4057qib7 5069 29 % % NN cord-005453-4057qib7 5069 30 and and CC cord-005453-4057qib7 5069 31 GG GG NNP cord-005453-4057qib7 5069 32 : : : cord-005453-4057qib7 5069 33 34.3 34.3 CD cord-005453-4057qib7 5069 34 % % NN cord-005453-4057qib7 5069 35 ; ; : cord-005453-4057qib7 5069 36 p=0.04 p=0.04 NNP cord-005453-4057qib7 5069 37 ) ) -RRB- cord-005453-4057qib7 5069 38 . . . cord-005453-4057qib7 5070 1 On on IN cord-005453-4057qib7 5070 2 contrary contrary JJ cord-005453-4057qib7 5070 3 , , , cord-005453-4057qib7 5070 4 the the DT cord-005453-4057qib7 5070 5 frequency frequency NN cord-005453-4057qib7 5070 6 of of IN cord-005453-4057qib7 5070 7 the the DT cord-005453-4057qib7 5070 8 acute acute JJ cord-005453-4057qib7 5070 9 GvHD GvHD NNP cord-005453-4057qib7 5070 10 grades grade NNS cord-005453-4057qib7 5070 11 III III NNP cord-005453-4057qib7 5070 12 - - HYPH cord-005453-4057qib7 5070 13 IV IV NNP cord-005453-4057qib7 5070 14 and and CC cord-005453-4057qib7 5070 15 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 5070 16 ( ( -LRB- cord-005453-4057qib7 5070 17 CMV CMV NNP cord-005453-4057qib7 5070 18 ) ) -RRB- cord-005453-4057qib7 5070 19 reactivation reactivation NN cord-005453-4057qib7 5070 20 / / SYM cord-005453-4057qib7 5070 21 disease disease NN cord-005453-4057qib7 5070 22 decreased decrease VBD cord-005453-4057qib7 5070 23 according accord VBG cord-005453-4057qib7 5070 24 to to IN cord-005453-4057qib7 5070 25 the the DT cord-005453-4057qib7 5070 26 presence presence NN cord-005453-4057qib7 5070 27 of of IN cord-005453-4057qib7 5070 28 the the DT cord-005453-4057qib7 5070 29 G g NN cord-005453-4057qib7 5070 30 allele allele NN cord-005453-4057qib7 5070 31 in in IN cord-005453-4057qib7 5070 32 the the DT cord-005453-4057qib7 5070 33 donor donor NN cord-005453-4057qib7 5070 34 CTLA-4 CTLA-4 NNS cord-005453-4057qib7 5070 35 genotype genotype NN cord-005453-4057qib7 5070 36 [ [ -LRB- cord-005453-4057qib7 5070 37 aGvHD agvhd NN cord-005453-4057qib7 5070 38 : : : cord-005453-4057qib7 5070 39 AA aa NN cord-005453-4057qib7 5070 40 : : : cord-005453-4057qib7 5070 41 20 20 CD cord-005453-4057qib7 5070 42 % % NN cord-005453-4057qib7 5070 43 , , , cord-005453-4057qib7 5070 44 AG AG NNP cord-005453-4057qib7 5070 45 : : : cord-005453-4057qib7 5070 46 12 12 CD cord-005453-4057qib7 5070 47 % % NN cord-005453-4057qib7 5070 48 , , , cord-005453-4057qib7 5070 49 GG GG NNP cord-005453-4057qib7 5070 50 : : : cord-005453-4057qib7 5070 51 5 5 CD cord-005453-4057qib7 5070 52 % % NN cord-005453-4057qib7 5070 53 ; ; : cord-005453-4057qib7 5070 54 p= p= JJ cord-005453-4057qib7 5070 55 0.014 0.014 CD cord-005453-4057qib7 5070 56 ; ; : cord-005453-4057qib7 5070 57 CMV CMV NNP cord-005453-4057qib7 5070 58 : : : cord-005453-4057qib7 5070 59 AA AA NNP cord-005453-4057qib7 5070 60 : : : cord-005453-4057qib7 5070 61 24 24 CD cord-005453-4057qib7 5070 62 % % NN cord-005453-4057qib7 5070 63 , , , cord-005453-4057qib7 5070 64 AG AG NNP cord-005453-4057qib7 5070 65 : : : cord-005453-4057qib7 5070 66 16 16 CD cord-005453-4057qib7 5070 67 % % NN cord-005453-4057qib7 5070 68 , , , cord-005453-4057qib7 5070 69 GG GG NNP cord-005453-4057qib7 5070 70 : : : cord-005453-4057qib7 5070 71 9 9 CD cord-005453-4057qib7 5070 72 % % NN cord-005453-4057qib7 5070 73 ; ; : cord-005453-4057qib7 5070 74 p= p= JJ cord-005453-4057qib7 5070 75 0.039 0.039 CD cord-005453-4057qib7 5070 76 ] ] -RRB- cord-005453-4057qib7 5070 77 . . . cord-005453-4057qib7 5071 1 Cumulative cumulative JJ cord-005453-4057qib7 5071 2 incidence incidence NN cord-005453-4057qib7 5071 3 of of IN cord-005453-4057qib7 5071 4 aGvHD agvhd NN cord-005453-4057qib7 5071 5 was be VBD cord-005453-4057qib7 5071 6 also also RB cord-005453-4057qib7 5071 7 markedly markedly RB cord-005453-4057qib7 5071 8 decreased decrease VBN cord-005453-4057qib7 5071 9 among among IN cord-005453-4057qib7 5071 10 patients patient NNS cord-005453-4057qib7 5071 11 with with IN cord-005453-4057qib7 5071 12 G g NN cord-005453-4057qib7 5071 13 allele allele NN cord-005453-4057qib7 5071 14 carrier carrier NN cord-005453-4057qib7 5071 15 donors donor NNS cord-005453-4057qib7 5071 16 ( ( -LRB- cord-005453-4057qib7 5071 17 at at IN cord-005453-4057qib7 5071 18 100 100 CD cord-005453-4057qib7 5071 19 days day NNS cord-005453-4057qib7 5071 20 AA AA NNP cord-005453-4057qib7 5071 21 : : : cord-005453-4057qib7 5071 22 19.9 19.9 CD cord-005453-4057qib7 5071 23 % % NN cord-005453-4057qib7 5071 24 , , , cord-005453-4057qib7 5071 25 AG AG NNP cord-005453-4057qib7 5071 26 : : : cord-005453-4057qib7 5071 27 10.4 10.4 CD cord-005453-4057qib7 5071 28 % % NN cord-005453-4057qib7 5071 29 , , , cord-005453-4057qib7 5071 30 GG GG NNP cord-005453-4057qib7 5071 31 : : : cord-005453-4057qib7 5071 32 6.4 6.4 CD cord-005453-4057qib7 5071 33 % % NN cord-005453-4057qib7 5071 34 ; ; , cord-005453-4057qib7 5071 35 p=0.01 p=0.01 NNP cord-005453-4057qib7 5071 36 ) ) -RRB- cord-005453-4057qib7 5071 37 . . . cord-005453-4057qib7 5072 1 Donor donor NN cord-005453-4057qib7 5072 2 genotype genotype NN cord-005453-4057qib7 5072 3 similarly similarly RB cord-005453-4057qib7 5072 4 influenced influence VBD cord-005453-4057qib7 5072 5 HSCT HSCT NNP cord-005453-4057qib7 5072 6 outcome outcome NN cord-005453-4057qib7 5072 7 in in IN cord-005453-4057qib7 5072 8 MUD MUD NNP cord-005453-4057qib7 5072 9 donor donor NN cord-005453-4057qib7 5072 10 and and CC cord-005453-4057qib7 5072 11 MAC MAC NNP cord-005453-4057qib7 5072 12 conditioning conditioning NN cord-005453-4057qib7 5072 13 subgroups subgroup NNS cord-005453-4057qib7 5072 14 . . . cord-005453-4057qib7 5073 1 Overall overall JJ cord-005453-4057qib7 5073 2 survival survival NN cord-005453-4057qib7 5073 3 ( ( -LRB- cord-005453-4057qib7 5073 4 OS OS NNP cord-005453-4057qib7 5073 5 ) ) -RRB- cord-005453-4057qib7 5073 6 was be VBD cord-005453-4057qib7 5073 7 not not RB cord-005453-4057qib7 5073 8 different different JJ cord-005453-4057qib7 5073 9 in in IN cord-005453-4057qib7 5073 10 patient patient JJ cord-005453-4057qib7 5073 11 subgroups subgroup NNS cord-005453-4057qib7 5073 12 according accord VBG cord-005453-4057qib7 5073 13 to to IN cord-005453-4057qib7 5073 14 donor donor NN cord-005453-4057qib7 5073 15 genotypes genotype NNS cord-005453-4057qib7 5073 16 [ [ -LRB- cord-005453-4057qib7 5073 17 OS os NN cord-005453-4057qib7 5073 18 at at IN cord-005453-4057qib7 5073 19 24 24 CD cord-005453-4057qib7 5073 20 months month NNS cord-005453-4057qib7 5073 21 : : : cord-005453-4057qib7 5073 22 AA aa NN cord-005453-4057qib7 5073 23 : : : cord-005453-4057qib7 5073 24 55.5 55.5 CD cord-005453-4057qib7 5073 25 ±3.8 ±3.8 NNP cord-005453-4057qib7 5073 26 % % NN cord-005453-4057qib7 5073 27 , , , cord-005453-4057qib7 5073 28 AG AG NNP cord-005453-4057qib7 5073 29 : : : cord-005453-4057qib7 5073 30 54.4±3.7 54.4±3.7 CD cord-005453-4057qib7 5073 31 % % NN cord-005453-4057qib7 5073 32 , , , cord-005453-4057qib7 5073 33 GG GG NNP cord-005453-4057qib7 5073 34 : : : cord-005453-4057qib7 5073 35 49.4±7.6 49.4±7.6 CD cord-005453-4057qib7 5073 36 % % NN cord-005453-4057qib7 5073 37 ; ; : cord-005453-4057qib7 5073 38 p= p= NN cord-005453-4057qib7 5073 39 0.68 0.68 CD cord-005453-4057qib7 5073 40 ] ] -RRB- cord-005453-4057qib7 5073 41 . . . cord-005453-4057qib7 5074 1 We -PRON- PRP cord-005453-4057qib7 5074 2 did do VBD cord-005453-4057qib7 5074 3 not not RB cord-005453-4057qib7 5074 4 find find VB cord-005453-4057qib7 5074 5 any any DT cord-005453-4057qib7 5074 6 correlation correlation NN cord-005453-4057qib7 5074 7 between between IN cord-005453-4057qib7 5074 8 recipients recipient NNS cord-005453-4057qib7 5074 9 ' ' POS cord-005453-4057qib7 5074 10 CTLA-4 CTLA-4 NNS cord-005453-4057qib7 5074 11 +49A +49A NNP cord-005453-4057qib7 5075 1 > > XX cord-005453-4057qib7 5076 1 G g NN cord-005453-4057qib7 5076 2 polymorphism polymorphism NN cord-005453-4057qib7 5076 3 and and CC cord-005453-4057qib7 5076 4 HSCT HSCT NNP cord-005453-4057qib7 5076 5 outcome outcome NN cord-005453-4057qib7 5076 6 . . . cord-005453-4057qib7 5077 1 Conclusions conclusion NNS cord-005453-4057qib7 5077 2 : : : cord-005453-4057qib7 5078 1 Several several JJ cord-005453-4057qib7 5078 2 CTLA-4 CTLA-4 NNS cord-005453-4057qib7 5078 3 SNPs snp NNS cord-005453-4057qib7 5078 4 have have VBP cord-005453-4057qib7 5078 5 previously previously RB cord-005453-4057qib7 5078 6 been be VBN cord-005453-4057qib7 5078 7 described describe VBN cord-005453-4057qib7 5078 8 to to TO cord-005453-4057qib7 5078 9 be be VB cord-005453-4057qib7 5078 10 associated associate VBN cord-005453-4057qib7 5078 11 with with IN cord-005453-4057qib7 5078 12 relapse relapse NN cord-005453-4057qib7 5078 13 rate rate NN cord-005453-4057qib7 5078 14 , , , cord-005453-4057qib7 5078 15 incidence incidence NN cord-005453-4057qib7 5078 16 of of IN cord-005453-4057qib7 5078 17 aGvHD agvhd NN cord-005453-4057qib7 5078 18 and and CC cord-005453-4057qib7 5078 19 OS OS NNP cord-005453-4057qib7 5078 20 , , , cord-005453-4057qib7 5078 21 but but CC cord-005453-4057qib7 5078 22 results result NNS cord-005453-4057qib7 5078 23 are be VBP cord-005453-4057qib7 5078 24 often often RB cord-005453-4057qib7 5078 25 contradictory contradictory JJ cord-005453-4057qib7 5078 26 in in IN cord-005453-4057qib7 5078 27 the the DT cord-005453-4057qib7 5078 28 publications publication NNS cord-005453-4057qib7 5078 29 . . . cord-005453-4057qib7 5079 1 In in IN cord-005453-4057qib7 5079 2 our -PRON- PRP$ cord-005453-4057qib7 5079 3 study study NN cord-005453-4057qib7 5079 4 , , , cord-005453-4057qib7 5079 5 CTLA-4 CTLA-4 NNP cord-005453-4057qib7 5079 6 +49A +49A NNP cord-005453-4057qib7 5080 1 > > XX cord-005453-4057qib7 5081 1 G g NN cord-005453-4057qib7 5081 2 polymorphism polymorphism NN cord-005453-4057qib7 5081 3 of of IN cord-005453-4057qib7 5081 4 HSCT HSCT NNP cord-005453-4057qib7 5081 5 donors donor NNS cord-005453-4057qib7 5081 6 influenced influence VBD cord-005453-4057qib7 5081 7 risk risk NN cord-005453-4057qib7 5081 8 of of IN cord-005453-4057qib7 5081 9 relapse relapse NN cord-005453-4057qib7 5081 10 , , , cord-005453-4057qib7 5081 11 aGvHD agvhd NN cord-005453-4057qib7 5081 12 , , , cord-005453-4057qib7 5081 13 CMV CMV NNP cord-005453-4057qib7 5081 14 and and CC cord-005453-4057qib7 5081 15 cause cause NN cord-005453-4057qib7 5081 16 of of IN cord-005453-4057qib7 5081 17 death death NN cord-005453-4057qib7 5081 18 , , , cord-005453-4057qib7 5081 19 but but CC cord-005453-4057qib7 5081 20 not not RB cord-005453-4057qib7 5081 21 overall overall JJ cord-005453-4057qib7 5081 22 survival survival NN cord-005453-4057qib7 5081 23 . . . cord-005453-4057qib7 5082 1 The the DT cord-005453-4057qib7 5082 2 genotyping genotyping NN cord-005453-4057qib7 5082 3 of of IN cord-005453-4057qib7 5082 4 CTLA-4 CTLA-4 NNS cord-005453-4057qib7 5082 5 +49A +49A NNP cord-005453-4057qib7 5083 1 > > XX cord-005453-4057qib7 5084 1 G g NN cord-005453-4057qib7 5084 2 polymorphism polymorphism NN cord-005453-4057qib7 5084 3 in in IN cord-005453-4057qib7 5084 4 donors donor NNS cord-005453-4057qib7 5084 5 may may MD cord-005453-4057qib7 5084 6 help help VB cord-005453-4057qib7 5084 7 in in IN cord-005453-4057qib7 5084 8 the the DT cord-005453-4057qib7 5084 9 risk risk NN cord-005453-4057qib7 5084 10 assessment assessment NN cord-005453-4057qib7 5084 11 process process NN cord-005453-4057qib7 5084 12 and and CC cord-005453-4057qib7 5084 13 the the DT cord-005453-4057qib7 5084 14 choice choice NN cord-005453-4057qib7 5084 15 of of IN cord-005453-4057qib7 5084 16 personalised personalised JJ cord-005453-4057qib7 5084 17 therapy therapy NN cord-005453-4057qib7 5084 18 . . . cord-005453-4057qib7 5085 1 Disclosure disclosure NN cord-005453-4057qib7 5085 2 : : : cord-005453-4057qib7 5085 3 Nothing nothing NN cord-005453-4057qib7 5085 4 to to TO cord-005453-4057qib7 5085 5 declare declare VB cord-005453-4057qib7 5085 6 . . . cord-005453-4057qib7 5086 1 Background background NN cord-005453-4057qib7 5086 2 : : : cord-005453-4057qib7 5087 1 Although although IN cord-005453-4057qib7 5087 2 steroids steroid NNS cord-005453-4057qib7 5087 3 remain remain VBP cord-005453-4057qib7 5087 4 first first JJ cord-005453-4057qib7 5087 5 - - HYPH cord-005453-4057qib7 5087 6 line line NN cord-005453-4057qib7 5087 7 therapy therapy NN cord-005453-4057qib7 5087 8 for for IN cord-005453-4057qib7 5087 9 the the DT cord-005453-4057qib7 5087 10 treatment treatment NN cord-005453-4057qib7 5087 11 of of IN cord-005453-4057qib7 5087 12 acute acute JJ cord-005453-4057qib7 5087 13 graft graft NN cord-005453-4057qib7 5087 14 versus versus IN cord-005453-4057qib7 5087 15 host host NN cord-005453-4057qib7 5087 16 disease disease NN cord-005453-4057qib7 5087 17 ( ( -LRB- cord-005453-4057qib7 5087 18 aGVHD aGVHD NNP cord-005453-4057qib7 5087 19 ) ) -RRB- cord-005453-4057qib7 5087 20 , , , cord-005453-4057qib7 5087 21 response response NN cord-005453-4057qib7 5087 22 rates rate NNS cord-005453-4057qib7 5087 23 in in IN cord-005453-4057qib7 5087 24 patients patient NNS cord-005453-4057qib7 5087 25 with with IN cord-005453-4057qib7 5087 26 grade grade NN cord-005453-4057qib7 5087 27 III III NNP cord-005453-4057qib7 5087 28 - - HYPH cord-005453-4057qib7 5087 29 IV IV NNP cord-005453-4057qib7 5087 30 disease disease NN cord-005453-4057qib7 5087 31 are be VBP cord-005453-4057qib7 5087 32 poor poor JJ cord-005453-4057qib7 5087 33 , , , cord-005453-4057qib7 5087 34 with with IN cord-005453-4057qib7 5087 35 no no DT cord-005453-4057qib7 5087 36 apparent apparent JJ cord-005453-4057qib7 5087 37 improvement improvement NN cord-005453-4057qib7 5087 38 in in IN cord-005453-4057qib7 5087 39 survival survival NN cord-005453-4057qib7 5087 40 over over IN cord-005453-4057qib7 5087 41 the the DT cord-005453-4057qib7 5087 42 past past JJ cord-005453-4057qib7 5087 43 15 15 CD cord-005453-4057qib7 5087 44 years year NNS cord-005453-4057qib7 5087 45 . . . cord-005453-4057qib7 5088 1 We -PRON- PRP cord-005453-4057qib7 5088 2 performed perform VBD cord-005453-4057qib7 5088 3 a a DT cord-005453-4057qib7 5088 4 prospective prospective JJ cord-005453-4057qib7 5088 5 , , , cord-005453-4057qib7 5088 6 multicenter multicenter JJ cord-005453-4057qib7 5088 7 trial trial NN cord-005453-4057qib7 5088 8 to to TO cord-005453-4057qib7 5088 9 assess assess VB cord-005453-4057qib7 5088 10 the the DT cord-005453-4057qib7 5088 11 efficacy efficacy NN cord-005453-4057qib7 5088 12 and and CC cord-005453-4057qib7 5088 13 safety safety NN cord-005453-4057qib7 5088 14 of of IN cord-005453-4057qib7 5088 15 the the DT cord-005453-4057qib7 5088 16 combination combination NN cord-005453-4057qib7 5088 17 of of IN cord-005453-4057qib7 5088 18 ruxolitinib ruxolitinib NN cord-005453-4057qib7 5088 19 and and CC cord-005453-4057qib7 5088 20 etanercept etanercept NNP cord-005453-4057qib7 5088 21 as as IN cord-005453-4057qib7 5088 22 a a DT cord-005453-4057qib7 5088 23 novel novel JJ cord-005453-4057qib7 5088 24 approach approach NN cord-005453-4057qib7 5088 25 to to TO cord-005453-4057qib7 5088 26 treat treat VB cord-005453-4057qib7 5088 27 grades grade NNS cord-005453-4057qib7 5088 28 III III NNP cord-005453-4057qib7 5088 29 - - HYPH cord-005453-4057qib7 5088 30 IV IV NNP cord-005453-4057qib7 5088 31 SR SR NNP cord-005453-4057qib7 5088 32 - - HYPH cord-005453-4057qib7 5088 33 aGVHD aGVHD NNP cord-005453-4057qib7 5088 34 . . . cord-005453-4057qib7 5089 1 Methods method NNS cord-005453-4057qib7 5089 2 : : : cord-005453-4057qib7 5090 1 Forty forty CD cord-005453-4057qib7 5090 2 malignant malignant JJ cord-005453-4057qib7 5090 3 hematologic hematologic JJ cord-005453-4057qib7 5090 4 disease disease NN cord-005453-4057qib7 5090 5 patients patient NNS cord-005453-4057qib7 5090 6 with with IN cord-005453-4057qib7 5090 7 grades grade NNS cord-005453-4057qib7 5090 8 III III NNP cord-005453-4057qib7 5090 9 - - HYPH cord-005453-4057qib7 5090 10 IV IV NNP cord-005453-4057qib7 5090 11 SR SR NNP cord-005453-4057qib7 5090 12 - - HYPH cord-005453-4057qib7 5090 13 aGVHD aGVHD NNP cord-005453-4057qib7 5091 1 after after IN cord-005453-4057qib7 5091 2 allo allo NNP cord-005453-4057qib7 5091 3 - - HYPH cord-005453-4057qib7 5091 4 SCT SCT NNP cord-005453-4057qib7 5091 5 from from IN cord-005453-4057qib7 5091 6 three three CD cord-005453-4057qib7 5091 7 centers center NNS cord-005453-4057qib7 5091 8 in in IN cord-005453-4057qib7 5091 9 East East NNP cord-005453-4057qib7 5091 10 China China NNP cord-005453-4057qib7 5091 11 were be VBD cord-005453-4057qib7 5091 12 enrolled enrol VBN cord-005453-4057qib7 5091 13 from from IN cord-005453-4057qib7 5091 14 January January NNP cord-005453-4057qib7 5091 15 2017 2017 CD cord-005453-4057qib7 5091 16 to to IN cord-005453-4057qib7 5091 17 June June NNP cord-005453-4057qib7 5091 18 2018 2018 CD cord-005453-4057qib7 5091 19 . . . cord-005453-4057qib7 5092 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5092 2 was be VBD cord-005453-4057qib7 5092 3 initiated initiate VBN cord-005453-4057qib7 5092 4 at at IN cord-005453-4057qib7 5092 5 a a DT cord-005453-4057qib7 5092 6 dose dose NN cord-005453-4057qib7 5092 7 of of IN cord-005453-4057qib7 5092 8 5 5 CD cord-005453-4057qib7 5092 9 - - SYM cord-005453-4057qib7 5092 10 10 10 CD cord-005453-4057qib7 5092 11 mg mg NNP cord-005453-4057qib7 5092 12 BID BID NNP cord-005453-4057qib7 5092 13 for for IN cord-005453-4057qib7 5092 14 2 2 CD cord-005453-4057qib7 5092 15 months month NNS cord-005453-4057qib7 5092 16 , , , cord-005453-4057qib7 5092 17 and and CC cord-005453-4057qib7 5092 18 then then RB cord-005453-4057qib7 5092 19 tapered tapered JJ cord-005453-4057qib7 5092 20 gradually gradually RB cord-005453-4057qib7 5092 21 for for IN cord-005453-4057qib7 5092 22 another another DT cord-005453-4057qib7 5092 23 one one CD cord-005453-4057qib7 5092 24 month month NN cord-005453-4057qib7 5092 25 . . . cord-005453-4057qib7 5093 1 Etanercept Etanercept NNP cord-005453-4057qib7 5093 2 was be VBD cord-005453-4057qib7 5093 3 administrated administrate VBN cord-005453-4057qib7 5093 4 at at IN cord-005453-4057qib7 5093 5 25 25 CD cord-005453-4057qib7 5093 6 mg mg NNP cord-005453-4057qib7 5093 7 BIW BIW NNP cord-005453-4057qib7 5093 8 for for IN cord-005453-4057qib7 5093 9 2 2 CD cord-005453-4057qib7 5093 10 - - SYM cord-005453-4057qib7 5093 11 8 8 CD cord-005453-4057qib7 5093 12 weeks week NNS cord-005453-4057qib7 5093 13 . . . cord-005453-4057qib7 5094 1 Results result NNS cord-005453-4057qib7 5094 2 : : : cord-005453-4057qib7 5095 1 The the DT cord-005453-4057qib7 5095 2 median median JJ cord-005453-4057qib7 5095 3 age age NN cord-005453-4057qib7 5095 4 of of IN cord-005453-4057qib7 5095 5 patients patient NNS cord-005453-4057qib7 5095 6 was be VBD cord-005453-4057qib7 5095 7 25 25 CD cord-005453-4057qib7 5096 1 ( ( -LRB- cord-005453-4057qib7 5096 2 range range NNP cord-005453-4057qib7 5096 3 15 15 CD cord-005453-4057qib7 5096 4 - - SYM cord-005453-4057qib7 5096 5 59 59 CD cord-005453-4057qib7 5096 6 ) ) -RRB- cord-005453-4057qib7 5096 7 years year NNS cord-005453-4057qib7 5096 8 . . . cord-005453-4057qib7 5097 1 At at IN cord-005453-4057qib7 5097 2 day day NN cord-005453-4057qib7 5097 3 30 30 CD cord-005453-4057qib7 5097 4 after after IN cord-005453-4057qib7 5097 5 the the DT cord-005453-4057qib7 5097 6 combination combination NN cord-005453-4057qib7 5097 7 treatment treatment NN cord-005453-4057qib7 5097 8 , , , cord-005453-4057qib7 5097 9 the the DT cord-005453-4057qib7 5097 10 overall overall JJ cord-005453-4057qib7 5097 11 response response NN cord-005453-4057qib7 5097 12 rate rate NN cord-005453-4057qib7 5097 13 ( ( -LRB- cord-005453-4057qib7 5097 14 ORR ORR NNP cord-005453-4057qib7 5097 15 ) ) -RRB- cord-005453-4057qib7 5097 16 was be VBD cord-005453-4057qib7 5097 17 90 90 CD cord-005453-4057qib7 5097 18 % % NN cord-005453-4057qib7 5097 19 including include VBG cord-005453-4057qib7 5097 20 30 30 CD cord-005453-4057qib7 5097 21 CRs cr NNS cord-005453-4057qib7 5097 22 ( ( -LRB- cord-005453-4057qib7 5097 23 75 75 CD cord-005453-4057qib7 5097 24 % % NN cord-005453-4057qib7 5097 25 ) ) -RRB- cord-005453-4057qib7 5097 26 and and CC cord-005453-4057qib7 5097 27 6 6 CD cord-005453-4057qib7 5097 28 PRs pr NNS cord-005453-4057qib7 5097 29 ( ( -LRB- cord-005453-4057qib7 5097 30 15 15 CD cord-005453-4057qib7 5097 31 % % NN cord-005453-4057qib7 5097 32 ) ) -RRB- cord-005453-4057qib7 5097 33 . . . cord-005453-4057qib7 5098 1 The the DT cord-005453-4057qib7 5098 2 median median JJ cord-005453-4057qib7 5098 3 time time NN cord-005453-4057qib7 5098 4 to to IN cord-005453-4057qib7 5098 5 the the DT cord-005453-4057qib7 5098 6 optimal optimal JJ cord-005453-4057qib7 5098 7 response response NN cord-005453-4057qib7 5098 8 was be VBD cord-005453-4057qib7 5098 9 13 13 CD cord-005453-4057qib7 5099 1 ( ( -LRB- cord-005453-4057qib7 5099 2 range range NNP cord-005453-4057qib7 5099 3 3 3 CD cord-005453-4057qib7 5099 4 - - SYM cord-005453-4057qib7 5099 5 34 34 CD cord-005453-4057qib7 5099 6 ) ) -RRB- cord-005453-4057qib7 5099 7 days day NNS cord-005453-4057qib7 5099 8 . . . cord-005453-4057qib7 5100 1 The the DT cord-005453-4057qib7 5100 2 incidences incidence NNS cord-005453-4057qib7 5100 3 of of IN cord-005453-4057qib7 5100 4 CR cr NN cord-005453-4057qib7 5100 5 per per IN cord-005453-4057qib7 5100 6 organ organ NN cord-005453-4057qib7 5100 7 were be VBD cord-005453-4057qib7 5100 8 95.7 95.7 CD cord-005453-4057qib7 5100 9 % % NN cord-005453-4057qib7 5100 10 , , , cord-005453-4057qib7 5100 11 80.8 80.8 CD cord-005453-4057qib7 5100 12 % % NN cord-005453-4057qib7 5100 13 , , , cord-005453-4057qib7 5100 14 and and CC cord-005453-4057qib7 5100 15 80 80 CD cord-005453-4057qib7 5100 16 % % NN cord-005453-4057qib7 5100 17 for for IN cord-005453-4057qib7 5100 18 skin skin NN cord-005453-4057qib7 5100 19 , , , cord-005453-4057qib7 5100 20 liver liver NN cord-005453-4057qib7 5100 21 , , , cord-005453-4057qib7 5100 22 and and CC cord-005453-4057qib7 5100 23 gut gut NN cord-005453-4057qib7 5100 24 , , , cord-005453-4057qib7 5100 25 respectively respectively RB cord-005453-4057qib7 5100 26 . . . cord-005453-4057qib7 5101 1 The the DT cord-005453-4057qib7 5101 2 aGVHD aGVHD NNP cord-005453-4057qib7 5101 3 relapse relapse NN cord-005453-4057qib7 5101 4 rate rate NN cord-005453-4057qib7 5101 5 was be VBD cord-005453-4057qib7 5101 6 analyzed analyze VBN cord-005453-4057qib7 5101 7 for for IN cord-005453-4057qib7 5101 8 the the DT cord-005453-4057qib7 5101 9 patients patient NNS cord-005453-4057qib7 5101 10 who who WP cord-005453-4057qib7 5101 11 had have VBD cord-005453-4057qib7 5101 12 achieved achieve VBN cord-005453-4057qib7 5101 13 CR CR NNP cord-005453-4057qib7 5101 14 or or CC cord-005453-4057qib7 5101 15 PR PR NNP cord-005453-4057qib7 5101 16 and and CC cord-005453-4057qib7 5101 17 survived survive VBD cord-005453-4057qib7 5101 18 beyond beyond IN cord-005453-4057qib7 5101 19 60 60 CD cord-005453-4057qib7 5101 20 days day NNS cord-005453-4057qib7 5101 21 . . . cord-005453-4057qib7 5102 1 Relapses relapse NNS cord-005453-4057qib7 5102 2 in in IN cord-005453-4057qib7 5102 3 aGVHD aGVHD NNP cord-005453-4057qib7 5102 4 occurred occur VBD cord-005453-4057qib7 5102 5 in in IN cord-005453-4057qib7 5102 6 9.38 9.38 CD cord-005453-4057qib7 5102 7 % % NN cord-005453-4057qib7 5102 8 ( ( -LRB- cord-005453-4057qib7 5102 9 3/ 3/ CD cord-005453-4057qib7 5102 10 32 32 CD cord-005453-4057qib7 5102 11 ) ) -RRB- cord-005453-4057qib7 5102 12 of of IN cord-005453-4057qib7 5102 13 responsive responsive JJ cord-005453-4057qib7 5102 14 patients patient NNS cord-005453-4057qib7 5102 15 . . . cord-005453-4057qib7 5103 1 The the DT cord-005453-4057qib7 5103 2 patients patient NNS cord-005453-4057qib7 5103 3 who who WP cord-005453-4057qib7 5103 4 received receive VBD cord-005453-4057qib7 5103 5 ruxolitinib ruxolitinib NN cord-005453-4057qib7 5103 6 within within IN cord-005453-4057qib7 5103 7 14 14 CD cord-005453-4057qib7 5103 8 days day NNS cord-005453-4057qib7 5103 9 after after IN cord-005453-4057qib7 5103 10 aGVHD aGVHD NNP cord-005453-4057qib7 5103 11 onset onset NN cord-005453-4057qib7 5103 12 have have VBP cord-005453-4057qib7 5103 13 a a DT cord-005453-4057qib7 5103 14 significant significant JJ cord-005453-4057qib7 5103 15 higher high JJR cord-005453-4057qib7 5103 16 CR cr NN cord-005453-4057qib7 5103 17 rate rate NN cord-005453-4057qib7 5103 18 that that IN cord-005453-4057qib7 5103 19 those those DT cord-005453-4057qib7 5103 20 with with IN cord-005453-4057qib7 5103 21 delayed delay VBN cord-005453-4057qib7 5103 22 ruxolitinib ruxolitinib JJ cord-005453-4057qib7 5103 23 therapy therapy NN cord-005453-4057qib7 5103 24 ( ( -LRB- cord-005453-4057qib7 5103 25 96.2 96.2 CD cord-005453-4057qib7 5103 26 % % NN cord-005453-4057qib7 5103 27 vs. vs. IN cord-005453-4057qib7 5103 28 42.9 42.9 CD cord-005453-4057qib7 5103 29 % % NN cord-005453-4057qib7 5103 30 , , , cord-005453-4057qib7 5103 31 p=0.001 p=0.001 NNP cord-005453-4057qib7 5103 32 ) ) -RRB- cord-005453-4057qib7 5103 33 . . . cord-005453-4057qib7 5104 1 And and CC cord-005453-4057qib7 5104 2 the the DT cord-005453-4057qib7 5104 3 patients patient NNS cord-005453-4057qib7 5104 4 without without IN cord-005453-4057qib7 5104 5 gut gut NN cord-005453-4057qib7 5104 6 infections infection NNS cord-005453-4057qib7 5104 7 have have VBP cord-005453-4057qib7 5104 8 a a DT cord-005453-4057qib7 5104 9 significant significant JJ cord-005453-4057qib7 5104 10 higher high JJR cord-005453-4057qib7 5104 11 CR cr NN cord-005453-4057qib7 5104 12 rate rate NN cord-005453-4057qib7 5104 13 than than IN cord-005453-4057qib7 5104 14 infected infected JJ cord-005453-4057qib7 5104 15 cohort cohort NN cord-005453-4057qib7 5104 16 ( ( -LRB- cord-005453-4057qib7 5104 17 92.6 92.6 CD cord-005453-4057qib7 5104 18 % % NN cord-005453-4057qib7 5104 19 vs. vs. IN cord-005453-4057qib7 5104 20 46.2 46.2 CD cord-005453-4057qib7 5104 21 % % NN cord-005453-4057qib7 5104 22 , , , cord-005453-4057qib7 5104 23 p=0.002 p=0.002 NNP cord-005453-4057qib7 5104 24 ) ) -RRB- cord-005453-4057qib7 5104 25 . . . cord-005453-4057qib7 5105 1 By by IN cord-005453-4057qib7 5105 2 logistic logistic JJ cord-005453-4057qib7 5105 3 regression regression NN cord-005453-4057qib7 5105 4 analysis analysis NN cord-005453-4057qib7 5105 5 , , , cord-005453-4057qib7 5105 6 the the DT cord-005453-4057qib7 5105 7 time time NN cord-005453-4057qib7 5105 8 from from IN cord-005453-4057qib7 5105 9 aGVHD aGVHD NNP cord-005453-4057qib7 5105 10 to to IN cord-005453-4057qib7 5105 11 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5105 12 ( ( -LRB- cord-005453-4057qib7 5105 13 RR=4.17 rr=4.17 UH cord-005453-4057qib7 5105 14 , , , cord-005453-4057qib7 5105 15 p=0.011 p=0.011 NNP cord-005453-4057qib7 5105 16 ) ) -RRB- cord-005453-4057qib7 5105 17 and and CC cord-005453-4057qib7 5105 18 gut gut VB cord-005453-4057qib7 5105 19 infection infection NN cord-005453-4057qib7 5105 20 ( ( -LRB- cord-005453-4057qib7 5105 21 RR=3.31 RR=3.31 NNS cord-005453-4057qib7 5105 22 , , , cord-005453-4057qib7 5105 23 p=0.031 p=0.031 NNP cord-005453-4057qib7 5105 24 ) ) -RRB- cord-005453-4057qib7 5105 25 were be VBD cord-005453-4057qib7 5105 26 independent independent JJ cord-005453-4057qib7 5105 27 predictors predictor NNS cord-005453-4057qib7 5105 28 for for IN cord-005453-4057qib7 5105 29 incomplete incomplete JJ cord-005453-4057qib7 5105 30 response response NN cord-005453-4057qib7 5105 31 . . . cord-005453-4057qib7 5106 1 Thirteen thirteen CD cord-005453-4057qib7 5106 2 patients patient NNS cord-005453-4057qib7 5106 3 ( ( -LRB- cord-005453-4057qib7 5106 4 13/40 13/40 CD cord-005453-4057qib7 5106 5 , , , cord-005453-4057qib7 5106 6 32.5 32.5 CD cord-005453-4057qib7 5106 7 % % NN cord-005453-4057qib7 5106 8 ) ) -RRB- cord-005453-4057qib7 5106 9 suffered suffer VBD cord-005453-4057qib7 5106 10 from from IN cord-005453-4057qib7 5106 11 at at RB cord-005453-4057qib7 5106 12 least least JJS cord-005453-4057qib7 5106 13 1 1 CD cord-005453-4057qib7 5106 14 infectious infectious JJ cord-005453-4057qib7 5106 15 episode episode NN cord-005453-4057qib7 5106 16 after after IN cord-005453-4057qib7 5106 17 the the DT cord-005453-4057qib7 5106 18 start start NN cord-005453-4057qib7 5106 19 of of IN cord-005453-4057qib7 5106 20 the the DT cord-005453-4057qib7 5106 21 combination combination NN cord-005453-4057qib7 5106 22 therapy therapy NN cord-005453-4057qib7 5106 23 , , , cord-005453-4057qib7 5106 24 and and CC cord-005453-4057qib7 5106 25 pulmonary pulmonary JJ cord-005453-4057qib7 5106 26 infectious infectious JJ cord-005453-4057qib7 5106 27 diseases disease NNS cord-005453-4057qib7 5106 28 was be VBD cord-005453-4057qib7 5106 29 a a DT cord-005453-4057qib7 5106 30 frequent frequent JJ cord-005453-4057qib7 5106 31 complication complication NN cord-005453-4057qib7 5106 32 ( ( -LRB- cord-005453-4057qib7 5106 33 9/40 9/40 CD cord-005453-4057qib7 5106 34 , , , cord-005453-4057qib7 5106 35 22.5 22.5 CD cord-005453-4057qib7 5106 36 % % NN cord-005453-4057qib7 5106 37 ) ) -RRB- cord-005453-4057qib7 5106 38 . . . cord-005453-4057qib7 5107 1 III III NNP cord-005453-4057qib7 5107 2 - - HYPH cord-005453-4057qib7 5107 3 IV IV NNP cord-005453-4057qib7 5107 4 Cytopenia Cytopenia NNP cord-005453-4057qib7 5107 5 and and CC cord-005453-4057qib7 5107 6 CMVreactivation CMVreactivation NNP cord-005453-4057qib7 5107 7 were be VBD cord-005453-4057qib7 5107 8 observed observe VBN cord-005453-4057qib7 5107 9 in in IN cord-005453-4057qib7 5107 10 30 30 CD cord-005453-4057qib7 5107 11 % % NN cord-005453-4057qib7 5107 12 and and CC cord-005453-4057qib7 5107 13 47.5 47.5 CD cord-005453-4057qib7 5107 14 % % NN cord-005453-4057qib7 5107 15 of of IN cord-005453-4057qib7 5107 16 patients patient NNS cord-005453-4057qib7 5107 17 . . . cord-005453-4057qib7 5108 1 The the DT cord-005453-4057qib7 5108 2 1-year 1-year CD cord-005453-4057qib7 5108 3 overall overall JJ cord-005453-4057qib7 5108 4 survival survival NN cord-005453-4057qib7 5108 5 ( ( -LRB- cord-005453-4057qib7 5108 6 OS OS NNP cord-005453-4057qib7 5108 7 ) ) -RRB- cord-005453-4057qib7 5108 8 after after IN cord-005453-4057qib7 5108 9 initiation initiation NN cord-005453-4057qib7 5108 10 of of IN cord-005453-4057qib7 5108 11 the the DT cord-005453-4057qib7 5108 12 combination combination NN cord-005453-4057qib7 5108 13 therapy therapy NN cord-005453-4057qib7 5108 14 were be VBD cord-005453-4057qib7 5108 15 76.8 76.8 CD cord-005453-4057qib7 5108 16 % % NN cord-005453-4057qib7 5108 17 . . . cord-005453-4057qib7 5109 1 The the DT cord-005453-4057qib7 5109 2 1-year 1-year CD cord-005453-4057qib7 5109 3 NRM NRM NNP cord-005453-4057qib7 5109 4 and and CC cord-005453-4057qib7 5109 5 relapse relapse NN cord-005453-4057qib7 5109 6 incidence incidence NN cord-005453-4057qib7 5109 7 was be VBD cord-005453-4057qib7 5109 8 17.9 17.9 CD cord-005453-4057qib7 5109 9 % % NN cord-005453-4057qib7 5109 10 and and CC cord-005453-4057qib7 5109 11 19.9 19.9 CD cord-005453-4057qib7 5109 12 % % NN cord-005453-4057qib7 5109 13 , , , cord-005453-4057qib7 5109 14 respectively respectively RB cord-005453-4057qib7 5109 15 . . . cord-005453-4057qib7 5110 1 Patients patient NNS cord-005453-4057qib7 5110 2 with with IN cord-005453-4057qib7 5110 3 complete complete JJ cord-005453-4057qib7 5110 4 response response NN cord-005453-4057qib7 5110 5 on on IN cord-005453-4057qib7 5110 6 day day NN cord-005453-4057qib7 5110 7 30 30 CD cord-005453-4057qib7 5110 8 had have VBD cord-005453-4057qib7 5110 9 significantly significantly RB cord-005453-4057qib7 5110 10 higher high JJR cord-005453-4057qib7 5110 11 OS OS NNP cord-005453-4057qib7 5110 12 probability probability NN cord-005453-4057qib7 5110 13 than than IN cord-005453-4057qib7 5110 14 non non JJ cord-005453-4057qib7 5110 15 - - JJ cord-005453-4057qib7 5110 16 CR cr JJ cord-005453-4057qib7 5110 17 patients patient NNS cord-005453-4057qib7 5110 18 ( ( -LRB- cord-005453-4057qib7 5110 19 1-year 1-year CD cord-005453-4057qib7 5110 20 OS os NN cord-005453-4057qib7 5110 21 : : : cord-005453-4057qib7 5110 22 86.1 86.1 CD cord-005453-4057qib7 5110 23 % % NN cord-005453-4057qib7 5110 24 vs vs IN cord-005453-4057qib7 5110 25 48.0 48.0 CD cord-005453-4057qib7 5110 26 % % NN cord-005453-4057qib7 5110 27 , , , cord-005453-4057qib7 5110 28 p=0.01 p=0.01 NNP cord-005453-4057qib7 5110 29 ) ) -RRB- cord-005453-4057qib7 5110 30 . . . cord-005453-4057qib7 5111 1 Compared compare VBN cord-005453-4057qib7 5111 2 with with IN cord-005453-4057qib7 5111 3 the the DT cord-005453-4057qib7 5111 4 historical historical JJ cord-005453-4057qib7 5111 5 cohort cohort NN cord-005453-4057qib7 5111 6 of of IN cord-005453-4057qib7 5111 7 basiliximab basiliximab NNP cord-005453-4057qib7 5111 8 and and CC cord-005453-4057qib7 5111 9 etanercept etanercept NNP cord-005453-4057qib7 5111 10 for for IN cord-005453-4057qib7 5111 11 SR SR NNP cord-005453-4057qib7 5111 12 - - HYPH cord-005453-4057qib7 5111 13 aGVHD aGVHD NNP cord-005453-4057qib7 5111 14 in in IN cord-005453-4057qib7 5111 15 our -PRON- PRP$ cord-005453-4057qib7 5111 16 center center NN cord-005453-4057qib7 5111 17 ( ( -LRB- cord-005453-4057qib7 5111 18 n=31 n=31 NNP cord-005453-4057qib7 5111 19 ) ) -RRB- cord-005453-4057qib7 5111 20 , , , cord-005453-4057qib7 5111 21 no no DT cord-005453-4057qib7 5111 22 significant significant JJ cord-005453-4057qib7 5111 23 difference difference NN cord-005453-4057qib7 5111 24 was be VBD cord-005453-4057qib7 5111 25 found find VBN cord-005453-4057qib7 5111 26 on on IN cord-005453-4057qib7 5111 27 the the DT cord-005453-4057qib7 5111 28 baseline baseline NN cord-005453-4057qib7 5111 29 . . . cord-005453-4057qib7 5112 1 Although although IN cord-005453-4057qib7 5112 2 the the DT cord-005453-4057qib7 5112 3 ORR ORR NNP cord-005453-4057qib7 5112 4 in in IN cord-005453-4057qib7 5112 5 patients patient NNS cord-005453-4057qib7 5112 6 treated treat VBN cord-005453-4057qib7 5112 7 with with IN cord-005453-4057qib7 5112 8 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5112 9 and and CC cord-005453-4057qib7 5112 10 etanercept etanercept NNP cord-005453-4057qib7 5112 11 is be VBZ cord-005453-4057qib7 5112 12 identical identical JJ cord-005453-4057qib7 5112 13 with with IN cord-005453-4057qib7 5112 14 the the DT cord-005453-4057qib7 5112 15 historical historical JJ cord-005453-4057qib7 5112 16 cohort cohort NN cord-005453-4057qib7 5112 17 , , , cord-005453-4057qib7 5112 18 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5112 19 group group NN cord-005453-4057qib7 5112 20 achieved achieve VBD cord-005453-4057qib7 5112 21 rapider rapider NN cord-005453-4057qib7 5112 22 remissions remission NNS cord-005453-4057qib7 5112 23 in in IN cord-005453-4057qib7 5112 24 liver liver NN cord-005453-4057qib7 5112 25 aGVHD agvhd NN cord-005453-4057qib7 5112 26 and and CC cord-005453-4057qib7 5112 27 gut gut VB cord-005453-4057qib7 5112 28 aGVHD agvhd NN cord-005453-4057qib7 5112 29 than than IN cord-005453-4057qib7 5112 30 the the DT cord-005453-4057qib7 5112 31 historical historical JJ cord-005453-4057qib7 5112 32 cohort cohort NN cord-005453-4057qib7 5112 33 ( ( -LRB- cord-005453-4057qib7 5112 34 gut gut VB cord-005453-4057qib7 5112 35 aGVHD agvhd NN cord-005453-4057qib7 5112 36 : : : cord-005453-4057qib7 5113 1 11 11 CD cord-005453-4057qib7 5113 2 days day NNS cord-005453-4057qib7 5113 3 vs. vs. IN cord-005453-4057qib7 5113 4 17 17 CD cord-005453-4057qib7 5113 5 days day NNS cord-005453-4057qib7 5113 6 , , , cord-005453-4057qib7 5113 7 p=0.026 p=0.026 NN cord-005453-4057qib7 5113 8 ; ; : cord-005453-4057qib7 5113 9 liver liver NNP cord-005453-4057qib7 5113 10 aGVHD aGVHD NNP cord-005453-4057qib7 5113 11 : : : cord-005453-4057qib7 5113 12 21 21 CD cord-005453-4057qib7 5113 13 days day NNS cord-005453-4057qib7 5113 14 vs. vs. IN cord-005453-4057qib7 5113 15 28 28 CD cord-005453-4057qib7 5113 16 days day NNS cord-005453-4057qib7 5113 17 , , , cord-005453-4057qib7 5113 18 p=0.039 p=0.039 NNP cord-005453-4057qib7 5113 19 ) ) -RRB- cord-005453-4057qib7 5113 20 , , . cord-005453-4057qib7 5114 1 Thus thus RB cord-005453-4057qib7 5114 2 , , , cord-005453-4057qib7 5114 3 with with IN cord-005453-4057qib7 5114 4 regard regard NN cord-005453-4057qib7 5114 5 to to IN cord-005453-4057qib7 5114 6 hospital hospital NN cord-005453-4057qib7 5114 7 stay stay NN cord-005453-4057qib7 5114 8 after after IN cord-005453-4057qib7 5114 9 aGVHD aGVHD NNP cord-005453-4057qib7 5114 10 onset onset NN cord-005453-4057qib7 5114 11 , , , cord-005453-4057qib7 5114 12 the the DT cord-005453-4057qib7 5114 13 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5114 14 cohort cohort NN cord-005453-4057qib7 5114 15 stayed stay VBD cord-005453-4057qib7 5114 16 shorter short JJR cord-005453-4057qib7 5114 17 ( ( -LRB- cord-005453-4057qib7 5114 18 median median NN cord-005453-4057qib7 5114 19 : : : cord-005453-4057qib7 5114 20 18 18 CD cord-005453-4057qib7 5114 21 days day NNS cord-005453-4057qib7 5114 22 vs. vs. IN cord-005453-4057qib7 5114 23 29 29 CD cord-005453-4057qib7 5114 24 days day NNS cord-005453-4057qib7 5114 25 , , , cord-005453-4057qib7 5114 26 p=0.005 p=0.005 NNP cord-005453-4057qib7 5114 27 ) ) -RRB- cord-005453-4057qib7 5114 28 than than IN cord-005453-4057qib7 5114 29 basiliximab basiliximab NNP cord-005453-4057qib7 5114 30 cohort cohort NN cord-005453-4057qib7 5114 31 . . . cord-005453-4057qib7 5115 1 Conclusions conclusion NNS cord-005453-4057qib7 5115 2 : : : cord-005453-4057qib7 5116 1 Combined combine VBN cord-005453-4057qib7 5116 2 treatment treatment NN cord-005453-4057qib7 5116 3 with with IN cord-005453-4057qib7 5116 4 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5116 5 and and CC cord-005453-4057qib7 5116 6 etanercept etanercept NNP cord-005453-4057qib7 5116 7 resulted result VBD cord-005453-4057qib7 5116 8 in in IN cord-005453-4057qib7 5116 9 a a DT cord-005453-4057qib7 5116 10 rapid rapid JJ cord-005453-4057qib7 5116 11 CR cr NN cord-005453-4057qib7 5116 12 to to IN cord-005453-4057qib7 5116 13 visceral visceral JJ cord-005453-4057qib7 5116 14 aGVHD agvhd NN cord-005453-4057qib7 5117 1 and and CC cord-005453-4057qib7 5117 2 meanwhile meanwhile RB cord-005453-4057qib7 5117 3 reserve reserve VB cord-005453-4057qib7 5117 4 graft graft NN cord-005453-4057qib7 5117 5 anti anti NN cord-005453-4057qib7 5117 6 - - JJ cord-005453-4057qib7 5117 7 leukemia leukemia JJ cord-005453-4057qib7 5117 8 ( ( -LRB- cord-005453-4057qib7 5117 9 GVL gvl NN cord-005453-4057qib7 5117 10 ) ) -RRB- cord-005453-4057qib7 5117 11 effect effect NN cord-005453-4057qib7 5117 12 as as IN cord-005453-4057qib7 5117 13 the the DT cord-005453-4057qib7 5117 14 relapse relapse NN cord-005453-4057qib7 5117 15 rate rate NN cord-005453-4057qib7 5117 16 of of IN cord-005453-4057qib7 5117 17 primary primary JJ cord-005453-4057qib7 5117 18 disease disease NN cord-005453-4057qib7 5117 19 is be VBZ cord-005453-4057qib7 5117 20 relatively relatively RB cord-005453-4057qib7 5117 21 lower low JJR cord-005453-4057qib7 5117 22 . . . cord-005453-4057qib7 5118 1 The the DT cord-005453-4057qib7 5118 2 various various JJ cord-005453-4057qib7 5118 3 infection infection NN cord-005453-4057qib7 5118 4 complications complication NNS cord-005453-4057qib7 5118 5 associated associate VBN cord-005453-4057qib7 5118 6 with with IN cord-005453-4057qib7 5118 7 ruxolitinib ruxolitinib JJ cord-005453-4057qib7 5118 8 merit merit NN cord-005453-4057qib7 5118 9 more more JJR cord-005453-4057qib7 5118 10 attention attention NN cord-005453-4057qib7 5118 11 . . . cord-005453-4057qib7 5119 1 Disclosure disclosure NN cord-005453-4057qib7 5119 2 : : : cord-005453-4057qib7 5119 3 Nothing nothing NN cord-005453-4057qib7 5119 4 to to TO cord-005453-4057qib7 5119 5 declare declare VB cord-005453-4057qib7 5119 6 Background background NN cord-005453-4057qib7 5119 7 : : : cord-005453-4057qib7 5119 8 Graft graft NN cord-005453-4057qib7 5119 9 - - HYPH cord-005453-4057qib7 5119 10 versus versus IN cord-005453-4057qib7 5119 11 - - HYPH cord-005453-4057qib7 5119 12 host host NN cord-005453-4057qib7 5119 13 disease disease NN cord-005453-4057qib7 5119 14 ( ( -LRB- cord-005453-4057qib7 5119 15 GVHD GVHD NNP cord-005453-4057qib7 5119 16 ) ) -RRB- cord-005453-4057qib7 5119 17 remains remain VBZ cord-005453-4057qib7 5119 18 one one CD cord-005453-4057qib7 5119 19 of of IN cord-005453-4057qib7 5119 20 the the DT cord-005453-4057qib7 5119 21 main main JJ cord-005453-4057qib7 5119 22 life life NN cord-005453-4057qib7 5119 23 - - HYPH cord-005453-4057qib7 5119 24 threatening threaten VBG cord-005453-4057qib7 5119 25 complications complication NNS cord-005453-4057qib7 5119 26 after after IN cord-005453-4057qib7 5119 27 allo allo NN cord-005453-4057qib7 5119 28 - - HYPH cord-005453-4057qib7 5119 29 HSCT HSCT NNP cord-005453-4057qib7 5119 30 , , , cord-005453-4057qib7 5119 31 especially especially RB cord-005453-4057qib7 5119 32 in in IN cord-005453-4057qib7 5119 33 patients patient NNS cord-005453-4057qib7 5119 34 with with IN cord-005453-4057qib7 5119 35 non non JJ cord-005453-4057qib7 5119 36 - - JJ cord-005453-4057qib7 5119 37 malignant malignant JJ cord-005453-4057qib7 5119 38 diseases disease NNS cord-005453-4057qib7 5119 39 . . . cord-005453-4057qib7 5120 1 The the DT cord-005453-4057qib7 5120 2 standard standard JJ cord-005453-4057qib7 5120 3 GVHD GVHD NNP cord-005453-4057qib7 5120 4 prophylaxis prophylaxis NN cord-005453-4057qib7 5120 5 strategy strategy NN cord-005453-4057qib7 5120 6 is be VBZ cord-005453-4057qib7 5120 7 mostly mostly RB cord-005453-4057qib7 5120 8 based base VBN cord-005453-4057qib7 5120 9 on on IN cord-005453-4057qib7 5120 10 the the DT cord-005453-4057qib7 5120 11 use use NN cord-005453-4057qib7 5120 12 of of IN cord-005453-4057qib7 5120 13 calcineurin calcineurin NN cord-005453-4057qib7 5120 14 inhibitors inhibitor NNS cord-005453-4057qib7 5120 15 alone alone RB cord-005453-4057qib7 5120 16 or or CC cord-005453-4057qib7 5120 17 in in IN cord-005453-4057qib7 5120 18 combination combination NN cord-005453-4057qib7 5120 19 with with IN cord-005453-4057qib7 5120 20 other other JJ cord-005453-4057qib7 5120 21 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 5121 1 ( ( -LRB- cord-005453-4057qib7 5121 2 IS be VBZ cord-005453-4057qib7 5121 3 ) ) -RRB- cord-005453-4057qib7 5121 4 Post post JJ cord-005453-4057qib7 5121 5 - - NN cord-005453-4057qib7 5121 6 transplant transplant NN cord-005453-4057qib7 5121 7 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 5121 8 ( ( -LRB- cord-005453-4057qib7 5121 9 PTCy PTCy NNP cord-005453-4057qib7 5121 10 ) ) -RRB- cord-005453-4057qib7 5121 11 is be VBZ cord-005453-4057qib7 5121 12 effective effective JJ cord-005453-4057qib7 5121 13 GVHD GVHD NNP cord-005453-4057qib7 5121 14 prophylaxis prophylaxis NN cord-005453-4057qib7 5121 15 optiont optiont NN cord-005453-4057qib7 5121 16 for for IN cord-005453-4057qib7 5121 17 adult adult NN cord-005453-4057qib7 5121 18 patients patient NNS cord-005453-4057qib7 5121 19 ( ( -LRB- cord-005453-4057qib7 5121 20 pts pts NNP cord-005453-4057qib7 5121 21 ) ) -RRB- cord-005453-4057qib7 5121 22 , , , cord-005453-4057qib7 5121 23 but but CC cord-005453-4057qib7 5121 24 has have VBZ cord-005453-4057qib7 5121 25 limited limit VBN cord-005453-4057qib7 5121 26 data datum NNS cord-005453-4057qib7 5121 27 in in IN cord-005453-4057qib7 5121 28 children child NNS cord-005453-4057qib7 5121 29 . . . cord-005453-4057qib7 5122 1 Methods method NNS cord-005453-4057qib7 5122 2 : : : cord-005453-4057qib7 5123 1 The the DT cord-005453-4057qib7 5123 2 study study NN cord-005453-4057qib7 5123 3 aim aim NN cord-005453-4057qib7 5123 4 was be VBD cord-005453-4057qib7 5123 5 to to TO cord-005453-4057qib7 5123 6 evaluate evaluate VB cord-005453-4057qib7 5123 7 PTCy PTCy NNS cord-005453-4057qib7 5123 8 as as IN cord-005453-4057qib7 5123 9 GVHD GVHD NNP cord-005453-4057qib7 5123 10 prophylaxis prophylaxis NN cord-005453-4057qib7 5123 11 in in IN cord-005453-4057qib7 5123 12 pediatric pediatric JJ cord-005453-4057qib7 5123 13 pts pts NN cord-005453-4057qib7 5123 14 with with IN cord-005453-4057qib7 5123 15 inherited inherit VBN cord-005453-4057qib7 5123 16 disorders disorder NNS cord-005453-4057qib7 5123 17 undergoing undergo VBG cord-005453-4057qib7 5123 18 allo allo NN cord-005453-4057qib7 5123 19 - - HYPH cord-005453-4057qib7 5123 20 HSCT HSCT NNP cord-005453-4057qib7 5123 21 . . . cord-005453-4057qib7 5124 1 96 96 CD cord-005453-4057qib7 5124 2 pts pt NNS cord-005453-4057qib7 5124 3 , , , cord-005453-4057qib7 5124 4 the the DT cord-005453-4057qib7 5124 5 most most JJS cord-005453-4057qib7 5124 6 of of IN cord-005453-4057qib7 5124 7 them -PRON- PRP cord-005453-4057qib7 5124 8 are be VBP cord-005453-4057qib7 5124 9 pediatric pediatric JJ cord-005453-4057qib7 5124 10 age age NN cord-005453-4057qib7 5124 11 ( ( -LRB- cord-005453-4057qib7 5124 12 median median JJ cord-005453-4057qib7 5124 13 age age NN cord-005453-4057qib7 5124 14 -3 -3 NNP cord-005453-4057qib7 5125 1 y.o y.o NNP cord-005453-4057qib7 5125 2 . . NNP cord-005453-4057qib7 5125 3 , , , cord-005453-4057qib7 5125 4 range range NNP cord-005453-4057qib7 5125 5 7 7 CD cord-005453-4057qib7 5125 6 month month NN cord-005453-4057qib7 5126 1 -30 -30 NNP cord-005453-4057qib7 5127 1 y.o y.o NNP cord-005453-4057qib7 5127 2 . . NNP cord-005453-4057qib7 5127 3 ) ) -RRB- cord-005453-4057qib7 5128 1 with with IN cord-005453-4057qib7 5128 2 different different JJ cord-005453-4057qib7 5128 3 types type NNS cord-005453-4057qib7 5128 4 inherited inherit VBN cord-005453-4057qib7 5128 5 disorders disorder NNS cord-005453-4057qib7 5128 6 ( ( -LRB- cord-005453-4057qib7 5128 7 β β NN cord-005453-4057qib7 5128 8 - - HYPH cord-005453-4057qib7 5128 9 thalassemia thalassemia NN cord-005453-4057qib7 5128 10 -10 -10 NN cord-005453-4057qib7 5128 11 , , , cord-005453-4057qib7 5128 12 bone bone NN cord-005453-4057qib7 5128 13 marrow marrow NN cord-005453-4057qib7 5128 14 failure failure NN cord-005453-4057qib7 5128 15 syndromes syndrome NNS cord-005453-4057qib7 5128 16 -26 -26 CD cord-005453-4057qib7 5128 17 , , , cord-005453-4057qib7 5128 18 storage storage NN cord-005453-4057qib7 5128 19 diseases disease NNS cord-005453-4057qib7 5128 20 -46 -46 NN cord-005453-4057qib7 5128 21 , , , cord-005453-4057qib7 5128 22 primary primary JJ cord-005453-4057qib7 5128 23 immunodeficiencydisorders immunodeficiencydisorder NNS cord-005453-4057qib7 5128 24 -14 -14 CD cord-005453-4057qib7 5128 25 ) ) -RRB- cord-005453-4057qib7 5128 26 were be VBD cord-005453-4057qib7 5128 27 inrolled inrolle VBN cord-005453-4057qib7 5128 28 in in IN cord-005453-4057qib7 5128 29 retrospective retrospective JJ cord-005453-4057qib7 5128 30 study study NN cord-005453-4057qib7 5128 31 . . . cord-005453-4057qib7 5129 1 Donor donor NN cord-005453-4057qib7 5129 2 type type NN cord-005453-4057qib7 5129 3 was be VBD cord-005453-4057qib7 5129 4 : : : cord-005453-4057qib7 5129 5 matched match VBN cord-005453-4057qib7 5129 6 / / SYM cord-005453-4057qib7 5129 7 mismatched mismatch VBN cord-005453-4057qib7 5129 8 unrelated unrelated JJ cord-005453-4057qib7 5129 9 ( ( -LRB- cord-005453-4057qib7 5129 10 MUD mud NN cord-005453-4057qib7 5129 11 / / SYM cord-005453-4057qib7 5129 12 MMUD MMUD NNP cord-005453-4057qib7 5129 13 ) ) -RRB- cord-005453-4057qib7 5129 14 -69 -69 NNP cord-005453-4057qib7 5129 15 , , , cord-005453-4057qib7 5129 16 matched match VBD cord-005453-4057qib7 5129 17 related related JJ cord-005453-4057qib7 5129 18 donor donor NN cord-005453-4057qib7 5129 19 ( ( -LRB- cord-005453-4057qib7 5129 20 MRD)-15 MRD)-15 NNP cord-005453-4057qib7 5129 21 , , , cord-005453-4057qib7 5129 22 haploidentical haploidentical NNP cord-005453-4057qib7 5129 23 ( ( -LRB- cord-005453-4057qib7 5129 24 haplo haplo NNP cord-005453-4057qib7 5129 25 ) ) -RRB- cord-005453-4057qib7 5129 26 -12 -12 CD cord-005453-4057qib7 5129 27 . . . cord-005453-4057qib7 5130 1 Conditioning conditioning NN cord-005453-4057qib7 5130 2 regimen regimen NN cord-005453-4057qib7 5130 3 was be VBD cord-005453-4057qib7 5130 4 : : : cord-005453-4057qib7 5130 5 myeloablative myeloablative NNP cord-005453-4057qib7 5130 6 ( ( -LRB- cord-005453-4057qib7 5130 7 MAC MAC NNP cord-005453-4057qib7 5130 8 ) ) -RRB- cord-005453-4057qib7 5130 9 -43 -43 NN cord-005453-4057qib7 5130 10 , , , cord-005453-4057qib7 5131 1 reduce reduce VB cord-005453-4057qib7 5131 2 - - HYPH cord-005453-4057qib7 5131 3 intensity intensity NN cord-005453-4057qib7 5131 4 ( ( -LRB- cord-005453-4057qib7 5131 5 RIC RIC NNP cord-005453-4057qib7 5131 6 ) ) -RRB- cord-005453-4057qib7 5131 7 -53 -53 NNP cord-005453-4057qib7 5131 8 . . . cord-005453-4057qib7 5132 1 Graft graft NN cord-005453-4057qib7 5132 2 sourse sourse NN cord-005453-4057qib7 5132 3 was be VBD cord-005453-4057qib7 5132 4 : : : cord-005453-4057qib7 5132 5 bone bone NN cord-005453-4057qib7 5132 6 marrow marrow NN cord-005453-4057qib7 5132 7 ( ( -LRB- cord-005453-4057qib7 5132 8 BM BM NNP cord-005453-4057qib7 5132 9 ) ) -RRB- cord-005453-4057qib7 5132 10 -68 -68 NNP cord-005453-4057qib7 5132 11 , , , cord-005453-4057qib7 5132 12 peripheral peripheral JJ cord-005453-4057qib7 5132 13 blood blood NN cord-005453-4057qib7 5132 14 stem stem NN cord-005453-4057qib7 5132 15 cells cell NNS cord-005453-4057qib7 5132 16 ( ( -LRB- cord-005453-4057qib7 5132 17 PBSC PBSC NNP cord-005453-4057qib7 5132 18 ) ) -RRB- cord-005453-4057qib7 5132 19 -26 -26 CD cord-005453-4057qib7 5132 20 , , , cord-005453-4057qib7 5132 21 combintions combintion NNS cord-005453-4057qib7 5132 22 BM BM NNP cord-005453-4057qib7 5132 23 + + CC cord-005453-4057qib7 5132 24 PBSC PBSC NNP cord-005453-4057qib7 5132 25 / / SYM cord-005453-4057qib7 5132 26 BM+cord BM+cord NNP cord-005453-4057qib7 5132 27 blood blood NN cord-005453-4057qib7 5132 28 -2 -2 CD cord-005453-4057qib7 5132 29 . . . cord-005453-4057qib7 5133 1 PTCy PTCy NNS cord-005453-4057qib7 5133 2 50 50 CD cord-005453-4057qib7 5134 1 mg mg NNP cord-005453-4057qib7 5134 2 / / SYM cord-005453-4057qib7 5134 3 kg kg NNP cord-005453-4057qib7 5134 4 days day NNS cord-005453-4057qib7 5134 5 +3 +3 NNP cord-005453-4057qib7 5134 6 , , , cord-005453-4057qib7 5134 7 +4 +4 FW cord-005453-4057qib7 5134 8 based base VBN cord-005453-4057qib7 5134 9 GVHD GVHD NNP cord-005453-4057qib7 5134 10 prophylaxis prophylaxis NN cord-005453-4057qib7 5134 11 recived recive VBD cord-005453-4057qib7 5134 12 33 33 CD cord-005453-4057qib7 5134 13 pts pt NNS cord-005453-4057qib7 5134 14 . . . cord-005453-4057qib7 5135 1 , , , cord-005453-4057qib7 5135 2 standart standart NNP cord-005453-4057qib7 5135 3 GVHD GVHD NNP cord-005453-4057qib7 5135 4 prophylaxis prophylaxis NN cord-005453-4057qib7 5135 5 based base VBN cord-005453-4057qib7 5135 6 on on IN cord-005453-4057qib7 5135 7 calcineurin calcineurin NNP cord-005453-4057qib7 5135 8 inhibitors inhibitor NNS cord-005453-4057qib7 5135 9 -63 -63 NNP cord-005453-4057qib7 5135 10 pts pt NNS cord-005453-4057qib7 5135 11 . . . cord-005453-4057qib7 5136 1 Results result NNS cord-005453-4057qib7 5136 2 : : : cord-005453-4057qib7 5137 1 Cumulative cumulative JJ cord-005453-4057qib7 5137 2 incidence incidence NN cord-005453-4057qib7 5137 3 ( ( -LRB- cord-005453-4057qib7 5137 4 CI CI NNP cord-005453-4057qib7 5137 5 ) ) -RRB- cord-005453-4057qib7 5137 6 of of IN cord-005453-4057qib7 5137 7 aGVHD aGVHD NNP cord-005453-4057qib7 5137 8 was be VBD cord-005453-4057qib7 5137 9 48 48 CD cord-005453-4057qib7 5137 10 % % NN cord-005453-4057qib7 5137 11 . . . cord-005453-4057qib7 5138 1 Grade grade NN cord-005453-4057qib7 5138 2 2 2 CD cord-005453-4057qib7 5138 3 - - SYM cord-005453-4057qib7 5138 4 4 4 CD cord-005453-4057qib7 5138 5 , , , cord-005453-4057qib7 5138 6 3 3 CD cord-005453-4057qib7 5138 7 - - SYM cord-005453-4057qib7 5138 8 4 4 CD cord-005453-4057qib7 5138 9 aGVHD aGVHD NNP cord-005453-4057qib7 5138 10 were be VBD cord-005453-4057qib7 5138 11 40 40 CD cord-005453-4057qib7 5138 12 % % NN cord-005453-4057qib7 5138 13 and and CC cord-005453-4057qib7 5138 14 22 22 CD cord-005453-4057qib7 5138 15 % % NN cord-005453-4057qib7 5138 16 respectively respectively RB cord-005453-4057qib7 5138 17 . . . cord-005453-4057qib7 5139 1 PTCy PTCy NNP cord-005453-4057qib7 5139 2 based base VBN cord-005453-4057qib7 5139 3 GVHD GVHD NNP cord-005453-4057qib7 5139 4 prophylaxis prophylaxis NN cord-005453-4057qib7 5139 5 reduced reduce VBN cord-005453-4057qib7 5139 6 CI CI NNP cord-005453-4057qib7 5139 7 of of IN cord-005453-4057qib7 5139 8 aGVHD aGVHD NNP cord-005453-4057qib7 5139 9 ( ( -LRB- cord-005453-4057qib7 5139 10 35 35 CD cord-005453-4057qib7 5139 11 % % NN cord-005453-4057qib7 5139 12 vs vs IN cord-005453-4057qib7 5139 13 56 56 CD cord-005453-4057qib7 5139 14 % % NN cord-005453-4057qib7 5139 15 , , , cord-005453-4057qib7 5139 16 p=0,025 p=0,025 NNP cord-005453-4057qib7 5139 17 ) ) -RRB- cord-005453-4057qib7 5139 18 . . . cord-005453-4057qib7 5140 1 Another another DT cord-005453-4057qib7 5140 2 reduce reduce NN cord-005453-4057qib7 5140 3 CI CI NNP cord-005453-4057qib7 5140 4 of of IN cord-005453-4057qib7 5140 5 aGVHD aGVHD NNP cord-005453-4057qib7 5140 6 factors factor NNS cord-005453-4057qib7 5141 1 were be VBD cord-005453-4057qib7 5141 2 MAC MAC NNP cord-005453-4057qib7 5141 3 ( ( -LRB- cord-005453-4057qib7 5141 4 31 31 CD cord-005453-4057qib7 5141 5 % % NN cord-005453-4057qib7 5141 6 vs vs IN cord-005453-4057qib7 5141 7 59 59 CD cord-005453-4057qib7 5141 8 % % NN cord-005453-4057qib7 5141 9 in in IN cord-005453-4057qib7 5141 10 RIC RIC NNP cord-005453-4057qib7 5141 11 pts pts NNP cord-005453-4057qib7 5141 12 group group NN cord-005453-4057qib7 5141 13 , , , cord-005453-4057qib7 5141 14 p=0,044 p=0,044 NNP cord-005453-4057qib7 5141 15 ) ) -RRB- cord-005453-4057qib7 5141 16 , , , cord-005453-4057qib7 5141 17 MRD MRD NNP cord-005453-4057qib7 5141 18 ( ( -LRB- cord-005453-4057qib7 5141 19 13 13 CD cord-005453-4057qib7 5141 20 % % NN cord-005453-4057qib7 5141 21 vs vs IN cord-005453-4057qib7 5141 22 44 44 CD cord-005453-4057qib7 5141 23 % % NN cord-005453-4057qib7 5141 24 in in IN cord-005453-4057qib7 5141 25 haplo haplo NNP cord-005453-4057qib7 5141 26 group group NN cord-005453-4057qib7 5141 27 vs vs IN cord-005453-4057qib7 5141 28 56 56 CD cord-005453-4057qib7 5141 29 % % NN cord-005453-4057qib7 5141 30 in in IN cord-005453-4057qib7 5141 31 MUD MUD NNP cord-005453-4057qib7 5141 32 / / SYM cord-005453-4057qib7 5141 33 MMUD MMUD NNP cord-005453-4057qib7 5141 34 group group NN cord-005453-4057qib7 5141 35 , , , cord-005453-4057qib7 5141 36 p=0,024 p=0,024 NNP cord-005453-4057qib7 5141 37 ) ) -RRB- cord-005453-4057qib7 5141 38 , , , cord-005453-4057qib7 5141 39 BM BM NNP cord-005453-4057qib7 5141 40 as as IN cord-005453-4057qib7 5141 41 a a DT cord-005453-4057qib7 5141 42 transplant transplant NN cord-005453-4057qib7 5141 43 source source NN cord-005453-4057qib7 5141 44 ( ( -LRB- cord-005453-4057qib7 5141 45 44 44 CD cord-005453-4057qib7 5141 46 % % NN cord-005453-4057qib7 5141 47 vs vs IN cord-005453-4057qib7 5141 48 62 62 CD cord-005453-4057qib7 5141 49 % % NN cord-005453-4057qib7 5141 50 in in IN cord-005453-4057qib7 5141 51 PBSC PBSC NNP cord-005453-4057qib7 5141 52 group group NN cord-005453-4057qib7 5141 53 , , , cord-005453-4057qib7 5141 54 p=0,05 p=0,05 NNP cord-005453-4057qib7 5141 55 ) ) -RRB- cord-005453-4057qib7 5141 56 . . . cord-005453-4057qib7 5142 1 In in IN cord-005453-4057qib7 5142 2 a a DT cord-005453-4057qib7 5142 3 multivariate multivariate JJ cord-005453-4057qib7 5142 4 analysis analysis NN cord-005453-4057qib7 5142 5 MAC mac NN cord-005453-4057qib7 5143 1 ( ( -LRB- cord-005453-4057qib7 5143 2 HR HR NNP cord-005453-4057qib7 5143 3 2,6 2,6 CD cord-005453-4057qib7 5143 4 95%CI 95%ci CD cord-005453-4057qib7 5143 5 1,7 1,7 CD cord-005453-4057qib7 5143 6 - - HYPH cord-005453-4057qib7 5143 7 6 6 CD cord-005453-4057qib7 5143 8 , , , cord-005453-4057qib7 5143 9 , , , cord-005453-4057qib7 5143 10 p=0,02 p=0,02 NNP cord-005453-4057qib7 5143 11 ) ) -RRB- cord-005453-4057qib7 5143 12 , , , cord-005453-4057qib7 5143 13 time time NN cord-005453-4057qib7 5143 14 from from IN cord-005453-4057qib7 5143 15 diagnosis diagnosis NN cord-005453-4057qib7 5143 16 to to IN cord-005453-4057qib7 5143 17 allo allo NN cord-005453-4057qib7 5143 18 - - HYPH cord-005453-4057qib7 5143 19 HSCT HSCT NNP cord-005453-4057qib7 5143 20 less less RBR cord-005453-4057qib7 5143 21 then then RB cord-005453-4057qib7 5143 22 22 22 CD cord-005453-4057qib7 5143 23 month month NN cord-005453-4057qib7 5143 24 ( ( -LRB- cord-005453-4057qib7 5143 25 HR HR NNP cord-005453-4057qib7 5143 26 2,6 2,6 CD cord-005453-4057qib7 5143 27 95%CI 95%ci CD cord-005453-4057qib7 5143 28 1,1 1,1 CD cord-005453-4057qib7 5143 29 - - HYPH cord-005453-4057qib7 5143 30 6,2 6,2 CD cord-005453-4057qib7 5143 31 , , , cord-005453-4057qib7 5143 32 p=0,03 p=0,03 NNP cord-005453-4057qib7 5143 33 ) ) -RRB- cord-005453-4057qib7 5143 34 were be VBD cord-005453-4057qib7 5143 35 predictive predictive JJ cord-005453-4057qib7 5143 36 for for IN cord-005453-4057qib7 5143 37 reducing reduce VBG cord-005453-4057qib7 5143 38 CI CI NNP cord-005453-4057qib7 5143 39 aGVHD aGVHD NNP cord-005453-4057qib7 5143 40 . . . cord-005453-4057qib7 5144 1 For for IN cord-005453-4057qib7 5144 2 aGVHD aGVHD NNP cord-005453-4057qib7 5144 3 2 2 CD cord-005453-4057qib7 5144 4 - - SYM cord-005453-4057qib7 5144 5 4 4 CD cord-005453-4057qib7 5144 6 st st NNP cord-005453-4057qib7 5144 7 . . NNP cord-005453-4057qib7 5144 8 significant significant JJ cord-005453-4057qib7 5144 9 factor factor NN cord-005453-4057qib7 5144 10 increase increase NN cord-005453-4057qib7 5145 1 CI CI NNP cord-005453-4057qib7 5145 2 was be VBD cord-005453-4057qib7 5145 3 female female JJ cord-005453-4057qib7 5145 4 donor donor NN cord-005453-4057qib7 5145 5 both both CC cord-005453-4057qib7 5145 6 in in IN cord-005453-4057qib7 5145 7 univariate univariate JJ cord-005453-4057qib7 5145 8 ( ( -LRB- cord-005453-4057qib7 5145 9 51 51 CD cord-005453-4057qib7 5145 10 % % NN cord-005453-4057qib7 5145 11 vs vs IN cord-005453-4057qib7 5145 12 34 34 CD cord-005453-4057qib7 5145 13 % % NN cord-005453-4057qib7 5145 14 , , , cord-005453-4057qib7 5145 15 p=0,04 p=0,04 NNP cord-005453-4057qib7 5145 16 ) ) -RRB- cord-005453-4057qib7 5145 17 and and CC cord-005453-4057qib7 5145 18 multivariate multivariate JJ cord-005453-4057qib7 5145 19 analysis analysis NN cord-005453-4057qib7 5145 20 ( ( -LRB- cord-005453-4057qib7 5146 1 HR HR NNP cord-005453-4057qib7 5146 2 0,7 0,7 CD cord-005453-4057qib7 5147 1 95%CI 95%ci CD cord-005453-4057qib7 5147 2 0,2 0,2 CD cord-005453-4057qib7 5147 3 - - HYPH cord-005453-4057qib7 5147 4 0,8 0,8 CD cord-005453-4057qib7 5148 1 , , , cord-005453-4057qib7 5148 2 p=0,02).5 p=0,02).5 CD cord-005453-4057qib7 5148 3 years year NNS cord-005453-4057qib7 5148 4 overall overall JJ cord-005453-4057qib7 5148 5 survival survival NN cord-005453-4057qib7 5148 6 ( ( -LRB- cord-005453-4057qib7 5148 7 OS OS NNP cord-005453-4057qib7 5148 8 ) ) -RRB- cord-005453-4057qib7 5148 9 was be VBD cord-005453-4057qib7 5148 10 60 60 CD cord-005453-4057qib7 5148 11 % % NN cord-005453-4057qib7 5148 12 . . . cord-005453-4057qib7 5149 1 Improving improve VBG cord-005453-4057qib7 5149 2 OS os NN cord-005453-4057qib7 5149 3 factors factor NNS cord-005453-4057qib7 5149 4 were be VBD cord-005453-4057qib7 5149 5 : : : cord-005453-4057qib7 5150 1 transplant transplant NN cord-005453-4057qib7 5150 2 age age NN cord-005453-4057qib7 5150 3 younger young JJR cord-005453-4057qib7 5151 1 then then RB cord-005453-4057qib7 5151 2 5 5 CD cord-005453-4057qib7 5152 1 y.o y.o NNP cord-005453-4057qib7 5152 2 . . . cord-005453-4057qib7 5153 1 ( ( -LRB- cord-005453-4057qib7 5153 2 80 80 CD cord-005453-4057qib7 5153 3 % % NN cord-005453-4057qib7 5153 4 vs vs IN cord-005453-4057qib7 5153 5 35 35 CD cord-005453-4057qib7 5153 6 % % NN cord-005453-4057qib7 5153 7 , , , cord-005453-4057qib7 5153 8 p=0,000 p=0,000 NNP cord-005453-4057qib7 5153 9 ) ) -RRB- cord-005453-4057qib7 5153 10 , , , cord-005453-4057qib7 5153 11 time time NN cord-005453-4057qib7 5153 12 from from IN cord-005453-4057qib7 5153 13 diagnosis diagnosis NN cord-005453-4057qib7 5153 14 to to IN cord-005453-4057qib7 5153 15 allo allo NN cord-005453-4057qib7 5153 16 - - HYPH cord-005453-4057qib7 5153 17 HSCT HSCT NNP cord-005453-4057qib7 5153 18 less less RBR cord-005453-4057qib7 5153 19 then then RB cord-005453-4057qib7 5153 20 22 22 CD cord-005453-4057qib7 5153 21 month month NN cord-005453-4057qib7 5153 22 ( ( -LRB- cord-005453-4057qib7 5153 23 72 72 CD cord-005453-4057qib7 5153 24 % % NN cord-005453-4057qib7 5153 25 vs vs IN cord-005453-4057qib7 5153 26 38 38 CD cord-005453-4057qib7 5153 27 % % NN cord-005453-4057qib7 5153 28 , , , cord-005453-4057qib7 5153 29 p=0,000 p=0,000 NNP cord-005453-4057qib7 5153 30 ) ) -RRB- cord-005453-4057qib7 5153 31 , , , cord-005453-4057qib7 5153 32 engraftment engraftment NNP cord-005453-4057qib7 5153 33 ( ( -LRB- cord-005453-4057qib7 5153 34 72 72 CD cord-005453-4057qib7 5153 35 % % NN cord-005453-4057qib7 5153 36 vs vs IN cord-005453-4057qib7 5153 37 22 22 CD cord-005453-4057qib7 5153 38 % % NN cord-005453-4057qib7 5153 39 , , , cord-005453-4057qib7 5153 40 p=0,000 p=0,000 NNP cord-005453-4057qib7 5153 41 ) ) -RRB- cord-005453-4057qib7 5153 42 . . . cord-005453-4057qib7 5154 1 In in IN cord-005453-4057qib7 5154 2 a a DT cord-005453-4057qib7 5154 3 multivariate multivariate JJ cord-005453-4057qib7 5154 4 analysis analysis NN cord-005453-4057qib7 5154 5 only only RB cord-005453-4057qib7 5154 6 transplant transplant NN cord-005453-4057qib7 5154 7 age age NN cord-005453-4057qib7 5155 1 younger young JJR cord-005453-4057qib7 5156 1 then then RB cord-005453-4057qib7 5156 2 5 5 CD cord-005453-4057qib7 5157 1 y.o y.o NNP cord-005453-4057qib7 5157 2 . . . cord-005453-4057qib7 5158 1 ( ( -LRB- cord-005453-4057qib7 5158 2 HR HR NNP cord-005453-4057qib7 5158 3 3 3 CD cord-005453-4057qib7 5158 4 , , , cord-005453-4057qib7 5158 5 3 3 CD cord-005453-4057qib7 5158 6 95%CI 95%ci CD cord-005453-4057qib7 5158 7 1 1 CD cord-005453-4057qib7 5158 8 , , , cord-005453-4057qib7 5158 9 ( ( -LRB- cord-005453-4057qib7 5158 10 4 4 LS cord-005453-4057qib7 5158 11 ) ) -RRB- cord-005453-4057qib7 5158 12 ( ( -LRB- cord-005453-4057qib7 5158 13 5 5 LS cord-005453-4057qib7 5158 14 ) ) -RRB- cord-005453-4057qib7 5158 15 ( ( -LRB- cord-005453-4057qib7 5158 16 6 6 LS cord-005453-4057qib7 5158 17 ) ) -RRB- cord-005453-4057qib7 5158 18 ( ( -LRB- cord-005453-4057qib7 5158 19 7 7 LS cord-005453-4057qib7 5158 20 ) ) -RRB- cord-005453-4057qib7 5158 21 ( ( -LRB- cord-005453-4057qib7 5158 22 8) 8) NNP cord-005453-4057qib7 5158 23 p=0 p=0 NNP cord-005453-4057qib7 5158 24 , , , cord-005453-4057qib7 5158 25 006 006 CD cord-005453-4057qib7 5158 26 ) ) -RRB- cord-005453-4057qib7 5158 27 and and CC cord-005453-4057qib7 5158 28 engraftment engraftment NNP cord-005453-4057qib7 5158 29 ( ( -LRB- cord-005453-4057qib7 5158 30 HR hr NN cord-005453-4057qib7 5158 31 0,3 0,3 CD cord-005453-4057qib7 5158 32 95%CI 95%ci CD cord-005453-4057qib7 5158 33 0,1 0,1 CD cord-005453-4057qib7 5158 34 - - HYPH cord-005453-4057qib7 5158 35 0,7 0,7 CD cord-005453-4057qib7 5158 36 , , , cord-005453-4057qib7 5158 37 p=0,005 p=0,005 NNP cord-005453-4057qib7 5158 38 ) ) -RRB- cord-005453-4057qib7 5158 39 were be VBD cord-005453-4057qib7 5158 40 predictive predictive JJ cord-005453-4057qib7 5158 41 for for IN cord-005453-4057qib7 5158 42 OS OS NNP cord-005453-4057qib7 5158 43 . . . cord-005453-4057qib7 5159 1 Conclusions conclusion NNS cord-005453-4057qib7 5159 2 : : : cord-005453-4057qib7 5160 1 PTCy PTCy NNP cord-005453-4057qib7 5160 2 - - HYPH cord-005453-4057qib7 5160 3 based base VBN cord-005453-4057qib7 5160 4 GVHD GVHD NNP cord-005453-4057qib7 5160 5 prophylaxis prophylaxis NN cord-005453-4057qib7 5160 6 can can MD cord-005453-4057qib7 5160 7 be be VB cord-005453-4057qib7 5160 8 effective effective JJ cord-005453-4057qib7 5160 9 options option NNS cord-005453-4057qib7 5160 10 for for IN cord-005453-4057qib7 5160 11 reduce reduce VB cord-005453-4057qib7 5160 12 risk risk NN cord-005453-4057qib7 5160 13 of of IN cord-005453-4057qib7 5160 14 acute acute JJ cord-005453-4057qib7 5160 15 GVHD GVHD NNP cord-005453-4057qib7 5160 16 . . . cord-005453-4057qib7 5161 1 Using use VBG cord-005453-4057qib7 5161 2 unrelated unrelated JJ cord-005453-4057qib7 5161 3 donors donor NNS cord-005453-4057qib7 5161 4 , , , cord-005453-4057qib7 5161 5 bone bone NN cord-005453-4057qib7 5161 6 marrow marrow NN cord-005453-4057qib7 5161 7 as as IN cord-005453-4057qib7 5161 8 transplant transplant NN cord-005453-4057qib7 5161 9 source source NN cord-005453-4057qib7 5161 10 and and CC cord-005453-4057qib7 5161 11 MAC MAC NNP cord-005453-4057qib7 5161 12 can can MD cord-005453-4057qib7 5161 13 reduce reduce VB cord-005453-4057qib7 5161 14 CI CI NNP cord-005453-4057qib7 5161 15 of of IN cord-005453-4057qib7 5161 16 GVHD GVHD NNP cord-005453-4057qib7 5161 17 . . . cord-005453-4057qib7 5162 1 Performing perform VBG cord-005453-4057qib7 5162 2 allo allo NN cord-005453-4057qib7 5162 3 - - HYPH cord-005453-4057qib7 5162 4 HSCR HSCR NNP cord-005453-4057qib7 5162 5 earlier early RBR cord-005453-4057qib7 5162 6 from from IN cord-005453-4057qib7 5162 7 diagnos diagnos NNP cord-005453-4057qib7 5162 8 and and CC cord-005453-4057qib7 5162 9 in in IN cord-005453-4057qib7 5162 10 earlier early JJR cord-005453-4057qib7 5162 11 age age NN cord-005453-4057qib7 5162 12 can can MD cord-005453-4057qib7 5162 13 improve improve VB cord-005453-4057qib7 5162 14 OS OS NNP cord-005453-4057qib7 5162 15 patients patient NNS cord-005453-4057qib7 5162 16 with with IN cord-005453-4057qib7 5162 17 inherited inherit VBN cord-005453-4057qib7 5162 18 disorders disorder NNS cord-005453-4057qib7 5162 19 Background background NN cord-005453-4057qib7 5162 20 : : : cord-005453-4057qib7 5162 21 Diarrhea diarrhea NN cord-005453-4057qib7 5162 22 is be VBZ cord-005453-4057qib7 5162 23 a a DT cord-005453-4057qib7 5162 24 frequent frequent JJ cord-005453-4057qib7 5162 25 complication complication NN cord-005453-4057qib7 5162 26 after after IN cord-005453-4057qib7 5162 27 allo allo NN cord-005453-4057qib7 5162 28 - - HYPH cord-005453-4057qib7 5162 29 SCT SCT NNP cord-005453-4057qib7 5162 30 . . . cord-005453-4057qib7 5163 1 At at IN cord-005453-4057qib7 5163 2 onset onset NN cord-005453-4057qib7 5163 3 it -PRON- PRP cord-005453-4057qib7 5163 4 is be VBZ cord-005453-4057qib7 5163 5 often often RB cord-005453-4057qib7 5163 6 difficult difficult JJ cord-005453-4057qib7 5163 7 to to TO cord-005453-4057qib7 5163 8 differentiate differentiate VB cord-005453-4057qib7 5163 9 GI GI NNP cord-005453-4057qib7 5163 10 GvHD GvHD NNP cord-005453-4057qib7 5163 11 from from IN cord-005453-4057qib7 5163 12 other other JJ cord-005453-4057qib7 5163 13 causes cause NNS cord-005453-4057qib7 5163 14 of of IN cord-005453-4057qib7 5163 15 enterocolitis enterocolitis NN cord-005453-4057qib7 5163 16 . . . cord-005453-4057qib7 5164 1 Recently recently RB cord-005453-4057qib7 5164 2 , , , cord-005453-4057qib7 5164 3 non non JJ cord-005453-4057qib7 5164 4 - - JJ cord-005453-4057qib7 5164 5 invasive invasive JJ cord-005453-4057qib7 5164 6 tests test NNS cord-005453-4057qib7 5164 7 , , , cord-005453-4057qib7 5164 8 such such JJ cord-005453-4057qib7 5164 9 as as IN cord-005453-4057qib7 5164 10 fecal fecal JJ cord-005453-4057qib7 5164 11 calprotectin calprotectin NNP cord-005453-4057qib7 5164 12 ( ( -LRB- cord-005453-4057qib7 5164 13 FC FC NNP cord-005453-4057qib7 5164 14 ) ) -RRB- cord-005453-4057qib7 5164 15 , , , cord-005453-4057qib7 5164 16 have have VBP cord-005453-4057qib7 5164 17 been be VBN cord-005453-4057qib7 5164 18 validated validate VBN cord-005453-4057qib7 5164 19 as as IN cord-005453-4057qib7 5164 20 markers marker NNS cord-005453-4057qib7 5164 21 of of IN cord-005453-4057qib7 5164 22 gut gut NN cord-005453-4057qib7 5164 23 inflammation inflammation NN cord-005453-4057qib7 5164 24 in in IN cord-005453-4057qib7 5164 25 patients patient NNS cord-005453-4057qib7 5164 26 with with IN cord-005453-4057qib7 5164 27 Inflammatory inflammatory JJ cord-005453-4057qib7 5164 28 Bowel Bowel NNP cord-005453-4057qib7 5164 29 Disease Disease NNP cord-005453-4057qib7 5164 30 , , , cord-005453-4057qib7 5164 31 but but CC cord-005453-4057qib7 5164 32 only only RB cord-005453-4057qib7 5164 33 a a DT cord-005453-4057qib7 5164 34 few few JJ cord-005453-4057qib7 5164 35 studies study NNS cord-005453-4057qib7 5164 36 have have VBP cord-005453-4057qib7 5164 37 been be VBN cord-005453-4057qib7 5164 38 published publish VBN cord-005453-4057qib7 5164 39 regarding regard VBG cord-005453-4057qib7 5164 40 its -PRON- PRP$ cord-005453-4057qib7 5164 41 use use NN cord-005453-4057qib7 5164 42 as as IN cord-005453-4057qib7 5164 43 a a DT cord-005453-4057qib7 5164 44 diagnostic diagnostic JJ cord-005453-4057qib7 5164 45 marker marker NN cord-005453-4057qib7 5164 46 in in IN cord-005453-4057qib7 5164 47 GI GI NNP cord-005453-4057qib7 5164 48 GvHD GvHD NNP cord-005453-4057qib7 5164 49 . . . cord-005453-4057qib7 5165 1 Methods method NNS cord-005453-4057qib7 5165 2 : : : cord-005453-4057qib7 5166 1 Our -PRON- PRP$ cord-005453-4057qib7 5166 2 aim aim NN cord-005453-4057qib7 5166 3 in in IN cord-005453-4057qib7 5166 4 this this DT cord-005453-4057qib7 5166 5 study study NN cord-005453-4057qib7 5166 6 was be VBD cord-005453-4057qib7 5166 7 to to TO cord-005453-4057qib7 5166 8 explore explore VB cord-005453-4057qib7 5166 9 the the DT cord-005453-4057qib7 5166 10 levels level NNS cord-005453-4057qib7 5166 11 of of IN cord-005453-4057qib7 5166 12 FC FC NNP cord-005453-4057qib7 5166 13 in in IN cord-005453-4057qib7 5166 14 allo allo NNP cord-005453-4057qib7 5166 15 - - HYPH cord-005453-4057qib7 5166 16 SCT SCT NNP cord-005453-4057qib7 5166 17 recipients recipient NNS cord-005453-4057qib7 5166 18 with with IN cord-005453-4057qib7 5166 19 new new JJ cord-005453-4057qib7 5166 20 - - HYPH cord-005453-4057qib7 5166 21 onset onset NN cord-005453-4057qib7 5166 22 diarrhea diarrhea NN cord-005453-4057qib7 5166 23 . . . cord-005453-4057qib7 5167 1 So so RB cord-005453-4057qib7 5167 2 far far RB cord-005453-4057qib7 5167 3 we -PRON- PRP cord-005453-4057qib7 5167 4 have have VBP cord-005453-4057qib7 5167 5 included include VBN cord-005453-4057qib7 5167 6 43 43 CD cord-005453-4057qib7 5167 7 allo allo NN cord-005453-4057qib7 5167 8 - - HYPH cord-005453-4057qib7 5167 9 SCT SCT NNP cord-005453-4057qib7 5167 10 recipients recipient NNS cord-005453-4057qib7 5167 11 who who WP cord-005453-4057qib7 5167 12 developed develop VBD cord-005453-4057qib7 5167 13 acute acute JJ cord-005453-4057qib7 5167 14 diarrhea diarrhea NN cord-005453-4057qib7 5167 15 ≥ ≥ CD cord-005453-4057qib7 5167 16 stage stage NN cord-005453-4057qib7 5167 17 2 2 CD cord-005453-4057qib7 5167 18 - - SYM cord-005453-4057qib7 5167 19 4 4 CD cord-005453-4057qib7 5167 20 at at IN cord-005453-4057qib7 5167 21 a a DT cord-005453-4057qib7 5167 22 median median NN cord-005453-4057qib7 5167 23 of of IN cord-005453-4057qib7 5167 24 75 75 CD cord-005453-4057qib7 5167 25 days day NNS cord-005453-4057qib7 5167 26 ( ( -LRB- cord-005453-4057qib7 5167 27 range:12 range:12 NNP cord-005453-4057qib7 5167 28 - - HYPH cord-005453-4057qib7 5167 29 328 328 CD cord-005453-4057qib7 5167 30 ) ) -RRB- cord-005453-4057qib7 5167 31 post post NN cord-005453-4057qib7 5167 32 allo allo NN cord-005453-4057qib7 5167 33 - - HYPH cord-005453-4057qib7 5167 34 SCT SCT NNP cord-005453-4057qib7 5167 35 . . . cord-005453-4057qib7 5168 1 Stool stool NN cord-005453-4057qib7 5168 2 samples sample NNS cord-005453-4057qib7 5168 3 were be VBD cord-005453-4057qib7 5168 4 analyzed analyze VBN cord-005453-4057qib7 5168 5 as as RB cord-005453-4057qib7 5168 6 soon soon RB cord-005453-4057qib7 5168 7 as as IN cord-005453-4057qib7 5168 8 possible possible JJ cord-005453-4057qib7 5168 9 after after IN cord-005453-4057qib7 5168 10 the the DT cord-005453-4057qib7 5168 11 onset onset NN cord-005453-4057qib7 5168 12 of of IN cord-005453-4057qib7 5168 13 diarrhea diarrhea NN cord-005453-4057qib7 5168 14 . . . cord-005453-4057qib7 5169 1 FC FC NNP cord-005453-4057qib7 5169 2 levels level NNS cord-005453-4057qib7 5169 3 were be VBD cord-005453-4057qib7 5169 4 determined determine VBN cord-005453-4057qib7 5169 5 in in IN cord-005453-4057qib7 5169 6 addition addition NN cord-005453-4057qib7 5169 7 to to IN cord-005453-4057qib7 5169 8 an an DT cord-005453-4057qib7 5169 9 extensive extensive JJ cord-005453-4057qib7 5169 10 microbiological microbiological JJ cord-005453-4057qib7 5169 11 panel panel NN cord-005453-4057qib7 5169 12 for for IN cord-005453-4057qib7 5169 13 infectious infectious JJ cord-005453-4057qib7 5169 14 enterocolitis enterocolitis NN cord-005453-4057qib7 5169 15 ( ( -LRB- cord-005453-4057qib7 5169 16 including include VBG cord-005453-4057qib7 5169 17 norovirus norovirus NN cord-005453-4057qib7 5169 18 PCR PCR NNP cord-005453-4057qib7 5169 19 and and CC cord-005453-4057qib7 5169 20 C. C. NNP cord-005453-4057qib7 5169 21 difficile difficile NN cord-005453-4057qib7 5169 22 associated associate VBN cord-005453-4057qib7 5169 23 diarrhea diarrhea NN cord-005453-4057qib7 5169 24 ) ) -RRB- cord-005453-4057qib7 5169 25 . . . cord-005453-4057qib7 5170 1 Endoscopies endoscopy NNS cord-005453-4057qib7 5170 2 for for IN cord-005453-4057qib7 5170 3 histologic histologic JJ cord-005453-4057qib7 5170 4 analysis analysis NN cord-005453-4057qib7 5170 5 were be VBD cord-005453-4057qib7 5170 6 performed perform VBN cord-005453-4057qib7 5170 7 according accord VBG cord-005453-4057qib7 5170 8 to to IN cord-005453-4057qib7 5170 9 the the DT cord-005453-4057qib7 5170 10 treating treat VBG cord-005453-4057qib7 5170 11 physicians physician NNS cord-005453-4057qib7 5170 12 ' ' POS cord-005453-4057qib7 5170 13 discretion discretion NN cord-005453-4057qib7 5170 14 ( ( -LRB- cord-005453-4057qib7 5170 15 n=15 n=15 NNP cord-005453-4057qib7 5170 16 ) ) -RRB- cord-005453-4057qib7 5170 17 . . . cord-005453-4057qib7 5171 1 Results result NNS cord-005453-4057qib7 5171 2 : : : cord-005453-4057qib7 5172 1 Patients patient NNS cord-005453-4057qib7 5172 2 characteristics characteristic NNS cord-005453-4057qib7 5172 3 are be VBP cord-005453-4057qib7 5172 4 summarized summarize VBN cord-005453-4057qib7 5172 5 in in IN cord-005453-4057qib7 5172 6 Table Table NNP cord-005453-4057qib7 5172 7 _SP cord-005453-4057qib7 5172 8 1 1 CD cord-005453-4057qib7 5172 9 . . . cord-005453-4057qib7 5173 1 Median median JJ cord-005453-4057qib7 5173 2 follow follow NN cord-005453-4057qib7 5173 3 - - HYPH cord-005453-4057qib7 5173 4 up up NN cord-005453-4057qib7 5173 5 for for IN cord-005453-4057qib7 5173 6 survivors survivor NNS cord-005453-4057qib7 5173 7 was be VBD cord-005453-4057qib7 5173 8 524 524 CD cord-005453-4057qib7 5173 9 days day NNS cord-005453-4057qib7 5173 10 ( ( -LRB- cord-005453-4057qib7 5173 11 range:151 range:151 NNP cord-005453-4057qib7 5173 12 - - HYPH cord-005453-4057qib7 5173 13 1834 1834 CD cord-005453-4057qib7 5173 14 ) ) -RRB- cord-005453-4057qib7 5173 15 . . . cord-005453-4057qib7 5174 1 Twenty twenty CD cord-005453-4057qib7 5174 2 - - HYPH cord-005453-4057qib7 5174 3 eight eight CD cord-005453-4057qib7 5174 4 patients patient NNS cord-005453-4057qib7 5174 5 ( ( -LRB- cord-005453-4057qib7 5174 6 65 65 CD cord-005453-4057qib7 5174 7 % % NN cord-005453-4057qib7 5174 8 ) ) -RRB- cord-005453-4057qib7 5174 9 were be VBD cord-005453-4057qib7 5174 10 diagnosed diagnose VBN cord-005453-4057qib7 5174 11 of of IN cord-005453-4057qib7 5174 12 GI GI NNP cord-005453-4057qib7 5174 13 - - HYPH cord-005453-4057qib7 5174 14 GvHD GvHD NNP cord-005453-4057qib7 5174 15 . . . cord-005453-4057qib7 5175 1 The the DT cord-005453-4057qib7 5175 2 additional additional JJ cord-005453-4057qib7 5175 3 causes cause NNS cord-005453-4057qib7 5175 4 of of IN cord-005453-4057qib7 5175 5 diarrhea diarrhea NN cord-005453-4057qib7 5175 6 were be VBD cord-005453-4057qib7 5175 7 : : : cord-005453-4057qib7 5175 8 drug drug NN cord-005453-4057qib7 5175 9 - - HYPH cord-005453-4057qib7 5175 10 related relate VBN cord-005453-4057qib7 5175 11 enterotoxicity enterotoxicity NN cord-005453-4057qib7 5175 12 ( ( -LRB- cord-005453-4057qib7 5175 13 n=6 n=6 NNP cord-005453-4057qib7 5175 14 ) ) -RRB- cord-005453-4057qib7 5175 15 , , , cord-005453-4057qib7 5175 16 viral viral JJ cord-005453-4057qib7 5175 17 enteritis enteritis NN cord-005453-4057qib7 5175 18 ( ( -LRB- cord-005453-4057qib7 5175 19 n=2 n=2 NNS cord-005453-4057qib7 5175 20 ) ) -RRB- cord-005453-4057qib7 5175 21 , , , cord-005453-4057qib7 5175 22 food food NN cord-005453-4057qib7 5175 23 intolerance intolerance NN cord-005453-4057qib7 5175 24 ( ( -LRB- cord-005453-4057qib7 5175 25 n=2 n=2 NNS cord-005453-4057qib7 5175 26 ) ) -RRB- cord-005453-4057qib7 5175 27 , , , cord-005453-4057qib7 5175 28 C.jejuni C.jejuni NNP cord-005453-4057qib7 5175 29 - - HYPH cord-005453-4057qib7 5175 30 enteritis enteritis NN cord-005453-4057qib7 5175 31 ( ( -LRB- cord-005453-4057qib7 5175 32 n=1 n=1 CD cord-005453-4057qib7 5175 33 ) ) -RRB- cord-005453-4057qib7 5175 34 , , , cord-005453-4057qib7 5175 35 and and CC cord-005453-4057qib7 5175 36 non non JJ cord-005453-4057qib7 5175 37 - - JJ cord-005453-4057qib7 5175 38 specific specific JJ cord-005453-4057qib7 5175 39 causes cause NNS cord-005453-4057qib7 5175 40 ( ( -LRB- cord-005453-4057qib7 5175 41 n=4 n=4 NNS cord-005453-4057qib7 5175 42 ) ) -RRB- cord-005453-4057qib7 5175 43 . . . cord-005453-4057qib7 5176 1 The the DT cord-005453-4057qib7 5176 2 concentration concentration NN cord-005453-4057qib7 5176 3 of of IN cord-005453-4057qib7 5176 4 FC FC NNP cord-005453-4057qib7 5176 5 was be VBD cord-005453-4057qib7 5176 6 higher high JJR cord-005453-4057qib7 5176 7 in in IN cord-005453-4057qib7 5176 8 patients patient NNS cord-005453-4057qib7 5176 9 with with IN cord-005453-4057qib7 5176 10 GI GI NNP cord-005453-4057qib7 5176 11 GvHD GvHD NNP cord-005453-4057qib7 5176 12 vs. vs. IN cord-005453-4057qib7 5176 13 other other JJ cord-005453-4057qib7 5176 14 causes cause NNS cord-005453-4057qib7 5176 15 of of IN cord-005453-4057qib7 5176 16 diarrhea diarrhea NN cord-005453-4057qib7 5176 17 ( ( -LRB- cord-005453-4057qib7 5176 18 544μg 544μg NN cord-005453-4057qib7 5176 19 / / SYM cord-005453-4057qib7 5176 20 g g NN cord-005453-4057qib7 5177 1 + + CC cord-005453-4057qib7 5177 2 /-71 /-71 CD cord-005453-4057qib7 5177 3 vs. vs. NN cord-005453-4057qib7 5177 4 58 58 CD cord-005453-4057qib7 5177 5 μg/ μg/ NN cord-005453-4057qib7 5178 1 g g NNP cord-005453-4057qib7 5179 1 + + CC cord-005453-4057qib7 5179 2 /-33 /-33 NNP cord-005453-4057qib7 5179 3 , , , cord-005453-4057qib7 5179 4 p= p= NNP cord-005453-4057qib7 5179 5 0.03 0.03 CD cord-005453-4057qib7 5179 6 ) ) -RRB- cord-005453-4057qib7 5179 7 . . . cord-005453-4057qib7 5180 1 Patients patient NNS cord-005453-4057qib7 5180 2 who who WP cord-005453-4057qib7 5180 3 did do VBD cord-005453-4057qib7 5180 4 not not RB cord-005453-4057qib7 5180 5 develop develop VB cord-005453-4057qib7 5180 6 severe severe JJ cord-005453-4057qib7 5180 7 enterocolitis enterocolitis NN cord-005453-4057qib7 5180 8 had have VBD cord-005453-4057qib7 5180 9 normal normal JJ cord-005453-4057qib7 5180 10 to to IN cord-005453-4057qib7 5180 11 slightly slightly RB cord-005453-4057qib7 5180 12 raised raise VBN cord-005453-4057qib7 5180 13 calprotectin calprotectin NNS cord-005453-4057qib7 5180 14 at at IN cord-005453-4057qib7 5180 15 the the DT cord-005453-4057qib7 5180 16 onset onset NN cord-005453-4057qib7 5180 17 of of IN cord-005453-4057qib7 5180 18 diarrhea diarrhea NN cord-005453-4057qib7 5180 19 [ [ -LRB- cord-005453-4057qib7 5180 20 < < XX cord-005453-4057qib7 5180 21 100 100 CD cord-005453-4057qib7 5180 22 - - HYPH cord-005453-4057qib7 5180 23 150 150 CD cord-005453-4057qib7 5180 24 in in IN cord-005453-4057qib7 5180 25 16 16 CD cord-005453-4057qib7 5180 26 out out IN cord-005453-4057qib7 5180 27 of of IN cord-005453-4057qib7 5180 28 19 19 CD cord-005453-4057qib7 5180 29 ( ( -LRB- cord-005453-4057qib7 5180 30 89 89 CD cord-005453-4057qib7 5180 31 % % NN cord-005453-4057qib7 5180 32 ) ) -RRB- cord-005453-4057qib7 5180 33 cases case NNS cord-005453-4057qib7 5180 34 ] ] -RRB- cord-005453-4057qib7 5180 35 , , , cord-005453-4057qib7 5180 36 including include VBG cord-005453-4057qib7 5180 37 100 100 CD cord-005453-4057qib7 5180 38 % % NN cord-005453-4057qib7 5180 39 ( ( -LRB- cord-005453-4057qib7 5180 40 6/6 6/6 CD cord-005453-4057qib7 5180 41 ) ) -RRB- cord-005453-4057qib7 5180 42 of of IN cord-005453-4057qib7 5180 43 patients patient NNS cord-005453-4057qib7 5180 44 with with IN cord-005453-4057qib7 5180 45 enterotoxic enterotoxic JJ cord-005453-4057qib7 5180 46 drug drug NN cord-005453-4057qib7 5180 47 - - HYPH cord-005453-4057qib7 5180 48 related relate VBN cord-005453-4057qib7 5180 49 diarrhea diarrhea NN cord-005453-4057qib7 5180 50 . . . cord-005453-4057qib7 5181 1 Among among IN cord-005453-4057qib7 5181 2 the the DT cord-005453-4057qib7 5181 3 28 28 CD cord-005453-4057qib7 5181 4 patients patient NNS cord-005453-4057qib7 5181 5 with with IN cord-005453-4057qib7 5181 6 GI GI NNP cord-005453-4057qib7 5181 7 - - HYPH cord-005453-4057qib7 5181 8 GvHD GvHD NNP cord-005453-4057qib7 5181 9 , , , cord-005453-4057qib7 5181 10 13 13 CD cord-005453-4057qib7 5181 11 ( ( -LRB- cord-005453-4057qib7 5181 12 30.2 30.2 CD cord-005453-4057qib7 5181 13 % % NN cord-005453-4057qib7 5181 14 ) ) -RRB- cord-005453-4057qib7 5181 15 were be VBD cord-005453-4057qib7 5181 16 later later RB cord-005453-4057qib7 5181 17 found find VBN cord-005453-4057qib7 5181 18 to to TO cord-005453-4057qib7 5181 19 be be VB cord-005453-4057qib7 5181 20 steroid steroid NN cord-005453-4057qib7 5181 21 - - HYPH cord-005453-4057qib7 5181 22 resistant resistant JJ cord-005453-4057qib7 5181 23 . . . cord-005453-4057qib7 5182 1 As as IN cord-005453-4057qib7 5182 2 shown show VBN cord-005453-4057qib7 5182 3 in in IN cord-005453-4057qib7 5182 4 Figure figure NN cord-005453-4057qib7 5182 5 1 1 CD cord-005453-4057qib7 5182 6 , , , cord-005453-4057qib7 5182 7 we -PRON- PRP cord-005453-4057qib7 5182 8 found find VBD cord-005453-4057qib7 5182 9 a a DT cord-005453-4057qib7 5182 10 significant significant JJ cord-005453-4057qib7 5182 11 association association NN cord-005453-4057qib7 5182 12 between between IN cord-005453-4057qib7 5182 13 high high JJ cord-005453-4057qib7 5182 14 FC FC NNP cord-005453-4057qib7 5182 15 ( ( -LRB- cord-005453-4057qib7 5182 16 ≥400μg ≥400μg NNP cord-005453-4057qib7 5182 17 / / SYM cord-005453-4057qib7 5182 18 g g NN cord-005453-4057qib7 5182 19 ) ) -RRB- cord-005453-4057qib7 5182 20 and and CC cord-005453-4057qib7 5182 21 severe severe JJ cord-005453-4057qib7 5182 22 - - HYPH cord-005453-4057qib7 5182 23 refractory refractory JJ cord-005453-4057qib7 5182 24 GvHD gvhd NN cord-005453-4057qib7 5182 25 ( ( -LRB- cord-005453-4057qib7 5182 26 HR HR NNP cord-005453-4057qib7 5182 27 5.7 5.7 CD cord-005453-4057qib7 5182 28 , , , cord-005453-4057qib7 5182 29 p=0.01 p=0.01 NNP cord-005453-4057qib7 5182 30 ) ) -RRB- cord-005453-4057qib7 5182 31 . . . cord-005453-4057qib7 5183 1 Of of IN cord-005453-4057qib7 5183 2 note note VB cord-005453-4057qib7 5183 3 , , , cord-005453-4057qib7 5183 4 high high JJ cord-005453-4057qib7 5183 5 values value NNS cord-005453-4057qib7 5183 6 of of IN cord-005453-4057qib7 5183 7 FC FC NNP cord-005453-4057qib7 5183 8 were be VBD cord-005453-4057qib7 5183 9 also also RB cord-005453-4057qib7 5183 10 found find VBN cord-005453-4057qib7 5183 11 in in IN cord-005453-4057qib7 5183 12 3 3 CD cord-005453-4057qib7 5183 13 patients patient NNS cord-005453-4057qib7 5183 14 with with IN cord-005453-4057qib7 5183 15 severe severe JJ cord-005453-4057qib7 5183 16 infectious infectious JJ cord-005453-4057qib7 5183 17 enteritis enteritis NN cord-005453-4057qib7 5183 18 ( ( -LRB- cord-005453-4057qib7 5183 19 norovirus norovirus NN cord-005453-4057qib7 5183 20 , , , cord-005453-4057qib7 5183 21 adenovirus adenovirus NN cord-005453-4057qib7 5183 22 and and CC cord-005453-4057qib7 5183 23 C.jejuni C.jejuni NNP cord-005453-4057qib7 5183 24 infections infection NNS cord-005453-4057qib7 5183 25 ) ) -RRB- cord-005453-4057qib7 5183 26 , , , cord-005453-4057qib7 5183 27 with with IN cord-005453-4057qib7 5183 28 baseline baseline JJ cord-005453-4057qib7 5183 29 FC>800 FC>800 NNP cord-005453-4057qib7 5183 30 μg μg NNP cord-005453-4057qib7 5183 31 / / SYM cord-005453-4057qib7 5183 32 g g NN cord-005453-4057qib7 5183 33 , , , cord-005453-4057qib7 5183 34 respectively respectively RB cord-005453-4057qib7 5183 35 . . . cord-005453-4057qib7 5184 1 Overall overall JJ cord-005453-4057qib7 5184 2 survival survival NN cord-005453-4057qib7 5184 3 was be VBD cord-005453-4057qib7 5184 4 78 78 CD cord-005453-4057qib7 5184 5 % % NN cord-005453-4057qib7 5185 1 ( ( -LRB- cord-005453-4057qib7 5185 2 IC95%:65 ic95%:65 NN cord-005453-4057qib7 5185 3 - - HYPH cord-005453-4057qib7 5185 4 91 91 CD cord-005453-4057qib7 5185 5 ) ) -RRB- cord-005453-4057qib7 5186 1 at at IN cord-005453-4057qib7 5186 2 12 12 CD cord-005453-4057qib7 5186 3 months month NNS cord-005453-4057qib7 5186 4 . . . cord-005453-4057qib7 5187 1 Hypoalbuminemia Hypoalbuminemia NNP cord-005453-4057qib7 5187 2 and and CC cord-005453-4057qib7 5187 3 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 5187 4 were be VBD cord-005453-4057qib7 5187 5 the the DT cord-005453-4057qib7 5187 6 only only JJ cord-005453-4057qib7 5187 7 variables variable NNS cord-005453-4057qib7 5187 8 linked link VBN cord-005453-4057qib7 5187 9 to to IN cord-005453-4057qib7 5187 10 1-yr 1-yr CD cord-005453-4057qib7 5187 11 OS os NN cord-005453-4057qib7 5187 12 in in IN cord-005453-4057qib7 5187 13 univariate univariate JJ cord-005453-4057qib7 5187 14 analysis analysis NN cord-005453-4057qib7 5187 15 , , , cord-005453-4057qib7 5187 16 regardless regardless RB cord-005453-4057qib7 5187 17 of of IN cord-005453-4057qib7 5187 18 the the DT cord-005453-4057qib7 5187 19 cause cause NN cord-005453-4057qib7 5187 20 of of IN cord-005453-4057qib7 5187 21 enterocolitis enterocolitis NN cord-005453-4057qib7 5187 22 . . . cord-005453-4057qib7 5188 1 Conclusions conclusion NNS cord-005453-4057qib7 5188 2 : : : cord-005453-4057qib7 5189 1 In in IN cord-005453-4057qib7 5189 2 the the DT cord-005453-4057qib7 5189 3 absence absence NN cord-005453-4057qib7 5189 4 of of IN cord-005453-4057qib7 5189 5 standarized standarized JJ cord-005453-4057qib7 5189 6 ( ( -LRB- cord-005453-4057qib7 5189 7 and and CC cord-005453-4057qib7 5189 8 expensive expensive JJ cord-005453-4057qib7 5189 9 ) ) -RRB- cord-005453-4057qib7 5189 10 biomarker biomarker NN cord-005453-4057qib7 5189 11 panels panel NNS cord-005453-4057qib7 5189 12 for for IN cord-005453-4057qib7 5189 13 analyzing analyze VBG cord-005453-4057qib7 5189 14 and and CC cord-005453-4057qib7 5189 15 predicting predict VBG cord-005453-4057qib7 5189 16 GVHD GVHD NNP cord-005453-4057qib7 5189 17 onset onset NN cord-005453-4057qib7 5189 18 and and CC cord-005453-4057qib7 5189 19 outcomes outcome NNS cord-005453-4057qib7 5189 20 , , , cord-005453-4057qib7 5189 21 the the DT cord-005453-4057qib7 5189 22 FC FC NNP cord-005453-4057qib7 5189 23 test test NN cord-005453-4057qib7 5189 24 may may MD cord-005453-4057qib7 5189 25 be be VB cord-005453-4057qib7 5189 26 an an DT cord-005453-4057qib7 5189 27 useful useful JJ cord-005453-4057qib7 5189 28 tool tool NN cord-005453-4057qib7 5189 29 in in IN cord-005453-4057qib7 5189 30 the the DT cord-005453-4057qib7 5189 31 allo allo NNP cord-005453-4057qib7 5189 32 - - HYPH cord-005453-4057qib7 5189 33 SCT sct NN cord-005453-4057qib7 5189 34 setting setting NN cord-005453-4057qib7 5189 35 . . . cord-005453-4057qib7 5190 1 Our -PRON- PRP$ cord-005453-4057qib7 5190 2 initial initial JJ cord-005453-4057qib7 5190 3 results result NNS cord-005453-4057qib7 5190 4 show show VBP cord-005453-4057qib7 5190 5 that that IN cord-005453-4057qib7 5190 6 FC FC NNP cord-005453-4057qib7 5190 7 is be VBZ cord-005453-4057qib7 5190 8 helpful helpful JJ cord-005453-4057qib7 5190 9 in in IN cord-005453-4057qib7 5190 10 predicting predict VBG cord-005453-4057qib7 5190 11 mild mild JJ cord-005453-4057qib7 5190 12 causes cause NNS cord-005453-4057qib7 5190 13 of of IN cord-005453-4057qib7 5190 14 diarrhea diarrhea NN cord-005453-4057qib7 5190 15 and and CC cord-005453-4057qib7 5190 16 to to TO cord-005453-4057qib7 5190 17 identify identify VB cord-005453-4057qib7 5190 18 patients patient NNS cord-005453-4057qib7 5190 19 with with IN cord-005453-4057qib7 5190 20 a a DT cord-005453-4057qib7 5190 21 high high JJ cord-005453-4057qib7 5190 22 probability probability NN cord-005453-4057qib7 5190 23 of of IN cord-005453-4057qib7 5190 24 developing develop VBG cord-005453-4057qib7 5190 25 severe severe JJ cord-005453-4057qib7 5190 26 ( ( -LRB- cord-005453-4057qib7 5190 27 and and CC cord-005453-4057qib7 5190 28 potentially potentially RB cord-005453-4057qib7 5190 29 steroid steroid JJ cord-005453-4057qib7 5190 30 - - HYPH cord-005453-4057qib7 5190 31 refractory refractory JJ cord-005453-4057qib7 5190 32 ) ) -RRB- cord-005453-4057qib7 5190 33 GI GI NNP cord-005453-4057qib7 5190 34 GvHD GvHD NNP cord-005453-4057qib7 5190 35 , , , cord-005453-4057qib7 5190 36 although although IN cord-005453-4057qib7 5190 37 high high JJ cord-005453-4057qib7 5190 38 levels level NNS cord-005453-4057qib7 5190 39 are be VBP cord-005453-4057qib7 5190 40 also also RB cord-005453-4057qib7 5190 41 found find VBN cord-005453-4057qib7 5190 42 in in IN cord-005453-4057qib7 5190 43 severe severe JJ cord-005453-4057qib7 5190 44 infectious infectious JJ cord-005453-4057qib7 5190 45 enteritis enteritis NN cord-005453-4057qib7 5190 46 . . . cord-005453-4057qib7 5191 1 Background background NN cord-005453-4057qib7 5191 2 : : : cord-005453-4057qib7 5192 1 There there EX cord-005453-4057qib7 5192 2 is be VBZ cord-005453-4057qib7 5192 3 an an DT cord-005453-4057qib7 5192 4 urgent urgent JJ cord-005453-4057qib7 5192 5 need need NN cord-005453-4057qib7 5192 6 for for IN cord-005453-4057qib7 5192 7 effective effective JJ cord-005453-4057qib7 5192 8 therapy therapy NN cord-005453-4057qib7 5192 9 for for IN cord-005453-4057qib7 5192 10 severe severe JJ cord-005453-4057qib7 5192 11 acute acute JJ cord-005453-4057qib7 5192 12 GVHD GVHD NNP cord-005453-4057qib7 5192 13 . . . cord-005453-4057qib7 5193 1 Results result NNS cord-005453-4057qib7 5193 2 of of IN cord-005453-4057qib7 5193 3 GVHD GVHD NNP cord-005453-4057qib7 5193 4 therapies therapy NNS cord-005453-4057qib7 5193 5 beyond beyond IN cord-005453-4057qib7 5193 6 6 6 CD cord-005453-4057qib7 5193 7 months month NNS cord-005453-4057qib7 5193 8 are be VBP cord-005453-4057qib7 5193 9 rarely rarely RB cord-005453-4057qib7 5193 10 reported report VBN cord-005453-4057qib7 5193 11 . . . cord-005453-4057qib7 5194 1 We -PRON- PRP cord-005453-4057qib7 5194 2 here here RB cord-005453-4057qib7 5194 3 report report VBP cord-005453-4057qib7 5194 4 a a DT cord-005453-4057qib7 5194 5 median median JJ cord-005453-4057qib7 5194 6 follow follow NN cord-005453-4057qib7 5194 7 - - HYPH cord-005453-4057qib7 5194 8 up up NN cord-005453-4057qib7 5194 9 of of IN cord-005453-4057qib7 5194 10 4 4 CD cord-005453-4057qib7 5194 11 years year NNS cord-005453-4057qib7 5194 12 . . . cord-005453-4057qib7 5195 1 We -PRON- PRP cord-005453-4057qib7 5195 2 introduced introduce VBD cord-005453-4057qib7 5195 3 mesenchymal mesenchymal JJ cord-005453-4057qib7 5195 4 stromal stromal JJ cord-005453-4057qib7 5195 5 cells cell NNS cord-005453-4057qib7 5195 6 as as IN cord-005453-4057qib7 5195 7 therapy therapy NN cord-005453-4057qib7 5195 8 for for IN cord-005453-4057qib7 5195 9 severe severe JJ cord-005453-4057qib7 5195 10 acute acute JJ cord-005453-4057qib7 5195 11 GVHD GVHD NNP cord-005453-4057qib7 5195 12 , , , cord-005453-4057qib7 5195 13 with with IN cord-005453-4057qib7 5195 14 a a DT cord-005453-4057qib7 5195 15 dramatic dramatic JJ cord-005453-4057qib7 5195 16 response response NN cord-005453-4057qib7 5195 17 in in IN cord-005453-4057qib7 5195 18 some some DT cord-005453-4057qib7 5195 19 , , , cord-005453-4057qib7 5195 20 but but CC cord-005453-4057qib7 5195 21 not not RB cord-005453-4057qib7 5195 22 all all DT cord-005453-4057qib7 5195 23 patients patient NNS cord-005453-4057qib7 5195 24 . . . cord-005453-4057qib7 5196 1 The the DT cord-005453-4057qib7 5196 2 placenta placenta NN cord-005453-4057qib7 5196 3 protects protect VBZ cord-005453-4057qib7 5196 4 the the DT cord-005453-4057qib7 5196 5 fetus fetus NN cord-005453-4057qib7 5196 6 from from IN cord-005453-4057qib7 5196 7 the the DT cord-005453-4057qib7 5196 8 mothers mother NNS cord-005453-4057qib7 5196 9 haploidentical haploidentical JJ cord-005453-4057qib7 5196 10 immune immune JJ cord-005453-4057qib7 5196 11 system system NN cord-005453-4057qib7 5196 12 during during IN cord-005453-4057qib7 5196 13 pregnancy pregnancy NN cord-005453-4057qib7 5196 14 . . . cord-005453-4057qib7 5197 1 We -PRON- PRP cord-005453-4057qib7 5197 2 found find VBD cord-005453-4057qib7 5197 3 that that IN cord-005453-4057qib7 5197 4 maternal maternal JJ cord-005453-4057qib7 5197 5 stromal stromal NN cord-005453-4057qib7 5197 6 cells cell NNS cord-005453-4057qib7 5197 7 from from IN cord-005453-4057qib7 5197 8 the the DT cord-005453-4057qib7 5197 9 fetal fetal JJ cord-005453-4057qib7 5197 10 membrane membrane NN cord-005453-4057qib7 5197 11 , , , cord-005453-4057qib7 5197 12 so so CC cord-005453-4057qib7 5197 13 called call VBN cord-005453-4057qib7 5197 14 decidua decidua NN cord-005453-4057qib7 5197 15 stromal stromal NN cord-005453-4057qib7 5197 16 cells cell NNS cord-005453-4057qib7 5197 17 ( ( -LRB- cord-005453-4057qib7 5197 18 DSCs dsc NNS cord-005453-4057qib7 5197 19 ) ) -RRB- cord-005453-4057qib7 5197 20 were be VBD cord-005453-4057qib7 5197 21 more more RBR cord-005453-4057qib7 5197 22 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 5197 23 than than IN cord-005453-4057qib7 5197 24 other other JJ cord-005453-4057qib7 5197 25 sources source NNS cord-005453-4057qib7 5197 26 of of IN cord-005453-4057qib7 5197 27 stromal stromal JJ cord-005453-4057qib7 5197 28 cells cell NNS cord-005453-4057qib7 5197 29 . . . cord-005453-4057qib7 5198 1 Methods method NNS cord-005453-4057qib7 5198 2 : : : cord-005453-4057qib7 5198 3 We -PRON- PRP cord-005453-4057qib7 5198 4 treated treat VBD cord-005453-4057qib7 5198 5 21 21 CD cord-005453-4057qib7 5198 6 patients patient NNS cord-005453-4057qib7 5198 7 , , , cord-005453-4057qib7 5198 8 median median NN cord-005453-4057qib7 5198 9 49 49 CD cord-005453-4057qib7 5198 10 years year NNS cord-005453-4057qib7 5198 11 of of IN cord-005453-4057qib7 5198 12 age age NN cord-005453-4057qib7 5198 13 ( ( -LRB- cord-005453-4057qib7 5198 14 range range VBP cord-005453-4057qib7 5198 15 1.6 1.6 CD cord-005453-4057qib7 5198 16 - - SYM cord-005453-4057qib7 5198 17 72 72 CD cord-005453-4057qib7 5198 18 ) ) -RRB- cord-005453-4057qib7 5198 19 for for IN cord-005453-4057qib7 5198 20 severe severe JJ cord-005453-4057qib7 5198 21 acute acute JJ cord-005453-4057qib7 5198 22 GVHD GVHD NNP cord-005453-4057qib7 5198 23 . . . cord-005453-4057qib7 5199 1 All all DT cord-005453-4057qib7 5199 2 had have VBD cord-005453-4057qib7 5199 3 biopsy biopsy NN cord-005453-4057qib7 5199 4 proven prove VBN cord-005453-4057qib7 5199 5 gastro gastro JJ cord-005453-4057qib7 5199 6 - - JJ cord-005453-4057qib7 5199 7 intestinal intestinal JJ cord-005453-4057qib7 5199 8 GVHD GVHD NNP cord-005453-4057qib7 5199 9 . . . cord-005453-4057qib7 5200 1 All all DT cord-005453-4057qib7 5200 2 were be VBD cord-005453-4057qib7 5200 3 steroid steroid NN cord-005453-4057qib7 5200 4 refractory,11 refractory,11 NN cord-005453-4057qib7 5200 5 after after IN cord-005453-4057qib7 5200 6 > > XX cord-005453-4057qib7 5200 7 7days 7days CD cord-005453-4057qib7 5200 8 or or CC cord-005453-4057qib7 5200 9 with with IN cord-005453-4057qib7 5200 10 progression progression NN cord-005453-4057qib7 5200 11 and and CC cord-005453-4057qib7 5200 12 10 10 CD cord-005453-4057qib7 5200 13 after after IN cord-005453-4057qib7 5200 14 > > XX cord-005453-4057qib7 5200 15 3 3 CD cord-005453-4057qib7 5200 16 days day NNS cord-005453-4057qib7 5200 17 . . . cord-005453-4057qib7 5201 1 We -PRON- PRP cord-005453-4057qib7 5201 2 used use VBD cord-005453-4057qib7 5201 3 an an DT cord-005453-4057qib7 5201 4 improved improved JJ cord-005453-4057qib7 5201 5 protocol protocol NN cord-005453-4057qib7 5201 6 where where WRB cord-005453-4057qib7 5201 7 DSCs dsc NNS cord-005453-4057qib7 5201 8 were be VBD cord-005453-4057qib7 5201 9 thawed thaw VBN cord-005453-4057qib7 5201 10 and and CC cord-005453-4057qib7 5201 11 infused infuse VBN cord-005453-4057qib7 5201 12 in in IN cord-005453-4057qib7 5201 13 a a DT cord-005453-4057qib7 5201 14 buffer buffer NN cord-005453-4057qib7 5201 15 with with IN cord-005453-4057qib7 5201 16 5 5 CD cord-005453-4057qib7 5201 17 % % NN cord-005453-4057qib7 5201 18 albumin albumin NN cord-005453-4057qib7 5201 19 . . . cord-005453-4057qib7 5202 1 DSCs DSCs NNP cord-005453-4057qib7 5202 2 were be VBD cord-005453-4057qib7 5202 3 given give VBN cord-005453-4057qib7 5202 4 at at IN cord-005453-4057qib7 5202 5 a a DT cord-005453-4057qib7 5202 6 median median JJ cord-005453-4057qib7 5202 7 dose dose NN cord-005453-4057qib7 5202 8 of of IN cord-005453-4057qib7 5202 9 1.2 1.2 CD cord-005453-4057qib7 5202 10 ( ( -LRB- cord-005453-4057qib7 5202 11 0.9 0.9 CD cord-005453-4057qib7 5202 12 - - SYM cord-005453-4057qib7 5202 13 2.9 2.9 CD cord-005453-4057qib7 5202 14 ) ) -RRB- cord-005453-4057qib7 5202 15 x x SYM cord-005453-4057qib7 5202 16 10 10 CD cord-005453-4057qib7 5202 17 6 6 CD cord-005453-4057qib7 5202 18 cells cell NNS cord-005453-4057qib7 5202 19 / / SYM cord-005453-4057qib7 5202 20 kg kg NNS cord-005453-4057qib7 5202 21 and and CC cord-005453-4057qib7 5202 22 2(1 2(1 NNP cord-005453-4057qib7 5202 23 - - HYPH cord-005453-4057qib7 5202 24 6 6 CD cord-005453-4057qib7 5202 25 ) ) -RRB- cord-005453-4057qib7 5202 26 doses dose NNS cord-005453-4057qib7 5202 27 , , , cord-005453-4057qib7 5202 28 given give VBN cord-005453-4057qib7 5202 29 one one CD cord-005453-4057qib7 5202 30 week week NN cord-005453-4057qib7 5202 31 apart apart RB cord-005453-4057qib7 5202 32 . . . cord-005453-4057qib7 5203 1 Viability viability NN cord-005453-4057qib7 5203 2 of of IN cord-005453-4057qib7 5203 3 frozen frozen JJ cord-005453-4057qib7 5203 4 and and CC cord-005453-4057qib7 5203 5 thawed thaw VBN cord-005453-4057qib7 5203 6 DSCs dsc NNS cord-005453-4057qib7 5203 7 was be VBD cord-005453-4057qib7 5203 8 95 95 CD cord-005453-4057qib7 5203 9 % % NN cord-005453-4057qib7 5203 10 ( ( -LRB- cord-005453-4057qib7 5203 11 89 89 CD cord-005453-4057qib7 5203 12 - - SYM cord-005453-4057qib7 5203 13 100 100 CD cord-005453-4057qib7 5203 14 ) ) -RRB- cord-005453-4057qib7 5203 15 and and CC cord-005453-4057qib7 5203 16 cell cell NN cord-005453-4057qib7 5203 17 passage passage NN cord-005453-4057qib7 5203 18 was be VBD cord-005453-4057qib7 5203 19 4 4 CD cord-005453-4057qib7 5203 20 ( ( -LRB- cord-005453-4057qib7 5203 21 2 2 CD cord-005453-4057qib7 5203 22 - - SYM cord-005453-4057qib7 5203 23 4 4 CD cord-005453-4057qib7 5203 24 ) ) -RRB- cord-005453-4057qib7 5203 25 . . . cord-005453-4057qib7 5204 1 Results result NNS cord-005453-4057qib7 5204 2 : : : cord-005453-4057qib7 5205 1 Complete complete JJ cord-005453-4057qib7 5205 2 resolution resolution NN cord-005453-4057qib7 5205 3 of of IN cord-005453-4057qib7 5205 4 GVHD GVHD NNP cord-005453-4057qib7 5205 5 was be VBD cord-005453-4057qib7 5205 6 seen see VBN cord-005453-4057qib7 5205 7 in in IN cord-005453-4057qib7 5205 8 11 11 CD cord-005453-4057qib7 5205 9 patients patient NNS cord-005453-4057qib7 5205 10 and and CC cord-005453-4057qib7 5205 11 10 10 CD cord-005453-4057qib7 5205 12 had have VBD cord-005453-4057qib7 5205 13 a a DT cord-005453-4057qib7 5205 14 partial partial JJ cord-005453-4057qib7 5205 15 response response NN cord-005453-4057qib7 5205 16 . . . cord-005453-4057qib7 5206 1 The the DT cord-005453-4057qib7 5206 2 cumulative cumulative JJ cord-005453-4057qib7 5206 3 incidence incidence NN cord-005453-4057qib7 5206 4 of of IN cord-005453-4057qib7 5206 5 chronic chronic JJ cord-005453-4057qib7 5206 6 GVHD GVHD NNP cord-005453-4057qib7 5206 7 was be VBD cord-005453-4057qib7 5206 8 52 52 CD cord-005453-4057qib7 5206 9 % % NN cord-005453-4057qib7 5206 10 . . . cord-005453-4057qib7 5207 1 Six six CD cord-005453-4057qib7 5207 2 had have VBD cord-005453-4057qib7 5207 3 mild mild JJ cord-005453-4057qib7 5207 4 , , , cord-005453-4057qib7 5207 5 4 4 CD cord-005453-4057qib7 5207 6 moderate moderate JJ cord-005453-4057qib7 5207 7 and and CC cord-005453-4057qib7 5207 8 one one CD cord-005453-4057qib7 5207 9 severe severe JJ cord-005453-4057qib7 5207 10 NIH NIH NNP cord-005453-4057qib7 5207 11 overall overall JJ cord-005453-4057qib7 5207 12 GVHD GVHD NNP cord-005453-4057qib7 5207 13 severity severity NN cord-005453-4057qib7 5207 14 scoring scoring NN cord-005453-4057qib7 5207 15 . . . cord-005453-4057qib7 5208 1 Nine nine CD cord-005453-4057qib7 5208 2 patients patient NNS cord-005453-4057qib7 5208 3 died die VBD cord-005453-4057qib7 5208 4 , , , cord-005453-4057qib7 5208 5 3 3 CD cord-005453-4057qib7 5208 6 from from IN cord-005453-4057qib7 5208 7 relapse relapse NN cord-005453-4057qib7 5208 8 , , , cord-005453-4057qib7 5208 9 1 1 CD cord-005453-4057qib7 5208 10 acute acute JJ cord-005453-4057qib7 5208 11 GVHD GVHD NNP cord-005453-4057qib7 5208 12 and and CC cord-005453-4057qib7 5208 13 septicemia septicemia NN cord-005453-4057qib7 5208 14 , , , cord-005453-4057qib7 5208 15 1 1 CD cord-005453-4057qib7 5208 16 zygomycetes zygomycetes NN cord-005453-4057qib7 5208 17 infection infection NN cord-005453-4057qib7 5208 18 , , , cord-005453-4057qib7 5208 19 1 1 CD cord-005453-4057qib7 5208 20 liver liver NN cord-005453-4057qib7 5208 21 insufficiency insufficiency NN cord-005453-4057qib7 5208 22 , , , cord-005453-4057qib7 5208 23 1 1 CD cord-005453-4057qib7 5208 24 cerebral cerebral JJ cord-005453-4057qib7 5208 25 hemorrhage hemorrhage NN cord-005453-4057qib7 5208 26 , , , cord-005453-4057qib7 5208 27 1multiorgan 1multiorgan CD cord-005453-4057qib7 5208 28 failure failure NN cord-005453-4057qib7 5208 29 and and CC cord-005453-4057qib7 5208 30 1 1 CD cord-005453-4057qib7 5208 31 chronic chronic JJ cord-005453-4057qib7 5208 32 GVHD GVHD NNP cord-005453-4057qib7 5208 33 with with IN cord-005453-4057qib7 5208 34 obstructive obstructive JJ cord-005453-4057qib7 5208 35 bronchiolitis bronchiolitis NN cord-005453-4057qib7 5208 36 . . . cord-005453-4057qib7 5209 1 Four four CD cord-005453-4057qib7 5209 2 years year NNS cord-005453-4057qib7 5209 3 transplant transplant NN cord-005453-4057qib7 5209 4 related relate VBN cord-005453-4057qib7 5209 5 mortalliy mortalliy NNP cord-005453-4057qib7 5209 6 was be VBD cord-005453-4057qib7 5209 7 28.6 28.6 CD cord-005453-4057qib7 5209 8 % % NN cord-005453-4057qib7 5209 9 and and CC cord-005453-4057qib7 5209 10 overall overall JJ cord-005453-4057qib7 5209 11 survival survival NN cord-005453-4057qib7 5209 12 was be VBD cord-005453-4057qib7 5209 13 57 57 CD cord-005453-4057qib7 5209 14 % % NN cord-005453-4057qib7 5209 15 . . . cord-005453-4057qib7 5210 1 Survival survival NN cord-005453-4057qib7 5210 2 was be VBD cord-005453-4057qib7 5210 3 not not RB cord-005453-4057qib7 5210 4 significantly significantly RB cord-005453-4057qib7 5210 5 worse bad JJR cord-005453-4057qib7 5211 1 ( ( -LRB- cord-005453-4057qib7 5211 2 p=0.33 p=0.33 NNP cord-005453-4057qib7 5211 3 ) ) -RRB- cord-005453-4057qib7 5211 4 than than IN cord-005453-4057qib7 5211 5 66 66 CD cord-005453-4057qib7 5211 6 % % NN cord-005453-4057qib7 5211 7 for for IN cord-005453-4057qib7 5211 8 all all DT cord-005453-4057qib7 5211 9 293 293 CD cord-005453-4057qib7 5211 10 patients patient NNS cord-005453-4057qib7 5211 11 undergoing undergo VBG cord-005453-4057qib7 5211 12 allogeneic allogeneic IN cord-005453-4057qib7 5211 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 5211 14 cell cell NN cord-005453-4057qib7 5211 15 transplantation transplantation NN cord-005453-4057qib7 5211 16 during during IN cord-005453-4057qib7 5211 17 the the DT cord-005453-4057qib7 5211 18 same same JJ cord-005453-4057qib7 5211 19 period period NN cord-005453-4057qib7 5211 20 2012 2012 CD cord-005453-4057qib7 5211 21 - - SYM cord-005453-4057qib7 5211 22 2015 2015 CD cord-005453-4057qib7 5211 23 . . . cord-005453-4057qib7 5212 1 Conclusions conclusion NNS cord-005453-4057qib7 5212 2 : : : cord-005453-4057qib7 5213 1 To to TO cord-005453-4057qib7 5213 2 conclude conclude VB cord-005453-4057qib7 5213 3 , , , cord-005453-4057qib7 5213 4 DSCs DSCs NNP cord-005453-4057qib7 5213 5 seems seem VBZ cord-005453-4057qib7 5213 6 to to TO cord-005453-4057qib7 5213 7 be be VB cord-005453-4057qib7 5213 8 a a DT cord-005453-4057qib7 5213 9 promising promising JJ cord-005453-4057qib7 5213 10 therapy therapy NN cord-005453-4057qib7 5213 11 for for IN cord-005453-4057qib7 5213 12 severe severe JJ cord-005453-4057qib7 5213 13 acute acute JJ cord-005453-4057qib7 5213 14 GVHD GVHD NNP cord-005453-4057qib7 5213 15 . . . cord-005453-4057qib7 5214 1 Randomized randomized JJ cord-005453-4057qib7 5214 2 trials trial NNS cord-005453-4057qib7 5214 3 are be VBP cord-005453-4057qib7 5214 4 under under IN cord-005453-4057qib7 5214 5 way way NN cord-005453-4057qib7 5214 6 . . . cord-005453-4057qib7 5215 1 Disclosure disclosure NN cord-005453-4057qib7 5215 2 : : : cord-005453-4057qib7 5215 3 Nothing nothing NN cord-005453-4057qib7 5215 4 to to TO cord-005453-4057qib7 5215 5 declare declare VB cord-005453-4057qib7 5215 6 P237 P237 NNP cord-005453-4057qib7 5215 7 Anti anti JJ cord-005453-4057qib7 5215 8 - - JJ cord-005453-4057qib7 5215 9 apoptotic apoptotic JJ cord-005453-4057qib7 5215 10 protein protein NN cord-005453-4057qib7 5215 11 BCL-2 BCL-2 NNP cord-005453-4057qib7 5215 12 is be VBZ cord-005453-4057qib7 5215 13 upregulated upregulate VBN cord-005453-4057qib7 5215 14 in in IN cord-005453-4057qib7 5215 15 graftversus graftversus NNP cord-005453-4057qib7 5215 16 - - HYPH cord-005453-4057qib7 5215 17 host host NN cord-005453-4057qib7 5215 18 disease disease NN cord-005453-4057qib7 5215 19 stem stem NN cord-005453-4057qib7 5215 20 cell cell NN cord-005453-4057qib7 5215 21 transplantation transplantation NN cord-005453-4057qib7 5215 22 ( ( -LRB- cord-005453-4057qib7 5215 23 allo allo NN cord-005453-4057qib7 5215 24 - - HYPH cord-005453-4057qib7 5215 25 HSCT HSCT NNP cord-005453-4057qib7 5215 26 ) ) -RRB- cord-005453-4057qib7 5215 27 with with IN cord-005453-4057qib7 5215 28 30 30 CD cord-005453-4057qib7 5215 29 - - SYM cord-005453-4057qib7 5215 30 80 80 CD cord-005453-4057qib7 5215 31 % % NN cord-005453-4057qib7 5215 32 developing develop VBG cord-005453-4057qib7 5215 33 either either CC cord-005453-4057qib7 5215 34 acute acute JJ cord-005453-4057qib7 5215 35 or or CC cord-005453-4057qib7 5215 36 chronic chronic JJ cord-005453-4057qib7 5215 37 GVHD GVHD NNP cord-005453-4057qib7 5215 38 . . . cord-005453-4057qib7 5216 1 Recently recently RB cord-005453-4057qib7 5216 2 , , , cord-005453-4057qib7 5216 3 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5216 4 inhibitor inhibitor NN cord-005453-4057qib7 5216 5 Venetoclax Venetoclax NNP cord-005453-4057qib7 5216 6 was be VBD cord-005453-4057qib7 5216 7 approved approve VBN cord-005453-4057qib7 5216 8 for for IN cord-005453-4057qib7 5216 9 treatment treatment NN cord-005453-4057qib7 5216 10 of of IN cord-005453-4057qib7 5216 11 chronic chronic JJ cord-005453-4057qib7 5216 12 lymphocytic lymphocytic JJ cord-005453-4057qib7 5216 13 leukemia leukemia NN cord-005453-4057qib7 5216 14 . . . cord-005453-4057qib7 5217 1 Induction induction NN cord-005453-4057qib7 5217 2 of of IN cord-005453-4057qib7 5217 3 apoptosis apoptosis NN cord-005453-4057qib7 5217 4 and and CC cord-005453-4057qib7 5217 5 depletion depletion NN cord-005453-4057qib7 5217 6 of of IN cord-005453-4057qib7 5217 7 lymphocyte lymphocyte NN cord-005453-4057qib7 5217 8 subpopulations subpopulation NNS cord-005453-4057qib7 5217 9 e.g. e.g. RB cord-005453-4057qib7 5217 10 follicular follicular JJ cord-005453-4057qib7 5217 11 B b NN cord-005453-4057qib7 5217 12 - - HYPH cord-005453-4057qib7 5217 13 cells cell NNS cord-005453-4057qib7 5217 14 or or CC cord-005453-4057qib7 5217 15 CD4 CD4 NNP cord-005453-4057qib7 5217 16 + + CC cord-005453-4057qib7 5217 17 and and CC cord-005453-4057qib7 5217 18 CD8 CD8 NNP cord-005453-4057qib7 5217 19 + + CC cord-005453-4057qib7 5217 20 T T NNP cord-005453-4057qib7 5217 21 - - HYPH cord-005453-4057qib7 5217 22 cells cell NNS cord-005453-4057qib7 5217 23 led lead VBD cord-005453-4057qib7 5217 24 to to IN cord-005453-4057qib7 5217 25 further further JJ cord-005453-4057qib7 5217 26 exploration exploration NN cord-005453-4057qib7 5217 27 in in IN cord-005453-4057qib7 5217 28 autoimmune autoimmune JJ cord-005453-4057qib7 5217 29 disease disease NN cord-005453-4057qib7 5217 30 . . . cord-005453-4057qib7 5218 1 Methods method NNS cord-005453-4057qib7 5218 2 : : : cord-005453-4057qib7 5218 3 To to TO cord-005453-4057qib7 5218 4 establish establish VB cord-005453-4057qib7 5218 5 expression expression NN cord-005453-4057qib7 5218 6 levels level NNS cord-005453-4057qib7 5218 7 of of IN cord-005453-4057qib7 5218 8 genes gene NNS cord-005453-4057qib7 5218 9 in in IN cord-005453-4057qib7 5218 10 the the DT cord-005453-4057qib7 5218 11 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5218 12 pathway pathway NN cord-005453-4057qib7 5218 13 , , , cord-005453-4057qib7 5218 14 low low JJ cord-005453-4057qib7 5218 15 - - HYPH cord-005453-4057qib7 5218 16 input input NN cord-005453-4057qib7 5218 17 RNA RNA NNP cord-005453-4057qib7 5218 18 sequencing sequencing NN cord-005453-4057qib7 5218 19 was be VBD cord-005453-4057qib7 5218 20 performed perform VBN cord-005453-4057qib7 5218 21 on on IN cord-005453-4057qib7 5218 22 T T NNP cord-005453-4057qib7 5218 23 cells cell NNS cord-005453-4057qib7 5218 24 isolated isolate VBN cord-005453-4057qib7 5218 25 from from IN cord-005453-4057qib7 5218 26 non non JJ cord-005453-4057qib7 5218 27 - - JJ cord-005453-4057qib7 5218 28 inflamed inflamed JJ cord-005453-4057qib7 5218 29 skin skin NN cord-005453-4057qib7 5218 30 and and CC cord-005453-4057qib7 5218 31 peripheral peripheral JJ cord-005453-4057qib7 5218 32 blood blood NN cord-005453-4057qib7 5218 33 of of IN cord-005453-4057qib7 5218 34 HSCT HSCT NNP cord-005453-4057qib7 5218 35 recipients recipient NNS cord-005453-4057qib7 5218 36 at at IN cord-005453-4057qib7 5218 37 5 5 CD cord-005453-4057qib7 5218 38 different different JJ cord-005453-4057qib7 5218 39 time time NN cord-005453-4057qib7 5218 40 points point NNS cord-005453-4057qib7 5218 41 before before RB cord-005453-4057qib7 5218 42 until until IN cord-005453-4057qib7 5218 43 1 1 CD cord-005453-4057qib7 5218 44 year year NN cord-005453-4057qib7 5218 45 after after IN cord-005453-4057qib7 5218 46 transplantation transplantation NN cord-005453-4057qib7 5218 47 . . . cord-005453-4057qib7 5219 1 Furthermore furthermore RB cord-005453-4057qib7 5219 2 , , , cord-005453-4057qib7 5219 3 we -PRON- PRP cord-005453-4057qib7 5219 4 analyzed analyze VBD cord-005453-4057qib7 5219 5 blood blood NN cord-005453-4057qib7 5219 6 , , , cord-005453-4057qib7 5219 7 lung lung NN cord-005453-4057qib7 5219 8 , , , cord-005453-4057qib7 5219 9 gut gut NN cord-005453-4057qib7 5219 10 and and CC cord-005453-4057qib7 5219 11 skin skin NN cord-005453-4057qib7 5219 12 samples sample NNS cord-005453-4057qib7 5219 13 of of IN cord-005453-4057qib7 5219 14 105 105 CD cord-005453-4057qib7 5219 15 patients patient NNS cord-005453-4057qib7 5219 16 post post VBP cord-005453-4057qib7 5219 17 allo allo NN cord-005453-4057qib7 5219 18 - - HYPH cord-005453-4057qib7 5219 19 HSCT HSCT NNP cord-005453-4057qib7 5219 20 with with IN cord-005453-4057qib7 5219 21 and and CC cord-005453-4057qib7 5219 22 without without IN cord-005453-4057qib7 5219 23 previously previously RB cord-005453-4057qib7 5219 24 untreated untreated JJ cord-005453-4057qib7 5219 25 acute acute JJ cord-005453-4057qib7 5219 26 or or CC cord-005453-4057qib7 5219 27 chronic chronic JJ cord-005453-4057qib7 5219 28 GVHD GVHD NNP cord-005453-4057qib7 5219 29 by by IN cord-005453-4057qib7 5219 30 RT RT NNP cord-005453-4057qib7 5219 31 - - HYPH cord-005453-4057qib7 5219 32 PCR PCR NNP cord-005453-4057qib7 5219 33 , , , cord-005453-4057qib7 5219 34 flow flow NN cord-005453-4057qib7 5219 35 cytometry cytometry NN cord-005453-4057qib7 5219 36 and and CC cord-005453-4057qib7 5219 37 tissue tissue NN cord-005453-4057qib7 5219 38 immunofluorescence immunofluorescence NN cord-005453-4057qib7 5219 39 . . . cord-005453-4057qib7 5220 1 [ [ -LRB- cord-005453-4057qib7 5220 2 [ [ -LRB- cord-005453-4057qib7 5220 3 P237 p237 CD cord-005453-4057qib7 5220 4 Image image NN cord-005453-4057qib7 5220 5 ] ] -RRB- cord-005453-4057qib7 5220 6 1 1 CD cord-005453-4057qib7 5220 7 . . . cord-005453-4057qib7 5221 1 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5221 2 is be VBZ cord-005453-4057qib7 5221 3 up up RB cord-005453-4057qib7 5221 4 - - HYPH cord-005453-4057qib7 5221 5 regulated regulate VBN cord-005453-4057qib7 5221 6 in in IN cord-005453-4057qib7 5221 7 T T NNP cord-005453-4057qib7 5221 8 and and CC cord-005453-4057qib7 5221 9 B b NN cord-005453-4057qib7 5221 10 lymphocytes lymphocyte NNS cord-005453-4057qib7 5221 11 of of IN cord-005453-4057qib7 5221 12 acute acute JJ cord-005453-4057qib7 5221 13 and and CC cord-005453-4057qib7 5221 14 chronic chronic JJ cord-005453-4057qib7 5221 15 GVHD GVHD NNP cord-005453-4057qib7 5221 16 lesions lesion NNS cord-005453-4057qib7 5221 17 . . . cord-005453-4057qib7 5221 18 ] ] -RRB- cord-005453-4057qib7 5222 1 Results result NNS cord-005453-4057qib7 5222 2 : : : cord-005453-4057qib7 5223 1 RNA rna NN cord-005453-4057qib7 5223 2 - - HYPH cord-005453-4057qib7 5223 3 sequencing sequencing NN cord-005453-4057qib7 5223 4 revealed reveal VBD cord-005453-4057qib7 5223 5 that that IN cord-005453-4057qib7 5223 6 T T NNP cord-005453-4057qib7 5223 7 cells cell NNS cord-005453-4057qib7 5223 8 upregulated upregulate VBD cord-005453-4057qib7 5223 9 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5223 10 upon upon IN cord-005453-4057qib7 5223 11 conditioning conditioning NN cord-005453-4057qib7 5223 12 treatment treatment NN cord-005453-4057qib7 5223 13 ( ( -LRB- cord-005453-4057qib7 5223 14 day day NN cord-005453-4057qib7 5223 15 0 0 CD cord-005453-4057qib7 5223 16 ) ) -RRB- cord-005453-4057qib7 5223 17 and and CC cord-005453-4057qib7 5223 18 cells cell NNS cord-005453-4057qib7 5223 19 of of IN cord-005453-4057qib7 5223 20 patients patient NNS cord-005453-4057qib7 5223 21 who who WP cord-005453-4057qib7 5223 22 later later RB cord-005453-4057qib7 5223 23 developed develop VBD cord-005453-4057qib7 5223 24 GVHD GVHD NNP cord-005453-4057qib7 5223 25 failed fail VBD cord-005453-4057qib7 5223 26 to to TO cord-005453-4057qib7 5223 27 downregulate downregulate VB cord-005453-4057qib7 5223 28 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5223 29 after after IN cord-005453-4057qib7 5223 30 transplantation transplantation NN cord-005453-4057qib7 5223 31 ( ( -LRB- cord-005453-4057qib7 5223 32 day+14 day+14 CD cord-005453-4057qib7 5223 33 , , , cord-005453-4057qib7 5223 34 day+100 day+100 NNP cord-005453-4057qib7 5223 35 ) ) -RRB- cord-005453-4057qib7 5223 36 . . . cord-005453-4057qib7 5224 1 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5224 2 protein protein NN cord-005453-4057qib7 5224 3 levels level NNS cord-005453-4057qib7 5224 4 were be VBD cord-005453-4057qib7 5224 5 elevated elevate VBN cord-005453-4057qib7 5224 6 in in IN cord-005453-4057qib7 5224 7 overall overall JJ cord-005453-4057qib7 5224 8 leukocytes leukocyte NNS cord-005453-4057qib7 5224 9 and and CC cord-005453-4057qib7 5224 10 pathogenic pathogenic JJ cord-005453-4057qib7 5224 11 cell cell NN cord-005453-4057qib7 5224 12 subsets subset NNS cord-005453-4057qib7 5224 13 including include VBG cord-005453-4057qib7 5224 14 monocytes monocyte NNS cord-005453-4057qib7 5224 15 , , , cord-005453-4057qib7 5224 16 CD8 CD8 NNP cord-005453-4057qib7 5224 17 + + CC cord-005453-4057qib7 5224 18 T T NNP cord-005453-4057qib7 5224 19 lymphocytes lymphocyte NNS cord-005453-4057qib7 5224 20 and and CC cord-005453-4057qib7 5224 21 NKT NKT NNP cord-005453-4057qib7 5224 22 cells cell NNS cord-005453-4057qib7 5224 23 showed show VBD cord-005453-4057qib7 5224 24 significantly significantly RB cord-005453-4057qib7 5224 25 higher high JJR cord-005453-4057qib7 5224 26 expression expression NN cord-005453-4057qib7 5224 27 of of IN cord-005453-4057qib7 5224 28 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5224 29 in in IN cord-005453-4057qib7 5224 30 peripheral peripheral JJ cord-005453-4057qib7 5224 31 blood blood NN cord-005453-4057qib7 5224 32 of of IN cord-005453-4057qib7 5224 33 GVHD GVHD NNP cord-005453-4057qib7 5224 34 patients patient NNS cord-005453-4057qib7 5224 35 as as IN cord-005453-4057qib7 5224 36 compared compare VBN cord-005453-4057qib7 5224 37 to to IN cord-005453-4057qib7 5224 38 healthy healthy JJ cord-005453-4057qib7 5224 39 controls control NNS cord-005453-4057qib7 5224 40 . . . cord-005453-4057qib7 5225 1 These these DT cord-005453-4057qib7 5225 2 results result NNS cord-005453-4057qib7 5225 3 could could MD cord-005453-4057qib7 5225 4 be be VB cord-005453-4057qib7 5225 5 recapitulated recapitulate VBN cord-005453-4057qib7 5225 6 in in IN cord-005453-4057qib7 5225 7 tissue tissue NN cord-005453-4057qib7 5225 8 samples sample NNS cord-005453-4057qib7 5225 9 , , , cord-005453-4057qib7 5225 10 where where WRB cord-005453-4057qib7 5225 11 disease disease NN cord-005453-4057qib7 5225 12 - - HYPH cord-005453-4057qib7 5225 13 promoting promote VBG cord-005453-4057qib7 5225 14 lymphocytes lymphocyte NNS cord-005453-4057qib7 5225 15 ( ( -LRB- cord-005453-4057qib7 5225 16 T T NNP cord-005453-4057qib7 5225 17 , , , cord-005453-4057qib7 5225 18 B B NNP cord-005453-4057qib7 5225 19 , , , cord-005453-4057qib7 5225 20 NK NK NNP cord-005453-4057qib7 5225 21 , , , cord-005453-4057qib7 5225 22 NKT NKT NNP cord-005453-4057qib7 5225 23 ) ) -RRB- cord-005453-4057qib7 5225 24 were be VBD cord-005453-4057qib7 5225 25 numerically numerically RB cord-005453-4057qib7 5225 26 expanded expand VBN cord-005453-4057qib7 5225 27 and and CC cord-005453-4057qib7 5225 28 expressed express VBD cord-005453-4057qib7 5225 29 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5225 30 in in IN cord-005453-4057qib7 5225 31 acute acute JJ cord-005453-4057qib7 5225 32 and and CC cord-005453-4057qib7 5225 33 chronic chronic JJ cord-005453-4057qib7 5225 34 GVHD GVHD NNP cord-005453-4057qib7 5225 35 skin skin NN cord-005453-4057qib7 5225 36 lesions lesion NNS cord-005453-4057qib7 5225 37 . . . cord-005453-4057qib7 5226 1 Notably notably RB cord-005453-4057qib7 5226 2 , , , cord-005453-4057qib7 5226 3 non non JJ cord-005453-4057qib7 5226 4 - - JJ cord-005453-4057qib7 5226 5 pathogenic pathogenic JJ cord-005453-4057qib7 5226 6 cell cell NN cord-005453-4057qib7 5226 7 types type NNS cord-005453-4057qib7 5226 8 such such JJ cord-005453-4057qib7 5226 9 as as IN cord-005453-4057qib7 5226 10 keratinocytes keratinocyte NNS cord-005453-4057qib7 5226 11 did do VBD cord-005453-4057qib7 5226 12 not not RB cord-005453-4057qib7 5226 13 exhibit exhibit VB cord-005453-4057qib7 5226 14 increased increase VBN cord-005453-4057qib7 5226 15 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5226 16 expression expression NN cord-005453-4057qib7 5226 17 compared compare VBN cord-005453-4057qib7 5226 18 to to TO cord-005453-4057qib7 5226 19 control control VB cord-005453-4057qib7 5226 20 samples sample NNS cord-005453-4057qib7 5226 21 from from IN cord-005453-4057qib7 5226 22 HSCT HSCT NNP cord-005453-4057qib7 5226 23 recipients recipient NNS cord-005453-4057qib7 5226 24 and and CC cord-005453-4057qib7 5226 25 healthy healthy JJ cord-005453-4057qib7 5226 26 donors donor NNS cord-005453-4057qib7 5226 27 . . . cord-005453-4057qib7 5227 1 While while IN cord-005453-4057qib7 5227 2 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5227 3 RNA RNA NNP cord-005453-4057qib7 5227 4 expression expression NN cord-005453-4057qib7 5227 5 did do VBD cord-005453-4057qib7 5227 6 not not RB cord-005453-4057qib7 5227 7 depend depend VB cord-005453-4057qib7 5227 8 on on IN cord-005453-4057qib7 5227 9 type type NN cord-005453-4057qib7 5227 10 of of IN cord-005453-4057qib7 5227 11 conditioning conditioning NN cord-005453-4057qib7 5227 12 ( ( -LRB- cord-005453-4057qib7 5227 13 MAC MAC NNP cord-005453-4057qib7 5227 14 vs. vs. FW cord-005453-4057qib7 5227 15 RIC RIC NNP cord-005453-4057qib7 5227 16 ) ) -RRB- cord-005453-4057qib7 5227 17 or or CC cord-005453-4057qib7 5227 18 GVHD GVHD NNP cord-005453-4057qib7 5227 19 grade grade NN cord-005453-4057qib7 5227 20 , , , cord-005453-4057qib7 5227 21 it -PRON- PRP cord-005453-4057qib7 5227 22 correlated correlate VBD cord-005453-4057qib7 5227 23 to to IN cord-005453-4057qib7 5227 24 disease disease NN cord-005453-4057qib7 5227 25 severity severity NN cord-005453-4057qib7 5227 26 and and CC cord-005453-4057qib7 5227 27 was be VBD cord-005453-4057qib7 5227 28 significantly significantly RB cord-005453-4057qib7 5227 29 elevated elevate VBN cord-005453-4057qib7 5227 30 in in IN cord-005453-4057qib7 5227 31 biopsies biopsy NNS cord-005453-4057qib7 5227 32 of of IN cord-005453-4057qib7 5227 33 patients patient NNS cord-005453-4057qib7 5227 34 with with IN cord-005453-4057qib7 5227 35 steroidrefractory steroidrefractory NNP cord-005453-4057qib7 5227 36 GVHD GVHD NNP cord-005453-4057qib7 5227 37 . . . cord-005453-4057qib7 5228 1 Conclusions conclusion NNS cord-005453-4057qib7 5228 2 : : : cord-005453-4057qib7 5229 1 We -PRON- PRP cord-005453-4057qib7 5229 2 could could MD cord-005453-4057qib7 5229 3 show show VB cord-005453-4057qib7 5229 4 exclusive exclusive JJ cord-005453-4057qib7 5229 5 upregulation upregulation NN cord-005453-4057qib7 5229 6 of of IN cord-005453-4057qib7 5229 7 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5229 8 in in IN cord-005453-4057qib7 5229 9 GVHD GVHD NNP cord-005453-4057qib7 5229 10 - - HYPH cord-005453-4057qib7 5229 11 mediating mediate VBG cord-005453-4057qib7 5229 12 cell cell NN cord-005453-4057qib7 5229 13 types type NNS cord-005453-4057qib7 5229 14 in in IN cord-005453-4057qib7 5229 15 peripheral peripheral JJ cord-005453-4057qib7 5229 16 blood blood NN cord-005453-4057qib7 5229 17 and and CC cord-005453-4057qib7 5229 18 tissue tissue NN cord-005453-4057qib7 5229 19 samples sample NNS cord-005453-4057qib7 5229 20 affected affect VBN cord-005453-4057qib7 5229 21 by by IN cord-005453-4057qib7 5229 22 GVHD GVHD NNP cord-005453-4057qib7 5229 23 , , , cord-005453-4057qib7 5229 24 correlating correlate VBG cord-005453-4057qib7 5229 25 to to IN cord-005453-4057qib7 5229 26 GVHD GVHD NNP cord-005453-4057qib7 5229 27 severity severity NN cord-005453-4057qib7 5229 28 and and CC cord-005453-4057qib7 5229 29 response response NN cord-005453-4057qib7 5229 30 to to IN cord-005453-4057qib7 5229 31 first first JJ cord-005453-4057qib7 5229 32 - - HYPH cord-005453-4057qib7 5229 33 line line NN cord-005453-4057qib7 5229 34 therapy therapy NN cord-005453-4057qib7 5229 35 . . . cord-005453-4057qib7 5230 1 Thus thus RB cord-005453-4057qib7 5230 2 , , , cord-005453-4057qib7 5230 3 Bcl-2 Bcl-2 NNP cord-005453-4057qib7 5230 4 inhibition inhibition NN cord-005453-4057qib7 5230 5 may may MD cord-005453-4057qib7 5230 6 present present VB cord-005453-4057qib7 5230 7 a a DT cord-005453-4057qib7 5230 8 novel novel NN cord-005453-4057qib7 5230 9 and and CC cord-005453-4057qib7 5230 10 urgently urgently RB cord-005453-4057qib7 5230 11 needed need VBN cord-005453-4057qib7 5230 12 targeted target VBN cord-005453-4057qib7 5230 13 therapy therapy NN cord-005453-4057qib7 5230 14 in in IN cord-005453-4057qib7 5230 15 treatment treatment NN cord-005453-4057qib7 5230 16 of of IN cord-005453-4057qib7 5230 17 steroid steroid NN cord-005453-4057qib7 5230 18 - - HYPH cord-005453-4057qib7 5230 19 refractory refractory JJ cord-005453-4057qib7 5230 20 acute acute NN cord-005453-4057qib7 5230 21 and and CC cord-005453-4057qib7 5230 22 chronic chronic JJ cord-005453-4057qib7 5230 23 GVHD GVHD NNP cord-005453-4057qib7 5230 24 . . . cord-005453-4057qib7 5231 1 Disclosure disclosure NN cord-005453-4057qib7 5231 2 : : : cord-005453-4057qib7 5231 3 Supported support VBN cord-005453-4057qib7 5231 4 by by IN cord-005453-4057qib7 5231 5 a a DT cord-005453-4057qib7 5231 6 DOCmed DOCmed NNP cord-005453-4057qib7 5231 7 fellowship fellowship NN cord-005453-4057qib7 5231 8 od od NN cord-005453-4057qib7 5231 9 the the DT cord-005453-4057qib7 5231 10 Austrain Austrain NNP cord-005453-4057qib7 5231 11 Academy Academy NNP cord-005453-4057qib7 5231 12 of of IN cord-005453-4057qib7 5231 13 Sciences Sciences NNPS cord-005453-4057qib7 5231 14 Background Background NNP cord-005453-4057qib7 5231 15 : : : cord-005453-4057qib7 5232 1 Graft graft NN cord-005453-4057qib7 5232 2 - - HYPH cord-005453-4057qib7 5232 3 versus versus IN cord-005453-4057qib7 5232 4 - - HYPH cord-005453-4057qib7 5232 5 host host NN cord-005453-4057qib7 5232 6 disease disease NN cord-005453-4057qib7 5232 7 ( ( -LRB- cord-005453-4057qib7 5232 8 GVHD GVHD NNP cord-005453-4057qib7 5232 9 ) ) -RRB- cord-005453-4057qib7 5232 10 represents represent VBZ cord-005453-4057qib7 5232 11 a a DT cord-005453-4057qib7 5232 12 major major JJ cord-005453-4057qib7 5232 13 contributor contributor NN cord-005453-4057qib7 5232 14 to to IN cord-005453-4057qib7 5232 15 morbidity morbidity NN cord-005453-4057qib7 5232 16 and and CC cord-005453-4057qib7 5232 17 mortality mortality NN cord-005453-4057qib7 5232 18 in in IN cord-005453-4057qib7 5232 19 recipients recipient NNS cord-005453-4057qib7 5232 20 of of IN cord-005453-4057qib7 5232 21 allogeneic allogeneic JJ cord-005453-4057qib7 5232 22 hematopoietic hematopoietic JJ cord-005453-4057qib7 5232 23 cell cell NN cord-005453-4057qib7 5232 24 transplants transplant NNS cord-005453-4057qib7 5232 25 ( ( -LRB- cord-005453-4057qib7 5232 26 HCT HCT NNP cord-005453-4057qib7 5232 27 ) ) -RRB- cord-005453-4057qib7 5232 28 . . . cord-005453-4057qib7 5233 1 Several several JJ cord-005453-4057qib7 5233 2 therapeutic therapeutic JJ cord-005453-4057qib7 5233 3 strategies strategy NNS cord-005453-4057qib7 5233 4 exist exist VBP cord-005453-4057qib7 5233 5 for for IN cord-005453-4057qib7 5233 6 GVHD GVHD NNP cord-005453-4057qib7 5233 7 prophylaxis prophylaxis NN cord-005453-4057qib7 5233 8 and and CC cord-005453-4057qib7 5233 9 include include VBP cord-005453-4057qib7 5233 10 post post JJ cord-005453-4057qib7 5233 11 - - JJ cord-005453-4057qib7 5233 12 transplant transplant NN cord-005453-4057qib7 5233 13 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 5233 14 ( ( -LRB- cord-005453-4057qib7 5233 15 PTCy PTCy NNP cord-005453-4057qib7 5233 16 ) ) -RRB- cord-005453-4057qib7 5233 17 and and CC cord-005453-4057qib7 5233 18 antithymocyte antithymocyte NNP cord-005453-4057qib7 5233 19 globulin globulin NNP cord-005453-4057qib7 5233 20 ( ( -LRB- cord-005453-4057qib7 5233 21 ATG ATG NNP cord-005453-4057qib7 5233 22 ) ) -RRB- cord-005453-4057qib7 5233 23 . . . cord-005453-4057qib7 5234 1 While while IN cord-005453-4057qib7 5234 2 several several JJ cord-005453-4057qib7 5234 3 groups group NNS cord-005453-4057qib7 5234 4 have have VBP cord-005453-4057qib7 5234 5 described describe VBN cord-005453-4057qib7 5234 6 the the DT cord-005453-4057qib7 5234 7 use use NN cord-005453-4057qib7 5234 8 of of IN cord-005453-4057qib7 5234 9 PTCy PTCy NNS cord-005453-4057qib7 5234 10 in in IN cord-005453-4057qib7 5234 11 younger young JJR cord-005453-4057qib7 5234 12 patients patient NNS cord-005453-4057qib7 5234 13 , , , cord-005453-4057qib7 5234 14 there there EX cord-005453-4057qib7 5234 15 is be VBZ cord-005453-4057qib7 5234 16 a a DT cord-005453-4057qib7 5234 17 paucity paucity NN cord-005453-4057qib7 5234 18 of of IN cord-005453-4057qib7 5234 19 data datum NNS cord-005453-4057qib7 5234 20 about about IN cord-005453-4057qib7 5234 21 the the DT cord-005453-4057qib7 5234 22 efficacy efficacy NN cord-005453-4057qib7 5234 23 of of IN cord-005453-4057qib7 5234 24 PTCy PTCy NNS cord-005453-4057qib7 5234 25 in in IN cord-005453-4057qib7 5234 26 older old JJR cord-005453-4057qib7 5234 27 individuals individual NNS cord-005453-4057qib7 5234 28 , , , cord-005453-4057qib7 5234 29 particularly particularly RB cord-005453-4057qib7 5234 30 when when WRB cord-005453-4057qib7 5234 31 combined combine VBN cord-005453-4057qib7 5234 32 with with IN cord-005453-4057qib7 5234 33 ATG ATG NNP cord-005453-4057qib7 5234 34 . . . cord-005453-4057qib7 5235 1 We -PRON- PRP cord-005453-4057qib7 5235 2 investigated investigate VBD cord-005453-4057qib7 5235 3 the the DT cord-005453-4057qib7 5235 4 combined combined JJ cord-005453-4057qib7 5235 5 effect effect NN cord-005453-4057qib7 5235 6 of of IN cord-005453-4057qib7 5235 7 PTCy PTCy NNS cord-005453-4057qib7 5235 8 with with IN cord-005453-4057qib7 5235 9 ATG ATG NNP cord-005453-4057qib7 5235 10 on on IN cord-005453-4057qib7 5235 11 transplant transplant NN cord-005453-4057qib7 5235 12 outcomes outcome NNS cord-005453-4057qib7 5235 13 in in IN cord-005453-4057qib7 5235 14 older old JJR cord-005453-4057qib7 5235 15 patients patient NNS cord-005453-4057qib7 5235 16 at at IN cord-005453-4057qib7 5235 17 Princess Princess NNP cord-005453-4057qib7 5235 18 Margaret Margaret NNP cord-005453-4057qib7 5235 19 Cancer Cancer NNP cord-005453-4057qib7 5235 20 Centre Centre NNP cord-005453-4057qib7 5235 21 , , , cord-005453-4057qib7 5235 22 Toronto Toronto NNP cord-005453-4057qib7 5235 23 , , , cord-005453-4057qib7 5235 24 Canada Canada NNP cord-005453-4057qib7 5235 25 . . . cord-005453-4057qib7 5236 1 Methods method NNS cord-005453-4057qib7 5236 2 : : : cord-005453-4057qib7 5237 1 This this DT cord-005453-4057qib7 5237 2 retrospective retrospective JJ cord-005453-4057qib7 5237 3 study study NN cord-005453-4057qib7 5237 4 included include VBD cord-005453-4057qib7 5237 5 all all DT cord-005453-4057qib7 5237 6 patients patient NNS cord-005453-4057qib7 5237 7 age age NN cord-005453-4057qib7 5237 8 ≥60 ≥60 XX cord-005453-4057qib7 5237 9 who who WP cord-005453-4057qib7 5237 10 underwent undergo VBD cord-005453-4057qib7 5237 11 allogeneic allogeneic JJ cord-005453-4057qib7 5237 12 HCT hct NN cord-005453-4057qib7 5237 13 for for IN cord-005453-4057qib7 5237 14 any any DT cord-005453-4057qib7 5237 15 indication indication NN cord-005453-4057qib7 5237 16 at at IN cord-005453-4057qib7 5237 17 our -PRON- PRP$ cord-005453-4057qib7 5237 18 centre centre NN cord-005453-4057qib7 5237 19 between between IN cord-005453-4057qib7 5237 20 December December NNP cord-005453-4057qib7 5237 21 2013 2013 CD cord-005453-4057qib7 5237 22 and and CC cord-005453-4057qib7 5237 23 July July NNP cord-005453-4057qib7 5237 24 2017 2017 CD cord-005453-4057qib7 5237 25 . . . cord-005453-4057qib7 5238 1 Overall overall JJ cord-005453-4057qib7 5238 2 survival survival NN cord-005453-4057qib7 5238 3 ( ( -LRB- cord-005453-4057qib7 5238 4 OS OS NNP cord-005453-4057qib7 5238 5 ) ) -RRB- cord-005453-4057qib7 5238 6 was be VBD cord-005453-4057qib7 5238 7 calculated calculate VBN cord-005453-4057qib7 5238 8 using use VBG cord-005453-4057qib7 5238 9 Kaplan Kaplan NNP cord-005453-4057qib7 5238 10 - - HYPH cord-005453-4057qib7 5238 11 Meier Meier NNP cord-005453-4057qib7 5238 12 analysis analysis NN cord-005453-4057qib7 5238 13 and and CC cord-005453-4057qib7 5238 14 multivariable multivariable JJ cord-005453-4057qib7 5238 15 Cox Cox NNP cord-005453-4057qib7 5238 16 proportional proportional JJ cord-005453-4057qib7 5238 17 hazards hazard NNS cord-005453-4057qib7 5238 18 regression regression NN cord-005453-4057qib7 5238 19 . . . cord-005453-4057qib7 5239 1 Cumulative cumulative JJ cord-005453-4057qib7 5239 2 incidence incidence NN cord-005453-4057qib7 5239 3 of of IN cord-005453-4057qib7 5239 4 relapse relapse NN cord-005453-4057qib7 5239 5 ( ( -LRB- cord-005453-4057qib7 5239 6 CIR CIR NNP cord-005453-4057qib7 5239 7 ) ) -RRB- cord-005453-4057qib7 5239 8 and and CC cord-005453-4057qib7 5239 9 non non JJ cord-005453-4057qib7 5239 10 - - JJ cord-005453-4057qib7 5239 11 relapse relapse JJ cord-005453-4057qib7 5239 12 mortality mortality NN cord-005453-4057qib7 5239 13 ( ( -LRB- cord-005453-4057qib7 5239 14 NRM NRM NNP cord-005453-4057qib7 5239 15 ) ) -RRB- cord-005453-4057qib7 5239 16 were be VBD cord-005453-4057qib7 5239 17 calculated calculate VBN cord-005453-4057qib7 5239 18 using use VBG cord-005453-4057qib7 5239 19 competing compete VBG cord-005453-4057qib7 5239 20 risk risk NN cord-005453-4057qib7 5239 21 regression regression NN cord-005453-4057qib7 5239 22 ( ( -LRB- cord-005453-4057qib7 5239 23 Fine fine JJ cord-005453-4057qib7 5239 24 and and CC cord-005453-4057qib7 5239 25 Gray gray JJ cord-005453-4057qib7 5239 26 method method NN cord-005453-4057qib7 5239 27 ) ) -RRB- cord-005453-4057qib7 5239 28 . . . cord-005453-4057qib7 5240 1 Incidences incidence NNS cord-005453-4057qib7 5240 2 of of IN cord-005453-4057qib7 5240 3 acute acute JJ cord-005453-4057qib7 5240 4 ( ( -LRB- cord-005453-4057qib7 5240 5 aGVHD aGVHD NNP cord-005453-4057qib7 5240 6 ) ) -RRB- cord-005453-4057qib7 5240 7 and and CC cord-005453-4057qib7 5240 8 chronic chronic JJ cord-005453-4057qib7 5240 9 ( ( -LRB- cord-005453-4057qib7 5240 10 cGVHD cGVHD NNP cord-005453-4057qib7 5240 11 ) ) -RRB- cord-005453-4057qib7 5240 12 were be VBD cord-005453-4057qib7 5240 13 compared compare VBN cord-005453-4057qib7 5240 14 using use VBG cord-005453-4057qib7 5240 15 the the DT cord-005453-4057qib7 5240 16 Fisher Fisher NNP cord-005453-4057qib7 5240 17 's 's POS cord-005453-4057qib7 5240 18 exact exact JJ cord-005453-4057qib7 5240 19 test test NN cord-005453-4057qib7 5240 20 . . . cord-005453-4057qib7 5241 1 Results result NNS cord-005453-4057qib7 5241 2 : : : cord-005453-4057qib7 5242 1 Of of IN cord-005453-4057qib7 5242 2 133 133 CD cord-005453-4057qib7 5242 3 patients patient NNS cord-005453-4057qib7 5242 4 , , , cord-005453-4057qib7 5242 5 84 84 CD cord-005453-4057qib7 5242 6 ( ( -LRB- cord-005453-4057qib7 5242 7 63 63 CD cord-005453-4057qib7 5242 8 % % NN cord-005453-4057qib7 5242 9 ) ) -RRB- cord-005453-4057qib7 5242 10 were be VBD cord-005453-4057qib7 5242 11 male male JJ cord-005453-4057qib7 5242 12 . . . cord-005453-4057qib7 5243 1 Median median JJ cord-005453-4057qib7 5243 2 age age NN cord-005453-4057qib7 5243 3 was be VBD cord-005453-4057qib7 5243 4 65 65 CD cord-005453-4057qib7 5244 1 ( ( -LRB- cord-005453-4057qib7 5244 2 range range NNP cord-005453-4057qib7 5244 3 60 60 CD cord-005453-4057qib7 5244 4 - - SYM cord-005453-4057qib7 5244 5 74 74 CD cord-005453-4057qib7 5244 6 ) ) -RRB- cord-005453-4057qib7 5244 7 and and CC cord-005453-4057qib7 5244 8 median median JJ cord-005453-4057qib7 5244 9 follow follow NN cord-005453-4057qib7 5244 10 - - HYPH cord-005453-4057qib7 5244 11 up up NN cord-005453-4057qib7 5244 12 among among IN cord-005453-4057qib7 5244 13 survivors survivor NNS cord-005453-4057qib7 5244 14 was be VBD cord-005453-4057qib7 5244 15 28 28 CD cord-005453-4057qib7 5244 16 months month NNS cord-005453-4057qib7 5244 17 ( ( -LRB- cord-005453-4057qib7 5244 18 range range VBP cord-005453-4057qib7 5244 19 6 6 CD cord-005453-4057qib7 5244 20 - - SYM cord-005453-4057qib7 5244 21 60 60 CD cord-005453-4057qib7 5244 22 ) ) -RRB- cord-005453-4057qib7 5244 23 . . . cord-005453-4057qib7 5245 1 Acute acute JJ cord-005453-4057qib7 5245 2 myeloid myeloid NN cord-005453-4057qib7 5245 3 leukaemia leukaemia NN cord-005453-4057qib7 5245 4 ( ( -LRB- cord-005453-4057qib7 5245 5 AML AML NNP cord-005453-4057qib7 5245 6 ) ) -RRB- cord-005453-4057qib7 5245 7 was be VBD cord-005453-4057qib7 5245 8 the the DT cord-005453-4057qib7 5245 9 most most RBS cord-005453-4057qib7 5245 10 common common JJ cord-005453-4057qib7 5245 11 indication indication NN cord-005453-4057qib7 5245 12 for for IN cord-005453-4057qib7 5245 13 HCT HCT NNP cord-005453-4057qib7 5245 14 ( ( -LRB- cord-005453-4057qib7 5245 15 57 57 CD cord-005453-4057qib7 5245 16 patients patient NNS cord-005453-4057qib7 5245 17 , , , cord-005453-4057qib7 5245 18 43 43 CD cord-005453-4057qib7 5245 19 % % NN cord-005453-4057qib7 5245 20 ) ) -RRB- cord-005453-4057qib7 5245 21 , , , cord-005453-4057qib7 5245 22 followed follow VBN cord-005453-4057qib7 5245 23 by by IN cord-005453-4057qib7 5245 24 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 5245 25 syndrome syndrome NN cord-005453-4057qib7 5245 26 ( ( -LRB- cord-005453-4057qib7 5245 27 37 37 CD cord-005453-4057qib7 5245 28 patients patient NNS cord-005453-4057qib7 5245 29 , , , cord-005453-4057qib7 5245 30 28 28 CD cord-005453-4057qib7 5245 31 % % NN cord-005453-4057qib7 5245 32 ) ) -RRB- cord-005453-4057qib7 5245 33 and and CC cord-005453-4057qib7 5245 34 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 5245 35 ( ( -LRB- cord-005453-4057qib7 5245 36 17 17 CD cord-005453-4057qib7 5245 37 patients patient NNS cord-005453-4057qib7 5245 38 , , , cord-005453-4057qib7 5245 39 13 13 CD cord-005453-4057qib7 5245 40 % % NN cord-005453-4057qib7 5245 41 ) ) -RRB- cord-005453-4057qib7 5245 42 . . . cord-005453-4057qib7 5246 1 Eightyfour Eightyfour NNP cord-005453-4057qib7 5246 2 ( ( -LRB- cord-005453-4057qib7 5246 3 63 63 CD cord-005453-4057qib7 5246 4 % % NN cord-005453-4057qib7 5246 5 ) ) -RRB- cord-005453-4057qib7 5247 1 patients patient NNS cord-005453-4057qib7 5247 2 had have VBD cord-005453-4057qib7 5247 3 a a DT cord-005453-4057qib7 5247 4 matched match VBN cord-005453-4057qib7 5247 5 unrelated unrelated JJ cord-005453-4057qib7 5247 6 donor donor NN cord-005453-4057qib7 5247 7 , , , cord-005453-4057qib7 5247 8 37 37 CD cord-005453-4057qib7 5247 9 ( ( -LRB- cord-005453-4057qib7 5247 10 28 28 CD cord-005453-4057qib7 5247 11 % % NN cord-005453-4057qib7 5247 12 ) ) -RRB- cord-005453-4057qib7 5247 13 had have VBD cord-005453-4057qib7 5247 14 a a DT cord-005453-4057qib7 5247 15 matched match VBN cord-005453-4057qib7 5247 16 related related JJ cord-005453-4057qib7 5247 17 donor donor NN cord-005453-4057qib7 5247 18 and and CC cord-005453-4057qib7 5247 19 12 12 CD cord-005453-4057qib7 5247 20 ( ( -LRB- cord-005453-4057qib7 5247 21 9 9 CD cord-005453-4057qib7 5247 22 % % NN cord-005453-4057qib7 5247 23 ) ) -RRB- cord-005453-4057qib7 5247 24 had have VBD cord-005453-4057qib7 5247 25 a a DT cord-005453-4057qib7 5247 26 haploidentical haploidentical JJ cord-005453-4057qib7 5247 27 donor donor NN cord-005453-4057qib7 5247 28 . . . cord-005453-4057qib7 5248 1 One one CD cord-005453-4057qib7 5248 2 hundred hundred CD cord-005453-4057qib7 5248 3 twenty twenty CD cord-005453-4057qib7 5248 4 - - HYPH cord-005453-4057qib7 5248 5 five five CD cord-005453-4057qib7 5248 6 ( ( -LRB- cord-005453-4057qib7 5248 7 94 94 CD cord-005453-4057qib7 5248 8 % % NN cord-005453-4057qib7 5248 9 ) ) -RRB- cord-005453-4057qib7 5248 10 patients patient NNS cord-005453-4057qib7 5248 11 received receive VBD cord-005453-4057qib7 5248 12 reduced reduced JJ cord-005453-4057qib7 5248 13 intensity intensity NN cord-005453-4057qib7 5248 14 conditioning conditioning NN cord-005453-4057qib7 5248 15 . . . cord-005453-4057qib7 5249 1 Sixty sixty CD cord-005453-4057qib7 5249 2 - - HYPH cord-005453-4057qib7 5249 3 two two CD cord-005453-4057qib7 5249 4 ( ( -LRB- cord-005453-4057qib7 5249 5 47 47 CD cord-005453-4057qib7 5249 6 % % NN cord-005453-4057qib7 5249 7 ) ) -RRB- cord-005453-4057qib7 5249 8 patients patient NNS cord-005453-4057qib7 5249 9 received receive VBD cord-005453-4057qib7 5249 10 PTCy PTCy NNS cord-005453-4057qib7 5249 11 combined combine VBN cord-005453-4057qib7 5249 12 with with IN cord-005453-4057qib7 5249 13 ATG ATG NNP cord-005453-4057qib7 5249 14 ( ( -LRB- cord-005453-4057qib7 5249 15 4.5 4.5 CD cord-005453-4057qib7 5249 16 mg mg NNP cord-005453-4057qib7 5249 17 / / SYM cord-005453-4057qib7 5249 18 kg kg NNP cord-005453-4057qib7 5249 19 ) ) -RRB- cord-005453-4057qib7 5249 20 while while IN cord-005453-4057qib7 5249 21 71 71 CD cord-005453-4057qib7 5249 22 ( ( -LRB- cord-005453-4057qib7 5249 23 53 53 CD cord-005453-4057qib7 5249 24 % % NN cord-005453-4057qib7 5249 25 ) ) -RRB- cord-005453-4057qib7 5249 26 received receive VBD cord-005453-4057qib7 5249 27 other other JJ cord-005453-4057qib7 5249 28 forms form NNS cord-005453-4057qib7 5249 29 of of IN cord-005453-4057qib7 5249 30 GVHD GVHD NNP cord-005453-4057qib7 5249 31 prophylaxis prophylaxis NN cord-005453-4057qib7 5249 32 . . . cord-005453-4057qib7 5250 1 OS OS NNP cord-005453-4057qib7 5250 2 at at IN cord-005453-4057qib7 5250 3 2 2 CD cord-005453-4057qib7 5250 4 years year NNS cord-005453-4057qib7 5250 5 was be VBD cord-005453-4057qib7 5250 6 46 46 CD cord-005453-4057qib7 5250 7 % % NN cord-005453-4057qib7 5250 8 ( ( -LRB- cord-005453-4057qib7 5250 9 95 95 CD cord-005453-4057qib7 5250 10 % % NN cord-005453-4057qib7 5250 11 confidence confidence NN cord-005453-4057qib7 5250 12 interval interval NN cord-005453-4057qib7 5250 13 ( ( -LRB- cord-005453-4057qib7 5250 14 CI CI NNP cord-005453-4057qib7 5250 15 ) ) -RRB- cord-005453-4057qib7 5250 16 37 37 CD cord-005453-4057qib7 5250 17 - - SYM cord-005453-4057qib7 5250 18 54 54 CD cord-005453-4057qib7 5250 19 ) ) -RRB- cord-005453-4057qib7 5250 20 in in IN cord-005453-4057qib7 5250 21 the the DT cord-005453-4057qib7 5250 22 entire entire JJ cord-005453-4057qib7 5250 23 cohort cohort NN cord-005453-4057qib7 5250 24 . . . cord-005453-4057qib7 5251 1 Patients patient NNS cord-005453-4057qib7 5251 2 who who WP cord-005453-4057qib7 5251 3 received receive VBD cord-005453-4057qib7 5251 4 PTCy PTCy NNS cord-005453-4057qib7 5251 5 with with IN cord-005453-4057qib7 5251 6 ATG ATG NNP cord-005453-4057qib7 5251 7 had have VBD cord-005453-4057qib7 5251 8 a a DT cord-005453-4057qib7 5251 9 superior superior JJ cord-005453-4057qib7 5251 10 2-year 2-year CD cord-005453-4057qib7 5251 11 OS os NN cord-005453-4057qib7 5251 12 compared compare VBN cord-005453-4057qib7 5251 13 with with IN cord-005453-4057qib7 5251 14 other other JJ cord-005453-4057qib7 5251 15 GVHD GVHD NNP cord-005453-4057qib7 5251 16 prophylaxis prophylaxis NN cord-005453-4057qib7 5251 17 regimens regimen NNS cord-005453-4057qib7 5251 18 ( ( -LRB- cord-005453-4057qib7 5251 19 Figure figure NN cord-005453-4057qib7 5251 20 1A 1a NN cord-005453-4057qib7 5251 21 ): ): NNP cord-005453-4057qib7 5251 22 57 57 CD cord-005453-4057qib7 5251 23 % % NN cord-005453-4057qib7 5251 24 ( ( -LRB- cord-005453-4057qib7 5251 25 95 95 CD cord-005453-4057qib7 5251 26 % % NN cord-005453-4057qib7 5251 27 CI CI NNP cord-005453-4057qib7 5251 28 44 44 CD cord-005453-4057qib7 5251 29 - - SYM cord-005453-4057qib7 5251 30 69 69 CD cord-005453-4057qib7 5251 31 ) ) -RRB- cord-005453-4057qib7 5251 32 vs. vs. IN cord-005453-4057qib7 5251 33 37 37 CD cord-005453-4057qib7 5251 34 % % NN cord-005453-4057qib7 5251 35 ( ( -LRB- cord-005453-4057qib7 5251 36 95 95 CD cord-005453-4057qib7 5251 37 % % NN cord-005453-4057qib7 5251 38 CI CI NNP cord-005453-4057qib7 5251 39 26 26 CD cord-005453-4057qib7 5251 40 - - SYM cord-005453-4057qib7 5251 41 49 49 CD cord-005453-4057qib7 5251 42 ) ) -RRB- cord-005453-4057qib7 5251 43 , , , cord-005453-4057qib7 5251 44 respectively respectively RB cord-005453-4057qib7 5251 45 ( ( -LRB- cord-005453-4057qib7 5251 46 HR=0.6 hr=0.6 NN cord-005453-4057qib7 5251 47 , , , cord-005453-4057qib7 5251 48 95 95 CD cord-005453-4057qib7 5251 49 % % NN cord-005453-4057qib7 5251 50 CI CI NNP cord-005453-4057qib7 5251 51 0.4 0.4 CD cord-005453-4057qib7 5251 52 - - SYM cord-005453-4057qib7 5251 53 0.9 0.9 CD cord-005453-4057qib7 5251 54 , , , cord-005453-4057qib7 5251 55 P=0.02 P=0.02 NNP cord-005453-4057qib7 5251 56 ) ) -RRB- cord-005453-4057qib7 5251 57 . . . cord-005453-4057qib7 5252 1 The the DT cord-005453-4057qib7 5252 2 2-year 2-year CD cord-005453-4057qib7 5252 3 NRM NRM NNP cord-005453-4057qib7 5252 4 for for IN cord-005453-4057qib7 5252 5 the the DT cord-005453-4057qib7 5252 6 entire entire JJ cord-005453-4057qib7 5252 7 cohort cohort NN cord-005453-4057qib7 5252 8 was be VBD cord-005453-4057qib7 5252 9 37 37 CD cord-005453-4057qib7 5252 10 % % NN cord-005453-4057qib7 5252 11 ( ( -LRB- cord-005453-4057qib7 5252 12 95 95 CD cord-005453-4057qib7 5252 13 % % NN cord-005453-4057qib7 5252 14 CI CI NNP cord-005453-4057qib7 5252 15 , , , cord-005453-4057qib7 5252 16 29 29 CD cord-005453-4057qib7 5252 17 - - SYM cord-005453-4057qib7 5252 18 46 46 CD cord-005453-4057qib7 5252 19 ) ) -RRB- cord-005453-4057qib7 5252 20 . . . cord-005453-4057qib7 5253 1 Patients patient NNS cord-005453-4057qib7 5253 2 who who WP cord-005453-4057qib7 5253 3 received receive VBD cord-005453-4057qib7 5253 4 PTCy PTCy NNS cord-005453-4057qib7 5253 5 with with IN cord-005453-4057qib7 5253 6 ATG ATG NNP cord-005453-4057qib7 5253 7 had have VBD cord-005453-4057qib7 5253 8 a a DT cord-005453-4057qib7 5253 9 lower low JJR cord-005453-4057qib7 5253 10 2-year 2-year CD cord-005453-4057qib7 5253 11 NRM NRM NNP cord-005453-4057qib7 5253 12 compared compare VBN cord-005453-4057qib7 5253 13 to to IN cord-005453-4057qib7 5253 14 those those DT cord-005453-4057qib7 5253 15 who who WP cord-005453-4057qib7 5253 16 did do VBD cord-005453-4057qib7 5253 17 not not RB cord-005453-4057qib7 5253 18 ( ( -LRB- cord-005453-4057qib7 5253 19 Figure figure NN cord-005453-4057qib7 5253 20 1B 1b CD cord-005453-4057qib7 5254 1 ): ): NNP cord-005453-4057qib7 5255 1 23 23 CD cord-005453-4057qib7 5255 2 % % NN cord-005453-4057qib7 5255 3 ( ( -LRB- cord-005453-4057qib7 5255 4 95 95 CD cord-005453-4057qib7 5255 5 % % NN cord-005453-4057qib7 5255 6 CI CI NNP cord-005453-4057qib7 5255 7 13 13 CD cord-005453-4057qib7 5255 8 - - SYM cord-005453-4057qib7 5255 9 34 34 CD cord-005453-4057qib7 5255 10 ) ) -RRB- cord-005453-4057qib7 5255 11 vs. vs. IN cord-005453-4057qib7 5255 12 49 49 CD cord-005453-4057qib7 5255 13 % % NN cord-005453-4057qib7 5255 14 ( ( -LRB- cord-005453-4057qib7 5255 15 95 95 CD cord-005453-4057qib7 5255 16 % % NN cord-005453-4057qib7 5255 17 CI CI NNP cord-005453-4057qib7 5255 18 37 37 CD cord-005453-4057qib7 5255 19 - - SYM cord-005453-4057qib7 5255 20 60 60 CD cord-005453-4057qib7 5255 21 ) ) -RRB- cord-005453-4057qib7 5255 22 , , , cord-005453-4057qib7 5255 23 respectively respectively RB cord-005453-4057qib7 5255 24 ( ( -LRB- cord-005453-4057qib7 5255 25 HR=0.4 HR=0.4 NNS cord-005453-4057qib7 5255 26 , , , cord-005453-4057qib7 5255 27 95 95 CD cord-005453-4057qib7 5255 28 % % NN cord-005453-4057qib7 5255 29 CI CI NNP cord-005453-4057qib7 5255 30 0.2 0.2 CD cord-005453-4057qib7 5255 31 - - SYM cord-005453-4057qib7 5255 32 0.7 0.7 CD cord-005453-4057qib7 5255 33 , , , cord-005453-4057qib7 5255 34 P=0.002 P=0.002 NNP cord-005453-4057qib7 5255 35 ) ) -RRB- cord-005453-4057qib7 5255 36 . . . cord-005453-4057qib7 5256 1 The the DT cord-005453-4057qib7 5256 2 2-year 2-year CD cord-005453-4057qib7 5256 3 CIR CIR NNP cord-005453-4057qib7 5256 4 in in IN cord-005453-4057qib7 5256 5 the the DT cord-005453-4057qib7 5256 6 whole whole JJ cord-005453-4057qib7 5256 7 group group NN cord-005453-4057qib7 5256 8 was be VBD cord-005453-4057qib7 5256 9 24 24 CD cord-005453-4057qib7 5256 10 % % NN cord-005453-4057qib7 5256 11 ( ( -LRB- cord-005453-4057qib7 5256 12 95 95 CD cord-005453-4057qib7 5256 13 % % NN cord-005453-4057qib7 5256 14 CI CI NNP cord-005453-4057qib7 5256 15 17 17 CD cord-005453-4057qib7 5256 16 - - SYM cord-005453-4057qib7 5256 17 32 32 CD cord-005453-4057qib7 5256 18 ) ) -RRB- cord-005453-4057qib7 5256 19 . . . cord-005453-4057qib7 5257 1 Use Use NNP cord-005453-4057qib7 5257 2 of of IN cord-005453-4057qib7 5257 3 PTCy PTCy NNPS cord-005453-4057qib7 5257 4 with with IN cord-005453-4057qib7 5257 5 ATG ATG NNP cord-005453-4057qib7 5257 6 was be VBD cord-005453-4057qib7 5257 7 associated associate VBN cord-005453-4057qib7 5257 8 with with IN cord-005453-4057qib7 5257 9 a a DT cord-005453-4057qib7 5257 10 modest modest JJ cord-005453-4057qib7 5257 11 increase increase NN cord-005453-4057qib7 5257 12 in in IN cord-005453-4057qib7 5257 13 CIR CIR NNP cord-005453-4057qib7 5257 14 at at IN cord-005453-4057qib7 5257 15 two two CD cord-005453-4057qib7 5257 16 years year NNS cord-005453-4057qib7 5257 17 ( ( -LRB- cord-005453-4057qib7 5257 18 Figure figure NN cord-005453-4057qib7 5257 19 _SP cord-005453-4057qib7 5257 20 1C 1C NNP cord-005453-4057qib7 5257 21 ): ): NNP cord-005453-4057qib7 5257 22 35 35 CD cord-005453-4057qib7 5257 23 % % NN cord-005453-4057qib7 5257 24 ( ( -LRB- cord-005453-4057qib7 5257 25 95 95 CD cord-005453-4057qib7 5257 26 % % NN cord-005453-4057qib7 5257 27 CI CI NNP cord-005453-4057qib7 5257 28 22 22 CD cord-005453-4057qib7 5257 29 - - SYM cord-005453-4057qib7 5257 30 49 49 CD cord-005453-4057qib7 5257 31 ) ) -RRB- cord-005453-4057qib7 5257 32 vs. vs. IN cord-005453-4057qib7 5257 33 16 16 CD cord-005453-4057qib7 5257 34 % % NN cord-005453-4057qib7 5257 35 ( ( -LRB- cord-005453-4057qib7 5257 36 95 95 CD cord-005453-4057qib7 5257 37 % % NN cord-005453-4057qib7 5257 38 8 8 CD cord-005453-4057qib7 5257 39 - - SYM cord-005453-4057qib7 5257 40 25 25 CD cord-005453-4057qib7 5257 41 ) ) -RRB- cord-005453-4057qib7 5257 42 , , , cord-005453-4057qib7 5257 43 respectively respectively RB cord-005453-4057qib7 5257 44 ( ( -LRB- cord-005453-4057qib7 5257 45 HR=2.1 hr=2.1 NN cord-005453-4057qib7 5258 1 , , , cord-005453-4057qib7 5258 2 95 95 CD cord-005453-4057qib7 5258 3 % % NN cord-005453-4057qib7 5258 4 CI CI NNP cord-005453-4057qib7 5258 5 1.0 1.0 CD cord-005453-4057qib7 5258 6 - - SYM cord-005453-4057qib7 5258 7 4.0 4.0 CD cord-005453-4057qib7 5258 8 , , , cord-005453-4057qib7 5258 9 P=0.04 P=0.04 NNP cord-005453-4057qib7 5258 10 ) ) -RRB- cord-005453-4057qib7 5258 11 . . . cord-005453-4057qib7 5259 1 There there EX cord-005453-4057qib7 5259 2 was be VBD cord-005453-4057qib7 5259 3 a a DT cord-005453-4057qib7 5259 4 trend trend NN cord-005453-4057qib7 5259 5 toward toward IN cord-005453-4057qib7 5259 6 lower low JJR cord-005453-4057qib7 5259 7 incidence incidence NN cord-005453-4057qib7 5259 8 of of IN cord-005453-4057qib7 5259 9 grade grade NN cord-005453-4057qib7 5259 10 II II NNP cord-005453-4057qib7 5259 11 - - HYPH cord-005453-4057qib7 5259 12 IV IV NNP cord-005453-4057qib7 5259 13 aGVHD agvhd NN cord-005453-4057qib7 5259 14 among among IN cord-005453-4057qib7 5259 15 patients patient NNS cord-005453-4057qib7 5259 16 who who WP cord-005453-4057qib7 5259 17 received receive VBD cord-005453-4057qib7 5259 18 PTCy PTCy NNS cord-005453-4057qib7 5259 19 with with IN cord-005453-4057qib7 5259 20 ATG ATG NNP cord-005453-4057qib7 5259 21 compared compare VBN cord-005453-4057qib7 5259 22 to to IN cord-005453-4057qib7 5259 23 those those DT cord-005453-4057qib7 5259 24 who who WP cord-005453-4057qib7 5259 25 did do VBD cord-005453-4057qib7 5259 26 not not RB cord-005453-4057qib7 5259 27 : : : cord-005453-4057qib7 5259 28 15 15 CD cord-005453-4057qib7 5259 29 % % NN cord-005453-4057qib7 5259 30 vs. vs. CC cord-005453-4057qib7 5259 31 30 30 CD cord-005453-4057qib7 5259 32 % % NN cord-005453-4057qib7 5259 33 ( ( -LRB- cord-005453-4057qib7 5259 34 P=0.06 P=0.06 NNP cord-005453-4057qib7 5259 35 ) ) -RRB- cord-005453-4057qib7 5259 36 . . . cord-005453-4057qib7 5260 1 The the DT cord-005453-4057qib7 5260 2 incidence incidence NN cord-005453-4057qib7 5260 3 of of IN cord-005453-4057qib7 5260 4 grade grade NN cord-005453-4057qib7 5260 5 II II NNP cord-005453-4057qib7 5260 6 - - HYPH cord-005453-4057qib7 5260 7 IV IV NNP cord-005453-4057qib7 5260 8 cGVHD cGVHD NNP cord-005453-4057qib7 5260 9 was be VBD cord-005453-4057qib7 5260 10 lower low JJR cord-005453-4057qib7 5260 11 in in IN cord-005453-4057qib7 5260 12 individuals individual NNS cord-005453-4057qib7 5260 13 who who WP cord-005453-4057qib7 5260 14 received receive VBD cord-005453-4057qib7 5260 15 PTCy PTCy NNS cord-005453-4057qib7 5260 16 with with IN cord-005453-4057qib7 5260 17 ATG ATG NNP cord-005453-4057qib7 5260 18 compared compare VBN cord-005453-4057qib7 5260 19 to to IN cord-005453-4057qib7 5260 20 those those DT cord-005453-4057qib7 5260 21 who who WP cord-005453-4057qib7 5260 22 did do VBD cord-005453-4057qib7 5260 23 not not RB cord-005453-4057qib7 5260 24 : : : cord-005453-4057qib7 5260 25 26 26 CD cord-005453-4057qib7 5260 26 % % NN cord-005453-4057qib7 5260 27 vs. vs. IN cord-005453-4057qib7 5260 28 45 45 CD cord-005453-4057qib7 5260 29 % % NN cord-005453-4057qib7 5260 30 ( ( -LRB- cord-005453-4057qib7 5260 31 P=0.03 p=0.03 NN cord-005453-4057qib7 5260 32 ) ) -RRB- cord-005453-4057qib7 5260 33 . . . cord-005453-4057qib7 5261 1 Conclusions conclusion NNS cord-005453-4057qib7 5261 2 : : : cord-005453-4057qib7 5262 1 In in IN cord-005453-4057qib7 5262 2 older old JJR cord-005453-4057qib7 5262 3 HCT hct NN cord-005453-4057qib7 5262 4 recipients recipient NNS cord-005453-4057qib7 5262 5 , , , cord-005453-4057qib7 5262 6 use use NN cord-005453-4057qib7 5262 7 of of IN cord-005453-4057qib7 5262 8 PTCy PTCy NNS cord-005453-4057qib7 5262 9 combined combine VBN cord-005453-4057qib7 5262 10 with with IN cord-005453-4057qib7 5262 11 ATG ATG NNP cord-005453-4057qib7 5262 12 is be VBZ cord-005453-4057qib7 5262 13 associated associate VBN cord-005453-4057qib7 5262 14 with with IN cord-005453-4057qib7 5262 15 improved improved JJ cord-005453-4057qib7 5262 16 OS OS NNP cord-005453-4057qib7 5262 17 , , , cord-005453-4057qib7 5262 18 lower low JJR cord-005453-4057qib7 5262 19 NRM NRM NNP cord-005453-4057qib7 5262 20 , , , cord-005453-4057qib7 5262 21 decreased decrease VBD cord-005453-4057qib7 5262 22 risk risk NN cord-005453-4057qib7 5262 23 of of IN cord-005453-4057qib7 5262 24 both both CC cord-005453-4057qib7 5262 25 aGVHD aGVHD NNP cord-005453-4057qib7 5262 26 and and CC cord-005453-4057qib7 5262 27 cGVHD cGVHD NNP cord-005453-4057qib7 5262 28 and and CC cord-005453-4057qib7 5262 29 a a DT cord-005453-4057qib7 5262 30 modest modest JJ cord-005453-4057qib7 5262 31 increase increase NN cord-005453-4057qib7 5262 32 in in IN cord-005453-4057qib7 5262 33 relapse relapse NN cord-005453-4057qib7 5262 34 risk risk NN cord-005453-4057qib7 5262 35 . . . cord-005453-4057qib7 5263 1 Therefore therefore RB cord-005453-4057qib7 5263 2 the the DT cord-005453-4057qib7 5263 3 PTCy PTCy NNS cord-005453-4057qib7 5263 4 with with IN cord-005453-4057qib7 5263 5 ATG ATG NNP cord-005453-4057qib7 5263 6 combination combination NN cord-005453-4057qib7 5263 7 represents represent VBZ cord-005453-4057qib7 5263 8 an an DT cord-005453-4057qib7 5263 9 effective effective JJ cord-005453-4057qib7 5263 10 strategy strategy NN cord-005453-4057qib7 5263 11 for for IN cord-005453-4057qib7 5263 12 GVHD GVHD NNP cord-005453-4057qib7 5263 13 prophylaxis prophylaxis NN cord-005453-4057qib7 5263 14 in in IN cord-005453-4057qib7 5263 15 older old JJR cord-005453-4057qib7 5263 16 allogeneic allogeneic IN cord-005453-4057qib7 5263 17 HCT hct NN cord-005453-4057qib7 5263 18 recipients recipient NNS cord-005453-4057qib7 5263 19 . . . cord-005453-4057qib7 5264 1 Disclosure disclosure NN cord-005453-4057qib7 5264 2 : : : cord-005453-4057qib7 5265 1 The the DT cord-005453-4057qib7 5265 2 authors author NNS cord-005453-4057qib7 5265 3 have have VBP cord-005453-4057qib7 5265 4 no no DT cord-005453-4057qib7 5265 5 conflict conflict NN cord-005453-4057qib7 5265 6 of of IN cord-005453-4057qib7 5265 7 interest interest NN cord-005453-4057qib7 5265 8 to to TO cord-005453-4057qib7 5265 9 declare declare VB cord-005453-4057qib7 5265 10 . . . cord-005453-4057qib7 5266 1 Outcome outcome NN cord-005453-4057qib7 5266 2 of of IN cord-005453-4057qib7 5266 3 severe severe JJ cord-005453-4057qib7 5266 4 graft graft NN cord-005453-4057qib7 5266 5 versus versus IN cord-005453-4057qib7 5266 6 host host NN cord-005453-4057qib7 5266 7 disease disease NN cord-005453-4057qib7 5266 8 in in IN cord-005453-4057qib7 5266 9 pediatric pediatric JJ cord-005453-4057qib7 5266 10 patients patient NNS cord-005453-4057qib7 5266 11 with with IN cord-005453-4057qib7 5266 12 nonmalignant nonmalignant JJ cord-005453-4057qib7 5266 13 diseases disease NNS cord-005453-4057qib7 5266 14 after after IN cord-005453-4057qib7 5266 15 allogeneic allogeneic NN cord-005453-4057qib7 5266 16 bone bone NN cord-005453-4057qib7 5266 17 marrow marrow NN cord-005453-4057qib7 5266 18 transplantation transplantation NN cord-005453-4057qib7 5266 19 . . . cord-005453-4057qib7 5267 1 A a DT cord-005453-4057qib7 5267 2 single single JJ cord-005453-4057qib7 5267 3 center center NN cord-005453-4057qib7 5267 4 experience experience NN cord-005453-4057qib7 5267 5 Irina Irina NNP cord-005453-4057qib7 5267 6 Zaidman Zaidman NNP cord-005453-4057qib7 5267 7 1 1 CD cord-005453-4057qib7 5267 8 , , , cord-005453-4057qib7 5267 9 Sigal Sigal NNP cord-005453-4057qib7 5267 10 Grisariu Grisariu NNP cord-005453-4057qib7 5267 11 1 1 CD cord-005453-4057qib7 5267 12 , , , cord-005453-4057qib7 5267 13 Batia Batia NNP cord-005453-4057qib7 5267 14 Avni Avni NNP cord-005453-4057qib7 5267 15 1 1 CD cord-005453-4057qib7 5267 16 , , , cord-005453-4057qib7 5268 1 Ehud Ehud NNP cord-005453-4057qib7 5268 2 Even even RB cord-005453-4057qib7 5268 3 - - : cord-005453-4057qib7 5268 4 Or or CC cord-005453-4057qib7 5268 5 1 1 CD cord-005453-4057qib7 5268 6 , , , cord-005453-4057qib7 5268 7 Bella Bella NNP cord-005453-4057qib7 5268 8 Shadur Shadur NNP cord-005453-4057qib7 5268 9 1 1 CD cord-005453-4057qib7 5268 10 , , , cord-005453-4057qib7 5268 11 Adeeb Adeeb NNP cord-005453-4057qib7 5268 12 Nasereddin Nasereddin NNP cord-005453-4057qib7 5268 13 1 1 CD cord-005453-4057qib7 5268 14 , , , cord-005453-4057qib7 5268 15 Polina Polina NNP cord-005453-4057qib7 5268 16 Stepensky Stepensky NNP cord-005453-4057qib7 5268 17 1 1 CD cord-005453-4057qib7 5268 18 Background Background NNP cord-005453-4057qib7 5268 19 : : : cord-005453-4057qib7 5269 1 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 5269 2 Stem Stem NNP cord-005453-4057qib7 5269 3 Cell cell NN cord-005453-4057qib7 5269 4 Transplantation transplantation NN cord-005453-4057qib7 5269 5 ( ( -LRB- cord-005453-4057qib7 5269 6 HSCT HSCT NNP cord-005453-4057qib7 5269 7 ) ) -RRB- cord-005453-4057qib7 5269 8 remained remain VBD cord-005453-4057qib7 5269 9 the the DT cord-005453-4057qib7 5269 10 only only JJ cord-005453-4057qib7 5269 11 curative curative JJ cord-005453-4057qib7 5269 12 option option NN cord-005453-4057qib7 5269 13 for for IN cord-005453-4057qib7 5269 14 many many JJ cord-005453-4057qib7 5269 15 nonmalignant nonmalignant JJ cord-005453-4057qib7 5269 16 diseases disease NNS cord-005453-4057qib7 5269 17 in in IN cord-005453-4057qib7 5269 18 pediatric pediatric JJ cord-005453-4057qib7 5269 19 patients patient NNS cord-005453-4057qib7 5269 20 . . . cord-005453-4057qib7 5270 1 Survival survival NN cord-005453-4057qib7 5270 2 after after IN cord-005453-4057qib7 5270 3 HSCT HSCT NNP cord-005453-4057qib7 5270 4 has have VBZ cord-005453-4057qib7 5270 5 improved improve VBN cord-005453-4057qib7 5270 6 the the DT cord-005453-4057qib7 5270 7 last last JJ cord-005453-4057qib7 5270 8 few few JJ cord-005453-4057qib7 5270 9 years year NNS cord-005453-4057qib7 5270 10 due due JJ cord-005453-4057qib7 5270 11 to to IN cord-005453-4057qib7 5270 12 significant significant JJ cord-005453-4057qib7 5270 13 advancement advancement NN cord-005453-4057qib7 5270 14 in in IN cord-005453-4057qib7 5270 15 human human JJ cord-005453-4057qib7 5270 16 leukocyte leukocyte NN cord-005453-4057qib7 5270 17 antigens antigen NNS cord-005453-4057qib7 5270 18 ( ( -LRB- cord-005453-4057qib7 5270 19 HLA HLA NNP cord-005453-4057qib7 5270 20 ) ) -RRB- cord-005453-4057qib7 5270 21 typing typing NN cord-005453-4057qib7 5270 22 techniques technique NNS cord-005453-4057qib7 5270 23 , , , cord-005453-4057qib7 5270 24 less less RBR cord-005453-4057qib7 5270 25 toxic toxic JJ cord-005453-4057qib7 5270 26 conditioning conditioning NN cord-005453-4057qib7 5270 27 regimens regimen NNS cord-005453-4057qib7 5270 28 and and CC cord-005453-4057qib7 5270 29 better well JJR cord-005453-4057qib7 5270 30 supportive supportive JJ cord-005453-4057qib7 5270 31 care care NN cord-005453-4057qib7 5270 32 and and CC cord-005453-4057qib7 5270 33 resulted result VBD cord-005453-4057qib7 5270 34 to to IN cord-005453-4057qib7 5270 35 90 90 CD cord-005453-4057qib7 5270 36 % % NN cord-005453-4057qib7 5270 37 survival survival NN cord-005453-4057qib7 5270 38 and and CC cord-005453-4057qib7 5270 39 cure cure NN cord-005453-4057qib7 5270 40 in in IN cord-005453-4057qib7 5270 41 some some DT cord-005453-4057qib7 5270 42 non non JJ cord-005453-4057qib7 5270 43 malignant malignant JJ cord-005453-4057qib7 5270 44 diseases disease NNS cord-005453-4057qib7 5270 45 . . . cord-005453-4057qib7 5271 1 Graft graft NN cord-005453-4057qib7 5271 2 - - HYPH cord-005453-4057qib7 5271 3 versus versus IN cord-005453-4057qib7 5271 4 - - HYPH cord-005453-4057qib7 5271 5 host host NN cord-005453-4057qib7 5271 6 disease disease NN cord-005453-4057qib7 5271 7 ( ( -LRB- cord-005453-4057qib7 5271 8 GVHD GVHD NNP cord-005453-4057qib7 5271 9 ) ) -RRB- cord-005453-4057qib7 5271 10 remains remain VBZ cord-005453-4057qib7 5271 11 a a DT cord-005453-4057qib7 5271 12 major major JJ cord-005453-4057qib7 5271 13 complication complication NN cord-005453-4057qib7 5271 14 of of IN cord-005453-4057qib7 5271 15 HSCT HSCT NNP cord-005453-4057qib7 5271 16 and and CC cord-005453-4057qib7 5271 17 leading leading JJ cord-005453-4057qib7 5271 18 cause cause NN cord-005453-4057qib7 5271 19 of of IN cord-005453-4057qib7 5271 20 morbidity morbidity NN cord-005453-4057qib7 5271 21 and and CC cord-005453-4057qib7 5271 22 mortality mortality NN cord-005453-4057qib7 5271 23 . . . cord-005453-4057qib7 5272 1 Prognosis prognosis NN cord-005453-4057qib7 5272 2 of of IN cord-005453-4057qib7 5272 3 patients patient NNS cord-005453-4057qib7 5272 4 with with IN cord-005453-4057qib7 5272 5 high high JJ cord-005453-4057qib7 5272 6 grade grade NN cord-005453-4057qib7 5272 7 GVHD GVHD NNP cord-005453-4057qib7 5272 8 is be VBZ cord-005453-4057qib7 5272 9 dismal dismal JJ cord-005453-4057qib7 5272 10 and and CC cord-005453-4057qib7 5272 11 survival survival NN cord-005453-4057qib7 5272 12 rate rate NN cord-005453-4057qib7 5272 13 varies vary VBZ cord-005453-4057qib7 5272 14 between between IN cord-005453-4057qib7 5272 15 25 25 CD cord-005453-4057qib7 5272 16 % % NN cord-005453-4057qib7 5272 17 to to IN cord-005453-4057qib7 5272 18 55 55 CD cord-005453-4057qib7 5272 19 % % NN cord-005453-4057qib7 5272 20 in in IN cord-005453-4057qib7 5272 21 pediatric pediatric JJ cord-005453-4057qib7 5272 22 patients patient NNS cord-005453-4057qib7 5272 23 . . . cord-005453-4057qib7 5273 1 Methods method NNS cord-005453-4057qib7 5273 2 : : : cord-005453-4057qib7 5274 1 The the DT cord-005453-4057qib7 5274 2 retrospective retrospective JJ cord-005453-4057qib7 5274 3 study study NN cord-005453-4057qib7 5274 4 included include VBD cord-005453-4057qib7 5274 5 patients patient NNS cord-005453-4057qib7 5274 6 with with IN cord-005453-4057qib7 5274 7 non non JJ cord-005453-4057qib7 5274 8 malignant malignant JJ cord-005453-4057qib7 5274 9 diseases disease NNS cord-005453-4057qib7 5274 10 who who WP cord-005453-4057qib7 5274 11 underwent undergo VBD cord-005453-4057qib7 5274 12 allogeneic allogeneic JJ cord-005453-4057qib7 5274 13 HSCT HSCT NNP cord-005453-4057qib7 5274 14 at at IN cord-005453-4057qib7 5274 15 Hadassah Hadassah NNP cord-005453-4057qib7 5274 16 Medical Medical NNP cord-005453-4057qib7 5274 17 Center Center NNP cord-005453-4057qib7 5274 18 from from IN cord-005453-4057qib7 5274 19 2008 2008 CD cord-005453-4057qib7 5274 20 to to IN cord-005453-4057qib7 5274 21 2018 2018 CD cord-005453-4057qib7 5274 22 . . . cord-005453-4057qib7 5275 1 The the DT cord-005453-4057qib7 5275 2 collected collect VBN cord-005453-4057qib7 5275 3 data datum NNS cord-005453-4057qib7 5275 4 included include VBD cord-005453-4057qib7 5275 5 patient´s patient´s NNP cord-005453-4057qib7 5275 6 clinical clinical JJ cord-005453-4057qib7 5275 7 data datum NNS cord-005453-4057qib7 5275 8 and and CC cord-005453-4057qib7 5275 9 transplant transplant NN cord-005453-4057qib7 5275 10 characteristics characteristic NNS cord-005453-4057qib7 5275 11 . . . cord-005453-4057qib7 5276 1 The the DT cord-005453-4057qib7 5276 2 study study NN cord-005453-4057qib7 5276 3 was be VBD cord-005453-4057qib7 5276 4 approved approve VBN cord-005453-4057qib7 5276 5 by by IN cord-005453-4057qib7 5276 6 the the DT cord-005453-4057qib7 5276 7 institutional institutional JJ cord-005453-4057qib7 5276 8 Helsinki Helsinki NNP cord-005453-4057qib7 5276 9 committee committee NN cord-005453-4057qib7 5276 10 . . . cord-005453-4057qib7 5277 1 Results result NNS cord-005453-4057qib7 5277 2 : : : cord-005453-4057qib7 5278 1 182 182 CD cord-005453-4057qib7 5278 2 children child NNS cord-005453-4057qib7 5278 3 with with IN cord-005453-4057qib7 5278 4 nonmalignant nonmalignant NNP cord-005453-4057qib7 5278 5 diseases disease NNS cord-005453-4057qib7 5278 6 underwent undergo VBD cord-005453-4057qib7 5278 7 194 194 CD cord-005453-4057qib7 5278 8 Allogeneic Allogeneic NNP cord-005453-4057qib7 5278 9 Bone Bone NNP cord-005453-4057qib7 5278 10 Marrow Marrow NNP cord-005453-4057qib7 5278 11 Transplantations Transplantations NNP cord-005453-4057qib7 5278 12 in in IN cord-005453-4057qib7 5278 13 Hadassah Hadassah NNP cord-005453-4057qib7 5278 14 University University NNP cord-005453-4057qib7 5278 15 Hospital Hospital NNP cord-005453-4057qib7 5278 16 during during IN cord-005453-4057qib7 5278 17 ten ten CD cord-005453-4057qib7 5278 18 years year NNS cord-005453-4057qib7 5278 19 period period NN cord-005453-4057qib7 5278 20 . . . cord-005453-4057qib7 5279 1 Fifty fifty CD cord-005453-4057qib7 5279 2 seven seven CD cord-005453-4057qib7 5279 3 patients patient NNS cord-005453-4057qib7 5279 4 ( ( -LRB- cord-005453-4057qib7 5279 5 31 31 CD cord-005453-4057qib7 5279 6 % % NN cord-005453-4057qib7 5279 7 ) ) -RRB- cord-005453-4057qib7 5279 8 developed develop VBD cord-005453-4057qib7 5279 9 AGVHD AGVHD NNP cord-005453-4057qib7 5279 10 grade grade NN cord-005453-4057qib7 5279 11 1 1 CD cord-005453-4057qib7 5279 12 - - SYM cord-005453-4057qib7 5279 13 4 4 CD cord-005453-4057qib7 5279 14 , , , cord-005453-4057qib7 5279 15 twenty twenty CD cord-005453-4057qib7 5279 16 five five CD cord-005453-4057qib7 5279 17 of of IN cord-005453-4057qib7 5279 18 them -PRON- PRP cord-005453-4057qib7 5279 19 ( ( -LRB- cord-005453-4057qib7 5279 20 13.7 13.7 CD cord-005453-4057qib7 5279 21 % % NN cord-005453-4057qib7 5279 22 ) ) -RRB- cord-005453-4057qib7 5279 23 grade grade NN cord-005453-4057qib7 5279 24 3 3 CD cord-005453-4057qib7 5279 25 - - SYM cord-005453-4057qib7 5279 26 4 4 CD cord-005453-4057qib7 5279 27 . . . cord-005453-4057qib7 5280 1 Median median JJ cord-005453-4057qib7 5280 2 age age NN cord-005453-4057qib7 5280 3 was be VBD cord-005453-4057qib7 5280 4 6.34 6.34 CD cord-005453-4057qib7 5281 1 ( ( -LRB- cord-005453-4057qib7 5281 2 range range NN cord-005453-4057qib7 5281 3 0.37 0.37 CD cord-005453-4057qib7 5281 4 - - SYM cord-005453-4057qib7 5281 5 17.7 17.7 CD cord-005453-4057qib7 5281 6 ) ) -RRB- cord-005453-4057qib7 5281 7 , , , cord-005453-4057qib7 5281 8 most most JJS cord-005453-4057qib7 5281 9 patients patient NNS cord-005453-4057qib7 5281 10 were be VBD cord-005453-4057qib7 5281 11 males male NNS cord-005453-4057qib7 5281 12 ( ( -LRB- cord-005453-4057qib7 5281 13 17 17 CD cord-005453-4057qib7 5281 14 males male NNS cord-005453-4057qib7 5281 15 , , , cord-005453-4057qib7 5281 16 8 8 CD cord-005453-4057qib7 5281 17 females female NNS cord-005453-4057qib7 5281 18 ) ) -RRB- cord-005453-4057qib7 5281 19 . . . cord-005453-4057qib7 5282 1 9 9 CD cord-005453-4057qib7 5282 2 patients patient NNS cord-005453-4057qib7 5282 3 underwent undergo VBD cord-005453-4057qib7 5282 4 BMT BMT NNP cord-005453-4057qib7 5282 5 from from IN cord-005453-4057qib7 5282 6 fully fully RB cord-005453-4057qib7 5282 7 matched match VBN cord-005453-4057qib7 5282 8 family family NN cord-005453-4057qib7 5282 9 members member NNS cord-005453-4057qib7 5282 10 , , , cord-005453-4057qib7 5282 11 6 6 CD cord-005453-4057qib7 5282 12 children child NNS cord-005453-4057qib7 5282 13 were be VBD cord-005453-4057qib7 5282 14 transplanted transplant VBN cord-005453-4057qib7 5282 15 from from IN cord-005453-4057qib7 5282 16 matched match VBN cord-005453-4057qib7 5282 17 unrelated unrelated JJ cord-005453-4057qib7 5282 18 donors donor NNS cord-005453-4057qib7 5282 19 and and CC cord-005453-4057qib7 5282 20 10 10 CD cord-005453-4057qib7 5282 21 from from IN cord-005453-4057qib7 5282 22 mismatched mismatched JJ cord-005453-4057qib7 5282 23 donors donor NNS cord-005453-4057qib7 5282 24 . . . cord-005453-4057qib7 5283 1 Twenty twenty CD cord-005453-4057qib7 5283 2 one one CD cord-005453-4057qib7 5283 3 of of IN cord-005453-4057qib7 5283 4 25 25 CD cord-005453-4057qib7 5283 5 patients patient NNS cord-005453-4057qib7 5283 6 with with IN cord-005453-4057qib7 5283 7 severe severe JJ cord-005453-4057qib7 5283 8 GVHD GVHD NNP cord-005453-4057qib7 5283 9 ( ( -LRB- cord-005453-4057qib7 5283 10 83 83 CD cord-005453-4057qib7 5283 11 % % NN cord-005453-4057qib7 5283 12 ) ) -RRB- cord-005453-4057qib7 5283 13 survived survive VBD cord-005453-4057qib7 5283 14 . . . cord-005453-4057qib7 5284 1 Four four CD cord-005453-4057qib7 5284 2 patients patient NNS cord-005453-4057qib7 5284 3 ( ( -LRB- cord-005453-4057qib7 5284 4 17 17 CD cord-005453-4057qib7 5284 5 % % NN cord-005453-4057qib7 5284 6 ) ) -RRB- cord-005453-4057qib7 5284 7 died die VBD cord-005453-4057qib7 5284 8 from from IN cord-005453-4057qib7 5284 9 severe severe JJ cord-005453-4057qib7 5284 10 GVHD GVHD NNP cord-005453-4057qib7 5284 11 and and CC cord-005453-4057qib7 5284 12 complications complication NNS cord-005453-4057qib7 5284 13 of of IN cord-005453-4057qib7 5284 14 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 5284 15 treatment treatment NN cord-005453-4057qib7 5284 16 . . . cord-005453-4057qib7 5285 1 3 3 CD cord-005453-4057qib7 5285 2 of of IN cord-005453-4057qib7 5285 3 4 4 CD cord-005453-4057qib7 5285 4 deceased deceased JJ cord-005453-4057qib7 5285 5 patients patient NNS cord-005453-4057qib7 5285 6 were be VBD cord-005453-4057qib7 5285 7 transplanted transplant VBN cord-005453-4057qib7 5285 8 from from IN cord-005453-4057qib7 5285 9 mismatched mismatched JJ cord-005453-4057qib7 5285 10 donor donor NN cord-005453-4057qib7 5285 11 , , , cord-005453-4057qib7 5285 12 in in IN cord-005453-4057qib7 5285 13 3 3 CD cord-005453-4057qib7 5285 14 of of IN cord-005453-4057qib7 5285 15 4 4 CD cord-005453-4057qib7 5285 16 cases case NNS cord-005453-4057qib7 5285 17 the the DT cord-005453-4057qib7 5285 18 age age NN cord-005453-4057qib7 5285 19 of of IN cord-005453-4057qib7 5285 20 donor donor NN cord-005453-4057qib7 5285 21 was be VBD cord-005453-4057qib7 5285 22 advanced advanced JJ cord-005453-4057qib7 5285 23 , , , cord-005453-4057qib7 5285 24 2 2 CD cord-005453-4057qib7 5285 25 of of IN cord-005453-4057qib7 5285 26 4 4 CD cord-005453-4057qib7 5285 27 patients patient NNS cord-005453-4057qib7 5285 28 developed develop VBD cord-005453-4057qib7 5285 29 severe severe JJ cord-005453-4057qib7 5285 30 GVHD GVHD NNP cord-005453-4057qib7 5285 31 and and CC cord-005453-4057qib7 5285 32 died die VBD cord-005453-4057qib7 5285 33 after after IN cord-005453-4057qib7 5285 34 second second JJ cord-005453-4057qib7 5285 35 HSCT HSCT NNP cord-005453-4057qib7 5285 36 . . . cord-005453-4057qib7 5286 1 All all DT cord-005453-4057qib7 5286 2 4 4 CD cord-005453-4057qib7 5286 3 patients patient NNS cord-005453-4057qib7 5286 4 were be VBD cord-005453-4057qib7 5286 5 refractory refractory JJ cord-005453-4057qib7 5286 6 to to IN cord-005453-4057qib7 5286 7 different different JJ cord-005453-4057qib7 5286 8 treatment treatment NN cord-005453-4057qib7 5286 9 modalities modality NNS cord-005453-4057qib7 5286 10 . . . cord-005453-4057qib7 5287 1 Three three CD cord-005453-4057qib7 5287 2 of of IN cord-005453-4057qib7 5287 3 4 4 CD cord-005453-4057qib7 5287 4 patients patient NNS cord-005453-4057qib7 5287 5 died die VBD cord-005453-4057qib7 5287 6 in in IN cord-005453-4057qib7 5287 7 2012 2012 CD cord-005453-4057qib7 5287 8 and and CC cord-005453-4057qib7 5287 9 one one CD cord-005453-4057qib7 5287 10 in in IN cord-005453-4057qib7 5287 11 2015 2015 CD cord-005453-4057qib7 5287 12 , , , cord-005453-4057qib7 5287 13 it -PRON- PRP cord-005453-4057qib7 5287 14 was be VBD cord-005453-4057qib7 5287 15 no no DT cord-005453-4057qib7 5287 16 death death NN cord-005453-4057qib7 5287 17 from from IN cord-005453-4057qib7 5287 18 severe severe JJ cord-005453-4057qib7 5287 19 GVHD GVHD NNP cord-005453-4057qib7 5287 20 in in IN cord-005453-4057qib7 5287 21 12 12 CD cord-005453-4057qib7 5287 22 patients patient NNS cord-005453-4057qib7 5287 23 that that WDT cord-005453-4057qib7 5287 24 were be VBD cord-005453-4057qib7 5287 25 transplanted transplant VBN cord-005453-4057qib7 5287 26 and and CC cord-005453-4057qib7 5287 27 developed develop VBN cord-005453-4057qib7 5287 28 high high JJ cord-005453-4057qib7 5287 29 grade grade NN cord-005453-4057qib7 5287 30 GVHD GVHD NNP cord-005453-4057qib7 5287 31 after after IN cord-005453-4057qib7 5287 32 2015 2015 CD cord-005453-4057qib7 5287 33 . . . cord-005453-4057qib7 5288 1 Conclusions conclusion NNS cord-005453-4057qib7 5288 2 : : : cord-005453-4057qib7 5289 1 The the DT cord-005453-4057qib7 5289 2 results result NNS cord-005453-4057qib7 5289 3 of of IN cord-005453-4057qib7 5289 4 this this DT cord-005453-4057qib7 5289 5 study study NN cord-005453-4057qib7 5289 6 show show VBP cord-005453-4057qib7 5289 7 a a DT cord-005453-4057qib7 5289 8 high high JJ cord-005453-4057qib7 5289 9 survival survival NN cord-005453-4057qib7 5289 10 rate rate NN cord-005453-4057qib7 5289 11 of of IN cord-005453-4057qib7 5289 12 83 83 CD cord-005453-4057qib7 5289 13 % % NN cord-005453-4057qib7 5289 14 in in IN cord-005453-4057qib7 5289 15 pediatric pediatric JJ cord-005453-4057qib7 5289 16 patients patient NNS cord-005453-4057qib7 5289 17 with with IN cord-005453-4057qib7 5289 18 non non JJ cord-005453-4057qib7 5289 19 malignant malignant JJ cord-005453-4057qib7 5289 20 diseases disease NNS cord-005453-4057qib7 5289 21 and and CC cord-005453-4057qib7 5289 22 severe severe JJ cord-005453-4057qib7 5289 23 GVHD GVHD NNP cord-005453-4057qib7 5289 24 . . . cord-005453-4057qib7 5290 1 Significant significant JJ cord-005453-4057qib7 5290 2 risk risk NN cord-005453-4057qib7 5290 3 factors factor NNS cord-005453-4057qib7 5290 4 for for IN cord-005453-4057qib7 5290 5 mortality mortality NN cord-005453-4057qib7 5290 6 in in IN cord-005453-4057qib7 5290 7 our -PRON- PRP$ cord-005453-4057qib7 5290 8 group group NN cord-005453-4057qib7 5290 9 included include VBD cord-005453-4057qib7 5290 10 mismatched mismatched JJ cord-005453-4057qib7 5290 11 donor donor NN cord-005453-4057qib7 5290 12 , , , cord-005453-4057qib7 5290 13 advanced advanced JJ cord-005453-4057qib7 5290 14 age age NN cord-005453-4057qib7 5290 15 of of IN cord-005453-4057qib7 5290 16 donor donor NN cord-005453-4057qib7 5290 17 and and CC cord-005453-4057qib7 5290 18 second second JJ cord-005453-4057qib7 5290 19 transplant transplant NN cord-005453-4057qib7 5290 20 . . . cord-005453-4057qib7 5291 1 Trend trend NN cord-005453-4057qib7 5291 2 to to IN cord-005453-4057qib7 5291 3 better well JJR cord-005453-4057qib7 5291 4 survival survival NN cord-005453-4057qib7 5291 5 was be VBD cord-005453-4057qib7 5291 6 observed observe VBN cord-005453-4057qib7 5291 7 after after IN cord-005453-4057qib7 5291 8 2015 2015 CD cord-005453-4057qib7 5291 9 . . . cord-005453-4057qib7 5292 1 Additional additional JJ cord-005453-4057qib7 5292 2 multicentral multicentral JJ cord-005453-4057qib7 5292 3 studies study NNS cord-005453-4057qib7 5292 4 analyzed analyze VBD cord-005453-4057qib7 5292 5 the the DT cord-005453-4057qib7 5292 6 outcomes outcome NNS cord-005453-4057qib7 5292 7 of of IN cord-005453-4057qib7 5292 8 aGVHD aGVHD NNP cord-005453-4057qib7 5292 9 in in IN cord-005453-4057qib7 5292 10 pediatric pediatric JJ cord-005453-4057qib7 5292 11 patients patient NNS cord-005453-4057qib7 5292 12 with with IN cord-005453-4057qib7 5292 13 nonmalignant nonmalignant JJ cord-005453-4057qib7 5292 14 diseases disease NNS cord-005453-4057qib7 5292 15 are be VBP cord-005453-4057qib7 5292 16 urgently urgently RB cord-005453-4057qib7 5292 17 required require VBN cord-005453-4057qib7 5292 18 . . . cord-005453-4057qib7 5293 1 Background background NN cord-005453-4057qib7 5293 2 : : : cord-005453-4057qib7 5294 1 Chronic Chronic NNP cord-005453-4057qib7 5294 2 Graft graft NN cord-005453-4057qib7 5294 3 - - HYPH cord-005453-4057qib7 5294 4 versus versus IN cord-005453-4057qib7 5294 5 - - HYPH cord-005453-4057qib7 5294 6 Host host NN cord-005453-4057qib7 5294 7 Disease Disease NNP cord-005453-4057qib7 5294 8 ( ( -LRB- cord-005453-4057qib7 5294 9 cGvHD cGvHD NNP cord-005453-4057qib7 5294 10 ) ) -RRB- cord-005453-4057qib7 5294 11 is be VBZ cord-005453-4057qib7 5294 12 a a DT cord-005453-4057qib7 5294 13 serious serious JJ cord-005453-4057qib7 5294 14 late late JJ cord-005453-4057qib7 5294 15 complication complication NN cord-005453-4057qib7 5294 16 after after IN cord-005453-4057qib7 5294 17 allogeneic allogeneic JJ cord-005453-4057qib7 5294 18 hematopoietic hematopoietic JJ cord-005453-4057qib7 5294 19 stem stem NN cord-005453-4057qib7 5294 20 cell cell NN cord-005453-4057qib7 5294 21 transplantation transplantation NN cord-005453-4057qib7 5294 22 ( ( -LRB- cord-005453-4057qib7 5294 23 alloHSCT alloHSCT NNP cord-005453-4057qib7 5294 24 ) ) -RRB- cord-005453-4057qib7 5294 25 with with IN cord-005453-4057qib7 5294 26 heterogeneous heterogeneous JJ cord-005453-4057qib7 5294 27 presentation presentation NN cord-005453-4057qib7 5294 28 and and CC cord-005453-4057qib7 5294 29 still still RB cord-005453-4057qib7 5294 30 poorly poorly RB cord-005453-4057qib7 5294 31 understood understand VBD cord-005453-4057qib7 5294 32 pathophysiology pathophysiology NN cord-005453-4057qib7 5294 33 including include VBG cord-005453-4057qib7 5294 34 inflammation inflammation NN cord-005453-4057qib7 5294 35 and and CC cord-005453-4057qib7 5294 36 endothelial endothelial JJ cord-005453-4057qib7 5294 37 dysfunction dysfunction NN cord-005453-4057qib7 5294 38 . . . cord-005453-4057qib7 5295 1 Factor factor NN cord-005453-4057qib7 5295 2 VIII VIII NNP cord-005453-4057qib7 5295 3 ( ( -LRB- cord-005453-4057qib7 5295 4 FVIII FVIII NNP cord-005453-4057qib7 5295 5 ) ) -RRB- cord-005453-4057qib7 5295 6 and and CC cord-005453-4057qib7 5295 7 von von NNP cord-005453-4057qib7 5295 8 Willebrand Willebrand NNP cord-005453-4057qib7 5295 9 Factor Factor NNP cord-005453-4057qib7 5295 10 ( ( -LRB- cord-005453-4057qib7 5295 11 VWF VWF NNP cord-005453-4057qib7 5295 12 ) ) -RRB- cord-005453-4057qib7 5295 13 are be VBP cord-005453-4057qib7 5295 14 coagulation coagulation NN cord-005453-4057qib7 5295 15 factors factor NNS cord-005453-4057qib7 5295 16 but but CC cord-005453-4057qib7 5295 17 also also RB cord-005453-4057qib7 5295 18 known know VBN cord-005453-4057qib7 5295 19 indicators indicator NNS cord-005453-4057qib7 5295 20 of of IN cord-005453-4057qib7 5295 21 endothelial endothelial JJ cord-005453-4057qib7 5295 22 dysfunction dysfunction NN cord-005453-4057qib7 5295 23 and and CC cord-005453-4057qib7 5295 24 inflammation inflammation NN cord-005453-4057qib7 5295 25 in in IN cord-005453-4057qib7 5295 26 different different JJ cord-005453-4057qib7 5295 27 settings setting NNS cord-005453-4057qib7 5295 28 , , , cord-005453-4057qib7 5295 29 and and CC cord-005453-4057qib7 5295 30 therefore therefore RB cord-005453-4057qib7 5295 31 could could MD cord-005453-4057qib7 5295 32 serve serve VB cord-005453-4057qib7 5295 33 as as RB cord-005453-4057qib7 5295 34 interesting interesting JJ cord-005453-4057qib7 5295 35 candidate candidate NN cord-005453-4057qib7 5295 36 biomarkers biomarker NNS cord-005453-4057qib7 5295 37 of of IN cord-005453-4057qib7 5295 38 cGvHD cgvhd NN cord-005453-4057qib7 5295 39 . . . cord-005453-4057qib7 5296 1 Methods method NNS cord-005453-4057qib7 5296 2 : : : cord-005453-4057qib7 5296 3 Since since IN cord-005453-4057qib7 5296 4 2013 2013 CD cord-005453-4057qib7 5296 5 patients patient NNS cord-005453-4057qib7 5296 6 after after IN cord-005453-4057qib7 5296 7 alloHSCT alloHSCT NNP cord-005453-4057qib7 5296 8 were be VBD cord-005453-4057qib7 5296 9 assessed assess VBN cord-005453-4057qib7 5296 10 by by IN cord-005453-4057qib7 5296 11 the the DT cord-005453-4057qib7 5296 12 Multidisciplinary Multidisciplinary NNP cord-005453-4057qib7 5296 13 cGvHD cgvhd NN cord-005453-4057qib7 5296 14 team team NN cord-005453-4057qib7 5296 15 at at IN cord-005453-4057qib7 5296 16 the the DT cord-005453-4057qib7 5296 17 University University NNP cord-005453-4057qib7 5296 18 Hospital Hospital NNP cord-005453-4057qib7 5296 19 Center Center NNP cord-005453-4057qib7 5296 20 Zagreb Zagreb NNP cord-005453-4057qib7 5296 21 , , , cord-005453-4057qib7 5296 22 Croatia Croatia NNP cord-005453-4057qib7 5296 23 , , , cord-005453-4057qib7 5296 24 using use VBG cord-005453-4057qib7 5296 25 established establish VBN cord-005453-4057qib7 5296 26 NIH NIH NNP cord-005453-4057qib7 5296 27 cGvHD cgvhd RB cord-005453-4057qib7 5296 28 - - HYPH cord-005453-4057qib7 5296 29 related relate VBN cord-005453-4057qib7 5296 30 measurements measurement NNS cord-005453-4057qib7 5296 31 . . . cord-005453-4057qib7 5297 1 An an DT cord-005453-4057qib7 5297 2 extensive extensive JJ cord-005453-4057qib7 5297 3 history history NN cord-005453-4057qib7 5297 4 , , , cord-005453-4057qib7 5297 5 physical physical JJ cord-005453-4057qib7 5297 6 and and CC cord-005453-4057qib7 5297 7 laboratory laboratory NN cord-005453-4057qib7 5297 8 evaluations evaluation NNS cord-005453-4057qib7 5297 9 were be VBD cord-005453-4057qib7 5297 10 performed perform VBN cord-005453-4057qib7 5297 11 , , , cord-005453-4057qib7 5297 12 including include VBG cord-005453-4057qib7 5297 13 FVIII FVIII NNP cord-005453-4057qib7 5297 14 , , , cord-005453-4057qib7 5297 15 VWF VWF NNP cord-005453-4057qib7 5297 16 : : : cord-005453-4057qib7 5298 1 Ag Ag NNP cord-005453-4057qib7 5298 2 and and CC cord-005453-4057qib7 5298 3 VWF VWF NNP cord-005453-4057qib7 5298 4 : : : cord-005453-4057qib7 5299 1 Ac Ac NNP cord-005453-4057qib7 5299 2 analysis analysis NN cord-005453-4057qib7 5299 3 . . . cord-005453-4057qib7 5300 1 Descriptive descriptive JJ cord-005453-4057qib7 5300 2 statistic statistic NN cord-005453-4057qib7 5300 3 and and CC cord-005453-4057qib7 5300 4 non non JJ cord-005453-4057qib7 5300 5 - - JJ cord-005453-4057qib7 5300 6 parametric parametric JJ cord-005453-4057qib7 5300 7 analyses analysis NNS cord-005453-4057qib7 5300 8 were be VBD cord-005453-4057qib7 5300 9 performed perform VBN cord-005453-4057qib7 5300 10 . . . cord-005453-4057qib7 5301 1 Variables variable NNS cord-005453-4057qib7 5301 2 that that WDT cord-005453-4057qib7 5301 3 showed show VBD cord-005453-4057qib7 5301 4 significant significant JJ cord-005453-4057qib7 5301 5 univariate univariate JJ cord-005453-4057qib7 5301 6 correlations correlation NNS cord-005453-4057qib7 5301 7 were be VBD cord-005453-4057qib7 5301 8 used use VBN cord-005453-4057qib7 5301 9 in in IN cord-005453-4057qib7 5301 10 multivariate multivariate JJ cord-005453-4057qib7 5301 11 logistic logistic JJ cord-005453-4057qib7 5301 12 regression regression NN cord-005453-4057qib7 5301 13 ( ( -LRB- cord-005453-4057qib7 5301 14 MLR MLR NNP cord-005453-4057qib7 5301 15 ) ) -RRB- cord-005453-4057qib7 5301 16 to to TO cord-005453-4057qib7 5301 17 identify identify VB cord-005453-4057qib7 5301 18 the the DT cord-005453-4057qib7 5301 19 most most RBS cord-005453-4057qib7 5301 20 predictive predictive JJ cord-005453-4057qib7 5301 21 for for IN cord-005453-4057qib7 5301 22 FVIII FVIII NNP cord-005453-4057qib7 5301 23 , , , cord-005453-4057qib7 5301 24 VWF VWF NNP cord-005453-4057qib7 5301 25 : : : cord-005453-4057qib7 5302 1 Ag Ag NNP cord-005453-4057qib7 5302 2 and and CC cord-005453-4057qib7 5302 3 VWF VWF NNP cord-005453-4057qib7 5302 4 : : : cord-005453-4057qib7 5303 1 Ac Ac NNP cord-005453-4057qib7 5303 2 in in IN cord-005453-4057qib7 5303 3 cGvHD cgvhd NN cord-005453-4057qib7 5303 4 patients patient NNS cord-005453-4057qib7 5303 5 . . . cord-005453-4057qib7 5304 1 Results result NNS cord-005453-4057qib7 5304 2 : : : cord-005453-4057qib7 5304 3 70 70 CD cord-005453-4057qib7 5304 4 cGvHD cgvhd NN cord-005453-4057qib7 5304 5 patients patient NNS cord-005453-4057qib7 5304 6 and and CC cord-005453-4057qib7 5304 7 41 41 CD cord-005453-4057qib7 5304 8 controls control NNS cord-005453-4057qib7 5304 9 ( ( -LRB- cord-005453-4057qib7 5304 10 subjects subject NNS cord-005453-4057qib7 5304 11 after after IN cord-005453-4057qib7 5304 12 alloHSCT alloHSCT NNP cord-005453-4057qib7 5304 13 without without IN cord-005453-4057qib7 5304 14 cGvHD cGvHD NNP cord-005453-4057qib7 5304 15 ) ) -RRB- cord-005453-4057qib7 5304 16 were be VBD cord-005453-4057qib7 5304 17 analysed analyse VBN cord-005453-4057qib7 5304 18 . . . cord-005453-4057qib7 5305 1 Median median JJ cord-005453-4057qib7 5305 2 age age NN cord-005453-4057qib7 5305 3 of of IN cord-005453-4057qib7 5305 4 cGvHD cgvhd NN cord-005453-4057qib7 5305 5 patients patient NNS cord-005453-4057qib7 5305 6 was be VBD cord-005453-4057qib7 5305 7 42 42 CD cord-005453-4057qib7 5305 8 ( ( -LRB- cord-005453-4057qib7 5305 9 9 9 CD cord-005453-4057qib7 5305 10 - - SYM cord-005453-4057qib7 5305 11 65 65 CD cord-005453-4057qib7 5305 12 ) ) -RRB- cord-005453-4057qib7 5305 13 years year NNS cord-005453-4057qib7 5305 14 , , , cord-005453-4057qib7 5305 15 50 50 CD cord-005453-4057qib7 5305 16 % % NN cord-005453-4057qib7 5305 17 females female NNS cord-005453-4057qib7 5305 18 , , , cord-005453-4057qib7 5305 19 91.5 91.5 CD cord-005453-4057qib7 5305 20 % % NN cord-005453-4057qib7 5305 21 underwent undergo VBD cord-005453-4057qib7 5305 22 alloHSCT alloHSCT NNP cord-005453-4057qib7 5305 23 for for IN cord-005453-4057qib7 5305 24 hematologic hematologic JJ cord-005453-4057qib7 5305 25 malignancies malignancy NNS cord-005453-4057qib7 5305 26 , , , cord-005453-4057qib7 5305 27 55.7 55.7 CD cord-005453-4057qib7 5305 28 % % NN cord-005453-4057qib7 5305 29 had have VBD cord-005453-4057qib7 5305 30 myeloablative myeloablative JJ cord-005453-4057qib7 5305 31 conditioning conditioning NN cord-005453-4057qib7 5305 32 and and CC cord-005453-4057qib7 5305 33 52.9 52.9 CD cord-005453-4057qib7 5305 34 % % NN cord-005453-4057qib7 5305 35 matched match VBN cord-005453-4057qib7 5305 36 related related JJ cord-005453-4057qib7 5305 37 donor donor NN cord-005453-4057qib7 5305 38 . . . cord-005453-4057qib7 5306 1 Median median JJ cord-005453-4057qib7 5306 2 time time NN cord-005453-4057qib7 5306 3 from from IN cord-005453-4057qib7 5306 4 HSCT HSCT NNP cord-005453-4057qib7 5306 5 to to TO cord-005453-4057qib7 5306 6 study study VB cord-005453-4057qib7 5306 7 was be VBD cord-005453-4057qib7 5306 8 450.5 450.5 CD cord-005453-4057qib7 5306 9 days day NNS cord-005453-4057qib7 5306 10 and and CC cord-005453-4057qib7 5306 11 from from IN cord-005453-4057qib7 5306 12 cGvHD cGvHD NNP cord-005453-4057qib7 5306 13 diagnosis diagnosis NN cord-005453-4057qib7 5306 14 to to TO cord-005453-4057qib7 5306 15 study study VB cord-005453-4057qib7 5306 16 82 82 CD cord-005453-4057qib7 5306 17 days day NNS cord-005453-4057qib7 5306 18 . . . cord-005453-4057qib7 5307 1 There there EX cord-005453-4057qib7 5307 2 were be VBD cord-005453-4057qib7 5307 3 no no DT cord-005453-4057qib7 5307 4 demographic demographic JJ cord-005453-4057qib7 5308 1 neither neither DT cord-005453-4057qib7 5308 2 transplant transplant NN cord-005453-4057qib7 5308 3 related relate VBD cord-005453-4057qib7 5308 4 significant significant JJ cord-005453-4057qib7 5308 5 differences difference NNS cord-005453-4057qib7 5308 6 between between IN cord-005453-4057qib7 5308 7 cGvHD cgvhd NN cord-005453-4057qib7 5308 8 patients patient NNS cord-005453-4057qib7 5308 9 and and CC cord-005453-4057qib7 5308 10 controls control NNS cord-005453-4057qib7 5308 11 beside beside IN cord-005453-4057qib7 5308 12 stem stem NN cord-005453-4057qib7 5308 13 cell cell NN cord-005453-4057qib7 5308 14 source source NN cord-005453-4057qib7 5308 15 ( ( -LRB- cord-005453-4057qib7 5308 16 peripheral peripheral JJ cord-005453-4057qib7 5308 17 blood blood NN cord-005453-4057qib7 5308 18 71.4 71.4 CD cord-005453-4057qib7 5308 19 % % NN cord-005453-4057qib7 5308 20 vs vs IN cord-005453-4057qib7 5308 21 51.2 51.2 CD cord-005453-4057qib7 5308 22 % % NN cord-005453-4057qib7 5308 23 , , , cord-005453-4057qib7 5308 24 p=0.041 p=0.041 NNP cord-005453-4057qib7 5308 25 ) ) -RRB- cord-005453-4057qib7 5308 26 and and CC cord-005453-4057qib7 5308 27 history history NN cord-005453-4057qib7 5308 28 of of IN cord-005453-4057qib7 5308 29 acute acute JJ cord-005453-4057qib7 5308 30 GvHD GvHD NNP cord-005453-4057qib7 5308 31 ( ( -LRB- cord-005453-4057qib7 5308 32 70.0 70.0 CD cord-005453-4057qib7 5308 33 % % NN cord-005453-4057qib7 5308 34 vs vs IN cord-005453-4057qib7 5308 35 22.0 22.0 CD cord-005453-4057qib7 5308 36 % % NN cord-005453-4057qib7 5308 37 , , , cord-005453-4057qib7 5308 38 p p NN cord-005453-4057qib7 5308 39 < < XX cord-005453-4057qib7 5308 40 0.001 0.001 CD cord-005453-4057qib7 5308 41 ) ) -RRB- cord-005453-4057qib7 5308 42 . . . cord-005453-4057qib7 5309 1 Majority majority NN cord-005453-4057qib7 5309 2 of of IN cord-005453-4057qib7 5309 3 patients patient NNS cord-005453-4057qib7 5309 4 had have VBD cord-005453-4057qib7 5309 5 moderate moderate JJ cord-005453-4057qib7 5309 6 ( ( -LRB- cord-005453-4057qib7 5309 7 52.9 52.9 CD cord-005453-4057qib7 5309 8 % % NN cord-005453-4057qib7 5309 9 ) ) -RRB- cord-005453-4057qib7 5309 10 or or CC cord-005453-4057qib7 5309 11 severe severe JJ cord-005453-4057qib7 5309 12 ( ( -LRB- cord-005453-4057qib7 5309 13 42.6 42.6 CD cord-005453-4057qib7 5309 14 % % NN cord-005453-4057qib7 5309 15 ) ) -RRB- cord-005453-4057qib7 5310 1 NIH NIH NNP cord-005453-4057qib7 5310 2 global global JJ cord-005453-4057qib7 5310 3 cGvHD cGvHD NNP cord-005453-4057qib7 5310 4 score score NN cord-005453-4057qib7 5310 5 , , , cord-005453-4057qib7 5310 6 57.2 57.2 CD cord-005453-4057qib7 5310 7 % % NN cord-005453-4057qib7 5310 8 active active JJ cord-005453-4057qib7 5310 9 cGvHD cgvhd NN cord-005453-4057qib7 5310 10 by by IN cord-005453-4057qib7 5310 11 clinician´s clinician´s NNP cord-005453-4057qib7 5310 12 impression impression NN cord-005453-4057qib7 5310 13 . . . cord-005453-4057qib7 5311 1 Median median JJ cord-005453-4057qib7 5311 2 number number NN cord-005453-4057qib7 5311 3 of of IN cord-005453-4057qib7 5311 4 organs organ NNS cord-005453-4057qib7 5311 5 involved involve VBN cord-005453-4057qib7 5311 6 by by IN cord-005453-4057qib7 5311 7 cGvHD cGvHD NNP cord-005453-4057qib7 5311 8 was be VBD cord-005453-4057qib7 5311 9 3 3 CD cord-005453-4057qib7 5311 10 ( ( -LRB- cord-005453-4057qib7 5311 11 1 1 CD cord-005453-4057qib7 5311 12 - - SYM cord-005453-4057qib7 5311 13 6 6 CD cord-005453-4057qib7 5311 14 ) ) -RRB- cord-005453-4057qib7 5311 15 , , , cord-005453-4057qib7 5311 16 and and CC cord-005453-4057qib7 5311 17 the the DT cord-005453-4057qib7 5311 18 most most RBS cord-005453-4057qib7 5311 19 frequently frequently RB cord-005453-4057qib7 5311 20 involved involve VBN cord-005453-4057qib7 5311 21 organs organ NNS cord-005453-4057qib7 5311 22 were be VBD cord-005453-4057qib7 5311 23 mouth mouth NN cord-005453-4057qib7 5311 24 , , , cord-005453-4057qib7 5311 25 skin skin NN cord-005453-4057qib7 5311 26 and and CC cord-005453-4057qib7 5311 27 eyes eye NNS cord-005453-4057qib7 5311 28 ( ( -LRB- cord-005453-4057qib7 5311 29 52.0 52.0 CD cord-005453-4057qib7 5311 30 % % NN cord-005453-4057qib7 5311 31 each each DT cord-005453-4057qib7 5311 32 ) ) -RRB- cord-005453-4057qib7 5311 33 . . . cord-005453-4057qib7 5312 1 cGvHD cGvHD NNP cord-005453-4057qib7 5312 2 patients patient NNS cord-005453-4057qib7 5312 3 compared compare VBN cord-005453-4057qib7 5312 4 to to IN cord-005453-4057qib7 5312 5 controls control NNS cord-005453-4057qib7 5312 6 had have VBD cord-005453-4057qib7 5312 7 higher high JJR cord-005453-4057qib7 5312 8 FVIII FVIII NNP cord-005453-4057qib7 5312 9 levels level NNS cord-005453-4057qib7 5312 10 ( ( -LRB- cord-005453-4057qib7 5312 11 median median JJ cord-005453-4057qib7 5312 12 206 206 CD cord-005453-4057qib7 5312 13 ( ( -LRB- cord-005453-4057qib7 5312 14 52 52 CD cord-005453-4057qib7 5312 15 - - SYM cord-005453-4057qib7 5312 16 453)% 453)% CD cord-005453-4057qib7 5312 17 vs vs IN cord-005453-4057qib7 5312 18 182 182 CD cord-005453-4057qib7 5312 19 ( ( -LRB- cord-005453-4057qib7 5312 20 51 51 CD cord-005453-4057qib7 5312 21 - - SYM cord-005453-4057qib7 5312 22 406)% 406)% CD cord-005453-4057qib7 5312 23 , , , cord-005453-4057qib7 5312 24 p=0.044 p=0.044 NNS cord-005453-4057qib7 5313 1 , , , cord-005453-4057qib7 5313 2 reference reference NN cord-005453-4057qib7 5313 3 range range NN cord-005453-4057qib7 5313 4 50 50 CD cord-005453-4057qib7 5313 5 - - SYM cord-005453-4057qib7 5313 6 149 149 CD cord-005453-4057qib7 5313 7 % % NN cord-005453-4057qib7 5313 8 ) ) -RRB- cord-005453-4057qib7 5313 9 and and CC cord-005453-4057qib7 5313 10 higher high JJR cord-005453-4057qib7 5313 11 VWF VWF NNP cord-005453-4057qib7 5313 12 : : : cord-005453-4057qib7 5314 1 Ag Ag NNP cord-005453-4057qib7 5314 2 ( ( -LRB- cord-005453-4057qib7 5314 3 median median JJ cord-005453-4057qib7 5314 4 261.6 261.6 CD cord-005453-4057qib7 5314 5 ( ( -LRB- cord-005453-4057qib7 5314 6 76.6 76.6 CD cord-005453-4057qib7 5314 7 - - HYPH cord-005453-4057qib7 5314 8 601)% 601)% CD cord-005453-4057qib7 5315 1 vs vs IN cord-005453-4057qib7 5315 2 203.2 203.2 CD cord-005453-4057qib7 5315 3 ( ( -LRB- cord-005453-4057qib7 5315 4 51.9 51.9 CD cord-005453-4057qib7 5315 5 - - SYM cord-005453-4057qib7 5315 6 600)% 600)% CD cord-005453-4057qib7 5315 7 , , , cord-005453-4057qib7 5315 8 p=0.030 p=0.030 NNP cord-005453-4057qib7 5315 9 , , , cord-005453-4057qib7 5315 10 reference reference NN cord-005453-4057qib7 5315 11 range range NN cord-005453-4057qib7 5315 12 50 50 CD cord-005453-4057qib7 5315 13 - - SYM cord-005453-4057qib7 5315 14 160 160 CD cord-005453-4057qib7 5315 15 % % NN cord-005453-4057qib7 5315 16 ) ) -RRB- cord-005453-4057qib7 5315 17 , , , cord-005453-4057qib7 5315 18 while while IN cord-005453-4057qib7 5315 19 VWF VWF NNP cord-005453-4057qib7 5315 20 : : : cord-005453-4057qib7 5316 1 Ac Ac NNP cord-005453-4057qib7 5316 2 showed show VBD cord-005453-4057qib7 5316 3 a a DT cord-005453-4057qib7 5316 4 trend trend NN cord-005453-4057qib7 5316 5 toward toward IN cord-005453-4057qib7 5316 6 higher high JJR cord-005453-4057qib7 5316 7 levels level NNS cord-005453-4057qib7 5316 8 among among IN cord-005453-4057qib7 5316 9 patients patient NNS cord-005453-4057qib7 5316 10 ( ( -LRB- cord-005453-4057qib7 5316 11 median median JJ cord-005453-4057qib7 5316 12 253.4 253.4 CD cord-005453-4057qib7 5316 13 ( ( -LRB- cord-005453-4057qib7 5316 14 54 54 CD cord-005453-4057qib7 5316 15 - - SYM cord-005453-4057qib7 5316 16 601)% 601)% CD cord-005453-4057qib7 5316 17 vs vs IN cord-005453-4057qib7 5316 18 178 178 CD cord-005453-4057qib7 5316 19 ( ( -LRB- cord-005453-4057qib7 5316 20 48.6 48.6 CD cord-005453-4057qib7 5316 21 - - SYM cord-005453-4057qib7 5316 22 601)% 601)% CD cord-005453-4057qib7 5316 23 , , , cord-005453-4057qib7 5316 24 p=0.084 p=0.084 NNP cord-005453-4057qib7 5317 1 , , , cord-005453-4057qib7 5317 2 reference reference NN cord-005453-4057qib7 5317 3 range range NN cord-005453-4057qib7 5317 4 50 50 CD cord-005453-4057qib7 5317 5 - - SYM cord-005453-4057qib7 5317 6 150 150 CD cord-005453-4057qib7 5317 7 % % NN cord-005453-4057qib7 5317 8 ) ) -RRB- cord-005453-4057qib7 5317 9 . . . cord-005453-4057qib7 5318 1 Patients patient NNS cord-005453-4057qib7 5318 2 had have VBD cord-005453-4057qib7 5318 3 higher high JJR cord-005453-4057qib7 5318 4 GGT ggt NN cord-005453-4057qib7 5318 5 ( ( -LRB- cord-005453-4057qib7 5318 6 p=0.002 p=0.002 NNP cord-005453-4057qib7 5318 7 ) ) -RRB- cord-005453-4057qib7 5318 8 , , , cord-005453-4057qib7 5318 9 lower lower VB cord-005453-4057qib7 5318 10 anticardiolipin anticardiolipin NNP cord-005453-4057qib7 5318 11 IgG IgG NNP cord-005453-4057qib7 5318 12 ( ( -LRB- cord-005453-4057qib7 5318 13 p=0.001 p=0.001 NNP cord-005453-4057qib7 5318 14 ) ) -RRB- cord-005453-4057qib7 5318 15 and and CC cord-005453-4057qib7 5318 16 IgM IgM NNP cord-005453-4057qib7 5318 17 ( ( -LRB- cord-005453-4057qib7 5318 18 p=0.003 p=0.003 NNP cord-005453-4057qib7 5318 19 ) ) -RRB- cord-005453-4057qib7 5318 20 , , , cord-005453-4057qib7 5318 21 and and CC cord-005453-4057qib7 5318 22 lower low JJR cord-005453-4057qib7 5318 23 albumin albumin NN cord-005453-4057qib7 5318 24 ( ( -LRB- cord-005453-4057qib7 5318 25 p=0.018 p=0.018 NNP cord-005453-4057qib7 5318 26 ) ) -RRB- cord-005453-4057qib7 5318 27 than than IN cord-005453-4057qib7 5318 28 controls control NNS cord-005453-4057qib7 5318 29 , , , cord-005453-4057qib7 5318 30 without without IN cord-005453-4057qib7 5318 31 differences difference NNS cord-005453-4057qib7 5318 32 between between IN cord-005453-4057qib7 5318 33 other other JJ cord-005453-4057qib7 5318 34 laboratory laboratory NN cord-005453-4057qib7 5318 35 parameters parameter NNS cord-005453-4057qib7 5318 36 . . . cord-005453-4057qib7 5319 1 Univariate Univariate NNP cord-005453-4057qib7 5319 2 analysis analysis NN cord-005453-4057qib7 5319 3 showed show VBD cord-005453-4057qib7 5319 4 that that IN cord-005453-4057qib7 5319 5 among among IN cord-005453-4057qib7 5319 6 cGvHD cgvhd NN cord-005453-4057qib7 5319 7 patients patient NNS cord-005453-4057qib7 5319 8 higher high JJR cord-005453-4057qib7 5319 9 FVIII FVIII NNP cord-005453-4057qib7 5319 10 was be VBD cord-005453-4057qib7 5319 11 associated associate VBN cord-005453-4057qib7 5319 12 with with IN cord-005453-4057qib7 5319 13 worse bad JJR cord-005453-4057qib7 5319 14 Karnofsky Karnofsky NNP cord-005453-4057qib7 5319 15 score score NN cord-005453-4057qib7 5319 16 ( ( -LRB- cord-005453-4057qib7 5319 17 KS KS NNP cord-005453-4057qib7 5319 18 ) ) -RRB- cord-005453-4057qib7 5319 19 ( ( -LRB- cord-005453-4057qib7 5319 20 p=0.031 p=0.031 NNP cord-005453-4057qib7 5319 21 ) ) -RRB- cord-005453-4057qib7 5319 22 and and CC cord-005453-4057qib7 5319 23 performance performance NN cord-005453-4057qib7 5319 24 score score NN cord-005453-4057qib7 5319 25 ( ( -LRB- cord-005453-4057qib7 5319 26 PS PS NNP cord-005453-4057qib7 5319 27 ) ) -RRB- cord-005453-4057qib7 5319 28 ( ( -LRB- cord-005453-4057qib7 5319 29 p=0.030 p=0.030 NNP cord-005453-4057qib7 5319 30 ) ) -RRB- cord-005453-4057qib7 5319 31 , , , cord-005453-4057qib7 5319 32 higher high JJR cord-005453-4057qib7 5319 33 leukocytes leukocyte NNS cord-005453-4057qib7 5319 34 ( ( -LRB- cord-005453-4057qib7 5319 35 p=0.031 p=0.031 NNP cord-005453-4057qib7 5319 36 ) ) -RRB- cord-005453-4057qib7 5319 37 , , , cord-005453-4057qib7 5319 38 cholesterol cholesterol NN cord-005453-4057qib7 5319 39 ( ( -LRB- cord-005453-4057qib7 5319 40 p=0.003 p=0.003 NNP cord-005453-4057qib7 5319 41 ) ) -RRB- cord-005453-4057qib7 5319 42 , , , cord-005453-4057qib7 5319 43 triglycerides triglyceride NNS cord-005453-4057qib7 5319 44 , , , cord-005453-4057qib7 5319 45 AST AST NNP cord-005453-4057qib7 5319 46 , , , cord-005453-4057qib7 5319 47 ALT ALT NNP cord-005453-4057qib7 5319 48 , , , cord-005453-4057qib7 5319 49 GGT GGT NNP cord-005453-4057qib7 5319 50 , , , cord-005453-4057qib7 5319 51 LDH LDH NNP cord-005453-4057qib7 5319 52 , , , cord-005453-4057qib7 5319 53 and and CC cord-005453-4057qib7 5319 54 lower low JJR cord-005453-4057qib7 5319 55 albumin albumin NN cord-005453-4057qib7 5319 56 . . . cord-005453-4057qib7 5320 1 Higher high JJR cord-005453-4057qib7 5320 2 VWF VWF NNP cord-005453-4057qib7 5320 3 : : : cord-005453-4057qib7 5321 1 Ag Ag NNP cord-005453-4057qib7 5321 2 and and CC cord-005453-4057qib7 5321 3 VWF VWF NNP cord-005453-4057qib7 5321 4 : : : cord-005453-4057qib7 5321 5 Ac Ac NNP cord-005453-4057qib7 5321 6 in in IN cord-005453-4057qib7 5321 7 cGvHD cgvhd NN cord-005453-4057qib7 5321 8 patients patient NNS cord-005453-4057qib7 5321 9 were be VBD cord-005453-4057qib7 5321 10 associated associate VBN cord-005453-4057qib7 5321 11 with with IN cord-005453-4057qib7 5321 12 worse bad JJR cord-005453-4057qib7 5321 13 KS KS NNP cord-005453-4057qib7 5321 14 and and CC cord-005453-4057qib7 5321 15 PS PS NNP cord-005453-4057qib7 5321 16 ( ( -LRB- cord-005453-4057qib7 5321 17 p p NN cord-005453-4057qib7 5321 18 < < XX cord-005453-4057qib7 5321 19 0.001 0.001 CD cord-005453-4057qib7 5321 20 ) ) -RRB- cord-005453-4057qib7 5321 21 , , , cord-005453-4057qib7 5321 22 with with IN cord-005453-4057qib7 5321 23 more more RBR cord-005453-4057qib7 5321 24 active active JJ cord-005453-4057qib7 5321 25 cGvHD cgvhd NN cord-005453-4057qib7 5321 26 ( ( -LRB- cord-005453-4057qib7 5321 27 p p NN cord-005453-4057qib7 5321 28 < < XX cord-005453-4057qib7 5321 29 0.001 0.001 CD cord-005453-4057qib7 5321 30 ) ) -RRB- cord-005453-4057qib7 5321 31 , , , cord-005453-4057qib7 5321 32 worse bad JJR cord-005453-4057qib7 5321 33 NIH NIH NNP cord-005453-4057qib7 5321 34 cGvHD cgvhd NN cord-005453-4057qib7 5321 35 liver liver NN cord-005453-4057qib7 5321 36 ( ( -LRB- cord-005453-4057qib7 5321 37 p=0.042 p=0.042 NNP cord-005453-4057qib7 5321 38 ; ; : cord-005453-4057qib7 5321 39 p=0.039 p=0.039 JJ cord-005453-4057qib7 5321 40 ) ) -RRB- cord-005453-4057qib7 5321 41 and and CC cord-005453-4057qib7 5321 42 NIH NIH NNP cord-005453-4057qib7 5321 43 cGvHD cGvHD NNP cord-005453-4057qib7 5321 44 mouth mouth NN cord-005453-4057qib7 5321 45 ( ( -LRB- cord-005453-4057qib7 5321 46 p=0.012 p=0.012 NNP cord-005453-4057qib7 5321 47 ; ; . cord-005453-4057qib7 5322 1 p=0.009 p=0.009 NNP cord-005453-4057qib7 5322 2 ) ) -RRB- cord-005453-4057qib7 5322 3 , , , cord-005453-4057qib7 5322 4 higher high JJR cord-005453-4057qib7 5322 5 total total JJ cord-005453-4057qib7 5322 6 NIH NIH NNP cord-005453-4057qib7 5322 7 score score NN cord-005453-4057qib7 5322 8 ( ( -LRB- cord-005453-4057qib7 5322 9 p=0.044 p=0.044 NNS cord-005453-4057qib7 5322 10 ; ; : cord-005453-4057qib7 5322 11 p=0.005 p=0.005 NNP cord-005453-4057qib7 5322 12 ) ) -RRB- cord-005453-4057qib7 5322 13 , , , cord-005453-4057qib7 5322 14 higher high JJR cord-005453-4057qib7 5322 15 number number NN cord-005453-4057qib7 5322 16 organs organ NNS cord-005453-4057qib7 5322 17 involved involve VBN cord-005453-4057qib7 5322 18 ( ( -LRB- cord-005453-4057qib7 5322 19 p=0.013 p=0.013 NN cord-005453-4057qib7 5322 20 ; ; : cord-005453-4057qib7 5322 21 p=0.003 p=0.003 NNP cord-005453-4057qib7 5322 22 ) ) -RRB- cord-005453-4057qib7 5322 23 , , , cord-005453-4057qib7 5322 24 higher high JJR cord-005453-4057qib7 5322 25 ESR ESR NNP cord-005453-4057qib7 5322 26 , , , cord-005453-4057qib7 5322 27 monocytes monocyte NNS cord-005453-4057qib7 5322 28 , , , cord-005453-4057qib7 5322 29 Ddimers Ddimers NNPS cord-005453-4057qib7 5322 30 , , , cord-005453-4057qib7 5322 31 AST AST NNP cord-005453-4057qib7 5322 32 , , , cord-005453-4057qib7 5322 33 ALT ALT NNP cord-005453-4057qib7 5322 34 , , , cord-005453-4057qib7 5322 35 GGT GGT NNP cord-005453-4057qib7 5322 36 , , , cord-005453-4057qib7 5322 37 LDH LDH NNP cord-005453-4057qib7 5322 38 , , , cord-005453-4057qib7 5322 39 triglycerides triglyceride NNS cord-005453-4057qib7 5322 40 , , , cord-005453-4057qib7 5322 41 β-2-microglobulin β-2-microglobulin ADD cord-005453-4057qib7 5322 42 , , , cord-005453-4057qib7 5322 43 ferritin ferritin NN cord-005453-4057qib7 5322 44 , , , cord-005453-4057qib7 5322 45 total total JJ cord-005453-4057qib7 5322 46 proteins protein NNS cord-005453-4057qib7 5322 47 , , , cord-005453-4057qib7 5322 48 IgA iga NN cord-005453-4057qib7 5322 49 and and CC cord-005453-4057qib7 5322 50 lower low JJR cord-005453-4057qib7 5322 51 albumin albumin NN cord-005453-4057qib7 5322 52 . . . cord-005453-4057qib7 5323 1 MLR MLR NNP cord-005453-4057qib7 5323 2 analysis analysis NN cord-005453-4057qib7 5323 3 showed show VBD cord-005453-4057qib7 5323 4 leukocytes leukocyte NNS cord-005453-4057qib7 5323 5 ( ( -LRB- cord-005453-4057qib7 5323 6 p=0.018 p=0.018 NNP cord-005453-4057qib7 5323 7 ) ) -RRB- cord-005453-4057qib7 5324 1 and and CC cord-005453-4057qib7 5324 2 cholesterol cholesterol NN cord-005453-4057qib7 5324 3 ( ( -LRB- cord-005453-4057qib7 5324 4 p=0.010 p=0.010 ADD cord-005453-4057qib7 5324 5 ) ) -RRB- cord-005453-4057qib7 5325 1 as as IN cord-005453-4057qib7 5325 2 the the DT cord-005453-4057qib7 5325 3 strongest strong JJS cord-005453-4057qib7 5325 4 predictor predictor NN cord-005453-4057qib7 5325 5 of of IN cord-005453-4057qib7 5325 6 FVIII FVIII NNP cord-005453-4057qib7 5325 7 ( ( -LRB- cord-005453-4057qib7 5325 8 r2=49.8 r2=49.8 NNP cord-005453-4057qib7 5325 9 % % NN cord-005453-4057qib7 5325 10 ; ; : cord-005453-4057qib7 5325 11 p p NN cord-005453-4057qib7 5325 12 < < XX cord-005453-4057qib7 5325 13 0.001 0.001 CD cord-005453-4057qib7 5325 14 ) ) -RRB- cord-005453-4057qib7 5325 15 , , , cord-005453-4057qib7 5325 16 while while IN cord-005453-4057qib7 5325 17 strongest strong JJS cord-005453-4057qib7 5325 18 predictor predictor NN cord-005453-4057qib7 5325 19 of of IN cord-005453-4057qib7 5325 20 VWF VWF NNP cord-005453-4057qib7 5325 21 : : : cord-005453-4057qib7 5326 1 Ac Ac NNP cord-005453-4057qib7 5326 2 was be VBD cord-005453-4057qib7 5326 3 number number NN cord-005453-4057qib7 5326 4 of of IN cord-005453-4057qib7 5326 5 organs organ NNS cord-005453-4057qib7 5326 6 involved involve VBN cord-005453-4057qib7 5326 7 by by IN cord-005453-4057qib7 5326 8 cGvHD cGvHD NNP cord-005453-4057qib7 5326 9 ( ( -LRB- cord-005453-4057qib7 5326 10 r2=71.7 r2=71.7 NN cord-005453-4057qib7 5326 11 % % NN cord-005453-4057qib7 5326 12 ; ; : cord-005453-4057qib7 5326 13 p=0.031 p=0.031 NNP cord-005453-4057qib7 5326 14 ) ) -RRB- cord-005453-4057qib7 5326 15 . . . cord-005453-4057qib7 5327 1 Conclusions conclusion NNS cord-005453-4057qib7 5327 2 : : : cord-005453-4057qib7 5328 1 Results result NNS cord-005453-4057qib7 5328 2 of of IN cord-005453-4057qib7 5328 3 this this DT cord-005453-4057qib7 5328 4 study study NN cord-005453-4057qib7 5328 5 detected detect VBD cord-005453-4057qib7 5328 6 high high JJ cord-005453-4057qib7 5328 7 FVIII FVIII NNP cord-005453-4057qib7 5328 8 and and CC cord-005453-4057qib7 5328 9 VWF VWF NNP cord-005453-4057qib7 5328 10 levels level NNS cord-005453-4057qib7 5328 11 in in IN cord-005453-4057qib7 5328 12 cGvHD cgvhd NN cord-005453-4057qib7 5328 13 patients patient NNS cord-005453-4057qib7 5328 14 with with IN cord-005453-4057qib7 5328 15 possible possible JJ cord-005453-4057qib7 5328 16 reflections reflection NNS cord-005453-4057qib7 5328 17 to to IN cord-005453-4057qib7 5328 18 cGvHD cGvHD NNP cord-005453-4057qib7 5328 19 manifestations manifestation NNS cord-005453-4057qib7 5328 20 , , , cord-005453-4057qib7 5328 21 what what WP cord-005453-4057qib7 5328 22 needs need VBZ cord-005453-4057qib7 5328 23 to to TO cord-005453-4057qib7 5328 24 be be VB cord-005453-4057qib7 5328 25 further further RB cord-005453-4057qib7 5328 26 confirmed confirm VBN cord-005453-4057qib7 5328 27 in in IN cord-005453-4057qib7 5328 28 larger large JJR cord-005453-4057qib7 5328 29 longitudinal longitudinal JJ cord-005453-4057qib7 5328 30 studies study NNS cord-005453-4057qib7 5328 31 . . . cord-005453-4057qib7 5329 1 Disclosure disclosure NN cord-005453-4057qib7 5329 2 : : : cord-005453-4057qib7 5330 1 This this DT cord-005453-4057qib7 5330 2 work work NN cord-005453-4057qib7 5330 3 was be VBD cord-005453-4057qib7 5330 4 supported support VBN cord-005453-4057qib7 5330 5 , , , cord-005453-4057qib7 5330 6 in in IN cord-005453-4057qib7 5330 7 part part NN cord-005453-4057qib7 5330 8 , , , cord-005453-4057qib7 5330 9 by by IN cord-005453-4057qib7 5330 10 the the DT cord-005453-4057qib7 5330 11 Unity Unity NNP cord-005453-4057qib7 5330 12 Through Through NNP cord-005453-4057qib7 5330 13 Knowledge Knowledge NNP cord-005453-4057qib7 5330 14 Fund Fund NNP cord-005453-4057qib7 5330 15 project project NN cord-005453-4057qib7 5330 16 entitled entitle VBN cord-005453-4057qib7 5330 17 " " `` cord-005453-4057qib7 5330 18 Clinical clinical JJ cord-005453-4057qib7 5330 19 and and CC cord-005453-4057qib7 5330 20 biological biological JJ cord-005453-4057qib7 5330 21 factors factor NNS cord-005453-4057qib7 5330 22 determining determine VBG cord-005453-4057qib7 5330 23 severity severity NN cord-005453-4057qib7 5330 24 and and CC cord-005453-4057qib7 5330 25 activity activity NN cord-005453-4057qib7 5330 26 of of IN cord-005453-4057qib7 5330 27 chronic chronic JJ cord-005453-4057qib7 5330 28 Graft graft NN cord-005453-4057qib7 5330 29 - - HYPH cord-005453-4057qib7 5330 30 versus versus IN cord-005453-4057qib7 5330 31 - - HYPH cord-005453-4057qib7 5330 32 Host host NN cord-005453-4057qib7 5330 33 disease disease NN cord-005453-4057qib7 5330 34 after after IN cord-005453-4057qib7 5330 35 allogeneic allogeneic JJ cord-005453-4057qib7 5330 36 hematopoietic hematopoietic JJ cord-005453-4057qib7 5330 37 stem stem NN cord-005453-4057qib7 5330 38 cell cell NN cord-005453-4057qib7 5330 39 transplantation transplantation NN cord-005453-4057qib7 5330 40 " " '' cord-005453-4057qib7 5330 41 , , , cord-005453-4057qib7 5330 42 and and CC cord-005453-4057qib7 5330 43 also also RB cord-005453-4057qib7 5330 44 , , , cord-005453-4057qib7 5330 45 in in IN cord-005453-4057qib7 5330 46 part part NN cord-005453-4057qib7 5330 47 , , , cord-005453-4057qib7 5330 48 by by IN cord-005453-4057qib7 5330 49 the the DT cord-005453-4057qib7 5330 50 Croatian Croatian NNP cord-005453-4057qib7 5330 51 Science Science NNP cord-005453-4057qib7 5330 52 Foundation Foundation NNP cord-005453-4057qib7 5330 53 project project NN cord-005453-4057qib7 5330 54 entitled entitle VBN cord-005453-4057qib7 5330 55 " " `` cord-005453-4057qib7 5330 56 New new JJ cord-005453-4057qib7 5330 57 biomarkers biomarker NNS cord-005453-4057qib7 5330 58 for for IN cord-005453-4057qib7 5330 59 chronic chronic JJ cord-005453-4057qib7 5330 60 Graft graft NN cord-005453-4057qib7 5330 61 - - HYPH cord-005453-4057qib7 5330 62 versus versus IN cord-005453-4057qib7 5330 63 - - HYPH cord-005453-4057qib7 5330 64 Host host NN cord-005453-4057qib7 5330 65 disease disease NN cord-005453-4057qib7 5330 66 " " '' cord-005453-4057qib7 5330 67 . . . cord-005453-4057qib7 5331 1 Antonela Antonela NNP cord-005453-4057qib7 5331 2 Samardzic Samardzic NNP cord-005453-4057qib7 5331 3 -Work -Work NNP cord-005453-4057qib7 5332 1 financed finance VBN cord-005453-4057qib7 5332 2 by by IN cord-005453-4057qib7 5332 3 the the DT cord-005453-4057qib7 5332 4 Croatian Croatian NNP cord-005453-4057qib7 5332 5 Science Science NNP cord-005453-4057qib7 5332 6 Fondations`"Young Fondations`"Young . cord-005453-4057qib7 5333 1 researchers`career researchers`career NNP cord-005453-4057qib7 5333 2 development development NN cord-005453-4057qib7 5333 3 project project NN cord-005453-4057qib7 5333 4 -training -training NN cord-005453-4057qib7 5333 5 of of IN cord-005453-4057qib7 5333 6 doctoral doctoral JJ cord-005453-4057qib7 5333 7 students student NNS cord-005453-4057qib7 5334 1 " " `` cord-005453-4057qib7 5334 2 Background background NN cord-005453-4057qib7 5334 3 : : : cord-005453-4057qib7 5335 1 Thrombotic thrombotic JJ cord-005453-4057qib7 5335 2 microangiopathy microangiopathy NN cord-005453-4057qib7 5335 3 ( ( -LRB- cord-005453-4057qib7 5335 4 TMA TMA NNP cord-005453-4057qib7 5335 5 ) ) -RRB- cord-005453-4057qib7 5335 6 is be VBZ cord-005453-4057qib7 5335 7 a a DT cord-005453-4057qib7 5335 8 severe severe JJ cord-005453-4057qib7 5335 9 complication complication NN cord-005453-4057qib7 5335 10 of of IN cord-005453-4057qib7 5335 11 allogeneic allogeneic JJ cord-005453-4057qib7 5335 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 5335 13 cell cell NN cord-005453-4057qib7 5335 14 transplantation transplantation NN cord-005453-4057qib7 5335 15 ( ( -LRB- cord-005453-4057qib7 5335 16 HCT HCT NNP cord-005453-4057qib7 5335 17 ) ) -RRB- cord-005453-4057qib7 5335 18 with with IN cord-005453-4057qib7 5335 19 multisystem multisystem JJ cord-005453-4057qib7 5335 20 involvement involvement NN cord-005453-4057qib7 5335 21 . . . cord-005453-4057qib7 5336 1 A a DT cord-005453-4057qib7 5336 2 few few JJ cord-005453-4057qib7 5336 3 recent recent JJ cord-005453-4057qib7 5336 4 reports report NNS cord-005453-4057qib7 5336 5 have have VBP cord-005453-4057qib7 5336 6 recognized recognize VBN cord-005453-4057qib7 5336 7 evidence evidence NN cord-005453-4057qib7 5336 8 of of IN cord-005453-4057qib7 5336 9 TMA TMA NNP cord-005453-4057qib7 5336 10 in in IN cord-005453-4057qib7 5336 11 the the DT cord-005453-4057qib7 5336 12 intestinal intestinal JJ cord-005453-4057qib7 5336 13 vasculature vasculature NN cord-005453-4057qib7 5336 14 ( ( -LRB- cord-005453-4057qib7 5336 15 intestinal intestinal JJ cord-005453-4057qib7 5336 16 TMA TMA NNP cord-005453-4057qib7 5336 17 / / SYM cord-005453-4057qib7 5336 18 iTMA itma NN cord-005453-4057qib7 5336 19 ) ) -RRB- cord-005453-4057qib7 5336 20 of of IN cord-005453-4057qib7 5336 21 patients patient NNS cord-005453-4057qib7 5336 22 with with IN cord-005453-4057qib7 5336 23 graft graft NN cord-005453-4057qib7 5336 24 - - HYPH cord-005453-4057qib7 5336 25 versus versus IN cord-005453-4057qib7 5336 26 - - HYPH cord-005453-4057qib7 5336 27 host host NN cord-005453-4057qib7 5336 28 disease disease NN cord-005453-4057qib7 5336 29 ( ( -LRB- cord-005453-4057qib7 5336 30 GVHD GVHD NNP cord-005453-4057qib7 5336 31 ) ) -RRB- cord-005453-4057qib7 5336 32 with with IN cord-005453-4057qib7 5336 33 or or CC cord-005453-4057qib7 5336 34 without without IN cord-005453-4057qib7 5336 35 TMA TMA NNP cord-005453-4057qib7 5336 36 . . . cord-005453-4057qib7 5337 1 We -PRON- PRP cord-005453-4057qib7 5337 2 aimed aim VBD cord-005453-4057qib7 5337 3 to to TO cord-005453-4057qib7 5337 4 identify identify VB cord-005453-4057qib7 5337 5 patients patient NNS cord-005453-4057qib7 5337 6 with with IN cord-005453-4057qib7 5337 7 iTMA itma PRP cord-005453-4057qib7 5337 8 and and CC cord-005453-4057qib7 5337 9 describe describe VB cord-005453-4057qib7 5337 10 histological histological JJ cord-005453-4057qib7 5337 11 , , , cord-005453-4057qib7 5337 12 clinical clinical JJ cord-005453-4057qib7 5337 13 and and CC cord-005453-4057qib7 5337 14 prognostic prognostic JJ cord-005453-4057qib7 5337 15 features feature NNS cord-005453-4057qib7 5337 16 . . . cord-005453-4057qib7 5338 1 Methods method NNS cord-005453-4057qib7 5338 2 : : : cord-005453-4057qib7 5338 3 We -PRON- PRP cord-005453-4057qib7 5338 4 prospectively prospectively RB cord-005453-4057qib7 5338 5 evaluated evaluate VBD cord-005453-4057qib7 5338 6 available available JJ cord-005453-4057qib7 5338 7 endoscopic endoscopic JJ cord-005453-4057qib7 5338 8 samples sample NNS cord-005453-4057qib7 5338 9 ( ( -LRB- cord-005453-4057qib7 5338 10 stomach stomach NN cord-005453-4057qib7 5338 11 and/or and/or CC cord-005453-4057qib7 5338 12 colon colon NN cord-005453-4057qib7 5338 13 ) ) -RRB- cord-005453-4057qib7 5338 14 from from IN cord-005453-4057qib7 5338 15 consecutive consecutive JJ cord-005453-4057qib7 5338 16 adult adult NN cord-005453-4057qib7 5338 17 HCT hct NN cord-005453-4057qib7 5338 18 recipients recipient NNS cord-005453-4057qib7 5338 19 for for IN cord-005453-4057qib7 5338 20 previously previously RB cord-005453-4057qib7 5338 21 described describe VBN cord-005453-4057qib7 5338 22 histopathologic histopathologic JJ cord-005453-4057qib7 5338 23 signs sign NNS cord-005453-4057qib7 5338 24 of of IN cord-005453-4057qib7 5338 25 iTMA itma JJ cord-005453-4057qib7 5338 26 ( ( -LRB- cord-005453-4057qib7 5338 27 January January NNP cord-005453-4057qib7 5338 28 2017-September 2017-september CD cord-005453-4057qib7 5338 29 2018 2018 CD cord-005453-4057qib7 5338 30 ) ) -RRB- cord-005453-4057qib7 5338 31 . . . cord-005453-4057qib7 5339 1 Systemic systemic JJ cord-005453-4057qib7 5339 2 TMA TMA NNP cord-005453-4057qib7 5339 3 was be VBD cord-005453-4057qib7 5339 4 diagnosed diagnose VBN cord-005453-4057qib7 5339 5 according accord VBG cord-005453-4057qib7 5339 6 to to IN cord-005453-4057qib7 5339 7 the the DT cord-005453-4057qib7 5339 8 International International NNP cord-005453-4057qib7 5339 9 Working Working NNP cord-005453-4057qib7 5339 10 Group Group NNP cord-005453-4057qib7 5339 11 Criteria Criteria NNP cord-005453-4057qib7 5339 12 . . . cord-005453-4057qib7 5340 1 We -PRON- PRP cord-005453-4057qib7 5340 2 compared compare VBD cord-005453-4057qib7 5340 3 findings finding NNS cord-005453-4057qib7 5340 4 among among IN cord-005453-4057qib7 5340 5 3 3 CD cord-005453-4057qib7 5340 6 clinical clinical JJ cord-005453-4057qib7 5340 7 groups group NNS cord-005453-4057qib7 5340 8 : : : cord-005453-4057qib7 5341 1 GVHD GVHD NNP cord-005453-4057qib7 5341 2 / / SYM cord-005453-4057qib7 5341 3 systemic systemic JJ cord-005453-4057qib7 5341 4 TMA TMA NNP cord-005453-4057qib7 5341 5 , , , cord-005453-4057qib7 5341 6 GVHD GVHD NNP cord-005453-4057qib7 5341 7 / / , cord-005453-4057qib7 5341 8 no no DT cord-005453-4057qib7 5341 9 systemic systemic JJ cord-005453-4057qib7 5341 10 TMA tma NN cord-005453-4057qib7 5341 11 and and CC cord-005453-4057qib7 5341 12 no no DT cord-005453-4057qib7 5341 13 GVHD/ GVHD/ NNP cord-005453-4057qib7 5342 1 no no DT cord-005453-4057qib7 5342 2 TMA TMA NNP cord-005453-4057qib7 5342 3 . . . cord-005453-4057qib7 5343 1 Results result NNS cord-005453-4057qib7 5343 2 : : : cord-005453-4057qib7 5344 1 We -PRON- PRP cord-005453-4057qib7 5344 2 studied study VBD cord-005453-4057qib7 5344 3 20 20 CD cord-005453-4057qib7 5344 4 patients patient NNS cord-005453-4057qib7 5344 5 , , , cord-005453-4057qib7 5344 6 5 5 CD cord-005453-4057qib7 5344 7 classified classify VBN cord-005453-4057qib7 5344 8 as as IN cord-005453-4057qib7 5344 9 GVHD/ GVHD/ NNP cord-005453-4057qib7 5344 10 systemic systemic JJ cord-005453-4057qib7 5344 11 TMA TMA NNP cord-005453-4057qib7 5344 12 , , , cord-005453-4057qib7 5344 13 11 11 CD cord-005453-4057qib7 5344 14 GVHD/ GVHD/ NNP cord-005453-4057qib7 5345 1 no no DT cord-005453-4057qib7 5345 2 systemic systemic JJ cord-005453-4057qib7 5345 3 TMA TMA NNP cord-005453-4057qib7 5345 4 and and CC cord-005453-4057qib7 5345 5 4 4 CD cord-005453-4057qib7 5345 6 no no DT cord-005453-4057qib7 5345 7 GVHD/ GVHD/ NNP cord-005453-4057qib7 5346 1 no no DT cord-005453-4057qib7 5346 2 TMA TMA NNP cord-005453-4057qib7 5346 3 . . . cord-005453-4057qib7 5347 1 Baseline baseline JJ cord-005453-4057qib7 5347 2 transplant transplant NN cord-005453-4057qib7 5347 3 characteristics characteristic NNS cord-005453-4057qib7 5347 4 ( ( -LRB- cord-005453-4057qib7 5347 5 age age NN cord-005453-4057qib7 5347 6 , , , cord-005453-4057qib7 5347 7 donor donor NN cord-005453-4057qib7 5347 8 , , , cord-005453-4057qib7 5347 9 HLA HLA NNP cord-005453-4057qib7 5347 10 matching matching NN cord-005453-4057qib7 5347 11 , , , cord-005453-4057qib7 5347 12 conditioning conditioning NN cord-005453-4057qib7 5347 13 ) ) -RRB- cord-005453-4057qib7 5347 14 did do VBD cord-005453-4057qib7 5347 15 not not RB cord-005453-4057qib7 5347 16 differ differ VB cord-005453-4057qib7 5347 17 significantly significantly RB cord-005453-4057qib7 5347 18 among among IN cord-005453-4057qib7 5347 19 groups group NNS cord-005453-4057qib7 5347 20 . . . cord-005453-4057qib7 5348 1 Histological Histological NNP cord-005453-4057qib7 5348 2 features feature NNS cord-005453-4057qib7 5348 3 of of IN cord-005453-4057qib7 5348 4 iTMA itma NN cord-005453-4057qib7 5348 5 , , , cord-005453-4057qib7 5348 6 including include VBG cord-005453-4057qib7 5348 7 loss loss NN cord-005453-4057qib7 5348 8 of of IN cord-005453-4057qib7 5348 9 glands gland NNS cord-005453-4057qib7 5348 10 , , , cord-005453-4057qib7 5348 11 total total JJ cord-005453-4057qib7 5348 12 denudation denudation NN cord-005453-4057qib7 5348 13 of of IN cord-005453-4057qib7 5348 14 mucosa mucosa NN cord-005453-4057qib7 5348 15 , , , cord-005453-4057qib7 5348 16 apoptosis apoptosis NN cord-005453-4057qib7 5348 17 and and CC cord-005453-4057qib7 5348 18 detachment detachment NN cord-005453-4057qib7 5348 19 of of IN cord-005453-4057qib7 5348 20 endothelial endothelial JJ cord-005453-4057qib7 5348 21 cells cell NNS cord-005453-4057qib7 5348 22 , , , cord-005453-4057qib7 5348 23 intraluminal intraluminal JJ cord-005453-4057qib7 5348 24 fibrin fibrin NN cord-005453-4057qib7 5348 25 , , , cord-005453-4057qib7 5348 26 intraluminal intraluminal JJ cord-005453-4057qib7 5348 27 microthrombi microthrombi NN cord-005453-4057qib7 5348 28 and and CC cord-005453-4057qib7 5348 29 mucosal mucosal JJ cord-005453-4057qib7 5348 30 hemorrhage hemorrhage NN cord-005453-4057qib7 5348 31 were be VBD cord-005453-4057qib7 5348 32 found find VBN cord-005453-4057qib7 5348 33 in in IN cord-005453-4057qib7 5348 34 6 6 CD cord-005453-4057qib7 5348 35 patients patient NNS cord-005453-4057qib7 5348 36 . . . cord-005453-4057qib7 5349 1 Previously previously RB cord-005453-4057qib7 5349 2 described describe VBN cord-005453-4057qib7 5349 3 features feature NNS cord-005453-4057qib7 5349 4 of of IN cord-005453-4057qib7 5349 5 intraluminal intraluminal JJ cord-005453-4057qib7 5349 6 schistocytes schistocyte NNS cord-005453-4057qib7 5349 7 were be VBD cord-005453-4057qib7 5349 8 not not RB cord-005453-4057qib7 5349 9 observed observe VBN cord-005453-4057qib7 5349 10 in in IN cord-005453-4057qib7 5349 11 our -PRON- PRP$ cord-005453-4057qib7 5349 12 patients patient NNS cord-005453-4057qib7 5349 13 . . . cord-005453-4057qib7 5350 1 Interestingly interestingly RB cord-005453-4057qib7 5350 2 , , , cord-005453-4057qib7 5350 3 loss loss NN cord-005453-4057qib7 5350 4 of of IN cord-005453-4057qib7 5350 5 glands gland NNS cord-005453-4057qib7 5350 6 , , , cord-005453-4057qib7 5350 7 total total JJ cord-005453-4057qib7 5350 8 denudation denudation NN cord-005453-4057qib7 5350 9 of of IN cord-005453-4057qib7 5350 10 mucosa mucosa NN cord-005453-4057qib7 5350 11 , , , cord-005453-4057qib7 5350 12 apoptosis apoptosis NN cord-005453-4057qib7 5350 13 and and CC cord-005453-4057qib7 5350 14 detachment detachment NN cord-005453-4057qib7 5350 15 of of IN cord-005453-4057qib7 5350 16 endothelial endothelial JJ cord-005453-4057qib7 5350 17 cells cell NNS cord-005453-4057qib7 5350 18 were be VBD cord-005453-4057qib7 5350 19 also also RB cord-005453-4057qib7 5350 20 found find VBN cord-005453-4057qib7 5350 21 in in IN cord-005453-4057qib7 5350 22 patients patient NNS cord-005453-4057qib7 5350 23 with with IN cord-005453-4057qib7 5350 24 GVHD GVHD NNP cord-005453-4057qib7 5350 25 and and CC cord-005453-4057qib7 5350 26 no no DT cord-005453-4057qib7 5350 27 iTMA itma RB cord-005453-4057qib7 5350 28 , , , cord-005453-4057qib7 5350 29 suggesting suggest VBG cord-005453-4057qib7 5350 30 that that IN cord-005453-4057qib7 5350 31 these these DT cord-005453-4057qib7 5350 32 features feature NNS cord-005453-4057qib7 5350 33 are be VBP cord-005453-4057qib7 5350 34 not not RB cord-005453-4057qib7 5350 35 pathognomonic pathognomonic JJ cord-005453-4057qib7 5350 36 of of IN cord-005453-4057qib7 5350 37 iTMA itma PRP cord-005453-4057qib7 5350 38 . . . cord-005453-4057qib7 5351 1 Among among IN cord-005453-4057qib7 5351 2 6 6 CD cord-005453-4057qib7 5351 3 iTMA iTMA NNS cord-005453-4057qib7 5351 4 patients patient NNS cord-005453-4057qib7 5351 5 , , , cord-005453-4057qib7 5351 6 two two CD cord-005453-4057qib7 5351 7 patients patient NNS cord-005453-4057qib7 5351 8 were be VBD cord-005453-4057qib7 5351 9 classified classify VBN cord-005453-4057qib7 5351 10 in in IN cord-005453-4057qib7 5351 11 the the DT cord-005453-4057qib7 5351 12 clinical clinical JJ cord-005453-4057qib7 5351 13 group group NN cord-005453-4057qib7 5351 14 of of IN cord-005453-4057qib7 5351 15 acute acute JJ cord-005453-4057qib7 5351 16 GVHD GVHD NNP cord-005453-4057qib7 5351 17 / / SYM cord-005453-4057qib7 5351 18 systemic systemic JJ cord-005453-4057qib7 5351 19 TMA TMA NNP cord-005453-4057qib7 5351 20 , , , cord-005453-4057qib7 5351 21 while while IN cord-005453-4057qib7 5351 22 the the DT cord-005453-4057qib7 5351 23 other other JJ cord-005453-4057qib7 5351 24 4 4 CD cord-005453-4057qib7 5351 25 patients patient NNS cord-005453-4057qib7 5351 26 had have VBD cord-005453-4057qib7 5351 27 clinical clinical JJ cord-005453-4057qib7 5351 28 and and CC cord-005453-4057qib7 5351 29 histopathological histopathological JJ cord-005453-4057qib7 5351 30 features feature NNS cord-005453-4057qib7 5351 31 of of IN cord-005453-4057qib7 5351 32 iTMA iTMA NNS cord-005453-4057qib7 5351 33 and and CC cord-005453-4057qib7 5351 34 severe severe JJ cord-005453-4057qib7 5351 35 grade grade NN cord-005453-4057qib7 5351 36 III III NNP cord-005453-4057qib7 5351 37 - - HYPH cord-005453-4057qib7 5351 38 IV IV NNP cord-005453-4057qib7 5351 39 steroid steroid NN cord-005453-4057qib7 5351 40 - - HYPH cord-005453-4057qib7 5351 41 refractory refractory JJ cord-005453-4057qib7 5351 42 acute acute JJ cord-005453-4057qib7 5351 43 GVHD GVHD NNP cord-005453-4057qib7 5351 44 ( ( -LRB- cord-005453-4057qib7 5351 45 3 3 CD cord-005453-4057qib7 5351 46 patients patient NNS cord-005453-4057qib7 5351 47 ) ) -RRB- cord-005453-4057qib7 5351 48 or or CC cord-005453-4057qib7 5351 49 extensive extensive JJ cord-005453-4057qib7 5351 50 chronic chronic JJ cord-005453-4057qib7 5351 51 GVHD GVHD NNP cord-005453-4057qib7 5351 52 ( ( -LRB- cord-005453-4057qib7 5351 53 1 1 CD cord-005453-4057qib7 5351 54 patient patient NN cord-005453-4057qib7 5351 55 ) ) -RRB- cord-005453-4057qib7 5351 56 but but CC cord-005453-4057qib7 5351 57 no no DT cord-005453-4057qib7 5351 58 evidence evidence NN cord-005453-4057qib7 5351 59 of of IN cord-005453-4057qib7 5351 60 systemic systemic JJ cord-005453-4057qib7 5351 61 TMA TMA NNP cord-005453-4057qib7 5351 62 . . . cord-005453-4057qib7 5352 1 In in IN cord-005453-4057qib7 5352 2 the the DT cord-005453-4057qib7 5352 3 majority majority NN cord-005453-4057qib7 5352 4 of of IN cord-005453-4057qib7 5352 5 patients patient NNS cord-005453-4057qib7 5352 6 ( ( -LRB- cord-005453-4057qib7 5352 7 5/6 5/6 CD cord-005453-4057qib7 5352 8 ) ) -RRB- cord-005453-4057qib7 5352 9 , , , cord-005453-4057qib7 5352 10 iTMA itma PRP cord-005453-4057qib7 5352 11 occurred occur VBD cord-005453-4057qib7 5352 12 during during IN cord-005453-4057qib7 5352 13 the the DT cord-005453-4057qib7 5352 14 early early JJ cord-005453-4057qib7 5352 15 posttransplant posttransplant NN cord-005453-4057qib7 5352 16 period period NN cord-005453-4057qib7 5352 17 at at IN cord-005453-4057qib7 5352 18 1.7 1.7 CD cord-005453-4057qib7 5352 19 ( ( -LRB- cord-005453-4057qib7 5352 20 0.9 0.9 CD cord-005453-4057qib7 5352 21 - - SYM cord-005453-4057qib7 5352 22 4 4 CD cord-005453-4057qib7 5352 23 ) ) -RRB- cord-005453-4057qib7 5352 24 months month NNS cord-005453-4057qib7 5352 25 . . . cord-005453-4057qib7 5353 1 Clinical clinical JJ cord-005453-4057qib7 5353 2 features feature NNS cord-005453-4057qib7 5353 3 ( ( -LRB- cord-005453-4057qib7 5353 4 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 5353 5 bleeding bleeding NN cord-005453-4057qib7 5353 6 , , , cord-005453-4057qib7 5353 7 diarrhea diarrhea NN cord-005453-4057qib7 5353 8 , , , cord-005453-4057qib7 5353 9 pain pain NN cord-005453-4057qib7 5353 10 , , , cord-005453-4057qib7 5353 11 nausea nausea NN cord-005453-4057qib7 5353 12 ) ) -RRB- cord-005453-4057qib7 5353 13 presented present VBD cord-005453-4057qib7 5353 14 no no DT cord-005453-4057qib7 5353 15 differences difference NNS cord-005453-4057qib7 5353 16 between between IN cord-005453-4057qib7 5353 17 patients patient NNS cord-005453-4057qib7 5353 18 with with IN cord-005453-4057qib7 5353 19 or or CC cord-005453-4057qib7 5353 20 without without IN cord-005453-4057qib7 5353 21 iTMA itma PRP cord-005453-4057qib7 5353 22 . . . cord-005453-4057qib7 5354 1 Prognosis prognosis NN cord-005453-4057qib7 5354 2 was be VBD cord-005453-4057qib7 5354 3 poor poor JJ cord-005453-4057qib7 5354 4 for for IN cord-005453-4057qib7 5354 5 patients patient NNS cord-005453-4057qib7 5354 6 with with IN cord-005453-4057qib7 5354 7 iTMA itma PRP cord-005453-4057qib7 5354 8 who who WP cord-005453-4057qib7 5354 9 suffered suffer VBD cord-005453-4057qib7 5354 10 from from IN cord-005453-4057qib7 5354 11 a a DT cord-005453-4057qib7 5354 12 significantly significantly RB cord-005453-4057qib7 5354 13 higher high JJR cord-005453-4057qib7 5354 14 mortality mortality NN cord-005453-4057qib7 5354 15 rate rate NN cord-005453-4057qib7 5354 16 of of IN cord-005453-4057qib7 5354 17 83 83 CD cord-005453-4057qib7 5354 18 % % NN cord-005453-4057qib7 5354 19 compared compare VBN cord-005453-4057qib7 5354 20 to to IN cord-005453-4057qib7 5354 21 the the DT cord-005453-4057qib7 5354 22 rest rest NN cord-005453-4057qib7 5354 23 patient patient JJ cord-005453-4057qib7 5354 24 population population NN cord-005453-4057qib7 5354 25 ( ( -LRB- cord-005453-4057qib7 5354 26 p=0.014 p=0.014 NNS cord-005453-4057qib7 5354 27 ) ) -RRB- cord-005453-4057qib7 5354 28 . . . cord-005453-4057qib7 5355 1 With with IN cord-005453-4057qib7 5355 2 a a DT cord-005453-4057qib7 5355 3 median median JJ cord-005453-4057qib7 5355 4 follow follow NN cord-005453-4057qib7 5355 5 - - HYPH cord-005453-4057qib7 5355 6 up up NN cord-005453-4057qib7 5355 7 of of IN cord-005453-4057qib7 5355 8 11.1 11.1 CD cord-005453-4057qib7 5355 9 ( ( -LRB- cord-005453-4057qib7 5355 10 2.1 2.1 CD cord-005453-4057qib7 5355 11 - - SYM cord-005453-4057qib7 5355 12 67.5 67.5 CD cord-005453-4057qib7 5355 13 ) ) -RRB- cord-005453-4057qib7 5355 14 months month NNS cord-005453-4057qib7 5355 15 , , , cord-005453-4057qib7 5355 16 1year 1year CD cord-005453-4057qib7 5355 17 overall overall JJ cord-005453-4057qib7 5355 18 survival survival NN cord-005453-4057qib7 5355 19 probability probability NN cord-005453-4057qib7 5355 20 ( ( -LRB- cord-005453-4057qib7 5355 21 OS OS NNP cord-005453-4057qib7 5355 22 ) ) -RRB- cord-005453-4057qib7 5355 23 was be VBD cord-005453-4057qib7 5355 24 22.2 22.2 CD cord-005453-4057qib7 5355 25 for for IN cord-005453-4057qib7 5355 26 iTMA iTMA NNS cord-005453-4057qib7 5355 27 , , , cord-005453-4057qib7 5355 28 55 55 CD cord-005453-4057qib7 5355 29 % % NN cord-005453-4057qib7 5355 30 for for IN cord-005453-4057qib7 5355 31 GVHD GVHD NNP cord-005453-4057qib7 5355 32 and and CC cord-005453-4057qib7 5355 33 60 60 CD cord-005453-4057qib7 5355 34 % % NN cord-005453-4057qib7 5355 35 for for IN cord-005453-4057qib7 5355 36 systemic systemic JJ cord-005453-4057qib7 5355 37 TMA TMA NNP cord-005453-4057qib7 5355 38 . . . cord-005453-4057qib7 5356 1 Unfavorable unfavorable JJ cord-005453-4057qib7 5356 2 predictive predictive JJ cord-005453-4057qib7 5356 3 factors factor NNS cord-005453-4057qib7 5356 4 for for IN cord-005453-4057qib7 5356 5 OS OS NNP cord-005453-4057qib7 5356 6 were be VBD cord-005453-4057qib7 5356 7 iTMA itma XX cord-005453-4057qib7 5357 1 ( ( -LRB- cord-005453-4057qib7 5357 2 p=0.048 p=0.048 NNP cord-005453-4057qib7 5357 3 ) ) -RRB- cord-005453-4057qib7 5357 4 , , , cord-005453-4057qib7 5357 5 HLA HLA NNP cord-005453-4057qib7 5357 6 mismatched mismatched JJ cord-005453-4057qib7 5357 7 donors donor NNS cord-005453-4057qib7 5357 8 ( ( -LRB- cord-005453-4057qib7 5357 9 p=0.008 p=0.008 NNP cord-005453-4057qib7 5357 10 ) ) -RRB- cord-005453-4057qib7 5357 11 and and CC cord-005453-4057qib7 5357 12 gastro gastro JJ cord-005453-4057qib7 5357 13 - - JJ cord-005453-4057qib7 5357 14 intestinal intestinal JJ cord-005453-4057qib7 5357 15 bleeding bleeding NN cord-005453-4057qib7 5357 16 ( ( -LRB- cord-005453-4057qib7 5357 17 p=0.021 p=0.021 NNP cord-005453-4057qib7 5357 18 ) ) -RRB- cord-005453-4057qib7 5357 19 . . . cord-005453-4057qib7 5358 1 Conclusions conclusion NNS cord-005453-4057qib7 5358 2 : : : cord-005453-4057qib7 5359 1 Intestinal intestinal JJ cord-005453-4057qib7 5359 2 TMA TMA NNP cord-005453-4057qib7 5359 3 has have VBZ cord-005453-4057qib7 5359 4 emerged emerge VBN cord-005453-4057qib7 5359 5 as as IN cord-005453-4057qib7 5359 6 a a DT cord-005453-4057qib7 5359 7 novel novel JJ cord-005453-4057qib7 5359 8 distinct distinct JJ cord-005453-4057qib7 5359 9 entity entity NN cord-005453-4057qib7 5359 10 in in IN cord-005453-4057qib7 5359 11 patients patient NNS cord-005453-4057qib7 5359 12 with with IN cord-005453-4057qib7 5359 13 GVHD GVHD NNP cord-005453-4057qib7 5359 14 and/or and/or CC cord-005453-4057qib7 5359 15 systemic systemic JJ cord-005453-4057qib7 5359 16 TMA tma NN cord-005453-4057qib7 5359 17 . . . cord-005453-4057qib7 5360 1 Distinct distinct JJ cord-005453-4057qib7 5360 2 histological histological JJ cord-005453-4057qib7 5360 3 features feature NNS cord-005453-4057qib7 5360 4 may may MD cord-005453-4057qib7 5360 5 be be VB cord-005453-4057qib7 5360 6 useful useful JJ cord-005453-4057qib7 5360 7 in in IN cord-005453-4057qib7 5360 8 differential differential JJ cord-005453-4057qib7 5360 9 diagnosis diagnosis NN cord-005453-4057qib7 5360 10 of of IN cord-005453-4057qib7 5360 11 these these DT cord-005453-4057qib7 5360 12 severe severe JJ cord-005453-4057qib7 5360 13 HCT hct NN cord-005453-4057qib7 5360 14 complications complication NNS cord-005453-4057qib7 5360 15 . . . cord-005453-4057qib7 5361 1 Mortality mortality NN cord-005453-4057qib7 5361 2 rates rate NNS cord-005453-4057qib7 5361 3 higher high JJR cord-005453-4057qib7 5361 4 than than IN cord-005453-4057qib7 5361 5 those those DT cord-005453-4057qib7 5361 6 of of IN cord-005453-4057qib7 5361 7 systemic systemic JJ cord-005453-4057qib7 5361 8 TMA TMA NNP cord-005453-4057qib7 5361 9 highlight highlight VBP cord-005453-4057qib7 5361 10 the the DT cord-005453-4057qib7 5361 11 need need NN cord-005453-4057qib7 5361 12 of of IN cord-005453-4057qib7 5361 13 proper proper JJ cord-005453-4057qib7 5361 14 recognition recognition NN cord-005453-4057qib7 5361 15 of of IN cord-005453-4057qib7 5361 16 iTMA itma XX cord-005453-4057qib7 5361 17 that that WDT cord-005453-4057qib7 5361 18 needs need VBZ cord-005453-4057qib7 5361 19 to to TO cord-005453-4057qib7 5361 20 be be VB cord-005453-4057qib7 5361 21 further further RB cord-005453-4057qib7 5361 22 studied study VBN cord-005453-4057qib7 5361 23 in in IN cord-005453-4057qib7 5361 24 terms term NNS cord-005453-4057qib7 5361 25 of of IN cord-005453-4057qib7 5361 26 diagnostic diagnostic JJ cord-005453-4057qib7 5361 27 and and CC cord-005453-4057qib7 5361 28 therapeutic therapeutic JJ cord-005453-4057qib7 5361 29 potential potential NN cord-005453-4057qib7 5361 30 . . . cord-005453-4057qib7 5362 1 Disclosure disclosure NN cord-005453-4057qib7 5362 2 : : : cord-005453-4057qib7 5363 1 E.G. E.G. NNS cord-005453-4057qib7 5363 2 was be VBD cord-005453-4057qib7 5363 3 supported support VBN cord-005453-4057qib7 5363 4 by by IN cord-005453-4057qib7 5363 5 the the DT cord-005453-4057qib7 5363 6 European European NNP cord-005453-4057qib7 5363 7 Hematology Hematology NNP cord-005453-4057qib7 5363 8 Association Association NNP cord-005453-4057qib7 5363 9 Clinical Clinical NNP cord-005453-4057qib7 5363 10 Research Research NNP cord-005453-4057qib7 5363 11 Grant Grant NNP cord-005453-4057qib7 5363 12 . . . cord-005453-4057qib7 5364 1 The the DT cord-005453-4057qib7 5364 2 remaining remain VBG cord-005453-4057qib7 5364 3 authors author NNS cord-005453-4057qib7 5364 4 declare declare VBP cord-005453-4057qib7 5364 5 no no DT cord-005453-4057qib7 5364 6 competing compete VBG cord-005453-4057qib7 5364 7 financial financial JJ cord-005453-4057qib7 5364 8 interest interest NN cord-005453-4057qib7 5364 9 . . . cord-005453-4057qib7 5365 1 The the DT cord-005453-4057qib7 5365 2 beneficial beneficial JJ cord-005453-4057qib7 5365 3 effects effect NNS cord-005453-4057qib7 5365 4 of of IN cord-005453-4057qib7 5365 5 thrombomodulin thrombomodulin NN cord-005453-4057qib7 5365 6 gene gene NN cord-005453-4057qib7 5365 7 polymorphisms polymorphism NNS cord-005453-4057qib7 5365 8 after after IN cord-005453-4057qib7 5365 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 5365 10 stem stem NN cord-005453-4057qib7 5365 11 cell cell NN cord-005453-4057qib7 5365 12 transplantation transplantation NN cord-005453-4057qib7 5365 13 Background background NN cord-005453-4057qib7 5365 14 : : : cord-005453-4057qib7 5365 15 Chronic chronic JJ cord-005453-4057qib7 5365 16 graft graft NN cord-005453-4057qib7 5365 17 - - HYPH cord-005453-4057qib7 5365 18 versus versus IN cord-005453-4057qib7 5365 19 - - HYPH cord-005453-4057qib7 5365 20 host host NN cord-005453-4057qib7 5365 21 disease disease NN cord-005453-4057qib7 5365 22 ( ( -LRB- cord-005453-4057qib7 5365 23 cGVHD cGVHD NNP cord-005453-4057qib7 5365 24 ) ) -RRB- cord-005453-4057qib7 5365 25 remains remain VBZ cord-005453-4057qib7 5365 26 the the DT cord-005453-4057qib7 5365 27 major major JJ cord-005453-4057qib7 5365 28 cause cause NN cord-005453-4057qib7 5365 29 of of IN cord-005453-4057qib7 5365 30 late late JJ cord-005453-4057qib7 5365 31 morbidity morbidity NN cord-005453-4057qib7 5365 32 and and CC cord-005453-4057qib7 5365 33 mortality mortality NN cord-005453-4057qib7 5365 34 after after IN cord-005453-4057qib7 5365 35 allogeneic allogeneic NN cord-005453-4057qib7 5365 36 blood blood NN cord-005453-4057qib7 5365 37 and and CC cord-005453-4057qib7 5365 38 marrow marrow NN cord-005453-4057qib7 5365 39 transplantation transplantation NN cord-005453-4057qib7 5365 40 . . . cord-005453-4057qib7 5366 1 Treatment treatment NN cord-005453-4057qib7 5366 2 options option NNS cord-005453-4057qib7 5366 3 for for IN cord-005453-4057qib7 5366 4 cGVHD cGVHD NNP cord-005453-4057qib7 5366 5 , , , cord-005453-4057qib7 5366 6 particularly particularly RB cord-005453-4057qib7 5366 7 its -PRON- PRP$ cord-005453-4057qib7 5366 8 sclerotic sclerotic JJ cord-005453-4057qib7 5366 9 forms form NNS cord-005453-4057qib7 5366 10 remain remain VBP cord-005453-4057qib7 5366 11 limited limited JJ cord-005453-4057qib7 5366 12 . . . cord-005453-4057qib7 5367 1 Active active JJ cord-005453-4057qib7 5367 2 Hedgehog Hedgehog NNP cord-005453-4057qib7 5367 3 ( ( -LRB- cord-005453-4057qib7 5367 4 Hh Hh NNP cord-005453-4057qib7 5367 5 ) ) -RRB- cord-005453-4057qib7 5367 6 signaling signaling NN cord-005453-4057qib7 5367 7 was be VBD cord-005453-4057qib7 5367 8 shown show VBN cord-005453-4057qib7 5367 9 as as IN cord-005453-4057qib7 5367 10 a a DT cord-005453-4057qib7 5367 11 therapeutic therapeutic JJ cord-005453-4057qib7 5367 12 target target NN cord-005453-4057qib7 5367 13 in in IN cord-005453-4057qib7 5367 14 both both DT cord-005453-4057qib7 5367 15 mouse mouse NN cord-005453-4057qib7 5367 16 and and CC cord-005453-4057qib7 5367 17 human human JJ cord-005453-4057qib7 5367 18 cGVHD cgvhd NN cord-005453-4057qib7 5367 19 , , , cord-005453-4057qib7 5367 20 with with IN cord-005453-4057qib7 5367 21 limited limited JJ cord-005453-4057qib7 5367 22 efficacy efficacy NN cord-005453-4057qib7 5367 23 and and CC cord-005453-4057qib7 5367 24 significant significant JJ cord-005453-4057qib7 5367 25 toxicities toxicity NNS cord-005453-4057qib7 5367 26 described describe VBN cord-005453-4057qib7 5367 27 in in IN cord-005453-4057qib7 5367 28 a a DT cord-005453-4057qib7 5367 29 published publish VBN cord-005453-4057qib7 5367 30 clinical clinical JJ cord-005453-4057qib7 5367 31 trial trial NN cord-005453-4057qib7 5367 32 ( ( -LRB- cord-005453-4057qib7 5367 33 DeFilipp DeFilipp NNP cord-005453-4057qib7 5367 34 , , , cord-005453-4057qib7 5367 35 2017 2017 CD cord-005453-4057qib7 5367 36 ) ) -RRB- cord-005453-4057qib7 5367 37 . . . cord-005453-4057qib7 5368 1 Methods method NNS cord-005453-4057qib7 5368 2 : : : cord-005453-4057qib7 5368 3 Adult adult NN cord-005453-4057qib7 5368 4 patients patient NNS cord-005453-4057qib7 5368 5 with with IN cord-005453-4057qib7 5368 6 steroid steroid NN cord-005453-4057qib7 5368 7 refractory refractory JJ cord-005453-4057qib7 5368 8 sclerodermatous sclerodermatous JJ cord-005453-4057qib7 5368 9 cGVHD cGVHD NNP cord-005453-4057qib7 5368 10 , , , cord-005453-4057qib7 5368 11 defined define VBN cord-005453-4057qib7 5368 12 as as IN cord-005453-4057qib7 5368 13 requiring require VBG cord-005453-4057qib7 5368 14 > > XX cord-005453-4057qib7 5369 1 0.5 0.5 CD cord-005453-4057qib7 5369 2 mg mg NNP cord-005453-4057qib7 5369 3 / / SYM cord-005453-4057qib7 5369 4 kg kg NNP cord-005453-4057qib7 5369 5 / / SYM cord-005453-4057qib7 5369 6 day day NN cord-005453-4057qib7 5369 7 of of IN cord-005453-4057qib7 5369 8 prednisone prednisone NNP cord-005453-4057qib7 5369 9 dose dose NN cord-005453-4057qib7 5369 10 equivalent equivalent NN cord-005453-4057qib7 5369 11 ( ( -LRB- cord-005453-4057qib7 5369 12 PDE PDE NNP cord-005453-4057qib7 5369 13 ) ) -RRB- cord-005453-4057qib7 5369 14 , , , cord-005453-4057qib7 5369 15 or or CC cord-005453-4057qib7 5369 16 need need VB cord-005453-4057qib7 5369 17 for for IN cord-005453-4057qib7 5369 18 second second JJ cord-005453-4057qib7 5369 19 - - HYPH cord-005453-4057qib7 5369 20 or or CC cord-005453-4057qib7 5369 21 third third JJ cord-005453-4057qib7 5369 22 - - HYPH cord-005453-4057qib7 5369 23 line line NN cord-005453-4057qib7 5369 24 therapy therapy NN cord-005453-4057qib7 5369 25 beyond beyond IN cord-005453-4057qib7 5369 26 corticosteroids corticosteroid NNS cord-005453-4057qib7 5369 27 and and CC cord-005453-4057qib7 5369 28 calcineurin calcineurin NN cord-005453-4057qib7 5369 29 inhibitors inhibitor NNS cord-005453-4057qib7 5369 30 or or CC cord-005453-4057qib7 5369 31 sirolimus sirolimus NNP cord-005453-4057qib7 5369 32 were be VBD cord-005453-4057qib7 5369 33 eligible eligible JJ cord-005453-4057qib7 5369 34 for for IN cord-005453-4057qib7 5369 35 this this DT cord-005453-4057qib7 5369 36 open open JJ cord-005453-4057qib7 5369 37 label label NN cord-005453-4057qib7 5369 38 study study NN cord-005453-4057qib7 5369 39 of of IN cord-005453-4057qib7 5369 40 vismodegib vismodegib NNP cord-005453-4057qib7 5369 41 , , , cord-005453-4057qib7 5369 42 a a DT cord-005453-4057qib7 5369 43 first first JJ cord-005453-4057qib7 5369 44 generation generation NN cord-005453-4057qib7 5369 45 Hh Hh NNP cord-005453-4057qib7 5369 46 pathway pathway NN cord-005453-4057qib7 5369 47 inhibitor inhibitor NN cord-005453-4057qib7 5369 48 . . . cord-005453-4057qib7 5370 1 Primary primary JJ cord-005453-4057qib7 5370 2 endpoint endpoint NN cord-005453-4057qib7 5370 3 was be VBD cord-005453-4057qib7 5370 4 failure failure NN cord-005453-4057qib7 5370 5 free free JJ cord-005453-4057qib7 5370 6 survival survival NN cord-005453-4057qib7 5370 7 , , , cord-005453-4057qib7 5370 8 defined define VBN cord-005453-4057qib7 5370 9 as as IN cord-005453-4057qib7 5370 10 absence absence NN cord-005453-4057qib7 5370 11 of of IN cord-005453-4057qib7 5370 12 non non JJ cord-005453-4057qib7 5370 13 - - JJ cord-005453-4057qib7 5370 14 relapse relapse JJ cord-005453-4057qib7 5370 15 mortality mortality NN cord-005453-4057qib7 5370 16 , , , cord-005453-4057qib7 5370 17 no no DT cord-005453-4057qib7 5370 18 recurrent recurrent JJ cord-005453-4057qib7 5370 19 malignancy malignancy NN cord-005453-4057qib7 5370 20 , , , cord-005453-4057qib7 5370 21 steroid steroid NN cord-005453-4057qib7 5370 22 dose dose NN cord-005453-4057qib7 5370 23 at at IN cord-005453-4057qib7 5370 24 6 6 CD cord-005453-4057qib7 5370 25 months month NNS cord-005453-4057qib7 5370 26 = = NFP cord-005453-4057qib7 5371 1 < < XX cord-005453-4057qib7 5371 2 0.2 0.2 CD cord-005453-4057qib7 5371 3 mg mg NNP cord-005453-4057qib7 5371 4 / / SYM cord-005453-4057qib7 5371 5 kg kg NNP cord-005453-4057qib7 5371 6 / / SYM cord-005453-4057qib7 5371 7 day day NN cord-005453-4057qib7 5371 8 of of IN cord-005453-4057qib7 5371 9 PDE PDE NNP cord-005453-4057qib7 5371 10 , , , cord-005453-4057qib7 5371 11 and and CC cord-005453-4057qib7 5371 12 no no DT cord-005453-4057qib7 5371 13 addition addition NN cord-005453-4057qib7 5371 14 of of IN cord-005453-4057qib7 5371 15 new new JJ cord-005453-4057qib7 5371 16 systemic systemic JJ cord-005453-4057qib7 5371 17 treatment treatment NN cord-005453-4057qib7 5371 18 . . . cord-005453-4057qib7 5372 1 Vismodegib Vismodegib NNP cord-005453-4057qib7 5372 2 was be VBD cord-005453-4057qib7 5372 3 administered administer VBN cord-005453-4057qib7 5372 4 orally orally RB cord-005453-4057qib7 5372 5 for for IN cord-005453-4057qib7 5372 6 6 6 CD cord-005453-4057qib7 5372 7 - - SYM cord-005453-4057qib7 5372 8 12 12 CD cord-005453-4057qib7 5372 9 months month NNS cord-005453-4057qib7 5372 10 , , , cord-005453-4057qib7 5372 11 with with IN cord-005453-4057qib7 5372 12 dose dose JJ cord-005453-4057qib7 5372 13 reductions reduction NNS cord-005453-4057qib7 5372 14 at at IN cord-005453-4057qib7 5372 15 development development NN cord-005453-4057qib7 5372 16 of of IN cord-005453-4057qib7 5372 17 toxicities toxicity NNS cord-005453-4057qib7 5372 18 . . . cord-005453-4057qib7 5373 1 Peripheral peripheral JJ cord-005453-4057qib7 5373 2 blood blood NN cord-005453-4057qib7 5373 3 mononuclear mononuclear NN cord-005453-4057qib7 5373 4 cells cell NNS cord-005453-4057qib7 5373 5 were be VBD cord-005453-4057qib7 5373 6 isolated isolate VBN cord-005453-4057qib7 5373 7 from from IN cord-005453-4057qib7 5373 8 samples sample NNS cord-005453-4057qib7 5373 9 collected collect VBN cord-005453-4057qib7 5373 10 at at IN cord-005453-4057qib7 5373 11 treatment treatment NN cord-005453-4057qib7 5373 12 initiation initiation NN cord-005453-4057qib7 5373 13 and and CC cord-005453-4057qib7 5373 14 every every DT cord-005453-4057qib7 5373 15 three three CD cord-005453-4057qib7 5373 16 months month NNS cord-005453-4057qib7 5373 17 thereafter thereafter RB cord-005453-4057qib7 5373 18 . . . cord-005453-4057qib7 5374 1 The the DT cord-005453-4057qib7 5374 2 immune immune JJ cord-005453-4057qib7 5374 3 profile profile NN cord-005453-4057qib7 5374 4 of of IN cord-005453-4057qib7 5374 5 circulating circulate VBG cord-005453-4057qib7 5374 6 B b NN cord-005453-4057qib7 5374 7 cells cell NNS cord-005453-4057qib7 5374 8 was be VBD cord-005453-4057qib7 5374 9 analyzed analyze VBN cord-005453-4057qib7 5374 10 by by IN cord-005453-4057qib7 5374 11 flow flow NN cord-005453-4057qib7 5374 12 cytometry cytometry NN cord-005453-4057qib7 5374 13 and and CC cord-005453-4057qib7 5374 14 T t NN cord-005453-4057qib7 5374 15 helper helper NN cord-005453-4057qib7 5374 16 polarization polarization NN cord-005453-4057qib7 5374 17 by by IN cord-005453-4057qib7 5374 18 qRT qRT NNP cord-005453-4057qib7 5374 19 - - HYPH cord-005453-4057qib7 5374 20 PCR PCR NNP cord-005453-4057qib7 5374 21 of of IN cord-005453-4057qib7 5374 22 sortpurified sortpurifie VBN cord-005453-4057qib7 5374 23 CD4 CD4 NNP cord-005453-4057qib7 5374 24 + + CC cord-005453-4057qib7 5374 25 T t NN cord-005453-4057qib7 5374 26 cells cell NNS cord-005453-4057qib7 5374 27 . . . cord-005453-4057qib7 5375 1 Results result NNS cord-005453-4057qib7 5375 2 : : : cord-005453-4057qib7 5376 1 At at IN cord-005453-4057qib7 5376 2 the the DT cord-005453-4057qib7 5376 3 time time NN cord-005453-4057qib7 5376 4 of of IN cord-005453-4057qib7 5376 5 interim interim JJ cord-005453-4057qib7 5376 6 analysis analysis NN cord-005453-4057qib7 5376 7 , , , cord-005453-4057qib7 5376 8 6 6 CD cord-005453-4057qib7 5376 9 patients patient NNS cord-005453-4057qib7 5376 10 were be VBD cord-005453-4057qib7 5376 11 evaluated evaluate VBN cord-005453-4057qib7 5376 12 . . . cord-005453-4057qib7 5377 1 3 3 CD cord-005453-4057qib7 5377 2 patients patient NNS cord-005453-4057qib7 5377 3 completed complete VBN cord-005453-4057qib7 5377 4 6 6 CD cord-005453-4057qib7 5377 5 months month NNS cord-005453-4057qib7 5377 6 of of IN cord-005453-4057qib7 5377 7 treatment treatment NN cord-005453-4057qib7 5377 8 and and CC cord-005453-4057qib7 5377 9 five five CD cord-005453-4057qib7 5377 10 patients patient NNS cord-005453-4057qib7 5377 11 completed complete VBN cord-005453-4057qib7 5377 12 3 3 CD cord-005453-4057qib7 5377 13 months month NNS cord-005453-4057qib7 5377 14 of of IN cord-005453-4057qib7 5377 15 treatment treatment NN cord-005453-4057qib7 5377 16 . . . cord-005453-4057qib7 5378 1 Therapy therapy NN cord-005453-4057qib7 5378 2 was be VBD cord-005453-4057qib7 5378 3 discontinued discontinue VBN cord-005453-4057qib7 5378 4 in in IN cord-005453-4057qib7 5378 5 3 3 CD cord-005453-4057qib7 5378 6 patients patient NNS cord-005453-4057qib7 5378 7 prior prior RB cord-005453-4057qib7 5378 8 to to IN cord-005453-4057qib7 5378 9 6 6 CD cord-005453-4057qib7 5378 10 months month NNS cord-005453-4057qib7 5378 11 due due JJ cord-005453-4057qib7 5378 12 to to IN cord-005453-4057qib7 5378 13 treatment treatment NN cord-005453-4057qib7 5378 14 - - HYPH cord-005453-4057qib7 5378 15 related relate VBN cord-005453-4057qib7 5378 16 ( ( -LRB- cord-005453-4057qib7 5378 17 n=2 n=2 NNS cord-005453-4057qib7 5378 18 ) ) -RRB- cord-005453-4057qib7 5378 19 and and CC cord-005453-4057qib7 5378 20 unrelated unrelated JJ cord-005453-4057qib7 5378 21 ( ( -LRB- cord-005453-4057qib7 5378 22 n=1 n=1 JJ cord-005453-4057qib7 5378 23 ) ) -RRB- cord-005453-4057qib7 5378 24 side side NN cord-005453-4057qib7 5378 25 effects effect NNS cord-005453-4057qib7 5378 26 . . . cord-005453-4057qib7 5379 1 Most Most JJS cord-005453-4057qib7 5379 2 patients patient NNS cord-005453-4057qib7 5379 3 experienced experience VBD cord-005453-4057qib7 5379 4 grade grade NN cord-005453-4057qib7 5379 5 2 2 CD cord-005453-4057qib7 5379 6 toxicities toxicity NNS cord-005453-4057qib7 5379 7 ( ( -LRB- cord-005453-4057qib7 5379 8 muscle muscle NN cord-005453-4057qib7 5379 9 cramps cramp NNS cord-005453-4057qib7 5379 10 and and CC cord-005453-4057qib7 5379 11 dysgeusia dysgeusia NNP cord-005453-4057qib7 5379 12 ) ) -RRB- cord-005453-4057qib7 5379 13 , , , cord-005453-4057qib7 5379 14 with with IN cord-005453-4057qib7 5379 15 only only RB cord-005453-4057qib7 5379 16 a a DT cord-005453-4057qib7 5379 17 single single JJ cord-005453-4057qib7 5379 18 grade grade NN cord-005453-4057qib7 5379 19 3 3 CD cord-005453-4057qib7 5379 20 toxicity toxicity NN cord-005453-4057qib7 5379 21 ( ( -LRB- cord-005453-4057qib7 5379 22 weight weight NN cord-005453-4057qib7 5379 23 loss loss NN cord-005453-4057qib7 5379 24 ) ) -RRB- cord-005453-4057qib7 5379 25 . . . cord-005453-4057qib7 5380 1 5 5 CD cord-005453-4057qib7 5380 2 patients patient NNS cord-005453-4057qib7 5380 3 who who WP cord-005453-4057qib7 5380 4 completed complete VBD cord-005453-4057qib7 5380 5 3 3 CD cord-005453-4057qib7 5380 6 months month NNS cord-005453-4057qib7 5380 7 of of IN cord-005453-4057qib7 5380 8 therapy therapy NN cord-005453-4057qib7 5380 9 demonstrated demonstrate VBD cord-005453-4057qib7 5380 10 partial partial JJ cord-005453-4057qib7 5380 11 response response NN cord-005453-4057qib7 5380 12 , , , cord-005453-4057qib7 5380 13 and and CC cord-005453-4057qib7 5380 14 overall overall RB cord-005453-4057qib7 5380 15 , , , cord-005453-4057qib7 5380 16 the the DT cord-005453-4057qib7 5380 17 primary primary JJ cord-005453-4057qib7 5380 18 endpoint endpoint NN cord-005453-4057qib7 5380 19 was be VBD cord-005453-4057qib7 5380 20 reached reach VBN cord-005453-4057qib7 5380 21 in in IN cord-005453-4057qib7 5380 22 50 50 CD cord-005453-4057qib7 5380 23 % % NN cord-005453-4057qib7 5380 24 ( ( -LRB- cord-005453-4057qib7 5380 25 3/6 3/6 CD cord-005453-4057qib7 5380 26 ) ) -RRB- cord-005453-4057qib7 5380 27 of of IN cord-005453-4057qib7 5380 28 patients patient NNS cord-005453-4057qib7 5380 29 . . . cord-005453-4057qib7 5381 1 In in IN cord-005453-4057qib7 5381 2 2 2 CD cord-005453-4057qib7 5381 3 patients patient NNS cord-005453-4057qib7 5381 4 who who WP cord-005453-4057qib7 5381 5 discontinued discontinue VBD cord-005453-4057qib7 5381 6 vismodegib vismodegib NNP cord-005453-4057qib7 5381 7 , , , cord-005453-4057qib7 5381 8 cGVHD cGVHD NNP cord-005453-4057qib7 5381 9 worsened worsen VBD cord-005453-4057qib7 5381 10 acutely acutely RB cord-005453-4057qib7 5381 11 after after IN cord-005453-4057qib7 5381 12 discontinuation discontinuation NN cord-005453-4057qib7 5381 13 . . . cord-005453-4057qib7 5382 1 Correlative correlative JJ cord-005453-4057qib7 5382 2 analysis analysis NN cord-005453-4057qib7 5382 3 of of IN cord-005453-4057qib7 5382 4 immune immune JJ cord-005453-4057qib7 5382 5 cellular cellular JJ cord-005453-4057qib7 5382 6 subsets subset NNS cord-005453-4057qib7 5382 7 in in IN cord-005453-4057qib7 5382 8 peripheral peripheral JJ cord-005453-4057qib7 5382 9 blood blood NN cord-005453-4057qib7 5382 10 in in IN cord-005453-4057qib7 5382 11 4 4 CD cord-005453-4057qib7 5382 12 paired pair VBN cord-005453-4057qib7 5382 13 samples sample NNS cord-005453-4057qib7 5382 14 ( ( -LRB- cord-005453-4057qib7 5382 15 pre pre JJ cord-005453-4057qib7 5382 16 - - JJ cord-005453-4057qib7 5382 17 treatment treatment NN cord-005453-4057qib7 5382 18 and and CC cord-005453-4057qib7 5382 19 month month NN cord-005453-4057qib7 5382 20 3 3 CD cord-005453-4057qib7 5382 21 of of IN cord-005453-4057qib7 5382 22 therapy therapy NN cord-005453-4057qib7 5382 23 ) ) -RRB- cord-005453-4057qib7 5382 24 documented document VBD cord-005453-4057qib7 5382 25 modulation modulation NN cord-005453-4057qib7 5382 26 of of IN cord-005453-4057qib7 5382 27 B b NN cord-005453-4057qib7 5382 28 cell cell NN cord-005453-4057qib7 5382 29 subsets subset NNS cord-005453-4057qib7 5382 30 pathogenic pathogenic JJ cord-005453-4057qib7 5382 31 in in IN cord-005453-4057qib7 5382 32 cGVHD cGVHD NNP cord-005453-4057qib7 5383 1 ( ( -LRB- cord-005453-4057qib7 5383 2 pregerminal pregerminal NNP cord-005453-4057qib7 5383 3 center center NNP cord-005453-4057qib7 5383 4 and and CC cord-005453-4057qib7 5383 5 plasmablast plasmablast NN cord-005453-4057qib7 5383 6 - - HYPH cord-005453-4057qib7 5383 7 like like JJ cord-005453-4057qib7 5383 8 B b NN cord-005453-4057qib7 5383 9 cells cell NNS cord-005453-4057qib7 5383 10 ) ) -RRB- cord-005453-4057qib7 5383 11 and and CC cord-005453-4057qib7 5383 12 diminished diminish VBD cord-005453-4057qib7 5383 13 T T NNP cord-005453-4057qib7 5383 14 helper helper NN cord-005453-4057qib7 5383 15 2 2 CD cord-005453-4057qib7 5383 16 polarization polarization NN cord-005453-4057qib7 5383 17 in in IN cord-005453-4057qib7 5383 18 CD4 CD4 NNP cord-005453-4057qib7 5383 19 T T NNP cord-005453-4057qib7 5383 20 cells cell NNS cord-005453-4057qib7 5383 21 . . . cord-005453-4057qib7 5384 1 Conclusions conclusion NNS cord-005453-4057qib7 5384 2 : : : cord-005453-4057qib7 5385 1 Overall overall RB cord-005453-4057qib7 5385 2 , , , cord-005453-4057qib7 5385 3 use use NN cord-005453-4057qib7 5385 4 of of IN cord-005453-4057qib7 5385 5 vismodegib vismodegib NNP cord-005453-4057qib7 5385 6 was be VBD cord-005453-4057qib7 5385 7 associated associate VBN cord-005453-4057qib7 5385 8 with with IN cord-005453-4057qib7 5385 9 potential potential JJ cord-005453-4057qib7 5385 10 clinical clinical JJ cord-005453-4057qib7 5385 11 efficacy efficacy NN cord-005453-4057qib7 5385 12 in in IN cord-005453-4057qib7 5385 13 sclerodermatous sclerodermatous JJ cord-005453-4057qib7 5385 14 cGVHD cGVHD NNP cord-005453-4057qib7 5385 15 with with IN cord-005453-4057qib7 5385 16 possible possible JJ cord-005453-4057qib7 5385 17 mechanistic mechanistic JJ cord-005453-4057qib7 5385 18 evidence evidence NN cord-005453-4057qib7 5385 19 arising arise VBG cord-005453-4057qib7 5385 20 in in IN cord-005453-4057qib7 5385 21 correlative correlative JJ cord-005453-4057qib7 5385 22 studies study NNS cord-005453-4057qib7 5385 23 . . . cord-005453-4057qib7 5386 1 While while IN cord-005453-4057qib7 5386 2 side side NN cord-005453-4057qib7 5386 3 effects effect NNS cord-005453-4057qib7 5386 4 were be VBD cord-005453-4057qib7 5386 5 common common JJ cord-005453-4057qib7 5386 6 , , , cord-005453-4057qib7 5386 7 further further JJ cord-005453-4057qib7 5386 8 studies study NNS cord-005453-4057qib7 5386 9 of of IN cord-005453-4057qib7 5386 10 Hh Hh NNP cord-005453-4057qib7 5386 11 inhibition inhibition NN cord-005453-4057qib7 5386 12 in in IN cord-005453-4057qib7 5386 13 cGVHD cGVHD NNP cord-005453-4057qib7 5386 14 are be VBP cord-005453-4057qib7 5386 15 warranted warrant VBN cord-005453-4057qib7 5386 16 . . . cord-005453-4057qib7 5387 1 Future future JJ cord-005453-4057qib7 5387 2 studies study NNS cord-005453-4057qib7 5387 3 should should MD cord-005453-4057qib7 5387 4 employ employ VB cord-005453-4057qib7 5387 5 adjusted adjust VBN cord-005453-4057qib7 5387 6 dosing dose VBG cord-005453-4057qib7 5387 7 regimens regimen NNS cord-005453-4057qib7 5387 8 , , , cord-005453-4057qib7 5387 9 along along IN cord-005453-4057qib7 5387 10 with with IN cord-005453-4057qib7 5387 11 supportive supportive JJ cord-005453-4057qib7 5387 12 care care NN cord-005453-4057qib7 5387 13 interventions intervention NNS cord-005453-4057qib7 5387 14 to to TO cord-005453-4057qib7 5387 15 offset offset VB cord-005453-4057qib7 5387 16 side side NN cord-005453-4057qib7 5387 17 effects effect NNS cord-005453-4057qib7 5387 18 , , , cord-005453-4057qib7 5387 19 and and CC cord-005453-4057qib7 5387 20 testing testing NN cord-005453-4057qib7 5387 21 of of IN cord-005453-4057qib7 5387 22 novel novel NN cord-005453-4057qib7 5387 23 Hh Hh NNP cord-005453-4057qib7 5387 24 inhibitors inhibitor NNS cord-005453-4057qib7 5387 25 with with IN cord-005453-4057qib7 5387 26 enhanced enhanced JJ cord-005453-4057qib7 5387 27 safety safety NN cord-005453-4057qib7 5387 28 profiles profile NNS cord-005453-4057qib7 5387 29 . . . cord-005453-4057qib7 5388 1 Clinical clinical JJ cord-005453-4057qib7 5388 2 Background background NN cord-005453-4057qib7 5388 3 : : : cord-005453-4057qib7 5388 4 Graft graft NN cord-005453-4057qib7 5388 5 - - HYPH cord-005453-4057qib7 5388 6 versus versus IN cord-005453-4057qib7 5388 7 - - HYPH cord-005453-4057qib7 5388 8 host host NN cord-005453-4057qib7 5388 9 disease disease NN cord-005453-4057qib7 5388 10 ( ( -LRB- cord-005453-4057qib7 5388 11 GVHD GVHD NNP cord-005453-4057qib7 5388 12 ) ) -RRB- cord-005453-4057qib7 5388 13 results result VBZ cord-005453-4057qib7 5388 14 from from IN cord-005453-4057qib7 5388 15 recognition recognition NN cord-005453-4057qib7 5388 16 of of IN cord-005453-4057qib7 5388 17 host host NN cord-005453-4057qib7 5388 18 antigens antigen NNS cord-005453-4057qib7 5388 19 by by IN cord-005453-4057qib7 5388 20 donor donor NN cord-005453-4057qib7 5388 21 T t NN cord-005453-4057qib7 5388 22 cells cell NNS cord-005453-4057qib7 5388 23 following follow VBG cord-005453-4057qib7 5388 24 allogeneic allogeneic NN cord-005453-4057qib7 5388 25 hematopoietic hematopoietic JJ cord-005453-4057qib7 5388 26 stem stem NN cord-005453-4057qib7 5388 27 cell cell NN cord-005453-4057qib7 5388 28 transplantation transplantation NN cord-005453-4057qib7 5388 29 ( ( -LRB- cord-005453-4057qib7 5388 30 SCT SCT NNP cord-005453-4057qib7 5388 31 ) ) -RRB- cord-005453-4057qib7 5388 32 . . . cord-005453-4057qib7 5389 1 We -PRON- PRP cord-005453-4057qib7 5389 2 tested test VBD cord-005453-4057qib7 5389 3 the the DT cord-005453-4057qib7 5389 4 hypothesis hypothesis NN cord-005453-4057qib7 5389 5 that that IN cord-005453-4057qib7 5389 6 somatic somatic JJ cord-005453-4057qib7 5389 7 neomutations neomutation NNS cord-005453-4057qib7 5389 8 occurring occur VBG cord-005453-4057qib7 5389 9 after after IN cord-005453-4057qib7 5389 10 SCT SCT NNP cord-005453-4057qib7 5389 11 from from IN cord-005453-4057qib7 5389 12 donor donor NN cord-005453-4057qib7 5389 13 and/or and/or CC cord-005453-4057qib7 5389 14 recipient recipient NN cord-005453-4057qib7 5389 15 DNA DNA NNP cord-005453-4057qib7 5389 16 may may MD cord-005453-4057qib7 5389 17 trigger trigger VB cord-005453-4057qib7 5389 18 GVHD GVHD NNP cord-005453-4057qib7 5389 19 . . . cord-005453-4057qib7 5390 1 Methods method NNS cord-005453-4057qib7 5390 2 : : : cord-005453-4057qib7 5390 3 We -PRON- PRP cord-005453-4057qib7 5390 4 longitudinally longitudinally RB cord-005453-4057qib7 5390 5 analyzed analyze VBD cord-005453-4057qib7 5390 6 both both CC cord-005453-4057qib7 5390 7 constitutive constitutive JJ cord-005453-4057qib7 5390 8 and and CC cord-005453-4057qib7 5390 9 somatic somatic JJ cord-005453-4057qib7 5390 10 mutations mutation NNS cord-005453-4057qib7 5390 11 by by IN cord-005453-4057qib7 5390 12 whole whole JJ cord-005453-4057qib7 5390 13 exome exome NN cord-005453-4057qib7 5390 14 sequencing sequencing NN cord-005453-4057qib7 5390 15 ( ( -LRB- cord-005453-4057qib7 5390 16 WES WES NNP cord-005453-4057qib7 5390 17 ) ) -RRB- cord-005453-4057qib7 5390 18 in in IN cord-005453-4057qib7 5390 19 2 2 CD cord-005453-4057qib7 5390 20 patients patient NNS cord-005453-4057qib7 5390 21 who who WP cord-005453-4057qib7 5390 22 received receive VBD cord-005453-4057qib7 5390 23 SCT SCT NNP cord-005453-4057qib7 5390 24 from from IN cord-005453-4057qib7 5390 25 a a DT cord-005453-4057qib7 5390 26 sex sex NN cord-005453-4057qib7 5390 27 - - HYPH cord-005453-4057qib7 5390 28 matched match VBN cord-005453-4057qib7 5390 29 HLAidentical hlaidentical JJ cord-005453-4057qib7 5390 30 sibling sibling NN cord-005453-4057qib7 5390 31 for for IN cord-005453-4057qib7 5390 32 NPM1 NPM1 NNP cord-005453-4057qib7 5390 33 mutated mutated JJ cord-005453-4057qib7 5390 34 acute acute JJ cord-005453-4057qib7 5390 35 myeloid myeloid NN cord-005453-4057qib7 5390 36 leukemia leukemia NN cord-005453-4057qib7 5390 37 ( ( -LRB- cord-005453-4057qib7 5390 38 Pt#1 pt#1 NN cord-005453-4057qib7 5390 39 ) ) -RRB- cord-005453-4057qib7 5390 40 and and CC cord-005453-4057qib7 5390 41 JAK2 JAK2 NNP cord-005453-4057qib7 5390 42 V617F v617f RB cord-005453-4057qib7 5390 43 mutated mutate VBD cord-005453-4057qib7 5390 44 primary primary JJ cord-005453-4057qib7 5390 45 myelofibrosis myelofibrosis NN cord-005453-4057qib7 5390 46 ( ( -LRB- cord-005453-4057qib7 5390 47 Pt#2 pt#2 CD cord-005453-4057qib7 5390 48 ) ) -RRB- cord-005453-4057qib7 5390 49 . . . cord-005453-4057qib7 5391 1 Both both DT cord-005453-4057qib7 5391 2 patients patient NNS cord-005453-4057qib7 5391 3 were be VBD cord-005453-4057qib7 5391 4 initially initially RB cord-005453-4057qib7 5391 5 refractory refractory JJ cord-005453-4057qib7 5391 6 to to IN cord-005453-4057qib7 5391 7 alloreactivity alloreactivity NN cord-005453-4057qib7 5391 8 , , , cord-005453-4057qib7 5391 9 i.e. i.e. FW cord-005453-4057qib7 5391 10 not not RB cord-005453-4057qib7 5391 11 displaying display VBG cord-005453-4057qib7 5391 12 any any DT cord-005453-4057qib7 5391 13 signs sign NNS cord-005453-4057qib7 5391 14 of of IN cord-005453-4057qib7 5391 15 GVHD GVHD NNP cord-005453-4057qib7 5391 16 , , , cord-005453-4057qib7 5391 17 even even RB cord-005453-4057qib7 5391 18 after after IN cord-005453-4057qib7 5391 19 several several JJ cord-005453-4057qib7 5391 20 donor donor NN cord-005453-4057qib7 5391 21 lymphocyte lymphocyte NN cord-005453-4057qib7 5391 22 infusions infusion NNS cord-005453-4057qib7 5391 23 . . . cord-005453-4057qib7 5392 1 Acute acute JJ cord-005453-4057qib7 5392 2 gut gut NN cord-005453-4057qib7 5392 3 GVHD GVHD NNP cord-005453-4057qib7 5392 4 finally finally RB cord-005453-4057qib7 5392 5 occurred occur VBD cord-005453-4057qib7 5392 6 after after IN cord-005453-4057qib7 5392 7 a a DT cord-005453-4057qib7 5392 8 further further JJ cord-005453-4057qib7 5392 9 DLI DLI NNP cord-005453-4057qib7 5392 10 preceded precede VBN cord-005453-4057qib7 5392 11 by by IN cord-005453-4057qib7 5392 12 a a DT cord-005453-4057qib7 5392 13 lymphodepleting lymphodepleting NN cord-005453-4057qib7 5392 14 chemotherapy chemotherapy NN cord-005453-4057qib7 5392 15 . . . cord-005453-4057qib7 5393 1 In in IN cord-005453-4057qib7 5393 2 Pt#2 Pt#2 NNS cord-005453-4057qib7 5393 3 , , , cord-005453-4057qib7 5393 4 GVHD GVHD NNP cord-005453-4057qib7 5393 5 correlated correlate VBD cord-005453-4057qib7 5393 6 with with IN cord-005453-4057qib7 5393 7 a a DT cord-005453-4057qib7 5393 8 graft graft NN cord-005453-4057qib7 5393 9 - - HYPH cord-005453-4057qib7 5393 10 versus versus IN cord-005453-4057qib7 5393 11 - - HYPH cord-005453-4057qib7 5393 12 tumor tumor NN cord-005453-4057qib7 5393 13 effect effect NN cord-005453-4057qib7 5393 14 . . . cord-005453-4057qib7 5394 1 WES WES NNP cord-005453-4057qib7 5394 2 was be VBD cord-005453-4057qib7 5394 3 performed perform VBN cord-005453-4057qib7 5394 4 on on IN cord-005453-4057qib7 5394 5 DNA DNA NNP cord-005453-4057qib7 5394 6 from from IN cord-005453-4057qib7 5394 7 recipient recipient NN cord-005453-4057qib7 5394 8 saliva saliva NN cord-005453-4057qib7 5394 9 and and CC cord-005453-4057qib7 5394 10 donor donor NN cord-005453-4057qib7 5394 11 PBMCs pbmc NNS cord-005453-4057qib7 5394 12 ( ( -LRB- cord-005453-4057qib7 5394 13 germline germline JJ cord-005453-4057qib7 5394 14 samples sample NNS cord-005453-4057qib7 5394 15 ) ) -RRB- cord-005453-4057qib7 5394 16 and and CC cord-005453-4057qib7 5394 17 from from IN cord-005453-4057qib7 5394 18 sequential sequential JJ cord-005453-4057qib7 5394 19 post post JJ cord-005453-4057qib7 5394 20 - - JJ cord-005453-4057qib7 5394 21 SCT sct JJ cord-005453-4057qib7 5394 22 PBMCs pbmcs JJ cord-005453-4057qib7 5394 23 samples sample VBZ cord-005453-4057qib7 5394 24 on on IN cord-005453-4057qib7 5394 25 a a DT cord-005453-4057qib7 5394 26 HiSeq2500 HiSeq2500 NNP cord-005453-4057qib7 5394 27 Illumina Illumina NNP cord-005453-4057qib7 5394 28 with with IN cord-005453-4057qib7 5394 29 2x100bp 2x100bp CD cord-005453-4057qib7 5394 30 paired pair VBN cord-005453-4057qib7 5394 31 - - HYPH cord-005453-4057qib7 5394 32 end end NN cord-005453-4057qib7 5394 33 reads read VBZ cord-005453-4057qib7 5394 34 at at IN cord-005453-4057qib7 5394 35 a a DT cord-005453-4057qib7 5394 36 mean mean JJ cord-005453-4057qib7 5394 37 depth depth NN cord-005453-4057qib7 5394 38 of of IN cord-005453-4057qib7 5394 39 coverage coverage NN cord-005453-4057qib7 5394 40 of of IN cord-005453-4057qib7 5394 41 190 190 CD cord-005453-4057qib7 5394 42 - - HYPH cord-005453-4057qib7 5394 43 210X. 210x. CD cord-005453-4057qib7 5394 44 Germline Germline NNP cord-005453-4057qib7 5394 45 and and CC cord-005453-4057qib7 5394 46 somatic somatic JJ cord-005453-4057qib7 5394 47 mutations mutation NNS cord-005453-4057qib7 5394 48 were be VBD cord-005453-4057qib7 5394 49 determined determine VBN cord-005453-4057qib7 5394 50 using use VBG cord-005453-4057qib7 5394 51 in in IN cord-005453-4057qib7 5394 52 - - HYPH cord-005453-4057qib7 5394 53 house house NN cord-005453-4057qib7 5394 54 bioinformatic bioinformatic JJ cord-005453-4057qib7 5394 55 pipelines pipeline NNS cord-005453-4057qib7 5394 56 ( ( -LRB- cord-005453-4057qib7 5394 57 named name VBN cord-005453-4057qib7 5394 58 Ewok Ewok NNP cord-005453-4057qib7 5394 59 from from IN cord-005453-4057qib7 5394 60 the the DT cord-005453-4057qib7 5394 61 Curie Curie NNP cord-005453-4057qib7 5394 62 Institute Institute NNP cord-005453-4057qib7 5394 63 and and CC cord-005453-4057qib7 5394 64 Smaug Smaug NNP cord-005453-4057qib7 5394 65 from from IN cord-005453-4057qib7 5394 66 the the DT cord-005453-4057qib7 5394 67 Henri Henri NNP cord-005453-4057qib7 5394 68 Mondor Mondor NNP cord-005453-4057qib7 5394 69 hospital hospital NN cord-005453-4057qib7 5394 70 ) ) -RRB- cord-005453-4057qib7 5394 71 , , , cord-005453-4057qib7 5394 72 using use VBG cord-005453-4057qib7 5394 73 briefly briefly RB cord-005453-4057qib7 5394 74 GATK GATK NNP cord-005453-4057qib7 5394 75 as as IN cord-005453-4057qib7 5394 76 variant variant NN cord-005453-4057qib7 5394 77 caller caller NN cord-005453-4057qib7 5394 78 for for IN cord-005453-4057qib7 5394 79 germline germline JJ cord-005453-4057qib7 5394 80 samples sample NNS cord-005453-4057qib7 5394 81 , , , cord-005453-4057qib7 5394 82 and and CC cord-005453-4057qib7 5394 83 a a DT cord-005453-4057qib7 5394 84 combination combination NN cord-005453-4057qib7 5394 85 of of IN cord-005453-4057qib7 5394 86 3 3 CD cord-005453-4057qib7 5394 87 variant variant NN cord-005453-4057qib7 5394 88 callers caller NNS cord-005453-4057qib7 5394 89 for for IN cord-005453-4057qib7 5394 90 matched match VBN cord-005453-4057qib7 5394 91 normaltumor normaltumor JJ cord-005453-4057qib7 5394 92 pairs pair NNS cord-005453-4057qib7 5394 93 . . . cord-005453-4057qib7 5395 1 We -PRON- PRP cord-005453-4057qib7 5395 2 adjusted adjust VBD cord-005453-4057qib7 5395 3 parameters parameter NNS cord-005453-4057qib7 5395 4 to to TO cord-005453-4057qib7 5395 5 detect detect VB cord-005453-4057qib7 5395 6 somatic somatic JJ cord-005453-4057qib7 5395 7 mutations mutation NNS cord-005453-4057qib7 5395 8 at at IN cord-005453-4057qib7 5395 9 a a DT cord-005453-4057qib7 5395 10 minimal minimal JJ cord-005453-4057qib7 5395 11 variant variant JJ cord-005453-4057qib7 5395 12 allelic allelic JJ cord-005453-4057qib7 5395 13 frequency frequency NN cord-005453-4057qib7 5395 14 ( ( -LRB- cord-005453-4057qib7 5395 15 VAF VAF NNP cord-005453-4057qib7 5395 16 ) ) -RRB- cord-005453-4057qib7 5395 17 of of IN cord-005453-4057qib7 5395 18 5 5 CD cord-005453-4057qib7 5395 19 % % NN cord-005453-4057qib7 5395 20 compared compare VBN cord-005453-4057qib7 5395 21 to to IN cord-005453-4057qib7 5395 22 recipient recipient NN cord-005453-4057qib7 5395 23 and and CC cord-005453-4057qib7 5395 24 donor donor NN cord-005453-4057qib7 5395 25 germline germline NN cord-005453-4057qib7 5395 26 for for IN cord-005453-4057qib7 5395 27 all all DT cord-005453-4057qib7 5395 28 variations variation NNS cord-005453-4057qib7 5395 29 ( ( -LRB- cord-005453-4057qib7 5395 30 minimal minimal JJ cord-005453-4057qib7 5395 31 coverage coverage NN cord-005453-4057qib7 5395 32 = = SYM cord-005453-4057qib7 5395 33 8X 8x CD cord-005453-4057qib7 5395 34 for for IN cord-005453-4057qib7 5395 35 germline germline NN cord-005453-4057qib7 5395 36 and and CC cord-005453-4057qib7 5395 37 5X 5x CD cord-005453-4057qib7 5395 38 for for IN cord-005453-4057qib7 5395 39 tumor tumor NN cord-005453-4057qib7 5395 40 sample sample NN cord-005453-4057qib7 5395 41 ) ) -RRB- cord-005453-4057qib7 5395 42 . . . cord-005453-4057qib7 5396 1 Results result NNS cord-005453-4057qib7 5396 2 : : : cord-005453-4057qib7 5397 1 WES WES NNP cord-005453-4057qib7 5397 2 allowed allow VBD cord-005453-4057qib7 5397 3 detecting detect VBG cord-005453-4057qib7 5397 4 somatic somatic JJ cord-005453-4057qib7 5397 5 driver driver NN cord-005453-4057qib7 5397 6 mutations mutation NNS cord-005453-4057qib7 5397 7 explaining explain VBG cord-005453-4057qib7 5397 8 AML AML NNP cord-005453-4057qib7 5397 9 and and CC cord-005453-4057qib7 5397 10 PMF PMF NNP cord-005453-4057qib7 5397 11 for for IN cord-005453-4057qib7 5397 12 both both DT cord-005453-4057qib7 5397 13 patients patient NNS cord-005453-4057qib7 5397 14 in in IN cord-005453-4057qib7 5397 15 the the DT cord-005453-4057qib7 5397 16 initial initial JJ cord-005453-4057qib7 5397 17 timepoint timepoint NN cord-005453-4057qib7 5397 18 and and CC cord-005453-4057qib7 5397 19 all all PDT cord-005453-4057qib7 5397 20 these these DT cord-005453-4057qib7 5397 21 driver driver NN cord-005453-4057qib7 5397 22 mutations mutation NNS cord-005453-4057qib7 5397 23 disappeared disappear VBD cord-005453-4057qib7 5397 24 at at IN cord-005453-4057qib7 5397 25 the the DT cord-005453-4057qib7 5397 26 following follow VBG cord-005453-4057qib7 5397 27 timepoints timepoint NNS cord-005453-4057qib7 5397 28 . . . cord-005453-4057qib7 5398 1 As as IN cord-005453-4057qib7 5398 2 expected expect VBN cord-005453-4057qib7 5398 3 , , , cord-005453-4057qib7 5398 4 the the DT cord-005453-4057qib7 5398 5 somatic somatic JJ cord-005453-4057qib7 5398 6 variant variant NN cord-005453-4057qib7 5398 7 rate rate NN cord-005453-4057qib7 5398 8 was be VBD cord-005453-4057qib7 5398 9 10x 10x CD cord-005453-4057qib7 5398 10 higher high JJR cord-005453-4057qib7 5398 11 in in IN cord-005453-4057qib7 5398 12 Pt#1 Pt#1 NNP cord-005453-4057qib7 5398 13 with with IN cord-005453-4057qib7 5398 14 AML AML NNP cord-005453-4057qib7 5398 15 than than IN cord-005453-4057qib7 5398 16 in in IN cord-005453-4057qib7 5398 17 Pt#2 Pt#2 NNS cord-005453-4057qib7 5398 18 with with IN cord-005453-4057qib7 5398 19 PMF PMF NNP cord-005453-4057qib7 5398 20 at at IN cord-005453-4057qib7 5398 21 each each DT cord-005453-4057qib7 5398 22 timepoint timepoint NN cord-005453-4057qib7 5398 23 , , , cord-005453-4057qib7 5398 24 except except IN cord-005453-4057qib7 5398 25 for for IN cord-005453-4057qib7 5398 26 the the DT cord-005453-4057qib7 5398 27 final final JJ cord-005453-4057qib7 5398 28 GVHD GVHD NNP cord-005453-4057qib7 5398 29 timepoint timepoint NN cord-005453-4057qib7 5398 30 . . . cord-005453-4057qib7 5399 1 Indeed indeed RB cord-005453-4057qib7 5399 2 , , , cord-005453-4057qib7 5399 3 at at IN cord-005453-4057qib7 5399 4 this this DT cord-005453-4057qib7 5399 5 final final JJ cord-005453-4057qib7 5399 6 point point NN cord-005453-4057qib7 5399 7 , , , cord-005453-4057qib7 5399 8 the the DT cord-005453-4057qib7 5399 9 somatic somatic JJ cord-005453-4057qib7 5399 10 variant variant NN cord-005453-4057qib7 5399 11 rate rate NN cord-005453-4057qib7 5399 12 dramatically dramatically RB cord-005453-4057qib7 5399 13 decreased decrease VBD cord-005453-4057qib7 5399 14 by by IN cord-005453-4057qib7 5399 15 80 80 CD cord-005453-4057qib7 5399 16 % % NN cord-005453-4057qib7 5399 17 as as IN cord-005453-4057qib7 5399 18 compared compare VBN cord-005453-4057qib7 5399 19 to to IN cord-005453-4057qib7 5399 20 previous previous JJ cord-005453-4057qib7 5399 21 timepoints timepoint NNS cord-005453-4057qib7 5399 22 . . . cord-005453-4057qib7 5400 1 By by IN cord-005453-4057qib7 5400 2 subtracting subtract VBG cord-005453-4057qib7 5400 3 variants variant NNS cord-005453-4057qib7 5400 4 detected detect VBD cord-005453-4057qib7 5400 5 pre pre JJ cord-005453-4057qib7 5400 6 - - JJ cord-005453-4057qib7 5400 7 and and CC cord-005453-4057qib7 5400 8 post post JJ cord-005453-4057qib7 5400 9 - - JJ cord-005453-4057qib7 5400 10 SCT sct NN cord-005453-4057qib7 5400 11 from from IN cord-005453-4057qib7 5400 12 those those DT cord-005453-4057qib7 5400 13 identified identify VBN cord-005453-4057qib7 5400 14 at at IN cord-005453-4057qib7 5400 15 the the DT cord-005453-4057qib7 5400 16 ultimate ultimate JJ cord-005453-4057qib7 5400 17 time time NN cord-005453-4057qib7 5400 18 - - HYPH cord-005453-4057qib7 5400 19 point point NN cord-005453-4057qib7 5400 20 of of IN cord-005453-4057qib7 5400 21 GVHD GVHD NNP cord-005453-4057qib7 5400 22 occurrence occurrence NN cord-005453-4057qib7 5400 23 , , , cord-005453-4057qib7 5400 24 we -PRON- PRP cord-005453-4057qib7 5400 25 created create VBD cord-005453-4057qib7 5400 26 2 2 CD cord-005453-4057qib7 5400 27 sets set NNS cord-005453-4057qib7 5400 28 of of IN cord-005453-4057qib7 5400 29 5 5 CD cord-005453-4057qib7 5400 30 and and CC cord-005453-4057qib7 5400 31 7 7 CD cord-005453-4057qib7 5400 32 variants variant NNS cord-005453-4057qib7 5400 33 respectively respectively RB cord-005453-4057qib7 5400 34 for for IN cord-005453-4057qib7 5400 35 each each DT cord-005453-4057qib7 5400 36 patient patient NN cord-005453-4057qib7 5400 37 ( ( -LRB- cord-005453-4057qib7 5400 38 keeping keep VBG cord-005453-4057qib7 5400 39 only only RB cord-005453-4057qib7 5400 40 variants variant NNS cord-005453-4057qib7 5400 41 with with IN cord-005453-4057qib7 5400 42 at at RB cord-005453-4057qib7 5400 43 least least JJS cord-005453-4057qib7 5400 44 4 4 CD cord-005453-4057qib7 5400 45 reads read NNS cord-005453-4057qib7 5400 46 of of IN cord-005453-4057qib7 5400 47 mutated mutate VBN cord-005453-4057qib7 5400 48 DNA dna NN cord-005453-4057qib7 5400 49 ) ) -RRB- cord-005453-4057qib7 5400 50 . . . cord-005453-4057qib7 5401 1 These these DT cord-005453-4057qib7 5401 2 variants variant NNS cord-005453-4057qib7 5401 3 can can MD cord-005453-4057qib7 5401 4 be be VB cord-005453-4057qib7 5401 5 classified classify VBN cord-005453-4057qib7 5401 6 in in IN cord-005453-4057qib7 5401 7 2 2 CD cord-005453-4057qib7 5401 8 categories category NNS cord-005453-4057qib7 5401 9 : : : cord-005453-4057qib7 5402 1 ( ( -LRB- cord-005453-4057qib7 5402 2 i i NN cord-005453-4057qib7 5402 3 ) ) -RRB- cord-005453-4057qib7 5402 4 those those DT cord-005453-4057qib7 5402 5 with with IN cord-005453-4057qib7 5402 6 only only RB cord-005453-4057qib7 5402 7 with with IN cord-005453-4057qib7 5402 8 a a DT cord-005453-4057qib7 5402 9 slight slight JJ cord-005453-4057qib7 5402 10 increase increase NN cord-005453-4057qib7 5402 11 at at IN cord-005453-4057qib7 5402 12 time time NN cord-005453-4057qib7 5402 13 of of IN cord-005453-4057qib7 5402 14 GVHD GVHD NNP cord-005453-4057qib7 5402 15 , , , cord-005453-4057qib7 5402 16 i.e. i.e. FW cord-005453-4057qib7 5402 17 ≤ ≤ NN cord-005453-4057qib7 5402 18 2-fold 2-fold CD cord-005453-4057qib7 5402 19 compared compare VBN cord-005453-4057qib7 5402 20 to to IN cord-005453-4057qib7 5402 21 highest high JJS cord-005453-4057qib7 5402 22 previous previous JJ cord-005453-4057qib7 5402 23 VAF VAF NNP cord-005453-4057qib7 5402 24 ( ( -LRB- cord-005453-4057qib7 5402 25 LRRC43 lrrc43 UH cord-005453-4057qib7 5402 26 , , , cord-005453-4057qib7 5402 27 OR8U1 or8u1 RB cord-005453-4057qib7 5402 28 , , , cord-005453-4057qib7 5402 29 OR10G9 OR10G9 NNP cord-005453-4057qib7 5402 30 , , , cord-005453-4057qib7 5402 31 ALPP ALPP NNP cord-005453-4057qib7 5402 32 , , , cord-005453-4057qib7 5402 33 FRG1 FRG1 NNP cord-005453-4057qib7 5402 34 , , , cord-005453-4057qib7 5402 35 FRG2B FRG2B NNP cord-005453-4057qib7 5402 36 and and CC cord-005453-4057qib7 5402 37 LILRB3 LILRB3 NNP cord-005453-4057qib7 5402 38 genes gene NNS cord-005453-4057qib7 5402 39 ) ) -RRB- cord-005453-4057qib7 5402 40 , , , cord-005453-4057qib7 5402 41 and and CC cord-005453-4057qib7 5402 42 ( ( -LRB- cord-005453-4057qib7 5402 43 ii ii NN cord-005453-4057qib7 5402 44 ) ) -RRB- cord-005453-4057qib7 5402 45 those those DT cord-005453-4057qib7 5402 46 with with IN cord-005453-4057qib7 5402 47 a a DT cord-005453-4057qib7 5402 48 significant significant JJ cord-005453-4057qib7 5402 49 increase increase NN cord-005453-4057qib7 5402 50 at at IN cord-005453-4057qib7 5402 51 that that DT cord-005453-4057qib7 5402 52 time time NN cord-005453-4057qib7 5402 53 , , , cord-005453-4057qib7 5402 54 i.e. i.e. FW cord-005453-4057qib7 5402 55 > > XX cord-005453-4057qib7 5402 56 2-fold 2-fold CD cord-005453-4057qib7 5402 57 compared compare VBN cord-005453-4057qib7 5402 58 to to IN cord-005453-4057qib7 5402 59 highest high JJS cord-005453-4057qib7 5402 60 previous previous JJ cord-005453-4057qib7 5402 61 VAF VAF NNP cord-005453-4057qib7 5402 62 ( ( -LRB- cord-005453-4057qib7 5402 63 PHF2 PHF2 NNP cord-005453-4057qib7 5402 64 , , , cord-005453-4057qib7 5402 65 SMPD1 SMPD1 NNP cord-005453-4057qib7 5402 66 , , , cord-005453-4057qib7 5402 67 ERCC8 ERCC8 NNP cord-005453-4057qib7 5402 68 and and CC cord-005453-4057qib7 5402 69 KRTAP9 KRTAP9 NNS cord-005453-4057qib7 5402 70 - - HYPH cord-005453-4057qib7 5402 71 1 1 CD cord-005453-4057qib7 5402 72 genes gene NNS cord-005453-4057qib7 5402 73 ) ) -RRB- cord-005453-4057qib7 5402 74 . . . cord-005453-4057qib7 5403 1 None none NN cord-005453-4057qib7 5403 2 of of IN cord-005453-4057qib7 5403 3 the the DT cord-005453-4057qib7 5403 4 variants variant NNS cord-005453-4057qib7 5403 5 or or CC cord-005453-4057qib7 5403 6 genes gene NNS cord-005453-4057qib7 5403 7 involved involve VBN cord-005453-4057qib7 5403 8 was be VBD cord-005453-4057qib7 5403 9 common common JJ cord-005453-4057qib7 5403 10 between between IN cord-005453-4057qib7 5403 11 the the DT cord-005453-4057qib7 5403 12 2 2 CD cord-005453-4057qib7 5403 13 patients patient NNS cord-005453-4057qib7 5403 14 . . . cord-005453-4057qib7 5404 1 Ontology ontology NN cord-005453-4057qib7 5404 2 classification classification NN cord-005453-4057qib7 5404 3 of of IN cord-005453-4057qib7 5404 4 mutated mutate VBN cord-005453-4057qib7 5404 5 genes gene NNS cord-005453-4057qib7 5404 6 showed show VBD cord-005453-4057qib7 5404 7 the the DT cord-005453-4057qib7 5404 8 implication implication NN cord-005453-4057qib7 5404 9 of of IN cord-005453-4057qib7 5404 10 some some DT cord-005453-4057qib7 5404 11 of of IN cord-005453-4057qib7 5404 12 them -PRON- PRP cord-005453-4057qib7 5404 13 in in IN cord-005453-4057qib7 5404 14 cell cell NN cord-005453-4057qib7 5404 15 death death NN cord-005453-4057qib7 5404 16 , , , cord-005453-4057qib7 5404 17 regulation regulation NN cord-005453-4057qib7 5404 18 of of IN cord-005453-4057qib7 5404 19 MAP map NN cord-005453-4057qib7 5404 20 kinase kinase NN cord-005453-4057qib7 5404 21 activity activity NN cord-005453-4057qib7 5404 22 , , , cord-005453-4057qib7 5404 23 mRNA mrna NN cord-005453-4057qib7 5404 24 splicing splicing NN cord-005453-4057qib7 5404 25 and and CC cord-005453-4057qib7 5404 26 immune immune JJ cord-005453-4057qib7 5404 27 system system NN cord-005453-4057qib7 5404 28 process process NN cord-005453-4057qib7 5404 29 , , , cord-005453-4057qib7 5404 30 making make VBG cord-005453-4057qib7 5404 31 them -PRON- PRP cord-005453-4057qib7 5404 32 good good JJ cord-005453-4057qib7 5404 33 candidates candidate NNS cord-005453-4057qib7 5404 34 for for IN cord-005453-4057qib7 5404 35 further further JJ cord-005453-4057qib7 5404 36 studies study NNS cord-005453-4057qib7 5404 37 . . . cord-005453-4057qib7 5405 1 Identification identification NN cord-005453-4057qib7 5405 2 of of IN cord-005453-4057qib7 5405 3 variants variant NNS cord-005453-4057qib7 5405 4 appearing appear VBG cord-005453-4057qib7 5405 5 pre pre JJ cord-005453-4057qib7 5405 6 - - JJ cord-005453-4057qib7 5405 7 GVH gvh JJ cord-005453-4057qib7 5405 8 and and CC cord-005453-4057qib7 5405 9 turning turn VBG cord-005453-4057qib7 5405 10 off off RP cord-005453-4057qib7 5405 11 at at IN cord-005453-4057qib7 5405 12 time time NN cord-005453-4057qib7 5405 13 of of IN cord-005453-4057qib7 5405 14 GVHD GVHD NNP cord-005453-4057qib7 5406 1 is be VBZ cord-005453-4057qib7 5406 2 ongoing ongoing JJ cord-005453-4057qib7 5406 3 to to TO cord-005453-4057qib7 5406 4 unveil unveil VB cord-005453-4057qib7 5406 5 putative putative JJ cord-005453-4057qib7 5406 6 neoantigens neoantigen NNS cord-005453-4057qib7 5406 7 that that WDT cord-005453-4057qib7 5406 8 could could MD cord-005453-4057qib7 5406 9 trigger trigger VB cord-005453-4057qib7 5406 10 the the DT cord-005453-4057qib7 5406 11 alloreactive alloreactive JJ cord-005453-4057qib7 5406 12 response response NN cord-005453-4057qib7 5406 13 . . . cord-005453-4057qib7 5407 1 Conclusions conclusion NNS cord-005453-4057qib7 5407 2 : : : cord-005453-4057qib7 5408 1 Using use VBG cord-005453-4057qib7 5408 2 a a DT cord-005453-4057qib7 5408 3 comprehensive comprehensive JJ cord-005453-4057qib7 5408 4 , , , cord-005453-4057qib7 5408 5 pre pre JJ cord-005453-4057qib7 5408 6 - - JJ cord-005453-4057qib7 5408 7 and and CC cord-005453-4057qib7 5408 8 post post JJ cord-005453-4057qib7 5408 9 - - JJ cord-005453-4057qib7 5408 10 SCT SCT NNP cord-005453-4057qib7 5408 11 , , , cord-005453-4057qib7 5408 12 WES WES NNP cord-005453-4057qib7 5408 13 of of IN cord-005453-4057qib7 5408 14 donor donor NN cord-005453-4057qib7 5408 15 / / SYM cord-005453-4057qib7 5408 16 recipient recipient NN cord-005453-4057qib7 5408 17 pairs pair NNS cord-005453-4057qib7 5408 18 , , , cord-005453-4057qib7 5408 19 we -PRON- PRP cord-005453-4057qib7 5408 20 identified identify VBD cord-005453-4057qib7 5408 21 several several JJ cord-005453-4057qib7 5408 22 neomutations neomutation NNS cord-005453-4057qib7 5408 23 from from IN cord-005453-4057qib7 5408 24 donor donor NN cord-005453-4057qib7 5408 25 and/or and/or CC cord-005453-4057qib7 5408 26 recipient recipient NN cord-005453-4057qib7 5408 27 DNA dna NN cord-005453-4057qib7 5408 28 correlating correlate VBG cord-005453-4057qib7 5408 29 with with IN cord-005453-4057qib7 5408 30 GVH GVH NNP cord-005453-4057qib7 5408 31 / / SYM cord-005453-4057qib7 5408 32 GVT GVT NNP cord-005453-4057qib7 5408 33 effect effect NN cord-005453-4057qib7 5408 34 development development NN cord-005453-4057qib7 5408 35 . . . cord-005453-4057qib7 5409 1 Disclosure disclosure NN cord-005453-4057qib7 5409 2 Results result NNS cord-005453-4057qib7 5409 3 : : : cord-005453-4057qib7 5410 1 A a DT cord-005453-4057qib7 5410 2 total total NN cord-005453-4057qib7 5410 3 of of IN cord-005453-4057qib7 5410 4 169 169 CD cord-005453-4057qib7 5410 5 patients patient NNS cord-005453-4057qib7 5410 6 experienced experience VBD cord-005453-4057qib7 5410 7 cGVHD cGVHD NNP cord-005453-4057qib7 5410 8 , , , cord-005453-4057qib7 5410 9 and and CC cord-005453-4057qib7 5410 10 mild mild JJ cord-005453-4057qib7 5410 11 , , , cord-005453-4057qib7 5410 12 moderate moderate JJ cord-005453-4057qib7 5410 13 , , , cord-005453-4057qib7 5410 14 and and CC cord-005453-4057qib7 5410 15 severe severe JJ cord-005453-4057qib7 5410 16 cGVHD cGVHD NNP cord-005453-4057qib7 5410 17 were be VBD cord-005453-4057qib7 5410 18 observed observe VBN cord-005453-4057qib7 5410 19 in in IN cord-005453-4057qib7 5410 20 66 66 CD cord-005453-4057qib7 5410 21 , , , cord-005453-4057qib7 5410 22 67 67 CD cord-005453-4057qib7 5410 23 , , , cord-005453-4057qib7 5410 24 and and CC cord-005453-4057qib7 5410 25 36 36 CD cord-005453-4057qib7 5410 26 patients patient NNS cord-005453-4057qib7 5410 27 , , , cord-005453-4057qib7 5410 28 respectively respectively RB cord-005453-4057qib7 5410 29 . . . cord-005453-4057qib7 5411 1 The the DT cord-005453-4057qib7 5411 2 2-year 2-year CD cord-005453-4057qib7 5411 3 cumulative cumulative JJ cord-005453-4057qib7 5411 4 incidence incidence NN cord-005453-4057qib7 5411 5 of of IN cord-005453-4057qib7 5411 6 total total JJ cord-005453-4057qib7 5411 7 cGVHD cgvhd NN cord-005453-4057qib7 5411 8 was be VBD cord-005453-4057qib7 5411 9 60.5 60.5 CD cord-005453-4057qib7 5411 10 % % NN cord-005453-4057qib7 5411 11 ( ( -LRB- cord-005453-4057qib7 5411 12 95 95 CD cord-005453-4057qib7 5411 13 % % NN cord-005453-4057qib7 5411 14 CI CI NNP cord-005453-4057qib7 5411 15 , , , cord-005453-4057qib7 5411 16 54.7 54.7 CD cord-005453-4057qib7 5411 17 - - HYPH cord-005453-4057qib7 5411 18 66.3 66.3 CD cord-005453-4057qib7 5411 19 % % NN cord-005453-4057qib7 5411 20 ) ) -RRB- cord-005453-4057qib7 5411 21 , , , cord-005453-4057qib7 5411 22 and and CC cord-005453-4057qib7 5411 23 the the DT cord-005453-4057qib7 5411 24 2-year 2-year CD cord-005453-4057qib7 5411 25 cumulative cumulative JJ cord-005453-4057qib7 5411 26 incidence incidence NN cord-005453-4057qib7 5411 27 of of IN cord-005453-4057qib7 5411 28 moderate moderate JJ cord-005453-4057qib7 5411 29 to to TO cord-005453-4057qib7 5411 30 severe severe JJ cord-005453-4057qib7 5411 31 and and CC cord-005453-4057qib7 5411 32 severe severe JJ cord-005453-4057qib7 5411 33 cGVHD cgvhd NN cord-005453-4057qib7 5411 34 was be VBD cord-005453-4057qib7 5411 35 36.6 36.6 CD cord-005453-4057qib7 5411 36 % % NN cord-005453-4057qib7 5411 37 ( ( -LRB- cord-005453-4057qib7 5411 38 95 95 CD cord-005453-4057qib7 5411 39 % % NN cord-005453-4057qib7 5411 40 CI CI NNP cord-005453-4057qib7 5411 41 , , , cord-005453-4057qib7 5411 42 30.9 30.9 CD cord-005453-4057qib7 5411 43 - - SYM cord-005453-4057qib7 5411 44 42.3 42.3 CD cord-005453-4057qib7 5411 45 % % NN cord-005453-4057qib7 5411 46 ) ) -RRB- cord-005453-4057qib7 5411 47 and and CC cord-005453-4057qib7 5411 48 12.7 12.7 CD cord-005453-4057qib7 5411 49 % % NN cord-005453-4057qib7 5411 50 ( ( -LRB- cord-005453-4057qib7 5411 51 95 95 CD cord-005453-4057qib7 5411 52 % % NN cord-005453-4057qib7 5411 53 CI CI NNP cord-005453-4057qib7 5411 54 , , , cord-005453-4057qib7 5411 55 8.8 8.8 CD cord-005453-4057qib7 5411 56 - - SYM cord-005453-4057qib7 5411 57 16.6 16.6 CD cord-005453-4057qib7 5411 58 % % NN cord-005453-4057qib7 5411 59 ) ) -RRB- cord-005453-4057qib7 5411 60 , , , cord-005453-4057qib7 5411 61 respectively respectively RB cord-005453-4057qib7 5411 62 . . . cord-005453-4057qib7 5412 1 The the DT cord-005453-4057qib7 5412 2 patients patient NNS cord-005453-4057qib7 5412 3 who who WP cord-005453-4057qib7 5412 4 had have VBD cord-005453-4057qib7 5412 5 3 3 CD cord-005453-4057qib7 5412 6 loci locus NNS cord-005453-4057qib7 5412 7 mismatched mismatch VBN cord-005453-4057qib7 5412 8 had have VBD cord-005453-4057qib7 5412 9 a a DT cord-005453-4057qib7 5412 10 higher high JJR cord-005453-4057qib7 5412 11 2-year 2-year CD cord-005453-4057qib7 5412 12 cumulative cumulative JJ cord-005453-4057qib7 5412 13 incidence incidence NN cord-005453-4057qib7 5412 14 of of IN cord-005453-4057qib7 5412 15 total total JJ cord-005453-4057qib7 5412 16 cGVHD cgvhd NN cord-005453-4057qib7 5412 17 ( ( -LRB- cord-005453-4057qib7 5412 18 66.2 66.2 CD cord-005453-4057qib7 5412 19 % % NN cord-005453-4057qib7 5412 20 vs. vs. CC cord-005453-4057qib7 5412 21 54.5 54.5 CD cord-005453-4057qib7 5412 22 % % NN cord-005453-4057qib7 5412 23 , , , cord-005453-4057qib7 5412 24 P=0.025 P=0.025 NNP cord-005453-4057qib7 5412 25 ) ) -RRB- cord-005453-4057qib7 5412 26 and and CC cord-005453-4057qib7 5412 27 moderate moderate JJ cord-005453-4057qib7 5412 28 to to IN cord-005453-4057qib7 5412 29 severe severe JJ cord-005453-4057qib7 5412 30 cGVHD cgvhd NN cord-005453-4057qib7 5412 31 ( ( -LRB- cord-005453-4057qib7 5412 32 42.3 42.3 CD cord-005453-4057qib7 5412 33 % % NN cord-005453-4057qib7 5412 34 vs. vs. CC cord-005453-4057qib7 5412 35 30.6 30.6 CD cord-005453-4057qib7 5412 36 % % NN cord-005453-4057qib7 5412 37 , , , cord-005453-4057qib7 5412 38 P=0.028 p=0.028 NN cord-005453-4057qib7 5412 39 ) ) -RRB- cord-005453-4057qib7 5412 40 compared compare VBN cord-005453-4057qib7 5412 41 to to IN cord-005453-4057qib7 5412 42 those those DT cord-005453-4057qib7 5412 43 of of IN cord-005453-4057qib7 5412 44 the the DT cord-005453-4057qib7 5412 45 patients patient NNS cord-005453-4057qib7 5412 46 who who WP cord-005453-4057qib7 5412 47 had have VBD cord-005453-4057qib7 5412 48 1 1 CD cord-005453-4057qib7 5412 49 - - SYM cord-005453-4057qib7 5412 50 2 2 CD cord-005453-4057qib7 5412 51 loci locus NNS cord-005453-4057qib7 5412 52 mismatched mismatch VBN cord-005453-4057qib7 5412 53 . . . cord-005453-4057qib7 5413 1 The the DT cord-005453-4057qib7 5413 2 patients patient NNS cord-005453-4057qib7 5413 3 who who WP cord-005453-4057qib7 5413 4 had have VBD cord-005453-4057qib7 5413 5 maternal maternal JJ cord-005453-4057qib7 5413 6 donors donor NNS cord-005453-4057qib7 5413 7 had have VBD cord-005453-4057qib7 5413 8 a a DT cord-005453-4057qib7 5413 9 higher high JJR cord-005453-4057qib7 5413 10 2-year 2-year CD cord-005453-4057qib7 5413 11 cumulative cumulative JJ cord-005453-4057qib7 5413 12 incidence incidence NN cord-005453-4057qib7 5413 13 of of IN cord-005453-4057qib7 5413 14 moderate moderate JJ cord-005453-4057qib7 5413 15 to to IN cord-005453-4057qib7 5413 16 severe severe JJ cord-005453-4057qib7 5413 17 cGVHD cgvhd NN cord-005453-4057qib7 5413 18 ( ( -LRB- cord-005453-4057qib7 5413 19 50.8 50.8 CD cord-005453-4057qib7 5413 20 % % NN cord-005453-4057qib7 5413 21 vs. vs. CC cord-005453-4057qib7 5413 22 32.7 32.7 CD cord-005453-4057qib7 5413 23 % % NN cord-005453-4057qib7 5413 24 , , , cord-005453-4057qib7 5413 25 P=0.018 P=0.018 NNP cord-005453-4057qib7 5413 26 ) ) -RRB- cord-005453-4057qib7 5413 27 compared compare VBD cord-005453-4057qib7 5413 28 to to IN cord-005453-4057qib7 5413 29 that that DT cord-005453-4057qib7 5413 30 of of IN cord-005453-4057qib7 5413 31 the the DT cord-005453-4057qib7 5413 32 patients patient NNS cord-005453-4057qib7 5413 33 who who WP cord-005453-4057qib7 5413 34 had have VBD cord-005453-4057qib7 5413 35 other other JJ cord-005453-4057qib7 5413 36 donors donor NNS cord-005453-4057qib7 5413 37 . . . cord-005453-4057qib7 5414 1 The the DT cord-005453-4057qib7 5414 2 patients patient NNS cord-005453-4057qib7 5414 3 who who WP cord-005453-4057qib7 5414 4 had have VBD cord-005453-4057qib7 5414 5 grade grade NN cord-005453-4057qib7 5414 6 III III NNP cord-005453-4057qib7 5414 7 to to IN cord-005453-4057qib7 5414 8 IV IV NNP cord-005453-4057qib7 5414 9 acute acute JJ cord-005453-4057qib7 5414 10 graft graft NN cord-005453-4057qib7 5414 11 - - HYPH cord-005453-4057qib7 5414 12 versus versus IN cord-005453-4057qib7 5414 13 - - HYPH cord-005453-4057qib7 5414 14 host host NN cord-005453-4057qib7 5414 15 ( ( -LRB- cord-005453-4057qib7 5414 16 aGVHD aGVHD NNP cord-005453-4057qib7 5414 17 ) ) -RRB- cord-005453-4057qib7 5414 18 had have VBD cord-005453-4057qib7 5414 19 a a DT cord-005453-4057qib7 5414 20 higher high JJR cord-005453-4057qib7 5414 21 2-year 2-year CD cord-005453-4057qib7 5414 22 cumulative cumulative JJ cord-005453-4057qib7 5414 23 incidence incidence NN cord-005453-4057qib7 5414 24 of of IN cord-005453-4057qib7 5414 25 total total JJ cord-005453-4057qib7 5414 26 cGVHD cgvhd NN cord-005453-4057qib7 5414 27 ( ( -LRB- cord-005453-4057qib7 5414 28 91.7 91.7 CD cord-005453-4057qib7 5414 29 % % NN cord-005453-4057qib7 5414 30 vs. vs. IN cord-005453-4057qib7 5414 31 50.0 50.0 CD cord-005453-4057qib7 5414 32 % % NN cord-005453-4057qib7 5414 33 , , , cord-005453-4057qib7 5414 34 P p NN cord-005453-4057qib7 5414 35 < < XX cord-005453-4057qib7 5414 36 0.001 0.001 CD cord-005453-4057qib7 5414 37 ) ) -RRB- cord-005453-4057qib7 5414 38 and and CC cord-005453-4057qib7 5414 39 moderate moderate JJ cord-005453-4057qib7 5414 40 to to IN cord-005453-4057qib7 5414 41 severe severe JJ cord-005453-4057qib7 5414 42 cGVHD cgvhd NN cord-005453-4057qib7 5414 43 ( ( -LRB- cord-005453-4057qib7 5414 44 70.8 70.8 CD cord-005453-4057qib7 5414 45 % % NN cord-005453-4057qib7 5414 46 vs. vs. IN cord-005453-4057qib7 5414 47 26 26 CD cord-005453-4057qib7 5414 48 .3 .3 CD cord-005453-4057qib7 5414 49 % % NN cord-005453-4057qib7 5414 50 , , , cord-005453-4057qib7 5414 51 P p NN cord-005453-4057qib7 5414 52 < < XX cord-005453-4057qib7 5414 53 0.001 0.001 CD cord-005453-4057qib7 5414 54 ) ) -RRB- cord-005453-4057qib7 5414 55 compared compare VBD cord-005453-4057qib7 5414 56 to to IN cord-005453-4057qib7 5414 57 those those DT cord-005453-4057qib7 5414 58 of of IN cord-005453-4057qib7 5414 59 the the DT cord-005453-4057qib7 5414 60 patients patient NNS cord-005453-4057qib7 5414 61 without without IN cord-005453-4057qib7 5414 62 aGVHD aGVHD NNP cord-005453-4057qib7 5414 63 . . . cord-005453-4057qib7 5415 1 In in IN cord-005453-4057qib7 5415 2 multivariate multivariate JJ cord-005453-4057qib7 5415 3 analysis analysis NN cord-005453-4057qib7 5415 4 , , , cord-005453-4057qib7 5415 5 grade grade NN cord-005453-4057qib7 5415 6 III III NNP cord-005453-4057qib7 5415 7 to to IN cord-005453-4057qib7 5415 8 IV IV NNP cord-005453-4057qib7 5415 9 aGVHD aGVHD NNP cord-005453-4057qib7 5415 10 was be VBD cord-005453-4057qib7 5415 11 the the DT cord-005453-4057qib7 5415 12 only only JJ cord-005453-4057qib7 5415 13 independent independent JJ cord-005453-4057qib7 5415 14 risk risk NN cord-005453-4057qib7 5415 15 factor factor NN cord-005453-4057qib7 5415 16 for for IN cord-005453-4057qib7 5415 17 total total JJ cord-005453-4057qib7 5415 18 cGVHD cgvhd NN cord-005453-4057qib7 5416 1 ( ( -LRB- cord-005453-4057qib7 5416 2 HR=2.6 hr=2.6 NN cord-005453-4057qib7 5416 3 , , , cord-005453-4057qib7 5416 4 95%CI 95%ci CD cord-005453-4057qib7 5416 5 , , , cord-005453-4057qib7 5416 6 1.6 1.6 CD cord-005453-4057qib7 5416 7 - - SYM cord-005453-4057qib7 5416 8 4.2 4.2 CD cord-005453-4057qib7 5416 9 ; ; : cord-005453-4057qib7 5416 10 P p NN cord-005453-4057qib7 5416 11 < < XX cord-005453-4057qib7 5416 12 0.001 0.001 CD cord-005453-4057qib7 5416 13 ) ) -RRB- cord-005453-4057qib7 5416 14 and and CC cord-005453-4057qib7 5416 15 moderate moderate JJ cord-005453-4057qib7 5416 16 to to TO cord-005453-4057qib7 5416 17 severe severe JJ cord-005453-4057qib7 5416 18 cGVHD cgvhd NN cord-005453-4057qib7 5417 1 ( ( -LRB- cord-005453-4057qib7 5417 2 HR=3.8 HR=3.8 NNP cord-005453-4057qib7 5417 3 , , , cord-005453-4057qib7 5417 4 95%CI 95%ci CD cord-005453-4057qib7 5417 5 , , , cord-005453-4057qib7 5417 6 2.1 2.1 CD cord-005453-4057qib7 5417 7 - - SYM cord-005453-4057qib7 5417 8 6.7 6.7 CD cord-005453-4057qib7 5417 9 ; ; : cord-005453-4057qib7 5417 10 P p NN cord-005453-4057qib7 5417 11 < < XX cord-005453-4057qib7 5417 12 0.001 0.001 CD cord-005453-4057qib7 5417 13 ) ) -RRB- cord-005453-4057qib7 5417 14 . . . cord-005453-4057qib7 5418 1 In in IN cord-005453-4057qib7 5418 2 the the DT cord-005453-4057qib7 5418 3 model model NN cord-005453-4057qib7 5418 4 excluding exclude VBG cord-005453-4057qib7 5418 5 aGVHD aGVHD NNP cord-005453-4057qib7 5418 6 , , , cord-005453-4057qib7 5418 7 maternal maternal JJ cord-005453-4057qib7 5418 8 donor donor NN cord-005453-4057qib7 5418 9 was be VBD cord-005453-4057qib7 5418 10 the the DT cord-005453-4057qib7 5418 11 risk risk NN cord-005453-4057qib7 5418 12 factor factor NN cord-005453-4057qib7 5418 13 for for IN cord-005453-4057qib7 5418 14 moderate moderate JJ cord-005453-4057qib7 5418 15 to to TO cord-005453-4057qib7 5418 16 severe severe JJ cord-005453-4057qib7 5418 17 cGVHD cgvhd NN cord-005453-4057qib7 5419 1 ( ( -LRB- cord-005453-4057qib7 5419 2 HR=1.5 hr=1.5 NN cord-005453-4057qib7 5419 3 , , , cord-005453-4057qib7 5419 4 95%CI 95%ci CD cord-005453-4057qib7 5419 5 , , , cord-005453-4057qib7 5419 6 1.1 1.1 CD cord-005453-4057qib7 5419 7 - - SYM cord-005453-4057qib7 5419 8 2.3 2.3 CD cord-005453-4057qib7 5419 9 ; ; : cord-005453-4057qib7 5419 10 P=0.030 p=0.030 NN cord-005453-4057qib7 5419 11 ) ) -RRB- cord-005453-4057qib7 5419 12 . . . cord-005453-4057qib7 5420 1 Conclusions conclusion NNS cord-005453-4057qib7 5420 2 : : : cord-005453-4057qib7 5421 1 We -PRON- PRP cord-005453-4057qib7 5421 2 observe observe VBP cord-005453-4057qib7 5421 3 that that DT cord-005453-4057qib7 5421 4 severe severe JJ cord-005453-4057qib7 5421 5 aGVHD aGVHD NNP cord-005453-4057qib7 5421 6 was be VBD cord-005453-4057qib7 5421 7 the the DT cord-005453-4057qib7 5421 8 most most RBS cord-005453-4057qib7 5421 9 important important JJ cord-005453-4057qib7 5421 10 risk risk NN cord-005453-4057qib7 5421 11 factors factor NNS cord-005453-4057qib7 5421 12 for for IN cord-005453-4057qib7 5421 13 cGVHD cGVHD NNP cord-005453-4057qib7 5421 14 after after IN cord-005453-4057qib7 5421 15 haplo haplo NN cord-005453-4057qib7 5421 16 - - HYPH cord-005453-4057qib7 5421 17 HSCT HSCT NNP cord-005453-4057qib7 5421 18 , , , cord-005453-4057qib7 5421 19 and and CC cord-005453-4057qib7 5421 20 further further JJ cord-005453-4057qib7 5421 21 interventions intervention NNS cord-005453-4057qib7 5421 22 should should MD cord-005453-4057qib7 5421 23 be be VB cord-005453-4057qib7 5421 24 considered consider VBN cord-005453-4057qib7 5421 25 in in IN cord-005453-4057qib7 5421 26 these these DT cord-005453-4057qib7 5421 27 patients patient NNS cord-005453-4057qib7 5421 28 to to TO cord-005453-4057qib7 5421 29 prevent prevent VB cord-005453-4057qib7 5421 30 severe severe JJ cord-005453-4057qib7 5421 31 cGVHD cgvhd NN cord-005453-4057qib7 5421 32 . . . cord-005453-4057qib7 5422 1 Disclosure disclosure NN cord-005453-4057qib7 5422 2 : : : cord-005453-4057qib7 5423 1 None none NN cord-005453-4057qib7 5423 2 of of IN cord-005453-4057qib7 5423 3 the the DT cord-005453-4057qib7 5423 4 authors author NNS cord-005453-4057qib7 5423 5 have have VBP cord-005453-4057qib7 5423 6 any any DT cord-005453-4057qib7 5423 7 potential potential JJ cord-005453-4057qib7 5423 8 financial financial JJ cord-005453-4057qib7 5423 9 conflict conflict NN cord-005453-4057qib7 5423 10 of of IN cord-005453-4057qib7 5423 11 interest interest NN cord-005453-4057qib7 5423 12 related relate VBN cord-005453-4057qib7 5423 13 to to IN cord-005453-4057qib7 5423 14 this this DT cord-005453-4057qib7 5423 15 manuscript manuscript NN cord-005453-4057qib7 5423 16 . . . cord-005453-4057qib7 5424 1 Background background NN cord-005453-4057qib7 5424 2 : : : cord-005453-4057qib7 5425 1 Extracorporeal extracorporeal JJ cord-005453-4057qib7 5425 2 photopheresis photopheresis NN cord-005453-4057qib7 5425 3 ( ( -LRB- cord-005453-4057qib7 5425 4 ECP ECP NNP cord-005453-4057qib7 5425 5 ) ) -RRB- cord-005453-4057qib7 5425 6 has have VBZ cord-005453-4057qib7 5425 7 been be VBN cord-005453-4057qib7 5425 8 successfully successfully RB cord-005453-4057qib7 5425 9 used use VBN cord-005453-4057qib7 5425 10 for for IN cord-005453-4057qib7 5425 11 the the DT cord-005453-4057qib7 5425 12 treatment treatment NN cord-005453-4057qib7 5425 13 of of IN cord-005453-4057qib7 5425 14 graft graft NN cord-005453-4057qib7 5425 15 - - HYPH cord-005453-4057qib7 5425 16 versus versus IN cord-005453-4057qib7 5425 17 - - HYPH cord-005453-4057qib7 5425 18 host host NN cord-005453-4057qib7 5425 19 disease disease NN cord-005453-4057qib7 5425 20 ( ( -LRB- cord-005453-4057qib7 5425 21 GvHD GvHD NNP cord-005453-4057qib7 5425 22 ) ) -RRB- cord-005453-4057qib7 5425 23 . . . cord-005453-4057qib7 5426 1 ECP ECP NNP cord-005453-4057qib7 5426 2 therapy therapy NN cord-005453-4057qib7 5426 3 might may MD cord-005453-4057qib7 5426 4 restore restore VB cord-005453-4057qib7 5426 5 the the DT cord-005453-4057qib7 5426 6 balance balance NN cord-005453-4057qib7 5426 7 between between IN cord-005453-4057qib7 5426 8 effector effector NN cord-005453-4057qib7 5426 9 and and CC cord-005453-4057qib7 5426 10 regulatory regulatory JJ cord-005453-4057qib7 5426 11 cells cell NNS cord-005453-4057qib7 5426 12 which which WDT cord-005453-4057qib7 5426 13 is be VBZ cord-005453-4057qib7 5426 14 severely severely RB cord-005453-4057qib7 5426 15 impaired impaired JJ cord-005453-4057qib7 5426 16 in in IN cord-005453-4057qib7 5426 17 GvHD GvHD NNP cord-005453-4057qib7 5426 18 . . . cord-005453-4057qib7 5427 1 NK NK NNP cord-005453-4057qib7 5427 2 cells cell NNS cord-005453-4057qib7 5427 3 are be VBP cord-005453-4057qib7 5427 4 the the DT cord-005453-4057qib7 5427 5 first first JJ cord-005453-4057qib7 5427 6 lymphocyte lymphocyte NN cord-005453-4057qib7 5427 7 subset subset VBN cord-005453-4057qib7 5427 8 to to TO cord-005453-4057qib7 5427 9 be be VB cord-005453-4057qib7 5427 10 reconstituted reconstitute VBN cord-005453-4057qib7 5427 11 after after IN cord-005453-4057qib7 5427 12 allogeneic allogeneic JJ cord-005453-4057qib7 5427 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 5427 14 stem stem NN cord-005453-4057qib7 5427 15 cell cell NN cord-005453-4057qib7 5427 16 transplantation transplantation NN cord-005453-4057qib7 5427 17 ( ( -LRB- cord-005453-4057qib7 5427 18 allo allo NN cord-005453-4057qib7 5427 19 - - HYPH cord-005453-4057qib7 5427 20 HSCT HSCT NNP cord-005453-4057qib7 5427 21 ) ) -RRB- cord-005453-4057qib7 5427 22 . . . cord-005453-4057qib7 5428 1 As as IN cord-005453-4057qib7 5428 2 an an DT cord-005453-4057qib7 5428 3 important important JJ cord-005453-4057qib7 5428 4 innate innate JJ cord-005453-4057qib7 5428 5 immune immune JJ cord-005453-4057qib7 5428 6 cell cell NN cord-005453-4057qib7 5428 7 population population NN cord-005453-4057qib7 5428 8 , , , cord-005453-4057qib7 5428 9 NK NK NNP cord-005453-4057qib7 5428 10 cells cell NNS cord-005453-4057qib7 5428 11 can can MD cord-005453-4057qib7 5428 12 temporally temporally RB cord-005453-4057qib7 5428 13 bridge bridge VB cord-005453-4057qib7 5428 14 the the DT cord-005453-4057qib7 5428 15 transient transient JJ cord-005453-4057qib7 5428 16 period period NN cord-005453-4057qib7 5428 17 of of IN cord-005453-4057qib7 5428 18 T t NN cord-005453-4057qib7 5428 19 - - HYPH cord-005453-4057qib7 5428 20 cell cell NN cord-005453-4057qib7 5428 21 deficiency deficiency NN cord-005453-4057qib7 5428 22 post post FW cord-005453-4057qib7 5428 23 allo allo FW cord-005453-4057qib7 5428 24 - - HYPH cord-005453-4057qib7 5428 25 HSCT HSCT NNP cord-005453-4057qib7 5428 26 , , , cord-005453-4057qib7 5428 27 by by IN cord-005453-4057qib7 5428 28 protection protection NN cord-005453-4057qib7 5428 29 from from IN cord-005453-4057qib7 5428 30 opportunistic opportunistic JJ cord-005453-4057qib7 5428 31 infections infection NNS cord-005453-4057qib7 5428 32 and and CC cord-005453-4057qib7 5428 33 prevention prevention NN cord-005453-4057qib7 5428 34 of of IN cord-005453-4057qib7 5428 35 leukemic leukemic JJ cord-005453-4057qib7 5428 36 relapse relapse NN cord-005453-4057qib7 5428 37 by by IN cord-005453-4057qib7 5428 38 graft graft NN cord-005453-4057qib7 5428 39 - - HYPH cord-005453-4057qib7 5428 40 versus versus IN cord-005453-4057qib7 5428 41 - - HYPH cord-005453-4057qib7 5428 42 leukemia leukemia NN cord-005453-4057qib7 5428 43 ( ( -LRB- cord-005453-4057qib7 5428 44 GvL gvl NN cord-005453-4057qib7 5428 45 ) ) -RRB- cord-005453-4057qib7 5428 46 effect effect NN cord-005453-4057qib7 5428 47 . . . cord-005453-4057qib7 5429 1 NK NK NNP cord-005453-4057qib7 5429 2 cells cell NNS cord-005453-4057qib7 5429 3 not not RB cord-005453-4057qib7 5429 4 only only RB cord-005453-4057qib7 5429 5 preserve preserve VBP cord-005453-4057qib7 5429 6 homeostasis homeostasis NN cord-005453-4057qib7 5429 7 through through IN cord-005453-4057qib7 5429 8 targeted target VBN cord-005453-4057qib7 5429 9 killing killing NN cord-005453-4057qib7 5429 10 of of IN cord-005453-4057qib7 5429 11 allo allo NN cord-005453-4057qib7 5429 12 - - HYPH cord-005453-4057qib7 5429 13 reactive reactive JJ cord-005453-4057qib7 5429 14 T t NN cord-005453-4057qib7 5429 15 cells cell NNS cord-005453-4057qib7 5429 16 and and CC cord-005453-4057qib7 5429 17 thereby thereby RB cord-005453-4057qib7 5429 18 control control VB cord-005453-4057qib7 5429 19 GvHD GvHD NNP cord-005453-4057qib7 5429 20 but but CC cord-005453-4057qib7 5429 21 also also RB cord-005453-4057qib7 5429 22 enhance enhance VB cord-005453-4057qib7 5429 23 inflammation inflammation NN cord-005453-4057qib7 5429 24 by by IN cord-005453-4057qib7 5429 25 secretion secretion NN cord-005453-4057qib7 5429 26 of of IN cord-005453-4057qib7 5429 27 TNF TNF NNP cord-005453-4057qib7 5429 28 - - HYPH cord-005453-4057qib7 5429 29 α α NNP cord-005453-4057qib7 5429 30 and and CC cord-005453-4057qib7 5429 31 IFN IFN NNP cord-005453-4057qib7 5429 32 - - HYPH cord-005453-4057qib7 5429 33 γ γ NNP cord-005453-4057qib7 5429 34 and and CC cord-005453-4057qib7 5429 35 thereby thereby RB cord-005453-4057qib7 5429 36 promote promote VB cord-005453-4057qib7 5429 37 GvHD GvHD NNP cord-005453-4057qib7 5429 38 . . . cord-005453-4057qib7 5430 1 Therefore therefore RB cord-005453-4057qib7 5430 2 , , , cord-005453-4057qib7 5430 3 we -PRON- PRP cord-005453-4057qib7 5430 4 investigated investigate VBD cord-005453-4057qib7 5430 5 here here RB cord-005453-4057qib7 5430 6 the the DT cord-005453-4057qib7 5430 7 role role NN cord-005453-4057qib7 5430 8 of of IN cord-005453-4057qib7 5430 9 NK NK NNP cord-005453-4057qib7 5430 10 cells cell NNS cord-005453-4057qib7 5430 11 in in IN cord-005453-4057qib7 5430 12 GvHD gvhd NN cord-005453-4057qib7 5430 13 patients patient NNS cord-005453-4057qib7 5430 14 under under IN cord-005453-4057qib7 5430 15 ECP ECP NNP cord-005453-4057qib7 5430 16 therapy therapy NN cord-005453-4057qib7 5430 17 . . . cord-005453-4057qib7 5431 1 Methods method NNS cord-005453-4057qib7 5431 2 : : : cord-005453-4057qib7 5432 1 Thirty thirty CD cord-005453-4057qib7 5432 2 four four CD cord-005453-4057qib7 5432 3 patients patient NNS cord-005453-4057qib7 5432 4 with with IN cord-005453-4057qib7 5432 5 steroid steroid NN cord-005453-4057qib7 5432 6 - - HYPH cord-005453-4057qib7 5432 7 refractory/ refractory/ CD cord-005453-4057qib7 5432 8 resistant resistant JJ cord-005453-4057qib7 5432 9 aGvHD agvhd NN cord-005453-4057qib7 5432 10 ≥ ≥ CD cord-005453-4057qib7 5432 11 II II NNP cord-005453-4057qib7 5432 12 ° ° NNS cord-005453-4057qib7 5432 13 and and CC cord-005453-4057qib7 5432 14 moderate moderate JJ cord-005453-4057qib7 5432 15 to to IN cord-005453-4057qib7 5432 16 severe severe JJ cord-005453-4057qib7 5432 17 cGvHD cgvhd NN cord-005453-4057qib7 5432 18 received receive VBD cord-005453-4057qib7 5432 19 ECP ECP NNP cord-005453-4057qib7 5432 20 therapy therapy NN cord-005453-4057qib7 5432 21 which which WDT cord-005453-4057qib7 5432 22 performed perform VBD cord-005453-4057qib7 5432 23 according accord VBG cord-005453-4057qib7 5432 24 to to IN cord-005453-4057qib7 5432 25 the the DT cord-005453-4057qib7 5432 26 guidelines guideline NNS cord-005453-4057qib7 5432 27 . . . cord-005453-4057qib7 5433 1 Glucksberg Glucksberg NNP cord-005453-4057qib7 5433 2 and and CC cord-005453-4057qib7 5433 3 NIH NIH NNP cord-005453-4057qib7 5433 4 criteria criterion NNS cord-005453-4057qib7 5433 5 were be VBD cord-005453-4057qib7 5433 6 used use VBN cord-005453-4057qib7 5433 7 for for IN cord-005453-4057qib7 5433 8 clinical clinical JJ cord-005453-4057qib7 5433 9 staging staging NN cord-005453-4057qib7 5433 10 of of IN cord-005453-4057qib7 5433 11 aGvHD agvhd NN cord-005453-4057qib7 5433 12 and and CC cord-005453-4057qib7 5433 13 cGvHD cgvhd NN cord-005453-4057qib7 5433 14 under under IN cord-005453-4057qib7 5433 15 ECP ECP NNP cord-005453-4057qib7 5433 16 therapy therapy NN cord-005453-4057qib7 5433 17 , , , cord-005453-4057qib7 5433 18 respectively respectively RB cord-005453-4057qib7 5433 19 . . . cord-005453-4057qib7 5434 1 The the DT cord-005453-4057qib7 5434 2 comprehensive comprehensive JJ cord-005453-4057qib7 5434 3 phenotypical phenotypical JJ cord-005453-4057qib7 5434 4 analysis analysis NN cord-005453-4057qib7 5434 5 of of IN cord-005453-4057qib7 5434 6 NK NK NNP cord-005453-4057qib7 5434 7 cells cell NNS cord-005453-4057qib7 5434 8 was be VBD cord-005453-4057qib7 5434 9 evaluated evaluate VBN cord-005453-4057qib7 5434 10 by by IN cord-005453-4057qib7 5434 11 multicolor multicolor JJ cord-005453-4057qib7 5434 12 flow flow NN cord-005453-4057qib7 5434 13 cytometry cytometry NN cord-005453-4057qib7 5434 14 . . . cord-005453-4057qib7 5435 1 NK NK NNP cord-005453-4057qib7 5435 2 activity activity NN cord-005453-4057qib7 5435 3 in in IN cord-005453-4057qib7 5435 4 terms term NNS cord-005453-4057qib7 5435 5 of of IN cord-005453-4057qib7 5435 6 killing killing NN cord-005453-4057qib7 5435 7 function function NN cord-005453-4057qib7 5435 8 , , , cord-005453-4057qib7 5435 9 cytokine cytokine NN cord-005453-4057qib7 5435 10 release release NN cord-005453-4057qib7 5435 11 capacity capacity NN cord-005453-4057qib7 5435 12 and and CC cord-005453-4057qib7 5435 13 proliferation proliferation NN cord-005453-4057qib7 5435 14 function function NN cord-005453-4057qib7 5435 15 was be VBD cord-005453-4057qib7 5435 16 monitored monitor VBN cord-005453-4057qib7 5435 17 by by IN cord-005453-4057qib7 5435 18 chromium-51 chromium-51 NNP cord-005453-4057qib7 5435 19 release release NN cord-005453-4057qib7 5435 20 assay assay NN cord-005453-4057qib7 5435 21 , , , cord-005453-4057qib7 5435 22 intracellular intracellular JJ cord-005453-4057qib7 5435 23 cytokine cytokine NN cord-005453-4057qib7 5435 24 staining staining NN cord-005453-4057qib7 5435 25 and and CC cord-005453-4057qib7 5435 26 CFSE CFSE NNP cord-005453-4057qib7 5435 27 staining staining NN cord-005453-4057qib7 5435 28 , , , cord-005453-4057qib7 5435 29 respectively respectively RB cord-005453-4057qib7 5435 30 . . . cord-005453-4057qib7 5436 1 Results result NNS cord-005453-4057qib7 5436 2 : : : cord-005453-4057qib7 5437 1 Five five CD cord-005453-4057qib7 5437 2 different different JJ cord-005453-4057qib7 5437 3 NK NK NNP cord-005453-4057qib7 5437 4 cell cell NN cord-005453-4057qib7 5437 5 subsets subset NNS cord-005453-4057qib7 5437 6 were be VBD cord-005453-4057qib7 5437 7 defined define VBN cord-005453-4057qib7 5437 8 based base VBN cord-005453-4057qib7 5437 9 on on IN cord-005453-4057qib7 5437 10 CD56 CD56 NNP cord-005453-4057qib7 5437 11 and and CC cord-005453-4057qib7 5437 12 CD16 CD16 NNP cord-005453-4057qib7 5437 13 expression expression NN cord-005453-4057qib7 5437 14 . . . cord-005453-4057qib7 5438 1 CD56 cd56 NN cord-005453-4057qib7 5438 2 bri bri NNP cord-005453-4057qib7 5438 3 NK NK NNP cord-005453-4057qib7 5438 4 cells cell NNS cord-005453-4057qib7 5438 5 displayed display VBD cord-005453-4057qib7 5438 6 an an DT cord-005453-4057qib7 5438 7 immature immature JJ cord-005453-4057qib7 5438 8 and and CC cord-005453-4057qib7 5438 9 activation activation NN cord-005453-4057qib7 5438 10 profile profile NN cord-005453-4057qib7 5438 11 with with IN cord-005453-4057qib7 5438 12 high high JJ cord-005453-4057qib7 5438 13 expression expression NN cord-005453-4057qib7 5438 14 of of IN cord-005453-4057qib7 5438 15 CD62L cd62l NN cord-005453-4057qib7 5438 16 and and CC cord-005453-4057qib7 5438 17 NKG2D. NKG2D. NNP cord-005453-4057qib7 5438 18 aGvHD aGvHD NNP cord-005453-4057qib7 5438 19 patients patient NNS cord-005453-4057qib7 5438 20 had have VBD cord-005453-4057qib7 5438 21 a a DT cord-005453-4057qib7 5438 22 higher high JJR cord-005453-4057qib7 5438 23 frequency frequency NN cord-005453-4057qib7 5438 24 of of IN cord-005453-4057qib7 5438 25 CD56 CD56 NNP cord-005453-4057qib7 5438 26 bri bri NNP cord-005453-4057qib7 5438 27 NK NK NNP cord-005453-4057qib7 5438 28 cells cell NNS cord-005453-4057qib7 5438 29 when when WRB cord-005453-4057qib7 5438 30 compared compare VBN cord-005453-4057qib7 5438 31 with with IN cord-005453-4057qib7 5438 32 HDs hd NNS cord-005453-4057qib7 5438 33 and and CC cord-005453-4057qib7 5438 34 cGvHD cgvhd NN cord-005453-4057qib7 5438 35 patients patient NNS cord-005453-4057qib7 5438 36 , , , cord-005453-4057qib7 5438 37 who who WP cord-005453-4057qib7 5438 38 were be VBD cord-005453-4057qib7 5438 39 characterized characterize VBN cord-005453-4057qib7 5438 40 by by IN cord-005453-4057qib7 5438 41 significant significant JJ cord-005453-4057qib7 5438 42 increase increase NN cord-005453-4057qib7 5438 43 of of IN cord-005453-4057qib7 5438 44 the the DT cord-005453-4057qib7 5438 45 CD56 CD56 NNP cord-005453-4057qib7 5438 46 dim dim NN cord-005453-4057qib7 5438 47 CD16 CD16 NNP cord-005453-4057qib7 5439 1 + + CC cord-005453-4057qib7 5440 1 and and CC cord-005453-4057qib7 5440 2 CD56 CD56 NNP cord-005453-4057qib7 5440 3 -CD16 -CD16 VBD cord-005453-4057qib7 5440 4 + + CC cord-005453-4057qib7 5441 1 NK NK NNP cord-005453-4057qib7 5441 2 cell cell NN cord-005453-4057qib7 5441 3 subsets subset NNS cord-005453-4057qib7 5441 4 with with IN cord-005453-4057qib7 5441 5 high high JJ cord-005453-4057qib7 5441 6 expression expression NN cord-005453-4057qib7 5441 7 of of IN cord-005453-4057qib7 5441 8 differentiation differentiation NN cord-005453-4057qib7 5441 9 markers marker NNS cord-005453-4057qib7 5441 10 CD11b CD11b NNS cord-005453-4057qib7 5441 11 and and CC cord-005453-4057qib7 5441 12 CD57 CD57 NNP cord-005453-4057qib7 5441 13 . . . cord-005453-4057qib7 5442 1 Of of IN cord-005453-4057qib7 5442 2 note note NN cord-005453-4057qib7 5442 3 , , , cord-005453-4057qib7 5442 4 CD56 CD56 NNP cord-005453-4057qib7 5442 5 bri bri NNP cord-005453-4057qib7 5442 6 CD16 CD16 NNP cord-005453-4057qib7 5442 7 -NK -NK HYPH cord-005453-4057qib7 5442 8 cells cell NNS cord-005453-4057qib7 5442 9 could could MD cord-005453-4057qib7 5442 10 serve serve VB cord-005453-4057qib7 5442 11 as as IN cord-005453-4057qib7 5442 12 a a DT cord-005453-4057qib7 5442 13 novel novel JJ cord-005453-4057qib7 5442 14 predictive predictive JJ cord-005453-4057qib7 5442 15 biomarker biomarker NN cord-005453-4057qib7 5442 16 for for IN cord-005453-4057qib7 5442 17 the the DT cord-005453-4057qib7 5442 18 response response NN cord-005453-4057qib7 5442 19 of of IN cord-005453-4057qib7 5442 20 aGvHD agvhd NN cord-005453-4057qib7 5442 21 patients patient NNS cord-005453-4057qib7 5442 22 to to IN cord-005453-4057qib7 5442 23 ECP ECP NNP cord-005453-4057qib7 5442 24 treatment treatment NN cord-005453-4057qib7 5442 25 . . . cord-005453-4057qib7 5443 1 In in IN cord-005453-4057qib7 5443 2 responding respond VBG cord-005453-4057qib7 5443 3 aGvHD agvhd NN cord-005453-4057qib7 5443 4 patients patient NNS cord-005453-4057qib7 5443 5 , , , cord-005453-4057qib7 5443 6 an an DT cord-005453-4057qib7 5443 7 increase increase NN cord-005453-4057qib7 5443 8 of of IN cord-005453-4057qib7 5443 9 CD56 CD56 NNP cord-005453-4057qib7 5443 10 bri bri NNP cord-005453-4057qib7 5443 11 NK NK NNP cord-005453-4057qib7 5443 12 cells cell NNS cord-005453-4057qib7 5443 13 was be VBD cord-005453-4057qib7 5443 14 observed observe VBN cord-005453-4057qib7 5443 15 already already RB cord-005453-4057qib7 5443 16 during during IN cord-005453-4057qib7 5443 17 the the DT cord-005453-4057qib7 5443 18 early early JJ cord-005453-4057qib7 5443 19 ECP ECP NNP cord-005453-4057qib7 5443 20 treatment treatment NN cord-005453-4057qib7 5443 21 phase phase NN cord-005453-4057qib7 5443 22 , , , cord-005453-4057qib7 5443 23 suggesting suggest VBG cord-005453-4057qib7 5443 24 immune immune JJ cord-005453-4057qib7 5443 25 reconstitution reconstitution NN cord-005453-4057qib7 5443 26 . . . cord-005453-4057qib7 5444 1 After after IN cord-005453-4057qib7 5444 2 priming prime VBG cord-005453-4057qib7 5444 3 of of IN cord-005453-4057qib7 5444 4 the the DT cord-005453-4057qib7 5444 5 progenitors progenitor NNS cord-005453-4057qib7 5444 6 , , , cord-005453-4057qib7 5444 7 ECP ECP NNP cord-005453-4057qib7 5444 8 could could MD cord-005453-4057qib7 5444 9 differentiate differentiate VB cord-005453-4057qib7 5444 10 immature immature JJ cord-005453-4057qib7 5444 11 CD56 CD56 NNP cord-005453-4057qib7 5444 12 bri bri NNP cord-005453-4057qib7 5444 13 NK NK NNP cord-005453-4057qib7 5444 14 cells cell NNS cord-005453-4057qib7 5444 15 into into IN cord-005453-4057qib7 5444 16 mature mature JJ cord-005453-4057qib7 5444 17 CD56 CD56 NNP cord-005453-4057qib7 5444 18 dim dim NN cord-005453-4057qib7 5444 19 NK NK NNP cord-005453-4057qib7 5444 20 cells cell NNS cord-005453-4057qib7 5444 21 with with IN cord-005453-4057qib7 5444 22 reduction reduction NN cord-005453-4057qib7 5444 23 of of IN cord-005453-4057qib7 5444 24 CD62L cd62l NN cord-005453-4057qib7 5444 25 on on IN cord-005453-4057qib7 5444 26 CD56 CD56 NNP cord-005453-4057qib7 5444 27 bri bri NNP cord-005453-4057qib7 5444 28 NK NK NNP cord-005453-4057qib7 5444 29 cells cell NNS cord-005453-4057qib7 5444 30 . . . cord-005453-4057qib7 5445 1 Moreover moreover RB cord-005453-4057qib7 5445 2 , , , cord-005453-4057qib7 5445 3 CD56 CD56 NNP cord-005453-4057qib7 5445 4 dim dim NN cord-005453-4057qib7 5445 5 NK NK NNP cord-005453-4057qib7 5445 6 cells cell NNS cord-005453-4057qib7 5445 7 could could MD cord-005453-4057qib7 5445 8 further further RB cord-005453-4057qib7 5445 9 be be VB cord-005453-4057qib7 5445 10 matured mature VBN cord-005453-4057qib7 5445 11 through through IN cord-005453-4057qib7 5445 12 upregulation upregulation NN cord-005453-4057qib7 5445 13 of of IN cord-005453-4057qib7 5445 14 CD57 cd57 JJ cord-005453-4057qib7 5445 15 expression expression NN cord-005453-4057qib7 5445 16 by by IN cord-005453-4057qib7 5445 17 ECP ECP NNP cord-005453-4057qib7 5445 18 . . . cord-005453-4057qib7 5446 1 Notably notably RB cord-005453-4057qib7 5446 2 , , , cord-005453-4057qib7 5446 3 ECP ECP NNP cord-005453-4057qib7 5446 4 therapy therapy NN cord-005453-4057qib7 5446 5 could could MD cord-005453-4057qib7 5446 6 shift shift VB cord-005453-4057qib7 5446 7 the the DT cord-005453-4057qib7 5446 8 NK NK NNP cord-005453-4057qib7 5446 9 cells cell NNS cord-005453-4057qib7 5446 10 from from IN cord-005453-4057qib7 5446 11 a a DT cord-005453-4057qib7 5446 12 cytotoxic cytotoxic NN cord-005453-4057qib7 5446 13 to to IN cord-005453-4057qib7 5446 14 a a DT cord-005453-4057qib7 5446 15 regulatory regulatory JJ cord-005453-4057qib7 5446 16 phenotype phenotype NN cord-005453-4057qib7 5446 17 within within IN cord-005453-4057qib7 5446 18 the the DT cord-005453-4057qib7 5446 19 CD56 CD56 NNP cord-005453-4057qib7 5446 20 bri bri NNP cord-005453-4057qib7 5446 21 NK NK NNP cord-005453-4057qib7 5446 22 cells cell NNS cord-005453-4057qib7 5446 23 . . . cord-005453-4057qib7 5447 1 In in IN cord-005453-4057qib7 5447 2 spite spite NN cord-005453-4057qib7 5447 3 the the DT cord-005453-4057qib7 5447 4 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 5447 5 effect effect NN cord-005453-4057qib7 5447 6 of of IN cord-005453-4057qib7 5447 7 ECP ECP NNP cord-005453-4057qib7 5447 8 on on IN cord-005453-4057qib7 5447 9 NK NK NNP cord-005453-4057qib7 5447 10 cells cell NNS cord-005453-4057qib7 5447 11 , , , cord-005453-4057qib7 5447 12 NK NK NNP cord-005453-4057qib7 5447 13 activity activity NN cord-005453-4057qib7 5447 14 could could MD cord-005453-4057qib7 5447 15 be be VB cord-005453-4057qib7 5447 16 kept keep VBN cord-005453-4057qib7 5447 17 intact intact JJ cord-005453-4057qib7 5447 18 under under IN cord-005453-4057qib7 5447 19 ECP ECP NNP cord-005453-4057qib7 5447 20 therapy therapy NN cord-005453-4057qib7 5447 21 . . . cord-005453-4057qib7 5448 1 The the DT cord-005453-4057qib7 5448 2 killing killing NN cord-005453-4057qib7 5448 3 activity activity NN cord-005453-4057qib7 5448 4 of of IN cord-005453-4057qib7 5448 5 NK NK NNP cord-005453-4057qib7 5448 6 cells cell NNS cord-005453-4057qib7 5448 7 was be VBD cord-005453-4057qib7 5448 8 stable stable JJ cord-005453-4057qib7 5448 9 as as IN cord-005453-4057qib7 5448 10 confirmed confirm VBN cord-005453-4057qib7 5448 11 by by IN cord-005453-4057qib7 5448 12 a a DT cord-005453-4057qib7 5448 13 51 51 CD cord-005453-4057qib7 5448 14 Cr cr NN cord-005453-4057qib7 5448 15 release release NN cord-005453-4057qib7 5448 16 assay assay NN cord-005453-4057qib7 5448 17 . . . cord-005453-4057qib7 5449 1 ECP ECP NNP cord-005453-4057qib7 5449 2 therapy therapy NN cord-005453-4057qib7 5449 3 had have VBD cord-005453-4057qib7 5449 4 no no DT cord-005453-4057qib7 5449 5 negative negative JJ cord-005453-4057qib7 5449 6 effect effect NN cord-005453-4057qib7 5449 7 on on IN cord-005453-4057qib7 5449 8 the the DT cord-005453-4057qib7 5449 9 quantity quantity NN cord-005453-4057qib7 5449 10 and and CC cord-005453-4057qib7 5449 11 quality quality NN cord-005453-4057qib7 5449 12 of of IN cord-005453-4057qib7 5449 13 cytokine cytokine NN cord-005453-4057qib7 5449 14 release release NN cord-005453-4057qib7 5449 15 by by IN cord-005453-4057qib7 5449 16 NK NK NNP cord-005453-4057qib7 5449 17 cells cell NNS cord-005453-4057qib7 5449 18 upon upon IN cord-005453-4057qib7 5449 19 K562 k562 CD cord-005453-4057qib7 5449 20 stimulation stimulation NN cord-005453-4057qib7 5449 21 . . . cord-005453-4057qib7 5450 1 Especially especially RB cord-005453-4057qib7 5450 2 , , , cord-005453-4057qib7 5450 3 the the DT cord-005453-4057qib7 5450 4 polyfunctionality polyfunctionality NN cord-005453-4057qib7 5450 5 of of IN cord-005453-4057qib7 5450 6 NK NK NNP cord-005453-4057qib7 5450 7 cells cell NNS cord-005453-4057qib7 5450 8 was be VBD cord-005453-4057qib7 5450 9 not not RB cord-005453-4057qib7 5450 10 altered alter VBN cord-005453-4057qib7 5450 11 significantly significantly RB cord-005453-4057qib7 5450 12 by by IN cord-005453-4057qib7 5450 13 the the DT cord-005453-4057qib7 5450 14 ECP ECP NNP cord-005453-4057qib7 5450 15 therapy therapy NN cord-005453-4057qib7 5450 16 . . . cord-005453-4057qib7 5451 1 Conclusions conclusion NNS cord-005453-4057qib7 5451 2 : : : cord-005453-4057qib7 5451 3 NK NK NNP cord-005453-4057qib7 5451 4 cells cell NNS cord-005453-4057qib7 5451 5 play play VBP cord-005453-4057qib7 5451 6 an an DT cord-005453-4057qib7 5451 7 important important JJ cord-005453-4057qib7 5451 8 role role NN cord-005453-4057qib7 5451 9 in in IN cord-005453-4057qib7 5451 10 GvHD GvHD NNP cord-005453-4057qib7 5451 11 and and CC cord-005453-4057qib7 5451 12 could could MD cord-005453-4057qib7 5451 13 serve serve VB cord-005453-4057qib7 5451 14 as as IN cord-005453-4057qib7 5451 15 a a DT cord-005453-4057qib7 5451 16 predictive predictive JJ cord-005453-4057qib7 5451 17 cell cell NN cord-005453-4057qib7 5451 18 population population NN cord-005453-4057qib7 5451 19 for for IN cord-005453-4057qib7 5451 20 the the DT cord-005453-4057qib7 5451 21 clinical clinical JJ cord-005453-4057qib7 5451 22 response response NN cord-005453-4057qib7 5451 23 to to IN cord-005453-4057qib7 5451 24 ECP ECP NNP cord-005453-4057qib7 5451 25 therapy therapy NN cord-005453-4057qib7 5451 26 . . . cord-005453-4057qib7 5452 1 In in IN cord-005453-4057qib7 5452 2 the the DT cord-005453-4057qib7 5452 3 current current JJ cord-005453-4057qib7 5452 4 study study NN cord-005453-4057qib7 5452 5 , , , cord-005453-4057qib7 5452 6 ECP ECP NNP cord-005453-4057qib7 5452 7 influenced influence VBD cord-005453-4057qib7 5452 8 the the DT cord-005453-4057qib7 5452 9 differentiation differentiation NN cord-005453-4057qib7 5452 10 , , , cord-005453-4057qib7 5452 11 maturation maturation NN cord-005453-4057qib7 5452 12 and and CC cord-005453-4057qib7 5452 13 education education NN cord-005453-4057qib7 5452 14 of of IN cord-005453-4057qib7 5452 15 NK NK NNP cord-005453-4057qib7 5452 16 cells cell NNS cord-005453-4057qib7 5452 17 ameliorating ameliorate VBG cord-005453-4057qib7 5452 18 GvHD GvHD NNP cord-005453-4057qib7 5452 19 without without IN cord-005453-4057qib7 5452 20 comprising comprise VBG cord-005453-4057qib7 5452 21 the the DT cord-005453-4057qib7 5452 22 antiviral antiviral JJ cord-005453-4057qib7 5452 23 immune immune JJ cord-005453-4057qib7 5452 24 defense defense NN cord-005453-4057qib7 5452 25 and and CC cord-005453-4057qib7 5452 26 GvL gvl NN cord-005453-4057qib7 5452 27 effect effect NN cord-005453-4057qib7 5452 28 . . . cord-005453-4057qib7 5453 1 Disclosure disclosure NN cord-005453-4057qib7 5453 2 : : : cord-005453-4057qib7 5454 1 The the DT cord-005453-4057qib7 5454 2 authors author NNS cord-005453-4057qib7 5454 3 declare declare VBP cord-005453-4057qib7 5454 4 no no DT cord-005453-4057qib7 5454 5 competing compete VBG cord-005453-4057qib7 5454 6 financial financial JJ cord-005453-4057qib7 5454 7 interests interest NNS cord-005453-4057qib7 5454 8 , , , cord-005453-4057qib7 5454 9 except except IN cord-005453-4057qib7 5454 10 the the DT cord-005453-4057qib7 5454 11 following following NN cord-005453-4057qib7 5454 12 : : : cord-005453-4057qib7 5454 13 Therakos Therakos NNP cord-005453-4057qib7 5454 14 Mallinckrodt Mallinckrodt NNP cord-005453-4057qib7 5454 15 gave give VBD cord-005453-4057qib7 5454 16 a a DT cord-005453-4057qib7 5454 17 financial financial JJ cord-005453-4057qib7 5454 18 support support NN cord-005453-4057qib7 5454 19 to to IN cord-005453-4057qib7 5454 20 AS AS NNP cord-005453-4057qib7 5454 21 and and CC cord-005453-4057qib7 5454 22 MS MS NNP cord-005453-4057qib7 5454 23 for for IN cord-005453-4057qib7 5454 24 the the DT cord-005453-4057qib7 5454 25 documentation documentation NN cord-005453-4057qib7 5454 26 of of IN cord-005453-4057qib7 5454 27 the the DT cord-005453-4057qib7 5454 28 clinical clinical JJ cord-005453-4057qib7 5454 29 course course NN cord-005453-4057qib7 5454 30 and and CC cord-005453-4057qib7 5454 31 for for IN cord-005453-4057qib7 5454 32 the the DT cord-005453-4057qib7 5454 33 analysis analysis NN cord-005453-4057qib7 5454 34 of of IN cord-005453-4057qib7 5454 35 immune immune JJ cord-005453-4057qib7 5454 36 cells cell NNS cord-005453-4057qib7 5454 37 of of IN cord-005453-4057qib7 5454 38 the the DT cord-005453-4057qib7 5454 39 patients patient NNS cord-005453-4057qib7 5454 40 , , , cord-005453-4057qib7 5454 41 PW PW NNP cord-005453-4057qib7 5454 42 has have VBZ cord-005453-4057qib7 5454 43 Honoraria Honoraria NNP cord-005453-4057qib7 5454 44 and and CC cord-005453-4057qib7 5454 45 membership membership NN cord-005453-4057qib7 5454 46 on on IN cord-005453-4057qib7 5454 47 Advisory Advisory NNP cord-005453-4057qib7 5454 48 Boards Boards NNP cord-005453-4057qib7 5454 49 for for IN cord-005453-4057qib7 5454 50 Sanofi Sanofi NNP cord-005453-4057qib7 5454 51 - - HYPH cord-005453-4057qib7 5454 52 Aventis Aventis NNP cord-005453-4057qib7 5454 53 . . . cord-005453-4057qib7 5455 1 Abstract Abstract NNP cord-005453-4057qib7 5455 2 withdrawn withdraw VBN cord-005453-4057qib7 5455 3 . . . cord-005453-4057qib7 5456 1 Cyclosporine cyclosporine JJ cord-005453-4057qib7 5456 2 levels level NNS cord-005453-4057qib7 5456 3 > > XX cord-005453-4057qib7 5457 1 200µG 200µG NNP cord-005453-4057qib7 5457 2 / / SYM cord-005453-4057qib7 5457 3 L L NNP cord-005453-4057qib7 5457 4 on on IN cord-005453-4057qib7 5457 5 day day NN cord-005453-4057qib7 5457 6 10 10 CD cord-005453-4057qib7 5457 7 post post JJ cord-005453-4057qib7 5457 8 - - JJ cord-005453-4057qib7 5457 9 transplant transplant NN cord-005453-4057qib7 5457 10 was be VBD cord-005453-4057qib7 5457 11 associated associate VBN cord-005453-4057qib7 5457 12 with with IN cord-005453-4057qib7 5457 13 significantly significantly RB cord-005453-4057qib7 5457 14 reduced reduce VBN cord-005453-4057qib7 5457 15 acute acute JJ cord-005453-4057qib7 5457 16 graftversus graftversus NN cord-005453-4057qib7 5457 17 - - HYPH cord-005453-4057qib7 5457 18 host host NN cord-005453-4057qib7 5457 19 disease disease NN cord-005453-4057qib7 5457 20 following follow VBG cord-005453-4057qib7 5457 21 allogeneic allogeneic IN cord-005453-4057qib7 5457 22 hematopoietic hematopoietic JJ cord-005453-4057qib7 5457 23 stem stem NN cord-005453-4057qib7 5457 24 cell cell NN cord-005453-4057qib7 5457 25 transplantation transplantation NN cord-005453-4057qib7 5457 26 Monica Monica NNP cord-005453-4057qib7 5457 27 Bianchi Bianchi NNP cord-005453-4057qib7 5457 28 1 1 CD cord-005453-4057qib7 5458 1 , , , cord-005453-4057qib7 5458 2 Dominik Dominik NNP cord-005453-4057qib7 5458 3 Heim Heim NNP cord-005453-4057qib7 5458 4 1 1 CD cord-005453-4057qib7 5458 5 , , , cord-005453-4057qib7 5458 6 Claudia Claudia NNP cord-005453-4057qib7 5458 7 Lengerke Lengerke NNP cord-005453-4057qib7 5458 8 1 1 CD cord-005453-4057qib7 5458 9 , , , cord-005453-4057qib7 5458 10 Martina Martina NNP cord-005453-4057qib7 5458 11 Kleber Kleber NNP cord-005453-4057qib7 5458 12 1 1 CD cord-005453-4057qib7 5458 13 , , , cord-005453-4057qib7 5458 14 Dimitrios Dimitrios NNP cord-005453-4057qib7 5458 15 Tsakiris Tsakiris NNP cord-005453-4057qib7 5458 16 1 1 CD cord-005453-4057qib7 5458 17 , , , cord-005453-4057qib7 5458 18 Jakob Jakob NNP cord-005453-4057qib7 5458 19 Passweg Passweg NNP cord-005453-4057qib7 5458 20 1 1 CD cord-005453-4057qib7 5458 21 , , , cord-005453-4057qib7 5458 22 Alexandar Alexandar NNP cord-005453-4057qib7 5458 23 Tzankov Tzankov NNP cord-005453-4057qib7 5458 24 2 2 CD cord-005453-4057qib7 5458 25 , , , cord-005453-4057qib7 5458 26 Michael Michael NNP cord-005453-4057qib7 5458 27 Medinger Medinger NNP cord-005453-4057qib7 5458 28 1 1 CD cord-005453-4057qib7 5458 29 Background Background NNP cord-005453-4057qib7 5458 30 : : : cord-005453-4057qib7 5459 1 Acute acute JJ cord-005453-4057qib7 5459 2 Graft graft NN cord-005453-4057qib7 5459 3 - - HYPH cord-005453-4057qib7 5459 4 versus versus IN cord-005453-4057qib7 5459 5 - - HYPH cord-005453-4057qib7 5459 6 host host NN cord-005453-4057qib7 5459 7 disease disease NN cord-005453-4057qib7 5459 8 ( ( -LRB- cord-005453-4057qib7 5459 9 aGvHD agvhd NN cord-005453-4057qib7 5459 10 ) ) -RRB- cord-005453-4057qib7 5459 11 remains remain VBZ cord-005453-4057qib7 5459 12 a a DT cord-005453-4057qib7 5459 13 major major JJ cord-005453-4057qib7 5459 14 complication complication NN cord-005453-4057qib7 5459 15 of of IN cord-005453-4057qib7 5459 16 allogeneic allogeneic JJ cord-005453-4057qib7 5459 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 5459 18 stem stem NN cord-005453-4057qib7 5459 19 cell cell NN cord-005453-4057qib7 5459 20 transplantation transplantation NN cord-005453-4057qib7 5459 21 ( ( -LRB- cord-005453-4057qib7 5459 22 allo allo NN cord-005453-4057qib7 5459 23 - - HYPH cord-005453-4057qib7 5459 24 HSCT HSCT NNP cord-005453-4057qib7 5459 25 ) ) -RRB- cord-005453-4057qib7 5459 26 . . . cord-005453-4057qib7 5460 1 Affected affected JJ cord-005453-4057qib7 5460 2 patients patient NNS cord-005453-4057qib7 5460 3 , , , cord-005453-4057qib7 5460 4 especially especially RB cord-005453-4057qib7 5460 5 with with IN cord-005453-4057qib7 5460 6 steroid steroid JJ cord-005453-4057qib7 5460 7 - - HYPH cord-005453-4057qib7 5460 8 refractory refractory JJ cord-005453-4057qib7 5460 9 aGvHD agvhd NN cord-005453-4057qib7 5460 10 , , , cord-005453-4057qib7 5460 11 have have VBP cord-005453-4057qib7 5460 12 a a DT cord-005453-4057qib7 5460 13 very very RB cord-005453-4057qib7 5460 14 poor poor JJ cord-005453-4057qib7 5460 15 prognosis prognosis NN cord-005453-4057qib7 5460 16 . . . cord-005453-4057qib7 5461 1 Prophylaxis prophylaxis NN cord-005453-4057qib7 5461 2 with with IN cord-005453-4057qib7 5461 3 cyclosporine cyclosporine NN cord-005453-4057qib7 5461 4 A a NN cord-005453-4057qib7 5461 5 ( ( -LRB- cord-005453-4057qib7 5461 6 CsA CsA NNP cord-005453-4057qib7 5461 7 ) ) -RRB- cord-005453-4057qib7 5461 8 is be VBZ cord-005453-4057qib7 5461 9 the the DT cord-005453-4057qib7 5461 10 backbone backbone NN cord-005453-4057qib7 5461 11 of of IN cord-005453-4057qib7 5461 12 GvHD GvHD NNP cord-005453-4057qib7 5461 13 prevention prevention NN cord-005453-4057qib7 5461 14 in in IN cord-005453-4057qib7 5461 15 most most JJS cord-005453-4057qib7 5461 16 conditioning conditioning NN cord-005453-4057qib7 5461 17 regimens regimen NNS cord-005453-4057qib7 5461 18 . . . cord-005453-4057qib7 5462 1 Methods method NNS cord-005453-4057qib7 5462 2 : : : cord-005453-4057qib7 5462 3 In in IN cord-005453-4057qib7 5462 4 a a DT cord-005453-4057qib7 5462 5 retrospective retrospective JJ cord-005453-4057qib7 5462 6 analysis analysis NN cord-005453-4057qib7 5462 7 of of IN cord-005453-4057qib7 5462 8 patients patient NNS cord-005453-4057qib7 5462 9 treated treat VBN cord-005453-4057qib7 5462 10 with with IN cord-005453-4057qib7 5462 11 allo allo NN cord-005453-4057qib7 5462 12 - - HYPH cord-005453-4057qib7 5462 13 HSCT HSCT NNP cord-005453-4057qib7 5462 14 , , , cord-005453-4057qib7 5462 15 we -PRON- PRP cord-005453-4057qib7 5462 16 correlated correlate VBD cord-005453-4057qib7 5462 17 CsA csa NN cord-005453-4057qib7 5462 18 levels level NNS cord-005453-4057qib7 5462 19 at at IN cord-005453-4057qib7 5462 20 the the DT cord-005453-4057qib7 5462 21 day day NN cord-005453-4057qib7 5462 22 of of IN cord-005453-4057qib7 5462 23 transplantation transplantation NN cord-005453-4057qib7 5462 24 ( ( -LRB- cord-005453-4057qib7 5462 25 day day NN cord-005453-4057qib7 5462 26 0 0 CD cord-005453-4057qib7 5462 27 ) ) -RRB- cord-005453-4057qib7 5462 28 and and CC cord-005453-4057qib7 5462 29 day day NN cord-005453-4057qib7 5462 30 +10 +10 CD cord-005453-4057qib7 5462 31 with with IN cord-005453-4057qib7 5462 32 the the DT cord-005453-4057qib7 5462 33 incidence incidence NN cord-005453-4057qib7 5462 34 of of IN cord-005453-4057qib7 5462 35 acute acute JJ cord-005453-4057qib7 5462 36 and and CC cord-005453-4057qib7 5462 37 chronic chronic JJ cord-005453-4057qib7 5462 38 GvHD GvHD NNP cord-005453-4057qib7 5462 39 . . . cord-005453-4057qib7 5463 1 We -PRON- PRP cord-005453-4057qib7 5463 2 postulate postulate VBP cord-005453-4057qib7 5463 3 that that IN cord-005453-4057qib7 5463 4 higher high JJR cord-005453-4057qib7 5463 5 target target NN cord-005453-4057qib7 5463 6 CsA csa NN cord-005453-4057qib7 5463 7 levels level NNS cord-005453-4057qib7 5463 8 > > NFP cord-005453-4057qib7 5463 9 200μg 200μg NNP cord-005453-4057qib7 5463 10 / / SYM cord-005453-4057qib7 5463 11 L L NNP cord-005453-4057qib7 5463 12 will will MD cord-005453-4057qib7 5463 13 result result VB cord-005453-4057qib7 5463 14 in in IN cord-005453-4057qib7 5463 15 a a DT cord-005453-4057qib7 5463 16 lower low JJR cord-005453-4057qib7 5463 17 incidence incidence NN cord-005453-4057qib7 5463 18 rate rate NN cord-005453-4057qib7 5463 19 especially especially RB cord-005453-4057qib7 5463 20 of of IN cord-005453-4057qib7 5463 21 aGvHD agvhd NN cord-005453-4057qib7 5463 22 after after IN cord-005453-4057qib7 5463 23 allo allo NN cord-005453-4057qib7 5463 24 - - HYPH cord-005453-4057qib7 5463 25 HSCT HSCT NNP cord-005453-4057qib7 5463 26 . . . cord-005453-4057qib7 5464 1 Results result NNS cord-005453-4057qib7 5464 2 : : : cord-005453-4057qib7 5465 1 We -PRON- PRP cord-005453-4057qib7 5465 2 assessed assess VBD cord-005453-4057qib7 5465 3 660 660 CD cord-005453-4057qib7 5465 4 patients patient NNS cord-005453-4057qib7 5465 5 with with IN cord-005453-4057qib7 5465 6 either either CC cord-005453-4057qib7 5465 7 AML AML NNP cord-005453-4057qib7 5465 8 n=248 n=248 NNP cord-005453-4057qib7 5465 9 , , , cord-005453-4057qib7 5465 10 lymphoma lymphoma NN cord-005453-4057qib7 5465 11 / / SYM cord-005453-4057qib7 5465 12 myeloma myeloma NN cord-005453-4057qib7 5466 1 n=127 n=127 NNP cord-005453-4057qib7 5466 2 , , , cord-005453-4057qib7 5466 3 MDS MDS NNP cord-005453-4057qib7 5466 4 / / SYM cord-005453-4057qib7 5466 5 MPN MPN NNP cord-005453-4057qib7 5466 6 n=124 n=124 NNP cord-005453-4057qib7 5466 7 , , , cord-005453-4057qib7 5467 1 ALL all DT cord-005453-4057qib7 5467 2 n=79 n=79 RB cord-005453-4057qib7 5467 3 , , , cord-005453-4057qib7 5467 4 CLL CLL NNP cord-005453-4057qib7 5467 5 n=36 n=36 NNS cord-005453-4057qib7 5467 6 , , , cord-005453-4057qib7 5467 7 CML CML NNP cord-005453-4057qib7 5467 8 n=23 n=23 NNP cord-005453-4057qib7 5467 9 , , , cord-005453-4057qib7 5467 10 or or CC cord-005453-4057qib7 5467 11 bone bone NN cord-005453-4057qib7 5467 12 marrow marrow NN cord-005453-4057qib7 5467 13 failure failure NN cord-005453-4057qib7 5467 14 n=22 n=22 NNP cord-005453-4057qib7 5467 15 . . . cord-005453-4057qib7 5468 1 In in IN cord-005453-4057qib7 5468 2 patients patient NNS cord-005453-4057qib7 5468 3 with with IN cord-005453-4057qib7 5468 4 clinically clinically RB cord-005453-4057qib7 5468 5 relevant relevant JJ cord-005453-4057qib7 5468 6 aGvHD agvhd NN cord-005453-4057qib7 5468 7 grade grade NN cord-005453-4057qib7 5468 8 ≥2 ≥2 NNP cord-005453-4057qib7 5468 9 , , , cord-005453-4057qib7 5468 10 mean mean VB cord-005453-4057qib7 5468 11 CsA csa NN cord-005453-4057qib7 5468 12 levels level NNS cord-005453-4057qib7 5468 13 was be VBD cord-005453-4057qib7 5468 14 lower low JJR cord-005453-4057qib7 5468 15 on on IN cord-005453-4057qib7 5468 16 day day NN cord-005453-4057qib7 5468 17 0 0 CD cord-005453-4057qib7 5468 18 and and CC cord-005453-4057qib7 5468 19 day day NN cord-005453-4057qib7 5468 20 +10 +10 CD cord-005453-4057qib7 5468 21 ( ( -LRB- cord-005453-4057qib7 5468 22 142±88 142±88 CD cord-005453-4057qib7 5468 23 μg μg NNP cord-005453-4057qib7 5468 24 / / SYM cord-005453-4057qib7 5468 25 L L NNP cord-005453-4057qib7 5468 26 ; ; : cord-005453-4057qib7 5468 27 and and CC cord-005453-4057qib7 5468 28 183±64 183±64 CD cord-005453-4057qib7 5468 29 μg μg NNP cord-005453-4057qib7 5468 30 / / SYM cord-005453-4057qib7 5468 31 L L NNP cord-005453-4057qib7 5468 32 ; ; : cord-005453-4057qib7 5468 33 respectively respectively RB cord-005453-4057qib7 5468 34 ) ) -RRB- cord-005453-4057qib7 5468 35 compared compare VBN cord-005453-4057qib7 5468 36 to to IN cord-005453-4057qib7 5468 37 patients patient NNS cord-005453-4057qib7 5468 38 without without IN cord-005453-4057qib7 5468 39 aGvHD agvhd NN cord-005453-4057qib7 5468 40 ( ( -LRB- cord-005453-4057qib7 5468 41 156±81 156±81 CD cord-005453-4057qib7 5468 42 μg μg NNP cord-005453-4057qib7 5468 43 / / SYM cord-005453-4057qib7 5468 44 L L NNP cord-005453-4057qib7 5468 45 ; ; : cord-005453-4057qib7 5468 46 and and CC cord-005453-4057qib7 5468 47 207±67 207±67 CD cord-005453-4057qib7 5468 48 μg μg NNP cord-005453-4057qib7 5468 49 / / SYM cord-005453-4057qib7 5468 50 L L NNP cord-005453-4057qib7 5468 51 ; ; : cord-005453-4057qib7 5468 52 respectively respectively RB cord-005453-4057qib7 5468 53 ; ; : cord-005453-4057qib7 5468 54 day day NN cord-005453-4057qib7 5468 55 0 0 CD cord-005453-4057qib7 5468 56 : : : cord-005453-4057qib7 5468 57 p=0.003 p=0.003 NNP cord-005453-4057qib7 5468 58 ; ; : cord-005453-4057qib7 5468 59 day day NN cord-005453-4057qib7 5468 60 +10 +10 CD cord-005453-4057qib7 5468 61 : : : cord-005453-4057qib7 5469 1 p=7.57 p=7.57 NN cord-005453-4057qib7 5469 2 x x NN cord-005453-4057qib7 5469 3 10 10 CD cord-005453-4057qib7 5469 4 -9 -9 NNP cord-005453-4057qib7 5469 5 ) ) -RRB- cord-005453-4057qib7 5469 6 . . . cord-005453-4057qib7 5470 1 In in IN cord-005453-4057qib7 5470 2 patients patient NNS cord-005453-4057qib7 5470 3 with with IN cord-005453-4057qib7 5470 4 CsA csa NN cord-005453-4057qib7 5470 5 level level NN cord-005453-4057qib7 5470 6 < < XX cord-005453-4057qib7 5471 1 200 200 CD cord-005453-4057qib7 5471 2 μg μg NNP cord-005453-4057qib7 5471 3 / / SYM cord-005453-4057qib7 5471 4 L L NNP cord-005453-4057qib7 5471 5 , , , cord-005453-4057qib7 5471 6 the the DT cord-005453-4057qib7 5471 7 incidence incidence NN cord-005453-4057qib7 5471 8 of of IN cord-005453-4057qib7 5471 9 aGvHD agvhd NN cord-005453-4057qib7 5471 10 was be VBD cord-005453-4057qib7 5471 11 significantly significantly RB cord-005453-4057qib7 5471 12 more more RBR cord-005453-4057qib7 5471 13 frequent frequent JJ cord-005453-4057qib7 5471 14 compared compare VBN cord-005453-4057qib7 5471 15 to to IN cord-005453-4057qib7 5471 16 patients patient NNS cord-005453-4057qib7 5471 17 with with IN cord-005453-4057qib7 5471 18 CsA csa NN cord-005453-4057qib7 5471 19 levels level NNS cord-005453-4057qib7 5471 20 > > XX cord-005453-4057qib7 5472 1 200 200 CD cord-005453-4057qib7 5472 2 μg μg NNP cord-005453-4057qib7 5472 3 / / SYM cord-005453-4057qib7 5472 4 L L NNP cord-005453-4057qib7 5472 5 [ [ -LRB- cord-005453-4057qib7 5472 6 ( ( -LRB- cord-005453-4057qib7 5472 7 234/356 234/356 CD cord-005453-4057qib7 5472 8 ; ; : cord-005453-4057qib7 5472 9 66 66 CD cord-005453-4057qib7 5472 10 % % NN cord-005453-4057qib7 5472 11 ) ) -RRB- cord-005453-4057qib7 5473 1 versus versus IN cord-005453-4057qib7 5473 2 91/248 91/248 CD cord-005453-4057qib7 5473 3 ( ( -LRB- cord-005453-4057qib7 5473 4 37 37 CD cord-005453-4057qib7 5473 5 % % NN cord-005453-4057qib7 5473 6 ) ) -RRB- cord-005453-4057qib7 5473 7 ; ; : cord-005453-4057qib7 5473 8 p= p= NN cord-005453-4057qib7 5473 9 1.34 1.34 CD cord-005453-4057qib7 5473 10 x x SYM cord-005453-4057qib7 5473 11 10 10 CD cord-005453-4057qib7 5473 12 -12 -12 CD cord-005453-4057qib7 5473 13 ] ] -RRB- cord-005453-4057qib7 5473 14 . . . cord-005453-4057qib7 5474 1 In in IN cord-005453-4057qib7 5474 2 patients patient NNS cord-005453-4057qib7 5474 3 with with IN cord-005453-4057qib7 5474 4 cGvHD cGvHD NNP cord-005453-4057qib7 5474 5 , , , cord-005453-4057qib7 5474 6 there there EX cord-005453-4057qib7 5474 7 was be VBD cord-005453-4057qib7 5474 8 no no DT cord-005453-4057qib7 5474 9 significant significant JJ cord-005453-4057qib7 5474 10 difference difference NN cord-005453-4057qib7 5474 11 between between IN cord-005453-4057qib7 5474 12 CsA csa NN cord-005453-4057qib7 5474 13 levels level NNS cord-005453-4057qib7 5474 14 < < XX cord-005453-4057qib7 5475 1 200 200 CD cord-005453-4057qib7 5475 2 μg μg NNP cord-005453-4057qib7 5475 3 / / SYM cord-005453-4057qib7 5475 4 L L NNP cord-005453-4057qib7 5475 5 ( ( -LRB- cord-005453-4057qib7 5475 6 128/330 128/330 NNP cord-005453-4057qib7 5475 7 ) ) -RRB- cord-005453-4057qib7 5475 8 compared compare VBN cord-005453-4057qib7 5475 9 to to IN cord-005453-4057qib7 5475 10 CsA csa NN cord-005453-4057qib7 5475 11 levels level NNS cord-005453-4057qib7 5475 12 > > XX cord-005453-4057qib7 5475 13 200 200 CD cord-005453-4057qib7 5475 14 μg μg NNP cord-005453-4057qib7 5475 15 / / SYM cord-005453-4057qib7 5475 16 L L NNP cord-005453-4057qib7 5475 17 ( ( -LRB- cord-005453-4057qib7 5475 18 96/ 96/ NN cord-005453-4057qib7 5475 19 233 233 CD cord-005453-4057qib7 5475 20 ; ; : cord-005453-4057qib7 5475 21 p=0.312 p=0.312 NNP cord-005453-4057qib7 5475 22 ) ) -RRB- cord-005453-4057qib7 5475 23 . . . cord-005453-4057qib7 5476 1 The the DT cord-005453-4057qib7 5476 2 optimal optimal JJ cord-005453-4057qib7 5476 3 CsA csa NN cord-005453-4057qib7 5476 4 cut cut VBN cord-005453-4057qib7 5476 5 - - HYPH cord-005453-4057qib7 5476 6 off off RP cord-005453-4057qib7 5476 7 level level NN cord-005453-4057qib7 5476 8 for for IN cord-005453-4057qib7 5476 9 the the DT cord-005453-4057qib7 5476 10 prevention prevention NN cord-005453-4057qib7 5476 11 ( ( -LRB- cord-005453-4057qib7 5476 12 i.e. i.e. FW cord-005453-4057qib7 5476 13 roughly roughly RB cord-005453-4057qib7 5476 14 50 50 CD cord-005453-4057qib7 5476 15 % % NN cord-005453-4057qib7 5476 16 incidence incidence NN cord-005453-4057qib7 5476 17 reduction reduction NN cord-005453-4057qib7 5476 18 ) ) -RRB- cord-005453-4057qib7 5476 19 of of IN cord-005453-4057qib7 5476 20 aGvHD agvhd NN cord-005453-4057qib7 5476 21 was be VBD cord-005453-4057qib7 5476 22 > > NFP cord-005453-4057qib7 5476 23 201 201 CD cord-005453-4057qib7 5476 24 μg μg NNP cord-005453-4057qib7 5476 25 / / SYM cord-005453-4057qib7 5476 26 L l NN cord-005453-4057qib7 5476 27 at at IN cord-005453-4057qib7 5476 28 day day NN cord-005453-4057qib7 5476 29 0 0 NFP cord-005453-4057qib7 5476 30 and and CC cord-005453-4057qib7 5476 31 > > SYM cord-005453-4057qib7 5476 32 195 195 CD cord-005453-4057qib7 5476 33 μg μg NNP cord-005453-4057qib7 5476 34 / / SYM cord-005453-4057qib7 5476 35 L l NN cord-005453-4057qib7 5476 36 at at IN cord-005453-4057qib7 5476 37 day day NN cord-005453-4057qib7 5476 38 +10 +10 CD cord-005453-4057qib7 5477 1 ( ( -LRB- cord-005453-4057qib7 5477 2 Figure figure NN cord-005453-4057qib7 5477 3 1 1 CD cord-005453-4057qib7 5477 4 ) ) -RRB- cord-005453-4057qib7 5478 1 In in IN cord-005453-4057qib7 5478 2 a a DT cord-005453-4057qib7 5478 3 competing compete VBG cord-005453-4057qib7 5478 4 risk risk NN cord-005453-4057qib7 5478 5 analysis analysis NN cord-005453-4057qib7 5478 6 , , , cord-005453-4057qib7 5478 7 time time NN cord-005453-4057qib7 5478 8 to to IN cord-005453-4057qib7 5478 9 aGvHD agvhd NN cord-005453-4057qib7 5478 10 grade grade NN cord-005453-4057qib7 5478 11 ≥2 ≥2 NNP cord-005453-4057qib7 5478 12 ( ( -LRB- cord-005453-4057qib7 5478 13 using use VBG cord-005453-4057qib7 5478 14 death death NN cord-005453-4057qib7 5478 15 of of IN cord-005453-4057qib7 5478 16 other other JJ cord-005453-4057qib7 5478 17 causes cause NNS cord-005453-4057qib7 5478 18 as as IN cord-005453-4057qib7 5478 19 competing compete VBG cord-005453-4057qib7 5478 20 risk risk NN cord-005453-4057qib7 5478 21 ) ) -RRB- cord-005453-4057qib7 5478 22 was be VBD cord-005453-4057qib7 5478 23 associated associate VBN cord-005453-4057qib7 5478 24 with with IN cord-005453-4057qib7 5478 25 CsA csa NN cord-005453-4057qib7 5478 26 levels level NNS cord-005453-4057qib7 5478 27 > > XX cord-005453-4057qib7 5479 1 200 200 CD cord-005453-4057qib7 5479 2 μg μg NNP cord-005453-4057qib7 5479 3 / / SYM cord-005453-4057qib7 5479 4 L L NNP cord-005453-4057qib7 5479 5 on on IN cord-005453-4057qib7 5479 6 day day NN cord-005453-4057qib7 5479 7 0 0 CD cord-005453-4057qib7 5479 8 and and CC cord-005453-4057qib7 5479 9 on on IN cord-005453-4057qib7 5479 10 day day NN cord-005453-4057qib7 5479 11 10 10 CD cord-005453-4057qib7 5479 12 , , , cord-005453-4057qib7 5479 13 unrelated unrelated JJ cord-005453-4057qib7 5479 14 donors donor NNS cord-005453-4057qib7 5479 15 , , , cord-005453-4057qib7 5479 16 myeloablative myeloablative NNP cord-005453-4057qib7 5479 17 conditioning conditioning NN cord-005453-4057qib7 5479 18 ( ( -LRB- cord-005453-4057qib7 5479 19 MAC MAC NNP cord-005453-4057qib7 5479 20 ) ) -RRB- cord-005453-4057qib7 5479 21 , , , cord-005453-4057qib7 5479 22 and and CC cord-005453-4057qib7 5479 23 for for IN cord-005453-4057qib7 5479 24 the the DT cord-005453-4057qib7 5479 25 diagnosis diagnosis NN cord-005453-4057qib7 5479 26 lymphoma lymphoma NN cord-005453-4057qib7 5479 27 / / SYM cord-005453-4057qib7 5479 28 myeloma myeloma NN cord-005453-4057qib7 5479 29 . . . cord-005453-4057qib7 5480 1 Conclusions conclusion NNS cord-005453-4057qib7 5480 2 : : : cord-005453-4057qib7 5481 1 Our -PRON- PRP$ cord-005453-4057qib7 5481 2 data data NN cord-005453-4057qib7 5481 3 support support VBP cord-005453-4057qib7 5481 4 close close JJ cord-005453-4057qib7 5481 5 monitoring monitoring NN cord-005453-4057qib7 5481 6 with with IN cord-005453-4057qib7 5481 7 active active JJ cord-005453-4057qib7 5481 8 adjustments adjustment NNS cord-005453-4057qib7 5481 9 of of IN cord-005453-4057qib7 5481 10 CsA csa NN cord-005453-4057qib7 5481 11 dosing dosing NN cord-005453-4057qib7 5481 12 to to TO cord-005453-4057qib7 5481 13 maintain maintain VB cord-005453-4057qib7 5481 14 therapeutic therapeutic JJ cord-005453-4057qib7 5481 15 CsA csa NN cord-005453-4057qib7 5481 16 levels level NNS cord-005453-4057qib7 5481 17 above above IN cord-005453-4057qib7 5481 18 195 195 CD cord-005453-4057qib7 5481 19 μg μg NNP cord-005453-4057qib7 5481 20 / / SYM cord-005453-4057qib7 5481 21 L L NNP cord-005453-4057qib7 5481 22 in in IN cord-005453-4057qib7 5481 23 the the DT cord-005453-4057qib7 5481 24 first first JJ cord-005453-4057qib7 5481 25 10 10 CD cord-005453-4057qib7 5481 26 days day NNS cord-005453-4057qib7 5481 27 of of IN cord-005453-4057qib7 5481 28 allo allo NN cord-005453-4057qib7 5481 29 - - HYPH cord-005453-4057qib7 5481 30 HCST HCST NNP cord-005453-4057qib7 5481 31 to to TO cord-005453-4057qib7 5481 32 reduce reduce VB cord-005453-4057qib7 5481 33 aGvHD agvhd NN cord-005453-4057qib7 5481 34 . . . cord-005453-4057qib7 5482 1 Disclosure disclosure NN cord-005453-4057qib7 5482 2 : : : cord-005453-4057qib7 5483 1 Noting note VBG cord-005453-4057qib7 5483 2 to to TO cord-005453-4057qib7 5483 3 declare declare VB cord-005453-4057qib7 5483 4 . . . cord-005453-4057qib7 5484 1 Liposomal Liposomal NNP cord-005453-4057qib7 5484 2 cyclosporine cyclosporine NN cord-005453-4057qib7 5485 1 a a LS cord-005453-4057qib7 5485 2 for for IN cord-005453-4057qib7 5485 3 inhalation inhalation NN cord-005453-4057qib7 5485 4 ( ( -LRB- cord-005453-4057qib7 5485 5 L L NNP cord-005453-4057qib7 5485 6 - - HYPH cord-005453-4057qib7 5485 7 CSA CSA NNP cord-005453-4057qib7 5485 8 - - HYPH cord-005453-4057qib7 5485 9 I I NNP cord-005453-4057qib7 5485 10 ) ) -RRB- cord-005453-4057qib7 5486 1 to to TO cord-005453-4057qib7 5486 2 treat treat VB cord-005453-4057qib7 5486 3 bronchiolitis bronchiolitis NNP cord-005453-4057qib7 5486 4 obliterans obliterans NNP cord-005453-4057qib7 5486 5 syndrome syndrome NN cord-005453-4057qib7 5486 6 : : : cord-005453-4057qib7 5486 7 Novel novel JJ cord-005453-4057qib7 5486 8 formulation formulation NN cord-005453-4057qib7 5486 9 with with IN cord-005453-4057qib7 5486 10 therapeutic therapeutic JJ cord-005453-4057qib7 5486 11 potential potential NN cord-005453-4057qib7 5486 12 for for IN cord-005453-4057qib7 5486 13 patients patient NNS cord-005453-4057qib7 5486 14 with with IN cord-005453-4057qib7 5486 15 BOS BOS NNP cord-005453-4057qib7 5486 16 following follow VBG cord-005453-4057qib7 5486 17 allo allo NN cord-005453-4057qib7 5486 18 - - HYPH cord-005453-4057qib7 5486 19 HSCT HSCT NNP cord-005453-4057qib7 5486 20 Noreen Noreen NNP cord-005453-4057qib7 5486 21 Roth Roth NNP cord-005453-4057qib7 5486 22 Henig Henig NNP cord-005453-4057qib7 5486 23 1 1 CD cord-005453-4057qib7 5486 24 , , , cord-005453-4057qib7 5486 25 Emilie Emilie NNP cord-005453-4057qib7 5486 26 Hofstetter Hofstetter NNP cord-005453-4057qib7 5486 27 2 2 CD cord-005453-4057qib7 5486 28 , , , cord-005453-4057qib7 5486 29 Dominik Dominik NNP cord-005453-4057qib7 5486 30 Kappeler Kappeler NNP cord-005453-4057qib7 5486 31 3 3 CD cord-005453-4057qib7 5486 32 , , , cord-005453-4057qib7 5486 33 Gerhard Gerhard NNP cord-005453-4057qib7 5486 34 Boerner Boerner NNP cord-005453-4057qib7 5486 35 3 3 CD cord-005453-4057qib7 5486 36 Background Background NNP cord-005453-4057qib7 5486 37 : : : cord-005453-4057qib7 5487 1 Bronchiolitis Bronchiolitis NNP cord-005453-4057qib7 5487 2 obliterans obliterans NNP cord-005453-4057qib7 5487 3 syndrome syndrome NN cord-005453-4057qib7 5487 4 ( ( -LRB- cord-005453-4057qib7 5487 5 BOS BOS NNP cord-005453-4057qib7 5487 6 ) ) -RRB- cord-005453-4057qib7 5487 7 is be VBZ cord-005453-4057qib7 5487 8 a a DT cord-005453-4057qib7 5487 9 rapidly rapidly RB cord-005453-4057qib7 5487 10 progressive progressive JJ cord-005453-4057qib7 5487 11 lung lung NN cord-005453-4057qib7 5487 12 disease disease NN cord-005453-4057qib7 5487 13 caused cause VBN cord-005453-4057qib7 5487 14 by by IN cord-005453-4057qib7 5487 15 T t NN cord-005453-4057qib7 5487 16 - - HYPH cord-005453-4057qib7 5487 17 cell cell NN cord-005453-4057qib7 5487 18 mediated mediate VBN cord-005453-4057qib7 5487 19 inflammation inflammation NN cord-005453-4057qib7 5487 20 that that WDT cord-005453-4057qib7 5487 21 leads lead VBZ cord-005453-4057qib7 5487 22 to to IN cord-005453-4057qib7 5487 23 blockage blockage NN cord-005453-4057qib7 5487 24 of of IN cord-005453-4057qib7 5487 25 bronchioles bronchiole NNS cord-005453-4057qib7 5487 26 , , , cord-005453-4057qib7 5487 27 leading lead VBG cord-005453-4057qib7 5487 28 to to IN cord-005453-4057qib7 5487 29 respiratory respiratory JJ cord-005453-4057qib7 5487 30 failure failure NN cord-005453-4057qib7 5487 31 and and CC cord-005453-4057qib7 5487 32 death death NN cord-005453-4057qib7 5487 33 shortly shortly RB cord-005453-4057qib7 5487 34 after after IN cord-005453-4057qib7 5487 35 diagnosis diagnosis NN cord-005453-4057qib7 5487 36 . . . cord-005453-4057qib7 5488 1 Approximately approximately RB cord-005453-4057qib7 5488 2 4 4 CD cord-005453-4057qib7 5488 3 % % NN cord-005453-4057qib7 5488 4 to to TO cord-005453-4057qib7 5488 5 10 10 CD cord-005453-4057qib7 5488 6 % % NN cord-005453-4057qib7 5488 7 of of IN cord-005453-4057qib7 5488 8 patients patient NNS cord-005453-4057qib7 5488 9 who who WP cord-005453-4057qib7 5488 10 undergo undergo VBP cord-005453-4057qib7 5488 11 allogeneic allogeneic IN cord-005453-4057qib7 5488 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 5488 13 stem stem NN cord-005453-4057qib7 5488 14 cell cell NN cord-005453-4057qib7 5488 15 transplant transplant NN cord-005453-4057qib7 5488 16 ( ( -LRB- cord-005453-4057qib7 5488 17 allo allo NN cord-005453-4057qib7 5488 18 - - HYPH cord-005453-4057qib7 5488 19 HSCT HSCT NNP cord-005453-4057qib7 5488 20 ) ) -RRB- cord-005453-4057qib7 5488 21 will will MD cord-005453-4057qib7 5488 22 develop develop VB cord-005453-4057qib7 5488 23 BOS BOS NNP cord-005453-4057qib7 5488 24 , , , cord-005453-4057qib7 5488 25 with with IN cord-005453-4057qib7 5488 26 72 72 CD cord-005453-4057qib7 5488 27 - - SYM cord-005453-4057qib7 5488 28 100 100 CD cord-005453-4057qib7 5488 29 % % NN cord-005453-4057qib7 5488 30 developing develop VBG cord-005453-4057qib7 5488 31 BOS BOS NNP cord-005453-4057qib7 5488 32 as as IN cord-005453-4057qib7 5488 33 a a DT cord-005453-4057qib7 5488 34 respiratory respiratory JJ cord-005453-4057qib7 5488 35 form form NN cord-005453-4057qib7 5488 36 chronic chronic JJ cord-005453-4057qib7 5488 37 graft graft NN cord-005453-4057qib7 5488 38 - - HYPH cord-005453-4057qib7 5488 39 vs vs IN cord-005453-4057qib7 5488 40 - - HYPH cord-005453-4057qib7 5488 41 host host NN cord-005453-4057qib7 5488 42 disease disease NN cord-005453-4057qib7 5488 43 ( ( -LRB- cord-005453-4057qib7 5488 44 cGVHD cGVHD NNP cord-005453-4057qib7 5488 45 ) ) -RRB- cord-005453-4057qib7 5488 46 in in IN cord-005453-4057qib7 5488 47 addition addition NN cord-005453-4057qib7 5488 48 to to IN cord-005453-4057qib7 5488 49 other other JJ cord-005453-4057qib7 5488 50 signs sign NNS cord-005453-4057qib7 5488 51 of of IN cord-005453-4057qib7 5488 52 cGVHD cGVHD NNP cord-005453-4057qib7 5488 53 . . . cord-005453-4057qib7 5489 1 Mean mean JJ cord-005453-4057qib7 5489 2 time time NN cord-005453-4057qib7 5489 3 to to IN cord-005453-4057qib7 5489 4 BOS BOS NNP cord-005453-4057qib7 5489 5 diagnosis diagnosis NN cord-005453-4057qib7 5489 6 ranges range VBZ cord-005453-4057qib7 5489 7 from from IN cord-005453-4057qib7 5489 8 273 273 CD cord-005453-4057qib7 5489 9 to to TO cord-005453-4057qib7 5489 10 547 547 CD cord-005453-4057qib7 5489 11 days day NNS cord-005453-4057qib7 5489 12 post post NN cord-005453-4057qib7 5489 13 - - NN cord-005453-4057qib7 5489 14 transplant transplant NN cord-005453-4057qib7 5489 15 . . . cord-005453-4057qib7 5490 1 The the DT cord-005453-4057qib7 5490 2 histopathology histopathology NN cord-005453-4057qib7 5490 3 of of IN cord-005453-4057qib7 5490 4 BOS BOS NNP cord-005453-4057qib7 5490 5 after after IN cord-005453-4057qib7 5490 6 allo allo NN cord-005453-4057qib7 5490 7 - - HYPH cord-005453-4057qib7 5490 8 HSCT HSCT NNP cord-005453-4057qib7 5490 9 and and CC cord-005453-4057qib7 5490 10 lung lung NN cord-005453-4057qib7 5490 11 transplantation transplantation NN cord-005453-4057qib7 5490 12 is be VBZ cord-005453-4057qib7 5490 13 identical identical JJ cord-005453-4057qib7 5490 14 . . . cord-005453-4057qib7 5491 1 Early early JJ cord-005453-4057qib7 5491 2 studies study NNS cord-005453-4057qib7 5491 3 of of IN cord-005453-4057qib7 5491 4 L L NNP cord-005453-4057qib7 5491 5 - - HYPH cord-005453-4057qib7 5491 6 CsA CsA NNP cord-005453-4057qib7 5491 7 - - : cord-005453-4057qib7 5491 8 i i NNP cord-005453-4057qib7 5491 9 for for IN cord-005453-4057qib7 5491 10 the the DT cord-005453-4057qib7 5491 11 prevention prevention NN cord-005453-4057qib7 5491 12 of of IN cord-005453-4057qib7 5491 13 BOS BOS NNP cord-005453-4057qib7 5491 14 in in IN cord-005453-4057qib7 5491 15 lung lung NN cord-005453-4057qib7 5491 16 transplant transplant NN cord-005453-4057qib7 5491 17 recipients recipient NNS cord-005453-4057qib7 5491 18 demonstrated demonstrate VBD cord-005453-4057qib7 5491 19 therapeutic therapeutic JJ cord-005453-4057qib7 5491 20 benefit benefit NN cord-005453-4057qib7 5491 21 . . . cord-005453-4057qib7 5492 1 L l NN cord-005453-4057qib7 5492 2 - - HYPH cord-005453-4057qib7 5492 3 CsA CsA NNP cord-005453-4057qib7 5493 1 -i -i NNP cord-005453-4057qib7 5493 2 is be VBZ cord-005453-4057qib7 5493 3 a a DT cord-005453-4057qib7 5493 4 novel novel NN cord-005453-4057qib7 5493 5 , , , cord-005453-4057qib7 5493 6 liposomal liposomal IN cord-005453-4057qib7 5493 7 formulation formulation NN cord-005453-4057qib7 5493 8 of of IN cord-005453-4057qib7 5493 9 cyclosporine cyclosporine NN cord-005453-4057qib7 5493 10 administered administer VBN cord-005453-4057qib7 5493 11 via via IN cord-005453-4057qib7 5493 12 a a DT cord-005453-4057qib7 5493 13 PARI PARI NNP cord-005453-4057qib7 5493 14 investigational investigational JJ cord-005453-4057qib7 5493 15 eFlow eflow NN cord-005453-4057qib7 5493 16 â â CD cord-005453-4057qib7 5493 17 nebulizer nebulizer NN cord-005453-4057qib7 5493 18 which which WDT cord-005453-4057qib7 5493 19 delivers deliver VBZ cord-005453-4057qib7 5493 20 a a DT cord-005453-4057qib7 5493 21 potent potent JJ cord-005453-4057qib7 5493 22 immunosuppressant immunosuppressant RB cord-005453-4057qib7 5493 23 to to IN cord-005453-4057qib7 5493 24 the the DT cord-005453-4057qib7 5493 25 site site NN cord-005453-4057qib7 5493 26 of of IN cord-005453-4057qib7 5493 27 disease disease NN cord-005453-4057qib7 5493 28 . . . cord-005453-4057qib7 5494 1 Pharmacokinetics pharmacokinetic NNS cord-005453-4057qib7 5494 2 and and CC cord-005453-4057qib7 5494 3 tolerability tolerability NN cord-005453-4057qib7 5494 4 of of IN cord-005453-4057qib7 5494 5 L l NN cord-005453-4057qib7 5494 6 - - HYPH cord-005453-4057qib7 5494 7 CsA CsA NNP cord-005453-4057qib7 5494 8 - - : cord-005453-4057qib7 5494 9 i i PRP cord-005453-4057qib7 5494 10 is be VBZ cord-005453-4057qib7 5494 11 presented present VBN cord-005453-4057qib7 5494 12 . . . cord-005453-4057qib7 5495 1 Methods method NNS cord-005453-4057qib7 5495 2 : : : cord-005453-4057qib7 5496 1 Retrospective retrospective JJ cord-005453-4057qib7 5496 2 review review NN cord-005453-4057qib7 5496 3 of of IN cord-005453-4057qib7 5496 4 two two CD cord-005453-4057qib7 5496 5 clinical clinical JJ cord-005453-4057qib7 5496 6 studies study NNS cord-005453-4057qib7 5496 7 of of IN cord-005453-4057qib7 5496 8 L L NNP cord-005453-4057qib7 5496 9 - - HYPH cord-005453-4057qib7 5496 10 CsA CsA NNP cord-005453-4057qib7 5496 11 - - : cord-005453-4057qib7 5496 12 i i NNP cord-005453-4057qib7 5496 13 ( ( -LRB- cord-005453-4057qib7 5496 14 isotonic isotonic JJ cord-005453-4057qib7 5496 15 , , , cord-005453-4057qib7 5496 16 4mg 4mg JJ cord-005453-4057qib7 5496 17 / / SYM cord-005453-4057qib7 5496 18 mL ml NN cord-005453-4057qib7 5496 19 ) ) -RRB- cord-005453-4057qib7 5496 20 for for IN cord-005453-4057qib7 5496 21 BOS BOS NNP cord-005453-4057qib7 5496 22 associated associate VBN cord-005453-4057qib7 5496 23 with with IN cord-005453-4057qib7 5496 24 lung lung NN cord-005453-4057qib7 5496 25 transplantation transplantation NN cord-005453-4057qib7 5496 26 . . . cord-005453-4057qib7 5497 1 Both both DT cord-005453-4057qib7 5497 2 studies study NNS cord-005453-4057qib7 5497 3 had have VBD cord-005453-4057qib7 5497 4 a a DT cord-005453-4057qib7 5497 5 control control NN cord-005453-4057qib7 5497 6 arm arm NN cord-005453-4057qib7 5497 7 and and CC cord-005453-4057qib7 5497 8 results result NNS cord-005453-4057qib7 5497 9 reported report VBN cord-005453-4057qib7 5497 10 here here RB cord-005453-4057qib7 5497 11 are be VBP cord-005453-4057qib7 5497 12 for for IN cord-005453-4057qib7 5497 13 patients patient NNS cord-005453-4057qib7 5497 14 who who WP cord-005453-4057qib7 5497 15 received receive VBD cord-005453-4057qib7 5497 16 L l NN cord-005453-4057qib7 5497 17 - - HYPH cord-005453-4057qib7 5497 18 CsA CsA NNP cord-005453-4057qib7 5497 19 - - : cord-005453-4057qib7 5497 20 i i PRP cord-005453-4057qib7 5497 21 . . . cord-005453-4057qib7 5498 1 Subjects subject NNS cord-005453-4057qib7 5498 2 received receive VBD cord-005453-4057qib7 5498 3 5 5 CD cord-005453-4057qib7 5498 4 mg mg NN cord-005453-4057qib7 5498 5 ( ( -LRB- cord-005453-4057qib7 5498 6 single single JJ cord-005453-4057qib7 5498 7 lung lung NN cord-005453-4057qib7 5498 8 transplant transplant NN cord-005453-4057qib7 5498 9 ) ) -RRB- cord-005453-4057qib7 5498 10 and and CC cord-005453-4057qib7 5498 11 10 10 CD cord-005453-4057qib7 5498 12 mg mg NNS cord-005453-4057qib7 5498 13 ( ( -LRB- cord-005453-4057qib7 5498 14 double double JJ cord-005453-4057qib7 5498 15 lung lung NN cord-005453-4057qib7 5498 16 transplant transplant NN cord-005453-4057qib7 5498 17 ) ) -RRB- cord-005453-4057qib7 5498 18 bid bid VBD cord-005453-4057qib7 5498 19 via via IN cord-005453-4057qib7 5498 20 inhalation inhalation NN cord-005453-4057qib7 5498 21 . . . cord-005453-4057qib7 5499 1 Blood blood NN cord-005453-4057qib7 5499 2 samples sample NNS cord-005453-4057qib7 5499 3 for for IN cord-005453-4057qib7 5499 4 pharmacokinetic pharmacokinetic JJ cord-005453-4057qib7 5499 5 analysis analysis NN cord-005453-4057qib7 5499 6 of of IN cord-005453-4057qib7 5499 7 cyclosporine cyclosporine NN cord-005453-4057qib7 5499 8 A a DT cord-005453-4057qib7 5499 9 concentrations concentration NNS cord-005453-4057qib7 5499 10 were be VBD cord-005453-4057qib7 5499 11 collected collect VBN cord-005453-4057qib7 5499 12 before before IN cord-005453-4057qib7 5499 13 inhalation inhalation NN cord-005453-4057qib7 5499 14 , , , cord-005453-4057qib7 5499 15 immediately immediately RB cord-005453-4057qib7 5499 16 after after IN cord-005453-4057qib7 5499 17 inhalation inhalation NN cord-005453-4057qib7 5499 18 , , , cord-005453-4057qib7 5499 19 and and CC cord-005453-4057qib7 5499 20 thereafter thereafter RB cord-005453-4057qib7 5499 21 in in IN cord-005453-4057qib7 5499 22 intervals interval NNS cord-005453-4057qib7 5499 23 of of IN cord-005453-4057qib7 5499 24 15 15 CD cord-005453-4057qib7 5499 25 , , , cord-005453-4057qib7 5499 26 30 30 CD cord-005453-4057qib7 5499 27 , , , cord-005453-4057qib7 5499 28 60 60 CD cord-005453-4057qib7 5499 29 min min NN cord-005453-4057qib7 5499 30 and and CC cord-005453-4057qib7 5499 31 2 2 CD cord-005453-4057qib7 5499 32 , , , cord-005453-4057qib7 5499 33 4 4 CD cord-005453-4057qib7 5499 34 , , , cord-005453-4057qib7 5499 35 8 8 CD cord-005453-4057qib7 5499 36 and and CC cord-005453-4057qib7 5499 37 12 12 CD cord-005453-4057qib7 5499 38 hours hour NNS cord-005453-4057qib7 5499 39 . . . cord-005453-4057qib7 5500 1 Local local JJ cord-005453-4057qib7 5500 2 and and CC cord-005453-4057qib7 5500 3 general general JJ cord-005453-4057qib7 5500 4 tolerability tolerability NN cord-005453-4057qib7 5500 5 of of IN cord-005453-4057qib7 5500 6 L L NNP cord-005453-4057qib7 5500 7 - - HYPH cord-005453-4057qib7 5500 8 CsA CsA NNP cord-005453-4057qib7 5501 1 -i -i NNP cord-005453-4057qib7 5501 2 was be VBD cord-005453-4057qib7 5501 3 investigated investigate VBN cord-005453-4057qib7 5501 4 . . . cord-005453-4057qib7 5502 1 Results result NNS cord-005453-4057qib7 5502 2 : : : cord-005453-4057qib7 5503 1 Between between IN cord-005453-4057qib7 5503 2 the the DT cord-005453-4057qib7 5503 3 two two CD cord-005453-4057qib7 5503 4 studies study NNS cord-005453-4057qib7 5503 5 , , , cord-005453-4057qib7 5503 6 85 85 CD cord-005453-4057qib7 5503 7 subjects subject NNS cord-005453-4057qib7 5503 8 received receive VBD cord-005453-4057qib7 5503 9 either either CC cord-005453-4057qib7 5503 10 5 5 CD cord-005453-4057qib7 5503 11 or or CC cord-005453-4057qib7 5503 12 10 10 CD cord-005453-4057qib7 5503 13 mg mg NN cord-005453-4057qib7 5503 14 bid bid NN cord-005453-4057qib7 5503 15 of of IN cord-005453-4057qib7 5503 16 L l NN cord-005453-4057qib7 5503 17 - - HYPH cord-005453-4057qib7 5503 18 CsA CsA NNP cord-005453-4057qib7 5503 19 - - : cord-005453-4057qib7 5503 20 i i PRP cord-005453-4057qib7 5503 21 . . . cord-005453-4057qib7 5504 1 Pharmacokinetic pharmacokinetic JJ cord-005453-4057qib7 5504 2 models model NNS cord-005453-4057qib7 5504 3 predict predict VBP cord-005453-4057qib7 5504 4 a a DT cord-005453-4057qib7 5504 5 constant constant JJ cord-005453-4057qib7 5504 6 drug drug NN cord-005453-4057qib7 5504 7 level level NN cord-005453-4057qib7 5504 8 in in IN cord-005453-4057qib7 5504 9 the the DT cord-005453-4057qib7 5504 10 lung lung NN cord-005453-4057qib7 5504 11 . . . cord-005453-4057qib7 5505 1 Maximum maximum JJ cord-005453-4057qib7 5505 2 serum serum NN cord-005453-4057qib7 5505 3 cyclosporine cyclosporine IN cord-005453-4057qib7 5505 4 A a DT cord-005453-4057qib7 5505 5 concentration concentration NN cord-005453-4057qib7 5505 6 after after IN cord-005453-4057qib7 5505 7 inhalation inhalation NN cord-005453-4057qib7 5505 8 was be VBD cord-005453-4057qib7 5505 9 57.42 57.42 CD cord-005453-4057qib7 5505 10 ± ± CD cord-005453-4057qib7 5505 11 34.26 34.26 CD cord-005453-4057qib7 5505 12 ng ng NN cord-005453-4057qib7 5505 13 / / SYM cord-005453-4057qib7 5505 14 ml ml NN cord-005453-4057qib7 5505 15 . . . cord-005453-4057qib7 5506 1 Trough trough NN cord-005453-4057qib7 5506 2 levels level NNS cord-005453-4057qib7 5506 3 for for IN cord-005453-4057qib7 5506 4 up up IN cord-005453-4057qib7 5506 5 to to TO cord-005453-4057qib7 5506 6 2-years 2-years CD cord-005453-4057qib7 5506 7 of of IN cord-005453-4057qib7 5506 8 daily daily JJ cord-005453-4057qib7 5506 9 administration administration NN cord-005453-4057qib7 5506 10 was be VBD cord-005453-4057qib7 5506 11 4 4 CD cord-005453-4057qib7 5506 12 - - SYM cord-005453-4057qib7 5506 13 5 5 CD cord-005453-4057qib7 5506 14 ng ng NN cord-005453-4057qib7 5506 15 / / SYM cord-005453-4057qib7 5506 16 ml ml XX cord-005453-4057qib7 5506 17 with with IN cord-005453-4057qib7 5506 18 no no DT cord-005453-4057qib7 5506 19 evidence evidence NN cord-005453-4057qib7 5506 20 of of IN cord-005453-4057qib7 5506 21 accumulation accumulation NN cord-005453-4057qib7 5506 22 following follow VBG cord-005453-4057qib7 5506 23 repeated repeat VBN cord-005453-4057qib7 5506 24 exposure exposure NN cord-005453-4057qib7 5506 25 . . . cord-005453-4057qib7 5507 1 Tolerability tolerability NN cord-005453-4057qib7 5507 2 data datum NNS cord-005453-4057qib7 5507 3 was be VBD cord-005453-4057qib7 5507 4 assessed assess VBN cord-005453-4057qib7 5507 5 from from IN cord-005453-4057qib7 5507 6 1068 1068 CD cord-005453-4057qib7 5507 7 patient patient NN cord-005453-4057qib7 5507 8 - - HYPH cord-005453-4057qib7 5507 9 month month NN cord-005453-4057qib7 5507 10 exposure exposure NN cord-005453-4057qib7 5507 11 to to IN cord-005453-4057qib7 5507 12 L l NN cord-005453-4057qib7 5507 13 - - HYPH cord-005453-4057qib7 5507 14 CsA CsA NNP cord-005453-4057qib7 5507 15 - - : cord-005453-4057qib7 5507 16 i i PRP cord-005453-4057qib7 5507 17 . . . cord-005453-4057qib7 5508 1 Reported report VBN cord-005453-4057qib7 5508 2 symptoms symptom NNS cord-005453-4057qib7 5508 3 were be VBD cord-005453-4057qib7 5508 4 : : : cord-005453-4057qib7 5508 5 pharyngeal pharyngeal JJ cord-005453-4057qib7 5508 6 soreness soreness NN cord-005453-4057qib7 5508 7 1 1 CD cord-005453-4057qib7 5508 8 % % NN cord-005453-4057qib7 5508 9 ; ; : cord-005453-4057qib7 5508 10 cough cough NN cord-005453-4057qib7 5508 11 22 22 CD cord-005453-4057qib7 5508 12 % % NN cord-005453-4057qib7 5508 13 ; ; : cord-005453-4057qib7 5508 14 dyspnoea dyspnoea NNS cord-005453-4057qib7 5508 15 7 7 CD cord-005453-4057qib7 5508 16 % % NN cord-005453-4057qib7 5508 17 ; ; , cord-005453-4057qib7 5508 18 and and CC cord-005453-4057qib7 5508 19 wheezing wheeze VBG cord-005453-4057qib7 5508 20 1 1 CD cord-005453-4057qib7 5508 21 % % NN cord-005453-4057qib7 5508 22 . . . cord-005453-4057qib7 5509 1 No no DT cord-005453-4057qib7 5509 2 subject subject NN cord-005453-4057qib7 5509 3 discontinued discontinue VBD cord-005453-4057qib7 5509 4 due due IN cord-005453-4057qib7 5509 5 to to IN cord-005453-4057qib7 5509 6 intolerability intolerability NN cord-005453-4057qib7 5509 7 . . . cord-005453-4057qib7 5510 1 Inhalation inhalation NN cord-005453-4057qib7 5510 2 time time NN cord-005453-4057qib7 5510 3 is be VBZ cord-005453-4057qib7 5510 4 on on IN cord-005453-4057qib7 5510 5 average average JJ cord-005453-4057qib7 5510 6 9 9 CD cord-005453-4057qib7 5510 7 - - SYM cord-005453-4057qib7 5510 8 13 13 CD cord-005453-4057qib7 5510 9 min min NN cord-005453-4057qib7 5510 10 . . . cord-005453-4057qib7 5511 1 Conclusions conclusion NNS cord-005453-4057qib7 5511 2 : : : cord-005453-4057qib7 5512 1 L l NN cord-005453-4057qib7 5512 2 - - HYPH cord-005453-4057qib7 5512 3 CsA CsA NNP cord-005453-4057qib7 5513 1 -i -i NNP cord-005453-4057qib7 5513 2 provides provide VBZ cord-005453-4057qib7 5513 3 high high JJ cord-005453-4057qib7 5513 4 and and CC cord-005453-4057qib7 5513 5 constant constant JJ cord-005453-4057qib7 5513 6 concentrations concentration NNS cord-005453-4057qib7 5513 7 to to IN cord-005453-4057qib7 5513 8 the the DT cord-005453-4057qib7 5513 9 airways airway NNS cord-005453-4057qib7 5513 10 of of IN cord-005453-4057qib7 5513 11 the the DT cord-005453-4057qib7 5513 12 lungs lung NNS cord-005453-4057qib7 5513 13 and and CC cord-005453-4057qib7 5513 14 the the DT cord-005453-4057qib7 5513 15 site site NN cord-005453-4057qib7 5513 16 of of IN cord-005453-4057qib7 5513 17 BOS BOS NNP cord-005453-4057qib7 5513 18 . . . cord-005453-4057qib7 5514 1 L l NN cord-005453-4057qib7 5514 2 - - HYPH cord-005453-4057qib7 5514 3 CsA CsA NNP cord-005453-4057qib7 5515 1 -i -i NNP cord-005453-4057qib7 5515 2 is be VBZ cord-005453-4057qib7 5515 3 well well RB cord-005453-4057qib7 5515 4 tolerated tolerate VBN cord-005453-4057qib7 5515 5 in in IN cord-005453-4057qib7 5515 6 lung lung NN cord-005453-4057qib7 5515 7 transplant transplant NN cord-005453-4057qib7 5515 8 patients patient NNS cord-005453-4057qib7 5515 9 . . . cord-005453-4057qib7 5516 1 Use Use NNP cord-005453-4057qib7 5516 2 of of IN cord-005453-4057qib7 5516 3 L l NN cord-005453-4057qib7 5516 4 - - HYPH cord-005453-4057qib7 5516 5 CsA CsA NNP cord-005453-4057qib7 5516 6 - - : cord-005453-4057qib7 5516 7 i i PRP cord-005453-4057qib7 5516 8 instead instead RB cord-005453-4057qib7 5516 9 of of IN cord-005453-4057qib7 5516 10 augmentation augmentation NN cord-005453-4057qib7 5516 11 of of IN cord-005453-4057qib7 5516 12 systemic systemic JJ cord-005453-4057qib7 5516 13 CsA csa NN cord-005453-4057qib7 5516 14 reduces reduce VBZ cord-005453-4057qib7 5516 15 the the DT cord-005453-4057qib7 5516 16 total total JJ cord-005453-4057qib7 5516 17 drug drug NN cord-005453-4057qib7 5516 18 exposure exposure NN cord-005453-4057qib7 5516 19 . . . cord-005453-4057qib7 5517 1 A a DT cord-005453-4057qib7 5517 2 multicentre multicentre NNP cord-005453-4057qib7 5517 3 Phase Phase NNP cord-005453-4057qib7 5517 4 2 2 CD cord-005453-4057qib7 5517 5 safety safety NN cord-005453-4057qib7 5517 6 and and CC cord-005453-4057qib7 5517 7 exploratory exploratory JJ cord-005453-4057qib7 5517 8 efficacy efficacy NN cord-005453-4057qib7 5517 9 trial trial NN cord-005453-4057qib7 5517 10 for for IN cord-005453-4057qib7 5517 11 the the DT cord-005453-4057qib7 5517 12 treatment treatment NN cord-005453-4057qib7 5517 13 of of IN cord-005453-4057qib7 5517 14 BOS BOS NNP cord-005453-4057qib7 5517 15 in in IN cord-005453-4057qib7 5517 16 allo allo NN cord-005453-4057qib7 5517 17 - - HYPH cord-005453-4057qib7 5517 18 HSCT HSCT NNP cord-005453-4057qib7 5517 19 recipients recipient NNS cord-005453-4057qib7 5517 20 is be VBZ cord-005453-4057qib7 5517 21 underway underway JJ cord-005453-4057qib7 5517 22 . . . cord-005453-4057qib7 5518 1 Disclosure disclosure NN cord-005453-4057qib7 5518 2 Background background NN cord-005453-4057qib7 5518 3 : : : cord-005453-4057qib7 5518 4 There there EX cord-005453-4057qib7 5518 5 are be VBP cord-005453-4057qib7 5518 6 a a DT cord-005453-4057qib7 5518 7 number number NN cord-005453-4057qib7 5518 8 of of IN cord-005453-4057qib7 5518 9 biomarkers biomarker NNS cord-005453-4057qib7 5518 10 that that WDT cord-005453-4057qib7 5518 11 predict predict VBP cord-005453-4057qib7 5518 12 non non JJ cord-005453-4057qib7 5518 13 - - JJ cord-005453-4057qib7 5518 14 relapse relapse JJ cord-005453-4057qib7 5518 15 mortality mortality NN cord-005453-4057qib7 5518 16 ( ( -LRB- cord-005453-4057qib7 5518 17 NRM NRM NNP cord-005453-4057qib7 5518 18 ) ) -RRB- cord-005453-4057qib7 5518 19 , , , cord-005453-4057qib7 5518 20 graft graft NN cord-005453-4057qib7 5518 21 - - HYPH cord-005453-4057qib7 5518 22 versus versus IN cord-005453-4057qib7 5518 23 - - HYPH cord-005453-4057qib7 5518 24 host host NN cord-005453-4057qib7 5518 25 disease disease NN cord-005453-4057qib7 5518 26 ( ( -LRB- cord-005453-4057qib7 5518 27 GVHD GVHD NNP cord-005453-4057qib7 5518 28 ) ) -RRB- cord-005453-4057qib7 5518 29 and and CC cord-005453-4057qib7 5518 30 relapse relapse NN cord-005453-4057qib7 5518 31 incidence incidence NN cord-005453-4057qib7 5518 32 ( ( -LRB- cord-005453-4057qib7 5518 33 RI RI NNP cord-005453-4057qib7 5518 34 ) ) -RRB- cord-005453-4057qib7 5518 35 after after IN cord-005453-4057qib7 5518 36 conventional conventional JJ cord-005453-4057qib7 5518 37 GVHD GVHD NNP cord-005453-4057qib7 5518 38 prophylaxis prophylaxis NN cord-005453-4057qib7 5518 39 based base VBN cord-005453-4057qib7 5518 40 on on IN cord-005453-4057qib7 5518 41 calcineurin calcineurin NNP cord-005453-4057qib7 5518 42 inhibitors inhibitor NNS cord-005453-4057qib7 5518 43 with with IN cord-005453-4057qib7 5518 44 or or CC cord-005453-4057qib7 5518 45 without without IN cord-005453-4057qib7 5518 46 antithymocyte antithymocyte NNP cord-005453-4057qib7 5518 47 globulin globulin NNP cord-005453-4057qib7 5518 48 . . . cord-005453-4057qib7 5519 1 Currently currently RB cord-005453-4057qib7 5519 2 there there EX cord-005453-4057qib7 5519 3 is be VBZ cord-005453-4057qib7 5519 4 limited limited JJ cord-005453-4057qib7 5519 5 data datum NNS cord-005453-4057qib7 5519 6 whether whether IN cord-005453-4057qib7 5519 7 the the DT cord-005453-4057qib7 5519 8 conventional conventional JJ cord-005453-4057qib7 5519 9 predictive predictive JJ cord-005453-4057qib7 5519 10 biomarkers biomarker NNS cord-005453-4057qib7 5519 11 work work VBP cord-005453-4057qib7 5519 12 with with IN cord-005453-4057qib7 5519 13 posttransplantation posttransplantation NN cord-005453-4057qib7 5519 14 cyclophosphamide cyclophosphamide NNP cord-005453-4057qib7 5519 15 ( ( -LRB- cord-005453-4057qib7 5519 16 PTCy PTCy NNP cord-005453-4057qib7 5519 17 ) ) -RRB- cord-005453-4057qib7 5519 18 prophylaxis prophylaxis NN cord-005453-4057qib7 5519 19 . . . cord-005453-4057qib7 5520 1 Methods method NNS cord-005453-4057qib7 5520 2 : : : cord-005453-4057qib7 5520 3 Prospective prospective JJ cord-005453-4057qib7 5520 4 single single JJ cord-005453-4057qib7 5520 5 - - HYPH cord-005453-4057qib7 5520 6 center center NN cord-005453-4057qib7 5520 7 study study NN cord-005453-4057qib7 5520 8 in in IN cord-005453-4057qib7 5520 9 2015 2015 CD cord-005453-4057qib7 5520 10 - - SYM cord-005453-4057qib7 5520 11 2016 2016 CD cord-005453-4057qib7 5520 12 enrolled enrol VBD cord-005453-4057qib7 5520 13 79 79 CD cord-005453-4057qib7 5520 14 adult adult NN cord-005453-4057qib7 5520 15 patients patient NNS cord-005453-4057qib7 5520 16 with with IN cord-005453-4057qib7 5520 17 acute acute JJ cord-005453-4057qib7 5520 18 leukemia leukemia NN cord-005453-4057qib7 5520 19 in in IN cord-005453-4057qib7 5520 20 CR CR NNP cord-005453-4057qib7 5520 21 ( ( -LRB- cord-005453-4057qib7 5520 22 34 34 CD cord-005453-4057qib7 5520 23 % % NN cord-005453-4057qib7 5520 24 with with IN cord-005453-4057qib7 5520 25 ALL all DT cord-005453-4057qib7 5520 26 , , , cord-005453-4057qib7 5520 27 66 66 CD cord-005453-4057qib7 5520 28 % % NN cord-005453-4057qib7 5520 29 with with IN cord-005453-4057qib7 5520 30 AML AML NNP cord-005453-4057qib7 5520 31 ) ) -RRB- cord-005453-4057qib7 5520 32 . . . cord-005453-4057qib7 5521 1 26 26 CD cord-005453-4057qib7 5521 2 received receive VBD cord-005453-4057qib7 5521 3 matched match VBN cord-005453-4057qib7 5521 4 related related JJ cord-005453-4057qib7 5521 5 bone bone NN cord-005453-4057qib7 5521 6 marrow marrow NN cord-005453-4057qib7 5521 7 ( ( -LRB- cord-005453-4057qib7 5521 8 BM BM NNP cord-005453-4057qib7 5521 9 ) ) -RRB- cord-005453-4057qib7 5521 10 graft graft NN cord-005453-4057qib7 5521 11 with with IN cord-005453-4057qib7 5521 12 single single JJ cord-005453-4057qib7 5521 13 - - HYPH cord-005453-4057qib7 5521 14 agent agent NN cord-005453-4057qib7 5521 15 PTCy PTCy NNS cord-005453-4057qib7 5521 16 and and CC cord-005453-4057qib7 5521 17 53 53 CD cord-005453-4057qib7 5521 18 received receive VBD cord-005453-4057qib7 5521 19 unrelated unrelated JJ cord-005453-4057qib7 5521 20 peripheral peripheral JJ cord-005453-4057qib7 5521 21 blood blood NN cord-005453-4057qib7 5521 22 stem stem NN cord-005453-4057qib7 5521 23 cell cell NN cord-005453-4057qib7 5521 24 graft graft NN cord-005453-4057qib7 5521 25 ( ( -LRB- cord-005453-4057qib7 5521 26 PBSC PBSC NNP cord-005453-4057qib7 5521 27 ) ) -RRB- cord-005453-4057qib7 5521 28 with with IN cord-005453-4057qib7 5521 29 PTCy PTCy NNS cord-005453-4057qib7 5521 30 , , , cord-005453-4057qib7 5521 31 tacrolimus tacrolimus NN cord-005453-4057qib7 5521 32 and and CC cord-005453-4057qib7 5521 33 MMF mmf NN cord-005453-4057qib7 5521 34 . . . cord-005453-4057qib7 5522 1 The the DT cord-005453-4057qib7 5522 2 grafts graft NNS cord-005453-4057qib7 5522 3 were be VBD cord-005453-4057qib7 5522 4 studied study VBN cord-005453-4057qib7 5522 5 by by IN cord-005453-4057qib7 5522 6 flow flow NN cord-005453-4057qib7 5522 7 cytometry cytometry NN cord-005453-4057qib7 5522 8 ( ( -LRB- cord-005453-4057qib7 5522 9 FACS FACS NNP cord-005453-4057qib7 5522 10 Aria Aria NNP cord-005453-4057qib7 5522 11 II II NNP cord-005453-4057qib7 5522 12 , , , cord-005453-4057qib7 5522 13 antibodies antibody NNS cord-005453-4057qib7 5522 14 by by IN cord-005453-4057qib7 5522 15 Miltenyi Miltenyi NNP cord-005453-4057qib7 5522 16 biotec biotec NNP cord-005453-4057qib7 5522 17 ) ) -RRB- cord-005453-4057qib7 5522 18 . . . cord-005453-4057qib7 5523 1 The the DT cord-005453-4057qib7 5523 2 following follow VBG cord-005453-4057qib7 5523 3 populations population NNS cord-005453-4057qib7 5523 4 were be VBD cord-005453-4057qib7 5523 5 analyzed analyze VBN cord-005453-4057qib7 5523 6 : : : cord-005453-4057qib7 5523 7 CD3 CD3 NNP cord-005453-4057qib7 5523 8 , , , cord-005453-4057qib7 5523 9 CD4 CD4 NNP cord-005453-4057qib7 5523 10 , , , cord-005453-4057qib7 5523 11 CD8 CD8 NNP cord-005453-4057qib7 5523 12 , , , cord-005453-4057qib7 5523 13 CD16CD56 CD16CD56 NNP cord-005453-4057qib7 5523 14 , , , cord-005453-4057qib7 5523 15 NKT NKT NNP cord-005453-4057qib7 5523 16 , , , cord-005453-4057qib7 5523 17 iNKT inkt NN cord-005453-4057qib7 5523 18 , , , cord-005453-4057qib7 5523 19 Treg Treg NNP cord-005453-4057qib7 5523 20 , , , cord-005453-4057qib7 5523 21 double double JJ cord-005453-4057qib7 5523 22 - - HYPH cord-005453-4057qib7 5523 23 positive positive JJ cord-005453-4057qib7 5523 24 T t NN cord-005453-4057qib7 5523 25 - - HYPH cord-005453-4057qib7 5523 26 cells cell NNS cord-005453-4057qib7 5523 27 , , , cord-005453-4057qib7 5523 28 double double JJ cord-005453-4057qib7 5523 29 - - HYPH cord-005453-4057qib7 5523 30 negative negative JJ cord-005453-4057qib7 5523 31 T t NN cord-005453-4057qib7 5523 32 - - HYPH cord-005453-4057qib7 5523 33 cells cell NNS cord-005453-4057qib7 5523 34 , , , cord-005453-4057qib7 5523 35 TCRalpha tcralpha NN cord-005453-4057qib7 5523 36 / / SYM cord-005453-4057qib7 5523 37 beta beta NN cord-005453-4057qib7 5523 38 , , , cord-005453-4057qib7 5523 39 TCR TCR NNP cord-005453-4057qib7 5523 40 v11 v11 VBZ cord-005453-4057qib7 5523 41 memory memory NN cord-005453-4057qib7 5523 42 cells cell NNS cord-005453-4057qib7 5523 43 . . . cord-005453-4057qib7 5524 1 The the DT cord-005453-4057qib7 5524 2 crypreserved crypreserved JJ cord-005453-4057qib7 5524 3 plasma plasma NN cord-005453-4057qib7 5524 4 from from IN cord-005453-4057qib7 5524 5 were be VBD cord-005453-4057qib7 5524 6 analysed analyse VBN cord-005453-4057qib7 5524 7 by by IN cord-005453-4057qib7 5524 8 ELISA ELISA NNP cord-005453-4057qib7 5524 9 ( ( -LRB- cord-005453-4057qib7 5524 10 commercial commercial JJ cord-005453-4057qib7 5524 11 kits kit NNS cord-005453-4057qib7 5524 12 by by IN cord-005453-4057qib7 5524 13 eBioscience eBioscience NNP cord-005453-4057qib7 5524 14 and and CC cord-005453-4057qib7 5524 15 Critical Critical NNP cord-005453-4057qib7 5524 16 Diagnostics Diagnostics NNPS cord-005453-4057qib7 5524 17 ) ) -RRB- cord-005453-4057qib7 5524 18 for for IN cord-005453-4057qib7 5524 19 VEGF VEGF NNP cord-005453-4057qib7 5524 20 A a DT cord-005453-4057qib7 5524 21 soluble soluble JJ cord-005453-4057qib7 5524 22 TNF TNF NNP cord-005453-4057qib7 5524 23 receptor receptor NN cord-005453-4057qib7 5524 24 ( ( -LRB- cord-005453-4057qib7 5524 25 sTNFr stnfr ADD cord-005453-4057qib7 5524 26 ) ) -RRB- cord-005453-4057qib7 5524 27 , , , cord-005453-4057qib7 5524 28 IL-8 IL-8 NNP cord-005453-4057qib7 5524 29 , , , cord-005453-4057qib7 5524 30 IL-6 IL-6 NNP cord-005453-4057qib7 5524 31 , , , cord-005453-4057qib7 5524 32 soluble soluble JJ cord-005453-4057qib7 5524 33 IL-2 IL-2 NNP cord-005453-4057qib7 5524 34 receptor receptor NN cord-005453-4057qib7 5524 35 , , , cord-005453-4057qib7 5524 36 ST2 ST2 NNP cord-005453-4057qib7 5524 37 , , , cord-005453-4057qib7 5524 38 IL-17 IL-17 NNP cord-005453-4057qib7 5524 39 and and CC cord-005453-4057qib7 5524 40 sTNFr stnfr ADD cord-005453-4057qib7 5524 41 . . . cord-005453-4057qib7 5525 1 The the DT cord-005453-4057qib7 5525 2 above above RB cord-005453-4057qib7 5525 3 mentioned mention VBN cord-005453-4057qib7 5525 4 biomarkers biomarker NNS cord-005453-4057qib7 5525 5 were be VBD cord-005453-4057qib7 5525 6 tested test VBN cord-005453-4057qib7 5525 7 in in IN cord-005453-4057qib7 5525 8 logistic logistic JJ cord-005453-4057qib7 5525 9 regression regression NN cord-005453-4057qib7 5525 10 with with IN cord-005453-4057qib7 5525 11 ROC ROC NNP cord-005453-4057qib7 5525 12 analysis analysis NN cord-005453-4057qib7 5525 13 , , , cord-005453-4057qib7 5525 14 assays assay NNS cord-005453-4057qib7 5525 15 with with IN cord-005453-4057qib7 5525 16 AUC>0.600 AUC>0.600 NNP cord-005453-4057qib7 5525 17 were be VBD cord-005453-4057qib7 5525 18 selected select VBN cord-005453-4057qib7 5525 19 for for IN cord-005453-4057qib7 5525 20 analysis analysis NN cord-005453-4057qib7 5525 21 in in IN cord-005453-4057qib7 5525 22 Fyne Fyne NNP cord-005453-4057qib7 5525 23 - - HYPH cord-005453-4057qib7 5525 24 Gray gray JJ cord-005453-4057qib7 5525 25 regression regression NN cord-005453-4057qib7 5525 26 with with IN cord-005453-4057qib7 5525 27 competing compete VBG cord-005453-4057qib7 5525 28 risks risk NNS cord-005453-4057qib7 5525 29 . . . cord-005453-4057qib7 5526 1 Cut cut VB cord-005453-4057qib7 5526 2 off off RP cord-005453-4057qib7 5526 3 levels level NNS cord-005453-4057qib7 5526 4 were be VBD cord-005453-4057qib7 5526 5 determined determine VBN cord-005453-4057qib7 5526 6 for for IN cord-005453-4057qib7 5526 7 significant significant JJ cord-005453-4057qib7 5526 8 parameters parameter NNS cord-005453-4057qib7 5526 9 . . . cord-005453-4057qib7 5527 1 Results result NNS cord-005453-4057qib7 5527 2 : : : cord-005453-4057qib7 5528 1 Median median JJ cord-005453-4057qib7 5528 2 follow follow NN cord-005453-4057qib7 5528 3 - - HYPH cord-005453-4057qib7 5528 4 up up NN cord-005453-4057qib7 5528 5 was be VBD cord-005453-4057qib7 5528 6 19 19 CD cord-005453-4057qib7 5528 7 months month NNS cord-005453-4057qib7 5529 1 ( ( -LRB- cord-005453-4057qib7 5529 2 range range NNP cord-005453-4057qib7 5529 3 12 12 CD cord-005453-4057qib7 5529 4 - - SYM cord-005453-4057qib7 5529 5 30 30 CD cord-005453-4057qib7 5529 6 ) ) -RRB- cord-005453-4057qib7 5529 7 . . . cord-005453-4057qib7 5530 1 In in IN cord-005453-4057qib7 5530 2 the the DT cord-005453-4057qib7 5530 3 whole whole JJ cord-005453-4057qib7 5530 4 group group NN cord-005453-4057qib7 5530 5 overall overall JJ cord-005453-4057qib7 5530 6 survival survival NN cord-005453-4057qib7 5530 7 ( ( -LRB- cord-005453-4057qib7 5530 8 OS OS NNP cord-005453-4057qib7 5530 9 ) ) -RRB- cord-005453-4057qib7 5530 10 was be VBD cord-005453-4057qib7 5530 11 77 77 CD cord-005453-4057qib7 5530 12 % % NN cord-005453-4057qib7 5530 13 , , , cord-005453-4057qib7 5530 14 eventfree eventfree NNP cord-005453-4057qib7 5530 15 survival survival NNP cord-005453-4057qib7 5530 16 ( ( -LRB- cord-005453-4057qib7 5530 17 EFS EFS NNP cord-005453-4057qib7 5530 18 ) ) -RRB- cord-005453-4057qib7 5530 19 73 73 CD cord-005453-4057qib7 5530 20 % % NN cord-005453-4057qib7 5530 21 , , , cord-005453-4057qib7 5530 22 grade grade NN cord-005453-4057qib7 5530 23 II II NNP cord-005453-4057qib7 5530 24 - - HYPH cord-005453-4057qib7 5530 25 IV IV NNP cord-005453-4057qib7 5530 26 acute acute JJ cord-005453-4057qib7 5530 27 GVHD GVHD NNP cord-005453-4057qib7 5530 28 13 13 CD cord-005453-4057qib7 5530 29 % % NN cord-005453-4057qib7 5530 30 , , , cord-005453-4057qib7 5530 31 moderate moderate JJ cord-005453-4057qib7 5530 32 and and CC cord-005453-4057qib7 5530 33 severe severe JJ cord-005453-4057qib7 5530 34 ( ( -LRB- cord-005453-4057qib7 5530 35 m&s m&s NN cord-005453-4057qib7 5530 36 ) ) -RRB- cord-005453-4057qib7 5530 37 chronic chronic JJ cord-005453-4057qib7 5530 38 GVHD GVHD NNP cord-005453-4057qib7 5530 39 20 20 CD cord-005453-4057qib7 5530 40 % % NN cord-005453-4057qib7 5530 41 , , , cord-005453-4057qib7 5530 42 NRM NRM NNP cord-005453-4057qib7 5530 43 6 6 CD cord-005453-4057qib7 5530 44 % % NN cord-005453-4057qib7 5530 45 , , , cord-005453-4057qib7 5530 46 mortality mortality NN cord-005453-4057qib7 5530 47 in in IN cord-005453-4057qib7 5530 48 patients patient NNS cord-005453-4057qib7 5530 49 with with IN cord-005453-4057qib7 5530 50 GVHD GVHD NNP cord-005453-4057qib7 5530 51 0 0 CD cord-005453-4057qib7 5530 52 % % NN cord-005453-4057qib7 5530 53 , , , cord-005453-4057qib7 5530 54 RI RI NNP cord-005453-4057qib7 5530 55 20 20 CD cord-005453-4057qib7 5530 56 % % NN cord-005453-4057qib7 5530 57 . . . cord-005453-4057qib7 5531 1 There there EX cord-005453-4057qib7 5531 2 was be VBD cord-005453-4057qib7 5531 3 no no DT cord-005453-4057qib7 5531 4 difference difference NN cord-005453-4057qib7 5531 5 between between IN cord-005453-4057qib7 5531 6 BM BM NNP cord-005453-4057qib7 5531 7 / / SYM cord-005453-4057qib7 5531 8 related relate VBN cord-005453-4057qib7 5531 9 and and CC cord-005453-4057qib7 5531 10 PBSC PBSC NNP cord-005453-4057qib7 5531 11 / / SYM cord-005453-4057qib7 5531 12 unrelated unrelated JJ cord-005453-4057qib7 5531 13 grafts graft NNS cord-005453-4057qib7 5531 14 in in IN cord-005453-4057qib7 5531 15 the the DT cord-005453-4057qib7 5531 16 incidence incidence NN cord-005453-4057qib7 5531 17 of of IN cord-005453-4057qib7 5531 18 GVHD GVHD NNP cord-005453-4057qib7 5531 19 , , , cord-005453-4057qib7 5531 20 NRM NRM NNP cord-005453-4057qib7 5531 21 and and CC cord-005453-4057qib7 5531 22 RI RI NNP cord-005453-4057qib7 5531 23 ( ( -LRB- cord-005453-4057qib7 5531 24 p>0.11 p>0.11 NNP cord-005453-4057qib7 5531 25 ) ) -RRB- cord-005453-4057qib7 5531 26 . . . cord-005453-4057qib7 5532 1 The the DT cord-005453-4057qib7 5532 2 only only JJ cord-005453-4057qib7 5532 3 significant significant JJ cord-005453-4057qib7 5532 4 predictor predictor NN cord-005453-4057qib7 5532 5 of of IN cord-005453-4057qib7 5532 6 acute acute JJ cord-005453-4057qib7 5532 7 GVHD GVHD NNP cord-005453-4057qib7 5532 8 were be VBD cord-005453-4057qib7 5532 9 low low JJ cord-005453-4057qib7 5532 10 levels level NNS cord-005453-4057qib7 5532 11 of of IN cord-005453-4057qib7 5532 12 IL-8 IL-8 NNP cord-005453-4057qib7 5532 13 level level NN cord-005453-4057qib7 5532 14 on on IN cord-005453-4057qib7 5532 15 day+7 day+7 NNS cord-005453-4057qib7 5532 16 ( ( -LRB- cord-005453-4057qib7 5532 17 p= p= NNP cord-005453-4057qib7 5532 18 0.0490 0.0490 CD cord-005453-4057qib7 5532 19 , , , cord-005453-4057qib7 5532 20 0 0 CD cord-005453-4057qib7 5532 21 % % NN cord-005453-4057qib7 5532 22 vs vs IN cord-005453-4057qib7 5532 23 15 15 CD cord-005453-4057qib7 5532 24 % % NN cord-005453-4057qib7 5532 25 with with IN cord-005453-4057qib7 5532 26 the the DT cord-005453-4057qib7 5532 27 cut cut NN cord-005453-4057qib7 5532 28 off off RP cord-005453-4057qib7 5532 29 40 40 CD cord-005453-4057qib7 5532 30 pg pg NNP cord-005453-4057qib7 5532 31 / / SYM cord-005453-4057qib7 5532 32 ml ml NN cord-005453-4057qib7 5532 33 ) ) -RRB- cord-005453-4057qib7 5532 34 . . . cord-005453-4057qib7 5533 1 M&s M&s NNP cord-005453-4057qib7 5533 2 chronic chronic NNP cord-005453-4057qib7 5533 3 GVHD GVHD NNP cord-005453-4057qib7 5533 4 was be VBD cord-005453-4057qib7 5533 5 predicted predict VBN cord-005453-4057qib7 5533 6 only only RB cord-005453-4057qib7 5533 7 by by IN cord-005453-4057qib7 5533 8 the the DT cord-005453-4057qib7 5533 9 high high JJ cord-005453-4057qib7 5533 10 percentage percentage NN cord-005453-4057qib7 5533 11 of of IN cord-005453-4057qib7 5533 12 iNKT inkt JJ cord-005453-4057qib7 5533 13 cells cell NNS cord-005453-4057qib7 5533 14 in in IN cord-005453-4057qib7 5533 15 the the DT cord-005453-4057qib7 5533 16 graft graft NN cord-005453-4057qib7 5533 17 ( ( -LRB- cord-005453-4057qib7 5533 18 p=0.0003 p=0.0003 NNP cord-005453-4057qib7 5533 19 , , , cord-005453-4057qib7 5533 20 31 31 CD cord-005453-4057qib7 5533 21 % % NN cord-005453-4057qib7 5533 22 vs vs IN cord-005453-4057qib7 5533 23 12 12 CD cord-005453-4057qib7 5533 24 % % NN cord-005453-4057qib7 5533 25 with with IN cord-005453-4057qib7 5533 26 the the DT cord-005453-4057qib7 5533 27 cut cut NN cord-005453-4057qib7 5533 28 off off RP cord-005453-4057qib7 5533 29 0.03 0.03 CD cord-005453-4057qib7 5533 30 % % NN cord-005453-4057qib7 5533 31 ) ) -RRB- cord-005453-4057qib7 5533 32 . . . cord-005453-4057qib7 5534 1 There there EX cord-005453-4057qib7 5534 2 was be VBD cord-005453-4057qib7 5534 3 a a DT cord-005453-4057qib7 5534 4 correlation correlation NN cord-005453-4057qib7 5534 5 between between IN cord-005453-4057qib7 5534 6 IL-8 IL-8 NNP cord-005453-4057qib7 5534 7 levels level NNS cord-005453-4057qib7 5534 8 and and CC cord-005453-4057qib7 5534 9 number number NN cord-005453-4057qib7 5534 10 of of IN cord-005453-4057qib7 5534 11 NK NK NNP cord-005453-4057qib7 5534 12 cells cell NNS cord-005453-4057qib7 5534 13 in in IN cord-005453-4057qib7 5534 14 the the DT cord-005453-4057qib7 5534 15 graft graft NN cord-005453-4057qib7 5534 16 ( ( -LRB- cord-005453-4057qib7 5534 17 p=0.02 p=0.02 NN cord-005453-4057qib7 5534 18 ) ) -RRB- cord-005453-4057qib7 5534 19 . . . cord-005453-4057qib7 5535 1 NRM NRM NNP cord-005453-4057qib7 5535 2 was be VBD cord-005453-4057qib7 5535 3 related relate VBN cord-005453-4057qib7 5535 4 to to IN cord-005453-4057qib7 5535 5 infectious infectious JJ cord-005453-4057qib7 5535 6 complications complication NNS cord-005453-4057qib7 5535 7 , , , cord-005453-4057qib7 5535 8 nonetheless nonetheless RB cord-005453-4057qib7 5535 9 high high JJ cord-005453-4057qib7 5535 10 levels level NNS cord-005453-4057qib7 5535 11 of of IN cord-005453-4057qib7 5535 12 VEGF VEGF NNP cord-005453-4057qib7 5535 13 A A NNP cord-005453-4057qib7 5535 14 on on IN cord-005453-4057qib7 5535 15 day day NN cord-005453-4057qib7 5535 16 0 0 NFP cord-005453-4057qib7 5535 17 ( ( -LRB- cord-005453-4057qib7 5535 18 p= p= NNP cord-005453-4057qib7 5535 19 0.0458 0.0458 CD cord-005453-4057qib7 5535 20 , , , cord-005453-4057qib7 5535 21 16 16 CD cord-005453-4057qib7 5535 22 % % NN cord-005453-4057qib7 5535 23 vs vs IN cord-005453-4057qib7 5535 24 0 0 CD cord-005453-4057qib7 5535 25 % % NN cord-005453-4057qib7 5535 26 with with IN cord-005453-4057qib7 5535 27 the the DT cord-005453-4057qib7 5535 28 cut cut NN cord-005453-4057qib7 5535 29 off off RP cord-005453-4057qib7 5535 30 100 100 CD cord-005453-4057qib7 5535 31 ng ng NN cord-005453-4057qib7 5535 32 / / SYM cord-005453-4057qib7 5535 33 ml ml NNP cord-005453-4057qib7 5535 34 ) ) -RRB- cord-005453-4057qib7 5535 35 , , , cord-005453-4057qib7 5535 36 ST2 ST2 NNP cord-005453-4057qib7 5535 37 on on IN cord-005453-4057qib7 5535 38 day+30 day+30 NNP cord-005453-4057qib7 5535 39 ( ( -LRB- cord-005453-4057qib7 5535 40 p= p= NNP cord-005453-4057qib7 5535 41 0.0041 0.0041 CD cord-005453-4057qib7 5535 42 , , , cord-005453-4057qib7 5535 43 11 11 CD cord-005453-4057qib7 5535 44 % % NN cord-005453-4057qib7 5535 45 vs vs IN cord-005453-4057qib7 5535 46 0 0 CD cord-005453-4057qib7 5535 47 % % NN cord-005453-4057qib7 5535 48 % % NN cord-005453-4057qib7 5535 49 with with IN cord-005453-4057qib7 5535 50 the the DT cord-005453-4057qib7 5535 51 cut cut NN cord-005453-4057qib7 5535 52 off off RP cord-005453-4057qib7 5535 53 40 40 CD cord-005453-4057qib7 5535 54 ng ng NNP cord-005453-4057qib7 5535 55 / / SYM cord-005453-4057qib7 5535 56 ml ml NN cord-005453-4057qib7 5535 57 ) ) -RRB- cord-005453-4057qib7 5535 58 and and CC cord-005453-4057qib7 5535 59 low low JJ cord-005453-4057qib7 5535 60 percentage percentage NN cord-005453-4057qib7 5535 61 of of IN cord-005453-4057qib7 5535 62 CD16+CD56-cells cd16+cd56-cell NNS cord-005453-4057qib7 5535 63 in in IN cord-005453-4057qib7 5535 64 the the DT cord-005453-4057qib7 5535 65 graft graft NN cord-005453-4057qib7 5535 66 ( ( -LRB- cord-005453-4057qib7 5535 67 p=0.0215 p=0.0215 NN cord-005453-4057qib7 5535 68 , , , cord-005453-4057qib7 5535 69 22 22 CD cord-005453-4057qib7 5535 70 % % NN cord-005453-4057qib7 5535 71 vs vs IN cord-005453-4057qib7 5535 72 2 2 CD cord-005453-4057qib7 5535 73 % % NN cord-005453-4057qib7 5535 74 with with IN cord-005453-4057qib7 5535 75 the the DT cord-005453-4057qib7 5535 76 cut cut NN cord-005453-4057qib7 5535 77 off off RP cord-005453-4057qib7 5535 78 1.3 1.3 CD cord-005453-4057qib7 5535 79 % % NN cord-005453-4057qib7 5535 80 ) ) -RRB- cord-005453-4057qib7 5535 81 . . . cord-005453-4057qib7 5536 1 The the DT cord-005453-4057qib7 5536 2 identified identify VBN cord-005453-4057qib7 5536 3 biomarkers biomarker NNS cord-005453-4057qib7 5536 4 of of IN cord-005453-4057qib7 5536 5 NRM NRM NNP cord-005453-4057qib7 5536 6 had have VBD cord-005453-4057qib7 5536 7 no no DT cord-005453-4057qib7 5536 8 association association NN cord-005453-4057qib7 5536 9 with with IN cord-005453-4057qib7 5536 10 the the DT cord-005453-4057qib7 5536 11 pre pre JJ cord-005453-4057qib7 5536 12 - - JJ cord-005453-4057qib7 5536 13 transplant transplant JJ cord-005453-4057qib7 5536 14 CRP crp NN cord-005453-4057qib7 5536 15 and and CC cord-005453-4057qib7 5536 16 ferritin ferritin NN cord-005453-4057qib7 5536 17 levels level NNS cord-005453-4057qib7 5536 18 ( ( -LRB- cord-005453-4057qib7 5536 19 p>0.4 p>0.4 NNS cord-005453-4057qib7 5536 20 ) ) -RRB- cord-005453-4057qib7 5536 21 . . . cord-005453-4057qib7 5537 1 The the DT cord-005453-4057qib7 5537 2 only only JJ cord-005453-4057qib7 5537 3 significant significant JJ cord-005453-4057qib7 5537 4 parameter parameter NN cord-005453-4057qib7 5537 5 for for IN cord-005453-4057qib7 5537 6 RI RI NNP cord-005453-4057qib7 5537 7 was be VBD cord-005453-4057qib7 5537 8 the the DT cord-005453-4057qib7 5537 9 level level NN cord-005453-4057qib7 5537 10 of of IN cord-005453-4057qib7 5537 11 CD34 CD34 NNP cord-005453-4057qib7 5537 12 cells cell NNS cord-005453-4057qib7 5537 13 in in IN cord-005453-4057qib7 5537 14 the the DT cord-005453-4057qib7 5537 15 graft graft NN cord-005453-4057qib7 5537 16 ( ( -LRB- cord-005453-4057qib7 5537 17 p=0.0434 p=0.0434 NNS cord-005453-4057qib7 5537 18 ) ) -RRB- cord-005453-4057qib7 5537 19 . . . cord-005453-4057qib7 5538 1 None none NN cord-005453-4057qib7 5538 2 of of IN cord-005453-4057qib7 5538 3 the the DT cord-005453-4057qib7 5538 4 identified identify VBN cord-005453-4057qib7 5538 5 biomarkers biomarker NNS cord-005453-4057qib7 5538 6 significantly significantly RB cord-005453-4057qib7 5538 7 predicted predict VBD cord-005453-4057qib7 5538 8 overall overall JJ cord-005453-4057qib7 5538 9 survival survival NN cord-005453-4057qib7 5538 10 ( ( -LRB- cord-005453-4057qib7 5538 11 p>0.09 p>0.09 NN cord-005453-4057qib7 5538 12 ) ) -RRB- cord-005453-4057qib7 5538 13 . . . cord-005453-4057qib7 5539 1 Conclusions conclusion NNS cord-005453-4057qib7 5539 2 : : : cord-005453-4057qib7 5540 1 In in IN cord-005453-4057qib7 5540 2 the the DT cord-005453-4057qib7 5540 3 related related JJ cord-005453-4057qib7 5540 4 and and CC cord-005453-4057qib7 5540 5 unrelated unrelated JJ cord-005453-4057qib7 5540 6 grafts graft NNS cord-005453-4057qib7 5540 7 with with IN cord-005453-4057qib7 5540 8 PTCy PTCy NNS cord-005453-4057qib7 5540 9 the the DT cord-005453-4057qib7 5540 10 study study NN cord-005453-4057qib7 5540 11 of of IN cord-005453-4057qib7 5540 12 biomarkers biomarker NNS cord-005453-4057qib7 5540 13 has have VBZ cord-005453-4057qib7 5540 14 low low JJ cord-005453-4057qib7 5540 15 clinical clinical JJ cord-005453-4057qib7 5540 16 utility utility NN cord-005453-4057qib7 5540 17 due due IN cord-005453-4057qib7 5540 18 to to IN cord-005453-4057qib7 5540 19 very very RB cord-005453-4057qib7 5540 20 low low JJ cord-005453-4057qib7 5540 21 GVHD gvhd NN cord-005453-4057qib7 5540 22 - - HYPH cord-005453-4057qib7 5540 23 related relate VBN cord-005453-4057qib7 5540 24 mortality mortality NN cord-005453-4057qib7 5540 25 . . . cord-005453-4057qib7 5541 1 However however RB cord-005453-4057qib7 5541 2 ST2 ST2 NNP cord-005453-4057qib7 5541 3 and and CC cord-005453-4057qib7 5541 4 VEGF VEGF NNP cord-005453-4057qib7 5541 5 A A NNP cord-005453-4057qib7 5541 6 can can MD cord-005453-4057qib7 5541 7 predict predict VB cord-005453-4057qib7 5541 8 infection infection NN cord-005453-4057qib7 5541 9 - - HYPH cord-005453-4057qib7 5541 10 related relate VBN cord-005453-4057qib7 5541 11 mortality mortality NN cord-005453-4057qib7 5541 12 . . . cord-005453-4057qib7 5542 1 Also also RB cord-005453-4057qib7 5542 2 the the DT cord-005453-4057qib7 5542 3 study study NN cord-005453-4057qib7 5542 4 verified verify VBD cord-005453-4057qib7 5542 5 previous previous JJ cord-005453-4057qib7 5542 6 observations observation NNS cord-005453-4057qib7 5542 7 that that IN cord-005453-4057qib7 5542 8 high high JJ cord-005453-4057qib7 5542 9 level level NN cord-005453-4057qib7 5542 10 of of IN cord-005453-4057qib7 5542 11 IL-8 IL-8 NNP cord-005453-4057qib7 5542 12 is be VBZ cord-005453-4057qib7 5542 13 associated associate VBN cord-005453-4057qib7 5542 14 with with IN cord-005453-4057qib7 5542 15 reduced reduce VBN cord-005453-4057qib7 5542 16 GVHD GVHD NNP cord-005453-4057qib7 5542 17 incidence incidence NN cord-005453-4057qib7 5542 18 after after IN cord-005453-4057qib7 5542 19 PTCy PTCy NNS cord-005453-4057qib7 5542 20 1 1 CD cord-005453-4057qib7 5542 21 and and CC cord-005453-4057qib7 5542 22 identified identify VBD cord-005453-4057qib7 5542 23 the the DT cord-005453-4057qib7 5542 24 importance importance NN cord-005453-4057qib7 5542 25 of of IN cord-005453-4057qib7 5542 26 NK NK NNP cord-005453-4057qib7 5542 27 and and CC cord-005453-4057qib7 5542 28 iNKT inkt JJ cord-005453-4057qib7 5542 29 cells cell NNS cord-005453-4057qib7 5542 30 in in IN cord-005453-4057qib7 5542 31 the the DT cord-005453-4057qib7 5542 32 induction induction NN cord-005453-4057qib7 5542 33 of of IN cord-005453-4057qib7 5542 34 tolerance tolerance NN cord-005453-4057qib7 5542 35 with with IN cord-005453-4057qib7 5542 36 PTCy PTCy NNS cord-005453-4057qib7 5542 37 . . . cord-005453-4057qib7 5543 1 References reference NNS cord-005453-4057qib7 5543 2 Background Background NNP cord-005453-4057qib7 5543 3 : : : cord-005453-4057qib7 5543 4 Hematopoietic hematopoietic JJ cord-005453-4057qib7 5543 5 cell cell NN cord-005453-4057qib7 5543 6 transplantation transplantation NN cord-005453-4057qib7 5543 7 ( ( -LRB- cord-005453-4057qib7 5543 8 HCT HCT NNP cord-005453-4057qib7 5543 9 ) ) -RRB- cord-005453-4057qib7 5543 10 is be VBZ cord-005453-4057qib7 5543 11 the the DT cord-005453-4057qib7 5543 12 only only JJ cord-005453-4057qib7 5543 13 curative curative JJ cord-005453-4057qib7 5543 14 approach approach NN cord-005453-4057qib7 5543 15 for for IN cord-005453-4057qib7 5543 16 many many JJ cord-005453-4057qib7 5543 17 hematological hematological JJ cord-005453-4057qib7 5543 18 malignancies malignancy NNS cord-005453-4057qib7 5543 19 but but CC cord-005453-4057qib7 5543 20 life life NN cord-005453-4057qib7 5543 21 - - HYPH cord-005453-4057qib7 5543 22 threatening threaten VBG cord-005453-4057qib7 5543 23 toxicities toxicity NNS cord-005453-4057qib7 5543 24 , , , cord-005453-4057qib7 5543 25 such such JJ cord-005453-4057qib7 5543 26 as as IN cord-005453-4057qib7 5543 27 graft graft NN cord-005453-4057qib7 5543 28 - - HYPH cord-005453-4057qib7 5543 29 versushost versushost NN cord-005453-4057qib7 5543 30 disease disease NN cord-005453-4057qib7 5543 31 ( ( -LRB- cord-005453-4057qib7 5543 32 GVHD GVHD NNP cord-005453-4057qib7 5543 33 ) ) -RRB- cord-005453-4057qib7 5543 34 and and CC cord-005453-4057qib7 5543 35 infections infection NNS cord-005453-4057qib7 5543 36 , , , cord-005453-4057qib7 5543 37 still still RB cord-005453-4057qib7 5543 38 limit limit VB cord-005453-4057qib7 5543 39 its -PRON- PRP$ cord-005453-4057qib7 5543 40 fullpotential fullpotential JJ cord-005453-4057qib7 5543 41 impact impact NN cord-005453-4057qib7 5543 42 on on IN cord-005453-4057qib7 5543 43 the the DT cord-005453-4057qib7 5543 44 disease disease NN cord-005453-4057qib7 5543 45 . . . cord-005453-4057qib7 5544 1 Strategies strategy NNS cord-005453-4057qib7 5544 2 for for IN cord-005453-4057qib7 5544 3 keeping keep VBG cord-005453-4057qib7 5544 4 alloHSCT allohsct RB cord-005453-4057qib7 5544 5 more more RBR cord-005453-4057qib7 5544 6 effective effective JJ cord-005453-4057qib7 5544 7 and and CC cord-005453-4057qib7 5544 8 safe safe JJ cord-005453-4057qib7 5544 9 are be VBP cord-005453-4057qib7 5544 10 needed need VBN cord-005453-4057qib7 5544 11 in in IN cord-005453-4057qib7 5544 12 order order NN cord-005453-4057qib7 5544 13 to to TO cord-005453-4057qib7 5544 14 reduce reduce VB cord-005453-4057qib7 5544 15 morbidity morbidity NN cord-005453-4057qib7 5544 16 while while IN cord-005453-4057qib7 5544 17 improving improve VBG cord-005453-4057qib7 5544 18 its -PRON- PRP$ cord-005453-4057qib7 5544 19 immunological immunological JJ cord-005453-4057qib7 5544 20 effect effect NN cord-005453-4057qib7 5544 21 to to TO cord-005453-4057qib7 5544 22 control control VB cord-005453-4057qib7 5544 23 disease disease NN cord-005453-4057qib7 5544 24 relapse relapse VB cord-005453-4057qib7 5544 25 . . . cord-005453-4057qib7 5545 1 Post post JJ cord-005453-4057qib7 5545 2 - - NN cord-005453-4057qib7 5545 3 transplant transplant NN cord-005453-4057qib7 5545 4 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 5545 5 ( ( -LRB- cord-005453-4057qib7 5545 6 ptCy ptcy RB cord-005453-4057qib7 5545 7 ) ) -RRB- cord-005453-4057qib7 5545 8 has have VBZ cord-005453-4057qib7 5545 9 been be VBN cord-005453-4057qib7 5545 10 demonstrated demonstrate VBN cord-005453-4057qib7 5545 11 to to TO cord-005453-4057qib7 5545 12 improve improve VB cord-005453-4057qib7 5545 13 acute acute JJ cord-005453-4057qib7 5545 14 GVHD GVHD NNP cord-005453-4057qib7 5545 15 ( ( -LRB- cord-005453-4057qib7 5545 16 aGVHD aGVHD NNP cord-005453-4057qib7 5545 17 ) ) -RRB- cord-005453-4057qib7 5545 18 and and CC cord-005453-4057qib7 5545 19 chronic chronic JJ cord-005453-4057qib7 5545 20 GVHD GVHD NNP cord-005453-4057qib7 5545 21 ( ( -LRB- cord-005453-4057qib7 5545 22 cGVHD cGVHD NNP cord-005453-4057qib7 5545 23 ) ) -RRB- cord-005453-4057qib7 5545 24 control control NN cord-005453-4057qib7 5545 25 in in IN cord-005453-4057qib7 5545 26 allogeneic allogeneic NN cord-005453-4057qib7 5545 27 bone bone NN cord-005453-4057qib7 5545 28 - - HYPH cord-005453-4057qib7 5545 29 marrow marrow NN cord-005453-4057qib7 5545 30 HCT hct NN cord-005453-4057qib7 5545 31 from from IN cord-005453-4057qib7 5545 32 identical identical JJ cord-005453-4057qib7 5545 33 and and CC cord-005453-4057qib7 5545 34 haploidentical haploidentical JJ cord-005453-4057qib7 5545 35 donor donor NN cord-005453-4057qib7 5545 36 . . . cord-005453-4057qib7 5546 1 The the DT cord-005453-4057qib7 5546 2 use use NN cord-005453-4057qib7 5546 3 of of IN cord-005453-4057qib7 5546 4 ptCy ptcy RB cord-005453-4057qib7 5546 5 , , , cord-005453-4057qib7 5546 6 after after IN cord-005453-4057qib7 5546 7 peripheral peripheral JJ cord-005453-4057qib7 5546 8 blood blood NN cord-005453-4057qib7 5546 9 stem stem NN cord-005453-4057qib7 5546 10 cell cell NN cord-005453-4057qib7 5546 11 transplantation transplantation NN cord-005453-4057qib7 5546 12 ( ( -LRB- cord-005453-4057qib7 5546 13 alloPBSCT alloPBSCT NNP cord-005453-4057qib7 5546 14 ) ) -RRB- cord-005453-4057qib7 5546 15 from from IN cord-005453-4057qib7 5546 16 HLA HLA NNP cord-005453-4057qib7 5546 17 - - HYPH cord-005453-4057qib7 5546 18 matched match VBN cord-005453-4057qib7 5546 19 unrelated unrelated JJ cord-005453-4057qib7 5546 20 / / SYM cord-005453-4057qib7 5546 21 related related JJ cord-005453-4057qib7 5546 22 donors donor NNS cord-005453-4057qib7 5546 23 , , , cord-005453-4057qib7 5546 24 has have VBZ cord-005453-4057qib7 5546 25 been be VBN cord-005453-4057qib7 5546 26 investigated investigate VBN cord-005453-4057qib7 5546 27 by by IN cord-005453-4057qib7 5546 28 our -PRON- PRP$ cord-005453-4057qib7 5546 29 group group NN cord-005453-4057qib7 5546 30 in in IN cord-005453-4057qib7 5546 31 a a DT cord-005453-4057qib7 5546 32 clinical clinical JJ cord-005453-4057qib7 5546 33 trial trial NN cord-005453-4057qib7 5546 34 ( ( -LRB- cord-005453-4057qib7 5546 35 NCT NCT NNP cord-005453-4057qib7 5546 36 02300571 02300571 CD cord-005453-4057qib7 5546 37 ) ) -RRB- cord-005453-4057qib7 5546 38 and and CC cord-005453-4057qib7 5546 39 preliminary preliminary JJ cord-005453-4057qib7 5546 40 results result NNS cord-005453-4057qib7 5546 41 were be VBD cord-005453-4057qib7 5546 42 published publish VBN cord-005453-4057qib7 5546 43 last last JJ cord-005453-4057qib7 5546 44 year year NN cord-005453-4057qib7 5546 45 . . . cord-005453-4057qib7 5547 1 Here here RB cord-005453-4057qib7 5547 2 we -PRON- PRP cord-005453-4057qib7 5547 3 report report VBP cord-005453-4057qib7 5547 4 updated update VBD cord-005453-4057qib7 5547 5 efficacy efficacy NN cord-005453-4057qib7 5547 6 and and CC cord-005453-4057qib7 5547 7 safety safety NN cord-005453-4057qib7 5547 8 data datum NNS cord-005453-4057qib7 5547 9 about about IN cord-005453-4057qib7 5547 10 the the DT cord-005453-4057qib7 5547 11 expanded expand VBN cord-005453-4057qib7 5547 12 cohort cohort NN cord-005453-4057qib7 5547 13 of of IN cord-005453-4057qib7 5547 14 patients patient NNS cord-005453-4057qib7 5547 15 treated treat VBN cord-005453-4057qib7 5547 16 with with IN cord-005453-4057qib7 5547 17 ptCy ptcy RB cord-005453-4057qib7 5547 18 followed follow VBN cord-005453-4057qib7 5547 19 by by IN cord-005453-4057qib7 5547 20 tacrolimus tacrolimus NNP cord-005453-4057qib7 5547 21 and and CC cord-005453-4057qib7 5547 22 mycophenolate mycophenolate NNP cord-005453-4057qib7 5547 23 mofetil mofetil NNP cord-005453-4057qib7 5548 1 ( ( -LRB- cord-005453-4057qib7 5548 2 T T NNP cord-005453-4057qib7 5548 3 / / SYM cord-005453-4057qib7 5548 4 MMF MMF NNP cord-005453-4057qib7 5548 5 ) ) -RRB- cord-005453-4057qib7 5548 6 . . . cord-005453-4057qib7 5549 1 Methods method NNS cord-005453-4057qib7 5549 2 : : : cord-005453-4057qib7 5550 1 We -PRON- PRP cord-005453-4057qib7 5550 2 analysed analyse VBD cord-005453-4057qib7 5550 3 data datum NNS cord-005453-4057qib7 5550 4 about about IN cord-005453-4057qib7 5550 5 71 71 CD cord-005453-4057qib7 5550 6 consecutive consecutive JJ cord-005453-4057qib7 5550 7 patients patient NNS cord-005453-4057qib7 5550 8 with with IN cord-005453-4057qib7 5550 9 high high JJ cord-005453-4057qib7 5550 10 - - HYPH cord-005453-4057qib7 5550 11 risk risk NN cord-005453-4057qib7 5550 12 hematologic hematologic JJ cord-005453-4057qib7 5550 13 malignancies malignancy NNS cord-005453-4057qib7 5550 14 received receive VBD cord-005453-4057qib7 5550 15 alloPBSCT alloPBSCT NNP cord-005453-4057qib7 5550 16 from from IN cord-005453-4057qib7 5550 17 HLA HLA NNP cord-005453-4057qib7 5550 18 - - HYPH cord-005453-4057qib7 5550 19 matched match VBN cord-005453-4057qib7 5550 20 unrelated unrelated JJ cord-005453-4057qib7 5550 21 / / SYM cord-005453-4057qib7 5550 22 related relate VBN cord-005453-4057qib7 5550 23 donors donor NNS cord-005453-4057qib7 5550 24 between between IN cord-005453-4057qib7 5550 25 March March NNP cord-005453-4057qib7 5550 26 2011 2011 CD cord-005453-4057qib7 5550 27 and and CC cord-005453-4057qib7 5550 28 August August NNP cord-005453-4057qib7 5550 29 2018 2018 CD cord-005453-4057qib7 5550 30 . . . cord-005453-4057qib7 5551 1 GVHD GVHD NNP cord-005453-4057qib7 5551 2 prophylaxis prophylaxis NN cord-005453-4057qib7 5551 3 was be VBD cord-005453-4057qib7 5551 4 ptCy ptcy RB cord-005453-4057qib7 5551 5 50 50 CD cord-005453-4057qib7 5551 6 mg mg NNP cord-005453-4057qib7 5551 7 / / SYM cord-005453-4057qib7 5551 8 kg kg NNP cord-005453-4057qib7 5551 9 ( ( -LRB- cord-005453-4057qib7 5551 10 days day NNS cord-005453-4057qib7 5551 11 +3 +3 NNP cord-005453-4057qib7 5551 12 +4 +4 NN cord-005453-4057qib7 5551 13 ) ) -RRB- cord-005453-4057qib7 5551 14 , , , cord-005453-4057qib7 5551 15 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 5551 16 from from IN cord-005453-4057qib7 5551 17 day day NN cord-005453-4057qib7 5551 18 +5 +5 NN cord-005453-4057qib7 5551 19 and and CC cord-005453-4057qib7 5551 20 MMF mmf NN cord-005453-4057qib7 5551 21 from from IN cord-005453-4057qib7 5551 22 day day NN cord-005453-4057qib7 5551 23 +5 +5 NN cord-005453-4057qib7 5551 24 to to IN cord-005453-4057qib7 5551 25 day day NN cord-005453-4057qib7 5551 26 +28 +28 NNS cord-005453-4057qib7 5551 27 . . . cord-005453-4057qib7 5552 1 Primary primary JJ cord-005453-4057qib7 5552 2 objectives objective NNS cord-005453-4057qib7 5552 3 were be VBD cord-005453-4057qib7 5552 4 cumulative cumulative JJ cord-005453-4057qib7 5552 5 incidence incidence NN cord-005453-4057qib7 5552 6 of of IN cord-005453-4057qib7 5552 7 aGVHD aGVHD NNP cord-005453-4057qib7 5552 8 and and CC cord-005453-4057qib7 5552 9 cGVHD cGVHD NNP cord-005453-4057qib7 5552 10 . . . cord-005453-4057qib7 5553 1 Secondary secondary JJ cord-005453-4057qib7 5553 2 objectives objective NNS cord-005453-4057qib7 5553 3 were be VBD cord-005453-4057qib7 5553 4 event event NN cord-005453-4057qib7 5553 5 - - HYPH cord-005453-4057qib7 5553 6 free free JJ cord-005453-4057qib7 5553 7 survival survival NN cord-005453-4057qib7 5553 8 ( ( -LRB- cord-005453-4057qib7 5553 9 EFS EFS NNP cord-005453-4057qib7 5553 10 ) ) -RRB- cord-005453-4057qib7 5553 11 , , , cord-005453-4057qib7 5553 12 cGVHD cGVHD NNP cord-005453-4057qib7 5553 13 - - HYPH cord-005453-4057qib7 5553 14 EFS EFS NNP cord-005453-4057qib7 5553 15 , , , cord-005453-4057qib7 5553 16 overall overall JJ cord-005453-4057qib7 5553 17 survival survival NN cord-005453-4057qib7 5553 18 ( ( -LRB- cord-005453-4057qib7 5553 19 OS OS NNP cord-005453-4057qib7 5553 20 ) ) -RRB- cord-005453-4057qib7 5553 21 and and CC cord-005453-4057qib7 5553 22 non non JJ cord-005453-4057qib7 5553 23 - - JJ cord-005453-4057qib7 5553 24 relapse relapse JJ cord-005453-4057qib7 5553 25 mortality mortality NN cord-005453-4057qib7 5553 26 ( ( -LRB- cord-005453-4057qib7 5553 27 NRM NRM NNP cord-005453-4057qib7 5553 28 ) ) -RRB- cord-005453-4057qib7 5553 29 . . . cord-005453-4057qib7 5554 1 Results result NNS cord-005453-4057qib7 5554 2 : : : cord-005453-4057qib7 5555 1 Patients patient NNS cord-005453-4057qib7 5555 2 median median JJ cord-005453-4057qib7 5555 3 age age NN cord-005453-4057qib7 5555 4 at at IN cord-005453-4057qib7 5555 5 transplant transplant NN cord-005453-4057qib7 5555 6 was be VBD cord-005453-4057qib7 5555 7 50 50 CD cord-005453-4057qib7 5556 1 ( ( -LRB- cord-005453-4057qib7 5556 2 range range NNP cord-005453-4057qib7 5556 3 19 19 CD cord-005453-4057qib7 5556 4 - - SYM cord-005453-4057qib7 5556 5 74 74 CD cord-005453-4057qib7 5556 6 ) ) -RRB- cord-005453-4057qib7 5556 7 years year NNS cord-005453-4057qib7 5556 8 . . . cord-005453-4057qib7 5557 1 34 34 CD cord-005453-4057qib7 5557 2 ( ( -LRB- cord-005453-4057qib7 5557 3 48 48 CD cord-005453-4057qib7 5557 4 % % NN cord-005453-4057qib7 5557 5 ) ) -RRB- cord-005453-4057qib7 5557 6 patients patient NNS cord-005453-4057qib7 5557 7 were be VBD cord-005453-4057qib7 5557 8 transplanted transplant VBN cord-005453-4057qib7 5557 9 in in IN cord-005453-4057qib7 5557 10 first first JJ cord-005453-4057qib7 5557 11 complete complete JJ cord-005453-4057qib7 5557 12 response response NN cord-005453-4057qib7 5557 13 ( ( -LRB- cord-005453-4057qib7 5557 14 CR CR NNP cord-005453-4057qib7 5557 15 ) ) -RRB- cord-005453-4057qib7 5557 16 , , , cord-005453-4057qib7 5557 17 16 16 CD cord-005453-4057qib7 5557 18 ( ( -LRB- cord-005453-4057qib7 5557 19 23 23 CD cord-005453-4057qib7 5557 20 % % NN cord-005453-4057qib7 5557 21 ) ) -RRB- cord-005453-4057qib7 5557 22 patients patient NNS cord-005453-4057qib7 5557 23 in in IN cord-005453-4057qib7 5557 24 second second JJ cord-005453-4057qib7 5557 25 / / SYM cord-005453-4057qib7 5557 26 third third JJ cord-005453-4057qib7 5557 27 CR CR NNP cord-005453-4057qib7 5557 28 , , , cord-005453-4057qib7 5557 29 the the DT cord-005453-4057qib7 5557 30 others other NNS cord-005453-4057qib7 5557 31 in in IN cord-005453-4057qib7 5557 32 disease disease NN cord-005453-4057qib7 5557 33 control control NN cord-005453-4057qib7 5557 34 . . . cord-005453-4057qib7 5558 1 A a DT cord-005453-4057qib7 5558 2 median median JJ cord-005453-4057qib7 5558 3 dose dose NN cord-005453-4057qib7 5558 4 of of IN cord-005453-4057qib7 5558 5 7.0 7.0 CD cord-005453-4057qib7 5558 6 ( ( -LRB- cord-005453-4057qib7 5558 7 range range NNP cord-005453-4057qib7 5558 8 2 2 CD cord-005453-4057qib7 5558 9 - - SYM cord-005453-4057qib7 5558 10 15 15 CD cord-005453-4057qib7 5558 11 ) ) -RRB- cord-005453-4057qib7 5559 1 x x SYM cord-005453-4057qib7 5559 2 10 10 CD cord-005453-4057qib7 5559 3 ^ ^ SYM cord-005453-4057qib7 5559 4 6 6 CD cord-005453-4057qib7 5559 5 CD34 CD34 NNP cord-005453-4057qib7 5559 6 / / SYM cord-005453-4057qib7 5559 7 kg kg NNS cord-005453-4057qib7 5559 8 was be VBD cord-005453-4057qib7 5559 9 infused infuse VBN cord-005453-4057qib7 5559 10 . . . cord-005453-4057qib7 5560 1 Primary primary JJ cord-005453-4057qib7 5560 2 graft graft NN cord-005453-4057qib7 5560 3 failure failure NN cord-005453-4057qib7 5560 4 was be VBD cord-005453-4057qib7 5560 5 observed observe VBN cord-005453-4057qib7 5560 6 in in IN cord-005453-4057qib7 5560 7 one one CD cord-005453-4057qib7 5560 8 patient patient NN cord-005453-4057qib7 5560 9 . . . cord-005453-4057qib7 5561 1 All all DT cord-005453-4057qib7 5561 2 patients patient NNS cord-005453-4057qib7 5561 3 were be VBD cord-005453-4057qib7 5561 4 off off IN cord-005453-4057qib7 5561 5 MMF MMF NNP cord-005453-4057qib7 5561 6 on on IN cord-005453-4057qib7 5561 7 day day NN cord-005453-4057qib7 5561 8 +28 +28 NNS cord-005453-4057qib7 5561 9 , , , cord-005453-4057qib7 5561 10 the the DT cord-005453-4057qib7 5561 11 median median JJ cord-005453-4057qib7 5561 12 day day NN cord-005453-4057qib7 5561 13 of of IN cord-005453-4057qib7 5561 14 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 5561 15 discontinuation discontinuation NN cord-005453-4057qib7 5561 16 was be VBD cord-005453-4057qib7 5561 17 112 112 CD cord-005453-4057qib7 5562 1 ( ( -LRB- cord-005453-4057qib7 5562 2 range range NNP cord-005453-4057qib7 5562 3 39 39 CD cord-005453-4057qib7 5562 4 - - SYM cord-005453-4057qib7 5562 5 467 467 CD cord-005453-4057qib7 5562 6 ) ) -RRB- cord-005453-4057qib7 5562 7 . . . cord-005453-4057qib7 5563 1 Eight eight CD cord-005453-4057qib7 5563 2 out out IN cord-005453-4057qib7 5563 3 of of IN cord-005453-4057qib7 5563 4 71 71 CD cord-005453-4057qib7 5563 5 ( ( -LRB- cord-005453-4057qib7 5563 6 11 11 CD cord-005453-4057qib7 5563 7 % % NN cord-005453-4057qib7 5563 8 ) ) -RRB- cord-005453-4057qib7 5563 9 patients patient NNS cord-005453-4057qib7 5563 10 developed develop VBD cord-005453-4057qib7 5563 11 aGVHD aGVHD NNP cord-005453-4057qib7 5563 12 , , , cord-005453-4057qib7 5563 13 6 6 CD cord-005453-4057qib7 5563 14 ( ( -LRB- cord-005453-4057qib7 5563 15 8 8 CD cord-005453-4057qib7 5563 16 % % NN cord-005453-4057qib7 5563 17 ) ) -RRB- cord-005453-4057qib7 5563 18 of of IN cord-005453-4057qib7 5563 19 them -PRON- PRP cord-005453-4057qib7 5563 20 were be VBD cord-005453-4057qib7 5563 21 grade grade NN cord-005453-4057qib7 5563 22 II II NNP cord-005453-4057qib7 5563 23 - - HYPH cord-005453-4057qib7 5563 24 III III NNP cord-005453-4057qib7 5563 25 ; ; : cord-005453-4057qib7 5563 26 median median JJ cord-005453-4057qib7 5563 27 day day NN cord-005453-4057qib7 5563 28 of of IN cord-005453-4057qib7 5563 29 onset onset NN cord-005453-4057qib7 5563 30 was be VBD cord-005453-4057qib7 5563 31 day day NN cord-005453-4057qib7 5563 32 68 68 CD cord-005453-4057qib7 5564 1 ( ( -LRB- cord-005453-4057qib7 5564 2 range range NN cord-005453-4057qib7 5564 3 . . . cord-005453-4057qib7 5565 1 No no DT cord-005453-4057qib7 5565 2 grade grade NN cord-005453-4057qib7 5565 3 IV IV NNP cord-005453-4057qib7 5565 4 was be VBD cord-005453-4057qib7 5565 5 observed observe VBN cord-005453-4057qib7 5565 6 . . . cord-005453-4057qib7 5566 1 No no DT cord-005453-4057qib7 5566 2 cases case NNS cord-005453-4057qib7 5566 3 of of IN cord-005453-4057qib7 5566 4 late late JJ cord-005453-4057qib7 5566 5 - - HYPH cord-005453-4057qib7 5566 6 onset onset NN cord-005453-4057qib7 5566 7 aGVHD aGVHD NNP cord-005453-4057qib7 5566 8 were be VBD cord-005453-4057qib7 5566 9 reported report VBN cord-005453-4057qib7 5566 10 . . . cord-005453-4057qib7 5567 1 Cumulative cumulative JJ cord-005453-4057qib7 5567 2 incidence incidence NN cord-005453-4057qib7 5567 3 of of IN cord-005453-4057qib7 5567 4 cGVHD cGVHD NNP cord-005453-4057qib7 5567 5 was be VBD cord-005453-4057qib7 5567 6 8 8 CD cord-005453-4057qib7 5567 7 % % NN cord-005453-4057qib7 5567 8 ( ( -LRB- cord-005453-4057qib7 5567 9 6/ 6/ CD cord-005453-4057qib7 5567 10 71 71 CD cord-005453-4057qib7 5567 11 ) ) -RRB- cord-005453-4057qib7 5567 12 , , , cord-005453-4057qib7 5567 13 median median JJ cord-005453-4057qib7 5567 14 day day NN cord-005453-4057qib7 5567 15 of of IN cord-005453-4057qib7 5567 16 onset onset NN cord-005453-4057qib7 5567 17 was be VBD cord-005453-4057qib7 5567 18 162 162 CD cord-005453-4057qib7 5568 1 ( ( -LRB- cord-005453-4057qib7 5568 2 range range NNP cord-005453-4057qib7 5568 3 140 140 CD cord-005453-4057qib7 5568 4 - - SYM cord-005453-4057qib7 5568 5 268 268 CD cord-005453-4057qib7 5568 6 ) ) -RRB- cord-005453-4057qib7 5568 7 . . . cord-005453-4057qib7 5569 1 Systemic systemic JJ cord-005453-4057qib7 5569 2 treatments treatment NNS cord-005453-4057qib7 5569 3 were be VBD cord-005453-4057qib7 5569 4 required require VBN cord-005453-4057qib7 5569 5 , , , cord-005453-4057qib7 5569 6 but but CC cord-005453-4057qib7 5569 7 all all DT cord-005453-4057qib7 5569 8 patients patient NNS cord-005453-4057qib7 5569 9 were be VBD cord-005453-4057qib7 5569 10 able able JJ cord-005453-4057qib7 5569 11 to to TO cord-005453-4057qib7 5569 12 discontinue discontinue VB cord-005453-4057qib7 5569 13 immunosuppression immunosuppression NN cord-005453-4057qib7 5569 14 ( ( -LRB- cord-005453-4057qib7 5569 15 IS be VBZ cord-005453-4057qib7 5569 16 ) ) -RRB- cord-005453-4057qib7 5569 17 . . . cord-005453-4057qib7 5570 1 With with IN cord-005453-4057qib7 5570 2 a a DT cord-005453-4057qib7 5570 3 median median JJ cord-005453-4057qib7 5570 4 follow follow NN cord-005453-4057qib7 5570 5 - - HYPH cord-005453-4057qib7 5570 6 up up NN cord-005453-4057qib7 5570 7 of of IN cord-005453-4057qib7 5570 8 22 22 CD cord-005453-4057qib7 5570 9 ( ( -LRB- cord-005453-4057qib7 5570 10 range range NNP cord-005453-4057qib7 5570 11 4 4 CD cord-005453-4057qib7 5570 12 - - SYM cord-005453-4057qib7 5570 13 94 94 CD cord-005453-4057qib7 5570 14 ) ) -RRB- cord-005453-4057qib7 5570 15 months month NNS cord-005453-4057qib7 5570 16 , , , cord-005453-4057qib7 5570 17 EFS EFS NNP cord-005453-4057qib7 5570 18 was be VBD cord-005453-4057qib7 5570 19 58 58 CD cord-005453-4057qib7 5570 20 % % NN cord-005453-4057qib7 5570 21 , , , cord-005453-4057qib7 5570 22 cGVHD cGVHD NNP cord-005453-4057qib7 5570 23 - - HYPH cord-005453-4057qib7 5570 24 EFS EFS NNP cord-005453-4057qib7 5570 25 was be VBD cord-005453-4057qib7 5570 26 52 52 CD cord-005453-4057qib7 5570 27 % % NN cord-005453-4057qib7 5570 28 and and CC cord-005453-4057qib7 5570 29 OS OS NNP cord-005453-4057qib7 5570 30 was be VBD cord-005453-4057qib7 5570 31 72 72 CD cord-005453-4057qib7 5570 32 % % NN cord-005453-4057qib7 5570 33 . . . cord-005453-4057qib7 5571 1 Non non JJ cord-005453-4057qib7 5571 2 - - JJ cord-005453-4057qib7 5571 3 relapse relapse JJ cord-005453-4057qib7 5571 4 mortality mortality NN cord-005453-4057qib7 5571 5 ( ( -LRB- cord-005453-4057qib7 5571 6 NRM NRM NNP cord-005453-4057qib7 5571 7 ) ) -RRB- cord-005453-4057qib7 5571 8 was be VBD cord-005453-4057qib7 5571 9 3 3 CD cord-005453-4057qib7 5571 10 % % NN cord-005453-4057qib7 5571 11 ( ( -LRB- cord-005453-4057qib7 5571 12 2/71 2/71 CD cord-005453-4057qib7 5571 13 ) ) -RRB- cord-005453-4057qib7 5571 14 : : : cord-005453-4057qib7 5572 1 2 2 CD cord-005453-4057qib7 5572 2 patients patient NNS cord-005453-4057qib7 5572 3 died die VBD cord-005453-4057qib7 5572 4 because because IN cord-005453-4057qib7 5572 5 of of IN cord-005453-4057qib7 5572 6 multidrug multidrug NN cord-005453-4057qib7 5572 7 resistant resistant JJ cord-005453-4057qib7 5572 8 bacteria bacteria NNS cord-005453-4057qib7 5572 9 septicemia septicemia NN cord-005453-4057qib7 5572 10 . . . cord-005453-4057qib7 5573 1 Nowadays nowadays RB cord-005453-4057qib7 5573 2 41 41 CD cord-005453-4057qib7 5573 3 patients patient NNS cord-005453-4057qib7 5573 4 are be VBP cord-005453-4057qib7 5573 5 alive alive JJ cord-005453-4057qib7 5573 6 with with IN cord-005453-4057qib7 5573 7 no no DT cord-005453-4057qib7 5573 8 evidence evidence NN cord-005453-4057qib7 5573 9 of of IN cord-005453-4057qib7 5573 10 disease disease NN cord-005453-4057qib7 5573 11 , , , cord-005453-4057qib7 5573 12 being be VBG cord-005453-4057qib7 5573 13 continuously continuously RB cord-005453-4057qib7 5573 14 off off RB cord-005453-4057qib7 5573 15 IS be VBZ cord-005453-4057qib7 5573 16 and and CC cord-005453-4057qib7 5573 17 completely completely RB cord-005453-4057qib7 5573 18 reintegrated reintegrate VBN cord-005453-4057qib7 5573 19 in in IN cord-005453-4057qib7 5573 20 their -PRON- PRP$ cord-005453-4057qib7 5573 21 normal normal JJ cord-005453-4057qib7 5573 22 daily daily JJ cord-005453-4057qib7 5573 23 life life NN cord-005453-4057qib7 5573 24 activities activity NNS cord-005453-4057qib7 5573 25 . . . cord-005453-4057qib7 5574 1 Conclusions conclusion NNS cord-005453-4057qib7 5574 2 : : : cord-005453-4057qib7 5575 1 The the DT cord-005453-4057qib7 5575 2 updated update VBN cord-005453-4057qib7 5575 3 reported report VBD cord-005453-4057qib7 5575 4 results result NNS cord-005453-4057qib7 5575 5 confirm confirm VBP cord-005453-4057qib7 5575 6 , , , cord-005453-4057qib7 5575 7 in in IN cord-005453-4057qib7 5575 8 a a DT cord-005453-4057qib7 5575 9 larger large JJR cord-005453-4057qib7 5575 10 cohort cohort NN cord-005453-4057qib7 5575 11 of of IN cord-005453-4057qib7 5575 12 patients patient NNS cord-005453-4057qib7 5575 13 with with IN cord-005453-4057qib7 5575 14 a a DT cord-005453-4057qib7 5575 15 longer long RBR cord-005453-4057qib7 5575 16 follow follow NN cord-005453-4057qib7 5575 17 - - HYPH cord-005453-4057qib7 5575 18 up up NN cord-005453-4057qib7 5575 19 , , , cord-005453-4057qib7 5575 20 that that IN cord-005453-4057qib7 5575 21 ptCy ptcy RB cord-005453-4057qib7 5575 22 after after IN cord-005453-4057qib7 5575 23 PBSC PBSC NNP cord-005453-4057qib7 5575 24 - - HYPH cord-005453-4057qib7 5575 25 HCT HCT NNP cord-005453-4057qib7 5575 26 is be VBZ cord-005453-4057qib7 5575 27 highly highly RB cord-005453-4057qib7 5575 28 active active JJ cord-005453-4057qib7 5575 29 in in IN cord-005453-4057qib7 5575 30 aGVHD aGVHD NNP cord-005453-4057qib7 5575 31 and and CC cord-005453-4057qib7 5575 32 cGVHD cGVHD NNP cord-005453-4057qib7 5575 33 prevention prevention NN cord-005453-4057qib7 5575 34 with with IN cord-005453-4057qib7 5575 35 extremely extremely RB cord-005453-4057qib7 5575 36 limited limited JJ cord-005453-4057qib7 5575 37 NRM NRM NNP cord-005453-4057qib7 5575 38 . . . cord-005453-4057qib7 5576 1 This this DT cord-005453-4057qib7 5576 2 strategy strategy NN cord-005453-4057qib7 5576 3 , , , cord-005453-4057qib7 5576 4 not not RB cord-005453-4057qib7 5576 5 only only RB cord-005453-4057qib7 5576 6 allowed allow VBN cord-005453-4057qib7 5576 7 earlier early JJR cord-005453-4057qib7 5576 8 discontinuation discontinuation NN cord-005453-4057qib7 5576 9 of of IN cord-005453-4057qib7 5576 10 immunosuppression immunosuppression NN cord-005453-4057qib7 5576 11 , , , cord-005453-4057qib7 5576 12 but but CC cord-005453-4057qib7 5576 13 also also RB cord-005453-4057qib7 5576 14 reduced reduce VBD cord-005453-4057qib7 5576 15 the the DT cord-005453-4057qib7 5576 16 overall overall JJ cord-005453-4057qib7 5576 17 time time NN cord-005453-4057qib7 5576 18 of of IN cord-005453-4057qib7 5576 19 exposure exposure NN cord-005453-4057qib7 5576 20 to to IN cord-005453-4057qib7 5576 21 IS be VBZ cord-005453-4057qib7 5576 22 for for IN cord-005453-4057qib7 5576 23 most most JJS cord-005453-4057qib7 5576 24 of of IN cord-005453-4057qib7 5576 25 the the DT cord-005453-4057qib7 5576 26 patients patient NNS cord-005453-4057qib7 5576 27 . . . cord-005453-4057qib7 5577 1 All all PDT cord-005453-4057qib7 5577 2 these these DT cord-005453-4057qib7 5577 3 features feature NNS cord-005453-4057qib7 5577 4 might may MD cord-005453-4057qib7 5577 5 contribute contribute VB cord-005453-4057qib7 5577 6 , , , cord-005453-4057qib7 5577 7 in in IN cord-005453-4057qib7 5577 8 the the DT cord-005453-4057qib7 5577 9 future future NN cord-005453-4057qib7 5577 10 , , , cord-005453-4057qib7 5577 11 to to TO cord-005453-4057qib7 5577 12 transform transform VB cord-005453-4057qib7 5577 13 HCT hct NN cord-005453-4057qib7 5577 14 into into IN cord-005453-4057qib7 5577 15 a a DT cord-005453-4057qib7 5577 16 safe safe JJ cord-005453-4057qib7 5577 17 immunologic immunologic JJ cord-005453-4057qib7 5577 18 platform platform NN cord-005453-4057qib7 5577 19 that that WDT cord-005453-4057qib7 5577 20 may may MD cord-005453-4057qib7 5577 21 be be VB cord-005453-4057qib7 5577 22 combined combine VBN cord-005453-4057qib7 5577 23 with with IN cord-005453-4057qib7 5577 24 advanced advanced JJ cord-005453-4057qib7 5577 25 form form NN cord-005453-4057qib7 5577 26 of of IN cord-005453-4057qib7 5577 27 cellular cellular JJ cord-005453-4057qib7 5577 28 therapies therapy NNS cord-005453-4057qib7 5577 29 ( ( -LRB- cord-005453-4057qib7 5577 30 CAR CAR NNP cord-005453-4057qib7 5577 31 - - HYPH cord-005453-4057qib7 5577 32 Tcells Tcells NNP cord-005453-4057qib7 5577 33 ) ) -RRB- cord-005453-4057qib7 5577 34 , , , cord-005453-4057qib7 5577 35 aiming aim VBG cord-005453-4057qib7 5577 36 to to TO cord-005453-4057qib7 5577 37 increase increase VB cord-005453-4057qib7 5577 38 safely safely RB cord-005453-4057qib7 5577 39 the the DT cord-005453-4057qib7 5577 40 graftversus graftversus NN cord-005453-4057qib7 5577 41 - - HYPH cord-005453-4057qib7 5577 42 tumor tumor NN cord-005453-4057qib7 5577 43 effect effect NN cord-005453-4057qib7 5577 44 . . . cord-005453-4057qib7 5578 1 Clinical clinical JJ cord-005453-4057qib7 5578 2 Methods method NNS cord-005453-4057qib7 5578 3 : : : cord-005453-4057qib7 5578 4 Pediatric pediatric JJ cord-005453-4057qib7 5578 5 patients patient NNS cord-005453-4057qib7 5578 6 ( ( -LRB- cord-005453-4057qib7 5578 7 0 0 CD cord-005453-4057qib7 5578 8 - - SYM cord-005453-4057qib7 5578 9 21 21 CD cord-005453-4057qib7 5578 10 years year NNS cord-005453-4057qib7 5578 11 ) ) -RRB- cord-005453-4057qib7 5578 12 with with IN cord-005453-4057qib7 5578 13 NMD NMD NNP cord-005453-4057qib7 5578 14 undergoing undergo VBG cord-005453-4057qib7 5578 15 unrelated unrelated JJ cord-005453-4057qib7 5578 16 HCT HCT NNP cord-005453-4057qib7 5578 17 were be VBD cord-005453-4057qib7 5578 18 eligible eligible JJ cord-005453-4057qib7 5578 19 for for IN cord-005453-4057qib7 5578 20 this this DT cord-005453-4057qib7 5578 21 single single JJ cord-005453-4057qib7 5578 22 center center NN cord-005453-4057qib7 5578 23 , , , cord-005453-4057qib7 5578 24 phase phase NN cord-005453-4057qib7 5578 25 I -PRON- PRP cord-005453-4057qib7 5578 26 trial trial NN cord-005453-4057qib7 5578 27 . . . cord-005453-4057qib7 5579 1 Following follow VBG cord-005453-4057qib7 5579 2 reduced reduced JJ cord-005453-4057qib7 5579 3 intensity intensity NN cord-005453-4057qib7 5579 4 conditioning conditioning NN cord-005453-4057qib7 5579 5 , , , cord-005453-4057qib7 5579 6 abatacept abatacept NNP cord-005453-4057qib7 5579 7 ( ( -LRB- cord-005453-4057qib7 5579 8 10 10 CD cord-005453-4057qib7 5579 9 mg mg NNP cord-005453-4057qib7 5579 10 / / SYM cord-005453-4057qib7 5579 11 kg kg NNP cord-005453-4057qib7 5579 12 IV IV NNP cord-005453-4057qib7 5579 13 on on IN cord-005453-4057qib7 5579 14 days day NNS cord-005453-4057qib7 5579 15 -1 -1 NNP cord-005453-4057qib7 5579 16 , , , cord-005453-4057qib7 5579 17 +5 +5 NN cord-005453-4057qib7 5579 18 , , , cord-005453-4057qib7 5579 19 +14 +14 CD cord-005453-4057qib7 5579 20 , , , cord-005453-4057qib7 5579 21 +28 +28 CD cord-005453-4057qib7 5579 22 ) ) -RRB- cord-005453-4057qib7 5579 23 was be VBD cord-005453-4057qib7 5579 24 added add VBN cord-005453-4057qib7 5579 25 to to IN cord-005453-4057qib7 5579 26 standard standard JJ cord-005453-4057qib7 5579 27 GVHD GVHD NNP cord-005453-4057qib7 5579 28 prophylaxis prophylaxis NN cord-005453-4057qib7 5579 29 ( ( -LRB- cord-005453-4057qib7 5579 30 cyclosporine cyclosporine NN cord-005453-4057qib7 5579 31 , , , cord-005453-4057qib7 5579 32 mycophenolate mycophenolate NNP cord-005453-4057qib7 5579 33 mofetil mofetil NNP cord-005453-4057qib7 5579 34 [ [ -LRB- cord-005453-4057qib7 5579 35 MMF MMF NNP cord-005453-4057qib7 5579 36 ] ] -RRB- cord-005453-4057qib7 5579 37 ) ) -RRB- cord-005453-4057qib7 5579 38 . . . cord-005453-4057qib7 5580 1 Patients patient NNS cord-005453-4057qib7 5580 2 were be VBD cord-005453-4057qib7 5580 3 followed follow VBN cord-005453-4057qib7 5580 4 for for IN cord-005453-4057qib7 5580 5 2 2 CD cord-005453-4057qib7 5580 6 years year NNS cord-005453-4057qib7 5580 7 for for IN cord-005453-4057qib7 5580 8 standard standard JJ cord-005453-4057qib7 5580 9 HCT HCT NNP cord-005453-4057qib7 5580 10 outcomes outcome NNS cord-005453-4057qib7 5580 11 . . . cord-005453-4057qib7 5581 1 [ [ -LRB- cord-005453-4057qib7 5581 2 [ [ -LRB- cord-005453-4057qib7 5581 3 P257 P257 NNP cord-005453-4057qib7 5581 4 Image image NN cord-005453-4057qib7 5581 5 ] ] -RRB- cord-005453-4057qib7 5581 6 1 1 CD cord-005453-4057qib7 5581 7 . . . cord-005453-4057qib7 5582 1 Figure figure NN cord-005453-4057qib7 5582 2 1 1 CD cord-005453-4057qib7 5582 3 Results result NNS cord-005453-4057qib7 5583 1 : : : cord-005453-4057qib7 5583 2 Since since IN cord-005453-4057qib7 5583 3 June June NNP cord-005453-4057qib7 5583 4 2014 2014 CD cord-005453-4057qib7 5583 5 , , , cord-005453-4057qib7 5583 6 10 10 CD cord-005453-4057qib7 5583 7 patients patient NNS cord-005453-4057qib7 5583 8 have have VBP cord-005453-4057qib7 5583 9 been be VBN cord-005453-4057qib7 5583 10 enrolled enrol VBN cord-005453-4057qib7 5583 11 and and CC cord-005453-4057qib7 5583 12 transplanted transplant VBN cord-005453-4057qib7 5583 13 ( ( -LRB- cord-005453-4057qib7 5583 14 Table table NN cord-005453-4057qib7 5583 15 1 1 CD cord-005453-4057qib7 5583 16 , , , cord-005453-4057qib7 5583 17 excluding exclude VBG cord-005453-4057qib7 5583 18 # # $ cord-005453-4057qib7 5583 19 7 7 CD cord-005453-4057qib7 5583 20 ) ) -RRB- cord-005453-4057qib7 5583 21 . . . cord-005453-4057qib7 5584 1 Donor donor NN cord-005453-4057qib7 5584 2 source source NN cord-005453-4057qib7 5584 3 was be VBD cord-005453-4057qib7 5584 4 bone bone NN cord-005453-4057qib7 5584 5 marrow marrow NN cord-005453-4057qib7 5584 6 in in IN cord-005453-4057qib7 5584 7 all all DT cord-005453-4057qib7 5584 8 . . . cord-005453-4057qib7 5585 1 With with IN cord-005453-4057qib7 5585 2 median median JJ cord-005453-4057qib7 5585 3 follow follow NN cord-005453-4057qib7 5585 4 - - HYPH cord-005453-4057qib7 5585 5 up up NN cord-005453-4057qib7 5585 6 of of IN cord-005453-4057qib7 5585 7 3.5 3.5 CD cord-005453-4057qib7 5585 8 years year NNS cord-005453-4057qib7 5585 9 , , , cord-005453-4057qib7 5585 10 8 8 CD cord-005453-4057qib7 5585 11 of of IN cord-005453-4057qib7 5585 12 10 10 CD cord-005453-4057qib7 5585 13 patients patient NNS cord-005453-4057qib7 5585 14 survive survive VBP cord-005453-4057qib7 5585 15 without without IN cord-005453-4057qib7 5585 16 disease disease NN cord-005453-4057qib7 5585 17 . . . cord-005453-4057qib7 5586 1 Initial initial JJ cord-005453-4057qib7 5586 2 engraftment engraftment NN cord-005453-4057qib7 5586 3 was be VBD cord-005453-4057qib7 5586 4 successful successful JJ cord-005453-4057qib7 5586 5 in in IN cord-005453-4057qib7 5586 6 9 9 CD cord-005453-4057qib7 5586 7 , , , cord-005453-4057qib7 5586 8 at at IN cord-005453-4057qib7 5586 9 a a DT cord-005453-4057qib7 5586 10 median median NN cord-005453-4057qib7 5586 11 of of IN cord-005453-4057qib7 5586 12 20 20 CD cord-005453-4057qib7 5586 13 and and CC cord-005453-4057qib7 5586 14 16 16 CD cord-005453-4057qib7 5586 15 days day NNS cord-005453-4057qib7 5586 16 , , , cord-005453-4057qib7 5586 17 for for IN cord-005453-4057qib7 5586 18 neutrophils neutrophil NNS cord-005453-4057qib7 5586 19 and and CC cord-005453-4057qib7 5586 20 platelets platelet NNS cord-005453-4057qib7 5586 21 respectively respectively RB cord-005453-4057qib7 5586 22 . . . cord-005453-4057qib7 5587 1 One one CD cord-005453-4057qib7 5587 2 patient patient NN cord-005453-4057qib7 5587 3 ( ( -LRB- cord-005453-4057qib7 5587 4 5 5 LS cord-005453-4057qib7 5587 5 ) ) -RRB- cord-005453-4057qib7 5587 6 had have VBD cord-005453-4057qib7 5587 7 secondary secondary JJ cord-005453-4057qib7 5587 8 graft graft NN cord-005453-4057qib7 5587 9 rejection rejection NN cord-005453-4057qib7 5587 10 in in IN cord-005453-4057qib7 5587 11 the the DT cord-005453-4057qib7 5587 12 setting setting NN cord-005453-4057qib7 5587 13 of of IN cord-005453-4057qib7 5587 14 viral viral JJ cord-005453-4057qib7 5587 15 reactivation reactivation NN cord-005453-4057qib7 5587 16 ( ( -LRB- cord-005453-4057qib7 5587 17 CMV CMV NNP cord-005453-4057qib7 5587 18 / / SYM cord-005453-4057qib7 5587 19 EBV EBV NNP cord-005453-4057qib7 5587 20 ) ) -RRB- cord-005453-4057qib7 5587 21 , , , cord-005453-4057qib7 5587 22 with with IN cord-005453-4057qib7 5587 23 successful successful JJ cord-005453-4057qib7 5587 24 engraftment engraftment NN cord-005453-4057qib7 5587 25 following follow VBG cord-005453-4057qib7 5587 26 a a DT cord-005453-4057qib7 5587 27 2 2 CD cord-005453-4057qib7 5587 28 nd nd NNP cord-005453-4057qib7 5587 29 unrelated unrelated JJ cord-005453-4057qib7 5587 30 HCT HCT NNP cord-005453-4057qib7 5587 31 . . . cord-005453-4057qib7 5588 1 In in IN cord-005453-4057qib7 5588 2 8 8 CD cord-005453-4057qib7 5588 3 engrafted engraft VBN cord-005453-4057qib7 5588 4 patients patient NNS cord-005453-4057qib7 5588 5 , , , cord-005453-4057qib7 5588 6 myeloid myeloid JJ cord-005453-4057qib7 5588 7 ( ( -LRB- cord-005453-4057qib7 5588 8 CD33 CD33 NNP cord-005453-4057qib7 5588 9 ) ) -RRB- cord-005453-4057qib7 5588 10 chimerism chimerism NN cord-005453-4057qib7 5588 11 was be VBD cord-005453-4057qib7 5588 12 100 100 CD cord-005453-4057qib7 5588 13 % % NN cord-005453-4057qib7 5588 14 at at IN cord-005453-4057qib7 5588 15 all all DT cord-005453-4057qib7 5588 16 timepoints timepoint NNS cord-005453-4057qib7 5588 17 ; ; : cord-005453-4057qib7 5588 18 T t NN cord-005453-4057qib7 5588 19 - - HYPH cord-005453-4057qib7 5588 20 lymphoid lymphoid NNP cord-005453-4057qib7 5588 21 ( ( -LRB- cord-005453-4057qib7 5588 22 CD3 CD3 NNP cord-005453-4057qib7 5588 23 ) ) -RRB- cord-005453-4057qib7 5588 24 chimerism chimerism NN cord-005453-4057qib7 5588 25 was be VBD cord-005453-4057qib7 5588 26 mixed mixed JJ cord-005453-4057qib7 5588 27 but but CC cord-005453-4057qib7 5588 28 reached reach VBN cord-005453-4057qib7 5588 29 > > XX cord-005453-4057qib7 5589 1 /=95 /=95 : cord-005453-4057qib7 5589 2 % % NN cord-005453-4057qib7 5589 3 ( ( -LRB- cord-005453-4057qib7 5589 4 Figure figure NN cord-005453-4057qib7 5589 5 1 1 CD cord-005453-4057qib7 5589 6 ) ) -RRB- cord-005453-4057qib7 5589 7 . . . cord-005453-4057qib7 5590 1 One one CD cord-005453-4057qib7 5590 2 patient patient NN cord-005453-4057qib7 5590 3 ( ( -LRB- cord-005453-4057qib7 5590 4 7 7 CD cord-005453-4057qib7 5590 5 ) ) -RRB- cord-005453-4057qib7 5590 6 with with IN cord-005453-4057qib7 5590 7 SAA SAA NNP cord-005453-4057qib7 5590 8 had have VBD cord-005453-4057qib7 5590 9 primary primary JJ cord-005453-4057qib7 5590 10 graft graft NN cord-005453-4057qib7 5590 11 rejection rejection NN cord-005453-4057qib7 5590 12 in in IN cord-005453-4057qib7 5590 13 the the DT cord-005453-4057qib7 5590 14 setting setting NN cord-005453-4057qib7 5590 15 of of IN cord-005453-4057qib7 5590 16 inadequate inadequate JJ cord-005453-4057qib7 5590 17 TNC TNC NNP cord-005453-4057qib7 5590 18 dose dose NN cord-005453-4057qib7 5590 19 ( ( -LRB- cord-005453-4057qib7 5590 20 0.5 0.5 CD cord-005453-4057qib7 5590 21 x x SYM cord-005453-4057qib7 5590 22 10 10 CD cord-005453-4057qib7 5590 23 8 8 CD cord-005453-4057qib7 5590 24 /kg /kg CD cord-005453-4057qib7 5590 25 ) ) -RRB- cord-005453-4057qib7 5590 26 and and CC cord-005453-4057qib7 5590 27 died die VBD cord-005453-4057qib7 5590 28 from from IN cord-005453-4057qib7 5590 29 marrow marrow NN cord-005453-4057qib7 5590 30 aplasia aplasia NNP cord-005453-4057qib7 5590 31 / / SYM cord-005453-4057qib7 5590 32 infection infection NN cord-005453-4057qib7 5590 33 despite despite IN cord-005453-4057qib7 5590 34 2 2 CD cord-005453-4057qib7 5590 35 nd nd NNP cord-005453-4057qib7 5590 36 HCT HCT NNP cord-005453-4057qib7 5590 37 . . . cord-005453-4057qib7 5591 1 A a DT cord-005453-4057qib7 5591 2 second second JJ cord-005453-4057qib7 5591 3 death death NN cord-005453-4057qib7 5591 4 from from IN cord-005453-4057qib7 5591 5 Wilms Wilms NNP cord-005453-4057qib7 5591 6 ' ' POS cord-005453-4057qib7 5591 7 tumor tumor NN cord-005453-4057qib7 5591 8 occurred occur VBD cord-005453-4057qib7 5591 9 17 17 CD cord-005453-4057qib7 5591 10 months month NNS cord-005453-4057qib7 5591 11 post post VBP cord-005453-4057qib7 5591 12 successful successful JJ cord-005453-4057qib7 5591 13 HCT hct NN cord-005453-4057qib7 5591 14 , , , cord-005453-4057qib7 5591 15 in in IN cord-005453-4057qib7 5591 16 a a DT cord-005453-4057qib7 5591 17 patient patient NN cord-005453-4057qib7 5591 18 ( ( -LRB- cord-005453-4057qib7 5591 19 1 1 CD cord-005453-4057qib7 5591 20 ) ) -RRB- cord-005453-4057qib7 5591 21 with with IN cord-005453-4057qib7 5591 22 DBA dba NN cord-005453-4057qib7 5591 23 and and CC cord-005453-4057qib7 5591 24 constitutional constitutional JJ cord-005453-4057qib7 5591 25 chromosome chromosome NN cord-005453-4057qib7 5591 26 abnormality abnormality NN cord-005453-4057qib7 5591 27 . . . cord-005453-4057qib7 5592 1 Except except IN cord-005453-4057qib7 5592 2 patient patient NN cord-005453-4057qib7 5592 3 7 7 CD cord-005453-4057qib7 5592 4 , , , cord-005453-4057qib7 5592 5 all all DT cord-005453-4057qib7 5592 6 patients patient NNS cord-005453-4057qib7 5592 7 received receive VBD cord-005453-4057qib7 5592 8 4 4 CD cord-005453-4057qib7 5592 9 doses dose NNS cord-005453-4057qib7 5592 10 of of IN cord-005453-4057qib7 5592 11 abatacept abatacept NNP cord-005453-4057qib7 5592 12 , , , cord-005453-4057qib7 5592 13 which which WDT cord-005453-4057qib7 5592 14 was be VBD cord-005453-4057qib7 5592 15 well well RB cord-005453-4057qib7 5592 16 tolerated tolerate VBN cord-005453-4057qib7 5592 17 , , , cord-005453-4057qib7 5592 18 with with IN cord-005453-4057qib7 5592 19 all all DT cord-005453-4057qib7 5592 20 severe severe JJ cord-005453-4057qib7 5592 21 adverse adverse JJ cord-005453-4057qib7 5592 22 events event NNS cord-005453-4057qib7 5592 23 expected expect VBN cord-005453-4057qib7 5592 24 for for IN cord-005453-4057qib7 5592 25 a a DT cord-005453-4057qib7 5592 26 HCT HCT NNP cord-005453-4057qib7 5592 27 population population NN cord-005453-4057qib7 5592 28 . . . cord-005453-4057qib7 5593 1 CMV CMV NNP cord-005453-4057qib7 5593 2 and and CC cord-005453-4057qib7 5593 3 EBV EBV NNP cord-005453-4057qib7 5593 4 reactivation reactivation NN cord-005453-4057qib7 5593 5 occurred occur VBD cord-005453-4057qib7 5593 6 in in IN cord-005453-4057qib7 5593 7 3 3 CD cord-005453-4057qib7 5593 8 patients patient NNS cord-005453-4057qib7 5593 9 each each DT cord-005453-4057qib7 5593 10 , , , cord-005453-4057qib7 5593 11 with with IN cord-005453-4057qib7 5593 12 resolution resolution NN cord-005453-4057qib7 5593 13 using use VBG cord-005453-4057qib7 5593 14 standard standard JJ cord-005453-4057qib7 5593 15 anti anti JJ cord-005453-4057qib7 5593 16 - - JJ cord-005453-4057qib7 5593 17 viral viral JJ cord-005453-4057qib7 5593 18 therapy therapy NN cord-005453-4057qib7 5593 19 . . . cord-005453-4057qib7 5594 1 One one CD cord-005453-4057qib7 5594 2 patient patient NN cord-005453-4057qib7 5594 3 ( ( -LRB- cord-005453-4057qib7 5594 4 6 6 CD cord-005453-4057qib7 5594 5 ) ) -RRB- cord-005453-4057qib7 5594 6 was be VBD cord-005453-4057qib7 5594 7 diagnosed diagnose VBN cord-005453-4057qib7 5594 8 with with IN cord-005453-4057qib7 5594 9 EBV EBV NNP cord-005453-4057qib7 5594 10 - - HYPH cord-005453-4057qib7 5594 11 driven drive VBN cord-005453-4057qib7 5594 12 post post JJ cord-005453-4057qib7 5594 13 - - JJ cord-005453-4057qib7 5594 14 transplant transplant JJ cord-005453-4057qib7 5594 15 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 5594 16 disease disease NN cord-005453-4057qib7 5594 17 , , , cord-005453-4057qib7 5594 18 which which WDT cord-005453-4057qib7 5594 19 responded respond VBD cord-005453-4057qib7 5594 20 to to IN cord-005453-4057qib7 5594 21 rituximab rituximab NN cord-005453-4057qib7 5594 22 and and CC cord-005453-4057qib7 5594 23 immune immune JJ cord-005453-4057qib7 5594 24 suppression suppression NN cord-005453-4057qib7 5594 25 withdrawal withdrawal NN cord-005453-4057qib7 5594 26 . . . cord-005453-4057qib7 5595 1 No no DT cord-005453-4057qib7 5595 2 patients patient NNS cord-005453-4057qib7 5595 3 developed develop VBD cord-005453-4057qib7 5595 4 severe severe JJ cord-005453-4057qib7 5595 5 acute acute JJ cord-005453-4057qib7 5595 6 ( ( -LRB- cord-005453-4057qib7 5595 7 grade grade NN cord-005453-4057qib7 5595 8 III III NNP cord-005453-4057qib7 5595 9 - - HYPH cord-005453-4057qib7 5595 10 IV IV NNP cord-005453-4057qib7 5595 11 ) ) -RRB- cord-005453-4057qib7 5595 12 or or CC cord-005453-4057qib7 5595 13 chronic chronic JJ cord-005453-4057qib7 5595 14 GVHD GVHD NNP cord-005453-4057qib7 5595 15 ( ( -LRB- cord-005453-4057qib7 5595 16 Table table NN cord-005453-4057qib7 5595 17 1 1 CD cord-005453-4057qib7 5595 18 ) ) -RRB- cord-005453-4057qib7 5595 19 , , , cord-005453-4057qib7 5595 20 and and CC cord-005453-4057qib7 5595 21 no no DT cord-005453-4057qib7 5595 22 patients patient NNS cord-005453-4057qib7 5595 23 required require VBD cord-005453-4057qib7 5595 24 systemic systemic JJ cord-005453-4057qib7 5595 25 immune immune JJ cord-005453-4057qib7 5595 26 suppression suppression NN cord-005453-4057qib7 5595 27 at at IN cord-005453-4057qib7 5595 28 > > XX cord-005453-4057qib7 5595 29 1 1 CD cord-005453-4057qib7 5595 30 year year NN cord-005453-4057qib7 5595 31 . . . cord-005453-4057qib7 5596 1 Conclusions conclusion NNS cord-005453-4057qib7 5596 2 : : : cord-005453-4057qib7 5597 1 These these DT cord-005453-4057qib7 5597 2 preliminary preliminary JJ cord-005453-4057qib7 5597 3 data datum NNS cord-005453-4057qib7 5597 4 suggest suggest VBP cord-005453-4057qib7 5597 5 that that IN cord-005453-4057qib7 5597 6 abatacept abatacept NNP cord-005453-4057qib7 5597 7 can can MD cord-005453-4057qib7 5597 8 be be VB cord-005453-4057qib7 5597 9 safely safely RB cord-005453-4057qib7 5597 10 added add VBN cord-005453-4057qib7 5597 11 to to IN cord-005453-4057qib7 5597 12 cyclosporine cyclosporine NN cord-005453-4057qib7 5597 13 and and CC cord-005453-4057qib7 5597 14 MMF MMF NNP cord-005453-4057qib7 5597 15 GVHD GVHD NNP cord-005453-4057qib7 5597 16 prophylaxis prophylaxis NN cord-005453-4057qib7 5597 17 in in IN cord-005453-4057qib7 5597 18 pediatric pediatric JJ cord-005453-4057qib7 5597 19 patients patient NNS cord-005453-4057qib7 5597 20 with with IN cord-005453-4057qib7 5597 21 bone bone NN cord-005453-4057qib7 5597 22 marrow marrow NN cord-005453-4057qib7 5597 23 failure failure NN cord-005453-4057qib7 5597 24 undergoing undergo VBG cord-005453-4057qib7 5597 25 unrelated unrelated JJ cord-005453-4057qib7 5597 26 donor donor NN cord-005453-4057qib7 5597 27 HCT hct NN cord-005453-4057qib7 5597 28 , , , cord-005453-4057qib7 5597 29 with with IN cord-005453-4057qib7 5597 30 encouraging encouraging JJ cord-005453-4057qib7 5597 31 rates rate NNS cord-005453-4057qib7 5597 32 of of IN cord-005453-4057qib7 5597 33 GVHD GVHD NNP cord-005453-4057qib7 5597 34 despite despite IN cord-005453-4057qib7 5597 35 half half NN cord-005453-4057qib7 5597 36 of of IN cord-005453-4057qib7 5597 37 patients patient NNS cord-005453-4057qib7 5597 38 having have VBG cord-005453-4057qib7 5597 39 a a DT cord-005453-4057qib7 5597 40 mismatched mismatched JJ cord-005453-4057qib7 5597 41 ( ( -LRB- cord-005453-4057qib7 5597 42 7/8 7/8 CD cord-005453-4057qib7 5597 43 ) ) -RRB- cord-005453-4057qib7 5597 44 donor donor NN cord-005453-4057qib7 5597 45 . . . cord-005453-4057qib7 5598 1 Given give VBN cord-005453-4057qib7 5598 2 the the DT cord-005453-4057qib7 5598 3 higher high JJR cord-005453-4057qib7 5598 4 risk risk NN cord-005453-4057qib7 5598 5 of of IN cord-005453-4057qib7 5598 6 graft graft NN cord-005453-4057qib7 5598 7 rejection rejection NN cord-005453-4057qib7 5598 8 in in IN cord-005453-4057qib7 5598 9 this this DT cord-005453-4057qib7 5598 10 non non JJ cord-005453-4057qib7 5598 11 - - JJ cord-005453-4057qib7 5598 12 malignant malignant JJ cord-005453-4057qib7 5598 13 cohort cohort NN cord-005453-4057qib7 5598 14 , , , cord-005453-4057qib7 5598 15 rejection rejection NN cord-005453-4057qib7 5598 16 ( ( -LRB- cord-005453-4057qib7 5598 17 in in IN cord-005453-4057qib7 5598 18 addition addition NN cord-005453-4057qib7 5598 19 to to IN cord-005453-4057qib7 5598 20 GVHD GVHD NNP cord-005453-4057qib7 5598 21 ) ) -RRB- cord-005453-4057qib7 5598 22 will will MD cord-005453-4057qib7 5598 23 be be VB cord-005453-4057qib7 5598 24 a a DT cord-005453-4057qib7 5598 25 primary primary JJ cord-005453-4057qib7 5598 26 focus focus NN cord-005453-4057qib7 5598 27 in in IN cord-005453-4057qib7 5598 28 our -PRON- PRP$ cord-005453-4057qib7 5598 29 subsequent subsequent JJ cord-005453-4057qib7 5598 30 multi multi JJ cord-005453-4057qib7 5598 31 - - JJ cord-005453-4057qib7 5598 32 center center JJ cord-005453-4057qib7 5598 33 , , , cord-005453-4057qib7 5598 34 phase phase NN cord-005453-4057qib7 5598 35 2 2 CD cord-005453-4057qib7 5598 36 trial trial NN cord-005453-4057qib7 5598 37 . . . cord-005453-4057qib7 5599 1 Clinical clinical JJ cord-005453-4057qib7 5599 2 Trial Trial NNP cord-005453-4057qib7 5599 3 Registry Registry NNP cord-005453-4057qib7 5599 4 : : : cord-005453-4057qib7 5599 5 ClinicalTrials ClinicalTrials NNP cord-005453-4057qib7 5599 6 . . . cord-005453-4057qib7 5600 1 GvHD GvHD NNP cord-005453-4057qib7 5600 2 and and CC cord-005453-4057qib7 5600 3 may may MD cord-005453-4057qib7 5600 4 to to TO cord-005453-4057qib7 5600 5 have have VB cord-005453-4057qib7 5600 6 be be VB cord-005453-4057qib7 5600 7 separated separate VBN cord-005453-4057qib7 5600 8 from from IN cord-005453-4057qib7 5600 9 from from IN cord-005453-4057qib7 5600 10 toxicity toxicity NN cord-005453-4057qib7 5600 11 to to IN cord-005453-4057qib7 5600 12 infectious infectious JJ cord-005453-4057qib7 5600 13 complications complication NNS cord-005453-4057qib7 5600 14 in in IN cord-005453-4057qib7 5600 15 the the DT cord-005453-4057qib7 5600 16 early early JJ cord-005453-4057qib7 5600 17 phase phase NN cord-005453-4057qib7 5600 18 after after IN cord-005453-4057qib7 5600 19 alloHSCT alloHSCT NNP cord-005453-4057qib7 5600 20 . . . cord-005453-4057qib7 5601 1 Methods method NNS cord-005453-4057qib7 5601 2 : : : cord-005453-4057qib7 5601 3 From from IN cord-005453-4057qib7 5601 4 our -PRON- PRP$ cord-005453-4057qib7 5601 5 files file NNS cord-005453-4057qib7 5601 6 we -PRON- PRP cord-005453-4057qib7 5601 7 identified identify VBD cord-005453-4057qib7 5601 8 65 65 CD cord-005453-4057qib7 5601 9 patients patient NNS cord-005453-4057qib7 5601 10 which which WDT cord-005453-4057qib7 5601 11 had have VBD cord-005453-4057qib7 5601 12 upper upper JJ cord-005453-4057qib7 5601 13 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 5601 14 tract tract NN cord-005453-4057qib7 5601 15 endoscopy endoscopy NN cord-005453-4057qib7 5601 16 after after IN cord-005453-4057qib7 5601 17 alloHSCT alloHSCT NNP cord-005453-4057qib7 5601 18 in in RP cord-005453-4057qib7 5601 19 with with IN cord-005453-4057qib7 5601 20 biopsies biopsy NNS cord-005453-4057qib7 5601 21 were be VBD cord-005453-4057qib7 5601 22 taken take VBN cord-005453-4057qib7 5601 23 from from IN cord-005453-4057qib7 5601 24 the the DT cord-005453-4057qib7 5601 25 esophagus esophagus NN cord-005453-4057qib7 5601 26 , , , cord-005453-4057qib7 5601 27 stomach stomach NN cord-005453-4057qib7 5601 28 and and CC cord-005453-4057qib7 5601 29 duodenum duodenum NN cord-005453-4057qib7 5601 30 simultaneously simultaneously RB cord-005453-4057qib7 5601 31 . . . cord-005453-4057qib7 5602 1 Of of IN cord-005453-4057qib7 5602 2 these these DT cord-005453-4057qib7 5602 3 patients patient NNS cord-005453-4057qib7 5602 4 14 14 CD cord-005453-4057qib7 5602 5 were be VBD cord-005453-4057qib7 5602 6 excluded exclude VBN cord-005453-4057qib7 5602 7 because because IN cord-005453-4057qib7 5602 8 of of IN cord-005453-4057qib7 5602 9 infection infection NN cord-005453-4057qib7 5602 10 , , , cord-005453-4057qib7 5602 11 reflux reflux NN cord-005453-4057qib7 5602 12 disease disease NN cord-005453-4057qib7 5602 13 or or CC cord-005453-4057qib7 5602 14 drug drug NN cord-005453-4057qib7 5602 15 toxity toxity NN cord-005453-4057qib7 5602 16 and and CC cord-005453-4057qib7 5602 17 the the DT cord-005453-4057qib7 5602 18 remaining remain VBG cord-005453-4057qib7 5602 19 51 51 CD cord-005453-4057qib7 5602 20 patients patient NNS cord-005453-4057qib7 5602 21 were be VBD cord-005453-4057qib7 5602 22 included include VBN cord-005453-4057qib7 5602 23 in in IN cord-005453-4057qib7 5602 24 our -PRON- PRP$ cord-005453-4057qib7 5602 25 study study NN cord-005453-4057qib7 5602 26 . . . cord-005453-4057qib7 5603 1 We -PRON- PRP cord-005453-4057qib7 5603 2 evaluated evaluate VBD cord-005453-4057qib7 5603 3 the the DT cord-005453-4057qib7 5603 4 routine routine JJ cord-005453-4057qib7 5603 5 stained stain VBN cord-005453-4057qib7 5603 6 esophageal esophageal JJ cord-005453-4057qib7 5603 7 biopsies biopsy NNS cord-005453-4057qib7 5603 8 , , , cord-005453-4057qib7 5603 9 applied apply VBD cord-005453-4057qib7 5603 10 a a DT cord-005453-4057qib7 5603 11 grading grading NN cord-005453-4057qib7 5603 12 scheme scheme NN cord-005453-4057qib7 5603 13 and and CC cord-005453-4057qib7 5603 14 compared compare VBD cord-005453-4057qib7 5603 15 the the DT cord-005453-4057qib7 5603 16 histological histological JJ cord-005453-4057qib7 5603 17 findings finding NNS cord-005453-4057qib7 5603 18 with with IN cord-005453-4057qib7 5603 19 those those DT cord-005453-4057qib7 5603 20 within within IN cord-005453-4057qib7 5603 21 the the DT cord-005453-4057qib7 5603 22 stomach stomach NN cord-005453-4057qib7 5603 23 and and CC cord-005453-4057qib7 5603 24 duodenum duodenum NN cord-005453-4057qib7 5603 25 , , , cord-005453-4057qib7 5603 26 the the DT cord-005453-4057qib7 5603 27 endoscopic endoscopic JJ cord-005453-4057qib7 5603 28 findings finding NNS cord-005453-4057qib7 5603 29 and and CC cord-005453-4057qib7 5603 30 the the DT cord-005453-4057qib7 5603 31 clinical clinical JJ cord-005453-4057qib7 5603 32 course course NN cord-005453-4057qib7 5603 33 . . . cord-005453-4057qib7 5604 1 Results result NNS cord-005453-4057qib7 5604 2 : : : cord-005453-4057qib7 5605 1 In in IN cord-005453-4057qib7 5605 2 32 32 CD cord-005453-4057qib7 5605 3 of of IN cord-005453-4057qib7 5605 4 51 51 CD cord-005453-4057qib7 5605 5 biopsy biopsy NN cord-005453-4057qib7 5605 6 samples sample NNS cord-005453-4057qib7 5605 7 of of IN cord-005453-4057qib7 5605 8 the the DT cord-005453-4057qib7 5605 9 esophagus esophagus NN cord-005453-4057qib7 5605 10 , , , cord-005453-4057qib7 5605 11 we -PRON- PRP cord-005453-4057qib7 5605 12 identified identify VBD cord-005453-4057qib7 5605 13 histological histological JJ cord-005453-4057qib7 5605 14 features feature NNS cord-005453-4057qib7 5605 15 of of IN cord-005453-4057qib7 5605 16 acute acute JJ cord-005453-4057qib7 5605 17 GvHD gvhd NN cord-005453-4057qib7 5605 18 , , , cord-005453-4057qib7 5605 19 ranging range VBG cord-005453-4057qib7 5605 20 from from IN cord-005453-4057qib7 5605 21 vacuolar vacuolar NNP cord-005453-4057qib7 5605 22 degeneration degeneration NN cord-005453-4057qib7 5605 23 ( ( -LRB- cord-005453-4057qib7 5605 24 grade grade NN cord-005453-4057qib7 5605 25 1 1 CD cord-005453-4057qib7 5605 26 ) ) -RRB- cord-005453-4057qib7 5605 27 and and CC cord-005453-4057qib7 5605 28 single single JJ cord-005453-4057qib7 5605 29 - - HYPH cord-005453-4057qib7 5605 30 cell cell NN cord-005453-4057qib7 5605 31 apoptosis apoptosis NN cord-005453-4057qib7 5605 32 ( ( -LRB- cord-005453-4057qib7 5605 33 grade grade NN cord-005453-4057qib7 5605 34 2 2 CD cord-005453-4057qib7 5605 35 ) ) -RRB- cord-005453-4057qib7 5605 36 to to IN cord-005453-4057qib7 5605 37 the the DT cord-005453-4057qib7 5605 38 formation formation NN cord-005453-4057qib7 5605 39 of of IN cord-005453-4057qib7 5605 40 clefts cleft NNS cord-005453-4057qib7 5605 41 ( ( -LRB- cord-005453-4057qib7 5605 42 grade grade NN cord-005453-4057qib7 5605 43 3 3 CD cord-005453-4057qib7 5605 44 ) ) -RRB- cord-005453-4057qib7 5605 45 and and CC cord-005453-4057qib7 5605 46 mucosa mucosa JJ cord-005453-4057qib7 5605 47 denudation denudation NN cord-005453-4057qib7 5605 48 in in IN cord-005453-4057qib7 5605 49 advanced advanced JJ cord-005453-4057qib7 5605 50 cases case NNS cord-005453-4057qib7 5605 51 ( ( -LRB- cord-005453-4057qib7 5605 52 grade grade NN cord-005453-4057qib7 5605 53 4 4 CD cord-005453-4057qib7 5605 54 ) ) -RRB- cord-005453-4057qib7 5605 55 , , , cord-005453-4057qib7 5605 56 resembling resemble VBG cord-005453-4057qib7 5605 57 epithelial epithelial JJ cord-005453-4057qib7 5605 58 lesions lesion NNS cord-005453-4057qib7 5605 59 in in IN cord-005453-4057qib7 5605 60 acute acute JJ cord-005453-4057qib7 5605 61 GvHD gvhd NN cord-005453-4057qib7 5605 62 of of IN cord-005453-4057qib7 5605 63 the the DT cord-005453-4057qib7 5605 64 skin skin NN cord-005453-4057qib7 5605 65 . . . cord-005453-4057qib7 5606 1 These these DT cord-005453-4057qib7 5606 2 findings finding NNS cord-005453-4057qib7 5606 3 correlated correlate VBD cord-005453-4057qib7 5606 4 with with IN cord-005453-4057qib7 5606 5 GvHD gvhd NN cord-005453-4057qib7 5606 6 involving involve VBG cord-005453-4057qib7 5606 7 the the DT cord-005453-4057qib7 5606 8 stomach stomach NN cord-005453-4057qib7 5606 9 and and CC cord-005453-4057qib7 5606 10 duodenum duodenum NN cord-005453-4057qib7 5606 11 and and CC cord-005453-4057qib7 5606 12 the the DT cord-005453-4057qib7 5606 13 clinical clinical JJ cord-005453-4057qib7 5606 14 manifestations manifestation NNS cord-005453-4057qib7 5606 15 of of IN cord-005453-4057qib7 5606 16 GvHD GvHD NNP cord-005453-4057qib7 5606 17 in in IN cord-005453-4057qib7 5606 18 other other JJ cord-005453-4057qib7 5606 19 organs organ NNS cord-005453-4057qib7 5606 20 . . . cord-005453-4057qib7 5607 1 Endoscopically endoscopically RB cord-005453-4057qib7 5607 2 patients patient NNS cord-005453-4057qib7 5607 3 with with IN cord-005453-4057qib7 5607 4 GvHD GvHD NNP cord-005453-4057qib7 5607 5 revealed reveal VBD cord-005453-4057qib7 5607 6 signs sign NNS cord-005453-4057qib7 5607 7 of of IN cord-005453-4057qib7 5607 8 inflammation inflammation NN cord-005453-4057qib7 5607 9 , , , cord-005453-4057qib7 5607 10 ranging range VBG cord-005453-4057qib7 5607 11 from from IN cord-005453-4057qib7 5607 12 erythema erythema NN cord-005453-4057qib7 5607 13 to to IN cord-005453-4057qib7 5607 14 ulceration ulceration NN cord-005453-4057qib7 5607 15 in in IN cord-005453-4057qib7 5607 16 the the DT cord-005453-4057qib7 5607 17 more more RBR cord-005453-4057qib7 5607 18 advanced advanced JJ cord-005453-4057qib7 5607 19 cases case NNS cord-005453-4057qib7 5607 20 , , , cord-005453-4057qib7 5607 21 sometimes sometimes RB cord-005453-4057qib7 5607 22 reminiscent reminiscent JJ cord-005453-4057qib7 5607 23 of of IN cord-005453-4057qib7 5607 24 reflux reflux NN cord-005453-4057qib7 5607 25 or or CC cord-005453-4057qib7 5607 26 infection infection NN cord-005453-4057qib7 5607 27 . . . cord-005453-4057qib7 5608 1 Clinically clinically RB cord-005453-4057qib7 5608 2 these these DT cord-005453-4057qib7 5608 3 patients patient NNS cord-005453-4057qib7 5608 4 had have VBD cord-005453-4057qib7 5608 5 abdominal abdominal JJ cord-005453-4057qib7 5608 6 discomfort discomfort NN cord-005453-4057qib7 5608 7 ranging range VBG cord-005453-4057qib7 5608 8 from from IN cord-005453-4057qib7 5608 9 inappetence inappetence NN cord-005453-4057qib7 5608 10 to to IN cord-005453-4057qib7 5608 11 nausea nausea NN cord-005453-4057qib7 5608 12 , , , cord-005453-4057qib7 5608 13 accompanied accompany VBN cord-005453-4057qib7 5608 14 by by IN cord-005453-4057qib7 5608 15 emesis emesis NN cord-005453-4057qib7 5608 16 or or CC cord-005453-4057qib7 5608 17 diarrhea diarrhea NN cord-005453-4057qib7 5608 18 and and CC cord-005453-4057qib7 5608 19 weight weight NN cord-005453-4057qib7 5608 20 loss loss NN cord-005453-4057qib7 5608 21 . . . cord-005453-4057qib7 5609 1 Conclusions conclusion NNS cord-005453-4057qib7 5609 2 : : : cord-005453-4057qib7 5610 1 We -PRON- PRP cord-005453-4057qib7 5610 2 have have VBP cord-005453-4057qib7 5610 3 shown show VBN cord-005453-4057qib7 5610 4 that that IN cord-005453-4057qib7 5610 5 acute acute JJ cord-005453-4057qib7 5610 6 esophageal esophageal JJ cord-005453-4057qib7 5610 7 GvHD gvhd NN cord-005453-4057qib7 5610 8 occurs occur VBZ cord-005453-4057qib7 5610 9 after after IN cord-005453-4057qib7 5610 10 alloHSCT alloHSCT NNP cord-005453-4057qib7 5610 11 and and CC cord-005453-4057qib7 5610 12 is be VBZ cord-005453-4057qib7 5610 13 correlated correlate VBN cord-005453-4057qib7 5610 14 with with IN cord-005453-4057qib7 5610 15 acute acute JJ cord-005453-4057qib7 5610 16 GvHD gvhd NN cord-005453-4057qib7 5610 17 in in IN cord-005453-4057qib7 5610 18 stomach stomach NN cord-005453-4057qib7 5610 19 and and CC cord-005453-4057qib7 5610 20 duodenum duodenum NN cord-005453-4057qib7 5610 21 . . . cord-005453-4057qib7 5611 1 It -PRON- PRP cord-005453-4057qib7 5611 2 could could MD cord-005453-4057qib7 5611 3 be be VB cord-005453-4057qib7 5611 4 diagnosed diagnose VBN cord-005453-4057qib7 5611 5 and and CC cord-005453-4057qib7 5611 6 graded grade VBN cord-005453-4057qib7 5611 7 histologically histologically RB cord-005453-4057qib7 5611 8 . . . cord-005453-4057qib7 5612 1 The the DT cord-005453-4057qib7 5612 2 endoscopic endoscopic JJ cord-005453-4057qib7 5612 3 findings finding NNS cord-005453-4057qib7 5612 4 are be VBP cord-005453-4057qib7 5612 5 signs sign NNS cord-005453-4057qib7 5612 6 of of IN cord-005453-4057qib7 5612 7 inflammation inflammation NN cord-005453-4057qib7 5612 8 . . . cord-005453-4057qib7 5613 1 Our -PRON- PRP$ cord-005453-4057qib7 5613 2 results result NNS cord-005453-4057qib7 5613 3 may may MD cord-005453-4057qib7 5613 4 help help VB cord-005453-4057qib7 5613 5 to to TO cord-005453-4057qib7 5613 6 establish establish VB cord-005453-4057qib7 5613 7 the the DT cord-005453-4057qib7 5613 8 histological histological JJ cord-005453-4057qib7 5613 9 diagnosis diagnosis NN cord-005453-4057qib7 5613 10 of of IN cord-005453-4057qib7 5613 11 acute acute JJ cord-005453-4057qib7 5613 12 GvHD gvhd NN cord-005453-4057qib7 5613 13 using use VBG cord-005453-4057qib7 5613 14 endoscopic endoscopic JJ cord-005453-4057qib7 5613 15 biopsies biopsy NNS cord-005453-4057qib7 5613 16 from from IN cord-005453-4057qib7 5613 17 the the DT cord-005453-4057qib7 5613 18 esophagus esophagus NN cord-005453-4057qib7 5613 19 and and CC cord-005453-4057qib7 5613 20 to to TO cord-005453-4057qib7 5613 21 explain explain VB cord-005453-4057qib7 5613 22 the the DT cord-005453-4057qib7 5613 23 alterations alteration NNS cord-005453-4057qib7 5613 24 observed observe VBN cord-005453-4057qib7 5613 25 in in IN cord-005453-4057qib7 5613 26 the the DT cord-005453-4057qib7 5613 27 esophageal esophageal JJ cord-005453-4057qib7 5613 28 mucosa mucosa NN cord-005453-4057qib7 5613 29 in in IN cord-005453-4057qib7 5613 30 patients patient NNS cord-005453-4057qib7 5613 31 after after IN cord-005453-4057qib7 5613 32 alloHSCT alloHSCT NNP cord-005453-4057qib7 5613 33 . . . cord-005453-4057qib7 5614 1 [ [ -LRB- cord-005453-4057qib7 5614 2 Background background NN cord-005453-4057qib7 5614 3 : : : cord-005453-4057qib7 5614 4 Intestinal intestinal JJ cord-005453-4057qib7 5614 5 acute acute JJ cord-005453-4057qib7 5614 6 graft graft NN cord-005453-4057qib7 5614 7 versus versus IN cord-005453-4057qib7 5614 8 host host NN cord-005453-4057qib7 5614 9 disease disease NN cord-005453-4057qib7 5614 10 ( ( -LRB- cord-005453-4057qib7 5614 11 aGvHD agvhd NN cord-005453-4057qib7 5614 12 ) ) -RRB- cord-005453-4057qib7 5614 13 is be VBZ cord-005453-4057qib7 5614 14 a a DT cord-005453-4057qib7 5614 15 major major JJ cord-005453-4057qib7 5614 16 thread thread NN cord-005453-4057qib7 5614 17 after after IN cord-005453-4057qib7 5614 18 allogenic allogenic JJ cord-005453-4057qib7 5614 19 hematological hematological JJ cord-005453-4057qib7 5614 20 stem stem NN cord-005453-4057qib7 5614 21 cell cell NN cord-005453-4057qib7 5614 22 transplantation transplantation NN cord-005453-4057qib7 5614 23 ( ( -LRB- cord-005453-4057qib7 5614 24 alloHSCT alloHSCT NNP cord-005453-4057qib7 5614 25 ) ) -RRB- cord-005453-4057qib7 5614 26 , , , cord-005453-4057qib7 5614 27 with with IN cord-005453-4057qib7 5614 28 a a DT cord-005453-4057qib7 5614 29 high high JJ cord-005453-4057qib7 5614 30 mortality mortality NN cord-005453-4057qib7 5614 31 in in IN cord-005453-4057qib7 5614 32 patients patient NNS cord-005453-4057qib7 5614 33 which which WDT cord-005453-4057qib7 5614 34 were be VBD cord-005453-4057qib7 5614 35 refractory refractory JJ cord-005453-4057qib7 5614 36 to to IN cord-005453-4057qib7 5614 37 steroid steroid NN cord-005453-4057qib7 5614 38 treatment treatment NN cord-005453-4057qib7 5614 39 in in IN cord-005453-4057qib7 5614 40 particular particular JJ cord-005453-4057qib7 5614 41 . . . cord-005453-4057qib7 5615 1 Recent recent JJ cord-005453-4057qib7 5615 2 papers paper NNS cord-005453-4057qib7 5615 3 point point VBP cord-005453-4057qib7 5615 4 to to IN cord-005453-4057qib7 5615 5 a a DT cord-005453-4057qib7 5615 6 correlation correlation NN cord-005453-4057qib7 5615 7 of of IN cord-005453-4057qib7 5615 8 histological histological JJ cord-005453-4057qib7 5615 9 grading grading NN cord-005453-4057qib7 5615 10 of of IN cord-005453-4057qib7 5615 11 intestinal intestinal JJ cord-005453-4057qib7 5615 12 GvHD gvhd NN cord-005453-4057qib7 5615 13 and and CC cord-005453-4057qib7 5615 14 prognosis prognosis NN cord-005453-4057qib7 5615 15 in in IN cord-005453-4057qib7 5615 16 patient patient NN cord-005453-4057qib7 5615 17 after after IN cord-005453-4057qib7 5615 18 alloHSCT alloHSCT NNP cord-005453-4057qib7 5615 19 . . . cord-005453-4057qib7 5616 1 However however RB cord-005453-4057qib7 5616 2 a a DT cord-005453-4057qib7 5616 3 comparison comparison NN cord-005453-4057qib7 5616 4 with with IN cord-005453-4057qib7 5616 5 clinical clinical JJ cord-005453-4057qib7 5616 6 scores score NNS cord-005453-4057qib7 5616 7 has have VBZ cord-005453-4057qib7 5616 8 not not RB cord-005453-4057qib7 5616 9 been be VBN cord-005453-4057qib7 5616 10 performed perform VBN cord-005453-4057qib7 5616 11 so so RB cord-005453-4057qib7 5616 12 far far RB cord-005453-4057qib7 5616 13 . . . cord-005453-4057qib7 5617 1 Methods method NNS cord-005453-4057qib7 5617 2 : : : cord-005453-4057qib7 5617 3 In in IN cord-005453-4057qib7 5617 4 this this DT cord-005453-4057qib7 5617 5 analysis analysis NN cord-005453-4057qib7 5617 6 , , , cord-005453-4057qib7 5617 7 retrospective retrospective JJ cord-005453-4057qib7 5617 8 data datum NNS cord-005453-4057qib7 5617 9 from from IN cord-005453-4057qib7 5617 10 89 89 CD cord-005453-4057qib7 5617 11 patients patient NNS cord-005453-4057qib7 5617 12 who who WP cord-005453-4057qib7 5617 13 underwent undergo VBD cord-005453-4057qib7 5617 14 endoscopy endoscopy NN cord-005453-4057qib7 5617 15 due due IN cord-005453-4057qib7 5617 16 to to IN cord-005453-4057qib7 5617 17 clinical clinical JJ cord-005453-4057qib7 5617 18 signs sign NNS cord-005453-4057qib7 5617 19 of of IN cord-005453-4057qib7 5617 20 aGVHD aGVHD NNP cord-005453-4057qib7 5617 21 ( ( -LRB- cord-005453-4057qib7 5617 22 day day NN cord-005453-4057qib7 5617 23 +20 +20 CD cord-005453-4057qib7 5617 24 to to IN cord-005453-4057qib7 5617 25 +200 +200 NNP cord-005453-4057qib7 5617 26 after after IN cord-005453-4057qib7 5617 27 alloHSCT alloHSCT NNP cord-005453-4057qib7 5617 28 ) ) -RRB- cord-005453-4057qib7 5617 29 were be VBD cord-005453-4057qib7 5617 30 evaluated evaluate VBN cord-005453-4057qib7 5617 31 . . . cord-005453-4057qib7 5618 1 Of of IN cord-005453-4057qib7 5618 2 each each DT cord-005453-4057qib7 5618 3 patient patient NN cord-005453-4057qib7 5618 4 least least JJS cord-005453-4057qib7 5618 5 3 3 CD cord-005453-4057qib7 5618 6 biopsies biopsy NNS cord-005453-4057qib7 5618 7 from from IN cord-005453-4057qib7 5618 8 different different JJ cord-005453-4057qib7 5618 9 sites site NNS cord-005453-4057qib7 5618 10 of of IN cord-005453-4057qib7 5618 11 the the DT cord-005453-4057qib7 5618 12 colon colon NN cord-005453-4057qib7 5618 13 which which WDT cord-005453-4057qib7 5618 14 were be VBD cord-005453-4057qib7 5618 15 taken take VBN cord-005453-4057qib7 5618 16 simultaneously simultaneously RB cord-005453-4057qib7 5618 17 . . . cord-005453-4057qib7 5619 1 Of of IN cord-005453-4057qib7 5619 2 each each DT cord-005453-4057qib7 5619 3 biopsy biopsy NNP cord-005453-4057qib7 5619 4 series series NN cord-005453-4057qib7 5619 5 the the DT cord-005453-4057qib7 5619 6 maximum maximum JJ cord-005453-4057qib7 5619 7 histological histological JJ cord-005453-4057qib7 5619 8 grad grad NN cord-005453-4057qib7 5619 9 of of IN cord-005453-4057qib7 5619 10 aGvHD agvhd NN cord-005453-4057qib7 5619 11 according accord VBG cord-005453-4057qib7 5619 12 to to IN cord-005453-4057qib7 5619 13 the the DT cord-005453-4057qib7 5619 14 Lerner Lerner NNP cord-005453-4057qib7 5619 15 scheme scheme NN cord-005453-4057qib7 5619 16 was be VBD cord-005453-4057qib7 5619 17 obtained obtain VBN cord-005453-4057qib7 5619 18 and and CC cord-005453-4057qib7 5619 19 compared compare VBN cord-005453-4057qib7 5619 20 with with IN cord-005453-4057qib7 5619 21 the the DT cord-005453-4057qib7 5619 22 Glucksberg Glucksberg NNP cord-005453-4057qib7 5619 23 stage stage NN cord-005453-4057qib7 5619 24 of of IN cord-005453-4057qib7 5619 25 the the DT cord-005453-4057qib7 5619 26 lower low JJR cord-005453-4057qib7 5619 27 gastro gastro JJ cord-005453-4057qib7 5619 28 intestinal intestinal JJ cord-005453-4057qib7 5619 29 tract tract NN cord-005453-4057qib7 5619 30 ( ( -LRB- cord-005453-4057qib7 5619 31 GSLGI GSLGI NNP cord-005453-4057qib7 5619 32 ) ) -RRB- cord-005453-4057qib7 5619 33 and and CC cord-005453-4057qib7 5619 34 the the DT cord-005453-4057qib7 5619 35 overall overall JJ cord-005453-4057qib7 5619 36 Glucksberg Glucksberg NNP cord-005453-4057qib7 5619 37 grade grade NN cord-005453-4057qib7 5619 38 ( ( -LRB- cord-005453-4057qib7 5619 39 OGG OGG NNP cord-005453-4057qib7 5619 40 ) ) -RRB- cord-005453-4057qib7 5619 41 . . . cord-005453-4057qib7 5620 1 These these DT cord-005453-4057qib7 5620 2 three three CD cord-005453-4057qib7 5620 3 grades grade NNS cord-005453-4057qib7 5620 4 were be VBD cord-005453-4057qib7 5620 5 compared compare VBN cord-005453-4057qib7 5620 6 for for IN cord-005453-4057qib7 5620 7 non non JJ cord-005453-4057qib7 5620 8 - - JJ cord-005453-4057qib7 5620 9 relaps relaps JJ cord-005453-4057qib7 5620 10 related relate VBN cord-005453-4057qib7 5620 11 mortality mortality NN cord-005453-4057qib7 5620 12 using use VBG cord-005453-4057qib7 5620 13 the the DT cord-005453-4057qib7 5620 14 Log Log NNP cord-005453-4057qib7 5620 15 - - HYPH cord-005453-4057qib7 5620 16 Rank Rank NNP cord-005453-4057qib7 5620 17 test test NN cord-005453-4057qib7 5620 18 and and CC cord-005453-4057qib7 5620 19 for for IN cord-005453-4057qib7 5620 20 sensitivity sensitivity NN cord-005453-4057qib7 5620 21 to to IN cord-005453-4057qib7 5620 22 steroid steroid NN cord-005453-4057qib7 5620 23 treatment treatment NN cord-005453-4057qib7 5620 24 applying apply VBG cord-005453-4057qib7 5620 25 the the DT cord-005453-4057qib7 5620 26 Receiver Receiver NNP cord-005453-4057qib7 5620 27 Operating Operating NNP cord-005453-4057qib7 5620 28 Characteristic characteristic NN cord-005453-4057qib7 5620 29 for for IN cord-005453-4057qib7 5620 30 the the DT cord-005453-4057qib7 5620 31 patients patient NNS cord-005453-4057qib7 5620 32 who who WP cord-005453-4057qib7 5620 33 received receive VBD cord-005453-4057qib7 5620 34 steroid steroid JJ cord-005453-4057qib7 5620 35 treatment treatment NN cord-005453-4057qib7 5620 36 . . . cord-005453-4057qib7 5621 1 For for IN cord-005453-4057qib7 5621 2 these these DT cord-005453-4057qib7 5621 3 patients patient NNS cord-005453-4057qib7 5621 4 the the DT cord-005453-4057qib7 5621 5 non non JJ cord-005453-4057qib7 5621 6 - - JJ cord-005453-4057qib7 5621 7 relaps relaps JJ cord-005453-4057qib7 5621 8 related relate VBN cord-005453-4057qib7 5621 9 mortality mortality NN cord-005453-4057qib7 5621 10 for for IN cord-005453-4057qib7 5621 11 responder responder NN cord-005453-4057qib7 5621 12 and and CC cord-005453-4057qib7 5621 13 non non JJ cord-005453-4057qib7 5621 14 - - NN cord-005453-4057qib7 5621 15 responder responder NN cord-005453-4057qib7 5621 16 were be VBD cord-005453-4057qib7 5621 17 calculated calculate VBN cord-005453-4057qib7 5621 18 using use VBG cord-005453-4057qib7 5621 19 also also RB cord-005453-4057qib7 5621 20 Log Log NNP cord-005453-4057qib7 5621 21 - - HYPH cord-005453-4057qib7 5621 22 Rank Rank NNP cord-005453-4057qib7 5621 23 test test NN cord-005453-4057qib7 5621 24 . . . cord-005453-4057qib7 5622 1 Results result NNS cord-005453-4057qib7 5622 2 : : : cord-005453-4057qib7 5623 1 The the DT cord-005453-4057qib7 5623 2 histological histological JJ cord-005453-4057qib7 5623 3 grade grade NN cord-005453-4057qib7 5623 4 strongly strongly RB cord-005453-4057qib7 5623 5 correlated correlate VBD cord-005453-4057qib7 5623 6 with with IN cord-005453-4057qib7 5623 7 the the DT cord-005453-4057qib7 5623 8 survival survival NN cord-005453-4057qib7 5623 9 ( ( -LRB- cord-005453-4057qib7 5623 10 p=0.009 p=0.009 NN cord-005453-4057qib7 5623 11 ) ) -RRB- cord-005453-4057qib7 5623 12 . . . cord-005453-4057qib7 5624 1 A a DT cord-005453-4057qib7 5624 2 statistical statistical JJ cord-005453-4057qib7 5624 3 significant significant JJ cord-005453-4057qib7 5624 4 correlation correlation NN cord-005453-4057qib7 5624 5 was be VBD cord-005453-4057qib7 5624 6 also also RB cord-005453-4057qib7 5624 7 found find VBN cord-005453-4057qib7 5624 8 for for IN cord-005453-4057qib7 5624 9 the the DT cord-005453-4057qib7 5624 10 GSLGI GSLGI NNP cord-005453-4057qib7 5624 11 ( ( -LRB- cord-005453-4057qib7 5624 12 p=0.02 p=0.02 NNP cord-005453-4057qib7 5624 13 ) ) -RRB- cord-005453-4057qib7 5624 14 , , , cord-005453-4057qib7 5624 15 whereas whereas IN cord-005453-4057qib7 5624 16 the the DT cord-005453-4057qib7 5624 17 OGG OGG NNP cord-005453-4057qib7 5624 18 revealed reveal VBD cord-005453-4057qib7 5624 19 no no DT cord-005453-4057qib7 5624 20 significant significant JJ cord-005453-4057qib7 5624 21 correlation correlation NN cord-005453-4057qib7 5624 22 ( ( -LRB- cord-005453-4057qib7 5624 23 p=0.09 p=0.09 NN cord-005453-4057qib7 5624 24 ) ) -RRB- cord-005453-4057qib7 5624 25 . . . cord-005453-4057qib7 5625 1 Non non JJ cord-005453-4057qib7 5625 2 - - NN cord-005453-4057qib7 5625 3 relaps relaps JJ cord-005453-4057qib7 5625 4 related relate VBN cord-005453-4057qib7 5625 5 mortality mortality NN cord-005453-4057qib7 5625 6 was be VBD cord-005453-4057qib7 5625 7 mainly mainly RB cord-005453-4057qib7 5625 8 related relate VBN cord-005453-4057qib7 5625 9 to to IN cord-005453-4057qib7 5625 10 infection infection NN cord-005453-4057qib7 5625 11 or or CC cord-005453-4057qib7 5625 12 sepsis sepsis NN cord-005453-4057qib7 5625 13 ( ( -LRB- cord-005453-4057qib7 5625 14 in in IN cord-005453-4057qib7 5625 15 32/56 32/56 CD cord-005453-4057qib7 5625 16 patients patient NNS cord-005453-4057qib7 5625 17 who who WP cord-005453-4057qib7 5625 18 died die VBD cord-005453-4057qib7 5625 19 ) ) -RRB- cord-005453-4057qib7 5625 20 . . . cord-005453-4057qib7 5626 1 -Eighty -Eighty : cord-005453-4057qib7 5626 2 - - : cord-005453-4057qib7 5626 3 one one CD cord-005453-4057qib7 5626 4 of of IN cord-005453-4057qib7 5626 5 the the DT cord-005453-4057qib7 5626 6 patients patient NNS cord-005453-4057qib7 5626 7 received receive VBD cord-005453-4057qib7 5626 8 steroid steroid NN cord-005453-4057qib7 5626 9 therapy therapy NN cord-005453-4057qib7 5626 10 . . . cord-005453-4057qib7 5627 1 The the DT cord-005453-4057qib7 5627 2 sensitivity sensitivity NN cord-005453-4057qib7 5627 3 to to IN cord-005453-4057qib7 5627 4 the the DT cord-005453-4057qib7 5627 5 steroid steroid NN cord-005453-4057qib7 5627 6 therapy therapy NN cord-005453-4057qib7 5627 7 correlated correlate VBN cord-005453-4057qib7 5627 8 with with IN cord-005453-4057qib7 5627 9 each each DT cord-005453-4057qib7 5627 10 of of IN cord-005453-4057qib7 5627 11 the the DT cord-005453-4057qib7 5627 12 three three CD cord-005453-4057qib7 5627 13 scores score NNS cord-005453-4057qib7 5627 14 ( ( -LRB- cord-005453-4057qib7 5627 15 p p NN cord-005453-4057qib7 5627 16 < < XX cord-005453-4057qib7 5627 17 0.0001 0.0001 CD cord-005453-4057qib7 5627 18 ) ) -RRB- cord-005453-4057qib7 5627 19 but but CC cord-005453-4057qib7 5627 20 was be VBD cord-005453-4057qib7 5627 21 the the DT cord-005453-4057qib7 5627 22 strongest strong JJS cord-005453-4057qib7 5627 23 for for IN cord-005453-4057qib7 5627 24 GSLGI GSLGI NNP cord-005453-4057qib7 5628 1 ( ( -LRB- cord-005453-4057qib7 5628 2 Area area NN cord-005453-4057qib7 5628 3 under under IN cord-005453-4057qib7 5628 4 the the DT cord-005453-4057qib7 5628 5 curve curve NN cord-005453-4057qib7 5628 6 ( ( -LRB- cord-005453-4057qib7 5628 7 AUC AUC NNP cord-005453-4057qib7 5628 8 ) ) -RRB- cord-005453-4057qib7 5628 9 0.829 0.829 CD cord-005453-4057qib7 5628 10 ) ) -RRB- cord-005453-4057qib7 5628 11 , , , cord-005453-4057qib7 5628 12 compared compare VBN cord-005453-4057qib7 5628 13 to to IN cord-005453-4057qib7 5628 14 OGG OGG NNP cord-005453-4057qib7 5628 15 ( ( -LRB- cord-005453-4057qib7 5628 16 AUC AUC NNP cord-005453-4057qib7 5628 17 0.795 0.795 CD cord-005453-4057qib7 5628 18 ) ) -RRB- cord-005453-4057qib7 5628 19 and and CC cord-005453-4057qib7 5628 20 the the DT cord-005453-4057qib7 5628 21 histological histological JJ cord-005453-4057qib7 5628 22 score score NN cord-005453-4057qib7 5628 23 ( ( -LRB- cord-005453-4057qib7 5628 24 AUC AUC NNP cord-005453-4057qib7 5628 25 0.691 0.691 CD cord-005453-4057qib7 5628 26 ) ) -RRB- cord-005453-4057qib7 5628 27 . . . cord-005453-4057qib7 5629 1 The the DT cord-005453-4057qib7 5629 2 survival survival NN cord-005453-4057qib7 5629 3 of of IN cord-005453-4057qib7 5629 4 the the DT cord-005453-4057qib7 5629 5 patients patient NNS cord-005453-4057qib7 5629 6 , , , cord-005453-4057qib7 5629 7 which which WDT cord-005453-4057qib7 5629 8 were be VBD cord-005453-4057qib7 5629 9 sensitive sensitive JJ cord-005453-4057qib7 5629 10 to to IN cord-005453-4057qib7 5629 11 steroid steroid NN cord-005453-4057qib7 5629 12 treatment treatment NN cord-005453-4057qib7 5629 13 was be VBD cord-005453-4057qib7 5629 14 significantly significantly RB cord-005453-4057qib7 5629 15 better well JJR cord-005453-4057qib7 5629 16 than than IN cord-005453-4057qib7 5629 17 those those DT cord-005453-4057qib7 5629 18 of of IN cord-005453-4057qib7 5629 19 steroid steroid NN cord-005453-4057qib7 5629 20 refractory refractory JJ cord-005453-4057qib7 5629 21 patients patient NNS cord-005453-4057qib7 5629 22 ( ( -LRB- cord-005453-4057qib7 5629 23 p=0.005 p=0.005 NNP cord-005453-4057qib7 5629 24 ) ) -RRB- cord-005453-4057qib7 5629 25 . . . cord-005453-4057qib7 5630 1 Conclusions conclusion NNS cord-005453-4057qib7 5630 2 : : : cord-005453-4057qib7 5631 1 We -PRON- PRP cord-005453-4057qib7 5631 2 found find VBD cord-005453-4057qib7 5631 3 that that IN cord-005453-4057qib7 5631 4 histological histological JJ cord-005453-4057qib7 5631 5 and and CC cord-005453-4057qib7 5631 6 clinical clinical JJ cord-005453-4057qib7 5631 7 grading grading NN cord-005453-4057qib7 5631 8 in in IN cord-005453-4057qib7 5631 9 patients patient NNS cord-005453-4057qib7 5631 10 after after IN cord-005453-4057qib7 5631 11 alloHSCT alloHSCT NNP cord-005453-4057qib7 5631 12 with with IN cord-005453-4057qib7 5631 13 intestinal intestinal JJ cord-005453-4057qib7 5631 14 GvHD GvHD NNP cord-005453-4057qib7 5631 15 was be VBD cord-005453-4057qib7 5631 16 correlated correlate VBN cord-005453-4057qib7 5631 17 with with IN cord-005453-4057qib7 5631 18 survival survival NN cord-005453-4057qib7 5631 19 and and CC cord-005453-4057qib7 5631 20 respond respond VB cord-005453-4057qib7 5631 21 to to IN cord-005453-4057qib7 5631 22 steroid steroid NN cord-005453-4057qib7 5631 23 treatment treatment NN cord-005453-4057qib7 5631 24 . . . cord-005453-4057qib7 5632 1 Histological Histological NNP cord-005453-4057qib7 5632 2 scoring scoring NN cord-005453-4057qib7 5632 3 may may MD cord-005453-4057qib7 5632 4 predict predict VB cord-005453-4057qib7 5632 5 survival survival NN cord-005453-4057qib7 5632 6 more more RBR cord-005453-4057qib7 5632 7 precisely precisely RB cord-005453-4057qib7 5632 8 than than IN cord-005453-4057qib7 5632 9 OGG ogg NN cord-005453-4057qib7 5632 10 and and CC cord-005453-4057qib7 5632 11 GSLGI GSLGI NNP cord-005453-4057qib7 5632 12 but but CC cord-005453-4057qib7 5632 13 did do VBD cord-005453-4057qib7 5632 14 not not RB cord-005453-4057qib7 5632 15 add add VB cord-005453-4057qib7 5632 16 substantial substantial JJ cord-005453-4057qib7 5632 17 information information NN cord-005453-4057qib7 5632 18 to to IN cord-005453-4057qib7 5632 19 the the DT cord-005453-4057qib7 5632 20 prediction prediction NN cord-005453-4057qib7 5632 21 of of IN cord-005453-4057qib7 5632 22 treatment treatment NN cord-005453-4057qib7 5632 23 response response NN cord-005453-4057qib7 5632 24 . . . cord-005453-4057qib7 5633 1 [ [ -LRB- cord-005453-4057qib7 5633 2 Emerging emerge VBG cord-005453-4057qib7 5633 3 evidences evidence NNS cord-005453-4057qib7 5633 4 suggest suggest VBP cord-005453-4057qib7 5633 5 that that IN cord-005453-4057qib7 5633 6 regulatory regulatory JJ cord-005453-4057qib7 5633 7 B b NN cord-005453-4057qib7 5633 8 cells cell NNS cord-005453-4057qib7 5633 9 ( ( -LRB- cord-005453-4057qib7 5633 10 Bregs Bregs NNP cord-005453-4057qib7 5633 11 ) ) -RRB- cord-005453-4057qib7 5633 12 play play VB cord-005453-4057qib7 5633 13 essential essential JJ cord-005453-4057qib7 5633 14 roles role NNS cord-005453-4057qib7 5633 15 in in IN cord-005453-4057qib7 5633 16 inflammation inflammation NN cord-005453-4057qib7 5633 17 , , , cord-005453-4057qib7 5633 18 autoimmune autoimmune JJ cord-005453-4057qib7 5633 19 diseases disease NNS cord-005453-4057qib7 5633 20 and and CC cord-005453-4057qib7 5633 21 tumors tumor NNS cord-005453-4057qib7 5633 22 . . . cord-005453-4057qib7 5634 1 Few few JJ cord-005453-4057qib7 5634 2 data datum NNS cord-005453-4057qib7 5634 3 exist exist VBP cord-005453-4057qib7 5634 4 about about IN cord-005453-4057qib7 5634 5 the the DT cord-005453-4057qib7 5634 6 role role NN cord-005453-4057qib7 5634 7 of of IN cord-005453-4057qib7 5634 8 Bregs Bregs NNP cord-005453-4057qib7 5634 9 in in IN cord-005453-4057qib7 5634 10 the the DT cord-005453-4057qib7 5634 11 contest contest NN cord-005453-4057qib7 5634 12 of of IN cord-005453-4057qib7 5634 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 5634 14 allogeneic allogeneic NN cord-005453-4057qib7 5634 15 stem stem NN cord-005453-4057qib7 5634 16 cell cell NN cord-005453-4057qib7 5634 17 transplantation transplantation NN cord-005453-4057qib7 5634 18 ( ( -LRB- cord-005453-4057qib7 5634 19 HSCT HSCT NNP cord-005453-4057qib7 5634 20 ) ) -RRB- cord-005453-4057qib7 5634 21 . . . cord-005453-4057qib7 5635 1 Some some DT cord-005453-4057qib7 5635 2 authors author NNS cord-005453-4057qib7 5635 3 have have VBP cord-005453-4057qib7 5635 4 observed observe VBN cord-005453-4057qib7 5635 5 that that IN cord-005453-4057qib7 5635 6 Bregs Bregs NNP cord-005453-4057qib7 5635 7 from from IN cord-005453-4057qib7 5635 8 patients patient NNS cord-005453-4057qib7 5635 9 with with IN cord-005453-4057qib7 5635 10 chronic chronic JJ cord-005453-4057qib7 5635 11 graft graft NN cord-005453-4057qib7 5635 12 - - HYPH cord-005453-4057qib7 5635 13 versus versus IN cord-005453-4057qib7 5635 14 - - HYPH cord-005453-4057qib7 5635 15 host host NN cord-005453-4057qib7 5635 16 disease disease NN cord-005453-4057qib7 5635 17 ( ( -LRB- cord-005453-4057qib7 5635 18 cGVHD cGVHD NNP cord-005453-4057qib7 5635 19 ) ) -RRB- cord-005453-4057qib7 5635 20 were be VBD cord-005453-4057qib7 5635 21 less less RBR cord-005453-4057qib7 5635 22 frequent frequent JJ cord-005453-4057qib7 5635 23 and and CC cord-005453-4057qib7 5635 24 less less RBR cord-005453-4057qib7 5635 25 likely likely JJ cord-005453-4057qib7 5635 26 to to TO cord-005453-4057qib7 5635 27 produce produce VB cord-005453-4057qib7 5636 1 IL-10 IL-10 NNP cord-005453-4057qib7 5636 2 than than IN cord-005453-4057qib7 5636 3 Bregs Bregs NNP cord-005453-4057qib7 5636 4 as as IN cord-005453-4057qib7 5636 5 compared compare VBN cord-005453-4057qib7 5636 6 to to IN cord-005453-4057qib7 5636 7 healthy healthy JJ cord-005453-4057qib7 5636 8 donors donor NNS cord-005453-4057qib7 5636 9 or or CC cord-005453-4057qib7 5636 10 patients patient NNS cord-005453-4057qib7 5636 11 without without IN cord-005453-4057qib7 5636 12 cGVHD cGVHD NNP cord-005453-4057qib7 5636 13 . . . cord-005453-4057qib7 5637 1 These these DT cord-005453-4057qib7 5637 2 findings finding NNS cord-005453-4057qib7 5637 3 suggest suggest VBP cord-005453-4057qib7 5637 4 that that IN cord-005453-4057qib7 5637 5 Bregs Bregs NNP cord-005453-4057qib7 5637 6 may may MD cord-005453-4057qib7 5637 7 be be VB cord-005453-4057qib7 5637 8 involved involve VBN cord-005453-4057qib7 5637 9 in in IN cord-005453-4057qib7 5637 10 cGVHD cGVHD NNP cord-005453-4057qib7 5637 11 pathogenesis pathogenesis NN cord-005453-4057qib7 5637 12 . . . cord-005453-4057qib7 5638 1 The the DT cord-005453-4057qib7 5638 2 purpose purpose NN cord-005453-4057qib7 5638 3 of of IN cord-005453-4057qib7 5638 4 our -PRON- PRP$ cord-005453-4057qib7 5638 5 study study NN cord-005453-4057qib7 5638 6 was be VBD cord-005453-4057qib7 5638 7 to to TO cord-005453-4057qib7 5638 8 evaluate evaluate VB cord-005453-4057qib7 5638 9 a a DT cord-005453-4057qib7 5638 10 possible possible JJ cord-005453-4057qib7 5638 11 role role NN cord-005453-4057qib7 5638 12 of of IN cord-005453-4057qib7 5638 13 B b NN cord-005453-4057qib7 5638 14 cell cell NN cord-005453-4057qib7 5638 15 subsets subset NNS cord-005453-4057qib7 5638 16 on on IN cord-005453-4057qib7 5638 17 GVHD GVHD NNP cord-005453-4057qib7 5638 18 occurrence occurrence NN cord-005453-4057qib7 5638 19 . . . cord-005453-4057qib7 5639 1 Methods method NNS cord-005453-4057qib7 5639 2 : : : cord-005453-4057qib7 5639 3 Lymphocyte lymphocyte NN cord-005453-4057qib7 5639 4 subset subset JJ cord-005453-4057qib7 5639 5 enumeration enumeration NN cord-005453-4057qib7 5639 6 was be VBD cord-005453-4057qib7 5639 7 performed perform VBN cord-005453-4057qib7 5639 8 by by IN cord-005453-4057qib7 5639 9 AQUIOS AQUIOS NNP cord-005453-4057qib7 5639 10 CL CL NNP cord-005453-4057qib7 5639 11 Flow Flow NNP cord-005453-4057qib7 5639 12 Cytometer Cytometer NNP cord-005453-4057qib7 5639 13 ( ( -LRB- cord-005453-4057qib7 5639 14 Beckman Beckman NNP cord-005453-4057qib7 5639 15 Coulter Coulter NNP cord-005453-4057qib7 5639 16 ) ) -RRB- cord-005453-4057qib7 5639 17 , , , cord-005453-4057qib7 5639 18 a a DT cord-005453-4057qib7 5639 19 quantitative quantitative JJ cord-005453-4057qib7 5639 20 automated automate VBN cord-005453-4057qib7 5639 21 analyzer analyzer NN cord-005453-4057qib7 5639 22 that that WDT cord-005453-4057qib7 5639 23 performs perform VBZ cord-005453-4057qib7 5639 24 two two CD cord-005453-4057qib7 5639 25 diagnostic diagnostic JJ cord-005453-4057qib7 5639 26 panels panel NNS cord-005453-4057qib7 5639 27 : : : cord-005453-4057qib7 5640 1 Tetra-1 Tetra-1 NNP cord-005453-4057qib7 5640 2 CD45-FITC CD45-FITC NNP cord-005453-4057qib7 5640 3 / / SYM cord-005453-4057qib7 5640 4 CD4-RD1/ CD4-RD1/ NNP cord-005453-4057qib7 5640 5 CD8-ECD CD8-ECD NNP cord-005453-4057qib7 5640 6 / / SYM cord-005453-4057qib7 5640 7 CD3-PC5 CD3-PC5 NNP cord-005453-4057qib7 5640 8 and and CC cord-005453-4057qib7 5640 9 Tetra-2 Tetra-2 NNPS cord-005453-4057qib7 5640 10 CD45-FITC CD45-FITC NNP cord-005453-4057qib7 5640 11 / / SYM cord-005453-4057qib7 5640 12 CD56 CD56 NNP cord-005453-4057qib7 5640 13 + + CC cord-005453-4057qib7 5640 14 CD16-RD1 cd16-rd1 NN cord-005453-4057qib7 5640 15 / / SYM cord-005453-4057qib7 5640 16 CD19-ECD cd19-ecd NN cord-005453-4057qib7 5640 17 / / SYM cord-005453-4057qib7 5640 18 CD3-PC5 cd3-pc5 NN cord-005453-4057qib7 5640 19 . . . cord-005453-4057qib7 5641 1 B b NN cord-005453-4057qib7 5641 2 cell cell NN cord-005453-4057qib7 5641 3 subsets subset NNS cord-005453-4057qib7 5641 4 ( ( -LRB- cord-005453-4057qib7 5641 5 Memory memory NN cord-005453-4057qib7 5641 6 , , , cord-005453-4057qib7 5641 7 Mature Mature NNP cord-005453-4057qib7 5641 8 and and CC cord-005453-4057qib7 5641 9 Transitional Transitional NNP cord-005453-4057qib7 5641 10 B B NNP cord-005453-4057qib7 5641 11 cells cell NNS cord-005453-4057qib7 5641 12 ) ) -RRB- cord-005453-4057qib7 5641 13 on on IN cord-005453-4057qib7 5641 14 peripheral peripheral JJ cord-005453-4057qib7 5641 15 blood blood NN cord-005453-4057qib7 5641 16 samples sample NNS cord-005453-4057qib7 5641 17 were be VBD cord-005453-4057qib7 5641 18 analyzed analyze VBN cord-005453-4057qib7 5641 19 by by IN cord-005453-4057qib7 5641 20 AQUIOS AQUIOS NNP cord-005453-4057qib7 5641 21 Designer Designer NNP cord-005453-4057qib7 5641 22 Software Software NNP cord-005453-4057qib7 5641 23 , , , cord-005453-4057qib7 5641 24 a a DT cord-005453-4057qib7 5641 25 tool tool NN cord-005453-4057qib7 5641 26 for for IN cord-005453-4057qib7 5641 27 the the DT cord-005453-4057qib7 5641 28 creation creation NN cord-005453-4057qib7 5641 29 of of IN cord-005453-4057qib7 5641 30 user user NN cord-005453-4057qib7 5641 31 - - HYPH cord-005453-4057qib7 5641 32 defined define VBN cord-005453-4057qib7 5641 33 applications application NNS cord-005453-4057qib7 5641 34 . . . cord-005453-4057qib7 5642 1 Panel-1 Panel-1 NNP cord-005453-4057qib7 5643 1 CD19-FITC CD19-FITC NNP cord-005453-4057qib7 5643 2 / / SYM cord-005453-4057qib7 5643 3 CD10-PE CD10-PE NNP cord-005453-4057qib7 5643 4 / / SYM cord-005453-4057qib7 5643 5 CD38-ECD CD38-ECD NNP cord-005453-4057qib7 5643 6 / / SYM cord-005453-4057qib7 5643 7 CD24-PC5 CD24-PC5 NNP cord-005453-4057qib7 5643 8 / / SYM cord-005453-4057qib7 5643 9 CD27-PC7 CD27-PC7 NNP cord-005453-4057qib7 5643 10 and and CC cord-005453-4057qib7 5643 11 Panel-2 Panel-2 NNP cord-005453-4057qib7 5644 1 CD19-FITC CD19-FITC NNP cord-005453-4057qib7 5644 2 / / SYM cord-005453-4057qib7 5644 3 CD5-PE cd5-pe NN cord-005453-4057qib7 5644 4 / / SYM cord-005453-4057qib7 5644 5 CD38-ECD CD38-ECD NNP cord-005453-4057qib7 5644 6 / / SYM cord-005453-4057qib7 5644 7 CD24-PC5/ CD24-PC5/ NNP cord-005453-4057qib7 5644 8 CD20-PC7 CD20-PC7 NNS cord-005453-4057qib7 5644 9 were be VBD cord-005453-4057qib7 5644 10 specifically specifically RB cord-005453-4057qib7 5644 11 designed design VBN cord-005453-4057qib7 5644 12 by by IN cord-005453-4057qib7 5644 13 Beckman Beckman NNP cord-005453-4057qib7 5644 14 Coulter Coulter NNP cord-005453-4057qib7 5644 15 for for IN cord-005453-4057qib7 5644 16 our -PRON- PRP$ cord-005453-4057qib7 5644 17 center center NN cord-005453-4057qib7 5644 18 . . . cord-005453-4057qib7 5645 1 The the DT cord-005453-4057qib7 5645 2 flow flow NN cord-005453-4057qib7 5645 3 cytometric cytometric NN cord-005453-4057qib7 5645 4 analysis analysis NN cord-005453-4057qib7 5645 5 was be VBD cord-005453-4057qib7 5645 6 performed perform VBN cord-005453-4057qib7 5645 7 as as IN cord-005453-4057qib7 5645 8 follows follow VBZ cord-005453-4057qib7 5645 9 : : : cord-005453-4057qib7 5645 10 in in IN cord-005453-4057qib7 5645 11 donors donor NNS cord-005453-4057qib7 5645 12 and and CC cord-005453-4057qib7 5645 13 patients patient NNS cord-005453-4057qib7 5645 14 at at IN cord-005453-4057qib7 5645 15 basal basal NN cord-005453-4057qib7 5645 16 level level NN cord-005453-4057qib7 5645 17 ; ; : cord-005453-4057qib7 5645 18 on on IN cord-005453-4057qib7 5645 19 graft graft NN cord-005453-4057qib7 5645 20 products product NNS cord-005453-4057qib7 5645 21 and and CC cord-005453-4057qib7 5645 22 in in IN cord-005453-4057qib7 5645 23 patients patient NNS cord-005453-4057qib7 5645 24 at at IN cord-005453-4057qib7 5645 25 days day NNS cord-005453-4057qib7 5645 26 +30 +30 CD cord-005453-4057qib7 5645 27 , , , cord-005453-4057qib7 5645 28 +60 +60 NNP cord-005453-4057qib7 5645 29 , , , cord-005453-4057qib7 5645 30 +90 +90 CD cord-005453-4057qib7 5645 31 , , , cord-005453-4057qib7 5645 32 +120 +120 NNP cord-005453-4057qib7 5645 33 after after IN cord-005453-4057qib7 5645 34 HSCT HSCT NNP cord-005453-4057qib7 5645 35 . . . cord-005453-4057qib7 5646 1 Statistical statistical JJ cord-005453-4057qib7 5646 2 significance significance NN cord-005453-4057qib7 5646 3 was be VBD cord-005453-4057qib7 5646 4 assessed assess VBN cord-005453-4057qib7 5646 5 with with IN cord-005453-4057qib7 5646 6 Prism Prism NNP cord-005453-4057qib7 5646 7 software software NN cord-005453-4057qib7 5646 8 ( ( -LRB- cord-005453-4057qib7 5646 9 GraphPad GraphPad NNP cord-005453-4057qib7 5646 10 ) ) -RRB- cord-005453-4057qib7 5646 11 by by IN cord-005453-4057qib7 5646 12 Mann Mann NNP cord-005453-4057qib7 5646 13 Withney Withney NNP cord-005453-4057qib7 5646 14 test test NN cord-005453-4057qib7 5646 15 . . . cord-005453-4057qib7 5647 1 P p NN cord-005453-4057qib7 5647 2 < < XX cord-005453-4057qib7 5647 3 0.05 0.05 CD cord-005453-4057qib7 5647 4 was be VBD cord-005453-4057qib7 5647 5 considered consider VBN cord-005453-4057qib7 5647 6 statistically statistically RB cord-005453-4057qib7 5647 7 significant significant JJ cord-005453-4057qib7 5647 8 . . . cord-005453-4057qib7 5648 1 Results result NNS cord-005453-4057qib7 5648 2 : : : cord-005453-4057qib7 5649 1 Actually actually RB cord-005453-4057qib7 5649 2 we -PRON- PRP cord-005453-4057qib7 5649 3 enrolled enrol VBD cord-005453-4057qib7 5649 4 84 84 CD cord-005453-4057qib7 5649 5 patients patient NNS cord-005453-4057qib7 5649 6 submitted submit VBN cord-005453-4057qib7 5649 7 to to IN cord-005453-4057qib7 5649 8 HSCT HSCT NNP cord-005453-4057qib7 5649 9 in in IN cord-005453-4057qib7 5649 10 our -PRON- PRP$ cord-005453-4057qib7 5649 11 center center NN cord-005453-4057qib7 5649 12 from from IN cord-005453-4057qib7 5649 13 November November NNP cord-005453-4057qib7 5649 14 2017 2017 CD cord-005453-4057qib7 5649 15 . . . cord-005453-4057qib7 5650 1 A a DT cord-005453-4057qib7 5650 2 preliminary preliminary JJ cord-005453-4057qib7 5650 3 statistical statistical JJ cord-005453-4057qib7 5650 4 analysis analysis NN cord-005453-4057qib7 5650 5 was be VBD cord-005453-4057qib7 5650 6 performed perform VBN cord-005453-4057qib7 5650 7 on on IN cord-005453-4057qib7 5650 8 55 55 CD cord-005453-4057qib7 5650 9 patients patient NNS cord-005453-4057qib7 5650 10 . . . cord-005453-4057qib7 5651 1 Stem stem NN cord-005453-4057qib7 5651 2 cells cell NNS cord-005453-4057qib7 5651 3 source source NN cord-005453-4057qib7 5651 4 was be VBD cord-005453-4057qib7 5651 5 peripheral peripheral JJ cord-005453-4057qib7 5651 6 blood blood NN cord-005453-4057qib7 5651 7 ( ( -LRB- cord-005453-4057qib7 5651 8 PB PB NNP cord-005453-4057qib7 5651 9 ) ) -RRB- cord-005453-4057qib7 5651 10 in in IN cord-005453-4057qib7 5651 11 27 27 CD cord-005453-4057qib7 5651 12 cases case NNS cord-005453-4057qib7 5651 13 and and CC cord-005453-4057qib7 5651 14 bone bone NN cord-005453-4057qib7 5651 15 marrow marrow NN cord-005453-4057qib7 5651 16 ( ( -LRB- cord-005453-4057qib7 5651 17 BM BM NNP cord-005453-4057qib7 5651 18 ) ) -RRB- cord-005453-4057qib7 5651 19 in in IN cord-005453-4057qib7 5651 20 the the DT cord-005453-4057qib7 5651 21 others other NNS cord-005453-4057qib7 5651 22 28 28 CD cord-005453-4057qib7 5651 23 . . . cord-005453-4057qib7 5652 1 The the DT cord-005453-4057qib7 5652 2 conditioning conditioning NN cord-005453-4057qib7 5652 3 regimen regimen NN cord-005453-4057qib7 5652 4 was be VBD cord-005453-4057qib7 5652 5 myeloablative myeloablative JJ cord-005453-4057qib7 5652 6 in in IN cord-005453-4057qib7 5652 7 26 26 CD cord-005453-4057qib7 5652 8 patients patient NNS cord-005453-4057qib7 5652 9 and and CC cord-005453-4057qib7 5652 10 RIC RIC NNP cord-005453-4057qib7 5652 11 in in IN cord-005453-4057qib7 5652 12 29 29 CD cord-005453-4057qib7 5652 13 patients patient NNS cord-005453-4057qib7 5652 14 . . . cord-005453-4057qib7 5653 1 aGVHD aGVHD NNP cord-005453-4057qib7 5653 2 was be VBD cord-005453-4057qib7 5653 3 diagnosed diagnose VBN cord-005453-4057qib7 5653 4 in in IN cord-005453-4057qib7 5653 5 22 22 CD cord-005453-4057qib7 5653 6 patients patient NNS cord-005453-4057qib7 5653 7 ( ( -LRB- cord-005453-4057qib7 5653 8 40 40 CD cord-005453-4057qib7 5653 9 % % NN cord-005453-4057qib7 5653 10 ) ) -RRB- cord-005453-4057qib7 5653 11 . . . cord-005453-4057qib7 5654 1 No no DT cord-005453-4057qib7 5654 2 associations association NNS cord-005453-4057qib7 5654 3 were be VBD cord-005453-4057qib7 5654 4 found find VBN cord-005453-4057qib7 5654 5 between between IN cord-005453-4057qib7 5654 6 B b NN cord-005453-4057qib7 5654 7 cell cell NN cord-005453-4057qib7 5654 8 subsets subset NNS cord-005453-4057qib7 5654 9 in in IN cord-005453-4057qib7 5654 10 donors donor NNS cord-005453-4057qib7 5654 11 and and CC cord-005453-4057qib7 5654 12 patients patient NNS cord-005453-4057qib7 5654 13 at at IN cord-005453-4057qib7 5654 14 baseline baseline NN cord-005453-4057qib7 5654 15 and and CC cord-005453-4057qib7 5654 16 the the DT cord-005453-4057qib7 5654 17 occurrence occurrence NN cord-005453-4057qib7 5654 18 of of IN cord-005453-4057qib7 5654 19 aGVHD aGVHD NNP cord-005453-4057qib7 5654 20 . . . cord-005453-4057qib7 5655 1 However however RB cord-005453-4057qib7 5655 2 we -PRON- PRP cord-005453-4057qib7 5655 3 found find VBD cord-005453-4057qib7 5655 4 a a DT cord-005453-4057qib7 5655 5 higher high JJR cord-005453-4057qib7 5655 6 median median JJ cord-005453-4057qib7 5655 7 percentage percentage NN cord-005453-4057qib7 5655 8 of of IN cord-005453-4057qib7 5655 9 transitional transitional JJ cord-005453-4057qib7 5655 10 B b NN cord-005453-4057qib7 5655 11 cells cell NNS cord-005453-4057qib7 5655 12 in in IN cord-005453-4057qib7 5655 13 graft graft NN cord-005453-4057qib7 5655 14 products product NNS cord-005453-4057qib7 5655 15 in in IN cord-005453-4057qib7 5655 16 patients patient NNS cord-005453-4057qib7 5655 17 without without IN cord-005453-4057qib7 5655 18 aGVHD aGVHD NNP cord-005453-4057qib7 5655 19 ( ( -LRB- cord-005453-4057qib7 5655 20 9.6 9.6 CD cord-005453-4057qib7 5655 21 % % NN cord-005453-4057qib7 5655 22 , , , cord-005453-4057qib7 5655 23 4.5 4.5 CD cord-005453-4057qib7 5655 24 - - SYM cord-005453-4057qib7 5655 25 26.7 26.7 CD cord-005453-4057qib7 5655 26 ) ) -RRB- cord-005453-4057qib7 5655 27 compared compare VBN cord-005453-4057qib7 5655 28 to to IN cord-005453-4057qib7 5655 29 patients patient NNS cord-005453-4057qib7 5655 30 with with IN cord-005453-4057qib7 5655 31 aGvHD agvhd NN cord-005453-4057qib7 5655 32 ( ( -LRB- cord-005453-4057qib7 5655 33 6.9 6.9 CD cord-005453-4057qib7 5655 34 % % NN cord-005453-4057qib7 5655 35 , , , cord-005453-4057qib7 5655 36 1.5 1.5 CD cord-005453-4057qib7 5655 37 - - SYM cord-005453-4057qib7 5655 38 21.1 21.1 CD cord-005453-4057qib7 5655 39 ) ) -RRB- cord-005453-4057qib7 5656 1 ( ( -LRB- cord-005453-4057qib7 5656 2 p=0.02 p=0.02 NNP cord-005453-4057qib7 5656 3 , , , cord-005453-4057qib7 5656 4 Fig Fig NNP cord-005453-4057qib7 5656 5 1A 1a NN cord-005453-4057qib7 5656 6 ) ) -RRB- cord-005453-4057qib7 5656 7 . . . cord-005453-4057qib7 5657 1 In in IN cord-005453-4057qib7 5657 2 addition addition NN cord-005453-4057qib7 5657 3 , , , cord-005453-4057qib7 5657 4 patients patient NNS cord-005453-4057qib7 5657 5 without without IN cord-005453-4057qib7 5657 6 aGvHD aGvHD NNP cord-005453-4057qib7 5657 7 showed show VBD cord-005453-4057qib7 5657 8 a a DT cord-005453-4057qib7 5657 9 lower low JJR cord-005453-4057qib7 5657 10 median median JJ cord-005453-4057qib7 5657 11 percentage percentage NN cord-005453-4057qib7 5657 12 of of IN cord-005453-4057qib7 5657 13 memory memory NN cord-005453-4057qib7 5657 14 B b NN cord-005453-4057qib7 5657 15 cells cell NNS cord-005453-4057qib7 5657 16 ( ( -LRB- cord-005453-4057qib7 5657 17 24.2 24.2 CD cord-005453-4057qib7 5657 18 % % NN cord-005453-4057qib7 5657 19 , , , cord-005453-4057qib7 5657 20 range range VBP cord-005453-4057qib7 5657 21 11.6 11.6 CD cord-005453-4057qib7 5657 22 - - SYM cord-005453-4057qib7 5657 23 49 49 CD cord-005453-4057qib7 5657 24 ) ) -RRB- cord-005453-4057qib7 5657 25 in in IN cord-005453-4057qib7 5657 26 graft graft NN cord-005453-4057qib7 5657 27 product product NN cord-005453-4057qib7 5657 28 as as IN cord-005453-4057qib7 5657 29 compared compare VBN cord-005453-4057qib7 5657 30 to to IN cord-005453-4057qib7 5657 31 patients patient NNS cord-005453-4057qib7 5657 32 with with IN cord-005453-4057qib7 5657 33 aGvHD agvhd NN cord-005453-4057qib7 5657 34 ( ( -LRB- cord-005453-4057qib7 5657 35 34.2 34.2 CD cord-005453-4057qib7 5657 36 % % NN cord-005453-4057qib7 5657 37 , , , cord-005453-4057qib7 5657 38 range range NN cord-005453-4057qib7 5657 39 10.3 10.3 CD cord-005453-4057qib7 5657 40 - - HYPH cord-005453-4057qib7 5657 41 68.15 68.15 CD cord-005453-4057qib7 5657 42 ) ) -RRB- cord-005453-4057qib7 5658 1 ( ( -LRB- cord-005453-4057qib7 5658 2 p p NN cord-005453-4057qib7 5658 3 = = SYM cord-005453-4057qib7 5658 4 0.03 0.03 CD cord-005453-4057qib7 5658 5 , , , cord-005453-4057qib7 5658 6 Fig.1B Fig.1B NNP cord-005453-4057qib7 5658 7 ) ) -RRB- cord-005453-4057qib7 5658 8 . . . cord-005453-4057qib7 5659 1 Finally finally RB cord-005453-4057qib7 5659 2 in in IN cord-005453-4057qib7 5659 3 the the DT cord-005453-4057qib7 5659 4 subgroup subgroup NN cord-005453-4057qib7 5659 5 of of IN cord-005453-4057qib7 5659 6 patients patient NNS cord-005453-4057qib7 5659 7 receiving receive VBG cord-005453-4057qib7 5659 8 PB PB NNP cord-005453-4057qib7 5659 9 as as IN cord-005453-4057qib7 5659 10 stem stem NN cord-005453-4057qib7 5659 11 cell cell NN cord-005453-4057qib7 5659 12 source source NN cord-005453-4057qib7 5659 13 we -PRON- PRP cord-005453-4057qib7 5659 14 observed observe VBD cord-005453-4057qib7 5659 15 a a DT cord-005453-4057qib7 5659 16 higher high JJR cord-005453-4057qib7 5659 17 percentage percentage NN cord-005453-4057qib7 5659 18 of of IN cord-005453-4057qib7 5659 19 CD3 CD3 NNP cord-005453-4057qib7 5659 20 + + CC cord-005453-4057qib7 5659 21 lymphocytes lymphocyte NNS cord-005453-4057qib7 5659 22 in in IN cord-005453-4057qib7 5659 23 graft graft NN cord-005453-4057qib7 5659 24 product product NN cord-005453-4057qib7 5659 25 in in IN cord-005453-4057qib7 5659 26 patients patient NNS cord-005453-4057qib7 5659 27 with with IN cord-005453-4057qib7 5659 28 aGVHD aGVHD NNP cord-005453-4057qib7 5659 29 ( ( -LRB- cord-005453-4057qib7 5659 30 75 75 CD cord-005453-4057qib7 5659 31 % % NN cord-005453-4057qib7 5659 32 ; ; : cord-005453-4057qib7 5659 33 range range VBP cord-005453-4057qib7 5659 34 68 68 CD cord-005453-4057qib7 5659 35 - - SYM cord-005453-4057qib7 5659 36 80 80 CD cord-005453-4057qib7 5659 37 ) ) -RRB- cord-005453-4057qib7 5659 38 compared compare VBN cord-005453-4057qib7 5659 39 to to IN cord-005453-4057qib7 5659 40 patients patient NNS cord-005453-4057qib7 5659 41 without without IN cord-005453-4057qib7 5659 42 aGVHD aGVHD NNP cord-005453-4057qib7 5659 43 ( ( -LRB- cord-005453-4057qib7 5659 44 71 71 CD cord-005453-4057qib7 5659 45 % % NN cord-005453-4057qib7 5659 46 ; ; : cord-005453-4057qib7 5659 47 range range VBP cord-005453-4057qib7 5659 48 62 62 CD cord-005453-4057qib7 5659 49 - - SYM cord-005453-4057qib7 5659 50 78 78 CD cord-005453-4057qib7 5659 51 ) ) -RRB- cord-005453-4057qib7 5659 52 ( ( -LRB- cord-005453-4057qib7 5659 53 p=0.01 p=0.01 NNP cord-005453-4057qib7 5659 54 ) ) -RRB- cord-005453-4057qib7 5659 55 . . . cord-005453-4057qib7 5660 1 In in IN cord-005453-4057qib7 5660 2 the the DT cord-005453-4057qib7 5660 3 monitoring monitoring NN cord-005453-4057qib7 5660 4 of of IN cord-005453-4057qib7 5660 5 B b NN cord-005453-4057qib7 5660 6 cells cell NNS cord-005453-4057qib7 5660 7 reconstitution reconstitution NN cord-005453-4057qib7 5660 8 we -PRON- PRP cord-005453-4057qib7 5660 9 observed observe VBD cord-005453-4057qib7 5660 10 that that IN cord-005453-4057qib7 5660 11 CD19 CD19 NNP cord-005453-4057qib7 5660 12 + + SYM cord-005453-4057qib7 5660 13 events event NNS cord-005453-4057qib7 5660 14 did do VBD cord-005453-4057qib7 5660 15 not not RB cord-005453-4057qib7 5660 16 appear appear VB cord-005453-4057qib7 5660 17 before before IN cord-005453-4057qib7 5660 18 day day NN cord-005453-4057qib7 5660 19 +90 +90 CD cord-005453-4057qib7 5660 20 after after IN cord-005453-4057qib7 5660 21 HSCT HSCT NNP cord-005453-4057qib7 5660 22 and and CC cord-005453-4057qib7 5660 23 these these DT cord-005453-4057qib7 5660 24 were be VBD cord-005453-4057qib7 5660 25 B b NN cord-005453-4057qib7 5660 26 transitional transitional JJ cord-005453-4057qib7 5660 27 immature immature JJ cord-005453-4057qib7 5660 28 events event NNS cord-005453-4057qib7 5660 29 predominantly predominantly RB cord-005453-4057qib7 5660 30 . . . cord-005453-4057qib7 5661 1 Conclusions conclusion NNS cord-005453-4057qib7 5661 2 : : : cord-005453-4057qib7 5662 1 Our -PRON- PRP$ cord-005453-4057qib7 5662 2 data datum NNS cord-005453-4057qib7 5662 3 suggest suggest VBP cord-005453-4057qib7 5662 4 a a DT cord-005453-4057qib7 5662 5 possible possible JJ cord-005453-4057qib7 5662 6 protective protective JJ cord-005453-4057qib7 5662 7 link link NN cord-005453-4057qib7 5662 8 between between IN cord-005453-4057qib7 5662 9 transitional transitional JJ cord-005453-4057qib7 5662 10 B b NN cord-005453-4057qib7 5662 11 cells cell NNS cord-005453-4057qib7 5662 12 and and CC cord-005453-4057qib7 5662 13 aGvHD agvhd NN cord-005453-4057qib7 5662 14 development development NN cord-005453-4057qib7 5662 15 . . . cord-005453-4057qib7 5663 1 These these DT cord-005453-4057qib7 5663 2 results result NNS cord-005453-4057qib7 5663 3 data datum NNS cord-005453-4057qib7 5663 4 need need VBP cord-005453-4057qib7 5663 5 to to TO cord-005453-4057qib7 5663 6 be be VB cord-005453-4057qib7 5663 7 confirmed confirm VBN cord-005453-4057qib7 5663 8 in in IN cord-005453-4057qib7 5663 9 a a DT cord-005453-4057qib7 5663 10 larger large JJR cord-005453-4057qib7 5663 11 cohort cohort NN cord-005453-4057qib7 5663 12 of of IN cord-005453-4057qib7 5663 13 patients patient NNS cord-005453-4057qib7 5663 14 . . . cord-005453-4057qib7 5664 1 Moreover moreover RB cord-005453-4057qib7 5664 2 , , , cord-005453-4057qib7 5664 3 it -PRON- PRP cord-005453-4057qib7 5664 4 will will MD cord-005453-4057qib7 5664 5 be be VB cord-005453-4057qib7 5664 6 interesting interesting JJ cord-005453-4057qib7 5664 7 to to TO cord-005453-4057qib7 5664 8 evaluate evaluate VB cord-005453-4057qib7 5664 9 the the DT cord-005453-4057qib7 5664 10 relationship relationship NN cord-005453-4057qib7 5664 11 between between IN cord-005453-4057qib7 5664 12 transitional transitional JJ cord-005453-4057qib7 5664 13 B B NNP cord-005453-4057qib7 5664 14 cells cell NNS cord-005453-4057qib7 5664 15 at at IN cord-005453-4057qib7 5664 16 day day NN cord-005453-4057qib7 5664 17 +90 +90 CD cord-005453-4057qib7 5664 18 and and CC cord-005453-4057qib7 5664 19 the the DT cord-005453-4057qib7 5664 20 occurrence occurrence NN cord-005453-4057qib7 5664 21 of of IN cord-005453-4057qib7 5664 22 cGVHD cGVHD NNP cord-005453-4057qib7 5664 23 . . . cord-005453-4057qib7 5665 1 Clinical clinical JJ cord-005453-4057qib7 5665 2 Background background NN cord-005453-4057qib7 5665 3 : : : cord-005453-4057qib7 5666 1 aGVHD aGVHD NNP cord-005453-4057qib7 5666 2 is be VBZ cord-005453-4057qib7 5666 3 a a DT cord-005453-4057qib7 5666 4 major major JJ cord-005453-4057qib7 5666 5 complication complication NN cord-005453-4057qib7 5666 6 of of IN cord-005453-4057qib7 5666 7 allogeneic allogeneic JJ cord-005453-4057qib7 5666 8 hematopoietic hematopoietic JJ cord-005453-4057qib7 5666 9 stem stem NN cord-005453-4057qib7 5666 10 cell cell NN cord-005453-4057qib7 5666 11 transplant transplant NN cord-005453-4057qib7 5666 12 ( ( -LRB- cord-005453-4057qib7 5666 13 HSCT HSCT NNP cord-005453-4057qib7 5666 14 ) ) -RRB- cord-005453-4057qib7 5666 15 and and CC cord-005453-4057qib7 5666 16 a a DT cord-005453-4057qib7 5666 17 risk risk NN cord-005453-4057qib7 5666 18 factor factor NN cord-005453-4057qib7 5666 19 for for IN cord-005453-4057qib7 5666 20 post post JJ cord-005453-4057qib7 5666 21 - - JJ cord-005453-4057qib7 5666 22 HSCT hsct JJ cord-005453-4057qib7 5666 23 mortality mortality NN cord-005453-4057qib7 5666 24 . . . cord-005453-4057qib7 5667 1 The the DT cord-005453-4057qib7 5667 2 objective objective NN cord-005453-4057qib7 5667 3 of of IN cord-005453-4057qib7 5667 4 this this DT cord-005453-4057qib7 5667 5 analysis analysis NN cord-005453-4057qib7 5667 6 is be VBZ cord-005453-4057qib7 5667 7 to to TO cord-005453-4057qib7 5667 8 describe describe VB cord-005453-4057qib7 5667 9 patients patient NNS cord-005453-4057qib7 5667 10 with with IN cord-005453-4057qib7 5667 11 aGVHD aGVHD NNP cord-005453-4057qib7 5667 12 who who WP cord-005453-4057qib7 5667 13 had have VBD cord-005453-4057qib7 5667 14 a a DT cord-005453-4057qib7 5667 15 suboptimal suboptimal JJ cord-005453-4057qib7 5667 16 response response NN cord-005453-4057qib7 5667 17 to to IN cord-005453-4057qib7 5667 18 corticosteroids corticosteroid NNS cord-005453-4057qib7 5667 19 . . . cord-005453-4057qib7 5668 1 Methods method NNS cord-005453-4057qib7 5668 2 : : : cord-005453-4057qib7 5668 3 Patients patient NNS cord-005453-4057qib7 5668 4 who who WP cord-005453-4057qib7 5668 5 developed develop VBD cord-005453-4057qib7 5668 6 IBMTR IBMTR NNP cord-005453-4057qib7 5668 7 Severity Severity NNP cord-005453-4057qib7 5668 8 Index Index NNP cord-005453-4057qib7 5668 9 II II NNP cord-005453-4057qib7 5668 10 - - HYPH cord-005453-4057qib7 5668 11 IV IV NNP cord-005453-4057qib7 5668 12 aGVHD aGVHD NNP cord-005453-4057qib7 5669 1 after after IN cord-005453-4057qib7 5669 2 first first JJ cord-005453-4057qib7 5669 3 HSCT HSCT NNP cord-005453-4057qib7 5669 4 between between IN cord-005453-4057qib7 5669 5 1/1/14 1/1/14 CD cord-005453-4057qib7 5669 6 to to IN cord-005453-4057qib7 5669 7 6/ 6/ CD cord-005453-4057qib7 5669 8 30/16 30/16 CD cord-005453-4057qib7 5669 9 were be VBD cord-005453-4057qib7 5669 10 included include VBN cord-005453-4057qib7 5669 11 in in IN cord-005453-4057qib7 5669 12 an an DT cord-005453-4057qib7 5669 13 ongoing ongoing JJ cord-005453-4057qib7 5669 14 chart chart NN cord-005453-4057qib7 5669 15 review review NN cord-005453-4057qib7 5669 16 at at IN cord-005453-4057qib7 5669 17 centers center NNS cord-005453-4057qib7 5669 18 in in IN cord-005453-4057qib7 5669 19 the the DT cord-005453-4057qib7 5669 20 United United NNP cord-005453-4057qib7 5669 21 States States NNP cord-005453-4057qib7 5669 22 . . . cord-005453-4057qib7 5670 1 Patients patient NNS cord-005453-4057qib7 5670 2 who who WP cord-005453-4057qib7 5670 3 had have VBD cord-005453-4057qib7 5670 4 ever ever RB cord-005453-4057qib7 5670 5 participated participate VBN cord-005453-4057qib7 5670 6 in in IN cord-005453-4057qib7 5670 7 a a DT cord-005453-4057qib7 5670 8 GVHD GVHD NNP cord-005453-4057qib7 5670 9 prophylaxis prophylaxis NN cord-005453-4057qib7 5670 10 trial trial NN cord-005453-4057qib7 5670 11 or or CC cord-005453-4057qib7 5670 12 used use VBD cord-005453-4057qib7 5670 13 JAK JAK NNP cord-005453-4057qib7 5670 14 inhibitors inhibitor NNS cord-005453-4057qib7 5670 15 were be VBD cord-005453-4057qib7 5670 16 excluded exclude VBN cord-005453-4057qib7 5670 17 from from IN cord-005453-4057qib7 5670 18 the the DT cord-005453-4057qib7 5670 19 study study NN cord-005453-4057qib7 5670 20 . . . cord-005453-4057qib7 5671 1 Suboptimal suboptimal JJ cord-005453-4057qib7 5671 2 response response NN cord-005453-4057qib7 5671 3 to to IN cord-005453-4057qib7 5671 4 corticosteroids corticosteroid NNS cord-005453-4057qib7 5671 5 was be VBD cord-005453-4057qib7 5671 6 defined define VBN cord-005453-4057qib7 5671 7 as as IN cord-005453-4057qib7 5671 8 use use NN cord-005453-4057qib7 5671 9 of of IN cord-005453-4057qib7 5671 10 additional additional JJ cord-005453-4057qib7 5671 11 systemic systemic JJ cord-005453-4057qib7 5671 12 anti anti JJ cord-005453-4057qib7 5671 13 - - JJ cord-005453-4057qib7 5671 14 GVHD gvhd JJ cord-005453-4057qib7 5671 15 therapy therapy NN cord-005453-4057qib7 5671 16 , , , cord-005453-4057qib7 5671 17 inability inability NN cord-005453-4057qib7 5671 18 to to TO cord-005453-4057qib7 5671 19 taper taper VB cord-005453-4057qib7 5671 20 high high JJ cord-005453-4057qib7 5671 21 - - HYPH cord-005453-4057qib7 5671 22 dose dose NN cord-005453-4057qib7 5671 23 steroids steroid NNS cord-005453-4057qib7 5671 24 ( ( -LRB- cord-005453-4057qib7 5671 25 ≥1 ≥1 NNP cord-005453-4057qib7 5671 26 mg/ mg/ NNP cord-005453-4057qib7 5671 27 kg kg NNP cord-005453-4057qib7 5671 28 ) ) -RRB- cord-005453-4057qib7 5671 29 by by IN cord-005453-4057qib7 5671 30 ≥25 ≥25 NNP cord-005453-4057qib7 5671 31 % % NN cord-005453-4057qib7 5671 32 , , , cord-005453-4057qib7 5671 33 or or CC cord-005453-4057qib7 5671 34 tapered tapered JJ cord-005453-4057qib7 5671 35 corticosteroids corticosteroid NNS cord-005453-4057qib7 5671 36 by by IN cord-005453-4057qib7 5671 37 ≥25 ≥25 NNP cord-005453-4057qib7 5671 38 % % NN cord-005453-4057qib7 5671 39 but but CC cord-005453-4057qib7 5671 40 not not RB cord-005453-4057qib7 5671 41 to to IN cord-005453-4057qib7 5671 42 < < XX cord-005453-4057qib7 5671 43 10 10 CD cord-005453-4057qib7 5671 44 mg mg NNP cord-005453-4057qib7 5671 45 / / SYM cord-005453-4057qib7 5671 46 day day NN cord-005453-4057qib7 5671 47 . . . cord-005453-4057qib7 5672 1 Results result NNS cord-005453-4057qib7 5672 2 : : : cord-005453-4057qib7 5673 1 The the DT cord-005453-4057qib7 5673 2 analysis analysis NN cord-005453-4057qib7 5673 3 included include VBD cord-005453-4057qib7 5673 4 64 64 CD cord-005453-4057qib7 5673 5 patients patient NNS cord-005453-4057qib7 5673 6 with with IN cord-005453-4057qib7 5673 7 suboptimal suboptimal JJ cord-005453-4057qib7 5673 8 response response NN cord-005453-4057qib7 5673 9 to to IN cord-005453-4057qib7 5673 10 corticosteroids corticosteroid NNS cord-005453-4057qib7 5673 11 . . . cord-005453-4057qib7 5674 1 Mean mean JJ cord-005453-4057qib7 5674 2 age age NN cord-005453-4057qib7 5674 3 was be VBD cord-005453-4057qib7 5674 4 55 55 CD cord-005453-4057qib7 5674 5 years year NNS cord-005453-4057qib7 5674 6 ; ; : cord-005453-4057qib7 5674 7 66 66 CD cord-005453-4057qib7 5674 8 % % NN cord-005453-4057qib7 5674 9 were be VBD cord-005453-4057qib7 5674 10 male male JJ cord-005453-4057qib7 5674 11 . . . cord-005453-4057qib7 5675 1 Median median JJ cord-005453-4057qib7 5675 2 time time NN cord-005453-4057qib7 5675 3 from from IN cord-005453-4057qib7 5675 4 transplant transplant NN cord-005453-4057qib7 5675 5 to to IN cord-005453-4057qib7 5675 6 aGVHD aGVHD NNP cord-005453-4057qib7 5675 7 diagnosis diagnosis NN cord-005453-4057qib7 5675 8 was be VBD cord-005453-4057qib7 5675 9 33 33 CD cord-005453-4057qib7 5675 10 days day NNS cord-005453-4057qib7 5675 11 . . . cord-005453-4057qib7 5676 1 At at IN cord-005453-4057qib7 5676 2 the the DT cord-005453-4057qib7 5676 3 time time NN cord-005453-4057qib7 5676 4 of of IN cord-005453-4057qib7 5676 5 maximum maximum JJ cord-005453-4057qib7 5676 6 aGVHD aGVHD NNP cord-005453-4057qib7 5676 7 grade grade NN cord-005453-4057qib7 5676 8 , , , cord-005453-4057qib7 5676 9 33 33 CD cord-005453-4057qib7 5676 10 % % NN cord-005453-4057qib7 5676 11 of of IN cord-005453-4057qib7 5676 12 patients patient NNS cord-005453-4057qib7 5676 13 were be VBD cord-005453-4057qib7 5676 14 grade grade NN cord-005453-4057qib7 5676 15 II II NNP cord-005453-4057qib7 5676 16 and and CC cord-005453-4057qib7 5676 17 66 66 CD cord-005453-4057qib7 5676 18 % % NN cord-005453-4057qib7 5676 19 were be VBD cord-005453-4057qib7 5676 20 grade grade NN cord-005453-4057qib7 5676 21 III III NNP cord-005453-4057qib7 5676 22 - - HYPH cord-005453-4057qib7 5676 23 IV IV NNP cord-005453-4057qib7 5676 24 ; ; : cord-005453-4057qib7 5676 25 58 58 CD cord-005453-4057qib7 5676 26 % % NN cord-005453-4057qib7 5676 27 had have VBD cord-005453-4057qib7 5676 28 lower low JJR cord-005453-4057qib7 5676 29 GI GI NNP cord-005453-4057qib7 5676 30 involvement involvement NN cord-005453-4057qib7 5676 31 , , , cord-005453-4057qib7 5676 32 and and CC cord-005453-4057qib7 5676 33 59 59 CD cord-005453-4057qib7 5676 34 % % NN cord-005453-4057qib7 5676 35 had have VBD cord-005453-4057qib7 5676 36 ≥2 ≥2 NNP cord-005453-4057qib7 5676 37 organs organ NNS cord-005453-4057qib7 5676 38 involved involve VBN cord-005453-4057qib7 5676 39 . . . cord-005453-4057qib7 5677 1 From from IN cord-005453-4057qib7 5677 2 time time NN cord-005453-4057qib7 5677 3 of of IN cord-005453-4057qib7 5677 4 diagnosis diagnosis NN cord-005453-4057qib7 5677 5 to to TO cord-005453-4057qib7 5677 6 maximum maximum VB cord-005453-4057qib7 5677 7 aGVHD aGVHD NNP cord-005453-4057qib7 5677 8 grade grade NN cord-005453-4057qib7 5677 9 , , , cord-005453-4057qib7 5677 10 52 52 CD cord-005453-4057qib7 5677 11 % % NN cord-005453-4057qib7 5677 12 of of IN cord-005453-4057qib7 5677 13 patients patient NNS cord-005453-4057qib7 5677 14 had have VBD cord-005453-4057qib7 5677 15 new new JJ cord-005453-4057qib7 5677 16 organ organ NN cord-005453-4057qib7 5677 17 involvement involvement NN cord-005453-4057qib7 5677 18 or or CC cord-005453-4057qib7 5677 19 an an DT cord-005453-4057qib7 5677 20 increase increase NN cord-005453-4057qib7 5677 21 in in IN cord-005453-4057qib7 5677 22 aGVHD aGVHD NNP cord-005453-4057qib7 5677 23 grade grade NN cord-005453-4057qib7 5677 24 . . . cord-005453-4057qib7 5678 1 Median median JJ cord-005453-4057qib7 5678 2 time time NN cord-005453-4057qib7 5678 3 from from IN cord-005453-4057qib7 5678 4 diagnosis diagnosis NN cord-005453-4057qib7 5678 5 to to IN cord-005453-4057qib7 5678 6 maximum maximum JJ cord-005453-4057qib7 5678 7 grade grade NN cord-005453-4057qib7 5678 8 was be VBD cord-005453-4057qib7 5678 9 5.5 5.5 CD cord-005453-4057qib7 5678 10 days day NNS cord-005453-4057qib7 5678 11 , , , cord-005453-4057qib7 5678 12 and and CC cord-005453-4057qib7 5678 13 was be VBD cord-005453-4057qib7 5678 14 2.5 2.5 CD cord-005453-4057qib7 5678 15 days day NNS cord-005453-4057qib7 5678 16 for for IN cord-005453-4057qib7 5678 17 patients patient NNS cord-005453-4057qib7 5678 18 with with IN cord-005453-4057qib7 5678 19 lower low JJR cord-005453-4057qib7 5678 20 GI GI NNP cord-005453-4057qib7 5678 21 involvement involvement NN cord-005453-4057qib7 5678 22 . . . cord-005453-4057qib7 5679 1 Systemic systemic JJ cord-005453-4057qib7 5679 2 corticosteroids corticosteroid NNS cord-005453-4057qib7 5679 3 were be VBD cord-005453-4057qib7 5679 4 initiated initiate VBN cord-005453-4057qib7 5679 5 on on IN cord-005453-4057qib7 5679 6 the the DT cord-005453-4057qib7 5679 7 day day NN cord-005453-4057qib7 5679 8 of of IN cord-005453-4057qib7 5679 9 diagnosis diagnosis NN cord-005453-4057qib7 5679 10 for for IN cord-005453-4057qib7 5679 11 73 73 CD cord-005453-4057qib7 5679 12 % % NN cord-005453-4057qib7 5679 13 of of IN cord-005453-4057qib7 5679 14 patients patient NNS cord-005453-4057qib7 5679 15 . . . cord-005453-4057qib7 5680 1 Average average JJ cord-005453-4057qib7 5680 2 starting start VBG cord-005453-4057qib7 5680 3 daily daily RB cord-005453-4057qib7 5680 4 dose dose NN cord-005453-4057qib7 5680 5 was be VBD cord-005453-4057qib7 5680 6 93 93 CD cord-005453-4057qib7 5680 7 mg mg NN cord-005453-4057qib7 5680 8 ( ( -LRB- cord-005453-4057qib7 5680 9 1.1 1.1 CD cord-005453-4057qib7 5680 10 mg mg NNP cord-005453-4057qib7 5680 11 / / SYM cord-005453-4057qib7 5680 12 kg kg NNP cord-005453-4057qib7 5680 13 ) ) -RRB- cord-005453-4057qib7 5680 14 for for IN cord-005453-4057qib7 5680 15 prednisone prednisone NNP cord-005453-4057qib7 5680 16 and and CC cord-005453-4057qib7 5680 17 136 136 CD cord-005453-4057qib7 5680 18 mg mg NNS cord-005453-4057qib7 5680 19 ( ( -LRB- cord-005453-4057qib7 5680 20 1.6 1.6 CD cord-005453-4057qib7 5680 21 mg mg NNP cord-005453-4057qib7 5680 22 / / SYM cord-005453-4057qib7 5680 23 kg kg NNP cord-005453-4057qib7 5680 24 ) ) -RRB- cord-005453-4057qib7 5680 25 for for IN cord-005453-4057qib7 5680 26 methylprednisolone methylprednisolone NNP cord-005453-4057qib7 5680 27 . . . cord-005453-4057qib7 5681 1 Steroid steroid NN cord-005453-4057qib7 5681 2 dose dose NN cord-005453-4057qib7 5681 3 was be VBD cord-005453-4057qib7 5681 4 increased increase VBN cord-005453-4057qib7 5681 5 for for IN cord-005453-4057qib7 5681 6 44 44 CD cord-005453-4057qib7 5681 7 % % NN cord-005453-4057qib7 5681 8 of of IN cord-005453-4057qib7 5681 9 patients patient NNS cord-005453-4057qib7 5681 10 during during IN cord-005453-4057qib7 5681 11 follow follow NN cord-005453-4057qib7 5681 12 - - HYPH cord-005453-4057qib7 5681 13 up up NN cord-005453-4057qib7 5681 14 ; ; : cord-005453-4057qib7 5681 15 80 80 CD cord-005453-4057qib7 5681 16 % % NN cord-005453-4057qib7 5681 17 were be VBD cord-005453-4057qib7 5681 18 unable unable JJ cord-005453-4057qib7 5681 19 to to TO cord-005453-4057qib7 5681 20 taper taper VB cord-005453-4057qib7 5681 21 below below IN cord-005453-4057qib7 5681 22 10 10 CD cord-005453-4057qib7 5681 23 mg mg NNP cord-005453-4057qib7 5681 24 / / SYM cord-005453-4057qib7 5681 25 day day NN cord-005453-4057qib7 5681 26 . . . cord-005453-4057qib7 5682 1 Among among IN cord-005453-4057qib7 5682 2 patients patient NNS cord-005453-4057qib7 5682 3 who who WP cord-005453-4057qib7 5682 4 received receive VBD cord-005453-4057qib7 5682 5 additional additional JJ cord-005453-4057qib7 5682 6 systemic systemic JJ cord-005453-4057qib7 5682 7 anti anti JJ cord-005453-4057qib7 5682 8 - - JJ cord-005453-4057qib7 5682 9 GVHD gvhd JJ cord-005453-4057qib7 5682 10 therapy therapy NN cord-005453-4057qib7 5682 11 ( ( -LRB- cord-005453-4057qib7 5682 12 n=32 n=32 NNP cord-005453-4057qib7 5682 13 ) ) -RRB- cord-005453-4057qib7 5682 14 , , , cord-005453-4057qib7 5682 15 41 41 CD cord-005453-4057qib7 5682 16 % % NN cord-005453-4057qib7 5682 17 increased increase VBD cord-005453-4057qib7 5682 18 their -PRON- PRP$ cord-005453-4057qib7 5682 19 corticosteroid corticosteroid NN cord-005453-4057qib7 5682 20 dose dose NN cord-005453-4057qib7 5682 21 before before IN cord-005453-4057qib7 5682 22 initiation initiation NN cord-005453-4057qib7 5682 23 of of IN cord-005453-4057qib7 5682 24 additional additional JJ cord-005453-4057qib7 5682 25 anti anti JJ cord-005453-4057qib7 5682 26 - - JJ cord-005453-4057qib7 5682 27 GVHD gvhd JJ cord-005453-4057qib7 5682 28 therapy therapy NN cord-005453-4057qib7 5682 29 . . . cord-005453-4057qib7 5683 1 Median median JJ cord-005453-4057qib7 5683 2 time time NN cord-005453-4057qib7 5683 3 from from IN cord-005453-4057qib7 5683 4 initiation initiation NN cord-005453-4057qib7 5683 5 of of IN cord-005453-4057qib7 5683 6 corticosteroids corticosteroid NNS cord-005453-4057qib7 5683 7 to to IN cord-005453-4057qib7 5683 8 additional additional JJ cord-005453-4057qib7 5683 9 therapy therapy NN cord-005453-4057qib7 5683 10 was be VBD cord-005453-4057qib7 5683 11 16.5 16.5 CD cord-005453-4057qib7 5683 12 days day NNS cord-005453-4057qib7 5683 13 . . . cord-005453-4057qib7 5684 1 Frequently frequently RB cord-005453-4057qib7 5684 2 used use VBN cord-005453-4057qib7 5684 3 therapies therapy NNS cord-005453-4057qib7 5684 4 were be VBD cord-005453-4057qib7 5685 1 mycophenyalate mycophenyalate NNP cord-005453-4057qib7 5685 2 mofetil mofetil NNP cord-005453-4057qib7 5685 3 ( ( -LRB- cord-005453-4057qib7 5685 4 25 25 CD cord-005453-4057qib7 5685 5 % % NN cord-005453-4057qib7 5685 6 ) ) -RRB- cord-005453-4057qib7 5685 7 , , , cord-005453-4057qib7 5685 8 ATG ATG NNP cord-005453-4057qib7 5685 9 ( ( -LRB- cord-005453-4057qib7 5685 10 16 16 CD cord-005453-4057qib7 5685 11 % % NN cord-005453-4057qib7 5685 12 ) ) -RRB- cord-005453-4057qib7 5685 13 , , , cord-005453-4057qib7 5685 14 extracorporeal extracorporeal JJ cord-005453-4057qib7 5685 15 photophoresis photophoresis NN cord-005453-4057qib7 5685 16 ( ( -LRB- cord-005453-4057qib7 5685 17 13 13 CD cord-005453-4057qib7 5685 18 % % NN cord-005453-4057qib7 5685 19 ) ) -RRB- cord-005453-4057qib7 5685 20 , , , cord-005453-4057qib7 5685 21 tocilizumab tocilizumab NNP cord-005453-4057qib7 5685 22 ( ( -LRB- cord-005453-4057qib7 5685 23 13 13 CD cord-005453-4057qib7 5685 24 % % NN cord-005453-4057qib7 5685 25 ) ) -RRB- cord-005453-4057qib7 5685 26 , , , cord-005453-4057qib7 5685 27 etanercept etanercept NNP cord-005453-4057qib7 5685 28 ( ( -LRB- cord-005453-4057qib7 5685 29 9 9 CD cord-005453-4057qib7 5685 30 % % NN cord-005453-4057qib7 5685 31 ) ) -RRB- cord-005453-4057qib7 5685 32 , , , cord-005453-4057qib7 5685 33 and and CC cord-005453-4057qib7 5685 34 sirolimus sirolimus NNP cord-005453-4057qib7 5685 35 ( ( -LRB- cord-005453-4057qib7 5685 36 9 9 CD cord-005453-4057qib7 5685 37 % % NN cord-005453-4057qib7 5685 38 ) ) -RRB- cord-005453-4057qib7 5685 39 . . . cord-005453-4057qib7 5686 1 aGVHD aGVHD NNP cord-005453-4057qib7 5686 2 recurred recur VBD cord-005453-4057qib7 5686 3 in in IN cord-005453-4057qib7 5686 4 31 31 CD cord-005453-4057qib7 5686 5 % % NN cord-005453-4057qib7 5686 6 of of IN cord-005453-4057qib7 5686 7 patients patient NNS cord-005453-4057qib7 5686 8 and and CC cord-005453-4057qib7 5686 9 was be VBD cord-005453-4057qib7 5686 10 managed manage VBN cord-005453-4057qib7 5686 11 by by IN cord-005453-4057qib7 5686 12 increasing increase VBG cord-005453-4057qib7 5686 13 corticosteroid corticosteroid NN cord-005453-4057qib7 5686 14 dose dose NN cord-005453-4057qib7 5686 15 in in IN cord-005453-4057qib7 5686 16 70 70 CD cord-005453-4057qib7 5686 17 % % NN cord-005453-4057qib7 5686 18 of of IN cord-005453-4057qib7 5686 19 patients patient NNS cord-005453-4057qib7 5686 20 . . . cord-005453-4057qib7 5687 1 44 44 CD cord-005453-4057qib7 5687 2 % % NN cord-005453-4057qib7 5687 3 had have VBD cord-005453-4057qib7 5687 4 any any DT cord-005453-4057qib7 5687 5 infection infection NN cord-005453-4057qib7 5687 6 within within IN cord-005453-4057qib7 5687 7 first first JJ cord-005453-4057qib7 5687 8 100 100 CD cord-005453-4057qib7 5687 9 days day NNS cord-005453-4057qib7 5687 10 post post NN cord-005453-4057qib7 5687 11 - - JJ cord-005453-4057qib7 5687 12 HSCT HSCT NNP cord-005453-4057qib7 5687 13 . . . cord-005453-4057qib7 5688 1 Forty forty CD cord-005453-4057qib7 5688 2 patients patient NNS cord-005453-4057qib7 5688 3 ( ( -LRB- cord-005453-4057qib7 5688 4 63 63 CD cord-005453-4057qib7 5688 5 % % NN cord-005453-4057qib7 5688 6 ) ) -RRB- cord-005453-4057qib7 5688 7 required require VBN cord-005453-4057qib7 5688 8 hospital hospital NN cord-005453-4057qib7 5688 9 readmission(s readmission(s NNP cord-005453-4057qib7 5688 10 ) ) -RRB- cord-005453-4057qib7 5688 11 ; ; : cord-005453-4057qib7 5688 12 40 40 CD cord-005453-4057qib7 5688 13 % % NN cord-005453-4057qib7 5688 14 had have VBD cord-005453-4057qib7 5689 1 ≥2 ≥2 NNP cord-005453-4057qib7 5689 2 readmissions readmission NNS cord-005453-4057qib7 5689 3 within within IN cord-005453-4057qib7 5689 4 100 100 CD cord-005453-4057qib7 5689 5 days day NNS cord-005453-4057qib7 5689 6 post post NN cord-005453-4057qib7 5689 7 - - JJ cord-005453-4057qib7 5689 8 HSCT HSCT NNP cord-005453-4057qib7 5689 9 , , , cord-005453-4057qib7 5689 10 with with IN cord-005453-4057qib7 5689 11 a a DT cord-005453-4057qib7 5689 12 mean mean JJ cord-005453-4057qib7 5689 13 inpatient inpatient JJ cord-005453-4057qib7 5689 14 lengthof lengthof NN cord-005453-4057qib7 5689 15 - - HYPH cord-005453-4057qib7 5689 16 stay stay NN cord-005453-4057qib7 5689 17 of of IN cord-005453-4057qib7 5689 18 28 28 CD cord-005453-4057qib7 5689 19 days day NNS cord-005453-4057qib7 5689 20 . . . cord-005453-4057qib7 5690 1 Relapse relapse NN cord-005453-4057qib7 5690 2 of of IN cord-005453-4057qib7 5690 3 underlying underlie VBG cord-005453-4057qib7 5690 4 malignancy malignancy NN cord-005453-4057qib7 5690 5 was be VBD cord-005453-4057qib7 5690 6 reported report VBN cord-005453-4057qib7 5690 7 for for IN cord-005453-4057qib7 5690 8 13 13 CD cord-005453-4057qib7 5690 9 ( ( -LRB- cord-005453-4057qib7 5690 10 20 20 CD cord-005453-4057qib7 5690 11 % % NN cord-005453-4057qib7 5690 12 ) ) -RRB- cord-005453-4057qib7 5690 13 patients patient NNS cord-005453-4057qib7 5690 14 . . . cord-005453-4057qib7 5691 1 Two two CD cord-005453-4057qib7 5691 2 - - HYPH cord-005453-4057qib7 5691 3 thirds third NNS cord-005453-4057qib7 5691 4 ( ( -LRB- cord-005453-4057qib7 5691 5 66 66 CD cord-005453-4057qib7 5691 6 % % NN cord-005453-4057qib7 5691 7 , , , cord-005453-4057qib7 5691 8 n=40 n=40 JJ cord-005453-4057qib7 5691 9 ) ) -RRB- cord-005453-4057qib7 5691 10 patients patient NNS cord-005453-4057qib7 5691 11 died die VBD cord-005453-4057qib7 5691 12 at at IN cord-005453-4057qib7 5691 13 a a DT cord-005453-4057qib7 5691 14 median median NN cord-005453-4057qib7 5691 15 of of IN cord-005453-4057qib7 5691 16 87 87 CD cord-005453-4057qib7 5691 17 ( ( -LRB- cord-005453-4057qib7 5691 18 interquartile interquartile JJ cord-005453-4057qib7 5691 19 range range NN cord-005453-4057qib7 5691 20 ( ( -LRB- cord-005453-4057qib7 5691 21 IQR IQR NNP cord-005453-4057qib7 5691 22 ) ) -RRB- cord-005453-4057qib7 5691 23 : : : cord-005453-4057qib7 5691 24 44 44 CD cord-005453-4057qib7 5691 25 - - SYM cord-005453-4057qib7 5691 26 180 180 CD cord-005453-4057qib7 5691 27 ) ) -RRB- cord-005453-4057qib7 5691 28 days day NNS cord-005453-4057qib7 5691 29 from from IN cord-005453-4057qib7 5691 30 aGVHD aGVHD NNP cord-005453-4057qib7 5691 31 diagnosis diagnosis NN cord-005453-4057qib7 5691 32 ; ; : cord-005453-4057qib7 5691 33 a a DT cord-005453-4057qib7 5691 34 higher high JJR cord-005453-4057qib7 5691 35 proportion proportion NN cord-005453-4057qib7 5691 36 ( ( -LRB- cord-005453-4057qib7 5691 37 76 76 CD cord-005453-4057qib7 5691 38 % % NN cord-005453-4057qib7 5691 39 ) ) -RRB- cord-005453-4057qib7 5691 40 of of IN cord-005453-4057qib7 5691 41 patients patient NNS cord-005453-4057qib7 5691 42 with with IN cord-005453-4057qib7 5691 43 maximum maximum JJ cord-005453-4057qib7 5691 44 grade grade NN cord-005453-4057qib7 5691 45 III III NNP cord-005453-4057qib7 5691 46 - - HYPH cord-005453-4057qib7 5691 47 IV IV NNP cord-005453-4057qib7 5691 48 aGVHD aGVHD NNP cord-005453-4057qib7 5691 49 died die VBD cord-005453-4057qib7 5691 50 at at IN cord-005453-4057qib7 5691 51 a a DT cord-005453-4057qib7 5691 52 median median NN cord-005453-4057qib7 5691 53 of of IN cord-005453-4057qib7 5691 54 63 63 CD cord-005453-4057qib7 5691 55 ( ( -LRB- cord-005453-4057qib7 5691 56 IQR iqr NN cord-005453-4057qib7 5691 57 : : : cord-005453-4057qib7 5691 58 41.5 41.5 CD cord-005453-4057qib7 5691 59 - - SYM cord-005453-4057qib7 5691 60 186.5 186.5 CD cord-005453-4057qib7 5691 61 ) ) -RRB- cord-005453-4057qib7 5691 62 days day NNS cord-005453-4057qib7 5691 63 ; ; : cord-005453-4057qib7 5691 64 majority majority NN cord-005453-4057qib7 5691 65 ( ( -LRB- cord-005453-4057qib7 5691 66 81 81 CD cord-005453-4057qib7 5691 67 % % NN cord-005453-4057qib7 5691 68 ) ) -RRB- cord-005453-4057qib7 5691 69 of of IN cord-005453-4057qib7 5691 70 patients patient NNS cord-005453-4057qib7 5691 71 with with IN cord-005453-4057qib7 5691 72 lower low JJR cord-005453-4057qib7 5691 73 GI GI NNP cord-005453-4057qib7 5691 74 aGVHD aGVHD NNP cord-005453-4057qib7 5691 75 died die VBD cord-005453-4057qib7 5691 76 at at IN cord-005453-4057qib7 5691 77 a a DT cord-005453-4057qib7 5691 78 median median NN cord-005453-4057qib7 5691 79 of of IN cord-005453-4057qib7 5691 80 68.5 68.5 CD cord-005453-4057qib7 5691 81 ( ( -LRB- cord-005453-4057qib7 5691 82 IQR IQR NNP cord-005453-4057qib7 5691 83 : : : cord-005453-4057qib7 5691 84 44 44 CD cord-005453-4057qib7 5691 85 - - SYM cord-005453-4057qib7 5691 86 137 137 CD cord-005453-4057qib7 5691 87 ) ) -RRB- cord-005453-4057qib7 5691 88 days day NNS cord-005453-4057qib7 5691 89 . . . cord-005453-4057qib7 5692 1 Conclusions conclusion NNS cord-005453-4057qib7 5692 2 : : : cord-005453-4057qib7 5693 1 A a DT cord-005453-4057qib7 5693 2 majority majority NN cord-005453-4057qib7 5693 3 of of IN cord-005453-4057qib7 5693 4 patients patient NNS cord-005453-4057qib7 5693 5 with with IN cord-005453-4057qib7 5693 6 aGVHD aGVHD NNP cord-005453-4057qib7 5693 7 who who WP cord-005453-4057qib7 5693 8 had have VBD cord-005453-4057qib7 5693 9 suboptimal suboptimal JJ cord-005453-4057qib7 5693 10 response response NN cord-005453-4057qib7 5693 11 to to IN cord-005453-4057qib7 5693 12 systemic systemic JJ cord-005453-4057qib7 5693 13 corticosteroids corticosteroid NNS cord-005453-4057qib7 5693 14 had have VBD cord-005453-4057qib7 5693 15 severe severe JJ cord-005453-4057qib7 5693 16 and and CC cord-005453-4057qib7 5693 17 rapidly rapidly RB cord-005453-4057qib7 5693 18 progressing progress VBG cord-005453-4057qib7 5693 19 disease disease NN cord-005453-4057qib7 5693 20 and and CC cord-005453-4057qib7 5693 21 resulted result VBD cord-005453-4057qib7 5693 22 in in IN cord-005453-4057qib7 5693 23 a a DT cord-005453-4057qib7 5693 24 high high JJ cord-005453-4057qib7 5693 25 mortality mortality NN cord-005453-4057qib7 5693 26 rate rate NN cord-005453-4057qib7 5693 27 ( ( -LRB- cord-005453-4057qib7 5693 28 66 66 CD cord-005453-4057qib7 5693 29 % % NN cord-005453-4057qib7 5693 30 ) ) -RRB- cord-005453-4057qib7 5693 31 ; ; : cord-005453-4057qib7 5693 32 progression progression NN cord-005453-4057qib7 5693 33 was be VBD cord-005453-4057qib7 5693 34 more more RBR cord-005453-4057qib7 5693 35 rapid rapid JJ cord-005453-4057qib7 5693 36 and and CC cord-005453-4057qib7 5693 37 mortality mortality NN cord-005453-4057qib7 5693 38 increased increase VBD cord-005453-4057qib7 5693 39 for for IN cord-005453-4057qib7 5693 40 patients patient NNS cord-005453-4057qib7 5693 41 with with IN cord-005453-4057qib7 5693 42 lower low JJR cord-005453-4057qib7 5693 43 GI GI NNP cord-005453-4057qib7 5693 44 involvement involvement NN cord-005453-4057qib7 5693 45 . . . cord-005453-4057qib7 5694 1 Most Most JJS cord-005453-4057qib7 5694 2 patients patient NNS cord-005453-4057qib7 5694 3 required require VBD cord-005453-4057qib7 5694 4 readmission readmission NN cord-005453-4057qib7 5694 5 to to IN cord-005453-4057qib7 5694 6 the the DT cord-005453-4057qib7 5694 7 hospital hospital NN cord-005453-4057qib7 5694 8 with with IN cord-005453-4057qib7 5694 9 extended extended JJ cord-005453-4057qib7 5694 10 length length NN cord-005453-4057qib7 5694 11 - - HYPH cord-005453-4057qib7 5694 12 of of IN cord-005453-4057qib7 5694 13 - - HYPH cord-005453-4057qib7 5694 14 stay stay NN cord-005453-4057qib7 5694 15 . . . cord-005453-4057qib7 5695 1 An an DT cord-005453-4057qib7 5695 2 urgent urgent JJ cord-005453-4057qib7 5695 3 need need NN cord-005453-4057qib7 5695 4 exists exist VBZ cord-005453-4057qib7 5695 5 for for IN cord-005453-4057qib7 5695 6 effective effective JJ cord-005453-4057qib7 5695 7 and and CC cord-005453-4057qib7 5695 8 tolerable tolerable JJ cord-005453-4057qib7 5695 9 therapies therapy NNS cord-005453-4057qib7 5695 10 that that WDT cord-005453-4057qib7 5695 11 quickly quickly RB cord-005453-4057qib7 5695 12 resolve resolve VB cord-005453-4057qib7 5695 13 life life NN cord-005453-4057qib7 5695 14 - - HYPH cord-005453-4057qib7 5695 15 threatening threaten VBG cord-005453-4057qib7 5695 16 aGVHD agvhd NN cord-005453-4057qib7 5695 17 in in IN cord-005453-4057qib7 5695 18 early early JJ cord-005453-4057qib7 5695 19 stages stage NNS cord-005453-4057qib7 5695 20 of of IN cord-005453-4057qib7 5695 21 disease disease NN cord-005453-4057qib7 5695 22 . . . cord-005453-4057qib7 5696 1 Disclosure disclosure NN cord-005453-4057qib7 5696 2 Results result NNS cord-005453-4057qib7 5696 3 : : : cord-005453-4057qib7 5697 1 Median median JJ cord-005453-4057qib7 5697 2 time time NN cord-005453-4057qib7 5697 3 to to IN cord-005453-4057qib7 5697 4 onset onset NN cord-005453-4057qib7 5697 5 of of IN cord-005453-4057qib7 5697 6 BO BO NNP cord-005453-4057qib7 5697 7 from from IN cord-005453-4057qib7 5697 8 alloHCT alloHCT NNP cord-005453-4057qib7 5697 9 was be VBD cord-005453-4057qib7 5697 10 6.9 6.9 CD cord-005453-4057qib7 5697 11 months month NNS cord-005453-4057qib7 5698 1 ( ( -LRB- cord-005453-4057qib7 5698 2 range range VBP cord-005453-4057qib7 5698 3 0.6 0.6 CD cord-005453-4057qib7 5698 4 - - HYPH cord-005453-4057qib7 5698 5 31.2 31.2 CD cord-005453-4057qib7 5698 6 ) ) -RRB- cord-005453-4057qib7 5698 7 . . . cord-005453-4057qib7 5699 1 Previous previous JJ cord-005453-4057qib7 5699 2 acute acute JJ cord-005453-4057qib7 5699 3 GVHD GVHD NNP cord-005453-4057qib7 5699 4 in in IN cord-005453-4057qib7 5699 5 52.2 52.2 CD cord-005453-4057qib7 5699 6 % % NN cord-005453-4057qib7 5700 1 ( ( -LRB- cord-005453-4057qib7 5700 2 n n NN cord-005453-4057qib7 5700 3 = = SYM cord-005453-4057qib7 5700 4 24 24 CD cord-005453-4057qib7 5700 5 ) ) -RRB- cord-005453-4057qib7 5700 6 [ [ -LRB- cord-005453-4057qib7 5700 7 grades grade NNS cord-005453-4057qib7 5700 8 III III NNP cord-005453-4057qib7 5700 9 - - HYPH cord-005453-4057qib7 5700 10 IV IV NNP cord-005453-4057qib7 5700 11 29.2 29.2 CD cord-005453-4057qib7 5700 12 % % NN cord-005453-4057qib7 5700 13 ( ( -LRB- cord-005453-4057qib7 5700 14 n n NN cord-005453-4057qib7 5700 15 = = SYM cord-005453-4057qib7 5700 16 7 7 CD cord-005453-4057qib7 5700 17 ) ) -RRB- cord-005453-4057qib7 5700 18 ] ] -RRB- cord-005453-4057qib7 5700 19 . . . cord-005453-4057qib7 5701 1 In in IN cord-005453-4057qib7 5701 2 23.9 23.9 CD cord-005453-4057qib7 5701 3 % % NN cord-005453-4057qib7 5701 4 ( ( -LRB- cord-005453-4057qib7 5701 5 n n NN cord-005453-4057qib7 5701 6 = = SYM cord-005453-4057qib7 5701 7 11 11 CD cord-005453-4057qib7 5701 8 ) ) -RRB- cord-005453-4057qib7 5701 9 cGVHD cGVHD NNP cord-005453-4057qib7 5701 10 had have VBD cord-005453-4057qib7 5701 11 exclusive exclusive JJ cord-005453-4057qib7 5701 12 lung lung NN cord-005453-4057qib7 5701 13 involvement involvement NN cord-005453-4057qib7 5701 14 , , , cord-005453-4057qib7 5701 15 while while IN cord-005453-4057qib7 5701 16 the the DT cord-005453-4057qib7 5701 17 other other JJ cord-005453-4057qib7 5701 18 35 35 CD cord-005453-4057qib7 5701 19 patients patient NNS cord-005453-4057qib7 5701 20 ( ( -LRB- cord-005453-4057qib7 5701 21 76 76 CD cord-005453-4057qib7 5701 22 % % NN cord-005453-4057qib7 5701 23 ) ) -RRB- cord-005453-4057qib7 5701 24 had have VBD cord-005453-4057qib7 5701 25 other other JJ cord-005453-4057qib7 5701 26 organs organ NNS cord-005453-4057qib7 5701 27 affected affect VBN cord-005453-4057qib7 5701 28 . . . cord-005453-4057qib7 5702 1 At at IN cord-005453-4057qib7 5702 2 diagnosis diagnosis NN cord-005453-4057qib7 5702 3 of of IN cord-005453-4057qib7 5702 4 BO BO NNP cord-005453-4057qib7 5702 5 , , , cord-005453-4057qib7 5702 6 69.6 69.6 CD cord-005453-4057qib7 5702 7 % % NN cord-005453-4057qib7 5702 8 ( ( -LRB- cord-005453-4057qib7 5702 9 n n NN cord-005453-4057qib7 5702 10 = = SYM cord-005453-4057qib7 5702 11 32 32 CD cord-005453-4057qib7 5702 12 ) ) -RRB- cord-005453-4057qib7 5702 13 were be VBD cord-005453-4057qib7 5702 14 under under IN cord-005453-4057qib7 5702 15 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 5702 16 treatment treatment NN cord-005453-4057qib7 5702 17 . . . cord-005453-4057qib7 5703 1 32.6 32.6 CD cord-005453-4057qib7 5703 2 % % NN cord-005453-4057qib7 5703 3 ( ( -LRB- cord-005453-4057qib7 5703 4 n=15 n=15 NNP cord-005453-4057qib7 5703 5 ) ) -RRB- cord-005453-4057qib7 5703 6 of of IN cord-005453-4057qib7 5703 7 patients patient NNS cord-005453-4057qib7 5703 8 with with IN cord-005453-4057qib7 5703 9 BO BO NNP cord-005453-4057qib7 5703 10 received receive VBD cord-005453-4057qib7 5703 11 ECP ECP NNP cord-005453-4057qib7 5703 12 as as IN cord-005453-4057qib7 5703 13 second second JJ cord-005453-4057qib7 5703 14 - - HYPH cord-005453-4057qib7 5703 15 line line NN cord-005453-4057qib7 5703 16 treatment treatment NN cord-005453-4057qib7 5703 17 . . . cord-005453-4057qib7 5704 1 Median median JJ cord-005453-4057qib7 5704 2 duration duration NN cord-005453-4057qib7 5704 3 of of IN cord-005453-4057qib7 5704 4 treatment treatment NN cord-005453-4057qib7 5704 5 was be VBD cord-005453-4057qib7 5704 6 22 22 CD cord-005453-4057qib7 5704 7 months month NNS cord-005453-4057qib7 5704 8 ( ( -LRB- cord-005453-4057qib7 5704 9 1.5 1.5 CD cord-005453-4057qib7 5704 10 - - SYM cord-005453-4057qib7 5704 11 36.8 36.8 CD cord-005453-4057qib7 5704 12 ) ) -RRB- cord-005453-4057qib7 5704 13 and and CC cord-005453-4057qib7 5704 14 time time NN cord-005453-4057qib7 5704 15 to to TO cord-005453-4057qib7 5704 16 response response VB cord-005453-4057qib7 5704 17 9.9 9.9 CD cord-005453-4057qib7 5704 18 months month NNS cord-005453-4057qib7 5704 19 ( ( -LRB- cord-005453-4057qib7 5704 20 1.9 1.9 CD cord-005453-4057qib7 5704 21 - - SYM cord-005453-4057qib7 5704 22 30.2 30.2 CD cord-005453-4057qib7 5704 23 ) ) -RRB- cord-005453-4057qib7 5704 24 . . . cord-005453-4057qib7 5705 1 Median median NN cord-005453-4057qib7 5705 2 of of IN cord-005453-4057qib7 5705 3 sessions session NNS cord-005453-4057qib7 5705 4 was be VBD cord-005453-4057qib7 5705 5 40 40 CD cord-005453-4057qib7 5705 6 ( ( -LRB- cord-005453-4057qib7 5705 7 4 4 CD cord-005453-4057qib7 5705 8 - - SYM cord-005453-4057qib7 5705 9 108 108 CD cord-005453-4057qib7 5705 10 ) ) -RRB- cord-005453-4057qib7 5705 11 . . . cord-005453-4057qib7 5706 1 Evaluation evaluation NN cord-005453-4057qib7 5706 2 of of IN cord-005453-4057qib7 5706 3 response response NN cord-005453-4057qib7 5706 4 was be VBD cord-005453-4057qib7 5706 5 based base VBN cord-005453-4057qib7 5706 6 on on IN cord-005453-4057qib7 5706 7 the the DT cord-005453-4057qib7 5706 8 evolution evolution NN cord-005453-4057qib7 5706 9 of of IN cord-005453-4057qib7 5706 10 FEV1 FEV1 NNP cord-005453-4057qib7 5706 11 measurement measurement NN cord-005453-4057qib7 5706 12 : : : cord-005453-4057qib7 5706 13 26.6 26.6 CD cord-005453-4057qib7 5706 14 % % NN cord-005453-4057qib7 5706 15 ( ( -LRB- cord-005453-4057qib7 5706 16 n n NN cord-005453-4057qib7 5706 17 = = SYM cord-005453-4057qib7 5706 18 4 4 CD cord-005453-4057qib7 5706 19 ) ) -RRB- cord-005453-4057qib7 5706 20 complete complete JJ cord-005453-4057qib7 5706 21 response response NN cord-005453-4057qib7 5706 22 ; ; : cord-005453-4057qib7 5706 23 40 40 CD cord-005453-4057qib7 5706 24 % % NN cord-005453-4057qib7 5706 25 ( ( -LRB- cord-005453-4057qib7 5706 26 n n NN cord-005453-4057qib7 5706 27 = = SYM cord-005453-4057qib7 5706 28 6 6 CD cord-005453-4057qib7 5706 29 ) ) -RRB- cord-005453-4057qib7 5706 30 partial partial JJ cord-005453-4057qib7 5706 31 response response NN cord-005453-4057qib7 5706 32 and and CC cord-005453-4057qib7 5706 33 20 20 CD cord-005453-4057qib7 5706 34 % % NN cord-005453-4057qib7 5706 35 ( ( -LRB- cord-005453-4057qib7 5706 36 n n NN cord-005453-4057qib7 5706 37 = = SYM cord-005453-4057qib7 5706 38 3 3 CD cord-005453-4057qib7 5706 39 ) ) -RRB- cord-005453-4057qib7 5706 40 stable stable JJ cord-005453-4057qib7 5706 41 disease disease NN cord-005453-4057qib7 5706 42 . . . cord-005453-4057qib7 5707 1 One one CD cord-005453-4057qib7 5707 2 patient patient NN cord-005453-4057qib7 5707 3 did do VBD cord-005453-4057qib7 5707 4 not not RB cord-005453-4057qib7 5707 5 get get VB cord-005453-4057qib7 5707 6 any any DT cord-005453-4057qib7 5707 7 response response NN cord-005453-4057qib7 5707 8 and and CC cord-005453-4057qib7 5707 9 another another DT cord-005453-4057qib7 5707 10 was be VBD cord-005453-4057qib7 5707 11 not not RB cord-005453-4057qib7 5707 12 evaluable evaluable JJ cord-005453-4057qib7 5707 13 . . . cord-005453-4057qib7 5708 1 66.6 66.6 CD cord-005453-4057qib7 5708 2 % % NN cord-005453-4057qib7 5708 3 of of IN cord-005453-4057qib7 5708 4 patients patient NNS cord-005453-4057qib7 5708 5 ( ( -LRB- cord-005453-4057qib7 5708 6 n n NN cord-005453-4057qib7 5708 7 = = SYM cord-005453-4057qib7 5708 8 10 10 CD cord-005453-4057qib7 5708 9 ) ) -RRB- cord-005453-4057qib7 5708 10 could could MD cord-005453-4057qib7 5708 11 reduce reduce VB cord-005453-4057qib7 5708 12 immunosuppression immunosuppression NN cord-005453-4057qib7 5708 13 , , , cord-005453-4057qib7 5708 14 and and CC cord-005453-4057qib7 5708 15 in in IN cord-005453-4057qib7 5708 16 one one CD cord-005453-4057qib7 5708 17 case case NN cord-005453-4057qib7 5708 18 it -PRON- PRP cord-005453-4057qib7 5708 19 was be VBD cord-005453-4057qib7 5708 20 completely completely RB cord-005453-4057qib7 5708 21 discontinued discontinue VBN cord-005453-4057qib7 5708 22 . . . cord-005453-4057qib7 5709 1 There there EX cord-005453-4057qib7 5709 2 is be VBZ cord-005453-4057qib7 5709 3 a a DT cord-005453-4057qib7 5709 4 trend trend NN cord-005453-4057qib7 5709 5 for for IN cord-005453-4057qib7 5709 6 early early JJ cord-005453-4057qib7 5709 7 separation separation NN cord-005453-4057qib7 5709 8 between between IN cord-005453-4057qib7 5709 9 survival survival NN cord-005453-4057qib7 5709 10 curves curve NNS cord-005453-4057qib7 5709 11 in in IN cord-005453-4057qib7 5709 12 favor favor NN cord-005453-4057qib7 5709 13 of of IN cord-005453-4057qib7 5709 14 ECP ECP NNP cord-005453-4057qib7 5709 15 ( ( -LRB- cord-005453-4057qib7 5709 16 Figure figure NN cord-005453-4057qib7 5709 17 1 1 CD cord-005453-4057qib7 5709 18 ) ) -RRB- cord-005453-4057qib7 5709 19 . . . cord-005453-4057qib7 5710 1 One one CD cord-005453-4057qib7 5710 2 patient patient NN cord-005453-4057qib7 5710 3 had have VBD cord-005453-4057qib7 5710 4 sepsis sepsis NN cord-005453-4057qib7 5710 5 secondary secondary JJ cord-005453-4057qib7 5710 6 to to IN cord-005453-4057qib7 5710 7 central central JJ cord-005453-4057qib7 5710 8 venous venous JJ cord-005453-4057qib7 5710 9 catheter catheter NN cord-005453-4057qib7 5710 10 infection infection NN cord-005453-4057qib7 5710 11 as as IN cord-005453-4057qib7 5710 12 complication complication NN cord-005453-4057qib7 5710 13 related relate VBN cord-005453-4057qib7 5710 14 to to IN cord-005453-4057qib7 5710 15 ECP ECP NNP cord-005453-4057qib7 5710 16 . . . cord-005453-4057qib7 5711 1 Conclusions conclusion NNS cord-005453-4057qib7 5711 2 : : : cord-005453-4057qib7 5712 1 ECP ECP NNP cord-005453-4057qib7 5712 2 has have VBZ cord-005453-4057qib7 5712 3 emerged emerge VBN cord-005453-4057qib7 5712 4 as as IN cord-005453-4057qib7 5712 5 a a DT cord-005453-4057qib7 5712 6 promising promising JJ cord-005453-4057qib7 5712 7 treatment treatment NN cord-005453-4057qib7 5712 8 for for IN cord-005453-4057qib7 5712 9 BO BO NNP cord-005453-4057qib7 5712 10 after after IN cord-005453-4057qib7 5712 11 alloHCT alloHCT NNP cord-005453-4057qib7 5712 12 . . . cord-005453-4057qib7 5713 1 In in IN cord-005453-4057qib7 5713 2 our -PRON- PRP$ cord-005453-4057qib7 5713 3 experience experience NN cord-005453-4057qib7 5713 4 , , , cord-005453-4057qib7 5713 5 ECP ECP NNP cord-005453-4057qib7 5713 6 was be VBD cord-005453-4057qib7 5713 7 effective effective JJ cord-005453-4057qib7 5713 8 to to TO cord-005453-4057qib7 5713 9 stabilize stabilize VB cord-005453-4057qib7 5713 10 or or CC cord-005453-4057qib7 5713 11 improve improve VB cord-005453-4057qib7 5713 12 the the DT cord-005453-4057qib7 5713 13 disease disease NN cord-005453-4057qib7 5713 14 in in IN cord-005453-4057qib7 5713 15 many many JJ cord-005453-4057qib7 5713 16 patients patient NNS cord-005453-4057qib7 5713 17 and and CC cord-005453-4057qib7 5713 18 allowed allow VBN cord-005453-4057qib7 5713 19 to to TO cord-005453-4057qib7 5713 20 taper taper VB cord-005453-4057qib7 5713 21 esteroids esteroid NNS cord-005453-4057qib7 5713 22 with with IN cord-005453-4057qib7 5713 23 minimal minimal JJ cord-005453-4057qib7 5713 24 associated associate VBN cord-005453-4057qib7 5713 25 complications complication NNS cord-005453-4057qib7 5713 26 . . . cord-005453-4057qib7 5714 1 However however RB cord-005453-4057qib7 5714 2 , , , cord-005453-4057qib7 5714 3 prospective prospective JJ cord-005453-4057qib7 5714 4 studies study NNS cord-005453-4057qib7 5714 5 and and CC cord-005453-4057qib7 5714 6 longer long RBR cord-005453-4057qib7 5714 7 follow follow VB cord-005453-4057qib7 5714 8 - - HYPH cord-005453-4057qib7 5714 9 up up NN cord-005453-4057qib7 5714 10 are be VBP cord-005453-4057qib7 5714 11 needed need VBN cord-005453-4057qib7 5714 12 to to TO cord-005453-4057qib7 5714 13 support support VB cord-005453-4057qib7 5714 14 these these DT cord-005453-4057qib7 5714 15 findings finding NNS cord-005453-4057qib7 5714 16 . . . cord-005453-4057qib7 5715 1 Disclosure disclosure NN cord-005453-4057qib7 5715 2 : : : cord-005453-4057qib7 5715 3 Nothing nothing NN cord-005453-4057qib7 5715 4 to to TO cord-005453-4057qib7 5715 5 declare declare VB cord-005453-4057qib7 5715 6 Background background NN cord-005453-4057qib7 5715 7 : : : cord-005453-4057qib7 5716 1 The the DT cord-005453-4057qib7 5716 2 key key JJ cord-005453-4057qib7 5716 3 role role NN cord-005453-4057qib7 5716 4 of of IN cord-005453-4057qib7 5716 5 IL-6 IL-6 NNP cord-005453-4057qib7 5716 6 signaling signal VBG cord-005453-4057qib7 5716 7 in in IN cord-005453-4057qib7 5716 8 acute acute JJ cord-005453-4057qib7 5716 9 graft graft NN cord-005453-4057qib7 5716 10 vs. vs. IN cord-005453-4057qib7 5716 11 host host NN cord-005453-4057qib7 5716 12 disease disease NN cord-005453-4057qib7 5716 13 ( ( -LRB- cord-005453-4057qib7 5716 14 aGVHD aGVHD NNP cord-005453-4057qib7 5716 15 ) ) -RRB- cord-005453-4057qib7 5716 16 and and CC cord-005453-4057qib7 5716 17 cytokine cytokine NN cord-005453-4057qib7 5716 18 release release NN cord-005453-4057qib7 5716 19 syndrome syndrome NN cord-005453-4057qib7 5716 20 ( ( -LRB- cord-005453-4057qib7 5716 21 CRS CRS NNP cord-005453-4057qib7 5716 22 ) ) -RRB- cord-005453-4057qib7 5716 23 has have VBZ cord-005453-4057qib7 5716 24 evoked evoke VBN cord-005453-4057qib7 5716 25 growing grow VBG cord-005453-4057qib7 5716 26 use use NN cord-005453-4057qib7 5716 27 of of IN cord-005453-4057qib7 5716 28 tocilizumab tocilizumab NNP cord-005453-4057qib7 5716 29 , , , cord-005453-4057qib7 5716 30 an an DT cord-005453-4057qib7 5716 31 anti anti JJ cord-005453-4057qib7 5716 32 - - JJ cord-005453-4057qib7 5716 33 IL6 il6 JJ cord-005453-4057qib7 5716 34 receptor receptor NN cord-005453-4057qib7 5716 35 ( ( -LRB- cord-005453-4057qib7 5716 36 IL6-R il6-r NN cord-005453-4057qib7 5716 37 ) ) -RRB- cord-005453-4057qib7 5716 38 antibody antibody NN cord-005453-4057qib7 5716 39 , , , cord-005453-4057qib7 5716 40 in in IN cord-005453-4057qib7 5716 41 these these DT cord-005453-4057qib7 5716 42 settings setting NNS cord-005453-4057qib7 5716 43 . . . cord-005453-4057qib7 5717 1 Apart apart RB cord-005453-4057qib7 5717 2 from from IN cord-005453-4057qib7 5717 3 regulation regulation NN cord-005453-4057qib7 5717 4 of of IN cord-005453-4057qib7 5717 5 T T NNP cord-005453-4057qib7 5717 6 - - HYPH cord-005453-4057qib7 5717 7 and and CC cord-005453-4057qib7 5717 8 B b NN cord-005453-4057qib7 5717 9 - - HYPH cord-005453-4057qib7 5717 10 cell cell NN cord-005453-4057qib7 5717 11 differentiation differentiation NN cord-005453-4057qib7 5717 12 , , , cord-005453-4057qib7 5717 13 immune immune JJ cord-005453-4057qib7 5717 14 cells cell NNS cord-005453-4057qib7 5717 15 migration migration NN cord-005453-4057qib7 5717 16 to to IN cord-005453-4057qib7 5717 17 inflammatory inflammatory JJ cord-005453-4057qib7 5717 18 sites site NNS cord-005453-4057qib7 5717 19 and and CC cord-005453-4057qib7 5717 20 T t NN cord-005453-4057qib7 5717 21 - - HYPH cord-005453-4057qib7 5717 22 cell cell NN cord-005453-4057qib7 5717 23 recruitment recruitment NN cord-005453-4057qib7 5717 24 , , , cord-005453-4057qib7 5717 25 IL-6 IL-6 NNP cord-005453-4057qib7 5717 26 complex complex NN cord-005453-4057qib7 5717 27 with with IN cord-005453-4057qib7 5717 28 IL6-R il6-r NN cord-005453-4057qib7 5718 1 through through IN cord-005453-4057qib7 5718 2 gp130 gp130 NNS cord-005453-4057qib7 5719 1 upregulates upregulate VBZ cord-005453-4057qib7 5719 2 production production NN cord-005453-4057qib7 5719 3 of of IN cord-005453-4057qib7 5719 4 fibrinogen fibrinogen NN cord-005453-4057qib7 5719 5 ( ( -LRB- cord-005453-4057qib7 5719 6 Fg Fg NNP cord-005453-4057qib7 5719 7 ) ) -RRB- cord-005453-4057qib7 5719 8 and and CC cord-005453-4057qib7 5719 9 other other JJ cord-005453-4057qib7 5719 10 acute acute JJ cord-005453-4057qib7 5719 11 phase phase NN cord-005453-4057qib7 5719 12 proteins protein NNS cord-005453-4057qib7 5719 13 , , , cord-005453-4057qib7 5719 14 including include VBG cord-005453-4057qib7 5719 15 C c NN cord-005453-4057qib7 5719 16 - - HYPH cord-005453-4057qib7 5719 17 reactive reactive JJ cord-005453-4057qib7 5719 18 protein protein NN cord-005453-4057qib7 5719 19 ( ( -LRB- cord-005453-4057qib7 5719 20 CRP CRP NNP cord-005453-4057qib7 5719 21 ) ) -RRB- cord-005453-4057qib7 5719 22 . . . cord-005453-4057qib7 5720 1 Methods method NNS cord-005453-4057qib7 5720 2 : : : cord-005453-4057qib7 5721 1 We -PRON- PRP cord-005453-4057qib7 5721 2 retrospectively retrospectively RB cord-005453-4057qib7 5721 3 analyzed analyze VBD cord-005453-4057qib7 5721 4 data datum NNS cord-005453-4057qib7 5721 5 of of IN cord-005453-4057qib7 5721 6 7 7 CD cord-005453-4057qib7 5721 7 patients patient NNS cord-005453-4057qib7 5721 8 treated treat VBN cord-005453-4057qib7 5721 9 with with IN cord-005453-4057qib7 5721 10 tocilizumab tocilizumab NNP cord-005453-4057qib7 5721 11 ( ( -LRB- cord-005453-4057qib7 5721 12 8mg 8mg NNP cord-005453-4057qib7 5721 13 / / SYM cord-005453-4057qib7 5721 14 kg kg NN cord-005453-4057qib7 5721 15 ) ) -RRB- cord-005453-4057qib7 5721 16 due due IN cord-005453-4057qib7 5721 17 to to IN cord-005453-4057qib7 5721 18 steroid steroid NN cord-005453-4057qib7 5721 19 - - HYPH cord-005453-4057qib7 5721 20 refractory refractory JJ cord-005453-4057qib7 5721 21 ( ( -LRB- cord-005453-4057qib7 5721 22 SR SR NNP cord-005453-4057qib7 5721 23 ) ) -RRB- cord-005453-4057qib7 5721 24 aGvHD agvhd NN cord-005453-4057qib7 5721 25 and and CC cord-005453-4057qib7 5721 26 4 4 CD cord-005453-4057qib7 5721 27 patients patient NNS cord-005453-4057qib7 5721 28 because because IN cord-005453-4057qib7 5721 29 of of IN cord-005453-4057qib7 5721 30 CRS CRS NNP cord-005453-4057qib7 5721 31 . . . cord-005453-4057qib7 5722 1 Median median JJ cord-005453-4057qib7 5722 2 age age NN cord-005453-4057qib7 5722 3 was be VBD cord-005453-4057qib7 5722 4 37 37 CD cord-005453-4057qib7 5722 5 and and CC cord-005453-4057qib7 5722 6 47 47 CD cord-005453-4057qib7 5722 7 years year NNS cord-005453-4057qib7 5722 8 , , , cord-005453-4057qib7 5722 9 respectively respectively RB cord-005453-4057qib7 5722 10 . . . cord-005453-4057qib7 5723 1 Seven seven CD cord-005453-4057qib7 5723 2 patients patient NNS cord-005453-4057qib7 5723 3 were be VBD cord-005453-4057qib7 5723 4 transplanted transplant VBN cord-005453-4057qib7 5723 5 from from IN cord-005453-4057qib7 5723 6 unrelated unrelated JJ cord-005453-4057qib7 5723 7 donors donor NNS cord-005453-4057qib7 5723 8 ( ( -LRB- cord-005453-4057qib7 5723 9 MUD mud NN cord-005453-4057qib7 5723 10 / / SYM cord-005453-4057qib7 5723 11 MMUD MMUD NNP cord-005453-4057qib7 5723 12 ) ) -RRB- cord-005453-4057qib7 5723 13 and and CC cord-005453-4057qib7 5723 14 4 4 CD cord-005453-4057qib7 5723 15 from from IN cord-005453-4057qib7 5723 16 sibling sibling NN cord-005453-4057qib7 5723 17 donors donor NNS cord-005453-4057qib7 5723 18 . . . cord-005453-4057qib7 5724 1 Eight eight CD cord-005453-4057qib7 5724 2 patients patient NNS cord-005453-4057qib7 5724 3 received receive VBD cord-005453-4057qib7 5724 4 myeloablative myeloablative NNP cord-005453-4057qib7 5724 5 and and CC cord-005453-4057qib7 5724 6 3 3 CD cord-005453-4057qib7 5724 7 reduced reduced JJ cord-005453-4057qib7 5724 8 intensity intensity NN cord-005453-4057qib7 5724 9 conditioning conditioning NN cord-005453-4057qib7 5724 10 regimen regimen NN cord-005453-4057qib7 5724 11 . . . cord-005453-4057qib7 5725 1 Analyzed analyze VBN cord-005453-4057qib7 5725 2 data datum NNS cord-005453-4057qib7 5725 3 included include VBD cord-005453-4057qib7 5725 4 concentrations concentration NNS cord-005453-4057qib7 5725 5 of of IN cord-005453-4057qib7 5725 6 Fg Fg NNP cord-005453-4057qib7 5725 7 , , , cord-005453-4057qib7 5725 8 CRP CRP NNP cord-005453-4057qib7 5725 9 , , , cord-005453-4057qib7 5725 10 an an DT cord-005453-4057qib7 5725 11 incidence incidence NN cord-005453-4057qib7 5725 12 of of IN cord-005453-4057qib7 5725 13 infections infection NNS cord-005453-4057qib7 5725 14 at at IN cord-005453-4057qib7 5725 15 tocilizumab tocilizumab NNP cord-005453-4057qib7 5725 16 administration administration NN cord-005453-4057qib7 5725 17 and and CC cord-005453-4057qib7 5725 18 in in IN cord-005453-4057qib7 5725 19 weeks week NNS cord-005453-4057qib7 5725 20 following follow VBG cord-005453-4057qib7 5725 21 the the DT cord-005453-4057qib7 5725 22 infusion infusion NN cord-005453-4057qib7 5725 23 . . . cord-005453-4057qib7 5726 1 Results result NNS cord-005453-4057qib7 5726 2 : : : cord-005453-4057qib7 5727 1 Stage stage NN cord-005453-4057qib7 5727 2 II II NNP cord-005453-4057qib7 5727 3 aGvHD agvhd NN cord-005453-4057qib7 5727 4 was be VBD cord-005453-4057qib7 5727 5 diagnosed diagnose VBN cord-005453-4057qib7 5727 6 in in IN cord-005453-4057qib7 5727 7 1 1 CD cord-005453-4057qib7 5727 8 patient patient NN cord-005453-4057qib7 5727 9 , , , cord-005453-4057qib7 5727 10 stage stage NN cord-005453-4057qib7 5727 11 III iii CD cord-005453-4057qib7 5727 12 in in IN cord-005453-4057qib7 5727 13 4 4 CD cord-005453-4057qib7 5727 14 , , , cord-005453-4057qib7 5727 15 and and CC cord-005453-4057qib7 5727 16 stage stage NN cord-005453-4057qib7 5727 17 IV IV NNP cord-005453-4057qib7 5727 18 in in IN cord-005453-4057qib7 5727 19 2 2 CD cord-005453-4057qib7 5727 20 patients patient NNS cord-005453-4057qib7 5727 21 . . . cord-005453-4057qib7 5728 1 Involvement involvement NN cord-005453-4057qib7 5728 2 of of IN cord-005453-4057qib7 5728 3 the the DT cord-005453-4057qib7 5728 4 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 5728 5 tract tract NN cord-005453-4057qib7 5728 6 ( ( -LRB- cord-005453-4057qib7 5728 7 GI GI NNP cord-005453-4057qib7 5728 8 ) ) -RRB- cord-005453-4057qib7 5728 9 was be VBD cord-005453-4057qib7 5728 10 observed observe VBN cord-005453-4057qib7 5728 11 in in IN cord-005453-4057qib7 5728 12 85 85 CD cord-005453-4057qib7 5728 13 % % NN cord-005453-4057qib7 5728 14 of of IN cord-005453-4057qib7 5728 15 cases case NNS cord-005453-4057qib7 5728 16 . . . cord-005453-4057qib7 5729 1 The the DT cord-005453-4057qib7 5729 2 median median JJ cord-005453-4057qib7 5729 3 Fg Fg NNP cord-005453-4057qib7 5729 4 concentration concentration NN cord-005453-4057qib7 5729 5 before before IN cord-005453-4057qib7 5729 6 tocilizumab tocilizumab NNP cord-005453-4057qib7 5729 7 administration administration NN cord-005453-4057qib7 5729 8 was be VBD cord-005453-4057qib7 5729 9 2.56 2.56 CD cord-005453-4057qib7 5729 10 g g NN cord-005453-4057qib7 5729 11 / / SYM cord-005453-4057qib7 5729 12 l l NN cord-005453-4057qib7 5729 13 ( ( -LRB- cord-005453-4057qib7 5729 14 range range NN cord-005453-4057qib7 5729 15 , , , cord-005453-4057qib7 5729 16 1.4 1.4 CD cord-005453-4057qib7 5729 17 - - SYM cord-005453-4057qib7 5729 18 7 7 CD cord-005453-4057qib7 5729 19 ) ) -RRB- cord-005453-4057qib7 5729 20 and and CC cord-005453-4057qib7 5729 21 CRP CRP NNP cord-005453-4057qib7 5729 22 21 21 CD cord-005453-4057qib7 5729 23 mg mg NNP cord-005453-4057qib7 5729 24 / / SYM cord-005453-4057qib7 5729 25 dl dl NNP cord-005453-4057qib7 5729 26 ( ( -LRB- cord-005453-4057qib7 5729 27 range range NN cord-005453-4057qib7 5729 28 , , , cord-005453-4057qib7 5729 29 1 1 CD cord-005453-4057qib7 5729 30 - - SYM cord-005453-4057qib7 5729 31 260 260 CD cord-005453-4057qib7 5729 32 ) ) -RRB- cord-005453-4057qib7 5729 33 and and CC cord-005453-4057qib7 5729 34 60 60 CD cord-005453-4057qib7 5729 35 % % NN cord-005453-4057qib7 5729 36 of of IN cord-005453-4057qib7 5729 37 patients patient NNS cord-005453-4057qib7 5729 38 had have VBD cord-005453-4057qib7 5729 39 an an DT cord-005453-4057qib7 5729 40 active active JJ cord-005453-4057qib7 5729 41 infection infection NN cord-005453-4057qib7 5729 42 . . . cord-005453-4057qib7 5730 1 After after IN cord-005453-4057qib7 5730 2 infusion infusion NN cord-005453-4057qib7 5730 3 of of IN cord-005453-4057qib7 5730 4 the the DT cord-005453-4057qib7 5730 5 antibody antibody NN cord-005453-4057qib7 5730 6 , , , cord-005453-4057qib7 5730 7 we -PRON- PRP cord-005453-4057qib7 5730 8 observed observe VBD cord-005453-4057qib7 5730 9 a a DT cord-005453-4057qib7 5730 10 decline decline NN cord-005453-4057qib7 5730 11 of of IN cord-005453-4057qib7 5730 12 Fg Fg NNP cord-005453-4057qib7 5730 13 and and CC cord-005453-4057qib7 5730 14 CRP CRP NNP cord-005453-4057qib7 5730 15 levels level NNS cord-005453-4057qib7 5730 16 . . . cord-005453-4057qib7 5731 1 The the DT cord-005453-4057qib7 5731 2 median median JJ cord-005453-4057qib7 5731 3 level level NN cord-005453-4057qib7 5731 4 of of IN cord-005453-4057qib7 5731 5 Fg Fg NNP cord-005453-4057qib7 5731 6 was be VBD cord-005453-4057qib7 5731 7 1.02 1.02 CD cord-005453-4057qib7 5731 8 g g NN cord-005453-4057qib7 5731 9 / / SYM cord-005453-4057qib7 5731 10 l l NN cord-005453-4057qib7 5731 11 ( ( -LRB- cord-005453-4057qib7 5731 12 range range NN cord-005453-4057qib7 5731 13 , , , cord-005453-4057qib7 5731 14 0.46 0.46 CD cord-005453-4057qib7 5731 15 - - SYM cord-005453-4057qib7 5731 16 1.7 1.7 CD cord-005453-4057qib7 5731 17 ) ) -RRB- cord-005453-4057qib7 5731 18 7 7 CD cord-005453-4057qib7 5731 19 -14 -14 CD cord-005453-4057qib7 5731 20 days day NNS cord-005453-4057qib7 5731 21 after after IN cord-005453-4057qib7 5731 22 the the DT cord-005453-4057qib7 5731 23 tocilizumab tocilizumab JJ cord-005453-4057qib7 5731 24 infusion infusion NN cord-005453-4057qib7 5731 25 with with IN cord-005453-4057qib7 5731 26 no no DT cord-005453-4057qib7 5731 27 severe severe JJ cord-005453-4057qib7 5731 28 bleeding bleeding JJ cord-005453-4057qib7 5731 29 complications complication NNS cord-005453-4057qib7 5731 30 . . . cord-005453-4057qib7 5732 1 A a DT cord-005453-4057qib7 5732 2 median median JJ cord-005453-4057qib7 5732 3 CRP crp NN cord-005453-4057qib7 5732 4 value value NN cord-005453-4057qib7 5732 5 was be VBD cord-005453-4057qib7 5732 6 1.82 1.82 CD cord-005453-4057qib7 5732 7 mg mg NNP cord-005453-4057qib7 5732 8 / / SYM cord-005453-4057qib7 5732 9 dl dl NN cord-005453-4057qib7 5732 10 ( ( -LRB- cord-005453-4057qib7 5732 11 range range NN cord-005453-4057qib7 5732 12 , , , cord-005453-4057qib7 5732 13 0.1 0.1 CD cord-005453-4057qib7 5732 14 - - SYM cord-005453-4057qib7 5732 15 36 36 CD cord-005453-4057qib7 5732 16 ) ) -RRB- cord-005453-4057qib7 5732 17 despite despite IN cord-005453-4057qib7 5732 18 confirmed confirm VBD cord-005453-4057qib7 5732 19 infectious infectious JJ cord-005453-4057qib7 5732 20 complications complication NNS cord-005453-4057qib7 5732 21 . . . cord-005453-4057qib7 5733 1 Three three CD cord-005453-4057qib7 5733 2 weeks week NNS cord-005453-4057qib7 5733 3 after after IN cord-005453-4057qib7 5733 4 infusion infusion NN cord-005453-4057qib7 5733 5 of of IN cord-005453-4057qib7 5733 6 tocilizumab tocilizumab NNP cord-005453-4057qib7 5733 7 Fg Fg NNP cord-005453-4057qib7 5733 8 raised raise VBD cord-005453-4057qib7 5733 9 to to IN cord-005453-4057qib7 5733 10 the the DT cord-005453-4057qib7 5733 11 normal normal JJ cord-005453-4057qib7 5733 12 range range NN cord-005453-4057qib7 5733 13 in in IN cord-005453-4057qib7 5733 14 85 85 CD cord-005453-4057qib7 5733 15 % % NN cord-005453-4057qib7 5733 16 of of IN cord-005453-4057qib7 5733 17 patients patient NNS cord-005453-4057qib7 5733 18 ( ( -LRB- cord-005453-4057qib7 5733 19 Fig Fig NNP cord-005453-4057qib7 5733 20 1 1 CD cord-005453-4057qib7 5733 21 ) ) -RRB- cord-005453-4057qib7 5733 22 . . . cord-005453-4057qib7 5734 1 Five five CD cord-005453-4057qib7 5734 2 patients patient NNS cord-005453-4057qib7 5734 3 with with IN cord-005453-4057qib7 5734 4 SR SR NNP cord-005453-4057qib7 5734 5 aGVHD aGVHD NNP cord-005453-4057qib7 5734 6 achieved achieve VBD cord-005453-4057qib7 5734 7 a a DT cord-005453-4057qib7 5734 8 complete complete JJ cord-005453-4057qib7 5734 9 response response NN cord-005453-4057qib7 5734 10 , , , cord-005453-4057qib7 5734 11 and and CC cord-005453-4057qib7 5734 12 2 2 CD cord-005453-4057qib7 5734 13 had have VBD cord-005453-4057qib7 5734 14 a a DT cord-005453-4057qib7 5734 15 partial partial JJ cord-005453-4057qib7 5734 16 response response NN cord-005453-4057qib7 5734 17 after after IN cord-005453-4057qib7 5734 18 tocilizumab tocilizumab NNP cord-005453-4057qib7 5734 19 therapy therapy NN cord-005453-4057qib7 5734 20 . . . cord-005453-4057qib7 5735 1 [ [ -LRB- cord-005453-4057qib7 5735 2 [ [ -LRB- cord-005453-4057qib7 5735 3 P265 p265 CD cord-005453-4057qib7 5735 4 Image image NN cord-005453-4057qib7 5735 5 ] ] -RRB- cord-005453-4057qib7 5735 6 1 1 CD cord-005453-4057qib7 5735 7 . . . cord-005453-4057qib7 5736 1 Fibrinogen fibrinogen NN cord-005453-4057qib7 5736 2 levels level NNS cord-005453-4057qib7 5736 3 in in IN cord-005453-4057qib7 5736 4 GvHD gvhd NN cord-005453-4057qib7 5736 5 patients patient NNS cord-005453-4057qib7 5736 6 following follow VBG cord-005453-4057qib7 5736 7 tocilizumab tocilizumab JJ cord-005453-4057qib7 5736 8 infusion infusion NN cord-005453-4057qib7 5736 9 . . . cord-005453-4057qib7 5736 10 ] ] -RRB- cord-005453-4057qib7 5737 1 A a DT cord-005453-4057qib7 5737 2 group group NN cord-005453-4057qib7 5737 3 treated treat VBN cord-005453-4057qib7 5737 4 with with IN cord-005453-4057qib7 5737 5 tocilizumab tocilizumab NNP cord-005453-4057qib7 5737 6 due due IN cord-005453-4057qib7 5737 7 to to IN cord-005453-4057qib7 5737 8 CRS CRS NNP cord-005453-4057qib7 5737 9 had have VBD cord-005453-4057qib7 5737 10 higher high JJR cord-005453-4057qib7 5737 11 initial initial JJ cord-005453-4057qib7 5737 12 levels level NNS cord-005453-4057qib7 5737 13 of of IN cord-005453-4057qib7 5737 14 Fg Fg NNP cord-005453-4057qib7 5737 15 5.1 5.1 CD cord-005453-4057qib7 5737 16 g g NN cord-005453-4057qib7 5737 17 / / SYM cord-005453-4057qib7 5737 18 l l NN cord-005453-4057qib7 5737 19 ( ( -LRB- cord-005453-4057qib7 5737 20 range range NN cord-005453-4057qib7 5737 21 , , , cord-005453-4057qib7 5737 22 4.1 4.1 CD cord-005453-4057qib7 5737 23 - - SYM cord-005453-4057qib7 5737 24 6.6 6.6 CD cord-005453-4057qib7 5737 25 ) ) -RRB- cord-005453-4057qib7 5737 26 and and CC cord-005453-4057qib7 5737 27 CRP CRP NNP cord-005453-4057qib7 5737 28 143 143 CD cord-005453-4057qib7 5737 29 mg/ mg/ NN cord-005453-4057qib7 5737 30 dl dl NN cord-005453-4057qib7 5737 31 ( ( -LRB- cord-005453-4057qib7 5737 32 range range NN cord-005453-4057qib7 5737 33 , , , cord-005453-4057qib7 5737 34 80 80 CD cord-005453-4057qib7 5737 35 - - SYM cord-005453-4057qib7 5737 36 227 227 CD cord-005453-4057qib7 5737 37 ) ) -RRB- cord-005453-4057qib7 5738 1 before before IN cord-005453-4057qib7 5738 2 administration administration NN cord-005453-4057qib7 5738 3 of of IN cord-005453-4057qib7 5738 4 the the DT cord-005453-4057qib7 5738 5 drug drug NN cord-005453-4057qib7 5738 6 . . . cord-005453-4057qib7 5739 1 Reduced reduced JJ cord-005453-4057qib7 5739 2 Fg Fg NNP cord-005453-4057qib7 5739 3 and and CC cord-005453-4057qib7 5739 4 CRP CRP NNP cord-005453-4057qib7 5739 5 levels level NNS cord-005453-4057qib7 5739 6 from from IN cord-005453-4057qib7 5739 7 a a DT cord-005453-4057qib7 5739 8 baseline baseline JJ cord-005453-4057qib7 5739 9 value value NN cord-005453-4057qib7 5739 10 were be VBD cord-005453-4057qib7 5739 11 also also RB cord-005453-4057qib7 5739 12 observed observe VBN cord-005453-4057qib7 5739 13 in in IN cord-005453-4057qib7 5739 14 this this DT cord-005453-4057qib7 5739 15 group group NN cord-005453-4057qib7 5739 16 . . . cord-005453-4057qib7 5740 1 However however RB cord-005453-4057qib7 5740 2 , , , cord-005453-4057qib7 5740 3 concentrations concentration NNS cord-005453-4057qib7 5740 4 were be VBD cord-005453-4057qib7 5740 5 higher high JJR cord-005453-4057qib7 5740 6 than than IN cord-005453-4057qib7 5740 7 in in IN cord-005453-4057qib7 5740 8 GVHD GVHD NNP cord-005453-4057qib7 5740 9 patients patient NNS cord-005453-4057qib7 5740 10 : : : cord-005453-4057qib7 5741 1 Fg Fg NNP cord-005453-4057qib7 5741 2 2.02 2.02 CD cord-005453-4057qib7 5741 3 g g NN cord-005453-4057qib7 5741 4 / / SYM cord-005453-4057qib7 5741 5 l l NN cord-005453-4057qib7 5741 6 ( ( -LRB- cord-005453-4057qib7 5741 7 range range NNP cord-005453-4057qib7 5741 8 1.2 1.2 CD cord-005453-4057qib7 5741 9 - - SYM cord-005453-4057qib7 5741 10 3.4 3.4 CD cord-005453-4057qib7 5741 11 ) ) -RRB- cord-005453-4057qib7 5741 12 and and CC cord-005453-4057qib7 5741 13 CRP CRP NNP cord-005453-4057qib7 5741 14 3.2 3.2 CD cord-005453-4057qib7 5741 15 mg mg NNP cord-005453-4057qib7 5741 16 / / SYM cord-005453-4057qib7 5741 17 dl dl NNP cord-005453-4057qib7 5741 18 ( ( -LRB- cord-005453-4057qib7 5741 19 range range NNP cord-005453-4057qib7 5741 20 2.7 2.7 CD cord-005453-4057qib7 5741 21 - - SYM cord-005453-4057qib7 5741 22 11 11 CD cord-005453-4057qib7 5741 23 ) ) -RRB- cord-005453-4057qib7 5741 24 . . . cord-005453-4057qib7 5742 1 In in IN cord-005453-4057qib7 5742 2 all all DT cord-005453-4057qib7 5742 3 patients patient NNS cord-005453-4057qib7 5742 4 , , , cord-005453-4057qib7 5742 5 a a DT cord-005453-4057qib7 5742 6 differential differential JJ cord-005453-4057qib7 5742 7 diagnosis diagnosis NN cord-005453-4057qib7 5742 8 of of IN cord-005453-4057qib7 5742 9 disseminated disseminate VBN cord-005453-4057qib7 5742 10 intravascular intravascular JJ cord-005453-4057qib7 5742 11 coagulation coagulation NN cord-005453-4057qib7 5742 12 was be VBD cord-005453-4057qib7 5742 13 excluded exclude VBN cord-005453-4057qib7 5742 14 . . . cord-005453-4057qib7 5743 1 Conclusions conclusion NNS cord-005453-4057qib7 5743 2 : : : cord-005453-4057qib7 5743 3 1 1 CD cord-005453-4057qib7 5743 4 . . . cord-005453-4057qib7 5744 1 Fibrinogen fibrinogen NN cord-005453-4057qib7 5744 2 declines decline VBZ cord-005453-4057qib7 5744 3 after after IN cord-005453-4057qib7 5744 4 tocilizumab tocilizumab NNP cord-005453-4057qib7 5744 5 therapy therapy NN cord-005453-4057qib7 5744 6 due due IN cord-005453-4057qib7 5744 7 to to IN cord-005453-4057qib7 5744 8 its -PRON- PRP$ cord-005453-4057qib7 5744 9 cytokine cytokine NN cord-005453-4057qib7 5744 10 - - HYPH cord-005453-4057qib7 5744 11 regulated regulate VBN cord-005453-4057qib7 5744 12 production production NN cord-005453-4057qib7 5744 13 in in IN cord-005453-4057qib7 5744 14 the the DT cord-005453-4057qib7 5744 15 liver liver NN cord-005453-4057qib7 5744 16 . . . cord-005453-4057qib7 5745 1 Coagulation coagulation NN cord-005453-4057qib7 5745 2 monitoring monitoring NN cord-005453-4057qib7 5745 3 should should MD cord-005453-4057qib7 5745 4 be be VB cord-005453-4057qib7 5745 5 performed perform VBN cord-005453-4057qib7 5745 6 during during IN cord-005453-4057qib7 5745 7 the the DT cord-005453-4057qib7 5745 8 first first JJ cord-005453-4057qib7 5745 9 3 3 CD cord-005453-4057qib7 5745 10 weeks week NNS cord-005453-4057qib7 5745 11 after after IN cord-005453-4057qib7 5745 12 administration administration NN cord-005453-4057qib7 5745 13 of of IN cord-005453-4057qib7 5745 14 the the DT cord-005453-4057qib7 5745 15 antibody antibody NN cord-005453-4057qib7 5745 16 to to TO cord-005453-4057qib7 5745 17 avoid avoid VB cord-005453-4057qib7 5745 18 serious serious JJ cord-005453-4057qib7 5745 19 bleeding bleeding JJ cord-005453-4057qib7 5745 20 complications complication NNS cord-005453-4057qib7 5745 21 . . . cord-005453-4057qib7 5746 1 2 2 LS cord-005453-4057qib7 5746 2 . . . cord-005453-4057qib7 5747 1 CRP CRP NNP cord-005453-4057qib7 5747 2 concentrations concentration NNS cord-005453-4057qib7 5747 3 remain remain VBP cord-005453-4057qib7 5747 4 low low JJ cord-005453-4057qib7 5747 5 despite despite IN cord-005453-4057qib7 5747 6 the the DT cord-005453-4057qib7 5747 7 presence presence NN cord-005453-4057qib7 5747 8 of of IN cord-005453-4057qib7 5747 9 active active JJ cord-005453-4057qib7 5747 10 infections infection NNS cord-005453-4057qib7 5747 11 following follow VBG cord-005453-4057qib7 5747 12 infusion infusion NN cord-005453-4057qib7 5747 13 of of IN cord-005453-4057qib7 5747 14 tocilizumab tocilizumab NNP cord-005453-4057qib7 5747 15 . . . cord-005453-4057qib7 5748 1 CRP CRP NNP cord-005453-4057qib7 5748 2 fails fail VBZ cord-005453-4057qib7 5748 3 as as IN cord-005453-4057qib7 5748 4 a a DT cord-005453-4057qib7 5748 5 marker marker NN cord-005453-4057qib7 5748 6 of of IN cord-005453-4057qib7 5748 7 infection infection NN cord-005453-4057qib7 5748 8 during during IN cord-005453-4057qib7 5748 9 3 3 CD cord-005453-4057qib7 5748 10 weeks week NNS cord-005453-4057qib7 5748 11 following follow VBG cord-005453-4057qib7 5748 12 the the DT cord-005453-4057qib7 5748 13 therapy therapy NN cord-005453-4057qib7 5748 14 . . . cord-005453-4057qib7 5749 1 3 3 LS cord-005453-4057qib7 5749 2 . . . cord-005453-4057qib7 5750 1 Tocilizumab Tocilizumab NNP cord-005453-4057qib7 5750 2 is be VBZ cord-005453-4057qib7 5750 3 an an DT cord-005453-4057qib7 5750 4 effective effective JJ cord-005453-4057qib7 5750 5 therapy therapy NN cord-005453-4057qib7 5750 6 in in IN cord-005453-4057qib7 5750 7 patients patient NNS cord-005453-4057qib7 5750 8 with with IN cord-005453-4057qib7 5750 9 aGvHD agvhd NN cord-005453-4057qib7 5750 10 , , , cord-005453-4057qib7 5750 11 especially especially RB cord-005453-4057qib7 5750 12 with with IN cord-005453-4057qib7 5750 13 the the DT cord-005453-4057qib7 5750 14 GI GI NNP cord-005453-4057qib7 5750 15 involvement involvement NN cord-005453-4057qib7 5750 16 . . . cord-005453-4057qib7 5751 1 Disclosure disclosure NN cord-005453-4057qib7 5751 2 : : : cord-005453-4057qib7 5751 3 Nothing nothing NN cord-005453-4057qib7 5751 4 to to TO cord-005453-4057qib7 5751 5 declare declare VB cord-005453-4057qib7 5751 6 Vanishing vanish VBG cord-005453-4057qib7 5751 7 bile bile NN cord-005453-4057qib7 5751 8 ducts duct NNS cord-005453-4057qib7 5751 9 after after IN cord-005453-4057qib7 5751 10 allogenic allogenic JJ cord-005453-4057qib7 5751 11 HSCT HSCT NNP cord-005453-4057qib7 5751 12 : : : cord-005453-4057qib7 5752 1 Is be VBZ cord-005453-4057qib7 5752 2 it -PRON- PRP cord-005453-4057qib7 5752 3 really really RB cord-005453-4057qib7 5752 4 GVHD gvhd JJ cord-005453-4057qib7 5752 5 ? ? . cord-005453-4057qib7 5753 1 Antonio Antonio NNP cord-005453-4057qib7 5753 2 Grasso Grasso NNP cord-005453-4057qib7 5753 3 1 1 CD cord-005453-4057qib7 5753 4 , , , cord-005453-4057qib7 5753 5 Lorenzo Lorenzo NNP cord-005453-4057qib7 5753 6 D'Antiga D'Antiga NNP cord-005453-4057qib7 5753 7 2 2 CD cord-005453-4057qib7 5753 8 , , , cord-005453-4057qib7 5753 9 Aurelio Aurelio NNP cord-005453-4057qib7 5753 10 Sonzogni Sonzogni NNP cord-005453-4057qib7 5753 11 2 2 CD cord-005453-4057qib7 5753 12 , , , cord-005453-4057qib7 5753 13 Massimo Massimo NNP cord-005453-4057qib7 5753 14 Gregori Gregori NNP cord-005453-4057qib7 5753 15 3 3 CD cord-005453-4057qib7 5753 16 , , , cord-005453-4057qib7 5753 17 Alessandra Alessandra NNP cord-005453-4057qib7 5753 18 Maestro Maestro NNP cord-005453-4057qib7 5753 19 3 3 CD cord-005453-4057qib7 5753 20 , , , cord-005453-4057qib7 5753 21 Roberto Roberto NNP cord-005453-4057qib7 5753 22 Simeone Simeone NNP cord-005453-4057qib7 5753 23 3 3 CD cord-005453-4057qib7 5753 24 , , , cord-005453-4057qib7 5753 25 Natalia Natalia NNP cord-005453-4057qib7 5753 26 Maximova Maximova NNP cord-005453-4057qib7 5753 27 3 3 CD cord-005453-4057qib7 5753 28 Background Background NNP cord-005453-4057qib7 5753 29 : : : cord-005453-4057qib7 5754 1 Evaluation evaluation NN cord-005453-4057qib7 5754 2 of of IN cord-005453-4057qib7 5754 3 liver liver NN cord-005453-4057qib7 5754 4 GVHD GVHD NNP cord-005453-4057qib7 5754 5 was be VBD cord-005453-4057qib7 5754 6 historically historically RB cord-005453-4057qib7 5754 7 based base VBN cord-005453-4057qib7 5754 8 by by IN cord-005453-4057qib7 5754 9 elevation elevation NN cord-005453-4057qib7 5754 10 of of IN cord-005453-4057qib7 5754 11 bilirubin bilirubin JJ cord-005453-4057qib7 5754 12 levels level NNS cord-005453-4057qib7 5754 13 and and CC cord-005453-4057qib7 5754 14 by by IN cord-005453-4057qib7 5754 15 reduction reduction NN cord-005453-4057qib7 5754 16 and and CC cord-005453-4057qib7 5754 17 degeneration degeneration NN cord-005453-4057qib7 5754 18 of of IN cord-005453-4057qib7 5754 19 small small JJ cord-005453-4057qib7 5754 20 bile bile NN cord-005453-4057qib7 5754 21 ducts duct NNS cord-005453-4057qib7 5754 22 on on IN cord-005453-4057qib7 5754 23 histological histological JJ cord-005453-4057qib7 5754 24 samples sample NNS cord-005453-4057qib7 5754 25 of of IN cord-005453-4057qib7 5754 26 post post JJ cord-005453-4057qib7 5754 27 - - JJ cord-005453-4057qib7 5754 28 transplant transplant JJ cord-005453-4057qib7 5754 29 liver liver NN cord-005453-4057qib7 5754 30 biopsy biopsy NN cord-005453-4057qib7 5754 31 . . . cord-005453-4057qib7 5755 1 However however RB cord-005453-4057qib7 5755 2 , , , cord-005453-4057qib7 5755 3 there there EX cord-005453-4057qib7 5755 4 is be VBZ cord-005453-4057qib7 5755 5 a a DT cord-005453-4057qib7 5755 6 lack lack NN cord-005453-4057qib7 5755 7 of of IN cord-005453-4057qib7 5755 8 studies study NNS cord-005453-4057qib7 5755 9 that that WDT cord-005453-4057qib7 5755 10 compared compare VBD cord-005453-4057qib7 5755 11 histological histological JJ cord-005453-4057qib7 5755 12 finding finding NN cord-005453-4057qib7 5755 13 of of IN cord-005453-4057qib7 5755 14 ductopenia ductopenia NN cord-005453-4057qib7 5755 15 between between IN cord-005453-4057qib7 5755 16 post post JJ cord-005453-4057qib7 5755 17 - - JJ cord-005453-4057qib7 5755 18 autologous autologous JJ cord-005453-4057qib7 5755 19 HSCT HSCT NNP cord-005453-4057qib7 5755 20 and and CC cord-005453-4057qib7 5755 21 post post JJ cord-005453-4057qib7 5755 22 - - JJ cord-005453-4057qib7 5755 23 allogenic allogenic JJ cord-005453-4057qib7 5755 24 HSCT HSCT NNP cord-005453-4057qib7 5755 25 . . . cord-005453-4057qib7 5756 1 Studying study VBG cord-005453-4057qib7 5756 2 severity severity NN cord-005453-4057qib7 5756 3 of of IN cord-005453-4057qib7 5756 4 ductopenia ductopenia NN cord-005453-4057qib7 5756 5 following follow VBG cord-005453-4057qib7 5756 6 allogenic allogenic JJ cord-005453-4057qib7 5756 7 HSCT HSCT NNP cord-005453-4057qib7 5756 8 , , , cord-005453-4057qib7 5756 9 we -PRON- PRP cord-005453-4057qib7 5756 10 aimed aim VBD cord-005453-4057qib7 5756 11 to to TO cord-005453-4057qib7 5756 12 demonstrate demonstrate VB cord-005453-4057qib7 5756 13 lack lack NN cord-005453-4057qib7 5756 14 of of IN cord-005453-4057qib7 5756 15 correlation correlation NN cord-005453-4057qib7 5756 16 between between IN cord-005453-4057qib7 5756 17 ductopenia ductopenia NN cord-005453-4057qib7 5756 18 and and CC cord-005453-4057qib7 5756 19 clinical clinical JJ cord-005453-4057qib7 5756 20 signs sign NNS cord-005453-4057qib7 5756 21 of of IN cord-005453-4057qib7 5756 22 liver liver NN cord-005453-4057qib7 5756 23 GVHD GVHD NNP cord-005453-4057qib7 5756 24 . . . cord-005453-4057qib7 5757 1 Methods method NNS cord-005453-4057qib7 5757 2 : : : cord-005453-4057qib7 5757 3 We -PRON- PRP cord-005453-4057qib7 5757 4 retrospectively retrospectively RB cord-005453-4057qib7 5757 5 collected collect VBD cord-005453-4057qib7 5757 6 a a DT cord-005453-4057qib7 5757 7 series series NN cord-005453-4057qib7 5757 8 of of IN cord-005453-4057qib7 5757 9 72 72 CD cord-005453-4057qib7 5757 10 allogeneic allogeneic NN cord-005453-4057qib7 5757 11 HSCT HSCT NNP cord-005453-4057qib7 5757 12 performed perform VBN cord-005453-4057qib7 5757 13 from from IN cord-005453-4057qib7 5757 14 2005 2005 CD cord-005453-4057qib7 5757 15 to to IN cord-005453-4057qib7 5757 16 2017 2017 CD cord-005453-4057qib7 5757 17 in in IN cord-005453-4057qib7 5757 18 the the DT cord-005453-4057qib7 5757 19 Institute Institute NNP cord-005453-4057qib7 5757 20 Burlo Burlo NNP cord-005453-4057qib7 5757 21 Garofolo Garofolo NNP cord-005453-4057qib7 5757 22 . . . cord-005453-4057qib7 5758 1 All all DT cord-005453-4057qib7 5758 2 patients patient NNS cord-005453-4057qib7 5758 3 undergo undergo VBP cord-005453-4057qib7 5758 4 percutaneous percutaneous JJ cord-005453-4057qib7 5758 5 liver liver NN cord-005453-4057qib7 5758 6 biopsy biopsy NN cord-005453-4057qib7 5758 7 in in IN cord-005453-4057qib7 5758 8 most most JJS cord-005453-4057qib7 5758 9 cases case NNS cord-005453-4057qib7 5758 10 at at IN cord-005453-4057qib7 5758 11 three three CD cord-005453-4057qib7 5758 12 months month NNS cord-005453-4057qib7 5758 13 , , , cord-005453-4057qib7 5758 14 one one CD cord-005453-4057qib7 5758 15 year year NN cord-005453-4057qib7 5758 16 and and CC cord-005453-4057qib7 5758 17 three three CD cord-005453-4057qib7 5758 18 or or CC cord-005453-4057qib7 5758 19 more more JJR cord-005453-4057qib7 5758 20 years year NNS cord-005453-4057qib7 5758 21 after after IN cord-005453-4057qib7 5758 22 HSCT HSCT NNP cord-005453-4057qib7 5758 23 . . . cord-005453-4057qib7 5759 1 Indications indication NNS cord-005453-4057qib7 5759 2 for for IN cord-005453-4057qib7 5759 3 biopsy biopsy NN cord-005453-4057qib7 5759 4 were be VBD cord-005453-4057qib7 5759 5 alteration alteration NN cord-005453-4057qib7 5759 6 noted note VBN cord-005453-4057qib7 5759 7 at at IN cord-005453-4057qib7 5759 8 2 2 CD cord-005453-4057qib7 5759 9 weekly weekly JJ cord-005453-4057qib7 5759 10 follow follow NN cord-005453-4057qib7 5759 11 - - HYPH cord-005453-4057qib7 5759 12 up up RP cord-005453-4057qib7 5759 13 assessments assessment NNS cord-005453-4057qib7 5759 14 of of IN cord-005453-4057qib7 5759 15 at at RB cord-005453-4057qib7 5759 16 least least RBS cord-005453-4057qib7 5759 17 one one CD cord-005453-4057qib7 5759 18 clinical clinical JJ cord-005453-4057qib7 5759 19 or or CC cord-005453-4057qib7 5759 20 laboratory laboratory NN cord-005453-4057qib7 5759 21 marker marker NN cord-005453-4057qib7 5759 22 of of IN cord-005453-4057qib7 5759 23 liver liver NN cord-005453-4057qib7 5759 24 impairment impairment NN cord-005453-4057qib7 5759 25 or or CC cord-005453-4057qib7 5759 26 cholestasis cholestasis NN cord-005453-4057qib7 5759 27 . . . cord-005453-4057qib7 5760 1 Ductopenia Ductopenia NNP cord-005453-4057qib7 5760 2 was be VBD cord-005453-4057qib7 5760 3 defined define VBN cord-005453-4057qib7 5760 4 by by IN cord-005453-4057qib7 5760 5 number number NN cord-005453-4057qib7 5760 6 of of IN cord-005453-4057qib7 5760 7 portal portal JJ cord-005453-4057qib7 5760 8 tracts tract NNS cord-005453-4057qib7 5760 9 with with IN cord-005453-4057qib7 5760 10 no no DT cord-005453-4057qib7 5760 11 interlobular interlobular JJ cord-005453-4057qib7 5760 12 bile bile NN cord-005453-4057qib7 5760 13 duct duct NN cord-005453-4057qib7 5760 14 divided divide VBN cord-005453-4057qib7 5760 15 by by IN cord-005453-4057qib7 5760 16 the the DT cord-005453-4057qib7 5760 17 total total JJ cord-005453-4057qib7 5760 18 number number NN cord-005453-4057qib7 5760 19 ( ( -LRB- cord-005453-4057qib7 5760 20 severe severe JJ cord-005453-4057qib7 5760 21 if if IN cord-005453-4057qib7 5760 22 the the DT cord-005453-4057qib7 5760 23 ratio ratio NN cord-005453-4057qib7 5760 24 was be VBD cord-005453-4057qib7 5760 25 less less JJR cord-005453-4057qib7 5760 26 than than IN cord-005453-4057qib7 5760 27 0.2 0.2 CD cord-005453-4057qib7 5760 28 ) ) -RRB- cord-005453-4057qib7 5760 29 . . . cord-005453-4057qib7 5761 1 Clinical clinical JJ cord-005453-4057qib7 5761 2 GVHD GVHD NNP cord-005453-4057qib7 5761 3 was be VBD cord-005453-4057qib7 5761 4 defined define VBN cord-005453-4057qib7 5761 5 by by IN cord-005453-4057qib7 5761 6 NIH NIH NNP cord-005453-4057qib7 5761 7 consensus consensus NN cord-005453-4057qib7 5761 8 criteria criterion NNS cord-005453-4057qib7 5761 9 Results result NNS cord-005453-4057qib7 5761 10 : : : cord-005453-4057qib7 5762 1 Our -PRON- PRP$ cord-005453-4057qib7 5762 2 population population NN cord-005453-4057qib7 5762 3 involved involve VBD cord-005453-4057qib7 5762 4 64 64 CD cord-005453-4057qib7 5762 5 % % NN cord-005453-4057qib7 5762 6 males male NNS cord-005453-4057qib7 5762 7 and and CC cord-005453-4057qib7 5762 8 36 36 CD cord-005453-4057qib7 5762 9 % % NN cord-005453-4057qib7 5762 10 females female NNS cord-005453-4057qib7 5762 11 with with IN cord-005453-4057qib7 5762 12 oncological oncological JJ cord-005453-4057qib7 5762 13 ( ( -LRB- cord-005453-4057qib7 5762 14 70 70 CD cord-005453-4057qib7 5762 15 % % NN cord-005453-4057qib7 5762 16 ) ) -RRB- cord-005453-4057qib7 5762 17 and and CC cord-005453-4057qib7 5762 18 non non JJ cord-005453-4057qib7 5762 19 - - JJ cord-005453-4057qib7 5762 20 oncological oncological JJ cord-005453-4057qib7 5762 21 underlying underlie VBG cord-005453-4057qib7 5762 22 disease disease NN cord-005453-4057qib7 5762 23 ( ( -LRB- cord-005453-4057qib7 5762 24 30 30 CD cord-005453-4057qib7 5762 25 % % NN cord-005453-4057qib7 5762 26 ) ) -RRB- cord-005453-4057qib7 5762 27 . . . cord-005453-4057qib7 5763 1 Clinical clinical JJ cord-005453-4057qib7 5763 2 signs sign NNS cord-005453-4057qib7 5763 3 of of IN cord-005453-4057qib7 5763 4 liver liver NN cord-005453-4057qib7 5763 5 GVHD GVHD NNP cord-005453-4057qib7 5763 6 were be VBD cord-005453-4057qib7 5763 7 present present JJ cord-005453-4057qib7 5763 8 in in IN cord-005453-4057qib7 5763 9 18 18 CD cord-005453-4057qib7 5763 10 % % NN cord-005453-4057qib7 5763 11 of of IN cord-005453-4057qib7 5763 12 the the DT cord-005453-4057qib7 5763 13 patients patient NNS cord-005453-4057qib7 5763 14 ( ( -LRB- cord-005453-4057qib7 5763 15 n=13 n=13 NNP cord-005453-4057qib7 5763 16 ) ) -RRB- cord-005453-4057qib7 5763 17 , , , cord-005453-4057qib7 5763 18 8 8 CD cord-005453-4057qib7 5763 19 % % NN cord-005453-4057qib7 5763 20 with with IN cord-005453-4057qib7 5763 21 contextual contextual JJ cord-005453-4057qib7 5763 22 intestinal intestinal JJ cord-005453-4057qib7 5763 23 involvement involvement NN cord-005453-4057qib7 5763 24 , , , cord-005453-4057qib7 5763 25 8 8 CD cord-005453-4057qib7 5763 26 % % NN cord-005453-4057qib7 5763 27 with with IN cord-005453-4057qib7 5763 28 cutaneous cutaneous JJ cord-005453-4057qib7 5763 29 and and CC cord-005453-4057qib7 5763 30 intestinal intestinal JJ cord-005453-4057qib7 5763 31 involvement involvement NN cord-005453-4057qib7 5763 32 . . . cord-005453-4057qib7 5764 1 71 71 CD cord-005453-4057qib7 5764 2 patients patient NNS cord-005453-4057qib7 5764 3 underwent undergo VBD cord-005453-4057qib7 5764 4 biopsy biopsy JJ cord-005453-4057qib7 5764 5 at at IN cord-005453-4057qib7 5764 6 a a DT cord-005453-4057qib7 5764 7 mean mean JJ cord-005453-4057qib7 5764 8 time time NN cord-005453-4057qib7 5764 9 of of IN cord-005453-4057qib7 5764 10 110 110 CD cord-005453-4057qib7 5765 1 + + CC cord-005453-4057qib7 5765 2 /-32 /-32 CD cord-005453-4057qib7 5765 3 days day NNS cord-005453-4057qib7 5765 4 after after IN cord-005453-4057qib7 5765 5 HSCT HSCT NNP cord-005453-4057qib7 5765 6 , , , cord-005453-4057qib7 5765 7 45 45 CD cord-005453-4057qib7 5765 8 patients patient NNS cord-005453-4057qib7 5765 9 underwent undergo VBD cord-005453-4057qib7 5765 10 a a DT cord-005453-4057qib7 5765 11 biopsy biopsy NN cord-005453-4057qib7 5765 12 at at IN cord-005453-4057qib7 5765 13 12 12 CD cord-005453-4057qib7 5765 14 months month NNS cord-005453-4057qib7 5765 15 after after IN cord-005453-4057qib7 5765 16 HSCT HSCT NNP cord-005453-4057qib7 5765 17 and and CC cord-005453-4057qib7 5765 18 35 35 CD cord-005453-4057qib7 5765 19 patients patient NNS cord-005453-4057qib7 5765 20 after after IN cord-005453-4057qib7 5765 21 three three CD cord-005453-4057qib7 5765 22 or or CC cord-005453-4057qib7 5765 23 more more JJR cord-005453-4057qib7 5765 24 years year NNS cord-005453-4057qib7 5765 25 from from IN cord-005453-4057qib7 5765 26 HSCT HSCT NNP cord-005453-4057qib7 5765 27 . . . cord-005453-4057qib7 5766 1 Results result NNS cord-005453-4057qib7 5766 2 of of IN cord-005453-4057qib7 5766 3 biopsies biopsy NNS cord-005453-4057qib7 5766 4 are be VBP cord-005453-4057qib7 5766 5 showed show VBN cord-005453-4057qib7 5766 6 in in IN cord-005453-4057qib7 5766 7 table table NN cord-005453-4057qib7 5766 8 1 1 CD cord-005453-4057qib7 5766 9 . . . cord-005453-4057qib7 5767 1 No no DT cord-005453-4057qib7 5767 2 difference difference NN cord-005453-4057qib7 5767 3 in in IN cord-005453-4057qib7 5767 4 incidence incidence NN cord-005453-4057qib7 5767 5 of of IN cord-005453-4057qib7 5767 6 ductopenia ductopenia NNP cord-005453-4057qib7 5767 7 were be VBD cord-005453-4057qib7 5767 8 found find VBN cord-005453-4057qib7 5767 9 between between IN cord-005453-4057qib7 5767 10 liver liver NN cord-005453-4057qib7 5767 11 GVHD GVHD NNP cord-005453-4057qib7 5767 12 group group NN cord-005453-4057qib7 5767 13 and and CC cord-005453-4057qib7 5767 14 no no DT cord-005453-4057qib7 5767 15 GVHD GVHD NNP cord-005453-4057qib7 5767 16 . . . cord-005453-4057qib7 5768 1 Table table NN cord-005453-4057qib7 5768 2 ] ] -RRB- cord-005453-4057qib7 5768 3 1 1 CD cord-005453-4057qib7 5768 4 . . . cord-005453-4057qib7 5769 1 Table table NN cord-005453-4057qib7 5769 2 1 1 CD cord-005453-4057qib7 5769 3 : : : cord-005453-4057qib7 5769 4 Incidence incidence NN cord-005453-4057qib7 5769 5 of of IN cord-005453-4057qib7 5769 6 ductopenia ductopenia NNP cord-005453-4057qib7 5769 7 3 3 CD cord-005453-4057qib7 5769 8 - - SYM cord-005453-4057qib7 5769 9 6 6 CD cord-005453-4057qib7 5769 10 months month NNS cord-005453-4057qib7 5769 11 , , , cord-005453-4057qib7 5769 12 12 12 CD cord-005453-4057qib7 5769 13 months month NNS cord-005453-4057qib7 5769 14 and and CC cord-005453-4057qib7 5769 15 3 3 CD cord-005453-4057qib7 5769 16 or or CC cord-005453-4057qib7 5769 17 more more JJR cord-005453-4057qib7 5769 18 years year NNS cord-005453-4057qib7 5769 19 after after IN cord-005453-4057qib7 5769 20 HSCT HSCT NNP cord-005453-4057qib7 5769 21 in in IN cord-005453-4057qib7 5769 22 total total JJ cord-005453-4057qib7 5769 23 population population NN cord-005453-4057qib7 5769 24 , , , cord-005453-4057qib7 5769 25 GVHD GVHD NNP cord-005453-4057qib7 5769 26 group group NN cord-005453-4057qib7 5769 27 and and CC cord-005453-4057qib7 5769 28 no no DT cord-005453-4057qib7 5769 29 - - HYPH cord-005453-4057qib7 5769 30 GVHD GVHD NNP cord-005453-4057qib7 5769 31 group group NN cord-005453-4057qib7 5769 32 ] ] -RRB- cord-005453-4057qib7 5770 1 The the DT cord-005453-4057qib7 5770 2 group group NN cord-005453-4057qib7 5770 3 that that WDT cord-005453-4057qib7 5770 4 not not RB cord-005453-4057qib7 5770 5 received receive VBD cord-005453-4057qib7 5770 6 chemotherapy chemotherapy NN cord-005453-4057qib7 5770 7 prior prior IN cord-005453-4057qib7 5770 8 the the DT cord-005453-4057qib7 5770 9 HSCT HSCT NNP cord-005453-4057qib7 5770 10 had have VBD cord-005453-4057qib7 5770 11 an an DT cord-005453-4057qib7 5770 12 overall overall JJ cord-005453-4057qib7 5770 13 incidence incidence NN cord-005453-4057qib7 5770 14 of of IN cord-005453-4057qib7 5770 15 ductopenia ductopenia NN cord-005453-4057qib7 5770 16 of of IN cord-005453-4057qib7 5770 17 77 77 CD cord-005453-4057qib7 5770 18 % % NN cord-005453-4057qib7 5770 19 ( ( -LRB- cord-005453-4057qib7 5770 20 severe severe JJ cord-005453-4057qib7 5770 21 ductopenia ductopenia NN cord-005453-4057qib7 5770 22 of of IN cord-005453-4057qib7 5770 23 42 42 CD cord-005453-4057qib7 5770 24 % % NN cord-005453-4057qib7 5770 25 ) ) -RRB- cord-005453-4057qib7 5770 26 statistically statistically RB cord-005453-4057qib7 5770 27 significative significative JJ cord-005453-4057qib7 5770 28 in in IN cord-005453-4057qib7 5770 29 comparison comparison NN cord-005453-4057qib7 5770 30 with with IN cord-005453-4057qib7 5770 31 the the DT cord-005453-4057qib7 5770 32 oncological oncological JJ cord-005453-4057qib7 5770 33 underlying underlie VBG cord-005453-4057qib7 5770 34 disease disease NN cord-005453-4057qib7 5770 35 group group NN cord-005453-4057qib7 5770 36 ( ( -LRB- cord-005453-4057qib7 5770 37 94 94 CD cord-005453-4057qib7 5770 38 % % NN cord-005453-4057qib7 5770 39 of of IN cord-005453-4057qib7 5770 40 ductopenia ductopenia NN cord-005453-4057qib7 5770 41 and and CC cord-005453-4057qib7 5770 42 64 64 CD cord-005453-4057qib7 5770 43 % % NN cord-005453-4057qib7 5770 44 of of IN cord-005453-4057qib7 5770 45 severe severe JJ cord-005453-4057qib7 5770 46 ductopenia ductopenia NN cord-005453-4057qib7 5770 47 ) ) -RRB- cord-005453-4057qib7 5770 48 . . . cord-005453-4057qib7 5771 1 Furthermore furthermore RB cord-005453-4057qib7 5771 2 , , , cord-005453-4057qib7 5771 3 a a DT cord-005453-4057qib7 5771 4 little little JJ cord-005453-4057qib7 5771 5 sub sub NN cord-005453-4057qib7 5771 6 - - JJ cord-005453-4057qib7 5771 7 group group NN cord-005453-4057qib7 5771 8 of of IN cord-005453-4057qib7 5771 9 16 16 CD cord-005453-4057qib7 5771 10 patients patient NNS cord-005453-4057qib7 5771 11 extrapolated extrapolate VBN cord-005453-4057qib7 5771 12 from from IN cord-005453-4057qib7 5771 13 our -PRON- PRP$ cord-005453-4057qib7 5771 14 population population NN cord-005453-4057qib7 5771 15 received receive VBD cord-005453-4057qib7 5771 16 liver liver NN cord-005453-4057qib7 5771 17 biopsy biopsy NN cord-005453-4057qib7 5771 18 before before IN cord-005453-4057qib7 5771 19 HSCT HSCT NNP cord-005453-4057qib7 5771 20 for for IN cord-005453-4057qib7 5771 21 diagnostic diagnostic JJ cord-005453-4057qib7 5771 22 assessments assessment NNS cord-005453-4057qib7 5771 23 : : : cord-005453-4057qib7 5771 24 of of IN cord-005453-4057qib7 5771 25 the the DT cord-005453-4057qib7 5771 26 10 10 CD cord-005453-4057qib7 5771 27 with with IN cord-005453-4057qib7 5771 28 an an DT cord-005453-4057qib7 5771 29 oncological oncological JJ cord-005453-4057qib7 5771 30 underlying underlie VBG cord-005453-4057qib7 5771 31 disease disease NN cord-005453-4057qib7 5771 32 70 70 CD cord-005453-4057qib7 5771 33 % % NN cord-005453-4057qib7 5771 34 already already RB cord-005453-4057qib7 5771 35 showed show VBD cord-005453-4057qib7 5771 36 ductopenia ductopenia NNP cord-005453-4057qib7 5771 37 , , , cord-005453-4057qib7 5771 38 while while IN cord-005453-4057qib7 5771 39 no no DT cord-005453-4057qib7 5771 40 signs sign NNS cord-005453-4057qib7 5771 41 of of IN cord-005453-4057qib7 5771 42 ductopenia ductopenia NNP cord-005453-4057qib7 5771 43 were be VBD cord-005453-4057qib7 5771 44 found find VBN cord-005453-4057qib7 5771 45 in in IN cord-005453-4057qib7 5771 46 the the DT cord-005453-4057qib7 5771 47 others other NNS cord-005453-4057qib7 5771 48 with with IN cord-005453-4057qib7 5771 49 a a DT cord-005453-4057qib7 5771 50 nononcological nononcological JJ cord-005453-4057qib7 5771 51 disease disease NN cord-005453-4057qib7 5771 52 . . . cord-005453-4057qib7 5772 1 Conclusions conclusion NNS cord-005453-4057qib7 5772 2 : : : cord-005453-4057qib7 5773 1 There there EX cord-005453-4057qib7 5773 2 is be VBZ cord-005453-4057qib7 5773 3 no no DT cord-005453-4057qib7 5773 4 correlation correlation NN cord-005453-4057qib7 5773 5 between between IN cord-005453-4057qib7 5773 6 incidence incidence NN cord-005453-4057qib7 5773 7 of of IN cord-005453-4057qib7 5773 8 GVHD GVHD NNP cord-005453-4057qib7 5773 9 and and CC cord-005453-4057qib7 5773 10 histologically histologically RB cord-005453-4057qib7 5773 11 finding find VBG cord-005453-4057qib7 5773 12 of of IN cord-005453-4057qib7 5773 13 ductopenia ductopenia NNP cord-005453-4057qib7 5773 14 on on IN cord-005453-4057qib7 5773 15 liver liver NN cord-005453-4057qib7 5773 16 biopsy biopsy NN cord-005453-4057qib7 5773 17 . . . cord-005453-4057qib7 5774 1 Ductopenia Ductopenia NNP cord-005453-4057qib7 5774 2 may may MD cord-005453-4057qib7 5774 3 be be VB cord-005453-4057qib7 5774 4 caused cause VBN cord-005453-4057qib7 5774 5 in in IN cord-005453-4057qib7 5774 6 the the DT cord-005453-4057qib7 5774 7 first first JJ cord-005453-4057qib7 5774 8 place place NN cord-005453-4057qib7 5774 9 by by IN cord-005453-4057qib7 5774 10 chemotherapy chemotherapy NN cord-005453-4057qib7 5774 11 treatment treatment NN cord-005453-4057qib7 5774 12 received receive VBN cord-005453-4057qib7 5774 13 before before IN cord-005453-4057qib7 5774 14 HSCT HSCT NNP cord-005453-4057qib7 5774 15 and and CC cord-005453-4057qib7 5774 16 myeloablative myeloablative JJ cord-005453-4057qib7 5774 17 conditioning conditioning NN cord-005453-4057qib7 5774 18 for for IN cord-005453-4057qib7 5774 19 HSCT HSCT NNP cord-005453-4057qib7 5775 1 and and CC cord-005453-4057qib7 5775 2 it -PRON- PRP cord-005453-4057qib7 5775 3 's be VBZ cord-005453-4057qib7 5775 4 not not RB cord-005453-4057qib7 5775 5 related relate VBN cord-005453-4057qib7 5775 6 with with IN cord-005453-4057qib7 5775 7 GVHD GVHD NNP cord-005453-4057qib7 5775 8 . . . cord-005453-4057qib7 5776 1 This this DT cord-005453-4057qib7 5776 2 hypothesis hypothesis NN cord-005453-4057qib7 5776 3 is be VBZ cord-005453-4057qib7 5776 4 strengthened strengthen VBN cord-005453-4057qib7 5776 5 by by IN cord-005453-4057qib7 5776 6 the the DT cord-005453-4057qib7 5776 7 subgroup subgroup NN cord-005453-4057qib7 5776 8 analysis analysis NN cord-005453-4057qib7 5776 9 of of IN cord-005453-4057qib7 5776 10 pre pre JJ cord-005453-4057qib7 5776 11 - - JJ cord-005453-4057qib7 5776 12 HSCT hsct JJ cord-005453-4057qib7 5776 13 biopsy biopsy NN cord-005453-4057qib7 5776 14 . . . cord-005453-4057qib7 5777 1 Background background NN cord-005453-4057qib7 5777 2 : : : cord-005453-4057qib7 5778 1 Second second JJ cord-005453-4057qib7 5778 2 and and CC cord-005453-4057qib7 5778 3 third third JJ cord-005453-4057qib7 5778 4 line line NN cord-005453-4057qib7 5778 5 therapies therapy NNS cord-005453-4057qib7 5778 6 for for IN cord-005453-4057qib7 5778 7 steroid steroid NN cord-005453-4057qib7 5778 8 refractory refractory JJ cord-005453-4057qib7 5778 9 acute acute JJ cord-005453-4057qib7 5778 10 Graft graft NN cord-005453-4057qib7 5778 11 versus versus IN cord-005453-4057qib7 5778 12 Host Host NNP cord-005453-4057qib7 5778 13 disease disease NN cord-005453-4057qib7 5778 14 ( ( -LRB- cord-005453-4057qib7 5778 15 aGvHD agvhd NN cord-005453-4057qib7 5778 16 ) ) -RRB- cord-005453-4057qib7 5778 17 after after IN cord-005453-4057qib7 5778 18 allogeneic allogeneic NN cord-005453-4057qib7 5778 19 stem stem NN cord-005453-4057qib7 5778 20 cell cell NN cord-005453-4057qib7 5778 21 transplantation transplantation NN cord-005453-4057qib7 5778 22 ( ( -LRB- cord-005453-4057qib7 5778 23 ASCT ASCT NNP cord-005453-4057qib7 5778 24 ) ) -RRB- cord-005453-4057qib7 5778 25 are be VBP cord-005453-4057qib7 5778 26 still still RB cord-005453-4057qib7 5778 27 lacking lack VBG cord-005453-4057qib7 5778 28 . . . cord-005453-4057qib7 5779 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5779 2 , , , cord-005453-4057qib7 5779 3 a a DT cord-005453-4057qib7 5779 4 selective selective JJ cord-005453-4057qib7 5779 5 Januskinase Januskinase NNP cord-005453-4057qib7 5779 6 1/2 1/2 CD cord-005453-4057qib7 5779 7 inhibitor inhibitor NN cord-005453-4057qib7 5779 8 could could MD cord-005453-4057qib7 5779 9 show show VB cord-005453-4057qib7 5779 10 high high JJ cord-005453-4057qib7 5779 11 efficacy efficacy NN cord-005453-4057qib7 5779 12 in in IN cord-005453-4057qib7 5779 13 aGvHD agvhd NN cord-005453-4057qib7 5779 14 , , , cord-005453-4057qib7 5779 15 as as RB cord-005453-4057qib7 5779 16 well well RB cord-005453-4057qib7 5779 17 as as IN cord-005453-4057qib7 5779 18 Extracorporeal Extracorporeal NNP cord-005453-4057qib7 5779 19 Photopheresis Photopheresis NNP cord-005453-4057qib7 5779 20 ( ( -LRB- cord-005453-4057qib7 5779 21 ECP ECP NNP cord-005453-4057qib7 5779 22 ) ) -RRB- cord-005453-4057qib7 5779 23 . . . cord-005453-4057qib7 5780 1 Here here RB cord-005453-4057qib7 5780 2 we -PRON- PRP cord-005453-4057qib7 5780 3 report report VBP cord-005453-4057qib7 5780 4 a a DT cord-005453-4057qib7 5780 5 single single JJ cord-005453-4057qib7 5780 6 center center NN cord-005453-4057qib7 5780 7 experience experience NN cord-005453-4057qib7 5780 8 of of IN cord-005453-4057qib7 5780 9 combining combine VBG cord-005453-4057qib7 5780 10 both both DT cord-005453-4057qib7 5780 11 therapeutic therapeutic JJ cord-005453-4057qib7 5780 12 approaches approach NNS cord-005453-4057qib7 5780 13 in in IN cord-005453-4057qib7 5780 14 severe severe JJ cord-005453-4057qib7 5780 15 steroid steroid NN cord-005453-4057qib7 5780 16 refractory refractory JJ cord-005453-4057qib7 5780 17 aGvHD agvhd NN cord-005453-4057qib7 5780 18 with with IN cord-005453-4057qib7 5780 19 additional additional JJ cord-005453-4057qib7 5780 20 analysis analysis NN cord-005453-4057qib7 5780 21 of of IN cord-005453-4057qib7 5780 22 immune immune JJ cord-005453-4057qib7 5780 23 status status NN cord-005453-4057qib7 5780 24 of of IN cord-005453-4057qib7 5780 25 these these DT cord-005453-4057qib7 5780 26 patients patient NNS cord-005453-4057qib7 5780 27 to to TO cord-005453-4057qib7 5780 28 elucidate elucidate VB cord-005453-4057qib7 5780 29 direct direct JJ cord-005453-4057qib7 5780 30 effects effect NNS cord-005453-4057qib7 5780 31 of of IN cord-005453-4057qib7 5780 32 this this DT cord-005453-4057qib7 5780 33 treatment treatment NN cord-005453-4057qib7 5780 34 on on IN cord-005453-4057qib7 5780 35 immune immune JJ cord-005453-4057qib7 5780 36 response response NN cord-005453-4057qib7 5780 37 . . . cord-005453-4057qib7 5781 1 Methods method NNS cord-005453-4057qib7 5781 2 : : : cord-005453-4057qib7 5781 3 From from IN cord-005453-4057qib7 5781 4 June June NNP cord-005453-4057qib7 5781 5 2015 2015 CD cord-005453-4057qib7 5781 6 to to IN cord-005453-4057qib7 5781 7 February February NNP cord-005453-4057qib7 5781 8 2017 2017 CD cord-005453-4057qib7 5781 9 , , , cord-005453-4057qib7 5781 10 18 18 CD cord-005453-4057qib7 5781 11 patients patient NNS cord-005453-4057qib7 5781 12 ( ( -LRB- cord-005453-4057qib7 5781 13 77.8 77.8 CD cord-005453-4057qib7 5781 14 % % NN cord-005453-4057qib7 5781 15 male male NN cord-005453-4057qib7 5781 16 , , , cord-005453-4057qib7 5781 17 22.2 22.2 CD cord-005453-4057qib7 5781 18 % % NN cord-005453-4057qib7 5781 19 female female JJ cord-005453-4057qib7 5781 20 , , , cord-005453-4057qib7 5781 21 median median JJ cord-005453-4057qib7 5781 22 age age NN cord-005453-4057qib7 5781 23 : : : cord-005453-4057qib7 5781 24 58.5 58.5 CD cord-005453-4057qib7 5781 25 years year NNS cord-005453-4057qib7 5781 26 , , , cord-005453-4057qib7 5781 27 r r NN cord-005453-4057qib7 5781 28 : : : cord-005453-4057qib7 5781 29 21 21 CD cord-005453-4057qib7 5781 30 - - SYM cord-005453-4057qib7 5781 31 73 73 CD cord-005453-4057qib7 5781 32 ) ) -RRB- cord-005453-4057qib7 5781 33 with with IN cord-005453-4057qib7 5781 34 steroid steroid NN cord-005453-4057qib7 5781 35 refractory refractory JJ cord-005453-4057qib7 5781 36 aGvHD agvhd NN cord-005453-4057qib7 5781 37 of of IN cord-005453-4057qib7 5781 38 lower low JJR cord-005453-4057qib7 5781 39 GI gi NN cord-005453-4057qib7 5781 40 - - HYPH cord-005453-4057qib7 5781 41 tract tract NN cord-005453-4057qib7 5781 42 after after IN cord-005453-4057qib7 5781 43 ASCT ASCT NNP cord-005453-4057qib7 5781 44 were be VBD cord-005453-4057qib7 5781 45 treated treat VBN cord-005453-4057qib7 5781 46 with with IN cord-005453-4057qib7 5781 47 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5781 48 and and CC cord-005453-4057qib7 5781 49 Extracorporeal extracorporeal JJ cord-005453-4057qib7 5781 50 photopheresis photopheresis NN cord-005453-4057qib7 5781 51 as as IN cord-005453-4057qib7 5781 52 third third JJ cord-005453-4057qib7 5781 53 , , , cord-005453-4057qib7 5781 54 fourth fourth JJ cord-005453-4057qib7 5781 55 or or CC cord-005453-4057qib7 5781 56 fifth fifth JJ cord-005453-4057qib7 5781 57 line line NN cord-005453-4057qib7 5781 58 therapy therapy NN cord-005453-4057qib7 5781 59 . . . cord-005453-4057qib7 5782 1 Some some DT cord-005453-4057qib7 5782 2 patients patient NNS cord-005453-4057qib7 5782 3 showed show VBD cord-005453-4057qib7 5782 4 additional additional JJ cord-005453-4057qib7 5782 5 aGvHD agvhd NN cord-005453-4057qib7 5782 6 of of IN cord-005453-4057qib7 5782 7 skin skin NN cord-005453-4057qib7 5782 8 ( ( -LRB- cord-005453-4057qib7 5782 9 n=7 n=7 NNS cord-005453-4057qib7 5782 10 ) ) -RRB- cord-005453-4057qib7 5782 11 , , , cord-005453-4057qib7 5782 12 liver liver NN cord-005453-4057qib7 5782 13 ( ( -LRB- cord-005453-4057qib7 5782 14 n=6 n=6 NNP cord-005453-4057qib7 5782 15 ) ) -RRB- cord-005453-4057qib7 5782 16 or or CC cord-005453-4057qib7 5782 17 upper upper JJ cord-005453-4057qib7 5782 18 GI gi NN cord-005453-4057qib7 5782 19 - - HYPH cord-005453-4057qib7 5782 20 tract tract NN cord-005453-4057qib7 5782 21 ( ( -LRB- cord-005453-4057qib7 5782 22 n=2 n=2 NNS cord-005453-4057qib7 5782 23 ) ) -RRB- cord-005453-4057qib7 5782 24 . . . cord-005453-4057qib7 5783 1 All all DT cord-005453-4057qib7 5783 2 patients patient NNS cord-005453-4057qib7 5783 3 had have VBD cord-005453-4057qib7 5783 4 an an DT cord-005453-4057qib7 5783 5 overall overall JJ cord-005453-4057qib7 5783 6 grade grade NN cord-005453-4057qib7 5783 7 III III NNP cord-005453-4057qib7 5783 8 ( ( -LRB- cord-005453-4057qib7 5783 9 50 50 CD cord-005453-4057qib7 5783 10 % % NN cord-005453-4057qib7 5783 11 ) ) -RRB- cord-005453-4057qib7 5783 12 or or CC cord-005453-4057qib7 5783 13 IV IV NNP cord-005453-4057qib7 5783 14 aGvHD aGvHD . cord-005453-4057qib7 5783 15 ( ( -LRB- cord-005453-4057qib7 5783 16 50 50 CD cord-005453-4057qib7 5783 17 % % NN cord-005453-4057qib7 5783 18 ) ) -RRB- cord-005453-4057qib7 5783 19 . . . cord-005453-4057qib7 5784 1 Steroid steroid JJ cord-005453-4057qib7 5784 2 refractoriness refractoriness NN cord-005453-4057qib7 5784 3 was be VBD cord-005453-4057qib7 5784 4 defined define VBN cord-005453-4057qib7 5784 5 as as IN cord-005453-4057qib7 5784 6 no no DT cord-005453-4057qib7 5784 7 improvement improvement NN cord-005453-4057qib7 5784 8 in in IN cord-005453-4057qib7 5784 9 7 7 CD cord-005453-4057qib7 5784 10 days day NNS cord-005453-4057qib7 5784 11 or or CC cord-005453-4057qib7 5784 12 aggravation aggravation NN cord-005453-4057qib7 5784 13 after after IN cord-005453-4057qib7 5784 14 5 5 CD cord-005453-4057qib7 5784 15 days day NNS cord-005453-4057qib7 5784 16 of of IN cord-005453-4057qib7 5784 17 steroid steroid NN cord-005453-4057qib7 5784 18 treatment treatment NN cord-005453-4057qib7 5784 19 . . . cord-005453-4057qib7 5785 1 Median median JJ cord-005453-4057qib7 5785 2 start start NN cord-005453-4057qib7 5785 3 of of IN cord-005453-4057qib7 5785 4 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5785 5 or or CC cord-005453-4057qib7 5785 6 ECP ECP NNP cord-005453-4057qib7 5785 7 was be VBD cord-005453-4057qib7 5785 8 day day NN cord-005453-4057qib7 5785 9 86.5 86.5 CD cord-005453-4057qib7 5785 10 after after IN cord-005453-4057qib7 5785 11 ASCT ASCT NNP cord-005453-4057qib7 5786 1 ( ( -LRB- cord-005453-4057qib7 5786 2 r r NN cord-005453-4057qib7 5786 3 : : : cord-005453-4057qib7 5786 4 35 35 CD cord-005453-4057qib7 5786 5 - - SYM cord-005453-4057qib7 5786 6 257 257 CD cord-005453-4057qib7 5786 7 ) ) -RRB- cord-005453-4057qib7 5786 8 . . . cord-005453-4057qib7 5787 1 Medianduration Medianduration NNP cord-005453-4057qib7 5787 2 of of IN cord-005453-4057qib7 5787 3 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5787 4 therapy therapy NN cord-005453-4057qib7 5787 5 was be VBD cord-005453-4057qib7 5787 6 59.8 59.8 CD cord-005453-4057qib7 5787 7 days day NNS cord-005453-4057qib7 5788 1 ( ( -LRB- cord-005453-4057qib7 5788 2 r r NN cord-005453-4057qib7 5788 3 : : : cord-005453-4057qib7 5788 4 14 14 CD cord-005453-4057qib7 5788 5 - - SYM cord-005453-4057qib7 5788 6 192 192 CD cord-005453-4057qib7 5788 7 ) ) -RRB- cord-005453-4057qib7 5788 8 with with IN cord-005453-4057qib7 5788 9 a a DT cord-005453-4057qib7 5788 10 median median JJ cord-005453-4057qib7 5788 11 start start NN cord-005453-4057qib7 5788 12 dosage dosage NN cord-005453-4057qib7 5788 13 of of IN cord-005453-4057qib7 5788 14 20 20 CD cord-005453-4057qib7 5788 15 mg mg NN cord-005453-4057qib7 5788 16 per per IN cord-005453-4057qib7 5788 17 day day NN cord-005453-4057qib7 5788 18 ( ( -LRB- cord-005453-4057qib7 5788 19 2 2 CD cord-005453-4057qib7 5788 20 x x SYM cord-005453-4057qib7 5788 21 10 10 CD cord-005453-4057qib7 5788 22 mg mg NN cord-005453-4057qib7 5788 23 ; ; : cord-005453-4057qib7 5788 24 r r NN cord-005453-4057qib7 5788 25 : : : cord-005453-4057qib7 5788 26 10 10 CD cord-005453-4057qib7 5788 27 - - SYM cord-005453-4057qib7 5788 28 20 20 CD cord-005453-4057qib7 5788 29 mg mg NNP cord-005453-4057qib7 5788 30 ) ) -RRB- cord-005453-4057qib7 5788 31 . . . cord-005453-4057qib7 5789 1 All all DT cord-005453-4057qib7 5789 2 patients patient NNS cord-005453-4057qib7 5789 3 started start VBD cord-005453-4057qib7 5789 4 with with IN cord-005453-4057qib7 5789 5 2 2 CD cord-005453-4057qib7 5789 6 ECP ECP NNP cord-005453-4057qib7 5789 7 treatments treatment NNS cord-005453-4057qib7 5789 8 per per IN cord-005453-4057qib7 5789 9 week week NN cord-005453-4057qib7 5789 10 with with IN cord-005453-4057qib7 5789 11 an an DT cord-005453-4057qib7 5789 12 individual individual JJ cord-005453-4057qib7 5789 13 reduction reduction NN cord-005453-4057qib7 5789 14 of of IN cord-005453-4057qib7 5789 15 treatment treatment NN cord-005453-4057qib7 5789 16 frequency frequency NN cord-005453-4057qib7 5789 17 . . . cord-005453-4057qib7 5790 1 Median median JJ cord-005453-4057qib7 5790 2 number number NN cord-005453-4057qib7 5790 3 of of IN cord-005453-4057qib7 5790 4 ECP ECP NNP cord-005453-4057qib7 5790 5 treatments treatment NNS cord-005453-4057qib7 5790 6 was be VBD cord-005453-4057qib7 5790 7 20.5 20.5 CD cord-005453-4057qib7 5790 8 ( ( -LRB- cord-005453-4057qib7 5790 9 r r NN cord-005453-4057qib7 5790 10 : : : cord-005453-4057qib7 5790 11 2 2 CD cord-005453-4057qib7 5790 12 - - SYM cord-005453-4057qib7 5790 13 71 71 CD cord-005453-4057qib7 5790 14 ) ) -RRB- cord-005453-4057qib7 5790 15 with with IN cord-005453-4057qib7 5790 16 a a DT cord-005453-4057qib7 5790 17 median median JJ cord-005453-4057qib7 5790 18 frequency frequency NN cord-005453-4057qib7 5790 19 of of IN cord-005453-4057qib7 5790 20 ECP ECP NNP cord-005453-4057qib7 5790 21 therapy therapy NN cord-005453-4057qib7 5791 1 once once RB cord-005453-4057qib7 5791 2 a a DT cord-005453-4057qib7 5791 3 week week NN cord-005453-4057qib7 5792 1 ( ( -LRB- cord-005453-4057qib7 5792 2 r r NN cord-005453-4057qib7 5792 3 : : : cord-005453-4057qib7 5792 4 0.5 0.5 CD cord-005453-4057qib7 5792 5 - - HYPH cord-005453-4057qib7 5792 6 2.1 2.1 CD cord-005453-4057qib7 5792 7 ) ) -RRB- cord-005453-4057qib7 5792 8 . . . cord-005453-4057qib7 5793 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 5793 2 ( ( -LRB- cord-005453-4057qib7 5793 3 CMV CMV NNP cord-005453-4057qib7 5793 4 ) ) -RRB- cord-005453-4057qib7 5793 5 status status NN cord-005453-4057qib7 5793 6 of of IN cord-005453-4057qib7 5793 7 all all DT cord-005453-4057qib7 5793 8 patients patient NNS cord-005453-4057qib7 5793 9 and and CC cord-005453-4057qib7 5793 10 immune immune JJ cord-005453-4057qib7 5793 11 status status NN cord-005453-4057qib7 5793 12 of of IN cord-005453-4057qib7 5793 13 ten ten CD cord-005453-4057qib7 5793 14 patients patient NNS cord-005453-4057qib7 5793 15 ( ( -LRB- cord-005453-4057qib7 5793 16 lymphocyte lymphocyte NN cord-005453-4057qib7 5793 17 count count NN cord-005453-4057qib7 5793 18 with with IN cord-005453-4057qib7 5793 19 CD4 CD4 NNP cord-005453-4057qib7 5793 20 + + CC cord-005453-4057qib7 5793 21 T t NN cord-005453-4057qib7 5793 22 helper helper NN cord-005453-4057qib7 5793 23 lymphocyte lymphocyte NN cord-005453-4057qib7 5793 24 and and CC cord-005453-4057qib7 5793 25 regulatory regulatory JJ cord-005453-4057qib7 5793 26 T T NNP cord-005453-4057qib7 5793 27 cell cell NN cord-005453-4057qib7 5793 28 count count NN cord-005453-4057qib7 5793 29 ) ) -RRB- cord-005453-4057qib7 5793 30 were be VBD cord-005453-4057qib7 5793 31 collected collect VBN cord-005453-4057qib7 5793 32 previously previously RB cord-005453-4057qib7 5793 33 , , , cord-005453-4057qib7 5793 34 after after IN cord-005453-4057qib7 5793 35 four four CD cord-005453-4057qib7 5793 36 weeks week NNS cord-005453-4057qib7 5793 37 of of IN cord-005453-4057qib7 5793 38 starting start VBG cord-005453-4057qib7 5793 39 combined combine VBN cord-005453-4057qib7 5793 40 treatment treatment NN cord-005453-4057qib7 5793 41 and and CC cord-005453-4057qib7 5793 42 four four CD cord-005453-4057qib7 5793 43 weeks week NNS cord-005453-4057qib7 5793 44 after after IN cord-005453-4057qib7 5793 45 stopping stop VBG cord-005453-4057qib7 5793 46 the the DT cord-005453-4057qib7 5793 47 treatment treatment NN cord-005453-4057qib7 5793 48 . . . cord-005453-4057qib7 5794 1 Results result NNS cord-005453-4057qib7 5794 2 : : : cord-005453-4057qib7 5795 1 One one CD cord-005453-4057qib7 5795 2 - - HYPH cord-005453-4057qib7 5795 3 year year NN cord-005453-4057qib7 5795 4 estimated estimate VBN cord-005453-4057qib7 5795 5 overall overall JJ cord-005453-4057qib7 5795 6 survival survival NN cord-005453-4057qib7 5795 7 ( ( -LRB- cord-005453-4057qib7 5795 8 OS OS NNP cord-005453-4057qib7 5795 9 ) ) -RRB- cord-005453-4057qib7 5795 10 of of IN cord-005453-4057qib7 5795 11 all all DT cord-005453-4057qib7 5795 12 patients patient NNS cord-005453-4057qib7 5795 13 was be VBD cord-005453-4057qib7 5795 14 50 50 CD cord-005453-4057qib7 5795 15 % % NN cord-005453-4057qib7 5795 16 with with IN cord-005453-4057qib7 5795 17 a a DT cord-005453-4057qib7 5795 18 median median JJ cord-005453-4057qib7 5795 19 estimated estimate VBN cord-005453-4057qib7 5795 20 OS os NN cord-005453-4057qib7 5795 21 of of IN cord-005453-4057qib7 5795 22 314 314 CD cord-005453-4057qib7 5795 23 days day NNS cord-005453-4057qib7 5795 24 . . . cord-005453-4057qib7 5796 1 3 3 CD cord-005453-4057qib7 5796 2 patients patient NNS cord-005453-4057qib7 5796 3 died die VBD cord-005453-4057qib7 5796 4 because because IN cord-005453-4057qib7 5796 5 of of IN cord-005453-4057qib7 5796 6 relapse relapse NN cord-005453-4057qib7 5796 7 of of IN cord-005453-4057qib7 5796 8 underlying underlie VBG cord-005453-4057qib7 5796 9 disease disease NN cord-005453-4057qib7 5796 10 , , , cord-005453-4057qib7 5796 11 one one CD cord-005453-4057qib7 5796 12 of of IN cord-005453-4057qib7 5796 13 severe severe JJ cord-005453-4057qib7 5796 14 therapy therapy NN cord-005453-4057qib7 5796 15 refractory refractory JJ cord-005453-4057qib7 5796 16 aGvHD agvhd NN cord-005453-4057qib7 5796 17 of of IN cord-005453-4057qib7 5796 18 lower low JJR cord-005453-4057qib7 5796 19 GI GI NNP cord-005453-4057qib7 5796 20 tract tract NN cord-005453-4057qib7 5796 21 and and CC cord-005453-4057qib7 5796 22 5 5 CD cord-005453-4057qib7 5796 23 due due IN cord-005453-4057qib7 5796 24 to to IN cord-005453-4057qib7 5796 25 infection infection NN cord-005453-4057qib7 5796 26 complications complication NNS cord-005453-4057qib7 5796 27 in in IN cord-005453-4057qib7 5796 28 aGvHD agvhd NN cord-005453-4057qib7 5796 29 refractory refractory JJ cord-005453-4057qib7 5796 30 setting setting NN cord-005453-4057qib7 5796 31 . . . cord-005453-4057qib7 5797 1 Overall overall JJ cord-005453-4057qib7 5797 2 response response NN cord-005453-4057qib7 5797 3 was be VBD cord-005453-4057qib7 5797 4 55.5 55.5 CD cord-005453-4057qib7 5797 5 % % NN cord-005453-4057qib7 5797 6 ( ( -LRB- cord-005453-4057qib7 5797 7 complete complete JJ cord-005453-4057qib7 5797 8 remission remission NN cord-005453-4057qib7 5797 9 rate rate NN cord-005453-4057qib7 5797 10 : : : cord-005453-4057qib7 5797 11 44.4 44.4 CD cord-005453-4057qib7 5797 12 % % NN cord-005453-4057qib7 5797 13 , , , cord-005453-4057qib7 5797 14 partial partial JJ cord-005453-4057qib7 5797 15 remission remission NN cord-005453-4057qib7 5797 16 rate rate NN cord-005453-4057qib7 5797 17 : : : cord-005453-4057qib7 5797 18 11.1 11.1 CD cord-005453-4057qib7 5797 19 % % NN cord-005453-4057qib7 5797 20 ) ) -RRB- cord-005453-4057qib7 5797 21 . . . cord-005453-4057qib7 5798 1 72.2 72.2 CD cord-005453-4057qib7 5798 2 % % NN cord-005453-4057qib7 5798 3 ( ( -LRB- cord-005453-4057qib7 5798 4 n=13 n=13 NNP cord-005453-4057qib7 5798 5 ) ) -RRB- cord-005453-4057qib7 5798 6 of of IN cord-005453-4057qib7 5798 7 the the DT cord-005453-4057qib7 5798 8 patients patient NNS cord-005453-4057qib7 5798 9 had have VBD cord-005453-4057qib7 5798 10 cytopenia cytopenia VBN cord-005453-4057qib7 5798 11 CTC CTC NNP cord-005453-4057qib7 5798 12 I I NNP cord-005453-4057qib7 5798 13 - - HYPH cord-005453-4057qib7 5798 14 III III NNP cord-005453-4057qib7 5798 15 during during IN cord-005453-4057qib7 5798 16 the the DT cord-005453-4057qib7 5798 17 treatment treatment NN cord-005453-4057qib7 5798 18 , , , cord-005453-4057qib7 5798 19 no no DT cord-005453-4057qib7 5798 20 grade grade NN cord-005453-4057qib7 5798 21 IV IV NNP cord-005453-4057qib7 5798 22 cytopenia cytopenia NNP cord-005453-4057qib7 5798 23 was be VBD cord-005453-4057qib7 5798 24 reported report VBN cord-005453-4057qib7 5798 25 . . . cord-005453-4057qib7 5799 1 CMV CMV NNP cord-005453-4057qib7 5799 2 reactivation reactivation NN cord-005453-4057qib7 5799 3 during during IN cord-005453-4057qib7 5799 4 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5799 5 occured occur VBD cord-005453-4057qib7 5799 6 in in IN cord-005453-4057qib7 5799 7 66.7 66.7 CD cord-005453-4057qib7 5799 8 % % NN cord-005453-4057qib7 5799 9 of of IN cord-005453-4057qib7 5799 10 cases case NNS cord-005453-4057qib7 5799 11 ( ( -LRB- cord-005453-4057qib7 5799 12 n=12 n=12 NNP cord-005453-4057qib7 5799 13 ) ) -RRB- cord-005453-4057qib7 5799 14 . . . cord-005453-4057qib7 5800 1 Tapering taper VBG cord-005453-4057qib7 5800 2 of of IN cord-005453-4057qib7 5800 3 steroids steroid NNS cord-005453-4057qib7 5800 4 could could MD cord-005453-4057qib7 5800 5 be be VB cord-005453-4057qib7 5800 6 performed perform VBN cord-005453-4057qib7 5800 7 rapidly rapidly RB cord-005453-4057qib7 5800 8 with with IN cord-005453-4057qib7 5800 9 a a DT cord-005453-4057qib7 5800 10 medium medium JJ cord-005453-4057qib7 5800 11 reduction reduction NN cord-005453-4057qib7 5800 12 time time NN cord-005453-4057qib7 5800 13 of of IN cord-005453-4057qib7 5800 14 1.75 1.75 CD cord-005453-4057qib7 5800 15 days day NNS cord-005453-4057qib7 5800 16 for for IN cord-005453-4057qib7 5800 17 reducing reduce VBG cord-005453-4057qib7 5800 18 to to IN cord-005453-4057qib7 5800 19 half half NN cord-005453-4057qib7 5800 20 of of IN cord-005453-4057qib7 5800 21 the the DT cord-005453-4057qib7 5800 22 dosage dosage NN cord-005453-4057qib7 5800 23 . . . cord-005453-4057qib7 5801 1 Remarkably remarkably RB cord-005453-4057qib7 5801 2 , , , cord-005453-4057qib7 5801 3 regulatory regulatory JJ cord-005453-4057qib7 5801 4 T t NN cord-005453-4057qib7 5801 5 cells cell NNS cord-005453-4057qib7 5801 6 significantly significantly RB cord-005453-4057qib7 5801 7 increased increase VBD cord-005453-4057qib7 5801 8 during during IN cord-005453-4057qib7 5801 9 combined combine VBN cord-005453-4057qib7 5801 10 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5801 11 / / SYM cord-005453-4057qib7 5801 12 ECP ECP NNP cord-005453-4057qib7 5801 13 treatment treatment NN cord-005453-4057qib7 5801 14 compared compare VBN cord-005453-4057qib7 5801 15 to to IN cord-005453-4057qib7 5801 16 regulatory regulatory JJ cord-005453-4057qib7 5801 17 T t NN cord-005453-4057qib7 5801 18 cell cell NN cord-005453-4057qib7 5801 19 count count NN cord-005453-4057qib7 5801 20 before before IN cord-005453-4057qib7 5801 21 treatment treatment NN cord-005453-4057qib7 5801 22 ( ( -LRB- cord-005453-4057qib7 5801 23 p=0.02 p=0.02 NN cord-005453-4057qib7 5801 24 ) ) -RRB- cord-005453-4057qib7 5801 25 and and CC cord-005453-4057qib7 5801 26 after after IN cord-005453-4057qib7 5801 27 stopping stop VBG cord-005453-4057qib7 5801 28 treatment treatment NN cord-005453-4057qib7 5801 29 , , , cord-005453-4057qib7 5801 30 regulatory regulatory JJ cord-005453-4057qib7 5801 31 T t NN cord-005453-4057qib7 5801 32 cell cell NN cord-005453-4057qib7 5801 33 count count NN cord-005453-4057qib7 5801 34 decreased decrease VBD cord-005453-4057qib7 5801 35 again again RB cord-005453-4057qib7 5802 1 ( ( -LRB- cord-005453-4057qib7 5802 2 p=0.02 p=0.02 JJ cord-005453-4057qib7 5802 3 , , , cord-005453-4057qib7 5802 4 see see VB cord-005453-4057qib7 5802 5 figure figure NN cord-005453-4057qib7 5802 6 ) ) -RRB- cord-005453-4057qib7 5802 7 . . . cord-005453-4057qib7 5803 1 Significant significant JJ cord-005453-4057qib7 5803 2 changes change NNS cord-005453-4057qib7 5803 3 in in IN cord-005453-4057qib7 5803 4 whole whole JJ cord-005453-4057qib7 5803 5 lymphocyte lymphocyte NN cord-005453-4057qib7 5803 6 count count NN cord-005453-4057qib7 5803 7 or or CC cord-005453-4057qib7 5803 8 in in IN cord-005453-4057qib7 5803 9 CD4 CD4 NNP cord-005453-4057qib7 5803 10 + + CC cord-005453-4057qib7 5803 11 T T NNP cord-005453-4057qib7 5803 12 helper helper NN cord-005453-4057qib7 5803 13 cell cell NN cord-005453-4057qib7 5803 14 count count NN cord-005453-4057qib7 5803 15 were be VBD cord-005453-4057qib7 5803 16 not not RB cord-005453-4057qib7 5803 17 observed observe VBN cord-005453-4057qib7 5803 18 . . . cord-005453-4057qib7 5804 1 Conclusions conclusion NNS cord-005453-4057qib7 5804 2 : : : cord-005453-4057qib7 5805 1 Treatment treatment NN cord-005453-4057qib7 5805 2 of of IN cord-005453-4057qib7 5805 3 severe severe JJ cord-005453-4057qib7 5805 4 steroid steroid NN cord-005453-4057qib7 5805 5 refractory refractory JJ cord-005453-4057qib7 5805 6 aGvHD agvhd NN cord-005453-4057qib7 5805 7 with with IN cord-005453-4057qib7 5805 8 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5805 9 plus plus CC cord-005453-4057qib7 5805 10 ECP ECP NNP cord-005453-4057qib7 5805 11 could could MD cord-005453-4057qib7 5805 12 show show VB cord-005453-4057qib7 5805 13 a a DT cord-005453-4057qib7 5805 14 high high JJ cord-005453-4057qib7 5805 15 complete complete JJ cord-005453-4057qib7 5805 16 remission remission NN cord-005453-4057qib7 5805 17 rate rate NN cord-005453-4057qib7 5805 18 of of IN cord-005453-4057qib7 5805 19 44.4 44.4 CD cord-005453-4057qib7 5805 20 % % NN cord-005453-4057qib7 5805 21 with with IN cord-005453-4057qib7 5805 22 an an DT cord-005453-4057qib7 5805 23 one one CD cord-005453-4057qib7 5805 24 year year NN cord-005453-4057qib7 5805 25 OS os NN cord-005453-4057qib7 5805 26 of of IN cord-005453-4057qib7 5805 27 50 50 CD cord-005453-4057qib7 5805 28 % % NN cord-005453-4057qib7 5805 29 . . . cord-005453-4057qib7 5806 1 Detecting detect VBG cord-005453-4057qib7 5806 2 increased increase VBN cord-005453-4057qib7 5806 3 regulatory regulatory JJ cord-005453-4057qib7 5806 4 T t NN cord-005453-4057qib7 5806 5 cell cell NN cord-005453-4057qib7 5806 6 count count NN cord-005453-4057qib7 5806 7 during during IN cord-005453-4057qib7 5806 8 the the DT cord-005453-4057qib7 5806 9 treatment treatment NN cord-005453-4057qib7 5806 10 underlines underline VBZ cord-005453-4057qib7 5806 11 its -PRON- PRP$ cord-005453-4057qib7 5806 12 direct direct JJ cord-005453-4057qib7 5806 13 effects effect NNS cord-005453-4057qib7 5806 14 on on IN cord-005453-4057qib7 5806 15 immune immune JJ cord-005453-4057qib7 5806 16 response response NN cord-005453-4057qib7 5806 17 and and CC cord-005453-4057qib7 5806 18 encourages encourage VBZ cord-005453-4057qib7 5806 19 to to TO cord-005453-4057qib7 5806 20 pursue pursue VB cord-005453-4057qib7 5806 21 this this DT cord-005453-4057qib7 5806 22 promising promising JJ cord-005453-4057qib7 5806 23 therapeutic therapeutic JJ cord-005453-4057qib7 5806 24 approach approach NN cord-005453-4057qib7 5806 25 . . . cord-005453-4057qib7 5807 1 [ [ -LRB- cord-005453-4057qib7 5807 2 Background background NN cord-005453-4057qib7 5807 3 : : : cord-005453-4057qib7 5807 4 Due due IN cord-005453-4057qib7 5807 5 to to IN cord-005453-4057qib7 5807 6 increased increase VBN cord-005453-4057qib7 5807 7 immunosuppression immunosuppression NN cord-005453-4057qib7 5807 8 infections infection NNS cord-005453-4057qib7 5807 9 remain remain VBP cord-005453-4057qib7 5807 10 the the DT cord-005453-4057qib7 5807 11 main main JJ cord-005453-4057qib7 5807 12 cause cause NN cord-005453-4057qib7 5807 13 of of IN cord-005453-4057qib7 5807 14 death death NN cord-005453-4057qib7 5807 15 followed follow VBN cord-005453-4057qib7 5807 16 by by IN cord-005453-4057qib7 5807 17 higher high JJR cord-005453-4057qib7 5807 18 risk risk NN cord-005453-4057qib7 5807 19 of of IN cord-005453-4057qib7 5807 20 relapse relapse NN cord-005453-4057qib7 5807 21 in in IN cord-005453-4057qib7 5807 22 patients patient NNS cord-005453-4057qib7 5807 23 treated treat VBN cord-005453-4057qib7 5807 24 for for IN cord-005453-4057qib7 5807 25 acute acute JJ cord-005453-4057qib7 5807 26 graft graft NN cord-005453-4057qib7 5807 27 versus versus IN cord-005453-4057qib7 5807 28 host host NN cord-005453-4057qib7 5807 29 disease disease NN cord-005453-4057qib7 5807 30 ( ( -LRB- cord-005453-4057qib7 5807 31 aGvHD agvhd NN cord-005453-4057qib7 5807 32 ) ) -RRB- cord-005453-4057qib7 5807 33 after after IN cord-005453-4057qib7 5807 34 allogeneic allogeneic NN cord-005453-4057qib7 5807 35 stem stem NN cord-005453-4057qib7 5807 36 cell cell NN cord-005453-4057qib7 5807 37 transplant transplant NN cord-005453-4057qib7 5807 38 ( ( -LRB- cord-005453-4057qib7 5807 39 SCT SCT NNP cord-005453-4057qib7 5807 40 ) ) -RRB- cord-005453-4057qib7 5807 41 . . . cord-005453-4057qib7 5808 1 Here here RB cord-005453-4057qib7 5808 2 we -PRON- PRP cord-005453-4057qib7 5808 3 report report VBP cord-005453-4057qib7 5808 4 a a DT cord-005453-4057qib7 5808 5 single single JJ cord-005453-4057qib7 5808 6 - - HYPH cord-005453-4057qib7 5808 7 centre centre NN cord-005453-4057qib7 5808 8 experience experience NN cord-005453-4057qib7 5808 9 with with IN cord-005453-4057qib7 5808 10 extracorporeal extracorporeal JJ cord-005453-4057qib7 5808 11 photopheresis photopheresis NN cord-005453-4057qib7 5808 12 ( ( -LRB- cord-005453-4057qib7 5808 13 ECP ECP NNP cord-005453-4057qib7 5808 14 ) ) -RRB- cord-005453-4057qib7 5808 15 for for IN cord-005453-4057qib7 5808 16 acute acute JJ cord-005453-4057qib7 5808 17 GvHD GvHD NNP cord-005453-4057qib7 5808 18 that that WDT cord-005453-4057qib7 5808 19 was be VBD cord-005453-4057qib7 5808 20 introduced introduce VBN cord-005453-4057qib7 5808 21 in in IN cord-005453-4057qib7 5808 22 order order NN cord-005453-4057qib7 5808 23 to to TO cord-005453-4057qib7 5808 24 reduce reduce VB cord-005453-4057qib7 5808 25 steroid steroid NN cord-005453-4057qib7 5808 26 treatment treatment NN cord-005453-4057qib7 5808 27 . . . cord-005453-4057qib7 5809 1 Comparison comparison NN cord-005453-4057qib7 5809 2 of of IN cord-005453-4057qib7 5809 3 overall overall JJ cord-005453-4057qib7 5809 4 survival survival NN cord-005453-4057qib7 5809 5 ( ( -LRB- cord-005453-4057qib7 5809 6 OS OS NNP cord-005453-4057qib7 5809 7 ) ) -RRB- cord-005453-4057qib7 5809 8 for for IN cord-005453-4057qib7 5809 9 patients patient NNS cord-005453-4057qib7 5809 10 on on IN cord-005453-4057qib7 5809 11 ECP ECP NNP cord-005453-4057qib7 5809 12 and and CC cord-005453-4057qib7 5809 13 patients patient NNS cord-005453-4057qib7 5809 14 that that WDT cord-005453-4057qib7 5809 15 received receive VBD cord-005453-4057qib7 5809 16 standard standard JJ cord-005453-4057qib7 5809 17 first first JJ cord-005453-4057qib7 5809 18 line line NN cord-005453-4057qib7 5809 19 therapy therapy NN cord-005453-4057qib7 5809 20 for for IN cord-005453-4057qib7 5809 21 aGVHD aGVHD NNP cord-005453-4057qib7 5809 22 was be VBD cord-005453-4057qib7 5809 23 performed perform VBN cord-005453-4057qib7 5809 24 . . . cord-005453-4057qib7 5810 1 Methods method NNS cord-005453-4057qib7 5810 2 : : : cord-005453-4057qib7 5810 3 We -PRON- PRP cord-005453-4057qib7 5810 4 retrospectively retrospectively RB cord-005453-4057qib7 5810 5 analysed analyse VBD cord-005453-4057qib7 5810 6 62 62 CD cord-005453-4057qib7 5810 7 patients patient NNS cord-005453-4057qib7 5810 8 ( ( -LRB- cord-005453-4057qib7 5810 9 28 28 CD cord-005453-4057qib7 5810 10 % % NN cord-005453-4057qib7 5810 11 ) ) -RRB- cord-005453-4057qib7 5810 12 with with IN cord-005453-4057qib7 5810 13 acute acute JJ cord-005453-4057qib7 5810 14 GVHD GVHD NNP cord-005453-4057qib7 5810 15 grade grade NN cord-005453-4057qib7 5810 16 II II NNP cord-005453-4057qib7 5810 17 - - HYPH cord-005453-4057qib7 5810 18 IV IV NNP cord-005453-4057qib7 5810 19 treated treat VBN cord-005453-4057qib7 5810 20 from from IN cord-005453-4057qib7 5810 21 January January NNP cord-005453-4057qib7 5810 22 2010 2010 CD cord-005453-4057qib7 5810 23 to to IN cord-005453-4057qib7 5810 24 October October NNP cord-005453-4057qib7 5810 25 2018 2018 CD cord-005453-4057qib7 5810 26 out out IN cord-005453-4057qib7 5810 27 of of IN cord-005453-4057qib7 5810 28 total total JJ cord-005453-4057qib7 5810 29 221 221 CD cord-005453-4057qib7 5810 30 allogeneic allogeneic NN cord-005453-4057qib7 5810 31 SCT SCT NNP cord-005453-4057qib7 5810 32 in in IN cord-005453-4057qib7 5810 33 that that DT cord-005453-4057qib7 5810 34 period period NN cord-005453-4057qib7 5810 35 . . . cord-005453-4057qib7 5811 1 All all DT cord-005453-4057qib7 5811 2 patients patient NNS cord-005453-4057qib7 5811 3 received receive VBD cord-005453-4057qib7 5811 4 calcineurin calcineurin NNP cord-005453-4057qib7 5811 5 inhibitors inhibitor NNS cord-005453-4057qib7 5811 6 or or CC cord-005453-4057qib7 5811 7 sirolimus sirolimus NN cord-005453-4057qib7 5811 8 while while IN cord-005453-4057qib7 5811 9 receiving receive VBG cord-005453-4057qib7 5811 10 steroid steroid NN cord-005453-4057qib7 5811 11 treatment treatment NN cord-005453-4057qib7 5811 12 for for IN cord-005453-4057qib7 5811 13 aGvHD agvhd NN cord-005453-4057qib7 5811 14 . . . cord-005453-4057qib7 5812 1 Twenty twenty CD cord-005453-4057qib7 5812 2 - - HYPH cord-005453-4057qib7 5812 3 five five CD cord-005453-4057qib7 5812 4 patients patient NNS cord-005453-4057qib7 5812 5 ( ( -LRB- cord-005453-4057qib7 5812 6 40 40 CD cord-005453-4057qib7 5812 7 % % NN cord-005453-4057qib7 5812 8 ) ) -RRB- cord-005453-4057qib7 5812 9 received receive VBD cord-005453-4057qib7 5812 10 ECP ECP NNP cord-005453-4057qib7 5812 11 with with IN cord-005453-4057qib7 5812 12 steroid steroid NN cord-005453-4057qib7 5812 13 lowering lower VBG cord-005453-4057qib7 5812 14 intent intent NN cord-005453-4057qib7 5812 15 . . . cord-005453-4057qib7 5813 1 We -PRON- PRP cord-005453-4057qib7 5813 2 defined define VBD cord-005453-4057qib7 5813 3 response response NN cord-005453-4057qib7 5813 4 as as IN cord-005453-4057qib7 5813 5 ( ( -LRB- cord-005453-4057qib7 5813 6 1 1 CD cord-005453-4057qib7 5813 7 ) ) -RRB- cord-005453-4057qib7 5813 8 reduction reduction NN cord-005453-4057qib7 5813 9 of of IN cord-005453-4057qib7 5813 10 steroid steroid NN cord-005453-4057qib7 5813 11 dose dose NN cord-005453-4057qib7 5813 12 for for IN cord-005453-4057qib7 5813 13 at at RB cord-005453-4057qib7 5813 14 least least JJS cord-005453-4057qib7 5813 15 50 50 CD cord-005453-4057qib7 5813 16 % % NN cord-005453-4057qib7 5813 17 from from IN cord-005453-4057qib7 5813 18 baseline baseline NN cord-005453-4057qib7 5813 19 while while IN cord-005453-4057qib7 5813 20 not not RB cord-005453-4057qib7 5813 21 adding add VBG cord-005453-4057qib7 5813 22 another another DT cord-005453-4057qib7 5813 23 immunosuppresive immunosuppresive JJ cord-005453-4057qib7 5813 24 agent agent NN cord-005453-4057qib7 5813 25 and and CC cord-005453-4057qib7 5813 26 ( ( -LRB- cord-005453-4057qib7 5813 27 2 2 LS cord-005453-4057qib7 5813 28 ) ) -RRB- cord-005453-4057qib7 5813 29 not not RB cord-005453-4057qib7 5813 30 repeating repeat VBG cord-005453-4057qib7 5813 31 second second JJ cord-005453-4057qib7 5813 32 steroid steroid JJ cord-005453-4057qib7 5813 33 treatment treatment NN cord-005453-4057qib7 5813 34 if if IN cord-005453-4057qib7 5813 35 the the DT cord-005453-4057qib7 5813 36 ECP ECP NNP cord-005453-4057qib7 5813 37 was be VBD cord-005453-4057qib7 5813 38 started start VBN cord-005453-4057qib7 5813 39 after after IN cord-005453-4057qib7 5813 40 lowering lower VBG cord-005453-4057qib7 5813 41 of of IN cord-005453-4057qib7 5813 42 steroids steroid NNS cord-005453-4057qib7 5813 43 to to TO cord-005453-4057qib7 5813 44 prevent prevent VB cord-005453-4057qib7 5813 45 aGVHD aGVHD NNP cord-005453-4057qib7 5813 46 flare flare NN cord-005453-4057qib7 5813 47 . . . cord-005453-4057qib7 5814 1 We -PRON- PRP cord-005453-4057qib7 5814 2 checked check VBD cord-005453-4057qib7 5814 3 separately separately RB cord-005453-4057qib7 5814 4 patient patient JJ cord-005453-4057qib7 5814 5 responsive responsive JJ cord-005453-4057qib7 5814 6 and and CC cord-005453-4057qib7 5814 7 refractory refractory JJ cord-005453-4057qib7 5814 8 / / SYM cord-005453-4057qib7 5814 9 dependent dependent JJ cord-005453-4057qib7 5814 10 to to IN cord-005453-4057qib7 5814 11 steroids steroid NNS cord-005453-4057qib7 5814 12 . . . cord-005453-4057qib7 5815 1 On on IN cord-005453-4057qib7 5815 2 average average JJ cord-005453-4057qib7 5815 3 patients patient NNS cord-005453-4057qib7 5815 4 received receive VBD cord-005453-4057qib7 5815 5 ECP ECP NNP cord-005453-4057qib7 5815 6 procedure procedure NN cord-005453-4057qib7 5815 7 once once RB cord-005453-4057qib7 5815 8 weekly weekly RB cord-005453-4057qib7 5815 9 . . . cord-005453-4057qib7 5816 1 Results result NNS cord-005453-4057qib7 5816 2 : : : cord-005453-4057qib7 5817 1 Tapering taper VBG cord-005453-4057qib7 5817 2 of of IN cord-005453-4057qib7 5817 3 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 5817 4 therapy therapy NN cord-005453-4057qib7 5817 5 as as IN cord-005453-4057qib7 5817 6 defined define VBN cord-005453-4057qib7 5817 7 was be VBD cord-005453-4057qib7 5817 8 successful successful JJ cord-005453-4057qib7 5817 9 in in IN cord-005453-4057qib7 5817 10 13 13 CD cord-005453-4057qib7 5817 11 ( ( -LRB- cord-005453-4057qib7 5817 12 52 52 CD cord-005453-4057qib7 5817 13 % % NN cord-005453-4057qib7 5817 14 ) ) -RRB- cord-005453-4057qib7 5817 15 out out IN cord-005453-4057qib7 5817 16 of of IN cord-005453-4057qib7 5817 17 25 25 CD cord-005453-4057qib7 5817 18 patients patient NNS cord-005453-4057qib7 5817 19 in in IN cord-005453-4057qib7 5817 20 ECP ECP NNP cord-005453-4057qib7 5817 21 group group NN cord-005453-4057qib7 5817 22 . . . cord-005453-4057qib7 5818 1 In in IN cord-005453-4057qib7 5818 2 a a DT cord-005453-4057qib7 5818 3 group group NN cord-005453-4057qib7 5818 4 of of IN cord-005453-4057qib7 5818 5 patients patient NNS cord-005453-4057qib7 5818 6 without without IN cord-005453-4057qib7 5818 7 ECP ECP NNP cord-005453-4057qib7 5818 8 14 14 CD cord-005453-4057qib7 5818 9 ( ( -LRB- cord-005453-4057qib7 5818 10 37 37 CD cord-005453-4057qib7 5818 11 % % NN cord-005453-4057qib7 5818 12 ) ) -RRB- cord-005453-4057qib7 5818 13 patients patient NNS cord-005453-4057qib7 5818 14 had have VBD cord-005453-4057qib7 5818 15 steroid steroid NN cord-005453-4057qib7 5818 16 refractory refractory JJ cord-005453-4057qib7 5818 17 or or CC cord-005453-4057qib7 5818 18 steroid steroid NN cord-005453-4057qib7 5818 19 dependent dependent JJ cord-005453-4057qib7 5818 20 aGVHD agvhd NN cord-005453-4057qib7 5818 21 compared compare VBN cord-005453-4057qib7 5818 22 to to IN cord-005453-4057qib7 5818 23 11 11 CD cord-005453-4057qib7 5818 24 ( ( -LRB- cord-005453-4057qib7 5818 25 44 44 CD cord-005453-4057qib7 5818 26 % % NN cord-005453-4057qib7 5818 27 ) ) -RRB- cord-005453-4057qib7 5818 28 patients patient NNS cord-005453-4057qib7 5818 29 in in IN cord-005453-4057qib7 5818 30 ECP ECP NNP cord-005453-4057qib7 5818 31 group group NN cord-005453-4057qib7 5818 32 . . . cord-005453-4057qib7 5819 1 Four four CD cord-005453-4057qib7 5819 2 ( ( -LRB- cord-005453-4057qib7 5819 3 16 16 CD cord-005453-4057qib7 5819 4 % % NN cord-005453-4057qib7 5819 5 ) ) -RRB- cord-005453-4057qib7 5819 6 patients patient NNS cord-005453-4057qib7 5819 7 with with IN cord-005453-4057qib7 5819 8 steroid steroid NN cord-005453-4057qib7 5819 9 refractory refractory JJ cord-005453-4057qib7 5819 10 or or CC cord-005453-4057qib7 5819 11 dependent dependent JJ cord-005453-4057qib7 5819 12 aGVHD aGVHD NNP cord-005453-4057qib7 5819 13 showed show VBD cord-005453-4057qib7 5819 14 improvement improvement NN cord-005453-4057qib7 5819 15 in in IN cord-005453-4057qib7 5819 16 ECP ECP NNP cord-005453-4057qib7 5819 17 group group NN cord-005453-4057qib7 5819 18 compared compare VBN cord-005453-4057qib7 5819 19 to to IN cord-005453-4057qib7 5819 20 only only RB cord-005453-4057qib7 5819 21 one one CD cord-005453-4057qib7 5819 22 ( ( -LRB- cord-005453-4057qib7 5819 23 2,7 2,7 CD cord-005453-4057qib7 5819 24 % % NN cord-005453-4057qib7 5819 25 ) ) -RRB- cord-005453-4057qib7 5819 26 in in IN cord-005453-4057qib7 5819 27 non non JJ cord-005453-4057qib7 5819 28 ECP ECP NNP cord-005453-4057qib7 5819 29 group group NN cord-005453-4057qib7 5819 30 . . . cord-005453-4057qib7 5820 1 Twenty twenty CD cord-005453-4057qib7 5820 2 ( ( -LRB- cord-005453-4057qib7 5820 3 74 74 CD cord-005453-4057qib7 5820 4 % % NN cord-005453-4057qib7 5820 5 ) ) -RRB- cord-005453-4057qib7 5820 6 patients patient NNS cord-005453-4057qib7 5820 7 died die VBD cord-005453-4057qib7 5820 8 due due JJ cord-005453-4057qib7 5820 9 to to IN cord-005453-4057qib7 5820 10 infectious infectious JJ cord-005453-4057qib7 5820 11 complication complication NN cord-005453-4057qib7 5820 12 and and CC cord-005453-4057qib7 5820 13 7 7 CD cord-005453-4057qib7 5820 14 ( ( -LRB- cord-005453-4057qib7 5820 15 26 26 CD cord-005453-4057qib7 5820 16 % % NN cord-005453-4057qib7 5820 17 ) ) -RRB- cord-005453-4057qib7 5820 18 due due IN cord-005453-4057qib7 5820 19 to to IN cord-005453-4057qib7 5820 20 relapse relapse NN cord-005453-4057qib7 5820 21 in in IN cord-005453-4057qib7 5820 22 non non JJ cord-005453-4057qib7 5820 23 ECP ECP NNP cord-005453-4057qib7 5820 24 cohort cohort NN cord-005453-4057qib7 5820 25 . . . cord-005453-4057qib7 5821 1 In in IN cord-005453-4057qib7 5821 2 ECP ECP NNP cord-005453-4057qib7 5821 3 cohort cohort NN cord-005453-4057qib7 5821 4 10 10 CD cord-005453-4057qib7 5821 5 ( ( -LRB- cord-005453-4057qib7 5821 6 77 77 CD cord-005453-4057qib7 5821 7 % % NN cord-005453-4057qib7 5821 8 ) ) -RRB- cord-005453-4057qib7 5821 9 patients patient NNS cord-005453-4057qib7 5821 10 died die VBD cord-005453-4057qib7 5821 11 due due IN cord-005453-4057qib7 5821 12 to to IN cord-005453-4057qib7 5821 13 infection infection NN cord-005453-4057qib7 5821 14 and and CC cord-005453-4057qib7 5821 15 3 3 CD cord-005453-4057qib7 5821 16 ( ( -LRB- cord-005453-4057qib7 5821 17 23 23 CD cord-005453-4057qib7 5821 18 % % NN cord-005453-4057qib7 5821 19 ) ) -RRB- cord-005453-4057qib7 5821 20 due due IN cord-005453-4057qib7 5821 21 to to IN cord-005453-4057qib7 5821 22 relapse relapse NN cord-005453-4057qib7 5821 23 . . . cord-005453-4057qib7 5822 1 Median median JJ cord-005453-4057qib7 5822 2 OS OS NNP cord-005453-4057qib7 5822 3 was be VBD cord-005453-4057qib7 5822 4 5 5 CD cord-005453-4057qib7 5822 5 months month NNS cord-005453-4057qib7 5822 6 in in IN cord-005453-4057qib7 5822 7 non non JJ cord-005453-4057qib7 5822 8 ECP ECP NNP cord-005453-4057qib7 5822 9 group group NN cord-005453-4057qib7 5822 10 ( ( -LRB- cord-005453-4057qib7 5822 11 r. r. NNP cord-005453-4057qib7 5822 12 , , , cord-005453-4057qib7 5822 13 1 1 CD cord-005453-4057qib7 5822 14 - - SYM cord-005453-4057qib7 5822 15 99 99 CD cord-005453-4057qib7 5822 16 ) ) -RRB- cord-005453-4057qib7 5822 17 compared compare VBN cord-005453-4057qib7 5822 18 to to IN cord-005453-4057qib7 5822 19 21 21 CD cord-005453-4057qib7 5822 20 months month NNS cord-005453-4057qib7 5823 1 ( ( -LRB- cord-005453-4057qib7 5823 2 r. r. NNP cord-005453-4057qib7 5823 3 , , , cord-005453-4057qib7 5823 4 2 2 CD cord-005453-4057qib7 5823 5 - - SYM cord-005453-4057qib7 5823 6 76 76 CD cord-005453-4057qib7 5823 7 ) ) -RRB- cord-005453-4057qib7 5823 8 in in IN cord-005453-4057qib7 5823 9 ECP ECP NNP cord-005453-4057qib7 5823 10 group group NN cord-005453-4057qib7 5823 11 and and CC cord-005453-4057qib7 5823 12 OS os NN cord-005453-4057qib7 5823 13 of of IN cord-005453-4057qib7 5823 14 20 20 CD cord-005453-4057qib7 5823 15 % % NN cord-005453-4057qib7 5823 16 at at IN cord-005453-4057qib7 5823 17 5 5 CD cord-005453-4057qib7 5823 18 years year NNS cord-005453-4057qib7 5823 19 in in IN cord-005453-4057qib7 5823 20 non non JJ cord-005453-4057qib7 5823 21 ECP ECP NNP cord-005453-4057qib7 5823 22 compared compare VBN cord-005453-4057qib7 5823 23 to to IN cord-005453-4057qib7 5823 24 35 35 CD cord-005453-4057qib7 5823 25 % % NN cord-005453-4057qib7 5823 26 in in IN cord-005453-4057qib7 5823 27 ECP ECP NNP cord-005453-4057qib7 5823 28 cohort cohort NN cord-005453-4057qib7 5823 29 was be VBD cord-005453-4057qib7 5823 30 observed observe VBN cord-005453-4057qib7 5823 31 . . . cord-005453-4057qib7 5824 1 Patients patient NNS cord-005453-4057qib7 5824 2 with with IN cord-005453-4057qib7 5824 3 aGvHD agvhd NN cord-005453-4057qib7 5824 4 treated treat VBN cord-005453-4057qib7 5824 5 with with IN cord-005453-4057qib7 5824 6 ECP ECP NNP cord-005453-4057qib7 5824 7 and and CC cord-005453-4057qib7 5824 8 faster fast JJR cord-005453-4057qib7 5824 9 steroid steroid NN cord-005453-4057qib7 5824 10 tapering tapering NN cord-005453-4057qib7 5824 11 had have VBD cord-005453-4057qib7 5824 12 longer long JJR cord-005453-4057qib7 5824 13 OS os NN cord-005453-4057qib7 5824 14 compared compare VBN cord-005453-4057qib7 5824 15 to to IN cord-005453-4057qib7 5824 16 patients patient NNS cord-005453-4057qib7 5824 17 without without IN cord-005453-4057qib7 5824 18 ECP ECP NNP cord-005453-4057qib7 5824 19 ( ( -LRB- cord-005453-4057qib7 5824 20 p=0,03 p=0,03 NN cord-005453-4057qib7 5824 21 ) ) -RRB- cord-005453-4057qib7 5824 22 . . . cord-005453-4057qib7 5825 1 Conclusions conclusion NNS cord-005453-4057qib7 5825 2 : : : cord-005453-4057qib7 5826 1 ECP ECP NNP cord-005453-4057qib7 5826 2 enables enable VBZ cord-005453-4057qib7 5826 3 successful successful JJ cord-005453-4057qib7 5826 4 tapering tapering NN cord-005453-4057qib7 5826 5 or or CC cord-005453-4057qib7 5826 6 withdrawal withdrawal NN cord-005453-4057qib7 5826 7 of of IN cord-005453-4057qib7 5826 8 steroid steroid NN cord-005453-4057qib7 5826 9 therapy therapy NN cord-005453-4057qib7 5826 10 in in IN cord-005453-4057qib7 5826 11 many many JJ cord-005453-4057qib7 5826 12 patients patient NNS cord-005453-4057qib7 5826 13 , , , cord-005453-4057qib7 5826 14 even even RB cord-005453-4057qib7 5826 15 in in IN cord-005453-4057qib7 5826 16 those those DT cord-005453-4057qib7 5826 17 who who WP cord-005453-4057qib7 5826 18 are be VBP cord-005453-4057qib7 5826 19 steroid steroid NN cord-005453-4057qib7 5826 20 refractory refractory JJ cord-005453-4057qib7 5826 21 or or CC cord-005453-4057qib7 5826 22 steroid steroid NN cord-005453-4057qib7 5826 23 dependent dependent JJ cord-005453-4057qib7 5826 24 . . . cord-005453-4057qib7 5827 1 Reduction reduction NN cord-005453-4057qib7 5827 2 of of IN cord-005453-4057qib7 5827 3 immunosuppression immunosuppression NN cord-005453-4057qib7 5827 4 leads lead VBZ cord-005453-4057qib7 5827 5 to to IN cord-005453-4057qib7 5827 6 reduced reduce VBN cord-005453-4057qib7 5827 7 incidence incidence NN cord-005453-4057qib7 5827 8 of of IN cord-005453-4057qib7 5827 9 infection infection NN cord-005453-4057qib7 5827 10 and and CC cord-005453-4057qib7 5827 11 relapse relapse NN cord-005453-4057qib7 5827 12 which which WDT cord-005453-4057qib7 5827 13 translates translate VBZ cord-005453-4057qib7 5827 14 into into IN cord-005453-4057qib7 5827 15 a a DT cord-005453-4057qib7 5827 16 better well JJR cord-005453-4057qib7 5827 17 overall overall JJ cord-005453-4057qib7 5827 18 survival survival NN cord-005453-4057qib7 5827 19 . . . cord-005453-4057qib7 5828 1 Background background NN cord-005453-4057qib7 5828 2 : : : cord-005453-4057qib7 5829 1 The the DT cord-005453-4057qib7 5829 2 curative curative JJ cord-005453-4057qib7 5829 3 potential potential NN cord-005453-4057qib7 5829 4 of of IN cord-005453-4057qib7 5829 5 allogenic allogenic JJ cord-005453-4057qib7 5829 6 stem stem NN cord-005453-4057qib7 5829 7 cell cell NN cord-005453-4057qib7 5829 8 transplantation transplantation NN cord-005453-4057qib7 5829 9 is be VBZ cord-005453-4057qib7 5829 10 hampered hamper VBN cord-005453-4057qib7 5829 11 by by IN cord-005453-4057qib7 5829 12 Graft graft NN cord-005453-4057qib7 5829 13 - - HYPH cord-005453-4057qib7 5829 14 Versus Versus NNP cord-005453-4057qib7 5829 15 - - HYPH cord-005453-4057qib7 5829 16 Host host NN cord-005453-4057qib7 5829 17 disease disease NN cord-005453-4057qib7 5829 18 ( ( -LRB- cord-005453-4057qib7 5829 19 GVHD GVHD NNP cord-005453-4057qib7 5829 20 ) ) -RRB- cord-005453-4057qib7 5829 21 . . . cord-005453-4057qib7 5830 1 Pre pre JJ cord-005453-4057qib7 5830 2 - - JJ cord-005453-4057qib7 5830 3 clinical clinical JJ cord-005453-4057qib7 5830 4 study study NN cord-005453-4057qib7 5830 5 showed show VBD cord-005453-4057qib7 5830 6 an an DT cord-005453-4057qib7 5830 7 efficacity efficacity NN cord-005453-4057qib7 5830 8 of of IN cord-005453-4057qib7 5830 9 JAK1/2 JAK1/2 NNP cord-005453-4057qib7 5831 1 inhibitor inhibitor NN cord-005453-4057qib7 5831 2 , , , cord-005453-4057qib7 5831 3 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5831 4 , , , cord-005453-4057qib7 5831 5 in in IN cord-005453-4057qib7 5831 6 treatment treatment NN cord-005453-4057qib7 5831 7 of of IN cord-005453-4057qib7 5831 8 steroidrefractory steroidrefractory NNP cord-005453-4057qib7 5831 9 GVHD GVHD NNP cord-005453-4057qib7 5831 10 . . . cord-005453-4057qib7 5832 1 Methods method NNS cord-005453-4057qib7 5832 2 : : : cord-005453-4057qib7 5833 1 We -PRON- PRP cord-005453-4057qib7 5833 2 reported report VBD cord-005453-4057qib7 5833 3 in in IN cord-005453-4057qib7 5833 4 this this DT cord-005453-4057qib7 5833 5 monocentric monocentric JJ cord-005453-4057qib7 5833 6 retrospective retrospective JJ cord-005453-4057qib7 5833 7 study study NN cord-005453-4057qib7 5833 8 , , , cord-005453-4057qib7 5833 9 ruxolitinib ruxolitinib JJ cord-005453-4057qib7 5833 10 response response NN cord-005453-4057qib7 5833 11 and and CC cord-005453-4057qib7 5833 12 follow follow VB cord-005453-4057qib7 5833 13 up up IN cord-005453-4057qib7 5833 14 of of IN cord-005453-4057qib7 5833 15 44 44 CD cord-005453-4057qib7 5833 16 cases case NNS cord-005453-4057qib7 5833 17 of of IN cord-005453-4057qib7 5833 18 chronic chronic JJ cord-005453-4057qib7 5833 19 GVHD GVHD NNP cord-005453-4057qib7 5833 20 ( ( -LRB- cord-005453-4057qib7 5833 21 cGVHD cGVHD NNP cord-005453-4057qib7 5833 22 ) ) -RRB- cord-005453-4057qib7 5833 23 not not RB cord-005453-4057qib7 5833 24 improved improve VBN cord-005453-4057qib7 5833 25 with with IN cord-005453-4057qib7 5833 26 standard standard JJ cord-005453-4057qib7 5833 27 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 5833 28 therapy therapy NN cord-005453-4057qib7 5833 29 . . . cord-005453-4057qib7 5834 1 Complete complete JJ cord-005453-4057qib7 5834 2 organ organ NN cord-005453-4057qib7 5834 3 response response NN cord-005453-4057qib7 5834 4 ( ( -LRB- cord-005453-4057qib7 5834 5 CR CR NNP cord-005453-4057qib7 5834 6 ) ) -RRB- cord-005453-4057qib7 5834 7 was be VBD cord-005453-4057qib7 5834 8 defined define VBN cord-005453-4057qib7 5834 9 as as IN cord-005453-4057qib7 5834 10 the the DT cord-005453-4057qib7 5834 11 resolution resolution NN cord-005453-4057qib7 5834 12 of of IN cord-005453-4057qib7 5834 13 clinical clinical JJ cord-005453-4057qib7 5834 14 manifestations manifestation NNS cord-005453-4057qib7 5834 15 of of IN cord-005453-4057qib7 5834 16 cGVHD cGVHD NNP cord-005453-4057qib7 5834 17 in in IN cord-005453-4057qib7 5834 18 a a DT cord-005453-4057qib7 5834 19 specific specific JJ cord-005453-4057qib7 5834 20 organ organ NN cord-005453-4057qib7 5834 21 . . . cord-005453-4057qib7 5835 1 Very very RB cord-005453-4057qib7 5835 2 good good JJ cord-005453-4057qib7 5835 3 response response NN cord-005453-4057qib7 5835 4 partial partial JJ cord-005453-4057qib7 5835 5 ( ( -LRB- cord-005453-4057qib7 5835 6 VGPR VGPR NNP cord-005453-4057qib7 5835 7 ) ) -RRB- cord-005453-4057qib7 5835 8 was be VBD cord-005453-4057qib7 5835 9 defined define VBN cord-005453-4057qib7 5835 10 as as IN cord-005453-4057qib7 5835 11 an an DT cord-005453-4057qib7 5835 12 improvement improvement NN cord-005453-4057qib7 5835 13 of of IN cord-005453-4057qib7 5835 14 clinical clinical JJ cord-005453-4057qib7 5835 15 manifestations manifestation NNS cord-005453-4057qib7 5835 16 of of IN cord-005453-4057qib7 5835 17 cGVHD cGVHD NNP cord-005453-4057qib7 5835 18 with with IN cord-005453-4057qib7 5835 19 more more JJR cord-005453-4057qib7 5835 20 than than IN cord-005453-4057qib7 5835 21 50 50 CD cord-005453-4057qib7 5835 22 % % NN cord-005453-4057qib7 5835 23 decrease decrease NN cord-005453-4057qib7 5835 24 of of IN cord-005453-4057qib7 5835 25 corticosteroid corticosteroid NN cord-005453-4057qib7 5835 26 , , , cord-005453-4057qib7 5835 27 while while IN cord-005453-4057qib7 5835 28 a a DT cord-005453-4057qib7 5835 29 partial partial JJ cord-005453-4057qib7 5835 30 response response NN cord-005453-4057qib7 5835 31 ( ( -LRB- cord-005453-4057qib7 5835 32 PR PR NNP cord-005453-4057qib7 5835 33 ) ) -RRB- cord-005453-4057qib7 5835 34 was be VBD cord-005453-4057qib7 5835 35 associated associate VBN cord-005453-4057qib7 5835 36 with with IN cord-005453-4057qib7 5835 37 less less JJR cord-005453-4057qib7 5835 38 than than IN cord-005453-4057qib7 5835 39 50 50 CD cord-005453-4057qib7 5835 40 % % NN cord-005453-4057qib7 5835 41 decrease decrease NN cord-005453-4057qib7 5835 42 of of IN cord-005453-4057qib7 5835 43 corticosteroid corticosteroid NN cord-005453-4057qib7 5835 44 . . . cord-005453-4057qib7 5836 1 Treatment treatment NN cord-005453-4057qib7 5836 2 failure failure NN cord-005453-4057qib7 5836 3 was be VBD cord-005453-4057qib7 5836 4 defined define VBN cord-005453-4057qib7 5836 5 by by IN cord-005453-4057qib7 5836 6 the the DT cord-005453-4057qib7 5836 7 absence absence NN cord-005453-4057qib7 5836 8 of of IN cord-005453-4057qib7 5836 9 improvement improvement NN cord-005453-4057qib7 5836 10 of of IN cord-005453-4057qib7 5836 11 cGVHD cgvhd NN cord-005453-4057qib7 5836 12 , , , cord-005453-4057qib7 5836 13 deterioration deterioration NN cord-005453-4057qib7 5836 14 of of IN cord-005453-4057qib7 5836 15 cGVHD cgvhd NN cord-005453-4057qib7 5836 16 in in IN cord-005453-4057qib7 5836 17 any any DT cord-005453-4057qib7 5836 18 organ organ NN cord-005453-4057qib7 5836 19 by by IN cord-005453-4057qib7 5836 20 at at RB cord-005453-4057qib7 5836 21 least least RBS cord-005453-4057qib7 5836 22 one one CD cord-005453-4057qib7 5836 23 stage stage NN cord-005453-4057qib7 5836 24 , , , cord-005453-4057qib7 5836 25 the the DT cord-005453-4057qib7 5836 26 development development NN cord-005453-4057qib7 5836 27 of of IN cord-005453-4057qib7 5836 28 cGVHD cGVHD NNP cord-005453-4057qib7 5836 29 manifestations manifestation NNS cord-005453-4057qib7 5836 30 in in IN cord-005453-4057qib7 5836 31 a a DT cord-005453-4057qib7 5836 32 previously previously RB cord-005453-4057qib7 5836 33 unaffected unaffected JJ cord-005453-4057qib7 5836 34 organ organ NN cord-005453-4057qib7 5836 35 , , , cord-005453-4057qib7 5836 36 and and CC cord-005453-4057qib7 5836 37 the the DT cord-005453-4057qib7 5836 38 use use NN cord-005453-4057qib7 5836 39 of of IN cord-005453-4057qib7 5836 40 any any DT cord-005453-4057qib7 5836 41 additional additional JJ cord-005453-4057qib7 5836 42 agents agent NNS cord-005453-4057qib7 5836 43 to to TO cord-005453-4057qib7 5836 44 control control VB cord-005453-4057qib7 5836 45 the the DT cord-005453-4057qib7 5836 46 disease disease NN cord-005453-4057qib7 5836 47 . . . cord-005453-4057qib7 5837 1 Results result NNS cord-005453-4057qib7 5837 2 : : : cord-005453-4057qib7 5838 1 Median median JJ cord-005453-4057qib7 5838 2 age age NN cord-005453-4057qib7 5838 3 at at IN cord-005453-4057qib7 5838 4 transplant transplant NN cord-005453-4057qib7 5838 5 was be VBD cord-005453-4057qib7 5838 6 52 52 CD cord-005453-4057qib7 5838 7 years year NNS cord-005453-4057qib7 5839 1 ( ( -LRB- cord-005453-4057qib7 5839 2 range range NN cord-005453-4057qib7 5839 3 , , , cord-005453-4057qib7 5839 4 19 19 CD cord-005453-4057qib7 5839 5 - - SYM cord-005453-4057qib7 5839 6 66 66 CD cord-005453-4057qib7 5839 7 ) ) -RRB- cord-005453-4057qib7 5839 8 . . . cord-005453-4057qib7 5840 1 59 59 CD cord-005453-4057qib7 5840 2 % % NN cord-005453-4057qib7 5840 3 of of IN cord-005453-4057qib7 5840 4 patients patient NNS cord-005453-4057qib7 5840 5 presented present VBD cord-005453-4057qib7 5840 6 an an DT cord-005453-4057qib7 5840 7 acute acute JJ cord-005453-4057qib7 5840 8 myeloid myeloid NN cord-005453-4057qib7 5840 9 leukemia leukemia NN cord-005453-4057qib7 5840 10 . . . cord-005453-4057qib7 5841 1 Donor donor NN cord-005453-4057qib7 5841 2 type type NN cord-005453-4057qib7 5841 3 was be VBD cord-005453-4057qib7 5841 4 sibling sible VBG cord-005453-4057qib7 5841 5 ( ( -LRB- cord-005453-4057qib7 5841 6 n=12 n=12 NNP cord-005453-4057qib7 5841 7 ) ) -RRB- cord-005453-4057qib7 5841 8 , , , cord-005453-4057qib7 5841 9 unrelated unrelated JJ cord-005453-4057qib7 5841 10 ( ( -LRB- cord-005453-4057qib7 5841 11 n=24 n=24 NNP cord-005453-4057qib7 5841 12 ) ) -RRB- cord-005453-4057qib7 5841 13 or or CC cord-005453-4057qib7 5841 14 haploidentical haploidentical JJ cord-005453-4057qib7 5841 15 ( ( -LRB- cord-005453-4057qib7 5841 16 n=6).Two n=6).Two NNP cord-005453-4057qib7 5841 17 patients patient NNS cord-005453-4057qib7 5841 18 benefited benefit VBD cord-005453-4057qib7 5841 19 a a DT cord-005453-4057qib7 5841 20 cord cord NN cord-005453-4057qib7 5841 21 blood blood NN cord-005453-4057qib7 5841 22 transplant transplant NN cord-005453-4057qib7 5841 23 . . . cord-005453-4057qib7 5842 1 Patients patient NNS cord-005453-4057qib7 5842 2 received receive VBD cord-005453-4057qib7 5842 3 either either CC cord-005453-4057qib7 5842 4 myeloablative myeloablative NNP cord-005453-4057qib7 5842 5 ( ( -LRB- cord-005453-4057qib7 5842 6 64 64 CD cord-005453-4057qib7 5842 7 % % NN cord-005453-4057qib7 5842 8 ) ) -RRB- cord-005453-4057qib7 5842 9 or or CC cord-005453-4057qib7 5842 10 reduced reduce VBN cord-005453-4057qib7 5842 11 intensity intensity NN cord-005453-4057qib7 5842 12 ( ( -LRB- cord-005453-4057qib7 5842 13 36 36 CD cord-005453-4057qib7 5842 14 % % NN cord-005453-4057qib7 5842 15 ) ) -RRB- cord-005453-4057qib7 5842 16 conditioning conditioning NN cord-005453-4057qib7 5842 17 regimens regimen NNS cord-005453-4057qib7 5842 18 . . . cord-005453-4057qib7 5843 1 Stem stem JJ cord-005453-4057qib7 5843 2 cell cell NN cord-005453-4057qib7 5843 3 source source NN cord-005453-4057qib7 5843 4 was be VBD cord-005453-4057qib7 5843 5 peripheral peripheral JJ cord-005453-4057qib7 5843 6 blood blood NN cord-005453-4057qib7 5843 7 for for IN cord-005453-4057qib7 5843 8 75 75 CD cord-005453-4057qib7 5843 9 % % NN cord-005453-4057qib7 5843 10 of of IN cord-005453-4057qib7 5843 11 patients patient NNS cord-005453-4057qib7 5843 12 . . . cord-005453-4057qib7 5844 1 Patients patient NNS cord-005453-4057qib7 5844 2 presented present VBD cord-005453-4057qib7 5844 3 mild mild JJ cord-005453-4057qib7 5844 4 ( ( -LRB- cord-005453-4057qib7 5844 5 n=11 n=11 FW cord-005453-4057qib7 5844 6 ) ) -RRB- cord-005453-4057qib7 5844 7 , , , cord-005453-4057qib7 5844 8 moderate moderate JJ cord-005453-4057qib7 5844 9 ( ( -LRB- cord-005453-4057qib7 5844 10 n=21 n=21 JJ cord-005453-4057qib7 5844 11 ) ) -RRB- cord-005453-4057qib7 5844 12 or or CC cord-005453-4057qib7 5844 13 severe severe JJ cord-005453-4057qib7 5844 14 ( ( -LRB- cord-005453-4057qib7 5844 15 n=12 n=12 NNP cord-005453-4057qib7 5844 16 ) ) -RRB- cord-005453-4057qib7 5844 17 cGVHD cGVHD NNP cord-005453-4057qib7 5845 1 according accord VBG cord-005453-4057qib7 5845 2 to to IN cord-005453-4057qib7 5845 3 NIH NIH NNP cord-005453-4057qib7 5845 4 score score NN cord-005453-4057qib7 5845 5 . . . cord-005453-4057qib7 5846 1 Median median JJ cord-005453-4057qib7 5846 2 number number NN cord-005453-4057qib7 5846 3 of of IN cord-005453-4057qib7 5846 4 regimens regimen NNS cord-005453-4057qib7 5846 5 prior prior RB cord-005453-4057qib7 5846 6 to to IN cord-005453-4057qib7 5846 7 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5846 8 was be VBD cord-005453-4057qib7 5846 9 1 1 CD cord-005453-4057qib7 5847 1 ( ( -LRB- cord-005453-4057qib7 5847 2 range range NN cord-005453-4057qib7 5847 3 , , , cord-005453-4057qib7 5847 4 0 0 CD cord-005453-4057qib7 5847 5 - - SYM cord-005453-4057qib7 5847 6 6 6 CD cord-005453-4057qib7 5847 7 ) ) -RRB- cord-005453-4057qib7 5847 8 , , , cord-005453-4057qib7 5847 9 among among IN cord-005453-4057qib7 5847 10 those those DT cord-005453-4057qib7 5847 11 corticosteroids corticosteroid NNS cord-005453-4057qib7 5847 12 ( ( -LRB- cord-005453-4057qib7 5847 13 n=36 n=36 NNS cord-005453-4057qib7 5847 14 ) ) -RRB- cord-005453-4057qib7 5847 15 . . . cord-005453-4057qib7 5848 1 Median median JJ cord-005453-4057qib7 5848 2 follow follow NN cord-005453-4057qib7 5848 3 - - HYPH cord-005453-4057qib7 5848 4 up up NN cord-005453-4057qib7 5848 5 after after IN cord-005453-4057qib7 5848 6 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5848 7 was be VBD cord-005453-4057qib7 5848 8 18 18 CD cord-005453-4057qib7 5848 9 months month NNS cord-005453-4057qib7 5848 10 ( ( -LRB- cord-005453-4057qib7 5848 11 range range NN cord-005453-4057qib7 5848 12 , , , cord-005453-4057qib7 5848 13 4 4 CD cord-005453-4057qib7 5848 14 - - SYM cord-005453-4057qib7 5848 15 32 32 CD cord-005453-4057qib7 5848 16 ) ) -RRB- cord-005453-4057qib7 5848 17 . . . cord-005453-4057qib7 5849 1 Overall overall JJ cord-005453-4057qib7 5849 2 responses response NNS cord-005453-4057qib7 5849 3 rate rate NN cord-005453-4057qib7 5849 4 ( ( -LRB- cord-005453-4057qib7 5849 5 ORR ORR NNP cord-005453-4057qib7 5849 6 ) ) -RRB- cord-005453-4057qib7 5849 7 at at IN cord-005453-4057qib7 5849 8 1 1 CD cord-005453-4057qib7 5849 9 month month NN cord-005453-4057qib7 5849 10 was be VBD cord-005453-4057qib7 5849 11 84 84 CD cord-005453-4057qib7 5849 12 % % NN cord-005453-4057qib7 5849 13 with with IN cord-005453-4057qib7 5849 14 34 34 CD cord-005453-4057qib7 5849 15 % % NN cord-005453-4057qib7 5849 16 CR cr NN cord-005453-4057qib7 5849 17 , , , cord-005453-4057qib7 5849 18 6 6 CD cord-005453-4057qib7 5849 19 % % NN cord-005453-4057qib7 5849 20 VGPR vgpr NN cord-005453-4057qib7 5849 21 and and CC cord-005453-4057qib7 5849 22 43 43 CD cord-005453-4057qib7 5849 23 % % NN cord-005453-4057qib7 5849 24 PR pr NN cord-005453-4057qib7 5849 25 ( ( -LRB- cord-005453-4057qib7 5849 26 Figure figure NN cord-005453-4057qib7 5849 27 1 1 CD cord-005453-4057qib7 5849 28 ) ) -RRB- cord-005453-4057qib7 5849 29 . . . cord-005453-4057qib7 5850 1 13 13 CD cord-005453-4057qib7 5850 2 % % NN cord-005453-4057qib7 5850 3 of of IN cord-005453-4057qib7 5850 4 patients patient NNS cord-005453-4057qib7 5850 5 failed fail VBD cord-005453-4057qib7 5850 6 at at IN cord-005453-4057qib7 5850 7 1 1 CD cord-005453-4057qib7 5850 8 month month NN cord-005453-4057qib7 5850 9 after after IN cord-005453-4057qib7 5850 10 introduction introduction NN cord-005453-4057qib7 5850 11 of of IN cord-005453-4057qib7 5850 12 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5850 13 . . . cord-005453-4057qib7 5851 1 The the DT cord-005453-4057qib7 5851 2 rate rate NN cord-005453-4057qib7 5851 3 of of IN cord-005453-4057qib7 5851 4 CR cr NN cord-005453-4057qib7 5851 5 increased increase VBD cord-005453-4057qib7 5851 6 with with IN cord-005453-4057qib7 5851 7 time time NN cord-005453-4057qib7 5851 8 : : : cord-005453-4057qib7 5851 9 45 45 CD cord-005453-4057qib7 5851 10 % % NN cord-005453-4057qib7 5851 11 at at IN cord-005453-4057qib7 5851 12 3 3 CD cord-005453-4057qib7 5851 13 months month NNS cord-005453-4057qib7 5851 14 ( ( -LRB- cord-005453-4057qib7 5851 15 n=38 n=38 NNP cord-005453-4057qib7 5851 16 ) ) -RRB- cord-005453-4057qib7 5851 17 , , , cord-005453-4057qib7 5851 18 53 53 CD cord-005453-4057qib7 5851 19 % % NN cord-005453-4057qib7 5851 20 at at IN cord-005453-4057qib7 5851 21 6 6 CD cord-005453-4057qib7 5851 22 months month NNS cord-005453-4057qib7 5851 23 ( ( -LRB- cord-005453-4057qib7 5851 24 n=30 n=30 NNP cord-005453-4057qib7 5851 25 ) ) -RRB- cord-005453-4057qib7 5851 26 and and CC cord-005453-4057qib7 5851 27 65 65 CD cord-005453-4057qib7 5851 28 % % NN cord-005453-4057qib7 5851 29 at at IN cord-005453-4057qib7 5851 30 12 12 CD cord-005453-4057qib7 5851 31 months month NNS cord-005453-4057qib7 5851 32 ( ( -LRB- cord-005453-4057qib7 5851 33 n=23 n=23 NN cord-005453-4057qib7 5851 34 ) ) -RRB- cord-005453-4057qib7 5851 35 . . . cord-005453-4057qib7 5852 1 But but CC cord-005453-4057qib7 5852 2 VGPR VGPR NNP cord-005453-4057qib7 5852 3 rate rate NN cord-005453-4057qib7 5852 4 was be VBD cord-005453-4057qib7 5852 5 rather rather RB cord-005453-4057qib7 5852 6 stable stable JJ cord-005453-4057qib7 5852 7 at at IN cord-005453-4057qib7 5852 8 3 3 CD cord-005453-4057qib7 5852 9 months month NNS cord-005453-4057qib7 5852 10 ( ( -LRB- cord-005453-4057qib7 5852 11 24 24 CD cord-005453-4057qib7 5852 12 % % NN cord-005453-4057qib7 5852 13 ) ) -RRB- cord-005453-4057qib7 5852 14 , , , cord-005453-4057qib7 5852 15 at at IN cord-005453-4057qib7 5852 16 6 6 CD cord-005453-4057qib7 5852 17 months month NNS cord-005453-4057qib7 5852 18 ( ( -LRB- cord-005453-4057qib7 5852 19 33 33 CD cord-005453-4057qib7 5852 20 % % NN cord-005453-4057qib7 5852 21 ) ) -RRB- cord-005453-4057qib7 5852 22 and and CC cord-005453-4057qib7 5852 23 at at IN cord-005453-4057qib7 5852 24 12 12 CD cord-005453-4057qib7 5852 25 months month NNS cord-005453-4057qib7 5852 26 ( ( -LRB- cord-005453-4057qib7 5852 27 22 22 CD cord-005453-4057qib7 5852 28 % % NN cord-005453-4057qib7 5852 29 ) ) -RRB- cord-005453-4057qib7 5852 30 vs vs IN cord-005453-4057qib7 5852 31 6 6 CD cord-005453-4057qib7 5852 32 % % NN cord-005453-4057qib7 5852 33 at at IN cord-005453-4057qib7 5852 34 1 1 CD cord-005453-4057qib7 5852 35 month month NN cord-005453-4057qib7 5852 36 . . . cord-005453-4057qib7 5853 1 Among among IN cord-005453-4057qib7 5853 2 the the DT cord-005453-4057qib7 5853 3 patients patient NNS cord-005453-4057qib7 5853 4 under under IN cord-005453-4057qib7 5853 5 steroids steroid NNS cord-005453-4057qib7 5853 6 , , , cord-005453-4057qib7 5853 7 21 21 CD cord-005453-4057qib7 5853 8 ( ( -LRB- cord-005453-4057qib7 5853 9 58 58 CD cord-005453-4057qib7 5853 10 % % NN cord-005453-4057qib7 5853 11 ) ) -RRB- cord-005453-4057qib7 5853 12 patients patient NNS cord-005453-4057qib7 5853 13 discontinued discontinue VBD cord-005453-4057qib7 5853 14 steroids steroid NNS cord-005453-4057qib7 5853 15 . . . cord-005453-4057qib7 5854 1 The the DT cord-005453-4057qib7 5854 2 12-months 12-months CD cord-005453-4057qib7 5854 3 overall overall JJ cord-005453-4057qib7 5854 4 survival survival NN cord-005453-4057qib7 5854 5 ( ( -LRB- cord-005453-4057qib7 5854 6 OS OS NNP cord-005453-4057qib7 5854 7 ) ) -RRB- cord-005453-4057qib7 5854 8 and and CC cord-005453-4057qib7 5854 9 diseasefree diseasefree NNP cord-005453-4057qib7 5854 10 survival survival NNP cord-005453-4057qib7 5854 11 ( ( -LRB- cord-005453-4057qib7 5854 12 DFS DFS NNP cord-005453-4057qib7 5854 13 ) ) -RRB- cord-005453-4057qib7 5855 1 after after IN cord-005453-4057qib7 5855 2 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5855 3 was be VBD cord-005453-4057qib7 5855 4 89 89 CD cord-005453-4057qib7 5855 5 % % NN cord-005453-4057qib7 5855 6 ( ( -LRB- cord-005453-4057qib7 5855 7 80%-99 80%-99 CD cord-005453-4057qib7 5855 8 % % NN cord-005453-4057qib7 5855 9 , , , cord-005453-4057qib7 5855 10 95 95 CD cord-005453-4057qib7 5855 11 % % NN cord-005453-4057qib7 5855 12 CI CI NNP cord-005453-4057qib7 5855 13 ) ) -RRB- cord-005453-4057qib7 5855 14 and and CC cord-005453-4057qib7 5855 15 86 86 CD cord-005453-4057qib7 5855 16 % % NN cord-005453-4057qib7 5855 17 ( ( -LRB- cord-005453-4057qib7 5855 18 76%-96 76%-96 CD cord-005453-4057qib7 5855 19 % % NN cord-005453-4057qib7 5855 20 , , , cord-005453-4057qib7 5855 21 95 95 CD cord-005453-4057qib7 5855 22 % % NN cord-005453-4057qib7 5855 23 CI CI NNP cord-005453-4057qib7 5855 24 ) ) -RRB- cord-005453-4057qib7 5855 25 , , , cord-005453-4057qib7 5855 26 respectively respectively RB cord-005453-4057qib7 5855 27 . . . cord-005453-4057qib7 5856 1 Severe severe JJ cord-005453-4057qib7 5856 2 cytopenia cytopenia NNS cord-005453-4057qib7 5856 3 ( ( -LRB- cord-005453-4057qib7 5856 4 grade grade NN cord-005453-4057qib7 5856 5 3 3 CD cord-005453-4057qib7 5856 6 and and CC cord-005453-4057qib7 5856 7 4 4 CD cord-005453-4057qib7 5856 8 ) ) -RRB- cord-005453-4057qib7 5856 9 was be VBD cord-005453-4057qib7 5856 10 observed observe VBN cord-005453-4057qib7 5856 11 in in IN cord-005453-4057qib7 5856 12 12 12 CD cord-005453-4057qib7 5856 13 patients patient NNS cord-005453-4057qib7 5856 14 . . . cord-005453-4057qib7 5857 1 After after IN cord-005453-4057qib7 5857 2 introduction introduction NN cord-005453-4057qib7 5857 3 of of IN cord-005453-4057qib7 5857 4 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5857 5 , , , cord-005453-4057qib7 5857 6 4 4 CD cord-005453-4057qib7 5857 7 patients patient NNS cord-005453-4057qib7 5857 8 presented present VBD cord-005453-4057qib7 5857 9 bacterial bacterial JJ cord-005453-4057qib7 5857 10 infections infection NNS cord-005453-4057qib7 5857 11 , , , cord-005453-4057qib7 5857 12 3 3 CD cord-005453-4057qib7 5857 13 patients patient NNS cord-005453-4057qib7 5857 14 presented present VBD cord-005453-4057qib7 5857 15 an an DT cord-005453-4057qib7 5857 16 invasive invasive JJ cord-005453-4057qib7 5857 17 pulmonary pulmonary JJ cord-005453-4057qib7 5857 18 aspergillosis aspergillosis NN cord-005453-4057qib7 5857 19 and and CC cord-005453-4057qib7 5857 20 1 1 CD cord-005453-4057qib7 5857 21 patient patient NN cord-005453-4057qib7 5857 22 developped developpe VBD cord-005453-4057qib7 5857 23 a a DT cord-005453-4057qib7 5857 24 pneumocystis pneumocystis NN cord-005453-4057qib7 5857 25 . . . cord-005453-4057qib7 5858 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 5858 2 reactivation reactivation NN cord-005453-4057qib7 5858 3 requiring require VBG cord-005453-4057qib7 5858 4 preemptive preemptive JJ cord-005453-4057qib7 5858 5 treatment treatment NN cord-005453-4057qib7 5858 6 was be VBD cord-005453-4057qib7 5858 7 observed observe VBN cord-005453-4057qib7 5858 8 in in IN cord-005453-4057qib7 5858 9 7 7 CD cord-005453-4057qib7 5858 10 patients patient NNS cord-005453-4057qib7 5858 11 . . . cord-005453-4057qib7 5859 1 No no DT cord-005453-4057qib7 5859 2 toxicities toxicity NNS cord-005453-4057qib7 5859 3 required require VBD cord-005453-4057qib7 5859 4 withdrawal withdrawal NN cord-005453-4057qib7 5859 5 of of IN cord-005453-4057qib7 5859 6 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 5859 7 . . . cord-005453-4057qib7 5860 1 [ [ -LRB- cord-005453-4057qib7 5860 2 [ [ -LRB- cord-005453-4057qib7 5860 3 P269 P269 `` cord-005453-4057qib7 5860 4 Image image NN cord-005453-4057qib7 5860 5 ] ] -RRB- cord-005453-4057qib7 5860 6 1 1 CD cord-005453-4057qib7 5860 7 . . . cord-005453-4057qib7 5861 1 Figure figure NN cord-005453-4057qib7 5861 2 1 1 CD cord-005453-4057qib7 5861 3 and and CC cord-005453-4057qib7 5861 4 partial partial JJ cord-005453-4057qib7 5861 5 response response NN cord-005453-4057qib7 5861 6 to to IN cord-005453-4057qib7 5861 7 mesenchymal mesenchymal JJ cord-005453-4057qib7 5861 8 stem stem NN cord-005453-4057qib7 5861 9 cells cell NNS cord-005453-4057qib7 5861 10 ( ( -LRB- cord-005453-4057qib7 5861 11 MSC MSC NNP cord-005453-4057qib7 5861 12 ) ) -RRB- cord-005453-4057qib7 5861 13 , , , cord-005453-4057qib7 5861 14 as as IN cord-005453-4057qib7 5861 15 second second JJ cord-005453-4057qib7 5861 16 - - HYPH cord-005453-4057qib7 5861 17 line line NN cord-005453-4057qib7 5861 18 therapy therapy NN cord-005453-4057qib7 5861 19 , , , cord-005453-4057qib7 5861 20 varies vary VBZ cord-005453-4057qib7 5861 21 from from IN cord-005453-4057qib7 5861 22 15 15 CD cord-005453-4057qib7 5861 23 % % NN cord-005453-4057qib7 5861 24 to to IN cord-005453-4057qib7 5861 25 82 82 CD cord-005453-4057qib7 5861 26 % % NN cord-005453-4057qib7 5861 27 in in IN cord-005453-4057qib7 5861 28 acute acute JJ cord-005453-4057qib7 5861 29 GVHD GVHD NNP cord-005453-4057qib7 5861 30 patients patient NNS cord-005453-4057qib7 5861 31 . . . cord-005453-4057qib7 5862 1 We -PRON- PRP cord-005453-4057qib7 5862 2 report report VBP cord-005453-4057qib7 5862 3 our -PRON- PRP$ cord-005453-4057qib7 5862 4 experience experience NN cord-005453-4057qib7 5862 5 using use VBG cord-005453-4057qib7 5862 6 MSCs msc NNS cord-005453-4057qib7 5862 7 to to TO cord-005453-4057qib7 5862 8 treat treat VB cord-005453-4057qib7 5862 9 refractory refractory JJ cord-005453-4057qib7 5862 10 aGVHD agvhd NN cord-005453-4057qib7 5862 11 . . . cord-005453-4057qib7 5863 1 Methods method NNS cord-005453-4057qib7 5863 2 : : : cord-005453-4057qib7 5864 1 The the DT cord-005453-4057qib7 5864 2 study study NN cord-005453-4057qib7 5864 3 was be VBD cord-005453-4057qib7 5864 4 a a DT cord-005453-4057qib7 5864 5 retrospective retrospective JJ cord-005453-4057qib7 5864 6 single single JJ cord-005453-4057qib7 5864 7 center center NN cord-005453-4057qib7 5864 8 study study NN cord-005453-4057qib7 5864 9 . . . cord-005453-4057qib7 5865 1 All all DT cord-005453-4057qib7 5865 2 data datum NNS cord-005453-4057qib7 5865 3 were be VBD cord-005453-4057qib7 5865 4 collected collect VBN cord-005453-4057qib7 5865 5 from from IN cord-005453-4057qib7 5865 6 patients patient NNS cord-005453-4057qib7 5865 7 ' ' POS cord-005453-4057qib7 5865 8 files file NNS cord-005453-4057qib7 5865 9 . . . cord-005453-4057qib7 5866 1 Twenty twenty CD cord-005453-4057qib7 5866 2 patients patient NNS cord-005453-4057qib7 5866 3 were be VBD cord-005453-4057qib7 5866 4 enrolled enrol VBN cord-005453-4057qib7 5866 5 ( ( -LRB- cord-005453-4057qib7 5866 6 age age NN cord-005453-4057qib7 5866 7 ranging range VBG cord-005453-4057qib7 5866 8 from from IN cord-005453-4057qib7 5866 9 7 7 CD cord-005453-4057qib7 5866 10 months month NNS cord-005453-4057qib7 5866 11 to to IN cord-005453-4057qib7 5866 12 19 19 CD cord-005453-4057qib7 5866 13 years year NNS cord-005453-4057qib7 5866 14 ) ) -RRB- cord-005453-4057qib7 5866 15 between between IN cord-005453-4057qib7 5866 16 April April NNP cord-005453-4057qib7 5866 17 2014 2014 CD cord-005453-4057qib7 5866 18 and and CC cord-005453-4057qib7 5866 19 April April NNP cord-005453-4057qib7 5866 20 2018 2018 CD cord-005453-4057qib7 5866 21 . . . cord-005453-4057qib7 5867 1 Results result NNS cord-005453-4057qib7 5867 2 : : : cord-005453-4057qib7 5868 1 Five five CD cord-005453-4057qib7 5868 2 of of IN cord-005453-4057qib7 5868 3 these these DT cord-005453-4057qib7 5868 4 patients patient NNS cord-005453-4057qib7 5868 5 received receive VBD cord-005453-4057qib7 5868 6 reduced reduced JJ cord-005453-4057qib7 5868 7 intensity intensity NN cord-005453-4057qib7 5868 8 conditioning conditioning NN cord-005453-4057qib7 5868 9 and and CC cord-005453-4057qib7 5868 10 15 15 CD cord-005453-4057qib7 5868 11 patients patient NNS cord-005453-4057qib7 5868 12 received receive VBD cord-005453-4057qib7 5868 13 myeloablative myeloablative NNP cord-005453-4057qib7 5868 14 regimens regimen NNS cord-005453-4057qib7 5868 15 before before IN cord-005453-4057qib7 5868 16 HSCT HSCT NNP cord-005453-4057qib7 5868 17 . . . cord-005453-4057qib7 5869 1 One one CD cord-005453-4057qib7 5869 2 haploidentical haploidentical JJ cord-005453-4057qib7 5869 3 , , , cord-005453-4057qib7 5869 4 1 1 CD cord-005453-4057qib7 5869 5 autologous autologous JJ cord-005453-4057qib7 5869 6 , , , cord-005453-4057qib7 5869 7 1 1 CD cord-005453-4057qib7 5869 8 cord cord NN cord-005453-4057qib7 5869 9 blood blood NN cord-005453-4057qib7 5869 10 , , , cord-005453-4057qib7 5869 11 14 14 CD cord-005453-4057qib7 5869 12 MUD mud NN cord-005453-4057qib7 5869 13 , , , cord-005453-4057qib7 5869 14 3 3 CD cord-005453-4057qib7 5869 15 MSD MSD NNP cord-005453-4057qib7 5869 16 transplantations transplantation NNS cord-005453-4057qib7 5869 17 were be VBD cord-005453-4057qib7 5869 18 performed perform VBN cord-005453-4057qib7 5869 19 . . . cord-005453-4057qib7 5870 1 The the DT cord-005453-4057qib7 5870 2 patients patient NNS cord-005453-4057qib7 5870 3 were be VBD cord-005453-4057qib7 5870 4 eligible eligible JJ cord-005453-4057qib7 5870 5 if if IN cord-005453-4057qib7 5870 6 they -PRON- PRP cord-005453-4057qib7 5870 7 developed develop VBD cord-005453-4057qib7 5870 8 grades grade NNS cord-005453-4057qib7 5870 9 II II NNP cord-005453-4057qib7 5870 10 - - HYPH cord-005453-4057qib7 5870 11 IV IV NNP cord-005453-4057qib7 5870 12 aGVHD aGVHD NNP cord-005453-4057qib7 5870 13 . . . cord-005453-4057qib7 5871 1 All all DT cord-005453-4057qib7 5871 2 patients patient NNS cord-005453-4057qib7 5871 3 were be VBD cord-005453-4057qib7 5871 4 treated treat VBN cord-005453-4057qib7 5871 5 with with IN cord-005453-4057qib7 5871 6 standard standard JJ cord-005453-4057qib7 5871 7 first first JJ cord-005453-4057qib7 5871 8 - - HYPH cord-005453-4057qib7 5871 9 line line NN cord-005453-4057qib7 5871 10 treatment treatment NN cord-005453-4057qib7 5871 11 with with IN cord-005453-4057qib7 5871 12 corticosteroids corticosteroid NNS cord-005453-4057qib7 5871 13 and and CC cord-005453-4057qib7 5871 14 at at RB cord-005453-4057qib7 5871 15 least least RBS cord-005453-4057qib7 5871 16 one one CD cord-005453-4057qib7 5871 17 second second JJ cord-005453-4057qib7 5871 18 - - HYPH cord-005453-4057qib7 5871 19 line line NN cord-005453-4057qib7 5871 20 therapy therapy NN cord-005453-4057qib7 5871 21 . . . cord-005453-4057qib7 5872 1 The the DT cord-005453-4057qib7 5872 2 definition definition NN cord-005453-4057qib7 5872 3 of of IN cord-005453-4057qib7 5872 4 steroid steroid NN cord-005453-4057qib7 5872 5 resistant resistant JJ cord-005453-4057qib7 5872 6 aGVHD aGVHD NNP cord-005453-4057qib7 5872 7 considered consider VBN cord-005453-4057qib7 5872 8 as as IN cord-005453-4057qib7 5872 9 either either CC cord-005453-4057qib7 5872 10 no no DT cord-005453-4057qib7 5872 11 response response NN cord-005453-4057qib7 5872 12 to to IN cord-005453-4057qib7 5872 13 steroid steroid NN cord-005453-4057qib7 5872 14 treatment treatment NN cord-005453-4057qib7 5872 15 lasting last VBG cord-005453-4057qib7 5872 16 at at RB cord-005453-4057qib7 5872 17 least least JJS cord-005453-4057qib7 5872 18 7 7 CD cord-005453-4057qib7 5872 19 days day NNS cord-005453-4057qib7 5872 20 or or CC cord-005453-4057qib7 5872 21 progression progression NN cord-005453-4057qib7 5872 22 during during IN cord-005453-4057qib7 5872 23 treatment treatment NN cord-005453-4057qib7 5872 24 of of IN cord-005453-4057qib7 5872 25 at at RB cord-005453-4057qib7 5872 26 least least RBS cord-005453-4057qib7 5872 27 one one CD cord-005453-4057qib7 5872 28 grade grade NN cord-005453-4057qib7 5872 29 within within IN cord-005453-4057qib7 5872 30 the the DT cord-005453-4057qib7 5872 31 first first JJ cord-005453-4057qib7 5872 32 72 72 CD cord-005453-4057qib7 5872 33 hours hour NNS cord-005453-4057qib7 5872 34 . . . cord-005453-4057qib7 5873 1 Prophylactic prophylactic JJ cord-005453-4057qib7 5873 2 treatment treatment NN cord-005453-4057qib7 5873 3 with with IN cord-005453-4057qib7 5873 4 calcineurin calcineurin NNP cord-005453-4057qib7 5873 5 inhibitors inhibitor NNS cord-005453-4057qib7 5873 6 continued continue VBD cord-005453-4057qib7 5873 7 at at IN cord-005453-4057qib7 5873 8 therapeutic therapeutic JJ cord-005453-4057qib7 5873 9 dose dose JJ cord-005453-4057qib7 5873 10 level level NN cord-005453-4057qib7 5873 11 . . . cord-005453-4057qib7 5874 1 Totally totally RB cord-005453-4057qib7 5874 2 , , , cord-005453-4057qib7 5874 3 77 77 CD cord-005453-4057qib7 5874 4 doses dose NNS cord-005453-4057qib7 5874 5 of of IN cord-005453-4057qib7 5874 6 MSCs msc NNS cord-005453-4057qib7 5874 7 were be VBD cord-005453-4057qib7 5874 8 infused infuse VBN cord-005453-4057qib7 5874 9 . . . cord-005453-4057qib7 5875 1 The the DT cord-005453-4057qib7 5875 2 median median JJ cord-005453-4057qib7 5875 3 dose dose NN cord-005453-4057qib7 5875 4 of of IN cord-005453-4057qib7 5875 5 MSC MSC NNP cord-005453-4057qib7 5875 6 was be VBD cord-005453-4057qib7 5875 7 1.02 1.02 CD cord-005453-4057qib7 5875 8 × × NN cord-005453-4057qib7 5875 9 10 10 CD cord-005453-4057qib7 5875 10 6 6 CD cord-005453-4057qib7 5875 11 cells cell NNS cord-005453-4057qib7 5875 12 per per IN cord-005453-4057qib7 5875 13 kg kg NN cord-005453-4057qib7 5875 14 body body NN cord-005453-4057qib7 5875 15 weight weight NN cord-005453-4057qib7 5875 16 . . . cord-005453-4057qib7 5876 1 The the DT cord-005453-4057qib7 5876 2 median median JJ cord-005453-4057qib7 5876 3 duration duration NN cord-005453-4057qib7 5876 4 between between IN cord-005453-4057qib7 5876 5 the the DT cord-005453-4057qib7 5876 6 diagnosis diagnosis NN cord-005453-4057qib7 5876 7 of of IN cord-005453-4057qib7 5876 8 aGVHD agvhd NN cord-005453-4057qib7 5876 9 and and CC cord-005453-4057qib7 5876 10 initiation initiation NN cord-005453-4057qib7 5876 11 of of IN cord-005453-4057qib7 5876 12 MSCs mscs NN cord-005453-4057qib7 5876 13 therapy therapy NN cord-005453-4057qib7 5876 14 was be VBD cord-005453-4057qib7 5876 15 16 16 CD cord-005453-4057qib7 5876 16 days day NNS cord-005453-4057qib7 5876 17 ( ( -LRB- cord-005453-4057qib7 5876 18 range range NN cord-005453-4057qib7 5876 19 : : : cord-005453-4057qib7 5876 20 4 4 CD cord-005453-4057qib7 5876 21 - - SYM cord-005453-4057qib7 5876 22 241 241 CD cord-005453-4057qib7 5876 23 ) ) -RRB- cord-005453-4057qib7 5876 24 . . . cord-005453-4057qib7 5877 1 The the DT cord-005453-4057qib7 5877 2 received receive VBN cord-005453-4057qib7 5877 3 MSC MSC NNP cord-005453-4057qib7 5877 4 doses dose NNS cord-005453-4057qib7 5877 5 ranged range VBD cord-005453-4057qib7 5877 6 from from IN cord-005453-4057qib7 5877 7 one one CD cord-005453-4057qib7 5877 8 to to IN cord-005453-4057qib7 5877 9 seven seven CD cord-005453-4057qib7 5877 10 . . . cord-005453-4057qib7 5878 1 None none NN cord-005453-4057qib7 5878 2 of of IN cord-005453-4057qib7 5878 3 our -PRON- PRP$ cord-005453-4057qib7 5878 4 patients patient NNS cord-005453-4057qib7 5878 5 had have VBD cord-005453-4057qib7 5878 6 severe severe JJ cord-005453-4057qib7 5878 7 side side NN cord-005453-4057qib7 5878 8 - - HYPH cord-005453-4057qib7 5878 9 effects effect NNS cord-005453-4057qib7 5878 10 during during IN cord-005453-4057qib7 5878 11 infusions infusion NNS cord-005453-4057qib7 5878 12 of of IN cord-005453-4057qib7 5878 13 MSCs msc NNS cord-005453-4057qib7 5878 14 . . . cord-005453-4057qib7 5879 1 Overall overall RB cord-005453-4057qib7 5879 2 , , , cord-005453-4057qib7 5879 3 complete complete JJ cord-005453-4057qib7 5879 4 response response NN cord-005453-4057qib7 5879 5 ( ( -LRB- cord-005453-4057qib7 5879 6 OCR OCR NNP cord-005453-4057qib7 5879 7 ) ) -RRB- cord-005453-4057qib7 5879 8 was be VBD cord-005453-4057qib7 5879 9 obtained obtain VBN cord-005453-4057qib7 5879 10 in in IN cord-005453-4057qib7 5879 11 10 10 CD cord-005453-4057qib7 5879 12 patients patient NNS cord-005453-4057qib7 5879 13 , , , cord-005453-4057qib7 5879 14 partial partial JJ cord-005453-4057qib7 5879 15 response response NN cord-005453-4057qib7 5879 16 in in IN cord-005453-4057qib7 5879 17 7 7 CD cord-005453-4057qib7 5879 18 patients patient NNS cord-005453-4057qib7 5879 19 and and CC cord-005453-4057qib7 5879 20 no no DT cord-005453-4057qib7 5879 21 response response NN cord-005453-4057qib7 5879 22 ( ( -LRB- cord-005453-4057qib7 5879 23 NR NR NNP cord-005453-4057qib7 5879 24 ) ) -RRB- cord-005453-4057qib7 5879 25 was be VBD cord-005453-4057qib7 5879 26 documented document VBN cord-005453-4057qib7 5879 27 in in IN cord-005453-4057qib7 5879 28 3 3 CD cord-005453-4057qib7 5879 29 patients patient NNS cord-005453-4057qib7 5879 30 . . . cord-005453-4057qib7 5880 1 In in IN cord-005453-4057qib7 5880 2 our -PRON- PRP$ cord-005453-4057qib7 5880 3 study study NN cord-005453-4057qib7 5880 4 group group NN cord-005453-4057qib7 5880 5 , , , cord-005453-4057qib7 5880 6 the the DT cord-005453-4057qib7 5880 7 complete complete JJ cord-005453-4057qib7 5880 8 response response NN cord-005453-4057qib7 5880 9 rates rate NNS cord-005453-4057qib7 5880 10 in in IN cord-005453-4057qib7 5880 11 liver liver NN cord-005453-4057qib7 5880 12 , , , cord-005453-4057qib7 5880 13 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 5880 14 , , , cord-005453-4057qib7 5880 15 skin skin NN cord-005453-4057qib7 5880 16 aGVHD agvhd NN cord-005453-4057qib7 5880 17 were be VBD cord-005453-4057qib7 5880 18 20 20 CD cord-005453-4057qib7 5880 19 % % NN cord-005453-4057qib7 5880 20 , , , cord-005453-4057qib7 5880 21 35 35 CD cord-005453-4057qib7 5880 22 % % NN cord-005453-4057qib7 5880 23 , , , cord-005453-4057qib7 5880 24 72 72 CD cord-005453-4057qib7 5880 25 % % NN cord-005453-4057qib7 5880 26 respectively respectively RB cord-005453-4057qib7 5880 27 . . . cord-005453-4057qib7 5881 1 Four four CD cord-005453-4057qib7 5881 2 patients patient NNS cord-005453-4057qib7 5881 3 ( ( -LRB- cord-005453-4057qib7 5881 4 20 20 CD cord-005453-4057qib7 5881 5 % % NN cord-005453-4057qib7 5881 6 ) ) -RRB- cord-005453-4057qib7 5881 7 died die VBD cord-005453-4057qib7 5881 8 in in IN cord-005453-4057qib7 5881 9 90 90 CD cord-005453-4057qib7 5881 10 days day NNS cord-005453-4057qib7 5881 11 after after IN cord-005453-4057qib7 5881 12 using use VBG cord-005453-4057qib7 5881 13 MSCs msc NNS cord-005453-4057qib7 5881 14 from from IN cord-005453-4057qib7 5881 15 complications complication NNS cord-005453-4057qib7 5881 16 of of IN cord-005453-4057qib7 5881 17 aGVHD aGVHD NNP cord-005453-4057qib7 5881 18 . . . cord-005453-4057qib7 5882 1 Eleven eleven CD cord-005453-4057qib7 5882 2 of of IN cord-005453-4057qib7 5882 3 20 20 CD cord-005453-4057qib7 5882 4 patients patient NNS cord-005453-4057qib7 5882 5 ( ( -LRB- cord-005453-4057qib7 5882 6 55 55 CD cord-005453-4057qib7 5882 7 % % NN cord-005453-4057qib7 5882 8 ) ) -RRB- cord-005453-4057qib7 5882 9 were be VBD cord-005453-4057qib7 5882 10 still still RB cord-005453-4057qib7 5882 11 alive alive JJ cord-005453-4057qib7 5882 12 with with IN cord-005453-4057qib7 5882 13 a a DT cord-005453-4057qib7 5882 14 median median JJ cord-005453-4057qib7 5882 15 follow follow NN cord-005453-4057qib7 5882 16 - - HYPH cord-005453-4057qib7 5882 17 up up NN cord-005453-4057qib7 5882 18 of of IN cord-005453-4057qib7 5882 19 558 558 CD cord-005453-4057qib7 5882 20 days day NNS cord-005453-4057qib7 5882 21 ( ( -LRB- cord-005453-4057qib7 5882 22 range:171 range:171 NNP cord-005453-4057qib7 5882 23 - - HYPH cord-005453-4057qib7 5882 24 989 989 CD cord-005453-4057qib7 5882 25 days day NNS cord-005453-4057qib7 5882 26 ) ) -RRB- cord-005453-4057qib7 5882 27 after after IN cord-005453-4057qib7 5882 28 first first JJ cord-005453-4057qib7 5882 29 MSCs mscs NN cord-005453-4057qib7 5882 30 infusion infusion NN cord-005453-4057qib7 5882 31 . . . cord-005453-4057qib7 5883 1 One one CD cord-005453-4057qib7 5883 2 year year NN cord-005453-4057qib7 5883 3 estimated estimate VBD cord-005453-4057qib7 5883 4 probability probability NN cord-005453-4057qib7 5883 5 of of IN cord-005453-4057qib7 5883 6 overall overall JJ cord-005453-4057qib7 5883 7 survival survival NN cord-005453-4057qib7 5883 8 for for IN cord-005453-4057qib7 5883 9 patients patient NNS cord-005453-4057qib7 5883 10 achieving achieve VBG cord-005453-4057qib7 5883 11 OCR OCR NNP cord-005453-4057qib7 5883 12 and and CC cord-005453-4057qib7 5883 13 partial partial JJ cord-005453-4057qib7 5883 14 remission/ remission/ ADD cord-005453-4057qib7 5884 1 no no DT cord-005453-4057qib7 5884 2 remission remission NN cord-005453-4057qib7 5884 3 in in IN cord-005453-4057qib7 5884 4 90th 90th JJ cord-005453-4057qib7 5884 5 day day NN cord-005453-4057qib7 5884 6 of of IN cord-005453-4057qib7 5884 7 MSCs msc NNS cord-005453-4057qib7 5884 8 were be VBD cord-005453-4057qib7 5884 9 87.5 87.5 CD cord-005453-4057qib7 5884 10 % % NN cord-005453-4057qib7 5884 11 and and CC cord-005453-4057qib7 5884 12 20 20 CD cord-005453-4057qib7 5884 13 % % NN cord-005453-4057qib7 5884 14 , , , cord-005453-4057qib7 5884 15 respectively respectively RB cord-005453-4057qib7 5884 16 . . . cord-005453-4057qib7 5885 1 Conclusions conclusion NNS cord-005453-4057qib7 5885 2 : : : cord-005453-4057qib7 5886 1 In in IN cord-005453-4057qib7 5886 2 conclusion conclusion NN cord-005453-4057qib7 5886 3 , , , cord-005453-4057qib7 5886 4 MSCs MSCs NNP cord-005453-4057qib7 5886 5 appears appear VBZ cord-005453-4057qib7 5886 6 to to TO cord-005453-4057qib7 5886 7 be be VB cord-005453-4057qib7 5886 8 a a DT cord-005453-4057qib7 5886 9 safe safe JJ cord-005453-4057qib7 5886 10 and and CC cord-005453-4057qib7 5886 11 effective effective JJ cord-005453-4057qib7 5886 12 treatment treatment NN cord-005453-4057qib7 5886 13 option option NN cord-005453-4057qib7 5886 14 for for IN cord-005453-4057qib7 5886 15 pediatric pediatric JJ cord-005453-4057qib7 5886 16 patients patient NNS cord-005453-4057qib7 5886 17 with with IN cord-005453-4057qib7 5886 18 steroid steroid NN cord-005453-4057qib7 5886 19 refractory refractory JJ cord-005453-4057qib7 5886 20 aGVHD aGVHD NNP cord-005453-4057qib7 5886 21 . . . cord-005453-4057qib7 5887 1 Disclosure disclosure NN cord-005453-4057qib7 5887 2 : : : cord-005453-4057qib7 5887 3 Nothing nothing NN cord-005453-4057qib7 5887 4 to to TO cord-005453-4057qib7 5887 5 declare declare VB cord-005453-4057qib7 5887 6 Effect effect NN cord-005453-4057qib7 5887 7 of of IN cord-005453-4057qib7 5887 8 extracorporeal extracorporeal JJ cord-005453-4057qib7 5887 9 photopheresis photopheresis NN cord-005453-4057qib7 5887 10 on on IN cord-005453-4057qib7 5887 11 production production NN cord-005453-4057qib7 5887 12 of of IN cord-005453-4057qib7 5887 13 serum serum NN cord-005453-4057qib7 5887 14 elafin elafin NN cord-005453-4057qib7 5887 15 in in IN cord-005453-4057qib7 5887 16 chronic chronic JJ cord-005453-4057qib7 5887 17 graft graft NN cord-005453-4057qib7 5887 18 versus versus IN cord-005453-4057qib7 5887 19 host host NN cord-005453-4057qib7 5887 20 disease disease NN cord-005453-4057qib7 5887 21 Arun Arun NNP cord-005453-4057qib7 5887 22 Alfred Alfred NNP cord-005453-4057qib7 5887 23 1 1 CD cord-005453-4057qib7 5887 24 , , , cord-005453-4057qib7 5887 25 Charlotte Charlotte NNP cord-005453-4057qib7 5887 26 Burton Burton NNP cord-005453-4057qib7 5887 27 1 1 CD cord-005453-4057qib7 5887 28 , , , cord-005453-4057qib7 5887 29 Kathryn Kathryn NNP cord-005453-4057qib7 5887 30 Goddard Goddard NNP cord-005453-4057qib7 5887 31 1 1 CD cord-005453-4057qib7 5887 32 , , , cord-005453-4057qib7 5887 33 Nichloas Nichloas NNP cord-005453-4057qib7 5887 34 Matthews Matthews NNP cord-005453-4057qib7 5887 35 1 1 CD cord-005453-4057qib7 5887 36 Background Background NNP cord-005453-4057qib7 5887 37 : : : cord-005453-4057qib7 5888 1 Extracorporeal extracorporeal JJ cord-005453-4057qib7 5888 2 photopheresis photopheresis NN cord-005453-4057qib7 5888 3 ( ( -LRB- cord-005453-4057qib7 5888 4 ECP ECP NNP cord-005453-4057qib7 5888 5 ) ) -RRB- cord-005453-4057qib7 5888 6 is be VBZ cord-005453-4057qib7 5888 7 a a DT cord-005453-4057qib7 5888 8 second second JJ cord-005453-4057qib7 5888 9 line line NN cord-005453-4057qib7 5888 10 therapy therapy NN cord-005453-4057qib7 5888 11 for for IN cord-005453-4057qib7 5888 12 steroid steroid NN cord-005453-4057qib7 5888 13 refractory refractory JJ cord-005453-4057qib7 5888 14 , , , cord-005453-4057qib7 5888 15 dependent dependent JJ cord-005453-4057qib7 5888 16 or or CC cord-005453-4057qib7 5888 17 intolerant intolerant JJ cord-005453-4057qib7 5888 18 chronic chronic JJ cord-005453-4057qib7 5888 19 GVHD GVHD NNP cord-005453-4057qib7 5888 20 ( ( -LRB- cord-005453-4057qib7 5888 21 cGVHD cGVHD NNP cord-005453-4057qib7 5888 22 ) ) -RRB- cord-005453-4057qib7 5888 23 . . . cord-005453-4057qib7 5889 1 In in IN cord-005453-4057qib7 5889 2 order order NN cord-005453-4057qib7 5889 3 to to TO cord-005453-4057qib7 5889 4 guide guide VB cord-005453-4057qib7 5889 5 ECP ECP NNP cord-005453-4057qib7 5889 6 there there EX cord-005453-4057qib7 5889 7 is be VBZ cord-005453-4057qib7 5889 8 an an DT cord-005453-4057qib7 5889 9 unmet unmet JJ cord-005453-4057qib7 5889 10 need need NN cord-005453-4057qib7 5889 11 for for IN cord-005453-4057qib7 5889 12 predictive predictive JJ cord-005453-4057qib7 5889 13 and and CC cord-005453-4057qib7 5889 14 diagnostic diagnostic JJ cord-005453-4057qib7 5889 15 biomarkers biomarker NNS cord-005453-4057qib7 5889 16 . . . cord-005453-4057qib7 5890 1 Elafin Elafin NNP cord-005453-4057qib7 5890 2 is be VBZ cord-005453-4057qib7 5890 3 a a DT cord-005453-4057qib7 5890 4 serine serine NN cord-005453-4057qib7 5890 5 - - HYPH cord-005453-4057qib7 5890 6 protease protease NN cord-005453-4057qib7 5890 7 inhibitor inhibitor NN cord-005453-4057qib7 5890 8 primarily primarily RB cord-005453-4057qib7 5890 9 produced produce VBN cord-005453-4057qib7 5890 10 by by IN cord-005453-4057qib7 5890 11 epithelial epithelial JJ cord-005453-4057qib7 5890 12 cells cell NNS cord-005453-4057qib7 5890 13 , , , cord-005453-4057qib7 5890 14 particularly particularly RB cord-005453-4057qib7 5890 15 keratinocytes keratinocyte VBZ cord-005453-4057qib7 5890 16 in in IN cord-005453-4057qib7 5890 17 inflammatory inflammatory JJ cord-005453-4057qib7 5890 18 skin skin NN cord-005453-4057qib7 5890 19 diseases disease NNS cord-005453-4057qib7 5890 20 and and CC cord-005453-4057qib7 5890 21 plasma plasma NN cord-005453-4057qib7 5890 22 and and CC cord-005453-4057qib7 5890 23 epidermal epidermal JJ cord-005453-4057qib7 5890 24 elafin elafin NN cord-005453-4057qib7 5890 25 have have VBP cord-005453-4057qib7 5890 26 been be VBN cord-005453-4057qib7 5890 27 identified identify VBN cord-005453-4057qib7 5890 28 as as IN cord-005453-4057qib7 5890 29 biomarkers biomarker NNS cord-005453-4057qib7 5890 30 of of IN cord-005453-4057qib7 5890 31 skin skin NN cord-005453-4057qib7 5890 32 GVHD GVHD NNP cord-005453-4057qib7 5890 33 ( ( -LRB- cord-005453-4057qib7 5890 34 1 1 CD cord-005453-4057qib7 5890 35 , , , cord-005453-4057qib7 5890 36 2 2 CD cord-005453-4057qib7 5890 37 ) ) -RRB- cord-005453-4057qib7 5890 38 . . . cord-005453-4057qib7 5891 1 Since since IN cord-005453-4057qib7 5891 2 Skin Skin NNP cord-005453-4057qib7 5891 3 cGVHD cGVHD NNP cord-005453-4057qib7 5891 4 is be VBZ cord-005453-4057qib7 5891 5 noted note VBN cord-005453-4057qib7 5891 6 for for IN cord-005453-4057qib7 5891 7 a a DT cord-005453-4057qib7 5891 8 particularly particularly RB cord-005453-4057qib7 5891 9 high high JJ cord-005453-4057qib7 5891 10 response response NN cord-005453-4057qib7 5891 11 rate rate NN cord-005453-4057qib7 5891 12 to to IN cord-005453-4057qib7 5891 13 ECP ECP NNP cord-005453-4057qib7 5891 14 , , , cord-005453-4057qib7 5891 15 we -PRON- PRP cord-005453-4057qib7 5891 16 conducted conduct VBD cord-005453-4057qib7 5891 17 a a DT cord-005453-4057qib7 5891 18 study study NN cord-005453-4057qib7 5891 19 to to TO cord-005453-4057qib7 5891 20 investigate investigate VB cord-005453-4057qib7 5891 21 whether whether IN cord-005453-4057qib7 5891 22 ECP ECP NNP cord-005453-4057qib7 5891 23 affects affect VBZ cord-005453-4057qib7 5891 24 the the DT cord-005453-4057qib7 5891 25 production production NN cord-005453-4057qib7 5891 26 of of IN cord-005453-4057qib7 5891 27 elafin elafin NNP cord-005453-4057qib7 5891 28 . . . cord-005453-4057qib7 5892 1 Methods method NNS cord-005453-4057qib7 5892 2 : : : cord-005453-4057qib7 5892 3 Serum serum NN cord-005453-4057qib7 5892 4 samples sample NNS cord-005453-4057qib7 5892 5 were be VBD cord-005453-4057qib7 5892 6 collected collect VBN cord-005453-4057qib7 5892 7 from from IN cord-005453-4057qib7 5892 8 72 72 CD cord-005453-4057qib7 5892 9 cGVHD cgvhd NN cord-005453-4057qib7 5892 10 patients patient NNS cord-005453-4057qib7 5892 11 ( ( -LRB- cord-005453-4057qib7 5893 1 39 39 CD cord-005453-4057qib7 5893 2 male male NN cord-005453-4057qib7 5893 3 /33 /33 . cord-005453-4057qib7 5893 4 female female JJ cord-005453-4057qib7 5894 1 ; ; : cord-005453-4057qib7 5894 2 age age NN cord-005453-4057qib7 5894 3 range range NN cord-005453-4057qib7 5894 4 : : : cord-005453-4057qib7 5894 5 25 25 CD cord-005453-4057qib7 5894 6 - - SYM cord-005453-4057qib7 5894 7 74 74 CD cord-005453-4057qib7 5894 8 ) ) -RRB- cord-005453-4057qib7 5894 9 and and CC cord-005453-4057qib7 5894 10 17 17 CD cord-005453-4057qib7 5894 11 age age NN cord-005453-4057qib7 5894 12 - - HYPH cord-005453-4057qib7 5894 13 matched match VBN cord-005453-4057qib7 5894 14 healthy healthy JJ cord-005453-4057qib7 5894 15 controls control NNS cord-005453-4057qib7 5894 16 ( ( -LRB- cord-005453-4057qib7 5894 17 10 10 CD cord-005453-4057qib7 5894 18 male male JJ cord-005453-4057qib7 5894 19 / / SYM cord-005453-4057qib7 5894 20 7 7 CD cord-005453-4057qib7 5894 21 female female NN cord-005453-4057qib7 5894 22 ) ) -RRB- cord-005453-4057qib7 5894 23 before before IN cord-005453-4057qib7 5894 24 ECP ECP NNP cord-005453-4057qib7 5894 25 and and CC cord-005453-4057qib7 5894 26 at at IN cord-005453-4057qib7 5894 27 3 3 CD cord-005453-4057qib7 5894 28 month month NN cord-005453-4057qib7 5894 29 intervals interval NNS cord-005453-4057qib7 5894 30 up up IN cord-005453-4057qib7 5894 31 to to IN cord-005453-4057qib7 5894 32 1 1 CD cord-005453-4057qib7 5894 33 year year NN cord-005453-4057qib7 5894 34 . . . cord-005453-4057qib7 5895 1 Patients patient NNS cord-005453-4057qib7 5895 2 had have VBD cord-005453-4057qib7 5895 3 GVHD GVHD NNP cord-005453-4057qib7 5895 4 affecting affect VBG cord-005453-4057qib7 5895 5 skin skin NN cord-005453-4057qib7 5895 6 ( ( -LRB- cord-005453-4057qib7 5895 7 61/72 61/72 CD cord-005453-4057qib7 5895 8 ) ) -RRB- cord-005453-4057qib7 5895 9 , , , cord-005453-4057qib7 5895 10 mucosal mucosal JJ cord-005453-4057qib7 5895 11 membranes membrane NNS cord-005453-4057qib7 5895 12 ( ( -LRB- cord-005453-4057qib7 5895 13 16/ 16/ CD cord-005453-4057qib7 5895 14 72 72 CD cord-005453-4057qib7 5895 15 ) ) -RRB- cord-005453-4057qib7 5895 16 , , , cord-005453-4057qib7 5895 17 liver liver NN cord-005453-4057qib7 5895 18 ( ( -LRB- cord-005453-4057qib7 5895 19 14/72 14/72 CD cord-005453-4057qib7 5895 20 ) ) -RRB- cord-005453-4057qib7 5895 21 , , , cord-005453-4057qib7 5895 22 joints joint NNS cord-005453-4057qib7 5895 23 ( ( -LRB- cord-005453-4057qib7 5895 24 8/72 8/72 CD cord-005453-4057qib7 5895 25 ) ) -RRB- cord-005453-4057qib7 5895 26 , , , cord-005453-4057qib7 5895 27 gut gut NNP cord-005453-4057qib7 5895 28 ( ( -LRB- cord-005453-4057qib7 5895 29 17/72 17/72 CD cord-005453-4057qib7 5895 30 ) ) -RRB- cord-005453-4057qib7 5895 31 , , , cord-005453-4057qib7 5895 32 eye eye NN cord-005453-4057qib7 5895 33 ( ( -LRB- cord-005453-4057qib7 5895 34 8/72 8/72 CD cord-005453-4057qib7 5895 35 ) ) -RRB- cord-005453-4057qib7 5895 36 , , , cord-005453-4057qib7 5895 37 genital genital JJ cord-005453-4057qib7 5895 38 ( ( -LRB- cord-005453-4057qib7 5895 39 4/72 4/72 CD cord-005453-4057qib7 5895 40 ) ) -RRB- cord-005453-4057qib7 5895 41 , , , cord-005453-4057qib7 5895 42 and and CC cord-005453-4057qib7 5895 43 respiratory respiratory JJ cord-005453-4057qib7 5895 44 involvement involvement NN cord-005453-4057qib7 5895 45 ( ( -LRB- cord-005453-4057qib7 5895 46 4/72 4/72 CD cord-005453-4057qib7 5895 47 ) ) -RRB- cord-005453-4057qib7 5895 48 . . . cord-005453-4057qib7 5896 1 Serum serum NN cord-005453-4057qib7 5896 2 elafin elafin NN cord-005453-4057qib7 5896 3 was be VBD cord-005453-4057qib7 5896 4 assessed assess VBN cord-005453-4057qib7 5896 5 by by IN cord-005453-4057qib7 5896 6 ELISA ELISA NNP cord-005453-4057qib7 5896 7 ( ( -LRB- cord-005453-4057qib7 5896 8 R&D R&D NNP cord-005453-4057qib7 5896 9 Systems Systems NNP cord-005453-4057qib7 5896 10 ) ) -RRB- cord-005453-4057qib7 5896 11 . . . cord-005453-4057qib7 5897 1 Data datum NNS cord-005453-4057qib7 5897 2 were be VBD cord-005453-4057qib7 5897 3 analysed analyse VBN cord-005453-4057qib7 5897 4 using use VBG cord-005453-4057qib7 5897 5 GraphPad GraphPad NNP cord-005453-4057qib7 5897 6 Prism Prism NNP cord-005453-4057qib7 5897 7 6 6 CD cord-005453-4057qib7 5897 8 . . . cord-005453-4057qib7 5898 1 Statistical statistical JJ cord-005453-4057qib7 5898 2 tests test NNS cord-005453-4057qib7 5898 3 performed perform VBN cord-005453-4057qib7 5898 4 include include VBP cord-005453-4057qib7 5898 5 2-tailed 2-tailed CD cord-005453-4057qib7 5898 6 Mann Mann NNP cord-005453-4057qib7 5898 7 - - HYPH cord-005453-4057qib7 5898 8 Whitney Whitney NNP cord-005453-4057qib7 5898 9 , , , cord-005453-4057qib7 5898 10 Pearson Pearson NNP cord-005453-4057qib7 5898 11 's 's POS cord-005453-4057qib7 5898 12 correlation correlation NN cord-005453-4057qib7 5898 13 test test NN cord-005453-4057qib7 5898 14 , , , cord-005453-4057qib7 5898 15 and and CC cord-005453-4057qib7 5898 16 2-way 2-way JJ cord-005453-4057qib7 5898 17 ANOVA ANOVA NNP cord-005453-4057qib7 5898 18 with with IN cord-005453-4057qib7 5898 19 repeat repeat NN cord-005453-4057qib7 5898 20 measures measure NNS cord-005453-4057qib7 5898 21 , , , cord-005453-4057qib7 5898 22 as as IN cord-005453-4057qib7 5898 23 appropriate appropriate JJ cord-005453-4057qib7 5898 24 . . . cord-005453-4057qib7 5899 1 Results result NNS cord-005453-4057qib7 5899 2 : : : cord-005453-4057qib7 5899 3 Chronic chronic JJ cord-005453-4057qib7 5899 4 GVHD GVHD NNP cord-005453-4057qib7 5899 5 patients patient NNS cord-005453-4057qib7 5899 6 presenting present VBG cord-005453-4057qib7 5899 7 for for IN cord-005453-4057qib7 5899 8 ECP ECP NNP cord-005453-4057qib7 5899 9 had have VBD cord-005453-4057qib7 5899 10 significantly significantly RB cord-005453-4057qib7 5899 11 elevated elevate VBN cord-005453-4057qib7 5899 12 serum serum NN cord-005453-4057qib7 5899 13 levels level NNS cord-005453-4057qib7 5899 14 of of IN cord-005453-4057qib7 5899 15 elafin elafin NNP cord-005453-4057qib7 5900 1 ( ( -LRB- cord-005453-4057qib7 5900 2 P=0.0029 P=0.0029 NNS cord-005453-4057qib7 5900 3 ; ; : cord-005453-4057qib7 5900 4 median median NN cord-005453-4057qib7 5900 5 of of IN cord-005453-4057qib7 5900 6 22ng 22ng JJ cord-005453-4057qib7 5900 7 / / SYM cord-005453-4057qib7 5900 8 ml ml XX cord-005453-4057qib7 5900 9 , , , cord-005453-4057qib7 5900 10 IQR IQR NNP cord-005453-4057qib7 5900 11 15 15 CD cord-005453-4057qib7 5900 12 - - HYPH cord-005453-4057qib7 5900 13 45ng 45ng NN cord-005453-4057qib7 5900 14 / / SYM cord-005453-4057qib7 5900 15 ml ml NN cord-005453-4057qib7 5900 16 ) ) -RRB- cord-005453-4057qib7 5900 17 compared compare VBN cord-005453-4057qib7 5900 18 to to IN cord-005453-4057qib7 5900 19 healthy healthy JJ cord-005453-4057qib7 5900 20 controls control NNS cord-005453-4057qib7 5900 21 ( ( -LRB- cord-005453-4057qib7 5900 22 median median NN cord-005453-4057qib7 5900 23 of of IN cord-005453-4057qib7 5900 24 14 14 CD cord-005453-4057qib7 5900 25 ng ng NN cord-005453-4057qib7 5900 26 / / SYM cord-005453-4057qib7 5900 27 ml ml XX cord-005453-4057qib7 5900 28 , , , cord-005453-4057qib7 5900 29 IQR IQR NNP cord-005453-4057qib7 5900 30 9.6 9.6 CD cord-005453-4057qib7 5900 31 - - HYPH cord-005453-4057qib7 5900 32 18ng 18ng NNP cord-005453-4057qib7 5900 33 / / SYM cord-005453-4057qib7 5900 34 ml).While ml).While NNP cord-005453-4057qib7 5900 35 85 85 CD cord-005453-4057qib7 5900 36 % % NN cord-005453-4057qib7 5900 37 of of IN cord-005453-4057qib7 5900 38 patients patient NNS cord-005453-4057qib7 5900 39 had have VBD cord-005453-4057qib7 5900 40 skin skin NN cord-005453-4057qib7 5900 41 involvement involvement NN cord-005453-4057qib7 5900 42 , , , cord-005453-4057qib7 5900 43 only only RB cord-005453-4057qib7 5900 44 40 40 CD cord-005453-4057qib7 5900 45 % % NN cord-005453-4057qib7 5900 46 had have VBD cord-005453-4057qib7 5900 47 elafin elafin NN cord-005453-4057qib7 5900 48 levels level NNS cord-005453-4057qib7 5900 49 above above IN cord-005453-4057qib7 5900 50 the the DT cord-005453-4057qib7 5900 51 IQR IQR NNP cord-005453-4057qib7 5900 52 of of IN cord-005453-4057qib7 5900 53 healthy healthy JJ cord-005453-4057qib7 5900 54 controls control NNS cord-005453-4057qib7 5900 55 . . . cord-005453-4057qib7 5901 1 Where where WRB cord-005453-4057qib7 5901 2 disease disease NN cord-005453-4057qib7 5901 3 scores score NNS cord-005453-4057qib7 5901 4 were be VBD cord-005453-4057qib7 5901 5 available available JJ cord-005453-4057qib7 5901 6 ( ( -LRB- cord-005453-4057qib7 5901 7 n=25 n=25 NN cord-005453-4057qib7 5901 8 ) ) -RRB- cord-005453-4057qib7 5902 1 there there EX cord-005453-4057qib7 5902 2 were be VBD cord-005453-4057qib7 5902 3 no no DT cord-005453-4057qib7 5902 4 significant significant JJ cord-005453-4057qib7 5902 5 correlations correlation NNS cord-005453-4057qib7 5902 6 with with IN cord-005453-4057qib7 5902 7 Modified Modified NNP cord-005453-4057qib7 5902 8 Rodnans Rodnans NNP cord-005453-4057qib7 5902 9 ( ( -LRB- cord-005453-4057qib7 5902 10 r=0.19 r=0.19 NNP cord-005453-4057qib7 5902 11 ) ) -RRB- cord-005453-4057qib7 5902 12 or or CC cord-005453-4057qib7 5902 13 NIH NIH NNP cord-005453-4057qib7 5902 14 BSA BSA NNP cord-005453-4057qib7 5902 15 scores score NNS cord-005453-4057qib7 5902 16 ( ( -LRB- cord-005453-4057qib7 5902 17 r=0.37).Sub r=0.37).sub NN cord-005453-4057qib7 5902 18 - - HYPH cord-005453-4057qib7 5902 19 analysis analysis NN cord-005453-4057qib7 5902 20 was be VBD cord-005453-4057qib7 5902 21 performed perform VBN cord-005453-4057qib7 5902 22 by by IN cord-005453-4057qib7 5902 23 grouping group VBG cord-005453-4057qib7 5902 24 cGVHD cGVHD NNP cord-005453-4057qib7 5902 25 patients patient NNS cord-005453-4057qib7 5902 26 according accord VBG cord-005453-4057qib7 5902 27 to to IN cord-005453-4057qib7 5902 28 quartiles quartile NNS cord-005453-4057qib7 5902 29 of of IN cord-005453-4057qib7 5902 30 serum serum NN cord-005453-4057qib7 5902 31 elafin elafin NN cord-005453-4057qib7 5902 32 at at IN cord-005453-4057qib7 5902 33 pre pre JJ cord-005453-4057qib7 5902 34 - - JJ cord-005453-4057qib7 5902 35 ECP ecp JJ cord-005453-4057qib7 5902 36 baseline baseline NN cord-005453-4057qib7 5902 37 . . . cord-005453-4057qib7 5903 1 Retrospective retrospective JJ cord-005453-4057qib7 5903 2 analysis analysis NN cord-005453-4057qib7 5903 3 of of IN cord-005453-4057qib7 5903 4 patients patient NNS cord-005453-4057qib7 5903 5 after after IN cord-005453-4057qib7 5903 6 12 12 CD cord-005453-4057qib7 5903 7 months month NNS cord-005453-4057qib7 5903 8 of of IN cord-005453-4057qib7 5903 9 ECP ECP NNP cord-005453-4057qib7 5903 10 ( ( -LRB- cord-005453-4057qib7 5904 1 n=66 n=66 NNP cord-005453-4057qib7 5904 2 ) ) -RRB- cord-005453-4057qib7 5904 3 revealed reveal VBD cord-005453-4057qib7 5904 4 that that IN cord-005453-4057qib7 5904 5 those those DT cord-005453-4057qib7 5904 6 with with IN cord-005453-4057qib7 5904 7 serum serum NN cord-005453-4057qib7 5904 8 elafin elafin NN cord-005453-4057qib7 5904 9 levels level NNS cord-005453-4057qib7 5904 10 in in IN cord-005453-4057qib7 5904 11 the the DT cord-005453-4057qib7 5904 12 upper upper JJ cord-005453-4057qib7 5904 13 quartile quartile NN cord-005453-4057qib7 5905 1 ( ( -LRB- cord-005453-4057qib7 5905 2 elafin elafin NNP cord-005453-4057qib7 5905 3 hi hi UH cord-005453-4057qib7 5905 4 ) ) -RRB- cord-005453-4057qib7 5906 1 pre pre JJ cord-005453-4057qib7 5906 2 - - JJ cord-005453-4057qib7 5906 3 ECP ECP NNP cord-005453-4057qib7 5907 1 ( ( -LRB- cord-005453-4057qib7 5907 2 min min NNP cord-005453-4057qib7 5907 3 - - HYPH cord-005453-4057qib7 5907 4 max max NN cord-005453-4057qib7 5907 5 : : : cord-005453-4057qib7 5908 1 46 46 CD cord-005453-4057qib7 5908 2 - - HYPH cord-005453-4057qib7 5908 3 117ng 117ng NNP cord-005453-4057qib7 5908 4 / / SYM cord-005453-4057qib7 5908 5 ml ml NN cord-005453-4057qib7 5908 6 ) ) -RRB- cord-005453-4057qib7 5908 7 , , , cord-005453-4057qib7 5908 8 showed show VBD cord-005453-4057qib7 5908 9 a a DT cord-005453-4057qib7 5908 10 significant significant JJ cord-005453-4057qib7 5908 11 reduction reduction NN cord-005453-4057qib7 5908 12 after after IN cord-005453-4057qib7 5908 13 3 3 CD cord-005453-4057qib7 5908 14 months month NNS cord-005453-4057qib7 5908 15 of of IN cord-005453-4057qib7 5908 16 therapy therapy NN cord-005453-4057qib7 5908 17 ( ( -LRB- cord-005453-4057qib7 5908 18 p p NN cord-005453-4057qib7 5908 19 < < XX cord-005453-4057qib7 5908 20 0.05 0.05 CD cord-005453-4057qib7 5908 21 ; ; : cord-005453-4057qib7 5908 22 mean mean VB cord-005453-4057qib7 5908 23 + + CC cord-005453-4057qib7 5909 1 /-SD /-SD NNP cord-005453-4057qib7 5909 2 : : : cord-005453-4057qib7 5910 1 72ng 72ng NNP cord-005453-4057qib7 5910 2 / / SYM cord-005453-4057qib7 5910 3 ml ml NN cord-005453-4057qib7 5911 1 + + CC cord-005453-4057qib7 5912 1 /-26 /-26 . cord-005453-4057qib7 5913 1 ng ng NNP cord-005453-4057qib7 5913 2 / / SYM cord-005453-4057qib7 5913 3 ml ml NN cord-005453-4057qib7 5914 1 vs vs IN cord-005453-4057qib7 5914 2 53ng 53ng CD cord-005453-4057qib7 5915 1 /ml /ml . cord-005453-4057qib7 5916 1 + + CC cord-005453-4057qib7 5916 2 /-23ng /-23ng . cord-005453-4057qib7 5917 1 /ml /ml NFP cord-005453-4057qib7 5917 2 , , , cord-005453-4057qib7 5917 3 respectively respectively RB cord-005453-4057qib7 5917 4 ) ) -RRB- cord-005453-4057qib7 5917 5 , , , cord-005453-4057qib7 5917 6 which which WDT cord-005453-4057qib7 5917 7 was be VBD cord-005453-4057qib7 5917 8 sustained sustain VBN cord-005453-4057qib7 5917 9 up up RP cord-005453-4057qib7 5917 10 to to TO cord-005453-4057qib7 5917 11 12 12 CD cord-005453-4057qib7 5917 12 months month NNS cord-005453-4057qib7 5917 13 of of IN cord-005453-4057qib7 5917 14 ECP ECP NNP cord-005453-4057qib7 5917 15 ( ( -LRB- cord-005453-4057qib7 5917 16 P p NN cord-005453-4057qib7 5917 17 < < XX cord-005453-4057qib7 5917 18 0.0001 0.0001 CD cord-005453-4057qib7 5918 1 ; ; : cord-005453-4057qib7 5918 2 mean mean VB cord-005453-4057qib7 5918 3 + + CC cord-005453-4057qib7 5919 1 /-SD /-SD NNP cord-005453-4057qib7 5919 2 : : : cord-005453-4057qib7 5920 1 37 37 CD cord-005453-4057qib7 5920 2 ng/ ng/ NN cord-005453-4057qib7 5920 3 ml ml NNP cord-005453-4057qib7 5921 1 + + CC cord-005453-4057qib7 5922 1 /-20ng /-20ng NNP cord-005453-4057qib7 5922 2 / / SYM cord-005453-4057qib7 5922 3 ml ml NN cord-005453-4057qib7 5922 4 ) ) -RRB- cord-005453-4057qib7 5922 5 . . . cord-005453-4057qib7 5923 1 In in IN cord-005453-4057qib7 5923 2 contrast contrast NN cord-005453-4057qib7 5923 3 , , , cord-005453-4057qib7 5923 4 patients patient NNS cord-005453-4057qib7 5923 5 with with IN cord-005453-4057qib7 5923 6 elafin elafin NNP cord-005453-4057qib7 5923 7 levels level NNS cord-005453-4057qib7 5923 8 below below IN cord-005453-4057qib7 5923 9 the the DT cord-005453-4057qib7 5923 10 upper upper JJ cord-005453-4057qib7 5923 11 quartile quartile NNP cord-005453-4057qib7 5923 12 ( ( -LRB- cord-005453-4057qib7 5923 13 elafin elafin NNP cord-005453-4057qib7 5923 14 lo lo NNP cord-005453-4057qib7 5923 15 ) ) -RRB- cord-005453-4057qib7 5923 16 showed show VBD cord-005453-4057qib7 5923 17 no no DT cord-005453-4057qib7 5923 18 significant significant JJ cord-005453-4057qib7 5923 19 change change NN cord-005453-4057qib7 5923 20 ( ( -LRB- cord-005453-4057qib7 5924 1 mean mean VB cord-005453-4057qib7 5925 1 + + CC cord-005453-4057qib7 5926 1 /-SD /-SD NNP cord-005453-4057qib7 5926 2 : : : cord-005453-4057qib7 5927 1 21ng 21ng NNP cord-005453-4057qib7 5928 1 /ml /ml . cord-005453-4057qib7 5929 1 + + CC cord-005453-4057qib7 5930 1 /-11ng /-11ng NNP cord-005453-4057qib7 5930 2 / / SYM cord-005453-4057qib7 5930 3 ml ml XX cord-005453-4057qib7 5931 1 vs vs IN cord-005453-4057qib7 5931 2 26ng 26ng NNP cord-005453-4057qib7 5932 1 /ml /ml . cord-005453-4057qib7 5933 1 + + CC cord-005453-4057qib7 5933 2 /-20 /-20 . cord-005453-4057qib7 5934 1 ng ng NNP cord-005453-4057qib7 5934 2 / / SYM cord-005453-4057qib7 5934 3 ml ml XX cord-005453-4057qib7 5934 4 , , , cord-005453-4057qib7 5934 5 respectively respectively RB cord-005453-4057qib7 5934 6 ) ) -RRB- cord-005453-4057qib7 5934 7 . . . cord-005453-4057qib7 5935 1 Of of IN cord-005453-4057qib7 5935 2 note note VB cord-005453-4057qib7 5935 3 , , , cord-005453-4057qib7 5935 4 pre pre JJ cord-005453-4057qib7 5935 5 - - JJ cord-005453-4057qib7 5935 6 ECP ecp JJ cord-005453-4057qib7 5935 7 patients patient NNS cord-005453-4057qib7 5935 8 with with IN cord-005453-4057qib7 5935 9 elafin elafin NNP cord-005453-4057qib7 5935 10 below below IN cord-005453-4057qib7 5935 11 the the DT cord-005453-4057qib7 5935 12 median median NN cord-005453-4057qib7 5935 13 received receive VBD cord-005453-4057qib7 5935 14 significantly significantly RB cord-005453-4057qib7 5935 15 more more JJR cord-005453-4057qib7 5935 16 corticosteroid corticosteroid JJ cord-005453-4057qib7 5935 17 ( ( -LRB- cord-005453-4057qib7 5935 18 CS CS NNP cord-005453-4057qib7 5935 19 ) ) -RRB- cord-005453-4057qib7 5935 20 than than IN cord-005453-4057qib7 5935 21 those those DT cord-005453-4057qib7 5935 22 above above RB cord-005453-4057qib7 5935 23 , , , cord-005453-4057qib7 5935 24 ( ( -LRB- cord-005453-4057qib7 5935 25 P p NN cord-005453-4057qib7 5935 26 < < XX cord-005453-4057qib7 5935 27 0.05 0.05 CD cord-005453-4057qib7 5935 28 ; ; : cord-005453-4057qib7 5935 29 mean mean VB cord-005453-4057qib7 5935 30 + + CC cord-005453-4057qib7 5935 31 -SD -sd NN cord-005453-4057qib7 5935 32 : : : cord-005453-4057qib7 5936 1 27+/-18mg 27+/-18mg CD cord-005453-4057qib7 5936 2 / / SYM cord-005453-4057qib7 5936 3 d d NN cord-005453-4057qib7 5936 4 vs vs IN cord-005453-4057qib7 5936 5 16+/-16mg 16+/-16mg CD cord-005453-4057qib7 5936 6 / / SYM cord-005453-4057qib7 5936 7 d d NN cord-005453-4057qib7 5936 8 , , , cord-005453-4057qib7 5936 9 respectively respectively RB cord-005453-4057qib7 5936 10 ) ) -RRB- cord-005453-4057qib7 5936 11 , , , cord-005453-4057qib7 5936 12 which which WDT cord-005453-4057qib7 5936 13 was be VBD cord-005453-4057qib7 5936 14 significantly significantly RB cord-005453-4057qib7 5936 15 reduced reduce VBN cord-005453-4057qib7 5936 16 after after IN cord-005453-4057qib7 5936 17 3 3 CD cord-005453-4057qib7 5936 18 months month NNS cord-005453-4057qib7 5936 19 of of IN cord-005453-4057qib7 5936 20 ECP ECP NNP cord-005453-4057qib7 5936 21 ( ( -LRB- cord-005453-4057qib7 5936 22 P p NN cord-005453-4057qib7 5936 23 < < XX cord-005453-4057qib7 5936 24 0.001 0.001 XX cord-005453-4057qib7 5936 25 ; ; : cord-005453-4057qib7 5936 26 to to IN cord-005453-4057qib7 5936 27 13+/-10 13+/-10 CD cord-005453-4057qib7 5936 28 mg mg NNP cord-005453-4057qib7 5936 29 / / SYM cord-005453-4057qib7 5936 30 d d NNP cord-005453-4057qib7 5936 31 ) ) -RRB- cord-005453-4057qib7 5936 32 , , , cord-005453-4057qib7 5936 33 while while IN cord-005453-4057qib7 5936 34 CS CS NNP cord-005453-4057qib7 5936 35 dose dose NN cord-005453-4057qib7 5936 36 was be VBD cord-005453-4057qib7 5936 37 not not RB cord-005453-4057qib7 5936 38 significantly significantly RB cord-005453-4057qib7 5936 39 changed change VBN cord-005453-4057qib7 5936 40 in in IN cord-005453-4057qib7 5936 41 elafin elafin NNP cord-005453-4057qib7 5936 42 hi hi CD cord-005453-4057qib7 5936 43 patients patient NNS cord-005453-4057qib7 5936 44 until until IN cord-005453-4057qib7 5936 45 6 6 CD cord-005453-4057qib7 5936 46 months month NNS cord-005453-4057qib7 5936 47 ( ( -LRB- cord-005453-4057qib7 5936 48 P p NN cord-005453-4057qib7 5936 49 < < XX cord-005453-4057qib7 5936 50 0.05 0.05 CD cord-005453-4057qib7 5937 1 ; ; : cord-005453-4057qib7 5937 2 mean mean VB cord-005453-4057qib7 5937 3 + + CC cord-005453-4057qib7 5937 4 /-SD /-SD . cord-005453-4057qib7 5937 5 : : : cord-005453-4057qib7 5938 1 16mg 16mg NNP cord-005453-4057qib7 5938 2 / / SYM cord-005453-4057qib7 5938 3 d d NN cord-005453-4057qib7 5939 1 + + CC cord-005453-4057qib7 5939 2 /-16mg /-16mg NNS cord-005453-4057qib7 5939 3 / / NFP cord-005453-4057qib7 5939 4 d d XX cord-005453-4057qib7 5939 5 vs vs IN cord-005453-4057qib7 5939 6 6mg/ 6mg/ CD cord-005453-4057qib7 5940 1 d d LS cord-005453-4057qib7 5940 2 + + CC cord-005453-4057qib7 5940 3 /-5.5mg /-5.5mg NN cord-005453-4057qib7 5940 4 / / SYM cord-005453-4057qib7 5940 5 d d NN cord-005453-4057qib7 5940 6 , , , cord-005453-4057qib7 5940 7 respectively respectively RB cord-005453-4057qib7 5940 8 ) ) -RRB- cord-005453-4057qib7 5940 9 . . . cord-005453-4057qib7 5941 1 Conclusions conclusion NNS cord-005453-4057qib7 5941 2 : : : cord-005453-4057qib7 5942 1 Consistent consistent JJ cord-005453-4057qib7 5942 2 with with IN cord-005453-4057qib7 5942 3 recent recent JJ cord-005453-4057qib7 5942 4 data datum NNS cord-005453-4057qib7 5942 5 , , , cord-005453-4057qib7 5942 6 we -PRON- PRP cord-005453-4057qib7 5942 7 found find VBD cord-005453-4057qib7 5942 8 that that IN cord-005453-4057qib7 5942 9 serum serum NN cord-005453-4057qib7 5942 10 elafin elafin NN cord-005453-4057qib7 5942 11 is be VBZ cord-005453-4057qib7 5942 12 significantly significantly RB cord-005453-4057qib7 5942 13 elevated elevate VBN cord-005453-4057qib7 5942 14 in in IN cord-005453-4057qib7 5942 15 a a DT cord-005453-4057qib7 5942 16 subset subset NN cord-005453-4057qib7 5942 17 of of IN cord-005453-4057qib7 5942 18 cGVHD cgvhd NN cord-005453-4057qib7 5942 19 patients patient NNS cord-005453-4057qib7 5942 20 compared compare VBN cord-005453-4057qib7 5942 21 to to IN cord-005453-4057qib7 5942 22 healthy healthy JJ cord-005453-4057qib7 5942 23 controls control NNS cord-005453-4057qib7 5942 24 , , , cord-005453-4057qib7 5942 25 but but CC cord-005453-4057qib7 5942 26 did do VBD cord-005453-4057qib7 5942 27 not not RB cord-005453-4057qib7 5942 28 correlate correlate VB cord-005453-4057qib7 5942 29 with with IN cord-005453-4057qib7 5942 30 skin skin NN cord-005453-4057qib7 5942 31 disease disease NN cord-005453-4057qib7 5942 32 scores score NNS cord-005453-4057qib7 5942 33 . . . cord-005453-4057qib7 5943 1 ECP ECP NNP cord-005453-4057qib7 5943 2 administration administration NN cord-005453-4057qib7 5943 3 was be VBD cord-005453-4057qib7 5943 4 associated associate VBN cord-005453-4057qib7 5943 5 with with IN cord-005453-4057qib7 5943 6 a a DT cord-005453-4057qib7 5943 7 reduction reduction NN cord-005453-4057qib7 5943 8 in in IN cord-005453-4057qib7 5943 9 serum serum NN cord-005453-4057qib7 5943 10 elafin elafin NN cord-005453-4057qib7 5943 11 in in IN cord-005453-4057qib7 5943 12 the the DT cord-005453-4057qib7 5943 13 Elafin Elafin NNP cord-005453-4057qib7 5943 14 hi hi UH cord-005453-4057qib7 5943 15 subset subset JJ cord-005453-4057qib7 5943 16 . . . cord-005453-4057qib7 5944 1 Further further RB cord-005453-4057qib7 5944 2 , , , cord-005453-4057qib7 5944 3 elafin elafin NNP cord-005453-4057qib7 5944 4 lo lo NNP cord-005453-4057qib7 5944 5 and and CC cord-005453-4057qib7 5944 6 elafin elafin NNP cord-005453-4057qib7 5944 7 hi hi UH cord-005453-4057qib7 5944 8 patients patient NNS cord-005453-4057qib7 5944 9 tolerated tolerate VBD cord-005453-4057qib7 5944 10 different different JJ cord-005453-4057qib7 5944 11 rates rate NNS cord-005453-4057qib7 5944 12 of of IN cord-005453-4057qib7 5944 13 ECP ECP NNP cord-005453-4057qib7 5944 14 - - HYPH cord-005453-4057qib7 5944 15 mediated mediate VBN cord-005453-4057qib7 5944 16 tapering tapering NN cord-005453-4057qib7 5944 17 of of IN cord-005453-4057qib7 5944 18 CS CS NNP cord-005453-4057qib7 5944 19 immunosuppression immunosuppression NN cord-005453-4057qib7 5945 1 suggests suggest VBZ cord-005453-4057qib7 5945 2 pre pre JJ cord-005453-4057qib7 5945 3 - - JJ cord-005453-4057qib7 5945 4 ECP ecp JJ cord-005453-4057qib7 5945 5 elafin elafin NN cord-005453-4057qib7 5945 6 measurements measurement NNS cord-005453-4057qib7 5945 7 may may MD cord-005453-4057qib7 5945 8 have have VB cord-005453-4057qib7 5945 9 predictive predictive JJ cord-005453-4057qib7 5945 10 value value NN cord-005453-4057qib7 5945 11 . . . cord-005453-4057qib7 5946 1 References reference NNS cord-005453-4057qib7 5946 2 : : : cord-005453-4057qib7 5946 3 Background background NN cord-005453-4057qib7 5946 4 : : : cord-005453-4057qib7 5947 1 Allogenic allogenic JJ cord-005453-4057qib7 5947 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 5947 3 stem stem NN cord-005453-4057qib7 5947 4 cell cell NN cord-005453-4057qib7 5947 5 transplantation transplantation NN cord-005453-4057qib7 5947 6 ( ( -LRB- cord-005453-4057qib7 5947 7 HSCT HSCT NNP cord-005453-4057qib7 5947 8 ) ) -RRB- cord-005453-4057qib7 5947 9 is be VBZ cord-005453-4057qib7 5947 10 a a DT cord-005453-4057qib7 5947 11 potential potential JJ cord-005453-4057qib7 5947 12 curative curative JJ cord-005453-4057qib7 5947 13 treatment treatment NN cord-005453-4057qib7 5947 14 for for IN cord-005453-4057qib7 5947 15 many many JJ cord-005453-4057qib7 5947 16 malignant malignant JJ cord-005453-4057qib7 5947 17 and and CC cord-005453-4057qib7 5947 18 no no DT cord-005453-4057qib7 5947 19 malignant malignant JJ cord-005453-4057qib7 5947 20 hematologic hematologic JJ cord-005453-4057qib7 5947 21 diseases disease NNS cord-005453-4057qib7 5947 22 , , , cord-005453-4057qib7 5947 23 primary primary JJ cord-005453-4057qib7 5947 24 immunodeficiencies immunodeficiency NNS cord-005453-4057qib7 5947 25 and and CC cord-005453-4057qib7 5947 26 some some DT cord-005453-4057qib7 5947 27 metabolic metabolic JJ cord-005453-4057qib7 5947 28 and and CC cord-005453-4057qib7 5947 29 deposit deposit NN cord-005453-4057qib7 5947 30 diseases disease NNS cord-005453-4057qib7 5947 31 in in IN cord-005453-4057qib7 5947 32 children child NNS cord-005453-4057qib7 5947 33 . . . cord-005453-4057qib7 5948 1 Graft graft NN cord-005453-4057qib7 5948 2 versus versus IN cord-005453-4057qib7 5948 3 host host NN cord-005453-4057qib7 5948 4 disease disease NN cord-005453-4057qib7 5948 5 ( ( -LRB- cord-005453-4057qib7 5948 6 GVHD GVHD NNP cord-005453-4057qib7 5948 7 ) ) -RRB- cord-005453-4057qib7 5948 8 is be VBZ cord-005453-4057qib7 5948 9 a a DT cord-005453-4057qib7 5948 10 major major JJ cord-005453-4057qib7 5948 11 cause cause NN cord-005453-4057qib7 5948 12 of of IN cord-005453-4057qib7 5948 13 morbidity morbidity NN cord-005453-4057qib7 5948 14 and and CC cord-005453-4057qib7 5948 15 a a DT cord-005453-4057qib7 5948 16 leading leading JJ cord-005453-4057qib7 5948 17 cause cause NN cord-005453-4057qib7 5948 18 of of IN cord-005453-4057qib7 5948 19 non non JJ cord-005453-4057qib7 5948 20 - - JJ cord-005453-4057qib7 5948 21 relapse relapse JJ cord-005453-4057qib7 5948 22 mortality mortality NN cord-005453-4057qib7 5948 23 . . . cord-005453-4057qib7 5949 1 Corticosteroids corticosteroid NNS cord-005453-4057qib7 5949 2 are be VBP cord-005453-4057qib7 5949 3 the the DT cord-005453-4057qib7 5949 4 standard standard JJ cord-005453-4057qib7 5949 5 first first JJ cord-005453-4057qib7 5949 6 - - HYPH cord-005453-4057qib7 5949 7 line line NN cord-005453-4057qib7 5949 8 systemic systemic JJ cord-005453-4057qib7 5949 9 treatment treatment NN cord-005453-4057qib7 5949 10 for for IN cord-005453-4057qib7 5949 11 both both CC cord-005453-4057qib7 5949 12 acute acute JJ cord-005453-4057qib7 5949 13 and and CC cord-005453-4057qib7 5949 14 chronic chronic JJ cord-005453-4057qib7 5949 15 GVHD GVHD NNP cord-005453-4057qib7 5949 16 , , , cord-005453-4057qib7 5949 17 whereas whereas IN cord-005453-4057qib7 5949 18 no no DT cord-005453-4057qib7 5949 19 second second JJ cord-005453-4057qib7 5949 20 line line NN cord-005453-4057qib7 5949 21 option option NN cord-005453-4057qib7 5949 22 for for IN cord-005453-4057qib7 5949 23 corticosteroid corticosteroid NN cord-005453-4057qib7 5949 24 - - HYPH cord-005453-4057qib7 5949 25 refractory refractory JJ cord-005453-4057qib7 5949 26 patients patient NNS cord-005453-4057qib7 5949 27 is be VBZ cord-005453-4057qib7 5949 28 standardised standardised JJ cord-005453-4057qib7 5949 29 . . . cord-005453-4057qib7 5950 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5950 2 is be VBZ cord-005453-4057qib7 5950 3 a a DT cord-005453-4057qib7 5950 4 potent potent JJ cord-005453-4057qib7 5950 5 inhibitor inhibitor NN cord-005453-4057qib7 5950 6 of of IN cord-005453-4057qib7 5950 7 JAK JAK NNP cord-005453-4057qib7 5950 8 1/ 1/ CD cord-005453-4057qib7 5950 9 2 2 CD cord-005453-4057qib7 5950 10 showing show VBG cord-005453-4057qib7 5950 11 significant significant JJ cord-005453-4057qib7 5950 12 responses response NNS cord-005453-4057qib7 5950 13 in in IN cord-005453-4057qib7 5950 14 refractory refractory JJ cord-005453-4057qib7 5950 15 GVHD GVHD NNP cord-005453-4057qib7 5950 16 patients patient NNS cord-005453-4057qib7 5950 17 in in IN cord-005453-4057qib7 5950 18 recent recent JJ cord-005453-4057qib7 5950 19 reports report NNS cord-005453-4057qib7 5950 20 . . . cord-005453-4057qib7 5951 1 Methods method NNS cord-005453-4057qib7 5951 2 : : : cord-005453-4057qib7 5951 3 We -PRON- PRP cord-005453-4057qib7 5951 4 present present VBP cord-005453-4057qib7 5951 5 two two CD cord-005453-4057qib7 5951 6 centres centre NNS cord-005453-4057qib7 5951 7 experience experience NN cord-005453-4057qib7 5951 8 with with IN cord-005453-4057qib7 5951 9 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5951 10 for for IN cord-005453-4057qib7 5951 11 GVHD GVHD NNP cord-005453-4057qib7 5951 12 treatment treatment NN cord-005453-4057qib7 5951 13 in in IN cord-005453-4057qib7 5951 14 pediatric pediatric JJ cord-005453-4057qib7 5951 15 patients patient NNS cord-005453-4057qib7 5951 16 . . . cord-005453-4057qib7 5952 1 The the DT cord-005453-4057qib7 5952 2 study study NN cord-005453-4057qib7 5952 3 was be VBD cord-005453-4057qib7 5952 4 conducted conduct VBN cord-005453-4057qib7 5952 5 in in IN cord-005453-4057qib7 5952 6 two two CD cord-005453-4057qib7 5952 7 spanish spanish JJ cord-005453-4057qib7 5952 8 pediatric pediatric JJ cord-005453-4057qib7 5952 9 HSCT HSCT NNP cord-005453-4057qib7 5952 10 centres centre NNS cord-005453-4057qib7 5952 11 , , , cord-005453-4057qib7 5952 12 Hospital Hospital NNP cord-005453-4057qib7 5952 13 Vall Vall NNP cord-005453-4057qib7 5952 14 d'Hebron d'Hebron NNP cord-005453-4057qib7 5952 15 ( ( -LRB- cord-005453-4057qib7 5952 16 Barcelona Barcelona NNP cord-005453-4057qib7 5952 17 ) ) -RRB- cord-005453-4057qib7 5952 18 and and CC cord-005453-4057qib7 5952 19 Hospital Hospital NNP cord-005453-4057qib7 5952 20 Universitario Universitario NNP cord-005453-4057qib7 5952 21 La La NNP cord-005453-4057qib7 5952 22 Paz Paz NNP cord-005453-4057qib7 5952 23 ( ( -LRB- cord-005453-4057qib7 5952 24 Madrid Madrid NNP cord-005453-4057qib7 5952 25 ) ) -RRB- cord-005453-4057qib7 5952 26 . . . cord-005453-4057qib7 5953 1 All all DT cord-005453-4057qib7 5953 2 patients patient NNS cord-005453-4057qib7 5953 3 receiving receive VBG cord-005453-4057qib7 5953 4 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5953 5 since since IN cord-005453-4057qib7 5953 6 the the DT cord-005453-4057qib7 5953 7 drug drug NN cord-005453-4057qib7 5953 8 was be VBD cord-005453-4057qib7 5953 9 available available JJ cord-005453-4057qib7 5953 10 were be VBD cord-005453-4057qib7 5953 11 included include VBN cord-005453-4057qib7 5953 12 for for IN cord-005453-4057qib7 5953 13 retrospective retrospective JJ cord-005453-4057qib7 5953 14 analysis analysis NN cord-005453-4057qib7 5953 15 . . . cord-005453-4057qib7 5954 1 Results result NNS cord-005453-4057qib7 5954 2 : : : cord-005453-4057qib7 5955 1 Between between IN cord-005453-4057qib7 5955 2 March March NNP cord-005453-4057qib7 5955 3 2017 2017 CD cord-005453-4057qib7 5955 4 and and CC cord-005453-4057qib7 5955 5 December December NNP cord-005453-4057qib7 5955 6 2018 2018 CD cord-005453-4057qib7 5955 7 19 19 CD cord-005453-4057qib7 5955 8 pediatric pediatric JJ cord-005453-4057qib7 5955 9 patients patient NNS cord-005453-4057qib7 5955 10 with with IN cord-005453-4057qib7 5955 11 acute acute JJ cord-005453-4057qib7 5955 12 or or CC cord-005453-4057qib7 5955 13 chronic chronic JJ cord-005453-4057qib7 5955 14 GVHD GVHD NNP cord-005453-4057qib7 5955 15 with with IN cord-005453-4057qib7 5955 16 refractoriness refractoriness NN cord-005453-4057qib7 5955 17 to to IN cord-005453-4057qib7 5955 18 corticosteroids corticosteroid NNS cord-005453-4057qib7 5955 19 were be VBD cord-005453-4057qib7 5955 20 treated treat VBN cord-005453-4057qib7 5955 21 with with IN cord-005453-4057qib7 5955 22 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5955 23 , , , cord-005453-4057qib7 5955 24 in in IN cord-005453-4057qib7 5955 25 22 22 CD cord-005453-4057qib7 5955 26 different different JJ cord-005453-4057qib7 5955 27 episodes episode NNS cord-005453-4057qib7 5955 28 ( ( -LRB- cord-005453-4057qib7 5955 29 one one CD cord-005453-4057qib7 5955 30 patient patient NN cord-005453-4057qib7 5955 31 received receive VBD cord-005453-4057qib7 5955 32 it -PRON- PRP cord-005453-4057qib7 5955 33 in in IN cord-005453-4057qib7 5955 34 3 3 CD cord-005453-4057qib7 5955 35 different different JJ cord-005453-4057qib7 5955 36 moments moment NNS cord-005453-4057qib7 5955 37 , , , cord-005453-4057qib7 5955 38 and and CC cord-005453-4057qib7 5955 39 one one CD cord-005453-4057qib7 5955 40 patient patient NN cord-005453-4057qib7 5955 41 received receive VBD cord-005453-4057qib7 5955 42 it -PRON- PRP cord-005453-4057qib7 5955 43 in in IN cord-005453-4057qib7 5955 44 2 2 CD cord-005453-4057qib7 5955 45 ) ) -RRB- cord-005453-4057qib7 5955 46 . . . cord-005453-4057qib7 5956 1 Patient Patient NNP cord-005453-4057qib7 5956 2 's 's POS cord-005453-4057qib7 5956 3 sex sex NN cord-005453-4057qib7 5956 4 at at IN cord-005453-4057qib7 5956 5 birth birth NN cord-005453-4057qib7 5956 6 was be VBD cord-005453-4057qib7 5956 7 female female JJ cord-005453-4057qib7 5956 8 in in IN cord-005453-4057qib7 5956 9 11 11 CD cord-005453-4057qib7 5956 10 and and CC cord-005453-4057qib7 5956 11 male male NN cord-005453-4057qib7 5956 12 in in IN cord-005453-4057qib7 5956 13 8 8 CD cord-005453-4057qib7 5956 14 cases case NNS cord-005453-4057qib7 5956 15 . . . cord-005453-4057qib7 5957 1 Median median JJ cord-005453-4057qib7 5957 2 age age NN cord-005453-4057qib7 5957 3 at at IN cord-005453-4057qib7 5957 4 HSCT HSCT NNP cord-005453-4057qib7 5957 5 was be VBD cord-005453-4057qib7 5957 6 10,94 10,94 CD cord-005453-4057qib7 5957 7 years year NNS cord-005453-4057qib7 5957 8 ( ( -LRB- cord-005453-4057qib7 5957 9 0,79 0,79 CD cord-005453-4057qib7 5957 10 - - SYM cord-005453-4057qib7 5957 11 18,11 18,11 CD cord-005453-4057qib7 5957 12 ) ) -RRB- cord-005453-4057qib7 5957 13 . . . cord-005453-4057qib7 5958 1 Primary primary JJ cord-005453-4057qib7 5958 2 disease disease NN cord-005453-4057qib7 5958 3 was be VBD cord-005453-4057qib7 5958 4 malignant malignant JJ cord-005453-4057qib7 5958 5 in in IN cord-005453-4057qib7 5958 6 11 11 CD cord-005453-4057qib7 5958 7 patients patient NNS cord-005453-4057qib7 5958 8 and and CC cord-005453-4057qib7 5958 9 non non AFX cord-005453-4057qib7 5958 10 malignant malignant JJ cord-005453-4057qib7 5958 11 in in IN cord-005453-4057qib7 5958 12 8 8 CD cord-005453-4057qib7 5958 13 . . . cord-005453-4057qib7 5959 1 Median median JJ cord-005453-4057qib7 5959 2 time time NN cord-005453-4057qib7 5959 3 of of IN cord-005453-4057qib7 5959 4 GVHD GVHD NNP cord-005453-4057qib7 5959 5 diagnosis diagnosis NN cord-005453-4057qib7 5959 6 was be VBD cord-005453-4057qib7 5959 7 47,5 47,5 CD cord-005453-4057qib7 5959 8 days day NNS cord-005453-4057qib7 5959 9 ( ( -LRB- cord-005453-4057qib7 5959 10 6 6 CD cord-005453-4057qib7 5959 11 - - SYM cord-005453-4057qib7 5959 12 525 525 CD cord-005453-4057qib7 5959 13 ) ) -RRB- cord-005453-4057qib7 5959 14 . . . cord-005453-4057qib7 5960 1 All all DT cord-005453-4057qib7 5960 2 GVHD GVHD NNP cord-005453-4057qib7 5960 3 episodes episode NNS cord-005453-4057qib7 5960 4 were be VBD cord-005453-4057qib7 5960 5 treated treat VBN cord-005453-4057qib7 5960 6 with with IN cord-005453-4057qib7 5960 7 corticosteroids corticosteroid NNS cord-005453-4057qib7 5960 8 as as IN cord-005453-4057qib7 5960 9 first first JJ cord-005453-4057qib7 5960 10 line line NN cord-005453-4057qib7 5960 11 , , , cord-005453-4057qib7 5960 12 with with IN cord-005453-4057qib7 5960 13 maximum maximum JJ cord-005453-4057qib7 5960 14 doses dose NNS cord-005453-4057qib7 5960 15 between between IN cord-005453-4057qib7 5960 16 1 1 CD cord-005453-4057qib7 5960 17 - - SYM cord-005453-4057qib7 5960 18 5 5 CD cord-005453-4057qib7 5960 19 mg mg NNP cord-005453-4057qib7 5960 20 / / SYM cord-005453-4057qib7 5960 21 kg kg NNP cord-005453-4057qib7 5960 22 / / SYM cord-005453-4057qib7 5960 23 day day NN cord-005453-4057qib7 5960 24 ( ( -LRB- cord-005453-4057qib7 5960 25 the the DT cord-005453-4057qib7 5960 26 main main JJ cord-005453-4057qib7 5960 27 dose dose NN cord-005453-4057qib7 5960 28 used use VBN cord-005453-4057qib7 5960 29 was be VBD cord-005453-4057qib7 5960 30 2 2 CD cord-005453-4057qib7 5960 31 mg mg NNP cord-005453-4057qib7 5960 32 / / SYM cord-005453-4057qib7 5960 33 kg kg NNP cord-005453-4057qib7 5960 34 / / SYM cord-005453-4057qib7 5960 35 day day NN cord-005453-4057qib7 5960 36 , , , cord-005453-4057qib7 5960 37 15/22 15/22 CD cord-005453-4057qib7 5960 38 episodes episode NNS cord-005453-4057qib7 5960 39 ) ) -RRB- cord-005453-4057qib7 5960 40 . . . cord-005453-4057qib7 5961 1 Patients patient NNS cord-005453-4057qib7 5961 2 received receive VBD cord-005453-4057qib7 5961 3 a a DT cord-005453-4057qib7 5961 4 median median JJ cord-005453-4057qib7 5961 5 number number NN cord-005453-4057qib7 5961 6 of of IN cord-005453-4057qib7 5961 7 3,5 3,5 CD cord-005453-4057qib7 5961 8 ( ( -LRB- cord-005453-4057qib7 5961 9 2 2 CD cord-005453-4057qib7 5961 10 - - SYM cord-005453-4057qib7 5961 11 7 7 CD cord-005453-4057qib7 5961 12 ) ) -RRB- cord-005453-4057qib7 5961 13 previous previous JJ cord-005453-4057qib7 5961 14 lines line NNS cord-005453-4057qib7 5961 15 of of IN cord-005453-4057qib7 5961 16 treatment treatment NN cord-005453-4057qib7 5961 17 including include VBG cord-005453-4057qib7 5961 18 steroids steroid NNS cord-005453-4057qib7 5961 19 before before IN cord-005453-4057qib7 5961 20 starting start VBG cord-005453-4057qib7 5961 21 Ruxolinib Ruxolinib NNP cord-005453-4057qib7 5961 22 ; ; : cord-005453-4057qib7 5961 23 they -PRON- PRP cord-005453-4057qib7 5961 24 were be VBD cord-005453-4057qib7 5961 25 extracorporeal extracorporeal JJ cord-005453-4057qib7 5961 26 photopheresis photopheresis NN cord-005453-4057qib7 5961 27 ( ( -LRB- cord-005453-4057qib7 5961 28 19/22 19/22 CD cord-005453-4057qib7 5961 29 episodes episode NNS cord-005453-4057qib7 5961 30 ) ) -RRB- cord-005453-4057qib7 5961 31 , , , cord-005453-4057qib7 5961 32 sirolimus sirolimus NNP cord-005453-4057qib7 5961 33 ( ( -LRB- cord-005453-4057qib7 5961 34 7/22 7/22 CD cord-005453-4057qib7 5961 35 ) ) -RRB- cord-005453-4057qib7 5961 36 , , , cord-005453-4057qib7 5961 37 mesenchymal mesenchymal JJ cord-005453-4057qib7 5961 38 cells cell NNS cord-005453-4057qib7 5961 39 ( ( -LRB- cord-005453-4057qib7 5961 40 5/22 5/22 CD cord-005453-4057qib7 5961 41 ) ) -RRB- cord-005453-4057qib7 5962 1 Ruxolitinib ruxolitinib JJ cord-005453-4057qib7 5962 2 initiation initiation NN cord-005453-4057qib7 5962 3 was be VBD cord-005453-4057qib7 5962 4 indicated indicate VBN cord-005453-4057qib7 5962 5 for for IN cord-005453-4057qib7 5962 6 acute acute JJ cord-005453-4057qib7 5962 7 gut gut NN cord-005453-4057qib7 5962 8 refractory refractory JJ cord-005453-4057qib7 5962 9 / / SYM cord-005453-4057qib7 5962 10 steroid steroid NN cord-005453-4057qib7 5962 11 dependant dependant JJ cord-005453-4057qib7 5962 12 GVHD GVHD NNP cord-005453-4057qib7 5962 13 in in IN cord-005453-4057qib7 5962 14 9 9 CD cord-005453-4057qib7 5962 15 episodes episode NNS cord-005453-4057qib7 5962 16 and and CC cord-005453-4057qib7 5962 17 chronic chronic JJ cord-005453-4057qib7 5962 18 multisystemic multisystemic NN cord-005453-4057qib7 5962 19 in in IN cord-005453-4057qib7 5962 20 7 7 CD cord-005453-4057qib7 5962 21 episodes episode NNS cord-005453-4057qib7 5962 22 . . . cord-005453-4057qib7 5963 1 Other other JJ cord-005453-4057qib7 5963 2 indications indication NNS cord-005453-4057qib7 5963 3 were be VBD cord-005453-4057qib7 5963 4 chronic chronic JJ cord-005453-4057qib7 5963 5 lung lung NN cord-005453-4057qib7 5963 6 ( ( -LRB- cord-005453-4057qib7 5963 7 3/22 3/22 CD cord-005453-4057qib7 5963 8 episodes episode NNS cord-005453-4057qib7 5963 9 ) ) -RRB- cord-005453-4057qib7 5963 10 , , , cord-005453-4057qib7 5963 11 chronic chronic JJ cord-005453-4057qib7 5963 12 skin skin NN cord-005453-4057qib7 5963 13 ( ( -LRB- cord-005453-4057qib7 5963 14 2/22 2/22 CD cord-005453-4057qib7 5963 15 ) ) -RRB- cord-005453-4057qib7 5963 16 and and CC cord-005453-4057qib7 5963 17 acute acute JJ cord-005453-4057qib7 5963 18 skin skin NN cord-005453-4057qib7 5963 19 GVHD GVHD NNP cord-005453-4057qib7 5963 20 ( ( -LRB- cord-005453-4057qib7 5963 21 1/22 1/22 CD cord-005453-4057qib7 5963 22 ) ) -RRB- cord-005453-4057qib7 5963 23 . . . cord-005453-4057qib7 5964 1 Median median JJ cord-005453-4057qib7 5964 2 post post JJ cord-005453-4057qib7 5964 3 - - JJ cord-005453-4057qib7 5964 4 HSCT hsct JJ cord-005453-4057qib7 5964 5 time time NN cord-005453-4057qib7 5964 6 of of IN cord-005453-4057qib7 5964 7 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5964 8 start start NN cord-005453-4057qib7 5964 9 was be VBD cord-005453-4057qib7 5964 10 300 300 CD cord-005453-4057qib7 5964 11 days day NNS cord-005453-4057qib7 5964 12 . . . cord-005453-4057qib7 5965 1 Doses dose NNS cord-005453-4057qib7 5965 2 ranged range VBD cord-005453-4057qib7 5965 3 between between IN cord-005453-4057qib7 5965 4 2,5 2,5 CD cord-005453-4057qib7 5965 5 - - SYM cord-005453-4057qib7 5965 6 10 10 CD cord-005453-4057qib7 5965 7 mg/12h mg/12h NN cord-005453-4057qib7 5965 8 depending depend VBG cord-005453-4057qib7 5965 9 on on IN cord-005453-4057qib7 5965 10 age age NN cord-005453-4057qib7 5965 11 , , , cord-005453-4057qib7 5965 12 weight weight NN cord-005453-4057qib7 5965 13 , , , cord-005453-4057qib7 5965 14 and and CC cord-005453-4057qib7 5965 15 tolerance tolerance NN cord-005453-4057qib7 5965 16 ( ( -LRB- cord-005453-4057qib7 5965 17 hematologic hematologic JJ cord-005453-4057qib7 5965 18 and and CC cord-005453-4057qib7 5965 19 liver liver NN cord-005453-4057qib7 5965 20 toxicities toxicity NNS cord-005453-4057qib7 5965 21 ) ) -RRB- cord-005453-4057qib7 5965 22 . . . cord-005453-4057qib7 5966 1 Average average JJ cord-005453-4057qib7 5966 2 duration duration NN cord-005453-4057qib7 5966 3 of of IN cord-005453-4057qib7 5966 4 treatment treatment NN cord-005453-4057qib7 5966 5 was be VBD cord-005453-4057qib7 5966 6 186 186 CD cord-005453-4057qib7 5966 7 days day NNS cord-005453-4057qib7 5966 8 ( ( -LRB- cord-005453-4057qib7 5966 9 11 11 CD cord-005453-4057qib7 5966 10 - - SYM cord-005453-4057qib7 5966 11 616 616 CD cord-005453-4057qib7 5966 12 ) ) -RRB- cord-005453-4057qib7 5966 13 . . . cord-005453-4057qib7 5967 1 Complete complete JJ cord-005453-4057qib7 5967 2 response response NN cord-005453-4057qib7 5967 3 ( ( -LRB- cord-005453-4057qib7 5967 4 CR cr NN cord-005453-4057qib7 5967 5 ) ) -RRB- cord-005453-4057qib7 5967 6 rate rate NN cord-005453-4057qib7 5967 7 was be VBD cord-005453-4057qib7 5967 8 18,1 18,1 CD cord-005453-4057qib7 5967 9 % % NN cord-005453-4057qib7 5967 10 , , , cord-005453-4057qib7 5967 11 global global JJ cord-005453-4057qib7 5967 12 partial partial JJ cord-005453-4057qib7 5967 13 response response NN cord-005453-4057qib7 5967 14 ( ( -LRB- cord-005453-4057qib7 5967 15 PR pr NN cord-005453-4057qib7 5967 16 ) ) -RRB- cord-005453-4057qib7 5968 1 72,7 72,7 CD cord-005453-4057qib7 5968 2 % % NN cord-005453-4057qib7 5968 3 , , , cord-005453-4057qib7 5968 4 and and CC cord-005453-4057qib7 5968 5 no no DT cord-005453-4057qib7 5968 6 response response NN cord-005453-4057qib7 5968 7 ( ( -LRB- cord-005453-4057qib7 5968 8 NR nr NN cord-005453-4057qib7 5968 9 ) ) -RRB- cord-005453-4057qib7 5968 10 9 9 CD cord-005453-4057qib7 5968 11 % % NN cord-005453-4057qib7 5968 12 ( ( -LRB- cord-005453-4057qib7 5968 13 progression progression NN cord-005453-4057qib7 5968 14 in in IN cord-005453-4057qib7 5968 15 one one CD cord-005453-4057qib7 5968 16 patient patient NN cord-005453-4057qib7 5968 17 and and CC cord-005453-4057qib7 5968 18 recent recent JJ cord-005453-4057qib7 5968 19 treatment treatment NN cord-005453-4057qib7 5968 20 start start NN cord-005453-4057qib7 5968 21 in in IN cord-005453-4057qib7 5968 22 other other JJ cord-005453-4057qib7 5968 23 patient patient NN cord-005453-4057qib7 5968 24 ) ) -RRB- cord-005453-4057qib7 5968 25 . . . cord-005453-4057qib7 5969 1 Mean mean JJ cord-005453-4057qib7 5969 2 time time NN cord-005453-4057qib7 5969 3 to to TO cord-005453-4057qib7 5969 4 maximum maximum VB cord-005453-4057qib7 5969 5 response response NN cord-005453-4057qib7 5969 6 was be VBD cord-005453-4057qib7 5969 7 4 4 CD cord-005453-4057qib7 5969 8 weeks week NNS cord-005453-4057qib7 5969 9 . . . cord-005453-4057qib7 5970 1 Treatment treatment NN cord-005453-4057qib7 5970 2 stop stop NN cord-005453-4057qib7 5970 3 cause cause NN cord-005453-4057qib7 5970 4 was be VBD cord-005453-4057qib7 5970 5 CR cr NN cord-005453-4057qib7 5970 6 in in IN cord-005453-4057qib7 5970 7 2 2 CD cord-005453-4057qib7 5970 8 cases case NNS cord-005453-4057qib7 5970 9 , , , cord-005453-4057qib7 5970 10 infection infection NN cord-005453-4057qib7 5970 11 in in IN cord-005453-4057qib7 5970 12 4 4 CD cord-005453-4057qib7 5970 13 , , , cord-005453-4057qib7 5970 14 liver liver NN cord-005453-4057qib7 5970 15 toxicity toxicity NN cord-005453-4057qib7 5970 16 in in IN cord-005453-4057qib7 5970 17 1 1 CD cord-005453-4057qib7 5970 18 . . . cord-005453-4057qib7 5971 1 No no DT cord-005453-4057qib7 5971 2 severe severe JJ cord-005453-4057qib7 5971 3 side side NN cord-005453-4057qib7 5971 4 effects effect NNS cord-005453-4057qib7 5971 5 directly directly RB cord-005453-4057qib7 5971 6 related relate VBN cord-005453-4057qib7 5971 7 to to IN cord-005453-4057qib7 5971 8 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5971 9 treatment treatment NN cord-005453-4057qib7 5971 10 were be VBD cord-005453-4057qib7 5971 11 described describe VBN cord-005453-4057qib7 5971 12 . . . cord-005453-4057qib7 5972 1 Conclusions conclusion NNS cord-005453-4057qib7 5972 2 : : : cord-005453-4057qib7 5973 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 5973 2 has have VBZ cord-005453-4057qib7 5973 3 been be VBN cord-005453-4057qib7 5973 4 recently recently RB cord-005453-4057qib7 5973 5 introduced introduce VBN cord-005453-4057qib7 5973 6 as as IN cord-005453-4057qib7 5973 7 second second JJ cord-005453-4057qib7 5973 8 line line NN cord-005453-4057qib7 5973 9 strategy strategy NN cord-005453-4057qib7 5973 10 for for IN cord-005453-4057qib7 5973 11 rescuing rescue VBG cord-005453-4057qib7 5973 12 corticosteroid corticosteroid NN cord-005453-4057qib7 5973 13 - - HYPH cord-005453-4057qib7 5973 14 refractory refractory JJ cord-005453-4057qib7 5973 15 GVHD GVHD NNP cord-005453-4057qib7 5973 16 in in IN cord-005453-4057qib7 5973 17 pediatric pediatric JJ cord-005453-4057qib7 5973 18 patients patient NNS cord-005453-4057qib7 5973 19 . . . cord-005453-4057qib7 5974 1 While while IN cord-005453-4057qib7 5974 2 results result NNS cord-005453-4057qib7 5974 3 of of IN cord-005453-4057qib7 5974 4 randomized randomized JJ cord-005453-4057qib7 5974 5 trials trial NNS cord-005453-4057qib7 5974 6 are be VBP cord-005453-4057qib7 5974 7 lacking lack VBG cord-005453-4057qib7 5974 8 , , , cord-005453-4057qib7 5974 9 we -PRON- PRP cord-005453-4057qib7 5974 10 present present VBP cord-005453-4057qib7 5974 11 our -PRON- PRP$ cord-005453-4057qib7 5974 12 experience experience NN cord-005453-4057qib7 5974 13 ( ( -LRB- cord-005453-4057qib7 5974 14 two two CD cord-005453-4057qib7 5974 15 centres centre NNS cord-005453-4057qib7 5974 16 ) ) -RRB- cord-005453-4057qib7 5974 17 . . . cord-005453-4057qib7 5975 1 The the DT cord-005453-4057qib7 5975 2 main main JJ cord-005453-4057qib7 5975 3 indications indication NNS cord-005453-4057qib7 5975 4 for for IN cord-005453-4057qib7 5975 5 starting start VBG cord-005453-4057qib7 5975 6 treatment treatment NN cord-005453-4057qib7 5975 7 were be VBD cord-005453-4057qib7 5975 8 acute acute JJ cord-005453-4057qib7 5975 9 gut gut NN cord-005453-4057qib7 5975 10 and and CC cord-005453-4057qib7 5975 11 chronic chronic JJ cord-005453-4057qib7 5975 12 multisystemic multisystemic JJ cord-005453-4057qib7 5975 13 GVHD GVHD NNP cord-005453-4057qib7 5975 14 . . . cord-005453-4057qib7 5976 1 Most Most JJS cord-005453-4057qib7 5976 2 patients patient NNS cord-005453-4057qib7 5976 3 achieved achieve VBD cord-005453-4057qib7 5976 4 some some DT cord-005453-4057qib7 5976 5 grade grade NN cord-005453-4057qib7 5976 6 of of IN cord-005453-4057qib7 5976 7 response response NN cord-005453-4057qib7 5976 8 ( ( -LRB- cord-005453-4057qib7 5976 9 partial partial JJ cord-005453-4057qib7 5976 10 or or CC cord-005453-4057qib7 5976 11 complete complete JJ cord-005453-4057qib7 5976 12 ) ) -RRB- cord-005453-4057qib7 5976 13 , , , cord-005453-4057qib7 5976 14 allowing allow VBG cord-005453-4057qib7 5976 15 stopping stop VBG cord-005453-4057qib7 5976 16 or or CC cord-005453-4057qib7 5976 17 tapering taper VBG cord-005453-4057qib7 5976 18 corticosteroids corticosteroid NNS cord-005453-4057qib7 5976 19 . . . cord-005453-4057qib7 5977 1 Toxicity toxicity NN cord-005453-4057qib7 5977 2 profile profile NN cord-005453-4057qib7 5977 3 appears appear VBZ cord-005453-4057qib7 5977 4 to to TO cord-005453-4057qib7 5977 5 be be VB cord-005453-4057qib7 5977 6 acceptable acceptable JJ cord-005453-4057qib7 5977 7 . . . cord-005453-4057qib7 5978 1 Disclosure disclosure NN cord-005453-4057qib7 5978 2 : : : cord-005453-4057qib7 5978 3 Nothing nothing NN cord-005453-4057qib7 5978 4 to to TO cord-005453-4057qib7 5978 5 declare declare VB cord-005453-4057qib7 5978 6 . . . cord-005453-4057qib7 5979 1 Stability stability NN cord-005453-4057qib7 5979 2 of of IN cord-005453-4057qib7 5979 3 tacrolimus tacrolimus NN cord-005453-4057qib7 5979 4 concentration concentration NN cord-005453-4057qib7 5979 5 early early RB cord-005453-4057qib7 5979 6 after after IN cord-005453-4057qib7 5979 7 allogeneic allogeneic JJ cord-005453-4057qib7 5979 8 hematopoietic hematopoietic JJ cord-005453-4057qib7 5979 9 stem stem NN cord-005453-4057qib7 5979 10 cell cell NN cord-005453-4057qib7 5979 11 transplantation transplantation NN cord-005453-4057qib7 5979 12 reduces reduce VBZ cord-005453-4057qib7 5979 13 the the DT cord-005453-4057qib7 5979 14 risk risk NN cord-005453-4057qib7 5979 15 of of IN cord-005453-4057qib7 5979 16 acute acute JJ cord-005453-4057qib7 5979 17 GVHD GVHD NNP cord-005453-4057qib7 5979 18 Background background NN cord-005453-4057qib7 5979 19 : : : cord-005453-4057qib7 5980 1 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 5980 2 is be VBZ cord-005453-4057qib7 5980 3 used use VBN cord-005453-4057qib7 5980 4 as as IN cord-005453-4057qib7 5980 5 an an DT cord-005453-4057qib7 5980 6 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 5980 7 drug drug NN cord-005453-4057qib7 5980 8 after after IN cord-005453-4057qib7 5980 9 allogeneic allogeneic NN cord-005453-4057qib7 5980 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 5980 11 stem stem NN cord-005453-4057qib7 5980 12 cell cell NN cord-005453-4057qib7 5980 13 transplantation transplantation NN cord-005453-4057qib7 5980 14 ( ( -LRB- cord-005453-4057qib7 5980 15 allo allo NN cord-005453-4057qib7 5980 16 - - HYPH cord-005453-4057qib7 5980 17 HSCT HSCT NNP cord-005453-4057qib7 5980 18 ) ) -RRB- cord-005453-4057qib7 5980 19 . . . cord-005453-4057qib7 5981 1 It -PRON- PRP cord-005453-4057qib7 5981 2 is be VBZ cord-005453-4057qib7 5981 3 well well RB cord-005453-4057qib7 5981 4 known know VBN cord-005453-4057qib7 5981 5 that that IN cord-005453-4057qib7 5981 6 early early JJ cord-005453-4057qib7 5981 7 concentration concentration NN cord-005453-4057qib7 5981 8 level level NN cord-005453-4057qib7 5981 9 of of IN cord-005453-4057qib7 5981 10 tacrolimus tacrolimus NN cord-005453-4057qib7 5981 11 is be VBZ cord-005453-4057qib7 5981 12 correlated correlate VBN cord-005453-4057qib7 5981 13 with with IN cord-005453-4057qib7 5981 14 the the DT cord-005453-4057qib7 5981 15 risk risk NN cord-005453-4057qib7 5981 16 of of IN cord-005453-4057qib7 5981 17 acute acute JJ cord-005453-4057qib7 5981 18 graft graft NN cord-005453-4057qib7 5981 19 versus versus IN cord-005453-4057qib7 5981 20 host host NN cord-005453-4057qib7 5981 21 disease disease NN cord-005453-4057qib7 5981 22 ( ( -LRB- cord-005453-4057qib7 5981 23 aGVHD aGVHD NNP cord-005453-4057qib7 5981 24 ) ) -RRB- cord-005453-4057qib7 5981 25 , , , cord-005453-4057qib7 5981 26 however however RB cord-005453-4057qib7 5981 27 , , , cord-005453-4057qib7 5981 28 whether whether IN cord-005453-4057qib7 5981 29 range range NN cord-005453-4057qib7 5981 30 of of IN cord-005453-4057qib7 5981 31 standard standard JJ cord-005453-4057qib7 5981 32 derivation derivation NN cord-005453-4057qib7 5981 33 ( ( -LRB- cord-005453-4057qib7 5981 34 SD SD NNP cord-005453-4057qib7 5981 35 ) ) -RRB- cord-005453-4057qib7 5981 36 of of IN cord-005453-4057qib7 5981 37 early early JJ cord-005453-4057qib7 5981 38 tacrolimus tacrolimus NN cord-005453-4057qib7 5981 39 concentration concentration NN cord-005453-4057qib7 5981 40 after after IN cord-005453-4057qib7 5981 41 allo allo NN cord-005453-4057qib7 5981 42 - - HYPH cord-005453-4057qib7 5981 43 HSCT HSCT NNP cord-005453-4057qib7 5981 44 also also RB cord-005453-4057qib7 5981 45 affect affect VBP cord-005453-4057qib7 5981 46 to to IN cord-005453-4057qib7 5981 47 the the DT cord-005453-4057qib7 5981 48 risk risk NN cord-005453-4057qib7 5981 49 of of IN cord-005453-4057qib7 5981 50 aGVHD aGVHD NNP cord-005453-4057qib7 5981 51 still still RB cord-005453-4057qib7 5981 52 remains remain VBZ cord-005453-4057qib7 5981 53 unknown unknown JJ cord-005453-4057qib7 5981 54 . . . cord-005453-4057qib7 5982 1 Here here RB cord-005453-4057qib7 5982 2 , , , cord-005453-4057qib7 5982 3 we -PRON- PRP cord-005453-4057qib7 5982 4 investigate investigate VBP cord-005453-4057qib7 5982 5 the the DT cord-005453-4057qib7 5982 6 correlation correlation NN cord-005453-4057qib7 5982 7 between between IN cord-005453-4057qib7 5982 8 the the DT cord-005453-4057qib7 5982 9 range range NN cord-005453-4057qib7 5982 10 of of IN cord-005453-4057qib7 5982 11 SD SD NNP cord-005453-4057qib7 5982 12 of of IN cord-005453-4057qib7 5982 13 early early JJ cord-005453-4057qib7 5982 14 tacrolimus tacrolimus NN cord-005453-4057qib7 5982 15 concentration concentration NN cord-005453-4057qib7 5982 16 after after IN cord-005453-4057qib7 5982 17 donor donor NN cord-005453-4057qib7 5982 18 hematopoietic hematopoietic NN cord-005453-4057qib7 5982 19 cells cell NNS cord-005453-4057qib7 5982 20 engraftment engraftment NN cord-005453-4057qib7 5982 21 and and CC cord-005453-4057qib7 5982 22 the the DT cord-005453-4057qib7 5982 23 development development NN cord-005453-4057qib7 5982 24 of of IN cord-005453-4057qib7 5982 25 aGVHD aGVHD NNP cord-005453-4057qib7 5982 26 . . . cord-005453-4057qib7 5983 1 Methods method NNS cord-005453-4057qib7 5983 2 : : : cord-005453-4057qib7 5983 3 We -PRON- PRP cord-005453-4057qib7 5983 4 retrospectively retrospectively RB cord-005453-4057qib7 5983 5 assessed assess VBD cord-005453-4057qib7 5983 6 207 207 CD cord-005453-4057qib7 5983 7 patients patient NNS cord-005453-4057qib7 5983 8 who who WP cord-005453-4057qib7 5983 9 underwent undergo VBD cord-005453-4057qib7 5983 10 allo allo NN cord-005453-4057qib7 5983 11 - - HYPH cord-005453-4057qib7 5983 12 HSCT HSCT NNP cord-005453-4057qib7 5983 13 in in IN cord-005453-4057qib7 5983 14 our -PRON- PRP$ cord-005453-4057qib7 5983 15 hospital hospital NN cord-005453-4057qib7 5983 16 from from IN cord-005453-4057qib7 5983 17 2010 2010 CD cord-005453-4057qib7 5983 18 - - SYM cord-005453-4057qib7 5983 19 2017 2017 CD cord-005453-4057qib7 5983 20 . . . cord-005453-4057qib7 5984 1 All all DT cord-005453-4057qib7 5984 2 patients patient NNS cord-005453-4057qib7 5984 3 received receive VBD cord-005453-4057qib7 5984 4 standard standard JJ cord-005453-4057qib7 5984 5 GVHD GVHD NNP cord-005453-4057qib7 5984 6 prophylaxis prophylaxis NN cord-005453-4057qib7 5984 7 by by IN cord-005453-4057qib7 5984 8 continuous continuous JJ cord-005453-4057qib7 5984 9 intravenous intravenous NN cord-005453-4057qib7 5984 10 ( ( -LRB- cord-005453-4057qib7 5984 11 iv iv LS cord-005453-4057qib7 5984 12 ) ) -RRB- cord-005453-4057qib7 5984 13 TAC TAC NNP cord-005453-4057qib7 5984 14 with with IN cord-005453-4057qib7 5984 15 starting start VBG cord-005453-4057qib7 5984 16 dose dose NN cord-005453-4057qib7 5984 17 of of IN cord-005453-4057qib7 5984 18 0.02 0.02 CD cord-005453-4057qib7 5984 19 mg/ mg/ NNP cord-005453-4057qib7 5984 20 kg kg NNP cord-005453-4057qib7 5984 21 / / SYM cord-005453-4057qib7 5984 22 day day NN cord-005453-4057qib7 5984 23 from from IN cord-005453-4057qib7 5984 24 1 1 CD cord-005453-4057qib7 5984 25 day day NN cord-005453-4057qib7 5984 26 before before IN cord-005453-4057qib7 5984 27 allo allo NN cord-005453-4057qib7 5984 28 - - HYPH cord-005453-4057qib7 5984 29 HSCT HSCT NNP cord-005453-4057qib7 5984 30 ( ( -LRB- cord-005453-4057qib7 5984 31 day day NN cord-005453-4057qib7 5984 32 -1 -1 NNP cord-005453-4057qib7 5984 33 ) ) -RRB- cord-005453-4057qib7 5984 34 and and CC cord-005453-4057qib7 5984 35 iv iv NNP cord-005453-4057qib7 5984 36 methotrexate methotrexate NNP cord-005453-4057qib7 5984 37 on on IN cord-005453-4057qib7 5984 38 day day NN cord-005453-4057qib7 5984 39 1 1 CD cord-005453-4057qib7 5984 40 , , , cord-005453-4057qib7 5984 41 3 3 CD cord-005453-4057qib7 5984 42 , , , cord-005453-4057qib7 5984 43 6 6 CD cord-005453-4057qib7 5984 44 at at IN cord-005453-4057qib7 5984 45 dose dose NN cord-005453-4057qib7 5984 46 of of IN cord-005453-4057qib7 5984 47 10 10 CD cord-005453-4057qib7 5984 48 mg mg NNP cord-005453-4057qib7 5984 49 / / SYM cord-005453-4057qib7 5984 50 m m NN cord-005453-4057qib7 5984 51 2 2 CD cord-005453-4057qib7 5985 1 , , , cord-005453-4057qib7 5985 2 7 7 CD cord-005453-4057qib7 5985 3 mg mg NNP cord-005453-4057qib7 5985 4 / / SYM cord-005453-4057qib7 5985 5 m m NNP cord-005453-4057qib7 5985 6 2 2 CD cord-005453-4057qib7 5985 7 , , , cord-005453-4057qib7 5985 8 7 7 CD cord-005453-4057qib7 5985 9 mg mg NNP cord-005453-4057qib7 5985 10 / / SYM cord-005453-4057qib7 5985 11 m m NNP cord-005453-4057qib7 5985 12 2 2 CD cord-005453-4057qib7 5985 13 , , , cord-005453-4057qib7 5985 14 respectively respectively RB cord-005453-4057qib7 5985 15 . . . cord-005453-4057qib7 5986 1 TAC TAC NNP cord-005453-4057qib7 5986 2 dosage dosage NN cord-005453-4057qib7 5986 3 was be VBD cord-005453-4057qib7 5986 4 adjusted adjust VBN cord-005453-4057qib7 5986 5 to to TO cord-005453-4057qib7 5986 6 target target VB cord-005453-4057qib7 5986 7 the the DT cord-005453-4057qib7 5986 8 serum serum NN cord-005453-4057qib7 5986 9 concentration concentration NN cord-005453-4057qib7 5986 10 of of IN cord-005453-4057qib7 5986 11 8 8 CD cord-005453-4057qib7 5986 12 - - SYM cord-005453-4057qib7 5986 13 12 12 CD cord-005453-4057qib7 5986 14 ng ng NN cord-005453-4057qib7 5986 15 / / SYM cord-005453-4057qib7 5986 16 ml ml NN cord-005453-4057qib7 5986 17 until until IN cord-005453-4057qib7 5986 18 at at IN cord-005453-4057qib7 5986 19 least least JJS cord-005453-4057qib7 5986 20 day day NN cord-005453-4057qib7 5986 21 30 30 CD cord-005453-4057qib7 5986 22 and and CC cord-005453-4057qib7 5986 23 then then RB cord-005453-4057qib7 5986 24 tapered tapered JJ cord-005453-4057qib7 5986 25 . . . cord-005453-4057qib7 5987 1 To to TO cord-005453-4057qib7 5987 2 evaluate evaluate VB cord-005453-4057qib7 5987 3 the the DT cord-005453-4057qib7 5987 4 SD SD NNP cord-005453-4057qib7 5987 5 of of IN cord-005453-4057qib7 5987 6 weekly weekly JJ cord-005453-4057qib7 5987 7 tacrolimus tacrolimus NN cord-005453-4057qib7 5987 8 concentration concentration NN cord-005453-4057qib7 5987 9 , , , cord-005453-4057qib7 5987 10 the the DT cord-005453-4057qib7 5987 11 range range NN cord-005453-4057qib7 5987 12 of of IN cord-005453-4057qib7 5987 13 SD SD NNP cord-005453-4057qib7 5987 14 of of IN cord-005453-4057qib7 5987 15 tacrolimus tacrolimus NN cord-005453-4057qib7 5987 16 concentration concentration NN cord-005453-4057qib7 5987 17 at at IN cord-005453-4057qib7 5987 18 day1 day1 NNP cord-005453-4057qib7 5987 19 - - HYPH cord-005453-4057qib7 5987 20 7 7 NNP cord-005453-4057qib7 5987 21 ( ( -LRB- cord-005453-4057qib7 5987 22 week-1 week-1 NNP cord-005453-4057qib7 5987 23 ) ) -RRB- cord-005453-4057qib7 5987 24 , , , cord-005453-4057qib7 5987 25 day8 day8 VBN cord-005453-4057qib7 5987 26 - - HYPH cord-005453-4057qib7 5987 27 14(week-2 14(week-2 NNP cord-005453-4057qib7 5987 28 ) ) -RRB- cord-005453-4057qib7 5987 29 , , , cord-005453-4057qib7 5987 30 day15 day15 JJS cord-005453-4057qib7 5987 31 - - HYPH cord-005453-4057qib7 5987 32 21(week-3 21(week-3 NNP cord-005453-4057qib7 5987 33 ) ) -RRB- cord-005453-4057qib7 5987 34 and and CC cord-005453-4057qib7 5987 35 day22 day22 NNP cord-005453-4057qib7 5987 36 - - HYPH cord-005453-4057qib7 5987 37 28(week-4 28(week-4 CD cord-005453-4057qib7 5987 38 ) ) -RRB- cord-005453-4057qib7 5987 39 were be VBD cord-005453-4057qib7 5987 40 calculated calculate VBN cord-005453-4057qib7 5987 41 . . . cord-005453-4057qib7 5988 1 The the DT cord-005453-4057qib7 5988 2 difference difference NN cord-005453-4057qib7 5988 3 of of IN cord-005453-4057qib7 5988 4 the the DT cord-005453-4057qib7 5988 5 range range NN cord-005453-4057qib7 5988 6 of of IN cord-005453-4057qib7 5988 7 SD sd NN cord-005453-4057qib7 5988 8 between between IN cord-005453-4057qib7 5988 9 the the DT cord-005453-4057qib7 5988 10 2 2 CD cord-005453-4057qib7 5988 11 groups group NNS cord-005453-4057qib7 5988 12 that that WDT cord-005453-4057qib7 5988 13 develop develop VBP cord-005453-4057qib7 5988 14 or or CC cord-005453-4057qib7 5988 15 did do VBD cord-005453-4057qib7 5988 16 not not RB cord-005453-4057qib7 5988 17 develop develop VB cord-005453-4057qib7 5988 18 aGVHD aGVHD NNP cord-005453-4057qib7 5988 19 was be VBD cord-005453-4057qib7 5988 20 compared compare VBN cord-005453-4057qib7 5988 21 by by IN cord-005453-4057qib7 5988 22 using use VBG cord-005453-4057qib7 5988 23 Mann Mann NNP cord-005453-4057qib7 5988 24 - - HYPH cord-005453-4057qib7 5988 25 Whitney Whitney NNP cord-005453-4057qib7 5988 26 U U NNP cord-005453-4057qib7 5988 27 test test NN cord-005453-4057qib7 5988 28 . . . cord-005453-4057qib7 5989 1 Multivariate multivariate JJ cord-005453-4057qib7 5989 2 analysis analysis NN cord-005453-4057qib7 5989 3 was be VBD cord-005453-4057qib7 5989 4 performed perform VBN cord-005453-4057qib7 5989 5 by by IN cord-005453-4057qib7 5989 6 using use VBG cord-005453-4057qib7 5989 7 multiple multiple JJ cord-005453-4057qib7 5989 8 logistic logistic JJ cord-005453-4057qib7 5989 9 regression regression NN cord-005453-4057qib7 5989 10 analysis analysis NN cord-005453-4057qib7 5989 11 . . . cord-005453-4057qib7 5990 1 Patients patient NNS cord-005453-4057qib7 5990 2 had have VBD cord-005453-4057qib7 5990 3 given give VBN cord-005453-4057qib7 5990 4 written write VBN cord-005453-4057qib7 5990 5 consent consent NN cord-005453-4057qib7 5990 6 allowing allow VBG cord-005453-4057qib7 5990 7 the the DT cord-005453-4057qib7 5990 8 use use NN cord-005453-4057qib7 5990 9 of of IN cord-005453-4057qib7 5990 10 medical medical JJ cord-005453-4057qib7 5990 11 records record NNS cord-005453-4057qib7 5990 12 for for IN cord-005453-4057qib7 5990 13 research research NN cord-005453-4057qib7 5990 14 , , , cord-005453-4057qib7 5990 15 in in IN cord-005453-4057qib7 5990 16 accordance accordance NN cord-005453-4057qib7 5990 17 with with IN cord-005453-4057qib7 5990 18 the the DT cord-005453-4057qib7 5990 19 Declaration Declaration NNP cord-005453-4057qib7 5990 20 of of IN cord-005453-4057qib7 5990 21 Helsinki Helsinki NNP cord-005453-4057qib7 5990 22 , , , cord-005453-4057qib7 5990 23 and and CC cord-005453-4057qib7 5990 24 the the DT cord-005453-4057qib7 5990 25 Institutional Institutional NNP cord-005453-4057qib7 5990 26 Review Review NNP cord-005453-4057qib7 5990 27 Board Board NNP cord-005453-4057qib7 5990 28 approved approve VBD cord-005453-4057qib7 5990 29 the the DT cord-005453-4057qib7 5990 30 study study NN cord-005453-4057qib7 5990 31 . . . cord-005453-4057qib7 5991 1 Results result NNS cord-005453-4057qib7 5991 2 : : : cord-005453-4057qib7 5992 1 There there EX cord-005453-4057qib7 5992 2 were be VBD cord-005453-4057qib7 5992 3 114 114 CD cord-005453-4057qib7 5992 4 males male NNS cord-005453-4057qib7 5992 5 and and CC cord-005453-4057qib7 5992 6 93 93 CD cord-005453-4057qib7 5992 7 females female NNS cord-005453-4057qib7 5992 8 and and CC cord-005453-4057qib7 5992 9 the the DT cord-005453-4057qib7 5992 10 median median JJ cord-005453-4057qib7 5992 11 age age NN cord-005453-4057qib7 5992 12 was be VBD cord-005453-4057qib7 5992 13 45 45 CD cord-005453-4057qib7 5992 14 years year NNS cord-005453-4057qib7 5992 15 ( ( -LRB- cord-005453-4057qib7 5992 16 range range NN cord-005453-4057qib7 5992 17 , , , cord-005453-4057qib7 5992 18 16 16 CD cord-005453-4057qib7 5992 19 to to TO cord-005453-4057qib7 5992 20 68 68 CD cord-005453-4057qib7 5992 21 years year NNS cord-005453-4057qib7 5992 22 ) ) -RRB- cord-005453-4057qib7 5992 23 . . . cord-005453-4057qib7 5993 1 The the DT cord-005453-4057qib7 5993 2 risks risk NNS cord-005453-4057qib7 5993 3 of of IN cord-005453-4057qib7 5993 4 disease disease NN cord-005453-4057qib7 5993 5 were be VBD cord-005453-4057qib7 5993 6 low low JJ cord-005453-4057qib7 5993 7 - - HYPH cord-005453-4057qib7 5993 8 standard standard NN cord-005453-4057qib7 5993 9 in in IN cord-005453-4057qib7 5993 10 141 141 CD cord-005453-4057qib7 5993 11 and and CC cord-005453-4057qib7 5993 12 high high JJ cord-005453-4057qib7 5993 13 in in IN cord-005453-4057qib7 5993 14 66 66 CD cord-005453-4057qib7 5993 15 pts pt NNS cord-005453-4057qib7 5993 16 . . . cord-005453-4057qib7 5994 1 The the DT cord-005453-4057qib7 5994 2 number number NN cord-005453-4057qib7 5994 3 of of IN cord-005453-4057qib7 5994 4 donors donor NNS cord-005453-4057qib7 5994 5 were be VBD cord-005453-4057qib7 5994 6 in in IN cord-005453-4057qib7 5994 7 6 6 CD cord-005453-4057qib7 5994 8 HLA HLA NNP cord-005453-4057qib7 5994 9 - - HYPH cord-005453-4057qib7 5994 10 identical identical JJ cord-005453-4057qib7 5994 11 sibling sibling NN cord-005453-4057qib7 5994 12 , , , cord-005453-4057qib7 5994 13 13 13 CD cord-005453-4057qib7 5994 14 in in IN cord-005453-4057qib7 5994 15 HLA HLA NNP cord-005453-4057qib7 5994 16 - - HYPH cord-005453-4057qib7 5994 17 mismatched mismatch VBN cord-005453-4057qib7 5994 18 related related JJ cord-005453-4057qib7 5994 19 donor donor NN cord-005453-4057qib7 5994 20 , , , cord-005453-4057qib7 5994 21 81 81 CD cord-005453-4057qib7 5994 22 in in IN cord-005453-4057qib7 5994 23 HLA HLA NNP cord-005453-4057qib7 5994 24 - - HYPH cord-005453-4057qib7 5994 25 matched match VBN cord-005453-4057qib7 5994 26 unrelated unrelated JJ cord-005453-4057qib7 5994 27 donor donor NN cord-005453-4057qib7 5994 28 and and CC cord-005453-4057qib7 5994 29 107 107 CD cord-005453-4057qib7 5994 30 in in IN cord-005453-4057qib7 5994 31 HLA HLA NNP cord-005453-4057qib7 5994 32 - - HYPH cord-005453-4057qib7 5994 33 mismatched mismatch VBN cord-005453-4057qib7 5994 34 unrelated unrelated JJ cord-005453-4057qib7 5994 35 donor donor NN cord-005453-4057qib7 5994 36 . . . cord-005453-4057qib7 5995 1 Thirty thirty CD cord-005453-4057qib7 5995 2 - - HYPH cord-005453-4057qib7 5995 3 seven seven CD cord-005453-4057qib7 5995 4 patients patient NNS cord-005453-4057qib7 5995 5 developed develop VBD cord-005453-4057qib7 5995 6 aGVHD aGVHD NNP cord-005453-4057qib7 5995 7 ( ( -LRB- cord-005453-4057qib7 5995 8 Grade Grade NNP cord-005453-4057qib7 5995 9 I I NNP cord-005453-4057qib7 5995 10 - - HYPH cord-005453-4057qib7 5995 11 II II NNP cord-005453-4057qib7 5995 12 ; ; : cord-005453-4057qib7 5995 13 28 28 CD cord-005453-4057qib7 5995 14 , , , cord-005453-4057qib7 5995 15 GradeIII GradeIII NNP cord-005453-4057qib7 5995 16 - - HYPH cord-005453-4057qib7 5995 17 IV IV NNP cord-005453-4057qib7 5995 18 ; ; : cord-005453-4057qib7 5995 19 9 9 CD cord-005453-4057qib7 5995 20 patients patient NNS cord-005453-4057qib7 5995 21 ) ) -RRB- cord-005453-4057qib7 5995 22 . . . cord-005453-4057qib7 5996 1 As as IN cord-005453-4057qib7 5996 2 a a DT cord-005453-4057qib7 5996 3 result result NN cord-005453-4057qib7 5996 4 , , , cord-005453-4057qib7 5996 5 the the DT cord-005453-4057qib7 5996 6 wide wide JJ cord-005453-4057qib7 5996 7 range range NN cord-005453-4057qib7 5996 8 of of IN cord-005453-4057qib7 5996 9 SD sd NN cord-005453-4057qib7 5996 10 at at IN cord-005453-4057qib7 5996 11 week-3 week-3 NNP cord-005453-4057qib7 5996 12 significantly significantly RB cord-005453-4057qib7 5996 13 increased increase VBD cord-005453-4057qib7 5996 14 the the DT cord-005453-4057qib7 5996 15 risk risk NN cord-005453-4057qib7 5996 16 of of IN cord-005453-4057qib7 5996 17 aGVHD aGVHD NNP cord-005453-4057qib7 5996 18 ( ( -LRB- cord-005453-4057qib7 5996 19 aGVHD aGVHD NNP cord-005453-4057qib7 5996 20 - - HYPH cord-005453-4057qib7 5996 21 group group NN cord-005453-4057qib7 5996 22 ; ; : cord-005453-4057qib7 5996 23 1.178±0.8159 1.178±0.8159 NNP cord-005453-4057qib7 5996 24 ng ng NNP cord-005453-4057qib7 5996 25 / / SYM cord-005453-4057qib7 5996 26 ml ml XX cord-005453-4057qib7 5996 27 , , , cord-005453-4057qib7 5996 28 aGVHD+ aGVHD+ NNP cord-005453-4057qib7 5996 29 group group NN cord-005453-4057qib7 5996 30 ; ; : cord-005453-4057qib7 5996 31 1.447±0.7359 1.447±0.7359 CD cord-005453-4057qib7 5996 32 ng ng NN cord-005453-4057qib7 5996 33 / / SYM cord-005453-4057qib7 5996 34 ml ml NN cord-005453-4057qib7 5996 35 , , , cord-005453-4057qib7 5996 36 p=0.02 p=0.02 NNP cord-005453-4057qib7 5996 37 ) ) -RRB- cord-005453-4057qib7 5996 38 . . . cord-005453-4057qib7 5997 1 Multivariate multivariate JJ cord-005453-4057qib7 5997 2 analysis analysis NN cord-005453-4057qib7 5997 3 demonstrated demonstrate VBD cord-005453-4057qib7 5997 4 that that IN cord-005453-4057qib7 5997 5 narrow narrow JJ cord-005453-4057qib7 5997 6 range range NN cord-005453-4057qib7 5997 7 of of IN cord-005453-4057qib7 5997 8 SD sd NN cord-005453-4057qib7 5997 9 of of IN cord-005453-4057qib7 5997 10 tacrolimus tacrolimus NN cord-005453-4057qib7 5997 11 concentration concentration NN cord-005453-4057qib7 5997 12 at at IN cord-005453-4057qib7 5997 13 week-3 week-3 NNP cord-005453-4057qib7 5997 14 reduce reduce VB cord-005453-4057qib7 5997 15 the the DT cord-005453-4057qib7 5997 16 risk risk NN cord-005453-4057qib7 5997 17 of of IN cord-005453-4057qib7 5997 18 aGVHD aGVHD NNP cord-005453-4057qib7 5997 19 ( ( -LRB- cord-005453-4057qib7 5997 20 OR=4.19 or=4.19 XX cord-005453-4057qib7 5998 1 ; ; : cord-005453-4057qib7 5998 2 95 95 CD cord-005453-4057qib7 5998 3 % % NN cord-005453-4057qib7 5998 4 CI ci NN cord-005453-4057qib7 5998 5 : : : cord-005453-4057qib7 5998 6 1.59 1.59 CD cord-005453-4057qib7 5998 7 - - SYM cord-005453-4057qib7 5998 8 14.80 14.80 CD cord-005453-4057qib7 5998 9 ; ; : cord-005453-4057qib7 5998 10 p=0.005 p=0.005 NNP cord-005453-4057qib7 5998 11 ) ) -RRB- cord-005453-4057qib7 5998 12 . . . cord-005453-4057qib7 5999 1 There there EX cord-005453-4057qib7 5999 2 were be VBD cord-005453-4057qib7 5999 3 no no DT cord-005453-4057qib7 5999 4 correlation correlation NN cord-005453-4057qib7 5999 5 between between IN cord-005453-4057qib7 5999 6 gender gender NN cord-005453-4057qib7 5999 7 , , , cord-005453-4057qib7 5999 8 age age NN cord-005453-4057qib7 5999 9 , , , cord-005453-4057qib7 5999 10 disease disease NN cord-005453-4057qib7 5999 11 status status NN cord-005453-4057qib7 5999 12 , , , cord-005453-4057qib7 5999 13 HLA HLA NNP cord-005453-4057qib7 5999 14 with with IN cord-005453-4057qib7 5999 15 the the DT cord-005453-4057qib7 5999 16 development development NN cord-005453-4057qib7 5999 17 of of IN cord-005453-4057qib7 5999 18 aGVHD aGVHD NNP cord-005453-4057qib7 5999 19 . . . cord-005453-4057qib7 6000 1 Conclusions conclusion NNS cord-005453-4057qib7 6000 2 : : : cord-005453-4057qib7 6001 1 The the DT cord-005453-4057qib7 6001 2 range range NN cord-005453-4057qib7 6001 3 of of IN cord-005453-4057qib7 6001 4 SD sd NN cord-005453-4057qib7 6001 5 at at IN cord-005453-4057qib7 6001 6 week-3 week-3 NNP cord-005453-4057qib7 6001 7 , , , cord-005453-4057qib7 6001 8 an an DT cord-005453-4057qib7 6001 9 engraftment engraftment NN cord-005453-4057qib7 6001 10 phase phase NN cord-005453-4057qib7 6001 11 of of IN cord-005453-4057qib7 6001 12 donor donor NN cord-005453-4057qib7 6001 13 hematopoietic hematopoietic NN cord-005453-4057qib7 6001 14 cells cell NNS cord-005453-4057qib7 6001 15 , , , cord-005453-4057qib7 6001 16 was be VBD cord-005453-4057qib7 6001 17 significantly significantly RB cord-005453-4057qib7 6001 18 correlated correlate VBN cord-005453-4057qib7 6001 19 with with IN cord-005453-4057qib7 6001 20 the the DT cord-005453-4057qib7 6001 21 development development NN cord-005453-4057qib7 6001 22 of of IN cord-005453-4057qib7 6001 23 aGVHD aGVHD NNP cord-005453-4057qib7 6001 24 . . . cord-005453-4057qib7 6002 1 Fine fine JJ cord-005453-4057qib7 6002 2 tuning tuning NN cord-005453-4057qib7 6002 3 of of IN cord-005453-4057qib7 6002 4 early early JJ cord-005453-4057qib7 6002 5 tacrolimus tacrolimus NN cord-005453-4057qib7 6002 6 concentration concentration NN cord-005453-4057qib7 6002 7 with with IN cord-005453-4057qib7 6002 8 narrow narrow JJ cord-005453-4057qib7 6002 9 range range NN cord-005453-4057qib7 6002 10 of of IN cord-005453-4057qib7 6002 11 SD sd NN cord-005453-4057qib7 6002 12 reduces reduce VBZ cord-005453-4057qib7 6002 13 the the DT cord-005453-4057qib7 6002 14 risk risk NN cord-005453-4057qib7 6002 15 of of IN cord-005453-4057qib7 6002 16 aGVHD aGVHD NNP cord-005453-4057qib7 6002 17 , , , cord-005453-4057qib7 6002 18 resulting result VBG cord-005453-4057qib7 6002 19 in in IN cord-005453-4057qib7 6002 20 improvement improvement NN cord-005453-4057qib7 6002 21 of of IN cord-005453-4057qib7 6002 22 the the DT cord-005453-4057qib7 6002 23 overall overall JJ cord-005453-4057qib7 6002 24 survival survival NN cord-005453-4057qib7 6002 25 after after IN cord-005453-4057qib7 6002 26 allo allo NN cord-005453-4057qib7 6002 27 - - HYPH cord-005453-4057qib7 6002 28 HSCT HSCT NNP cord-005453-4057qib7 6002 29 . . . cord-005453-4057qib7 6003 1 Disclosure disclosure NN cord-005453-4057qib7 6003 2 : : : cord-005453-4057qib7 6003 3 Nothing nothing NN cord-005453-4057qib7 6003 4 to to TO cord-005453-4057qib7 6003 5 declair declair VB cord-005453-4057qib7 6003 6 P274 P274 NNP cord-005453-4057qib7 6003 7 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 6003 8 treatment treatment NN cord-005453-4057qib7 6003 9 for for IN cord-005453-4057qib7 6003 10 steroid steroid NN cord-005453-4057qib7 6003 11 - - HYPH cord-005453-4057qib7 6003 12 refractory refractory JJ cord-005453-4057qib7 6003 13 graftversus graftversus NN cord-005453-4057qib7 6003 14 - - HYPH cord-005453-4057qib7 6003 15 host host NN cord-005453-4057qib7 6003 16 disease disease NN cord-005453-4057qib7 6003 17 Han Han NNP cord-005453-4057qib7 6003 18 - - HYPH cord-005453-4057qib7 6003 19 Seung Seung NNP cord-005453-4057qib7 6003 20 Park Park NNP cord-005453-4057qib7 6003 21 1 1 CD cord-005453-4057qib7 6003 22 , , , cord-005453-4057qib7 6003 23 Je Je NNP cord-005453-4057qib7 6003 24 - - HYPH cord-005453-4057qib7 6003 25 Hwan Hwan NNP cord-005453-4057qib7 6003 26 Lee Lee NNP cord-005453-4057qib7 6003 27 1 1 CD cord-005453-4057qib7 6003 28 , , , cord-005453-4057qib7 6004 1 Jung Jung NNP cord-005453-4057qib7 6004 2 - - HYPH cord-005453-4057qib7 6004 3 Hee Hee NNP cord-005453-4057qib7 6004 4 Lee Lee NNP cord-005453-4057qib7 6004 5 1 1 CD cord-005453-4057qib7 6004 6 , , , cord-005453-4057qib7 6004 7 Eun Eun NNP cord-005453-4057qib7 6004 8 - - HYPH cord-005453-4057qib7 6004 9 Ji Ji NNP cord-005453-4057qib7 6004 10 Choi Choi NNP cord-005453-4057qib7 6004 11 1 1 CD cord-005453-4057qib7 6004 12 , , , cord-005453-4057qib7 6004 13 Miee Miee NNP cord-005453-4057qib7 6004 14 Seol Seol NNP cord-005453-4057qib7 6004 15 1 1 CD cord-005453-4057qib7 6004 16 , , , cord-005453-4057qib7 6004 17 Young Young NNP cord-005453-4057qib7 6004 18 - - HYPH cord-005453-4057qib7 6004 19 Shin Shin NNP cord-005453-4057qib7 6004 20 Lee Lee NNP cord-005453-4057qib7 6004 21 1 1 CD cord-005453-4057qib7 6004 22 , , , cord-005453-4057qib7 6004 23 Young Young NNP cord-005453-4057qib7 6004 24 - - HYPH cord-005453-4057qib7 6004 25 Ah Ah NNP cord-005453-4057qib7 6004 26 Kang Kang NNP cord-005453-4057qib7 6004 27 1 1 CD cord-005453-4057qib7 6004 28 , , , cord-005453-4057qib7 6004 29 Mijin Mijin NNP cord-005453-4057qib7 6004 30 Jeon Jeon NNP cord-005453-4057qib7 6004 31 1 1 CD cord-005453-4057qib7 6005 1 , , , cord-005453-4057qib7 6005 2 Kyoo Kyoo NNP cord-005453-4057qib7 6005 3 - - HYPH cord-005453-4057qib7 6005 4 Hyung Hyung NNP cord-005453-4057qib7 6005 5 Lee Lee NNP cord-005453-4057qib7 6005 6 1 1 CD cord-005453-4057qib7 6005 7 Background Background NNP cord-005453-4057qib7 6005 8 : : : cord-005453-4057qib7 6005 9 Steroid steroid JJ cord-005453-4057qib7 6005 10 - - HYPH cord-005453-4057qib7 6005 11 refractory refractory JJ cord-005453-4057qib7 6005 12 graft graft NN cord-005453-4057qib7 6005 13 versus versus IN cord-005453-4057qib7 6005 14 - - HYPH cord-005453-4057qib7 6005 15 host host NN cord-005453-4057qib7 6005 16 disease disease NN cord-005453-4057qib7 6005 17 ( ( -LRB- cord-005453-4057qib7 6005 18 GVHD GVHD NNP cord-005453-4057qib7 6005 19 ) ) -RRB- cord-005453-4057qib7 6005 20 is be VBZ cord-005453-4057qib7 6005 21 one one CD cord-005453-4057qib7 6005 22 of of IN cord-005453-4057qib7 6005 23 the the DT cord-005453-4057qib7 6005 24 most most RBS cord-005453-4057qib7 6005 25 lethal lethal JJ cord-005453-4057qib7 6005 26 complications complication NNS cord-005453-4057qib7 6005 27 after after IN cord-005453-4057qib7 6005 28 allogeneic allogeneic JJ cord-005453-4057qib7 6005 29 hematopoietic hematopoietic JJ cord-005453-4057qib7 6005 30 cell cell NN cord-005453-4057qib7 6005 31 transplantation transplantation NN cord-005453-4057qib7 6005 32 . . . cord-005453-4057qib7 6006 1 Recent recent JJ cord-005453-4057qib7 6006 2 studies study NNS cord-005453-4057qib7 6006 3 have have VBP cord-005453-4057qib7 6006 4 shown show VBN cord-005453-4057qib7 6006 5 that that IN cord-005453-4057qib7 6006 6 ruxolitinib ruxolitinib NN cord-005453-4057qib7 6006 7 , , , cord-005453-4057qib7 6006 8 a a DT cord-005453-4057qib7 6006 9 Janus Janus NNP cord-005453-4057qib7 6006 10 kinase kinase NN cord-005453-4057qib7 6006 11 1/2 1/2 CD cord-005453-4057qib7 6006 12 inhibitor inhibitor NN cord-005453-4057qib7 6006 13 , , , cord-005453-4057qib7 6006 14 is be VBZ cord-005453-4057qib7 6006 15 effective effective JJ cord-005453-4057qib7 6006 16 in in IN cord-005453-4057qib7 6006 17 patients patient NNS cord-005453-4057qib7 6006 18 suffering suffer VBG cord-005453-4057qib7 6006 19 from from IN cord-005453-4057qib7 6006 20 GVHD GVHD NNP cord-005453-4057qib7 6006 21 . . . cord-005453-4057qib7 6007 1 Here here RB cord-005453-4057qib7 6007 2 , , , cord-005453-4057qib7 6007 3 we -PRON- PRP cord-005453-4057qib7 6007 4 report report VBP cord-005453-4057qib7 6007 5 a a DT cord-005453-4057qib7 6007 6 retrospective retrospective JJ cord-005453-4057qib7 6007 7 result result NN cord-005453-4057qib7 6007 8 of of IN cord-005453-4057qib7 6007 9 ruxolitinib ruxolitinib JJ cord-005453-4057qib7 6007 10 treatment treatment NN cord-005453-4057qib7 6007 11 for for IN cord-005453-4057qib7 6007 12 steroid steroid NN cord-005453-4057qib7 6007 13 - - HYPH cord-005453-4057qib7 6007 14 refractory refractory JJ cord-005453-4057qib7 6007 15 GVHD GVHD NNP cord-005453-4057qib7 6007 16 . . . cord-005453-4057qib7 6008 1 Methods method NNS cord-005453-4057qib7 6008 2 : : : cord-005453-4057qib7 6009 1 All all DT cord-005453-4057qib7 6009 2 patients patient NNS cord-005453-4057qib7 6009 3 had have VBD cord-005453-4057qib7 6009 4 received receive VBN cord-005453-4057qib7 6009 5 cyclosporine cyclosporine NN cord-005453-4057qib7 6009 6 and and CC cord-005453-4057qib7 6009 7 a a DT cord-005453-4057qib7 6009 8 short short JJ cord-005453-4057qib7 6009 9 course course NN cord-005453-4057qib7 6009 10 of of IN cord-005453-4057qib7 6009 11 methotrexate methotrexate NNP cord-005453-4057qib7 6009 12 as as IN cord-005453-4057qib7 6009 13 GVHD GVHD NNP cord-005453-4057qib7 6009 14 prophylaxis prophylaxis NN cord-005453-4057qib7 6009 15 . . . cord-005453-4057qib7 6010 1 Antithymocyte Antithymocyte NNP cord-005453-4057qib7 6010 2 globulin globulin NN cord-005453-4057qib7 6010 3 was be VBD cord-005453-4057qib7 6010 4 added add VBN cord-005453-4057qib7 6010 5 for for IN cord-005453-4057qib7 6010 6 unrelated unrelated JJ cord-005453-4057qib7 6010 7 or or CC cord-005453-4057qib7 6010 8 mismatched mismatched JJ cord-005453-4057qib7 6010 9 familial familial JJ cord-005453-4057qib7 6010 10 donor donor NN cord-005453-4057qib7 6010 11 HCT hct NN cord-005453-4057qib7 6010 12 . . . cord-005453-4057qib7 6011 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 6011 2 5 5 CD cord-005453-4057qib7 6011 3 mg mg NN cord-005453-4057qib7 6011 4 twice twice RB cord-005453-4057qib7 6011 5 daily daily RB cord-005453-4057qib7 6011 6 was be VBD cord-005453-4057qib7 6011 7 added add VBN cord-005453-4057qib7 6011 8 to to IN cord-005453-4057qib7 6011 9 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6011 10 treatment treatment NN cord-005453-4057qib7 6011 11 in in IN cord-005453-4057qib7 6011 12 patients patient NNS cord-005453-4057qib7 6011 13 with with IN cord-005453-4057qib7 6011 14 steroid steroid JJ cord-005453-4057qib7 6011 15 - - HYPH cord-005453-4057qib7 6011 16 refractory refractory JJ cord-005453-4057qib7 6011 17 GVHD GVHD NNP cord-005453-4057qib7 6011 18 . . . cord-005453-4057qib7 6012 1 Results result NNS cord-005453-4057qib7 6012 2 : : : cord-005453-4057qib7 6013 1 A a DT cord-005453-4057qib7 6013 2 total total NN cord-005453-4057qib7 6013 3 of of IN cord-005453-4057qib7 6013 4 27 27 CD cord-005453-4057qib7 6013 5 patients patient NNS cord-005453-4057qib7 6013 6 with with IN cord-005453-4057qib7 6013 7 GVHD GVHD NNP cord-005453-4057qib7 6013 8 ( ( -LRB- cord-005453-4057qib7 6013 9 acute acute JJ cord-005453-4057qib7 6013 10 , , , cord-005453-4057qib7 6013 11 8 8 CD cord-005453-4057qib7 6013 12 , , , cord-005453-4057qib7 6013 13 including include VBG cord-005453-4057qib7 6013 14 3 3 CD cord-005453-4057qib7 6013 15 patients patient NNS cord-005453-4057qib7 6013 16 with with IN cord-005453-4057qib7 6013 17 donor donor NN cord-005453-4057qib7 6013 18 lymphocyte lymphocyte NN cord-005453-4057qib7 6013 19 infusion infusion NN cord-005453-4057qib7 6013 20 [ [ -LRB- cord-005453-4057qib7 6013 21 DLI]related dli]related XX cord-005453-4057qib7 6013 22 ; ; : cord-005453-4057qib7 6013 23 and and CC cord-005453-4057qib7 6013 24 chronic chronic NN cord-005453-4057qib7 6013 25 , , , cord-005453-4057qib7 6013 26 19 19 CD cord-005453-4057qib7 6013 27 ) ) -RRB- cord-005453-4057qib7 6013 28 were be VBD cord-005453-4057qib7 6013 29 included include VBN cord-005453-4057qib7 6013 30 in in IN cord-005453-4057qib7 6013 31 the the DT cord-005453-4057qib7 6013 32 analysis analysis NN cord-005453-4057qib7 6013 33 . . . cord-005453-4057qib7 6014 1 All all DT cord-005453-4057qib7 6014 2 patients patient NNS cord-005453-4057qib7 6014 3 had have VBD cord-005453-4057qib7 6014 4 grade grade NN cord-005453-4057qib7 6014 5 3/4 3/4 CD cord-005453-4057qib7 6014 6 acute acute JJ cord-005453-4057qib7 6014 7 GVHD GVHD NNP cord-005453-4057qib7 6014 8 or or CC cord-005453-4057qib7 6014 9 severe severe JJ cord-005453-4057qib7 6014 10 chronic chronic JJ cord-005453-4057qib7 6014 11 GVHD GVHD NNP cord-005453-4057qib7 6014 12 at at IN cord-005453-4057qib7 6014 13 the the DT cord-005453-4057qib7 6014 14 time time NN cord-005453-4057qib7 6014 15 of of IN cord-005453-4057qib7 6014 16 ruxolitinib ruxolitinib JJ cord-005453-4057qib7 6014 17 treatment treatment NN cord-005453-4057qib7 6014 18 . . . cord-005453-4057qib7 6015 1 Six six CD cord-005453-4057qib7 6015 2 ( ( -LRB- cord-005453-4057qib7 6015 3 75.0 75.0 CD cord-005453-4057qib7 6015 4 % % NN cord-005453-4057qib7 6015 5 ) ) -RRB- cord-005453-4057qib7 6015 6 of of IN cord-005453-4057qib7 6015 7 8 8 CD cord-005453-4057qib7 6015 8 patients patient NNS cord-005453-4057qib7 6015 9 with with IN cord-005453-4057qib7 6015 10 acute acute JJ cord-005453-4057qib7 6015 11 GVHD GVHD NNP cord-005453-4057qib7 6015 12 responded respond VBD cord-005453-4057qib7 6015 13 to to IN cord-005453-4057qib7 6015 14 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6015 15 , , , cord-005453-4057qib7 6015 16 including include VBG cord-005453-4057qib7 6015 17 3 3 CD cord-005453-4057qib7 6015 18 with with IN cord-005453-4057qib7 6015 19 complete complete JJ cord-005453-4057qib7 6015 20 response response NN cord-005453-4057qib7 6015 21 ( ( -LRB- cord-005453-4057qib7 6015 22 CR CR NNP cord-005453-4057qib7 6015 23 ) ) -RRB- cord-005453-4057qib7 6015 24 . . . cord-005453-4057qib7 6016 1 The the DT cord-005453-4057qib7 6016 2 median median JJ cord-005453-4057qib7 6016 3 time time NN cord-005453-4057qib7 6016 4 to to IN cord-005453-4057qib7 6016 5 response response NN cord-005453-4057qib7 6016 6 was be VBD cord-005453-4057qib7 6016 7 13.5 13.5 CD cord-005453-4057qib7 6016 8 days day NNS cord-005453-4057qib7 6016 9 ( ( -LRB- cord-005453-4057qib7 6016 10 range range NN cord-005453-4057qib7 6016 11 , , , cord-005453-4057qib7 6016 12 8 8 CD cord-005453-4057qib7 6016 13 - - SYM cord-005453-4057qib7 6016 14 25 25 CD cord-005453-4057qib7 6016 15 ) ) -RRB- cord-005453-4057qib7 6016 16 . . . cord-005453-4057qib7 6017 1 Nineteen nineteen CD cord-005453-4057qib7 6017 2 patients patient NNS cord-005453-4057qib7 6017 3 received receive VBD cord-005453-4057qib7 6017 4 ruxolitinib ruxolitinib NN cord-005453-4057qib7 6017 5 for for IN cord-005453-4057qib7 6017 6 severe severe JJ cord-005453-4057qib7 6017 7 chronic chronic JJ cord-005453-4057qib7 6017 8 GVHD GVHD NNP cord-005453-4057qib7 6017 9 , , , cord-005453-4057qib7 6017 10 with with IN cord-005453-4057qib7 6017 11 the the DT cord-005453-4057qib7 6017 12 median median NN cord-005453-4057qib7 6017 13 of of IN cord-005453-4057qib7 6017 14 3 3 CD cord-005453-4057qib7 6017 15 involved involved JJ cord-005453-4057qib7 6017 16 organs organ NNS cord-005453-4057qib7 6017 17 ( ( -LRB- cord-005453-4057qib7 6017 18 range range VBP cord-005453-4057qib7 6017 19 2 2 CD cord-005453-4057qib7 6017 20 - - SYM cord-005453-4057qib7 6017 21 5 5 CD cord-005453-4057qib7 6017 22 ) ) -RRB- cord-005453-4057qib7 6017 23 . . . cord-005453-4057qib7 6018 1 Fourteen fourteen CD cord-005453-4057qib7 6018 2 patients patient NNS cord-005453-4057qib7 6018 3 ( ( -LRB- cord-005453-4057qib7 6018 4 73.7 73.7 CD cord-005453-4057qib7 6018 5 % % NN cord-005453-4057qib7 6018 6 ) ) -RRB- cord-005453-4057qib7 6018 7 showed show VBD cord-005453-4057qib7 6018 8 response response NN cord-005453-4057qib7 6018 9 to to IN cord-005453-4057qib7 6018 10 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6018 11 , , , cord-005453-4057qib7 6018 12 including include VBG cord-005453-4057qib7 6018 13 4 4 CD cord-005453-4057qib7 6018 14 CRs cr NNS cord-005453-4057qib7 6018 15 . . . cord-005453-4057qib7 6019 1 The the DT cord-005453-4057qib7 6019 2 median median JJ cord-005453-4057qib7 6019 3 time time NN cord-005453-4057qib7 6019 4 to to IN cord-005453-4057qib7 6019 5 response response NN cord-005453-4057qib7 6019 6 was be VBD cord-005453-4057qib7 6019 7 24 24 CD cord-005453-4057qib7 6019 8 days day NNS cord-005453-4057qib7 6019 9 ( ( -LRB- cord-005453-4057qib7 6019 10 range range NN cord-005453-4057qib7 6019 11 , , , cord-005453-4057qib7 6019 12 12 12 CD cord-005453-4057qib7 6019 13 - - SYM cord-005453-4057qib7 6019 14 138 138 CD cord-005453-4057qib7 6019 15 ) ) -RRB- cord-005453-4057qib7 6019 16 . . . cord-005453-4057qib7 6020 1 Five five CD cord-005453-4057qib7 6020 2 responders responder NNS cord-005453-4057qib7 6020 3 discontinued discontinue VBD cord-005453-4057qib7 6020 4 ruxolitinib ruxolitinib NN cord-005453-4057qib7 6020 5 and and CC cord-005453-4057qib7 6020 6 9 9 CD cord-005453-4057qib7 6020 7 patients patient NNS cord-005453-4057qib7 6020 8 are be VBP cord-005453-4057qib7 6020 9 still still RB cord-005453-4057qib7 6020 10 on on IN cord-005453-4057qib7 6020 11 the the DT cord-005453-4057qib7 6020 12 agent agent NN cord-005453-4057qib7 6020 13 . . . cord-005453-4057qib7 6021 1 After after IN cord-005453-4057qib7 6021 2 a a DT cord-005453-4057qib7 6021 3 median median JJ cord-005453-4057qib7 6021 4 follow follow NN cord-005453-4057qib7 6021 5 - - HYPH cord-005453-4057qib7 6021 6 up up NN cord-005453-4057qib7 6021 7 duration duration NN cord-005453-4057qib7 6021 8 of of IN cord-005453-4057qib7 6021 9 8.7 8.7 CD cord-005453-4057qib7 6021 10 months month NNS cord-005453-4057qib7 6021 11 , , , cord-005453-4057qib7 6021 12 5 5 CD cord-005453-4057qib7 6021 13 died die VBD cord-005453-4057qib7 6021 14 ( ( -LRB- cord-005453-4057qib7 6021 15 2 2 CD cord-005453-4057qib7 6021 16 from from IN cord-005453-4057qib7 6021 17 relapse relapse NN cord-005453-4057qib7 6021 18 of of IN cord-005453-4057qib7 6021 19 disease disease NN cord-005453-4057qib7 6021 20 , , , cord-005453-4057qib7 6021 21 3 3 CD cord-005453-4057qib7 6021 22 from from IN cord-005453-4057qib7 6021 23 infection infection NN cord-005453-4057qib7 6021 24 ) ) -RRB- cord-005453-4057qib7 6021 25 . . . cord-005453-4057qib7 6022 1 The the DT cord-005453-4057qib7 6022 2 1-year 1-year CD cord-005453-4057qib7 6022 3 survival survival NN cord-005453-4057qib7 6022 4 probability probability NN cord-005453-4057qib7 6022 5 was be VBD cord-005453-4057qib7 6022 6 70.1 70.1 CD cord-005453-4057qib7 6022 7 % % NN cord-005453-4057qib7 6022 8 . . . cord-005453-4057qib7 6023 1 Eleven eleven CD cord-005453-4057qib7 6023 2 of of IN cord-005453-4057qib7 6023 3 20 20 CD cord-005453-4057qib7 6023 4 responders responder NNS cord-005453-4057qib7 6023 5 discontinued discontinue VBD cord-005453-4057qib7 6023 6 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6023 7 . . . cord-005453-4057qib7 6024 1 GVHD GVHD NNP cord-005453-4057qib7 6024 2 relapsed relapse VBD cord-005453-4057qib7 6024 3 in in IN cord-005453-4057qib7 6024 4 3 3 CD cord-005453-4057qib7 6024 5 of of IN cord-005453-4057qib7 6024 6 11 11 CD cord-005453-4057qib7 6024 7 patients patient NNS cord-005453-4057qib7 6024 8 at at IN cord-005453-4057qib7 6024 9 14 14 CD cord-005453-4057qib7 6024 10 , , , cord-005453-4057qib7 6024 11 35 35 CD cord-005453-4057qib7 6024 12 , , , cord-005453-4057qib7 6024 13 and and CC cord-005453-4057qib7 6024 14 149 149 CD cord-005453-4057qib7 6024 15 days day NNS cord-005453-4057qib7 6024 16 after after IN cord-005453-4057qib7 6024 17 ruxolitinib ruxolitinib JJ cord-005453-4057qib7 6024 18 discontinuation discontinuation NN cord-005453-4057qib7 6024 19 . . . cord-005453-4057qib7 6025 1 Thrombocytopenia Thrombocytopenia NNP cord-005453-4057qib7 6025 2 ( ( -LRB- cord-005453-4057qib7 6025 3 12/27 12/27 CD cord-005453-4057qib7 6025 4 , , , cord-005453-4057qib7 6025 5 Grade3/4 Grade3/4 NNP cord-005453-4057qib7 6025 6 ; ; : cord-005453-4057qib7 6025 7 4 4 LS cord-005453-4057qib7 6025 8 ) ) -RRB- cord-005453-4057qib7 6025 9 was be VBD cord-005453-4057qib7 6025 10 the the DT cord-005453-4057qib7 6025 11 most most RBS cord-005453-4057qib7 6025 12 common common JJ cord-005453-4057qib7 6025 13 adverse adverse JJ cord-005453-4057qib7 6025 14 event event NN cord-005453-4057qib7 6025 15 of of IN cord-005453-4057qib7 6025 16 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6025 17 . . . cord-005453-4057qib7 6026 1 During during IN cord-005453-4057qib7 6026 2 treatment treatment NN cord-005453-4057qib7 6026 3 , , , cord-005453-4057qib7 6026 4 4 4 CD cord-005453-4057qib7 6026 5 with with IN cord-005453-4057qib7 6026 6 grade grade NN cord-005453-4057qib7 6026 7 3/4 3/4 CD cord-005453-4057qib7 6026 8 infectious infectious JJ cord-005453-4057qib7 6026 9 adverse adverse JJ cord-005453-4057qib7 6026 10 events event NNS cord-005453-4057qib7 6026 11 occurred occur VBD cord-005453-4057qib7 6026 12 ; ; : cord-005453-4057qib7 6026 13 2 2 CD cord-005453-4057qib7 6026 14 pneumonias pneumonia NNS cord-005453-4057qib7 6026 15 , , , cord-005453-4057qib7 6026 16 1 1 CD cord-005453-4057qib7 6026 17 brain brain NN cord-005453-4057qib7 6026 18 abscess abscess NN cord-005453-4057qib7 6026 19 , , , cord-005453-4057qib7 6026 20 and and CC cord-005453-4057qib7 6026 21 1 1 CD cord-005453-4057qib7 6026 22 liver liver NN cord-005453-4057qib7 6026 23 abscess abscess NN cord-005453-4057qib7 6026 24 . . . cord-005453-4057qib7 6027 1 Conclusions conclusion NNS cord-005453-4057qib7 6027 2 : : : cord-005453-4057qib7 6028 1 Ruxolitinib ruxolitinib JJ cord-005453-4057qib7 6028 2 treatment treatment NN cord-005453-4057qib7 6028 3 seems seem VBZ cord-005453-4057qib7 6028 4 to to TO cord-005453-4057qib7 6028 5 be be VB cord-005453-4057qib7 6028 6 effective effective JJ cord-005453-4057qib7 6028 7 for for IN cord-005453-4057qib7 6028 8 the the DT cord-005453-4057qib7 6028 9 treatment treatment NN cord-005453-4057qib7 6028 10 of of IN cord-005453-4057qib7 6028 11 steroid steroid NN cord-005453-4057qib7 6028 12 - - HYPH cord-005453-4057qib7 6028 13 refractory refractory JJ cord-005453-4057qib7 6028 14 GVHD GVHD NNP cord-005453-4057qib7 6028 15 including include VBG cord-005453-4057qib7 6028 16 long long RB cord-005453-4057qib7 6028 17 - - HYPH cord-005453-4057qib7 6028 18 standing stand VBG cord-005453-4057qib7 6028 19 chronic chronic JJ cord-005453-4057qib7 6028 20 GVHD GVHD NNP cord-005453-4057qib7 6028 21 . . . cord-005453-4057qib7 6029 1 The the DT cord-005453-4057qib7 6029 2 agent agent NN cord-005453-4057qib7 6029 3 was be VBD cord-005453-4057qib7 6029 4 well well RB cord-005453-4057qib7 6029 5 tolerated tolerate VBN cord-005453-4057qib7 6029 6 and and CC cord-005453-4057qib7 6029 7 relatively relatively RB cord-005453-4057qib7 6029 8 safe safe JJ cord-005453-4057qib7 6029 9 . . . cord-005453-4057qib7 6030 1 Disclosure disclosure NN cord-005453-4057qib7 6030 2 : : : cord-005453-4057qib7 6030 3 Nothing nothing NN cord-005453-4057qib7 6030 4 to to TO cord-005453-4057qib7 6030 5 declare declare VB cord-005453-4057qib7 6030 6 . . . cord-005453-4057qib7 6031 1 IL6-receptor IL6-receptor NNP cord-005453-4057qib7 6031 2 antibody antibody NNP cord-005453-4057qib7 6031 3 tocilizumab tocilizumab NNP cord-005453-4057qib7 6031 4 as as IN cord-005453-4057qib7 6031 5 salvage salvage NN cord-005453-4057qib7 6031 6 therapy therapy NN cord-005453-4057qib7 6031 7 in in IN cord-005453-4057qib7 6031 8 the the DT cord-005453-4057qib7 6031 9 treatment treatment NN cord-005453-4057qib7 6031 10 of of IN cord-005453-4057qib7 6031 11 severe severe JJ cord-005453-4057qib7 6031 12 chronic chronic JJ cord-005453-4057qib7 6031 13 gvhd gvhd NN cord-005453-4057qib7 6031 14 after after IN cord-005453-4057qib7 6031 15 stem stem NN cord-005453-4057qib7 6031 16 cell cell NN cord-005453-4057qib7 6031 17 transplantation transplantation NN cord-005453-4057qib7 6031 18 : : : cord-005453-4057qib7 6032 1 A a DT cord-005453-4057qib7 6032 2 retrospective retrospective JJ cord-005453-4057qib7 6032 3 analysis analysis NN cord-005453-4057qib7 6033 1 Background background NN cord-005453-4057qib7 6033 2 : : : cord-005453-4057qib7 6034 1 Severe severe JJ cord-005453-4057qib7 6034 2 chronic chronic JJ cord-005453-4057qib7 6034 3 graft graft NN cord-005453-4057qib7 6034 4 - - HYPH cord-005453-4057qib7 6034 5 versus versus IN cord-005453-4057qib7 6034 6 - - HYPH cord-005453-4057qib7 6034 7 host host NN cord-005453-4057qib7 6034 8 disease disease NN cord-005453-4057qib7 6034 9 ( ( -LRB- cord-005453-4057qib7 6034 10 cGvHD cGvHD NNP cord-005453-4057qib7 6034 11 ) ) -RRB- cord-005453-4057qib7 6034 12 remains remain VBZ cord-005453-4057qib7 6034 13 the the DT cord-005453-4057qib7 6034 14 most most RBS cord-005453-4057qib7 6034 15 relevant relevant JJ cord-005453-4057qib7 6034 16 factor factor NN cord-005453-4057qib7 6034 17 affecting affect VBG cord-005453-4057qib7 6034 18 survival survival NN cord-005453-4057qib7 6034 19 and and CC cord-005453-4057qib7 6034 20 long long JJ cord-005453-4057qib7 6034 21 - - HYPH cord-005453-4057qib7 6034 22 term term NN cord-005453-4057qib7 6034 23 quality quality NN cord-005453-4057qib7 6034 24 of of IN cord-005453-4057qib7 6034 25 life life NN cord-005453-4057qib7 6034 26 after after IN cord-005453-4057qib7 6034 27 allogeneic allogeneic JJ cord-005453-4057qib7 6034 28 hematopoietic hematopoietic JJ cord-005453-4057qib7 6034 29 stem stem NN cord-005453-4057qib7 6034 30 cell cell NN cord-005453-4057qib7 6034 31 transplantation transplantation NN cord-005453-4057qib7 6034 32 ( ( -LRB- cord-005453-4057qib7 6034 33 HCT HCT NNP cord-005453-4057qib7 6034 34 ) ) -RRB- cord-005453-4057qib7 6034 35 . . . cord-005453-4057qib7 6035 1 Besides besides IN cord-005453-4057qib7 6035 2 corticosteroids corticosteroid NNS cord-005453-4057qib7 6035 3 there there EX cord-005453-4057qib7 6035 4 is be VBZ cord-005453-4057qib7 6035 5 no no DT cord-005453-4057qib7 6035 6 established establish VBN cord-005453-4057qib7 6035 7 therapy therapy NN cord-005453-4057qib7 6035 8 for for IN cord-005453-4057qib7 6035 9 cGvHD cGvHD NNP cord-005453-4057qib7 6035 10 and and CC cord-005453-4057qib7 6035 11 many many JJ cord-005453-4057qib7 6035 12 of of IN cord-005453-4057qib7 6035 13 the the DT cord-005453-4057qib7 6035 14 used use VBN cord-005453-4057qib7 6035 15 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6035 16 agents agent NNS cord-005453-4057qib7 6035 17 may may MD cord-005453-4057qib7 6035 18 lead lead VB cord-005453-4057qib7 6035 19 to to IN cord-005453-4057qib7 6035 20 significant significant JJ cord-005453-4057qib7 6035 21 toxicity toxicity NN cord-005453-4057qib7 6035 22 incl incl NNS cord-005453-4057qib7 6035 23 . . . cord-005453-4057qib7 6036 1 infectious infectious JJ cord-005453-4057qib7 6036 2 complications complication NNS cord-005453-4057qib7 6036 3 . . . cord-005453-4057qib7 6037 1 Tocilizumab Tocilizumab NNP cord-005453-4057qib7 6037 2 ( ( -LRB- cord-005453-4057qib7 6037 3 an an DT cord-005453-4057qib7 6037 4 IL6-receptor il6-receptor NN cord-005453-4057qib7 6037 5 antibody antibody NN cord-005453-4057qib7 6037 6 ) ) -RRB- cord-005453-4057qib7 6037 7 has have VBZ cord-005453-4057qib7 6037 8 shown show VBN cord-005453-4057qib7 6037 9 efficacy efficacy NN cord-005453-4057qib7 6037 10 in in IN cord-005453-4057qib7 6037 11 acute acute JJ cord-005453-4057qib7 6037 12 GvHD gvhd NN cord-005453-4057qib7 6037 13 and and CC cord-005453-4057qib7 6037 14 cGvHD cgvhd NN cord-005453-4057qib7 6037 15 . . . cord-005453-4057qib7 6038 1 We -PRON- PRP cord-005453-4057qib7 6038 2 retrospectively retrospectively RB cord-005453-4057qib7 6038 3 analyzed analyze VBD cord-005453-4057qib7 6038 4 the the DT cord-005453-4057qib7 6038 5 efficacy efficacy NN cord-005453-4057qib7 6038 6 and and CC cord-005453-4057qib7 6038 7 safety safety NN cord-005453-4057qib7 6038 8 of of IN cord-005453-4057qib7 6038 9 patients patient NNS cord-005453-4057qib7 6038 10 having have VBG cord-005453-4057qib7 6038 11 received receive VBN cord-005453-4057qib7 6038 12 tocilizumab tocilizumab NN cord-005453-4057qib7 6038 13 for for IN cord-005453-4057qib7 6038 14 treatment treatment NN cord-005453-4057qib7 6038 15 of of IN cord-005453-4057qib7 6038 16 advanced advanced JJ cord-005453-4057qib7 6038 17 cGvHD cgvhd NN cord-005453-4057qib7 6038 18 at at IN cord-005453-4057qib7 6038 19 our -PRON- PRP$ cord-005453-4057qib7 6038 20 center center NN cord-005453-4057qib7 6038 21 between between IN cord-005453-4057qib7 6038 22 the the DT cord-005453-4057qib7 6038 23 years year NNS cord-005453-4057qib7 6038 24 2015 2015 CD cord-005453-4057qib7 6038 25 and and CC cord-005453-4057qib7 6038 26 2018 2018 CD cord-005453-4057qib7 6038 27 . . . cord-005453-4057qib7 6039 1 Methods method NNS cord-005453-4057qib7 6039 2 : : : cord-005453-4057qib7 6039 3 9 9 CD cord-005453-4057qib7 6039 4 patients patient NNS cord-005453-4057qib7 6039 5 with with IN cord-005453-4057qib7 6039 6 severe severe JJ cord-005453-4057qib7 6039 7 steroid steroid NN cord-005453-4057qib7 6039 8 refractory refractory JJ cord-005453-4057qib7 6039 9 cGvHD cgvhd NN cord-005453-4057qib7 6039 10 and and CC cord-005453-4057qib7 6039 11 a a DT cord-005453-4057qib7 6039 12 median median JJ cord-005453-4057qib7 6039 13 age age NN cord-005453-4057qib7 6039 14 of of IN cord-005453-4057qib7 6039 15 50 50 CD cord-005453-4057qib7 6039 16 years year NNS cord-005453-4057qib7 6040 1 ( ( -LRB- cord-005453-4057qib7 6040 2 range range NN cord-005453-4057qib7 6040 3 : : : cord-005453-4057qib7 6040 4 21 21 CD cord-005453-4057qib7 6040 5 - - SYM cord-005453-4057qib7 6040 6 62 62 CD cord-005453-4057qib7 6040 7 yrs yrs NN cord-005453-4057qib7 6040 8 ) ) -RRB- cord-005453-4057qib7 6040 9 having have VBG cord-005453-4057qib7 6040 10 received receive VBN cord-005453-4057qib7 6040 11 at at RB cord-005453-4057qib7 6040 12 least least RBS cord-005453-4057qib7 6040 13 two two CD cord-005453-4057qib7 6040 14 prior prior JJ cord-005453-4057qib7 6040 15 lines line NNS cord-005453-4057qib7 6040 16 of of IN cord-005453-4057qib7 6040 17 therapy therapy NN cord-005453-4057qib7 6040 18 for for IN cord-005453-4057qib7 6040 19 cGvHD cGvHD NNP cord-005453-4057qib7 6040 20 ( ( -LRB- cord-005453-4057qib7 6040 21 range range NN cord-005453-4057qib7 6040 22 : : : cord-005453-4057qib7 6040 23 2 2 CD cord-005453-4057qib7 6040 24 - - SYM cord-005453-4057qib7 6040 25 8 8 CD cord-005453-4057qib7 6040 26 regimens regimen NNS cord-005453-4057qib7 6040 27 ) ) -RRB- cord-005453-4057qib7 6040 28 were be VBD cord-005453-4057qib7 6040 29 treated treat VBN cord-005453-4057qib7 6040 30 with with IN cord-005453-4057qib7 6040 31 tocilizumab tocilizumab NNP cord-005453-4057qib7 6040 32 for for IN cord-005453-4057qib7 6040 33 at at RB cord-005453-4057qib7 6040 34 least least RBS cord-005453-4057qib7 6040 35 one one CD cord-005453-4057qib7 6040 36 cycle cycle NN cord-005453-4057qib7 6040 37 ( ( -LRB- cord-005453-4057qib7 6040 38 q4w q4w UH cord-005453-4057qib7 6040 39 , , , cord-005453-4057qib7 6040 40 dosage dosage NN cord-005453-4057qib7 6040 41 : : : cord-005453-4057qib7 6040 42 8 8 CD cord-005453-4057qib7 6040 43 mg mg NNP cord-005453-4057qib7 6040 44 / / SYM cord-005453-4057qib7 6040 45 kg kg NN cord-005453-4057qib7 6041 1 iv iv LS cord-005453-4057qib7 6041 2 , , , cord-005453-4057qib7 6041 3 maximum maximum NNP cord-005453-4057qib7 6041 4 : : : cord-005453-4057qib7 6041 5 800 800 CD cord-005453-4057qib7 6041 6 mg mg NNP cord-005453-4057qib7 6041 7 ) ) -RRB- cord-005453-4057qib7 6041 8 with with IN cord-005453-4057qib7 6041 9 a a DT cord-005453-4057qib7 6041 10 median median JJ cord-005453-4057qib7 6041 11 number number NN cord-005453-4057qib7 6041 12 of of IN cord-005453-4057qib7 6041 13 4 4 CD cord-005453-4057qib7 6041 14 cycles cycle NNS cord-005453-4057qib7 6041 15 ( ( -LRB- cord-005453-4057qib7 6041 16 range range NN cord-005453-4057qib7 6041 17 : : : cord-005453-4057qib7 6041 18 . . . cord-005453-4057qib7 6042 1 NIH NIH NNP cord-005453-4057qib7 6042 2 consensus consensus NN cord-005453-4057qib7 6042 3 criteria criterion NNS cord-005453-4057qib7 6042 4 grading grade VBG cord-005453-4057qib7 6042 5 for for IN cord-005453-4057qib7 6042 6 cGvHD cgvhd NN cord-005453-4057qib7 6042 7 and and CC cord-005453-4057qib7 6043 1 the the DT cord-005453-4057qib7 6043 2 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6043 3 regimen regimen NN cord-005453-4057qib7 6043 4 were be VBD cord-005453-4057qib7 6043 5 noted note VBN cord-005453-4057qib7 6043 6 at at IN cord-005453-4057qib7 6043 7 the the DT cord-005453-4057qib7 6043 8 time time NN cord-005453-4057qib7 6043 9 of of IN cord-005453-4057qib7 6043 10 the the DT cord-005453-4057qib7 6043 11 first first JJ cord-005453-4057qib7 6043 12 tocilizumab tocilizumab NNP cord-005453-4057qib7 6043 13 administration administration NN cord-005453-4057qib7 6043 14 and and CC cord-005453-4057qib7 6043 15 after after IN cord-005453-4057qib7 6043 16 3 3 CD cord-005453-4057qib7 6043 17 , , , cord-005453-4057qib7 6043 18 6 6 CD cord-005453-4057qib7 6043 19 and and CC cord-005453-4057qib7 6043 20 12 12 CD cord-005453-4057qib7 6043 21 months month NNS cord-005453-4057qib7 6043 22 of of IN cord-005453-4057qib7 6043 23 therapy therapy NN cord-005453-4057qib7 6043 24 . . . cord-005453-4057qib7 6044 1 All all DT cord-005453-4057qib7 6044 2 patients patient NNS cord-005453-4057qib7 6044 3 received receive VBD cord-005453-4057qib7 6044 4 additional additional JJ cord-005453-4057qib7 6044 5 concomitant concomitant JJ cord-005453-4057qib7 6044 6 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6044 7 agents agent NNS cord-005453-4057qib7 6044 8 already already RB cord-005453-4057qib7 6044 9 given give VBN cord-005453-4057qib7 6044 10 at at IN cord-005453-4057qib7 6044 11 least least JJS cord-005453-4057qib7 6044 12 4 4 CD cord-005453-4057qib7 6044 13 weeks week NNS cord-005453-4057qib7 6044 14 without without IN cord-005453-4057qib7 6044 15 response response NN cord-005453-4057qib7 6044 16 before before IN cord-005453-4057qib7 6044 17 start start NN cord-005453-4057qib7 6044 18 of of IN cord-005453-4057qib7 6044 19 tocilizumab tocilizumab NN cord-005453-4057qib7 6044 20 . . . cord-005453-4057qib7 6045 1 No no DT cord-005453-4057qib7 6045 2 new new JJ cord-005453-4057qib7 6045 3 immunosuppression immunosuppression NN cord-005453-4057qib7 6045 4 ( ( -LRB- cord-005453-4057qib7 6045 5 IS is NN cord-005453-4057qib7 6045 6 ) ) -RRB- cord-005453-4057qib7 6045 7 was be VBD cord-005453-4057qib7 6045 8 added add VBN cord-005453-4057qib7 6045 9 in in IN cord-005453-4057qib7 6045 10 parallel parallel NN cord-005453-4057qib7 6045 11 to to IN cord-005453-4057qib7 6045 12 tocilizumab tocilizumab NN cord-005453-4057qib7 6045 13 and and CC cord-005453-4057qib7 6045 14 response response NN cord-005453-4057qib7 6045 15 assessment assessment NN cord-005453-4057qib7 6045 16 was be VBD cord-005453-4057qib7 6045 17 stopped stop VBN cord-005453-4057qib7 6045 18 at at IN cord-005453-4057qib7 6045 19 start start NN cord-005453-4057qib7 6045 20 of of IN cord-005453-4057qib7 6045 21 any any DT cord-005453-4057qib7 6045 22 additional additional JJ cord-005453-4057qib7 6045 23 new new JJ cord-005453-4057qib7 6045 24 IS is NN cord-005453-4057qib7 6045 25 . . . cord-005453-4057qib7 6046 1 All all DT cord-005453-4057qib7 6046 2 patients patient NNS cord-005453-4057qib7 6046 3 had have VBD cord-005453-4057qib7 6046 4 received receive VBN cord-005453-4057qib7 6046 5 peripheral peripheral JJ cord-005453-4057qib7 6046 6 stem stem NN cord-005453-4057qib7 6046 7 cell cell NN cord-005453-4057qib7 6046 8 allografts allograft NNS cord-005453-4057qib7 6046 9 . . . cord-005453-4057qib7 6047 1 GvHD GvHD NNP cord-005453-4057qib7 6047 2 prophylaxis prophylaxis NN cord-005453-4057qib7 6047 3 consisted consist VBD cord-005453-4057qib7 6047 4 of of IN cord-005453-4057qib7 6047 5 a a DT cord-005453-4057qib7 6047 6 calcineurin calcineurin JJ cord-005453-4057qib7 6047 7 inhibitor inhibitor NN cord-005453-4057qib7 6047 8 in in IN cord-005453-4057qib7 6047 9 combination combination NN cord-005453-4057qib7 6047 10 with with IN cord-005453-4057qib7 6047 11 methotrexate methotrexate NNP cord-005453-4057qib7 6047 12 or or CC cord-005453-4057qib7 6047 13 mycophenolate mycophenolate NNP cord-005453-4057qib7 6047 14 and and CC cord-005453-4057qib7 6047 15 in in IN cord-005453-4057qib7 6047 16 case case NN cord-005453-4057qib7 6047 17 of of IN cord-005453-4057qib7 6047 18 unrelated unrelated JJ cord-005453-4057qib7 6047 19 donors donor NNS cord-005453-4057qib7 6047 20 ATG ATG NNP cord-005453-4057qib7 6047 21 was be VBD cord-005453-4057qib7 6047 22 added add VBN cord-005453-4057qib7 6047 23 . . . cord-005453-4057qib7 6048 1 8/9 8/9 CD cord-005453-4057qib7 6048 2 patients patient NNS cord-005453-4057qib7 6048 3 had have VBD cord-005453-4057qib7 6048 4 quiescent quiescent JJ cord-005453-4057qib7 6048 5 onset onset NN cord-005453-4057qib7 6048 6 of of IN cord-005453-4057qib7 6048 7 cGvHD cgvhd NN cord-005453-4057qib7 6048 8 , , , cord-005453-4057qib7 6048 9 one one CD cord-005453-4057qib7 6048 10 patient patient NN cord-005453-4057qib7 6048 11 developed develop VBN cord-005453-4057qib7 6048 12 de de IN cord-005453-4057qib7 6048 13 novo novo NNP cord-005453-4057qib7 6048 14 cGvHD cGvHD NNP cord-005453-4057qib7 6048 15 . . . cord-005453-4057qib7 6049 1 The the DT cord-005453-4057qib7 6049 2 median median JJ cord-005453-4057qib7 6049 3 number number NN cord-005453-4057qib7 6049 4 of of IN cord-005453-4057qib7 6049 5 days day NNS cord-005453-4057qib7 6049 6 between between IN cord-005453-4057qib7 6049 7 HCT hct NN cord-005453-4057qib7 6049 8 and and CC cord-005453-4057qib7 6049 9 onset onset NN cord-005453-4057qib7 6049 10 of of IN cord-005453-4057qib7 6049 11 cGvHD cgvhd NN cord-005453-4057qib7 6049 12 was be VBD cord-005453-4057qib7 6049 13 215 215 CD cord-005453-4057qib7 6049 14 ( ( -LRB- cord-005453-4057qib7 6049 15 89 89 CD cord-005453-4057qib7 6049 16 - - SYM cord-005453-4057qib7 6049 17 545 545 CD cord-005453-4057qib7 6049 18 ) ) -RRB- cord-005453-4057qib7 6049 19 . . . cord-005453-4057qib7 6050 1 The the DT cord-005453-4057qib7 6050 2 median median JJ cord-005453-4057qib7 6050 3 number number NN cord-005453-4057qib7 6050 4 of of IN cord-005453-4057qib7 6050 5 days day NNS cord-005453-4057qib7 6050 6 between between IN cord-005453-4057qib7 6050 7 HCT hct NN cord-005453-4057qib7 6050 8 and and CC cord-005453-4057qib7 6050 9 initiation initiation NN cord-005453-4057qib7 6050 10 of of IN cord-005453-4057qib7 6050 11 tocilizumab tocilizumab NNP cord-005453-4057qib7 6050 12 therapy therapy NN cord-005453-4057qib7 6050 13 was be VBD cord-005453-4057qib7 6050 14 1033 1033 CD cord-005453-4057qib7 6050 15 ( ( -LRB- cord-005453-4057qib7 6050 16 510 510 CD cord-005453-4057qib7 6050 17 - - HYPH cord-005453-4057qib7 6050 18 1749 1749 CD cord-005453-4057qib7 6050 19 ) ) -RRB- cord-005453-4057qib7 6050 20 days day NNS cord-005453-4057qib7 6050 21 . . . cord-005453-4057qib7 6051 1 At at IN cord-005453-4057qib7 6051 2 cGvHD cGvHD NNP cord-005453-4057qib7 6051 3 onset onset NN cord-005453-4057qib7 6051 4 , , , cord-005453-4057qib7 6051 5 7/9 7/9 CD cord-005453-4057qib7 6051 6 patients patient NNS cord-005453-4057qib7 6051 7 had have VBD cord-005453-4057qib7 6051 8 mild mild JJ cord-005453-4057qib7 6051 9 cGvHD cgvhd NN cord-005453-4057qib7 6051 10 and and CC cord-005453-4057qib7 6051 11 2/9 2/9 CD cord-005453-4057qib7 6051 12 patients patient NNS cord-005453-4057qib7 6051 13 had have VBD cord-005453-4057qib7 6051 14 moderate moderate JJ cord-005453-4057qib7 6051 15 cGvHD cgvhd NN cord-005453-4057qib7 6051 16 . . . cord-005453-4057qib7 6052 1 The the DT cord-005453-4057qib7 6052 2 thrombocyte thrombocyte NN cord-005453-4057qib7 6052 3 count count NN cord-005453-4057qib7 6052 4 was be VBD cord-005453-4057qib7 6052 5 < < NNP cord-005453-4057qib7 6052 6 100 100 CD cord-005453-4057qib7 6052 7 / / SYM cord-005453-4057qib7 6052 8 nl nl NNP cord-005453-4057qib7 6052 9 in in IN cord-005453-4057qib7 6052 10 5/9 5/9 CD cord-005453-4057qib7 6052 11 patients patient NNS cord-005453-4057qib7 6052 12 . . . cord-005453-4057qib7 6053 1 Organs organ NNS cord-005453-4057qib7 6053 2 involved involve VBN cord-005453-4057qib7 6053 3 at at IN cord-005453-4057qib7 6053 4 initiation initiation NN cord-005453-4057qib7 6053 5 of of IN cord-005453-4057qib7 6053 6 tocilizumab tocilizumab NNP cord-005453-4057qib7 6053 7 therapy therapy NN cord-005453-4057qib7 6053 8 were be VBD cord-005453-4057qib7 6053 9 skin skin NN cord-005453-4057qib7 6053 10 ( ( -LRB- cord-005453-4057qib7 6053 11 100 100 CD cord-005453-4057qib7 6053 12 % % NN cord-005453-4057qib7 6053 13 , , , cord-005453-4057qib7 6053 14 all all DT cord-005453-4057qib7 6053 15 grade grade NN cord-005453-4057qib7 6053 16 3 3 CD cord-005453-4057qib7 6053 17 ) ) -RRB- cord-005453-4057qib7 6053 18 , , , cord-005453-4057qib7 6053 19 eyes eye NNS cord-005453-4057qib7 6053 20 ( ( -LRB- cord-005453-4057qib7 6053 21 78 78 CD cord-005453-4057qib7 6053 22 % % NN cord-005453-4057qib7 6053 23 ) ) -RRB- cord-005453-4057qib7 6053 24 , , , cord-005453-4057qib7 6053 25 mouth mouth NN cord-005453-4057qib7 6053 26 ( ( -LRB- cord-005453-4057qib7 6053 27 67 67 CD cord-005453-4057qib7 6053 28 % % NN cord-005453-4057qib7 6053 29 ) ) -RRB- cord-005453-4057qib7 6053 30 , , , cord-005453-4057qib7 6053 31 fascia fascia NN cord-005453-4057qib7 6053 32 ( ( -LRB- cord-005453-4057qib7 6053 33 67 67 CD cord-005453-4057qib7 6053 34 % % NN cord-005453-4057qib7 6053 35 ) ) -RRB- cord-005453-4057qib7 6053 36 , , , cord-005453-4057qib7 6053 37 lungs lung NNS cord-005453-4057qib7 6053 38 ( ( -LRB- cord-005453-4057qib7 6053 39 44 44 CD cord-005453-4057qib7 6053 40 % % NN cord-005453-4057qib7 6053 41 ) ) -RRB- cord-005453-4057qib7 6053 42 and and CC cord-005453-4057qib7 6053 43 genitals genital NNS cord-005453-4057qib7 6053 44 ( ( -LRB- cord-005453-4057qib7 6053 45 22 22 CD cord-005453-4057qib7 6053 46 % % NN cord-005453-4057qib7 6053 47 ) ) -RRB- cord-005453-4057qib7 6053 48 . . . cord-005453-4057qib7 6054 1 5/9 5/9 CD cord-005453-4057qib7 6054 2 patients patient NNS cord-005453-4057qib7 6054 3 are be VBP cord-005453-4057qib7 6054 4 still still RB cord-005453-4057qib7 6054 5 receiving receive VBG cord-005453-4057qib7 6054 6 tocilizumab tocilizumab NN cord-005453-4057qib7 6054 7 at at IN cord-005453-4057qib7 6054 8 the the DT cord-005453-4057qib7 6054 9 time time NN cord-005453-4057qib7 6054 10 of of IN cord-005453-4057qib7 6054 11 analysis analysis NN cord-005453-4057qib7 6054 12 . . . cord-005453-4057qib7 6055 1 Results result NNS cord-005453-4057qib7 6055 2 : : : cord-005453-4057qib7 6056 1 As as IN cord-005453-4057qib7 6056 2 tocilizumab tocilizumab NNP cord-005453-4057qib7 6056 3 was be VBD cord-005453-4057qib7 6056 4 given give VBN cord-005453-4057qib7 6056 5 fairly fairly RB cord-005453-4057qib7 6056 6 recently recently RB cord-005453-4057qib7 6056 7 in in IN cord-005453-4057qib7 6056 8 most most JJS cord-005453-4057qib7 6056 9 patients patient NNS cord-005453-4057qib7 6056 10 , , , cord-005453-4057qib7 6056 11 6-and 6-and CD cord-005453-4057qib7 6056 12 12-month 12-month JJ cord-005453-4057qib7 6056 13 follow follow NN cord-005453-4057qib7 6056 14 - - HYPH cord-005453-4057qib7 6056 15 up up NN cord-005453-4057qib7 6056 16 was be VBD cord-005453-4057qib7 6056 17 only only RB cord-005453-4057qib7 6056 18 reached reach VBN cord-005453-4057qib7 6056 19 in in IN cord-005453-4057qib7 6056 20 3/ 3/ CD cord-005453-4057qib7 6056 21 9 9 CD cord-005453-4057qib7 6056 22 patients patient NNS cord-005453-4057qib7 6056 23 ( ( -LRB- cord-005453-4057qib7 6056 24 33 33 CD cord-005453-4057qib7 6056 25 % % NN cord-005453-4057qib7 6056 26 ) ) -RRB- cord-005453-4057qib7 6056 27 . . . cord-005453-4057qib7 6057 1 At at IN cord-005453-4057qib7 6057 2 three three CD cord-005453-4057qib7 6057 3 - - HYPH cord-005453-4057qib7 6057 4 month month NN cord-005453-4057qib7 6057 5 follow follow NN cord-005453-4057qib7 6057 6 - - HYPH cord-005453-4057qib7 6057 7 up up NN cord-005453-4057qib7 6057 8 after after IN cord-005453-4057qib7 6057 9 initiation initiation NN cord-005453-4057qib7 6057 10 of of IN cord-005453-4057qib7 6057 11 tocilizumab tocilizumab NNP cord-005453-4057qib7 6057 12 therapy therapy NN cord-005453-4057qib7 6057 13 , , , cord-005453-4057qib7 6057 14 4/9 4/9 CD cord-005453-4057qib7 6057 15 patients patient NNS cord-005453-4057qib7 6057 16 ( ( -LRB- cord-005453-4057qib7 6057 17 44 44 CD cord-005453-4057qib7 6057 18 % % NN cord-005453-4057qib7 6057 19 ) ) -RRB- cord-005453-4057qib7 6057 20 showed show VBD cord-005453-4057qib7 6057 21 partial partial JJ cord-005453-4057qib7 6057 22 remission remission NN cord-005453-4057qib7 6057 23 , , , cord-005453-4057qib7 6057 24 2/9 2/9 CD cord-005453-4057qib7 6057 25 patients patient NNS cord-005453-4057qib7 6057 26 stable stable JJ cord-005453-4057qib7 6057 27 disease disease NN cord-005453-4057qib7 6057 28 ( ( -LRB- cord-005453-4057qib7 6057 29 22 22 CD cord-005453-4057qib7 6057 30 % % NN cord-005453-4057qib7 6057 31 ) ) -RRB- cord-005453-4057qib7 6057 32 , , , cord-005453-4057qib7 6057 33 and and CC cord-005453-4057qib7 6057 34 2/9 2/9 CD cord-005453-4057qib7 6057 35 patients patient NNS cord-005453-4057qib7 6057 36 progressive progressive JJ cord-005453-4057qib7 6057 37 disease disease NN cord-005453-4057qib7 6057 38 ( ( -LRB- cord-005453-4057qib7 6057 39 22 22 CD cord-005453-4057qib7 6057 40 % % NN cord-005453-4057qib7 6057 41 ) ) -RRB- cord-005453-4057qib7 6057 42 of of IN cord-005453-4057qib7 6057 43 cGvHD cGvHD NNP cord-005453-4057qib7 6057 44 . . . cord-005453-4057qib7 6058 1 Maximal maximal JJ cord-005453-4057qib7 6058 2 response response NN cord-005453-4057qib7 6058 3 was be VBD cord-005453-4057qib7 6058 4 partial partial JJ cord-005453-4057qib7 6058 5 remission remission NN cord-005453-4057qib7 6058 6 ( ( -LRB- cord-005453-4057qib7 6058 7 56 56 CD cord-005453-4057qib7 6058 8 % % NN cord-005453-4057qib7 6058 9 ) ) -RRB- cord-005453-4057qib7 6058 10 , , , cord-005453-4057qib7 6058 11 stable stable JJ cord-005453-4057qib7 6058 12 disease disease NN cord-005453-4057qib7 6058 13 ( ( -LRB- cord-005453-4057qib7 6058 14 11 11 CD cord-005453-4057qib7 6058 15 % % NN cord-005453-4057qib7 6058 16 ) ) -RRB- cord-005453-4057qib7 6058 17 and and CC cord-005453-4057qib7 6058 18 progressive progressive JJ cord-005453-4057qib7 6058 19 disease disease NN cord-005453-4057qib7 6058 20 ( ( -LRB- cord-005453-4057qib7 6058 21 22 22 CD cord-005453-4057qib7 6058 22 % % NN cord-005453-4057qib7 6058 23 ) ) -RRB- cord-005453-4057qib7 6058 24 . . . cord-005453-4057qib7 6059 1 3 3 CD cord-005453-4057qib7 6059 2 patients patient NNS cord-005453-4057qib7 6059 3 required require VBD cord-005453-4057qib7 6059 4 subsequent subsequent JJ cord-005453-4057qib7 6059 5 new new JJ cord-005453-4057qib7 6059 6 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6059 7 treatment treatment NN cord-005453-4057qib7 6059 8 . . . cord-005453-4057qib7 6060 1 One one CD cord-005453-4057qib7 6060 2 patient patient NN cord-005453-4057qib7 6060 3 has have VBZ cord-005453-4057qib7 6060 4 not not RB cord-005453-4057qib7 6060 5 yet yet RB cord-005453-4057qib7 6060 6 reached reach VBN cord-005453-4057qib7 6060 7 3-month 3-month CD cord-005453-4057qib7 6060 8 follow follow NN cord-005453-4057qib7 6060 9 - - HYPH cord-005453-4057qib7 6060 10 up up NN cord-005453-4057qib7 6060 11 . . . cord-005453-4057qib7 6061 1 During during IN cord-005453-4057qib7 6061 2 tocilizumab tocilizumab NNP cord-005453-4057qib7 6061 3 therapy therapy NN cord-005453-4057qib7 6061 4 none none NN cord-005453-4057qib7 6061 5 of of IN cord-005453-4057qib7 6061 6 the the DT cord-005453-4057qib7 6061 7 patients patient NNS cord-005453-4057qib7 6061 8 suffered suffer VBD cord-005453-4057qib7 6061 9 recurrence recurrence NN cord-005453-4057qib7 6061 10 of of IN cord-005453-4057qib7 6061 11 underlying underlie VBG cord-005453-4057qib7 6061 12 malignancy malignancy NN cord-005453-4057qib7 6061 13 . . . cord-005453-4057qib7 6062 1 Two two CD cord-005453-4057qib7 6062 2 patients patient NNS cord-005453-4057qib7 6062 3 developed develop VBD cord-005453-4057qib7 6062 4 significant significant JJ cord-005453-4057qib7 6062 5 respiratory respiratory JJ cord-005453-4057qib7 6062 6 infection infection NN cord-005453-4057qib7 6062 7 and and CC cord-005453-4057qib7 6062 8 one one CD cord-005453-4057qib7 6062 9 patient patient NN cord-005453-4057qib7 6062 10 developed develop VBD cord-005453-4057qib7 6062 11 soft soft JJ cord-005453-4057qib7 6062 12 tissue tissue NN cord-005453-4057qib7 6062 13 infection infection NN cord-005453-4057qib7 6062 14 , , , cord-005453-4057qib7 6062 15 all all DT cord-005453-4057qib7 6062 16 requiring require VBG cord-005453-4057qib7 6062 17 antibiotic antibiotic JJ cord-005453-4057qib7 6062 18 treatment treatment NN cord-005453-4057qib7 6062 19 and and CC cord-005453-4057qib7 6062 20 pausing pausing NN cord-005453-4057qib7 6062 21 of of IN cord-005453-4057qib7 6062 22 tocilizumab tocilizumab NNP cord-005453-4057qib7 6062 23 administration administration NN cord-005453-4057qib7 6062 24 , , , cord-005453-4057qib7 6062 25 hospital hospital NN cord-005453-4057qib7 6062 26 admission admission NN cord-005453-4057qib7 6062 27 was be VBD cord-005453-4057qib7 6062 28 not not RB cord-005453-4057qib7 6062 29 required require VBN cord-005453-4057qib7 6062 30 . . . cord-005453-4057qib7 6063 1 The the DT cord-005453-4057qib7 6063 2 OS OS NNP cord-005453-4057qib7 6063 3 and and CC cord-005453-4057qib7 6063 4 RFS RFS NNP cord-005453-4057qib7 6063 5 was be VBD cord-005453-4057qib7 6063 6 100 100 CD cord-005453-4057qib7 6063 7 % % NN cord-005453-4057qib7 6063 8 with with IN cord-005453-4057qib7 6063 9 median median NN cord-005453-4057qib7 6063 10 follow follow NN cord-005453-4057qib7 6063 11 up up IN cord-005453-4057qib7 6063 12 of of IN cord-005453-4057qib7 6063 13 8.5 8.5 CD cord-005453-4057qib7 6063 14 months month NNS cord-005453-4057qib7 6063 15 ( ( -LRB- cord-005453-4057qib7 6063 16 range range VBP cord-005453-4057qib7 6063 17 2 2 CD cord-005453-4057qib7 6063 18 - - SYM cord-005453-4057qib7 6063 19 12 12 CD cord-005453-4057qib7 6063 20 months month NNS cord-005453-4057qib7 6063 21 ) ) -RRB- cord-005453-4057qib7 6063 22 . . . cord-005453-4057qib7 6064 1 Conclusions conclusion NNS cord-005453-4057qib7 6064 2 : : : cord-005453-4057qib7 6065 1 Tocilizumab Tocilizumab NNP cord-005453-4057qib7 6065 2 appears appear VBZ cord-005453-4057qib7 6065 3 to to TO cord-005453-4057qib7 6065 4 be be VB cord-005453-4057qib7 6065 5 a a DT cord-005453-4057qib7 6065 6 promising promising JJ cord-005453-4057qib7 6065 7 treatment treatment NN cord-005453-4057qib7 6065 8 option option NN cord-005453-4057qib7 6065 9 in in IN cord-005453-4057qib7 6065 10 advanced advanced JJ cord-005453-4057qib7 6065 11 cGvHD cgvhd NN cord-005453-4057qib7 6065 12 but but CC cord-005453-4057qib7 6065 13 further further JJ cord-005453-4057qib7 6065 14 evaluation evaluation NN cord-005453-4057qib7 6065 15 within within IN cord-005453-4057qib7 6065 16 a a DT cord-005453-4057qib7 6065 17 phase phase NN cord-005453-4057qib7 6065 18 II II NNP cord-005453-4057qib7 6065 19 trial trial NN cord-005453-4057qib7 6065 20 is be VBZ cord-005453-4057qib7 6065 21 required require VBN cord-005453-4057qib7 6065 22 . . . cord-005453-4057qib7 6066 1 Disclosure disclosure NN cord-005453-4057qib7 6066 2 : : : cord-005453-4057qib7 6066 3 Nothing nothing NN cord-005453-4057qib7 6066 4 to to TO cord-005453-4057qib7 6066 5 declare declare VB cord-005453-4057qib7 6066 6 Background background NN cord-005453-4057qib7 6066 7 : : : cord-005453-4057qib7 6066 8 Allogeneic allogeneic NN cord-005453-4057qib7 6066 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 6066 10 stem stem NN cord-005453-4057qib7 6066 11 cell cell NN cord-005453-4057qib7 6066 12 transplantation transplantation NN cord-005453-4057qib7 6066 13 ( ( -LRB- cord-005453-4057qib7 6066 14 HSCT HSCT NNP cord-005453-4057qib7 6066 15 ) ) -RRB- cord-005453-4057qib7 6066 16 is be VBZ cord-005453-4057qib7 6066 17 for for IN cord-005453-4057qib7 6066 18 many many JJ cord-005453-4057qib7 6066 19 patients patient NNS cord-005453-4057qib7 6066 20 suffering suffer VBG cord-005453-4057qib7 6066 21 from from IN cord-005453-4057qib7 6066 22 AML AML NNP cord-005453-4057qib7 6066 23 the the DT cord-005453-4057qib7 6066 24 only only JJ cord-005453-4057qib7 6066 25 curative curative JJ cord-005453-4057qib7 6066 26 treatment treatment NN cord-005453-4057qib7 6066 27 option option NN cord-005453-4057qib7 6066 28 . . . cord-005453-4057qib7 6067 1 One one CD cord-005453-4057qib7 6067 2 major major JJ cord-005453-4057qib7 6067 3 complication complication NN cord-005453-4057qib7 6067 4 is be VBZ cord-005453-4057qib7 6067 5 graft graft NN cord-005453-4057qib7 6067 6 versus versus IN cord-005453-4057qib7 6067 7 host host NN cord-005453-4057qib7 6067 8 disease disease NN cord-005453-4057qib7 6067 9 ( ( -LRB- cord-005453-4057qib7 6067 10 GvHD GvHD NNP cord-005453-4057qib7 6067 11 ) ) -RRB- cord-005453-4057qib7 6067 12 , , , cord-005453-4057qib7 6067 13 caused cause VBN cord-005453-4057qib7 6067 14 by by IN cord-005453-4057qib7 6067 15 donor donor NN cord-005453-4057qib7 6067 16 immune immune NN cord-005453-4057qib7 6067 17 cells cell NNS cord-005453-4057qib7 6067 18 attacking attack VBG cord-005453-4057qib7 6067 19 healthy healthy JJ cord-005453-4057qib7 6067 20 tissue tissue NN cord-005453-4057qib7 6067 21 . . . cord-005453-4057qib7 6068 1 Regulatory regulatory JJ cord-005453-4057qib7 6068 2 T t NN cord-005453-4057qib7 6068 3 cells cell NNS cord-005453-4057qib7 6068 4 ( ( -LRB- cord-005453-4057qib7 6068 5 Treg Treg NNP cord-005453-4057qib7 6068 6 ) ) -RRB- cord-005453-4057qib7 6068 7 have have VBP cord-005453-4057qib7 6068 8 been be VBN cord-005453-4057qib7 6068 9 getting get VBG cord-005453-4057qib7 6068 10 huge huge JJ cord-005453-4057qib7 6068 11 attention attention NN cord-005453-4057qib7 6068 12 during during IN cord-005453-4057qib7 6068 13 the the DT cord-005453-4057qib7 6068 14 past past JJ cord-005453-4057qib7 6068 15 years year NNS cord-005453-4057qib7 6068 16 because because IN cord-005453-4057qib7 6068 17 of of IN cord-005453-4057qib7 6068 18 their -PRON- PRP$ cord-005453-4057qib7 6068 19 important important JJ cord-005453-4057qib7 6068 20 role role NN cord-005453-4057qib7 6068 21 in in IN cord-005453-4057qib7 6068 22 maintaining maintain VBG cord-005453-4057qib7 6068 23 immune immune JJ cord-005453-4057qib7 6068 24 balance balance NN cord-005453-4057qib7 6068 25 . . . cord-005453-4057qib7 6069 1 Here here RB cord-005453-4057qib7 6069 2 we -PRON- PRP cord-005453-4057qib7 6069 3 collected collect VBD cord-005453-4057qib7 6069 4 peripheral peripheral JJ cord-005453-4057qib7 6069 5 blood blood NN cord-005453-4057qib7 6069 6 samples sample NNS cord-005453-4057qib7 6069 7 from from IN cord-005453-4057qib7 6069 8 11 11 CD cord-005453-4057qib7 6069 9 patients patient NNS cord-005453-4057qib7 6069 10 at at IN cord-005453-4057qib7 6069 11 different different JJ cord-005453-4057qib7 6069 12 time time NN cord-005453-4057qib7 6069 13 points point NNS cord-005453-4057qib7 6069 14 after after IN cord-005453-4057qib7 6069 15 HSCT HSCT NNP cord-005453-4057qib7 6069 16 to to TO cord-005453-4057qib7 6069 17 investigate investigate VB cord-005453-4057qib7 6069 18 immune immune JJ cord-005453-4057qib7 6069 19 - - HYPH cord-005453-4057qib7 6069 20 reconstitution reconstitution NN cord-005453-4057qib7 6069 21 of of IN cord-005453-4057qib7 6069 22 Treg Treg NNP cord-005453-4057qib7 6069 23 as as IN cord-005453-4057qib7 6069 24 predictive predictive JJ cord-005453-4057qib7 6069 25 marker marker NN cord-005453-4057qib7 6069 26 for for IN cord-005453-4057qib7 6069 27 the the DT cord-005453-4057qib7 6069 28 development development NN cord-005453-4057qib7 6069 29 of of IN cord-005453-4057qib7 6069 30 GvHD GvHD NNP cord-005453-4057qib7 6069 31 . . . cord-005453-4057qib7 6070 1 Methods method NNS cord-005453-4057qib7 6070 2 : : : cord-005453-4057qib7 6070 3 We -PRON- PRP cord-005453-4057qib7 6070 4 collected collect VBD cord-005453-4057qib7 6070 5 blood blood NN cord-005453-4057qib7 6070 6 samples sample NNS cord-005453-4057qib7 6070 7 from from IN cord-005453-4057qib7 6070 8 11 11 CD cord-005453-4057qib7 6070 9 patients patient NNS cord-005453-4057qib7 6070 10 in in IN cord-005453-4057qib7 6070 11 the the DT cord-005453-4057qib7 6070 12 course course NN cord-005453-4057qib7 6070 13 of of IN cord-005453-4057qib7 6070 14 allogeneic allogeneic NN cord-005453-4057qib7 6070 15 HSCT HSCT NNP cord-005453-4057qib7 6070 16 prospectively prospectively RB cord-005453-4057qib7 6070 17 once once RB cord-005453-4057qib7 6070 18 a a DT cord-005453-4057qib7 6070 19 week week NN cord-005453-4057qib7 6070 20 from from IN cord-005453-4057qib7 6070 21 d+7 d+7 NNP cord-005453-4057qib7 6070 22 up up IN cord-005453-4057qib7 6070 23 to to IN cord-005453-4057qib7 6070 24 d+200 d+200 NNP cord-005453-4057qib7 6070 25 . . . cord-005453-4057qib7 6071 1 All all DT cord-005453-4057qib7 6071 2 patients patient NNS cord-005453-4057qib7 6071 3 received receive VBD cord-005453-4057qib7 6071 4 conditioning conditioning NN cord-005453-4057qib7 6071 5 regimen regimen NN cord-005453-4057qib7 6071 6 with with IN cord-005453-4057qib7 6071 7 Fludarabine Fludarabine NNP cord-005453-4057qib7 6071 8 and and CC cord-005453-4057qib7 6071 9 Melphalan Melphalan NNP cord-005453-4057qib7 6071 10 , , , cord-005453-4057qib7 6071 11 combined combine VBN cord-005453-4057qib7 6071 12 with with IN cord-005453-4057qib7 6071 13 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 6071 14 for for IN cord-005453-4057qib7 6071 15 T T NNP cord-005453-4057qib7 6071 16 cell cell NN cord-005453-4057qib7 6071 17 depletion depletion NN cord-005453-4057qib7 6071 18 . . . cord-005453-4057qib7 6072 1 9 9 CD cord-005453-4057qib7 6072 2 patients patient NNS cord-005453-4057qib7 6072 3 developed develop VBD cord-005453-4057qib7 6072 4 acute acute JJ cord-005453-4057qib7 6072 5 GVHD GVHD NNP cord-005453-4057qib7 6072 6 in in IN cord-005453-4057qib7 6072 7 the the DT cord-005453-4057qib7 6072 8 later later JJ cord-005453-4057qib7 6072 9 course course NN cord-005453-4057qib7 6072 10 . . . cord-005453-4057qib7 6073 1 After after IN cord-005453-4057qib7 6073 2 isolation isolation NN cord-005453-4057qib7 6073 3 of of IN cord-005453-4057qib7 6073 4 PBMC`s pbmc`s NN cord-005453-4057qib7 6074 1 we -PRON- PRP cord-005453-4057qib7 6074 2 performed perform VBD cord-005453-4057qib7 6074 3 FACS FACS NNP cord-005453-4057qib7 6074 4 multicolor multicolor NN cord-005453-4057qib7 6074 5 staining staining NN cord-005453-4057qib7 6074 6 of of IN cord-005453-4057qib7 6074 7 T T NNP cord-005453-4057qib7 6074 8 cell cell NN cord-005453-4057qib7 6074 9 and and CC cord-005453-4057qib7 6074 10 NK NK NNP cord-005453-4057qib7 6074 11 cells cell NNS cord-005453-4057qib7 6074 12 . . . cord-005453-4057qib7 6075 1 Treg Treg NNP cord-005453-4057qib7 6075 2 were be VBD cord-005453-4057qib7 6075 3 identified identify VBN cord-005453-4057qib7 6075 4 as as IN cord-005453-4057qib7 6075 5 CD3 CD3 NNP cord-005453-4057qib7 6075 6 + + SYM cord-005453-4057qib7 6075 7 CD4 CD4 NNP cord-005453-4057qib7 6075 8 + + CC cord-005453-4057qib7 6075 9 CD25 CD25 NNP cord-005453-4057qib7 6076 1 + + CC cord-005453-4057qib7 6077 1 + + CC cord-005453-4057qib7 6077 2 Foxp3 Foxp3 VBN cord-005453-4057qib7 6078 1 + + UH cord-005453-4057qib7 6078 2 , , , cord-005453-4057qib7 6078 3 NK NK NNP cord-005453-4057qib7 6078 4 cells cell NNS cord-005453-4057qib7 6078 5 were be VBD cord-005453-4057qib7 6078 6 characterized characterize VBN cord-005453-4057qib7 6078 7 as as IN cord-005453-4057qib7 6078 8 CD3 CD3 NNP cord-005453-4057qib7 6078 9 neg neg NNP cord-005453-4057qib7 6078 10 CD56 CD56 NNP cord-005453-4057qib7 6078 11 + + CC cord-005453-4057qib7 6078 12 CD16 CD16 NNP cord-005453-4057qib7 6078 13 + + CC cord-005453-4057qib7 6078 14 and and CC cord-005453-4057qib7 6078 15 divided divide VBN cord-005453-4057qib7 6078 16 in in IN cord-005453-4057qib7 6078 17 NK NK NNP cord-005453-4057qib7 6078 18 cell cell NN cord-005453-4057qib7 6078 19 subpopulation subpopulation NN cord-005453-4057qib7 6078 20 due due IN cord-005453-4057qib7 6078 21 to to IN cord-005453-4057qib7 6078 22 their -PRON- PRP$ cord-005453-4057qib7 6078 23 expression expression NN cord-005453-4057qib7 6078 24 of of IN cord-005453-4057qib7 6078 25 CD56 cd56 NN cord-005453-4057qib7 6078 26 dim dim NN cord-005453-4057qib7 6078 27 or or CC cord-005453-4057qib7 6078 28 CD56 CD56 NNP cord-005453-4057qib7 6078 29 high high JJ cord-005453-4057qib7 6078 30 . . . cord-005453-4057qib7 6079 1 Results result NNS cord-005453-4057qib7 6079 2 : : : cord-005453-4057qib7 6079 3 1 1 CD cord-005453-4057qib7 6079 4 . . . cord-005453-4057qib7 6080 1 CD52 CD52 NNP cord-005453-4057qib7 6080 2 neg neg NN cord-005453-4057qib7 6080 3 T T NNP cord-005453-4057qib7 6080 4 cells cell NNS cord-005453-4057qib7 6080 5 : : : cord-005453-4057qib7 6080 6 all all DT cord-005453-4057qib7 6080 7 patients patient NNS cord-005453-4057qib7 6080 8 developing develop VBG cord-005453-4057qib7 6080 9 acute acute JJ cord-005453-4057qib7 6080 10 GVHD GVHD NNP cord-005453-4057qib7 6080 11 in in IN cord-005453-4057qib7 6080 12 the the DT cord-005453-4057qib7 6080 13 later later JJ cord-005453-4057qib7 6080 14 course course NN cord-005453-4057qib7 6080 15 showed show VBD cord-005453-4057qib7 6080 16 significant significant JJ cord-005453-4057qib7 6080 17 elevated elevated JJ cord-005453-4057qib7 6080 18 levels level NNS cord-005453-4057qib7 6080 19 of of IN cord-005453-4057qib7 6080 20 CD4 CD4 NNP cord-005453-4057qib7 6080 21 + + CC cord-005453-4057qib7 6080 22 CD52 CD52 NNP cord-005453-4057qib7 6080 23 neg neg NN cord-005453-4057qib7 6080 24 T t NN cord-005453-4057qib7 6080 25 cells cell NNS cord-005453-4057qib7 6080 26 , , , cord-005453-4057qib7 6080 27 especially especially RB cord-005453-4057qib7 6080 28 CD52 CD52 NNP cord-005453-4057qib7 6080 29 neg neg NNP cord-005453-4057qib7 6080 30 Treg Treg NNP cord-005453-4057qib7 6080 31 at at IN cord-005453-4057qib7 6080 32 d+50 d+50 NNP cord-005453-4057qib7 6080 33 . . . cord-005453-4057qib7 6080 34 2 2 CD cord-005453-4057qib7 6080 35 . . . cord-005453-4057qib7 6081 1 CD52 CD52 NNP cord-005453-4057qib7 6081 2 neg neg NNP cord-005453-4057qib7 6081 3 Treg Treg NNP cord-005453-4057qib7 6081 4 / / SYM cord-005453-4057qib7 6081 5 CD8 CD8 NNP cord-005453-4057qib7 6081 6 + + CC cord-005453-4057qib7 6081 7 CD52 CD52 NNP cord-005453-4057qib7 6081 8 + + CC cord-005453-4057qib7 6081 9 T t NN cord-005453-4057qib7 6081 10 cells cell NNS cord-005453-4057qib7 6081 11 : : : cord-005453-4057qib7 6081 12 one one CD cord-005453-4057qib7 6081 13 patient patient NN cord-005453-4057qib7 6081 14 not not RB cord-005453-4057qib7 6081 15 developing develop VBG cord-005453-4057qib7 6081 16 acute acute JJ cord-005453-4057qib7 6081 17 GVHD GVHD NNP cord-005453-4057qib7 6081 18 showed show VBD cord-005453-4057qib7 6081 19 lots lot NNS cord-005453-4057qib7 6081 20 of of IN cord-005453-4057qib7 6081 21 CD52 CD52 NNP cord-005453-4057qib7 6081 22 neg neg NNP cord-005453-4057qib7 6081 23 Treg Treg NNP cord-005453-4057qib7 6081 24 but but CC cord-005453-4057qib7 6081 25 missed miss VBD cord-005453-4057qib7 6081 26 CD8 CD8 NNP cord-005453-4057qib7 6081 27 + + CC cord-005453-4057qib7 6081 28 CD52 CD52 NNP cord-005453-4057qib7 6081 29 + + CC cord-005453-4057qib7 6081 30 effector effector VB cord-005453-4057qib7 6081 31 T t NN cord-005453-4057qib7 6081 32 cells cell NNS cord-005453-4057qib7 6081 33 . . . cord-005453-4057qib7 6082 1 We -PRON- PRP cord-005453-4057qib7 6082 2 recently recently RB cord-005453-4057qib7 6082 3 showed show VBD cord-005453-4057qib7 6082 4 that that IN cord-005453-4057qib7 6082 5 CD8 CD8 NNP cord-005453-4057qib7 6082 6 + + SYM cord-005453-4057qib7 6082 7 CD52 CD52 NNP cord-005453-4057qib7 6082 8 neg neg NN cord-005453-4057qib7 6082 9 effector effector NN cord-005453-4057qib7 6082 10 T t NN cord-005453-4057qib7 6082 11 cells cell NNS cord-005453-4057qib7 6082 12 are be VBP cord-005453-4057qib7 6082 13 of of IN cord-005453-4057qib7 6082 14 impaired impair VBN cord-005453-4057qib7 6082 15 effector effector NN cord-005453-4057qib7 6082 16 function function NN cord-005453-4057qib7 6082 17 . . . cord-005453-4057qib7 6083 1 These these DT cord-005453-4057qib7 6083 2 data datum NNS cord-005453-4057qib7 6083 3 suggest suggest VBP cord-005453-4057qib7 6083 4 that that IN cord-005453-4057qib7 6083 5 CD52 CD52 NNP cord-005453-4057qib7 6083 6 neg neg NNP cord-005453-4057qib7 6083 7 Treg Treg NNP cord-005453-4057qib7 6083 8 are be VBP cord-005453-4057qib7 6083 9 only only RB cord-005453-4057qib7 6083 10 of of IN cord-005453-4057qib7 6083 11 relevance relevance NN cord-005453-4057qib7 6083 12 combined combine VBN cord-005453-4057qib7 6083 13 with with IN cord-005453-4057qib7 6083 14 functional functional JJ cord-005453-4057qib7 6083 15 CD8 CD8 NNS cord-005453-4057qib7 6083 16 + + CC cord-005453-4057qib7 6083 17 CD52 CD52 NNP cord-005453-4057qib7 6083 18 + + CC cord-005453-4057qib7 6083 19 effector effector VB cord-005453-4057qib7 6083 20 T t NN cord-005453-4057qib7 6083 21 cells cell NNS cord-005453-4057qib7 6083 22 in in IN cord-005453-4057qib7 6083 23 the the DT cord-005453-4057qib7 6083 24 development development NN cord-005453-4057qib7 6083 25 of of IN cord-005453-4057qib7 6083 26 aGVHD aGVHD NNP cord-005453-4057qib7 6083 27 . . . cord-005453-4057qib7 6084 1 3 3 LS cord-005453-4057qib7 6084 2 . . . cord-005453-4057qib7 6085 1 T T NNP cord-005453-4057qib7 6085 2 cell cell NN cord-005453-4057qib7 6085 3 marker marker NN cord-005453-4057qib7 6085 4 : : : cord-005453-4057qib7 6085 5 Patients patient NNS cord-005453-4057qib7 6085 6 without without IN cord-005453-4057qib7 6085 7 aGVHD aGVHD NNP cord-005453-4057qib7 6085 8 showed show VBD cord-005453-4057qib7 6085 9 elevated elevated JJ cord-005453-4057qib7 6085 10 expression expression NN cord-005453-4057qib7 6085 11 of of IN cord-005453-4057qib7 6085 12 Garp Garp NNP cord-005453-4057qib7 6085 13 on on IN cord-005453-4057qib7 6085 14 Treg Treg NNP cord-005453-4057qib7 6085 15 . . . cord-005453-4057qib7 6086 1 Garp Garp NNP cord-005453-4057qib7 6086 2 was be VBD cord-005453-4057qib7 6086 3 significantly significantly RB cord-005453-4057qib7 6086 4 higher high JJR cord-005453-4057qib7 6086 5 expressed express VBN cord-005453-4057qib7 6086 6 on on IN cord-005453-4057qib7 6086 7 CD52 CD52 NNP cord-005453-4057qib7 6086 8 + + CC cord-005453-4057qib7 6086 9 Treg Treg NNP cord-005453-4057qib7 6086 10 , , , cord-005453-4057qib7 6086 11 indicating indicate VBG cord-005453-4057qib7 6086 12 a a DT cord-005453-4057qib7 6086 13 better well JJR cord-005453-4057qib7 6086 14 suppressive suppressive JJ cord-005453-4057qib7 6086 15 capacity capacity NN cord-005453-4057qib7 6086 16 of of IN cord-005453-4057qib7 6086 17 CD52 CD52 NNP cord-005453-4057qib7 6086 18 + + CC cord-005453-4057qib7 6086 19 Treg Treg NNP cord-005453-4057qib7 6086 20 . . . cord-005453-4057qib7 6087 1 This this DT cord-005453-4057qib7 6087 2 was be VBD cord-005453-4057qib7 6087 3 detected detect VBN cord-005453-4057qib7 6087 4 throughout throughout IN cord-005453-4057qib7 6087 5 from from IN cord-005453-4057qib7 6087 6 d+50 d+50 NNP cord-005453-4057qib7 6087 7 until until IN cord-005453-4057qib7 6087 8 d+200 d+200 NNP cord-005453-4057qib7 6087 9 . . . cord-005453-4057qib7 6088 1 Tigit Tigit NNP cord-005453-4057qib7 6088 2 and and CC cord-005453-4057qib7 6088 3 ILT3 ILT3 NNP cord-005453-4057qib7 6088 4 showed show VBD cord-005453-4057qib7 6088 5 a a DT cord-005453-4057qib7 6088 6 heterogeneous heterogeneous JJ cord-005453-4057qib7 6088 7 expression expression NN cord-005453-4057qib7 6088 8 profile profile NN cord-005453-4057qib7 6088 9 without without IN cord-005453-4057qib7 6088 10 significant significant JJ cord-005453-4057qib7 6088 11 differences difference NNS cord-005453-4057qib7 6088 12 between between IN cord-005453-4057qib7 6088 13 the the DT cord-005453-4057qib7 6088 14 two two CD cord-005453-4057qib7 6088 15 groups group NNS cord-005453-4057qib7 6088 16 . . . cord-005453-4057qib7 6089 1 4 4 LS cord-005453-4057qib7 6089 2 . . . cord-005453-4057qib7 6090 1 NK NK NNP cord-005453-4057qib7 6090 2 cells cell NNS cord-005453-4057qib7 6091 1 : : : cord-005453-4057qib7 6091 2 We -PRON- PRP cord-005453-4057qib7 6091 3 detected detect VBD cord-005453-4057qib7 6091 4 a a DT cord-005453-4057qib7 6091 5 higher high JJR cord-005453-4057qib7 6091 6 ratio ratio NN cord-005453-4057qib7 6091 7 of of IN cord-005453-4057qib7 6091 8 CD65 CD65 NNP cord-005453-4057qib7 6091 9 + + . cord-005453-4057qib7 6092 1 + + CC cord-005453-4057qib7 6092 2 /CD56 /CD56 NNP cord-005453-4057qib7 6092 3 dim dim JJ cord-005453-4057qib7 6092 4 NK nk NN cord-005453-4057qib7 6092 5 - - HYPH cord-005453-4057qib7 6092 6 cell cell NN cord-005453-4057qib7 6092 7 population population NN cord-005453-4057qib7 6092 8 in in IN cord-005453-4057qib7 6092 9 patients patient NNS cord-005453-4057qib7 6092 10 without without IN cord-005453-4057qib7 6092 11 . . . cord-005453-4057qib7 6093 1 We -PRON- PRP cord-005453-4057qib7 6093 2 could could MD cord-005453-4057qib7 6093 3 also also RB cord-005453-4057qib7 6093 4 show show VB cord-005453-4057qib7 6093 5 that that IN cord-005453-4057qib7 6093 6 Tigit Tigit NNP cord-005453-4057qib7 6093 7 is be VBZ cord-005453-4057qib7 6093 8 mainly mainly RB cord-005453-4057qib7 6093 9 expressed express VBN cord-005453-4057qib7 6093 10 on on IN cord-005453-4057qib7 6093 11 CD56 CD56 NNP cord-005453-4057qib7 6093 12 dim dim NN cord-005453-4057qib7 6093 13 NK NK NNP cord-005453-4057qib7 6093 14 cells cell NNS cord-005453-4057qib7 6093 15 . . . cord-005453-4057qib7 6094 1 Conclusions conclusion NNS cord-005453-4057qib7 6094 2 : : : cord-005453-4057qib7 6095 1 We -PRON- PRP cord-005453-4057qib7 6095 2 and and CC cord-005453-4057qib7 6095 3 others other NNS cord-005453-4057qib7 6095 4 showed show VBD cord-005453-4057qib7 6095 5 reconstitution reconstitution NN cord-005453-4057qib7 6095 6 of of IN cord-005453-4057qib7 6095 7 CD52 CD52 NNP cord-005453-4057qib7 6095 8 neg neg JJ cord-005453-4057qib7 6095 9 T t NN cord-005453-4057qib7 6095 10 cell cell NN cord-005453-4057qib7 6095 11 subsets subset NNS cord-005453-4057qib7 6095 12 after after IN cord-005453-4057qib7 6095 13 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 6095 14 mediated mediate VBD cord-005453-4057qib7 6095 15 T t NN cord-005453-4057qib7 6095 16 cell cell NN cord-005453-4057qib7 6095 17 depletion depletion NN cord-005453-4057qib7 6095 18 -our -our : cord-005453-4057qib7 6095 19 data datum NNS cord-005453-4057qib7 6095 20 on on IN cord-005453-4057qib7 6095 21 effector effector NN cord-005453-4057qib7 6095 22 T T NNP cord-005453-4057qib7 6095 23 cells cell NNS cord-005453-4057qib7 6095 24 showed show VBD cord-005453-4057qib7 6095 25 an an DT cord-005453-4057qib7 6095 26 impaired impaired JJ cord-005453-4057qib7 6095 27 effector effector NN cord-005453-4057qib7 6095 28 function function NN cord-005453-4057qib7 6095 29 for for IN cord-005453-4057qib7 6095 30 CD52 CD52 NNP cord-005453-4057qib7 6095 31 neg neg NN cord-005453-4057qib7 6095 32 CD4 CD4 NNP cord-005453-4057qib7 6095 33 and and CC cord-005453-4057qib7 6095 34 CD8 CD8 NNP cord-005453-4057qib7 6095 35 T T NNP cord-005453-4057qib7 6095 36 cells cell NNS cord-005453-4057qib7 6095 37 . . . cord-005453-4057qib7 6096 1 Recently recently RB cord-005453-4057qib7 6096 2 we -PRON- PRP cord-005453-4057qib7 6096 3 presented present VBD cord-005453-4057qib7 6096 4 Data Data NNP cord-005453-4057qib7 6096 5 on on IN cord-005453-4057qib7 6096 6 impaired impaired JJ cord-005453-4057qib7 6096 7 suppressive suppressive JJ cord-005453-4057qib7 6096 8 capacity capacity NN cord-005453-4057qib7 6096 9 of of IN cord-005453-4057qib7 6096 10 CD52 CD52 NNP cord-005453-4057qib7 6096 11 neg neg NNP cord-005453-4057qib7 6096 12 Treg Treg NNP cord-005453-4057qib7 6096 13 and and CC cord-005453-4057qib7 6096 14 the the DT cord-005453-4057qib7 6096 15 association association NN cord-005453-4057qib7 6096 16 with with IN cord-005453-4057qib7 6096 17 acute acute JJ cord-005453-4057qib7 6096 18 GVHD GVHD NNP cord-005453-4057qib7 6096 19 retrospectively retrospectively RB cord-005453-4057qib7 6096 20 ( ( -LRB- cord-005453-4057qib7 6096 21 Wölfinger Wölfinger NNP cord-005453-4057qib7 6096 22 EBMT EBMT NNP cord-005453-4057qib7 6096 23 2018 2018 CD cord-005453-4057qib7 6096 24 , , , cord-005453-4057qib7 6096 25 ASH ASH NNP cord-005453-4057qib7 6096 26 2017 2017 CD cord-005453-4057qib7 6096 27 ) ) -RRB- cord-005453-4057qib7 6096 28 . . . cord-005453-4057qib7 6097 1 Here here RB cord-005453-4057qib7 6097 2 we -PRON- PRP cord-005453-4057qib7 6097 3 provide provide VBP cord-005453-4057qib7 6097 4 prospective prospective JJ cord-005453-4057qib7 6097 5 Data datum NNS cord-005453-4057qib7 6097 6 on on IN cord-005453-4057qib7 6097 7 patients patient NNS cord-005453-4057qib7 6097 8 after after IN cord-005453-4057qib7 6097 9 the the DT cord-005453-4057qib7 6097 10 use use NN cord-005453-4057qib7 6097 11 of of IN cord-005453-4057qib7 6097 12 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 6097 13 in in IN cord-005453-4057qib7 6097 14 the the DT cord-005453-4057qib7 6097 15 context context NN cord-005453-4057qib7 6097 16 of of IN cord-005453-4057qib7 6097 17 HSCT HSCT NNP cord-005453-4057qib7 6097 18 : : : cord-005453-4057qib7 6098 1 Our -PRON- PRP$ cord-005453-4057qib7 6098 2 preliminary preliminary JJ cord-005453-4057qib7 6098 3 data datum NNS cord-005453-4057qib7 6098 4 suggest suggest VBP cord-005453-4057qib7 6098 5 that that IN cord-005453-4057qib7 6098 6 the the DT cord-005453-4057qib7 6098 7 total total JJ cord-005453-4057qib7 6098 8 amount amount NN cord-005453-4057qib7 6098 9 of of IN cord-005453-4057qib7 6098 10 CD52 CD52 NNP cord-005453-4057qib7 6098 11 neg neg NNP cord-005453-4057qib7 6098 12 - - NNP cord-005453-4057qib7 6098 13 Treg Treg NNP cord-005453-4057qib7 6098 14 and and CC cord-005453-4057qib7 6098 15 the the DT cord-005453-4057qib7 6098 16 ratio ratio NN cord-005453-4057qib7 6098 17 of of IN cord-005453-4057qib7 6098 18 CD52 CD52 NNP cord-005453-4057qib7 6098 19 neg neg NNP cord-005453-4057qib7 6098 20 Treg Treg NNP cord-005453-4057qib7 6098 21 to to IN cord-005453-4057qib7 6098 22 CD8 CD8 NNP cord-005453-4057qib7 6098 23 + + CC cord-005453-4057qib7 6098 24 CD52 CD52 NNP cord-005453-4057qib7 6099 1 + + CC cord-005453-4057qib7 6100 1 Treg Treg NNP cord-005453-4057qib7 6100 2 on on IN cord-005453-4057qib7 6100 3 d+50 d+50 NN cord-005453-4057qib7 6100 4 after after IN cord-005453-4057qib7 6100 5 allogenic allogenic JJ cord-005453-4057qib7 6100 6 HSCT HSCT NNP cord-005453-4057qib7 6100 7 could could MD cord-005453-4057qib7 6100 8 predict predict VB cord-005453-4057qib7 6100 9 aGvHD agvhd NN cord-005453-4057qib7 6100 10 . . . cord-005453-4057qib7 6101 1 This this DT cord-005453-4057qib7 6101 2 data datum NNS cord-005453-4057qib7 6101 3 may may MD cord-005453-4057qib7 6101 4 be be VB cord-005453-4057qib7 6101 5 a a DT cord-005453-4057qib7 6101 6 basis basis NN cord-005453-4057qib7 6101 7 for for IN cord-005453-4057qib7 6101 8 immune immune JJ cord-005453-4057qib7 6101 9 monitoring monitoring NN cord-005453-4057qib7 6101 10 of of IN cord-005453-4057qib7 6101 11 patients patient NNS cord-005453-4057qib7 6101 12 at at IN cord-005453-4057qib7 6101 13 d+50 d+50 NNP cord-005453-4057qib7 6101 14 to to TO cord-005453-4057qib7 6101 15 evaluate evaluate VB cord-005453-4057qib7 6101 16 their -PRON- PRP$ cord-005453-4057qib7 6101 17 risk risk NN cord-005453-4057qib7 6101 18 for for IN cord-005453-4057qib7 6101 19 aGVHD aGVHD NNP cord-005453-4057qib7 6101 20 and and CC cord-005453-4057qib7 6101 21 could could MD cord-005453-4057qib7 6101 22 lead lead VB cord-005453-4057qib7 6101 23 to to IN cord-005453-4057qib7 6101 24 the the DT cord-005453-4057qib7 6101 25 use use NN cord-005453-4057qib7 6101 26 of of IN cord-005453-4057qib7 6101 27 prophylactic prophylactic JJ cord-005453-4057qib7 6101 28 Treg Treg NNP cord-005453-4057qib7 6101 29 DLI DLI NNP cord-005453-4057qib7 6101 30 in in IN cord-005453-4057qib7 6101 31 the the DT cord-005453-4057qib7 6101 32 context context NN cord-005453-4057qib7 6101 33 of of IN cord-005453-4057qib7 6101 34 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 6101 35 mediated mediate VBD cord-005453-4057qib7 6101 36 T t NN cord-005453-4057qib7 6101 37 cell cell NN cord-005453-4057qib7 6101 38 depletion depletion NN cord-005453-4057qib7 6101 39 . . . cord-005453-4057qib7 6102 1 Disclosure disclosure NN cord-005453-4057qib7 6102 2 : : : cord-005453-4057qib7 6103 1 Medac Medac NNP cord-005453-4057qib7 6103 2 -travel -travel NNP cord-005453-4057qib7 6103 3 support support NN cord-005453-4057qib7 6103 4 , , , cord-005453-4057qib7 6103 5 Novartis Novartis NNP cord-005453-4057qib7 6103 6 -consultancy -consultancy NNP cord-005453-4057qib7 6103 7 fee fee NN cord-005453-4057qib7 6103 8 , , , cord-005453-4057qib7 6103 9 Pfizer Pfizer NNP cord-005453-4057qib7 6103 10 -consultancy -consultancy NNP cord-005453-4057qib7 6103 11 fee fee NN cord-005453-4057qib7 6104 1 , , , cord-005453-4057qib7 6104 2 Shireconsultancy Shireconsultancy NNP cord-005453-4057qib7 6104 3 fee fee NN cord-005453-4057qib7 6104 4 Background Background NNP cord-005453-4057qib7 6104 5 : : : cord-005453-4057qib7 6105 1 Multiple multiple JJ cord-005453-4057qib7 6105 2 factors factor NNS cord-005453-4057qib7 6105 3 such such JJ cord-005453-4057qib7 6105 4 as as IN cord-005453-4057qib7 6105 5 disease disease NN cord-005453-4057qib7 6105 6 activity activity NN cord-005453-4057qib7 6105 7 and and CC cord-005453-4057qib7 6105 8 severity severity NN cord-005453-4057qib7 6105 9 , , , cord-005453-4057qib7 6105 10 therapy therapy NN cord-005453-4057qib7 6105 11 and/or and/or CC cord-005453-4057qib7 6105 12 dietary dietary JJ cord-005453-4057qib7 6105 13 habits habit NNS cord-005453-4057qib7 6105 14 can can MD cord-005453-4057qib7 6105 15 cause cause VB cord-005453-4057qib7 6105 16 changes change NNS cord-005453-4057qib7 6105 17 in in IN cord-005453-4057qib7 6105 18 nutritional nutritional JJ cord-005453-4057qib7 6105 19 status status NN cord-005453-4057qib7 6105 20 independently independently RB cord-005453-4057qib7 6105 21 or or CC cord-005453-4057qib7 6105 22 by by IN cord-005453-4057qib7 6105 23 interacting interact VBG cord-005453-4057qib7 6105 24 with with IN cord-005453-4057qib7 6105 25 each each DT cord-005453-4057qib7 6105 26 other other JJ cord-005453-4057qib7 6105 27 . . . cord-005453-4057qib7 6106 1 Presence presence NN cord-005453-4057qib7 6106 2 of of IN cord-005453-4057qib7 6106 3 malnutrition malnutrition NN cord-005453-4057qib7 6106 4 or or CC cord-005453-4057qib7 6106 5 significant significant JJ cord-005453-4057qib7 6106 6 weight weight NN cord-005453-4057qib7 6106 7 loss loss NN cord-005453-4057qib7 6106 8 in in IN cord-005453-4057qib7 6106 9 chronic chronic JJ cord-005453-4057qib7 6106 10 GVHD GVHD NNP cord-005453-4057qib7 6106 11 ( ( -LRB- cord-005453-4057qib7 6106 12 cGVHD cGVHD NNP cord-005453-4057qib7 6106 13 ) ) -RRB- cord-005453-4057qib7 6106 14 patients patient NNS cord-005453-4057qib7 6106 15 was be VBD cord-005453-4057qib7 6106 16 reported report VBN cord-005453-4057qib7 6106 17 in in IN cord-005453-4057qib7 6106 18 literature literature NN cord-005453-4057qib7 6106 19 up up IN cord-005453-4057qib7 6106 20 to to TO cord-005453-4057qib7 6106 21 43 43 CD cord-005453-4057qib7 6106 22 % % NN cord-005453-4057qib7 6106 23 . . . cord-005453-4057qib7 6107 1 The the DT cord-005453-4057qib7 6107 2 aim aim NN cord-005453-4057qib7 6107 3 of of IN cord-005453-4057qib7 6107 4 this this DT cord-005453-4057qib7 6107 5 cross cross JJ cord-005453-4057qib7 6107 6 - - JJ cord-005453-4057qib7 6107 7 sectional sectional JJ cord-005453-4057qib7 6107 8 study study NN cord-005453-4057qib7 6107 9 was be VBD cord-005453-4057qib7 6107 10 to to TO cord-005453-4057qib7 6107 11 identify identify VB cord-005453-4057qib7 6107 12 factors factor NNS cord-005453-4057qib7 6107 13 that that WDT cord-005453-4057qib7 6107 14 affect affect VBP cord-005453-4057qib7 6107 15 nutritional nutritional JJ cord-005453-4057qib7 6107 16 status status NN cord-005453-4057qib7 6107 17 in in IN cord-005453-4057qib7 6107 18 cGVHD cGVHD NNP cord-005453-4057qib7 6107 19 patients patient NNS cord-005453-4057qib7 6107 20 . . . cord-005453-4057qib7 6108 1 Methods method NNS cord-005453-4057qib7 6108 2 : : : cord-005453-4057qib7 6108 3 Nutritional nutritional JJ cord-005453-4057qib7 6108 4 status status NN cord-005453-4057qib7 6108 5 in in IN cord-005453-4057qib7 6108 6 patients patient NNS cord-005453-4057qib7 6108 7 with with IN cord-005453-4057qib7 6108 8 cGVHD cGVHD NNP cord-005453-4057qib7 6108 9 treated treat VBN cord-005453-4057qib7 6108 10 at at IN cord-005453-4057qib7 6108 11 the the DT cord-005453-4057qib7 6108 12 University University NNP cord-005453-4057qib7 6108 13 Hospital Hospital NNP cord-005453-4057qib7 6108 14 Center Center NNP cord-005453-4057qib7 6108 15 Zagreb Zagreb NNP cord-005453-4057qib7 6108 16 , , , cord-005453-4057qib7 6109 1 Croatia Croatia NNP cord-005453-4057qib7 6109 2 from from IN cord-005453-4057qib7 6109 3 2015 2015 CD cord-005453-4057qib7 6109 4 to to IN cord-005453-4057qib7 6109 5 2018 2018 CD cord-005453-4057qib7 6109 6 was be VBD cord-005453-4057qib7 6109 7 assessed assess VBN cord-005453-4057qib7 6109 8 . . . cord-005453-4057qib7 6110 1 Anthropometric anthropometric JJ cord-005453-4057qib7 6110 2 measurements measurement NNS cord-005453-4057qib7 6110 3 ( ( -LRB- cord-005453-4057qib7 6110 4 height height NN cord-005453-4057qib7 6110 5 , , , cord-005453-4057qib7 6110 6 body body NN cord-005453-4057qib7 6110 7 weight weight NN cord-005453-4057qib7 6110 8 ( ( -LRB- cord-005453-4057qib7 6110 9 BW BW NNP cord-005453-4057qib7 6110 10 ) ) -RRB- cord-005453-4057qib7 6110 11 , , , cord-005453-4057qib7 6110 12 body body NN cord-005453-4057qib7 6110 13 mass mass NN cord-005453-4057qib7 6110 14 index index NN cord-005453-4057qib7 6110 15 ( ( -LRB- cord-005453-4057qib7 6110 16 BMI BMI NNP cord-005453-4057qib7 6110 17 ) ) -RRB- cord-005453-4057qib7 6110 18 ) ) -RRB- cord-005453-4057qib7 6110 19 and and CC cord-005453-4057qib7 6110 20 clinical clinical JJ cord-005453-4057qib7 6110 21 validated validate VBN cord-005453-4057qib7 6110 22 tool tool NN cord-005453-4057qib7 6110 23 patient patient NN cord-005453-4057qib7 6110 24 - - HYPH cord-005453-4057qib7 6110 25 generated generate VBN cord-005453-4057qib7 6110 26 subjective subjective JJ cord-005453-4057qib7 6110 27 global global JJ cord-005453-4057qib7 6110 28 assessment assessment NN cord-005453-4057qib7 6110 29 ( ( -LRB- cord-005453-4057qib7 6110 30 PG PG NNP cord-005453-4057qib7 6110 31 - - HYPH cord-005453-4057qib7 6110 32 SGA SGA NNP cord-005453-4057qib7 6110 33 ) ) -RRB- cord-005453-4057qib7 6110 34 ( ( -LRB- cord-005453-4057qib7 6110 35 where where WRB cord-005453-4057qib7 6110 36 patients patient NNS cord-005453-4057qib7 6110 37 were be VBD cord-005453-4057qib7 6110 38 categorized categorize VBN cord-005453-4057qib7 6110 39 as as RB cord-005453-4057qib7 6110 40 well well RB cord-005453-4057qib7 6110 41 - - HYPH cord-005453-4057qib7 6110 42 nourished nourish VBN cord-005453-4057qib7 6110 43 ( ( -LRB- cord-005453-4057qib7 6110 44 PG PG NNP cord-005453-4057qib7 6110 45 - - HYPH cord-005453-4057qib7 6110 46 SGA SGA NNP cord-005453-4057qib7 6110 47 A A NNP cord-005453-4057qib7 6110 48 ) ) -RRB- cord-005453-4057qib7 6110 49 , , , cord-005453-4057qib7 6110 50 moderately moderately RB cord-005453-4057qib7 6110 51 malnourished malnourished JJ cord-005453-4057qib7 6110 52 ( ( -LRB- cord-005453-4057qib7 6110 53 PG PG NNP cord-005453-4057qib7 6110 54 - - HYPH cord-005453-4057qib7 6110 55 SGA SGA NNP cord-005453-4057qib7 6110 56 B B NNP cord-005453-4057qib7 6110 57 ) ) -RRB- cord-005453-4057qib7 6110 58 or or CC cord-005453-4057qib7 6110 59 severely severely RB cord-005453-4057qib7 6110 60 malnourished malnourished JJ cord-005453-4057qib7 6110 61 ( ( -LRB- cord-005453-4057qib7 6110 62 PG PG NNP cord-005453-4057qib7 6110 63 - - HYPH cord-005453-4057qib7 6110 64 SGA SGA NNP cord-005453-4057qib7 6110 65 C C NNP cord-005453-4057qib7 6110 66 ) ) -RRB- cord-005453-4057qib7 6110 67 ) ) -RRB- cord-005453-4057qib7 6110 68 were be VBD cord-005453-4057qib7 6110 69 used use VBN cord-005453-4057qib7 6110 70 . . . cord-005453-4057qib7 6111 1 All all DT cord-005453-4057qib7 6111 2 patients patient NNS cord-005453-4057qib7 6111 3 were be VBD cord-005453-4057qib7 6111 4 evaluated evaluate VBN cord-005453-4057qib7 6111 5 according accord VBG cord-005453-4057qib7 6111 6 to to IN cord-005453-4057qib7 6111 7 2005 2005 CD cord-005453-4057qib7 6111 8 NIH NIH NNP cord-005453-4057qib7 6111 9 criteria criterion NNS cord-005453-4057qib7 6111 10 for for IN cord-005453-4057qib7 6111 11 cGVHD cGVHD NNP cord-005453-4057qib7 6111 12 diagnosis diagnosis NN cord-005453-4057qib7 6111 13 . . . cord-005453-4057qib7 6112 1 Descriptive descriptive JJ cord-005453-4057qib7 6112 2 and and CC cord-005453-4057qib7 6112 3 correlation correlation NN cord-005453-4057qib7 6112 4 analysis analysis NN cord-005453-4057qib7 6112 5 were be VBD cord-005453-4057qib7 6112 6 preformed preform VBN cord-005453-4057qib7 6112 7 . . . cord-005453-4057qib7 6113 1 Results result NNS cord-005453-4057qib7 6113 2 : : : cord-005453-4057qib7 6114 1 In in IN cord-005453-4057qib7 6114 2 total total NN cord-005453-4057qib7 6114 3 , , , cord-005453-4057qib7 6114 4 44 44 CD cord-005453-4057qib7 6114 5 adult adult NN cord-005453-4057qib7 6114 6 cGVHD cgvhd NN cord-005453-4057qib7 6114 7 patients patient NNS cord-005453-4057qib7 6114 8 were be VBD cord-005453-4057qib7 6114 9 included include VBN cord-005453-4057qib7 6114 10 in in IN cord-005453-4057qib7 6114 11 the the DT cord-005453-4057qib7 6114 12 study study NN cord-005453-4057qib7 6114 13 , , , cord-005453-4057qib7 6114 14 23 23 CD cord-005453-4057qib7 6114 15 women woman NNS cord-005453-4057qib7 6114 16 ( ( -LRB- cord-005453-4057qib7 6114 17 52.3 52.3 CD cord-005453-4057qib7 6114 18 % % NN cord-005453-4057qib7 6114 19 ) ) -RRB- cord-005453-4057qib7 6114 20 , , , cord-005453-4057qib7 6114 21 median median JJ cord-005453-4057qib7 6114 22 age age NN cord-005453-4057qib7 6114 23 47 47 CD cord-005453-4057qib7 6114 24 ( ( -LRB- cord-005453-4057qib7 6114 25 18 18 CD cord-005453-4057qib7 6114 26 - - SYM cord-005453-4057qib7 6114 27 65 65 CD cord-005453-4057qib7 6114 28 ) ) -RRB- cord-005453-4057qib7 6114 29 years year NNS cord-005453-4057qib7 6114 30 , , , cord-005453-4057qib7 6114 31 with with IN cord-005453-4057qib7 6114 32 mild mild JJ cord-005453-4057qib7 6114 33 cGVHD cgvhd NN cord-005453-4057qib7 6114 34 in in IN cord-005453-4057qib7 6114 35 6 6 CD cord-005453-4057qib7 6114 36 ( ( -LRB- cord-005453-4057qib7 6114 37 13.64 13.64 CD cord-005453-4057qib7 6114 38 % % NN cord-005453-4057qib7 6114 39 ) ) -RRB- cord-005453-4057qib7 6114 40 , , , cord-005453-4057qib7 6114 41 moderate moderate JJ cord-005453-4057qib7 6114 42 in in IN cord-005453-4057qib7 6114 43 24 24 CD cord-005453-4057qib7 6114 44 ( ( -LRB- cord-005453-4057qib7 6114 45 54.55 54.55 CD cord-005453-4057qib7 6114 46 % % NN cord-005453-4057qib7 6114 47 ) ) -RRB- cord-005453-4057qib7 6114 48 and and CC cord-005453-4057qib7 6114 49 severe severe JJ cord-005453-4057qib7 6114 50 in in IN cord-005453-4057qib7 6114 51 13 13 CD cord-005453-4057qib7 6114 52 ( ( -LRB- cord-005453-4057qib7 6114 53 29.55 29.55 CD cord-005453-4057qib7 6114 54 % % NN cord-005453-4057qib7 6114 55 ) ) -RRB- cord-005453-4057qib7 6114 56 patients patient NNS cord-005453-4057qib7 6114 57 . . . cord-005453-4057qib7 6115 1 According accord VBG cord-005453-4057qib7 6115 2 to to IN cord-005453-4057qib7 6115 3 the the DT cord-005453-4057qib7 6115 4 PG PG NNP cord-005453-4057qib7 6115 5 - - HYPH cord-005453-4057qib7 6115 6 SGA SGA NNP cord-005453-4057qib7 6115 7 rating rating NN cord-005453-4057qib7 6115 8 19 19 CD cord-005453-4057qib7 6115 9 ( ( -LRB- cord-005453-4057qib7 6115 10 43.18 43.18 CD cord-005453-4057qib7 6115 11 % % NN cord-005453-4057qib7 6115 12 ) ) -RRB- cord-005453-4057qib7 6115 13 patients patient NNS cord-005453-4057qib7 6115 14 had have VBD cord-005453-4057qib7 6115 15 PG PG NNP cord-005453-4057qib7 6115 16 - - HYPH cord-005453-4057qib7 6115 17 SGA SGA NNP cord-005453-4057qib7 6115 18 A A NNP cord-005453-4057qib7 6115 19 , , , cord-005453-4057qib7 6115 20 19 19 CD cord-005453-4057qib7 6115 21 ( ( -LRB- cord-005453-4057qib7 6115 22 43.18 43.18 CD cord-005453-4057qib7 6115 23 % % NN cord-005453-4057qib7 6115 24 ) ) -RRB- cord-005453-4057qib7 6116 1 PG PG NNP cord-005453-4057qib7 6116 2 - - HYPH cord-005453-4057qib7 6116 3 SGA SGA NNP cord-005453-4057qib7 6116 4 B B NNP cord-005453-4057qib7 6116 5 and and CC cord-005453-4057qib7 6116 6 6 6 CD cord-005453-4057qib7 6116 7 ( ( -LRB- cord-005453-4057qib7 6116 8 13.64 13.64 CD cord-005453-4057qib7 6116 9 % % NN cord-005453-4057qib7 6116 10 ) ) -RRB- cord-005453-4057qib7 6116 11 had have VBD cord-005453-4057qib7 6116 12 PG PG NNP cord-005453-4057qib7 6116 13 - - HYPH cord-005453-4057qib7 6116 14 SGA SGA NNP cord-005453-4057qib7 6116 15 C C NNP cord-005453-4057qib7 6116 16 , , , cord-005453-4057qib7 6116 17 giving give VBG cord-005453-4057qib7 6116 18 a a DT cord-005453-4057qib7 6116 19 total total JJ cord-005453-4057qib7 6116 20 malnutrition malnutrition NN cord-005453-4057qib7 6116 21 or or CC cord-005453-4057qib7 6116 22 risk risk NN cord-005453-4057qib7 6116 23 of of IN cord-005453-4057qib7 6116 24 malnutrition malnutrition NN cord-005453-4057qib7 6116 25 prevalence prevalence NN cord-005453-4057qib7 6116 26 of of IN cord-005453-4057qib7 6116 27 56.82 56.82 CD cord-005453-4057qib7 6116 28 % % NN cord-005453-4057qib7 6116 29 . . . cord-005453-4057qib7 6117 1 The the DT cord-005453-4057qib7 6117 2 mean mean JJ cord-005453-4057qib7 6117 3 BMI BMI NNP cord-005453-4057qib7 6117 4 was be VBD cord-005453-4057qib7 6117 5 23.83±4.3 23.83±4.3 CD cord-005453-4057qib7 6117 6 kg kg NNP cord-005453-4057qib7 6117 7 / / SYM cord-005453-4057qib7 6117 8 m m NN cord-005453-4057qib7 6117 9 2 2 CD cord-005453-4057qib7 6117 10 with with IN cord-005453-4057qib7 6117 11 correlation correlation NN cord-005453-4057qib7 6117 12 to to IN cord-005453-4057qib7 6117 13 PG PG NNP cord-005453-4057qib7 6117 14 - - HYPH cord-005453-4057qib7 6117 15 SGA SGA NNP cord-005453-4057qib7 6117 16 rating rating NN cord-005453-4057qib7 6117 17 ( ( -LRB- cord-005453-4057qib7 6117 18 r=0.446 r=0.446 NNP cord-005453-4057qib7 6117 19 , , , cord-005453-4057qib7 6117 20 p=0.0024 p=0.0024 NNP cord-005453-4057qib7 6117 21 ) ) -RRB- cord-005453-4057qib7 6117 22 . . . cord-005453-4057qib7 6118 1 Malnutrition malnutrition NN cord-005453-4057qib7 6118 2 according accord VBG cord-005453-4057qib7 6118 3 to to IN cord-005453-4057qib7 6118 4 the the DT cord-005453-4057qib7 6118 5 BMI BMI NNP cord-005453-4057qib7 6118 6 ( ( -LRB- cord-005453-4057qib7 6118 7 defined define VBN cord-005453-4057qib7 6118 8 as as IN cord-005453-4057qib7 6118 9 BMI BMI NNP cord-005453-4057qib7 6118 10 < < XX cord-005453-4057qib7 6118 11 21 21 CD cord-005453-4057qib7 6118 12 kg kg NNS cord-005453-4057qib7 6119 1 /m /m NNP cord-005453-4057qib7 6119 2 2 2 LS cord-005453-4057qib7 6119 3 ) ) -RRB- cord-005453-4057qib7 6119 4 was be VBD cord-005453-4057qib7 6119 5 found find VBN cord-005453-4057qib7 6119 6 in in IN cord-005453-4057qib7 6119 7 8 8 CD cord-005453-4057qib7 6119 8 patients patient NNS cord-005453-4057qib7 6119 9 ( ( -LRB- cord-005453-4057qib7 6119 10 18.18 18.18 CD cord-005453-4057qib7 6119 11 % % NN cord-005453-4057qib7 6119 12 ) ) -RRB- cord-005453-4057qib7 6119 13 . . . cord-005453-4057qib7 6120 1 BW BW NNP cord-005453-4057qib7 6120 2 changes change NNS cord-005453-4057qib7 6120 3 ( ( -LRB- cord-005453-4057qib7 6120 4 10 10 CD cord-005453-4057qib7 6120 5 % % NN cord-005453-4057qib7 6120 6 or or CC cord-005453-4057qib7 6120 7 more more JJR cord-005453-4057qib7 6120 8 in in IN cord-005453-4057qib7 6120 9 6 6 CD cord-005453-4057qib7 6120 10 months month NNS cord-005453-4057qib7 6120 11 ) ) -RRB- cord-005453-4057qib7 6120 12 were be VBD cord-005453-4057qib7 6120 13 significant significant JJ cord-005453-4057qib7 6120 14 in in IN cord-005453-4057qib7 6120 15 14 14 CD cord-005453-4057qib7 6120 16 patients patient NNS cord-005453-4057qib7 6120 17 ( ( -LRB- cord-005453-4057qib7 6120 18 31.82 31.82 CD cord-005453-4057qib7 6120 19 % % NN cord-005453-4057qib7 6120 20 ) ) -RRB- cord-005453-4057qib7 6120 21 . . . cord-005453-4057qib7 6121 1 According accord VBG cord-005453-4057qib7 6121 2 to to IN cord-005453-4057qib7 6121 3 the the DT cord-005453-4057qib7 6121 4 PG PG NNP cord-005453-4057qib7 6121 5 - - HYPH cord-005453-4057qib7 6121 6 SGA SGA NNP cord-005453-4057qib7 6121 7 assessment assessment NN cord-005453-4057qib7 6121 8 tool tool NN cord-005453-4057qib7 6121 9 , , , cord-005453-4057qib7 6121 10 oral oral JJ cord-005453-4057qib7 6121 11 symptoms symptom NNS cord-005453-4057qib7 6121 12 reported report VBN cord-005453-4057qib7 6121 13 by by IN cord-005453-4057qib7 6121 14 31 31 CD cord-005453-4057qib7 6121 15 patient patient NN cord-005453-4057qib7 6121 16 ( ( -LRB- cord-005453-4057qib7 6121 17 70.45 70.45 CD cord-005453-4057qib7 6121 18 % % NN cord-005453-4057qib7 6121 19 ) ) -RRB- cord-005453-4057qib7 6121 20 and and CC cord-005453-4057qib7 6121 21 decreased decrease VBD cord-005453-4057qib7 6121 22 appetite appetite NN cord-005453-4057qib7 6121 23 reported report VBN cord-005453-4057qib7 6121 24 by by IN cord-005453-4057qib7 6121 25 12 12 CD cord-005453-4057qib7 6121 26 patients patient NNS cord-005453-4057qib7 6121 27 ( ( -LRB- cord-005453-4057qib7 6121 28 27.27 27.27 CD cord-005453-4057qib7 6121 29 % % NN cord-005453-4057qib7 6121 30 ) ) -RRB- cord-005453-4057qib7 6121 31 were be VBD cord-005453-4057qib7 6121 32 associated associate VBN cord-005453-4057qib7 6121 33 with with IN cord-005453-4057qib7 6121 34 oral oral JJ cord-005453-4057qib7 6121 35 cGVHD cGVHD NNP cord-005453-4057qib7 6121 36 NIH NIH NNP cord-005453-4057qib7 6121 37 score score NN cord-005453-4057qib7 6121 38 ( ( -LRB- cord-005453-4057qib7 6121 39 r=0.536 r=0.536 NN cord-005453-4057qib7 6121 40 , , , cord-005453-4057qib7 6121 41 p=0.0002 p=0.0002 UH cord-005453-4057qib7 6121 42 ; ; : cord-005453-4057qib7 6121 43 r=0.441 r=0.441 NNP cord-005453-4057qib7 6121 44 , , , cord-005453-4057qib7 6121 45 p=0.0027 p=0.0027 NNP cord-005453-4057qib7 6121 46 ) ) -RRB- cord-005453-4057qib7 6121 47 but but CC cord-005453-4057qib7 6121 48 not not RB cord-005453-4057qib7 6121 49 with with IN cord-005453-4057qib7 6121 50 BW BW NNP cord-005453-4057qib7 6121 51 or or CC cord-005453-4057qib7 6121 52 BMI BMI NNP cord-005453-4057qib7 6121 53 . . . cord-005453-4057qib7 6122 1 Gastrointestinal gastrointestinal JJ cord-005453-4057qib7 6122 2 ( ( -LRB- cord-005453-4057qib7 6122 3 GI GI NNP cord-005453-4057qib7 6122 4 ) ) -RRB- cord-005453-4057qib7 6122 5 symptoms symptom NNS cord-005453-4057qib7 6122 6 assessed assess VBN cord-005453-4057qib7 6122 7 with with IN cord-005453-4057qib7 6122 8 SGA SGA NNP cord-005453-4057qib7 6122 9 , , , cord-005453-4057qib7 6122 10 were be VBD cord-005453-4057qib7 6122 11 generally generally RB cord-005453-4057qib7 6122 12 mild mild JJ cord-005453-4057qib7 6122 13 with with IN cord-005453-4057qib7 6122 14 no no DT cord-005453-4057qib7 6122 15 correlation correlation NN cord-005453-4057qib7 6122 16 to to IN cord-005453-4057qib7 6122 17 GI GI NNP cord-005453-4057qib7 6122 18 cGVHD cGVHD NNP cord-005453-4057qib7 6122 19 NIH NIH NNP cord-005453-4057qib7 6122 20 score score NN cord-005453-4057qib7 6122 21 . . . cord-005453-4057qib7 6123 1 No no DT cord-005453-4057qib7 6123 2 significant significant JJ cord-005453-4057qib7 6123 3 association association NN cord-005453-4057qib7 6123 4 was be VBD cord-005453-4057qib7 6123 5 found find VBN cord-005453-4057qib7 6123 6 between between IN cord-005453-4057qib7 6123 7 nutritional nutritional JJ cord-005453-4057qib7 6123 8 status status NN cord-005453-4057qib7 6123 9 and and CC cord-005453-4057qib7 6123 10 other other JJ cord-005453-4057qib7 6123 11 NIH NIH NNP cord-005453-4057qib7 6123 12 cGVHD cGVHD NNP cord-005453-4057qib7 6123 13 scores score NNS cord-005453-4057qib7 6123 14 . . . cord-005453-4057qib7 6124 1 Corticosteroid Corticosteroid NNP cord-005453-4057qib7 6124 2 therapy therapy NN cord-005453-4057qib7 6124 3 present present NN cord-005453-4057qib7 6124 4 in in IN cord-005453-4057qib7 6124 5 12 12 CD cord-005453-4057qib7 6124 6 ( ( -LRB- cord-005453-4057qib7 6124 7 27.27 27.27 CD cord-005453-4057qib7 6124 8 % % NN cord-005453-4057qib7 6124 9 ) ) -RRB- cord-005453-4057qib7 6124 10 correlated correlate VBN cord-005453-4057qib7 6124 11 with with IN cord-005453-4057qib7 6124 12 PG PG NNP cord-005453-4057qib7 6124 13 - - HYPH cord-005453-4057qib7 6124 14 SGA SGA NNP cord-005453-4057qib7 6124 15 rating rating NN cord-005453-4057qib7 6124 16 ( ( -LRB- cord-005453-4057qib7 6124 17 r=0.494 r=0.494 NNS cord-005453-4057qib7 6124 18 , , , cord-005453-4057qib7 6124 19 p=0.0006 p=0.0006 NNP cord-005453-4057qib7 6124 20 ) ) -RRB- cord-005453-4057qib7 6124 21 but but CC cord-005453-4057qib7 6124 22 not not RB cord-005453-4057qib7 6124 23 with with IN cord-005453-4057qib7 6124 24 BW BW NNP cord-005453-4057qib7 6124 25 , , , cord-005453-4057qib7 6124 26 BMI BMI NNP cord-005453-4057qib7 6124 27 or or CC cord-005453-4057qib7 6124 28 appetite appetite NN cord-005453-4057qib7 6124 29 changes change NNS cord-005453-4057qib7 6124 30 . . . cord-005453-4057qib7 6125 1 In in IN cord-005453-4057qib7 6125 2 23 23 CD cord-005453-4057qib7 6125 3 patients patient NNS cord-005453-4057qib7 6125 4 ( ( -LRB- cord-005453-4057qib7 6125 5 52.7 52.7 CD cord-005453-4057qib7 6125 6 % % NN cord-005453-4057qib7 6125 7 ) ) -RRB- cord-005453-4057qib7 6125 8 with with IN cord-005453-4057qib7 6125 9 altered alter VBN cord-005453-4057qib7 6125 10 PG PG NNP cord-005453-4057qib7 6125 11 - - HYPH cord-005453-4057qib7 6125 12 SGA SGA NNP cord-005453-4057qib7 6125 13 rating rating NN cord-005453-4057qib7 6125 14 , , , cord-005453-4057qib7 6125 15 BMI BMI NNP cord-005453-4057qib7 6125 16 , , , cord-005453-4057qib7 6125 17 appetite appetite NN cord-005453-4057qib7 6125 18 and and CC cord-005453-4057qib7 6125 19 body body NN cord-005453-4057qib7 6125 20 weight weight NN cord-005453-4057qib7 6125 21 changes change NNS cord-005453-4057qib7 6125 22 , , , cord-005453-4057qib7 6125 23 dietary dietary JJ cord-005453-4057qib7 6125 24 counseling counseling NN cord-005453-4057qib7 6125 25 and and CC cord-005453-4057qib7 6125 26 oral oral JJ cord-005453-4057qib7 6125 27 nutritional nutritional JJ cord-005453-4057qib7 6125 28 supplementation supplementation NN cord-005453-4057qib7 6125 29 were be VBD cord-005453-4057qib7 6125 30 initiated initiate VBN cord-005453-4057qib7 6125 31 . . . cord-005453-4057qib7 6126 1 Conclusions conclusion NNS cord-005453-4057qib7 6126 2 : : : cord-005453-4057qib7 6127 1 Oral oral JJ cord-005453-4057qib7 6127 2 symptoms symptom NNS cord-005453-4057qib7 6127 3 , , , cord-005453-4057qib7 6127 4 decreased decrease VBD cord-005453-4057qib7 6127 5 appetite appetite NN cord-005453-4057qib7 6127 6 and and CC cord-005453-4057qib7 6127 7 corticosteroid corticosteroid NN cord-005453-4057qib7 6127 8 therapy therapy NN cord-005453-4057qib7 6127 9 in in IN cord-005453-4057qib7 6127 10 our -PRON- PRP$ cord-005453-4057qib7 6127 11 cGVHD cgvhd NN cord-005453-4057qib7 6127 12 patients patient NNS cord-005453-4057qib7 6127 13 were be VBD cord-005453-4057qib7 6127 14 associated associate VBN cord-005453-4057qib7 6127 15 with with IN cord-005453-4057qib7 6127 16 altered altered JJ cord-005453-4057qib7 6127 17 nutritional nutritional JJ cord-005453-4057qib7 6127 18 status status NN cord-005453-4057qib7 6127 19 according accord VBG cord-005453-4057qib7 6127 20 to to IN cord-005453-4057qib7 6127 21 the the DT cord-005453-4057qib7 6127 22 PG PG NNP cord-005453-4057qib7 6127 23 - - HYPH cord-005453-4057qib7 6127 24 SGA SGA NNP cord-005453-4057qib7 6127 25 , , , cord-005453-4057qib7 6127 26 but but CC cord-005453-4057qib7 6127 27 not not RB cord-005453-4057qib7 6127 28 with with IN cord-005453-4057qib7 6127 29 BMI BMI NNP cord-005453-4057qib7 6127 30 . . . cord-005453-4057qib7 6128 1 Therefore therefore RB cord-005453-4057qib7 6128 2 , , , cord-005453-4057qib7 6128 3 PG PG NNP cord-005453-4057qib7 6128 4 - - HYPH cord-005453-4057qib7 6128 5 SGA SGA NNP cord-005453-4057qib7 6128 6 might may MD cord-005453-4057qib7 6128 7 be be VB cord-005453-4057qib7 6128 8 a a DT cord-005453-4057qib7 6128 9 more more RBR cord-005453-4057qib7 6128 10 sensitive sensitive JJ cord-005453-4057qib7 6128 11 tool tool NN cord-005453-4057qib7 6128 12 in in IN cord-005453-4057qib7 6128 13 assessment assessment NN cord-005453-4057qib7 6128 14 of of IN cord-005453-4057qib7 6128 15 changes change NNS cord-005453-4057qib7 6128 16 of of IN cord-005453-4057qib7 6128 17 the the DT cord-005453-4057qib7 6128 18 nutritional nutritional JJ cord-005453-4057qib7 6128 19 status status NN cord-005453-4057qib7 6128 20 and and CC cord-005453-4057qib7 6128 21 detection detection NN cord-005453-4057qib7 6128 22 of of IN cord-005453-4057qib7 6128 23 patients patient NNS cord-005453-4057qib7 6128 24 at at IN cord-005453-4057qib7 6128 25 risk risk NN cord-005453-4057qib7 6128 26 of of IN cord-005453-4057qib7 6128 27 malnutrition malnutrition NN cord-005453-4057qib7 6128 28 than than IN cord-005453-4057qib7 6128 29 BMI BMI NNP cord-005453-4057qib7 6128 30 since since IN cord-005453-4057qib7 6128 31 it -PRON- PRP cord-005453-4057qib7 6128 32 includes include VBZ cord-005453-4057qib7 6128 33 different different JJ cord-005453-4057qib7 6128 34 factors factor NNS cord-005453-4057qib7 6128 35 like like IN cord-005453-4057qib7 6128 36 physical physical JJ cord-005453-4057qib7 6128 37 examination examination NN cord-005453-4057qib7 6128 38 , , , cord-005453-4057qib7 6128 39 presence presence NN cord-005453-4057qib7 6128 40 of of IN cord-005453-4057qib7 6128 41 GI GI NNP cord-005453-4057qib7 6128 42 symptoms symptom NNS cord-005453-4057qib7 6128 43 and and CC cord-005453-4057qib7 6128 44 corticosteroid corticosteroid NN cord-005453-4057qib7 6128 45 therapy therapy NN cord-005453-4057qib7 6128 46 in in IN cord-005453-4057qib7 6128 47 its -PRON- PRP$ cord-005453-4057qib7 6128 48 scoring scoring NN cord-005453-4057qib7 6128 49 system system NN cord-005453-4057qib7 6128 50 . . . cord-005453-4057qib7 6129 1 Nutritional nutritional JJ cord-005453-4057qib7 6129 2 counseling counseling NN cord-005453-4057qib7 6129 3 and and CC cord-005453-4057qib7 6129 4 support support NN cord-005453-4057qib7 6129 5 are be VBP cord-005453-4057qib7 6129 6 important important JJ cord-005453-4057qib7 6129 7 in in IN cord-005453-4057qib7 6129 8 cGVHD cgvhd NN cord-005453-4057qib7 6129 9 patients patient NNS cord-005453-4057qib7 6129 10 especially especially RB cord-005453-4057qib7 6129 11 in in IN cord-005453-4057qib7 6129 12 presence presence NN cord-005453-4057qib7 6129 13 of of IN cord-005453-4057qib7 6129 14 oral oral JJ cord-005453-4057qib7 6129 15 symptoms symptom NNS cord-005453-4057qib7 6129 16 . . . cord-005453-4057qib7 6130 1 Disclosure disclosure NN cord-005453-4057qib7 6130 2 : : : cord-005453-4057qib7 6130 3 Nothing nothing NN cord-005453-4057qib7 6130 4 to to TO cord-005453-4057qib7 6130 5 declare declare VB cord-005453-4057qib7 6130 6 . . . cord-005453-4057qib7 6131 1 Background background NN cord-005453-4057qib7 6131 2 : : : cord-005453-4057qib7 6132 1 Sclerotic sclerotic JJ cord-005453-4057qib7 6132 2 skin skin NN cord-005453-4057qib7 6132 3 changes change NNS cord-005453-4057qib7 6132 4 are be VBP cord-005453-4057qib7 6132 5 common common JJ cord-005453-4057qib7 6132 6 features feature NNS cord-005453-4057qib7 6132 7 in in IN cord-005453-4057qib7 6132 8 chronic chronic JJ cord-005453-4057qib7 6132 9 graft graft NN cord-005453-4057qib7 6132 10 versus versus IN cord-005453-4057qib7 6132 11 host host NN cord-005453-4057qib7 6132 12 disease disease NN cord-005453-4057qib7 6132 13 ( ( -LRB- cord-005453-4057qib7 6132 14 cGVHD cGVHD NNP cord-005453-4057qib7 6132 15 ) ) -RRB- cord-005453-4057qib7 6132 16 . . . cord-005453-4057qib7 6133 1 One one CD cord-005453-4057qib7 6133 2 of of IN cord-005453-4057qib7 6133 3 the the DT cord-005453-4057qib7 6133 4 most most RBS cord-005453-4057qib7 6133 5 challenging challenging JJ cord-005453-4057qib7 6133 6 aspects aspect NNS cord-005453-4057qib7 6133 7 in in IN cord-005453-4057qib7 6133 8 the the DT cord-005453-4057qib7 6133 9 diagnosis diagnosis NN cord-005453-4057qib7 6133 10 and and CC cord-005453-4057qib7 6133 11 management management NN cord-005453-4057qib7 6133 12 of of IN cord-005453-4057qib7 6133 13 sclerodermoid sclerodermoid NNP cord-005453-4057qib7 6133 14 cGVHD cGVHD NNP cord-005453-4057qib7 6134 1 ( ( -LRB- cord-005453-4057qib7 6134 2 scGVHD scGVHD NNP cord-005453-4057qib7 6134 3 ) ) -RRB- cord-005453-4057qib7 6134 4 is be VBZ cord-005453-4057qib7 6134 5 the the DT cord-005453-4057qib7 6134 6 differentiation differentiation NN cord-005453-4057qib7 6134 7 between between IN cord-005453-4057qib7 6134 8 reversible reversible JJ cord-005453-4057qib7 6134 9 symptoms symptom NNS cord-005453-4057qib7 6134 10 related relate VBN cord-005453-4057qib7 6134 11 to to IN cord-005453-4057qib7 6134 12 active active JJ cord-005453-4057qib7 6134 13 cGVHD cgvhd NN cord-005453-4057qib7 6134 14 and and CC cord-005453-4057qib7 6134 15 nonreversible nonreversible JJ cord-005453-4057qib7 6134 16 symptoms symptom NNS cord-005453-4057qib7 6134 17 related relate VBN cord-005453-4057qib7 6134 18 to to IN cord-005453-4057qib7 6134 19 residual residual JJ cord-005453-4057qib7 6134 20 permanent permanent JJ cord-005453-4057qib7 6134 21 damage damage NN cord-005453-4057qib7 6134 22 such such JJ cord-005453-4057qib7 6134 23 as as IN cord-005453-4057qib7 6134 24 long long RB cord-005453-4057qib7 6134 25 - - HYPH cord-005453-4057qib7 6134 26 standing stand VBG cord-005453-4057qib7 6134 27 fibrosis fibrosis NN cord-005453-4057qib7 6134 28 . . . cord-005453-4057qib7 6135 1 Although although IN cord-005453-4057qib7 6135 2 several several JJ cord-005453-4057qib7 6135 3 candidate candidate NN cord-005453-4057qib7 6135 4 biomarkers biomarker NNS cord-005453-4057qib7 6135 5 of of IN cord-005453-4057qib7 6135 6 cGVHD cGVHD NNP cord-005453-4057qib7 6135 7 inflammatory inflammatory JJ cord-005453-4057qib7 6135 8 activity activity NN cord-005453-4057qib7 6135 9 have have VBP cord-005453-4057qib7 6135 10 been be VBN cord-005453-4057qib7 6135 11 proposed propose VBN cord-005453-4057qib7 6135 12 , , , cord-005453-4057qib7 6135 13 none none NN cord-005453-4057qib7 6135 14 of of IN cord-005453-4057qib7 6135 15 them -PRON- PRP cord-005453-4057qib7 6135 16 are be VBP cord-005453-4057qib7 6135 17 currently currently RB cord-005453-4057qib7 6135 18 validated validate VBN cord-005453-4057qib7 6135 19 . . . cord-005453-4057qib7 6136 1 Therefore therefore RB cord-005453-4057qib7 6136 2 , , , cord-005453-4057qib7 6136 3 there there EX cord-005453-4057qib7 6136 4 is be VBZ cord-005453-4057qib7 6136 5 a a DT cord-005453-4057qib7 6136 6 need need NN cord-005453-4057qib7 6136 7 for for IN cord-005453-4057qib7 6136 8 the the DT cord-005453-4057qib7 6136 9 development development NN cord-005453-4057qib7 6136 10 of of IN cord-005453-4057qib7 6136 11 more more RBR cord-005453-4057qib7 6136 12 quantifiable quantifiable JJ cord-005453-4057qib7 6136 13 and and CC cord-005453-4057qib7 6136 14 reproducible reproducible JJ cord-005453-4057qib7 6136 15 measurements measurement NNS cord-005453-4057qib7 6136 16 tools tool NNS cord-005453-4057qib7 6136 17 to to TO cord-005453-4057qib7 6136 18 guide guide VB cord-005453-4057qib7 6136 19 clinical clinical JJ cord-005453-4057qib7 6136 20 decisions decision NNS cord-005453-4057qib7 6136 21 . . . cord-005453-4057qib7 6137 1 We -PRON- PRP cord-005453-4057qib7 6137 2 report report VBP cord-005453-4057qib7 6137 3 our -PRON- PRP$ cord-005453-4057qib7 6137 4 experience experience NN cord-005453-4057qib7 6137 5 evaluating evaluate VBG cord-005453-4057qib7 6137 6 the the DT cord-005453-4057qib7 6137 7 usefulness usefulness NN cord-005453-4057qib7 6137 8 of of IN cord-005453-4057qib7 6137 9 high high JJ cord-005453-4057qib7 6137 10 - - HYPH cord-005453-4057qib7 6137 11 frequency frequency NN cord-005453-4057qib7 6137 12 ultrasonography ultrasonography NN cord-005453-4057qib7 6137 13 ( ( -LRB- cord-005453-4057qib7 6137 14 HFUS HFUS NNP cord-005453-4057qib7 6137 15 ) ) -RRB- cord-005453-4057qib7 6137 16 plus plus CC cord-005453-4057qib7 6137 17 Doppler Doppler NNP cord-005453-4057qib7 6137 18 ultrasound ultrasound NN cord-005453-4057qib7 6137 19 ( ( -LRB- cord-005453-4057qib7 6137 20 Doppler Doppler NNP cord-005453-4057qib7 6137 21 - - HYPH cord-005453-4057qib7 6137 22 US US NNP cord-005453-4057qib7 6137 23 ) ) -RRB- cord-005453-4057qib7 6137 24 and and CC cord-005453-4057qib7 6137 25 serum serum NN cord-005453-4057qib7 6137 26 fibrosis fibrosis NN cord-005453-4057qib7 6137 27 biomarkers biomarker NNS cord-005453-4057qib7 6137 28 to to TO cord-005453-4057qib7 6137 29 determine determine VB cord-005453-4057qib7 6137 30 the the DT cord-005453-4057qib7 6137 31 inflammatory inflammatory JJ cord-005453-4057qib7 6137 32 activity activity NN cord-005453-4057qib7 6137 33 of of IN cord-005453-4057qib7 6137 34 scGVHD scgvhd ADD cord-005453-4057qib7 6137 35 . . . cord-005453-4057qib7 6138 1 Methods method NNS cord-005453-4057qib7 6138 2 : : : cord-005453-4057qib7 6139 1 We -PRON- PRP cord-005453-4057qib7 6139 2 report report VBP cord-005453-4057qib7 6139 3 6 6 CD cord-005453-4057qib7 6139 4 patients patient NNS cord-005453-4057qib7 6139 5 with with IN cord-005453-4057qib7 6139 6 scGVHD scgvhd ADD cord-005453-4057qib7 6139 7 . . . cord-005453-4057qib7 6140 1 HFUS HFUS NNP cord-005453-4057qib7 6140 2 plus plus CC cord-005453-4057qib7 6140 3 Doppler Doppler NNP cord-005453-4057qib7 6140 4 - - HYPH cord-005453-4057qib7 6140 5 US US NNP cord-005453-4057qib7 6140 6 were be VBD cord-005453-4057qib7 6140 7 performed perform VBN cord-005453-4057qib7 6140 8 at at IN cord-005453-4057qib7 6140 9 diagnosis diagnosis NN cord-005453-4057qib7 6140 10 of of IN cord-005453-4057qib7 6140 11 scGVHD scGVHD NNP cord-005453-4057qib7 6140 12 and and CC cord-005453-4057qib7 6140 13 at at IN cord-005453-4057qib7 6140 14 different different JJ cord-005453-4057qib7 6140 15 time time NN cord-005453-4057qib7 6140 16 - - HYPH cord-005453-4057qib7 6140 17 points point NNS cord-005453-4057qib7 6140 18 after after IN cord-005453-4057qib7 6140 19 treatment treatment NN cord-005453-4057qib7 6140 20 initiation initiation NN cord-005453-4057qib7 6140 21 . . . cord-005453-4057qib7 6141 1 Serum serum NN cord-005453-4057qib7 6141 2 hyaluronic hyaluronic NN cord-005453-4057qib7 6141 3 acid acid NN cord-005453-4057qib7 6141 4 and and CC cord-005453-4057qib7 6141 5 pro pro JJ cord-005453-4057qib7 6141 6 - - JJ cord-005453-4057qib7 6141 7 colagen colagen JJ cord-005453-4057qib7 6141 8 - - HYPH cord-005453-4057qib7 6141 9 III III NNP cord-005453-4057qib7 6141 10 were be VBD cord-005453-4057qib7 6141 11 measured measure VBN cord-005453-4057qib7 6141 12 as as IN cord-005453-4057qib7 6141 13 fibrosis fibrosis NN cord-005453-4057qib7 6141 14 biomarkers biomarker NNS cord-005453-4057qib7 6141 15 simultaneously simultaneously RB cord-005453-4057qib7 6141 16 with with IN cord-005453-4057qib7 6141 17 HFUS HFUS NNP cord-005453-4057qib7 6141 18 and and CC cord-005453-4057qib7 6141 19 Doppler Doppler NNP cord-005453-4057qib7 6141 20 - - HYPH cord-005453-4057qib7 6141 21 US US NNP cord-005453-4057qib7 6141 22 . . . cord-005453-4057qib7 6142 1 NIH NIH NNP cord-005453-4057qib7 6142 2 cGVHD cGVHD NNP cord-005453-4057qib7 6142 3 2014 2014 CD cord-005453-4057qib7 6142 4 Consensus Consensus NNP cord-005453-4057qib7 6142 5 Conference Conference NNP cord-005453-4057qib7 6142 6 diagnosis diagnosis NN cord-005453-4057qib7 6142 7 criteria criterion NNS cord-005453-4057qib7 6142 8 , , , cord-005453-4057qib7 6142 9 scoring score VBG cord-005453-4057qib7 6142 10 system system NN cord-005453-4057qib7 6142 11 , , , cord-005453-4057qib7 6142 12 and and CC cord-005453-4057qib7 6142 13 response response NN cord-005453-4057qib7 6142 14 criteria criterion NNS cord-005453-4057qib7 6142 15 were be VBD cord-005453-4057qib7 6142 16 used use VBN cord-005453-4057qib7 6142 17 to to TO cord-005453-4057qib7 6142 18 assess assess VB cord-005453-4057qib7 6142 19 global global JJ cord-005453-4057qib7 6142 20 and and CC cord-005453-4057qib7 6142 21 organ organ NN cord-005453-4057qib7 6142 22 - - HYPH cord-005453-4057qib7 6142 23 specific specific JJ cord-005453-4057qib7 6142 24 cGVHD cgvhd NN cord-005453-4057qib7 6142 25 , , , cord-005453-4057qib7 6142 26 and and CC cord-005453-4057qib7 6142 27 to to TO cord-005453-4057qib7 6142 28 measure measure VB cord-005453-4057qib7 6142 29 overall overall JJ cord-005453-4057qib7 6142 30 response response NN cord-005453-4057qib7 6142 31 to to IN cord-005453-4057qib7 6142 32 therapy therapy NN cord-005453-4057qib7 6142 33 . . . cord-005453-4057qib7 6143 1 Abnormal abnormal JJ cord-005453-4057qib7 6143 2 ultrasound ultrasound NN cord-005453-4057qib7 6143 3 findings finding NNS cord-005453-4057qib7 6143 4 were be VBD cord-005453-4057qib7 6143 5 defined define VBN cord-005453-4057qib7 6143 6 as as IN cord-005453-4057qib7 6143 7 the the DT cord-005453-4057qib7 6143 8 presence presence NN cord-005453-4057qib7 6143 9 of of IN cord-005453-4057qib7 6143 10 ≥ ≥ CD cord-005453-4057qib7 6143 11 1 1 CD cord-005453-4057qib7 6143 12 of of IN cord-005453-4057qib7 6143 13 the the DT cord-005453-4057qib7 6143 14 following follow VBG cord-005453-4057qib7 6143 15 : : : cord-005453-4057qib7 6143 16 hypoechogenic hypoechogenic NNP cord-005453-4057qib7 6143 17 dermis dermis NN cord-005453-4057qib7 6143 18 , , , cord-005453-4057qib7 6143 19 dermo dermo NN cord-005453-4057qib7 6143 20 - - HYPH cord-005453-4057qib7 6143 21 epidermal epidermal JJ cord-005453-4057qib7 6143 22 junction junction NN cord-005453-4057qib7 6143 23 effacement effacement NN cord-005453-4057qib7 6143 24 , , , cord-005453-4057qib7 6143 25 hypoechogenicity hypoechogenicity NN cord-005453-4057qib7 6143 26 of of IN cord-005453-4057qib7 6143 27 septa septa NNP cord-005453-4057qib7 6143 28 and/or and/or CC cord-005453-4057qib7 6143 29 hyperechogenicity hyperechogenicity NN cord-005453-4057qib7 6143 30 of of IN cord-005453-4057qib7 6143 31 lobules lobule NNS cord-005453-4057qib7 6143 32 in in IN cord-005453-4057qib7 6143 33 hypodermis hypodermis NNP cord-005453-4057qib7 6143 34 , , , cord-005453-4057qib7 6143 35 hypoechogenic hypoechogenic NNP cord-005453-4057qib7 6143 36 fascia fascia NN cord-005453-4057qib7 6143 37 , , , cord-005453-4057qib7 6143 38 or or CC cord-005453-4057qib7 6143 39 myositis myositis NN cord-005453-4057qib7 6143 40 , , , cord-005453-4057qib7 6143 41 for for IN cord-005453-4057qib7 6143 42 HFUS HFUS NNP cord-005453-4057qib7 6143 43 ; ; : cord-005453-4057qib7 6143 44 and and CC cord-005453-4057qib7 6143 45 , , , cord-005453-4057qib7 6143 46 vessels vessel NNS cord-005453-4057qib7 6143 47 thicker thick JJR cord-005453-4057qib7 6143 48 than than IN cord-005453-4057qib7 6143 49 1 1 CD cord-005453-4057qib7 6143 50 mm mm NNS cord-005453-4057qib7 6143 51 in in IN cord-005453-4057qib7 6143 52 dermis dermis NN cord-005453-4057qib7 6143 53 and/or and/or CC cord-005453-4057qib7 6143 54 hypodermis hypodermis NNP cord-005453-4057qib7 6143 55 , , , cord-005453-4057qib7 6143 56 systolic systolic JJ cord-005453-4057qib7 6143 57 pressure pressure NN cord-005453-4057qib7 6143 58 > > XX cord-005453-4057qib7 6143 59 10 10 CD cord-005453-4057qib7 6143 60 cm cm NNS cord-005453-4057qib7 6143 61 / / SYM cord-005453-4057qib7 6143 62 sec sec NNP cord-005453-4057qib7 6143 63 , , , cord-005453-4057qib7 6143 64 and and CC cord-005453-4057qib7 6143 65 index index NN cord-005453-4057qib7 6143 66 of of IN cord-005453-4057qib7 6143 67 vascular vascular JJ cord-005453-4057qib7 6143 68 resistance resistance NN cord-005453-4057qib7 6143 69 > > XX cord-005453-4057qib7 6143 70 0.75 0.75 CD cord-005453-4057qib7 6143 71 , , , cord-005453-4057qib7 6143 72 for for IN cord-005453-4057qib7 6143 73 Doppler Doppler NNP cord-005453-4057qib7 6143 74 - - HYPH cord-005453-4057qib7 6143 75 US US NNP cord-005453-4057qib7 6143 76 . . . cord-005453-4057qib7 6144 1 Inflammatory inflammatory JJ cord-005453-4057qib7 6144 2 activity activity NN cord-005453-4057qib7 6144 3 was be VBD cord-005453-4057qib7 6144 4 classified classify VBN cord-005453-4057qib7 6144 5 as as IN cord-005453-4057qib7 6144 6 mild mild JJ cord-005453-4057qib7 6144 7 , , , cord-005453-4057qib7 6144 8 moderate moderate JJ cord-005453-4057qib7 6144 9 and and CC cord-005453-4057qib7 6144 10 severe severe JJ cord-005453-4057qib7 6144 11 according accord VBG cord-005453-4057qib7 6144 12 to to IN cord-005453-4057qib7 6144 13 the the DT cord-005453-4057qib7 6144 14 severity severity NN cord-005453-4057qib7 6144 15 of of IN cord-005453-4057qib7 6144 16 Doppler Doppler NNP cord-005453-4057qib7 6144 17 - - HYPH cord-005453-4057qib7 6144 18 US US NNP cord-005453-4057qib7 6144 19 findings finding NNS cord-005453-4057qib7 6144 20 . . . cord-005453-4057qib7 6145 1 Results result NNS cord-005453-4057qib7 6145 2 : : : cord-005453-4057qib7 6146 1 HFSU HFSU NNP cord-005453-4057qib7 6146 2 showed show VBD cord-005453-4057qib7 6146 3 abnormal abnormal JJ cord-005453-4057qib7 6146 4 findings finding NNS cord-005453-4057qib7 6146 5 in in IN cord-005453-4057qib7 6146 6 all all DT cord-005453-4057qib7 6146 7 patients patient NNS cord-005453-4057qib7 6146 8 at at IN cord-005453-4057qib7 6146 9 diagnosis diagnosis NN cord-005453-4057qib7 6146 10 with with IN cord-005453-4057qib7 6146 11 no no DT cord-005453-4057qib7 6146 12 changes change NNS cord-005453-4057qib7 6146 13 except except IN cord-005453-4057qib7 6146 14 in in IN cord-005453-4057qib7 6146 15 two two CD cord-005453-4057qib7 6146 16 patients patient NNS cord-005453-4057qib7 6146 17 along along IN cord-005453-4057qib7 6146 18 the the DT cord-005453-4057qib7 6146 19 treatment treatment NN cord-005453-4057qib7 6146 20 follow follow NN cord-005453-4057qib7 6146 21 - - HYPH cord-005453-4057qib7 6146 22 up up NN cord-005453-4057qib7 6146 23 . . . cord-005453-4057qib7 6147 1 Inflammatory inflammatory JJ cord-005453-4057qib7 6147 2 activity activity NN cord-005453-4057qib7 6147 3 by by IN cord-005453-4057qib7 6147 4 Doppler Doppler NNP cord-005453-4057qib7 6147 5 - - HYPH cord-005453-4057qib7 6147 6 US US NNP cord-005453-4057qib7 6147 7 was be VBD cord-005453-4057qib7 6147 8 observed observe VBN cord-005453-4057qib7 6147 9 in in IN cord-005453-4057qib7 6147 10 5/6 5/6 CD cord-005453-4057qib7 6147 11 patients patient NNS cord-005453-4057qib7 6147 12 at at IN cord-005453-4057qib7 6147 13 diagnosis diagnosis NN cord-005453-4057qib7 6147 14 ( ( -LRB- cord-005453-4057qib7 6147 15 1 1 CD cord-005453-4057qib7 6147 16 mild mild JJ cord-005453-4057qib7 6147 17 , , , cord-005453-4057qib7 6147 18 3 3 CD cord-005453-4057qib7 6147 19 moderate moderate JJ cord-005453-4057qib7 6147 20 , , , cord-005453-4057qib7 6147 21 1 1 CD cord-005453-4057qib7 6147 22 severe severe NN cord-005453-4057qib7 6147 23 ) ) -RRB- cord-005453-4057qib7 6147 24 . . . cord-005453-4057qib7 6148 1 Four four CD cord-005453-4057qib7 6148 2 patients patient NNS cord-005453-4057qib7 6148 3 responded respond VBD cord-005453-4057qib7 6148 4 to to IN cord-005453-4057qib7 6148 5 treatment treatment NN cord-005453-4057qib7 6148 6 ( ( -LRB- cord-005453-4057qib7 6148 7 2 2 CD cord-005453-4057qib7 6148 8 complete complete JJ cord-005453-4057qib7 6148 9 responses response NNS cord-005453-4057qib7 6148 10 , , , cord-005453-4057qib7 6148 11 CR CR NNP cord-005453-4057qib7 6148 12 , , , cord-005453-4057qib7 6148 13 and and CC cord-005453-4057qib7 6148 14 2 2 CD cord-005453-4057qib7 6148 15 partial partial JJ cord-005453-4057qib7 6148 16 responses response NNS cord-005453-4057qib7 6148 17 , , , cord-005453-4057qib7 6148 18 PR PR NNP cord-005453-4057qib7 6148 19 ) ) -RRB- cord-005453-4057qib7 6148 20 , , , cord-005453-4057qib7 6148 21 one one CD cord-005453-4057qib7 6148 22 presented present VBD cord-005453-4057qib7 6148 23 clinical clinical JJ cord-005453-4057qib7 6148 24 improvement improvement NN cord-005453-4057qib7 6148 25 less less JJR cord-005453-4057qib7 6148 26 than than IN cord-005453-4057qib7 6148 27 PR PR NNP cord-005453-4057qib7 6148 28 , , , cord-005453-4057qib7 6148 29 and and CC cord-005453-4057qib7 6148 30 one one CD cord-005453-4057qib7 6148 31 , , , cord-005453-4057qib7 6148 32 progressive progressive JJ cord-005453-4057qib7 6148 33 disease disease NN cord-005453-4057qib7 6148 34 . . . cord-005453-4057qib7 6149 1 All all DT cord-005453-4057qib7 6149 2 patients patient NNS cord-005453-4057qib7 6149 3 with with IN cord-005453-4057qib7 6149 4 clinical clinical JJ cord-005453-4057qib7 6149 5 response response NN cord-005453-4057qib7 6149 6 had have VBD cord-005453-4057qib7 6149 7 also also RB cord-005453-4057qib7 6149 8 a a DT cord-005453-4057qib7 6149 9 P p NN cord-005453-4057qib7 6149 10 - - HYPH cord-005453-4057qib7 6149 11 ROM rom NN cord-005453-4057qib7 6149 12 improvement improvement NN cord-005453-4057qib7 6149 13 or or CC cord-005453-4057qib7 6149 14 normalization normalization NN cord-005453-4057qib7 6149 15 . . . cord-005453-4057qib7 6150 1 All all DT cord-005453-4057qib7 6150 2 patients patient NNS cord-005453-4057qib7 6150 3 achieving achieve VBG cord-005453-4057qib7 6150 4 a a DT cord-005453-4057qib7 6150 5 response response NN cord-005453-4057qib7 6150 6 showed show VBD cord-005453-4057qib7 6150 7 normalization normalization NN cord-005453-4057qib7 6150 8 ( ( -LRB- cord-005453-4057qib7 6150 9 n=2 n=2 NNS cord-005453-4057qib7 6150 10 ) ) -RRB- cord-005453-4057qib7 6150 11 or or CC cord-005453-4057qib7 6150 12 improvement improvement NN cord-005453-4057qib7 6150 13 ( ( -LRB- cord-005453-4057qib7 6150 14 n=2 n=2 NNS cord-005453-4057qib7 6150 15 ) ) -RRB- cord-005453-4057qib7 6150 16 of of IN cord-005453-4057qib7 6150 17 Doppler Doppler NNP cord-005453-4057qib7 6150 18 - - HYPH cord-005453-4057qib7 6150 19 US US NNP cord-005453-4057qib7 6150 20 findings finding NNS cord-005453-4057qib7 6150 21 . . . cord-005453-4057qib7 6151 1 The the DT cord-005453-4057qib7 6151 2 patient patient NN cord-005453-4057qib7 6151 3 with with IN cord-005453-4057qib7 6151 4 clinical clinical JJ cord-005453-4057qib7 6151 5 improvement improvement NN cord-005453-4057qib7 6151 6 less less JJR cord-005453-4057qib7 6151 7 than than IN cord-005453-4057qib7 6151 8 PR PR NNP cord-005453-4057qib7 6151 9 and and CC cord-005453-4057qib7 6151 10 the the DT cord-005453-4057qib7 6151 11 patient patient NN cord-005453-4057qib7 6151 12 with with IN cord-005453-4057qib7 6151 13 progressive progressive JJ cord-005453-4057qib7 6151 14 disease disease NN cord-005453-4057qib7 6151 15 showed show VBD cord-005453-4057qib7 6151 16 persistence persistence NN cord-005453-4057qib7 6151 17 of of IN cord-005453-4057qib7 6151 18 inflammatory inflammatory JJ cord-005453-4057qib7 6151 19 Doppler Doppler NNP cord-005453-4057qib7 6151 20 - - HYPH cord-005453-4057qib7 6151 21 US US NNP cord-005453-4057qib7 6151 22 findings finding NNS cord-005453-4057qib7 6151 23 . . . cord-005453-4057qib7 6152 1 Most Most JJS cord-005453-4057qib7 6152 2 patients patient NNS cord-005453-4057qib7 6152 3 had have VBD cord-005453-4057qib7 6152 4 normal normal JJ cord-005453-4057qib7 6152 5 or or CC cord-005453-4057qib7 6152 6 light light JJ cord-005453-4057qib7 6152 7 increase increase NN cord-005453-4057qib7 6152 8 of of IN cord-005453-4057qib7 6152 9 pro pro JJ cord-005453-4057qib7 6152 10 - - JJ cord-005453-4057qib7 6152 11 collagen collagen JJ cord-005453-4057qib7 6152 12 levels level NNS cord-005453-4057qib7 6152 13 at at IN cord-005453-4057qib7 6152 14 diagnosis diagnosis NN cord-005453-4057qib7 6152 15 and and CC cord-005453-4057qib7 6152 16 no no DT cord-005453-4057qib7 6152 17 significant significant JJ cord-005453-4057qib7 6152 18 changes change NNS cord-005453-4057qib7 6152 19 were be VBD cord-005453-4057qib7 6152 20 observed observe VBN cord-005453-4057qib7 6152 21 during during IN cord-005453-4057qib7 6152 22 follow follow NN cord-005453-4057qib7 6152 23 - - HYPH cord-005453-4057qib7 6152 24 up up NN cord-005453-4057qib7 6152 25 . . . cord-005453-4057qib7 6153 1 Levels level NNS cord-005453-4057qib7 6153 2 of of IN cord-005453-4057qib7 6153 3 hyaluronic hyaluronic NN cord-005453-4057qib7 6153 4 acid acid NN cord-005453-4057qib7 6153 5 tended tend VBD cord-005453-4057qib7 6153 6 to to TO cord-005453-4057qib7 6153 7 be be VB cord-005453-4057qib7 6153 8 very very RB cord-005453-4057qib7 6153 9 high high JJ cord-005453-4057qib7 6153 10 in in IN cord-005453-4057qib7 6153 11 patients patient NNS cord-005453-4057qib7 6153 12 with with IN cord-005453-4057qib7 6153 13 progressive progressive JJ cord-005453-4057qib7 6153 14 scGVHD scGVHD NNP cord-005453-4057qib7 6153 15 ( ( -LRB- cord-005453-4057qib7 6153 16 patients patient NNS cord-005453-4057qib7 6153 17 2 2 CD cord-005453-4057qib7 6153 18 and and CC cord-005453-4057qib7 6153 19 5 5 CD cord-005453-4057qib7 6153 20 ) ) -RRB- cord-005453-4057qib7 6153 21 and and CC cord-005453-4057qib7 6153 22 tended tend VBD cord-005453-4057qib7 6153 23 to to TO cord-005453-4057qib7 6153 24 decrease decrease VB cord-005453-4057qib7 6153 25 or or CC cord-005453-4057qib7 6153 26 normalize normalize VB cord-005453-4057qib7 6153 27 in in IN cord-005453-4057qib7 6153 28 those those DT cord-005453-4057qib7 6153 29 who who WP cord-005453-4057qib7 6153 30 responded respond VBD cord-005453-4057qib7 6153 31 to to IN cord-005453-4057qib7 6153 32 therapy therapy NN cord-005453-4057qib7 6153 33 ( ( -LRB- cord-005453-4057qib7 6153 34 patients patient NNS cord-005453-4057qib7 6153 35 1 1 CD cord-005453-4057qib7 6153 36 , , , cord-005453-4057qib7 6153 37 2 2 CD cord-005453-4057qib7 6153 38 , , , cord-005453-4057qib7 6153 39 and and CC cord-005453-4057qib7 6153 40 3 3 CD cord-005453-4057qib7 6153 41 ) ) -RRB- cord-005453-4057qib7 6153 42 . . . cord-005453-4057qib7 6154 1 Conclusions conclusion NNS cord-005453-4057qib7 6154 2 : : : cord-005453-4057qib7 6155 1 In in IN cord-005453-4057qib7 6155 2 this this DT cord-005453-4057qib7 6155 3 exploratory exploratory JJ cord-005453-4057qib7 6155 4 study study NN cord-005453-4057qib7 6155 5 , , , cord-005453-4057qib7 6155 6 HFSU HFSU NNP cord-005453-4057qib7 6155 7 was be VBD cord-005453-4057qib7 6155 8 a a DT cord-005453-4057qib7 6155 9 reliable reliable JJ cord-005453-4057qib7 6155 10 method method NN cord-005453-4057qib7 6155 11 for for IN cord-005453-4057qib7 6155 12 evaluating evaluate VBG cord-005453-4057qib7 6155 13 sclerotic sclerotic JJ cord-005453-4057qib7 6155 14 skin skin NN cord-005453-4057qib7 6155 15 changes change NNS cord-005453-4057qib7 6155 16 in in IN cord-005453-4057qib7 6155 17 scGVHD scgvhd ADD cord-005453-4057qib7 6155 18 . . . cord-005453-4057qib7 6156 1 Doppler Doppler NNP cord-005453-4057qib7 6156 2 - - HYPH cord-005453-4057qib7 6156 3 US US NNP cord-005453-4057qib7 6156 4 showed show VBD cord-005453-4057qib7 6156 5 a a DT cord-005453-4057qib7 6156 6 good good JJ cord-005453-4057qib7 6156 7 correlation correlation NN cord-005453-4057qib7 6156 8 with with IN cord-005453-4057qib7 6156 9 disease disease NN cord-005453-4057qib7 6156 10 activity activity NN cord-005453-4057qib7 6156 11 and and CC cord-005453-4057qib7 6156 12 response response NN cord-005453-4057qib7 6156 13 to to IN cord-005453-4057qib7 6156 14 treatment treatment NN cord-005453-4057qib7 6156 15 . . . cord-005453-4057qib7 6157 1 Serum serum NN cord-005453-4057qib7 6157 2 hyaluronic hyaluronic NN cord-005453-4057qib7 6157 3 acid acid NN cord-005453-4057qib7 6157 4 levels level NNS cord-005453-4057qib7 6157 5 might may MD cord-005453-4057qib7 6157 6 be be VB cord-005453-4057qib7 6157 7 a a DT cord-005453-4057qib7 6157 8 biomarker biomarker NN cord-005453-4057qib7 6157 9 of of IN cord-005453-4057qib7 6157 10 disease disease NN cord-005453-4057qib7 6157 11 activity activity NN cord-005453-4057qib7 6157 12 that that WDT cord-005453-4057qib7 6157 13 deserves deserve VBZ cord-005453-4057qib7 6157 14 further further JJ cord-005453-4057qib7 6157 15 investigation investigation NN cord-005453-4057qib7 6157 16 . . . cord-005453-4057qib7 6158 1 HFSU HFSU NNP cord-005453-4057qib7 6158 2 plus plus CC cord-005453-4057qib7 6158 3 Doppler Doppler NNP cord-005453-4057qib7 6158 4 - - HYPH cord-005453-4057qib7 6158 5 US US NNP cord-005453-4057qib7 6158 6 is be VBZ cord-005453-4057qib7 6158 7 a a DT cord-005453-4057qib7 6158 8 useful useful JJ cord-005453-4057qib7 6158 9 , , , cord-005453-4057qib7 6158 10 non non JJ cord-005453-4057qib7 6158 11 - - JJ cord-005453-4057qib7 6158 12 invasive invasive JJ cord-005453-4057qib7 6158 13 , , , cord-005453-4057qib7 6158 14 repeatable repeatable JJ cord-005453-4057qib7 6158 15 device device NN cord-005453-4057qib7 6158 16 in in IN cord-005453-4057qib7 6158 17 monitoring monitor VBG cord-005453-4057qib7 6158 18 patients patient NNS cord-005453-4057qib7 6158 19 suffering suffer VBG cord-005453-4057qib7 6158 20 from from IN cord-005453-4057qib7 6158 21 scGVHD scgvhd ADD cord-005453-4057qib7 6158 22 . . . cord-005453-4057qib7 6159 1 According accord VBG cord-005453-4057qib7 6159 2 to to IN cord-005453-4057qib7 6159 3 our -PRON- PRP$ cord-005453-4057qib7 6159 4 results result NNS cord-005453-4057qib7 6159 5 , , , cord-005453-4057qib7 6159 6 Doppler Doppler NNP cord-005453-4057qib7 6159 7 - - HYPH cord-005453-4057qib7 6159 8 US US NNP cord-005453-4057qib7 6159 9 may may MD cord-005453-4057qib7 6159 10 be be VB cord-005453-4057qib7 6159 11 a a DT cord-005453-4057qib7 6159 12 more more RBR cord-005453-4057qib7 6159 13 sensitive sensitive JJ cord-005453-4057qib7 6159 14 parameter parameter NN cord-005453-4057qib7 6159 15 than than IN cord-005453-4057qib7 6159 16 HFSU HFSU NNP cord-005453-4057qib7 6159 17 in in IN cord-005453-4057qib7 6159 18 assessment assessment NN cord-005453-4057qib7 6159 19 inflammatory inflammatory JJ cord-005453-4057qib7 6159 20 activity activity NN cord-005453-4057qib7 6159 21 of of IN cord-005453-4057qib7 6159 22 scGVHD scgvhd ADD cord-005453-4057qib7 6159 23 . . . cord-005453-4057qib7 6160 1 Disclosure disclosure NN cord-005453-4057qib7 6160 2 : : : cord-005453-4057qib7 6161 1 María María NNP cord-005453-4057qib7 6161 2 Suárez Suárez NNP cord-005453-4057qib7 6161 3 - - HYPH cord-005453-4057qib7 6161 4 Lledó Lledó NNP cord-005453-4057qib7 6161 5 received receive VBD cord-005453-4057qib7 6161 6 a a DT cord-005453-4057qib7 6161 7 grant grant NN cord-005453-4057qib7 6161 8 from from IN cord-005453-4057qib7 6161 9 DKMS DKMS NNP cord-005453-4057qib7 6161 10 - - HYPH cord-005453-4057qib7 6161 11 Spain Spain NNP cord-005453-4057qib7 6161 12 Foundation Foundation NNP cord-005453-4057qib7 6161 13 . . . cord-005453-4057qib7 6162 1 Other other JJ cord-005453-4057qib7 6162 2 authors author NNS cord-005453-4057qib7 6162 3 have have VBP cord-005453-4057qib7 6162 4 Nothing nothing NN cord-005453-4057qib7 6162 5 to to TO cord-005453-4057qib7 6162 6 declare declare VB cord-005453-4057qib7 6162 7 Post Post NNP cord-005453-4057qib7 6162 8 - - JJ cord-005453-4057qib7 6162 9 transplant transplant NN cord-005453-4057qib7 6162 10 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 6162 11 versus versus IN cord-005453-4057qib7 6162 12 antithymocyte antithymocyte NN cord-005453-4057qib7 6162 13 - - HYPH cord-005453-4057qib7 6162 14 globulin globulin NN cord-005453-4057qib7 6162 15 in in IN cord-005453-4057qib7 6162 16 HLA HLA NNP cord-005453-4057qib7 6162 17 - - HYPH cord-005453-4057qib7 6162 18 matched match VBN cord-005453-4057qib7 6162 19 unrelated unrelated JJ cord-005453-4057qib7 6162 20 and and CC cord-005453-4057qib7 6162 21 haploidentical haploidentical JJ cord-005453-4057qib7 6162 22 transplantation transplantation NN cord-005453-4057qib7 6162 23 for for IN cord-005453-4057qib7 6162 24 hematologic hematologic JJ cord-005453-4057qib7 6162 25 malignancies malignancy NNS cord-005453-4057qib7 6162 26 Background background NN cord-005453-4057qib7 6162 27 : : : cord-005453-4057qib7 6162 28 Post post JJ cord-005453-4057qib7 6162 29 - - NN cord-005453-4057qib7 6162 30 transplant transplant NN cord-005453-4057qib7 6162 31 cyclophosphamide(PTCy cyclophosphamide(ptcy NN cord-005453-4057qib7 6162 32 ) ) -RRB- cord-005453-4057qib7 6162 33 and and CC cord-005453-4057qib7 6162 34 antithymocyte antithymocyte RB cord-005453-4057qib7 6162 35 - - HYPH cord-005453-4057qib7 6162 36 globulin(ATG globulin(ATG NNP cord-005453-4057qib7 6162 37 ) ) -RRB- cord-005453-4057qib7 6162 38 are be VBP cord-005453-4057qib7 6162 39 the the DT cord-005453-4057qib7 6162 40 most most RBS cord-005453-4057qib7 6162 41 commonly commonly RB cord-005453-4057qib7 6162 42 used use VBN cord-005453-4057qib7 6162 43 regimens regimen NNS cord-005453-4057qib7 6162 44 for for IN cord-005453-4057qib7 6162 45 the the DT cord-005453-4057qib7 6162 46 prophylaxis prophylaxis NN cord-005453-4057qib7 6162 47 of of IN cord-005453-4057qib7 6162 48 graft graft NN cord-005453-4057qib7 6162 49 - - HYPH cord-005453-4057qib7 6162 50 versus versus NN cord-005453-4057qib7 6162 51 host host NN cord-005453-4057qib7 6162 52 disease(GVHD disease(gvhd ADD cord-005453-4057qib7 6162 53 ) ) -RRB- cord-005453-4057qib7 6162 54 . . . cord-005453-4057qib7 6163 1 We -PRON- PRP cord-005453-4057qib7 6163 2 compared compare VBD cord-005453-4057qib7 6163 3 these these DT cord-005453-4057qib7 6163 4 two two CD cord-005453-4057qib7 6163 5 regimens regimen NNS cord-005453-4057qib7 6163 6 in in IN cord-005453-4057qib7 6163 7 HLAmatched hlamatched JJ cord-005453-4057qib7 6163 8 unrelated unrelated JJ cord-005453-4057qib7 6163 9 ( ( -LRB- cord-005453-4057qib7 6163 10 MUD mud NN cord-005453-4057qib7 6163 11 ) ) -RRB- cord-005453-4057qib7 6163 12 and and CC cord-005453-4057qib7 6163 13 haploidentical haploidentical JJ cord-005453-4057qib7 6163 14 transplantation transplantation NN cord-005453-4057qib7 6163 15 for for IN cord-005453-4057qib7 6163 16 hematologic hematologic JJ cord-005453-4057qib7 6163 17 malignancies malignancy NNS cord-005453-4057qib7 6163 18 . . . cord-005453-4057qib7 6164 1 Methods method NNS cord-005453-4057qib7 6164 2 : : : cord-005453-4057qib7 6164 3 We -PRON- PRP cord-005453-4057qib7 6164 4 retrospectively retrospectively RB cord-005453-4057qib7 6164 5 analyzed analyze VBD cord-005453-4057qib7 6164 6 the the DT cord-005453-4057qib7 6164 7 consecutive consecutive JJ cord-005453-4057qib7 6164 8 adult adult NN cord-005453-4057qib7 6164 9 patients patient NNS cord-005453-4057qib7 6164 10 with with IN cord-005453-4057qib7 6164 11 hematologic hematologic JJ cord-005453-4057qib7 6164 12 malignancies malignancy NNS cord-005453-4057qib7 6164 13 who who WP cord-005453-4057qib7 6164 14 received receive VBD cord-005453-4057qib7 6164 15 MUD MUD NNP cord-005453-4057qib7 6164 16 and and CC cord-005453-4057qib7 6164 17 haploidentical haploidentical JJ cord-005453-4057qib7 6164 18 transplantation transplantation NN cord-005453-4057qib7 6164 19 at at IN cord-005453-4057qib7 6164 20 Chungnam Chungnam NNP cord-005453-4057qib7 6164 21 National National NNP cord-005453-4057qib7 6164 22 University University NNP cord-005453-4057qib7 6164 23 Hospital Hospital NNP cord-005453-4057qib7 6164 24 between between IN cord-005453-4057qib7 6164 25 January January NNP cord-005453-4057qib7 6164 26 2013 2013 CD cord-005453-4057qib7 6164 27 and and CC cord-005453-4057qib7 6164 28 January January NNP cord-005453-4057qib7 6164 29 2018 2018 CD cord-005453-4057qib7 6164 30 . . . cord-005453-4057qib7 6165 1 Patients patient NNS cord-005453-4057qib7 6165 2 who who WP cord-005453-4057qib7 6165 3 received receive VBD cord-005453-4057qib7 6165 4 second second JJ cord-005453-4057qib7 6165 5 transplantation transplantation NN cord-005453-4057qib7 6165 6 and and CC cord-005453-4057qib7 6165 7 had have VBD cord-005453-4057qib7 6165 8 refractory refractory JJ cord-005453-4057qib7 6165 9 disease disease NN cord-005453-4057qib7 6165 10 were be VBD cord-005453-4057qib7 6165 11 excluded exclude VBN cord-005453-4057qib7 6165 12 . . . cord-005453-4057qib7 6166 1 Results result NNS cord-005453-4057qib7 6166 2 : : : cord-005453-4057qib7 6167 1 This this DT cord-005453-4057qib7 6167 2 study study NN cord-005453-4057qib7 6167 3 included include VBD cord-005453-4057qib7 6167 4 45 45 CD cord-005453-4057qib7 6167 5 patients patient NNS cord-005453-4057qib7 6167 6 with with IN cord-005453-4057qib7 6167 7 median median JJ cord-005453-4057qib7 6167 8 age age NN cord-005453-4057qib7 6167 9 of of IN cord-005453-4057qib7 6167 10 54 54 CD cord-005453-4057qib7 6168 1 ( ( -LRB- cord-005453-4057qib7 6168 2 range range NN cord-005453-4057qib7 6168 3 , , , cord-005453-4057qib7 6168 4 18 18 CD cord-005453-4057qib7 6168 5 - - SYM cord-005453-4057qib7 6168 6 71 71 CD cord-005453-4057qib7 6168 7 ) ) -RRB- cord-005453-4057qib7 6168 8 years year NNS cord-005453-4057qib7 6168 9 : : : cord-005453-4057qib7 6168 10 29 29 CD cord-005453-4057qib7 6168 11 ( ( -LRB- cord-005453-4057qib7 6168 12 64.4 64.4 CD cord-005453-4057qib7 6168 13 % % NN cord-005453-4057qib7 6168 14 ) ) -RRB- cord-005453-4057qib7 6169 1 patients patient NNS cord-005453-4057qib7 6169 2 received receive VBD cord-005453-4057qib7 6169 3 MUD mud NN cord-005453-4057qib7 6169 4 transplant transplant NN cord-005453-4057qib7 6169 5 ( ( -LRB- cord-005453-4057qib7 6169 6 8 8 CD cord-005453-4057qib7 6169 7 and and CC cord-005453-4057qib7 6169 8 21 21 CD cord-005453-4057qib7 6169 9 patients patient NNS cord-005453-4057qib7 6169 10 in in IN cord-005453-4057qib7 6169 11 PTCy PTCy NNS cord-005453-4057qib7 6169 12 and and CC cord-005453-4057qib7 6169 13 ATG ATG NNP cord-005453-4057qib7 6169 14 group group NN cord-005453-4057qib7 6169 15 , , , cord-005453-4057qib7 6169 16 respectively respectively RB cord-005453-4057qib7 6169 17 ) ) -RRB- cord-005453-4057qib7 6169 18 , , , cord-005453-4057qib7 6169 19 and and CC cord-005453-4057qib7 6169 20 16 16 CD cord-005453-4057qib7 6169 21 ( ( -LRB- cord-005453-4057qib7 6169 22 35.6 35.6 CD cord-005453-4057qib7 6169 23 % % NN cord-005453-4057qib7 6169 24 ) ) -RRB- cord-005453-4057qib7 6170 1 patients patient NNS cord-005453-4057qib7 6170 2 received receive VBD cord-005453-4057qib7 6170 3 haploidentical haploidentical JJ cord-005453-4057qib7 6170 4 transplant transplant NN cord-005453-4057qib7 6170 5 ( ( -LRB- cord-005453-4057qib7 6170 6 11 11 CD cord-005453-4057qib7 6170 7 and and CC cord-005453-4057qib7 6170 8 5 5 CD cord-005453-4057qib7 6170 9 patients patient NNS cord-005453-4057qib7 6170 10 in in IN cord-005453-4057qib7 6170 11 PTCy PTCy NNS cord-005453-4057qib7 6170 12 and and CC cord-005453-4057qib7 6170 13 ATG ATG NNP cord-005453-4057qib7 6170 14 group group NN cord-005453-4057qib7 6170 15 ) ) -RRB- cord-005453-4057qib7 6170 16 . . . cord-005453-4057qib7 6171 1 Graft graft NN cord-005453-4057qib7 6171 2 source source NN cord-005453-4057qib7 6171 3 was be VBD cord-005453-4057qib7 6171 4 peripheral peripheral JJ cord-005453-4057qib7 6171 5 blood blood NN cord-005453-4057qib7 6171 6 stem stem NN cord-005453-4057qib7 6171 7 cell cell NN cord-005453-4057qib7 6171 8 in in IN cord-005453-4057qib7 6171 9 all all DT cord-005453-4057qib7 6171 10 patients patient NNS cord-005453-4057qib7 6171 11 . . . cord-005453-4057qib7 6172 1 Median median JJ cord-005453-4057qib7 6172 2 follow follow NN cord-005453-4057qib7 6172 3 - - HYPH cord-005453-4057qib7 6172 4 up up RP cord-005453-4057qib7 6172 5 duration duration NN cord-005453-4057qib7 6172 6 was be VBD cord-005453-4057qib7 6172 7 15.5 15.5 CD cord-005453-4057qib7 6172 8 months month NNS cord-005453-4057qib7 6173 1 ( ( -LRB- cord-005453-4057qib7 6173 2 range range NN cord-005453-4057qib7 6173 3 , , , cord-005453-4057qib7 6173 4 0.5 0.5 CD cord-005453-4057qib7 6173 5 - - HYPH cord-005453-4057qib7 6173 6 58.0 58.0 CD cord-005453-4057qib7 6173 7 ) ) -RRB- cord-005453-4057qib7 6173 8 . . . cord-005453-4057qib7 6174 1 In in IN cord-005453-4057qib7 6174 2 MUD mud NN cord-005453-4057qib7 6174 3 transplant transplant NN cord-005453-4057qib7 6174 4 , , , cord-005453-4057qib7 6174 5 the the DT cord-005453-4057qib7 6174 6 estimated estimate VBN cord-005453-4057qib7 6174 7 20-months 20-months CD cord-005453-4057qib7 6174 8 survival survival NN cord-005453-4057qib7 6174 9 rate rate NN cord-005453-4057qib7 6174 10 were be VBD cord-005453-4057qib7 6174 11 85.7 85.7 CD cord-005453-4057qib7 6174 12 % % NN cord-005453-4057qib7 6174 13 in in IN cord-005453-4057qib7 6174 14 PTCy PTCy NNS cord-005453-4057qib7 6174 15 vs. vs. CC cord-005453-4057qib7 6174 16 80.7 80.7 CD cord-005453-4057qib7 6174 17 % % NN cord-005453-4057qib7 6174 18 in in IN cord-005453-4057qib7 6174 19 ATG ATG NNP cord-005453-4057qib7 6174 20 ( ( -LRB- cord-005453-4057qib7 6174 21 p=0.835 p=0.835 NNP cord-005453-4057qib7 6174 22 ) ) -RRB- cord-005453-4057qib7 6174 23 , , , cord-005453-4057qib7 6174 24 the the DT cord-005453-4057qib7 6174 25 20-months 20-months CD cord-005453-4057qib7 6174 26 relapse relapse NN cord-005453-4057qib7 6174 27 rate rate NN cord-005453-4057qib7 6174 28 were be VBD cord-005453-4057qib7 6174 29 37.5 37.5 CD cord-005453-4057qib7 6174 30 % % NN cord-005453-4057qib7 6174 31 in in IN cord-005453-4057qib7 6174 32 PTCy PTCy NNS cord-005453-4057qib7 6174 33 vs. vs. CC cord-005453-4057qib7 6174 34 35.0 35.0 CD cord-005453-4057qib7 6174 35 % % NN cord-005453-4057qib7 6174 36 in in IN cord-005453-4057qib7 6174 37 ATG ATG NNP cord-005453-4057qib7 6174 38 ( ( -LRB- cord-005453-4057qib7 6174 39 p=0.663 p=0.663 NNP cord-005453-4057qib7 6174 40 ) ) -RRB- cord-005453-4057qib7 6174 41 , , , cord-005453-4057qib7 6174 42 the the DT cord-005453-4057qib7 6174 43 cumulative cumulative JJ cord-005453-4057qib7 6174 44 incidence incidence NN cord-005453-4057qib7 6174 45 of of IN cord-005453-4057qib7 6174 46 grade grade NN cord-005453-4057qib7 6174 47 2 2 CD cord-005453-4057qib7 6174 48 to to TO cord-005453-4057qib7 6174 49 4 4 CD cord-005453-4057qib7 6174 50 acute acute JJ cord-005453-4057qib7 6174 51 GVHD GVHD NNP cord-005453-4057qib7 6174 52 were be VBD cord-005453-4057qib7 6174 53 25.0 25.0 CD cord-005453-4057qib7 6174 54 % % NN cord-005453-4057qib7 6174 55 in in IN cord-005453-4057qib7 6174 56 PTCy PTCy NNS cord-005453-4057qib7 6174 57 vs. vs. CC cord-005453-4057qib7 6174 58 22.2 22.2 CD cord-005453-4057qib7 6174 59 % % NN cord-005453-4057qib7 6174 60 in in IN cord-005453-4057qib7 6174 61 ATG ATG NNP cord-005453-4057qib7 6174 62 ( ( -LRB- cord-005453-4057qib7 6174 63 p=0.706 p=0.706 NNP cord-005453-4057qib7 6174 64 ) ) -RRB- cord-005453-4057qib7 6174 65 , , , cord-005453-4057qib7 6174 66 and and CC cord-005453-4057qib7 6174 67 the the DT cord-005453-4057qib7 6174 68 estimated estimate VBN cord-005453-4057qib7 6174 69 20-month 20-month JJ cord-005453-4057qib7 6174 70 extensive extensive JJ cord-005453-4057qib7 6174 71 chronic chronic JJ cord-005453-4057qib7 6174 72 GVHD GVHD NNP cord-005453-4057qib7 6174 73 rate rate NN cord-005453-4057qib7 6174 74 were be VBD cord-005453-4057qib7 6174 75 25.0 25.0 CD cord-005453-4057qib7 6174 76 % % NN cord-005453-4057qib7 6174 77 in in IN cord-005453-4057qib7 6174 78 PTCy PTCy NNS cord-005453-4057qib7 6174 79 vs. vs. CC cord-005453-4057qib7 6174 80 16.7 16.7 CD cord-005453-4057qib7 6174 81 % % NN cord-005453-4057qib7 6174 82 in in IN cord-005453-4057qib7 6174 83 ATG ATG NNP cord-005453-4057qib7 6174 84 ( ( -LRB- cord-005453-4057qib7 6174 85 p=0.902 p=0.902 NNP cord-005453-4057qib7 6174 86 ) ) -RRB- cord-005453-4057qib7 6174 87 . . . cord-005453-4057qib7 6175 1 In in IN cord-005453-4057qib7 6175 2 haploidentical haploidentical JJ cord-005453-4057qib7 6175 3 transplant transplant NN cord-005453-4057qib7 6175 4 , , , cord-005453-4057qib7 6175 5 the the DT cord-005453-4057qib7 6175 6 estimated estimate VBN cord-005453-4057qib7 6175 7 20-months 20-months CD cord-005453-4057qib7 6175 8 survival survival NN cord-005453-4057qib7 6175 9 rate rate NN cord-005453-4057qib7 6175 10 were be VBD cord-005453-4057qib7 6175 11 55.4 55.4 CD cord-005453-4057qib7 6175 12 % % NN cord-005453-4057qib7 6175 13 in in IN cord-005453-4057qib7 6175 14 PTCy PTCy NNS cord-005453-4057qib7 6175 15 vs. vs. IN cord-005453-4057qib7 6175 16 40.0 40.0 CD cord-005453-4057qib7 6175 17 % % NN cord-005453-4057qib7 6175 18 in in IN cord-005453-4057qib7 6175 19 ATG ATG NNP cord-005453-4057qib7 6175 20 ( ( -LRB- cord-005453-4057qib7 6175 21 p=0.936 p=0.936 NNP cord-005453-4057qib7 6175 22 ) ) -RRB- cord-005453-4057qib7 6175 23 , , , cord-005453-4057qib7 6175 24 the the DT cord-005453-4057qib7 6175 25 20-months 20-months CD cord-005453-4057qib7 6175 26 relapse relapse NN cord-005453-4057qib7 6175 27 rate rate NN cord-005453-4057qib7 6175 28 were be VBD cord-005453-4057qib7 6175 29 42.9 42.9 CD cord-005453-4057qib7 6175 30 % % NN cord-005453-4057qib7 6175 31 in in IN cord-005453-4057qib7 6175 32 PTCy PTCy NNS cord-005453-4057qib7 6175 33 vs. vs. CC cord-005453-4057qib7 6175 34 33.3 33.3 CD cord-005453-4057qib7 6175 35 % % NN cord-005453-4057qib7 6175 36 in in IN cord-005453-4057qib7 6175 37 ATG ATG NNP cord-005453-4057qib7 6175 38 ( ( -LRB- cord-005453-4057qib7 6175 39 p=0.328 p=0.328 NNP cord-005453-4057qib7 6175 40 ) ) -RRB- cord-005453-4057qib7 6175 41 , , , cord-005453-4057qib7 6175 42 the the DT cord-005453-4057qib7 6175 43 cumulative cumulative JJ cord-005453-4057qib7 6175 44 incidence incidence NN cord-005453-4057qib7 6175 45 of of IN cord-005453-4057qib7 6175 46 grade grade NN cord-005453-4057qib7 6175 47 3 3 CD cord-005453-4057qib7 6175 48 to to TO cord-005453-4057qib7 6175 49 4 4 CD cord-005453-4057qib7 6175 50 acute acute JJ cord-005453-4057qib7 6175 51 GVHD GVHD NNP cord-005453-4057qib7 6175 52 rate rate NN cord-005453-4057qib7 6175 53 were be VBD cord-005453-4057qib7 6175 54 29.9 29.9 CD cord-005453-4057qib7 6175 55 % % NN cord-005453-4057qib7 6175 56 in in IN cord-005453-4057qib7 6175 57 PTCy PTCy NNS cord-005453-4057qib7 6175 58 vs. vs. CC cord-005453-4057qib7 6175 59 33.3 33.3 CD cord-005453-4057qib7 6175 60 % % NN cord-005453-4057qib7 6175 61 in in IN cord-005453-4057qib7 6175 62 ATG ATG NNP cord-005453-4057qib7 6175 63 ( ( -LRB- cord-005453-4057qib7 6175 64 p=0.686 p=0.686 NNP cord-005453-4057qib7 6175 65 ) ) -RRB- cord-005453-4057qib7 6175 66 , , , cord-005453-4057qib7 6175 67 and and CC cord-005453-4057qib7 6175 68 the the DT cord-005453-4057qib7 6175 69 estimated estimate VBN cord-005453-4057qib7 6175 70 12 12 CD cord-005453-4057qib7 6175 71 month month NN cord-005453-4057qib7 6175 72 extensive extensive JJ cord-005453-4057qib7 6175 73 chronic chronic JJ cord-005453-4057qib7 6175 74 GVHD GVHD NNP cord-005453-4057qib7 6175 75 rate rate NN cord-005453-4057qib7 6175 76 were be VBD cord-005453-4057qib7 6175 77 25.0 25.0 CD cord-005453-4057qib7 6175 78 % % NN cord-005453-4057qib7 6175 79 in in IN cord-005453-4057qib7 6175 80 PTCy PTCy NNS cord-005453-4057qib7 6175 81 vs. vs. IN cord-005453-4057qib7 6175 82 50.0 50.0 CD cord-005453-4057qib7 6175 83 % % NN cord-005453-4057qib7 6175 84 in in IN cord-005453-4057qib7 6175 85 ATG ATG NNP cord-005453-4057qib7 6175 86 ( ( -LRB- cord-005453-4057qib7 6175 87 p=0.575 p=0.575 VBG cord-005453-4057qib7 6175 88 ) ) -RRB- cord-005453-4057qib7 6175 89 . . . cord-005453-4057qib7 6176 1 Patients patient NNS cord-005453-4057qib7 6176 2 receiving receive VBG cord-005453-4057qib7 6176 3 PTCy PTCy NNS cord-005453-4057qib7 6176 4 had have VBD cord-005453-4057qib7 6176 5 significantly significantly RB cord-005453-4057qib7 6176 6 longer long JJR cord-005453-4057qib7 6176 7 neutrophil neutrophil NN cord-005453-4057qib7 6176 8 engraftment engraftment NN cord-005453-4057qib7 6176 9 time time NN cord-005453-4057qib7 6176 10 than than IN cord-005453-4057qib7 6176 11 those those DT cord-005453-4057qib7 6176 12 receiving receive VBG cord-005453-4057qib7 6176 13 ATG ATG NNP cord-005453-4057qib7 6176 14 in in IN cord-005453-4057qib7 6176 15 haploidentical haploidentical JJ cord-005453-4057qib7 6176 16 transplant transplant NN cord-005453-4057qib7 6176 17 [ [ -LRB- cord-005453-4057qib7 6176 18 median(range median(range NN cord-005453-4057qib7 6176 19 ) ) -RRB- cord-005453-4057qib7 6177 1 ; ; : cord-005453-4057qib7 6177 2 17.0(14.0 17.0(14.0 NNP cord-005453-4057qib7 6177 3 - - HYPH cord-005453-4057qib7 6177 4 21.0 21.0 CD cord-005453-4057qib7 6177 5 ) ) -RRB- cord-005453-4057qib7 6177 6 days day NNS cord-005453-4057qib7 6177 7 vs. vs. IN cord-005453-4057qib7 6177 8 14.0(13.0 14.0(13.0 NNP cord-005453-4057qib7 6177 9 - - HYPH cord-005453-4057qib7 6177 10 16.0 16.0 CD cord-005453-4057qib7 6177 11 ) ) -RRB- cord-005453-4057qib7 6177 12 days day NNS cord-005453-4057qib7 6177 13 , , , cord-005453-4057qib7 6177 14 p=0.005 p=0.005 NNP cord-005453-4057qib7 6177 15 ] ] -RRB- cord-005453-4057qib7 6177 16 . . . cord-005453-4057qib7 6178 1 Conclusions conclusion NNS cord-005453-4057qib7 6178 2 : : : cord-005453-4057qib7 6179 1 PTCy PTCy NNS cord-005453-4057qib7 6179 2 might may MD cord-005453-4057qib7 6179 3 be be VB cord-005453-4057qib7 6179 4 a a DT cord-005453-4057qib7 6179 5 good good JJ cord-005453-4057qib7 6179 6 option option NN cord-005453-4057qib7 6179 7 for for IN cord-005453-4057qib7 6179 8 the the DT cord-005453-4057qib7 6179 9 prophylaxis prophylaxis NN cord-005453-4057qib7 6179 10 of of IN cord-005453-4057qib7 6179 11 GVHD GVHD NNP cord-005453-4057qib7 6179 12 in in IN cord-005453-4057qib7 6179 13 HLA HLA NNP cord-005453-4057qib7 6179 14 - - HYPH cord-005453-4057qib7 6179 15 matched match VBN cord-005453-4057qib7 6179 16 unrelated unrelated JJ cord-005453-4057qib7 6179 17 transplant transplant NN cord-005453-4057qib7 6179 18 as as RB cord-005453-4057qib7 6179 19 well well RB cord-005453-4057qib7 6179 20 as as IN cord-005453-4057qib7 6179 21 haplo haplo NN cord-005453-4057qib7 6179 22 - - HYPH cord-005453-4057qib7 6179 23 identical identical JJ cord-005453-4057qib7 6179 24 transplant transplant NN cord-005453-4057qib7 6179 25 . . . cord-005453-4057qib7 6180 1 Disclosure disclosure NN cord-005453-4057qib7 6180 2 : : : cord-005453-4057qib7 6180 3 Nothing nothing NN cord-005453-4057qib7 6180 4 to to TO cord-005453-4057qib7 6180 5 declare declare VB cord-005453-4057qib7 6180 6 Early early JJ cord-005453-4057qib7 6180 7 fam fam JJ cord-005453-4057qib7 6180 8 therapy therapy NN cord-005453-4057qib7 6180 9 for for IN cord-005453-4057qib7 6180 10 post post FW cord-005453-4057qib7 6180 11 allo allo NNP cord-005453-4057qib7 6180 12 - - HYPH cord-005453-4057qib7 6180 13 HSCT HSCT NNP cord-005453-4057qib7 6180 14 bronchiolitis bronchiolitis NN cord-005453-4057qib7 6180 15 obliterans obliterans NNP cord-005453-4057qib7 6181 1 syndrome syndrome NN cord-005453-4057qib7 6181 2 Background Background NNP cord-005453-4057qib7 6181 3 : : : cord-005453-4057qib7 6182 1 bronchiolitis bronchiolitis NNP cord-005453-4057qib7 6182 2 obliterans obliterans NNP cord-005453-4057qib7 6182 3 syndrome syndrome NNP cord-005453-4057qib7 6182 4 ( ( -LRB- cord-005453-4057qib7 6182 5 BOS BOS NNP cord-005453-4057qib7 6182 6 ) ) -RRB- cord-005453-4057qib7 6182 7 is be VBZ cord-005453-4057qib7 6182 8 a a DT cord-005453-4057qib7 6182 9 potential potential JJ cord-005453-4057qib7 6182 10 major major JJ cord-005453-4057qib7 6182 11 complication complication NN cord-005453-4057qib7 6182 12 after after IN cord-005453-4057qib7 6182 13 allogeneic allogeneic JJ cord-005453-4057qib7 6182 14 hematopoietic hematopoietic JJ cord-005453-4057qib7 6182 15 stem stem NN cord-005453-4057qib7 6182 16 cell cell NN cord-005453-4057qib7 6182 17 transplantation transplantation NN cord-005453-4057qib7 6182 18 ( ( -LRB- cord-005453-4057qib7 6182 19 HSCT HSCT NNP cord-005453-4057qib7 6182 20 ) ) -RRB- cord-005453-4057qib7 6182 21 . . . cord-005453-4057qib7 6183 1 Attributed attribute VBN cord-005453-4057qib7 6183 2 to to IN cord-005453-4057qib7 6183 3 an an DT cord-005453-4057qib7 6183 4 allo allo NN cord-005453-4057qib7 6183 5 - - HYPH cord-005453-4057qib7 6183 6 immune immune JJ cord-005453-4057qib7 6183 7 reaction reaction NN cord-005453-4057qib7 6183 8 against against IN cord-005453-4057qib7 6183 9 the the DT cord-005453-4057qib7 6183 10 small small JJ cord-005453-4057qib7 6183 11 airways airway NNS cord-005453-4057qib7 6183 12 , , , cord-005453-4057qib7 6183 13 BO BO NNP cord-005453-4057qib7 6183 14 is be VBZ cord-005453-4057qib7 6183 15 considered consider VBN cord-005453-4057qib7 6183 16 a a DT cord-005453-4057qib7 6183 17 pulmonary pulmonary JJ cord-005453-4057qib7 6183 18 manifestation manifestation NN cord-005453-4057qib7 6183 19 of of IN cord-005453-4057qib7 6183 20 chronic chronic JJ cord-005453-4057qib7 6183 21 GVHD GVHD NNP cord-005453-4057qib7 6183 22 . . . cord-005453-4057qib7 6184 1 Reported report VBN cord-005453-4057qib7 6184 2 incidence incidence NN cord-005453-4057qib7 6184 3 of of IN cord-005453-4057qib7 6184 4 BOS BOS NNP cord-005453-4057qib7 6184 5 ranges range VBZ cord-005453-4057qib7 6184 6 from from IN cord-005453-4057qib7 6184 7 5 5 CD cord-005453-4057qib7 6184 8 to to TO cord-005453-4057qib7 6184 9 12 12 CD cord-005453-4057qib7 6184 10 % % NN cord-005453-4057qib7 6184 11 , , , cord-005453-4057qib7 6184 12 and and CC cord-005453-4057qib7 6184 13 BOS BOS NNP cord-005453-4057qib7 6184 14 - - HYPH cord-005453-4057qib7 6184 15 attributed attribute VBN cord-005453-4057qib7 6184 16 mortality mortality NN cord-005453-4057qib7 6184 17 as as RB cord-005453-4057qib7 6184 18 high high JJ cord-005453-4057qib7 6184 19 as as IN cord-005453-4057qib7 6184 20 30%-80 30%-80 CD cord-005453-4057qib7 6184 21 % % NN cord-005453-4057qib7 6184 22 . . . cord-005453-4057qib7 6185 1 A a DT cord-005453-4057qib7 6185 2 few few JJ cord-005453-4057qib7 6185 3 years year NNS cord-005453-4057qib7 6185 4 ago ago RB cord-005453-4057qib7 6185 5 , , , cord-005453-4057qib7 6185 6 a a DT cord-005453-4057qib7 6185 7 new new JJ cord-005453-4057qib7 6185 8 therapeutic therapeutic JJ cord-005453-4057qib7 6185 9 approach approach NN cord-005453-4057qib7 6185 10 with with IN cord-005453-4057qib7 6185 11 Fluticasone Fluticasone NNP cord-005453-4057qib7 6185 12 , , , cord-005453-4057qib7 6185 13 Azithromycin Azithromycin NNP cord-005453-4057qib7 6185 14 , , , cord-005453-4057qib7 6185 15 and and CC cord-005453-4057qib7 6185 16 Montelukast Montelukast NNP cord-005453-4057qib7 6185 17 ( ( -LRB- cord-005453-4057qib7 6185 18 FAM FAM NNP cord-005453-4057qib7 6185 19 ) ) -RRB- cord-005453-4057qib7 6185 20 was be VBD cord-005453-4057qib7 6185 21 described describe VBN cord-005453-4057qib7 6185 22 ( ( -LRB- cord-005453-4057qib7 6185 23 Norman Norman NNP cord-005453-4057qib7 6185 24 BC BC NNP cord-005453-4057qib7 6185 25 , , , cord-005453-4057qib7 6185 26 et et NNP cord-005453-4057qib7 6185 27 al al NNP cord-005453-4057qib7 6185 28 . . . cord-005453-4057qib7 6186 1 BMT BMT NNP cord-005453-4057qib7 6186 2 2011 2011 CD cord-005453-4057qib7 6186 3 ) ) -RRB- cord-005453-4057qib7 6186 4 . . . cord-005453-4057qib7 6187 1 Our -PRON- PRP$ cord-005453-4057qib7 6187 2 aim aim NN cord-005453-4057qib7 6187 3 was be VBD cord-005453-4057qib7 6187 4 to to TO cord-005453-4057qib7 6187 5 analyze analyze VB cord-005453-4057qib7 6187 6 the the DT cord-005453-4057qib7 6187 7 outcomes outcome NNS cord-005453-4057qib7 6187 8 of of IN cord-005453-4057qib7 6187 9 pts pt NNS cord-005453-4057qib7 6187 10 who who WP cord-005453-4057qib7 6187 11 developed develop VBD cord-005453-4057qib7 6187 12 BOS BOS NNP cord-005453-4057qib7 6187 13 and and CC cord-005453-4057qib7 6187 14 were be VBD cord-005453-4057qib7 6187 15 precociously precociously RB cord-005453-4057qib7 6187 16 treated treat VBN cord-005453-4057qib7 6187 17 with with IN cord-005453-4057qib7 6187 18 the the DT cord-005453-4057qib7 6187 19 FAM FAM NNP cord-005453-4057qib7 6187 20 scheme scheme NN cord-005453-4057qib7 6187 21 . . . cord-005453-4057qib7 6188 1 Methods method NNS cord-005453-4057qib7 6188 2 : : : cord-005453-4057qib7 6188 3 all all PDT cord-005453-4057qib7 6188 4 the the DT cord-005453-4057qib7 6188 5 209 209 CD cord-005453-4057qib7 6188 6 allo allo NN cord-005453-4057qib7 6188 7 - - HYPH cord-005453-4057qib7 6188 8 HSCT HSCT NNP cord-005453-4057qib7 6188 9 performed perform VBD cord-005453-4057qib7 6188 10 in in IN cord-005453-4057qib7 6188 11 our -PRON- PRP$ cord-005453-4057qib7 6188 12 center center NN cord-005453-4057qib7 6188 13 from from IN cord-005453-4057qib7 6188 14 January January NNP cord-005453-4057qib7 6188 15 2015 2015 CD cord-005453-4057qib7 6188 16 and and CC cord-005453-4057qib7 6188 17 July July NNP cord-005453-4057qib7 6188 18 2018 2018 CD cord-005453-4057qib7 6188 19 were be VBD cord-005453-4057qib7 6188 20 included include VBN cord-005453-4057qib7 6188 21 in in IN cord-005453-4057qib7 6188 22 the the DT cord-005453-4057qib7 6188 23 analysis analysis NN cord-005453-4057qib7 6188 24 . . . cord-005453-4057qib7 6189 1 Baseline baseline JJ cord-005453-4057qib7 6189 2 diseases disease NNS cord-005453-4057qib7 6189 3 were be VBD cord-005453-4057qib7 6189 4 : : : cord-005453-4057qib7 6189 5 69 69 CD cord-005453-4057qib7 6189 6 AML AML NNP cord-005453-4057qib7 6189 7 , , , cord-005453-4057qib7 6189 8 49 49 CD cord-005453-4057qib7 6189 9 LPD LPD NNP cord-005453-4057qib7 6189 10 , , , cord-005453-4057qib7 6189 11 31 31 CD cord-005453-4057qib7 6189 12 MDS MDS NNP cord-005453-4057qib7 6189 13 , , , cord-005453-4057qib7 6189 14 28 28 CD cord-005453-4057qib7 6189 15 ALL all DT cord-005453-4057qib7 6189 16 , , , cord-005453-4057qib7 6189 17 16 16 CD cord-005453-4057qib7 6189 18 MPD MPD NNP cord-005453-4057qib7 6189 19 , , , cord-005453-4057qib7 6189 20 10 10 CD cord-005453-4057qib7 6189 21 MM mm NN cord-005453-4057qib7 6189 22 , , , cord-005453-4057qib7 6189 23 and and CC cord-005453-4057qib7 6189 24 6 6 CD cord-005453-4057qib7 6189 25 BMF bmf NN cord-005453-4057qib7 6189 26 . . . cord-005453-4057qib7 6190 1 Day day NN cord-005453-4057qib7 6190 2 +100 +100 NNS cord-005453-4057qib7 6190 3 and and CC cord-005453-4057qib7 6190 4 day day NN cord-005453-4057qib7 6190 5 +365 +365 NNP cord-005453-4057qib7 6190 6 overall overall JJ cord-005453-4057qib7 6190 7 mortality mortality NN cord-005453-4057qib7 6190 8 were be VBD cord-005453-4057qib7 6190 9 9,1 9,1 CD cord-005453-4057qib7 6190 10 % % NN cord-005453-4057qib7 6190 11 and and CC cord-005453-4057qib7 6190 12 24,4 24,4 CD cord-005453-4057qib7 6190 13 % % NN cord-005453-4057qib7 6190 14 , , , cord-005453-4057qib7 6190 15 respectively respectively RB cord-005453-4057qib7 6190 16 . . . cord-005453-4057qib7 6191 1 Rest rest NN cord-005453-4057qib7 6191 2 of of IN cord-005453-4057qib7 6191 3 characteristics characteristic NNS cord-005453-4057qib7 6191 4 of of IN cord-005453-4057qib7 6191 5 the the DT cord-005453-4057qib7 6191 6 series series NN cord-005453-4057qib7 6191 7 are be VBP cord-005453-4057qib7 6191 8 shown show VBN cord-005453-4057qib7 6191 9 in in IN cord-005453-4057qib7 6191 10 table table NN cord-005453-4057qib7 6191 11 . . . cord-005453-4057qib7 6192 1 FAM FAM NNP cord-005453-4057qib7 6192 2 therapy therapy NN cord-005453-4057qib7 6192 3 was be VBD cord-005453-4057qib7 6192 4 systematically systematically RB cord-005453-4057qib7 6192 5 started start VBN cord-005453-4057qib7 6192 6 when when WRB cord-005453-4057qib7 6192 7 any any DT cord-005453-4057qib7 6192 8 patient patient NN cord-005453-4057qib7 6192 9 was be VBD cord-005453-4057qib7 6192 10 first first RB cord-005453-4057qib7 6192 11 diagnosed diagnose VBN cord-005453-4057qib7 6192 12 with with IN cord-005453-4057qib7 6192 13 BO BO NNP cord-005453-4057qib7 6192 14 . . . cord-005453-4057qib7 6193 1 Results result NNS cord-005453-4057qib7 6193 2 : : : cord-005453-4057qib7 6194 1 eleven eleven CD cord-005453-4057qib7 6194 2 patients patient NNS cord-005453-4057qib7 6194 3 ( ( -LRB- cord-005453-4057qib7 6194 4 5,3 5,3 CD cord-005453-4057qib7 6194 5 % % NN cord-005453-4057qib7 6194 6 ) ) -RRB- cord-005453-4057qib7 6194 7 were be VBD cord-005453-4057qib7 6194 8 diagnosed diagnose VBN cord-005453-4057qib7 6194 9 with with IN cord-005453-4057qib7 6194 10 BOS BOS NNP cord-005453-4057qib7 6194 11 . . . cord-005453-4057qib7 6195 1 At at IN cord-005453-4057qib7 6195 2 diagnosis diagnosis NN cord-005453-4057qib7 6195 3 of of IN cord-005453-4057qib7 6195 4 BOS BOS NNP cord-005453-4057qib7 6195 5 , , , cord-005453-4057qib7 6195 6 the the DT cord-005453-4057qib7 6195 7 pts pts NN cord-005453-4057qib7 6195 8 exhibited exhibit VBD cord-005453-4057qib7 6195 9 a a DT cord-005453-4057qib7 6195 10 FEV1 FEV1 NNP cord-005453-4057qib7 6195 11 80 80 CD cord-005453-4057qib7 6195 12 % % NN cord-005453-4057qib7 6195 13 of of IN cord-005453-4057qib7 6195 14 predicted predict VBN cord-005453-4057qib7 6195 15 ( ( -LRB- cord-005453-4057qib7 6195 16 median median JJ cord-005453-4057qib7 6195 17 FEV1 FEV1 NNP cord-005453-4057qib7 6195 18 : : : cord-005453-4057qib7 6195 19 74 74 CD cord-005453-4057qib7 6195 20 % % NN cord-005453-4057qib7 6195 21 ; ; : cord-005453-4057qib7 6195 22 range range NN cord-005453-4057qib7 6195 23 ; ; : cord-005453-4057qib7 6195 24 54 54 CD cord-005453-4057qib7 6195 25 - - SYM cord-005453-4057qib7 6195 26 86 86 CD cord-005453-4057qib7 6195 27 % % NN cord-005453-4057qib7 6195 28 ) ) -RRB- cord-005453-4057qib7 6196 1 and/or and/or CC cord-005453-4057qib7 6197 1 a a DT cord-005453-4057qib7 6197 2 decline decline NN cord-005453-4057qib7 6197 3 > > SYM cord-005453-4057qib7 6197 4 10 10 CD cord-005453-4057qib7 6197 5 % % NN cord-005453-4057qib7 6197 6 from from IN cord-005453-4057qib7 6197 7 pre pre JJ cord-005453-4057qib7 6197 8 - - JJ cord-005453-4057qib7 6197 9 HSCT HSCT NNP cord-005453-4057qib7 6197 10 . . . cord-005453-4057qib7 6198 1 At at IN cord-005453-4057qib7 6198 2 day day NN cord-005453-4057qib7 6198 3 +100 +100 NNS cord-005453-4057qib7 6198 4 , , , cord-005453-4057qib7 6198 5 6 6 CD cord-005453-4057qib7 6198 6 pts pt NNS cord-005453-4057qib7 6198 7 had have VBD cord-005453-4057qib7 6198 8 already already RB cord-005453-4057qib7 6198 9 the the DT cord-005453-4057qib7 6198 10 syndrome syndrome NN cord-005453-4057qib7 6198 11 . . . cord-005453-4057qib7 6199 1 Two two CD cord-005453-4057qib7 6199 2 of of IN cord-005453-4057qib7 6199 3 them -PRON- PRP cord-005453-4057qib7 6199 4 died die VBD cord-005453-4057qib7 6199 5 before before IN cord-005453-4057qib7 6199 6 the the DT cord-005453-4057qib7 6199 7 end end NN cord-005453-4057qib7 6199 8 of of IN cord-005453-4057qib7 6199 9 the the DT cord-005453-4057qib7 6199 10 first first JJ cord-005453-4057qib7 6199 11 year year NN cord-005453-4057qib7 6199 12 : : : cord-005453-4057qib7 6199 13 one one CD cord-005453-4057qib7 6199 14 due due IN cord-005453-4057qib7 6199 15 to to IN cord-005453-4057qib7 6199 16 invasive invasive JJ cord-005453-4057qib7 6199 17 zygomycosis zygomycosis NN cord-005453-4057qib7 6199 18 ( ( -LRB- cord-005453-4057qib7 6199 19 CNS CNS NNP cord-005453-4057qib7 6199 20 plus plus CC cord-005453-4057qib7 6199 21 pulmonary pulmonary JJ cord-005453-4057qib7 6199 22 ) ) -RRB- cord-005453-4057qib7 6199 23 and and CC cord-005453-4057qib7 6199 24 the the DT cord-005453-4057qib7 6199 25 other other JJ cord-005453-4057qib7 6199 26 to to IN cord-005453-4057qib7 6199 27 baseline baseline JJ cord-005453-4057qib7 6199 28 disease disease NN cord-005453-4057qib7 6199 29 progression progression NN cord-005453-4057qib7 6199 30 . . . cord-005453-4057qib7 6200 1 At at IN cord-005453-4057qib7 6200 2 day day NN cord-005453-4057qib7 6200 3 +365 +365 NNP cord-005453-4057qib7 6200 4 , , , cord-005453-4057qib7 6200 5 5 5 CD cord-005453-4057qib7 6200 6 more more JJR cord-005453-4057qib7 6200 7 pts pt NNS cord-005453-4057qib7 6200 8 had have VBD cord-005453-4057qib7 6200 9 BOS BOS NNP cord-005453-4057qib7 6200 10 . . . cord-005453-4057qib7 6201 1 Two two CD cord-005453-4057qib7 6201 2 more more JJR cord-005453-4057qib7 6201 3 pts pts NN cord-005453-4057qib7 6201 4 with with IN cord-005453-4057qib7 6201 5 BOS BOS NNP cord-005453-4057qib7 6201 6 died die VBD cord-005453-4057qib7 6201 7 at at IN cord-005453-4057qib7 6201 8 15 15 CD cord-005453-4057qib7 6201 9 and and CC cord-005453-4057qib7 6201 10 17 17 CD cord-005453-4057qib7 6201 11 months month NNS cord-005453-4057qib7 6201 12 post post JJ cord-005453-4057qib7 6201 13 - - JJ cord-005453-4057qib7 6201 14 HSCT HSCT NNP cord-005453-4057qib7 6201 15 due due IN cord-005453-4057qib7 6201 16 to to IN cord-005453-4057qib7 6201 17 baseline baseline JJ cord-005453-4057qib7 6201 18 disease disease NN cord-005453-4057qib7 6201 19 progression progression NN cord-005453-4057qib7 6201 20 . . . cord-005453-4057qib7 6202 1 At at IN cord-005453-4057qib7 6202 2 the the DT cord-005453-4057qib7 6202 3 close close NN cord-005453-4057qib7 6202 4 of of IN cord-005453-4057qib7 6202 5 the the DT cord-005453-4057qib7 6202 6 analysis analysis NN cord-005453-4057qib7 6202 7 , , , cord-005453-4057qib7 6202 8 7 7 CD cord-005453-4057qib7 6202 9 of of IN cord-005453-4057qib7 6202 10 the the DT cord-005453-4057qib7 6202 11 11 11 CD cord-005453-4057qib7 6202 12 pts pt NNS cord-005453-4057qib7 6202 13 were be VBD cord-005453-4057qib7 6202 14 alive alive JJ cord-005453-4057qib7 6202 15 . . . cord-005453-4057qib7 6203 1 So so RB cord-005453-4057qib7 6203 2 , , , cord-005453-4057qib7 6203 3 with with IN cord-005453-4057qib7 6203 4 a a DT cord-005453-4057qib7 6203 5 median median JJ cord-005453-4057qib7 6203 6 follow follow NN cord-005453-4057qib7 6203 7 - - HYPH cord-005453-4057qib7 6203 8 up up NN cord-005453-4057qib7 6203 9 of of IN cord-005453-4057qib7 6203 10 29 29 CD cord-005453-4057qib7 6203 11 months month NNS cord-005453-4057qib7 6203 12 ( ( -LRB- cord-005453-4057qib7 6203 13 range range NN cord-005453-4057qib7 6203 14 : : : cord-005453-4057qib7 6203 15 8 8 CD cord-005453-4057qib7 6203 16 - - SYM cord-005453-4057qib7 6203 17 44 44 CD cord-005453-4057qib7 6203 18 ) ) -RRB- cord-005453-4057qib7 6203 19 , , , cord-005453-4057qib7 6203 20 mortality mortality NN cord-005453-4057qib7 6203 21 and and CC cord-005453-4057qib7 6203 22 BOS BOS NNP cord-005453-4057qib7 6203 23 - - HYPH cord-005453-4057qib7 6203 24 attributable attributable JJ cord-005453-4057qib7 6203 25 mortality mortality NN cord-005453-4057qib7 6203 26 of of IN cord-005453-4057qib7 6203 27 the the DT cord-005453-4057qib7 6203 28 pts pts NN cord-005453-4057qib7 6203 29 with with IN cord-005453-4057qib7 6203 30 the the DT cord-005453-4057qib7 6203 31 complication complication NN cord-005453-4057qib7 6203 32 were be VBD cord-005453-4057qib7 6203 33 36,4 36,4 CD cord-005453-4057qib7 6203 34 % % NN cord-005453-4057qib7 6203 35 and and CC cord-005453-4057qib7 6203 36 9,1 9,1 CD cord-005453-4057qib7 6203 37 % % NN cord-005453-4057qib7 6203 38 , , , cord-005453-4057qib7 6203 39 respectively respectively RB cord-005453-4057qib7 6203 40 . . . cord-005453-4057qib7 6204 1 Conclusions conclusion NNS cord-005453-4057qib7 6204 2 : : : cord-005453-4057qib7 6205 1 1 1 LS cord-005453-4057qib7 6205 2 ) ) -RRB- cord-005453-4057qib7 6205 3 BOS BOS NNP cord-005453-4057qib7 6205 4 is be VBZ cord-005453-4057qib7 6205 5 an an DT cord-005453-4057qib7 6205 6 infrequent infrequent JJ cord-005453-4057qib7 6205 7 but but CC cord-005453-4057qib7 6205 8 very very RB cord-005453-4057qib7 6205 9 severe severe JJ cord-005453-4057qib7 6205 10 complication complication NN cord-005453-4057qib7 6205 11 of of IN cord-005453-4057qib7 6205 12 allo allo NN cord-005453-4057qib7 6205 13 - - HYPH cord-005453-4057qib7 6205 14 HSCT HSCT NNP cord-005453-4057qib7 6205 15 ; ; : cord-005453-4057qib7 6205 16 2 2 LS cord-005453-4057qib7 6205 17 ) ) -RRB- cord-005453-4057qib7 6205 18 BOS BOS NNP cord-005453-4057qib7 6205 19 seems seem VBZ cord-005453-4057qib7 6205 20 to to TO cord-005453-4057qib7 6205 21 be be VB cord-005453-4057qib7 6205 22 less less RBR cord-005453-4057qib7 6205 23 frequent frequent JJ cord-005453-4057qib7 6205 24 in in IN cord-005453-4057qib7 6205 25 pts pts NN cord-005453-4057qib7 6205 26 with with IN cord-005453-4057qib7 6205 27 prophylactic prophylactic JJ cord-005453-4057qib7 6205 28 pre pre JJ cord-005453-4057qib7 6205 29 - - JJ cord-005453-4057qib7 6205 30 transplant transplant JJ cord-005453-4057qib7 6205 31 rATG ratg JJ cord-005453-4057qib7 6205 32 or or CC cord-005453-4057qib7 6205 33 post post JJ cord-005453-4057qib7 6205 34 - - JJ cord-005453-4057qib7 6205 35 transplant transplant NN cord-005453-4057qib7 6205 36 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 6205 37 , , , cord-005453-4057qib7 6205 38 as as RB cord-005453-4057qib7 6205 39 well well RB cord-005453-4057qib7 6205 40 as as IN cord-005453-4057qib7 6205 41 in in IN cord-005453-4057qib7 6205 42 pts pts NN cord-005453-4057qib7 6205 43 undergoing undergo VBG cord-005453-4057qib7 6205 44 transplantation transplantation NN cord-005453-4057qib7 6205 45 with with IN cord-005453-4057qib7 6205 46 BM BM NNP cord-005453-4057qib7 6205 47 ( ( -LRB- cord-005453-4057qib7 6205 48 compared compare VBN cord-005453-4057qib7 6205 49 to to IN cord-005453-4057qib7 6205 50 PBSC PBSC NNP cord-005453-4057qib7 6205 51 ) ) -RRB- cord-005453-4057qib7 6205 52 . . . cord-005453-4057qib7 6206 1 3 3 LS cord-005453-4057qib7 6206 2 ) ) -RRB- cord-005453-4057qib7 6207 1 Early early JJ cord-005453-4057qib7 6207 2 diagnosis diagnosis NN cord-005453-4057qib7 6207 3 and and CC cord-005453-4057qib7 6207 4 therapy therapy NN cord-005453-4057qib7 6207 5 are be VBP cord-005453-4057qib7 6207 6 critical critical JJ cord-005453-4057qib7 6207 7 to to TO cord-005453-4057qib7 6207 8 minimize minimize VB cord-005453-4057qib7 6207 9 the the DT cord-005453-4057qib7 6207 10 BOS BOS NNP cord-005453-4057qib7 6207 11 - - HYPH cord-005453-4057qib7 6207 12 attributable attributable JJ cord-005453-4057qib7 6207 13 mortality mortality NN cord-005453-4057qib7 6207 14 . . . cord-005453-4057qib7 6208 1 Disclosure disclosure NN cord-005453-4057qib7 6208 2 Background background NN cord-005453-4057qib7 6208 3 : : : cord-005453-4057qib7 6208 4 Donor donor NN cord-005453-4057qib7 6208 5 lymphocyte lymphocyte NN cord-005453-4057qib7 6208 6 infusion infusion NN cord-005453-4057qib7 6208 7 ( ( -LRB- cord-005453-4057qib7 6208 8 DLI DLI NNP cord-005453-4057qib7 6208 9 ) ) -RRB- cord-005453-4057qib7 6208 10 is be VBZ cord-005453-4057qib7 6208 11 an an DT cord-005453-4057qib7 6208 12 established establish VBN cord-005453-4057qib7 6208 13 treatment treatment NN cord-005453-4057qib7 6208 14 for for IN cord-005453-4057qib7 6208 15 patients patient NNS cord-005453-4057qib7 6208 16 with with IN cord-005453-4057qib7 6208 17 hematological hematological JJ cord-005453-4057qib7 6208 18 malignancies malignancy NNS cord-005453-4057qib7 6208 19 relapsed relapse VBN cord-005453-4057qib7 6208 20 after after IN cord-005453-4057qib7 6208 21 allogeneic allogeneic JJ cord-005453-4057qib7 6208 22 hematopoietic hematopoietic JJ cord-005453-4057qib7 6208 23 stem stem NN cord-005453-4057qib7 6208 24 cell cell NN cord-005453-4057qib7 6208 25 transplantation transplantation NN cord-005453-4057qib7 6208 26 ( ( -LRB- cord-005453-4057qib7 6208 27 HSCT HSCT NNP cord-005453-4057qib7 6208 28 ) ) -RRB- cord-005453-4057qib7 6208 29 . . . cord-005453-4057qib7 6209 1 However however RB cord-005453-4057qib7 6209 2 , , , cord-005453-4057qib7 6209 3 it -PRON- PRP cord-005453-4057qib7 6209 4 is be VBZ cord-005453-4057qib7 6209 5 associated associate VBN cord-005453-4057qib7 6209 6 with with IN cord-005453-4057qib7 6209 7 an an DT cord-005453-4057qib7 6209 8 increased increase VBN cord-005453-4057qib7 6209 9 risk risk NN cord-005453-4057qib7 6209 10 of of IN cord-005453-4057qib7 6209 11 graft graft NN cord-005453-4057qib7 6209 12 - - HYPH cord-005453-4057qib7 6209 13 versus versus IN cord-005453-4057qib7 6209 14 - - HYPH cord-005453-4057qib7 6209 15 host host NN cord-005453-4057qib7 6209 16 disease disease NN cord-005453-4057qib7 6209 17 ( ( -LRB- cord-005453-4057qib7 6209 18 GVHD GVHD NNP cord-005453-4057qib7 6209 19 ) ) -RRB- cord-005453-4057qib7 6209 20 and and CC cord-005453-4057qib7 6209 21 modest modest JJ cord-005453-4057qib7 6209 22 anti anti JJ cord-005453-4057qib7 6209 23 - - JJ cord-005453-4057qib7 6209 24 tumor tumor JJ cord-005453-4057qib7 6209 25 activity activity NN cord-005453-4057qib7 6209 26 . . . cord-005453-4057qib7 6210 1 Compared compare VBN cord-005453-4057qib7 6210 2 to to IN cord-005453-4057qib7 6210 3 the the DT cord-005453-4057qib7 6210 4 infusion infusion NN cord-005453-4057qib7 6210 5 of of IN cord-005453-4057qib7 6210 6 nonmobilized nonmobilized JJ cord-005453-4057qib7 6210 7 lymphocytes lymphocyte NNS cord-005453-4057qib7 6210 8 , , , cord-005453-4057qib7 6210 9 granulocyte granulocyte NN cord-005453-4057qib7 6210 10 colony colony NN cord-005453-4057qib7 6210 11 - - HYPH cord-005453-4057qib7 6210 12 stimulating stimulate VBG cord-005453-4057qib7 6210 13 factor factor NN cord-005453-4057qib7 6210 14 ( ( -LRB- cord-005453-4057qib7 6210 15 G g NN cord-005453-4057qib7 6210 16 - - HYPH cord-005453-4057qib7 6210 17 CSF)-primed csf)-primed NN cord-005453-4057qib7 6210 18 DLI DLI NNP cord-005453-4057qib7 6210 19 might may MD cord-005453-4057qib7 6210 20 induce induce VB cord-005453-4057qib7 6210 21 a a DT cord-005453-4057qib7 6210 22 stronger strong JJR cord-005453-4057qib7 6210 23 anti anti JJ cord-005453-4057qib7 6210 24 - - JJ cord-005453-4057qib7 6210 25 tumor tumor JJ cord-005453-4057qib7 6210 26 effect effect NN cord-005453-4057qib7 6210 27 and and CC cord-005453-4057qib7 6210 28 reduce reduce VB cord-005453-4057qib7 6210 29 the the DT cord-005453-4057qib7 6210 30 risk risk NN cord-005453-4057qib7 6210 31 of of IN cord-005453-4057qib7 6210 32 infusion infusion NN cord-005453-4057qib7 6210 33 - - HYPH cord-005453-4057qib7 6210 34 induced induce VBN cord-005453-4057qib7 6210 35 GVHD GVHD NNP cord-005453-4057qib7 6210 36 . . . cord-005453-4057qib7 6211 1 Due due IN cord-005453-4057qib7 6211 2 to to IN cord-005453-4057qib7 6211 3 the the DT cord-005453-4057qib7 6211 4 limited limited JJ cord-005453-4057qib7 6211 5 experience experience NN cord-005453-4057qib7 6211 6 of of IN cord-005453-4057qib7 6211 7 G G NNP cord-005453-4057qib7 6211 8 - - HYPH cord-005453-4057qib7 6211 9 CSF CSF NNP cord-005453-4057qib7 6211 10 primed prime VBD cord-005453-4057qib7 6211 11 DLI DLI NNP cord-005453-4057qib7 6211 12 in in IN cord-005453-4057qib7 6211 13 patients patient NNS cord-005453-4057qib7 6211 14 relapsed relapse VBN cord-005453-4057qib7 6211 15 after after IN cord-005453-4057qib7 6211 16 haploidentical haploidentical JJ cord-005453-4057qib7 6211 17 HSCT HSCT NNP cord-005453-4057qib7 6211 18 , , , cord-005453-4057qib7 6211 19 we -PRON- PRP cord-005453-4057qib7 6211 20 conducted conduct VBD cord-005453-4057qib7 6211 21 a a DT cord-005453-4057qib7 6211 22 retrospective retrospective JJ cord-005453-4057qib7 6211 23 study study NN cord-005453-4057qib7 6211 24 of of IN cord-005453-4057qib7 6211 25 all all DT cord-005453-4057qib7 6211 26 patients patient NNS cord-005453-4057qib7 6211 27 at at IN cord-005453-4057qib7 6211 28 our -PRON- PRP$ cord-005453-4057qib7 6211 29 hospital hospital NN cord-005453-4057qib7 6211 30 who who WP cord-005453-4057qib7 6211 31 received receive VBD cord-005453-4057qib7 6211 32 DLI DLI NNP cord-005453-4057qib7 6211 33 for for IN cord-005453-4057qib7 6211 34 the the DT cord-005453-4057qib7 6211 35 relapsed relapse VBN cord-005453-4057qib7 6211 36 hematological hematological JJ cord-005453-4057qib7 6211 37 diseases disease NNS cord-005453-4057qib7 6211 38 following follow VBG cord-005453-4057qib7 6211 39 related relate VBN cord-005453-4057qib7 6211 40 HLA HLA NNP cord-005453-4057qib7 6211 41 - - HYPH cord-005453-4057qib7 6211 42 matched match VBN cord-005453-4057qib7 6211 43 or or CC cord-005453-4057qib7 6211 44 HLA HLA NNP cord-005453-4057qib7 6211 45 - - HYPH cord-005453-4057qib7 6211 46 haploidentical haploidentical JJ cord-005453-4057qib7 6211 47 HSCT HSCT NNP cord-005453-4057qib7 6211 48 . . . cord-005453-4057qib7 6212 1 Methods method NNS cord-005453-4057qib7 6212 2 : : : cord-005453-4057qib7 6213 1 The the DT cord-005453-4057qib7 6213 2 Institutional Institutional NNP cord-005453-4057qib7 6213 3 Research Research NNP cord-005453-4057qib7 6213 4 Board Board NNP cord-005453-4057qib7 6213 5 approved approve VBD cord-005453-4057qib7 6213 6 the the DT cord-005453-4057qib7 6213 7 study study NN cord-005453-4057qib7 6213 8 . . . cord-005453-4057qib7 6214 1 We -PRON- PRP cord-005453-4057qib7 6214 2 identified identify VBD cord-005453-4057qib7 6214 3 94 94 CD cord-005453-4057qib7 6214 4 patients patient NNS cord-005453-4057qib7 6214 5 with with IN cord-005453-4057qib7 6214 6 hematological hematological JJ cord-005453-4057qib7 6214 7 malignancies malignancy NNS cord-005453-4057qib7 6214 8 receiving receive VBG cord-005453-4057qib7 6214 9 DLI DLI NNP cord-005453-4057qib7 6214 10 following follow VBG cord-005453-4057qib7 6214 11 related relate VBN cord-005453-4057qib7 6214 12 allo allo NN cord-005453-4057qib7 6214 13 - - HYPH cord-005453-4057qib7 6214 14 HSCT HSCT NNP cord-005453-4057qib7 6214 15 at at IN cord-005453-4057qib7 6214 16 National National NNP cord-005453-4057qib7 6214 17 Taiwan Taiwan NNP cord-005453-4057qib7 6214 18 University University NNP cord-005453-4057qib7 6214 19 Hospital Hospital NNP cord-005453-4057qib7 6214 20 between between IN cord-005453-4057qib7 6214 21 1999 1999 CD cord-005453-4057qib7 6214 22 and and CC cord-005453-4057qib7 6214 23 2018 2018 CD cord-005453-4057qib7 6214 24 Aug. August NNP cord-005453-4057qib7 6215 1 The the DT cord-005453-4057qib7 6215 2 infusate infusate NN cord-005453-4057qib7 6215 3 was be VBD cord-005453-4057qib7 6215 4 obtained obtain VBN cord-005453-4057qib7 6215 5 from from IN cord-005453-4057qib7 6215 6 the the DT cord-005453-4057qib7 6215 7 cryopreserved cryopreserve VBN cord-005453-4057qib7 6215 8 specimen specimen NN cord-005453-4057qib7 6215 9 , , , cord-005453-4057qib7 6215 10 which which WDT cord-005453-4057qib7 6215 11 had have VBD cord-005453-4057qib7 6215 12 been be VBN cord-005453-4057qib7 6215 13 collected collect VBN cord-005453-4057qib7 6215 14 and and CC cord-005453-4057qib7 6215 15 stored store VBN cord-005453-4057qib7 6215 16 at at IN cord-005453-4057qib7 6215 17 multiple multiple JJ cord-005453-4057qib7 6215 18 aliquots aliquot NNS cord-005453-4057qib7 6215 19 at at IN cord-005453-4057qib7 6215 20 the the DT cord-005453-4057qib7 6215 21 same same JJ cord-005453-4057qib7 6215 22 time time NN cord-005453-4057qib7 6215 23 as as IN cord-005453-4057qib7 6215 24 the the DT cord-005453-4057qib7 6215 25 initial initial JJ cord-005453-4057qib7 6215 26 haploidentical haploidentical JJ cord-005453-4057qib7 6215 27 peripheral peripheral JJ cord-005453-4057qib7 6215 28 stem stem NN cord-005453-4057qib7 6215 29 cell cell NN cord-005453-4057qib7 6215 30 graft graft NN cord-005453-4057qib7 6215 31 . . . cord-005453-4057qib7 6216 1 Patients patient NNS cord-005453-4057qib7 6216 2 received receive VBD cord-005453-4057qib7 6216 3 DLI DLI NNP cord-005453-4057qib7 6216 4 for for IN cord-005453-4057qib7 6216 5 either either DT cord-005453-4057qib7 6216 6 hematological hematological JJ cord-005453-4057qib7 6216 7 relapse relapse NN cord-005453-4057qib7 6216 8 , , , cord-005453-4057qib7 6216 9 preemptive preemptive JJ cord-005453-4057qib7 6216 10 or or CC cord-005453-4057qib7 6216 11 prophylactic prophylactic JJ cord-005453-4057qib7 6216 12 treatment treatment NN cord-005453-4057qib7 6216 13 . . . cord-005453-4057qib7 6217 1 Univariate univariate JJ cord-005453-4057qib7 6217 2 and and CC cord-005453-4057qib7 6217 3 multivariate multivariate JJ cord-005453-4057qib7 6217 4 analysis analysis NN cord-005453-4057qib7 6217 5 was be VBD cord-005453-4057qib7 6217 6 performed perform VBN cord-005453-4057qib7 6217 7 using use VBG cord-005453-4057qib7 6217 8 Cox Cox NNP cord-005453-4057qib7 6217 9 proportional proportional JJ cord-005453-4057qib7 6217 10 hazard hazard NN cord-005453-4057qib7 6217 11 regression regression NN cord-005453-4057qib7 6217 12 model model NN cord-005453-4057qib7 6217 13 . . . cord-005453-4057qib7 6218 1 Results result NNS cord-005453-4057qib7 6218 2 : : : cord-005453-4057qib7 6219 1 For for IN cord-005453-4057qib7 6219 2 the the DT cord-005453-4057qib7 6219 3 61 61 CD cord-005453-4057qib7 6219 4 patients patient NNS cord-005453-4057qib7 6219 5 following follow VBG cord-005453-4057qib7 6219 6 related related JJ cord-005453-4057qib7 6219 7 HLAmatched HLAmatched NNP cord-005453-4057qib7 6219 8 and and CC cord-005453-4057qib7 6219 9 the the DT cord-005453-4057qib7 6219 10 33 33 CD cord-005453-4057qib7 6219 11 patients patient NNS cord-005453-4057qib7 6219 12 following follow VBG cord-005453-4057qib7 6219 13 HLA HLA NNP cord-005453-4057qib7 6219 14 - - HYPH cord-005453-4057qib7 6219 15 haploidentical haploidentical JJ cord-005453-4057qib7 6219 16 HSCT HSCT NNP cord-005453-4057qib7 6219 17 received receive VBD cord-005453-4057qib7 6219 18 119 119 CD cord-005453-4057qib7 6219 19 and and CC cord-005453-4057qib7 6219 20 72 72 CD cord-005453-4057qib7 6219 21 doses dose NNS cord-005453-4057qib7 6219 22 of of IN cord-005453-4057qib7 6219 23 DLI DLI NNP cord-005453-4057qib7 6219 24 , , , cord-005453-4057qib7 6219 25 respectively respectively RB cord-005453-4057qib7 6219 26 . . . cord-005453-4057qib7 6220 1 In in IN cord-005453-4057qib7 6220 2 comparison comparison NN cord-005453-4057qib7 6220 3 , , , cord-005453-4057qib7 6220 4 the the DT cord-005453-4057qib7 6220 5 median median JJ cord-005453-4057qib7 6220 6 CD3 CD3 NNP cord-005453-4057qib7 6220 7 + + CC cord-005453-4057qib7 6220 8 cell cell NN cord-005453-4057qib7 6220 9 dosage dosage NN cord-005453-4057qib7 6220 10 of of IN cord-005453-4057qib7 6220 11 haplo haplo NNP cord-005453-4057qib7 6220 12 - - HYPH cord-005453-4057qib7 6220 13 DLI DLI NNP cord-005453-4057qib7 6220 14 is be VBZ cord-005453-4057qib7 6220 15 significantly significantly RB cord-005453-4057qib7 6220 16 lower low JJR cord-005453-4057qib7 6220 17 ( ( -LRB- cord-005453-4057qib7 6220 18 P p NN cord-005453-4057qib7 6220 19 = = SYM cord-005453-4057qib7 6220 20 0.0224 0.0224 CD cord-005453-4057qib7 6220 21 ) ) -RRB- cord-005453-4057qib7 6220 22 than than IN cord-005453-4057qib7 6220 23 that that DT cord-005453-4057qib7 6220 24 of of IN cord-005453-4057qib7 6220 25 DLI DLI NNP cord-005453-4057qib7 6220 26 from from IN cord-005453-4057qib7 6220 27 sibling sibling NN cord-005453-4057qib7 6220 28 donors donor NNS cord-005453-4057qib7 6220 29 , , , cord-005453-4057qib7 6220 30 with with IN cord-005453-4057qib7 6220 31 median median JJ cord-005453-4057qib7 6220 32 cell cell NN cord-005453-4057qib7 6220 33 dosage dosage NN cord-005453-4057qib7 6220 34 0.45 0.45 CD cord-005453-4057qib7 6220 35 × × NNP cord-005453-4057qib7 6220 36 10 10 CD cord-005453-4057qib7 6220 37 7 7 CD cord-005453-4057qib7 6221 1 /kg /kg . cord-005453-4057qib7 6222 1 ( ( -LRB- cord-005453-4057qib7 6222 2 range range NN cord-005453-4057qib7 6222 3 , , , cord-005453-4057qib7 6222 4 0.05 0.05 CD cord-005453-4057qib7 6222 5 - - SYM cord-005453-4057qib7 6222 6 12 12 CD cord-005453-4057qib7 6222 7 × × NN cord-005453-4057qib7 6222 8 10 10 CD cord-005453-4057qib7 6222 9 7 7 CD cord-005453-4057qib7 6222 10 /kg /kg CD cord-005453-4057qib7 6222 11 ) ) -RRB- cord-005453-4057qib7 6222 12 and and CC cord-005453-4057qib7 6222 13 1.1 1.1 CD cord-005453-4057qib7 6222 14 × × NN cord-005453-4057qib7 6222 15 10 10 CD cord-005453-4057qib7 6222 16 7 7 CD cord-005453-4057qib7 6222 17 /kg /kg . cord-005453-4057qib7 6222 18 ( ( -LRB- cord-005453-4057qib7 6222 19 range range NN cord-005453-4057qib7 6222 20 , , , cord-005453-4057qib7 6222 21 0.04 0.04 CD cord-005453-4057qib7 6222 22 - - SYM cord-005453-4057qib7 6222 23 9.78 9.78 CD cord-005453-4057qib7 6222 24 × × NN cord-005453-4057qib7 6222 25 10 10 CD cord-005453-4057qib7 6222 26 7 7 CD cord-005453-4057qib7 6222 27 /kg /kg CD cord-005453-4057qib7 6222 28 ) ) -RRB- cord-005453-4057qib7 6222 29 , , , cord-005453-4057qib7 6222 30 respectively respectively RB cord-005453-4057qib7 6222 31 . . . cord-005453-4057qib7 6223 1 The the DT cord-005453-4057qib7 6223 2 median median JJ cord-005453-4057qib7 6223 3 time time NN cord-005453-4057qib7 6223 4 to to IN cord-005453-4057qib7 6223 5 DLI DLI NNP cord-005453-4057qib7 6223 6 from from IN cord-005453-4057qib7 6223 7 initial initial JJ cord-005453-4057qib7 6223 8 sibling sibling NN cord-005453-4057qib7 6223 9 HSCT HSCT NNP cord-005453-4057qib7 6223 10 and and CC cord-005453-4057qib7 6223 11 haplo haplo NNP cord-005453-4057qib7 6223 12 - - HYPH cord-005453-4057qib7 6223 13 HSCT HSCT NNP cord-005453-4057qib7 6223 14 was be VBD cord-005453-4057qib7 6223 15 152 152 CD cord-005453-4057qib7 6223 16 days day NNS cord-005453-4057qib7 6223 17 ( ( -LRB- cord-005453-4057qib7 6223 18 range range NN cord-005453-4057qib7 6223 19 , , , cord-005453-4057qib7 6223 20 13 13 CD cord-005453-4057qib7 6223 21 - - SYM cord-005453-4057qib7 6223 22 3357 3357 CD cord-005453-4057qib7 6223 23 days day NNS cord-005453-4057qib7 6223 24 ) ) -RRB- cord-005453-4057qib7 6223 25 and and CC cord-005453-4057qib7 6223 26 155 155 CD cord-005453-4057qib7 6223 27 days day NNS cord-005453-4057qib7 6223 28 ( ( -LRB- cord-005453-4057qib7 6223 29 range range NN cord-005453-4057qib7 6223 30 , , , cord-005453-4057qib7 6223 31 13 13 CD cord-005453-4057qib7 6223 32 - - SYM cord-005453-4057qib7 6223 33 946 946 CD cord-005453-4057qib7 6223 34 days day NNS cord-005453-4057qib7 6223 35 ) ) -RRB- cord-005453-4057qib7 6223 36 , , , cord-005453-4057qib7 6223 37 respectively respectively RB cord-005453-4057qib7 6223 38 . . . cord-005453-4057qib7 6224 1 Overall overall RB cord-005453-4057qib7 6224 2 , , , cord-005453-4057qib7 6224 3 12 12 CD cord-005453-4057qib7 6224 4 ( ( -LRB- cord-005453-4057qib7 6224 5 20 20 CD cord-005453-4057qib7 6224 6 % % NN cord-005453-4057qib7 6224 7 ) ) -RRB- cord-005453-4057qib7 6224 8 of of IN cord-005453-4057qib7 6224 9 the the DT cord-005453-4057qib7 6224 10 61 61 CD cord-005453-4057qib7 6224 11 patients patient NNS cord-005453-4057qib7 6224 12 following follow VBG cord-005453-4057qib7 6224 13 sibling sibling NN cord-005453-4057qib7 6224 14 HSCT HSCT NNP cord-005453-4057qib7 6224 15 developed develop VBD cord-005453-4057qib7 6224 16 grade grade NN cord-005453-4057qib7 6224 17 2 2 CD cord-005453-4057qib7 6224 18 - - SYM cord-005453-4057qib7 6224 19 4 4 CD cord-005453-4057qib7 6224 20 acute acute JJ cord-005453-4057qib7 6224 21 GVHD GVHD NNP cord-005453-4057qib7 6224 22 after after IN cord-005453-4057qib7 6224 23 DLI DLI NNP cord-005453-4057qib7 6224 24 , , , cord-005453-4057qib7 6224 25 whereas whereas IN cord-005453-4057qib7 6224 26 12 12 CD cord-005453-4057qib7 6224 27 ( ( -LRB- cord-005453-4057qib7 6224 28 36 36 CD cord-005453-4057qib7 6224 29 % % NN cord-005453-4057qib7 6224 30 ) ) -RRB- cord-005453-4057qib7 6224 31 of of IN cord-005453-4057qib7 6224 32 the the DT cord-005453-4057qib7 6224 33 33 33 CD cord-005453-4057qib7 6224 34 patients patient NNS cord-005453-4057qib7 6224 35 receiving receive VBG cord-005453-4057qib7 6224 36 haplo haplo NNP cord-005453-4057qib7 6224 37 - - HYPH cord-005453-4057qib7 6224 38 HSCT HSCT NNP cord-005453-4057qib7 6224 39 developed develop VBD cord-005453-4057qib7 6224 40 grade grade NN cord-005453-4057qib7 6224 41 2 2 CD cord-005453-4057qib7 6224 42 - - SYM cord-005453-4057qib7 6224 43 4 4 CD cord-005453-4057qib7 6224 44 acute acute JJ cord-005453-4057qib7 6224 45 GVHD GVHD NNP cord-005453-4057qib7 6224 46 after after IN cord-005453-4057qib7 6224 47 DLI DLI NNP cord-005453-4057qib7 6224 48 ( ( -LRB- cord-005453-4057qib7 6224 49 p=0.1460 p=0.1460 NNP cord-005453-4057qib7 6224 50 ) ) -RRB- cord-005453-4057qib7 6224 51 . . . cord-005453-4057qib7 6225 1 Importantly importantly RB cord-005453-4057qib7 6225 2 , , , cord-005453-4057qib7 6225 3 for for IN cord-005453-4057qib7 6225 4 patients patient NNS cord-005453-4057qib7 6225 5 receiving receive VBG cord-005453-4057qib7 6225 6 DLI DLI NNP cord-005453-4057qib7 6225 7 with with IN cord-005453-4057qib7 6225 8 CD3 CD3 NNP cord-005453-4057qib7 6225 9 + + CC cord-005453-4057qib7 6225 10 cell cell NN cord-005453-4057qib7 6225 11 dosage dosage NN cord-005453-4057qib7 6225 12 less less JJR cord-005453-4057qib7 6225 13 than than IN cord-005453-4057qib7 6225 14 1 1 CD cord-005453-4057qib7 6225 15 × × CD cord-005453-4057qib7 6225 16 10 10 CD cord-005453-4057qib7 6225 17 7 7 CD cord-005453-4057qib7 6226 1 /kg /kg NFP cord-005453-4057qib7 6226 2 , , , cord-005453-4057qib7 6226 3 there there EX cord-005453-4057qib7 6226 4 is be VBZ cord-005453-4057qib7 6226 5 no no DT cord-005453-4057qib7 6226 6 difference difference NN cord-005453-4057qib7 6226 7 in in IN cord-005453-4057qib7 6226 8 the the DT cord-005453-4057qib7 6226 9 risk risk NN cord-005453-4057qib7 6226 10 of of IN cord-005453-4057qib7 6226 11 developing develop VBG cord-005453-4057qib7 6226 12 grade grade NN cord-005453-4057qib7 6226 13 2 2 CD cord-005453-4057qib7 6226 14 - - SYM cord-005453-4057qib7 6226 15 4 4 CD cord-005453-4057qib7 6226 16 acute acute JJ cord-005453-4057qib7 6226 17 GVHD GVHD NNP cord-005453-4057qib7 6226 18 between between IN cord-005453-4057qib7 6226 19 patients patient NNS cord-005453-4057qib7 6226 20 receiving receive VBG cord-005453-4057qib7 6226 21 DLI DLI NNP cord-005453-4057qib7 6226 22 from from IN cord-005453-4057qib7 6226 23 sibling sibling NN cord-005453-4057qib7 6226 24 or or CC cord-005453-4057qib7 6226 25 haplo haplo NN cord-005453-4057qib7 6226 26 donors donor NNS cord-005453-4057qib7 6226 27 ( ( -LRB- cord-005453-4057qib7 6226 28 Figure figure NN cord-005453-4057qib7 6226 29 1A 1a NN cord-005453-4057qib7 6226 30 ) ) -RRB- cord-005453-4057qib7 6226 31 . . . cord-005453-4057qib7 6227 1 Interestingly interestingly RB cord-005453-4057qib7 6227 2 , , , cord-005453-4057qib7 6227 3 for for IN cord-005453-4057qib7 6227 4 patients patient NNS cord-005453-4057qib7 6227 5 receiving receive VBG cord-005453-4057qib7 6227 6 DLI DLI NNP cord-005453-4057qib7 6227 7 with with IN cord-005453-4057qib7 6227 8 CD3 CD3 NNP cord-005453-4057qib7 6227 9 + + CC cord-005453-4057qib7 6227 10 cell cell NN cord-005453-4057qib7 6227 11 dosage dosage NN cord-005453-4057qib7 6227 12 more more JJR cord-005453-4057qib7 6227 13 than than IN cord-005453-4057qib7 6227 14 or or CC cord-005453-4057qib7 6227 15 equal equal JJ cord-005453-4057qib7 6227 16 to to IN cord-005453-4057qib7 6227 17 1× 1× CD cord-005453-4057qib7 6227 18 10 10 CD cord-005453-4057qib7 6227 19 7 7 CD cord-005453-4057qib7 6228 1 /kg /kg NFP cord-005453-4057qib7 6228 2 , , , cord-005453-4057qib7 6228 3 4 4 CD cord-005453-4057qib7 6228 4 ( ( -LRB- cord-005453-4057qib7 6228 5 50 50 CD cord-005453-4057qib7 6228 6 % % NN cord-005453-4057qib7 6228 7 ) ) -RRB- cord-005453-4057qib7 6228 8 of of IN cord-005453-4057qib7 6228 9 the the DT cord-005453-4057qib7 6228 10 8 8 CD cord-005453-4057qib7 6228 11 patients patient NNS cord-005453-4057qib7 6228 12 following follow VBG cord-005453-4057qib7 6228 13 haplo haplo NNP cord-005453-4057qib7 6228 14 - - HYPH cord-005453-4057qib7 6228 15 HSCT HSCT NNP cord-005453-4057qib7 6228 16 developed develop VBD cord-005453-4057qib7 6228 17 grade grade NN cord-005453-4057qib7 6228 18 2 2 CD cord-005453-4057qib7 6228 19 - - SYM cord-005453-4057qib7 6228 20 4 4 CD cord-005453-4057qib7 6228 21 acute acute JJ cord-005453-4057qib7 6228 22 GVHD GVHD NNP cord-005453-4057qib7 6228 23 after after IN cord-005453-4057qib7 6228 24 DLI DLI NNP cord-005453-4057qib7 6228 25 , , , cord-005453-4057qib7 6228 26 significantly significantly RB cord-005453-4057qib7 6228 27 more more JJR cord-005453-4057qib7 6228 28 than than IN cord-005453-4057qib7 6228 29 5 5 CD cord-005453-4057qib7 6228 30 ( ( -LRB- cord-005453-4057qib7 6228 31 14 14 CD cord-005453-4057qib7 6228 32 % % NN cord-005453-4057qib7 6228 33 ) ) -RRB- cord-005453-4057qib7 6228 34 of of IN cord-005453-4057qib7 6228 35 the the DT cord-005453-4057qib7 6228 36 37 37 CD cord-005453-4057qib7 6228 37 patients patient NNS cord-005453-4057qib7 6228 38 following follow VBG cord-005453-4057qib7 6228 39 sibling sibling NN cord-005453-4057qib7 6228 40 HSCT HSCT NNP cord-005453-4057qib7 6228 41 developed develop VBD cord-005453-4057qib7 6228 42 grade grade NN cord-005453-4057qib7 6228 43 2 2 CD cord-005453-4057qib7 6228 44 - - SYM cord-005453-4057qib7 6228 45 4 4 CD cord-005453-4057qib7 6228 46 acute acute JJ cord-005453-4057qib7 6228 47 GVHD GVHD NNP cord-005453-4057qib7 6228 48 after after IN cord-005453-4057qib7 6228 49 DLI DLI NNP cord-005453-4057qib7 6228 50 ( ( -LRB- cord-005453-4057qib7 6228 51 Figure figure NN cord-005453-4057qib7 6228 52 1B 1b CD cord-005453-4057qib7 6228 53 ) ) -RRB- cord-005453-4057qib7 6228 54 . . . cord-005453-4057qib7 6229 1 The the DT cord-005453-4057qib7 6229 2 cumulative cumulative JJ cord-005453-4057qib7 6229 3 incidence incidence NN cord-005453-4057qib7 6229 4 of of IN cord-005453-4057qib7 6229 5 grade grade NN cord-005453-4057qib7 6229 6 2 2 CD cord-005453-4057qib7 6229 7 - - SYM cord-005453-4057qib7 6229 8 4 4 CD cord-005453-4057qib7 6229 9 acute acute JJ cord-005453-4057qib7 6229 10 GVHD GVHD NNP cord-005453-4057qib7 6229 11 at at IN cord-005453-4057qib7 6229 12 day day NN cord-005453-4057qib7 6229 13 100 100 CD cord-005453-4057qib7 6229 14 after after IN cord-005453-4057qib7 6229 15 haplo haplo NN cord-005453-4057qib7 6229 16 - - HYPH cord-005453-4057qib7 6229 17 HSCT HSCT NNP cord-005453-4057qib7 6229 18 and and CC cord-005453-4057qib7 6229 19 sibling sibling NN cord-005453-4057qib7 6229 20 HSCT HSCT NNP cord-005453-4057qib7 6229 21 were be VBD cord-005453-4057qib7 6229 22 50 50 CD cord-005453-4057qib7 6229 23 % % NN cord-005453-4057qib7 6229 24 ( ( -LRB- cord-005453-4057qib7 6229 25 95 95 CD cord-005453-4057qib7 6229 26 % % NN cord-005453-4057qib7 6229 27 CI ci NN cord-005453-4057qib7 6229 28 : : : cord-005453-4057qib7 6229 29 0.13 0.13 CD cord-005453-4057qib7 6229 30 -0.79 -0.79 NFP cord-005453-4057qib7 6229 31 ) ) -RRB- cord-005453-4057qib7 6229 32 and and CC cord-005453-4057qib7 6229 33 13.5 13.5 CD cord-005453-4057qib7 6229 34 % % NN cord-005453-4057qib7 6229 35 ( ( -LRB- cord-005453-4057qib7 6229 36 95 95 CD cord-005453-4057qib7 6229 37 % % NN cord-005453-4057qib7 6229 38 CI ci NN cord-005453-4057qib7 6229 39 : : : cord-005453-4057qib7 6229 40 0.05 0.05 CD cord-005453-4057qib7 6229 41 - - HYPH cord-005453-4057qib7 6229 42 0.27 0.27 CD cord-005453-4057qib7 6229 43 ) ) -RRB- cord-005453-4057qib7 6229 44 , , , cord-005453-4057qib7 6229 45 respectively respectively RB cord-005453-4057qib7 6229 46 ( ( -LRB- cord-005453-4057qib7 6229 47 Figure figure NN cord-005453-4057qib7 6229 48 1B 1b NN cord-005453-4057qib7 6229 49 , , , cord-005453-4057qib7 6229 50 P p NN cord-005453-4057qib7 6229 51 = = SYM cord-005453-4057qib7 6229 52 0.0146 0.0146 CD cord-005453-4057qib7 6229 53 ) ) -RRB- cord-005453-4057qib7 6229 54 . . . cord-005453-4057qib7 6230 1 [ [ -LRB- cord-005453-4057qib7 6230 2 [ [ -LRB- cord-005453-4057qib7 6230 3 P282 P282 NNP cord-005453-4057qib7 6230 4 Image image NN cord-005453-4057qib7 6230 5 ] ] -RRB- cord-005453-4057qib7 6230 6 1 1 CD cord-005453-4057qib7 6230 7 . . . cord-005453-4057qib7 6231 1 Conclusions conclusion NNS cord-005453-4057qib7 6231 2 : : : cord-005453-4057qib7 6232 1 Our -PRON- PRP$ cord-005453-4057qib7 6232 2 study study NN cord-005453-4057qib7 6232 3 shows show VBZ cord-005453-4057qib7 6232 4 that that IN cord-005453-4057qib7 6232 5 the the DT cord-005453-4057qib7 6232 6 administration administration NN cord-005453-4057qib7 6232 7 of of IN cord-005453-4057qib7 6232 8 G G NNP cord-005453-4057qib7 6232 9 - - HYPH cord-005453-4057qib7 6232 10 CSF CSF NNP cord-005453-4057qib7 6232 11 mobilized mobilize VBD cord-005453-4057qib7 6232 12 DLI DLI NNP cord-005453-4057qib7 6232 13 is be VBZ cord-005453-4057qib7 6232 14 feasible feasible JJ cord-005453-4057qib7 6232 15 after after IN cord-005453-4057qib7 6232 16 haploidentical haploidentical JJ cord-005453-4057qib7 6232 17 HSCT HSCT NNP cord-005453-4057qib7 6232 18 for for IN cord-005453-4057qib7 6232 19 relapsed relapse VBN cord-005453-4057qib7 6232 20 hematological hematological JJ cord-005453-4057qib7 6232 21 malignancies malignancy NNS cord-005453-4057qib7 6232 22 . . . cord-005453-4057qib7 6233 1 However however RB cord-005453-4057qib7 6233 2 , , , cord-005453-4057qib7 6233 3 DLI DLI NNP cord-005453-4057qib7 6233 4 with with IN cord-005453-4057qib7 6233 5 CD3 CD3 NNP cord-005453-4057qib7 6233 6 + + CC cord-005453-4057qib7 6233 7 cell cell NN cord-005453-4057qib7 6233 8 dosage dosage NN cord-005453-4057qib7 6233 9 more more JJR cord-005453-4057qib7 6233 10 than than IN cord-005453-4057qib7 6233 11 or or CC cord-005453-4057qib7 6233 12 equal equal JJ cord-005453-4057qib7 6233 13 to to IN cord-005453-4057qib7 6233 14 1× 1× CD cord-005453-4057qib7 6233 15 10 10 CD cord-005453-4057qib7 6233 16 7 7 CD cord-005453-4057qib7 6234 1 /kg /kg NFP cord-005453-4057qib7 6234 2 in in IN cord-005453-4057qib7 6234 3 patients patient NNS cord-005453-4057qib7 6234 4 receiving receive VBG cord-005453-4057qib7 6234 5 haplo haplo NNP cord-005453-4057qib7 6234 6 - - HYPH cord-005453-4057qib7 6234 7 HSCT HSCT NNP cord-005453-4057qib7 6235 1 is be VBZ cord-005453-4057qib7 6235 2 associated associate VBN cord-005453-4057qib7 6235 3 with with IN cord-005453-4057qib7 6235 4 significantly significantly RB cord-005453-4057qib7 6235 5 higher high JJR cord-005453-4057qib7 6235 6 risk risk NN cord-005453-4057qib7 6235 7 of of IN cord-005453-4057qib7 6235 8 developing develop VBG cord-005453-4057qib7 6235 9 acute acute JJ cord-005453-4057qib7 6235 10 GVHD GVHD NNP cord-005453-4057qib7 6235 11 than than IN cord-005453-4057qib7 6235 12 DLI DLI NNP cord-005453-4057qib7 6235 13 from from IN cord-005453-4057qib7 6235 14 the the DT cord-005453-4057qib7 6235 15 sibling sibling NN cord-005453-4057qib7 6235 16 donors donor NNS cord-005453-4057qib7 6235 17 . . . cord-005453-4057qib7 6236 1 Disclosure disclosure NN cord-005453-4057qib7 6236 2 : : : cord-005453-4057qib7 6237 1 The the DT cord-005453-4057qib7 6237 2 authors author NNS cord-005453-4057qib7 6237 3 declare declare VBP cord-005453-4057qib7 6237 4 no no DT cord-005453-4057qib7 6237 5 competing compete VBG cord-005453-4057qib7 6237 6 financial financial JJ cord-005453-4057qib7 6237 7 interests interest NNS cord-005453-4057qib7 6237 8 . . . cord-005453-4057qib7 6238 1 Background background NN cord-005453-4057qib7 6238 2 : : : cord-005453-4057qib7 6239 1 The the DT cord-005453-4057qib7 6239 2 Fresenius Fresenius NNP cord-005453-4057qib7 6239 3 Phelix Phelix NNP cord-005453-4057qib7 6239 4 is be VBZ cord-005453-4057qib7 6239 5 a a DT cord-005453-4057qib7 6239 6 UVA UVA NNP cord-005453-4057qib7 6239 7 irradiation irradiation NN cord-005453-4057qib7 6239 8 device device NN cord-005453-4057qib7 6239 9 used use VBN cord-005453-4057qib7 6239 10 to to TO cord-005453-4057qib7 6239 11 photoactivate photoactivate VB cord-005453-4057qib7 6239 12 MNC MNC NNP cord-005453-4057qib7 6239 13 collected collect VBN cord-005453-4057qib7 6239 14 on on IN cord-005453-4057qib7 6239 15 the the DT cord-005453-4057qib7 6239 16 Amicus Amicus NNP cord-005453-4057qib7 6239 17 . . . cord-005453-4057qib7 6240 1 The the DT cord-005453-4057qib7 6240 2 system system NN cord-005453-4057qib7 6240 3 is be VBZ cord-005453-4057qib7 6240 4 closed close VBN cord-005453-4057qib7 6240 5 , , , cord-005453-4057qib7 6240 6 utilizing utilize VBG cord-005453-4057qib7 6240 7 a a DT cord-005453-4057qib7 6240 8 special special JJ cord-005453-4057qib7 6240 9 MNC MNC NNP cord-005453-4057qib7 6240 10 kit kit NN cord-005453-4057qib7 6240 11 and and CC cord-005453-4057qib7 6240 12 modified modify VBN cord-005453-4057qib7 6240 13 instrument instrument NN cord-005453-4057qib7 6240 14 software software NN cord-005453-4057qib7 6240 15 . . . cord-005453-4057qib7 6241 1 The the DT cord-005453-4057qib7 6241 2 preliminary preliminary JJ cord-005453-4057qib7 6241 3 results result NNS cord-005453-4057qib7 6241 4 of of IN cord-005453-4057qib7 6241 5 a a DT cord-005453-4057qib7 6241 6 phase phase NN cord-005453-4057qib7 6241 7 I -PRON- PRP cord-005453-4057qib7 6241 8 safety safety NN cord-005453-4057qib7 6241 9 trial trial NN cord-005453-4057qib7 6241 10 involving involve VBG cord-005453-4057qib7 6241 11 three three CD cord-005453-4057qib7 6241 12 patients patient NNS cord-005453-4057qib7 6241 13 ( ( -LRB- cord-005453-4057qib7 6241 14 12 12 CD cord-005453-4057qib7 6241 15 treatments treatment NNS cord-005453-4057qib7 6241 16 ) ) -RRB- cord-005453-4057qib7 6241 17 with with IN cord-005453-4057qib7 6241 18 chronic chronic JJ cord-005453-4057qib7 6241 19 graft graft NN cord-005453-4057qib7 6241 20 vs. vs. IN cord-005453-4057qib7 6241 21 host host NN cord-005453-4057qib7 6241 22 disease disease NN cord-005453-4057qib7 6241 23 are be VBP cord-005453-4057qib7 6241 24 presented present VBN cord-005453-4057qib7 6241 25 . . . cord-005453-4057qib7 6242 1 Methods method NNS cord-005453-4057qib7 6242 2 : : : cord-005453-4057qib7 6242 3 Reasons reason NNS cord-005453-4057qib7 6242 4 for for IN cord-005453-4057qib7 6242 5 transplantation transplantation NN cord-005453-4057qib7 6242 6 for for IN cord-005453-4057qib7 6242 7 the the DT cord-005453-4057qib7 6242 8 patients patient NNS cord-005453-4057qib7 6242 9 ages age NNS cord-005453-4057qib7 6242 10 37 37 CD cord-005453-4057qib7 6242 11 , , , cord-005453-4057qib7 6242 12 61 61 CD cord-005453-4057qib7 6242 13 and and CC cord-005453-4057qib7 6242 14 62 62 CD cord-005453-4057qib7 6242 15 years year NNS cord-005453-4057qib7 6243 1 were be VBD cord-005453-4057qib7 6243 2 : : : cord-005453-4057qib7 6243 3 Acute acute JJ cord-005453-4057qib7 6243 4 myelogenous myelogenous NN cord-005453-4057qib7 6243 5 leukemia leukemia NN cord-005453-4057qib7 6243 6 , , , cord-005453-4057qib7 6243 7 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 6243 8 syndrome syndrome NN cord-005453-4057qib7 6243 9 , , , cord-005453-4057qib7 6243 10 and and CC cord-005453-4057qib7 6243 11 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 6243 12 syndrome syndrome NN cord-005453-4057qib7 6243 13 with with IN cord-005453-4057qib7 6243 14 PNH PNH NNP cord-005453-4057qib7 6243 15 . . . cord-005453-4057qib7 6244 1 Stem stem JJ cord-005453-4057qib7 6244 2 cell cell NN cord-005453-4057qib7 6244 3 source source NN cord-005453-4057qib7 6244 4 was be VBD cord-005453-4057qib7 6244 5 peripheral peripheral JJ cord-005453-4057qib7 6244 6 blood blood NN cord-005453-4057qib7 6244 7 with with IN cord-005453-4057qib7 6244 8 a a DT cord-005453-4057qib7 6244 9 10/10 10/10 CD cord-005453-4057qib7 6244 10 match match NN cord-005453-4057qib7 6244 11 for for IN cord-005453-4057qib7 6244 12 all all DT cord-005453-4057qib7 6244 13 . . . cord-005453-4057qib7 6245 1 Each each DT cord-005453-4057qib7 6245 2 developed develop VBD cord-005453-4057qib7 6245 3 chronic chronic NN cord-005453-4057qib7 6245 4 skin skin NN cord-005453-4057qib7 6245 5 GVHD GVHD NNP cord-005453-4057qib7 6245 6 . . . cord-005453-4057qib7 6246 1 Inclusion inclusion NN cord-005453-4057qib7 6246 2 criteria criterion NNS cord-005453-4057qib7 6246 3 included include VBD cord-005453-4057qib7 6246 4 WBC WBC NNP cord-005453-4057qib7 6246 5 and and CC cord-005453-4057qib7 6246 6 PLT PLT NNP cord-005453-4057qib7 6246 7 counts count VBZ cord-005453-4057qib7 6246 8 > > XX cord-005453-4057qib7 6247 1 1000 1000 CD cord-005453-4057qib7 6247 2 and and CC cord-005453-4057qib7 6247 3 25x10 25x10 CD cord-005453-4057qib7 6247 4 9 9 CD cord-005453-4057qib7 6247 5 /L /l NN cord-005453-4057qib7 6247 6 , , , cord-005453-4057qib7 6247 7 GFR GFR NNP cord-005453-4057qib7 6247 8 > > XX cord-005453-4057qib7 6247 9 30 30 CD cord-005453-4057qib7 6247 10 ml ml NN cord-005453-4057qib7 6247 11 / / SYM cord-005453-4057qib7 6247 12 min min NNP cord-005453-4057qib7 6247 13 / / SYM cord-005453-4057qib7 6247 14 BSA BSA NNP cord-005453-4057qib7 6247 15 , , , cord-005453-4057qib7 6247 16 and and CC cord-005453-4057qib7 6247 17 AST AST NNP cord-005453-4057qib7 6247 18 10 10 CD cord-005453-4057qib7 6247 19 - - SYM cord-005453-4057qib7 6247 20 120 120 CD cord-005453-4057qib7 6247 21 unit unit NN cord-005453-4057qib7 6247 22 / / SYM cord-005453-4057qib7 6247 23 L. L. NNP cord-005453-4057qib7 6247 24 Exclusion Exclusion NNP cord-005453-4057qib7 6247 25 criteria criterion NNS cord-005453-4057qib7 6247 26 included include VBD cord-005453-4057qib7 6247 27 active active JJ cord-005453-4057qib7 6247 28 GI GI NNP cord-005453-4057qib7 6247 29 bleeding bleeding NN cord-005453-4057qib7 6247 30 , , , cord-005453-4057qib7 6247 31 NYHA NYHA NNP cord-005453-4057qib7 6247 32 cardiac cardiac JJ cord-005453-4057qib7 6247 33 disease disease NN cord-005453-4057qib7 6247 34 greater great JJR cord-005453-4057qib7 6247 35 than than IN cord-005453-4057qib7 6247 36 grade grade NN cord-005453-4057qib7 6247 37 III III NNP cord-005453-4057qib7 6247 38 , , , cord-005453-4057qib7 6247 39 and and CC cord-005453-4057qib7 6247 40 the the DT cord-005453-4057qib7 6247 41 presence presence NN cord-005453-4057qib7 6247 42 of of IN cord-005453-4057qib7 6247 43 light light JJ cord-005453-4057qib7 6247 44 - - HYPH cord-005453-4057qib7 6247 45 sensitive sensitive JJ cord-005453-4057qib7 6247 46 diseases disease NNS cord-005453-4057qib7 6247 47 . . . cord-005453-4057qib7 6248 1 Amicus Amicus NNP cord-005453-4057qib7 6248 2 software software NN cord-005453-4057qib7 6248 3 4.51 4.51 CD cord-005453-4057qib7 6248 4 and and CC cord-005453-4057qib7 6248 5 Phelix Phelix NNP cord-005453-4057qib7 6248 6 software software NN cord-005453-4057qib7 6248 7 1.0 1.0 CD cord-005453-4057qib7 6248 8 were be VBD cord-005453-4057qib7 6248 9 used use VBN cord-005453-4057qib7 6248 10 . . . cord-005453-4057qib7 6249 1 Settings setting NNS cord-005453-4057qib7 6249 2 included include VBD cord-005453-4057qib7 6249 3 : : : cord-005453-4057qib7 6249 4 80 80 CD cord-005453-4057qib7 6250 1 ml ml NNP cord-005453-4057qib7 6250 2 / / SYM cord-005453-4057qib7 6250 3 min min NNP cord-005453-4057qib7 6250 4 max max NNP cord-005453-4057qib7 6250 5 draw draw NN cord-005453-4057qib7 6250 6 rate rate NN cord-005453-4057qib7 6250 7 , , , cord-005453-4057qib7 6250 8 2000 2000 CD cord-005453-4057qib7 6250 9 ml ml XX cord-005453-4057qib7 6250 10 fixed fix VBN cord-005453-4057qib7 6250 11 cycle cycle NN cord-005453-4057qib7 6250 12 volume volume NN cord-005453-4057qib7 6250 13 , , , cord-005453-4057qib7 6250 14 1.25 1.25 CD cord-005453-4057qib7 6250 15 mg mg NNP cord-005453-4057qib7 6250 16 / / SYM cord-005453-4057qib7 6250 17 kg kg NNP cord-005453-4057qib7 6250 18 / / SYM cord-005453-4057qib7 6250 19 min min NNP cord-005453-4057qib7 6250 20 citrate citrate NNP cord-005453-4057qib7 6250 21 infusion infusion NN cord-005453-4057qib7 6250 22 rate rate NN cord-005453-4057qib7 6250 23 , , , cord-005453-4057qib7 6250 24 and and CC cord-005453-4057qib7 6250 25 12:1 12:1 CD cord-005453-4057qib7 6250 26 ACD ACD NNP cord-005453-4057qib7 6250 27 - - HYPH cord-005453-4057qib7 6250 28 A a NN cord-005453-4057qib7 6250 29 ratio ratio NN cord-005453-4057qib7 6250 30 . . . cord-005453-4057qib7 6251 1 Venous venous JJ cord-005453-4057qib7 6251 2 access access NN cord-005453-4057qib7 6251 3 was be VBD cord-005453-4057qib7 6251 4 peripheral peripheral JJ cord-005453-4057qib7 6251 5 or or CC cord-005453-4057qib7 6251 6 subcutaneous subcutaneous JJ cord-005453-4057qib7 6251 7 port port NN cord-005453-4057qib7 6251 8 . . . cord-005453-4057qib7 6252 1 Target Target NNP cord-005453-4057qib7 6252 2 UVA UVA NNP cord-005453-4057qib7 6252 3 dose dose NN cord-005453-4057qib7 6252 4 was be VBD cord-005453-4057qib7 6252 5 1.5 1.5 CD cord-005453-4057qib7 6252 6 J J NNP cord-005453-4057qib7 6252 7 / / SYM cord-005453-4057qib7 6252 8 CM CM NNP cord-005453-4057qib7 6252 9 2 2 CD cord-005453-4057qib7 6252 10 and and CC cord-005453-4057qib7 6252 11 8-methoxypsoralen 8-methoxypsoralen CD cord-005453-4057qib7 6252 12 dose dose NN cord-005453-4057qib7 6252 13 was be VBD cord-005453-4057qib7 6252 14 3.4 3.4 CD cord-005453-4057qib7 6252 15 ml ml NN cord-005453-4057qib7 6252 16 . . . cord-005453-4057qib7 6253 1 Results result NNS cord-005453-4057qib7 6253 2 : : : cord-005453-4057qib7 6254 1 The the DT cord-005453-4057qib7 6254 2 following following JJ cord-005453-4057qib7 6254 3 mean mean NN cord-005453-4057qib7 6254 4 + + CC cord-005453-4057qib7 6255 1 SD sd NN cord-005453-4057qib7 6255 2 procedure procedure NN cord-005453-4057qib7 6255 3 results result NNS cord-005453-4057qib7 6255 4 were be VBD cord-005453-4057qib7 6255 5 obtained obtain VBN cord-005453-4057qib7 6255 6 : : : cord-005453-4057qib7 6255 7 2,341 2,341 CD cord-005453-4057qib7 6255 8 + + SYM cord-005453-4057qib7 6255 9 14 14 CD cord-005453-4057qib7 6255 10 ml ml NN cord-005453-4057qib7 6255 11 whole whole JJ cord-005453-4057qib7 6255 12 blood blood NN cord-005453-4057qib7 6255 13 with with IN cord-005453-4057qib7 6255 14 ACD ACD NNP cord-005453-4057qib7 6255 15 - - HYPH cord-005453-4057qib7 6255 16 A a NN cord-005453-4057qib7 6255 17 drawn draw VBN cord-005453-4057qib7 6255 18 , , , cord-005453-4057qib7 6255 19 191 191 CD cord-005453-4057qib7 6255 20 + + CC cord-005453-4057qib7 6256 1 3 3 CD cord-005453-4057qib7 6256 2 ml ml NN cord-005453-4057qib7 6256 3 ACD ACD NNP cord-005453-4057qib7 6256 4 - - HYPH cord-005453-4057qib7 6256 5 A A NNP cord-005453-4057qib7 6256 6 used use VBN cord-005453-4057qib7 6256 7 , , , cord-005453-4057qib7 6257 1 691 691 CD cord-005453-4057qib7 6257 2 + + SYM cord-005453-4057qib7 6257 3 127 127 CD cord-005453-4057qib7 6257 4 ml ml NN cord-005453-4057qib7 6257 5 saline saline NN cord-005453-4057qib7 6257 6 used use VBN cord-005453-4057qib7 6257 7 , , , cord-005453-4057qib7 6257 8 91 91 CD cord-005453-4057qib7 6257 9 + + SYM cord-005453-4057qib7 6257 10 5 5 CD cord-005453-4057qib7 6257 11 minutes minute NNS cord-005453-4057qib7 6257 12 procedure procedure NN cord-005453-4057qib7 6257 13 time time NN cord-005453-4057qib7 6257 14 , , , cord-005453-4057qib7 6257 15 and and CC cord-005453-4057qib7 6257 16 4,881 4,881 CD cord-005453-4057qib7 6257 17 + + SYM cord-005453-4057qib7 6257 18 419 419 CD cord-005453-4057qib7 6257 19 ml ml NNS cord-005453-4057qib7 6257 20 total total JJ cord-005453-4057qib7 6257 21 blood blood NN cord-005453-4057qib7 6257 22 volume volume NN cord-005453-4057qib7 6257 23 . . . cord-005453-4057qib7 6258 1 Minor minor JJ cord-005453-4057qib7 6258 2 alarms alarm NNS cord-005453-4057qib7 6258 3 ( ( -LRB- cord-005453-4057qib7 6258 4 N=4 N=4 NNP cord-005453-4057qib7 6258 5 ) ) -RRB- cord-005453-4057qib7 6258 6 on on IN cord-005453-4057qib7 6258 7 the the DT cord-005453-4057qib7 6258 8 Amicus Amicus NNP cord-005453-4057qib7 6258 9 and and CC cord-005453-4057qib7 6258 10 no no DT cord-005453-4057qib7 6258 11 alarms alarm NNS cord-005453-4057qib7 6258 12 on on IN cord-005453-4057qib7 6258 13 the the DT cord-005453-4057qib7 6258 14 Phelix Phelix NNP cord-005453-4057qib7 6258 15 were be VBD cord-005453-4057qib7 6258 16 encountered encounter VBN cord-005453-4057qib7 6258 17 . . . cord-005453-4057qib7 6259 1 All all DT cord-005453-4057qib7 6259 2 14-day 14-day CD cord-005453-4057qib7 6259 3 aerobic aerobic JJ cord-005453-4057qib7 6259 4 and and CC cord-005453-4057qib7 6259 5 anaerobic anaerobic JJ cord-005453-4057qib7 6259 6 cultures culture NNS cord-005453-4057qib7 6259 7 were be VBD cord-005453-4057qib7 6259 8 negative negative JJ cord-005453-4057qib7 6259 9 and and CC cord-005453-4057qib7 6259 10 mean mean JJ cord-005453-4057qib7 6259 11 endotoxin endotoxin NN cord-005453-4057qib7 6259 12 levels level NNS cord-005453-4057qib7 6259 13 were be VBD cord-005453-4057qib7 6259 14 0.425 0.425 CD cord-005453-4057qib7 6259 15 + + CD cord-005453-4057qib7 6260 1 0.1752 0.1752 CD cord-005453-4057qib7 6260 2 EU EU NNP cord-005453-4057qib7 6260 3 / / SYM cord-005453-4057qib7 6260 4 ml ml NN cord-005453-4057qib7 6260 5 . . . cord-005453-4057qib7 6261 1 Mean mean JJ cord-005453-4057qib7 6262 1 pre pre NNP cord-005453-4057qib7 6262 2 / / SYM cord-005453-4057qib7 6262 3 post post VB cord-005453-4057qib7 6262 4 CBC CBC NNP cord-005453-4057qib7 6262 5 and and CC cord-005453-4057qib7 6262 6 plasma plasma NN cord-005453-4057qib7 6262 7 hemoglobin hemoglobin NN cord-005453-4057qib7 6262 8 levels level NNS cord-005453-4057qib7 6262 9 were be VBD cord-005453-4057qib7 6262 10 : : : cord-005453-4057qib7 6263 1 12.5/11.8 12.5/11.8 CD cord-005453-4057qib7 6263 2 WBC WBC NNP cord-005453-4057qib7 6263 3 , , , cord-005453-4057qib7 6263 4 9.9/9.5 9.9/9.5 CD cord-005453-4057qib7 6263 5 neutrophils neutrophil NNS cord-005453-4057qib7 6263 6 , , , cord-005453-4057qib7 6263 7 0.06/0.05 0.06/0.05 CD cord-005453-4057qib7 6263 8 basophils basophil NNS cord-005453-4057qib7 6263 9 , , , cord-005453-4057qib7 6263 10 0.21/0.15 0.21/0.15 CD cord-005453-4057qib7 6263 11 eosinophils eosinophil NNS cord-005453-4057qib7 6263 12 , , , cord-005453-4057qib7 6263 13 1.06/1.03 1.06/1.03 CD cord-005453-4057qib7 6263 14 lymphocytes lymphocyte NNS cord-005453-4057qib7 6263 15 , , , cord-005453-4057qib7 6263 16 1.23/1.06 1.23/1.06 NNP cord-005453-4057qib7 6263 17 monocytes monocyte NNS cord-005453-4057qib7 6263 18 , , , cord-005453-4057qib7 6263 19 314/293 314/293 CD cord-005453-4057qib7 6263 20 platelets platelet NNS cord-005453-4057qib7 6263 21 x x SYM cord-005453-4057qib7 6263 22 10 10 CD cord-005453-4057qib7 6263 23 9 9 CD cord-005453-4057qib7 6263 24 /L /l CD cord-005453-4057qib7 6263 25 , , , cord-005453-4057qib7 6263 26 40/ 40/ CD cord-005453-4057qib7 6263 27 37 37 CD cord-005453-4057qib7 6263 28 % % NN cord-005453-4057qib7 6263 29 HCT hct NN cord-005453-4057qib7 6263 30 , , , cord-005453-4057qib7 6263 31 13.3/12.2 13.3/12.2 NNP cord-005453-4057qib7 6263 32 g g NN cord-005453-4057qib7 6263 33 / / SYM cord-005453-4057qib7 6263 34 dl dl NNP cord-005453-4057qib7 6263 35 Hgb Hgb NNP cord-005453-4057qib7 6263 36 , , , cord-005453-4057qib7 6263 37 and and CC cord-005453-4057qib7 6263 38 26.8/23.4 26.8/23.4 CD cord-005453-4057qib7 6263 39 mg mg NNP cord-005453-4057qib7 6263 40 / / SYM cord-005453-4057qib7 6263 41 dl dl NN cord-005453-4057qib7 6263 42 plasma plasma NN cord-005453-4057qib7 6263 43 hemoglobin hemoglobin NN cord-005453-4057qib7 6263 44 . . . cord-005453-4057qib7 6264 1 Plasma plasma NN cord-005453-4057qib7 6264 2 hemoglobin hemoglobin NN cord-005453-4057qib7 6264 3 delta delta NN cord-005453-4057qib7 6264 4 in in IN cord-005453-4057qib7 6264 5 the the DT cord-005453-4057qib7 6264 6 product product NN cord-005453-4057qib7 6264 7 was be VBD cord-005453-4057qib7 6265 1 0.00 0.00 CD cord-005453-4057qib7 6265 2 + + SYM cord-005453-4057qib7 6265 3 0.001 0.001 CD cord-005453-4057qib7 6265 4 grams gram NNS cord-005453-4057qib7 6265 5 and and CC cord-005453-4057qib7 6265 6 the the DT cord-005453-4057qib7 6265 7 subject subject NN cord-005453-4057qib7 6265 8 was be VBD cord-005453-4057qib7 6265 9 -0.15 -0.15 CD cord-005453-4057qib7 6265 10 + + SYM cord-005453-4057qib7 6265 11 0.70 0.70 CD cord-005453-4057qib7 6265 12 grams gram NNS cord-005453-4057qib7 6265 13 . . . cord-005453-4057qib7 6266 1 Collected collect VBN cord-005453-4057qib7 6266 2 product product NN cord-005453-4057qib7 6267 1 Hct Hct NNP cord-005453-4057qib7 6267 2 . . . cord-005453-4057qib7 6268 1 Mean mean JJ cord-005453-4057qib7 6268 2 1.95 1.95 CD cord-005453-4057qib7 6268 3 + + SYM cord-005453-4057qib7 6268 4 0.255 0.255 CD cord-005453-4057qib7 6268 5 % % NN cord-005453-4057qib7 6268 6 . . . cord-005453-4057qib7 6269 1 Yields yield NNS cord-005453-4057qib7 6269 2 are be VBP cord-005453-4057qib7 6269 3 in in IN cord-005453-4057qib7 6269 4 the the DT cord-005453-4057qib7 6269 5 table table NN cord-005453-4057qib7 6269 6 . . . cord-005453-4057qib7 6270 1 Adverse adverse JJ cord-005453-4057qib7 6270 2 events event NNS cord-005453-4057qib7 6270 3 included include VBD cord-005453-4057qib7 6270 4 one one CD cord-005453-4057qib7 6270 5 each each DT cord-005453-4057qib7 6270 6 : : : cord-005453-4057qib7 6270 7 Acute acute JJ cord-005453-4057qib7 6270 8 respiratory respiratory JJ cord-005453-4057qib7 6270 9 failure failure NN cord-005453-4057qib7 6270 10 , , , cord-005453-4057qib7 6270 11 respiratory respiratory JJ cord-005453-4057qib7 6270 12 failure failure NN cord-005453-4057qib7 6270 13 , , , cord-005453-4057qib7 6270 14 muscular muscular JJ cord-005453-4057qib7 6270 15 weakness weakness NN cord-005453-4057qib7 6270 16 , , , cord-005453-4057qib7 6270 17 musculoskeletal musculoskeletal JJ cord-005453-4057qib7 6270 18 discomfort discomfort NN cord-005453-4057qib7 6270 19 , , , cord-005453-4057qib7 6270 20 and and CC cord-005453-4057qib7 6270 21 peripheral peripheral JJ cord-005453-4057qib7 6270 22 swelling swelling NN cord-005453-4057qib7 6270 23 . . . cord-005453-4057qib7 6271 1 Three three CD cord-005453-4057qib7 6271 2 of of IN cord-005453-4057qib7 6271 3 four four CD cord-005453-4057qib7 6271 4 events event NNS cord-005453-4057qib7 6271 5 occurred occur VBD cord-005453-4057qib7 6271 6 in in IN cord-005453-4057qib7 6271 7 one one CD cord-005453-4057qib7 6271 8 patient patient NN cord-005453-4057qib7 6271 9 two two CD cord-005453-4057qib7 6271 10 weeks week NNS cord-005453-4057qib7 6271 11 after after IN cord-005453-4057qib7 6271 12 the the DT cord-005453-4057qib7 6271 13 study study NN cord-005453-4057qib7 6271 14 procedure procedure NN cord-005453-4057qib7 6271 15 . . . cord-005453-4057qib7 6272 1 None none NN cord-005453-4057qib7 6272 2 of of IN cord-005453-4057qib7 6272 3 the the DT cord-005453-4057qib7 6272 4 adverse adverse JJ cord-005453-4057qib7 6272 5 events event NNS cord-005453-4057qib7 6272 6 were be VBD cord-005453-4057qib7 6272 7 considered consider VBN cord-005453-4057qib7 6272 8 related related JJ cord-005453-4057qib7 6272 9 to to IN cord-005453-4057qib7 6272 10 the the DT cord-005453-4057qib7 6272 11 procedure procedure NN cord-005453-4057qib7 6272 12 or or CC cord-005453-4057qib7 6272 13 investigational investigational JJ cord-005453-4057qib7 6272 14 product product NN cord-005453-4057qib7 6272 15 . . . cord-005453-4057qib7 6273 1 The the DT cord-005453-4057qib7 6273 2 patient patient NN cord-005453-4057qib7 6273 3 who who WP cord-005453-4057qib7 6273 4 experienced experience VBD cord-005453-4057qib7 6273 5 acute acute JJ cord-005453-4057qib7 6273 6 respiratory respiratory JJ cord-005453-4057qib7 6273 7 failure failure NN cord-005453-4057qib7 6273 8 was be VBD cord-005453-4057qib7 6273 9 removed remove VBN cord-005453-4057qib7 6273 10 from from IN cord-005453-4057qib7 6273 11 the the DT cord-005453-4057qib7 6273 12 study study NN cord-005453-4057qib7 6273 13 because because IN cord-005453-4057qib7 6273 14 of of IN cord-005453-4057qib7 6273 15 death death NN cord-005453-4057qib7 6273 16 due due IN cord-005453-4057qib7 6273 17 to to IN cord-005453-4057qib7 6273 18 pneumonia pneumonia NN cord-005453-4057qib7 6273 19 , , , cord-005453-4057qib7 6273 20 felt feel VBD cord-005453-4057qib7 6273 21 to to TO cord-005453-4057qib7 6273 22 be be VB cord-005453-4057qib7 6273 23 unrelated unrelated JJ cord-005453-4057qib7 6273 24 to to IN cord-005453-4057qib7 6273 25 the the DT cord-005453-4057qib7 6273 26 procedure procedure NN cord-005453-4057qib7 6273 27 . . . cord-005453-4057qib7 6274 1 Conclusions conclusion NNS cord-005453-4057qib7 6274 2 : : : cord-005453-4057qib7 6275 1 Results result NNS cord-005453-4057qib7 6275 2 indicate indicate VBP cord-005453-4057qib7 6275 3 the the DT cord-005453-4057qib7 6275 4 new new JJ cord-005453-4057qib7 6275 5 closed closed JJ cord-005453-4057qib7 6275 6 photopheresis photopheresis NN cord-005453-4057qib7 6275 7 system system NN cord-005453-4057qib7 6275 8 is be VBZ cord-005453-4057qib7 6275 9 capable capable JJ cord-005453-4057qib7 6275 10 of of IN cord-005453-4057qib7 6275 11 collecting collect VBG cord-005453-4057qib7 6275 12 sufficient sufficient JJ cord-005453-4057qib7 6275 13 MNC MNC NNP cord-005453-4057qib7 6275 14 and and CC cord-005453-4057qib7 6275 15 irradiating irradiate VBG cord-005453-4057qib7 6275 16 the the DT cord-005453-4057qib7 6275 17 cells cell NNS cord-005453-4057qib7 6275 18 producing produce VBG cord-005453-4057qib7 6275 19 high high JJ cord-005453-4057qib7 6275 20 lymphocyte lymphocyte NN cord-005453-4057qib7 6275 21 apoptosis apoptosis NN cord-005453-4057qib7 6275 22 , , , cord-005453-4057qib7 6275 23 with with IN cord-005453-4057qib7 6275 24 minimal minimal JJ cord-005453-4057qib7 6275 25 alarms alarm NNS cord-005453-4057qib7 6275 26 and and CC cord-005453-4057qib7 6275 27 adverse adverse JJ cord-005453-4057qib7 6275 28 reactions reaction NNS cord-005453-4057qib7 6275 29 . . . cord-005453-4057qib7 6276 1 ( ( -LRB- cord-005453-4057qib7 6276 2 21.4 21.4 CD cord-005453-4057qib7 6276 3 % % NN cord-005453-4057qib7 6276 4 ) ) -RRB- cord-005453-4057qib7 6276 5 ) ) -RRB- cord-005453-4057qib7 6276 6 . . . cord-005453-4057qib7 6277 1 10 10 CD cord-005453-4057qib7 6277 2 ( ( -LRB- cord-005453-4057qib7 6277 3 23.8 23.8 CD cord-005453-4057qib7 6277 4 % % NN cord-005453-4057qib7 6277 5 ) ) -RRB- cord-005453-4057qib7 6277 6 of of IN cord-005453-4057qib7 6277 7 the the DT cord-005453-4057qib7 6277 8 42 42 CD cord-005453-4057qib7 6277 9 patients patient NNS cord-005453-4057qib7 6277 10 also also RB cord-005453-4057qib7 6277 11 had have VBD cord-005453-4057qib7 6277 12 acute acute JJ cord-005453-4057qib7 6277 13 GVHD GVHD NNP cord-005453-4057qib7 6277 14 of of IN cord-005453-4057qib7 6277 15 the the DT cord-005453-4057qib7 6277 16 skin skin NN cord-005453-4057qib7 6277 17 or or CC cord-005453-4057qib7 6277 18 Liver liver NN cord-005453-4057qib7 6277 19 . . . cord-005453-4057qib7 6278 1 37 37 CD cord-005453-4057qib7 6278 2 patients patient NNS cord-005453-4057qib7 6278 3 ( ( -LRB- cord-005453-4057qib7 6278 4 88.09 88.09 CD cord-005453-4057qib7 6278 5 % % NN cord-005453-4057qib7 6278 6 ) ) -RRB- cord-005453-4057qib7 6278 7 could could MD cord-005453-4057qib7 6278 8 be be VB cord-005453-4057qib7 6278 9 treated treat VBN cord-005453-4057qib7 6278 10 and and CC cord-005453-4057qib7 6278 11 controlled control VBN cord-005453-4057qib7 6278 12 with with IN cord-005453-4057qib7 6278 13 Methyl methyl NN cord-005453-4057qib7 6278 14 - - HYPH cord-005453-4057qib7 6278 15 prednislone prednislone NN cord-005453-4057qib7 6278 16 monotherapy monotherapy NN cord-005453-4057qib7 6278 17 , , , cord-005453-4057qib7 6278 18 5 5 CD cord-005453-4057qib7 6278 19 patients patient NNS cord-005453-4057qib7 6278 20 had have VBD cord-005453-4057qib7 6278 21 steroid steroid JJ cord-005453-4057qib7 6278 22 refractory refractory JJ cord-005453-4057qib7 6278 23 GVHD GVHD NNP cord-005453-4057qib7 6278 24 of of IN cord-005453-4057qib7 6278 25 whom whom WP cord-005453-4057qib7 6278 26 3 3 CD cord-005453-4057qib7 6278 27 patients patient NNS cord-005453-4057qib7 6278 28 ( ( -LRB- cord-005453-4057qib7 6278 29 7.14 7.14 CD cord-005453-4057qib7 6278 30 % % NN cord-005453-4057qib7 6278 31 ) ) -RRB- cord-005453-4057qib7 6278 32 could could MD cord-005453-4057qib7 6278 33 be be VB cord-005453-4057qib7 6278 34 salvaged salvage VBN cord-005453-4057qib7 6278 35 with with IN cord-005453-4057qib7 6278 36 additional additional JJ cord-005453-4057qib7 6278 37 drugs drug NNS cord-005453-4057qib7 6278 38 ( ( -LRB- cord-005453-4057qib7 6278 39 Infliximab:2 infliximab:2 NN cord-005453-4057qib7 6278 40 ; ; : cord-005453-4057qib7 6278 41 Tacrolimus:1 Tacrolimus:1 NNP cord-005453-4057qib7 6278 42 ) ) -RRB- cord-005453-4057qib7 6278 43 ; ; : cord-005453-4057qib7 6278 44 2 2 CD cord-005453-4057qib7 6278 45 patients patient NNS cord-005453-4057qib7 6278 46 ( ( -LRB- cord-005453-4057qib7 6278 47 4.77 4.77 CD cord-005453-4057qib7 6278 48 % % NN cord-005453-4057qib7 6278 49 ) ) -RRB- cord-005453-4057qib7 6278 50 had have VBD cord-005453-4057qib7 6278 51 refractory refractory JJ cord-005453-4057qib7 6278 52 acute acute JJ cord-005453-4057qib7 6278 53 Gut Gut NNP cord-005453-4057qib7 6278 54 GVHD GVHD NNP cord-005453-4057qib7 6278 55 and and CC cord-005453-4057qib7 6278 56 could could MD cord-005453-4057qib7 6278 57 not not RB cord-005453-4057qib7 6278 58 be be VB cord-005453-4057qib7 6278 59 salvaged salvage VBN cord-005453-4057qib7 6278 60 despite despite IN cord-005453-4057qib7 6278 61 more more JJR cord-005453-4057qib7 6278 62 than than IN cord-005453-4057qib7 6278 63 three three CD cord-005453-4057qib7 6278 64 lines line NNS cord-005453-4057qib7 6278 65 of of IN cord-005453-4057qib7 6278 66 therapy therapy NN cord-005453-4057qib7 6278 67 . . . cord-005453-4057qib7 6279 1 At at IN cord-005453-4057qib7 6279 2 the the DT cord-005453-4057qib7 6279 3 time time NN cord-005453-4057qib7 6279 4 of of IN cord-005453-4057qib7 6279 5 reporting reporting NN cord-005453-4057qib7 6279 6 , , , cord-005453-4057qib7 6279 7 26 26 CD cord-005453-4057qib7 6279 8 patients patient NNS cord-005453-4057qib7 6279 9 ( ( -LRB- cord-005453-4057qib7 6279 10 61.9 61.9 CD cord-005453-4057qib7 6279 11 % % NN cord-005453-4057qib7 6279 12 ) ) -RRB- cord-005453-4057qib7 6279 13 of of IN cord-005453-4057qib7 6279 14 the the DT cord-005453-4057qib7 6279 15 42 42 CD cord-005453-4057qib7 6279 16 are be VBP cord-005453-4057qib7 6279 17 alive alive JJ cord-005453-4057qib7 6279 18 . . . cord-005453-4057qib7 6280 1 11 11 CD cord-005453-4057qib7 6280 2 patients patient NNS cord-005453-4057qib7 6280 3 died die VBD cord-005453-4057qib7 6280 4 due due JJ cord-005453-4057qib7 6280 5 to to IN cord-005453-4057qib7 6280 6 transplant transplant NN cord-005453-4057qib7 6280 7 related relate VBN cord-005453-4057qib7 6280 8 mortality mortality NN cord-005453-4057qib7 6280 9 , , , cord-005453-4057qib7 6280 10 while while IN cord-005453-4057qib7 6280 11 5 5 CD cord-005453-4057qib7 6280 12 patients patient NNS cord-005453-4057qib7 6280 13 developed develop VBD cord-005453-4057qib7 6280 14 relapsed relapsed JJ cord-005453-4057qib7 6280 15 disease disease NN cord-005453-4057qib7 6280 16 . . . cord-005453-4057qib7 6281 1 On on IN cord-005453-4057qib7 6281 2 binary binary JJ cord-005453-4057qib7 6281 3 logistic logistic JJ cord-005453-4057qib7 6281 4 regression regression NN cord-005453-4057qib7 6281 5 analysis analysis NN cord-005453-4057qib7 6281 6 , , , cord-005453-4057qib7 6281 7 no no DT cord-005453-4057qib7 6281 8 baseline baseline JJ cord-005453-4057qib7 6281 9 clinical clinical JJ cord-005453-4057qib7 6281 10 or or CC cord-005453-4057qib7 6281 11 treatment treatment NN cord-005453-4057qib7 6281 12 related related JJ cord-005453-4057qib7 6281 13 predictor predictor NN cord-005453-4057qib7 6281 14 ( ( -LRB- cord-005453-4057qib7 6281 15 Disease Disease NNP cord-005453-4057qib7 6281 16 indication indication NN cord-005453-4057qib7 6281 17 , , , cord-005453-4057qib7 6281 18 Disease Disease NNP cord-005453-4057qib7 6281 19 status status NN cord-005453-4057qib7 6281 20 at at IN cord-005453-4057qib7 6281 21 transplant transplant NN cord-005453-4057qib7 6281 22 , , , cord-005453-4057qib7 6281 23 Transplant Transplant NNP cord-005453-4057qib7 6281 24 Type type NN cord-005453-4057qib7 6281 25 , , , cord-005453-4057qib7 6281 26 Graft Graft NNP cord-005453-4057qib7 6281 27 Source source NN cord-005453-4057qib7 6281 28 , , , cord-005453-4057qib7 6281 29 Type type NN cord-005453-4057qib7 6281 30 of of IN cord-005453-4057qib7 6281 31 conditioning conditioning NN cord-005453-4057qib7 6281 32 ) ) -RRB- cord-005453-4057qib7 6281 33 could could MD cord-005453-4057qib7 6281 34 be be VB cord-005453-4057qib7 6281 35 identified identify VBN cord-005453-4057qib7 6281 36 for for IN cord-005453-4057qib7 6281 37 developing develop VBG cord-005453-4057qib7 6281 38 acute acute JJ cord-005453-4057qib7 6281 39 GVHD GVHD NNP cord-005453-4057qib7 6281 40 of of IN cord-005453-4057qib7 6281 41 the the DT cord-005453-4057qib7 6281 42 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 6281 43 system system NN cord-005453-4057qib7 6281 44 . . . cord-005453-4057qib7 6282 1 Conclusions conclusion NNS cord-005453-4057qib7 6282 2 : : : cord-005453-4057qib7 6283 1 Acute acute JJ cord-005453-4057qib7 6283 2 GVHD GVHD NNP cord-005453-4057qib7 6283 3 of of IN cord-005453-4057qib7 6283 4 the the DT cord-005453-4057qib7 6283 5 Gastro gastro JJ cord-005453-4057qib7 6283 6 - - HYPH cord-005453-4057qib7 6283 7 intestinal intestinal JJ cord-005453-4057qib7 6283 8 system system NN cord-005453-4057qib7 6283 9 is be VBZ cord-005453-4057qib7 6283 10 a a DT cord-005453-4057qib7 6283 11 significant significant JJ cord-005453-4057qib7 6283 12 cause cause NN cord-005453-4057qib7 6283 13 for for IN cord-005453-4057qib7 6283 14 morbidity morbidity NN cord-005453-4057qib7 6283 15 in in IN cord-005453-4057qib7 6283 16 Allo Allo NNP cord-005453-4057qib7 6283 17 - - HYPH cord-005453-4057qib7 6283 18 HCT hct NN cord-005453-4057qib7 6283 19 patients patient NNS cord-005453-4057qib7 6283 20 at at IN cord-005453-4057qib7 6283 21 our -PRON- PRP$ cord-005453-4057qib7 6283 22 centre centre NN cord-005453-4057qib7 6283 23 . . . cord-005453-4057qib7 6284 1 Further further JJ cord-005453-4057qib7 6284 2 studies study NNS cord-005453-4057qib7 6284 3 are be VBP cord-005453-4057qib7 6284 4 warranted warrant VBN cord-005453-4057qib7 6284 5 in in IN cord-005453-4057qib7 6284 6 our -PRON- PRP$ cord-005453-4057qib7 6284 7 cohort cohort NN cord-005453-4057qib7 6284 8 , , , cord-005453-4057qib7 6284 9 and and CC cord-005453-4057qib7 6284 10 a a DT cord-005453-4057qib7 6284 11 prospective prospective JJ cord-005453-4057qib7 6284 12 analysis analysis NN cord-005453-4057qib7 6284 13 of of IN cord-005453-4057qib7 6284 14 gut gut NN cord-005453-4057qib7 6284 15 microbiome microbiome NN cord-005453-4057qib7 6284 16 analysis analysis NN cord-005453-4057qib7 6284 17 , , , cord-005453-4057qib7 6284 18 faecal faecal JJ cord-005453-4057qib7 6284 19 multi multi JJ cord-005453-4057qib7 6284 20 - - JJ cord-005453-4057qib7 6284 21 drug drug JJ cord-005453-4057qib7 6284 22 resistance resistance NN cord-005453-4057qib7 6284 23 organism organism NN cord-005453-4057qib7 6284 24 surveillance surveillance NN cord-005453-4057qib7 6284 25 , , , cord-005453-4057qib7 6284 26 conditioning conditioning NN cord-005453-4057qib7 6284 27 related relate VBN cord-005453-4057qib7 6284 28 toxicity toxicity NN cord-005453-4057qib7 6284 29 and and CC cord-005453-4057qib7 6284 30 antibiotic antibiotic JJ cord-005453-4057qib7 6284 31 usage usage NN cord-005453-4057qib7 6284 32 is be VBZ cord-005453-4057qib7 6284 33 ongoing ongoing JJ cord-005453-4057qib7 6284 34 . . . cord-005453-4057qib7 6285 1 Clinical clinical JJ cord-005453-4057qib7 6285 2 Trial Trial NNP cord-005453-4057qib7 6285 3 Registry Registry NNP cord-005453-4057qib7 6285 4 : : : cord-005453-4057qib7 6286 1 Not not RB cord-005453-4057qib7 6286 2 applicable applicable JJ cord-005453-4057qib7 6286 3 Disclosure disclosure NN cord-005453-4057qib7 6286 4 : : : cord-005453-4057qib7 6287 1 The the DT cord-005453-4057qib7 6287 2 authors author NNS cord-005453-4057qib7 6287 3 declare declare VBP cord-005453-4057qib7 6287 4 no no DT cord-005453-4057qib7 6287 5 potential potential JJ cord-005453-4057qib7 6287 6 conflicts conflict NNS cord-005453-4057qib7 6287 7 of of IN cord-005453-4057qib7 6287 8 interest interest NN cord-005453-4057qib7 6287 9 Benefits benefit NNS cord-005453-4057qib7 6287 10 and and CC cord-005453-4057qib7 6287 11 precautions precaution NNS cord-005453-4057qib7 6287 12 of of IN cord-005453-4057qib7 6287 13 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6287 14 in in IN cord-005453-4057qib7 6287 15 steroidrefractory steroidrefractory NNP cord-005453-4057qib7 6287 16 acute acute JJ cord-005453-4057qib7 6287 17 GVHD GVHD NNP cord-005453-4057qib7 6287 18 Background Background NNP cord-005453-4057qib7 6287 19 : : : cord-005453-4057qib7 6288 1 Corticosteroids corticosteroid NNS cord-005453-4057qib7 6288 2 are be VBP cord-005453-4057qib7 6288 3 the the DT cord-005453-4057qib7 6288 4 standard standard JJ cord-005453-4057qib7 6288 5 first first JJ cord-005453-4057qib7 6288 6 - - HYPH cord-005453-4057qib7 6288 7 line line NN cord-005453-4057qib7 6288 8 treatment treatment NN cord-005453-4057qib7 6288 9 option option NN cord-005453-4057qib7 6288 10 for for IN cord-005453-4057qib7 6288 11 patients patient NNS cord-005453-4057qib7 6288 12 with with IN cord-005453-4057qib7 6288 13 acute acute JJ cord-005453-4057qib7 6288 14 graft graft NN cord-005453-4057qib7 6288 15 - - HYPH cord-005453-4057qib7 6288 16 versus versus IN cord-005453-4057qib7 6288 17 host host NN cord-005453-4057qib7 6288 18 disease disease NN cord-005453-4057qib7 6288 19 ( ( -LRB- cord-005453-4057qib7 6288 20 GVHD GVHD NNP cord-005453-4057qib7 6288 21 ) ) -RRB- cord-005453-4057qib7 6288 22 , , , cord-005453-4057qib7 6288 23 but but CC cord-005453-4057qib7 6288 24 approximately approximately RB cord-005453-4057qib7 6288 25 half half NN cord-005453-4057qib7 6288 26 of of IN cord-005453-4057qib7 6288 27 patients patient NNS cord-005453-4057qib7 6288 28 become become VBP cord-005453-4057qib7 6288 29 refractory refractory JJ cord-005453-4057qib7 6288 30 to to IN cord-005453-4057qib7 6288 31 steroids steroid NNS cord-005453-4057qib7 6288 32 and and CC cord-005453-4057qib7 6288 33 require require VB cord-005453-4057qib7 6288 34 second second JJ cord-005453-4057qib7 6288 35 - - HYPH cord-005453-4057qib7 6288 36 line line NN cord-005453-4057qib7 6288 37 treatment treatment NN cord-005453-4057qib7 6288 38 . . . cord-005453-4057qib7 6289 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 6289 2 has have VBZ cord-005453-4057qib7 6289 3 the the DT cord-005453-4057qib7 6289 4 potential potential NN cord-005453-4057qib7 6289 5 to to TO cord-005453-4057qib7 6289 6 treat treat VB cord-005453-4057qib7 6289 7 GVHD GVHD NNP cord-005453-4057qib7 6289 8 in in IN cord-005453-4057qib7 6289 9 steroidrefractory steroidrefractory NNP cord-005453-4057qib7 6289 10 ( ( -LRB- cord-005453-4057qib7 6289 11 SR SR NNP cord-005453-4057qib7 6289 12 ) ) -RRB- cord-005453-4057qib7 6289 13 patients patient NNS cord-005453-4057qib7 6289 14 based base VBN cord-005453-4057qib7 6289 15 on on IN cord-005453-4057qib7 6289 16 retrospective retrospective JJ cord-005453-4057qib7 6289 17 clinical clinical JJ cord-005453-4057qib7 6289 18 data datum NNS cord-005453-4057qib7 6289 19 . . . cord-005453-4057qib7 6290 1 The the DT cord-005453-4057qib7 6290 2 ongoing ongoing JJ cord-005453-4057qib7 6290 3 prospective prospective JJ cord-005453-4057qib7 6290 4 trials trial NNS cord-005453-4057qib7 6290 5 are be VBP cord-005453-4057qib7 6290 6 currently currently RB cord-005453-4057qib7 6290 7 enrolling enrol VBG cord-005453-4057qib7 6290 8 patients patient NNS cord-005453-4057qib7 6290 9 to to TO cord-005453-4057qib7 6290 10 evaluate evaluate VB cord-005453-4057qib7 6290 11 the the DT cord-005453-4057qib7 6290 12 therapeutic therapeutic JJ cord-005453-4057qib7 6290 13 potential potential NN cord-005453-4057qib7 6290 14 of of IN cord-005453-4057qib7 6290 15 ruxolitinib ruxolitinib NN cord-005453-4057qib7 6290 16 for for IN cord-005453-4057qib7 6290 17 GVHD GVHD NNP cord-005453-4057qib7 6290 18 . . . cord-005453-4057qib7 6291 1 Methods method NNS cord-005453-4057qib7 6291 2 : : : cord-005453-4057qib7 6292 1 We -PRON- PRP cord-005453-4057qib7 6292 2 analyzed analyze VBD cord-005453-4057qib7 6292 3 retrospectively retrospectively RB cord-005453-4057qib7 6292 4 clinical clinical JJ cord-005453-4057qib7 6292 5 experience experience NN cord-005453-4057qib7 6292 6 with with IN cord-005453-4057qib7 6292 7 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6292 8 in in IN cord-005453-4057qib7 6292 9 patients patient NNS cord-005453-4057qib7 6292 10 ( ( -LRB- cord-005453-4057qib7 6292 11 n=15 n=15 NNP cord-005453-4057qib7 6292 12 ) ) -RRB- cord-005453-4057qib7 6292 13 with with IN cord-005453-4057qib7 6292 14 grade grade NN cord-005453-4057qib7 6292 15 2~4 2~4 CD cord-005453-4057qib7 6292 16 steroid steroid JJ cord-005453-4057qib7 6292 17 - - HYPH cord-005453-4057qib7 6292 18 refractory refractory JJ cord-005453-4057qib7 6292 19 acute acute JJ cord-005453-4057qib7 6292 20 GVHD GVHD NNP cord-005453-4057qib7 6292 21 patients patient NNS cord-005453-4057qib7 6292 22 compared compare VBN cord-005453-4057qib7 6292 23 with with IN cord-005453-4057qib7 6292 24 the the DT cord-005453-4057qib7 6292 25 control control NN cord-005453-4057qib7 6292 26 group group NN cord-005453-4057qib7 6292 27 not not RB cord-005453-4057qib7 6292 28 receiving receive VBG cord-005453-4057qib7 6292 29 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6292 30 . . . cord-005453-4057qib7 6293 1 In in IN cord-005453-4057qib7 6293 2 addition addition NN cord-005453-4057qib7 6293 3 , , , cord-005453-4057qib7 6293 4 immune immune JJ cord-005453-4057qib7 6293 5 status status NN cord-005453-4057qib7 6293 6 was be VBD cord-005453-4057qib7 6293 7 evaluated evaluate VBN cord-005453-4057qib7 6293 8 about about IN cord-005453-4057qib7 6293 9 6 6 CD cord-005453-4057qib7 6293 10 weeks~8 weeks~8 NNP cord-005453-4057qib7 6293 11 weeks week NNS cord-005453-4057qib7 6293 12 after after IN cord-005453-4057qib7 6293 13 the the DT cord-005453-4057qib7 6293 14 administration administration NN cord-005453-4057qib7 6293 15 of of IN cord-005453-4057qib7 6293 16 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6293 17 using use VBG cord-005453-4057qib7 6293 18 flow flow NN cord-005453-4057qib7 6293 19 - - HYPH cord-005453-4057qib7 6293 20 cytometry cytometry NN cord-005453-4057qib7 6293 21 . . . cord-005453-4057qib7 6294 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 6294 2 was be VBD cord-005453-4057qib7 6294 3 used use VBN cord-005453-4057qib7 6294 4 as as IN cord-005453-4057qib7 6294 5 a a DT cord-005453-4057qib7 6294 6 third third JJ cord-005453-4057qib7 6294 7 option option NN cord-005453-4057qib7 6294 8 for for IN cord-005453-4057qib7 6294 9 SR SR NNP cord-005453-4057qib7 6294 10 GVHD GVHD NNP cord-005453-4057qib7 6294 11 , , , cord-005453-4057qib7 6294 12 combined combine VBN cord-005453-4057qib7 6294 13 with with IN cord-005453-4057qib7 6294 14 previously previously RB cord-005453-4057qib7 6294 15 used use VBN cord-005453-4057qib7 6294 16 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6294 17 drugs drug NNS cord-005453-4057qib7 6294 18 . . . cord-005453-4057qib7 6295 1 And and CC cord-005453-4057qib7 6295 2 steroids steroid NNS cord-005453-4057qib7 6295 3 were be VBD cord-005453-4057qib7 6295 4 gradually gradually RB cord-005453-4057qib7 6295 5 decreased decrease VBN cord-005453-4057qib7 6295 6 according accord VBG cord-005453-4057qib7 6295 7 to to IN cord-005453-4057qib7 6295 8 the the DT cord-005453-4057qib7 6295 9 symptoms symptom NNS cord-005453-4057qib7 6295 10 and and CC cord-005453-4057qib7 6295 11 discontinued discontinue VBD cord-005453-4057qib7 6295 12 . . . cord-005453-4057qib7 6296 1 Patients patient NNS cord-005453-4057qib7 6296 2 received receive VBD cord-005453-4057qib7 6296 3 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6296 4 5 5 CD cord-005453-4057qib7 6296 5 mg mg NNP cord-005453-4057qib7 6296 6 twice twice RB cord-005453-4057qib7 6296 7 daily daily RB cord-005453-4057qib7 6296 8 ( ( -LRB- cord-005453-4057qib7 6296 9 BID BID NNP cord-005453-4057qib7 6296 10 ) ) -RRB- cord-005453-4057qib7 6296 11 , , , cord-005453-4057qib7 6296 12 with with IN cord-005453-4057qib7 6296 13 increase increase NN cord-005453-4057qib7 6296 14 to to IN cord-005453-4057qib7 6296 15 10 10 CD cord-005453-4057qib7 6296 16 mg mg NN cord-005453-4057qib7 6296 17 BID BID NNP cord-005453-4057qib7 6296 18 if if IN cord-005453-4057qib7 6296 19 hematologic hematologic JJ cord-005453-4057qib7 6296 20 parameters parameter NNS cord-005453-4057qib7 6296 21 are be VBP cord-005453-4057qib7 6296 22 stable stable JJ cord-005453-4057qib7 6296 23 and and CC cord-005453-4057qib7 6296 24 no no DT cord-005453-4057qib7 6296 25 treatmentrelated treatmentrelate VBN cord-005453-4057qib7 6296 26 toxicities toxicity NNS cord-005453-4057qib7 6296 27 . . . cord-005453-4057qib7 6297 1 Results result NNS cord-005453-4057qib7 6297 2 : : : cord-005453-4057qib7 6298 1 Fifteen fifteen CD cord-005453-4057qib7 6298 2 patients patient NNS cord-005453-4057qib7 6298 3 all all DT cord-005453-4057qib7 6298 4 were be VBD cord-005453-4057qib7 6298 5 assessable assessable JJ cord-005453-4057qib7 6298 6 for for IN cord-005453-4057qib7 6298 7 response response NN cord-005453-4057qib7 6298 8 . . . cord-005453-4057qib7 6299 1 Seven seven CD cord-005453-4057qib7 6299 2 patients patient NNS cord-005453-4057qib7 6299 3 achieved achieve VBD cord-005453-4057qib7 6299 4 a a DT cord-005453-4057qib7 6299 5 complete complete JJ cord-005453-4057qib7 6299 6 response response NN cord-005453-4057qib7 6299 7 , , , cord-005453-4057qib7 6299 8 5 5 CD cord-005453-4057qib7 6299 9 had have VBD cord-005453-4057qib7 6299 10 a a DT cord-005453-4057qib7 6299 11 partial partial JJ cord-005453-4057qib7 6299 12 response response NN cord-005453-4057qib7 6299 13 , , , cord-005453-4057qib7 6299 14 and and CC cord-005453-4057qib7 6299 15 3 3 CD cord-005453-4057qib7 6299 16 had have VBD cord-005453-4057qib7 6299 17 no no DT cord-005453-4057qib7 6299 18 response response NN cord-005453-4057qib7 6299 19 at at IN cord-005453-4057qib7 6299 20 8 8 CD cord-005453-4057qib7 6299 21 weeks week NNS cord-005453-4057qib7 6299 22 after after IN cord-005453-4057qib7 6299 23 the the DT cord-005453-4057qib7 6299 24 first first JJ cord-005453-4057qib7 6299 25 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6299 26 dose dose NN cord-005453-4057qib7 6299 27 . . . cord-005453-4057qib7 6300 1 Overall overall JJ cord-005453-4057qib7 6300 2 response response NN cord-005453-4057qib7 6300 3 rate rate NN cord-005453-4057qib7 6300 4 was be VBD cord-005453-4057qib7 6300 5 75 75 CD cord-005453-4057qib7 6300 6 % % NN cord-005453-4057qib7 6300 7 . . . cord-005453-4057qib7 6301 1 Three three CD cord-005453-4057qib7 6301 2 were be VBD cord-005453-4057qib7 6301 3 treatment treatment NN cord-005453-4057qib7 6301 4 failures failure NNS cord-005453-4057qib7 6301 5 . . . cord-005453-4057qib7 6302 1 Most Most JJS cord-005453-4057qib7 6302 2 adverse adverse JJ cord-005453-4057qib7 6302 3 effects effect NNS cord-005453-4057qib7 6302 4 were be VBD cord-005453-4057qib7 6302 5 manageable manageable JJ cord-005453-4057qib7 6302 6 , , , cord-005453-4057qib7 6302 7 except except IN cord-005453-4057qib7 6302 8 infectious infectious JJ cord-005453-4057qib7 6302 9 complications complication NNS cord-005453-4057qib7 6302 10 . . . cord-005453-4057qib7 6303 1 Infectious infectious JJ cord-005453-4057qib7 6303 2 complications complication NNS cord-005453-4057qib7 6303 3 were be VBD cord-005453-4057qib7 6303 4 occurred occur VBN cord-005453-4057qib7 6303 5 in in IN cord-005453-4057qib7 6303 6 about about RB cord-005453-4057qib7 6303 7 73 73 CD cord-005453-4057qib7 6303 8 % % NN cord-005453-4057qib7 6303 9 patients patient NNS cord-005453-4057qib7 6303 10 ( ( -LRB- cord-005453-4057qib7 6303 11 n n NN cord-005453-4057qib7 6303 12 = = SYM cord-005453-4057qib7 6303 13 11 11 CD cord-005453-4057qib7 6303 14 ) ) -RRB- cord-005453-4057qib7 6303 15 , , , cord-005453-4057qib7 6303 16 resulting result VBG cord-005453-4057qib7 6303 17 in in IN cord-005453-4057qib7 6303 18 two two CD cord-005453-4057qib7 6303 19 deaths death NNS cord-005453-4057qib7 6303 20 . . . cord-005453-4057qib7 6304 1 Common common JJ cord-005453-4057qib7 6304 2 cause cause NN cord-005453-4057qib7 6304 3 of of IN cord-005453-4057qib7 6304 4 infectious infectious JJ cord-005453-4057qib7 6304 5 events event NNS cord-005453-4057qib7 6304 6 included include VBD cord-005453-4057qib7 6304 7 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 6304 8 ( ( -LRB- cord-005453-4057qib7 6304 9 n n NN cord-005453-4057qib7 6304 10 = = SYM cord-005453-4057qib7 6304 11 5 5 CD cord-005453-4057qib7 6304 12 ) ) -RRB- cord-005453-4057qib7 6304 13 , , , cord-005453-4057qib7 6304 14 herpes herpes NN cord-005453-4057qib7 6304 15 - - HYPH cord-005453-4057qib7 6304 16 zoster zoster NN cord-005453-4057qib7 6304 17 ( ( -LRB- cord-005453-4057qib7 6304 18 n=2 n=2 NNS cord-005453-4057qib7 6304 19 ) ) -RRB- cord-005453-4057qib7 6304 20 , , , cord-005453-4057qib7 6304 21 Epstein Epstein NNP cord-005453-4057qib7 6304 22 - - HYPH cord-005453-4057qib7 6304 23 Barr Barr NNP cord-005453-4057qib7 6304 24 virus virus NN cord-005453-4057qib7 6304 25 ( ( -LRB- cord-005453-4057qib7 6304 26 n=2 n=2 NNS cord-005453-4057qib7 6304 27 ) ) -RRB- cord-005453-4057qib7 6304 28 , , , cord-005453-4057qib7 6304 29 fungal fungal JJ cord-005453-4057qib7 6304 30 infection infection NN cord-005453-4057qib7 6305 1 ( ( -LRB- cord-005453-4057qib7 6305 2 n n NN cord-005453-4057qib7 6305 3 = = SYM cord-005453-4057qib7 6305 4 2 2 CD cord-005453-4057qib7 6305 5 ) ) -RRB- cord-005453-4057qib7 6305 6 , , , cord-005453-4057qib7 6305 7 pneumocystis pneumocystis NNP cord-005453-4057qib7 6305 8 jiroveci jiroveci NNP cord-005453-4057qib7 6305 9 ( ( -LRB- cord-005453-4057qib7 6305 10 n n NN cord-005453-4057qib7 6305 11 = = SYM cord-005453-4057qib7 6305 12 2 2 CD cord-005453-4057qib7 6305 13 ) ) -RRB- cord-005453-4057qib7 6305 14 , , , cord-005453-4057qib7 6305 15 bacterial bacterial JJ cord-005453-4057qib7 6305 16 infections infection NNS cord-005453-4057qib7 6305 17 ( ( -LRB- cord-005453-4057qib7 6305 18 n n NN cord-005453-4057qib7 6305 19 = = SYM cord-005453-4057qib7 6305 20 1 1 CD cord-005453-4057qib7 6305 21 ) ) -RRB- cord-005453-4057qib7 6305 22 , , , cord-005453-4057qib7 6305 23 and and CC cord-005453-4057qib7 6305 24 pneumonia pneumonia NN cord-005453-4057qib7 6305 25 of of IN cord-005453-4057qib7 6305 26 unknown unknown JJ cord-005453-4057qib7 6305 27 origin origin NN cord-005453-4057qib7 6305 28 ( ( -LRB- cord-005453-4057qib7 6305 29 n n NN cord-005453-4057qib7 6305 30 = = SYM cord-005453-4057qib7 6305 31 1 1 CD cord-005453-4057qib7 6305 32 ) ) -RRB- cord-005453-4057qib7 6305 33 . . . cord-005453-4057qib7 6306 1 T T NNP cord-005453-4057qib7 6306 2 cell cell NN cord-005453-4057qib7 6306 3 counts count NNS cord-005453-4057qib7 6306 4 tended tend VBD cord-005453-4057qib7 6306 5 to to TO cord-005453-4057qib7 6306 6 decreased decrease VBD cord-005453-4057qib7 6306 7 in in IN cord-005453-4057qib7 6306 8 the the DT cord-005453-4057qib7 6306 9 group group NN cord-005453-4057qib7 6306 10 with with IN cord-005453-4057qib7 6306 11 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6306 12 compared compare VBN cord-005453-4057qib7 6306 13 with with IN cord-005453-4057qib7 6306 14 the the DT cord-005453-4057qib7 6306 15 control control NN cord-005453-4057qib7 6306 16 group group NN cord-005453-4057qib7 6306 17 , , , cord-005453-4057qib7 6306 18 especially especially RB cord-005453-4057qib7 6306 19 CD4 CD4 NNP cord-005453-4057qib7 6306 20 cell cell NN cord-005453-4057qib7 6306 21 counts count VBZ cord-005453-4057qib7 6306 22 . . . cord-005453-4057qib7 6307 1 Conclusions conclusion NNS cord-005453-4057qib7 6307 2 : : : cord-005453-4057qib7 6308 1 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 6308 2 is be VBZ cord-005453-4057qib7 6308 3 effective effective JJ cord-005453-4057qib7 6308 4 in in IN cord-005453-4057qib7 6308 5 controlling control VBG cord-005453-4057qib7 6308 6 SR SR NNP cord-005453-4057qib7 6308 7 GVHD GVHD NNP cord-005453-4057qib7 6308 8 and and CC cord-005453-4057qib7 6308 9 can can MD cord-005453-4057qib7 6308 10 lead lead VB cord-005453-4057qib7 6308 11 to to IN cord-005453-4057qib7 6308 12 clinical clinical JJ cord-005453-4057qib7 6308 13 benefits benefit NNS cord-005453-4057qib7 6308 14 . . . cord-005453-4057qib7 6309 1 However however RB cord-005453-4057qib7 6309 2 , , , cord-005453-4057qib7 6309 3 we -PRON- PRP cord-005453-4057qib7 6309 4 need need VBP cord-005453-4057qib7 6309 5 to to TO cord-005453-4057qib7 6309 6 be be VB cord-005453-4057qib7 6309 7 aware aware JJ cord-005453-4057qib7 6309 8 of of IN cord-005453-4057qib7 6309 9 the the DT cord-005453-4057qib7 6309 10 infectious infectious JJ cord-005453-4057qib7 6309 11 complications complication NNS cord-005453-4057qib7 6309 12 because because IN cord-005453-4057qib7 6309 13 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6309 14 may may MD cord-005453-4057qib7 6309 15 lead lead VB cord-005453-4057qib7 6309 16 to to IN cord-005453-4057qib7 6309 17 increased increase VBN cord-005453-4057qib7 6309 18 risk risk NN cord-005453-4057qib7 6309 19 of of IN cord-005453-4057qib7 6309 20 opportunistic opportunistic JJ cord-005453-4057qib7 6309 21 infections infection NNS cord-005453-4057qib7 6309 22 or or CC cord-005453-4057qib7 6309 23 reactivation reactivation NN cord-005453-4057qib7 6309 24 of of IN cord-005453-4057qib7 6309 25 latent latent JJ cord-005453-4057qib7 6309 26 infections infection NNS cord-005453-4057qib7 6309 27 . . . cord-005453-4057qib7 6310 1 In in IN cord-005453-4057qib7 6310 2 addition addition NN cord-005453-4057qib7 6310 3 , , , cord-005453-4057qib7 6310 4 common common JJ cord-005453-4057qib7 6310 5 infectious infectious JJ cord-005453-4057qib7 6310 6 complications complication NNS cord-005453-4057qib7 6310 7 are be VBP cord-005453-4057qib7 6310 8 presumed presume VBN cord-005453-4057qib7 6310 9 to to TO cord-005453-4057qib7 6310 10 involve involve VB cord-005453-4057qib7 6310 11 T T NNP cord-005453-4057qib7 6310 12 cell cell NN cord-005453-4057qib7 6310 13 dysfunction dysfunction NN cord-005453-4057qib7 6310 14 . . . cord-005453-4057qib7 6311 1 Clinical clinical JJ cord-005453-4057qib7 6311 2 Background background NN cord-005453-4057qib7 6311 3 : : : cord-005453-4057qib7 6311 4 Graft graft NN cord-005453-4057qib7 6311 5 versus versus IN cord-005453-4057qib7 6311 6 host host NN cord-005453-4057qib7 6311 7 disease disease NN cord-005453-4057qib7 6311 8 ( ( -LRB- cord-005453-4057qib7 6311 9 GvHD GvHD NNP cord-005453-4057qib7 6311 10 ) ) -RRB- cord-005453-4057qib7 6311 11 , , , cord-005453-4057qib7 6311 12 being be VBG cord-005453-4057qib7 6311 13 one one CD cord-005453-4057qib7 6311 14 of of IN cord-005453-4057qib7 6311 15 most most JJS cord-005453-4057qib7 6311 16 common common JJ cord-005453-4057qib7 6311 17 life life NN cord-005453-4057qib7 6311 18 - - HYPH cord-005453-4057qib7 6311 19 threatening threaten VBG cord-005453-4057qib7 6311 20 complication complication NN cord-005453-4057qib7 6311 21 post post NN cord-005453-4057qib7 6311 22 HSCT HSCT NNP cord-005453-4057qib7 6311 23 , , , cord-005453-4057qib7 6311 24 contributes contribute VBZ cord-005453-4057qib7 6311 25 significantly significantly RB cord-005453-4057qib7 6311 26 to to IN cord-005453-4057qib7 6311 27 morbidity morbidity NN cord-005453-4057qib7 6311 28 and and CC cord-005453-4057qib7 6311 29 mortality mortality NN cord-005453-4057qib7 6311 30 . . . cord-005453-4057qib7 6312 1 When when WRB cord-005453-4057qib7 6312 2 affecting affect VBG cord-005453-4057qib7 6312 3 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 6312 4 tract tract NN cord-005453-4057qib7 6312 5 ( ( -LRB- cord-005453-4057qib7 6312 6 GI GI NNP cord-005453-4057qib7 6312 7 ) ) -RRB- cord-005453-4057qib7 6313 1 it -PRON- PRP cord-005453-4057qib7 6313 2 is be VBZ cord-005453-4057qib7 6313 3 the the DT cord-005453-4057qib7 6313 4 major major JJ cord-005453-4057qib7 6313 5 cause cause NN cord-005453-4057qib7 6313 6 of of IN cord-005453-4057qib7 6313 7 death death NN cord-005453-4057qib7 6313 8 in in IN cord-005453-4057qib7 6313 9 early early JJ cord-005453-4057qib7 6313 10 period period NN cord-005453-4057qib7 6313 11 post post NN cord-005453-4057qib7 6313 12 HSCT HSCT NNP cord-005453-4057qib7 6313 13 . . . cord-005453-4057qib7 6314 1 Due due IN cord-005453-4057qib7 6314 2 to to IN cord-005453-4057qib7 6314 3 widespread widespread JJ cord-005453-4057qib7 6314 4 tissue tissue NN cord-005453-4057qib7 6314 5 involvement involvement NN cord-005453-4057qib7 6314 6 in in IN cord-005453-4057qib7 6314 7 most most JJS cord-005453-4057qib7 6314 8 patients patient NNS cord-005453-4057qib7 6314 9 diagnosed diagnose VBN cord-005453-4057qib7 6314 10 with with IN cord-005453-4057qib7 6314 11 GI GI NNP cord-005453-4057qib7 6314 12 GvHD GvHD NNP cord-005453-4057qib7 6314 13 , , , cord-005453-4057qib7 6314 14 surgical surgical JJ cord-005453-4057qib7 6314 15 treatment treatment NN cord-005453-4057qib7 6314 16 is be VBZ cord-005453-4057qib7 6314 17 rarely rarely RB cord-005453-4057qib7 6314 18 considered consider VBN cord-005453-4057qib7 6314 19 . . . cord-005453-4057qib7 6315 1 Methods method NNS cord-005453-4057qib7 6315 2 : : : cord-005453-4057qib7 6316 1 Among among IN cord-005453-4057qib7 6316 2 972 972 CD cord-005453-4057qib7 6316 3 allo allo NN cord-005453-4057qib7 6316 4 - - HYPH cord-005453-4057qib7 6316 5 HSCT HSCT NNP cord-005453-4057qib7 6316 6 performed perform VBD cord-005453-4057qib7 6316 7 in in IN cord-005453-4057qib7 6316 8 Department Department NNP cord-005453-4057qib7 6316 9 of of IN cord-005453-4057qib7 6316 10 Pediatric Pediatric NNP cord-005453-4057qib7 6316 11 Hematology Hematology NNP cord-005453-4057qib7 6316 12 , , , cord-005453-4057qib7 6316 13 Oncology Oncology NNP cord-005453-4057qib7 6316 14 and and CC cord-005453-4057qib7 6316 15 Bone Bone NNP cord-005453-4057qib7 6316 16 Marrow Marrow NNP cord-005453-4057qib7 6316 17 Transplantation transplantation NN cord-005453-4057qib7 6316 18 in in IN cord-005453-4057qib7 6316 19 Wroclaw Wroclaw NNP cord-005453-4057qib7 6316 20 , , , cord-005453-4057qib7 6316 21 Poland Poland NNP cord-005453-4057qib7 6316 22 during during IN cord-005453-4057qib7 6316 23 years year NNS cord-005453-4057qib7 6316 24 1996 1996 CD cord-005453-4057qib7 6316 25 - - SYM cord-005453-4057qib7 6316 26 2018 2018 CD cord-005453-4057qib7 6316 27 , , , cord-005453-4057qib7 6316 28 291 291 CD cord-005453-4057qib7 6316 29 ( ( -LRB- cord-005453-4057qib7 6316 30 29,9 29,9 CD cord-005453-4057qib7 6316 31 % % NN cord-005453-4057qib7 6316 32 ) ) -RRB- cord-005453-4057qib7 6316 33 cases case NNS cord-005453-4057qib7 6316 34 were be VBD cord-005453-4057qib7 6316 35 diagnosed diagnose VBN cord-005453-4057qib7 6316 36 with with IN cord-005453-4057qib7 6316 37 GI GI NNP cord-005453-4057qib7 6316 38 GvHD GvHD NNP cord-005453-4057qib7 6316 39 . . . cord-005453-4057qib7 6317 1 In in IN cord-005453-4057qib7 6317 2 this this DT cord-005453-4057qib7 6317 3 study study NN cord-005453-4057qib7 6317 4 we -PRON- PRP cord-005453-4057qib7 6317 5 present present VBP cord-005453-4057qib7 6317 6 3 3 CD cord-005453-4057qib7 6317 7 cases case NNS cord-005453-4057qib7 6317 8 ( ( -LRB- cord-005453-4057qib7 6317 9 1 1 CD cord-005453-4057qib7 6317 10 % % NN cord-005453-4057qib7 6317 11 ) ) -RRB- cord-005453-4057qib7 6317 12 which which WDT cord-005453-4057qib7 6317 13 were be VBD cord-005453-4057qib7 6317 14 referred refer VBN cord-005453-4057qib7 6317 15 to to IN cord-005453-4057qib7 6317 16 and and CC cord-005453-4057qib7 6317 17 benefit benefit VB cord-005453-4057qib7 6317 18 from from IN cord-005453-4057qib7 6317 19 surgical surgical JJ cord-005453-4057qib7 6317 20 approach approach NN cord-005453-4057qib7 6317 21 . . . cord-005453-4057qib7 6318 1 Results result NNS cord-005453-4057qib7 6318 2 : : : cord-005453-4057qib7 6318 3 1 1 CD cord-005453-4057qib7 6318 4 . . . cord-005453-4057qib7 6319 1 Male male JJ cord-005453-4057qib7 6319 2 , , , cord-005453-4057qib7 6319 3 4 4 CD cord-005453-4057qib7 6319 4 years year NNS cord-005453-4057qib7 6319 5 old old JJ cord-005453-4057qib7 6319 6 underwent undergo VBD cord-005453-4057qib7 6319 7 HSCT HSCT NNP cord-005453-4057qib7 6319 8 from from IN cord-005453-4057qib7 6319 9 matched matched JJ cord-005453-4057qib7 6319 10 unrelated unrelated JJ cord-005453-4057qib7 6319 11 donor donor NN cord-005453-4057qib7 6319 12 ( ( -LRB- cord-005453-4057qib7 6319 13 MUD mud NN cord-005453-4057qib7 6319 14 ) ) -RRB- cord-005453-4057qib7 6319 15 due due IN cord-005453-4057qib7 6319 16 to to IN cord-005453-4057qib7 6319 17 chronic chronic JJ cord-005453-4057qib7 6319 18 myelogenous myelogenous NN cord-005453-4057qib7 6319 19 leukemia leukemia NN cord-005453-4057qib7 6319 20 ( ( -LRB- cord-005453-4057qib7 6319 21 CML CML NNP cord-005453-4057qib7 6319 22 ) ) -RRB- cord-005453-4057qib7 6319 23 and and CC cord-005453-4057qib7 6319 24 subsequent subsequent JJ cord-005453-4057qib7 6319 25 molecular molecular JJ cord-005453-4057qib7 6319 26 relapse relapse NN cord-005453-4057qib7 6319 27 succesfully succesfully RB cord-005453-4057qib7 6319 28 treated treat VBD cord-005453-4057qib7 6319 29 with with IN cord-005453-4057qib7 6319 30 donor donor NN cord-005453-4057qib7 6319 31 lymphocyte lymphocyte NN cord-005453-4057qib7 6319 32 infusion infusion NN cord-005453-4057qib7 6319 33 , , , cord-005453-4057qib7 6319 34 followed follow VBN cord-005453-4057qib7 6319 35 by by IN cord-005453-4057qib7 6319 36 aGvHD agvhd NN cord-005453-4057qib7 6319 37 ( ( -LRB- cord-005453-4057qib7 6319 38 skin skin NN cord-005453-4057qib7 6319 39 and and CC cord-005453-4057qib7 6319 40 gut gut NN cord-005453-4057qib7 6319 41 involvement involvement NN cord-005453-4057qib7 6319 42 , , , cord-005453-4057qib7 6319 43 grade grade NN cord-005453-4057qib7 6319 44 IV IV NNP cord-005453-4057qib7 6319 45 ) ) -RRB- cord-005453-4057qib7 6319 46 . . . cord-005453-4057qib7 6320 1 Extensive extensive JJ cord-005453-4057qib7 6320 2 immunosuppression immunosuppression NN cord-005453-4057qib7 6320 3 ( ( -LRB- cord-005453-4057qib7 6320 4 steroids steroid NNS cord-005453-4057qib7 6320 5 , , , cord-005453-4057qib7 6320 6 mycofenolate mycofenolate NNP cord-005453-4057qib7 6320 7 mofetile mofetile NNP cord-005453-4057qib7 6320 8 , , , cord-005453-4057qib7 6320 9 ATG ATG NNP cord-005453-4057qib7 6320 10 , , , cord-005453-4057qib7 6320 11 OKT3 OKT3 NNP cord-005453-4057qib7 6320 12 ) ) -RRB- cord-005453-4057qib7 6320 13 resulted result VBD cord-005453-4057qib7 6320 14 in in IN cord-005453-4057qib7 6320 15 significant significant JJ cord-005453-4057qib7 6320 16 resolution resolution NN cord-005453-4057qib7 6320 17 of of IN cord-005453-4057qib7 6320 18 aGvHD agvhd NN cord-005453-4057qib7 6320 19 symptoms symptom NNS cord-005453-4057qib7 6320 20 . . . cord-005453-4057qib7 6321 1 However however RB cord-005453-4057qib7 6321 2 aggravating aggravating JJ cord-005453-4057qib7 6321 3 severe severe JJ cord-005453-4057qib7 6321 4 abdominal abdominal JJ cord-005453-4057qib7 6321 5 pain pain NN cord-005453-4057qib7 6321 6 and and CC cord-005453-4057qib7 6321 7 lack lack NN cord-005453-4057qib7 6321 8 of of IN cord-005453-4057qib7 6321 9 gut gut NN cord-005453-4057qib7 6321 10 movement movement NN cord-005453-4057qib7 6321 11 suggesting suggest VBG cord-005453-4057qib7 6321 12 bowel bowel JJ cord-005453-4057qib7 6321 13 obstruction obstruction NN cord-005453-4057qib7 6321 14 . . . cord-005453-4057qib7 6322 1 Due due IN cord-005453-4057qib7 6322 2 to to IN cord-005453-4057qib7 6322 3 presence presence NN cord-005453-4057qib7 6322 4 of of IN cord-005453-4057qib7 6322 5 acute acute JJ cord-005453-4057qib7 6322 6 abdomen abdomen NN cord-005453-4057qib7 6322 7 patient patient NN cord-005453-4057qib7 6322 8 was be VBD cord-005453-4057qib7 6322 9 immediately immediately RB cord-005453-4057qib7 6322 10 directed direct VBN cord-005453-4057qib7 6322 11 for for IN cord-005453-4057qib7 6322 12 laparotomy laparotomy NN cord-005453-4057qib7 6322 13 . . . cord-005453-4057qib7 6323 1 Resection resection NN cord-005453-4057qib7 6323 2 of of IN cord-005453-4057qib7 6323 3 constricted constricted JJ cord-005453-4057qib7 6323 4 bowel bowel NN cord-005453-4057qib7 6323 5 segment segment NN cord-005453-4057qib7 6323 6 followed follow VBN cord-005453-4057qib7 6323 7 by by IN cord-005453-4057qib7 6323 8 2 2 CD cord-005453-4057qib7 6323 9 subsequent subsequent JJ cord-005453-4057qib7 6323 10 laparotomies laparotomy NNS cord-005453-4057qib7 6323 11 for for IN cord-005453-4057qib7 6323 12 secondary secondary JJ cord-005453-4057qib7 6323 13 obstruction obstruction NN cord-005453-4057qib7 6323 14 provided provide VBD cord-005453-4057qib7 6323 15 complete complete JJ cord-005453-4057qib7 6323 16 resolution resolution NN cord-005453-4057qib7 6323 17 of of IN cord-005453-4057qib7 6323 18 abdominal abdominal JJ cord-005453-4057qib7 6323 19 symptoms symptom NNS cord-005453-4057qib7 6323 20 . . . cord-005453-4057qib7 6324 1 After after IN cord-005453-4057qib7 6324 2 16 16 CD cord-005453-4057qib7 6324 3 years year NNS cord-005453-4057qib7 6324 4 of of IN cord-005453-4057qib7 6324 5 follow follow VB cord-005453-4057qib7 6324 6 - - HYPH cord-005453-4057qib7 6324 7 up up NN cord-005453-4057qib7 6324 8 patient patient NN cord-005453-4057qib7 6324 9 is be VBZ cord-005453-4057qib7 6324 10 alive alive JJ cord-005453-4057qib7 6324 11 and and CC cord-005453-4057qib7 6324 12 well well RB cord-005453-4057qib7 6324 13 . . . cord-005453-4057qib7 6325 1 2 2 LS cord-005453-4057qib7 6325 2 . . . cord-005453-4057qib7 6326 1 Eleven eleven CD cord-005453-4057qib7 6326 2 years year NNS cord-005453-4057qib7 6326 3 old old JJ cord-005453-4057qib7 6326 4 male male NN cord-005453-4057qib7 6326 5 was be VBD cord-005453-4057qib7 6326 6 diagnosed diagnose VBN cord-005453-4057qib7 6326 7 with with IN cord-005453-4057qib7 6326 8 skin skin NN cord-005453-4057qib7 6326 9 and and CC cord-005453-4057qib7 6326 10 gut gut NN cord-005453-4057qib7 6326 11 grade grade NN cord-005453-4057qib7 6326 12 IV IV NNP cord-005453-4057qib7 6326 13 aGvHD agvhd NN cord-005453-4057qib7 6326 14 on on IN cord-005453-4057qib7 6326 15 day day NN cord-005453-4057qib7 6326 16 +84 +84 NNP cord-005453-4057qib7 6327 1 post post NNP cord-005453-4057qib7 6327 2 MUD MUD NNP cord-005453-4057qib7 6327 3 - - HYPH cord-005453-4057qib7 6327 4 HSCT HSCT NNP cord-005453-4057qib7 6327 5 performed perform VBD cord-005453-4057qib7 6327 6 due due IN cord-005453-4057qib7 6327 7 to to IN cord-005453-4057qib7 6327 8 acute acute JJ cord-005453-4057qib7 6327 9 myelogenous myelogenous NN cord-005453-4057qib7 6327 10 leukemia leukemia NN cord-005453-4057qib7 6327 11 ( ( -LRB- cord-005453-4057qib7 6327 12 AML AML NNP cord-005453-4057qib7 6327 13 ) ) -RRB- cord-005453-4057qib7 6327 14 . . . cord-005453-4057qib7 6328 1 He -PRON- PRP cord-005453-4057qib7 6328 2 received receive VBD cord-005453-4057qib7 6328 3 pronlonged pronlonged JJ cord-005453-4057qib7 6328 4 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6328 5 treatment treatment NN cord-005453-4057qib7 6328 6 including include VBG cord-005453-4057qib7 6328 7 steroids steroid NNS cord-005453-4057qib7 6328 8 , , , cord-005453-4057qib7 6328 9 antibodies antibody NNS cord-005453-4057qib7 6328 10 , , , cord-005453-4057qib7 6328 11 MSC MSC NNP cord-005453-4057qib7 6328 12 and and CC cord-005453-4057qib7 6328 13 ECP ECP NNP cord-005453-4057qib7 6328 14 which which WDT cord-005453-4057qib7 6328 15 led lead VBD cord-005453-4057qib7 6328 16 to to IN cord-005453-4057qib7 6328 17 resolving resolve VBG cord-005453-4057qib7 6328 18 of of IN cord-005453-4057qib7 6328 19 skin skin NN cord-005453-4057qib7 6328 20 leasions leasion NNS cord-005453-4057qib7 6328 21 and and CC cord-005453-4057qib7 6328 22 diarhoea diarhoea NN cord-005453-4057qib7 6328 23 . . . cord-005453-4057qib7 6329 1 Nevertheless nevertheless RB cord-005453-4057qib7 6329 2 patient patient JJ cord-005453-4057qib7 6329 3 was be VBD cord-005453-4057qib7 6329 4 suffering suffer VBG cord-005453-4057qib7 6329 5 from from IN cord-005453-4057qib7 6329 6 severe severe JJ cord-005453-4057qib7 6329 7 paroxysmal paroxysmal JJ cord-005453-4057qib7 6329 8 abdominal abdominal JJ cord-005453-4057qib7 6329 9 pain pain NN cord-005453-4057qib7 6329 10 and and CC cord-005453-4057qib7 6329 11 incidentally incidentally RB cord-005453-4057qib7 6329 12 vomiting vomit VBG cord-005453-4057qib7 6329 13 . . . cord-005453-4057qib7 6330 1 CT CT NNP cord-005453-4057qib7 6330 2 enterography enterography NN cord-005453-4057qib7 6330 3 showed show VBD cord-005453-4057qib7 6330 4 partial partial JJ cord-005453-4057qib7 6330 5 small small JJ cord-005453-4057qib7 6330 6 bowel bowel NN cord-005453-4057qib7 6330 7 constriction constriction NN cord-005453-4057qib7 6330 8 . . . cord-005453-4057qib7 6331 1 After after IN cord-005453-4057qib7 6331 2 numerous numerous JJ cord-005453-4057qib7 6331 3 surgical surgical JJ cord-005453-4057qib7 6331 4 consultations consultation NNS cord-005453-4057qib7 6331 5 , , , cord-005453-4057qib7 6331 6 eventually eventually RB cord-005453-4057qib7 6331 7 on on IN cord-005453-4057qib7 6331 8 day+ day+ NNP cord-005453-4057qib7 6331 9 503 503 CD cord-005453-4057qib7 6331 10 patient patient NN cord-005453-4057qib7 6331 11 underwent undergo VBD cord-005453-4057qib7 6331 12 laparotomy laparotomy NN cord-005453-4057qib7 6331 13 with with IN cord-005453-4057qib7 6331 14 constricted constricted JJ cord-005453-4057qib7 6331 15 bowel bowel NN cord-005453-4057qib7 6331 16 resection resection NN cord-005453-4057qib7 6331 17 . . . cord-005453-4057qib7 6332 1 Histopatological histopatological JJ cord-005453-4057qib7 6332 2 examination examination NN cord-005453-4057qib7 6332 3 of of IN cord-005453-4057qib7 6332 4 resected resected JJ cord-005453-4057qib7 6332 5 tissue tissue NN cord-005453-4057qib7 6332 6 revealed reveal VBD cord-005453-4057qib7 6332 7 moderate moderate JJ cord-005453-4057qib7 6332 8 GvHD GvHD NNP cord-005453-4057qib7 6332 9 . . . cord-005453-4057qib7 6333 1 Immunosuppersion Immunosuppersion NNP cord-005453-4057qib7 6333 2 was be VBD cord-005453-4057qib7 6333 3 tapered taper VBN cord-005453-4057qib7 6333 4 to to IN cord-005453-4057qib7 6333 5 low low JJ cord-005453-4057qib7 6333 6 dose dose NN cord-005453-4057qib7 6333 7 of of IN cord-005453-4057qib7 6333 8 steroids steroid NNS cord-005453-4057qib7 6333 9 with with IN cord-005453-4057qib7 6333 10 ECP ECP NNP cord-005453-4057qib7 6333 11 . . . cord-005453-4057qib7 6334 1 For for IN cord-005453-4057qib7 6334 2 now now RB cord-005453-4057qib7 6334 3 , , , cord-005453-4057qib7 6334 4 2 2 CD cord-005453-4057qib7 6334 5 years year NNS cord-005453-4057qib7 6334 6 post post NN cord-005453-4057qib7 6334 7 HSCT HSCT NNP cord-005453-4057qib7 6334 8 patient patient NN cord-005453-4057qib7 6334 9 is be VBZ cord-005453-4057qib7 6334 10 alive alive JJ cord-005453-4057qib7 6334 11 , , , cord-005453-4057qib7 6334 12 rarely rarely RB cord-005453-4057qib7 6334 13 experiencing experience VBG cord-005453-4057qib7 6334 14 mild mild JJ cord-005453-4057qib7 6334 15 abdominal abdominal JJ cord-005453-4057qib7 6334 16 cramps cramp NNS cord-005453-4057qib7 6334 17 3 3 CD cord-005453-4057qib7 6334 18 . . . cord-005453-4057qib7 6335 1 Fourteen fourteen CD cord-005453-4057qib7 6335 2 years year NNS cord-005453-4057qib7 6335 3 old old JJ cord-005453-4057qib7 6335 4 female female NN cord-005453-4057qib7 6335 5 developed develop VBD cord-005453-4057qib7 6335 6 severe severe JJ cord-005453-4057qib7 6335 7 abdominal abdominal JJ cord-005453-4057qib7 6335 8 pain pain NN cord-005453-4057qib7 6335 9 and and CC cord-005453-4057qib7 6335 10 high high JJ cord-005453-4057qib7 6335 11 volume volume NN cord-005453-4057qib7 6335 12 diarhoea diarhoea NN cord-005453-4057qib7 6335 13 on on IN cord-005453-4057qib7 6335 14 day day NN cord-005453-4057qib7 6335 15 +24 +24 CD cord-005453-4057qib7 6335 16 post post NNP cord-005453-4057qib7 6335 17 MUD MUD NNP cord-005453-4057qib7 6335 18 - - HYPH cord-005453-4057qib7 6335 19 HSCT HSCT NNP cord-005453-4057qib7 6336 1 performed perform VBN cord-005453-4057qib7 6336 2 for for IN cord-005453-4057qib7 6336 3 severe severe JJ cord-005453-4057qib7 6336 4 anaplastic anaplastic JJ cord-005453-4057qib7 6336 5 anemia anemia NN cord-005453-4057qib7 6336 6 ( ( -LRB- cord-005453-4057qib7 6336 7 SAA SAA NNP cord-005453-4057qib7 6336 8 ) ) -RRB- cord-005453-4057qib7 6336 9 . . . cord-005453-4057qib7 6337 1 Despite despite IN cord-005453-4057qib7 6337 2 extensive extensive JJ cord-005453-4057qib7 6337 3 immunosuppression immunosuppression NN cord-005453-4057qib7 6337 4 ( ( -LRB- cord-005453-4057qib7 6337 5 steroids steroid NNS cord-005453-4057qib7 6337 6 , , , cord-005453-4057qib7 6337 7 anti anti NNP cord-005453-4057qib7 6337 8 - - NNP cord-005453-4057qib7 6337 9 TNF TNF NNP cord-005453-4057qib7 6337 10 , , , cord-005453-4057qib7 6337 11 anti anti JJ cord-005453-4057qib7 6337 12 - - JJ cord-005453-4057qib7 6337 13 IL2 il2 JJ cord-005453-4057qib7 6337 14 antibodies antibody NNS cord-005453-4057qib7 6337 15 ) ) -RRB- cord-005453-4057qib7 6338 1 patient patient JJ cord-005453-4057qib7 6338 2 condition condition NN cord-005453-4057qib7 6338 3 did do VBD cord-005453-4057qib7 6338 4 not not RB cord-005453-4057qib7 6338 5 improved improve VBN cord-005453-4057qib7 6338 6 . . . cord-005453-4057qib7 6339 1 Through through IN cord-005453-4057qib7 6339 2 consistent consistent JJ cord-005453-4057qib7 6339 3 stomach stomach NN cord-005453-4057qib7 6339 4 pain pain NN cord-005453-4057qib7 6339 5 , , , cord-005453-4057qib7 6339 6 suspected suspect VBN cord-005453-4057qib7 6339 7 subileus subileu NNS cord-005453-4057qib7 6339 8 confirmed confirm VBN cord-005453-4057qib7 6339 9 by by IN cord-005453-4057qib7 6339 10 CT CT NNP cord-005453-4057qib7 6339 11 enterography enterography NN cord-005453-4057qib7 6339 12 , , , cord-005453-4057qib7 6339 13 laparotomy laparotomy NN cord-005453-4057qib7 6339 14 was be VBD cord-005453-4057qib7 6339 15 performed perform VBN cord-005453-4057qib7 6339 16 ( ( -LRB- cord-005453-4057qib7 6339 17 day+158 day+158 NNP cord-005453-4057qib7 6339 18 ) ) -RRB- cord-005453-4057qib7 6339 19 . . . cord-005453-4057qib7 6340 1 Resection resection NN cord-005453-4057qib7 6340 2 of of IN cord-005453-4057qib7 6340 3 inflamated inflamated JJ cord-005453-4057qib7 6340 4 and and CC cord-005453-4057qib7 6340 5 obstructed obstructed JJ cord-005453-4057qib7 6340 6 bowel bowel NN cord-005453-4057qib7 6340 7 was be VBD cord-005453-4057qib7 6340 8 made make VBN cord-005453-4057qib7 6340 9 . . . cord-005453-4057qib7 6341 1 Microscopic microscopic JJ cord-005453-4057qib7 6341 2 evaluation evaluation NN cord-005453-4057qib7 6341 3 confirmed confirm VBD cord-005453-4057qib7 6341 4 prior prior JJ cord-005453-4057qib7 6341 5 GvHD GvHD NNP cord-005453-4057qib7 6341 6 diagnosis diagnosis NN cord-005453-4057qib7 6341 7 therefore therefore RB cord-005453-4057qib7 6341 8 immunosuppression immunosuppression NN cord-005453-4057qib7 6341 9 including include VBG cord-005453-4057qib7 6341 10 CsA csa NN cord-005453-4057qib7 6341 11 and and CC cord-005453-4057qib7 6341 12 tapered tapered JJ cord-005453-4057qib7 6341 13 doses dose NNS cord-005453-4057qib7 6341 14 of of IN cord-005453-4057qib7 6341 15 steroids steroid NNS cord-005453-4057qib7 6341 16 was be VBD cord-005453-4057qib7 6341 17 continued continue VBN cord-005453-4057qib7 6341 18 . . . cord-005453-4057qib7 6342 1 Complete complete JJ cord-005453-4057qib7 6342 2 resolution resolution NN cord-005453-4057qib7 6342 3 of of IN cord-005453-4057qib7 6342 4 abdominal abdominal JJ cord-005453-4057qib7 6342 5 symptoms symptom NNS cord-005453-4057qib7 6342 6 was be VBD cord-005453-4057qib7 6342 7 almost almost RB cord-005453-4057qib7 6342 8 immediately immediately RB cord-005453-4057qib7 6342 9 achieved achieve VBN cord-005453-4057qib7 6342 10 post post NN cord-005453-4057qib7 6342 11 - - NN cord-005453-4057qib7 6342 12 surgery surgery JJ cord-005453-4057qib7 6342 13 , , , cord-005453-4057qib7 6342 14 however however RB cord-005453-4057qib7 6342 15 2 2 CD cord-005453-4057qib7 6342 16 months month NNS cord-005453-4057qib7 6342 17 after after IN cord-005453-4057qib7 6342 18 recurrent recurrent JJ cord-005453-4057qib7 6342 19 abdominal abdominal JJ cord-005453-4057qib7 6342 20 cramps cramp NNS cord-005453-4057qib7 6342 21 were be VBD cord-005453-4057qib7 6342 22 observed observe VBN cord-005453-4057qib7 6342 23 and and CC cord-005453-4057qib7 6342 24 are be VBP cord-005453-4057qib7 6342 25 now now RB cord-005453-4057qib7 6342 26 well well RB cord-005453-4057qib7 6342 27 controlled control VBN cord-005453-4057qib7 6342 28 by by IN cord-005453-4057qib7 6342 29 pain pain NN cord-005453-4057qib7 6342 30 killers killer NNS cord-005453-4057qib7 6342 31 . . . cord-005453-4057qib7 6343 1 Conclusions conclusion NNS cord-005453-4057qib7 6343 2 : : : cord-005453-4057qib7 6344 1 Commonly commonly RB cord-005453-4057qib7 6344 2 GI GI NNP cord-005453-4057qib7 6344 3 GvHD GvHD NNP cord-005453-4057qib7 6344 4 is be VBZ cord-005453-4057qib7 6344 5 diffused diffuse VBN cord-005453-4057qib7 6344 6 inflammatory inflammatory JJ cord-005453-4057qib7 6344 7 process process NN cord-005453-4057qib7 6344 8 . . . cord-005453-4057qib7 6345 1 However however RB cord-005453-4057qib7 6345 2 in in IN cord-005453-4057qib7 6345 3 some some DT cord-005453-4057qib7 6345 4 cases case NNS cord-005453-4057qib7 6345 5 it -PRON- PRP cord-005453-4057qib7 6345 6 may may MD cord-005453-4057qib7 6345 7 be be VB cord-005453-4057qib7 6345 8 localized localize VBN cord-005453-4057qib7 6345 9 and and CC cord-005453-4057qib7 6345 10 may may MD cord-005453-4057qib7 6345 11 lead lead VB cord-005453-4057qib7 6345 12 to to IN cord-005453-4057qib7 6345 13 partial partial JJ cord-005453-4057qib7 6345 14 bowel bowel NN cord-005453-4057qib7 6345 15 constriction constriction NN cord-005453-4057qib7 6345 16 . . . cord-005453-4057qib7 6346 1 In in IN cord-005453-4057qib7 6346 2 case case NN cord-005453-4057qib7 6346 3 of of IN cord-005453-4057qib7 6346 4 severe severe JJ cord-005453-4057qib7 6346 5 and and CC cord-005453-4057qib7 6346 6 prolonged prolonged JJ cord-005453-4057qib7 6346 7 stomach stomach NN cord-005453-4057qib7 6346 8 pain pain NN cord-005453-4057qib7 6346 9 , , , cord-005453-4057qib7 6346 10 despite despite IN cord-005453-4057qib7 6346 11 of of IN cord-005453-4057qib7 6346 12 partial partial JJ cord-005453-4057qib7 6346 13 resolving resolving NN cord-005453-4057qib7 6346 14 of of IN cord-005453-4057qib7 6346 15 other other JJ cord-005453-4057qib7 6346 16 GvHD gvhd NN cord-005453-4057qib7 6346 17 symptoms symptom NNS cord-005453-4057qib7 6346 18 , , , cord-005453-4057qib7 6346 19 ileus ileus NNP cord-005453-4057qib7 6346 20 should should MD cord-005453-4057qib7 6346 21 be be VB cord-005453-4057qib7 6346 22 considered consider VBN cord-005453-4057qib7 6346 23 . . . cord-005453-4057qib7 6347 1 CT CT NNP cord-005453-4057qib7 6347 2 enterography enterography NN cord-005453-4057qib7 6347 3 may may MD cord-005453-4057qib7 6347 4 be be VB cord-005453-4057qib7 6347 5 useful useful JJ cord-005453-4057qib7 6347 6 for for IN cord-005453-4057qib7 6347 7 diagnosis diagnosis NN cord-005453-4057qib7 6347 8 confirmation confirmation NN cord-005453-4057qib7 6347 9 . . . cord-005453-4057qib7 6348 1 In in IN cord-005453-4057qib7 6348 2 those those DT cord-005453-4057qib7 6348 3 patients patient NNS cord-005453-4057qib7 6348 4 , , , cord-005453-4057qib7 6348 5 surgical surgical JJ cord-005453-4057qib7 6348 6 intervention intervention NN cord-005453-4057qib7 6348 7 may may MD cord-005453-4057qib7 6348 8 improve improve VB cord-005453-4057qib7 6348 9 quality quality NN cord-005453-4057qib7 6348 10 of of IN cord-005453-4057qib7 6348 11 life life NN cord-005453-4057qib7 6348 12 or or CC cord-005453-4057qib7 6348 13 even even RB cord-005453-4057qib7 6348 14 be be VB cord-005453-4057qib7 6348 15 a a DT cord-005453-4057qib7 6348 16 salvage salvage NN cord-005453-4057qib7 6348 17 approach approach NN cord-005453-4057qib7 6348 18 . . . cord-005453-4057qib7 6349 1 Disclosure disclosure NN cord-005453-4057qib7 6349 2 : : : cord-005453-4057qib7 6349 3 Nothing nothing NN cord-005453-4057qib7 6349 4 to to TO cord-005453-4057qib7 6349 5 disclose disclose VB cord-005453-4057qib7 6349 6 Is be VBZ cord-005453-4057qib7 6349 7 there there EX cord-005453-4057qib7 6349 8 any any DT cord-005453-4057qib7 6349 9 impact impact NN cord-005453-4057qib7 6349 10 of of IN cord-005453-4057qib7 6349 11 the the DT cord-005453-4057qib7 6349 12 uric uric JJ cord-005453-4057qib7 6349 13 acid acid NN cord-005453-4057qib7 6349 14 levels level NNS cord-005453-4057qib7 6349 15 during during IN cord-005453-4057qib7 6349 16 the the DT cord-005453-4057qib7 6349 17 preand preand NN cord-005453-4057qib7 6349 18 early early JJ cord-005453-4057qib7 6349 19 post post JJ cord-005453-4057qib7 6349 20 - - JJ cord-005453-4057qib7 6349 21 graft graft NN cord-005453-4057qib7 6349 22 infusion infusion NN cord-005453-4057qib7 6349 23 period period NN cord-005453-4057qib7 6349 24 , , , cord-005453-4057qib7 6349 25 on on IN cord-005453-4057qib7 6349 26 the the DT cord-005453-4057qib7 6349 27 GVHD GVHD NNP cord-005453-4057qib7 6349 28 occurence occurence NN cord-005453-4057qib7 6349 29 and and CC cord-005453-4057qib7 6349 30 allotransplant allotransplant JJ cord-005453-4057qib7 6349 31 outcome outcome NN cord-005453-4057qib7 6349 32 ? ? . cord-005453-4057qib7 6350 1 36.8(16.7 36.8(16.7 CD cord-005453-4057qib7 6350 2 - - SYM cord-005453-4057qib7 6350 3 61.6 61.6 CD cord-005453-4057qib7 6350 4 ) ) -RRB- cord-005453-4057qib7 6350 5 years year NNS cord-005453-4057qib7 6350 6 , , , cord-005453-4057qib7 6350 7 who who WP cord-005453-4057qib7 6350 8 underwent undergo VBD cord-005453-4057qib7 6350 9 allogeneic allogeneic JJ cord-005453-4057qib7 6350 10 stem stem NN cord-005453-4057qib7 6350 11 cell cell NN cord-005453-4057qib7 6350 12 transplantation transplantation NN cord-005453-4057qib7 6350 13 ( ( -LRB- cord-005453-4057qib7 6350 14 alloSCT alloSCT NNP cord-005453-4057qib7 6350 15 ) ) -RRB- cord-005453-4057qib7 6350 16 from from IN cord-005453-4057qib7 6350 17 full full RB cord-005453-4057qib7 6350 18 - - HYPH cord-005453-4057qib7 6350 19 matched match VBN cord-005453-4057qib7 6350 20 sibling sibling NN cord-005453-4057qib7 6350 21 donors donor NNS cord-005453-4057qib7 6350 22 for for IN cord-005453-4057qib7 6350 23 acute acute JJ cord-005453-4057qib7 6350 24 leukemia leukemia NN cord-005453-4057qib7 6350 25 ( ( -LRB- cord-005453-4057qib7 6350 26 n=31 n=31 NNP cord-005453-4057qib7 6350 27 ) ) -RRB- cord-005453-4057qib7 6350 28 , , , cord-005453-4057qib7 6350 29 very very RB cord-005453-4057qib7 6350 30 severe severe JJ cord-005453-4057qib7 6350 31 aplastic aplastic JJ cord-005453-4057qib7 6350 32 anemia anemia NN cord-005453-4057qib7 6350 33 / / , cord-005453-4057qib7 6350 34 PNH PNH NNP cord-005453-4057qib7 6350 35 ( ( -LRB- cord-005453-4057qib7 6350 36 n=5 n=5 NNP cord-005453-4057qib7 6350 37 ) ) -RRB- cord-005453-4057qib7 6350 38 , , , cord-005453-4057qib7 6350 39 lymphoma lymphoma NN cord-005453-4057qib7 6350 40 ( ( -LRB- cord-005453-4057qib7 6350 41 n=3 n=3 NN cord-005453-4057qib7 6350 42 ) ) -RRB- cord-005453-4057qib7 6350 43 , , , cord-005453-4057qib7 6350 44 myelodysplastic/ myelodysplastic/ JJ cord-005453-4057qib7 6350 45 myeloproliferative myeloproliferative NNP cord-005453-4057qib7 6350 46 syndrome syndrome NN cord-005453-4057qib7 6350 47 ( ( -LRB- cord-005453-4057qib7 6350 48 n=3 n=3 NN cord-005453-4057qib7 6350 49 ) ) -RRB- cord-005453-4057qib7 6350 50 . . . cord-005453-4057qib7 6351 1 Thirty thirty CD cord-005453-4057qib7 6351 2 - - HYPH cord-005453-4057qib7 6351 3 two two CD cord-005453-4057qib7 6351 4 patients patient NNS cord-005453-4057qib7 6351 5 were be VBD cord-005453-4057qib7 6351 6 in in IN cord-005453-4057qib7 6351 7 remission remission NN cord-005453-4057qib7 6351 8 at at IN cord-005453-4057qib7 6351 9 the the DT cord-005453-4057qib7 6351 10 time time NN cord-005453-4057qib7 6351 11 of of IN cord-005453-4057qib7 6351 12 alloSCT alloSCT NNP cord-005453-4057qib7 6352 1 ( ( -LRB- cord-005453-4057qib7 6352 2 CR1 CR1 NNP cord-005453-4057qib7 6352 3 : : : cord-005453-4057qib7 6352 4 23 23 CD cord-005453-4057qib7 6352 5 , , , cord-005453-4057qib7 6352 6 CR2 CR2 NNP cord-005453-4057qib7 6352 7 : : : cord-005453-4057qib7 6352 8 7 7 CD cord-005453-4057qib7 6352 9 , , , cord-005453-4057qib7 6352 10 beyond beyond IN cord-005453-4057qib7 6352 11 CR2 CR2 NNP cord-005453-4057qib7 6352 12 : : : cord-005453-4057qib7 6352 13 2 2 CD cord-005453-4057qib7 6352 14 ) ) -RRB- cord-005453-4057qib7 6352 15 . . . cord-005453-4057qib7 6353 1 For for IN cord-005453-4057qib7 6353 2 a a DT cord-005453-4057qib7 6353 3 better well JJR cord-005453-4057qib7 6353 4 and and CC cord-005453-4057qib7 6353 5 more more RBR cord-005453-4057qib7 6353 6 accurate accurate JJ cord-005453-4057qib7 6353 7 assessment assessment NN cord-005453-4057qib7 6353 8 of of IN cord-005453-4057qib7 6353 9 the the DT cord-005453-4057qib7 6353 10 UA UA NNP cord-005453-4057qib7 6353 11 levels level NNS cord-005453-4057qib7 6353 12 on on IN cord-005453-4057qib7 6353 13 the the DT cord-005453-4057qib7 6353 14 aGvHD agvhd NN cord-005453-4057qib7 6353 15 incidence incidence NN cord-005453-4057qib7 6353 16 , , , cord-005453-4057qib7 6353 17 unlike unlike IN cord-005453-4057qib7 6353 18 to to IN cord-005453-4057qib7 6353 19 the the DT cord-005453-4057qib7 6353 20 other other JJ cord-005453-4057qib7 6353 21 published publish VBN cord-005453-4057qib7 6353 22 studies study NNS cord-005453-4057qib7 6353 23 which which WDT cord-005453-4057qib7 6353 24 evaluated evaluate VBD cord-005453-4057qib7 6353 25 the the DT cord-005453-4057qib7 6353 26 UA UA NNP cord-005453-4057qib7 6353 27 levels level NNS cord-005453-4057qib7 6353 28 only only RB cord-005453-4057qib7 6353 29 at at IN cord-005453-4057qib7 6353 30 day day NN cord-005453-4057qib7 6353 31 0 0 NFP cord-005453-4057qib7 6353 32 , , , cord-005453-4057qib7 6353 33 we -PRON- PRP cord-005453-4057qib7 6353 34 evaluated evaluate VBD cord-005453-4057qib7 6353 35 the the DT cord-005453-4057qib7 6353 36 UA UA NNP cord-005453-4057qib7 6353 37 levels level NNS cord-005453-4057qib7 6353 38 in in IN cord-005453-4057qib7 6353 39 different different JJ cord-005453-4057qib7 6353 40 time time NN cord-005453-4057qib7 6353 41 points point NNS cord-005453-4057qib7 6353 42 during during IN cord-005453-4057qib7 6353 43 the the DT cord-005453-4057qib7 6353 44 the the DT cord-005453-4057qib7 6353 45 peri peri NN cord-005453-4057qib7 6353 46 - - HYPH cord-005453-4057qib7 6353 47 transplant transplant NN cord-005453-4057qib7 6353 48 period period NN cord-005453-4057qib7 6353 49 ( ( -LRB- cord-005453-4057qib7 6353 50 at at IN cord-005453-4057qib7 6353 51 the the DT cord-005453-4057qib7 6353 52 conditioning conditioning NN cord-005453-4057qib7 6353 53 regimen regimen NN cord-005453-4057qib7 6353 54 initiation initiation NN cord-005453-4057qib7 6353 55 , , , cord-005453-4057qib7 6353 56 and and CC cord-005453-4057qib7 6353 57 at at IN cord-005453-4057qib7 6353 58 days day NNS cord-005453-4057qib7 6353 59 0 0 CD cord-005453-4057qib7 6353 60 , , , cord-005453-4057qib7 6353 61 +7 +7 NN cord-005453-4057qib7 6353 62 and and CC cord-005453-4057qib7 6353 63 +14 +14 CD cord-005453-4057qib7 6353 64 ) ) -RRB- cord-005453-4057qib7 6353 65 . . . cord-005453-4057qib7 6354 1 Because because IN cord-005453-4057qib7 6354 2 the the DT cord-005453-4057qib7 6354 3 majority majority NN cord-005453-4057qib7 6354 4 of of IN cord-005453-4057qib7 6354 5 our -PRON- PRP$ cord-005453-4057qib7 6354 6 patients patient NNS cord-005453-4057qib7 6354 7 developed develop VBN cord-005453-4057qib7 6354 8 aGvHD agvhd NN cord-005453-4057qib7 6354 9 within within IN cord-005453-4057qib7 6354 10 the the DT cord-005453-4057qib7 6354 11 15 15 CD cord-005453-4057qib7 6354 12 - - SYM cord-005453-4057qib7 6354 13 30 30 CD cord-005453-4057qib7 6354 14 days day NNS cord-005453-4057qib7 6354 15 post post NN cord-005453-4057qib7 6354 16 - - NN cord-005453-4057qib7 6354 17 transplant transplant NN cord-005453-4057qib7 6354 18 , , , cord-005453-4057qib7 6354 19 we -PRON- PRP cord-005453-4057qib7 6354 20 did do VBD cord-005453-4057qib7 6354 21 not not RB cord-005453-4057qib7 6354 22 incorporated incorporate VBN cord-005453-4057qib7 6354 23 in in IN cord-005453-4057qib7 6354 24 the the DT cord-005453-4057qib7 6354 25 study study NN cord-005453-4057qib7 6354 26 the the DT cord-005453-4057qib7 6354 27 of of IN cord-005453-4057qib7 6354 28 UA UA NNP cord-005453-4057qib7 6354 29 levels level NNS cord-005453-4057qib7 6354 30 beyond beyond IN cord-005453-4057qib7 6354 31 the the DT cord-005453-4057qib7 6354 32 +14 +14 CD cord-005453-4057qib7 6354 33 day day NN cord-005453-4057qib7 6354 34 . . . cord-005453-4057qib7 6355 1 We -PRON- PRP cord-005453-4057qib7 6355 2 also also RB cord-005453-4057qib7 6355 3 investigated investigate VBD cord-005453-4057qib7 6355 4 the the DT cord-005453-4057qib7 6355 5 effect effect NN cord-005453-4057qib7 6355 6 of of IN cord-005453-4057qib7 6355 7 the the DT cord-005453-4057qib7 6355 8 UA UA NNP cord-005453-4057qib7 6355 9 on on IN cord-005453-4057qib7 6355 10 survival survival NN cord-005453-4057qib7 6355 11 and and CC cord-005453-4057qib7 6355 12 the the DT cord-005453-4057qib7 6355 13 non non JJ cord-005453-4057qib7 6355 14 - - JJ cord-005453-4057qib7 6355 15 relapse relapse JJ cord-005453-4057qib7 6355 16 mortality mortality NN cord-005453-4057qib7 6355 17 ( ( -LRB- cord-005453-4057qib7 6355 18 NRM NRM NNP cord-005453-4057qib7 6355 19 ) ) -RRB- cord-005453-4057qib7 6355 20 . . . cord-005453-4057qib7 6356 1 The the DT cord-005453-4057qib7 6356 2 vast vast JJ cord-005453-4057qib7 6356 3 majority majority NN cord-005453-4057qib7 6356 4 of of IN cord-005453-4057qib7 6356 5 patients patient NNS cord-005453-4057qib7 6356 6 received receive VBD cord-005453-4057qib7 6356 7 allopurinol allopurinol NN cord-005453-4057qib7 6356 8 from from IN cord-005453-4057qib7 6356 9 the the DT cord-005453-4057qib7 6356 10 1 1 CD cord-005453-4057qib7 6356 11 st st NNP cord-005453-4057qib7 6356 12 day day NN cord-005453-4057qib7 6356 13 of of IN cord-005453-4057qib7 6356 14 conditioning conditioning NN cord-005453-4057qib7 6356 15 regimen regimen NN cord-005453-4057qib7 6356 16 till till IN cord-005453-4057qib7 6356 17 day day NN cord-005453-4057qib7 6356 18 -1 -1 CD cord-005453-4057qib7 6356 19 . . . cord-005453-4057qib7 6357 1 The the DT cord-005453-4057qib7 6357 2 independent independent JJ cord-005453-4057qib7 6357 3 T t NN cord-005453-4057qib7 6357 4 - - HYPH cord-005453-4057qib7 6357 5 test test NN cord-005453-4057qib7 6357 6 , , , cord-005453-4057qib7 6357 7 Kaplan Kaplan NNP cord-005453-4057qib7 6357 8 - - HYPH cord-005453-4057qib7 6357 9 Meir Meir NNP cord-005453-4057qib7 6357 10 method method NN cord-005453-4057qib7 6357 11 and and CC cord-005453-4057qib7 6357 12 logrank logrank NN cord-005453-4057qib7 6357 13 test test NN cord-005453-4057qib7 6357 14 were be VBD cord-005453-4057qib7 6357 15 used use VBN cord-005453-4057qib7 6357 16 in in IN cord-005453-4057qib7 6357 17 the the DT cord-005453-4057qib7 6357 18 statistical statistical JJ cord-005453-4057qib7 6357 19 analysis analysis NN cord-005453-4057qib7 6357 20 . . . cord-005453-4057qib7 6358 1 Results result NNS cord-005453-4057qib7 6358 2 : : : cord-005453-4057qib7 6359 1 The the DT cord-005453-4057qib7 6359 2 median median JJ cord-005453-4057qib7 6359 3 UA UA NNP cord-005453-4057qib7 6359 4 levels level NNS cord-005453-4057qib7 6359 5 were be VBD cord-005453-4057qib7 6359 6 4.2 4.2 CD cord-005453-4057qib7 6359 7 , , , cord-005453-4057qib7 6359 8 2.5 2.5 CD cord-005453-4057qib7 6359 9 , , , cord-005453-4057qib7 6359 10 2.7 2.7 CD cord-005453-4057qib7 6359 11 and and CC cord-005453-4057qib7 6359 12 3.2 3.2 CD cord-005453-4057qib7 6359 13 mg mg NNP cord-005453-4057qib7 6359 14 / / SYM cord-005453-4057qib7 6359 15 dl dl NN cord-005453-4057qib7 6359 16 at at IN cord-005453-4057qib7 6359 17 days day NNS cord-005453-4057qib7 6359 18 -7 -7 NNP cord-005453-4057qib7 6359 19 , , , cord-005453-4057qib7 6359 20 0 0 CD cord-005453-4057qib7 6359 21 , , , cord-005453-4057qib7 6359 22 +7 +7 NN cord-005453-4057qib7 6359 23 and and CC cord-005453-4057qib7 6359 24 +14 +14 CD cord-005453-4057qib7 6359 25 respectively respectively RB cord-005453-4057qib7 6359 26 . . . cord-005453-4057qib7 6360 1 For for IN cord-005453-4057qib7 6360 2 the the DT cord-005453-4057qib7 6360 3 statistical statistical JJ cord-005453-4057qib7 6360 4 analysis analysis NN cord-005453-4057qib7 6360 5 purposes purpose NNS cord-005453-4057qib7 6360 6 , , , cord-005453-4057qib7 6360 7 we -PRON- PRP cord-005453-4057qib7 6360 8 grouped group VBD cord-005453-4057qib7 6360 9 our -PRON- PRP$ cord-005453-4057qib7 6360 10 patients patient NNS cord-005453-4057qib7 6360 11 as as IN cord-005453-4057qib7 6360 12 low low JJ cord-005453-4057qib7 6360 13 - - HYPH cord-005453-4057qib7 6360 14 UA ua NN cord-005453-4057qib7 6360 15 if if IN cord-005453-4057qib7 6360 16 they -PRON- PRP cord-005453-4057qib7 6360 17 had have VBD cord-005453-4057qib7 6360 18 values value NNS cord-005453-4057qib7 6360 19 < < XX cord-005453-4057qib7 6360 20 3 3 CD cord-005453-4057qib7 6360 21 mg mg NNP cord-005453-4057qib7 6360 22 / / SYM cord-005453-4057qib7 6360 23 dl dl NN cord-005453-4057qib7 6360 24 or or CC cord-005453-4057qib7 6360 25 high high JJ cord-005453-4057qib7 6360 26 - - HYPH cord-005453-4057qib7 6360 27 UA ua NN cord-005453-4057qib7 6360 28 if if IN cord-005453-4057qib7 6360 29 they -PRON- PRP cord-005453-4057qib7 6360 30 had have VBD cord-005453-4057qib7 6360 31 > > XX cord-005453-4057qib7 6361 1 3 3 CD cord-005453-4057qib7 6361 2 mg mg NNP cord-005453-4057qib7 6361 3 / / SYM cord-005453-4057qib7 6361 4 dl dl NN cord-005453-4057qib7 6361 5 . . . cord-005453-4057qib7 6362 1 This this DT cord-005453-4057qib7 6362 2 threshold threshold NN cord-005453-4057qib7 6362 3 was be VBD cord-005453-4057qib7 6362 4 chosen choose VBN cord-005453-4057qib7 6362 5 based base VBN cord-005453-4057qib7 6362 6 on on IN cord-005453-4057qib7 6362 7 the the DT cord-005453-4057qib7 6362 8 UA UA NNP cord-005453-4057qib7 6362 9 values value NNS cord-005453-4057qib7 6362 10 from from IN cord-005453-4057qib7 6362 11 all all PDT cord-005453-4057qib7 6362 12 the the DT cord-005453-4057qib7 6362 13 collected collect VBN cord-005453-4057qib7 6362 14 samples sample NNS cord-005453-4057qib7 6362 15 ( ( -LRB- cord-005453-4057qib7 6362 16 n=175 n=175 RB cord-005453-4057qib7 6362 17 ) ) -RRB- cord-005453-4057qib7 6362 18 . . . cord-005453-4057qib7 6363 1 Finally finally RB cord-005453-4057qib7 6363 2 16/ 16/ CD cord-005453-4057qib7 6363 3 42 42 CD cord-005453-4057qib7 6363 4 ( ( -LRB- cord-005453-4057qib7 6363 5 38 38 CD cord-005453-4057qib7 6363 6 % % NN cord-005453-4057qib7 6363 7 ) ) -RRB- cord-005453-4057qib7 6364 1 patients patient NNS cord-005453-4057qib7 6364 2 developed develop VBD cord-005453-4057qib7 6364 3 aGvHD agvhd NN cord-005453-4057qib7 6364 4 ; ; : cord-005453-4057qib7 6364 5 14(33 14(33 CD cord-005453-4057qib7 6364 6 % % NN cord-005453-4057qib7 6364 7 ) ) -RRB- cord-005453-4057qib7 6364 8 were be VBD cord-005453-4057qib7 6364 9 assessed assess VBN cord-005453-4057qib7 6364 10 as as IN cord-005453-4057qib7 6364 11 gr gr NNP cord-005453-4057qib7 6365 1 ≥II ≥ii UH cord-005453-4057qib7 6365 2 , , , cord-005453-4057qib7 6365 3 while while IN cord-005453-4057qib7 6365 4 7(16 7(16 CD cord-005453-4057qib7 6365 5 % % NN cord-005453-4057qib7 6365 6 ) ) -RRB- cord-005453-4057qib7 6365 7 as as IN cord-005453-4057qib7 6365 8 gr gr NNP cord-005453-4057qib7 6365 9 III III NNP cord-005453-4057qib7 6365 10 - - HYPH cord-005453-4057qib7 6365 11 IV IV NNP cord-005453-4057qib7 6365 12 . . . cord-005453-4057qib7 6366 1 The the DT cord-005453-4057qib7 6366 2 incidence incidence NN cord-005453-4057qib7 6366 3 of of IN cord-005453-4057qib7 6366 4 the the DT cord-005453-4057qib7 6366 5 aGvHD agvhd NN cord-005453-4057qib7 6366 6 gr gr NNP cord-005453-4057qib7 6366 7 ≥II ≥II NNP cord-005453-4057qib7 6366 8 was be VBD cord-005453-4057qib7 6366 9 similar similar JJ cord-005453-4057qib7 6366 10 ( ( -LRB- cord-005453-4057qib7 6366 11 ranged range VBN cord-005453-4057qib7 6366 12 from from IN cord-005453-4057qib7 6366 13 30 30 CD cord-005453-4057qib7 6366 14 - - SYM cord-005453-4057qib7 6366 15 35 35 CD cord-005453-4057qib7 6366 16 % % NN cord-005453-4057qib7 6366 17 ) ) -RRB- cord-005453-4057qib7 6366 18 in in IN cord-005453-4057qib7 6366 19 both both DT cord-005453-4057qib7 6366 20 groups group NNS cord-005453-4057qib7 6366 21 of of IN cord-005453-4057qib7 6366 22 patients patient NNS cord-005453-4057qib7 6366 23 ( ( -LRB- cord-005453-4057qib7 6366 24 low low JJ cord-005453-4057qib7 6366 25 - - HYPH cord-005453-4057qib7 6366 26 UA ua NN cord-005453-4057qib7 6366 27 and and CC cord-005453-4057qib7 6366 28 high high JJ cord-005453-4057qib7 6366 29 - - HYPH cord-005453-4057qib7 6366 30 UA ua NN cord-005453-4057qib7 6366 31 ) ) -RRB- cord-005453-4057qib7 6366 32 and and CC cord-005453-4057qib7 6366 33 for for IN cord-005453-4057qib7 6366 34 all all PDT cord-005453-4057qib7 6366 35 the the DT cord-005453-4057qib7 6366 36 estimated estimate VBN cord-005453-4057qib7 6366 37 time time NN cord-005453-4057qib7 6366 38 points point NNS cord-005453-4057qib7 6366 39 ( ( -LRB- cord-005453-4057qib7 6366 40 days day NNS cord-005453-4057qib7 6366 41 -7 -7 NNP cord-005453-4057qib7 6366 42 , , , cord-005453-4057qib7 6366 43 0 0 CD cord-005453-4057qib7 6366 44 , , , cord-005453-4057qib7 6366 45 +7 +7 NN cord-005453-4057qib7 6366 46 , , , cord-005453-4057qib7 6366 47 +14 +14 CD cord-005453-4057qib7 6366 48 ) ) -RRB- cord-005453-4057qib7 6366 49 . . . cord-005453-4057qib7 6367 1 We -PRON- PRP cord-005453-4057qib7 6367 2 noticed notice VBD cord-005453-4057qib7 6367 3 a a DT cord-005453-4057qib7 6367 4 better well JJR cord-005453-4057qib7 6367 5 2-years 2-years CD cord-005453-4057qib7 6367 6 overall overall JJ cord-005453-4057qib7 6367 7 survival survival NN cord-005453-4057qib7 6367 8 for for IN cord-005453-4057qib7 6367 9 patients patient NNS cord-005453-4057qib7 6367 10 with with IN cord-005453-4057qib7 6367 11 low low JJ cord-005453-4057qib7 6367 12 - - HYPH cord-005453-4057qib7 6367 13 UA ua NN cord-005453-4057qib7 6367 14 ( ( -LRB- cord-005453-4057qib7 6367 15 75 75 CD cord-005453-4057qib7 6367 16 % % NN cord-005453-4057qib7 6367 17 vs. vs. CC cord-005453-4057qib7 6367 18 63 63 CD cord-005453-4057qib7 6367 19 % % NN cord-005453-4057qib7 6367 20 ) ) -RRB- cord-005453-4057qib7 6367 21 however however RB cord-005453-4057qib7 6367 22 without without IN cord-005453-4057qib7 6367 23 any any DT cord-005453-4057qib7 6367 24 statistical statistical JJ cord-005453-4057qib7 6367 25 significance significance NN cord-005453-4057qib7 6367 26 . . . cord-005453-4057qib7 6368 1 Ten ten CD cord-005453-4057qib7 6368 2 patients patient NNS cord-005453-4057qib7 6368 3 succumbed succumb VBD cord-005453-4057qib7 6368 4 to to IN cord-005453-4057qib7 6368 5 NRM NRM NNP cord-005453-4057qib7 6368 6 causes cause NNS cord-005453-4057qib7 6368 7 ; ; : cord-005453-4057qib7 6368 8 6/10 6/10 CD cord-005453-4057qib7 6368 9 deaths death NNS cord-005453-4057qib7 6368 10 attributed attribute VBN cord-005453-4057qib7 6368 11 to to IN cord-005453-4057qib7 6368 12 GvHD GvHD NNP cord-005453-4057qib7 6368 13 complications complication NNS cord-005453-4057qib7 6368 14 . . . cord-005453-4057qib7 6369 1 The the DT cord-005453-4057qib7 6369 2 NRM NRM NNP cord-005453-4057qib7 6369 3 was be VBD cord-005453-4057qib7 6369 4 assessed assess VBN cord-005453-4057qib7 6369 5 higher high JJR cord-005453-4057qib7 6369 6 in in IN cord-005453-4057qib7 6369 7 the the DT cord-005453-4057qib7 6369 8 high high JJ cord-005453-4057qib7 6369 9 - - HYPH cord-005453-4057qib7 6369 10 UA ua NN cord-005453-4057qib7 6369 11 group group NN cord-005453-4057qib7 6369 12 ( ( -LRB- cord-005453-4057qib7 6369 13 38 38 CD cord-005453-4057qib7 6369 14 % % NN cord-005453-4057qib7 6369 15 vs. vs. IN cord-005453-4057qib7 6369 16 18 18 CD cord-005453-4057qib7 6369 17 % % NN cord-005453-4057qib7 6369 18 ) ) -RRB- cord-005453-4057qib7 6369 19 but but CC cord-005453-4057qib7 6369 20 also also RB cord-005453-4057qib7 6369 21 this this DT cord-005453-4057qib7 6369 22 difference difference NN cord-005453-4057qib7 6369 23 was be VBD cord-005453-4057qib7 6369 24 not not RB cord-005453-4057qib7 6369 25 statistically statistically RB cord-005453-4057qib7 6369 26 significant significant JJ cord-005453-4057qib7 6369 27 . . . cord-005453-4057qib7 6370 1 Conclusions conclusion NNS cord-005453-4057qib7 6370 2 : : : cord-005453-4057qib7 6371 1 Though though IN cord-005453-4057qib7 6371 2 our -PRON- PRP$ cord-005453-4057qib7 6371 3 study study NN cord-005453-4057qib7 6371 4 bears bear VBZ cord-005453-4057qib7 6371 5 the the DT cord-005453-4057qib7 6371 6 limitations limitation NNS cord-005453-4057qib7 6371 7 of of IN cord-005453-4057qib7 6371 8 the the DT cord-005453-4057qib7 6371 9 small small JJ cord-005453-4057qib7 6371 10 number number NN cord-005453-4057qib7 6371 11 of of IN cord-005453-4057qib7 6371 12 patients patient NNS cord-005453-4057qib7 6371 13 and and CC cord-005453-4057qib7 6371 14 the the DT cord-005453-4057qib7 6371 15 retrospective retrospective JJ cord-005453-4057qib7 6371 16 origin origin NN cord-005453-4057qib7 6371 17 , , , cord-005453-4057qib7 6371 18 at at IN cord-005453-4057qib7 6371 19 least least JJS cord-005453-4057qib7 6371 20 to to IN cord-005453-4057qib7 6371 21 our -PRON- PRP$ cord-005453-4057qib7 6371 22 knowledge knowledge NN cord-005453-4057qib7 6371 23 is be VBZ cord-005453-4057qib7 6371 24 the the DT cord-005453-4057qib7 6371 25 first first JJ cord-005453-4057qib7 6371 26 which which WDT cord-005453-4057qib7 6371 27 evaluates evaluate VBZ cord-005453-4057qib7 6371 28 the the DT cord-005453-4057qib7 6371 29 impact impact NN cord-005453-4057qib7 6371 30 of of IN cord-005453-4057qib7 6371 31 UA UA NNP cord-005453-4057qib7 6371 32 levels level NNS cord-005453-4057qib7 6371 33 at at IN cord-005453-4057qib7 6371 34 different different JJ cord-005453-4057qib7 6371 35 time time NN cord-005453-4057qib7 6371 36 points point NNS cord-005453-4057qib7 6371 37 in in IN cord-005453-4057qib7 6371 38 the the DT cord-005453-4057qib7 6371 39 peritransplant peritransplant JJ cord-005453-4057qib7 6371 40 period period NN cord-005453-4057qib7 6371 41 , , , cord-005453-4057qib7 6371 42 on on IN cord-005453-4057qib7 6371 43 the the DT cord-005453-4057qib7 6371 44 aGvHD agvhd NN cord-005453-4057qib7 6371 45 incidence incidence NN cord-005453-4057qib7 6371 46 . . . cord-005453-4057qib7 6372 1 In in IN cord-005453-4057qib7 6372 2 our -PRON- PRP$ cord-005453-4057qib7 6372 3 study study NN cord-005453-4057qib7 6372 4 the the DT cord-005453-4057qib7 6372 5 UA UA NNP cord-005453-4057qib7 6372 6 levels level NNS cord-005453-4057qib7 6372 7 did do VBD cord-005453-4057qib7 6372 8 not not RB cord-005453-4057qib7 6372 9 influence influence VB cord-005453-4057qib7 6372 10 the the DT cord-005453-4057qib7 6372 11 incidence incidence NN cord-005453-4057qib7 6372 12 or or CC cord-005453-4057qib7 6372 13 the the DT cord-005453-4057qib7 6372 14 severity severity NN cord-005453-4057qib7 6372 15 of of IN cord-005453-4057qib7 6372 16 aGvHD agvhd NN cord-005453-4057qib7 6372 17 . . . cord-005453-4057qib7 6373 1 The the DT cord-005453-4057qib7 6373 2 higher high JJR cord-005453-4057qib7 6373 3 NRM NRM NNP cord-005453-4057qib7 6373 4 rates rate NNS cord-005453-4057qib7 6373 5 for for IN cord-005453-4057qib7 6373 6 patients patient NNS cord-005453-4057qib7 6373 7 with with IN cord-005453-4057qib7 6374 1 UA>3.0 UA>3.0 NNP cord-005453-4057qib7 6374 2 mg mg NNP cord-005453-4057qib7 6374 3 / / SYM cord-005453-4057qib7 6374 4 dl dl NNP cord-005453-4057qib7 6374 5 merits merit VBZ cord-005453-4057qib7 6374 6 further further JJ cord-005453-4057qib7 6374 7 evaluation evaluation NN cord-005453-4057qib7 6374 8 . . . cord-005453-4057qib7 6375 1 Definitely definitely RB cord-005453-4057qib7 6375 2 , , , cord-005453-4057qib7 6375 3 the the DT cord-005453-4057qib7 6375 4 role role NN cord-005453-4057qib7 6375 5 of of IN cord-005453-4057qib7 6375 6 UA UA NNP cord-005453-4057qib7 6375 7 on on IN cord-005453-4057qib7 6375 8 the the DT cord-005453-4057qib7 6375 9 alloSCT alloSCT NNP cord-005453-4057qib7 6375 10 outcome outcome NN cord-005453-4057qib7 6375 11 will will MD cord-005453-4057qib7 6375 12 be be VB cord-005453-4057qib7 6375 13 clarified clarify VBN cord-005453-4057qib7 6375 14 through through IN cord-005453-4057qib7 6375 15 well well RB cord-005453-4057qib7 6375 16 designed design VBN cord-005453-4057qib7 6375 17 prospective prospective JJ cord-005453-4057qib7 6375 18 trials trial NNS cord-005453-4057qib7 6375 19 . . . cord-005453-4057qib7 6376 1 Disclosure disclosure NN cord-005453-4057qib7 6376 2 Results result NNS cord-005453-4057qib7 6376 3 : : : cord-005453-4057qib7 6377 1 Five five CD cord-005453-4057qib7 6377 2 male male JJ cord-005453-4057qib7 6377 3 patients patient NNS cord-005453-4057qib7 6377 4 ( ( -LRB- cord-005453-4057qib7 6377 5 12 12 CD cord-005453-4057qib7 6377 6 % % NN cord-005453-4057qib7 6377 7 ) ) -RRB- cord-005453-4057qib7 6377 8 had have VBD cord-005453-4057qib7 6377 9 genital genital JJ cord-005453-4057qib7 6377 10 cGVHD cgvhd JJ cord-005453-4057qib7 6377 11 manifestations manifestation NNS cord-005453-4057qib7 6377 12 presented present VBN cord-005453-4057qib7 6377 13 by by IN cord-005453-4057qib7 6377 14 urethral urethral JJ cord-005453-4057qib7 6377 15 stricture stricture NN cord-005453-4057qib7 6377 16 in in IN cord-005453-4057qib7 6377 17 4/5 4/5 CD cord-005453-4057qib7 6377 18 patients patient NNS cord-005453-4057qib7 6377 19 and and CC cord-005453-4057qib7 6377 20 phimosis phimosis NN cord-005453-4057qib7 6377 21 requiring require VBG cord-005453-4057qib7 6377 22 surgical surgical JJ cord-005453-4057qib7 6377 23 treatment treatment NN cord-005453-4057qib7 6377 24 in in IN cord-005453-4057qib7 6377 25 one one CD cord-005453-4057qib7 6377 26 patient patient NN cord-005453-4057qib7 6377 27 . . . cord-005453-4057qib7 6378 1 All all DT cord-005453-4057qib7 6378 2 five five CD cord-005453-4057qib7 6378 3 patients patient NNS cord-005453-4057qib7 6378 4 had have VBD cord-005453-4057qib7 6378 5 simultaneously simultaneously RB cord-005453-4057qib7 6378 6 cutaneous cutaneous JJ cord-005453-4057qib7 6378 7 , , , cord-005453-4057qib7 6378 8 oral oral JJ cord-005453-4057qib7 6378 9 , , , cord-005453-4057qib7 6378 10 and/or and/or CC cord-005453-4057qib7 6378 11 ocular ocular JJ cord-005453-4057qib7 6378 12 cGVHD cgvhd NN cord-005453-4057qib7 6378 13 manifestations manifestation NNS cord-005453-4057qib7 6378 14 . . . cord-005453-4057qib7 6379 1 The the DT cord-005453-4057qib7 6379 2 first first JJ cord-005453-4057qib7 6379 3 patient patient NN cord-005453-4057qib7 6379 4 underwent undergo VBD cord-005453-4057qib7 6379 5 urethroplasty urethroplasty NNP cord-005453-4057qib7 6379 6 of of IN cord-005453-4057qib7 6379 7 bulbomembranous bulbomembranous JJ cord-005453-4057qib7 6379 8 part part NN cord-005453-4057qib7 6379 9 of of IN cord-005453-4057qib7 6379 10 urethra urethra NN cord-005453-4057qib7 6379 11 with with IN cord-005453-4057qib7 6379 12 termino termino JJ cord-005453-4057qib7 6379 13 - - JJ cord-005453-4057qib7 6379 14 terminal terminal JJ cord-005453-4057qib7 6379 15 anastomosis anastomosis NN cord-005453-4057qib7 6379 16 and and CC cord-005453-4057qib7 6379 17 urethroplasty urethroplasty NN cord-005453-4057qib7 6379 18 of of IN cord-005453-4057qib7 6379 19 penile penile JJ cord-005453-4057qib7 6379 20 part part NN cord-005453-4057qib7 6379 21 of of IN cord-005453-4057qib7 6379 22 urethra urethra NN cord-005453-4057qib7 6379 23 with with IN cord-005453-4057qib7 6379 24 buccal buccal JJ cord-005453-4057qib7 6379 25 mucosa mucosa JJ cord-005453-4057qib7 6379 26 autograft autograft NN cord-005453-4057qib7 6379 27 -BMG -BMG -RRB- cord-005453-4057qib7 6379 28 ( ( -LRB- cord-005453-4057qib7 6379 29 dorsal dorsal JJ cord-005453-4057qib7 6379 30 onlay onlay NN cord-005453-4057qib7 6379 31 ) ) -RRB- cord-005453-4057qib7 6379 32 that that WDT cord-005453-4057qib7 6379 33 resulted result VBD cord-005453-4057qib7 6379 34 in in IN cord-005453-4057qib7 6379 35 significant significant JJ cord-005453-4057qib7 6379 36 improvement improvement NN cord-005453-4057qib7 6379 37 of of IN cord-005453-4057qib7 6379 38 symptoms symptom NNS cord-005453-4057qib7 6379 39 and and CC cord-005453-4057qib7 6379 40 normal normal JJ cord-005453-4057qib7 6379 41 miction miction NN cord-005453-4057qib7 6379 42 afterwards afterwards RB cord-005453-4057qib7 6379 43 . . . cord-005453-4057qib7 6380 1 Biopsy biopsy NN cord-005453-4057qib7 6380 2 of of IN cord-005453-4057qib7 6380 3 the the DT cord-005453-4057qib7 6380 4 urethra urethra NN cord-005453-4057qib7 6380 5 showed show VBD cord-005453-4057qib7 6380 6 mononuclear mononuclear JJ cord-005453-4057qib7 6380 7 infiltration infiltration NN cord-005453-4057qib7 6380 8 in in IN cord-005453-4057qib7 6380 9 lamina lamina NNP cord-005453-4057qib7 6380 10 propria propria FW cord-005453-4057qib7 6380 11 consistent consistent JJ cord-005453-4057qib7 6380 12 with with IN cord-005453-4057qib7 6380 13 cGVHD cGVHD NNP cord-005453-4057qib7 6380 14 . . . cord-005453-4057qib7 6381 1 Biopsy biopsy NN cord-005453-4057qib7 6381 2 of of IN cord-005453-4057qib7 6381 3 the the DT cord-005453-4057qib7 6381 4 buccal buccal JJ cord-005453-4057qib7 6381 5 mucosa mucosa NN cord-005453-4057qib7 6381 6 was be VBD cord-005453-4057qib7 6381 7 done do VBN cord-005453-4057qib7 6381 8 prior prior RB cord-005453-4057qib7 6381 9 to to IN cord-005453-4057qib7 6381 10 surgery surgery NN cord-005453-4057qib7 6381 11 and and CC cord-005453-4057qib7 6381 12 was be VBD cord-005453-4057qib7 6381 13 negative negative JJ cord-005453-4057qib7 6381 14 for for IN cord-005453-4057qib7 6381 15 cGVHD cGVHD NNP cord-005453-4057qib7 6381 16 involvement involvement NN cord-005453-4057qib7 6381 17 . . . cord-005453-4057qib7 6382 1 The the DT cord-005453-4057qib7 6382 2 second second JJ cord-005453-4057qib7 6382 3 patient patient NN cord-005453-4057qib7 6382 4 underwent undergo VBD cord-005453-4057qib7 6382 5 urethrotomy urethrotomy NN cord-005453-4057qib7 6382 6 due due IN cord-005453-4057qib7 6382 7 to to IN cord-005453-4057qib7 6382 8 circular circular JJ cord-005453-4057qib7 6382 9 strictures stricture NNS cord-005453-4057qib7 6382 10 , , , cord-005453-4057qib7 6382 11 but but CC cord-005453-4057qib7 6382 12 symptoms symptom NNS cord-005453-4057qib7 6382 13 reappeared reappear VBD cord-005453-4057qib7 6382 14 again again RB cord-005453-4057qib7 6382 15 and and CC cord-005453-4057qib7 6382 16 he -PRON- PRP cord-005453-4057qib7 6382 17 is be VBZ cord-005453-4057qib7 6382 18 now now RB cord-005453-4057qib7 6382 19 candidate candidate NN cord-005453-4057qib7 6382 20 for for IN cord-005453-4057qib7 6382 21 BMG BMG NNP cord-005453-4057qib7 6382 22 . . . cord-005453-4057qib7 6383 1 In in IN cord-005453-4057qib7 6383 2 two two CD cord-005453-4057qib7 6383 3 patients patient NNS cord-005453-4057qib7 6383 4 urethral urethral JJ cord-005453-4057qib7 6383 5 dilatation dilatation NN cord-005453-4057qib7 6383 6 was be VBD cord-005453-4057qib7 6383 7 done do VBN cord-005453-4057qib7 6383 8 , , , cord-005453-4057qib7 6383 9 and and CC cord-005453-4057qib7 6383 10 the the DT cord-005453-4057qib7 6383 11 fifth fifth JJ cord-005453-4057qib7 6383 12 patient patient NN cord-005453-4057qib7 6383 13 presented present VBN cord-005453-4057qib7 6383 14 with with IN cord-005453-4057qib7 6383 15 phimosis phimosis NN cord-005453-4057qib7 6383 16 requiring require VBG cord-005453-4057qib7 6383 17 circumcision circumcision NN cord-005453-4057qib7 6383 18 , , , cord-005453-4057qib7 6383 19 resulted result VBD cord-005453-4057qib7 6383 20 in in IN cord-005453-4057qib7 6383 21 significant significant JJ cord-005453-4057qib7 6383 22 improvement improvement NN cord-005453-4057qib7 6383 23 of of IN cord-005453-4057qib7 6383 24 symptoms symptom NNS cord-005453-4057qib7 6383 25 . . . cord-005453-4057qib7 6384 1 Conclusions conclusion NNS cord-005453-4057qib7 6384 2 : : : cord-005453-4057qib7 6385 1 Male male JJ cord-005453-4057qib7 6385 2 genital genital JJ cord-005453-4057qib7 6385 3 cGVHD cgvhd NN cord-005453-4057qib7 6385 4 is be VBZ cord-005453-4057qib7 6385 5 an an DT cord-005453-4057qib7 6385 6 underrecognized underrecognized JJ cord-005453-4057qib7 6385 7 and and CC cord-005453-4057qib7 6385 8 under under RB cord-005453-4057qib7 6385 9 - - HYPH cord-005453-4057qib7 6385 10 reported report VBN cord-005453-4057qib7 6385 11 manifestation manifestation NN cord-005453-4057qib7 6385 12 . . . cord-005453-4057qib7 6386 1 Patients patient NNS cord-005453-4057qib7 6386 2 after after IN cord-005453-4057qib7 6386 3 allo allo NN cord-005453-4057qib7 6386 4 - - HYPH cord-005453-4057qib7 6386 5 HSCT HSCT NNP cord-005453-4057qib7 6386 6 need need VBP cord-005453-4057qib7 6386 7 to to TO cord-005453-4057qib7 6386 8 be be VB cord-005453-4057qib7 6386 9 actively actively RB cord-005453-4057qib7 6386 10 asked ask VBN cord-005453-4057qib7 6386 11 about about IN cord-005453-4057qib7 6386 12 their -PRON- PRP$ cord-005453-4057qib7 6386 13 genital genital JJ cord-005453-4057qib7 6386 14 symptoms symptom NNS cord-005453-4057qib7 6386 15 and and CC cord-005453-4057qib7 6386 16 sexual sexual JJ cord-005453-4057qib7 6386 17 function function NN cord-005453-4057qib7 6386 18 , , , cord-005453-4057qib7 6386 19 especially especially RB cord-005453-4057qib7 6386 20 if if IN cord-005453-4057qib7 6386 21 they -PRON- PRP cord-005453-4057qib7 6386 22 are be VBP cord-005453-4057qib7 6386 23 diagnosed diagnose VBN cord-005453-4057qib7 6386 24 with with IN cord-005453-4057qib7 6386 25 other other JJ cord-005453-4057qib7 6386 26 mucocutaneous mucocutaneous JJ cord-005453-4057qib7 6386 27 or or CC cord-005453-4057qib7 6386 28 ocular ocular JJ cord-005453-4057qib7 6386 29 cGVHD cgvhd NN cord-005453-4057qib7 6386 30 . . . cord-005453-4057qib7 6387 1 Multidisciplinary multidisciplinary JJ cord-005453-4057qib7 6387 2 approach approach NN cord-005453-4057qib7 6387 3 , , , cord-005453-4057qib7 6387 4 early early JJ cord-005453-4057qib7 6387 5 recognition recognition NN cord-005453-4057qib7 6387 6 and and CC cord-005453-4057qib7 6387 7 frequent frequent JJ cord-005453-4057qib7 6387 8 follow follow NN cord-005453-4057qib7 6387 9 - - HYPH cord-005453-4057qib7 6387 10 up up NN cord-005453-4057qib7 6387 11 is be VBZ cord-005453-4057qib7 6387 12 necessary necessary JJ cord-005453-4057qib7 6387 13 for for IN cord-005453-4057qib7 6387 14 timely timely JJ cord-005453-4057qib7 6387 15 start start NN cord-005453-4057qib7 6387 16 of of IN cord-005453-4057qib7 6387 17 treatment treatment NN cord-005453-4057qib7 6387 18 . . . cord-005453-4057qib7 6388 1 New new JJ cord-005453-4057qib7 6388 2 methods method NNS cord-005453-4057qib7 6388 3 , , , cord-005453-4057qib7 6388 4 such such JJ cord-005453-4057qib7 6388 5 as as IN cord-005453-4057qib7 6388 6 BMG BMG NNP cord-005453-4057qib7 6388 7 for for IN cord-005453-4057qib7 6388 8 cGVHD cGVHD NNP cord-005453-4057qib7 6388 9 patients patient NNS cord-005453-4057qib7 6388 10 with with IN cord-005453-4057qib7 6388 11 urethral urethral JJ cord-005453-4057qib7 6388 12 stricture stricture NN cord-005453-4057qib7 6388 13 seem seem VBP cord-005453-4057qib7 6388 14 promising promise VBG cord-005453-4057qib7 6388 15 and and CC cord-005453-4057qib7 6388 16 should should MD cord-005453-4057qib7 6388 17 be be VB cord-005453-4057qib7 6388 18 further further RB cord-005453-4057qib7 6388 19 investigated investigate VBN cord-005453-4057qib7 6388 20 . . . cord-005453-4057qib7 6389 1 Disclosure disclosure NN cord-005453-4057qib7 6389 2 : : : cord-005453-4057qib7 6389 3 Nothing nothing NN cord-005453-4057qib7 6389 4 to to TO cord-005453-4057qib7 6389 5 declare declare VB cord-005453-4057qib7 6389 6 . . . cord-005453-4057qib7 6390 1 P289 P289 NNP cord-005453-4057qib7 6390 2 Abstract Abstract NNP cord-005453-4057qib7 6390 3 withdrawn withdraw VBN cord-005453-4057qib7 6390 4 . . . cord-005453-4057qib7 6391 1 Heracles Heracles NNP cord-005453-4057qib7 6391 2 : : : cord-005453-4057qib7 6392 1 A a DT cord-005453-4057qib7 6392 2 phase phase NN cord-005453-4057qib7 6392 3 II ii CD cord-005453-4057qib7 6392 4 single single JJ cord-005453-4057qib7 6392 5 - - HYPH cord-005453-4057qib7 6392 6 arm arm NN cord-005453-4057qib7 6392 7 prospective prospective JJ cord-005453-4057qib7 6392 8 study study NN cord-005453-4057qib7 6392 9 to to TO cord-005453-4057qib7 6392 10 assess assess VB cord-005453-4057qib7 6392 11 the the DT cord-005453-4057qib7 6392 12 efficacy efficacy NN cord-005453-4057qib7 6392 13 of of IN cord-005453-4057qib7 6392 14 fecal fecal JJ cord-005453-4057qib7 6392 15 microbiota microbiota NN cord-005453-4057qib7 6392 16 transfer transfer NN cord-005453-4057qib7 6392 17 in in IN cord-005453-4057qib7 6392 18 the the DT cord-005453-4057qib7 6392 19 treatment treatment NN cord-005453-4057qib7 6392 20 of of IN cord-005453-4057qib7 6392 21 steroid steroid NN cord-005453-4057qib7 6392 22 refractory refractory JJ cord-005453-4057qib7 6392 23 gastro gastro JJ cord-005453-4057qib7 6392 24 - - HYPH cord-005453-4057qib7 6392 25 intestinal intestinal JJ cord-005453-4057qib7 6392 26 AGVHD AGVHD NNP cord-005453-4057qib7 6392 27 post post AFX cord-005453-4057qib7 6392 28 allo allo NN cord-005453-4057qib7 6392 29 - - HYPH cord-005453-4057qib7 6392 30 HSCT HSCT NNP cord-005453-4057qib7 6392 31 Background Background NNP cord-005453-4057qib7 6392 32 : : : cord-005453-4057qib7 6392 33 Steroid steroid JJ cord-005453-4057qib7 6392 34 - - HYPH cord-005453-4057qib7 6392 35 refractory refractory JJ cord-005453-4057qib7 6392 36 acute acute JJ cord-005453-4057qib7 6392 37 graft graft NN cord-005453-4057qib7 6392 38 - - HYPH cord-005453-4057qib7 6392 39 versus versus IN cord-005453-4057qib7 6392 40 - - HYPH cord-005453-4057qib7 6392 41 host host NN cord-005453-4057qib7 6392 42 disease disease NN cord-005453-4057qib7 6392 43 ( ( -LRB- cord-005453-4057qib7 6392 44 SR SR NNP cord-005453-4057qib7 6392 45 - - HYPH cord-005453-4057qib7 6392 46 aGVHD aGVHD NNP cord-005453-4057qib7 6392 47 ) ) -RRB- cord-005453-4057qib7 6392 48 is be VBZ cord-005453-4057qib7 6392 49 associated associate VBN cord-005453-4057qib7 6392 50 with with IN cord-005453-4057qib7 6392 51 an an DT cord-005453-4057qib7 6392 52 80 80 CD cord-005453-4057qib7 6392 53 % % NN cord-005453-4057qib7 6392 54 mortality mortality NN cord-005453-4057qib7 6392 55 rate rate NN cord-005453-4057qib7 6392 56 and and CC cord-005453-4057qib7 6392 57 reduced reduced JJ cord-005453-4057qib7 6392 58 quality quality NN cord-005453-4057qib7 6392 59 of of IN cord-005453-4057qib7 6392 60 life life NN cord-005453-4057qib7 6392 61 ( ( -LRB- cord-005453-4057qib7 6392 62 QoL qol NN cord-005453-4057qib7 6392 63 ) ) -RRB- cord-005453-4057qib7 6392 64 . . . cord-005453-4057qib7 6393 1 So so RB cord-005453-4057qib7 6393 2 far far RB cord-005453-4057qib7 6393 3 , , , cord-005453-4057qib7 6393 4 there there EX cord-005453-4057qib7 6393 5 is be VBZ cord-005453-4057qib7 6393 6 no no DT cord-005453-4057qib7 6393 7 approved approve VBN cord-005453-4057qib7 6393 8 standard standard NN cord-005453-4057qib7 6393 9 of of IN cord-005453-4057qib7 6393 10 care care NN cord-005453-4057qib7 6393 11 for for IN cord-005453-4057qib7 6393 12 aGVHD aGVHD NNP cord-005453-4057qib7 6393 13 second second JJ cord-005453-4057qib7 6393 14 - - HYPH cord-005453-4057qib7 6393 15 line line NN cord-005453-4057qib7 6393 16 treatment treatment NN cord-005453-4057qib7 6393 17 . . . cord-005453-4057qib7 6394 1 There there EX cord-005453-4057qib7 6394 2 is be VBZ cord-005453-4057qib7 6394 3 an an DT cord-005453-4057qib7 6394 4 urgent urgent JJ cord-005453-4057qib7 6394 5 need need NN cord-005453-4057qib7 6394 6 to to TO cord-005453-4057qib7 6394 7 identify identify VB cord-005453-4057qib7 6394 8 effective effective JJ cord-005453-4057qib7 6394 9 therapy therapy NN cord-005453-4057qib7 6394 10 for for IN cord-005453-4057qib7 6394 11 SR SR NNP cord-005453-4057qib7 6394 12 - - HYPH cord-005453-4057qib7 6394 13 aGVHD aGVHD NNP cord-005453-4057qib7 6394 14 to to TO cord-005453-4057qib7 6394 15 improve improve VB cord-005453-4057qib7 6394 16 patients patient NNS cord-005453-4057qib7 6394 17 ' ' POS cord-005453-4057qib7 6394 18 outcomes outcome NNS cord-005453-4057qib7 6394 19 . . . cord-005453-4057qib7 6395 1 Fecal Fecal NNP cord-005453-4057qib7 6395 2 Microbiota Microbiota NNP cord-005453-4057qib7 6395 3 Transfer Transfer NNP cord-005453-4057qib7 6395 4 ( ( -LRB- cord-005453-4057qib7 6395 5 FMT fmt NN cord-005453-4057qib7 6395 6 ) ) -RRB- cord-005453-4057qib7 6395 7 might may MD cord-005453-4057qib7 6395 8 be be VB cord-005453-4057qib7 6395 9 beneficial beneficial JJ cord-005453-4057qib7 6395 10 to to TO cord-005453-4057qib7 6395 11 substantially substantially RB cord-005453-4057qib7 6395 12 improve improve VB cord-005453-4057qib7 6395 13 the the DT cord-005453-4057qib7 6395 14 prognosis prognosis NN cord-005453-4057qib7 6395 15 . . . cord-005453-4057qib7 6396 1 Higher high JJR cord-005453-4057qib7 6396 2 gut gut NN cord-005453-4057qib7 6396 3 microbial microbial JJ cord-005453-4057qib7 6396 4 diversity diversity NN cord-005453-4057qib7 6396 5 is be VBZ cord-005453-4057qib7 6396 6 strongly strongly RB cord-005453-4057qib7 6396 7 associated associate VBN cord-005453-4057qib7 6396 8 with with IN cord-005453-4057qib7 6396 9 increased increase VBN cord-005453-4057qib7 6396 10 survival survival NN cord-005453-4057qib7 6396 11 in in IN cord-005453-4057qib7 6396 12 GvHD gvhd NN cord-005453-4057qib7 6396 13 patients patient NNS cord-005453-4057qib7 6396 14 . . . cord-005453-4057qib7 6397 1 Recent recent JJ cord-005453-4057qib7 6397 2 studies study NNS cord-005453-4057qib7 6397 3 reported report VBD cord-005453-4057qib7 6397 4 promising promising JJ cord-005453-4057qib7 6397 5 results result NNS cord-005453-4057qib7 6397 6 of of IN cord-005453-4057qib7 6397 7 SR SR NNP cord-005453-4057qib7 6397 8 - - HYPH cord-005453-4057qib7 6397 9 aGVHD aGVHD NNP cord-005453-4057qib7 6397 10 patients patient NNS cord-005453-4057qib7 6397 11 treated treat VBN cord-005453-4057qib7 6397 12 with with IN cord-005453-4057qib7 6397 13 FMT FMT NNP cord-005453-4057qib7 6397 14 . . . cord-005453-4057qib7 6398 1 Further further JJ cord-005453-4057qib7 6398 2 evaluation evaluation NN cord-005453-4057qib7 6398 3 to to TO cord-005453-4057qib7 6398 4 confirm confirm VB cord-005453-4057qib7 6398 5 the the DT cord-005453-4057qib7 6398 6 efficacy efficacy NN cord-005453-4057qib7 6398 7 and and CC cord-005453-4057qib7 6398 8 safety safety NN cord-005453-4057qib7 6398 9 of of IN cord-005453-4057qib7 6398 10 FMT fmt NN cord-005453-4057qib7 6398 11 for for IN cord-005453-4057qib7 6398 12 aGVHD aGVHD NNP cord-005453-4057qib7 6398 13 is be VBZ cord-005453-4057qib7 6398 14 warranted warrant VBN cord-005453-4057qib7 6398 15 . . . cord-005453-4057qib7 6399 1 The the DT cord-005453-4057qib7 6399 2 ongoing ongoing JJ cord-005453-4057qib7 6399 3 phase phase NN cord-005453-4057qib7 6399 4 2 2 CD cord-005453-4057qib7 6399 5 study study NN cord-005453-4057qib7 6399 6 ( ( -LRB- cord-005453-4057qib7 6399 7 HERACLES HERACLES NNP cord-005453-4057qib7 6399 8 ) ) -RRB- cord-005453-4057qib7 6399 9 investigates investigate VBZ cord-005453-4057qib7 6399 10 the the DT cord-005453-4057qib7 6399 11 efficacy efficacy NN cord-005453-4057qib7 6399 12 of of IN cord-005453-4057qib7 6399 13 allogeneic allogeneic NN cord-005453-4057qib7 6399 14 FMT fmt NN cord-005453-4057qib7 6399 15 in in IN cord-005453-4057qib7 6399 16 the the DT cord-005453-4057qib7 6399 17 treatment treatment NN cord-005453-4057qib7 6399 18 of of IN cord-005453-4057qib7 6399 19 patients patient NNS cord-005453-4057qib7 6399 20 with with IN cord-005453-4057qib7 6399 21 SR SR NNP cord-005453-4057qib7 6399 22 - - HYPH cord-005453-4057qib7 6399 23 aGVHD aGVHD NNP cord-005453-4057qib7 6399 24 . . . cord-005453-4057qib7 6400 1 HERACLES HERACLES NNP cord-005453-4057qib7 6400 2 was be VBD cord-005453-4057qib7 6400 3 launched launch VBN cord-005453-4057qib7 6400 4 after after IN cord-005453-4057qib7 6400 5 the the DT cord-005453-4057qib7 6400 6 ODYSSEE ODYSSEE NNP cord-005453-4057qib7 6400 7 study study NN cord-005453-4057qib7 6400 8 showed show VBD cord-005453-4057qib7 6400 9 promising promising JJ cord-005453-4057qib7 6400 10 results result NNS cord-005453-4057qib7 6400 11 in in IN cord-005453-4057qib7 6400 12 the the DT cord-005453-4057qib7 6400 13 reconstruction reconstruction NN cord-005453-4057qib7 6400 14 of of IN cord-005453-4057qib7 6400 15 gut gut NN cord-005453-4057qib7 6400 16 microbiota microbiota NN cord-005453-4057qib7 6400 17 diversity diversity NN cord-005453-4057qib7 6400 18 after after IN cord-005453-4057qib7 6400 19 induction induction NN cord-005453-4057qib7 6400 20 chemotherapy chemotherapy NN cord-005453-4057qib7 6400 21 with with IN cord-005453-4057qib7 6400 22 FMT fmt NN cord-005453-4057qib7 6400 23 in in IN cord-005453-4057qib7 6400 24 Acute Acute NNP cord-005453-4057qib7 6400 25 Myeloid Myeloid NNP cord-005453-4057qib7 6400 26 Leukemia Leukemia NNP cord-005453-4057qib7 6400 27 patients patient NNS cord-005453-4057qib7 6400 28 . . . cord-005453-4057qib7 6401 1 We -PRON- PRP cord-005453-4057qib7 6401 2 expect expect VBP cord-005453-4057qib7 6401 3 that that IN cord-005453-4057qib7 6401 4 FMT fmt NN cord-005453-4057qib7 6401 5 - - HYPH cord-005453-4057qib7 6401 6 based base VBN cord-005453-4057qib7 6401 7 biotherapeutic biotherapeutic JJ cord-005453-4057qib7 6401 8 drugs drug NNS cord-005453-4057qib7 6401 9 could could MD cord-005453-4057qib7 6401 10 be be VB cord-005453-4057qib7 6401 11 effective effective JJ cord-005453-4057qib7 6401 12 treatments treatment NNS cord-005453-4057qib7 6401 13 to to TO cord-005453-4057qib7 6401 14 contain contain VB cord-005453-4057qib7 6401 15 SR SR NNP cord-005453-4057qib7 6401 16 - - HYPH cord-005453-4057qib7 6401 17 aGVHD aGVHD NNP cord-005453-4057qib7 6401 18 , , , cord-005453-4057qib7 6401 19 and and CC cord-005453-4057qib7 6401 20 thereby thereby RB cord-005453-4057qib7 6401 21 reduce reduce VB cord-005453-4057qib7 6401 22 the the DT cord-005453-4057qib7 6401 23 risk risk NN cord-005453-4057qib7 6401 24 of of IN cord-005453-4057qib7 6401 25 life life NN cord-005453-4057qib7 6401 26 - - HYPH cord-005453-4057qib7 6401 27 threatening threaten VBG cord-005453-4057qib7 6401 28 complications complication NNS cord-005453-4057qib7 6401 29 after after IN cord-005453-4057qib7 6401 30 allogeneic allogeneic NN cord-005453-4057qib7 6401 31 HSCT HSCT NNP cord-005453-4057qib7 6401 32 . . . cord-005453-4057qib7 6402 1 Methods method NNS cord-005453-4057qib7 6402 2 : : : cord-005453-4057qib7 6402 3 HERACLES HERACLES NNP cord-005453-4057qib7 6402 4 is be VBZ cord-005453-4057qib7 6402 5 a a DT cord-005453-4057qib7 6402 6 single single JJ cord-005453-4057qib7 6402 7 - - HYPH cord-005453-4057qib7 6402 8 arm arm NN cord-005453-4057qib7 6402 9 , , , cord-005453-4057qib7 6402 10 multicenter multicenter JJ cord-005453-4057qib7 6402 11 prospective prospective JJ cord-005453-4057qib7 6402 12 trial trial NN cord-005453-4057qib7 6402 13 in in IN cord-005453-4057qib7 6402 14 5 5 CD cord-005453-4057qib7 6402 15 European european JJ cord-005453-4057qib7 6402 16 countries country NNS cord-005453-4057qib7 6402 17 . . . cord-005453-4057qib7 6403 1 Patients patient NNS cord-005453-4057qib7 6403 2 aged aged JJ cord-005453-4057qib7 6404 1 ≥18 ≥18 NNP cord-005453-4057qib7 6404 2 years year NNS cord-005453-4057qib7 6404 3 - - HYPH cord-005453-4057qib7 6404 4 old old JJ cord-005453-4057qib7 6404 5 , , , cord-005453-4057qib7 6404 6 who who WP cord-005453-4057qib7 6404 7 underwent undergo VBD cord-005453-4057qib7 6404 8 allogeneic allogeneic JJ cord-005453-4057qib7 6404 9 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 6404 10 Stem Stem NNP cord-005453-4057qib7 6404 11 Cell cell NN cord-005453-4057qib7 6404 12 Transplantation transplantation NN cord-005453-4057qib7 6404 13 ( ( -LRB- cord-005453-4057qib7 6404 14 allo allo NN cord-005453-4057qib7 6404 15 - - HYPH cord-005453-4057qib7 6404 16 HSCT HSCT NNP cord-005453-4057qib7 6404 17 ) ) -RRB- cord-005453-4057qib7 6404 18 and and CC cord-005453-4057qib7 6404 19 developed develop VBD cord-005453-4057qib7 6404 20 a a DT cord-005453-4057qib7 6404 21 first first JJ cord-005453-4057qib7 6404 22 episode episode NN cord-005453-4057qib7 6404 23 of of IN cord-005453-4057qib7 6404 24 Stage Stage NNP cord-005453-4057qib7 6404 25 3 3 CD cord-005453-4057qib7 6404 26 or or CC cord-005453-4057qib7 6404 27 4 4 CD cord-005453-4057qib7 6404 28 aGVHD agvhd NN cord-005453-4057qib7 6404 29 with with IN cord-005453-4057qib7 6404 30 gut gut NN cord-005453-4057qib7 6404 31 predominance predominance NN cord-005453-4057qib7 6404 32 resistant resistant JJ cord-005453-4057qib7 6404 33 to to IN cord-005453-4057qib7 6404 34 a a DT cord-005453-4057qib7 6404 35 first first JJ cord-005453-4057qib7 6404 36 - - HYPH cord-005453-4057qib7 6404 37 line line NN cord-005453-4057qib7 6404 38 steroid steroid NN cord-005453-4057qib7 6404 39 therapy therapy NN cord-005453-4057qib7 6404 40 are be VBP cord-005453-4057qib7 6404 41 eligible eligible JJ cord-005453-4057qib7 6404 42 for for IN cord-005453-4057qib7 6404 43 inclusion inclusion NN cord-005453-4057qib7 6404 44 . . . cord-005453-4057qib7 6405 1 Main main JJ cord-005453-4057qib7 6405 2 exclusion exclusion NN cord-005453-4057qib7 6405 3 criteria criterion NNS cord-005453-4057qib7 6405 4 comprise comprise VBP cord-005453-4057qib7 6405 5 the the DT cord-005453-4057qib7 6405 6 use use NN cord-005453-4057qib7 6405 7 of of IN cord-005453-4057qib7 6405 8 other other JJ cord-005453-4057qib7 6405 9 second second JJ cord-005453-4057qib7 6405 10 - - HYPH cord-005453-4057qib7 6405 11 line line NN cord-005453-4057qib7 6405 12 GVHD GVHD NNP cord-005453-4057qib7 6405 13 therapy therapy NN cord-005453-4057qib7 6405 14 , , , cord-005453-4057qib7 6405 15 patients patient NNS cord-005453-4057qib7 6405 16 with with IN cord-005453-4057qib7 6405 17 grade grade NN cord-005453-4057qib7 6405 18 IV IV NNP cord-005453-4057qib7 6405 19 hyperacute hyperacute JJ cord-005453-4057qib7 6405 20 GVHD GVHD NNP cord-005453-4057qib7 6405 21 , , , cord-005453-4057qib7 6405 22 late late JJ cord-005453-4057qib7 6405 23 onset onset NN cord-005453-4057qib7 6405 24 aGVHD agvhd NN cord-005453-4057qib7 6405 25 , , , cord-005453-4057qib7 6405 26 and and CC cord-005453-4057qib7 6405 27 overlap overlap VBP cord-005453-4057qib7 6405 28 chronic chronic JJ cord-005453-4057qib7 6405 29 GVHD GVHD NNP cord-005453-4057qib7 6405 30 and and CC cord-005453-4057qib7 6405 31 aGVHD agvhd NN cord-005453-4057qib7 6405 32 after after IN cord-005453-4057qib7 6405 33 donor donor NN cord-005453-4057qib7 6405 34 lymphocyte lymphocyte NN cord-005453-4057qib7 6405 35 infusion infusion NN cord-005453-4057qib7 6405 36 . . . cord-005453-4057qib7 6406 1 Patients patient NNS cord-005453-4057qib7 6406 2 receive receive VBP cord-005453-4057qib7 6406 3 a a DT cord-005453-4057qib7 6406 4 first first JJ cord-005453-4057qib7 6406 5 MaaT013 MaaT013 NNP cord-005453-4057qib7 6406 6 enema enema NN cord-005453-4057qib7 6406 7 within within IN cord-005453-4057qib7 6406 8 5 5 CD cord-005453-4057qib7 6406 9 days day NNS cord-005453-4057qib7 6406 10 after after IN cord-005453-4057qib7 6406 11 SR SR NNP cord-005453-4057qib7 6406 12 diagnosis diagnosis NN cord-005453-4057qib7 6406 13 ( ( -LRB- cord-005453-4057qib7 6406 14 V1 V1 NNS cord-005453-4057qib7 6406 15 ) ) -RRB- cord-005453-4057qib7 6406 16 and and CC cord-005453-4057qib7 6406 17 2 2 CD cord-005453-4057qib7 6406 18 additional additional JJ cord-005453-4057qib7 6406 19 ones one NNS cord-005453-4057qib7 6406 20 1 1 CD cord-005453-4057qib7 6406 21 week week NN cord-005453-4057qib7 6406 22 apart apart RB cord-005453-4057qib7 6406 23 ( ( -LRB- cord-005453-4057qib7 6406 24 V2/ V2/ NNP cord-005453-4057qib7 6406 25 V3 V3 NNP cord-005453-4057qib7 6406 26 ) ) -RRB- cord-005453-4057qib7 6406 27 from from IN cord-005453-4057qib7 6406 28 each each DT cord-005453-4057qib7 6406 29 other other JJ cord-005453-4057qib7 6406 30 . . . cord-005453-4057qib7 6407 1 MaaT013 MaaT013 NNP cord-005453-4057qib7 6407 2 is be VBZ cord-005453-4057qib7 6407 3 a a DT cord-005453-4057qib7 6407 4 highly highly RB cord-005453-4057qib7 6407 5 - - HYPH cord-005453-4057qib7 6407 6 diverse diverse JJ cord-005453-4057qib7 6407 7 , , , cord-005453-4057qib7 6407 8 microbiome microbiome NN cord-005453-4057qib7 6407 9 - - HYPH cord-005453-4057qib7 6407 10 rich rich JJ cord-005453-4057qib7 6407 11 enema enema NN cord-005453-4057qib7 6407 12 formulation formulation NN cord-005453-4057qib7 6407 13 obtained obtain VBN cord-005453-4057qib7 6407 14 from from IN cord-005453-4057qib7 6407 15 pooled pool VBN cord-005453-4057qib7 6407 16 , , , cord-005453-4057qib7 6407 17 rigorously rigorously RB cord-005453-4057qib7 6407 18 screened screen VBD cord-005453-4057qib7 6407 19 faeces faece NNS cord-005453-4057qib7 6407 20 from from IN cord-005453-4057qib7 6407 21 healthy healthy JJ cord-005453-4057qib7 6407 22 donors donor NNS cord-005453-4057qib7 6407 23 , , , cord-005453-4057qib7 6407 24 manufactured manufacture VBN cord-005453-4057qib7 6407 25 with with IN cord-005453-4057qib7 6407 26 a a DT cord-005453-4057qib7 6407 27 standardized standardized JJ cord-005453-4057qib7 6407 28 process process NN cord-005453-4057qib7 6407 29 using use VBG cord-005453-4057qib7 6407 30 the the DT cord-005453-4057qib7 6407 31 signature signature NN cord-005453-4057qib7 6407 32 MaaT MaaT NNP cord-005453-4057qib7 6407 33 Microbiome microbiome NN cord-005453-4057qib7 6407 34 Restoration Restoration NNP cord-005453-4057qib7 6407 35 Biotherapeutic Biotherapeutic NNP cord-005453-4057qib7 6407 36 ( ( -LRB- cord-005453-4057qib7 6407 37 MMRB MMRB NNP cord-005453-4057qib7 6407 38 ) ) -RRB- cord-005453-4057qib7 6407 39 platform platform NN cord-005453-4057qib7 6407 40 . . . cord-005453-4057qib7 6408 1 At at IN cord-005453-4057qib7 6408 2 inclusion inclusion NN cord-005453-4057qib7 6408 3 ( ( -LRB- cord-005453-4057qib7 6408 4 V1 V1 NNS cord-005453-4057qib7 6408 5 ) ) -RRB- cord-005453-4057qib7 6408 6 , , , cord-005453-4057qib7 6408 7 before before IN cord-005453-4057qib7 6408 8 each each DT cord-005453-4057qib7 6408 9 dosing dosing NN cord-005453-4057qib7 6408 10 ( ( -LRB- cord-005453-4057qib7 6408 11 V2,3 V2,3 NNP cord-005453-4057qib7 6408 12 ) ) -RRB- cord-005453-4057qib7 6408 13 , , , cord-005453-4057qib7 6408 14 and and CC cord-005453-4057qib7 6408 15 28 28 CD cord-005453-4057qib7 6408 16 days day NNS cord-005453-4057qib7 6408 17 post post NN cord-005453-4057qib7 6408 18 inclusion inclusion NN cord-005453-4057qib7 6408 19 ( ( -LRB- cord-005453-4057qib7 6408 20 V4 V4 NNP cord-005453-4057qib7 6408 21 ) ) -RRB- cord-005453-4057qib7 6408 22 , , , cord-005453-4057qib7 6408 23 patients patient NNS cord-005453-4057qib7 6408 24 ' ' POS cord-005453-4057qib7 6408 25 faeces faece NNS cord-005453-4057qib7 6408 26 and and CC cord-005453-4057qib7 6408 27 blood blood NN cord-005453-4057qib7 6408 28 are be VBP cord-005453-4057qib7 6408 29 collected collect VBN cord-005453-4057qib7 6408 30 . . . cord-005453-4057qib7 6409 1 Safety safety NN cord-005453-4057qib7 6409 2 monitoring monitoring NN cord-005453-4057qib7 6409 3 will will MD cord-005453-4057qib7 6409 4 be be VB cord-005453-4057qib7 6409 5 performed perform VBN cord-005453-4057qib7 6409 6 with with IN cord-005453-4057qib7 6409 7 corresponding correspond VBG cord-005453-4057qib7 6409 8 blood blood NN cord-005453-4057qib7 6409 9 analyses analysis NNS cord-005453-4057qib7 6409 10 . . . cord-005453-4057qib7 6410 1 Exploratory exploratory JJ cord-005453-4057qib7 6410 2 measures measure NNS cord-005453-4057qib7 6410 3 on on IN cord-005453-4057qib7 6410 4 faeces faece NNS cord-005453-4057qib7 6410 5 include include VBP cord-005453-4057qib7 6410 6 characterization characterization NN cord-005453-4057qib7 6410 7 of of IN cord-005453-4057qib7 6410 8 gut gut NN cord-005453-4057qib7 6410 9 microbiota microbiota NN cord-005453-4057qib7 6410 10 composition composition NN cord-005453-4057qib7 6410 11 and and CC cord-005453-4057qib7 6410 12 evolution evolution NN cord-005453-4057qib7 6410 13 , , , cord-005453-4057qib7 6410 14 impact impact NN cord-005453-4057qib7 6410 15 of of IN cord-005453-4057qib7 6410 16 MaaT013 MaaT013 NNP cord-005453-4057qib7 6410 17 on on IN cord-005453-4057qib7 6410 18 metabolism metabolism NN cord-005453-4057qib7 6410 19 , , , cord-005453-4057qib7 6410 20 and and CC cord-005453-4057qib7 6410 21 gut gut VB cord-005453-4057qib7 6410 22 inflammation inflammation NN cord-005453-4057qib7 6410 23 . . . cord-005453-4057qib7 6411 1 Immune immune JJ cord-005453-4057qib7 6411 2 system system NN cord-005453-4057qib7 6411 3 phenotyping phenotyping NN cord-005453-4057qib7 6411 4 will will MD cord-005453-4057qib7 6411 5 be be VB cord-005453-4057qib7 6411 6 performed perform VBN cord-005453-4057qib7 6411 7 by by IN cord-005453-4057qib7 6411 8 flow flow NN cord-005453-4057qib7 6411 9 cytometry cytometry NN cord-005453-4057qib7 6411 10 on on IN cord-005453-4057qib7 6411 11 peripheral peripheral JJ cord-005453-4057qib7 6411 12 blood blood NN cord-005453-4057qib7 6411 13 mononuclear mononuclear NN cord-005453-4057qib7 6411 14 cells cell NNS cord-005453-4057qib7 6411 15 , , , cord-005453-4057qib7 6411 16 and and CC cord-005453-4057qib7 6411 17 by by IN cord-005453-4057qib7 6411 18 ELISA ELISA NNP cord-005453-4057qib7 6411 19 assay assay NN cord-005453-4057qib7 6411 20 on on IN cord-005453-4057qib7 6411 21 plasma plasma NN cord-005453-4057qib7 6411 22 . . . cord-005453-4057qib7 6412 1 Patients patient NNS cord-005453-4057qib7 6412 2 ' ' POS cord-005453-4057qib7 6412 3 QoL qol NN cord-005453-4057qib7 6412 4 will will MD cord-005453-4057qib7 6412 5 be be VB cord-005453-4057qib7 6412 6 assessed assess VBN cord-005453-4057qib7 6412 7 using use VBG cord-005453-4057qib7 6412 8 a a DT cord-005453-4057qib7 6412 9 standard standard NN cord-005453-4057qib7 6412 10 , , , cord-005453-4057qib7 6412 11 EQ-5D-5L EQ-5D-5L NNP cord-005453-4057qib7 6412 12 questionnaire questionnaire NN cord-005453-4057qib7 6412 13 . . . cord-005453-4057qib7 6413 1 The the DT cord-005453-4057qib7 6413 2 primary primary JJ cord-005453-4057qib7 6413 3 objective objective NN cord-005453-4057qib7 6413 4 is be VBZ cord-005453-4057qib7 6413 5 to to TO cord-005453-4057qib7 6413 6 assess assess VB cord-005453-4057qib7 6413 7 the the DT cord-005453-4057qib7 6413 8 efficacy efficacy NN cord-005453-4057qib7 6413 9 of of IN cord-005453-4057qib7 6413 10 MaaT013 MaaT013 NNP cord-005453-4057qib7 6413 11 by by IN cord-005453-4057qib7 6413 12 evaluating evaluate VBG cord-005453-4057qib7 6413 13 complete complete JJ cord-005453-4057qib7 6413 14 response response NN cord-005453-4057qib7 6413 15 ( ( -LRB- cord-005453-4057qib7 6413 16 CR cr NN cord-005453-4057qib7 6413 17 , , , cord-005453-4057qib7 6413 18 according accord VBG cord-005453-4057qib7 6413 19 to to IN cord-005453-4057qib7 6413 20 modified modify VBN cord-005453-4057qib7 6413 21 Glucksberg Glucksberg NNP cord-005453-4057qib7 6413 22 criteria criterion NNS cord-005453-4057qib7 6413 23 ) ) -RRB- cord-005453-4057qib7 6413 24 and and CC cord-005453-4057qib7 6413 25 Very very RB cord-005453-4057qib7 6413 26 Good Good NNP cord-005453-4057qib7 6413 27 Partial partial JJ cord-005453-4057qib7 6413 28 Response response NN cord-005453-4057qib7 6413 29 ( ( -LRB- cord-005453-4057qib7 6413 30 VGPR VGPR NNP cord-005453-4057qib7 6413 31 , , , cord-005453-4057qib7 6413 32 defined define VBN cord-005453-4057qib7 6413 33 by by IN cord-005453-4057qib7 6413 34 Martin Martin NNP cord-005453-4057qib7 6413 35 et et NNP cord-005453-4057qib7 6413 36 al al NNP cord-005453-4057qib7 6413 37 . . . cord-005453-4057qib7 6414 1 , , , cord-005453-4057qib7 6414 2 BBMT BBMT NNP cord-005453-4057qib7 6414 3 , , , cord-005453-4057qib7 6414 4 2009 2009 CD cord-005453-4057qib7 6414 5 ) ) -RRB- cord-005453-4057qib7 6415 1 28 28 CD cord-005453-4057qib7 6415 2 days day NNS cord-005453-4057qib7 6415 3 post post NN cord-005453-4057qib7 6415 4 - - NN cord-005453-4057qib7 6415 5 inclusion inclusion JJ cord-005453-4057qib7 6415 6 ( ( -LRB- cord-005453-4057qib7 6415 7 Primary primary JJ cord-005453-4057qib7 6415 8 follow follow NN cord-005453-4057qib7 6415 9 - - HYPH cord-005453-4057qib7 6415 10 up up NN cord-005453-4057qib7 6415 11 ) ) -RRB- cord-005453-4057qib7 6415 12 . . . cord-005453-4057qib7 6416 1 Secondary secondary JJ cord-005453-4057qib7 6416 2 objectives objective NNS cord-005453-4057qib7 6416 3 include include VBP cord-005453-4057qib7 6416 4 FMT fmt NN cord-005453-4057qib7 6416 5 safety safety NN cord-005453-4057qib7 6416 6 assessment assessment NN cord-005453-4057qib7 6416 7 and and CC cord-005453-4057qib7 6416 8 evaluation evaluation NN cord-005453-4057qib7 6416 9 of of IN cord-005453-4057qib7 6416 10 FMT fmt NN cord-005453-4057qib7 6416 11 impact impact NN cord-005453-4057qib7 6416 12 on on IN cord-005453-4057qib7 6416 13 several several JJ cord-005453-4057qib7 6416 14 endpoints endpoint NNS cord-005453-4057qib7 6416 15 , , , cord-005453-4057qib7 6416 16 such such JJ cord-005453-4057qib7 6416 17 as as IN cord-005453-4057qib7 6416 18 overall overall JJ cord-005453-4057qib7 6416 19 , , , cord-005453-4057qib7 6416 20 relapsefree relapsefree JJ cord-005453-4057qib7 6416 21 or or CC cord-005453-4057qib7 6416 22 GVHD GVHD NNP cord-005453-4057qib7 6416 23 - - HYPH cord-005453-4057qib7 6416 24 free free JJ cord-005453-4057qib7 6416 25 survival survival NN cord-005453-4057qib7 6416 26 and and CC cord-005453-4057qib7 6416 27 chronic chronic JJ cord-005453-4057qib7 6416 28 GVHD GVHD NNP cord-005453-4057qib7 6416 29 evaluation evaluation NN cord-005453-4057qib7 6416 30 , , , cord-005453-4057qib7 6416 31 as as RB cord-005453-4057qib7 6416 32 well well RB cord-005453-4057qib7 6416 33 as as IN cord-005453-4057qib7 6416 34 multi multi JJ cord-005453-4057qib7 6416 35 - - JJ cord-005453-4057qib7 6416 36 drug drug JJ cord-005453-4057qib7 6416 37 resistant resistant JJ cord-005453-4057qib7 6416 38 bacteria bacteria NNS cord-005453-4057qib7 6416 39 carriage carriage NN cord-005453-4057qib7 6416 40 . . . cord-005453-4057qib7 6417 1 Patients patient NNS cord-005453-4057qib7 6417 2 will will MD cord-005453-4057qib7 6417 3 be be VB cord-005453-4057qib7 6417 4 followed follow VBN cord-005453-4057qib7 6417 5 - - HYPH cord-005453-4057qib7 6417 6 up up RP cord-005453-4057qib7 6417 7 until1 until1 NN cord-005453-4057qib7 6417 8 year year NN cord-005453-4057qib7 6417 9 after after IN cord-005453-4057qib7 6417 10 inclusion inclusion NN cord-005453-4057qib7 6417 11 . . . cord-005453-4057qib7 6418 1 Overall overall RB cord-005453-4057qib7 6418 2 , , , cord-005453-4057qib7 6418 3 32 32 CD cord-005453-4057qib7 6418 4 patients patient NNS cord-005453-4057qib7 6418 5 are be VBP cord-005453-4057qib7 6418 6 planned plan VBN cord-005453-4057qib7 6418 7 to to TO cord-005453-4057qib7 6418 8 be be VB cord-005453-4057qib7 6418 9 enrolled enrol VBN cord-005453-4057qib7 6418 10 and and CC cord-005453-4057qib7 6418 11 treated treat VBN cord-005453-4057qib7 6418 12 , , , cord-005453-4057qib7 6418 13 to to TO cord-005453-4057qib7 6418 14 assess assess VB cord-005453-4057qib7 6418 15 overall overall JJ cord-005453-4057qib7 6418 16 response response NN cord-005453-4057qib7 6418 17 rates rate NNS cord-005453-4057qib7 6418 18 and and CC cord-005453-4057qib7 6418 19 MaaT013 MaaT013 NNP cord-005453-4057qib7 6418 20 's 's POS cord-005453-4057qib7 6418 21 safety safety NN cord-005453-4057qib7 6418 22 profile profile NN cord-005453-4057qib7 6418 23 . . . cord-005453-4057qib7 6419 1 Results result NNS cord-005453-4057qib7 6419 2 Background Background NNP cord-005453-4057qib7 6419 3 : : : cord-005453-4057qib7 6419 4 Anti anti JJ cord-005453-4057qib7 6419 5 - - JJ cord-005453-4057qib7 6419 6 programmed programmed JJ cord-005453-4057qib7 6419 7 cell cell NN cord-005453-4057qib7 6419 8 death death NN cord-005453-4057qib7 6419 9 protein protein NN cord-005453-4057qib7 6419 10 1 1 CD cord-005453-4057qib7 6420 1 ( ( -LRB- cord-005453-4057qib7 6420 2 PD1 pd1 NN cord-005453-4057qib7 6420 3 ) ) -RRB- cord-005453-4057qib7 6420 4 monoclonal monoclonal JJ cord-005453-4057qib7 6420 5 antibodies antibody NNS cord-005453-4057qib7 6420 6 can can MD cord-005453-4057qib7 6420 7 be be VB cord-005453-4057qib7 6420 8 used use VBN cord-005453-4057qib7 6420 9 as as IN cord-005453-4057qib7 6420 10 " " `` cord-005453-4057qib7 6420 11 bridge bridge NN cord-005453-4057qib7 6420 12 to to IN cord-005453-4057qib7 6420 13 " " '' cord-005453-4057qib7 6420 14 a a DT cord-005453-4057qib7 6420 15 subsequent subsequent JJ cord-005453-4057qib7 6420 16 allogeneic allogeneic NN cord-005453-4057qib7 6420 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 6420 18 stem stem NN cord-005453-4057qib7 6420 19 cell cell NN cord-005453-4057qib7 6420 20 transplantation transplantation NN cord-005453-4057qib7 6420 21 ( ( -LRB- cord-005453-4057qib7 6420 22 HSCT HSCT NNP cord-005453-4057qib7 6420 23 ) ) -RRB- cord-005453-4057qib7 6420 24 in in IN cord-005453-4057qib7 6420 25 patients patient NNS cord-005453-4057qib7 6420 26 with with IN cord-005453-4057qib7 6420 27 relapsed relapse VBN cord-005453-4057qib7 6420 28 / / SYM cord-005453-4057qib7 6420 29 refractory refractory JJ cord-005453-4057qib7 6420 30 Hodgkin´s hodgkin´ NNS cord-005453-4057qib7 6421 1 Lymphoma Lymphoma NNP cord-005453-4057qib7 6421 2 ( ( -LRB- cord-005453-4057qib7 6421 3 HL HL NNP cord-005453-4057qib7 6421 4 ) ) -RRB- cord-005453-4057qib7 6421 5 . . . cord-005453-4057qib7 6422 1 This this DT cord-005453-4057qib7 6422 2 strategy strategy NN cord-005453-4057qib7 6422 3 has have VBZ cord-005453-4057qib7 6422 4 been be VBN cord-005453-4057qib7 6422 5 reported report VBN cord-005453-4057qib7 6422 6 to to TO cord-005453-4057qib7 6422 7 be be VB cord-005453-4057qib7 6422 8 effective effective JJ cord-005453-4057qib7 6422 9 , , , cord-005453-4057qib7 6422 10 but but CC cord-005453-4057qib7 6422 11 a a DT cord-005453-4057qib7 6422 12 frequent frequent JJ cord-005453-4057qib7 6422 13 onset onset NN cord-005453-4057qib7 6422 14 of of IN cord-005453-4057qib7 6422 15 steroid steroid JJ cord-005453-4057qib7 6422 16 - - HYPH cord-005453-4057qib7 6422 17 refractory refractory JJ cord-005453-4057qib7 6422 18 Graft graft NN cord-005453-4057qib7 6422 19 versus versus IN cord-005453-4057qib7 6422 20 Host Host NNP cord-005453-4057qib7 6422 21 Disease Disease NNP cord-005453-4057qib7 6422 22 ( ( -LRB- cord-005453-4057qib7 6422 23 GVHD GVHD NNP cord-005453-4057qib7 6422 24 ) ) -RRB- cord-005453-4057qib7 6422 25 was be VBD cord-005453-4057qib7 6422 26 also also RB cord-005453-4057qib7 6422 27 reported report VBN cord-005453-4057qib7 6422 28 . . . cord-005453-4057qib7 6423 1 We -PRON- PRP cord-005453-4057qib7 6423 2 report report VBP cord-005453-4057qib7 6423 3 3 3 CD cord-005453-4057qib7 6423 4 clinical clinical JJ cord-005453-4057qib7 6423 5 cases case NNS cord-005453-4057qib7 6423 6 of of IN cord-005453-4057qib7 6423 7 patients patient NNS cord-005453-4057qib7 6423 8 affected affect VBN cord-005453-4057qib7 6423 9 by by IN cord-005453-4057qib7 6423 10 HL HL NNP cord-005453-4057qib7 6423 11 undergoing undergo VBG cord-005453-4057qib7 6423 12 allogeneic allogeneic IN cord-005453-4057qib7 6423 13 HSCT HSCT NNP cord-005453-4057qib7 6423 14 after after IN cord-005453-4057qib7 6423 15 having have VBG cord-005453-4057qib7 6423 16 been be VBN cord-005453-4057qib7 6423 17 treated treat VBN cord-005453-4057qib7 6423 18 with with IN cord-005453-4057qib7 6423 19 Nivolumab Nivolumab NNP cord-005453-4057qib7 6423 20 . . . cord-005453-4057qib7 6424 1 Methods method NNS cord-005453-4057qib7 6424 2 : : : cord-005453-4057qib7 6425 1 The the DT cord-005453-4057qib7 6425 2 3 3 CD cord-005453-4057qib7 6425 3 patients patient NNS cord-005453-4057qib7 6425 4 of of IN cord-005453-4057qib7 6425 5 48 48 CD cord-005453-4057qib7 6425 6 , , , cord-005453-4057qib7 6425 7 18 18 CD cord-005453-4057qib7 6425 8 and and CC cord-005453-4057qib7 6425 9 42 42 CD cord-005453-4057qib7 6425 10 years year NNS cord-005453-4057qib7 6425 11 respectively respectively RB cord-005453-4057qib7 6425 12 had have VBD cord-005453-4057qib7 6425 13 advanced advance VBN cord-005453-4057qib7 6425 14 HL HL NNP cord-005453-4057qib7 6425 15 and and CC cord-005453-4057qib7 6425 16 had have VBD cord-005453-4057qib7 6425 17 relapsed relapse VBN cord-005453-4057qib7 6425 18 after after IN cord-005453-4057qib7 6425 19 a a DT cord-005453-4057qib7 6425 20 previous previous JJ cord-005453-4057qib7 6425 21 autologous autologous NN cord-005453-4057qib7 6425 22 ( ( -LRB- cord-005453-4057qib7 6425 23 2 2 CD cord-005453-4057qib7 6425 24 ) ) -RRB- cord-005453-4057qib7 6425 25 or or CC cord-005453-4057qib7 6426 1 allogeneic allogeneic NNP cord-005453-4057qib7 6426 2 ( ( -LRB- cord-005453-4057qib7 6426 3 1 1 CD cord-005453-4057qib7 6426 4 ) ) -RRB- cord-005453-4057qib7 6426 5 HSCT HSCT NNP cord-005453-4057qib7 6426 6 . . . cord-005453-4057qib7 6427 1 They -PRON- PRP cord-005453-4057qib7 6427 2 underwent undergo VBD cord-005453-4057qib7 6427 3 a a DT cord-005453-4057qib7 6427 4 rescue rescue NN cord-005453-4057qib7 6427 5 therapy therapy NN cord-005453-4057qib7 6427 6 with with IN cord-005453-4057qib7 6427 7 18 18 CD cord-005453-4057qib7 6427 8 , , , cord-005453-4057qib7 6427 9 12 12 CD cord-005453-4057qib7 6427 10 , , , cord-005453-4057qib7 6427 11 16 16 CD cord-005453-4057qib7 6427 12 Nivolumab Nivolumab NNP cord-005453-4057qib7 6427 13 cycles cycle NNS cord-005453-4057qib7 6427 14 respectively respectively RB cord-005453-4057qib7 6427 15 , , , cord-005453-4057qib7 6427 16 depending depend VBG cord-005453-4057qib7 6427 17 on on IN cord-005453-4057qib7 6427 18 the the DT cord-005453-4057qib7 6427 19 time time NN cord-005453-4057qib7 6427 20 of of IN cord-005453-4057qib7 6427 21 partial partial JJ cord-005453-4057qib7 6427 22 response response NN cord-005453-4057qib7 6427 23 achievement achievement NN cord-005453-4057qib7 6427 24 and and CC cord-005453-4057qib7 6427 25 the the DT cord-005453-4057qib7 6427 26 availability availability NN cord-005453-4057qib7 6427 27 of of IN cord-005453-4057qib7 6427 28 a a DT cord-005453-4057qib7 6427 29 donor donor NN cord-005453-4057qib7 6427 30 . . . cord-005453-4057qib7 6428 1 Two two CD cord-005453-4057qib7 6428 2 patients patient NNS cord-005453-4057qib7 6428 3 received receive VBD cord-005453-4057qib7 6428 4 a a DT cord-005453-4057qib7 6428 5 thiotepa thiotepa JJ cord-005453-4057qib7 6428 6 - - HYPH cord-005453-4057qib7 6428 7 fludarabinecyclophosphamide fludarabinecyclophosphamide NN cord-005453-4057qib7 6428 8 conditioning conditioning NN cord-005453-4057qib7 6428 9 , , , cord-005453-4057qib7 6428 10 ATG ATG NNP cord-005453-4057qib7 6428 11 - - HYPH cord-005453-4057qib7 6428 12 based base VBN cord-005453-4057qib7 6428 13 prophylaxis prophylaxis NN cord-005453-4057qib7 6428 14 and and CC cord-005453-4057qib7 6428 15 PB PB NNP cord-005453-4057qib7 6428 16 cells cell NNS cord-005453-4057qib7 6428 17 from from IN cord-005453-4057qib7 6428 18 unrelated unrelated JJ cord-005453-4057qib7 6428 19 donors donor NNS cord-005453-4057qib7 6428 20 . . . cord-005453-4057qib7 6429 1 The the DT cord-005453-4057qib7 6429 2 third third JJ cord-005453-4057qib7 6429 3 patient patient NN cord-005453-4057qib7 6429 4 received receive VBD cord-005453-4057qib7 6429 5 BM BM NNP cord-005453-4057qib7 6429 6 cells cell NNS cord-005453-4057qib7 6429 7 from from IN cord-005453-4057qib7 6429 8 an an DT cord-005453-4057qib7 6429 9 haploidentical haploidentical JJ cord-005453-4057qib7 6429 10 donor donor NN cord-005453-4057qib7 6429 11 using use VBG cord-005453-4057qib7 6429 12 the the DT cord-005453-4057qib7 6429 13 " " `` cord-005453-4057qib7 6429 14 Baltimora Baltimora NNP cord-005453-4057qib7 6429 15 " " '' cord-005453-4057qib7 6429 16 nonmieloablative nonmieloablative JJ cord-005453-4057qib7 6429 17 platform platform NN cord-005453-4057qib7 6429 18 . . . cord-005453-4057qib7 6430 1 Results result NNS cord-005453-4057qib7 6430 2 : : : cord-005453-4057qib7 6431 1 At at IN cord-005453-4057qib7 6431 2 a a DT cord-005453-4057qib7 6431 3 follow follow NN cord-005453-4057qib7 6431 4 - - HYPH cord-005453-4057qib7 6431 5 up up NN cord-005453-4057qib7 6431 6 of of IN cord-005453-4057qib7 6431 7 11 11 CD cord-005453-4057qib7 6431 8 , , , cord-005453-4057qib7 6431 9 12 12 CD cord-005453-4057qib7 6431 10 , , , cord-005453-4057qib7 6431 11 15 15 CD cord-005453-4057qib7 6431 12 months month NNS cord-005453-4057qib7 6431 13 after after IN cord-005453-4057qib7 6431 14 HSCT HSCT NNP cord-005453-4057qib7 6431 15 , , , cord-005453-4057qib7 6431 16 respectively respectively RB cord-005453-4057qib7 6431 17 , , , cord-005453-4057qib7 6431 18 all all DT cord-005453-4057qib7 6431 19 patients patient NNS cord-005453-4057qib7 6431 20 achieved achieve VBN cord-005453-4057qib7 6431 21 and and CC cord-005453-4057qib7 6431 22 maintained maintain VBD cord-005453-4057qib7 6431 23 a a DT cord-005453-4057qib7 6431 24 complete complete JJ cord-005453-4057qib7 6431 25 remission remission NN cord-005453-4057qib7 6431 26 by by IN cord-005453-4057qib7 6431 27 PET PET NNP cord-005453-4057qib7 6431 28 - - HYPH cord-005453-4057qib7 6431 29 CT CT NNP cord-005453-4057qib7 6431 30 scans scan NNS cord-005453-4057qib7 6431 31 . . . cord-005453-4057qib7 6432 1 All all PDT cord-005453-4057qib7 6432 2 the the DT cord-005453-4057qib7 6432 3 3 3 CD cord-005453-4057qib7 6432 4 patients patient NNS cord-005453-4057qib7 6432 5 developed develop VBD cord-005453-4057qib7 6432 6 acute acute JJ cord-005453-4057qib7 6432 7 GVHD GVHD NNP cord-005453-4057qib7 6432 8 on on IN cord-005453-4057qib7 6432 9 day day NN cord-005453-4057qib7 6432 10 +32 +32 NNP cord-005453-4057qib7 6432 11 , , , cord-005453-4057qib7 6432 12 +54 +54 NNP cord-005453-4057qib7 6432 13 and and CC cord-005453-4057qib7 6432 14 +107 +107 NNP cord-005453-4057qib7 6432 15 , , , cord-005453-4057qib7 6432 16 respectively respectively RB cord-005453-4057qib7 6432 17 . . . cord-005453-4057qib7 6433 1 Patient patient NN cord-005453-4057qib7 6433 2 1 1 CD cord-005453-4057qib7 6433 3 progressed progress VBD cord-005453-4057qib7 6433 4 to to IN cord-005453-4057qib7 6433 5 grade grade NN cord-005453-4057qib7 6433 6 IV IV NNP cord-005453-4057qib7 6433 7 acute acute JJ cord-005453-4057qib7 6433 8 GVHD GVHD NNP cord-005453-4057qib7 6433 9 with with IN cord-005453-4057qib7 6433 10 hepatic hepatic JJ cord-005453-4057qib7 6433 11 and and CC cord-005453-4057qib7 6433 12 intestinal intestinal JJ cord-005453-4057qib7 6433 13 involvement involvement NN cord-005453-4057qib7 6433 14 unresponsive unresponsive JJ cord-005453-4057qib7 6433 15 to to IN cord-005453-4057qib7 6433 16 first first JJ cord-005453-4057qib7 6433 17 line line NN cord-005453-4057qib7 6433 18 2 2 CD cord-005453-4057qib7 6433 19 mg mg NNP cord-005453-4057qib7 6433 20 / / SYM cord-005453-4057qib7 6433 21 kg kg NNP cord-005453-4057qib7 6433 22 steroid steroid NN cord-005453-4057qib7 6433 23 therapy therapy NN cord-005453-4057qib7 6433 24 and and CC cord-005453-4057qib7 6433 25 second second JJ cord-005453-4057qib7 6433 26 line line NN cord-005453-4057qib7 6433 27 etanercept etanercept NN cord-005453-4057qib7 6433 28 plus plus CC cord-005453-4057qib7 6433 29 extracorporeal extracorporeal JJ cord-005453-4057qib7 6433 30 photopheresis photopheresis NN cord-005453-4057qib7 6433 31 ( ( -LRB- cord-005453-4057qib7 6433 32 ECP ECP NNP cord-005453-4057qib7 6433 33 ) ) -RRB- cord-005453-4057qib7 6433 34 . . . cord-005453-4057qib7 6434 1 Third third JJ cord-005453-4057qib7 6434 2 line line NN cord-005453-4057qib7 6434 3 therapy therapy NN cord-005453-4057qib7 6434 4 with with IN cord-005453-4057qib7 6434 5 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6434 6 partially partially RB cord-005453-4057qib7 6434 7 controlled control VBD cord-005453-4057qib7 6434 8 the the DT cord-005453-4057qib7 6434 9 GVHD GVHD NNP cord-005453-4057qib7 6434 10 . . . cord-005453-4057qib7 6435 1 GVHD GVHD NNP cord-005453-4057qib7 6435 2 onset onset NN cord-005453-4057qib7 6435 3 in in IN cord-005453-4057qib7 6435 4 patients patient NNS cord-005453-4057qib7 6435 5 2 2 CD cord-005453-4057qib7 6435 6 and and CC cord-005453-4057qib7 6435 7 3 3 CD cord-005453-4057qib7 6435 8 was be VBD cord-005453-4057qib7 6435 9 preceeded preceede VBN cord-005453-4057qib7 6435 10 by by IN cord-005453-4057qib7 6435 11 a a DT cord-005453-4057qib7 6435 12 prolonged prolonged JJ cord-005453-4057qib7 6435 13 fever fever NN cord-005453-4057qib7 6435 14 without without IN cord-005453-4057qib7 6435 15 microbiological microbiological JJ cord-005453-4057qib7 6435 16 findings finding NNS cord-005453-4057qib7 6435 17 . . . cord-005453-4057qib7 6436 1 Patient patient NN cord-005453-4057qib7 6436 2 2 2 CD cord-005453-4057qib7 6436 3 developed develop VBD cord-005453-4057qib7 6436 4 hepatic hepatic JJ cord-005453-4057qib7 6436 5 grade grade NN cord-005453-4057qib7 6436 6 II II NNP cord-005453-4057qib7 6436 7 GVHD GVHD NNP cord-005453-4057qib7 6436 8 with with IN cord-005453-4057qib7 6436 9 high high JJ cord-005453-4057qib7 6436 10 transaminase transaminase NN cord-005453-4057qib7 6436 11 levels level NNS cord-005453-4057qib7 6436 12 , , , cord-005453-4057qib7 6436 13 initially initially RB cord-005453-4057qib7 6436 14 responsive responsive JJ cord-005453-4057qib7 6436 15 to to IN cord-005453-4057qib7 6436 16 steroid steroid NN cord-005453-4057qib7 6436 17 therapy therapy NN cord-005453-4057qib7 6436 18 , , , cord-005453-4057qib7 6436 19 then then RB cord-005453-4057qib7 6436 20 it -PRON- PRP cord-005453-4057qib7 6436 21 progressed progress VBD cord-005453-4057qib7 6436 22 to to TO cord-005453-4057qib7 6436 23 gut gut VB cord-005453-4057qib7 6436 24 requiring require VBG cord-005453-4057qib7 6436 25 second second JJ cord-005453-4057qib7 6436 26 line line NN cord-005453-4057qib7 6436 27 therapy therapy NN cord-005453-4057qib7 6436 28 with with IN cord-005453-4057qib7 6436 29 etanercept etanercept NNP cord-005453-4057qib7 6436 30 . . . cord-005453-4057qib7 6437 1 Patient patient NN cord-005453-4057qib7 6437 2 3 3 CD cord-005453-4057qib7 6437 3 progressed progress VBD cord-005453-4057qib7 6437 4 to to IN cord-005453-4057qib7 6437 5 severe severe JJ cord-005453-4057qib7 6437 6 chronic chronic JJ cord-005453-4057qib7 6437 7 GVHD GVHD NNP cord-005453-4057qib7 6437 8 with with IN cord-005453-4057qib7 6437 9 skin skin NN cord-005453-4057qib7 6437 10 involvement involvement NN cord-005453-4057qib7 6437 11 and and CC cord-005453-4057qib7 6437 12 resulted result VBD cord-005453-4057qib7 6437 13 unresponsive unresponsive JJ cord-005453-4057qib7 6437 14 to to IN cord-005453-4057qib7 6437 15 steroids steroid NNS cord-005453-4057qib7 6437 16 and and CC cord-005453-4057qib7 6437 17 ECP ECP NNP cord-005453-4057qib7 6438 1 and and CC cord-005453-4057qib7 6438 2 it -PRON- PRP cord-005453-4057qib7 6438 3 was be VBD cord-005453-4057qib7 6438 4 partially partially RB cord-005453-4057qib7 6438 5 controlled control VBN cord-005453-4057qib7 6438 6 by by IN cord-005453-4057qib7 6438 7 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 6438 8 . . . cord-005453-4057qib7 6439 1 Immune immune JJ cord-005453-4057qib7 6439 2 reconstitution reconstitution NN cord-005453-4057qib7 6439 3 was be VBD cord-005453-4057qib7 6439 4 delayed delay VBN cord-005453-4057qib7 6439 5 in in IN cord-005453-4057qib7 6439 6 all all DT cord-005453-4057qib7 6439 7 3 3 CD cord-005453-4057qib7 6439 8 patients patient NNS cord-005453-4057qib7 6439 9 : : : cord-005453-4057qib7 6439 10 at at IN cord-005453-4057qib7 6439 11 6 6 CD cord-005453-4057qib7 6439 12 months month NNS cord-005453-4057qib7 6439 13 post post NN cord-005453-4057qib7 6439 14 transplantation transplantation NN cord-005453-4057qib7 6439 15 CD3 cd3 NN cord-005453-4057qib7 6439 16 levels level NNS cord-005453-4057qib7 6439 17 were be VBD cord-005453-4057qib7 6439 18 80 80 CD cord-005453-4057qib7 6440 1 /μL /μL NFP cord-005453-4057qib7 6440 2 , , , cord-005453-4057qib7 6441 1 17/ 17/ CD cord-005453-4057qib7 6441 2 μL μl ADD cord-005453-4057qib7 6441 3 and and CC cord-005453-4057qib7 6442 1 127 127 CD cord-005453-4057qib7 6442 2 / / SYM cord-005453-4057qib7 6442 3 μL μL NNP cord-005453-4057qib7 6442 4 and and CC cord-005453-4057qib7 6442 5 CD4 CD4 NNP cord-005453-4057qib7 6442 6 levels level NNS cord-005453-4057qib7 6442 7 were be VBD cord-005453-4057qib7 6442 8 36 36 CD cord-005453-4057qib7 6442 9 / / SYM cord-005453-4057qib7 6442 10 μL μL NNP cord-005453-4057qib7 6442 11 , , , cord-005453-4057qib7 6442 12 16 16 CD cord-005453-4057qib7 6442 13 / / SYM cord-005453-4057qib7 6442 14 μL μl NN cord-005453-4057qib7 6442 15 and and CC cord-005453-4057qib7 6442 16 65/ 65/ CD cord-005453-4057qib7 6442 17 μL μl NN cord-005453-4057qib7 6442 18 respectively respectively RB cord-005453-4057qib7 6442 19 . . . cord-005453-4057qib7 6443 1 Only only RB cord-005453-4057qib7 6443 2 patient patient JJ cord-005453-4057qib7 6443 3 2 2 CD cord-005453-4057qib7 6443 4 , , , cord-005453-4057qib7 6443 5 that that WDT cord-005453-4057qib7 6443 6 underwent undergo VBD cord-005453-4057qib7 6443 7 haploidentical haploidentical JJ cord-005453-4057qib7 6443 8 transplant transplant NN cord-005453-4057qib7 6443 9 and and CC cord-005453-4057qib7 6443 10 received receive VBD cord-005453-4057qib7 6443 11 post post JJ cord-005453-4057qib7 6443 12 - - JJ cord-005453-4057qib7 6443 13 trasplant trasplant JJ cord-005453-4057qib7 6443 14 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 6443 15 ( ( -LRB- cord-005453-4057qib7 6443 16 PT PT NNP cord-005453-4057qib7 6443 17 - - HYPH cord-005453-4057qib7 6443 18 Cy Cy NNP cord-005453-4057qib7 6443 19 ) ) -RRB- cord-005453-4057qib7 6443 20 , , , cord-005453-4057qib7 6443 21 is be VBZ cord-005453-4057qib7 6443 22 off off IN cord-005453-4057qib7 6443 23 of of IN cord-005453-4057qib7 6443 24 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6443 25 treatment treatment NN cord-005453-4057qib7 6443 26 at at IN cord-005453-4057qib7 6443 27 11 11 CD cord-005453-4057qib7 6443 28 months month NNS cord-005453-4057qib7 6443 29 after after IN cord-005453-4057qib7 6443 30 HSCT HSCT NNP cord-005453-4057qib7 6443 31 , , , cord-005453-4057qib7 6443 32 without without IN cord-005453-4057qib7 6443 33 evidence evidence NN cord-005453-4057qib7 6443 34 of of IN cord-005453-4057qib7 6443 35 GVHD GVHD NNP cord-005453-4057qib7 6443 36 and and CC cord-005453-4057qib7 6443 37 no no DT cord-005453-4057qib7 6443 38 history history NN cord-005453-4057qib7 6443 39 of of IN cord-005453-4057qib7 6443 40 infections infection NNS cord-005453-4057qib7 6443 41 . . . cord-005453-4057qib7 6444 1 Out out IN cord-005453-4057qib7 6444 2 of of IN cord-005453-4057qib7 6444 3 the the DT cord-005453-4057qib7 6444 4 2 2 CD cord-005453-4057qib7 6444 5 patients patient NNS cord-005453-4057qib7 6444 6 receiving receive VBG cord-005453-4057qib7 6444 7 PBSC PBSC NNS cord-005453-4057qib7 6444 8 from from IN cord-005453-4057qib7 6444 9 unrelated unrelated JJ cord-005453-4057qib7 6444 10 donors donor NNS cord-005453-4057qib7 6444 11 and and CC cord-005453-4057qib7 6444 12 ATG ATG NNP cord-005453-4057qib7 6444 13 prophylaxis prophylaxis NN cord-005453-4057qib7 6444 14 , , , cord-005453-4057qib7 6444 15 patient patient NN cord-005453-4057qib7 6444 16 1 1 CD cord-005453-4057qib7 6444 17 developed develop VBD cord-005453-4057qib7 6444 18 a a DT cord-005453-4057qib7 6444 19 disseminated disseminate VBN cord-005453-4057qib7 6444 20 fusariosis fusariosis NN cord-005453-4057qib7 6444 21 on on IN cord-005453-4057qib7 6444 22 day day NN cord-005453-4057qib7 6444 23 + + SYM cord-005453-4057qib7 6444 24 180 180 CD cord-005453-4057qib7 6444 25 and and CC cord-005453-4057qib7 6444 26 died die VBD cord-005453-4057qib7 6444 27 of of IN cord-005453-4057qib7 6444 28 CNS CNS NNP cord-005453-4057qib7 6444 29 fusarium fusarium NN cord-005453-4057qib7 6444 30 localization localization NN cord-005453-4057qib7 6444 31 1 1 CD cord-005453-4057qib7 6444 32 year year NN cord-005453-4057qib7 6444 33 after after IN cord-005453-4057qib7 6444 34 HSCT HSCT NNP cord-005453-4057qib7 6444 35 , , , cord-005453-4057qib7 6444 36 despite despite IN cord-005453-4057qib7 6444 37 targeted target VBN cord-005453-4057qib7 6444 38 antifungal antifungal NN cord-005453-4057qib7 6444 39 therapy therapy NN cord-005453-4057qib7 6444 40 . . . cord-005453-4057qib7 6445 1 Patient Patient NNP cord-005453-4057qib7 6445 2 3 3 CD cord-005453-4057qib7 6445 3 had have VBD cord-005453-4057qib7 6445 4 pulmonary pulmonary JJ cord-005453-4057qib7 6445 5 aspergillosis aspergillosis NN cord-005453-4057qib7 6445 6 , , , cord-005453-4057qib7 6445 7 sepsis sepsis NN cord-005453-4057qib7 6445 8 by by IN cord-005453-4057qib7 6445 9 multidrug multidrug NN cord-005453-4057qib7 6445 10 resistant resistant JJ cord-005453-4057qib7 6445 11 Psuedomonas Psuedomonas NNP cord-005453-4057qib7 6445 12 Aeruginosa Aeruginosa NNP cord-005453-4057qib7 6445 13 and and CC cord-005453-4057qib7 6445 14 otomastoiditis otomastoiditis NN cord-005453-4057qib7 6445 15 : : : cord-005453-4057qib7 6445 16 at at IN cord-005453-4057qib7 6445 17 +15 +15 CD cord-005453-4057qib7 6445 18 months month NNS cord-005453-4057qib7 6445 19 after after IN cord-005453-4057qib7 6445 20 HSCT HSCT NNP cord-005453-4057qib7 6445 21 , , , cord-005453-4057qib7 6445 22 he -PRON- PRP cord-005453-4057qib7 6445 23 is be VBZ cord-005453-4057qib7 6445 24 on on IN cord-005453-4057qib7 6445 25 ruxolitinib ruxolitinib JJ cord-005453-4057qib7 6445 26 treatment treatment NN cord-005453-4057qib7 6445 27 with with IN cord-005453-4057qib7 6445 28 skin skin NN cord-005453-4057qib7 6445 29 clinical clinical JJ cord-005453-4057qib7 6445 30 partial partial JJ cord-005453-4057qib7 6445 31 response response NN cord-005453-4057qib7 6445 32 . . . cord-005453-4057qib7 6446 1 Conclusions conclusion NNS cord-005453-4057qib7 6446 2 : : : cord-005453-4057qib7 6447 1 This this DT cord-005453-4057qib7 6447 2 case case NN cord-005453-4057qib7 6447 3 series series NN cord-005453-4057qib7 6447 4 confirms confirm VBZ cord-005453-4057qib7 6447 5 that that IN cord-005453-4057qib7 6447 6 Nivolumab Nivolumab NNP cord-005453-4057qib7 6447 7 as as IN cord-005453-4057qib7 6447 8 " " `` cord-005453-4057qib7 6447 9 bridge bridge NN cord-005453-4057qib7 6447 10 to to IN cord-005453-4057qib7 6447 11 transplant transplant NN cord-005453-4057qib7 6447 12 " " `` cord-005453-4057qib7 6447 13 is be VBZ cord-005453-4057qib7 6447 14 effective effective JJ cord-005453-4057qib7 6447 15 in in IN cord-005453-4057qib7 6447 16 appropriately appropriately RB cord-005453-4057qib7 6447 17 selected select VBN cord-005453-4057qib7 6447 18 patients patient NNS cord-005453-4057qib7 6447 19 . . . cord-005453-4057qib7 6448 1 However however RB cord-005453-4057qib7 6448 2 , , , cord-005453-4057qib7 6448 3 risk risk NN cord-005453-4057qib7 6448 4 of of IN cord-005453-4057qib7 6448 5 acute acute JJ cord-005453-4057qib7 6448 6 GVHD GVHD NNP cord-005453-4057qib7 6448 7 and and CC cord-005453-4057qib7 6448 8 delayed delay VBN cord-005453-4057qib7 6448 9 immune immune JJ cord-005453-4057qib7 6448 10 reconstitution reconstitution NN cord-005453-4057qib7 6448 11 may may MD cord-005453-4057qib7 6448 12 require require VB cord-005453-4057qib7 6448 13 a a DT cord-005453-4057qib7 6448 14 careful careful JJ cord-005453-4057qib7 6448 15 consideration consideration NN cord-005453-4057qib7 6448 16 at at IN cord-005453-4057qib7 6448 17 the the DT cord-005453-4057qib7 6448 18 moment moment NN cord-005453-4057qib7 6448 19 of of IN cord-005453-4057qib7 6448 20 planning plan VBG cord-005453-4057qib7 6448 21 the the DT cord-005453-4057qib7 6448 22 transplant transplant NN cord-005453-4057qib7 6448 23 . . . cord-005453-4057qib7 6449 1 A a DT cord-005453-4057qib7 6449 2 possible possible JJ cord-005453-4057qib7 6449 3 advantage advantage NN cord-005453-4057qib7 6449 4 of of IN cord-005453-4057qib7 6449 5 PT PT NNP cord-005453-4057qib7 6449 6 - - HYPH cord-005453-4057qib7 6449 7 Cy Cy NNP cord-005453-4057qib7 6449 8 GVHD GVHD NNP cord-005453-4057qib7 6449 9 platform platform NN cord-005453-4057qib7 6449 10 and and CC cord-005453-4057qib7 6449 11 haploidentical haploidentical JJ cord-005453-4057qib7 6449 12 donors donor NNS cord-005453-4057qib7 6449 13 should should MD cord-005453-4057qib7 6449 14 be be VB cord-005453-4057qib7 6449 15 addressed address VBN cord-005453-4057qib7 6449 16 in in IN cord-005453-4057qib7 6449 17 larger large JJR cord-005453-4057qib7 6449 18 studies study NNS cord-005453-4057qib7 6449 19 . . . cord-005453-4057qib7 6450 1 Background background NN cord-005453-4057qib7 6450 2 : : : cord-005453-4057qib7 6451 1 Acute acute JJ cord-005453-4057qib7 6451 2 graft graft NN cord-005453-4057qib7 6451 3 - - HYPH cord-005453-4057qib7 6451 4 versus versus IN cord-005453-4057qib7 6451 5 - - HYPH cord-005453-4057qib7 6451 6 host host NN cord-005453-4057qib7 6451 7 disease disease NN cord-005453-4057qib7 6451 8 ( ( -LRB- cord-005453-4057qib7 6451 9 aGVHD aGVHD NNP cord-005453-4057qib7 6451 10 ) ) -RRB- cord-005453-4057qib7 6451 11 is be VBZ cord-005453-4057qib7 6451 12 the the DT cord-005453-4057qib7 6451 13 most most RBS cord-005453-4057qib7 6451 14 important important JJ cord-005453-4057qib7 6451 15 complication complication NN cord-005453-4057qib7 6451 16 after after IN cord-005453-4057qib7 6451 17 an an DT cord-005453-4057qib7 6451 18 allogeneic allogeneic JJ cord-005453-4057qib7 6451 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 6451 20 stem stem NN cord-005453-4057qib7 6451 21 cell cell NN cord-005453-4057qib7 6451 22 transplant transplant NN cord-005453-4057qib7 6451 23 ( ( -LRB- cord-005453-4057qib7 6451 24 HSCT HSCT NNP cord-005453-4057qib7 6451 25 ) ) -RRB- cord-005453-4057qib7 6451 26 . . . cord-005453-4057qib7 6452 1 No no DT cord-005453-4057qib7 6452 2 standard standard JJ cord-005453-4057qib7 6452 3 secondline secondline NN cord-005453-4057qib7 6452 4 treatment treatment NN cord-005453-4057qib7 6452 5 has have VBZ cord-005453-4057qib7 6452 6 been be VBN cord-005453-4057qib7 6452 7 established establish VBN cord-005453-4057qib7 6452 8 for for IN cord-005453-4057qib7 6452 9 the the DT cord-005453-4057qib7 6452 10 corticosteroid corticosteroid NN cord-005453-4057qib7 6452 11 refractory refractory JJ cord-005453-4057qib7 6452 12 aGVHD aGVHD NNP cord-005453-4057qib7 6452 13 . . . cord-005453-4057qib7 6453 1 The the DT cord-005453-4057qib7 6453 2 anti anti JJ cord-005453-4057qib7 6453 3 - - JJ cord-005453-4057qib7 6453 4 TNFα tnfα JJ cord-005453-4057qib7 6453 5 agents agent NNS cord-005453-4057qib7 6453 6 are be VBP cord-005453-4057qib7 6453 7 a a DT cord-005453-4057qib7 6453 8 good good JJ cord-005453-4057qib7 6453 9 option option NN cord-005453-4057qib7 6453 10 of of IN cord-005453-4057qib7 6453 11 treatment treatment NN cord-005453-4057qib7 6453 12 for for IN cord-005453-4057qib7 6453 13 these these DT cord-005453-4057qib7 6453 14 patients patient NNS cord-005453-4057qib7 6453 15 , , , cord-005453-4057qib7 6453 16 especially especially RB cord-005453-4057qib7 6453 17 when when WRB cord-005453-4057qib7 6453 18 lower low JJR cord-005453-4057qib7 6453 19 GI GI NNP cord-005453-4057qib7 6453 20 tract tract NN cord-005453-4057qib7 6453 21 is be VBZ cord-005453-4057qib7 6453 22 involved involve VBN cord-005453-4057qib7 6453 23 . . . cord-005453-4057qib7 6454 1 Methods method NNS cord-005453-4057qib7 6454 2 : : : cord-005453-4057qib7 6455 1 From from IN cord-005453-4057qib7 6455 2 April April NNP cord-005453-4057qib7 6455 3 2010 2010 CD cord-005453-4057qib7 6455 4 to to IN cord-005453-4057qib7 6455 5 July July NNP cord-005453-4057qib7 6455 6 2017 2017 CD cord-005453-4057qib7 6455 7 we -PRON- PRP cord-005453-4057qib7 6455 8 reviewed review VBD cord-005453-4057qib7 6455 9 the the DT cord-005453-4057qib7 6455 10 outcome outcome NN cord-005453-4057qib7 6455 11 of of IN cord-005453-4057qib7 6455 12 19 19 CD cord-005453-4057qib7 6455 13 patients patient NNS cord-005453-4057qib7 6455 14 with with IN cord-005453-4057qib7 6455 15 steroid steroid NN cord-005453-4057qib7 6455 16 - - HYPH cord-005453-4057qib7 6455 17 refractory refractory JJ cord-005453-4057qib7 6455 18 ( ( -LRB- cord-005453-4057qib7 6455 19 SR SR NNP cord-005453-4057qib7 6455 20 ) ) -RRB- cord-005453-4057qib7 6455 21 aGVHD aGVHD NNP cord-005453-4057qib7 6455 22 treated treat VBN cord-005453-4057qib7 6455 23 with with IN cord-005453-4057qib7 6455 24 etanercept etanercept NNP cord-005453-4057qib7 6455 25 as as IN cord-005453-4057qib7 6455 26 at at IN cord-005453-4057qib7 6455 27 least least JJS cord-005453-4057qib7 6455 28 , , , cord-005453-4057qib7 6455 29 second second JJ cord-005453-4057qib7 6455 30 line line NN cord-005453-4057qib7 6455 31 treatment treatment NN cord-005453-4057qib7 6455 32 . . . cord-005453-4057qib7 6456 1 Etanercept Etanercept NNP cord-005453-4057qib7 6456 2 dose dose NN cord-005453-4057qib7 6456 3 was be VBD cord-005453-4057qib7 6456 4 25 25 CD cord-005453-4057qib7 6456 5 mg mg NNS cord-005453-4057qib7 6456 6 twice twice PDT cord-005453-4057qib7 6456 7 a a DT cord-005453-4057qib7 6456 8 week week NN cord-005453-4057qib7 6456 9 for for IN cord-005453-4057qib7 6456 10 the the DT cord-005453-4057qib7 6456 11 first first JJ cord-005453-4057qib7 6456 12 4 4 CD cord-005453-4057qib7 6456 13 weeks week NNS cord-005453-4057qib7 6456 14 , , , cord-005453-4057qib7 6456 15 followed follow VBN cord-005453-4057qib7 6456 16 by by IN cord-005453-4057qib7 6456 17 4 4 CD cord-005453-4057qib7 6456 18 weekly weekly JJ cord-005453-4057qib7 6456 19 doses dose NNS cord-005453-4057qib7 6456 20 . . . cord-005453-4057qib7 6457 1 Results result NNS cord-005453-4057qib7 6457 2 : : : cord-005453-4057qib7 6458 1 Median median JJ cord-005453-4057qib7 6458 2 age age NN cord-005453-4057qib7 6458 3 was be VBD cord-005453-4057qib7 6458 4 52 52 CD cord-005453-4057qib7 6458 5 years year NNS cord-005453-4057qib7 6459 1 ( ( -LRB- cord-005453-4057qib7 6459 2 range range NNP cord-005453-4057qib7 6459 3 15 15 CD cord-005453-4057qib7 6459 4 - - SYM cord-005453-4057qib7 6459 5 69 69 CD cord-005453-4057qib7 6459 6 years year NNS cord-005453-4057qib7 6459 7 ) ) -RRB- cord-005453-4057qib7 6459 8 , , , cord-005453-4057qib7 6459 9 and and CC cord-005453-4057qib7 6459 10 12 12 CD cord-005453-4057qib7 6459 11 patients patient NNS cord-005453-4057qib7 6459 12 ( ( -LRB- cord-005453-4057qib7 6459 13 63 63 CD cord-005453-4057qib7 6459 14 % % NN cord-005453-4057qib7 6459 15 ) ) -RRB- cord-005453-4057qib7 6459 16 were be VBD cord-005453-4057qib7 6459 17 male male JJ cord-005453-4057qib7 6459 18 . . . cord-005453-4057qib7 6460 1 Fourteen fourteen CD cord-005453-4057qib7 6460 2 patients patient NNS cord-005453-4057qib7 6460 3 ( ( -LRB- cord-005453-4057qib7 6460 4 74 74 CD cord-005453-4057qib7 6460 5 % % NN cord-005453-4057qib7 6460 6 ) ) -RRB- cord-005453-4057qib7 6460 7 had have VBD cord-005453-4057qib7 6460 8 a a DT cord-005453-4057qib7 6460 9 non non JJ cord-005453-4057qib7 6460 10 - - JJ cord-005453-4057qib7 6460 11 advanced advanced JJ cord-005453-4057qib7 6460 12 disease disease NN cord-005453-4057qib7 6460 13 status status NN cord-005453-4057qib7 6460 14 at at IN cord-005453-4057qib7 6460 15 HSTC HSTC NNP cord-005453-4057qib7 6460 16 . . . cord-005453-4057qib7 6461 1 Eleven eleven CD cord-005453-4057qib7 6461 2 patients patient NNS cord-005453-4057qib7 6461 3 ( ( -LRB- cord-005453-4057qib7 6461 4 59 59 CD cord-005453-4057qib7 6461 5 % % NN cord-005453-4057qib7 6461 6 ) ) -RRB- cord-005453-4057qib7 6461 7 received receive VBD cord-005453-4057qib7 6461 8 a a DT cord-005453-4057qib7 6461 9 myeloablative myeloablative JJ cord-005453-4057qib7 6461 10 conditioning conditioning NN cord-005453-4057qib7 6461 11 , , , cord-005453-4057qib7 6461 12 and and CC cord-005453-4057qib7 6461 13 the the DT cord-005453-4057qib7 6461 14 stem stem NN cord-005453-4057qib7 6461 15 cell cell NN cord-005453-4057qib7 6461 16 source source NN cord-005453-4057qib7 6461 17 was be VBD cord-005453-4057qib7 6461 18 peripheral peripheral JJ cord-005453-4057qib7 6461 19 blood blood NN cord-005453-4057qib7 6461 20 in in IN cord-005453-4057qib7 6461 21 18 18 CD cord-005453-4057qib7 6461 22 patients patient NNS cord-005453-4057qib7 6461 23 ( ( -LRB- cord-005453-4057qib7 6461 24 95 95 CD cord-005453-4057qib7 6461 25 % % NN cord-005453-4057qib7 6461 26 ) ) -RRB- cord-005453-4057qib7 6461 27 . . . cord-005453-4057qib7 6462 1 Sixteen sixteen CD cord-005453-4057qib7 6462 2 patients patient NNS cord-005453-4057qib7 6462 3 ( ( -LRB- cord-005453-4057qib7 6462 4 84 84 CD cord-005453-4057qib7 6462 5 % % NN cord-005453-4057qib7 6462 6 ) ) -RRB- cord-005453-4057qib7 6462 7 were be VBD cord-005453-4057qib7 6462 8 8/8 8/8 CD cord-005453-4057qib7 6462 9 HLA HLA NNP cord-005453-4057qib7 6462 10 matched match VBN cord-005453-4057qib7 6462 11 . . . cord-005453-4057qib7 6463 1 The the DT cord-005453-4057qib7 6463 2 characteristics characteristic NNS cord-005453-4057qib7 6463 3 of of IN cord-005453-4057qib7 6463 4 the the DT cord-005453-4057qib7 6463 5 19 19 CD cord-005453-4057qib7 6463 6 patients patient NNS cord-005453-4057qib7 6463 7 , , , cord-005453-4057qib7 6463 8 their -PRON- PRP$ cord-005453-4057qib7 6463 9 aGVHD aGVHD NNP cord-005453-4057qib7 6463 10 stage stage NN cord-005453-4057qib7 6463 11 previous previous JJ cord-005453-4057qib7 6463 12 to to TO cord-005453-4057qib7 6463 13 rescue rescue VB cord-005453-4057qib7 6463 14 treatment treatment NN cord-005453-4057qib7 6463 15 with with IN cord-005453-4057qib7 6463 16 etanercept etanercept NNP cord-005453-4057qib7 6463 17 and and CC cord-005453-4057qib7 6463 18 their -PRON- PRP$ cord-005453-4057qib7 6463 19 outcome outcome NN cord-005453-4057qib7 6463 20 are be VBP cord-005453-4057qib7 6463 21 shown show VBN cord-005453-4057qib7 6463 22 in in IN cord-005453-4057qib7 6463 23 Table Table NNP cord-005453-4057qib7 6463 24 1 1 CD cord-005453-4057qib7 6463 25 . . . cord-005453-4057qib7 6464 1 Seventeen seventeen CD cord-005453-4057qib7 6464 2 patients patient NNS cord-005453-4057qib7 6464 3 ( ( -LRB- cord-005453-4057qib7 6464 4 89 89 CD cord-005453-4057qib7 6464 5 % % NN cord-005453-4057qib7 6464 6 ) ) -RRB- cord-005453-4057qib7 6464 7 had have VBD cord-005453-4057qib7 6464 8 a a DT cord-005453-4057qib7 6464 9 classic classic JJ cord-005453-4057qib7 6464 10 aGVHD agvhd NN cord-005453-4057qib7 6465 1 while while IN cord-005453-4057qib7 6465 2 2 2 CD cord-005453-4057qib7 6465 3 had have VBD cord-005453-4057qib7 6465 4 a a DT cord-005453-4057qib7 6465 5 late late JJ cord-005453-4057qib7 6465 6 - - HYPH cord-005453-4057qib7 6465 7 onset onset NN cord-005453-4057qib7 6465 8 aGVHD agvhd NN cord-005453-4057qib7 6465 9 . . . cord-005453-4057qib7 6466 1 Etanercept Etanercept NNP cord-005453-4057qib7 6466 2 was be VBD cord-005453-4057qib7 6466 3 given give VBN cord-005453-4057qib7 6466 4 as as IN cord-005453-4057qib7 6466 5 a a DT cord-005453-4057qib7 6466 6 2 2 CD cord-005453-4057qib7 6466 7 nd nd NNP cord-005453-4057qib7 6466 8 , , , cord-005453-4057qib7 6466 9 3 3 CD cord-005453-4057qib7 6466 10 rd rd NNP cord-005453-4057qib7 6466 11 and and CC cord-005453-4057qib7 6466 12 4 4 CD cord-005453-4057qib7 6466 13 th th XX cord-005453-4057qib7 6466 14 line line NN cord-005453-4057qib7 6466 15 in in IN cord-005453-4057qib7 6466 16 3 3 CD cord-005453-4057qib7 6466 17 ( ( -LRB- cord-005453-4057qib7 6466 18 16 16 CD cord-005453-4057qib7 6466 19 % % NN cord-005453-4057qib7 6466 20 ) ) -RRB- cord-005453-4057qib7 6466 21 , , , cord-005453-4057qib7 6466 22 10 10 CD cord-005453-4057qib7 6466 23 ( ( -LRB- cord-005453-4057qib7 6466 24 53 53 CD cord-005453-4057qib7 6466 25 % % NN cord-005453-4057qib7 6466 26 ) ) -RRB- cord-005453-4057qib7 6466 27 and and CC cord-005453-4057qib7 6466 28 6 6 CD cord-005453-4057qib7 6466 29 ( ( -LRB- cord-005453-4057qib7 6466 30 31 31 CD cord-005453-4057qib7 6466 31 % % NN cord-005453-4057qib7 6466 32 ) ) -RRB- cord-005453-4057qib7 6466 33 patients patient NNS cord-005453-4057qib7 6466 34 respectively respectively RB cord-005453-4057qib7 6466 35 . . . cord-005453-4057qib7 6467 1 The the DT cord-005453-4057qib7 6467 2 median median JJ cord-005453-4057qib7 6467 3 doses dose NNS cord-005453-4057qib7 6467 4 of of IN cord-005453-4057qib7 6467 5 etanercept etanercept NNP cord-005453-4057qib7 6467 6 administered administer VBN cord-005453-4057qib7 6467 7 were be VBD cord-005453-4057qib7 6467 8 7 7 CD cord-005453-4057qib7 6468 1 ( ( -LRB- cord-005453-4057qib7 6468 2 range range NNP cord-005453-4057qib7 6468 3 1 1 CD cord-005453-4057qib7 6468 4 - - SYM cord-005453-4057qib7 6468 5 12 12 CD cord-005453-4057qib7 6468 6 ) ) -RRB- cord-005453-4057qib7 6468 7 , , , cord-005453-4057qib7 6468 8 and and CC cord-005453-4057qib7 6468 9 just just RB cord-005453-4057qib7 6468 10 4 4 CD cord-005453-4057qib7 6468 11 patients patient NNS cord-005453-4057qib7 6468 12 ( ( -LRB- cord-005453-4057qib7 6468 13 20 20 CD cord-005453-4057qib7 6468 14 % % NN cord-005453-4057qib7 6468 15 ) ) -RRB- cord-005453-4057qib7 6468 16 completed complete VBD cord-005453-4057qib7 6468 17 the the DT cord-005453-4057qib7 6468 18 12 12 CD cord-005453-4057qib7 6468 19 doses dose NNS cord-005453-4057qib7 6468 20 planned plan VBN cord-005453-4057qib7 6468 21 treatment treatment NN cord-005453-4057qib7 6468 22 , , , cord-005453-4057qib7 6468 23 of of IN cord-005453-4057qib7 6468 24 whom whom WP cord-005453-4057qib7 6468 25 3 3 CD cord-005453-4057qib7 6468 26 were be VBD cord-005453-4057qib7 6468 27 alive alive JJ cord-005453-4057qib7 6468 28 at at IN cord-005453-4057qib7 6468 29 38 38 CD cord-005453-4057qib7 6468 30 , , , cord-005453-4057qib7 6468 31 24 24 CD cord-005453-4057qib7 6468 32 and and CC cord-005453-4057qib7 6468 33 18 18 CD cord-005453-4057qib7 6468 34 months month NNS cord-005453-4057qib7 6468 35 from from IN cord-005453-4057qib7 6468 36 the the DT cord-005453-4057qib7 6468 37 onset onset NN cord-005453-4057qib7 6468 38 of of IN cord-005453-4057qib7 6468 39 rescue rescue NN cord-005453-4057qib7 6468 40 treatment treatment NN cord-005453-4057qib7 6468 41 . . . cord-005453-4057qib7 6469 1 Complications complication NNS cord-005453-4057qib7 6469 2 during during IN cord-005453-4057qib7 6469 3 etanercept etanercept NNP cord-005453-4057qib7 6469 4 treatment treatment NN cord-005453-4057qib7 6469 5 were be VBD cord-005453-4057qib7 6469 6 : : : cord-005453-4057qib7 6469 7 infection infection NN cord-005453-4057qib7 6469 8 ( ( -LRB- cord-005453-4057qib7 6469 9 n=9 n=9 NN cord-005453-4057qib7 6469 10 [ [ -LRB- cord-005453-4057qib7 6469 11 47 47 CD cord-005453-4057qib7 6469 12 % % NN cord-005453-4057qib7 6469 13 ] ] -RRB- cord-005453-4057qib7 6469 14 : : : cord-005453-4057qib7 6469 15 gram gram NN cord-005453-4057qib7 6469 16 negative negative JJ cord-005453-4057qib7 6469 17 bacilli bacilli NN cord-005453-4057qib7 6469 18 [ [ -LRB- cord-005453-4057qib7 6469 19 n=6 n=6 NN cord-005453-4057qib7 6469 20 ] ] -RRB- cord-005453-4057qib7 6469 21 ) ) -RRB- cord-005453-4057qib7 6469 22 , , , cord-005453-4057qib7 6469 23 grade grade NN cord-005453-4057qib7 6469 24 2 2 CD cord-005453-4057qib7 6469 25 - - SYM cord-005453-4057qib7 6469 26 4 4 CD cord-005453-4057qib7 6469 27 neutropenia neutropenia NN cord-005453-4057qib7 6469 28 ( ( -LRB- cord-005453-4057qib7 6469 29 n=8 n=8 NN cord-005453-4057qib7 6469 30 ) ) -RRB- cord-005453-4057qib7 6469 31 and and CC cord-005453-4057qib7 6469 32 grade grade NN cord-005453-4057qib7 6469 33 3 3 CD cord-005453-4057qib7 6469 34 - - SYM cord-005453-4057qib7 6469 35 4 4 CD cord-005453-4057qib7 6469 36 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 6469 37 ( ( -LRB- cord-005453-4057qib7 6469 38 n=6 n=6 NNP cord-005453-4057qib7 6469 39 ) ) -RRB- cord-005453-4057qib7 6469 40 . . . cord-005453-4057qib7 6470 1 Etanercept Etanercept NNP cord-005453-4057qib7 6470 2 was be VBD cord-005453-4057qib7 6470 3 indicated indicate VBN cord-005453-4057qib7 6470 4 as as IN cord-005453-4057qib7 6470 5 a a DT cord-005453-4057qib7 6470 6 rescue rescue NN cord-005453-4057qib7 6470 7 treatment treatment NN cord-005453-4057qib7 6470 8 due due IN cord-005453-4057qib7 6470 9 to to IN cord-005453-4057qib7 6470 10 : : : cord-005453-4057qib7 6470 11 progression progression NN cord-005453-4057qib7 6470 12 after after IN cord-005453-4057qib7 6470 13 3 3 CD cord-005453-4057qib7 6470 14 days day NNS cord-005453-4057qib7 6470 15 of of IN cord-005453-4057qib7 6470 16 aGVHD aGVHD NNP cord-005453-4057qib7 6470 17 treatment treatment NN cord-005453-4057qib7 6470 18 ( ( -LRB- cord-005453-4057qib7 6470 19 n=1 n=1 CD cord-005453-4057qib7 6470 20 ) ) -RRB- cord-005453-4057qib7 6470 21 , , , cord-005453-4057qib7 6470 22 no no DT cord-005453-4057qib7 6470 23 response response NN cord-005453-4057qib7 6470 24 after after IN cord-005453-4057qib7 6470 25 7 7 CD cord-005453-4057qib7 6470 26 days day NNS cord-005453-4057qib7 6470 27 of of IN cord-005453-4057qib7 6470 28 treatment treatment NN cord-005453-4057qib7 6470 29 ( ( -LRB- cord-005453-4057qib7 6470 30 n=11 n=11 NNP cord-005453-4057qib7 6470 31 ) ) -RRB- cord-005453-4057qib7 6470 32 , , , cord-005453-4057qib7 6470 33 no no DT cord-005453-4057qib7 6470 34 complete complete JJ cord-005453-4057qib7 6470 35 remission remission NN cord-005453-4057qib7 6470 36 after after IN cord-005453-4057qib7 6470 37 14 14 CD cord-005453-4057qib7 6470 38 days day NNS cord-005453-4057qib7 6470 39 of of IN cord-005453-4057qib7 6470 40 treatment treatment NN cord-005453-4057qib7 6470 41 ( ( -LRB- cord-005453-4057qib7 6470 42 n=3 n=3 NN cord-005453-4057qib7 6470 43 ) ) -RRB- cord-005453-4057qib7 6470 44 and and CC cord-005453-4057qib7 6470 45 relapse relapse VB cord-005453-4057qib7 6470 46 due due IN cord-005453-4057qib7 6470 47 to to TO cord-005453-4057qib7 6470 48 decrease decrease VB cord-005453-4057qib7 6470 49 corticosteroid corticosteroid NN cord-005453-4057qib7 6470 50 doses dose NNS cord-005453-4057qib7 6470 51 ( ( -LRB- cord-005453-4057qib7 6470 52 n=4 n=4 NNS cord-005453-4057qib7 6470 53 ) ) -RRB- cord-005453-4057qib7 6470 54 . . . cord-005453-4057qib7 6471 1 At at IN cord-005453-4057qib7 6471 2 the the DT cord-005453-4057qib7 6471 3 end end NN cord-005453-4057qib7 6471 4 of of IN cord-005453-4057qib7 6471 5 treatment treatment NN cord-005453-4057qib7 6471 6 1 1 CD cord-005453-4057qib7 6471 7 patient patient NN cord-005453-4057qib7 6471 8 achieved achieve VBD cord-005453-4057qib7 6471 9 a a DT cord-005453-4057qib7 6471 10 complete complete JJ cord-005453-4057qib7 6471 11 response response NN cord-005453-4057qib7 6471 12 and and CC cord-005453-4057qib7 6471 13 3 3 CD cord-005453-4057qib7 6471 14 patients patient NNS cord-005453-4057qib7 6471 15 a a DT cord-005453-4057qib7 6471 16 partial partial JJ cord-005453-4057qib7 6471 17 response response NN cord-005453-4057qib7 6471 18 , , , cord-005453-4057qib7 6471 19 all all DT cord-005453-4057qib7 6471 20 of of IN cord-005453-4057qib7 6471 21 them -PRON- PRP cord-005453-4057qib7 6471 22 are be VBP cord-005453-4057qib7 6471 23 alive alive JJ cord-005453-4057qib7 6471 24 . . . cord-005453-4057qib7 6472 1 These these DT cord-005453-4057qib7 6472 2 4 4 CD cord-005453-4057qib7 6472 3 patients patient NNS cord-005453-4057qib7 6472 4 received receive VBD cord-005453-4057qib7 6472 5 etanercept etanercept NNP cord-005453-4057qib7 6472 6 as as IN cord-005453-4057qib7 6472 7 a a DT cord-005453-4057qib7 6472 8 2 2 CD cord-005453-4057qib7 6472 9 nd nd NNP cord-005453-4057qib7 6472 10 ( ( -LRB- cord-005453-4057qib7 6472 11 n=3 n=3 NN cord-005453-4057qib7 6472 12 ) ) -RRB- cord-005453-4057qib7 6472 13 and and CC cord-005453-4057qib7 6472 14 3th 3th JJ cord-005453-4057qib7 6472 15 line line NN cord-005453-4057qib7 6472 16 ( ( -LRB- cord-005453-4057qib7 6472 17 n=1 n=1 CD cord-005453-4057qib7 6472 18 ) ) -RRB- cord-005453-4057qib7 6472 19 treatment treatment NN cord-005453-4057qib7 6472 20 , , , cord-005453-4057qib7 6472 21 all all DT cord-005453-4057qib7 6472 22 of of IN cord-005453-4057qib7 6472 23 them -PRON- PRP cord-005453-4057qib7 6472 24 had have VBD cord-005453-4057qib7 6472 25 lower low JJR cord-005453-4057qib7 6472 26 GI GI NNP cord-005453-4057qib7 6472 27 aGVHD agvhd NN cord-005453-4057qib7 6473 1 without without IN cord-005453-4057qib7 6473 2 any any DT cord-005453-4057qib7 6473 3 other other JJ cord-005453-4057qib7 6473 4 organ organ NN cord-005453-4057qib7 6473 5 significantly significantly RB cord-005453-4057qib7 6473 6 involved involve VBN cord-005453-4057qib7 6473 7 . . . cord-005453-4057qib7 6474 1 Causes cause NNS cord-005453-4057qib7 6474 2 of of IN cord-005453-4057qib7 6474 3 death death NN cord-005453-4057qib7 6474 4 were be VBD cord-005453-4057qib7 6474 5 : : : cord-005453-4057qib7 6474 6 aGVHD aGVHD NNP cord-005453-4057qib7 6474 7 with with IN cord-005453-4057qib7 6474 8 or or CC cord-005453-4057qib7 6474 9 without without IN cord-005453-4057qib7 6474 10 infection infection NN cord-005453-4057qib7 6474 11 in in IN cord-005453-4057qib7 6474 12 15 15 CD cord-005453-4057qib7 6474 13 patients patient NNS cord-005453-4057qib7 6474 14 ( ( -LRB- cord-005453-4057qib7 6474 15 78 78 CD cord-005453-4057qib7 6474 16 % % NN cord-005453-4057qib7 6474 17 ) ) -RRB- cord-005453-4057qib7 6474 18 and and CC cord-005453-4057qib7 6474 19 leukemia leukemia NN cord-005453-4057qib7 6474 20 relapse relapse NN cord-005453-4057qib7 6474 21 in in IN cord-005453-4057qib7 6474 22 1 1 CD cord-005453-4057qib7 6474 23 patient patient NN cord-005453-4057qib7 6474 24 . . . cord-005453-4057qib7 6475 1 Conclusions conclusion NNS cord-005453-4057qib7 6475 2 : : : cord-005453-4057qib7 6476 1 Although although IN cord-005453-4057qib7 6476 2 if if IN cord-005453-4057qib7 6476 3 etanercept etanercept NNP cord-005453-4057qib7 6476 4 is be VBZ cord-005453-4057qib7 6476 5 an an DT cord-005453-4057qib7 6476 6 option option NN cord-005453-4057qib7 6476 7 for for IN cord-005453-4057qib7 6476 8 treatment treatment NN cord-005453-4057qib7 6476 9 of of IN cord-005453-4057qib7 6476 10 SR SR NNP cord-005453-4057qib7 6476 11 aGVHD aGVHD NNP cord-005453-4057qib7 6476 12 in in IN cord-005453-4057qib7 6476 13 some some DT cord-005453-4057qib7 6476 14 patients patient NNS cord-005453-4057qib7 6476 15 , , , cord-005453-4057qib7 6476 16 their -PRON- PRP$ cord-005453-4057qib7 6476 17 prognostic prognostic JJ cord-005453-4057qib7 6476 18 remains remain VBZ cord-005453-4057qib7 6476 19 poor poor JJ cord-005453-4057qib7 6476 20 and and CC cord-005453-4057qib7 6476 21 more more RBR cord-005453-4057qib7 6476 22 effective effective JJ cord-005453-4057qib7 6476 23 alternative alternative JJ cord-005453-4057qib7 6476 24 strategies strategy NNS cord-005453-4057qib7 6476 25 are be VBP cord-005453-4057qib7 6476 26 needed need VBN cord-005453-4057qib7 6476 27 . . . cord-005453-4057qib7 6477 1 A a DT cord-005453-4057qib7 6477 2 prompt prompt JJ cord-005453-4057qib7 6477 3 initiation initiation NN cord-005453-4057qib7 6477 4 of of IN cord-005453-4057qib7 6477 5 etanercept etanercept NNP cord-005453-4057qib7 6477 6 as as IN cord-005453-4057qib7 6477 7 a a DT cord-005453-4057qib7 6477 8 rescue rescue NN cord-005453-4057qib7 6477 9 treatment treatment NN cord-005453-4057qib7 6477 10 for for IN cord-005453-4057qib7 6477 11 SR SR NNP cord-005453-4057qib7 6477 12 aGVHD aGVHD NNP cord-005453-4057qib7 6477 13 is be VBZ cord-005453-4057qib7 6477 14 crucial crucial JJ cord-005453-4057qib7 6477 15 to to TO cord-005453-4057qib7 6477 16 improve improve VB cord-005453-4057qib7 6477 17 the the DT cord-005453-4057qib7 6477 18 prognosis prognosis NN cord-005453-4057qib7 6477 19 . . . cord-005453-4057qib7 6478 1 ( ( -LRB- cord-005453-4057qib7 6478 2 58 58 CD cord-005453-4057qib7 6478 3 ) ) -RRB- cord-005453-4057qib7 6478 4 5(26 5(26 CD cord-005453-4057qib7 6478 5 ) ) -RRB- cord-005453-4057qib7 6479 1 Background background NN cord-005453-4057qib7 6479 2 : : : cord-005453-4057qib7 6480 1 Although although IN cord-005453-4057qib7 6480 2 both both CC cord-005453-4057qib7 6480 3 cyclosporine cyclosporine NN cord-005453-4057qib7 6480 4 ( ( -LRB- cord-005453-4057qib7 6480 5 CSA CSA NNP cord-005453-4057qib7 6480 6 ) ) -RRB- cord-005453-4057qib7 6480 7 and and CC cord-005453-4057qib7 6480 8 tacrolimus tacrolimus NNP cord-005453-4057qib7 6480 9 are be VBP cord-005453-4057qib7 6480 10 calcineurin calcineurin NNP cord-005453-4057qib7 6480 11 inhibitors inhibitor NNS cord-005453-4057qib7 6480 12 , , , cord-005453-4057qib7 6480 13 CSA CSA NNP cord-005453-4057qib7 6480 14 is be VBZ cord-005453-4057qib7 6480 15 more more RBR cord-005453-4057qib7 6480 16 widely widely RB cord-005453-4057qib7 6480 17 used use VBN cord-005453-4057qib7 6480 18 in in IN cord-005453-4057qib7 6480 19 pediatric pediatric JJ cord-005453-4057qib7 6480 20 hematopoetic hematopoetic JJ cord-005453-4057qib7 6480 21 stem stem NN cord-005453-4057qib7 6480 22 cell cell NN cord-005453-4057qib7 6480 23 transplantation transplantation NN cord-005453-4057qib7 6480 24 ( ( -LRB- cord-005453-4057qib7 6480 25 HSCT HSCT NNP cord-005453-4057qib7 6480 26 ) ) -RRB- cord-005453-4057qib7 6480 27 as as IN cord-005453-4057qib7 6480 28 a a DT cord-005453-4057qib7 6480 29 prophylactic prophylactic JJ cord-005453-4057qib7 6480 30 drug drug NN cord-005453-4057qib7 6480 31 for for IN cord-005453-4057qib7 6480 32 acute acute JJ cord-005453-4057qib7 6480 33 graft graft NN cord-005453-4057qib7 6480 34 versus versus IN cord-005453-4057qib7 6480 35 host host NN cord-005453-4057qib7 6480 36 disease disease NN cord-005453-4057qib7 6480 37 ( ( -LRB- cord-005453-4057qib7 6480 38 aGvHD agvhd NN cord-005453-4057qib7 6480 39 ) ) -RRB- cord-005453-4057qib7 6480 40 . . . cord-005453-4057qib7 6481 1 There there EX cord-005453-4057qib7 6481 2 are be VBP cord-005453-4057qib7 6481 3 some some DT cord-005453-4057qib7 6481 4 clinical clinical JJ cord-005453-4057qib7 6481 5 experience experience NN cord-005453-4057qib7 6481 6 but but CC cord-005453-4057qib7 6481 7 very very RB cord-005453-4057qib7 6481 8 few few JJ cord-005453-4057qib7 6481 9 data datum NNS cord-005453-4057qib7 6481 10 about about IN cord-005453-4057qib7 6481 11 the the DT cord-005453-4057qib7 6481 12 clinical clinical JJ cord-005453-4057qib7 6481 13 efficacy efficacy NN cord-005453-4057qib7 6481 14 of of IN cord-005453-4057qib7 6481 15 conversion conversion NN cord-005453-4057qib7 6481 16 to to IN cord-005453-4057qib7 6481 17 tacrolimus tacrolimus NNP cord-005453-4057qib7 6481 18 . . . cord-005453-4057qib7 6482 1 Here here RB cord-005453-4057qib7 6482 2 , , , cord-005453-4057qib7 6482 3 we -PRON- PRP cord-005453-4057qib7 6482 4 present present VBP cord-005453-4057qib7 6482 5 our -PRON- PRP$ cord-005453-4057qib7 6482 6 single single JJ cord-005453-4057qib7 6482 7 center center NN cord-005453-4057qib7 6482 8 data datum NNS cord-005453-4057qib7 6482 9 on on IN cord-005453-4057qib7 6482 10 this this DT cord-005453-4057qib7 6482 11 arguable arguable JJ cord-005453-4057qib7 6482 12 topic topic NN cord-005453-4057qib7 6482 13 . . . cord-005453-4057qib7 6483 1 Methods method NNS cord-005453-4057qib7 6483 2 : : : cord-005453-4057qib7 6483 3 This this DT cord-005453-4057qib7 6483 4 study study NN cord-005453-4057qib7 6483 5 involves involve VBZ cord-005453-4057qib7 6483 6 the the DT cord-005453-4057qib7 6483 7 data datum NNS cord-005453-4057qib7 6483 8 of of IN cord-005453-4057qib7 6483 9 71 71 CD cord-005453-4057qib7 6483 10 pediatric pediatric JJ cord-005453-4057qib7 6483 11 HSCT HSCT NNP cord-005453-4057qib7 6483 12 patients patient NNS cord-005453-4057qib7 6483 13 in in IN cord-005453-4057qib7 6483 14 Medical Medical NNP cord-005453-4057qib7 6483 15 Park Park NNP cord-005453-4057qib7 6483 16 Göztepe Göztepe NNP cord-005453-4057qib7 6483 17 Hospital Hospital NNP cord-005453-4057qib7 6483 18 between between IN cord-005453-4057qib7 6483 19 2014 2014 CD cord-005453-4057qib7 6483 20 - - SYM cord-005453-4057qib7 6483 21 2018 2018 CD cord-005453-4057qib7 6483 22 . . . cord-005453-4057qib7 6484 1 All all DT cord-005453-4057qib7 6484 2 71 71 CD cord-005453-4057qib7 6484 3 patients patient NNS cord-005453-4057qib7 6484 4 had have VBD cord-005453-4057qib7 6484 5 prophylactic prophylactic JJ cord-005453-4057qib7 6484 6 CSA CSA NNP cord-005453-4057qib7 6484 7 therapy therapy NN cord-005453-4057qib7 6484 8 and and CC cord-005453-4057qib7 6484 9 for for IN cord-005453-4057qib7 6484 10 various various JJ cord-005453-4057qib7 6484 11 reasons reason NNS cord-005453-4057qib7 6484 12 CSA CSA NNP cord-005453-4057qib7 6484 13 was be VBD cord-005453-4057qib7 6484 14 converted convert VBN cord-005453-4057qib7 6484 15 to to IN cord-005453-4057qib7 6484 16 tacrolimus tacrolimus NN cord-005453-4057qib7 6484 17 therapy therapy NN cord-005453-4057qib7 6484 18 . . . cord-005453-4057qib7 6485 1 Most Most JJS cord-005453-4057qib7 6485 2 of of IN cord-005453-4057qib7 6485 3 the the DT cord-005453-4057qib7 6485 4 patients patient NNS cord-005453-4057qib7 6485 5 had have VBD cord-005453-4057qib7 6485 6 this this DT cord-005453-4057qib7 6485 7 conversion conversion NN cord-005453-4057qib7 6485 8 due due IN cord-005453-4057qib7 6485 9 to to IN cord-005453-4057qib7 6485 10 aGvHD agvhd NN cord-005453-4057qib7 6485 11 . . . cord-005453-4057qib7 6486 1 As as IN cord-005453-4057qib7 6486 2 steroid steroid NN cord-005453-4057qib7 6486 3 is be VBZ cord-005453-4057qib7 6486 4 the the DT cord-005453-4057qib7 6486 5 first first JJ cord-005453-4057qib7 6486 6 line line NN cord-005453-4057qib7 6486 7 therapy therapy NN cord-005453-4057qib7 6486 8 for for IN cord-005453-4057qib7 6486 9 aGvHD agvhd NN cord-005453-4057qib7 6486 10 , , , cord-005453-4057qib7 6486 11 conversion conversion NN cord-005453-4057qib7 6486 12 to to IN cord-005453-4057qib7 6486 13 tacrolimus tacrolimus NNP cord-005453-4057qib7 6486 14 is be VBZ cord-005453-4057qib7 6486 15 done do VBN cord-005453-4057qib7 6486 16 concurrently concurrently RB cord-005453-4057qib7 6486 17 at at IN cord-005453-4057qib7 6486 18 the the DT cord-005453-4057qib7 6486 19 start start NN cord-005453-4057qib7 6486 20 of of IN cord-005453-4057qib7 6486 21 steroid steroid NN cord-005453-4057qib7 6486 22 therapy therapy NN cord-005453-4057qib7 6486 23 ( ( -LRB- cord-005453-4057qib7 6486 24 within within IN cord-005453-4057qib7 6486 25 72 72 CD cord-005453-4057qib7 6486 26 hours hour NNS cord-005453-4057qib7 6486 27 after after IN cord-005453-4057qib7 6486 28 the the DT cord-005453-4057qib7 6486 29 start start NN cord-005453-4057qib7 6486 30 of of IN cord-005453-4057qib7 6486 31 steroid steroid NN cord-005453-4057qib7 6486 32 ) ) -RRB- cord-005453-4057qib7 6486 33 . . . cord-005453-4057qib7 6487 1 And and CC cord-005453-4057qib7 6487 2 also also RB cord-005453-4057qib7 6487 3 , , , cord-005453-4057qib7 6487 4 patients patient NNS cord-005453-4057qib7 6487 5 who who WP cord-005453-4057qib7 6487 6 had have VBD cord-005453-4057qib7 6487 7 any any DT cord-005453-4057qib7 6487 8 other other JJ cord-005453-4057qib7 6487 9 immunosupressive immunosupressive JJ cord-005453-4057qib7 6487 10 therapy therapy NN cord-005453-4057qib7 6487 11 for for IN cord-005453-4057qib7 6487 12 aGvHD aGvHD NNP cord-005453-4057qib7 6487 13 are be VBP cord-005453-4057qib7 6487 14 excluded exclude VBN cord-005453-4057qib7 6487 15 . . . cord-005453-4057qib7 6488 1 Response response NN cord-005453-4057qib7 6488 2 is be VBZ cord-005453-4057qib7 6488 3 defined define VBN cord-005453-4057qib7 6488 4 as as IN cord-005453-4057qib7 6488 5 resolution resolution NN cord-005453-4057qib7 6488 6 of of IN cord-005453-4057qib7 6488 7 symptoms symptom NNS cord-005453-4057qib7 6488 8 within within IN cord-005453-4057qib7 6488 9 7 7 CD cord-005453-4057qib7 6488 10 days day NNS cord-005453-4057qib7 6488 11 after after IN cord-005453-4057qib7 6488 12 conversion conversion NN cord-005453-4057qib7 6488 13 . . . cord-005453-4057qib7 6489 1 Results result NNS cord-005453-4057qib7 6489 2 : : : cord-005453-4057qib7 6490 1 Mean mean JJ cord-005453-4057qib7 6490 2 age age NN cord-005453-4057qib7 6490 3 of of IN cord-005453-4057qib7 6490 4 the the DT cord-005453-4057qib7 6490 5 study study NN cord-005453-4057qib7 6490 6 population population NN cord-005453-4057qib7 6490 7 is be VBZ cord-005453-4057qib7 6490 8 130 130 CD cord-005453-4057qib7 6490 9 months month NNS cord-005453-4057qib7 6490 10 ( ( -LRB- cord-005453-4057qib7 6490 11 5 5 CD cord-005453-4057qib7 6490 12 - - SYM cord-005453-4057qib7 6490 13 266 266 CD cord-005453-4057qib7 6490 14 months month NNS cord-005453-4057qib7 6490 15 ) ) -RRB- cord-005453-4057qib7 6490 16 , , , cord-005453-4057qib7 6490 17 male male JJ cord-005453-4057qib7 6490 18 / / SYM cord-005453-4057qib7 6490 19 female female JJ cord-005453-4057qib7 6490 20 ratio ratio NN cord-005453-4057qib7 6490 21 is be VBZ cord-005453-4057qib7 6490 22 1,3 1,3 CD cord-005453-4057qib7 6490 23 ( ( -LRB- cord-005453-4057qib7 6490 24 40/31 40/31 CD cord-005453-4057qib7 6490 25 ) ) -RRB- cord-005453-4057qib7 6490 26 , , , cord-005453-4057qib7 6490 27 donor donor NN cord-005453-4057qib7 6490 28 types type NNS cord-005453-4057qib7 6490 29 are be VBP cord-005453-4057qib7 6490 30 MUD mud NN cord-005453-4057qib7 6490 31 48 48 CD cord-005453-4057qib7 6490 32 patients patient NNS cord-005453-4057qib7 6490 33 ( ( -LRB- cord-005453-4057qib7 6490 34 67 67 CD cord-005453-4057qib7 6490 35 % % NN cord-005453-4057qib7 6490 36 ) ) -RRB- cord-005453-4057qib7 6490 37 , , , cord-005453-4057qib7 6490 38 MFD MFD NNP cord-005453-4057qib7 6490 39 18 18 CD cord-005453-4057qib7 6490 40 patients patient NNS cord-005453-4057qib7 6490 41 ( ( -LRB- cord-005453-4057qib7 6490 42 26 26 CD cord-005453-4057qib7 6490 43 % % NN cord-005453-4057qib7 6490 44 ) ) -RRB- cord-005453-4057qib7 6490 45 , , , cord-005453-4057qib7 6490 46 haplo haplo NNP cord-005453-4057qib7 6491 1 5 5 CD cord-005453-4057qib7 6491 2 patients patient NNS cord-005453-4057qib7 6491 3 ( ( -LRB- cord-005453-4057qib7 6491 4 7 7 CD cord-005453-4057qib7 6491 5 % % NN cord-005453-4057qib7 6491 6 ) ) -RRB- cord-005453-4057qib7 6491 7 and and CC cord-005453-4057qib7 6491 8 mean mean VB cord-005453-4057qib7 6491 9 conversion conversion NN cord-005453-4057qib7 6491 10 time time NN cord-005453-4057qib7 6491 11 is be VBZ cord-005453-4057qib7 6491 12 32 32 CD cord-005453-4057qib7 6491 13 days day NNS cord-005453-4057qib7 6491 14 ( ( -LRB- cord-005453-4057qib7 6491 15 1 1 CD cord-005453-4057qib7 6491 16 - - SYM cord-005453-4057qib7 6491 17 142 142 CD cord-005453-4057qib7 6491 18 days day NNS cord-005453-4057qib7 6491 19 ) ) -RRB- cord-005453-4057qib7 6491 20 . . . cord-005453-4057qib7 6492 1 The the DT cord-005453-4057qib7 6492 2 rationales rationale NNS cord-005453-4057qib7 6492 3 for for IN cord-005453-4057qib7 6492 4 conversion conversion NN cord-005453-4057qib7 6492 5 are be VBP cord-005453-4057qib7 6492 6 aGvHD agvhd NN cord-005453-4057qib7 6492 7 for for IN cord-005453-4057qib7 6492 8 40 40 CD cord-005453-4057qib7 6492 9 patients patient NNS cord-005453-4057qib7 6492 10 , , , cord-005453-4057qib7 6492 11 unproper unproper JJ cord-005453-4057qib7 6492 12 CSA CSA NNP cord-005453-4057qib7 6492 13 plasma plasma NN cord-005453-4057qib7 6492 14 levels level NNS cord-005453-4057qib7 6492 15 for for IN cord-005453-4057qib7 6492 16 7 7 CD cord-005453-4057qib7 6492 17 patients patient NNS cord-005453-4057qib7 6492 18 , , , cord-005453-4057qib7 6492 19 allergic allergic JJ cord-005453-4057qib7 6492 20 reaction reaction NN cord-005453-4057qib7 6492 21 for for IN cord-005453-4057qib7 6492 22 6 6 CD cord-005453-4057qib7 6492 23 patients patient NNS cord-005453-4057qib7 6492 24 , , , cord-005453-4057qib7 6492 25 nephrotoxicity nephrotoxicity NN cord-005453-4057qib7 6492 26 for for IN cord-005453-4057qib7 6492 27 6 6 CD cord-005453-4057qib7 6492 28 patients patient NNS cord-005453-4057qib7 6492 29 , , , cord-005453-4057qib7 6492 30 hepatotoxicity hepatotoxicity NN cord-005453-4057qib7 6492 31 for for IN cord-005453-4057qib7 6492 32 5 5 CD cord-005453-4057qib7 6492 33 patients patient NNS cord-005453-4057qib7 6492 34 , , , cord-005453-4057qib7 6492 35 severe severe JJ cord-005453-4057qib7 6492 36 headache headache NN cord-005453-4057qib7 6492 37 for for IN cord-005453-4057qib7 6492 38 2 2 CD cord-005453-4057qib7 6492 39 patients patient NNS cord-005453-4057qib7 6492 40 , , , cord-005453-4057qib7 6492 41 high high JJ cord-005453-4057qib7 6492 42 arterial arterial JJ cord-005453-4057qib7 6492 43 blood blood NN cord-005453-4057qib7 6492 44 pressure pressure NN cord-005453-4057qib7 6492 45 for for IN cord-005453-4057qib7 6492 46 2 2 CD cord-005453-4057qib7 6492 47 patients patient NNS cord-005453-4057qib7 6492 48 and and CC cord-005453-4057qib7 6492 49 one one CD cord-005453-4057qib7 6492 50 each each DT cord-005453-4057qib7 6492 51 for for IN cord-005453-4057qib7 6492 52 refractory refractory JJ cord-005453-4057qib7 6492 53 vomiting vomiting NN cord-005453-4057qib7 6492 54 , , , cord-005453-4057qib7 6492 55 autoimmune autoimmune JJ cord-005453-4057qib7 6492 56 thyroiditis thyroiditis NN cord-005453-4057qib7 6492 57 and and CC cord-005453-4057qib7 6492 58 visual visual JJ cord-005453-4057qib7 6492 59 disturbance disturbance NN cord-005453-4057qib7 6492 60 . . . cord-005453-4057qib7 6493 1 The the DT cord-005453-4057qib7 6493 2 subgroup subgroup NN cord-005453-4057qib7 6493 3 analysis analysis NN cord-005453-4057qib7 6493 4 of of IN cord-005453-4057qib7 6493 5 aGvHD agvhd NN cord-005453-4057qib7 6493 6 patients patient NNS cord-005453-4057qib7 6493 7 reveals reveal VBZ cord-005453-4057qib7 6493 8 that that IN cord-005453-4057qib7 6493 9 mean mean VBP cord-005453-4057qib7 6493 10 conversion conversion NN cord-005453-4057qib7 6493 11 time time NN cord-005453-4057qib7 6493 12 for for IN cord-005453-4057qib7 6493 13 aGvHD agvhd NN cord-005453-4057qib7 6493 14 is be VBZ cord-005453-4057qib7 6493 15 41 41 CD cord-005453-4057qib7 6493 16 days day NNS cord-005453-4057qib7 6493 17 ( ( -LRB- cord-005453-4057qib7 6493 18 8 8 CD cord-005453-4057qib7 6493 19 - - SYM cord-005453-4057qib7 6493 20 142 142 CD cord-005453-4057qib7 6493 21 days day NNS cord-005453-4057qib7 6493 22 ) ) -RRB- cord-005453-4057qib7 6493 23 and and CC cord-005453-4057qib7 6493 24 there there EX cord-005453-4057qib7 6493 25 are be VBP cord-005453-4057qib7 6493 26 only only RB cord-005453-4057qib7 6493 27 11 11 CD cord-005453-4057qib7 6493 28 responders responder NNS cord-005453-4057qib7 6493 29 whose whose WP$ cord-005453-4057qib7 6493 30 aGvHD aGvHD . cord-005453-4057qib7 6493 31 resolve resolve VB cord-005453-4057qib7 6493 32 completely completely RB cord-005453-4057qib7 6493 33 ( ( -LRB- cord-005453-4057qib7 6493 34 % % NN cord-005453-4057qib7 6493 35 27 27 CD cord-005453-4057qib7 6493 36 ) ) -RRB- cord-005453-4057qib7 6493 37 after after IN cord-005453-4057qib7 6493 38 conversion conversion NN cord-005453-4057qib7 6493 39 . . . cord-005453-4057qib7 6494 1 All all DT cord-005453-4057qib7 6494 2 of of IN cord-005453-4057qib7 6494 3 the the DT cord-005453-4057qib7 6494 4 patients patient NNS cord-005453-4057qib7 6494 5 had have VBD cord-005453-4057qib7 6494 6 proper proper JJ cord-005453-4057qib7 6494 7 tacrolimus tacrolimus NN cord-005453-4057qib7 6494 8 levels level NNS cord-005453-4057qib7 6494 9 after after IN cord-005453-4057qib7 6494 10 conversion conversion NN cord-005453-4057qib7 6494 11 due due IN cord-005453-4057qib7 6494 12 to to IN cord-005453-4057qib7 6494 13 unproper unproper JJ cord-005453-4057qib7 6494 14 CSA CSA NNP cord-005453-4057qib7 6494 15 levels level NNS cord-005453-4057qib7 6494 16 and and CC cord-005453-4057qib7 6494 17 also also RB cord-005453-4057qib7 6494 18 patients patient NNS cord-005453-4057qib7 6494 19 in in IN cord-005453-4057qib7 6494 20 allegic allegic JJ cord-005453-4057qib7 6494 21 reaction reaction NN cord-005453-4057qib7 6494 22 , , , cord-005453-4057qib7 6494 23 severe severe JJ cord-005453-4057qib7 6494 24 headache headache NN cord-005453-4057qib7 6494 25 , , , cord-005453-4057qib7 6494 26 visiual visiual JJ cord-005453-4057qib7 6494 27 disturbance disturbance NN cord-005453-4057qib7 6494 28 and and CC cord-005453-4057qib7 6494 29 refractory refractory JJ cord-005453-4057qib7 6494 30 vomiting vomiting NN cord-005453-4057qib7 6494 31 group group NN cord-005453-4057qib7 6494 32 responded respond VBD cord-005453-4057qib7 6494 33 to to IN cord-005453-4057qib7 6494 34 conversion conversion NN cord-005453-4057qib7 6494 35 completely completely RB cord-005453-4057qib7 6494 36 but but CC cord-005453-4057qib7 6494 37 only only RB cord-005453-4057qib7 6494 38 one one CD cord-005453-4057qib7 6494 39 of of IN cord-005453-4057qib7 6494 40 the the DT cord-005453-4057qib7 6494 41 6 6 CD cord-005453-4057qib7 6494 42 patients patient NNS cord-005453-4057qib7 6494 43 in in IN cord-005453-4057qib7 6494 44 nephrotoxicity nephrotoxicity NNP cord-005453-4057qib7 6494 45 group group NN cord-005453-4057qib7 6494 46 responded respond VBD cord-005453-4057qib7 6494 47 and and CC cord-005453-4057qib7 6494 48 also also RB cord-005453-4057qib7 6494 49 3 3 CD cord-005453-4057qib7 6494 50 of of IN cord-005453-4057qib7 6494 51 the the DT cord-005453-4057qib7 6494 52 5 5 CD cord-005453-4057qib7 6494 53 patients patient NNS cord-005453-4057qib7 6494 54 in in IN cord-005453-4057qib7 6494 55 hepatoxicity hepatoxicity NNP cord-005453-4057qib7 6494 56 group group NN cord-005453-4057qib7 6494 57 responded respond VBD cord-005453-4057qib7 6494 58 . . . cord-005453-4057qib7 6495 1 The the DT cord-005453-4057qib7 6495 2 only only JJ cord-005453-4057qib7 6495 3 one one CD cord-005453-4057qib7 6495 4 patient patient NN cord-005453-4057qib7 6495 5 suffered suffer VBD cord-005453-4057qib7 6495 6 from from IN cord-005453-4057qib7 6495 7 autoimmune autoimmune JJ cord-005453-4057qib7 6495 8 thyroiditis thyroiditis NN cord-005453-4057qib7 6495 9 did do VBD cord-005453-4057qib7 6495 10 not not RB cord-005453-4057qib7 6495 11 respond respond VB cord-005453-4057qib7 6495 12 to to IN cord-005453-4057qib7 6495 13 conversion conversion NN cord-005453-4057qib7 6495 14 . . . cord-005453-4057qib7 6496 1 Conclusions conclusion NNS cord-005453-4057qib7 6496 2 : : : cord-005453-4057qib7 6497 1 In in IN cord-005453-4057qib7 6497 2 this this DT cord-005453-4057qib7 6497 3 study study NN cord-005453-4057qib7 6497 4 , , , cord-005453-4057qib7 6497 5 it -PRON- PRP cord-005453-4057qib7 6497 6 is be VBZ cord-005453-4057qib7 6497 7 obvious obvious JJ cord-005453-4057qib7 6497 8 that that IN cord-005453-4057qib7 6497 9 there there EX cord-005453-4057qib7 6497 10 are be VBP cord-005453-4057qib7 6497 11 response response NN cord-005453-4057qib7 6497 12 to to IN cord-005453-4057qib7 6497 13 conversion conversion NN cord-005453-4057qib7 6497 14 for for IN cord-005453-4057qib7 6497 15 some some DT cord-005453-4057qib7 6497 16 specific specific JJ cord-005453-4057qib7 6497 17 adverse adverse JJ cord-005453-4057qib7 6497 18 effects effect NNS cord-005453-4057qib7 6497 19 of of IN cord-005453-4057qib7 6497 20 CSA CSA NNP cord-005453-4057qib7 6497 21 and and CC cord-005453-4057qib7 6497 22 tacrolimus tacrolimus NNP cord-005453-4057qib7 6497 23 is be VBZ cord-005453-4057qib7 6497 24 a a DT cord-005453-4057qib7 6497 25 good good JJ cord-005453-4057qib7 6497 26 alternative alternative NN cord-005453-4057qib7 6497 27 for for IN cord-005453-4057qib7 6497 28 the the DT cord-005453-4057qib7 6497 29 patients patient NNS cord-005453-4057qib7 6497 30 who who WP cord-005453-4057qib7 6497 31 have have VBP cord-005453-4057qib7 6497 32 unproper unproper JJ cord-005453-4057qib7 6497 33 CSA CSA NNP cord-005453-4057qib7 6497 34 levels level NNS cord-005453-4057qib7 6497 35 . . . cord-005453-4057qib7 6498 1 Conversely conversely RB cord-005453-4057qib7 6498 2 , , , cord-005453-4057qib7 6498 3 the the DT cord-005453-4057qib7 6498 4 high high JJ cord-005453-4057qib7 6498 5 percentage percentage NN cord-005453-4057qib7 6498 6 ( ( -LRB- cord-005453-4057qib7 6498 7 % % NN cord-005453-4057qib7 6498 8 73 73 CD cord-005453-4057qib7 6498 9 ) ) -RRB- cord-005453-4057qib7 6498 10 of of IN cord-005453-4057qib7 6498 11 non non NNS cord-005453-4057qib7 6498 12 - - NNS cord-005453-4057qib7 6498 13 responders responder NNS cord-005453-4057qib7 6498 14 shows show VBZ cord-005453-4057qib7 6498 15 that that IN cord-005453-4057qib7 6498 16 it -PRON- PRP cord-005453-4057qib7 6498 17 is be VBZ cord-005453-4057qib7 6498 18 not not RB cord-005453-4057qib7 6498 19 feasible feasible JJ cord-005453-4057qib7 6498 20 to to TO cord-005453-4057qib7 6498 21 make make VB cord-005453-4057qib7 6498 22 a a DT cord-005453-4057qib7 6498 23 conversion conversion NN cord-005453-4057qib7 6498 24 to to TO cord-005453-4057qib7 6498 25 tacrolimus tacrolimus VB cord-005453-4057qib7 6498 26 for for IN cord-005453-4057qib7 6498 27 acute acute JJ cord-005453-4057qib7 6498 28 GvHD GvHD NNP cord-005453-4057qib7 6498 29 . . . cord-005453-4057qib7 6499 1 Disclosure disclosure NN cord-005453-4057qib7 6499 2 : : : cord-005453-4057qib7 6499 3 Nothing nothing NN cord-005453-4057qib7 6499 4 to to TO cord-005453-4057qib7 6499 5 declare declare VB cord-005453-4057qib7 6499 6 Background background NN cord-005453-4057qib7 6499 7 : : : cord-005453-4057qib7 6500 1 Capillary capillary JJ cord-005453-4057qib7 6500 2 leak leak NN cord-005453-4057qib7 6500 3 syndrome syndrome NN cord-005453-4057qib7 6500 4 is be VBZ cord-005453-4057qib7 6500 5 caused cause VBN cord-005453-4057qib7 6500 6 by by IN cord-005453-4057qib7 6500 7 the the DT cord-005453-4057qib7 6500 8 dysfunction dysfunction NN cord-005453-4057qib7 6500 9 of of IN cord-005453-4057qib7 6500 10 the the DT cord-005453-4057qib7 6500 11 vascular vascular JJ cord-005453-4057qib7 6500 12 endothelial endothelial JJ cord-005453-4057qib7 6500 13 cells cell NNS cord-005453-4057qib7 6500 14 , , , cord-005453-4057qib7 6500 15 and and CC cord-005453-4057qib7 6500 16 is be VBZ cord-005453-4057qib7 6500 17 characterized characterize VBN cord-005453-4057qib7 6500 18 by by IN cord-005453-4057qib7 6500 19 weight weight NN cord-005453-4057qib7 6500 20 gain gain NN cord-005453-4057qib7 6500 21 , , , cord-005453-4057qib7 6500 22 generalized generalize VBN cord-005453-4057qib7 6500 23 edemas edemas NN cord-005453-4057qib7 6500 24 , , , cord-005453-4057qib7 6500 25 unresponsive unresponsive JJ cord-005453-4057qib7 6500 26 to to IN cord-005453-4057qib7 6500 27 diuretic diuretic JJ cord-005453-4057qib7 6500 28 treatment treatment NN cord-005453-4057qib7 6500 29 , , , cord-005453-4057qib7 6500 30 and and CC cord-005453-4057qib7 6500 31 hypotension hypotension NN cord-005453-4057qib7 6500 32 . . . cord-005453-4057qib7 6501 1 It -PRON- PRP cord-005453-4057qib7 6501 2 usually usually RB cord-005453-4057qib7 6501 3 develops develop VBZ cord-005453-4057qib7 6501 4 in in IN cord-005453-4057qib7 6501 5 the the DT cord-005453-4057qib7 6501 6 first first JJ cord-005453-4057qib7 6501 7 15 15 CD cord-005453-4057qib7 6501 8 days day NNS cord-005453-4057qib7 6501 9 post post NN cord-005453-4057qib7 6502 1 HSCT.And HSCT.And NNP cord-005453-4057qib7 6503 1 it -PRON- PRP cord-005453-4057qib7 6503 2 is be VBZ cord-005453-4057qib7 6503 3 of of IN cord-005453-4057qib7 6503 4 great great JJ cord-005453-4057qib7 6503 5 difficuty difficuty NNS cord-005453-4057qib7 6503 6 to to TO cord-005453-4057qib7 6503 7 distinguish distinguish VB cord-005453-4057qib7 6503 8 from from IN cord-005453-4057qib7 6503 9 other other JJ cord-005453-4057qib7 6503 10 complications complication NNS cord-005453-4057qib7 6503 11 which which WDT cord-005453-4057qib7 6503 12 are be VBP cord-005453-4057qib7 6503 13 occured occur VBN cord-005453-4057qib7 6503 14 post post VB cord-005453-4057qib7 6503 15 the the DT cord-005453-4057qib7 6503 16 allo allo NN cord-005453-4057qib7 6503 17 - - HYPH cord-005453-4057qib7 6503 18 HSCT HSCT NNP cord-005453-4057qib7 6503 19 . . . cord-005453-4057qib7 6504 1 To to TO cord-005453-4057qib7 6504 2 diagnose diagnose VB cord-005453-4057qib7 6504 3 this this DT cord-005453-4057qib7 6504 4 complication complication NN cord-005453-4057qib7 6504 5 at at IN cord-005453-4057qib7 6504 6 the the DT cord-005453-4057qib7 6504 7 early early JJ cord-005453-4057qib7 6504 8 stage stage NN cord-005453-4057qib7 6504 9 , , , cord-005453-4057qib7 6504 10 it -PRON- PRP cord-005453-4057qib7 6504 11 is be VBZ cord-005453-4057qib7 6504 12 very very RB cord-005453-4057qib7 6504 13 difficulty difficulty NN cord-005453-4057qib7 6504 14 . . . cord-005453-4057qib7 6505 1 Methods method NNS cord-005453-4057qib7 6505 2 : : : cord-005453-4057qib7 6506 1 A a DT cord-005453-4057qib7 6506 2 34-year 34-year JJ cord-005453-4057qib7 6506 3 - - HYPH cord-005453-4057qib7 6506 4 old old JJ cord-005453-4057qib7 6506 5 man man NN cord-005453-4057qib7 6506 6 was be VBD cord-005453-4057qib7 6506 7 admitted admit VBN cord-005453-4057qib7 6506 8 to to IN cord-005453-4057qib7 6506 9 Ningbo Ningbo NNP cord-005453-4057qib7 6506 10 first first JJ cord-005453-4057qib7 6506 11 hospital hospital NN cord-005453-4057qib7 6506 12 for for IN cord-005453-4057qib7 6506 13 its -PRON- PRP$ cord-005453-4057qib7 6506 14 abnormal abnormal JJ cord-005453-4057qib7 6506 15 in in IN cord-005453-4057qib7 6506 16 the the DT cord-005453-4057qib7 6506 17 peripheral peripheral JJ cord-005453-4057qib7 6506 18 blood blood NN cord-005453-4057qib7 6506 19 .He .He . cord-005453-4057qib7 6506 20 was be VBD cord-005453-4057qib7 6506 21 diagnosed diagnose VBN cord-005453-4057qib7 6506 22 with with IN cord-005453-4057qib7 6506 23 AML AML NNP cord-005453-4057qib7 6506 24 - - HYPH cord-005453-4057qib7 6506 25 M5 M5 NNP cord-005453-4057qib7 6506 26 by by IN cord-005453-4057qib7 6506 27 the the DT cord-005453-4057qib7 6506 28 classical classical JJ cord-005453-4057qib7 6506 29 morphology morphology NN cord-005453-4057qib7 6506 30 and and CC cord-005453-4057qib7 6506 31 immunophenotype immunophenotype NN cord-005453-4057qib7 6506 32 . . . cord-005453-4057qib7 6507 1 Cytogenetic cytogenetic JJ cord-005453-4057qib7 6507 2 evaluation evaluation NN cord-005453-4057qib7 6507 3 showed show VBD cord-005453-4057qib7 6507 4 a a DT cord-005453-4057qib7 6507 5 normal normal JJ cord-005453-4057qib7 6507 6 46 46 CD cord-005453-4057qib7 6507 7 , , , cord-005453-4057qib7 6507 8 XY(20).The XY(20).The NNP cord-005453-4057qib7 6507 9 patient patient NN cord-005453-4057qib7 6507 10 achieved achieve VBD cord-005453-4057qib7 6507 11 CR CR NNP cord-005453-4057qib7 6507 12 with with IN cord-005453-4057qib7 6507 13 induction induction NN cord-005453-4057qib7 6507 14 therapy therapy NN cord-005453-4057qib7 6507 15 including include VBG cord-005453-4057qib7 6507 16 Idarubicin Idarubicin NNP cord-005453-4057qib7 6507 17 , , , cord-005453-4057qib7 6507 18 Cytarabine Cytarabine NNP cord-005453-4057qib7 6507 19 and and CC cord-005453-4057qib7 6507 20 Etoposide Etoposide NNP cord-005453-4057qib7 6507 21 . . . cord-005453-4057qib7 6508 1 After after IN cord-005453-4057qib7 6508 2 consolidation consolidation NN cord-005453-4057qib7 6508 3 therapy therapy NN cord-005453-4057qib7 6508 4 , , , cord-005453-4057qib7 6508 5 an an DT cord-005453-4057qib7 6508 6 allo allo NN cord-005453-4057qib7 6508 7 - - HYPH cord-005453-4057qib7 6508 8 HSCT HSCT NNP cord-005453-4057qib7 6508 9 from from IN cord-005453-4057qib7 6508 10 HLA HLA NNP cord-005453-4057qib7 6508 11 identical identical JJ cord-005453-4057qib7 6508 12 related relate VBN cord-005453-4057qib7 6508 13 dornor(33-year dornor(33-year JJ cord-005453-4057qib7 6508 14 - - HYPH cord-005453-4057qib7 6508 15 old old JJ cord-005453-4057qib7 6508 16 male male NN cord-005453-4057qib7 6508 17 , , , cord-005453-4057qib7 6508 18 donorrecipient donorrecipient NN cord-005453-4057qib7 6508 19 matched match VBN cord-005453-4057qib7 6508 20 by by IN cord-005453-4057qib7 6508 21 high high JJ cord-005453-4057qib7 6508 22 resolution resolution NN cord-005453-4057qib7 6508 23 HLA HLA NNP cord-005453-4057qib7 6508 24 typing type VBG cord-005453-4057qib7 6508 25 at at IN cord-005453-4057qib7 6508 26 HLAA HLAA NNP cord-005453-4057qib7 6508 27 , , , cord-005453-4057qib7 6508 28 -B -b ADD cord-005453-4057qib7 6508 29 , , , cord-005453-4057qib7 6508 30 -C -C VBZ cord-005453-4057qib7 6508 31 , , , cord-005453-4057qib7 6508 32 DRB1 DRB1 NNP cord-005453-4057qib7 6508 33 , , , cord-005453-4057qib7 6508 34 and and CC cord-005453-4057qib7 6508 35 DQB1 DQB1 NNP cord-005453-4057qib7 6508 36 , , , cord-005453-4057qib7 6508 37 10/10 10/10 CD cord-005453-4057qib7 6508 38 matches match NNS cord-005453-4057qib7 6508 39 ) ) -RRB- cord-005453-4057qib7 6508 40 was be VBD cord-005453-4057qib7 6508 41 performed perform VBN cord-005453-4057qib7 6508 42 . . . cord-005453-4057qib7 6509 1 The the DT cord-005453-4057qib7 6509 2 recipient recipient NN cord-005453-4057qib7 6509 3 received receive VBD cord-005453-4057qib7 6509 4 conditioning conditioning NN cord-005453-4057qib7 6509 5 with with IN cord-005453-4057qib7 6509 6 busulfan busulfan NN cord-005453-4057qib7 6509 7 , , , cord-005453-4057qib7 6509 8 4 4 CD cord-005453-4057qib7 6509 9 mg mg NNP cord-005453-4057qib7 6509 10 / / SYM cord-005453-4057qib7 6509 11 kg kg NNP cord-005453-4057qib7 6509 12 / / SYM cord-005453-4057qib7 6509 13 day day NN cord-005453-4057qib7 6509 14 injection injection NN cord-005453-4057qib7 6509 15 for for IN cord-005453-4057qib7 6509 16 3 3 CD cord-005453-4057qib7 6509 17 days day NNS cord-005453-4057qib7 6509 18 ; ; : cord-005453-4057qib7 6509 19 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 6509 20 , , , cord-005453-4057qib7 6509 21 50 50 CD cord-005453-4057qib7 6509 22 mg mg NNP cord-005453-4057qib7 6509 23 / / SYM cord-005453-4057qib7 6509 24 kg kg NNP cord-005453-4057qib7 6509 25 / / SYM cord-005453-4057qib7 6509 26 day day NN cord-005453-4057qib7 6509 27 injection injection NN cord-005453-4057qib7 6509 28 for for IN cord-005453-4057qib7 6509 29 2 2 CD cord-005453-4057qib7 6509 30 days day NNS cord-005453-4057qib7 6509 31 ; ; : cord-005453-4057qib7 6509 32 cytarabine cytarabine RB cord-005453-4057qib7 6509 33 , , , cord-005453-4057qib7 6509 34 2 2 CD cord-005453-4057qib7 6509 35 g g NN cord-005453-4057qib7 6509 36 / / SYM cord-005453-4057qib7 6509 37 m2 m2 NNP cord-005453-4057qib7 6509 38 / / SYM cord-005453-4057qib7 6509 39 day day NN cord-005453-4057qib7 6509 40 injection injection NN cord-005453-4057qib7 6509 41 for for IN cord-005453-4057qib7 6509 42 1 1 CD cord-005453-4057qib7 6509 43 day day NN cord-005453-4057qib7 6509 44 ; ; : cord-005453-4057qib7 6509 45 semustine semustine NNP cord-005453-4057qib7 6509 46 , , , cord-005453-4057qib7 6510 1 250 250 CD cord-005453-4057qib7 6510 2 mg mg NNP cord-005453-4057qib7 6510 3 / / SYM cord-005453-4057qib7 6510 4 m2 m2 NNP cord-005453-4057qib7 6510 5 / / SYM cord-005453-4057qib7 6510 6 day day NN cord-005453-4057qib7 6510 7 orally orally RB cord-005453-4057qib7 6510 8 for for IN cord-005453-4057qib7 6510 9 1day 1day CD cord-005453-4057qib7 6510 10 ; ; : cord-005453-4057qib7 6510 11 Donor donor NN cord-005453-4057qib7 6510 12 peripheral peripheral JJ cord-005453-4057qib7 6510 13 blood blood NN cord-005453-4057qib7 6510 14 stem stem NN cord-005453-4057qib7 6510 15 cells cell NNS cord-005453-4057qib7 6510 16 ( ( -LRB- cord-005453-4057qib7 6510 17 PBSC PBSC NNP cord-005453-4057qib7 6510 18 : : : cord-005453-4057qib7 6510 19 MNC MNC NNP cord-005453-4057qib7 6510 20 : : : cord-005453-4057qib7 6511 1 6.43×109 6.43×109 LS cord-005453-4057qib7 6511 2 / / SYM cord-005453-4057qib7 6511 3 L L NNP cord-005453-4057qib7 6511 4 , , , cord-005453-4057qib7 6511 5 CD34+:4.05×106 CD34+:4.05×106 NNP cord-005453-4057qib7 6511 6 / / SYM cord-005453-4057qib7 6511 7 L L NNP cord-005453-4057qib7 6511 8 ) ) -RRB- cord-005453-4057qib7 6511 9 were be VBD cord-005453-4057qib7 6511 10 mobilized mobilize VBN cord-005453-4057qib7 6511 11 , , , cord-005453-4057qib7 6511 12 pheresed pheresed JJ cord-005453-4057qib7 6511 13 and and CC cord-005453-4057qib7 6511 14 administered administer VBN cord-005453-4057qib7 6511 15 to to IN cord-005453-4057qib7 6511 16 the the DT cord-005453-4057qib7 6511 17 recipient recipient NN cord-005453-4057qib7 6511 18 . . . cord-005453-4057qib7 6512 1 GVHD GVHD NNP cord-005453-4057qib7 6512 2 prophylaxis prophylaxis NN cord-005453-4057qib7 6512 3 consisted consist VBD cord-005453-4057qib7 6512 4 of of IN cord-005453-4057qib7 6512 5 traditional traditional JJ cord-005453-4057qib7 6512 6 cyclosporine cyclosporine JJ cord-005453-4057qib7 6512 7 , , , cord-005453-4057qib7 6512 8 short short JJ cord-005453-4057qib7 6512 9 - - HYPH cord-005453-4057qib7 6512 10 course course NN cord-005453-4057qib7 6512 11 methotrexate methotrexate NNP cord-005453-4057qib7 6512 12 ( ( -LRB- cord-005453-4057qib7 6512 13 15 15 CD cord-005453-4057qib7 6512 14 mg/ mg/ NN cord-005453-4057qib7 6512 15 m2 m2 NNP cord-005453-4057qib7 6512 16 at at IN cord-005453-4057qib7 6512 17 day day NN cord-005453-4057qib7 6512 18 +1 +1 NFP cord-005453-4057qib7 6512 19 , , , cord-005453-4057qib7 6512 20 10 10 CD cord-005453-4057qib7 6512 21 mg mg NNP cord-005453-4057qib7 6512 22 / / SYM cord-005453-4057qib7 6512 23 m2 m2 NNP cord-005453-4057qib7 6512 24 at at IN cord-005453-4057qib7 6512 25 days day NNS cord-005453-4057qib7 6512 26 +3 +3 NNP cord-005453-4057qib7 6512 27 , , , cord-005453-4057qib7 6512 28 +6 +6 NNP cord-005453-4057qib7 6512 29 , , , cord-005453-4057qib7 6512 30 and and CC cord-005453-4057qib7 6512 31 +11 +11 CD cord-005453-4057qib7 6512 32 ) ) -RRB- cord-005453-4057qib7 6512 33 and and CC cord-005453-4057qib7 6512 34 Cyclosporin Cyclosporin NNP cord-005453-4057qib7 6512 35 A a DT cord-005453-4057qib7 6512 36 injection injection NN cord-005453-4057qib7 6512 37 5mg 5mg NN cord-005453-4057qib7 6512 38 / / SYM cord-005453-4057qib7 6512 39 kg kg NNP cord-005453-4057qib7 6512 40 qer qer NNP cord-005453-4057qib7 6512 41 day day NNP cord-005453-4057qib7 6513 1 was be VBD cord-005453-4057qib7 6513 2 mot mot NNP cord-005453-4057qib7 6513 3 reduced reduce VBN cord-005453-4057qib7 6513 4 untill untill IN cord-005453-4057qib7 6513 5 the the DT cord-005453-4057qib7 6513 6 hematopoietic hematopoietic NN cord-005453-4057qib7 6513 7 reconstitute reconstitute VBP cord-005453-4057qib7 6513 8 sucessfully sucessfully RB cord-005453-4057qib7 6513 9 . . . cord-005453-4057qib7 6514 1 On on IN cord-005453-4057qib7 6514 2 day day NN cord-005453-4057qib7 6514 3 +19 +19 CD cord-005453-4057qib7 6514 4 , , , cord-005453-4057qib7 6514 5 complete complete JJ cord-005453-4057qib7 6514 6 donor donor NN cord-005453-4057qib7 6514 7 chimerism chimerism NN cord-005453-4057qib7 6514 8 was be VBD cord-005453-4057qib7 6514 9 acheieved acheieved JJ cord-005453-4057qib7 6514 10 . . . cord-005453-4057qib7 6515 1 The the DT cord-005453-4057qib7 6515 2 CsA csa NN cord-005453-4057qib7 6515 3 was be VBD cord-005453-4057qib7 6515 4 gradually gradually RB cord-005453-4057qib7 6515 5 reduced reduce VBN cord-005453-4057qib7 6515 6 and and CC cord-005453-4057qib7 6515 7 tapered tapered JJ cord-005453-4057qib7 6515 8 . . . cord-005453-4057qib7 6516 1 On on IN cord-005453-4057qib7 6516 2 day day NN cord-005453-4057qib7 6516 3 +150,the +150,the JJS cord-005453-4057qib7 6516 4 patients patient NNS cord-005453-4057qib7 6516 5 was be VBD cord-005453-4057qib7 6516 6 manifested manifest VBN cord-005453-4057qib7 6516 7 with with IN cord-005453-4057qib7 6516 8 increasing increase VBG cord-005453-4057qib7 6516 9 in in IN cord-005453-4057qib7 6516 10 the the DT cord-005453-4057qib7 6516 11 time time NN cord-005453-4057qib7 6516 12 and and CC cord-005453-4057qib7 6516 13 volume volume NN cord-005453-4057qib7 6516 14 of of IN cord-005453-4057qib7 6516 15 the the DT cord-005453-4057qib7 6516 16 faeces faece NNS cord-005453-4057qib7 6516 17 , , , cord-005453-4057qib7 6516 18 he -PRON- PRP cord-005453-4057qib7 6516 19 was be VBD cord-005453-4057qib7 6516 20 diagnosed diagnose VBN cord-005453-4057qib7 6516 21 with with IN cord-005453-4057qib7 6516 22 II ii CD cord-005453-4057qib7 6516 23 ° ° NN cord-005453-4057qib7 6516 24 GVHD GVHD NNP cord-005453-4057qib7 6517 1 ( ( -LRB- cord-005453-4057qib7 6517 2 gut).The gut).The NNP cord-005453-4057qib7 6517 3 standarded standarde VBD cord-005453-4057qib7 6517 4 does do VBZ cord-005453-4057qib7 6517 5 of of IN cord-005453-4057qib7 6517 6 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6517 7 drug drug NN cord-005453-4057qib7 6517 8 including include VBG cord-005453-4057qib7 6517 9 methylprednisolone methylprednisolone NN cord-005453-4057qib7 6517 10 and and CC cord-005453-4057qib7 6517 11 Cyclosporin Cyclosporin NNP cord-005453-4057qib7 6517 12 A A NNP cord-005453-4057qib7 6517 13 was be VBD cord-005453-4057qib7 6517 14 administrated administrate VBN cord-005453-4057qib7 6517 15 . . . cord-005453-4057qib7 6518 1 The the DT cord-005453-4057qib7 6518 2 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6518 3 drug drug NN cord-005453-4057qib7 6518 4 was be VBD cord-005453-4057qib7 6518 5 gradually gradually RB cord-005453-4057qib7 6518 6 reduced reduce VBN cord-005453-4057qib7 6518 7 when when WRB cord-005453-4057qib7 6518 8 the the DT cord-005453-4057qib7 6518 9 GVHD GVHD NNP cord-005453-4057qib7 6518 10 was be VBD cord-005453-4057qib7 6518 11 controlled control VBN cord-005453-4057qib7 6518 12 . . . cord-005453-4057qib7 6519 1 On on IN cord-005453-4057qib7 6519 2 day+271,the day+271,the DT cord-005453-4057qib7 6519 3 patient patient NN cord-005453-4057qib7 6519 4 felt feel VBD cord-005453-4057qib7 6519 5 distress distress NN cord-005453-4057qib7 6519 6 and and CC cord-005453-4057qib7 6519 7 the the DT cord-005453-4057qib7 6519 8 distress distress NN cord-005453-4057qib7 6519 9 was be VBD cord-005453-4057qib7 6519 10 not not RB cord-005453-4057qib7 6519 11 related relate VBN cord-005453-4057qib7 6519 12 to to IN cord-005453-4057qib7 6519 13 with with IN cord-005453-4057qib7 6519 14 the the DT cord-005453-4057qib7 6519 15 exercise exercise NN cord-005453-4057qib7 6519 16 , , , cord-005453-4057qib7 6519 17 the the DT cord-005453-4057qib7 6519 18 temperature temperature NN cord-005453-4057qib7 6519 19 was be VBD cord-005453-4057qib7 6519 20 normal normal JJ cord-005453-4057qib7 6519 21 , , , cord-005453-4057qib7 6519 22 and and CC cord-005453-4057qib7 6519 23 he -PRON- PRP cord-005453-4057qib7 6519 24 did do VBD cord-005453-4057qib7 6519 25 not not RB cord-005453-4057qib7 6519 26 gain gain VB cord-005453-4057qib7 6519 27 weight weight NN cord-005453-4057qib7 6519 28 . . . cord-005453-4057qib7 6520 1 There there EX cord-005453-4057qib7 6520 2 was be VBD cord-005453-4057qib7 6520 3 no no DT cord-005453-4057qib7 6520 4 edema edema NN cord-005453-4057qib7 6520 5 in in IN cord-005453-4057qib7 6520 6 the the DT cord-005453-4057qib7 6520 7 body body NN cord-005453-4057qib7 6520 8 . . . cord-005453-4057qib7 6521 1 Laboratory laboratory NN cord-005453-4057qib7 6521 2 test test NN cord-005453-4057qib7 6521 3 including include VBG cord-005453-4057qib7 6521 4 routine routine JJ cord-005453-4057qib7 6521 5 blood blood NN cord-005453-4057qib7 6521 6 test test NN cord-005453-4057qib7 6521 7 , , , cord-005453-4057qib7 6521 8 C c NN cord-005453-4057qib7 6521 9 - - HYPH cord-005453-4057qib7 6521 10 reactive reactive JJ cord-005453-4057qib7 6521 11 protein protein NN cord-005453-4057qib7 6521 12 , , , cord-005453-4057qib7 6521 13 procalcitonin procalcitonin NNS cord-005453-4057qib7 6521 14 , , , cord-005453-4057qib7 6521 15 blood blood NN cord-005453-4057qib7 6521 16 gas gas NN cord-005453-4057qib7 6521 17 analysis analysis NN cord-005453-4057qib7 6521 18 , , , cord-005453-4057qib7 6521 19 CMVDNA CMVDNA NNP cord-005453-4057qib7 6521 20 , , , cord-005453-4057qib7 6521 21 EBVDNA EBVDNA NNP cord-005453-4057qib7 6521 22 was be VBD cord-005453-4057qib7 6521 23 normal normal JJ cord-005453-4057qib7 6521 24 . . . cord-005453-4057qib7 6522 1 The the DT cord-005453-4057qib7 6522 2 CT CT NNP cord-005453-4057qib7 6522 3 scan scan NN cord-005453-4057qib7 6522 4 shows show VBZ cord-005453-4057qib7 6522 5 that that IN cord-005453-4057qib7 6522 6 1the 1the DT cord-005453-4057qib7 6522 7 pleural pleural NN cord-005453-4057qib7 6522 8 is be VBZ cord-005453-4057qib7 6522 9 filled fill VBN cord-005453-4057qib7 6522 10 up up RP cord-005453-4057qib7 6522 11 with with IN cord-005453-4057qib7 6522 12 water water NN cord-005453-4057qib7 6522 13 , , , cord-005453-4057qib7 6522 14 and and CC cord-005453-4057qib7 6522 15 could could MD cord-005453-4057qib7 6522 16 not not RB cord-005453-4057qib7 6522 17 be be VB cord-005453-4057qib7 6522 18 enlarged enlarge VBN cord-005453-4057qib7 6522 19 promptly,2There promptly,2there NN cord-005453-4057qib7 6522 20 is be VBZ cord-005453-4057qib7 6522 21 pericardial pericardial JJ cord-005453-4057qib7 6522 22 effusion effusion NN cord-005453-4057qib7 6522 23 in in IN cord-005453-4057qib7 6522 24 the the DT cord-005453-4057qib7 6522 25 body body NN cord-005453-4057qib7 6522 26 . . . cord-005453-4057qib7 6523 1 Pulmonary pulmonary JJ cord-005453-4057qib7 6523 2 function function NN cord-005453-4057qib7 6523 3 test test NN cord-005453-4057qib7 6523 4 shows show VBZ cord-005453-4057qib7 6523 5 that that IN cord-005453-4057qib7 6523 6 1 1 CD cord-005453-4057qib7 6523 7 reduced reduce VBN cord-005453-4057qib7 6523 8 function function NN cord-005453-4057qib7 6523 9 in in IN cord-005453-4057qib7 6523 10 ventilation ventilation NN cord-005453-4057qib7 6523 11 and and CC cord-005453-4057qib7 6523 12 diffusion diffusion NN cord-005453-4057qib7 6523 13 fuction fuction NN cord-005453-4057qib7 6523 14 . . . cord-005453-4057qib7 6524 1 The the DT cord-005453-4057qib7 6524 2 laboratory laboratory NN cord-005453-4057qib7 6524 3 test test NN cord-005453-4057qib7 6524 4 of of IN cord-005453-4057qib7 6524 5 the the DT cord-005453-4057qib7 6524 6 pleural pleural JJ cord-005453-4057qib7 6524 7 effusion effusion NN cord-005453-4057qib7 6524 8 was be VBD cord-005453-4057qib7 6524 9 normal normal JJ cord-005453-4057qib7 6524 10 , , , cord-005453-4057qib7 6524 11 the the DT cord-005453-4057qib7 6524 12 blast blast NN cord-005453-4057qib7 6524 13 cell cell NN cord-005453-4057qib7 6524 14 was be VBD cord-005453-4057qib7 6524 15 not not RB cord-005453-4057qib7 6524 16 detected detect VBN cord-005453-4057qib7 6524 17 in in IN cord-005453-4057qib7 6524 18 the the DT cord-005453-4057qib7 6524 19 pleural pleural JJ cord-005453-4057qib7 6524 20 effusion effusion NN cord-005453-4057qib7 6524 21 , , . cord-005453-4057qib7 6525 1 the the DT cord-005453-4057qib7 6525 2 CD34 CD34 NNP cord-005453-4057qib7 6525 3 + + CC cord-005453-4057qib7 6525 4 cell cell NN cord-005453-4057qib7 6525 5 count count NN cord-005453-4057qib7 6525 6 was be VBD cord-005453-4057qib7 6525 7 below below IN cord-005453-4057qib7 6525 8 the the DT cord-005453-4057qib7 6525 9 dectable dectable JJ cord-005453-4057qib7 6525 10 level level NN cord-005453-4057qib7 6525 11 , , , cord-005453-4057qib7 6525 12 the the DT cord-005453-4057qib7 6525 13 next next JJ cord-005453-4057qib7 6525 14 generation generation NN cord-005453-4057qib7 6525 15 sequencing sequence VBG cord-005453-4057qib7 6525 16 for for IN cord-005453-4057qib7 6525 17 minimal minimal JJ cord-005453-4057qib7 6525 18 residual residual JJ cord-005453-4057qib7 6525 19 disease disease NN cord-005453-4057qib7 6525 20 shows show VBZ cord-005453-4057qib7 6525 21 that that IN cord-005453-4057qib7 6525 22 there there EX cord-005453-4057qib7 6525 23 was be VBD cord-005453-4057qib7 6525 24 no no DT cord-005453-4057qib7 6525 25 gene gene NN cord-005453-4057qib7 6525 26 mutation mutation NN cord-005453-4057qib7 6525 27 .Thus .Thus . cord-005453-4057qib7 6526 1 , , , cord-005453-4057qib7 6526 2 post post JJ cord-005453-4057qib7 6526 3 capillary capillary JJ cord-005453-4057qib7 6526 4 leak leak NN cord-005453-4057qib7 6526 5 syndrome syndrome NN cord-005453-4057qib7 6526 6 was be VBD cord-005453-4057qib7 6526 7 considered consider VBN cord-005453-4057qib7 6526 8 .Sirolimus .sirolimus NN cord-005453-4057qib7 6526 9 was be VBD cord-005453-4057qib7 6526 10 adopted adopt VBN cord-005453-4057qib7 6526 11 and and CC cord-005453-4057qib7 6526 12 taken take VBN cord-005453-4057qib7 6526 13 the the DT cord-005453-4057qib7 6526 14 place place NN cord-005453-4057qib7 6526 15 of of IN cord-005453-4057qib7 6526 16 Cyclosporin Cyclosporin NNP cord-005453-4057qib7 6526 17 A A NNP cord-005453-4057qib7 6526 18 , , , cord-005453-4057qib7 6526 19 Immunoglobulin Immunoglobulin NNP cord-005453-4057qib7 6526 20 was be VBD cord-005453-4057qib7 6526 21 adminstrated adminstrate VBN cord-005453-4057qib7 6526 22 to to TO cord-005453-4057qib7 6526 23 reduce reduce VB cord-005453-4057qib7 6526 24 the the DT cord-005453-4057qib7 6526 25 edema edema NN cord-005453-4057qib7 6526 26 . . . cord-005453-4057qib7 6527 1 Results result NNS cord-005453-4057qib7 6527 2 : : : cord-005453-4057qib7 6528 1 Taking take VBG cord-005453-4057qib7 6528 2 together together RB cord-005453-4057qib7 6528 3 comprehensively comprehensively RB cord-005453-4057qib7 6528 4 , , , cord-005453-4057qib7 6528 5 the the DT cord-005453-4057qib7 6528 6 effusion effusion NN cord-005453-4057qib7 6528 7 in in IN cord-005453-4057qib7 6528 8 the the DT cord-005453-4057qib7 6528 9 pleural pleural JJ cord-005453-4057qib7 6528 10 and and CC cord-005453-4057qib7 6528 11 cardiac cardiac NN cord-005453-4057qib7 6528 12 was be VBD cord-005453-4057qib7 6528 13 absorbed absorb VBN cord-005453-4057qib7 6528 14 well well RB cord-005453-4057qib7 6528 15 . . . cord-005453-4057qib7 6529 1 Conclusions conclusion NNS cord-005453-4057qib7 6529 2 : : : cord-005453-4057qib7 6530 1 Occurance occurance IN cord-005453-4057qib7 6530 2 of of IN cord-005453-4057qib7 6530 3 capillary capillary JJ cord-005453-4057qib7 6530 4 leak leak NN cord-005453-4057qib7 6530 5 syndrome syndrome NN cord-005453-4057qib7 6530 6 is be VBZ cord-005453-4057qib7 6530 7 rare rare JJ cord-005453-4057qib7 6530 8 , , , cord-005453-4057qib7 6530 9 there there EX cord-005453-4057qib7 6530 10 is be VBZ cord-005453-4057qib7 6530 11 limited limited JJ cord-005453-4057qib7 6530 12 data datum NNS cord-005453-4057qib7 6530 13 about about IN cord-005453-4057qib7 6530 14 capillary capillary JJ cord-005453-4057qib7 6530 15 leak leak NN cord-005453-4057qib7 6530 16 syndrome syndrome NN cord-005453-4057qib7 6530 17 . . . cord-005453-4057qib7 6531 1 Comprehensively comprehensively RB cord-005453-4057qib7 6531 2 , , , cord-005453-4057qib7 6531 3 the the DT cord-005453-4057qib7 6531 4 mechanism mechanism NN cord-005453-4057qib7 6531 5 of of IN cord-005453-4057qib7 6531 6 CLS CLS NNP cord-005453-4057qib7 6531 7 has have VBZ cord-005453-4057qib7 6531 8 not not RB cord-005453-4057qib7 6531 9 been be VBN cord-005453-4057qib7 6531 10 totally totally RB cord-005453-4057qib7 6531 11 identified identify VBN cord-005453-4057qib7 6531 12 . . . cord-005453-4057qib7 6532 1 And and CC cord-005453-4057qib7 6532 2 there there EX cord-005453-4057qib7 6532 3 is be VBZ cord-005453-4057qib7 6532 4 no no DT cord-005453-4057qib7 6532 5 standard standard JJ cord-005453-4057qib7 6532 6 treatment treatment NN cord-005453-4057qib7 6532 7 to to TO cord-005453-4057qib7 6532 8 treat treat VB cord-005453-4057qib7 6532 9 the the DT cord-005453-4057qib7 6532 10 complication complication NN cord-005453-4057qib7 6532 11 . . . cord-005453-4057qib7 6533 1 At at IN cord-005453-4057qib7 6533 2 present present NN cord-005453-4057qib7 6533 3 , , , cord-005453-4057qib7 6533 4 the the DT cord-005453-4057qib7 6533 5 CLS CLS NNP cord-005453-4057qib7 6533 6 of of IN cord-005453-4057qib7 6533 7 this this DT cord-005453-4057qib7 6533 8 patient patient NN cord-005453-4057qib7 6533 9 was be VBD cord-005453-4057qib7 6533 10 absorbed absorb VBN cord-005453-4057qib7 6533 11 well well RB cord-005453-4057qib7 6533 12 by by IN cord-005453-4057qib7 6533 13 administrating administrate VBG cord-005453-4057qib7 6533 14 Sirolimus Sirolimus NNP cord-005453-4057qib7 6533 15 , , , cord-005453-4057qib7 6533 16 closely closely RB cord-005453-4057qib7 6533 17 followup followup NN cord-005453-4057qib7 6533 18 is be VBZ cord-005453-4057qib7 6533 19 needed need VBN cord-005453-4057qib7 6533 20 . . . cord-005453-4057qib7 6534 1 Disclosure disclosure NN cord-005453-4057qib7 6534 2 : : : cord-005453-4057qib7 6534 3 Nothing nothing NN cord-005453-4057qib7 6534 4 to to TO cord-005453-4057qib7 6534 5 declare declare VB cord-005453-4057qib7 6534 6 Graft graft NN cord-005453-4057qib7 6534 7 - - HYPH cord-005453-4057qib7 6534 8 versus versus IN cord-005453-4057qib7 6534 9 - - HYPH cord-005453-4057qib7 6534 10 host host NN cord-005453-4057qib7 6534 11 diseasepreclinical diseasepreclinical JJ cord-005453-4057qib7 6534 12 and and CC cord-005453-4057qib7 6534 13 animal animal NN cord-005453-4057qib7 6534 14 models model NNS cord-005453-4057qib7 6535 1 P295 P295 `` cord-005453-4057qib7 6535 2 Short short JJ cord-005453-4057qib7 6535 3 - - HYPH cord-005453-4057qib7 6535 4 term term NN cord-005453-4057qib7 6535 5 KRP203 krp203 NN cord-005453-4057qib7 6535 6 and and CC cord-005453-4057qib7 6535 7 posttransplant posttransplant JJ cord-005453-4057qib7 6535 8 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 6535 9 for for IN cord-005453-4057qib7 6535 10 graft graft NN cord-005453-4057qib7 6535 11 - - HYPH cord-005453-4057qib7 6535 12 versus versus IN cord-005453-4057qib7 6535 13 - - HYPH cord-005453-4057qib7 6535 14 host host NN cord-005453-4057qib7 6535 15 disease disease NN cord-005453-4057qib7 6535 16 prophylaxis prophylaxis NN cord-005453-4057qib7 6535 17 Emi Emi NNP cord-005453-4057qib7 6535 18 Yokoyama Yokoyama NNP cord-005453-4057qib7 6535 19 1 1 CD cord-005453-4057qib7 6535 20 , , , cord-005453-4057qib7 6535 21 Daigo Daigo NNP cord-005453-4057qib7 6535 22 Hashimoto Hashimoto NNP cord-005453-4057qib7 6535 23 1 1 CD cord-005453-4057qib7 6535 24 , , , cord-005453-4057qib7 6535 25 Takahide Takahide NNP cord-005453-4057qib7 6535 26 Ara Ara NNP cord-005453-4057qib7 6535 27 1 1 CD cord-005453-4057qib7 6535 28 , , , cord-005453-4057qib7 6535 29 Eko Eko NNP cord-005453-4057qib7 6535 30 Hayase Hayase NNP cord-005453-4057qib7 6535 31 1 1 CD cord-005453-4057qib7 6535 32 , , , cord-005453-4057qib7 6536 1 Takanori Takanori NNP cord-005453-4057qib7 6536 2 Teshima Teshima NNP cord-005453-4057qib7 6536 3 1 1 CD cord-005453-4057qib7 6536 4 1 1 CD cord-005453-4057qib7 6536 5 Hokkaido Hokkaido NNP cord-005453-4057qib7 6536 6 University University NNP cord-005453-4057qib7 6536 7 Faculty Faculty NNP cord-005453-4057qib7 6536 8 of of IN cord-005453-4057qib7 6536 9 Medicine Medicine NNP cord-005453-4057qib7 6536 10 , , , cord-005453-4057qib7 6536 11 Hematology Hematology NNP cord-005453-4057qib7 6536 12 , , , cord-005453-4057qib7 6536 13 Sapporo Sapporo NNP cord-005453-4057qib7 6536 14 , , , cord-005453-4057qib7 6536 15 Japan Japan NNP cord-005453-4057qib7 6536 16 Background Background NNP cord-005453-4057qib7 6536 17 : : : cord-005453-4057qib7 6536 18 Post post JJ cord-005453-4057qib7 6536 19 - - JJ cord-005453-4057qib7 6536 20 transplant transplant JJ cord-005453-4057qib7 6536 21 high high JJ cord-005453-4057qib7 6536 22 - - HYPH cord-005453-4057qib7 6536 23 dose dose NN cord-005453-4057qib7 6536 24 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 6536 25 ( ( -LRB- cord-005453-4057qib7 6536 26 PTCY PTCY NNP cord-005453-4057qib7 6536 27 ) ) -RRB- cord-005453-4057qib7 6536 28 in in IN cord-005453-4057qib7 6536 29 combination combination NN cord-005453-4057qib7 6536 30 with with IN cord-005453-4057qib7 6536 31 other other JJ cord-005453-4057qib7 6536 32 immunosuppressants immunosuppressant NNS cord-005453-4057qib7 6536 33 such such JJ cord-005453-4057qib7 6536 34 as as IN cord-005453-4057qib7 6536 35 calcineurin calcineurin NN cord-005453-4057qib7 6536 36 - - HYPH cord-005453-4057qib7 6536 37 inhibitors inhibitor NNS cord-005453-4057qib7 6536 38 ( ( -LRB- cord-005453-4057qib7 6536 39 CIs CIs NNP cord-005453-4057qib7 6536 40 ) ) -RRB- cord-005453-4057qib7 6536 41 has have VBZ cord-005453-4057qib7 6536 42 been be VBN cord-005453-4057qib7 6536 43 increasingly increasingly RB cord-005453-4057qib7 6536 44 used use VBN cord-005453-4057qib7 6536 45 as as IN cord-005453-4057qib7 6536 46 GVHD GVHD NNP cord-005453-4057qib7 6536 47 prophylaxis prophylaxis NN cord-005453-4057qib7 6536 48 after after IN cord-005453-4057qib7 6536 49 HLA HLA NNP cord-005453-4057qib7 6536 50 - - HYPH cord-005453-4057qib7 6536 51 haploidentical haploidentical JJ cord-005453-4057qib7 6536 52 or or CC cord-005453-4057qib7 6536 53 matched match VBN cord-005453-4057qib7 6536 54 hematopoietic hematopoietic JJ cord-005453-4057qib7 6536 55 stem stem NN cord-005453-4057qib7 6536 56 cell cell NN cord-005453-4057qib7 6536 57 transplantation transplantation NN cord-005453-4057qib7 6536 58 ( ( -LRB- cord-005453-4057qib7 6536 59 HSCT HSCT NNP cord-005453-4057qib7 6536 60 ) ) -RRB- cord-005453-4057qib7 6536 61 . . . cord-005453-4057qib7 6537 1 However however RB cord-005453-4057qib7 6537 2 , , , cord-005453-4057qib7 6537 3 CIs CIs NNP cord-005453-4057qib7 6537 4 could could MD cord-005453-4057qib7 6537 5 hamper hamper VB cord-005453-4057qib7 6537 6 reconstitution reconstitution NN cord-005453-4057qib7 6537 7 of of IN cord-005453-4057qib7 6537 8 regulatory regulatory JJ cord-005453-4057qib7 6537 9 T t NN cord-005453-4057qib7 6537 10 cells cell NNS cord-005453-4057qib7 6537 11 ( ( -LRB- cord-005453-4057qib7 6537 12 Tregs Tregs NNP cord-005453-4057qib7 6537 13 ) ) -RRB- cord-005453-4057qib7 6537 14 and and CC cord-005453-4057qib7 6537 15 tolerance tolerance NN cord-005453-4057qib7 6537 16 induction induction NN cord-005453-4057qib7 6537 17 after after IN cord-005453-4057qib7 6537 18 HSCT HSCT NNP cord-005453-4057qib7 6537 19 , , , cord-005453-4057qib7 6537 20 facilitating facilitate VBG cord-005453-4057qib7 6537 21 us -PRON- PRP cord-005453-4057qib7 6537 22 to to TO cord-005453-4057qib7 6537 23 develop develop VB cord-005453-4057qib7 6537 24 novel novel JJ cord-005453-4057qib7 6537 25 CI ci NN cord-005453-4057qib7 6537 26 - - HYPH cord-005453-4057qib7 6537 27 free free JJ cord-005453-4057qib7 6537 28 / / SYM cord-005453-4057qib7 6537 29 PTCY ptcy NN cord-005453-4057qib7 6537 30 - - HYPH cord-005453-4057qib7 6537 31 based base VBN cord-005453-4057qib7 6537 32 GVHD GVHD NNP cord-005453-4057qib7 6537 33 prophylaxis prophylaxis NN cord-005453-4057qib7 6537 34 . . . cord-005453-4057qib7 6538 1 In in IN cord-005453-4057qib7 6538 2 the the DT cord-005453-4057qib7 6538 3 current current JJ cord-005453-4057qib7 6538 4 study study NN cord-005453-4057qib7 6538 5 , , , cord-005453-4057qib7 6538 6 we -PRON- PRP cord-005453-4057qib7 6538 7 developed develop VBD cord-005453-4057qib7 6538 8 a a DT cord-005453-4057qib7 6538 9 novel novel JJ cord-005453-4057qib7 6538 10 GVHD GVHD NNP cord-005453-4057qib7 6538 11 prophylaxis prophylaxis NN cord-005453-4057qib7 6538 12 in in IN cord-005453-4057qib7 6538 13 which which WDT cord-005453-4057qib7 6538 14 PTCY PTCY NNP cord-005453-4057qib7 6538 15 was be VBD cord-005453-4057qib7 6538 16 combined combine VBN cord-005453-4057qib7 6538 17 with with IN cord-005453-4057qib7 6538 18 short short JJ cord-005453-4057qib7 6538 19 - - HYPH cord-005453-4057qib7 6538 20 term term NN cord-005453-4057qib7 6538 21 administration administration NN cord-005453-4057qib7 6538 22 of of IN cord-005453-4057qib7 6538 23 KRP203 KRP203 NNP cord-005453-4057qib7 6538 24 , , , cord-005453-4057qib7 6538 25 a a DT cord-005453-4057qib7 6538 26 selective selective JJ cord-005453-4057qib7 6538 27 agonist agonist NN cord-005453-4057qib7 6538 28 of of IN cord-005453-4057qib7 6538 29 sphingosine-1-phosphate sphingosine-1-phosphate NNP cord-005453-4057qib7 6538 30 receptor receptor NN cord-005453-4057qib7 6538 31 type type NN cord-005453-4057qib7 6538 32 1 1 CD cord-005453-4057qib7 6538 33 ( ( -LRB- cord-005453-4057qib7 6538 34 S1PR1 S1PR1 NNP cord-005453-4057qib7 6538 35 ) ) -RRB- cord-005453-4057qib7 6538 36 , , , cord-005453-4057qib7 6538 37 using use VBG cord-005453-4057qib7 6538 38 murine murine JJ cord-005453-4057qib7 6538 39 models model NNS cord-005453-4057qib7 6538 40 of of IN cord-005453-4057qib7 6538 41 MHC MHC NNP cord-005453-4057qib7 6538 42 haploidentical haploidentical JJ cord-005453-4057qib7 6538 43 bone bone NN cord-005453-4057qib7 6538 44 marrow marrow NN cord-005453-4057qib7 6538 45 transplantation transplantation NN cord-005453-4057qib7 6538 46 ( ( -LRB- cord-005453-4057qib7 6538 47 BMT BMT NNP cord-005453-4057qib7 6538 48 ) ) -RRB- cord-005453-4057qib7 6538 49 . . . cord-005453-4057qib7 6539 1 Methods method NNS cord-005453-4057qib7 6539 2 : : : cord-005453-4057qib7 6539 3 B6D2F1 b6d2f1 NN cord-005453-4057qib7 6539 4 ( ( -LRB- cord-005453-4057qib7 6539 5 H-2 H-2 NNP cord-005453-4057qib7 6539 6 b b NN cord-005453-4057qib7 6539 7 / / SYM cord-005453-4057qib7 6539 8 d d NN cord-005453-4057qib7 6539 9 ) ) -RRB- cord-005453-4057qib7 6540 1 recipients recipient NNS cord-005453-4057qib7 6540 2 were be VBD cord-005453-4057qib7 6540 3 lethally lethally RB cord-005453-4057qib7 6540 4 irradiated irradiate VBN cord-005453-4057qib7 6540 5 and and CC cord-005453-4057qib7 6540 6 transplanted transplant VBN cord-005453-4057qib7 6540 7 with with IN cord-005453-4057qib7 6540 8 bone bone NN cord-005453-4057qib7 6540 9 marrow marrow NN cord-005453-4057qib7 6540 10 cells cell NNS cord-005453-4057qib7 6540 11 and and CC cord-005453-4057qib7 6540 12 splenocytes splenocyte NNS cord-005453-4057qib7 6540 13 from from IN cord-005453-4057qib7 6540 14 allogeneic allogeneic NN cord-005453-4057qib7 6540 15 B6 b6 NN cord-005453-4057qib7 6540 16 ( ( -LRB- cord-005453-4057qib7 6540 17 H-2 H-2 NNP cord-005453-4057qib7 6540 18 b b NN cord-005453-4057qib7 6540 19 ) ) -RRB- cord-005453-4057qib7 6540 20 donors donor NNS cord-005453-4057qib7 6540 21 . . . cord-005453-4057qib7 6541 1 CY CY NNP cord-005453-4057qib7 6541 2 at at IN cord-005453-4057qib7 6541 3 a a DT cord-005453-4057qib7 6541 4 dose dose NN cord-005453-4057qib7 6541 5 of of IN cord-005453-4057qib7 6541 6 50 50 CD cord-005453-4057qib7 6541 7 mg mg NNP cord-005453-4057qib7 6541 8 / / SYM cord-005453-4057qib7 6541 9 kg kg NNP cord-005453-4057qib7 6541 10 was be VBD cord-005453-4057qib7 6541 11 intraperitoneally intraperitoneally RB cord-005453-4057qib7 6541 12 injected inject VBN cord-005453-4057qib7 6541 13 into into IN cord-005453-4057qib7 6541 14 the the DT cord-005453-4057qib7 6541 15 recipients recipient NNS cord-005453-4057qib7 6541 16 on on IN cord-005453-4057qib7 6541 17 day day NN cord-005453-4057qib7 6541 18 +3 +3 NN cord-005453-4057qib7 6541 19 , , , cord-005453-4057qib7 6541 20 and and CC cord-005453-4057qib7 6541 21 KRP KRP NNP cord-005453-4057qib7 6541 22 at at IN cord-005453-4057qib7 6541 23 a a DT cord-005453-4057qib7 6541 24 dose dose NN cord-005453-4057qib7 6541 25 of of IN cord-005453-4057qib7 6541 26 1.0 1.0 CD cord-005453-4057qib7 6541 27 mg mg NNP cord-005453-4057qib7 6541 28 / / SYM cord-005453-4057qib7 6541 29 kg kg NNP cord-005453-4057qib7 6541 30 was be VBD cord-005453-4057qib7 6541 31 orally orally RB cord-005453-4057qib7 6541 32 administrated administrate VBN cord-005453-4057qib7 6541 33 daily daily RB cord-005453-4057qib7 6541 34 from from IN cord-005453-4057qib7 6541 35 day day NN cord-005453-4057qib7 6541 36 0 0 CD cord-005453-4057qib7 6541 37 to to IN cord-005453-4057qib7 6541 38 day day NN cord-005453-4057qib7 6541 39 +4 +4 NN cord-005453-4057qib7 6541 40 after after IN cord-005453-4057qib7 6541 41 BMT BMT NNP cord-005453-4057qib7 6541 42 . . . cord-005453-4057qib7 6542 1 Donor donor NN cord-005453-4057qib7 6542 2 T t NN cord-005453-4057qib7 6542 3 cells cell NNS cord-005453-4057qib7 6542 4 in in IN cord-005453-4057qib7 6542 5 the the DT cord-005453-4057qib7 6542 6 target target NN cord-005453-4057qib7 6542 7 organs organ NNS cord-005453-4057qib7 6542 8 and and CC cord-005453-4057qib7 6542 9 secondary secondary JJ cord-005453-4057qib7 6542 10 lymphoid lymphoid JJ cord-005453-4057qib7 6542 11 organs organ NNS cord-005453-4057qib7 6542 12 were be VBD cord-005453-4057qib7 6542 13 evaluated evaluate VBN cord-005453-4057qib7 6542 14 by by IN cord-005453-4057qib7 6542 15 flow flow NN cord-005453-4057qib7 6542 16 cytometric cytometric NNP cord-005453-4057qib7 6542 17 analysis analysis NN cord-005453-4057qib7 6542 18 . . . cord-005453-4057qib7 6543 1 Plasma plasma NN cord-005453-4057qib7 6543 2 levels level NNS cord-005453-4057qib7 6543 3 of of IN cord-005453-4057qib7 6543 4 TNF TNF NNP cord-005453-4057qib7 6543 5 - - HYPH cord-005453-4057qib7 6543 6 α α NNP cord-005453-4057qib7 6543 7 were be VBD cord-005453-4057qib7 6543 8 determined determine VBN cord-005453-4057qib7 6543 9 using use VBG cord-005453-4057qib7 6543 10 cytometric cytometric NN cord-005453-4057qib7 6543 11 beads bead NNS cord-005453-4057qib7 6543 12 array array NN cord-005453-4057qib7 6543 13 . . . cord-005453-4057qib7 6544 1 To to TO cord-005453-4057qib7 6544 2 evaluate evaluate VB cord-005453-4057qib7 6544 3 graft graft NN cord-005453-4057qib7 6544 4 - - HYPH cord-005453-4057qib7 6544 5 versus versus IN cord-005453-4057qib7 6544 6 - - HYPH cord-005453-4057qib7 6544 7 leukemia leukemia NN cord-005453-4057qib7 6544 8 ( ( -LRB- cord-005453-4057qib7 6544 9 GVL gvl NN cord-005453-4057qib7 6544 10 ) ) -RRB- cord-005453-4057qib7 6544 11 effects effect NNS cord-005453-4057qib7 6544 12 , , , cord-005453-4057qib7 6544 13 recipient recipient NN cord-005453-4057qib7 6544 14 mice mouse NNS cord-005453-4057qib7 6544 15 were be VBD cord-005453-4057qib7 6544 16 intravenously intravenously RB cord-005453-4057qib7 6544 17 injected inject VBN cord-005453-4057qib7 6544 18 with with IN cord-005453-4057qib7 6544 19 luciferase luciferase NN cord-005453-4057qib7 6544 20 - - HYPH cord-005453-4057qib7 6544 21 transduced transduce VBN cord-005453-4057qib7 6544 22 P815 P815 NNP cord-005453-4057qib7 6544 23 cells cell NNS cord-005453-4057qib7 6544 24 ( ( -LRB- cord-005453-4057qib7 6544 25 P815-luc P815-luc NNP cord-005453-4057qib7 6544 26 ) ) -RRB- cord-005453-4057qib7 6544 27 on on IN cord-005453-4057qib7 6544 28 day day NN cord-005453-4057qib7 6544 29 0 0 CD cord-005453-4057qib7 6544 30 , , , cord-005453-4057qib7 6544 31 and and CC cord-005453-4057qib7 6544 32 in in IN cord-005453-4057qib7 6544 33 vivo vivo NNP cord-005453-4057qib7 6544 34 bioluminescence bioluminescence NN cord-005453-4057qib7 6544 35 imagingwas imagingwas NNP cord-005453-4057qib7 6544 36 conducted conduct VBN cord-005453-4057qib7 6544 37 weekly weekly RB cord-005453-4057qib7 6544 38 after after IN cord-005453-4057qib7 6544 39 BMT BMT NNP cord-005453-4057qib7 6544 40 . . . cord-005453-4057qib7 6545 1 Results result NNS cord-005453-4057qib7 6545 2 : : : cord-005453-4057qib7 6546 1 Severe severe JJ cord-005453-4057qib7 6546 2 GVHD GVHD NNP cord-005453-4057qib7 6546 3 was be VBD cord-005453-4057qib7 6546 4 developed develop VBN cord-005453-4057qib7 6546 5 in in IN cord-005453-4057qib7 6546 6 allogeneic allogeneic NN cord-005453-4057qib7 6546 7 recipients recipient NNS cord-005453-4057qib7 6546 8 and and CC cord-005453-4057qib7 6546 9 all all DT cord-005453-4057qib7 6546 10 mice mouse NNS cord-005453-4057qib7 6546 11 died die VBD cord-005453-4057qib7 6546 12 by by IN cord-005453-4057qib7 6546 13 day day NN cord-005453-4057qib7 6546 14 50 50 CD cord-005453-4057qib7 6546 15 after after IN cord-005453-4057qib7 6546 16 BMT.PTCY bmt.ptcy NN cord-005453-4057qib7 6546 17 alone alone RB cord-005453-4057qib7 6546 18 at at IN cord-005453-4057qib7 6546 19 a a DT cord-005453-4057qib7 6546 20 dose dose NN cord-005453-4057qib7 6546 21 of of IN cord-005453-4057qib7 6546 22 50 50 CD cord-005453-4057qib7 6546 23 mg mg NNP cord-005453-4057qib7 6546 24 / / SYM cord-005453-4057qib7 6546 25 kg kg NNP cord-005453-4057qib7 6546 26 significantly significantly RB cord-005453-4057qib7 6546 27 ameliorated ameliorate VBD cord-005453-4057qib7 6546 28 GVHD GVHD NNP cord-005453-4057qib7 6546 29 and and CC cord-005453-4057qib7 6546 30 30 30 CD cord-005453-4057qib7 6546 31 % % NN cord-005453-4057qib7 6546 32 of of IN cord-005453-4057qib7 6546 33 PTCY PTCY NNP cord-005453-4057qib7 6546 34 - - HYPH cord-005453-4057qib7 6546 35 treated treat VBN cord-005453-4057qib7 6546 36 allogeneic allogeneic IN cord-005453-4057qib7 6546 37 recipients recipient NNS cord-005453-4057qib7 6546 38 survived survive VBD cord-005453-4057qib7 6546 39 . . . cord-005453-4057qib7 6547 1 Oral oral JJ cord-005453-4057qib7 6547 2 administration administration NN cord-005453-4057qib7 6547 3 of of IN cord-005453-4057qib7 6547 4 KRP203 KRP203 NNP cord-005453-4057qib7 6547 5 alone alone RB cord-005453-4057qib7 6547 6 enhanced enhance VBN cord-005453-4057qib7 6547 7 contraction contraction NN cord-005453-4057qib7 6547 8 of of IN cord-005453-4057qib7 6547 9 donor donor NN cord-005453-4057qib7 6547 10 T t NN cord-005453-4057qib7 6547 11 cells cell NNS cord-005453-4057qib7 6547 12 in in IN cord-005453-4057qib7 6547 13 the the DT cord-005453-4057qib7 6547 14 lymph lymph NN cord-005453-4057qib7 6547 15 nodes node NNS cord-005453-4057qib7 6547 16 and and CC cord-005453-4057qib7 6547 17 also also RB cord-005453-4057qib7 6547 18 ameliorated ameliorate VBD cord-005453-4057qib7 6547 19 GVHD GVHD NNP cord-005453-4057qib7 6547 20 as as IN cord-005453-4057qib7 6547 21 has have VBZ cord-005453-4057qib7 6547 22 been be VBN cord-005453-4057qib7 6547 23 previously previously RB cord-005453-4057qib7 6547 24 shown show VBN cord-005453-4057qib7 6547 25 with with IN cord-005453-4057qib7 6547 26 multi multi JJ cord-005453-4057qib7 6547 27 - - JJ cord-005453-4057qib7 6547 28 S1PR s1pr JJ cord-005453-4057qib7 6547 29 agonist agonist NN cord-005453-4057qib7 6547 30 , , , cord-005453-4057qib7 6547 31 fingolimod fingolimod NNP cord-005453-4057qib7 6547 32 . . . cord-005453-4057qib7 6548 1 Next next RB cord-005453-4057qib7 6548 2 , , , cord-005453-4057qib7 6548 3 we -PRON- PRP cord-005453-4057qib7 6548 4 tested test VBD cord-005453-4057qib7 6548 5 if if IN cord-005453-4057qib7 6548 6 shortterm shortterm JJ cord-005453-4057qib7 6548 7 KRP203 krp203 NN cord-005453-4057qib7 6548 8 on on IN cord-005453-4057qib7 6548 9 days day NNS cord-005453-4057qib7 6548 10 0 0 CD cord-005453-4057qib7 6548 11 to to IN cord-005453-4057qib7 6548 12 +4 +4 ADD cord-005453-4057qib7 6548 13 added add VBN cord-005453-4057qib7 6548 14 to to IN cord-005453-4057qib7 6548 15 PTCY PTCY NNP cord-005453-4057qib7 6548 16 enhances enhance VBZ cord-005453-4057qib7 6548 17 anti anti JJ cord-005453-4057qib7 6548 18 - - JJ cord-005453-4057qib7 6548 19 GVHD gvhd JJ cord-005453-4057qib7 6548 20 effects effect NNS cord-005453-4057qib7 6548 21 of of IN cord-005453-4057qib7 6548 22 PTCY PTCY NNP cord-005453-4057qib7 6548 23 . . . cord-005453-4057qib7 6549 1 We -PRON- PRP cord-005453-4057qib7 6549 2 found find VBD cord-005453-4057qib7 6549 3 that that IN cord-005453-4057qib7 6549 4 survivals survival NNS cord-005453-4057qib7 6549 5 of of IN cord-005453-4057qib7 6549 6 PTCY+KRP203 ptcy+krp203 JJ cord-005453-4057qib7 6549 7 group group NN cord-005453-4057qib7 6549 8 were be VBD cord-005453-4057qib7 6549 9 significantly significantly RB cord-005453-4057qib7 6549 10 prolonged prolong VBN cord-005453-4057qib7 6549 11 compared compare VBN cord-005453-4057qib7 6549 12 to to IN cord-005453-4057qib7 6549 13 those those DT cord-005453-4057qib7 6549 14 of of IN cord-005453-4057qib7 6549 15 PTCY PTCY NNP cord-005453-4057qib7 6549 16 - - HYPH cord-005453-4057qib7 6549 17 alone alone RB cord-005453-4057qib7 6549 18 group group NN cord-005453-4057qib7 6549 19 ( ( -LRB- cord-005453-4057qib7 6549 20 Figure figure NN cord-005453-4057qib7 6549 21 A A NNP cord-005453-4057qib7 6549 22 ) ) -RRB- cord-005453-4057qib7 6549 23 . . . cord-005453-4057qib7 6550 1 Plasma plasma NN cord-005453-4057qib7 6550 2 levels level NNS cord-005453-4057qib7 6550 3 of of IN cord-005453-4057qib7 6550 4 TNF TNF NNP cord-005453-4057qib7 6550 5 - - HYPH cord-005453-4057qib7 6550 6 a a NNP cord-005453-4057qib7 6550 7 , , , cord-005453-4057qib7 6550 8 clinical clinical JJ cord-005453-4057qib7 6550 9 GVHD gvhd NN cord-005453-4057qib7 6550 10 scores score NNS cord-005453-4057qib7 6550 11 ( ( -LRB- cord-005453-4057qib7 6550 12 Figure figure NN cord-005453-4057qib7 6550 13 B B NNP cord-005453-4057qib7 6550 14 ) ) -RRB- cord-005453-4057qib7 6550 15 , , , cord-005453-4057qib7 6550 16 and and CC cord-005453-4057qib7 6550 17 donor donor NN cord-005453-4057qib7 6550 18 T t NN cord-005453-4057qib7 6550 19 - - HYPH cord-005453-4057qib7 6550 20 cell cell NN cord-005453-4057qib7 6550 21 infiltration infiltration NN cord-005453-4057qib7 6550 22 into into IN cord-005453-4057qib7 6550 23 the the DT cord-005453-4057qib7 6550 24 target target NN cord-005453-4057qib7 6550 25 organs organ NNS cord-005453-4057qib7 6550 26 such such JJ cord-005453-4057qib7 6550 27 as as IN cord-005453-4057qib7 6550 28 the the DT cord-005453-4057qib7 6550 29 gut gut NN cord-005453-4057qib7 6550 30 and and CC cord-005453-4057qib7 6550 31 skin skin NN cord-005453-4057qib7 6550 32 were be VBD cord-005453-4057qib7 6550 33 also also RB cord-005453-4057qib7 6550 34 significantly significantly RB cord-005453-4057qib7 6550 35 reduced reduce VBN cord-005453-4057qib7 6550 36 in in IN cord-005453-4057qib7 6550 37 PTCY PTCY NNP cord-005453-4057qib7 6550 38 + + CC cord-005453-4057qib7 6550 39 KRP203 krp203 NN cord-005453-4057qib7 6550 40 group group NN cord-005453-4057qib7 6550 41 compared compare VBN cord-005453-4057qib7 6550 42 to to IN cord-005453-4057qib7 6550 43 PTCY PTCY NNP cord-005453-4057qib7 6550 44 - - HYPH cord-005453-4057qib7 6550 45 alone alone RB cord-005453-4057qib7 6550 46 group group NN cord-005453-4057qib7 6550 47 ( ( -LRB- cord-005453-4057qib7 6550 48 Figure figure NN cord-005453-4057qib7 6550 49 C c NN cord-005453-4057qib7 6550 50 and and CC cord-005453-4057qib7 6550 51 D D NNP cord-005453-4057qib7 6550 52 ) ) -RRB- cord-005453-4057qib7 6550 53 . . . cord-005453-4057qib7 6551 1 Unlike unlike IN cord-005453-4057qib7 6551 2 CIs CIs NNP cord-005453-4057qib7 6551 3 , , , cord-005453-4057qib7 6551 4 addition addition NN cord-005453-4057qib7 6551 5 of of IN cord-005453-4057qib7 6551 6 KRP203 krp203 NN cord-005453-4057qib7 6551 7 to to IN cord-005453-4057qib7 6551 8 PTCY PTCY NNP cord-005453-4057qib7 6551 9 promoted promote VBD cord-005453-4057qib7 6551 10 Treg Treg NNP cord-005453-4057qib7 6551 11 reconstitution reconstitution NN cord-005453-4057qib7 6551 12 after after IN cord-005453-4057qib7 6551 13 BMT BMT NNP cord-005453-4057qib7 6551 14 . . . cord-005453-4057qib7 6552 1 Finally finally RB cord-005453-4057qib7 6552 2 , , , cord-005453-4057qib7 6552 3 bioluminescence bioluminescence NN cord-005453-4057qib7 6552 4 imaging imaging NN cord-005453-4057qib7 6552 5 demonstrated demonstrate VBD cord-005453-4057qib7 6552 6 that that IN cord-005453-4057qib7 6552 7 proliferation proliferation NN cord-005453-4057qib7 6552 8 of of IN cord-005453-4057qib7 6552 9 P815-luc P815-luc NNP cord-005453-4057qib7 6552 10 injected inject VBD cord-005453-4057qib7 6552 11 on on IN cord-005453-4057qib7 6552 12 day day NN cord-005453-4057qib7 6552 13 0 0 NFP cord-005453-4057qib7 6552 14 was be VBD cord-005453-4057qib7 6552 15 significantly significantly RB cord-005453-4057qib7 6552 16 delayed delay VBN cord-005453-4057qib7 6552 17 in in IN cord-005453-4057qib7 6552 18 PTCY PTCY NNP cord-005453-4057qib7 6552 19 + + CC cord-005453-4057qib7 6553 1 KRP203-treated krp203-treated JJ cord-005453-4057qib7 6553 2 allogeneic allogeneic IN cord-005453-4057qib7 6553 3 recipients recipient NNS cord-005453-4057qib7 6553 4 compared compare VBN cord-005453-4057qib7 6553 5 to to TO cord-005453-4057qib7 6553 6 control control NN cord-005453-4057qib7 6553 7 mice mouse NNS cord-005453-4057qib7 6553 8 transplanted transplant VBN cord-005453-4057qib7 6553 9 only only RB cord-005453-4057qib7 6553 10 with with IN cord-005453-4057qib7 6553 11 T t NN cord-005453-4057qib7 6553 12 - - HYPH cord-005453-4057qib7 6553 13 cell cell NN cord-005453-4057qib7 6553 14 depleted deplete VBN cord-005453-4057qib7 6553 15 bone bone NN cord-005453-4057qib7 6553 16 marrow marrow NN cord-005453-4057qib7 6553 17 cells cell NNS cord-005453-4057qib7 6553 18 , , , cord-005453-4057qib7 6553 19 suggesting suggest VBG cord-005453-4057qib7 6553 20 that that IN cord-005453-4057qib7 6553 21 significant significant JJ cord-005453-4057qib7 6553 22 GVL GVL NNP cord-005453-4057qib7 6553 23 effects effect NNS cord-005453-4057qib7 6553 24 persisted persist VBD cord-005453-4057qib7 6553 25 in in IN cord-005453-4057qib7 6553 26 PTCY+KRP203-treated PTCY+KRP203-treated NNP cord-005453-4057qib7 6553 27 recipients recipient NNS cord-005453-4057qib7 6553 28 . . . cord-005453-4057qib7 6554 1 Conclusions conclusion NNS cord-005453-4057qib7 6554 2 : : : cord-005453-4057qib7 6555 1 A a DT cord-005453-4057qib7 6555 2 combination combination NN cord-005453-4057qib7 6555 3 of of IN cord-005453-4057qib7 6555 4 short short JJ cord-005453-4057qib7 6555 5 - - HYPH cord-005453-4057qib7 6555 6 term term NN cord-005453-4057qib7 6555 7 KRP203 KRP203 NNP cord-005453-4057qib7 6555 8 and and CC cord-005453-4057qib7 6555 9 PTCY PTCY NNP cord-005453-4057qib7 6555 10 is be VBZ cord-005453-4057qib7 6555 11 a a DT cord-005453-4057qib7 6555 12 promising promising JJ cord-005453-4057qib7 6555 13 novel novel JJ cord-005453-4057qib7 6555 14 calcineurin calcineurin NN cord-005453-4057qib7 6555 15 - - HYPH cord-005453-4057qib7 6555 16 free free JJ cord-005453-4057qib7 6555 17 GVHD GVHD NNP cord-005453-4057qib7 6555 18 prophylaxis prophylaxis NN cord-005453-4057qib7 6555 19 in in IN cord-005453-4057qib7 6555 20 MHC MHC NNP cord-005453-4057qib7 6555 21 - - HYPH cord-005453-4057qib7 6555 22 haploidentical haploidentical JJ cord-005453-4057qib7 6555 23 SCT SCT NNP cord-005453-4057qib7 6555 24 . . . cord-005453-4057qib7 6556 1 We -PRON- PRP cord-005453-4057qib7 6556 2 recently recently RB cord-005453-4057qib7 6556 3 showed show VBD cord-005453-4057qib7 6556 4 that that IN cord-005453-4057qib7 6556 5 donor donor NN cord-005453-4057qib7 6556 6 iNKT inkt NN cord-005453-4057qib7 6556 7 cells cell NNS cord-005453-4057qib7 6556 8 can can MD cord-005453-4057qib7 6556 9 be be VB cord-005453-4057qib7 6556 10 expanded expand VBN cord-005453-4057qib7 6556 11 ex ex FW cord-005453-4057qib7 6556 12 vivo vivo NN cord-005453-4057qib7 6556 13 and and CC cord-005453-4057qib7 6556 14 that that IN cord-005453-4057qib7 6556 15 they -PRON- PRP cord-005453-4057qib7 6556 16 are be VBP cord-005453-4057qib7 6556 17 able able JJ cord-005453-4057qib7 6556 18 to to TO cord-005453-4057qib7 6556 19 prevent prevent VB cord-005453-4057qib7 6556 20 activation activation NN cord-005453-4057qib7 6556 21 and and CC cord-005453-4057qib7 6556 22 proliferation proliferation NN cord-005453-4057qib7 6556 23 of of IN cord-005453-4057qib7 6556 24 alloreactive alloreactive JJ cord-005453-4057qib7 6556 25 donor donor NN cord-005453-4057qib7 6556 26 T t NN cord-005453-4057qib7 6556 27 cells cell NNS cord-005453-4057qib7 6556 28 while while IN cord-005453-4057qib7 6556 29 promoting promote VBG cord-005453-4057qib7 6556 30 efficient efficient JJ cord-005453-4057qib7 6556 31 graft graft NN cord-005453-4057qib7 6556 32 - - HYPH cord-005453-4057qib7 6556 33 versus versus IN cord-005453-4057qib7 6556 34 - - HYPH cord-005453-4057qib7 6556 35 leukemia leukemia NN cord-005453-4057qib7 6556 36 effects effect NNS cord-005453-4057qib7 6556 37 ( ( -LRB- cord-005453-4057qib7 6556 38 Schmid Schmid NNP cord-005453-4057qib7 6556 39 et et NNP cord-005453-4057qib7 6556 40 al al NNP cord-005453-4057qib7 6556 41 . . . cord-005453-4057qib7 6556 42 2018 2018 CD cord-005453-4057qib7 6556 43 ) ) -RRB- cord-005453-4057qib7 6556 44 . . . cord-005453-4057qib7 6557 1 However however RB cord-005453-4057qib7 6557 2 , , , cord-005453-4057qib7 6557 3 the the DT cord-005453-4057qib7 6557 4 underlying underlie VBG cord-005453-4057qib7 6557 5 mechanisms mechanism NNS cord-005453-4057qib7 6557 6 how how WRB cord-005453-4057qib7 6557 7 human human JJ cord-005453-4057qib7 6557 8 iNKT inkt JJ cord-005453-4057qib7 6557 9 cells cell NNS cord-005453-4057qib7 6557 10 induce induce VBP cord-005453-4057qib7 6557 11 immune immune JJ cord-005453-4057qib7 6557 12 tolerance tolerance NN cord-005453-4057qib7 6557 13 after after IN cord-005453-4057qib7 6557 14 allogeneic allogeneic NN cord-005453-4057qib7 6557 15 HCT hct NN cord-005453-4057qib7 6557 16 are be VBP cord-005453-4057qib7 6557 17 not not RB cord-005453-4057qib7 6557 18 fully fully RB cord-005453-4057qib7 6557 19 understood understand VBN cord-005453-4057qib7 6557 20 . . . cord-005453-4057qib7 6558 1 Methods method NNS cord-005453-4057qib7 6558 2 : : : cord-005453-4057qib7 6558 3 Monocyte Monocyte NNP cord-005453-4057qib7 6558 4 - - HYPH cord-005453-4057qib7 6558 5 derived derive VBN cord-005453-4057qib7 6558 6 dendritic dendritic JJ cord-005453-4057qib7 6558 7 cells cell NNS cord-005453-4057qib7 6558 8 ( ( -LRB- cord-005453-4057qib7 6558 9 DCs DCs NNP cord-005453-4057qib7 6558 10 ) ) -RRB- cord-005453-4057qib7 6558 11 were be VBD cord-005453-4057qib7 6558 12 cultured culture VBN cord-005453-4057qib7 6558 13 in in IN cord-005453-4057qib7 6558 14 a a DT cord-005453-4057qib7 6558 15 mixed mixed JJ cord-005453-4057qib7 6558 16 lymphocyte lymphocyte NN cord-005453-4057qib7 6558 17 reaction reaction NN cord-005453-4057qib7 6558 18 with with IN cord-005453-4057qib7 6558 19 MHCmismatched MHCmismatched NNP cord-005453-4057qib7 6558 20 T T NNP cord-005453-4057qib7 6558 21 cells cell NNS cord-005453-4057qib7 6558 22 and and CC cord-005453-4057qib7 6558 23 culture culture NN cord-005453-4057qib7 6558 24 - - HYPH cord-005453-4057qib7 6558 25 expanded expand VBN cord-005453-4057qib7 6558 26 iNKT inkt JJ cord-005453-4057qib7 6558 27 cells cell NNS cord-005453-4057qib7 6558 28 . . . cord-005453-4057qib7 6559 1 Tcell Tcell NNP cord-005453-4057qib7 6559 2 activation activation NN cord-005453-4057qib7 6559 3 and and CC cord-005453-4057qib7 6559 4 proliferation proliferation NN cord-005453-4057qib7 6559 5 was be VBD cord-005453-4057qib7 6559 6 analyzed analyze VBN cord-005453-4057qib7 6559 7 by by IN cord-005453-4057qib7 6559 8 multiparametric multiparametric JJ cord-005453-4057qib7 6559 9 flow flow NN cord-005453-4057qib7 6559 10 cytometry cytometry NN cord-005453-4057qib7 6559 11 and and CC cord-005453-4057qib7 6559 12 released release VBN cord-005453-4057qib7 6559 13 cytokines cytokine NNS cord-005453-4057qib7 6559 14 were be VBD cord-005453-4057qib7 6559 15 measured measure VBN cord-005453-4057qib7 6559 16 via via IN cord-005453-4057qib7 6559 17 multiplex multiplex NN cord-005453-4057qib7 6559 18 analysis analysis NN cord-005453-4057qib7 6559 19 . . . cord-005453-4057qib7 6560 1 Transwell Transwell NNP cord-005453-4057qib7 6560 2 assays assay NNS cord-005453-4057qib7 6560 3 and and CC cord-005453-4057qib7 6560 4 imaging image VBG cord-005453-4057qib7 6560 5 flow flow NN cord-005453-4057qib7 6560 6 cytometry cytometry NN cord-005453-4057qib7 6560 7 were be VBD cord-005453-4057qib7 6560 8 performed perform VBN cord-005453-4057qib7 6560 9 to to TO cord-005453-4057qib7 6560 10 elucidate elucidate VB cord-005453-4057qib7 6560 11 cellcell cellcell NN cord-005453-4057qib7 6560 12 interactions interaction NNS cord-005453-4057qib7 6560 13 . . . cord-005453-4057qib7 6561 1 Bead bead NN cord-005453-4057qib7 6561 2 - - HYPH cord-005453-4057qib7 6561 3 controlled control VBN cord-005453-4057qib7 6561 4 flow flow NN cord-005453-4057qib7 6561 5 cytometry cytometry NN cord-005453-4057qib7 6561 6 - - HYPH cord-005453-4057qib7 6561 7 based base VBN cord-005453-4057qib7 6561 8 cytotoxicity cytotoxicity NN cord-005453-4057qib7 6561 9 assays assay NNS cord-005453-4057qib7 6561 10 were be VBD cord-005453-4057qib7 6561 11 used use VBN cord-005453-4057qib7 6561 12 to to TO cord-005453-4057qib7 6561 13 evaluate evaluate VB cord-005453-4057qib7 6561 14 DC DC NNP cord-005453-4057qib7 6561 15 apoptosis apoptosis NN cord-005453-4057qib7 6561 16 . . . cord-005453-4057qib7 6562 1 Apoptotic apoptotic JJ cord-005453-4057qib7 6562 2 DCs dc NNS cord-005453-4057qib7 6562 3 were be VBD cord-005453-4057qib7 6562 4 then then RB cord-005453-4057qib7 6562 5 purified purify VBN cord-005453-4057qib7 6562 6 by by IN cord-005453-4057qib7 6562 7 fluorescence fluorescence NN cord-005453-4057qib7 6562 8 - - HYPH cord-005453-4057qib7 6562 9 activated activate VBN cord-005453-4057qib7 6562 10 cell cell NN cord-005453-4057qib7 6562 11 sorting sorting NN cord-005453-4057qib7 6562 12 to to TO cord-005453-4057qib7 6562 13 investigate investigate VB cord-005453-4057qib7 6562 14 their -PRON- PRP$ cord-005453-4057qib7 6562 15 tolerogenic tolerogenic NN cord-005453-4057qib7 6562 16 potential potential NN cord-005453-4057qib7 6562 17 to to IN cord-005453-4057qib7 6562 18 prime prime JJ cord-005453-4057qib7 6562 19 regulatory regulatory JJ cord-005453-4057qib7 6562 20 T t NN cord-005453-4057qib7 6562 21 cells cell NNS cord-005453-4057qib7 6562 22 ( ( -LRB- cord-005453-4057qib7 6562 23 Tregs Tregs NNP cord-005453-4057qib7 6562 24 ) ) -RRB- cord-005453-4057qib7 6562 25 . . . cord-005453-4057qib7 6563 1 Results result NNS cord-005453-4057qib7 6563 2 : : : cord-005453-4057qib7 6564 1 The the DT cord-005453-4057qib7 6564 2 addition addition NN cord-005453-4057qib7 6564 3 of of IN cord-005453-4057qib7 6564 4 iNKT inkt JJ cord-005453-4057qib7 6564 5 cells cell NNS cord-005453-4057qib7 6564 6 to to IN cord-005453-4057qib7 6564 7 mixed mixed JJ cord-005453-4057qib7 6564 8 lymphocyte lymphocyte NN cord-005453-4057qib7 6564 9 reactions reaction NNS cord-005453-4057qib7 6564 10 resulted result VBD cord-005453-4057qib7 6564 11 in in IN cord-005453-4057qib7 6564 12 a a DT cord-005453-4057qib7 6564 13 significantly significantly RB cord-005453-4057qib7 6564 14 reduced reduce VBN cord-005453-4057qib7 6564 15 activation activation NN cord-005453-4057qib7 6564 16 and and CC cord-005453-4057qib7 6564 17 proliferation proliferation NN cord-005453-4057qib7 6564 18 of of IN cord-005453-4057qib7 6564 19 MHC MHC NNP cord-005453-4057qib7 6564 20 - - HYPH cord-005453-4057qib7 6564 21 mismatched mismatch VBN cord-005453-4057qib7 6564 22 T t NN cord-005453-4057qib7 6564 23 cells cell NNS cord-005453-4057qib7 6564 24 . . . cord-005453-4057qib7 6565 1 Transwell Transwell NNP cord-005453-4057qib7 6565 2 assays assay NNS cord-005453-4057qib7 6565 3 and and CC cord-005453-4057qib7 6565 4 imaging image VBG cord-005453-4057qib7 6565 5 flow flow NN cord-005453-4057qib7 6565 6 cytometry cytometry NN cord-005453-4057qib7 6565 7 revealed reveal VBD cord-005453-4057qib7 6565 8 a a DT cord-005453-4057qib7 6565 9 cell cell NN cord-005453-4057qib7 6565 10 contactdependent contactdependent NN cord-005453-4057qib7 6565 11 mechanism mechanism NN cord-005453-4057qib7 6565 12 between between IN cord-005453-4057qib7 6565 13 iNKT inkt JJ cord-005453-4057qib7 6565 14 cells cell NNS cord-005453-4057qib7 6565 15 and and CC cord-005453-4057qib7 6565 16 DCs dc NNS cord-005453-4057qib7 6565 17 leading lead VBG cord-005453-4057qib7 6565 18 to to IN cord-005453-4057qib7 6565 19 apoptosis apoptosis NN cord-005453-4057qib7 6565 20 with with IN cord-005453-4057qib7 6565 21 increasing increase VBG cord-005453-4057qib7 6565 22 DNA dna NN cord-005453-4057qib7 6565 23 fragmentation fragmentation NN cord-005453-4057qib7 6565 24 of of IN cord-005453-4057qib7 6565 25 DCs DCs NNP cord-005453-4057qib7 6565 26 over over IN cord-005453-4057qib7 6565 27 time time NN cord-005453-4057qib7 6565 28 . . . cord-005453-4057qib7 6566 1 Interestingly interestingly RB cord-005453-4057qib7 6566 2 , , , cord-005453-4057qib7 6566 3 various various JJ cord-005453-4057qib7 6566 4 fluorescence fluorescence NN cord-005453-4057qib7 6566 5 - - HYPH cord-005453-4057qib7 6566 6 activated activate VBN cord-005453-4057qib7 6566 7 single single JJ cord-005453-4057qib7 6566 8 cell cell NN cord-005453-4057qib7 6566 9 sorted sort VBN cord-005453-4057qib7 6566 10 iNKT inkt JJ cord-005453-4057qib7 6566 11 - - HYPH cord-005453-4057qib7 6566 12 cell cell NN cord-005453-4057qib7 6566 13 subsets subset NNS cord-005453-4057qib7 6566 14 were be VBD cord-005453-4057qib7 6566 15 all all RB cord-005453-4057qib7 6566 16 able able JJ cord-005453-4057qib7 6566 17 to to TO cord-005453-4057qib7 6566 18 induce induce VB cord-005453-4057qib7 6566 19 apoptosis apoptosis NN cord-005453-4057qib7 6566 20 of of IN cord-005453-4057qib7 6566 21 host host NN cord-005453-4057qib7 6566 22 DCs DCs NNP cord-005453-4057qib7 6566 23 . . . cord-005453-4057qib7 6567 1 Multiplex multiplex NN cord-005453-4057qib7 6567 2 analysis analysis NN cord-005453-4057qib7 6567 3 revealed reveal VBD cord-005453-4057qib7 6567 4 that that IN cord-005453-4057qib7 6567 5 DCs DCs NNP cord-005453-4057qib7 6567 6 triggered trigger VBD cord-005453-4057qib7 6567 7 iNKT inkt JJ cord-005453-4057qib7 6567 8 - - HYPH cord-005453-4057qib7 6567 9 cell cell NN cord-005453-4057qib7 6567 10 release release NN cord-005453-4057qib7 6567 11 of of IN cord-005453-4057qib7 6567 12 cytotoxic cytotoxic JJ cord-005453-4057qib7 6567 13 factors factor NNS cord-005453-4057qib7 6567 14 like like IN cord-005453-4057qib7 6567 15 perforin perforin NNP cord-005453-4057qib7 6567 16 , , , cord-005453-4057qib7 6567 17 granzyme granzyme NNP cord-005453-4057qib7 6567 18 B B NNP cord-005453-4057qib7 6567 19 and and CC cord-005453-4057qib7 6567 20 granulysin granulysin NNP cord-005453-4057qib7 6567 21 . . . cord-005453-4057qib7 6568 1 Blocking block VBG cord-005453-4057qib7 6568 2 the the DT cord-005453-4057qib7 6568 3 iNKTcell iNKTcell NNP cord-005453-4057qib7 6568 4 receptor receptor NN cord-005453-4057qib7 6568 5 engagement engagement NN cord-005453-4057qib7 6568 6 with with IN cord-005453-4057qib7 6568 7 a a DT cord-005453-4057qib7 6568 8 CD1d CD1d NNP cord-005453-4057qib7 6568 9 antibody antibody NN cord-005453-4057qib7 6568 10 prevented prevent VBD cord-005453-4057qib7 6568 11 iNKT inkt JJ cord-005453-4057qib7 6568 12 - - HYPH cord-005453-4057qib7 6568 13 cell cell NN cord-005453-4057qib7 6568 14 degranulation degranulation NN cord-005453-4057qib7 6568 15 as as RB cord-005453-4057qib7 6568 16 well well RB cord-005453-4057qib7 6568 17 as as IN cord-005453-4057qib7 6568 18 the the DT cord-005453-4057qib7 6568 19 subsequent subsequent JJ cord-005453-4057qib7 6568 20 induction induction NN cord-005453-4057qib7 6568 21 of of IN cord-005453-4057qib7 6568 22 host host NN cord-005453-4057qib7 6568 23 DC DC NNP cord-005453-4057qib7 6568 24 apoptosis apoptosis NN cord-005453-4057qib7 6568 25 . . . cord-005453-4057qib7 6569 1 Inhibition inhibition NN cord-005453-4057qib7 6569 2 of of IN cord-005453-4057qib7 6569 3 cytotoxic cytotoxic JJ cord-005453-4057qib7 6569 4 factors factor NNS cord-005453-4057qib7 6569 5 also also RB cord-005453-4057qib7 6569 6 abrogated abrogate VBD cord-005453-4057qib7 6569 7 apoptosis apoptosis NN cord-005453-4057qib7 6569 8 of of IN cord-005453-4057qib7 6569 9 DCs dc NNS cord-005453-4057qib7 6569 10 . . . cord-005453-4057qib7 6570 1 In in IN cord-005453-4057qib7 6570 2 turn turn NN cord-005453-4057qib7 6570 3 , , , cord-005453-4057qib7 6570 4 sorted sort VBD cord-005453-4057qib7 6570 5 apoptotic apoptotic JJ cord-005453-4057qib7 6570 6 DCs dc NNS cord-005453-4057qib7 6570 7 induced induce VBD cord-005453-4057qib7 6570 8 tolerogenic tolerogenic NNP cord-005453-4057qib7 6570 9 DCs DCs NNP cord-005453-4057qib7 6570 10 characterized characterize VBN cord-005453-4057qib7 6570 11 by by IN cord-005453-4057qib7 6570 12 a a DT cord-005453-4057qib7 6570 13 high high JJ cord-005453-4057qib7 6570 14 expression expression NN cord-005453-4057qib7 6570 15 of of IN cord-005453-4057qib7 6570 16 PD PD NNP cord-005453-4057qib7 6570 17 - - HYPH cord-005453-4057qib7 6570 18 L1 L1 NNP cord-005453-4057qib7 6570 19 in in IN cord-005453-4057qib7 6570 20 mixed mixed JJ cord-005453-4057qib7 6570 21 lymphocyte lymphocyte NN cord-005453-4057qib7 6570 22 reactions reaction NNS cord-005453-4057qib7 6570 23 . . . cord-005453-4057qib7 6571 1 Such such JJ cord-005453-4057qib7 6571 2 tolerogenic tolerogenic JJ cord-005453-4057qib7 6571 3 DCs dc NNS cord-005453-4057qib7 6571 4 promoted promote VBD cord-005453-4057qib7 6571 5 the the DT cord-005453-4057qib7 6571 6 expansion expansion NN cord-005453-4057qib7 6571 7 of of IN cord-005453-4057qib7 6571 8 CD4 CD4 NNP cord-005453-4057qib7 6571 9 + + CC cord-005453-4057qib7 6571 10 CD25 CD25 NNP cord-005453-4057qib7 6571 11 + + CC cord-005453-4057qib7 6571 12 FoxP3 FoxP3 NNP cord-005453-4057qib7 6571 13 + + CC cord-005453-4057qib7 6571 14 Tregs Tregs NNP cord-005453-4057qib7 6571 15 and and CC cord-005453-4057qib7 6571 16 prevented prevent VBD cord-005453-4057qib7 6571 17 activation activation NN cord-005453-4057qib7 6571 18 and and CC cord-005453-4057qib7 6571 19 proliferation proliferation NN cord-005453-4057qib7 6571 20 of of IN cord-005453-4057qib7 6571 21 MHCmismatched mhcmismatched JJ cord-005453-4057qib7 6571 22 T t NN cord-005453-4057qib7 6571 23 cells cell NNS cord-005453-4057qib7 6571 24 . . . cord-005453-4057qib7 6572 1 Conclusions conclusion NNS cord-005453-4057qib7 6572 2 : : : cord-005453-4057qib7 6573 1 We -PRON- PRP cord-005453-4057qib7 6573 2 propose propose VBP cord-005453-4057qib7 6573 3 a a DT cord-005453-4057qib7 6573 4 novel novel JJ cord-005453-4057qib7 6573 5 mechanism mechanism NN cord-005453-4057qib7 6573 6 how how WRB cord-005453-4057qib7 6573 7 culture culture NN cord-005453-4057qib7 6573 8 - - HYPH cord-005453-4057qib7 6573 9 expanded expand VBN cord-005453-4057qib7 6573 10 human human JJ cord-005453-4057qib7 6573 11 iNKT inkt JJ cord-005453-4057qib7 6573 12 cells cell NNS cord-005453-4057qib7 6573 13 prevent prevent VBP cord-005453-4057qib7 6573 14 GVHD GVHD NNP cord-005453-4057qib7 6573 15 after after IN cord-005453-4057qib7 6573 16 allogeneic allogeneic NN cord-005453-4057qib7 6573 17 HCT hct NN cord-005453-4057qib7 6573 18 . . . cord-005453-4057qib7 6574 1 Host host NN cord-005453-4057qib7 6574 2 DC DC NNP cord-005453-4057qib7 6574 3 apoptosis apoptosis NN cord-005453-4057qib7 6574 4 through through IN cord-005453-4057qib7 6574 5 donor donor NN cord-005453-4057qib7 6574 6 iNKT inkt NN cord-005453-4057qib7 6574 7 cells cell NNS cord-005453-4057qib7 6574 8 induces induce VBZ cord-005453-4057qib7 6574 9 a a DT cord-005453-4057qib7 6574 10 tolerogenic tolerogenic NNP cord-005453-4057qib7 6574 11 immunoenvironment immunoenvironment NN cord-005453-4057qib7 6574 12 characterized characterize VBN cord-005453-4057qib7 6574 13 by by IN cord-005453-4057qib7 6574 14 PD PD NNP cord-005453-4057qib7 6574 15 - - HYPH cord-005453-4057qib7 6574 16 L1 L1 NNP cord-005453-4057qib7 6574 17 high high JJ cord-005453-4057qib7 6574 18 DCs dc NNS cord-005453-4057qib7 6574 19 and and CC cord-005453-4057qib7 6574 20 expanding expand VBG cord-005453-4057qib7 6574 21 donor donor NN cord-005453-4057qib7 6574 22 Tregs Tregs NNP cord-005453-4057qib7 6574 23 inhibiting inhibit VBG cord-005453-4057qib7 6574 24 activation activation NN cord-005453-4057qib7 6574 25 and and CC cord-005453-4057qib7 6574 26 expansion expansion NN cord-005453-4057qib7 6574 27 of of IN cord-005453-4057qib7 6574 28 alloreactive alloreactive JJ cord-005453-4057qib7 6574 29 donor donor NN cord-005453-4057qib7 6574 30 T t NN cord-005453-4057qib7 6574 31 cells cell NNS cord-005453-4057qib7 6574 32 . . . cord-005453-4057qib7 6575 1 Our -PRON- PRP$ cord-005453-4057qib7 6575 2 findings finding NNS cord-005453-4057qib7 6575 3 pave pave VBP cord-005453-4057qib7 6575 4 the the DT cord-005453-4057qib7 6575 5 avenue avenue NN cord-005453-4057qib7 6575 6 for for IN cord-005453-4057qib7 6575 7 clinical clinical JJ cord-005453-4057qib7 6575 8 translation translation NN cord-005453-4057qib7 6575 9 of of IN cord-005453-4057qib7 6575 10 adoptively adoptively RB cord-005453-4057qib7 6575 11 transferred transfer VBN cord-005453-4057qib7 6575 12 culture culture NN cord-005453-4057qib7 6575 13 - - HYPH cord-005453-4057qib7 6575 14 expanded expand VBN cord-005453-4057qib7 6575 15 iNKT inkt JJ cord-005453-4057qib7 6575 16 cells cell NNS cord-005453-4057qib7 6575 17 in in IN cord-005453-4057qib7 6575 18 humans human NNS cord-005453-4057qib7 6575 19 . . . cord-005453-4057qib7 6576 1 Disclosure disclosure NN cord-005453-4057qib7 6576 2 : : : cord-005453-4057qib7 6576 3 Nothing nothing NN cord-005453-4057qib7 6576 4 to to TO cord-005453-4057qib7 6576 5 declare declare VB cord-005453-4057qib7 6576 6 Results result NNS cord-005453-4057qib7 6576 7 : : : cord-005453-4057qib7 6576 8 VIP VIP NNP cord-005453-4057qib7 6576 9 - - HYPH cord-005453-4057qib7 6576 10 KO KO NNP cord-005453-4057qib7 6576 11 mice mouse NNS cord-005453-4057qib7 6576 12 transplanted transplant VBN cord-005453-4057qib7 6576 13 with with IN cord-005453-4057qib7 6576 14 allogeneic allogeneic NN cord-005453-4057qib7 6576 15 TCD TCD NNP cord-005453-4057qib7 6576 16 BM BM NNP cord-005453-4057qib7 6576 17 alone alone RB cord-005453-4057qib7 6576 18 had have VBD cord-005453-4057qib7 6576 19 increased increase VBN cord-005453-4057qib7 6576 20 graft graft NN cord-005453-4057qib7 6576 21 rejection rejection NN cord-005453-4057qib7 6576 22 with with IN cord-005453-4057qib7 6576 23 lower low JJR cord-005453-4057qib7 6576 24 levels level NNS cord-005453-4057qib7 6576 25 of of IN cord-005453-4057qib7 6576 26 donor donor NN cord-005453-4057qib7 6576 27 chimerism chimerism NN cord-005453-4057qib7 6576 28 and and CC cord-005453-4057qib7 6576 29 33 33 CD cord-005453-4057qib7 6576 30 % % NN cord-005453-4057qib7 6576 31 day day NN cord-005453-4057qib7 6576 32 75 75 CD cord-005453-4057qib7 6576 33 survival survival NN cord-005453-4057qib7 6576 34 compared compare VBN cord-005453-4057qib7 6576 35 with with IN cord-005453-4057qib7 6576 36 73 73 CD cord-005453-4057qib7 6576 37 % % NN cord-005453-4057qib7 6576 38 survival survival NN cord-005453-4057qib7 6576 39 of of IN cord-005453-4057qib7 6576 40 WT WT NNP cord-005453-4057qib7 6576 41 recipients recipient NNS cord-005453-4057qib7 6576 42 . . . cord-005453-4057qib7 6577 1 Transplanting transplant VBG cord-005453-4057qib7 6577 2 TCD TCD NNP cord-005453-4057qib7 6577 3 BM BM NNP cord-005453-4057qib7 6577 4 plus plus CC cord-005453-4057qib7 6577 5 3 3 CD cord-005453-4057qib7 6577 6 × × NN cord-005453-4057qib7 6577 7 10E6 10e6 CD cord-005453-4057qib7 6577 8 donor donor NN cord-005453-4057qib7 6577 9 T t NN cord-005453-4057qib7 6577 10 cells cell NNS cord-005453-4057qib7 6577 11 from from IN cord-005453-4057qib7 6577 12 B10.BR B10.BR NNS cord-005453-4057qib7 6578 1 or or CC cord-005453-4057qib7 6578 2 Balb Balb NNP cord-005453-4057qib7 6578 3 / / SYM cord-005453-4057qib7 6578 4 c c NN cord-005453-4057qib7 6578 5 donors donor NNS cord-005453-4057qib7 6578 6 in in IN cord-005453-4057qib7 6578 7 VIP VIP NNP cord-005453-4057qib7 6578 8 KIO KIO NNP cord-005453-4057qib7 6578 9 mice mouse NNS cord-005453-4057qib7 6578 10 led lead VBD cord-005453-4057qib7 6578 11 to to IN cord-005453-4057qib7 6578 12 > > XX cord-005453-4057qib7 6578 13 95 95 CD cord-005453-4057qib7 6578 14 % % NN cord-005453-4057qib7 6578 15 donor donor NN cord-005453-4057qib7 6578 16 chimerism chimerism NN cord-005453-4057qib7 6578 17 and and CC cord-005453-4057qib7 6578 18 significantly significantly RB cord-005453-4057qib7 6578 19 increased increase VBN cord-005453-4057qib7 6578 20 GVHD GVHD NNP cord-005453-4057qib7 6578 21 - - HYPH cord-005453-4057qib7 6578 22 mortality mortality NN cord-005453-4057qib7 6578 23 compared compare VBN cord-005453-4057qib7 6578 24 with with IN cord-005453-4057qib7 6578 25 WT WT NNP cord-005453-4057qib7 6578 26 recipients recipient NNS cord-005453-4057qib7 6578 27 , , , cord-005453-4057qib7 6578 28 with with IN cord-005453-4057qib7 6578 29 0 0 CD cord-005453-4057qib7 6578 30 % % NN cord-005453-4057qib7 6578 31 vs vs IN cord-005453-4057qib7 6578 32 40 40 CD cord-005453-4057qib7 6578 33 % % NN cord-005453-4057qib7 6578 34 survival survival NN cord-005453-4057qib7 6578 35 in in IN cord-005453-4057qib7 6578 36 the the DT cord-005453-4057qib7 6578 37 B10.BR-->B6 b10.br-->b6 JJ cord-005453-4057qib7 6578 38 model model NN cord-005453-4057qib7 6578 39 ( ( -LRB- cord-005453-4057qib7 6578 40 p p NN cord-005453-4057qib7 6578 41 < < XX cord-005453-4057qib7 6578 42 0.01 0.01 CD cord-005453-4057qib7 6578 43 ) ) -RRB- cord-005453-4057qib7 6578 44 , , , cord-005453-4057qib7 6578 45 and and CC cord-005453-4057qib7 6578 46 0 0 CD cord-005453-4057qib7 6578 47 % % NN cord-005453-4057qib7 6578 48 vs vs IN cord-005453-4057qib7 6578 49 73 73 CD cord-005453-4057qib7 6578 50 % % NN cord-005453-4057qib7 6578 51 survival survival NN cord-005453-4057qib7 6578 52 in in IN cord-005453-4057qib7 6578 53 the the DT cord-005453-4057qib7 6578 54 Balb Balb NNP cord-005453-4057qib7 6578 55 / / SYM cord-005453-4057qib7 6578 56 c-->B6 c-->b6 NN cord-005453-4057qib7 6578 57 model model NN cord-005453-4057qib7 6578 58 ( ( -LRB- cord-005453-4057qib7 6578 59 P p NN cord-005453-4057qib7 6578 60 < < XX cord-005453-4057qib7 6578 61 0.01 0.01 CD cord-005453-4057qib7 6578 62 ) ) -RRB- cord-005453-4057qib7 6578 63 . . . cord-005453-4057qib7 6579 1 Donor donor NN cord-005453-4057qib7 6579 2 - - HYPH cord-005453-4057qib7 6579 3 derived derive VBN cord-005453-4057qib7 6579 4 T t NN cord-005453-4057qib7 6579 5 cells cell NNS cord-005453-4057qib7 6579 6 in in IN cord-005453-4057qib7 6579 7 VIP VIP NNP cord-005453-4057qib7 6579 8 - - HYPH cord-005453-4057qib7 6579 9 KO KO NNP cord-005453-4057qib7 6579 10 recipients recipient NNS cord-005453-4057qib7 6579 11 had have VBD cord-005453-4057qib7 6579 12 significantly significantly RB cord-005453-4057qib7 6579 13 higher high JJR cord-005453-4057qib7 6579 14 Th1 th1 NN cord-005453-4057qib7 6579 15 and and CC cord-005453-4057qib7 6579 16 Th17 th17 CD cord-005453-4057qib7 6579 17 polarization polarization NN cord-005453-4057qib7 6579 18 , , , cord-005453-4057qib7 6579 19 with with IN cord-005453-4057qib7 6579 20 higher high JJR cord-005453-4057qib7 6579 21 RORγt RORγt NNP cord-005453-4057qib7 6579 22 in in IN cord-005453-4057qib7 6579 23 both both DT cord-005453-4057qib7 6579 24 CD4 CD4 NNP cord-005453-4057qib7 6579 25 + + CC cord-005453-4057qib7 6579 26 ( ( -LRB- cord-005453-4057qib7 6579 27 p p NN cord-005453-4057qib7 6579 28 < < XX cord-005453-4057qib7 6579 29 0.0001 0.0001 CD cord-005453-4057qib7 6579 30 ) ) -RRB- cord-005453-4057qib7 6579 31 and and CC cord-005453-4057qib7 6579 32 CD8 CD8 NNP cord-005453-4057qib7 6579 33 + + CC cord-005453-4057qib7 6579 34 ( ( -LRB- cord-005453-4057qib7 6579 35 p p NN cord-005453-4057qib7 6579 36 < < XX cord-005453-4057qib7 6579 37 0.0001 0.0001 CD cord-005453-4057qib7 6579 38 ) ) -RRB- cord-005453-4057qib7 6579 39 T t NN cord-005453-4057qib7 6579 40 cells cell NNS cord-005453-4057qib7 6579 41 , , , cord-005453-4057qib7 6579 42 and and CC cord-005453-4057qib7 6579 43 higher high JJR cord-005453-4057qib7 6579 44 frequencies frequency NNS cord-005453-4057qib7 6579 45 of of IN cord-005453-4057qib7 6579 46 IFN IFN NNP cord-005453-4057qib7 6579 47 - - HYPH cord-005453-4057qib7 6579 48 γ γ NNP cord-005453-4057qib7 6579 49 ( ( -LRB- cord-005453-4057qib7 6579 50 p p NN cord-005453-4057qib7 6579 51 < < XX cord-005453-4057qib7 6579 52 0.001 0.001 CD cord-005453-4057qib7 6579 53 ) ) -RRB- cord-005453-4057qib7 6579 54 , , , cord-005453-4057qib7 6579 55 TNF TNF NNP cord-005453-4057qib7 6579 56 - - HYPH cord-005453-4057qib7 6579 57 α α NNP cord-005453-4057qib7 6579 58 ( ( -LRB- cord-005453-4057qib7 6579 59 p p NN cord-005453-4057qib7 6579 60 < < XX cord-005453-4057qib7 6579 61 0.05 0.05 CD cord-005453-4057qib7 6579 62 ) ) -RRB- cord-005453-4057qib7 6579 63 , , , cord-005453-4057qib7 6579 64 and and CC cord-005453-4057qib7 6579 65 IL2 IL2 NNP cord-005453-4057qib7 6579 66 ( ( -LRB- cord-005453-4057qib7 6579 67 p p NN cord-005453-4057qib7 6579 68 < < XX cord-005453-4057qib7 6579 69 0.01 0.01 CD cord-005453-4057qib7 6579 70 ) ) -RRB- cord-005453-4057qib7 6579 71 in in IN cord-005453-4057qib7 6579 72 CD4 CD4 NNP cord-005453-4057qib7 6579 73 + + CC cord-005453-4057qib7 6579 74 and and CC cord-005453-4057qib7 6579 75 CD8 CD8 NNP cord-005453-4057qib7 6579 76 + + CC cord-005453-4057qib7 6579 77 T t NN cord-005453-4057qib7 6579 78 cells cell NNS cord-005453-4057qib7 6579 79 compared compare VBN cord-005453-4057qib7 6579 80 to to IN cord-005453-4057qib7 6579 81 WT WT NNP cord-005453-4057qib7 6579 82 recipients recipient NNS cord-005453-4057qib7 6579 83 . . . cord-005453-4057qib7 6580 1 B10.BR-->B6 b10.br-->b6 JJ cord-005453-4057qib7 6580 2 second second JJ cord-005453-4057qib7 6580 3 allogeneic allogeneic NN cord-005453-4057qib7 6580 4 transplantation transplantation NN cord-005453-4057qib7 6580 5 of of IN cord-005453-4057qib7 6580 6 radiation radiation NN cord-005453-4057qib7 6580 7 chimeras chimera NNS cord-005453-4057qib7 6580 8 caused cause VBD cord-005453-4057qib7 6580 9 lethal lethal JJ cord-005453-4057qib7 6580 10 GVHD GVHD NNP cord-005453-4057qib7 6580 11 mortality mortality NN cord-005453-4057qib7 6580 12 in in IN cord-005453-4057qib7 6580 13 VIP vip NN cord-005453-4057qib7 6580 14 - - HYPH cord-005453-4057qib7 6580 15 KO-->VIP ko-->vip NN cord-005453-4057qib7 6580 16 - - HYPH cord-005453-4057qib7 6580 17 KO KO NNP cord-005453-4057qib7 6580 18 and and CC cord-005453-4057qib7 6580 19 WT-->VIP WT-->VIP NNP cord-005453-4057qib7 6580 20 - - HYPH cord-005453-4057qib7 6580 21 KO KO NNP cord-005453-4057qib7 6580 22 mice mouse NNS cord-005453-4057qib7 6580 23 , , , cord-005453-4057qib7 6580 24 but but CC cord-005453-4057qib7 6580 25 not not RB cord-005453-4057qib7 6580 26 in in IN cord-005453-4057qib7 6580 27 WT-->WT wt-->wt CD cord-005453-4057qib7 6580 28 or or CC cord-005453-4057qib7 6580 29 VIP vip NN cord-005453-4057qib7 6580 30 - - HYPH cord-005453-4057qib7 6580 31 KO-->WT ko-->wt CD cord-005453-4057qib7 6580 32 B6 b6 NN cord-005453-4057qib7 6580 33 mice mouse NNS cord-005453-4057qib7 6580 34 , , , cord-005453-4057qib7 6580 35 demonstrating demonstrate VBG cord-005453-4057qib7 6580 36 the the DT cord-005453-4057qib7 6580 37 protective protective JJ cord-005453-4057qib7 6580 38 effect effect NN cord-005453-4057qib7 6580 39 of of IN cord-005453-4057qib7 6580 40 VIP VIP NNP cord-005453-4057qib7 6580 41 was be VBD cord-005453-4057qib7 6580 42 due due JJ cord-005453-4057qib7 6580 43 to to IN cord-005453-4057qib7 6580 44 synthesis synthesis NN cord-005453-4057qib7 6580 45 by by IN cord-005453-4057qib7 6580 46 non non JJ cord-005453-4057qib7 6580 47 - - JJ cord-005453-4057qib7 6580 48 hematopoietic hematopoietic JJ cord-005453-4057qib7 6580 49 recipient recipient NN cord-005453-4057qib7 6580 50 cells cell NNS cord-005453-4057qib7 6580 51 . . . cord-005453-4057qib7 6581 1 Immunofluorescent Immunofluorescent NNP cord-005453-4057qib7 6581 2 imaging imaging NN cord-005453-4057qib7 6581 3 of of IN cord-005453-4057qib7 6581 4 allo allo NN cord-005453-4057qib7 6581 5 - - HYPH cord-005453-4057qib7 6581 6 BMT BMT NNP cord-005453-4057qib7 6581 7 recipients recipient NNS cord-005453-4057qib7 6581 8 showed show VBD cord-005453-4057qib7 6581 9 marked mark VBN cord-005453-4057qib7 6581 10 up up JJ cord-005453-4057qib7 6581 11 - - HYPH cord-005453-4057qib7 6581 12 regulation regulation NN cord-005453-4057qib7 6581 13 of of IN cord-005453-4057qib7 6581 14 VIP vip NN cord-005453-4057qib7 6581 15 in in IN cord-005453-4057qib7 6581 16 lungs lung NNS cord-005453-4057qib7 6581 17 post post JJ cord-005453-4057qib7 6581 18 - - JJ cord-005453-4057qib7 6581 19 transplant transplant JJ cord-005453-4057qib7 6581 20 and and CC cord-005453-4057qib7 6581 21 high high JJ cord-005453-4057qib7 6581 22 VIP vip NN cord-005453-4057qib7 6581 23 production production NN cord-005453-4057qib7 6581 24 within within IN cord-005453-4057qib7 6581 25 neurons neuron NNS cord-005453-4057qib7 6581 26 innervating innervate VBG cord-005453-4057qib7 6581 27 the the DT cord-005453-4057qib7 6581 28 lungs lung NNS cord-005453-4057qib7 6581 29 . . . cord-005453-4057qib7 6582 1 Finally finally RB cord-005453-4057qib7 6582 2 , , , cord-005453-4057qib7 6582 3 we -PRON- PRP cord-005453-4057qib7 6582 4 demonstrated demonstrate VBD cord-005453-4057qib7 6582 5 that that IN cord-005453-4057qib7 6582 6 short short JJ cord-005453-4057qib7 6582 7 - - HYPH cord-005453-4057qib7 6582 8 term term NN cord-005453-4057qib7 6582 9 administration administration NN cord-005453-4057qib7 6582 10 of of IN cord-005453-4057qib7 6582 11 VIP VIP NNP cord-005453-4057qib7 6582 12 ( ( -LRB- cord-005453-4057qib7 6582 13 10mcg 10mcg NNP cord-005453-4057qib7 6582 14 / / SYM cord-005453-4057qib7 6582 15 day day NN cord-005453-4057qib7 6582 16 ) ) -RRB- cord-005453-4057qib7 6582 17 from from IN cord-005453-4057qib7 6582 18 day day NN cord-005453-4057qib7 6582 19 0 0 CD cord-005453-4057qib7 6582 20 to to IN cord-005453-4057qib7 6582 21 day day NN cord-005453-4057qib7 6582 22 10 10 CD cord-005453-4057qib7 6582 23 prevented prevent VBD cord-005453-4057qib7 6582 24 GvHDmortality GvHDmortality NNP cord-005453-4057qib7 6582 25 in in IN cord-005453-4057qib7 6582 26 VIP VIP NNP cord-005453-4057qib7 6582 27 - - HYPH cord-005453-4057qib7 6582 28 KO KO NNP cord-005453-4057qib7 6582 29 recipients recipient NNS cord-005453-4057qib7 6582 30 transplanted transplant VBN cord-005453-4057qib7 6582 31 with with IN cord-005453-4057qib7 6582 32 B10.BR-->B6 B10.BR-->B6 NNP cord-005453-4057qib7 6582 33 MHC MHC NNP cord-005453-4057qib7 6582 34 donor donor NN cord-005453-4057qib7 6582 35 BM BM NNP cord-005453-4057qib7 6582 36 & & CC cord-005453-4057qib7 6582 37 T T NNP cord-005453-4057qib7 6582 38 cells cell NNS cord-005453-4057qib7 6582 39 . . . cord-005453-4057qib7 6583 1 Conclusions conclusion NNS cord-005453-4057qib7 6583 2 : : : cord-005453-4057qib7 6584 1 The the DT cord-005453-4057qib7 6584 2 absence absence NN cord-005453-4057qib7 6584 3 of of IN cord-005453-4057qib7 6584 4 VIP vip NN cord-005453-4057qib7 6584 5 in in IN cord-005453-4057qib7 6584 6 recipient recipient NN cord-005453-4057qib7 6584 7 cells cell NNS cord-005453-4057qib7 6584 8 led lead VBD cord-005453-4057qib7 6584 9 to to IN cord-005453-4057qib7 6584 10 increased increase VBN cord-005453-4057qib7 6584 11 graft graft NN cord-005453-4057qib7 6584 12 rejection rejection NN cord-005453-4057qib7 6584 13 in in IN cord-005453-4057qib7 6584 14 the the DT cord-005453-4057qib7 6584 15 absence absence NN cord-005453-4057qib7 6584 16 of of IN cord-005453-4057qib7 6584 17 donor donor NN cord-005453-4057qib7 6584 18 T t NN cord-005453-4057qib7 6584 19 cells cell NNS cord-005453-4057qib7 6584 20 and and CC cord-005453-4057qib7 6584 21 increased increase VBN cord-005453-4057qib7 6584 22 lethal lethal JJ cord-005453-4057qib7 6584 23 GVHD gvhd NN cord-005453-4057qib7 6584 24 when when WRB cord-005453-4057qib7 6584 25 donor donor NN cord-005453-4057qib7 6584 26 T t NN cord-005453-4057qib7 6584 27 cells cell NNS cord-005453-4057qib7 6584 28 were be VBD cord-005453-4057qib7 6584 29 transplanted transplant VBN cord-005453-4057qib7 6584 30 , , , cord-005453-4057qib7 6584 31 indicating indicate VBG cord-005453-4057qib7 6584 32 VIP vip NN cord-005453-4057qib7 6584 33 induced induce VBN cord-005453-4057qib7 6584 34 post post JJ cord-005453-4057qib7 6584 35 - - JJ cord-005453-4057qib7 6584 36 transplant transplant JJ cord-005453-4057qib7 6584 37 regulates regulate VBZ cord-005453-4057qib7 6584 38 allo allo NN cord-005453-4057qib7 6584 39 - - HYPH cord-005453-4057qib7 6584 40 reactivity reactivity NN cord-005453-4057qib7 6584 41 of of IN cord-005453-4057qib7 6584 42 host host NN cord-005453-4057qib7 6584 43 graft graft NN cord-005453-4057qib7 6584 44 - - HYPH cord-005453-4057qib7 6584 45 rejecting reject VBG cord-005453-4057qib7 6584 46 lymphocytes lymphocyte NNS cord-005453-4057qib7 6584 47 and and CC cord-005453-4057qib7 6584 48 donor donor NN cord-005453-4057qib7 6585 1 GVHD GVHD NNP cord-005453-4057qib7 6585 2 - - HYPH cord-005453-4057qib7 6585 3 causing cause VBG cord-005453-4057qib7 6585 4 T t NN cord-005453-4057qib7 6585 5 cells cell NNS cord-005453-4057qib7 6585 6 . . . cord-005453-4057qib7 6586 1 The the DT cord-005453-4057qib7 6586 2 protective protective JJ cord-005453-4057qib7 6586 3 effect effect NN cord-005453-4057qib7 6586 4 of of IN cord-005453-4057qib7 6586 5 parenteral parenteral JJ cord-005453-4057qib7 6586 6 VIP VIP NNP cord-005453-4057qib7 6586 7 administration administration NN cord-005453-4057qib7 6586 8 suggests suggest VBZ cord-005453-4057qib7 6586 9 VIP vip NN cord-005453-4057qib7 6586 10 - - HYPH cord-005453-4057qib7 6586 11 mimetics mimetic NNS cord-005453-4057qib7 6586 12 represent represent VBP cord-005453-4057qib7 6586 13 a a DT cord-005453-4057qib7 6586 14 novel novel JJ cord-005453-4057qib7 6586 15 approach approach NN cord-005453-4057qib7 6586 16 to to TO cord-005453-4057qib7 6586 17 prevent prevent VB cord-005453-4057qib7 6586 18 and and CC cord-005453-4057qib7 6586 19 treat treat VB cord-005453-4057qib7 6586 20 GVHD GVHD NNP cord-005453-4057qib7 6586 21 . . . cord-005453-4057qib7 6587 1 These these DT cord-005453-4057qib7 6587 2 data datum NNS cord-005453-4057qib7 6587 3 also also RB cord-005453-4057qib7 6587 4 suggest suggest VBP cord-005453-4057qib7 6587 5 a a DT cord-005453-4057qib7 6587 6 mechanism mechanism NN cord-005453-4057qib7 6587 7 of of IN cord-005453-4057qib7 6587 8 action action NN cord-005453-4057qib7 6587 9 for for IN cord-005453-4057qib7 6587 10 the the DT cord-005453-4057qib7 6587 11 mitigation mitigation NN cord-005453-4057qib7 6587 12 of of IN cord-005453-4057qib7 6587 13 GvHD GvHD NNP cord-005453-4057qib7 6587 14 by by IN cord-005453-4057qib7 6587 15 alpha-1 alpha-1 NNP cord-005453-4057qib7 6587 16 anti anti JJ cord-005453-4057qib7 6587 17 - - JJ cord-005453-4057qib7 6587 18 trypsin trypsin JJ cord-005453-4057qib7 6587 19 ( ( -LRB- cord-005453-4057qib7 6587 20 AAT AAT NNP cord-005453-4057qib7 6587 21 ) ) -RRB- cord-005453-4057qib7 6587 22 whereby whereby WRB cord-005453-4057qib7 6587 23 AAT AAT NNP cord-005453-4057qib7 6587 24 inhibits inhibit VBZ cord-005453-4057qib7 6587 25 the the DT cord-005453-4057qib7 6587 26 proteolytic proteolytic JJ cord-005453-4057qib7 6587 27 inactivation inactivation NN cord-005453-4057qib7 6587 28 of of IN cord-005453-4057qib7 6587 29 endogenous endogenous JJ cord-005453-4057qib7 6587 30 VIP vip NN cord-005453-4057qib7 6587 31 . . . cord-005453-4057qib7 6588 1 Disclosure disclosure NN cord-005453-4057qib7 6588 2 : : : cord-005453-4057qib7 6588 3 Dr. Dr. NNP cord-005453-4057qib7 6588 4 Waller Waller NNP cord-005453-4057qib7 6588 5 reports report VBZ cord-005453-4057qib7 6588 6 personal personal JJ cord-005453-4057qib7 6588 7 fees fee NNS cord-005453-4057qib7 6588 8 and and CC cord-005453-4057qib7 6588 9 other other JJ cord-005453-4057qib7 6588 10 support support NN cord-005453-4057qib7 6588 11 from from IN cord-005453-4057qib7 6588 12 Cambium Cambium NNP cord-005453-4057qib7 6588 13 Medical Medical NNP cord-005453-4057qib7 6588 14 Technologies Technologies NNPS cord-005453-4057qib7 6588 15 , , , cord-005453-4057qib7 6588 16 grants grant NNS cord-005453-4057qib7 6588 17 from from IN cord-005453-4057qib7 6588 18 Celldex Celldex NNP cord-005453-4057qib7 6588 19 , , , cord-005453-4057qib7 6588 20 personal personal JJ cord-005453-4057qib7 6588 21 fees fee NNS cord-005453-4057qib7 6588 22 from from IN cord-005453-4057qib7 6588 23 Kalytera Kalytera NNP cord-005453-4057qib7 6588 24 , , , cord-005453-4057qib7 6588 25 grants grant NNS cord-005453-4057qib7 6588 26 and and CC cord-005453-4057qib7 6588 27 personal personal JJ cord-005453-4057qib7 6588 28 fees fee NNS cord-005453-4057qib7 6588 29 from from IN cord-005453-4057qib7 6588 30 Novartis Novartis NNP cord-005453-4057qib7 6588 31 , , , cord-005453-4057qib7 6588 32 grants grant NNS cord-005453-4057qib7 6588 33 and and CC cord-005453-4057qib7 6588 34 non non JJ cord-005453-4057qib7 6588 35 - - JJ cord-005453-4057qib7 6588 36 financial financial JJ cord-005453-4057qib7 6588 37 support support NN cord-005453-4057qib7 6588 38 from from IN cord-005453-4057qib7 6588 39 Pharmacyclics Pharmacyclics NNP cord-005453-4057qib7 6588 40 , , , cord-005453-4057qib7 6588 41 and and CC cord-005453-4057qib7 6588 42 equity equity NN cord-005453-4057qib7 6588 43 ownership ownership NN cord-005453-4057qib7 6588 44 in in IN cord-005453-4057qib7 6588 45 Cerus Cerus NNP cord-005453-4057qib7 6588 46 Corporation Corporation NNP cord-005453-4057qib7 6588 47 and and CC cord-005453-4057qib7 6588 48 Chimerix Chimerix NNP cord-005453-4057qib7 6588 49 outside outside IN cord-005453-4057qib7 6588 50 the the DT cord-005453-4057qib7 6588 51 submitted submit VBN cord-005453-4057qib7 6588 52 work work NN cord-005453-4057qib7 6588 53 . . . cord-005453-4057qib7 6589 1 In in IN cord-005453-4057qib7 6589 2 addition addition NN cord-005453-4057qib7 6589 3 , , , cord-005453-4057qib7 6589 4 Dr. Dr. NNP cord-005453-4057qib7 6589 5 Waller Waller NNP cord-005453-4057qib7 6589 6 has have VBZ cord-005453-4057qib7 6589 7 intellectual intellectual JJ cord-005453-4057qib7 6589 8 property property NN cord-005453-4057qib7 6589 9 related relate VBN cord-005453-4057qib7 6589 10 to to IN cord-005453-4057qib7 6589 11 VIP vip NN cord-005453-4057qib7 6589 12 signaling signaling NN cord-005453-4057qib7 6589 13 that that WDT cord-005453-4057qib7 6589 14 has have VBZ cord-005453-4057qib7 6589 15 been be VBN cord-005453-4057qib7 6589 16 licensed license VBN cord-005453-4057qib7 6589 17 to to IN cord-005453-4057qib7 6589 18 Cambium Cambium NNP cord-005453-4057qib7 6589 19 Oncology Oncology NNP cord-005453-4057qib7 6589 20 in in IN cord-005453-4057qib7 6589 21 which which WDT cord-005453-4057qib7 6589 22 he -PRON- PRP cord-005453-4057qib7 6589 23 holds hold VBZ cord-005453-4057qib7 6589 24 equity equity NN cord-005453-4057qib7 6589 25 . . . cord-005453-4057qib7 6590 1 Low low JJ cord-005453-4057qib7 6590 2 - - HYPH cord-005453-4057qib7 6590 3 density density NN cord-005453-4057qib7 6590 4 neutrophils neutrophil NNS cord-005453-4057qib7 6590 5 expansion expansion NN cord-005453-4057qib7 6590 6 is be VBZ cord-005453-4057qib7 6590 7 associated associate VBN cord-005453-4057qib7 6590 8 with with IN cord-005453-4057qib7 6590 9 acute acute JJ cord-005453-4057qib7 6590 10 graft graft NN cord-005453-4057qib7 6590 11 versus versus IN cord-005453-4057qib7 6590 12 host host NN cord-005453-4057qib7 6590 13 disease disease NN cord-005453-4057qib7 6590 14 in in IN cord-005453-4057qib7 6590 15 allogeneic allogeneic JJ cord-005453-4057qib7 6590 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 6590 17 stem stem NN cord-005453-4057qib7 6590 18 cell cell NN cord-005453-4057qib7 6590 19 transplant transplant NN cord-005453-4057qib7 6590 20 patients patient NNS cord-005453-4057qib7 6591 1 Background background NN cord-005453-4057qib7 6591 2 : : : cord-005453-4057qib7 6591 3 Low low JJ cord-005453-4057qib7 6591 4 - - HYPH cord-005453-4057qib7 6591 5 density density NN cord-005453-4057qib7 6591 6 neutrophils neutrophil NNS cord-005453-4057qib7 6591 7 ( ( -LRB- cord-005453-4057qib7 6591 8 LDNs LDNs NNP cord-005453-4057qib7 6591 9 ) ) -RRB- cord-005453-4057qib7 6591 10 are be VBP cord-005453-4057qib7 6591 11 distinguished distinguish VBN cord-005453-4057qib7 6591 12 from from IN cord-005453-4057qib7 6591 13 normal normal JJ cord-005453-4057qib7 6591 14 - - HYPH cord-005453-4057qib7 6591 15 density density NN cord-005453-4057qib7 6591 16 neutrophils neutrophil NNS cord-005453-4057qib7 6591 17 ( ( -LRB- cord-005453-4057qib7 6591 18 NDNs ndn NNS cord-005453-4057qib7 6591 19 ) ) -RRB- cord-005453-4057qib7 6591 20 by by IN cord-005453-4057qib7 6591 21 their -PRON- PRP$ cord-005453-4057qib7 6591 22 anomalous anomalous JJ cord-005453-4057qib7 6591 23 sedimentation sedimentation NN cord-005453-4057qib7 6591 24 within within IN cord-005453-4057qib7 6591 25 the the DT cord-005453-4057qib7 6591 26 mononuclear mononuclear JJ cord-005453-4057qib7 6591 27 cell cell NN cord-005453-4057qib7 6591 28 fraction fraction NN cord-005453-4057qib7 6591 29 after after IN cord-005453-4057qib7 6591 30 density density NN cord-005453-4057qib7 6591 31 gradient gradient NN cord-005453-4057qib7 6591 32 centrifugation centrifugation NN cord-005453-4057qib7 6591 33 of of IN cord-005453-4057qib7 6591 34 peripheral peripheral JJ cord-005453-4057qib7 6591 35 blood blood NN cord-005453-4057qib7 6591 36 ( ( -LRB- cord-005453-4057qib7 6591 37 PB PB NNP cord-005453-4057qib7 6591 38 ) ) -RRB- cord-005453-4057qib7 6591 39 . . . cord-005453-4057qib7 6592 1 By by IN cord-005453-4057qib7 6592 2 analysing analyse VBG cord-005453-4057qib7 6592 3 LDNs ldn NNS cord-005453-4057qib7 6592 4 and and CC cord-005453-4057qib7 6592 5 NDNs ndn NNS cord-005453-4057qib7 6592 6 from from IN cord-005453-4057qib7 6592 7 G g NN cord-005453-4057qib7 6592 8 - - HYPH cord-005453-4057qib7 6592 9 CSFstimulated csfstimulate VBN cord-005453-4057qib7 6592 10 donors donor NNS cord-005453-4057qib7 6592 11 or or CC cord-005453-4057qib7 6592 12 lymphoma lymphoma NN cord-005453-4057qib7 6592 13 patients patient NNS cord-005453-4057qib7 6592 14 , , , cord-005453-4057qib7 6592 15 we -PRON- PRP cord-005453-4057qib7 6592 16 have have VBP cord-005453-4057qib7 6592 17 previously previously RB cord-005453-4057qib7 6592 18 demonstrated demonstrate VBN cord-005453-4057qib7 6592 19 that that IN cord-005453-4057qib7 6592 20 , , , cord-005453-4057qib7 6592 21 depending depend VBG cord-005453-4057qib7 6592 22 on on IN cord-005453-4057qib7 6592 23 physiopathological physiopathological JJ cord-005453-4057qib7 6592 24 conditions condition NNS cord-005453-4057qib7 6592 25 , , , cord-005453-4057qib7 6592 26 immature immature JJ cord-005453-4057qib7 6592 27 CD66b CD66b NNS cord-005453-4057qib7 6592 28 + + CC cord-005453-4057qib7 6592 29 CD10 CD10 NNP cord-005453-4057qib7 6592 30 -LDNs -ldns TO cord-005453-4057qib7 6592 31 can can MD cord-005453-4057qib7 6592 32 promote promote VB cord-005453-4057qib7 6592 33 T T NNP cord-005453-4057qib7 6592 34 cell cell NN cord-005453-4057qib7 6592 35 survival survival NN cord-005453-4057qib7 6592 36 and and CC cord-005453-4057qib7 6592 37 IFN IFN NNP cord-005453-4057qib7 6592 38 - - HYPH cord-005453-4057qib7 6592 39 γ γ NN cord-005453-4057qib7 6592 40 production production NN cord-005453-4057qib7 6592 41 , , , cord-005453-4057qib7 6592 42 while while IN cord-005453-4057qib7 6592 43 mature mature JJ cord-005453-4057qib7 6592 44 CD66b CD66b NNP cord-005453-4057qib7 6592 45 + + CC cord-005453-4057qib7 6592 46 CD10 CD10 NNP cord-005453-4057qib7 6592 47 + + CC cord-005453-4057qib7 6592 48 LDNs ldn NNS cord-005453-4057qib7 6592 49 can can MD cord-005453-4057qib7 6592 50 exert exert VB cord-005453-4057qib7 6592 51 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6592 52 proprieties propriety NNS cord-005453-4057qib7 6592 53 . . . cord-005453-4057qib7 6593 1 Aim aim VB cord-005453-4057qib7 6593 2 of of IN cord-005453-4057qib7 6593 3 this this DT cord-005453-4057qib7 6593 4 study study NN cord-005453-4057qib7 6593 5 was be VBD cord-005453-4057qib7 6593 6 to to TO cord-005453-4057qib7 6593 7 establish establish VB cord-005453-4057qib7 6593 8 the the DT cord-005453-4057qib7 6593 9 frequency frequency NN cord-005453-4057qib7 6593 10 of of IN cord-005453-4057qib7 6593 11 CD66b cd66b NN cord-005453-4057qib7 6593 12 + + CC cord-005453-4057qib7 6593 13 CD10and cd10and NN cord-005453-4057qib7 6593 14 / / , cord-005453-4057qib7 6593 15 or or CC cord-005453-4057qib7 6593 16 CD66b cd66b NN cord-005453-4057qib7 6593 17 + + CC cord-005453-4057qib7 6593 18 CD10 CD10 NNP cord-005453-4057qib7 6593 19 + + CC cord-005453-4057qib7 6593 20 LDNs ldn NNS cord-005453-4057qib7 6593 21 in in IN cord-005453-4057qib7 6593 22 PB PB NNP cord-005453-4057qib7 6593 23 of of IN cord-005453-4057qib7 6593 24 allogeneic allogeneic JJ cord-005453-4057qib7 6593 25 hematopoietic hematopoietic JJ cord-005453-4057qib7 6593 26 stem stem NN cord-005453-4057qib7 6593 27 cell cell NN cord-005453-4057qib7 6593 28 transplant transplant NN cord-005453-4057qib7 6593 29 ( ( -LRB- cord-005453-4057qib7 6593 30 HSCT HSCT NNP cord-005453-4057qib7 6593 31 ) ) -RRB- cord-005453-4057qib7 6593 32 patients patient NNS cord-005453-4057qib7 6593 33 throughout throughout IN cord-005453-4057qib7 6593 34 immune immune JJ cord-005453-4057qib7 6593 35 reconstitution reconstitution NN cord-005453-4057qib7 6593 36 , , , cord-005453-4057qib7 6593 37 and and CC cord-005453-4057qib7 6593 38 verify verify VB cord-005453-4057qib7 6593 39 their -PRON- PRP$ cord-005453-4057qib7 6593 40 potential potential JJ cord-005453-4057qib7 6593 41 correlation correlation NN cord-005453-4057qib7 6593 42 with with IN cord-005453-4057qib7 6593 43 acute acute JJ cord-005453-4057qib7 6593 44 graft graft NN cord-005453-4057qib7 6593 45 versus versus IN cord-005453-4057qib7 6593 46 host host NN cord-005453-4057qib7 6593 47 disease disease NN cord-005453-4057qib7 6593 48 ( ( -LRB- cord-005453-4057qib7 6593 49 aGVHD aGVHD NNP cord-005453-4057qib7 6593 50 ) ) -RRB- cord-005453-4057qib7 6593 51 . . . cord-005453-4057qib7 6594 1 Methods method NNS cord-005453-4057qib7 6594 2 : : : cord-005453-4057qib7 6594 3 Patients patient NNS cord-005453-4057qib7 6594 4 undergoing undergo VBG cord-005453-4057qib7 6594 5 HSCT HSCT NNP cord-005453-4057qib7 6594 6 in in IN cord-005453-4057qib7 6594 7 our -PRON- PRP$ cord-005453-4057qib7 6594 8 Institution Institution NNP cord-005453-4057qib7 6594 9 between between IN cord-005453-4057qib7 6594 10 December December NNP cord-005453-4057qib7 6594 11 2015 2015 CD cord-005453-4057qib7 6594 12 and and CC cord-005453-4057qib7 6594 13 June June NNP cord-005453-4057qib7 6594 14 2018 2018 CD cord-005453-4057qib7 6594 15 were be VBD cord-005453-4057qib7 6594 16 prospectively prospectively RB cord-005453-4057qib7 6594 17 enrolled enrol VBN cord-005453-4057qib7 6594 18 in in IN cord-005453-4057qib7 6594 19 the the DT cord-005453-4057qib7 6594 20 study study NN cord-005453-4057qib7 6594 21 upon upon IN cord-005453-4057qib7 6594 22 informed informed JJ cord-005453-4057qib7 6594 23 consent consent NN cord-005453-4057qib7 6594 24 and and CC cord-005453-4057qib7 6594 25 after after IN cord-005453-4057qib7 6594 26 Institutional Institutional NNP cord-005453-4057qib7 6594 27 Board Board NNP cord-005453-4057qib7 6594 28 approval approval NN cord-005453-4057qib7 6594 29 . . . cord-005453-4057qib7 6595 1 Criteria criterion NNS cord-005453-4057qib7 6595 2 of of IN cord-005453-4057qib7 6595 3 inclusion inclusion NN cord-005453-4057qib7 6595 4 were be VBD cord-005453-4057qib7 6595 5 age age NN cord-005453-4057qib7 6595 6 ≥ ≥ CD cord-005453-4057qib7 6595 7 18 18 CD cord-005453-4057qib7 6595 8 years year NNS cord-005453-4057qib7 6595 9 and and CC cord-005453-4057qib7 6595 10 absence absence NN cord-005453-4057qib7 6595 11 of of IN cord-005453-4057qib7 6595 12 rheumatologic rheumatologic JJ cord-005453-4057qib7 6595 13 or or CC cord-005453-4057qib7 6595 14 viral viral JJ cord-005453-4057qib7 6595 15 diseases disease NNS cord-005453-4057qib7 6595 16 . . . cord-005453-4057qib7 6596 1 PB PB NNP cord-005453-4057qib7 6596 2 samples sample NNS cord-005453-4057qib7 6596 3 were be VBD cord-005453-4057qib7 6596 4 collected collect VBN cord-005453-4057qib7 6596 5 at at IN cord-005453-4057qib7 6596 6 day day NN cord-005453-4057qib7 6596 7 +21 +21 NNS cord-005453-4057qib7 6596 8 , , , cord-005453-4057qib7 6596 9 +42 +42 NN cord-005453-4057qib7 6596 10 , , , cord-005453-4057qib7 6596 11 +60 +60 NNP cord-005453-4057qib7 6596 12 , , , cord-005453-4057qib7 6596 13 +90 +90 NN cord-005453-4057qib7 6596 14 and and CC cord-005453-4057qib7 6596 15 +180 +180 NNP cord-005453-4057qib7 6596 16 after after IN cord-005453-4057qib7 6596 17 HSCT HSCT NNP cord-005453-4057qib7 6596 18 and and CC cord-005453-4057qib7 6596 19 any any DT cord-005453-4057qib7 6596 20 time time NN cord-005453-4057qib7 6596 21 within within IN cord-005453-4057qib7 6596 22 day day NN cord-005453-4057qib7 6596 23 +180 +180 NNP cord-005453-4057qib7 6596 24 in in IN cord-005453-4057qib7 6596 25 case case NN cord-005453-4057qib7 6596 26 of of IN cord-005453-4057qib7 6596 27 GVHD GVHD NNP cord-005453-4057qib7 6596 28 , , , cord-005453-4057qib7 6596 29 before before IN cord-005453-4057qib7 6596 30 first first JJ cord-005453-4057qib7 6596 31 - - HYPH cord-005453-4057qib7 6596 32 line line NN cord-005453-4057qib7 6596 33 therapy therapy NN cord-005453-4057qib7 6596 34 . . . cord-005453-4057qib7 6597 1 Eight eight CD cord-005453-4057qib7 6597 2 healthy healthy JJ cord-005453-4057qib7 6597 3 donors donor NNS cord-005453-4057qib7 6597 4 ( ( -LRB- cord-005453-4057qib7 6597 5 HDs hd NNS cord-005453-4057qib7 6597 6 ) ) -RRB- cord-005453-4057qib7 6597 7 were be VBD cord-005453-4057qib7 6597 8 enrolled enrol VBN cord-005453-4057qib7 6597 9 as as IN cord-005453-4057qib7 6597 10 control control NN cord-005453-4057qib7 6597 11 . . . cord-005453-4057qib7 6598 1 Mononuclear Mononuclear NNP cord-005453-4057qib7 6598 2 , , , cord-005453-4057qib7 6598 3 polymorphonuclear polymorphonuclear NN cord-005453-4057qib7 6598 4 , , , cord-005453-4057qib7 6598 5 and and CC cord-005453-4057qib7 6598 6 whole whole JJ cord-005453-4057qib7 6598 7 blood blood NN cord-005453-4057qib7 6598 8 cells cell NNS cord-005453-4057qib7 6598 9 were be VBD cord-005453-4057qib7 6598 10 analysed analyse VBN cord-005453-4057qib7 6598 11 by by IN cord-005453-4057qib7 6598 12 flow flow NN cord-005453-4057qib7 6598 13 cytometry cytometry NN cord-005453-4057qib7 6598 14 after after IN cord-005453-4057qib7 6598 15 CD45 CD45 NNP cord-005453-4057qib7 6598 16 Vioblue Vioblue NNP cord-005453-4057qib7 6598 17 , , , cord-005453-4057qib7 6598 18 CD16 CD16 NNP cord-005453-4057qib7 6598 19 APC APC NNP cord-005453-4057qib7 6598 20 - - HYPH cord-005453-4057qib7 6598 21 Cy7 Cy7 NNP cord-005453-4057qib7 6598 22 , , , cord-005453-4057qib7 6598 23 CD11b CD11b VBZ cord-005453-4057qib7 6598 24 PE pe NN cord-005453-4057qib7 6598 25 - - HYPH cord-005453-4057qib7 6598 26 Cy7 Cy7 NNP cord-005453-4057qib7 6598 27 , , , cord-005453-4057qib7 6599 1 CD10 CD10 NNP cord-005453-4057qib7 6599 2 PE PE NNP cord-005453-4057qib7 6599 3 , , , cord-005453-4057qib7 6599 4 CD66b cd66b NN cord-005453-4057qib7 6599 5 FITC FITC NNP cord-005453-4057qib7 6599 6 staining stain VBG cord-005453-4057qib7 6599 7 . . . cord-005453-4057qib7 6600 1 CD66b cd66b NN cord-005453-4057qib7 6600 2 + + CC cord-005453-4057qib7 6600 3 LDNs ldn NNS cord-005453-4057qib7 6600 4 were be VBD cord-005453-4057qib7 6600 5 expressed express VBN cord-005453-4057qib7 6600 6 as as IN cord-005453-4057qib7 6600 7 percentage percentage NN cord-005453-4057qib7 6600 8 of of IN cord-005453-4057qib7 6600 9 CD45 CD45 NNP cord-005453-4057qib7 6600 10 + + SYM cord-005453-4057qib7 6600 11 PB PB NNP cord-005453-4057qib7 6600 12 mononuclear mononuclear NN cord-005453-4057qib7 6600 13 cells cell NNS cord-005453-4057qib7 6600 14 ( ( -LRB- cord-005453-4057qib7 6600 15 PBMCs pbmc NNS cord-005453-4057qib7 6600 16 ) ) -RRB- cord-005453-4057qib7 6600 17 or or CC cord-005453-4057qib7 6600 18 CD45 CD45 NNP cord-005453-4057qib7 6600 19 + + CC cord-005453-4057qib7 6600 20 whole whole JJ cord-005453-4057qib7 6600 21 blood blood NN cord-005453-4057qib7 6600 22 cells cell NNS cord-005453-4057qib7 6600 23 and and CC cord-005453-4057qib7 6600 24 were be VBD cord-005453-4057qib7 6600 25 further further RB cord-005453-4057qib7 6600 26 characterized characterize VBN cord-005453-4057qib7 6600 27 based base VBN cord-005453-4057qib7 6600 28 on on IN cord-005453-4057qib7 6600 29 CD10 CD10 NNP cord-005453-4057qib7 6600 30 expression expression NN cord-005453-4057qib7 6600 31 . . . cord-005453-4057qib7 6601 1 CD66b CD66b NNS cord-005453-4057qib7 6601 2 + + CC cord-005453-4057qib7 6601 3 NDNs ndn NNS cord-005453-4057qib7 6601 4 , , , cord-005453-4057qib7 6601 5 expressed express VBN cord-005453-4057qib7 6601 6 as as IN cord-005453-4057qib7 6601 7 percentage percentage NN cord-005453-4057qib7 6601 8 of of IN cord-005453-4057qib7 6601 9 CD45 CD45 NNP cord-005453-4057qib7 6601 10 + + CC cord-005453-4057qib7 6601 11 whole whole JJ cord-005453-4057qib7 6601 12 blood blood NN cord-005453-4057qib7 6601 13 cells cell NNS cord-005453-4057qib7 6601 14 , , , cord-005453-4057qib7 6601 15 were be VBD cord-005453-4057qib7 6601 16 also also RB cord-005453-4057qib7 6601 17 analysed analyse VBN cord-005453-4057qib7 6601 18 for for IN cord-005453-4057qib7 6601 19 CD10 CD10 NNP cord-005453-4057qib7 6601 20 staining staining NN cord-005453-4057qib7 6601 21 . . . cord-005453-4057qib7 6602 1 Results result NNS cord-005453-4057qib7 6602 2 : : : cord-005453-4057qib7 6602 3 39 39 CD cord-005453-4057qib7 6602 4 patients patient NNS cord-005453-4057qib7 6602 5 ( ( -LRB- cord-005453-4057qib7 6602 6 M M NNP cord-005453-4057qib7 6602 7 / / SYM cord-005453-4057qib7 6602 8 F F NNP cord-005453-4057qib7 6602 9 25/14 25/14 CD cord-005453-4057qib7 6602 10 , , , cord-005453-4057qib7 6602 11 median median JJ cord-005453-4057qib7 6602 12 age age NN cord-005453-4057qib7 6602 13 47 47 CD cord-005453-4057qib7 6602 14 ) ) -RRB- cord-005453-4057qib7 6602 15 were be VBD cord-005453-4057qib7 6602 16 enrolled enrol VBN cord-005453-4057qib7 6602 17 in in IN cord-005453-4057qib7 6602 18 the the DT cord-005453-4057qib7 6602 19 study study NN cord-005453-4057qib7 6602 20 . . . cord-005453-4057qib7 6603 1 Patients patient NNS cord-005453-4057qib7 6603 2 received receive VBD cord-005453-4057qib7 6603 3 HSCT HSCT NNP cord-005453-4057qib7 6603 4 from from IN cord-005453-4057qib7 6603 5 HLAidentical HLAidentical NNP cord-005453-4057qib7 6603 6 ( ( -LRB- cord-005453-4057qib7 6603 7 13 13 CD cord-005453-4057qib7 6603 8 ) ) -RRB- cord-005453-4057qib7 6603 9 or or CC cord-005453-4057qib7 6603 10 haploidentical haploidentical JJ cord-005453-4057qib7 6603 11 ( ( -LRB- cord-005453-4057qib7 6603 12 6 6 CD cord-005453-4057qib7 6603 13 ) ) -RRB- cord-005453-4057qib7 6603 14 related relate VBN cord-005453-4057qib7 6603 15 and and CC cord-005453-4057qib7 6603 16 from from IN cord-005453-4057qib7 6603 17 HLAidentical hlaidentical JJ cord-005453-4057qib7 6603 18 unrelated unrelated JJ cord-005453-4057qib7 6603 19 ( ( -LRB- cord-005453-4057qib7 6603 20 20 20 CD cord-005453-4057qib7 6603 21 ) ) -RRB- cord-005453-4057qib7 6603 22 donors donor NNS cord-005453-4057qib7 6603 23 . . . cord-005453-4057qib7 6604 1 After after IN cord-005453-4057qib7 6604 2 a a DT cord-005453-4057qib7 6604 3 median median JJ cord-005453-4057qib7 6604 4 time time NN cord-005453-4057qib7 6604 5 of of IN cord-005453-4057qib7 6604 6 33 33 CD cord-005453-4057qib7 6604 7 ( ( -LRB- cord-005453-4057qib7 6604 8 15 15 CD cord-005453-4057qib7 6604 9 - - SYM cord-005453-4057qib7 6604 10 95 95 CD cord-005453-4057qib7 6604 11 ) ) -RRB- cord-005453-4057qib7 6604 12 days day NNS cord-005453-4057qib7 6604 13 , , , cord-005453-4057qib7 6604 14 13 13 CD cord-005453-4057qib7 6604 15 patients patient NNS cord-005453-4057qib7 6604 16 developed develop VBD cord-005453-4057qib7 6604 17 grade grade NN cord-005453-4057qib7 6604 18 II II NNP cord-005453-4057qib7 6604 19 - - HYPH cord-005453-4057qib7 6604 20 IV IV NNP cord-005453-4057qib7 6604 21 aGVHD aGVHD NNP cord-005453-4057qib7 6604 22 . . . cord-005453-4057qib7 6605 1 No no DT cord-005453-4057qib7 6605 2 patients patient NNS cord-005453-4057qib7 6605 3 were be VBD cord-005453-4057qib7 6605 4 receiving receive VBG cord-005453-4057qib7 6605 5 G G NNP cord-005453-4057qib7 6605 6 - - HYPH cord-005453-4057qib7 6605 7 CSF CSF NNP cord-005453-4057qib7 6605 8 at at IN cord-005453-4057qib7 6605 9 aGVHD aGVHD NNP cord-005453-4057qib7 6605 10 onset onset NN cord-005453-4057qib7 6605 11 . . . cord-005453-4057qib7 6606 1 The the DT cord-005453-4057qib7 6606 2 scheduled schedule VBN cord-005453-4057qib7 6606 3 assessments assessment NNS cord-005453-4057qib7 6606 4 were be VBD cord-005453-4057qib7 6606 5 interrupted interrupt VBN cord-005453-4057qib7 6606 6 in in IN cord-005453-4057qib7 6606 7 aGVHD aGVHD NNP cord-005453-4057qib7 6606 8 patients patient NNS cord-005453-4057qib7 6606 9 at at IN cord-005453-4057qib7 6606 10 the the DT cord-005453-4057qib7 6606 11 beginning beginning NN cord-005453-4057qib7 6606 12 of of IN cord-005453-4057qib7 6606 13 first first JJ cord-005453-4057qib7 6606 14 - - HYPH cord-005453-4057qib7 6606 15 line line NN cord-005453-4057qib7 6606 16 treatment treatment NN cord-005453-4057qib7 6606 17 and and CC cord-005453-4057qib7 6606 18 in in IN cord-005453-4057qib7 6606 19 4 4 CD cord-005453-4057qib7 6606 20 patients patient NNS cord-005453-4057qib7 6606 21 relapsed relapse VBN cord-005453-4057qib7 6606 22 of of IN cord-005453-4057qib7 6606 23 their -PRON- PRP$ cord-005453-4057qib7 6606 24 primary primary JJ cord-005453-4057qib7 6606 25 malignancy malignancy NN cord-005453-4057qib7 6606 26 . . . cord-005453-4057qib7 6607 1 No no DT cord-005453-4057qib7 6607 2 patients patient NNS cord-005453-4057qib7 6607 3 developed develop VBD cord-005453-4057qib7 6607 4 de de IN cord-005453-4057qib7 6607 5 novo novo NNP cord-005453-4057qib7 6607 6 late late JJ cord-005453-4057qib7 6607 7 - - HYPH cord-005453-4057qib7 6607 8 acute acute JJ cord-005453-4057qib7 6607 9 or or CC cord-005453-4057qib7 6607 10 chronic chronic JJ cord-005453-4057qib7 6607 11 GVHD GVHD NNP cord-005453-4057qib7 6607 12 . . . cord-005453-4057qib7 6608 1 Starting start VBG cord-005453-4057qib7 6608 2 from from IN cord-005453-4057qib7 6608 3 day day NN cord-005453-4057qib7 6608 4 +21 +21 VBZ cord-005453-4057qib7 6608 5 the the DT cord-005453-4057qib7 6608 6 frequency frequency NN cord-005453-4057qib7 6608 7 of of IN cord-005453-4057qib7 6608 8 LDNs ldns NN cord-005453-4057qib7 6608 9 within within IN cord-005453-4057qib7 6608 10 CD45 CD45 NNP cord-005453-4057qib7 6608 11 + + CC cord-005453-4057qib7 6608 12 PBMCs pbmc NNS cord-005453-4057qib7 6608 13 was be VBD cord-005453-4057qib7 6608 14 higher high JJR cord-005453-4057qib7 6608 15 in in IN cord-005453-4057qib7 6608 16 all all DT cord-005453-4057qib7 6608 17 patients patient NNS cord-005453-4057qib7 6608 18 as as IN cord-005453-4057qib7 6608 19 compared compare VBN cord-005453-4057qib7 6608 20 to to IN cord-005453-4057qib7 6608 21 HDs hd NNS cord-005453-4057qib7 6608 22 . . . cord-005453-4057qib7 6609 1 The the DT cord-005453-4057qib7 6609 2 25 25 CD cord-005453-4057qib7 6609 3 patients patient NNS cord-005453-4057qib7 6609 4 that that WDT cord-005453-4057qib7 6609 5 did do VBD cord-005453-4057qib7 6609 6 not not RB cord-005453-4057qib7 6609 7 develop develop VB cord-005453-4057qib7 6609 8 aGVHD aGVHD NNP cord-005453-4057qib7 6609 9 showed show VBD cord-005453-4057qib7 6609 10 a a DT cord-005453-4057qib7 6609 11 decreasing decrease VBG cord-005453-4057qib7 6609 12 frequency frequency NN cord-005453-4057qib7 6609 13 of of IN cord-005453-4057qib7 6609 14 CD66b cd66b NN cord-005453-4057qib7 6609 15 + + CC cord-005453-4057qib7 6609 16 CD10 CD10 NNP cord-005453-4057qib7 6609 17 -LDNs -ldns CD cord-005453-4057qib7 6609 18 , , , cord-005453-4057qib7 6609 19 with with IN cord-005453-4057qib7 6609 20 a a DT cord-005453-4057qib7 6609 21 progressive progressive JJ cord-005453-4057qib7 6609 22 increase increase NN cord-005453-4057qib7 6609 23 of of IN cord-005453-4057qib7 6609 24 CD66b cd66b NN cord-005453-4057qib7 6609 25 + + CC cord-005453-4057qib7 6609 26 CD10 CD10 NNP cord-005453-4057qib7 6609 27 + + CC cord-005453-4057qib7 6609 28 LDNs ldn NNS cord-005453-4057qib7 6609 29 , , , cord-005453-4057qib7 6609 30 from from IN cord-005453-4057qib7 6609 31 day day NN cord-005453-4057qib7 6609 32 +21 +21 CD cord-005453-4057qib7 6610 1 to to IN cord-005453-4057qib7 6610 2 +180 +180 NNP cord-005453-4057qib7 6610 3 . . . cord-005453-4057qib7 6611 1 Interestingly interestingly RB cord-005453-4057qib7 6611 2 , , , cord-005453-4057qib7 6611 3 patients patient NNS cord-005453-4057qib7 6611 4 with with IN cord-005453-4057qib7 6611 5 aGVHD aGVHD NNP cord-005453-4057qib7 6611 6 showed show VBD cord-005453-4057qib7 6611 7 a a DT cord-005453-4057qib7 6611 8 significantly significantly RB cord-005453-4057qib7 6611 9 higher high JJR cord-005453-4057qib7 6611 10 frequency frequency NN cord-005453-4057qib7 6611 11 of of IN cord-005453-4057qib7 6611 12 CD66b cd66b NN cord-005453-4057qib7 6612 1 + + CC cord-005453-4057qib7 6612 2 CD10 CD10 NNP cord-005453-4057qib7 6612 3 -LDNs -ldns CD cord-005453-4057qib7 6612 4 as as IN cord-005453-4057qib7 6612 5 compared compare VBN cord-005453-4057qib7 6612 6 to to IN cord-005453-4057qib7 6612 7 patients patient NNS cord-005453-4057qib7 6612 8 without without IN cord-005453-4057qib7 6612 9 aGVHD aGVHD NNP cord-005453-4057qib7 6612 10 throughout throughout IN cord-005453-4057qib7 6612 11 the the DT cord-005453-4057qib7 6612 12 same same JJ cord-005453-4057qib7 6612 13 time time NN cord-005453-4057qib7 6612 14 lapse lapse NN cord-005453-4057qib7 6612 15 ( ( -LRB- cord-005453-4057qib7 6612 16 i.e. i.e. FW cord-005453-4057qib7 6612 17 from from IN cord-005453-4057qib7 6612 18 day day NN cord-005453-4057qib7 6612 19 +21 +21 CD cord-005453-4057qib7 6612 20 to to IN cord-005453-4057qib7 6612 21 +90 +90 CD cord-005453-4057qib7 6612 22 ) ) -RRB- cord-005453-4057qib7 6612 23 ( ( -LRB- cord-005453-4057qib7 6612 24 83.15 83.15 CD cord-005453-4057qib7 6612 25 vs vs IN cord-005453-4057qib7 6612 26 50.8 50.8 CD cord-005453-4057qib7 6612 27 , , , cord-005453-4057qib7 6612 28 p=0.027 p=0.027 NNP cord-005453-4057qib7 6612 29 ) ) -RRB- cord-005453-4057qib7 6612 30 . . . cord-005453-4057qib7 6613 1 Consistently consistently RB cord-005453-4057qib7 6613 2 , , , cord-005453-4057qib7 6613 3 patients patient NNS cord-005453-4057qib7 6613 4 with with IN cord-005453-4057qib7 6613 5 aGVHD aGVHD NNP cord-005453-4057qib7 6613 6 had have VBD cord-005453-4057qib7 6613 7 a a DT cord-005453-4057qib7 6613 8 significantly significantly RB cord-005453-4057qib7 6613 9 lower low JJR cord-005453-4057qib7 6613 10 frequency frequency NN cord-005453-4057qib7 6613 11 of of IN cord-005453-4057qib7 6613 12 CD66b cd66b NN cord-005453-4057qib7 6613 13 + + CC cord-005453-4057qib7 6613 14 CD10 CD10 NNP cord-005453-4057qib7 6613 15 + + CC cord-005453-4057qib7 6613 16 LDNs LDNs NNP cord-005453-4057qib7 6613 17 ( ( -LRB- cord-005453-4057qib7 6613 18 12.1 12.1 CD cord-005453-4057qib7 6613 19 vs vs IN cord-005453-4057qib7 6613 20 50.05 50.05 CD cord-005453-4057qib7 6613 21 , , , cord-005453-4057qib7 6613 22 p=0.0014 p=0.0014 NNPS cord-005453-4057qib7 6613 23 ) ) -RRB- cord-005453-4057qib7 6613 24 . . . cord-005453-4057qib7 6614 1 The the DT cord-005453-4057qib7 6614 2 frequency frequency NN cord-005453-4057qib7 6614 3 of of IN cord-005453-4057qib7 6614 4 mature mature JJ cord-005453-4057qib7 6614 5 CD66b CD66b NNP cord-005453-4057qib7 6614 6 + + CC cord-005453-4057qib7 6614 7 CD10 CD10 NNP cord-005453-4057qib7 6614 8 + + CC cord-005453-4057qib7 6614 9 NDNs ndn NNS cord-005453-4057qib7 6614 10 was be VBD cord-005453-4057qib7 6614 11 normal normal JJ cord-005453-4057qib7 6614 12 in in IN cord-005453-4057qib7 6614 13 all all DT cord-005453-4057qib7 6614 14 patients patient NNS cord-005453-4057qib7 6614 15 since since IN cord-005453-4057qib7 6614 16 day day NN cord-005453-4057qib7 6614 17 +21 +21 CD cord-005453-4057qib7 6614 18 . . . cord-005453-4057qib7 6615 1 Conclusions conclusion NNS cord-005453-4057qib7 6615 2 : : : cord-005453-4057qib7 6616 1 LDNs LDNs NNP cord-005453-4057qib7 6616 2 are be VBP cord-005453-4057qib7 6616 3 more more RBR cord-005453-4057qib7 6616 4 represented represent VBN cord-005453-4057qib7 6616 5 in in IN cord-005453-4057qib7 6616 6 HSCT HSCT NNP cord-005453-4057qib7 6616 7 patients patient NNS cord-005453-4057qib7 6616 8 than than IN cord-005453-4057qib7 6616 9 in in IN cord-005453-4057qib7 6616 10 HDs HDs NNP cord-005453-4057qib7 6616 11 , , , cord-005453-4057qib7 6616 12 with with IN cord-005453-4057qib7 6616 13 a a DT cord-005453-4057qib7 6616 14 significant significant JJ cord-005453-4057qib7 6616 15 expansion expansion NN cord-005453-4057qib7 6616 16 of of IN cord-005453-4057qib7 6616 17 the the DT cord-005453-4057qib7 6616 18 CD66b CD66b NNS cord-005453-4057qib7 6616 19 + + CC cord-005453-4057qib7 6616 20 CD10subpopulation cd10subpopulation NN cord-005453-4057qib7 6617 1 ( ( -LRB- cord-005453-4057qib7 6617 2 with with IN cord-005453-4057qib7 6617 3 a a DT cord-005453-4057qib7 6617 4 parallel parallel JJ cord-005453-4057qib7 6617 5 decrease decrease NN cord-005453-4057qib7 6617 6 of of IN cord-005453-4057qib7 6617 7 the the DT cord-005453-4057qib7 6617 8 CD66b CD66b NNS cord-005453-4057qib7 6617 9 + + CC cord-005453-4057qib7 6617 10 CD10 CD10 NNP cord-005453-4057qib7 6617 11 + + CC cord-005453-4057qib7 6617 12 subpopulation subpopulation NN cord-005453-4057qib7 6617 13 ) ) -RRB- cord-005453-4057qib7 6617 14 in in IN cord-005453-4057qib7 6617 15 patients patient NNS cord-005453-4057qib7 6617 16 with with IN cord-005453-4057qib7 6617 17 aGVHD aGVHD NNP cord-005453-4057qib7 6617 18 as as IN cord-005453-4057qib7 6617 19 compared compare VBN cord-005453-4057qib7 6617 20 to to IN cord-005453-4057qib7 6617 21 those those DT cord-005453-4057qib7 6617 22 without without IN cord-005453-4057qib7 6617 23 aGVHD aGVHD NNP cord-005453-4057qib7 6617 24 . . . cord-005453-4057qib7 6618 1 According accord VBG cord-005453-4057qib7 6618 2 to to IN cord-005453-4057qib7 6618 3 the the DT cord-005453-4057qib7 6618 4 previously previously RB cord-005453-4057qib7 6618 5 demonstrated demonstrate VBN cord-005453-4057qib7 6618 6 T t NN cord-005453-4057qib7 6618 7 cell cell NN cord-005453-4057qib7 6618 8 activating activate VBG cord-005453-4057qib7 6618 9 function function NN cord-005453-4057qib7 6618 10 of of IN cord-005453-4057qib7 6618 11 CD66b CD66b NNS cord-005453-4057qib7 6618 12 + + CC cord-005453-4057qib7 6618 13 CD10 CD10 NNP cord-005453-4057qib7 6618 14 -LDNs -ldns XX cord-005453-4057qib7 6618 15 , , , cord-005453-4057qib7 6618 16 it -PRON- PRP cord-005453-4057qib7 6618 17 is be VBZ cord-005453-4057qib7 6618 18 tempting tempt VBG cord-005453-4057qib7 6618 19 to to TO cord-005453-4057qib7 6618 20 speculate speculate VB cord-005453-4057qib7 6618 21 that that IN cord-005453-4057qib7 6618 22 the the DT cord-005453-4057qib7 6618 23 expansion expansion NN cord-005453-4057qib7 6618 24 of of IN cord-005453-4057qib7 6618 25 this this DT cord-005453-4057qib7 6618 26 subpopulation subpopulation NN cord-005453-4057qib7 6618 27 may may MD cord-005453-4057qib7 6618 28 contribute contribute VB cord-005453-4057qib7 6618 29 to to IN cord-005453-4057qib7 6618 30 aGVHD aGVHD NNP cord-005453-4057qib7 6618 31 development development NN cord-005453-4057qib7 6618 32 . . . cord-005453-4057qib7 6619 1 Disclosure disclosure NN cord-005453-4057qib7 6619 2 : : : cord-005453-4057qib7 6619 3 Nothing nothing NN cord-005453-4057qib7 6619 4 to to TO cord-005453-4057qib7 6619 5 declare declare VB cord-005453-4057qib7 6619 6 Background background NN cord-005453-4057qib7 6619 7 : : : cord-005453-4057qib7 6620 1 Acute acute JJ cord-005453-4057qib7 6620 2 graft graft NN cord-005453-4057qib7 6620 3 - - HYPH cord-005453-4057qib7 6620 4 versus versus IN cord-005453-4057qib7 6620 5 - - HYPH cord-005453-4057qib7 6620 6 host host NN cord-005453-4057qib7 6620 7 disease disease NN cord-005453-4057qib7 6620 8 ( ( -LRB- cord-005453-4057qib7 6620 9 aGVHD aGVHD NNP cord-005453-4057qib7 6620 10 ) ) -RRB- cord-005453-4057qib7 6620 11 is be VBZ cord-005453-4057qib7 6620 12 a a DT cord-005453-4057qib7 6620 13 major major JJ cord-005453-4057qib7 6620 14 complication complication NN cord-005453-4057qib7 6620 15 after after IN cord-005453-4057qib7 6620 16 allogeneic allogeneic JJ cord-005453-4057qib7 6620 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 6620 18 stem stem NN cord-005453-4057qib7 6620 19 cell cell NN cord-005453-4057qib7 6620 20 transplantation transplantation NN cord-005453-4057qib7 6620 21 ( ( -LRB- cord-005453-4057qib7 6620 22 allo allo NN cord-005453-4057qib7 6620 23 - - HYPH cord-005453-4057qib7 6620 24 HSCT HSCT NNP cord-005453-4057qib7 6620 25 ) ) -RRB- cord-005453-4057qib7 6620 26 which which WDT cord-005453-4057qib7 6620 27 has have VBZ cord-005453-4057qib7 6620 28 negative negative JJ cord-005453-4057qib7 6620 29 impact impact NN cord-005453-4057qib7 6620 30 on on IN cord-005453-4057qib7 6620 31 the the DT cord-005453-4057qib7 6620 32 morbidity morbidity NN cord-005453-4057qib7 6620 33 and and CC cord-005453-4057qib7 6620 34 mortality mortality NN cord-005453-4057qib7 6620 35 of of IN cord-005453-4057qib7 6620 36 the the DT cord-005453-4057qib7 6620 37 patients patient NNS cord-005453-4057qib7 6620 38 . . . cord-005453-4057qib7 6621 1 Accumulating accumulate VBG cord-005453-4057qib7 6621 2 evidences evidence NNS cord-005453-4057qib7 6621 3 suggest suggest VBP cord-005453-4057qib7 6621 4 that that IN cord-005453-4057qib7 6621 5 abnormalities abnormality NNS cord-005453-4057qib7 6621 6 of of IN cord-005453-4057qib7 6621 7 Foxp3 foxp3 JJ cord-005453-4057qib7 6621 8 + + CC cord-005453-4057qib7 6621 9 Regulatory Regulatory NNP cord-005453-4057qib7 6621 10 T T NNP cord-005453-4057qib7 6621 11 ( ( -LRB- cord-005453-4057qib7 6621 12 Treg Treg NNP cord-005453-4057qib7 6621 13 ) ) -RRB- cord-005453-4057qib7 6621 14 cells cell NNS cord-005453-4057qib7 6621 15 contributed contribute VBD cord-005453-4057qib7 6621 16 to to IN cord-005453-4057qib7 6621 17 the the DT cord-005453-4057qib7 6621 18 pathogenesis pathogenesis NN cord-005453-4057qib7 6621 19 of of IN cord-005453-4057qib7 6621 20 GVHD GVHD NNP cord-005453-4057qib7 6621 21 , , , cord-005453-4057qib7 6621 22 but but CC cord-005453-4057qib7 6621 23 the the DT cord-005453-4057qib7 6621 24 underlying underlying JJ cord-005453-4057qib7 6621 25 molecular molecular JJ cord-005453-4057qib7 6621 26 mechanisms mechanism NNS cord-005453-4057qib7 6621 27 still still RB cord-005453-4057qib7 6621 28 remain remain VBP cord-005453-4057qib7 6621 29 largely largely RB cord-005453-4057qib7 6621 30 unknown unknown JJ cord-005453-4057qib7 6621 31 . . . cord-005453-4057qib7 6622 1 Methods method NNS cord-005453-4057qib7 6622 2 : : : cord-005453-4057qib7 6622 3 In in IN cord-005453-4057qib7 6622 4 this this DT cord-005453-4057qib7 6622 5 study study NN cord-005453-4057qib7 6622 6 , , , cord-005453-4057qib7 6622 7 we -PRON- PRP cord-005453-4057qib7 6622 8 enrolled enrol VBD cord-005453-4057qib7 6622 9 all all PDT cord-005453-4057qib7 6622 10 the the DT cord-005453-4057qib7 6622 11 40 40 CD cord-005453-4057qib7 6622 12 patients patient NNS cord-005453-4057qib7 6622 13 treated treat VBN cord-005453-4057qib7 6622 14 with with IN cord-005453-4057qib7 6622 15 allogeneic allogeneic IN cord-005453-4057qib7 6622 16 HSCT HSCT NNP cord-005453-4057qib7 6622 17 at at IN cord-005453-4057qib7 6622 18 the the DT cord-005453-4057qib7 6622 19 Institute Institute NNP cord-005453-4057qib7 6622 20 of of IN cord-005453-4057qib7 6622 21 Hematology Hematology NNP cord-005453-4057qib7 6622 22 , , , cord-005453-4057qib7 6622 23 Chinese Chinese NNP cord-005453-4057qib7 6622 24 Academy Academy NNP cord-005453-4057qib7 6622 25 of of IN cord-005453-4057qib7 6622 26 Medical Medical NNP cord-005453-4057qib7 6622 27 Sciences Sciences NNPS cord-005453-4057qib7 6622 28 between between IN cord-005453-4057qib7 6622 29 2016 2016 CD cord-005453-4057qib7 6622 30 and and CC cord-005453-4057qib7 6622 31 2018,as 2018,as CD cord-005453-4057qib7 6622 32 well well RB cord-005453-4057qib7 6622 33 as as IN cord-005453-4057qib7 6622 34 10 10 CD cord-005453-4057qib7 6622 35 age age NN cord-005453-4057qib7 6622 36 - - HYPH cord-005453-4057qib7 6622 37 matched match VBN cord-005453-4057qib7 6622 38 healthy healthy JJ cord-005453-4057qib7 6622 39 adults adult NNS cord-005453-4057qib7 6622 40 as as IN cord-005453-4057qib7 6622 41 control control NN cord-005453-4057qib7 6622 42 samples sample NNS cord-005453-4057qib7 6622 43 . . . cord-005453-4057qib7 6623 1 The the DT cord-005453-4057qib7 6623 2 ratio ratio NN cord-005453-4057qib7 6623 3 of of IN cord-005453-4057qib7 6623 4 Tregs Tregs NNP cord-005453-4057qib7 6623 5 in in IN cord-005453-4057qib7 6623 6 PB PB NNP cord-005453-4057qib7 6623 7 and and CC cord-005453-4057qib7 6623 8 BM BM NNP cord-005453-4057qib7 6623 9 of of IN cord-005453-4057qib7 6623 10 healthy healthy JJ cord-005453-4057qib7 6623 11 controls control NNS cord-005453-4057qib7 6623 12 ( ( -LRB- cord-005453-4057qib7 6623 13 HCs HCs NNP cord-005453-4057qib7 6623 14 ) ) -RRB- cord-005453-4057qib7 6623 15 and and CC cord-005453-4057qib7 6623 16 patients patient NNS cord-005453-4057qib7 6623 17 with with IN cord-005453-4057qib7 6623 18 and and CC cord-005453-4057qib7 6623 19 without without IN cord-005453-4057qib7 6623 20 aGVHD aGVHD NNP cord-005453-4057qib7 6623 21 was be VBD cord-005453-4057qib7 6623 22 determined determine VBN cord-005453-4057qib7 6623 23 by by IN cord-005453-4057qib7 6623 24 flow flow NN cord-005453-4057qib7 6623 25 cytometry cytometry NN cord-005453-4057qib7 6623 26 . . . cord-005453-4057qib7 6624 1 The the DT cord-005453-4057qib7 6624 2 transcription transcription NN cord-005453-4057qib7 6624 3 profile profile NN cord-005453-4057qib7 6624 4 between between IN cord-005453-4057qib7 6624 5 Tregs Tregs NNP cord-005453-4057qib7 6624 6 from from IN cord-005453-4057qib7 6624 7 patients patient NNS cord-005453-4057qib7 6624 8 with with IN cord-005453-4057qib7 6624 9 or or CC cord-005453-4057qib7 6624 10 without without IN cord-005453-4057qib7 6624 11 acute acute JJ cord-005453-4057qib7 6624 12 GVHD GVHD NNP cord-005453-4057qib7 6624 13 was be VBD cord-005453-4057qib7 6624 14 measured measure VBN cord-005453-4057qib7 6624 15 , , , cord-005453-4057qib7 6624 16 the the DT cord-005453-4057qib7 6624 17 pathway pathway NN cord-005453-4057qib7 6624 18 enrichment enrichment NN cord-005453-4057qib7 6624 19 analyses analysis NNS cord-005453-4057qib7 6624 20 were be VBD cord-005453-4057qib7 6624 21 performed perform VBN cord-005453-4057qib7 6624 22 by by IN cord-005453-4057qib7 6624 23 the the DT cord-005453-4057qib7 6624 24 Kyoto Kyoto NNP cord-005453-4057qib7 6624 25 Encyclopedia Encyclopedia NNP cord-005453-4057qib7 6624 26 of of IN cord-005453-4057qib7 6624 27 Genes Genes NNPS cord-005453-4057qib7 6624 28 and and CC cord-005453-4057qib7 6624 29 Genomes Genomes NNPS cord-005453-4057qib7 6624 30 ( ( -LRB- cord-005453-4057qib7 6624 31 KEGG KEGG NNP cord-005453-4057qib7 6624 32 ) ) -RRB- cord-005453-4057qib7 6624 33 pathway pathway NN cord-005453-4057qib7 6624 34 database database NN cord-005453-4057qib7 6624 35 and and CC cord-005453-4057qib7 6624 36 geneset geneset NNP cord-005453-4057qib7 6624 37 enrichment enrichment NNP cord-005453-4057qib7 6624 38 analysis analysis NNP cord-005453-4057qib7 6625 1 ( ( -LRB- cord-005453-4057qib7 6625 2 GSEA).The gsea).the JJ cord-005453-4057qib7 6625 3 expression expression NN cord-005453-4057qib7 6625 4 of of IN cord-005453-4057qib7 6625 5 Lkb1 Lkb1 NNP cord-005453-4057qib7 6625 6 at at IN cord-005453-4057qib7 6625 7 transcript transcript NN cord-005453-4057qib7 6625 8 levels level NNS cord-005453-4057qib7 6625 9 and and CC cord-005453-4057qib7 6625 10 protein protein NN cord-005453-4057qib7 6625 11 levels level NNS cord-005453-4057qib7 6625 12 was be VBD cord-005453-4057qib7 6625 13 measured measure VBN cord-005453-4057qib7 6625 14 by by IN cord-005453-4057qib7 6625 15 realtime realtime NNP cord-005453-4057qib7 6625 16 PCR PCR NNP cord-005453-4057qib7 6625 17 and and CC cord-005453-4057qib7 6625 18 analyzed analyze VBN cord-005453-4057qib7 6625 19 by by IN cord-005453-4057qib7 6625 20 the the DT cord-005453-4057qib7 6625 21 NanoPro1000TM NanoPro1000TM NNP cord-005453-4057qib7 6625 22 system system NN cord-005453-4057qib7 6625 23 . . . cord-005453-4057qib7 6626 1 A a DT cord-005453-4057qib7 6626 2 series series NN cord-005453-4057qib7 6626 3 of of IN cord-005453-4057qib7 6626 4 functional functional JJ cord-005453-4057qib7 6626 5 assays assay NNS cord-005453-4057qib7 6626 6 in in IN cord-005453-4057qib7 6626 7 vitro vitro FW cord-005453-4057qib7 6626 8 were be VBD cord-005453-4057qib7 6626 9 performed perform VBN cord-005453-4057qib7 6626 10 to to TO cord-005453-4057qib7 6626 11 assess assess VB cord-005453-4057qib7 6626 12 the the DT cord-005453-4057qib7 6626 13 function function NN cord-005453-4057qib7 6626 14 and and CC cord-005453-4057qib7 6626 15 stability stability NN cord-005453-4057qib7 6626 16 of of IN cord-005453-4057qib7 6626 17 Tregs Tregs NNP cord-005453-4057qib7 6626 18 from from IN cord-005453-4057qib7 6626 19 patients patient NNS cord-005453-4057qib7 6626 20 with with IN cord-005453-4057qib7 6626 21 and and CC cord-005453-4057qib7 6626 22 without without IN cord-005453-4057qib7 6626 23 aGVHD.Meanwhile aGVHD.Meanwhile NNP cord-005453-4057qib7 6626 24 , , , cord-005453-4057qib7 6626 25 to to TO cord-005453-4057qib7 6626 26 assume assume VB cord-005453-4057qib7 6626 27 the the DT cord-005453-4057qib7 6626 28 affect affect NN cord-005453-4057qib7 6626 29 of of IN cord-005453-4057qib7 6626 30 Lkb1 Lkb1 NNP cord-005453-4057qib7 6626 31 on on IN cord-005453-4057qib7 6626 32 GVHD GVHD NNP cord-005453-4057qib7 6626 33 outcome outcome NN cord-005453-4057qib7 6626 34 , , , cord-005453-4057qib7 6626 35 we -PRON- PRP cord-005453-4057qib7 6626 36 established establish VBD cord-005453-4057qib7 6626 37 a a DT cord-005453-4057qib7 6626 38 murine murine JJ cord-005453-4057qib7 6626 39 transplant transplant NN cord-005453-4057qib7 6626 40 model model NN cord-005453-4057qib7 6626 41 , , , cord-005453-4057qib7 6626 42 which which WDT cord-005453-4057qib7 6626 43 recipient recipient NN cord-005453-4057qib7 6626 44 Balb Balb NNP cord-005453-4057qib7 6626 45 / / SYM cord-005453-4057qib7 6626 46 c c NN cord-005453-4057qib7 6626 47 animals animal NNS cord-005453-4057qib7 6626 48 were be VBD cord-005453-4057qib7 6626 49 transplanted transplant VBN cord-005453-4057qib7 6626 50 with with IN cord-005453-4057qib7 6626 51 the the DT cord-005453-4057qib7 6626 52 same same JJ cord-005453-4057qib7 6626 53 amount amount NN cord-005453-4057qib7 6626 54 of of IN cord-005453-4057qib7 6626 55 mixture mixture NN cord-005453-4057qib7 6626 56 made make VBN cord-005453-4057qib7 6626 57 by by IN cord-005453-4057qib7 6626 58 BM BM NNP cord-005453-4057qib7 6626 59 , , , cord-005453-4057qib7 6626 60 CD4 CD4 NNP cord-005453-4057qib7 6626 61 + + CC cord-005453-4057qib7 6626 62 CD25-Tcon CD25-Tcon NNP cord-005453-4057qib7 6626 63 cells cell NNS cord-005453-4057qib7 6626 64 from from IN cord-005453-4057qib7 6626 65 C57BL/6 C57BL/6 NNP cord-005453-4057qib7 6626 66 and and CC cord-005453-4057qib7 6626 67 CD4 CD4 NNP cord-005453-4057qib7 6627 1 + + CC cord-005453-4057qib7 6627 2 Foxp3 Foxp3 VBN cord-005453-4057qib7 6628 1 YFP+ YFP+ NNP cord-005453-4057qib7 6628 2 Tregs Tregs NNP cord-005453-4057qib7 6628 3 from from IN cord-005453-4057qib7 6628 4 either either DT cord-005453-4057qib7 6628 5 Foxp3CreLkb1f foxp3crelkb1f NN cord-005453-4057qib7 6628 6 / / SYM cord-005453-4057qib7 6628 7 f f NN cord-005453-4057qib7 6628 8 or or CC cord-005453-4057qib7 6628 9 Foxp3Cre foxp3cre JJ cord-005453-4057qib7 6628 10 mice mouse NNS cord-005453-4057qib7 6628 11 . . . cord-005453-4057qib7 6629 1 Results result NNS cord-005453-4057qib7 6629 2 : : : cord-005453-4057qib7 6630 1 In in IN cord-005453-4057qib7 6630 2 this this DT cord-005453-4057qib7 6630 3 study study NN cord-005453-4057qib7 6630 4 , , , cord-005453-4057qib7 6630 5 we -PRON- PRP cord-005453-4057qib7 6630 6 demonstrated demonstrate VBD cord-005453-4057qib7 6630 7 that that IN cord-005453-4057qib7 6630 8 BM BM NNP cord-005453-4057qib7 6630 9 had have VBD cord-005453-4057qib7 6630 10 decreased decrease VBN cord-005453-4057qib7 6630 11 frequencies frequency NNS cord-005453-4057qib7 6630 12 of of IN cord-005453-4057qib7 6630 13 Tregs Tregs NNP cord-005453-4057qib7 6630 14 , , , cord-005453-4057qib7 6630 15 accompanied accompany VBN cord-005453-4057qib7 6630 16 with with IN cord-005453-4057qib7 6630 17 a a DT cord-005453-4057qib7 6630 18 reversed reverse VBN cord-005453-4057qib7 6630 19 lower low JJR cord-005453-4057qib7 6630 20 ratio ratio NN cord-005453-4057qib7 6630 21 of of IN cord-005453-4057qib7 6630 22 Tregs Tregs NNP cord-005453-4057qib7 6630 23 frequencies frequency NNS cord-005453-4057qib7 6630 24 between between IN cord-005453-4057qib7 6630 25 BM BM NNP cord-005453-4057qib7 6630 26 and and CC cord-005453-4057qib7 6630 27 PB PB NNP cord-005453-4057qib7 6630 28 in in IN cord-005453-4057qib7 6630 29 aGVHD aGVHD NNP cord-005453-4057qib7 6630 30 patients patient NNS cord-005453-4057qib7 6630 31 . . . cord-005453-4057qib7 6631 1 Meanwhile meanwhile RB cord-005453-4057qib7 6631 2 , , , cord-005453-4057qib7 6631 3 the the DT cord-005453-4057qib7 6631 4 number number NN cord-005453-4057qib7 6631 5 and and CC cord-005453-4057qib7 6631 6 function function NN cord-005453-4057qib7 6631 7 of of IN cord-005453-4057qib7 6631 8 Tregs Tregs NNP cord-005453-4057qib7 6631 9 in in IN cord-005453-4057qib7 6631 10 bone bone NN cord-005453-4057qib7 6631 11 marrow marrow NN cord-005453-4057qib7 6631 12 also also RB cord-005453-4057qib7 6631 13 affected affect VBD cord-005453-4057qib7 6631 14 hematopoietic hematopoietic JJ cord-005453-4057qib7 6631 15 reconstitution reconstitution NN cord-005453-4057qib7 6631 16 . . . cord-005453-4057qib7 6632 1 Futhermore futhermore RB cord-005453-4057qib7 6632 2 , , , cord-005453-4057qib7 6632 3 to to TO cord-005453-4057qib7 6632 4 elucidate elucidate VB cord-005453-4057qib7 6632 5 these these DT cord-005453-4057qib7 6632 6 mechanisms mechanism NNS cord-005453-4057qib7 6632 7 which which WDT cord-005453-4057qib7 6632 8 regulate regulate VBP cord-005453-4057qib7 6632 9 Tregs Tregs NNP cord-005453-4057qib7 6632 10 homeostasis homeostasis NN cord-005453-4057qib7 6632 11 , , , cord-005453-4057qib7 6632 12 we -PRON- PRP cord-005453-4057qib7 6632 13 examined examine VBD cord-005453-4057qib7 6632 14 the the DT cord-005453-4057qib7 6632 15 role role NN cord-005453-4057qib7 6632 16 of of IN cord-005453-4057qib7 6632 17 Lkb1 Lkb1 NNP cord-005453-4057qib7 6632 18 on on IN cord-005453-4057qib7 6632 19 Tregs Tregs NNP cord-005453-4057qib7 6632 20 in in IN cord-005453-4057qib7 6632 21 patients patient NNS cord-005453-4057qib7 6632 22 with with IN cord-005453-4057qib7 6632 23 aGVHD aGVHD NNP cord-005453-4057qib7 6632 24 and and CC cord-005453-4057qib7 6632 25 in in IN cord-005453-4057qib7 6632 26 aGVHD aGVHD NNP cord-005453-4057qib7 6632 27 murine murine JJ cord-005453-4057qib7 6632 28 model model NN cord-005453-4057qib7 6632 29 . . . cord-005453-4057qib7 6633 1 Studies study NNS cord-005453-4057qib7 6633 2 demonstrated demonstrate VBD cord-005453-4057qib7 6633 3 that that IN cord-005453-4057qib7 6633 4 Lkb1deficient Lkb1deficient NNP cord-005453-4057qib7 6633 5 Tregs Tregs NNP cord-005453-4057qib7 6633 6 lost lose VBD cord-005453-4057qib7 6633 7 Foxp3 foxp3 JJ cord-005453-4057qib7 6633 8 expression expression NN cord-005453-4057qib7 6633 9 and and CC cord-005453-4057qib7 6633 10 weaken weaken VB cord-005453-4057qib7 6633 11 suppressor suppressor NN cord-005453-4057qib7 6633 12 function function NN cord-005453-4057qib7 6633 13 during during IN cord-005453-4057qib7 6633 14 aGVHD aGVHD NNP cord-005453-4057qib7 6633 15 . . . cord-005453-4057qib7 6634 1 Transcriptional transcriptional JJ cord-005453-4057qib7 6634 2 profiling profiling NN cord-005453-4057qib7 6634 3 and and CC cord-005453-4057qib7 6634 4 pathway pathway NN cord-005453-4057qib7 6634 5 analysis analysis NN cord-005453-4057qib7 6634 6 revealed reveal VBD cord-005453-4057qib7 6634 7 that that IN cord-005453-4057qib7 6634 8 NF NF NNP cord-005453-4057qib7 6634 9 - - HYPH cord-005453-4057qib7 6634 10 kB kB NNP cord-005453-4057qib7 6634 11 signaling signal VBG cord-005453-4057qib7 6634 12 activation activation NN cord-005453-4057qib7 6634 13 and and CC cord-005453-4057qib7 6634 14 the the DT cord-005453-4057qib7 6634 15 impairment impairment NN cord-005453-4057qib7 6634 16 of of IN cord-005453-4057qib7 6634 17 a a DT cord-005453-4057qib7 6634 18 wide wide JJ cord-005453-4057qib7 6634 19 spectrum spectrum NN cord-005453-4057qib7 6634 20 of of IN cord-005453-4057qib7 6634 21 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6634 22 genes gene NNS cord-005453-4057qib7 6634 23 in in IN cord-005453-4057qib7 6634 24 aGVHD aGVHD NNP cord-005453-4057qib7 6634 25 Tregs Tregs NNP cord-005453-4057qib7 6634 26 . . . cord-005453-4057qib7 6635 1 Further further JJ cord-005453-4057qib7 6635 2 mice mice NN cord-005453-4057qib7 6635 3 experiments experiment NNS cord-005453-4057qib7 6635 4 suggested suggest VBD cord-005453-4057qib7 6635 5 that that IN cord-005453-4057qib7 6635 6 CNS2 CNS2 NNP cord-005453-4057qib7 6635 7 methylation methylation NN cord-005453-4057qib7 6635 8 might may MD cord-005453-4057qib7 6635 9 lead lead VB cord-005453-4057qib7 6635 10 to to IN cord-005453-4057qib7 6635 11 the the DT cord-005453-4057qib7 6635 12 instability instability NN cord-005453-4057qib7 6635 13 of of IN cord-005453-4057qib7 6635 14 Tregs Tregs NNP cord-005453-4057qib7 6635 15 in in IN cord-005453-4057qib7 6635 16 aGVHD aGVHD NNP cord-005453-4057qib7 6635 17 group group NN cord-005453-4057qib7 6635 18 . . . cord-005453-4057qib7 6636 1 Transplantation transplantation NN cord-005453-4057qib7 6636 2 with with IN cord-005453-4057qib7 6636 3 marrow marrow NN cord-005453-4057qib7 6636 4 grafts graft NNS cord-005453-4057qib7 6636 5 from from IN cord-005453-4057qib7 6636 6 Foxp3CreLkb1f foxp3crelkb1f NN cord-005453-4057qib7 6636 7 / / SYM cord-005453-4057qib7 6636 8 fmice fmice NN cord-005453-4057qib7 6636 9 exacerbates exacerbate VBZ cord-005453-4057qib7 6636 10 GVHD GVHD NNP cord-005453-4057qib7 6636 11 lethality lethality NN cord-005453-4057qib7 6636 12 . . . cord-005453-4057qib7 6637 1 Conclusions conclusion NNS cord-005453-4057qib7 6637 2 : : : cord-005453-4057qib7 6638 1 These these DT cord-005453-4057qib7 6638 2 studies study NNS cord-005453-4057qib7 6638 3 indicate indicate VBP cord-005453-4057qib7 6638 4 that that IN cord-005453-4057qib7 6638 5 Lkb1 Lkb1 NNP cord-005453-4057qib7 6638 6 is be VBZ cord-005453-4057qib7 6638 7 a a DT cord-005453-4057qib7 6638 8 critical critical JJ cord-005453-4057qib7 6638 9 homeostatic homeostatic JJ cord-005453-4057qib7 6638 10 regulator regulator NN cord-005453-4057qib7 6638 11 for for IN cord-005453-4057qib7 6638 12 Tregs Tregs NNP cord-005453-4057qib7 6638 13 during during IN cord-005453-4057qib7 6638 14 aGVHD aGVHD NNP cord-005453-4057qib7 6638 15 . . . cord-005453-4057qib7 6639 1 Targeting target VBG cord-005453-4057qib7 6639 2 of of IN cord-005453-4057qib7 6639 3 Lkb1 Lkb1 NNP cord-005453-4057qib7 6639 4 therefore therefore RB cord-005453-4057qib7 6639 5 represents represent VBZ cord-005453-4057qib7 6639 6 a a DT cord-005453-4057qib7 6639 7 novel novel JJ cord-005453-4057qib7 6639 8 therapeutic therapeutic JJ cord-005453-4057qib7 6639 9 strategy strategy NN cord-005453-4057qib7 6639 10 that that WDT cord-005453-4057qib7 6639 11 promote promote VBP cord-005453-4057qib7 6639 12 immune immune JJ cord-005453-4057qib7 6639 13 tolerance tolerance NN cord-005453-4057qib7 6639 14 to to TO cord-005453-4057qib7 6639 15 mitigates mitigate VBZ cord-005453-4057qib7 6639 16 the the DT cord-005453-4057qib7 6639 17 severity severity NN cord-005453-4057qib7 6639 18 of of IN cord-005453-4057qib7 6639 19 aGVHD aGVHD NNP cord-005453-4057qib7 6639 20 . . . cord-005453-4057qib7 6640 1 Disclosure disclosure NN cord-005453-4057qib7 6640 2 : : : cord-005453-4057qib7 6640 3 National National NNP cord-005453-4057qib7 6640 4 Program Program NNP cord-005453-4057qib7 6640 5 on on IN cord-005453-4057qib7 6640 6 Key Key NNP cord-005453-4057qib7 6640 7 Basic Basic NNP cord-005453-4057qib7 6640 8 Research Research NNP cord-005453-4057qib7 6640 9 Project Project NNP cord-005453-4057qib7 6640 10 ( ( -LRB- cord-005453-4057qib7 6640 11 973 973 CD cord-005453-4057qib7 6640 12 Program Program NNP cord-005453-4057qib7 6640 13 ) ) -RRB- cord-005453-4057qib7 6640 14 Role role NN cord-005453-4057qib7 6640 15 of of IN cord-005453-4057qib7 6640 16 aryl aryl NN cord-005453-4057qib7 6640 17 hydrocarbon hydrocarbon NN cord-005453-4057qib7 6640 18 receptor receptor NN cord-005453-4057qib7 6640 19 in in IN cord-005453-4057qib7 6640 20 intestine intestine NN cord-005453-4057qib7 6640 21 after after IN cord-005453-4057qib7 6640 22 allogeneic allogeneic NN cord-005453-4057qib7 6640 23 HSCT HSCT NNP cord-005453-4057qib7 6640 24 in in IN cord-005453-4057qib7 6640 25 mice mouse NNS cord-005453-4057qib7 6641 1 Won Won NNP cord-005453-4057qib7 6641 2 - - HYPH cord-005453-4057qib7 6641 3 Sik Sik NNP cord-005453-4057qib7 6641 4 Lee Lee NNP cord-005453-4057qib7 6641 5 1 1 CD cord-005453-4057qib7 6641 6 , , , cord-005453-4057qib7 6641 7 Soung Soung NNP cord-005453-4057qib7 6641 8 - - HYPH cord-005453-4057qib7 6641 9 Min Min NNP cord-005453-4057qib7 6641 10 Lee Lee NNP cord-005453-4057qib7 6641 11 1 1 CD cord-005453-4057qib7 6642 1 , , , cord-005453-4057qib7 6642 2 Sj Sj NNP cord-005453-4057qib7 6642 3 - - HYPH cord-005453-4057qib7 6642 4 Kil Kil NNP cord-005453-4057qib7 6642 5 Seo Seo NNP cord-005453-4057qib7 6643 1 1 1 CD cord-005453-4057qib7 6643 2 1 1 CD cord-005453-4057qib7 6643 3 Inje Inje NNP cord-005453-4057qib7 6643 4 University University NNP cord-005453-4057qib7 6643 5 , , , cord-005453-4057qib7 6643 6 Busan Busan NNP cord-005453-4057qib7 6643 7 Paik Paik NNP cord-005453-4057qib7 6643 8 Hospital Hospital NNP cord-005453-4057qib7 6643 9 , , , cord-005453-4057qib7 6643 10 Hemato Hemato NNP cord-005453-4057qib7 6643 11 - - HYPH cord-005453-4057qib7 6643 12 Oncology Oncology NNP cord-005453-4057qib7 6643 13 , , , cord-005453-4057qib7 6643 14 Busan Busan NNP cord-005453-4057qib7 6643 15 , , , cord-005453-4057qib7 6643 16 Korea Korea NNP cord-005453-4057qib7 6643 17 , , , cord-005453-4057qib7 6643 18 Republic Republic NNP cord-005453-4057qib7 6643 19 of of IN cord-005453-4057qib7 6643 20 Background Background NNP cord-005453-4057qib7 6643 21 : : : cord-005453-4057qib7 6643 22 Aryl Aryl NNP cord-005453-4057qib7 6643 23 hydrocarbon hydrocarbon NN cord-005453-4057qib7 6643 24 receptor receptor NN cord-005453-4057qib7 6643 25 ( ( -LRB- cord-005453-4057qib7 6643 26 AhR AhR NNP cord-005453-4057qib7 6643 27 ) ) -RRB- cord-005453-4057qib7 6643 28 is be VBZ cord-005453-4057qib7 6643 29 a a DT cord-005453-4057qib7 6643 30 ligandactivated ligandactivated JJ cord-005453-4057qib7 6643 31 transcription transcription NN cord-005453-4057qib7 6643 32 factor factor NN cord-005453-4057qib7 6643 33 that that WDT cord-005453-4057qib7 6643 34 is be VBZ cord-005453-4057qib7 6643 35 activated activate VBN cord-005453-4057qib7 6643 36 by by IN cord-005453-4057qib7 6643 37 various various JJ cord-005453-4057qib7 6643 38 small small JJ cord-005453-4057qib7 6643 39 molecules molecule NNS cord-005453-4057qib7 6643 40 from from IN cord-005453-4057qib7 6643 41 the the DT cord-005453-4057qib7 6643 42 diet diet NN cord-005453-4057qib7 6643 43 , , , cord-005453-4057qib7 6643 44 microorganisms microorganism NNS cord-005453-4057qib7 6643 45 , , , cord-005453-4057qib7 6643 46 host host NN cord-005453-4057qib7 6643 47 metabolism metabolism NN cord-005453-4057qib7 6643 48 , , , cord-005453-4057qib7 6643 49 and and CC cord-005453-4057qib7 6643 50 xenobiotic xenobiotic JJ cord-005453-4057qib7 6643 51 toxic toxic JJ cord-005453-4057qib7 6643 52 chemicals chemical NNS cord-005453-4057qib7 6643 53 . . . cord-005453-4057qib7 6644 1 The the DT cord-005453-4057qib7 6644 2 function function NN cord-005453-4057qib7 6644 3 of of IN cord-005453-4057qib7 6644 4 AhR AhR NNP cord-005453-4057qib7 6644 5 has have VBZ cord-005453-4057qib7 6644 6 been be VBN cord-005453-4057qib7 6644 7 demonstrated demonstrate VBN cord-005453-4057qib7 6644 8 as as IN cord-005453-4057qib7 6644 9 a a DT cord-005453-4057qib7 6644 10 crucial crucial JJ cord-005453-4057qib7 6644 11 regulator regulator NN cord-005453-4057qib7 6644 12 in in IN cord-005453-4057qib7 6644 13 intestinal intestinal JJ cord-005453-4057qib7 6644 14 homeostasis homeostasis NN cord-005453-4057qib7 6644 15 . . . cord-005453-4057qib7 6645 1 Here here RB cord-005453-4057qib7 6645 2 , , , cord-005453-4057qib7 6645 3 we -PRON- PRP cord-005453-4057qib7 6645 4 investigated investigate VBD cord-005453-4057qib7 6645 5 the the DT cord-005453-4057qib7 6645 6 regulatory regulatory JJ cord-005453-4057qib7 6645 7 role role NN cord-005453-4057qib7 6645 8 of of IN cord-005453-4057qib7 6645 9 AhR ahr NN cord-005453-4057qib7 6645 10 in in IN cord-005453-4057qib7 6645 11 intestine intestine NN cord-005453-4057qib7 6645 12 of of IN cord-005453-4057qib7 6645 13 recipients recipient NNS cord-005453-4057qib7 6645 14 after after IN cord-005453-4057qib7 6645 15 allogeneic allogeneic JJ cord-005453-4057qib7 6645 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 6645 17 cell cell NN cord-005453-4057qib7 6645 18 transplantation transplantation NN cord-005453-4057qib7 6645 19 in in IN cord-005453-4057qib7 6645 20 mice mouse NNS cord-005453-4057qib7 6645 21 . . . cord-005453-4057qib7 6646 1 Methods method NNS cord-005453-4057qib7 6646 2 : : : cord-005453-4057qib7 6647 1 Wild wild JJ cord-005453-4057qib7 6647 2 - - HYPH cord-005453-4057qib7 6647 3 type type NN cord-005453-4057qib7 6647 4 ( ( -LRB- cord-005453-4057qib7 6647 5 WT WT NNP cord-005453-4057qib7 6647 6 ) ) -RRB- cord-005453-4057qib7 6647 7 B6 b6 NN cord-005453-4057qib7 6647 8 ( ( -LRB- cord-005453-4057qib7 6647 9 H-2 H-2 NNP cord-005453-4057qib7 6647 10 b b NN cord-005453-4057qib7 6647 11 ) ) -RRB- cord-005453-4057qib7 6647 12 , , , cord-005453-4057qib7 6647 13 IDO IDO NNP cord-005453-4057qib7 6647 14 -/-(H-2 -/-(H-2 NNP cord-005453-4057qib7 6647 15 b b NN cord-005453-4057qib7 6647 16 ) ) -RRB- cord-005453-4057qib7 6647 17 and and CC cord-005453-4057qib7 6648 1 AhR AhR NNP cord-005453-4057qib7 6648 2 -/-(H-2 -/-(H-2 NNP cord-005453-4057qib7 6648 3 b b NN cord-005453-4057qib7 6648 4 ) ) -RRB- cord-005453-4057qib7 6648 5 mice mouse NNS cord-005453-4057qib7 6648 6 were be VBD cord-005453-4057qib7 6648 7 lethally lethally RB cord-005453-4057qib7 6648 8 irradiated irradiate VBN cord-005453-4057qib7 6648 9 and and CC cord-005453-4057qib7 6648 10 transplanted transplant VBN cord-005453-4057qib7 6648 11 with with IN cord-005453-4057qib7 6648 12 5 5 CD cord-005453-4057qib7 6648 13 x x SYM cord-005453-4057qib7 6648 14 10 10 CD cord-005453-4057qib7 6648 15 6 6 CD cord-005453-4057qib7 6648 16 TCD TCD NNP cord-005453-4057qib7 6648 17 - - HYPH cord-005453-4057qib7 6648 18 BM BM NNP cord-005453-4057qib7 6648 19 plus plus CC cord-005453-4057qib7 6648 20 2 2 CD cord-005453-4057qib7 6648 21 x x SYM cord-005453-4057qib7 6648 22 10 10 CD cord-005453-4057qib7 6648 23 6 6 CD cord-005453-4057qib7 6648 24 T t NN cord-005453-4057qib7 6648 25 cells cell NNS cord-005453-4057qib7 6648 26 from from IN cord-005453-4057qib7 6648 27 BALB BALB NNP cord-005453-4057qib7 6648 28 / / SYM cord-005453-4057qib7 6648 29 c c NNP cord-005453-4057qib7 6648 30 donor donor NN cord-005453-4057qib7 6648 31 mice mouse NNS cord-005453-4057qib7 6648 32 . . . cord-005453-4057qib7 6649 1 AhR AhR NNP cord-005453-4057qib7 6649 2 activation activation NN cord-005453-4057qib7 6649 3 in in IN cord-005453-4057qib7 6649 4 colon colon NN cord-005453-4057qib7 6649 5 tissue tissue NN cord-005453-4057qib7 6649 6 of of IN cord-005453-4057qib7 6649 7 recipients recipient NNS cord-005453-4057qib7 6649 8 was be VBD cord-005453-4057qib7 6649 9 determined determine VBN cord-005453-4057qib7 6649 10 by by IN cord-005453-4057qib7 6649 11 the the DT cord-005453-4057qib7 6649 12 AhR AhR NNP cord-005453-4057qib7 6649 13 target target NN cord-005453-4057qib7 6649 14 genes gene NNS cord-005453-4057qib7 6649 15 CYP1A1 CYP1A1 NNP cord-005453-4057qib7 6649 16 and and CC cord-005453-4057qib7 6649 17 CYP1B1 CYP1B1 NNP cord-005453-4057qib7 6649 18 expression expression NN cord-005453-4057qib7 6649 19 using use VBG cord-005453-4057qib7 6649 20 real real JJ cord-005453-4057qib7 6649 21 - - HYPH cord-005453-4057qib7 6649 22 time time NN cord-005453-4057qib7 6649 23 PCR PCR NNP cord-005453-4057qib7 6649 24 . . . cord-005453-4057qib7 6650 1 The the DT cord-005453-4057qib7 6650 2 recipient recipient NN cord-005453-4057qib7 6650 3 mice mouse NNS cord-005453-4057qib7 6650 4 were be VBD cord-005453-4057qib7 6650 5 monitored monitor VBN cord-005453-4057qib7 6650 6 every every DT cord-005453-4057qib7 6650 7 other other JJ cord-005453-4057qib7 6650 8 day day NN cord-005453-4057qib7 6650 9 for for IN cord-005453-4057qib7 6650 10 survival survival NN cord-005453-4057qib7 6650 11 and and CC cord-005453-4057qib7 6650 12 clinical clinical JJ cord-005453-4057qib7 6650 13 score score NN cord-005453-4057qib7 6650 14 . . . cord-005453-4057qib7 6651 1 Histopathology Histopathology NNP cord-005453-4057qib7 6651 2 and and CC cord-005453-4057qib7 6651 3 pathogenic pathogenic JJ cord-005453-4057qib7 6651 4 effector effector NN cord-005453-4057qib7 6651 5 cytokine cytokine NN cord-005453-4057qib7 6651 6 levels level NNS cord-005453-4057qib7 6651 7 in in IN cord-005453-4057qib7 6651 8 colon colon NN cord-005453-4057qib7 6651 9 tissue tissue NN cord-005453-4057qib7 6651 10 were be VBD cord-005453-4057qib7 6651 11 analyzed analyze VBN cord-005453-4057qib7 6651 12 for for IN cord-005453-4057qib7 6651 13 evaluating evaluate VBG cord-005453-4057qib7 6651 14 AhR ahr JJ cord-005453-4057qib7 6651 15 function function NN cord-005453-4057qib7 6651 16 . . . cord-005453-4057qib7 6652 1 Results result NNS cord-005453-4057qib7 6652 2 : : : cord-005453-4057qib7 6653 1 We -PRON- PRP cord-005453-4057qib7 6653 2 observed observe VBD cord-005453-4057qib7 6653 3 that that IN cord-005453-4057qib7 6653 4 CYP1A1 CYP1A1 NNP cord-005453-4057qib7 6653 5 was be VBD cord-005453-4057qib7 6653 6 constitutively constitutively RB cord-005453-4057qib7 6653 7 expressed express VBN cord-005453-4057qib7 6653 8 in in IN cord-005453-4057qib7 6653 9 the the DT cord-005453-4057qib7 6653 10 colon colon NN cord-005453-4057qib7 6653 11 tissue tissue NN cord-005453-4057qib7 6653 12 of of IN cord-005453-4057qib7 6653 13 naïve naïve JJ cord-005453-4057qib7 6653 14 recipient recipient NN cord-005453-4057qib7 6653 15 mice mouse NNS cord-005453-4057qib7 6653 16 . . . cord-005453-4057qib7 6654 1 Although although IN cord-005453-4057qib7 6654 2 the the DT cord-005453-4057qib7 6654 3 expression expression NN cord-005453-4057qib7 6654 4 levels level NNS cord-005453-4057qib7 6654 5 were be VBD cord-005453-4057qib7 6654 6 increased increase VBN cord-005453-4057qib7 6654 7 by by IN cord-005453-4057qib7 6654 8 TBI TBI NNP cord-005453-4057qib7 6654 9 conditioning conditioning NN cord-005453-4057qib7 6654 10 , , , cord-005453-4057qib7 6654 11 the the DT cord-005453-4057qib7 6654 12 additive additive NN cord-005453-4057qib7 6654 13 up up IN cord-005453-4057qib7 6654 14 - - HYPH cord-005453-4057qib7 6654 15 regulation regulation NN cord-005453-4057qib7 6654 16 of of IN cord-005453-4057qib7 6654 17 its -PRON- PRP$ cord-005453-4057qib7 6654 18 levels level NNS cord-005453-4057qib7 6654 19 with with IN cord-005453-4057qib7 6654 20 donor donor NN cord-005453-4057qib7 6654 21 T t NN cord-005453-4057qib7 6654 22 cell cell NN cord-005453-4057qib7 6654 23 alloreactivity alloreactivity NN cord-005453-4057qib7 6654 24 was be VBD cord-005453-4057qib7 6654 25 not not RB cord-005453-4057qib7 6654 26 observed observe VBN cord-005453-4057qib7 6654 27 . . . cord-005453-4057qib7 6655 1 In in IN cord-005453-4057qib7 6655 2 contrast contrast NN cord-005453-4057qib7 6655 3 , , , cord-005453-4057qib7 6655 4 CYP1B1 CYP1B1 NNP cord-005453-4057qib7 6655 5 expression expression NN cord-005453-4057qib7 6655 6 was be VBD cord-005453-4057qib7 6655 7 markedly markedly RB cord-005453-4057qib7 6655 8 induced induce VBN cord-005453-4057qib7 6655 9 in in IN cord-005453-4057qib7 6655 10 the the DT cord-005453-4057qib7 6655 11 colon colon NN cord-005453-4057qib7 6655 12 tissue tissue NN cord-005453-4057qib7 6655 13 by by IN cord-005453-4057qib7 6655 14 donor donor NN cord-005453-4057qib7 6655 15 T t NN cord-005453-4057qib7 6655 16 cell cell NN cord-005453-4057qib7 6655 17 alloreactivity alloreactivity NN cord-005453-4057qib7 6655 18 . . . cord-005453-4057qib7 6656 1 We -PRON- PRP cord-005453-4057qib7 6656 2 further further RB cord-005453-4057qib7 6656 3 observed observe VBD cord-005453-4057qib7 6656 4 that that IN cord-005453-4057qib7 6656 5 the the DT cord-005453-4057qib7 6656 6 CYP1B1 CYP1B1 NNP cord-005453-4057qib7 6656 7 expression expression NN cord-005453-4057qib7 6656 8 was be VBD cord-005453-4057qib7 6656 9 significantly significantly RB cord-005453-4057qib7 6656 10 decreased decrease VBN cord-005453-4057qib7 6656 11 in in IN cord-005453-4057qib7 6656 12 the the DT cord-005453-4057qib7 6656 13 colon colon NN cord-005453-4057qib7 6656 14 of of IN cord-005453-4057qib7 6656 15 IDO-/-recipients ido-/-recipient NNS cord-005453-4057qib7 6656 16 with with IN cord-005453-4057qib7 6656 17 donor donor NN cord-005453-4057qib7 6656 18 T t NN cord-005453-4057qib7 6656 19 cell cell NN cord-005453-4057qib7 6656 20 alloreactivity alloreactivity NN cord-005453-4057qib7 6656 21 , , , cord-005453-4057qib7 6656 22 but but CC cord-005453-4057qib7 6656 23 CYP1A1 CYP1A1 NNP cord-005453-4057qib7 6656 24 was be VBD cord-005453-4057qib7 6656 25 not not RB cord-005453-4057qib7 6656 26 changed change VBN cord-005453-4057qib7 6656 27 . . . cord-005453-4057qib7 6657 1 IDO-/-and ido-/-and NN cord-005453-4057qib7 6657 2 AhR-/recipient ahr-/recipient CD cord-005453-4057qib7 6657 3 mice mouse NNS cord-005453-4057qib7 6657 4 showed show VBD cord-005453-4057qib7 6657 5 higher high JJR cord-005453-4057qib7 6657 6 histopathological histopathological JJ cord-005453-4057qib7 6657 7 score score NN cord-005453-4057qib7 6657 8 for for IN cord-005453-4057qib7 6657 9 intestinal intestinal JJ cord-005453-4057qib7 6657 10 GVHD GVHD NNP cord-005453-4057qib7 6657 11 and and CC cord-005453-4057qib7 6657 12 increasing increase VBG cord-005453-4057qib7 6657 13 pathogenic pathogenic JJ cord-005453-4057qib7 6657 14 cytokine cytokine NN cord-005453-4057qib7 6657 15 levels level NNS cord-005453-4057qib7 6657 16 in in IN cord-005453-4057qib7 6657 17 the the DT cord-005453-4057qib7 6657 18 colon colon NN cord-005453-4057qib7 6657 19 compared compare VBN cord-005453-4057qib7 6657 20 with with IN cord-005453-4057qib7 6657 21 WT WT NNP cord-005453-4057qib7 6657 22 mice mouse NNS cord-005453-4057qib7 6657 23 . . . cord-005453-4057qib7 6658 1 Conclusions conclusion NNS cord-005453-4057qib7 6658 2 : : : cord-005453-4057qib7 6659 1 Our -PRON- PRP$ cord-005453-4057qib7 6659 2 results result NNS cord-005453-4057qib7 6659 3 demonstrate demonstrate VBP cord-005453-4057qib7 6659 4 that that IN cord-005453-4057qib7 6659 5 AhR ahr NN cord-005453-4057qib7 6659 6 - - HYPH cord-005453-4057qib7 6659 7 induced induce VBN cord-005453-4057qib7 6659 8 target target NN cord-005453-4057qib7 6659 9 gene gene NN cord-005453-4057qib7 6659 10 profiles profile NNS cord-005453-4057qib7 6659 11 might may MD cord-005453-4057qib7 6659 12 be be VB cord-005453-4057qib7 6659 13 differently differently RB cord-005453-4057qib7 6659 14 induced induce VBN cord-005453-4057qib7 6659 15 in in IN cord-005453-4057qib7 6659 16 intestine intestine NN cord-005453-4057qib7 6659 17 by by IN cord-005453-4057qib7 6659 18 ligand ligand NN cord-005453-4057qib7 6659 19 dependent dependent JJ cord-005453-4057qib7 6659 20 manner manner NN cord-005453-4057qib7 6659 21 after after IN cord-005453-4057qib7 6659 22 HSCT HSCT NNP cord-005453-4057qib7 6659 23 , , , cord-005453-4057qib7 6659 24 which which WDT cord-005453-4057qib7 6659 25 affect affect VBP cord-005453-4057qib7 6659 26 intestinal intestinal JJ cord-005453-4057qib7 6659 27 GVHD GVHD NNP cord-005453-4057qib7 6659 28 . . . cord-005453-4057qib7 6660 1 Disclosure disclosure NN cord-005453-4057qib7 6660 2 : : : cord-005453-4057qib7 6660 3 Nothing nothing NN cord-005453-4057qib7 6660 4 to to TO cord-005453-4057qib7 6660 5 declare declare VB cord-005453-4057qib7 6660 6 . . . cord-005453-4057qib7 6661 1 Abstract Abstract NNP cord-005453-4057qib7 6661 2 already already RB cord-005453-4057qib7 6661 3 published publish VBN cord-005453-4057qib7 6661 4 . . . cord-005453-4057qib7 6662 1 Abstract Abstract NNP cord-005453-4057qib7 6662 2 withdrawn withdraw VBN cord-005453-4057qib7 6662 3 . . . cord-005453-4057qib7 6663 1 In in IN cord-005453-4057qib7 6663 2 vitro vitro FW cord-005453-4057qib7 6663 3 platelet platelet NN cord-005453-4057qib7 6663 4 activation activation NN cord-005453-4057qib7 6663 5 evaluation evaluation NN cord-005453-4057qib7 6663 6 in in IN cord-005453-4057qib7 6663 7 allogeneic allogeneic JJ cord-005453-4057qib7 6663 8 hematopoetic hematopoetic JJ cord-005453-4057qib7 6663 9 stem stem NN cord-005453-4057qib7 6663 10 cell cell NN cord-005453-4057qib7 6663 11 transplanted transplant VBN cord-005453-4057qib7 6663 12 patients patient NNS cord-005453-4057qib7 6663 13 in in IN cord-005453-4057qib7 6663 14 response response NN cord-005453-4057qib7 6663 15 to to IN cord-005453-4057qib7 6663 16 haemostatic haemostatic JJ cord-005453-4057qib7 6663 17 stimulation stimulation NN cord-005453-4057qib7 6663 18 and and CC cord-005453-4057qib7 6663 19 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 6663 20 stimulation stimulation NN cord-005453-4057qib7 6663 21 ( ( -LRB- cord-005453-4057qib7 6663 22 GvHD GvHD NNP cord-005453-4057qib7 6663 23 ) ) -RRB- cord-005453-4057qib7 6663 24 , , , cord-005453-4057qib7 6663 25 complication complication NN cord-005453-4057qib7 6663 26 of of IN cord-005453-4057qib7 6663 27 which which WDT cord-005453-4057qib7 6663 28 one one CD cord-005453-4057qib7 6663 29 of of IN cord-005453-4057qib7 6663 30 the the DT cord-005453-4057qib7 6663 31 risk risk NN cord-005453-4057qib7 6663 32 factor factor NN cord-005453-4057qib7 6663 33 is be VBZ cord-005453-4057qib7 6663 34 CMV CMV NNP cord-005453-4057qib7 6663 35 reactivation reactivation NN cord-005453-4057qib7 6663 36 . . . cord-005453-4057qib7 6664 1 The the DT cord-005453-4057qib7 6664 2 resultant resultant JJ cord-005453-4057qib7 6664 3 inflammatory inflammatory JJ cord-005453-4057qib7 6664 4 platelet platelet NN cord-005453-4057qib7 6664 5 response response NN cord-005453-4057qib7 6664 6 during during IN cord-005453-4057qib7 6664 7 the the DT cord-005453-4057qib7 6664 8 high high JJ cord-005453-4057qib7 6664 9 - - HYPH cord-005453-4057qib7 6664 10 risk risk NN cord-005453-4057qib7 6664 11 period period NN cord-005453-4057qib7 6664 12 of of IN cord-005453-4057qib7 6664 13 GvHD GvHD NNP cord-005453-4057qib7 6664 14 after after IN cord-005453-4057qib7 6664 15 allogeneic allogeneic NN cord-005453-4057qib7 6664 16 HSCT HSCT NNP cord-005453-4057qib7 6664 17 remains remain VBZ cord-005453-4057qib7 6664 18 unknown unknown JJ cord-005453-4057qib7 6664 19 . . . cord-005453-4057qib7 6665 1 Our -PRON- PRP$ cord-005453-4057qib7 6665 2 study study NN cord-005453-4057qib7 6665 3 aimed aim VBD cord-005453-4057qib7 6665 4 to to TO cord-005453-4057qib7 6665 5 characterize characterize VB cord-005453-4057qib7 6665 6 spontaneous spontaneous JJ cord-005453-4057qib7 6665 7 platelet platelet NN cord-005453-4057qib7 6665 8 activation activation NN cord-005453-4057qib7 6665 9 during during IN cord-005453-4057qib7 6665 10 the the DT cord-005453-4057qib7 6665 11 2d 2d NNP cord-005453-4057qib7 6665 12 and and CC cord-005453-4057qib7 6665 13 3d 3d JJ cord-005453-4057qib7 6665 14 months month NNS cord-005453-4057qib7 6665 15 after after IN cord-005453-4057qib7 6665 16 allogeneic allogeneic NN cord-005453-4057qib7 6665 17 HSCT HSCT NNP cord-005453-4057qib7 6665 18 , , , cord-005453-4057qib7 6665 19 and and CC cord-005453-4057qib7 6665 20 in in IN cord-005453-4057qib7 6665 21 response response NN cord-005453-4057qib7 6665 22 to to IN cord-005453-4057qib7 6665 23 haemostatic haemostatic JJ cord-005453-4057qib7 6665 24 stimulation stimulation NN cord-005453-4057qib7 6665 25 and and CC cord-005453-4057qib7 6665 26 CMV CMV NNP cord-005453-4057qib7 6665 27 stimulation stimulation NN cord-005453-4057qib7 6665 28 . . . cord-005453-4057qib7 6666 1 Methods method NNS cord-005453-4057qib7 6666 2 : : : cord-005453-4057qib7 6667 1 We -PRON- PRP cord-005453-4057qib7 6667 2 compared compare VBD cord-005453-4057qib7 6667 3 a a DT cord-005453-4057qib7 6667 4 group group NN cord-005453-4057qib7 6667 5 of of IN cord-005453-4057qib7 6667 6 healthy healthy JJ cord-005453-4057qib7 6667 7 volunteers volunteer NNS cord-005453-4057qib7 6667 8 to to IN cord-005453-4057qib7 6667 9 a a DT cord-005453-4057qib7 6667 10 group group NN cord-005453-4057qib7 6667 11 of of IN cord-005453-4057qib7 6667 12 allogeneic allogeneic JJ cord-005453-4057qib7 6667 13 HSCT HSCT NNP cord-005453-4057qib7 6667 14 patients patient NNS cord-005453-4057qib7 6667 15 followed follow VBD cord-005453-4057qib7 6667 16 between between IN cord-005453-4057qib7 6667 17 the the DT cord-005453-4057qib7 6667 18 30 30 CD cord-005453-4057qib7 6667 19 th th XX cord-005453-4057qib7 6667 20 and and CC cord-005453-4057qib7 6667 21 the the DT cord-005453-4057qib7 6667 22 90 90 CD cord-005453-4057qib7 6667 23 th th XX cord-005453-4057qib7 6667 24 days day NNS cord-005453-4057qib7 6667 25 after after IN cord-005453-4057qib7 6667 26 HSCT HSCT NNP cord-005453-4057qib7 6667 27 . . . cord-005453-4057qib7 6668 1 Platelet platelet NN cord-005453-4057qib7 6668 2 activation activation NN cord-005453-4057qib7 6668 3 was be VBD cord-005453-4057qib7 6668 4 determined determine VBN cord-005453-4057qib7 6668 5 by by IN cord-005453-4057qib7 6668 6 the the DT cord-005453-4057qib7 6668 7 platelet platelet NN cord-005453-4057qib7 6668 8 surface surface NN cord-005453-4057qib7 6668 9 expression expression NN cord-005453-4057qib7 6668 10 of of IN cord-005453-4057qib7 6668 11 CD62P cd62p NN cord-005453-4057qib7 6668 12 and and CC cord-005453-4057qib7 6668 13 CD63 CD63 NNP cord-005453-4057qib7 6668 14 using use VBG cord-005453-4057qib7 6668 15 flow flow NN cord-005453-4057qib7 6668 16 cytometer cytometer NN cord-005453-4057qib7 6668 17 after after IN cord-005453-4057qib7 6668 18 stimulation stimulation NN cord-005453-4057qib7 6668 19 by by IN cord-005453-4057qib7 6668 20 an an DT cord-005453-4057qib7 6668 21 haemostatic haemostatic JJ cord-005453-4057qib7 6668 22 agent agent NN cord-005453-4057qib7 6668 23 , , , cord-005453-4057qib7 6668 24 Thrombin Thrombin NNP cord-005453-4057qib7 6668 25 - - HYPH cord-005453-4057qib7 6668 26 receptor receptor NN cord-005453-4057qib7 6668 27 activating activate VBG cord-005453-4057qib7 6668 28 Peptid Peptid NNP cord-005453-4057qib7 6668 29 ( ( -LRB- cord-005453-4057qib7 6668 30 TRAP TRAP NNP cord-005453-4057qib7 6668 31 ) ) -RRB- cord-005453-4057qib7 6668 32 and and CC cord-005453-4057qib7 6668 33 after after IN cord-005453-4057qib7 6668 34 stimulation stimulation NN cord-005453-4057qib7 6668 35 by by IN cord-005453-4057qib7 6668 36 CMV CMV NNP cord-005453-4057qib7 6668 37 glycoprotein glycoprotein NN cord-005453-4057qib7 6669 1 B. B. NNP cord-005453-4057qib7 6670 1 The the DT cord-005453-4057qib7 6670 2 inflammatory inflammatory JJ cord-005453-4057qib7 6670 3 response response NN cord-005453-4057qib7 6670 4 was be VBD cord-005453-4057qib7 6670 5 determined determine VBN cord-005453-4057qib7 6670 6 by by IN cord-005453-4057qib7 6670 7 the the DT cord-005453-4057qib7 6670 8 detection detection NN cord-005453-4057qib7 6670 9 of of IN cord-005453-4057qib7 6670 10 immune immune JJ cord-005453-4057qib7 6670 11 mediators mediator NNS cord-005453-4057qib7 6670 12 , , , cord-005453-4057qib7 6670 13 RANTES rante NNS cord-005453-4057qib7 6670 14 , , , cord-005453-4057qib7 6670 15 CD62Ps cd62ps UH cord-005453-4057qib7 6670 16 , , , cord-005453-4057qib7 6670 17 PF4 pf4 UH cord-005453-4057qib7 6670 18 , , , cord-005453-4057qib7 6670 19 CD40L cd40l NN cord-005453-4057qib7 6670 20 and and CC cord-005453-4057qib7 6670 21 CCL3 CCL3 NNP cord-005453-4057qib7 6670 22 , , , cord-005453-4057qib7 6670 23 using use VBG cord-005453-4057qib7 6670 24 the the DT cord-005453-4057qib7 6670 25 ELISA ELISA NNP cord-005453-4057qib7 6670 26 technique technique NN cord-005453-4057qib7 6670 27 in in IN cord-005453-4057qib7 6670 28 the the DT cord-005453-4057qib7 6670 29 stimulated stimulated JJ cord-005453-4057qib7 6670 30 platelet platelet NN cord-005453-4057qib7 6670 31 supernatants supernatant NNS cord-005453-4057qib7 6670 32 . . . cord-005453-4057qib7 6671 1 Results result NNS cord-005453-4057qib7 6671 2 : : : cord-005453-4057qib7 6672 1 No no DT cord-005453-4057qib7 6672 2 platelet platelet NN cord-005453-4057qib7 6672 3 activation activation NN cord-005453-4057qib7 6672 4 or or CC cord-005453-4057qib7 6672 5 molecules molecule NNS cord-005453-4057qib7 6672 6 release release NN cord-005453-4057qib7 6672 7 were be VBD cord-005453-4057qib7 6672 8 observed observe VBN cord-005453-4057qib7 6672 9 after after IN cord-005453-4057qib7 6672 10 stimulation stimulation NN cord-005453-4057qib7 6672 11 by by IN cord-005453-4057qib7 6672 12 CMV CMV NNP cord-005453-4057qib7 6672 13 glycoprotein glycoprotein NN cord-005453-4057qib7 6672 14 B b NN cord-005453-4057qib7 6672 15 in in IN cord-005453-4057qib7 6672 16 both both DT cord-005453-4057qib7 6672 17 groups group NNS cord-005453-4057qib7 6672 18 . . . cord-005453-4057qib7 6673 1 RANTES RANTES NNPS cord-005453-4057qib7 6673 2 and and CC cord-005453-4057qib7 6673 3 CD62Ps cd62ps VB cord-005453-4057qib7 6673 4 baseline baseline JJ cord-005453-4057qib7 6673 5 levels level NNS cord-005453-4057qib7 6673 6 are be VBP cord-005453-4057qib7 6673 7 spontaneously spontaneously RB cord-005453-4057qib7 6673 8 higher high JJR cord-005453-4057qib7 6673 9 in in IN cord-005453-4057qib7 6673 10 allogeneic allogeneic JJ cord-005453-4057qib7 6673 11 HSC HSC NNP cord-005453-4057qib7 6673 12 patients patient NNS cord-005453-4057qib7 6673 13 than than IN cord-005453-4057qib7 6673 14 in in IN cord-005453-4057qib7 6673 15 healthy healthy JJ cord-005453-4057qib7 6673 16 volunteers volunteer NNS cord-005453-4057qib7 6673 17 . . . cord-005453-4057qib7 6674 1 Platelets platelet NNS cord-005453-4057qib7 6674 2 from from IN cord-005453-4057qib7 6674 3 allogeneic allogeneic VBG cord-005453-4057qib7 6674 4 HSCT HSCT NNP cord-005453-4057qib7 6674 5 patients patient NNS cord-005453-4057qib7 6674 6 can can MD cord-005453-4057qib7 6674 7 be be VB cord-005453-4057qib7 6674 8 activated activate VBN cord-005453-4057qib7 6674 9 after after IN cord-005453-4057qib7 6674 10 haemostatic haemostatic JJ cord-005453-4057qib7 6674 11 stimulation stimulation NN cord-005453-4057qib7 6674 12 and and CC cord-005453-4057qib7 6674 13 release release NN cord-005453-4057qib7 6674 14 CD62Ps cd62ps NN cord-005453-4057qib7 6674 15 and and CC cord-005453-4057qib7 6674 16 RANTES RANTES NNPS cord-005453-4057qib7 6674 17 . . . cord-005453-4057qib7 6675 1 In in IN cord-005453-4057qib7 6675 2 this this DT cord-005453-4057qib7 6675 3 situation situation NN cord-005453-4057qib7 6675 4 , , , cord-005453-4057qib7 6675 5 platelets platelet NNS cord-005453-4057qib7 6675 6 release release VBP cord-005453-4057qib7 6675 7 more more JJR cord-005453-4057qib7 6675 8 CD62PS CD62PS NNP cord-005453-4057qib7 6675 9 , , , cord-005453-4057qib7 6675 10 RANTES rante NNS cord-005453-4057qib7 6675 11 and and CC cord-005453-4057qib7 6675 12 PF4 pf4 NN cord-005453-4057qib7 6675 13 than than IN cord-005453-4057qib7 6675 14 platelets platelet NNS cord-005453-4057qib7 6675 15 from from IN cord-005453-4057qib7 6675 16 healthy healthy JJ cord-005453-4057qib7 6675 17 volunteers volunteer NNS cord-005453-4057qib7 6675 18 . . . cord-005453-4057qib7 6676 1 Conclusions conclusion NNS cord-005453-4057qib7 6676 2 : : : cord-005453-4057qib7 6677 1 Although although IN cord-005453-4057qib7 6677 2 no no DT cord-005453-4057qib7 6677 3 platelet platelet NN cord-005453-4057qib7 6677 4 activation activation NN cord-005453-4057qib7 6677 5 was be VBD cord-005453-4057qib7 6677 6 detected detect VBN cord-005453-4057qib7 6677 7 in in IN cord-005453-4057qib7 6677 8 response response NN cord-005453-4057qib7 6677 9 to to IN cord-005453-4057qib7 6677 10 CMV CMV NNP cord-005453-4057qib7 6677 11 glycoprotein glycoprotein NN cord-005453-4057qib7 6677 12 B b NN cord-005453-4057qib7 6677 13 stimulation stimulation NN cord-005453-4057qib7 6677 14 , , , cord-005453-4057qib7 6677 15 our -PRON- PRP$ cord-005453-4057qib7 6677 16 study study NN cord-005453-4057qib7 6677 17 revealed reveal VBD cord-005453-4057qib7 6677 18 a a DT cord-005453-4057qib7 6677 19 chronic chronic JJ cord-005453-4057qib7 6677 20 platelet platelet NN cord-005453-4057qib7 6677 21 activation activation NN cord-005453-4057qib7 6677 22 condition condition NN cord-005453-4057qib7 6677 23 during during IN cord-005453-4057qib7 6677 24 the the DT cord-005453-4057qib7 6677 25 2d 2d NNP cord-005453-4057qib7 6677 26 and and CC cord-005453-4057qib7 6677 27 3d 3d JJ cord-005453-4057qib7 6677 28 months month NNS cord-005453-4057qib7 6677 29 after after IN cord-005453-4057qib7 6677 30 allogeneic allogeneic NN cord-005453-4057qib7 6677 31 HSCT HSCT NNP cord-005453-4057qib7 6677 32 with with IN cord-005453-4057qib7 6677 33 an an DT cord-005453-4057qib7 6677 34 haemostatic haemostatic JJ cord-005453-4057qib7 6677 35 inducible inducible JJ cord-005453-4057qib7 6677 36 hyper hyper NN cord-005453-4057qib7 6677 37 - - NN cord-005453-4057qib7 6677 38 responsiveness responsiveness NN cord-005453-4057qib7 6677 39 . . . cord-005453-4057qib7 6678 1 This this DT cord-005453-4057qib7 6678 2 leads lead VBZ cord-005453-4057qib7 6678 3 to to IN cord-005453-4057qib7 6678 4 the the DT cord-005453-4057qib7 6678 5 release release NN cord-005453-4057qib7 6678 6 of of IN cord-005453-4057qib7 6678 7 molecules molecule NNS cord-005453-4057qib7 6678 8 with with IN cord-005453-4057qib7 6678 9 immune immune NN cord-005453-4057qib7 6678 10 - - HYPH cord-005453-4057qib7 6678 11 modulating modulate VBG cord-005453-4057qib7 6678 12 properties property NNS cord-005453-4057qib7 6678 13 involved involve VBN cord-005453-4057qib7 6678 14 in in IN cord-005453-4057qib7 6678 15 the the DT cord-005453-4057qib7 6678 16 pathophysiology pathophysiology NN cord-005453-4057qib7 6678 17 of of IN cord-005453-4057qib7 6678 18 GvHD GvHD NNP cord-005453-4057qib7 6678 19 . . . cord-005453-4057qib7 6679 1 As as IN cord-005453-4057qib7 6679 2 we -PRON- PRP cord-005453-4057qib7 6679 3 move move VBP cord-005453-4057qib7 6679 4 further further RB cord-005453-4057qib7 6679 5 away away RB cord-005453-4057qib7 6679 6 from from IN cord-005453-4057qib7 6679 7 the the DT cord-005453-4057qib7 6679 8 HSCT HSCT NNP cord-005453-4057qib7 6679 9 , , , cord-005453-4057qib7 6679 10 that that DT cord-005453-4057qib7 6679 11 phenomenon phenomenon NN cord-005453-4057qib7 6679 12 seems seem VBZ cord-005453-4057qib7 6679 13 to to TO cord-005453-4057qib7 6679 14 gradually gradually RB cord-005453-4057qib7 6679 15 weaken weaken VB cord-005453-4057qib7 6679 16 . . . cord-005453-4057qib7 6680 1 Clinical clinical JJ cord-005453-4057qib7 6680 2 Trial Trial NNP cord-005453-4057qib7 6680 3 Registry Registry NNP cord-005453-4057qib7 6680 4 : : : cord-005453-4057qib7 6681 1 NCT03009708 NCT03009708 NNP cord-005453-4057qib7 6681 2 , , , cord-005453-4057qib7 6681 3 FIPALLOC FIPALLOC NNP cord-005453-4057qib7 6681 4 https://clinicaltrials.gov/ct2/show/NCT03009708 https://clinicaltrials.gov/ct2/show/NCT03009708 NNP cord-005453-4057qib7 6681 5 Disclosure Disclosure NNP cord-005453-4057qib7 6681 6 : : : cord-005453-4057qib7 6681 7 Nothing nothing NN cord-005453-4057qib7 6681 8 to to TO cord-005453-4057qib7 6681 9 declare declare VB cord-005453-4057qib7 6681 10 P305 P305 NNP cord-005453-4057qib7 6681 11 Efficient efficient JJ cord-005453-4057qib7 6681 12 process process NN cord-005453-4057qib7 6681 13 and and CC cord-005453-4057qib7 6681 14 characteristics characteristic NNS cord-005453-4057qib7 6681 15 of of IN cord-005453-4057qib7 6681 16 umbilical umbilical JJ cord-005453-4057qib7 6681 17 cordderived cordderived JJ cord-005453-4057qib7 6681 18 mesenchymal mesenchymal JJ cord-005453-4057qib7 6681 19 stromal stromal JJ cord-005453-4057qib7 6681 20 cells cell NNS cord-005453-4057qib7 6681 21 as as IN cord-005453-4057qib7 6681 22 a a DT cord-005453-4057qib7 6681 23 feasible feasible JJ cord-005453-4057qib7 6681 24 source source NN cord-005453-4057qib7 6681 25 for for IN cord-005453-4057qib7 6681 26 anti anti JJ cord-005453-4057qib7 6681 27 - - JJ cord-005453-4057qib7 6681 28 inflammatory inflammatory JJ cord-005453-4057qib7 6681 29 therapy therapy NN cord-005453-4057qib7 6681 30 Background background NN cord-005453-4057qib7 6681 31 : : : cord-005453-4057qib7 6682 1 Recently recently RB cord-005453-4057qib7 6682 2 , , , cord-005453-4057qib7 6682 3 umbilical umbilical JJ cord-005453-4057qib7 6682 4 cord cord NN cord-005453-4057qib7 6682 5 ( ( -LRB- cord-005453-4057qib7 6682 6 UC UC NNP cord-005453-4057qib7 6682 7 ) ) -RRB- cord-005453-4057qib7 6682 8 has have VBZ cord-005453-4057qib7 6682 9 become become VBN cord-005453-4057qib7 6682 10 attracted attract VBN cord-005453-4057qib7 6682 11 source source NN cord-005453-4057qib7 6682 12 of of IN cord-005453-4057qib7 6682 13 mesenchymal mesenchymal JJ cord-005453-4057qib7 6682 14 stromal stromal JJ cord-005453-4057qib7 6682 15 cells cell NNS cord-005453-4057qib7 6682 16 ( ( -LRB- cord-005453-4057qib7 6682 17 MSC MSC NNP cord-005453-4057qib7 6682 18 ) ) -RRB- cord-005453-4057qib7 6682 19 , , , cord-005453-4057qib7 6682 20 because because IN cord-005453-4057qib7 6682 21 of of IN cord-005453-4057qib7 6682 22 abundant abundant JJ cord-005453-4057qib7 6682 23 sources source NNS cord-005453-4057qib7 6682 24 and and CC cord-005453-4057qib7 6682 25 ease ease NN cord-005453-4057qib7 6682 26 of of IN cord-005453-4057qib7 6682 27 collection collection NN cord-005453-4057qib7 6682 28 of of IN cord-005453-4057qib7 6682 29 fetal fetal JJ cord-005453-4057qib7 6682 30 origin origin NN cord-005453-4057qib7 6682 31 without without IN cord-005453-4057qib7 6682 32 invasive invasive JJ cord-005453-4057qib7 6682 33 process process NN cord-005453-4057qib7 6682 34 for for IN cord-005453-4057qib7 6682 35 the the DT cord-005453-4057qib7 6682 36 donor donor NN cord-005453-4057qib7 6682 37 and and CC cord-005453-4057qib7 6682 38 low low JJ cord-005453-4057qib7 6682 39 immunogenicity immunogenicity NN cord-005453-4057qib7 6682 40 with with IN cord-005453-4057qib7 6682 41 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6682 42 ability ability NN cord-005453-4057qib7 6682 43 and and CC cord-005453-4057qib7 6682 44 tissue tissue NN cord-005453-4057qib7 6682 45 repair repair NN cord-005453-4057qib7 6682 46 potency potency NN cord-005453-4057qib7 6682 47 . . . cord-005453-4057qib7 6683 1 Objectives objective NNS cord-005453-4057qib7 6683 2 of of IN cord-005453-4057qib7 6683 3 this this DT cord-005453-4057qib7 6683 4 study study NN cord-005453-4057qib7 6683 5 were be VBD cord-005453-4057qib7 6683 6 to to TO cord-005453-4057qib7 6683 7 explorer explorer VB cord-005453-4057qib7 6683 8 the the DT cord-005453-4057qib7 6683 9 efficient efficient JJ cord-005453-4057qib7 6683 10 and and CC cord-005453-4057qib7 6683 11 safe safe JJ cord-005453-4057qib7 6683 12 products product NNS cord-005453-4057qib7 6683 13 and and CC cord-005453-4057qib7 6683 14 to to TO cord-005453-4057qib7 6683 15 evaluate evaluate VB cord-005453-4057qib7 6683 16 the the DT cord-005453-4057qib7 6683 17 antiinflammatory antiinflammatory JJ cord-005453-4057qib7 6683 18 potency potency NN cord-005453-4057qib7 6683 19 of of IN cord-005453-4057qib7 6683 20 UC UC NNP cord-005453-4057qib7 6683 21 - - HYPH cord-005453-4057qib7 6683 22 MSCs MSCs NNP cord-005453-4057qib7 6683 23 for for IN cord-005453-4057qib7 6683 24 the the DT cord-005453-4057qib7 6683 25 application application NN cord-005453-4057qib7 6683 26 of of IN cord-005453-4057qib7 6683 27 acute acute JJ cord-005453-4057qib7 6683 28 graft graft NN cord-005453-4057qib7 6683 29 versus versus IN cord-005453-4057qib7 6683 30 host host NN cord-005453-4057qib7 6683 31 disease disease NN cord-005453-4057qib7 6683 32 ( ( -LRB- cord-005453-4057qib7 6683 33 GVHD GVHD NNP cord-005453-4057qib7 6683 34 ) ) -RRB- cord-005453-4057qib7 6683 35 . . . cord-005453-4057qib7 6684 1 Methods method NNS cord-005453-4057qib7 6684 2 : : : cord-005453-4057qib7 6685 1 Informed informed JJ cord-005453-4057qib7 6685 2 consent consent NN cord-005453-4057qib7 6685 3 was be VBD cord-005453-4057qib7 6685 4 obtained obtain VBN cord-005453-4057qib7 6685 5 from from IN cord-005453-4057qib7 6685 6 mothers mother NNS cord-005453-4057qib7 6685 7 planning plan VBG cord-005453-4057qib7 6685 8 to to TO cord-005453-4057qib7 6685 9 have have VB cord-005453-4057qib7 6685 10 cesarean cesarean NN cord-005453-4057qib7 6685 11 sections section NNS cord-005453-4057qib7 6685 12 . . . cord-005453-4057qib7 6686 1 UC UC NNP cord-005453-4057qib7 6686 2 tissue tissue NN cord-005453-4057qib7 6686 3 was be VBD cord-005453-4057qib7 6686 4 cut cut VBN cord-005453-4057qib7 6686 5 and and CC cord-005453-4057qib7 6686 6 once once RB cord-005453-4057qib7 6686 7 cryopreserved cryopreserve VBN cord-005453-4057qib7 6686 8 . . . cord-005453-4057qib7 6687 1 The the DT cord-005453-4057qib7 6687 2 safety safety NN cord-005453-4057qib7 6687 3 assessment assessment NN cord-005453-4057qib7 6687 4 including include VBG cord-005453-4057qib7 6687 5 infections infection NNS cord-005453-4057qib7 6687 6 and and CC cord-005453-4057qib7 6687 7 baby baby NN cord-005453-4057qib7 6687 8 's 's POS cord-005453-4057qib7 6687 9 health health NN cord-005453-4057qib7 6687 10 and and CC cord-005453-4057qib7 6687 11 development development NN cord-005453-4057qib7 6687 12 were be VBD cord-005453-4057qib7 6687 13 done do VBN cord-005453-4057qib7 6687 14 after after IN cord-005453-4057qib7 6687 15 6 6 CD cord-005453-4057qib7 6687 16 months month NNS cord-005453-4057qib7 6687 17 of of IN cord-005453-4057qib7 6687 18 birth birth NN cord-005453-4057qib7 6687 19 , , , cord-005453-4057qib7 6687 20 and and CC cord-005453-4057qib7 6687 21 performed perform VBD cord-005453-4057qib7 6687 22 small small JJ cord-005453-4057qib7 6687 23 - - HYPH cord-005453-4057qib7 6687 24 scale scale NN cord-005453-4057qib7 6687 25 quality quality NN cord-005453-4057qib7 6687 26 test test NN cord-005453-4057qib7 6687 27 of of IN cord-005453-4057qib7 6687 28 the the DT cord-005453-4057qib7 6687 29 frozen frozen JJ cord-005453-4057qib7 6687 30 UC UC NNP cord-005453-4057qib7 6687 31 . . . cord-005453-4057qib7 6688 1 Then then RB cord-005453-4057qib7 6688 2 we -PRON- PRP cord-005453-4057qib7 6688 3 initiated initiate VBD cord-005453-4057qib7 6688 4 to to TO cord-005453-4057qib7 6688 5 isolate isolate VB cord-005453-4057qib7 6688 6 master master NN cord-005453-4057qib7 6688 7 UC UC NNP cord-005453-4057qib7 6688 8 - - HYPH cord-005453-4057qib7 6688 9 MSCs msc NNS cord-005453-4057qib7 6688 10 from from IN cord-005453-4057qib7 6688 11 frozen frozen JJ cord-005453-4057qib7 6688 12 - - HYPH cord-005453-4057qib7 6688 13 thawed thaw VBN cord-005453-4057qib7 6688 14 UC UC NNP cord-005453-4057qib7 6688 15 by by IN cord-005453-4057qib7 6688 16 an an DT cord-005453-4057qib7 6688 17 improved improve VBN cord-005453-4057qib7 6688 18 explant explant NN cord-005453-4057qib7 6688 19 method method NN cord-005453-4057qib7 6688 20 , , , cord-005453-4057qib7 6688 21 which which WDT cord-005453-4057qib7 6688 22 was be VBD cord-005453-4057qib7 6688 23 passed pass VBN cord-005453-4057qib7 6688 24 for for IN cord-005453-4057qib7 6688 25 quality quality NN cord-005453-4057qib7 6688 26 test test NN cord-005453-4057qib7 6688 27 . . . cord-005453-4057qib7 6689 1 The the DT cord-005453-4057qib7 6689 2 master master NN cord-005453-4057qib7 6689 3 UC UC NNP cord-005453-4057qib7 6689 4 - - HYPH cord-005453-4057qib7 6689 5 MSCs MSCs NNP cord-005453-4057qib7 6689 6 were be VBD cord-005453-4057qib7 6689 7 cryopreserved cryopreserve VBN cord-005453-4057qib7 6689 8 once once RB cord-005453-4057qib7 6689 9 and and CC cord-005453-4057qib7 6689 10 thawed thaw VBN cord-005453-4057qib7 6689 11 and and CC cord-005453-4057qib7 6689 12 expanded expand VBN cord-005453-4057qib7 6689 13 until until IN cord-005453-4057qib7 6689 14 P4 P4 NNP cord-005453-4057qib7 6689 15 . . . cord-005453-4057qib7 6690 1 Product product NN cord-005453-4057qib7 6690 2 cells cell NNS cord-005453-4057qib7 6690 3 were be VBD cord-005453-4057qib7 6690 4 cryopreserved cryopreserve VBN cord-005453-4057qib7 6690 5 in in IN cord-005453-4057qib7 6690 6 original original JJ cord-005453-4057qib7 6690 7 serum serum NN cord-005453-4057qib7 6690 8 - - HYPH cord-005453-4057qib7 6690 9 free free JJ cord-005453-4057qib7 6690 10 cryoprotectant cryoprotectant NN cord-005453-4057qib7 6690 11 DBA dba NN cord-005453-4057qib7 6690 12 - - HYPH cord-005453-4057qib7 6690 13 D d NN cord-005453-4057qib7 6690 14 solution solution NN cord-005453-4057qib7 6690 15 . . . cord-005453-4057qib7 6691 1 Mixed mixed JJ cord-005453-4057qib7 6691 2 lymphocyte lymphocyte NN cord-005453-4057qib7 6691 3 reaction reaction NN cord-005453-4057qib7 6692 1 ( ( -LRB- cord-005453-4057qib7 6692 2 MLR MLR NNP cord-005453-4057qib7 6692 3 ) ) -RRB- cord-005453-4057qib7 6692 4 assay assay NN cord-005453-4057qib7 6692 5 co co NN cord-005453-4057qib7 6692 6 - - JJ cord-005453-4057qib7 6692 7 cultured cultured JJ cord-005453-4057qib7 6692 8 with with IN cord-005453-4057qib7 6692 9 UC UC NNP cord-005453-4057qib7 6692 10 - - HYPH cord-005453-4057qib7 6692 11 MSCs MSCs NNP cord-005453-4057qib7 6692 12 was be VBD cord-005453-4057qib7 6692 13 carried carry VBN cord-005453-4057qib7 6692 14 out out RP cord-005453-4057qib7 6692 15 using use VBG cord-005453-4057qib7 6692 16 responder responder NN cord-005453-4057qib7 6692 17 mononuclear mononuclear NN cord-005453-4057qib7 6692 18 cells cell NNS cord-005453-4057qib7 6692 19 ( ( -LRB- cord-005453-4057qib7 6692 20 MNC MNC NNP cord-005453-4057qib7 6692 21 ) ) -RRB- cord-005453-4057qib7 6692 22 stained stain VBN cord-005453-4057qib7 6692 23 with with IN cord-005453-4057qib7 6692 24 CFSE CFSE NNP cord-005453-4057qib7 6692 25 , , , cord-005453-4057qib7 6692 26 and and CC cord-005453-4057qib7 6692 27 proliferation proliferation NN cord-005453-4057qib7 6692 28 and and CC cord-005453-4057qib7 6692 29 cytokine cytokine JJ cord-005453-4057qib7 6692 30 secretion secretion NN cord-005453-4057qib7 6692 31 were be VBD cord-005453-4057qib7 6692 32 analyzed analyze VBN cord-005453-4057qib7 6692 33 by by IN cord-005453-4057qib7 6692 34 flowcytometry flowcytometry NN cord-005453-4057qib7 6692 35 . . . cord-005453-4057qib7 6693 1 Results result NNS cord-005453-4057qib7 6693 2 : : : cord-005453-4057qib7 6694 1 UC UC NNP cord-005453-4057qib7 6694 2 - - HYPH cord-005453-4057qib7 6694 3 MSC MSC NNP cord-005453-4057qib7 6694 4 cultured culture VBN cord-005453-4057qib7 6694 5 showed show VBD cord-005453-4057qib7 6694 6 significantly significantly RB cord-005453-4057qib7 6694 7 higher high JJR cord-005453-4057qib7 6694 8 proliferation proliferation NN cord-005453-4057qib7 6694 9 ability ability NN cord-005453-4057qib7 6694 10 compared compare VBN cord-005453-4057qib7 6694 11 with with IN cord-005453-4057qib7 6694 12 those those DT cord-005453-4057qib7 6694 13 from from IN cord-005453-4057qib7 6694 14 bone bone NN cord-005453-4057qib7 6694 15 marrow marrow NN cord-005453-4057qib7 6694 16 - - HYPH cord-005453-4057qib7 6694 17 derived derive VBN cord-005453-4057qib7 6694 18 MSCs mscs NN cord-005453-4057qib7 6694 19 , , , cord-005453-4057qib7 6694 20 and and CC cord-005453-4057qib7 6694 21 positive positive JJ cord-005453-4057qib7 6694 22 for for IN cord-005453-4057qib7 6694 23 CD105 CD105 NNP cord-005453-4057qib7 6694 24 , , , cord-005453-4057qib7 6694 25 CD73 CD73 NNP cord-005453-4057qib7 6694 26 , , , cord-005453-4057qib7 6694 27 CD90 CD90 NNP cord-005453-4057qib7 6694 28 , , , cord-005453-4057qib7 6694 29 and and CC cord-005453-4057qib7 6694 30 negative negative JJ cord-005453-4057qib7 6694 31 for for IN cord-005453-4057qib7 6694 32 CD45 CD45 NNP cord-005453-4057qib7 6694 33 , , , cord-005453-4057qib7 6694 34 HLA HLA NNP cord-005453-4057qib7 6694 35 - - HYPH cord-005453-4057qib7 6694 36 DR DR NNP cord-005453-4057qib7 6694 37 . . . cord-005453-4057qib7 6695 1 CD80 CD80 NNP cord-005453-4057qib7 6695 2 , , , cord-005453-4057qib7 6695 3 and and CC cord-005453-4057qib7 6695 4 CD86 CD86 NNP cord-005453-4057qib7 6695 5 were be VBD cord-005453-4057qib7 6695 6 negative negative JJ cord-005453-4057qib7 6695 7 even even RB cord-005453-4057qib7 6695 8 in in IN cord-005453-4057qib7 6695 9 the the DT cord-005453-4057qib7 6695 10 high high JJ cord-005453-4057qib7 6695 11 concentration concentration NN cord-005453-4057qib7 6695 12 of of IN cord-005453-4057qib7 6695 13 IFN IFN NNP cord-005453-4057qib7 6695 14 - - HYPH cord-005453-4057qib7 6695 15 γ γ NNP cord-005453-4057qib7 6695 16 , , , cord-005453-4057qib7 6695 17 while while IN cord-005453-4057qib7 6695 18 BM BM NNP cord-005453-4057qib7 6695 19 - - HYPH cord-005453-4057qib7 6695 20 MSCs MSCs NNP cord-005453-4057qib7 6695 21 became become VBD cord-005453-4057qib7 6695 22 positive positive JJ cord-005453-4057qib7 6695 23 for for IN cord-005453-4057qib7 6695 24 HLA HLA NNP cord-005453-4057qib7 6695 25 - - HYPH cord-005453-4057qib7 6695 26 DR DR NNP cord-005453-4057qib7 6695 27 . . . cord-005453-4057qib7 6696 1 PD PD NNP cord-005453-4057qib7 6696 2 - - HYPH cord-005453-4057qib7 6696 3 L2 L2 NNP cord-005453-4057qib7 6696 4 was be VBD cord-005453-4057qib7 6696 5 constitutively constitutively RB cord-005453-4057qib7 6696 6 expressed express VBN cord-005453-4057qib7 6696 7 in in IN cord-005453-4057qib7 6696 8 UC UC NNP cord-005453-4057qib7 6696 9 - - HYPH cord-005453-4057qib7 6696 10 MSC MSC NNP cord-005453-4057qib7 6696 11 , , , cord-005453-4057qib7 6696 12 while while IN cord-005453-4057qib7 6696 13 PD PD NNP cord-005453-4057qib7 6696 14 - - HYPH cord-005453-4057qib7 6696 15 L1 L1 NNP cord-005453-4057qib7 6696 16 was be VBD cord-005453-4057qib7 6696 17 induced induce VBN cord-005453-4057qib7 6696 18 by by IN cord-005453-4057qib7 6696 19 the the DT cord-005453-4057qib7 6696 20 addition addition NN cord-005453-4057qib7 6696 21 of of IN cord-005453-4057qib7 6696 22 IFN IFN NNP cord-005453-4057qib7 6696 23 - - HYPH cord-005453-4057qib7 6696 24 γ γ NNP cord-005453-4057qib7 6696 25 . . . cord-005453-4057qib7 6697 1 In in IN cord-005453-4057qib7 6697 2 MLR MLR NNP cord-005453-4057qib7 6697 3 , , , cord-005453-4057qib7 6697 4 responder responder NN cord-005453-4057qib7 6697 5 T t NN cord-005453-4057qib7 6697 6 cell cell NN cord-005453-4057qib7 6697 7 proliferation proliferation NN cord-005453-4057qib7 6697 8 triggered trigger VBN cord-005453-4057qib7 6697 9 by by IN cord-005453-4057qib7 6697 10 allogeneic allogeneic NN cord-005453-4057qib7 6697 11 dendritic dendritic JJ cord-005453-4057qib7 6697 12 cells cell NNS cord-005453-4057qib7 6697 13 was be VBD cord-005453-4057qib7 6697 14 inhibited inhibit VBN cord-005453-4057qib7 6697 15 efficiently efficiently RB cord-005453-4057qib7 6697 16 by by IN cord-005453-4057qib7 6697 17 3rd 3rd NNP cord-005453-4057qib7 6697 18 party party NNP cord-005453-4057qib7 6697 19 derived derive VBD cord-005453-4057qib7 6697 20 UC UC NNP cord-005453-4057qib7 6697 21 - - HYPH cord-005453-4057qib7 6697 22 MSCs MSCs NNP cord-005453-4057qib7 6697 23 , , , cord-005453-4057qib7 6697 24 in in IN cord-005453-4057qib7 6697 25 which which WDT cord-005453-4057qib7 6697 26 was be VBD cord-005453-4057qib7 6697 27 induced induce VBN cord-005453-4057qib7 6697 28 IDO IDO NNP cord-005453-4057qib7 6697 29 , , , cord-005453-4057qib7 6697 30 PGE2 PGE2 NNP cord-005453-4057qib7 6697 31 , , , cord-005453-4057qib7 6697 32 HGF HGF NNP cord-005453-4057qib7 6697 33 , , , cord-005453-4057qib7 6697 34 and and CC cord-005453-4057qib7 6697 35 TGF TGF NNP cord-005453-4057qib7 6697 36 - - HYPH cord-005453-4057qib7 6697 37 β β NNP cord-005453-4057qib7 6697 38 analyzed analyze VBN cord-005453-4057qib7 6697 39 by by IN cord-005453-4057qib7 6697 40 RT RT NNP cord-005453-4057qib7 6697 41 - - HYPH cord-005453-4057qib7 6697 42 PCR PCR NNP cord-005453-4057qib7 6697 43 , , , cord-005453-4057qib7 6697 44 and and CC cord-005453-4057qib7 6697 45 inhibited inhibit VBN cord-005453-4057qib7 6697 46 IFN IFN NNP cord-005453-4057qib7 6697 47 - - HYPH cord-005453-4057qib7 6697 48 γ γ NNP cord-005453-4057qib7 6697 49 and and CC cord-005453-4057qib7 6697 50 TNF TNF NNP cord-005453-4057qib7 6697 51 - - HYPH cord-005453-4057qib7 6697 52 α α NN cord-005453-4057qib7 6697 53 in in IN cord-005453-4057qib7 6697 54 the the DT cord-005453-4057qib7 6697 55 supernatant supernatant NN cord-005453-4057qib7 6697 56 by by IN cord-005453-4057qib7 6697 57 cytokine cytokine JJ cord-005453-4057qib7 6697 58 beads bead NNS cord-005453-4057qib7 6697 59 array array NN cord-005453-4057qib7 6697 60 . . . cord-005453-4057qib7 6698 1 UC UC NNP cord-005453-4057qib7 6698 2 - - HYPH cord-005453-4057qib7 6698 3 MSCs MSCs NNP cord-005453-4057qib7 6698 4 migrated migrate VBD cord-005453-4057qib7 6698 5 toward toward IN cord-005453-4057qib7 6698 6 the the DT cord-005453-4057qib7 6698 7 TNF TNF NNP cord-005453-4057qib7 6698 8 - - HYPH cord-005453-4057qib7 6698 9 α α NNP cord-005453-4057qib7 6698 10 treated treat VBN cord-005453-4057qib7 6698 11 MNC MNC NNP cord-005453-4057qib7 6698 12 and and CC cord-005453-4057qib7 6698 13 increased increase VBN cord-005453-4057qib7 6698 14 regulatory regulatory JJ cord-005453-4057qib7 6698 15 T t NN cord-005453-4057qib7 6698 16 cells cell NNS cord-005453-4057qib7 6698 17 incidence incidence NN cord-005453-4057qib7 6698 18 in in IN cord-005453-4057qib7 6698 19 peripheral peripheral JJ cord-005453-4057qib7 6698 20 mononuclear mononuclear JJ cord-005453-4057qib7 6698 21 cells cell NNS cord-005453-4057qib7 6698 22 by by IN cord-005453-4057qib7 6698 23 the the DT cord-005453-4057qib7 6698 24 coculture coculture NN cord-005453-4057qib7 6698 25 . . . cord-005453-4057qib7 6699 1 Conclusions conclusion NNS cord-005453-4057qib7 6699 2 : : : cord-005453-4057qib7 6700 1 These these DT cord-005453-4057qib7 6700 2 results result NNS cord-005453-4057qib7 6700 3 demonstrated demonstrate VBD cord-005453-4057qib7 6700 4 that that IN cord-005453-4057qib7 6700 5 cryopreserved cryopreserved JJ cord-005453-4057qib7 6700 6 UC UC NNP cord-005453-4057qib7 6700 7 are be VBP cord-005453-4057qib7 6700 8 feasible feasible JJ cord-005453-4057qib7 6700 9 and and CC cord-005453-4057qib7 6700 10 efficient efficient JJ cord-005453-4057qib7 6700 11 source source NN cord-005453-4057qib7 6700 12 of of IN cord-005453-4057qib7 6700 13 MSCs mscs NN cord-005453-4057qib7 6700 14 and and CC cord-005453-4057qib7 6700 15 frozen frozen NNS cord-005453-4057qib7 6700 16 - - HYPH cord-005453-4057qib7 6700 17 thawed thaw VBN cord-005453-4057qib7 6700 18 UC UC NNP cord-005453-4057qib7 6700 19 - - HYPH cord-005453-4057qib7 6700 20 MSCs MSCs NNP cord-005453-4057qib7 6700 21 have have VBP cord-005453-4057qib7 6700 22 high high JJ cord-005453-4057qib7 6700 23 anti anti JJ cord-005453-4057qib7 6700 24 - - JJ cord-005453-4057qib7 6700 25 inflammatory inflammatory JJ cord-005453-4057qib7 6700 26 Background background NN cord-005453-4057qib7 6700 27 : : : cord-005453-4057qib7 6700 28 A a DT cord-005453-4057qib7 6700 29 new new JJ cord-005453-4057qib7 6700 30 protocol protocol NN cord-005453-4057qib7 6700 31 is be VBZ cord-005453-4057qib7 6700 32 under under IN cord-005453-4057qib7 6700 33 development development NN cord-005453-4057qib7 6700 34 on on IN cord-005453-4057qib7 6700 35 the the DT cord-005453-4057qib7 6700 36 AMICUS AMICUS NNP cord-005453-4057qib7 6700 37 Separator Separator NNP cord-005453-4057qib7 6700 38 that that WDT cord-005453-4057qib7 6700 39 enables enable VBZ cord-005453-4057qib7 6700 40 the the DT cord-005453-4057qib7 6700 41 device device NN cord-005453-4057qib7 6700 42 to to TO cord-005453-4057qib7 6700 43 perform perform VB cord-005453-4057qib7 6700 44 ECP ECP NNP cord-005453-4057qib7 6700 45 procedures procedure NNS cord-005453-4057qib7 6700 46 . . . cord-005453-4057qib7 6701 1 The the DT cord-005453-4057qib7 6701 2 AMICUS AMICUS NNP cord-005453-4057qib7 6701 3 Separator Separator NNP cord-005453-4057qib7 6701 4 is be VBZ cord-005453-4057qib7 6701 5 used use VBN cord-005453-4057qib7 6701 6 with with IN cord-005453-4057qib7 6701 7 a a DT cord-005453-4057qib7 6701 8 photoactivation photoactivation NN cord-005453-4057qib7 6701 9 device device NN cord-005453-4057qib7 6701 10 , , , cord-005453-4057qib7 6701 11 disposable disposable JJ cord-005453-4057qib7 6701 12 kit kit NN cord-005453-4057qib7 6701 13 and and CC cord-005453-4057qib7 6701 14 8-MOP 8-mop CD cord-005453-4057qib7 6701 15 to to TO cord-005453-4057qib7 6701 16 provide provide VB cord-005453-4057qib7 6701 17 ECP ECP NNP cord-005453-4057qib7 6701 18 therapy therapy NN cord-005453-4057qib7 6701 19 in in IN cord-005453-4057qib7 6701 20 a a DT cord-005453-4057qib7 6701 21 closed closed JJ cord-005453-4057qib7 6701 22 system system NN cord-005453-4057qib7 6701 23 . . . cord-005453-4057qib7 6702 1 The the DT cord-005453-4057qib7 6702 2 objective objective NN cord-005453-4057qib7 6702 3 of of IN cord-005453-4057qib7 6702 4 this this DT cord-005453-4057qib7 6702 5 study study NN cord-005453-4057qib7 6702 6 was be VBD cord-005453-4057qib7 6702 7 to to TO cord-005453-4057qib7 6702 8 evaluate evaluate VB cord-005453-4057qib7 6702 9 the the DT cord-005453-4057qib7 6702 10 safety safety NN cord-005453-4057qib7 6702 11 and and CC cord-005453-4057qib7 6702 12 performance performance NN cord-005453-4057qib7 6702 13 of of IN cord-005453-4057qib7 6702 14 the the DT cord-005453-4057qib7 6702 15 investigational investigational JJ cord-005453-4057qib7 6702 16 AMICUS AMICUS NNP cord-005453-4057qib7 6702 17 ECP ECP NNP cord-005453-4057qib7 6702 18 System System NNP cord-005453-4057qib7 6702 19 in in IN cord-005453-4057qib7 6702 20 healthy healthy JJ cord-005453-4057qib7 6702 21 human human JJ cord-005453-4057qib7 6702 22 subjects subject NNS cord-005453-4057qib7 6702 23 . . . cord-005453-4057qib7 6703 1 Methods method NNS cord-005453-4057qib7 6703 2 : : : cord-005453-4057qib7 6704 1 An an DT cord-005453-4057qib7 6704 2 IRB IRB NNP cord-005453-4057qib7 6704 3 - - HYPH cord-005453-4057qib7 6704 4 approved approve VBN cord-005453-4057qib7 6704 5 written write VBN cord-005453-4057qib7 6704 6 informed informed JJ cord-005453-4057qib7 6704 7 consent consent NN cord-005453-4057qib7 6704 8 was be VBD cord-005453-4057qib7 6704 9 obtained obtain VBN cord-005453-4057qib7 6704 10 from from IN cord-005453-4057qib7 6704 11 17 17 CD cord-005453-4057qib7 6704 12 subjects subject NNS cord-005453-4057qib7 6704 13 ( ( -LRB- cord-005453-4057qib7 6704 14 12 12 CD cord-005453-4057qib7 6704 15 male male NN cord-005453-4057qib7 6704 16 , , , cord-005453-4057qib7 6704 17 5 5 CD cord-005453-4057qib7 6704 18 female female NN cord-005453-4057qib7 6704 19 ) ) -RRB- cord-005453-4057qib7 6704 20 . . . cord-005453-4057qib7 6705 1 The the DT cord-005453-4057qib7 6705 2 AMICUS AMICUS NNP cord-005453-4057qib7 6705 3 ECP ECP NNP cord-005453-4057qib7 6705 4 System System NNP cord-005453-4057qib7 6705 5 processed process VBD cord-005453-4057qib7 6705 6 either either CC cord-005453-4057qib7 6705 7 500 500 CD cord-005453-4057qib7 6705 8 , , , cord-005453-4057qib7 6705 9 2000 2000 CD cord-005453-4057qib7 6705 10 or or CC cord-005453-4057qib7 6705 11 4000 4000 CD cord-005453-4057qib7 6705 12 mL ml NN cord-005453-4057qib7 6705 13 whole whole JJ cord-005453-4057qib7 6705 14 blood blood NN cord-005453-4057qib7 6705 15 ( ( -LRB- cord-005453-4057qib7 6705 16 n n NN cord-005453-4057qib7 6705 17 ≥ ≥ CD cord-005453-4057qib7 6705 18 5 5 CD cord-005453-4057qib7 6705 19 per per IN cord-005453-4057qib7 6705 20 arm arm NN cord-005453-4057qib7 6705 21 ) ) -RRB- cord-005453-4057qib7 6705 22 using use VBG cord-005453-4057qib7 6705 23 double double JJ cord-005453-4057qib7 6705 24 - - HYPH cord-005453-4057qib7 6705 25 needle needle NN cord-005453-4057qib7 6705 26 access access NN cord-005453-4057qib7 6705 27 and and CC cord-005453-4057qib7 6705 28 ACD acd NN cord-005453-4057qib7 6705 29 - - HYPH cord-005453-4057qib7 6705 30 A a DT cord-005453-4057qib7 6705 31 anticoagulation anticoagulation NN cord-005453-4057qib7 6705 32 at at IN cord-005453-4057qib7 6705 33 a a DT cord-005453-4057qib7 6705 34 12:1 12:1 CD cord-005453-4057qib7 6705 35 WB WB NNP cord-005453-4057qib7 6705 36 : : : cord-005453-4057qib7 6705 37 AC ac NN cord-005453-4057qib7 6705 38 ratio ratio NN cord-005453-4057qib7 6705 39 . . . cord-005453-4057qib7 6706 1 After after IN cord-005453-4057qib7 6706 2 MNC MNC NNP cord-005453-4057qib7 6706 3 collection collection NN cord-005453-4057qib7 6706 4 was be VBD cord-005453-4057qib7 6706 5 completed complete VBN cord-005453-4057qib7 6706 6 , , , cord-005453-4057qib7 6706 7 the the DT cord-005453-4057qib7 6706 8 subject subject NN cord-005453-4057qib7 6706 9 was be VBD cord-005453-4057qib7 6706 10 disconnected disconnect VBN cord-005453-4057qib7 6706 11 from from IN cord-005453-4057qib7 6706 12 the the DT cord-005453-4057qib7 6706 13 device device NN cord-005453-4057qib7 6706 14 . . . cord-005453-4057qib7 6707 1 8-MOP 8-mop CD cord-005453-4057qib7 6708 1 ( ( -LRB- cord-005453-4057qib7 6708 2 3.4 3.4 CD cord-005453-4057qib7 6708 3 mL ml NN cord-005453-4057qib7 6708 4 , , , cord-005453-4057qib7 6708 5 20 20 CD cord-005453-4057qib7 6708 6 μg μg NN cord-005453-4057qib7 6708 7 / / SYM cord-005453-4057qib7 6708 8 mL mL NNP cord-005453-4057qib7 6708 9 ) ) -RRB- cord-005453-4057qib7 6708 10 was be VBD cord-005453-4057qib7 6708 11 injected inject VBN cord-005453-4057qib7 6708 12 directly directly RB cord-005453-4057qib7 6708 13 into into IN cord-005453-4057qib7 6708 14 the the DT cord-005453-4057qib7 6708 15 collected collect VBN cord-005453-4057qib7 6708 16 MNC MNC NNP cord-005453-4057qib7 6708 17 product product NN cord-005453-4057qib7 6708 18 and and CC cord-005453-4057qib7 6708 19 saline saline NN cord-005453-4057qib7 6708 20 ( ( -LRB- cord-005453-4057qib7 6708 21 approximately approximately RB cord-005453-4057qib7 6708 22 200 200 CD cord-005453-4057qib7 6708 23 mL ml NN cord-005453-4057qib7 6708 24 total total NN cord-005453-4057qib7 6708 25 ) ) -RRB- cord-005453-4057qib7 6708 26 , , , cord-005453-4057qib7 6708 27 which which WDT cord-005453-4057qib7 6708 28 was be VBD cord-005453-4057qib7 6708 29 photoactivated photoactivate VBN cord-005453-4057qib7 6708 30 with with IN cord-005453-4057qib7 6708 31 1 1 CD cord-005453-4057qib7 6708 32 - - SYM cord-005453-4057qib7 6708 33 2 2 CD cord-005453-4057qib7 6708 34 J J NNP cord-005453-4057qib7 6708 35 / / SYM cord-005453-4057qib7 6708 36 cm cm NNP cord-005453-4057qib7 6708 37 2 2 CD cord-005453-4057qib7 6708 38 UVA UVA NNP cord-005453-4057qib7 6708 39 light light NN cord-005453-4057qib7 6708 40 . . . cord-005453-4057qib7 6709 1 Post post JJ cord-005453-4057qib7 6709 2 photoactivation photoactivation NN cord-005453-4057qib7 6709 3 , , , cord-005453-4057qib7 6709 4 the the DT cord-005453-4057qib7 6709 5 AMICUS AMICUS NNP cord-005453-4057qib7 6709 6 Separator Separator NNP cord-005453-4057qib7 6709 7 reinfused reinfuse VBD cord-005453-4057qib7 6709 8 the the DT cord-005453-4057qib7 6709 9 treated treat VBN cord-005453-4057qib7 6709 10 MNCs mnc NNS cord-005453-4057qib7 6709 11 into into IN cord-005453-4057qib7 6709 12 a a DT cord-005453-4057qib7 6709 13 transfer transfer NN cord-005453-4057qib7 6709 14 pack pack NN cord-005453-4057qib7 6709 15 . . . cord-005453-4057qib7 6710 1 Subject subject JJ cord-005453-4057qib7 6710 2 laboratory laboratory NN cord-005453-4057qib7 6710 3 and and CC cord-005453-4057qib7 6710 4 safety safety NN cord-005453-4057qib7 6710 5 parameters parameter NNS cord-005453-4057qib7 6710 6 were be VBD cord-005453-4057qib7 6710 7 evaluated evaluate VBN cord-005453-4057qib7 6710 8 ; ; : cord-005453-4057qib7 6710 9 in in FW cord-005453-4057qib7 6710 10 vitro vitro FW cord-005453-4057qib7 6710 11 evaluations evaluation NNS cord-005453-4057qib7 6710 12 were be VBD cord-005453-4057qib7 6710 13 performed perform VBN cord-005453-4057qib7 6710 14 on on IN cord-005453-4057qib7 6710 15 subject subject JJ cord-005453-4057qib7 6710 16 whole whole JJ cord-005453-4057qib7 6710 17 blood blood NN cord-005453-4057qib7 6710 18 , , , cord-005453-4057qib7 6710 19 collected collect VBN cord-005453-4057qib7 6710 20 MNCs mnc NNS cord-005453-4057qib7 6710 21 , , , cord-005453-4057qib7 6710 22 treated treat VBN cord-005453-4057qib7 6710 23 MNCs mnc NNS cord-005453-4057qib7 6710 24 , , , cord-005453-4057qib7 6710 25 and and CC cord-005453-4057qib7 6710 26 reinfused reinfuse VBD cord-005453-4057qib7 6710 27 cells cell NNS cord-005453-4057qib7 6710 28 . . . cord-005453-4057qib7 6711 1 Lymphocyte lymphocyte NN cord-005453-4057qib7 6711 2 and and CC cord-005453-4057qib7 6711 3 monocyte monocyte NNP cord-005453-4057qib7 6711 4 analysis analysis NN cord-005453-4057qib7 6711 5 were be VBD cord-005453-4057qib7 6711 6 performed perform VBN cord-005453-4057qib7 6711 7 on on IN cord-005453-4057qib7 6711 8 samples sample NNS cord-005453-4057qib7 6711 9 purified purify VBN cord-005453-4057qib7 6711 10 using use VBG cord-005453-4057qib7 6711 11 density density NN cord-005453-4057qib7 6711 12 gradient gradient NN cord-005453-4057qib7 6711 13 separation separation NN cord-005453-4057qib7 6711 14 and and CC cord-005453-4057qib7 6711 15 cultured culture VBN cord-005453-4057qib7 6711 16 for for IN cord-005453-4057qib7 6711 17 up up IN cord-005453-4057qib7 6711 18 to to TO cord-005453-4057qib7 6711 19 3 3 CD cord-005453-4057qib7 6711 20 days day NNS cord-005453-4057qib7 6711 21 post post NN cord-005453-4057qib7 6711 22 treatment treatment NN cord-005453-4057qib7 6711 23 . . . cord-005453-4057qib7 6712 1 Results result NNS cord-005453-4057qib7 6712 2 : : : cord-005453-4057qib7 6713 1 In in IN cord-005453-4057qib7 6713 2 17 17 CD cord-005453-4057qib7 6713 3 procedures procedure NNS cord-005453-4057qib7 6713 4 , , , cord-005453-4057qib7 6713 5 median median JJ cord-005453-4057qib7 6713 6 ( ( -LRB- cord-005453-4057qib7 6713 7 range range NN cord-005453-4057qib7 6713 8 ) ) -RRB- cord-005453-4057qib7 6713 9 WB WB NNP cord-005453-4057qib7 6713 10 processed process VBN cord-005453-4057qib7 6713 11 was be VBD cord-005453-4057qib7 6713 12 2016.0 2016.0 CD cord-005453-4057qib7 6714 1 ( ( -LRB- cord-005453-4057qib7 6714 2 509 509 CD cord-005453-4057qib7 6714 3 -4024 -4024 JJS cord-005453-4057qib7 6714 4 ) ) -RRB- cord-005453-4057qib7 6714 5 mL ml NN cord-005453-4057qib7 6714 6 using use VBG cord-005453-4057qib7 6714 7 172.0 172.0 CD cord-005453-4057qib7 6715 1 ( ( -LRB- cord-005453-4057qib7 6715 2 51 51 CD cord-005453-4057qib7 6715 3 -333 -333 NN cord-005453-4057qib7 6715 4 ) ) -RRB- cord-005453-4057qib7 6715 5 mL mL NNP cord-005453-4057qib7 6715 6 of of IN cord-005453-4057qib7 6715 7 ACD ACD NNP cord-005453-4057qib7 6715 8 - - HYPH cord-005453-4057qib7 6715 9 A. A. NNP cord-005453-4057qib7 6715 10 Procedure Procedure NNP cord-005453-4057qib7 6715 11 time time NN cord-005453-4057qib7 6715 12 was be VBD cord-005453-4057qib7 6715 13 93.0 93.0 CD cord-005453-4057qib7 6715 14 ( ( -LRB- cord-005453-4057qib7 6715 15 66 66 CD cord-005453-4057qib7 6715 16 -119 -119 NN cord-005453-4057qib7 6715 17 ) ) -RRB- cord-005453-4057qib7 6715 18 minutes minute NNS cord-005453-4057qib7 6715 19 , , , cord-005453-4057qib7 6715 20 including include VBG cord-005453-4057qib7 6715 21 photoactivation photoactivation NN cord-005453-4057qib7 6715 22 . . . cord-005453-4057qib7 6716 1 No no DT cord-005453-4057qib7 6716 2 adverse adverse JJ cord-005453-4057qib7 6716 3 events event NNS cord-005453-4057qib7 6716 4 were be VBD cord-005453-4057qib7 6716 5 reported report VBN cord-005453-4057qib7 6716 6 . . . cord-005453-4057qib7 6717 1 Subjects subject NNS cord-005453-4057qib7 6717 2 ' ' POS cord-005453-4057qib7 6717 3 vital vital JJ cord-005453-4057qib7 6717 4 signs sign NNS cord-005453-4057qib7 6717 5 and and CC cord-005453-4057qib7 6717 6 hematology hematology NN cord-005453-4057qib7 6717 7 values value NNS cord-005453-4057qib7 6717 8 were be VBD cord-005453-4057qib7 6717 9 unremarkable unremarkable JJ cord-005453-4057qib7 6717 10 and and CC cord-005453-4057qib7 6717 11 within within IN cord-005453-4057qib7 6717 12 expected expect VBN cord-005453-4057qib7 6717 13 values value NNS cord-005453-4057qib7 6717 14 . . . cord-005453-4057qib7 6718 1 The the DT cord-005453-4057qib7 6718 2 WBC WBC NNP cord-005453-4057qib7 6718 3 count count NN cord-005453-4057qib7 6718 4 of of IN cord-005453-4057qib7 6718 5 the the DT cord-005453-4057qib7 6718 6 collected collect VBN cord-005453-4057qib7 6718 7 MNCs mnc NNS cord-005453-4057qib7 6718 8 was be VBD cord-005453-4057qib7 6718 9 13.50 13.50 CD cord-005453-4057qib7 6718 10 ( ( -LRB- cord-005453-4057qib7 6718 11 3.3 3.3 CD cord-005453-4057qib7 6718 12 -30 -30 NN cord-005453-4057qib7 6718 13 . . . cord-005453-4057qib7 6718 14 2 2 LS cord-005453-4057qib7 6718 15 ) ) -RRB- cord-005453-4057qib7 6718 16 x10 x10 CD cord-005453-4057qib7 6718 17 3 3 CD cord-005453-4057qib7 6718 18 /μL /μl CD cord-005453-4057qib7 6718 19 , , , cord-005453-4057qib7 6718 20 comprised comprise VBN cord-005453-4057qib7 6718 21 of of IN cord-005453-4057qib7 6718 22 77.10 77.10 CD cord-005453-4057qib7 6718 23 ( ( -LRB- cord-005453-4057qib7 6718 24 47.9 47.9 CD cord-005453-4057qib7 6718 25 -87.0 -87.0 NFP cord-005453-4057qib7 6718 26 ) ) -RRB- cord-005453-4057qib7 6718 27 % % NN cord-005453-4057qib7 6718 28 lymphocytes lymphocyte NNS cord-005453-4057qib7 6718 29 , , , cord-005453-4057qib7 6718 30 15.50 15.50 CD cord-005453-4057qib7 6718 31 ( ( -LRB- cord-005453-4057qib7 6718 32 7.0 7.0 CD cord-005453-4057qib7 6718 33 -36.8 -36.8 CD cord-005453-4057qib7 6718 34 ) ) -RRB- cord-005453-4057qib7 6718 35 % % NN cord-005453-4057qib7 6718 36 monocytes monocyte NNS cord-005453-4057qib7 6718 37 and and CC cord-005453-4057qib7 6718 38 5.70 5.70 CD cord-005453-4057qib7 6718 39 ( ( -LRB- cord-005453-4057qib7 6718 40 2.9 2.9 CD cord-005453-4057qib7 6718 41 -25.5 -25.5 CD cord-005453-4057qib7 6718 42 ) ) -RRB- cord-005453-4057qib7 6718 43 % % NN cord-005453-4057qib7 6718 44 granulocytes granulocyte NNS cord-005453-4057qib7 6718 45 and and CC cord-005453-4057qib7 6718 46 platelet platelet NN cord-005453-4057qib7 6718 47 count count NN cord-005453-4057qib7 6718 48 was be VBD cord-005453-4057qib7 6718 49 94.0 94.0 CD cord-005453-4057qib7 6718 50 ( ( -LRB- cord-005453-4057qib7 6718 51 70 70 CD cord-005453-4057qib7 6718 52 -169 -169 NNS cord-005453-4057qib7 6718 53 ) ) -RRB- cord-005453-4057qib7 6719 1 Background background NN cord-005453-4057qib7 6719 2 : : : cord-005453-4057qib7 6719 3 Transfusion transfusion NN cord-005453-4057qib7 6719 4 of of IN cord-005453-4057qib7 6719 5 white white JJ cord-005453-4057qib7 6719 6 blood blood NN cord-005453-4057qib7 6719 7 cells cell NNS cord-005453-4057qib7 6719 8 ( ( -LRB- cord-005453-4057qib7 6719 9 WBC WBC NNP cord-005453-4057qib7 6719 10 ) ) -RRB- cord-005453-4057qib7 6719 11 causes cause VBZ cord-005453-4057qib7 6719 12 a a DT cord-005453-4057qib7 6719 13 number number NN cord-005453-4057qib7 6719 14 of of IN cord-005453-4057qib7 6719 15 transfusion transfusion NN cord-005453-4057qib7 6719 16 reactions reaction NNS cord-005453-4057qib7 6719 17 and and CC cord-005453-4057qib7 6719 18 complications complication NNS cord-005453-4057qib7 6719 19 , , , cord-005453-4057qib7 6719 20 for for IN cord-005453-4057qib7 6719 21 example example NN cord-005453-4057qib7 6719 22 transfusion transfusion NN cord-005453-4057qib7 6719 23 - - HYPH cord-005453-4057qib7 6719 24 associated associate VBN cord-005453-4057qib7 6719 25 graft graft NN cord-005453-4057qib7 6719 26 versus versus IN cord-005453-4057qib7 6719 27 host host NN cord-005453-4057qib7 6719 28 disease disease NN cord-005453-4057qib7 6719 29 ( ( -LRB- cord-005453-4057qib7 6719 30 taGVHT taGVHT NNP cord-005453-4057qib7 6719 31 ) ) -RRB- cord-005453-4057qib7 6719 32 , , , cord-005453-4057qib7 6719 33 which which WDT cord-005453-4057qib7 6719 34 still still RB cord-005453-4057qib7 6719 35 does do VBZ cord-005453-4057qib7 6719 36 not not RB cord-005453-4057qib7 6719 37 have have VB cord-005453-4057qib7 6719 38 effective effective JJ cord-005453-4057qib7 6719 39 treatment treatment NN cord-005453-4057qib7 6719 40 and and CC cord-005453-4057qib7 6719 41 is be VBZ cord-005453-4057qib7 6719 42 a a DT cord-005453-4057qib7 6719 43 fatal fatal JJ cord-005453-4057qib7 6719 44 complication complication NN cord-005453-4057qib7 6719 45 of of IN cord-005453-4057qib7 6719 46 transfusions transfusion NNS cord-005453-4057qib7 6719 47 . . . cord-005453-4057qib7 6720 1 The the DT cord-005453-4057qib7 6720 2 only only JJ cord-005453-4057qib7 6720 3 effective effective JJ cord-005453-4057qib7 6720 4 method method NN cord-005453-4057qib7 6720 5 of of IN cord-005453-4057qib7 6720 6 preventing prevent VBG cord-005453-4057qib7 6720 7 taGVHT taGVHT NNP cord-005453-4057qib7 6720 8 is be VBZ cord-005453-4057qib7 6720 9 irradiation irradiation NN cord-005453-4057qib7 6720 10 of of IN cord-005453-4057qib7 6720 11 blood blood NN cord-005453-4057qib7 6720 12 components component NNS cord-005453-4057qib7 6720 13 with with IN cord-005453-4057qib7 6720 14 ionizing ionize VBG cord-005453-4057qib7 6720 15 radiation radiation NN cord-005453-4057qib7 6720 16 ( ( -LRB- cord-005453-4057qib7 6720 17 X x NN cord-005453-4057qib7 6720 18 - - NN cord-005453-4057qib7 6720 19 ray ray NN cord-005453-4057qib7 6720 20 or or CC cord-005453-4057qib7 6720 21 gamma gamma NN cord-005453-4057qib7 6720 22 radiation radiation NN cord-005453-4057qib7 6720 23 ) ) -RRB- cord-005453-4057qib7 6720 24 . . . cord-005453-4057qib7 6721 1 But but CC cord-005453-4057qib7 6721 2 the the DT cord-005453-4057qib7 6721 3 use use NN cord-005453-4057qib7 6721 4 of of IN cord-005453-4057qib7 6721 5 ionizing ionize VBG cord-005453-4057qib7 6721 6 radiation radiation NN cord-005453-4057qib7 6721 7 sources source NNS cord-005453-4057qib7 6721 8 has have VBZ cord-005453-4057qib7 6721 9 a a DT cord-005453-4057qib7 6721 10 number number NN cord-005453-4057qib7 6721 11 of of IN cord-005453-4057qib7 6721 12 technical technical JJ cord-005453-4057qib7 6721 13 and and CC cord-005453-4057qib7 6721 14 material material JJ cord-005453-4057qib7 6721 15 difficulties difficulty NNS cord-005453-4057qib7 6721 16 . . . cord-005453-4057qib7 6722 1 The the DT cord-005453-4057qib7 6722 2 emergence emergence NN cord-005453-4057qib7 6722 3 of of IN cord-005453-4057qib7 6722 4 pathogen pathogen NN cord-005453-4057qib7 6722 5 reduction reduction NN cord-005453-4057qib7 6722 6 technologies technology NNS cord-005453-4057qib7 6722 7 ( ( -LRB- cord-005453-4057qib7 6722 8 PRT PRT NNP cord-005453-4057qib7 6722 9 ) ) -RRB- cord-005453-4057qib7 6722 10 in in IN cord-005453-4057qib7 6722 11 blood blood NN cord-005453-4057qib7 6722 12 components component NNS cord-005453-4057qib7 6722 13 targeted target VBN cord-005453-4057qib7 6722 14 by by IN cord-005453-4057qib7 6722 15 nucleic nucleic JJ cord-005453-4057qib7 6722 16 acids acid NNS cord-005453-4057qib7 6722 17 has have VBZ cord-005453-4057qib7 6722 18 opened open VBN cord-005453-4057qib7 6722 19 the the DT cord-005453-4057qib7 6722 20 possibility possibility NN cord-005453-4057qib7 6722 21 of of IN cord-005453-4057qib7 6722 22 using use VBG cord-005453-4057qib7 6722 23 these these DT cord-005453-4057qib7 6722 24 technologies technology NNS cord-005453-4057qib7 6722 25 as as IN cord-005453-4057qib7 6722 26 an an DT cord-005453-4057qib7 6722 27 alternative alternative NN cord-005453-4057qib7 6722 28 to to IN cord-005453-4057qib7 6722 29 irradiating irradiate VBG cord-005453-4057qib7 6722 30 of of IN cord-005453-4057qib7 6722 31 blood blood NN cord-005453-4057qib7 6722 32 components component NNS cord-005453-4057qib7 6722 33 . . . cord-005453-4057qib7 6723 1 Several several JJ cord-005453-4057qib7 6723 2 PRT PRT NNP cord-005453-4057qib7 6723 3 demonstrated demonstrate VBD cord-005453-4057qib7 6723 4 effective effective JJ cord-005453-4057qib7 6723 5 inactivation inactivation NN cord-005453-4057qib7 6723 6 of of IN cord-005453-4057qib7 6723 7 WBC WBC NNP cord-005453-4057qib7 6723 8 in in IN cord-005453-4057qib7 6723 9 platelet platelet NN cord-005453-4057qib7 6723 10 concentrates concentrate NNS cord-005453-4057qib7 6723 11 and and CC cord-005453-4057qib7 6723 12 blood blood NN cord-005453-4057qib7 6723 13 plasma plasma NN cord-005453-4057qib7 6723 14 . . . cord-005453-4057qib7 6724 1 So so RB cord-005453-4057qib7 6724 2 , , , cord-005453-4057qib7 6724 3 determination determination NN cord-005453-4057qib7 6724 4 of of IN cord-005453-4057qib7 6724 5 the the DT cord-005453-4057qib7 6724 6 influence influence NN cord-005453-4057qib7 6724 7 of of IN cord-005453-4057qib7 6724 8 PRT PRT NNP cord-005453-4057qib7 6724 9 based base VBN cord-005453-4057qib7 6724 10 on on IN cord-005453-4057qib7 6724 11 the the DT cord-005453-4057qib7 6724 12 combined combined JJ cord-005453-4057qib7 6724 13 effect effect NN cord-005453-4057qib7 6724 14 of of IN cord-005453-4057qib7 6724 15 riboflavin riboflavin NN cord-005453-4057qib7 6724 16 ( ( -LRB- cord-005453-4057qib7 6724 17 RF rf NN cord-005453-4057qib7 6724 18 ) ) -RRB- cord-005453-4057qib7 6724 19 and and CC cord-005453-4057qib7 6724 20 ultraviolet ultraviolet NN cord-005453-4057qib7 6724 21 ( ( -LRB- cord-005453-4057qib7 6724 22 UV uv NN cord-005453-4057qib7 6724 23 ) ) -RRB- cord-005453-4057qib7 6724 24 on on IN cord-005453-4057qib7 6724 25 the the DT cord-005453-4057qib7 6724 26 viability viability NN cord-005453-4057qib7 6724 27 and and CC cord-005453-4057qib7 6724 28 proliferating proliferate VBG cord-005453-4057qib7 6724 29 potential potential NN cord-005453-4057qib7 6724 30 of of IN cord-005453-4057qib7 6724 31 lymphocytes lymphocyte NNS cord-005453-4057qib7 6724 32 in in IN cord-005453-4057qib7 6724 33 whole whole JJ cord-005453-4057qib7 6724 34 blood blood NN cord-005453-4057qib7 6724 35 is be VBZ cord-005453-4057qib7 6724 36 important important JJ cord-005453-4057qib7 6724 37 . . . cord-005453-4057qib7 6725 1 Methods method NNS cord-005453-4057qib7 6725 2 : : : cord-005453-4057qib7 6725 3 Samples sample NNS cord-005453-4057qib7 6725 4 of of IN cord-005453-4057qib7 6725 5 whole whole JJ cord-005453-4057qib7 6725 6 blood blood NN cord-005453-4057qib7 6725 7 were be VBD cord-005453-4057qib7 6725 8 obtained obtain VBN cord-005453-4057qib7 6725 9 in in IN cord-005453-4057qib7 6725 10 35 35 CD cord-005453-4057qib7 6725 11 healthy healthy JJ cord-005453-4057qib7 6725 12 volunteers volunteer NNS cord-005453-4057qib7 6725 13 . . . cord-005453-4057qib7 6726 1 Each each DT cord-005453-4057qib7 6726 2 sample sample NN cord-005453-4057qib7 6726 3 was be VBD cord-005453-4057qib7 6726 4 divided divide VBN cord-005453-4057qib7 6726 5 into into IN cord-005453-4057qib7 6726 6 three three CD cord-005453-4057qib7 6726 7 unequal unequal JJ cord-005453-4057qib7 6726 8 parts part NNS cord-005453-4057qib7 6726 9 : : : cord-005453-4057qib7 6726 10 untreated untreated JJ cord-005453-4057qib7 6726 11 control control NN cord-005453-4057qib7 6726 12 , , , cord-005453-4057qib7 6726 13 gamma gamma NN cord-005453-4057qib7 6726 14 irradiated irradiate VBD cord-005453-4057qib7 6726 15 , , , cord-005453-4057qib7 6726 16 and and CC cord-005453-4057qib7 6726 17 treated treat VBN cord-005453-4057qib7 6726 18 by by IN cord-005453-4057qib7 6726 19 RF RF NNP cord-005453-4057qib7 6726 20 and and CC cord-005453-4057qib7 6726 21 UV UV NNP cord-005453-4057qib7 6726 22 PRT PRT NNP cord-005453-4057qib7 6726 23 ( ( -LRB- cord-005453-4057qib7 6726 24 Mirasol Mirasol NNP cord-005453-4057qib7 6726 25 , , , cord-005453-4057qib7 6726 26 Terumo Terumo NNP cord-005453-4057qib7 6726 27 BCT BCT NNP cord-005453-4057qib7 6726 28 Inc. Inc. NNP cord-005453-4057qib7 6726 29 ) ) -RRB- cord-005453-4057qib7 6726 30 . . . cord-005453-4057qib7 6727 1 Mononuclear Mononuclear NNP cord-005453-4057qib7 6727 2 cells cell NNS cord-005453-4057qib7 6727 3 ( ( -LRB- cord-005453-4057qib7 6727 4 MNC MNC NNP cord-005453-4057qib7 6727 5 ) ) -RRB- cord-005453-4057qib7 6727 6 were be VBD cord-005453-4057qib7 6727 7 CFSE CFSE NNP cord-005453-4057qib7 6727 8 stained stain VBN cord-005453-4057qib7 6727 9 , , , cord-005453-4057qib7 6727 10 viability viability NN cord-005453-4057qib7 6727 11 and and CC cord-005453-4057qib7 6727 12 proliferating proliferate VBG cord-005453-4057qib7 6727 13 activity activity NN cord-005453-4057qib7 6727 14 were be VBD cord-005453-4057qib7 6727 15 tested test VBN cord-005453-4057qib7 6727 16 at at IN cord-005453-4057qib7 6727 17 intervals interval NNS cord-005453-4057qib7 6727 18 of of IN cord-005453-4057qib7 6727 19 24 24 CD cord-005453-4057qib7 6727 20 hours hour NNS cord-005453-4057qib7 6727 21 for for IN cord-005453-4057qib7 6727 22 3 3 CD cord-005453-4057qib7 6727 23 consecutive consecutive JJ cord-005453-4057qib7 6727 24 days day NNS cord-005453-4057qib7 6727 25 by by IN cord-005453-4057qib7 6727 26 flow flow NN cord-005453-4057qib7 6727 27 cytometry cytometry NN cord-005453-4057qib7 6727 28 . . . cord-005453-4057qib7 6728 1 Statistical statistical JJ cord-005453-4057qib7 6728 2 analysis analysis NN cord-005453-4057qib7 6728 3 was be VBD cord-005453-4057qib7 6728 4 performed perform VBN cord-005453-4057qib7 6728 5 with with IN cord-005453-4057qib7 6728 6 XLStat XLStat NNP cord-005453-4057qib7 6728 7 7.0 7.0 CD cord-005453-4057qib7 6728 8 . . . cord-005453-4057qib7 6729 1 Levels level NNS cord-005453-4057qib7 6729 2 of of IN cord-005453-4057qib7 6729 3 significance significance NN cord-005453-4057qib7 6729 4 were be VBD cord-005453-4057qib7 6729 5 calculated calculate VBN cord-005453-4057qib7 6729 6 by by IN cord-005453-4057qib7 6729 7 Mann Mann NNP cord-005453-4057qib7 6729 8 - - HYPH cord-005453-4057qib7 6729 9 Whitney Whitney NNP cord-005453-4057qib7 6729 10 test test NN cord-005453-4057qib7 6729 11 , , , cord-005453-4057qib7 6729 12 expressed express VBD cord-005453-4057qib7 6729 13 as as IN cord-005453-4057qib7 6729 14 P p NN cord-005453-4057qib7 6729 15 - - HYPH cord-005453-4057qib7 6729 16 values value NNS cord-005453-4057qib7 6729 17 ( ( -LRB- cord-005453-4057qib7 6729 18 P p NN cord-005453-4057qib7 6729 19 < < XX cord-005453-4057qib7 6729 20 0,05 0,05 NN cord-005453-4057qib7 6729 21 ) ) -RRB- cord-005453-4057qib7 6729 22 . . . cord-005453-4057qib7 6730 1 Results result NNS cord-005453-4057qib7 6730 2 : : : cord-005453-4057qib7 6731 1 The the DT cord-005453-4057qib7 6731 2 median median JJ cord-005453-4057qib7 6731 3 viability viability NN cord-005453-4057qib7 6731 4 of of IN cord-005453-4057qib7 6731 5 MNC MNC NNP cord-005453-4057qib7 6731 6 after after IN cord-005453-4057qib7 6731 7 application application NN cord-005453-4057qib7 6731 8 of of IN cord-005453-4057qib7 6731 9 both both DT cord-005453-4057qib7 6731 10 methods method NNS cord-005453-4057qib7 6731 11 of of IN cord-005453-4057qib7 6731 12 treatment treatment NN cord-005453-4057qib7 6731 13 was be VBD cord-005453-4057qib7 6731 14 over over IN cord-005453-4057qib7 6731 15 85,0 85,0 CD cord-005453-4057qib7 6731 16 % % NN cord-005453-4057qib7 6731 17 on on IN cord-005453-4057qib7 6731 18 day day NN cord-005453-4057qib7 6731 19 0 0 CD cord-005453-4057qib7 6731 20 and and CC cord-005453-4057qib7 6731 21 decreased decrease VBD cord-005453-4057qib7 6731 22 to to IN cord-005453-4057qib7 6731 23 day day NN cord-005453-4057qib7 6731 24 3 3 CD cord-005453-4057qib7 6731 25 -median -median JJ cord-005453-4057qib7 6731 26 percentage percentage NN cord-005453-4057qib7 6731 27 of of IN cord-005453-4057qib7 6731 28 viable viable JJ cord-005453-4057qib7 6731 29 MNC MNC NNP cord-005453-4057qib7 6731 30 were be VBD cord-005453-4057qib7 6731 31 84,0 84,0 CD cord-005453-4057qib7 6731 32 % % NN cord-005453-4057qib7 6731 33 ( ( -LRB- cord-005453-4057qib7 6731 34 control control NNP cord-005453-4057qib7 6731 35 group group NN cord-005453-4057qib7 6731 36 ) ) -RRB- cord-005453-4057qib7 6731 37 , , , cord-005453-4057qib7 6731 38 69,0 69,0 CD cord-005453-4057qib7 6731 39 % % NN cord-005453-4057qib7 6731 40 ( ( -LRB- cord-005453-4057qib7 6731 41 after after IN cord-005453-4057qib7 6731 42 gamma gamma NN cord-005453-4057qib7 6731 43 irradiation irradiation NN cord-005453-4057qib7 6731 44 ) ) -RRB- cord-005453-4057qib7 6731 45 and and CC cord-005453-4057qib7 6731 46 63,0 63,0 CD cord-005453-4057qib7 6731 47 % % NN cord-005453-4057qib7 6731 48 ( ( -LRB- cord-005453-4057qib7 6731 49 RF rf NN cord-005453-4057qib7 6731 50 / / SYM cord-005453-4057qib7 6731 51 UV UV NNP cord-005453-4057qib7 6731 52 PRT PRT NNP cord-005453-4057qib7 6731 53 ) ) -RRB- cord-005453-4057qib7 6731 54 . . . cord-005453-4057qib7 6732 1 The the DT cord-005453-4057qib7 6732 2 median median NN cord-005453-4057qib7 6732 3 of of IN cord-005453-4057qib7 6732 4 spontaneous spontaneous JJ cord-005453-4057qib7 6732 5 proliferative proliferative JJ cord-005453-4057qib7 6732 6 activity activity NN cord-005453-4057qib7 6732 7 on on IN cord-005453-4057qib7 6732 8 day day NN cord-005453-4057qib7 6732 9 3 3 CD cord-005453-4057qib7 6732 10 of of IN cord-005453-4057qib7 6732 11 untreated untreated JJ cord-005453-4057qib7 6732 12 and and CC cord-005453-4057qib7 6732 13 gamma gamma NN cord-005453-4057qib7 6732 14 irradiated irradiate VBD cord-005453-4057qib7 6733 1 MNC MNC NNP cord-005453-4057qib7 6733 2 did do VBD cord-005453-4057qib7 6733 3 not not RB cord-005453-4057qib7 6733 4 differ differ VB cord-005453-4057qib7 6733 5 ( ( -LRB- cord-005453-4057qib7 6733 6 1,8 1,8 CD cord-005453-4057qib7 6733 7 % % NN cord-005453-4057qib7 6733 8 and and CC cord-005453-4057qib7 6733 9 2,1 2,1 CD cord-005453-4057qib7 6733 10 % % NN cord-005453-4057qib7 6733 11 respectively respectively RB cord-005453-4057qib7 6733 12 , , , cord-005453-4057qib7 6733 13 p p NN cord-005453-4057qib7 6733 14 < < XX cord-005453-4057qib7 6733 15 0,05 0,05 NNP cord-005453-4057qib7 6733 16 ) ) -RRB- cord-005453-4057qib7 6733 17 . . . cord-005453-4057qib7 6734 1 Phytohemaglutenin Phytohemaglutenin NNP cord-005453-4057qib7 6734 2 ( ( -LRB- cord-005453-4057qib7 6734 3 PHA PHA NNP cord-005453-4057qib7 6734 4 ) ) -RRB- cord-005453-4057qib7 6734 5 induced induce VBD cord-005453-4057qib7 6734 6 proliferation proliferation NN cord-005453-4057qib7 6734 7 on on IN cord-005453-4057qib7 6734 8 day day NN cord-005453-4057qib7 6734 9 3 3 CD cord-005453-4057qib7 6734 10 in in IN cord-005453-4057qib7 6734 11 gamma gamma NN cord-005453-4057qib7 6734 12 - - HYPH cord-005453-4057qib7 6734 13 irradiated irradiate VBN cord-005453-4057qib7 6734 14 samples sample NNS cord-005453-4057qib7 6734 15 was be VBD cord-005453-4057qib7 6734 16 significantly significantly RB cord-005453-4057qib7 6734 17 lower low JJR cord-005453-4057qib7 6734 18 in in IN cord-005453-4057qib7 6734 19 comparison comparison NN cord-005453-4057qib7 6734 20 with with IN cord-005453-4057qib7 6734 21 control control NN cord-005453-4057qib7 6734 22 group group NN cord-005453-4057qib7 6734 23 ( ( -LRB- cord-005453-4057qib7 6734 24 4,0 4,0 CD cord-005453-4057qib7 6734 25 % % NN cord-005453-4057qib7 6734 26 and and CC cord-005453-4057qib7 6734 27 45,0 45,0 CD cord-005453-4057qib7 6734 28 % % NN cord-005453-4057qib7 6734 29 respectively respectively RB cord-005453-4057qib7 6734 30 , , , cord-005453-4057qib7 6734 31 p p NN cord-005453-4057qib7 6734 32 < < XX cord-005453-4057qib7 6734 33 0,01 0,01 NN cord-005453-4057qib7 6734 34 ) ) -RRB- cord-005453-4057qib7 6734 35 . . . cord-005453-4057qib7 6735 1 In in IN cord-005453-4057qib7 6735 2 samples sample NNS cord-005453-4057qib7 6735 3 treated treat VBN cord-005453-4057qib7 6735 4 with with IN cord-005453-4057qib7 6735 5 RF RF NNP cord-005453-4057qib7 6735 6 / / SYM cord-005453-4057qib7 6735 7 UV uv NN cord-005453-4057qib7 6735 8 , , , cord-005453-4057qib7 6735 9 spontaneous spontaneous JJ cord-005453-4057qib7 6735 10 and and CC cord-005453-4057qib7 6735 11 stimulated stimulate VBN cord-005453-4057qib7 6735 12 proliferating proliferate VBG cord-005453-4057qib7 6735 13 cells cell NNS cord-005453-4057qib7 6735 14 was be VBD cord-005453-4057qib7 6735 15 not not RB cord-005453-4057qib7 6735 16 detected detect VBN cord-005453-4057qib7 6735 17 . . . cord-005453-4057qib7 6736 1 Median median JJ cord-005453-4057qib7 6736 2 percentage percentage NN cord-005453-4057qib7 6736 3 of of IN cord-005453-4057qib7 6736 4 proliferating proliferate VBG cord-005453-4057qib7 6736 5 MNC MNC NNP cord-005453-4057qib7 6736 6 was be VBD cord-005453-4057qib7 6737 1 less less JJR cord-005453-4057qib7 6737 2 than than IN cord-005453-4057qib7 6737 3 0,2 0,2 CD cord-005453-4057qib7 6737 4 % % NN cord-005453-4057qib7 6737 5 . . . cord-005453-4057qib7 6738 1 The the DT cord-005453-4057qib7 6738 2 use use NN cord-005453-4057qib7 6738 3 of of IN cord-005453-4057qib7 6738 4 this this DT cord-005453-4057qib7 6738 5 PRT PRT NNP cord-005453-4057qib7 6738 6 on on IN cord-005453-4057qib7 6738 7 whole whole JJ cord-005453-4057qib7 6738 8 blood blood NN cord-005453-4057qib7 6738 9 , , , cord-005453-4057qib7 6738 10 as as RB cord-005453-4057qib7 6738 11 well well RB cord-005453-4057qib7 6738 12 as as IN cord-005453-4057qib7 6738 13 gamma gamma NN cord-005453-4057qib7 6738 14 irradiation irradiation NN cord-005453-4057qib7 6738 15 , , , cord-005453-4057qib7 6738 16 significantly significantly RB cord-005453-4057qib7 6738 17 reduces reduce VBZ cord-005453-4057qib7 6738 18 the the DT cord-005453-4057qib7 6738 19 viability viability NN cord-005453-4057qib7 6738 20 of of IN cord-005453-4057qib7 6738 21 lymphocytes lymphocyte NNS cord-005453-4057qib7 6738 22 during during IN cord-005453-4057qib7 6738 23 storage storage NN cord-005453-4057qib7 6738 24 for for IN cord-005453-4057qib7 6738 25 3 3 CD cord-005453-4057qib7 6738 26 days day NNS cord-005453-4057qib7 6738 27 . . . cord-005453-4057qib7 6739 1 Conclusions conclusion NNS cord-005453-4057qib7 6739 2 : : : cord-005453-4057qib7 6740 1 Inactivation Inactivation NNP cord-005453-4057qib7 6740 2 of of IN cord-005453-4057qib7 6740 3 WBC WBC NNP cord-005453-4057qib7 6740 4 using use VBG cord-005453-4057qib7 6740 5 RF RF NNP cord-005453-4057qib7 6740 6 / / SYM cord-005453-4057qib7 6740 7 UV UV NNP cord-005453-4057qib7 6740 8 PRT PRT NNP cord-005453-4057qib7 6740 9 is be VBZ cord-005453-4057qib7 6740 10 a a DT cord-005453-4057qib7 6740 11 useful useful JJ cord-005453-4057qib7 6740 12 and and CC cord-005453-4057qib7 6740 13 very very RB cord-005453-4057qib7 6740 14 necessary necessary JJ cord-005453-4057qib7 6740 15 bonus bonus NN cord-005453-4057qib7 6740 16 for for IN cord-005453-4057qib7 6740 17 a a DT cord-005453-4057qib7 6740 18 number number NN cord-005453-4057qib7 6740 19 of of IN cord-005453-4057qib7 6740 20 reasons reason NNS cord-005453-4057qib7 6740 21 . . . cord-005453-4057qib7 6741 1 In in IN cord-005453-4057qib7 6741 2 one one CD cord-005453-4057qib7 6741 3 procedure procedure NN cord-005453-4057qib7 6741 4 two two CD cord-005453-4057qib7 6741 5 effects effect NNS cord-005453-4057qib7 6741 6 are be VBP cord-005453-4057qib7 6741 7 achieved achieve VBN cord-005453-4057qib7 6741 8 : : : cord-005453-4057qib7 6741 9 infectious infectious JJ cord-005453-4057qib7 6741 10 and and CC cord-005453-4057qib7 6741 11 immunological immunological JJ cord-005453-4057qib7 6741 12 safety safety NN cord-005453-4057qib7 6741 13 . . . cord-005453-4057qib7 6742 1 The the DT cord-005453-4057qib7 6742 2 use use NN cord-005453-4057qib7 6742 3 of of IN cord-005453-4057qib7 6742 4 PRT PRT NNP cord-005453-4057qib7 6742 5 on on IN cord-005453-4057qib7 6742 6 whole whole JJ cord-005453-4057qib7 6742 7 blood blood NN cord-005453-4057qib7 6742 8 gives give VBZ cord-005453-4057qib7 6742 9 the the DT cord-005453-4057qib7 6742 10 potential potential NN cord-005453-4057qib7 6742 11 for for IN cord-005453-4057qib7 6742 12 obtaining obtain VBG cord-005453-4057qib7 6742 13 pathogen pathogen NN cord-005453-4057qib7 6742 14 - - HYPH cord-005453-4057qib7 6742 15 reduced reduce VBN cord-005453-4057qib7 6742 16 and and CC cord-005453-4057qib7 6742 17 immunological immunological JJ cord-005453-4057qib7 6742 18 safety safety NN cord-005453-4057qib7 6742 19 components component NNS cord-005453-4057qib7 6742 20 of of IN cord-005453-4057qib7 6742 21 blood blood NN cord-005453-4057qib7 6742 22 , , , cord-005453-4057qib7 6742 23 which which WDT cord-005453-4057qib7 6742 24 reduces reduce VBZ cord-005453-4057qib7 6742 25 their -PRON- PRP$ cord-005453-4057qib7 6742 26 material material NN cord-005453-4057qib7 6742 27 cost cost NN cord-005453-4057qib7 6742 28 and and CC cord-005453-4057qib7 6742 29 staff staff NN cord-005453-4057qib7 6742 30 loading loading NN cord-005453-4057qib7 6742 31 . . . cord-005453-4057qib7 6743 1 The the DT cord-005453-4057qib7 6743 2 use use NN cord-005453-4057qib7 6743 3 of of IN cord-005453-4057qib7 6743 4 RF rf NN cord-005453-4057qib7 6743 5 / / SYM cord-005453-4057qib7 6743 6 UV uv NN cord-005453-4057qib7 6743 7 system system NN cord-005453-4057qib7 6743 8 does do VBZ cord-005453-4057qib7 6743 9 not not RB cord-005453-4057qib7 6743 10 have have VB cord-005453-4057qib7 6743 11 such such JJ cord-005453-4057qib7 6743 12 complex complex JJ cord-005453-4057qib7 6743 13 security security NN cord-005453-4057qib7 6743 14 requirements requirement NNS cord-005453-4057qib7 6743 15 and and CC cord-005453-4057qib7 6743 16 difficulties difficulty NNS cord-005453-4057qib7 6743 17 in in IN cord-005453-4057qib7 6743 18 servicing service VBG cord-005453-4057qib7 6743 19 as as IN cord-005453-4057qib7 6743 20 the the DT cord-005453-4057qib7 6743 21 use use NN cord-005453-4057qib7 6743 22 of of IN cord-005453-4057qib7 6743 23 sources source NNS cord-005453-4057qib7 6743 24 of of IN cord-005453-4057qib7 6743 25 ionizing ionize VBG cord-005453-4057qib7 6743 26 radiation radiation NN cord-005453-4057qib7 6743 27 . . . cord-005453-4057qib7 6744 1 The the DT cord-005453-4057qib7 6744 2 results result NNS cord-005453-4057qib7 6744 3 demonstrate demonstrate VBP cord-005453-4057qib7 6744 4 a a DT cord-005453-4057qib7 6744 5 promising promising JJ cord-005453-4057qib7 6744 6 potential potential NN cord-005453-4057qib7 6744 7 for for IN cord-005453-4057qib7 6744 8 using use VBG cord-005453-4057qib7 6744 9 this this DT cord-005453-4057qib7 6744 10 technology technology NN cord-005453-4057qib7 6744 11 as as IN cord-005453-4057qib7 6744 12 an an DT cord-005453-4057qib7 6744 13 alternative alternative NN cord-005453-4057qib7 6744 14 to to IN cord-005453-4057qib7 6744 15 irradiation irradiation NN cord-005453-4057qib7 6744 16 Disclosure disclosure NN cord-005453-4057qib7 6744 17 : : : cord-005453-4057qib7 6745 1 Nothing nothing NN cord-005453-4057qib7 6745 2 to to TO cord-005453-4057qib7 6745 3 declare declare VB cord-005453-4057qib7 6745 4 P308 P308 NNP cord-005453-4057qib7 6745 5 Influence influence NN cord-005453-4057qib7 6745 6 of of IN cord-005453-4057qib7 6745 7 patients´serum patients´serum NNP cord-005453-4057qib7 6745 8 after after IN cord-005453-4057qib7 6745 9 allogeneic allogeneic NN cord-005453-4057qib7 6745 10 stem stem NN cord-005453-4057qib7 6745 11 cell cell NN cord-005453-4057qib7 6745 12 transplantation transplantation NN cord-005453-4057qib7 6745 13 on on IN cord-005453-4057qib7 6745 14 T t NN cord-005453-4057qib7 6745 15 cell cell NN cord-005453-4057qib7 6745 16 proliferation proliferation NN cord-005453-4057qib7 6745 17 and and CC cord-005453-4057qib7 6745 18 TREG TREG NNP cord-005453-4057qib7 6745 19 function function NN cord-005453-4057qib7 6745 20 Background background NN cord-005453-4057qib7 6745 21 : : : cord-005453-4057qib7 6746 1 Acute acute JJ cord-005453-4057qib7 6746 2 or or CC cord-005453-4057qib7 6746 3 chronic chronic JJ cord-005453-4057qib7 6746 4 graft graft NN cord-005453-4057qib7 6746 5 versus versus IN cord-005453-4057qib7 6746 6 host host NN cord-005453-4057qib7 6746 7 disease disease NN cord-005453-4057qib7 6746 8 ( ( -LRB- cord-005453-4057qib7 6746 9 a/ a/ NNP cord-005453-4057qib7 6746 10 cGVHD cGVHD NNP cord-005453-4057qib7 6746 11 ) ) -RRB- cord-005453-4057qib7 6746 12 is be VBZ cord-005453-4057qib7 6746 13 one one CD cord-005453-4057qib7 6746 14 of of IN cord-005453-4057qib7 6746 15 the the DT cord-005453-4057qib7 6746 16 major major JJ cord-005453-4057qib7 6746 17 complications complication NNS cord-005453-4057qib7 6746 18 after after IN cord-005453-4057qib7 6746 19 allogeneic allogeneic JJ cord-005453-4057qib7 6746 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 6746 21 stem stem NN cord-005453-4057qib7 6746 22 cell cell NN cord-005453-4057qib7 6746 23 transplantation transplantation NN cord-005453-4057qib7 6746 24 ( ( -LRB- cord-005453-4057qib7 6746 25 aHSCT aHSCT NNP cord-005453-4057qib7 6746 26 ) ) -RRB- cord-005453-4057qib7 6746 27 . . . cord-005453-4057qib7 6747 1 Application application NN cord-005453-4057qib7 6747 2 of of IN cord-005453-4057qib7 6747 3 regulatory regulatory JJ cord-005453-4057qib7 6747 4 T t NN cord-005453-4057qib7 6747 5 cells cell NNS cord-005453-4057qib7 6747 6 ( ( -LRB- cord-005453-4057qib7 6747 7 Treg Treg NNP cord-005453-4057qib7 6747 8 ) ) -RRB- cord-005453-4057qib7 6747 9 as as IN cord-005453-4057qib7 6747 10 " " `` cord-005453-4057qib7 6747 11 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6747 12 DLI DLI NNP cord-005453-4057qib7 6747 13 " " '' cord-005453-4057qib7 6747 14 to to TO cord-005453-4057qib7 6747 15 prevent prevent VB cord-005453-4057qib7 6747 16 or or CC cord-005453-4057qib7 6747 17 treat treat VB cord-005453-4057qib7 6747 18 GVHD GVHD NNP cord-005453-4057qib7 6747 19 is be VBZ cord-005453-4057qib7 6747 20 investigated investigate VBN cord-005453-4057qib7 6747 21 in in IN cord-005453-4057qib7 6747 22 clinical clinical JJ cord-005453-4057qib7 6747 23 trials trial NNS cord-005453-4057qib7 6747 24 . . . cord-005453-4057qib7 6748 1 Here here RB cord-005453-4057qib7 6748 2 we -PRON- PRP cord-005453-4057qib7 6748 3 ask ask VBP cord-005453-4057qib7 6748 4 the the DT cord-005453-4057qib7 6748 5 question question NN cord-005453-4057qib7 6748 6 , , , cord-005453-4057qib7 6748 7 if if IN cord-005453-4057qib7 6748 8 there there EX cord-005453-4057qib7 6748 9 could could MD cord-005453-4057qib7 6748 10 be be VB cord-005453-4057qib7 6748 11 clinical clinical JJ cord-005453-4057qib7 6748 12 conditions condition NNS cord-005453-4057qib7 6748 13 ( ( -LRB- cord-005453-4057qib7 6748 14 e.g. e.g. IN cord-005453-4057qib7 6748 15 cytokines cytokine NNS cord-005453-4057qib7 6748 16 or or CC cord-005453-4057qib7 6748 17 drug drug NN cord-005453-4057qib7 6748 18 effects effect NNS cord-005453-4057qib7 6748 19 ) ) -RRB- cord-005453-4057qib7 6748 20 limiting limit VBG cord-005453-4057qib7 6748 21 the the DT cord-005453-4057qib7 6748 22 efficacy efficacy NN cord-005453-4057qib7 6748 23 of of IN cord-005453-4057qib7 6748 24 this this DT cord-005453-4057qib7 6748 25 approach approach NN cord-005453-4057qib7 6748 26 . . . cord-005453-4057qib7 6749 1 To to TO cord-005453-4057qib7 6749 2 face face VB cord-005453-4057qib7 6749 3 this this DT cord-005453-4057qib7 6749 4 problem problem NN cord-005453-4057qib7 6749 5 we -PRON- PRP cord-005453-4057qib7 6749 6 tested test VBD cord-005453-4057qib7 6749 7 the the DT cord-005453-4057qib7 6749 8 influence influence NN cord-005453-4057qib7 6749 9 of of IN cord-005453-4057qib7 6749 10 patients´serum patients´serum NNP cord-005453-4057qib7 6749 11 on on IN cord-005453-4057qib7 6749 12 T T NNP cord-005453-4057qib7 6749 13 cell cell NN cord-005453-4057qib7 6749 14 proliferation proliferation NN cord-005453-4057qib7 6749 15 and and CC cord-005453-4057qib7 6749 16 Treg Treg NNP cord-005453-4057qib7 6749 17 function function NN cord-005453-4057qib7 6749 18 . . . cord-005453-4057qib7 6750 1 Methods method NNS cord-005453-4057qib7 6750 2 : : : cord-005453-4057qib7 6750 3 Lymphocytes lymphocyte NNS cord-005453-4057qib7 6750 4 from from IN cord-005453-4057qib7 6750 5 healthy healthy JJ cord-005453-4057qib7 6750 6 donors donor NNS cord-005453-4057qib7 6750 7 were be VBD cord-005453-4057qib7 6750 8 incubated incubate VBN cord-005453-4057qib7 6750 9 with with IN cord-005453-4057qib7 6750 10 T T NNP cord-005453-4057qib7 6750 11 cell cell NN cord-005453-4057qib7 6750 12 medium medium NN cord-005453-4057qib7 6750 13 ( ( -LRB- cord-005453-4057qib7 6750 14 90 90 CD cord-005453-4057qib7 6750 15 % % NN cord-005453-4057qib7 6750 16 AIM aim NN cord-005453-4057qib7 6750 17 V v NN cord-005453-4057qib7 6750 18 + + CC cord-005453-4057qib7 6751 1 10 10 CD cord-005453-4057qib7 6751 2 % % NN cord-005453-4057qib7 6751 3 serum serum NN cord-005453-4057qib7 6751 4 + + CC cord-005453-4057qib7 6751 5 IL2 IL2 NNP cord-005453-4057qib7 6751 6 / / SYM cord-005453-4057qib7 6751 7 OKT3 OKT3 NNP cord-005453-4057qib7 6751 8 ) ) -RRB- cord-005453-4057qib7 6751 9 containing contain VBG cord-005453-4057qib7 6751 10 serum serum NN cord-005453-4057qib7 6751 11 from from IN cord-005453-4057qib7 6751 12 healthy healthy JJ cord-005453-4057qib7 6751 13 donors donor NNS cord-005453-4057qib7 6751 14 or or CC cord-005453-4057qib7 6751 15 serum serum NN cord-005453-4057qib7 6751 16 derived derive VBN cord-005453-4057qib7 6751 17 from from IN cord-005453-4057qib7 6751 18 patients patient NNS cord-005453-4057qib7 6751 19 after after IN cord-005453-4057qib7 6751 20 aHSCT ahsct NN cord-005453-4057qib7 6751 21 with with IN cord-005453-4057qib7 6751 22 or or CC cord-005453-4057qib7 6751 23 without without IN cord-005453-4057qib7 6751 24 GVHD GVHD NNP cord-005453-4057qib7 6751 25 ( ( -LRB- cord-005453-4057qib7 6751 26 n=10 n=10 NNP cord-005453-4057qib7 6751 27 ) ) -RRB- cord-005453-4057qib7 6751 28 . . . cord-005453-4057qib7 6752 1 Next next RB cord-005453-4057qib7 6752 2 we -PRON- PRP cord-005453-4057qib7 6752 3 evaluated evaluate VBD cord-005453-4057qib7 6752 4 the the DT cord-005453-4057qib7 6752 5 suppressive suppressive JJ cord-005453-4057qib7 6752 6 function function NN cord-005453-4057qib7 6752 7 of of IN cord-005453-4057qib7 6752 8 Treg Treg NNP cord-005453-4057qib7 6752 9 by by IN cord-005453-4057qib7 6752 10 performing perform VBG cord-005453-4057qib7 6752 11 Treg Treg NNP cord-005453-4057qib7 6752 12 suppression suppression NN cord-005453-4057qib7 6752 13 assays assay NNS cord-005453-4057qib7 6752 14 , , , cord-005453-4057qib7 6752 15 also also RB cord-005453-4057qib7 6752 16 comparing compare VBG cord-005453-4057qib7 6752 17 serum serum NN cord-005453-4057qib7 6752 18 from from IN cord-005453-4057qib7 6752 19 patients patient NNS cord-005453-4057qib7 6752 20 suffering suffer VBG cord-005453-4057qib7 6752 21 from from IN cord-005453-4057qib7 6752 22 GVHD GVHD NNP cord-005453-4057qib7 6752 23 versus versus IN cord-005453-4057qib7 6752 24 serum serum NN cord-005453-4057qib7 6752 25 obtained obtain VBN cord-005453-4057qib7 6752 26 from from IN cord-005453-4057qib7 6752 27 healthy healthy JJ cord-005453-4057qib7 6752 28 donors donor NNS cord-005453-4057qib7 6752 29 ( ( -LRB- cord-005453-4057qib7 6752 30 n=8 n=8 NN cord-005453-4057qib7 6752 31 ) ) -RRB- cord-005453-4057qib7 6752 32 . . . cord-005453-4057qib7 6753 1 Proliferation proliferation NN cord-005453-4057qib7 6753 2 of of IN cord-005453-4057qib7 6753 3 CFSE CFSE NNP cord-005453-4057qib7 6753 4 stained stain VBN cord-005453-4057qib7 6753 5 T t NN cord-005453-4057qib7 6753 6 cells cell NNS cord-005453-4057qib7 6753 7 was be VBD cord-005453-4057qib7 6753 8 measured measure VBN cord-005453-4057qib7 6753 9 after after IN cord-005453-4057qib7 6753 10 5 5 CD cord-005453-4057qib7 6753 11 days day NNS cord-005453-4057qib7 6753 12 . . . cord-005453-4057qib7 6754 1 To to TO cord-005453-4057qib7 6754 2 test test VB cord-005453-4057qib7 6754 3 the the DT cord-005453-4057qib7 6754 4 effect effect NN cord-005453-4057qib7 6754 5 of of IN cord-005453-4057qib7 6754 6 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6754 7 drugs drug NNS cord-005453-4057qib7 6754 8 on on IN cord-005453-4057qib7 6754 9 Treg Treg NNP cord-005453-4057qib7 6754 10 we -PRON- PRP cord-005453-4057qib7 6754 11 performed perform VBD cord-005453-4057qib7 6754 12 Treg Treg NNP cord-005453-4057qib7 6754 13 suppression suppression NN cord-005453-4057qib7 6754 14 assays assay NNS cord-005453-4057qib7 6754 15 after after IN cord-005453-4057qib7 6754 16 incubation incubation NN cord-005453-4057qib7 6754 17 of of IN cord-005453-4057qib7 6754 18 Treg Treg NNP cord-005453-4057qib7 6754 19 with with IN cord-005453-4057qib7 6754 20 Corticosteroids Corticosteroids NNPS cord-005453-4057qib7 6754 21 or or CC cord-005453-4057qib7 6754 22 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 6754 23 or or CC cord-005453-4057qib7 6754 24 the the DT cord-005453-4057qib7 6754 25 combination combination NN cord-005453-4057qib7 6754 26 of of IN cord-005453-4057qib7 6754 27 both both DT cord-005453-4057qib7 6754 28 drugs drug NNS cord-005453-4057qib7 6754 29 . . . cord-005453-4057qib7 6755 1 Results result NNS cord-005453-4057qib7 6755 2 : : : cord-005453-4057qib7 6756 1 Serum serum NN cord-005453-4057qib7 6756 2 of of IN cord-005453-4057qib7 6756 3 patients patient NNS cord-005453-4057qib7 6756 4 with with IN cord-005453-4057qib7 6756 5 acute acute JJ cord-005453-4057qib7 6756 6 or or CC cord-005453-4057qib7 6756 7 chronic chronic JJ cord-005453-4057qib7 6756 8 GVHD GVHD NNP cord-005453-4057qib7 6756 9 had have VBD cord-005453-4057qib7 6756 10 a a DT cord-005453-4057qib7 6756 11 negative negative JJ cord-005453-4057qib7 6756 12 effect effect NN cord-005453-4057qib7 6756 13 on on IN cord-005453-4057qib7 6756 14 T t NN cord-005453-4057qib7 6756 15 cell cell NN cord-005453-4057qib7 6756 16 proliferation proliferation NN cord-005453-4057qib7 6756 17 . . . cord-005453-4057qib7 6757 1 To to TO cord-005453-4057qib7 6757 2 avoid avoid VB cord-005453-4057qib7 6757 3 bias bias NN cord-005453-4057qib7 6757 4 tests test NNS cord-005453-4057qib7 6757 5 were be VBD cord-005453-4057qib7 6757 6 performed perform VBN cord-005453-4057qib7 6757 7 with with IN cord-005453-4057qib7 6757 8 samples sample NNS cord-005453-4057qib7 6757 9 from from IN cord-005453-4057qib7 6757 10 patients patient NNS cord-005453-4057qib7 6757 11 without without IN cord-005453-4057qib7 6757 12 or or CC cord-005453-4057qib7 6757 13 only only RB cord-005453-4057qib7 6757 14 with with IN cord-005453-4057qib7 6757 15 low low JJ cord-005453-4057qib7 6757 16 levels level NNS cord-005453-4057qib7 6757 17 of of IN cord-005453-4057qib7 6757 18 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6757 19 drugs drug NNS cord-005453-4057qib7 6757 20 . . . cord-005453-4057qib7 6758 1 Incubation incubation NN cord-005453-4057qib7 6758 2 with with IN cord-005453-4057qib7 6758 3 serum serum NN cord-005453-4057qib7 6758 4 of of IN cord-005453-4057qib7 6758 5 patients patient NNS cord-005453-4057qib7 6758 6 without without IN cord-005453-4057qib7 6758 7 GVHD GVHD NNP cord-005453-4057qib7 6758 8 or or CC cord-005453-4057qib7 6758 9 with with IN cord-005453-4057qib7 6758 10 serum serum NN cord-005453-4057qib7 6758 11 of of IN cord-005453-4057qib7 6758 12 healthy healthy JJ cord-005453-4057qib7 6758 13 individuals individual NNS cord-005453-4057qib7 6758 14 showed show VBD cord-005453-4057qib7 6758 15 no no DT cord-005453-4057qib7 6758 16 differences difference NNS cord-005453-4057qib7 6758 17 in in IN cord-005453-4057qib7 6758 18 T t NN cord-005453-4057qib7 6758 19 cell cell NN cord-005453-4057qib7 6758 20 proliferation proliferation NN cord-005453-4057qib7 6758 21 . . . cord-005453-4057qib7 6759 1 Treg Treg NNP cord-005453-4057qib7 6759 2 from from IN cord-005453-4057qib7 6759 3 healthy healthy JJ cord-005453-4057qib7 6759 4 donors donor NNS cord-005453-4057qib7 6759 5 showed show VBD cord-005453-4057qib7 6759 6 a a DT cord-005453-4057qib7 6759 7 stronger strong JJR cord-005453-4057qib7 6759 8 antiproliferative antiproliferative JJ cord-005453-4057qib7 6759 9 capacity capacity NN cord-005453-4057qib7 6759 10 when when WRB cord-005453-4057qib7 6759 11 incubated incubate VBN cord-005453-4057qib7 6759 12 with with IN cord-005453-4057qib7 6759 13 serum serum NN cord-005453-4057qib7 6759 14 derived derive VBN cord-005453-4057qib7 6759 15 from from IN cord-005453-4057qib7 6759 16 patients patient NNS cord-005453-4057qib7 6759 17 with with IN cord-005453-4057qib7 6759 18 GVHD GVHD NNP cord-005453-4057qib7 6759 19 . . . cord-005453-4057qib7 6760 1 Treg Treg NNP cord-005453-4057qib7 6760 2 previously previously RB cord-005453-4057qib7 6760 3 incubated incubate VBD cord-005453-4057qib7 6760 4 with with IN cord-005453-4057qib7 6760 5 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6760 6 drugs drug NNS cord-005453-4057qib7 6760 7 showed show VBD cord-005453-4057qib7 6760 8 no no DT cord-005453-4057qib7 6760 9 decreased decrease VBN cord-005453-4057qib7 6760 10 suppressive suppressive JJ cord-005453-4057qib7 6760 11 capacity capacity NN cord-005453-4057qib7 6760 12 . . . cord-005453-4057qib7 6761 1 Conclusions conclusion NNS cord-005453-4057qib7 6761 2 : : : cord-005453-4057qib7 6762 1 Components component NNS cord-005453-4057qib7 6762 2 of of IN cord-005453-4057qib7 6762 3 serum serum NN cord-005453-4057qib7 6762 4 from from IN cord-005453-4057qib7 6762 5 GVHD GVHD NNP cord-005453-4057qib7 6762 6 patients patient NNS cord-005453-4057qib7 6762 7 seem seem VBP cord-005453-4057qib7 6762 8 to to TO cord-005453-4057qib7 6762 9 have have VB cord-005453-4057qib7 6762 10 an an DT cord-005453-4057qib7 6762 11 antiproliferative antiproliferative JJ cord-005453-4057qib7 6762 12 effect effect NN cord-005453-4057qib7 6762 13 on on IN cord-005453-4057qib7 6762 14 T t NN cord-005453-4057qib7 6762 15 lymphocytes lymphocyte NNS cord-005453-4057qib7 6762 16 itself -PRON- PRP cord-005453-4057qib7 6762 17 . . . cord-005453-4057qib7 6763 1 This this DT cord-005453-4057qib7 6763 2 fact fact NN cord-005453-4057qib7 6763 3 might may MD cord-005453-4057qib7 6763 4 influence influence VB cord-005453-4057qib7 6763 5 the the DT cord-005453-4057qib7 6763 6 clinical clinical JJ cord-005453-4057qib7 6763 7 course course NN cord-005453-4057qib7 6763 8 of of IN cord-005453-4057qib7 6763 9 GVHD GVHD NNP cord-005453-4057qib7 6763 10 , , , cord-005453-4057qib7 6763 11 but but CC cord-005453-4057qib7 6763 12 should should MD cord-005453-4057qib7 6763 13 not not RB cord-005453-4057qib7 6763 14 be be VB cord-005453-4057qib7 6763 15 a a DT cord-005453-4057qib7 6763 16 limiting limit VBG cord-005453-4057qib7 6763 17 factor factor NN cord-005453-4057qib7 6763 18 for for IN cord-005453-4057qib7 6763 19 therapeutic therapeutic JJ cord-005453-4057qib7 6763 20 application application NN cord-005453-4057qib7 6763 21 of of IN cord-005453-4057qib7 6763 22 Treg Treg NNP cord-005453-4057qib7 6763 23 DLI DLI NNP cord-005453-4057qib7 6763 24 . . . cord-005453-4057qib7 6764 1 Even even RB cord-005453-4057qib7 6764 2 the the DT cord-005453-4057qib7 6764 3 systemic systemic JJ cord-005453-4057qib7 6764 4 treatment treatment NN cord-005453-4057qib7 6764 5 with with IN cord-005453-4057qib7 6764 6 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6764 7 drugs drug NNS cord-005453-4057qib7 6765 1 e.g. e.g. IN cord-005453-4057qib7 6765 2 corticosteroids corticosteroid NNS cord-005453-4057qib7 6765 3 or or CC cord-005453-4057qib7 6765 4 calcineurin calcineurin NN cord-005453-4057qib7 6765 5 - - HYPH cord-005453-4057qib7 6765 6 inhibitors inhibitor NNS cord-005453-4057qib7 6765 7 should should MD cord-005453-4057qib7 6765 8 not not RB cord-005453-4057qib7 6765 9 diminish diminish VB cord-005453-4057qib7 6765 10 the the DT cord-005453-4057qib7 6765 11 Treg Treg NNP cord-005453-4057qib7 6765 12 application application NN cord-005453-4057qib7 6765 13 . . . cord-005453-4057qib7 6766 1 In in IN cord-005453-4057qib7 6766 2 a a DT cord-005453-4057qib7 6766 3 next next JJ cord-005453-4057qib7 6766 4 step step NN cord-005453-4057qib7 6766 5 we -PRON- PRP cord-005453-4057qib7 6766 6 will will MD cord-005453-4057qib7 6766 7 analyze analyze VB cord-005453-4057qib7 6766 8 serum serum NN cord-005453-4057qib7 6766 9 components component NNS cord-005453-4057qib7 6766 10 responsible responsible JJ cord-005453-4057qib7 6766 11 for for IN cord-005453-4057qib7 6766 12 this this DT cord-005453-4057qib7 6766 13 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 6766 14 effect effect NN cord-005453-4057qib7 6766 15 with with IN cord-005453-4057qib7 6766 16 multi multi JJ cord-005453-4057qib7 6766 17 cytokine cytokine NN cord-005453-4057qib7 6766 18 assays assay NNS cord-005453-4057qib7 6766 19 and and CC cord-005453-4057qib7 6766 20 proteomic proteomic JJ cord-005453-4057qib7 6766 21 analysis analysis NN cord-005453-4057qib7 6766 22 . . . cord-005453-4057qib7 6767 1 The the DT cord-005453-4057qib7 6767 2 aim aim NN cord-005453-4057qib7 6767 3 of of IN cord-005453-4057qib7 6767 4 our -PRON- PRP$ cord-005453-4057qib7 6767 5 project project NN cord-005453-4057qib7 6767 6 is be VBZ cord-005453-4057qib7 6767 7 to to TO cord-005453-4057qib7 6767 8 develop develop VB cord-005453-4057qib7 6767 9 new new JJ cord-005453-4057qib7 6767 10 strategies strategy NNS cord-005453-4057qib7 6767 11 to to TO cord-005453-4057qib7 6767 12 avoid avoid VB cord-005453-4057qib7 6767 13 GVHD GVHD NNP cord-005453-4057qib7 6767 14 and and CC cord-005453-4057qib7 6767 15 to to TO cord-005453-4057qib7 6767 16 optimize optimize VB cord-005453-4057qib7 6767 17 clinical clinical JJ cord-005453-4057qib7 6767 18 settings setting NNS cord-005453-4057qib7 6767 19 for for IN cord-005453-4057qib7 6767 20 Treg Treg NNP cord-005453-4057qib7 6767 21 DLI DLI NNP cord-005453-4057qib7 6767 22 . . . cord-005453-4057qib7 6768 1 Disclosure disclosure NN cord-005453-4057qib7 6768 2 Background background NN cord-005453-4057qib7 6768 3 : : : cord-005453-4057qib7 6768 4 Hypercalcaemia Hypercalcaemia NNP cord-005453-4057qib7 6768 5 can can MD cord-005453-4057qib7 6768 6 be be VB cord-005453-4057qib7 6768 7 very very RB cord-005453-4057qib7 6768 8 severe severe JJ cord-005453-4057qib7 6768 9 following follow VBG cord-005453-4057qib7 6768 10 stem stem NN cord-005453-4057qib7 6768 11 cell cell NN cord-005453-4057qib7 6768 12 transplant transplant NN cord-005453-4057qib7 6768 13 ( ( -LRB- cord-005453-4057qib7 6768 14 SCT SCT NNP cord-005453-4057qib7 6768 15 ) ) -RRB- cord-005453-4057qib7 6768 16 in in IN cord-005453-4057qib7 6768 17 some some DT cord-005453-4057qib7 6768 18 osteopetrosis osteopetrosis NN cord-005453-4057qib7 6768 19 patients patient NNS cord-005453-4057qib7 6768 20 . . . cord-005453-4057qib7 6769 1 Denosumab Denosumab NNP cord-005453-4057qib7 6769 2 is be VBZ cord-005453-4057qib7 6769 3 a a DT cord-005453-4057qib7 6769 4 fully fully RB cord-005453-4057qib7 6769 5 human human JJ cord-005453-4057qib7 6769 6 monoclonal monoclonal JJ cord-005453-4057qib7 6769 7 antibody antibody NN cord-005453-4057qib7 6769 8 that that WDT cord-005453-4057qib7 6769 9 binds bind VBZ cord-005453-4057qib7 6769 10 the the DT cord-005453-4057qib7 6769 11 cytokine cytokine NN cord-005453-4057qib7 6769 12 RANKL RANKL NNP cord-005453-4057qib7 6769 13 ( ( -LRB- cord-005453-4057qib7 6769 14 receptor receptor NN cord-005453-4057qib7 6769 15 activator activator NN cord-005453-4057qib7 6769 16 of of IN cord-005453-4057qib7 6769 17 NFκB NFκB NNP cord-005453-4057qib7 6769 18 ligand ligand NN cord-005453-4057qib7 6769 19 ) ) -RRB- cord-005453-4057qib7 6769 20 , , , cord-005453-4057qib7 6769 21 an an DT cord-005453-4057qib7 6769 22 essential essential JJ cord-005453-4057qib7 6769 23 factor factor NN cord-005453-4057qib7 6769 24 initiating initiate VBG cord-005453-4057qib7 6769 25 bone bone NN cord-005453-4057qib7 6769 26 turnover turnover NN cord-005453-4057qib7 6769 27 . . . cord-005453-4057qib7 6770 1 RANKL RANKL NNP cord-005453-4057qib7 6770 2 inhibition inhibition NN cord-005453-4057qib7 6770 3 blocks block VBZ cord-005453-4057qib7 6770 4 osteoclast osteoclast NN cord-005453-4057qib7 6770 5 maturation maturation NN cord-005453-4057qib7 6770 6 , , , cord-005453-4057qib7 6770 7 function function NN cord-005453-4057qib7 6770 8 and and CC cord-005453-4057qib7 6770 9 survival survival NN cord-005453-4057qib7 6770 10 , , , cord-005453-4057qib7 6770 11 thus thus RB cord-005453-4057qib7 6770 12 reducing reduce VBG cord-005453-4057qib7 6770 13 bone bone NN cord-005453-4057qib7 6770 14 resorption resorption NN cord-005453-4057qib7 6770 15 . . . cord-005453-4057qib7 6771 1 We -PRON- PRP cord-005453-4057qib7 6771 2 describe describe VBP cord-005453-4057qib7 6771 3 the the DT cord-005453-4057qib7 6771 4 effective effective JJ cord-005453-4057qib7 6771 5 management management NN cord-005453-4057qib7 6771 6 of of IN cord-005453-4057qib7 6771 7 hypercalcaemia hypercalcaemia NNP cord-005453-4057qib7 6771 8 in in IN cord-005453-4057qib7 6771 9 a a DT cord-005453-4057qib7 6771 10 patient patient NN cord-005453-4057qib7 6771 11 with with IN cord-005453-4057qib7 6771 12 RANK RANK NNP cord-005453-4057qib7 6771 13 mutation mutation NN cord-005453-4057qib7 6771 14 osteopetrosis osteopetrosis NN cord-005453-4057qib7 6771 15 who who WP cord-005453-4057qib7 6771 16 received receive VBD cord-005453-4057qib7 6771 17 a a DT cord-005453-4057qib7 6771 18 haploidentical haploidentical JJ cord-005453-4057qib7 6771 19 SCT SCT NNP cord-005453-4057qib7 6771 20 . . . cord-005453-4057qib7 6772 1 Methods method NNS cord-005453-4057qib7 6772 2 : : : cord-005453-4057qib7 6773 1 Our -PRON- PRP$ cord-005453-4057qib7 6773 2 patient patient NN cord-005453-4057qib7 6773 3 was be VBD cord-005453-4057qib7 6773 4 diagnosed diagnose VBN cord-005453-4057qib7 6773 5 with with IN cord-005453-4057qib7 6773 6 osteopetrosis osteopetrosis NNP cord-005453-4057qib7 6773 7 at at IN cord-005453-4057qib7 6773 8 2 2 CD cord-005453-4057qib7 6773 9 year year NN cord-005453-4057qib7 6773 10 of of IN cord-005453-4057qib7 6773 11 age age NN cord-005453-4057qib7 6773 12 with with IN cord-005453-4057qib7 6773 13 a a DT cord-005453-4057qib7 6773 14 defect defect NN cord-005453-4057qib7 6773 15 in in IN cord-005453-4057qib7 6773 16 the the DT cord-005453-4057qib7 6773 17 TNFRSF11A TNFRSF11A NNP cord-005453-4057qib7 6773 18 gene gene NN cord-005453-4057qib7 6773 19 which which WDT cord-005453-4057qib7 6773 20 codes code VBZ cord-005453-4057qib7 6773 21 for for IN cord-005453-4057qib7 6773 22 RANK rank NN cord-005453-4057qib7 6773 23 and and CC cord-005453-4057qib7 6773 24 received receive VBD cord-005453-4057qib7 6773 25 a a DT cord-005453-4057qib7 6773 26 maternal maternal JJ cord-005453-4057qib7 6773 27 haploidentical haploidentical JJ cord-005453-4057qib7 6773 28 SCT SCT NNP cord-005453-4057qib7 6773 29 aged age VBN cord-005453-4057qib7 6773 30 4 4 CD cord-005453-4057qib7 6773 31 years year NNS cord-005453-4057qib7 6773 32 . . . cord-005453-4057qib7 6774 1 The the DT cord-005453-4057qib7 6774 2 patients patient NNS cord-005453-4057qib7 6774 3 calcium calcium NN cord-005453-4057qib7 6774 4 levels level NNS cord-005453-4057qib7 6774 5 were be VBD cord-005453-4057qib7 6774 6 monitored monitor VBN cord-005453-4057qib7 6774 7 regularly regularly RB cord-005453-4057qib7 6774 8 post post VB cord-005453-4057qib7 6774 9 SCT SCT NNP cord-005453-4057qib7 6774 10 . . . cord-005453-4057qib7 6775 1 Denosumab Denosumab NNP cord-005453-4057qib7 6775 2 was be VBD cord-005453-4057qib7 6775 3 administered administer VBN cord-005453-4057qib7 6775 4 for for IN cord-005453-4057qib7 6775 5 hypercalcaemia hypercalcaemia NN cord-005453-4057qib7 6775 6 as as IN cord-005453-4057qib7 6775 7 per per IN cord-005453-4057qib7 6775 8 laboratory laboratory NN cord-005453-4057qib7 6775 9 reports report NNS cord-005453-4057qib7 6775 10 or or CC cord-005453-4057qib7 6775 11 clinical clinical JJ cord-005453-4057qib7 6775 12 symptoms symptom NNS cord-005453-4057qib7 6775 13 . . . cord-005453-4057qib7 6776 1 The the DT cord-005453-4057qib7 6776 2 drug drug NN cord-005453-4057qib7 6776 3 was be VBD cord-005453-4057qib7 6776 4 diluted dilute VBN cord-005453-4057qib7 6776 5 with with IN cord-005453-4057qib7 6776 6 water water NN cord-005453-4057qib7 6776 7 for for IN cord-005453-4057qib7 6776 8 injection injection NN cord-005453-4057qib7 6776 9 to to TO cord-005453-4057qib7 6776 10 make make VB cord-005453-4057qib7 6776 11 6mg 6mg NN cord-005453-4057qib7 6776 12 / / SYM cord-005453-4057qib7 6776 13 ml ml NN cord-005453-4057qib7 6776 14 solution solution NN cord-005453-4057qib7 6776 15 to to TO cord-005453-4057qib7 6776 16 facilitate facilitate VB cord-005453-4057qib7 6776 17 subcutaneous subcutaneous JJ cord-005453-4057qib7 6776 18 administration administration NN cord-005453-4057qib7 6776 19 . . . cord-005453-4057qib7 6777 1 Results result NNS cord-005453-4057qib7 6777 2 : : : cord-005453-4057qib7 6778 1 Significant significant JJ cord-005453-4057qib7 6778 2 hypercalcaemia hypercalcaemia NN cord-005453-4057qib7 6778 3 emerged emerge VBD cord-005453-4057qib7 6778 4 on on IN cord-005453-4057qib7 6778 5 day day NN cord-005453-4057qib7 6778 6 +18 +18 CD cord-005453-4057qib7 6778 7 with with IN cord-005453-4057qib7 6778 8 a a DT cord-005453-4057qib7 6778 9 level level NN cord-005453-4057qib7 6778 10 of of IN cord-005453-4057qib7 6778 11 3mmol 3mmol CD cord-005453-4057qib7 6778 12 / / SYM cord-005453-4057qib7 6778 13 L l NN cord-005453-4057qib7 6778 14 and and CC cord-005453-4057qib7 6778 15 treated treat VBN cord-005453-4057qib7 6778 16 with with IN cord-005453-4057qib7 6778 17 hyper hyper JJ cord-005453-4057qib7 6778 18 - - NN cord-005453-4057qib7 6778 19 hydration hydration NN cord-005453-4057qib7 6778 20 and and CC cord-005453-4057qib7 6778 21 diuretics diuretic NNS cord-005453-4057qib7 6778 22 . . . cord-005453-4057qib7 6779 1 This this DT cord-005453-4057qib7 6779 2 was be VBD cord-005453-4057qib7 6779 3 ineffective ineffective JJ cord-005453-4057qib7 6779 4 in in IN cord-005453-4057qib7 6779 5 reducing reduce VBG cord-005453-4057qib7 6779 6 the the DT cord-005453-4057qib7 6779 7 hypercalcaemia hypercalcaemia NN cord-005453-4057qib7 6779 8 ; ; : cord-005453-4057qib7 6779 9 therefore therefore RB cord-005453-4057qib7 6779 10 denosumab denosumab NNP cord-005453-4057qib7 6779 11 was be VBD cord-005453-4057qib7 6779 12 initiated initiate VBN cord-005453-4057qib7 6779 13 on on IN cord-005453-4057qib7 6779 14 day day NN cord-005453-4057qib7 6779 15 +20 +20 CD cord-005453-4057qib7 6779 16 post post NN cord-005453-4057qib7 6779 17 - - NN cord-005453-4057qib7 6779 18 transplant transplant NN cord-005453-4057qib7 6779 19 . . . cord-005453-4057qib7 6780 1 Initial initial JJ cord-005453-4057qib7 6780 2 dosing dosing NN cord-005453-4057qib7 6780 3 was be VBD cord-005453-4057qib7 6780 4 determined determine VBN cord-005453-4057qib7 6780 5 using use VBG cord-005453-4057qib7 6780 6 the the DT cord-005453-4057qib7 6780 7 only only RB cord-005453-4057qib7 6780 8 available available JJ cord-005453-4057qib7 6780 9 paediatric paediatric JJ cord-005453-4057qib7 6780 10 case case NN cord-005453-4057qib7 6780 11 report report NN cord-005453-4057qib7 6780 12 at at IN cord-005453-4057qib7 6780 13 0.13 0.13 CD cord-005453-4057qib7 6780 14 mg mg NNP cord-005453-4057qib7 6780 15 / / SYM cord-005453-4057qib7 6780 16 kg kg NNP cord-005453-4057qib7 6780 17 . . . cord-005453-4057qib7 6781 1 A a DT cord-005453-4057qib7 6781 2 repeated repeated JJ cord-005453-4057qib7 6781 3 larger large JJR cord-005453-4057qib7 6781 4 dose dose NN cord-005453-4057qib7 6781 5 of of IN cord-005453-4057qib7 6781 6 0.19mg 0.19mg CD cord-005453-4057qib7 6781 7 / / SYM cord-005453-4057qib7 6781 8 kg kg NNS cord-005453-4057qib7 6781 9 was be VBD cord-005453-4057qib7 6781 10 given give VBN cord-005453-4057qib7 6781 11 4 4 CD cord-005453-4057qib7 6781 12 days day NNS cord-005453-4057qib7 6781 13 later later RB cord-005453-4057qib7 6781 14 due due IN cord-005453-4057qib7 6781 15 to to IN cord-005453-4057qib7 6781 16 an an DT cord-005453-4057qib7 6781 17 inadequate inadequate JJ cord-005453-4057qib7 6781 18 response response NN cord-005453-4057qib7 6781 19 ( ( -LRB- cord-005453-4057qib7 6781 20 calcium calcium NN cord-005453-4057qib7 6781 21 decreased decrease VBD cord-005453-4057qib7 6781 22 from from IN cord-005453-4057qib7 6781 23 3.9mmol 3.9mmol CD cord-005453-4057qib7 6781 24 / / SYM cord-005453-4057qib7 6781 25 L l NN cord-005453-4057qib7 6781 26 to to IN cord-005453-4057qib7 6781 27 3.80mmol 3.80mmol CD cord-005453-4057qib7 6781 28 / / SYM cord-005453-4057qib7 6781 29 L l NN cord-005453-4057qib7 6781 30 ) ) -RRB- cord-005453-4057qib7 6781 31 . . . cord-005453-4057qib7 6782 1 The the DT cord-005453-4057qib7 6782 2 calcium calcium NN cord-005453-4057qib7 6782 3 decreased decrease VBD cord-005453-4057qib7 6782 4 to to IN cord-005453-4057qib7 6782 5 1.93mmol 1.93mmol CD cord-005453-4057qib7 6782 6 / / SYM cord-005453-4057qib7 6782 7 L l NN cord-005453-4057qib7 6782 8 after after IN cord-005453-4057qib7 6782 9 this this DT cord-005453-4057qib7 6782 10 dose dose NN cord-005453-4057qib7 6782 11 . . . cord-005453-4057qib7 6783 1 Four four CD cord-005453-4057qib7 6783 2 weeks week NNS cord-005453-4057qib7 6783 3 later later RB cord-005453-4057qib7 6783 4 a a DT cord-005453-4057qib7 6783 5 third third JJ cord-005453-4057qib7 6783 6 dose dose NN cord-005453-4057qib7 6783 7 was be VBD cord-005453-4057qib7 6783 8 required require VBN cord-005453-4057qib7 6783 9 at at IN cord-005453-4057qib7 6783 10 0.26mg 0.26mg CD cord-005453-4057qib7 6783 11 / / SYM cord-005453-4057qib7 6783 12 kg kg NNS cord-005453-4057qib7 6783 13 as as IN cord-005453-4057qib7 6783 14 the the DT cord-005453-4057qib7 6783 15 calcium calcium NN cord-005453-4057qib7 6783 16 level level NN cord-005453-4057qib7 6783 17 had have VBD cord-005453-4057qib7 6783 18 increased increase VBN cord-005453-4057qib7 6783 19 to to IN cord-005453-4057qib7 6783 20 4.1mmol 4.1mmol CD cord-005453-4057qib7 6783 21 / / SYM cord-005453-4057qib7 6783 22 L. L. NNP cord-005453-4057qib7 6784 1 The the DT cord-005453-4057qib7 6784 2 dose dose NN cord-005453-4057qib7 6784 3 was be VBD cord-005453-4057qib7 6784 4 further further RB cord-005453-4057qib7 6784 5 increased increase VBN cord-005453-4057qib7 6784 6 to to IN cord-005453-4057qib7 6784 7 0.32mg 0.32mg CD cord-005453-4057qib7 6784 8 / / SYM cord-005453-4057qib7 6784 9 kg kg NNS cord-005453-4057qib7 6784 10 for for IN cord-005453-4057qib7 6784 11 another another DT cord-005453-4057qib7 6784 12 four four CD cord-005453-4057qib7 6784 13 doses dose NNS cord-005453-4057qib7 6784 14 and and CC cord-005453-4057qib7 6784 15 then then RB cord-005453-4057qib7 6784 16 further further RB cord-005453-4057qib7 6784 17 increased increase VBD cord-005453-4057qib7 6784 18 to to IN cord-005453-4057qib7 6784 19 0.65mg 0.65mg CD cord-005453-4057qib7 6784 20 / / SYM cord-005453-4057qib7 6784 21 kg kg NNS cord-005453-4057qib7 6784 22 for for IN cord-005453-4057qib7 6784 23 another another DT cord-005453-4057qib7 6784 24 3 3 CD cord-005453-4057qib7 6784 25 doses dose NNS cord-005453-4057qib7 6784 26 and and CC cord-005453-4057qib7 6784 27 repeated repeat VBD cord-005453-4057qib7 6784 28 every every DT cord-005453-4057qib7 6784 29 7 7 CD cord-005453-4057qib7 6784 30 weeks week NNS cord-005453-4057qib7 6784 31 . . . cord-005453-4057qib7 6785 1 Normalisation Normalisation NNP cord-005453-4057qib7 6785 2 , , , cord-005453-4057qib7 6785 3 but but CC cord-005453-4057qib7 6785 4 not not RB cord-005453-4057qib7 6785 5 excessive excessive JJ cord-005453-4057qib7 6785 6 drop drop NN cord-005453-4057qib7 6785 7 in in IN cord-005453-4057qib7 6785 8 calcium calcium NN cord-005453-4057qib7 6785 9 was be VBD cord-005453-4057qib7 6785 10 achieved achieve VBN cord-005453-4057qib7 6785 11 with with IN cord-005453-4057qib7 6785 12 these these DT cord-005453-4057qib7 6785 13 larger large JJR cord-005453-4057qib7 6785 14 doses dose NNS cord-005453-4057qib7 6785 15 . . . cord-005453-4057qib7 6786 1 Over over IN cord-005453-4057qib7 6786 2 the the DT cord-005453-4057qib7 6786 3 9 9 CD cord-005453-4057qib7 6786 4 month month NN cord-005453-4057qib7 6786 5 follow follow VB cord-005453-4057qib7 6786 6 up up RP cord-005453-4057qib7 6786 7 post post JJ cord-005453-4057qib7 6786 8 - - JJ cord-005453-4057qib7 6786 9 transplant transplant NN cord-005453-4057qib7 6786 10 there there EX cord-005453-4057qib7 6786 11 were be VBD cord-005453-4057qib7 6786 12 three three CD cord-005453-4057qib7 6786 13 admissions admission NNS cord-005453-4057qib7 6786 14 lasting last VBG cord-005453-4057qib7 6786 15 less less JJR cord-005453-4057qib7 6786 16 than than IN cord-005453-4057qib7 6786 17 24 24 CD cord-005453-4057qib7 6786 18 hours hour NNS cord-005453-4057qib7 6786 19 for for IN cord-005453-4057qib7 6786 20 symptoms symptom NNS cord-005453-4057qib7 6786 21 of of IN cord-005453-4057qib7 6786 22 hypercalcaemia hypercalcaemia NN cord-005453-4057qib7 6786 23 . . . cord-005453-4057qib7 6787 1 These these DT cord-005453-4057qib7 6787 2 were be VBD cord-005453-4057qib7 6787 3 managed manage VBN cord-005453-4057qib7 6787 4 with with IN cord-005453-4057qib7 6787 5 denosumab denosumab NNP cord-005453-4057qib7 6787 6 administration administration NN cord-005453-4057qib7 6787 7 and and CC cord-005453-4057qib7 6787 8 hyper hyper JJ cord-005453-4057qib7 6787 9 - - NN cord-005453-4057qib7 6787 10 hydration hydration NN cord-005453-4057qib7 6787 11 . . . cord-005453-4057qib7 6788 1 The the DT cord-005453-4057qib7 6788 2 remaining remain VBG cord-005453-4057qib7 6788 3 doses dose NNS cord-005453-4057qib7 6788 4 were be VBD cord-005453-4057qib7 6788 5 given give VBN cord-005453-4057qib7 6788 6 in in IN cord-005453-4057qib7 6788 7 an an DT cord-005453-4057qib7 6788 8 outpatient outpatient NN cord-005453-4057qib7 6788 9 setting setting NN cord-005453-4057qib7 6788 10 . . . cord-005453-4057qib7 6789 1 Conclusions conclusion NNS cord-005453-4057qib7 6789 2 : : : cord-005453-4057qib7 6790 1 Denosumab Denosumab NNP cord-005453-4057qib7 6790 2 can can MD cord-005453-4057qib7 6790 3 be be VB cord-005453-4057qib7 6790 4 safely safely RB cord-005453-4057qib7 6790 5 used use VBN cord-005453-4057qib7 6790 6 as as IN cord-005453-4057qib7 6790 7 a a DT cord-005453-4057qib7 6790 8 first first JJ cord-005453-4057qib7 6790 9 line line NN cord-005453-4057qib7 6790 10 agent agent NN cord-005453-4057qib7 6790 11 in in IN cord-005453-4057qib7 6790 12 treating treat VBG cord-005453-4057qib7 6790 13 post post JJ cord-005453-4057qib7 6790 14 stem stem NN cord-005453-4057qib7 6790 15 cell cell NN cord-005453-4057qib7 6790 16 transplant transplant NN cord-005453-4057qib7 6790 17 hypercalcemia hypercalcemia NN cord-005453-4057qib7 6790 18 in in IN cord-005453-4057qib7 6790 19 patients patient NNS cord-005453-4057qib7 6790 20 with with IN cord-005453-4057qib7 6790 21 osteopetrosis osteopetrosis NN cord-005453-4057qib7 6790 22 . . . cord-005453-4057qib7 6791 1 A a DT cord-005453-4057qib7 6791 2 dose dose NN cord-005453-4057qib7 6791 3 of of IN cord-005453-4057qib7 6791 4 0.3mg 0.3mg CD cord-005453-4057qib7 6791 5 / / SYM cord-005453-4057qib7 6791 6 kg kg NN cord-005453-4057qib7 6791 7 is be VBZ cord-005453-4057qib7 6791 8 required require VBN cord-005453-4057qib7 6791 9 as as IN cord-005453-4057qib7 6791 10 an an DT cord-005453-4057qib7 6791 11 initial initial JJ cord-005453-4057qib7 6791 12 starting starting NN cord-005453-4057qib7 6791 13 dose dose NN cord-005453-4057qib7 6791 14 in in IN cord-005453-4057qib7 6791 15 order order NN cord-005453-4057qib7 6791 16 to to TO cord-005453-4057qib7 6791 17 control control VB cord-005453-4057qib7 6791 18 hypercalcemia hypercalcemia NN cord-005453-4057qib7 6791 19 . . . cord-005453-4057qib7 6792 1 This this DT cord-005453-4057qib7 6792 2 is be VBZ cord-005453-4057qib7 6792 3 a a DT cord-005453-4057qib7 6792 4 new new JJ cord-005453-4057qib7 6792 5 higher high JJR cord-005453-4057qib7 6792 6 dose dose NN cord-005453-4057qib7 6792 7 than than IN cord-005453-4057qib7 6792 8 previously previously RB cord-005453-4057qib7 6792 9 suggested suggest VBN cord-005453-4057qib7 6792 10 by by IN cord-005453-4057qib7 6792 11 the the DT cord-005453-4057qib7 6792 12 original original JJ cord-005453-4057qib7 6792 13 report report NN cord-005453-4057qib7 6792 14 . . . cord-005453-4057qib7 6793 1 Denosumab Denosumab NNP cord-005453-4057qib7 6793 2 can can MD cord-005453-4057qib7 6793 3 be be VB cord-005453-4057qib7 6793 4 effective effective JJ cord-005453-4057qib7 6793 5 even even RB cord-005453-4057qib7 6793 6 after after IN cord-005453-4057qib7 6793 7 dilution dilution NN cord-005453-4057qib7 6793 8 and and CC cord-005453-4057qib7 6793 9 safely safely RB cord-005453-4057qib7 6793 10 given give VBN cord-005453-4057qib7 6793 11 in in IN cord-005453-4057qib7 6793 12 children child NNS cord-005453-4057qib7 6793 13 weighing weigh VBG cord-005453-4057qib7 6793 14 less less JJR cord-005453-4057qib7 6793 15 than than IN cord-005453-4057qib7 6793 16 10 10 CD cord-005453-4057qib7 6793 17 kg kg NNS cord-005453-4057qib7 6793 18 . . . cord-005453-4057qib7 6794 1 Disclosure disclosure NN cord-005453-4057qib7 6794 2 : : : cord-005453-4057qib7 6794 3 Nothing nothing NN cord-005453-4057qib7 6794 4 to to TO cord-005453-4057qib7 6794 5 Declare declare VB cord-005453-4057qib7 6794 6 Methods method NNS cord-005453-4057qib7 6794 7 : : : cord-005453-4057qib7 6794 8 The the DT cord-005453-4057qib7 6794 9 clinical clinical JJ cord-005453-4057qib7 6794 10 , , , cord-005453-4057qib7 6794 11 laboratory laboratory NN cord-005453-4057qib7 6794 12 and and CC cord-005453-4057qib7 6794 13 molecular molecular JJ cord-005453-4057qib7 6794 14 aspects aspect NNS cord-005453-4057qib7 6794 15 of of IN cord-005453-4057qib7 6794 16 this this DT cord-005453-4057qib7 6794 17 Italian italian JJ cord-005453-4057qib7 6794 18 male male JJ cord-005453-4057qib7 6794 19 patient patient NN cord-005453-4057qib7 6794 20 who who WP cord-005453-4057qib7 6794 21 developed develop VBD cord-005453-4057qib7 6794 22 such such PDT cord-005453-4057qib7 6794 23 a a DT cord-005453-4057qib7 6794 24 complication complication NN cord-005453-4057qib7 6794 25 were be VBD cord-005453-4057qib7 6794 26 collected collect VBN cord-005453-4057qib7 6794 27 and and CC cord-005453-4057qib7 6794 28 presented present VBN cord-005453-4057qib7 6794 29 in in IN cord-005453-4057qib7 6794 30 order order NN cord-005453-4057qib7 6794 31 to to TO cord-005453-4057qib7 6794 32 discuss discuss VB cord-005453-4057qib7 6794 33 the the DT cord-005453-4057qib7 6794 34 origin origin NN cord-005453-4057qib7 6794 35 , , , cord-005453-4057qib7 6794 36 clinical clinical JJ cord-005453-4057qib7 6794 37 outcome outcome NN cord-005453-4057qib7 6794 38 and and CC cord-005453-4057qib7 6794 39 management management NN cord-005453-4057qib7 6794 40 of of IN cord-005453-4057qib7 6794 41 this this DT cord-005453-4057qib7 6794 42 very very RB cord-005453-4057qib7 6794 43 rare rare JJ cord-005453-4057qib7 6794 44 post post JJ cord-005453-4057qib7 6794 45 - - JJ cord-005453-4057qib7 6794 46 transplant transplant JJ cord-005453-4057qib7 6794 47 event event NN cord-005453-4057qib7 6794 48 . . . cord-005453-4057qib7 6795 1 Results result NNS cord-005453-4057qib7 6795 2 : : : cord-005453-4057qib7 6796 1 A a DT cord-005453-4057qib7 6796 2 68-years 68-years CD cord-005453-4057qib7 6796 3 - - HYPH cord-005453-4057qib7 6796 4 old old JJ cord-005453-4057qib7 6796 5 man man NN cord-005453-4057qib7 6796 6 affected affect VBN cord-005453-4057qib7 6796 7 by by IN cord-005453-4057qib7 6796 8 a a DT cord-005453-4057qib7 6796 9 high high JJ cord-005453-4057qib7 6796 10 - - HYPH cord-005453-4057qib7 6796 11 risk risk NN cord-005453-4057qib7 6796 12 chromosomally chromosomally RB cord-005453-4057qib7 6796 13 abnormal abnormal JJ cord-005453-4057qib7 6796 14 , , , cord-005453-4057qib7 6796 15 Ph1- Ph1- NNP cord-005453-4057qib7 6796 16 , , , cord-005453-4057qib7 6796 17 MLL MLL NNP cord-005453-4057qib7 6796 18 - - HYPH cord-005453-4057qib7 6796 19 pro pro NN cord-005453-4057qib7 6796 20 - - JJ cord-005453-4057qib7 6796 21 B b JJ cord-005453-4057qib7 6796 22 ( ( -LRB- cord-005453-4057qib7 6796 23 EGIL EGIL NNP cord-005453-4057qib7 6796 24 B B NNP cord-005453-4057qib7 6796 25 - - : cord-005453-4057qib7 6796 26 I I NNP cord-005453-4057qib7 6796 27 ) ) -RRB- cord-005453-4057qib7 6796 28 ALL all DT cord-005453-4057qib7 6796 29 relapsed relapse VBD cord-005453-4057qib7 6796 30 during during IN cord-005453-4057qib7 6796 31 maintenance maintenance NN cord-005453-4057qib7 6796 32 treatment treatment NN cord-005453-4057qib7 6796 33 , , , cord-005453-4057qib7 6796 34 nonresponsive nonresponsive JJ cord-005453-4057qib7 6796 35 to to TO cord-005453-4057qib7 6796 36 re re VB cord-005453-4057qib7 6796 37 - - NN cord-005453-4057qib7 6796 38 induction induction JJ cord-005453-4057qib7 6796 39 chemotherapy chemotherapy NN cord-005453-4057qib7 6796 40 , , , cord-005453-4057qib7 6796 41 in in IN cord-005453-4057qib7 6796 42 second second JJ cord-005453-4057qib7 6796 43 complete complete JJ cord-005453-4057qib7 6796 44 remission remission NN cord-005453-4057qib7 6796 45 ( ( -LRB- cord-005453-4057qib7 6796 46 II II NNP cord-005453-4057qib7 6796 47 CR CR NNP cord-005453-4057qib7 6796 48 ) ) -RRB- cord-005453-4057qib7 6796 49 after after IN cord-005453-4057qib7 6796 50 Blinatumumab Blinatumumab NNP cord-005453-4057qib7 6796 51 treatment treatment NN cord-005453-4057qib7 6796 52 received receive VBD cord-005453-4057qib7 6796 53 a a DT cord-005453-4057qib7 6796 54 female female JJ cord-005453-4057qib7 6796 55 CB CB NNP cord-005453-4057qib7 6796 56 transplant transplant NN cord-005453-4057qib7 6796 57 . . . cord-005453-4057qib7 6797 1 According accord VBG cord-005453-4057qib7 6797 2 to to IN cord-005453-4057qib7 6797 3 Sorror Sorror NNP cord-005453-4057qib7 6797 4 's 's POS cord-005453-4057qib7 6797 5 and and CC cord-005453-4057qib7 6797 6 EBMT EBMT NNP cord-005453-4057qib7 6797 7 scores score NNS cord-005453-4057qib7 6797 8 he -PRON- PRP cord-005453-4057qib7 6797 9 was be VBD cord-005453-4057qib7 6797 10 considered consider VBN cord-005453-4057qib7 6797 11 a a DT cord-005453-4057qib7 6797 12 high high JJ cord-005453-4057qib7 6797 13 - - HYPH cord-005453-4057qib7 6797 14 risk risk NN cord-005453-4057qib7 6797 15 transplant transplant NN cord-005453-4057qib7 6797 16 . . . cord-005453-4057qib7 6798 1 The the DT cord-005453-4057qib7 6798 2 patient patient NN cord-005453-4057qib7 6798 3 and and CC cord-005453-4057qib7 6798 4 the the DT cord-005453-4057qib7 6798 5 CB CB NNP cord-005453-4057qib7 6798 6 unit unit NN cord-005453-4057qib7 6798 7 were be VBD cord-005453-4057qib7 6798 8 sex sex NN cord-005453-4057qib7 6798 9 - - HYPH cord-005453-4057qib7 6798 10 mismatched mismatched JJ cord-005453-4057qib7 6798 11 , , , cord-005453-4057qib7 6798 12 shared share VBD cord-005453-4057qib7 6798 13 the the DT cord-005453-4057qib7 6798 14 same same JJ cord-005453-4057qib7 6798 15 blood blood NN cord-005453-4057qib7 6798 16 groups group NNS cord-005453-4057qib7 6798 17 and and CC cord-005453-4057qib7 6798 18 were be VBD cord-005453-4057qib7 6798 19 both both DT cord-005453-4057qib7 6798 20 CMV+/EBV+ CMV+/EBV+ NNS cord-005453-4057qib7 6798 21 . . . cord-005453-4057qib7 6799 1 He -PRON- PRP cord-005453-4057qib7 6799 2 received receive VBD cord-005453-4057qib7 6799 3 a a DT cord-005453-4057qib7 6799 4 TBF tbf NN cord-005453-4057qib7 6799 5 conditioning conditioning NN cord-005453-4057qib7 6799 6 regimen regimen NN cord-005453-4057qib7 6799 7 that that WDT cord-005453-4057qib7 6799 8 was be VBD cord-005453-4057qib7 6799 9 followed follow VBN cord-005453-4057qib7 6799 10 by by IN cord-005453-4057qib7 6799 11 the the DT cord-005453-4057qib7 6799 12 infusion infusion NN cord-005453-4057qib7 6799 13 of of IN cord-005453-4057qib7 6799 14 0.54x10 0.54x10 CD cord-005453-4057qib7 6799 15 5 5 CD cord-005453-4057qib7 6799 16 /kg /kg . cord-005453-4057qib7 6799 17 CD34 CD34 NNP cord-005453-4057qib7 6799 18 + + CC cord-005453-4057qib7 6799 19 CB CB NNP cord-005453-4057qib7 6799 20 cells cell NNS cord-005453-4057qib7 6799 21 . . . cord-005453-4057qib7 6800 1 GVHD GVHD NNP cord-005453-4057qib7 6800 2 prophylaxis prophylaxis NN cord-005453-4057qib7 6800 3 consisted consist VBD cord-005453-4057qib7 6800 4 of of IN cord-005453-4057qib7 6800 5 rabbit rabbit NN cord-005453-4057qib7 6800 6 ATG ATG NNP cord-005453-4057qib7 6800 7 , , , cord-005453-4057qib7 6800 8 Cyclosporine Cyclosporine NNP cord-005453-4057qib7 6800 9 A A NNP cord-005453-4057qib7 6800 10 ( ( -LRB- cord-005453-4057qib7 6800 11 CsA csa NN cord-005453-4057qib7 6800 12 ) ) -RRB- cord-005453-4057qib7 6800 13 and and CC cord-005453-4057qib7 6800 14 mycophenolate mycophenolate NNP cord-005453-4057qib7 6800 15 mophetyl mophetyl NNP cord-005453-4057qib7 6800 16 ( ( -LRB- cord-005453-4057qib7 6800 17 MMF MMF NNP cord-005453-4057qib7 6800 18 ) ) -RRB- cord-005453-4057qib7 6800 19 . . . cord-005453-4057qib7 6801 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 6801 2 engraftment engraftment NN cord-005453-4057qib7 6801 3 occurred occur VBD cord-005453-4057qib7 6801 4 on on IN cord-005453-4057qib7 6801 5 day day NN cord-005453-4057qib7 6801 6 +28 +28 NNS cord-005453-4057qib7 6801 7 , , , cord-005453-4057qib7 6801 8 whereas whereas IN cord-005453-4057qib7 6801 9 platelets platelet NNS cord-005453-4057qib7 6801 10 were be VBD cord-005453-4057qib7 6801 11 never never RB cord-005453-4057qib7 6801 12 > > XX cord-005453-4057qib7 6802 1 20.000 20.000 CD cord-005453-4057qib7 6802 2 / / SYM cord-005453-4057qib7 6802 3 μl μl NN cord-005453-4057qib7 6802 4 . . . cord-005453-4057qib7 6803 1 On on IN cord-005453-4057qib7 6803 2 day day NN cord-005453-4057qib7 6803 3 +67 +67 NNP cord-005453-4057qib7 6803 4 a a DT cord-005453-4057qib7 6803 5 2 2 CD cord-005453-4057qib7 6803 6 cm cm NN cord-005453-4057qib7 6803 7 bulged bulge VBN cord-005453-4057qib7 6803 8 area area NN cord-005453-4057qib7 6803 9 became become VBD cord-005453-4057qib7 6803 10 apparent apparent JJ cord-005453-4057qib7 6803 11 on on IN cord-005453-4057qib7 6803 12 the the DT cord-005453-4057qib7 6803 13 left left JJ cord-005453-4057qib7 6803 14 parietal parietal JJ cord-005453-4057qib7 6803 15 region region NN cord-005453-4057qib7 6803 16 of of IN cord-005453-4057qib7 6803 17 the the DT cord-005453-4057qib7 6803 18 skull skull NN cord-005453-4057qib7 6803 19 . . . cord-005453-4057qib7 6804 1 An an DT cord-005453-4057qib7 6804 2 echotomography echotomography NN cord-005453-4057qib7 6804 3 showed show VBD cord-005453-4057qib7 6804 4 that that IN cord-005453-4057qib7 6804 5 the the DT cord-005453-4057qib7 6804 6 lesion lesion NN cord-005453-4057qib7 6804 7 adhered adhere VBN cord-005453-4057qib7 6804 8 to to IN cord-005453-4057qib7 6804 9 the the DT cord-005453-4057qib7 6804 10 bone bone NN cord-005453-4057qib7 6804 11 without without IN cord-005453-4057qib7 6804 12 infiltrating infiltrate VBG cord-005453-4057qib7 6804 13 it -PRON- PRP cord-005453-4057qib7 6804 14 and and CC cord-005453-4057qib7 6804 15 lacked lack VBD cord-005453-4057qib7 6804 16 blood blood NN cord-005453-4057qib7 6804 17 vessels vessel NNS cord-005453-4057qib7 6804 18 and and CC cord-005453-4057qib7 6804 19 suggested suggest VBD cord-005453-4057qib7 6804 20 that that IN cord-005453-4057qib7 6804 21 it -PRON- PRP cord-005453-4057qib7 6804 22 may may MD cord-005453-4057qib7 6804 23 be be VB cord-005453-4057qib7 6804 24 either either CC cord-005453-4057qib7 6804 25 a a DT cord-005453-4057qib7 6804 26 site site NN cord-005453-4057qib7 6804 27 of of IN cord-005453-4057qib7 6804 28 disease disease NN cord-005453-4057qib7 6804 29 relapse relapse NN cord-005453-4057qib7 6804 30 or or CC cord-005453-4057qib7 6804 31 an an DT cord-005453-4057qib7 6804 32 area area NN cord-005453-4057qib7 6804 33 of of IN cord-005453-4057qib7 6804 34 infection infection NN cord-005453-4057qib7 6804 35 . . . cord-005453-4057qib7 6805 1 At at IN cord-005453-4057qib7 6805 2 the the DT cord-005453-4057qib7 6805 3 same same JJ cord-005453-4057qib7 6805 4 time time NN cord-005453-4057qib7 6805 5 a a DT cord-005453-4057qib7 6805 6 bone bone NN cord-005453-4057qib7 6805 7 marrow marrow NN cord-005453-4057qib7 6805 8 ( ( -LRB- cord-005453-4057qib7 6805 9 BM BM NNP cord-005453-4057qib7 6805 10 ) ) -RRB- cord-005453-4057qib7 6805 11 aspiration aspiration NN cord-005453-4057qib7 6805 12 showed show VBD cord-005453-4057qib7 6805 13 morphological morphological JJ cord-005453-4057qib7 6805 14 CR CR NNP cord-005453-4057qib7 6805 15 confirmed confirm VBN cord-005453-4057qib7 6805 16 by by IN cord-005453-4057qib7 6805 17 immune immune JJ cord-005453-4057qib7 6805 18 - - HYPH cord-005453-4057qib7 6805 19 phenotypic phenotypic JJ cord-005453-4057qib7 6805 20 studies study NNS cord-005453-4057qib7 6805 21 and and CC cord-005453-4057qib7 6805 22 X x NN cord-005453-4057qib7 6805 23 - - NN cord-005453-4057qib7 6805 24 Y Y NNP cord-005453-4057qib7 6805 25 FISH fish NN cord-005453-4057qib7 6805 26 a a DT cord-005453-4057qib7 6805 27 complete complete JJ cord-005453-4057qib7 6805 28 chimera chimera NN cord-005453-4057qib7 6805 29 . . . cord-005453-4057qib7 6806 1 Since since IN cord-005453-4057qib7 6806 2 the the DT cord-005453-4057qib7 6806 3 patient patient NN cord-005453-4057qib7 6806 4 was be VBD cord-005453-4057qib7 6806 5 still still RB cord-005453-4057qib7 6806 6 febrile febrile JJ cord-005453-4057qib7 6806 7 no no DT cord-005453-4057qib7 6806 8 biopsy biopsy NN cord-005453-4057qib7 6806 9 was be VBD cord-005453-4057qib7 6806 10 performed perform VBN cord-005453-4057qib7 6806 11 , , , cord-005453-4057qib7 6806 12 but but CC cord-005453-4057qib7 6806 13 on on IN cord-005453-4057qib7 6806 14 day day NN cord-005453-4057qib7 6806 15 +94 +94 NN cord-005453-4057qib7 6806 16 the the DT cord-005453-4057qib7 6806 17 axial axial JJ cord-005453-4057qib7 6806 18 diameter diameter NN cord-005453-4057qib7 6806 19 of of IN cord-005453-4057qib7 6806 20 the the DT cord-005453-4057qib7 6806 21 lesion lesion NN cord-005453-4057qib7 6806 22 that that IN cord-005453-4057qib7 6806 23 on on IN cord-005453-4057qib7 6806 24 a a DT cord-005453-4057qib7 6806 25 CT CT NNP cord-005453-4057qib7 6806 26 scan scan NN cord-005453-4057qib7 6806 27 showed show VBD cord-005453-4057qib7 6806 28 the the DT cord-005453-4057qib7 6806 29 same same JJ cord-005453-4057qib7 6806 30 appearance appearance NN cord-005453-4057qib7 6806 31 revealed reveal VBN cord-005453-4057qib7 6806 32 by by IN cord-005453-4057qib7 6806 33 the the DT cord-005453-4057qib7 6806 34 previous previous JJ cord-005453-4057qib7 6806 35 echo echo NN cord-005453-4057qib7 6806 36 - - HYPH cord-005453-4057qib7 6806 37 tomography tomography NN cord-005453-4057qib7 6806 38 increased increase VBD cord-005453-4057qib7 6806 39 to to IN cord-005453-4057qib7 6806 40 4 4 CD cord-005453-4057qib7 6806 41 cm cm NNS cord-005453-4057qib7 6806 42 . . . cord-005453-4057qib7 6807 1 Thus thus RB cord-005453-4057qib7 6807 2 , , , cord-005453-4057qib7 6807 3 the the DT cord-005453-4057qib7 6807 4 lesion lesion NN cord-005453-4057qib7 6807 5 was be VBD cord-005453-4057qib7 6807 6 surgically surgically RB cord-005453-4057qib7 6807 7 removed remove VBN cord-005453-4057qib7 6807 8 and and CC cord-005453-4057qib7 6807 9 histological histological JJ cord-005453-4057qib7 6807 10 examination examination NN cord-005453-4057qib7 6807 11 showed show VBD cord-005453-4057qib7 6807 12 CD33 CD33 NNP cord-005453-4057qib7 6807 13 + + CC cord-005453-4057qib7 6807 14 , , , cord-005453-4057qib7 6807 15 CD14+/- CD14+/- NNP cord-005453-4057qib7 6807 16 , , , cord-005453-4057qib7 6808 1 CD163+/- CD163+/- NNP cord-005453-4057qib7 6808 2 , , , cord-005453-4057qib7 6808 3 CD45 CD45 NNP cord-005453-4057qib7 6808 4 / / SYM cord-005453-4057qib7 6808 5 LCA+/- LCA+/- NNP cord-005453-4057qib7 6808 6 , , , cord-005453-4057qib7 6808 7 CD21- CD21- NNP cord-005453-4057qib7 6808 8 , , , cord-005453-4057qib7 6808 9 CD23- CD23- NNP cord-005453-4057qib7 6808 10 , , , cord-005453-4057qib7 6808 11 CD35- CD35- NNP cord-005453-4057qib7 6808 12 , , , cord-005453-4057qib7 6808 13 CD207- CD207- NNP cord-005453-4057qib7 6808 14 , , , cord-005453-4057qib7 6808 15 and and CC cord-005453-4057qib7 6808 16 S100-neoplastic s100-neoplastic JJ cord-005453-4057qib7 6808 17 cells cell NNS cord-005453-4057qib7 6808 18 whose whose WP$ cord-005453-4057qib7 6808 19 phenotype phenotype NN cord-005453-4057qib7 6808 20 suggested suggest VBD cord-005453-4057qib7 6808 21 a a DT cord-005453-4057qib7 6808 22 granulocytic granulocytic JJ cord-005453-4057qib7 6808 23 sarcoma sarcoma NN cord-005453-4057qib7 6808 24 rather rather RB cord-005453-4057qib7 6808 25 than than IN cord-005453-4057qib7 6808 26 a a DT cord-005453-4057qib7 6808 27 histiocytic histiocytic JJ cord-005453-4057qib7 6808 28 sarcoma sarcoma NN cord-005453-4057qib7 6808 29 . . . cord-005453-4057qib7 6809 1 Immuno immuno JJ cord-005453-4057qib7 6809 2 - - HYPH cord-005453-4057qib7 6809 3 chemistry chemistry NN cord-005453-4057qib7 6809 4 confirmed confirm VBD cord-005453-4057qib7 6809 5 this this DT cord-005453-4057qib7 6809 6 suggestion suggestion NN cord-005453-4057qib7 6809 7 by by IN cord-005453-4057qib7 6809 8 showing show VBG cord-005453-4057qib7 6809 9 a a DT cord-005453-4057qib7 6809 10 nuclear nuclear JJ cord-005453-4057qib7 6809 11 NPM1 NPM1 NNP cord-005453-4057qib7 6809 12 positivity positivity NN cord-005453-4057qib7 6809 13 . . . cord-005453-4057qib7 6810 1 FISH FISH NNP cord-005453-4057qib7 6810 2 studies study NNS cord-005453-4057qib7 6810 3 demonstrated demonstrate VBD cord-005453-4057qib7 6810 4 that that IN cord-005453-4057qib7 6810 5 these these DT cord-005453-4057qib7 6810 6 neoplastic neoplastic JJ cord-005453-4057qib7 6810 7 cells cell NNS cord-005453-4057qib7 6810 8 were be VBD cord-005453-4057qib7 6810 9 of of IN cord-005453-4057qib7 6810 10 recipient recipient NN cord-005453-4057qib7 6810 11 's 's POS cord-005453-4057qib7 6810 12 origin origin NN cord-005453-4057qib7 6810 13 . . . cord-005453-4057qib7 6811 1 A a DT cord-005453-4057qib7 6811 2 novel novel JJ cord-005453-4057qib7 6811 3 BM BM NNP cord-005453-4057qib7 6811 4 aspiration aspiration NN cord-005453-4057qib7 6811 5 showed show VBD cord-005453-4057qib7 6811 6 CR CR NNP cord-005453-4057qib7 6811 7 confirmed confirm VBN cord-005453-4057qib7 6811 8 by by IN cord-005453-4057qib7 6811 9 immune immune JJ cord-005453-4057qib7 6811 10 - - HYPH cord-005453-4057qib7 6811 11 phenotypic phenotypic JJ cord-005453-4057qib7 6811 12 studies study NNS cord-005453-4057qib7 6811 13 and and CC cord-005453-4057qib7 6811 14 FISH FISH NNP cord-005453-4057qib7 6811 15 revealed reveal VBD cord-005453-4057qib7 6811 16 a a DT cord-005453-4057qib7 6811 17 complete complete JJ cord-005453-4057qib7 6811 18 chimera chimera NN cord-005453-4057qib7 6811 19 . . . cord-005453-4057qib7 6812 1 Since since IN cord-005453-4057qib7 6812 2 the the DT cord-005453-4057qib7 6812 3 patient patient NN cord-005453-4057qib7 6812 4 was be VBD cord-005453-4057qib7 6812 5 still still RB cord-005453-4057qib7 6812 6 pancytopenic pancytopenic JJ cord-005453-4057qib7 6812 7 due due JJ cord-005453-4057qib7 6812 8 to to IN cord-005453-4057qib7 6812 9 anti anti JJ cord-005453-4057qib7 6812 10 - - JJ cord-005453-4057qib7 6812 11 CMV CMV NNP cord-005453-4057qib7 6812 12 treatment treatment NN cord-005453-4057qib7 6812 13 , , , cord-005453-4057qib7 6812 14 radiotherapy radiotherapy NN cord-005453-4057qib7 6812 15 with with IN cord-005453-4057qib7 6812 16 18Gy 18gy CD cord-005453-4057qib7 6812 17 in in IN cord-005453-4057qib7 6812 18 nine nine CD cord-005453-4057qib7 6812 19 fractions fraction NNS cord-005453-4057qib7 6812 20 were be VBD cord-005453-4057qib7 6812 21 given give VBN cord-005453-4057qib7 6812 22 and and CC cord-005453-4057qib7 6812 23 the the DT cord-005453-4057qib7 6812 24 lesion lesion NN cord-005453-4057qib7 6812 25 completely completely RB cord-005453-4057qib7 6812 26 resolved resolve VBD cord-005453-4057qib7 6812 27 . . . cord-005453-4057qib7 6813 1 Conclusions conclusion NNS cord-005453-4057qib7 6813 2 : : : cord-005453-4057qib7 6814 1 A a DT cord-005453-4057qib7 6814 2 granulocytic granulocytic JJ cord-005453-4057qib7 6814 3 sarcoma sarcoma NN cord-005453-4057qib7 6814 4 of of IN cord-005453-4057qib7 6814 5 recipient recipient NN cord-005453-4057qib7 6814 6 's 's POS cord-005453-4057qib7 6814 7 origin origin NN cord-005453-4057qib7 6814 8 occurring occur VBG cord-005453-4057qib7 6814 9 three three CD cord-005453-4057qib7 6814 10 months month NNS cord-005453-4057qib7 6814 11 after after IN cord-005453-4057qib7 6814 12 a a DT cord-005453-4057qib7 6814 13 CB CB NNP cord-005453-4057qib7 6814 14 transplant transplant NN cord-005453-4057qib7 6814 15 is be VBZ cord-005453-4057qib7 6814 16 a a DT cord-005453-4057qib7 6814 17 very very RB cord-005453-4057qib7 6814 18 rare rare JJ cord-005453-4057qib7 6814 19 and and CC cord-005453-4057qib7 6814 20 unusual unusual JJ cord-005453-4057qib7 6814 21 event event NN cord-005453-4057qib7 6814 22 . . . cord-005453-4057qib7 6815 1 In in IN cord-005453-4057qib7 6815 2 order order NN cord-005453-4057qib7 6815 3 to to TO cord-005453-4057qib7 6815 4 explain explain VB cord-005453-4057qib7 6815 5 such such PDT cord-005453-4057qib7 6815 6 a a DT cord-005453-4057qib7 6815 7 complication complication NN cord-005453-4057qib7 6815 8 we -PRON- PRP cord-005453-4057qib7 6815 9 suggest suggest VBP cord-005453-4057qib7 6815 10 that that IN cord-005453-4057qib7 6815 11 granulocytic granulocytic JJ cord-005453-4057qib7 6815 12 sarcoma sarcoma NN cord-005453-4057qib7 6815 13 cells cell NNS cord-005453-4057qib7 6815 14 were be VBD cord-005453-4057qib7 6815 15 dormant dormant JJ cord-005453-4057qib7 6815 16 but but CC cord-005453-4057qib7 6815 17 already already RB cord-005453-4057qib7 6815 18 present present JJ cord-005453-4057qib7 6815 19 at at IN cord-005453-4057qib7 6815 20 the the DT cord-005453-4057qib7 6815 21 time time NN cord-005453-4057qib7 6815 22 of of IN cord-005453-4057qib7 6815 23 pro pro JJ cord-005453-4057qib7 6815 24 - - JJ cord-005453-4057qib7 6815 25 B b JJ cord-005453-4057qib7 6815 26 ALL all DT cord-005453-4057qib7 6815 27 diagnosis diagnosis NN cord-005453-4057qib7 6815 28 and and CC cord-005453-4057qib7 6815 29 survived survive VBD cord-005453-4057qib7 6815 30 not not RB cord-005453-4057qib7 6815 31 only only RB cord-005453-4057qib7 6815 32 the the DT cord-005453-4057qib7 6815 33 initial initial JJ cord-005453-4057qib7 6815 34 ALL all DT cord-005453-4057qib7 6815 35 treatment treatment NN cord-005453-4057qib7 6815 36 but but CC cord-005453-4057qib7 6815 37 also also RB cord-005453-4057qib7 6815 38 the the DT cord-005453-4057qib7 6815 39 CB CB NNP cord-005453-4057qib7 6815 40 transplant transplant NN cord-005453-4057qib7 6815 41 conditioning conditioning NN cord-005453-4057qib7 6815 42 regimen regimen NN cord-005453-4057qib7 6815 43 . . . cord-005453-4057qib7 6816 1 We -PRON- PRP cord-005453-4057qib7 6816 2 ca can MD cord-005453-4057qib7 6816 3 n't not RB cord-005453-4057qib7 6816 4 exclude exclude VB cord-005453-4057qib7 6816 5 that that IN cord-005453-4057qib7 6816 6 immune immune JJ cord-005453-4057qib7 6816 7 - - HYPH cord-005453-4057qib7 6816 8 suppressive suppressive JJ cord-005453-4057qib7 6816 9 treatments treatment NNS cord-005453-4057qib7 6816 10 given give VBN cord-005453-4057qib7 6816 11 early early JJ cord-005453-4057qib7 6816 12 post post JJ cord-005453-4057qib7 6816 13 - - NN cord-005453-4057qib7 6816 14 transplant transplant NN cord-005453-4057qib7 6816 15 might may MD cord-005453-4057qib7 6816 16 have have VB cord-005453-4057qib7 6816 17 promoted promote VBN cord-005453-4057qib7 6816 18 the the DT cord-005453-4057qib7 6816 19 outgrowth outgrowth NN cord-005453-4057qib7 6816 20 of of IN cord-005453-4057qib7 6816 21 these these DT cord-005453-4057qib7 6816 22 neoplastic neoplastic JJ cord-005453-4057qib7 6816 23 cell cell NN cord-005453-4057qib7 6816 24 population population NN cord-005453-4057qib7 6816 25 . . . cord-005453-4057qib7 6817 1 Disclosure disclosure NN cord-005453-4057qib7 6817 2 : : : cord-005453-4057qib7 6817 3 Nothing nothing NN cord-005453-4057qib7 6817 4 to to TO cord-005453-4057qib7 6817 5 declare declare VB cord-005453-4057qib7 6817 6 Haemoglobinopathy Haemoglobinopathy NNP cord-005453-4057qib7 6817 7 and and CC cord-005453-4057qib7 6817 8 inborn inborn JJ cord-005453-4057qib7 6817 9 errors error NNS cord-005453-4057qib7 6817 10 of of IN cord-005453-4057qib7 6817 11 metabolism metabolism NN cord-005453-4057qib7 6817 12 P311 P311 NNP cord-005453-4057qib7 6817 13 Abstract Abstract NNP cord-005453-4057qib7 6817 14 already already RB cord-005453-4057qib7 6817 15 published publish VBN cord-005453-4057qib7 6817 16 . . . cord-005453-4057qib7 6818 1 Addition addition NN cord-005453-4057qib7 6818 2 of of IN cord-005453-4057qib7 6818 3 fludarabine fludarabine NN cord-005453-4057qib7 6818 4 on on IN cord-005453-4057qib7 6818 5 to to IN cord-005453-4057qib7 6818 6 anti anti JJ cord-005453-4057qib7 6818 7 - - JJ cord-005453-4057qib7 6818 8 thymocyte thymocyte JJ cord-005453-4057qib7 6818 9 globulin globulin NN cord-005453-4057qib7 6818 10 , , , cord-005453-4057qib7 6818 11 busulfan busulfan NN cord-005453-4057qib7 6818 12 and and CC cord-005453-4057qib7 6818 13 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 6818 14 conditioning conditioning NN cord-005453-4057qib7 6818 15 improves improve VBZ cord-005453-4057qib7 6818 16 outcomes outcome NNS cord-005453-4057qib7 6818 17 in in IN cord-005453-4057qib7 6818 18 low low JJ cord-005453-4057qib7 6818 19 - - HYPH cord-005453-4057qib7 6818 20 risk risk NN cord-005453-4057qib7 6818 21 matched match VBN cord-005453-4057qib7 6818 22 - - HYPH cord-005453-4057qib7 6818 23 related relate VBN cord-005453-4057qib7 6818 24 bone bone NN cord-005453-4057qib7 6818 25 marrow marrow NN cord-005453-4057qib7 6818 26 transplantation transplantation NN cord-005453-4057qib7 6818 27 in in IN cord-005453-4057qib7 6818 28 children child NNS cord-005453-4057qib7 6818 29 with with IN cord-005453-4057qib7 6818 30 severe severe JJ cord-005453-4057qib7 6818 31 thalassaemia thalassaemia NN cord-005453-4057qib7 6818 32 Flu Flu NNP cord-005453-4057qib7 6818 33 - - HYPH cord-005453-4057qib7 6818 34 ATG ATG NNP cord-005453-4057qib7 6818 35 - - HYPH cord-005453-4057qib7 6818 36 BuCy BuCy NNP cord-005453-4057qib7 6818 37 . . . cord-005453-4057qib7 6819 1 ATG ATG NNP cord-005453-4057qib7 6819 2 dose dose NN cord-005453-4057qib7 6819 3 was be VBD cord-005453-4057qib7 6819 4 4 4 CD cord-005453-4057qib7 6819 5 mg mg NNP cord-005453-4057qib7 6819 6 / / SYM cord-005453-4057qib7 6819 7 kg kg NNS cord-005453-4057qib7 6819 8 in in IN cord-005453-4057qib7 6819 9 all all DT cord-005453-4057qib7 6819 10 patients patient NNS cord-005453-4057qib7 6819 11 except except IN cord-005453-4057qib7 6819 12 patients patient NNS cord-005453-4057qib7 6819 13 with with IN cord-005453-4057qib7 6819 14 splenomegaly splenomegaly NN cord-005453-4057qib7 6819 15 > > XX cord-005453-4057qib7 6819 16 3 3 CD cord-005453-4057qib7 6819 17 cm cm NNS cord-005453-4057qib7 6819 18 from from IN cord-005453-4057qib7 6819 19 costal costal JJ cord-005453-4057qib7 6819 20 margin margin NNP cord-005453-4057qib7 6819 21 and/or and/or CC cord-005453-4057qib7 6819 22 sex sex NN cord-005453-4057qib7 6819 23 - - HYPH cord-005453-4057qib7 6819 24 mismatched mismatched JJ cord-005453-4057qib7 6819 25 / / SYM cord-005453-4057qib7 6819 26 maternal maternal JJ cord-005453-4057qib7 6819 27 donor donor NN cord-005453-4057qib7 6819 28 in in IN cord-005453-4057qib7 6819 29 whom whom WP cord-005453-4057qib7 6819 30 ATG ATG NNP cord-005453-4057qib7 6819 31 was be VBD cord-005453-4057qib7 6819 32 increased increase VBN cord-005453-4057qib7 6819 33 to to IN cord-005453-4057qib7 6819 34 7 7 CD cord-005453-4057qib7 6819 35 mg mg NNP cord-005453-4057qib7 6819 36 / / SYM cord-005453-4057qib7 6819 37 kg kg NNS cord-005453-4057qib7 6819 38 . . . cord-005453-4057qib7 6820 1 All all DT cord-005453-4057qib7 6820 2 patients patient NNS cord-005453-4057qib7 6820 3 were be VBD cord-005453-4057qib7 6820 4 younger young JJR cord-005453-4057qib7 6820 5 than than IN cord-005453-4057qib7 6820 6 15 15 CD cord-005453-4057qib7 6820 7 years year NNS cord-005453-4057qib7 6820 8 and and CC cord-005453-4057qib7 6820 9 had have VBD cord-005453-4057qib7 6820 10 no no DT cord-005453-4057qib7 6820 11 hepatomegaly hepatomegaly NNP cord-005453-4057qib7 6820 12 ( ( -LRB- cord-005453-4057qib7 6820 13 liver liver NNP cord-005453-4057qib7 6820 14 ≤ ≤ NNP cord-005453-4057qib7 6820 15 2 2 CD cord-005453-4057qib7 6820 16 cm cm NNP cord-005453-4057qib7 6820 17 from from IN cord-005453-4057qib7 6820 18 costal costal JJ cord-005453-4057qib7 6820 19 margin margin NNP cord-005453-4057qib7 6820 20 ) ) -RRB- cord-005453-4057qib7 6820 21 at at IN cord-005453-4057qib7 6820 22 BMT BMT NNP cord-005453-4057qib7 6820 23 . . . cord-005453-4057qib7 6821 1 Results result NNS cord-005453-4057qib7 6821 2 : : : cord-005453-4057qib7 6822 1 Actuarial actuarial JJ cord-005453-4057qib7 6822 2 overall overall JJ cord-005453-4057qib7 6822 3 survival survival NN cord-005453-4057qib7 6822 4 ( ( -LRB- cord-005453-4057qib7 6822 5 OS OS NNP cord-005453-4057qib7 6822 6 ) ) -RRB- cord-005453-4057qib7 6822 7 in in IN cord-005453-4057qib7 6822 8 the the DT cord-005453-4057qib7 6822 9 ATG ATG NNP cord-005453-4057qib7 6822 10 - - HYPH cord-005453-4057qib7 6822 11 BuCy BuCy NNP cord-005453-4057qib7 6822 12 and and CC cord-005453-4057qib7 6822 13 Flu Flu NNP cord-005453-4057qib7 6822 14 - - HYPH cord-005453-4057qib7 6822 15 ATG ATG NNP cord-005453-4057qib7 6822 16 - - HYPH cord-005453-4057qib7 6822 17 BuCy BuCy NNP cord-005453-4057qib7 6822 18 groups group NNS cord-005453-4057qib7 6822 19 is be VBZ cord-005453-4057qib7 6822 20 89 89 CD cord-005453-4057qib7 6822 21 % % NN cord-005453-4057qib7 6822 22 and and CC cord-005453-4057qib7 6822 23 98 98 CD cord-005453-4057qib7 6822 24 % % NN cord-005453-4057qib7 6822 25 , , , cord-005453-4057qib7 6822 26 thalassemia thalassemia NN cord-005453-4057qib7 6822 27 - - HYPH cord-005453-4057qib7 6822 28 free free JJ cord-005453-4057qib7 6822 29 survival survival NN cord-005453-4057qib7 6822 30 ( ( -LRB- cord-005453-4057qib7 6822 31 TFS TFS NNP cord-005453-4057qib7 6822 32 ) ) -RRB- cord-005453-4057qib7 6822 33 75 75 CD cord-005453-4057qib7 6822 34 % % NN cord-005453-4057qib7 6822 35 and and CC cord-005453-4057qib7 6822 36 93 93 CD cord-005453-4057qib7 6822 37 % % NN cord-005453-4057qib7 6822 38 , , , cord-005453-4057qib7 6822 39 GVHDfree GVHDfree NNP cord-005453-4057qib7 6822 40 and and CC cord-005453-4057qib7 6822 41 Thalassaemia Thalassaemia NNP cord-005453-4057qib7 6822 42 - - HYPH cord-005453-4057qib7 6822 43 free free JJ cord-005453-4057qib7 6822 44 survival survival NN cord-005453-4057qib7 6822 45 ( ( -LRB- cord-005453-4057qib7 6822 46 GTFS GTFS NNP cord-005453-4057qib7 6822 47 ) ) -RRB- cord-005453-4057qib7 6822 48 at at IN cord-005453-4057qib7 6822 49 a a DT cord-005453-4057qib7 6822 50 median median NN cord-005453-4057qib7 6822 51 follow follow NN cord-005453-4057qib7 6822 52 up up IN cord-005453-4057qib7 6822 53 of of IN cord-005453-4057qib7 6822 54 23.5 23.5 CD cord-005453-4057qib7 6822 55 and and CC cord-005453-4057qib7 6822 56 10.6 10.6 CD cord-005453-4057qib7 6822 57 months month NNS cord-005453-4057qib7 6822 58 was be VBD cord-005453-4057qib7 6822 59 72.6 72.6 CD cord-005453-4057qib7 6822 60 % % NN cord-005453-4057qib7 6822 61 and and CC cord-005453-4057qib7 6822 62 93.3 93.3 CD cord-005453-4057qib7 6822 63 % % NN cord-005453-4057qib7 6822 64 months month NNS cord-005453-4057qib7 6822 65 respectively respectively RB cord-005453-4057qib7 6822 66 , , , cord-005453-4057qib7 6822 67 which which WDT cord-005453-4057qib7 6822 68 is be VBZ cord-005453-4057qib7 6822 69 a a DT cord-005453-4057qib7 6822 70 significantly significantly RB cord-005453-4057qib7 6822 71 improved improve VBN cord-005453-4057qib7 6822 72 outcome outcome NN cord-005453-4057qib7 6822 73 by by IN cord-005453-4057qib7 6822 74 log log NN cord-005453-4057qib7 6822 75 - - HYPH cord-005453-4057qib7 6822 76 rank rank NN cord-005453-4057qib7 6822 77 statistics statistic NNS cord-005453-4057qib7 6822 78 ( ( -LRB- cord-005453-4057qib7 6822 79 p=0.002 p=0.002 NNP cord-005453-4057qib7 6822 80 ) ) -RRB- cord-005453-4057qib7 6823 1 in in IN cord-005453-4057qib7 6823 2 the the DT cord-005453-4057qib7 6823 3 Flu Flu NNP cord-005453-4057qib7 6823 4 - - HYPH cord-005453-4057qib7 6823 5 ATG ATG NNP cord-005453-4057qib7 6823 6 - - HYPH cord-005453-4057qib7 6823 7 BuCy BuCy NNP cord-005453-4057qib7 6823 8 group group NN cord-005453-4057qib7 6823 9 . . . cord-005453-4057qib7 6824 1 There there EX cord-005453-4057qib7 6824 2 was be VBD cord-005453-4057qib7 6824 3 no no DT cord-005453-4057qib7 6824 4 significant significant JJ cord-005453-4057qib7 6824 5 difference difference NN cord-005453-4057qib7 6824 6 between between IN cord-005453-4057qib7 6824 7 the the DT cord-005453-4057qib7 6824 8 groups group NNS cord-005453-4057qib7 6824 9 in in IN cord-005453-4057qib7 6824 10 pre pre JJ cord-005453-4057qib7 6824 11 - - JJ cord-005453-4057qib7 6824 12 transplant transplant JJ cord-005453-4057qib7 6824 13 characteristics characteristic NNS cord-005453-4057qib7 6824 14 and and CC cord-005453-4057qib7 6824 15 posttransplant posttransplant NN cord-005453-4057qib7 6824 16 complications complication NNS cord-005453-4057qib7 6824 17 except except IN cord-005453-4057qib7 6824 18 for for IN cord-005453-4057qib7 6824 19 the the DT cord-005453-4057qib7 6824 20 following follow VBG cord-005453-4057qib7 6824 21 : : : cord-005453-4057qib7 6824 22 Median median JJ cord-005453-4057qib7 6824 23 cell cell NN cord-005453-4057qib7 6824 24 dose dose NN cord-005453-4057qib7 6824 25 more more JJR cord-005453-4057qib7 6824 26 in in IN cord-005453-4057qib7 6824 27 2 2 CD cord-005453-4057qib7 6824 28 nd nd NNP cord-005453-4057qib7 6824 29 group group NN cord-005453-4057qib7 6824 30 with with IN cord-005453-4057qib7 6824 31 total total JJ cord-005453-4057qib7 6824 32 nucleated nucleated JJ cord-005453-4057qib7 6824 33 cell cell NN cord-005453-4057qib7 6824 34 dose dose NN cord-005453-4057qib7 6824 35 of of IN cord-005453-4057qib7 6824 36 8.7 8.7 CD cord-005453-4057qib7 6824 37 vs vs IN cord-005453-4057qib7 6824 38 6.4 6.4 CD cord-005453-4057qib7 6824 39 x x SYM cord-005453-4057qib7 6824 40 10 10 CD cord-005453-4057qib7 6824 41 8 8 CD cord-005453-4057qib7 6824 42 cell cell NN cord-005453-4057qib7 6824 43 / / SYM cord-005453-4057qib7 6824 44 kg kg NN cord-005453-4057qib7 6824 45 with with IN cord-005453-4057qib7 6824 46 p p NN cord-005453-4057qib7 6824 47 < < XX cord-005453-4057qib7 6824 48 0.0001 0.0001 CD cord-005453-4057qib7 6824 49 ; ; : cord-005453-4057qib7 6824 50 CSA CSA NNP cord-005453-4057qib7 6824 51 taper taper NN cord-005453-4057qib7 6824 52 started start VBD cord-005453-4057qib7 6824 53 later later RB cord-005453-4057qib7 6824 54 in in IN cord-005453-4057qib7 6824 55 the the DT cord-005453-4057qib7 6824 56 new new JJ cord-005453-4057qib7 6824 57 protocol protocol NN cord-005453-4057qib7 6824 58 ( ( -LRB- cord-005453-4057qib7 6824 59 184 184 CD cord-005453-4057qib7 6824 60 day day NN cord-005453-4057qib7 6824 61 vs. vs. IN cord-005453-4057qib7 6824 62 152 152 CD cord-005453-4057qib7 6824 63 p=0.0005 p=0.0005 NNS cord-005453-4057qib7 6824 64 ) ) -RRB- cord-005453-4057qib7 6824 65 ; ; : cord-005453-4057qib7 6824 66 Median median JJ cord-005453-4057qib7 6824 67 age age NN cord-005453-4057qib7 6824 68 at at IN cord-005453-4057qib7 6824 69 BMT BMT NNP cord-005453-4057qib7 6824 70 ( ( -LRB- cord-005453-4057qib7 6824 71 7.2 7.2 CD cord-005453-4057qib7 6824 72 vs. vs. IN cord-005453-4057qib7 6824 73 4.6 4.6 CD cord-005453-4057qib7 6824 74 years year NNS cord-005453-4057qib7 6824 75 , , , cord-005453-4057qib7 6824 76 p=0.001 p=0.001 NNP cord-005453-4057qib7 6824 77 ) ) -RRB- cord-005453-4057qib7 6824 78 ; ; : cord-005453-4057qib7 6825 1 Number number NN cord-005453-4057qib7 6825 2 of of IN cord-005453-4057qib7 6825 3 Pre Pre NNP cord-005453-4057qib7 6825 4 - - JJ cord-005453-4057qib7 6825 5 BMT BMT NNP cord-005453-4057qib7 6825 6 transfusions transfusion NNS cord-005453-4057qib7 6825 7 ( ( -LRB- cord-005453-4057qib7 6825 8 p=0.01 p=0.01 NNP cord-005453-4057qib7 6825 9 ) ) -RRB- cord-005453-4057qib7 6825 10 and and CC cord-005453-4057qib7 6825 11 Ferritin ferritin NN cord-005453-4057qib7 6825 12 at at IN cord-005453-4057qib7 6825 13 BMT BMT NNP cord-005453-4057qib7 6825 14 ( ( -LRB- cord-005453-4057qib7 6825 15 2.214 2.214 CD cord-005453-4057qib7 6825 16 vs. vs. NN cord-005453-4057qib7 6825 17 1.599 1.599 CD cord-005453-4057qib7 6825 18 ng ng NNP cord-005453-4057qib7 6825 19 / / SYM cord-005453-4057qib7 6825 20 mL mL NNP cord-005453-4057qib7 6825 21 , , , cord-005453-4057qib7 6825 22 p=0.002 p=0.002 NNP cord-005453-4057qib7 6825 23 ) ) -RRB- cord-005453-4057qib7 6825 24 were be VBD cord-005453-4057qib7 6825 25 higher high JJR cord-005453-4057qib7 6825 26 in in IN cord-005453-4057qib7 6825 27 the the DT cord-005453-4057qib7 6825 28 second second JJ cord-005453-4057qib7 6825 29 group group NN cord-005453-4057qib7 6825 30 ; ; : cord-005453-4057qib7 6825 31 Day day NN cord-005453-4057qib7 6825 32 30 30 CD cord-005453-4057qib7 6825 33 and and CC cord-005453-4057qib7 6825 34 60 60 CD cord-005453-4057qib7 6825 35 chimerisms chimerism NNS cord-005453-4057qib7 6825 36 were be VBD cord-005453-4057qib7 6825 37 also also RB cord-005453-4057qib7 6825 38 significantly significantly RB cord-005453-4057qib7 6825 39 higher high JJR cord-005453-4057qib7 6825 40 in in IN cord-005453-4057qib7 6825 41 new new JJ cord-005453-4057qib7 6825 42 protocol protocol NN cord-005453-4057qib7 6825 43 ( ( -LRB- cord-005453-4057qib7 6825 44 p=0.02 p=0.02 NN cord-005453-4057qib7 6825 45 and and CC cord-005453-4057qib7 6825 46 0.03 0.03 CD cord-005453-4057qib7 6825 47 respectively respectively RB cord-005453-4057qib7 6825 48 ) ) -RRB- cord-005453-4057qib7 6825 49 . . . cord-005453-4057qib7 6826 1 There there EX cord-005453-4057qib7 6826 2 was be VBD cord-005453-4057qib7 6826 3 a a DT cord-005453-4057qib7 6826 4 trend trend NN cord-005453-4057qib7 6826 5 towards towards IN cord-005453-4057qib7 6826 6 increased increase VBN cord-005453-4057qib7 6826 7 incidence incidence NN cord-005453-4057qib7 6826 8 of of IN cord-005453-4057qib7 6826 9 Veno Veno NNP cord-005453-4057qib7 6826 10 - - HYPH cord-005453-4057qib7 6826 11 Occulsive Occulsive NNP cord-005453-4057qib7 6826 12 Disease Disease NNP cord-005453-4057qib7 6826 13 ( ( -LRB- cord-005453-4057qib7 6826 14 VOD VOD NNP cord-005453-4057qib7 6826 15 ) ) -RRB- cord-005453-4057qib7 6826 16 and and CC cord-005453-4057qib7 6826 17 Posterior Posterior NNP cord-005453-4057qib7 6826 18 Reversible Reversible NNP cord-005453-4057qib7 6826 19 Encephalopathy Encephalopathy NNP cord-005453-4057qib7 6826 20 Syndrome Syndrome NNP cord-005453-4057qib7 6826 21 ( ( -LRB- cord-005453-4057qib7 6826 22 PRES PRES NNP cord-005453-4057qib7 6826 23 ) ) -RRB- cord-005453-4057qib7 6826 24 on on IN cord-005453-4057qib7 6826 25 the the DT cord-005453-4057qib7 6826 26 second second JJ cord-005453-4057qib7 6826 27 group group NN cord-005453-4057qib7 6827 1 but but CC cord-005453-4057qib7 6827 2 this this DT cord-005453-4057qib7 6827 3 difference difference NN cord-005453-4057qib7 6827 4 did do VBD cord-005453-4057qib7 6827 5 not not RB cord-005453-4057qib7 6827 6 reach reach VB cord-005453-4057qib7 6827 7 statistical statistical JJ cord-005453-4057qib7 6827 8 significance significance NN cord-005453-4057qib7 6827 9 . . . cord-005453-4057qib7 6828 1 Conclusions conclusion NNS cord-005453-4057qib7 6828 2 : : : cord-005453-4057qib7 6829 1 Adding add VBG cord-005453-4057qib7 6829 2 Fludarabine Fludarabine NNP cord-005453-4057qib7 6829 3 and and CC cord-005453-4057qib7 6829 4 targeted target VBN cord-005453-4057qib7 6829 5 dose dose JJ cord-005453-4057qib7 6829 6 increase increase NN cord-005453-4057qib7 6829 7 of of IN cord-005453-4057qib7 6829 8 ATG ATG NNP cord-005453-4057qib7 6829 9 in in IN cord-005453-4057qib7 6829 10 the the DT cord-005453-4057qib7 6829 11 standard standard JJ cord-005453-4057qib7 6829 12 BuCy BuCy NNP cord-005453-4057qib7 6829 13 context context NN cord-005453-4057qib7 6829 14 seems seem VBZ cord-005453-4057qib7 6829 15 to to TO cord-005453-4057qib7 6829 16 significantly significantly RB cord-005453-4057qib7 6829 17 improve improve VB cord-005453-4057qib7 6829 18 outcomes outcome NNS cord-005453-4057qib7 6829 19 of of IN cord-005453-4057qib7 6829 20 thalassaemia thalassaemia NN cord-005453-4057qib7 6829 21 transplants transplant NNS cord-005453-4057qib7 6829 22 without without IN cord-005453-4057qib7 6829 23 contributing contribute VBG cord-005453-4057qib7 6829 24 to to IN cord-005453-4057qib7 6829 25 excessive excessive JJ cord-005453-4057qib7 6829 26 GVHD GVHD NNP cord-005453-4057qib7 6829 27 or or CC cord-005453-4057qib7 6829 28 infectious infectious JJ cord-005453-4057qib7 6829 29 complications complication NNS cord-005453-4057qib7 6829 30 . . . cord-005453-4057qib7 6830 1 This this DT cord-005453-4057qib7 6830 2 protocol protocol NN cord-005453-4057qib7 6830 3 can can MD cord-005453-4057qib7 6830 4 be be VB cord-005453-4057qib7 6830 5 easily easily RB cord-005453-4057qib7 6830 6 administered administer VBN cord-005453-4057qib7 6830 7 in in IN cord-005453-4057qib7 6830 8 low low JJ cord-005453-4057qib7 6830 9 resource resource NN cord-005453-4057qib7 6830 10 setting set VBG cord-005453-4057qib7 6830 11 without without IN cord-005453-4057qib7 6830 12 major major JJ cord-005453-4057qib7 6830 13 additional additional JJ cord-005453-4057qib7 6830 14 costs cost NNS cord-005453-4057qib7 6830 15 . . . cord-005453-4057qib7 6831 1 Clinical clinical JJ cord-005453-4057qib7 6831 2 is be VBZ cord-005453-4057qib7 6831 3 an an DT cord-005453-4057qib7 6831 4 acquired acquire VBN cord-005453-4057qib7 6831 5 clonal clonal JJ cord-005453-4057qib7 6831 6 disorder disorder NN cord-005453-4057qib7 6831 7 of of IN cord-005453-4057qib7 6831 8 the the DT cord-005453-4057qib7 6831 9 hemopoietic hemopoietic JJ cord-005453-4057qib7 6831 10 stem stem NN cord-005453-4057qib7 6831 11 cells cell NNS cord-005453-4057qib7 6831 12 for for IN cord-005453-4057qib7 6831 13 which which WDT cord-005453-4057qib7 6831 14 the the DT cord-005453-4057qib7 6831 15 only only JJ cord-005453-4057qib7 6831 16 curative curative JJ cord-005453-4057qib7 6831 17 treatment treatment NN cord-005453-4057qib7 6831 18 is be VBZ cord-005453-4057qib7 6831 19 allogeneic allogeneic VBG cord-005453-4057qib7 6831 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 6831 21 stem stem NN cord-005453-4057qib7 6831 22 cell cell NN cord-005453-4057qib7 6831 23 transplantation transplantation NN cord-005453-4057qib7 6831 24 . . . cord-005453-4057qib7 6832 1 However however RB cord-005453-4057qib7 6832 2 , , , cord-005453-4057qib7 6832 3 there there EX cord-005453-4057qib7 6832 4 are be VBP cord-005453-4057qib7 6832 5 still still RB cord-005453-4057qib7 6832 6 few few JJ cord-005453-4057qib7 6832 7 reports report NNS cord-005453-4057qib7 6832 8 on on IN cord-005453-4057qib7 6832 9 the the DT cord-005453-4057qib7 6832 10 outcomes outcome NNS cord-005453-4057qib7 6832 11 of of IN cord-005453-4057qib7 6832 12 allogeneic allogeneic JJ cord-005453-4057qib7 6832 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 6832 14 stem stem NN cord-005453-4057qib7 6832 15 cell cell NN cord-005453-4057qib7 6832 16 transplantation transplantation NN cord-005453-4057qib7 6832 17 ( ( -LRB- cord-005453-4057qib7 6832 18 allo allo NN cord-005453-4057qib7 6832 19 - - HYPH cord-005453-4057qib7 6832 20 HSCT HSCT NNP cord-005453-4057qib7 6832 21 ) ) -RRB- cord-005453-4057qib7 6832 22 in in IN cord-005453-4057qib7 6832 23 patients patient NNS cord-005453-4057qib7 6832 24 with with IN cord-005453-4057qib7 6832 25 PNH PNH NNP cord-005453-4057qib7 6832 26 compared compare VBN cord-005453-4057qib7 6832 27 to to IN cord-005453-4057qib7 6832 28 paroxysmal paroxysmal JJ cord-005453-4057qib7 6832 29 nocturnal nocturnal JJ cord-005453-4057qib7 6832 30 hemoglobinuria hemoglobinuria NN cord-005453-4057qib7 6832 31 - - HYPH cord-005453-4057qib7 6832 32 aplastic aplastic JJ cord-005453-4057qib7 6832 33 anemia anemia NN cord-005453-4057qib7 6832 34 ( ( -LRB- cord-005453-4057qib7 6832 35 PNH PNH NNP cord-005453-4057qib7 6832 36 - - HYPH cord-005453-4057qib7 6832 37 AA AA NNP cord-005453-4057qib7 6832 38 ) ) -RRB- cord-005453-4057qib7 6832 39 syndrome syndrome NN cord-005453-4057qib7 6832 40 . . . cord-005453-4057qib7 6833 1 Our -PRON- PRP$ cord-005453-4057qib7 6833 2 study study NN cord-005453-4057qib7 6833 3 aimed aim VBD cord-005453-4057qib7 6833 4 to to TO cord-005453-4057qib7 6833 5 compare compare VB cord-005453-4057qib7 6833 6 the the DT cord-005453-4057qib7 6833 7 outcomes outcome NNS cord-005453-4057qib7 6833 8 of of IN cord-005453-4057qib7 6833 9 allo allo NN cord-005453-4057qib7 6833 10 - - HYPH cord-005453-4057qib7 6833 11 HSCT HSCT NNP cord-005453-4057qib7 6833 12 for for IN cord-005453-4057qib7 6833 13 PNH PNH NNP cord-005453-4057qib7 6833 14 with with IN cord-005453-4057qib7 6833 15 PNH PNH NNP cord-005453-4057qib7 6833 16 - - HYPH cord-005453-4057qib7 6833 17 AA AA NNP cord-005453-4057qib7 6833 18 syndrome syndrome NN cord-005453-4057qib7 6833 19 . . . cord-005453-4057qib7 6834 1 Methods method NNS cord-005453-4057qib7 6834 2 : : : cord-005453-4057qib7 6835 1 The the DT cord-005453-4057qib7 6835 2 clinical clinical JJ cord-005453-4057qib7 6835 3 data datum NNS cord-005453-4057qib7 6835 4 of of IN cord-005453-4057qib7 6835 5 46 46 CD cord-005453-4057qib7 6835 6 PNH PNH NNP cord-005453-4057qib7 6835 7 patients patient NNS cord-005453-4057qib7 6835 8 received receive VBD cord-005453-4057qib7 6835 9 allo allo NN cord-005453-4057qib7 6835 10 - - HYPH cord-005453-4057qib7 6835 11 HSCT HSCT NNP cord-005453-4057qib7 6835 12 ( ( -LRB- cord-005453-4057qib7 6835 13 PNH PNH NNP cord-005453-4057qib7 6835 14 = = SYM cord-005453-4057qib7 6835 15 16 16 CD cord-005453-4057qib7 6835 16 , , , cord-005453-4057qib7 6835 17 PNH PNH NNP cord-005453-4057qib7 6835 18 - - HYPH cord-005453-4057qib7 6835 19 AA AA NNP cord-005453-4057qib7 6835 20 = = SYM cord-005453-4057qib7 6835 21 30 30 CD cord-005453-4057qib7 6835 22 ) ) -RRB- cord-005453-4057qib7 6835 23 in in IN cord-005453-4057qib7 6835 24 our -PRON- PRP$ cord-005453-4057qib7 6835 25 center center NN cord-005453-4057qib7 6835 26 from from IN cord-005453-4057qib7 6835 27 July July NNP cord-005453-4057qib7 6835 28 2007 2007 CD cord-005453-4057qib7 6835 29 to to IN cord-005453-4057qib7 6835 30 June June NNP cord-005453-4057qib7 6835 31 2018 2018 CD cord-005453-4057qib7 6835 32 were be VBD cord-005453-4057qib7 6835 33 analyzed analyze VBN cord-005453-4057qib7 6835 34 retrospectively retrospectively RB cord-005453-4057qib7 6835 35 to to TO cord-005453-4057qib7 6835 36 compare compare VB cord-005453-4057qib7 6835 37 the the DT cord-005453-4057qib7 6835 38 outcomes outcome NNS cord-005453-4057qib7 6835 39 of of IN cord-005453-4057qib7 6835 40 PNH PNH NNP cord-005453-4057qib7 6835 41 group group NN cord-005453-4057qib7 6835 42 with with IN cord-005453-4057qib7 6835 43 PNH PNH NNP cord-005453-4057qib7 6835 44 - - HYPH cord-005453-4057qib7 6835 45 AA AA NNP cord-005453-4057qib7 6835 46 group group NN cord-005453-4057qib7 6835 47 . . . cord-005453-4057qib7 6836 1 The the DT cord-005453-4057qib7 6836 2 clinical clinical JJ cord-005453-4057qib7 6836 3 data datum NNS cord-005453-4057qib7 6836 4 including include VBG cord-005453-4057qib7 6836 5 28 28 CD cord-005453-4057qib7 6836 6 male male JJ cord-005453-4057qib7 6836 7 patients patient NNS cord-005453-4057qib7 6836 8 and and CC cord-005453-4057qib7 6836 9 18 18 CD cord-005453-4057qib7 6836 10 female female JJ cord-005453-4057qib7 6836 11 patients patient NNS cord-005453-4057qib7 6836 12 , , , cord-005453-4057qib7 6836 13 the the DT cord-005453-4057qib7 6836 14 median median JJ cord-005453-4057qib7 6836 15 age age NN cord-005453-4057qib7 6836 16 was be VBD cord-005453-4057qib7 6836 17 29 29 CD cord-005453-4057qib7 6836 18 years year NNS cord-005453-4057qib7 6837 1 ( ( -LRB- cord-005453-4057qib7 6837 2 range range NNP cord-005453-4057qib7 6837 3 6 6 CD cord-005453-4057qib7 6837 4 - - SYM cord-005453-4057qib7 6837 5 54 54 CD cord-005453-4057qib7 6837 6 ) ) -RRB- cord-005453-4057qib7 6837 7 . . . cord-005453-4057qib7 6838 1 All all DT cord-005453-4057qib7 6838 2 patients patient NNS cord-005453-4057qib7 6838 3 had have VBD cord-005453-4057qib7 6838 4 received receive VBN cord-005453-4057qib7 6838 5 various various JJ cord-005453-4057qib7 6838 6 treatments treatment NNS cord-005453-4057qib7 6838 7 before before IN cord-005453-4057qib7 6838 8 transplantation transplantation NN cord-005453-4057qib7 6838 9 such such JJ cord-005453-4057qib7 6838 10 as as IN cord-005453-4057qib7 6838 11 steroids steroid NNS cord-005453-4057qib7 6838 12 , , , cord-005453-4057qib7 6838 13 androgens androgen NNS cord-005453-4057qib7 6838 14 , , , cord-005453-4057qib7 6838 15 cyclosporine cyclosporine NN cord-005453-4057qib7 6838 16 ( ( -LRB- cord-005453-4057qib7 6838 17 CsA CsA NNP cord-005453-4057qib7 6838 18 ) ) -RRB- cord-005453-4057qib7 6838 19 , , , cord-005453-4057qib7 6838 20 antithymocyte antithymocyte NNP cord-005453-4057qib7 6838 21 globulin globulin NN cord-005453-4057qib7 6838 22 , , , cord-005453-4057qib7 6838 23 and and CC cord-005453-4057qib7 6838 24 growth growth NN cord-005453-4057qib7 6838 25 factors factor NNS cord-005453-4057qib7 6838 26 . . . cord-005453-4057qib7 6839 1 The the DT cord-005453-4057qib7 6839 2 median median JJ cord-005453-4057qib7 6839 3 interval interval NN cord-005453-4057qib7 6839 4 from from IN cord-005453-4057qib7 6839 5 PNH PNH NNP cord-005453-4057qib7 6839 6 diagnosis diagnosis NN cord-005453-4057qib7 6839 7 to to IN cord-005453-4057qib7 6839 8 HSCT HSCT NNP cord-005453-4057qib7 6839 9 was be VBD cord-005453-4057qib7 6839 10 6 6 CD cord-005453-4057qib7 6839 11 months month NNS cord-005453-4057qib7 6840 1 ( ( -LRB- cord-005453-4057qib7 6840 2 range range NNP cord-005453-4057qib7 6840 3 3 3 CD cord-005453-4057qib7 6840 4 - - SYM cord-005453-4057qib7 6840 5 240 240 CD cord-005453-4057qib7 6840 6 ) ) -RRB- cord-005453-4057qib7 6840 7 . . . cord-005453-4057qib7 6841 1 The the DT cord-005453-4057qib7 6841 2 conditioning conditioning NN cord-005453-4057qib7 6841 3 regimen regimen NN cord-005453-4057qib7 6841 4 was be VBD cord-005453-4057qib7 6841 5 modified modify VBN cord-005453-4057qib7 6841 6 BU BU NNP cord-005453-4057qib7 6841 7 / / SYM cord-005453-4057qib7 6841 8 CYbased cybase VBN cord-005453-4057qib7 6841 9 regimen regimen NN cord-005453-4057qib7 6841 10 in in IN cord-005453-4057qib7 6841 11 haploidentical haploidentical JJ cord-005453-4057qib7 6841 12 donors donor NNS cord-005453-4057qib7 6841 13 and and CC cord-005453-4057qib7 6841 14 unrelated unrelated JJ cord-005453-4057qib7 6841 15 donors donor NNS cord-005453-4057qib7 6841 16 , , , cord-005453-4057qib7 6841 17 CsA CsA NNP cord-005453-4057qib7 6841 18 , , , cord-005453-4057qib7 6841 19 mycophenolate mycophenolate NNP cord-005453-4057qib7 6841 20 mofetil mofetil NNP cord-005453-4057qib7 6841 21 ( ( -LRB- cord-005453-4057qib7 6841 22 MMF MMF NNP cord-005453-4057qib7 6841 23 ) ) -RRB- cord-005453-4057qib7 6841 24 and and CC cord-005453-4057qib7 6841 25 shortterm shortterm JJ cord-005453-4057qib7 6841 26 methotrexate methotrexate NNP cord-005453-4057qib7 6841 27 ( ( -LRB- cord-005453-4057qib7 6841 28 MTX MTX NNP cord-005453-4057qib7 6841 29 ) ) -RRB- cord-005453-4057qib7 6841 30 were be VBD cord-005453-4057qib7 6841 31 administered administer VBN cord-005453-4057qib7 6841 32 for for IN cord-005453-4057qib7 6841 33 graftversus graftversus NNP cord-005453-4057qib7 6841 34 host host NN cord-005453-4057qib7 6841 35 disease disease NN cord-005453-4057qib7 6841 36 ( ( -LRB- cord-005453-4057qib7 6841 37 GVHD GVHD NNP cord-005453-4057qib7 6841 38 ) ) -RRB- cord-005453-4057qib7 6841 39 prophylaxis prophylaxis NN cord-005453-4057qib7 6841 40 . . . cord-005453-4057qib7 6842 1 Patients patient NNS cord-005453-4057qib7 6842 2 with with IN cord-005453-4057qib7 6842 3 matched match VBN cord-005453-4057qib7 6842 4 sibling sibling NN cord-005453-4057qib7 6842 5 donors donor NNS cord-005453-4057qib7 6842 6 were be VBD cord-005453-4057qib7 6842 7 treated treat VBN cord-005453-4057qib7 6842 8 with with IN cord-005453-4057qib7 6842 9 the the DT cord-005453-4057qib7 6842 10 FLU FLU NNP cord-005453-4057qib7 6842 11 / / SYM cord-005453-4057qib7 6842 12 CYbased cybase VBN cord-005453-4057qib7 6842 13 regimen regimen NN cord-005453-4057qib7 6842 14 and and CC cord-005453-4057qib7 6842 15 CsA CsA NNP cord-005453-4057qib7 6842 16 were be VBD cord-005453-4057qib7 6842 17 administered administer VBN cord-005453-4057qib7 6842 18 for for IN cord-005453-4057qib7 6842 19 GVHD GVHD NNP cord-005453-4057qib7 6842 20 prophylaxis prophylaxis NN cord-005453-4057qib7 6842 21 . . . cord-005453-4057qib7 6843 1 Results result NNS cord-005453-4057qib7 6843 2 : : : cord-005453-4057qib7 6844 1 There there EX cord-005453-4057qib7 6844 2 were be VBD cord-005453-4057qib7 6844 3 no no DT cord-005453-4057qib7 6844 4 differences difference NNS cord-005453-4057qib7 6844 5 of of IN cord-005453-4057qib7 6844 6 baseline baseline NN cord-005453-4057qib7 6844 7 between between IN cord-005453-4057qib7 6844 8 the the DT cord-005453-4057qib7 6844 9 2 2 CD cord-005453-4057qib7 6844 10 groups group NNS cord-005453-4057qib7 6844 11 ( ( -LRB- cord-005453-4057qib7 6844 12 P>0.05 P>0.05 NNP cord-005453-4057qib7 6844 13 ) ) -RRB- cord-005453-4057qib7 6844 14 except except IN cord-005453-4057qib7 6844 15 gender gender NN cord-005453-4057qib7 6844 16 and and CC cord-005453-4057qib7 6844 17 haploidentical haploidentical JJ cord-005453-4057qib7 6844 18 donors donor NNS cord-005453-4057qib7 6844 19 . . . cord-005453-4057qib7 6845 1 The the DT cord-005453-4057qib7 6845 2 median median JJ cord-005453-4057qib7 6845 3 values value NNS cord-005453-4057qib7 6845 4 of of IN cord-005453-4057qib7 6845 5 absolute absolute JJ cord-005453-4057qib7 6845 6 nucleated nucleated JJ cord-005453-4057qib7 6845 7 cell cell NN cord-005453-4057qib7 6845 8 counts count NNS cord-005453-4057qib7 6845 9 were be VBD cord-005453-4057qib7 6845 10 10.58 10.58 CD cord-005453-4057qib7 6845 11 ( ( -LRB- cord-005453-4057qib7 6845 12 3.83 3.83 CD cord-005453-4057qib7 6845 13 - - SYM cord-005453-4057qib7 6845 14 13.83 13.83 CD cord-005453-4057qib7 6845 15 ) ) -RRB- cord-005453-4057qib7 6846 1 ×10 ×10 NNS cord-005453-4057qib7 6846 2 8 8 CD cord-005453-4057qib7 6847 1 /kg /kg NFP cord-005453-4057qib7 6847 2 in in IN cord-005453-4057qib7 6847 3 the the DT cord-005453-4057qib7 6847 4 PNH PNH NNP cord-005453-4057qib7 6847 5 group group NN cord-005453-4057qib7 6847 6 and and CC cord-005453-4057qib7 6847 7 10.81 10.81 CD cord-005453-4057qib7 6847 8 ( ( -LRB- cord-005453-4057qib7 6847 9 3.96 3.96 CD cord-005453-4057qib7 6847 10 - - SYM cord-005453-4057qib7 6847 11 33.40 33.40 CD cord-005453-4057qib7 6847 12 ) ) -RRB- cord-005453-4057qib7 6848 1 ×10 ×10 NNS cord-005453-4057qib7 6848 2 8 8 CD cord-005453-4057qib7 6849 1 /kg /kg NFP cord-005453-4057qib7 6849 2 in in IN cord-005453-4057qib7 6849 3 the the DT cord-005453-4057qib7 6849 4 PNH PNH NNP cord-005453-4057qib7 6849 5 - - HYPH cord-005453-4057qib7 6849 6 AA AA NNP cord-005453-4057qib7 6849 7 group group NN cord-005453-4057qib7 6849 8 ( ( -LRB- cord-005453-4057qib7 6849 9 P p NN cord-005453-4057qib7 6849 10 = = SYM cord-005453-4057qib7 6849 11 0.668 0.668 CD cord-005453-4057qib7 6849 12 ) ) -RRB- cord-005453-4057qib7 6849 13 . . . cord-005453-4057qib7 6850 1 The the DT cord-005453-4057qib7 6850 2 median median JJ cord-005453-4057qib7 6850 3 doses dose NNS cord-005453-4057qib7 6850 4 of of IN cord-005453-4057qib7 6850 5 CD34 CD34 NNP cord-005453-4057qib7 6850 6 + + CC cord-005453-4057qib7 6850 7 cells cell NNS cord-005453-4057qib7 6850 8 infused infuse VBN cord-005453-4057qib7 6850 9 were be VBD cord-005453-4057qib7 6850 10 5.00 5.00 CD cord-005453-4057qib7 6850 11 ( ( -LRB- cord-005453-4057qib7 6850 12 3.14 3.14 CD cord-005453-4057qib7 6850 13 - - SYM cord-005453-4057qib7 6850 14 8.42)×10 8.42)×10 CD cord-005453-4057qib7 6850 15 6 6 CD cord-005453-4057qib7 6850 16 /kg /kg NFP cord-005453-4057qib7 6850 17 and and CC cord-005453-4057qib7 6850 18 3.57 3.57 CD cord-005453-4057qib7 6850 19 ( ( -LRB- cord-005453-4057qib7 6850 20 1.97 1.97 CD cord-005453-4057qib7 6850 21 - - SYM cord-005453-4057qib7 6850 22 6.17)×10 6.17)×10 CD cord-005453-4057qib7 6850 23 6 6 CD cord-005453-4057qib7 6851 1 /kg /kg NFP cord-005453-4057qib7 6851 2 ( ( -LRB- cord-005453-4057qib7 6851 3 P p NN cord-005453-4057qib7 6851 4 = = SYM cord-005453-4057qib7 6851 5 0.002 0.002 CD cord-005453-4057qib7 6851 6 ) ) -RRB- cord-005453-4057qib7 6851 7 , , , cord-005453-4057qib7 6851 8 respectively respectively RB cord-005453-4057qib7 6851 9 . . . cord-005453-4057qib7 6852 1 All all DT cord-005453-4057qib7 6852 2 patients patient NNS cord-005453-4057qib7 6852 3 attained attain VBD cord-005453-4057qib7 6852 4 complete complete JJ cord-005453-4057qib7 6852 5 engraftment engraftment NN cord-005453-4057qib7 6852 6 , , , cord-005453-4057qib7 6852 7 no no DT cord-005453-4057qib7 6852 8 patient patient NN cord-005453-4057qib7 6852 9 occurred occur VBD cord-005453-4057qib7 6852 10 graft graft NN cord-005453-4057qib7 6852 11 failure failure NN cord-005453-4057qib7 6852 12 . . . cord-005453-4057qib7 6853 1 The the DT cord-005453-4057qib7 6853 2 median median JJ cord-005453-4057qib7 6853 3 time time NN cord-005453-4057qib7 6853 4 for for IN cord-005453-4057qib7 6853 5 myeloid myeloid NN cord-005453-4057qib7 6853 6 engraftment engraftment NN cord-005453-4057qib7 6853 7 were be VBD cord-005453-4057qib7 6853 8 11 11 CD cord-005453-4057qib7 6854 1 ( ( -LRB- cord-005453-4057qib7 6854 2 range range NN cord-005453-4057qib7 6854 3 , , , cord-005453-4057qib7 6854 4 7 7 CD cord-005453-4057qib7 6854 5 - - SYM cord-005453-4057qib7 6854 6 14 14 CD cord-005453-4057qib7 6854 7 ) ) -RRB- cord-005453-4057qib7 6854 8 days day NNS cord-005453-4057qib7 6854 9 in in IN cord-005453-4057qib7 6854 10 the the DT cord-005453-4057qib7 6854 11 PNH PNH NNP cord-005453-4057qib7 6854 12 group group NN cord-005453-4057qib7 6854 13 and and CC cord-005453-4057qib7 6854 14 12 12 CD cord-005453-4057qib7 6854 15 ( ( -LRB- cord-005453-4057qib7 6854 16 range range NN cord-005453-4057qib7 6854 17 , , , cord-005453-4057qib7 6854 18 10 10 CD cord-005453-4057qib7 6854 19 - - SYM cord-005453-4057qib7 6854 20 26 26 CD cord-005453-4057qib7 6854 21 ) ) -RRB- cord-005453-4057qib7 6854 22 days day NNS cord-005453-4057qib7 6854 23 in in IN cord-005453-4057qib7 6854 24 the the DT cord-005453-4057qib7 6854 25 PNH PNH NNP cord-005453-4057qib7 6854 26 - - HYPH cord-005453-4057qib7 6854 27 AA AA NNP cord-005453-4057qib7 6854 28 group group NN cord-005453-4057qib7 6854 29 ( ( -LRB- cord-005453-4057qib7 6854 30 P p NN cord-005453-4057qib7 6854 31 = = SYM cord-005453-4057qib7 6854 32 0.003 0.003 CD cord-005453-4057qib7 6854 33 ) ) -RRB- cord-005453-4057qib7 6854 34 . . . cord-005453-4057qib7 6855 1 The the DT cord-005453-4057qib7 6855 2 median median JJ cord-005453-4057qib7 6855 3 time time NN cord-005453-4057qib7 6855 4 for for IN cord-005453-4057qib7 6855 5 platelet platelet NN cord-005453-4057qib7 6855 6 engraftment engraftment NN cord-005453-4057qib7 6855 7 were be VBD cord-005453-4057qib7 6855 8 13 13 CD cord-005453-4057qib7 6856 1 ( ( -LRB- cord-005453-4057qib7 6856 2 range range NN cord-005453-4057qib7 6856 3 , , , cord-005453-4057qib7 6856 4 11 11 CD cord-005453-4057qib7 6856 5 - - SYM cord-005453-4057qib7 6856 6 16 16 CD cord-005453-4057qib7 6856 7 ) ) -RRB- cord-005453-4057qib7 6856 8 days day NNS cord-005453-4057qib7 6856 9 and and CC cord-005453-4057qib7 6856 10 18 18 CD cord-005453-4057qib7 6857 1 ( ( -LRB- cord-005453-4057qib7 6857 2 range range NN cord-005453-4057qib7 6857 3 , , , cord-005453-4057qib7 6857 4 12 12 CD cord-005453-4057qib7 6857 5 - - SYM cord-005453-4057qib7 6857 6 75 75 CD cord-005453-4057qib7 6857 7 ) ) -RRB- cord-005453-4057qib7 6857 8 days day NNS cord-005453-4057qib7 6857 9 ( ( -LRB- cord-005453-4057qib7 6857 10 P p NN cord-005453-4057qib7 6857 11 = = SYM cord-005453-4057qib7 6857 12 0.002 0.002 CD cord-005453-4057qib7 6857 13 ) ) -RRB- cord-005453-4057qib7 6857 14 , , , cord-005453-4057qib7 6857 15 respectively respectively RB cord-005453-4057qib7 6857 16 . . . cord-005453-4057qib7 6858 1 With with IN cord-005453-4057qib7 6858 2 a a DT cord-005453-4057qib7 6858 3 median median JJ cord-005453-4057qib7 6858 4 follow follow NN cord-005453-4057qib7 6858 5 - - HYPH cord-005453-4057qib7 6858 6 up up NN cord-005453-4057qib7 6858 7 of of IN cord-005453-4057qib7 6858 8 36 36 CD cord-005453-4057qib7 6858 9 ( ( -LRB- cord-005453-4057qib7 6858 10 4 4 CD cord-005453-4057qib7 6858 11 - - SYM cord-005453-4057qib7 6858 12 132 132 CD cord-005453-4057qib7 6858 13 ) ) -RRB- cord-005453-4057qib7 6858 14 months month NNS cord-005453-4057qib7 6858 15 in in IN cord-005453-4057qib7 6858 16 the the DT cord-005453-4057qib7 6858 17 PNH PNH NNP cord-005453-4057qib7 6858 18 group group NN cord-005453-4057qib7 6858 19 and and CC cord-005453-4057qib7 6858 20 26 26 CD cord-005453-4057qib7 6858 21 ( ( -LRB- cord-005453-4057qib7 6858 22 4 4 CD cord-005453-4057qib7 6858 23 - - SYM cord-005453-4057qib7 6858 24 75 75 CD cord-005453-4057qib7 6858 25 ) ) -RRB- cord-005453-4057qib7 6858 26 months month NNS cord-005453-4057qib7 6858 27 in in IN cord-005453-4057qib7 6858 28 the the DT cord-005453-4057qib7 6858 29 PNH PNH NNP cord-005453-4057qib7 6858 30 - - HYPH cord-005453-4057qib7 6858 31 AA AA NNP cord-005453-4057qib7 6858 32 group group NN cord-005453-4057qib7 6858 33 ( ( -LRB- cord-005453-4057qib7 6858 34 P p NN cord-005453-4057qib7 6858 35 = = SYM cord-005453-4057qib7 6858 36 0.428 0.428 CD cord-005453-4057qib7 6858 37 ) ) -RRB- cord-005453-4057qib7 6858 38 . . . cord-005453-4057qib7 6859 1 In in IN cord-005453-4057qib7 6859 2 PNH PNH NNP cord-005453-4057qib7 6859 3 and and CC cord-005453-4057qib7 6859 4 PNH PNH NNP cord-005453-4057qib7 6859 5 - - HYPH cord-005453-4057qib7 6859 6 AA AA NNP cord-005453-4057qib7 6859 7 groups group NNS cord-005453-4057qib7 6859 8 the the DT cord-005453-4057qib7 6859 9 incidences incidence NNS cord-005453-4057qib7 6859 10 of of IN cord-005453-4057qib7 6859 11 grade grade NN cord-005453-4057qib7 6859 12 I I NNP cord-005453-4057qib7 6859 13 - - HYPH cord-005453-4057qib7 6859 14 IV IV NNP cord-005453-4057qib7 6859 15 acute acute JJ cord-005453-4057qib7 6859 16 graft graft NN cord-005453-4057qib7 6859 17 - - HYPH cord-005453-4057qib7 6859 18 versus versus IN cord-005453-4057qib7 6859 19 - - HYPH cord-005453-4057qib7 6859 20 host host NN cord-005453-4057qib7 6859 21 disease disease NN cord-005453-4057qib7 6859 22 ( ( -LRB- cord-005453-4057qib7 6859 23 aGVHD aGVHD NNP cord-005453-4057qib7 6859 24 ) ) -RRB- cord-005453-4057qib7 6859 25 were be VBD cord-005453-4057qib7 6859 26 12.50 12.50 CD cord-005453-4057qib7 6859 27 % % NN cord-005453-4057qib7 6859 28 and and CC cord-005453-4057qib7 6859 29 33.30 33.30 CD cord-005453-4057qib7 6859 30 % % NN cord-005453-4057qib7 6859 31 ( ( -LRB- cord-005453-4057qib7 6859 32 P p NN cord-005453-4057qib7 6859 33 = = SYM cord-005453-4057qib7 6859 34 0.121 0.121 CD cord-005453-4057qib7 6859 35 ) ) -RRB- cord-005453-4057qib7 6859 36 , , , cord-005453-4057qib7 6859 37 grade grade NN cord-005453-4057qib7 6859 38 II II NNP cord-005453-4057qib7 6859 39 - - HYPH cord-005453-4057qib7 6859 40 IV IV NNP cord-005453-4057qib7 6859 41 aGVHD aGVHD NNP cord-005453-4057qib7 6859 42 were be VBD cord-005453-4057qib7 6859 43 6.25 6.25 CD cord-005453-4057qib7 6859 44 % % NN cord-005453-4057qib7 6859 45 and and CC cord-005453-4057qib7 6859 46 20.00 20.00 CD cord-005453-4057qib7 6859 47 % % NN cord-005453-4057qib7 6859 48 ( ( -LRB- cord-005453-4057qib7 6859 49 P p NN cord-005453-4057qib7 6859 50 = = SYM cord-005453-4057qib7 6859 51 0.209 0.209 CD cord-005453-4057qib7 6859 52 ) ) -RRB- cord-005453-4057qib7 6859 53 ; ; , cord-005453-4057qib7 6859 54 chronic chronic JJ cord-005453-4057qib7 6859 55 GVHD GVHD NNP cord-005453-4057qib7 6859 56 were be VBD cord-005453-4057qib7 6859 57 12.50 12.50 CD cord-005453-4057qib7 6859 58 % % NN cord-005453-4057qib7 6859 59 and and CC cord-005453-4057qib7 6859 60 35.67 35.67 CD cord-005453-4057qib7 6859 61 % % NN cord-005453-4057qib7 6859 62 ( ( -LRB- cord-005453-4057qib7 6859 63 P p NN cord-005453-4057qib7 6859 64 = = SYM cord-005453-4057qib7 6859 65 0.274 0.274 CD cord-005453-4057qib7 6859 66 ) ) -RRB- cord-005453-4057qib7 6859 67 , , , cord-005453-4057qib7 6859 68 moderatesevere moderatesevere NN cord-005453-4057qib7 6859 69 chronic chronic JJ cord-005453-4057qib7 6859 70 GVHD GVHD NNP cord-005453-4057qib7 6859 71 were be VBD cord-005453-4057qib7 6859 72 0.00 0.00 CD cord-005453-4057qib7 6859 73 % % NN cord-005453-4057qib7 6859 74 and and CC cord-005453-4057qib7 6859 75 14.39 14.39 CD cord-005453-4057qib7 6859 76 % % NN cord-005453-4057qib7 6859 77 ( ( -LRB- cord-005453-4057qib7 6859 78 P p NN cord-005453-4057qib7 6859 79 = = SYM cord-005453-4057qib7 6859 80 0.146 0.146 CD cord-005453-4057qib7 6859 81 ) ) -RRB- cord-005453-4057qib7 6859 82 . . . cord-005453-4057qib7 6860 1 In in IN cord-005453-4057qib7 6860 2 haplo haplo NNP cord-005453-4057qib7 6860 3 - - HYPH cord-005453-4057qib7 6860 4 HSCT HSCT NNP cord-005453-4057qib7 6860 5 and and CC cord-005453-4057qib7 6860 6 MSD MSD NNP cord-005453-4057qib7 6860 7 groups group NNS cord-005453-4057qib7 6860 8 the the DT cord-005453-4057qib7 6860 9 incidences incidence NNS cord-005453-4057qib7 6860 10 of of IN cord-005453-4057qib7 6860 11 infection infection NN cord-005453-4057qib7 6860 12 were be VBD cord-005453-4057qib7 6860 13 37.50 37.50 CD cord-005453-4057qib7 6860 14 % % NN cord-005453-4057qib7 6860 15 ( ( -LRB- cord-005453-4057qib7 6860 16 6/16 6/16 CD cord-005453-4057qib7 6860 17 ) ) -RRB- cord-005453-4057qib7 6860 18 and and CC cord-005453-4057qib7 6860 19 33.33 33.33 CD cord-005453-4057qib7 6860 20 % % NN cord-005453-4057qib7 6860 21 ( ( -LRB- cord-005453-4057qib7 6860 22 10/30 10/30 CD cord-005453-4057qib7 6860 23 ) ) -RRB- cord-005453-4057qib7 6861 1 ( ( -LRB- cord-005453-4057qib7 6861 2 P p NN cord-005453-4057qib7 6861 3 = = SYM cord-005453-4057qib7 6861 4 0.777 0.777 CD cord-005453-4057qib7 6861 5 ) ) -RRB- cord-005453-4057qib7 6861 6 . . . cord-005453-4057qib7 6862 1 No no DT cord-005453-4057qib7 6862 2 patient patient NN cord-005453-4057qib7 6862 3 occurred occur VBD cord-005453-4057qib7 6862 4 early early JJ cord-005453-4057qib7 6862 5 death death NN cord-005453-4057qib7 6862 6 and and CC cord-005453-4057qib7 6862 7 relapse relapse NN cord-005453-4057qib7 6862 8 . . . cord-005453-4057qib7 6863 1 3-year 3-year CD cord-005453-4057qib7 6863 2 estimated estimate VBN cord-005453-4057qib7 6863 3 overall overall JJ cord-005453-4057qib7 6863 4 survival survival NN cord-005453-4057qib7 6863 5 ( ( -LRB- cord-005453-4057qib7 6863 6 OS OS NNP cord-005453-4057qib7 6863 7 ) ) -RRB- cord-005453-4057qib7 6863 8 of of IN cord-005453-4057qib7 6863 9 PNH PNH NNP cord-005453-4057qib7 6863 10 and and CC cord-005453-4057qib7 6863 11 PNH PNH NNP cord-005453-4057qib7 6863 12 - - HYPH cord-005453-4057qib7 6863 13 AA AA NNP cord-005453-4057qib7 6863 14 groups group NNS cord-005453-4057qib7 6863 15 were be VBD cord-005453-4057qib7 6863 16 100.0 100.0 CD cord-005453-4057qib7 6863 17 % % NN cord-005453-4057qib7 6863 18 ± ± NNP cord-005453-4057qib7 6863 19 0.0 0.0 CD cord-005453-4057qib7 6863 20 % % NN cord-005453-4057qib7 6863 21 and and CC cord-005453-4057qib7 6863 22 85.7 85.7 CD cord-005453-4057qib7 6863 23 % % NN cord-005453-4057qib7 6863 24 ± ± NNP cord-005453-4057qib7 6863 25 6.6 6.6 CD cord-005453-4057qib7 6863 26 % % NN cord-005453-4057qib7 6863 27 ( ( -LRB- cord-005453-4057qib7 6863 28 P p NN cord-005453-4057qib7 6863 29 = = SYM cord-005453-4057qib7 6863 30 0.141 0.141 CD cord-005453-4057qib7 6863 31 ) ) -RRB- cord-005453-4057qib7 6863 32 , , , cord-005453-4057qib7 6863 33 GVHD GVHD NNP cord-005453-4057qib7 6863 34 - - HYPH cord-005453-4057qib7 6863 35 free free JJ cord-005453-4057qib7 6863 36 and and CC cord-005453-4057qib7 6863 37 failure failure NN cord-005453-4057qib7 6863 38 - - HYPH cord-005453-4057qib7 6863 39 free free JJ cord-005453-4057qib7 6863 40 survival survival NN cord-005453-4057qib7 6863 41 ( ( -LRB- cord-005453-4057qib7 6863 42 GFFS GFFS NNP cord-005453-4057qib7 6863 43 ) ) -RRB- cord-005453-4057qib7 6863 44 were be VBD cord-005453-4057qib7 6863 45 100.0 100.0 CD cord-005453-4057qib7 6863 46 % % NN cord-005453-4057qib7 6863 47 ± ± NNP cord-005453-4057qib7 6863 48 0.0%、78.7 0.0%、78.7 CD cord-005453-4057qib7 6863 49 % % NN cord-005453-4057qib7 6863 50 ± ± CD cord-005453-4057qib7 6863 51 7.7 7.7 CD cord-005453-4057qib7 6863 52 % % NN cord-005453-4057qib7 6863 53 ( ( -LRB- cord-005453-4057qib7 6863 54 P p NN cord-005453-4057qib7 6863 55 = = SYM cord-005453-4057qib7 6863 56 0.067 0.067 CD cord-005453-4057qib7 6863 57 ) ) -RRB- cord-005453-4057qib7 6863 58 . . . cord-005453-4057qib7 6864 1 Conclusions conclusion NNS cord-005453-4057qib7 6864 2 : : : cord-005453-4057qib7 6865 1 The the DT cord-005453-4057qib7 6865 2 preliminary preliminary JJ cord-005453-4057qib7 6865 3 results result NNS cord-005453-4057qib7 6865 4 indicated indicate VBD cord-005453-4057qib7 6865 5 that that IN cord-005453-4057qib7 6865 6 allo allo NN cord-005453-4057qib7 6865 7 - - HYPH cord-005453-4057qib7 6865 8 HSCT HSCT NNP cord-005453-4057qib7 6865 9 is be VBZ cord-005453-4057qib7 6865 10 a a DT cord-005453-4057qib7 6865 11 feasible feasible JJ cord-005453-4057qib7 6865 12 choice choice NN cord-005453-4057qib7 6865 13 for for IN cord-005453-4057qib7 6865 14 PNH PNH NNP cord-005453-4057qib7 6865 15 with with IN cord-005453-4057qib7 6865 16 favorable favorable JJ cord-005453-4057qib7 6865 17 outcomes outcome NNS cord-005453-4057qib7 6865 18 , , , cord-005453-4057qib7 6865 19 time time NN cord-005453-4057qib7 6865 20 for for IN cord-005453-4057qib7 6865 21 myeloid myeloid NN cord-005453-4057qib7 6865 22 and and CC cord-005453-4057qib7 6865 23 platelet platelet NN cord-005453-4057qib7 6865 24 engraftment engraftment NN cord-005453-4057qib7 6865 25 in in IN cord-005453-4057qib7 6865 26 PNH PNH NNP cord-005453-4057qib7 6865 27 group group NN cord-005453-4057qib7 6865 28 were be VBD cord-005453-4057qib7 6865 29 faster fast JJR cord-005453-4057qib7 6865 30 than than IN cord-005453-4057qib7 6865 31 PNH PNH NNP cord-005453-4057qib7 6865 32 - - HYPH cord-005453-4057qib7 6865 33 AA AA NNP cord-005453-4057qib7 6865 34 group group NN cord-005453-4057qib7 6865 35 . . . cord-005453-4057qib7 6866 1 There there EX cord-005453-4057qib7 6866 2 were be VBD cord-005453-4057qib7 6866 3 no no DT cord-005453-4057qib7 6866 4 differences difference NNS cord-005453-4057qib7 6866 5 in in IN cord-005453-4057qib7 6866 6 OS OS NNP cord-005453-4057qib7 6866 7 and and CC cord-005453-4057qib7 6866 8 GFFS GFFS NNP cord-005453-4057qib7 6866 9 between between IN cord-005453-4057qib7 6866 10 PNH PNH NNP cord-005453-4057qib7 6866 11 group group NN cord-005453-4057qib7 6866 12 and and CC cord-005453-4057qib7 6866 13 PNH PNH NNP cord-005453-4057qib7 6866 14 - - HYPH cord-005453-4057qib7 6866 15 AA AA NNP cord-005453-4057qib7 6866 16 group group NN cord-005453-4057qib7 6866 17 . . . cord-005453-4057qib7 6867 1 Disclosure disclosure NN cord-005453-4057qib7 6867 2 : : : cord-005453-4057qib7 6867 3 no no DT cord-005453-4057qib7 6867 4 disclosure disclosure NN cord-005453-4057qib7 6867 5 Pattern pattern NN cord-005453-4057qib7 6867 6 of of IN cord-005453-4057qib7 6867 7 calcineurin calcineurin JJ cord-005453-4057qib7 6867 8 inhibitor inhibitor NN cord-005453-4057qib7 6867 9 - - HYPH cord-005453-4057qib7 6867 10 associated associate VBN cord-005453-4057qib7 6867 11 neurotoxicity neurotoxicity NN cord-005453-4057qib7 6867 12 in in IN cord-005453-4057qib7 6867 13 sickle sickle NN cord-005453-4057qib7 6867 14 cell cell NN cord-005453-4057qib7 6867 15 disease disease NN cord-005453-4057qib7 6867 16 patients patient NNS cord-005453-4057qib7 6867 17 receiving receive VBG cord-005453-4057qib7 6867 18 a a DT cord-005453-4057qib7 6867 19 stem stem NN cord-005453-4057qib7 6867 20 cell cell NN cord-005453-4057qib7 6867 21 transplantation transplantation NN cord-005453-4057qib7 6867 22 Background background NN cord-005453-4057qib7 6867 23 : : : cord-005453-4057qib7 6868 1 Allogeneic allogeneic IN cord-005453-4057qib7 6868 2 HSCT HSCT NNP cord-005453-4057qib7 6868 3 with with IN cord-005453-4057qib7 6868 4 a a DT cord-005453-4057qib7 6868 5 MSD MSD NNP cord-005453-4057qib7 6868 6 represents represent VBZ cord-005453-4057qib7 6868 7 currently currently RB cord-005453-4057qib7 6868 8 the the DT cord-005453-4057qib7 6868 9 only only JJ cord-005453-4057qib7 6868 10 curative curative JJ cord-005453-4057qib7 6868 11 option option NN cord-005453-4057qib7 6868 12 for for IN cord-005453-4057qib7 6868 13 sickle sickle NN cord-005453-4057qib7 6868 14 cell cell NN cord-005453-4057qib7 6868 15 disease disease NN cord-005453-4057qib7 6868 16 ( ( -LRB- cord-005453-4057qib7 6868 17 SCD SCD NNP cord-005453-4057qib7 6868 18 ) ) -RRB- cord-005453-4057qib7 6868 19 , , , cord-005453-4057qib7 6868 20 limited limit VBN cord-005453-4057qib7 6868 21 by by IN cord-005453-4057qib7 6868 22 a a DT cord-005453-4057qib7 6868 23 donor donor NN cord-005453-4057qib7 6868 24 availability availability NN cord-005453-4057qib7 6868 25 < < XX cord-005453-4057qib7 6868 26 20 20 CD cord-005453-4057qib7 6868 27 % % NN cord-005453-4057qib7 6868 28 . . . cord-005453-4057qib7 6869 1 Neurotoxicity neurotoxicity NN cord-005453-4057qib7 6869 2 ( ( -LRB- cord-005453-4057qib7 6869 3 NT NT NNP cord-005453-4057qib7 6869 4 ) ) -RRB- cord-005453-4057qib7 6869 5 contributes contribute VBZ cord-005453-4057qib7 6869 6 significantly significantly RB cord-005453-4057qib7 6869 7 to to IN cord-005453-4057qib7 6869 8 HSCT HSCT NNP cord-005453-4057qib7 6869 9 - - HYPH cord-005453-4057qib7 6869 10 associated associate VBN cord-005453-4057qib7 6869 11 morbidity morbidity NN cord-005453-4057qib7 6869 12 and and CC cord-005453-4057qib7 6869 13 mortality mortality NN cord-005453-4057qib7 6869 14 . . . cord-005453-4057qib7 6870 1 Calcineurin Calcineurin NNP cord-005453-4057qib7 6870 2 - - HYPH cord-005453-4057qib7 6870 3 inhibitor inhibitor NN cord-005453-4057qib7 6870 4 ( ( -LRB- cord-005453-4057qib7 6870 5 CNI CNI NNP cord-005453-4057qib7 6870 6 ) ) -RRB- cord-005453-4057qib7 6870 7 associated associate VBD cord-005453-4057qib7 6870 8 NT NT NNP cord-005453-4057qib7 6870 9 ranges range VBZ cord-005453-4057qib7 6870 10 from from IN cord-005453-4057qib7 6870 11 4.2%-28.8 4.2%-28.8 CD cord-005453-4057qib7 6870 12 % % NN cord-005453-4057qib7 6870 13 ( ( -LRB- cord-005453-4057qib7 6870 14 severe severe JJ cord-005453-4057qib7 6870 15 NT NT NNP cord-005453-4057qib7 6870 16 4%-11 4%-11 CD cord-005453-4057qib7 6870 17 % % NN cord-005453-4057qib7 6870 18 ) ) -RRB- cord-005453-4057qib7 6870 19 . . . cord-005453-4057qib7 6871 1 The the DT cord-005453-4057qib7 6871 2 elevated elevated JJ cord-005453-4057qib7 6871 3 incidence incidence NN cord-005453-4057qib7 6871 4 of of IN cord-005453-4057qib7 6871 5 NT NT NNP cord-005453-4057qib7 6871 6 in in IN cord-005453-4057qib7 6871 7 SCD SCD NNP cord-005453-4057qib7 6871 8 ( ( -LRB- cord-005453-4057qib7 6871 9 around around IN cord-005453-4057qib7 6871 10 30 30 CD cord-005453-4057qib7 6871 11 % % NN cord-005453-4057qib7 6871 12 ) ) -RRB- cord-005453-4057qib7 6871 13 might may MD cord-005453-4057qib7 6871 14 be be VB cord-005453-4057qib7 6871 15 triggered trigger VBN cord-005453-4057qib7 6871 16 by by IN cord-005453-4057qib7 6871 17 the the DT cord-005453-4057qib7 6871 18 systemic systemic JJ cord-005453-4057qib7 6871 19 vasculopathy vasculopathy NN cord-005453-4057qib7 6871 20 of of IN cord-005453-4057qib7 6871 21 SCD SCD NNP cord-005453-4057qib7 6871 22 , , , cord-005453-4057qib7 6871 23 with with IN cord-005453-4057qib7 6871 24 the the DT cord-005453-4057qib7 6871 25 brain brain NN cord-005453-4057qib7 6871 26 being be VBG cord-005453-4057qib7 6871 27 the the DT cord-005453-4057qib7 6871 28 primary primary JJ cord-005453-4057qib7 6871 29 target target NN cord-005453-4057qib7 6871 30 . . . cord-005453-4057qib7 6872 1 Although although IN cord-005453-4057qib7 6872 2 both both DT cord-005453-4057qib7 6872 3 cyclosporine cyclosporine NN cord-005453-4057qib7 6872 4 A a NN cord-005453-4057qib7 6872 5 ( ( -LRB- cord-005453-4057qib7 6872 6 CsA csa NN cord-005453-4057qib7 6872 7 ) ) -RRB- cord-005453-4057qib7 6872 8 and and CC cord-005453-4057qib7 6872 9 tacrolimus tacrolimus NNP cord-005453-4057qib7 6872 10 ( ( -LRB- cord-005453-4057qib7 6872 11 FK506 FK506 NNP cord-005453-4057qib7 6872 12 ) ) -RRB- cord-005453-4057qib7 6872 13 have have VB cord-005453-4057qib7 6872 14 a a DT cord-005453-4057qib7 6872 15 proinflammatory proinflammatory JJ cord-005453-4057qib7 6872 16 effect effect NN cord-005453-4057qib7 6872 17 , , , cord-005453-4057qib7 6872 18 it -PRON- PRP cord-005453-4057qib7 6872 19 is be VBZ cord-005453-4057qib7 6872 20 more more RBR cord-005453-4057qib7 6872 21 pronounced pronounced JJ cord-005453-4057qib7 6872 22 in in IN cord-005453-4057qib7 6872 23 CsA. CsA. NNP cord-005453-4057qib7 6873 1 Infusion infusion NN cord-005453-4057qib7 6873 2 modalities modality NNS cord-005453-4057qib7 6873 3 also also RB cord-005453-4057qib7 6873 4 might may MD cord-005453-4057qib7 6873 5 impact impact VB cord-005453-4057qib7 6873 6 ( ( -LRB- cord-005453-4057qib7 6873 7 10.3 10.3 CD cord-005453-4057qib7 6873 8 % % NN cord-005453-4057qib7 6873 9 after after IN cord-005453-4057qib7 6873 10 bolus bolus NN cord-005453-4057qib7 6873 11 injections injection NNS cord-005453-4057qib7 6873 12 versus versus IN cord-005453-4057qib7 6873 13 3.3 3.3 CD cord-005453-4057qib7 6873 14 % % NN cord-005453-4057qib7 6873 15 after after IN cord-005453-4057qib7 6873 16 continuous continuous JJ cord-005453-4057qib7 6873 17 infusion infusion NN cord-005453-4057qib7 6873 18 ) ) -RRB- cord-005453-4057qib7 6873 19 . . . cord-005453-4057qib7 6874 1 Methods method NNS cord-005453-4057qib7 6874 2 : : : cord-005453-4057qib7 6874 3 In in IN cord-005453-4057qib7 6874 4 a a DT cord-005453-4057qib7 6874 5 pilot pilot NN cord-005453-4057qib7 6874 6 study study NN cord-005453-4057qib7 6874 7 , , , cord-005453-4057qib7 6874 8 we -PRON- PRP cord-005453-4057qib7 6874 9 compared compare VBD cord-005453-4057qib7 6874 10 T t NN cord-005453-4057qib7 6874 11 - - HYPH cord-005453-4057qib7 6874 12 cell cell NN cord-005453-4057qib7 6874 13 depleted deplete VBN cord-005453-4057qib7 6874 14 haploidentical haploidentical JJ cord-005453-4057qib7 6874 15 HSCT HSCT NNP cord-005453-4057qib7 6874 16 ( ( -LRB- cord-005453-4057qib7 6874 17 T T NNP cord-005453-4057qib7 6874 18 - - HYPH cord-005453-4057qib7 6874 19 haplo haplo NNP cord-005453-4057qib7 6874 20 HSCT HSCT NNP cord-005453-4057qib7 6874 21 ) ) -RRB- cord-005453-4057qib7 6874 22 with with IN cord-005453-4057qib7 6874 23 MSD MSD NNP cord-005453-4057qib7 6874 24 HSCT HSCT NNP cord-005453-4057qib7 6874 25 in in IN cord-005453-4057qib7 6874 26 patients patient NNS cord-005453-4057qib7 6874 27 ( ( -LRB- cord-005453-4057qib7 6874 28 pts pt NNS cord-005453-4057qib7 6874 29 ) ) -RRB- cord-005453-4057qib7 6874 30 with with IN cord-005453-4057qib7 6874 31 advanced advanced JJ cord-005453-4057qib7 6874 32 stage stage NN cord-005453-4057qib7 6874 33 SCD SCD NNP cord-005453-4057qib7 6874 34 , , , cord-005453-4057qib7 6874 35 using use VBG cord-005453-4057qib7 6874 36 almost almost RB cord-005453-4057qib7 6874 37 identical identical JJ cord-005453-4057qib7 6874 38 conditioning conditioning NN cord-005453-4057qib7 6874 39 regimens regimen NNS cord-005453-4057qib7 6874 40 . . . cord-005453-4057qib7 6875 1 32 32 CD cord-005453-4057qib7 6875 2 pts pts NN cord-005453-4057qib7 6875 3 ( ( -LRB- cord-005453-4057qib7 6875 4 3 3 CD cord-005453-4057qib7 6875 5 - - SYM cord-005453-4057qib7 6875 6 31 31 CD cord-005453-4057qib7 6875 7 years year NNS cord-005453-4057qib7 6875 8 ; ; : cord-005453-4057qib7 6875 9 yrs yr NNS cord-005453-4057qib7 6875 10 ) ) -RRB- cord-005453-4057qib7 6875 11 with with IN cord-005453-4057qib7 6875 12 homozygous homozygous JJ cord-005453-4057qib7 6875 13 SCD SCD NNP cord-005453-4057qib7 6875 14 or or CC cord-005453-4057qib7 6875 15 HbS hbs NN cord-005453-4057qib7 6875 16 0/+ 0/+ . cord-005453-4057qib7 6876 1 ß ß LS cord-005453-4057qib7 6876 2 - - : cord-005453-4057qib7 6876 3 Thal Thal NNP cord-005453-4057qib7 6876 4 were be VBD cord-005453-4057qib7 6876 5 treated treat VBN cord-005453-4057qib7 6876 6 between between IN cord-005453-4057qib7 6876 7 2012 2012 CD cord-005453-4057qib7 6876 8 and and CC cord-005453-4057qib7 6876 9 2018 2018 CD cord-005453-4057qib7 6876 10 . . . cord-005453-4057qib7 6877 1 Nine nine CD cord-005453-4057qib7 6877 2 pts pt NNS cord-005453-4057qib7 6877 3 received receive VBD cord-005453-4057qib7 6877 4 a a DT cord-005453-4057qib7 6877 5 MSD MSD NNP cord-005453-4057qib7 6877 6 bone bone NN cord-005453-4057qib7 6877 7 marrow marrow NN cord-005453-4057qib7 6877 8 graft graft NN cord-005453-4057qib7 6877 9 , , , cord-005453-4057qib7 6877 10 23 23 CD cord-005453-4057qib7 6877 11 pts pt NNS cord-005453-4057qib7 6877 12 received receive VBD cord-005453-4057qib7 6877 13 24 24 CD cord-005453-4057qib7 6877 14 T T NNP cord-005453-4057qib7 6877 15 - - HYPH cord-005453-4057qib7 6877 16 haplo haplo NNP cord-005453-4057qib7 6877 17 - - HYPH cord-005453-4057qib7 6877 18 HSCT HSCT NNP cord-005453-4057qib7 6877 19 ( ( -LRB- cord-005453-4057qib7 6877 20 1 1 CD cord-005453-4057qib7 6877 21 second second JJ cord-005453-4057qib7 6877 22 T T NNP cord-005453-4057qib7 6877 23 - - HYPH cord-005453-4057qib7 6877 24 haplo haplo NNP cord-005453-4057qib7 6877 25 due due IN cord-005453-4057qib7 6877 26 to to IN cord-005453-4057qib7 6877 27 graft graft NN cord-005453-4057qib7 6877 28 rejection rejection NN cord-005453-4057qib7 6877 29 ) ) -RRB- cord-005453-4057qib7 6877 30 . . . cord-005453-4057qib7 6878 1 Immunosuppression Immunosuppression NNP cord-005453-4057qib7 6878 2 consisted consist VBD cord-005453-4057qib7 6878 3 of of IN cord-005453-4057qib7 6878 4 either either DT cord-005453-4057qib7 6878 5 CsA CsA NNP cord-005453-4057qib7 6878 6 ( ( -LRB- cord-005453-4057qib7 6878 7 6 6 CD cord-005453-4057qib7 6878 8 MSD MSD NNP cord-005453-4057qib7 6878 9 , , , cord-005453-4057qib7 6878 10 16 16 CD cord-005453-4057qib7 6878 11 T t NN cord-005453-4057qib7 6878 12 - - HYPH cord-005453-4057qib7 6878 13 haplo haplo NNP cord-005453-4057qib7 6878 14 ) ) -RRB- cord-005453-4057qib7 6878 15 or or CC cord-005453-4057qib7 6879 1 FK506 FK506 NNP cord-005453-4057qib7 6879 2 ( ( -LRB- cord-005453-4057qib7 6879 3 3 3 CD cord-005453-4057qib7 6879 4 MSD MSD NNP cord-005453-4057qib7 6879 5 , , , cord-005453-4057qib7 6879 6 , , , cord-005453-4057qib7 6879 7 in in IN cord-005453-4057qib7 6879 8 combination combination NN cord-005453-4057qib7 6879 9 with with IN cord-005453-4057qib7 6879 10 mycophenolate mycophenolate NNP cord-005453-4057qib7 6879 11 mofetil mofetil NNP cord-005453-4057qib7 6879 12 ( ( -LRB- cord-005453-4057qib7 6879 13 MMF MMF NNP cord-005453-4057qib7 6879 14 ) ) -RRB- cord-005453-4057qib7 6879 15 . . . cord-005453-4057qib7 6880 1 FK506 FK506 NNP cord-005453-4057qib7 6880 2 was be VBD cord-005453-4057qib7 6880 3 administered administer VBN cord-005453-4057qib7 6880 4 as as IN cord-005453-4057qib7 6880 5 a a DT cord-005453-4057qib7 6880 6 20-hours 20-hours CD cord-005453-4057qib7 6880 7 continuous continuous JJ cord-005453-4057qib7 6880 8 infusion infusion NN cord-005453-4057qib7 6880 9 , , , cord-005453-4057qib7 6880 10 CsA csa NN cord-005453-4057qib7 6880 11 as as IN cord-005453-4057qib7 6880 12 4-hours 4-hours CD cord-005453-4057qib7 6880 13 bolus bolus NN cord-005453-4057qib7 6880 14 injections injection NNS cord-005453-4057qib7 6880 15 ; ; . cord-005453-4057qib7 6881 1 both both DT cord-005453-4057qib7 6881 2 target target NN cord-005453-4057qib7 6881 3 level level NN cord-005453-4057qib7 6881 4 adjusted adjust VBN cord-005453-4057qib7 6881 5 ( ( -LRB- cord-005453-4057qib7 6881 6 CsA CsA NNP cord-005453-4057qib7 6881 7 : : : cord-005453-4057qib7 6881 8 100 100 CD cord-005453-4057qib7 6881 9 - - SYM cord-005453-4057qib7 6881 10 120 120 CD cord-005453-4057qib7 6881 11 ng ng NN cord-005453-4057qib7 6881 12 / / SYM cord-005453-4057qib7 6881 13 ml ml XX cord-005453-4057qib7 6881 14 ; ; : cord-005453-4057qib7 6881 15 FK506 fk506 NN cord-005453-4057qib7 6881 16 : : : cord-005453-4057qib7 6881 17 5 5 CD cord-005453-4057qib7 6881 18 - - SYM cord-005453-4057qib7 6881 19 8 8 CD cord-005453-4057qib7 6881 20 ng/ ng/ NN cord-005453-4057qib7 6881 21 ml ml NNP cord-005453-4057qib7 6881 22 ) ) -RRB- cord-005453-4057qib7 6881 23 . . . cord-005453-4057qib7 6882 1 Duration duration NN cord-005453-4057qib7 6882 2 of of IN cord-005453-4057qib7 6882 3 immunosuppression immunosuppression NN cord-005453-4057qib7 6882 4 was be VBD cord-005453-4057qib7 6882 5 > > NFP cord-005453-4057qib7 6882 6 6 6 CD cord-005453-4057qib7 6882 7 months month NNS cord-005453-4057qib7 6882 8 in in IN cord-005453-4057qib7 6882 9 Thaplo Thaplo NNP cord-005453-4057qib7 6882 10 - - HYPH cord-005453-4057qib7 6882 11 SCT SCT NNP cord-005453-4057qib7 6882 12 and and CC cord-005453-4057qib7 6882 13 < < NNP cord-005453-4057qib7 6882 14 6 6 CD cord-005453-4057qib7 6882 15 months month NNS cord-005453-4057qib7 6882 16 in in IN cord-005453-4057qib7 6882 17 MSD MSD NNP cord-005453-4057qib7 6882 18 , , , cord-005453-4057qib7 6882 19 depending depend VBG cord-005453-4057qib7 6882 20 on on IN cord-005453-4057qib7 6882 21 chimerism chimerism NN cord-005453-4057qib7 6882 22 . . . cord-005453-4057qib7 6883 1 Results result NNS cord-005453-4057qib7 6883 2 : : : cord-005453-4057qib7 6884 1 CNI CNI NNP cord-005453-4057qib7 6884 2 - - HYPH cord-005453-4057qib7 6884 3 related relate VBN cord-005453-4057qib7 6884 4 NT NT NNP cord-005453-4057qib7 6884 5 was be VBD cord-005453-4057qib7 6884 6 observed observe VBN cord-005453-4057qib7 6884 7 in in IN cord-005453-4057qib7 6884 8 36.4 36.4 CD cord-005453-4057qib7 6884 9 % % NN cord-005453-4057qib7 6884 10 , , , cord-005453-4057qib7 6884 11 severe severe JJ cord-005453-4057qib7 6884 12 NT NT NNP cord-005453-4057qib7 6884 13 ( ( -LRB- cord-005453-4057qib7 6884 14 PRES PRES NNP cord-005453-4057qib7 6884 15 , , , cord-005453-4057qib7 6884 16 visual visual JJ cord-005453-4057qib7 6884 17 disturbance disturbance NN cord-005453-4057qib7 6884 18 , , , cord-005453-4057qib7 6884 19 aphasia aphasia NN cord-005453-4057qib7 6884 20 ) ) -RRB- cord-005453-4057qib7 6884 21 in in IN cord-005453-4057qib7 6884 22 21.2 21.2 CD cord-005453-4057qib7 6884 23 % % NN cord-005453-4057qib7 6884 24 . . . cord-005453-4057qib7 6885 1 NT NT NNP cord-005453-4057qib7 6885 2 was be VBD cord-005453-4057qib7 6885 3 more more RBR cord-005453-4057qib7 6885 4 prevalent prevalent JJ cord-005453-4057qib7 6885 5 in in IN cord-005453-4057qib7 6885 6 MSD MSD NNP cord-005453-4057qib7 6885 7 ( ( -LRB- cord-005453-4057qib7 6885 8 n=5 n=5 JJ cord-005453-4057qib7 6885 9 , , , cord-005453-4057qib7 6885 10 55.5 55.5 CD cord-005453-4057qib7 6885 11 % % NN cord-005453-4057qib7 6885 12 ) ) -RRB- cord-005453-4057qib7 6885 13 than than IN cord-005453-4057qib7 6885 14 in in IN cord-005453-4057qib7 6885 15 T T NNP cord-005453-4057qib7 6885 16 - - HYPH cord-005453-4057qib7 6885 17 haplo haplo NNP cord-005453-4057qib7 6885 18 ( ( -LRB- cord-005453-4057qib7 6885 19 n=7 n=7 NNS cord-005453-4057qib7 6885 20 , , , cord-005453-4057qib7 6885 21 29.2 29.2 CD cord-005453-4057qib7 6885 22 % % NN cord-005453-4057qib7 6885 23 ) ) -RRB- cord-005453-4057qib7 6885 24 . . . cord-005453-4057qib7 6886 1 The the DT cord-005453-4057qib7 6886 2 incidence incidence NN cord-005453-4057qib7 6886 3 of of IN cord-005453-4057qib7 6886 4 NT NT NNP cord-005453-4057qib7 6886 5 was be VBD cord-005453-4057qib7 6886 6 identical identical JJ cord-005453-4057qib7 6886 7 under under IN cord-005453-4057qib7 6886 8 CsA csa NN cord-005453-4057qib7 6886 9 ( ( -LRB- cord-005453-4057qib7 6886 10 8/22 8/22 CD cord-005453-4057qib7 6886 11 ; ; : cord-005453-4057qib7 6886 12 36.4 36.4 CD cord-005453-4057qib7 6886 13 % % NN cord-005453-4057qib7 6886 14 ) ) -RRB- cord-005453-4057qib7 6886 15 and and CC cord-005453-4057qib7 6886 16 FK506 fk506 JJ cord-005453-4057qib7 6886 17 ( ( -LRB- cord-005453-4057qib7 6886 18 4/11 4/11 CD cord-005453-4057qib7 6886 19 ; ; : cord-005453-4057qib7 6886 20 36.4 36.4 CD cord-005453-4057qib7 6886 21 % % NN cord-005453-4057qib7 6886 22 ) ) -RRB- cord-005453-4057qib7 6886 23 , , , cord-005453-4057qib7 6886 24 however however RB cord-005453-4057qib7 6886 25 the the DT cord-005453-4057qib7 6886 26 majority majority NN cord-005453-4057qib7 6886 27 of of IN cord-005453-4057qib7 6886 28 severe severe JJ cord-005453-4057qib7 6886 29 NT NT NNP cord-005453-4057qib7 6886 30 ( ( -LRB- cord-005453-4057qib7 6886 31 all all DT cord-005453-4057qib7 6886 32 PRES PRES NNP cord-005453-4057qib7 6886 33 ) ) -RRB- cord-005453-4057qib7 6886 34 occurred occur VBD cord-005453-4057qib7 6886 35 with with IN cord-005453-4057qib7 6886 36 CsA. CsA. NNP cord-005453-4057qib7 6887 1 Complete complete JJ cord-005453-4057qib7 6887 2 recovery recovery NN cord-005453-4057qib7 6887 3 of of IN cord-005453-4057qib7 6887 4 NT NT NNP cord-005453-4057qib7 6887 5 was be VBD cord-005453-4057qib7 6887 6 achieved achieve VBN cord-005453-4057qib7 6887 7 in in IN cord-005453-4057qib7 6887 8 all all DT cord-005453-4057qib7 6887 9 pts pt NNS cord-005453-4057qib7 6887 10 either either CC cord-005453-4057qib7 6887 11 spontaneously spontaneously RB cord-005453-4057qib7 6887 12 or or CC cord-005453-4057qib7 6887 13 after after IN cord-005453-4057qib7 6887 14 switching switch VBG cord-005453-4057qib7 6887 15 to to IN cord-005453-4057qib7 6887 16 FK506 FK506 NNP cord-005453-4057qib7 6887 17 / / SYM cord-005453-4057qib7 6887 18 everolimus everolimus NN cord-005453-4057qib7 6887 19 or or CC cord-005453-4057qib7 6887 20 withdrawal withdrawal NN cord-005453-4057qib7 6887 21 of of IN cord-005453-4057qib7 6887 22 FK506 fk506 NN cord-005453-4057qib7 6887 23 . . . cord-005453-4057qib7 6888 1 Moreover moreover RB cord-005453-4057qib7 6888 2 , , , cord-005453-4057qib7 6888 3 66.6 66.6 CD cord-005453-4057qib7 6888 4 % % NN cord-005453-4057qib7 6888 5 of of IN cord-005453-4057qib7 6888 6 pts pt NNS cord-005453-4057qib7 6888 7 with with IN cord-005453-4057qib7 6888 8 NT NT NNP cord-005453-4057qib7 6888 9 were be VBD cord-005453-4057qib7 6888 10 > > NNS cord-005453-4057qib7 6888 11 18 18 CD cord-005453-4057qib7 6888 12 yrs yr NNS cord-005453-4057qib7 6888 13 , , , cord-005453-4057qib7 6888 14 and and CC cord-005453-4057qib7 6888 15 91.6 91.6 CD cord-005453-4057qib7 6888 16 % % NN cord-005453-4057qib7 6888 17 > > SYM cord-005453-4057qib7 6888 18 12 12 CD cord-005453-4057qib7 6888 19 yrs yr NNS cord-005453-4057qib7 6888 20 , , , cord-005453-4057qib7 6888 21 suggesting suggest VBG cord-005453-4057qib7 6888 22 an an DT cord-005453-4057qib7 6888 23 increased increase VBN cord-005453-4057qib7 6888 24 risk risk NN cord-005453-4057qib7 6888 25 with with IN cord-005453-4057qib7 6888 26 age age NN cord-005453-4057qib7 6888 27 . . . cord-005453-4057qib7 6889 1 Only only RB cord-005453-4057qib7 6889 2 37.5 37.5 CD cord-005453-4057qib7 6889 3 % % NN cord-005453-4057qib7 6889 4 of of IN cord-005453-4057qib7 6889 5 pts pt NNS cord-005453-4057qib7 6889 6 with with IN cord-005453-4057qib7 6889 7 pre pre JJ cord-005453-4057qib7 6889 8 - - JJ cord-005453-4057qib7 6889 9 existing existing JJ cord-005453-4057qib7 6889 10 cerebrovascular cerebrovascular JJ cord-005453-4057qib7 6889 11 disease disease NN cord-005453-4057qib7 6889 12 experienced experience VBD cord-005453-4057qib7 6889 13 post post JJ cord-005453-4057qib7 6889 14 - - JJ cord-005453-4057qib7 6889 15 HSCT HSCT NNP cord-005453-4057qib7 6889 16 NT NT NNP cord-005453-4057qib7 6889 17 . . . cord-005453-4057qib7 6890 1 Of of IN cord-005453-4057qib7 6890 2 note note NN cord-005453-4057qib7 6890 3 , , , cord-005453-4057qib7 6890 4 57.1 57.1 CD cord-005453-4057qib7 6890 5 % % NN cord-005453-4057qib7 6890 6 of of IN cord-005453-4057qib7 6890 7 pts pts NN cord-005453-4057qib7 6890 8 with with IN cord-005453-4057qib7 6890 9 severe severe JJ cord-005453-4057qib7 6890 10 NT NT NNP cord-005453-4057qib7 6890 11 also also RB cord-005453-4057qib7 6890 12 developed develop VBD cord-005453-4057qib7 6890 13 mild mild JJ cord-005453-4057qib7 6890 14 acute acute JJ cord-005453-4057qib7 6890 15 GvHD gvhd NN cord-005453-4057qib7 6890 16 . . . cord-005453-4057qib7 6891 1 The the DT cord-005453-4057qib7 6891 2 overall overall JJ cord-005453-4057qib7 6891 3 ( ( -LRB- cord-005453-4057qib7 6891 4 OS OS NNP cord-005453-4057qib7 6891 5 ) ) -RRB- cord-005453-4057qib7 6891 6 and and CC cord-005453-4057qib7 6891 7 disease disease NN cord-005453-4057qib7 6891 8 - - HYPH cord-005453-4057qib7 6891 9 free free JJ cord-005453-4057qib7 6891 10 survival survival NN cord-005453-4057qib7 6891 11 ( ( -LRB- cord-005453-4057qib7 6891 12 DFS DFS NNP cord-005453-4057qib7 6891 13 ) ) -RRB- cord-005453-4057qib7 6891 14 with with IN cord-005453-4057qib7 6891 15 a a DT cord-005453-4057qib7 6891 16 median median JJ cord-005453-4057qib7 6891 17 follow follow NN cord-005453-4057qib7 6891 18 - - HYPH cord-005453-4057qib7 6891 19 up up NN cord-005453-4057qib7 6891 20 of of IN cord-005453-4057qib7 6891 21 17 17 CD cord-005453-4057qib7 6891 22 months month NNS cord-005453-4057qib7 6891 23 in in IN cord-005453-4057qib7 6891 24 T t NN cord-005453-4057qib7 6891 25 - - HYPH cord-005453-4057qib7 6891 26 haplo haplo NNP cord-005453-4057qib7 6891 27 - - HYPH cord-005453-4057qib7 6891 28 HSCT HSCT NNP cord-005453-4057qib7 6891 29 and and CC cord-005453-4057qib7 6891 30 22 22 CD cord-005453-4057qib7 6891 31 months month NNS cord-005453-4057qib7 6891 32 in in IN cord-005453-4057qib7 6891 33 MSD MSD NNP cord-005453-4057qib7 6891 34 HSCT HSCT NNP cord-005453-4057qib7 6891 35 was be VBD cord-005453-4057qib7 6891 36 91 91 CD cord-005453-4057qib7 6891 37 % % NN cord-005453-4057qib7 6891 38 vs. vs. CC cord-005453-4057qib7 6891 39 100 100 CD cord-005453-4057qib7 6891 40 % % NN cord-005453-4057qib7 6891 41 , , , cord-005453-4057qib7 6891 42 respectively respectively RB cord-005453-4057qib7 6891 43 . . . cord-005453-4057qib7 6892 1 Conclusions conclusion NNS cord-005453-4057qib7 6892 2 : : : cord-005453-4057qib7 6893 1 Our -PRON- PRP$ cord-005453-4057qib7 6893 2 data datum NNS cord-005453-4057qib7 6893 3 confirm confirm VBP cord-005453-4057qib7 6893 4 an an DT cord-005453-4057qib7 6893 5 elevated elevated JJ cord-005453-4057qib7 6893 6 NT NT NNP cord-005453-4057qib7 6893 7 risk risk NN cord-005453-4057qib7 6893 8 in in IN cord-005453-4057qib7 6893 9 SCD SCD NNP cord-005453-4057qib7 6893 10 pts pts NN cord-005453-4057qib7 6893 11 following follow VBG cord-005453-4057qib7 6893 12 allo allo NN cord-005453-4057qib7 6893 13 - - HYPH cord-005453-4057qib7 6893 14 HSCT HSCT NNP cord-005453-4057qib7 6893 15 . . . cord-005453-4057qib7 6894 1 Importantly importantly RB cord-005453-4057qib7 6894 2 , , , cord-005453-4057qib7 6894 3 the the DT cord-005453-4057qib7 6894 4 incidence incidence NN cord-005453-4057qib7 6894 5 of of IN cord-005453-4057qib7 6894 6 NT NT NNP cord-005453-4057qib7 6894 7 seems seem VBZ cord-005453-4057qib7 6894 8 to to TO cord-005453-4057qib7 6894 9 be be VB cord-005453-4057qib7 6894 10 related relate VBN cord-005453-4057qib7 6894 11 to to IN cord-005453-4057qib7 6894 12 age age NN cord-005453-4057qib7 6894 13 ( ( -LRB- cord-005453-4057qib7 6894 14 91 91 CD cord-005453-4057qib7 6894 15 % % NN cord-005453-4057qib7 6894 16 of of IN cord-005453-4057qib7 6894 17 pts pt NNS cord-005453-4057qib7 6894 18 with with IN cord-005453-4057qib7 6894 19 NT NT NNP cord-005453-4057qib7 6894 20 were be VBD cord-005453-4057qib7 6894 21 > > NNS cord-005453-4057qib7 6894 22 10 10 CD cord-005453-4057qib7 6894 23 yrs yr NNS cord-005453-4057qib7 6894 24 ) ) -RRB- cord-005453-4057qib7 6894 25 , , , cord-005453-4057qib7 6894 26 donor donor NN cord-005453-4057qib7 6894 27 source source NN cord-005453-4057qib7 6894 28 ( ( -LRB- cord-005453-4057qib7 6894 29 MSD MSD NNP cord-005453-4057qib7 6894 30 55.5 55.5 CD cord-005453-4057qib7 6894 31 % % NN cord-005453-4057qib7 6894 32 vs. vs. FW cord-005453-4057qib7 6894 33 T t NN cord-005453-4057qib7 6894 34 - - HYPH cord-005453-4057qib7 6894 35 haplo haplo NNP cord-005453-4057qib7 6894 36 29.2 29.2 CD cord-005453-4057qib7 6894 37 % % NN cord-005453-4057qib7 6894 38 ) ) -RRB- cord-005453-4057qib7 6894 39 and and CC cord-005453-4057qib7 6894 40 type type NN cord-005453-4057qib7 6894 41 of of IN cord-005453-4057qib7 6894 42 CNI CNI NNP cord-005453-4057qib7 6894 43 inhibitor inhibitor NN cord-005453-4057qib7 6894 44 where where WRB cord-005453-4057qib7 6894 45 almost almost RB cord-005453-4057qib7 6894 46 all all DT cord-005453-4057qib7 6894 47 severe severe JJ cord-005453-4057qib7 6894 48 NT NT NNP cord-005453-4057qib7 6894 49 ( ( -LRB- cord-005453-4057qib7 6894 50 71.4 71.4 CD cord-005453-4057qib7 6894 51 % % NN cord-005453-4057qib7 6894 52 , , , cord-005453-4057qib7 6894 53 particularly particularly RB cord-005453-4057qib7 6894 54 all all DT cord-005453-4057qib7 6894 55 PRES PRES NNP cord-005453-4057qib7 6894 56 ) ) -RRB- cord-005453-4057qib7 6894 57 was be VBD cord-005453-4057qib7 6894 58 observed observe VBN cord-005453-4057qib7 6894 59 under under IN cord-005453-4057qib7 6894 60 CsA. CsA. NNP cord-005453-4057qib7 6894 61 Continuous continuous JJ cord-005453-4057qib7 6894 62 infusion infusion NN cord-005453-4057qib7 6894 63 of of IN cord-005453-4057qib7 6894 64 FK506 fk506 NN cord-005453-4057qib7 6894 65 vs. vs. FW cord-005453-4057qib7 6894 66 bolus bolus NN cord-005453-4057qib7 6894 67 injections injection NNS cord-005453-4057qib7 6894 68 of of IN cord-005453-4057qib7 6894 69 CsA CsA NNP cord-005453-4057qib7 6894 70 might may MD cord-005453-4057qib7 6894 71 have have VB cord-005453-4057qib7 6894 72 levelled level VBN cord-005453-4057qib7 6894 73 concentration concentration NN cord-005453-4057qib7 6894 74 peaks peak NNS cord-005453-4057qib7 6894 75 . . . cord-005453-4057qib7 6895 1 The the DT cord-005453-4057qib7 6895 2 NT NT NNP cord-005453-4057qib7 6895 3 observed observe VBD cord-005453-4057qib7 6895 4 with with IN cord-005453-4057qib7 6895 5 CsA CsA NNP cord-005453-4057qib7 6895 6 could could MD cord-005453-4057qib7 6895 7 be be VB cord-005453-4057qib7 6895 8 the the DT cord-005453-4057qib7 6895 9 consequence consequence NN cord-005453-4057qib7 6895 10 of of IN cord-005453-4057qib7 6895 11 predominantly predominantly RB cord-005453-4057qib7 6895 12 CsArelated csarelated JJ cord-005453-4057qib7 6895 13 vascular vascular JJ cord-005453-4057qib7 6895 14 toxicity toxicity NN cord-005453-4057qib7 6895 15 inflicting inflict VBG cord-005453-4057qib7 6895 16 pre pre JJ cord-005453-4057qib7 6895 17 - - JJ cord-005453-4057qib7 6895 18 damaged damaged JJ cord-005453-4057qib7 6895 19 vessels vessel NNS cord-005453-4057qib7 6895 20 in in IN cord-005453-4057qib7 6895 21 SCD SCD NNP cord-005453-4057qib7 6895 22 . . . cord-005453-4057qib7 6896 1 The the DT cord-005453-4057qib7 6896 2 mechanism mechanism NN cord-005453-4057qib7 6896 3 of of IN cord-005453-4057qib7 6896 4 action action NN cord-005453-4057qib7 6896 5 could could MD cord-005453-4057qib7 6896 6 be be VB cord-005453-4057qib7 6896 7 related relate VBN cord-005453-4057qib7 6896 8 to to IN cord-005453-4057qib7 6896 9 other other JJ cord-005453-4057qib7 6896 10 systemic systemic JJ cord-005453-4057qib7 6896 11 endotheliopathies endotheliopathie NNS cord-005453-4057qib7 6896 12 such such JJ cord-005453-4057qib7 6896 13 as as IN cord-005453-4057qib7 6896 14 VOD VOD NNP cord-005453-4057qib7 6896 15 , , , cord-005453-4057qib7 6896 16 TAM TAM NNP cord-005453-4057qib7 6896 17 and and CC cord-005453-4057qib7 6896 18 aGvHD aGvHD NNP cord-005453-4057qib7 6896 19 , , , cord-005453-4057qib7 6896 20 which which WDT cord-005453-4057qib7 6896 21 was be VBD cord-005453-4057qib7 6896 22 observed observe VBN cord-005453-4057qib7 6896 23 in in IN cord-005453-4057qib7 6896 24 57.1 57.1 CD cord-005453-4057qib7 6896 25 % % NN cord-005453-4057qib7 6896 26 of of IN cord-005453-4057qib7 6896 27 pts pts NN cord-005453-4057qib7 6896 28 with with IN cord-005453-4057qib7 6896 29 severe severe JJ cord-005453-4057qib7 6896 30 NT NT NNP cord-005453-4057qib7 6896 31 , , , cord-005453-4057qib7 6896 32 compared compare VBN cord-005453-4057qib7 6896 33 to to IN cord-005453-4057qib7 6896 34 an an DT cord-005453-4057qib7 6896 35 overall overall JJ cord-005453-4057qib7 6896 36 aGvHD agvhd NN cord-005453-4057qib7 6896 37 rate rate NN cord-005453-4057qib7 6896 38 of of IN cord-005453-4057qib7 6896 39 30 30 CD cord-005453-4057qib7 6896 40 % % NN cord-005453-4057qib7 6896 41 . . . cord-005453-4057qib7 6897 1 Disclosure disclosure NN cord-005453-4057qib7 6897 2 : : : cord-005453-4057qib7 6897 3 Nothing nothing NN cord-005453-4057qib7 6897 4 to to TO cord-005453-4057qib7 6897 5 declare declare VB cord-005453-4057qib7 6897 6 Background background NN cord-005453-4057qib7 6897 7 : : : cord-005453-4057qib7 6897 8 Matched match VBN cord-005453-4057qib7 6897 9 - - HYPH cord-005453-4057qib7 6897 10 related relate VBN cord-005453-4057qib7 6897 11 bone bone NN cord-005453-4057qib7 6897 12 marrow marrow NN cord-005453-4057qib7 6897 13 transplantation transplantation NN cord-005453-4057qib7 6897 14 ( ( -LRB- cord-005453-4057qib7 6897 15 BMT BMT NNP cord-005453-4057qib7 6897 16 ) ) -RRB- cord-005453-4057qib7 6897 17 may may MD cord-005453-4057qib7 6897 18 cure cure VB cord-005453-4057qib7 6897 19 over over IN cord-005453-4057qib7 6897 20 80 80 CD cord-005453-4057qib7 6897 21 % % NN cord-005453-4057qib7 6897 22 of of IN cord-005453-4057qib7 6897 23 low low JJ cord-005453-4057qib7 6897 24 - - HYPH cord-005453-4057qib7 6897 25 riskchildren riskchildren NN cord-005453-4057qib7 6897 26 with with IN cord-005453-4057qib7 6897 27 severe severe JJ cord-005453-4057qib7 6897 28 thalassemia thalassemia NN cord-005453-4057qib7 6897 29 ( ( -LRB- cord-005453-4057qib7 6897 30 ST ST NNP cord-005453-4057qib7 6897 31 ) ) -RRB- cord-005453-4057qib7 6897 32 defined define VBD cord-005453-4057qib7 6897 33 as as IN cord-005453-4057qib7 6897 34 a a DT cord-005453-4057qib7 6897 35 thalassemia thalassemia NN cord-005453-4057qib7 6897 36 syndrome syndrome NN cord-005453-4057qib7 6897 37 with with IN cord-005453-4057qib7 6897 38 inability inability NN cord-005453-4057qib7 6897 39 to to TO cord-005453-4057qib7 6897 40 keep keep VB cord-005453-4057qib7 6897 41 a a DT cord-005453-4057qib7 6897 42 spontaneous spontaneous JJ cord-005453-4057qib7 6897 43 hemoglobin hemoglobin NN cord-005453-4057qib7 6897 44 > > SYM cord-005453-4057qib7 6897 45 7 7 CD cord-005453-4057qib7 6897 46 g g NN cord-005453-4057qib7 6897 47 / / SYM cord-005453-4057qib7 6897 48 dL. dL. NNS cord-005453-4057qib7 6898 1 It -PRON- PRP cord-005453-4057qib7 6898 2 is be VBZ cord-005453-4057qib7 6898 3 well well RB cord-005453-4057qib7 6898 4 known know VBN cord-005453-4057qib7 6898 5 that that DT cord-005453-4057qib7 6898 6 patient patient JJ cord-005453-4057qib7 6898 7 status status NN cord-005453-4057qib7 6898 8 at at IN cord-005453-4057qib7 6898 9 the the DT cord-005453-4057qib7 6898 10 time time NN cord-005453-4057qib7 6898 11 of of IN cord-005453-4057qib7 6898 12 transplant transplant NN cord-005453-4057qib7 6898 13 is be VBZ cord-005453-4057qib7 6898 14 critical critical JJ cord-005453-4057qib7 6898 15 in in IN cord-005453-4057qib7 6898 16 predicting predict VBG cord-005453-4057qib7 6898 17 transplant transplant NN cord-005453-4057qib7 6898 18 outcome outcome NN cord-005453-4057qib7 6898 19 . . . cord-005453-4057qib7 6899 1 Liver liver NN cord-005453-4057qib7 6899 2 size size NN cord-005453-4057qib7 6899 3 > > XX cord-005453-4057qib7 6899 4 2 2 CD cord-005453-4057qib7 6899 5 cm cm NN cord-005453-4057qib7 6899 6 is be VBZ cord-005453-4057qib7 6899 7 an an DT cord-005453-4057qib7 6899 8 established establish VBN cord-005453-4057qib7 6899 9 adverse adverse JJ cord-005453-4057qib7 6899 10 prognostic prognostic JJ cord-005453-4057qib7 6899 11 factor factor NN cord-005453-4057qib7 6899 12 in in IN cord-005453-4057qib7 6899 13 terms term NNS cord-005453-4057qib7 6899 14 of of IN cord-005453-4057qib7 6899 15 transplant transplant NN cord-005453-4057qib7 6899 16 - - HYPH cord-005453-4057qib7 6899 17 related relate VBN cord-005453-4057qib7 6899 18 mortality mortality NN cord-005453-4057qib7 6899 19 and and CC cord-005453-4057qib7 6899 20 , , , cord-005453-4057qib7 6899 21 in in IN cord-005453-4057qib7 6899 22 our -PRON- PRP$ cord-005453-4057qib7 6899 23 own own JJ cord-005453-4057qib7 6899 24 experience experience NN cord-005453-4057qib7 6899 25 , , , cord-005453-4057qib7 6899 26 a a DT cord-005453-4057qib7 6899 27 spleen spleen NN cord-005453-4057qib7 6899 28 size size NN cord-005453-4057qib7 6899 29 > > XX cord-005453-4057qib7 6899 30 3 3 CD cord-005453-4057qib7 6899 31 cm cm NN cord-005453-4057qib7 6899 32 from from IN cord-005453-4057qib7 6899 33 costal costal JJ cord-005453-4057qib7 6899 34 marginis marginis NNP cord-005453-4057qib7 6899 35 associated associate VBN cord-005453-4057qib7 6899 36 with with IN cord-005453-4057qib7 6899 37 increase increase NN cord-005453-4057qib7 6899 38 rejection rejection NN cord-005453-4057qib7 6899 39 rates rate NNS cord-005453-4057qib7 6899 40 ( ( -LRB- cord-005453-4057qib7 6899 41 Blood blood NN cord-005453-4057qib7 6899 42 2017 2017 CD cord-005453-4057qib7 6899 43 vol vol NN cord-005453-4057qib7 6899 44 . . . cord-005453-4057qib7 6900 1 130 130 CD cord-005453-4057qib7 6900 2 no no UH cord-005453-4057qib7 6900 3 . . . cord-005453-4057qib7 6901 1 Suppl Suppl NNP cord-005453-4057qib7 6901 2 1 1 CD cord-005453-4057qib7 6901 3 1944 1944 CD cord-005453-4057qib7 6901 4 ) ) -RRB- cord-005453-4057qib7 6901 5 . . . cord-005453-4057qib7 6902 1 Optimising optimise VBG cord-005453-4057qib7 6902 2 liver liver NN cord-005453-4057qib7 6902 3 and and CC cord-005453-4057qib7 6902 4 spleen spleen NN cord-005453-4057qib7 6902 5 size size NN cord-005453-4057qib7 6902 6 prior prior RB cord-005453-4057qib7 6902 7 to to IN cord-005453-4057qib7 6902 8 transplant transplant NN cord-005453-4057qib7 6902 9 is be VBZ cord-005453-4057qib7 6902 10 likely likely JJ cord-005453-4057qib7 6902 11 to to TO cord-005453-4057qib7 6902 12 improve improve VB cord-005453-4057qib7 6902 13 transplant transplant NN cord-005453-4057qib7 6902 14 outcomes outcome NNS cord-005453-4057qib7 6902 15 . . . cord-005453-4057qib7 6903 1 Methods method NNS cord-005453-4057qib7 6903 2 : : : cord-005453-4057qib7 6903 3 We -PRON- PRP cord-005453-4057qib7 6903 4 retrospectively retrospectively RB cord-005453-4057qib7 6903 5 reviewed review VBD cord-005453-4057qib7 6903 6 the the DT cord-005453-4057qib7 6903 7 effectiveness effectiveness NN cord-005453-4057qib7 6903 8 of of IN cord-005453-4057qib7 6903 9 our -PRON- PRP$ cord-005453-4057qib7 6903 10 strategy strategy NN cord-005453-4057qib7 6903 11 to to TO cord-005453-4057qib7 6903 12 reduce reduce VB cord-005453-4057qib7 6903 13 liver liver NN cord-005453-4057qib7 6903 14 and and CC cord-005453-4057qib7 6903 15 spleen spleen NN cord-005453-4057qib7 6903 16 size size NN cord-005453-4057qib7 6903 17 pre pre NN cord-005453-4057qib7 6903 18 - - NN cord-005453-4057qib7 6903 19 transplant transplant JJ cord-005453-4057qib7 6903 20 using use VBG cord-005453-4057qib7 6903 21 hydroxyurea hydroxyurea NNP cord-005453-4057qib7 6903 22 , , , cord-005453-4057qib7 6903 23 super super JJ cord-005453-4057qib7 6903 24 - - JJ cord-005453-4057qib7 6903 25 transfusion transfusion NN cord-005453-4057qib7 6903 26 and and CC cord-005453-4057qib7 6903 27 intensive intensive JJ cord-005453-4057qib7 6903 28 iron iron NN cord-005453-4057qib7 6903 29 chelation chelation NN cord-005453-4057qib7 6903 30 . . . cord-005453-4057qib7 6904 1 We -PRON- PRP cord-005453-4057qib7 6904 2 considered consider VBD cord-005453-4057qib7 6904 3 liver liver NN cord-005453-4057qib7 6904 4 size size NN cord-005453-4057qib7 6904 5 < < XX cord-005453-4057qib7 6904 6 2 2 CD cord-005453-4057qib7 6904 7 cm cm NNS cord-005453-4057qib7 6904 8 and and CC cord-005453-4057qib7 6904 9 spleen spleen NN cord-005453-4057qib7 6904 10 size size NN cord-005453-4057qib7 6904 11 less less JJR cord-005453-4057qib7 6904 12 than than IN cord-005453-4057qib7 6904 13 3 3 CD cord-005453-4057qib7 6904 14 cm cm NNS cord-005453-4057qib7 6904 15 below below IN cord-005453-4057qib7 6904 16 costal costal JJ cord-005453-4057qib7 6904 17 margins margin NNS cord-005453-4057qib7 6904 18 as as IN cord-005453-4057qib7 6904 19 good good JJ cord-005453-4057qib7 6904 20 risk risk NN cord-005453-4057qib7 6904 21 features feature NNS cord-005453-4057qib7 6904 22 . . . cord-005453-4057qib7 6905 1 Liver liver NN cord-005453-4057qib7 6905 2 biopsies biopsy NNS cord-005453-4057qib7 6905 3 were be VBD cord-005453-4057qib7 6905 4 not not RB cord-005453-4057qib7 6905 5 performed perform VBN cord-005453-4057qib7 6905 6 thus thus RB cord-005453-4057qib7 6905 7 Pesaro Pesaro NNP cord-005453-4057qib7 6905 8 risk risk NN cord-005453-4057qib7 6905 9 classification classification NN cord-005453-4057qib7 6905 10 could could MD cord-005453-4057qib7 6905 11 not not RB cord-005453-4057qib7 6905 12 be be VB cord-005453-4057qib7 6905 13 assigned assign VBN cord-005453-4057qib7 6905 14 . . . cord-005453-4057qib7 6906 1 All all DT cord-005453-4057qib7 6906 2 transplant transplant NN cord-005453-4057qib7 6906 3 candidates candidate NNS cord-005453-4057qib7 6906 4 were be VBD cord-005453-4057qib7 6906 5 started start VBN cord-005453-4057qib7 6906 6 on on IN cord-005453-4057qib7 6906 7 hydroxyurea hydroxyurea NNP cord-005453-4057qib7 6906 8 for for IN cord-005453-4057qib7 6906 9 a a DT cord-005453-4057qib7 6906 10 minimum minimum NN cord-005453-4057qib7 6906 11 of of IN cord-005453-4057qib7 6906 12 3 3 CD cord-005453-4057qib7 6906 13 months month NNS cord-005453-4057qib7 6906 14 and and CC cord-005453-4057qib7 6906 15 pre pre JJ cord-005453-4057qib7 6906 16 - - JJ cord-005453-4057qib7 6906 17 transfusion transfusion JJ cord-005453-4057qib7 6906 18 haemoglobin haemoglobin NN cord-005453-4057qib7 6906 19 was be VBD cord-005453-4057qib7 6906 20 maintained maintain VBN cord-005453-4057qib7 6906 21 > > XX cord-005453-4057qib7 6907 1 7 7 CD cord-005453-4057qib7 6907 2 gm gm NNP cord-005453-4057qib7 6907 3 / / SYM cord-005453-4057qib7 6907 4 dl dl NN cord-005453-4057qib7 6908 1 while while IN cord-005453-4057qib7 6908 2 on on IN cord-005453-4057qib7 6908 3 hydroxyurea hydroxyurea NNP cord-005453-4057qib7 6908 4 . . . cord-005453-4057qib7 6909 1 If if IN cord-005453-4057qib7 6909 2 the the DT cord-005453-4057qib7 6909 3 child child NN cord-005453-4057qib7 6909 4 had have VBD cord-005453-4057qib7 6909 5 hepatospenomegaly hepatospenomegaly NNP cord-005453-4057qib7 6909 6 at at IN cord-005453-4057qib7 6909 7 enrollmentand enrollmentand , cord-005453-4057qib7 6909 8 no no DT cord-005453-4057qib7 6909 9 improvement improvement NN cord-005453-4057qib7 6909 10 in in IN cord-005453-4057qib7 6909 11 liver liver NN cord-005453-4057qib7 6909 12 and and CC cord-005453-4057qib7 6909 13 spleen spleen NN cord-005453-4057qib7 6909 14 size size NN cord-005453-4057qib7 6909 15 after after IN cord-005453-4057qib7 6909 16 an an DT cord-005453-4057qib7 6909 17 adequate adequate JJ cord-005453-4057qib7 6909 18 trial trial NN cord-005453-4057qib7 6909 19 of of IN cord-005453-4057qib7 6909 20 hydroxyurea hydroxyurea NNP cord-005453-4057qib7 6909 21 ( ( -LRB- cord-005453-4057qib7 6909 22 minimum minimum NN cord-005453-4057qib7 6909 23 of of IN cord-005453-4057qib7 6909 24 3 3 CD cord-005453-4057qib7 6909 25 months month NNS cord-005453-4057qib7 6909 26 of of IN cord-005453-4057qib7 6909 27 treatment treatment NN cord-005453-4057qib7 6909 28 achieving achieve VBG cord-005453-4057qib7 6909 29 maximum maximum JJ cord-005453-4057qib7 6909 30 dose dose NN cord-005453-4057qib7 6909 31 of of IN cord-005453-4057qib7 6909 32 50 50 CD cord-005453-4057qib7 6909 33 mg mg NNP cord-005453-4057qib7 6909 34 / / SYM cord-005453-4057qib7 6909 35 kg kg NNP cord-005453-4057qib7 6909 36 day day NN cord-005453-4057qib7 6909 37 or or CC cord-005453-4057qib7 6909 38 tolerable tolerable JJ cord-005453-4057qib7 6909 39 haematological haematological JJ cord-005453-4057qib7 6909 40 toxicity toxicity NN cord-005453-4057qib7 6909 41 , , , cord-005453-4057qib7 6909 42 i.e. i.e. FW cord-005453-4057qib7 6909 43 neutrophil neutrophil NN cord-005453-4057qib7 6909 44 count count NN cord-005453-4057qib7 6909 45 between between IN cord-005453-4057qib7 6909 46 1000 1000 CD cord-005453-4057qib7 6909 47 and and CC cord-005453-4057qib7 6909 48 1500/ 1500/ CD cord-005453-4057qib7 6910 1 μL μL . cord-005453-4057qib7 6911 1 and/or and/or CC cord-005453-4057qib7 6911 2 platelet platelet NN cord-005453-4057qib7 6911 3 count count NN cord-005453-4057qib7 6911 4 between between IN cord-005453-4057qib7 6911 5 100.000 100.000 CD cord-005453-4057qib7 6911 6 and and CC cord-005453-4057qib7 6911 7 150.000 150.000 CD cord-005453-4057qib7 6912 1 /μL /μL NFP cord-005453-4057qib7 6912 2 ) ) -RRB- cord-005453-4057qib7 6912 3 patients patient NNS cord-005453-4057qib7 6912 4 were be VBD cord-005453-4057qib7 6912 5 given give VBN cord-005453-4057qib7 6912 6 a a DT cord-005453-4057qib7 6912 7 trial trial NN cord-005453-4057qib7 6912 8 of of IN cord-005453-4057qib7 6912 9 supertransfusion supertransfusion NN cord-005453-4057qib7 6912 10 maintaining maintain VBG cord-005453-4057qib7 6912 11 haemoglobin haemoglobin NN cord-005453-4057qib7 6912 12 above above IN cord-005453-4057qib7 6912 13 12 12 CD cord-005453-4057qib7 6912 14 g g NN cord-005453-4057qib7 6912 15 / / SYM cord-005453-4057qib7 6912 16 dL dl NN cord-005453-4057qib7 6912 17 ) ) -RRB- cord-005453-4057qib7 6912 18 for for IN cord-005453-4057qib7 6912 19 a a DT cord-005453-4057qib7 6912 20 minimum minimum NN cord-005453-4057qib7 6912 21 of of IN cord-005453-4057qib7 6912 22 3 3 CD cord-005453-4057qib7 6912 23 months month NNS cord-005453-4057qib7 6912 24 prior prior RB cord-005453-4057qib7 6912 25 to to IN cord-005453-4057qib7 6912 26 declaring declare VBG cord-005453-4057qib7 6912 27 the the DT cord-005453-4057qib7 6912 28 patient patient NN cord-005453-4057qib7 6912 29 as as IN cord-005453-4057qib7 6912 30 having have VBG cord-005453-4057qib7 6912 31 failed fail VBN cord-005453-4057qib7 6912 32 downstaging downstage VBG cord-005453-4057qib7 6912 33 . . . cord-005453-4057qib7 6913 1 Results result NNS cord-005453-4057qib7 6913 2 : : : cord-005453-4057qib7 6914 1 Out out IN cord-005453-4057qib7 6914 2 of of IN cord-005453-4057qib7 6914 3 119 119 CD cord-005453-4057qib7 6914 4 transplants transplant NNS cord-005453-4057qib7 6914 5 across across IN cord-005453-4057qib7 6914 6 3 3 CD cord-005453-4057qib7 6914 7 collaborating collaborate VBG cord-005453-4057qib7 6914 8 centers center NNS cord-005453-4057qib7 6914 9 in in IN cord-005453-4057qib7 6914 10 India India NNP cord-005453-4057qib7 6914 11 , , , cord-005453-4057qib7 6914 12 85 85 CD cord-005453-4057qib7 6914 13 patients patient NNS cord-005453-4057qib7 6914 14 had have VBD cord-005453-4057qib7 6914 15 no no DT cord-005453-4057qib7 6914 16 hepatosplenomegaly hepatosplenomegaly NNS cord-005453-4057qib7 6914 17 at at IN cord-005453-4057qib7 6914 18 enrolment enrolment NN cord-005453-4057qib7 6914 19 and and CC cord-005453-4057qib7 6914 20 hence hence RB cord-005453-4057qib7 6914 21 were be VBD cord-005453-4057qib7 6914 22 not not RB cord-005453-4057qib7 6914 23 actively actively RB cord-005453-4057qib7 6914 24 downstaged downstage VBN cord-005453-4057qib7 6914 25 . . . cord-005453-4057qib7 6915 1 Twelve twelve CD cord-005453-4057qib7 6915 2 patients patient NNS cord-005453-4057qib7 6915 3 were be VBD cord-005453-4057qib7 6915 4 excluded exclude VBN cord-005453-4057qib7 6915 5 due due IN cord-005453-4057qib7 6915 6 to to IN cord-005453-4057qib7 6915 7 inadequate inadequate JJ cord-005453-4057qib7 6915 8 information information NN cord-005453-4057qib7 6915 9 on on IN cord-005453-4057qib7 6915 10 their -PRON- PRP$ cord-005453-4057qib7 6915 11 records record NNS cord-005453-4057qib7 6915 12 . . . cord-005453-4057qib7 6916 1 All all DT cord-005453-4057qib7 6916 2 of of IN cord-005453-4057qib7 6916 3 the the DT cord-005453-4057qib7 6916 4 remaining remain VBG cord-005453-4057qib7 6916 5 22 22 CD cord-005453-4057qib7 6916 6 patients patient NNS cord-005453-4057qib7 6916 7 with with IN cord-005453-4057qib7 6916 8 enlarged enlarged JJ cord-005453-4057qib7 6916 9 liver liver NN cord-005453-4057qib7 6916 10 and/or and/or CC cord-005453-4057qib7 6916 11 spleen spleen NNS cord-005453-4057qib7 6916 12 were be VBD cord-005453-4057qib7 6916 13 downstaged downstage VBN cord-005453-4057qib7 6916 14 to to IN cord-005453-4057qib7 6916 15 low low JJ cord-005453-4057qib7 6916 16 - - HYPH cord-005453-4057qib7 6916 17 risk risk NN cord-005453-4057qib7 6916 18 features feature NNS cord-005453-4057qib7 6916 19 . . . cord-005453-4057qib7 6917 1 All all DT cord-005453-4057qib7 6917 2 patients patient NNS cord-005453-4057qib7 6917 3 received receive VBD cord-005453-4057qib7 6917 4 adequate adequate JJ cord-005453-4057qib7 6917 5 hydroxyurea hydroxyurea NN cord-005453-4057qib7 6917 6 trial trial NN cord-005453-4057qib7 6917 7 among among IN cord-005453-4057qib7 6917 8 which which WDT cord-005453-4057qib7 6917 9 seven seven CD cord-005453-4057qib7 6917 10 ( ( -LRB- cord-005453-4057qib7 6917 11 32 32 CD cord-005453-4057qib7 6917 12 % % NN cord-005453-4057qib7 6917 13 ) ) -RRB- cord-005453-4057qib7 6917 14 patients patient NNS cord-005453-4057qib7 6917 15 required require VBD cord-005453-4057qib7 6917 16 super super JJ cord-005453-4057qib7 6917 17 transfusion transfusion NN cord-005453-4057qib7 6917 18 in in IN cord-005453-4057qib7 6917 19 addition addition NN cord-005453-4057qib7 6917 20 to to IN cord-005453-4057qib7 6917 21 maximal maximal JJ cord-005453-4057qib7 6917 22 hydroxyurea hydroxyurea NN cord-005453-4057qib7 6917 23 . . . cord-005453-4057qib7 6918 1 Out out IN cord-005453-4057qib7 6918 2 of of IN cord-005453-4057qib7 6918 3 the the DT cord-005453-4057qib7 6918 4 22 22 CD cord-005453-4057qib7 6918 5 patients patient NNS cord-005453-4057qib7 6918 6 18 18 CD cord-005453-4057qib7 6918 7 ( ( -LRB- cord-005453-4057qib7 6918 8 82 82 CD cord-005453-4057qib7 6918 9 % % NN cord-005453-4057qib7 6918 10 ) ) -RRB- cord-005453-4057qib7 6918 11 were be VBD cord-005453-4057qib7 6918 12 successfully successfully RB cord-005453-4057qib7 6918 13 down down RB cord-005453-4057qib7 6918 14 - - HYPH cord-005453-4057qib7 6918 15 staged stage VBN cord-005453-4057qib7 6918 16 with with IN cord-005453-4057qib7 6918 17 the the DT cord-005453-4057qib7 6918 18 above above JJ cord-005453-4057qib7 6918 19 strategy strategy NN cord-005453-4057qib7 6918 20 and and CC cord-005453-4057qib7 6918 21 proceeded proceed VBD cord-005453-4057qib7 6918 22 to to TO cord-005453-4057qib7 6918 23 transplant transplant VB cord-005453-4057qib7 6918 24 as as RB cord-005453-4057qib7 6918 25 low low JJ cord-005453-4057qib7 6918 26 - - HYPH cord-005453-4057qib7 6918 27 risk risk NN cord-005453-4057qib7 6918 28 patients patient NNS cord-005453-4057qib7 6918 29 . . . cord-005453-4057qib7 6919 1 Among among IN cord-005453-4057qib7 6919 2 the the DT cord-005453-4057qib7 6919 3 remaining remain VBG cord-005453-4057qib7 6919 4 4 4 CD cord-005453-4057qib7 6919 5 ( ( -LRB- cord-005453-4057qib7 6919 6 25 25 CD cord-005453-4057qib7 6919 7 % % NN cord-005453-4057qib7 6919 8 ) ) -RRB- cord-005453-4057qib7 6919 9 patients patient NNS cord-005453-4057qib7 6919 10 3 3 CD cord-005453-4057qib7 6919 11 had have VBD cord-005453-4057qib7 6919 12 liver liver NN cord-005453-4057qib7 6919 13 > > XX cord-005453-4057qib7 6919 14 2 2 CD cord-005453-4057qib7 6919 15 cm cm NNS cord-005453-4057qib7 6919 16 and and CC cord-005453-4057qib7 6919 17 one one CD cord-005453-4057qib7 6919 18 had have VBD cord-005453-4057qib7 6919 19 a a DT cord-005453-4057qib7 6919 20 spleen spleen NN cord-005453-4057qib7 6919 21 > > XX cord-005453-4057qib7 6920 1 3 3 CD cord-005453-4057qib7 6920 2 cm cm NNS cord-005453-4057qib7 6920 3 only only RB cord-005453-4057qib7 6920 4 . . . cord-005453-4057qib7 6921 1 There there EX cord-005453-4057qib7 6921 2 was be VBD cord-005453-4057qib7 6921 3 significant significant JJ cord-005453-4057qib7 6921 4 improvement improvement NN cord-005453-4057qib7 6921 5 in in IN cord-005453-4057qib7 6921 6 liver liver NN cord-005453-4057qib7 6921 7 and and CC cord-005453-4057qib7 6921 8 spleen spleen NN cord-005453-4057qib7 6921 9 size size NN cord-005453-4057qib7 6921 10 from from IN cord-005453-4057qib7 6921 11 the the DT cord-005453-4057qib7 6921 12 time time NN cord-005453-4057qib7 6921 13 of of IN cord-005453-4057qib7 6921 14 enrollment enrollment NN cord-005453-4057qib7 6921 15 to to IN cord-005453-4057qib7 6921 16 transplant transplant NN cord-005453-4057qib7 6921 17 ( ( -LRB- cord-005453-4057qib7 6921 18 p p IN cord-005453-4057qib7 6921 19 value value NN cord-005453-4057qib7 6921 20 0.0004 0.0004 CD cord-005453-4057qib7 6921 21 and and CC cord-005453-4057qib7 6921 22 0.0002 0.0002 CD cord-005453-4057qib7 6921 23 respectively respectively RB cord-005453-4057qib7 6921 24 by by IN cord-005453-4057qib7 6921 25 Wilcoxon Wilcoxon NNP cord-005453-4057qib7 6921 26 test test NN cord-005453-4057qib7 6921 27 for for IN cord-005453-4057qib7 6921 28 paired pair VBN cord-005453-4057qib7 6921 29 samples sample NNS cord-005453-4057qib7 6921 30 -two -two ADD cord-005453-4057qib7 6921 31 tailed tail VBN cord-005453-4057qib7 6921 32 ) ) -RRB- cord-005453-4057qib7 6921 33 with with IN cord-005453-4057qib7 6921 34 median median JJ cord-005453-4057qib7 6921 35 duration duration NN cord-005453-4057qib7 6921 36 of of IN cord-005453-4057qib7 6921 37 downstaging downstaging NN cord-005453-4057qib7 6921 38 of of IN cord-005453-4057qib7 6921 39 9 9 CD cord-005453-4057qib7 6921 40 months month NNS cord-005453-4057qib7 6922 1 ( ( -LRB- cord-005453-4057qib7 6922 2 range range NNP cord-005453-4057qib7 6922 3 2 2 CD cord-005453-4057qib7 6922 4 - - SYM cord-005453-4057qib7 6922 5 27 27 CD cord-005453-4057qib7 6922 6 months month NNS cord-005453-4057qib7 6922 7 ) ) -RRB- cord-005453-4057qib7 6922 8 . . . cord-005453-4057qib7 6923 1 There there EX cord-005453-4057qib7 6923 2 was be VBD cord-005453-4057qib7 6923 3 no no DT cord-005453-4057qib7 6923 4 significant significant JJ cord-005453-4057qib7 6923 5 difference difference NN cord-005453-4057qib7 6923 6 in in IN cord-005453-4057qib7 6923 7 Overall overall JJ cord-005453-4057qib7 6923 8 survival survival NN cord-005453-4057qib7 6923 9 ( ( -LRB- cord-005453-4057qib7 6923 10 OS OS NNP cord-005453-4057qib7 6923 11 ) ) -RRB- cord-005453-4057qib7 6923 12 and and CC cord-005453-4057qib7 6923 13 Disease Disease NNP cord-005453-4057qib7 6923 14 - - HYPH cord-005453-4057qib7 6923 15 Free Free NNP cord-005453-4057qib7 6923 16 Survival Survival NNP cord-005453-4057qib7 6923 17 ( ( -LRB- cord-005453-4057qib7 6923 18 DFS DFS NNP cord-005453-4057qib7 6923 19 ) ) -RRB- cord-005453-4057qib7 6923 20 by by IN cord-005453-4057qib7 6923 21 log log NN cord-005453-4057qib7 6923 22 rank rank NN cord-005453-4057qib7 6923 23 test test NN cord-005453-4057qib7 6923 24 between between IN cord-005453-4057qib7 6923 25 the the DT cord-005453-4057qib7 6923 26 downstaged downstaged JJ cord-005453-4057qib7 6923 27 group group NN cord-005453-4057qib7 6923 28 and and CC cord-005453-4057qib7 6923 29 those those DT cord-005453-4057qib7 6923 30 who who WP cord-005453-4057qib7 6923 31 did do VBD cord-005453-4057qib7 6923 32 not not RB cord-005453-4057qib7 6923 33 have have VB cord-005453-4057qib7 6923 34 hepatosplenomegaly hepatosplenomegaly NNS cord-005453-4057qib7 6923 35 at at IN cord-005453-4057qib7 6923 36 enrollment enrollment NN cord-005453-4057qib7 6923 37 ( ( -LRB- cord-005453-4057qib7 6923 38 p p NN cord-005453-4057qib7 6923 39 value value NN cord-005453-4057qib7 6923 40 0.59 0.59 CD cord-005453-4057qib7 6923 41 0.64 0.64 CD cord-005453-4057qib7 6923 42 respectively respectively RB cord-005453-4057qib7 6923 43 ) ) -RRB- cord-005453-4057qib7 6923 44 . . . cord-005453-4057qib7 6924 1 Conclusions conclusion NNS cord-005453-4057qib7 6924 2 : : : cord-005453-4057qib7 6925 1 In in IN cord-005453-4057qib7 6925 2 the the DT cord-005453-4057qib7 6925 3 majority majority NN cord-005453-4057qib7 6925 4 of of IN cord-005453-4057qib7 6925 5 children child NNS cord-005453-4057qib7 6925 6 with with IN cord-005453-4057qib7 6925 7 thalassaemia thalassaemia NN cord-005453-4057qib7 6925 8 and and CC cord-005453-4057qib7 6925 9 high high JJ cord-005453-4057qib7 6925 10 transplant transplant NN cord-005453-4057qib7 6925 11 risk risk NN cord-005453-4057qib7 6925 12 features feature VBZ cord-005453-4057qib7 6926 1 liver liver NN cord-005453-4057qib7 6926 2 and and CC cord-005453-4057qib7 6926 3 spleen spleen NN cord-005453-4057qib7 6926 4 size size NN cord-005453-4057qib7 6926 5 can can MD cord-005453-4057qib7 6926 6 be be VB cord-005453-4057qib7 6926 7 reduced reduce VBN cord-005453-4057qib7 6927 1 pre pre JJ cord-005453-4057qib7 6927 2 - - NN cord-005453-4057qib7 6927 3 transplant transplant JJ cord-005453-4057qib7 6927 4 using use VBG cord-005453-4057qib7 6927 5 hydroxyurea hydroxyurea NNP cord-005453-4057qib7 6927 6 and and CC cord-005453-4057qib7 6927 7 supertransfusions supertransfusion NNS cord-005453-4057qib7 6927 8 thereby thereby RB cord-005453-4057qib7 6927 9 decreasing decrease VBG cord-005453-4057qib7 6927 10 transplant transplant NN cord-005453-4057qib7 6927 11 risk risk NN cord-005453-4057qib7 6927 12 . . . cord-005453-4057qib7 6928 1 Disclosure disclosure NN cord-005453-4057qib7 6928 2 : : : cord-005453-4057qib7 6928 3 Nothing nothing NN cord-005453-4057qib7 6928 4 to to TO cord-005453-4057qib7 6928 5 Declare declare VB cord-005453-4057qib7 6928 6 P316 p316 CD cord-005453-4057qib7 6928 7 Abstract Abstract NNP cord-005453-4057qib7 6928 8 already already RB cord-005453-4057qib7 6928 9 published publish VBN cord-005453-4057qib7 6928 10 . . . cord-005453-4057qib7 6929 1 Abstract Abstract NNP cord-005453-4057qib7 6929 2 withdrawn withdraw VBN cord-005453-4057qib7 6929 3 . . . cord-005453-4057qib7 6930 1 Longitudinal longitudinal JJ cord-005453-4057qib7 6930 2 analysis analysis NN cord-005453-4057qib7 6930 3 of of IN cord-005453-4057qib7 6930 4 the the DT cord-005453-4057qib7 6930 5 effect effect NN cord-005453-4057qib7 6930 6 of of IN cord-005453-4057qib7 6930 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 6930 8 cell cell NN cord-005453-4057qib7 6930 9 transplantation transplantation NN cord-005453-4057qib7 6930 10 on on IN cord-005453-4057qib7 6930 11 ocular ocular JJ cord-005453-4057qib7 6930 12 disease disease NN cord-005453-4057qib7 6930 13 in in IN cord-005453-4057qib7 6930 14 children child NNS cord-005453-4057qib7 6930 15 with with IN cord-005453-4057qib7 6930 16 mucopolysaccharidosis mucopolysaccharidosis NNP cord-005453-4057qib7 6931 1 i i PRP cord-005453-4057qib7 6931 2 shows show VBZ cord-005453-4057qib7 6931 3 ongoing ongoing JJ cord-005453-4057qib7 6931 4 disease disease NN cord-005453-4057qib7 6931 5 progression progression NN cord-005453-4057qib7 6931 6 Background background NN cord-005453-4057qib7 6931 7 : : : cord-005453-4057qib7 6931 8 Corneal corneal JJ cord-005453-4057qib7 6931 9 clouding clouding NN cord-005453-4057qib7 6931 10 is be VBZ cord-005453-4057qib7 6931 11 seen see VBN cord-005453-4057qib7 6931 12 in in IN cord-005453-4057qib7 6931 13 nearly nearly RB cord-005453-4057qib7 6931 14 all all DT cord-005453-4057qib7 6931 15 patients patient NNS cord-005453-4057qib7 6931 16 with with IN cord-005453-4057qib7 6931 17 Mucopolysaccharidosis-1 Mucopolysaccharidosis-1 NNP cord-005453-4057qib7 6931 18 ( ( -LRB- cord-005453-4057qib7 6931 19 MPS-1 MPS-1 NNP cord-005453-4057qib7 6931 20 ) ) -RRB- cord-005453-4057qib7 6931 21 causing cause VBG cord-005453-4057qib7 6931 22 visual visual JJ cord-005453-4057qib7 6931 23 impairment impairment NN cord-005453-4057qib7 6931 24 . . . cord-005453-4057qib7 6932 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 6932 2 cell cell NN cord-005453-4057qib7 6932 3 transplantation transplantation NN cord-005453-4057qib7 6932 4 ( ( -LRB- cord-005453-4057qib7 6932 5 HCT HCT NNP cord-005453-4057qib7 6932 6 ) ) -RRB- cord-005453-4057qib7 6932 7 is be VBZ cord-005453-4057qib7 6932 8 able able JJ cord-005453-4057qib7 6932 9 to to TO cord-005453-4057qib7 6932 10 stabilize stabilize VB cord-005453-4057qib7 6932 11 disease disease NN cord-005453-4057qib7 6932 12 in in IN cord-005453-4057qib7 6932 13 many many JJ cord-005453-4057qib7 6932 14 organs organ NNS cord-005453-4057qib7 6932 15 including include VBG cord-005453-4057qib7 6932 16 the the DT cord-005453-4057qib7 6932 17 brain brain NN cord-005453-4057qib7 6932 18 . . . cord-005453-4057qib7 6933 1 However however RB cord-005453-4057qib7 6933 2 , , , cord-005453-4057qib7 6933 3 residual residual JJ cord-005453-4057qib7 6933 4 disease disease NN cord-005453-4057qib7 6933 5 in in IN cord-005453-4057qib7 6933 6 peripheral peripheral JJ cord-005453-4057qib7 6933 7 tissues tissue NNS cord-005453-4057qib7 6933 8 is be VBZ cord-005453-4057qib7 6933 9 often often RB cord-005453-4057qib7 6933 10 described describe VBN cord-005453-4057qib7 6933 11 . . . cord-005453-4057qib7 6934 1 Therefore therefore RB cord-005453-4057qib7 6934 2 , , , cord-005453-4057qib7 6934 3 the the DT cord-005453-4057qib7 6934 4 aim aim NN cord-005453-4057qib7 6934 5 of of IN cord-005453-4057qib7 6934 6 this this DT cord-005453-4057qib7 6934 7 study study NN cord-005453-4057qib7 6934 8 was be VBD cord-005453-4057qib7 6934 9 to to TO cord-005453-4057qib7 6934 10 determine determine VB cord-005453-4057qib7 6934 11 the the DT cord-005453-4057qib7 6934 12 long long JJ cord-005453-4057qib7 6934 13 - - HYPH cord-005453-4057qib7 6934 14 term term NN cord-005453-4057qib7 6934 15 effect effect NN cord-005453-4057qib7 6934 16 of of IN cord-005453-4057qib7 6934 17 HCT hct NN cord-005453-4057qib7 6934 18 on on IN cord-005453-4057qib7 6934 19 ocular ocular JJ cord-005453-4057qib7 6934 20 disease disease NN cord-005453-4057qib7 6934 21 in in IN cord-005453-4057qib7 6934 22 MPS-1 MPS-1 NNP cord-005453-4057qib7 6934 23 patients patient NNS cord-005453-4057qib7 6934 24 . . . cord-005453-4057qib7 6935 1 Methods method NNS cord-005453-4057qib7 6935 2 : : : cord-005453-4057qib7 6935 3 Corneal corneal JJ cord-005453-4057qib7 6935 4 clouding clouding NN cord-005453-4057qib7 6935 5 ( ( -LRB- cord-005453-4057qib7 6935 6 grade grade NN cord-005453-4057qib7 6935 7 0 0 CD cord-005453-4057qib7 6935 8 - - SYM cord-005453-4057qib7 6935 9 4 4 CD cord-005453-4057qib7 6935 10 ) ) -RRB- cord-005453-4057qib7 6935 11 and and CC cord-005453-4057qib7 6935 12 visual visual JJ cord-005453-4057qib7 6935 13 acuity acuity NN cord-005453-4057qib7 6935 14 ( ( -LRB- cord-005453-4057qib7 6935 15 Decimal decimal JJ cord-005453-4057qib7 6935 16 scale scale NN cord-005453-4057qib7 6935 17 ) ) -RRB- cord-005453-4057qib7 6935 18 were be VBD cord-005453-4057qib7 6935 19 prospectively prospectively RB cord-005453-4057qib7 6935 20 collected collect VBN cord-005453-4057qib7 6935 21 from from IN cord-005453-4057qib7 6935 22 all all DT cord-005453-4057qib7 6935 23 consecutive consecutive JJ cord-005453-4057qib7 6935 24 MPS-1 MPS-1 NNP cord-005453-4057qib7 6935 25 patients patient NNS cord-005453-4057qib7 6935 26 treated treat VBN cord-005453-4057qib7 6935 27 with with IN cord-005453-4057qib7 6935 28 HCT hct NN cord-005453-4057qib7 6935 29 between between IN cord-005453-4057qib7 6935 30 2003 2003 CD cord-005453-4057qib7 6935 31 and and CC cord-005453-4057qib7 6935 32 2018 2018 CD cord-005453-4057qib7 6935 33 at at IN cord-005453-4057qib7 6935 34 the the DT cord-005453-4057qib7 6935 35 UMC UMC NNP cord-005453-4057qib7 6935 36 Utrecht Utrecht NNP cord-005453-4057qib7 6935 37 . . . cord-005453-4057qib7 6936 1 The the DT cord-005453-4057qib7 6936 2 primary primary JJ cord-005453-4057qib7 6936 3 outcomes outcome NNS cord-005453-4057qib7 6936 4 of of IN cord-005453-4057qib7 6936 5 interest interest NN cord-005453-4057qib7 6936 6 , , , cord-005453-4057qib7 6936 7 the the DT cord-005453-4057qib7 6936 8 effect effect NN cord-005453-4057qib7 6936 9 of of IN cord-005453-4057qib7 6936 10 time time NN cord-005453-4057qib7 6936 11 on on IN cord-005453-4057qib7 6936 12 corneal corneal JJ cord-005453-4057qib7 6936 13 clouding clouding NN cord-005453-4057qib7 6936 14 and and CC cord-005453-4057qib7 6936 15 visual visual JJ cord-005453-4057qib7 6936 16 acuity acuity NN cord-005453-4057qib7 6936 17 , , , cord-005453-4057qib7 6936 18 were be VBD cord-005453-4057qib7 6936 19 analyzed analyze VBN cord-005453-4057qib7 6936 20 using use VBG cord-005453-4057qib7 6936 21 a a DT cord-005453-4057qib7 6936 22 linear linear JJ cord-005453-4057qib7 6936 23 mixed mixed JJ cord-005453-4057qib7 6936 24 model model NN cord-005453-4057qib7 6936 25 . . . cord-005453-4057qib7 6937 1 The the DT cord-005453-4057qib7 6937 2 correlation correlation NN cord-005453-4057qib7 6937 3 between between IN cord-005453-4057qib7 6937 4 corneal corneal JJ cord-005453-4057qib7 6937 5 clouding clouding NN cord-005453-4057qib7 6937 6 and and CC cord-005453-4057qib7 6937 7 visual visual JJ cord-005453-4057qib7 6937 8 acuity acuity NN cord-005453-4057qib7 6937 9 was be VBD cord-005453-4057qib7 6937 10 analyzed analyze VBN cord-005453-4057qib7 6937 11 with with IN cord-005453-4057qib7 6937 12 Pearson Pearson NNP cord-005453-4057qib7 6937 13 's 's POS cord-005453-4057qib7 6937 14 rho rho NN cord-005453-4057qib7 6937 15 . . . cord-005453-4057qib7 6938 1 Other other JJ cord-005453-4057qib7 6938 2 parameters parameter NNS cord-005453-4057qib7 6938 3 studied study VBD cord-005453-4057qib7 6938 4 were be VBD cord-005453-4057qib7 6938 5 clinical clinical JJ cord-005453-4057qib7 6938 6 phenotype phenotype NN cord-005453-4057qib7 6938 7 , , , cord-005453-4057qib7 6938 8 age age NN cord-005453-4057qib7 6938 9 at at IN cord-005453-4057qib7 6938 10 time time NN cord-005453-4057qib7 6938 11 of of IN cord-005453-4057qib7 6939 1 transplantation transplantation NN cord-005453-4057qib7 6939 2 and and CC cord-005453-4057qib7 6939 3 hematological hematological JJ cord-005453-4057qib7 6939 4 enzyme enzyme NN cord-005453-4057qib7 6939 5 level level NN cord-005453-4057qib7 6939 6 after after IN cord-005453-4057qib7 6939 7 transplantation transplantation NN cord-005453-4057qib7 6939 8 . . . cord-005453-4057qib7 6940 1 Other other JJ cord-005453-4057qib7 6940 2 outcomes outcome NNS cord-005453-4057qib7 6940 3 of of IN cord-005453-4057qib7 6940 4 interest interest NN cord-005453-4057qib7 6940 5 analyzed analyze VBD cord-005453-4057qib7 6940 6 included include VBD cord-005453-4057qib7 6940 7 intra intra JJ cord-005453-4057qib7 6940 8 - - JJ cord-005453-4057qib7 6940 9 ocular ocular JJ cord-005453-4057qib7 6940 10 pressure pressure NN cord-005453-4057qib7 6940 11 , , , cord-005453-4057qib7 6940 12 refraction refraction NN cord-005453-4057qib7 6940 13 , , , cord-005453-4057qib7 6940 14 and and CC cord-005453-4057qib7 6940 15 macula macula NN cord-005453-4057qib7 6940 16 and and CC cord-005453-4057qib7 6940 17 lens lens NN cord-005453-4057qib7 6940 18 abnormalities abnormality NNS cord-005453-4057qib7 6940 19 . . . cord-005453-4057qib7 6941 1 [ [ -LRB- cord-005453-4057qib7 6941 2 [ [ -LRB- cord-005453-4057qib7 6941 3 P318 p318 CD cord-005453-4057qib7 6941 4 Image image NN cord-005453-4057qib7 6941 5 ] ] -RRB- cord-005453-4057qib7 6941 6 1 1 CD cord-005453-4057qib7 6941 7 . . . cord-005453-4057qib7 6942 1 Results result NNS cord-005453-4057qib7 6942 2 : : : cord-005453-4057qib7 6942 3 24 24 CD cord-005453-4057qib7 6942 4 successfully successfully RB cord-005453-4057qib7 6942 5 engrafted engraft VBN cord-005453-4057qib7 6942 6 MPS-1 MPS-1 NNP cord-005453-4057qib7 6942 7 patients patient NNS cord-005453-4057qib7 6942 8 were be VBD cord-005453-4057qib7 6942 9 included include VBN cord-005453-4057qib7 6942 10 ( ( -LRB- cord-005453-4057qib7 6942 11 92 92 CD cord-005453-4057qib7 6942 12 % % NN cord-005453-4057qib7 6942 13 with with IN cord-005453-4057qib7 6942 14 > > XX cord-005453-4057qib7 6942 15 95 95 CD cord-005453-4057qib7 6942 16 % % NN cord-005453-4057qib7 6942 17 chimerism chimerism NN cord-005453-4057qib7 6942 18 and and CC cord-005453-4057qib7 6942 19 normal normal JJ cord-005453-4057qib7 6942 20 enzyme enzyme NN cord-005453-4057qib7 6942 21 levels level NNS cord-005453-4057qib7 6942 22 after after IN cord-005453-4057qib7 6942 23 HCT HCT NNP cord-005453-4057qib7 6942 24 ) ) -RRB- cord-005453-4057qib7 6942 25 . . . cord-005453-4057qib7 6943 1 Corneal corneal JJ cord-005453-4057qib7 6943 2 clouding clouding NN cord-005453-4057qib7 6943 3 stabilized stabilize VBD cord-005453-4057qib7 6943 4 during during IN cord-005453-4057qib7 6943 5 the the DT cord-005453-4057qib7 6943 6 first first JJ cord-005453-4057qib7 6943 7 years year NNS cord-005453-4057qib7 6943 8 after after IN cord-005453-4057qib7 6943 9 HCT hct NN cord-005453-4057qib7 6943 10 , , , cord-005453-4057qib7 6943 11 but but CC cord-005453-4057qib7 6943 12 increased increase VBD cord-005453-4057qib7 6943 13 rapidly rapidly RB cord-005453-4057qib7 6943 14 beyond beyond IN cord-005453-4057qib7 6943 15 three three CD cord-005453-4057qib7 6943 16 years year NNS cord-005453-4057qib7 6943 17 ( ( -LRB- cord-005453-4057qib7 6943 18 figure figure NN cord-005453-4057qib7 6943 19 1 1 CD cord-005453-4057qib7 6943 20 ) ) -RRB- cord-005453-4057qib7 6943 21 . . . cord-005453-4057qib7 6944 1 Other other JJ cord-005453-4057qib7 6944 2 predictors predictor NNS cord-005453-4057qib7 6944 3 for for IN cord-005453-4057qib7 6944 4 increased increase VBN cord-005453-4057qib7 6944 5 corneal corneal JJ cord-005453-4057qib7 6944 6 clouding clouding NN cord-005453-4057qib7 6944 7 were be VBD cord-005453-4057qib7 6944 8 age age NN cord-005453-4057qib7 6944 9 at at IN cord-005453-4057qib7 6944 10 time time NN cord-005453-4057qib7 6944 11 of of IN cord-005453-4057qib7 6944 12 transplantation transplantation NN cord-005453-4057qib7 6944 13 ( ( -LRB- cord-005453-4057qib7 6944 14 0.74 0.74 CD cord-005453-4057qib7 6944 15 , , , cord-005453-4057qib7 6944 16 95%CI 95%ci CD cord-005453-4057qib7 6944 17 0.34:1.15 0.34:1.15 CD cord-005453-4057qib7 6944 18 ; ; : cord-005453-4057qib7 6944 19 p=0.0026 p=0.0026 VB cord-005453-4057qib7 6944 20 ) ) -RRB- cord-005453-4057qib7 6944 21 and and CC cord-005453-4057qib7 6944 22 clinical clinical JJ cord-005453-4057qib7 6944 23 phenotype phenotype NN cord-005453-4057qib7 6944 24 ( ( -LRB- cord-005453-4057qib7 6944 25 -1.02 -1.02 NFP cord-005453-4057qib7 6944 26 , , , cord-005453-4057qib7 6944 27 95%CI 95%ci CD cord-005453-4057qib7 6944 28 -0.18:-1.86 -0.18:-1.86 VBD cord-005453-4057qib7 6944 29 ; ; : cord-005453-4057qib7 6944 30 p=0.0335 p=0.0335 ADD cord-005453-4057qib7 6944 31 ) ) -RRB- cord-005453-4057qib7 6944 32 . . . cord-005453-4057qib7 6945 1 Visual visual JJ cord-005453-4057qib7 6945 2 acuity acuity NN cord-005453-4057qib7 6945 3 also also RB cord-005453-4057qib7 6945 4 worsened worsen VBD cord-005453-4057qib7 6945 5 significantly significantly RB cord-005453-4057qib7 6945 6 over over IN cord-005453-4057qib7 6945 7 time time NN cord-005453-4057qib7 6945 8 ( ( -LRB- cord-005453-4057qib7 6945 9 -0.03 -0.03 CD cord-005453-4057qib7 6945 10 , , , cord-005453-4057qib7 6945 11 95%CI 95%ci CD cord-005453-4057qib7 6945 12 -0.06:-0.007 -0.06:-0.007 NN cord-005453-4057qib7 6945 13 ; ; : cord-005453-4057qib7 6945 14 p=0.01 p=0.01 NNP cord-005453-4057qib7 6945 15 ) ) -RRB- cord-005453-4057qib7 6945 16 . . . cord-005453-4057qib7 6946 1 Corneal corneal JJ cord-005453-4057qib7 6946 2 clouding clouding NN cord-005453-4057qib7 6946 3 was be VBD cord-005453-4057qib7 6946 4 strongly strongly RB cord-005453-4057qib7 6946 5 negatively negatively RB cord-005453-4057qib7 6946 6 correlated correlate VBN cord-005453-4057qib7 6946 7 with with IN cord-005453-4057qib7 6946 8 visual visual JJ cord-005453-4057qib7 6946 9 acuity acuity NN cord-005453-4057qib7 6946 10 ( ( -LRB- cord-005453-4057qib7 6946 11 ρ ρ CD cord-005453-4057qib7 6946 12 -0.60 -0.60 CD cord-005453-4057qib7 6946 13 , , , cord-005453-4057qib7 6946 14 p p NN cord-005453-4057qib7 6946 15 = = SYM cord-005453-4057qib7 6946 16 7.12e-11 7.12e-11 CD cord-005453-4057qib7 6946 17 ) ) -RRB- cord-005453-4057qib7 6946 18 . . . cord-005453-4057qib7 6947 1 Conclusions conclusion NNS cord-005453-4057qib7 6947 2 : : : cord-005453-4057qib7 6948 1 After after IN cord-005453-4057qib7 6948 2 initial initial JJ cord-005453-4057qib7 6948 3 stabilization stabilization NN cord-005453-4057qib7 6948 4 , , , cord-005453-4057qib7 6948 5 ongoing ongoing JJ cord-005453-4057qib7 6948 6 ocular ocular JJ cord-005453-4057qib7 6948 7 disease disease NN cord-005453-4057qib7 6948 8 is be VBZ cord-005453-4057qib7 6948 9 seen see VBN cord-005453-4057qib7 6948 10 in in IN cord-005453-4057qib7 6948 11 MPS-1 MPS-1 NNP cord-005453-4057qib7 6948 12 patients patient NNS cord-005453-4057qib7 6948 13 despite despite IN cord-005453-4057qib7 6948 14 successful successful JJ cord-005453-4057qib7 6948 15 HCT hct NN cord-005453-4057qib7 6948 16 . . . cord-005453-4057qib7 6949 1 This this DT cord-005453-4057qib7 6949 2 hallmarks hallmark VBD cord-005453-4057qib7 6949 3 the the DT cord-005453-4057qib7 6949 4 shortcomings shortcoming NNS cord-005453-4057qib7 6949 5 of of IN cord-005453-4057qib7 6949 6 current current JJ cord-005453-4057qib7 6949 7 standard standard JJ cord-005453-4057qib7 6949 8 therapies therapy NNS cord-005453-4057qib7 6949 9 . . . cord-005453-4057qib7 6950 1 New new JJ cord-005453-4057qib7 6950 2 therapies therapy NNS cord-005453-4057qib7 6950 3 that that WDT cord-005453-4057qib7 6950 4 overcome overcome VBP cord-005453-4057qib7 6950 5 the the DT cord-005453-4057qib7 6950 6 weak weak JJ cord-005453-4057qib7 6950 7 spots spot NNS cord-005453-4057qib7 6950 8 of of IN cord-005453-4057qib7 6950 9 current current JJ cord-005453-4057qib7 6950 10 therapies therapy NNS cord-005453-4057qib7 6950 11 are be VBP cord-005453-4057qib7 6950 12 necessary necessary JJ cord-005453-4057qib7 6950 13 to to TO cord-005453-4057qib7 6950 14 improve improve VB cord-005453-4057qib7 6950 15 the the DT cord-005453-4057qib7 6950 16 late late JJ cord-005453-4057qib7 6950 17 outcomes outcome NNS cord-005453-4057qib7 6950 18 of of IN cord-005453-4057qib7 6950 19 these these DT cord-005453-4057qib7 6950 20 patients patient NNS cord-005453-4057qib7 6950 21 . . . cord-005453-4057qib7 6951 1 Clinical clinical JJ cord-005453-4057qib7 6951 2 Trial Trial NNP cord-005453-4057qib7 6951 3 Registry Registry NNP cord-005453-4057qib7 6951 4 : : : cord-005453-4057qib7 6952 1 N.A. N.A. NNP cord-005453-4057qib7 6952 2 Disclosure Disclosure NNP cord-005453-4057qib7 6952 3 : : : cord-005453-4057qib7 6953 1 B.T.A.v.d b.t.a.v.d RB cord-005453-4057qib7 6953 2 . . . cord-005453-4057qib7 6954 1 B. B. NNP cord-005453-4057qib7 6954 2 was be VBD cord-005453-4057qib7 6954 3 supported support VBN cord-005453-4057qib7 6954 4 by by IN cord-005453-4057qib7 6954 5 a a DT cord-005453-4057qib7 6954 6 research research NN cord-005453-4057qib7 6954 7 grant grant NN cord-005453-4057qib7 6954 8 from from IN cord-005453-4057qib7 6954 9 the the DT cord-005453-4057qib7 6954 10 Sylvia Sylvia NNP cord-005453-4057qib7 6954 11 Toth Toth NNP cord-005453-4057qib7 6954 12 Charity Charity NNP cord-005453-4057qib7 6954 13 Foundation Foundation NNP cord-005453-4057qib7 6954 14 , , , cord-005453-4057qib7 6954 15 the the DT cord-005453-4057qib7 6954 16 Hague Hague NNP cord-005453-4057qib7 6954 17 , , , cord-005453-4057qib7 6954 18 the the DT cord-005453-4057qib7 6954 19 Netherlands Netherlands NNP cord-005453-4057qib7 6954 20 , , , cord-005453-4057qib7 6954 21 while while IN cord-005453-4057qib7 6954 22 working work VBG cord-005453-4057qib7 6954 23 on on IN cord-005453-4057qib7 6954 24 this this DT cord-005453-4057qib7 6954 25 study study NN cord-005453-4057qib7 6954 26 . . . cord-005453-4057qib7 6955 1 The the DT cord-005453-4057qib7 6955 2 sponsors sponsor NNS cord-005453-4057qib7 6955 3 of of IN cord-005453-4057qib7 6955 4 this this DT cord-005453-4057qib7 6955 5 study study NN cord-005453-4057qib7 6955 6 are be VBP cord-005453-4057qib7 6955 7 public public JJ cord-005453-4057qib7 6955 8 or or CC cord-005453-4057qib7 6955 9 nonprofit nonprofit JJ cord-005453-4057qib7 6955 10 organizations organization NNS cord-005453-4057qib7 6955 11 that that WDT cord-005453-4057qib7 6955 12 support support VBP cord-005453-4057qib7 6955 13 science science NN cord-005453-4057qib7 6955 14 in in IN cord-005453-4057qib7 6955 15 general general JJ cord-005453-4057qib7 6955 16 . . . cord-005453-4057qib7 6956 1 They -PRON- PRP cord-005453-4057qib7 6956 2 had have VBD cord-005453-4057qib7 6956 3 no no DT cord-005453-4057qib7 6956 4 role role NN cord-005453-4057qib7 6956 5 in in IN cord-005453-4057qib7 6956 6 gathering gathering NN cord-005453-4057qib7 6956 7 , , , cord-005453-4057qib7 6956 8 analyzing analyze VBG cord-005453-4057qib7 6956 9 , , , cord-005453-4057qib7 6956 10 or or CC cord-005453-4057qib7 6956 11 interpreting interpret VBG cord-005453-4057qib7 6956 12 the the DT cord-005453-4057qib7 6956 13 data datum NNS cord-005453-4057qib7 6956 14 . . . cord-005453-4057qib7 6957 1 All all DT cord-005453-4057qib7 6957 2 authors author NNS cord-005453-4057qib7 6957 3 would would MD cord-005453-4057qib7 6957 4 like like VB cord-005453-4057qib7 6957 5 to to TO cord-005453-4057qib7 6957 6 thank thank VB cord-005453-4057qib7 6957 7 all all DT cord-005453-4057qib7 6957 8 parents parent NNS cord-005453-4057qib7 6957 9 and and CC cord-005453-4057qib7 6957 10 patients patient NNS cord-005453-4057qib7 6957 11 for for IN cord-005453-4057qib7 6957 12 participating participate VBG cord-005453-4057qib7 6957 13 in in IN cord-005453-4057qib7 6957 14 this this DT cord-005453-4057qib7 6957 15 study study NN cord-005453-4057qib7 6957 16 . . . cord-005453-4057qib7 6958 1 All all DT cord-005453-4057qib7 6958 2 authors author NNS cord-005453-4057qib7 6958 3 state state VBP cord-005453-4057qib7 6959 1 they -PRON- PRP cord-005453-4057qib7 6959 2 have have VBP cord-005453-4057qib7 6959 3 no no DT cord-005453-4057qib7 6959 4 competitive competitive JJ cord-005453-4057qib7 6959 5 ( ( -LRB- cord-005453-4057qib7 6959 6 financial financial JJ cord-005453-4057qib7 6959 7 ) ) -RRB- cord-005453-4057qib7 6959 8 interests interest NNS cord-005453-4057qib7 6959 9 in in IN cord-005453-4057qib7 6959 10 this this DT cord-005453-4057qib7 6959 11 study study NN cord-005453-4057qib7 6959 12 . . . cord-005453-4057qib7 6960 1 Background background NN cord-005453-4057qib7 6960 2 : : : cord-005453-4057qib7 6961 1 Paroxysmal Paroxysmal NNP cord-005453-4057qib7 6961 2 nocturnal nocturnal JJ cord-005453-4057qib7 6961 3 hemoglobinuria hemoglobinuria NN cord-005453-4057qib7 6961 4 ( ( -LRB- cord-005453-4057qib7 6961 5 PNH PNH NNP cord-005453-4057qib7 6961 6 ) ) -RRB- cord-005453-4057qib7 6961 7 is be VBZ cord-005453-4057qib7 6961 8 an an DT cord-005453-4057qib7 6961 9 acquired acquire VBN cord-005453-4057qib7 6961 10 clonal clonal JJ cord-005453-4057qib7 6961 11 disorder disorder NN cord-005453-4057qib7 6961 12 of of IN cord-005453-4057qib7 6961 13 the the DT cord-005453-4057qib7 6961 14 hemopoietic hemopoietic JJ cord-005453-4057qib7 6961 15 stem stem NN cord-005453-4057qib7 6961 16 cells cell NNS cord-005453-4057qib7 6961 17 for for IN cord-005453-4057qib7 6961 18 which which WDT cord-005453-4057qib7 6961 19 the the DT cord-005453-4057qib7 6961 20 only only JJ cord-005453-4057qib7 6961 21 curative curative JJ cord-005453-4057qib7 6961 22 treatment treatment NN cord-005453-4057qib7 6961 23 is be VBZ cord-005453-4057qib7 6961 24 allogeneic allogeneic VBG cord-005453-4057qib7 6961 25 hematopoietic hematopoietic JJ cord-005453-4057qib7 6961 26 stem stem NN cord-005453-4057qib7 6961 27 cell cell NN cord-005453-4057qib7 6961 28 transplantation transplantation NN cord-005453-4057qib7 6961 29 . . . cord-005453-4057qib7 6962 1 Haploidentical haploidentical JJ cord-005453-4057qib7 6962 2 donor donor NN cord-005453-4057qib7 6962 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 6962 4 stem stem NN cord-005453-4057qib7 6962 5 cell cell NN cord-005453-4057qib7 6962 6 transplantation transplantation NN cord-005453-4057qib7 6962 7 ( ( -LRB- cord-005453-4057qib7 6962 8 haplo haplo NNP cord-005453-4057qib7 6962 9 - - HYPH cord-005453-4057qib7 6962 10 HSCT HSCT NNP cord-005453-4057qib7 6962 11 ) ) -RRB- cord-005453-4057qib7 6962 12 is be VBZ cord-005453-4057qib7 6962 13 now now RB cord-005453-4057qib7 6962 14 increasingly increasingly RB cord-005453-4057qib7 6962 15 applied apply VBN cord-005453-4057qib7 6962 16 as as IN cord-005453-4057qib7 6962 17 a a DT cord-005453-4057qib7 6962 18 curative curative JJ cord-005453-4057qib7 6962 19 therapy therapy NN cord-005453-4057qib7 6962 20 for for IN cord-005453-4057qib7 6962 21 patients patient NNS cord-005453-4057qib7 6962 22 with with IN cord-005453-4057qib7 6962 23 hematologic hematologic JJ cord-005453-4057qib7 6962 24 diseases disease NNS cord-005453-4057qib7 6962 25 . . . cord-005453-4057qib7 6963 1 However however RB cord-005453-4057qib7 6963 2 , , , cord-005453-4057qib7 6963 3 there there EX cord-005453-4057qib7 6963 4 are be VBP cord-005453-4057qib7 6963 5 still still RB cord-005453-4057qib7 6963 6 few few JJ cord-005453-4057qib7 6963 7 reports report NNS cord-005453-4057qib7 6963 8 on on IN cord-005453-4057qib7 6963 9 the the DT cord-005453-4057qib7 6963 10 use use NN cord-005453-4057qib7 6963 11 of of IN cord-005453-4057qib7 6963 12 haplo haplo NNP cord-005453-4057qib7 6963 13 - - HYPH cord-005453-4057qib7 6963 14 HSCT HSCT NNP cord-005453-4057qib7 6963 15 for for IN cord-005453-4057qib7 6963 16 the the DT cord-005453-4057qib7 6963 17 treatment treatment NN cord-005453-4057qib7 6963 18 of of IN cord-005453-4057qib7 6963 19 PNH PNH NNP cord-005453-4057qib7 6963 20 . . . cord-005453-4057qib7 6964 1 Our -PRON- PRP$ cord-005453-4057qib7 6964 2 study study NN cord-005453-4057qib7 6964 3 aimed aim VBD cord-005453-4057qib7 6964 4 to to TO cord-005453-4057qib7 6964 5 compare compare VB cord-005453-4057qib7 6964 6 the the DT cord-005453-4057qib7 6964 7 outcomes outcome NNS cord-005453-4057qib7 6964 8 of of IN cord-005453-4057qib7 6964 9 haplo haplo NN cord-005453-4057qib7 6964 10 - - HYPH cord-005453-4057qib7 6964 11 HSCT HSCT NNP cord-005453-4057qib7 6964 12 with with IN cord-005453-4057qib7 6964 13 matched match VBN cord-005453-4057qib7 6964 14 - - HYPH cord-005453-4057qib7 6964 15 sibling sibling NN cord-005453-4057qib7 6964 16 donor donor NN cord-005453-4057qib7 6964 17 transplantation transplantation NN cord-005453-4057qib7 6964 18 ( ( -LRB- cord-005453-4057qib7 6964 19 MSD MSD NNP cord-005453-4057qib7 6964 20 - - HYPH cord-005453-4057qib7 6964 21 HSCT HSCT NNP cord-005453-4057qib7 6964 22 ) ) -RRB- cord-005453-4057qib7 6964 23 for for IN cord-005453-4057qib7 6964 24 PNH PNH NNP cord-005453-4057qib7 6964 25 . . . cord-005453-4057qib7 6965 1 Methods method NNS cord-005453-4057qib7 6965 2 : : : cord-005453-4057qib7 6966 1 The the DT cord-005453-4057qib7 6966 2 clinical clinical JJ cord-005453-4057qib7 6966 3 data datum NNS cord-005453-4057qib7 6966 4 of of IN cord-005453-4057qib7 6966 5 40 40 CD cord-005453-4057qib7 6966 6 PNH PNH NNP cord-005453-4057qib7 6966 7 patients patient NNS cord-005453-4057qib7 6966 8 received receive VBD cord-005453-4057qib7 6966 9 HSCT HSCT NNP cord-005453-4057qib7 6966 10 ( ( -LRB- cord-005453-4057qib7 6966 11 haplo haplo NNP cord-005453-4057qib7 6966 12 - - HYPH cord-005453-4057qib7 6966 13 HSCT HSCT NNP cord-005453-4057qib7 6966 14 = = NFP cord-005453-4057qib7 6967 1 25 25 CD cord-005453-4057qib7 6967 2 , , , cord-005453-4057qib7 6967 3 MSD MSD NNP cord-005453-4057qib7 6967 4 - - HYPH cord-005453-4057qib7 6967 5 HSCT HSCT NNP cord-005453-4057qib7 6967 6 = = SYM cord-005453-4057qib7 6967 7 15 15 CD cord-005453-4057qib7 6967 8 ) ) -RRB- cord-005453-4057qib7 6967 9 in in IN cord-005453-4057qib7 6967 10 our -PRON- PRP$ cord-005453-4057qib7 6967 11 center center NN cord-005453-4057qib7 6967 12 from from IN cord-005453-4057qib7 6967 13 July July NNP cord-005453-4057qib7 6967 14 2007 2007 CD cord-005453-4057qib7 6967 15 to to IN cord-005453-4057qib7 6967 16 May May NNP cord-005453-4057qib7 6967 17 2018 2018 CD cord-005453-4057qib7 6967 18 were be VBD cord-005453-4057qib7 6967 19 analyzed analyze VBN cord-005453-4057qib7 6967 20 retrospectively retrospectively RB cord-005453-4057qib7 6967 21 to to TO cord-005453-4057qib7 6967 22 compare compare VB cord-005453-4057qib7 6967 23 the the DT cord-005453-4057qib7 6967 24 outcomes outcome NNS cord-005453-4057qib7 6967 25 of of IN cord-005453-4057qib7 6967 26 haplo haplo NNP cord-005453-4057qib7 6967 27 - - HYPH cord-005453-4057qib7 6967 28 HSCT HSCT NNP cord-005453-4057qib7 6967 29 group group NN cord-005453-4057qib7 6967 30 with with IN cord-005453-4057qib7 6967 31 MSD MSD NNP cord-005453-4057qib7 6967 32 - - HYPH cord-005453-4057qib7 6967 33 HSCT HSCT NNP cord-005453-4057qib7 6967 34 group group NN cord-005453-4057qib7 6967 35 . . . cord-005453-4057qib7 6968 1 The the DT cord-005453-4057qib7 6968 2 clinical clinical JJ cord-005453-4057qib7 6968 3 data datum NNS cord-005453-4057qib7 6968 4 including include VBG cord-005453-4057qib7 6968 5 23 23 CD cord-005453-4057qib7 6968 6 male male JJ cord-005453-4057qib7 6968 7 patients patient NNS cord-005453-4057qib7 6968 8 and and CC cord-005453-4057qib7 6968 9 17 17 CD cord-005453-4057qib7 6968 10 female female JJ cord-005453-4057qib7 6968 11 patients patient NNS cord-005453-4057qib7 6968 12 , , , cord-005453-4057qib7 6968 13 13 13 CD cord-005453-4057qib7 6968 14 classical classical JJ cord-005453-4057qib7 6968 15 PNH PNH NNP cord-005453-4057qib7 6968 16 and and CC cord-005453-4057qib7 6968 17 27 27 CD cord-005453-4057qib7 6968 18 PNH PNH NNP cord-005453-4057qib7 6968 19 - - HYPH cord-005453-4057qib7 6968 20 AA AA NNP cord-005453-4057qib7 6968 21 syndrome syndrome NN cord-005453-4057qib7 6968 22 , , , cord-005453-4057qib7 6968 23 the the DT cord-005453-4057qib7 6968 24 median median JJ cord-005453-4057qib7 6968 25 age age NN cord-005453-4057qib7 6968 26 was be VBD cord-005453-4057qib7 6968 27 29 29 CD cord-005453-4057qib7 6968 28 years year NNS cord-005453-4057qib7 6969 1 ( ( -LRB- cord-005453-4057qib7 6969 2 range range NNP cord-005453-4057qib7 6969 3 6 6 CD cord-005453-4057qib7 6969 4 - - SYM cord-005453-4057qib7 6969 5 54 54 CD cord-005453-4057qib7 6969 6 ) ) -RRB- cord-005453-4057qib7 6969 7 . . . cord-005453-4057qib7 6970 1 All all DT cord-005453-4057qib7 6970 2 patients patient NNS cord-005453-4057qib7 6970 3 had have VBD cord-005453-4057qib7 6970 4 received receive VBN cord-005453-4057qib7 6970 5 various various JJ cord-005453-4057qib7 6970 6 treatments treatment NNS cord-005453-4057qib7 6970 7 before before IN cord-005453-4057qib7 6970 8 transplantation transplantation NN cord-005453-4057qib7 6970 9 such such JJ cord-005453-4057qib7 6970 10 as as IN cord-005453-4057qib7 6970 11 steroids steroid NNS cord-005453-4057qib7 6970 12 , , , cord-005453-4057qib7 6970 13 androgens androgen NNS cord-005453-4057qib7 6970 14 , , , cord-005453-4057qib7 6970 15 cyclosporine cyclosporine NN cord-005453-4057qib7 6970 16 ( ( -LRB- cord-005453-4057qib7 6970 17 CsA CsA NNP cord-005453-4057qib7 6970 18 ) ) -RRB- cord-005453-4057qib7 6970 19 , , , cord-005453-4057qib7 6970 20 antithymocyte antithymocyte NNP cord-005453-4057qib7 6970 21 globulin globulin NN cord-005453-4057qib7 6970 22 , , , cord-005453-4057qib7 6970 23 and and CC cord-005453-4057qib7 6970 24 growth growth NN cord-005453-4057qib7 6970 25 factors factor NNS cord-005453-4057qib7 6970 26 . . . cord-005453-4057qib7 6971 1 The the DT cord-005453-4057qib7 6971 2 median median JJ cord-005453-4057qib7 6971 3 interval interval NN cord-005453-4057qib7 6971 4 from from IN cord-005453-4057qib7 6971 5 PNH PNH NNP cord-005453-4057qib7 6971 6 diagnosis diagnosis NN cord-005453-4057qib7 6971 7 to to IN cord-005453-4057qib7 6971 8 SCT SCT NNP cord-005453-4057qib7 6971 9 was be VBD cord-005453-4057qib7 6971 10 6 6 CD cord-005453-4057qib7 6971 11 months month NNS cord-005453-4057qib7 6972 1 ( ( -LRB- cord-005453-4057qib7 6972 2 range range NNP cord-005453-4057qib7 6972 3 3 3 CD cord-005453-4057qib7 6972 4 - - SYM cord-005453-4057qib7 6972 5 240 240 CD cord-005453-4057qib7 6972 6 ) ) -RRB- cord-005453-4057qib7 6972 7 . . . cord-005453-4057qib7 6973 1 The the DT cord-005453-4057qib7 6973 2 conditioning conditioning NN cord-005453-4057qib7 6973 3 regimen regimen NN cord-005453-4057qib7 6973 4 was be VBD cord-005453-4057qib7 6973 5 modified modify VBN cord-005453-4057qib7 6973 6 BuCybased BuCybased NNP cord-005453-4057qib7 6973 7 regimen regimen NN cord-005453-4057qib7 6973 8 in in IN cord-005453-4057qib7 6973 9 haplo haplo NNP cord-005453-4057qib7 6973 10 - - HYPH cord-005453-4057qib7 6973 11 HSCT HSCT NNP cord-005453-4057qib7 6973 12 group group NN cord-005453-4057qib7 6973 13 , , , cord-005453-4057qib7 6973 14 CsA CsA NNP cord-005453-4057qib7 6973 15 , , , cord-005453-4057qib7 6973 16 mycophenolate mycophenolate NNP cord-005453-4057qib7 6973 17 mofetil mofetil NNP cord-005453-4057qib7 6973 18 ( ( -LRB- cord-005453-4057qib7 6973 19 MMF MMF NNP cord-005453-4057qib7 6973 20 ) ) -RRB- cord-005453-4057qib7 6973 21 and and CC cord-005453-4057qib7 6973 22 short short JJ cord-005453-4057qib7 6973 23 - - HYPH cord-005453-4057qib7 6973 24 term term NN cord-005453-4057qib7 6973 25 methotrexate methotrexate NNP cord-005453-4057qib7 6973 26 ( ( -LRB- cord-005453-4057qib7 6973 27 MTX MTX NNP cord-005453-4057qib7 6973 28 ) ) -RRB- cord-005453-4057qib7 6973 29 were be VBD cord-005453-4057qib7 6973 30 administered administer VBN cord-005453-4057qib7 6973 31 for for IN cord-005453-4057qib7 6973 32 graft graft NN cord-005453-4057qib7 6973 33 - - HYPH cord-005453-4057qib7 6973 34 versus versus IN cord-005453-4057qib7 6973 35 host host NN cord-005453-4057qib7 6973 36 disease disease NN cord-005453-4057qib7 6973 37 ( ( -LRB- cord-005453-4057qib7 6973 38 GVHD GVHD NNP cord-005453-4057qib7 6973 39 ) ) -RRB- cord-005453-4057qib7 6973 40 prophylaxis prophylaxis NN cord-005453-4057qib7 6973 41 . . . cord-005453-4057qib7 6974 1 Patients patient NNS cord-005453-4057qib7 6974 2 with with IN cord-005453-4057qib7 6974 3 MSD MSD NNP cord-005453-4057qib7 6974 4 - - HYPH cord-005453-4057qib7 6974 5 HSCT HSCT NNP cord-005453-4057qib7 6974 6 were be VBD cord-005453-4057qib7 6974 7 treated treat VBN cord-005453-4057qib7 6974 8 with with IN cord-005453-4057qib7 6974 9 the the DT cord-005453-4057qib7 6974 10 FluCy flucy NN cord-005453-4057qib7 6974 11 - - HYPH cord-005453-4057qib7 6974 12 based base VBN cord-005453-4057qib7 6974 13 regimen regimen NN cord-005453-4057qib7 6974 14 and and CC cord-005453-4057qib7 6974 15 CsA CsA NNP cord-005453-4057qib7 6974 16 were be VBD cord-005453-4057qib7 6974 17 administered administer VBN cord-005453-4057qib7 6974 18 for for IN cord-005453-4057qib7 6974 19 GVHD GVHD NNP cord-005453-4057qib7 6974 20 prophylaxis prophylaxis NN cord-005453-4057qib7 6974 21 . . . cord-005453-4057qib7 6975 1 Results result NNS cord-005453-4057qib7 6975 2 : : : cord-005453-4057qib7 6976 1 There there EX cord-005453-4057qib7 6976 2 were be VBD cord-005453-4057qib7 6976 3 no no DT cord-005453-4057qib7 6976 4 differences difference NNS cord-005453-4057qib7 6976 5 of of IN cord-005453-4057qib7 6976 6 gender gender NN cord-005453-4057qib7 6976 7 , , , cord-005453-4057qib7 6976 8 age age NN cord-005453-4057qib7 6976 9 , , , cord-005453-4057qib7 6976 10 patients patient NNS cord-005453-4057qib7 6976 11 of of IN cord-005453-4057qib7 6976 12 PNH PNH NNP cord-005453-4057qib7 6976 13 - - HYPH cord-005453-4057qib7 6976 14 AA AA NNP cord-005453-4057qib7 6976 15 and and CC cord-005453-4057qib7 6976 16 median median JJ cord-005453-4057qib7 6976 17 time time NN cord-005453-4057qib7 6976 18 from from IN cord-005453-4057qib7 6976 19 diagnosis diagnosis NN cord-005453-4057qib7 6976 20 to to IN cord-005453-4057qib7 6976 21 transplantation transplantation NN cord-005453-4057qib7 6976 22 between between IN cord-005453-4057qib7 6976 23 the the DT cord-005453-4057qib7 6976 24 2 2 CD cord-005453-4057qib7 6976 25 groups group NNS cord-005453-4057qib7 6976 26 ( ( -LRB- cord-005453-4057qib7 6976 27 På På NNP cord-005453-4057qib7 6976 28 0.05 0.05 CD cord-005453-4057qib7 6976 29 ) ) -RRB- cord-005453-4057qib7 6976 30 . . . cord-005453-4057qib7 6977 1 The the DT cord-005453-4057qib7 6977 2 median median JJ cord-005453-4057qib7 6977 3 values value NNS cord-005453-4057qib7 6977 4 of of IN cord-005453-4057qib7 6977 5 absolute absolute JJ cord-005453-4057qib7 6977 6 nucleated nucleated JJ cord-005453-4057qib7 6977 7 cell cell NN cord-005453-4057qib7 6977 8 counts count NNS cord-005453-4057qib7 6977 9 were be VBD cord-005453-4057qib7 6977 10 10.74 10.74 CD cord-005453-4057qib7 6977 11 ( ( -LRB- cord-005453-4057qib7 6977 12 4.80 4.80 CD cord-005453-4057qib7 6977 13 - - SYM cord-005453-4057qib7 6977 14 22.86 22.86 CD cord-005453-4057qib7 6977 15 ) ) -RRB- cord-005453-4057qib7 6978 1 ×10 ×10 NNS cord-005453-4057qib7 6978 2 8 8 CD cord-005453-4057qib7 6979 1 /kg /kg NFP cord-005453-4057qib7 6979 2 in in IN cord-005453-4057qib7 6979 3 the the DT cord-005453-4057qib7 6979 4 haplo haplo NNP cord-005453-4057qib7 6979 5 - - HYPH cord-005453-4057qib7 6979 6 HSCT HSCT NNP cord-005453-4057qib7 6979 7 group group NN cord-005453-4057qib7 6979 8 and and CC cord-005453-4057qib7 6979 9 12.19 12.19 CD cord-005453-4057qib7 6979 10 ( ( -LRB- cord-005453-4057qib7 6979 11 5.14 5.14 CD cord-005453-4057qib7 6979 12 - - SYM cord-005453-4057qib7 6979 13 17.25 17.25 CD cord-005453-4057qib7 6979 14 ) ) -RRB- cord-005453-4057qib7 6980 1 ×10 ×10 NFP cord-005453-4057qib7 6980 2 8 8 CD cord-005453-4057qib7 6980 3 /kg /kg NFP cord-005453-4057qib7 6980 4 in in IN cord-005453-4057qib7 6980 5 the the DT cord-005453-4057qib7 6980 6 MSD MSD NNP cord-005453-4057qib7 6980 7 - - HYPH cord-005453-4057qib7 6980 8 HSCT HSCT NNP cord-005453-4057qib7 6980 9 group group NN cord-005453-4057qib7 6980 10 ( ( -LRB- cord-005453-4057qib7 6980 11 P p NN cord-005453-4057qib7 6980 12 = = SYM cord-005453-4057qib7 6980 13 0.866 0.866 CD cord-005453-4057qib7 6980 14 ) ) -RRB- cord-005453-4057qib7 6980 15 . . . cord-005453-4057qib7 6981 1 The the DT cord-005453-4057qib7 6981 2 median median JJ cord-005453-4057qib7 6981 3 doses dose NNS cord-005453-4057qib7 6981 4 of of IN cord-005453-4057qib7 6981 5 CD34 CD34 NNP cord-005453-4057qib7 6981 6 + + CC cord-005453-4057qib7 6981 7 cells cell NNS cord-005453-4057qib7 6981 8 infused infuse VBN cord-005453-4057qib7 6981 9 were be VBD cord-005453-4057qib7 6981 10 3.57 3.57 CD cord-005453-4057qib7 6981 11 ( ( -LRB- cord-005453-4057qib7 6981 12 0.68 0.68 CD cord-005453-4057qib7 6981 13 - - SYM cord-005453-4057qib7 6981 14 7.80 7.80 CD cord-005453-4057qib7 6981 15 ) ) -RRB- cord-005453-4057qib7 6981 16 ×10 ×10 NFP cord-005453-4057qib7 6981 17 6 6 CD cord-005453-4057qib7 6981 18 /kg /kg NFP cord-005453-4057qib7 6981 19 and and CC cord-005453-4057qib7 6981 20 4.00 4.00 CD cord-005453-4057qib7 6981 21 ( ( -LRB- cord-005453-4057qib7 6981 22 3.02 3.02 CD cord-005453-4057qib7 6981 23 - - HYPH cord-005453-4057qib7 6981 24 8.42 8.42 CD cord-005453-4057qib7 6981 25 ) ) -RRB- cord-005453-4057qib7 6982 1 ×10 ×10 NFP cord-005453-4057qib7 6982 2 6 6 CD cord-005453-4057qib7 6983 1 /kg /kg NFP cord-005453-4057qib7 6983 2 ( ( -LRB- cord-005453-4057qib7 6983 3 P p NN cord-005453-4057qib7 6983 4 = = SYM cord-005453-4057qib7 6983 5 0.151 0.151 CD cord-005453-4057qib7 6983 6 ) ) -RRB- cord-005453-4057qib7 6983 7 , , , cord-005453-4057qib7 6983 8 respectively respectively RB cord-005453-4057qib7 6983 9 . . . cord-005453-4057qib7 6984 1 All all DT cord-005453-4057qib7 6984 2 patients patient NNS cord-005453-4057qib7 6984 3 attained attain VBD cord-005453-4057qib7 6984 4 complete complete JJ cord-005453-4057qib7 6984 5 engraftment engraftment NN cord-005453-4057qib7 6984 6 , , , cord-005453-4057qib7 6984 7 no no DT cord-005453-4057qib7 6984 8 patient patient NN cord-005453-4057qib7 6984 9 occurred occur VBD cord-005453-4057qib7 6984 10 graft graft NN cord-005453-4057qib7 6984 11 failure failure NN cord-005453-4057qib7 6984 12 . . . cord-005453-4057qib7 6985 1 The the DT cord-005453-4057qib7 6985 2 median median JJ cord-005453-4057qib7 6985 3 time time NN cord-005453-4057qib7 6985 4 for for IN cord-005453-4057qib7 6985 5 myeloid myeloid NN cord-005453-4057qib7 6985 6 engraftment engraftment NN cord-005453-4057qib7 6985 7 were be VBD cord-005453-4057qib7 6985 8 12 12 CD cord-005453-4057qib7 6986 1 ( ( -LRB- cord-005453-4057qib7 6986 2 range range NN cord-005453-4057qib7 6986 3 , , , cord-005453-4057qib7 6986 4 9 9 CD cord-005453-4057qib7 6986 5 - - SYM cord-005453-4057qib7 6986 6 26 26 CD cord-005453-4057qib7 6986 7 ) ) -RRB- cord-005453-4057qib7 6986 8 days day NNS cord-005453-4057qib7 6986 9 in in IN cord-005453-4057qib7 6986 10 the the DT cord-005453-4057qib7 6986 11 haplo haplo NNP cord-005453-4057qib7 6986 12 - - HYPH cord-005453-4057qib7 6986 13 HSCT HSCT NNP cord-005453-4057qib7 6986 14 group group NN cord-005453-4057qib7 6986 15 and and CC cord-005453-4057qib7 6986 16 11 11 CD cord-005453-4057qib7 6986 17 ( ( -LRB- cord-005453-4057qib7 6986 18 range range NN cord-005453-4057qib7 6986 19 , , , cord-005453-4057qib7 6986 20 7 7 CD cord-005453-4057qib7 6986 21 - - SYM cord-005453-4057qib7 6986 22 15 15 CD cord-005453-4057qib7 6986 23 ) ) -RRB- cord-005453-4057qib7 6986 24 days day NNS cord-005453-4057qib7 6986 25 in in IN cord-005453-4057qib7 6986 26 the the DT cord-005453-4057qib7 6986 27 MSD MSD NNP cord-005453-4057qib7 6986 28 - - HYPH cord-005453-4057qib7 6986 29 HSCT HSCT NNP cord-005453-4057qib7 6986 30 group group NN cord-005453-4057qib7 6986 31 ( ( -LRB- cord-005453-4057qib7 6986 32 P p NN cord-005453-4057qib7 6986 33 = = SYM cord-005453-4057qib7 6986 34 0.065 0.065 CD cord-005453-4057qib7 6986 35 ) ) -RRB- cord-005453-4057qib7 6986 36 . . . cord-005453-4057qib7 6987 1 The the DT cord-005453-4057qib7 6987 2 median median JJ cord-005453-4057qib7 6987 3 time time NN cord-005453-4057qib7 6987 4 for for IN cord-005453-4057qib7 6987 5 platelet platelet NN cord-005453-4057qib7 6987 6 engraftment engraftment NN cord-005453-4057qib7 6987 7 were be VBD cord-005453-4057qib7 6987 8 19 19 CD cord-005453-4057qib7 6988 1 ( ( -LRB- cord-005453-4057qib7 6988 2 range range NN cord-005453-4057qib7 6988 3 , , , cord-005453-4057qib7 6988 4 11 11 CD cord-005453-4057qib7 6988 5 - - SYM cord-005453-4057qib7 6988 6 75 75 CD cord-005453-4057qib7 6988 7 ) ) -RRB- cord-005453-4057qib7 6988 8 days day NNS cord-005453-4057qib7 6988 9 and and CC cord-005453-4057qib7 6988 10 13 13 CD cord-005453-4057qib7 6989 1 ( ( -LRB- cord-005453-4057qib7 6989 2 range range NN cord-005453-4057qib7 6989 3 , , , cord-005453-4057qib7 6989 4 11 11 CD cord-005453-4057qib7 6989 5 - - SYM cord-005453-4057qib7 6989 6 25 25 CD cord-005453-4057qib7 6989 7 ) ) -RRB- cord-005453-4057qib7 6989 8 days day NNS cord-005453-4057qib7 6989 9 ( ( -LRB- cord-005453-4057qib7 6989 10 P p NN cord-005453-4057qib7 6989 11 = = SYM cord-005453-4057qib7 6989 12 0.027 0.027 CD cord-005453-4057qib7 6989 13 ) ) -RRB- cord-005453-4057qib7 6989 14 , , , cord-005453-4057qib7 6989 15 respectively respectively RB cord-005453-4057qib7 6989 16 . . . cord-005453-4057qib7 6990 1 With with IN cord-005453-4057qib7 6990 2 a a DT cord-005453-4057qib7 6990 3 median median JJ cord-005453-4057qib7 6990 4 followup followup NN cord-005453-4057qib7 6990 5 of of IN cord-005453-4057qib7 6990 6 26 26 CD cord-005453-4057qib7 6990 7 ( ( -LRB- cord-005453-4057qib7 6990 8 4 4 CD cord-005453-4057qib7 6990 9 - - SYM cord-005453-4057qib7 6990 10 65 65 CD cord-005453-4057qib7 6990 11 ) ) -RRB- cord-005453-4057qib7 6990 12 months month NNS cord-005453-4057qib7 6990 13 in in IN cord-005453-4057qib7 6990 14 the the DT cord-005453-4057qib7 6990 15 haplo haplo NNP cord-005453-4057qib7 6990 16 - - HYPH cord-005453-4057qib7 6990 17 HSCT HSCT NNP cord-005453-4057qib7 6990 18 group group NN cord-005453-4057qib7 6990 19 and and CC cord-005453-4057qib7 6990 20 36 36 CD cord-005453-4057qib7 6990 21 ( ( -LRB- cord-005453-4057qib7 6990 22 4 4 CD cord-005453-4057qib7 6990 23 - - SYM cord-005453-4057qib7 6990 24 132 132 CD cord-005453-4057qib7 6990 25 ) ) -RRB- cord-005453-4057qib7 6990 26 months month NNS cord-005453-4057qib7 6990 27 in in IN cord-005453-4057qib7 6990 28 the the DT cord-005453-4057qib7 6990 29 MSD MSD NNP cord-005453-4057qib7 6990 30 - - HYPH cord-005453-4057qib7 6990 31 HSCT HSCT NNP cord-005453-4057qib7 6990 32 group group NN cord-005453-4057qib7 6990 33 ( ( -LRB- cord-005453-4057qib7 6990 34 P p NN cord-005453-4057qib7 6990 35 = = SYM cord-005453-4057qib7 6990 36 0.294 0.294 CD cord-005453-4057qib7 6990 37 ) ) -RRB- cord-005453-4057qib7 6990 38 . . . cord-005453-4057qib7 6991 1 In in IN cord-005453-4057qib7 6991 2 haplo haplo NNP cord-005453-4057qib7 6991 3 - - HYPH cord-005453-4057qib7 6991 4 HSCT HSCT NNP cord-005453-4057qib7 6991 5 and and CC cord-005453-4057qib7 6991 6 MSD MSD NNP cord-005453-4057qib7 6991 7 - - HYPH cord-005453-4057qib7 6991 8 HSCT HSCT NNP cord-005453-4057qib7 6991 9 groups group NNS cord-005453-4057qib7 6991 10 the the DT cord-005453-4057qib7 6991 11 incidences incidence NNS cord-005453-4057qib7 6991 12 of of IN cord-005453-4057qib7 6991 13 grade grade NN cord-005453-4057qib7 6991 14 I I NNP cord-005453-4057qib7 6991 15 - - HYPH cord-005453-4057qib7 6991 16 IV IV NNP cord-005453-4057qib7 6991 17 acute acute JJ cord-005453-4057qib7 6991 18 graft graft NN cord-005453-4057qib7 6991 19 - - HYPH cord-005453-4057qib7 6991 20 versus versus IN cord-005453-4057qib7 6991 21 - - HYPH cord-005453-4057qib7 6991 22 host host NN cord-005453-4057qib7 6991 23 disease disease NN cord-005453-4057qib7 6991 24 ( ( -LRB- cord-005453-4057qib7 6991 25 aGVHD aGVHD NNP cord-005453-4057qib7 6991 26 ) ) -RRB- cord-005453-4057qib7 6991 27 were be VBD cord-005453-4057qib7 6991 28 32.00 32.00 CD cord-005453-4057qib7 6991 29 % % NN cord-005453-4057qib7 6991 30 and and CC cord-005453-4057qib7 6991 31 20.00 20.00 CD cord-005453-4057qib7 6991 32 % % NN cord-005453-4057qib7 6991 33 ( ( -LRB- cord-005453-4057qib7 6991 34 P p NN cord-005453-4057qib7 6991 35 = = SYM cord-005453-4057qib7 6991 36 0.343 0.343 CD cord-005453-4057qib7 6991 37 ) ) -RRB- cord-005453-4057qib7 6991 38 , , , cord-005453-4057qib7 6991 39 grade grade NN cord-005453-4057qib7 6991 40 II II NNP cord-005453-4057qib7 6991 41 - - HYPH cord-005453-4057qib7 6991 42 IV IV NNP cord-005453-4057qib7 6991 43 aGVHD aGVHD NNP cord-005453-4057qib7 6991 44 were be VBD cord-005453-4057qib7 6991 45 16.00%、13.33 16.00%、13.33 CD cord-005453-4057qib7 6991 46 % % NN cord-005453-4057qib7 6991 47 ( ( -LRB- cord-005453-4057qib7 6991 48 P p NN cord-005453-4057qib7 6991 49 = = SYM cord-005453-4057qib7 6991 50 0.759 0.759 CD cord-005453-4057qib7 6991 51 ) ) -RRB- cord-005453-4057qib7 6991 52 . . . cord-005453-4057qib7 6992 1 chronic chronic JJ cord-005453-4057qib7 6992 2 GVHD GVHD NNP cord-005453-4057qib7 6992 3 were be VBD cord-005453-4057qib7 6992 4 30.69 30.69 CD cord-005453-4057qib7 6992 5 % % NN cord-005453-4057qib7 6992 6 and and CC cord-005453-4057qib7 6992 7 24.62 24.62 CD cord-005453-4057qib7 6992 8 % % NN cord-005453-4057qib7 6992 9 ( ( -LRB- cord-005453-4057qib7 6992 10 P p NN cord-005453-4057qib7 6992 11 = = SYM cord-005453-4057qib7 6992 12 0.418 0.418 CD cord-005453-4057qib7 6992 13 ) ) -RRB- cord-005453-4057qib7 6992 14 , , , cord-005453-4057qib7 6992 15 moderate moderate JJ cord-005453-4057qib7 6992 16 - - HYPH cord-005453-4057qib7 6992 17 severe severe JJ cord-005453-4057qib7 6992 18 chronic chronic JJ cord-005453-4057qib7 6992 19 GVHD GVHD NNP cord-005453-4057qib7 6992 20 were be VBD cord-005453-4057qib7 6992 21 12.73 12.73 CD cord-005453-4057qib7 6992 22 % % NN cord-005453-4057qib7 6992 23 and and CC cord-005453-4057qib7 6992 24 7.14 7.14 CD cord-005453-4057qib7 6992 25 % % NN cord-005453-4057qib7 6992 26 ( ( -LRB- cord-005453-4057qib7 6992 27 P p NN cord-005453-4057qib7 6992 28 = = SYM cord-005453-4057qib7 6992 29 0.522 0.522 CD cord-005453-4057qib7 6992 30 ) ) -RRB- cord-005453-4057qib7 6992 31 . . . cord-005453-4057qib7 6993 1 In in IN cord-005453-4057qib7 6993 2 haplo haplo NNP cord-005453-4057qib7 6993 3 - - HYPH cord-005453-4057qib7 6993 4 HSCT HSCT NNP cord-005453-4057qib7 6993 5 and and CC cord-005453-4057qib7 6993 6 MSD MSD NNP cord-005453-4057qib7 6993 7 groups group NNS cord-005453-4057qib7 6993 8 the the DT cord-005453-4057qib7 6993 9 incidences incidence NNS cord-005453-4057qib7 6993 10 of of IN cord-005453-4057qib7 6993 11 infection infection NN cord-005453-4057qib7 6993 12 were be VBD cord-005453-4057qib7 6993 13 32.00 32.00 CD cord-005453-4057qib7 6993 14 % % NN cord-005453-4057qib7 6993 15 ( ( -LRB- cord-005453-4057qib7 6993 16 8/25 8/25 CD cord-005453-4057qib7 6993 17 ) ) -RRB- cord-005453-4057qib7 6993 18 and and CC cord-005453-4057qib7 6993 19 26.67 26.67 CD cord-005453-4057qib7 6993 20 % % NN cord-005453-4057qib7 6993 21 ( ( -LRB- cord-005453-4057qib7 6993 22 4/15 4/15 CD cord-005453-4057qib7 6993 23 ) ) -RRB- cord-005453-4057qib7 6993 24 ( ( -LRB- cord-005453-4057qib7 6993 25 P p NN cord-005453-4057qib7 6993 26 = = SYM cord-005453-4057qib7 6993 27 1.000 1.000 CD cord-005453-4057qib7 6993 28 ) ) -RRB- cord-005453-4057qib7 6993 29 . . . cord-005453-4057qib7 6994 1 No no DT cord-005453-4057qib7 6994 2 patient patient NN cord-005453-4057qib7 6994 3 occurred occur VBD cord-005453-4057qib7 6994 4 early early JJ cord-005453-4057qib7 6994 5 death death NN cord-005453-4057qib7 6994 6 and and CC cord-005453-4057qib7 6994 7 relapse relapse NN cord-005453-4057qib7 6994 8 . . . cord-005453-4057qib7 6995 1 3-year 3-year CD cord-005453-4057qib7 6995 2 estimated estimate VBN cord-005453-4057qib7 6995 3 overall overall JJ cord-005453-4057qib7 6995 4 survival survival NN cord-005453-4057qib7 6995 5 ( ( -LRB- cord-005453-4057qib7 6995 6 OS OS NNP cord-005453-4057qib7 6995 7 ) ) -RRB- cord-005453-4057qib7 6995 8 of of IN cord-005453-4057qib7 6995 9 haplo haplo NNP cord-005453-4057qib7 6995 10 - - HYPH cord-005453-4057qib7 6995 11 HSCT HSCT NNP cord-005453-4057qib7 6995 12 and and CC cord-005453-4057qib7 6995 13 MSD MSD NNP cord-005453-4057qib7 6995 14 - - HYPH cord-005453-4057qib7 6995 15 HSCT HSCT NNP cord-005453-4057qib7 6995 16 groups group NNS cord-005453-4057qib7 6995 17 were be VBD cord-005453-4057qib7 6995 18 86.5 86.5 CD cord-005453-4057qib7 6995 19 % % NN cord-005453-4057qib7 6995 20 ± ± NNP cord-005453-4057qib7 6995 21 7.3 7.3 CD cord-005453-4057qib7 6995 22 % % NN cord-005453-4057qib7 6995 23 and and CC cord-005453-4057qib7 6995 24 93.3 93.3 CD cord-005453-4057qib7 6995 25 % % NN cord-005453-4057qib7 6995 26 ± ± NNP cord-005453-4057qib7 6995 27 6.4 6.4 CD cord-005453-4057qib7 6995 28 % % NN cord-005453-4057qib7 6995 29 ( ( -LRB- cord-005453-4057qib7 6995 30 P p NN cord-005453-4057qib7 6995 31 = = SYM cord-005453-4057qib7 6995 32 0.520 0.520 CD cord-005453-4057qib7 6995 33 ) ) -RRB- cord-005453-4057qib7 6995 34 , , , cord-005453-4057qib7 6995 35 GVHD GVHD NNP cord-005453-4057qib7 6995 36 - - HYPH cord-005453-4057qib7 6995 37 free free JJ cord-005453-4057qib7 6995 38 and and CC cord-005453-4057qib7 6995 39 failure failure NN cord-005453-4057qib7 6995 40 - - HYPH cord-005453-4057qib7 6995 41 free free JJ cord-005453-4057qib7 6995 42 survival survival NN cord-005453-4057qib7 6995 43 ( ( -LRB- cord-005453-4057qib7 6995 44 GFFS GFFS NNP cord-005453-4057qib7 6995 45 ) ) -RRB- cord-005453-4057qib7 6995 46 were be VBD cord-005453-4057qib7 6995 47 78.3 78.3 CD cord-005453-4057qib7 6995 48 % % NN cord-005453-4057qib7 6995 49 ± ± NNP cord-005453-4057qib7 6995 50 8.6 8.6 CD cord-005453-4057qib7 6995 51 % % NN cord-005453-4057qib7 6995 52 and and CC cord-005453-4057qib7 6995 53 92.9 92.9 CD cord-005453-4057qib7 6995 54 % % NN cord-005453-4057qib7 6995 55 ± ± NNP cord-005453-4057qib7 6995 56 6.9 6.9 CD cord-005453-4057qib7 6995 57 % % NN cord-005453-4057qib7 6995 58 ( ( -LRB- cord-005453-4057qib7 6995 59 P p NN cord-005453-4057qib7 6995 60 = = SYM cord-005453-4057qib7 6995 61 0.250 0.250 CD cord-005453-4057qib7 6995 62 ) ) -RRB- cord-005453-4057qib7 6995 63 . . . cord-005453-4057qib7 6996 1 Conclusions conclusion NNS cord-005453-4057qib7 6996 2 : : : cord-005453-4057qib7 6997 1 The the DT cord-005453-4057qib7 6997 2 preliminary preliminary JJ cord-005453-4057qib7 6997 3 results result NNS cord-005453-4057qib7 6997 4 indicated indicate VBD cord-005453-4057qib7 6997 5 that that IN cord-005453-4057qib7 6997 6 haplo haplo NNP cord-005453-4057qib7 6997 7 - - HYPH cord-005453-4057qib7 6997 8 HSCT HSCT NNP cord-005453-4057qib7 6997 9 is be VBZ cord-005453-4057qib7 6997 10 a a DT cord-005453-4057qib7 6997 11 feasible feasible JJ cord-005453-4057qib7 6997 12 choice choice NN cord-005453-4057qib7 6997 13 for for IN cord-005453-4057qib7 6997 14 PNH PNH NNP cord-005453-4057qib7 6997 15 with with IN cord-005453-4057qib7 6997 16 favorable favorable JJ cord-005453-4057qib7 6997 17 outcomes outcome NNS cord-005453-4057qib7 6997 18 , , , cord-005453-4057qib7 6997 19 haplo haplo NN cord-005453-4057qib7 6997 20 - - HYPH cord-005453-4057qib7 6997 21 HSCT HSCT NNP cord-005453-4057qib7 6997 22 and and CC cord-005453-4057qib7 6997 23 MSD MSD NNP cord-005453-4057qib7 6997 24 - - HYPH cord-005453-4057qib7 6997 25 HSCT HSCT NNP cord-005453-4057qib7 6997 26 had have VBD cord-005453-4057qib7 6997 27 similar similar JJ cord-005453-4057qib7 6997 28 therapeutic therapeutic JJ cord-005453-4057qib7 6997 29 efficacy efficacy NN cord-005453-4057qib7 6997 30 . . . cord-005453-4057qib7 6998 1 Disclosure disclosure NN cord-005453-4057qib7 6998 2 : : : cord-005453-4057qib7 6998 3 no no DT cord-005453-4057qib7 6998 4 disclosure disclosure NN cord-005453-4057qib7 6998 5 P320 p320 NN cord-005453-4057qib7 6998 6 Pres Pres NNP cord-005453-4057qib7 6998 7 in in IN cord-005453-4057qib7 6998 8 BMT BMT NNP cord-005453-4057qib7 6998 9 for for IN cord-005453-4057qib7 6998 10 thalassemia thalassemia NN cord-005453-4057qib7 6998 11 major major NN cord-005453-4057qib7 6998 12 in in IN cord-005453-4057qib7 6998 13 India India NNP cord-005453-4057qib7 6998 14 : : : cord-005453-4057qib7 6999 1 Lower low JJR cord-005453-4057qib7 6999 2 incidence incidence NN cord-005453-4057qib7 6999 3 and and CC cord-005453-4057qib7 6999 4 limited limited JJ cord-005453-4057qib7 6999 5 impact impact NN cord-005453-4057qib7 7000 1 Background background NN cord-005453-4057qib7 7000 2 : : : cord-005453-4057qib7 7000 3 Posterior posterior JJ cord-005453-4057qib7 7000 4 reversible reversible JJ cord-005453-4057qib7 7000 5 encephalopathy encephalopathy NN cord-005453-4057qib7 7000 6 syndrome syndrome NN cord-005453-4057qib7 7000 7 ( ( -LRB- cord-005453-4057qib7 7000 8 PRES PRES NNP cord-005453-4057qib7 7000 9 ) ) -RRB- cord-005453-4057qib7 7000 10 is be VBZ cord-005453-4057qib7 7000 11 a a DT cord-005453-4057qib7 7000 12 relatively relatively RB cord-005453-4057qib7 7000 13 common common JJ cord-005453-4057qib7 7000 14 complication complication NN cord-005453-4057qib7 7000 15 seen see VBN cord-005453-4057qib7 7000 16 after after IN cord-005453-4057qib7 7000 17 blood blood NN cord-005453-4057qib7 7000 18 or or CC cord-005453-4057qib7 7000 19 marrow marrow NN cord-005453-4057qib7 7000 20 transplantation transplantation NN cord-005453-4057qib7 7000 21 ( ( -LRB- cord-005453-4057qib7 7000 22 BMT BMT NNP cord-005453-4057qib7 7000 23 ) ) -RRB- cord-005453-4057qib7 7000 24 for for IN cord-005453-4057qib7 7000 25 hemoglobinopathies hemoglobinopathy NNS cord-005453-4057qib7 7000 26 with with IN cord-005453-4057qib7 7000 27 a a DT cord-005453-4057qib7 7000 28 reported report VBN cord-005453-4057qib7 7000 29 frequency frequency NN cord-005453-4057qib7 7000 30 of of IN cord-005453-4057qib7 7000 31 10 10 CD cord-005453-4057qib7 7000 32 - - SYM cord-005453-4057qib7 7000 33 19 19 CD cord-005453-4057qib7 7000 34 % % NN cord-005453-4057qib7 7000 35 . . . cord-005453-4057qib7 7001 1 PRES PRES NNP cord-005453-4057qib7 7001 2 has have VBZ cord-005453-4057qib7 7001 3 also also RB cord-005453-4057qib7 7001 4 been be VBN cord-005453-4057qib7 7001 5 associated associate VBN cord-005453-4057qib7 7001 6 with with IN cord-005453-4057qib7 7001 7 poorer poor JJR cord-005453-4057qib7 7001 8 survival survival NN cord-005453-4057qib7 7001 9 rates rate NNS cord-005453-4057qib7 7001 10 . . . cord-005453-4057qib7 7002 1 Severe severe JJ cord-005453-4057qib7 7002 2 hemoglobinopathies hemoglobinopathy NNS cord-005453-4057qib7 7002 3 are be VBP cord-005453-4057qib7 7002 4 one one CD cord-005453-4057qib7 7002 5 of of IN cord-005453-4057qib7 7002 6 the the DT cord-005453-4057qib7 7002 7 most most RBS cord-005453-4057qib7 7002 8 frequent frequent JJ cord-005453-4057qib7 7002 9 indications indication NNS cord-005453-4057qib7 7002 10 for for IN cord-005453-4057qib7 7002 11 BMT BMT NNP cord-005453-4057qib7 7002 12 in in IN cord-005453-4057qib7 7002 13 the the DT cord-005453-4057qib7 7002 14 developing develop VBG cord-005453-4057qib7 7002 15 world world NN cord-005453-4057qib7 7002 16 , , , cord-005453-4057qib7 7002 17 particularly particularly RB cord-005453-4057qib7 7002 18 in in IN cord-005453-4057qib7 7002 19 India India NNP cord-005453-4057qib7 7002 20 . . . cord-005453-4057qib7 7003 1 Given give VBN cord-005453-4057qib7 7003 2 the the DT cord-005453-4057qib7 7003 3 risk risk NN cord-005453-4057qib7 7003 4 of of IN cord-005453-4057qib7 7003 5 rejection rejection NN cord-005453-4057qib7 7003 6 in in IN cord-005453-4057qib7 7003 7 multiply multiply NN cord-005453-4057qib7 7003 8 transfused transfuse VBN cord-005453-4057qib7 7003 9 patients patient NNS cord-005453-4057qib7 7003 10 and and CC cord-005453-4057qib7 7003 11 the the DT cord-005453-4057qib7 7003 12 need need NN cord-005453-4057qib7 7003 13 to to TO cord-005453-4057qib7 7003 14 minimize minimize VB cord-005453-4057qib7 7003 15 GVHD GVHD NNP cord-005453-4057qib7 7003 16 risk risk NN cord-005453-4057qib7 7003 17 , , , cord-005453-4057qib7 7003 18 immunosuppression immunosuppression NN cord-005453-4057qib7 7003 19 post post NN cord-005453-4057qib7 7003 20 - - NN cord-005453-4057qib7 7003 21 BMT BMT NNP cord-005453-4057qib7 7003 22 for for IN cord-005453-4057qib7 7003 23 these these DT cord-005453-4057qib7 7003 24 non non JJ cord-005453-4057qib7 7003 25 - - JJ cord-005453-4057qib7 7003 26 malignant malignant JJ cord-005453-4057qib7 7003 27 conditions condition NNS cord-005453-4057qib7 7003 28 can can MD cord-005453-4057qib7 7003 29 be be VB cord-005453-4057qib7 7003 30 particularly particularly RB cord-005453-4057qib7 7003 31 intense intense JJ cord-005453-4057qib7 7003 32 and and CC cord-005453-4057qib7 7003 33 prolonged prolonged JJ cord-005453-4057qib7 7003 34 . . . cord-005453-4057qib7 7004 1 We -PRON- PRP cord-005453-4057qib7 7004 2 sought seek VBD cord-005453-4057qib7 7004 3 to to TO cord-005453-4057qib7 7004 4 measure measure VB cord-005453-4057qib7 7004 5 the the DT cord-005453-4057qib7 7004 6 incidence incidence NN cord-005453-4057qib7 7004 7 and and CC cord-005453-4057qib7 7004 8 impact impact NN cord-005453-4057qib7 7004 9 of of IN cord-005453-4057qib7 7004 10 PRES PRES NNP cord-005453-4057qib7 7004 11 in in IN cord-005453-4057qib7 7004 12 developing develop VBG cord-005453-4057qib7 7004 13 countries country NNS cord-005453-4057qib7 7004 14 . . . cord-005453-4057qib7 7005 1 Methods method NNS cord-005453-4057qib7 7005 2 : : : cord-005453-4057qib7 7005 3 We -PRON- PRP cord-005453-4057qib7 7005 4 analysed analyse VBD cord-005453-4057qib7 7005 5 194 194 CD cord-005453-4057qib7 7005 6 successive successive JJ cord-005453-4057qib7 7005 7 transplants transplant NNS cord-005453-4057qib7 7005 8 for for IN cord-005453-4057qib7 7005 9 thalassemia thalassemia NN cord-005453-4057qib7 7005 10 using use VBG cord-005453-4057qib7 7005 11 Protocol Protocol NNP cord-005453-4057qib7 7005 12 1 1 CD cord-005453-4057qib7 7005 13 ( ( -LRB- cord-005453-4057qib7 7005 14 ATG ATG NNP cord-005453-4057qib7 7005 15 - - HYPH cord-005453-4057qib7 7005 16 BuCy+CSA BuCy+CSA NNP cord-005453-4057qib7 7005 17 / / SYM cord-005453-4057qib7 7005 18 MMF mmf NN cord-005453-4057qib7 7005 19 or or CC cord-005453-4057qib7 7005 20 CSA CSA NNP cord-005453-4057qib7 7005 21 / / SYM cord-005453-4057qib7 7005 22 MTX MTX NNP cord-005453-4057qib7 7005 23 ) ) -RRB- cord-005453-4057qib7 7005 24 maintaining maintain VBG cord-005453-4057qib7 7005 25 cyclosporine cyclosporine NN cord-005453-4057qib7 7005 26 A a NN cord-005453-4057qib7 7005 27 ( ( -LRB- cord-005453-4057qib7 7005 28 CSA CSA NNP cord-005453-4057qib7 7005 29 ) ) -RRB- cord-005453-4057qib7 7005 30 blood blood NN cord-005453-4057qib7 7005 31 levels level NNS cord-005453-4057qib7 7005 32 100 100 CD cord-005453-4057qib7 7005 33 - - SYM cord-005453-4057qib7 7005 34 150 150 CD cord-005453-4057qib7 7005 35 ng ng NN cord-005453-4057qib7 7005 36 / / SYM cord-005453-4057qib7 7005 37 mL ml NN cord-005453-4057qib7 7005 38 for for IN cord-005453-4057qib7 7005 39 74 74 CD cord-005453-4057qib7 7005 40 patients patient NNS cord-005453-4057qib7 7005 41 and and CC cord-005453-4057qib7 7005 42 Protocol Protocol NNP cord-005453-4057qib7 7005 43 2 2 CD cord-005453-4057qib7 7005 44 ( ( -LRB- cord-005453-4057qib7 7005 45 FLU FLU NNP cord-005453-4057qib7 7005 46 - - HYPH cord-005453-4057qib7 7005 47 ATG ATG NNP cord-005453-4057qib7 7005 48 - - HYPH cord-005453-4057qib7 7005 49 BuCy+CSA BuCy+CSA NNP cord-005453-4057qib7 7005 50 / / SYM cord-005453-4057qib7 7005 51 MTX MTX NNP cord-005453-4057qib7 7005 52 ) ) -RRB- cord-005453-4057qib7 7005 53 maintaining maintain VBG cord-005453-4057qib7 7005 54 higher high JJR cord-005453-4057qib7 7005 55 CSA CSA NNP cord-005453-4057qib7 7005 56 levels level NNS cord-005453-4057qib7 7005 57 post post NN cord-005453-4057qib7 7005 58 , , , cord-005453-4057qib7 7005 59 i.e. i.e. FW cord-005453-4057qib7 7005 60 150 150 CD cord-005453-4057qib7 7005 61 - - SYM cord-005453-4057qib7 7005 62 250 250 CD cord-005453-4057qib7 7005 63 ng ng NN cord-005453-4057qib7 7005 64 / / SYM cord-005453-4057qib7 7005 65 mL ml NN cord-005453-4057qib7 7005 66 for for IN cord-005453-4057qib7 7005 67 120 120 CD cord-005453-4057qib7 7005 68 patients patient NNS cord-005453-4057qib7 7005 69 from from IN cord-005453-4057qib7 7005 70 fully fully RB cord-005453-4057qib7 7005 71 matched match VBN cord-005453-4057qib7 7005 72 donors donor NNS cord-005453-4057qib7 7005 73 with with IN cord-005453-4057qib7 7005 74 G G NNP cord-005453-4057qib7 7005 75 - - HYPH cord-005453-4057qib7 7005 76 CSF csf NN cord-005453-4057qib7 7005 77 - - HYPH cord-005453-4057qib7 7005 78 primed prime VBN cord-005453-4057qib7 7005 79 bone bone NN cord-005453-4057qib7 7005 80 marrow marrow NN cord-005453-4057qib7 7005 81 . . . cord-005453-4057qib7 7006 1 For for IN cord-005453-4057qib7 7006 2 3 3 CD cord-005453-4057qib7 7006 3 patients patient NNS cord-005453-4057qib7 7006 4 this this DT cord-005453-4057qib7 7006 5 was be VBD cord-005453-4057qib7 7006 6 the the DT cord-005453-4057qib7 7006 7 second second JJ cord-005453-4057qib7 7006 8 transplant transplant NN cord-005453-4057qib7 7006 9 from from IN cord-005453-4057qib7 7006 10 a a DT cord-005453-4057qib7 7006 11 different different JJ cord-005453-4057qib7 7006 12 matched match VBN cord-005453-4057qib7 7006 13 related related JJ cord-005453-4057qib7 7006 14 donor donor NN cord-005453-4057qib7 7006 15 . . . cord-005453-4057qib7 7007 1 PRES PRES NNP cord-005453-4057qib7 7007 2 was be VBD cord-005453-4057qib7 7007 3 confirmed confirm VBN cord-005453-4057qib7 7007 4 with with IN cord-005453-4057qib7 7007 5 brain brain NN cord-005453-4057qib7 7007 6 CT CT NNP cord-005453-4057qib7 7007 7 / / SYM cord-005453-4057qib7 7007 8 MRI MRI NNP cord-005453-4057qib7 7007 9 for for IN cord-005453-4057qib7 7007 10 all all DT cord-005453-4057qib7 7007 11 patients patient NNS cord-005453-4057qib7 7007 12 . . . cord-005453-4057qib7 7008 1 Results result NNS cord-005453-4057qib7 7008 2 : : : cord-005453-4057qib7 7009 1 All all DT cord-005453-4057qib7 7009 2 recipients recipient NNS cord-005453-4057qib7 7009 3 who who WP cord-005453-4057qib7 7009 4 had have VBD cord-005453-4057qib7 7009 5 PRES PRES NNP cord-005453-4057qib7 7009 6 had have VBD cord-005453-4057qib7 7009 7 sibling sibling NN cord-005453-4057qib7 7009 8 donors donor NNS cord-005453-4057qib7 7009 9 , , , cord-005453-4057qib7 7009 10 5 5 CD cord-005453-4057qib7 7009 11 males male NNS cord-005453-4057qib7 7009 12 and and CC cord-005453-4057qib7 7009 13 2 2 CD cord-005453-4057qib7 7009 14 females female NNS cord-005453-4057qib7 7009 15 . . . cord-005453-4057qib7 7010 1 Age age NN cord-005453-4057qib7 7010 2 median median NN cord-005453-4057qib7 7010 3 7.4 7.4 CD cord-005453-4057qib7 7010 4 ( ( -LRB- cord-005453-4057qib7 7010 5 IQR IQR NNP cord-005453-4057qib7 7010 6 5.6 5.6 CD cord-005453-4057qib7 7010 7 - - SYM cord-005453-4057qib7 7010 8 8 8 CD cord-005453-4057qib7 7010 9 years year NNS cord-005453-4057qib7 7010 10 ) ) -RRB- cord-005453-4057qib7 7010 11 . . . cord-005453-4057qib7 7011 1 The the DT cord-005453-4057qib7 7011 2 frequency frequency NN cord-005453-4057qib7 7011 3 of of IN cord-005453-4057qib7 7011 4 PRES PRES NNP cord-005453-4057qib7 7011 5 was be VBD cord-005453-4057qib7 7011 6 3.6 3.6 CD cord-005453-4057qib7 7011 7 % % NN cord-005453-4057qib7 7011 8 ; ; : cord-005453-4057qib7 7011 9 disease disease NNP cord-005453-4057qib7 7011 10 free free JJ cord-005453-4057qib7 7011 11 survival survival NN cord-005453-4057qib7 7011 12 for for IN cord-005453-4057qib7 7011 13 patients patient NNS cord-005453-4057qib7 7011 14 who who WP cord-005453-4057qib7 7011 15 had have VBD cord-005453-4057qib7 7011 16 PRES PRES NNP cord-005453-4057qib7 7011 17 was be VBD cord-005453-4057qib7 7011 18 100 100 CD cord-005453-4057qib7 7011 19 % % NN cord-005453-4057qib7 7011 20 . . . cord-005453-4057qib7 7012 1 PRES PRES NNP cord-005453-4057qib7 7012 2 resolved resolve VBD cord-005453-4057qib7 7012 3 completely completely RB cord-005453-4057qib7 7012 4 in in RB cord-005453-4057qib7 7012 5 all all RB cord-005453-4057qib7 7012 6 . . . cord-005453-4057qib7 7013 1 CSA CSA NNP cord-005453-4057qib7 7013 2 was be VBD cord-005453-4057qib7 7013 3 switched switch VBN cord-005453-4057qib7 7013 4 to to IN cord-005453-4057qib7 7013 5 MMF MMF NNP cord-005453-4057qib7 7013 6 in in IN cord-005453-4057qib7 7013 7 5 5 CD cord-005453-4057qib7 7013 8 patients patient NNS cord-005453-4057qib7 7013 9 who who WP cord-005453-4057qib7 7013 10 had have VBD cord-005453-4057qib7 7013 11 received receive VBN cord-005453-4057qib7 7013 12 MTX MTX NNP cord-005453-4057qib7 7013 13 and and CC cord-005453-4057qib7 7013 14 were be VBD cord-005453-4057qib7 7013 15 on on IN cord-005453-4057qib7 7013 16 CSA CSA NNP cord-005453-4057qib7 7013 17 only only RB cord-005453-4057qib7 7013 18 at at IN cord-005453-4057qib7 7013 19 the the DT cord-005453-4057qib7 7013 20 time time NN cord-005453-4057qib7 7013 21 of of IN cord-005453-4057qib7 7013 22 PRES PRES NNP cord-005453-4057qib7 7013 23 occurrence occurrence NN cord-005453-4057qib7 7013 24 , , , cord-005453-4057qib7 7013 25 while while IN cord-005453-4057qib7 7013 26 CSA CSA NNP cord-005453-4057qib7 7013 27 was be VBD cord-005453-4057qib7 7013 28 stopped stop VBN cord-005453-4057qib7 7013 29 but but CC cord-005453-4057qib7 7013 30 MMF MMF NNP cord-005453-4057qib7 7013 31 continued continue VBD cord-005453-4057qib7 7013 32 in in IN cord-005453-4057qib7 7013 33 1 1 CD cord-005453-4057qib7 7013 34 patients patient NNS cord-005453-4057qib7 7013 35 taking take VBG cord-005453-4057qib7 7013 36 CSA CSA NNP cord-005453-4057qib7 7013 37 / / SYM cord-005453-4057qib7 7013 38 MMF MMF NNP cord-005453-4057qib7 7013 39 combination combination NN cord-005453-4057qib7 7013 40 and and CC cord-005453-4057qib7 7013 41 CSA CSA NNP cord-005453-4057qib7 7013 42 was be VBD cord-005453-4057qib7 7013 43 continued continue VBN cord-005453-4057qib7 7013 44 for for IN cord-005453-4057qib7 7013 45 1 1 CD cord-005453-4057qib7 7013 46 patient patient NN cord-005453-4057qib7 7013 47 . . . cord-005453-4057qib7 7014 1 Three three CD cord-005453-4057qib7 7014 2 patients patient NNS cord-005453-4057qib7 7014 3 with with IN cord-005453-4057qib7 7014 4 PRES PRES NNP cord-005453-4057qib7 7014 5 had have VBD cord-005453-4057qib7 7014 6 grade grade NN cord-005453-4057qib7 7014 7 2 2 CD cord-005453-4057qib7 7014 8 acute acute JJ cord-005453-4057qib7 7014 9 GVHD GVHD NNP cord-005453-4057qib7 7014 10 , , , cord-005453-4057qib7 7014 11 1 1 CD cord-005453-4057qib7 7014 12 had have VBD cord-005453-4057qib7 7014 13 grade grade NN cord-005453-4057qib7 7014 14 1 1 CD cord-005453-4057qib7 7014 15 GVHD GVHD NNP cord-005453-4057qib7 7014 16 and and CC cord-005453-4057qib7 7014 17 none none NN cord-005453-4057qib7 7014 18 developed develop VBD cord-005453-4057qib7 7014 19 chronic chronic JJ cord-005453-4057qib7 7014 20 GVHD GVHD NNP cord-005453-4057qib7 7014 21 . . . cord-005453-4057qib7 7015 1 CSA CSA NNP cord-005453-4057qib7 7015 2 levels level NNS cord-005453-4057qib7 7015 3 at at IN cord-005453-4057qib7 7015 4 the the DT cord-005453-4057qib7 7015 5 time time NN cord-005453-4057qib7 7015 6 of of IN cord-005453-4057qib7 7015 7 PRES PRES NNP cord-005453-4057qib7 7015 8 were be VBD cord-005453-4057qib7 7015 9 a a DT cord-005453-4057qib7 7015 10 median median NN cord-005453-4057qib7 7015 11 of of IN cord-005453-4057qib7 7015 12 133 133 CD cord-005453-4057qib7 7015 13 ng ng NN cord-005453-4057qib7 7015 14 / / SYM cord-005453-4057qib7 7015 15 mL ml NN cord-005453-4057qib7 7015 16 ( ( -LRB- cord-005453-4057qib7 7015 17 IQR iqr NN cord-005453-4057qib7 7015 18 : : : cord-005453-4057qib7 7015 19 89 89 CD cord-005453-4057qib7 7015 20 to194 to194 CD cord-005453-4057qib7 7015 21 ) ) -RRB- cord-005453-4057qib7 7015 22 with with IN cord-005453-4057qib7 7015 23 1 1 CD cord-005453-4057qib7 7015 24 patient patient NN cord-005453-4057qib7 7015 25 having have VBG cord-005453-4057qib7 7015 26 419 419 CD cord-005453-4057qib7 7015 27 ng ng NNP cord-005453-4057qib7 7015 28 / / SYM cord-005453-4057qib7 7015 29 mL. mL. NNP cord-005453-4057qib7 7015 30 Three three CD cord-005453-4057qib7 7015 31 patients patient NNS cord-005453-4057qib7 7015 32 had have VBD cord-005453-4057qib7 7015 33 PRES PRES NNP cord-005453-4057qib7 7015 34 while while IN cord-005453-4057qib7 7015 35 they -PRON- PRP cord-005453-4057qib7 7015 36 were be VBD cord-005453-4057qib7 7015 37 thrombocytopenic thrombocytopenic JJ cord-005453-4057qib7 7015 38 . . . cord-005453-4057qib7 7016 1 Hypertension hypertension NN cord-005453-4057qib7 7016 2 stage stage NN cord-005453-4057qib7 7016 3 2 2 CD cord-005453-4057qib7 7016 4 was be VBD cord-005453-4057qib7 7016 5 observed observe VBN cord-005453-4057qib7 7016 6 in in IN cord-005453-4057qib7 7016 7 four four CD cord-005453-4057qib7 7016 8 patients patient NNS cord-005453-4057qib7 7016 9 , , , cord-005453-4057qib7 7016 10 stage stage NN cord-005453-4057qib7 7016 11 1 1 CD cord-005453-4057qib7 7016 12 in in IN cord-005453-4057qib7 7016 13 one one CD cord-005453-4057qib7 7016 14 patient patient NN cord-005453-4057qib7 7016 15 , , , cord-005453-4057qib7 7016 16 one one CD cord-005453-4057qib7 7016 17 patient patient NN cord-005453-4057qib7 7016 18 was be VBD cord-005453-4057qib7 7016 19 not not RB cord-005453-4057qib7 7016 20 hypertensive hypertensive JJ cord-005453-4057qib7 7016 21 and and CC cord-005453-4057qib7 7016 22 in in IN cord-005453-4057qib7 7016 23 one one CD cord-005453-4057qib7 7016 24 patient patient JJ cord-005453-4057qib7 7016 25 blood blood NN cord-005453-4057qib7 7016 26 pressure pressure NN cord-005453-4057qib7 7016 27 values value NNS cord-005453-4057qib7 7016 28 were be VBD cord-005453-4057qib7 7016 29 not not RB cord-005453-4057qib7 7016 30 available available JJ cord-005453-4057qib7 7016 31 . . . cord-005453-4057qib7 7017 1 Two two CD cord-005453-4057qib7 7017 2 patients patient NNS cord-005453-4057qib7 7017 3 were be VBD cord-005453-4057qib7 7017 4 on on IN cord-005453-4057qib7 7017 5 methylprednisolone methylprednisolone NNP cord-005453-4057qib7 7017 6 1 1 CD cord-005453-4057qib7 7017 7 and and CC cord-005453-4057qib7 7017 8 1.3 1.3 CD cord-005453-4057qib7 7017 9 mg mg NNP cord-005453-4057qib7 7017 10 / / SYM cord-005453-4057qib7 7017 11 kg kg NNP cord-005453-4057qib7 7017 12 / / SYM cord-005453-4057qib7 7017 13 day day NN cord-005453-4057qib7 7017 14 and and CC cord-005453-4057qib7 7017 15 one one CD cord-005453-4057qib7 7017 16 was be VBD cord-005453-4057qib7 7017 17 on on IN cord-005453-4057qib7 7017 18 dexamethasone dexamethasone NNP cord-005453-4057qib7 7017 19 10 10 CD cord-005453-4057qib7 7017 20 mg mg NNP cord-005453-4057qib7 7017 21 / / SYM cord-005453-4057qib7 7017 22 m2 m2 NNP cord-005453-4057qib7 7017 23 / / SYM cord-005453-4057qib7 7017 24 day day NN cord-005453-4057qib7 7017 25 . . . cord-005453-4057qib7 7018 1 One one CD cord-005453-4057qib7 7018 2 patient patient NN cord-005453-4057qib7 7018 3 was be VBD cord-005453-4057qib7 7018 4 started start VBN cord-005453-4057qib7 7018 5 on on IN cord-005453-4057qib7 7018 6 CSA CSA NNP cord-005453-4057qib7 7018 7 again again RB cord-005453-4057qib7 7018 8 after after IN cord-005453-4057qib7 7018 9 the the DT cord-005453-4057qib7 7018 10 PRES PRES NNP cord-005453-4057qib7 7018 11 episode episode NN cord-005453-4057qib7 7018 12 and and CC cord-005453-4057qib7 7018 13 within within IN cord-005453-4057qib7 7018 14 2 2 CD cord-005453-4057qib7 7018 15 weeks week NNS cord-005453-4057qib7 7018 16 had have VBD cord-005453-4057qib7 7018 17 another another DT cord-005453-4057qib7 7018 18 one one NN cord-005453-4057qib7 7018 19 while while NN cord-005453-4057qib7 7018 20 on on IN cord-005453-4057qib7 7018 21 CSA CSA NNP cord-005453-4057qib7 7018 22 ( ( -LRB- cord-005453-4057qib7 7018 23 level level NN cord-005453-4057qib7 7018 24 30 30 CD cord-005453-4057qib7 7018 25 ng(mL ng(ml CD cord-005453-4057qib7 7018 26 ) ) -RRB- cord-005453-4057qib7 7018 27 , , , cord-005453-4057qib7 7018 28 methylprednisolone methylprednisolone NNP cord-005453-4057qib7 7018 29 1.5 1.5 CD cord-005453-4057qib7 7018 30 mg mg NNP cord-005453-4057qib7 7018 31 / / SYM cord-005453-4057qib7 7018 32 kg kg NNP cord-005453-4057qib7 7018 33 / / SYM cord-005453-4057qib7 7018 34 day day NN cord-005453-4057qib7 7018 35 and and CC cord-005453-4057qib7 7018 36 Ruxolitinib Ruxolitinib NNP cord-005453-4057qib7 7018 37 for for IN cord-005453-4057qib7 7018 38 GVHD GVHD NNP cord-005453-4057qib7 7018 39 . . . cord-005453-4057qib7 7019 1 Protocol protocol NN cord-005453-4057qib7 7019 2 2 2 CD cord-005453-4057qib7 7019 3 had have VBD cord-005453-4057qib7 7019 4 statistically statistically RB cord-005453-4057qib7 7019 5 significant significant JJ cord-005453-4057qib7 7019 6 improvement improvement NN cord-005453-4057qib7 7019 7 in in IN cord-005453-4057qib7 7019 8 disease disease NN cord-005453-4057qib7 7019 9 free free JJ cord-005453-4057qib7 7019 10 survival survival NN cord-005453-4057qib7 7019 11 from from IN cord-005453-4057qib7 7019 12 67 67 CD cord-005453-4057qib7 7019 13 % % NN cord-005453-4057qib7 7019 14 to to IN cord-005453-4057qib7 7019 15 91 91 CD cord-005453-4057qib7 7019 16 % % NN cord-005453-4057qib7 7019 17 ( ( -LRB- cord-005453-4057qib7 7019 18 p p NN cord-005453-4057qib7 7019 19 < < XX cord-005453-4057qib7 7019 20 0.001 0.001 CD cord-005453-4057qib7 7019 21 ) ) -RRB- cord-005453-4057qib7 7019 22 with with IN cord-005453-4057qib7 7019 23 probability probability NN cord-005453-4057qib7 7019 24 of of IN cord-005453-4057qib7 7019 25 occurrence occurrence NN cord-005453-4057qib7 7019 26 of of IN cord-005453-4057qib7 7019 27 PRES PRES NNP cord-005453-4057qib7 7019 28 increasing increase VBG cord-005453-4057qib7 7019 29 from from IN cord-005453-4057qib7 7019 30 1.4 1.4 CD cord-005453-4057qib7 7019 31 % % NN cord-005453-4057qib7 7019 32 to to IN cord-005453-4057qib7 7019 33 5.0 5.0 CD cord-005453-4057qib7 7019 34 % % NN cord-005453-4057qib7 7019 35 ( ( -LRB- cord-005453-4057qib7 7019 36 P p NN cord-005453-4057qib7 7019 37 = = SYM cord-005453-4057qib7 7019 38 0.17 0.17 CD cord-005453-4057qib7 7019 39 , , , cord-005453-4057qib7 7019 40 see see VB cord-005453-4057qib7 7019 41 Figure figure NN cord-005453-4057qib7 7019 42 1 1 CD cord-005453-4057qib7 7019 43 ) ) -RRB- cord-005453-4057qib7 7019 44 , , , cord-005453-4057qib7 7019 45 yet yet CC cord-005453-4057qib7 7019 46 had have VBD cord-005453-4057qib7 7019 47 a a DT cord-005453-4057qib7 7019 48 benign benign JJ cord-005453-4057qib7 7019 49 course course NN cord-005453-4057qib7 7019 50 in in IN cord-005453-4057qib7 7019 51 all all DT cord-005453-4057qib7 7019 52 patients patient NNS cord-005453-4057qib7 7019 53 . . . cord-005453-4057qib7 7020 1 Conclusions conclusion NNS cord-005453-4057qib7 7020 2 : : : cord-005453-4057qib7 7021 1 Not not RB cord-005453-4057qib7 7021 2 stopping stop VBG cord-005453-4057qib7 7021 3 immunosuppression immunosuppression NN cord-005453-4057qib7 7021 4 may may MD cord-005453-4057qib7 7021 5 have have VB cord-005453-4057qib7 7021 6 been be VBN cord-005453-4057qib7 7021 7 the the DT cord-005453-4057qib7 7021 8 key key JJ cord-005453-4057qib7 7021 9 factor factor NN cord-005453-4057qib7 7021 10 which which WDT cord-005453-4057qib7 7021 11 could could MD cord-005453-4057qib7 7021 12 explain explain VB cord-005453-4057qib7 7021 13 why why WRB cord-005453-4057qib7 7021 14 we -PRON- PRP cord-005453-4057qib7 7021 15 have have VBP cord-005453-4057qib7 7021 16 better well JJR cord-005453-4057qib7 7021 17 outcomes outcome NNS cord-005453-4057qib7 7021 18 with with IN cord-005453-4057qib7 7021 19 PRES PRES NNP cord-005453-4057qib7 7021 20 than than IN cord-005453-4057qib7 7021 21 what what WP cord-005453-4057qib7 7021 22 is be VBZ cord-005453-4057qib7 7021 23 reported report VBN cord-005453-4057qib7 7021 24 . . . cord-005453-4057qib7 7022 1 Intensifying intensify VBG cord-005453-4057qib7 7022 2 immunosuppression immunosuppression NN cord-005453-4057qib7 7022 3 pre pre JJ cord-005453-4057qib7 7022 4 - - NN cord-005453-4057qib7 7022 5 BMT BMT NNP cord-005453-4057qib7 7022 6 did do VBD cord-005453-4057qib7 7022 7 lead lead VB cord-005453-4057qib7 7022 8 to to IN cord-005453-4057qib7 7022 9 more more JJR cord-005453-4057qib7 7022 10 PRES PRES NNP cord-005453-4057qib7 7022 11 , , , cord-005453-4057qib7 7022 12 albeit albeit IN cord-005453-4057qib7 7022 13 not not RB cord-005453-4057qib7 7022 14 significantly significantly RB cord-005453-4057qib7 7022 15 , , , cord-005453-4057qib7 7022 16 and and CC cord-005453-4057qib7 7022 17 yet yet RB cord-005453-4057qib7 7022 18 it -PRON- PRP cord-005453-4057qib7 7022 19 was be VBD cord-005453-4057qib7 7022 20 quite quite RB cord-005453-4057qib7 7022 21 manageable manageable JJ cord-005453-4057qib7 7022 22 . . . cord-005453-4057qib7 7023 1 Even even RB cord-005453-4057qib7 7023 2 with with IN cord-005453-4057qib7 7023 3 addition addition NN cord-005453-4057qib7 7023 4 of of IN cord-005453-4057qib7 7023 5 fludarabine fludarabine NN cord-005453-4057qib7 7023 6 our -PRON- PRP$ cord-005453-4057qib7 7023 7 PRES PRES NNP cord-005453-4057qib7 7023 8 incidence incidence NN cord-005453-4057qib7 7023 9 is be VBZ cord-005453-4057qib7 7023 10 lower low JJR cord-005453-4057qib7 7023 11 than than IN cord-005453-4057qib7 7023 12 previously previously RB cord-005453-4057qib7 7023 13 reported report VBN cord-005453-4057qib7 7023 14 . . . cord-005453-4057qib7 7024 1 [ [ -LRB- cord-005453-4057qib7 7024 2 [ [ -LRB- cord-005453-4057qib7 7024 3 P320 P320 NNP cord-005453-4057qib7 7024 4 Image image NN cord-005453-4057qib7 7024 5 ] ] -RRB- cord-005453-4057qib7 7024 6 1 1 CD cord-005453-4057qib7 7024 7 . . . cord-005453-4057qib7 7025 1 Background background NN cord-005453-4057qib7 7025 2 : : : cord-005453-4057qib7 7026 1 Sickle sickle NN cord-005453-4057qib7 7026 2 - - HYPH cord-005453-4057qib7 7026 3 cell cell NN cord-005453-4057qib7 7026 4 diseases disease NNS cord-005453-4057qib7 7026 5 ( ( -LRB- cord-005453-4057qib7 7026 6 SCD SCD NNP cord-005453-4057qib7 7026 7 ) ) -RRB- cord-005453-4057qib7 7026 8 are be VBP cord-005453-4057qib7 7026 9 a a DT cord-005453-4057qib7 7026 10 group group NN cord-005453-4057qib7 7026 11 of of IN cord-005453-4057qib7 7026 12 genetic genetic JJ cord-005453-4057qib7 7026 13 hemoglobin hemoglobin NN cord-005453-4057qib7 7026 14 disorders disorder NNS cord-005453-4057qib7 7026 15 marked mark VBN cord-005453-4057qib7 7026 16 by by IN cord-005453-4057qib7 7026 17 brain brain NN cord-005453-4057qib7 7026 18 vasculopathy vasculopathy NNP cord-005453-4057qib7 7026 19 . . . cord-005453-4057qib7 7027 1 Allogeneic allogeneic IN cord-005453-4057qib7 7027 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 7027 3 stem stem NN cord-005453-4057qib7 7027 4 cell cell NN cord-005453-4057qib7 7027 5 transplantation transplantation NN cord-005453-4057qib7 7027 6 ( ( -LRB- cord-005453-4057qib7 7027 7 HSCT HSCT NNP cord-005453-4057qib7 7027 8 ) ) -RRB- cord-005453-4057qib7 7027 9 is be VBZ cord-005453-4057qib7 7027 10 a a DT cord-005453-4057qib7 7027 11 curative curative JJ cord-005453-4057qib7 7027 12 option option NN cord-005453-4057qib7 7027 13 able able JJ cord-005453-4057qib7 7027 14 to to TO cord-005453-4057qib7 7027 15 stop stop VB cord-005453-4057qib7 7027 16 vascular vascular JJ cord-005453-4057qib7 7027 17 disease disease NN cord-005453-4057qib7 7027 18 progression progression NN cord-005453-4057qib7 7027 19 . . . cord-005453-4057qib7 7028 1 Diffusion diffusion NN cord-005453-4057qib7 7028 2 - - HYPH cord-005453-4057qib7 7028 3 tensor tensor NN cord-005453-4057qib7 7028 4 imaging imaging NN cord-005453-4057qib7 7028 5 ( ( -LRB- cord-005453-4057qib7 7028 6 DTI DTI NNP cord-005453-4057qib7 7028 7 ) ) -RRB- cord-005453-4057qib7 7028 8 is be VBZ cord-005453-4057qib7 7028 9 a a DT cord-005453-4057qib7 7028 10 magnetic magnetic JJ cord-005453-4057qib7 7028 11 resonance resonance NN cord-005453-4057qib7 7028 12 imaging imaging NN cord-005453-4057qib7 7028 13 ( ( -LRB- cord-005453-4057qib7 7028 14 MRI MRI NNP cord-005453-4057qib7 7028 15 ) ) -RRB- cord-005453-4057qib7 7028 16 technique technique NN cord-005453-4057qib7 7028 17 sensitive sensitive JJ cord-005453-4057qib7 7028 18 to to IN cord-005453-4057qib7 7028 19 the the DT cord-005453-4057qib7 7028 20 Brownian Brownian NNP cord-005453-4057qib7 7028 21 motion motion NN cord-005453-4057qib7 7028 22 of of IN cord-005453-4057qib7 7028 23 water water NN cord-005453-4057qib7 7028 24 molecules molecule NNS cord-005453-4057qib7 7028 25 and and CC cord-005453-4057qib7 7028 26 cellular cellular JJ cord-005453-4057qib7 7028 27 environment environment NN cord-005453-4057qib7 7028 28 . . . cord-005453-4057qib7 7029 1 This this DT cord-005453-4057qib7 7029 2 microscopic microscopic JJ cord-005453-4057qib7 7029 3 quantitative quantitative JJ cord-005453-4057qib7 7029 4 technique technique NN cord-005453-4057qib7 7029 5 is be VBZ cord-005453-4057qib7 7029 6 able able JJ cord-005453-4057qib7 7029 7 to to TO cord-005453-4057qib7 7029 8 detect detect VB cord-005453-4057qib7 7029 9 white white JJ cord-005453-4057qib7 7029 10 matter matter NN cord-005453-4057qib7 7029 11 ( ( -LRB- cord-005453-4057qib7 7029 12 WM WM NNP cord-005453-4057qib7 7029 13 ) ) -RRB- cord-005453-4057qib7 7029 14 alterations alteration NNS cord-005453-4057qib7 7029 15 before before IN cord-005453-4057qib7 7029 16 a a DT cord-005453-4057qib7 7029 17 conventional conventional JJ cord-005453-4057qib7 7029 18 MRI mri NN cord-005453-4057qib7 7029 19 . . . cord-005453-4057qib7 7030 1 The the DT cord-005453-4057qib7 7030 2 aim aim NN cord-005453-4057qib7 7030 3 of of IN cord-005453-4057qib7 7030 4 this this DT cord-005453-4057qib7 7030 5 study study NN cord-005453-4057qib7 7030 6 was be VBD cord-005453-4057qib7 7030 7 to to TO cord-005453-4057qib7 7030 8 use use VB cord-005453-4057qib7 7030 9 DTI DTI NNP cord-005453-4057qib7 7030 10 to to TO cord-005453-4057qib7 7030 11 evaluate evaluate VB cord-005453-4057qib7 7030 12 axonal axonal JJ cord-005453-4057qib7 7030 13 damage damage NN cord-005453-4057qib7 7030 14 and and CC cord-005453-4057qib7 7030 15 structural structural JJ cord-005453-4057qib7 7030 16 connectivity connectivity NN cord-005453-4057qib7 7030 17 in in IN cord-005453-4057qib7 7030 18 the the DT cord-005453-4057qib7 7030 19 brain brain NN cord-005453-4057qib7 7030 20 of of IN cord-005453-4057qib7 7030 21 patients patient NNS cord-005453-4057qib7 7030 22 with with IN cord-005453-4057qib7 7030 23 SCD SCD NNP cord-005453-4057qib7 7030 24 submitted submit VBN cord-005453-4057qib7 7030 25 to to IN cord-005453-4057qib7 7030 26 HLA HLA NNP cord-005453-4057qib7 7030 27 - - HYPH cord-005453-4057qib7 7030 28 identical identical JJ cord-005453-4057qib7 7030 29 sibling sibling NN cord-005453-4057qib7 7030 30 allogeneic allogeneic NN cord-005453-4057qib7 7030 31 HSCT HSCT NNP cord-005453-4057qib7 7030 32 . . . cord-005453-4057qib7 7031 1 Methods method NNS cord-005453-4057qib7 7031 2 : : : cord-005453-4057qib7 7032 1 Sixteen sixteen JJ cord-005453-4057qib7 7032 2 SCD SCD NNP cord-005453-4057qib7 7032 3 patients patient NNS cord-005453-4057qib7 7032 4 with with IN cord-005453-4057qib7 7032 5 no no DT cord-005453-4057qib7 7032 6 extensive extensive JJ cord-005453-4057qib7 7032 7 vasculopathy vasculopathy NN cord-005453-4057qib7 7032 8 detected detect VBN cord-005453-4057qib7 7032 9 by by IN cord-005453-4057qib7 7032 10 conventional conventional JJ cord-005453-4057qib7 7032 11 MRI MRI NNP cord-005453-4057qib7 7032 12 ( ( -LRB- cord-005453-4057qib7 7032 13 11 11 CD cord-005453-4057qib7 7032 14 male male NN cord-005453-4057qib7 7032 15 , , , cord-005453-4057qib7 7032 16 age age NN cord-005453-4057qib7 7032 17 range range NN cord-005453-4057qib7 7032 18 : : : cord-005453-4057qib7 7032 19 9 9 CD cord-005453-4057qib7 7032 20 -33 -33 NNS cord-005453-4057qib7 7032 21 years year NNS cord-005453-4057qib7 7032 22 ) ) -RRB- cord-005453-4057qib7 7032 23 and and CC cord-005453-4057qib7 7032 24 17 17 CD cord-005453-4057qib7 7032 25 age age NN cord-005453-4057qib7 7032 26 - - HYPH cord-005453-4057qib7 7032 27 matched match VBN cord-005453-4057qib7 7032 28 healthy healthy JJ cord-005453-4057qib7 7032 29 controls control NNS cord-005453-4057qib7 7032 30 ( ( -LRB- cord-005453-4057qib7 7032 31 10 10 CD cord-005453-4057qib7 7032 32 male male NN cord-005453-4057qib7 7032 33 , , , cord-005453-4057qib7 7032 34 age age NN cord-005453-4057qib7 7032 35 range range NN cord-005453-4057qib7 7032 36 : : : cord-005453-4057qib7 7032 37 6 6 CD cord-005453-4057qib7 7032 38 -31 -31 CD cord-005453-4057qib7 7032 39 years year NNS cord-005453-4057qib7 7032 40 ) ) -RRB- cord-005453-4057qib7 7032 41 participated participate VBD cord-005453-4057qib7 7032 42 in in IN cord-005453-4057qib7 7032 43 this this DT cord-005453-4057qib7 7032 44 prospective prospective JJ cord-005453-4057qib7 7032 45 study study NN cord-005453-4057qib7 7032 46 . . . cord-005453-4057qib7 7033 1 MRI MRI NNP cord-005453-4057qib7 7033 2 acquisitions acquisition NNS cord-005453-4057qib7 7033 3 were be VBD cord-005453-4057qib7 7033 4 performed perform VBN cord-005453-4057qib7 7033 5 in in IN cord-005453-4057qib7 7033 6 a a DT cord-005453-4057qib7 7033 7 3 3 CD cord-005453-4057qib7 7033 8 T t NN cord-005453-4057qib7 7033 9 scanner scanner NN cord-005453-4057qib7 7033 10 two two CD cord-005453-4057qib7 7033 11 times time NNS cord-005453-4057qib7 7033 12 for for IN cord-005453-4057qib7 7033 13 patients patient NNS cord-005453-4057qib7 7033 14 ( ( -LRB- cord-005453-4057qib7 7033 15 before before IN cord-005453-4057qib7 7033 16 and and CC cord-005453-4057qib7 7033 17 1 1 CD cord-005453-4057qib7 7033 18 - - SYM cord-005453-4057qib7 7033 19 5 5 CD cord-005453-4057qib7 7033 20 years year NNS cord-005453-4057qib7 7033 21 after after IN cord-005453-4057qib7 7033 22 HSCT HSCT NNP cord-005453-4057qib7 7033 23 ) ) -RRB- cord-005453-4057qib7 7033 24 and and CC cord-005453-4057qib7 7033 25 at at IN cord-005453-4057qib7 7033 26 a a DT cord-005453-4057qib7 7033 27 single single JJ cord-005453-4057qib7 7033 28 moment moment NN cord-005453-4057qib7 7033 29 for for IN cord-005453-4057qib7 7033 30 controls control NNS cord-005453-4057qib7 7033 31 . . . cord-005453-4057qib7 7034 1 From from IN cord-005453-4057qib7 7034 2 DTI DTI NNP cord-005453-4057qib7 7034 3 acquisitions acquisition NNS cord-005453-4057qib7 7034 4 , , , cord-005453-4057qib7 7034 5 fractional fractional JJ cord-005453-4057qib7 7034 6 anisotropy anisotropy NN cord-005453-4057qib7 7034 7 ( ( -LRB- cord-005453-4057qib7 7034 8 FA FA NNP cord-005453-4057qib7 7034 9 ) ) -RRB- cord-005453-4057qib7 7034 10 , , , cord-005453-4057qib7 7034 11 mean mean JJ cord-005453-4057qib7 7034 12 ( ( -LRB- cord-005453-4057qib7 7034 13 MD MD NNP cord-005453-4057qib7 7034 14 ) ) -RRB- cord-005453-4057qib7 7034 15 , , , cord-005453-4057qib7 7034 16 radial radial JJ cord-005453-4057qib7 7034 17 ( ( -LRB- cord-005453-4057qib7 7034 18 RD RD NNP cord-005453-4057qib7 7034 19 ) ) -RRB- cord-005453-4057qib7 7034 20 and and CC cord-005453-4057qib7 7034 21 axial axial JJ cord-005453-4057qib7 7034 22 diffusibility diffusibility NN cord-005453-4057qib7 7034 23 ( ( -LRB- cord-005453-4057qib7 7034 24 AD ad NN cord-005453-4057qib7 7034 25 ) ) -RRB- cord-005453-4057qib7 7034 26 were be VBD cord-005453-4057qib7 7034 27 calculated calculate VBN cord-005453-4057qib7 7034 28 in in IN cord-005453-4057qib7 7034 29 the the DT cord-005453-4057qib7 7034 30 WM WM NNP cord-005453-4057qib7 7034 31 of of IN cord-005453-4057qib7 7034 32 the the DT cord-005453-4057qib7 7034 33 whole whole JJ cord-005453-4057qib7 7034 34 brain brain NN cord-005453-4057qib7 7034 35 . . . cord-005453-4057qib7 7035 1 Structural structural JJ cord-005453-4057qib7 7035 2 connectivity connectivity NN cord-005453-4057qib7 7035 3 was be VBD cord-005453-4057qib7 7035 4 also also RB cord-005453-4057qib7 7035 5 analyzed analyze VBN cord-005453-4057qib7 7035 6 , , , cord-005453-4057qib7 7035 7 based base VBN cord-005453-4057qib7 7035 8 on on IN cord-005453-4057qib7 7035 9 graph graph NN cord-005453-4057qib7 7035 10 theory theory NN cord-005453-4057qib7 7035 11 , , , cord-005453-4057qib7 7035 12 obtaining obtain VBG cord-005453-4057qib7 7035 13 efficiency efficiency NN cord-005453-4057qib7 7035 14 , , , cord-005453-4057qib7 7035 15 length length NN cord-005453-4057qib7 7035 16 path path NN cord-005453-4057qib7 7035 17 and and CC cord-005453-4057qib7 7035 18 clustering clustering NN cord-005453-4057qib7 7035 19 coefficients coefficient NNS cord-005453-4057qib7 7035 20 of of IN cord-005453-4057qib7 7035 21 the the DT cord-005453-4057qib7 7035 22 brain brain NN cord-005453-4057qib7 7035 23 network network NN cord-005453-4057qib7 7035 24 . . . cord-005453-4057qib7 7036 1 An an DT cord-005453-4057qib7 7036 2 ANOVA anova NN cord-005453-4057qib7 7036 3 test test NN cord-005453-4057qib7 7036 4 was be VBD cord-005453-4057qib7 7036 5 applied apply VBN cord-005453-4057qib7 7036 6 to to TO cord-005453-4057qib7 7036 7 analyze analyze VB cord-005453-4057qib7 7036 8 FA FA NNP cord-005453-4057qib7 7036 9 differences difference NNS cord-005453-4057qib7 7036 10 among among IN cord-005453-4057qib7 7036 11 controls control NNS cord-005453-4057qib7 7036 12 and and CC cord-005453-4057qib7 7036 13 patients patient NNS cord-005453-4057qib7 7036 14 , , , cord-005453-4057qib7 7036 15 before before IN cord-005453-4057qib7 7036 16 and and CC cord-005453-4057qib7 7036 17 after after IN cord-005453-4057qib7 7036 18 HSCT HSCT NNP cord-005453-4057qib7 7036 19 . . . cord-005453-4057qib7 7037 1 A a DT cord-005453-4057qib7 7037 2 paired paired JJ cord-005453-4057qib7 7037 3 two two CD cord-005453-4057qib7 7037 4 - - HYPH cord-005453-4057qib7 7037 5 tailed tailed JJ cord-005453-4057qib7 7037 6 t t NN cord-005453-4057qib7 7037 7 - - HYPH cord-005453-4057qib7 7037 8 test test NN cord-005453-4057qib7 7037 9 was be VBD cord-005453-4057qib7 7037 10 used use VBN cord-005453-4057qib7 7037 11 to to TO cord-005453-4057qib7 7037 12 determine determine VB cord-005453-4057qib7 7037 13 statistical statistical JJ cord-005453-4057qib7 7037 14 significance significance NN cord-005453-4057qib7 7037 15 of of IN cord-005453-4057qib7 7037 16 changes change NNS cord-005453-4057qib7 7037 17 in in IN cord-005453-4057qib7 7037 18 the the DT cord-005453-4057qib7 7037 19 FA fa NN cord-005453-4057qib7 7037 20 , , , cord-005453-4057qib7 7037 21 diffusivity diffusivity NN cord-005453-4057qib7 7037 22 mean mean VB cord-005453-4057qib7 7037 23 values value NNS cord-005453-4057qib7 7037 24 and and CC cord-005453-4057qib7 7037 25 network network NN cord-005453-4057qib7 7037 26 parameters parameter NNS cord-005453-4057qib7 7037 27 before before IN cord-005453-4057qib7 7037 28 and and CC cord-005453-4057qib7 7037 29 after after IN cord-005453-4057qib7 7037 30 HSCT HSCT NNP cord-005453-4057qib7 7037 31 . . . cord-005453-4057qib7 7038 1 Results result NNS cord-005453-4057qib7 7038 2 : : : cord-005453-4057qib7 7039 1 Mean mean JJ cord-005453-4057qib7 7039 2 FA FA NNP cord-005453-4057qib7 7039 3 was be VBD cord-005453-4057qib7 7039 4 lower low JJR cord-005453-4057qib7 7039 5 in in IN cord-005453-4057qib7 7039 6 patients patient NNS cord-005453-4057qib7 7039 7 before before IN cord-005453-4057qib7 7039 8 HSCT HSCT NNP cord-005453-4057qib7 7039 9 than than IN cord-005453-4057qib7 7039 10 controls control NNS cord-005453-4057qib7 7040 1 ( ( -LRB- cord-005453-4057qib7 7040 2 p p NN cord-005453-4057qib7 7040 3 = = SYM cord-005453-4057qib7 7040 4 0,038 0,038 CD cord-005453-4057qib7 7040 5 ) ) -RRB- cord-005453-4057qib7 7040 6 and and CC cord-005453-4057qib7 7040 7 increased increase VBD cord-005453-4057qib7 7040 8 after after IN cord-005453-4057qib7 7040 9 HSCT HSCT NNP cord-005453-4057qib7 7040 10 being be VBG cord-005453-4057qib7 7040 11 not not RB cord-005453-4057qib7 7040 12 statistically statistically RB cord-005453-4057qib7 7040 13 different different JJ cord-005453-4057qib7 7040 14 when when WRB cord-005453-4057qib7 7040 15 compared compare VBN cord-005453-4057qib7 7040 16 to to IN cord-005453-4057qib7 7040 17 controls control NNS cord-005453-4057qib7 7040 18 ( ( -LRB- cord-005453-4057qib7 7040 19 controls control NNS cord-005453-4057qib7 7040 20 = = NNP cord-005453-4057qib7 7040 21 0,3504 0,3504 NNP cord-005453-4057qib7 7040 22 ; ; : cord-005453-4057qib7 7040 23 patients patient NNS cord-005453-4057qib7 7040 24 before before IN cord-005453-4057qib7 7040 25 HSCT HSCT NNP cord-005453-4057qib7 7040 26 = = SYM cord-005453-4057qib7 7040 27 0,3328 0,3328 NNP cord-005453-4057qib7 7040 28 ; ; : cord-005453-4057qib7 7040 29 patients patient NNS cord-005453-4057qib7 7040 30 after after IN cord-005453-4057qib7 7040 31 HSCT HSCT NNP cord-005453-4057qib7 7040 32 = = NFP cord-005453-4057qib7 7041 1 0,3422 0,3422 LS cord-005453-4057qib7 7041 2 ; ; : cord-005453-4057qib7 7041 3 Post Post NNP cord-005453-4057qib7 7041 4 hoc hoc FW cord-005453-4057qib7 7041 5 Dunnett Dunnett NNP cord-005453-4057qib7 7041 6 's 's POS cord-005453-4057qib7 7041 7 test test NN cord-005453-4057qib7 7041 8 -Error -Error . cord-005453-4057qib7 7041 9 0,03 0,03 XX cord-005453-4057qib7 7041 10 ; ; : cord-005453-4057qib7 7041 11 ANOVA ANOVA NNP cord-005453-4057qib7 7041 12 test test NN cord-005453-4057qib7 7041 13 ) ) -RRB- cord-005453-4057qib7 7041 14 . . . cord-005453-4057qib7 7042 1 When when WRB cord-005453-4057qib7 7042 2 patients patient NNS cord-005453-4057qib7 7042 3 were be VBD cord-005453-4057qib7 7042 4 compared compare VBN cord-005453-4057qib7 7042 5 before before IN cord-005453-4057qib7 7042 6 and and CC cord-005453-4057qib7 7042 7 after after IN cord-005453-4057qib7 7042 8 HSCT HSCT NNP cord-005453-4057qib7 7042 9 , , , cord-005453-4057qib7 7042 10 MD MD NNP cord-005453-4057qib7 7042 11 and and CC cord-005453-4057qib7 7042 12 RD RD NNP cord-005453-4057qib7 7042 13 decrease decrease NN cord-005453-4057qib7 7042 14 after after IN cord-005453-4057qib7 7042 15 HSCT HSCT NNP cord-005453-4057qib7 7042 16 ( ( -LRB- cord-005453-4057qib7 7042 17 p p NN cord-005453-4057qib7 7043 1 = = LS cord-005453-4057qib7 7043 2 0,038 0,038 CD cord-005453-4057qib7 7043 3 and and CC cord-005453-4057qib7 7043 4 0,047 0,047 CD cord-005453-4057qib7 7043 5 , , , cord-005453-4057qib7 7043 6 respectively respectively RB cord-005453-4057qib7 7043 7 ) ) -RRB- cord-005453-4057qib7 7043 8 . . . cord-005453-4057qib7 7044 1 On on IN cord-005453-4057qib7 7044 2 the the DT cord-005453-4057qib7 7044 3 other other JJ cord-005453-4057qib7 7044 4 hand hand NN cord-005453-4057qib7 7044 5 , , , cord-005453-4057qib7 7044 6 FA FA NNP cord-005453-4057qib7 7044 7 increased increase VBD cord-005453-4057qib7 7044 8 ( ( -LRB- cord-005453-4057qib7 7044 9 p p NN cord-005453-4057qib7 7044 10 = = SYM cord-005453-4057qib7 7044 11 0,044 0,044 CD cord-005453-4057qib7 7044 12 ) ) -RRB- cord-005453-4057qib7 7044 13 . . . cord-005453-4057qib7 7045 1 After after IN cord-005453-4057qib7 7045 2 HSCT HSCT NNP cord-005453-4057qib7 7045 3 , , , cord-005453-4057qib7 7045 4 efficiency efficiency NN cord-005453-4057qib7 7045 5 was be VBD cord-005453-4057qib7 7045 6 higher high JJR cord-005453-4057qib7 7045 7 ( ( -LRB- cord-005453-4057qib7 7045 8 p p NN cord-005453-4057qib7 7045 9 = = SYM cord-005453-4057qib7 7045 10 0,023 0,023 CD cord-005453-4057qib7 7045 11 ) ) -RRB- cord-005453-4057qib7 7045 12 and and CC cord-005453-4057qib7 7045 13 path path NN cord-005453-4057qib7 7045 14 length length NN cord-005453-4057qib7 7045 15 index index NN cord-005453-4057qib7 7045 16 was be VBD cord-005453-4057qib7 7045 17 lower low JJR cord-005453-4057qib7 7045 18 ( ( -LRB- cord-005453-4057qib7 7045 19 p=0,027 p=0,027 NNP cord-005453-4057qib7 7045 20 ) ) -RRB- cord-005453-4057qib7 7045 21 than than IN cord-005453-4057qib7 7045 22 at at IN cord-005453-4057qib7 7045 23 study study NN cord-005453-4057qib7 7045 24 entry entry NN cord-005453-4057qib7 7045 25 ( ( -LRB- cord-005453-4057qib7 7045 26 table table NN cord-005453-4057qib7 7045 27 1 1 CD cord-005453-4057qib7 7045 28 ) ) -RRB- cord-005453-4057qib7 7045 29 . . . cord-005453-4057qib7 7046 1 Conclusions conclusion NNS cord-005453-4057qib7 7046 2 : : : cord-005453-4057qib7 7047 1 This this DT cord-005453-4057qib7 7047 2 study study NN cord-005453-4057qib7 7047 3 indicates indicate VBZ cord-005453-4057qib7 7047 4 that that IN cord-005453-4057qib7 7047 5 , , , cord-005453-4057qib7 7047 6 before before IN cord-005453-4057qib7 7047 7 HSCT HSCT NNP cord-005453-4057qib7 7047 8 , , , cord-005453-4057qib7 7047 9 patients patient NNS cord-005453-4057qib7 7047 10 with with IN cord-005453-4057qib7 7047 11 SCD SCD NNP cord-005453-4057qib7 7047 12 present present JJ cord-005453-4057qib7 7047 13 axonal axonal JJ cord-005453-4057qib7 7047 14 damage damage NN cord-005453-4057qib7 7047 15 not not RB cord-005453-4057qib7 7047 16 detectable detectable JJ cord-005453-4057qib7 7047 17 by by IN cord-005453-4057qib7 7047 18 conventional conventional JJ cord-005453-4057qib7 7047 19 MRI mri NN cord-005453-4057qib7 7047 20 , , , cord-005453-4057qib7 7047 21 when when WRB cord-005453-4057qib7 7047 22 compared compare VBN cord-005453-4057qib7 7047 23 to to IN cord-005453-4057qib7 7047 24 healthy healthy JJ cord-005453-4057qib7 7047 25 controls control NNS cord-005453-4057qib7 7047 26 . . . cord-005453-4057qib7 7048 1 We -PRON- PRP cord-005453-4057qib7 7048 2 also also RB cord-005453-4057qib7 7048 3 suggest suggest VBP cord-005453-4057qib7 7048 4 that that IN cord-005453-4057qib7 7048 5 HSCT HSCT NNP cord-005453-4057qib7 7048 6 is be VBZ cord-005453-4057qib7 7048 7 able able JJ cord-005453-4057qib7 7048 8 to to TO cord-005453-4057qib7 7048 9 promote promote VB cord-005453-4057qib7 7048 10 axonal axonal JJ cord-005453-4057qib7 7048 11 recovery recovery NN cord-005453-4057qib7 7048 12 and and CC cord-005453-4057qib7 7048 13 reorganization reorganization NN cord-005453-4057qib7 7048 14 . . . cord-005453-4057qib7 7049 1 Partial partial JJ cord-005453-4057qib7 7049 2 diffusivity diffusivity NN cord-005453-4057qib7 7049 3 recovery recovery NN cord-005453-4057qib7 7049 4 could could MD cord-005453-4057qib7 7049 5 be be VB cord-005453-4057qib7 7049 6 associate associate JJ cord-005453-4057qib7 7049 7 to to IN cord-005453-4057qib7 7049 8 a a DT cord-005453-4057qib7 7049 9 still still RB cord-005453-4057qib7 7049 10 unidentified unidentified JJ cord-005453-4057qib7 7049 11 mechanism mechanism NN cord-005453-4057qib7 7049 12 of of IN cord-005453-4057qib7 7049 13 myelin myelin JJ cord-005453-4057qib7 7049 14 regeneration regeneration NN cord-005453-4057qib7 7049 15 . . . cord-005453-4057qib7 7050 1 In in IN cord-005453-4057qib7 7050 2 the the DT cord-005453-4057qib7 7050 3 future future NN cord-005453-4057qib7 7050 4 , , , cord-005453-4057qib7 7050 5 longer longer RB cord-005453-4057qib7 7050 6 follow follow VB cord-005453-4057qib7 7050 7 up up RP cord-005453-4057qib7 7050 8 and and CC cord-005453-4057qib7 7050 9 comparisons comparison NNS cord-005453-4057qib7 7050 10 with with IN cord-005453-4057qib7 7050 11 other other JJ cord-005453-4057qib7 7050 12 forms form NNS cord-005453-4057qib7 7050 13 of of IN cord-005453-4057qib7 7050 14 treatment treatment NN cord-005453-4057qib7 7050 15 are be VBP cord-005453-4057qib7 7050 16 required require VBN cord-005453-4057qib7 7050 17 . . . cord-005453-4057qib7 7051 1 Background background NN cord-005453-4057qib7 7051 2 : : : cord-005453-4057qib7 7052 1 BMT BMT NNP cord-005453-4057qib7 7052 2 is be VBZ cord-005453-4057qib7 7052 3 a a DT cord-005453-4057qib7 7052 4 well well RB cord-005453-4057qib7 7052 5 - - HYPH cord-005453-4057qib7 7052 6 established establish VBN cord-005453-4057qib7 7052 7 treatment treatment NN cord-005453-4057qib7 7052 8 modality modality NN cord-005453-4057qib7 7052 9 for for IN cord-005453-4057qib7 7052 10 haemoglobinopathies haemoglobinopathy NNS cord-005453-4057qib7 7052 11 , , , cord-005453-4057qib7 7052 12 limited limit VBN cord-005453-4057qib7 7052 13 by by IN cord-005453-4057qib7 7052 14 the the DT cord-005453-4057qib7 7052 15 availability availability NN cord-005453-4057qib7 7052 16 of of IN cord-005453-4057qib7 7052 17 related related JJ cord-005453-4057qib7 7052 18 donors donor NNS cord-005453-4057qib7 7052 19 . . . cord-005453-4057qib7 7053 1 Unrelated unrelated JJ cord-005453-4057qib7 7053 2 transplantation transplantation NN cord-005453-4057qib7 7053 3 has have VBZ cord-005453-4057qib7 7053 4 historically historically RB cord-005453-4057qib7 7053 5 shown show VBN cord-005453-4057qib7 7053 6 variable variable JJ cord-005453-4057qib7 7053 7 outcomes outcome NNS cord-005453-4057qib7 7053 8 driven drive VBN cord-005453-4057qib7 7053 9 by by IN cord-005453-4057qib7 7053 10 GvHD gvhd NN cord-005453-4057qib7 7053 11 and and CC cord-005453-4057qib7 7053 12 toxicity toxicity NN cord-005453-4057qib7 7053 13 , , , cord-005453-4057qib7 7053 14 and and CC cord-005453-4057qib7 7053 15 usually usually RB cord-005453-4057qib7 7053 16 restricted restrict VBN cord-005453-4057qib7 7053 17 to to IN cord-005453-4057qib7 7053 18 10/10 10/10 CD cord-005453-4057qib7 7053 19 matches match NNS cord-005453-4057qib7 7053 20 , , , cord-005453-4057qib7 7053 21 but but CC cord-005453-4057qib7 7053 22 the the DT cord-005453-4057qib7 7053 23 impact impact NN cord-005453-4057qib7 7053 24 of of IN cord-005453-4057qib7 7053 25 reduced reduce VBN cord-005453-4057qib7 7053 26 toxicity toxicity NN cord-005453-4057qib7 7053 27 conditioning conditioning NN cord-005453-4057qib7 7053 28 regimens regimen NNS cord-005453-4057qib7 7053 29 is be VBZ cord-005453-4057qib7 7053 30 yet yet RB cord-005453-4057qib7 7053 31 to to TO cord-005453-4057qib7 7053 32 be be VB cord-005453-4057qib7 7053 33 known know VBN cord-005453-4057qib7 7053 34 . . . cord-005453-4057qib7 7054 1 Methods method NNS cord-005453-4057qib7 7054 2 : : : cord-005453-4057qib7 7055 1 From from IN cord-005453-4057qib7 7055 2 2011 2011 CD cord-005453-4057qib7 7055 3 to to IN cord-005453-4057qib7 7055 4 2018 2018 CD cord-005453-4057qib7 7055 5 twenty twenty CD cord-005453-4057qib7 7055 6 - - HYPH cord-005453-4057qib7 7055 7 five five CD cord-005453-4057qib7 7055 8 consecutive consecutive JJ cord-005453-4057qib7 7055 9 unrelated unrelated JJ cord-005453-4057qib7 7055 10 bone bone NN cord-005453-4057qib7 7055 11 marrow marrow NN cord-005453-4057qib7 7055 12 transplants transplant NNS cord-005453-4057qib7 7055 13 were be VBD cord-005453-4057qib7 7055 14 conditioned condition VBN cord-005453-4057qib7 7055 15 with with IN cord-005453-4057qib7 7055 16 fludarabine fludarabine NN cord-005453-4057qib7 7055 17 160 160 CD cord-005453-4057qib7 7055 18 mg mg NNP cord-005453-4057qib7 7055 19 / / SYM cord-005453-4057qib7 7055 20 m m NNP cord-005453-4057qib7 7055 21 2 2 CD cord-005453-4057qib7 7055 22 , , , cord-005453-4057qib7 7055 23 treosulfan treosulfan NN cord-005453-4057qib7 7055 24 42 42 CD cord-005453-4057qib7 7055 25 g g NN cord-005453-4057qib7 7055 26 / / SYM cord-005453-4057qib7 7055 27 m m NNP cord-005453-4057qib7 7055 28 2 2 CD cord-005453-4057qib7 7055 29 , , , cord-005453-4057qib7 7055 30 thiotepa thiotepa VBZ cord-005453-4057qib7 7055 31 10 10 CD cord-005453-4057qib7 7055 32 mg/ mg/ NN cord-005453-4057qib7 7055 33 kg kg NNP cord-005453-4057qib7 7055 34 and and CC cord-005453-4057qib7 7055 35 ATG ATG NNP cord-005453-4057qib7 7055 36 ( ( -LRB- cord-005453-4057qib7 7055 37 Thymoglobulin Thymoglobulin NNP cord-005453-4057qib7 7055 38 ) ) -RRB- cord-005453-4057qib7 7056 1 11.25 11.25 CD cord-005453-4057qib7 7056 2 mg mg NNP cord-005453-4057qib7 7056 3 / / SYM cord-005453-4057qib7 7056 4 kg kg NNP cord-005453-4057qib7 7057 1 if if IN cord-005453-4057qib7 7057 2 the the DT cord-005453-4057qib7 7057 3 source source NN cord-005453-4057qib7 7057 4 of of IN cord-005453-4057qib7 7057 5 stem stem NN cord-005453-4057qib7 7057 6 cells cell NNS cord-005453-4057qib7 7057 7 was be VBD cord-005453-4057qib7 7057 8 marrow marrow NN cord-005453-4057qib7 7057 9 ( ( -LRB- cord-005453-4057qib7 7057 10 n n NN cord-005453-4057qib7 7057 11 = = SYM cord-005453-4057qib7 7057 12 21 21 CD cord-005453-4057qib7 7057 13 ) ) -RRB- cord-005453-4057qib7 7057 14 or or CC cord-005453-4057qib7 7057 15 PTCy PTCy NNS cord-005453-4057qib7 7057 16 if if IN cord-005453-4057qib7 7057 17 PBSC PBSC NNP cord-005453-4057qib7 7057 18 ( ( -LRB- cord-005453-4057qib7 7057 19 n n NN cord-005453-4057qib7 7057 20 = = SYM cord-005453-4057qib7 7057 21 4 4 CD cord-005453-4057qib7 7057 22 ) ) -RRB- cord-005453-4057qib7 7057 23 . . . cord-005453-4057qib7 7058 1 Endogenous endogenous JJ cord-005453-4057qib7 7058 2 haemopoiesis haemopoiesis NN cord-005453-4057qib7 7058 3 was be VBD cord-005453-4057qib7 7058 4 suppressed suppress VBN cord-005453-4057qib7 7058 5 pretransplantation pretransplantation NN cord-005453-4057qib7 7058 6 for for IN cord-005453-4057qib7 7058 7 a a DT cord-005453-4057qib7 7058 8 minimum minimum NN cord-005453-4057qib7 7058 9 of of IN cord-005453-4057qib7 7058 10 8 8 CD cord-005453-4057qib7 7058 11 weeks week NNS cord-005453-4057qib7 7058 12 . . . cord-005453-4057qib7 7059 1 GvHD GvHD NNP cord-005453-4057qib7 7059 2 prophylaxis prophylaxis NN cord-005453-4057qib7 7059 3 was be VBD cord-005453-4057qib7 7059 4 provided provide VBN cord-005453-4057qib7 7059 5 with with IN cord-005453-4057qib7 7059 6 ciclosporin ciclosporin NN cord-005453-4057qib7 7059 7 / / SYM cord-005453-4057qib7 7059 8 sirolimus sirolimus NN cord-005453-4057qib7 7059 9 and and CC cord-005453-4057qib7 7059 10 MMF mmf NN cord-005453-4057qib7 7059 11 . . . cord-005453-4057qib7 7060 1 Thirteen thirteen CD cord-005453-4057qib7 7060 2 patients patient NNS cord-005453-4057qib7 7060 3 were be VBD cord-005453-4057qib7 7060 4 transplanted transplant VBN cord-005453-4057qib7 7060 5 for for IN cord-005453-4057qib7 7060 6 b b NNP cord-005453-4057qib7 7060 7 thalassaemia thalassaemia NNP cord-005453-4057qib7 7060 8 major major NNP cord-005453-4057qib7 7060 9 , , , cord-005453-4057qib7 7060 10 one one CD cord-005453-4057qib7 7060 11 of of IN cord-005453-4057qib7 7060 12 a a DT cord-005453-4057qib7 7060 13 thalassaemia thalassaemia NN cord-005453-4057qib7 7060 14 major major NN cord-005453-4057qib7 7060 15 and and CC cord-005453-4057qib7 7060 16 11 11 CD cord-005453-4057qib7 7060 17 sickle sickle NN cord-005453-4057qib7 7060 18 cell cell NN cord-005453-4057qib7 7060 19 disease disease NN cord-005453-4057qib7 7060 20 . . . cord-005453-4057qib7 7061 1 The the DT cord-005453-4057qib7 7061 2 median median JJ cord-005453-4057qib7 7061 3 age age NN cord-005453-4057qib7 7061 4 was be VBD cord-005453-4057qib7 7061 5 8 8 CD cord-005453-4057qib7 7061 6 years year NNS cord-005453-4057qib7 7061 7 ( ( -LRB- cord-005453-4057qib7 7061 8 2 2 CD cord-005453-4057qib7 7061 9 -19 -19 CD cord-005453-4057qib7 7061 10 ) ) -RRB- cord-005453-4057qib7 7061 11 . . . cord-005453-4057qib7 7062 1 Ten ten CD cord-005453-4057qib7 7062 2 patients patient NNS cord-005453-4057qib7 7062 3 were be VBD cord-005453-4057qib7 7062 4 10/10 10/10 CD cord-005453-4057qib7 7062 5 matched match VBN cord-005453-4057qib7 7062 6 ( ( -LRB- cord-005453-4057qib7 7062 7 7 7 CD cord-005453-4057qib7 7062 8 thalassemia thalassemia NN cord-005453-4057qib7 7062 9 and and CC cord-005453-4057qib7 7062 10 3 3 CD cord-005453-4057qib7 7062 11 sickle sickle NN cord-005453-4057qib7 7062 12 ) ) -RRB- cord-005453-4057qib7 7062 13 and and CC cord-005453-4057qib7 7062 14 15 15 CD cord-005453-4057qib7 7062 15 patients patient NNS cord-005453-4057qib7 7062 16 had have VBD cord-005453-4057qib7 7062 17 a a DT cord-005453-4057qib7 7062 18 9/10 9/10 CD cord-005453-4057qib7 7062 19 match match NN cord-005453-4057qib7 7062 20 ( ( -LRB- cord-005453-4057qib7 7062 21 7 7 CD cord-005453-4057qib7 7062 22 thalassaemia thalassaemia NN cord-005453-4057qib7 7062 23 and and CC cord-005453-4057qib7 7062 24 8 8 CD cord-005453-4057qib7 7062 25 sickle sickle NN cord-005453-4057qib7 7062 26 ) ) -RRB- cord-005453-4057qib7 7062 27 . . . cord-005453-4057qib7 7063 1 The the DT cord-005453-4057qib7 7063 2 median median JJ cord-005453-4057qib7 7063 3 cell cell NN cord-005453-4057qib7 7063 4 dose dose NN cord-005453-4057qib7 7063 5 was be VBD cord-005453-4057qib7 7063 6 3.88 3.88 CD cord-005453-4057qib7 7063 7 x x SYM cord-005453-4057qib7 7063 8 10 10 CD cord-005453-4057qib7 7063 9 8 8 CD cord-005453-4057qib7 7063 10 TNC TNC NNP cord-005453-4057qib7 7063 11 / / SYM cord-005453-4057qib7 7063 12 kg kg NN cord-005453-4057qib7 7064 1 ( ( -LRB- cord-005453-4057qib7 7064 2 range range VBP cord-005453-4057qib7 7064 3 1.38 1.38 CD cord-005453-4057qib7 7064 4 -13.3 -13.3 CD cord-005453-4057qib7 7064 5 ) ) -RRB- cord-005453-4057qib7 7064 6 and and CC cord-005453-4057qib7 7065 1 5.22 5.22 CD cord-005453-4057qib7 7065 2 x x SYM cord-005453-4057qib7 7065 3 10 10 CD cord-005453-4057qib7 7065 4 6 6 CD cord-005453-4057qib7 7065 5 CD34+/kg CD34+/kg NNP cord-005453-4057qib7 7065 6 ( ( -LRB- cord-005453-4057qib7 7065 7 range range NN cord-005453-4057qib7 7065 8 1.10 1.10 CD cord-005453-4057qib7 7065 9 -27.41 -27.41 NN cord-005453-4057qib7 7065 10 ) ) -RRB- cord-005453-4057qib7 7065 11 . . . cord-005453-4057qib7 7066 1 The the DT cord-005453-4057qib7 7066 2 median median JJ cord-005453-4057qib7 7066 3 survival survival NN cord-005453-4057qib7 7066 4 was be VBD cord-005453-4057qib7 7066 5 13.4 13.4 CD cord-005453-4057qib7 7066 6 months month NNS cord-005453-4057qib7 7066 7 ( ( -LRB- cord-005453-4057qib7 7066 8 0.7 0.7 CD cord-005453-4057qib7 7066 9 -68.3 -68.3 NNP cord-005453-4057qib7 7066 10 ) ) -RRB- cord-005453-4057qib7 7066 11 . . . cord-005453-4057qib7 7067 1 Patients patient NNS cord-005453-4057qib7 7067 2 with with IN cord-005453-4057qib7 7067 3 thalassaemia thalassaemia NN cord-005453-4057qib7 7067 4 were be VBD cord-005453-4057qib7 7067 5 Pesaro Pesaro NNP cord-005453-4057qib7 7067 6 class class NN cord-005453-4057qib7 7067 7 I i NN cord-005453-4057qib7 7067 8 or or CC cord-005453-4057qib7 7067 9 II II NNP cord-005453-4057qib7 7067 10 ( ( -LRB- cord-005453-4057qib7 7067 11 Pesaro Pesaro NNP cord-005453-4057qib7 7067 12 class class NN cord-005453-4057qib7 7067 13 III iii CD cord-005453-4057qib7 7067 14 patients patient NNS cord-005453-4057qib7 7067 15 were be VBD cord-005453-4057qib7 7067 16 intensively intensively RB cord-005453-4057qib7 7067 17 chelated chelated JJ cord-005453-4057qib7 7067 18 pretransplantation pretransplantation NN cord-005453-4057qib7 7067 19 to to TO cord-005453-4057qib7 7067 20 return return VB cord-005453-4057qib7 7067 21 to to IN cord-005453-4057qib7 7067 22 class class NN cord-005453-4057qib7 7067 23 I i NN cord-005453-4057qib7 7067 24 or or CC cord-005453-4057qib7 7067 25 II II NNP cord-005453-4057qib7 7067 26 ) ) -RRB- cord-005453-4057qib7 7067 27 . . . cord-005453-4057qib7 7068 1 Patients patient NNS cord-005453-4057qib7 7068 2 with with IN cord-005453-4057qib7 7068 3 sickle sickle NN cord-005453-4057qib7 7068 4 cell cell NN cord-005453-4057qib7 7068 5 disease disease NN cord-005453-4057qib7 7068 6 were be VBD cord-005453-4057qib7 7068 7 transplanted transplant VBN cord-005453-4057qib7 7068 8 for for IN cord-005453-4057qib7 7068 9 stroke stroke NN cord-005453-4057qib7 7068 10 or or CC cord-005453-4057qib7 7068 11 recurrent recurrent JJ cord-005453-4057qib7 7068 12 vaso vaso JJ cord-005453-4057qib7 7068 13 - - HYPH cord-005453-4057qib7 7068 14 oclusive oclusive JJ cord-005453-4057qib7 7068 15 crises crisis NNS cord-005453-4057qib7 7068 16 and/or and/or CC cord-005453-4057qib7 7068 17 acute acute JJ cord-005453-4057qib7 7068 18 chest chest NN cord-005453-4057qib7 7068 19 syndrome syndrome NN cord-005453-4057qib7 7068 20 not not RB cord-005453-4057qib7 7068 21 responding respond VBG cord-005453-4057qib7 7068 22 to to IN cord-005453-4057qib7 7068 23 hydroxycarbamide hydroxycarbamide VB cord-005453-4057qib7 7068 24 . . . cord-005453-4057qib7 7069 1 Results result NNS cord-005453-4057qib7 7069 2 : : : cord-005453-4057qib7 7070 1 All all DT cord-005453-4057qib7 7070 2 patients patient NNS cord-005453-4057qib7 7070 3 engrafted engraft VBD cord-005453-4057qib7 7070 4 and and CC cord-005453-4057qib7 7070 5 achieved achieve VBD cord-005453-4057qib7 7070 6 evidence evidence NN cord-005453-4057qib7 7070 7 of of IN cord-005453-4057qib7 7070 8 donor donor NN cord-005453-4057qib7 7070 9 haemopoiesis haemopoiesis NN cord-005453-4057qib7 7070 10 on on IN cord-005453-4057qib7 7070 11 day day NN cord-005453-4057qib7 7070 12 +28 +28 CD cord-005453-4057qib7 7070 13 and and CC cord-005453-4057qib7 7070 14 achieved achieve VBD cord-005453-4057qib7 7070 15 transfusionindependence transfusionindependence NNP cord-005453-4057qib7 7070 16 and and CC cord-005453-4057qib7 7070 17 donor donor NN cord-005453-4057qib7 7070 18 haematological haematological JJ cord-005453-4057qib7 7070 19 values value NNS cord-005453-4057qib7 7070 20 , , , cord-005453-4057qib7 7070 21 but but CC cord-005453-4057qib7 7070 22 subsequently subsequently RB cord-005453-4057qib7 7070 23 one one CD cord-005453-4057qib7 7070 24 9/10 9/10 CD cord-005453-4057qib7 7070 25 patient patient NN cord-005453-4057qib7 7070 26 with with IN cord-005453-4057qib7 7070 27 thalassaemia thalassaemia NN cord-005453-4057qib7 7070 28 suffered suffer VBD cord-005453-4057qib7 7070 29 secondary secondary JJ cord-005453-4057qib7 7070 30 graft graft NN cord-005453-4057qib7 7070 31 failure failure NN cord-005453-4057qib7 7070 32 on on IN cord-005453-4057qib7 7070 33 day day NN cord-005453-4057qib7 7070 34 +75 +75 CD cord-005453-4057qib7 7070 35 after after IN cord-005453-4057qib7 7070 36 macrophage macrophage NN cord-005453-4057qib7 7070 37 activation activation NN cord-005453-4057qib7 7070 38 syndrome syndrome NN cord-005453-4057qib7 7070 39 . . . cord-005453-4057qib7 7071 1 Median median JJ cord-005453-4057qib7 7071 2 neutrophil neutrophil NN cord-005453-4057qib7 7071 3 engraftment engraftment NN cord-005453-4057qib7 7071 4 was be VBD cord-005453-4057qib7 7071 5 13 13 CD cord-005453-4057qib7 7071 6 days day NNS cord-005453-4057qib7 7071 7 ( ( -LRB- cord-005453-4057qib7 7071 8 range range VBP cord-005453-4057qib7 7071 9 9 9 CD cord-005453-4057qib7 7071 10 to to IN cord-005453-4057qib7 7071 11 19 19 CD cord-005453-4057qib7 7071 12 ) ) -RRB- cord-005453-4057qib7 7071 13 and and CC cord-005453-4057qib7 7071 14 12 12 CD cord-005453-4057qib7 7071 15 days day NNS cord-005453-4057qib7 7071 16 ( ( -LRB- cord-005453-4057qib7 7071 17 9 9 CD cord-005453-4057qib7 7071 18 -22 -22 CD cord-005453-4057qib7 7071 19 ) ) -RRB- cord-005453-4057qib7 7071 20 for for IN cord-005453-4057qib7 7071 21 10/10 10/10 CD cord-005453-4057qib7 7071 22 and and CC cord-005453-4057qib7 7071 23 9/ 9/ CD cord-005453-4057qib7 7071 24 10 10 CD cord-005453-4057qib7 7071 25 patients patient NNS cord-005453-4057qib7 7071 26 respectively respectively RB cord-005453-4057qib7 7071 27 . . . cord-005453-4057qib7 7072 1 Patient patient JJ cord-005453-4057qib7 7072 2 with with IN cord-005453-4057qib7 7072 3 sickle sickle NN cord-005453-4057qib7 7072 4 cell cell NN cord-005453-4057qib7 7072 5 disease disease NN cord-005453-4057qib7 7072 6 had have VBD cord-005453-4057qib7 7072 7 the the DT cord-005453-4057qib7 7072 8 platelet platelet NN cord-005453-4057qib7 7072 9 count count NN cord-005453-4057qib7 7072 10 maintained maintain VBD cord-005453-4057qib7 7073 1 > > XX cord-005453-4057qib7 7074 1 50 50 CD cord-005453-4057qib7 7074 2 x x SYM cord-005453-4057qib7 7074 3 10 10 CD cord-005453-4057qib7 7074 4 9 9 CD cord-005453-4057qib7 7074 5 /L /L . cord-005453-4057qib7 7074 6 at at RB cord-005453-4057qib7 7074 7 all all DT cord-005453-4057qib7 7074 8 times time NNS cord-005453-4057qib7 7074 9 . . . cord-005453-4057qib7 7075 1 The the DT cord-005453-4057qib7 7075 2 median median JJ cord-005453-4057qib7 7075 3 platelet platelet NN cord-005453-4057qib7 7075 4 engraftment engraftment NN cord-005453-4057qib7 7075 5 > > XX cord-005453-4057qib7 7076 1 50 50 CD cord-005453-4057qib7 7076 2 x x SYM cord-005453-4057qib7 7076 3 10 10 CD cord-005453-4057qib7 7076 4 9 9 CD cord-005453-4057qib7 7076 5 /L /L , cord-005453-4057qib7 7076 6 was be VBD cord-005453-4057qib7 7076 7 31 31 CD cord-005453-4057qib7 7076 8 days day NNS cord-005453-4057qib7 7076 9 ( ( -LRB- cord-005453-4057qib7 7076 10 range range VBP cord-005453-4057qib7 7076 11 21 21 CD cord-005453-4057qib7 7076 12 to to IN cord-005453-4057qib7 7076 13 53 53 CD cord-005453-4057qib7 7076 14 ) ) -RRB- cord-005453-4057qib7 7076 15 and and CC cord-005453-4057qib7 7076 16 40 40 CD cord-005453-4057qib7 7076 17 days day NNS cord-005453-4057qib7 7076 18 ( ( -LRB- cord-005453-4057qib7 7076 19 range range VB cord-005453-4057qib7 7076 20 15 15 CD cord-005453-4057qib7 7076 21 to to IN cord-005453-4057qib7 7076 22 86 86 CD cord-005453-4057qib7 7076 23 ) ) -RRB- cord-005453-4057qib7 7076 24 10/10 10/10 CD cord-005453-4057qib7 7076 25 and and CC cord-005453-4057qib7 7076 26 9/10 9/10 CD cord-005453-4057qib7 7076 27 patients patient NNS cord-005453-4057qib7 7076 28 respectively respectively RB cord-005453-4057qib7 7076 29 . . . cord-005453-4057qib7 7077 1 There there EX cord-005453-4057qib7 7077 2 were be VBD cord-005453-4057qib7 7077 3 three three CD cord-005453-4057qib7 7077 4 deaths death NNS cord-005453-4057qib7 7077 5 , , , cord-005453-4057qib7 7077 6 all all DT cord-005453-4057qib7 7077 7 in in IN cord-005453-4057qib7 7077 8 the the DT cord-005453-4057qib7 7077 9 9/10 9/10 CD cord-005453-4057qib7 7077 10 matched match VBN cord-005453-4057qib7 7077 11 group group NN cord-005453-4057qib7 7077 12 : : : cord-005453-4057qib7 7077 13 two two CD cord-005453-4057qib7 7077 14 with with IN cord-005453-4057qib7 7077 15 thalassaemia thalassaemia NN cord-005453-4057qib7 7077 16 ( ( -LRB- cord-005453-4057qib7 7077 17 day day NN cord-005453-4057qib7 7077 18 +257 +257 NNP cord-005453-4057qib7 7077 19 due due JJ cord-005453-4057qib7 7077 20 to to IN cord-005453-4057qib7 7077 21 idiopathic idiopathic JJ cord-005453-4057qib7 7077 22 pneumonia pneumonia NN cord-005453-4057qib7 7077 23 syndrome syndrome NN cord-005453-4057qib7 7077 24 and and CC cord-005453-4057qib7 7077 25 day day NN cord-005453-4057qib7 7077 26 +102 +102 NNS cord-005453-4057qib7 7077 27 due due JJ cord-005453-4057qib7 7077 28 to to IN cord-005453-4057qib7 7077 29 MAS MAS NNP cord-005453-4057qib7 7077 30 ) ) -RRB- cord-005453-4057qib7 7077 31 and and CC cord-005453-4057qib7 7077 32 one one CD cord-005453-4057qib7 7077 33 with with IN cord-005453-4057qib7 7077 34 SCD SCD NNP cord-005453-4057qib7 7077 35 ( ( -LRB- cord-005453-4057qib7 7077 36 day day NN cord-005453-4057qib7 7077 37 +43 +43 CD cord-005453-4057qib7 7077 38 due due IN cord-005453-4057qib7 7077 39 to to IN cord-005453-4057qib7 7077 40 IPS IPS NNP cord-005453-4057qib7 7077 41 ) ) -RRB- cord-005453-4057qib7 7077 42 . . . cord-005453-4057qib7 7078 1 There there EX cord-005453-4057qib7 7078 2 were be VBD cord-005453-4057qib7 7078 3 different different JJ cord-005453-4057qib7 7078 4 trends trend NNS cord-005453-4057qib7 7078 5 of of IN cord-005453-4057qib7 7078 6 complications complication NNS cord-005453-4057qib7 7078 7 seen see VBN cord-005453-4057qib7 7078 8 by by IN cord-005453-4057qib7 7078 9 degree degree NN cord-005453-4057qib7 7078 10 of of IN cord-005453-4057qib7 7078 11 matching matching NN cord-005453-4057qib7 7078 12 that that WDT cord-005453-4057qib7 7078 13 did do VBD cord-005453-4057qib7 7078 14 not not RB cord-005453-4057qib7 7078 15 segregate segregate VB cord-005453-4057qib7 7078 16 otherwise otherwise RB cord-005453-4057qib7 7078 17 by by IN cord-005453-4057qib7 7078 18 disease disease NN cord-005453-4057qib7 7078 19 . . . cord-005453-4057qib7 7079 1 Conclusions conclusion NNS cord-005453-4057qib7 7079 2 : : : cord-005453-4057qib7 7080 1 In in IN cord-005453-4057qib7 7080 2 conclusion conclusion NN cord-005453-4057qib7 7080 3 , , , cord-005453-4057qib7 7080 4 unrelated unrelated JJ cord-005453-4057qib7 7080 5 BMT BMT NNP cord-005453-4057qib7 7080 6 for for IN cord-005453-4057qib7 7080 7 haemoglobinopathies haemoglobinopathy NNS cord-005453-4057qib7 7080 8 with with IN cord-005453-4057qib7 7080 9 reduced reduce VBN cord-005453-4057qib7 7080 10 toxicity toxicity NN cord-005453-4057qib7 7080 11 regimens regimen NNS cord-005453-4057qib7 7080 12 is be VBZ cord-005453-4057qib7 7080 13 feasible feasible JJ cord-005453-4057qib7 7080 14 . . . cord-005453-4057qib7 7081 1 Whilst whilst IN cord-005453-4057qib7 7081 2 GvHD GvHD NNP cord-005453-4057qib7 7081 3 caused cause VBD cord-005453-4057qib7 7081 4 significant significant JJ cord-005453-4057qib7 7081 5 morbidity morbidity NN cord-005453-4057qib7 7081 6 during during IN cord-005453-4057qib7 7081 7 the the DT cord-005453-4057qib7 7081 8 transplant transplant NN cord-005453-4057qib7 7081 9 period period NN cord-005453-4057qib7 7081 10 , , , cord-005453-4057qib7 7081 11 other other JJ cord-005453-4057qib7 7081 12 alloreactive alloreactive JJ cord-005453-4057qib7 7081 13 / / SYM cord-005453-4057qib7 7081 14 endothelial endothelial JJ cord-005453-4057qib7 7081 15 complications complication NNS cord-005453-4057qib7 7081 16 ( ( -LRB- cord-005453-4057qib7 7081 17 VOD VOD NNP cord-005453-4057qib7 7081 18 , , , cord-005453-4057qib7 7081 19 macrophage macrophage NN cord-005453-4057qib7 7081 20 activation activation NN cord-005453-4057qib7 7081 21 syndrome syndrome NN cord-005453-4057qib7 7081 22 , , , cord-005453-4057qib7 7081 23 idiopathic idiopathic JJ cord-005453-4057qib7 7081 24 pneumonia pneumonia NN cord-005453-4057qib7 7081 25 syndrome syndrome NN cord-005453-4057qib7 7081 26 ) ) -RRB- cord-005453-4057qib7 7081 27 were be VBD cord-005453-4057qib7 7081 28 only only RB cord-005453-4057qib7 7081 29 seen see VBN cord-005453-4057qib7 7081 30 in in IN cord-005453-4057qib7 7081 31 the the DT cord-005453-4057qib7 7081 32 9/10 9/10 CD cord-005453-4057qib7 7081 33 transplants transplant NNS cord-005453-4057qib7 7081 34 . . . cord-005453-4057qib7 7082 1 Disease disease NN cord-005453-4057qib7 7082 2 - - HYPH cord-005453-4057qib7 7082 3 free free JJ cord-005453-4057qib7 7082 4 survival survival NN cord-005453-4057qib7 7082 5 , , , cord-005453-4057qib7 7082 6 dependent dependent JJ cord-005453-4057qib7 7082 7 on on IN cord-005453-4057qib7 7082 8 transplantrelated transplantrelated JJ cord-005453-4057qib7 7082 9 mortality mortality NN cord-005453-4057qib7 7082 10 , , , cord-005453-4057qib7 7082 11 and and CC cord-005453-4057qib7 7082 12 lack lack NN cord-005453-4057qib7 7082 13 of of IN cord-005453-4057qib7 7082 14 long long JJ cord-005453-4057qib7 7082 15 - - HYPH cord-005453-4057qib7 7082 16 term term NN cord-005453-4057qib7 7082 17 toxicity toxicity NN cord-005453-4057qib7 7082 18 , , , cord-005453-4057qib7 7082 19 including include VBG cord-005453-4057qib7 7082 20 chronic chronic JJ cord-005453-4057qib7 7082 21 GvHD GvHD NNP cord-005453-4057qib7 7082 22 , , , cord-005453-4057qib7 7082 23 are be VBP cord-005453-4057qib7 7082 24 determined determine VBN cord-005453-4057qib7 7082 25 by by IN cord-005453-4057qib7 7082 26 the the DT cord-005453-4057qib7 7082 27 degree degree NN cord-005453-4057qib7 7082 28 of of IN cord-005453-4057qib7 7082 29 matching matching NN cord-005453-4057qib7 7082 30 . . . cord-005453-4057qib7 7083 1 10/10 10/10 CD cord-005453-4057qib7 7083 2 matched match VBN cord-005453-4057qib7 7083 3 transplants transplant NNS cord-005453-4057qib7 7083 4 have have VBP cord-005453-4057qib7 7083 5 excellent excellent JJ cord-005453-4057qib7 7083 6 long long JJ cord-005453-4057qib7 7083 7 - - HYPH cord-005453-4057qib7 7083 8 term term NN cord-005453-4057qib7 7083 9 outcomes outcome NNS cord-005453-4057qib7 7083 10 with with IN cord-005453-4057qib7 7083 11 no no DT cord-005453-4057qib7 7083 12 chronic chronic JJ cord-005453-4057qib7 7083 13 GvHD gvhd NN cord-005453-4057qib7 7083 14 > > NFP cord-005453-4057qib7 7083 15 18 18 CD cord-005453-4057qib7 7083 16 months month NNS cord-005453-4057qib7 7083 17 and and CC cord-005453-4057qib7 7083 18 can can MD cord-005453-4057qib7 7083 19 be be VB cord-005453-4057qib7 7083 20 considered consider VBN cord-005453-4057qib7 7083 21 for for IN cord-005453-4057qib7 7083 22 patients patient NNS cord-005453-4057qib7 7083 23 without without IN cord-005453-4057qib7 7083 24 a a DT cord-005453-4057qib7 7083 25 related related JJ cord-005453-4057qib7 7083 26 donor donor NN cord-005453-4057qib7 7083 27 ; ; : cord-005453-4057qib7 7083 28 whereas whereas IN cord-005453-4057qib7 7083 29 9/ 9/ CD cord-005453-4057qib7 7083 30 10 10 CD cord-005453-4057qib7 7083 31 transplant transplant NN cord-005453-4057qib7 7083 32 have have VBP cord-005453-4057qib7 7083 33 significant significant JJ cord-005453-4057qib7 7083 34 toxicity toxicity NN cord-005453-4057qib7 7083 35 and and CC cord-005453-4057qib7 7083 36 mortality mortality NN cord-005453-4057qib7 7083 37 , , , cord-005453-4057qib7 7083 38 warranting warrant VBG cord-005453-4057qib7 7083 39 a a DT cord-005453-4057qib7 7083 40 haploidentical haploidentical JJ cord-005453-4057qib7 7083 41 approach approach NN cord-005453-4057qib7 7083 42 . . . cord-005453-4057qib7 7084 1 Disclosure disclosure NN cord-005453-4057qib7 7084 2 : : : cord-005453-4057qib7 7084 3 No no DT cord-005453-4057qib7 7084 4 conflict conflict NN cord-005453-4057qib7 7084 5 . . . cord-005453-4057qib7 7085 1 Long long JJ cord-005453-4057qib7 7085 2 - - HYPH cord-005453-4057qib7 7085 3 term term NN cord-005453-4057qib7 7085 4 safety safety NN cord-005453-4057qib7 7085 5 and and CC cord-005453-4057qib7 7085 6 efficacy efficacy NN cord-005453-4057qib7 7085 7 of of IN cord-005453-4057qib7 7085 8 lentiglobin lentiglobin NNP cord-005453-4057qib7 7085 9 gene gene NNP cord-005453-4057qib7 7085 10 therapy therapy NN cord-005453-4057qib7 7085 11 in in IN cord-005453-4057qib7 7085 12 patients patient NNS cord-005453-4057qib7 7085 13 with with IN cord-005453-4057qib7 7085 14 transfusion transfusion NN cord-005453-4057qib7 7085 15 - - HYPH cord-005453-4057qib7 7085 16 dependent dependent JJ cord-005453-4057qib7 7085 17 β β NN cord-005453-4057qib7 7085 18 - - HYPH cord-005453-4057qib7 7085 19 thalassemia thalassemia NN cord-005453-4057qib7 7085 20 following follow VBG cord-005453-4057qib7 7085 21 completion completion NN cord-005453-4057qib7 7085 22 of of IN cord-005453-4057qib7 7085 23 the the DT cord-005453-4057qib7 7085 24 phase phase NN cord-005453-4057qib7 7085 25 1/2 1/2 CD cord-005453-4057qib7 7085 26 northstar northstar NNP cord-005453-4057qib7 7085 27 study study NN cord-005453-4057qib7 7085 28 _SP cord-005453-4057qib7 7085 29 Patients Patients NNP cord-005453-4057qib7 7085 30 with with IN cord-005453-4057qib7 7085 31 transfusion transfusion NN cord-005453-4057qib7 7085 32 - - HYPH cord-005453-4057qib7 7085 33 dependent dependent JJ cord-005453-4057qib7 7085 34 β β NN cord-005453-4057qib7 7085 35 - - HYPH cord-005453-4057qib7 7085 36 thalassemia thalassemia NN cord-005453-4057qib7 7085 37 ( ( -LRB- cord-005453-4057qib7 7085 38 TDT TDT NNP cord-005453-4057qib7 7085 39 ) ) -RRB- cord-005453-4057qib7 7085 40 may may MD cord-005453-4057qib7 7085 41 benefit benefit VB cord-005453-4057qib7 7085 42 from from IN cord-005453-4057qib7 7085 43 gene gene NN cord-005453-4057qib7 7085 44 therapy therapy NN cord-005453-4057qib7 7085 45 involving involve VBG cord-005453-4057qib7 7085 46 β β NNP cord-005453-4057qib7 7085 47 - - HYPH cord-005453-4057qib7 7085 48 globin globin NN cord-005453-4057qib7 7085 49 gene gene NN cord-005453-4057qib7 7085 50 addition addition NN cord-005453-4057qib7 7085 51 to to IN cord-005453-4057qib7 7085 52 hematopoietic hematopoietic JJ cord-005453-4057qib7 7085 53 stem stem NN cord-005453-4057qib7 7085 54 cells cell NNS cord-005453-4057qib7 7085 55 ( ( -LRB- cord-005453-4057qib7 7085 56 HSCs hscs NN cord-005453-4057qib7 7085 57 ) ) -RRB- cord-005453-4057qib7 7085 58 enabling enable VBG cord-005453-4057qib7 7085 59 production production NN cord-005453-4057qib7 7085 60 of of IN cord-005453-4057qib7 7085 61 functional functional JJ cord-005453-4057qib7 7085 62 hemoglobin hemoglobin NN cord-005453-4057qib7 7085 63 ( ( -LRB- cord-005453-4057qib7 7085 64 Hb Hb NNP cord-005453-4057qib7 7085 65 ) ) -RRB- cord-005453-4057qib7 7085 66 . . . cord-005453-4057qib7 7086 1 LentiGlobin LentiGlobin NNP cord-005453-4057qib7 7086 2 gene gene NN cord-005453-4057qib7 7086 3 therapy therapy NN cord-005453-4057qib7 7086 4 contains contain VBZ cord-005453-4057qib7 7086 5 autologous autologous JJ cord-005453-4057qib7 7086 6 CD34 CD34 NNP cord-005453-4057qib7 7087 1 + + CC cord-005453-4057qib7 7087 2 HSCs hscs NN cord-005453-4057qib7 7087 3 transduced transduce VBD cord-005453-4057qib7 7087 4 ex ex NN cord-005453-4057qib7 7087 5 vivo vivo NN cord-005453-4057qib7 7087 6 with with IN cord-005453-4057qib7 7087 7 the the DT cord-005453-4057qib7 7087 8 BB305 BB305 NNP cord-005453-4057qib7 7087 9 lentiviral lentiviral NN cord-005453-4057qib7 7087 10 vector vector NN cord-005453-4057qib7 7087 11 encoding encode VBG cord-005453-4057qib7 7087 12 β β NN cord-005453-4057qib7 7087 13 - - HYPH cord-005453-4057qib7 7087 14 globin globin NN cord-005453-4057qib7 7087 15 with with IN cord-005453-4057qib7 7087 16 a a DT cord-005453-4057qib7 7087 17 T87Q t87q JJ cord-005453-4057qib7 7087 18 substitution substitution NN cord-005453-4057qib7 7087 19 under under IN cord-005453-4057qib7 7087 20 transcriptional transcriptional JJ cord-005453-4057qib7 7087 21 control control NN cord-005453-4057qib7 7087 22 of of IN cord-005453-4057qib7 7087 23 the the DT cord-005453-4057qib7 7087 24 encoding encoding NN cord-005453-4057qib7 7087 25 β β NN cord-005453-4057qib7 7087 26 - - HYPH cord-005453-4057qib7 7087 27 globin globin NN cord-005453-4057qib7 7087 28 locus locus NN cord-005453-4057qib7 7087 29 control control NN cord-005453-4057qib7 7087 30 region region NN cord-005453-4057qib7 7087 31 . . . cord-005453-4057qib7 7088 1 The the DT cord-005453-4057qib7 7088 2 safety safety NN cord-005453-4057qib7 7088 3 and and CC cord-005453-4057qib7 7088 4 efficacy efficacy NN cord-005453-4057qib7 7088 5 of of IN cord-005453-4057qib7 7088 6 LentiGlobin LentiGlobin NNP cord-005453-4057qib7 7088 7 was be VBD cord-005453-4057qib7 7088 8 evaluated evaluate VBN cord-005453-4057qib7 7088 9 in in IN cord-005453-4057qib7 7088 10 adults adult NNS cord-005453-4057qib7 7088 11 and and CC cord-005453-4057qib7 7088 12 adolescents adolescent NNS cord-005453-4057qib7 7088 13 with with IN cord-005453-4057qib7 7088 14 TDT TDT NNP cord-005453-4057qib7 7088 15 in in IN cord-005453-4057qib7 7088 16 the the DT cord-005453-4057qib7 7088 17 2-year 2-year CD cord-005453-4057qib7 7088 18 phase phase NN cord-005453-4057qib7 7088 19 1/2 1/2 CD cord-005453-4057qib7 7088 20 Northstar Northstar NNP cord-005453-4057qib7 7088 21 study study NN cord-005453-4057qib7 7088 22 ( ( -LRB- cord-005453-4057qib7 7088 23 HGB-204 HGB-204 NNP cord-005453-4057qib7 7088 24 ; ; : cord-005453-4057qib7 7088 25 NCT01745120 NCT01745120 NNP cord-005453-4057qib7 7088 26 ) ) -RRB- cord-005453-4057qib7 7088 27 . . . cord-005453-4057qib7 7089 1 Methods method NNS cord-005453-4057qib7 7089 2 : : : cord-005453-4057qib7 7090 1 Patients patient NNS cord-005453-4057qib7 7090 2 with with IN cord-005453-4057qib7 7090 3 TDT TDT NNP cord-005453-4057qib7 7090 4 ( ( -LRB- cord-005453-4057qib7 7090 5 ≥ ≥ NNP cord-005453-4057qib7 7090 6 100 100 CD cord-005453-4057qib7 7090 7 mL ml NN cord-005453-4057qib7 7090 8 / / SYM cord-005453-4057qib7 7090 9 kg kg NN cord-005453-4057qib7 7090 10 / / SYM cord-005453-4057qib7 7090 11 year year NN cord-005453-4057qib7 7090 12 of of IN cord-005453-4057qib7 7090 13 red red JJ cord-005453-4057qib7 7090 14 blood blood NN cord-005453-4057qib7 7090 15 cells cell NNS cord-005453-4057qib7 7090 16 [ [ -LRB- cord-005453-4057qib7 7090 17 RBCs rbc NNS cord-005453-4057qib7 7090 18 ] ] -RRB- cord-005453-4057qib7 7090 19 or or CC cord-005453-4057qib7 7090 20 ≥ ≥ CD cord-005453-4057qib7 7090 21 8 8 CD cord-005453-4057qib7 7090 22 RBC RBC NNP cord-005453-4057qib7 7090 23 transfusions transfusion NNS cord-005453-4057qib7 7090 24 / / SYM cord-005453-4057qib7 7090 25 year year NN cord-005453-4057qib7 7090 26 ) ) -RRB- cord-005453-4057qib7 7090 27 received receive VBD cord-005453-4057qib7 7090 28 G G NNP cord-005453-4057qib7 7090 29 - - HYPH cord-005453-4057qib7 7090 30 CSF csf NN cord-005453-4057qib7 7090 31 and and CC cord-005453-4057qib7 7090 32 plerixafor plerixafor NN cord-005453-4057qib7 7090 33 for for IN cord-005453-4057qib7 7090 34 HSC HSC NNP cord-005453-4057qib7 7090 35 mobilization mobilization NN cord-005453-4057qib7 7090 36 . . . cord-005453-4057qib7 7091 1 To to TO cord-005453-4057qib7 7091 2 generate generate VB cord-005453-4057qib7 7091 3 drug drug NN cord-005453-4057qib7 7091 4 product product NN cord-005453-4057qib7 7091 5 ( ( -LRB- cord-005453-4057qib7 7091 6 DP DP NNP cord-005453-4057qib7 7091 7 ) ) -RRB- cord-005453-4057qib7 7091 8 , , , cord-005453-4057qib7 7091 9 CD34 CD34 NNP cord-005453-4057qib7 7091 10 + + CC cord-005453-4057qib7 7091 11 HSCs hsc NNS cord-005453-4057qib7 7091 12 were be VBD cord-005453-4057qib7 7091 13 transduced transduce VBN cord-005453-4057qib7 7091 14 with with IN cord-005453-4057qib7 7091 15 the the DT cord-005453-4057qib7 7091 16 BB305 BB305 NNP cord-005453-4057qib7 7091 17 lentiviral lentiviral JJ cord-005453-4057qib7 7091 18 vector vector NN cord-005453-4057qib7 7091 19 . . . cord-005453-4057qib7 7092 1 Patients patient NNS cord-005453-4057qib7 7092 2 underwent undergo VBD cord-005453-4057qib7 7092 3 single single JJ cord-005453-4057qib7 7092 4 - - HYPH cord-005453-4057qib7 7092 5 agent agent NN cord-005453-4057qib7 7092 6 , , , cord-005453-4057qib7 7092 7 myeloablative myeloablative NNP cord-005453-4057qib7 7092 8 busulfan busulfan NNP cord-005453-4057qib7 7092 9 conditioning conditioning NN cord-005453-4057qib7 7092 10 , , , cord-005453-4057qib7 7092 11 were be VBD cord-005453-4057qib7 7092 12 infused infuse VBN cord-005453-4057qib7 7092 13 with with IN cord-005453-4057qib7 7092 14 the the DT cord-005453-4057qib7 7092 15 DP dp NN cord-005453-4057qib7 7092 16 , , , cord-005453-4057qib7 7092 17 and and CC cord-005453-4057qib7 7092 18 were be VBD cord-005453-4057qib7 7092 19 followed follow VBN cord-005453-4057qib7 7092 20 for for IN cord-005453-4057qib7 7092 21 safety safety NN cord-005453-4057qib7 7092 22 and and CC cord-005453-4057qib7 7092 23 efficacy efficacy NN cord-005453-4057qib7 7092 24 . . . cord-005453-4057qib7 7093 1 Results result NNS cord-005453-4057qib7 7093 2 : : : cord-005453-4057qib7 7094 1 Eighteen eighteen CD cord-005453-4057qib7 7094 2 patients patient NNS cord-005453-4057qib7 7094 3 have have VBP cord-005453-4057qib7 7094 4 been be VBN cord-005453-4057qib7 7094 5 treated treat VBN cord-005453-4057qib7 7094 6 in in IN cord-005453-4057qib7 7094 7 the the DT cord-005453-4057qib7 7094 8 completed complete VBN cord-005453-4057qib7 7094 9 Northstar Northstar NNP cord-005453-4057qib7 7094 10 study study NN cord-005453-4057qib7 7094 11 . . . cord-005453-4057qib7 7095 1 As as IN cord-005453-4057qib7 7095 2 of of IN cord-005453-4057qib7 7095 3 14 14 CD cord-005453-4057qib7 7095 4 September September NNP cord-005453-4057qib7 7095 5 2018 2018 CD cord-005453-4057qib7 7095 6 , , , cord-005453-4057qib7 7095 7 patients patient NNS cord-005453-4057qib7 7095 8 had have VBD cord-005453-4057qib7 7095 9 a a DT cord-005453-4057qib7 7095 10 median median JJ cord-005453-4057qib7 7095 11 follow follow NN cord-005453-4057qib7 7095 12 - - HYPH cord-005453-4057qib7 7095 13 up up NN cord-005453-4057qib7 7095 14 of of IN cord-005453-4057qib7 7095 15 38.9 38.9 CD cord-005453-4057qib7 7095 16 ( ( -LRB- cord-005453-4057qib7 7095 17 min min NN cord-005453-4057qib7 7095 18 -max -max ADD cord-005453-4057qib7 7095 19 : : : cord-005453-4057qib7 7096 1 29.3 29.3 CD cord-005453-4057qib7 7096 2 -48.1 -48.1 NNP cord-005453-4057qib7 7096 3 ) ) -RRB- cord-005453-4057qib7 7096 4 months month NNS cord-005453-4057qib7 7096 5 . . . cord-005453-4057qib7 7097 1 The the DT cord-005453-4057qib7 7097 2 median median JJ cord-005453-4057qib7 7097 3 age age NN cord-005453-4057qib7 7097 4 at at IN cord-005453-4057qib7 7097 5 consent consent NN cord-005453-4057qib7 7097 6 was be VBD cord-005453-4057qib7 7097 7 20 20 CD cord-005453-4057qib7 7097 8 ( ( -LRB- cord-005453-4057qib7 7097 9 min min NN cord-005453-4057qib7 7097 10 -max -max -RRB- cord-005453-4057qib7 7097 11 : : : cord-005453-4057qib7 7097 12 12 12 CD cord-005453-4057qib7 7097 13 -35 -35 CD cord-005453-4057qib7 7097 14 ) ) -RRB- cord-005453-4057qib7 7097 15 years year NNS cord-005453-4057qib7 7097 16 including include VBG cord-005453-4057qib7 7097 17 15 15 CD cord-005453-4057qib7 7097 18 patients patient NNS cord-005453-4057qib7 7097 19 ≥ ≥ CD cord-005453-4057qib7 7097 20 18 18 CD cord-005453-4057qib7 7097 21 years year NNS cord-005453-4057qib7 7097 22 old old JJ cord-005453-4057qib7 7097 23 . . . cord-005453-4057qib7 7098 1 Patients patient NNS cord-005453-4057qib7 7098 2 received receive VBD cord-005453-4057qib7 7098 3 a a DT cord-005453-4057qib7 7098 4 median median JJ cord-005453-4057qib7 7098 5 cell cell NN cord-005453-4057qib7 7098 6 dose dose NN cord-005453-4057qib7 7098 7 of of IN cord-005453-4057qib7 7098 8 8.1 8.1 CD cord-005453-4057qib7 7098 9 ( ( -LRB- cord-005453-4057qib7 7098 10 min min NN cord-005453-4057qib7 7098 11 -max -max ADD cord-005453-4057qib7 7098 12 : : : cord-005453-4057qib7 7099 1 5.2 5.2 CD cord-005453-4057qib7 7099 2 -18.1 -18.1 CD cord-005453-4057qib7 7099 3 ) ) -RRB- cord-005453-4057qib7 7100 1 CD34 CD34 NNP cord-005453-4057qib7 7100 2 + + CC cord-005453-4057qib7 7100 3 cells cell NNS cord-005453-4057qib7 7100 4 x10 x10 CD cord-005453-4057qib7 7100 5 6 6 CD cord-005453-4057qib7 7101 1 /kg /kg NFP cord-005453-4057qib7 7101 2 with with IN cord-005453-4057qib7 7101 3 a a DT cord-005453-4057qib7 7101 4 median median JJ cord-005453-4057qib7 7101 5 DP dp NN cord-005453-4057qib7 7101 6 vector vector NN cord-005453-4057qib7 7101 7 copy copy NN cord-005453-4057qib7 7101 8 number number NN cord-005453-4057qib7 7101 9 ( ( -LRB- cord-005453-4057qib7 7101 10 VCN VCN NNP cord-005453-4057qib7 7101 11 ) ) -RRB- cord-005453-4057qib7 7101 12 of of IN cord-005453-4057qib7 7101 13 0.7 0.7 CD cord-005453-4057qib7 7101 14 ( ( -LRB- cord-005453-4057qib7 7101 15 min min NN cord-005453-4057qib7 7101 16 -max -max -RRB- cord-005453-4057qib7 7101 17 : : : cord-005453-4057qib7 7101 18 0.3 0.3 CD cord-005453-4057qib7 7101 19 -1.5 -1.5 NFP cord-005453-4057qib7 7101 20 ) ) -RRB- cord-005453-4057qib7 7101 21 vector vector NN cord-005453-4057qib7 7101 22 copies/ copies/ NN cord-005453-4057qib7 7101 23 diploid diploid JJ cord-005453-4057qib7 7101 24 genome genome NN cord-005453-4057qib7 7101 25 . . . cord-005453-4057qib7 7102 1 The the DT cord-005453-4057qib7 7102 2 median median JJ cord-005453-4057qib7 7102 3 liver liver NN cord-005453-4057qib7 7102 4 iron iron NN cord-005453-4057qib7 7102 5 content content NN cord-005453-4057qib7 7102 6 ( ( -LRB- cord-005453-4057qib7 7102 7 LIC LIC NNP cord-005453-4057qib7 7102 8 ) ) -RRB- cord-005453-4057qib7 7102 9 at at IN cord-005453-4057qib7 7102 10 baseline baseline NN cord-005453-4057qib7 7102 11 was be VBD cord-005453-4057qib7 7102 12 5.7 5.7 CD cord-005453-4057qib7 7102 13 ( ( -LRB- cord-005453-4057qib7 7102 14 min min NN cord-005453-4057qib7 7102 15 -max -max -RRB- cord-005453-4057qib7 7102 16 : : : cord-005453-4057qib7 7102 17 0.4 0.4 CD cord-005453-4057qib7 7102 18 -26.4 -26.4 CD cord-005453-4057qib7 7102 19 ) ) -RRB- cord-005453-4057qib7 7103 1 mg mg NNP cord-005453-4057qib7 7104 1 Fe Fe NNP cord-005453-4057qib7 7104 2 / / SYM cord-005453-4057qib7 7104 3 g g NN cord-005453-4057qib7 7104 4 dw dw NNP cord-005453-4057qib7 7104 5 . . . cord-005453-4057qib7 7105 1 Outcomes outcome NNS cord-005453-4057qib7 7105 2 by by IN cord-005453-4057qib7 7105 3 age age NN cord-005453-4057qib7 7105 4 and and CC cord-005453-4057qib7 7105 5 baseline baseline JJ cord-005453-4057qib7 7105 6 iron iron NN cord-005453-4057qib7 7105 7 status status NN cord-005453-4057qib7 7105 8 will will MD cord-005453-4057qib7 7105 9 be be VB cord-005453-4057qib7 7105 10 presented present VBN cord-005453-4057qib7 7105 11 . . . cord-005453-4057qib7 7106 1 The the DT cord-005453-4057qib7 7106 2 median median JJ cord-005453-4057qib7 7106 3 time time NN cord-005453-4057qib7 7106 4 to to IN cord-005453-4057qib7 7106 5 neutrophil neutrophil NN cord-005453-4057qib7 7106 6 and and CC cord-005453-4057qib7 7106 7 platelet platelet NN cord-005453-4057qib7 7106 8 engraftment engraftment NN cord-005453-4057qib7 7106 9 was be VBD cord-005453-4057qib7 7106 10 18.5 18.5 CD cord-005453-4057qib7 7106 11 ( ( -LRB- cord-005453-4057qib7 7106 12 min min NN cord-005453-4057qib7 7106 13 -max -max -RRB- cord-005453-4057qib7 7106 14 : : : cord-005453-4057qib7 7106 15 14 14 CD cord-005453-4057qib7 7106 16 -30 -30 CD cord-005453-4057qib7 7106 17 ) ) -RRB- cord-005453-4057qib7 7106 18 and and CC cord-005453-4057qib7 7106 19 39.5 39.5 CD cord-005453-4057qib7 7106 20 ( ( -LRB- cord-005453-4057qib7 7106 21 min min NN cord-005453-4057qib7 7106 22 -max -max -RRB- cord-005453-4057qib7 7106 23 : : : cord-005453-4057qib7 7106 24 19 19 CD cord-005453-4057qib7 7106 25 -191 -191 NN cord-005453-4057qib7 7106 26 ) ) -RRB- cord-005453-4057qib7 7106 27 days day NNS cord-005453-4057qib7 7106 28 , , , cord-005453-4057qib7 7106 29 respectively respectively RB cord-005453-4057qib7 7106 30 . . . cord-005453-4057qib7 7107 1 Four four CD cord-005453-4057qib7 7107 2 patients patient NNS cord-005453-4057qib7 7107 3 had have VBD cord-005453-4057qib7 7107 4 platelet platelet NN cord-005453-4057qib7 7107 5 engraftment engraftment NN cord-005453-4057qib7 7107 6 ≥ ≥ NNP cord-005453-4057qib7 7107 7 Day Day NNP cord-005453-4057qib7 7107 8 60 60 CD cord-005453-4057qib7 7107 9 and and CC cord-005453-4057qib7 7107 10 four four CD cord-005453-4057qib7 7107 11 patients patient NNS cord-005453-4057qib7 7107 12 had have VBD cord-005453-4057qib7 7107 13 platelet platelet NN cord-005453-4057qib7 7107 14 counts count NNS cord-005453-4057qib7 7107 15 of of IN cord-005453-4057qib7 7107 16 ≤ ≤ NNS cord-005453-4057qib7 7107 17 100x10 100x10 CD cord-005453-4057qib7 7107 18 9 9 CD cord-005453-4057qib7 7107 19 /L /L . cord-005453-4057qib7 7107 20 at at IN cord-005453-4057qib7 7107 21 Month month NN cord-005453-4057qib7 7107 22 12 12 CD cord-005453-4057qib7 7107 23 . . . cord-005453-4057qib7 7108 1 None none NN cord-005453-4057qib7 7108 2 of of IN cord-005453-4057qib7 7108 3 these these DT cord-005453-4057qib7 7108 4 patients patient NNS cord-005453-4057qib7 7108 5 had have VBD cord-005453-4057qib7 7108 6 ≥ ≥ CD cord-005453-4057qib7 7108 7 grade grade NN cord-005453-4057qib7 7108 8 3 3 CD cord-005453-4057qib7 7108 9 bleeding bleed VBG cord-005453-4057qib7 7108 10 events event NNS cord-005453-4057qib7 7108 11 post post VBP cord-005453-4057qib7 7108 12 - - JJ cord-005453-4057qib7 7108 13 LentiGlobin LentiGlobin NNP cord-005453-4057qib7 7108 14 infusion infusion NN cord-005453-4057qib7 7108 15 . . . cord-005453-4057qib7 7109 1 Transfusion transfusion NN cord-005453-4057qib7 7109 2 independence independence NN cord-005453-4057qib7 7109 3 ( ( -LRB- cord-005453-4057qib7 7109 4 TI TI NNP cord-005453-4057qib7 7109 5 , , , cord-005453-4057qib7 7109 6 defined define VBN cord-005453-4057qib7 7109 7 as as IN cord-005453-4057qib7 7109 8 weighted weighted JJ cord-005453-4057qib7 7109 9 average average JJ cord-005453-4057qib7 7109 10 Hb Hb NNP cord-005453-4057qib7 7109 11 ≥ ≥ CD cord-005453-4057qib7 7109 12 9 9 CD cord-005453-4057qib7 7109 13 g g NN cord-005453-4057qib7 7109 14 / / SYM cord-005453-4057qib7 7109 15 dL dl NN cord-005453-4057qib7 7109 16 without without IN cord-005453-4057qib7 7109 17 RBC RBC NNP cord-005453-4057qib7 7109 18 transfusions transfusion NNS cord-005453-4057qib7 7109 19 for for IN cord-005453-4057qib7 7109 20 ≥ ≥ CD cord-005453-4057qib7 7109 21 12 12 CD cord-005453-4057qib7 7109 22 months month NNS cord-005453-4057qib7 7109 23 ) ) -RRB- cord-005453-4057qib7 7109 24 was be VBD cord-005453-4057qib7 7109 25 achieved achieve VBN cord-005453-4057qib7 7109 26 in in IN cord-005453-4057qib7 7109 27 8/10 8/10 CD cord-005453-4057qib7 7109 28 patients patient NNS cord-005453-4057qib7 7109 29 with with IN cord-005453-4057qib7 7109 30 non non AFX cord-005453-4057qib7 7109 31 - - JJ cord-005453-4057qib7 7109 32 β β JJ cord-005453-4057qib7 7109 33 0 0 CD cord-005453-4057qib7 7109 34 /β /β NN cord-005453-4057qib7 7109 35 0 0 NFP cord-005453-4057qib7 7109 36 genotypes genotype NNS cord-005453-4057qib7 7109 37 and and CC cord-005453-4057qib7 7109 38 3/8 3/8 CD cord-005453-4057qib7 7109 39 patients patient NNS cord-005453-4057qib7 7109 40 with with IN cord-005453-4057qib7 7109 41 β β NN cord-005453-4057qib7 7109 42 0 0 CD cord-005453-4057qib7 7109 43 /β /β NN cord-005453-4057qib7 7109 44 0 0 NFP cord-005453-4057qib7 7109 45 genotypes genotype NNS cord-005453-4057qib7 7109 46 . . . cord-005453-4057qib7 7110 1 In in IN cord-005453-4057qib7 7110 2 patients patient NNS cord-005453-4057qib7 7110 3 who who WP cord-005453-4057qib7 7110 4 achieved achieve VBD cord-005453-4057qib7 7110 5 TI TI NNP cord-005453-4057qib7 7110 6 , , , cord-005453-4057qib7 7110 7 total total JJ cord-005453-4057qib7 7110 8 Hb Hb NNP cord-005453-4057qib7 7110 9 at at IN cord-005453-4057qib7 7110 10 last last JJ cord-005453-4057qib7 7110 11 visit visit NN cord-005453-4057qib7 7110 12 was be VBD cord-005453-4057qib7 7110 13 9.1 9.1 CD cord-005453-4057qib7 7110 14 -14.1 -14.1 CD cord-005453-4057qib7 7111 1 g g NNP cord-005453-4057qib7 7111 2 / / SYM cord-005453-4057qib7 7111 3 dL. dL. NNP cord-005453-4057qib7 7111 4 LIC LIC NNP cord-005453-4057qib7 7111 5 increased increase VBD cord-005453-4057qib7 7111 6 from from IN cord-005453-4057qib7 7111 7 baseline baseline NN cord-005453-4057qib7 7111 8 in in IN cord-005453-4057qib7 7111 9 patients patient NNS cord-005453-4057qib7 7111 10 who who WP cord-005453-4057qib7 7111 11 achieved achieve VBD cord-005453-4057qib7 7111 12 TI TI NNP cord-005453-4057qib7 7111 13 by by IN cord-005453-4057qib7 7111 14 a a DT cord-005453-4057qib7 7111 15 median median NN cord-005453-4057qib7 7111 16 of of IN cord-005453-4057qib7 7111 17 55.6 55.6 CD cord-005453-4057qib7 7111 18 % % NN cord-005453-4057qib7 7111 19 and and CC cord-005453-4057qib7 7111 20 12.5 12.5 CD cord-005453-4057qib7 7111 21 % % NN cord-005453-4057qib7 7111 22 at at IN cord-005453-4057qib7 7111 23 Month month NN cord-005453-4057qib7 7111 24 12 12 CD cord-005453-4057qib7 7111 25 and and CC cord-005453-4057qib7 7111 26 24 24 CD cord-005453-4057qib7 7111 27 then then RB cord-005453-4057qib7 7111 28 decreased decrease VBD cord-005453-4057qib7 7111 29 from from IN cord-005453-4057qib7 7111 30 baseline baseline NN cord-005453-4057qib7 7111 31 by by IN cord-005453-4057qib7 7111 32 a a DT cord-005453-4057qib7 7111 33 median median NN cord-005453-4057qib7 7111 34 of of IN cord-005453-4057qib7 7111 35 9.2 9.2 CD cord-005453-4057qib7 7111 36 % % NN cord-005453-4057qib7 7111 37 and and CC cord-005453-4057qib7 7111 38 44.4 44.4 CD cord-005453-4057qib7 7111 39 % % NN cord-005453-4057qib7 7111 40 at at IN cord-005453-4057qib7 7111 41 Month Month NNP cord-005453-4057qib7 7111 42 36 36 CD cord-005453-4057qib7 7111 43 and and CC cord-005453-4057qib7 7111 44 48 48 CD cord-005453-4057qib7 7111 45 , , , cord-005453-4057qib7 7111 46 respectively respectively RB cord-005453-4057qib7 7111 47 . . . cord-005453-4057qib7 7112 1 Non non JJ cord-005453-4057qib7 7112 2 - - JJ cord-005453-4057qib7 7112 3 hematologic hematologic JJ cord-005453-4057qib7 7112 4 grade grade NN cord-005453-4057qib7 7113 1 ≥ ≥ CD cord-005453-4057qib7 7113 2 3 3 CD cord-005453-4057qib7 7113 3 adverse adverse JJ cord-005453-4057qib7 7113 4 events event NNS cord-005453-4057qib7 7113 5 post post NN cord-005453-4057qib7 7113 6 - - NN cord-005453-4057qib7 7113 7 infusion infusion NN cord-005453-4057qib7 7113 8 in in IN cord-005453-4057qib7 7113 9 ≥ ≥ CD cord-005453-4057qib7 7113 10 3 3 CD cord-005453-4057qib7 7113 11 patients patient NNS cord-005453-4057qib7 7113 12 included include VBD cord-005453-4057qib7 7113 13 stomatitis stomatitis NN cord-005453-4057qib7 7113 14 , , , cord-005453-4057qib7 7113 15 febrile febrile JJ cord-005453-4057qib7 7113 16 neutropenia neutropenia NN cord-005453-4057qib7 7113 17 , , , cord-005453-4057qib7 7113 18 pharyngeal pharyngeal JJ cord-005453-4057qib7 7113 19 inflammation inflammation NN cord-005453-4057qib7 7113 20 , , , cord-005453-4057qib7 7113 21 and and CC cord-005453-4057qib7 7113 22 irregular irregular JJ cord-005453-4057qib7 7113 23 menstruation menstruation NN cord-005453-4057qib7 7113 24 . . . cord-005453-4057qib7 7114 1 There there EX cord-005453-4057qib7 7114 2 was be VBD cord-005453-4057qib7 7114 3 no no DT cord-005453-4057qib7 7114 4 transplant transplant NN cord-005453-4057qib7 7114 5 - - HYPH cord-005453-4057qib7 7114 6 related relate VBN cord-005453-4057qib7 7114 7 mortality mortality NN cord-005453-4057qib7 7114 8 , , , cord-005453-4057qib7 7114 9 vector vector NN cord-005453-4057qib7 7114 10 - - HYPH cord-005453-4057qib7 7114 11 mediated mediate VBN cord-005453-4057qib7 7114 12 replication replication NN cord-005453-4057qib7 7114 13 competent competent JJ cord-005453-4057qib7 7114 14 lentivirus lentivirus NN cord-005453-4057qib7 7114 15 , , , cord-005453-4057qib7 7114 16 or or CC cord-005453-4057qib7 7114 17 clonal clonal JJ cord-005453-4057qib7 7114 18 dominance dominance NN cord-005453-4057qib7 7114 19 . . . cord-005453-4057qib7 7115 1 Two two CD cord-005453-4057qib7 7115 2 patients patient NNS cord-005453-4057qib7 7115 3 experienced experience VBD cord-005453-4057qib7 7115 4 grade grade NN cord-005453-4057qib7 7115 5 3 3 CD cord-005453-4057qib7 7115 6 serious serious JJ cord-005453-4057qib7 7115 7 veno veno NN cord-005453-4057qib7 7115 8 - - HYPH cord-005453-4057qib7 7115 9 occlusive occlusive JJ cord-005453-4057qib7 7115 10 liver liver NN cord-005453-4057qib7 7115 11 disease disease NN cord-005453-4057qib7 7115 12 ( ( -LRB- cord-005453-4057qib7 7115 13 Table table NN cord-005453-4057qib7 7115 14 1 1 CD cord-005453-4057qib7 7115 15 ) ) -RRB- cord-005453-4057qib7 7115 16 . . . cord-005453-4057qib7 7116 1 Events event NNS cord-005453-4057qib7 7116 2 resolved resolve VBD cord-005453-4057qib7 7116 3 following follow VBG cord-005453-4057qib7 7116 4 treatment treatment NN cord-005453-4057qib7 7116 5 with with IN cord-005453-4057qib7 7116 6 defibrotide defibrotide NN cord-005453-4057qib7 7116 7 and and CC cord-005453-4057qib7 7116 8 were be VBD cord-005453-4057qib7 7116 9 attributed attribute VBN cord-005453-4057qib7 7116 10 to to IN cord-005453-4057qib7 7116 11 myeloablative myeloablative NNP cord-005453-4057qib7 7116 12 conditioning conditioning NN cord-005453-4057qib7 7116 13 . . . cord-005453-4057qib7 7117 1 Conclusions conclusion NNS cord-005453-4057qib7 7117 2 : : : cord-005453-4057qib7 7118 1 In in IN cord-005453-4057qib7 7118 2 the the DT cord-005453-4057qib7 7118 3 Northstar Northstar NNP cord-005453-4057qib7 7118 4 study study NN cord-005453-4057qib7 7118 5 , , , cord-005453-4057qib7 7118 6 80 80 CD cord-005453-4057qib7 7118 7 % % NN cord-005453-4057qib7 7118 8 of of IN cord-005453-4057qib7 7118 9 patients patient NNS cord-005453-4057qib7 7118 10 with with IN cord-005453-4057qib7 7118 11 TDT TDT NNP cord-005453-4057qib7 7118 12 and and CC cord-005453-4057qib7 7118 13 non non NNS cord-005453-4057qib7 7118 14 - - JJ cord-005453-4057qib7 7118 15 β β JJ cord-005453-4057qib7 7118 16 0 0 CD cord-005453-4057qib7 7118 17 /β /β NN cord-005453-4057qib7 7118 18 0 0 NFP cord-005453-4057qib7 7118 19 genotypes genotype NNS cord-005453-4057qib7 7118 20 and and CC cord-005453-4057qib7 7118 21 38 38 CD cord-005453-4057qib7 7118 22 % % NN cord-005453-4057qib7 7118 23 of of IN cord-005453-4057qib7 7118 24 patients patient NNS cord-005453-4057qib7 7118 25 with with IN cord-005453-4057qib7 7118 26 β β NN cord-005453-4057qib7 7118 27 0 0 CD cord-005453-4057qib7 7118 28 / / NFP cord-005453-4057qib7 7119 1 β β NN cord-005453-4057qib7 7119 2 0 0 CD cord-005453-4057qib7 7119 3 genotypes genotype NNS cord-005453-4057qib7 7119 4 achieved achieve VBD cord-005453-4057qib7 7119 5 transfusion transfusion NN cord-005453-4057qib7 7119 6 independence independence NN cord-005453-4057qib7 7119 7 . . . cord-005453-4057qib7 7120 1 The the DT cord-005453-4057qib7 7120 2 safety safety NN cord-005453-4057qib7 7120 3 profile profile NN cord-005453-4057qib7 7120 4 of of IN cord-005453-4057qib7 7120 5 LentiGlobin LentiGlobin NNP cord-005453-4057qib7 7120 6 remains remain VBZ cord-005453-4057qib7 7120 7 consistent consistent JJ cord-005453-4057qib7 7120 8 with with IN cord-005453-4057qib7 7120 9 myeloablative myeloablative NNP cord-005453-4057qib7 7120 10 busulfan busulfan NNP cord-005453-4057qib7 7120 11 conditioning conditioning NN cord-005453-4057qib7 7120 12 . . . cord-005453-4057qib7 7121 1 Longer long JJR cord-005453-4057qib7 7121 2 time time NN cord-005453-4057qib7 7121 3 to to IN cord-005453-4057qib7 7121 4 platelet platelet NN cord-005453-4057qib7 7121 5 engraftment engraftment NN cord-005453-4057qib7 7121 6 was be VBD cord-005453-4057qib7 7121 7 observed observe VBN cord-005453-4057qib7 7121 8 in in IN cord-005453-4057qib7 7121 9 some some DT cord-005453-4057qib7 7121 10 patients patient NNS cord-005453-4057qib7 7121 11 , , , cord-005453-4057qib7 7121 12 but but CC cord-005453-4057qib7 7121 13 no no DT cord-005453-4057qib7 7121 14 graft graft NN cord-005453-4057qib7 7121 15 failure failure NN cord-005453-4057qib7 7121 16 was be VBD cord-005453-4057qib7 7121 17 reported report VBN cord-005453-4057qib7 7121 18 . . . cord-005453-4057qib7 7122 1 Clinical clinical JJ cord-005453-4057qib7 7122 2 Background Background NNP cord-005453-4057qib7 7122 3 : : : cord-005453-4057qib7 7122 4 Sickle Sickle NNP cord-005453-4057qib7 7122 5 Cell Cell NNP cord-005453-4057qib7 7122 6 Disease Disease NNP cord-005453-4057qib7 7122 7 ( ( -LRB- cord-005453-4057qib7 7122 8 SCD SCD NNP cord-005453-4057qib7 7122 9 ) ) -RRB- cord-005453-4057qib7 7122 10 is be VBZ cord-005453-4057qib7 7122 11 an an DT cord-005453-4057qib7 7122 12 inherited inherit VBN cord-005453-4057qib7 7122 13 hemoglobin hemoglobin NN cord-005453-4057qib7 7122 14 disorder disorder NN cord-005453-4057qib7 7122 15 associated associate VBN cord-005453-4057qib7 7122 16 with with IN cord-005453-4057qib7 7122 17 high high JJ cord-005453-4057qib7 7122 18 morbidity morbidity NN cord-005453-4057qib7 7122 19 and and CC cord-005453-4057qib7 7122 20 mortality mortality NN cord-005453-4057qib7 7122 21 . . . cord-005453-4057qib7 7123 1 Currently currently RB cord-005453-4057qib7 7123 2 , , , cord-005453-4057qib7 7123 3 allogeneic allogeneic IN cord-005453-4057qib7 7123 4 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 7123 5 Stem Stem NNP cord-005453-4057qib7 7123 6 Cell cell NN cord-005453-4057qib7 7123 7 Transplantation transplantation NN cord-005453-4057qib7 7123 8 ( ( -LRB- cord-005453-4057qib7 7123 9 HSCT HSCT NNP cord-005453-4057qib7 7123 10 ) ) -RRB- cord-005453-4057qib7 7123 11 is be VBZ cord-005453-4057qib7 7123 12 the the DT cord-005453-4057qib7 7123 13 only only JJ cord-005453-4057qib7 7123 14 curative curative JJ cord-005453-4057qib7 7123 15 therapy therapy NN cord-005453-4057qib7 7123 16 for for IN cord-005453-4057qib7 7123 17 SCD SCD NNP cord-005453-4057qib7 7123 18 . . . cord-005453-4057qib7 7124 1 Transplant transplant NN cord-005453-4057qib7 7124 2 outcomes outcome NNS cord-005453-4057qib7 7124 3 with with IN cord-005453-4057qib7 7124 4 Thiotepa Thiotepa NNP cord-005453-4057qib7 7124 5 , , , cord-005453-4057qib7 7124 6 Treosulfan Treosulfan NNP cord-005453-4057qib7 7124 7 and and CC cord-005453-4057qib7 7124 8 Fludarabine Fludarabine NNP cord-005453-4057qib7 7124 9 ( ( -LRB- cord-005453-4057qib7 7124 10 TTF TTF NNP cord-005453-4057qib7 7124 11 ) ) -RRB- cord-005453-4057qib7 7125 1 preparative preparative JJ cord-005453-4057qib7 7125 2 regimen regimen NN cord-005453-4057qib7 7125 3 are be VBP cord-005453-4057qib7 7125 4 encouraging encourage VBG cord-005453-4057qib7 7125 5 but but CC cord-005453-4057qib7 7125 6 this this DT cord-005453-4057qib7 7125 7 regimen regimen NN cord-005453-4057qib7 7125 8 has have VBZ cord-005453-4057qib7 7125 9 not not RB cord-005453-4057qib7 7125 10 been be VBN cord-005453-4057qib7 7125 11 directly directly RB cord-005453-4057qib7 7125 12 compared compare VBN cord-005453-4057qib7 7125 13 to to IN cord-005453-4057qib7 7125 14 other other JJ cord-005453-4057qib7 7125 15 preparative preparative JJ cord-005453-4057qib7 7125 16 regimens regimen NNS cord-005453-4057qib7 7125 17 in in IN cord-005453-4057qib7 7125 18 SCD SCD NNP cord-005453-4057qib7 7125 19 . . . cord-005453-4057qib7 7126 1 We -PRON- PRP cord-005453-4057qib7 7126 2 therefore therefore RB cord-005453-4057qib7 7126 3 planned plan VBD cord-005453-4057qib7 7126 4 to to TO cord-005453-4057qib7 7126 5 compare compare VB cord-005453-4057qib7 7126 6 the the DT cord-005453-4057qib7 7126 7 event event NN cord-005453-4057qib7 7126 8 free free JJ cord-005453-4057qib7 7126 9 probability probability NN cord-005453-4057qib7 7126 10 for for IN cord-005453-4057qib7 7126 11 death death NN cord-005453-4057qib7 7126 12 , , , cord-005453-4057qib7 7126 13 rejection rejection NN cord-005453-4057qib7 7126 14 and and CC cord-005453-4057qib7 7126 15 high high JJ cord-005453-4057qib7 7126 16 grade grade NN cord-005453-4057qib7 7126 17 acute acute JJ cord-005453-4057qib7 7126 18 Graft graft NN cord-005453-4057qib7 7126 19 versus versus IN cord-005453-4057qib7 7126 20 Host Host NNP cord-005453-4057qib7 7126 21 Disease Disease NNP cord-005453-4057qib7 7126 22 ( ( -LRB- cord-005453-4057qib7 7126 23 aGvHD agvhd NN cord-005453-4057qib7 7126 24 ) ) -RRB- cord-005453-4057qib7 7126 25 between between IN cord-005453-4057qib7 7126 26 TTF TTF NNP cord-005453-4057qib7 7126 27 and and CC cord-005453-4057qib7 7126 28 Busulfan Busulfan NNP cord-005453-4057qib7 7126 29 and and CC cord-005453-4057qib7 7126 30 Fludarabine Fludarabine NNP cord-005453-4057qib7 7126 31 ( ( -LRB- cord-005453-4057qib7 7126 32 BF BF NNP cord-005453-4057qib7 7126 33 ) ) -RRB- cord-005453-4057qib7 7126 34 regimens regimen NNS cord-005453-4057qib7 7126 35 . . . cord-005453-4057qib7 7127 1 Methods method NNS cord-005453-4057qib7 7127 2 : : : cord-005453-4057qib7 7127 3 In in IN cord-005453-4057qib7 7127 4 this this DT cord-005453-4057qib7 7127 5 retrospectively retrospectively RB cord-005453-4057qib7 7127 6 cohort cohort JJ cord-005453-4057qib7 7127 7 study study NN cord-005453-4057qib7 7127 8 , , , cord-005453-4057qib7 7127 9 we -PRON- PRP cord-005453-4057qib7 7127 10 included include VBD cord-005453-4057qib7 7127 11 all all DT cord-005453-4057qib7 7127 12 patients patient NNS cord-005453-4057qib7 7127 13 with with IN cord-005453-4057qib7 7127 14 SCD SCD NNP cord-005453-4057qib7 7127 15 who who WP cord-005453-4057qib7 7127 16 received receive VBD cord-005453-4057qib7 7127 17 allogeneic allogeneic IN cord-005453-4057qib7 7127 18 HSCT HSCT NNP cord-005453-4057qib7 7127 19 at at IN cord-005453-4057qib7 7127 20 our -PRON- PRP$ cord-005453-4057qib7 7127 21 center center NN cord-005453-4057qib7 7127 22 or or CC cord-005453-4057qib7 7127 23 who who WP cord-005453-4057qib7 7127 24 were be VBD cord-005453-4057qib7 7127 25 transplanted transplant VBN cord-005453-4057qib7 7127 26 in in IN cord-005453-4057qib7 7127 27 other other JJ cord-005453-4057qib7 7127 28 centers center NNS cord-005453-4057qib7 7127 29 and and CC cord-005453-4057qib7 7127 30 referred refer VBD cord-005453-4057qib7 7127 31 to to IN cord-005453-4057qib7 7127 32 ours -PRON- PRP cord-005453-4057qib7 7127 33 for for IN cord-005453-4057qib7 7127 34 follow follow NN cord-005453-4057qib7 7127 35 up up RP cord-005453-4057qib7 7127 36 before before IN cord-005453-4057qib7 7127 37 day day NN cord-005453-4057qib7 7127 38 100 100 CD cord-005453-4057qib7 7127 39 . . . cord-005453-4057qib7 7128 1 Patients patient NNS cord-005453-4057qib7 7128 2 were be VBD cord-005453-4057qib7 7128 3 transplanted transplant VBN cord-005453-4057qib7 7128 4 between between IN cord-005453-4057qib7 7128 5 July July NNP cord-005453-4057qib7 7128 6 2007 2007 CD cord-005453-4057qib7 7128 7 and and CC cord-005453-4057qib7 7128 8 December December NNP cord-005453-4057qib7 7128 9 2017 2017 CD cord-005453-4057qib7 7128 10 . . . cord-005453-4057qib7 7129 1 We -PRON- PRP cord-005453-4057qib7 7129 2 used use VBD cord-005453-4057qib7 7129 3 Kaplan Kaplan NNP cord-005453-4057qib7 7129 4 - - HYPH cord-005453-4057qib7 7129 5 Meier Meier NNP cord-005453-4057qib7 7129 6 curve curve NN cord-005453-4057qib7 7129 7 to to TO cord-005453-4057qib7 7129 8 estimate estimate VB cord-005453-4057qib7 7129 9 the the DT cord-005453-4057qib7 7129 10 event event NN cord-005453-4057qib7 7129 11 free free JJ cord-005453-4057qib7 7129 12 probability probability NN cord-005453-4057qib7 7129 13 for for IN cord-005453-4057qib7 7129 14 death death NN cord-005453-4057qib7 7129 15 , , , cord-005453-4057qib7 7129 16 rejection rejection NN cord-005453-4057qib7 7129 17 and and CC cord-005453-4057qib7 7129 18 high high JJ cord-005453-4057qib7 7129 19 grade grade NN cord-005453-4057qib7 7129 20 aGvHD agvhd NN cord-005453-4057qib7 7129 21 ( ( -LRB- cord-005453-4057qib7 7129 22 Grades grade NNS cord-005453-4057qib7 7129 23 3 3 CD cord-005453-4057qib7 7129 24 - - SYM cord-005453-4057qib7 7129 25 4 4 CD cord-005453-4057qib7 7129 26 ) ) -RRB- cord-005453-4057qib7 7129 27 . . . cord-005453-4057qib7 7130 1 Cox Cox NNP cord-005453-4057qib7 7130 2 regression regression NN cord-005453-4057qib7 7130 3 was be VBD cord-005453-4057qib7 7130 4 used use VBN cord-005453-4057qib7 7130 5 to to TO cord-005453-4057qib7 7130 6 assess assess VB cord-005453-4057qib7 7130 7 the the DT cord-005453-4057qib7 7130 8 impact impact NN cord-005453-4057qib7 7130 9 of of IN cord-005453-4057qib7 7130 10 the the DT cord-005453-4057qib7 7130 11 preparative preparative JJ cord-005453-4057qib7 7130 12 regimen regimen NN cord-005453-4057qib7 7130 13 on on IN cord-005453-4057qib7 7130 14 these these DT cord-005453-4057qib7 7130 15 outcomes outcome NNS cord-005453-4057qib7 7130 16 . . . cord-005453-4057qib7 7131 1 Results result NNS cord-005453-4057qib7 7131 2 : : : cord-005453-4057qib7 7132 1 A a DT cord-005453-4057qib7 7132 2 total total NN cord-005453-4057qib7 7132 3 of of IN cord-005453-4057qib7 7132 4 61 61 CD cord-005453-4057qib7 7132 5 patients patient NNS cord-005453-4057qib7 7132 6 were be VBD cord-005453-4057qib7 7132 7 included include VBN cord-005453-4057qib7 7132 8 with with IN cord-005453-4057qib7 7132 9 a a DT cord-005453-4057qib7 7132 10 median median JJ cord-005453-4057qib7 7132 11 age age NN cord-005453-4057qib7 7132 12 of of IN cord-005453-4057qib7 7132 13 20 20 CD cord-005453-4057qib7 7132 14 years year NNS cord-005453-4057qib7 7133 1 ( ( -LRB- cord-005453-4057qib7 7133 2 Interquartile Interquartile NNP cord-005453-4057qib7 7133 3 Range Range NNP cord-005453-4057qib7 7133 4 [ [ -LRB- cord-005453-4057qib7 7133 5 IQR IQR NNP cord-005453-4057qib7 7133 6 ] ] -RRB- cord-005453-4057qib7 7133 7 : : : cord-005453-4057qib7 7133 8 14 14 CD cord-005453-4057qib7 7133 9 - - SYM cord-005453-4057qib7 7133 10 26 26 CD cord-005453-4057qib7 7133 11 ) ) -RRB- cord-005453-4057qib7 7133 12 and and CC cord-005453-4057qib7 7133 13 a a DT cord-005453-4057qib7 7133 14 median median JJ cord-005453-4057qib7 7133 15 hemoglobin hemoglobin NN cord-005453-4057qib7 7133 16 of of IN cord-005453-4057qib7 7133 17 10 10 CD cord-005453-4057qib7 7133 18 g g NN cord-005453-4057qib7 7133 19 / / SYM cord-005453-4057qib7 7133 20 dL dl NN cord-005453-4057qib7 7133 21 ( ( -LRB- cord-005453-4057qib7 7133 22 IQR iqr NN cord-005453-4057qib7 7133 23 : : : cord-005453-4057qib7 7133 24 9 9 CD cord-005453-4057qib7 7133 25 - - SYM cord-005453-4057qib7 7133 26 10 10 CD cord-005453-4057qib7 7133 27 ) ) -RRB- cord-005453-4057qib7 7133 28 . . . cord-005453-4057qib7 7134 1 Sixtytwo Sixtytwo NNP cord-005453-4057qib7 7134 2 percent percent NN cord-005453-4057qib7 7134 3 were be VBD cord-005453-4057qib7 7134 4 males male NNS cord-005453-4057qib7 7134 5 . . . cord-005453-4057qib7 7135 1 The the DT cord-005453-4057qib7 7135 2 proportion proportion NN cord-005453-4057qib7 7135 3 of of IN cord-005453-4057qib7 7135 4 patients patient NNS cord-005453-4057qib7 7135 5 who who WP cord-005453-4057qib7 7135 6 had have VBD cord-005453-4057qib7 7135 7 splenectomy splenectomy NN cord-005453-4057qib7 7135 8 , , , cord-005453-4057qib7 7135 9 stroke stroke NN cord-005453-4057qib7 7135 10 and and CC cord-005453-4057qib7 7135 11 acute acute JJ cord-005453-4057qib7 7135 12 chest chest NN cord-005453-4057qib7 7135 13 syndrome syndrome NN cord-005453-4057qib7 7135 14 was be VBD cord-005453-4057qib7 7135 15 34 34 CD cord-005453-4057qib7 7135 16 % % NN cord-005453-4057qib7 7135 17 , , , cord-005453-4057qib7 7135 18 23 23 CD cord-005453-4057qib7 7135 19 % % NN cord-005453-4057qib7 7135 20 and and CC cord-005453-4057qib7 7135 21 57 57 CD cord-005453-4057qib7 7135 22 % % NN cord-005453-4057qib7 7135 23 respectively respectively RB cord-005453-4057qib7 7135 24 . . . cord-005453-4057qib7 7136 1 All all DT cord-005453-4057qib7 7136 2 patients patient NNS cord-005453-4057qib7 7136 3 received receive VBD cord-005453-4057qib7 7136 4 peripherally peripherally RB cord-005453-4057qib7 7136 5 collected collect VBN cord-005453-4057qib7 7136 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 7136 7 stem stem NN cord-005453-4057qib7 7136 8 cells cell NNS cord-005453-4057qib7 7136 9 from from IN cord-005453-4057qib7 7136 10 a a DT cord-005453-4057qib7 7136 11 matched match VBN cord-005453-4057qib7 7136 12 sibling sibling NN cord-005453-4057qib7 7136 13 donor donor NN cord-005453-4057qib7 7136 14 with with IN cord-005453-4057qib7 7136 15 a a DT cord-005453-4057qib7 7136 16 median median JJ cord-005453-4057qib7 7136 17 stem stem NN cord-005453-4057qib7 7136 18 cell cell NN cord-005453-4057qib7 7136 19 dose dose NN cord-005453-4057qib7 7136 20 of of IN cord-005453-4057qib7 7136 21 6 6 CD cord-005453-4057qib7 7136 22 x x SYM cord-005453-4057qib7 7136 23 10 10 CD cord-005453-4057qib7 7136 24 6 6 CD cord-005453-4057qib7 7137 1 /Kg /Kg . cord-005453-4057qib7 7138 1 ( ( -LRB- cord-005453-4057qib7 7138 2 IQR IQR NNP cord-005453-4057qib7 7138 3 : : : cord-005453-4057qib7 7138 4 5 5 CD cord-005453-4057qib7 7138 5 . . . cord-005453-4057qib7 7138 6 1 1 CD cord-005453-4057qib7 7138 7 - - SYM cord-005453-4057qib7 7138 8 8.8 8.8 CD cord-005453-4057qib7 7138 9 ) ) -RRB- cord-005453-4057qib7 7138 10 . . . cord-005453-4057qib7 7139 1 Most Most JJS cord-005453-4057qib7 7139 2 patients patient NNS cord-005453-4057qib7 7139 3 , , , cord-005453-4057qib7 7139 4 95 95 CD cord-005453-4057qib7 7139 5 % % NN cord-005453-4057qib7 7139 6 , , , cord-005453-4057qib7 7139 7 received receive VBD cord-005453-4057qib7 7139 8 cyclosporine cyclosporine NN cord-005453-4057qib7 7139 9 or or CC cord-005453-4057qib7 7139 10 tacrolimus tacrolimus NN cord-005453-4057qib7 7139 11 based base VBN cord-005453-4057qib7 7139 12 aGvHD aGvHD NNP cord-005453-4057qib7 7139 13 prophylaxis prophylaxis NNP cord-005453-4057qib7 7139 14 . . . cord-005453-4057qib7 7140 1 Most Most JJS cord-005453-4057qib7 7140 2 patients patient NNS cord-005453-4057qib7 7140 3 received receive VBD cord-005453-4057qib7 7140 4 TTF TTF NNP cord-005453-4057qib7 7140 5 ( ( -LRB- cord-005453-4057qib7 7140 6 41 41 CD cord-005453-4057qib7 7140 7 % % NN cord-005453-4057qib7 7140 8 ) ) -RRB- cord-005453-4057qib7 7140 9 or or CC cord-005453-4057qib7 7140 10 BF BF NNP cord-005453-4057qib7 7140 11 ( ( -LRB- cord-005453-4057qib7 7140 12 53 53 CD cord-005453-4057qib7 7140 13 % % NN cord-005453-4057qib7 7140 14 ) ) -RRB- cord-005453-4057qib7 7140 15 preparative preparative JJ cord-005453-4057qib7 7140 16 regimens regimen NNS cord-005453-4057qib7 7140 17 . . . cord-005453-4057qib7 7141 1 All all DT cord-005453-4057qib7 7141 2 patients patient NNS cord-005453-4057qib7 7141 3 in in IN cord-005453-4057qib7 7141 4 the the DT cord-005453-4057qib7 7141 5 BF BF NNP cord-005453-4057qib7 7141 6 group group NN cord-005453-4057qib7 7141 7 received receive VBD cord-005453-4057qib7 7141 8 ATG ATG NNP cord-005453-4057qib7 7141 9 . . . cord-005453-4057qib7 7142 1 The the DT cord-005453-4057qib7 7142 2 median median JJ cord-005453-4057qib7 7142 3 follow follow NN cord-005453-4057qib7 7142 4 - - HYPH cord-005453-4057qib7 7142 5 up up RP cord-005453-4057qib7 7142 6 time time NN cord-005453-4057qib7 7142 7 was be VBD cord-005453-4057qib7 7142 8 44 44 CD cord-005453-4057qib7 7142 9 months month NNS cord-005453-4057qib7 7143 1 ( ( -LRB- cord-005453-4057qib7 7143 2 Range range NN cord-005453-4057qib7 7143 3 : : : cord-005453-4057qib7 7143 4 2 2 CD cord-005453-4057qib7 7143 5 - - SYM cord-005453-4057qib7 7143 6 127 127 CD cord-005453-4057qib7 7143 7 ) ) -RRB- cord-005453-4057qib7 7143 8 . . . cord-005453-4057qib7 7144 1 Four four CD cord-005453-4057qib7 7144 2 patients patient NNS cord-005453-4057qib7 7144 3 died die VBD cord-005453-4057qib7 7144 4 during during IN cord-005453-4057qib7 7144 5 the the DT cord-005453-4057qib7 7144 6 follow follow NN cord-005453-4057qib7 7144 7 - - HYPH cord-005453-4057qib7 7144 8 up up NN cord-005453-4057qib7 7144 9 period period NN cord-005453-4057qib7 7144 10 with with IN cord-005453-4057qib7 7144 11 an an DT cord-005453-4057qib7 7144 12 OS os NN cord-005453-4057qib7 7144 13 of of IN cord-005453-4057qib7 7144 14 93 93 CD cord-005453-4057qib7 7144 15 % % NN cord-005453-4057qib7 7144 16 ( ( -LRB- cord-005453-4057qib7 7144 17 95 95 CD cord-005453-4057qib7 7144 18 % % NN cord-005453-4057qib7 7144 19 Confidence confidence NN cord-005453-4057qib7 7144 20 Interval interval NN cord-005453-4057qib7 7144 21 [ [ -LRB- cord-005453-4057qib7 7144 22 CI CI NNP cord-005453-4057qib7 7144 23 ] ] -RRB- cord-005453-4057qib7 7144 24 : : : cord-005453-4057qib7 7144 25 87%-100 87%-100 CD cord-005453-4057qib7 7144 26 % % NN cord-005453-4057qib7 7144 27 ) ) -RRB- cord-005453-4057qib7 7144 28 at at IN cord-005453-4057qib7 7144 29 5 5 CD cord-005453-4057qib7 7144 30 years year NNS cord-005453-4057qib7 7144 31 . . . cord-005453-4057qib7 7145 1 The the DT cord-005453-4057qib7 7145 2 OS OS NNP cord-005453-4057qib7 7145 3 was be VBD cord-005453-4057qib7 7145 4 not not RB cord-005453-4057qib7 7145 5 different different JJ cord-005453-4057qib7 7145 6 ( ( -LRB- cord-005453-4057qib7 7145 7 HR HR NNP cord-005453-4057qib7 7145 8 1.3 1.3 CD cord-005453-4057qib7 7145 9 , , , cord-005453-4057qib7 7145 10 p p NN cord-005453-4057qib7 7145 11 = = SYM cord-005453-4057qib7 7145 12 0.82 0.82 CD cord-005453-4057qib7 7145 13 ) ) -RRB- cord-005453-4057qib7 7145 14 between between IN cord-005453-4057qib7 7145 15 the the DT cord-005453-4057qib7 7145 16 TTF TTF NNP cord-005453-4057qib7 7145 17 ( ( -LRB- cord-005453-4057qib7 7145 18 91 91 CD cord-005453-4057qib7 7145 19 % % NN cord-005453-4057qib7 7145 20 ) ) -RRB- cord-005453-4057qib7 7145 21 and and CC cord-005453-4057qib7 7145 22 the the DT cord-005453-4057qib7 7145 23 BF BF NNP cord-005453-4057qib7 7145 24 ( ( -LRB- cord-005453-4057qib7 7145 25 94 94 CD cord-005453-4057qib7 7145 26 % % NN cord-005453-4057qib7 7145 27 ) ) -RRB- cord-005453-4057qib7 7145 28 regimens regimen NNS cord-005453-4057qib7 7145 29 . . . cord-005453-4057qib7 7146 1 The the DT cord-005453-4057qib7 7146 2 probability probability NN cord-005453-4057qib7 7146 3 of of IN cord-005453-4057qib7 7146 4 high high JJ cord-005453-4057qib7 7146 5 grade grade NN cord-005453-4057qib7 7146 6 aGvHD aGvHD . cord-005453-4057qib7 7146 7 free free JJ cord-005453-4057qib7 7146 8 survival survival NN cord-005453-4057qib7 7146 9 at at IN cord-005453-4057qib7 7146 10 day day NN cord-005453-4057qib7 7146 11 100 100 CD cord-005453-4057qib7 7146 12 was be VBD cord-005453-4057qib7 7146 13 91 91 CD cord-005453-4057qib7 7146 14 % % NN cord-005453-4057qib7 7146 15 ( ( -LRB- cord-005453-4057qib7 7146 16 95 95 CD cord-005453-4057qib7 7146 17 % % NN cord-005453-4057qib7 7146 18 CI ci NN cord-005453-4057qib7 7146 19 : : : cord-005453-4057qib7 7146 20 84 84 CD cord-005453-4057qib7 7146 21 - - SYM cord-005453-4057qib7 7146 22 99 99 CD cord-005453-4057qib7 7146 23 ) ) -RRB- cord-005453-4057qib7 7146 24 for for IN cord-005453-4057qib7 7146 25 all all DT cord-005453-4057qib7 7146 26 patients patient NNS cord-005453-4057qib7 7146 27 . . . cord-005453-4057qib7 7147 1 This this DT cord-005453-4057qib7 7147 2 probability probability NN cord-005453-4057qib7 7147 3 was be VBD cord-005453-4057qib7 7147 4 85 85 CD cord-005453-4057qib7 7147 5 % % NN cord-005453-4057qib7 7147 6 in in IN cord-005453-4057qib7 7147 7 the the DT cord-005453-4057qib7 7147 8 TTF TTF NNP cord-005453-4057qib7 7147 9 group group NN cord-005453-4057qib7 7147 10 and and CC cord-005453-4057qib7 7147 11 93 93 CD cord-005453-4057qib7 7147 12 % % NN cord-005453-4057qib7 7147 13 in in IN cord-005453-4057qib7 7147 14 the the DT cord-005453-4057qib7 7147 15 BF BF NNP cord-005453-4057qib7 7147 16 group group NN cord-005453-4057qib7 7147 17 and and CC cord-005453-4057qib7 7147 18 the the DT cord-005453-4057qib7 7147 19 difference difference NN cord-005453-4057qib7 7147 20 was be VBD cord-005453-4057qib7 7147 21 not not RB cord-005453-4057qib7 7147 22 statistically statistically RB cord-005453-4057qib7 7147 23 significant significant JJ cord-005453-4057qib7 7147 24 ( ( -LRB- cord-005453-4057qib7 7147 25 HR HR NNP cord-005453-4057qib7 7147 26 2.2 2.2 CD cord-005453-4057qib7 7147 27 , , , cord-005453-4057qib7 7147 28 p p NN cord-005453-4057qib7 7147 29 = = SYM cord-005453-4057qib7 7147 30 0.39 0.39 CD cord-005453-4057qib7 7147 31 ) ) -RRB- cord-005453-4057qib7 7147 32 . . . cord-005453-4057qib7 7148 1 The the DT cord-005453-4057qib7 7148 2 rejection rejection NN cord-005453-4057qib7 7148 3 free free JJ cord-005453-4057qib7 7148 4 survival survival NN cord-005453-4057qib7 7148 5 at at IN cord-005453-4057qib7 7148 6 12 12 CD cord-005453-4057qib7 7148 7 months month NNS cord-005453-4057qib7 7148 8 was be VBD cord-005453-4057qib7 7148 9 93 93 CD cord-005453-4057qib7 7148 10 % % NN cord-005453-4057qib7 7148 11 ( ( -LRB- cord-005453-4057qib7 7148 12 95 95 CD cord-005453-4057qib7 7148 13 % % NN cord-005453-4057qib7 7148 14 CI ci NN cord-005453-4057qib7 7148 15 : : : cord-005453-4057qib7 7148 16 87 87 CD cord-005453-4057qib7 7148 17 - - SYM cord-005453-4057qib7 7148 18 100 100 CD cord-005453-4057qib7 7148 19 ) ) -RRB- cord-005453-4057qib7 7148 20 for for IN cord-005453-4057qib7 7148 21 all all DT cord-005453-4057qib7 7148 22 patients patient NNS cord-005453-4057qib7 7148 23 . . . cord-005453-4057qib7 7149 1 No no DT cord-005453-4057qib7 7149 2 patients patient NNS cord-005453-4057qib7 7149 3 in in IN cord-005453-4057qib7 7149 4 the the DT cord-005453-4057qib7 7149 5 TTF TTF NNP cord-005453-4057qib7 7149 6 group group NN cord-005453-4057qib7 7149 7 rejected reject VBD cord-005453-4057qib7 7149 8 while while IN cord-005453-4057qib7 7149 9 the the DT cord-005453-4057qib7 7149 10 rejection rejection NN cord-005453-4057qib7 7149 11 free free JJ cord-005453-4057qib7 7149 12 survival survival NN cord-005453-4057qib7 7149 13 at at IN cord-005453-4057qib7 7149 14 12 12 CD cord-005453-4057qib7 7149 15 months month NNS cord-005453-4057qib7 7149 16 for for IN cord-005453-4057qib7 7149 17 the the DT cord-005453-4057qib7 7149 18 BF BF NNP cord-005453-4057qib7 7149 19 group group NN cord-005453-4057qib7 7149 20 was be VBD cord-005453-4057qib7 7149 21 90 90 CD cord-005453-4057qib7 7149 22 % % NN cord-005453-4057qib7 7149 23 . . . cord-005453-4057qib7 7150 1 This this DT cord-005453-4057qib7 7150 2 was be VBD cord-005453-4057qib7 7150 3 not not RB cord-005453-4057qib7 7150 4 statistically statistically RB cord-005453-4057qib7 7150 5 significant significant JJ cord-005453-4057qib7 7150 6 ( ( -LRB- cord-005453-4057qib7 7150 7 p p NN cord-005453-4057qib7 7150 8 = = SYM cord-005453-4057qib7 7150 9 0.07 0.07 CD cord-005453-4057qib7 7150 10 ) ) -RRB- cord-005453-4057qib7 7150 11 . . . cord-005453-4057qib7 7151 1 Conclusions conclusion NNS cord-005453-4057qib7 7151 2 : : : cord-005453-4057qib7 7152 1 In in IN cord-005453-4057qib7 7152 2 patients patient NNS cord-005453-4057qib7 7152 3 with with IN cord-005453-4057qib7 7152 4 SCD SCD NNP cord-005453-4057qib7 7152 5 undergoing undergoing NN cord-005453-4057qib7 7152 6 allogeneic allogeneic IN cord-005453-4057qib7 7152 7 HSCT HSCT NNP cord-005453-4057qib7 7152 8 from from IN cord-005453-4057qib7 7152 9 a a DT cord-005453-4057qib7 7152 10 matched match VBN cord-005453-4057qib7 7152 11 sibling sibling NN cord-005453-4057qib7 7152 12 donor donor NN cord-005453-4057qib7 7152 13 , , , cord-005453-4057qib7 7152 14 the the DT cord-005453-4057qib7 7152 15 TTF TTF NNP cord-005453-4057qib7 7152 16 preparative preparative JJ cord-005453-4057qib7 7152 17 regimen regimen NN cord-005453-4057qib7 7152 18 is be VBZ cord-005453-4057qib7 7152 19 not not RB cord-005453-4057qib7 7152 20 associated associate VBN cord-005453-4057qib7 7152 21 with with IN cord-005453-4057qib7 7152 22 improved improved JJ cord-005453-4057qib7 7152 23 OS OS NNP cord-005453-4057qib7 7152 24 , , , cord-005453-4057qib7 7152 25 rejection rejection NN cord-005453-4057qib7 7152 26 free free JJ cord-005453-4057qib7 7152 27 or or CC cord-005453-4057qib7 7152 28 high high JJ cord-005453-4057qib7 7152 29 grade grade NN cord-005453-4057qib7 7152 30 free free JJ cord-005453-4057qib7 7152 31 aGvHD aGvHD . cord-005453-4057qib7 7152 32 survival survival NN cord-005453-4057qib7 7152 33 when when WRB cord-005453-4057qib7 7152 34 compared compare VBN cord-005453-4057qib7 7152 35 to to IN cord-005453-4057qib7 7152 36 the the DT cord-005453-4057qib7 7152 37 BF BF NNP cord-005453-4057qib7 7152 38 preparative preparative JJ cord-005453-4057qib7 7152 39 regimen regimen NN cord-005453-4057qib7 7152 40 . . . cord-005453-4057qib7 7153 1 Larger large JJR cord-005453-4057qib7 7153 2 studies study NNS cord-005453-4057qib7 7153 3 are be VBP cord-005453-4057qib7 7153 4 needed need VBN cord-005453-4057qib7 7153 5 to to TO cord-005453-4057qib7 7153 6 confirm confirm VB cord-005453-4057qib7 7153 7 these these DT cord-005453-4057qib7 7153 8 findings finding NNS cord-005453-4057qib7 7153 9 . . . cord-005453-4057qib7 7154 1 Disclosure disclosure NN cord-005453-4057qib7 7154 2 : : : cord-005453-4057qib7 7154 3 Nothing nothing NN cord-005453-4057qib7 7154 4 to to TO cord-005453-4057qib7 7154 5 declare declare VB cord-005453-4057qib7 7154 6 . . . cord-005453-4057qib7 7155 1 Novel novel JJ cord-005453-4057qib7 7155 2 strategy strategy NN cord-005453-4057qib7 7155 3 for for IN cord-005453-4057qib7 7155 4 haploidentical haploidentical JJ cord-005453-4057qib7 7155 5 hematopoietic hematopoietic JJ cord-005453-4057qib7 7155 6 stem stem NN cord-005453-4057qib7 7155 7 cell cell NN cord-005453-4057qib7 7155 8 transplant transplant NN cord-005453-4057qib7 7155 9 in in IN cord-005453-4057qib7 7155 10 sickle sickle NN cord-005453-4057qib7 7155 11 cell cell NN cord-005453-4057qib7 7155 12 disease disease NN cord-005453-4057qib7 7155 13 Methods method NNS cord-005453-4057qib7 7155 14 : : : cord-005453-4057qib7 7155 15 9 9 CD cord-005453-4057qib7 7155 16 consecutive consecutive JJ cord-005453-4057qib7 7155 17 patients patient NNS cord-005453-4057qib7 7155 18 suffering suffer VBG cord-005453-4057qib7 7155 19 from from IN cord-005453-4057qib7 7155 20 SCD SCD NNP cord-005453-4057qib7 7155 21 who who WP cord-005453-4057qib7 7155 22 underwent undergo VBD cord-005453-4057qib7 7155 23 HHSCT HHSCT NNP cord-005453-4057qib7 7155 24 between between IN cord-005453-4057qib7 7155 25 Jan Jan NNP cord-005453-4057qib7 7155 26 2018 2018 CD cord-005453-4057qib7 7155 27 till till IN cord-005453-4057qib7 7155 28 date date NN cord-005453-4057qib7 7155 29 were be VBD cord-005453-4057qib7 7155 30 enrolled enrol VBN cord-005453-4057qib7 7155 31 in in IN cord-005453-4057qib7 7155 32 the the DT cord-005453-4057qib7 7155 33 study study NN cord-005453-4057qib7 7155 34 . . . cord-005453-4057qib7 7156 1 All all DT cord-005453-4057qib7 7156 2 9 9 CD cord-005453-4057qib7 7156 3 underwent undergo VBD cord-005453-4057qib7 7156 4 autologous autologous JJ cord-005453-4057qib7 7156 5 backup backup NN cord-005453-4057qib7 7156 6 ( ( -LRB- cord-005453-4057qib7 7156 7 target target NN cord-005453-4057qib7 7156 8 dose>5x10 dose>5x10 NNP cord-005453-4057qib7 7156 9 6 6 CD cord-005453-4057qib7 7156 10 /kg /kg NFP cord-005453-4057qib7 7156 11 ) ) -RRB- cord-005453-4057qib7 7156 12 followed follow VBN cord-005453-4057qib7 7156 13 by by IN cord-005453-4057qib7 7156 14 pre pre JJ cord-005453-4057qib7 7156 15 - - JJ cord-005453-4057qib7 7156 16 transplant transplant JJ cord-005453-4057qib7 7156 17 immune immune JJ cord-005453-4057qib7 7156 18 suppression suppression NN cord-005453-4057qib7 7156 19 ( ( -LRB- cord-005453-4057qib7 7156 20 PTIS PTIS NNP cord-005453-4057qib7 7156 21 ) ) -RRB- cord-005453-4057qib7 7156 22 2 2 CD cord-005453-4057qib7 7156 23 cycles cycle NNS cord-005453-4057qib7 7156 24 at at IN cord-005453-4057qib7 7156 25 3 3 CD cord-005453-4057qib7 7156 26 weekly weekly JJ cord-005453-4057qib7 7156 27 intervals interval NNS cord-005453-4057qib7 7156 28 using use VBG cord-005453-4057qib7 7156 29 fludarabine fludarabine NN cord-005453-4057qib7 7156 30 @30mg @30mg NNP cord-005453-4057qib7 7156 31 / / SYM cord-005453-4057qib7 7156 32 m2 m2 NNP cord-005453-4057qib7 7156 33 / / SYM cord-005453-4057qib7 7156 34 day(D1-D5 day(d1-d5 NN cord-005453-4057qib7 7156 35 ) ) -RRB- cord-005453-4057qib7 7157 1 + + CC cord-005453-4057qib7 7157 2 cyclophosphami cyclophosphami NN cord-005453-4057qib7 7157 3 - - HYPH cord-005453-4057qib7 7157 4 de@1000mg de@1000mg VBN cord-005453-4057qib7 7157 5 / / SYM cord-005453-4057qib7 7157 6 m2 m2 NNP cord-005453-4057qib7 7157 7 / / SYM cord-005453-4057qib7 7157 8 day(D1 day(D1 NNP cord-005453-4057qib7 7157 9 ) ) -RRB- cord-005453-4057qib7 7158 1 + + CC cord-005453-4057qib7 7159 1 dexamethasone@20mg dexamethasone@20mg NNS cord-005453-4057qib7 7159 2 / / SYM cord-005453-4057qib7 7159 3 m2/ m2/ NNS cord-005453-4057qib7 7160 1 day(D1-D5 day(d1-d5 NN cord-005453-4057qib7 7160 2 ) ) -RRB- cord-005453-4057qib7 7161 1 along along IN cord-005453-4057qib7 7161 2 with with IN cord-005453-4057qib7 7161 3 hypertransfusion hypertransfusion NN cord-005453-4057qib7 7161 4 ( ( -LRB- cord-005453-4057qib7 7161 5 target target NN cord-005453-4057qib7 7161 6 Hb Hb NNP cord-005453-4057qib7 7161 7 11 11 CD cord-005453-4057qib7 7161 8 - - HYPH cord-005453-4057qib7 7161 9 13gm 13gm NN cord-005453-4057qib7 7161 10 / / SYM cord-005453-4057qib7 7161 11 dl dl NNP cord-005453-4057qib7 7161 12 ) ) -RRB- cord-005453-4057qib7 7161 13 , , , cord-005453-4057qib7 7161 14 hydroxyurea hydroxyurea NNP cord-005453-4057qib7 7161 15 ( ( -LRB- cord-005453-4057qib7 7161 16 20mg 20mg NNP cord-005453-4057qib7 7161 17 / / SYM cord-005453-4057qib7 7161 18 kg kg NN cord-005453-4057qib7 7161 19 / / SYM cord-005453-4057qib7 7161 20 day day NN cord-005453-4057qib7 7161 21 ) ) -RRB- cord-005453-4057qib7 7161 22 and and CC cord-005453-4057qib7 7161 23 azathioprine azathioprine JJ cord-005453-4057qib7 7161 24 ( ( -LRB- cord-005453-4057qib7 7161 25 2mg 2mg NNP cord-005453-4057qib7 7161 26 / / SYM cord-005453-4057qib7 7161 27 kg kg NN cord-005453-4057qib7 7161 28 / / SYM cord-005453-4057qib7 7161 29 day day NN cord-005453-4057qib7 7161 30 ) ) -RRB- cord-005453-4057qib7 7161 31 from from IN cord-005453-4057qib7 7161 32 day day NN cord-005453-4057qib7 7161 33 -60 -60 NNS cord-005453-4057qib7 7161 34 . . . cord-005453-4057qib7 7162 1 The the DT cord-005453-4057qib7 7162 2 graft graft NN cord-005453-4057qib7 7162 3 was be VBD cord-005453-4057qib7 7162 4 mobilized mobilize VBN cord-005453-4057qib7 7162 5 using use VBG cord-005453-4057qib7 7162 6 GCSF@10mcg GCSF@10mcg NNP cord-005453-4057qib7 7162 7 / / SYM cord-005453-4057qib7 7162 8 kg kg NN cord-005453-4057qib7 7162 9 / / SYM cord-005453-4057qib7 7162 10 day(D1-D5 day(d1-d5 NN cord-005453-4057qib7 7162 11 ) ) -RRB- cord-005453-4057qib7 7162 12 + + CC cord-005453-4057qib7 7162 13 Plerixafor@0.24 Plerixafor@0.24 NNP cord-005453-4057qib7 7162 14 mg mg NN cord-005453-4057qib7 7163 1 /kg /kg NFP cord-005453-4057qib7 7163 2 s/ s/ NNP cord-005453-4057qib7 7163 3 c c NN cord-005453-4057qib7 7163 4 on on IN cord-005453-4057qib7 7163 5 D5 D5 NNP cord-005453-4057qib7 7163 6 6 6 CD cord-005453-4057qib7 7163 7 - - SYM cord-005453-4057qib7 7163 8 8 8 CD cord-005453-4057qib7 7163 9 hours hour NNS cord-005453-4057qib7 7163 10 before before IN cord-005453-4057qib7 7163 11 the the DT cord-005453-4057qib7 7163 12 PBSCH PBSCH NNP cord-005453-4057qib7 7163 13 . . . cord-005453-4057qib7 7164 1 Conditioning conditioning NN cord-005453-4057qib7 7164 2 included include VBD cord-005453-4057qib7 7164 3 Thiotepa Thiotepa NNP cord-005453-4057qib7 7164 4 10mg 10mg NNP cord-005453-4057qib7 7164 5 / / SYM cord-005453-4057qib7 7164 6 kg kg NN cord-005453-4057qib7 7164 7 in in IN cord-005453-4057qib7 7164 8 two two CD cord-005453-4057qib7 7164 9 divided divide VBN cord-005453-4057qib7 7164 10 doses dose NNS cord-005453-4057qib7 7164 11 ( ( -LRB- cord-005453-4057qib7 7164 12 D-7 D-7 NNP cord-005453-4057qib7 7164 13 ) ) -RRB- cord-005453-4057qib7 7164 14 , , , cord-005453-4057qib7 7164 15 fludarabine fludarabine NNP cord-005453-4057qib7 7164 16 30mg 30mg NNP cord-005453-4057qib7 7164 17 / / SYM cord-005453-4057qib7 7164 18 m2 m2 NNP cord-005453-4057qib7 7164 19 ( ( -LRB- cord-005453-4057qib7 7164 20 D-6 D-6 NNP cord-005453-4057qib7 7164 21 to to IN cord-005453-4057qib7 7164 22 D-2 D-2 NNP cord-005453-4057qib7 7164 23 ) ) -RRB- cord-005453-4057qib7 7164 24 , , , cord-005453-4057qib7 7164 25 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 7164 26 14.5 14.5 CD cord-005453-4057qib7 7164 27 mg mg NNP cord-005453-4057qib7 7164 28 / / SYM cord-005453-4057qib7 7164 29 kg kg NNP cord-005453-4057qib7 7164 30 ( ( -LRB- cord-005453-4057qib7 7164 31 D-5 D-5 NNP cord-005453-4057qib7 7164 32 , , , cord-005453-4057qib7 7164 33 D-4 D-4 NNP cord-005453-4057qib7 7164 34 ) ) -RRB- cord-005453-4057qib7 7164 35 , , , cord-005453-4057qib7 7164 36 TBI TBI NNP cord-005453-4057qib7 7164 37 2Gy 2gy NN cord-005453-4057qib7 7164 38 with with IN cord-005453-4057qib7 7164 39 thymic thymic JJ cord-005453-4057qib7 7164 40 shielding shielding NN cord-005453-4057qib7 7164 41 ( ( -LRB- cord-005453-4057qib7 7165 1 D-1 D-1 NNP cord-005453-4057qib7 7165 2 ) ) -RRB- cord-005453-4057qib7 7165 3 , , , cord-005453-4057qib7 7165 4 rATG rATG NNP cord-005453-4057qib7 7165 5 ( ( -LRB- cord-005453-4057qib7 7165 6 Genzyme Genzyme NNP cord-005453-4057qib7 7165 7 Thymoglobulin Thymoglobulin NNP cord-005453-4057qib7 7165 8 1.5 1.5 CD cord-005453-4057qib7 7165 9 mg mg NNP cord-005453-4057qib7 7165 10 / / SYM cord-005453-4057qib7 7165 11 kg kg NNP cord-005453-4057qib7 7165 12 ( ( -LRB- cord-005453-4057qib7 7165 13 D-9 D-9 NNP cord-005453-4057qib7 7165 14 to to IN cord-005453-4057qib7 7165 15 D-7 D-7 NNP cord-005453-4057qib7 7165 16 ) ) -RRB- cord-005453-4057qib7 7165 17 . . . cord-005453-4057qib7 7166 1 GVHD GVHD NNP cord-005453-4057qib7 7166 2 prophylaxis prophylaxis NN cord-005453-4057qib7 7166 3 included include VBD cord-005453-4057qib7 7166 4 PTCy PTCy NNS cord-005453-4057qib7 7167 1 50 50 CD cord-005453-4057qib7 7167 2 mg mg NNP cord-005453-4057qib7 7167 3 / / SYM cord-005453-4057qib7 7167 4 kg kg NNP cord-005453-4057qib7 7167 5 / / SYM cord-005453-4057qib7 7167 6 day day NN cord-005453-4057qib7 7167 7 on on IN cord-005453-4057qib7 7167 8 D3 D3 NNP cord-005453-4057qib7 7167 9 and and CC cord-005453-4057qib7 7167 10 4 4 CD cord-005453-4057qib7 7168 1 , , , cord-005453-4057qib7 7168 2 sirolimus sirolimus NNP cord-005453-4057qib7 7168 3 ( ( -LRB- cord-005453-4057qib7 7168 4 target target NN cord-005453-4057qib7 7168 5 levels level NNS cord-005453-4057qib7 7168 6 10 10 CD cord-005453-4057qib7 7168 7 - - HYPH cord-005453-4057qib7 7168 8 15ng 15ng NN cord-005453-4057qib7 7168 9 / / SYM cord-005453-4057qib7 7168 10 ml ml NN cord-005453-4057qib7 7168 11 ) ) -RRB- cord-005453-4057qib7 7168 12 ( ( -LRB- cord-005453-4057qib7 7168 13 till till IN cord-005453-4057qib7 7168 14 9 9 CD cord-005453-4057qib7 7168 15 - - SYM cord-005453-4057qib7 7168 16 12 12 CD cord-005453-4057qib7 7168 17 months month NNS cord-005453-4057qib7 7168 18 post post NN cord-005453-4057qib7 7168 19 HSCT HSCT NNP cord-005453-4057qib7 7168 20 ) ) -RRB- cord-005453-4057qib7 7168 21 and and CC cord-005453-4057qib7 7168 22 MMF mmf NN cord-005453-4057qib7 7168 23 ( ( -LRB- cord-005453-4057qib7 7168 24 till till IN cord-005453-4057qib7 7168 25 D35 D35 NNP cord-005453-4057qib7 7168 26 ) ) -RRB- cord-005453-4057qib7 7169 1 starting start VBG cord-005453-4057qib7 7169 2 from from IN cord-005453-4057qib7 7169 3 D5 D5 NNP cord-005453-4057qib7 7169 4 . . . cord-005453-4057qib7 7170 1 Results result NNS cord-005453-4057qib7 7170 2 : : : cord-005453-4057qib7 7171 1 The the DT cord-005453-4057qib7 7171 2 median median JJ cord-005453-4057qib7 7171 3 age age NN cord-005453-4057qib7 7171 4 of of IN cord-005453-4057qib7 7171 5 patient patient NN cord-005453-4057qib7 7171 6 's 's POS cord-005453-4057qib7 7171 7 was be VBD cord-005453-4057qib7 7171 8 7 7 CD cord-005453-4057qib7 7171 9 years year NNS cord-005453-4057qib7 7172 1 ( ( -LRB- cord-005453-4057qib7 7172 2 range range NNP cord-005453-4057qib7 7172 3 3 3 CD cord-005453-4057qib7 7172 4 - - SYM cord-005453-4057qib7 7172 5 22 22 CD cord-005453-4057qib7 7172 6 years year NNS cord-005453-4057qib7 7172 7 ) ) -RRB- cord-005453-4057qib7 7172 8 . . . cord-005453-4057qib7 7173 1 Before before IN cord-005453-4057qib7 7173 2 transplantation transplantation NN cord-005453-4057qib7 7173 3 all all DT cord-005453-4057qib7 7173 4 patients patient NNS cord-005453-4057qib7 7173 5 had have VBD cord-005453-4057qib7 7173 6 repeated repeat VBN cord-005453-4057qib7 7173 7 episodes episode NNS cord-005453-4057qib7 7173 8 of of IN cord-005453-4057qib7 7173 9 one one CD cord-005453-4057qib7 7173 10 or or CC cord-005453-4057qib7 7173 11 other other JJ cord-005453-4057qib7 7173 12 complication complication NN cord-005453-4057qib7 7173 13 warranting warrant VBG cord-005453-4057qib7 7173 14 a a DT cord-005453-4057qib7 7173 15 transplant transplant NN cord-005453-4057qib7 7173 16 , , , cord-005453-4057qib7 7173 17 non non JJ cord-005453-4057qib7 7173 18 - - JJ cord-005453-4057qib7 7173 19 responsive responsive JJ cord-005453-4057qib7 7173 20 to to IN cord-005453-4057qib7 7173 21 hydroxyurea hydroxyurea NNP cord-005453-4057qib7 7173 22 . . . cord-005453-4057qib7 7174 1 Six six CD cord-005453-4057qib7 7174 2 had have VBD cord-005453-4057qib7 7174 3 maternal maternal JJ cord-005453-4057qib7 7174 4 donors donor NNS cord-005453-4057qib7 7174 5 , , , cord-005453-4057qib7 7174 6 2 2 CD cord-005453-4057qib7 7174 7 paternal paternal JJ cord-005453-4057qib7 7174 8 and and CC cord-005453-4057qib7 7174 9 1 1 CD cord-005453-4057qib7 7174 10 sibling sibling NN cord-005453-4057qib7 7174 11 . . . cord-005453-4057qib7 7175 1 Median median JJ cord-005453-4057qib7 7175 2 age age NN cord-005453-4057qib7 7175 3 of of IN cord-005453-4057qib7 7175 4 the the DT cord-005453-4057qib7 7175 5 donor donor NN cord-005453-4057qib7 7175 6 was be VBD cord-005453-4057qib7 7175 7 41 41 CD cord-005453-4057qib7 7175 8 years year NNS cord-005453-4057qib7 7176 1 ( ( -LRB- cord-005453-4057qib7 7176 2 range range NNP cord-005453-4057qib7 7176 3 19 19 CD cord-005453-4057qib7 7176 4 - - SYM cord-005453-4057qib7 7176 5 51 51 CD cord-005453-4057qib7 7176 6 years year NNS cord-005453-4057qib7 7176 7 ) ) -RRB- cord-005453-4057qib7 7176 8 . . . cord-005453-4057qib7 7177 1 All all DT cord-005453-4057qib7 7177 2 were be VBD cord-005453-4057qib7 7177 3 DSA DSA NNP cord-005453-4057qib7 7177 4 negative negative JJ cord-005453-4057qib7 7177 5 with with IN cord-005453-4057qib7 7177 6 a a DT cord-005453-4057qib7 7177 7 cutoff cutoff NN cord-005453-4057qib7 7177 8 MFI MFI NNP cord-005453-4057qib7 7177 9 of of IN cord-005453-4057qib7 7177 10 > > XX cord-005453-4057qib7 7177 11 2000 2000 CD cord-005453-4057qib7 7177 12 IU IU NNP cord-005453-4057qib7 7177 13 . . . cord-005453-4057qib7 7178 1 All all DT cord-005453-4057qib7 7178 2 patients patient NNS cord-005453-4057qib7 7178 3 received receive VBD cord-005453-4057qib7 7178 4 10x10 10x10 CD cord-005453-4057qib7 7178 5 6 6 CD cord-005453-4057qib7 7178 6 /kg /kg . cord-005453-4057qib7 7178 7 CD34 CD34 NNP cord-005453-4057qib7 7178 8 cells cell NNS cord-005453-4057qib7 7178 9 irrespective irrespective RB cord-005453-4057qib7 7178 10 of of IN cord-005453-4057qib7 7178 11 harvested harvest VBN cord-005453-4057qib7 7178 12 dose dose NN cord-005453-4057qib7 7178 13 which which WDT cord-005453-4057qib7 7178 14 ranged range VBD cord-005453-4057qib7 7178 15 from from IN cord-005453-4057qib7 7178 16 ( ( -LRB- cord-005453-4057qib7 7178 17 10.13 10.13 CD cord-005453-4057qib7 7178 18 - - SYM cord-005453-4057qib7 7178 19 34.82 34.82 CD cord-005453-4057qib7 7178 20 x10 x10 CD cord-005453-4057qib7 7178 21 6 6 CD cord-005453-4057qib7 7178 22 /kg /kg . cord-005453-4057qib7 7178 23 ) ) -RRB- cord-005453-4057qib7 7178 24 . . . cord-005453-4057qib7 7179 1 Median median JJ cord-005453-4057qib7 7179 2 CD3 CD3 NNP cord-005453-4057qib7 7179 3 dose dose NN cord-005453-4057qib7 7179 4 was be VBD cord-005453-4057qib7 7179 5 16.59 16.59 CD cord-005453-4057qib7 7179 6 x10 x10 CD cord-005453-4057qib7 7179 7 7 7 CD cord-005453-4057qib7 7180 1 /kg /kg NFP cord-005453-4057qib7 7180 2 ( ( -LRB- cord-005453-4057qib7 7180 3 range range NN cord-005453-4057qib7 7180 4 10.44 10.44 CD cord-005453-4057qib7 7180 5 - - HYPH cord-005453-4057qib7 7180 6 41.9 41.9 CD cord-005453-4057qib7 7180 7 x10 x10 CD cord-005453-4057qib7 7180 8 7 7 CD cord-005453-4057qib7 7180 9 /kg /kg . cord-005453-4057qib7 7180 10 ) ) -RRB- cord-005453-4057qib7 7180 11 . . . cord-005453-4057qib7 7181 1 All all DT cord-005453-4057qib7 7181 2 patients patient NNS cord-005453-4057qib7 7181 3 engrafted engraft VBN cord-005453-4057qib7 7181 4 with with IN cord-005453-4057qib7 7181 5 median median JJ cord-005453-4057qib7 7181 6 time time NN cord-005453-4057qib7 7181 7 to to IN cord-005453-4057qib7 7181 8 neutrophil neutrophil NN cord-005453-4057qib7 7181 9 engraftment engraftment NN cord-005453-4057qib7 7181 10 13 13 CD cord-005453-4057qib7 7181 11 days day NNS cord-005453-4057qib7 7181 12 ( ( -LRB- cord-005453-4057qib7 7181 13 range range VBP cord-005453-4057qib7 7181 14 12 12 CD cord-005453-4057qib7 7181 15 - - SYM cord-005453-4057qib7 7181 16 15 15 CD cord-005453-4057qib7 7181 17 days day NNS cord-005453-4057qib7 7181 18 ) ) -RRB- cord-005453-4057qib7 7181 19 and and CC cord-005453-4057qib7 7181 20 median median JJ cord-005453-4057qib7 7181 21 time time NN cord-005453-4057qib7 7181 22 to to IN cord-005453-4057qib7 7181 23 platelet platelet NN cord-005453-4057qib7 7181 24 engraftment engraftment NN cord-005453-4057qib7 7181 25 13 13 CD cord-005453-4057qib7 7181 26 days day NNS cord-005453-4057qib7 7181 27 ( ( -LRB- cord-005453-4057qib7 7181 28 range range VBP cord-005453-4057qib7 7181 29 11 11 CD cord-005453-4057qib7 7181 30 - - SYM cord-005453-4057qib7 7181 31 16 16 CD cord-005453-4057qib7 7181 32 days day NNS cord-005453-4057qib7 7181 33 ) ) -RRB- cord-005453-4057qib7 7181 34 . . . cord-005453-4057qib7 7182 1 Median median JJ cord-005453-4057qib7 7182 2 duration duration NN cord-005453-4057qib7 7182 3 of of IN cord-005453-4057qib7 7182 4 hospital hospital NN cord-005453-4057qib7 7182 5 stay stay NN cord-005453-4057qib7 7182 6 was be VBD cord-005453-4057qib7 7182 7 30 30 CD cord-005453-4057qib7 7182 8 days day NNS cord-005453-4057qib7 7182 9 ( ( -LRB- cord-005453-4057qib7 7182 10 range range VBP cord-005453-4057qib7 7182 11 24 24 CD cord-005453-4057qib7 7182 12 - - SYM cord-005453-4057qib7 7182 13 35 35 CD cord-005453-4057qib7 7182 14 days day NNS cord-005453-4057qib7 7182 15 ) ) -RRB- cord-005453-4057qib7 7182 16 . . . cord-005453-4057qib7 7183 1 One one CD cord-005453-4057qib7 7183 2 patient patient NN cord-005453-4057qib7 7183 3 had have VBD cord-005453-4057qib7 7183 4 cytokine cytokine NN cord-005453-4057qib7 7183 5 release release NN cord-005453-4057qib7 7183 6 syndrome syndrome NN cord-005453-4057qib7 7183 7 needing need VBG cord-005453-4057qib7 7183 8 tocilizumab tocilizumab NNP cord-005453-4057qib7 7183 9 . . . cord-005453-4057qib7 7184 1 Five five CD cord-005453-4057qib7 7184 2 had have VBD cord-005453-4057qib7 7184 3 engraftment engraftment NN cord-005453-4057qib7 7184 4 syndrome syndrome NN cord-005453-4057qib7 7184 5 treated treat VBN cord-005453-4057qib7 7184 6 with with IN cord-005453-4057qib7 7184 7 short short JJ cord-005453-4057qib7 7184 8 course course NN cord-005453-4057qib7 7184 9 of of IN cord-005453-4057qib7 7184 10 steroids steroid NNS cord-005453-4057qib7 7184 11 . . . cord-005453-4057qib7 7185 1 Two two CD cord-005453-4057qib7 7185 2 had have VBD cord-005453-4057qib7 7185 3 CMV CMV NNP cord-005453-4057qib7 7185 4 reactivation reactivation NN cord-005453-4057qib7 7185 5 needing need VBG cord-005453-4057qib7 7185 6 treatment treatment NN cord-005453-4057qib7 7185 7 with with IN cord-005453-4057qib7 7185 8 ganciclovir ganciclovir NNP cord-005453-4057qib7 7185 9 / / SYM cord-005453-4057qib7 7185 10 valganciclovir valganciclovir NNP cord-005453-4057qib7 7185 11 . . . cord-005453-4057qib7 7186 1 Acute acute JJ cord-005453-4057qib7 7186 2 GVHD GVHD NNP cord-005453-4057qib7 7186 3 grade grade NN cord-005453-4057qib7 7186 4 II II NNP cord-005453-4057qib7 7186 5 was be VBD cord-005453-4057qib7 7186 6 seen see VBN cord-005453-4057qib7 7186 7 in in IN cord-005453-4057qib7 7186 8 one one CD cord-005453-4057qib7 7186 9 patient patient NN cord-005453-4057qib7 7186 10 . . . cord-005453-4057qib7 7187 1 Till till IN cord-005453-4057qib7 7187 2 date date NN cord-005453-4057qib7 7187 3 of of IN cord-005453-4057qib7 7187 4 analysis analysis NN cord-005453-4057qib7 7187 5 none none NN cord-005453-4057qib7 7187 6 had have VBD cord-005453-4057qib7 7187 7 features feature NNS cord-005453-4057qib7 7187 8 compatible compatible JJ cord-005453-4057qib7 7187 9 with with IN cord-005453-4057qib7 7187 10 chronic chronic JJ cord-005453-4057qib7 7187 11 GVHD GVHD NNP cord-005453-4057qib7 7187 12 . . . cord-005453-4057qib7 7188 1 Of of IN cord-005453-4057qib7 7188 2 the the DT cord-005453-4057qib7 7188 3 9 9 CD cord-005453-4057qib7 7188 4 patients patient NNS cord-005453-4057qib7 7188 5 , , , cord-005453-4057qib7 7188 6 8 8 CD cord-005453-4057qib7 7188 7 are be VBP cord-005453-4057qib7 7188 8 alive alive JJ cord-005453-4057qib7 7188 9 without without IN cord-005453-4057qib7 7188 10 sickle sickle NN cord-005453-4057qib7 7188 11 cell cell NN cord-005453-4057qib7 7188 12 disease disease NN cord-005453-4057qib7 7188 13 with with IN cord-005453-4057qib7 7188 14 Lansky/ Lansky/ NNP cord-005453-4057qib7 7188 15 Karnofsky Karnofsky NNP cord-005453-4057qib7 7188 16 scores score NNS cord-005453-4057qib7 7188 17 of of IN cord-005453-4057qib7 7188 18 100 100 CD cord-005453-4057qib7 7188 19 . . . cord-005453-4057qib7 7189 1 At at IN cord-005453-4057qib7 7189 2 median median NN cord-005453-4057qib7 7189 3 follow follow VB cord-005453-4057qib7 7189 4 up up IN cord-005453-4057qib7 7189 5 of of IN cord-005453-4057qib7 7189 6 164 164 CD cord-005453-4057qib7 7189 7 days day NNS cord-005453-4057qib7 7189 8 ( ( -LRB- cord-005453-4057qib7 7189 9 range range VBP cord-005453-4057qib7 7189 10 61 61 CD cord-005453-4057qib7 7189 11 - - SYM cord-005453-4057qib7 7189 12 271 271 CD cord-005453-4057qib7 7189 13 ) ) -RRB- cord-005453-4057qib7 7190 1 the the DT cord-005453-4057qib7 7190 2 probabilities probability NNS cord-005453-4057qib7 7190 3 of of IN cord-005453-4057qib7 7190 4 survival survival NN cord-005453-4057qib7 7190 5 , , , cord-005453-4057qib7 7190 6 SCA SCA NNP cord-005453-4057qib7 7190 7 - - HYPH cord-005453-4057qib7 7190 8 free free JJ cord-005453-4057qib7 7190 9 survival survival NN cord-005453-4057qib7 7190 10 , , , cord-005453-4057qib7 7190 11 and and CC cord-005453-4057qib7 7190 12 transplant transplant NN cord-005453-4057qib7 7190 13 - - HYPH cord-005453-4057qib7 7190 14 related relate VBN cord-005453-4057qib7 7190 15 mortality mortality NN cord-005453-4057qib7 7190 16 after after IN cord-005453-4057qib7 7190 17 transplant transplant NN cord-005453-4057qib7 7190 18 were be VBD cord-005453-4057qib7 7190 19 88.9 88.9 CD cord-005453-4057qib7 7190 20 % % NN cord-005453-4057qib7 7190 21 , , , cord-005453-4057qib7 7190 22 88.9 88.9 CD cord-005453-4057qib7 7190 23 % % NN cord-005453-4057qib7 7190 24 , , , cord-005453-4057qib7 7190 25 and and CC cord-005453-4057qib7 7190 26 11.1 11.1 CD cord-005453-4057qib7 7190 27 % % NN cord-005453-4057qib7 7190 28 , , , cord-005453-4057qib7 7190 29 respectively respectively RB cord-005453-4057qib7 7190 30 . . . cord-005453-4057qib7 7191 1 One one CD cord-005453-4057qib7 7191 2 patient patient NN cord-005453-4057qib7 7191 3 died die VBD cord-005453-4057qib7 7191 4 due due IN cord-005453-4057qib7 7191 5 to to IN cord-005453-4057qib7 7191 6 MDR MDR NNP cord-005453-4057qib7 7191 7 Klebsiella Klebsiella NNP cord-005453-4057qib7 7191 8 sepsis sepsis NN cord-005453-4057qib7 7191 9 after after IN cord-005453-4057qib7 7191 10 being be VBG cord-005453-4057qib7 7191 11 discharged discharge VBN cord-005453-4057qib7 7191 12 initially initially RB cord-005453-4057qib7 7191 13 while while IN cord-005453-4057qib7 7191 14 he -PRON- PRP cord-005453-4057qib7 7191 15 was be VBD cord-005453-4057qib7 7191 16 receiving receive VBG cord-005453-4057qib7 7191 17 IV IV NNP cord-005453-4057qib7 7191 18 ganciclovir ganciclovir NN cord-005453-4057qib7 7191 19 on on IN cord-005453-4057qib7 7191 20 day day NN cord-005453-4057qib7 7191 21 care care NN cord-005453-4057qib7 7191 22 basis basis NN cord-005453-4057qib7 7191 23 . . . cord-005453-4057qib7 7192 1 He -PRON- PRP cord-005453-4057qib7 7192 2 had have VBD cord-005453-4057qib7 7192 3 full full JJ cord-005453-4057qib7 7192 4 donor donor NN cord-005453-4057qib7 7192 5 chimerism chimerism NN cord-005453-4057qib7 7192 6 . . . cord-005453-4057qib7 7193 1 None none NN cord-005453-4057qib7 7193 2 of of IN cord-005453-4057qib7 7193 3 the the DT cord-005453-4057qib7 7193 4 patient patient NN cord-005453-4057qib7 7193 5 had have VBD cord-005453-4057qib7 7193 6 primary primary JJ cord-005453-4057qib7 7193 7 or or CC cord-005453-4057qib7 7193 8 secondary secondary JJ cord-005453-4057qib7 7193 9 graft graft NN cord-005453-4057qib7 7193 10 failure failure NN cord-005453-4057qib7 7193 11 . . . cord-005453-4057qib7 7194 1 Conclusions conclusion NNS cord-005453-4057qib7 7194 2 : : : cord-005453-4057qib7 7195 1 Pre pre JJ cord-005453-4057qib7 7195 2 - - JJ cord-005453-4057qib7 7195 3 transplant transplant JJ cord-005453-4057qib7 7195 4 immune immune JJ cord-005453-4057qib7 7195 5 suppression suppression NN cord-005453-4057qib7 7195 6 and and CC cord-005453-4057qib7 7195 7 upfront upfront JJ cord-005453-4057qib7 7195 8 use use NN cord-005453-4057qib7 7195 9 of of IN cord-005453-4057qib7 7195 10 plerixafor plerixafor NN cord-005453-4057qib7 7195 11 for for IN cord-005453-4057qib7 7195 12 graft graft NN cord-005453-4057qib7 7195 13 mobilization mobilization NN cord-005453-4057qib7 7195 14 decreases decrease VBZ cord-005453-4057qib7 7195 15 the the DT cord-005453-4057qib7 7195 16 risk risk NN cord-005453-4057qib7 7195 17 of of IN cord-005453-4057qib7 7195 18 graft graft NN cord-005453-4057qib7 7195 19 failure failure NN cord-005453-4057qib7 7195 20 and and CC cord-005453-4057qib7 7195 21 graft graft NN cord-005453-4057qib7 7195 22 versus versus IN cord-005453-4057qib7 7195 23 host host NN cord-005453-4057qib7 7195 24 disease disease NN cord-005453-4057qib7 7195 25 leading lead VBG cord-005453-4057qib7 7195 26 to to IN cord-005453-4057qib7 7195 27 overall overall JJ cord-005453-4057qib7 7195 28 better well JJR cord-005453-4057qib7 7195 29 survival survival NN cord-005453-4057qib7 7195 30 in in IN cord-005453-4057qib7 7195 31 HHSCT HHSCT NNP cord-005453-4057qib7 7195 32 for for IN cord-005453-4057qib7 7195 33 sickle sickle NN cord-005453-4057qib7 7195 34 cell cell NN cord-005453-4057qib7 7195 35 disease disease NN cord-005453-4057qib7 7195 36 . . . cord-005453-4057qib7 7196 1 Disclosure disclosure NN cord-005453-4057qib7 7196 2 : : : cord-005453-4057qib7 7196 3 None none NN cord-005453-4057qib7 7196 4 . . . cord-005453-4057qib7 7197 1 Combined combine VBN cord-005453-4057qib7 7197 2 haematopoietic haematopoietic JJ cord-005453-4057qib7 7197 3 stem stem NN cord-005453-4057qib7 7197 4 cell cell NN cord-005453-4057qib7 7197 5 transplant transplant NN cord-005453-4057qib7 7197 6 and and CC cord-005453-4057qib7 7197 7 enzyme enzyme NN cord-005453-4057qib7 7197 8 replacement replacement NN cord-005453-4057qib7 7197 9 therapy therapy NN cord-005453-4057qib7 7197 10 in in IN cord-005453-4057qib7 7197 11 wolman wolman NNP cord-005453-4057qib7 7197 12 disease disease NN cord-005453-4057qib7 7197 13 : : : cord-005453-4057qib7 7198 1 Outcomes outcome NNS cord-005453-4057qib7 7198 2 and and CC cord-005453-4057qib7 7198 3 challenges challenge VBZ cord-005453-4057qib7 7198 4 Jane Jane NNP cord-005453-4057qib7 7198 5 Kinsella Kinsella NNP cord-005453-4057qib7 7198 6 1 1 CD cord-005453-4057qib7 7198 7 , , , cord-005453-4057qib7 7198 8 Denise Denise NNP cord-005453-4057qib7 7198 9 Bonney Bonney NNP cord-005453-4057qib7 7198 10 1 1 CD cord-005453-4057qib7 7198 11 , , , cord-005453-4057qib7 7198 12 Helen Helen NNP cord-005453-4057qib7 7198 13 Campbell Campbell NNP cord-005453-4057qib7 7198 14 1 1 CD cord-005453-4057qib7 7198 15 , , , cord-005453-4057qib7 7198 16 Robert Robert NNP cord-005453-4057qib7 7198 17 Wynn Wynn NNP cord-005453-4057qib7 7198 18 1 1 CD cord-005453-4057qib7 7199 1 , , , cord-005453-4057qib7 7199 2 Simon Simon NNP cord-005453-4057qib7 7199 3 Jones Jones NNP cord-005453-4057qib7 7199 4 1 1 CD cord-005453-4057qib7 7199 5 Background Background NNP cord-005453-4057qib7 7199 6 : : : cord-005453-4057qib7 7200 1 Infantile infantile JJ cord-005453-4057qib7 7200 2 lysosomal lysosomal JJ cord-005453-4057qib7 7200 3 acid acid NN cord-005453-4057qib7 7200 4 lipase lipase NN cord-005453-4057qib7 7200 5 deficiencymore deficiencymore NN cord-005453-4057qib7 7200 6 commonly commonly RB cord-005453-4057qib7 7200 7 known know VBN cord-005453-4057qib7 7200 8 as as IN cord-005453-4057qib7 7200 9 Wolman Wolman NNP cord-005453-4057qib7 7200 10 disease disease NN cord-005453-4057qib7 7200 11 -is -i VBZ cord-005453-4057qib7 7200 12 an an DT cord-005453-4057qib7 7200 13 autosomal autosomal JJ cord-005453-4057qib7 7200 14 recessive recessive JJ cord-005453-4057qib7 7200 15 lysosomal lysosomal JJ cord-005453-4057qib7 7200 16 storage storage NN cord-005453-4057qib7 7200 17 disease disease NN cord-005453-4057qib7 7200 18 , , , cord-005453-4057qib7 7200 19 characterised characterise VBN cord-005453-4057qib7 7200 20 by by IN cord-005453-4057qib7 7200 21 storage storage NN cord-005453-4057qib7 7200 22 of of IN cord-005453-4057qib7 7200 23 cholesterol cholesterol NN cord-005453-4057qib7 7200 24 esters ester NNS cord-005453-4057qib7 7200 25 in in IN cord-005453-4057qib7 7200 26 the the DT cord-005453-4057qib7 7200 27 liver liver NN cord-005453-4057qib7 7200 28 , , , cord-005453-4057qib7 7200 29 spleen spleen NN cord-005453-4057qib7 7200 30 and and CC cord-005453-4057qib7 7200 31 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 7200 32 tract tract NN cord-005453-4057qib7 7200 33 . . . cord-005453-4057qib7 7201 1 These these DT cord-005453-4057qib7 7201 2 children child NNS cord-005453-4057qib7 7201 3 present present JJ cord-005453-4057qib7 7201 4 under under IN cord-005453-4057qib7 7201 5 the the DT cord-005453-4057qib7 7201 6 age age NN cord-005453-4057qib7 7201 7 of of IN cord-005453-4057qib7 7201 8 6 6 CD cord-005453-4057qib7 7201 9 months month NNS cord-005453-4057qib7 7201 10 and and CC cord-005453-4057qib7 7201 11 traditionally traditionally RB cord-005453-4057qib7 7201 12 had have VBD cord-005453-4057qib7 7201 13 a a DT cord-005453-4057qib7 7201 14 poor poor JJ cord-005453-4057qib7 7201 15 prognosis prognosis NN cord-005453-4057qib7 7201 16 , , , cord-005453-4057qib7 7201 17 with with IN cord-005453-4057qib7 7201 18 almost almost RB cord-005453-4057qib7 7201 19 all all DT cord-005453-4057qib7 7201 20 being be VBG cord-005453-4057qib7 7201 21 dead dead JJ cord-005453-4057qib7 7201 22 by by IN cord-005453-4057qib7 7201 23 the the DT cord-005453-4057qib7 7201 24 age age NN cord-005453-4057qib7 7201 25 of of IN cord-005453-4057qib7 7201 26 12 12 CD cord-005453-4057qib7 7201 27 months month NNS cord-005453-4057qib7 7201 28 . . . cord-005453-4057qib7 7202 1 Bone bone NN cord-005453-4057qib7 7202 2 marrow marrow NN cord-005453-4057qib7 7202 3 transplant transplant NN cord-005453-4057qib7 7202 4 has have VBZ cord-005453-4057qib7 7202 5 been be VBN cord-005453-4057qib7 7202 6 used use VBN cord-005453-4057qib7 7202 7 to to TO cord-005453-4057qib7 7202 8 correct correct VB cord-005453-4057qib7 7202 9 disease disease NN cord-005453-4057qib7 7202 10 manifestations manifestation NNS cord-005453-4057qib7 7202 11 , , , cord-005453-4057qib7 7202 12 but but CC cord-005453-4057qib7 7202 13 limited limit VBN cord-005453-4057qib7 7202 14 by by IN cord-005453-4057qib7 7202 15 high high JJ cord-005453-4057qib7 7202 16 procedure procedure NN cord-005453-4057qib7 7202 17 - - HYPH cord-005453-4057qib7 7202 18 related relate VBN cord-005453-4057qib7 7202 19 mortality mortality NN cord-005453-4057qib7 7202 20 with with IN cord-005453-4057qib7 7202 21 the the DT cord-005453-4057qib7 7202 22 significant significant JJ cord-005453-4057qib7 7202 23 co co NNS cord-005453-4057qib7 7202 24 - - NNS cord-005453-4057qib7 7202 25 morbidities morbidity NNS cord-005453-4057qib7 7202 26 . . . cord-005453-4057qib7 7203 1 The the DT cord-005453-4057qib7 7203 2 survival survival NN cord-005453-4057qib7 7203 3 has have VBZ cord-005453-4057qib7 7203 4 changed change VBN cord-005453-4057qib7 7203 5 over over IN cord-005453-4057qib7 7203 6 the the DT cord-005453-4057qib7 7203 7 past past JJ cord-005453-4057qib7 7203 8 few few JJ cord-005453-4057qib7 7203 9 years year NNS cord-005453-4057qib7 7203 10 due due JJ cord-005453-4057qib7 7203 11 to to IN cord-005453-4057qib7 7203 12 pharmacological pharmacological JJ cord-005453-4057qib7 7203 13 enzyme enzyme NN cord-005453-4057qib7 7203 14 replacement replacement NN cord-005453-4057qib7 7203 15 therapy therapy NN cord-005453-4057qib7 7203 16 but but CC cord-005453-4057qib7 7203 17 still still RB cord-005453-4057qib7 7203 18 presents present VBZ cord-005453-4057qib7 7203 19 challenges challenge NNS cord-005453-4057qib7 7203 20 for for IN cord-005453-4057qib7 7203 21 these these DT cord-005453-4057qib7 7203 22 patients patient NNS cord-005453-4057qib7 7203 23 and and CC cord-005453-4057qib7 7203 24 their -PRON- PRP$ cord-005453-4057qib7 7203 25 clinicians clinician NNS cord-005453-4057qib7 7203 26 . . . cord-005453-4057qib7 7204 1 In in IN cord-005453-4057qib7 7204 2 these these DT cord-005453-4057qib7 7204 3 children child NNS cord-005453-4057qib7 7204 4 haematopoietic haematopoietic JJ cord-005453-4057qib7 7204 5 stem stem NN cord-005453-4057qib7 7204 6 cell cell NN cord-005453-4057qib7 7204 7 transplant transplant NN cord-005453-4057qib7 7204 8 we -PRON- PRP cord-005453-4057qib7 7204 9 have have VBP cord-005453-4057qib7 7204 10 offered offer VBN cord-005453-4057qib7 7204 11 BMT BMT NNP cord-005453-4057qib7 7204 12 with with IN cord-005453-4057qib7 7204 13 enzyme enzyme NN cord-005453-4057qib7 7204 14 replacement replacement NN cord-005453-4057qib7 7204 15 therapy therapy NN cord-005453-4057qib7 7204 16 , , , cord-005453-4057qib7 7204 17 in in IN cord-005453-4057qib7 7204 18 certain certain JJ cord-005453-4057qib7 7204 19 specific specific JJ cord-005453-4057qib7 7204 20 circumstances circumstance NNS cord-005453-4057qib7 7204 21 . . . cord-005453-4057qib7 7205 1 Methods method NNS cord-005453-4057qib7 7205 2 : : : cord-005453-4057qib7 7205 3 Four four CD cord-005453-4057qib7 7205 4 children child NNS cord-005453-4057qib7 7205 5 with with IN cord-005453-4057qib7 7205 6 Wolman Wolman NNP cord-005453-4057qib7 7205 7 disease disease NN cord-005453-4057qib7 7205 8 being be VBG cord-005453-4057qib7 7205 9 treated treat VBN cord-005453-4057qib7 7205 10 with with IN cord-005453-4057qib7 7205 11 enzyme enzyme NN cord-005453-4057qib7 7205 12 replacement replacement NN cord-005453-4057qib7 7205 13 therapy therapy NN cord-005453-4057qib7 7205 14 , , , cord-005453-4057qib7 7205 15 limited limit VBN cord-005453-4057qib7 7205 16 by by IN cord-005453-4057qib7 7205 17 alloantibody alloantibody NN cord-005453-4057qib7 7205 18 , , , cord-005453-4057qib7 7205 19 or or CC cord-005453-4057qib7 7205 20 poor poor JJ cord-005453-4057qib7 7205 21 venous venous JJ cord-005453-4057qib7 7205 22 access access NN cord-005453-4057qib7 7205 23 , , , cord-005453-4057qib7 7205 24 received receive VBD cord-005453-4057qib7 7205 25 treosulfan treosulfan NNP cord-005453-4057qib7 7205 26 - - HYPH cord-005453-4057qib7 7205 27 based base VBN cord-005453-4057qib7 7205 28 , , , cord-005453-4057qib7 7205 29 myeloablative myeloablative NNP cord-005453-4057qib7 7205 30 conditioning conditioning NN cord-005453-4057qib7 7205 31 with with IN cord-005453-4057qib7 7205 32 serotherapy serotherapy NN cord-005453-4057qib7 7205 33 followed follow VBN cord-005453-4057qib7 7205 34 by by IN cord-005453-4057qib7 7205 35 a a DT cord-005453-4057qib7 7205 36 matched match VBN cord-005453-4057qib7 7205 37 haematopoietic haematopoietic JJ cord-005453-4057qib7 7205 38 stem stem NN cord-005453-4057qib7 7205 39 cell cell NN cord-005453-4057qib7 7205 40 transplant transplant NN cord-005453-4057qib7 7205 41 : : : cord-005453-4057qib7 7205 42 two two CD cord-005453-4057qib7 7205 43 family family NN cord-005453-4057qib7 7205 44 donors donor NNS cord-005453-4057qib7 7205 45 , , , cord-005453-4057qib7 7205 46 one one CD cord-005453-4057qib7 7205 47 sibling sibling NN cord-005453-4057qib7 7205 48 donor donor NN cord-005453-4057qib7 7205 49 and and CC cord-005453-4057qib7 7205 50 one one CD cord-005453-4057qib7 7205 51 unrelated unrelated JJ cord-005453-4057qib7 7205 52 donor donor NN cord-005453-4057qib7 7205 53 . . . cord-005453-4057qib7 7206 1 Results result NNS cord-005453-4057qib7 7206 2 : : : cord-005453-4057qib7 7207 1 Three three CD cord-005453-4057qib7 7207 2 of of IN cord-005453-4057qib7 7207 3 the the DT cord-005453-4057qib7 7207 4 four four CD cord-005453-4057qib7 7207 5 children child NNS cord-005453-4057qib7 7207 6 survived survive VBD cord-005453-4057qib7 7207 7 transplant transplant NN cord-005453-4057qib7 7207 8 . . . cord-005453-4057qib7 7208 1 They -PRON- PRP cord-005453-4057qib7 7208 2 have have VBP cord-005453-4057qib7 7208 3 continued continue VBN cord-005453-4057qib7 7208 4 to to TO cord-005453-4057qib7 7208 5 receive receive VB cord-005453-4057qib7 7208 6 enzyme enzyme NN cord-005453-4057qib7 7208 7 replacement replacement NN cord-005453-4057qib7 7208 8 therapy therapy NN cord-005453-4057qib7 7208 9 but but CC cord-005453-4057qib7 7208 10 at at IN cord-005453-4057qib7 7208 11 reduced reduce VBN cord-005453-4057qib7 7208 12 dose dose NN cord-005453-4057qib7 7208 13 and and CC cord-005453-4057qib7 7208 14 frequency frequency NN cord-005453-4057qib7 7208 15 with with IN cord-005453-4057qib7 7208 16 improved improved JJ cord-005453-4057qib7 7208 17 tolerability tolerability NN cord-005453-4057qib7 7208 18 . . . cord-005453-4057qib7 7209 1 They -PRON- PRP cord-005453-4057qib7 7209 2 have have VBP cord-005453-4057qib7 7209 3 continues continue VBZ cord-005453-4057qib7 7209 4 to to TO cord-005453-4057qib7 7209 5 grow grow VB cord-005453-4057qib7 7209 6 and and CC cord-005453-4057qib7 7209 7 develop develop VB cord-005453-4057qib7 7209 8 . . . cord-005453-4057qib7 7210 1 Growth growth NN cord-005453-4057qib7 7210 2 and and CC cord-005453-4057qib7 7210 3 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 7210 4 histology histology NN cord-005453-4057qib7 7210 5 is be VBZ cord-005453-4057qib7 7210 6 improved improve VBN cord-005453-4057qib7 7210 7 for for IN cord-005453-4057qib7 7210 8 children child NNS cord-005453-4057qib7 7210 9 having have VBG cord-005453-4057qib7 7210 10 received receive VBN cord-005453-4057qib7 7210 11 transplant transplant NN cord-005453-4057qib7 7210 12 compared compare VBN cord-005453-4057qib7 7210 13 to to IN cord-005453-4057qib7 7210 14 those those DT cord-005453-4057qib7 7210 15 receiving receive VBG cord-005453-4057qib7 7210 16 enzyme enzyme NN cord-005453-4057qib7 7210 17 replacement replacement NN cord-005453-4057qib7 7210 18 alone alone RB cord-005453-4057qib7 7210 19 . . . cord-005453-4057qib7 7211 1 Monitoring monitoring NN cord-005453-4057qib7 7211 2 of of IN cord-005453-4057qib7 7211 3 peripheral peripheral JJ cord-005453-4057qib7 7211 4 blood blood NN cord-005453-4057qib7 7211 5 chimerism chimerism NN cord-005453-4057qib7 7211 6 has have VBZ cord-005453-4057qib7 7211 7 shown show VBN cord-005453-4057qib7 7211 8 a a DT cord-005453-4057qib7 7211 9 disease disease NN cord-005453-4057qib7 7211 10 - - HYPH cord-005453-4057qib7 7211 11 associated associate VBN cord-005453-4057qib7 7211 12 engraftment engraftment NN cord-005453-4057qib7 7211 13 defect defect NN cord-005453-4057qib7 7211 14 , , , cord-005453-4057qib7 7211 15 with with IN cord-005453-4057qib7 7211 16 mixed mixed JJ cord-005453-4057qib7 7211 17 chimerism chimerism NN cord-005453-4057qib7 7211 18 in in IN cord-005453-4057qib7 7211 19 the the DT cord-005453-4057qib7 7211 20 3 3 CD cord-005453-4057qib7 7211 21 surviving survive VBG cord-005453-4057qib7 7211 22 patient patient NN cord-005453-4057qib7 7211 23 . . . cord-005453-4057qib7 7212 1 Conclusions conclusion NNS cord-005453-4057qib7 7212 2 : : : cord-005453-4057qib7 7213 1 Haemopoietic haemopoietic JJ cord-005453-4057qib7 7213 2 stem stem NN cord-005453-4057qib7 7213 3 cell cell NN cord-005453-4057qib7 7213 4 transplant transplant NN cord-005453-4057qib7 7213 5 is be VBZ cord-005453-4057qib7 7213 6 a a DT cord-005453-4057qib7 7213 7 suitable suitable JJ cord-005453-4057qib7 7213 8 treatment treatment NN cord-005453-4057qib7 7213 9 option option NN cord-005453-4057qib7 7213 10 in in IN cord-005453-4057qib7 7213 11 children child NNS cord-005453-4057qib7 7213 12 with with IN cord-005453-4057qib7 7213 13 Wolman Wolman NNP cord-005453-4057qib7 7213 14 disease disease NN cord-005453-4057qib7 7213 15 in in IN cord-005453-4057qib7 7213 16 whom whom WP cord-005453-4057qib7 7213 17 receiving receive VBG cord-005453-4057qib7 7213 18 enzyme enzyme NN cord-005453-4057qib7 7213 19 replacement replacement NN cord-005453-4057qib7 7213 20 therapy therapy NN cord-005453-4057qib7 7213 21 is be VBZ cord-005453-4057qib7 7213 22 not not RB cord-005453-4057qib7 7213 23 possible possible JJ cord-005453-4057qib7 7213 24 because because IN cord-005453-4057qib7 7213 25 of of IN cord-005453-4057qib7 7213 26 venous venous JJ cord-005453-4057qib7 7213 27 access access NN cord-005453-4057qib7 7213 28 , , , cord-005453-4057qib7 7213 29 sensitisation sensitisation NN cord-005453-4057qib7 7213 30 or or CC cord-005453-4057qib7 7213 31 cost cost NN cord-005453-4057qib7 7213 32 reasons reason NNS cord-005453-4057qib7 7213 33 . . . cord-005453-4057qib7 7214 1 It -PRON- PRP cord-005453-4057qib7 7214 2 improves improve VBZ cord-005453-4057qib7 7214 3 their -PRON- PRP$ cord-005453-4057qib7 7214 4 tolerability tolerability NN cord-005453-4057qib7 7214 5 of of IN cord-005453-4057qib7 7214 6 the the DT cord-005453-4057qib7 7214 7 enzyme enzyme NN cord-005453-4057qib7 7214 8 treatment treatment NN cord-005453-4057qib7 7214 9 and and CC cord-005453-4057qib7 7214 10 allows allow VBZ cord-005453-4057qib7 7214 11 for for IN cord-005453-4057qib7 7214 12 a a DT cord-005453-4057qib7 7214 13 reduction reduction NN cord-005453-4057qib7 7214 14 in in IN cord-005453-4057qib7 7214 15 enzyme enzyme NN cord-005453-4057qib7 7214 16 dose dose NN cord-005453-4057qib7 7214 17 and and CC cord-005453-4057qib7 7214 18 frequency frequency NN cord-005453-4057qib7 7214 19 . . . cord-005453-4057qib7 7215 1 However however RB cord-005453-4057qib7 7215 2 , , , cord-005453-4057qib7 7215 3 the the DT cord-005453-4057qib7 7215 4 results result NNS cord-005453-4057qib7 7215 5 of of IN cord-005453-4057qib7 7215 6 engraftment engraftment NN cord-005453-4057qib7 7215 7 are be VBP cord-005453-4057qib7 7215 8 not not RB cord-005453-4057qib7 7215 9 as as RB cord-005453-4057qib7 7215 10 good good JJ cord-005453-4057qib7 7215 11 as as IN cord-005453-4057qib7 7215 12 expected expect VBN cord-005453-4057qib7 7215 13 for for IN cord-005453-4057qib7 7215 14 a a DT cord-005453-4057qib7 7215 15 transplant transplant NN cord-005453-4057qib7 7215 16 with with IN cord-005453-4057qib7 7215 17 myeloablative myeloablative JJ cord-005453-4057qib7 7215 18 conditioning conditioning NN cord-005453-4057qib7 7215 19 and and CC cord-005453-4057qib7 7215 20 a a DT cord-005453-4057qib7 7215 21 matched match VBN cord-005453-4057qib7 7215 22 donor donor NN cord-005453-4057qib7 7215 23 . . . cord-005453-4057qib7 7216 1 An an DT cord-005453-4057qib7 7216 2 engraftment engraftment NN cord-005453-4057qib7 7216 3 defect defect NN cord-005453-4057qib7 7216 4 has have VBZ cord-005453-4057qib7 7216 5 been be VBN cord-005453-4057qib7 7216 6 observed observe VBN cord-005453-4057qib7 7216 7 in in IN cord-005453-4057qib7 7216 8 lysosomal lysosomal JJ cord-005453-4057qib7 7216 9 acid acid NN cord-005453-4057qib7 7216 10 lipase lipase NN cord-005453-4057qib7 7216 11 deficient deficient JJ cord-005453-4057qib7 7216 12 animal animal NN cord-005453-4057qib7 7216 13 models model NNS cord-005453-4057qib7 7216 14 . . . cord-005453-4057qib7 7217 1 A a DT cord-005453-4057qib7 7217 2 further further JJ cord-005453-4057qib7 7217 3 understanding understanding NN cord-005453-4057qib7 7217 4 of of IN cord-005453-4057qib7 7217 5 this this DT cord-005453-4057qib7 7217 6 poor poor JJ cord-005453-4057qib7 7217 7 engraftment engraftment NN cord-005453-4057qib7 7217 8 in in IN cord-005453-4057qib7 7217 9 children child NNS cord-005453-4057qib7 7217 10 with with IN cord-005453-4057qib7 7217 11 Wolman Wolman NNP cord-005453-4057qib7 7217 12 disease disease NN cord-005453-4057qib7 7217 13 is be VBZ cord-005453-4057qib7 7217 14 required require VBN cord-005453-4057qib7 7217 15 as as IN cord-005453-4057qib7 7217 16 to to TO cord-005453-4057qib7 7217 17 determine determine VB cord-005453-4057qib7 7217 18 whether whether IN cord-005453-4057qib7 7217 19 the the DT cord-005453-4057qib7 7217 20 risks risk NNS cord-005453-4057qib7 7217 21 of of IN cord-005453-4057qib7 7217 22 transplant transplant NN cord-005453-4057qib7 7217 23 is be VBZ cord-005453-4057qib7 7217 24 beneficial beneficial JJ cord-005453-4057qib7 7217 25 in in IN cord-005453-4057qib7 7217 26 these these DT cord-005453-4057qib7 7217 27 patients patient NNS cord-005453-4057qib7 7217 28 and and CC cord-005453-4057qib7 7217 29 for for IN cord-005453-4057qib7 7217 30 the the DT cord-005453-4057qib7 7217 31 consideration consideration NN cord-005453-4057qib7 7217 32 of of IN cord-005453-4057qib7 7217 33 future future JJ cord-005453-4057qib7 7217 34 treatment treatment NN cord-005453-4057qib7 7217 35 options option NNS cord-005453-4057qib7 7217 36 including include VBG cord-005453-4057qib7 7217 37 gene gene NN cord-005453-4057qib7 7217 38 therapy therapy NN cord-005453-4057qib7 7217 39 . . . cord-005453-4057qib7 7218 1 Background background NN cord-005453-4057qib7 7218 2 : : : cord-005453-4057qib7 7219 1 Thalassemia thalassemia NN cord-005453-4057qib7 7219 2 major major NN cord-005453-4057qib7 7219 3 is be VBZ cord-005453-4057qib7 7219 4 the the DT cord-005453-4057qib7 7219 5 most most RBS cord-005453-4057qib7 7219 6 common common JJ cord-005453-4057qib7 7219 7 transfusion transfusion NN cord-005453-4057qib7 7219 8 dependent dependent JJ cord-005453-4057qib7 7219 9 hemolytic hemolytic JJ cord-005453-4057qib7 7219 10 anemia anemia NN cord-005453-4057qib7 7219 11 in in IN cord-005453-4057qib7 7219 12 the the DT cord-005453-4057qib7 7219 13 world world NN cord-005453-4057qib7 7219 14 . . . cord-005453-4057qib7 7220 1 The the DT cord-005453-4057qib7 7220 2 absent absent JJ cord-005453-4057qib7 7220 3 or or CC cord-005453-4057qib7 7220 4 reduced reduced JJ cord-005453-4057qib7 7220 5 production production NN cord-005453-4057qib7 7220 6 of of IN cord-005453-4057qib7 7220 7 the the DT cord-005453-4057qib7 7220 8 β β NN cord-005453-4057qib7 7220 9 - - HYPH cord-005453-4057qib7 7220 10 chain chain NN cord-005453-4057qib7 7220 11 of of IN cord-005453-4057qib7 7220 12 hemoglobin hemoglobin NN cord-005453-4057qib7 7220 13 causes cause VBZ cord-005453-4057qib7 7220 14 severe severe JJ cord-005453-4057qib7 7220 15 ineffective ineffective JJ cord-005453-4057qib7 7220 16 erythropoiesis erythropoiesis NN cord-005453-4057qib7 7220 17 , , , cord-005453-4057qib7 7220 18 massive massive JJ cord-005453-4057qib7 7220 19 erythroid erythroid JJ cord-005453-4057qib7 7220 20 hyperplasia hyperplasia NN cord-005453-4057qib7 7220 21 in in IN cord-005453-4057qib7 7220 22 the the DT cord-005453-4057qib7 7220 23 bone bone NN cord-005453-4057qib7 7220 24 marrow marrow NN cord-005453-4057qib7 7220 25 and and CC cord-005453-4057qib7 7220 26 extramedullary extramedullary NNP cord-005453-4057qib7 7220 27 hematopoesis hematopoesis NNP cord-005453-4057qib7 7220 28 occurs occur VBZ cord-005453-4057qib7 7220 29 . . . cord-005453-4057qib7 7221 1 Patients patient NNS cord-005453-4057qib7 7221 2 require require VBP cord-005453-4057qib7 7221 3 regular regular JJ cord-005453-4057qib7 7221 4 transfusion transfusion NN cord-005453-4057qib7 7221 5 therapy therapy NN cord-005453-4057qib7 7221 6 lifelong lifelong NN cord-005453-4057qib7 7221 7 . . . cord-005453-4057qib7 7222 1 Currently currently RB cord-005453-4057qib7 7222 2 , , , cord-005453-4057qib7 7222 3 the the DT cord-005453-4057qib7 7222 4 only only JJ cord-005453-4057qib7 7222 5 proven prove VBN cord-005453-4057qib7 7222 6 curative curative JJ cord-005453-4057qib7 7222 7 treatment treatment NN cord-005453-4057qib7 7222 8 of of IN cord-005453-4057qib7 7222 9 thalassemia thalassemia NN cord-005453-4057qib7 7222 10 is be VBZ cord-005453-4057qib7 7222 11 allogeneic allogeneic IN cord-005453-4057qib7 7222 12 stem stem NN cord-005453-4057qib7 7222 13 cell cell NN cord-005453-4057qib7 7222 14 transplantation transplantation NN cord-005453-4057qib7 7222 15 ( ( -LRB- cord-005453-4057qib7 7222 16 SCT SCT NNP cord-005453-4057qib7 7222 17 ) ) -RRB- cord-005453-4057qib7 7222 18 . . . cord-005453-4057qib7 7223 1 Methods method NNS cord-005453-4057qib7 7223 2 : : : cord-005453-4057qib7 7223 3 We -PRON- PRP cord-005453-4057qib7 7223 4 evaluated evaluate VBD cord-005453-4057qib7 7223 5 the the DT cord-005453-4057qib7 7223 6 immune immune JJ cord-005453-4057qib7 7223 7 reconstitution reconstitution NN cord-005453-4057qib7 7223 8 results result NNS cord-005453-4057qib7 7223 9 of of IN cord-005453-4057qib7 7223 10 23 23 CD cord-005453-4057qib7 7223 11 patients patient NNS cord-005453-4057qib7 7223 12 at at IN cord-005453-4057qib7 7223 13 1 1 CD cord-005453-4057qib7 7223 14 year year NN cord-005453-4057qib7 7223 15 after after IN cord-005453-4057qib7 7223 16 hematopoetic hematopoetic JJ cord-005453-4057qib7 7223 17 stem stem NN cord-005453-4057qib7 7223 18 cell cell NN cord-005453-4057qib7 7223 19 transplantation transplantation NN cord-005453-4057qib7 7223 20 at at IN cord-005453-4057qib7 7223 21 our -PRON- PRP$ cord-005453-4057qib7 7223 22 pediatric pediatric JJ cord-005453-4057qib7 7223 23 bone bone NN cord-005453-4057qib7 7223 24 marrow marrow NN cord-005453-4057qib7 7223 25 transplantation transplantation NN cord-005453-4057qib7 7223 26 center center NN cord-005453-4057qib7 7223 27 between between IN cord-005453-4057qib7 7223 28 January January NNP cord-005453-4057qib7 7223 29 2015 2015 CD cord-005453-4057qib7 7223 30 and and CC cord-005453-4057qib7 7223 31 December December NNP cord-005453-4057qib7 7223 32 2018 2018 CD cord-005453-4057qib7 7223 33 . . . cord-005453-4057qib7 7224 1 All all DT cord-005453-4057qib7 7224 2 patients patient NNS cord-005453-4057qib7 7224 3 were be VBD cord-005453-4057qib7 7224 4 not not RB cord-005453-4057qib7 7224 5 receiving receive VBG cord-005453-4057qib7 7224 6 any any DT cord-005453-4057qib7 7224 7 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 7224 8 treatment treatment NN cord-005453-4057qib7 7224 9 at at IN cord-005453-4057qib7 7224 10 least least JJS cord-005453-4057qib7 7224 11 for for IN cord-005453-4057qib7 7224 12 3 3 CD cord-005453-4057qib7 7224 13 months month NNS cord-005453-4057qib7 7224 14 and and CC cord-005453-4057qib7 7224 15 they -PRON- PRP cord-005453-4057qib7 7224 16 have have VBP cord-005453-4057qib7 7224 17 normal normal JJ cord-005453-4057qib7 7224 18 lymphocyte lymphocyte NN cord-005453-4057qib7 7224 19 counts count NNS cord-005453-4057qib7 7224 20 , , , cord-005453-4057qib7 7224 21 immunoglobulin immunoglobulin NN cord-005453-4057qib7 7224 22 levels level NNS cord-005453-4057qib7 7224 23 and and CC cord-005453-4057qib7 7224 24 transfusion transfusion NN cord-005453-4057qib7 7224 25 independent independent JJ cord-005453-4057qib7 7224 26 . . . cord-005453-4057qib7 7225 1 Lymphocyte lymphocyte NN cord-005453-4057qib7 7225 2 subtypes subtype NNS cord-005453-4057qib7 7225 3 and and CC cord-005453-4057qib7 7225 4 chimerism chimerism NN cord-005453-4057qib7 7225 5 percentages percentage NNS cord-005453-4057qib7 7225 6 and and CC cord-005453-4057qib7 7225 7 the the DT cord-005453-4057qib7 7225 8 relationship relationship NN cord-005453-4057qib7 7225 9 with with IN cord-005453-4057qib7 7225 10 the the DT cord-005453-4057qib7 7225 11 donor donor NN cord-005453-4057qib7 7225 12 type type NN cord-005453-4057qib7 7225 13 were be VBD cord-005453-4057qib7 7225 14 evaluated evaluate VBN cord-005453-4057qib7 7225 15 at at IN cord-005453-4057qib7 7225 16 1 1 CD cord-005453-4057qib7 7225 17 year year NN cord-005453-4057qib7 7225 18 of of IN cord-005453-4057qib7 7225 19 transplantation transplantation NN cord-005453-4057qib7 7225 20 . . . cord-005453-4057qib7 7226 1 Results result NNS cord-005453-4057qib7 7226 2 : : : cord-005453-4057qib7 7227 1 Ages age NNS cord-005453-4057qib7 7227 2 of of IN cord-005453-4057qib7 7227 3 transplantation transplantation NN cord-005453-4057qib7 7227 4 was be VBD cord-005453-4057qib7 7227 5 ranged range VBN cord-005453-4057qib7 7227 6 between between IN cord-005453-4057qib7 7227 7 1 1 CD cord-005453-4057qib7 7227 8 - - SYM cord-005453-4057qib7 7227 9 17 17 CD cord-005453-4057qib7 7227 10 years year NNS cord-005453-4057qib7 7227 11 ( ( -LRB- cord-005453-4057qib7 7227 12 Median median NN cord-005453-4057qib7 7227 13 : : : cord-005453-4057qib7 7227 14 5 5 CD cord-005453-4057qib7 7227 15 years year NNS cord-005453-4057qib7 7227 16 ) ) -RRB- cord-005453-4057qib7 7227 17 . . . cord-005453-4057qib7 7228 1 Seven seven CD cord-005453-4057qib7 7228 2 ( ( -LRB- cord-005453-4057qib7 7228 3 30 30 CD cord-005453-4057qib7 7228 4 % % NN cord-005453-4057qib7 7228 5 ) ) -RRB- cord-005453-4057qib7 7228 6 of of IN cord-005453-4057qib7 7228 7 them -PRON- PRP cord-005453-4057qib7 7228 8 was be VBD cord-005453-4057qib7 7228 9 male male JJ cord-005453-4057qib7 7228 10 . . . cord-005453-4057qib7 7229 1 Matched matched JJ cord-005453-4057qib7 7229 2 unrelated unrelated JJ cord-005453-4057qib7 7229 3 donor donor NN cord-005453-4057qib7 7229 4 type type NN cord-005453-4057qib7 7229 5 was be VBD cord-005453-4057qib7 7229 6 chosen choose VBN cord-005453-4057qib7 7229 7 in in IN cord-005453-4057qib7 7229 8 7 7 CD cord-005453-4057qib7 7229 9 patients patient NNS cord-005453-4057qib7 7229 10 while while IN cord-005453-4057qib7 7229 11 others other NNS cord-005453-4057qib7 7229 12 ( ( -LRB- cord-005453-4057qib7 7229 13 16 16 CD cord-005453-4057qib7 7229 14 patients patient NNS cord-005453-4057qib7 7229 15 ) ) -RRB- cord-005453-4057qib7 7229 16 were be VBD cord-005453-4057qib7 7229 17 transplanted transplant VBN cord-005453-4057qib7 7229 18 from from IN cord-005453-4057qib7 7229 19 family family NN cord-005453-4057qib7 7229 20 matched match VBN cord-005453-4057qib7 7229 21 donor donor NN cord-005453-4057qib7 7229 22 ( ( -LRB- cord-005453-4057qib7 7229 23 Matched match VBN cord-005453-4057qib7 7229 24 sibling sibling NN cord-005453-4057qib7 7229 25 : : : cord-005453-4057qib7 7229 26 9 9 CD cord-005453-4057qib7 7229 27 patients patient NNS cord-005453-4057qib7 7229 28 , , , cord-005453-4057qib7 7229 29 Matched match VBN cord-005453-4057qib7 7229 30 family family NN cord-005453-4057qib7 7229 31 : : : cord-005453-4057qib7 7229 32 7 7 CD cord-005453-4057qib7 7229 33 patients patient NNS cord-005453-4057qib7 7229 34 ) ) -RRB- cord-005453-4057qib7 7229 35 . . . cord-005453-4057qib7 7230 1 All all DT cord-005453-4057qib7 7230 2 patients patient NNS cord-005453-4057qib7 7230 3 received receive VBD cord-005453-4057qib7 7230 4 myeloablative myeloablative NNP cord-005453-4057qib7 7230 5 conditioning conditioning NN cord-005453-4057qib7 7230 6 regimen regimen NN cord-005453-4057qib7 7230 7 containing contain VBG cord-005453-4057qib7 7230 8 busulfan busulfan NN cord-005453-4057qib7 7230 9 / / SYM cord-005453-4057qib7 7230 10 treosulfan treosulfan NNP cord-005453-4057qib7 7230 11 , , , cord-005453-4057qib7 7230 12 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 7230 13 , , , cord-005453-4057qib7 7230 14 thiotepa thiotepa NN cord-005453-4057qib7 7230 15 and and CC cord-005453-4057qib7 7230 16 fludarabine fludarabine NN cord-005453-4057qib7 7230 17 . . . cord-005453-4057qib7 7231 1 Follow follow VB cord-005453-4057qib7 7231 2 up up RP cord-005453-4057qib7 7231 3 time time NN cord-005453-4057qib7 7231 4 was be VBD cord-005453-4057qib7 7231 5 between between IN cord-005453-4057qib7 7231 6 12 12 CD cord-005453-4057qib7 7231 7 - - SYM cord-005453-4057qib7 7231 8 47 47 CD cord-005453-4057qib7 7231 9 months month NNS cord-005453-4057qib7 7232 1 ( ( -LRB- cord-005453-4057qib7 7232 2 Mean mean JJ cord-005453-4057qib7 7232 3 : : : cord-005453-4057qib7 7232 4 24 24 CD cord-005453-4057qib7 7232 5 ± ± CD cord-005453-4057qib7 7232 6 10 10 CD cord-005453-4057qib7 7232 7 months month NNS cord-005453-4057qib7 7232 8 ) ) -RRB- cord-005453-4057qib7 7232 9 . . . cord-005453-4057qib7 7233 1 In in IN cord-005453-4057qib7 7233 2 9 9 CD cord-005453-4057qib7 7233 3 patients patient NNS cord-005453-4057qib7 7233 4 , , , cord-005453-4057qib7 7233 5 whole whole JJ cord-005453-4057qib7 7233 6 bone bone NN cord-005453-4057qib7 7233 7 marrow marrow NN cord-005453-4057qib7 7233 8 product product NN cord-005453-4057qib7 7233 9 was be VBD cord-005453-4057qib7 7233 10 used use VBN cord-005453-4057qib7 7233 11 while while IN cord-005453-4057qib7 7233 12 peripheral peripheral JJ cord-005453-4057qib7 7233 13 stem stem NN cord-005453-4057qib7 7233 14 cell cell NN cord-005453-4057qib7 7233 15 harvest harvest NN cord-005453-4057qib7 7233 16 in in IN cord-005453-4057qib7 7233 17 remaining remain VBG cord-005453-4057qib7 7233 18 patients patient NNS cord-005453-4057qib7 7233 19 . . . cord-005453-4057qib7 7234 1 CD3 CD3 NNP cord-005453-4057qib7 7234 2 levels level NNS cord-005453-4057qib7 7234 3 were be VBD cord-005453-4057qib7 7234 4 found find VBN cord-005453-4057qib7 7234 5 low low JJ cord-005453-4057qib7 7234 6 in in IN cord-005453-4057qib7 7234 7 only only RB cord-005453-4057qib7 7234 8 4 4 CD cord-005453-4057qib7 7234 9 patients patient NNS cord-005453-4057qib7 7234 10 , , , cord-005453-4057qib7 7234 11 in in IN cord-005453-4057qib7 7234 12 normal normal JJ cord-005453-4057qib7 7234 13 patients patient NNS cord-005453-4057qib7 7234 14 mean mean JJ cord-005453-4057qib7 7234 15 was be VBD cord-005453-4057qib7 7234 16 59 59 CD cord-005453-4057qib7 7234 17 % % NN cord-005453-4057qib7 7234 18 ± ± CD cord-005453-4057qib7 7234 19 14 14 CD cord-005453-4057qib7 7234 20 % % NN cord-005453-4057qib7 7234 21 . . . cord-005453-4057qib7 7235 1 CD4 CD4 NNP cord-005453-4057qib7 7235 2 levels level NNS cord-005453-4057qib7 7235 3 were be VBD cord-005453-4057qib7 7235 4 severely severely RB cord-005453-4057qib7 7235 5 low low JJ cord-005453-4057qib7 7235 6 in in IN cord-005453-4057qib7 7235 7 18 18 CD cord-005453-4057qib7 7235 8 patients patient NNS cord-005453-4057qib7 7235 9 while while IN cord-005453-4057qib7 7235 10 CD8 CD8 NNP cord-005453-4057qib7 7235 11 in in IN cord-005453-4057qib7 7235 12 only only RB cord-005453-4057qib7 7235 13 1 1 CD cord-005453-4057qib7 7235 14 patient patient NN cord-005453-4057qib7 7235 15 . . . cord-005453-4057qib7 7236 1 CD8 CD8 NNP cord-005453-4057qib7 7236 2 levels level NNS cord-005453-4057qib7 7236 3 were be VBD cord-005453-4057qib7 7236 4 increased increase VBN cord-005453-4057qib7 7236 5 in in IN cord-005453-4057qib7 7236 6 total total JJ cord-005453-4057qib7 7236 7 13 13 CD cord-005453-4057qib7 7236 8 patients patient NNS cord-005453-4057qib7 7236 9 in in IN cord-005453-4057qib7 7236 10 as as RB cord-005453-4057qib7 7236 11 compensatory compensatory JJ cord-005453-4057qib7 7236 12 . . . cord-005453-4057qib7 7237 1 CD4 CD4 NNP cord-005453-4057qib7 7237 2 / / SYM cord-005453-4057qib7 7237 3 CD8 CD8 NNP cord-005453-4057qib7 7237 4 ratios ratio NNS cord-005453-4057qib7 7237 5 were be VBD cord-005453-4057qib7 7237 6 very very RB cord-005453-4057qib7 7237 7 low low JJ cord-005453-4057qib7 7237 8 in in IN cord-005453-4057qib7 7237 9 all all DT cord-005453-4057qib7 7237 10 patients patient NNS cord-005453-4057qib7 7237 11 ( ( -LRB- cord-005453-4057qib7 7237 12 Range range NN cord-005453-4057qib7 7237 13 : : : cord-005453-4057qib7 7237 14 0.2 0.2 CD cord-005453-4057qib7 7237 15 - - SYM cord-005453-4057qib7 7237 16 0.7 0.7 CD cord-005453-4057qib7 7237 17 ) ) -RRB- cord-005453-4057qib7 7237 18 . . . cord-005453-4057qib7 7238 1 B b NN cord-005453-4057qib7 7238 2 cells cell NNS cord-005453-4057qib7 7238 3 ( ( -LRB- cord-005453-4057qib7 7238 4 CD19 CD19 NNP cord-005453-4057qib7 7238 5 + + CC cord-005453-4057qib7 7238 6 ) ) -RRB- cord-005453-4057qib7 7238 7 were be VBD cord-005453-4057qib7 7238 8 low low JJ cord-005453-4057qib7 7238 9 in in IN cord-005453-4057qib7 7238 10 3 3 CD cord-005453-4057qib7 7238 11 patients patient NNS cord-005453-4057qib7 7238 12 while while IN cord-005453-4057qib7 7238 13 immunoglobulin immunoglobulin NN cord-005453-4057qib7 7238 14 levels level NNS cord-005453-4057qib7 7238 15 were be VBD cord-005453-4057qib7 7238 16 normal normal JJ cord-005453-4057qib7 7238 17 . . . cord-005453-4057qib7 7239 1 Chimerism chimerism NN cord-005453-4057qib7 7239 2 values value NNS cord-005453-4057qib7 7239 3 between between IN cord-005453-4057qib7 7239 4 55 55 CD cord-005453-4057qib7 7239 5 - - SYM cord-005453-4057qib7 7239 6 99 99 CD cord-005453-4057qib7 7239 7 % % NN cord-005453-4057qib7 7240 1 ( ( -LRB- cord-005453-4057qib7 7240 2 Mean mean JJ cord-005453-4057qib7 7240 3 : : : cord-005453-4057qib7 7240 4 93 93 CD cord-005453-4057qib7 7240 5 ± ± CD cord-005453-4057qib7 7240 6 11 11 CD cord-005453-4057qib7 7240 7 % % NN cord-005453-4057qib7 7240 8 ) ) -RRB- cord-005453-4057qib7 7240 9 . . . cord-005453-4057qib7 7241 1 Donor donor NN cord-005453-4057qib7 7241 2 and and CC cord-005453-4057qib7 7241 3 product product NN cord-005453-4057qib7 7241 4 types type NNS cord-005453-4057qib7 7241 5 did do VBD cord-005453-4057qib7 7241 6 not not RB cord-005453-4057qib7 7241 7 differ differ VB cord-005453-4057qib7 7241 8 in in IN cord-005453-4057qib7 7241 9 CD3 CD3 NNP cord-005453-4057qib7 7241 10 + + CC cord-005453-4057qib7 7241 11 lymphocyte lymphocyte NN cord-005453-4057qib7 7241 12 reconstitution reconstitution NN cord-005453-4057qib7 7241 13 at at IN cord-005453-4057qib7 7241 14 1 1 CD cord-005453-4057qib7 7241 15 year year NN cord-005453-4057qib7 7242 1 ( ( -LRB- cord-005453-4057qib7 7242 2 p=0.15 p=0.15 NNP cord-005453-4057qib7 7242 3 , , , cord-005453-4057qib7 7242 4 P=042 p=042 NN cord-005453-4057qib7 7242 5 respectively respectively RB cord-005453-4057qib7 7242 6 ) ) -RRB- cord-005453-4057qib7 7242 7 . . . cord-005453-4057qib7 7243 1 All all DT cord-005453-4057qib7 7243 2 patients patient NNS cord-005453-4057qib7 7243 3 were be VBD cord-005453-4057qib7 7243 4 alive alive JJ cord-005453-4057qib7 7243 5 and and CC cord-005453-4057qib7 7243 6 well well RB cord-005453-4057qib7 7243 7 at at IN cord-005453-4057qib7 7243 8 1 1 CD cord-005453-4057qib7 7243 9 year year NN cord-005453-4057qib7 7243 10 after after IN cord-005453-4057qib7 7243 11 transplantation transplantation NN cord-005453-4057qib7 7243 12 . . . cord-005453-4057qib7 7244 1 Conclusions conclusion NNS cord-005453-4057qib7 7244 2 : : : cord-005453-4057qib7 7245 1 After after IN cord-005453-4057qib7 7245 2 1 1 CD cord-005453-4057qib7 7245 3 year year NN cord-005453-4057qib7 7245 4 of of IN cord-005453-4057qib7 7245 5 transplantation transplantation NN cord-005453-4057qib7 7245 6 , , , cord-005453-4057qib7 7245 7 although although IN cord-005453-4057qib7 7245 8 patients patient NNS cord-005453-4057qib7 7245 9 are be VBP cord-005453-4057qib7 7245 10 in in IN cord-005453-4057qib7 7245 11 well well JJ cord-005453-4057qib7 7245 12 condition condition NN cord-005453-4057qib7 7245 13 regarding regard VBG cord-005453-4057qib7 7245 14 to to IN cord-005453-4057qib7 7245 15 infection infection NN cord-005453-4057qib7 7245 16 frequency frequency NN cord-005453-4057qib7 7245 17 and and CC cord-005453-4057qib7 7245 18 transfussion transfussion NN cord-005453-4057qib7 7245 19 dependency dependency NN cord-005453-4057qib7 7245 20 , , , cord-005453-4057qib7 7245 21 it -PRON- PRP cord-005453-4057qib7 7245 22 was be VBD cord-005453-4057qib7 7245 23 seen see VBN cord-005453-4057qib7 7245 24 that that IN cord-005453-4057qib7 7245 25 their -PRON- PRP$ cord-005453-4057qib7 7245 26 lymphocyte lymphocyte NN cord-005453-4057qib7 7245 27 subtypes subtype NNS cord-005453-4057qib7 7245 28 reconstitution reconstitution NN cord-005453-4057qib7 7245 29 could could MD cord-005453-4057qib7 7245 30 not not RB cord-005453-4057qib7 7245 31 be be VB cord-005453-4057qib7 7245 32 achieved achieve VBN cord-005453-4057qib7 7245 33 enough enough RB cord-005453-4057qib7 7245 34 as as IN cord-005453-4057qib7 7245 35 in in IN cord-005453-4057qib7 7245 36 normal normal JJ cord-005453-4057qib7 7245 37 children child NNS cord-005453-4057qib7 7245 38 . . . cord-005453-4057qib7 7246 1 We -PRON- PRP cord-005453-4057qib7 7246 2 can can MD cord-005453-4057qib7 7246 3 conclude conclude VB cord-005453-4057qib7 7246 4 that that IN cord-005453-4057qib7 7246 5 low low JJ cord-005453-4057qib7 7246 6 CD4 CD4 NNP cord-005453-4057qib7 7246 7 + + CC cord-005453-4057qib7 7246 8 cell cell NN cord-005453-4057qib7 7246 9 levels level NNS cord-005453-4057qib7 7246 10 were be VBD cord-005453-4057qib7 7246 11 an an DT cord-005453-4057qib7 7246 12 expected expect VBN cord-005453-4057qib7 7246 13 finding finding NN cord-005453-4057qib7 7246 14 in in IN cord-005453-4057qib7 7246 15 almost almost RB cord-005453-4057qib7 7246 16 all all DT cord-005453-4057qib7 7246 17 patients patient NNS cord-005453-4057qib7 7246 18 . . . cord-005453-4057qib7 7247 1 So so RB cord-005453-4057qib7 7247 2 , , , cord-005453-4057qib7 7247 3 these these DT cord-005453-4057qib7 7247 4 patients patient NNS cord-005453-4057qib7 7247 5 may may MD cord-005453-4057qib7 7247 6 have have VB cord-005453-4057qib7 7247 7 a a DT cord-005453-4057qib7 7247 8 tendency tendency NN cord-005453-4057qib7 7247 9 to to TO cord-005453-4057qib7 7247 10 suffer suffer VB cord-005453-4057qib7 7247 11 serious serious JJ cord-005453-4057qib7 7247 12 bacterial bacterial JJ cord-005453-4057qib7 7247 13 and and CC cord-005453-4057qib7 7247 14 viral viral JJ cord-005453-4057qib7 7247 15 infections infection NNS cord-005453-4057qib7 7247 16 , , , cord-005453-4057qib7 7247 17 and and CC cord-005453-4057qib7 7247 18 close close VB cord-005453-4057qib7 7247 19 follow follow NN cord-005453-4057qib7 7247 20 up up RP cord-005453-4057qib7 7247 21 be be VB cord-005453-4057qib7 7247 22 required require VBN cord-005453-4057qib7 7247 23 in in IN cord-005453-4057qib7 7247 24 terms term NNS cord-005453-4057qib7 7247 25 of of IN cord-005453-4057qib7 7247 26 infections infection NNS cord-005453-4057qib7 7247 27 as as RB cord-005453-4057qib7 7247 28 long long RB cord-005453-4057qib7 7247 29 as as IN cord-005453-4057qib7 7247 30 CD4 CD4 NNP cord-005453-4057qib7 7247 31 levels level NNS cord-005453-4057qib7 7247 32 continue continue VBP cord-005453-4057qib7 7247 33 to to TO cord-005453-4057qib7 7247 34 be be VB cord-005453-4057qib7 7247 35 low low JJ cord-005453-4057qib7 7247 36 . . . cord-005453-4057qib7 7248 1 Immunoglobulin immunoglobulin NN cord-005453-4057qib7 7248 2 replacement replacement NN cord-005453-4057qib7 7248 3 therapy therapy NN cord-005453-4057qib7 7248 4 did do VBD cord-005453-4057qib7 7248 5 not not RB cord-005453-4057qib7 7248 6 required require VBN cord-005453-4057qib7 7248 7 even even RB cord-005453-4057qib7 7248 8 in in IN cord-005453-4057qib7 7248 9 patients patient NNS cord-005453-4057qib7 7248 10 with with IN cord-005453-4057qib7 7248 11 low low JJ cord-005453-4057qib7 7248 12 B b NN cord-005453-4057qib7 7248 13 cell cell NN cord-005453-4057qib7 7248 14 levels level NNS cord-005453-4057qib7 7248 15 . . . cord-005453-4057qib7 7249 1 Disclosure disclosure NN cord-005453-4057qib7 7249 2 : : : cord-005453-4057qib7 7249 3 Nothing nothing NN cord-005453-4057qib7 7249 4 to to TO cord-005453-4057qib7 7249 5 declare declare VB cord-005453-4057qib7 7249 6 P328 P328 NNP cord-005453-4057qib7 7249 7 Phase phase NN cord-005453-4057qib7 7249 8 2 2 CD cord-005453-4057qib7 7249 9 international international JJ cord-005453-4057qib7 7249 10 , , , cord-005453-4057qib7 7249 11 multicentre multicentre NNP cord-005453-4057qib7 7249 12 trial trial NN cord-005453-4057qib7 7249 13 to to TO cord-005453-4057qib7 7249 14 assess assess VB cord-005453-4057qib7 7249 15 haploidentical haploidentical JJ cord-005453-4057qib7 7249 16 Aß Aß NNP cord-005453-4057qib7 7249 17 T t NN cord-005453-4057qib7 7249 18 - - HYPH cord-005453-4057qib7 7249 19 cell cell NN cord-005453-4057qib7 7249 20 depleted deplete VBN cord-005453-4057qib7 7249 21 stem stem NN cord-005453-4057qib7 7249 22 cell cell NN cord-005453-4057qib7 7249 23 transplantation transplantation NN cord-005453-4057qib7 7249 24 in in IN cord-005453-4057qib7 7249 25 patients patient NNS cord-005453-4057qib7 7249 26 with with IN cord-005453-4057qib7 7249 27 sickle sickle NN cord-005453-4057qib7 7249 28 cell cell NN cord-005453-4057qib7 7249 29 disease disease NN cord-005453-4057qib7 7249 30 with with IN cord-005453-4057qib7 7249 31 no no DT cord-005453-4057qib7 7249 32 available available JJ cord-005453-4057qib7 7249 33 sibling sibling NN cord-005453-4057qib7 7249 34 donor donor NN cord-005453-4057qib7 7249 35 Background background NN cord-005453-4057qib7 7249 36 : : : cord-005453-4057qib7 7250 1 Sickle sickle NN cord-005453-4057qib7 7250 2 cell cell NN cord-005453-4057qib7 7250 3 disease disease NN cord-005453-4057qib7 7250 4 ( ( -LRB- cord-005453-4057qib7 7250 5 SCD SCD NNP cord-005453-4057qib7 7250 6 ) ) -RRB- cord-005453-4057qib7 7250 7 is be VBZ cord-005453-4057qib7 7250 8 an an DT cord-005453-4057qib7 7250 9 inherited inherit VBN cord-005453-4057qib7 7250 10 disorder disorder NN cord-005453-4057qib7 7250 11 with with IN cord-005453-4057qib7 7250 12 an an DT cord-005453-4057qib7 7250 13 estimate estimate NN cord-005453-4057qib7 7250 14 of of IN cord-005453-4057qib7 7250 15 300,000 300,000 CD cord-005453-4057qib7 7250 16 affected affect VBN cord-005453-4057qib7 7250 17 newborns newborn NNS cord-005453-4057qib7 7250 18 per per IN cord-005453-4057qib7 7250 19 year year NN cord-005453-4057qib7 7250 20 worldwide worldwide RB cord-005453-4057qib7 7250 21 . . . cord-005453-4057qib7 7251 1 Allogeneic allogeneic IN cord-005453-4057qib7 7251 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 7251 3 stem stem NN cord-005453-4057qib7 7251 4 cell cell NN cord-005453-4057qib7 7251 5 transplantation transplantation NN cord-005453-4057qib7 7251 6 ( ( -LRB- cord-005453-4057qib7 7251 7 HSCT HSCT NNP cord-005453-4057qib7 7251 8 ) ) -RRB- cord-005453-4057qib7 7251 9 with with IN cord-005453-4057qib7 7251 10 a a DT cord-005453-4057qib7 7251 11 matched match VBN cord-005453-4057qib7 7251 12 sibling sibling NN cord-005453-4057qib7 7251 13 donor donor NN cord-005453-4057qib7 7251 14 ( ( -LRB- cord-005453-4057qib7 7251 15 MSD MSD NNP cord-005453-4057qib7 7251 16 ) ) -RRB- cord-005453-4057qib7 7251 17 is be VBZ cord-005453-4057qib7 7251 18 currently currently RB cord-005453-4057qib7 7251 19 the the DT cord-005453-4057qib7 7251 20 curative curative JJ cord-005453-4057qib7 7251 21 standard standard NN cord-005453-4057qib7 7251 22 of of IN cord-005453-4057qib7 7251 23 care care NN cord-005453-4057qib7 7251 24 for for IN cord-005453-4057qib7 7251 25 SCD SCD NNP cord-005453-4057qib7 7251 26 patients patient NNS cord-005453-4057qib7 7251 27 ( ( -LRB- cord-005453-4057qib7 7251 28 pts pts NNP cord-005453-4057qib7 7251 29 ) ) -RRB- cord-005453-4057qib7 7251 30 . . . cord-005453-4057qib7 7252 1 However however RB cord-005453-4057qib7 7252 2 , , , cord-005453-4057qib7 7252 3 MSD MSD NNP cord-005453-4057qib7 7252 4 availability availability NN cord-005453-4057qib7 7252 5 is be VBZ cord-005453-4057qib7 7252 6 < < XX cord-005453-4057qib7 7252 7 20 20 CD cord-005453-4057qib7 7252 8 % % NN cord-005453-4057qib7 7252 9 . . . cord-005453-4057qib7 7253 1 A a DT cord-005453-4057qib7 7253 2 T t NN cord-005453-4057qib7 7253 3 - - HYPH cord-005453-4057qib7 7253 4 cell cell NN cord-005453-4057qib7 7253 5 depleted deplete VBN cord-005453-4057qib7 7253 6 haploidentical haploidentical JJ cord-005453-4057qib7 7253 7 HSCT HSCT NNP cord-005453-4057qib7 7254 1 ( ( -LRB- cord-005453-4057qib7 7254 2 T t NN cord-005453-4057qib7 7254 3 - - HYPH cord-005453-4057qib7 7254 4 haplo haplo NNP cord-005453-4057qib7 7254 5 - - HYPH cord-005453-4057qib7 7254 6 HSCT HSCT NNP cord-005453-4057qib7 7254 7 ) ) -RRB- cord-005453-4057qib7 7254 8 from from IN cord-005453-4057qib7 7254 9 a a DT cord-005453-4057qib7 7254 10 relative relative NN cord-005453-4057qib7 7254 11 , , , cord-005453-4057qib7 7254 12 mostly mostly RB cord-005453-4057qib7 7254 13 a a DT cord-005453-4057qib7 7254 14 parent parent NN cord-005453-4057qib7 7254 15 , , , cord-005453-4057qib7 7254 16 expands expand VBZ cord-005453-4057qib7 7254 17 the the DT cord-005453-4057qib7 7254 18 donor donor NN cord-005453-4057qib7 7254 19 availability availability NN cord-005453-4057qib7 7254 20 while while IN cord-005453-4057qib7 7254 21 exhibiting exhibit VBG cord-005453-4057qib7 7254 22 low low JJ cord-005453-4057qib7 7254 23 GvHD gvhd NN cord-005453-4057qib7 7254 24 rates rate NNS cord-005453-4057qib7 7254 25 and and CC cord-005453-4057qib7 7254 26 thus thus RB cord-005453-4057qib7 7254 27 could could MD cord-005453-4057qib7 7254 28 offer offer VB cord-005453-4057qib7 7254 29 cure cure NN cord-005453-4057qib7 7254 30 to to IN cord-005453-4057qib7 7254 31 the the DT cord-005453-4057qib7 7254 32 remaining remain VBG cord-005453-4057qib7 7254 33 80 80 CD cord-005453-4057qib7 7254 34 % % NN cord-005453-4057qib7 7254 35 of of IN cord-005453-4057qib7 7254 36 SCD SCD NNP cord-005453-4057qib7 7254 37 patients patient NNS cord-005453-4057qib7 7254 38 . . . cord-005453-4057qib7 7255 1 In in IN cord-005453-4057qib7 7255 2 a a DT cord-005453-4057qib7 7255 3 pilot pilot NN cord-005453-4057qib7 7255 4 study study NN cord-005453-4057qib7 7255 5 , , , cord-005453-4057qib7 7255 6 comparing compare VBG cord-005453-4057qib7 7255 7 T t NN cord-005453-4057qib7 7255 8 - - HYPH cord-005453-4057qib7 7255 9 haplo haplo NNP cord-005453-4057qib7 7255 10 - - HYPH cord-005453-4057qib7 7255 11 HSCT HSCT NNP cord-005453-4057qib7 7255 12 with with IN cord-005453-4057qib7 7255 13 MSD MSD NNP cord-005453-4057qib7 7255 14 HSCT HSCT NNP cord-005453-4057qib7 7255 15 in in IN cord-005453-4057qib7 7255 16 advanced advanced JJ cord-005453-4057qib7 7255 17 stage stage NN cord-005453-4057qib7 7255 18 SCD SCD NNP cord-005453-4057qib7 7255 19 , , , cord-005453-4057qib7 7255 20 using use VBG cord-005453-4057qib7 7255 21 almost almost RB cord-005453-4057qib7 7255 22 identical identical JJ cord-005453-4057qib7 7255 23 transplant transplant NN cord-005453-4057qib7 7255 24 regimens regimen NNS cord-005453-4057qib7 7255 25 for for IN cord-005453-4057qib7 7255 26 both both DT cord-005453-4057qib7 7255 27 . . . cord-005453-4057qib7 7256 1 The the DT cord-005453-4057qib7 7256 2 overall overall JJ cord-005453-4057qib7 7256 3 ( ( -LRB- cord-005453-4057qib7 7256 4 OS OS NNP cord-005453-4057qib7 7256 5 ) ) -RRB- cord-005453-4057qib7 7256 6 and and CC cord-005453-4057qib7 7256 7 disease disease NN cord-005453-4057qib7 7256 8 - - HYPH cord-005453-4057qib7 7256 9 free free JJ cord-005453-4057qib7 7256 10 survival survival NN cord-005453-4057qib7 7256 11 ( ( -LRB- cord-005453-4057qib7 7256 12 DFS DFS NNP cord-005453-4057qib7 7256 13 ) ) -RRB- cord-005453-4057qib7 7256 14 was be VBD cord-005453-4057qib7 7256 15 90 90 CD cord-005453-4057qib7 7256 16 % % NN cord-005453-4057qib7 7256 17 vs. vs. CC cord-005453-4057qib7 7256 18 100 100 CD cord-005453-4057qib7 7256 19 % % NN cord-005453-4057qib7 7256 20 , , , cord-005453-4057qib7 7256 21 respectively respectively RB cord-005453-4057qib7 7256 22 . . . cord-005453-4057qib7 7257 1 Methods method NNS cord-005453-4057qib7 7257 2 : : : cord-005453-4057qib7 7258 1 These these DT cord-005453-4057qib7 7258 2 results result NNS cord-005453-4057qib7 7258 3 led lead VBD cord-005453-4057qib7 7258 4 to to IN cord-005453-4057qib7 7258 5 the the DT cord-005453-4057qib7 7258 6 design design NN cord-005453-4057qib7 7258 7 of of IN cord-005453-4057qib7 7258 8 a a DT cord-005453-4057qib7 7258 9 clinical clinical JJ cord-005453-4057qib7 7258 10 trial trial NN cord-005453-4057qib7 7258 11 to to TO cord-005453-4057qib7 7258 12 assess assess VB cord-005453-4057qib7 7258 13 TCD TCD NNP cord-005453-4057qib7 7258 14 - - HYPH cord-005453-4057qib7 7258 15 haplo haplo NNP cord-005453-4057qib7 7258 16 - - HYPH cord-005453-4057qib7 7258 17 HSCT HSCT NNP cord-005453-4057qib7 7258 18 prospectively prospectively RB cord-005453-4057qib7 7258 19 which which WDT cord-005453-4057qib7 7258 20 aims aim VBZ cord-005453-4057qib7 7258 21 to to TO cord-005453-4057qib7 7258 22 demonstrate demonstrate VB cord-005453-4057qib7 7258 23 that that IN cord-005453-4057qib7 7258 24 a a DT cord-005453-4057qib7 7258 25 HSCT HSCT NNP cord-005453-4057qib7 7258 26 from from IN cord-005453-4057qib7 7258 27 a a DT cord-005453-4057qib7 7258 28 haploidentical haploidentical JJ cord-005453-4057qib7 7258 29 relative relative NN cord-005453-4057qib7 7258 30 is be VBZ cord-005453-4057qib7 7258 31 not not RB cord-005453-4057qib7 7258 32 inferior inferior JJ cord-005453-4057qib7 7258 33 to to IN cord-005453-4057qib7 7258 34 a a DT cord-005453-4057qib7 7258 35 MSD MSD NNP cord-005453-4057qib7 7258 36 HSCT HSCT NNP cord-005453-4057qib7 7258 37 with with IN cord-005453-4057qib7 7258 38 regard regard NN cord-005453-4057qib7 7258 39 to to IN cord-005453-4057qib7 7258 40 major major JJ cord-005453-4057qib7 7258 41 outcome outcome NN cord-005453-4057qib7 7258 42 parameter parameter NN cord-005453-4057qib7 7258 43 . . . cord-005453-4057qib7 7259 1 This this DT cord-005453-4057qib7 7259 2 phase phase NN cord-005453-4057qib7 7259 3 2 2 CD cord-005453-4057qib7 7259 4 , , , cord-005453-4057qib7 7259 5 prospective prospective JJ cord-005453-4057qib7 7259 6 , , , cord-005453-4057qib7 7259 7 stratified stratified JJ cord-005453-4057qib7 7259 8 , , , cord-005453-4057qib7 7259 9 open open JJ cord-005453-4057qib7 7259 10 - - HYPH cord-005453-4057qib7 7259 11 label label NN cord-005453-4057qib7 7259 12 study study NN cord-005453-4057qib7 7259 13 is be VBZ cord-005453-4057qib7 7259 14 targeting target VBG cord-005453-4057qib7 7259 15 enrollment enrollment NN cord-005453-4057qib7 7259 16 of of IN cord-005453-4057qib7 7259 17 212 212 CD cord-005453-4057qib7 7259 18 patients patient NNS cord-005453-4057qib7 7259 19 aged age VBN cord-005453-4057qib7 7259 20 1 1 CD cord-005453-4057qib7 7259 21 - - SYM cord-005453-4057qib7 7259 22 35 35 CD cord-005453-4057qib7 7259 23 years year NNS cord-005453-4057qib7 7259 24 with with IN cord-005453-4057qib7 7259 25 homozygous homozygous JJ cord-005453-4057qib7 7259 26 HbS hbs JJ cord-005453-4057qib7 7259 27 disease disease NN cord-005453-4057qib7 7259 28 or or CC cord-005453-4057qib7 7259 29 heterozygous heterozygous JJ cord-005453-4057qib7 7259 30 HbSC HbSC NNP cord-005453-4057qib7 7259 31 or or CC cord-005453-4057qib7 7259 32 HbS hbs NN cord-005453-4057qib7 7259 33 0/+ 0/+ . cord-005453-4057qib7 7260 1 ß ß LS cord-005453-4057qib7 7260 2 - - : cord-005453-4057qib7 7260 3 Thal Thal NNP cord-005453-4057qib7 7260 4 suffering suffer VBG cord-005453-4057qib7 7260 5 from from IN cord-005453-4057qib7 7260 6 severe severe JJ cord-005453-4057qib7 7260 7 or or CC cord-005453-4057qib7 7260 8 moderate moderate JJ cord-005453-4057qib7 7260 9 SCD SCD NNP cord-005453-4057qib7 7260 10 related relate VBN cord-005453-4057qib7 7260 11 complications complication NNS cord-005453-4057qib7 7260 12 . . . cord-005453-4057qib7 7261 1 Inclusion inclusion NN cord-005453-4057qib7 7261 2 criteria criterion NNS cord-005453-4057qib7 7261 3 are be VBP cord-005453-4057qib7 7261 4 clinically clinically RB cord-005453-4057qib7 7261 5 significant significant JJ cord-005453-4057qib7 7261 6 SCD SCD NNP cord-005453-4057qib7 7261 7 related relate VBN cord-005453-4057qib7 7261 8 complications complication NNS cord-005453-4057qib7 7261 9 such such JJ cord-005453-4057qib7 7261 10 as as IN cord-005453-4057qib7 7261 11 stroke stroke NN cord-005453-4057qib7 7261 12 , , , cord-005453-4057qib7 7261 13 silent silent JJ cord-005453-4057qib7 7261 14 crisis crisis NN cord-005453-4057qib7 7261 15 , , , cord-005453-4057qib7 7261 16 pathological pathological JJ cord-005453-4057qib7 7261 17 angio angio NN cord-005453-4057qib7 7261 18 - - HYPH cord-005453-4057qib7 7261 19 MRI MRI NNP cord-005453-4057qib7 7261 20 , , , cord-005453-4057qib7 7261 21 transcranial transcranial JJ cord-005453-4057qib7 7261 22 doppler doppler NN cord-005453-4057qib7 7261 23 ( ( -LRB- cord-005453-4057qib7 7261 24 TCD TCD NNP cord-005453-4057qib7 7261 25 ) ) -RRB- cord-005453-4057qib7 7261 26 velocity velocity NN cord-005453-4057qib7 7261 27 > > XX cord-005453-4057qib7 7261 28 200 200 CD cord-005453-4057qib7 7261 29 cm cm NNS cord-005453-4057qib7 7261 30 / / SYM cord-005453-4057qib7 7261 31 s s NN cord-005453-4057qib7 7261 32 , , , cord-005453-4057qib7 7261 33 2 2 CD cord-005453-4057qib7 7261 34 or or CC cord-005453-4057qib7 7261 35 more more JJR cord-005453-4057qib7 7261 36 episodes episode NNS cord-005453-4057qib7 7261 37 of of IN cord-005453-4057qib7 7261 38 acute acute JJ cord-005453-4057qib7 7261 39 chest chest NN cord-005453-4057qib7 7261 40 syndrome syndrome NN cord-005453-4057qib7 7261 41 ( ( -LRB- cord-005453-4057qib7 7261 42 ACS ACS NNP cord-005453-4057qib7 7261 43 ) ) -RRB- cord-005453-4057qib7 7261 44 in in IN cord-005453-4057qib7 7261 45 a a DT cord-005453-4057qib7 7261 46 lifetime lifetime NN cord-005453-4057qib7 7261 47 , , , cord-005453-4057qib7 7261 48 chronic chronic JJ cord-005453-4057qib7 7261 49 transfusion transfusion NN cord-005453-4057qib7 7261 50 dependency dependency NN cord-005453-4057qib7 7261 51 , , , cord-005453-4057qib7 7261 52 transfusion transfusion NN cord-005453-4057qib7 7261 53 - - HYPH cord-005453-4057qib7 7261 54 refractory refractory JJ cord-005453-4057qib7 7261 55 allo allo NN cord-005453-4057qib7 7261 56 - - HYPH cord-005453-4057qib7 7261 57 immunization immunization NN cord-005453-4057qib7 7261 58 and and CC cord-005453-4057qib7 7261 59 others other NNS cord-005453-4057qib7 7261 60 . . . cord-005453-4057qib7 7262 1 Pts Pts NNP cord-005453-4057qib7 7262 2 fulfilling fulfil VBG cord-005453-4057qib7 7262 3 inclusion inclusion NN cord-005453-4057qib7 7262 4 criteria criterion NNS cord-005453-4057qib7 7262 5 will will MD cord-005453-4057qib7 7262 6 be be VB cord-005453-4057qib7 7262 7 stratified stratify VBN cord-005453-4057qib7 7262 8 according accord VBG cord-005453-4057qib7 7262 9 to to IN cord-005453-4057qib7 7262 10 donor donor NN cord-005453-4057qib7 7262 11 availability availability NN cord-005453-4057qib7 7262 12 . . . cord-005453-4057qib7 7263 1 Pts Pts NNP cord-005453-4057qib7 7263 2 with with IN cord-005453-4057qib7 7263 3 a a DT cord-005453-4057qib7 7263 4 MSD MSD NNP cord-005453-4057qib7 7263 5 will will MD cord-005453-4057qib7 7263 6 receive receive VB cord-005453-4057qib7 7263 7 a a DT cord-005453-4057qib7 7263 8 bone bone NN cord-005453-4057qib7 7263 9 marrow marrow NN cord-005453-4057qib7 7263 10 graft graft NN cord-005453-4057qib7 7263 11 , , , cord-005453-4057qib7 7263 12 pts pts IN cord-005453-4057qib7 7263 13 requiring require VBG cord-005453-4057qib7 7263 14 an an DT cord-005453-4057qib7 7263 15 alternative alternative JJ cord-005453-4057qib7 7263 16 donor donor NN cord-005453-4057qib7 7263 17 will will MD cord-005453-4057qib7 7263 18 be be VB cord-005453-4057qib7 7263 19 transplanted transplant VBN cord-005453-4057qib7 7263 20 with with IN cord-005453-4057qib7 7263 21 an an DT cord-005453-4057qib7 7263 22 aß/ aß/ NN cord-005453-4057qib7 7264 1 CD19 CD19 NNP cord-005453-4057qib7 7264 2 depleted deplete VBD cord-005453-4057qib7 7264 3 graft graft NN cord-005453-4057qib7 7264 4 from from IN cord-005453-4057qib7 7264 5 a a DT cord-005453-4057qib7 7264 6 haploidentical haploidentical JJ cord-005453-4057qib7 7264 7 family family NN cord-005453-4057qib7 7264 8 donor donor NN cord-005453-4057qib7 7264 9 . . . cord-005453-4057qib7 7265 1 The the DT cord-005453-4057qib7 7265 2 conditioning conditioning NN cord-005453-4057qib7 7265 3 regimen regimen NN cord-005453-4057qib7 7265 4 for for IN cord-005453-4057qib7 7265 5 both both DT cord-005453-4057qib7 7265 6 groups group NNS cord-005453-4057qib7 7265 7 will will MD cord-005453-4057qib7 7265 8 be be VB cord-005453-4057qib7 7265 9 identical identical JJ cord-005453-4057qib7 7265 10 with with IN cord-005453-4057qib7 7265 11 the the DT cord-005453-4057qib7 7265 12 exception exception NN cord-005453-4057qib7 7265 13 that that IN cord-005453-4057qib7 7265 14 antithymoglobulin antithymoglobulin NNP cord-005453-4057qib7 7265 15 ( ( -LRB- cord-005453-4057qib7 7265 16 ATG ATG NNP cord-005453-4057qib7 7265 17 - - HYPH cord-005453-4057qib7 7265 18 Neovii Neovii NNP cord-005453-4057qib7 7265 19 ® ® . cord-005453-4057qib7 7265 20 ) ) -RRB- cord-005453-4057qib7 7265 21 is be VBZ cord-005453-4057qib7 7265 22 given give VBN cord-005453-4057qib7 7265 23 upfront upfront NN cord-005453-4057qib7 7265 24 in in IN cord-005453-4057qib7 7265 25 Thaplo Thaplo NNP cord-005453-4057qib7 7265 26 - - HYPH cord-005453-4057qib7 7265 27 HSCT HSCT NNP cord-005453-4057qib7 7265 28 versus versus IN cord-005453-4057qib7 7265 29 day day NN cord-005453-4057qib7 7265 30 -3 -3 NNP cord-005453-4057qib7 7265 31 to to IN cord-005453-4057qib7 7265 32 -1 -1 NN cord-005453-4057qib7 7265 33 in in IN cord-005453-4057qib7 7265 34 MSD MSD NNP cord-005453-4057qib7 7265 35 . . . cord-005453-4057qib7 7266 1 Chemotherapy chemotherapy NN cord-005453-4057qib7 7266 2 consists consist VBZ cord-005453-4057qib7 7266 3 of of IN cord-005453-4057qib7 7266 4 thiotepa thiotepa JJ cord-005453-4057qib7 7266 5 , , , cord-005453-4057qib7 7266 6 fludarabine fludarabine NN cord-005453-4057qib7 7266 7 and and CC cord-005453-4057qib7 7266 8 treosulfan treosulfan NNP cord-005453-4057qib7 7266 9 . . . cord-005453-4057qib7 7267 1 Posttransplant Posttransplant NNP cord-005453-4057qib7 7267 2 immunosuppression immunosuppression NN cord-005453-4057qib7 7267 3 will will MD cord-005453-4057qib7 7267 4 consist consist VB cord-005453-4057qib7 7267 5 of of IN cord-005453-4057qib7 7267 6 mofetil mofetil NNP cord-005453-4057qib7 7267 7 mycophenolate mycophenolate NNP cord-005453-4057qib7 7267 8 and and CC cord-005453-4057qib7 7267 9 tacrolimus tacrolimus NNP cord-005453-4057qib7 7267 10 for for IN cord-005453-4057qib7 7267 11 a a DT cord-005453-4057qib7 7267 12 duration duration NN cord-005453-4057qib7 7267 13 > > XX cord-005453-4057qib7 7267 14 6 6 CD cord-005453-4057qib7 7267 15 months month NNS cord-005453-4057qib7 7267 16 in in IN cord-005453-4057qib7 7267 17 T t NN cord-005453-4057qib7 7267 18 - - HYPH cord-005453-4057qib7 7267 19 haplo haplo NNP cord-005453-4057qib7 7267 20 - - HYPH cord-005453-4057qib7 7267 21 HSCT HSCT NNP cord-005453-4057qib7 7267 22 and and CC cord-005453-4057qib7 7267 23 < < NNP cord-005453-4057qib7 7267 24 6 6 CD cord-005453-4057qib7 7267 25 months month NNS cord-005453-4057qib7 7267 26 in in IN cord-005453-4057qib7 7267 27 MSD MSD NNP cord-005453-4057qib7 7267 28 , , , cord-005453-4057qib7 7267 29 depending depend VBG cord-005453-4057qib7 7267 30 on on IN cord-005453-4057qib7 7267 31 chimerism chimerism NN cord-005453-4057qib7 7267 32 . . . cord-005453-4057qib7 7268 1 ( ( -LRB- cord-005453-4057qib7 7268 2 EudraCT eudract JJ cord-005453-4057qib7 7268 3 number number NN cord-005453-4057qib7 7268 4 : : : cord-005453-4057qib7 7268 5 2018 2018 CD cord-005453-4057qib7 7268 6 - - HYPH cord-005453-4057qib7 7268 7 002652 002652 CD cord-005453-4057qib7 7268 8 - - SYM cord-005453-4057qib7 7268 9 33 33 CD cord-005453-4057qib7 7268 10 ) ) -RRB- cord-005453-4057qib7 7268 11 Results result NNS cord-005453-4057qib7 7268 12 : : : cord-005453-4057qib7 7268 13 Primary primary JJ cord-005453-4057qib7 7268 14 efficacy efficacy NN cord-005453-4057qib7 7268 15 endpoint endpoint NN cord-005453-4057qib7 7268 16 : : : cord-005453-4057qib7 7269 1 Event event NN cord-005453-4057qib7 7269 2 free free JJ cord-005453-4057qib7 7269 3 survival survival NN cord-005453-4057qib7 7269 4 ( ( -LRB- cord-005453-4057qib7 7269 5 EFS EFS NNP cord-005453-4057qib7 7269 6 ) ) -RRB- cord-005453-4057qib7 7269 7 . . . cord-005453-4057qib7 7270 1 Event event NN cord-005453-4057qib7 7270 2 is be VBZ cord-005453-4057qib7 7270 3 defined define VBN cord-005453-4057qib7 7270 4 as as IN cord-005453-4057qib7 7270 5 incidence incidence NN cord-005453-4057qib7 7270 6 of of IN cord-005453-4057qib7 7270 7 acute acute JJ cord-005453-4057qib7 7270 8 GvHD gvhd NN cord-005453-4057qib7 7270 9 , , , cord-005453-4057qib7 7270 10 grade grade NN cord-005453-4057qib7 7270 11 III III NNP cord-005453-4057qib7 7270 12 -IV -iv NN cord-005453-4057qib7 7270 13 , , , cord-005453-4057qib7 7270 14 chronic chronic JJ cord-005453-4057qib7 7270 15 GvHD gvhd NN cord-005453-4057qib7 7270 16 , , , cord-005453-4057qib7 7270 17 rejection rejection NN cord-005453-4057qib7 7270 18 ( ( -LRB- cord-005453-4057qib7 7270 19 graft graft NN cord-005453-4057qib7 7270 20 failure failure NN cord-005453-4057qib7 7270 21 ) ) -RRB- cord-005453-4057qib7 7270 22 or or CC cord-005453-4057qib7 7270 23 death death NN cord-005453-4057qib7 7270 24 ( ( -LRB- cord-005453-4057qib7 7270 25 for for IN cord-005453-4057qib7 7270 26 any any DT cord-005453-4057qib7 7270 27 reason reason NN cord-005453-4057qib7 7270 28 ) ) -RRB- cord-005453-4057qib7 7270 29 . . . cord-005453-4057qib7 7271 1 Key key JJ cord-005453-4057qib7 7271 2 secondary secondary JJ cord-005453-4057qib7 7271 3 endpoint(s endpoint(s NNP cord-005453-4057qib7 7271 4 ) ) -RRB- cord-005453-4057qib7 7271 5 are be VBP cord-005453-4057qib7 7271 6 OS OS NNP cord-005453-4057qib7 7271 7 , , , cord-005453-4057qib7 7271 8 DFS DFS NNP cord-005453-4057qib7 7271 9 , , , cord-005453-4057qib7 7271 10 graft graft NN cord-005453-4057qib7 7271 11 failure failure NN cord-005453-4057qib7 7271 12 , , , cord-005453-4057qib7 7271 13 hematological hematological JJ cord-005453-4057qib7 7271 14 and and CC cord-005453-4057qib7 7271 15 immunological immunological JJ cord-005453-4057qib7 7271 16 reconstitution reconstitution NN cord-005453-4057qib7 7271 17 , , , cord-005453-4057qib7 7271 18 quality quality NN cord-005453-4057qib7 7271 19 of of IN cord-005453-4057qib7 7271 20 life life NN cord-005453-4057qib7 7271 21 ( ( -LRB- cord-005453-4057qib7 7271 22 QOL QOL NNP cord-005453-4057qib7 7271 23 ) ) -RRB- cord-005453-4057qib7 7271 24 assessment assessment NN cord-005453-4057qib7 7271 25 and and CC cord-005453-4057qib7 7271 26 fertility fertility NN cord-005453-4057qib7 7271 27 . . . cord-005453-4057qib7 7272 1 The the DT cord-005453-4057qib7 7272 2 primary primary JJ cord-005453-4057qib7 7272 3 null null JJ cord-005453-4057qib7 7272 4 hypothesis hypothesis NN cord-005453-4057qib7 7272 5 is be VBZ cord-005453-4057qib7 7272 6 : : : cord-005453-4057qib7 7272 7 EFS EFS NNP cord-005453-4057qib7 7272 8 of of IN cord-005453-4057qib7 7272 9 SCD SCD NNP cord-005453-4057qib7 7272 10 patients patient NNS cord-005453-4057qib7 7272 11 treated treat VBN cord-005453-4057qib7 7272 12 with with IN cord-005453-4057qib7 7272 13 T T NNP cord-005453-4057qib7 7272 14 - - HYPH cord-005453-4057qib7 7272 15 Haplo Haplo NNP cord-005453-4057qib7 7272 16 - - HYPH cord-005453-4057qib7 7272 17 HSCT HSCT NNP cord-005453-4057qib7 7273 1 is be VBZ cord-005453-4057qib7 7273 2 non non JJ cord-005453-4057qib7 7273 3 - - JJ cord-005453-4057qib7 7273 4 relevantly relevantly RB cord-005453-4057qib7 7273 5 inferior inferior JJ cord-005453-4057qib7 7273 6 to to IN cord-005453-4057qib7 7273 7 EFS EFS NNP cord-005453-4057qib7 7273 8 in in IN cord-005453-4057qib7 7273 9 the the DT cord-005453-4057qib7 7273 10 MSD MSD NNP cord-005453-4057qib7 7273 11 arm arm NN cord-005453-4057qib7 7273 12 . . . cord-005453-4057qib7 7274 1 Conclusions conclusion NNS cord-005453-4057qib7 7274 2 : : : cord-005453-4057qib7 7275 1 Results result NNS cord-005453-4057qib7 7275 2 will will MD cord-005453-4057qib7 7275 3 help help VB cord-005453-4057qib7 7275 4 to to TO cord-005453-4057qib7 7275 5 determine determine VB cord-005453-4057qib7 7275 6 if if IN cord-005453-4057qib7 7275 7 an an DT cord-005453-4057qib7 7275 8 a a NN cord-005453-4057qib7 7275 9 / / SYM cord-005453-4057qib7 7275 10 ß ß NN cord-005453-4057qib7 7275 11 depleted deplete VBD cord-005453-4057qib7 7275 12 T T NNP cord-005453-4057qib7 7275 13 - - HYPH cord-005453-4057qib7 7275 14 haplo haplo NNP cord-005453-4057qib7 7275 15 - - HYPH cord-005453-4057qib7 7275 16 HSCT HSCT NNP cord-005453-4057qib7 7275 17 can can MD cord-005453-4057qib7 7275 18 be be VB cord-005453-4057qib7 7275 19 considered consider VBN cord-005453-4057qib7 7275 20 equivalent equivalent JJ cord-005453-4057qib7 7275 21 to to IN cord-005453-4057qib7 7275 22 MSD MSD NNP cord-005453-4057qib7 7275 23 HSCT HSCT NNP cord-005453-4057qib7 7275 24 with with IN cord-005453-4057qib7 7275 25 regard regard NN cord-005453-4057qib7 7275 26 to to IN cord-005453-4057qib7 7275 27 DFS DFS NNP cord-005453-4057qib7 7275 28 , , , cord-005453-4057qib7 7275 29 adverse adverse JJ cord-005453-4057qib7 7275 30 events event NNS cord-005453-4057qib7 7275 31 and and CC cord-005453-4057qib7 7275 32 safety safety NN cord-005453-4057qib7 7275 33 , , , cord-005453-4057qib7 7275 34 in in IN cord-005453-4057qib7 7275 35 order order NN cord-005453-4057qib7 7275 36 to to TO cord-005453-4057qib7 7275 37 offer offer VB cord-005453-4057qib7 7275 38 this this DT cord-005453-4057qib7 7275 39 form form NN cord-005453-4057qib7 7275 40 of of IN cord-005453-4057qib7 7275 41 cure cure NN cord-005453-4057qib7 7275 42 to to IN cord-005453-4057qib7 7275 43 the the DT cord-005453-4057qib7 7275 44 majority majority NN cord-005453-4057qib7 7275 45 of of IN cord-005453-4057qib7 7275 46 patients patient NNS cord-005453-4057qib7 7275 47 with with IN cord-005453-4057qib7 7275 48 SCD SCD NNP cord-005453-4057qib7 7275 49 . . . cord-005453-4057qib7 7276 1 Disclosure disclosure NN cord-005453-4057qib7 7276 2 : : : cord-005453-4057qib7 7276 3 Nothing nothing NN cord-005453-4057qib7 7276 4 to to TO cord-005453-4057qib7 7276 5 declare declare VB cord-005453-4057qib7 7276 6 Hit Hit VBN cord-005453-4057qib7 7276 7 three three CD cord-005453-4057qib7 7276 8 birds bird NNS cord-005453-4057qib7 7276 9 with with IN cord-005453-4057qib7 7276 10 one one CD cord-005453-4057qib7 7276 11 stone stone NN cord-005453-4057qib7 7276 12 : : : cord-005453-4057qib7 7276 13 Successful successful JJ cord-005453-4057qib7 7276 14 stem stem NN cord-005453-4057qib7 7276 15 cell cell NN cord-005453-4057qib7 7276 16 transplantation transplantation NN cord-005453-4057qib7 7276 17 from from IN cord-005453-4057qib7 7276 18 one one CD cord-005453-4057qib7 7276 19 family family NN cord-005453-4057qib7 7276 20 donor donor NN cord-005453-4057qib7 7276 21 to to IN cord-005453-4057qib7 7276 22 three three CD cord-005453-4057qib7 7276 23 siblings sibling NNS cord-005453-4057qib7 7276 24 Methods method NNS cord-005453-4057qib7 7276 25 : : : cord-005453-4057qib7 7276 26 In in IN cord-005453-4057qib7 7276 27 August August NNP cord-005453-4057qib7 7276 28 2016 2016 CD cord-005453-4057qib7 7276 29 , , , cord-005453-4057qib7 7276 30 three three CD cord-005453-4057qib7 7276 31 thalassemic thalassemic NNP cord-005453-4057qib7 7276 32 siblings sibling NNS cord-005453-4057qib7 7276 33 were be VBD cord-005453-4057qib7 7276 34 admitted admit VBN cord-005453-4057qib7 7276 35 to to IN cord-005453-4057qib7 7276 36 hospital hospital NN cord-005453-4057qib7 7276 37 for for IN cord-005453-4057qib7 7276 38 stem stem NN cord-005453-4057qib7 7276 39 cell cell NN cord-005453-4057qib7 7276 40 transplantation transplantation NN cord-005453-4057qib7 7276 41 from from IN cord-005453-4057qib7 7276 42 a a DT cord-005453-4057qib7 7276 43 full full JJ cord-005453-4057qib7 7276 44 match match NN cord-005453-4057qib7 7276 45 donor donor NN cord-005453-4057qib7 7276 46 , , , cord-005453-4057qib7 7276 47 their -PRON- PRP$ cord-005453-4057qib7 7276 48 17 17 CD cord-005453-4057qib7 7276 49 years year NNS cord-005453-4057qib7 7276 50 old old JJ cord-005453-4057qib7 7276 51 sister sister NN cord-005453-4057qib7 7276 52 . . . cord-005453-4057qib7 7277 1 The the DT cord-005453-4057qib7 7277 2 patients patient NNS cord-005453-4057qib7 7277 3 ' ' POS cord-005453-4057qib7 7277 4 general general JJ cord-005453-4057qib7 7277 5 health health NN cord-005453-4057qib7 7277 6 conditions condition NNS cord-005453-4057qib7 7277 7 and and CC cord-005453-4057qib7 7277 8 specific specific JJ cord-005453-4057qib7 7277 9 health health NN cord-005453-4057qib7 7277 10 issues issue NNS cord-005453-4057qib7 7277 11 due due JJ cord-005453-4057qib7 7277 12 to to IN cord-005453-4057qib7 7277 13 thalassemia thalassemia NN cord-005453-4057qib7 7277 14 were be VBD cord-005453-4057qib7 7277 15 checked check VBN cord-005453-4057qib7 7277 16 extensively extensively RB cord-005453-4057qib7 7277 17 . . . cord-005453-4057qib7 7278 1 It -PRON- PRP cord-005453-4057qib7 7278 2 was be VBD cord-005453-4057qib7 7278 3 decided decide VBN cord-005453-4057qib7 7278 4 to to TO cord-005453-4057qib7 7278 5 perform perform VB cord-005453-4057qib7 7278 6 first first JJ cord-005453-4057qib7 7278 7 transplant transplant NN cord-005453-4057qib7 7278 8 to to IN cord-005453-4057qib7 7278 9 older old JJR cord-005453-4057qib7 7278 10 sister sister NN cord-005453-4057qib7 7278 11 whom whom WP cord-005453-4057qib7 7278 12 the the DT cord-005453-4057qib7 7278 13 disease disease NN cord-005453-4057qib7 7278 14 and and CC cord-005453-4057qib7 7278 15 transplant transplant NN cord-005453-4057qib7 7278 16 complications complication NNS cord-005453-4057qib7 7278 17 are be VBP cord-005453-4057qib7 7278 18 expected expect VBN cord-005453-4057qib7 7278 19 more more RBR cord-005453-4057qib7 7278 20 intense intense JJ cord-005453-4057qib7 7278 21 due due IN cord-005453-4057qib7 7278 22 to to IN cord-005453-4057qib7 7278 23 prolonged prolong VBN cord-005453-4057qib7 7278 24 transfusion transfusion NN cord-005453-4057qib7 7278 25 and and CC cord-005453-4057qib7 7278 26 chelation chelation NN cord-005453-4057qib7 7278 27 therapy therapy NN cord-005453-4057qib7 7278 28 . . . cord-005453-4057qib7 7279 1 The the DT cord-005453-4057qib7 7279 2 oldest old JJS cord-005453-4057qib7 7279 3 daughter daughter NN cord-005453-4057qib7 7279 4 of of IN cord-005453-4057qib7 7279 5 family family NN cord-005453-4057qib7 7279 6 , , , cord-005453-4057qib7 7279 7 healthy healthy JJ cord-005453-4057qib7 7279 8 , , , cord-005453-4057qib7 7279 9 was be VBD cord-005453-4057qib7 7279 10 planned plan VBN cord-005453-4057qib7 7279 11 to to TO cord-005453-4057qib7 7279 12 accompany accompany VB cord-005453-4057qib7 7279 13 her -PRON- PRP$ cord-005453-4057qib7 7279 14 sisters sister NNS cord-005453-4057qib7 7279 15 in in IN cord-005453-4057qib7 7279 16 transplantation transplantation NN cord-005453-4057qib7 7279 17 unit unit NN cord-005453-4057qib7 7279 18 so so IN cord-005453-4057qib7 7279 19 parents parent NNS cord-005453-4057qib7 7279 20 can can MD cord-005453-4057qib7 7279 21 take take VB cord-005453-4057qib7 7279 22 care care VB cord-005453-4057qib7 7279 23 the the DT cord-005453-4057qib7 7279 24 others other NNS cord-005453-4057qib7 7279 25 and and CC cord-005453-4057qib7 7279 26 organize organize VB cord-005453-4057qib7 7279 27 this this DT cord-005453-4057qib7 7279 28 period period NN cord-005453-4057qib7 7279 29 for for IN cord-005453-4057qib7 7279 30 whole whole JJ cord-005453-4057qib7 7279 31 family family NN cord-005453-4057qib7 7279 32 . . . cord-005453-4057qib7 7280 1 Results result NNS cord-005453-4057qib7 7280 2 : : : cord-005453-4057qib7 7281 1 The the DT cord-005453-4057qib7 7281 2 13 13 CD cord-005453-4057qib7 7281 3 years year NNS cord-005453-4057qib7 7281 4 old old JJ cord-005453-4057qib7 7281 5 sibling sibling NN cord-005453-4057qib7 7281 6 was be VBD cord-005453-4057qib7 7281 7 first first RB cord-005453-4057qib7 7281 8 admitted admit VBN cord-005453-4057qib7 7281 9 to to IN cord-005453-4057qib7 7281 10 bone bone NN cord-005453-4057qib7 7281 11 marrow marrow NN cord-005453-4057qib7 7281 12 transplantation transplantation NN cord-005453-4057qib7 7281 13 unit unit NN cord-005453-4057qib7 7281 14 in in IN cord-005453-4057qib7 7281 15 July July NNP cord-005453-4057qib7 7281 16 2017 2017 CD cord-005453-4057qib7 7281 17 . . . cord-005453-4057qib7 7282 1 The the DT cord-005453-4057qib7 7282 2 conditioning conditioning NN cord-005453-4057qib7 7282 3 regimen regimen NN cord-005453-4057qib7 7282 4 was be VBD cord-005453-4057qib7 7282 5 busulfan busulfan NN cord-005453-4057qib7 7282 6 , , , cord-005453-4057qib7 7282 7 fludarabine fludarabine NN cord-005453-4057qib7 7282 8 , , , cord-005453-4057qib7 7282 9 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 7282 10 and and CC cord-005453-4057qib7 7282 11 thiotepa thiotepa NNS cord-005453-4057qib7 7282 12 with with IN cord-005453-4057qib7 7282 13 Antithymocyteglobulin(ATG Antithymocyteglobulin(ATG NNP cord-005453-4057qib7 7282 14 ) ) -RRB- cord-005453-4057qib7 7282 15 and and CC cord-005453-4057qib7 7282 16 defibrotide defibrotide NNP cord-005453-4057qib7 7282 17 prophylaxis prophylaxis NNP cord-005453-4057qib7 7282 18 was be VBD cord-005453-4057qib7 7282 19 given give VBN cord-005453-4057qib7 7282 20 . . . cord-005453-4057qib7 7283 1 The the DT cord-005453-4057qib7 7283 2 healthy healthy JJ cord-005453-4057qib7 7283 3 donor donor NN cord-005453-4057qib7 7283 4 was be VBD cord-005453-4057qib7 7283 5 admitted admit VBN cord-005453-4057qib7 7283 6 to to IN cord-005453-4057qib7 7283 7 hospital hospital NN cord-005453-4057qib7 7283 8 and and CC cord-005453-4057qib7 7283 9 received receive VBD cord-005453-4057qib7 7283 10 G G NNP cord-005453-4057qib7 7283 11 - - HYPH cord-005453-4057qib7 7283 12 CSF CSF NNP cord-005453-4057qib7 7283 13 for for IN cord-005453-4057qib7 7283 14 5 5 CD cord-005453-4057qib7 7283 15 continuous continuous JJ cord-005453-4057qib7 7283 16 days day NNS cord-005453-4057qib7 7283 17 before before IN cord-005453-4057qib7 7283 18 harvesting harvest VBG cord-005453-4057qib7 7283 19 . . . cord-005453-4057qib7 7284 1 Stem stem NN cord-005453-4057qib7 7284 2 cells cell NNS cord-005453-4057qib7 7284 3 were be VBD cord-005453-4057qib7 7284 4 collected collect VBN cord-005453-4057qib7 7284 5 peripherally peripherally RB cord-005453-4057qib7 7284 6 on on IN cord-005453-4057qib7 7284 7 day day NN cord-005453-4057qib7 7284 8 0 0 CD cord-005453-4057qib7 7284 9 and and CC cord-005453-4057qib7 7284 10 viable viable JJ cord-005453-4057qib7 7284 11 CD34 CD34 NNP cord-005453-4057qib7 7285 1 + + CC cord-005453-4057qib7 7285 2 cells cell NNS cord-005453-4057qib7 7285 3 were be VBD cord-005453-4057qib7 7286 1 2211 2211 CD cord-005453-4057qib7 7286 2 / / SYM cord-005453-4057qib7 7286 3 uL. ul. JJ cord-005453-4057qib7 7286 4 Patient Patient NNP cord-005453-4057qib7 7286 5 received receive VBD cord-005453-4057qib7 7286 6 5,5 5,5 CD cord-005453-4057qib7 7286 7 x10e6 x10e6 NNP cord-005453-4057qib7 7286 8 / / SYM cord-005453-4057qib7 7286 9 kg kg CD cord-005453-4057qib7 7286 10 stem stem NN cord-005453-4057qib7 7286 11 cell cell NN cord-005453-4057qib7 7286 12 and and CC cord-005453-4057qib7 7286 13 the the DT cord-005453-4057qib7 7286 14 other other JJ cord-005453-4057qib7 7286 15 cell cell NN cord-005453-4057qib7 7286 16 products product NNS cord-005453-4057qib7 7286 17 were be VBD cord-005453-4057qib7 7286 18 divided divide VBN cord-005453-4057qib7 7286 19 into into IN cord-005453-4057qib7 7286 20 4 4 CD cord-005453-4057qib7 7286 21 parts part NNS cord-005453-4057qib7 7286 22 according accord VBG cord-005453-4057qib7 7286 23 to to IN cord-005453-4057qib7 7286 24 other other JJ cord-005453-4057qib7 7286 25 recipients´weight recipients´weight CD cord-005453-4057qib7 7286 26 . . . cord-005453-4057qib7 7287 1 No no DT cord-005453-4057qib7 7287 2 infusion infusion NN cord-005453-4057qib7 7287 3 problems problem NNS cord-005453-4057qib7 7287 4 were be VBD cord-005453-4057qib7 7287 5 recorded record VBN cord-005453-4057qib7 7287 6 in in IN cord-005453-4057qib7 7287 7 stem stem NN cord-005453-4057qib7 7287 8 cell cell NN cord-005453-4057qib7 7287 9 transfusion transfusion NN cord-005453-4057qib7 7287 10 . . . cord-005453-4057qib7 7288 1 GVHD GVHD NNP cord-005453-4057qib7 7288 2 prophylaxis prophylaxis NN cord-005453-4057qib7 7288 3 was be VBD cord-005453-4057qib7 7288 4 given give VBN cord-005453-4057qib7 7288 5 with with IN cord-005453-4057qib7 7288 6 cyclosporin cyclosporin NN cord-005453-4057qib7 7288 7 and and CC cord-005453-4057qib7 7288 8 methotrexate methotrexate NNP cord-005453-4057qib7 7288 9 . . . cord-005453-4057qib7 7289 1 Severe severe JJ cord-005453-4057qib7 7289 2 sinusoidal sinusoidal JJ cord-005453-4057qib7 7289 3 obstruction obstruction NN cord-005453-4057qib7 7289 4 syndrome syndrome NN cord-005453-4057qib7 7289 5 was be VBD cord-005453-4057qib7 7289 6 observed observe VBN cord-005453-4057qib7 7289 7 and and CC cord-005453-4057qib7 7289 8 successfully successfully RB cord-005453-4057qib7 7289 9 managed manage VBN cord-005453-4057qib7 7289 10 with with IN cord-005453-4057qib7 7289 11 supportive supportive JJ cord-005453-4057qib7 7289 12 therapy therapy NN cord-005453-4057qib7 7289 13 . . . cord-005453-4057qib7 7290 1 Neutrophils neutrophil NNS cord-005453-4057qib7 7290 2 were be VBD cord-005453-4057qib7 7290 3 engrafted engraft VBN cord-005453-4057qib7 7290 4 +11 +11 CD cord-005453-4057qib7 7290 5 . . . cord-005453-4057qib7 7291 1 day day NN cord-005453-4057qib7 7291 2 , , , cord-005453-4057qib7 7291 3 and and CC cord-005453-4057qib7 7291 4 platelets platelet NNS cord-005453-4057qib7 7291 5 were be VBD cord-005453-4057qib7 7291 6 on on IN cord-005453-4057qib7 7291 7 day day NN cord-005453-4057qib7 7291 8 64 64 CD cord-005453-4057qib7 7291 9 . . . cord-005453-4057qib7 7292 1 Full full JJ cord-005453-4057qib7 7292 2 blood blood NN cord-005453-4057qib7 7292 3 chimerism chimerism NN cord-005453-4057qib7 7292 4 results result NNS cord-005453-4057qib7 7292 5 were be VBD cord-005453-4057qib7 7292 6 % % NN cord-005453-4057qib7 7292 7 98 98 CD cord-005453-4057qib7 7292 8 in in IN cord-005453-4057qib7 7292 9 day day NN cord-005453-4057qib7 7292 10 30 30 CD cord-005453-4057qib7 7292 11 , , , cord-005453-4057qib7 7292 12 % % NN cord-005453-4057qib7 7292 13 99 99 CD cord-005453-4057qib7 7292 14 in in IN cord-005453-4057qib7 7292 15 day day NN cord-005453-4057qib7 7292 16 60 60 CD cord-005453-4057qib7 7292 17 and and CC cord-005453-4057qib7 7292 18 % % NN cord-005453-4057qib7 7292 19 98 98 CD cord-005453-4057qib7 7292 20 in in IN cord-005453-4057qib7 7292 21 day day NN cord-005453-4057qib7 7292 22 180 180 CD cord-005453-4057qib7 7292 23 consecutively consecutively RB cord-005453-4057qib7 7292 24 . . . cord-005453-4057qib7 7293 1 After after IN cord-005453-4057qib7 7293 2 3 3 CD cord-005453-4057qib7 7293 3 months month NNS cord-005453-4057qib7 7293 4 from from IN cord-005453-4057qib7 7293 5 first first JJ cord-005453-4057qib7 7293 6 transplant transplant NN cord-005453-4057qib7 7293 7 the the DT cord-005453-4057qib7 7293 8 4 4 CD cord-005453-4057qib7 7293 9 years year NNS cord-005453-4057qib7 7293 10 old old JJ cord-005453-4057qib7 7293 11 sister sister NN cord-005453-4057qib7 7293 12 was be VBD cord-005453-4057qib7 7293 13 admitted admit VBN cord-005453-4057qib7 7293 14 to to IN cord-005453-4057qib7 7293 15 hospital hospital NN cord-005453-4057qib7 7293 16 on on IN cord-005453-4057qib7 7293 17 October October NNP cord-005453-4057qib7 7293 18 2017 2017 CD cord-005453-4057qib7 7293 19 . . . cord-005453-4057qib7 7294 1 Same same JJ cord-005453-4057qib7 7294 2 conditioning conditioning NN cord-005453-4057qib7 7294 3 with with IN cord-005453-4057qib7 7294 4 defibrotide defibrotide NN cord-005453-4057qib7 7294 5 prophylaxis prophylaxis NN cord-005453-4057qib7 7294 6 and and CC cord-005453-4057qib7 7294 7 GVHD GVHD NNP cord-005453-4057qib7 7294 8 prophylaxis prophylaxis NN cord-005453-4057qib7 7294 9 were be VBD cord-005453-4057qib7 7294 10 given give VBN cord-005453-4057qib7 7294 11 and and CC cord-005453-4057qib7 7294 12 6,8 6,8 CD cord-005453-4057qib7 7295 1 x10e6 x10e6 NNP cord-005453-4057qib7 7295 2 / / SYM cord-005453-4057qib7 7295 3 kg kg NNS cord-005453-4057qib7 7295 4 peripherally peripherally RB cord-005453-4057qib7 7295 5 derived derive VBN cord-005453-4057qib7 7295 6 and and CC cord-005453-4057qib7 7295 7 previously previously RB cord-005453-4057qib7 7295 8 frost frost VB cord-005453-4057qib7 7295 9 stem stem NN cord-005453-4057qib7 7295 10 cell cell NN cord-005453-4057qib7 7295 11 was be VBD cord-005453-4057qib7 7295 12 infused infuse VBN cord-005453-4057qib7 7295 13 without without IN cord-005453-4057qib7 7295 14 any any DT cord-005453-4057qib7 7295 15 complications complication NNS cord-005453-4057qib7 7295 16 . . . cord-005453-4057qib7 7296 1 Mild mild JJ cord-005453-4057qib7 7296 2 sinusoidal sinusoidal JJ cord-005453-4057qib7 7296 3 obstruction obstruction NN cord-005453-4057qib7 7296 4 syndrome syndrome NN cord-005453-4057qib7 7296 5 was be VBD cord-005453-4057qib7 7296 6 observed observe VBN cord-005453-4057qib7 7296 7 and and CC cord-005453-4057qib7 7296 8 managed manage VBN cord-005453-4057qib7 7296 9 with with IN cord-005453-4057qib7 7296 10 supportive supportive JJ cord-005453-4057qib7 7296 11 therapy therapy NN cord-005453-4057qib7 7296 12 successfully successfully RB cord-005453-4057qib7 7296 13 . . . cord-005453-4057qib7 7297 1 Neutrophils neutrophil NNS cord-005453-4057qib7 7297 2 were be VBD cord-005453-4057qib7 7297 3 engrafted engraft VBN cord-005453-4057qib7 7297 4 +11 +11 CD cord-005453-4057qib7 7297 5 . . . cord-005453-4057qib7 7298 1 day day NN cord-005453-4057qib7 7298 2 , , , cord-005453-4057qib7 7298 3 and and CC cord-005453-4057qib7 7298 4 platelets platelet NNS cord-005453-4057qib7 7298 5 were be VBD cord-005453-4057qib7 7298 6 on on IN cord-005453-4057qib7 7298 7 day day NN cord-005453-4057qib7 7298 8 16 16 CD cord-005453-4057qib7 7298 9 . . . cord-005453-4057qib7 7299 1 Full full JJ cord-005453-4057qib7 7299 2 blood blood NN cord-005453-4057qib7 7299 3 chimerism chimerism NN cord-005453-4057qib7 7299 4 results result NNS cord-005453-4057qib7 7299 5 were be VBD cord-005453-4057qib7 7299 6 % % NN cord-005453-4057qib7 7299 7 99 99 CD cord-005453-4057qib7 7299 8 in in IN cord-005453-4057qib7 7299 9 day day NN cord-005453-4057qib7 7299 10 30 30 CD cord-005453-4057qib7 7299 11 , , , cord-005453-4057qib7 7299 12 % % NN cord-005453-4057qib7 7299 13 99 99 CD cord-005453-4057qib7 7299 14 in in IN cord-005453-4057qib7 7299 15 day day NN cord-005453-4057qib7 7299 16 60 60 CD cord-005453-4057qib7 7299 17 and and CC cord-005453-4057qib7 7299 18 % % NN cord-005453-4057qib7 7299 19 99 99 CD cord-005453-4057qib7 7299 20 in in IN cord-005453-4057qib7 7299 21 day day NN cord-005453-4057qib7 7299 22 180 180 CD cord-005453-4057qib7 7299 23 consecutively consecutively RB cord-005453-4057qib7 7299 24 . . . cord-005453-4057qib7 7300 1 The the DT cord-005453-4057qib7 7300 2 third third JJ cord-005453-4057qib7 7300 3 transplant transplant NN cord-005453-4057qib7 7300 4 was be VBD cord-005453-4057qib7 7300 5 performed perform VBN cord-005453-4057qib7 7300 6 on on IN cord-005453-4057qib7 7300 7 January January NNP cord-005453-4057qib7 7300 8 2018 2018 CD cord-005453-4057qib7 7300 9 with with IN cord-005453-4057qib7 7300 10 the the DT cord-005453-4057qib7 7300 11 same same JJ cord-005453-4057qib7 7300 12 conditioning conditioning NN cord-005453-4057qib7 7300 13 and and CC cord-005453-4057qib7 7300 14 prophylaxis prophylaxis NN cord-005453-4057qib7 7300 15 regimen regimen NN cord-005453-4057qib7 7300 16 . . . cord-005453-4057qib7 7301 1 Although although IN cord-005453-4057qib7 7301 2 defibrotide defibrotide NN cord-005453-4057qib7 7301 3 was be VBD cord-005453-4057qib7 7301 4 used use VBN cord-005453-4057qib7 7301 5 mild mild JJ cord-005453-4057qib7 7301 6 SOS SOS NNP cord-005453-4057qib7 7301 7 was be VBD cord-005453-4057qib7 7301 8 observed observe VBN cord-005453-4057qib7 7301 9 and and CC cord-005453-4057qib7 7301 10 treated treat VBN cord-005453-4057qib7 7301 11 with with IN cord-005453-4057qib7 7301 12 supportive supportive JJ cord-005453-4057qib7 7301 13 therapy therapy NN cord-005453-4057qib7 7301 14 with with IN cord-005453-4057qib7 7301 15 success success NN cord-005453-4057qib7 7301 16 . . . cord-005453-4057qib7 7302 1 Neutrophils neutrophil NNS cord-005453-4057qib7 7302 2 were be VBD cord-005453-4057qib7 7302 3 engrafted engraft VBN cord-005453-4057qib7 7302 4 +10 +10 CD cord-005453-4057qib7 7302 5 . . . cord-005453-4057qib7 7303 1 Day day NN cord-005453-4057qib7 7303 2 , , , cord-005453-4057qib7 7303 3 and and CC cord-005453-4057qib7 7303 4 platelets platelet NNS cord-005453-4057qib7 7303 5 were be VBD cord-005453-4057qib7 7303 6 on on IN cord-005453-4057qib7 7303 7 day day NN cord-005453-4057qib7 7303 8 27 27 CD cord-005453-4057qib7 7303 9 . . . cord-005453-4057qib7 7304 1 Full full JJ cord-005453-4057qib7 7304 2 blood blood NN cord-005453-4057qib7 7304 3 chimerism chimerism NN cord-005453-4057qib7 7304 4 results result NNS cord-005453-4057qib7 7304 5 were be VBD cord-005453-4057qib7 7304 6 % % NN cord-005453-4057qib7 7304 7 99 99 CD cord-005453-4057qib7 7304 8 in in IN cord-005453-4057qib7 7304 9 day day NN cord-005453-4057qib7 7304 10 30 30 CD cord-005453-4057qib7 7304 11 , , , cord-005453-4057qib7 7304 12 % % NN cord-005453-4057qib7 7304 13 99 99 CD cord-005453-4057qib7 7304 14 in in IN cord-005453-4057qib7 7304 15 day day NN cord-005453-4057qib7 7304 16 60 60 CD cord-005453-4057qib7 7304 17 and and CC cord-005453-4057qib7 7304 18 % % NN cord-005453-4057qib7 7304 19 99 99 CD cord-005453-4057qib7 7304 20 in in IN cord-005453-4057qib7 7304 21 day day NN cord-005453-4057qib7 7304 22 180 180 CD cord-005453-4057qib7 7304 23 consecutively consecutively RB cord-005453-4057qib7 7304 24 . . . cord-005453-4057qib7 7305 1 Conclusions conclusion NNS cord-005453-4057qib7 7305 2 : : : cord-005453-4057qib7 7306 1 The the DT cord-005453-4057qib7 7306 2 patients patient NNS cord-005453-4057qib7 7306 3 are be VBP cord-005453-4057qib7 7306 4 being be VBG cord-005453-4057qib7 7306 5 followed follow VBN cord-005453-4057qib7 7306 6 for for IN cord-005453-4057qib7 7306 7 over over IN cord-005453-4057qib7 7306 8 a a DT cord-005453-4057qib7 7306 9 year year NN cord-005453-4057qib7 7306 10 after after IN cord-005453-4057qib7 7306 11 first first JJ cord-005453-4057qib7 7306 12 transplat transplat NNP cord-005453-4057qib7 7306 13 , , , cord-005453-4057qib7 7306 14 neither neither CC cord-005453-4057qib7 7306 15 adverse adverse JJ cord-005453-4057qib7 7306 16 nor nor CC cord-005453-4057qib7 7306 17 GVHD gvhd JJ cord-005453-4057qib7 7306 18 symptoms symptom NNS cord-005453-4057qib7 7306 19 were be VBD cord-005453-4057qib7 7306 20 observed observe VBN cord-005453-4057qib7 7306 21 . . . cord-005453-4057qib7 7307 1 We -PRON- PRP cord-005453-4057qib7 7307 2 presented present VBD cord-005453-4057qib7 7307 3 this this DT cord-005453-4057qib7 7307 4 case case NN cord-005453-4057qib7 7307 5 for for IN cord-005453-4057qib7 7307 6 being be VBG cord-005453-4057qib7 7307 7 a a DT cord-005453-4057qib7 7307 8 unique unique JJ cord-005453-4057qib7 7307 9 example example NN cord-005453-4057qib7 7307 10 for for IN cord-005453-4057qib7 7307 11 match match NN cord-005453-4057qib7 7307 12 family family NN cord-005453-4057qib7 7307 13 donor donor NN cord-005453-4057qib7 7307 14 transplant transplant NN cord-005453-4057qib7 7307 15 and and CC cord-005453-4057qib7 7307 16 the the DT cord-005453-4057qib7 7307 17 first first JJ cord-005453-4057qib7 7307 18 successful successful JJ cord-005453-4057qib7 7307 19 example example NN cord-005453-4057qib7 7307 20 from from IN cord-005453-4057qib7 7307 21 one one CD cord-005453-4057qib7 7307 22 donor donor NN cord-005453-4057qib7 7307 23 to to IN cord-005453-4057qib7 7307 24 three three CD cord-005453-4057qib7 7307 25 recipients recipient NNS cord-005453-4057qib7 7307 26 . . . cord-005453-4057qib7 7308 1 Disclosure disclosure NN cord-005453-4057qib7 7308 2 : : : cord-005453-4057qib7 7308 3 Nothing nothing NN cord-005453-4057qib7 7308 4 to to TO cord-005453-4057qib7 7308 5 declare declare VB cord-005453-4057qib7 7308 6 Results result NNS cord-005453-4057qib7 7308 7 : : : cord-005453-4057qib7 7309 1 Our -PRON- PRP$ cord-005453-4057qib7 7309 2 female female JJ cord-005453-4057qib7 7309 3 patient patient NN cord-005453-4057qib7 7309 4 admitted admit VBN cord-005453-4057qib7 7309 5 for for IN cord-005453-4057qib7 7309 6 anemia anemia NN cord-005453-4057qib7 7309 7 at at IN cord-005453-4057qib7 7309 8 3 3 CD cord-005453-4057qib7 7309 9 rd rd NNP cord-005453-4057qib7 7309 10 month month NN cord-005453-4057qib7 7309 11 of of IN cord-005453-4057qib7 7309 12 birth birth NN cord-005453-4057qib7 7309 13 and and CC cord-005453-4057qib7 7309 14 was be VBD cord-005453-4057qib7 7309 15 transfused transfuse VBN cord-005453-4057qib7 7309 16 every every DT cord-005453-4057qib7 7309 17 4 4 CD cord-005453-4057qib7 7309 18 - - SYM cord-005453-4057qib7 7309 19 5 5 CD cord-005453-4057qib7 7309 20 months month NNS cord-005453-4057qib7 7309 21 from from IN cord-005453-4057qib7 7309 22 6 6 CD cord-005453-4057qib7 7309 23 th th CD cord-005453-4057qib7 7309 24 months month NNS cord-005453-4057qib7 7309 25 to to IN cord-005453-4057qib7 7309 26 3.5 3.5 CD cord-005453-4057qib7 7309 27 years year NNS cord-005453-4057qib7 7309 28 of of IN cord-005453-4057qib7 7309 29 age age NN cord-005453-4057qib7 7309 30 . . . cord-005453-4057qib7 7310 1 Since since IN cord-005453-4057qib7 7310 2 investigations investigation NNS cord-005453-4057qib7 7310 3 directed direct VBN cord-005453-4057qib7 7310 4 towards towards IN cord-005453-4057qib7 7310 5 hemoglobinopathies hemoglobinopathy NNS cord-005453-4057qib7 7310 6 or or CC cord-005453-4057qib7 7310 7 membrane membrane NN cord-005453-4057qib7 7310 8 defects defect NNS cord-005453-4057qib7 7310 9 like like IN cord-005453-4057qib7 7310 10 hereditary hereditary JJ cord-005453-4057qib7 7310 11 spherocytosis spherocytosis NN cord-005453-4057qib7 7310 12 were be VBD cord-005453-4057qib7 7310 13 unremarkable unremarkable JJ cord-005453-4057qib7 7310 14 , , , cord-005453-4057qib7 7310 15 she -PRON- PRP cord-005453-4057qib7 7310 16 was be VBD cord-005453-4057qib7 7310 17 not not RB cord-005453-4057qib7 7310 18 transfused transfuse VBN cord-005453-4057qib7 7310 19 for for IN cord-005453-4057qib7 7310 20 6 6 CD cord-005453-4057qib7 7310 21 years year NNS cord-005453-4057qib7 7310 22 after after IN cord-005453-4057qib7 7310 23 the the DT cord-005453-4057qib7 7310 24 age age NN cord-005453-4057qib7 7310 25 of of IN cord-005453-4057qib7 7310 26 3.5-years 3.5-years CD cord-005453-4057qib7 7310 27 because because IN cord-005453-4057qib7 7310 28 hemoglobin hemoglobin NN cord-005453-4057qib7 7310 29 level level NN cord-005453-4057qib7 7310 30 was be VBD cord-005453-4057qib7 7310 31 constant constant JJ cord-005453-4057qib7 7310 32 over over IN cord-005453-4057qib7 7310 33 7 7 CD cord-005453-4057qib7 7310 34 g g NN cord-005453-4057qib7 7310 35 / / SYM cord-005453-4057qib7 7310 36 dl dl NN cord-005453-4057qib7 7310 37 . . . cord-005453-4057qib7 7311 1 Her -PRON- PRP$ cord-005453-4057qib7 7311 2 BM BM NNP cord-005453-4057qib7 7311 3 examination examination NN cord-005453-4057qib7 7311 4 showed show VBD cord-005453-4057qib7 7311 5 erythroid erythroid JJ cord-005453-4057qib7 7311 6 hyperplasia hyperplasia NN cord-005453-4057qib7 7311 7 and and CC cord-005453-4057qib7 7311 8 feature feature NN cord-005453-4057qib7 7311 9 of of IN cord-005453-4057qib7 7311 10 dyserythropoiesis dyserythropoiesis NN cord-005453-4057qib7 7311 11 with with IN cord-005453-4057qib7 7311 12 a a DT cord-005453-4057qib7 7311 13 few few JJ cord-005453-4057qib7 7311 14 binucleated binucleate VBN cord-005453-4057qib7 7311 15 erythroblasts erythroblast NNS cord-005453-4057qib7 7311 16 . . . cord-005453-4057qib7 7312 1 It -PRON- PRP cord-005453-4057qib7 7312 2 was be VBD cord-005453-4057qib7 7312 3 decided decide VBN cord-005453-4057qib7 7312 4 to to TO cord-005453-4057qib7 7312 5 follow follow VB cord-005453-4057qib7 7312 6 - - HYPH cord-005453-4057qib7 7312 7 up up NN cord-005453-4057qib7 7312 8 the the DT cord-005453-4057qib7 7312 9 patient patient NN cord-005453-4057qib7 7312 10 with with IN cord-005453-4057qib7 7312 11 a a DT cord-005453-4057qib7 7312 12 diagnosis diagnosis NN cord-005453-4057qib7 7312 13 of of IN cord-005453-4057qib7 7312 14 CDA CDA NNP cord-005453-4057qib7 7312 15 II II NNP cord-005453-4057qib7 7312 16 . . . cord-005453-4057qib7 7313 1 After after IN cord-005453-4057qib7 7313 2 the the DT cord-005453-4057qib7 7313 3 age age NN cord-005453-4057qib7 7313 4 of of IN cord-005453-4057qib7 7313 5 10-years 10-years CD cord-005453-4057qib7 7313 6 , , , cord-005453-4057qib7 7313 7 the the DT cord-005453-4057qib7 7313 8 need need NN cord-005453-4057qib7 7313 9 for for IN cord-005453-4057qib7 7313 10 transfusion transfusion NN cord-005453-4057qib7 7313 11 started start VBD cord-005453-4057qib7 7313 12 again again RB cord-005453-4057qib7 7313 13 for for IN cord-005453-4057qib7 7313 14 every every DT cord-005453-4057qib7 7313 15 4 4 CD cord-005453-4057qib7 7313 16 to to TO cord-005453-4057qib7 7313 17 5 5 CD cord-005453-4057qib7 7313 18 months month NNS cord-005453-4057qib7 7313 19 which which WDT cord-005453-4057qib7 7313 20 led lead VBD cord-005453-4057qib7 7313 21 the the DT cord-005453-4057qib7 7313 22 parents parent NNS cord-005453-4057qib7 7313 23 of of IN cord-005453-4057qib7 7313 24 our -PRON- PRP$ cord-005453-4057qib7 7313 25 patient patient NN cord-005453-4057qib7 7313 26 to to TO cord-005453-4057qib7 7313 27 request request VB cord-005453-4057qib7 7313 28 for for IN cord-005453-4057qib7 7313 29 bone bone NN cord-005453-4057qib7 7313 30 marrow marrow NN cord-005453-4057qib7 7313 31 transplantation transplantation NN cord-005453-4057qib7 7313 32 , , , cord-005453-4057qib7 7313 33 however however RB cord-005453-4057qib7 7313 34 , , , cord-005453-4057qib7 7313 35 the the DT cord-005453-4057qib7 7313 36 diagnosis diagnosis NN cord-005453-4057qib7 7313 37 was be VBD cord-005453-4057qib7 7313 38 not not RB cord-005453-4057qib7 7313 39 definite definite JJ cord-005453-4057qib7 7313 40 , , , cord-005453-4057qib7 7313 41 and and CC cord-005453-4057qib7 7313 42 because because IN cord-005453-4057qib7 7313 43 of of IN cord-005453-4057qib7 7313 44 the the DT cord-005453-4057qib7 7313 45 insufficient insufficient JJ cord-005453-4057qib7 7313 46 data datum NNS cord-005453-4057qib7 7313 47 for for IN cord-005453-4057qib7 7313 48 the the DT cord-005453-4057qib7 7313 49 transplantations transplantation NNS cord-005453-4057qib7 7313 50 for for IN cord-005453-4057qib7 7313 51 CDA CDA NNP cord-005453-4057qib7 7313 52 II II NNP cord-005453-4057qib7 7313 53 patients patient NNS cord-005453-4057qib7 7313 54 , , , cord-005453-4057qib7 7313 55 it -PRON- PRP cord-005453-4057qib7 7313 56 was be VBD cord-005453-4057qib7 7313 57 decided decide VBN cord-005453-4057qib7 7313 58 to to TO cord-005453-4057qib7 7313 59 go go VB cord-005453-4057qib7 7313 60 on on RP cord-005453-4057qib7 7313 61 to to TO cord-005453-4057qib7 7313 62 follow follow VB cord-005453-4057qib7 7313 63 - - HYPH cord-005453-4057qib7 7313 64 up up NN cord-005453-4057qib7 7313 65 . . . cord-005453-4057qib7 7314 1 Nevertheless nevertheless RB cord-005453-4057qib7 7314 2 , , , cord-005453-4057qib7 7314 3 after after IN cord-005453-4057qib7 7314 4 2 2 CD cord-005453-4057qib7 7314 5 years year NNS cord-005453-4057qib7 7314 6 , , , cord-005453-4057qib7 7314 7 the the DT cord-005453-4057qib7 7314 8 frequency frequency NN cord-005453-4057qib7 7314 9 of of IN cord-005453-4057qib7 7314 10 transfusion transfusion NN cord-005453-4057qib7 7314 11 gradually gradually RB cord-005453-4057qib7 7314 12 increased increase VBD cord-005453-4057qib7 7314 13 to to IN cord-005453-4057qib7 7314 14 every every DT cord-005453-4057qib7 7314 15 2 2 CD cord-005453-4057qib7 7314 16 - - SYM cord-005453-4057qib7 7314 17 3 3 CD cord-005453-4057qib7 7314 18 weeks week NNS cord-005453-4057qib7 7314 19 , , , cord-005453-4057qib7 7314 20 and and CC cord-005453-4057qib7 7314 21 bone bone NN cord-005453-4057qib7 7314 22 marrow marrow NN cord-005453-4057qib7 7314 23 transplantation transplantation NN cord-005453-4057qib7 7314 24 was be VBD cord-005453-4057qib7 7314 25 brought bring VBN cord-005453-4057qib7 7314 26 into into IN cord-005453-4057qib7 7314 27 question question NN cord-005453-4057qib7 7314 28 again again RB cord-005453-4057qib7 7314 29 . . . cord-005453-4057qib7 7315 1 At at IN cord-005453-4057qib7 7315 2 that that DT cord-005453-4057qib7 7315 3 time time NN cord-005453-4057qib7 7315 4 , , , cord-005453-4057qib7 7315 5 genetic genetic JJ cord-005453-4057qib7 7315 6 examination examination NN cord-005453-4057qib7 7315 7 was be VBD cord-005453-4057qib7 7315 8 started start VBN cord-005453-4057qib7 7315 9 and and CC cord-005453-4057qib7 7315 10 SEC23B sec23b NN cord-005453-4057qib7 7315 11 gene gene NN cord-005453-4057qib7 7315 12 was be VBD cord-005453-4057qib7 7315 13 analyzed analyze VBN cord-005453-4057qib7 7315 14 by by IN cord-005453-4057qib7 7315 15 direct direct JJ cord-005453-4057qib7 7315 16 sequencing sequencing NN cord-005453-4057qib7 7315 17 . . . cord-005453-4057qib7 7316 1 HSCT HSCT NNP cord-005453-4057qib7 7316 2 decision decision NN cord-005453-4057qib7 7316 3 from from IN cord-005453-4057qib7 7316 4 her -PRON- PRP$ cord-005453-4057qib7 7316 5 HLA HLA NNP cord-005453-4057qib7 7316 6 10/10 10/10 CD cord-005453-4057qib7 7316 7 matched match VBN cord-005453-4057qib7 7316 8 brother brother NN cord-005453-4057qib7 7316 9 , , , cord-005453-4057qib7 7316 10 carrying carry VBG cord-005453-4057qib7 7316 11 SEC23B SEC23B NNP cord-005453-4057qib7 7316 12 mutation mutation NN cord-005453-4057qib7 7316 13 in in IN cord-005453-4057qib7 7316 14 heterozygous heterozygous JJ cord-005453-4057qib7 7316 15 state state NN cord-005453-4057qib7 7316 16 , , , cord-005453-4057qib7 7316 17 was be VBD cord-005453-4057qib7 7316 18 taken take VBN cord-005453-4057qib7 7316 19 . . . cord-005453-4057qib7 7317 1 In in IN cord-005453-4057qib7 7317 2 the the DT cord-005453-4057qib7 7317 3 preparation preparation NN cord-005453-4057qib7 7317 4 regimen regimen NN cord-005453-4057qib7 7317 5 , , , cord-005453-4057qib7 7317 6 busulfan busulfan FW cord-005453-4057qib7 7317 7 ( ( -LRB- cord-005453-4057qib7 7317 8 Bu Bu NNP cord-005453-4057qib7 7317 9 ) ) -RRB- cord-005453-4057qib7 7317 10 at at IN cord-005453-4057qib7 7317 11 a a DT cord-005453-4057qib7 7317 12 myeloablative myeloablative JJ cord-005453-4057qib7 7317 13 weight weight NN cord-005453-4057qib7 7317 14 adjusted adjust VBN cord-005453-4057qib7 7317 15 dose dose NN cord-005453-4057qib7 7317 16 ( ( -LRB- cord-005453-4057qib7 7317 17 4 4 CD cord-005453-4057qib7 7317 18 days day NNS cord-005453-4057qib7 7317 19 ) ) -RRB- cord-005453-4057qib7 7317 20 , , , cord-005453-4057qib7 7317 21 200 200 CD cord-005453-4057qib7 7317 22 mg mg NNP cord-005453-4057qib7 7317 23 / / SYM cord-005453-4057qib7 7317 24 kg kg NNS cord-005453-4057qib7 7317 25 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 7317 26 ( ( -LRB- cord-005453-4057qib7 7317 27 Cy Cy NNP cord-005453-4057qib7 7317 28 ) ) -RRB- cord-005453-4057qib7 7317 29 ( ( -LRB- cord-005453-4057qib7 7317 30 4 4 CD cord-005453-4057qib7 7317 31 days day NNS cord-005453-4057qib7 7317 32 ) ) -RRB- cord-005453-4057qib7 7317 33 , , , cord-005453-4057qib7 7317 34 and and CC cord-005453-4057qib7 7317 35 30 30 CD cord-005453-4057qib7 7317 36 mg mg NNP cord-005453-4057qib7 7317 37 / / SYM cord-005453-4057qib7 7317 38 kg kg NNP cord-005453-4057qib7 7317 39 antithymocyte antithymocyte NNP cord-005453-4057qib7 7317 40 globulin globulin NNP cord-005453-4057qib7 7317 41 ( ( -LRB- cord-005453-4057qib7 7317 42 ATG ATG NNP cord-005453-4057qib7 7317 43 fresenius fresenius NNP cord-005453-4057qib7 7317 44 ) ) -RRB- cord-005453-4057qib7 7317 45 were be VBD cord-005453-4057qib7 7317 46 used use VBN cord-005453-4057qib7 7317 47 . . . cord-005453-4057qib7 7318 1 Graftversus Graftversus NNP cord-005453-4057qib7 7318 2 - - HYPH cord-005453-4057qib7 7318 3 host host NN cord-005453-4057qib7 7318 4 disease disease NN cord-005453-4057qib7 7318 5 ( ( -LRB- cord-005453-4057qib7 7318 6 GVHD GVHD NNP cord-005453-4057qib7 7318 7 ) ) -RRB- cord-005453-4057qib7 7318 8 prophylaxis prophylaxis NN cord-005453-4057qib7 7318 9 was be VBD cord-005453-4057qib7 7318 10 with with IN cord-005453-4057qib7 7318 11 cyclosporin cyclosporin NNP cord-005453-4057qib7 7318 12 A A NNP cord-005453-4057qib7 7318 13 started start VBD cord-005453-4057qib7 7318 14 on on IN cord-005453-4057qib7 7318 15 day day NN cord-005453-4057qib7 7318 16 -1 -1 NN cord-005453-4057qib7 7318 17 and and CC cord-005453-4057qib7 7318 18 short short JJ cord-005453-4057qib7 7318 19 - - HYPH cord-005453-4057qib7 7318 20 term term NN cord-005453-4057qib7 7318 21 methotrexate methotrexate NNP cord-005453-4057qib7 7318 22 on on IN cord-005453-4057qib7 7318 23 day day NN cord-005453-4057qib7 7319 1 +1,+3 +1,+3 NNP cord-005453-4057qib7 7319 2 and and CC cord-005453-4057qib7 7320 1 +6 +6 XX cord-005453-4057qib7 7320 2 . . . cord-005453-4057qib7 7321 1 She -PRON- PRP cord-005453-4057qib7 7321 2 was be VBD cord-005453-4057qib7 7321 3 transplanted transplant VBN cord-005453-4057qib7 7321 4 with with IN cord-005453-4057qib7 7321 5 BM BM NNP cord-005453-4057qib7 7321 6 with with IN cord-005453-4057qib7 7321 7 a a DT cord-005453-4057qib7 7321 8 dose dose NN cord-005453-4057qib7 7321 9 of of IN cord-005453-4057qib7 7321 10 total total JJ cord-005453-4057qib7 7321 11 nucleated nucleated JJ cord-005453-4057qib7 7321 12 cells=7.1x10 cells=7.1x10 NNP cord-005453-4057qib7 7321 13 8 8 CD cord-005453-4057qib7 7321 14 /kg /kg NFP cord-005453-4057qib7 7321 15 and and CC cord-005453-4057qib7 7321 16 CD34=3x10 CD34=3x10 NNP cord-005453-4057qib7 7321 17 6 6 CD cord-005453-4057qib7 7321 18 / / SYM cord-005453-4057qib7 7321 19 kg kg NNS cord-005453-4057qib7 7321 20 . . . cord-005453-4057qib7 7322 1 Neutrophile neutrophile JJ cord-005453-4057qib7 7322 2 and and CC cord-005453-4057qib7 7322 3 platelet platelet NN cord-005453-4057qib7 7322 4 engraftment engraftment NN cord-005453-4057qib7 7322 5 were be VBD cord-005453-4057qib7 7322 6 achieved achieve VBN cord-005453-4057qib7 7322 7 at at IN cord-005453-4057qib7 7322 8 +20 +20 CD cord-005453-4057qib7 7322 9 and and CC cord-005453-4057qib7 7322 10 +38 +38 NNS cord-005453-4057qib7 7322 11 , , , cord-005453-4057qib7 7322 12 respectively respectively RB cord-005453-4057qib7 7322 13 . . . cord-005453-4057qib7 7323 1 Indeed indeed RB cord-005453-4057qib7 7323 2 , , , cord-005453-4057qib7 7323 3 grade grade NN cord-005453-4057qib7 7323 4 4 4 CD cord-005453-4057qib7 7323 5 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 7323 6 cystitis cystitis NN cord-005453-4057qib7 7323 7 due due JJ cord-005453-4057qib7 7323 8 to to IN cord-005453-4057qib7 7323 9 BK BK NNP cord-005453-4057qib7 7323 10 virus virus NN cord-005453-4057qib7 7323 11 and and CC cord-005453-4057qib7 7323 12 a a DT cord-005453-4057qib7 7323 13 moderate moderate JJ cord-005453-4057qib7 7323 14 veno veno NNP cord-005453-4057qib7 7323 15 - - HYPH cord-005453-4057qib7 7323 16 occlusive occlusive JJ cord-005453-4057qib7 7323 17 disease disease NN cord-005453-4057qib7 7323 18 prolonged prolong VBD cord-005453-4057qib7 7323 19 platelet platelet NN cord-005453-4057qib7 7323 20 transfusion transfusion NN cord-005453-4057qib7 7323 21 days day NNS cord-005453-4057qib7 7323 22 which which WDT cord-005453-4057qib7 7323 23 concealed conceal VBD cord-005453-4057qib7 7323 24 the the DT cord-005453-4057qib7 7323 25 exact exact JJ cord-005453-4057qib7 7323 26 engraftment engraftment NNP cord-005453-4057qib7 7323 27 day day NN cord-005453-4057qib7 7323 28 of of IN cord-005453-4057qib7 7323 29 platelet platelet NN cord-005453-4057qib7 7323 30 . . . cord-005453-4057qib7 7324 1 The the DT cord-005453-4057qib7 7324 2 patient patient NN cord-005453-4057qib7 7324 3 was be VBD cord-005453-4057qib7 7324 4 discharged discharge VBN cord-005453-4057qib7 7324 5 on on IN cord-005453-4057qib7 7324 6 day day NN cord-005453-4057qib7 7324 7 45 45 CD cord-005453-4057qib7 7324 8 with with IN cord-005453-4057qib7 7324 9 no no DT cord-005453-4057qib7 7324 10 more more JJR cord-005453-4057qib7 7324 11 need need NN cord-005453-4057qib7 7324 12 for for IN cord-005453-4057qib7 7324 13 any any DT cord-005453-4057qib7 7324 14 transfusion transfusion NN cord-005453-4057qib7 7324 15 and and CC cord-005453-4057qib7 7324 16 followed follow VBD cord-005453-4057qib7 7324 17 up up RP cord-005453-4057qib7 7324 18 as as IN cord-005453-4057qib7 7324 19 a a DT cord-005453-4057qib7 7324 20 complete complete JJ cord-005453-4057qib7 7324 21 chimeric chimeric JJ cord-005453-4057qib7 7324 22 with with IN cord-005453-4057qib7 7324 23 no no DT cord-005453-4057qib7 7324 24 type type NN cord-005453-4057qib7 7324 25 of of IN cord-005453-4057qib7 7324 26 GVHD GVHD NNP cord-005453-4057qib7 7324 27 since since IN cord-005453-4057qib7 7324 28 then then RB cord-005453-4057qib7 7324 29 . . . cord-005453-4057qib7 7325 1 Now now RB cord-005453-4057qib7 7325 2 , , , cord-005453-4057qib7 7325 3 she -PRON- PRP cord-005453-4057qib7 7325 4 is be VBZ cord-005453-4057qib7 7325 5 20 20 CD cord-005453-4057qib7 7325 6 years year NNS cord-005453-4057qib7 7325 7 old old JJ cord-005453-4057qib7 7325 8 , , , cord-005453-4057qib7 7325 9 under under IN cord-005453-4057qib7 7325 10 regular regular JJ cord-005453-4057qib7 7325 11 surveillance surveillance NN cord-005453-4057qib7 7325 12 at at IN cord-005453-4057qib7 7325 13 our -PRON- PRP$ cord-005453-4057qib7 7325 14 transplant transplant NN cord-005453-4057qib7 7325 15 centre centre NN cord-005453-4057qib7 7325 16 without without IN cord-005453-4057qib7 7325 17 any any DT cord-005453-4057qib7 7325 18 symptoms symptom NNS cord-005453-4057qib7 7325 19 . . . cord-005453-4057qib7 7326 1 Conclusions conclusion NNS cord-005453-4057qib7 7326 2 : : : cord-005453-4057qib7 7326 3 HSCT HSCT NNP cord-005453-4057qib7 7326 4 data datum NNS cord-005453-4057qib7 7326 5 in in IN cord-005453-4057qib7 7326 6 CDA CDA NNP cord-005453-4057qib7 7326 7 II II NNP cord-005453-4057qib7 7326 8 patients patient NNS cord-005453-4057qib7 7326 9 is be VBZ cord-005453-4057qib7 7326 10 still still RB cord-005453-4057qib7 7326 11 insufficient insufficient JJ cord-005453-4057qib7 7326 12 , , , cord-005453-4057qib7 7326 13 however however RB cord-005453-4057qib7 7326 14 based base VBN cord-005453-4057qib7 7326 15 on on IN cord-005453-4057qib7 7326 16 data datum NNS cord-005453-4057qib7 7326 17 from from IN cord-005453-4057qib7 7326 18 TM TM NNP cord-005453-4057qib7 7326 19 patients patient NNS cord-005453-4057qib7 7326 20 with with IN cord-005453-4057qib7 7326 21 similar similar JJ cord-005453-4057qib7 7326 22 treatment treatment NN cord-005453-4057qib7 7326 23 approaches approach NNS cord-005453-4057qib7 7326 24 in in IN cord-005453-4057qib7 7326 25 TD TD NNP cord-005453-4057qib7 7326 26 CDA CDA NNP cord-005453-4057qib7 7326 27 II II NNP cord-005453-4057qib7 7326 28 patients patient NNS cord-005453-4057qib7 7327 1 , , , cord-005453-4057qib7 7327 2 it -PRON- PRP cord-005453-4057qib7 7327 3 is be VBZ cord-005453-4057qib7 7327 4 seen see VBN cord-005453-4057qib7 7327 5 that that IN cord-005453-4057qib7 7327 6 the the DT cord-005453-4057qib7 7327 7 HSCT HSCT NNP cord-005453-4057qib7 7327 8 is be VBZ cord-005453-4057qib7 7327 9 reliable reliable JJ cord-005453-4057qib7 7327 10 and and CC cord-005453-4057qib7 7327 11 effective effective JJ cord-005453-4057qib7 7327 12 . . . cord-005453-4057qib7 7328 1 Disclosure disclosure NN cord-005453-4057qib7 7328 2 : : : cord-005453-4057qib7 7328 3 Nothing nothing NN cord-005453-4057qib7 7328 4 to to TO cord-005453-4057qib7 7328 5 declare declare VB cord-005453-4057qib7 7328 6 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 7328 7 stem stem NN cord-005453-4057qib7 7328 8 cells cell NNS cord-005453-4057qib7 7329 1 Background background NN cord-005453-4057qib7 7329 2 : : : cord-005453-4057qib7 7330 1 The the DT cord-005453-4057qib7 7330 2 prognosis prognosis NN cord-005453-4057qib7 7330 3 after after IN cord-005453-4057qib7 7330 4 frontline frontline JJ cord-005453-4057qib7 7330 5 therapy therapy NN cord-005453-4057qib7 7330 6 in in IN cord-005453-4057qib7 7330 7 B B NNP cord-005453-4057qib7 7331 1 -ALL -ALL : cord-005453-4057qib7 7331 2 patients patient NNS cord-005453-4057qib7 7331 3 have have VBP cord-005453-4057qib7 7331 4 improved improve VBN cord-005453-4057qib7 7331 5 due due IN cord-005453-4057qib7 7331 6 to to IN cord-005453-4057qib7 7331 7 monoclonal monoclonal JJ cord-005453-4057qib7 7331 8 antibodies antibody NNS cord-005453-4057qib7 7331 9 ( ( -LRB- cord-005453-4057qib7 7331 10 CD20 CD20 NNP cord-005453-4057qib7 7331 11 , , , cord-005453-4057qib7 7331 12 CD19 CD19 NNP cord-005453-4057qib7 7331 13 , , , cord-005453-4057qib7 7331 14 CD22 CD22 NNP cord-005453-4057qib7 7331 15 ) ) -RRB- cord-005453-4057qib7 7331 16 and and CC cord-005453-4057qib7 7331 17 approximately approximately RB cord-005453-4057qib7 7331 18 90 90 CD cord-005453-4057qib7 7331 19 % % NN cord-005453-4057qib7 7331 20 of of IN cord-005453-4057qib7 7331 21 patients patient NNS cord-005453-4057qib7 7331 22 achieve achieve VB cord-005453-4057qib7 7331 23 complete complete JJ cord-005453-4057qib7 7331 24 remission remission NN cord-005453-4057qib7 7331 25 . . . cord-005453-4057qib7 7332 1 In in IN cord-005453-4057qib7 7332 2 relapsed relapsed JJ cord-005453-4057qib7 7332 3 and and CC cord-005453-4057qib7 7332 4 refractory refractory JJ cord-005453-4057qib7 7332 5 ( ( -LRB- cord-005453-4057qib7 7332 6 R/ R/ NNP cord-005453-4057qib7 7332 7 R r NN cord-005453-4057qib7 7332 8 ) ) -RRB- cord-005453-4057qib7 7332 9 B b NN cord-005453-4057qib7 7332 10 - - : cord-005453-4057qib7 7332 11 ALL all DT cord-005453-4057qib7 7332 12 and and CC cord-005453-4057qib7 7332 13 also also RB cord-005453-4057qib7 7332 14 in in IN cord-005453-4057qib7 7332 15 MRD MRD NNP cord-005453-4057qib7 7332 16 + + SYM cord-005453-4057qib7 7332 17 outcomes outcome NNS cord-005453-4057qib7 7332 18 are be VBP cord-005453-4057qib7 7332 19 relatively relatively RB cord-005453-4057qib7 7332 20 poor poor JJ cord-005453-4057qib7 7332 21 . . . cord-005453-4057qib7 7333 1 Disease disease NN cord-005453-4057qib7 7333 2 - - HYPH cord-005453-4057qib7 7333 3 free free JJ cord-005453-4057qib7 7333 4 survival survival NN cord-005453-4057qib7 7333 5 ( ( -LRB- cord-005453-4057qib7 7333 6 DFS DFS NNP cord-005453-4057qib7 7333 7 ) ) -RRB- cord-005453-4057qib7 7333 8 in in IN cord-005453-4057qib7 7333 9 this this DT cord-005453-4057qib7 7333 10 cohort cohort NN cord-005453-4057qib7 7333 11 is be VBZ cord-005453-4057qib7 7333 12 10 10 CD cord-005453-4057qib7 7333 13 - - SYM cord-005453-4057qib7 7333 14 20 20 CD cord-005453-4057qib7 7333 15 % % NN cord-005453-4057qib7 7333 16 . . . cord-005453-4057qib7 7334 1 In in IN cord-005453-4057qib7 7334 2 this this DT cord-005453-4057qib7 7334 3 cohort cohort NN cord-005453-4057qib7 7334 4 allo allo NN cord-005453-4057qib7 7334 5 - - HYPH cord-005453-4057qib7 7334 6 HSCT HSCT NNP cord-005453-4057qib7 7334 7 is be VBZ cord-005453-4057qib7 7334 8 indicated indicate VBN cord-005453-4057qib7 7334 9 and and CC cord-005453-4057qib7 7334 10 complete complete JJ cord-005453-4057qib7 7334 11 remission remission NN cord-005453-4057qib7 7334 12 before before IN cord-005453-4057qib7 7334 13 transplantation transplantation NN cord-005453-4057qib7 7334 14 is be VBZ cord-005453-4057qib7 7334 15 crucial crucial JJ cord-005453-4057qib7 7334 16 for for IN cord-005453-4057qib7 7334 17 prognosis prognosis NN cord-005453-4057qib7 7334 18 . . . cord-005453-4057qib7 7335 1 Conventional conventional JJ cord-005453-4057qib7 7335 2 chemotherapy chemotherapy NN cord-005453-4057qib7 7335 3 is be VBZ cord-005453-4057qib7 7335 4 associated associate VBN cord-005453-4057qib7 7335 5 with with IN cord-005453-4057qib7 7335 6 high high JJ cord-005453-4057qib7 7335 7 failure failure NN cord-005453-4057qib7 7335 8 rate rate NN cord-005453-4057qib7 7335 9 and and CC cord-005453-4057qib7 7335 10 significant significant JJ cord-005453-4057qib7 7335 11 toxicity toxicity NN cord-005453-4057qib7 7335 12 . . . cord-005453-4057qib7 7336 1 Immunotherapy immunotherapy NN cord-005453-4057qib7 7336 2 with with IN cord-005453-4057qib7 7336 3 monoclonal monoclonal JJ cord-005453-4057qib7 7336 4 antibodies antibody NNS cord-005453-4057qib7 7336 5 and and CC cord-005453-4057qib7 7336 6 CAR CAR NNP cord-005453-4057qib7 7336 7 - - HYPH cord-005453-4057qib7 7336 8 T T NNP cord-005453-4057qib7 7336 9 are be VBP cord-005453-4057qib7 7336 10 more more RBR cord-005453-4057qib7 7336 11 promising promising JJ cord-005453-4057qib7 7336 12 approaches approach NNS cord-005453-4057qib7 7336 13 . . . cord-005453-4057qib7 7337 1 The the DT cord-005453-4057qib7 7337 2 aim aim NN cord-005453-4057qib7 7337 3 was be VBD cord-005453-4057qib7 7337 4 to to TO cord-005453-4057qib7 7337 5 evaluate evaluate VB cord-005453-4057qib7 7337 6 the the DT cord-005453-4057qib7 7337 7 efficacy efficacy NN cord-005453-4057qib7 7337 8 ( ( -LRB- cord-005453-4057qib7 7337 9 frequency frequency NN cord-005453-4057qib7 7337 10 of of IN cord-005453-4057qib7 7337 11 responses response NNS cord-005453-4057qib7 7337 12 , , , cord-005453-4057qib7 7337 13 OS OS NNP cord-005453-4057qib7 7337 14 , , , cord-005453-4057qib7 7337 15 DFS DFS NNP cord-005453-4057qib7 7337 16 ) ) -RRB- cord-005453-4057qib7 7337 17 and and CC cord-005453-4057qib7 7337 18 toxicity toxicity NN cord-005453-4057qib7 7337 19 , , , cord-005453-4057qib7 7337 20 especially especially RB cord-005453-4057qib7 7337 21 neurotoxicity neurotoxicity NN cord-005453-4057qib7 7337 22 and and CC cord-005453-4057qib7 7337 23 cytokinerelease cytokinerelease NN cord-005453-4057qib7 7337 24 syndrome syndrome NN cord-005453-4057qib7 7337 25 , , , cord-005453-4057qib7 7337 26 of of IN cord-005453-4057qib7 7337 27 a a DT cord-005453-4057qib7 7337 28 bispecific bispecific NN cord-005453-4057qib7 7337 29 monoclonal monoclonal JJ cord-005453-4057qib7 7337 30 antibody antibody NN cord-005453-4057qib7 7337 31 blinatumomab blinatumomab NN cord-005453-4057qib7 7337 32 in in IN cord-005453-4057qib7 7337 33 patients patient NNS cord-005453-4057qib7 7337 34 both both CC cord-005453-4057qib7 7337 35 children child NNS cord-005453-4057qib7 7337 36 and and CC cord-005453-4057qib7 7337 37 adults adult NNS cord-005453-4057qib7 7337 38 with with IN cord-005453-4057qib7 7337 39 persistence persistence NN cord-005453-4057qib7 7337 40 of of IN cord-005453-4057qib7 7337 41 minimal minimal JJ cord-005453-4057qib7 7337 42 residual residual JJ cord-005453-4057qib7 7337 43 disease disease NN cord-005453-4057qib7 7337 44 ( ( -LRB- cord-005453-4057qib7 7337 45 MRD MRD NNP cord-005453-4057qib7 7337 46 + + SYM cord-005453-4057qib7 7337 47 ) ) -RRB- cord-005453-4057qib7 7337 48 or or CC cord-005453-4057qib7 7337 49 R r NN cord-005453-4057qib7 7337 50 / / SYM cord-005453-4057qib7 7337 51 R r NN cord-005453-4057qib7 7337 52 B b NN cord-005453-4057qib7 7337 53 - - , cord-005453-4057qib7 7337 54 ALL all DT cord-005453-4057qib7 7337 55 as as IN cord-005453-4057qib7 7337 56 a a DT cord-005453-4057qib7 7337 57 bridge bridge NN cord-005453-4057qib7 7337 58 to to IN cord-005453-4057qib7 7337 59 allo allo NN cord-005453-4057qib7 7337 60 - - HYPH cord-005453-4057qib7 7337 61 HSCT HSCT NNP cord-005453-4057qib7 7337 62 . . . cord-005453-4057qib7 7338 1 Methods method NNS cord-005453-4057qib7 7338 2 : : : cord-005453-4057qib7 7339 1 This this DT cord-005453-4057qib7 7339 2 study study NN cord-005453-4057qib7 7339 3 included include VBD cord-005453-4057qib7 7339 4 120 120 CD cord-005453-4057qib7 7339 5 patients patient NNS cord-005453-4057qib7 7339 6 with with IN cord-005453-4057qib7 7339 7 high high JJ cord-005453-4057qib7 7339 8 risk risk NN cord-005453-4057qib7 7339 9 B- b- NN cord-005453-4057qib7 7340 1 ALL all DT cord-005453-4057qib7 7340 2 blinatumomab blinatumomab NNS cord-005453-4057qib7 7340 3 treated treat VBN cord-005453-4057qib7 7340 4 in in IN cord-005453-4057qib7 7340 5 2013 2013 CD cord-005453-4057qib7 7340 6 - - SYM cord-005453-4057qib7 7340 7 2018 2018 CD cord-005453-4057qib7 7340 8 , , , cord-005453-4057qib7 7340 9 among among IN cord-005453-4057qib7 7340 10 them -PRON- PRP cord-005453-4057qib7 7340 11 14 14 CD cord-005453-4057qib7 7340 12 pts pt NNS cord-005453-4057qib7 7340 13 ( ( -LRB- cord-005453-4057qib7 7340 14 12 12 CD cord-005453-4057qib7 7340 15 % % NN cord-005453-4057qib7 7340 16 ) ) -RRB- cord-005453-4057qib7 7340 17 with with IN cord-005453-4057qib7 7340 18 t(9;22 t(9;22 NNP cord-005453-4057qib7 7340 19 ) ) -RRB- cord-005453-4057qib7 7340 20 , , , cord-005453-4057qib7 7340 21 10 10 CD cord-005453-4057qib7 7340 22 ( ( -LRB- cord-005453-4057qib7 7340 23 8 8 CD cord-005453-4057qib7 7340 24 % % NN cord-005453-4057qib7 7340 25 ) ) -RRB- cord-005453-4057qib7 7340 26 with with IN cord-005453-4057qib7 7340 27 t(4;11 t(4;11 NNP cord-005453-4057qib7 7340 28 ) ) -RRB- cord-005453-4057qib7 7340 29 , , , cord-005453-4057qib7 7340 30 with with IN cord-005453-4057qib7 7340 31 MLL MLL NNP cord-005453-4057qib7 7340 32 11(9 11(9 CD cord-005453-4057qib7 7340 33 % % NN cord-005453-4057qib7 7340 34 ) ) -RRB- cord-005453-4057qib7 7340 35 , , , cord-005453-4057qib7 7340 36 84 84 CD cord-005453-4057qib7 7340 37 pts pt NNS cord-005453-4057qib7 7340 38 ( ( -LRB- cord-005453-4057qib7 7340 39 70 70 CD cord-005453-4057qib7 7340 40 % % NN cord-005453-4057qib7 7340 41 ) ) -RRB- cord-005453-4057qib7 7340 42 who who WP cord-005453-4057qib7 7340 43 were be VBD cord-005453-4057qib7 7340 44 refractory refractory JJ cord-005453-4057qib7 7340 45 to to IN cord-005453-4057qib7 7340 46 previous previous JJ cord-005453-4057qib7 7340 47 chemotherapy chemotherapy NN cord-005453-4057qib7 7340 48 , , , cord-005453-4057qib7 7340 49 66 66 CD cord-005453-4057qib7 7340 50 ( ( -LRB- cord-005453-4057qib7 7340 51 30 30 CD cord-005453-4057qib7 7340 52 % % NN cord-005453-4057qib7 7340 53 ) ) -RRB- cord-005453-4057qib7 7340 54 after after IN cord-005453-4057qib7 7340 55 allo allo NN cord-005453-4057qib7 7340 56 - - HYPH cord-005453-4057qib7 7340 57 HSCT HSCT NNP cord-005453-4057qib7 7340 58 from from IN cord-005453-4057qib7 7340 59 deferent deferent JJ cord-005453-4057qib7 7340 60 type type NN cord-005453-4057qib7 7340 61 of of IN cord-005453-4057qib7 7340 62 donors donor NNS cord-005453-4057qib7 7340 63 . . . cord-005453-4057qib7 7341 1 Median median JJ cord-005453-4057qib7 7341 2 age age NN cord-005453-4057qib7 7341 3 was be VBD cord-005453-4057qib7 7341 4 21 21 CD cord-005453-4057qib7 7341 5 y.o y.o NNP cord-005453-4057qib7 7341 6 . . . cord-005453-4057qib7 7342 1 ( ( -LRB- cord-005453-4057qib7 7342 2 range range NNP cord-005453-4057qib7 7342 3 5m-71y.o 5m-71y.o CD cord-005453-4057qib7 7342 4 ) ) -RRB- cord-005453-4057qib7 7343 1 , , , cord-005453-4057qib7 7343 2 55 55 CD cord-005453-4057qib7 7343 3 children child NNS cord-005453-4057qib7 7343 4 0 0 CD cord-005453-4057qib7 7343 5 - - SYM cord-005453-4057qib7 7343 6 18 18 CD cord-005453-4057qib7 7343 7 y.o y.o NNP cord-005453-4057qib7 7343 8 . . NNP cord-005453-4057qib7 7343 9 ( ( -LRB- cord-005453-4057qib7 7343 10 46 46 CD cord-005453-4057qib7 7343 11 % % NN cord-005453-4057qib7 7343 12 ) ) -RRB- cord-005453-4057qib7 7343 13 and and CC cord-005453-4057qib7 7343 14 65 65 CD cord-005453-4057qib7 7343 15 adults adult NNS cord-005453-4057qib7 7343 16 > > NFP cord-005453-4057qib7 7343 17 18 18 CD cord-005453-4057qib7 7343 18 y.o y.o NNP cord-005453-4057qib7 7343 19 . . NNP cord-005453-4057qib7 7343 20 ( ( -LRB- cord-005453-4057qib7 7343 21 54 54 CD cord-005453-4057qib7 7343 22 % % NN cord-005453-4057qib7 7343 23 ) ) -RRB- cord-005453-4057qib7 7343 24 . . . cord-005453-4057qib7 7344 1 R r NN cord-005453-4057qib7 7344 2 / / SYM cord-005453-4057qib7 7344 3 R r NN cord-005453-4057qib7 7344 4 ALL all DT cord-005453-4057qib7 7344 5 had have VBD cord-005453-4057qib7 7344 6 63 63 CD cord-005453-4057qib7 7344 7 pts pt NNS cord-005453-4057qib7 7344 8 ( ( -LRB- cord-005453-4057qib7 7344 9 52 52 CD cord-005453-4057qib7 7344 10 % % NN cord-005453-4057qib7 7344 11 ) ) -RRB- cord-005453-4057qib7 7344 12 , , , cord-005453-4057qib7 7344 13 MRD MRD NNP cord-005453-4057qib7 7344 14 + + CC cord-005453-4057qib7 7344 15 -57 -57 NNP cord-005453-4057qib7 7344 16 pts pts NNP cord-005453-4057qib7 7344 17 ( ( -LRB- cord-005453-4057qib7 7344 18 48 48 CD cord-005453-4057qib7 7344 19 % % NN cord-005453-4057qib7 7344 20 ) ) -RRB- cord-005453-4057qib7 7344 21 , , , cord-005453-4057qib7 7344 22 median median JJ cord-005453-4057qib7 7344 23 days day NNS cord-005453-4057qib7 7344 24 of of IN cord-005453-4057qib7 7344 25 follow follow VBP cord-005453-4057qib7 7344 26 up up RP cord-005453-4057qib7 7344 27 were be VBD cord-005453-4057qib7 7344 28 227 227 CD cord-005453-4057qib7 7344 29 ( ( -LRB- cord-005453-4057qib7 7344 30 18 18 CD cord-005453-4057qib7 7344 31 - - SYM cord-005453-4057qib7 7344 32 720 720 CD cord-005453-4057qib7 7344 33 ) ) -RRB- cord-005453-4057qib7 7344 34 . . . cord-005453-4057qib7 7345 1 Blinatumomab Blinatumomab NNP cord-005453-4057qib7 7345 2 was be VBD cord-005453-4057qib7 7345 3 applied apply VBN cord-005453-4057qib7 7345 4 as as IN cord-005453-4057qib7 7345 5 28-day 28-day CD cord-005453-4057qib7 7345 6 cycles cycle NNS cord-005453-4057qib7 7345 7 followed follow VBN cord-005453-4057qib7 7345 8 by by IN cord-005453-4057qib7 7345 9 a a DT cord-005453-4057qib7 7345 10 14-day 14-day CD cord-005453-4057qib7 7345 11 off off NN cord-005453-4057qib7 7345 12 - - HYPH cord-005453-4057qib7 7345 13 period period NN cord-005453-4057qib7 7345 14 before before IN cord-005453-4057qib7 7345 15 the the DT cord-005453-4057qib7 7345 16 start start NN cord-005453-4057qib7 7345 17 of of IN cord-005453-4057qib7 7345 18 the the DT cord-005453-4057qib7 7345 19 following follow VBG cord-005453-4057qib7 7345 20 cycle cycle NN cord-005453-4057qib7 7345 21 . . . cord-005453-4057qib7 7346 1 Majority majority NN cord-005453-4057qib7 7346 2 pts pts CD cord-005453-4057qib7 7346 3 received receive VBD cord-005453-4057qib7 7346 4 one one CD cord-005453-4057qib7 7346 5 cycle cycle NN cord-005453-4057qib7 7346 6 ( ( -LRB- cord-005453-4057qib7 7346 7 N=94 N=94 NNP cord-005453-4057qib7 7346 8 , , , cord-005453-4057qib7 7346 9 78 78 CD cord-005453-4057qib7 7346 10 % % NN cord-005453-4057qib7 7346 11 ) ) -RRB- cord-005453-4057qib7 7346 12 . . . cord-005453-4057qib7 7347 1 In in IN cord-005453-4057qib7 7347 2 R r NN cord-005453-4057qib7 7347 3 / / SYM cord-005453-4057qib7 7347 4 R r NN cord-005453-4057qib7 7347 5 ALL all DT cord-005453-4057qib7 7347 6 group group NN cord-005453-4057qib7 7347 7 dose dose NN cord-005453-4057qib7 7347 8 was be VBD cord-005453-4057qib7 7347 9 of of IN cord-005453-4057qib7 7347 10 9 9 CD cord-005453-4057qib7 7347 11 mcg mcg NN cord-005453-4057qib7 7347 12 / / SYM cord-005453-4057qib7 7347 13 d d NN cord-005453-4057qib7 7347 14 during during IN cord-005453-4057qib7 7347 15 the the DT cord-005453-4057qib7 7347 16 first first JJ cord-005453-4057qib7 7347 17 7 7 CD cord-005453-4057qib7 7347 18 days day NNS cord-005453-4057qib7 7347 19 and and CC cord-005453-4057qib7 7347 20 afterwards afterwards RB cord-005453-4057qib7 7347 21 28mcg 28mcg CD cord-005453-4057qib7 7347 22 / / SYM cord-005453-4057qib7 7347 23 d d NN cord-005453-4057qib7 7347 24 . . . cord-005453-4057qib7 7348 1 Patients patient NNS cord-005453-4057qib7 7348 2 with with IN cord-005453-4057qib7 7348 3 weight weight NN cord-005453-4057qib7 7348 4 less less JJR cord-005453-4057qib7 7348 5 than than IN cord-005453-4057qib7 7348 6 45 45 CD cord-005453-4057qib7 7348 7 kg kg NNS cord-005453-4057qib7 7348 8 received receive VBD cord-005453-4057qib7 7348 9 5 5 CD cord-005453-4057qib7 7348 10 mcg mcg NNP cord-005453-4057qib7 7348 11 / / SYM cord-005453-4057qib7 7348 12 m m NN cord-005453-4057qib7 7348 13 2 2 CD cord-005453-4057qib7 7348 14 /d /d NNP cord-005453-4057qib7 7348 15 and and CC cord-005453-4057qib7 7348 16 15mkg 15mkg NNP cord-005453-4057qib7 7348 17 / / SYM cord-005453-4057qib7 7348 18 m m NN cord-005453-4057qib7 7349 1 2 2 LS cord-005453-4057qib7 7349 2 /d /d NNP cord-005453-4057qib7 7349 3 accordingly accordingly RB cord-005453-4057qib7 7349 4 . . . cord-005453-4057qib7 7350 1 In in IN cord-005453-4057qib7 7350 2 MRD MRD NNP cord-005453-4057qib7 7350 3 group group NN cord-005453-4057qib7 7350 4 dose dose NN cord-005453-4057qib7 7350 5 was be VBD cord-005453-4057qib7 7350 6 15 15 CD cord-005453-4057qib7 7350 7 mcg mcg NN cord-005453-4057qib7 7350 8 / / SYM cord-005453-4057qib7 7350 9 m m NN cord-005453-4057qib7 7350 10 2 2 CD cord-005453-4057qib7 7351 1 /d /d NNP cord-005453-4057qib7 7351 2 . . . cord-005453-4057qib7 7352 1 Results result NNS cord-005453-4057qib7 7352 2 : : : cord-005453-4057qib7 7353 1 The the DT cord-005453-4057qib7 7353 2 frequency frequency NN cord-005453-4057qib7 7353 3 of of IN cord-005453-4057qib7 7353 4 responses response NNS cord-005453-4057qib7 7353 5 to to IN cord-005453-4057qib7 7353 6 blinatumomab blinatumomab NNP cord-005453-4057qib7 7353 7 was be VBD cord-005453-4057qib7 7353 8 higher high JJR cord-005453-4057qib7 7353 9 in in IN cord-005453-4057qib7 7353 10 MRD MRD NNP cord-005453-4057qib7 7353 11 + + CC cord-005453-4057qib7 7353 12 pts pt NNS cord-005453-4057qib7 7353 13 in in IN cord-005453-4057qib7 7353 14 comparison comparison NN cord-005453-4057qib7 7353 15 R r NN cord-005453-4057qib7 7353 16 / / SYM cord-005453-4057qib7 7353 17 R r NN cord-005453-4057qib7 7354 1 ALL all DT cord-005453-4057qib7 7354 2 pts pt NNS cord-005453-4057qib7 7354 3 ( ( -LRB- cord-005453-4057qib7 7354 4 85 85 CD cord-005453-4057qib7 7354 5 % % NN cord-005453-4057qib7 7354 6 vs vs IN cord-005453-4057qib7 7354 7 62 62 CD cord-005453-4057qib7 7354 8 % % NN cord-005453-4057qib7 7354 9 p=0.007 p=0.007 NN cord-005453-4057qib7 7354 10 ) ) -RRB- cord-005453-4057qib7 7354 11 . . . cord-005453-4057qib7 7355 1 In in IN cord-005453-4057qib7 7355 2 MRD MRD NNP cord-005453-4057qib7 7355 3 + + CC cord-005453-4057qib7 7355 4 pts pts NN cord-005453-4057qib7 7355 5 CR CR NNP cord-005453-4057qib7 7355 6 MRDwas MRDwas NNP cord-005453-4057qib7 7355 7 achieved achieve VBN cord-005453-4057qib7 7355 8 in in IN cord-005453-4057qib7 7355 9 47 47 CD cord-005453-4057qib7 7355 10 pts pt NNS cord-005453-4057qib7 7355 11 ( ( -LRB- cord-005453-4057qib7 7355 12 82.5 82.5 CD cord-005453-4057qib7 7355 13 % % NN cord-005453-4057qib7 7355 14 ) ) -RRB- cord-005453-4057qib7 7355 15 , , , cord-005453-4057qib7 7355 16 10 10 CD cord-005453-4057qib7 7355 17 pts pt NNS cord-005453-4057qib7 7355 18 ( ( -LRB- cord-005453-4057qib7 7355 19 17.5 17.5 CD cord-005453-4057qib7 7355 20 % % NN cord-005453-4057qib7 7355 21 ) ) -RRB- cord-005453-4057qib7 7355 22 were be VBD cord-005453-4057qib7 7355 23 MRD+ MRD+ NNP cord-005453-4057qib7 7355 24 after after IN cord-005453-4057qib7 7355 25 blinatumomab blinatumomab NNS cord-005453-4057qib7 7355 26 . . . cord-005453-4057qib7 7356 1 Two two CD cord-005453-4057qib7 7356 2 - - HYPH cord-005453-4057qib7 7356 3 year year NN cord-005453-4057qib7 7356 4 OS os NN cord-005453-4057qib7 7356 5 in in IN cord-005453-4057qib7 7356 6 this this DT cord-005453-4057qib7 7356 7 group group NN cord-005453-4057qib7 7356 8 was be VBD cord-005453-4057qib7 7356 9 61 61 CD cord-005453-4057qib7 7356 10 % % NN cord-005453-4057qib7 7356 11 . . . cord-005453-4057qib7 7357 1 Twenty twenty CD cord-005453-4057qib7 7357 2 pts pts NN cord-005453-4057qib7 7357 3 ( ( -LRB- cord-005453-4057qib7 7357 4 34 34 CD cord-005453-4057qib7 7357 5 % % NN cord-005453-4057qib7 7357 6 ) ) -RRB- cord-005453-4057qib7 7357 7 received receive VBD cord-005453-4057qib7 7357 8 allo allo NN cord-005453-4057qib7 7357 9 - - HYPH cord-005453-4057qib7 7357 10 HSCT HSCT NNP cord-005453-4057qib7 7357 11 . . . cord-005453-4057qib7 7358 1 In in IN cord-005453-4057qib7 7358 2 RR RR NNP cord-005453-4057qib7 7358 3 ALL all DT cord-005453-4057qib7 7358 4 pts pts NN cord-005453-4057qib7 7358 5 CR CR NNP cord-005453-4057qib7 7358 6 MRDwas MRDwas NNP cord-005453-4057qib7 7358 7 achieved achieve VBN cord-005453-4057qib7 7358 8 in in IN cord-005453-4057qib7 7358 9 30 30 CD cord-005453-4057qib7 7358 10 pts pt NNS cord-005453-4057qib7 7358 11 ( ( -LRB- cord-005453-4057qib7 7358 12 48 48 CD cord-005453-4057qib7 7358 13 % % NN cord-005453-4057qib7 7358 14 ) ) -RRB- cord-005453-4057qib7 7358 15 , , , cord-005453-4057qib7 7358 16 9 9 CD cord-005453-4057qib7 7358 17 pts pt NNS cord-005453-4057qib7 7358 18 ( ( -LRB- cord-005453-4057qib7 7358 19 14 14 CD cord-005453-4057qib7 7358 20 % % NN cord-005453-4057qib7 7358 21 ) ) -RRB- cord-005453-4057qib7 7358 22 were be VBD cord-005453-4057qib7 7358 23 MRD+ MRD+ NNP cord-005453-4057qib7 7358 24 after after IN cord-005453-4057qib7 7358 25 blinatumomab blinatumomab NNS cord-005453-4057qib7 7358 26 , , , cord-005453-4057qib7 7358 27 24 24 CD cord-005453-4057qib7 7358 28 pts pt NNS cord-005453-4057qib7 7358 29 ( ( -LRB- cord-005453-4057qib7 7358 30 38 38 CD cord-005453-4057qib7 7358 31 % % NN cord-005453-4057qib7 7358 32 ) ) -RRB- cord-005453-4057qib7 7358 33 had have VBD cord-005453-4057qib7 7358 34 no no DT cord-005453-4057qib7 7358 35 hematological hematological JJ cord-005453-4057qib7 7358 36 response response NN cord-005453-4057qib7 7358 37 . . . cord-005453-4057qib7 7359 1 Two two CD cord-005453-4057qib7 7359 2 - - HYPH cord-005453-4057qib7 7359 3 year year NN cord-005453-4057qib7 7359 4 OS os NN cord-005453-4057qib7 7359 5 in in IN cord-005453-4057qib7 7359 6 R r NN cord-005453-4057qib7 7359 7 / / SYM cord-005453-4057qib7 7359 8 R r NN cord-005453-4057qib7 7359 9 ALL all DT cord-005453-4057qib7 7359 10 was be VBD cord-005453-4057qib7 7359 11 43 43 CD cord-005453-4057qib7 7359 12 % % NN cord-005453-4057qib7 7359 13 . . . cord-005453-4057qib7 7360 1 Fifteen fifteen CD cord-005453-4057qib7 7360 2 pts pts NN cord-005453-4057qib7 7360 3 ( ( -LRB- cord-005453-4057qib7 7360 4 24 24 CD cord-005453-4057qib7 7360 5 % % NN cord-005453-4057qib7 7360 6 ) ) -RRB- cord-005453-4057qib7 7360 7 received receive VBD cord-005453-4057qib7 7360 8 allo allo NN cord-005453-4057qib7 7360 9 - - HYPH cord-005453-4057qib7 7360 10 HSCT HSCT NNP cord-005453-4057qib7 7360 11 . . . cord-005453-4057qib7 7361 1 OS OS NNP cord-005453-4057qib7 7361 2 in in IN cord-005453-4057qib7 7361 3 CR CR NNP cord-005453-4057qib7 7361 4 MRDpatients mrdpatient NNS cord-005453-4057qib7 7361 5 who who WP cord-005453-4057qib7 7361 6 received receive VBD cord-005453-4057qib7 7361 7 allo allo NN cord-005453-4057qib7 7361 8 - - HYPH cord-005453-4057qib7 7361 9 HSCT HSCT NNP cord-005453-4057qib7 7361 10 was be VBD cord-005453-4057qib7 7361 11 not not RB cord-005453-4057qib7 7361 12 significantly significantly RB cord-005453-4057qib7 7361 13 different different JJ cord-005453-4057qib7 7361 14 in in IN cord-005453-4057qib7 7361 15 comparison comparison NN cord-005453-4057qib7 7361 16 with with IN cord-005453-4057qib7 7361 17 patients patient NNS cord-005453-4057qib7 7361 18 who who WP cord-005453-4057qib7 7361 19 received receive VBD cord-005453-4057qib7 7361 20 blinatumomab blinatumomab NNS cord-005453-4057qib7 7361 21 as as IN cord-005453-4057qib7 7361 22 a a DT cord-005453-4057qib7 7361 23 monotherapy monotherapy NN cord-005453-4057qib7 7361 24 ( ( -LRB- cord-005453-4057qib7 7361 25 84 84 CD cord-005453-4057qib7 7361 26 % % NN cord-005453-4057qib7 7361 27 vs vs IN cord-005453-4057qib7 7361 28 71 71 CD cord-005453-4057qib7 7361 29 % % NN cord-005453-4057qib7 7361 30 , , , cord-005453-4057qib7 7361 31 p=0.08 p=0.08 NNP cord-005453-4057qib7 7361 32 ) ) -RRB- cord-005453-4057qib7 7361 33 . . . cord-005453-4057qib7 7362 1 No no DT cord-005453-4057qib7 7362 2 significant significant JJ cord-005453-4057qib7 7362 3 differences difference NNS cord-005453-4057qib7 7362 4 in in IN cord-005453-4057qib7 7362 5 DFS DFS NNP cord-005453-4057qib7 7362 6 were be VBD cord-005453-4057qib7 7362 7 observed observe VBN cord-005453-4057qib7 7362 8 at at IN cord-005453-4057qib7 7362 9 two two CD cord-005453-4057qib7 7362 10 years year NNS cord-005453-4057qib7 7362 11 in in IN cord-005453-4057qib7 7362 12 CR cr NN cord-005453-4057qib7 7362 13 MRDpts MRDpts NNP cord-005453-4057qib7 7362 14 depending depend VBG cord-005453-4057qib7 7362 15 status status NN cord-005453-4057qib7 7362 16 of of IN cord-005453-4057qib7 7362 17 the the DT cord-005453-4057qib7 7362 18 disease disease NN cord-005453-4057qib7 7362 19 before before IN cord-005453-4057qib7 7362 20 therapy therapy NN cord-005453-4057qib7 7362 21 - - HYPH cord-005453-4057qib7 7362 22 MRD MRD NNP cord-005453-4057qib7 7362 23 vs vs IN cord-005453-4057qib7 7362 24 R R NNP cord-005453-4057qib7 7362 25 / / SYM cord-005453-4057qib7 7362 26 R r NN cord-005453-4057qib7 7362 27 ( ( -LRB- cord-005453-4057qib7 7362 28 66 66 CD cord-005453-4057qib7 7362 29 % % NN cord-005453-4057qib7 7362 30 vs vs IN cord-005453-4057qib7 7362 31 59 59 CD cord-005453-4057qib7 7362 32 % % NN cord-005453-4057qib7 7362 33 ) ) -RRB- cord-005453-4057qib7 7362 34 . . . cord-005453-4057qib7 7363 1 Of of IN cord-005453-4057qib7 7363 2 the the DT cord-005453-4057qib7 7363 3 reported report VBN cord-005453-4057qib7 7363 4 adverse adverse JJ cord-005453-4057qib7 7363 5 events event NNS cord-005453-4057qib7 7363 6 , , , cord-005453-4057qib7 7363 7 febrile febrile JJ cord-005453-4057qib7 7363 8 fever fever NN cord-005453-4057qib7 7363 9 was be VBD cord-005453-4057qib7 7363 10 the the DT cord-005453-4057qib7 7363 11 most most RBS cord-005453-4057qib7 7363 12 common common JJ cord-005453-4057qib7 7363 13 91pts 91pts XX cord-005453-4057qib7 7363 14 ( ( -LRB- cord-005453-4057qib7 7363 15 76 76 CD cord-005453-4057qib7 7363 16 % % NN cord-005453-4057qib7 7363 17 ) ) -RRB- cord-005453-4057qib7 7363 18 , , , cord-005453-4057qib7 7363 19 neutropenia neutropenia NN cord-005453-4057qib7 7363 20 43 43 CD cord-005453-4057qib7 7363 21 ( ( -LRB- cord-005453-4057qib7 7363 22 35 35 CD cord-005453-4057qib7 7363 23 % % NN cord-005453-4057qib7 7363 24 ) ) -RRB- cord-005453-4057qib7 7363 25 , , , cord-005453-4057qib7 7363 26 thrombocytopenia thrombocytopenia VBD cord-005453-4057qib7 7363 27 46 46 CD cord-005453-4057qib7 7363 28 ( ( -LRB- cord-005453-4057qib7 7363 29 38 38 CD cord-005453-4057qib7 7363 30 % % NN cord-005453-4057qib7 7363 31 ) ) -RRB- cord-005453-4057qib7 7363 32 , , , cord-005453-4057qib7 7363 33 infection infection NN cord-005453-4057qib7 7363 34 32 32 CD cord-005453-4057qib7 7363 35 ( ( -LRB- cord-005453-4057qib7 7363 36 26 26 CD cord-005453-4057qib7 7363 37 % % NN cord-005453-4057qib7 7363 38 ) ) -RRB- cord-005453-4057qib7 7363 39 , , , cord-005453-4057qib7 7363 40 neurotoxicity neurotoxicity NN cord-005453-4057qib7 7363 41 29 29 CD cord-005453-4057qib7 7363 42 ( ( -LRB- cord-005453-4057qib7 7363 43 24 24 CD cord-005453-4057qib7 7363 44 % % NN cord-005453-4057qib7 7363 45 ) ) -RRB- cord-005453-4057qib7 7363 46 , , , cord-005453-4057qib7 7363 47 cytokine cytokine NN cord-005453-4057qib7 7363 48 - - HYPH cord-005453-4057qib7 7363 49 release release NN cord-005453-4057qib7 7363 50 syndrome syndrome NN cord-005453-4057qib7 7363 51 8 8 CD cord-005453-4057qib7 7363 52 ( ( -LRB- cord-005453-4057qib7 7363 53 7 7 CD cord-005453-4057qib7 7363 54 % % NN cord-005453-4057qib7 7363 55 ) ) -RRB- cord-005453-4057qib7 7363 56 . . . cord-005453-4057qib7 7364 1 All all DT cord-005453-4057qib7 7364 2 complications complication NNS cord-005453-4057qib7 7364 3 were be VBD cord-005453-4057qib7 7364 4 reversible reversible JJ cord-005453-4057qib7 7364 5 . . . cord-005453-4057qib7 7365 1 Conclusions conclusion NNS cord-005453-4057qib7 7365 2 : : : cord-005453-4057qib7 7366 1 Blinatumomab Blinatumomab NNP cord-005453-4057qib7 7366 2 is be VBZ cord-005453-4057qib7 7366 3 effective effective JJ cord-005453-4057qib7 7366 4 option option NN cord-005453-4057qib7 7366 5 in in IN cord-005453-4057qib7 7366 6 patients patient NNS cord-005453-4057qib7 7366 7 with with IN cord-005453-4057qib7 7366 8 high high JJ cord-005453-4057qib7 7366 9 risk risk NN cord-005453-4057qib7 7366 10 B b NN cord-005453-4057qib7 7366 11 - - : cord-005453-4057qib7 7366 12 ALL all DT cord-005453-4057qib7 7366 13 especially especially RB cord-005453-4057qib7 7366 14 in in IN cord-005453-4057qib7 7366 15 the the DT cord-005453-4057qib7 7366 16 group group NN cord-005453-4057qib7 7366 17 with with IN cord-005453-4057qib7 7366 18 MRD MRD NNP cord-005453-4057qib7 7366 19 persistence persistence NN cord-005453-4057qib7 7366 20 after after IN cord-005453-4057qib7 7366 21 previous previous JJ cord-005453-4057qib7 7366 22 chemotherapy chemotherapy NN cord-005453-4057qib7 7366 23 and and CC cord-005453-4057qib7 7366 24 facilitates facilitate VBZ cord-005453-4057qib7 7366 25 effective effective JJ cord-005453-4057qib7 7366 26 bridging bridging NN cord-005453-4057qib7 7366 27 to to IN cord-005453-4057qib7 7366 28 HSCT HSCT NNP cord-005453-4057qib7 7366 29 . . . cord-005453-4057qib7 7367 1 Blinatumomab blinatumomab JJ cord-005453-4057qib7 7367 2 therapy therapy NN cord-005453-4057qib7 7367 3 is be VBZ cord-005453-4057qib7 7367 4 generally generally RB cord-005453-4057qib7 7367 5 well well RB cord-005453-4057qib7 7367 6 tolerated tolerate VBN cord-005453-4057qib7 7367 7 . . . cord-005453-4057qib7 7368 1 Disclosure disclosure NN cord-005453-4057qib7 7368 2 Here here RB cord-005453-4057qib7 7369 1 we -PRON- PRP cord-005453-4057qib7 7369 2 address address VBP cord-005453-4057qib7 7369 3 the the DT cord-005453-4057qib7 7369 4 transcriptional transcriptional JJ cord-005453-4057qib7 7369 5 regulation regulation NN cord-005453-4057qib7 7369 6 of of IN cord-005453-4057qib7 7369 7 differentiated differentiated JJ cord-005453-4057qib7 7369 8 cells cell NNS cord-005453-4057qib7 7369 9 from from IN cord-005453-4057qib7 7369 10 human human JJ cord-005453-4057qib7 7369 11 embryonic embryonic JJ cord-005453-4057qib7 7369 12 stem stem NN cord-005453-4057qib7 7369 13 cells cell NNS cord-005453-4057qib7 7369 14 ( ( -LRB- cord-005453-4057qib7 7369 15 ESCs esc NNS cord-005453-4057qib7 7369 16 ) ) -RRB- cord-005453-4057qib7 7369 17 using use VBG cord-005453-4057qib7 7369 18 self self NN cord-005453-4057qib7 7369 19 - - HYPH cord-005453-4057qib7 7369 20 assembling assemble VBG cord-005453-4057qib7 7369 21 peptide peptide JJ cord-005453-4057qib7 7369 22 hydrogel hydrogel NN cord-005453-4057qib7 7369 23 without without IN cord-005453-4057qib7 7369 24 stromal stromal JJ cord-005453-4057qib7 7369 25 cells cell NNS cord-005453-4057qib7 7369 26 , , , cord-005453-4057qib7 7369 27 and and CC cord-005453-4057qib7 7369 28 compare compare VBP cord-005453-4057qib7 7369 29 with with IN cord-005453-4057qib7 7369 30 embryoid embryoid JJ cord-005453-4057qib7 7369 31 body body NN cord-005453-4057qib7 7369 32 ( ( -LRB- cord-005453-4057qib7 7369 33 EB EB NNP cord-005453-4057qib7 7369 34 ) ) -RRB- cord-005453-4057qib7 7369 35 culture culture NN cord-005453-4057qib7 7369 36 system system NN cord-005453-4057qib7 7369 37 . . . cord-005453-4057qib7 7370 1 Methods method NNS cord-005453-4057qib7 7370 2 : : : cord-005453-4057qib7 7370 3 ESC esc NN cord-005453-4057qib7 7370 4 differentiation differentiation NN cord-005453-4057qib7 7370 5 was be VBD cord-005453-4057qib7 7370 6 induced induce VBN cord-005453-4057qib7 7370 7 in in IN cord-005453-4057qib7 7370 8 EB EB NNP cord-005453-4057qib7 7370 9 culture culture NN cord-005453-4057qib7 7370 10 system system NN cord-005453-4057qib7 7370 11 or or CC cord-005453-4057qib7 7370 12 three three CD cord-005453-4057qib7 7370 13 - - HYPH cord-005453-4057qib7 7370 14 dimensional dimensional JJ cord-005453-4057qib7 7370 15 ( ( -LRB- cord-005453-4057qib7 7370 16 3D 3D NNP cord-005453-4057qib7 7370 17 ) ) -RRB- cord-005453-4057qib7 7370 18 hydrogel hydrogel NN cord-005453-4057qib7 7370 19 culture culture NN cord-005453-4057qib7 7370 20 system system NN cord-005453-4057qib7 7370 21 . . . cord-005453-4057qib7 7371 1 The the DT cord-005453-4057qib7 7371 2 engraftment engraftment NN cord-005453-4057qib7 7371 3 potential potential NN cord-005453-4057qib7 7371 4 of of IN cord-005453-4057qib7 7371 5 differentiated differentiated JJ cord-005453-4057qib7 7371 6 cells cell NNS cord-005453-4057qib7 7371 7 was be VBD cord-005453-4057qib7 7371 8 evaluated evaluate VBN cord-005453-4057qib7 7371 9 by by IN cord-005453-4057qib7 7371 10 flow flow NN cord-005453-4057qib7 7371 11 cytometry cytometry NN cord-005453-4057qib7 7371 12 . . . cord-005453-4057qib7 7372 1 CD34 CD34 NNP cord-005453-4057qib7 7372 2 + + CC cord-005453-4057qib7 7372 3 cells cell NNS cord-005453-4057qib7 7372 4 from from IN cord-005453-4057qib7 7372 5 mobilized mobilize VBN cord-005453-4057qib7 7372 6 peripheral peripheral JJ cord-005453-4057qib7 7372 7 mononuclear mononuclear JJ cord-005453-4057qib7 7372 8 blood blood NN cord-005453-4057qib7 7372 9 cells cell NNS cord-005453-4057qib7 7372 10 ( ( -LRB- cord-005453-4057qib7 7372 11 mPBMCs mpbmcs CD cord-005453-4057qib7 7372 12 ) ) -RRB- cord-005453-4057qib7 7372 13 or or CC cord-005453-4057qib7 7372 14 differentiated differentiate VBN cord-005453-4057qib7 7372 15 from from IN cord-005453-4057qib7 7372 16 ESCs esc NNS cord-005453-4057qib7 7372 17 at at IN cord-005453-4057qib7 7372 18 different different JJ cord-005453-4057qib7 7372 19 times time NNS cord-005453-4057qib7 7372 20 ( ( -LRB- cord-005453-4057qib7 7372 21 day day NN cord-005453-4057qib7 7372 22 7 7 CD cord-005453-4057qib7 7372 23 , , , cord-005453-4057qib7 7372 24 day day NN cord-005453-4057qib7 7372 25 10 10 CD cord-005453-4057qib7 7372 26 , , , cord-005453-4057qib7 7372 27 day day NN cord-005453-4057qib7 7372 28 14 14 CD cord-005453-4057qib7 7372 29 ) ) -RRB- cord-005453-4057qib7 7372 30 were be VBD cord-005453-4057qib7 7372 31 purified purify VBN cord-005453-4057qib7 7372 32 by by IN cord-005453-4057qib7 7372 33 fluorescent fluorescent NN cord-005453-4057qib7 7372 34 - - HYPH cord-005453-4057qib7 7372 35 activated activate VBN cord-005453-4057qib7 7372 36 cell cell NN cord-005453-4057qib7 7372 37 sorting sorting NN cord-005453-4057qib7 7372 38 . . . cord-005453-4057qib7 7373 1 Sorted sorted JJ cord-005453-4057qib7 7373 2 cells cell NNS cord-005453-4057qib7 7373 3 were be VBD cord-005453-4057qib7 7373 4 captured capture VBN cord-005453-4057qib7 7373 5 on on IN cord-005453-4057qib7 7373 6 medium medium JJ cord-005453-4057qib7 7373 7 - - HYPH cord-005453-4057qib7 7373 8 sized sized JJ cord-005453-4057qib7 7373 9 microfluidic microfluidic JJ cord-005453-4057qib7 7373 10 chips chip NNS cord-005453-4057qib7 7373 11 using use VBG cord-005453-4057qib7 7373 12 the the DT cord-005453-4057qib7 7373 13 Fluidigm Fluidigm NNP cord-005453-4057qib7 7373 14 C1 C1 NNP cord-005453-4057qib7 7373 15 Single Single NNP cord-005453-4057qib7 7373 16 Cell Cell NNP cord-005453-4057qib7 7373 17 Auto Auto NNP cord-005453-4057qib7 7373 18 Prep Prep NNP cord-005453-4057qib7 7373 19 System System NNP cord-005453-4057qib7 7373 20 . . . cord-005453-4057qib7 7374 1 Sequencing sequencing NN cord-005453-4057qib7 7374 2 was be VBD cord-005453-4057qib7 7374 3 performed perform VBN cord-005453-4057qib7 7374 4 by by IN cord-005453-4057qib7 7374 5 HiSeq HiSeq NNP cord-005453-4057qib7 7374 6 X X NNP cord-005453-4057qib7 7374 7 Ten Ten NNP cord-005453-4057qib7 7374 8 . . . cord-005453-4057qib7 7375 1 Results result NNS cord-005453-4057qib7 7375 2 : : : cord-005453-4057qib7 7376 1 Self self NN cord-005453-4057qib7 7376 2 - - HYPH cord-005453-4057qib7 7376 3 assembling assemble VBG cord-005453-4057qib7 7376 4 peptide peptide JJ cord-005453-4057qib7 7376 5 hydrogel hydrogel NN cord-005453-4057qib7 7376 6 formed form VBD cord-005453-4057qib7 7376 7 a a DT cord-005453-4057qib7 7376 8 3D 3d JJ cord-005453-4057qib7 7376 9 scaffold scaffold NN cord-005453-4057qib7 7376 10 for for IN cord-005453-4057qib7 7376 11 cell cell NN cord-005453-4057qib7 7376 12 culture culture NN cord-005453-4057qib7 7376 13 , , , cord-005453-4057qib7 7376 14 the the DT cord-005453-4057qib7 7376 15 pore pore NN cord-005453-4057qib7 7376 16 diameter diameter NN cord-005453-4057qib7 7376 17 of of IN cord-005453-4057qib7 7376 18 which which WDT cord-005453-4057qib7 7376 19 ranged range VBD cord-005453-4057qib7 7376 20 from from IN cord-005453-4057qib7 7376 21 50 50 CD cord-005453-4057qib7 7376 22 to to IN cord-005453-4057qib7 7376 23 200 200 CD cord-005453-4057qib7 7376 24 nm nm NN cord-005453-4057qib7 7376 25 . . . cord-005453-4057qib7 7377 1 Compared compare VBN cord-005453-4057qib7 7377 2 to to IN cord-005453-4057qib7 7377 3 EB eb NN cord-005453-4057qib7 7377 4 culture culture NN cord-005453-4057qib7 7377 5 system system NN cord-005453-4057qib7 7377 6 , , , cord-005453-4057qib7 7377 7 ESCs esc NNS cord-005453-4057qib7 7377 8 in in IN cord-005453-4057qib7 7377 9 3D 3d JJ cord-005453-4057qib7 7377 10 culture culture NN cord-005453-4057qib7 7377 11 system system NN cord-005453-4057qib7 7377 12 differentiated differentiate VBD cord-005453-4057qib7 7377 13 more more RBR cord-005453-4057qib7 7377 14 potently potently RB cord-005453-4057qib7 7377 15 . . . cord-005453-4057qib7 7378 1 The the DT cord-005453-4057qib7 7378 2 differentiated differentiated JJ cord-005453-4057qib7 7378 3 cells cell NNS cord-005453-4057qib7 7378 4 from from IN cord-005453-4057qib7 7378 5 3D 3d JJ cord-005453-4057qib7 7378 6 system system NN cord-005453-4057qib7 7378 7 were be VBD cord-005453-4057qib7 7378 8 short short JJ cord-005453-4057qib7 7378 9 - - HYPH cord-005453-4057qib7 7378 10 term term NN cord-005453-4057qib7 7378 11 engrafted engraft VBN cord-005453-4057qib7 7378 12 in in IN cord-005453-4057qib7 7378 13 the the DT cord-005453-4057qib7 7378 14 NOG NOG NNP cord-005453-4057qib7 7378 15 mice mouse NNS cord-005453-4057qib7 7378 16 , , , cord-005453-4057qib7 7378 17 and and CC cord-005453-4057qib7 7378 18 myeloid myeloid NN cord-005453-4057qib7 7378 19 cells cell NNS cord-005453-4057qib7 7378 20 , , , cord-005453-4057qib7 7378 21 B b NN cord-005453-4057qib7 7378 22 cells cell NNS cord-005453-4057qib7 7378 23 and and CC cord-005453-4057qib7 7378 24 T t NN cord-005453-4057qib7 7378 25 cells cell NNS cord-005453-4057qib7 7378 26 could could MD cord-005453-4057qib7 7378 27 all all DT cord-005453-4057qib7 7378 28 be be VB cord-005453-4057qib7 7378 29 detected detect VBN cord-005453-4057qib7 7378 30 in in IN cord-005453-4057qib7 7378 31 peripheral peripheral JJ cord-005453-4057qib7 7378 32 blood blood NN cord-005453-4057qib7 7378 33 after after IN cord-005453-4057qib7 7378 34 transplantation transplantation NN cord-005453-4057qib7 7378 35 . . . cord-005453-4057qib7 7379 1 However however RB cord-005453-4057qib7 7379 2 , , , cord-005453-4057qib7 7379 3 the the DT cord-005453-4057qib7 7379 4 engraftment engraftment NN cord-005453-4057qib7 7379 5 was be VBD cord-005453-4057qib7 7379 6 not not RB cord-005453-4057qib7 7379 7 obtained obtain VBN cord-005453-4057qib7 7379 8 in in IN cord-005453-4057qib7 7379 9 differentiated differentiated JJ cord-005453-4057qib7 7379 10 cells cell NNS cord-005453-4057qib7 7379 11 from from IN cord-005453-4057qib7 7379 12 EB eb NN cord-005453-4057qib7 7379 13 culture culture NN cord-005453-4057qib7 7379 14 system system NN cord-005453-4057qib7 7379 15 . . . cord-005453-4057qib7 7380 1 We -PRON- PRP cord-005453-4057qib7 7380 2 obtained obtain VBD cord-005453-4057qib7 7380 3 and and CC cord-005453-4057qib7 7380 4 analyzed analyze VBD cord-005453-4057qib7 7380 5 301 301 CD cord-005453-4057qib7 7380 6 ESCs esc NNS cord-005453-4057qib7 7380 7 , , , cord-005453-4057qib7 7380 8 554 554 CD cord-005453-4057qib7 7380 9 CD34 CD34 NNP cord-005453-4057qib7 7380 10 + + CC cord-005453-4057qib7 7380 11 cells cell NNS cord-005453-4057qib7 7380 12 from from IN cord-005453-4057qib7 7380 13 EB eb NN cord-005453-4057qib7 7380 14 culture culture NN cord-005453-4057qib7 7380 15 system system NN cord-005453-4057qib7 7380 16 , , , cord-005453-4057qib7 7380 17 440 440 CD cord-005453-4057qib7 7380 18 CD34 CD34 NNP cord-005453-4057qib7 7380 19 + + CC cord-005453-4057qib7 7380 20 cells cell NNS cord-005453-4057qib7 7380 21 from from IN cord-005453-4057qib7 7380 22 3D 3d JJ cord-005453-4057qib7 7380 23 culture culture NN cord-005453-4057qib7 7380 24 system system NN cord-005453-4057qib7 7380 25 , , , cord-005453-4057qib7 7380 26 and and CC cord-005453-4057qib7 7380 27 218 218 CD cord-005453-4057qib7 7380 28 CD34 CD34 NNP cord-005453-4057qib7 7380 29 + + CC cord-005453-4057qib7 7380 30 cells cell NNS cord-005453-4057qib7 7380 31 from from IN cord-005453-4057qib7 7380 32 mPBMCs mpbmcs CD cord-005453-4057qib7 7380 33 . . . cord-005453-4057qib7 7381 1 The the DT cord-005453-4057qib7 7381 2 cells cell NNS cord-005453-4057qib7 7381 3 were be VBD cord-005453-4057qib7 7381 4 divided divide VBN cord-005453-4057qib7 7381 5 into into IN cord-005453-4057qib7 7381 6 11 11 CD cord-005453-4057qib7 7381 7 cluters cluter NNS cord-005453-4057qib7 7381 8 ( ( -LRB- cord-005453-4057qib7 7381 9 Figure figure NN cord-005453-4057qib7 7381 10 1A 1a NN cord-005453-4057qib7 7381 11 ) ) -RRB- cord-005453-4057qib7 7381 12 . . . cord-005453-4057qib7 7382 1 In in IN cord-005453-4057qib7 7382 2 both both DT cord-005453-4057qib7 7382 3 differentiation differentiation NN cord-005453-4057qib7 7382 4 systems system NNS cord-005453-4057qib7 7382 5 , , , cord-005453-4057qib7 7382 6 the the DT cord-005453-4057qib7 7382 7 CD34 CD34 NNP cord-005453-4057qib7 7382 8 + + CC cord-005453-4057qib7 7382 9 cells cell NNS cord-005453-4057qib7 7382 10 from from IN cord-005453-4057qib7 7382 11 day day NN cord-005453-4057qib7 7382 12 7 7 CD cord-005453-4057qib7 7382 13 were be VBD cord-005453-4057qib7 7382 14 more more RBR cord-005453-4057qib7 7382 15 heterogeneous heterogeneous JJ cord-005453-4057qib7 7382 16 than than IN cord-005453-4057qib7 7382 17 CD34 CD34 NNP cord-005453-4057qib7 7382 18 + + CC cord-005453-4057qib7 7382 19 cells cell NNS cord-005453-4057qib7 7382 20 from from IN cord-005453-4057qib7 7382 21 day day NN cord-005453-4057qib7 7382 22 10 10 CD cord-005453-4057qib7 7382 23 and and CC cord-005453-4057qib7 7382 24 day day NN cord-005453-4057qib7 7382 25 14 14 CD cord-005453-4057qib7 7382 26 ( ( -LRB- cord-005453-4057qib7 7382 27 Figure figure NN cord-005453-4057qib7 7382 28 1B 1b CD cord-005453-4057qib7 7382 29 ) ) -RRB- cord-005453-4057qib7 7382 30 . . . cord-005453-4057qib7 7383 1 However however RB cord-005453-4057qib7 7383 2 , , , cord-005453-4057qib7 7383 3 CD34 CD34 NNP cord-005453-4057qib7 7383 4 + + CC cord-005453-4057qib7 7383 5 cells cell NNS cord-005453-4057qib7 7383 6 from from IN cord-005453-4057qib7 7383 7 mPBMCs mPBMCs NNP cord-005453-4057qib7 7383 8 were be VBD cord-005453-4057qib7 7383 9 more more RBR cord-005453-4057qib7 7383 10 homogeneous homogeneous JJ cord-005453-4057qib7 7383 11 , , , cord-005453-4057qib7 7383 12 probably probably RB cord-005453-4057qib7 7383 13 because because IN cord-005453-4057qib7 7383 14 the the DT cord-005453-4057qib7 7383 15 differentiated differentiated JJ cord-005453-4057qib7 7383 16 CD34 CD34 NNP cord-005453-4057qib7 7383 17 + + CC cord-005453-4057qib7 7383 18 cells cell NNS cord-005453-4057qib7 7383 19 contained contain VBD cord-005453-4057qib7 7383 20 several several JJ cord-005453-4057qib7 7383 21 cell cell NN cord-005453-4057qib7 7383 22 lineages lineage NNS cord-005453-4057qib7 7383 23 , , , cord-005453-4057qib7 7383 24 including include VBG cord-005453-4057qib7 7383 25 hematopoietic hematopoietic JJ cord-005453-4057qib7 7383 26 cells cell NNS cord-005453-4057qib7 7383 27 , , , cord-005453-4057qib7 7383 28 endothelial endothelial JJ cord-005453-4057qib7 7383 29 cells cell NNS cord-005453-4057qib7 7383 30 and and CC cord-005453-4057qib7 7383 31 mesenchymal mesenchymal JJ cord-005453-4057qib7 7383 32 cells cell NNS cord-005453-4057qib7 7383 33 . . . cord-005453-4057qib7 7384 1 There there EX cord-005453-4057qib7 7384 2 is be VBZ cord-005453-4057qib7 7384 3 transcriptional transcriptional JJ cord-005453-4057qib7 7384 4 overlap overlap NN cord-005453-4057qib7 7384 5 between between IN cord-005453-4057qib7 7384 6 individual individual JJ cord-005453-4057qib7 7384 7 CD34 CD34 NNP cord-005453-4057qib7 7384 8 + + CC cord-005453-4057qib7 7384 9 cells cell NNS cord-005453-4057qib7 7384 10 from from IN cord-005453-4057qib7 7384 11 EB EB NNP cord-005453-4057qib7 7384 12 and and CC cord-005453-4057qib7 7384 13 3D 3D NNP cord-005453-4057qib7 7384 14 culture culture NN cord-005453-4057qib7 7384 15 systems system NNS cord-005453-4057qib7 7384 16 . . . cord-005453-4057qib7 7385 1 However however RB cord-005453-4057qib7 7385 2 , , , cord-005453-4057qib7 7385 3 we -PRON- PRP cord-005453-4057qib7 7385 4 found find VBD cord-005453-4057qib7 7385 5 that that IN cord-005453-4057qib7 7385 6 cluster cluster NN cord-005453-4057qib7 7385 7 3 3 CD cord-005453-4057qib7 7385 8 , , , cord-005453-4057qib7 7385 9 which which WDT cord-005453-4057qib7 7385 10 is be VBZ cord-005453-4057qib7 7385 11 composed compose VBN cord-005453-4057qib7 7385 12 mainly mainly RB cord-005453-4057qib7 7385 13 of of IN cord-005453-4057qib7 7385 14 CD34 CD34 NNP cord-005453-4057qib7 7385 15 + + CC cord-005453-4057qib7 7385 16 cells cell NNS cord-005453-4057qib7 7385 17 from from IN cord-005453-4057qib7 7385 18 3D 3D NNP cord-005453-4057qib7 7385 19 at at IN cord-005453-4057qib7 7385 20 day day NN cord-005453-4057qib7 7385 21 14 14 CD cord-005453-4057qib7 7385 22 and and CC cord-005453-4057qib7 7385 23 day day NN cord-005453-4057qib7 7385 24 10 10 CD cord-005453-4057qib7 7385 25 , , , cord-005453-4057qib7 7385 26 expressed express VBD cord-005453-4057qib7 7385 27 similar similar JJ cord-005453-4057qib7 7385 28 level level NN cord-005453-4057qib7 7385 29 of of IN cord-005453-4057qib7 7385 30 several several JJ cord-005453-4057qib7 7385 31 hematopoietic hematopoietic JJ cord-005453-4057qib7 7385 32 regulator regulator NN cord-005453-4057qib7 7385 33 as as IN cord-005453-4057qib7 7385 34 HSC HSC NNP cord-005453-4057qib7 7385 35 , , , cord-005453-4057qib7 7385 36 such such JJ cord-005453-4057qib7 7385 37 as as IN cord-005453-4057qib7 7385 38 TAL1 TAL1 NNP cord-005453-4057qib7 7385 39 , , , cord-005453-4057qib7 7385 40 LMO2 LMO2 NNP cord-005453-4057qib7 7385 41 , , , cord-005453-4057qib7 7385 42 ERG ERG NNP cord-005453-4057qib7 7385 43 ( ( -LRB- cord-005453-4057qib7 7385 44 Figure Figure NNP cord-005453-4057qib7 7385 45 1C 1c NN cord-005453-4057qib7 7385 46 ) ) -RRB- cord-005453-4057qib7 7385 47 . . . cord-005453-4057qib7 7386 1 The the DT cord-005453-4057qib7 7386 2 cluster cluster NN cord-005453-4057qib7 7386 3 6 6 CD cord-005453-4057qib7 7386 4 , , , cord-005453-4057qib7 7386 5 which which WDT cord-005453-4057qib7 7386 6 is be VBZ cord-005453-4057qib7 7386 7 almost almost RB cord-005453-4057qib7 7386 8 the the DT cord-005453-4057qib7 7386 9 CD34 CD34 NNP cord-005453-4057qib7 7386 10 + + CC cord-005453-4057qib7 7386 11 cells cell NNS cord-005453-4057qib7 7386 12 from from IN cord-005453-4057qib7 7386 13 3D 3D NNP cord-005453-4057qib7 7386 14 at at IN cord-005453-4057qib7 7386 15 day day NN cord-005453-4057qib7 7386 16 7 7 CD cord-005453-4057qib7 7386 17 , , , cord-005453-4057qib7 7386 18 also also RB cord-005453-4057qib7 7386 19 expressed express VBD cord-005453-4057qib7 7386 20 the the DT cord-005453-4057qib7 7386 21 highest high JJS cord-005453-4057qib7 7386 22 GATA2 GATA2 NNS cord-005453-4057qib7 7386 23 among among IN cord-005453-4057qib7 7386 24 the the DT cord-005453-4057qib7 7386 25 clusters cluster NNS cord-005453-4057qib7 7386 26 from from IN cord-005453-4057qib7 7386 27 differentiated differentiated JJ cord-005453-4057qib7 7386 28 cells cell NNS cord-005453-4057qib7 7386 29 ( ( -LRB- cord-005453-4057qib7 7386 30 Figure figure NN cord-005453-4057qib7 7386 31 1C 1c NN cord-005453-4057qib7 7386 32 ) ) -RRB- cord-005453-4057qib7 7386 33 . . . cord-005453-4057qib7 7387 1 Conclusions conclusion NNS cord-005453-4057qib7 7387 2 : : : cord-005453-4057qib7 7388 1 Our -PRON- PRP$ cord-005453-4057qib7 7388 2 study study NN cord-005453-4057qib7 7388 3 demonstrates demonstrate VBZ cord-005453-4057qib7 7388 4 that that IN cord-005453-4057qib7 7388 5 3D 3d JJ cord-005453-4057qib7 7388 6 hydrogel hydrogel NN cord-005453-4057qib7 7388 7 culture culture NN cord-005453-4057qib7 7388 8 system system NN cord-005453-4057qib7 7388 9 facilitates facilitate VBZ cord-005453-4057qib7 7388 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 7388 11 specification specification NN cord-005453-4057qib7 7388 12 of of IN cord-005453-4057qib7 7388 13 ESCs esc NNS cord-005453-4057qib7 7388 14 . . . cord-005453-4057qib7 7389 1 Disclosure disclosure NN cord-005453-4057qib7 7389 2 : : : cord-005453-4057qib7 7389 3 Nothing nothing NN cord-005453-4057qib7 7389 4 to to TO cord-005453-4057qib7 7389 5 declare declare VB cord-005453-4057qib7 7389 6 Higher high JJR cord-005453-4057qib7 7389 7 CD34 CD34 NNP cord-005453-4057qib7 7389 8 + + CC cord-005453-4057qib7 7389 9 cell cell NN cord-005453-4057qib7 7389 10 dose dose NN cord-005453-4057qib7 7389 11 increases increase VBZ cord-005453-4057qib7 7389 12 overall overall JJ cord-005453-4057qib7 7389 13 survival survival NN cord-005453-4057qib7 7389 14 in in IN cord-005453-4057qib7 7389 15 the the DT cord-005453-4057qib7 7389 16 setting setting NN cord-005453-4057qib7 7389 17 of of IN cord-005453-4057qib7 7389 18 dual dual JJ cord-005453-4057qib7 7389 19 T t NN cord-005453-4057qib7 7389 20 - - HYPH cord-005453-4057qib7 7389 21 lymphocyte lymphocyte NN cord-005453-4057qib7 7389 22 suppression suppression NN cord-005453-4057qib7 7389 23 with with IN cord-005453-4057qib7 7389 24 ATG ATG NNP cord-005453-4057qib7 7389 25 and and CC cord-005453-4057qib7 7389 26 PTCY PTCY NNP cord-005453-4057qib7 7389 27 in in IN cord-005453-4057qib7 7389 28 matched match VBN cord-005453-4057qib7 7389 29 related related JJ cord-005453-4057qib7 7389 30 and and CC cord-005453-4057qib7 7389 31 unrelated unrelated JJ cord-005453-4057qib7 7389 32 donor donor NN cord-005453-4057qib7 7390 1 alloSCT alloSCT NNP cord-005453-4057qib7 7390 2 Background Background NNP cord-005453-4057qib7 7390 3 : : : cord-005453-4057qib7 7391 1 There there EX cord-005453-4057qib7 7391 2 is be VBZ cord-005453-4057qib7 7391 3 no no DT cord-005453-4057qib7 7391 4 consensus consensus NN cord-005453-4057qib7 7391 5 on on IN cord-005453-4057qib7 7391 6 the the DT cord-005453-4057qib7 7391 7 CD34 CD34 NNP cord-005453-4057qib7 7391 8 + + CC cord-005453-4057qib7 7391 9 donor donor NN cord-005453-4057qib7 7391 10 cell cell NN cord-005453-4057qib7 7391 11 numbers number NNS cord-005453-4057qib7 7391 12 required require VBN cord-005453-4057qib7 7391 13 for for IN cord-005453-4057qib7 7391 14 optimal optimal JJ cord-005453-4057qib7 7391 15 outcomes outcome NNS cord-005453-4057qib7 7391 16 in in IN cord-005453-4057qib7 7391 17 allogeneic allogeneic NN cord-005453-4057qib7 7391 18 stem stem NN cord-005453-4057qib7 7391 19 cell cell NN cord-005453-4057qib7 7391 20 transplant transplant NN cord-005453-4057qib7 7391 21 ( ( -LRB- cord-005453-4057qib7 7391 22 alloSCT alloSCT NNP cord-005453-4057qib7 7391 23 ) ) -RRB- cord-005453-4057qib7 7391 24 . . . cord-005453-4057qib7 7392 1 There there EX cord-005453-4057qib7 7392 2 is be VBZ cord-005453-4057qib7 7392 3 controversy controversy NN cord-005453-4057qib7 7392 4 on on IN cord-005453-4057qib7 7392 5 the the DT cord-005453-4057qib7 7392 6 benefits benefit NNS cord-005453-4057qib7 7392 7 or or CC cord-005453-4057qib7 7392 8 harm harm NN cord-005453-4057qib7 7392 9 in in IN cord-005453-4057qib7 7392 10 higher high JJR cord-005453-4057qib7 7392 11 cell cell NN cord-005453-4057qib7 7392 12 dose dose NN cord-005453-4057qib7 7392 13 for for IN cord-005453-4057qib7 7392 14 alloSCT alloSCT NNP cord-005453-4057qib7 7392 15 . . . cord-005453-4057qib7 7393 1 This this DT cord-005453-4057qib7 7393 2 study study NN cord-005453-4057qib7 7393 3 aims aim VBZ cord-005453-4057qib7 7393 4 to to TO cord-005453-4057qib7 7393 5 evaluate evaluate VB cord-005453-4057qib7 7393 6 the the DT cord-005453-4057qib7 7393 7 impact impact NN cord-005453-4057qib7 7393 8 of of IN cord-005453-4057qib7 7393 9 CD34 CD34 NNP cord-005453-4057qib7 7393 10 + + CC cord-005453-4057qib7 7393 11 cell cell NN cord-005453-4057qib7 7393 12 dose dose NN cord-005453-4057qib7 7393 13 in in IN cord-005453-4057qib7 7393 14 alloSCT alloSCT NNP cord-005453-4057qib7 7393 15 patients patient NNS cord-005453-4057qib7 7393 16 receiving receive VBG cord-005453-4057qib7 7393 17 reduced reduced JJ cord-005453-4057qib7 7393 18 intensity intensity NN cord-005453-4057qib7 7393 19 conditioning conditioning NN cord-005453-4057qib7 7393 20 ( ( -LRB- cord-005453-4057qib7 7393 21 RIC RIC NNP cord-005453-4057qib7 7393 22 ) ) -RRB- cord-005453-4057qib7 7393 23 combined combine VBN cord-005453-4057qib7 7393 24 with with IN cord-005453-4057qib7 7393 25 anti anti JJ cord-005453-4057qib7 7393 26 - - JJ cord-005453-4057qib7 7393 27 thymoglobulin thymoglobulin JJ cord-005453-4057qib7 7393 28 ( ( -LRB- cord-005453-4057qib7 7393 29 ATG ATG NNP cord-005453-4057qib7 7393 30 ) ) -RRB- cord-005453-4057qib7 7393 31 and and CC cord-005453-4057qib7 7393 32 posttransplant posttransplant NNP cord-005453-4057qib7 7393 33 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 7393 34 ( ( -LRB- cord-005453-4057qib7 7393 35 PTCy PTCy NNP cord-005453-4057qib7 7393 36 ) ) -RRB- cord-005453-4057qib7 7393 37 using use VBG cord-005453-4057qib7 7393 38 related relate VBN cord-005453-4057qib7 7393 39 ( ( -LRB- cord-005453-4057qib7 7393 40 MRD MRD NNP cord-005453-4057qib7 7393 41 ) ) -RRB- cord-005453-4057qib7 7393 42 and and CC cord-005453-4057qib7 7393 43 10/10 10/10 CD cord-005453-4057qib7 7393 44 and and CC cord-005453-4057qib7 7393 45 9/10 9/10 CD cord-005453-4057qib7 7393 46 matched match VBN cord-005453-4057qib7 7393 47 unrelated unrelated JJ cord-005453-4057qib7 7393 48 donors donor NNS cord-005453-4057qib7 7393 49 ( ( -LRB- cord-005453-4057qib7 7393 50 MUD mud NN cord-005453-4057qib7 7393 51 ) ) -RRB- cord-005453-4057qib7 7393 52 . . . cord-005453-4057qib7 7394 1 Methods method NNS cord-005453-4057qib7 7394 2 : : : cord-005453-4057qib7 7394 3 This this DT cord-005453-4057qib7 7394 4 is be VBZ cord-005453-4057qib7 7394 5 a a DT cord-005453-4057qib7 7394 6 single single JJ cord-005453-4057qib7 7394 7 - - HYPH cord-005453-4057qib7 7394 8 centre centre NN cord-005453-4057qib7 7394 9 retrospective retrospective JJ cord-005453-4057qib7 7394 10 analysis analysis NN cord-005453-4057qib7 7394 11 of of IN cord-005453-4057qib7 7394 12 140 140 CD cord-005453-4057qib7 7394 13 adult adult NN cord-005453-4057qib7 7394 14 patients patient NNS cord-005453-4057qib7 7394 15 who who WP cord-005453-4057qib7 7394 16 received receive VBD cord-005453-4057qib7 7394 17 alloSCT alloSCT NNP cord-005453-4057qib7 7394 18 for for IN cord-005453-4057qib7 7394 19 hematologic hematologic JJ cord-005453-4057qib7 7394 20 malignancies malignancy NNS cord-005453-4057qib7 7394 21 between between IN cord-005453-4057qib7 7394 22 October October NNP cord-005453-4057qib7 7394 23 2015 2015 CD cord-005453-4057qib7 7394 24 and and CC cord-005453-4057qib7 7394 25 May May NNP cord-005453-4057qib7 7394 26 2018 2018 CD cord-005453-4057qib7 7394 27 . . . cord-005453-4057qib7 7395 1 All all DT cord-005453-4057qib7 7395 2 received receive VBD cord-005453-4057qib7 7395 3 RIC RIC NNP cord-005453-4057qib7 7395 4 using use VBG cord-005453-4057qib7 7395 5 fludarabine fludarabine NN cord-005453-4057qib7 7395 6 ( ( -LRB- cord-005453-4057qib7 7395 7 30mg 30mg NNP cord-005453-4057qib7 7395 8 / / SYM cord-005453-4057qib7 7395 9 m m NN cord-005453-4057qib7 7395 10 2 2 CD cord-005453-4057qib7 7395 11 /day /day CD cord-005453-4057qib7 7395 12 : : : cord-005453-4057qib7 7395 13 day day NN cord-005453-4057qib7 7395 14 -5 -5 JJ cord-005453-4057qib7 7395 15 to to IN cord-005453-4057qib7 7395 16 -2 -2 NNP cord-005453-4057qib7 7395 17 ) ) -RRB- cord-005453-4057qib7 7395 18 , , , cord-005453-4057qib7 7395 19 busulfan busulfan NNP cord-005453-4057qib7 7395 20 ( ( -LRB- cord-005453-4057qib7 7395 21 3.2kg 3.2kg NNP cord-005453-4057qib7 7395 22 / / SYM cord-005453-4057qib7 7395 23 m m NN cord-005453-4057qib7 7395 24 2 2 CD cord-005453-4057qib7 7395 25 /day /day CD cord-005453-4057qib7 7395 26 : : : cord-005453-4057qib7 7395 27 day day NN cord-005453-4057qib7 7395 28 -3 -3 NNP cord-005453-4057qib7 7395 29 and and CC cord-005453-4057qib7 7395 30 -2 -2 LS cord-005453-4057qib7 7395 31 ) ) -RRB- cord-005453-4057qib7 7395 32 and and CC cord-005453-4057qib7 7395 33 total total JJ cord-005453-4057qib7 7395 34 body body NN cord-005453-4057qib7 7395 35 irradiation irradiation NN cord-005453-4057qib7 7395 36 ( ( -LRB- cord-005453-4057qib7 7395 37 200 200 CD cord-005453-4057qib7 7395 38 cGy cGy NNS cord-005453-4057qib7 7395 39 : : : cord-005453-4057qib7 7395 40 day day NN cord-005453-4057qib7 7395 41 -1 -1 NN cord-005453-4057qib7 7395 42 ) ) -RRB- cord-005453-4057qib7 7395 43 . . . cord-005453-4057qib7 7396 1 All all DT cord-005453-4057qib7 7396 2 patients patient NNS cord-005453-4057qib7 7396 3 also also RB cord-005453-4057qib7 7396 4 received receive VBD cord-005453-4057qib7 7396 5 rabbit rabbit NN cord-005453-4057qib7 7396 6 - - HYPH cord-005453-4057qib7 7396 7 ATG ATG NNP cord-005453-4057qib7 7396 8 ( ( -LRB- cord-005453-4057qib7 7396 9 4.5 4.5 CD cord-005453-4057qib7 7396 10 mg mg NNP cord-005453-4057qib7 7396 11 / / SYM cord-005453-4057qib7 7396 12 kg kg NNP cord-005453-4057qib7 7396 13 : : : cord-005453-4057qib7 7396 14 day day NN cord-005453-4057qib7 7396 15 -3 -3 NNP cord-005453-4057qib7 7396 16 to to IN cord-005453-4057qib7 7396 17 -1 -1 NN cord-005453-4057qib7 7396 18 ) ) -RRB- cord-005453-4057qib7 7396 19 , , , cord-005453-4057qib7 7396 20 PTCy PTCy NNPS cord-005453-4057qib7 7396 21 ( ( -LRB- cord-005453-4057qib7 7396 22 50mg 50mg NNP cord-005453-4057qib7 7396 23 / / SYM cord-005453-4057qib7 7396 24 kg kg NN cord-005453-4057qib7 7396 25 / / SYM cord-005453-4057qib7 7396 26 day day NN cord-005453-4057qib7 7396 27 : : : cord-005453-4057qib7 7396 28 day day NN cord-005453-4057qib7 7396 29 +3,+4 +3,+4 NNS cord-005453-4057qib7 7396 30 ) ) -RRB- cord-005453-4057qib7 7396 31 and and CC cord-005453-4057qib7 7396 32 cyclosporine cyclosporine NN cord-005453-4057qib7 7396 33 ( ( -LRB- cord-005453-4057qib7 7396 34 from from IN cord-005453-4057qib7 7396 35 day day NN cord-005453-4057qib7 7396 36 +5 +5 NN cord-005453-4057qib7 7396 37 ) ) -RRB- cord-005453-4057qib7 7396 38 . . . cord-005453-4057qib7 7397 1 Unmanipulated unmanipulated JJ cord-005453-4057qib7 7397 2 peripheral peripheral JJ cord-005453-4057qib7 7397 3 blood blood NN cord-005453-4057qib7 7397 4 stem stem NN cord-005453-4057qib7 7397 5 cells cell NNS cord-005453-4057qib7 7397 6 were be VBD cord-005453-4057qib7 7397 7 infused infuse VBN cord-005453-4057qib7 7397 8 on on IN cord-005453-4057qib7 7397 9 day day NN cord-005453-4057qib7 7397 10 0 0 CD cord-005453-4057qib7 7397 11 . . . cord-005453-4057qib7 7398 1 Analyses analysis NNS cord-005453-4057qib7 7398 2 were be VBD cord-005453-4057qib7 7398 3 done do VBN cord-005453-4057qib7 7398 4 using use VBG cord-005453-4057qib7 7398 5 2 2 CD cord-005453-4057qib7 7398 6 thresholds threshold NNS cord-005453-4057qib7 7398 7 : : : cord-005453-4057qib7 7398 8 ( ( -LRB- cord-005453-4057qib7 7398 9 1 1 LS cord-005453-4057qib7 7398 10 ) ) -RRB- cord-005453-4057qib7 7398 11 an an DT cord-005453-4057qib7 7398 12 arbitrary arbitrary JJ cord-005453-4057qib7 7398 13 CD34 CD34 NNP cord-005453-4057qib7 7398 14 + + CC cord-005453-4057qib7 7398 15 cell cell NN cord-005453-4057qib7 7398 16 dose dose NN cord-005453-4057qib7 7398 17 of of IN cord-005453-4057qib7 7398 18 6 6 CD cord-005453-4057qib7 7398 19 x10 x10 CD cord-005453-4057qib7 7398 20 6 6 CD cord-005453-4057qib7 7399 1 /kg /kg . cord-005453-4057qib7 7400 1 ( ( -LRB- cord-005453-4057qib7 7400 2 as as IN cord-005453-4057qib7 7400 3 this this DT cord-005453-4057qib7 7400 4 was be VBD cord-005453-4057qib7 7400 5 our -PRON- PRP$ cord-005453-4057qib7 7400 6 target target NN cord-005453-4057qib7 7400 7 dose dose NN cord-005453-4057qib7 7400 8 ) ) -RRB- cord-005453-4057qib7 7400 9 and and CC cord-005453-4057qib7 7400 10 ( ( -LRB- cord-005453-4057qib7 7400 11 2 2 LS cord-005453-4057qib7 7400 12 ) ) -RRB- cord-005453-4057qib7 7400 13 cell cell NN cord-005453-4057qib7 7400 14 dose dose NN cord-005453-4057qib7 7400 15 according accord VBG cord-005453-4057qib7 7400 16 to to IN cord-005453-4057qib7 7400 17 quartiles quartile NNS cord-005453-4057qib7 7400 18 ( ( -LRB- cord-005453-4057qib7 7400 19 < < NNP cord-005453-4057qib7 7400 20 5.67 5.67 CD cord-005453-4057qib7 7400 21 , , , cord-005453-4057qib7 7400 22 5.67 5.67 CD cord-005453-4057qib7 7400 23 - - SYM cord-005453-4057qib7 7400 24 7.98 7.98 CD cord-005453-4057qib7 7400 25 , , , cord-005453-4057qib7 7400 26 7.99 7.99 CD cord-005453-4057qib7 7400 27 - - SYM cord-005453-4057qib7 7400 28 11.34 11.34 CD cord-005453-4057qib7 7400 29 and and CC cord-005453-4057qib7 7400 30 ≥ ≥ CD cord-005453-4057qib7 7400 31 11.35 11.35 CD cord-005453-4057qib7 7400 32 x10 x10 NN cord-005453-4057qib7 7400 33 6 6 CD cord-005453-4057qib7 7400 34 /kg /kg . cord-005453-4057qib7 7400 35 ) ) -RRB- cord-005453-4057qib7 7400 36 . . . cord-005453-4057qib7 7401 1 Results result NNS cord-005453-4057qib7 7401 2 : : : cord-005453-4057qib7 7402 1 Median median JJ cord-005453-4057qib7 7402 2 CD34 CD34 NNP cord-005453-4057qib7 7402 3 + + CC cord-005453-4057qib7 7402 4 cell cell NN cord-005453-4057qib7 7402 5 dose dose NN cord-005453-4057qib7 7402 6 was be VBD cord-005453-4057qib7 7402 7 7.98 7.98 CD cord-005453-4057qib7 7402 8 x10 x10 CD cord-005453-4057qib7 7402 9 6 6 CD cord-005453-4057qib7 7403 1 /kg /kg NFP cord-005453-4057qib7 7403 2 . . . cord-005453-4057qib7 7404 1 Median median JJ cord-005453-4057qib7 7404 2 follow follow VBP cord-005453-4057qib7 7404 3 up up RP cord-005453-4057qib7 7404 4 was be VBD cord-005453-4057qib7 7404 5 19 19 CD cord-005453-4057qib7 7404 6 months month NNS cord-005453-4057qib7 7404 7 ( ( -LRB- cord-005453-4057qib7 7404 8 range range VBP cord-005453-4057qib7 7404 9 5 5 CD cord-005453-4057qib7 7404 10 - - SYM cord-005453-4057qib7 7404 11 35 35 CD cord-005453-4057qib7 7404 12 ) ) -RRB- cord-005453-4057qib7 7404 13 . . . cord-005453-4057qib7 7405 1 Median median JJ cord-005453-4057qib7 7405 2 neutrophil neutrophil NN cord-005453-4057qib7 7405 3 engraftment engraftment NN cord-005453-4057qib7 7405 4 was be VBD cord-005453-4057qib7 7405 5 16 16 CD cord-005453-4057qib7 7406 1 ( ( -LRB- cord-005453-4057qib7 7406 2 range range NNP cord-005453-4057qib7 7406 3 13 13 CD cord-005453-4057qib7 7406 4 - - SYM cord-005453-4057qib7 7406 5 31 31 CD cord-005453-4057qib7 7406 6 ) ) -RRB- cord-005453-4057qib7 7406 7 days day NNS cord-005453-4057qib7 7406 8 and and CC cord-005453-4057qib7 7406 9 platelet platelet NN cord-005453-4057qib7 7406 10 engraftment engraftment NN cord-005453-4057qib7 7406 11 was be VBD cord-005453-4057qib7 7406 12 21 21 CD cord-005453-4057qib7 7407 1 ( ( -LRB- cord-005453-4057qib7 7407 2 range range NNP cord-005453-4057qib7 7407 3 11 11 CD cord-005453-4057qib7 7407 4 - - SYM cord-005453-4057qib7 7407 5 83 83 CD cord-005453-4057qib7 7407 6 ) ) -RRB- cord-005453-4057qib7 7407 7 days day NNS cord-005453-4057qib7 7407 8 . . . cord-005453-4057qib7 7408 1 A a DT cord-005453-4057qib7 7408 2 cell cell NN cord-005453-4057qib7 7408 3 dose dose NN cord-005453-4057qib7 7408 4 greater great JJR cord-005453-4057qib7 7408 5 than than IN cord-005453-4057qib7 7408 6 6 6 CD cord-005453-4057qib7 7408 7 x10 x10 CD cord-005453-4057qib7 7408 8 6 6 CD cord-005453-4057qib7 7409 1 /kg /kg NNP cord-005453-4057qib7 7409 2 was be VBD cord-005453-4057qib7 7409 3 associated associate VBN cord-005453-4057qib7 7409 4 with with IN cord-005453-4057qib7 7409 5 an an DT cord-005453-4057qib7 7409 6 increased increased JJ cord-005453-4057qib7 7409 7 overall overall JJ cord-005453-4057qib7 7409 8 survival survival NN cord-005453-4057qib7 7409 9 ( ( -LRB- cord-005453-4057qib7 7409 10 OS OS NNP cord-005453-4057qib7 7409 11 ) ) -RRB- cord-005453-4057qib7 7409 12 at at IN cord-005453-4057qib7 7409 13 1 1 CD cord-005453-4057qib7 7409 14 year year NN cord-005453-4057qib7 7409 15 ( ( -LRB- cord-005453-4057qib7 7409 16 71.3 71.3 CD cord-005453-4057qib7 7409 17 % % NN cord-005453-4057qib7 7409 18 ; ; : cord-005453-4057qib7 7409 19 95 95 CD cord-005453-4057qib7 7409 20 % % NN cord-005453-4057qib7 7409 21 CI CI NNP cord-005453-4057qib7 7409 22 , , , cord-005453-4057qib7 7409 23 62.3 62.3 CD cord-005453-4057qib7 7409 24 - - HYPH cord-005453-4057qib7 7409 25 80.3 80.3 CD cord-005453-4057qib7 7409 26 vs vs IN cord-005453-4057qib7 7409 27 46.7 46.7 CD cord-005453-4057qib7 7409 28 % % NN cord-005453-4057qib7 7409 29 ; ; : cord-005453-4057qib7 7409 30 95 95 CD cord-005453-4057qib7 7409 31 % % NN cord-005453-4057qib7 7409 32 CI CI NNP cord-005453-4057qib7 7409 33 30.3 30.3 CD cord-005453-4057qib7 7409 34 - - HYPH cord-005453-4057qib7 7409 35 63.1 63.1 CD cord-005453-4057qib7 7409 36 ; ; : cord-005453-4057qib7 7409 37 p=0.018 p=0.018 ADD cord-005453-4057qib7 7410 1 , , , cord-005453-4057qib7 7410 2 Figure figure NN cord-005453-4057qib7 7410 3 1 1 CD cord-005453-4057qib7 7410 4 ) ) -RRB- cord-005453-4057qib7 7410 5 . . . cord-005453-4057qib7 7411 1 The the DT cord-005453-4057qib7 7411 2 higher high JJR cord-005453-4057qib7 7411 3 dose dose NN cord-005453-4057qib7 7411 4 was be VBD cord-005453-4057qib7 7411 5 also also RB cord-005453-4057qib7 7411 6 associated associate VBN cord-005453-4057qib7 7411 7 with with IN cord-005453-4057qib7 7411 8 shorter short JJR cord-005453-4057qib7 7411 9 platelet platelet NN cord-005453-4057qib7 7411 10 engraftment engraftment NN cord-005453-4057qib7 7411 11 time time NN cord-005453-4057qib7 7411 12 ( ( -LRB- cord-005453-4057qib7 7411 13 p=0.016 p=0.016 RB cord-005453-4057qib7 7411 14 , , , cord-005453-4057qib7 7411 15 Figure figure NN cord-005453-4057qib7 7411 16 2 2 CD cord-005453-4057qib7 7411 17 ) ) -RRB- cord-005453-4057qib7 7411 18 . . . cord-005453-4057qib7 7412 1 There there EX cord-005453-4057qib7 7412 2 was be VBD cord-005453-4057qib7 7412 3 no no DT cord-005453-4057qib7 7412 4 significant significant JJ cord-005453-4057qib7 7412 5 difference difference NN cord-005453-4057qib7 7412 6 in in IN cord-005453-4057qib7 7412 7 neutrophil neutrophil NN cord-005453-4057qib7 7412 8 engraftment engraftment NN cord-005453-4057qib7 7412 9 , , , cord-005453-4057qib7 7412 10 nonrelapse nonrelapse JJ cord-005453-4057qib7 7412 11 mortality mortality NN cord-005453-4057qib7 7412 12 ( ( -LRB- cord-005453-4057qib7 7412 13 NRM NRM NNP cord-005453-4057qib7 7412 14 ) ) -RRB- cord-005453-4057qib7 7412 15 , , , cord-005453-4057qib7 7412 16 relapse relapse VB cord-005453-4057qib7 7412 17 free free JJ cord-005453-4057qib7 7412 18 survival survival NN cord-005453-4057qib7 7412 19 ( ( -LRB- cord-005453-4057qib7 7412 20 RFS RFS NNP cord-005453-4057qib7 7412 21 ) ) -RRB- cord-005453-4057qib7 7412 22 , , , cord-005453-4057qib7 7412 23 Grade Grade NNP cord-005453-4057qib7 7412 24 II II NNP cord-005453-4057qib7 7412 25 - - HYPH cord-005453-4057qib7 7412 26 IV IV NNP cord-005453-4057qib7 7412 27 acute acute JJ cord-005453-4057qib7 7412 28 graft graft NN cord-005453-4057qib7 7412 29 versus versus IN cord-005453-4057qib7 7412 30 host host NN cord-005453-4057qib7 7412 31 disease disease NN cord-005453-4057qib7 7412 32 ( ( -LRB- cord-005453-4057qib7 7412 33 aGVHD aGVHD NNP cord-005453-4057qib7 7412 34 ) ) -RRB- cord-005453-4057qib7 7412 35 and and CC cord-005453-4057qib7 7412 36 moderate moderate JJ cord-005453-4057qib7 7412 37 to to IN cord-005453-4057qib7 7412 38 severe severe JJ cord-005453-4057qib7 7412 39 chronic chronic JJ cord-005453-4057qib7 7412 40 graft graft NN cord-005453-4057qib7 7412 41 versus versus IN cord-005453-4057qib7 7412 42 host host NN cord-005453-4057qib7 7412 43 disease disease NN cord-005453-4057qib7 7412 44 ( ( -LRB- cord-005453-4057qib7 7412 45 cGVHD cGVHD NNP cord-005453-4057qib7 7412 46 ) ) -RRB- cord-005453-4057qib7 7412 47 , , . cord-005453-4057qib7 7413 1 ( ( -LRB- cord-005453-4057qib7 7413 2 Table table NN cord-005453-4057qib7 7413 3 1 1 CD cord-005453-4057qib7 7413 4 ) ) -RRB- cord-005453-4057qib7 7413 5 . . . cord-005453-4057qib7 7414 1 Analyses analysis NNS cord-005453-4057qib7 7414 2 using use VBG cord-005453-4057qib7 7414 3 quartile quartile NN cord-005453-4057qib7 7414 4 cell cell NN cord-005453-4057qib7 7414 5 dose dose NN cord-005453-4057qib7 7414 6 thresholds threshold NNS cord-005453-4057qib7 7414 7 showed show VBD cord-005453-4057qib7 7414 8 a a DT cord-005453-4057qib7 7414 9 trend trend NN cord-005453-4057qib7 7414 10 towards towards IN cord-005453-4057qib7 7414 11 decreased decrease VBN cord-005453-4057qib7 7414 12 OS OS NNP cord-005453-4057qib7 7414 13 with with IN cord-005453-4057qib7 7414 14 a a DT cord-005453-4057qib7 7414 15 cell cell NN cord-005453-4057qib7 7414 16 dose dose NN cord-005453-4057qib7 7414 17 of of IN cord-005453-4057qib7 7414 18 < < NNP cord-005453-4057qib7 7414 19 5.67x10 5.67x10 CD cord-005453-4057qib7 7414 20 ^ ^ SYM cord-005453-4057qib7 7414 21 6 6 CD cord-005453-4057qib7 7414 22 / / SYM cord-005453-4057qib7 7414 23 kg kg NNS cord-005453-4057qib7 7414 24 , , , cord-005453-4057qib7 7414 25 however however RB cord-005453-4057qib7 7414 26 this this DT cord-005453-4057qib7 7414 27 was be VBD cord-005453-4057qib7 7414 28 not not RB cord-005453-4057qib7 7414 29 statistically statistically RB cord-005453-4057qib7 7414 30 significant significant JJ cord-005453-4057qib7 7415 1 ( ( -LRB- cord-005453-4057qib7 7415 2 Figure figure NN cord-005453-4057qib7 7415 3 1 1 CD cord-005453-4057qib7 7415 4 ) ) -RRB- cord-005453-4057qib7 7415 5 . . . cord-005453-4057qib7 7416 1 Higher high JJR cord-005453-4057qib7 7416 2 CD34 CD34 NNP cord-005453-4057qib7 7416 3 + + CC cord-005453-4057qib7 7416 4 cell cell NN cord-005453-4057qib7 7416 5 doses dose NNS cord-005453-4057qib7 7416 6 were be VBD cord-005453-4057qib7 7416 7 associated associate VBN cord-005453-4057qib7 7416 8 with with IN cord-005453-4057qib7 7416 9 shorter short JJR cord-005453-4057qib7 7416 10 platelet platelet NN cord-005453-4057qib7 7416 11 engraftment engraftment NN cord-005453-4057qib7 7416 12 time time NN cord-005453-4057qib7 7416 13 ( ( -LRB- cord-005453-4057qib7 7416 14 p=0.005 p=0.005 NNP cord-005453-4057qib7 7417 1 , , , cord-005453-4057qib7 7417 2 Figure figure NN cord-005453-4057qib7 7417 3 2 2 CD cord-005453-4057qib7 7417 4 ) ) -RRB- cord-005453-4057qib7 7417 5 . . . cord-005453-4057qib7 7418 1 There there EX cord-005453-4057qib7 7418 2 was be VBD cord-005453-4057qib7 7418 3 no no DT cord-005453-4057qib7 7418 4 significant significant JJ cord-005453-4057qib7 7418 5 difference difference NN cord-005453-4057qib7 7418 6 in in IN cord-005453-4057qib7 7418 7 neutrophil neutrophil NN cord-005453-4057qib7 7418 8 engraftment engraftment NN cord-005453-4057qib7 7418 9 , , , cord-005453-4057qib7 7418 10 NRM NRM NNP cord-005453-4057qib7 7418 11 , , , cord-005453-4057qib7 7418 12 RFS RFS NNP cord-005453-4057qib7 7418 13 , , , cord-005453-4057qib7 7418 14 aGVHD aGVHD NNP cord-005453-4057qib7 7418 15 and and CC cord-005453-4057qib7 7418 16 cGVHD cGVHD NNP cord-005453-4057qib7 7418 17 ( ( -LRB- cord-005453-4057qib7 7418 18 Table Table NNP cord-005453-4057qib7 7418 19 2 2 CD cord-005453-4057qib7 7418 20 ) ) -RRB- cord-005453-4057qib7 7418 21 . . . cord-005453-4057qib7 7419 1 Conclusions conclusion NNS cord-005453-4057qib7 7419 2 : : : cord-005453-4057qib7 7420 1 CD34 CD34 NNP cord-005453-4057qib7 7420 2 + + CC cord-005453-4057qib7 7420 3 cell cell NN cord-005453-4057qib7 7420 4 dose dose NN cord-005453-4057qib7 7420 5 greater great JJR cord-005453-4057qib7 7420 6 than than IN cord-005453-4057qib7 7420 7 6 6 CD cord-005453-4057qib7 7420 8 x10 x10 CD cord-005453-4057qib7 7420 9 6 6 CD cord-005453-4057qib7 7420 10 /kg /kg NFP cord-005453-4057qib7 7420 11 significantly significantly RB cord-005453-4057qib7 7420 12 increases increase VBZ cord-005453-4057qib7 7420 13 overall overall JJ cord-005453-4057qib7 7420 14 survival survival NN cord-005453-4057qib7 7420 15 in in IN cord-005453-4057qib7 7420 16 the the DT cord-005453-4057qib7 7420 17 setting setting NN cord-005453-4057qib7 7420 18 of of IN cord-005453-4057qib7 7420 19 RIC RIC NNP cord-005453-4057qib7 7420 20 and and CC cord-005453-4057qib7 7420 21 dual dual JJ cord-005453-4057qib7 7420 22 T t NN cord-005453-4057qib7 7420 23 - - HYPH cord-005453-4057qib7 7420 24 lymphocyte lymphocyte NN cord-005453-4057qib7 7420 25 suppression suppression NN cord-005453-4057qib7 7420 26 with with IN cord-005453-4057qib7 7420 27 ATG ATG NNP cord-005453-4057qib7 7420 28 and and CC cord-005453-4057qib7 7420 29 PTCy PTCy NNPS cord-005453-4057qib7 7420 30 in in IN cord-005453-4057qib7 7420 31 MRD MRD NNP cord-005453-4057qib7 7420 32 and and CC cord-005453-4057qib7 7420 33 MUD MUD NNP cord-005453-4057qib7 7420 34 alloHSCT alloHSCT NNP cord-005453-4057qib7 7420 35 . . . cord-005453-4057qib7 7421 1 Further further JJ cord-005453-4057qib7 7421 2 studies study NNS cord-005453-4057qib7 7421 3 in in IN cord-005453-4057qib7 7421 4 a a DT cord-005453-4057qib7 7421 5 larger large JJR cord-005453-4057qib7 7421 6 number number NN cord-005453-4057qib7 7421 7 of of IN cord-005453-4057qib7 7421 8 patients patient NNS cord-005453-4057qib7 7421 9 and and CC cord-005453-4057qib7 7421 10 longer long RBR cord-005453-4057qib7 7421 11 follow follow VB cord-005453-4057qib7 7421 12 up up RP cord-005453-4057qib7 7421 13 are be VBP cord-005453-4057qib7 7421 14 recommended recommend VBN cord-005453-4057qib7 7421 15 to to TO cord-005453-4057qib7 7421 16 validate validate VB cord-005453-4057qib7 7421 17 these these DT cord-005453-4057qib7 7421 18 findings finding NNS cord-005453-4057qib7 7421 19 . . . cord-005453-4057qib7 7422 1 Disclosure disclosure NN cord-005453-4057qib7 7422 2 Methods method NNS cord-005453-4057qib7 7422 3 : : : cord-005453-4057qib7 7422 4 Fifty fifty CD cord-005453-4057qib7 7422 5 two two CD cord-005453-4057qib7 7422 6 adult adult NN cord-005453-4057qib7 7422 7 patients patient NNS cord-005453-4057qib7 7422 8 were be VBD cord-005453-4057qib7 7422 9 included include VBN cord-005453-4057qib7 7422 10 . . . cord-005453-4057qib7 7423 1 Median median JJ cord-005453-4057qib7 7423 2 CD34 CD34 NNP cord-005453-4057qib7 7423 3 + + CC cord-005453-4057qib7 7423 4 cells cell NNS cord-005453-4057qib7 7423 5 requested request VBN cord-005453-4057qib7 7423 6 for for IN cord-005453-4057qib7 7423 7 infusion infusion NN cord-005453-4057qib7 7423 8 were be VBD cord-005453-4057qib7 7423 9 6x10 6x10 CD cord-005453-4057qib7 7423 10 ^ ^ SYM cord-005453-4057qib7 7423 11 6 6 CD cord-005453-4057qib7 7423 12 / / SYM cord-005453-4057qib7 7423 13 Kg Kg NNP cord-005453-4057qib7 7423 14 . . . cord-005453-4057qib7 7424 1 All all DT cord-005453-4057qib7 7424 2 patients patient NNS cord-005453-4057qib7 7424 3 received receive VBD cord-005453-4057qib7 7424 4 the the DT cord-005453-4057qib7 7424 5 same same JJ cord-005453-4057qib7 7424 6 RIC RIC NNP cord-005453-4057qib7 7424 7 regimen regimen NN cord-005453-4057qib7 7424 8 including include VBG cord-005453-4057qib7 7424 9 fludarabine fludarabine NN cord-005453-4057qib7 7424 10 ( ( -LRB- cord-005453-4057qib7 7424 11 30mg 30mg NNP cord-005453-4057qib7 7424 12 / / SYM cord-005453-4057qib7 7424 13 m2 m2 NNP cord-005453-4057qib7 7424 14 / / SYM cord-005453-4057qib7 7424 15 day day NN cord-005453-4057qib7 7424 16 day day NN cord-005453-4057qib7 7424 17 -5 -5 JJ cord-005453-4057qib7 7424 18 to to IN cord-005453-4057qib7 7424 19 -2 -2 NNP cord-005453-4057qib7 7424 20 ) ) -RRB- cord-005453-4057qib7 7424 21 , , , cord-005453-4057qib7 7424 22 busulfan busulfan NNP cord-005453-4057qib7 7424 23 ( ( -LRB- cord-005453-4057qib7 7424 24 3.2kg 3.2kg NNP cord-005453-4057qib7 7424 25 / / SYM cord-005453-4057qib7 7424 26 m2 m2 NNP cord-005453-4057qib7 7424 27 / / SYM cord-005453-4057qib7 7424 28 day day NN cord-005453-4057qib7 7424 29 day day NN cord-005453-4057qib7 7424 30 -3 -3 . cord-005453-4057qib7 7425 1 and and CC cord-005453-4057qib7 7425 2 -2 -2 LS cord-005453-4057qib7 7425 3 ) ) -RRB- cord-005453-4057qib7 7425 4 , , , cord-005453-4057qib7 7425 5 and and CC cord-005453-4057qib7 7425 6 total total JJ cord-005453-4057qib7 7425 7 body body NN cord-005453-4057qib7 7425 8 irradiation irradiation NN cord-005453-4057qib7 7425 9 ( ( -LRB- cord-005453-4057qib7 7425 10 200 200 CD cord-005453-4057qib7 7425 11 cGy cGy NNS cord-005453-4057qib7 7425 12 ) ) -RRB- cord-005453-4057qib7 7425 13 ( ( -LRB- cord-005453-4057qib7 7425 14 day day NN cord-005453-4057qib7 7425 15 -1 -1 NN cord-005453-4057qib7 7425 16 ) ) -RRB- cord-005453-4057qib7 7425 17 combined combine VBN cord-005453-4057qib7 7425 18 with with IN cord-005453-4057qib7 7425 19 rabbit rabbit NN cord-005453-4057qib7 7425 20 - - HYPH cord-005453-4057qib7 7425 21 ATG ATG NNP cord-005453-4057qib7 7425 22 ( ( -LRB- cord-005453-4057qib7 7425 23 4.5 4.5 CD cord-005453-4057qib7 7425 24 mg mg NNP cord-005453-4057qib7 7425 25 / / SYM cord-005453-4057qib7 7425 26 kg kg NNP cord-005453-4057qib7 7425 27 : : : cord-005453-4057qib7 7425 28 day day NN cord-005453-4057qib7 7425 29 -3 -3 NNP cord-005453-4057qib7 7425 30 to to IN cord-005453-4057qib7 7425 31 -1 -1 NN cord-005453-4057qib7 7425 32 ) ) -RRB- cord-005453-4057qib7 7425 33 , , , cord-005453-4057qib7 7425 34 PTCy PTCy NNPS cord-005453-4057qib7 7425 35 ( ( -LRB- cord-005453-4057qib7 7425 36 50mg 50mg NNP cord-005453-4057qib7 7425 37 / / SYM cord-005453-4057qib7 7425 38 kg kg NN cord-005453-4057qib7 7425 39 / / SYM cord-005453-4057qib7 7425 40 day day NN cord-005453-4057qib7 7425 41 : : : cord-005453-4057qib7 7425 42 day day NN cord-005453-4057qib7 7425 43 +3,+4 +3,+4 NNP cord-005453-4057qib7 7425 44 ) ) -RRB- cord-005453-4057qib7 7425 45 , , , cord-005453-4057qib7 7425 46 and and CC cord-005453-4057qib7 7425 47 cyclosporine cyclosporine NN cord-005453-4057qib7 7425 48 . . . cord-005453-4057qib7 7426 1 Unmanipulated unmanipulated JJ cord-005453-4057qib7 7426 2 peripheral peripheral JJ cord-005453-4057qib7 7426 3 blood blood NN cord-005453-4057qib7 7426 4 stem stem NN cord-005453-4057qib7 7426 5 cells cell NNS cord-005453-4057qib7 7426 6 were be VBD cord-005453-4057qib7 7426 7 infused infuse VBN cord-005453-4057qib7 7426 8 . . . cord-005453-4057qib7 7427 1 Last last JJ cord-005453-4057qib7 7427 2 followup followup NN cord-005453-4057qib7 7427 3 was be VBD cord-005453-4057qib7 7427 4 November November NNP cord-005453-4057qib7 7427 5 2018 2018 CD cord-005453-4057qib7 7427 6 . . . cord-005453-4057qib7 7428 1 Median median JJ cord-005453-4057qib7 7428 2 follow follow NN cord-005453-4057qib7 7428 3 - - HYPH cord-005453-4057qib7 7428 4 up up NN cord-005453-4057qib7 7428 5 was be VBD cord-005453-4057qib7 7428 6 13 13 CD cord-005453-4057qib7 7428 7 months month NNS cord-005453-4057qib7 7429 1 ( ( -LRB- cord-005453-4057qib7 7429 2 range range NNP cord-005453-4057qib7 7429 3 5 5 CD cord-005453-4057qib7 7429 4 - - SYM cord-005453-4057qib7 7429 5 26 26 CD cord-005453-4057qib7 7429 6 ) ) -RRB- cord-005453-4057qib7 7429 7 . . . cord-005453-4057qib7 7430 1 Median median JJ cord-005453-4057qib7 7430 2 cell cell NN cord-005453-4057qib7 7430 3 dose dose NN cord-005453-4057qib7 7430 4 count count NN cord-005453-4057qib7 7430 5 infused infuse VBN cord-005453-4057qib7 7430 6 was be VBD cord-005453-4057qib7 7430 7 9.83 9.83 CD cord-005453-4057qib7 7430 8 CD34+/Kg CD34+/Kg NNP cord-005453-4057qib7 7430 9 . . . cord-005453-4057qib7 7431 1 We -PRON- PRP cord-005453-4057qib7 7431 2 arbitrarily arbitrarily RB cord-005453-4057qib7 7431 3 divided divide VBD cord-005453-4057qib7 7431 4 the the DT cord-005453-4057qib7 7431 5 cohort cohort NN cord-005453-4057qib7 7431 6 in in IN cord-005453-4057qib7 7431 7 two two CD cord-005453-4057qib7 7431 8 groups group NNS cord-005453-4057qib7 7431 9 with with IN cord-005453-4057qib7 7431 10 CD34 CD34 NNP cord-005453-4057qib7 7431 11 + + CC cord-005453-4057qib7 7431 12 dose dose NN cord-005453-4057qib7 7431 13 of of IN cord-005453-4057qib7 7431 14 > > XX cord-005453-4057qib7 7431 15 8x10 8x10 CD cord-005453-4057qib7 7431 16 ^ ^ SYM cord-005453-4057qib7 7431 17 6 6 CD cord-005453-4057qib7 7431 18 CD34 CD34 NNP cord-005453-4057qib7 7431 19 / / SYM cord-005453-4057qib7 7431 20 Kg Kg NNP cord-005453-4057qib7 7431 21 as as IN cord-005453-4057qib7 7431 22 cut cut VBN cord-005453-4057qib7 7431 23 - - HYPH cord-005453-4057qib7 7431 24 off off RP cord-005453-4057qib7 7431 25 point point NN cord-005453-4057qib7 7431 26 . . . cord-005453-4057qib7 7432 1 Results result NNS cord-005453-4057qib7 7432 2 : : : cord-005453-4057qib7 7433 1 Findings finding NNS cord-005453-4057qib7 7433 2 are be VBP cord-005453-4057qib7 7433 3 summarized summarize VBN cord-005453-4057qib7 7433 4 in in IN cord-005453-4057qib7 7433 5 Figure1 Figure1 NNP cord-005453-4057qib7 7433 6 . . . cord-005453-4057qib7 7434 1 The the DT cord-005453-4057qib7 7434 2 infusion infusion NN cord-005453-4057qib7 7434 3 of of IN cord-005453-4057qib7 7434 4 more more JJR cord-005453-4057qib7 7434 5 than than IN cord-005453-4057qib7 7434 6 8x10 8x10 CD cord-005453-4057qib7 7434 7 ^ ^ SYM cord-005453-4057qib7 7434 8 6 6 CD cord-005453-4057qib7 7434 9 CD34 CD34 NNP cord-005453-4057qib7 7434 10 / / SYM cord-005453-4057qib7 7434 11 Kg Kg NNP cord-005453-4057qib7 7434 12 dose dose NN cord-005453-4057qib7 7434 13 had have VBD cord-005453-4057qib7 7434 14 a a DT cord-005453-4057qib7 7434 15 significant significant JJ cord-005453-4057qib7 7434 16 worse bad JJR cord-005453-4057qib7 7434 17 impact impact NN cord-005453-4057qib7 7434 18 on on IN cord-005453-4057qib7 7434 19 overall overall JJ cord-005453-4057qib7 7434 20 survival survival NN cord-005453-4057qib7 7434 21 ( ( -LRB- cord-005453-4057qib7 7434 22 OS OS NNP cord-005453-4057qib7 7434 23 ) ) -RRB- cord-005453-4057qib7 7434 24 ( ( -LRB- cord-005453-4057qib7 7434 25 P=0.022 P=0.022 NNP cord-005453-4057qib7 7434 26 ) ) -RRB- cord-005453-4057qib7 7434 27 , , , cord-005453-4057qib7 7434 28 relapse relapse NN cord-005453-4057qib7 7434 29 - - HYPH cord-005453-4057qib7 7434 30 free free JJ cord-005453-4057qib7 7434 31 survival survival NN cord-005453-4057qib7 7434 32 ( ( -LRB- cord-005453-4057qib7 7434 33 RFS RFS NNP cord-005453-4057qib7 7434 34 ) ) -RRB- cord-005453-4057qib7 7434 35 ( ( -LRB- cord-005453-4057qib7 7434 36 P=0.042 P=0.042 NNP cord-005453-4057qib7 7434 37 ) ) -RRB- cord-005453-4057qib7 7434 38 and and CC cord-005453-4057qib7 7434 39 cumulative cumulative JJ cord-005453-4057qib7 7434 40 incidence incidence NN cord-005453-4057qib7 7434 41 of of IN cord-005453-4057qib7 7434 42 acute acute JJ cord-005453-4057qib7 7434 43 GVHD GVHD NNP cord-005453-4057qib7 7434 44 ( ( -LRB- cord-005453-4057qib7 7434 45 P=0.000 P=0.000 NNP cord-005453-4057qib7 7434 46 ) ) -RRB- cord-005453-4057qib7 7434 47 . . . cord-005453-4057qib7 7435 1 Chronic chronic JJ cord-005453-4057qib7 7435 2 GVHD GVHD NNP cord-005453-4057qib7 7435 3 could could MD cord-005453-4057qib7 7435 4 not not RB cord-005453-4057qib7 7435 5 be be VB cord-005453-4057qib7 7435 6 compared compare VBN cord-005453-4057qib7 7435 7 between between IN cord-005453-4057qib7 7435 8 the the DT cord-005453-4057qib7 7435 9 two two CD cord-005453-4057qib7 7435 10 cohorts cohort NNS cord-005453-4057qib7 7435 11 due due JJ cord-005453-4057qib7 7435 12 to to IN cord-005453-4057qib7 7435 13 the the DT cord-005453-4057qib7 7435 14 different different JJ cord-005453-4057qib7 7435 15 median median JJ cord-005453-4057qib7 7435 16 follow follow NN cord-005453-4057qib7 7435 17 - - HYPH cord-005453-4057qib7 7435 18 up up NN cord-005453-4057qib7 7435 19 . . . cord-005453-4057qib7 7436 1 Conclusions conclusion NNS cord-005453-4057qib7 7436 2 : : : cord-005453-4057qib7 7437 1 The the DT cord-005453-4057qib7 7437 2 infusion infusion NN cord-005453-4057qib7 7437 3 of of IN cord-005453-4057qib7 7437 4 a a DT cord-005453-4057qib7 7437 5 CD34 CD34 NNP cord-005453-4057qib7 7437 6 + + CC cord-005453-4057qib7 7437 7 cell cell NN cord-005453-4057qib7 7437 8 dose dose NN cord-005453-4057qib7 7437 9 count count NN cord-005453-4057qib7 7437 10 higher high JJR cord-005453-4057qib7 7437 11 than than IN cord-005453-4057qib7 7437 12 8x10 8x10 CD cord-005453-4057qib7 7437 13 ^ ^ SYM cord-005453-4057qib7 7437 14 6 6 CD cord-005453-4057qib7 7437 15 cells cell NNS cord-005453-4057qib7 7437 16 / / SYM cord-005453-4057qib7 7437 17 kg kg NNS cord-005453-4057qib7 7437 18 had have VBD cord-005453-4057qib7 7437 19 a a DT cord-005453-4057qib7 7437 20 significant significant JJ cord-005453-4057qib7 7437 21 adverse adverse JJ cord-005453-4057qib7 7437 22 impact impact NN cord-005453-4057qib7 7437 23 in in IN cord-005453-4057qib7 7437 24 overall overall JJ cord-005453-4057qib7 7437 25 survival survival NN cord-005453-4057qib7 7437 26 and and CC cord-005453-4057qib7 7437 27 grade grade NN cord-005453-4057qib7 7437 28 II II NNP cord-005453-4057qib7 7437 29 - - HYPH cord-005453-4057qib7 7437 30 IV IV NNP cord-005453-4057qib7 7437 31 acute acute JJ cord-005453-4057qib7 7437 32 GVHD GVHD NNP cord-005453-4057qib7 7437 33 in in IN cord-005453-4057qib7 7437 34 the the DT cord-005453-4057qib7 7437 35 setting setting NN cord-005453-4057qib7 7437 36 of of IN cord-005453-4057qib7 7437 37 RIC RIC NNP cord-005453-4057qib7 7437 38 and and CC cord-005453-4057qib7 7437 39 dual dual JJ cord-005453-4057qib7 7437 40 T t NN cord-005453-4057qib7 7437 41 - - HYPH cord-005453-4057qib7 7437 42 lymphocyte lymphocyte NN cord-005453-4057qib7 7437 43 suppression suppression NN cord-005453-4057qib7 7437 44 with with IN cord-005453-4057qib7 7437 45 ATG ATG NNP cord-005453-4057qib7 7437 46 and and CC cord-005453-4057qib7 7437 47 PTCy PTCy NNPS cord-005453-4057qib7 7437 48 for for IN cord-005453-4057qib7 7437 49 haploHSCT haploHSCT NNP cord-005453-4057qib7 7437 50 . . . cord-005453-4057qib7 7438 1 Disclosure disclosure NN cord-005453-4057qib7 7438 2 : : : cord-005453-4057qib7 7438 3 Nothing nothing NN cord-005453-4057qib7 7438 4 to to TO cord-005453-4057qib7 7438 5 declare declare VB cord-005453-4057qib7 7438 6 P335 p335 CD cord-005453-4057qib7 7438 7 Long long JJ cord-005453-4057qib7 7438 8 - - HYPH cord-005453-4057qib7 7438 9 term term NN cord-005453-4057qib7 7438 10 thymic thymic JJ cord-005453-4057qib7 7438 11 activity activity NN cord-005453-4057qib7 7438 12 and and CC cord-005453-4057qib7 7438 13 immune immune JJ cord-005453-4057qib7 7438 14 - - HYPH cord-005453-4057qib7 7438 15 reconstitution reconstitution NN cord-005453-4057qib7 7438 16 after after IN cord-005453-4057qib7 7438 17 haplo haplo NN cord-005453-4057qib7 7438 18 - - HYPH cord-005453-4057qib7 7438 19 identical identical JJ cord-005453-4057qib7 7438 20 allografting allografting NN cord-005453-4057qib7 7438 21 with with IN cord-005453-4057qib7 7438 22 post post JJ cord-005453-4057qib7 7438 23 - - JJ cord-005453-4057qib7 7438 24 transplant transplant NN cord-005453-4057qib7 7438 25 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 7438 26 Background background NN cord-005453-4057qib7 7438 27 : : : cord-005453-4057qib7 7439 1 The the DT cord-005453-4057qib7 7439 2 use use NN cord-005453-4057qib7 7439 3 of of IN cord-005453-4057qib7 7439 4 post post JJ cord-005453-4057qib7 7439 5 - - JJ cord-005453-4057qib7 7439 6 transplant transplant NN cord-005453-4057qib7 7439 7 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 7439 8 ( ( -LRB- cord-005453-4057qib7 7439 9 PTCY PTCY NNP cord-005453-4057qib7 7439 10 ) ) -RRB- cord-005453-4057qib7 7439 11 has have VBZ cord-005453-4057qib7 7439 12 expanded expand VBN cord-005453-4057qib7 7439 13 the the DT cord-005453-4057qib7 7439 14 application application NN cord-005453-4057qib7 7439 15 of of IN cord-005453-4057qib7 7439 16 T T NNP cord-005453-4057qib7 7439 17 repleted replete VBD cord-005453-4057qib7 7439 18 haploidentical haploidentical JJ cord-005453-4057qib7 7439 19 stem stem NN cord-005453-4057qib7 7439 20 cell cell NN cord-005453-4057qib7 7439 21 transplantation transplantation NN cord-005453-4057qib7 7439 22 ( ( -LRB- cord-005453-4057qib7 7439 23 haplo haplo NNP cord-005453-4057qib7 7439 24 - - HYPH cord-005453-4057qib7 7439 25 HSCT HSCT NNP cord-005453-4057qib7 7439 26 ) ) -RRB- cord-005453-4057qib7 7439 27 . . . cord-005453-4057qib7 7440 1 In in IN cord-005453-4057qib7 7440 2 this this DT cord-005453-4057qib7 7440 3 setting setting NN cord-005453-4057qib7 7440 4 , , , cord-005453-4057qib7 7440 5 to to TO cord-005453-4057qib7 7440 6 investigate investigate VB cord-005453-4057qib7 7440 7 thymus thymus NN cord-005453-4057qib7 7440 8 role role NN cord-005453-4057qib7 7440 9 in in IN cord-005453-4057qib7 7440 10 longterm longterm JJ cord-005453-4057qib7 7440 11 clinical clinical JJ cord-005453-4057qib7 7440 12 outcomes outcome NNS cord-005453-4057qib7 7440 13 , , , cord-005453-4057qib7 7440 14 evaluation evaluation NN cord-005453-4057qib7 7440 15 of of IN cord-005453-4057qib7 7440 16 immune immune JJ cord-005453-4057qib7 7440 17 reconstitution reconstitution NN cord-005453-4057qib7 7440 18 kinetics kinetics NN cord-005453-4057qib7 7440 19 was be VBD cord-005453-4057qib7 7440 20 performed perform VBN cord-005453-4057qib7 7440 21 . . . cord-005453-4057qib7 7441 1 Methods method NNS cord-005453-4057qib7 7441 2 : : : cord-005453-4057qib7 7441 3 Twenty twenty CD cord-005453-4057qib7 7441 4 - - HYPH cord-005453-4057qib7 7441 5 nine nine CD cord-005453-4057qib7 7441 6 patients patient NNS cord-005453-4057qib7 7441 7 ( ( -LRB- cord-005453-4057qib7 7441 8 median median JJ cord-005453-4057qib7 7441 9 age age NN cord-005453-4057qib7 7441 10 53 53 CD cord-005453-4057qib7 7441 11 ) ) -RRB- cord-005453-4057qib7 7441 12 were be VBD cord-005453-4057qib7 7441 13 enrolled enrol VBN cord-005453-4057qib7 7441 14 . . . cord-005453-4057qib7 7442 1 Blood blood NN cord-005453-4057qib7 7442 2 samples sample NNS cord-005453-4057qib7 7442 3 were be VBD cord-005453-4057qib7 7442 4 collected collect VBN cord-005453-4057qib7 7442 5 before before IN cord-005453-4057qib7 7442 6 conditioning conditioning NN cord-005453-4057qib7 7442 7 and and CC cord-005453-4057qib7 7442 8 at at IN cord-005453-4057qib7 7442 9 1 1 CD cord-005453-4057qib7 7442 10 , , , cord-005453-4057qib7 7442 11 3 3 CD cord-005453-4057qib7 7442 12 , , , cord-005453-4057qib7 7442 13 6 6 CD cord-005453-4057qib7 7442 14 , , , cord-005453-4057qib7 7442 15 12 12 CD cord-005453-4057qib7 7442 16 , , , cord-005453-4057qib7 7442 17 18 18 CD cord-005453-4057qib7 7442 18 , , , cord-005453-4057qib7 7442 19 24 24 CD cord-005453-4057qib7 7442 20 months month NNS cord-005453-4057qib7 7442 21 after after IN cord-005453-4057qib7 7442 22 Haplo Haplo NNP cord-005453-4057qib7 7442 23 - - HYPH cord-005453-4057qib7 7442 24 HSCT HSCT NNP cord-005453-4057qib7 7442 25 . . . cord-005453-4057qib7 7443 1 Analyses analysis NNS cord-005453-4057qib7 7443 2 of of IN cord-005453-4057qib7 7443 3 CD4 CD4 NNP cord-005453-4057qib7 7443 4 and and CC cord-005453-4057qib7 7443 5 CD8 CD8 NNP cord-005453-4057qib7 7443 6 T T NNP cord-005453-4057qib7 7443 7 - - HYPH cord-005453-4057qib7 7443 8 cell cell NN cord-005453-4057qib7 7443 9 subsets subset NNS cord-005453-4057qib7 7443 10 by by IN cord-005453-4057qib7 7443 11 flow flow NN cord-005453-4057qib7 7443 12 - - HYPH cord-005453-4057qib7 7443 13 cytometry cytometry NN cord-005453-4057qib7 7443 14 were be VBD cord-005453-4057qib7 7443 15 correlated correlate VBN cord-005453-4057qib7 7443 16 by by IN cord-005453-4057qib7 7443 17 generalized generalized JJ cord-005453-4057qib7 7443 18 linear linear JJ cord-005453-4057qib7 7443 19 models model NNS cord-005453-4057qib7 7443 20 with with IN cord-005453-4057qib7 7443 21 Real real JJ cord-005453-4057qib7 7443 22 - - HYPH cord-005453-4057qib7 7443 23 Time time NN cord-005453-4057qib7 7443 24 PCR PCR NNP cord-005453-4057qib7 7443 25 ( ( -LRB- cord-005453-4057qib7 7443 26 RT RT NNP cord-005453-4057qib7 7443 27 - - HYPH cord-005453-4057qib7 7443 28 PCR PCR NNP cord-005453-4057qib7 7443 29 ) ) -RRB- cord-005453-4057qib7 7443 30 quantification quantification NN cord-005453-4057qib7 7443 31 of of IN cord-005453-4057qib7 7443 32 signal signal NN cord-005453-4057qib7 7443 33 joint joint JJ cord-005453-4057qib7 7443 34 T t NN cord-005453-4057qib7 7443 35 - - HYPH cord-005453-4057qib7 7443 36 cell cell NN cord-005453-4057qib7 7443 37 receptor receptor NN cord-005453-4057qib7 7443 38 excision excision NN cord-005453-4057qib7 7443 39 DNA dna NN cord-005453-4057qib7 7443 40 circles circle NNS cord-005453-4057qib7 7443 41 ( ( -LRB- cord-005453-4057qib7 7443 42 sjTRECs sjtrecs NN cord-005453-4057qib7 7443 43 ) ) -RRB- cord-005453-4057qib7 7443 44 , , , cord-005453-4057qib7 7443 45 specific specific JJ cord-005453-4057qib7 7443 46 marker marker NN cord-005453-4057qib7 7443 47 of of IN cord-005453-4057qib7 7443 48 naive naive JJ cord-005453-4057qib7 7443 49 T T NNP cord-005453-4057qib7 7443 50 - - HYPH cord-005453-4057qib7 7443 51 cells cell NNS cord-005453-4057qib7 7443 52 thymopoiesis thymopoiesis NN cord-005453-4057qib7 7443 53 . . . cord-005453-4057qib7 7444 1 A a LS cord-005453-4057qib7 7444 2 ) ) -RRB- cord-005453-4057qib7 7444 3 Naive naive JJ cord-005453-4057qib7 7444 4 ; ; : cord-005453-4057qib7 7444 5 b b LS cord-005453-4057qib7 7444 6 ) ) -RRB- cord-005453-4057qib7 7444 7 central central JJ cord-005453-4057qib7 7444 8 ; ; : cord-005453-4057qib7 7444 9 c c NN cord-005453-4057qib7 7444 10 ) ) -RRB- cord-005453-4057qib7 7444 11 memory memory NN cord-005453-4057qib7 7444 12 ; ; : cord-005453-4057qib7 7444 13 and and CC cord-005453-4057qib7 7444 14 d d LS cord-005453-4057qib7 7444 15 ) ) -RRB- cord-005453-4057qib7 7445 1 revertant revertant NNP cord-005453-4057qib7 7445 2 CD4 CD4 NNP cord-005453-4057qib7 7445 3 and and CC cord-005453-4057qib7 7445 4 CD8 CD8 NNP cord-005453-4057qib7 7445 5 T T NNP cord-005453-4057qib7 7445 6 - - HYPH cord-005453-4057qib7 7445 7 cells cell NNS cord-005453-4057qib7 7445 8 were be VBD cord-005453-4057qib7 7445 9 defined define VBN cord-005453-4057qib7 7445 10 as as IN cord-005453-4057qib7 7445 11 follows follow VBZ cord-005453-4057qib7 7445 12 : : : cord-005453-4057qib7 7445 13 a a LS cord-005453-4057qib7 7445 14 ) ) -RRB- cord-005453-4057qib7 7445 15 CD45RA+CD62L+ CD45RA+CD62L+ NNS cord-005453-4057qib7 7445 16 ; ; : cord-005453-4057qib7 7446 1 b b LS cord-005453-4057qib7 7446 2 ) ) -RRB- cord-005453-4057qib7 7446 3 CD45RO cd45ro VB cord-005453-4057qib7 7446 4 + + SYM cord-005453-4057qib7 7446 5 CD62L+ CD62L+ NNS cord-005453-4057qib7 7446 6 ; ; : cord-005453-4057qib7 7446 7 c c LS cord-005453-4057qib7 7446 8 ) ) -RRB- cord-005453-4057qib7 7446 9 CD45RO+CD27- CD45RO+CD27- NNP cord-005453-4057qib7 7446 10 ; ; : cord-005453-4057qib7 7446 11 and and CC cord-005453-4057qib7 7446 12 d d LS cord-005453-4057qib7 7446 13 ) ) -RRB- cord-005453-4057qib7 7446 14 CD45RA+/45RO cd45ra+/45ro NN cord-005453-4057qib7 7446 15 + + CC cord-005453-4057qib7 7446 16 , , , cord-005453-4057qib7 7446 17 respectively respectively RB cord-005453-4057qib7 7446 18 . . . cord-005453-4057qib7 7447 1 SjTRECs SjTRECs NNP cord-005453-4057qib7 7447 2 RT.PCR RT.PCR NNP cord-005453-4057qib7 7447 3 was be VBD cord-005453-4057qib7 7447 4 performed perform VBN cord-005453-4057qib7 7447 5 on on IN cord-005453-4057qib7 7447 6 genomic genomic JJ cord-005453-4057qib7 7447 7 DNA dna NN cord-005453-4057qib7 7447 8 ( ( -LRB- cord-005453-4057qib7 7447 9 100 100 CD cord-005453-4057qib7 7447 10 ng ng NN cord-005453-4057qib7 7447 11 ) ) -RRB- cord-005453-4057qib7 7447 12 extracted extract VBN cord-005453-4057qib7 7447 13 from from IN cord-005453-4057qib7 7447 14 sorted sort VBN cord-005453-4057qib7 7447 15 CD4 CD4 NNP cord-005453-4057qib7 7447 16 and and CC cord-005453-4057qib7 7447 17 CD8 CD8 NNP cord-005453-4057qib7 7447 18 T T NNP cord-005453-4057qib7 7447 19 - - HYPH cord-005453-4057qib7 7447 20 cells cell NNS cord-005453-4057qib7 7447 21 . . . cord-005453-4057qib7 7448 1 Results result NNS cord-005453-4057qib7 7448 2 : : : cord-005453-4057qib7 7449 1 A a DT cord-005453-4057qib7 7449 2 gradual gradual JJ cord-005453-4057qib7 7449 3 increase increase NN cord-005453-4057qib7 7449 4 in in IN cord-005453-4057qib7 7449 5 absolute absolute JJ cord-005453-4057qib7 7449 6 numbers number NNS cord-005453-4057qib7 7449 7 of of IN cord-005453-4057qib7 7449 8 all all DT cord-005453-4057qib7 7449 9 CD4 CD4 NNP cord-005453-4057qib7 7449 10 and and CC cord-005453-4057qib7 7449 11 CD8 CD8 NNP cord-005453-4057qib7 7449 12 T T NNP cord-005453-4057qib7 7449 13 cell cell NN cord-005453-4057qib7 7449 14 subsets subset NNS cord-005453-4057qib7 7449 15 and and CC cord-005453-4057qib7 7449 16 of of IN cord-005453-4057qib7 7449 17 sjTRECs sjtrecs NN cord-005453-4057qib7 7449 18 copies copy NNS cord-005453-4057qib7 7449 19 from from IN cord-005453-4057qib7 7449 20 the the DT cord-005453-4057qib7 7449 21 first first JJ cord-005453-4057qib7 7449 22 month month NN cord-005453-4057qib7 7449 23 up up IN cord-005453-4057qib7 7449 24 to to TO cord-005453-4057qib7 7449 25 2 2 CD cord-005453-4057qib7 7449 26 years year NNS cord-005453-4057qib7 7449 27 post post JJ cord-005453-4057qib7 7449 28 - - NN cord-005453-4057qib7 7449 29 transplant transplant NN cord-005453-4057qib7 7449 30 was be VBD cord-005453-4057qib7 7449 31 observed observe VBN cord-005453-4057qib7 7449 32 ( ( -LRB- cord-005453-4057qib7 7449 33 Figure figure NN cord-005453-4057qib7 7449 34 1 1 CD cord-005453-4057qib7 7449 35 ) ) -RRB- cord-005453-4057qib7 7449 36 . . . cord-005453-4057qib7 7450 1 However however RB cord-005453-4057qib7 7450 2 , , , cord-005453-4057qib7 7450 3 at at IN cord-005453-4057qib7 7450 4 2 2 CD cord-005453-4057qib7 7450 5 years year NNS cord-005453-4057qib7 7450 6 , , , cord-005453-4057qib7 7450 7 CD4 CD4 NNP cord-005453-4057qib7 7450 8 and and CC cord-005453-4057qib7 7450 9 CD8 CD8 NNP cord-005453-4057qib7 7450 10 T T NNP cord-005453-4057qib7 7450 11 - - HYPH cord-005453-4057qib7 7450 12 cell cell NN cord-005453-4057qib7 7450 13 levels level NNS cord-005453-4057qib7 7450 14 and and CC cord-005453-4057qib7 7450 15 sjTRECs sjtrecs NN cord-005453-4057qib7 7450 16 levels level NNS cord-005453-4057qib7 7450 17 were be VBD cord-005453-4057qib7 7450 18 lower low JJR cord-005453-4057qib7 7450 19 than than IN cord-005453-4057qib7 7450 20 those those DT cord-005453-4057qib7 7450 21 observed observe VBN cord-005453-4057qib7 7450 22 in in IN cord-005453-4057qib7 7450 23 healthy healthy JJ cord-005453-4057qib7 7450 24 donors donor NNS cord-005453-4057qib7 7450 25 . . . cord-005453-4057qib7 7451 1 sjTRECs sjTRECs NNP cord-005453-4057qib7 7451 2 kinetics kinetics NNP cord-005453-4057qib7 7451 3 was be VBD cord-005453-4057qib7 7451 4 associated associate VBN cord-005453-4057qib7 7451 5 with with IN cord-005453-4057qib7 7451 6 the the DT cord-005453-4057qib7 7451 7 increase increase NN cord-005453-4057qib7 7451 8 in in IN cord-005453-4057qib7 7451 9 CD4 CD4 NNP cord-005453-4057qib7 7451 10 naive naive JJ cord-005453-4057qib7 7451 11 T T NNP cord-005453-4057qib7 7451 12 - - HYPH cord-005453-4057qib7 7451 13 cells cell NNS cord-005453-4057qib7 7451 14 ( ( -LRB- cord-005453-4057qib7 7451 15 overall overall RB cord-005453-4057qib7 7451 16 , , , cord-005453-4057qib7 7451 17 p p NN cord-005453-4057qib7 7451 18 < < XX cord-005453-4057qib7 7451 19 0.002 0.002 CD cord-005453-4057qib7 7451 20 ) ) -RRB- cord-005453-4057qib7 7451 21 . . . cord-005453-4057qib7 7452 1 This this DT cord-005453-4057qib7 7452 2 correlation correlation NN cord-005453-4057qib7 7452 3 suggests suggest VBZ cord-005453-4057qib7 7452 4 that that IN cord-005453-4057qib7 7452 5 most most JJS cord-005453-4057qib7 7452 6 of of IN cord-005453-4057qib7 7452 7 CD4 CD4 NNP cord-005453-4057qib7 7452 8 naive naive JJ cord-005453-4057qib7 7452 9 T T NNP cord-005453-4057qib7 7452 10 - - HYPH cord-005453-4057qib7 7452 11 cells cell NNS cord-005453-4057qib7 7452 12 derives derive VBZ cord-005453-4057qib7 7452 13 from from IN cord-005453-4057qib7 7452 14 thymic thymic JJ cord-005453-4057qib7 7452 15 re re NN cord-005453-4057qib7 7452 16 - - NN cord-005453-4057qib7 7452 17 education education NN cord-005453-4057qib7 7452 18 of of IN cord-005453-4057qib7 7452 19 donor donor NN cord-005453-4057qib7 7452 20 precursor precursor NN cord-005453-4057qib7 7452 21 stem stem NN cord-005453-4057qib7 7452 22 cells cell NNS cord-005453-4057qib7 7452 23 , , , cord-005453-4057qib7 7452 24 whereas whereas IN cord-005453-4057qib7 7452 25 CD8 CD8 NNP cord-005453-4057qib7 7452 26 naive naive JJ cord-005453-4057qib7 7452 27 T T NNP cord-005453-4057qib7 7452 28 - - HYPH cord-005453-4057qib7 7452 29 cells cell NNS cord-005453-4057qib7 7452 30 undergo undergo VBP cord-005453-4057qib7 7452 31 peripheral peripheral JJ cord-005453-4057qib7 7452 32 expansion expansion NN cord-005453-4057qib7 7452 33 after after IN cord-005453-4057qib7 7452 34 thymic thymic JJ cord-005453-4057qib7 7452 35 production production NN cord-005453-4057qib7 7452 36 . . . cord-005453-4057qib7 7453 1 Furthermore furthermore RB cord-005453-4057qib7 7453 2 , , , cord-005453-4057qib7 7453 3 an an DT cord-005453-4057qib7 7453 4 increase increase NN cord-005453-4057qib7 7453 5 in in IN cord-005453-4057qib7 7453 6 CD4 CD4 NNP cord-005453-4057qib7 7453 7 revertant revertant NNP cord-005453-4057qib7 7453 8 memory memory NN cord-005453-4057qib7 7453 9 T T NNP cord-005453-4057qib7 7453 10 - - HYPH cord-005453-4057qib7 7453 11 cells cell NNS cord-005453-4057qib7 7453 12 was be VBD cord-005453-4057qib7 7453 13 also also RB cord-005453-4057qib7 7453 14 significantly significantly RB cord-005453-4057qib7 7453 15 correlated correlate VBN cord-005453-4057qib7 7453 16 with with IN cord-005453-4057qib7 7453 17 sjTRECs sjtrecs NN cord-005453-4057qib7 7453 18 kinetic kinetic NNP cord-005453-4057qib7 7453 19 ( ( -LRB- cord-005453-4057qib7 7453 20 p p NN cord-005453-4057qib7 7453 21 0,041 0,041 CD cord-005453-4057qib7 7453 22 ) ) -RRB- cord-005453-4057qib7 7453 23 . . . cord-005453-4057qib7 7454 1 Central central JJ cord-005453-4057qib7 7454 2 and and CC cord-005453-4057qib7 7454 3 effector effector JJ cord-005453-4057qib7 7454 4 memory memory NN cord-005453-4057qib7 7454 5 T t NN cord-005453-4057qib7 7454 6 - - HYPH cord-005453-4057qib7 7454 7 cells cell NNS cord-005453-4057qib7 7454 8 showed show VBD cord-005453-4057qib7 7454 9 a a DT cord-005453-4057qib7 7454 10 faster fast RBR cord-005453-4057qib7 7454 11 thymic thymic JJ cord-005453-4057qib7 7454 12 - - HYPH cord-005453-4057qib7 7454 13 independent independent JJ cord-005453-4057qib7 7454 14 expansion expansion NN cord-005453-4057qib7 7454 15 in in IN cord-005453-4057qib7 7454 16 both both CC cord-005453-4057qib7 7454 17 CD4 CD4 NNP cord-005453-4057qib7 7454 18 and and CC cord-005453-4057qib7 7454 19 CD8 CD8 NNP cord-005453-4057qib7 7454 20 Tcells Tcells NNP cord-005453-4057qib7 7454 21 . . . cord-005453-4057qib7 7455 1 Interestingly interestingly RB cord-005453-4057qib7 7455 2 , , , cord-005453-4057qib7 7455 3 sjTRECs sjtrecs NN cord-005453-4057qib7 7455 4 levels level NNS cord-005453-4057qib7 7455 5 and and CC cord-005453-4057qib7 7455 6 thymic thymic JJ cord-005453-4057qib7 7455 7 dependent dependent JJ cord-005453-4057qib7 7455 8 immune immune NN cord-005453-4057qib7 7455 9 - - HYPH cord-005453-4057qib7 7455 10 reconstitution reconstitution NN cord-005453-4057qib7 7455 11 were be VBD cord-005453-4057qib7 7455 12 higher high JJR cord-005453-4057qib7 7455 13 in in IN cord-005453-4057qib7 7455 14 a a DT cord-005453-4057qib7 7455 15 cohort cohort NN cord-005453-4057qib7 7455 16 of of IN cord-005453-4057qib7 7455 17 63 63 CD cord-005453-4057qib7 7455 18 patients patient NNS cord-005453-4057qib7 7455 19 undergoing undergo VBG cord-005453-4057qib7 7455 20 HSCT HSCT NNP cord-005453-4057qib7 7455 21 from from IN cord-005453-4057qib7 7455 22 HLA HLA NNP cord-005453-4057qib7 7455 23 identical identical JJ cord-005453-4057qib7 7455 24 donors donor NNS cord-005453-4057qib7 7455 25 ( ( -LRB- cord-005453-4057qib7 7455 26 manuscript manuscript NN cord-005453-4057qib7 7455 27 in in IN cord-005453-4057qib7 7455 28 preparation preparation NN cord-005453-4057qib7 7455 29 ) ) -RRB- cord-005453-4057qib7 7455 30 . . . cord-005453-4057qib7 7456 1 Clinical clinical JJ cord-005453-4057qib7 7456 2 outcomes outcome NNS cord-005453-4057qib7 7456 3 and and CC cord-005453-4057qib7 7456 4 thymic thymic JJ cord-005453-4057qib7 7456 5 function function NN cord-005453-4057qib7 7456 6 were be VBD cord-005453-4057qib7 7456 7 correlated correlate VBN cord-005453-4057qib7 7456 8 starting start VBG cord-005453-4057qib7 7456 9 at at IN cord-005453-4057qib7 7456 10 6 6 CD cord-005453-4057qib7 7456 11 months month NNS cord-005453-4057qib7 7456 12 after after IN cord-005453-4057qib7 7456 13 HSCT HSCT NNP cord-005453-4057qib7 7456 14 . . . cord-005453-4057qib7 7457 1 Lower low JJR cord-005453-4057qib7 7457 2 thymic thymic JJ cord-005453-4057qib7 7457 3 output output NN cord-005453-4057qib7 7457 4 was be VBD cord-005453-4057qib7 7457 5 significantly significantly RB cord-005453-4057qib7 7457 6 associated associate VBN cord-005453-4057qib7 7457 7 by by IN cord-005453-4057qib7 7457 8 multivariate multivariate JJ cord-005453-4057qib7 7457 9 analysis analysis NN cord-005453-4057qib7 7457 10 with with IN cord-005453-4057qib7 7457 11 low low JJ cord-005453-4057qib7 7457 12 pre pre JJ cord-005453-4057qib7 7457 13 - - JJ cord-005453-4057qib7 7457 14 transplant transplant JJ cord-005453-4057qib7 7457 15 TRECs trec NNS cord-005453-4057qib7 7457 16 values value NNS cord-005453-4057qib7 7457 17 ( ( -LRB- cord-005453-4057qib7 7457 18 p p NN cord-005453-4057qib7 7457 19 0,002 0,002 CD cord-005453-4057qib7 7457 20 and and CC cord-005453-4057qib7 7457 21 p p NN cord-005453-4057qib7 7457 22 < < XX cord-005453-4057qib7 7457 23 0,001 0,001 CD cord-005453-4057qib7 7457 24 in in IN cord-005453-4057qib7 7457 25 CD4 CD4 NNP cord-005453-4057qib7 7457 26 and and CC cord-005453-4057qib7 7457 27 CD8 CD8 NNP cord-005453-4057qib7 7457 28 , , , cord-005453-4057qib7 7457 29 respectively respectively RB cord-005453-4057qib7 7457 30 ) ) -RRB- cord-005453-4057qib7 7457 31 , , , cord-005453-4057qib7 7457 32 moderate moderate JJ cord-005453-4057qib7 7457 33 - - HYPH cord-005453-4057qib7 7457 34 severe severe JJ cord-005453-4057qib7 7457 35 chronic chronic JJ cord-005453-4057qib7 7457 36 graft graft NN cord-005453-4057qib7 7457 37 - - HYPH cord-005453-4057qib7 7457 38 versus versus IN cord-005453-4057qib7 7457 39 - - HYPH cord-005453-4057qib7 7457 40 host host NN cord-005453-4057qib7 7457 41 disease disease NN cord-005453-4057qib7 7457 42 ( ( -LRB- cord-005453-4057qib7 7457 43 GVHD GVHD NNP cord-005453-4057qib7 7457 44 ; ; . cord-005453-4057qib7 7458 1 p p LS cord-005453-4057qib7 7458 2 < < XX cord-005453-4057qib7 7458 3 0,001 0,001 CD cord-005453-4057qib7 7458 4 in in IN cord-005453-4057qib7 7458 5 CD8 CD8 NNP cord-005453-4057qib7 7458 6 ) ) -RRB- cord-005453-4057qib7 7458 7 , , , cord-005453-4057qib7 7458 8 and and CC cord-005453-4057qib7 7458 9 age age NN cord-005453-4057qib7 7458 10 ( ( -LRB- cord-005453-4057qib7 7458 11 ≥50 ≥50 NNP cord-005453-4057qib7 7458 12 years year NNS cord-005453-4057qib7 7458 13 , , , cord-005453-4057qib7 7458 14 p p NN cord-005453-4057qib7 7458 15 0,006 0,006 CD cord-005453-4057qib7 7458 16 in in IN cord-005453-4057qib7 7458 17 CD8 CD8 NNP cord-005453-4057qib7 7458 18 ) ) -RRB- cord-005453-4057qib7 7458 19 . . . cord-005453-4057qib7 7459 1 Conclusions conclusion NNS cord-005453-4057qib7 7459 2 : : : cord-005453-4057qib7 7460 1 The the DT cord-005453-4057qib7 7460 2 thymus thymus NN cord-005453-4057qib7 7460 3 , , , cord-005453-4057qib7 7460 4 despite despite IN cord-005453-4057qib7 7460 5 age age NN cord-005453-4057qib7 7460 6 - - HYPH cord-005453-4057qib7 7460 7 dependent dependent JJ cord-005453-4057qib7 7460 8 involution involution NN cord-005453-4057qib7 7460 9 , , , cord-005453-4057qib7 7460 10 substantially substantially RB cord-005453-4057qib7 7460 11 contributes contribute VBZ cord-005453-4057qib7 7460 12 to to IN cord-005453-4057qib7 7460 13 T t NN cord-005453-4057qib7 7460 14 - - HYPH cord-005453-4057qib7 7460 15 cell cell NN cord-005453-4057qib7 7460 16 reconstitution reconstitution NN cord-005453-4057qib7 7460 17 after after IN cord-005453-4057qib7 7460 18 haplo haplo NNP cord-005453-4057qib7 7460 19 - - HYPH cord-005453-4057qib7 7460 20 HSCT HSCT NNP cord-005453-4057qib7 7460 21 . . . cord-005453-4057qib7 7461 1 Chronic chronic JJ cord-005453-4057qib7 7461 2 GVHD GVHD NNP cord-005453-4057qib7 7461 3 and and CC cord-005453-4057qib7 7461 4 older old JJR cord-005453-4057qib7 7461 5 age age NN cord-005453-4057qib7 7461 6 were be VBD cord-005453-4057qib7 7461 7 significantly significantly RB cord-005453-4057qib7 7461 8 correlated correlate VBN cord-005453-4057qib7 7461 9 with with IN cord-005453-4057qib7 7461 10 reduced reduced JJ cord-005453-4057qib7 7461 11 thymic thymic JJ cord-005453-4057qib7 7461 12 function function NN cord-005453-4057qib7 7461 13 . . . cord-005453-4057qib7 7462 1 Overall overall RB cord-005453-4057qib7 7462 2 , , , cord-005453-4057qib7 7462 3 lower low JJR cord-005453-4057qib7 7462 4 production production NN cord-005453-4057qib7 7462 5 of of IN cord-005453-4057qib7 7462 6 sjTRECs sjtrecs NN cord-005453-4057qib7 7462 7 after after IN cord-005453-4057qib7 7462 8 haplo haplo NNP cord-005453-4057qib7 7462 9 - - HYPH cord-005453-4057qib7 7462 10 HSCT HSCT NNP cord-005453-4057qib7 7462 11 as as IN cord-005453-4057qib7 7462 12 compared compare VBN cord-005453-4057qib7 7462 13 after after IN cord-005453-4057qib7 7462 14 HLA HLA NNP cord-005453-4057qib7 7462 15 identical identical JJ cord-005453-4057qib7 7462 16 sibling sibling NN cord-005453-4057qib7 7462 17 HSCT HSCT NNP cord-005453-4057qib7 7462 18 may may MD cord-005453-4057qib7 7462 19 partly partly RB cord-005453-4057qib7 7462 20 be be VB cord-005453-4057qib7 7462 21 due due JJ cord-005453-4057qib7 7462 22 to to IN cord-005453-4057qib7 7462 23 a a DT cord-005453-4057qib7 7462 24 higher high JJR cord-005453-4057qib7 7462 25 degree degree NN cord-005453-4057qib7 7462 26 of of IN cord-005453-4057qib7 7462 27 " " `` cord-005453-4057qib7 7462 28 mismatching mismatching NN cord-005453-4057qib7 7462 29 " " '' cord-005453-4057qib7 7462 30 of of IN cord-005453-4057qib7 7462 31 MHC MHC NNP cord-005453-4057qib7 7462 32 molecules molecule NNS cord-005453-4057qib7 7462 33 during during IN cord-005453-4057qib7 7462 34 thymic thymic JJ cord-005453-4057qib7 7462 35 re re NN cord-005453-4057qib7 7462 36 - - NN cord-005453-4057qib7 7462 37 education education NN cord-005453-4057qib7 7462 38 . . . cord-005453-4057qib7 7463 1 [ [ -LRB- cord-005453-4057qib7 7463 2 [ [ -LRB- cord-005453-4057qib7 7463 3 P335 p335 CD cord-005453-4057qib7 7463 4 Image image NN cord-005453-4057qib7 7463 5 ] ] -RRB- cord-005453-4057qib7 7463 6 1 1 CD cord-005453-4057qib7 7463 7 . . . cord-005453-4057qib7 7464 1 Figure figure NN cord-005453-4057qib7 7464 2 1 1 CD cord-005453-4057qib7 7464 3 ] ] -RRB- cord-005453-4057qib7 7465 1 Background background NN cord-005453-4057qib7 7465 2 : : : cord-005453-4057qib7 7466 1 The the DT cord-005453-4057qib7 7466 2 use use NN cord-005453-4057qib7 7466 3 of of IN cord-005453-4057qib7 7466 4 Allogenic Allogenic NNP cord-005453-4057qib7 7466 5 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 7466 6 Stem Stem NNP cord-005453-4057qib7 7466 7 Cell Cell NNP cord-005453-4057qib7 7466 8 Transplantation transplantation NN cord-005453-4057qib7 7466 9 ( ( -LRB- cord-005453-4057qib7 7466 10 HSCT HSCT NNP cord-005453-4057qib7 7466 11 ) ) -RRB- cord-005453-4057qib7 7466 12 in in IN cord-005453-4057qib7 7466 13 the the DT cord-005453-4057qib7 7466 14 treatment treatment NN cord-005453-4057qib7 7466 15 of of IN cord-005453-4057qib7 7466 16 Adolescents Adolescents NNPS cord-005453-4057qib7 7466 17 and and CC cord-005453-4057qib7 7466 18 Young Young NNP cord-005453-4057qib7 7466 19 Adults Adults NNPS cord-005453-4057qib7 7466 20 ( ( -LRB- cord-005453-4057qib7 7466 21 AYA AYA NNP cord-005453-4057qib7 7466 22 ) ) -RRB- cord-005453-4057qib7 7466 23 with with IN cord-005453-4057qib7 7466 24 Philadelphia Philadelphia NNP cord-005453-4057qib7 7466 25 negative negative JJ cord-005453-4057qib7 7466 26 ALL all DT cord-005453-4057qib7 7466 27 is be VBZ cord-005453-4057qib7 7466 28 decreasing decrease VBG cord-005453-4057qib7 7466 29 with with IN cord-005453-4057qib7 7466 30 the the DT cord-005453-4057qib7 7466 31 adoption adoption NN cord-005453-4057qib7 7466 32 of of IN cord-005453-4057qib7 7466 33 pediatric pediatric JJ cord-005453-4057qib7 7466 34 inspired inspire VBN cord-005453-4057qib7 7466 35 protocols protocol NNS cord-005453-4057qib7 7466 36 to to TO cord-005453-4057qib7 7466 37 treat treat VB cord-005453-4057qib7 7466 38 this this DT cord-005453-4057qib7 7466 39 age age NN cord-005453-4057qib7 7466 40 group group NN cord-005453-4057qib7 7466 41 and and CC cord-005453-4057qib7 7466 42 the the DT cord-005453-4057qib7 7466 43 incorporation incorporation NN cord-005453-4057qib7 7466 44 of of IN cord-005453-4057qib7 7466 45 minimal minimal JJ cord-005453-4057qib7 7466 46 residual residual JJ cord-005453-4057qib7 7466 47 disease disease NN cord-005453-4057qib7 7466 48 assessment assessment NN cord-005453-4057qib7 7466 49 in in IN cord-005453-4057qib7 7466 50 the the DT cord-005453-4057qib7 7466 51 routine routine JJ cord-005453-4057qib7 7466 52 care care NN cord-005453-4057qib7 7466 53 of of IN cord-005453-4057qib7 7466 54 ALL all DT cord-005453-4057qib7 7466 55 patients patient NNS cord-005453-4057qib7 7466 56 . . . cord-005453-4057qib7 7467 1 Previously previously RB cord-005453-4057qib7 7467 2 , , , cord-005453-4057qib7 7467 3 its -PRON- PRP$ cord-005453-4057qib7 7467 4 use use NN cord-005453-4057qib7 7467 5 was be VBD cord-005453-4057qib7 7467 6 defined define VBN cord-005453-4057qib7 7467 7 mainly mainly RB cord-005453-4057qib7 7467 8 by by IN cord-005453-4057qib7 7467 9 disease disease NN cord-005453-4057qib7 7467 10 risk risk NN cord-005453-4057qib7 7467 11 features feature VBZ cord-005453-4057qib7 7467 12 at at IN cord-005453-4057qib7 7467 13 presentation presentation NN cord-005453-4057qib7 7467 14 . . . cord-005453-4057qib7 7468 1 Methods method NNS cord-005453-4057qib7 7468 2 : : : cord-005453-4057qib7 7469 1 A a DT cord-005453-4057qib7 7469 2 study study NN cord-005453-4057qib7 7469 3 on on IN cord-005453-4057qib7 7469 4 209 209 CD cord-005453-4057qib7 7469 5 AYA AYA NNP cord-005453-4057qib7 7469 6 ( ( -LRB- cord-005453-4057qib7 7469 7 age age NN cord-005453-4057qib7 7469 8 14 14 CD cord-005453-4057qib7 7469 9 - - SYM cord-005453-4057qib7 7469 10 39 39 CD cord-005453-4057qib7 7469 11 years year NNS cord-005453-4057qib7 7469 12 ) ) -RRB- cord-005453-4057qib7 7469 13 , , , cord-005453-4057qib7 7469 14 who who WP cord-005453-4057qib7 7469 15 underwent undergo VBD cord-005453-4057qib7 7469 16 Allogenic Allogenic NNP cord-005453-4057qib7 7469 17 HSCT HSCT NNP cord-005453-4057qib7 7469 18 at at IN cord-005453-4057qib7 7469 19 our -PRON- PRP$ cord-005453-4057qib7 7469 20 institute institute NN cord-005453-4057qib7 7469 21 for for IN cord-005453-4057qib7 7469 22 Philadelphia Philadelphia NNP cord-005453-4057qib7 7469 23 negative negative JJ cord-005453-4057qib7 7469 24 ALL all DT cord-005453-4057qib7 7469 25 , , , cord-005453-4057qib7 7469 26 between between IN cord-005453-4057qib7 7469 27 February February NNP cord-005453-4057qib7 7469 28 2005 2005 CD cord-005453-4057qib7 7469 29 and and CC cord-005453-4057qib7 7469 30 December December NNP cord-005453-4057qib7 7469 31 2015 2015 CD cord-005453-4057qib7 7469 32 . . . cord-005453-4057qib7 7470 1 All all PDT cord-005453-4057qib7 7470 2 the the DT cord-005453-4057qib7 7470 3 studied study VBN cord-005453-4057qib7 7470 4 patients patient NNS cord-005453-4057qib7 7470 5 received receive VBD cord-005453-4057qib7 7470 6 CALGB CALGB NNP cord-005453-4057qib7 7470 7 based base VBN cord-005453-4057qib7 7470 8 adult adult NN cord-005453-4057qib7 7470 9 chemotherapy chemotherapy NN cord-005453-4057qib7 7470 10 protocol protocol NN cord-005453-4057qib7 7470 11 for for IN cord-005453-4057qib7 7470 12 induction induction NN cord-005453-4057qib7 7470 13 , , , cord-005453-4057qib7 7470 14 and and CC cord-005453-4057qib7 7470 15 underwent undergo VBD cord-005453-4057qib7 7470 16 a a DT cord-005453-4057qib7 7470 17 Matched match VBN cord-005453-4057qib7 7470 18 Related Related NNP cord-005453-4057qib7 7470 19 Donor Donor NNP cord-005453-4057qib7 7470 20 ( ( -LRB- cord-005453-4057qib7 7470 21 MRD MRD NNP cord-005453-4057qib7 7470 22 ) ) -RRB- cord-005453-4057qib7 7470 23 transplant transplant NN cord-005453-4057qib7 7470 24 with with IN cord-005453-4057qib7 7470 25 CY CY NNP cord-005453-4057qib7 7470 26 / / SYM cord-005453-4057qib7 7470 27 TBI TBI NNP cord-005453-4057qib7 7470 28 conditioning conditioning NN cord-005453-4057qib7 7470 29 and and CC cord-005453-4057qib7 7470 30 MTX MTX NNP cord-005453-4057qib7 7470 31 / / SYM cord-005453-4057qib7 7470 32 CSA CSA NNP cord-005453-4057qib7 7470 33 as as IN cord-005453-4057qib7 7470 34 GVHD GVHD NNP cord-005453-4057qib7 7470 35 prophylaxis prophylaxis NN cord-005453-4057qib7 7470 36 . . . cord-005453-4057qib7 7471 1 The the DT cord-005453-4057qib7 7471 2 patients patient NNS cord-005453-4057qib7 7471 3 were be VBD cord-005453-4057qib7 7471 4 eligible eligible JJ cord-005453-4057qib7 7471 5 for for IN cord-005453-4057qib7 7471 6 Allogeneic Allogeneic NNP cord-005453-4057qib7 7471 7 HSCT HSCT NNP cord-005453-4057qib7 7471 8 , , , cord-005453-4057qib7 7471 9 if if IN cord-005453-4057qib7 7471 10 they -PRON- PRP cord-005453-4057qib7 7471 11 have have VBP cord-005453-4057qib7 7471 12 a a DT cord-005453-4057qib7 7471 13 MRD MRD NNP cord-005453-4057qib7 7471 14 plus plus CC cord-005453-4057qib7 7471 15 one one CD cord-005453-4057qib7 7471 16 or or CC cord-005453-4057qib7 7471 17 more more JJR cord-005453-4057qib7 7471 18 of of IN cord-005453-4057qib7 7471 19 the the DT cord-005453-4057qib7 7471 20 following follow VBG cord-005453-4057qib7 7471 21 risk risk NN cord-005453-4057qib7 7471 22 factors factor NNS cord-005453-4057qib7 7471 23 : : : cord-005453-4057qib7 7471 24 ( ( -LRB- cord-005453-4057qib7 7471 25 1 1 LS cord-005453-4057qib7 7471 26 ) ) -RRB- cord-005453-4057qib7 7472 1 Age age NN cord-005453-4057qib7 7472 2 ˃ ˃ . cord-005453-4057qib7 7473 1 30 30 CD cord-005453-4057qib7 7473 2 years year NNS cord-005453-4057qib7 7473 3 , , , cord-005453-4057qib7 7474 1 ( ( -LRB- cord-005453-4057qib7 7474 2 2 2 LS cord-005453-4057qib7 7474 3 ) ) -RRB- cord-005453-4057qib7 7474 4 High high JJ cord-005453-4057qib7 7474 5 presenting present VBG cord-005453-4057qib7 7474 6 WBC WBC NNP cord-005453-4057qib7 7474 7 count count NN cord-005453-4057qib7 7474 8 ( ( -LRB- cord-005453-4057qib7 7474 9 > > NFP cord-005453-4057qib7 7474 10 30 30 CD cord-005453-4057qib7 7474 11 for for IN cord-005453-4057qib7 7474 12 B b NN cord-005453-4057qib7 7474 13 - - HYPH cord-005453-4057qib7 7474 14 ALL all DT cord-005453-4057qib7 7474 15 , , , cord-005453-4057qib7 7474 16 > > XX cord-005453-4057qib7 7474 17 100 100 CD cord-005453-4057qib7 7474 18 for for IN cord-005453-4057qib7 7474 19 T T NNP cord-005453-4057qib7 7474 20 - - HYPH cord-005453-4057qib7 7474 21 ALL ALL NNP cord-005453-4057qib7 7474 22 ) ) -RRB- cord-005453-4057qib7 7474 23 , , , cord-005453-4057qib7 7474 24 ( ( -LRB- cord-005453-4057qib7 7474 25 3 3 LS cord-005453-4057qib7 7474 26 ) ) -RRB- cord-005453-4057qib7 7474 27 High high JJ cord-005453-4057qib7 7474 28 risk risk NN cord-005453-4057qib7 7475 1 Immuno immuno JJ cord-005453-4057qib7 7475 2 - - HYPH cord-005453-4057qib7 7475 3 phenotyping phenotyping JJ cord-005453-4057qib7 7475 4 ( ( -LRB- cord-005453-4057qib7 7475 5 Pro pro JJ cord-005453-4057qib7 7475 6 - - NN cord-005453-4057qib7 7475 7 B b JJ cord-005453-4057qib7 7475 8 , , , cord-005453-4057qib7 7475 9 Pro Pro NNP cord-005453-4057qib7 7475 10 - - HYPH cord-005453-4057qib7 7475 11 T t JJ cord-005453-4057qib7 7475 12 , , , cord-005453-4057qib7 7475 13 Early Early NNP cord-005453-4057qib7 7475 14 T T NNP cord-005453-4057qib7 7475 15 , , , cord-005453-4057qib7 7475 16 and and CC cord-005453-4057qib7 7475 17 Mature Mature NNP cord-005453-4057qib7 7475 18 T T NNP cord-005453-4057qib7 7475 19 ) ) -RRB- cord-005453-4057qib7 7475 20 , , . cord-005453-4057qib7 7476 1 ( ( -LRB- cord-005453-4057qib7 7476 2 4 4 LS cord-005453-4057qib7 7476 3 ) ) -RRB- cord-005453-4057qib7 7476 4 Bulky bulky JJ cord-005453-4057qib7 7476 5 splenomegaly splenomegaly NN cord-005453-4057qib7 7476 6 or or CC cord-005453-4057qib7 7476 7 bulky bulky JJ cord-005453-4057qib7 7476 8 lymphadenopathy lymphadenopathy NN cord-005453-4057qib7 7476 9 , , , cord-005453-4057qib7 7476 10 ( ( -LRB- cord-005453-4057qib7 7476 11 5 5 LS cord-005453-4057qib7 7476 12 ) ) -RRB- cord-005453-4057qib7 7476 13 High high JJ cord-005453-4057qib7 7476 14 risk risk NN cord-005453-4057qib7 7476 15 cytogenetics cytogenetic NNS cord-005453-4057qib7 7476 16 ( ( -LRB- cord-005453-4057qib7 7476 17 4;11 4;11 CD cord-005453-4057qib7 7476 18 , , , cord-005453-4057qib7 7476 19 1;19 1;19 CD cord-005453-4057qib7 7476 20 , , , cord-005453-4057qib7 7476 21 low low JJ cord-005453-4057qib7 7476 22 hypodiploidy hypodiploidy NNP cord-005453-4057qib7 7476 23 / / , cord-005453-4057qib7 7476 24 near near IN cord-005453-4057qib7 7476 25 triploidy triploidy NNP cord-005453-4057qib7 7476 26 , , , cord-005453-4057qib7 7476 27 complex complex NNP cord-005453-4057qib7 7476 28 ) ) -RRB- cord-005453-4057qib7 7476 29 , , , cord-005453-4057qib7 7476 30 ( ( -LRB- cord-005453-4057qib7 7476 31 6 6 CD cord-005453-4057qib7 7476 32 ) ) -RRB- cord-005453-4057qib7 7476 33 CNS CNS NNP cord-005453-4057qib7 7476 34 involvement involvement NN cord-005453-4057qib7 7476 35 , , , cord-005453-4057qib7 7476 36 ( ( -LRB- cord-005453-4057qib7 7476 37 7 7 LS cord-005453-4057qib7 7476 38 ) ) -RRB- cord-005453-4057qib7 7476 39 Relapsed relapsed JJ cord-005453-4057qib7 7476 40 or or CC cord-005453-4057qib7 7476 41 refractory refractory JJ cord-005453-4057qib7 7476 42 disease disease NN cord-005453-4057qib7 7476 43 at at IN cord-005453-4057qib7 7476 44 D28 D28 NNP cord-005453-4057qib7 7476 45 of of IN cord-005453-4057qib7 7476 46 induction induction NN cord-005453-4057qib7 7476 47 . . . cord-005453-4057qib7 7477 1 In in IN cord-005453-4057qib7 7477 2 this this DT cord-005453-4057qib7 7477 3 study study NN cord-005453-4057qib7 7477 4 , , , cord-005453-4057qib7 7477 5 we -PRON- PRP cord-005453-4057qib7 7477 6 investigated investigate VBD cord-005453-4057qib7 7477 7 the the DT cord-005453-4057qib7 7477 8 impact impact NN cord-005453-4057qib7 7477 9 of of IN cord-005453-4057qib7 7477 10 those those DT cord-005453-4057qib7 7477 11 different different JJ cord-005453-4057qib7 7477 12 risk risk NN cord-005453-4057qib7 7477 13 factors factor NNS cord-005453-4057qib7 7477 14 on on IN cord-005453-4057qib7 7477 15 the the DT cord-005453-4057qib7 7477 16 long long JJ cord-005453-4057qib7 7477 17 term term NN cord-005453-4057qib7 7477 18 outcome outcome NN cord-005453-4057qib7 7477 19 of of IN cord-005453-4057qib7 7477 20 Allogeneic Allogeneic NNP cord-005453-4057qib7 7477 21 HSCT HSCT NNP cord-005453-4057qib7 7477 22 . . . cord-005453-4057qib7 7478 1 Results result NNS cord-005453-4057qib7 7478 2 : : : cord-005453-4057qib7 7479 1 The the DT cord-005453-4057qib7 7479 2 median median JJ cord-005453-4057qib7 7479 3 OS os NN cord-005453-4057qib7 7479 4 of of IN cord-005453-4057qib7 7479 5 our -PRON- PRP$ cord-005453-4057qib7 7479 6 studied study VBN cord-005453-4057qib7 7479 7 patients patient NNS cord-005453-4057qib7 7479 8 was be VBD cord-005453-4057qib7 7479 9 not not RB cord-005453-4057qib7 7479 10 reached reach VBN cord-005453-4057qib7 7479 11 at at IN cord-005453-4057qib7 7479 12 12.5 12.5 CD cord-005453-4057qib7 7479 13 years year NNS cord-005453-4057qib7 7479 14 , , , cord-005453-4057qib7 7479 15 with with IN cord-005453-4057qib7 7479 16 a a DT cord-005453-4057qib7 7479 17 median median JJ cord-005453-4057qib7 7479 18 DFS DFS NNP cord-005453-4057qib7 7479 19 of of IN cord-005453-4057qib7 7479 20 8.3 8.3 CD cord-005453-4057qib7 7479 21 years year NNS cord-005453-4057qib7 7480 1 ( ( -LRB- cord-005453-4057qib7 7480 2 Figure figure NN cord-005453-4057qib7 7480 3 1 1 CD cord-005453-4057qib7 7480 4 ) ) -RRB- cord-005453-4057qib7 7480 5 . . . cord-005453-4057qib7 7481 1 In in IN cord-005453-4057qib7 7481 2 a a DT cord-005453-4057qib7 7481 3 univariate univariate JJ cord-005453-4057qib7 7481 4 analysis analysis NN cord-005453-4057qib7 7481 5 , , , cord-005453-4057qib7 7481 6 relapsed relapsed JJ cord-005453-4057qib7 7481 7 or or CC cord-005453-4057qib7 7481 8 refractory refractory JJ cord-005453-4057qib7 7481 9 disease disease NN cord-005453-4057qib7 7481 10 prior prior RB cord-005453-4057qib7 7481 11 to to IN cord-005453-4057qib7 7481 12 transplant transplant NN cord-005453-4057qib7 7481 13 was be VBD cord-005453-4057qib7 7481 14 the the DT cord-005453-4057qib7 7481 15 only only JJ cord-005453-4057qib7 7481 16 independent independent JJ cord-005453-4057qib7 7481 17 risk risk NN cord-005453-4057qib7 7481 18 factor factor NN cord-005453-4057qib7 7481 19 for for IN cord-005453-4057qib7 7481 20 OS OS NNP cord-005453-4057qib7 7481 21 and and CC cord-005453-4057qib7 7481 22 DFS DFS NNP cord-005453-4057qib7 7481 23 ( ( -LRB- cord-005453-4057qib7 7481 24 p p NN cord-005453-4057qib7 7481 25 - - HYPH cord-005453-4057qib7 7481 26 value= value= NN cord-005453-4057qib7 7481 27 0.36 0.36 CD cord-005453-4057qib7 7481 28 , , , cord-005453-4057qib7 7481 29 and and CC cord-005453-4057qib7 7481 30 0.01 0.01 CD cord-005453-4057qib7 7481 31 respectively respectively RB cord-005453-4057qib7 7481 32 ) ) -RRB- cord-005453-4057qib7 7482 1 ( ( -LRB- cord-005453-4057qib7 7482 2 Figure figure NN cord-005453-4057qib7 7482 3 2 2 CD cord-005453-4057qib7 7482 4 ) ) -RRB- cord-005453-4057qib7 7482 5 . . . cord-005453-4057qib7 7483 1 In in IN cord-005453-4057qib7 7483 2 addition addition NN cord-005453-4057qib7 7483 3 , , , cord-005453-4057qib7 7483 4 patients patient NNS cord-005453-4057qib7 7483 5 who who WP cord-005453-4057qib7 7483 6 had have VBD cord-005453-4057qib7 7483 7 3 3 CD cord-005453-4057qib7 7483 8 or or CC cord-005453-4057qib7 7483 9 more more JJR cord-005453-4057qib7 7483 10 risk risk NN cord-005453-4057qib7 7483 11 factors factor NNS cord-005453-4057qib7 7483 12 ( ( -LRB- cord-005453-4057qib7 7483 13 41 41 CD cord-005453-4057qib7 7483 14 , , , cord-005453-4057qib7 7483 15 19.6 19.6 CD cord-005453-4057qib7 7483 16 % % NN cord-005453-4057qib7 7483 17 ) ) -RRB- cord-005453-4057qib7 7483 18 prior prior RB cord-005453-4057qib7 7483 19 to to IN cord-005453-4057qib7 7483 20 transplant transplant NN cord-005453-4057qib7 7483 21 had have VBD cord-005453-4057qib7 7483 22 a a DT cord-005453-4057qib7 7483 23 significantly significantly RB cord-005453-4057qib7 7483 24 lower low JJR cord-005453-4057qib7 7483 25 long long JJ cord-005453-4057qib7 7483 26 term term NN cord-005453-4057qib7 7483 27 outcome outcome NN cord-005453-4057qib7 7483 28 compared compare VBN cord-005453-4057qib7 7483 29 to to IN cord-005453-4057qib7 7483 30 patients patient NNS cord-005453-4057qib7 7483 31 , , , cord-005453-4057qib7 7483 32 who who WP cord-005453-4057qib7 7483 33 had have VBD cord-005453-4057qib7 7483 34 one one CD cord-005453-4057qib7 7483 35 ( ( -LRB- cord-005453-4057qib7 7483 36 100 100 CD cord-005453-4057qib7 7483 37 , , , cord-005453-4057qib7 7483 38 47.9 47.9 CD cord-005453-4057qib7 7483 39 % % NN cord-005453-4057qib7 7483 40 ) ) -RRB- cord-005453-4057qib7 7483 41 or or CC cord-005453-4057qib7 7483 42 two two CD cord-005453-4057qib7 7483 43 risk risk NN cord-005453-4057qib7 7483 44 factors factor NNS cord-005453-4057qib7 7483 45 ( ( -LRB- cord-005453-4057qib7 7483 46 68 68 CD cord-005453-4057qib7 7483 47 , , , cord-005453-4057qib7 7483 48 32.5 32.5 CD cord-005453-4057qib7 7483 49 % % NN cord-005453-4057qib7 7483 50 ) ) -RRB- cord-005453-4057qib7 7483 51 with with IN cord-005453-4057qib7 7483 52 a a DT cord-005453-4057qib7 7483 53 median median JJ cord-005453-4057qib7 7483 54 OS os NN cord-005453-4057qib7 7483 55 of of IN cord-005453-4057qib7 7483 56 23 23 CD cord-005453-4057qib7 7483 57 months month NNS cord-005453-4057qib7 7483 58 , , , cord-005453-4057qib7 7483 59 and and CC cord-005453-4057qib7 7483 60 a a DT cord-005453-4057qib7 7483 61 median median JJ cord-005453-4057qib7 7483 62 DFS DFS NNP cord-005453-4057qib7 7483 63 of of IN cord-005453-4057qib7 7483 64 only only RB cord-005453-4057qib7 7483 65 11 11 CD cord-005453-4057qib7 7483 66 months month NNS cord-005453-4057qib7 7483 67 ( ( -LRB- cord-005453-4057qib7 7483 68 p p NN cord-005453-4057qib7 7483 69 - - : cord-005453-4057qib7 7483 70 value=0.32 value=0.32 NNP cord-005453-4057qib7 7483 71 , , , cord-005453-4057qib7 7483 72 and and CC cord-005453-4057qib7 7483 73 0.009 0.009 CD cord-005453-4057qib7 7483 74 respectively respectively RB cord-005453-4057qib7 7483 75 ) ) -RRB- cord-005453-4057qib7 7484 1 ( ( -LRB- cord-005453-4057qib7 7484 2 Figure figure NN cord-005453-4057qib7 7484 3 3 3 CD cord-005453-4057qib7 7484 4 ) ) -RRB- cord-005453-4057qib7 7484 5 . . . cord-005453-4057qib7 7485 1 Conclusions conclusion NNS cord-005453-4057qib7 7485 2 : : : cord-005453-4057qib7 7486 1 Our -PRON- PRP$ cord-005453-4057qib7 7486 2 results result NNS cord-005453-4057qib7 7486 3 show show VBP cord-005453-4057qib7 7486 4 that that IN cord-005453-4057qib7 7486 5 the the DT cord-005453-4057qib7 7486 6 long long JJ cord-005453-4057qib7 7486 7 term term NN cord-005453-4057qib7 7486 8 outcomes outcome NNS cord-005453-4057qib7 7486 9 of of IN cord-005453-4057qib7 7486 10 HSCT HSCT NNP cord-005453-4057qib7 7486 11 in in IN cord-005453-4057qib7 7486 12 AYA AYA NNP cord-005453-4057qib7 7486 13 with with IN cord-005453-4057qib7 7486 14 Philadelphia Philadelphia NNP cord-005453-4057qib7 7486 15 negative negative NN cord-005453-4057qib7 7486 16 ALL all DT cord-005453-4057qib7 7486 17 treated treat VBN cord-005453-4057qib7 7486 18 on on IN cord-005453-4057qib7 7486 19 an an DT cord-005453-4057qib7 7486 20 adult adult NN cord-005453-4057qib7 7486 21 type type NN cord-005453-4057qib7 7486 22 chemotherapy chemotherapy NN cord-005453-4057qib7 7486 23 regimen regimen NN cord-005453-4057qib7 7486 24 , , , cord-005453-4057qib7 7486 25 were be VBD cord-005453-4057qib7 7486 26 significantly significantly RB cord-005453-4057qib7 7486 27 better well JJR cord-005453-4057qib7 7486 28 in in IN cord-005453-4057qib7 7486 29 patients patient NNS cord-005453-4057qib7 7486 30 who who WP cord-005453-4057qib7 7486 31 showed show VBD cord-005453-4057qib7 7486 32 a a DT cord-005453-4057qib7 7486 33 good good JJ cord-005453-4057qib7 7486 34 response response NN cord-005453-4057qib7 7486 35 to to IN cord-005453-4057qib7 7486 36 initial initial JJ cord-005453-4057qib7 7486 37 therapy therapy NN cord-005453-4057qib7 7486 38 and and CC cord-005453-4057qib7 7486 39 a a DT cord-005453-4057qib7 7486 40 limited limited JJ cord-005453-4057qib7 7486 41 poor poor JJ cord-005453-4057qib7 7486 42 prognostic prognostic JJ cord-005453-4057qib7 7486 43 factors factor NNS cord-005453-4057qib7 7486 44 at at IN cord-005453-4057qib7 7486 45 presentation presentation NN cord-005453-4057qib7 7486 46 , , , cord-005453-4057qib7 7486 47 with with IN cord-005453-4057qib7 7486 48 worsening worsen VBG cord-005453-4057qib7 7486 49 of of IN cord-005453-4057qib7 7486 50 DFS DFS NNP cord-005453-4057qib7 7486 51 as as IN cord-005453-4057qib7 7486 52 the the DT cord-005453-4057qib7 7486 53 number number NN cord-005453-4057qib7 7486 54 of of IN cord-005453-4057qib7 7486 55 poor poor JJ cord-005453-4057qib7 7486 56 prognostic prognostic JJ cord-005453-4057qib7 7486 57 features feature NNS cord-005453-4057qib7 7486 58 increase increase NN cord-005453-4057qib7 7486 59 . . . cord-005453-4057qib7 7487 1 We -PRON- PRP cord-005453-4057qib7 7487 2 can can MD cord-005453-4057qib7 7487 3 conclude conclude VB cord-005453-4057qib7 7487 4 that that IN cord-005453-4057qib7 7487 5 , , , cord-005453-4057qib7 7487 6 using use VBG cord-005453-4057qib7 7487 7 this this DT cord-005453-4057qib7 7487 8 risk risk NN cord-005453-4057qib7 7487 9 score score NN cord-005453-4057qib7 7487 10 can can MD cord-005453-4057qib7 7487 11 be be VB cord-005453-4057qib7 7487 12 helpful helpful JJ cord-005453-4057qib7 7487 13 in in IN cord-005453-4057qib7 7487 14 predicting predict VBG cord-005453-4057qib7 7487 15 the the DT cord-005453-4057qib7 7487 16 outcome outcome NN cord-005453-4057qib7 7487 17 of of IN cord-005453-4057qib7 7487 18 Allogenic Allogenic NNP cord-005453-4057qib7 7487 19 HSCT HSCT NNP cord-005453-4057qib7 7487 20 in in IN cord-005453-4057qib7 7487 21 AYA AYA NNP cord-005453-4057qib7 7487 22 with with IN cord-005453-4057qib7 7487 23 Philadelphia Philadelphia NNP cord-005453-4057qib7 7487 24 negative negative NN cord-005453-4057qib7 7487 25 ALL all DT cord-005453-4057qib7 7487 26 treated treat VBN cord-005453-4057qib7 7487 27 with with IN cord-005453-4057qib7 7487 28 adult adult NN cord-005453-4057qib7 7487 29 type type NN cord-005453-4057qib7 7487 30 chemotherapy chemotherapy NN cord-005453-4057qib7 7487 31 protocol protocol NN cord-005453-4057qib7 7487 32 . . . cord-005453-4057qib7 7488 1 Disclosure disclosure NN cord-005453-4057qib7 7488 2 : : : cord-005453-4057qib7 7488 3 No no DT cord-005453-4057qib7 7488 4 conflict conflict NN cord-005453-4057qib7 7488 5 of of IN cord-005453-4057qib7 7488 6 interest interest NN cord-005453-4057qib7 7489 1 A a DT cord-005453-4057qib7 7489 2 prospective prospective JJ cord-005453-4057qib7 7489 3 single single JJ cord-005453-4057qib7 7489 4 center center NN cord-005453-4057qib7 7489 5 survey survey NN cord-005453-4057qib7 7489 6 on on IN cord-005453-4057qib7 7489 7 donor donor NN cord-005453-4057qib7 7489 8 - - HYPH cord-005453-4057qib7 7489 9 specific specific JJ cord-005453-4057qib7 7489 10 anti anti JJ cord-005453-4057qib7 7489 11 - - JJ cord-005453-4057qib7 7489 12 HLA HLA NNP cord-005453-4057qib7 7489 13 antibodies antibody NNS cord-005453-4057qib7 7489 14 and and CC cord-005453-4057qib7 7489 15 desensitization desensitization NN cord-005453-4057qib7 7489 16 strategy strategy NN cord-005453-4057qib7 7489 17 in in IN cord-005453-4057qib7 7489 18 patients patient NNS cord-005453-4057qib7 7489 19 undergoing undergo VBG cord-005453-4057qib7 7489 20 an an DT cord-005453-4057qib7 7489 21 allogeneic allogeneic NN cord-005453-4057qib7 7489 22 stem stem NN cord-005453-4057qib7 7489 23 cell cell NN cord-005453-4057qib7 7489 24 transplant transplant NN cord-005453-4057qib7 7489 25 Background background NN cord-005453-4057qib7 7489 26 : : : cord-005453-4057qib7 7490 1 In in IN cord-005453-4057qib7 7490 2 the the DT cord-005453-4057qib7 7490 3 setting setting NN cord-005453-4057qib7 7490 4 of of IN cord-005453-4057qib7 7490 5 hematopoietic hematopoietic JJ cord-005453-4057qib7 7490 6 stem stem NN cord-005453-4057qib7 7490 7 cell cell NN cord-005453-4057qib7 7490 8 transplantation transplantation NN cord-005453-4057qib7 7490 9 ( ( -LRB- cord-005453-4057qib7 7490 10 HSCT HSCT NNP cord-005453-4057qib7 7490 11 ) ) -RRB- cord-005453-4057qib7 7490 12 , , , cord-005453-4057qib7 7490 13 considering consider VBG cord-005453-4057qib7 7490 14 the the DT cord-005453-4057qib7 7490 15 risk risk NN cord-005453-4057qib7 7490 16 of of IN cord-005453-4057qib7 7490 17 poor poor JJ cord-005453-4057qib7 7490 18 engraftment engraftment NN cord-005453-4057qib7 7490 19 or or CC cord-005453-4057qib7 7490 20 graft graft NN cord-005453-4057qib7 7490 21 failure failure NN cord-005453-4057qib7 7490 22 ( ( -LRB- cord-005453-4057qib7 7490 23 GF GF NNP cord-005453-4057qib7 7490 24 ) ) -RRB- cord-005453-4057qib7 7490 25 , , , cord-005453-4057qib7 7490 26 the the DT cord-005453-4057qib7 7490 27 detection detection NN cord-005453-4057qib7 7490 28 of of IN cord-005453-4057qib7 7490 29 antibodies antibody NNS cord-005453-4057qib7 7490 30 ( ( -LRB- cord-005453-4057qib7 7490 31 Ab Ab NNP cord-005453-4057qib7 7490 32 ) ) -RRB- cord-005453-4057qib7 7490 33 directed direct VBN cord-005453-4057qib7 7490 34 against against IN cord-005453-4057qib7 7490 35 donor donor NN cord-005453-4057qib7 7490 36 specific specific JJ cord-005453-4057qib7 7490 37 HLA HLA NNP cord-005453-4057qib7 7490 38 loci locus NNS cord-005453-4057qib7 7490 39 ( ( -LRB- cord-005453-4057qib7 7490 40 DSA DSA NNP cord-005453-4057qib7 7490 41 ) ) -RRB- cord-005453-4057qib7 7490 42 represents represent VBZ cord-005453-4057qib7 7490 43 a a DT cord-005453-4057qib7 7490 44 contraindication contraindication NN cord-005453-4057qib7 7490 45 to to TO cord-005453-4057qib7 7490 46 proceed proceed VB cord-005453-4057qib7 7490 47 with with IN cord-005453-4057qib7 7490 48 the the DT cord-005453-4057qib7 7490 49 same same JJ cord-005453-4057qib7 7490 50 donor donor NN cord-005453-4057qib7 7490 51 , , , cord-005453-4057qib7 7490 52 suggesting suggest VBG cord-005453-4057qib7 7490 53 the the DT cord-005453-4057qib7 7490 54 search search NN cord-005453-4057qib7 7490 55 of of IN cord-005453-4057qib7 7490 56 other other JJ cord-005453-4057qib7 7490 57 donors donor NNS cord-005453-4057qib7 7490 58 . . . cord-005453-4057qib7 7491 1 In in IN cord-005453-4057qib7 7491 2 many many JJ cord-005453-4057qib7 7491 3 cases case NNS cord-005453-4057qib7 7491 4 , , , cord-005453-4057qib7 7491 5 there there EX cord-005453-4057qib7 7491 6 is be VBZ cord-005453-4057qib7 7491 7 not not RB cord-005453-4057qib7 7491 8 sufficient sufficient JJ cord-005453-4057qib7 7491 9 time time NN cord-005453-4057qib7 7491 10 to to TO cord-005453-4057qib7 7491 11 search search VB cord-005453-4057qib7 7491 12 for for IN cord-005453-4057qib7 7491 13 alternative alternative JJ cord-005453-4057qib7 7491 14 donors donor NNS cord-005453-4057qib7 7491 15 and and CC cord-005453-4057qib7 7491 16 it -PRON- PRP cord-005453-4057qib7 7491 17 is be VBZ cord-005453-4057qib7 7491 18 necessary necessary JJ cord-005453-4057qib7 7491 19 to to TO cord-005453-4057qib7 7491 20 plan plan VB cord-005453-4057qib7 7491 21 an an DT cord-005453-4057qib7 7491 22 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 7491 23 strategy strategy NN cord-005453-4057qib7 7491 24 to to TO cord-005453-4057qib7 7491 25 decrease decrease VB cord-005453-4057qib7 7491 26 the the DT cord-005453-4057qib7 7491 27 DSA DSA NNP cord-005453-4057qib7 7491 28 level level NN cord-005453-4057qib7 7491 29 , , , cord-005453-4057qib7 7491 30 thus thus RB cord-005453-4057qib7 7491 31 reducing reduce VBG cord-005453-4057qib7 7491 32 the the DT cord-005453-4057qib7 7491 33 risk risk NN cord-005453-4057qib7 7491 34 of of IN cord-005453-4057qib7 7491 35 GF GF NNP cord-005453-4057qib7 7491 36 . . . cord-005453-4057qib7 7492 1 To to IN cord-005453-4057qib7 7492 2 date date NN cord-005453-4057qib7 7492 3 , , , cord-005453-4057qib7 7492 4 there there EX cord-005453-4057qib7 7492 5 is be VBZ cord-005453-4057qib7 7492 6 no no DT cord-005453-4057qib7 7492 7 consensus consensus NN cord-005453-4057qib7 7492 8 on on IN cord-005453-4057qib7 7492 9 desensitization desensitization NN cord-005453-4057qib7 7492 10 standards standard NNS cord-005453-4057qib7 7492 11 to to TO cord-005453-4057qib7 7492 12 manage manage VB cord-005453-4057qib7 7492 13 DSAs dsa NNS cord-005453-4057qib7 7492 14 in in IN cord-005453-4057qib7 7492 15 HSCT HSCT NNP cord-005453-4057qib7 7492 16 . . . cord-005453-4057qib7 7493 1 The the DT cord-005453-4057qib7 7493 2 aim aim NN cord-005453-4057qib7 7493 3 of of IN cord-005453-4057qib7 7493 4 this this DT cord-005453-4057qib7 7493 5 study study NN cord-005453-4057qib7 7493 6 was be VBD cord-005453-4057qib7 7493 7 to to TO cord-005453-4057qib7 7493 8 determine determine VB cord-005453-4057qib7 7493 9 the the DT cord-005453-4057qib7 7493 10 incidence incidence NN cord-005453-4057qib7 7493 11 of of IN cord-005453-4057qib7 7493 12 anti anti JJ cord-005453-4057qib7 7493 13 - - JJ cord-005453-4057qib7 7493 14 HLA HLA NNP cord-005453-4057qib7 7493 15 Ab Ab NNP cord-005453-4057qib7 7493 16 and and CC cord-005453-4057qib7 7493 17 DSAs dsa NNS cord-005453-4057qib7 7493 18 in in IN cord-005453-4057qib7 7493 19 hematologic hematologic JJ cord-005453-4057qib7 7493 20 patients patient NNS cord-005453-4057qib7 7493 21 candidate candidate NN cord-005453-4057qib7 7493 22 to to IN cord-005453-4057qib7 7493 23 an an DT cord-005453-4057qib7 7493 24 allogeneic allogeneic JJ cord-005453-4057qib7 7493 25 HSCT HSCT NNP cord-005453-4057qib7 7493 26 , , , cord-005453-4057qib7 7493 27 and and CC cord-005453-4057qib7 7493 28 the the DT cord-005453-4057qib7 7493 29 efficacy efficacy NN cord-005453-4057qib7 7493 30 of of IN cord-005453-4057qib7 7493 31 our -PRON- PRP$ cord-005453-4057qib7 7493 32 desensitization desensitization NN cord-005453-4057qib7 7493 33 protocol protocol NN cord-005453-4057qib7 7493 34 . . . cord-005453-4057qib7 7494 1 Here here RB cord-005453-4057qib7 7494 2 , , , cord-005453-4057qib7 7494 3 we -PRON- PRP cord-005453-4057qib7 7494 4 present present VBP cord-005453-4057qib7 7494 5 an an DT cord-005453-4057qib7 7494 6 update update NN cord-005453-4057qib7 7494 7 of of IN cord-005453-4057qib7 7494 8 the the DT cord-005453-4057qib7 7494 9 results result NNS cord-005453-4057qib7 7494 10 obtained obtain VBN cord-005453-4057qib7 7494 11 with with IN cord-005453-4057qib7 7494 12 our -PRON- PRP$ cord-005453-4057qib7 7494 13 strategy strategy NN cord-005453-4057qib7 7494 14 . . . cord-005453-4057qib7 7495 1 Methods method NNS cord-005453-4057qib7 7495 2 : : : cord-005453-4057qib7 7496 1 Between between IN cord-005453-4057qib7 7496 2 August August NNP cord-005453-4057qib7 7496 3 2014 2014 CD cord-005453-4057qib7 7496 4 and and CC cord-005453-4057qib7 7496 5 September September NNP cord-005453-4057qib7 7496 6 2018 2018 CD cord-005453-4057qib7 7496 7 , , , cord-005453-4057qib7 7496 8 we -PRON- PRP cord-005453-4057qib7 7496 9 prospectively prospectively RB cord-005453-4057qib7 7496 10 screened screen VBD cord-005453-4057qib7 7496 11 for for IN cord-005453-4057qib7 7496 12 DSA DSA NNP cord-005453-4057qib7 7496 13 140 140 CD cord-005453-4057qib7 7496 14 consecutive consecutive JJ cord-005453-4057qib7 7496 15 patients patient NNS cord-005453-4057qib7 7496 16 candidates candidate NNS cord-005453-4057qib7 7496 17 to to IN cord-005453-4057qib7 7496 18 an an DT cord-005453-4057qib7 7496 19 allogeneic allogeneic JJ cord-005453-4057qib7 7496 20 HSCT HSCT NNP cord-005453-4057qib7 7496 21 . . . cord-005453-4057qib7 7497 1 Anti Anti NNP cord-005453-4057qib7 7497 2 - - NNP cord-005453-4057qib7 7497 3 HLA HLA NNP cord-005453-4057qib7 7497 4 Ab Ab NNP cord-005453-4057qib7 7497 5 research research NN cord-005453-4057qib7 7497 6 was be VBD cord-005453-4057qib7 7497 7 carried carry VBN cord-005453-4057qib7 7497 8 out out RP cord-005453-4057qib7 7497 9 using use VBG cord-005453-4057qib7 7497 10 the the DT cord-005453-4057qib7 7497 11 Luminex Luminex NNP cord-005453-4057qib7 7497 12 bead bead NN cord-005453-4057qib7 7497 13 assay assay NN cord-005453-4057qib7 7497 14 ( ( -LRB- cord-005453-4057qib7 7497 15 Lifecode Lifecode NNP cord-005453-4057qib7 7497 16 Screen Screen NNP cord-005453-4057qib7 7497 17 and and CC cord-005453-4057qib7 7497 18 LSA LSA NNP cord-005453-4057qib7 7497 19 I I NNP cord-005453-4057qib7 7497 20 / / SYM cord-005453-4057qib7 7497 21 II II NNP cord-005453-4057qib7 7497 22 - - HYPH cord-005453-4057qib7 7497 23 Immucor Immucor NNP cord-005453-4057qib7 7497 24 ) ) -RRB- cord-005453-4057qib7 7497 25 . . . cord-005453-4057qib7 7498 1 The the DT cord-005453-4057qib7 7498 2 results result NNS cord-005453-4057qib7 7498 3 were be VBD cord-005453-4057qib7 7498 4 expressed express VBN cord-005453-4057qib7 7498 5 as as IN cord-005453-4057qib7 7498 6 mean mean JJ cord-005453-4057qib7 7498 7 fluorescence fluorescence NN cord-005453-4057qib7 7498 8 intensity intensity NN cord-005453-4057qib7 7498 9 ( ( -LRB- cord-005453-4057qib7 7498 10 MFI MFI NNP cord-005453-4057qib7 7498 11 ) ) -RRB- cord-005453-4057qib7 7498 12 ; ; : cord-005453-4057qib7 7498 13 MFI MFI NNP cord-005453-4057qib7 7498 14 > > XX cord-005453-4057qib7 7498 15 1000 1000 CD cord-005453-4057qib7 7498 16 was be VBD cord-005453-4057qib7 7498 17 considered consider VBN cord-005453-4057qib7 7498 18 positive positive JJ cord-005453-4057qib7 7498 19 . . . cord-005453-4057qib7 7499 1 In in IN cord-005453-4057qib7 7499 2 case case NN cord-005453-4057qib7 7499 3 of of IN cord-005453-4057qib7 7499 4 a a DT cord-005453-4057qib7 7499 5 mismatched mismatched JJ cord-005453-4057qib7 7499 6 related related JJ cord-005453-4057qib7 7499 7 donor donor NN cord-005453-4057qib7 7499 8 , , , cord-005453-4057qib7 7499 9 a a DT cord-005453-4057qib7 7499 10 flow flow NN cord-005453-4057qib7 7499 11 cytometric cytometric NNP cord-005453-4057qib7 7499 12 crossmatch crossmatch NN cord-005453-4057qib7 7499 13 test test NN cord-005453-4057qib7 7499 14 ( ( -LRB- cord-005453-4057qib7 7499 15 FCXM FCXM NNP cord-005453-4057qib7 7499 16 ) ) -RRB- cord-005453-4057qib7 7499 17 was be VBD cord-005453-4057qib7 7499 18 performed perform VBN cord-005453-4057qib7 7499 19 . . . cord-005453-4057qib7 7500 1 If if IN cord-005453-4057qib7 7500 2 the the DT cord-005453-4057qib7 7500 3 patient patient NN cord-005453-4057qib7 7500 4 had have VBD cord-005453-4057qib7 7500 5 DSAs dsa NNS cord-005453-4057qib7 7500 6 and and CC cord-005453-4057qib7 7500 7 only only RB cord-005453-4057qib7 7500 8 one one CD cord-005453-4057qib7 7500 9 available available JJ cord-005453-4057qib7 7500 10 donor donor NN cord-005453-4057qib7 7500 11 , , , cord-005453-4057qib7 7500 12 a a DT cord-005453-4057qib7 7500 13 desensitization desensitization NN cord-005453-4057qib7 7500 14 strategy strategy NN cord-005453-4057qib7 7500 15 was be VBD cord-005453-4057qib7 7500 16 employed employ VBN cord-005453-4057qib7 7500 17 , , , cord-005453-4057qib7 7500 18 scheduled schedule VBN cord-005453-4057qib7 7500 19 with with IN cord-005453-4057qib7 7500 20 Rituximab Rituximab NNP cord-005453-4057qib7 7500 21 on on IN cord-005453-4057qib7 7500 22 day day NN cord-005453-4057qib7 7500 23 -15 -15 CD cord-005453-4057qib7 7500 24 , , , cord-005453-4057qib7 7500 25 single single JJ cord-005453-4057qib7 7500 26 - - HYPH cord-005453-4057qib7 7500 27 volume volume NN cord-005453-4057qib7 7500 28 plasmapheresis plasmapheresis NN cord-005453-4057qib7 7500 29 procedures procedure NNS cord-005453-4057qib7 7500 30 ( ( -LRB- cord-005453-4057qib7 7500 31 PP PP NNP cord-005453-4057qib7 7500 32 ) ) -RRB- cord-005453-4057qib7 7500 33 , , , cord-005453-4057qib7 7500 34 usually usually RB cord-005453-4057qib7 7500 35 on on IN cord-005453-4057qib7 7500 36 day day NN cord-005453-4057qib7 7500 37 -9 -9 NN cord-005453-4057qib7 7500 38 and and CC cord-005453-4057qib7 7500 39 -8 -8 NNP cord-005453-4057qib7 7500 40 , , , cord-005453-4057qib7 7500 41 intravenous intravenous JJ cord-005453-4057qib7 7500 42 immunoglobulins immunoglobulin NNS cord-005453-4057qib7 7500 43 on on IN cord-005453-4057qib7 7500 44 day day NN cord-005453-4057qib7 7500 45 -7 -7 NNP cord-005453-4057qib7 7500 46 , , , cord-005453-4057qib7 7500 47 infusion infusion NN cord-005453-4057qib7 7500 48 of of IN cord-005453-4057qib7 7500 49 HLA HLA NNP cord-005453-4057qib7 7500 50 selected select VBN cord-005453-4057qib7 7500 51 platelets platelet NNS cord-005453-4057qib7 7500 52 for for IN cord-005453-4057qib7 7500 53 DSA DSA NNP cord-005453-4057qib7 7500 54 absorption absorption NN cord-005453-4057qib7 7500 55 in in IN cord-005453-4057qib7 7500 56 case case NN cord-005453-4057qib7 7500 57 of of IN cord-005453-4057qib7 7500 58 persistent persistent JJ cord-005453-4057qib7 7500 59 antibodies antibody NNS cord-005453-4057qib7 7500 60 directed direct VBN cord-005453-4057qib7 7500 61 against against IN cord-005453-4057qib7 7500 62 class class NN cord-005453-4057qib7 7500 63 I -PRON- PRP cord-005453-4057qib7 7500 64 HLA HLA NNP cord-005453-4057qib7 7500 65 antigens antigen NNS cord-005453-4057qib7 7500 66 . . . cord-005453-4057qib7 7501 1 The the DT cord-005453-4057qib7 7501 2 aim aim NN cord-005453-4057qib7 7501 3 of of IN cord-005453-4057qib7 7501 4 this this DT cord-005453-4057qib7 7501 5 schedule schedule NN cord-005453-4057qib7 7501 6 was be VBD cord-005453-4057qib7 7501 7 to to TO cord-005453-4057qib7 7501 8 avoid avoid VB cord-005453-4057qib7 7501 9 interferences interference NNS cord-005453-4057qib7 7501 10 with with IN cord-005453-4057qib7 7501 11 chemotherapy chemotherapy NN cord-005453-4057qib7 7501 12 and and CC cord-005453-4057qib7 7501 13 anti anti JJ cord-005453-4057qib7 7501 14 - - JJ cord-005453-4057qib7 7501 15 T t JJ cord-005453-4057qib7 7501 16 - - HYPH cord-005453-4057qib7 7501 17 cell cell NN cord-005453-4057qib7 7501 18 globulins globulin NNS cord-005453-4057qib7 7501 19 , , , cord-005453-4057qib7 7501 20 infused infuse VBN cord-005453-4057qib7 7501 21 during during IN cord-005453-4057qib7 7501 22 condition condition NN cord-005453-4057qib7 7501 23 regimen regimen NN cord-005453-4057qib7 7501 24 Results result NNS cord-005453-4057qib7 7501 25 : : : cord-005453-4057qib7 7501 26 Since since IN cord-005453-4057qib7 7501 27 August August NNP cord-005453-4057qib7 7501 28 2014 2014 CD cord-005453-4057qib7 7501 29 , , , cord-005453-4057qib7 7501 30 140 140 CD cord-005453-4057qib7 7501 31 patients patient NNS cord-005453-4057qib7 7501 32 have have VBP cord-005453-4057qib7 7501 33 been be VBN cord-005453-4057qib7 7501 34 prospectively prospectively RB cord-005453-4057qib7 7501 35 screened screen VBN cord-005453-4057qib7 7501 36 . . . cord-005453-4057qib7 7502 1 Thirty thirty CD cord-005453-4057qib7 7502 2 - - HYPH cord-005453-4057qib7 7502 3 three three CD cord-005453-4057qib7 7502 4 patients patient NNS cord-005453-4057qib7 7502 5 ( ( -LRB- cord-005453-4057qib7 7502 6 23.6 23.6 CD cord-005453-4057qib7 7502 7 % % NN cord-005453-4057qib7 7502 8 ) ) -RRB- cord-005453-4057qib7 7502 9 showed show VBD cord-005453-4057qib7 7502 10 anti anti JJ cord-005453-4057qib7 7502 11 - - JJ cord-005453-4057qib7 7502 12 HLA HLA NNP cord-005453-4057qib7 7502 13 Ab Ab NNP cord-005453-4057qib7 7502 14 and and CC cord-005453-4057qib7 7502 15 9 9 CD cord-005453-4057qib7 7502 16 of of IN cord-005453-4057qib7 7502 17 them -PRON- PRP cord-005453-4057qib7 7502 18 ( ( -LRB- cord-005453-4057qib7 7502 19 6.4 6.4 CD cord-005453-4057qib7 7502 20 % % NN cord-005453-4057qib7 7502 21 ) ) -RRB- cord-005453-4057qib7 7502 22 had have VBD cord-005453-4057qib7 7502 23 DSAs dsa NNS cord-005453-4057qib7 7502 24 : : : cord-005453-4057qib7 7502 25 6 6 CD cord-005453-4057qib7 7502 26 were be VBD cord-005453-4057qib7 7502 27 treated treat VBN cord-005453-4057qib7 7502 28 with with IN cord-005453-4057qib7 7502 29 the the DT cord-005453-4057qib7 7502 30 desensitization desensitization NN cord-005453-4057qib7 7502 31 strategy strategy NN cord-005453-4057qib7 7502 32 , , , cord-005453-4057qib7 7502 33 applied apply VBD cord-005453-4057qib7 7502 34 according accord VBG cord-005453-4057qib7 7502 35 to to IN cord-005453-4057qib7 7502 36 the the DT cord-005453-4057qib7 7502 37 MFI MFI NNP cord-005453-4057qib7 7502 38 score score NN cord-005453-4057qib7 7502 39 and and CC cord-005453-4057qib7 7502 40 the the DT cord-005453-4057qib7 7502 41 FCXM FCXM NNP cord-005453-4057qib7 7502 42 result result NN cord-005453-4057qib7 7502 43 , , , cord-005453-4057qib7 7502 44 and and CC cord-005453-4057qib7 7502 45 all all DT cord-005453-4057qib7 7502 46 of of IN cord-005453-4057qib7 7502 47 them -PRON- PRP cord-005453-4057qib7 7502 48 obtained obtain VBD cord-005453-4057qib7 7502 49 an an DT cord-005453-4057qib7 7502 50 engraftment engraftment NN cord-005453-4057qib7 7502 51 ; ; : cord-005453-4057qib7 7502 52 in in IN cord-005453-4057qib7 7502 53 2 2 CD cord-005453-4057qib7 7502 54 cases case NNS cord-005453-4057qib7 7502 55 , , , cord-005453-4057qib7 7502 56 an an DT cord-005453-4057qib7 7502 57 alternative alternative JJ cord-005453-4057qib7 7502 58 donor donor NN cord-005453-4057qib7 7502 59 was be VBD cord-005453-4057qib7 7502 60 selected select VBN cord-005453-4057qib7 7502 61 and and CC cord-005453-4057qib7 7502 62 in in IN cord-005453-4057qib7 7502 63 1 1 CD cord-005453-4057qib7 7502 64 case case NN cord-005453-4057qib7 7502 65 the the DT cord-005453-4057qib7 7502 66 research research NN cord-005453-4057qib7 7502 67 for for IN cord-005453-4057qib7 7502 68 an an DT cord-005453-4057qib7 7502 69 alternative alternative JJ cord-005453-4057qib7 7502 70 donor donor NN cord-005453-4057qib7 7502 71 is be VBZ cord-005453-4057qib7 7502 72 still still RB cord-005453-4057qib7 7502 73 underway underway JJ cord-005453-4057qib7 7502 74 . . . cord-005453-4057qib7 7503 1 DSA DSA NNP cord-005453-4057qib7 7503 2 detection detection NN cord-005453-4057qib7 7503 3 was be VBD cord-005453-4057qib7 7503 4 performed perform VBN cord-005453-4057qib7 7503 5 every every DT cord-005453-4057qib7 7503 6 7 7 CD cord-005453-4057qib7 7503 7 days day NNS cord-005453-4057qib7 7503 8 after after IN cord-005453-4057qib7 7503 9 HSCT HSCT NNP cord-005453-4057qib7 7503 10 for for IN cord-005453-4057qib7 7503 11 the the DT cord-005453-4057qib7 7503 12 first first JJ cord-005453-4057qib7 7503 13 month month NN cord-005453-4057qib7 7503 14 and and CC cord-005453-4057qib7 7503 15 60 60 CD cord-005453-4057qib7 7503 16 , , , cord-005453-4057qib7 7503 17 180 180 CD cord-005453-4057qib7 7503 18 and and CC cord-005453-4057qib7 7503 19 365 365 CD cord-005453-4057qib7 7503 20 days day NNS cord-005453-4057qib7 7503 21 following follow VBG cord-005453-4057qib7 7503 22 HSCT HSCT NNP cord-005453-4057qib7 7503 23 . . . cord-005453-4057qib7 7504 1 Neither neither CC cord-005453-4057qib7 7504 2 a a DT cord-005453-4057qib7 7504 3 DSA DSA NNP cord-005453-4057qib7 7504 4 rebound rebound NN cord-005453-4057qib7 7504 5 nor nor CC cord-005453-4057qib7 7504 6 other other JJ cord-005453-4057qib7 7504 7 complications complication NNS cord-005453-4057qib7 7504 8 were be VBD cord-005453-4057qib7 7504 9 observed observe VBN cord-005453-4057qib7 7504 10 during during IN cord-005453-4057qib7 7504 11 the the DT cord-005453-4057qib7 7504 12 follow follow NN cord-005453-4057qib7 7504 13 - - HYPH cord-005453-4057qib7 7504 14 up up NN cord-005453-4057qib7 7504 15 . . . cord-005453-4057qib7 7505 1 Conclusions conclusion NNS cord-005453-4057qib7 7505 2 : : : cord-005453-4057qib7 7506 1 Our -PRON- PRP$ cord-005453-4057qib7 7506 2 prospective prospective JJ cord-005453-4057qib7 7506 3 analysis analysis NN cord-005453-4057qib7 7506 4 underlines underline VBZ cord-005453-4057qib7 7506 5 the the DT cord-005453-4057qib7 7506 6 high high JJ cord-005453-4057qib7 7506 7 frequency frequency NN cord-005453-4057qib7 7506 8 of of IN cord-005453-4057qib7 7506 9 anti anti JJ cord-005453-4057qib7 7506 10 - - JJ cord-005453-4057qib7 7506 11 HLA HLA NNP cord-005453-4057qib7 7506 12 antibodies antibody NNS cord-005453-4057qib7 7506 13 detection detection NN cord-005453-4057qib7 7506 14 in in IN cord-005453-4057qib7 7506 15 hematologic hematologic JJ cord-005453-4057qib7 7506 16 patients patient NNS cord-005453-4057qib7 7506 17 , , , cord-005453-4057qib7 7506 18 confirming confirm VBG cord-005453-4057qib7 7506 19 the the DT cord-005453-4057qib7 7506 20 necessity necessity NN cord-005453-4057qib7 7506 21 to to TO cord-005453-4057qib7 7506 22 routinely routinely RB cord-005453-4057qib7 7506 23 evaluate evaluate VB cord-005453-4057qib7 7506 24 the the DT cord-005453-4057qib7 7506 25 presence presence NN cord-005453-4057qib7 7506 26 of of IN cord-005453-4057qib7 7506 27 DSAs dsa NNS cord-005453-4057qib7 7506 28 before before IN cord-005453-4057qib7 7506 29 an an DT cord-005453-4057qib7 7506 30 allogeneic allogeneic NN cord-005453-4057qib7 7506 31 mismatched mismatch VBN cord-005453-4057qib7 7506 32 HSCT HSCT NNP cord-005453-4057qib7 7506 33 . . . cord-005453-4057qib7 7507 1 Our -PRON- PRP$ cord-005453-4057qib7 7507 2 desensitization desensitization NN cord-005453-4057qib7 7507 3 schedules schedule NNS cord-005453-4057qib7 7507 4 based base VBN cord-005453-4057qib7 7507 5 on on IN cord-005453-4057qib7 7507 6 the the DT cord-005453-4057qib7 7507 7 combination combination NN cord-005453-4057qib7 7507 8 of of IN cord-005453-4057qib7 7507 9 PP PP NNP cord-005453-4057qib7 7507 10 , , , cord-005453-4057qib7 7507 11 rituximab rituximab NN cord-005453-4057qib7 7507 12 , , , cord-005453-4057qib7 7507 13 IVIG IVIG NNP cord-005453-4057qib7 7507 14 and and CC cord-005453-4057qib7 7507 15 platelet platelet NN cord-005453-4057qib7 7507 16 absorption absorption NN cord-005453-4057qib7 7507 17 proved prove VBD cord-005453-4057qib7 7507 18 successful successful JJ cord-005453-4057qib7 7507 19 in in IN cord-005453-4057qib7 7507 20 reducing reduce VBG cord-005453-4057qib7 7507 21 DSAs dsa NNS cord-005453-4057qib7 7507 22 . . . cord-005453-4057qib7 7508 1 We -PRON- PRP cord-005453-4057qib7 7508 2 confirm confirm VBP cord-005453-4057qib7 7508 3 the the DT cord-005453-4057qib7 7508 4 necessity necessity NN cord-005453-4057qib7 7508 5 of of IN cord-005453-4057qib7 7508 6 a a DT cord-005453-4057qib7 7508 7 prospective prospective JJ cord-005453-4057qib7 7508 8 multicenter multicenter JJ cord-005453-4057qib7 7508 9 collaboration collaboration NN cord-005453-4057qib7 7508 10 to to TO cord-005453-4057qib7 7508 11 better better RB cord-005453-4057qib7 7508 12 define define VB cord-005453-4057qib7 7508 13 the the DT cord-005453-4057qib7 7508 14 role role NN cord-005453-4057qib7 7508 15 of of IN cord-005453-4057qib7 7508 16 DSAs dsa NNS cord-005453-4057qib7 7508 17 against against IN cord-005453-4057qib7 7508 18 each each DT cord-005453-4057qib7 7508 19 HLA HLA NNP cord-005453-4057qib7 7508 20 locus locus NN cord-005453-4057qib7 7508 21 and and CC cord-005453-4057qib7 7508 22 the the DT cord-005453-4057qib7 7508 23 critical critical JJ cord-005453-4057qib7 7508 24 MFI MFI NNP cord-005453-4057qib7 7508 25 cut cut VBN cord-005453-4057qib7 7508 26 - - HYPH cord-005453-4057qib7 7508 27 off off RP cord-005453-4057qib7 7508 28 level level NN cord-005453-4057qib7 7508 29 associated associate VBN cord-005453-4057qib7 7508 30 with with IN cord-005453-4057qib7 7508 31 a a DT cord-005453-4057qib7 7508 32 higher high JJR cord-005453-4057qib7 7508 33 risk risk NN cord-005453-4057qib7 7508 34 of of IN cord-005453-4057qib7 7508 35 GF GF NNP cord-005453-4057qib7 7508 36 . . . cord-005453-4057qib7 7509 1 Transplant transplant NN cord-005453-4057qib7 7509 2 and and CC cord-005453-4057qib7 7509 3 transfusion transfusion NN cord-005453-4057qib7 7509 4 specialists specialist NNS cord-005453-4057qib7 7509 5 should should MD cord-005453-4057qib7 7509 6 joint joint VB cord-005453-4057qib7 7509 7 to to TO cord-005453-4057qib7 7509 8 define define VB cord-005453-4057qib7 7509 9 a a DT cord-005453-4057qib7 7509 10 consensus consensus NN cord-005453-4057qib7 7509 11 for for IN cord-005453-4057qib7 7509 12 a a DT cord-005453-4057qib7 7509 13 standard standard JJ cord-005453-4057qib7 7509 14 desensitization desensitization NN cord-005453-4057qib7 7509 15 strategy strategy NN cord-005453-4057qib7 7509 16 . . . cord-005453-4057qib7 7510 1 Disclosure disclosure NN cord-005453-4057qib7 7510 2 The the DT cord-005453-4057qib7 7510 3 most most RBS cord-005453-4057qib7 7510 4 frequent frequent JJ cord-005453-4057qib7 7510 5 technique technique NN cord-005453-4057qib7 7510 6 used use VBN cord-005453-4057qib7 7510 7 for for IN cord-005453-4057qib7 7510 8 counterbalance counterbalance JJ cord-005453-4057qib7 7510 9 partial partial JJ cord-005453-4057qib7 7510 10 incompatible incompatible JJ cord-005453-4057qib7 7510 11 HSCT HSCT NNP cord-005453-4057qib7 7510 12 is be VBZ cord-005453-4057qib7 7510 13 CD34 CD34 NNP cord-005453-4057qib7 7511 1 + + CC cord-005453-4057qib7 7512 1 selection selection NN cord-005453-4057qib7 7512 2 that that WDT cord-005453-4057qib7 7512 3 is be VBZ cord-005453-4057qib7 7512 4 associated associate VBN cord-005453-4057qib7 7512 5 with with IN cord-005453-4057qib7 7512 6 sustained sustained JJ cord-005453-4057qib7 7512 7 engraftment engraftment NN cord-005453-4057qib7 7512 8 and and CC cord-005453-4057qib7 7512 9 effective effective JJ cord-005453-4057qib7 7512 10 reduction reduction NN cord-005453-4057qib7 7512 11 of of IN cord-005453-4057qib7 7512 12 T t NN cord-005453-4057qib7 7512 13 cells cell NNS cord-005453-4057qib7 7512 14 that that WDT cord-005453-4057qib7 7512 15 minimizes minimize VBZ cord-005453-4057qib7 7512 16 GvHD GvHD NNP cord-005453-4057qib7 7512 17 . . . cord-005453-4057qib7 7513 1 On on IN cord-005453-4057qib7 7513 2 the the DT cord-005453-4057qib7 7513 3 other other JJ cord-005453-4057qib7 7513 4 hand hand NN cord-005453-4057qib7 7513 5 , , , cord-005453-4057qib7 7513 6 this this DT cord-005453-4057qib7 7513 7 approach approach NN cord-005453-4057qib7 7513 8 could could MD cord-005453-4057qib7 7513 9 delay delay VB cord-005453-4057qib7 7513 10 immune immune JJ cord-005453-4057qib7 7513 11 reconstitution reconstitution NN cord-005453-4057qib7 7513 12 and and CC cord-005453-4057qib7 7513 13 increase increase VB cord-005453-4057qib7 7513 14 risk risk NN cord-005453-4057qib7 7513 15 of of IN cord-005453-4057qib7 7513 16 viral viral JJ cord-005453-4057qib7 7513 17 and and CC cord-005453-4057qib7 7513 18 fungal fungal JJ cord-005453-4057qib7 7513 19 infection infection NN cord-005453-4057qib7 7513 20 . . . cord-005453-4057qib7 7514 1 In in IN cord-005453-4057qib7 7514 2 MUD mud NN cord-005453-4057qib7 7514 3 setting set VBG cord-005453-4057qib7 7514 4 the the DT cord-005453-4057qib7 7514 5 use use NN cord-005453-4057qib7 7514 6 of of IN cord-005453-4057qib7 7514 7 PBSC PBSC NNP cord-005453-4057qib7 7514 8 is be VBZ cord-005453-4057qib7 7514 9 the the DT cord-005453-4057qib7 7514 10 procedure procedure NN cord-005453-4057qib7 7514 11 that that IN cord-005453-4057qib7 7514 12 most most JJS cord-005453-4057qib7 7514 13 centers center NNS cord-005453-4057qib7 7514 14 have have VBP cord-005453-4057qib7 7514 15 recently recently RB cord-005453-4057qib7 7514 16 adopted adopt VBN cord-005453-4057qib7 7514 17 . . . cord-005453-4057qib7 7515 1 This this DT cord-005453-4057qib7 7515 2 implies imply VBZ cord-005453-4057qib7 7515 3 the the DT cord-005453-4057qib7 7515 4 infusion infusion NN cord-005453-4057qib7 7515 5 of of IN cord-005453-4057qib7 7515 6 a a DT cord-005453-4057qib7 7515 7 relevant relevant JJ cord-005453-4057qib7 7515 8 higher high JJR cord-005453-4057qib7 7515 9 number number NN cord-005453-4057qib7 7515 10 of of IN cord-005453-4057qib7 7515 11 T t NN cord-005453-4057qib7 7515 12 cells cell NNS cord-005453-4057qib7 7515 13 5 5 CD cord-005453-4057qib7 7515 14 to to TO cord-005453-4057qib7 7515 15 10 10 CD cord-005453-4057qib7 7515 16 times time NNS cord-005453-4057qib7 7515 17 more more JJR cord-005453-4057qib7 7515 18 as as IN cord-005453-4057qib7 7515 19 compared compare VBN cord-005453-4057qib7 7515 20 with with IN cord-005453-4057qib7 7515 21 Bone Bone NNP cord-005453-4057qib7 7515 22 Marrow Marrow NNP cord-005453-4057qib7 7515 23 ( ( -LRB- cord-005453-4057qib7 7515 24 BM BM NNP cord-005453-4057qib7 7515 25 ) ) -RRB- cord-005453-4057qib7 7515 26 . . . cord-005453-4057qib7 7516 1 Since since IN cord-005453-4057qib7 7516 2 in in IN cord-005453-4057qib7 7516 3 our -PRON- PRP$ cord-005453-4057qib7 7516 4 centre centre NN cord-005453-4057qib7 7516 5 most most JJS cord-005453-4057qib7 7516 6 part part NN cord-005453-4057qib7 7516 7 of of IN cord-005453-4057qib7 7516 8 our -PRON- PRP$ cord-005453-4057qib7 7516 9 patients patient NNS cord-005453-4057qib7 7516 10 are be VBP cord-005453-4057qib7 7516 11 primary primary JJ cord-005453-4057qib7 7516 12 immunodeficiencies immunodeficiency NNS cord-005453-4057qib7 7516 13 , , , cord-005453-4057qib7 7516 14 we -PRON- PRP cord-005453-4057qib7 7516 15 applied apply VBD cord-005453-4057qib7 7516 16 a a DT cord-005453-4057qib7 7516 17 procedure procedure NN cord-005453-4057qib7 7516 18 to to TO cord-005453-4057qib7 7516 19 minimize minimize VB cord-005453-4057qib7 7516 20 the the DT cord-005453-4057qib7 7516 21 risk risk NN cord-005453-4057qib7 7516 22 of of IN cord-005453-4057qib7 7516 23 severe severe JJ cord-005453-4057qib7 7516 24 GvHD gvhd NN cord-005453-4057qib7 7516 25 infusing infuse VBG cord-005453-4057qib7 7516 26 a a DT cord-005453-4057qib7 7516 27 controlled control VBN cord-005453-4057qib7 7516 28 number number NN cord-005453-4057qib7 7516 29 of of IN cord-005453-4057qib7 7516 30 CD3 CD3 NNP cord-005453-4057qib7 7516 31 positive positive JJ cord-005453-4057qib7 7516 32 cells cell NNS cord-005453-4057qib7 7516 33 . . . cord-005453-4057qib7 7517 1 Methods method NNS cord-005453-4057qib7 7517 2 : : : cord-005453-4057qib7 7517 3 We -PRON- PRP cord-005453-4057qib7 7517 4 report report VBP cord-005453-4057qib7 7517 5 data datum NNS cord-005453-4057qib7 7517 6 about about RB cord-005453-4057qib7 7517 7 91 91 CD cord-005453-4057qib7 7517 8 paediatric paediatric JJ cord-005453-4057qib7 7517 9 patients patient NNS cord-005453-4057qib7 7517 10 who who WP cord-005453-4057qib7 7517 11 received receive VBD cord-005453-4057qib7 7517 12 92 92 CD cord-005453-4057qib7 7517 13 MUD mud NN cord-005453-4057qib7 7517 14 HSCT HSCT NNP cord-005453-4057qib7 7517 15 ( ( -LRB- cord-005453-4057qib7 7517 16 1 1 CD cord-005453-4057qib7 7517 17 patient patient NN cord-005453-4057qib7 7517 18 received receive VBD cord-005453-4057qib7 7517 19 2 2 CD cord-005453-4057qib7 7517 20 HSCT HSCT NNP cord-005453-4057qib7 7517 21 ) ) -RRB- cord-005453-4057qib7 7517 22 between between IN cord-005453-4057qib7 7517 23 2001 2001 CD cord-005453-4057qib7 7517 24 and and CC cord-005453-4057qib7 7517 25 2018 2018 CD cord-005453-4057qib7 7517 26 in in IN cord-005453-4057qib7 7517 27 the the DT cord-005453-4057qib7 7517 28 BMT BMT NNP cord-005453-4057qib7 7517 29 Unit Unit NNP cord-005453-4057qib7 7517 30 of of IN cord-005453-4057qib7 7517 31 the the DT cord-005453-4057qib7 7517 32 Children Children NNPS cord-005453-4057qib7 7517 33 's 's POS cord-005453-4057qib7 7517 34 Hospital Hospital NNP cord-005453-4057qib7 7517 35 of of IN cord-005453-4057qib7 7517 36 Brescia Brescia NNP cord-005453-4057qib7 7517 37 . . . cord-005453-4057qib7 7518 1 Patients patient NNS cord-005453-4057qib7 7518 2 received receive VBD cord-005453-4057qib7 7518 3 conditioning conditioning NN cord-005453-4057qib7 7518 4 , , , cord-005453-4057qib7 7518 5 according accord VBG cord-005453-4057qib7 7518 6 to to IN cord-005453-4057qib7 7518 7 the the DT cord-005453-4057qib7 7518 8 European European NNP cord-005453-4057qib7 7518 9 Group Group NNP cord-005453-4057qib7 7518 10 for for IN cord-005453-4057qib7 7518 11 Bone Bone NNP cord-005453-4057qib7 7518 12 Marrow Marrow NNP cord-005453-4057qib7 7518 13 Transplantation transplantation NN cord-005453-4057qib7 7518 14 ( ( -LRB- cord-005453-4057qib7 7518 15 EBMT EBMT NNP cord-005453-4057qib7 7518 16 ) ) -RRB- cord-005453-4057qib7 7518 17 and and CC cord-005453-4057qib7 7518 18 the the DT cord-005453-4057qib7 7518 19 European European NNP cord-005453-4057qib7 7518 20 Society Society NNP cord-005453-4057qib7 7518 21 for for IN cord-005453-4057qib7 7518 22 Immunodeficiencies Immunodeficiencies NNP cord-005453-4057qib7 7518 23 ( ( -LRB- cord-005453-4057qib7 7518 24 ESID ESID NNP cord-005453-4057qib7 7518 25 ) ) -RRB- cord-005453-4057qib7 7518 26 Guidelines Guidelines NNPS cord-005453-4057qib7 7518 27 . . . cord-005453-4057qib7 7519 1 CD34 CD34 NNP cord-005453-4057qib7 7519 2 + + CC cord-005453-4057qib7 7519 3 selection selection NN cord-005453-4057qib7 7519 4 has have VBZ cord-005453-4057qib7 7519 5 been be VBN cord-005453-4057qib7 7519 6 realized realize VBN cord-005453-4057qib7 7519 7 by by IN cord-005453-4057qib7 7519 8 a a DT cord-005453-4057qib7 7519 9 Milteny Milteny NNP cord-005453-4057qib7 7519 10 column column NN cord-005453-4057qib7 7519 11 with with IN cord-005453-4057qib7 7519 12 an an DT cord-005453-4057qib7 7519 13 ideal ideal JJ cord-005453-4057qib7 7519 14 addback addback NN cord-005453-4057qib7 7519 15 of of IN cord-005453-4057qib7 7519 16 CD3 CD3 NNP cord-005453-4057qib7 7519 17 positive positive JJ cord-005453-4057qib7 7519 18 cells cell NNS cord-005453-4057qib7 7519 19 of of IN cord-005453-4057qib7 7519 20 30x10 30x10 CD cord-005453-4057qib7 7519 21 6 6 CD cord-005453-4057qib7 7520 1 /Kg /Kg NNP cord-005453-4057qib7 7520 2 . . . cord-005453-4057qib7 7521 1 Stem stem JJ cord-005453-4057qib7 7521 2 cell cell NN cord-005453-4057qib7 7521 3 source source NN cord-005453-4057qib7 7521 4 was be VBD cord-005453-4057qib7 7521 5 BM BM NNP cord-005453-4057qib7 7521 6 in in IN cord-005453-4057qib7 7521 7 62 62 CD cord-005453-4057qib7 7521 8 cases case NNS cord-005453-4057qib7 7521 9 and and CC cord-005453-4057qib7 7521 10 PBSC PBSC NNP cord-005453-4057qib7 7521 11 in in IN cord-005453-4057qib7 7521 12 30 30 CD cord-005453-4057qib7 7521 13 cases case NNS cord-005453-4057qib7 7521 14 . . . cord-005453-4057qib7 7522 1 Results result NNS cord-005453-4057qib7 7522 2 : : : cord-005453-4057qib7 7523 1 Median median JJ cord-005453-4057qib7 7523 2 patients patient NNS cord-005453-4057qib7 7523 3 age age NN cord-005453-4057qib7 7523 4 at at IN cord-005453-4057qib7 7523 5 transplant transplant NN cord-005453-4057qib7 7523 6 was be VBD cord-005453-4057qib7 7523 7 2 2 CD cord-005453-4057qib7 7523 8 years year NNS cord-005453-4057qib7 7523 9 ( ( -LRB- cord-005453-4057qib7 7523 10 range range VBP cord-005453-4057qib7 7523 11 2.6 2.6 CD cord-005453-4057qib7 7523 12 months-17 months-17 CD cord-005453-4057qib7 7523 13 years year NNS cord-005453-4057qib7 7523 14 ) ) -RRB- cord-005453-4057qib7 7523 15 . . . cord-005453-4057qib7 7524 1 The the DT cord-005453-4057qib7 7524 2 mean mean JJ cord-005453-4057qib7 7524 3 number number NN cord-005453-4057qib7 7524 4 of of IN cord-005453-4057qib7 7524 5 infused infuse VBN cord-005453-4057qib7 7524 6 cells cell NNS cord-005453-4057qib7 7524 7 were be VBD cord-005453-4057qib7 7524 8 : : : cord-005453-4057qib7 7524 9 12x10 12x10 CD cord-005453-4057qib7 7524 10 6 6 CD cord-005453-4057qib7 7524 11 /Kg /kg NN cord-005453-4057qib7 7524 12 CD34 CD34 NNP cord-005453-4057qib7 7524 13 + + CC cord-005453-4057qib7 7524 14 and and CC cord-005453-4057qib7 7524 15 36x10 36x10 CD cord-005453-4057qib7 7524 16 6 6 CD cord-005453-4057qib7 7525 1 /Kg /Kg . cord-005453-4057qib7 7526 1 CD3 CD3 NNP cord-005453-4057qib7 7526 2 + + CC cord-005453-4057qib7 7526 3 in in IN cord-005453-4057qib7 7526 4 BM BM NNP cord-005453-4057qib7 7526 5 product product NN cord-005453-4057qib7 7526 6 , , , cord-005453-4057qib7 7526 7 while while IN cord-005453-4057qib7 7526 8 20x10 20x10 CD cord-005453-4057qib7 7526 9 6 6 CD cord-005453-4057qib7 7526 10 /Kg /kg NN cord-005453-4057qib7 7526 11 CD34 CD34 NNP cord-005453-4057qib7 7526 12 + + CC cord-005453-4057qib7 7526 13 and and CC cord-005453-4057qib7 7526 14 39x10 39x10 CD cord-005453-4057qib7 7526 15 6 6 CD cord-005453-4057qib7 7527 1 /Kg /Kg NNP cord-005453-4057qib7 7527 2 CD3 CD3 NNP cord-005453-4057qib7 7527 3 + + CC cord-005453-4057qib7 7527 4 in in IN cord-005453-4057qib7 7527 5 PBSC PBSC NNP cord-005453-4057qib7 7527 6 . . . cord-005453-4057qib7 7528 1 Mean mean JJ cord-005453-4057qib7 7528 2 time time NN cord-005453-4057qib7 7528 3 for for IN cord-005453-4057qib7 7528 4 engraftment engraftment NN cord-005453-4057qib7 7528 5 was be VBD cord-005453-4057qib7 7528 6 day day NN cord-005453-4057qib7 7528 7 15 15 CD cord-005453-4057qib7 7528 8 post post NN cord-005453-4057qib7 7528 9 - - JJ cord-005453-4057qib7 7528 10 HSCT HSCT NNP cord-005453-4057qib7 7528 11 . . . cord-005453-4057qib7 7529 1 As as IN cord-005453-4057qib7 7529 2 concerns concern NNS cord-005453-4057qib7 7529 3 acute acute JJ cord-005453-4057qib7 7529 4 GvHD gvhd JJ cord-005453-4057qib7 7529 5 overall overall JJ cord-005453-4057qib7 7529 6 incidence incidence NN cord-005453-4057qib7 7530 1 64.1 64.1 CD cord-005453-4057qib7 7530 2 % % NN cord-005453-4057qib7 7530 3 ( ( -LRB- cord-005453-4057qib7 7530 4 59/92 59/92 CD cord-005453-4057qib7 7530 5 ) ) -RRB- cord-005453-4057qib7 7530 6 of of IN cord-005453-4057qib7 7530 7 the the DT cord-005453-4057qib7 7530 8 children child NNS cord-005453-4057qib7 7530 9 presented present VBD cord-005453-4057qib7 7530 10 this this DT cord-005453-4057qib7 7530 11 complication complication NN cord-005453-4057qib7 7530 12 , , , cord-005453-4057qib7 7530 13 but but CC cord-005453-4057qib7 7530 14 only only RB cord-005453-4057qib7 7530 15 11 11 CD cord-005453-4057qib7 7530 16 % % NN cord-005453-4057qib7 7530 17 ( ( -LRB- cord-005453-4057qib7 7530 18 7/ 7/ CD cord-005453-4057qib7 7530 19 59 59 CD cord-005453-4057qib7 7530 20 ) ) -RRB- cord-005453-4057qib7 7530 21 presented present VBD cord-005453-4057qib7 7530 22 GvHD GvHD NNP cord-005453-4057qib7 7530 23 grade grade NN cord-005453-4057qib7 7530 24 III III NNP cord-005453-4057qib7 7530 25 and and CC cord-005453-4057qib7 7530 26 none none NN cord-005453-4057qib7 7530 27 GvHD GvHD NNP cord-005453-4057qib7 7530 28 grade grade NN cord-005453-4057qib7 7530 29 IV IV NNP cord-005453-4057qib7 7530 30 , , , cord-005453-4057qib7 7530 31 while while IN cord-005453-4057qib7 7530 32 chronic chronic JJ cord-005453-4057qib7 7530 33 GvHD GvHD NNP cord-005453-4057qib7 7530 34 presented present VBN cord-005453-4057qib7 7530 35 in in IN cord-005453-4057qib7 7530 36 7.6 7.6 CD cord-005453-4057qib7 7530 37 % % NN cord-005453-4057qib7 7530 38 ( ( -LRB- cord-005453-4057qib7 7530 39 6 6 CD cord-005453-4057qib7 7530 40 limited limited JJ cord-005453-4057qib7 7530 41 , , , cord-005453-4057qib7 7530 42 1 1 CD cord-005453-4057qib7 7530 43 extensive/92 extensive/92 NNP cord-005453-4057qib7 7530 44 ) ) -RRB- cord-005453-4057qib7 7530 45 . . . cord-005453-4057qib7 7531 1 While while IN cord-005453-4057qib7 7531 2 acute acute JJ cord-005453-4057qib7 7531 3 GvHD gvhd NN cord-005453-4057qib7 7531 4 incidence incidence NN cord-005453-4057qib7 7531 5 and and CC cord-005453-4057qib7 7531 6 severity severity NN cord-005453-4057qib7 7531 7 were be VBD cord-005453-4057qib7 7531 8 n't not RB cord-005453-4057qib7 7531 9 significantly significantly RB cord-005453-4057qib7 7531 10 different different JJ cord-005453-4057qib7 7531 11 between between IN cord-005453-4057qib7 7531 12 BM BM NNP cord-005453-4057qib7 7531 13 recipients recipient NNS cord-005453-4057qib7 7531 14 and and CC cord-005453-4057qib7 7531 15 PBSC PBSC NNP cord-005453-4057qib7 7531 16 recipients recipient NNS cord-005453-4057qib7 7531 17 , , , cord-005453-4057qib7 7531 18 the the DT cord-005453-4057qib7 7531 19 cases case NNS cord-005453-4057qib7 7531 20 of of IN cord-005453-4057qib7 7531 21 chronic chronic JJ cord-005453-4057qib7 7531 22 GvHD gvhd NN cord-005453-4057qib7 7531 23 were be VBD cord-005453-4057qib7 7531 24 prevalently prevalently RB cord-005453-4057qib7 7531 25 in in IN cord-005453-4057qib7 7531 26 the the DT cord-005453-4057qib7 7531 27 latters latter NNS cord-005453-4057qib7 7531 28 . . . cord-005453-4057qib7 7532 1 No no DT cord-005453-4057qib7 7532 2 major major JJ cord-005453-4057qib7 7532 3 infections infection NNS cord-005453-4057qib7 7532 4 presented present VBN cord-005453-4057qib7 7532 5 in in IN cord-005453-4057qib7 7532 6 the the DT cord-005453-4057qib7 7532 7 post post JJ cord-005453-4057qib7 7532 8 - - JJ cord-005453-4057qib7 7532 9 transplant transplant JJ cord-005453-4057qib7 7532 10 period period NN cord-005453-4057qib7 7532 11 and and CC cord-005453-4057qib7 7532 12 immunological immunological JJ cord-005453-4057qib7 7532 13 reconstitution reconstitution NN cord-005453-4057qib7 7532 14 both both CC cord-005453-4057qib7 7532 15 cellular cellular JJ cord-005453-4057qib7 7532 16 and and CC cord-005453-4057qib7 7532 17 humoral humoral JJ cord-005453-4057qib7 7532 18 was be VBD cord-005453-4057qib7 7532 19 completed complete VBN cord-005453-4057qib7 7532 20 by by IN cord-005453-4057qib7 7532 21 12 12 CD cord-005453-4057qib7 7532 22 months month NNS cord-005453-4057qib7 7532 23 . . . cord-005453-4057qib7 7533 1 Overall overall JJ cord-005453-4057qib7 7533 2 survival survival NN cord-005453-4057qib7 7533 3 at at IN cord-005453-4057qib7 7533 4 10 10 CD cord-005453-4057qib7 7533 5 years year NNS cord-005453-4057qib7 7533 6 is be VBZ cord-005453-4057qib7 7533 7 75 75 CD cord-005453-4057qib7 7533 8 % % NN cord-005453-4057qib7 7533 9 ( ( -LRB- cord-005453-4057qib7 7533 10 23/92 23/92 CD cord-005453-4057qib7 7533 11 ) ) -RRB- cord-005453-4057qib7 7533 12 . . . cord-005453-4057qib7 7534 1 The the DT cord-005453-4057qib7 7534 2 results result NNS cord-005453-4057qib7 7534 3 obtained obtain VBD cord-005453-4057qib7 7534 4 show show NN cord-005453-4057qib7 7534 5 how how WRB cord-005453-4057qib7 7534 6 it -PRON- PRP cord-005453-4057qib7 7534 7 is be VBZ cord-005453-4057qib7 7534 8 possible possible JJ cord-005453-4057qib7 7534 9 control control NN cord-005453-4057qib7 7534 10 severity severity NN cord-005453-4057qib7 7534 11 of of IN cord-005453-4057qib7 7534 12 GvHD GvHD NNP cord-005453-4057qib7 7534 13 if if IN cord-005453-4057qib7 7534 14 an an DT cord-005453-4057qib7 7534 15 addback addback NN cord-005453-4057qib7 7534 16 of of IN cord-005453-4057qib7 7534 17 a a DT cord-005453-4057qib7 7534 18 controlled control VBN cord-005453-4057qib7 7534 19 number number NN cord-005453-4057qib7 7534 20 of of IN cord-005453-4057qib7 7534 21 CD3 CD3 NNP cord-005453-4057qib7 7534 22 + + CC cord-005453-4057qib7 7534 23 lymphocytes lymphocyte NNS cord-005453-4057qib7 7534 24 . . . cord-005453-4057qib7 7535 1 Acute acute JJ cord-005453-4057qib7 7535 2 GvHD GvHD NNP cord-005453-4057qib7 7535 3 was be VBD cord-005453-4057qib7 7535 4 n't not RB cord-005453-4057qib7 7535 5 severe severe JJ cord-005453-4057qib7 7535 6 and and CC cord-005453-4057qib7 7535 7 only only RB cord-005453-4057qib7 7535 8 few few JJ cord-005453-4057qib7 7535 9 children child NNS cord-005453-4057qib7 7535 10 presented present VBN cord-005453-4057qib7 7535 11 with with IN cord-005453-4057qib7 7535 12 limited limited JJ cord-005453-4057qib7 7535 13 chronic chronic JJ cord-005453-4057qib7 7535 14 GvHD GvHD NNP cord-005453-4057qib7 7535 15 . . . cord-005453-4057qib7 7536 1 The the DT cord-005453-4057qib7 7536 2 method method NN cord-005453-4057qib7 7536 3 allows allow VBZ cord-005453-4057qib7 7536 4 to to TO cord-005453-4057qib7 7536 5 graft graft VB cord-005453-4057qib7 7536 6 primary primary JJ cord-005453-4057qib7 7536 7 immunodeficiencies immunodeficiency NNS cord-005453-4057qib7 7536 8 patients patient NNS cord-005453-4057qib7 7536 9 even even RB cord-005453-4057qib7 7536 10 with with IN cord-005453-4057qib7 7536 11 PBSC PBSC NNP cord-005453-4057qib7 7536 12 without without IN cord-005453-4057qib7 7536 13 infusing infuse VBG cord-005453-4057qib7 7536 14 too too RB cord-005453-4057qib7 7536 15 many many JJ cord-005453-4057qib7 7536 16 T t NN cord-005453-4057qib7 7536 17 cells cell NNS cord-005453-4057qib7 7536 18 . . . cord-005453-4057qib7 7537 1 In in IN cord-005453-4057qib7 7537 2 fact fact NN cord-005453-4057qib7 7537 3 , , , cord-005453-4057qib7 7537 4 especially especially RB cord-005453-4057qib7 7537 5 in in IN cord-005453-4057qib7 7537 6 very very RB cord-005453-4057qib7 7537 7 young young JJ cord-005453-4057qib7 7537 8 children child NNS cord-005453-4057qib7 7537 9 , , , cord-005453-4057qib7 7537 10 the the DT cord-005453-4057qib7 7537 11 number number NN cord-005453-4057qib7 7537 12 could could MD cord-005453-4057qib7 7537 13 be be VB cord-005453-4057qib7 7537 14 excessive excessive JJ cord-005453-4057qib7 7537 15 and and CC cord-005453-4057qib7 7537 16 risky risky JJ cord-005453-4057qib7 7537 17 . . . cord-005453-4057qib7 7538 1 Nevertheless nevertheless RB cord-005453-4057qib7 7538 2 in in IN cord-005453-4057qib7 7538 3 case case NN cord-005453-4057qib7 7538 4 of of IN cord-005453-4057qib7 7538 5 an an DT cord-005453-4057qib7 7538 6 oncohaematological oncohaematological JJ cord-005453-4057qib7 7538 7 patient patient NN cord-005453-4057qib7 7538 8 , , , cord-005453-4057qib7 7538 9 GvL gvl NN cord-005453-4057qib7 7538 10 effect effect NN cord-005453-4057qib7 7538 11 is be VBZ cord-005453-4057qib7 7538 12 preserved preserve VBN cord-005453-4057qib7 7538 13 . . . cord-005453-4057qib7 7539 1 Disclosure disclosure NN cord-005453-4057qib7 7539 2 Background background NN cord-005453-4057qib7 7539 3 : : : cord-005453-4057qib7 7539 4 DC DC NNP cord-005453-4057qib7 7539 5 is be VBZ cord-005453-4057qib7 7539 6 a a DT cord-005453-4057qib7 7539 7 rare rare JJ cord-005453-4057qib7 7539 8 genetic genetic JJ cord-005453-4057qib7 7539 9 disorder disorder NN cord-005453-4057qib7 7539 10 that that WDT cord-005453-4057qib7 7539 11 results result VBZ cord-005453-4057qib7 7539 12 from from IN cord-005453-4057qib7 7539 13 a a DT cord-005453-4057qib7 7539 14 defective defective JJ cord-005453-4057qib7 7539 15 telomere telomere NN cord-005453-4057qib7 7539 16 length length NN cord-005453-4057qib7 7539 17 maintenance maintenance NN cord-005453-4057qib7 7539 18 and and CC cord-005453-4057qib7 7539 19 is be VBZ cord-005453-4057qib7 7539 20 characterized characterize VBN cord-005453-4057qib7 7539 21 by by IN cord-005453-4057qib7 7539 22 mucocutaneous mucocutaneous JJ cord-005453-4057qib7 7539 23 features feature NNS cord-005453-4057qib7 7539 24 , , , cord-005453-4057qib7 7539 25 bone bone NN cord-005453-4057qib7 7539 26 marrow marrow NN cord-005453-4057qib7 7539 27 failure failure NN cord-005453-4057qib7 7539 28 ( ( -LRB- cord-005453-4057qib7 7539 29 BMF BMF NNP cord-005453-4057qib7 7539 30 ) ) -RRB- cord-005453-4057qib7 7539 31 and and CC cord-005453-4057qib7 7539 32 a a DT cord-005453-4057qib7 7539 33 high high JJ cord-005453-4057qib7 7539 34 predisposition predisposition NN cord-005453-4057qib7 7539 35 to to IN cord-005453-4057qib7 7539 36 cancer cancer NN cord-005453-4057qib7 7539 37 and and CC cord-005453-4057qib7 7539 38 pulmonary pulmonary JJ cord-005453-4057qib7 7539 39 fibrosis fibrosis NN cord-005453-4057qib7 7539 40 . . . cord-005453-4057qib7 7540 1 BMF BMF NNP cord-005453-4057qib7 7540 2 remains remain VBZ cord-005453-4057qib7 7540 3 the the DT cord-005453-4057qib7 7540 4 major major JJ cord-005453-4057qib7 7540 5 cause cause NN cord-005453-4057qib7 7540 6 of of IN cord-005453-4057qib7 7540 7 mortality mortality NN cord-005453-4057qib7 7540 8 and and CC cord-005453-4057qib7 7540 9 the the DT cord-005453-4057qib7 7540 10 HSCT HSCT NNP cord-005453-4057qib7 7540 11 is be VBZ cord-005453-4057qib7 7540 12 the the DT cord-005453-4057qib7 7540 13 only only JJ cord-005453-4057qib7 7540 14 definitive definitive JJ cord-005453-4057qib7 7540 15 treatment treatment NN cord-005453-4057qib7 7540 16 to to TO cord-005453-4057qib7 7540 17 restore restore VB cord-005453-4057qib7 7540 18 hematopoiesis hematopoiesis NN cord-005453-4057qib7 7540 19 but but CC cord-005453-4057qib7 7540 20 is be VBZ cord-005453-4057qib7 7540 21 limited limit VBN cord-005453-4057qib7 7540 22 by by IN cord-005453-4057qib7 7540 23 a a DT cord-005453-4057qib7 7540 24 high high JJ cord-005453-4057qib7 7540 25 incidence incidence NN cord-005453-4057qib7 7540 26 of of IN cord-005453-4057qib7 7540 27 treatmentrelated treatmentrelated JJ cord-005453-4057qib7 7540 28 mortality mortality NN cord-005453-4057qib7 7540 29 . . . cord-005453-4057qib7 7541 1 Methods method NNS cord-005453-4057qib7 7541 2 : : : cord-005453-4057qib7 7542 1 A a DT cord-005453-4057qib7 7542 2 retrospective retrospective JJ cord-005453-4057qib7 7542 3 analysis analysis NN cord-005453-4057qib7 7542 4 of of IN cord-005453-4057qib7 7542 5 28 28 CD cord-005453-4057qib7 7542 6 patients patient NNS cord-005453-4057qib7 7542 7 ( ( -LRB- cord-005453-4057qib7 7542 8 pts pt NNS cord-005453-4057qib7 7542 9 ) ) -RRB- cord-005453-4057qib7 7542 10 with with IN cord-005453-4057qib7 7542 11 DC DC NNP cord-005453-4057qib7 7542 12 who who WP cord-005453-4057qib7 7542 13 underwent undergo VBD cord-005453-4057qib7 7542 14 HSCT HSCT NNP cord-005453-4057qib7 7542 15 at at IN cord-005453-4057qib7 7542 16 the the DT cord-005453-4057qib7 7542 17 Bone Bone NNP cord-005453-4057qib7 7542 18 Marrow Marrow NNP cord-005453-4057qib7 7542 19 Transplantation Transplantation NNP cord-005453-4057qib7 7542 20 Unit Unit NNP cord-005453-4057qib7 7542 21 in in IN cord-005453-4057qib7 7542 22 the the DT cord-005453-4057qib7 7542 23 Clinical Clinical NNP cord-005453-4057qib7 7542 24 Hospital Hospital NNP cord-005453-4057qib7 7542 25 of of IN cord-005453-4057qib7 7542 26 Federal Federal NNP cord-005453-4057qib7 7542 27 University University NNP cord-005453-4057qib7 7542 28 of of IN cord-005453-4057qib7 7542 29 Paraná Paraná NNP cord-005453-4057qib7 7542 30 , , , cord-005453-4057qib7 7542 31 Brazil Brazil NNP cord-005453-4057qib7 7542 32 , , , cord-005453-4057qib7 7542 33 between between IN cord-005453-4057qib7 7542 34 July-1993 july-1993 XX cord-005453-4057qib7 7542 35 and and CC cord-005453-4057qib7 7542 36 November-2017 November-2017 NNP cord-005453-4057qib7 7542 37 . . . cord-005453-4057qib7 7543 1 Results result NNS cord-005453-4057qib7 7543 2 : : : cord-005453-4057qib7 7544 1 15 15 CD cord-005453-4057qib7 7544 2 boys boy NNS cord-005453-4057qib7 7544 3 and and CC cord-005453-4057qib7 7544 4 13 13 CD cord-005453-4057qib7 7544 5 girls girl NNS cord-005453-4057qib7 7544 6 , , , cord-005453-4057qib7 7544 7 with with IN cord-005453-4057qib7 7544 8 a a DT cord-005453-4057qib7 7544 9 median median JJ cord-005453-4057qib7 7544 10 age age NN cord-005453-4057qib7 7544 11 of of IN cord-005453-4057qib7 7544 12 14y 14y NNS cord-005453-4057qib7 7544 13 ( ( -LRB- cord-005453-4057qib7 7544 14 3 3 CD cord-005453-4057qib7 7544 15 -30y -30y JJS cord-005453-4057qib7 7544 16 ) ) -RRB- cord-005453-4057qib7 7544 17 received receive VBD cord-005453-4057qib7 7544 18 a a DT cord-005453-4057qib7 7544 19 HSCT HSCT NNP cord-005453-4057qib7 7544 20 from from IN cord-005453-4057qib7 7544 21 a a DT cord-005453-4057qib7 7544 22 MDS MDS NNP cord-005453-4057qib7 7544 23 ( ( -LRB- cord-005453-4057qib7 7544 24 n=7 n=7 NNS cord-005453-4057qib7 7544 25 ) ) -RRB- cord-005453-4057qib7 7544 26 , , , cord-005453-4057qib7 7544 27 MUD MUD NNP cord-005453-4057qib7 7544 28 ( ( -LRB- cord-005453-4057qib7 7544 29 n=17 n=17 NNP cord-005453-4057qib7 7544 30 ) ) -RRB- cord-005453-4057qib7 7544 31 or or CC cord-005453-4057qib7 7544 32 MMRD MMRD NNP cord-005453-4057qib7 7544 33 ( ( -LRB- cord-005453-4057qib7 7544 34 haploidentical haploidentical JJ cord-005453-4057qib7 7544 35 , , , cord-005453-4057qib7 7544 36 n=4 n=4 JJ cord-005453-4057qib7 7544 37 ) ) -RRB- cord-005453-4057qib7 7544 38 . . . cord-005453-4057qib7 7545 1 27pts 27pts NNP cord-005453-4057qib7 7545 2 received receive VBD cord-005453-4057qib7 7545 3 bone bone NN cord-005453-4057qib7 7545 4 marrow marrow NN cord-005453-4057qib7 7545 5 ( ( -LRB- cord-005453-4057qib7 7545 6 BM BM NNP cord-005453-4057qib7 7545 7 ) ) -RRB- cord-005453-4057qib7 7545 8 and and CC cord-005453-4057qib7 7545 9 1pt 1pt NNP cord-005453-4057qib7 7545 10 received receive VBD cord-005453-4057qib7 7545 11 a a DT cord-005453-4057qib7 7545 12 cord cord NN cord-005453-4057qib7 7545 13 blood blood NN cord-005453-4057qib7 7545 14 unit unit NN cord-005453-4057qib7 7545 15 ( ( -LRB- cord-005453-4057qib7 7545 16 CBU CBU NNP cord-005453-4057qib7 7545 17 ) ) -RRB- cord-005453-4057qib7 7545 18 . . . cord-005453-4057qib7 7546 1 The the DT cord-005453-4057qib7 7546 2 median median NN cord-005453-4057qib7 7546 3 of of IN cord-005453-4057qib7 7546 4 TNC TNC NNP cord-005453-4057qib7 7546 5 infused infuse VBN cord-005453-4057qib7 7546 6 was be VBD cord-005453-4057qib7 7546 7 4,76x10 4,76x10 CD cord-005453-4057qib7 7546 8 8 8 CD cord-005453-4057qib7 7547 1 /Kg /Kg . cord-005453-4057qib7 7548 1 ( ( -LRB- cord-005453-4057qib7 7548 2 range range NN cord-005453-4057qib7 7548 3 2,26 2,26 CD cord-005453-4057qib7 7548 4 - - HYPH cord-005453-4057qib7 7548 5 10,12x10 10,12x10 CD cord-005453-4057qib7 7548 6 8 8 CD cord-005453-4057qib7 7549 1 /Kg /kg LS cord-005453-4057qib7 7549 2 ) ) -RRB- cord-005453-4057qib7 7550 1 and and CC cord-005453-4057qib7 7550 2 in in IN cord-005453-4057qib7 7550 3 the the DT cord-005453-4057qib7 7550 4 CBU CBU NNP cord-005453-4057qib7 7550 5 was be VBD cord-005453-4057qib7 7550 6 6,5x10 6,5x10 NNP cord-005453-4057qib7 7550 7 7 7 CD cord-005453-4057qib7 7550 8 / / SYM cord-005453-4057qib7 7550 9 Kg Kg NNP cord-005453-4057qib7 7550 10 . . . cord-005453-4057qib7 7551 1 Two two CD cord-005453-4057qib7 7551 2 pts pt NNS cord-005453-4057qib7 7551 3 received receive VBD cord-005453-4057qib7 7551 4 a a DT cord-005453-4057qib7 7551 5 myeloablative myeloablative JJ cord-005453-4057qib7 7551 6 preparatory preparatory JJ cord-005453-4057qib7 7551 7 regimen regimen NN cord-005453-4057qib7 7551 8 with with IN cord-005453-4057qib7 7551 9 busulfan busulfan NN cord-005453-4057qib7 7551 10 ( ( -LRB- cord-005453-4057qib7 7551 11 Bu Bu NNP cord-005453-4057qib7 7551 12 ) ) -RRB- cord-005453-4057qib7 7551 13 12mg 12mg NN cord-005453-4057qib7 7551 14 / / SYM cord-005453-4057qib7 7551 15 Kg kg NN cord-005453-4057qib7 7551 16 + + CC cord-005453-4057qib7 7551 17 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 7551 18 ( ( -LRB- cord-005453-4057qib7 7551 19 Cy Cy NNP cord-005453-4057qib7 7551 20 ) ) -RRB- cord-005453-4057qib7 7551 21 120mg 120mg NNP cord-005453-4057qib7 7551 22 / / SYM cord-005453-4057qib7 7551 23 Kg Kg NNP cord-005453-4057qib7 7551 24 or or CC cord-005453-4057qib7 7551 25 fludarabine fludarabine NN cord-005453-4057qib7 7551 26 ( ( -LRB- cord-005453-4057qib7 7551 27 Flu flu NN cord-005453-4057qib7 7551 28 ) ) -RRB- cord-005453-4057qib7 7552 1 150mg 150mg NNP cord-005453-4057qib7 7552 2 / / SYM cord-005453-4057qib7 7552 3 m m NN cord-005453-4057qib7 7552 4 2 2 CD cord-005453-4057qib7 7552 5 + + SYM cord-005453-4057qib7 7552 6 antithymocyte antithymocyte NNP cord-005453-4057qib7 7552 7 globulin globulin NN cord-005453-4057qib7 7552 8 ( ( -LRB- cord-005453-4057qib7 7552 9 ATG ATG NNP cord-005453-4057qib7 7552 10 ) ) -RRB- cord-005453-4057qib7 7552 11 . . . cord-005453-4057qib7 7553 1 The the DT cord-005453-4057qib7 7553 2 remaining remain VBG cord-005453-4057qib7 7553 3 pts pt NNS cord-005453-4057qib7 7553 4 received receive VBD cord-005453-4057qib7 7553 5 a a DT cord-005453-4057qib7 7553 6 RIC RIC NNP cord-005453-4057qib7 7553 7 regimen regimen NN cord-005453-4057qib7 7553 8 with with IN cord-005453-4057qib7 7553 9 Cy200mg Cy200mg NNPS cord-005453-4057qib7 7553 10 / / SYM cord-005453-4057qib7 7553 11 Kg Kg NNP cord-005453-4057qib7 7553 12 ( ( -LRB- cord-005453-4057qib7 7553 13 n=5 n=5 NNP cord-005453-4057qib7 7553 14 ) ) -RRB- cord-005453-4057qib7 7553 15 , , , cord-005453-4057qib7 7553 16 Flu150mg Flu150mg NNP cord-005453-4057qib7 7553 17 / / SYM cord-005453-4057qib7 7553 18 m m NN cord-005453-4057qib7 7553 19 2 2 CD cord-005453-4057qib7 7554 1 + + CC cord-005453-4057qib7 7555 1 Cy60mg Cy60mg NNP cord-005453-4057qib7 7555 2 / / SYM cord-005453-4057qib7 7555 3 Kg Kg NNP cord-005453-4057qib7 7555 4 + + CC cord-005453-4057qib7 7556 1 ATG5mg ATG5mg NNP cord-005453-4057qib7 7556 2 / / SYM cord-005453-4057qib7 7556 3 Kg Kg NNP cord-005453-4057qib7 7556 4 ( ( -LRB- cord-005453-4057qib7 7556 5 n=17 n=17 NNP cord-005453-4057qib7 7556 6 ) ) -RRB- cord-005453-4057qib7 7556 7 , , , cord-005453-4057qib7 7556 8 and and CC cord-005453-4057qib7 7556 9 Flu150mg Flu150mg NNP cord-005453-4057qib7 7556 10 / / SYM cord-005453-4057qib7 7556 11 m m NN cord-005453-4057qib7 7556 12 2 2 CD cord-005453-4057qib7 7557 1 + + CC cord-005453-4057qib7 7557 2 Cy30 cy30 NN cord-005453-4057qib7 7557 3 + + CC cord-005453-4057qib7 7557 4 TBI200rads TBI200rads NNP cord-005453-4057qib7 7557 5 ( ( -LRB- cord-005453-4057qib7 7557 6 n=4 n=4 NNS cord-005453-4057qib7 7557 7 , , , cord-005453-4057qib7 7557 8 haplo haplo NNP cord-005453-4057qib7 7557 9 ) ) -RRB- cord-005453-4057qib7 7557 10 . . . cord-005453-4057qib7 7558 1 Graft graft NN cord-005453-4057qib7 7558 2 versus versus IN cord-005453-4057qib7 7558 3 Host Host NNP cord-005453-4057qib7 7558 4 Disease Disease NNP cord-005453-4057qib7 7558 5 ( ( -LRB- cord-005453-4057qib7 7558 6 GVHD GVHD NNP cord-005453-4057qib7 7558 7 ) ) -RRB- cord-005453-4057qib7 7558 8 prophylaxis prophylaxis NN cord-005453-4057qib7 7558 9 consisted consist VBD cord-005453-4057qib7 7558 10 of of IN cord-005453-4057qib7 7558 11 cyclosporin cyclosporin NN cord-005453-4057qib7 7558 12 ( ( -LRB- cord-005453-4057qib7 7558 13 CSA CSA NNP cord-005453-4057qib7 7558 14 ) ) -RRB- cord-005453-4057qib7 7558 15 and and CC cord-005453-4057qib7 7558 16 methotrexate methotrexate NNP cord-005453-4057qib7 7558 17 or or CC cord-005453-4057qib7 7558 18 steroids steroid NNS cord-005453-4057qib7 7558 19 ( ( -LRB- cord-005453-4057qib7 7558 20 CBU CBU NNP cord-005453-4057qib7 7558 21 ) ) -RRB- cord-005453-4057qib7 7558 22 and and CC cord-005453-4057qib7 7558 23 post post JJ cord-005453-4057qib7 7558 24 - - JJ cord-005453-4057qib7 7558 25 transplant transplant NN cord-005453-4057qib7 7558 26 Cy Cy NNP cord-005453-4057qib7 7558 27 + + CC cord-005453-4057qib7 7558 28 CSA CSA NNP cord-005453-4057qib7 7558 29 + + CC cord-005453-4057qib7 7558 30 mycophenolate mycophenolate NNP cord-005453-4057qib7 7558 31 mofetil mofetil NNP cord-005453-4057qib7 7558 32 in in IN cord-005453-4057qib7 7558 33 the the DT cord-005453-4057qib7 7558 34 haploidentical haploidentical JJ cord-005453-4057qib7 7558 35 transplants transplant NNS cord-005453-4057qib7 7558 36 . . . cord-005453-4057qib7 7559 1 26 26 CD cord-005453-4057qib7 7559 2 of of IN cord-005453-4057qib7 7559 3 27 27 CD cord-005453-4057qib7 7559 4 evaluable evaluable JJ cord-005453-4057qib7 7559 5 pts pt NNS cord-005453-4057qib7 7559 6 engrafted engraft VBN cord-005453-4057qib7 7559 7 with with IN cord-005453-4057qib7 7559 8 a a DT cord-005453-4057qib7 7559 9 median median JJ cord-005453-4057qib7 7559 10 time time NN cord-005453-4057qib7 7559 11 to to IN cord-005453-4057qib7 7559 12 neutrophil neutrophil NN cord-005453-4057qib7 7559 13 recovery recovery NN cord-005453-4057qib7 7559 14 of of IN cord-005453-4057qib7 7559 15 20 20 CD cord-005453-4057qib7 7559 16 days day NNS cord-005453-4057qib7 7559 17 ( ( -LRB- cord-005453-4057qib7 7559 18 range:13 range:13 NNS cord-005453-4057qib7 7559 19 - - : cord-005453-4057qib7 7559 20 36 36 CD cord-005453-4057qib7 7559 21 days day NNS cord-005453-4057qib7 7559 22 ) ) -RRB- cord-005453-4057qib7 7559 23 . . . cord-005453-4057qib7 7560 1 One one CD cord-005453-4057qib7 7560 2 patient patient NN cord-005453-4057qib7 7560 3 experienced experience VBD cord-005453-4057qib7 7560 4 primary primary JJ cord-005453-4057qib7 7560 5 graft graft NN cord-005453-4057qib7 7560 6 failure failure NN cord-005453-4057qib7 7560 7 ( ( -LRB- cord-005453-4057qib7 7560 8 haplo haplo NNP cord-005453-4057qib7 7560 9 ) ) -RRB- cord-005453-4057qib7 7560 10 while while IN cord-005453-4057qib7 7560 11 second second JJ cord-005453-4057qib7 7560 12 graft graft NN cord-005453-4057qib7 7560 13 failure failure NN cord-005453-4057qib7 7560 14 occurred occur VBD cord-005453-4057qib7 7560 15 in in IN cord-005453-4057qib7 7560 16 other other JJ cord-005453-4057qib7 7560 17 3pts 3pt NNS cord-005453-4057qib7 7560 18 . . . cord-005453-4057qib7 7561 1 All all PDT cord-005453-4057qib7 7561 2 these these DT cord-005453-4057qib7 7561 3 4pts 4pt NNS cord-005453-4057qib7 7561 4 went go VBD cord-005453-4057qib7 7561 5 a a DT cord-005453-4057qib7 7561 6 second second JJ cord-005453-4057qib7 7561 7 HSCT HSCT NNP cord-005453-4057qib7 7561 8 and and CC cord-005453-4057qib7 7561 9 3 3 CD cord-005453-4057qib7 7561 10 survived survive VBD cord-005453-4057qib7 7561 11 . . . cord-005453-4057qib7 7562 1 Acute acute JJ cord-005453-4057qib7 7562 2 GVHD GVHD NNP cord-005453-4057qib7 7562 3 grade grade NN cord-005453-4057qib7 7562 4 II II NNP cord-005453-4057qib7 7562 5 - - HYPH cord-005453-4057qib7 7562 6 IV IV NNP cord-005453-4057qib7 7562 7 occurred occur VBD cord-005453-4057qib7 7562 8 in in IN cord-005453-4057qib7 7562 9 6 6 CD cord-005453-4057qib7 7562 10 of of IN cord-005453-4057qib7 7562 11 26 26 CD cord-005453-4057qib7 7562 12 pts pt NNS cord-005453-4057qib7 7562 13 at at IN cord-005453-4057qib7 7562 14 risk risk NN cord-005453-4057qib7 7562 15 . . . cord-005453-4057qib7 7563 1 Moderate moderate JJ cord-005453-4057qib7 7563 2 to to IN cord-005453-4057qib7 7563 3 severe severe JJ cord-005453-4057qib7 7563 4 chronic chronic JJ cord-005453-4057qib7 7563 5 GVHD GVHD NNP cord-005453-4057qib7 7563 6 occurred occur VBD cord-005453-4057qib7 7563 7 in in IN cord-005453-4057qib7 7563 8 6 6 CD cord-005453-4057qib7 7563 9 pts pt NNS cord-005453-4057qib7 7563 10 with with IN cord-005453-4057qib7 7563 11 5 5 CD cord-005453-4057qib7 7563 12 cases case NNS cord-005453-4057qib7 7563 13 occurring occur VBG cord-005453-4057qib7 7563 14 in in IN cord-005453-4057qib7 7563 15 pts pts NN cord-005453-4057qib7 7563 16 who who WP cord-005453-4057qib7 7563 17 had have VBD cord-005453-4057qib7 7563 18 previously previously RB cord-005453-4057qib7 7563 19 presented present VBN cord-005453-4057qib7 7563 20 acute acute JJ cord-005453-4057qib7 7563 21 GVHD GVHD NNP cord-005453-4057qib7 7563 22 . . . cord-005453-4057qib7 7564 1 Overall overall JJ cord-005453-4057qib7 7564 2 survival survival NN cord-005453-4057qib7 7564 3 ( ( -LRB- cord-005453-4057qib7 7564 4 OS OS NNP cord-005453-4057qib7 7564 5 ) ) -RRB- cord-005453-4057qib7 7564 6 was be VBD cord-005453-4057qib7 7564 7 53,6 53,6 CD cord-005453-4057qib7 7564 8 % % NN cord-005453-4057qib7 7564 9 at at IN cord-005453-4057qib7 7564 10 a a DT cord-005453-4057qib7 7564 11 median median JJ cord-005453-4057qib7 7564 12 follow follow NN cord-005453-4057qib7 7564 13 - - HYPH cord-005453-4057qib7 7564 14 up up NN cord-005453-4057qib7 7564 15 of of IN cord-005453-4057qib7 7564 16 6y 6y CD cord-005453-4057qib7 7564 17 . . . cord-005453-4057qib7 7565 1 The the DT cord-005453-4057qib7 7565 2 5y 5y NN cord-005453-4057qib7 7565 3 OS OS NNP cord-005453-4057qib7 7565 4 was be VBD cord-005453-4057qib7 7565 5 slightly slightly RB cord-005453-4057qib7 7565 6 better well JJR cord-005453-4057qib7 7565 7 in in IN cord-005453-4057qib7 7565 8 MSD MSD NNP cord-005453-4057qib7 7565 9 transplants transplant NNS cord-005453-4057qib7 7565 10 compared compare VBN cord-005453-4057qib7 7565 11 to to IN cord-005453-4057qib7 7565 12 the the DT cord-005453-4057qib7 7565 13 others other NNS cord-005453-4057qib7 7565 14 ( ( -LRB- cord-005453-4057qib7 7565 15 54,5 54,5 CD cord-005453-4057qib7 7565 16 % % NN cord-005453-4057qib7 7566 1 x x VBP cord-005453-4057qib7 7566 2 52,9 52,9 CD cord-005453-4057qib7 7566 3 % % NN cord-005453-4057qib7 7566 4 p=0,053 p=0,053 NN cord-005453-4057qib7 7566 5 ) ) -RRB- cord-005453-4057qib7 7566 6 . . . cord-005453-4057qib7 7567 1 Causes cause NNS cord-005453-4057qib7 7567 2 of of IN cord-005453-4057qib7 7567 3 early early JJ cord-005453-4057qib7 7567 4 death death NN cord-005453-4057qib7 7567 5 include include VBP cord-005453-4057qib7 7567 6 adenovirus adenovirus NN cord-005453-4057qib7 7567 7 sepsis sepsis NN cord-005453-4057qib7 7567 8 ( ( -LRB- cord-005453-4057qib7 7567 9 n=1 n=1 NNS cord-005453-4057qib7 7567 10 ) ) -RRB- cord-005453-4057qib7 7567 11 , , , cord-005453-4057qib7 7567 12 toxicity toxicity NN cord-005453-4057qib7 7567 13 to to IN cord-005453-4057qib7 7567 14 preparatory preparatory JJ cord-005453-4057qib7 7567 15 regimen regimen NN cord-005453-4057qib7 7567 16 and and CC cord-005453-4057qib7 7567 17 sepsis sepsis NN cord-005453-4057qib7 7567 18 ( ( -LRB- cord-005453-4057qib7 7567 19 n=2 n=2 NNS cord-005453-4057qib7 7567 20 ) ) -RRB- cord-005453-4057qib7 7567 21 , , , cord-005453-4057qib7 7567 22 primary primary JJ cord-005453-4057qib7 7567 23 graft graft NN cord-005453-4057qib7 7567 24 failure failure NN cord-005453-4057qib7 7567 25 ( ( -LRB- cord-005453-4057qib7 7567 26 n=1 n=1 FW cord-005453-4057qib7 7567 27 ) ) -RRB- cord-005453-4057qib7 7567 28 . . . cord-005453-4057qib7 7568 1 13pts 13pts NNP cord-005453-4057qib7 7568 2 remain remain VBP cord-005453-4057qib7 7568 3 alive alive JJ cord-005453-4057qib7 7568 4 between between IN cord-005453-4057qib7 7568 5 1 1 CD cord-005453-4057qib7 7568 6 - - SYM cord-005453-4057qib7 7568 7 16y 16y CD cord-005453-4057qib7 7568 8 after after IN cord-005453-4057qib7 7568 9 HSCT HSCT NNP cord-005453-4057qib7 7568 10 with with IN cord-005453-4057qib7 7568 11 a a DT cord-005453-4057qib7 7568 12 median median JJ cord-005453-4057qib7 7568 13 FU FU NNP cord-005453-4057qib7 7568 14 of of IN cord-005453-4057qib7 7568 15 8y 8y CD cord-005453-4057qib7 7568 16 . . . cord-005453-4057qib7 7569 1 Among among IN cord-005453-4057qib7 7569 2 them -PRON- PRP cord-005453-4057qib7 7569 3 only only RB cord-005453-4057qib7 7569 4 1pt 1pt NNP cord-005453-4057qib7 7569 5 has have VBZ cord-005453-4057qib7 7569 6 developed develop VBN cord-005453-4057qib7 7569 7 organ organ NN cord-005453-4057qib7 7569 8 involvement involvement NN cord-005453-4057qib7 7569 9 by by IN cord-005453-4057qib7 7569 10 the the DT cord-005453-4057qib7 7569 11 underlying underlie VBG cord-005453-4057qib7 7569 12 disease disease NN cord-005453-4057qib7 7569 13 : : : cord-005453-4057qib7 7569 14 hepatopulmonary hepatopulmonary NNP cord-005453-4057qib7 7569 15 syndrome syndrome NN cord-005453-4057qib7 7569 16 ( ( -LRB- cord-005453-4057qib7 7569 17 HPS HPS NNP cord-005453-4057qib7 7569 18 ) ) -RRB- cord-005453-4057qib7 7569 19 . . . cord-005453-4057qib7 7570 1 7pts 7pts NNP cord-005453-4057qib7 7570 2 died die VBD cord-005453-4057qib7 7570 3 due due JJ cord-005453-4057qib7 7570 4 to to IN cord-005453-4057qib7 7570 5 pulmonary pulmonary JJ cord-005453-4057qib7 7570 6 fibrosis fibrosis NN cord-005453-4057qib7 7570 7 ( ( -LRB- cord-005453-4057qib7 7570 8 n=1 n=1 CD cord-005453-4057qib7 7570 9 ) ) -RRB- cord-005453-4057qib7 7570 10 , , , cord-005453-4057qib7 7570 11 liver liver NN cord-005453-4057qib7 7570 12 fibrosis(n=1 fibrosis(n=1 NNP cord-005453-4057qib7 7570 13 ) ) -RRB- cord-005453-4057qib7 7570 14 , , , cord-005453-4057qib7 7570 15 GI GI NNP cord-005453-4057qib7 7570 16 bleeding(n=1 bleeding(n=1 CD cord-005453-4057qib7 7570 17 ) ) -RRB- cord-005453-4057qib7 7570 18 , , , cord-005453-4057qib7 7570 19 HPS HPS NNP cord-005453-4057qib7 7570 20 ( ( -LRB- cord-005453-4057qib7 7570 21 n=2 n=2 NNS cord-005453-4057qib7 7570 22 ) ) -RRB- cord-005453-4057qib7 7570 23 ; ; : cord-005453-4057qib7 7570 24 cGVHD cGVHD NNP cord-005453-4057qib7 7570 25 and and CC cord-005453-4057qib7 7570 26 sepsis(n=1 sepsis(n=1 ADD cord-005453-4057qib7 7570 27 ) ) -RRB- cord-005453-4057qib7 7570 28 , , , cord-005453-4057qib7 7570 29 infection infection NN cord-005453-4057qib7 7570 30 ( ( -LRB- cord-005453-4057qib7 7570 31 n=1 n=1 CD cord-005453-4057qib7 7570 32 ) ) -RRB- cord-005453-4057qib7 7570 33 , , , cord-005453-4057qib7 7570 34 and and CC cord-005453-4057qib7 7570 35 2pts 2pts CD cord-005453-4057qib7 7570 36 were be VBD cord-005453-4057qib7 7570 37 lost lose VBN cord-005453-4057qib7 7570 38 to to IN cord-005453-4057qib7 7570 39 FU FU NNP cord-005453-4057qib7 7570 40 . . . cord-005453-4057qib7 7571 1 Conclusions conclusion NNS cord-005453-4057qib7 7571 2 : : : cord-005453-4057qib7 7572 1 Early early JJ cord-005453-4057qib7 7572 2 mortality mortality NN cord-005453-4057qib7 7572 3 from from IN cord-005453-4057qib7 7572 4 BMF BMF NNP cord-005453-4057qib7 7572 5 can can MD cord-005453-4057qib7 7572 6 be be VB cord-005453-4057qib7 7572 7 reduced reduce VBN cord-005453-4057qib7 7572 8 by by IN cord-005453-4057qib7 7572 9 HSCT HSCT NNP cord-005453-4057qib7 7572 10 , , , cord-005453-4057qib7 7572 11 but but CC cord-005453-4057qib7 7572 12 late late JJ cord-005453-4057qib7 7572 13 outcomes outcome NNS cord-005453-4057qib7 7572 14 remain remain VBP cord-005453-4057qib7 7572 15 a a DT cord-005453-4057qib7 7572 16 consequence consequence NN cord-005453-4057qib7 7572 17 of of IN cord-005453-4057qib7 7572 18 the the DT cord-005453-4057qib7 7572 19 underlying underlie VBG cord-005453-4057qib7 7572 20 disease disease NN cord-005453-4057qib7 7572 21 . . . cord-005453-4057qib7 7573 1 Long long JJ cord-005453-4057qib7 7573 2 term term NN cord-005453-4057qib7 7573 3 FU FU NNP cord-005453-4057qib7 7573 4 is be VBZ cord-005453-4057qib7 7573 5 essential essential JJ cord-005453-4057qib7 7573 6 in in IN cord-005453-4057qib7 7573 7 order order NN cord-005453-4057qib7 7573 8 to to TO cord-005453-4057qib7 7573 9 detect detect VB cord-005453-4057qib7 7573 10 late late JJ cord-005453-4057qib7 7573 11 complications complication NNS cord-005453-4057qib7 7573 12 related relate VBN cord-005453-4057qib7 7573 13 to to IN cord-005453-4057qib7 7573 14 the the DT cord-005453-4057qib7 7573 15 HSCT HSCT NNP cord-005453-4057qib7 7573 16 procedure procedure NN cord-005453-4057qib7 7573 17 or or CC cord-005453-4057qib7 7573 18 the the DT cord-005453-4057qib7 7573 19 underlying underlie VBG cord-005453-4057qib7 7573 20 disease disease NN cord-005453-4057qib7 7573 21 . . . cord-005453-4057qib7 7574 1 Disclosure disclosure NN cord-005453-4057qib7 7574 2 : : : cord-005453-4057qib7 7574 3 Nothing nothing NN cord-005453-4057qib7 7574 4 to to TO cord-005453-4057qib7 7574 5 declare declare VB cord-005453-4057qib7 7574 6 Single single JJ cord-005453-4057qib7 7574 7 intra intra JJ cord-005453-4057qib7 7574 8 - - JJ cord-005453-4057qib7 7574 9 bone bone JJ cord-005453-4057qib7 7574 10 cord cord NN cord-005453-4057qib7 7574 11 - - HYPH cord-005453-4057qib7 7574 12 blood blood NN cord-005453-4057qib7 7574 13 transplantation transplantation NN cord-005453-4057qib7 7574 14 with with IN cord-005453-4057qib7 7574 15 a a DT cord-005453-4057qib7 7574 16 treosulfan treosulfan NN cord-005453-4057qib7 7574 17 - - HYPH cord-005453-4057qib7 7574 18 based base VBN cord-005453-4057qib7 7574 19 regimen regimen NN cord-005453-4057qib7 7574 20 , , , cord-005453-4057qib7 7574 21 ATG ATG NNP cord-005453-4057qib7 7574 22 - - HYPH cord-005453-4057qib7 7574 23 free free JJ cord-005453-4057qib7 7574 24 and and CC cord-005453-4057qib7 7574 25 sirolimusbased sirolimusbase VBD cord-005453-4057qib7 7574 26 gvhd gvhd NNP cord-005453-4057qib7 7574 27 prophylaxis prophylaxis NNP cord-005453-4057qib7 7574 28 : : : cord-005453-4057qib7 7574 29 fast fast JJ cord-005453-4057qib7 7574 30 hematopoietic hematopoietic JJ cord-005453-4057qib7 7574 31 engraftment engraftment NN cord-005453-4057qib7 7574 32 and and CC cord-005453-4057qib7 7574 33 immune immune JJ cord-005453-4057qib7 7574 34 - - HYPH cord-005453-4057qib7 7574 35 reconstitution reconstitution NN cord-005453-4057qib7 7574 36 in in IN cord-005453-4057qib7 7574 37 20 20 CD cord-005453-4057qib7 7574 38 patients patient NNS cord-005453-4057qib7 7575 1 Background background NN cord-005453-4057qib7 7575 2 : : : cord-005453-4057qib7 7576 1 Cord cord NN cord-005453-4057qib7 7576 2 Blood blood NN cord-005453-4057qib7 7576 3 Transplants transplant NNS cord-005453-4057qib7 7576 4 ( ( -LRB- cord-005453-4057qib7 7576 5 CBT CBT NNP cord-005453-4057qib7 7576 6 ) ) -RRB- cord-005453-4057qib7 7576 7 require require VBP cord-005453-4057qib7 7576 8 less less RBR cord-005453-4057qib7 7576 9 stringent stringent JJ cord-005453-4057qib7 7576 10 HLA HLA NNP cord-005453-4057qib7 7576 11 - - HYPH cord-005453-4057qib7 7576 12 matching matching NN cord-005453-4057qib7 7576 13 , , , cord-005453-4057qib7 7576 14 compared compare VBN cord-005453-4057qib7 7576 15 to to IN cord-005453-4057qib7 7576 16 peripheral peripheral JJ cord-005453-4057qib7 7576 17 blood blood NN cord-005453-4057qib7 7576 18 stem stem NN cord-005453-4057qib7 7576 19 cell cell NN cord-005453-4057qib7 7576 20 or or CC cord-005453-4057qib7 7576 21 bone bone NN cord-005453-4057qib7 7576 22 marrow marrow NN cord-005453-4057qib7 7576 23 . . . cord-005453-4057qib7 7577 1 However however RB cord-005453-4057qib7 7577 2 , , , cord-005453-4057qib7 7577 3 CBT CBT NNP cord-005453-4057qib7 7577 4 has have VBZ cord-005453-4057qib7 7577 5 been be VBN cord-005453-4057qib7 7577 6 associated associate VBN cord-005453-4057qib7 7577 7 with with IN cord-005453-4057qib7 7577 8 delayed delay VBN cord-005453-4057qib7 7577 9 engraftment engraftment NN cord-005453-4057qib7 7577 10 and and CC cord-005453-4057qib7 7577 11 immune immune JJ cord-005453-4057qib7 7577 12 reconstitution reconstitution NN cord-005453-4057qib7 7577 13 , , , cord-005453-4057qib7 7577 14 especially especially RB cord-005453-4057qib7 7577 15 if if IN cord-005453-4057qib7 7577 16 in in IN cord-005453-4057qib7 7577 17 vivo vivo NNP cord-005453-4057qib7 7577 18 T t NN cord-005453-4057qib7 7577 19 - - HYPH cord-005453-4057qib7 7577 20 cell cell NN cord-005453-4057qib7 7577 21 depletion depletion NN cord-005453-4057qib7 7577 22 , , , cord-005453-4057qib7 7577 23 such such JJ cord-005453-4057qib7 7577 24 as as IN cord-005453-4057qib7 7577 25 antithymoglobulin antithymoglobulin NNP cord-005453-4057qib7 7577 26 ( ( -LRB- cord-005453-4057qib7 7577 27 ATG ATG NNP cord-005453-4057qib7 7577 28 ) ) -RRB- cord-005453-4057qib7 7577 29 , , , cord-005453-4057qib7 7577 30 is be VBZ cord-005453-4057qib7 7577 31 used use VBN cord-005453-4057qib7 7577 32 . . . cord-005453-4057qib7 7578 1 Methods method NNS cord-005453-4057qib7 7578 2 : : : cord-005453-4057qib7 7579 1 From from IN cord-005453-4057qib7 7579 2 2010 2010 CD cord-005453-4057qib7 7579 3 to to IN cord-005453-4057qib7 7579 4 2018 2018 CD cord-005453-4057qib7 7579 5 , , , cord-005453-4057qib7 7579 6 20 20 CD cord-005453-4057qib7 7579 7 patients patient NNS cord-005453-4057qib7 7579 8 with with IN cord-005453-4057qib7 7579 9 high high JJ cord-005453-4057qib7 7579 10 - - HYPH cord-005453-4057qib7 7579 11 risk risk NN cord-005453-4057qib7 7579 12 diseases disease NNS cord-005453-4057qib7 7579 13 received receive VBD cord-005453-4057qib7 7579 14 intra intra JJ cord-005453-4057qib7 7579 15 - - JJ cord-005453-4057qib7 7579 16 bone bone JJ cord-005453-4057qib7 7579 17 infusion infusion NN cord-005453-4057qib7 7579 18 of of IN cord-005453-4057qib7 7579 19 unwashed unwashed JJ cord-005453-4057qib7 7579 20 single single JJ cord-005453-4057qib7 7579 21 CB CB NNP cord-005453-4057qib7 7579 22 unit unit NN cord-005453-4057qib7 7579 23 with with IN cord-005453-4057qib7 7579 24 an an DT cord-005453-4057qib7 7579 25 ATG ATG NNP cord-005453-4057qib7 7579 26 - - HYPH cord-005453-4057qib7 7579 27 free free JJ cord-005453-4057qib7 7579 28 GvHD GvHD NNP cord-005453-4057qib7 7579 29 prophylaxis prophylaxis NN cord-005453-4057qib7 7579 30 ; ; : cord-005453-4057qib7 7579 31 7 7 CD cord-005453-4057qib7 7579 32 were be VBD cord-005453-4057qib7 7579 33 in in IN cord-005453-4057qib7 7579 34 active active JJ cord-005453-4057qib7 7579 35 disease disease NN cord-005453-4057qib7 7579 36 at at IN cord-005453-4057qib7 7579 37 CBT CBT NNP cord-005453-4057qib7 7579 38 and and CC cord-005453-4057qib7 7579 39 8 8 CD cord-005453-4057qib7 7579 40 had have VBD cord-005453-4057qib7 7579 41 received receive VBN cord-005453-4057qib7 7579 42 prior prior JJ cord-005453-4057qib7 7579 43 allogeneic allogeneic NN cord-005453-4057qib7 7579 44 stem stem NN cord-005453-4057qib7 7579 45 cell cell NN cord-005453-4057qib7 7579 46 transplantation transplantation NN cord-005453-4057qib7 7579 47 . . . cord-005453-4057qib7 7580 1 Median median JJ cord-005453-4057qib7 7580 2 age age NN cord-005453-4057qib7 7580 3 was be VBD cord-005453-4057qib7 7580 4 44 44 CD cord-005453-4057qib7 7580 5 y y NN cord-005453-4057qib7 7580 6 [ [ -LRB- cord-005453-4057qib7 7580 7 range range NN cord-005453-4057qib7 7580 8 ( ( -LRB- cord-005453-4057qib7 7580 9 r r NN cord-005453-4057qib7 7580 10 ) ) -RRB- cord-005453-4057qib7 7580 11 . . . cord-005453-4057qib7 7581 1 Conditioning conditioning NN cord-005453-4057qib7 7581 2 regimen regimen NN cord-005453-4057qib7 7581 3 was be VBD cord-005453-4057qib7 7581 4 myeloablative myeloablative JJ cord-005453-4057qib7 7581 5 , , , cord-005453-4057qib7 7581 6 with with IN cord-005453-4057qib7 7581 7 Treosulfan Treosulfan NNP cord-005453-4057qib7 7581 8 and and CC cord-005453-4057qib7 7581 9 Fludarabine Fludarabine NNP cord-005453-4057qib7 7581 10 in in IN cord-005453-4057qib7 7581 11 all all DT cord-005453-4057qib7 7581 12 , , , cord-005453-4057qib7 7581 13 intensified intensify VBN cord-005453-4057qib7 7581 14 with with IN cord-005453-4057qib7 7581 15 Melphalan Melphalan NNP cord-005453-4057qib7 7581 16 in in IN cord-005453-4057qib7 7581 17 15 15 CD cord-005453-4057qib7 7581 18 or or CC cord-005453-4057qib7 7581 19 with with IN cord-005453-4057qib7 7581 20 4Gy 4gy JJ cord-005453-4057qib7 7581 21 TBI TBI NNP cord-005453-4057qib7 7581 22 in in IN cord-005453-4057qib7 7581 23 4 4 CD cord-005453-4057qib7 7581 24 . . . cord-005453-4057qib7 7582 1 HLA HLA NNP cord-005453-4057qib7 7582 2 matches match NNS cord-005453-4057qib7 7582 3 was be VBD cord-005453-4057qib7 7582 4 4/6 4/6 CD cord-005453-4057qib7 7582 5 , , , cord-005453-4057qib7 7582 6 5/6 5/6 CD cord-005453-4057qib7 7582 7 , , , cord-005453-4057qib7 7582 8 6/6 6/6 CD cord-005453-4057qib7 7582 9 in in IN cord-005453-4057qib7 7582 10 12 12 CD cord-005453-4057qib7 7582 11 , , , cord-005453-4057qib7 7582 12 5 5 CD cord-005453-4057qib7 7582 13 and and CC cord-005453-4057qib7 7582 14 3 3 CD cord-005453-4057qib7 7582 15 cases case NNS cord-005453-4057qib7 7582 16 , , , cord-005453-4057qib7 7582 17 respectively respectively RB cord-005453-4057qib7 7582 18 . . . cord-005453-4057qib7 7583 1 GvHD GvHD NNP cord-005453-4057qib7 7583 2 prophylaxis prophylaxis NN cord-005453-4057qib7 7583 3 included include VBD cord-005453-4057qib7 7583 4 Sirolimus Sirolimus NNP cord-005453-4057qib7 7583 5 and and CC cord-005453-4057qib7 7583 6 Mycophenolic Mycophenolic NNP cord-005453-4057qib7 7583 7 acid acid NN cord-005453-4057qib7 7583 8 ( ( -LRB- cord-005453-4057qib7 7583 9 MMF MMF NNP cord-005453-4057qib7 7583 10 ) ) -RRB- cord-005453-4057qib7 7583 11 . . . cord-005453-4057qib7 7584 1 Results result NNS cord-005453-4057qib7 7584 2 : : : cord-005453-4057qib7 7585 1 After after IN cord-005453-4057qib7 7585 2 thawing thawing NN cord-005453-4057qib7 7585 3 , , , cord-005453-4057qib7 7585 4 median median JJ cord-005453-4057qib7 7585 5 CD45 CD45 NNP cord-005453-4057qib7 7585 6 + + CC cord-005453-4057qib7 7585 7 cells cell NNS cord-005453-4057qib7 7585 8 was be VBD cord-005453-4057qib7 7585 9 1.39 1.39 CD cord-005453-4057qib7 7585 10 x x SYM cord-005453-4057qib7 7585 11 10 10 CD cord-005453-4057qib7 7585 12 7 7 CD cord-005453-4057qib7 7586 1 /kg /kg . cord-005453-4057qib7 7587 1 [ [ -LRB- cord-005453-4057qib7 7587 2 r r NN cord-005453-4057qib7 7587 3 0.69 0.69 CD cord-005453-4057qib7 7587 4 - - SYM cord-005453-4057qib7 7587 5 5.9 5.9 CD cord-005453-4057qib7 7587 6 ] ] -RRB- cord-005453-4057qib7 7587 7 , , , cord-005453-4057qib7 7587 8 median median JJ cord-005453-4057qib7 7587 9 CD34 CD34 NNP cord-005453-4057qib7 7587 10 + + CC cord-005453-4057qib7 7587 11 cells cell NNS cord-005453-4057qib7 7587 12 0.08 0.08 CD cord-005453-4057qib7 7587 13 x x SYM cord-005453-4057qib7 7587 14 10 10 CD cord-005453-4057qib7 7587 15 6 6 CD cord-005453-4057qib7 7588 1 /kg /kg . cord-005453-4057qib7 7589 1 [ [ -LRB- cord-005453-4057qib7 7589 2 r r NN cord-005453-4057qib7 7589 3 0.04 0.04 CD cord-005453-4057qib7 7589 4 - - SYM cord-005453-4057qib7 7589 5 0.23 0.23 CD cord-005453-4057qib7 7589 6 ] ] -RRB- cord-005453-4057qib7 7589 7 , , , cord-005453-4057qib7 7589 8 and and CC cord-005453-4057qib7 7589 9 median median NN cord-005453-4057qib7 7589 10 CD3 cd3 NN cord-005453-4057qib7 7590 1 + + CC cord-005453-4057qib7 7590 2 cells cell NNS cord-005453-4057qib7 7590 3 3.05 3.05 CD cord-005453-4057qib7 7590 4 x x SYM cord-005453-4057qib7 7590 5 10 10 CD cord-005453-4057qib7 7590 6 6 6 CD cord-005453-4057qib7 7591 1 /kg /kg . cord-005453-4057qib7 7592 1 [ [ -LRB- cord-005453-4057qib7 7592 2 r r NN cord-005453-4057qib7 7592 3 1.29 1.29 CD cord-005453-4057qib7 7592 4 - - SYM cord-005453-4057qib7 7592 5 5.9 5.9 CD cord-005453-4057qib7 7592 6 ] ] -RRB- cord-005453-4057qib7 7592 7 . . . cord-005453-4057qib7 7593 1 Of of IN cord-005453-4057qib7 7593 2 the the DT cord-005453-4057qib7 7593 3 16 16 CD cord-005453-4057qib7 7593 4 evaluable evaluable JJ cord-005453-4057qib7 7593 5 patients patient NNS cord-005453-4057qib7 7593 6 all all DT cord-005453-4057qib7 7593 7 engrafted engraft VBD cord-005453-4057qib7 7593 8 with with IN cord-005453-4057qib7 7593 9 a a DT cord-005453-4057qib7 7593 10 sustained sustained JJ cord-005453-4057qib7 7593 11 full full JJ cord-005453-4057qib7 7593 12 donor donor NN cord-005453-4057qib7 7593 13 chimerism chimerism NN cord-005453-4057qib7 7593 14 at at IN cord-005453-4057qib7 7593 15 day day NN cord-005453-4057qib7 7593 16 100 100 CD cord-005453-4057qib7 7593 17 . . . cord-005453-4057qib7 7594 1 Median median JJ cord-005453-4057qib7 7594 2 time time NN cord-005453-4057qib7 7594 3 to to IN cord-005453-4057qib7 7594 4 neutrophils neutrophil NNS cord-005453-4057qib7 7594 5 ( ( -LRB- cord-005453-4057qib7 7594 6 16/16 16/16 CD cord-005453-4057qib7 7594 7 , , , cord-005453-4057qib7 7594 8 ANC ANC NNP cord-005453-4057qib7 7594 9 > > XX cord-005453-4057qib7 7595 1 500 500 CD cord-005453-4057qib7 7595 2 / / SYM cord-005453-4057qib7 7595 3 μL μL . cord-005453-4057qib7 7596 1 for for IN cord-005453-4057qib7 7596 2 3 3 CD cord-005453-4057qib7 7596 3 consecutive consecutive JJ cord-005453-4057qib7 7596 4 days day NNS cord-005453-4057qib7 7596 5 ) ) -RRB- cord-005453-4057qib7 7596 6 and and CC cord-005453-4057qib7 7596 7 platelet platelet NN cord-005453-4057qib7 7596 8 engraftment engraftment NN cord-005453-4057qib7 7596 9 ( ( -LRB- cord-005453-4057qib7 7596 10 14/ 14/ CD cord-005453-4057qib7 7596 11 Immune immune NN cord-005453-4057qib7 7596 12 - - HYPH cord-005453-4057qib7 7596 13 reconstitution reconstitution NN cord-005453-4057qib7 7596 14 of of IN cord-005453-4057qib7 7596 15 CBT CBT NNP cord-005453-4057qib7 7596 16 patients patient NNS cord-005453-4057qib7 7596 17 ( ( -LRB- cord-005453-4057qib7 7596 18 Tables table NNS cord-005453-4057qib7 7596 19 1a 1a NNP cord-005453-4057qib7 7596 20 - - HYPH cord-005453-4057qib7 7596 21 b b LS cord-005453-4057qib7 7596 22 ) ) -RRB- cord-005453-4057qib7 7596 23 was be VBD cord-005453-4057qib7 7596 24 compared compare VBN cord-005453-4057qib7 7596 25 with with IN cord-005453-4057qib7 7596 26 two two CD cord-005453-4057qib7 7596 27 cohorts cohort NNS cord-005453-4057qib7 7596 28 of of IN cord-005453-4057qib7 7596 29 patients patient NNS cord-005453-4057qib7 7596 30 transplanted transplant VBN cord-005453-4057qib7 7596 31 at at IN cord-005453-4057qib7 7596 32 our -PRON- PRP$ cord-005453-4057qib7 7596 33 Center Center NNP cord-005453-4057qib7 7596 34 from from IN cord-005453-4057qib7 7596 35 any any DT cord-005453-4057qib7 7596 36 adult adult NN cord-005453-4057qib7 7596 37 donor donor NN cord-005453-4057qib7 7596 38 with with IN cord-005453-4057qib7 7596 39 ( ( -LRB- cord-005453-4057qib7 7596 40 81 81 CD cord-005453-4057qib7 7596 41 ) ) -RRB- cord-005453-4057qib7 7596 42 or or CC cord-005453-4057qib7 7596 43 without without IN cord-005453-4057qib7 7596 44 ( ( -LRB- cord-005453-4057qib7 7596 45 126 126 CD cord-005453-4057qib7 7596 46 patients patient NNS cord-005453-4057qib7 7596 47 , , , cord-005453-4057qib7 7596 48 including include VBG cord-005453-4057qib7 7596 49 post post JJ cord-005453-4057qib7 7596 50 - - JJ cord-005453-4057qib7 7596 51 transplant transplant NN cord-005453-4057qib7 7596 52 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 7596 53 cohort cohort NN cord-005453-4057qib7 7596 54 ) ) -RRB- cord-005453-4057qib7 7596 55 ATG ATG NNP cord-005453-4057qib7 7596 56 in in IN cord-005453-4057qib7 7596 57 association association NN cord-005453-4057qib7 7596 58 with with IN cord-005453-4057qib7 7596 59 Sirolimus Sirolimus NNP cord-005453-4057qib7 7596 60 and and CC cord-005453-4057qib7 7596 61 MMF MMF NNP cord-005453-4057qib7 7596 62 . . . cord-005453-4057qib7 7597 1 Profiles profile NNS cord-005453-4057qib7 7597 2 of of IN cord-005453-4057qib7 7597 3 immune immune JJ cord-005453-4057qib7 7597 4 - - HYPH cord-005453-4057qib7 7597 5 reconstitution reconstitution NN cord-005453-4057qib7 7597 6 at at IN cord-005453-4057qib7 7597 7 day day NN cord-005453-4057qib7 7597 8 90 90 CD cord-005453-4057qib7 7598 1 -180 -180 NNP cord-005453-4057qib7 7599 1 -365 -365 NNP cord-005453-4057qib7 7599 2 showed show VBD cord-005453-4057qib7 7599 3 a a DT cord-005453-4057qib7 7599 4 better well JJR cord-005453-4057qib7 7599 5 CD4 CD4 NNP cord-005453-4057qib7 7599 6 + + CC cord-005453-4057qib7 7599 7 recovery recovery NN cord-005453-4057qib7 7599 8 at at IN cord-005453-4057qib7 7599 9 any any DT cord-005453-4057qib7 7599 10 time time NN cord-005453-4057qib7 7599 11 - - HYPH cord-005453-4057qib7 7599 12 point point NN cord-005453-4057qib7 7599 13 in in IN cord-005453-4057qib7 7599 14 both both CC cord-005453-4057qib7 7599 15 CBT CBT NNP cord-005453-4057qib7 7599 16 and and CC cord-005453-4057qib7 7599 17 no no DT cord-005453-4057qib7 7599 18 - - HYPH cord-005453-4057qib7 7599 19 ATG ATG NNP cord-005453-4057qib7 7599 20 versus versus IN cord-005453-4057qib7 7599 21 ATG ATG NNP cord-005453-4057qib7 7599 22 cohort cohort NN cord-005453-4057qib7 7599 23 , , , cord-005453-4057qib7 7599 24 with with IN cord-005453-4057qib7 7599 25 no no DT cord-005453-4057qib7 7599 26 statistic statistic JJ cord-005453-4057qib7 7599 27 significant significant JJ cord-005453-4057qib7 7599 28 difference difference NN cord-005453-4057qib7 7599 29 in in IN cord-005453-4057qib7 7599 30 the the DT cord-005453-4057qib7 7599 31 first first JJ cord-005453-4057qib7 7599 32 2 2 CD cord-005453-4057qib7 7599 33 cohorts cohort NNS cord-005453-4057qib7 7599 34 . . . cord-005453-4057qib7 7600 1 Moreover moreover RB cord-005453-4057qib7 7600 2 , , , cord-005453-4057qib7 7600 3 CD4 CD4 NNP cord-005453-4057qib7 7600 4 + + CC cord-005453-4057qib7 7600 5 /CD8 /CD8 , cord-005453-4057qib7 7600 6 + + CC cord-005453-4057qib7 7600 7 ratio ratio NN cord-005453-4057qib7 7600 8 at at IN cord-005453-4057qib7 7600 9 any any DT cord-005453-4057qib7 7600 10 time time NN cord-005453-4057qib7 7600 11 point point NN cord-005453-4057qib7 7600 12 was be VBD cord-005453-4057qib7 7600 13 better well JJR cord-005453-4057qib7 7600 14 in in IN cord-005453-4057qib7 7600 15 the the DT cord-005453-4057qib7 7600 16 CBT CBT NNP cord-005453-4057qib7 7600 17 cohort cohort NN cord-005453-4057qib7 7600 18 vs vs IN cord-005453-4057qib7 7600 19 the the DT cord-005453-4057qib7 7600 20 no no DT cord-005453-4057qib7 7600 21 - - HYPH cord-005453-4057qib7 7600 22 ATG ATG NNP cord-005453-4057qib7 7600 23 cohort cohort NN cord-005453-4057qib7 7600 24 . . . cord-005453-4057qib7 7601 1 B b NN cord-005453-4057qib7 7601 2 cell cell NN cord-005453-4057qib7 7601 3 recovery recovery NN cord-005453-4057qib7 7601 4 was be VBD cord-005453-4057qib7 7601 5 faster fast JJR cord-005453-4057qib7 7601 6 in in IN cord-005453-4057qib7 7601 7 the the DT cord-005453-4057qib7 7601 8 CBT CBT NNP cord-005453-4057qib7 7601 9 cohort cohort NN cord-005453-4057qib7 7601 10 ; ; : cord-005453-4057qib7 7601 11 immunoglobulin immunoglobulin NN cord-005453-4057qib7 7601 12 recovery recovery NN cord-005453-4057qib7 7601 13 was be VBD cord-005453-4057qib7 7601 14 superimposable superimposable JJ cord-005453-4057qib7 7601 15 across across IN cord-005453-4057qib7 7601 16 different different JJ cord-005453-4057qib7 7601 17 platforms platform NNS cord-005453-4057qib7 7601 18 . . . cord-005453-4057qib7 7602 1 Focusing focus VBG cord-005453-4057qib7 7602 2 on on IN cord-005453-4057qib7 7602 3 late late JJ cord-005453-4057qib7 7602 4 events event NNS cord-005453-4057qib7 7602 5 ( ( -LRB- cord-005453-4057qib7 7602 6 > > NFP cord-005453-4057qib7 7602 7 180 180 CD cord-005453-4057qib7 7602 8 days day NNS cord-005453-4057qib7 7602 9 from from IN cord-005453-4057qib7 7602 10 CBT CBT NNP cord-005453-4057qib7 7602 11 ) ) -RRB- cord-005453-4057qib7 7602 12 , , , cord-005453-4057qib7 7602 13 3/12 3/12 CD cord-005453-4057qib7 7602 14 pts pts NN cord-005453-4057qib7 7602 15 experienced experience VBN cord-005453-4057qib7 7602 16 EBV EBV NNP cord-005453-4057qib7 7602 17 reactivation reactivation NN cord-005453-4057qib7 7602 18 , , , cord-005453-4057qib7 7602 19 median median JJ cord-005453-4057qib7 7602 20 time time NN cord-005453-4057qib7 7602 21 586 586 CD cord-005453-4057qib7 7602 22 days day NNS cord-005453-4057qib7 7602 23 [ [ -LRB- cord-005453-4057qib7 7602 24 362 362 CD cord-005453-4057qib7 7602 25 - - SYM cord-005453-4057qib7 7602 26 655 655 CD cord-005453-4057qib7 7602 27 ] ] -RRB- cord-005453-4057qib7 7602 28 treated treat VBN cord-005453-4057qib7 7602 29 with with IN cord-005453-4057qib7 7602 30 rituximab rituximab NN cord-005453-4057qib7 7602 31 , , , cord-005453-4057qib7 7602 32 and and CC cord-005453-4057qib7 7602 33 1 1 CD cord-005453-4057qib7 7602 34 experienced experience VBD cord-005453-4057qib7 7602 35 late late JJ cord-005453-4057qib7 7602 36 HHV6 HHV6 NNP cord-005453-4057qib7 7602 37 and and CC cord-005453-4057qib7 7602 38 CMV CMV NNP cord-005453-4057qib7 7602 39 reactivation reactivation NN cord-005453-4057qib7 7602 40 , , , cord-005453-4057qib7 7602 41 both both DT cord-005453-4057qib7 7602 42 solved solve VBD cord-005453-4057qib7 7602 43 at at IN cord-005453-4057qib7 7602 44 last last JJ cord-005453-4057qib7 7602 45 visit visit NN cord-005453-4057qib7 7602 46 . . . cord-005453-4057qib7 7603 1 Sirolimus Sirolimus NNP cord-005453-4057qib7 7603 2 was be VBD cord-005453-4057qib7 7603 3 withdrawn withdraw VBN cord-005453-4057qib7 7603 4 after after IN cord-005453-4057qib7 7603 5 a a DT cord-005453-4057qib7 7603 6 median median NN cord-005453-4057qib7 7603 7 of of IN cord-005453-4057qib7 7603 8 188 188 CD cord-005453-4057qib7 7603 9 days day NNS cord-005453-4057qib7 7604 1 [ [ -LRB- cord-005453-4057qib7 7604 2 r r NNP cord-005453-4057qib7 7604 3 64 64 CD cord-005453-4057qib7 7604 4 - - SYM cord-005453-4057qib7 7604 5 394 394 CD cord-005453-4057qib7 7604 6 ] ] -RRB- cord-005453-4057qib7 7604 7 . . . cord-005453-4057qib7 7605 1 Only only RB cord-005453-4057qib7 7605 2 1 1 CD cord-005453-4057qib7 7605 3 patient patient NN cord-005453-4057qib7 7605 4 developed develop VBD cord-005453-4057qib7 7605 5 severe severe JJ cord-005453-4057qib7 7605 6 chronic chronic JJ cord-005453-4057qib7 7605 7 GvHD GvHD NNP cord-005453-4057qib7 7605 8 , , , cord-005453-4057qib7 7605 9 solved solve VBD cord-005453-4057qib7 7605 10 at at IN cord-005453-4057qib7 7605 11 last last JJ cord-005453-4057qib7 7605 12 visit visit NN cord-005453-4057qib7 7605 13 . . . cord-005453-4057qib7 7606 1 Overall overall RB cord-005453-4057qib7 7606 2 , , , cord-005453-4057qib7 7606 3 after after IN cord-005453-4057qib7 7606 4 a a DT cord-005453-4057qib7 7606 5 median median JJ cord-005453-4057qib7 7606 6 follow follow NN cord-005453-4057qib7 7606 7 - - HYPH cord-005453-4057qib7 7606 8 up up NN cord-005453-4057qib7 7606 9 of of IN cord-005453-4057qib7 7606 10 330 330 CD cord-005453-4057qib7 7606 11 days day NNS cord-005453-4057qib7 7606 12 [ [ -LRB- cord-005453-4057qib7 7606 13 r r NNP cord-005453-4057qib7 7606 14 9 9 CD cord-005453-4057qib7 7606 15 - - SYM cord-005453-4057qib7 7606 16 1311 1311 CD cord-005453-4057qib7 7606 17 ] ] -RRB- cord-005453-4057qib7 7606 18 , , , cord-005453-4057qib7 7606 19 11 11 CD cord-005453-4057qib7 7606 20 pts pt NNS cord-005453-4057qib7 7606 21 are be VBP cord-005453-4057qib7 7606 22 alive alive JJ cord-005453-4057qib7 7606 23 and and CC cord-005453-4057qib7 7606 24 well well RB cord-005453-4057qib7 7606 25 . . . cord-005453-4057qib7 7607 1 Conclusions conclusion NNS cord-005453-4057qib7 7607 2 : : : cord-005453-4057qib7 7608 1 Our -PRON- PRP$ cord-005453-4057qib7 7608 2 data datum NNS cord-005453-4057qib7 7608 3 confirm confirm VBP cord-005453-4057qib7 7608 4 that that IN cord-005453-4057qib7 7608 5 intra intra JJ cord-005453-4057qib7 7608 6 - - JJ cord-005453-4057qib7 7608 7 bone bone JJ cord-005453-4057qib7 7608 8 CBT CBT NNP cord-005453-4057qib7 7608 9 without without IN cord-005453-4057qib7 7608 10 in in IN cord-005453-4057qib7 7608 11 - - HYPH cord-005453-4057qib7 7608 12 vivo vivo NN cord-005453-4057qib7 7608 13 T t NN cord-005453-4057qib7 7608 14 - - HYPH cord-005453-4057qib7 7608 15 cell cell NN cord-005453-4057qib7 7608 16 depletion depletion NN cord-005453-4057qib7 7608 17 is be VBZ cord-005453-4057qib7 7608 18 associated associate VBN cord-005453-4057qib7 7608 19 with with IN cord-005453-4057qib7 7608 20 fast fast JJ cord-005453-4057qib7 7608 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 7608 22 engraftment engraftment NN cord-005453-4057qib7 7608 23 and and CC cord-005453-4057qib7 7608 24 immune immune JJ cord-005453-4057qib7 7608 25 - - HYPH cord-005453-4057qib7 7608 26 reconstitution reconstitution NN cord-005453-4057qib7 7608 27 , , , cord-005453-4057qib7 7608 28 with with IN cord-005453-4057qib7 7608 29 very very RB cord-005453-4057qib7 7608 30 low low JJ cord-005453-4057qib7 7608 31 rate rate NN cord-005453-4057qib7 7608 32 of of IN cord-005453-4057qib7 7608 33 chronic chronic JJ cord-005453-4057qib7 7608 34 GvHD gvhd NN cord-005453-4057qib7 7608 35 and and CC cord-005453-4057qib7 7608 36 late late JJ cord-005453-4057qib7 7608 37 infective infective JJ cord-005453-4057qib7 7608 38 events event NNS cord-005453-4057qib7 7608 39 . . . cord-005453-4057qib7 7609 1 Background background NN cord-005453-4057qib7 7609 2 : : : cord-005453-4057qib7 7610 1 A a DT cord-005453-4057qib7 7610 2 promising promising JJ cord-005453-4057qib7 7610 3 improvement improvement NN cord-005453-4057qib7 7610 4 of of IN cord-005453-4057qib7 7610 5 hematopoietic hematopoietic JJ cord-005453-4057qib7 7610 6 stem stem NN cord-005453-4057qib7 7610 7 cell cell NN cord-005453-4057qib7 7610 8 transplantation transplantation NN cord-005453-4057qib7 7610 9 ( ( -LRB- cord-005453-4057qib7 7610 10 HSCT HSCT NNP cord-005453-4057qib7 7610 11 ) ) -RRB- cord-005453-4057qib7 7610 12 may may MD cord-005453-4057qib7 7610 13 lie lie VB cord-005453-4057qib7 7610 14 in in IN cord-005453-4057qib7 7610 15 the the DT cord-005453-4057qib7 7610 16 transplantation transplantation NN cord-005453-4057qib7 7610 17 of of IN cord-005453-4057qib7 7610 18 high high JJ cord-005453-4057qib7 7610 19 numbers number NNS cord-005453-4057qib7 7610 20 of of IN cord-005453-4057qib7 7610 21 pluripotent pluripotent JJ cord-005453-4057qib7 7610 22 stem stem NN cord-005453-4057qib7 7610 23 cells cell NNS cord-005453-4057qib7 7610 24 to to TO cord-005453-4057qib7 7610 25 minimize minimize VB cord-005453-4057qib7 7610 26 the the DT cord-005453-4057qib7 7610 27 time time NN cord-005453-4057qib7 7610 28 span span NN cord-005453-4057qib7 7610 29 between between IN cord-005453-4057qib7 7610 30 transplantation transplantation NN cord-005453-4057qib7 7610 31 and and CC cord-005453-4057qib7 7610 32 immunological immunological JJ cord-005453-4057qib7 7610 33 reconstitution reconstitution NN cord-005453-4057qib7 7610 34 . . . cord-005453-4057qib7 7611 1 Hence hence RB cord-005453-4057qib7 7611 2 , , , cord-005453-4057qib7 7611 3 an an DT cord-005453-4057qib7 7611 4 ex ex FW cord-005453-4057qib7 7611 5 vivo vivo NN cord-005453-4057qib7 7611 6 platform platform NN cord-005453-4057qib7 7611 7 is be VBZ cord-005453-4057qib7 7611 8 needed need VBN cord-005453-4057qib7 7611 9 that that WDT cord-005453-4057qib7 7611 10 supports support VBZ cord-005453-4057qib7 7611 11 HSC HSC NNP cord-005453-4057qib7 7611 12 proliferation proliferation NN cord-005453-4057qib7 7611 13 before before IN cord-005453-4057qib7 7611 14 application application NN cord-005453-4057qib7 7611 15 and and CC cord-005453-4057qib7 7611 16 , , , cord-005453-4057qib7 7611 17 at at IN cord-005453-4057qib7 7611 18 the the DT cord-005453-4057qib7 7611 19 same same JJ cord-005453-4057qib7 7611 20 time time NN cord-005453-4057qib7 7611 21 , , , cord-005453-4057qib7 7611 22 the the DT cord-005453-4057qib7 7611 23 maintenance maintenance NN cord-005453-4057qib7 7611 24 of of IN cord-005453-4057qib7 7611 25 pluripotency pluripotency NN cord-005453-4057qib7 7611 26 by by IN cord-005453-4057qib7 7611 27 diminishing diminish VBG cord-005453-4057qib7 7611 28 HSC HSC NNP cord-005453-4057qib7 7611 29 differentiation differentiation NN cord-005453-4057qib7 7611 30 into into IN cord-005453-4057qib7 7611 31 lineage lineage NN cord-005453-4057qib7 7611 32 - - HYPH cord-005453-4057qib7 7611 33 specific specific JJ cord-005453-4057qib7 7611 34 progenitor progenitor NN cord-005453-4057qib7 7611 35 cells cell NNS cord-005453-4057qib7 7611 36 . . . cord-005453-4057qib7 7612 1 Methods method NNS cord-005453-4057qib7 7612 2 : : : cord-005453-4057qib7 7612 3 To to TO cord-005453-4057qib7 7612 4 artificially artificially RB cord-005453-4057qib7 7612 5 model model VB cord-005453-4057qib7 7612 6 the the DT cord-005453-4057qib7 7612 7 natural natural JJ cord-005453-4057qib7 7612 8 HSC HSC NNP cord-005453-4057qib7 7612 9 niche niche NN cord-005453-4057qib7 7612 10 in in IN cord-005453-4057qib7 7612 11 vitro vitro FW cord-005453-4057qib7 7612 12 , , , cord-005453-4057qib7 7612 13 we -PRON- PRP cord-005453-4057qib7 7612 14 used use VBD cord-005453-4057qib7 7612 15 3D 3d JJ cord-005453-4057qib7 7612 16 bone bone NN cord-005453-4057qib7 7612 17 marrow marrow NN cord-005453-4057qib7 7612 18 ( ( -LRB- cord-005453-4057qib7 7612 19 BM)-like bm)-like IN cord-005453-4057qib7 7612 20 scaffolds scaffold NNS cord-005453-4057qib7 7612 21 made make VBN cord-005453-4057qib7 7612 22 of of IN cord-005453-4057qib7 7612 23 polydimethylsiloxane polydimethylsiloxane NNP cord-005453-4057qib7 7612 24 ( ( -LRB- cord-005453-4057qib7 7612 25 PDMS PDMS NNP cord-005453-4057qib7 7612 26 ) ) -RRB- cord-005453-4057qib7 7612 27 . . . cord-005453-4057qib7 7613 1 These these DT cord-005453-4057qib7 7613 2 structures structure NNS cord-005453-4057qib7 7613 3 are be VBP cord-005453-4057qib7 7613 4 based base VBN cord-005453-4057qib7 7613 5 on on IN cord-005453-4057qib7 7613 6 a a DT cord-005453-4057qib7 7613 7 human human JJ cord-005453-4057qib7 7613 8 long long JJ cord-005453-4057qib7 7613 9 bone bone NN cord-005453-4057qib7 7613 10 cross cross NN cord-005453-4057qib7 7613 11 section section NN cord-005453-4057qib7 7613 12 as as IN cord-005453-4057qib7 7613 13 a a DT cord-005453-4057qib7 7613 14 representative representative NN cord-005453-4057qib7 7613 15 of of IN cord-005453-4057qib7 7613 16 the the DT cord-005453-4057qib7 7613 17 BM BM NNP cord-005453-4057qib7 7613 18 . . . cord-005453-4057qib7 7614 1 Human human JJ cord-005453-4057qib7 7614 2 cryoconserved cryoconserve VBN cord-005453-4057qib7 7614 3 HSCs HSCs NNP cord-005453-4057qib7 7614 4 were be VBD cord-005453-4057qib7 7614 5 cultured culture VBN cord-005453-4057qib7 7614 6 in in IN cord-005453-4057qib7 7614 7 distinct distinct JJ cord-005453-4057qib7 7614 8 cultivation cultivation NN cord-005453-4057qib7 7614 9 systems system NNS cord-005453-4057qib7 7614 10 for for IN cord-005453-4057qib7 7614 11 14 14 CD cord-005453-4057qib7 7614 12 days day NNS cord-005453-4057qib7 7614 13 under under IN cord-005453-4057qib7 7614 14 different different JJ cord-005453-4057qib7 7614 15 conditions condition NNS cord-005453-4057qib7 7614 16 . . . cord-005453-4057qib7 7615 1 Cell cell NN cord-005453-4057qib7 7615 2 counting counting NN cord-005453-4057qib7 7615 3 and and CC cord-005453-4057qib7 7615 4 FACS FACS NNP cord-005453-4057qib7 7615 5 analyses analysis NNS cord-005453-4057qib7 7615 6 at at IN cord-005453-4057qib7 7615 7 day day NN cord-005453-4057qib7 7615 8 14 14 CD cord-005453-4057qib7 7615 9 were be VBD cord-005453-4057qib7 7615 10 conducted conduct VBN cord-005453-4057qib7 7615 11 . . . cord-005453-4057qib7 7616 1 For for IN cord-005453-4057qib7 7616 2 characterization characterization NN cord-005453-4057qib7 7616 3 of of IN cord-005453-4057qib7 7616 4 the the DT cord-005453-4057qib7 7616 5 cultivated cultivate VBN cord-005453-4057qib7 7616 6 HSCs hscs NN cord-005453-4057qib7 7616 7 , , , cord-005453-4057qib7 7616 8 we -PRON- PRP cord-005453-4057qib7 7616 9 used use VBD cord-005453-4057qib7 7616 10 antibodies antibody NNS cord-005453-4057qib7 7616 11 against against IN cord-005453-4057qib7 7616 12 CD34 CD34 NNP cord-005453-4057qib7 7616 13 alone alone RB cord-005453-4057qib7 7616 14 or or CC cord-005453-4057qib7 7616 15 in in IN cord-005453-4057qib7 7616 16 combination combination NN cord-005453-4057qib7 7616 17 with with IN cord-005453-4057qib7 7616 18 antibodies antibody NNS cord-005453-4057qib7 7616 19 against against IN cord-005453-4057qib7 7616 20 CD38 CD38 NNP cord-005453-4057qib7 7616 21 , , , cord-005453-4057qib7 7616 22 CD90 CD90 NNP cord-005453-4057qib7 7616 23 , , , cord-005453-4057qib7 7616 24 CD45RA cd45ra NN cord-005453-4057qib7 7616 25 and and CC cord-005453-4057qib7 7616 26 CD49f cd49f NN cord-005453-4057qib7 7616 27 . . . cord-005453-4057qib7 7617 1 Results result NNS cord-005453-4057qib7 7617 2 : : : cord-005453-4057qib7 7618 1 For for IN cord-005453-4057qib7 7618 2 optimization optimization NN cord-005453-4057qib7 7618 3 of of IN cord-005453-4057qib7 7618 4 culture culture NN cord-005453-4057qib7 7618 5 conditions condition NNS cord-005453-4057qib7 7618 6 for for IN cord-005453-4057qib7 7618 7 human human JJ cord-005453-4057qib7 7618 8 HSCs hscs NN cord-005453-4057qib7 7618 9 , , , cord-005453-4057qib7 7618 10 a a DT cord-005453-4057qib7 7618 11 commercially commercially RB cord-005453-4057qib7 7618 12 available available JJ cord-005453-4057qib7 7618 13 medium medium NN cord-005453-4057qib7 7618 14 was be VBD cord-005453-4057qib7 7618 15 supplemented supplement VBN cord-005453-4057qib7 7618 16 with with IN cord-005453-4057qib7 7618 17 a a DT cord-005453-4057qib7 7618 18 panel panel NN cord-005453-4057qib7 7618 19 of of IN cord-005453-4057qib7 7618 20 cytokines cytokine NNS cord-005453-4057qib7 7618 21 and and CC cord-005453-4057qib7 7618 22 valproic valproic NN cord-005453-4057qib7 7618 23 acid acid NN cord-005453-4057qib7 7618 24 . . . cord-005453-4057qib7 7619 1 We -PRON- PRP cord-005453-4057qib7 7619 2 found find VBD cord-005453-4057qib7 7619 3 a a DT cord-005453-4057qib7 7619 4 significant significant JJ cord-005453-4057qib7 7619 5 increase increase NN cord-005453-4057qib7 7619 6 in in IN cord-005453-4057qib7 7619 7 the the DT cord-005453-4057qib7 7619 8 number number NN cord-005453-4057qib7 7619 9 of of IN cord-005453-4057qib7 7619 10 CD34 CD34 NNP cord-005453-4057qib7 7619 11 + + CC cord-005453-4057qib7 7619 12 HSCs hscs NN cord-005453-4057qib7 7619 13 by by IN cord-005453-4057qib7 7619 14 simultaneously simultaneously RB cord-005453-4057qib7 7619 15 increasing increase VBG cord-005453-4057qib7 7619 16 their -PRON- PRP$ cord-005453-4057qib7 7619 17 vitality vitality NN cord-005453-4057qib7 7619 18 using use VBG cord-005453-4057qib7 7619 19 the the DT cord-005453-4057qib7 7619 20 3D 3d JJ cord-005453-4057qib7 7619 21 system system NN cord-005453-4057qib7 7619 22 compared compare VBN cord-005453-4057qib7 7619 23 with with IN cord-005453-4057qib7 7619 24 conventional conventional JJ cord-005453-4057qib7 7619 25 2D 2d NN cord-005453-4057qib7 7619 26 culturing culturing NN cord-005453-4057qib7 7619 27 . . . cord-005453-4057qib7 7620 1 A a DT cord-005453-4057qib7 7620 2 further further JJ cord-005453-4057qib7 7620 3 improvement improvement NN cord-005453-4057qib7 7620 4 was be VBD cord-005453-4057qib7 7620 5 achieved achieve VBN cord-005453-4057qib7 7620 6 by by IN cord-005453-4057qib7 7620 7 introducing introduce VBG cord-005453-4057qib7 7620 8 a a DT cord-005453-4057qib7 7620 9 silicon silicon NN cord-005453-4057qib7 7620 10 oxidecovering oxidecovering NN cord-005453-4057qib7 7620 11 of of IN cord-005453-4057qib7 7620 12 the the DT cord-005453-4057qib7 7620 13 3D 3d JJ cord-005453-4057qib7 7620 14 PDMS PDMS NNP cord-005453-4057qib7 7620 15 structures structure NNS cord-005453-4057qib7 7620 16 , , , cord-005453-4057qib7 7620 17 suggesting suggest VBG cord-005453-4057qib7 7620 18 that that IN cord-005453-4057qib7 7620 19 hydrophilic hydrophilic JJ cord-005453-4057qib7 7620 20 surface surface NN cord-005453-4057qib7 7620 21 properties property NNS cord-005453-4057qib7 7620 22 offer offer VBP cord-005453-4057qib7 7620 23 superior superior JJ cord-005453-4057qib7 7620 24 attachment attachment NN cord-005453-4057qib7 7620 25 for for IN cord-005453-4057qib7 7620 26 semi semi JJ cord-005453-4057qib7 7620 27 - - JJ cord-005453-4057qib7 7620 28 adherent adherent JJ cord-005453-4057qib7 7620 29 HSCs hscs NN cord-005453-4057qib7 7620 30 . . . cord-005453-4057qib7 7621 1 For for IN cord-005453-4057qib7 7621 2 a a DT cord-005453-4057qib7 7621 3 more more RBR cord-005453-4057qib7 7621 4 precise precise JJ cord-005453-4057qib7 7621 5 characterization characterization NN cord-005453-4057qib7 7621 6 of of IN cord-005453-4057qib7 7621 7 the the DT cord-005453-4057qib7 7621 8 cultivated cultivate VBN cord-005453-4057qib7 7621 9 HSCs hscs NN cord-005453-4057qib7 7621 10 , , , cord-005453-4057qib7 7621 11 we -PRON- PRP cord-005453-4057qib7 7621 12 introduced introduce VBD cord-005453-4057qib7 7621 13 a a DT cord-005453-4057qib7 7621 14 panel panel NN cord-005453-4057qib7 7621 15 of of IN cord-005453-4057qib7 7621 16 FACS FACS NNP cord-005453-4057qib7 7621 17 markers marker NNS cord-005453-4057qib7 7621 18 reflecting reflect VBG cord-005453-4057qib7 7621 19 the the DT cord-005453-4057qib7 7621 20 immaturity immaturity NN cord-005453-4057qib7 7621 21 of of IN cord-005453-4057qib7 7621 22 the the DT cord-005453-4057qib7 7621 23 amplified amplify VBN cord-005453-4057qib7 7621 24 HSC HSC NNP cord-005453-4057qib7 7621 25 . . . cord-005453-4057qib7 7622 1 Surprisingly surprisingly RB cord-005453-4057qib7 7622 2 , , , cord-005453-4057qib7 7622 3 with with IN cord-005453-4057qib7 7622 4 increasing increase VBG cord-005453-4057qib7 7622 5 immaturity immaturity NN cord-005453-4057qib7 7622 6 of of IN cord-005453-4057qib7 7622 7 the the DT cord-005453-4057qib7 7622 8 cultivated cultivate VBN cord-005453-4057qib7 7622 9 HSC HSC NNP cord-005453-4057qib7 7622 10 , , , cord-005453-4057qib7 7622 11 non non JJ cord-005453-4057qib7 7622 12 - - JJ cord-005453-4057qib7 7622 13 covered covered JJ cord-005453-4057qib7 7622 14 3D 3d JJ cord-005453-4057qib7 7622 15 PDMS PDMS NNP cord-005453-4057qib7 7622 16 revealed reveal VBD cord-005453-4057qib7 7622 17 to to TO cord-005453-4057qib7 7622 18 be be VB cord-005453-4057qib7 7622 19 best well RBS cord-005453-4057qib7 7622 20 suited suit VBN cord-005453-4057qib7 7622 21 for for IN cord-005453-4057qib7 7622 22 amplification amplification NN cord-005453-4057qib7 7622 23 : : : cord-005453-4057qib7 7622 24 Cell cell NN cord-005453-4057qib7 7622 25 number number NN cord-005453-4057qib7 7622 26 of of IN cord-005453-4057qib7 7622 27 vital vital JJ cord-005453-4057qib7 7622 28 immature immature JJ cord-005453-4057qib7 7622 29 HSCs hscs NN cord-005453-4057qib7 7622 30 was be VBD cord-005453-4057qib7 7622 31 increased increase VBN cord-005453-4057qib7 7622 32 after after IN cord-005453-4057qib7 7622 33 cultivation cultivation NN cord-005453-4057qib7 7622 34 on on IN cord-005453-4057qib7 7622 35 non non JJ cord-005453-4057qib7 7622 36 - - JJ cord-005453-4057qib7 7622 37 covered covered JJ cord-005453-4057qib7 7622 38 3D 3d JJ cord-005453-4057qib7 7622 39 PDMS PDMS NNP cord-005453-4057qib7 7622 40 compared compare VBN cord-005453-4057qib7 7622 41 with with IN cord-005453-4057qib7 7622 42 silicon silicon NN cord-005453-4057qib7 7622 43 oxide oxide NN cord-005453-4057qib7 7622 44 - - HYPH cord-005453-4057qib7 7622 45 covered cover VBN cord-005453-4057qib7 7622 46 3D 3d JJ cord-005453-4057qib7 7622 47 PDMS PDMS NNP cord-005453-4057qib7 7622 48 and and CC cord-005453-4057qib7 7622 49 the the DT cord-005453-4057qib7 7622 50 2D 2d NN cord-005453-4057qib7 7622 51 system system NN cord-005453-4057qib7 7622 52 . . . cord-005453-4057qib7 7623 1 Conclusions conclusion NNS cord-005453-4057qib7 7623 2 : : : cord-005453-4057qib7 7624 1 By by IN cord-005453-4057qib7 7624 2 establishing establish VBG cord-005453-4057qib7 7624 3 a a DT cord-005453-4057qib7 7624 4 3D 3d JJ cord-005453-4057qib7 7624 5 scaffold scaffold NN cord-005453-4057qib7 7624 6 according accord VBG cord-005453-4057qib7 7624 7 to to IN cord-005453-4057qib7 7624 8 the the DT cord-005453-4057qib7 7624 9 human human JJ cord-005453-4057qib7 7624 10 BM bm NN cord-005453-4057qib7 7624 11 , , , cord-005453-4057qib7 7624 12 we -PRON- PRP cord-005453-4057qib7 7624 13 found find VBD cord-005453-4057qib7 7624 14 a a DT cord-005453-4057qib7 7624 15 platform platform NN cord-005453-4057qib7 7624 16 mimicking mimic VBG cord-005453-4057qib7 7624 17 the the DT cord-005453-4057qib7 7624 18 natural natural JJ cord-005453-4057qib7 7624 19 niche niche NN cord-005453-4057qib7 7624 20 of of IN cord-005453-4057qib7 7624 21 human human JJ cord-005453-4057qib7 7624 22 HSC HSC NNP cord-005453-4057qib7 7624 23 which which WDT cord-005453-4057qib7 7624 24 is be VBZ cord-005453-4057qib7 7624 25 suitable suitable JJ cord-005453-4057qib7 7624 26 to to TO cord-005453-4057qib7 7624 27 amplify amplify VB cord-005453-4057qib7 7624 28 human human JJ cord-005453-4057qib7 7624 29 HSCs hscs NN cord-005453-4057qib7 7624 30 in in IN cord-005453-4057qib7 7624 31 vitro vitro FW cord-005453-4057qib7 7624 32 and and CC cord-005453-4057qib7 7624 33 support support VB cord-005453-4057qib7 7624 34 their -PRON- PRP$ cord-005453-4057qib7 7624 35 vitality vitality NN cord-005453-4057qib7 7624 36 , , , cord-005453-4057qib7 7624 37 pluripotency pluripotency NN cord-005453-4057qib7 7624 38 and and CC cord-005453-4057qib7 7624 39 ability ability NN cord-005453-4057qib7 7624 40 for for IN cord-005453-4057qib7 7624 41 self self NN cord-005453-4057qib7 7624 42 - - HYPH cord-005453-4057qib7 7624 43 renewal renewal NN cord-005453-4057qib7 7624 44 . . . cord-005453-4057qib7 7625 1 [ [ -LRB- cord-005453-4057qib7 7625 2 [ [ -LRB- cord-005453-4057qib7 7625 3 P341 p341 NN cord-005453-4057qib7 7625 4 Image image NN cord-005453-4057qib7 7625 5 ] ] -RRB- cord-005453-4057qib7 7625 6 1 1 CD cord-005453-4057qib7 7625 7 . . . cord-005453-4057qib7 7626 1 With with IN cord-005453-4057qib7 7626 2 the the DT cord-005453-4057qib7 7626 3 introduction introduction NN cord-005453-4057qib7 7626 4 of of IN cord-005453-4057qib7 7626 5 SiOn SiOn NNP cord-005453-4057qib7 7626 6 covering cover VBG cord-005453-4057qib7 7626 7 of of IN cord-005453-4057qib7 7626 8 3D 3d JJ cord-005453-4057qib7 7626 9 PDMS PDMS NNP cord-005453-4057qib7 7626 10 structures structure NNS cord-005453-4057qib7 7626 11 the the DT cord-005453-4057qib7 7626 12 maintenance maintenance NN cord-005453-4057qib7 7626 13 of of IN cord-005453-4057qib7 7626 14 CD34 CD34 NNP cord-005453-4057qib7 7626 15 + + CC cord-005453-4057qib7 7626 16 HSCs hscs NN cord-005453-4057qib7 7626 17 could could MD cord-005453-4057qib7 7626 18 be be VB cord-005453-4057qib7 7626 19 further further RB cord-005453-4057qib7 7626 20 improved improve VBN cord-005453-4057qib7 7626 21 . . . cord-005453-4057qib7 7627 1 Despite despite IN cord-005453-4057qib7 7627 2 the the DT cord-005453-4057qib7 7627 3 better well JJR cord-005453-4057qib7 7627 4 conservation conservation NN cord-005453-4057qib7 7627 5 of of IN cord-005453-4057qib7 7627 6 CD34 CD34 NNP cord-005453-4057qib7 7627 7 + + CC cord-005453-4057qib7 7627 8 HSCs hscs NN cord-005453-4057qib7 7627 9 by by IN cord-005453-4057qib7 7627 10 using use VBG cord-005453-4057qib7 7627 11 silicon silicon NN cord-005453-4057qib7 7627 12 oxide oxide NN cord-005453-4057qib7 7627 13 - - HYPH cord-005453-4057qib7 7627 14 covered cover VBN cord-005453-4057qib7 7627 15 3D 3d JJ cord-005453-4057qib7 7627 16 PDMS PDMS NNP cord-005453-4057qib7 7627 17 , , , cord-005453-4057qib7 7627 18 we -PRON- PRP cord-005453-4057qib7 7627 19 found find VBD cord-005453-4057qib7 7627 20 that that IN cord-005453-4057qib7 7627 21 immature immature JJ cord-005453-4057qib7 7627 22 human human JJ cord-005453-4057qib7 7627 23 HSCs hsc NNS cord-005453-4057qib7 7627 24 obviously obviously RB cord-005453-4057qib7 7627 25 prefer prefer VBP cord-005453-4057qib7 7627 26 more more JJR cord-005453-4057qib7 7627 27 hydrophobic hydrophobic JJ cord-005453-4057qib7 7627 28 conditions condition NNS cord-005453-4057qib7 7627 29 found find VBN cord-005453-4057qib7 7627 30 on on IN cord-005453-4057qib7 7627 31 non non JJ cord-005453-4057qib7 7627 32 - - JJ cord-005453-4057qib7 7627 33 covered covered JJ cord-005453-4057qib7 7627 34 3D 3d JJ cord-005453-4057qib7 7627 35 PDMS PDMS NNP cord-005453-4057qib7 7627 36 . . . cord-005453-4057qib7 7628 1 Disclosure disclosure NN cord-005453-4057qib7 7628 2 : : : cord-005453-4057qib7 7628 3 Nothing nothing NN cord-005453-4057qib7 7628 4 to to TO cord-005453-4057qib7 7628 5 declare declare VB cord-005453-4057qib7 7628 6 . . . cord-005453-4057qib7 7629 1 Abstract Abstract NNP cord-005453-4057qib7 7629 2 already already RB cord-005453-4057qib7 7629 3 published publish VBN cord-005453-4057qib7 7629 4 . . . cord-005453-4057qib7 7630 1 Improvements improvement NNS cord-005453-4057qib7 7630 2 in in IN cord-005453-4057qib7 7630 3 neutrophil neutrophil NN cord-005453-4057qib7 7630 4 engraftment engraftment NN cord-005453-4057qib7 7630 5 following follow VBG cord-005453-4057qib7 7630 6 changes change NNS cord-005453-4057qib7 7630 7 in in IN cord-005453-4057qib7 7630 8 freezing freezing NN cord-005453-4057qib7 7630 9 method method NN cord-005453-4057qib7 7630 10 Background background NN cord-005453-4057qib7 7630 11 : : : cord-005453-4057qib7 7630 12 In in IN cord-005453-4057qib7 7630 13 the the DT cord-005453-4057qib7 7630 14 setting setting NN cord-005453-4057qib7 7630 15 of of IN cord-005453-4057qib7 7630 16 autologous autologous JJ cord-005453-4057qib7 7630 17 haematopoietic haematopoietic JJ cord-005453-4057qib7 7630 18 progenitor progenitor NN cord-005453-4057qib7 7630 19 cell cell NN cord-005453-4057qib7 7630 20 ( ( -LRB- cord-005453-4057qib7 7630 21 HPC HPC NNP cord-005453-4057qib7 7630 22 ) ) -RRB- cord-005453-4057qib7 7630 23 transplants transplant NNS cord-005453-4057qib7 7630 24 for for IN cord-005453-4057qib7 7630 25 haematological haematological JJ cord-005453-4057qib7 7630 26 disorders disorder NNS cord-005453-4057qib7 7630 27 , , , cord-005453-4057qib7 7630 28 peripheral peripheral JJ cord-005453-4057qib7 7630 29 blood blood NN cord-005453-4057qib7 7630 30 stem stem NN cord-005453-4057qib7 7630 31 cells cell NNS cord-005453-4057qib7 7630 32 are be VBP cord-005453-4057qib7 7630 33 routinely routinely RB cord-005453-4057qib7 7630 34 collected collect VBN cord-005453-4057qib7 7630 35 via via IN cord-005453-4057qib7 7630 36 apheresis apheresis NN cord-005453-4057qib7 7630 37 and and CC cord-005453-4057qib7 7630 38 cryopreserved cryopreserve VBN cord-005453-4057qib7 7630 39 . . . cord-005453-4057qib7 7631 1 Leicester Leicester NNP cord-005453-4057qib7 7631 2 Royal Royal NNP cord-005453-4057qib7 7631 3 Infirmary Infirmary NNP cord-005453-4057qib7 7631 4 had have VBD cord-005453-4057qib7 7631 5 been be VBN cord-005453-4057qib7 7631 6 using use VBG cord-005453-4057qib7 7631 7 a a DT cord-005453-4057qib7 7631 8 controlled control VBN cord-005453-4057qib7 7631 9 rate rate NN cord-005453-4057qib7 7631 10 freezer freezer NN cord-005453-4057qib7 7631 11 ( ( -LRB- cord-005453-4057qib7 7631 12 CRF CRF NNP cord-005453-4057qib7 7631 13 ) ) -RRB- cord-005453-4057qib7 7631 14 to to TO cord-005453-4057qib7 7631 15 cryopreserve cryopreserve VB cord-005453-4057qib7 7631 16 cellular cellular JJ cord-005453-4057qib7 7631 17 therapy therapy NN cord-005453-4057qib7 7631 18 products product NNS cord-005453-4057qib7 7631 19 up up IN cord-005453-4057qib7 7631 20 until until IN cord-005453-4057qib7 7631 21 2017 2017 CD cord-005453-4057qib7 7631 22 . . . cord-005453-4057qib7 7632 1 In in IN cord-005453-4057qib7 7632 2 2017 2017 CD cord-005453-4057qib7 7632 3 a a DT cord-005453-4057qib7 7632 4 literature literature NN cord-005453-4057qib7 7632 5 review review NN cord-005453-4057qib7 7632 6 of of IN cord-005453-4057qib7 7632 7 cryopreservation cryopreservation NN cord-005453-4057qib7 7632 8 techniques technique NNS cord-005453-4057qib7 7632 9 was be VBD cord-005453-4057qib7 7632 10 undertaken undertake VBN cord-005453-4057qib7 7632 11 , , , cord-005453-4057qib7 7632 12 since since IN cord-005453-4057qib7 7632 13 the the DT cord-005453-4057qib7 7632 14 CRF CRF NNP cord-005453-4057qib7 7632 15 required require VBN cord-005453-4057qib7 7632 16 replacement replacement NN cord-005453-4057qib7 7632 17 . . . cord-005453-4057qib7 7633 1 This this DT cord-005453-4057qib7 7633 2 review review NN cord-005453-4057qib7 7633 3 found find VBD cord-005453-4057qib7 7633 4 consistent consistent JJ cord-005453-4057qib7 7633 5 evidence evidence NN cord-005453-4057qib7 7633 6 that that IN cord-005453-4057qib7 7633 7 cryopreservation cryopreservation NN cord-005453-4057qib7 7633 8 using use VBG cord-005453-4057qib7 7633 9 minus minus NN cord-005453-4057qib7 7633 10 80 80 CD cord-005453-4057qib7 7633 11 o o NN cord-005453-4057qib7 7633 12 C c NN cord-005453-4057qib7 7633 13 is be VBZ cord-005453-4057qib7 7633 14 comparable comparable JJ cord-005453-4057qib7 7633 15 to to IN cord-005453-4057qib7 7633 16 CRF CRF NNP cord-005453-4057qib7 7633 17 , , , cord-005453-4057qib7 7633 18 and and CC cord-005453-4057qib7 7633 19 engraftment engraftment NN cord-005453-4057qib7 7633 20 times time NNS cord-005453-4057qib7 7633 21 should should MD cord-005453-4057qib7 7633 22 not not RB cord-005453-4057qib7 7633 23 be be VB cord-005453-4057qib7 7633 24 negatively negatively RB cord-005453-4057qib7 7633 25 affected affect VBN cord-005453-4057qib7 7633 26 by by IN cord-005453-4057qib7 7633 27 changing change VBG cord-005453-4057qib7 7633 28 to to IN cord-005453-4057qib7 7633 29 a a DT cord-005453-4057qib7 7633 30 more more RBR cord-005453-4057qib7 7633 31 simplified simplified JJ cord-005453-4057qib7 7633 32 method method NN cord-005453-4057qib7 7633 33 of of IN cord-005453-4057qib7 7633 34 freezing freezing NN cord-005453-4057qib7 7633 35 . . . cord-005453-4057qib7 7634 1 There there EX cord-005453-4057qib7 7634 2 would would MD cord-005453-4057qib7 7634 3 also also RB cord-005453-4057qib7 7634 4 be be VB cord-005453-4057qib7 7634 5 cost cost NN cord-005453-4057qib7 7634 6 saving saving NN cord-005453-4057qib7 7634 7 benefits benefit NNS cord-005453-4057qib7 7634 8 from from IN cord-005453-4057qib7 7634 9 switching switch VBG cord-005453-4057qib7 7634 10 from from IN cord-005453-4057qib7 7634 11 a a DT cord-005453-4057qib7 7634 12 CRF crf NN cord-005453-4057qib7 7634 13 to to IN cord-005453-4057qib7 7634 14 minus minus NN cord-005453-4057qib7 7634 15 80 80 CD cord-005453-4057qib7 7634 16 o o NN cord-005453-4057qib7 7634 17 C c NN cord-005453-4057qib7 7634 18 freezers freezer NNS cord-005453-4057qib7 7634 19 . . . cord-005453-4057qib7 7635 1 Methods method NNS cord-005453-4057qib7 7635 2 : : : cord-005453-4057qib7 7636 1 As as IN cord-005453-4057qib7 7636 2 a a DT cord-005453-4057qib7 7636 3 result result NN cord-005453-4057qib7 7636 4 two two CD cord-005453-4057qib7 7636 5 minus minus CC cord-005453-4057qib7 7636 6 80 80 CD cord-005453-4057qib7 7636 7 o o NN cord-005453-4057qib7 7636 8 C c NN cord-005453-4057qib7 7636 9 freezers freezer NNS cord-005453-4057qib7 7636 10 were be VBD cord-005453-4057qib7 7636 11 purchased purchase VBN cord-005453-4057qib7 7636 12 following follow VBG cord-005453-4057qib7 7636 13 the the DT cord-005453-4057qib7 7636 14 acceptance acceptance NN cord-005453-4057qib7 7636 15 of of IN cord-005453-4057qib7 7636 16 a a DT cord-005453-4057qib7 7636 17 Preparation Preparation NNP cord-005453-4057qib7 7636 18 Process process NN cord-005453-4057qib7 7636 19 Dosier Dosier NNP cord-005453-4057qib7 7636 20 ( ( -LRB- cord-005453-4057qib7 7636 21 PPD PPD NNP cord-005453-4057qib7 7636 22 ) ) -RRB- cord-005453-4057qib7 7636 23 which which WDT cord-005453-4057qib7 7636 24 was be VBD cord-005453-4057qib7 7636 25 prepared prepare VBN cord-005453-4057qib7 7636 26 for for IN cord-005453-4057qib7 7636 27 the the DT cord-005453-4057qib7 7636 28 Human Human NNP cord-005453-4057qib7 7636 29 Tissue Tissue NNP cord-005453-4057qib7 7636 30 Authority Authority NNP cord-005453-4057qib7 7636 31 . . . cord-005453-4057qib7 7637 1 Validation validation NN cord-005453-4057qib7 7637 2 was be VBD cord-005453-4057qib7 7637 3 carried carry VBN cord-005453-4057qib7 7637 4 out out RP cord-005453-4057qib7 7637 5 , , , cord-005453-4057qib7 7637 6 and and CC cord-005453-4057qib7 7637 7 from from IN cord-005453-4057qib7 7637 8 January January NNP cord-005453-4057qib7 7637 9 2018 2018 CD cord-005453-4057qib7 7637 10 stem stem NN cord-005453-4057qib7 7637 11 cell cell NN cord-005453-4057qib7 7637 12 laboratory laboratory NN cord-005453-4057qib7 7637 13 at at IN cord-005453-4057qib7 7637 14 the the DT cord-005453-4057qib7 7637 15 LRI LRI NNP cord-005453-4057qib7 7637 16 switched switch VBD cord-005453-4057qib7 7637 17 from from IN cord-005453-4057qib7 7637 18 the the DT cord-005453-4057qib7 7637 19 CRF CRF NNP cord-005453-4057qib7 7637 20 method method NN cord-005453-4057qib7 7637 21 to to IN cord-005453-4057qib7 7637 22 minus minus IN cord-005453-4057qib7 7637 23 80 80 CD cord-005453-4057qib7 7637 24 o o NN cord-005453-4057qib7 7637 25 C c NN cord-005453-4057qib7 7637 26 for for IN cord-005453-4057qib7 7637 27 cryopreservation cryopreservation NN cord-005453-4057qib7 7637 28 of of IN cord-005453-4057qib7 7637 29 cellular cellular JJ cord-005453-4057qib7 7637 30 therapy therapy NN cord-005453-4057qib7 7637 31 products product NNS cord-005453-4057qib7 7637 32 . . . cord-005453-4057qib7 7638 1 Briefly briefly RB cord-005453-4057qib7 7638 2 , , , cord-005453-4057qib7 7638 3 cells cell NNS cord-005453-4057qib7 7638 4 are be VBP cord-005453-4057qib7 7638 5 frozen freeze VBN cord-005453-4057qib7 7638 6 using use VBG cord-005453-4057qib7 7638 7 10 10 CD cord-005453-4057qib7 7638 8 % % NN cord-005453-4057qib7 7638 9 DMSO DMSO NNP cord-005453-4057qib7 7638 10 ( ( -LRB- cord-005453-4057qib7 7638 11 Wak Wak NNP cord-005453-4057qib7 7638 12 - - HYPH cord-005453-4057qib7 7638 13 Chemie Chemie NNP cord-005453-4057qib7 7638 14 ) ) -RRB- cord-005453-4057qib7 7638 15 in in IN cord-005453-4057qib7 7638 16 20g 20g NNPS cord-005453-4057qib7 7638 17 / / SYM cord-005453-4057qib7 7638 18 l l NNP cord-005453-4057qib7 7638 19 Human Human NNP cord-005453-4057qib7 7638 20 Albumin Albumin NNP cord-005453-4057qib7 7638 21 Solution Solution NNP cord-005453-4057qib7 7638 22 ( ( -LRB- cord-005453-4057qib7 7638 23 Grifols Grifols NNP cord-005453-4057qib7 7638 24 ) ) -RRB- cord-005453-4057qib7 7638 25 in in IN cord-005453-4057qib7 7638 26 Cyrobags Cyrobags NNP cord-005453-4057qib7 7638 27 ( ( -LRB- cord-005453-4057qib7 7638 28 Origen Origen NNP cord-005453-4057qib7 7638 29 Biomedical Biomedical NNP cord-005453-4057qib7 7638 30 , , , cord-005453-4057qib7 7638 31 Inc Inc NNP cord-005453-4057qib7 7638 32 ) ) -RRB- cord-005453-4057qib7 7638 33 . . . cord-005453-4057qib7 7639 1 The the DT cord-005453-4057qib7 7639 2 cells cell NNS cord-005453-4057qib7 7639 3 are be VBP cord-005453-4057qib7 7639 4 transferred transfer VBN cord-005453-4057qib7 7639 5 on on IN cord-005453-4057qib7 7639 6 cold cold JJ cord-005453-4057qib7 7639 7 packs pack NNS cord-005453-4057qib7 7639 8 to to IN cord-005453-4057qib7 7639 9 the the DT cord-005453-4057qib7 7639 10 minus minus NN cord-005453-4057qib7 7639 11 80 80 CD cord-005453-4057qib7 7639 12 o o NN cord-005453-4057qib7 7639 13 C c NN cord-005453-4057qib7 7639 14 freezer freezer NN cord-005453-4057qib7 7639 15 . . . cord-005453-4057qib7 7640 1 Cells cell NNS cord-005453-4057qib7 7640 2 are be VBP cord-005453-4057qib7 7640 3 packaged package VBN cord-005453-4057qib7 7640 4 in in IN cord-005453-4057qib7 7640 5 between between IN cord-005453-4057qib7 7640 6 stainless stainless JJ cord-005453-4057qib7 7640 7 steel steel NN cord-005453-4057qib7 7640 8 heattransfer heattransfer NN cord-005453-4057qib7 7640 9 plates plate NNS cord-005453-4057qib7 7640 10 . . . cord-005453-4057qib7 7641 1 The the DT cord-005453-4057qib7 7641 2 plates plate NNS cord-005453-4057qib7 7641 3 are be VBP cord-005453-4057qib7 7641 4 placed place VBN cord-005453-4057qib7 7641 5 within within IN cord-005453-4057qib7 7641 6 a a DT cord-005453-4057qib7 7641 7 bubble bubble NN cord-005453-4057qib7 7641 8 wrap wrap NN cord-005453-4057qib7 7641 9 bag bag NN cord-005453-4057qib7 7641 10 , , , cord-005453-4057qib7 7641 11 and and CC cord-005453-4057qib7 7641 12 are be VBP cord-005453-4057qib7 7641 13 placed place VBN cord-005453-4057qib7 7641 14 in in IN cord-005453-4057qib7 7641 15 a a DT cord-005453-4057qib7 7641 16 rack rack NN cord-005453-4057qib7 7641 17 within within IN cord-005453-4057qib7 7641 18 the the DT cord-005453-4057qib7 7641 19 minus minus NN cord-005453-4057qib7 7641 20 80 80 CD cord-005453-4057qib7 7641 21 o o NN cord-005453-4057qib7 7641 22 C c NN cord-005453-4057qib7 7641 23 freezer freezer NN cord-005453-4057qib7 7641 24 , , , cord-005453-4057qib7 7641 25 which which WDT cord-005453-4057qib7 7641 26 allows allow VBZ cord-005453-4057qib7 7641 27 air air NN cord-005453-4057qib7 7641 28 to to TO cord-005453-4057qib7 7641 29 circulate circulate VB cord-005453-4057qib7 7641 30 freely freely RB cord-005453-4057qib7 7641 31 around around IN cord-005453-4057qib7 7641 32 each each DT cord-005453-4057qib7 7641 33 bag bag NN cord-005453-4057qib7 7641 34 . . . cord-005453-4057qib7 7642 1 In in IN cord-005453-4057qib7 7642 2 one one CD cord-005453-4057qib7 7642 3 plate plate NN cord-005453-4057qib7 7642 4 a a DT cord-005453-4057qib7 7642 5 EL EL NNP cord-005453-4057qib7 7642 6 - - HYPH cord-005453-4057qib7 7642 7 USB usb NN cord-005453-4057qib7 7642 8 - - HYPH cord-005453-4057qib7 7642 9 TC tc NN cord-005453-4057qib7 7642 10 thermocouple thermocouple NN cord-005453-4057qib7 7642 11 data datum NNS cord-005453-4057qib7 7642 12 logger logger NN cord-005453-4057qib7 7642 13 ( ( -LRB- cord-005453-4057qib7 7642 14 Thermosense Thermosense NNP cord-005453-4057qib7 7642 15 ) ) -RRB- cord-005453-4057qib7 7642 16 is be VBZ cord-005453-4057qib7 7642 17 inserted insert VBN cord-005453-4057qib7 7642 18 between between IN cord-005453-4057qib7 7642 19 the the DT cord-005453-4057qib7 7642 20 bag bag NN cord-005453-4057qib7 7642 21 and and CC cord-005453-4057qib7 7642 22 stainless stainless JJ cord-005453-4057qib7 7642 23 steel steel NN cord-005453-4057qib7 7642 24 plate plate NN cord-005453-4057qib7 7642 25 , , , cord-005453-4057qib7 7642 26 to to TO cord-005453-4057qib7 7642 27 record record VB cord-005453-4057qib7 7642 28 the the DT cord-005453-4057qib7 7642 29 freezing freeze VBG cord-005453-4057qib7 7642 30 profile profile NN cord-005453-4057qib7 7642 31 . . . cord-005453-4057qib7 7643 1 This this DT cord-005453-4057qib7 7643 2 data data NN cord-005453-4057qib7 7643 3 is be VBZ cord-005453-4057qib7 7643 4 downloaded download VBN cord-005453-4057qib7 7643 5 after after IN cord-005453-4057qib7 7643 6 each each DT cord-005453-4057qib7 7643 7 run run NN cord-005453-4057qib7 7643 8 . . . cord-005453-4057qib7 7644 1 After after IN cord-005453-4057qib7 7644 2 an an DT cord-005453-4057qib7 7644 3 overnight overnight JJ cord-005453-4057qib7 7644 4 freeze freeze NN cord-005453-4057qib7 7644 5 at at IN cord-005453-4057qib7 7644 6 minus minus NN cord-005453-4057qib7 7644 7 80 80 CD cord-005453-4057qib7 7644 8 o o NN cord-005453-4057qib7 7644 9 C c NN cord-005453-4057qib7 7644 10 , , , cord-005453-4057qib7 7644 11 the the DT cord-005453-4057qib7 7644 12 cells cell NNS cord-005453-4057qib7 7644 13 are be VBP cord-005453-4057qib7 7644 14 subsequently subsequently RB cord-005453-4057qib7 7644 15 removed remove VBN cord-005453-4057qib7 7644 16 from from IN cord-005453-4057qib7 7644 17 the the DT cord-005453-4057qib7 7644 18 bubble bubble NN cord-005453-4057qib7 7644 19 wrap wrap NN cord-005453-4057qib7 7644 20 and and CC cord-005453-4057qib7 7644 21 plates plate NNS cord-005453-4057qib7 7644 22 , , , cord-005453-4057qib7 7644 23 and and CC cord-005453-4057qib7 7644 24 are be VBP cord-005453-4057qib7 7644 25 transferred transfer VBN cord-005453-4057qib7 7644 26 to to IN cord-005453-4057qib7 7644 27 minus minus NN cord-005453-4057qib7 7644 28 150 150 CD cord-005453-4057qib7 7644 29 o o NN cord-005453-4057qib7 7644 30 C c NN cord-005453-4057qib7 7644 31 freezers freezer NNS cord-005453-4057qib7 7644 32 the the DT cord-005453-4057qib7 7644 33 following following JJ cord-005453-4057qib7 7644 34 morning morning NN cord-005453-4057qib7 7644 35 . . . cord-005453-4057qib7 7645 1 Results result NNS cord-005453-4057qib7 7645 2 : : : cord-005453-4057qib7 7646 1 A a DT cord-005453-4057qib7 7646 2 total total NN cord-005453-4057qib7 7646 3 of of IN cord-005453-4057qib7 7646 4 40 40 CD cord-005453-4057qib7 7646 5 patients patient NNS cord-005453-4057qib7 7646 6 have have VBP cord-005453-4057qib7 7646 7 had have VBN cord-005453-4057qib7 7646 8 autologous autologous JJ cord-005453-4057qib7 7646 9 stem stem NN cord-005453-4057qib7 7646 10 cells cell NNS cord-005453-4057qib7 7646 11 frozen freeze VBN cord-005453-4057qib7 7646 12 using use VBG cord-005453-4057qib7 7646 13 this this DT cord-005453-4057qib7 7646 14 method method NN cord-005453-4057qib7 7646 15 so so RB cord-005453-4057qib7 7646 16 far far RB cord-005453-4057qib7 7646 17 this this DT cord-005453-4057qib7 7646 18 year year NN cord-005453-4057qib7 7646 19 . . . cord-005453-4057qib7 7647 1 In in IN cord-005453-4057qib7 7647 2 addition addition NN cord-005453-4057qib7 7647 3 to to IN cord-005453-4057qib7 7647 4 engraftment engraftment NNP cord-005453-4057qib7 7647 5 data datum NNS cord-005453-4057qib7 7647 6 for for IN cord-005453-4057qib7 7647 7 neutrophils neutrophil NNS cord-005453-4057qib7 7647 8 , , , cord-005453-4057qib7 7647 9 post post JJ cord-005453-4057qib7 7647 10 - - JJ cord-005453-4057qib7 7647 11 freeze freeze JJ cord-005453-4057qib7 7647 12 trypan trypan NNP cord-005453-4057qib7 7647 13 blue blue JJ cord-005453-4057qib7 7647 14 viabilities viability NNS cord-005453-4057qib7 7647 15 were be VBD cord-005453-4057qib7 7647 16 also also RB cord-005453-4057qib7 7647 17 compared compare VBN cord-005453-4057qib7 7647 18 to to IN cord-005453-4057qib7 7647 19 the the DT cord-005453-4057qib7 7647 20 previous previous JJ cord-005453-4057qib7 7647 21 year year NN cord-005453-4057qib7 7647 22 . . . cord-005453-4057qib7 7648 1 During during IN cord-005453-4057qib7 7648 2 2017 2017 CD cord-005453-4057qib7 7648 3 a a DT cord-005453-4057qib7 7648 4 total total NN cord-005453-4057qib7 7648 5 of of IN cord-005453-4057qib7 7648 6 51 51 CD cord-005453-4057qib7 7648 7 patients patient NNS cord-005453-4057qib7 7648 8 , , , cord-005453-4057qib7 7648 9 who who WP cord-005453-4057qib7 7648 10 had have VBD cord-005453-4057qib7 7648 11 all all PDT cord-005453-4057qib7 7648 12 their -PRON- PRP$ cord-005453-4057qib7 7648 13 cells cell NNS cord-005453-4057qib7 7648 14 cryopreserved cryopreserve VBN cord-005453-4057qib7 7648 15 , , , cord-005453-4057qib7 7648 16 underwent undergo VBD cord-005453-4057qib7 7648 17 72 72 CD cord-005453-4057qib7 7648 18 collections collection NNS cord-005453-4057qib7 7648 19 . . . cord-005453-4057qib7 7649 1 The the DT cord-005453-4057qib7 7649 2 post post NN cord-005453-4057qib7 7649 3 freeze freeze NN cord-005453-4057qib7 7649 4 median median JJ cord-005453-4057qib7 7649 5 viability viability NN cord-005453-4057qib7 7649 6 was be VBD cord-005453-4057qib7 7649 7 90 90 CD cord-005453-4057qib7 7649 8 % % NN cord-005453-4057qib7 7649 9 ( ( -LRB- cord-005453-4057qib7 7649 10 75 75 CD cord-005453-4057qib7 7649 11 - - SYM cord-005453-4057qib7 7649 12 98 98 CD cord-005453-4057qib7 7649 13 % % NN cord-005453-4057qib7 7649 14 ) ) -RRB- cord-005453-4057qib7 7649 15 . . . cord-005453-4057qib7 7650 1 A a DT cord-005453-4057qib7 7650 2 total total NN cord-005453-4057qib7 7650 3 of of IN cord-005453-4057qib7 7650 4 median median JJ cord-005453-4057qib7 7650 5 neutrophil neutrophil NN cord-005453-4057qib7 7650 6 engraftment engraftment NN cord-005453-4057qib7 7650 7 was be VBD cord-005453-4057qib7 7650 8 12.0 12.0 CD cord-005453-4057qib7 7650 9 days day NNS cord-005453-4057qib7 7650 10 , , , cord-005453-4057qib7 7650 11 with with IN cord-005453-4057qib7 7650 12 a a DT cord-005453-4057qib7 7650 13 median median JJ cord-005453-4057qib7 7650 14 CD34 CD34 NNP cord-005453-4057qib7 7650 15 dose dose NN cord-005453-4057qib7 7650 16 infused infuse VBN cord-005453-4057qib7 7650 17 of of IN cord-005453-4057qib7 7650 18 4.0 4.0 CD cord-005453-4057qib7 7650 19 x x SYM cord-005453-4057qib7 7650 20 10 10 CD cord-005453-4057qib7 7650 21 6 6 CD cord-005453-4057qib7 7650 22 /kg /kg . cord-005453-4057qib7 7650 23 . . . cord-005453-4057qib7 7651 1 During during IN cord-005453-4057qib7 7651 2 2018 2018 CD cord-005453-4057qib7 7651 3 so so RB cord-005453-4057qib7 7651 4 far far RB cord-005453-4057qib7 7651 5 , , , cord-005453-4057qib7 7651 6 40 40 CD cord-005453-4057qib7 7651 7 patients patient NNS cord-005453-4057qib7 7651 8 have have VBP cord-005453-4057qib7 7651 9 undergone undergo VBN cord-005453-4057qib7 7651 10 57 57 CD cord-005453-4057qib7 7651 11 collections collection NNS cord-005453-4057qib7 7651 12 . . . cord-005453-4057qib7 7652 1 Median median JJ cord-005453-4057qib7 7652 2 viability viability NN cord-005453-4057qib7 7652 3 is be VBZ cord-005453-4057qib7 7652 4 95.5 95.5 CD cord-005453-4057qib7 7652 5 % % NN cord-005453-4057qib7 7652 6 ( ( -LRB- cord-005453-4057qib7 7652 7 82 82 CD cord-005453-4057qib7 7652 8 - - SYM cord-005453-4057qib7 7652 9 98 98 CD cord-005453-4057qib7 7652 10 % % NN cord-005453-4057qib7 7652 11 ) ) -RRB- cord-005453-4057qib7 7652 12 . . . cord-005453-4057qib7 7653 1 Subsequent subsequent JJ cord-005453-4057qib7 7653 2 median median JJ cord-005453-4057qib7 7653 3 neutrophil neutrophil NN cord-005453-4057qib7 7653 4 engraftment engraftment NN cord-005453-4057qib7 7653 5 is be VBZ cord-005453-4057qib7 7653 6 11 11 CD cord-005453-4057qib7 7653 7 days day NNS cord-005453-4057qib7 7653 8 , , , cord-005453-4057qib7 7653 9 with with IN cord-005453-4057qib7 7653 10 a a DT cord-005453-4057qib7 7653 11 median median JJ cord-005453-4057qib7 7653 12 CD34 CD34 NNP cord-005453-4057qib7 7653 13 dose dose NN cord-005453-4057qib7 7653 14 infused infuse VBN cord-005453-4057qib7 7653 15 of of IN cord-005453-4057qib7 7653 16 4.1 4.1 CD cord-005453-4057qib7 7653 17 x x SYM cord-005453-4057qib7 7653 18 10 10 CD cord-005453-4057qib7 7653 19 6 6 CD cord-005453-4057qib7 7653 20 /kg /kg . cord-005453-4057qib7 7653 21 . . . cord-005453-4057qib7 7654 1 Conclusions conclusion NNS cord-005453-4057qib7 7654 2 : : : cord-005453-4057qib7 7655 1 Ongoing ongoing JJ cord-005453-4057qib7 7655 2 savings saving NNS cord-005453-4057qib7 7655 3 of of IN cord-005453-4057qib7 7655 4 approximately approximately RB cord-005453-4057qib7 7655 5 £ £ $ cord-005453-4057qib7 7655 6 6400 6400 CD cord-005453-4057qib7 7655 7 per per IN cord-005453-4057qib7 7655 8 annum annum NN cord-005453-4057qib7 7655 9 have have VBP cord-005453-4057qib7 7655 10 been be VBN cord-005453-4057qib7 7655 11 made make VBN cord-005453-4057qib7 7655 12 by by IN cord-005453-4057qib7 7655 13 changing change VBG cord-005453-4057qib7 7655 14 our -PRON- PRP$ cord-005453-4057qib7 7655 15 procedure procedure NN cord-005453-4057qib7 7655 16 . . . cord-005453-4057qib7 7656 1 The the DT cord-005453-4057qib7 7656 2 benefit benefit NN cord-005453-4057qib7 7656 3 of of IN cord-005453-4057qib7 7656 4 changing change VBG cord-005453-4057qib7 7656 5 to to IN cord-005453-4057qib7 7656 6 a a DT cord-005453-4057qib7 7656 7 simplified simplified JJ cord-005453-4057qib7 7656 8 method method NN cord-005453-4057qib7 7656 9 of of IN cord-005453-4057qib7 7656 10 freezing freezing NN cord-005453-4057qib7 7656 11 has have VBZ cord-005453-4057qib7 7656 12 also also RB cord-005453-4057qib7 7656 13 resulted result VBN cord-005453-4057qib7 7656 14 in in IN cord-005453-4057qib7 7656 15 a a DT cord-005453-4057qib7 7656 16 reduction reduction NN cord-005453-4057qib7 7656 17 in in IN cord-005453-4057qib7 7656 18 staff staff NN cord-005453-4057qib7 7656 19 working work VBG cord-005453-4057qib7 7656 20 overtime overtime NN cord-005453-4057qib7 7656 21 . . . cord-005453-4057qib7 7657 1 More more RBR cord-005453-4057qib7 7657 2 importantly importantly RB cord-005453-4057qib7 7657 3 , , , cord-005453-4057qib7 7657 4 this this DT cord-005453-4057qib7 7657 5 simplified simplified JJ cord-005453-4057qib7 7657 6 cryopreservation cryopreservation NN cord-005453-4057qib7 7657 7 method method NN cord-005453-4057qib7 7657 8 has have VBZ cord-005453-4057qib7 7657 9 resulted result VBN cord-005453-4057qib7 7657 10 in in IN cord-005453-4057qib7 7657 11 an an DT cord-005453-4057qib7 7657 12 improvement improvement NN cord-005453-4057qib7 7657 13 in in IN cord-005453-4057qib7 7657 14 neutrophil neutrophil NN cord-005453-4057qib7 7657 15 engraftment engraftment NN cord-005453-4057qib7 7657 16 times time NNS cord-005453-4057qib7 7657 17 since since IN cord-005453-4057qib7 7657 18 changing change VBG cord-005453-4057qib7 7657 19 the the DT cord-005453-4057qib7 7657 20 cryopreservation cryopreservation NN cord-005453-4057qib7 7657 21 technique technique NN cord-005453-4057qib7 7657 22 from from IN cord-005453-4057qib7 7657 23 the the DT cord-005453-4057qib7 7657 24 previous previous JJ cord-005453-4057qib7 7657 25 method method NN cord-005453-4057qib7 7657 26 using use VBG cord-005453-4057qib7 7657 27 CRF CRF NNP cord-005453-4057qib7 7657 28 to to IN cord-005453-4057qib7 7657 29 mechanical mechanical JJ cord-005453-4057qib7 7657 30 freezing freezing NN cord-005453-4057qib7 7657 31 using use VBG cord-005453-4057qib7 7657 32 a a DT cord-005453-4057qib7 7657 33 minus minus NN cord-005453-4057qib7 7657 34 80 80 CD cord-005453-4057qib7 7657 35 o o NN cord-005453-4057qib7 7657 36 C c NN cord-005453-4057qib7 7657 37 freezer freezer NN cord-005453-4057qib7 7657 38 . . . cord-005453-4057qib7 7658 1 Disclosure disclosure NN cord-005453-4057qib7 7658 2 : : : cord-005453-4057qib7 7659 1 Nothing nothing NN cord-005453-4057qib7 7659 2 to to TO cord-005453-4057qib7 7659 3 declare declare VB cord-005453-4057qib7 7659 4 Low low JJ cord-005453-4057qib7 7659 5 doses dose NNS cord-005453-4057qib7 7659 6 of of IN cord-005453-4057qib7 7659 7 granulocytes granulocyte NNS cord-005453-4057qib7 7659 8 in in IN cord-005453-4057qib7 7659 9 the the DT cord-005453-4057qib7 7659 10 apheresis apheresis NN cord-005453-4057qib7 7659 11 product product NN cord-005453-4057qib7 7659 12 predict predict VBP cord-005453-4057qib7 7659 13 a a DT cord-005453-4057qib7 7659 14 better well JJR cord-005453-4057qib7 7659 15 outcome outcome NN cord-005453-4057qib7 7659 16 of of IN cord-005453-4057qib7 7659 17 autologous autologous JJ cord-005453-4057qib7 7659 18 hematopoietic hematopoietic JJ cord-005453-4057qib7 7659 19 stem stem NN cord-005453-4057qib7 7659 20 cell cell NN cord-005453-4057qib7 7659 21 transplantation transplantation NN cord-005453-4057qib7 7659 22 in in IN cord-005453-4057qib7 7659 23 multiple multiple JJ cord-005453-4057qib7 7659 24 myeloma myeloma NN cord-005453-4057qib7 7659 25 patients patient NNS cord-005453-4057qib7 7660 1 Background background NN cord-005453-4057qib7 7660 2 : : : cord-005453-4057qib7 7661 1 High high JJ cord-005453-4057qib7 7661 2 - - HYPH cord-005453-4057qib7 7661 3 dose dose NN cord-005453-4057qib7 7661 4 chemotherapy chemotherapy NN cord-005453-4057qib7 7661 5 with with IN cord-005453-4057qib7 7661 6 autologous autologous JJ cord-005453-4057qib7 7661 7 stem stem NN cord-005453-4057qib7 7661 8 - - HYPH cord-005453-4057qib7 7661 9 cell cell NN cord-005453-4057qib7 7661 10 transplantation transplantation NN cord-005453-4057qib7 7661 11 ( ( -LRB- cord-005453-4057qib7 7661 12 ASCT ASCT NNP cord-005453-4057qib7 7661 13 ) ) -RRB- cord-005453-4057qib7 7661 14 remains remain VBZ cord-005453-4057qib7 7661 15 the the DT cord-005453-4057qib7 7661 16 standard standard JJ cord-005453-4057qib7 7661 17 consolidation consolidation NN cord-005453-4057qib7 7661 18 therapy therapy NN cord-005453-4057qib7 7661 19 for for IN cord-005453-4057qib7 7661 20 multiple multiple JJ cord-005453-4057qib7 7661 21 myeloma myeloma NN cord-005453-4057qib7 7661 22 ( ( -LRB- cord-005453-4057qib7 7661 23 MM MM NNP cord-005453-4057qib7 7661 24 ) ) -RRB- cord-005453-4057qib7 7661 25 . . . cord-005453-4057qib7 7662 1 Peripheral peripheral JJ cord-005453-4057qib7 7662 2 blood blood NN cord-005453-4057qib7 7662 3 stem stem NN cord-005453-4057qib7 7662 4 cell cell NN cord-005453-4057qib7 7662 5 collection collection NN cord-005453-4057qib7 7662 6 may may MD cord-005453-4057qib7 7662 7 be be VB cord-005453-4057qib7 7662 8 contaminated contaminate VBN cord-005453-4057qib7 7662 9 with with IN cord-005453-4057qib7 7662 10 large large JJ cord-005453-4057qib7 7662 11 quantities quantity NNS cord-005453-4057qib7 7662 12 of of IN cord-005453-4057qib7 7662 13 granulocytes granulocyte NNS cord-005453-4057qib7 7662 14 and and CC cord-005453-4057qib7 7662 15 its -PRON- PRP$ cord-005453-4057qib7 7662 16 consequences consequence NNS cord-005453-4057qib7 7662 17 on on IN cord-005453-4057qib7 7662 18 the the DT cord-005453-4057qib7 7662 19 outcome outcome NN cord-005453-4057qib7 7662 20 of of IN cord-005453-4057qib7 7662 21 ASCT ASCT NNP cord-005453-4057qib7 7662 22 are be VBP cord-005453-4057qib7 7662 23 still still RB cord-005453-4057qib7 7662 24 unclear unclear JJ cord-005453-4057qib7 7662 25 . . . cord-005453-4057qib7 7663 1 On on IN cord-005453-4057qib7 7663 2 the the DT cord-005453-4057qib7 7663 3 other other JJ cord-005453-4057qib7 7663 4 hand hand NN cord-005453-4057qib7 7663 5 , , , cord-005453-4057qib7 7663 6 the the DT cord-005453-4057qib7 7663 7 effect effect NN cord-005453-4057qib7 7663 8 of of IN cord-005453-4057qib7 7663 9 performing perform VBG cord-005453-4057qib7 7663 10 apheresis apheresis NN cord-005453-4057qib7 7663 11 with with IN cord-005453-4057qib7 7663 12 high high JJ cord-005453-4057qib7 7663 13 levels level NNS cord-005453-4057qib7 7663 14 of of IN cord-005453-4057qib7 7663 15 monoclonal monoclonal JJ cord-005453-4057qib7 7663 16 component component NN cord-005453-4057qib7 7663 17 ( ( -LRB- cord-005453-4057qib7 7663 18 MC MC NNP cord-005453-4057qib7 7663 19 ) ) -RRB- cord-005453-4057qib7 7663 20 on on IN cord-005453-4057qib7 7663 21 outcome outcome NN cord-005453-4057qib7 7663 22 is be VBZ cord-005453-4057qib7 7663 23 unknown unknown JJ cord-005453-4057qib7 7663 24 . . . cord-005453-4057qib7 7664 1 The the DT cord-005453-4057qib7 7664 2 objective objective NN cord-005453-4057qib7 7664 3 of of IN cord-005453-4057qib7 7664 4 this this DT cord-005453-4057qib7 7664 5 study study NN cord-005453-4057qib7 7664 6 was be VBD cord-005453-4057qib7 7664 7 to to TO cord-005453-4057qib7 7664 8 analyze analyze VB cord-005453-4057qib7 7664 9 the the DT cord-005453-4057qib7 7664 10 effect effect NN cord-005453-4057qib7 7664 11 of of IN cord-005453-4057qib7 7664 12 total total JJ cord-005453-4057qib7 7664 13 nucleated nucleated JJ cord-005453-4057qib7 7664 14 cells cell NNS cord-005453-4057qib7 7664 15 ( ( -LRB- cord-005453-4057qib7 7664 16 TNC TNC NNP cord-005453-4057qib7 7664 17 ) ) -RRB- cord-005453-4057qib7 7664 18 and and CC cord-005453-4057qib7 7664 19 granulocytes granulocyte NNS cord-005453-4057qib7 7664 20 count count VBP cord-005453-4057qib7 7664 21 ( ( -LRB- cord-005453-4057qib7 7664 22 considered consider VBN cord-005453-4057qib7 7664 23 as as IN cord-005453-4057qib7 7664 24 contaminating contaminate VBG cord-005453-4057qib7 7664 25 components component NNS cord-005453-4057qib7 7664 26 of of IN cord-005453-4057qib7 7664 27 apheresis apheresis NN cord-005453-4057qib7 7664 28 products product NNS cord-005453-4057qib7 7664 29 ) ) -RRB- cord-005453-4057qib7 7664 30 as as RB cord-005453-4057qib7 7664 31 well well RB cord-005453-4057qib7 7664 32 as as IN cord-005453-4057qib7 7664 33 the the DT cord-005453-4057qib7 7664 34 influence influence NN cord-005453-4057qib7 7664 35 of of IN cord-005453-4057qib7 7664 36 MC MC NNP cord-005453-4057qib7 7664 37 in in IN cord-005453-4057qib7 7664 38 the the DT cord-005453-4057qib7 7664 39 apheresis apheresis NN cord-005453-4057qib7 7664 40 product product NN cord-005453-4057qib7 7664 41 on on IN cord-005453-4057qib7 7664 42 outcome outcome NN cord-005453-4057qib7 7664 43 of of IN cord-005453-4057qib7 7664 44 ASCT ASCT NNP cord-005453-4057qib7 7664 45 in in IN cord-005453-4057qib7 7664 46 MM MM NNP cord-005453-4057qib7 7664 47 . . . cord-005453-4057qib7 7665 1 Methods method NNS cord-005453-4057qib7 7665 2 : : : cord-005453-4057qib7 7666 1 Eighty eighty CD cord-005453-4057qib7 7666 2 - - HYPH cord-005453-4057qib7 7666 3 two two CD cord-005453-4057qib7 7666 4 patients patient NNS cord-005453-4057qib7 7666 5 diagnosed diagnose VBN cord-005453-4057qib7 7666 6 with with IN cord-005453-4057qib7 7666 7 MM MM NNP cord-005453-4057qib7 7666 8 were be VBD cord-005453-4057qib7 7666 9 mobilized mobilize VBN cord-005453-4057qib7 7666 10 with with IN cord-005453-4057qib7 7666 11 filgrastim filgrastim NN cord-005453-4057qib7 7666 12 10 10 CD cord-005453-4057qib7 7666 13 μg μg NNP cord-005453-4057qib7 7666 14 / / SYM cord-005453-4057qib7 7666 15 kg kg NNP cord-005453-4057qib7 7666 16 / / SYM cord-005453-4057qib7 7666 17 day day NN cord-005453-4057qib7 7666 18 ( ( -LRB- cord-005453-4057qib7 7666 19 plus plus CC cord-005453-4057qib7 7666 20 plerixafor plerixafor NN cord-005453-4057qib7 7666 21 if if IN cord-005453-4057qib7 7666 22 insufficient insufficient JJ cord-005453-4057qib7 7666 23 mobilization mobilization NN cord-005453-4057qib7 7666 24 of of IN cord-005453-4057qib7 7666 25 CD34 CD34 NNP cord-005453-4057qib7 7666 26 + + CC cord-005453-4057qib7 7666 27 cells cell NNS cord-005453-4057qib7 7666 28 on on IN cord-005453-4057qib7 7666 29 day day NN cord-005453-4057qib7 7666 30 4 4 CD cord-005453-4057qib7 7666 31 ) ) -RRB- cord-005453-4057qib7 7666 32 . . . cord-005453-4057qib7 7667 1 Apheresis Apheresis NNP cord-005453-4057qib7 7667 2 collection collection NN cord-005453-4057qib7 7667 3 was be VBD cord-005453-4057qib7 7667 4 performed perform VBN cord-005453-4057qib7 7667 5 with with IN cord-005453-4057qib7 7667 6 CMNc CMNc NNS cord-005453-4057qib7 7667 7 program program NN cord-005453-4057qib7 7667 8 by by IN cord-005453-4057qib7 7667 9 Spectra Spectra NNP cord-005453-4057qib7 7667 10 Optia Optia NNP cord-005453-4057qib7 7667 11 cell cell NN cord-005453-4057qib7 7667 12 separator separator NN cord-005453-4057qib7 7667 13 . . . cord-005453-4057qib7 7668 1 CD34 CD34 NNP cord-005453-4057qib7 7668 2 + + CC cord-005453-4057qib7 7668 3 count count NN cord-005453-4057qib7 7668 4 was be VBD cord-005453-4057qib7 7668 5 carried carry VBN cord-005453-4057qib7 7668 6 out out RP cord-005453-4057qib7 7668 7 according accord VBG cord-005453-4057qib7 7668 8 to to IN cord-005453-4057qib7 7668 9 ISHAGE ISHAGE NNP cord-005453-4057qib7 7668 10 protocol protocol NN cord-005453-4057qib7 7668 11 ( ( -LRB- cord-005453-4057qib7 7668 12 target target NN cord-005453-4057qib7 7668 13 : : : cord-005453-4057qib7 7668 14 ≥2x10E6 ≥2x10E6 NNP cord-005453-4057qib7 7668 15 CD34 CD34 NNP cord-005453-4057qib7 7668 16 + + CC cord-005453-4057qib7 7669 1 /Kg /Kg NNP cord-005453-4057qib7 7669 2 ) ) -RRB- cord-005453-4057qib7 7669 3 . . . cord-005453-4057qib7 7670 1 Subsequent subsequent JJ cord-005453-4057qib7 7670 2 cryopreservation cryopreservation NN cord-005453-4057qib7 7670 3 were be VBD cord-005453-4057qib7 7670 4 performed perform VBN cord-005453-4057qib7 7670 5 according accord VBG cord-005453-4057qib7 7670 6 to to IN cord-005453-4057qib7 7670 7 the the DT cord-005453-4057qib7 7670 8 local local JJ cord-005453-4057qib7 7670 9 protocol protocol NN cord-005453-4057qib7 7670 10 . . . cord-005453-4057qib7 7671 1 Results result NNS cord-005453-4057qib7 7671 2 : : : cord-005453-4057qib7 7672 1 The the DT cord-005453-4057qib7 7672 2 medians median NNS cord-005453-4057qib7 7672 3 ( ( -LRB- cord-005453-4057qib7 7672 4 range range NN cord-005453-4057qib7 7672 5 ) ) -RRB- cord-005453-4057qib7 7672 6 of of IN cord-005453-4057qib7 7672 7 collected collect VBN cord-005453-4057qib7 7672 8 CD34 CD34 NNP cord-005453-4057qib7 7672 9 + + SYM cord-005453-4057qib7 7672 10 , , , cord-005453-4057qib7 7672 11 TNC TNC NNP cord-005453-4057qib7 7672 12 and and CC cord-005453-4057qib7 7672 13 granulocytes granulocyte NNS cord-005453-4057qib7 7672 14 were be VBD cord-005453-4057qib7 7672 15 4.69x10 4.69x10 CD cord-005453-4057qib7 7672 16 6 6 CD cord-005453-4057qib7 7673 1 /Kg /Kg . cord-005453-4057qib7 7674 1 ( ( -LRB- cord-005453-4057qib7 7674 2 1.69 1.69 CD cord-005453-4057qib7 7674 3 - - SYM cord-005453-4057qib7 7674 4 15.54 15.54 CD cord-005453-4057qib7 7674 5 ) ) -RRB- cord-005453-4057qib7 7674 6 , , , cord-005453-4057qib7 7674 7 9.35x10 9.35x10 CD cord-005453-4057qib7 7674 8 8 8 CD cord-005453-4057qib7 7674 9 / / SYM cord-005453-4057qib7 7674 10 Kg Kg NNP cord-005453-4057qib7 7674 11 ( ( -LRB- cord-005453-4057qib7 7674 12 2.16 2.16 CD cord-005453-4057qib7 7674 13 - - SYM cord-005453-4057qib7 7674 14 19.66 19.66 CD cord-005453-4057qib7 7674 15 ) ) -RRB- cord-005453-4057qib7 7674 16 and and CC cord-005453-4057qib7 7674 17 13.7x10 13.7x10 CD cord-005453-4057qib7 7674 18 9 9 CD cord-005453-4057qib7 7675 1 /Kg /Kg . cord-005453-4057qib7 7676 1 ( ( -LRB- cord-005453-4057qib7 7676 2 1.4 1.4 CD cord-005453-4057qib7 7676 3 - - SYM cord-005453-4057qib7 7676 4 90.6 90.6 CD cord-005453-4057qib7 7676 5 ) ) -RRB- cord-005453-4057qib7 7676 6 , , , cord-005453-4057qib7 7676 7 respectively respectively RB cord-005453-4057qib7 7676 8 . . . cord-005453-4057qib7 7677 1 The the DT cord-005453-4057qib7 7677 2 medians median NNS cord-005453-4057qib7 7677 3 ( ( -LRB- cord-005453-4057qib7 7677 4 range range NN cord-005453-4057qib7 7677 5 ) ) -RRB- cord-005453-4057qib7 7677 6 of of IN cord-005453-4057qib7 7677 7 infused infuse VBN cord-005453-4057qib7 7677 8 CD34 CD34 NNP cord-005453-4057qib7 7677 9 + + SYM cord-005453-4057qib7 7677 10 , , , cord-005453-4057qib7 7677 11 TNC TNC NNP cord-005453-4057qib7 7677 12 and and CC cord-005453-4057qib7 7677 13 granulocytes granulocyte NNS cord-005453-4057qib7 7677 14 were be VBD cord-005453-4057qib7 7677 15 2.99x10 2.99x10 CD cord-005453-4057qib7 7677 16 6 6 CD cord-005453-4057qib7 7678 1 /Kg /Kg . cord-005453-4057qib7 7679 1 ( ( -LRB- cord-005453-4057qib7 7679 2 0.89 0.89 CD cord-005453-4057qib7 7679 3 - - SYM cord-005453-4057qib7 7679 4 10.93 10.93 CD cord-005453-4057qib7 7679 5 ) ) -RRB- cord-005453-4057qib7 7679 6 , , . cord-005453-4057qib7 7680 1 6.46x10 6.46x10 CD cord-005453-4057qib7 7681 1 8 8 CD cord-005453-4057qib7 7681 2 /Kg /kg JJ cord-005453-4057qib7 7681 3 ( ( -LRB- cord-005453-4057qib7 7681 4 1.93 1.93 CD cord-005453-4057qib7 7681 5 - - SYM cord-005453-4057qib7 7681 6 18.60 18.60 CD cord-005453-4057qib7 7681 7 ) ) -RRB- cord-005453-4057qib7 7681 8 and and CC cord-005453-4057qib7 7681 9 8.30x10 8.30x10 CD cord-005453-4057qib7 7681 10 9 9 CD cord-005453-4057qib7 7681 11 /Kg /kg NN cord-005453-4057qib7 7681 12 ( ( -LRB- cord-005453-4057qib7 7681 13 1.1 1.1 CD cord-005453-4057qib7 7681 14 - - HYPH cord-005453-4057qib7 7681 15 86.0 86.0 CD cord-005453-4057qib7 7681 16 ) ) -RRB- cord-005453-4057qib7 7681 17 , , , cord-005453-4057qib7 7681 18 respectively respectively RB cord-005453-4057qib7 7681 19 . . . cord-005453-4057qib7 7682 1 A a DT cord-005453-4057qib7 7682 2 successful successful JJ cord-005453-4057qib7 7682 3 collection collection NN cord-005453-4057qib7 7682 4 after after IN cord-005453-4057qib7 7682 5 first first JJ cord-005453-4057qib7 7682 6 line line NN cord-005453-4057qib7 7682 7 therapy therapy NN cord-005453-4057qib7 7682 8 was be VBD cord-005453-4057qib7 7682 9 performed perform VBN cord-005453-4057qib7 7682 10 in in IN cord-005453-4057qib7 7682 11 94 94 CD cord-005453-4057qib7 7682 12 % % NN cord-005453-4057qib7 7682 13 of of IN cord-005453-4057qib7 7682 14 patients patient NNS cord-005453-4057qib7 7682 15 . . . cord-005453-4057qib7 7683 1 Treatment treatment NN cord-005453-4057qib7 7683 2 for for IN cord-005453-4057qib7 7683 3 MM MM NNP cord-005453-4057qib7 7683 4 was be VBD cord-005453-4057qib7 7683 5 continued continue VBN cord-005453-4057qib7 7683 6 after after IN cord-005453-4057qib7 7683 7 carrying carry VBG cord-005453-4057qib7 7683 8 out out RP cord-005453-4057qib7 7683 9 apheresis apheresis NN cord-005453-4057qib7 7683 10 in in IN cord-005453-4057qib7 7683 11 40 40 CD cord-005453-4057qib7 7683 12 % % NN cord-005453-4057qib7 7683 13 of of IN cord-005453-4057qib7 7683 14 patients patient NNS cord-005453-4057qib7 7683 15 , , , cord-005453-4057qib7 7683 16 as as IN cord-005453-4057qib7 7683 17 per per IN cord-005453-4057qib7 7683 18 protocol protocol NN cord-005453-4057qib7 7683 19 . . . cord-005453-4057qib7 7684 1 A a DT cord-005453-4057qib7 7684 2 significant significant JJ cord-005453-4057qib7 7684 3 reduction reduction NN cord-005453-4057qib7 7684 4 of of IN cord-005453-4057qib7 7684 5 MC MC NNP cord-005453-4057qib7 7684 6 was be VBD cord-005453-4057qib7 7684 7 observed observe VBN cord-005453-4057qib7 7684 8 prior prior RB cord-005453-4057qib7 7684 9 to to IN cord-005453-4057qib7 7684 10 ASCT ASCT NNP cord-005453-4057qib7 7684 11 , , , cord-005453-4057qib7 7684 12 indicating indicate VBG cord-005453-4057qib7 7684 13 a a DT cord-005453-4057qib7 7684 14 further further JJ cord-005453-4057qib7 7684 15 improvement improvement NN cord-005453-4057qib7 7684 16 in in IN cord-005453-4057qib7 7684 17 responses response NNS cord-005453-4057qib7 7684 18 after after IN cord-005453-4057qib7 7684 19 apheresis apheresis NN cord-005453-4057qib7 7684 20 ( ( -LRB- cord-005453-4057qib7 7684 21 p=0.005 p=0.005 NNP cord-005453-4057qib7 7684 22 ) ) -RRB- cord-005453-4057qib7 7684 23 . . . cord-005453-4057qib7 7685 1 An an DT cord-005453-4057qib7 7685 2 optimal optimal JJ cord-005453-4057qib7 7685 3 response response NN cord-005453-4057qib7 7685 4 ( ( -LRB- cord-005453-4057qib7 7685 5 CR CR NNP cord-005453-4057qib7 7685 6 or or CC cord-005453-4057qib7 7685 7 VGPR VGPR NNP cord-005453-4057qib7 7685 8 ) ) -RRB- cord-005453-4057qib7 7685 9 at at IN cord-005453-4057qib7 7685 10 the the DT cord-005453-4057qib7 7685 11 time time NN cord-005453-4057qib7 7685 12 of of IN cord-005453-4057qib7 7685 13 apheresis apheresis NN cord-005453-4057qib7 7685 14 was be VBD cord-005453-4057qib7 7685 15 achieved achieve VBN cord-005453-4057qib7 7685 16 in in IN cord-005453-4057qib7 7685 17 45 45 CD cord-005453-4057qib7 7685 18 % % NN cord-005453-4057qib7 7685 19 of of IN cord-005453-4057qib7 7685 20 patients patient NNS cord-005453-4057qib7 7685 21 and and CC cord-005453-4057qib7 7685 22 a a DT cord-005453-4057qib7 7685 23 suboptimal suboptimal JJ cord-005453-4057qib7 7685 24 response response NN cord-005453-4057qib7 7685 25 ( ( -LRB- cord-005453-4057qib7 7685 26 partial partial JJ cord-005453-4057qib7 7685 27 or or CC cord-005453-4057qib7 7685 28 minimal minimal JJ cord-005453-4057qib7 7685 29 response response NN cord-005453-4057qib7 7685 30 ) ) -RRB- cord-005453-4057qib7 7685 31 was be VBD cord-005453-4057qib7 7685 32 observed observe VBN cord-005453-4057qib7 7685 33 in in IN cord-005453-4057qib7 7685 34 the the DT cord-005453-4057qib7 7685 35 remaining remain VBG cord-005453-4057qib7 7685 36 55 55 CD cord-005453-4057qib7 7685 37 % % NN cord-005453-4057qib7 7685 38 . . . cord-005453-4057qib7 7686 1 Undergoing undergo VBG cord-005453-4057qib7 7686 2 apheresis apheresis NN cord-005453-4057qib7 7686 3 in in IN cord-005453-4057qib7 7686 4 optimal optimal JJ cord-005453-4057qib7 7686 5 response response NN cord-005453-4057qib7 7686 6 did do VBD cord-005453-4057qib7 7686 7 not not RB cord-005453-4057qib7 7686 8 result result VB cord-005453-4057qib7 7686 9 in in IN cord-005453-4057qib7 7686 10 lower low JJR cord-005453-4057qib7 7686 11 number number NN cord-005453-4057qib7 7686 12 of of IN cord-005453-4057qib7 7686 13 TNC TNC NNP cord-005453-4057qib7 7686 14 or or CC cord-005453-4057qib7 7686 15 granulocytes granulocyte NNS cord-005453-4057qib7 7686 16 in in IN cord-005453-4057qib7 7686 17 the the DT cord-005453-4057qib7 7686 18 harvest harvest NN cord-005453-4057qib7 7686 19 . . . cord-005453-4057qib7 7687 1 The the DT cord-005453-4057qib7 7687 2 subtype subtype NN cord-005453-4057qib7 7687 3 of of IN cord-005453-4057qib7 7687 4 MC MC NNP cord-005453-4057qib7 7687 5 did do VBD cord-005453-4057qib7 7687 6 not not RB cord-005453-4057qib7 7687 7 influence influence VB cord-005453-4057qib7 7687 8 on on IN cord-005453-4057qib7 7687 9 the the DT cord-005453-4057qib7 7687 10 number number NN cord-005453-4057qib7 7687 11 of of IN cord-005453-4057qib7 7687 12 TNC TNC NNP cord-005453-4057qib7 7687 13 and and CC cord-005453-4057qib7 7687 14 granulocytes granulocyte NNS cord-005453-4057qib7 7687 15 in in IN cord-005453-4057qib7 7687 16 the the DT cord-005453-4057qib7 7687 17 product product NN cord-005453-4057qib7 7687 18 of of IN cord-005453-4057qib7 7687 19 apheresis apheresis NN cord-005453-4057qib7 7687 20 . . . cord-005453-4057qib7 7688 1 No no DT cord-005453-4057qib7 7688 2 differences difference NNS cord-005453-4057qib7 7688 3 in in IN cord-005453-4057qib7 7688 4 collected collect VBN cord-005453-4057qib7 7688 5 TNC TNC NNP cord-005453-4057qib7 7688 6 and and CC cord-005453-4057qib7 7688 7 granulocytes granulocyte NNS cord-005453-4057qib7 7688 8 were be VBD cord-005453-4057qib7 7688 9 observed observe VBN cord-005453-4057qib7 7688 10 when when WRB cord-005453-4057qib7 7688 11 plerixafor plerixafor NN cord-005453-4057qib7 7688 12 was be VBD cord-005453-4057qib7 7688 13 used use VBN cord-005453-4057qib7 7688 14 as as IN cord-005453-4057qib7 7688 15 mobilizing mobilize VBG cord-005453-4057qib7 7688 16 agent agent NN cord-005453-4057qib7 7688 17 . . . cord-005453-4057qib7 7689 1 The the DT cord-005453-4057qib7 7689 2 type type NN cord-005453-4057qib7 7689 3 of of IN cord-005453-4057qib7 7689 4 chemotherapy chemotherapy NN cord-005453-4057qib7 7689 5 given give VBN cord-005453-4057qib7 7689 6 prior prior RB cord-005453-4057qib7 7689 7 the the DT cord-005453-4057qib7 7689 8 apheresis apheresis NN cord-005453-4057qib7 7689 9 did do VBD cord-005453-4057qib7 7689 10 not not RB cord-005453-4057qib7 7689 11 have have VB cord-005453-4057qib7 7689 12 influence influence NN cord-005453-4057qib7 7689 13 on on IN cord-005453-4057qib7 7689 14 the the DT cord-005453-4057qib7 7689 15 characteristics characteristic NNS cord-005453-4057qib7 7689 16 of of IN cord-005453-4057qib7 7689 17 the the DT cord-005453-4057qib7 7689 18 apheresis apheresis NN cord-005453-4057qib7 7689 19 product product NN cord-005453-4057qib7 7689 20 . . . cord-005453-4057qib7 7690 1 A a DT cord-005453-4057qib7 7690 2 significant significant JJ cord-005453-4057qib7 7690 3 improvement improvement NN cord-005453-4057qib7 7690 4 in in IN cord-005453-4057qib7 7690 5 overall overall JJ cord-005453-4057qib7 7690 6 survival survival NN cord-005453-4057qib7 7690 7 ( ( -LRB- cord-005453-4057qib7 7690 8 OS os NN cord-005453-4057qib7 7690 9 ) ) -RRB- cord-005453-4057qib7 7690 10 probability probability NN cord-005453-4057qib7 7690 11 ( ( -LRB- cord-005453-4057qib7 7690 12 95%CI 95%ci CD cord-005453-4057qib7 7690 13 ) ) -RRB- cord-005453-4057qib7 7690 14 was be VBD cord-005453-4057qib7 7690 15 observed observe VBN cord-005453-4057qib7 7690 16 when when WRB cord-005453-4057qib7 7690 17 low low JJ cord-005453-4057qib7 7690 18 TNC TNC NNP cord-005453-4057qib7 7690 19 ( ( -LRB- cord-005453-4057qib7 7690 20 < < NNP cord-005453-4057qib7 7690 21 6.46x10 6.46x10 CD cord-005453-4057qib7 7690 22 8 8 CD cord-005453-4057qib7 7690 23 Figure figure NN cord-005453-4057qib7 7690 24 1A 1a NN cord-005453-4057qib7 7690 25 ) ) -RRB- cord-005453-4057qib7 7690 26 . . . cord-005453-4057qib7 7691 1 Lower low JJR cord-005453-4057qib7 7691 2 incidence incidence NN cord-005453-4057qib7 7691 3 of of IN cord-005453-4057qib7 7691 4 relapse relapse NN cord-005453-4057qib7 7691 5 ( ( -LRB- cord-005453-4057qib7 7691 6 p=0.044 p=0.044 NNS cord-005453-4057qib7 7691 7 ) ) -RRB- cord-005453-4057qib7 7692 1 ( ( -LRB- cord-005453-4057qib7 7692 2 Figure figure NN cord-005453-4057qib7 7692 3 1B 1b CD cord-005453-4057qib7 7692 4 ) ) -RRB- cord-005453-4057qib7 7692 5 and and CC cord-005453-4057qib7 7692 6 non non JJ cord-005453-4057qib7 7692 7 - - JJ cord-005453-4057qib7 7692 8 relapse relapse JJ cord-005453-4057qib7 7692 9 mortality mortality NN cord-005453-4057qib7 7692 10 ( ( -LRB- cord-005453-4057qib7 7692 11 p=0.040 p=0.040 NNP cord-005453-4057qib7 7692 12 ) ) -RRB- cord-005453-4057qib7 7692 13 was be VBD cord-005453-4057qib7 7692 14 observed observe VBN cord-005453-4057qib7 7692 15 in in IN cord-005453-4057qib7 7692 16 patients patient NNS cord-005453-4057qib7 7692 17 who who WP cord-005453-4057qib7 7692 18 received receive VBD cord-005453-4057qib7 7692 19 low low JJ cord-005453-4057qib7 7692 20 granulocyte granulocyte NN cord-005453-4057qib7 7692 21 count count NN cord-005453-4057qib7 7692 22 in in IN cord-005453-4057qib7 7692 23 the the DT cord-005453-4057qib7 7692 24 graft graft NN cord-005453-4057qib7 7692 25 . . . cord-005453-4057qib7 7693 1 No no DT cord-005453-4057qib7 7693 2 significant significant JJ cord-005453-4057qib7 7693 3 correlation correlation NN cord-005453-4057qib7 7693 4 was be VBD cord-005453-4057qib7 7693 5 observed observe VBN cord-005453-4057qib7 7693 6 between between IN cord-005453-4057qib7 7693 7 the the DT cord-005453-4057qib7 7693 8 time time NN cord-005453-4057qib7 7693 9 of of IN cord-005453-4057qib7 7693 10 engraftment engraftment NN cord-005453-4057qib7 7693 11 and and CC cord-005453-4057qib7 7693 12 the the DT cord-005453-4057qib7 7693 13 number number NN cord-005453-4057qib7 7693 14 of of IN cord-005453-4057qib7 7693 15 TNC TNC NNP cord-005453-4057qib7 7693 16 or or CC cord-005453-4057qib7 7693 17 granulocytes granulocyte NNS cord-005453-4057qib7 7693 18 infused infuse VBN cord-005453-4057qib7 7693 19 . . . cord-005453-4057qib7 7694 1 Similarly similarly RB cord-005453-4057qib7 7694 2 , , , cord-005453-4057qib7 7694 3 no no DT cord-005453-4057qib7 7694 4 increase increase NN cord-005453-4057qib7 7694 5 in in IN cord-005453-4057qib7 7694 6 the the DT cord-005453-4057qib7 7694 7 frequency frequency NN cord-005453-4057qib7 7694 8 of of IN cord-005453-4057qib7 7694 9 the the DT cord-005453-4057qib7 7694 10 engraftment engraftment NNP cord-005453-4057qib7 7694 11 syndrome syndrome NNP cord-005453-4057qib7 7694 12 was be VBD cord-005453-4057qib7 7694 13 observed observe VBN cord-005453-4057qib7 7694 14 when when WRB cord-005453-4057qib7 7694 15 higher high JJR cord-005453-4057qib7 7694 16 number number NN cord-005453-4057qib7 7694 17 of of IN cord-005453-4057qib7 7694 18 TNC TNC NNP cord-005453-4057qib7 7694 19 or or CC cord-005453-4057qib7 7694 20 granulocytes granulocyte NNS cord-005453-4057qib7 7694 21 were be VBD cord-005453-4057qib7 7694 22 infused infuse VBN cord-005453-4057qib7 7694 23 . . . cord-005453-4057qib7 7695 1 Conclusions conclusion NNS cord-005453-4057qib7 7695 2 : : : cord-005453-4057qib7 7696 1 In in IN cord-005453-4057qib7 7696 2 our -PRON- PRP$ cord-005453-4057qib7 7696 3 series series NN cord-005453-4057qib7 7696 4 , , , cord-005453-4057qib7 7696 5 low low JJ cord-005453-4057qib7 7696 6 doses dose NNS cord-005453-4057qib7 7696 7 of of IN cord-005453-4057qib7 7696 8 granulocytes granulocyte NNS cord-005453-4057qib7 7696 9 in in IN cord-005453-4057qib7 7696 10 the the DT cord-005453-4057qib7 7696 11 product product NN cord-005453-4057qib7 7696 12 of of IN cord-005453-4057qib7 7696 13 apheresis apheresis NN cord-005453-4057qib7 7696 14 predicted predict VBD cord-005453-4057qib7 7696 15 a a DT cord-005453-4057qib7 7696 16 better well JJR cord-005453-4057qib7 7696 17 outcome outcome NN cord-005453-4057qib7 7696 18 of of IN cord-005453-4057qib7 7696 19 ASCT ASCT NNP cord-005453-4057qib7 7696 20 in in IN cord-005453-4057qib7 7696 21 MM MM NNP cord-005453-4057qib7 7696 22 patients patient NNS cord-005453-4057qib7 7696 23 . . . cord-005453-4057qib7 7697 1 The the DT cord-005453-4057qib7 7697 2 amount amount NN cord-005453-4057qib7 7697 3 of of IN cord-005453-4057qib7 7697 4 MC MC NNP cord-005453-4057qib7 7697 5 at at IN cord-005453-4057qib7 7697 6 the the DT cord-005453-4057qib7 7697 7 time time NN cord-005453-4057qib7 7697 8 of of IN cord-005453-4057qib7 7697 9 apheresis apheresis NN cord-005453-4057qib7 7697 10 did do VBD cord-005453-4057qib7 7697 11 not not RB cord-005453-4057qib7 7697 12 have have VB cord-005453-4057qib7 7697 13 influence influence NN cord-005453-4057qib7 7697 14 in in IN cord-005453-4057qib7 7697 15 the the DT cord-005453-4057qib7 7697 16 characteristics characteristic NNS cord-005453-4057qib7 7697 17 of of IN cord-005453-4057qib7 7697 18 the the DT cord-005453-4057qib7 7697 19 harvest harvest NN cord-005453-4057qib7 7697 20 . . . cord-005453-4057qib7 7698 1 Efforts effort NNS cord-005453-4057qib7 7698 2 for for IN cord-005453-4057qib7 7698 3 avoiding avoid VBG cord-005453-4057qib7 7698 4 contamination contamination NN cord-005453-4057qib7 7698 5 in in IN cord-005453-4057qib7 7698 6 grafts graft NNS cord-005453-4057qib7 7698 7 are be VBP cord-005453-4057qib7 7698 8 important important JJ cord-005453-4057qib7 7698 9 for for IN cord-005453-4057qib7 7698 10 its -PRON- PRP$ cord-005453-4057qib7 7698 11 impact impact NN cord-005453-4057qib7 7698 12 on on IN cord-005453-4057qib7 7698 13 outcome outcome NN cord-005453-4057qib7 7698 14 of of IN cord-005453-4057qib7 7698 15 ASCT ASCT NNP cord-005453-4057qib7 7698 16 in in IN cord-005453-4057qib7 7698 17 MM MM NNP cord-005453-4057qib7 7698 18 patients patient NNS cord-005453-4057qib7 7698 19 . . . cord-005453-4057qib7 7699 1 Disclosure disclosure NN cord-005453-4057qib7 7699 2 : : : cord-005453-4057qib7 7699 3 DKMS DKMS NNP cord-005453-4057qib7 7699 4 Foundation Foundation NNP cord-005453-4057qib7 7699 5 , , , cord-005453-4057qib7 7699 6 PI14/01971 PI14/01971 NNP cord-005453-4057qib7 7700 1 ( ( -LRB- cord-005453-4057qib7 7700 2 Instituto Instituto NNP cord-005453-4057qib7 7700 3 Carlos Carlos NNP cord-005453-4057qib7 7700 4 III III NNP cord-005453-4057qib7 7700 5 ) ) -RRB- cord-005453-4057qib7 7701 1 and and CC cord-005453-4057qib7 7701 2 SGR288 SGR288 NNP cord-005453-4057qib7 7701 3 ( ( -LRB- cord-005453-4057qib7 7701 4 GRC GRC NNP cord-005453-4057qib7 7701 5 ) ) -RRB- cord-005453-4057qib7 7701 6 , , , cord-005453-4057qib7 7701 7 Generalitat Generalitat NNP cord-005453-4057qib7 7701 8 de de NNP cord-005453-4057qib7 7701 9 Catalunya Catalunya NNP cord-005453-4057qib7 7701 10 . . . cord-005453-4057qib7 7702 1 Background background NN cord-005453-4057qib7 7702 2 : : : cord-005453-4057qib7 7703 1 Our -PRON- PRP$ cord-005453-4057qib7 7703 2 initial initial JJ cord-005453-4057qib7 7703 3 experience experience NN cord-005453-4057qib7 7703 4 ( ( -LRB- cord-005453-4057qib7 7703 5 from from IN cord-005453-4057qib7 7703 6 2012 2012 CD cord-005453-4057qib7 7703 7 to to IN cord-005453-4057qib7 7703 8 2017 2017 CD cord-005453-4057qib7 7703 9 years year NNS cord-005453-4057qib7 7703 10 ) ) -RRB- cord-005453-4057qib7 7703 11 with with IN cord-005453-4057qib7 7703 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 7703 13 stem stem NN cord-005453-4057qib7 7703 14 cell cell NN cord-005453-4057qib7 7703 15 transplantation transplantation NN cord-005453-4057qib7 7703 16 ( ( -LRB- cord-005453-4057qib7 7703 17 HSCT HSCT NNP cord-005453-4057qib7 7703 18 ) ) -RRB- cord-005453-4057qib7 7703 19 from from IN cord-005453-4057qib7 7703 20 MUD mud NN cord-005453-4057qib7 7703 21 with with IN cord-005453-4057qib7 7703 22 TCRαβ+/CD19 tcrαβ+/cd19 NN cord-005453-4057qib7 7703 23 + + CC cord-005453-4057qib7 7703 24 graft graft NN cord-005453-4057qib7 7703 25 depletion depletion NN cord-005453-4057qib7 7703 26 in in IN cord-005453-4057qib7 7703 27 patients patient NNS cord-005453-4057qib7 7703 28 with with IN cord-005453-4057qib7 7703 29 CGD CGD NNP cord-005453-4057qib7 7703 30 showed show VBD cord-005453-4057qib7 7703 31 high high JJ cord-005453-4057qib7 7703 32 rate rate NN cord-005453-4057qib7 7703 33 of of IN cord-005453-4057qib7 7703 34 secondary secondary JJ cord-005453-4057qib7 7703 35 graft graft NN cord-005453-4057qib7 7703 36 dysfunction dysfunction NN cord-005453-4057qib7 7703 37 , , , cord-005453-4057qib7 7703 38 the the DT cord-005453-4057qib7 7703 39 incident incident NN cord-005453-4057qib7 7703 40 of of IN cord-005453-4057qib7 7703 41 graft graft NN cord-005453-4057qib7 7703 42 rejection rejection NN cord-005453-4057qib7 7703 43 was be VBD cord-005453-4057qib7 7703 44 29 29 CD cord-005453-4057qib7 7703 45 % % NN cord-005453-4057qib7 7703 46 . . . cord-005453-4057qib7 7704 1 To to TO cord-005453-4057qib7 7704 2 improve improve VB cord-005453-4057qib7 7704 3 the the DT cord-005453-4057qib7 7704 4 outcome outcome NN cord-005453-4057qib7 7704 5 , , , cord-005453-4057qib7 7704 6 we -PRON- PRP cord-005453-4057qib7 7704 7 hypothesized hypothesize VBD cord-005453-4057qib7 7704 8 that that IN cord-005453-4057qib7 7704 9 the the DT cord-005453-4057qib7 7704 10 use use NN cord-005453-4057qib7 7704 11 of of IN cord-005453-4057qib7 7704 12 plerixafor plerixafor NN cord-005453-4057qib7 7704 13 and and CC cord-005453-4057qib7 7704 14 G G NNP cord-005453-4057qib7 7704 15 - - HYPH cord-005453-4057qib7 7704 16 CSF CSF NNP cord-005453-4057qib7 7704 17 as as IN cord-005453-4057qib7 7704 18 additional additional JJ cord-005453-4057qib7 7704 19 agents agent NNS cord-005453-4057qib7 7704 20 in in IN cord-005453-4057qib7 7704 21 conditioning conditioning NN cord-005453-4057qib7 7704 22 regimen regimen NN cord-005453-4057qib7 7704 23 would would MD cord-005453-4057qib7 7704 24 offers offer VBZ cord-005453-4057qib7 7704 25 advantages advantage NNS cord-005453-4057qib7 7704 26 and and CC cord-005453-4057qib7 7704 27 better well JJR cord-005453-4057qib7 7704 28 outcomes outcome NNS cord-005453-4057qib7 7704 29 . . . cord-005453-4057qib7 7705 1 This this DT cord-005453-4057qib7 7705 2 trial trial NN cord-005453-4057qib7 7705 3 was be VBD cord-005453-4057qib7 7705 4 registered register VBN cord-005453-4057qib7 7705 5 at at IN cord-005453-4057qib7 7705 6 www.clinicaltrials.gov www.clinicaltrials.gov NNP cord-005453-4057qib7 7705 7 ( ( -LRB- cord-005453-4057qib7 7705 8 NCT03547830 NCT03547830 NNP cord-005453-4057qib7 7705 9 ) ) -RRB- cord-005453-4057qib7 7705 10 Methods method NNS cord-005453-4057qib7 7705 11 : : : cord-005453-4057qib7 7705 12 Between between IN cord-005453-4057qib7 7705 13 April April NNP cord-005453-4057qib7 7705 14 2018 2018 CD cord-005453-4057qib7 7705 15 and and CC cord-005453-4057qib7 7705 16 September September NNP cord-005453-4057qib7 7705 17 2018 2018 CD cord-005453-4057qib7 7705 18 , , , cord-005453-4057qib7 7705 19 5 5 CD cord-005453-4057qib7 7705 20 patients patient NNS cord-005453-4057qib7 7705 21 with with IN cord-005453-4057qib7 7705 22 CGD CGD NNP cord-005453-4057qib7 7705 23 underwent undergo VBD cord-005453-4057qib7 7705 24 allogeneic allogeneic JJ cord-005453-4057qib7 7705 25 HSCTs hsct NNS cord-005453-4057qib7 7705 26 from from IN cord-005453-4057qib7 7705 27 mached mached JJ cord-005453-4057qib7 7705 28 unrelated unrelated JJ cord-005453-4057qib7 7705 29 donors donor NNS cord-005453-4057qib7 7705 30 with with IN cord-005453-4057qib7 7705 31 TCRαβ TCRαβ NNP cord-005453-4057qib7 7705 32 + + CC cord-005453-4057qib7 7705 33 / / . cord-005453-4057qib7 7706 1 CD19 CD19 NNP cord-005453-4057qib7 7706 2 + + CC cord-005453-4057qib7 7706 3 graft graft NN cord-005453-4057qib7 7706 4 . . . cord-005453-4057qib7 7707 1 The the DT cord-005453-4057qib7 7707 2 conditioning conditioning NN cord-005453-4057qib7 7707 3 regimen regimen NN cord-005453-4057qib7 7707 4 included include VBD cord-005453-4057qib7 7707 5 -treosulfan -treosulfan NN cord-005453-4057qib7 7707 6 42 42 CD cord-005453-4057qib7 7707 7 g g NN cord-005453-4057qib7 7707 8 / / SYM cord-005453-4057qib7 7707 9 m2 m2 NNP cord-005453-4057qib7 7707 10 , , , cord-005453-4057qib7 7707 11 fludarabine fludarabine JJ cord-005453-4057qib7 7707 12 150 150 CD cord-005453-4057qib7 7707 13 mg mg NNP cord-005453-4057qib7 7707 14 / / SYM cord-005453-4057qib7 7707 15 m2 m2 NNP cord-005453-4057qib7 7707 16 , , , cord-005453-4057qib7 7707 17 thiotepa thiotepa JJ cord-005453-4057qib7 7707 18 10 10 CD cord-005453-4057qib7 7707 19 mg mg NNP cord-005453-4057qib7 7707 20 / / SYM cord-005453-4057qib7 7707 21 kg kg NNP cord-005453-4057qib7 7707 22 , , , cord-005453-4057qib7 7707 23 G G NNP cord-005453-4057qib7 7707 24 - - HYPH cord-005453-4057qib7 7707 25 CSF CSF NNP cord-005453-4057qib7 7707 26 50 50 CD cord-005453-4057qib7 7707 27 mcg mcg NNP cord-005453-4057qib7 7707 28 / / SYM cord-005453-4057qib7 7707 29 kg kg NN cord-005453-4057qib7 7707 30 and and CC cord-005453-4057qib7 7707 31 plerixafor plerixafor NN cord-005453-4057qib7 7707 32 720 720 CD cord-005453-4057qib7 7707 33 mcg mcg NN cord-005453-4057qib7 7707 34 / / SYM cord-005453-4057qib7 7707 35 kg kg NNP cord-005453-4057qib7 7707 36 . . . cord-005453-4057qib7 7708 1 All all DT cord-005453-4057qib7 7708 2 patients patient NNS cord-005453-4057qib7 7708 3 received receive VBD cord-005453-4057qib7 7708 4 rabbit rabbit NN cord-005453-4057qib7 7708 5 ATG ATG NNP cord-005453-4057qib7 7708 6 -Timoglobulin -Timoglobulin . cord-005453-4057qib7 7709 1 ® ® VB cord-005453-4057qib7 7709 2 ( ( -LRB- cord-005453-4057qib7 7709 3 " " `` cord-005453-4057qib7 7709 4 Genzyme Genzyme NNP cord-005453-4057qib7 7709 5 Europe Europe NNP cord-005453-4057qib7 7709 6 B.V. B.V. NNP cord-005453-4057qib7 7709 7 " " '' cord-005453-4057qib7 7709 8 , , , cord-005453-4057qib7 7709 9 The the DT cord-005453-4057qib7 7709 10 Netherlands Netherlands NNP cord-005453-4057qib7 7709 11 ) ) -RRB- cord-005453-4057qib7 7710 1 5 5 CD cord-005453-4057qib7 7710 2 mg mg NNP cord-005453-4057qib7 7710 3 / / SYM cord-005453-4057qib7 7710 4 kg kg NNP cord-005453-4057qib7 7710 5 for for IN cord-005453-4057qib7 7710 6 serotherapy serotherapy NNP cord-005453-4057qib7 7710 7 . . . cord-005453-4057qib7 7711 1 In in IN cord-005453-4057qib7 7711 2 all all DT cord-005453-4057qib7 7711 3 cases case NNS cord-005453-4057qib7 7711 4 , , , cord-005453-4057qib7 7711 5 TCRab TCRab NNP cord-005453-4057qib7 7711 6 + + CC cord-005453-4057qib7 7711 7 /CD19 /cd19 NN cord-005453-4057qib7 7711 8 + + CC cord-005453-4057qib7 7711 9 graft graft NN cord-005453-4057qib7 7711 10 depletion depletion NN cord-005453-4057qib7 7711 11 was be VBD cord-005453-4057qib7 7711 12 used use VBN cord-005453-4057qib7 7711 13 with with IN cord-005453-4057qib7 7711 14 the the DT cord-005453-4057qib7 7711 15 immunemagnetic immunemagnetic JJ cord-005453-4057qib7 7711 16 method method NN cord-005453-4057qib7 7711 17 ( ( -LRB- cord-005453-4057qib7 7711 18 Miltenyi Miltenyi NNP cord-005453-4057qib7 7711 19 Biotec Biotec NNP cord-005453-4057qib7 7711 20 , , , cord-005453-4057qib7 7711 21 Bergisch Bergisch NNP cord-005453-4057qib7 7711 22 Gladbach Gladbach NNP cord-005453-4057qib7 7711 23 , , , cord-005453-4057qib7 7711 24 Germany Germany NNP cord-005453-4057qib7 7711 25 ) ) -RRB- cord-005453-4057qib7 7711 26 according accord VBG cord-005453-4057qib7 7711 27 to to IN cord-005453-4057qib7 7711 28 the the DT cord-005453-4057qib7 7711 29 manufacturer manufacturer NN cord-005453-4057qib7 7711 30 's 's POS cord-005453-4057qib7 7711 31 instructions instruction NNS cord-005453-4057qib7 7711 32 . . . cord-005453-4057qib7 7712 1 Stem stem JJ cord-005453-4057qib7 7712 2 cell cell NN cord-005453-4057qib7 7712 3 source source NN cord-005453-4057qib7 7712 4 was be VBD cord-005453-4057qib7 7712 5 G G NNP cord-005453-4057qib7 7712 6 - - HYPH cord-005453-4057qib7 7712 7 CSF CSF NNP cord-005453-4057qib7 7712 8 mobilized mobilize VBD cord-005453-4057qib7 7712 9 peripheral peripheral JJ cord-005453-4057qib7 7712 10 blood blood NN cord-005453-4057qib7 7712 11 stem stem NN cord-005453-4057qib7 7712 12 cells cell NNS cord-005453-4057qib7 7712 13 in in IN cord-005453-4057qib7 7712 14 all all DT cord-005453-4057qib7 7712 15 cases case NNS cord-005453-4057qib7 7712 16 . . . cord-005453-4057qib7 7713 1 Posttransplant Posttransplant NNP cord-005453-4057qib7 7713 2 GVHD GVHD NNP cord-005453-4057qib7 7713 3 prophylaxis prophylaxis NN cord-005453-4057qib7 7713 4 was be VBD cord-005453-4057qib7 7713 5 not not RB cord-005453-4057qib7 7713 6 performed perform VBN cord-005453-4057qib7 7713 7 . . . cord-005453-4057qib7 7714 1 Minimal minimal JJ cord-005453-4057qib7 7714 2 follow follow NN cord-005453-4057qib7 7714 3 up up RP cord-005453-4057qib7 7714 4 was be VBD cord-005453-4057qib7 7714 5 90 90 CD cord-005453-4057qib7 7714 6 days day NNS cord-005453-4057qib7 7714 7 after after IN cord-005453-4057qib7 7714 8 HSCT HSCT NNP cord-005453-4057qib7 7714 9 . . . cord-005453-4057qib7 7715 1 Results result NNS cord-005453-4057qib7 7715 2 : : : cord-005453-4057qib7 7716 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 7716 2 and and CC cord-005453-4057qib7 7716 3 platelet platelet NN cord-005453-4057qib7 7716 4 engraftment engraftment NN cord-005453-4057qib7 7716 5 occurred occur VBD cord-005453-4057qib7 7716 6 at at IN cord-005453-4057qib7 7716 7 12 12 CD cord-005453-4057qib7 7716 8 - - SYM cord-005453-4057qib7 7716 9 17 17 CD cord-005453-4057qib7 7716 10 days day NNS cord-005453-4057qib7 7716 11 post post NN cord-005453-4057qib7 7716 12 - - JJ cord-005453-4057qib7 7716 13 HSCT HSCT NNP cord-005453-4057qib7 7716 14 in in IN cord-005453-4057qib7 7716 15 all all DT cord-005453-4057qib7 7716 16 patients patient NNS cord-005453-4057qib7 7716 17 . . . cord-005453-4057qib7 7717 1 3 3 CD cord-005453-4057qib7 7717 2 patients patient NNS cord-005453-4057qib7 7717 3 had have VBD cord-005453-4057qib7 7717 4 full full JJ cord-005453-4057qib7 7717 5 donor donor NN cord-005453-4057qib7 7717 6 chimerism chimerism NN cord-005453-4057qib7 7717 7 in in IN cord-005453-4057qib7 7717 8 whole whole JJ cord-005453-4057qib7 7717 9 blood blood NN cord-005453-4057qib7 7717 10 and and CC cord-005453-4057qib7 7717 11 in in IN cord-005453-4057qib7 7717 12 2 2 CD cord-005453-4057qib7 7717 13 cases case NNS cord-005453-4057qib7 7717 14 we -PRON- PRP cord-005453-4057qib7 7717 15 observed observe VBD cord-005453-4057qib7 7717 16 predominantly predominantly RB cord-005453-4057qib7 7717 17 donor donor NN cord-005453-4057qib7 7717 18 mixed mix VBN cord-005453-4057qib7 7717 19 chimerism chimerism NN cord-005453-4057qib7 7717 20 at at IN cord-005453-4057qib7 7717 21 last last JJ cord-005453-4057qib7 7717 22 follow follow VB cord-005453-4057qib7 7717 23 up up RP cord-005453-4057qib7 7717 24 . . . cord-005453-4057qib7 7718 1 All all DT cord-005453-4057qib7 7718 2 patients patient NNS cord-005453-4057qib7 7718 3 had have VBD cord-005453-4057qib7 7718 4 full full JJ cord-005453-4057qib7 7718 5 donor donor NN cord-005453-4057qib7 7718 6 chimerism chimerism NN cord-005453-4057qib7 7718 7 in in IN cord-005453-4057qib7 7718 8 CD15 CD15 NNP cord-005453-4057qib7 7718 9 + + CC cord-005453-4057qib7 7718 10 compartment compartment NN cord-005453-4057qib7 7718 11 and and CC cord-005453-4057qib7 7718 12 mixed mixed JJ cord-005453-4057qib7 7718 13 chimerism chimerism NN cord-005453-4057qib7 7718 14 in in IN cord-005453-4057qib7 7718 15 CD3 CD3 NNP cord-005453-4057qib7 7718 16 + + CC cord-005453-4057qib7 7718 17 lineage lineage NN cord-005453-4057qib7 7718 18 , , , cord-005453-4057qib7 7718 19 but but CC cord-005453-4057qib7 7718 20 it -PRON- PRP cord-005453-4057qib7 7718 21 stable stable JJ cord-005453-4057qib7 7718 22 without without IN cord-005453-4057qib7 7718 23 any any DT cord-005453-4057qib7 7718 24 sign sign NN cord-005453-4057qib7 7718 25 of of IN cord-005453-4057qib7 7718 26 graft graft NN cord-005453-4057qib7 7718 27 dysfunction dysfunction NN cord-005453-4057qib7 7718 28 . . . cord-005453-4057qib7 7719 1 Acute acute JJ cord-005453-4057qib7 7719 2 GVHD GVHD NNP cord-005453-4057qib7 7719 3 is be VBZ cord-005453-4057qib7 7719 4 verified verify VBN cord-005453-4057qib7 7719 5 in in IN cord-005453-4057qib7 7719 6 1 1 CD cord-005453-4057qib7 7719 7 of of IN cord-005453-4057qib7 7719 8 5 5 CD cord-005453-4057qib7 7719 9 cases case NNS cord-005453-4057qib7 7719 10 and and CC cord-005453-4057qib7 7719 11 was be VBD cord-005453-4057qib7 7719 12 limited limit VBN cord-005453-4057qib7 7719 13 to to TO cord-005453-4057qib7 7719 14 skin skin VB cord-005453-4057qib7 7719 15 grade grade NN cord-005453-4057qib7 7719 16 2 2 CD cord-005453-4057qib7 7719 17 . . . cord-005453-4057qib7 7720 1 All all DT cord-005453-4057qib7 7720 2 patients patient NNS cord-005453-4057qib7 7720 3 are be VBP cord-005453-4057qib7 7720 4 alive alive JJ cord-005453-4057qib7 7720 5 for for IN cord-005453-4057qib7 7720 6 periods period NNS cord-005453-4057qib7 7720 7 from from IN cord-005453-4057qib7 7720 8 3 3 CD cord-005453-4057qib7 7720 9 to to TO cord-005453-4057qib7 7720 10 8 8 CD cord-005453-4057qib7 7720 11 months month NNS cord-005453-4057qib7 7720 12 post post NN cord-005453-4057qib7 7720 13 - - JJ cord-005453-4057qib7 7720 14 HSCT HSCT NNP cord-005453-4057qib7 7720 15 with with IN cord-005453-4057qib7 7720 16 good good JJ cord-005453-4057qib7 7720 17 graft graft NN cord-005453-4057qib7 7720 18 function function NN cord-005453-4057qib7 7720 19 without without IN cord-005453-4057qib7 7720 20 severe severe JJ cord-005453-4057qib7 7720 21 clinical clinical JJ cord-005453-4057qib7 7720 22 problems problem NNS cord-005453-4057qib7 7720 23 . . . cord-005453-4057qib7 7721 1 Conclusions conclusion NNS cord-005453-4057qib7 7721 2 : : : cord-005453-4057qib7 7722 1 We -PRON- PRP cord-005453-4057qib7 7722 2 presented present VBD cord-005453-4057qib7 7722 3 first first JJ cord-005453-4057qib7 7722 4 experience experience NN cord-005453-4057qib7 7722 5 of of IN cord-005453-4057qib7 7722 6 G G NNP cord-005453-4057qib7 7722 7 - - HYPH cord-005453-4057qib7 7722 8 CSF CSF NNP cord-005453-4057qib7 7722 9 and and CC cord-005453-4057qib7 7722 10 plerixafor plerixafor NN cord-005453-4057qib7 7722 11 addition addition NN cord-005453-4057qib7 7722 12 to to IN cord-005453-4057qib7 7722 13 conditioning conditioning NN cord-005453-4057qib7 7722 14 regimen regimen NN cord-005453-4057qib7 7722 15 before before IN cord-005453-4057qib7 7722 16 HSCT HSCT NNP cord-005453-4057qib7 7722 17 with with IN cord-005453-4057qib7 7722 18 TCRαβ+/CD19 tcrαβ+/cd19 NN cord-005453-4057qib7 7722 19 + + CC cord-005453-4057qib7 7722 20 graft graft NN cord-005453-4057qib7 7722 21 depletion depletion NN cord-005453-4057qib7 7722 22 in in IN cord-005453-4057qib7 7722 23 CGD CGD NNP cord-005453-4057qib7 7722 24 patients patient NNS cord-005453-4057qib7 7722 25 . . . cord-005453-4057qib7 7723 1 We -PRON- PRP cord-005453-4057qib7 7723 2 suppose suppose VBP cord-005453-4057qib7 7723 3 , , , cord-005453-4057qib7 7723 4 the the DT cord-005453-4057qib7 7723 5 preliminary preliminary JJ cord-005453-4057qib7 7723 6 results result NNS cord-005453-4057qib7 7723 7 are be VBP cord-005453-4057qib7 7723 8 encouraging encouraging JJ cord-005453-4057qib7 7723 9 , , , cord-005453-4057qib7 7723 10 as as IN cord-005453-4057qib7 7723 11 the the DT cord-005453-4057qib7 7723 12 frequency frequency NN cord-005453-4057qib7 7723 13 of of IN cord-005453-4057qib7 7723 14 primary primary JJ cord-005453-4057qib7 7723 15 and and CC cord-005453-4057qib7 7723 16 secondary secondary JJ cord-005453-4057qib7 7723 17 graft graft NN cord-005453-4057qib7 7723 18 dysfunction dysfunction NN cord-005453-4057qib7 7723 19 in in IN cord-005453-4057qib7 7723 20 patients patient NNS cord-005453-4057qib7 7723 21 from from IN cord-005453-4057qib7 7723 22 this this DT cord-005453-4057qib7 7723 23 group group NN cord-005453-4057qib7 7723 24 is be VBZ cord-005453-4057qib7 7723 25 not not RB cord-005453-4057qib7 7723 26 observed observe VBN cord-005453-4057qib7 7723 27 today today NN cord-005453-4057qib7 7723 28 , , , cord-005453-4057qib7 7723 29 there there EX cord-005453-4057qib7 7723 30 are be VBP cord-005453-4057qib7 7723 31 no no DT cord-005453-4057qib7 7723 32 significant significant JJ cord-005453-4057qib7 7723 33 toxic toxic JJ cord-005453-4057qib7 7723 34 complications complication NNS cord-005453-4057qib7 7723 35 , , , cord-005453-4057qib7 7723 36 as as RB cord-005453-4057qib7 7723 37 well well RB cord-005453-4057qib7 7723 38 as as IN cord-005453-4057qib7 7723 39 clinically clinically RB cord-005453-4057qib7 7723 40 severe severe JJ cord-005453-4057qib7 7723 41 manifestations manifestation NNS cord-005453-4057qib7 7723 42 of of IN cord-005453-4057qib7 7723 43 GVHD GVHD NNP cord-005453-4057qib7 7723 44 . . . cord-005453-4057qib7 7724 1 Currently currently RB cord-005453-4057qib7 7724 2 , , , cord-005453-4057qib7 7724 3 the the DT cord-005453-4057qib7 7724 4 recruitment recruitment NN cord-005453-4057qib7 7724 5 of of IN cord-005453-4057qib7 7724 6 patients patient NNS cord-005453-4057qib7 7724 7 is be VBZ cord-005453-4057qib7 7724 8 continuing continue VBG cord-005453-4057qib7 7724 9 , , , cord-005453-4057qib7 7724 10 and and CC cord-005453-4057qib7 7724 11 estimation estimation NN cord-005453-4057qib7 7724 12 of of IN cord-005453-4057qib7 7724 13 the the DT cord-005453-4057qib7 7724 14 rates rate NNS cord-005453-4057qib7 7724 15 of of IN cord-005453-4057qib7 7724 16 immune immune JJ cord-005453-4057qib7 7724 17 reconstitution reconstitution NN cord-005453-4057qib7 7724 18 and and CC cord-005453-4057qib7 7724 19 a a DT cord-005453-4057qib7 7724 20 more more JJR cord-005453-4057qib7 7724 21 detail detail NN cord-005453-4057qib7 7724 22 analyses analysis NNS cord-005453-4057qib7 7724 23 will will MD cord-005453-4057qib7 7724 24 be be VB cord-005453-4057qib7 7724 25 evaluated evaluate VBN cord-005453-4057qib7 7724 26 later later RB cord-005453-4057qib7 7724 27 . . . cord-005453-4057qib7 7725 1 Background background NN cord-005453-4057qib7 7725 2 : : : cord-005453-4057qib7 7726 1 Introduction introduction NN cord-005453-4057qib7 7726 2 -It -It : cord-005453-4057qib7 7726 3 is be VBZ cord-005453-4057qib7 7726 4 believed believe VBN cord-005453-4057qib7 7726 5 that that IN cord-005453-4057qib7 7726 6 ABOincompatibility aboincompatibility NN cord-005453-4057qib7 7726 7 is be VBZ cord-005453-4057qib7 7726 8 of of IN cord-005453-4057qib7 7726 9 minor minor JJ cord-005453-4057qib7 7726 10 importance importance NN cord-005453-4057qib7 7726 11 in in IN cord-005453-4057qib7 7726 12 allogeneic allogeneic NN cord-005453-4057qib7 7726 13 stem stem NN cord-005453-4057qib7 7726 14 cell cell NN cord-005453-4057qib7 7726 15 transplantation transplantation NN cord-005453-4057qib7 7726 16 ( ( -LRB- cord-005453-4057qib7 7726 17 allo allo FW cord-005453-4057qib7 7726 18 - - HYPH cord-005453-4057qib7 7726 19 SCT SCT NNP cord-005453-4057qib7 7726 20 ) ) -RRB- cord-005453-4057qib7 7726 21 and and CC cord-005453-4057qib7 7726 22 that that IN cord-005453-4057qib7 7726 23 the the DT cord-005453-4057qib7 7726 24 clinical clinical JJ cord-005453-4057qib7 7726 25 outcome outcome NN cord-005453-4057qib7 7726 26 is be VBZ cord-005453-4057qib7 7726 27 equivalent equivalent JJ cord-005453-4057qib7 7726 28 to to IN cord-005453-4057qib7 7726 29 ABO ABO NNP cord-005453-4057qib7 7726 30 - - HYPH cord-005453-4057qib7 7726 31 compatible compatible JJ cord-005453-4057qib7 7726 32 SCT SCT NNP cord-005453-4057qib7 7726 33 . . . cord-005453-4057qib7 7727 1 Therefore therefore RB cord-005453-4057qib7 7727 2 , , , cord-005453-4057qib7 7727 3 we -PRON- PRP cord-005453-4057qib7 7727 4 performed perform VBD cord-005453-4057qib7 7727 5 a a DT cord-005453-4057qib7 7727 6 single single JJ cord-005453-4057qib7 7727 7 center center NN cord-005453-4057qib7 7727 8 retrospective retrospective JJ cord-005453-4057qib7 7727 9 study study NN cord-005453-4057qib7 7727 10 to to TO cord-005453-4057qib7 7727 11 characterize characterize VB cord-005453-4057qib7 7727 12 the the DT cord-005453-4057qib7 7727 13 impact impact NN cord-005453-4057qib7 7727 14 of of IN cord-005453-4057qib7 7727 15 ABO ABO NNP cord-005453-4057qib7 7727 16 - - HYPH cord-005453-4057qib7 7727 17 incompatibility incompatibility NN cord-005453-4057qib7 7727 18 on on IN cord-005453-4057qib7 7727 19 the the DT cord-005453-4057qib7 7727 20 outcome outcome NN cord-005453-4057qib7 7727 21 of of IN cord-005453-4057qib7 7727 22 haploidentical haploidentical JJ cord-005453-4057qib7 7727 23 stem stem NN cord-005453-4057qib7 7727 24 cell cell NN cord-005453-4057qib7 7727 25 transplantation transplantation NN cord-005453-4057qib7 7727 26 ( ( -LRB- cord-005453-4057qib7 7727 27 Haplo Haplo NNP cord-005453-4057qib7 7727 28 - - HYPH cord-005453-4057qib7 7727 29 SCT SCT NNP cord-005453-4057qib7 7727 30 ) ) -RRB- cord-005453-4057qib7 7727 31 . . . cord-005453-4057qib7 7728 1 Methods method NNS cord-005453-4057qib7 7728 2 : : : cord-005453-4057qib7 7729 1 This this DT cord-005453-4057qib7 7729 2 analysis analysis NN cord-005453-4057qib7 7729 3 included include VBD cord-005453-4057qib7 7729 4 27 27 CD cord-005453-4057qib7 7729 5 consecutive consecutive JJ cord-005453-4057qib7 7729 6 patients patient NNS cord-005453-4057qib7 7729 7 who who WP cord-005453-4057qib7 7729 8 underwent undergo VBD cord-005453-4057qib7 7729 9 haplo haplo NNP cord-005453-4057qib7 7729 10 - - HYPH cord-005453-4057qib7 7729 11 SCT SCT NNP cord-005453-4057qib7 7729 12 for for IN cord-005453-4057qib7 7729 13 various various JJ cord-005453-4057qib7 7729 14 hematological hematological JJ cord-005453-4057qib7 7729 15 malignancies malignancy NNS cord-005453-4057qib7 7729 16 at at IN cord-005453-4057qib7 7729 17 our -PRON- PRP$ cord-005453-4057qib7 7729 18 center center NN cord-005453-4057qib7 7729 19 between between IN cord-005453-4057qib7 7729 20 October October NNP cord-005453-4057qib7 7729 21 2010 2010 CD cord-005453-4057qib7 7729 22 and and CC cord-005453-4057qib7 7729 23 May May NNP cord-005453-4057qib7 7729 24 2018 2018 CD cord-005453-4057qib7 7729 25 . . . cord-005453-4057qib7 7730 1 We -PRON- PRP cord-005453-4057qib7 7730 2 used use VBD cord-005453-4057qib7 7730 3 our -PRON- PRP$ cord-005453-4057qib7 7730 4 institutional institutional JJ cord-005453-4057qib7 7730 5 database database NN cord-005453-4057qib7 7730 6 to to TO cord-005453-4057qib7 7730 7 evaluate evaluate VB cord-005453-4057qib7 7730 8 details detail NNS cord-005453-4057qib7 7730 9 and and CC cord-005453-4057qib7 7730 10 characteristics characteristic NNS cord-005453-4057qib7 7730 11 of of IN cord-005453-4057qib7 7730 12 patients patient NNS cord-005453-4057qib7 7730 13 and and CC cord-005453-4057qib7 7730 14 transplant transplant NN cord-005453-4057qib7 7730 15 outcomes outcome NNS cord-005453-4057qib7 7730 16 . . . cord-005453-4057qib7 7731 1 Results result NNS cord-005453-4057qib7 7731 2 : : : cord-005453-4057qib7 7732 1 Demographic demographic JJ cord-005453-4057qib7 7732 2 features feature NNS cord-005453-4057qib7 7732 3 of of IN cord-005453-4057qib7 7732 4 the the DT cord-005453-4057qib7 7732 5 patients patient NNS cord-005453-4057qib7 7732 6 and and CC cord-005453-4057qib7 7732 7 donors donor NNS cord-005453-4057qib7 7732 8 have have VBP cord-005453-4057qib7 7732 9 been be VBN cord-005453-4057qib7 7732 10 summarized summarize VBN cord-005453-4057qib7 7732 11 in in IN cord-005453-4057qib7 7732 12 Table Table NNP cord-005453-4057qib7 7732 13 1 1 CD cord-005453-4057qib7 7732 14 . . . cord-005453-4057qib7 7733 1 All all DT cord-005453-4057qib7 7733 2 of of IN cord-005453-4057qib7 7733 3 the the DT cord-005453-4057qib7 7733 4 patients patient NNS cord-005453-4057qib7 7733 5 had have VBD cord-005453-4057qib7 7733 6 advanced advanced JJ cord-005453-4057qib7 7733 7 hematological hematological JJ cord-005453-4057qib7 7733 8 disease disease NN cord-005453-4057qib7 7733 9 with with IN cord-005453-4057qib7 7733 10 a a DT cord-005453-4057qib7 7733 11 high high JJ cord-005453-4057qib7 7733 12 risk risk NN cord-005453-4057qib7 7733 13 of of IN cord-005453-4057qib7 7733 14 relapse relapse NN cord-005453-4057qib7 7733 15 ( ( -LRB- cord-005453-4057qib7 7733 16 22 22 CD cord-005453-4057qib7 7733 17 patients patient NNS cord-005453-4057qib7 7733 18 with with IN cord-005453-4057qib7 7733 19 acute acute JJ cord-005453-4057qib7 7733 20 leukemia leukemia NN cord-005453-4057qib7 7733 21 ) ) -RRB- cord-005453-4057qib7 7733 22 . . . cord-005453-4057qib7 7734 1 Out out IN cord-005453-4057qib7 7734 2 of of IN cord-005453-4057qib7 7734 3 24 24 CD cord-005453-4057qib7 7734 4 patients patient NNS cord-005453-4057qib7 7734 5 , , , cord-005453-4057qib7 7734 6 early early JJ cord-005453-4057qib7 7734 7 transplant transplant NN cord-005453-4057qib7 7734 8 - - HYPH cord-005453-4057qib7 7734 9 related relate VBN cord-005453-4057qib7 7734 10 mortality mortality NN cord-005453-4057qib7 7734 11 was be VBD cord-005453-4057qib7 7734 12 seen see VBN cord-005453-4057qib7 7734 13 in in IN cord-005453-4057qib7 7734 14 this this DT cord-005453-4057qib7 7734 15 cohort cohort NN cord-005453-4057qib7 7734 16 of of IN cord-005453-4057qib7 7734 17 5 5 CD cord-005453-4057qib7 7734 18 patients patient NNS cord-005453-4057qib7 7734 19 . . . cord-005453-4057qib7 7735 1 The the DT cord-005453-4057qib7 7735 2 remaining remain VBG cord-005453-4057qib7 7735 3 19 19 CD cord-005453-4057qib7 7735 4 patients patient NNS cord-005453-4057qib7 7735 5 were be VBD cord-005453-4057qib7 7735 6 followed follow VBN cord-005453-4057qib7 7735 7 in in IN cord-005453-4057qib7 7735 8 1 1 CD cord-005453-4057qib7 7735 9 and and CC cord-005453-4057qib7 7735 10 42 42 CD cord-005453-4057qib7 7735 11 months month NNS cord-005453-4057qib7 7735 12 . . . cord-005453-4057qib7 7736 1 Donor donor NN cord-005453-4057qib7 7736 2 type type NN cord-005453-4057qib7 7736 3 ABO ABO NNP cord-005453-4057qib7 7736 4 group group NN cord-005453-4057qib7 7736 5 switch switch NN cord-005453-4057qib7 7736 6 was be VBD cord-005453-4057qib7 7736 7 observed observe VBN cord-005453-4057qib7 7736 8 in in IN cord-005453-4057qib7 7736 9 a a DT cord-005453-4057qib7 7736 10 median median NN cord-005453-4057qib7 7736 11 of of IN cord-005453-4057qib7 7736 12 45 45 CD cord-005453-4057qib7 7736 13 days day NNS cord-005453-4057qib7 7736 14 ( ( -LRB- cord-005453-4057qib7 7736 15 30 30 CD cord-005453-4057qib7 7736 16 - - SYM cord-005453-4057qib7 7736 17 60 60 CD cord-005453-4057qib7 7736 18 days day NNS cord-005453-4057qib7 7736 19 ) ) -RRB- cord-005453-4057qib7 7736 20 after after IN cord-005453-4057qib7 7736 21 transplant transplant NN cord-005453-4057qib7 7736 22 . . . cord-005453-4057qib7 7737 1 We -PRON- PRP cord-005453-4057qib7 7737 2 were be VBD cord-005453-4057qib7 7737 3 not not RB cord-005453-4057qib7 7737 4 able able JJ cord-005453-4057qib7 7737 5 to to TO cord-005453-4057qib7 7737 6 show show VB cord-005453-4057qib7 7737 7 any any DT cord-005453-4057qib7 7737 8 statistical statistical JJ cord-005453-4057qib7 7737 9 difference difference NN cord-005453-4057qib7 7737 10 in in IN cord-005453-4057qib7 7737 11 terms term NNS cord-005453-4057qib7 7737 12 of of IN cord-005453-4057qib7 7737 13 blood blood NN cord-005453-4057qib7 7737 14 group group NN cord-005453-4057qib7 7737 15 switch switch NN cord-005453-4057qib7 7737 16 between between IN cord-005453-4057qib7 7737 17 minor minor JJ cord-005453-4057qib7 7737 18 and and CC cord-005453-4057qib7 7737 19 major major JJ cord-005453-4057qib7 7737 20 ABO ABO NNP cord-005453-4057qib7 7737 21 incompatible incompatible JJ cord-005453-4057qib7 7737 22 transplant transplant NN cord-005453-4057qib7 7737 23 . . . cord-005453-4057qib7 7738 1 The the DT cord-005453-4057qib7 7738 2 median median JJ cord-005453-4057qib7 7738 3 red red JJ cord-005453-4057qib7 7738 4 blood blood NN cord-005453-4057qib7 7738 5 cell cell NN cord-005453-4057qib7 7738 6 ( ( -LRB- cord-005453-4057qib7 7738 7 RBC RBC NNP cord-005453-4057qib7 7738 8 ) ) -RRB- cord-005453-4057qib7 7738 9 transfusions transfusion NNS cord-005453-4057qib7 7738 10 in in IN cord-005453-4057qib7 7738 11 the the DT cord-005453-4057qib7 7738 12 first first JJ cord-005453-4057qib7 7738 13 30 30 CD cord-005453-4057qib7 7738 14 days day NNS cord-005453-4057qib7 7738 15 for for IN cord-005453-4057qib7 7738 16 the the DT cord-005453-4057qib7 7738 17 ABO ABO NNP cord-005453-4057qib7 7738 18 compatible compatible JJ cord-005453-4057qib7 7738 19 and and CC cord-005453-4057qib7 7738 20 incompatible incompatible JJ cord-005453-4057qib7 7738 21 transplants transplant NNS cord-005453-4057qib7 7738 22 were be VBD cord-005453-4057qib7 7738 23 median median JJ cord-005453-4057qib7 7738 24 4 4 CD cord-005453-4057qib7 7738 25 units unit NNS cord-005453-4057qib7 7738 26 ( ( -LRB- cord-005453-4057qib7 7738 27 range range NN cord-005453-4057qib7 7738 28 , , , cord-005453-4057qib7 7738 29 0 0 CD cord-005453-4057qib7 7738 30 - - SYM cord-005453-4057qib7 7738 31 11 11 CD cord-005453-4057qib7 7738 32 ) ) -RRB- cord-005453-4057qib7 7738 33 and and CC cord-005453-4057qib7 7738 34 median median JJ cord-005453-4057qib7 7738 35 4 4 CD cord-005453-4057qib7 7738 36 units unit NNS cord-005453-4057qib7 7738 37 ( ( -LRB- cord-005453-4057qib7 7738 38 range range VBP cord-005453-4057qib7 7738 39 , , , cord-005453-4057qib7 7738 40 3 3 CD cord-005453-4057qib7 7738 41 - - SYM cord-005453-4057qib7 7738 42 12 12 CD cord-005453-4057qib7 7738 43 ) ) -RRB- cord-005453-4057qib7 7738 44 ( ( -LRB- cord-005453-4057qib7 7738 45 p=0.6 p=0.6 NN cord-005453-4057qib7 7738 46 ) ) -RRB- cord-005453-4057qib7 7738 47 . . . cord-005453-4057qib7 7739 1 No no DT cord-005453-4057qib7 7739 2 statistical statistical JJ cord-005453-4057qib7 7739 3 difference difference NN cord-005453-4057qib7 7739 4 was be VBD cord-005453-4057qib7 7739 5 also also RB cord-005453-4057qib7 7739 6 encountered encounter VBN cord-005453-4057qib7 7739 7 for for IN cord-005453-4057qib7 7739 8 the the DT cord-005453-4057qib7 7739 9 RBC RBC NNP cord-005453-4057qib7 7739 10 transfusion transfusion NN cord-005453-4057qib7 7739 11 need need NN cord-005453-4057qib7 7739 12 for for IN cord-005453-4057qib7 7739 13 stem stem NN cord-005453-4057qib7 7739 14 cell cell NN cord-005453-4057qib7 7739 15 source source NN cord-005453-4057qib7 7739 16 , , , cord-005453-4057qib7 7739 17 peripheral peripheral JJ cord-005453-4057qib7 7739 18 blood blood NN cord-005453-4057qib7 7739 19 vs vs IN cord-005453-4057qib7 7739 20 bone bone NN cord-005453-4057qib7 7739 21 marrow marrow NN cord-005453-4057qib7 7739 22 . . . cord-005453-4057qib7 7740 1 A a DT cord-005453-4057qib7 7740 2 total total NN cord-005453-4057qib7 7740 3 of of IN cord-005453-4057qib7 7740 4 15 15 CD cord-005453-4057qib7 7740 5 patients patient NNS cord-005453-4057qib7 7740 6 were be VBD cord-005453-4057qib7 7740 7 followed follow VBN cord-005453-4057qib7 7740 8 up up RP cord-005453-4057qib7 7740 9 for for IN cord-005453-4057qib7 7740 10 reticulocyte reticulocyte NNP cord-005453-4057qib7 7740 11 engraftment engraftment NNP cord-005453-4057qib7 7740 12 . . . cord-005453-4057qib7 7741 1 The the DT cord-005453-4057qib7 7741 2 median median JJ cord-005453-4057qib7 7741 3 time time NN cord-005453-4057qib7 7741 4 for for IN cord-005453-4057qib7 7741 5 reticulocyte reticulocyte NNP cord-005453-4057qib7 7741 6 engraftment engraftment NNP cord-005453-4057qib7 7741 7 was be VBD cord-005453-4057qib7 7741 8 19 19 CD cord-005453-4057qib7 7741 9 days day NNS cord-005453-4057qib7 7741 10 ( ( -LRB- cord-005453-4057qib7 7741 11 range range NN cord-005453-4057qib7 7741 12 , , , cord-005453-4057qib7 7741 13 15 15 CD cord-005453-4057qib7 7741 14 - - SYM cord-005453-4057qib7 7741 15 60 60 CD cord-005453-4057qib7 7741 16 ) ) -RRB- cord-005453-4057qib7 7741 17 for for IN cord-005453-4057qib7 7741 18 all all DT cord-005453-4057qib7 7741 19 patients patient NNS cord-005453-4057qib7 7741 20 . . . cord-005453-4057qib7 7742 1 Reticulocyte Reticulocyte NNP cord-005453-4057qib7 7742 2 engraftment engraftment NNP cord-005453-4057qib7 7742 3 was be VBD cord-005453-4057qib7 7742 4 tended tend VBN cord-005453-4057qib7 7742 5 to to TO cord-005453-4057qib7 7742 6 be be VB cord-005453-4057qib7 7742 7 faster fast JJR cord-005453-4057qib7 7742 8 in in IN cord-005453-4057qib7 7742 9 minor minor JJ cord-005453-4057qib7 7742 10 ABO abo NN cord-005453-4057qib7 7742 11 - - HYPH cord-005453-4057qib7 7742 12 mismatched mismatch VBN cord-005453-4057qib7 7742 13 group group NN cord-005453-4057qib7 7742 14 ( ( -LRB- cord-005453-4057qib7 7742 15 p=0.05 p=0.05 NNP cord-005453-4057qib7 7742 16 ) ) -RRB- cord-005453-4057qib7 7742 17 than than IN cord-005453-4057qib7 7742 18 major major JJ cord-005453-4057qib7 7742 19 or or CC cord-005453-4057qib7 7742 20 ABO ABO NNP cord-005453-4057qib7 7742 21 - - HYPH cord-005453-4057qib7 7742 22 compatible compatible JJ cord-005453-4057qib7 7742 23 ones one NNS cord-005453-4057qib7 7742 24 . . . cord-005453-4057qib7 7743 1 Nineteen nineteen CD cord-005453-4057qib7 7743 2 patients patient NNS cord-005453-4057qib7 7743 3 achieved achieve VBD cord-005453-4057qib7 7743 4 independence independence NN cord-005453-4057qib7 7743 5 from from IN cord-005453-4057qib7 7743 6 RBC RBC NNP cord-005453-4057qib7 7743 7 support support NN cord-005453-4057qib7 7743 8 after after IN cord-005453-4057qib7 7743 9 a a DT cord-005453-4057qib7 7743 10 median median JJ cord-005453-4057qib7 7743 11 time time NN cord-005453-4057qib7 7743 12 of of IN cord-005453-4057qib7 7743 13 44 44 CD cord-005453-4057qib7 7743 14 days day NNS cord-005453-4057qib7 7743 15 ( ( -LRB- cord-005453-4057qib7 7743 16 range range NN cord-005453-4057qib7 7743 17 , , , cord-005453-4057qib7 7743 18 11 11 CD cord-005453-4057qib7 7743 19 - - SYM cord-005453-4057qib7 7743 20 61 61 CD cord-005453-4057qib7 7743 21 days day NNS cord-005453-4057qib7 7743 22 ) ) -RRB- cord-005453-4057qib7 7743 23 in in IN cord-005453-4057qib7 7743 24 ABOcompatible abocompatible JJ cord-005453-4057qib7 7743 25 patients patient NNS cord-005453-4057qib7 7743 26 , , , cord-005453-4057qib7 7743 27 25 25 CD cord-005453-4057qib7 7743 28 days day NNS cord-005453-4057qib7 7743 29 ( ( -LRB- cord-005453-4057qib7 7743 30 range range NN cord-005453-4057qib7 7743 31 , , , cord-005453-4057qib7 7743 32 7 7 CD cord-005453-4057qib7 7743 33 - - SYM cord-005453-4057qib7 7743 34 52 52 CD cord-005453-4057qib7 7743 35 days day NNS cord-005453-4057qib7 7743 36 ) ) -RRB- cord-005453-4057qib7 7743 37 in in IN cord-005453-4057qib7 7743 38 minor minor JJ cord-005453-4057qib7 7743 39 ABO ABO NNP cord-005453-4057qib7 7743 40 - - HYPH cord-005453-4057qib7 7743 41 incompatibilityand incompatibilityand NNP cord-005453-4057qib7 7743 42 34 34 CD cord-005453-4057qib7 7743 43 days day NNS cord-005453-4057qib7 7743 44 ( ( -LRB- cord-005453-4057qib7 7743 45 range range NN cord-005453-4057qib7 7743 46 , , , cord-005453-4057qib7 7743 47 20 20 CD cord-005453-4057qib7 7743 48 - - SYM cord-005453-4057qib7 7743 49 57 57 CD cord-005453-4057qib7 7743 50 days day NNS cord-005453-4057qib7 7743 51 ) ) -RRB- cord-005453-4057qib7 7743 52 in in IN cord-005453-4057qib7 7743 53 major major JJ cord-005453-4057qib7 7743 54 ABO ABO NNP cord-005453-4057qib7 7743 55 - - HYPH cord-005453-4057qib7 7743 56 incompatibilitygroup incompatibilitygroup NNP cord-005453-4057qib7 7743 57 , , , cord-005453-4057qib7 7743 58 respectively respectively RB cord-005453-4057qib7 7743 59 ( ( -LRB- cord-005453-4057qib7 7743 60 p>0.5 p>0.5 NNP cord-005453-4057qib7 7743 61 ) ) -RRB- cord-005453-4057qib7 7743 62 . . . cord-005453-4057qib7 7744 1 The the DT cord-005453-4057qib7 7744 2 engraftman engraftman NN cord-005453-4057qib7 7744 3 kinetics kinetic NNS cord-005453-4057qib7 7744 4 due due JJ cord-005453-4057qib7 7744 5 to to IN cord-005453-4057qib7 7744 6 major major JJ cord-005453-4057qib7 7744 7 and and CC cord-005453-4057qib7 7744 8 minor minor JJ cord-005453-4057qib7 7744 9 ABOincompatibilitytransplants aboincompatibilitytransplant NNS cord-005453-4057qib7 7744 10 were be VBD cord-005453-4057qib7 7744 11 presented present VBN cord-005453-4057qib7 7744 12 in in IN cord-005453-4057qib7 7744 13 Table- Table- NNP cord-005453-4057qib7 7744 14 2 2 CD cord-005453-4057qib7 7744 15 . . . cord-005453-4057qib7 7745 1 Pure pure JJ cord-005453-4057qib7 7745 2 red red JJ cord-005453-4057qib7 7745 3 cell cell NN cord-005453-4057qib7 7745 4 aplasia aplasia NNP cord-005453-4057qib7 7745 5 was be VBD cord-005453-4057qib7 7745 6 not not RB cord-005453-4057qib7 7745 7 developed develop VBN cord-005453-4057qib7 7745 8 in in IN cord-005453-4057qib7 7745 9 our -PRON- PRP$ cord-005453-4057qib7 7745 10 cohort cohort NN cord-005453-4057qib7 7745 11 . . . cord-005453-4057qib7 7746 1 Conclusions conclusion NNS cord-005453-4057qib7 7746 2 : : : cord-005453-4057qib7 7747 1 The the DT cord-005453-4057qib7 7747 2 present present JJ cord-005453-4057qib7 7747 3 single single JJ cord-005453-4057qib7 7747 4 center center NN cord-005453-4057qib7 7747 5 study study NN cord-005453-4057qib7 7747 6 provides provide VBZ cord-005453-4057qib7 7747 7 new new JJ cord-005453-4057qib7 7747 8 evidence evidence NN cord-005453-4057qib7 7747 9 for for IN cord-005453-4057qib7 7747 10 the the DT cord-005453-4057qib7 7747 11 importance importance NN cord-005453-4057qib7 7747 12 of of IN cord-005453-4057qib7 7747 13 the the DT cord-005453-4057qib7 7747 14 ABO ABO NNP cord-005453-4057qib7 7747 15 system system NN cord-005453-4057qib7 7747 16 for for IN cord-005453-4057qib7 7747 17 erythrocyte erythrocyte NN cord-005453-4057qib7 7747 18 recovery recovery NN cord-005453-4057qib7 7747 19 in in IN cord-005453-4057qib7 7747 20 haploidentic haploidentic JJ cord-005453-4057qib7 7747 21 stem stem NN cord-005453-4057qib7 7747 22 cell cell NN cord-005453-4057qib7 7747 23 transplantation transplantation NN cord-005453-4057qib7 7747 24 . . . cord-005453-4057qib7 7748 1 It -PRON- PRP cord-005453-4057qib7 7748 2 's be VBZ cord-005453-4057qib7 7748 3 important important JJ cord-005453-4057qib7 7748 4 to to TO cord-005453-4057qib7 7748 5 note note VB cord-005453-4057qib7 7748 6 that that IN cord-005453-4057qib7 7748 7 , , , cord-005453-4057qib7 7748 8 randomize randomize VB cord-005453-4057qib7 7748 9 prospective prospective JJ cord-005453-4057qib7 7748 10 and and CC cord-005453-4057qib7 7748 11 larger large JJR cord-005453-4057qib7 7748 12 studies study NNS cord-005453-4057qib7 7748 13 are be VBP cord-005453-4057qib7 7748 14 warranted warrant VBN cord-005453-4057qib7 7748 15 . . . cord-005453-4057qib7 7749 1 Disclosure disclosure NN cord-005453-4057qib7 7749 2 : : : cord-005453-4057qib7 7749 3 Nothing nothing NN cord-005453-4057qib7 7749 4 to to TO cord-005453-4057qib7 7749 5 declare declare VB cord-005453-4057qib7 7749 6 Low Low NNP cord-005453-4057qib7 7749 7 dose dose NN cord-005453-4057qib7 7749 8 of of IN cord-005453-4057qib7 7749 9 anti anti JJ cord-005453-4057qib7 7749 10 - - JJ cord-005453-4057qib7 7749 11 T t JJ cord-005453-4057qib7 7749 12 lymphocyte lymphocyte NN cord-005453-4057qib7 7749 13 globulin globulin NN cord-005453-4057qib7 7749 14 protects protect VBZ cord-005453-4057qib7 7749 15 against against IN cord-005453-4057qib7 7749 16 severe severe JJ cord-005453-4057qib7 7749 17 forms form NNS cord-005453-4057qib7 7749 18 of of IN cord-005453-4057qib7 7749 19 graft graft NN cord-005453-4057qib7 7749 20 versus versus IN cord-005453-4057qib7 7749 21 host host NN cord-005453-4057qib7 7749 22 disease disease NN cord-005453-4057qib7 7749 23 in in IN cord-005453-4057qib7 7749 24 patients patient NNS cord-005453-4057qib7 7749 25 undergoing undergo VBG cord-005453-4057qib7 7749 26 allogenic allogenic JJ cord-005453-4057qib7 7749 27 stem stem NN cord-005453-4057qib7 7749 28 cell cell NN cord-005453-4057qib7 7749 29 transplantation transplantation NN cord-005453-4057qib7 7749 30 Background background NN cord-005453-4057qib7 7749 31 : : : cord-005453-4057qib7 7750 1 Graft graft NN cord-005453-4057qib7 7750 2 versus versus IN cord-005453-4057qib7 7750 3 host host NN cord-005453-4057qib7 7750 4 disease disease NN cord-005453-4057qib7 7750 5 ( ( -LRB- cord-005453-4057qib7 7750 6 GvHD GvHD NNP cord-005453-4057qib7 7750 7 ) ) -RRB- cord-005453-4057qib7 7750 8 is be VBZ cord-005453-4057qib7 7750 9 the the DT cord-005453-4057qib7 7750 10 most most RBS cord-005453-4057qib7 7750 11 important important JJ cord-005453-4057qib7 7750 12 complication complication NN cord-005453-4057qib7 7750 13 after after IN cord-005453-4057qib7 7750 14 allogeneic allogeneic NN cord-005453-4057qib7 7750 15 stem stem NN cord-005453-4057qib7 7750 16 cell cell NN cord-005453-4057qib7 7750 17 transplantation transplantation NN cord-005453-4057qib7 7750 18 ( ( -LRB- cord-005453-4057qib7 7750 19 alloSCT alloSCT NNP cord-005453-4057qib7 7750 20 ) ) -RRB- cord-005453-4057qib7 7750 21 . . . cord-005453-4057qib7 7751 1 Optimal optimal JJ cord-005453-4057qib7 7751 2 dose dose NN cord-005453-4057qib7 7751 3 of of IN cord-005453-4057qib7 7751 4 different different JJ cord-005453-4057qib7 7751 5 anti anti JJ cord-005453-4057qib7 7751 6 - - JJ cord-005453-4057qib7 7751 7 Tlymphocyte tlymphocyte JJ cord-005453-4057qib7 7751 8 globulin globulin NN cord-005453-4057qib7 7751 9 ( ( -LRB- cord-005453-4057qib7 7751 10 ATG ATG NNP cord-005453-4057qib7 7751 11 ) ) -RRB- cord-005453-4057qib7 7751 12 formulations formulation NNS cord-005453-4057qib7 7751 13 in in IN cord-005453-4057qib7 7751 14 this this DT cord-005453-4057qib7 7751 15 setting setting NN cord-005453-4057qib7 7751 16 has have VBZ cord-005453-4057qib7 7751 17 not not RB cord-005453-4057qib7 7751 18 been be VBN cord-005453-4057qib7 7751 19 established establish VBN cord-005453-4057qib7 7751 20 yet yet RB cord-005453-4057qib7 7751 21 . . . cord-005453-4057qib7 7752 1 The the DT cord-005453-4057qib7 7752 2 aim aim NN cord-005453-4057qib7 7752 3 of of IN cord-005453-4057qib7 7752 4 this this DT cord-005453-4057qib7 7752 5 study study NN cord-005453-4057qib7 7752 6 was be VBD cord-005453-4057qib7 7752 7 to to TO cord-005453-4057qib7 7752 8 analyze analyze VB cord-005453-4057qib7 7752 9 the the DT cord-005453-4057qib7 7752 10 impact impact NN cord-005453-4057qib7 7752 11 of of IN cord-005453-4057qib7 7752 12 a a DT cord-005453-4057qib7 7752 13 low low JJ cord-005453-4057qib7 7752 14 dose dose NN cord-005453-4057qib7 7752 15 of of IN cord-005453-4057qib7 7752 16 ATG ATG NNP cord-005453-4057qib7 7752 17 - - HYPH cord-005453-4057qib7 7752 18 Fresenius Fresenius NNP cord-005453-4057qib7 7752 19 ( ( -LRB- cord-005453-4057qib7 7752 20 ATG ATG NNP cord-005453-4057qib7 7752 21 - - HYPH cord-005453-4057qib7 7752 22 F F NNP cord-005453-4057qib7 7752 23 ) ) -RRB- cord-005453-4057qib7 7752 24 in in IN cord-005453-4057qib7 7752 25 alloSCT alloSCT NNP cord-005453-4057qib7 7752 26 outcomes outcome NNS cord-005453-4057qib7 7752 27 . . . cord-005453-4057qib7 7753 1 Methods method NNS cord-005453-4057qib7 7753 2 : : : cord-005453-4057qib7 7753 3 We -PRON- PRP cord-005453-4057qib7 7753 4 analyzed analyze VBD cord-005453-4057qib7 7753 5 57 57 CD cord-005453-4057qib7 7753 6 adult adult NN cord-005453-4057qib7 7753 7 patients patient NNS cord-005453-4057qib7 7753 8 who who WP cord-005453-4057qib7 7753 9 received receive VBD cord-005453-4057qib7 7753 10 an an DT cord-005453-4057qib7 7753 11 alloSCT allosct NN cord-005453-4057qib7 7753 12 for for IN cord-005453-4057qib7 7753 13 hematologic hematologic JJ cord-005453-4057qib7 7753 14 malignancies malignancy NNS cord-005453-4057qib7 7753 15 from from IN cord-005453-4057qib7 7753 16 October October NNP cord-005453-4057qib7 7753 17 2012 2012 CD cord-005453-4057qib7 7753 18 to to IN cord-005453-4057qib7 7753 19 March March NNP cord-005453-4057qib7 7753 20 2018 2018 CD cord-005453-4057qib7 7753 21 . . . cord-005453-4057qib7 7754 1 The the DT cord-005453-4057qib7 7754 2 GvHD GvHD NNP cord-005453-4057qib7 7754 3 prophylaxis prophylaxis NN cord-005453-4057qib7 7754 4 included include VBD cord-005453-4057qib7 7754 5 a a DT cord-005453-4057qib7 7754 6 total total JJ cord-005453-4057qib7 7754 7 dose dose NN cord-005453-4057qib7 7754 8 of of IN cord-005453-4057qib7 7754 9 21 21 CD cord-005453-4057qib7 7754 10 mg mg NNP cord-005453-4057qib7 7754 11 / / SYM cord-005453-4057qib7 7754 12 kg kg NNP cord-005453-4057qib7 7754 13 ( ( -LRB- cord-005453-4057qib7 7754 14 7 7 CD cord-005453-4057qib7 7754 15 mg mg NNP cord-005453-4057qib7 7754 16 / / SYM cord-005453-4057qib7 7754 17 kg kg NNS cord-005453-4057qib7 7754 18 on on IN cord-005453-4057qib7 7754 19 day day NN cord-005453-4057qib7 7754 20 -3 -3 NNP cord-005453-4057qib7 7754 21 , , , cord-005453-4057qib7 7754 22 -2 -2 NNP cord-005453-4057qib7 7754 23 and and CC cord-005453-4057qib7 7754 24 -1 -1 NN cord-005453-4057qib7 7754 25 ) ) -RRB- cord-005453-4057qib7 7754 26 of of IN cord-005453-4057qib7 7754 27 ATG ATG NNP cord-005453-4057qib7 7754 28 - - HYPH cord-005453-4057qib7 7754 29 F F NNP cord-005453-4057qib7 7754 30 for for IN cord-005453-4057qib7 7754 31 patients patient NNS cord-005453-4057qib7 7754 32 who who WP cord-005453-4057qib7 7754 33 received receive VBD cord-005453-4057qib7 7754 34 a a DT cord-005453-4057qib7 7754 35 graft graft NN cord-005453-4057qib7 7754 36 from from IN cord-005453-4057qib7 7754 37 peripheral peripheral JJ cord-005453-4057qib7 7754 38 blood blood NN cord-005453-4057qib7 7754 39 , , , cord-005453-4057qib7 7754 40 an an DT cord-005453-4057qib7 7754 41 unrelated unrelated JJ cord-005453-4057qib7 7754 42 donor donor NN cord-005453-4057qib7 7754 43 ; ; : cord-005453-4057qib7 7754 44 with with IN cord-005453-4057qib7 7754 45 a a DT cord-005453-4057qib7 7754 46 mismatch mismatch NN cord-005453-4057qib7 7754 47 , , , cord-005453-4057qib7 7754 48 and/or and/or CC cord-005453-4057qib7 7754 49 were be VBD cord-005453-4057qib7 7754 50 older old JJR cord-005453-4057qib7 7754 51 than than IN cord-005453-4057qib7 7754 52 55 55 CD cord-005453-4057qib7 7754 53 years year NNS cord-005453-4057qib7 7754 54 ; ; , cord-005453-4057qib7 7754 55 associated associate VBN cord-005453-4057qib7 7754 56 to to IN cord-005453-4057qib7 7754 57 a a DT cord-005453-4057qib7 7754 58 calcineurin calcineurin JJ cord-005453-4057qib7 7754 59 inhibitor inhibitor NN cord-005453-4057qib7 7754 60 and and CC cord-005453-4057qib7 7754 61 mycophenolate mycophenolate NNP cord-005453-4057qib7 7754 62 mofetil mofetil NNP cord-005453-4057qib7 7754 63 / / SYM cord-005453-4057qib7 7754 64 short short JJ cord-005453-4057qib7 7754 65 course course NN cord-005453-4057qib7 7754 66 - - HYPH cord-005453-4057qib7 7754 67 methotrexate methotrexate NN cord-005453-4057qib7 7754 68 . . . cord-005453-4057qib7 7755 1 Statistical statistical JJ cord-005453-4057qib7 7755 2 analysis analysis NN cord-005453-4057qib7 7755 3 was be VBD cord-005453-4057qib7 7755 4 performed perform VBN cord-005453-4057qib7 7755 5 using use VBG cord-005453-4057qib7 7755 6 SPSS SPSS NNP cord-005453-4057qib7 7755 7 v.22 v.22 NNP cord-005453-4057qib7 7755 8 and and CC cord-005453-4057qib7 7755 9 R r NN cord-005453-4057qib7 7755 10 software software NN cord-005453-4057qib7 7755 11 . . . cord-005453-4057qib7 7756 1 Results result NNS cord-005453-4057qib7 7756 2 : : : cord-005453-4057qib7 7757 1 Median median JJ cord-005453-4057qib7 7757 2 age age NN cord-005453-4057qib7 7757 3 was be VBD cord-005453-4057qib7 7757 4 57 57 CD cord-005453-4057qib7 7757 5 years year NNS cord-005453-4057qib7 7757 6 ( ( -LRB- cord-005453-4057qib7 7757 7 18 18 CD cord-005453-4057qib7 7757 8 - - SYM cord-005453-4057qib7 7757 9 70 70 CD cord-005453-4057qib7 7757 10 ) ) -RRB- cord-005453-4057qib7 7757 11 and and CC cord-005453-4057qib7 7757 12 66.7 66.7 CD cord-005453-4057qib7 7757 13 % % NN cord-005453-4057qib7 7757 14 of of IN cord-005453-4057qib7 7757 15 patients patient NNS cord-005453-4057qib7 7757 16 were be VBD cord-005453-4057qib7 7757 17 males male NNS cord-005453-4057qib7 7757 18 . . . cord-005453-4057qib7 7758 1 Seventy seventy CD cord-005453-4057qib7 7758 2 - - HYPH cord-005453-4057qib7 7758 3 four four CD cord-005453-4057qib7 7758 4 percent percent NN cord-005453-4057qib7 7758 5 of of IN cord-005453-4057qib7 7758 6 patients patient NNS cord-005453-4057qib7 7758 7 underwent undergo VBD cord-005453-4057qib7 7758 8 myeloablative myeloablative JJ cord-005453-4057qib7 7758 9 conditioning conditioning NN cord-005453-4057qib7 7758 10 . . . cord-005453-4057qib7 7759 1 The the DT cord-005453-4057qib7 7759 2 stem stem NN cord-005453-4057qib7 7759 3 cell cell NN cord-005453-4057qib7 7759 4 source source NN cord-005453-4057qib7 7759 5 was be VBD cord-005453-4057qib7 7759 6 peripheral peripheral JJ cord-005453-4057qib7 7759 7 blood blood NN cord-005453-4057qib7 7759 8 in in IN cord-005453-4057qib7 7759 9 51 51 CD cord-005453-4057qib7 7759 10 patients patient NNS cord-005453-4057qib7 7759 11 ( ( -LRB- cord-005453-4057qib7 7759 12 89.5 89.5 CD cord-005453-4057qib7 7759 13 % % NN cord-005453-4057qib7 7759 14 ) ) -RRB- cord-005453-4057qib7 7759 15 , , , cord-005453-4057qib7 7759 16 80 80 CD cord-005453-4057qib7 7759 17 % % NN cord-005453-4057qib7 7759 18 were be VBD cord-005453-4057qib7 7759 19 from from IN cord-005453-4057qib7 7759 20 unrelated unrelated JJ cord-005453-4057qib7 7759 21 donors donor NNS cord-005453-4057qib7 7759 22 ( ( -LRB- cord-005453-4057qib7 7759 23 28 28 CD cord-005453-4057qib7 7759 24 % % NN cord-005453-4057qib7 7759 25 mismatched mismatched JJ cord-005453-4057qib7 7759 26 ) ) -RRB- cord-005453-4057qib7 7759 27 . . . cord-005453-4057qib7 7760 1 Seventeen seventeen CD cord-005453-4057qib7 7760 2 ( ( -LRB- cord-005453-4057qib7 7760 3 29.8 29.8 CD cord-005453-4057qib7 7760 4 % % NN cord-005453-4057qib7 7760 5 ) ) -RRB- cord-005453-4057qib7 7761 1 patients patient NNS cord-005453-4057qib7 7761 2 had have VBD cord-005453-4057qib7 7761 3 high high JJ cord-005453-4057qib7 7761 4 risk risk NN cord-005453-4057qib7 7761 5 CMV CMV NNP cord-005453-4057qib7 7761 6 status status NN cord-005453-4057qib7 7761 7 ( ( -LRB- cord-005453-4057qib7 7761 8 D-/R+ D-/R+ NNP cord-005453-4057qib7 7761 9 ) ) -RRB- cord-005453-4057qib7 7761 10 ( ( -LRB- cord-005453-4057qib7 7761 11 see see VB cord-005453-4057qib7 7761 12 image image NN cord-005453-4057qib7 7761 13 1B 1b CD cord-005453-4057qib7 7761 14 ) ) -RRB- cord-005453-4057qib7 7761 15 . . . cord-005453-4057qib7 7762 1 Engraftment Engraftment NNP cord-005453-4057qib7 7762 2 was be VBD cord-005453-4057qib7 7762 3 observed observe VBN cord-005453-4057qib7 7762 4 in in IN cord-005453-4057qib7 7762 5 54 54 CD cord-005453-4057qib7 7762 6 patients patient NNS cord-005453-4057qib7 7762 7 ( ( -LRB- cord-005453-4057qib7 7762 8 94.7 94.7 CD cord-005453-4057qib7 7762 9 % % NN cord-005453-4057qib7 7762 10 ) ) -RRB- cord-005453-4057qib7 7762 11 . . . cord-005453-4057qib7 7763 1 Primary primary JJ cord-005453-4057qib7 7763 2 graft graft NN cord-005453-4057qib7 7763 3 failure failure NN cord-005453-4057qib7 7763 4 occurred occur VBD cord-005453-4057qib7 7763 5 in in IN cord-005453-4057qib7 7763 6 3 3 CD cord-005453-4057qib7 7763 7 patients patient NNS cord-005453-4057qib7 7763 8 ( ( -LRB- cord-005453-4057qib7 7763 9 2 2 CD cord-005453-4057qib7 7763 10 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 7763 11 , , , cord-005453-4057qib7 7763 12 1 1 CD cord-005453-4057qib7 7763 13 AML AML NNP cord-005453-4057qib7 7763 14 ) ) -RRB- cord-005453-4057qib7 7763 15 . . . cord-005453-4057qib7 7764 1 Twenty twenty CD cord-005453-4057qib7 7764 2 ( ( -LRB- cord-005453-4057qib7 7764 3 39.2 39.2 CD cord-005453-4057qib7 7764 4 % % NN cord-005453-4057qib7 7764 5 ) ) -RRB- cord-005453-4057qib7 7764 6 out out IN cord-005453-4057qib7 7764 7 of of IN cord-005453-4057qib7 7764 8 51 51 CD cord-005453-4057qib7 7764 9 evaluable evaluable JJ cord-005453-4057qib7 7764 10 patients patient NNS cord-005453-4057qib7 7764 11 developed develop VBD cord-005453-4057qib7 7764 12 grade grade NN cord-005453-4057qib7 7764 13 2 2 CD cord-005453-4057qib7 7764 14 - - SYM cord-005453-4057qib7 7764 15 4 4 CD cord-005453-4057qib7 7764 16 acute acute JJ cord-005453-4057qib7 7764 17 GvHD GvHD NNP cord-005453-4057qib7 7764 18 . . . cord-005453-4057qib7 7765 1 The the DT cord-005453-4057qib7 7765 2 cumulative cumulative JJ cord-005453-4057qib7 7765 3 incidence incidence NN cord-005453-4057qib7 7765 4 of of IN cord-005453-4057qib7 7765 5 severe severe JJ cord-005453-4057qib7 7765 6 aGvHD agvhd NN cord-005453-4057qib7 7765 7 and and CC cord-005453-4057qib7 7765 8 moderatesevere moderatesevere NN cord-005453-4057qib7 7765 9 chronic chronic JJ cord-005453-4057qib7 7765 10 GvHD GvHD NNP cord-005453-4057qib7 7765 11 were be VBD cord-005453-4057qib7 7765 12 8.8 8.8 CD cord-005453-4057qib7 7765 13 % % NN cord-005453-4057qib7 7765 14 ( ( -LRB- cord-005453-4057qib7 7765 15 95 95 CD cord-005453-4057qib7 7765 16 % % NN cord-005453-4057qib7 7765 17 CI CI NNP cord-005453-4057qib7 7765 18 , , , cord-005453-4057qib7 7765 19 3.2 3.2 CD cord-005453-4057qib7 7765 20 - - SYM cord-005453-4057qib7 7765 21 17.9 17.9 CD cord-005453-4057qib7 7765 22 % % NN cord-005453-4057qib7 7765 23 ) ) -RRB- cord-005453-4057qib7 7765 24 and and CC cord-005453-4057qib7 7765 25 35.2 35.2 CD cord-005453-4057qib7 7765 26 % % NN cord-005453-4057qib7 7765 27 ( ( -LRB- cord-005453-4057qib7 7765 28 95 95 CD cord-005453-4057qib7 7765 29 % % NN cord-005453-4057qib7 7765 30 CI CI NNP cord-005453-4057qib7 7765 31 22.7 22.7 CD cord-005453-4057qib7 7765 32 - - HYPH cord-005453-4057qib7 7765 33 47.9 47.9 CD cord-005453-4057qib7 7765 34 % % NN cord-005453-4057qib7 7765 35 ) ) -RRB- cord-005453-4057qib7 7765 36 , , , cord-005453-4057qib7 7765 37 only only RB cord-005453-4057qib7 7765 38 5 5 CD cord-005453-4057qib7 7765 39 ( ( -LRB- cord-005453-4057qib7 7765 40 8.7 8.7 CD cord-005453-4057qib7 7765 41 % % NN cord-005453-4057qib7 7765 42 ) ) -RRB- cord-005453-4057qib7 7765 43 patients patient NNS cord-005453-4057qib7 7765 44 developed develop VBD cord-005453-4057qib7 7765 45 severe severe JJ cord-005453-4057qib7 7765 46 cGvHD cgvhd NN cord-005453-4057qib7 7765 47 . . . cord-005453-4057qib7 7766 1 Twenty twenty CD cord-005453-4057qib7 7766 2 - - HYPH cord-005453-4057qib7 7766 3 nine nine CD cord-005453-4057qib7 7766 4 patients patient NNS cord-005453-4057qib7 7766 5 ( ( -LRB- cord-005453-4057qib7 7766 6 56.8 56.8 CD cord-005453-4057qib7 7766 7 % % NN cord-005453-4057qib7 7766 8 ) ) -RRB- cord-005453-4057qib7 7766 9 discontinued discontinue VBN cord-005453-4057qib7 7766 10 immunosuppression immunosuppression NN cord-005453-4057qib7 7766 11 before before IN cord-005453-4057qib7 7766 12 the the DT cord-005453-4057qib7 7766 13 first first JJ cord-005453-4057qib7 7766 14 year year NN cord-005453-4057qib7 7766 15 of of IN cord-005453-4057qib7 7766 16 transplant transplant NN cord-005453-4057qib7 7766 17 . . . cord-005453-4057qib7 7767 1 The the DT cord-005453-4057qib7 7767 2 median median JJ cord-005453-4057qib7 7767 3 duration duration NN cord-005453-4057qib7 7767 4 of of IN cord-005453-4057qib7 7767 5 immunosuppression immunosuppression NN cord-005453-4057qib7 7767 6 for for IN cord-005453-4057qib7 7767 7 patients patient NNS cord-005453-4057qib7 7767 8 with with IN cord-005453-4057qib7 7767 9 moderate moderate JJ cord-005453-4057qib7 7767 10 - - HYPH cord-005453-4057qib7 7767 11 severe severe JJ cord-005453-4057qib7 7767 12 cGvHD cgvhd NN cord-005453-4057qib7 7767 13 was be VBD cord-005453-4057qib7 7767 14 488 488 CD cord-005453-4057qib7 7767 15 days day NNS cord-005453-4057qib7 7767 16 ( ( -LRB- cord-005453-4057qib7 7767 17 207 207 CD cord-005453-4057qib7 7767 18 - - HYPH cord-005453-4057qib7 7767 19 2046 2046 CD cord-005453-4057qib7 7767 20 ) ) -RRB- cord-005453-4057qib7 7767 21 . . . cord-005453-4057qib7 7768 1 At at IN cord-005453-4057qib7 7768 2 2 2 CD cord-005453-4057qib7 7768 3 years year NNS cord-005453-4057qib7 7768 4 non non JJ cord-005453-4057qib7 7768 5 - - JJ cord-005453-4057qib7 7768 6 relapse relapse JJ cord-005453-4057qib7 7768 7 mortality mortality NN cord-005453-4057qib7 7768 8 ( ( -LRB- cord-005453-4057qib7 7768 9 NRM NRM NNP cord-005453-4057qib7 7768 10 ) ) -RRB- cord-005453-4057qib7 7768 11 was be VBD cord-005453-4057qib7 7768 12 21.9 21.9 CD cord-005453-4057qib7 7768 13 % % NN cord-005453-4057qib7 7768 14 ( ( -LRB- cord-005453-4057qib7 7768 15 95 95 CD cord-005453-4057qib7 7768 16 % % NN cord-005453-4057qib7 7768 17 CI CI NNP cord-005453-4057qib7 7768 18 , , , cord-005453-4057qib7 7768 19 12.0 12.0 CD cord-005453-4057qib7 7768 20 - - HYPH cord-005453-4057qib7 7768 21 33.7 33.7 CD cord-005453-4057qib7 7768 22 % % NN cord-005453-4057qib7 7768 23 ) ) -RRB- cord-005453-4057qib7 7768 24 . . . cord-005453-4057qib7 7769 1 Thirty thirty CD cord-005453-4057qib7 7769 2 - - HYPH cord-005453-4057qib7 7769 3 nine nine CD cord-005453-4057qib7 7769 4 ( ( -LRB- cord-005453-4057qib7 7769 5 68 68 CD cord-005453-4057qib7 7769 6 % % NN cord-005453-4057qib7 7769 7 ) ) -RRB- cord-005453-4057qib7 7769 8 patients patient NNS cord-005453-4057qib7 7769 9 developed develop VBD cord-005453-4057qib7 7769 10 relevant relevant JJ cord-005453-4057qib7 7769 11 infectious infectious JJ cord-005453-4057qib7 7769 12 complications complication NNS cord-005453-4057qib7 7769 13 . . . cord-005453-4057qib7 7770 1 Two two CD cord-005453-4057qib7 7770 2 ( ( -LRB- cord-005453-4057qib7 7770 3 3 3 CD cord-005453-4057qib7 7770 4 % % NN cord-005453-4057qib7 7770 5 ) ) -RRB- cord-005453-4057qib7 7770 6 patients patient NNS cord-005453-4057qib7 7770 7 died die VBD cord-005453-4057qib7 7770 8 within within IN cord-005453-4057qib7 7770 9 the the DT cord-005453-4057qib7 7770 10 first first JJ cord-005453-4057qib7 7770 11 30 30 CD cord-005453-4057qib7 7770 12 days day NNS cord-005453-4057qib7 7770 13 due due JJ cord-005453-4057qib7 7770 14 to to TO cord-005453-4057qib7 7770 15 gram gram VB cord-005453-4057qib7 7770 16 negative negative JJ cord-005453-4057qib7 7770 17 blood blood NN cord-005453-4057qib7 7770 18 stream stream NN cord-005453-4057qib7 7770 19 infection infection NN cord-005453-4057qib7 7770 20 . . . cord-005453-4057qib7 7771 1 Eleven eleven CD cord-005453-4057qib7 7771 2 ( ( -LRB- cord-005453-4057qib7 7771 3 19.2 19.2 CD cord-005453-4057qib7 7771 4 % % NN cord-005453-4057qib7 7771 5 ) ) -RRB- cord-005453-4057qib7 7771 6 had have VBD cord-005453-4057qib7 7771 7 at at RB cord-005453-4057qib7 7771 8 least least RBS cord-005453-4057qib7 7771 9 two two CD cord-005453-4057qib7 7771 10 episodes episode NNS cord-005453-4057qib7 7771 11 of of IN cord-005453-4057qib7 7771 12 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 7771 13 ( ( -LRB- cord-005453-4057qib7 7771 14 CMV CMV NNP cord-005453-4057qib7 7771 15 ) ) -RRB- cord-005453-4057qib7 7771 16 reactivation reactivation NN cord-005453-4057qib7 7771 17 between between IN cord-005453-4057qib7 7771 18 day day NN cord-005453-4057qib7 7771 19 30 30 CD cord-005453-4057qib7 7771 20 and and CC cord-005453-4057qib7 7771 21 100 100 CD cord-005453-4057qib7 7771 22 . . . cord-005453-4057qib7 7772 1 Three three CD cord-005453-4057qib7 7772 2 ( ( -LRB- cord-005453-4057qib7 7772 3 5 5 CD cord-005453-4057qib7 7772 4 % % NN cord-005453-4057qib7 7772 5 ) ) -RRB- cord-005453-4057qib7 7773 1 patients patient NNS cord-005453-4057qib7 7773 2 developed develop VBD cord-005453-4057qib7 7773 3 CMV CMV NNP cord-005453-4057qib7 7773 4 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 7773 5 disease disease NN cord-005453-4057qib7 7773 6 , , , cord-005453-4057qib7 7773 7 2 2 CD cord-005453-4057qib7 7773 8 ( ( -LRB- cord-005453-4057qib7 7773 9 3 3 CD cord-005453-4057qib7 7773 10 % % NN cord-005453-4057qib7 7773 11 ) ) -RRB- cord-005453-4057qib7 7773 12 had have VBD cord-005453-4057qib7 7773 13 probable probable JJ cord-005453-4057qib7 7773 14 invasive invasive JJ cord-005453-4057qib7 7773 15 fungal fungal JJ cord-005453-4057qib7 7773 16 infection infection NN cord-005453-4057qib7 7773 17 and and CC cord-005453-4057qib7 7773 18 1 1 CD cord-005453-4057qib7 7773 19 ( ( -LRB- cord-005453-4057qib7 7773 20 1.7 1.7 CD cord-005453-4057qib7 7773 21 % % NN cord-005453-4057qib7 7773 22 ) ) -RRB- cord-005453-4057qib7 7773 23 , , , cord-005453-4057qib7 7773 24 post post JJ cord-005453-4057qib7 7773 25 - - JJ cord-005453-4057qib7 7773 26 transplant transplant JJ cord-005453-4057qib7 7773 27 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 7773 28 disorder disorder NN cord-005453-4057qib7 7773 29 associated associate VBN cord-005453-4057qib7 7773 30 to to IN cord-005453-4057qib7 7773 31 Epstein Epstein NNP cord-005453-4057qib7 7773 32 Barr Barr NNP cord-005453-4057qib7 7773 33 Virus Virus NNP cord-005453-4057qib7 7773 34 . . . cord-005453-4057qib7 7774 1 With with IN cord-005453-4057qib7 7774 2 a a DT cord-005453-4057qib7 7774 3 median median NN cord-005453-4057qib7 7774 4 follow follow NN cord-005453-4057qib7 7774 5 up up IN cord-005453-4057qib7 7774 6 of of IN cord-005453-4057qib7 7774 7 28 28 CD cord-005453-4057qib7 7774 8 months month NNS cord-005453-4057qib7 7774 9 for for IN cord-005453-4057qib7 7774 10 alive alive JJ cord-005453-4057qib7 7774 11 patients patient NNS cord-005453-4057qib7 7774 12 , , , cord-005453-4057qib7 7774 13 the the DT cord-005453-4057qib7 7774 14 GvHD gvhd NN cord-005453-4057qib7 7774 15 and and CC cord-005453-4057qib7 7774 16 relapse relapse VB cord-005453-4057qib7 7774 17 free free JJ cord-005453-4057qib7 7774 18 survival survival NN cord-005453-4057qib7 7774 19 ( ( -LRB- cord-005453-4057qib7 7774 20 GRFS GRFS NNP cord-005453-4057qib7 7774 21 ) ) -RRB- cord-005453-4057qib7 7774 22 at at IN cord-005453-4057qib7 7774 23 one one CD cord-005453-4057qib7 7774 24 year year NN cord-005453-4057qib7 7774 25 , , , cord-005453-4057qib7 7774 26 overall overall JJ cord-005453-4057qib7 7774 27 survival survival NN cord-005453-4057qib7 7774 28 ( ( -LRB- cord-005453-4057qib7 7774 29 OS OS NNP cord-005453-4057qib7 7774 30 ) ) -RRB- cord-005453-4057qib7 7774 31 and and CC cord-005453-4057qib7 7774 32 progression progression NN cord-005453-4057qib7 7774 33 free free JJ cord-005453-4057qib7 7774 34 survival survival NN cord-005453-4057qib7 7774 35 ( ( -LRB- cord-005453-4057qib7 7774 36 PFS PFS NNP cord-005453-4057qib7 7774 37 ) ) -RRB- cord-005453-4057qib7 7774 38 at at IN cord-005453-4057qib7 7774 39 two two CD cord-005453-4057qib7 7774 40 years year NNS cord-005453-4057qib7 7774 41 were be VBD cord-005453-4057qib7 7774 42 47.6 47.6 CD cord-005453-4057qib7 7774 43 % % NN cord-005453-4057qib7 7774 44 ( ( -LRB- cord-005453-4057qib7 7774 45 95 95 CD cord-005453-4057qib7 7774 46 % % NN cord-005453-4057qib7 7774 47 CI CI NNP cord-005453-4057qib7 7774 48 , , , cord-005453-4057qib7 7774 49 42.8 42.8 CD cord-005453-4057qib7 7774 50 - - SYM cord-005453-4057qib7 7774 51 52.2 52.2 CD cord-005453-4057qib7 7774 52 % % NN cord-005453-4057qib7 7774 53 ) ) -RRB- cord-005453-4057qib7 7774 54 , , , cord-005453-4057qib7 7774 55 59 59 CD cord-005453-4057qib7 7774 56 % % NN cord-005453-4057qib7 7774 57 ( ( -LRB- cord-005453-4057qib7 7774 58 95 95 CD cord-005453-4057qib7 7774 59 % % NN cord-005453-4057qib7 7774 60 CI CI NNP cord-005453-4057qib7 7774 61 , , , cord-005453-4057qib7 7774 62 54.5 54.5 CD cord-005453-4057qib7 7774 63 - - HYPH cord-005453-4057qib7 7774 64 63.2 63.2 CD cord-005453-4057qib7 7774 65 % % NN cord-005453-4057qib7 7774 66 ) ) -RRB- cord-005453-4057qib7 7774 67 and and CC cord-005453-4057qib7 7774 68 52 52 CD cord-005453-4057qib7 7774 69 % % NN cord-005453-4057qib7 7774 70 ( ( -LRB- cord-005453-4057qib7 7774 71 95 95 CD cord-005453-4057qib7 7774 72 % % NN cord-005453-4057qib7 7774 73 CI CI NNP cord-005453-4057qib7 7774 74 , , , cord-005453-4057qib7 7774 75 46.9 46.9 CD cord-005453-4057qib7 7774 76 - - SYM cord-005453-4057qib7 7774 77 56.5 56.5 CD cord-005453-4057qib7 7774 78 % % NN cord-005453-4057qib7 7774 79 ) ) -RRB- cord-005453-4057qib7 7774 80 , , , cord-005453-4057qib7 7774 81 respectively respectively RB cord-005453-4057qib7 7774 82 . . . cord-005453-4057qib7 7775 1 The the DT cord-005453-4057qib7 7775 2 relapse relapse NN cord-005453-4057qib7 7775 3 incidence incidence NN cord-005453-4057qib7 7775 4 at at IN cord-005453-4057qib7 7775 5 two two CD cord-005453-4057qib7 7775 6 years year NNS cord-005453-4057qib7 7775 7 was be VBD cord-005453-4057qib7 7775 8 26.3 26.3 CD cord-005453-4057qib7 7775 9 % % NN cord-005453-4057qib7 7775 10 ( ( -LRB- cord-005453-4057qib7 7775 11 95 95 CD cord-005453-4057qib7 7775 12 % % NN cord-005453-4057qib7 7775 13 CI CI NNP cord-005453-4057qib7 7775 14 14.7 14.7 CD cord-005453-4057qib7 7775 15 - - HYPH cord-005453-4057qib7 7775 16 39.4 39.4 CD cord-005453-4057qib7 7775 17 % % NN cord-005453-4057qib7 7775 18 ) ) -RRB- cord-005453-4057qib7 7775 19 . . . cord-005453-4057qib7 7776 1 Complete complete JJ cord-005453-4057qib7 7776 2 remission remission NN cord-005453-4057qib7 7776 3 at at IN cord-005453-4057qib7 7776 4 transplant transplant NN cord-005453-4057qib7 7776 5 was be VBD cord-005453-4057qib7 7776 6 associated associate VBN cord-005453-4057qib7 7776 7 with with IN cord-005453-4057qib7 7776 8 better well JJR cord-005453-4057qib7 7776 9 long long JJ cord-005453-4057qib7 7776 10 term term NN cord-005453-4057qib7 7776 11 survival survival NN cord-005453-4057qib7 7776 12 ( ( -LRB- cord-005453-4057qib7 7776 13 80 80 CD cord-005453-4057qib7 7776 14 % % NN cord-005453-4057qib7 7776 15 at at IN cord-005453-4057qib7 7776 16 2 2 CD cord-005453-4057qib7 7776 17 years year NNS cord-005453-4057qib7 7776 18 , , , cord-005453-4057qib7 7776 19 p p NN cord-005453-4057qib7 7776 20 < < XX cord-005453-4057qib7 7776 21 0.01 0.01 CD cord-005453-4057qib7 7776 22 ) ) -RRB- cord-005453-4057qib7 7776 23 . . . cord-005453-4057qib7 7777 1 HLA HLA NNP cord-005453-4057qib7 7777 2 disparity disparity NN cord-005453-4057qib7 7777 3 did do VBD cord-005453-4057qib7 7777 4 not not RB cord-005453-4057qib7 7777 5 affect affect VB cord-005453-4057qib7 7777 6 OS OS NNP cord-005453-4057qib7 7777 7 ( ( -LRB- cord-005453-4057qib7 7777 8 see see VB cord-005453-4057qib7 7777 9 image image NN cord-005453-4057qib7 7777 10 1A 1a CD cord-005453-4057qib7 7777 11 ) ) -RRB- cord-005453-4057qib7 7777 12 . . . cord-005453-4057qib7 7778 1 Conclusions conclusion NNS cord-005453-4057qib7 7778 2 : : : cord-005453-4057qib7 7779 1 The the DT cord-005453-4057qib7 7779 2 use use NN cord-005453-4057qib7 7779 3 of of IN cord-005453-4057qib7 7779 4 low low JJ cord-005453-4057qib7 7779 5 doses dose NNS cord-005453-4057qib7 7779 6 of of IN cord-005453-4057qib7 7779 7 ATG ATG NNP cord-005453-4057qib7 7779 8 - - HYPH cord-005453-4057qib7 7779 9 F F NNP cord-005453-4057qib7 7779 10 is be VBZ cord-005453-4057qib7 7779 11 protective protective JJ cord-005453-4057qib7 7779 12 against against IN cord-005453-4057qib7 7779 13 severe severe JJ cord-005453-4057qib7 7779 14 forms form NNS cord-005453-4057qib7 7779 15 of of IN cord-005453-4057qib7 7779 16 acute acute JJ cord-005453-4057qib7 7779 17 and and CC cord-005453-4057qib7 7779 18 chronic chronic JJ cord-005453-4057qib7 7779 19 GvHD gvhd NN cord-005453-4057qib7 7779 20 in in IN cord-005453-4057qib7 7779 21 a a DT cord-005453-4057qib7 7779 22 cohort cohort NN cord-005453-4057qib7 7779 23 with with IN cord-005453-4057qib7 7779 24 high high JJ cord-005453-4057qib7 7779 25 prevalence prevalence NN cord-005453-4057qib7 7779 26 of of IN cord-005453-4057qib7 7779 27 unrelated unrelated JJ cord-005453-4057qib7 7779 28 donors donor NNS cord-005453-4057qib7 7779 29 and and CC cord-005453-4057qib7 7779 30 a a DT cord-005453-4057qib7 7779 31 high high JJ cord-005453-4057qib7 7779 32 median median NN cord-005453-4057qib7 7779 33 age age NN cord-005453-4057qib7 7779 34 . . . cord-005453-4057qib7 7780 1 This this DT cord-005453-4057qib7 7780 2 strategy strategy NN cord-005453-4057qib7 7780 3 showed show VBD cord-005453-4057qib7 7780 4 good good JJ cord-005453-4057qib7 7780 5 results result NNS cord-005453-4057qib7 7780 6 in in IN cord-005453-4057qib7 7780 7 GRFS GRFS NNP cord-005453-4057qib7 7780 8 , , , cord-005453-4057qib7 7780 9 OS OS NNP cord-005453-4057qib7 7780 10 and and CC cord-005453-4057qib7 7780 11 PFS PFS NNP cord-005453-4057qib7 7780 12 in in IN cord-005453-4057qib7 7780 13 a a DT cord-005453-4057qib7 7780 14 population population NN cord-005453-4057qib7 7780 15 at at IN cord-005453-4057qib7 7780 16 high high JJ cord-005453-4057qib7 7780 17 risk risk NN cord-005453-4057qib7 7780 18 for for IN cord-005453-4057qib7 7780 19 developing develop VBG cord-005453-4057qib7 7780 20 GvHD gvhd NN cord-005453-4057qib7 7780 21 or or CC cord-005453-4057qib7 7780 22 relapse relapse NN cord-005453-4057qib7 7780 23 . . . cord-005453-4057qib7 7781 1 Disclosure disclosure NN cord-005453-4057qib7 7781 2 : : : cord-005453-4057qib7 7781 3 Nothing nothing NN cord-005453-4057qib7 7781 4 to to TO cord-005453-4057qib7 7781 5 declare declare VB cord-005453-4057qib7 7781 6 Performance performance NN cord-005453-4057qib7 7781 7 parameters parameter NNS cord-005453-4057qib7 7781 8 of of IN cord-005453-4057qib7 7781 9 a a DT cord-005453-4057qib7 7781 10 ngs ngs NN cord-005453-4057qib7 7781 11 - - HYPH cord-005453-4057qib7 7781 12 product product NN cord-005453-4057qib7 7781 13 for for IN cord-005453-4057qib7 7781 14 chimerism chimerism NN cord-005453-4057qib7 7781 15 monitoring monitoring NN cord-005453-4057qib7 7781 16 -applicable -applicable NN cord-005453-4057qib7 7782 1 in in IN cord-005453-4057qib7 7782 2 patients patient NNS cord-005453-4057qib7 7782 3 after after IN cord-005453-4057qib7 7782 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 7782 5 stem stem NN cord-005453-4057qib7 7782 6 cell cell NN cord-005453-4057qib7 7782 7 transplantation transplantation NN cord-005453-4057qib7 7782 8 Methods method NNS cord-005453-4057qib7 7782 9 : : : cord-005453-4057qib7 7782 10 For for IN cord-005453-4057qib7 7782 11 this this DT cord-005453-4057qib7 7782 12 purpose purpose NN cord-005453-4057qib7 7782 13 , , , cord-005453-4057qib7 7782 14 samples sample NNS cord-005453-4057qib7 7782 15 from from IN cord-005453-4057qib7 7782 16 patients patient NNS cord-005453-4057qib7 7782 17 with with IN cord-005453-4057qib7 7782 18 mixed mixed JJ cord-005453-4057qib7 7782 19 chimerism chimerism NN cord-005453-4057qib7 7782 20 ( ( -LRB- cord-005453-4057qib7 7782 21 MC MC NNP cord-005453-4057qib7 7782 22 ) ) -RRB- cord-005453-4057qib7 7782 23 with with IN cord-005453-4057qib7 7782 24 increasing increase VBG cord-005453-4057qib7 7782 25 amounts amount NNS cord-005453-4057qib7 7782 26 of of IN cord-005453-4057qib7 7782 27 recipient recipient NN cord-005453-4057qib7 7782 28 DNA DNA NNP cord-005453-4057qib7 7782 29 were be VBD cord-005453-4057qib7 7782 30 analyzed analyze VBN cord-005453-4057qib7 7782 31 and and CC cord-005453-4057qib7 7782 32 compared compare VBN cord-005453-4057qib7 7782 33 using use VBG cord-005453-4057qib7 7782 34 realtime realtime JJ cord-005453-4057qib7 7782 35 PCR PCR NNP cord-005453-4057qib7 7782 36 of of IN cord-005453-4057qib7 7782 37 insertions insertion NNS cord-005453-4057qib7 7782 38 / / SYM cord-005453-4057qib7 7782 39 deletions deletion NNS cord-005453-4057qib7 7782 40 ( ( -LRB- cord-005453-4057qib7 7782 41 indels indel NNS cord-005453-4057qib7 7782 42 ) ) -RRB- cord-005453-4057qib7 7782 43 , , , cord-005453-4057qib7 7782 44 fragment fragment NN cord-005453-4057qib7 7782 45 analysis analysis NN cord-005453-4057qib7 7782 46 of of IN cord-005453-4057qib7 7782 47 short short JJ cord-005453-4057qib7 7782 48 - - HYPH cord-005453-4057qib7 7782 49 tandem tandem NN cord-005453-4057qib7 7782 50 repeats repeat NNS cord-005453-4057qib7 7782 51 ( ( -LRB- cord-005453-4057qib7 7782 52 STR STR NNP cord-005453-4057qib7 7782 53 ) ) -RRB- cord-005453-4057qib7 7782 54 and and CC cord-005453-4057qib7 7782 55 NGS ngs NN cord-005453-4057qib7 7782 56 of of IN cord-005453-4057qib7 7782 57 indels indel NNS cord-005453-4057qib7 7782 58 . . . cord-005453-4057qib7 7783 1 Results result NNS cord-005453-4057qib7 7783 2 : : : cord-005453-4057qib7 7784 1 Whereas whereas IN cord-005453-4057qib7 7784 2 real real JJ cord-005453-4057qib7 7784 3 - - HYPH cord-005453-4057qib7 7784 4 time time NN cord-005453-4057qib7 7784 5 PCR PCR NNP cord-005453-4057qib7 7784 6 displayed display VBD cord-005453-4057qib7 7784 7 excellent excellent JJ cord-005453-4057qib7 7784 8 sensitivity sensitivity NN cord-005453-4057qib7 7784 9 down down RB cord-005453-4057qib7 7784 10 to to IN cord-005453-4057qib7 7784 11 0,01 0,01 NN cord-005453-4057qib7 7784 12 % % NN cord-005453-4057qib7 7784 13 MC MC NNP cord-005453-4057qib7 7784 14 , , , cord-005453-4057qib7 7784 15 but but CC cord-005453-4057qib7 7784 16 poor poor JJ cord-005453-4057qib7 7784 17 precision precision NN cord-005453-4057qib7 7784 18 above above IN cord-005453-4057qib7 7784 19 20 20 CD cord-005453-4057qib7 7784 20 % % NN cord-005453-4057qib7 7784 21 , , , cord-005453-4057qib7 7784 22 fragment fragment NN cord-005453-4057qib7 7784 23 analysis analysis NN cord-005453-4057qib7 7784 24 exhibited exhibit VBD cord-005453-4057qib7 7784 25 good good JJ cord-005453-4057qib7 7784 26 precision precision NN cord-005453-4057qib7 7784 27 with with IN cord-005453-4057qib7 7784 28 limited limited JJ cord-005453-4057qib7 7784 29 sensitivity sensitivity NN cord-005453-4057qib7 7784 30 ( ( -LRB- cord-005453-4057qib7 7784 31 > > NFP cord-005453-4057qib7 7784 32 2,5 2,5 CD cord-005453-4057qib7 7784 33 % % NN cord-005453-4057qib7 7784 34 ) ) -RRB- cord-005453-4057qib7 7784 35 . . . cord-005453-4057qib7 7785 1 In in IN cord-005453-4057qib7 7785 2 contrast contrast NN cord-005453-4057qib7 7785 3 , , , cord-005453-4057qib7 7785 4 NGS NGS NNP cord-005453-4057qib7 7785 5 chimerism chimerism NN cord-005453-4057qib7 7785 6 demonstrated demonstrate VBD cord-005453-4057qib7 7785 7 good good JJ cord-005453-4057qib7 7785 8 sensitivity sensitivity NN cord-005453-4057qib7 7785 9 , , , cord-005453-4057qib7 7785 10 with with IN cord-005453-4057qib7 7785 11 a a DT cord-005453-4057qib7 7785 12 limit limit NN cord-005453-4057qib7 7785 13 of of IN cord-005453-4057qib7 7785 14 detection detection NN cord-005453-4057qib7 7785 15 ( ( -LRB- cord-005453-4057qib7 7785 16 LOD lod NN cord-005453-4057qib7 7785 17 ) ) -RRB- cord-005453-4057qib7 7785 18 of of IN cord-005453-4057qib7 7785 19 0,1 0,1 CD cord-005453-4057qib7 7785 20 % % NN cord-005453-4057qib7 7785 21 MC MC NNP cord-005453-4057qib7 7785 22 , , , cord-005453-4057qib7 7785 23 and and CC cord-005453-4057qib7 7785 24 precision precision NN cord-005453-4057qib7 7785 25 throughout throughout IN cord-005453-4057qib7 7785 26 the the DT cord-005453-4057qib7 7785 27 whole whole JJ cord-005453-4057qib7 7785 28 spectrum spectrum NN cord-005453-4057qib7 7785 29 of of IN cord-005453-4057qib7 7785 30 patient patient NN cord-005453-4057qib7 7785 31 / / SYM cord-005453-4057qib7 7785 32 donor donor NN cord-005453-4057qib7 7785 33 mixed mixed JJ cord-005453-4057qib7 7785 34 chimerism chimerism NN cord-005453-4057qib7 7785 35 . . . cord-005453-4057qib7 7786 1 The the DT cord-005453-4057qib7 7786 2 NGS NGS NNP cord-005453-4057qib7 7786 3 chimerism chimerism NN cord-005453-4057qib7 7786 4 product product NN cord-005453-4057qib7 7786 5 ( ( -LRB- cord-005453-4057qib7 7786 6 Devyser Devyser NNP cord-005453-4057qib7 7786 7 Chimerism Chimerism NNP cord-005453-4057qib7 7786 8 ) ) -RRB- cord-005453-4057qib7 7786 9 exhibited exhibit VBD cord-005453-4057qib7 7786 10 at at IN cord-005453-4057qib7 7786 11 least least JJS cord-005453-4057qib7 7786 12 three three CD cord-005453-4057qib7 7786 13 ( ( -LRB- cord-005453-4057qib7 7786 14 average average JJ cord-005453-4057qib7 7786 15 eight eight CD cord-005453-4057qib7 7786 16 ) ) -RRB- cord-005453-4057qib7 7786 17 and and CC cord-005453-4057qib7 7786 18 at at IN cord-005453-4057qib7 7786 19 least least JJS cord-005453-4057qib7 7786 20 two two CD cord-005453-4057qib7 7786 21 ( ( -LRB- cord-005453-4057qib7 7786 22 average average JJ cord-005453-4057qib7 7786 23 5 5 CD cord-005453-4057qib7 7786 24 ) ) -RRB- cord-005453-4057qib7 7786 25 informative informative JJ cord-005453-4057qib7 7786 26 genetic genetic JJ cord-005453-4057qib7 7786 27 markers marker NNS cord-005453-4057qib7 7786 28 ( ( -LRB- cord-005453-4057qib7 7786 29 indels indel NNS cord-005453-4057qib7 7786 30 ) ) -RRB- cord-005453-4057qib7 7786 31 , , , cord-005453-4057qib7 7786 32 suitable suitable JJ cord-005453-4057qib7 7786 33 for for IN cord-005453-4057qib7 7786 34 monitoring monitor VBG cord-005453-4057qib7 7786 35 mixed mixed JJ cord-005453-4057qib7 7786 36 chimerism chimerism NN cord-005453-4057qib7 7786 37 of of IN cord-005453-4057qib7 7786 38 patients patient NNS cord-005453-4057qib7 7786 39 with with IN cord-005453-4057qib7 7786 40 their -PRON- PRP$ cord-005453-4057qib7 7786 41 corresponding corresponding JJ cord-005453-4057qib7 7786 42 matched match VBN cord-005453-4057qib7 7786 43 unrelated unrelated JJ cord-005453-4057qib7 7786 44 ( ( -LRB- cord-005453-4057qib7 7786 45 60 60 CD cord-005453-4057qib7 7786 46 ) ) -RRB- cord-005453-4057qib7 7786 47 or or CC cord-005453-4057qib7 7786 48 related relate VBN cord-005453-4057qib7 7786 49 ( ( -LRB- cord-005453-4057qib7 7786 50 56 56 CD cord-005453-4057qib7 7786 51 ) ) -RRB- cord-005453-4057qib7 7786 52 donor donor NN cord-005453-4057qib7 7786 53 samples sample NNS cord-005453-4057qib7 7786 54 . . . cord-005453-4057qib7 7787 1 In in IN cord-005453-4057qib7 7787 2 order order NN cord-005453-4057qib7 7787 3 to to TO cord-005453-4057qib7 7787 4 establish establish VB cord-005453-4057qib7 7787 5 the the DT cord-005453-4057qib7 7787 6 performance performance NN cord-005453-4057qib7 7787 7 of of IN cord-005453-4057qib7 7787 8 the the DT cord-005453-4057qib7 7787 9 separate separate JJ cord-005453-4057qib7 7787 10 techniques technique NNS cord-005453-4057qib7 7787 11 for for IN cord-005453-4057qib7 7787 12 determination determination NN cord-005453-4057qib7 7787 13 of of IN cord-005453-4057qib7 7787 14 mixed mixed JJ cord-005453-4057qib7 7787 15 chimerism chimerism NN cord-005453-4057qib7 7787 16 on on IN cord-005453-4057qib7 7787 17 retrospective retrospective JJ cord-005453-4057qib7 7787 18 patient patient NN cord-005453-4057qib7 7787 19 samples sample NNS cord-005453-4057qib7 7787 20 , , , cord-005453-4057qib7 7787 21 a a DT cord-005453-4057qib7 7787 22 cohort cohort NN cord-005453-4057qib7 7787 23 of of IN cord-005453-4057qib7 7787 24 27 27 CD cord-005453-4057qib7 7787 25 patient patient NN cord-005453-4057qib7 7787 26 monitoring monitoring NN cord-005453-4057qib7 7787 27 samples sample NNS cord-005453-4057qib7 7787 28 ( ( -LRB- cord-005453-4057qib7 7787 29 3 3 CD cord-005453-4057qib7 7787 30 - - SYM cord-005453-4057qib7 7787 31 7 7 CD cord-005453-4057qib7 7787 32 weeks week NNS cord-005453-4057qib7 7787 33 post post JJ cord-005453-4057qib7 7787 34 - - JJ cord-005453-4057qib7 7787 35 HSCT HSCT NNP cord-005453-4057qib7 7787 36 ) ) -RRB- cord-005453-4057qib7 7787 37 with with IN cord-005453-4057qib7 7787 38 low low JJ cord-005453-4057qib7 7787 39 ( ( -LRB- cord-005453-4057qib7 7787 40 < < NNP cord-005453-4057qib7 7787 41 5 5 CD cord-005453-4057qib7 7787 42 % % NN cord-005453-4057qib7 7787 43 ) ) -RRB- cord-005453-4057qib7 7787 44 , , , cord-005453-4057qib7 7787 45 intermediate intermediate JJ cord-005453-4057qib7 7787 46 or or CC cord-005453-4057qib7 7787 47 high high JJ cord-005453-4057qib7 7787 48 mixed mixed JJ cord-005453-4057qib7 7787 49 chimerism chimerism NN cord-005453-4057qib7 7787 50 ( ( -LRB- cord-005453-4057qib7 7787 51 > > NFP cord-005453-4057qib7 7787 52 20 20 CD cord-005453-4057qib7 7787 53 % % NN cord-005453-4057qib7 7787 54 ) ) -RRB- cord-005453-4057qib7 7787 55 were be VBD cord-005453-4057qib7 7787 56 included include VBN cord-005453-4057qib7 7787 57 and and CC cord-005453-4057qib7 7787 58 analyzed analyze VBN cord-005453-4057qib7 7787 59 . . . cord-005453-4057qib7 7788 1 DNA DNA NNP cord-005453-4057qib7 7788 2 from from IN cord-005453-4057qib7 7788 3 all all DT cord-005453-4057qib7 7788 4 monitoring monitoring NN cord-005453-4057qib7 7788 5 samples sample NNS cord-005453-4057qib7 7788 6 was be VBD cord-005453-4057qib7 7788 7 extracted extract VBN cord-005453-4057qib7 7788 8 from from IN cord-005453-4057qib7 7788 9 sorted sorted JJ cord-005453-4057qib7 7788 10 cell cell NN cord-005453-4057qib7 7788 11 fractions fraction NNS cord-005453-4057qib7 7788 12 . . . cord-005453-4057qib7 7789 1 The the DT cord-005453-4057qib7 7789 2 results result NNS cord-005453-4057qib7 7789 3 show show VBP cord-005453-4057qib7 7789 4 that that IN cord-005453-4057qib7 7789 5 although although IN cord-005453-4057qib7 7789 6 all all DT cord-005453-4057qib7 7789 7 evaluated evaluate VBN cord-005453-4057qib7 7789 8 techniques technique NNS cord-005453-4057qib7 7789 9 are be VBP cord-005453-4057qib7 7789 10 suitable suitable JJ cord-005453-4057qib7 7789 11 for for IN cord-005453-4057qib7 7789 12 monitoring monitor VBG cord-005453-4057qib7 7789 13 patient patient NN cord-005453-4057qib7 7789 14 / / SYM cord-005453-4057qib7 7789 15 donor donor NN cord-005453-4057qib7 7789 16 chimerism chimerism NN cord-005453-4057qib7 7789 17 after after IN cord-005453-4057qib7 7789 18 allogeneic allogeneic JJ cord-005453-4057qib7 7789 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 7789 20 stem stem NN cord-005453-4057qib7 7789 21 cell cell NN cord-005453-4057qib7 7789 22 transplantation transplantation NN cord-005453-4057qib7 7789 23 ( ( -LRB- cord-005453-4057qib7 7789 24 HSCT HSCT NNP cord-005453-4057qib7 7789 25 ) ) -RRB- cord-005453-4057qib7 7789 26 , , , cord-005453-4057qib7 7789 27 only only RB cord-005453-4057qib7 7789 28 the the DT cord-005453-4057qib7 7789 29 NGS NGS NNP cord-005453-4057qib7 7789 30 chimerism chimerism NN cord-005453-4057qib7 7789 31 product product NN cord-005453-4057qib7 7789 32 exhibits exhibit VBZ cord-005453-4057qib7 7789 33 high high JJ cord-005453-4057qib7 7789 34 sensitivity sensitivity NN cord-005453-4057qib7 7789 35 ( ( -LRB- cord-005453-4057qib7 7789 36 LOD lod NN cord-005453-4057qib7 7789 37 0,1 0,1 CD cord-005453-4057qib7 7789 38 % % NN cord-005453-4057qib7 7789 39 ) ) -RRB- cord-005453-4057qib7 7789 40 and and CC cord-005453-4057qib7 7789 41 a a DT cord-005453-4057qib7 7789 42 broad broad JJ cord-005453-4057qib7 7789 43 dynamic dynamic JJ cord-005453-4057qib7 7789 44 range range NN cord-005453-4057qib7 7789 45 ( ( -LRB- cord-005453-4057qib7 7789 46 detection detection NN cord-005453-4057qib7 7789 47 range range NN cord-005453-4057qib7 7789 48 0,1 0,1 CD cord-005453-4057qib7 7789 49 - - SYM cord-005453-4057qib7 7789 50 100 100 CD cord-005453-4057qib7 7789 51 % % NN cord-005453-4057qib7 7789 52 ) ) -RRB- cord-005453-4057qib7 7789 53 with with IN cord-005453-4057qib7 7789 54 good good JJ cord-005453-4057qib7 7789 55 precision precision NN cord-005453-4057qib7 7789 56 and and CC cord-005453-4057qib7 7789 57 accuracy accuracy NN cord-005453-4057qib7 7789 58 throughout throughout IN cord-005453-4057qib7 7789 59 the the DT cord-005453-4057qib7 7789 60 whole whole JJ cord-005453-4057qib7 7789 61 spectrum spectrum NN cord-005453-4057qib7 7789 62 of of IN cord-005453-4057qib7 7789 63 mixed mixed JJ cord-005453-4057qib7 7789 64 chimerism chimerism NN cord-005453-4057qib7 7789 65 ( ( -LRB- cord-005453-4057qib7 7789 66 % % NN cord-005453-4057qib7 7789 67 patient patient NN cord-005453-4057qib7 7789 68 / / SYM cord-005453-4057qib7 7789 69 donor donor NN cord-005453-4057qib7 7789 70 ) ) -RRB- cord-005453-4057qib7 7789 71 . . . cord-005453-4057qib7 7790 1 In in IN cord-005453-4057qib7 7790 2 addition addition NN cord-005453-4057qib7 7790 3 , , , cord-005453-4057qib7 7790 4 the the DT cord-005453-4057qib7 7790 5 NGS NGS NNP cord-005453-4057qib7 7790 6 chimerism chimerism NN cord-005453-4057qib7 7790 7 product product NN cord-005453-4057qib7 7790 8 employ employ VB cord-005453-4057qib7 7790 9 24 24 CD cord-005453-4057qib7 7790 10 non non JJ cord-005453-4057qib7 7790 11 - - JJ cord-005453-4057qib7 7790 12 population population JJ cord-005453-4057qib7 7790 13 dependent dependent JJ cord-005453-4057qib7 7790 14 highly highly RB cord-005453-4057qib7 7790 15 informative informative JJ cord-005453-4057qib7 7790 16 genetic genetic JJ cord-005453-4057qib7 7790 17 markers marker NNS cord-005453-4057qib7 7790 18 providing provide VBG cord-005453-4057qib7 7790 19 stable stable JJ cord-005453-4057qib7 7790 20 resolution resolution NN cord-005453-4057qib7 7790 21 power power NN cord-005453-4057qib7 7790 22 and and CC cord-005453-4057qib7 7790 23 thus thus RB cord-005453-4057qib7 7790 24 suitable suitable JJ cord-005453-4057qib7 7790 25 for for IN cord-005453-4057qib7 7790 26 monitoring monitor VBG cord-005453-4057qib7 7790 27 mixed mixed JJ cord-005453-4057qib7 7790 28 chimerism chimerism NN cord-005453-4057qib7 7790 29 . . . cord-005453-4057qib7 7791 1 Disclosure disclosure NN cord-005453-4057qib7 7791 2 : : : cord-005453-4057qib7 7791 3 Dan Dan NNP cord-005453-4057qib7 7791 4 Hauzenberger Hauzenberger NNP cord-005453-4057qib7 7791 5 is be VBZ cord-005453-4057qib7 7791 6 medical medical JJ cord-005453-4057qib7 7791 7 adviser adviser NN cord-005453-4057qib7 7791 8 at at IN cord-005453-4057qib7 7791 9 Devyser Devyser NNP cord-005453-4057qib7 7791 10 AB AB NNP cord-005453-4057qib7 7791 11 and and CC cord-005453-4057qib7 7791 12 shareholder shareholder NN cord-005453-4057qib7 7791 13 in in IN cord-005453-4057qib7 7791 14 Devyser Devyser NNP cord-005453-4057qib7 7791 15 Holding Holding NNP cord-005453-4057qib7 7791 16 Gender Gender NNP cord-005453-4057qib7 7791 17 distribution distribution NN cord-005453-4057qib7 7791 18 : : : cord-005453-4057qib7 7791 19 male male JJ cord-005453-4057qib7 7791 20 -59 -59 NNP cord-005453-4057qib7 7791 21 % % NN cord-005453-4057qib7 7791 22 ( ( -LRB- cord-005453-4057qib7 7791 23 n=58 n=58 NN cord-005453-4057qib7 7791 24 ) ) -RRB- cord-005453-4057qib7 7791 25 , , , cord-005453-4057qib7 7791 26 female female JJ cord-005453-4057qib7 7791 27 -41 -41 NNP cord-005453-4057qib7 7791 28 % % NN cord-005453-4057qib7 7791 29 ( ( -LRB- cord-005453-4057qib7 7791 30 n=41 n=41 RB cord-005453-4057qib7 7791 31 ) ) -RRB- cord-005453-4057qib7 7791 32 . . . cord-005453-4057qib7 7792 1 Age age NN cord-005453-4057qib7 7792 2 median median NN cord-005453-4057qib7 7793 1 -5,8 -5,8 JJS cord-005453-4057qib7 7793 2 years year NNS cord-005453-4057qib7 7793 3 old old JJ cord-005453-4057qib7 7793 4 ( ( -LRB- cord-005453-4057qib7 7793 5 8 8 CD cord-005453-4057qib7 7793 6 months month NNS cord-005453-4057qib7 7793 7 -17 -17 CD cord-005453-4057qib7 7793 8 ) ) -RRB- cord-005453-4057qib7 7793 9 . . . cord-005453-4057qib7 7794 1 Stem stem JJ cord-005453-4057qib7 7794 2 cell cell NN cord-005453-4057qib7 7794 3 source source NN cord-005453-4057qib7 7794 4 : : : cord-005453-4057qib7 7794 5 bone bone NN cord-005453-4057qib7 7794 6 marrow marrow NN cord-005453-4057qib7 7794 7 -80 -80 NNP cord-005453-4057qib7 7794 8 % % NN cord-005453-4057qib7 7794 9 ( ( -LRB- cord-005453-4057qib7 7794 10 n=81 n=81 JJ cord-005453-4057qib7 7794 11 ) ) -RRB- cord-005453-4057qib7 7794 12 , , , cord-005453-4057qib7 7794 13 peripheral peripheral JJ cord-005453-4057qib7 7794 14 blood blood NN cord-005453-4057qib7 7794 15 stem stem NN cord-005453-4057qib7 7794 16 cells cell NNS cord-005453-4057qib7 7794 17 -19 -19 IN cord-005453-4057qib7 7794 18 % % NN cord-005453-4057qib7 7794 19 ( ( -LRB- cord-005453-4057qib7 7794 20 n=19 n=19 NN cord-005453-4057qib7 7794 21 ) ) -RRB- cord-005453-4057qib7 7794 22 . . . cord-005453-4057qib7 7795 1 82 82 CD cord-005453-4057qib7 7795 2 patients patient NNS cord-005453-4057qib7 7795 3 ( ( -LRB- cord-005453-4057qib7 7795 4 83 83 CD cord-005453-4057qib7 7795 5 % % NN cord-005453-4057qib7 7795 6 ) ) -RRB- cord-005453-4057qib7 7795 7 received receive VBD cord-005453-4057qib7 7795 8 10/10 10/10 CD cord-005453-4057qib7 7795 9 matched match VBN cord-005453-4057qib7 7795 10 unrelated unrelated JJ cord-005453-4057qib7 7795 11 donors donor NNS cord-005453-4057qib7 7795 12 hematopoetic hematopoetic JJ cord-005453-4057qib7 7795 13 stem stem NN cord-005453-4057qib7 7795 14 cells cell NNS cord-005453-4057qib7 7795 15 transplantation transplantation NN cord-005453-4057qib7 7795 16 and and CC cord-005453-4057qib7 7795 17 17 17 CD cord-005453-4057qib7 7795 18 patients patient NNS cord-005453-4057qib7 7795 19 ( ( -LRB- cord-005453-4057qib7 7795 20 17 17 CD cord-005453-4057qib7 7795 21 % % NN cord-005453-4057qib7 7795 22 ) ) -RRB- cord-005453-4057qib7 7795 23 -9/10 -9/10 VBD cord-005453-4057qib7 7795 24 matched match VBN cord-005453-4057qib7 7795 25 unrelated unrelated JJ cord-005453-4057qib7 7795 26 donors donor NNS cord-005453-4057qib7 7795 27 hematopoetic hematopoetic JJ cord-005453-4057qib7 7795 28 stem stem NN cord-005453-4057qib7 7795 29 cells cell NNS cord-005453-4057qib7 7795 30 transplantation transplantation NN cord-005453-4057qib7 7795 31 . . . cord-005453-4057qib7 7796 1 Differences difference NNS cord-005453-4057qib7 7796 2 in in IN cord-005453-4057qib7 7796 3 the the DT cord-005453-4057qib7 7796 4 antigen antigen NN cord-005453-4057qib7 7796 5 blood blood NN cord-005453-4057qib7 7796 6 system system NN cord-005453-4057qib7 7796 7 : : : cord-005453-4057qib7 7796 8 single single JJ cord-005453-4057qib7 7796 9 group group NN cord-005453-4057qib7 7796 10 41 41 CD cord-005453-4057qib7 7796 11 % % NN cord-005453-4057qib7 7796 12 ( ( -LRB- cord-005453-4057qib7 7796 13 n=40 n=40 FW cord-005453-4057qib7 7796 14 ) ) -RRB- cord-005453-4057qib7 7796 15 , , , cord-005453-4057qib7 7796 16 minor minor JJ cord-005453-4057qib7 7796 17 32 32 CD cord-005453-4057qib7 7796 18 % % NN cord-005453-4057qib7 7796 19 ( ( -LRB- cord-005453-4057qib7 7796 20 n=31 n=31 NNP cord-005453-4057qib7 7796 21 ) ) -RRB- cord-005453-4057qib7 7796 22 , , , cord-005453-4057qib7 7796 23 major major JJ cord-005453-4057qib7 7796 24 20 20 CD cord-005453-4057qib7 7796 25 % % NN cord-005453-4057qib7 7796 26 ( ( -LRB- cord-005453-4057qib7 7796 27 n=18 n=18 RB cord-005453-4057qib7 7796 28 ) ) -RRB- cord-005453-4057qib7 7796 29 , , , cord-005453-4057qib7 7796 30 mixed mix VBN cord-005453-4057qib7 7796 31 11 11 CD cord-005453-4057qib7 7796 32 % % NN cord-005453-4057qib7 7796 33 ( ( -LRB- cord-005453-4057qib7 7796 34 n=9 n=9 NN cord-005453-4057qib7 7796 35 ) ) -RRB- cord-005453-4057qib7 7796 36 . . . cord-005453-4057qib7 7797 1 Age age NN cord-005453-4057qib7 7797 2 of of IN cord-005453-4057qib7 7797 3 donor donor NN cord-005453-4057qib7 7797 4 : : : cord-005453-4057qib7 7797 5 18 18 CD cord-005453-4057qib7 7797 6 - - SYM cord-005453-4057qib7 7797 7 25 25 CD cord-005453-4057qib7 7797 8 years year NNS cord-005453-4057qib7 7797 9 old old JJ cord-005453-4057qib7 7797 10 -25 -25 CD cord-005453-4057qib7 7797 11 % % NN cord-005453-4057qib7 7797 12 ( ( -LRB- cord-005453-4057qib7 7797 13 n=16 n=16 NNP cord-005453-4057qib7 7797 14 ) ) -RRB- cord-005453-4057qib7 7797 15 , , , cord-005453-4057qib7 7797 16 26 26 CD cord-005453-4057qib7 7797 17 - - SYM cord-005453-4057qib7 7797 18 35 35 CD cord-005453-4057qib7 7797 19 -42 -42 JJR cord-005453-4057qib7 7797 20 % % NN cord-005453-4057qib7 7797 21 ( ( -LRB- cord-005453-4057qib7 7797 22 n=27 n=27 NNP cord-005453-4057qib7 7797 23 ) ) -RRB- cord-005453-4057qib7 7797 24 , , , cord-005453-4057qib7 7797 25 36 36 CD cord-005453-4057qib7 7797 26 - - SYM cord-005453-4057qib7 7797 27 45 45 CD cord-005453-4057qib7 7797 28 -23 -23 CD cord-005453-4057qib7 7797 29 % % NN cord-005453-4057qib7 7797 30 ( ( -LRB- cord-005453-4057qib7 7797 31 n=15 n=15 NNP cord-005453-4057qib7 7797 32 ) ) -RRB- cord-005453-4057qib7 7797 33 , , , cord-005453-4057qib7 7797 34 46 46 CD cord-005453-4057qib7 7797 35 and and CC cord-005453-4057qib7 7797 36 more11 more11 NN cord-005453-4057qib7 7797 37 % % NN cord-005453-4057qib7 7797 38 ( ( -LRB- cord-005453-4057qib7 7797 39 n=7 n=7 NN cord-005453-4057qib7 7797 40 ) ) -RRB- cord-005453-4057qib7 7797 41 . . . cord-005453-4057qib7 7798 1 Gender gender NN cord-005453-4057qib7 7798 2 differences difference NNS cord-005453-4057qib7 7798 3 in in IN cord-005453-4057qib7 7798 4 donor donor NN cord-005453-4057qib7 7798 5 / / SYM cord-005453-4057qib7 7798 6 recipient recipient NN cord-005453-4057qib7 7798 7 : : : cord-005453-4057qib7 7798 8 male male JJ cord-005453-4057qib7 7798 9 / / SYM cord-005453-4057qib7 7798 10 female female JJ cord-005453-4057qib7 7798 11 25 25 CD cord-005453-4057qib7 7798 12 % % NN cord-005453-4057qib7 7798 13 ( ( -LRB- cord-005453-4057qib7 7798 14 n=24 n=24 NNP cord-005453-4057qib7 7798 15 ) ) -RRB- cord-005453-4057qib7 7798 16 , , , cord-005453-4057qib7 7798 17 female female JJ cord-005453-4057qib7 7798 18 / / SYM cord-005453-4057qib7 7798 19 male male JJ cord-005453-4057qib7 7798 20 18 18 CD cord-005453-4057qib7 7798 21 % % NN cord-005453-4057qib7 7798 22 ( ( -LRB- cord-005453-4057qib7 7798 23 n=18 n=18 RB cord-005453-4057qib7 7798 24 ) ) -RRB- cord-005453-4057qib7 7798 25 , , , cord-005453-4057qib7 7798 26 one one CD cord-005453-4057qib7 7798 27 sex sex NN cord-005453-4057qib7 7798 28 57 57 CD cord-005453-4057qib7 7798 29 % % NN cord-005453-4057qib7 7798 30 ( ( -LRB- cord-005453-4057qib7 7798 31 n=56 n=56 NN cord-005453-4057qib7 7798 32 ) ) -RRB- cord-005453-4057qib7 7798 33 . . . cord-005453-4057qib7 7799 1 We -PRON- PRP cord-005453-4057qib7 7799 2 also also RB cord-005453-4057qib7 7799 3 took take VBD cord-005453-4057qib7 7799 4 into into IN cord-005453-4057qib7 7799 5 account account NN cord-005453-4057qib7 7799 6 the the DT cord-005453-4057qib7 7799 7 impact impact NN cord-005453-4057qib7 7799 8 of of IN cord-005453-4057qib7 7799 9 gender gender NN cord-005453-4057qib7 7799 10 difference difference NN cord-005453-4057qib7 7799 11 and and CC cord-005453-4057qib7 7799 12 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 7799 13 serostatus serostatus NN cord-005453-4057qib7 7799 14 in in IN cord-005453-4057qib7 7799 15 the the DT cord-005453-4057qib7 7799 16 donor donor NN cord-005453-4057qib7 7799 17 / / SYM cord-005453-4057qib7 7799 18 recipient recipient NN cord-005453-4057qib7 7799 19 pair pair NN cord-005453-4057qib7 7799 20 . . . cord-005453-4057qib7 7800 1 Results result NNS cord-005453-4057qib7 7800 2 : : : cord-005453-4057qib7 7801 1 In in IN cord-005453-4057qib7 7801 2 10/10 10/10 CD cord-005453-4057qib7 7801 3 group group NN cord-005453-4057qib7 7801 4 the the DT cord-005453-4057qib7 7801 5 estimated estimate VBN cord-005453-4057qib7 7801 6 probability probability NN cord-005453-4057qib7 7801 7 of of IN cord-005453-4057qib7 7801 8 overall overall JJ cord-005453-4057qib7 7801 9 2-years 2-years CD cord-005453-4057qib7 7801 10 survive survive NN cord-005453-4057qib7 7801 11 was be VBD cord-005453-4057qib7 7801 12 76 76 CD cord-005453-4057qib7 7801 13 % % NN cord-005453-4057qib7 7801 14 and and CC cord-005453-4057qib7 7801 15 in in IN cord-005453-4057qib7 7801 16 the the DT cord-005453-4057qib7 7801 17 9/10 9/10 CD cord-005453-4057qib7 7801 18 group group NN cord-005453-4057qib7 7801 19 2-years 2-years CD cord-005453-4057qib7 7801 20 survive survive NN cord-005453-4057qib7 7801 21 was be VBD cord-005453-4057qib7 7801 22 63 63 CD cord-005453-4057qib7 7801 23 % % NN cord-005453-4057qib7 7801 24 . . . cord-005453-4057qib7 7802 1 The the DT cord-005453-4057qib7 7802 2 increase increase NN cord-005453-4057qib7 7802 3 in in IN cord-005453-4057qib7 7802 4 donor donor NN cord-005453-4057qib7 7802 5 age age NN cord-005453-4057qib7 7802 6 of of IN cord-005453-4057qib7 7802 7 10 10 CD cord-005453-4057qib7 7802 8 years year NNS cord-005453-4057qib7 7802 9 reduces reduce VBZ cord-005453-4057qib7 7802 10 the the DT cord-005453-4057qib7 7802 11 2-years 2-years CD cord-005453-4057qib7 7802 12 survive survive VBP cord-005453-4057qib7 7802 13 by by IN cord-005453-4057qib7 7802 14 9 9 CD cord-005453-4057qib7 7802 15 - - SYM cord-005453-4057qib7 7802 16 11 11 CD cord-005453-4057qib7 7802 17 % % NN cord-005453-4057qib7 7802 18 ( ( -LRB- cord-005453-4057qib7 7802 19 p=0,117 p=0,117 NNP cord-005453-4057qib7 7802 20 ) ) -RRB- cord-005453-4057qib7 7802 21 , , , cord-005453-4057qib7 7802 22 however however RB cord-005453-4057qib7 7802 23 , , , cord-005453-4057qib7 7802 24 the the DT cord-005453-4057qib7 7802 25 2-years 2-years CD cord-005453-4057qib7 7802 26 survive survive VBP cord-005453-4057qib7 7802 27 from from IN cord-005453-4057qib7 7802 28 donors donor NNS cord-005453-4057qib7 7802 29 over over IN cord-005453-4057qib7 7802 30 46 46 CD cord-005453-4057qib7 7802 31 years year NNS cord-005453-4057qib7 7802 32 old old JJ cord-005453-4057qib7 7802 33 was be VBD cord-005453-4057qib7 7802 34 100 100 CD cord-005453-4057qib7 7802 35 % % NN cord-005453-4057qib7 7802 36 . . . cord-005453-4057qib7 7803 1 We -PRON- PRP cord-005453-4057qib7 7803 2 have have VBP cord-005453-4057qib7 7803 3 found find VBN cord-005453-4057qib7 7803 4 no no DT cord-005453-4057qib7 7803 5 difference difference NN cord-005453-4057qib7 7803 6 between between IN cord-005453-4057qib7 7803 7 2-years 2-years CD cord-005453-4057qib7 7803 8 survive survive VBP cord-005453-4057qib7 7803 9 in in IN cord-005453-4057qib7 7803 10 transplants transplant NNS cord-005453-4057qib7 7803 11 from from IN cord-005453-4057qib7 7803 12 donors donor NNS cord-005453-4057qib7 7803 13 that that WDT cord-005453-4057qib7 7803 14 are be VBP cord-005453-4057qib7 7803 15 compatible/ compatible/ VBN cord-005453-4057qib7 7803 16 incompatible incompatible JJ cord-005453-4057qib7 7803 17 with with IN cord-005453-4057qib7 7803 18 the the DT cord-005453-4057qib7 7803 19 antigen antigen NN cord-005453-4057qib7 7803 20 blood blood NN cord-005453-4057qib7 7803 21 system system NN cord-005453-4057qib7 7803 22 , , , cord-005453-4057qib7 7803 23 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 7803 24 serostatus serostatus NN cord-005453-4057qib7 7803 25 , , , cord-005453-4057qib7 7803 26 or or CC cord-005453-4057qib7 7803 27 the the DT cord-005453-4057qib7 7803 28 gender gender NN cord-005453-4057qib7 7803 29 differences difference NNS cord-005453-4057qib7 7803 30 in in IN cord-005453-4057qib7 7803 31 donor/ donor/ CD cord-005453-4057qib7 7803 32 recipient recipient NN cord-005453-4057qib7 7803 33 . . . cord-005453-4057qib7 7804 1 In in IN cord-005453-4057qib7 7804 2 the the DT cord-005453-4057qib7 7804 3 study study NN cord-005453-4057qib7 7804 4 of of IN cord-005453-4057qib7 7804 5 donor donor NN cord-005453-4057qib7 7804 6 - - HYPH cord-005453-4057qib7 7804 7 related relate VBN cord-005453-4057qib7 7804 8 factors factor NNS cord-005453-4057qib7 7804 9 , , , cord-005453-4057qib7 7804 10 we -PRON- PRP cord-005453-4057qib7 7804 11 found find VBD cord-005453-4057qib7 7804 12 the the DT cord-005453-4057qib7 7804 13 negative negative JJ cord-005453-4057qib7 7804 14 impact impact NN cord-005453-4057qib7 7804 15 of of IN cord-005453-4057qib7 7804 16 an an DT cord-005453-4057qib7 7804 17 human human JJ cord-005453-4057qib7 7804 18 leucincompatibility leucincompatibility NN cord-005453-4057qib7 7804 19 ( ( -LRB- cord-005453-4057qib7 7804 20 9/10 9/10 CD cord-005453-4057qib7 7804 21 ) ) -RRB- cord-005453-4057qib7 7804 22 on on IN cord-005453-4057qib7 7804 23 the the DT cord-005453-4057qib7 7804 24 incidence incidence NN cord-005453-4057qib7 7804 25 of of IN cord-005453-4057qib7 7804 26 chronic chronic JJ cord-005453-4057qib7 7804 27 GVHD GVHD NNP cord-005453-4057qib7 7804 28 -29 -29 CD cord-005453-4057qib7 7804 29 % % NN cord-005453-4057qib7 7805 1 ( ( -LRB- cord-005453-4057qib7 7805 2 p p NN cord-005453-4057qib7 7805 3 = = SYM cord-005453-4057qib7 7805 4 0.019 0.019 CD cord-005453-4057qib7 7805 5 ) ) -RRB- cord-005453-4057qib7 7805 6 . . . cord-005453-4057qib7 7806 1 The the DT cord-005453-4057qib7 7806 2 combination combination NN cord-005453-4057qib7 7806 3 of of IN cord-005453-4057qib7 7806 4 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 7806 5 positive positive JJ cord-005453-4057qib7 7806 6 serostatus serostatus NN cord-005453-4057qib7 7806 7 of of IN cord-005453-4057qib7 7806 8 the the DT cord-005453-4057qib7 7806 9 donor donor NN cord-005453-4057qib7 7806 10 and and CC cord-005453-4057qib7 7806 11 the the DT cord-005453-4057qib7 7806 12 negative negative JJ cord-005453-4057qib7 7806 13 status status NN cord-005453-4057qib7 7806 14 of of IN cord-005453-4057qib7 7806 15 the the DT cord-005453-4057qib7 7806 16 recipient recipient NN cord-005453-4057qib7 7806 17 increases increase VBZ cord-005453-4057qib7 7806 18 the the DT cord-005453-4057qib7 7806 19 risk risk NN cord-005453-4057qib7 7806 20 of of IN cord-005453-4057qib7 7806 21 primary primary JJ cord-005453-4057qib7 7806 22 graft graft NN cord-005453-4057qib7 7806 23 rejection rejection NN cord-005453-4057qib7 7806 24 up up IN cord-005453-4057qib7 7806 25 to to TO cord-005453-4057qib7 7806 26 50 50 CD cord-005453-4057qib7 7806 27 % % NN cord-005453-4057qib7 7806 28 , , , cord-005453-4057qib7 7806 29 in in IN cord-005453-4057qib7 7806 30 comparison comparison NN cord-005453-4057qib7 7806 31 with with IN cord-005453-4057qib7 7806 32 others other NNS cord-005453-4057qib7 7806 33 ( ( -LRB- cord-005453-4057qib7 7806 34 p p NN cord-005453-4057qib7 7806 35 = = SYM cord-005453-4057qib7 7806 36 0.001 0.001 CD cord-005453-4057qib7 7806 37 ) ) -RRB- cord-005453-4057qib7 7806 38 . . . cord-005453-4057qib7 7807 1 Conclusions conclusion NNS cord-005453-4057qib7 7807 2 : : : cord-005453-4057qib7 7808 1 Our -PRON- PRP$ cord-005453-4057qib7 7808 2 study study NN cord-005453-4057qib7 7808 3 showed show VBD cord-005453-4057qib7 7808 4 the the DT cord-005453-4057qib7 7808 5 role role NN cord-005453-4057qib7 7808 6 of of IN cord-005453-4057qib7 7808 7 genetic genetic JJ cord-005453-4057qib7 7808 8 matching matching NN cord-005453-4057qib7 7808 9 on on IN cord-005453-4057qib7 7808 10 the the DT cord-005453-4057qib7 7808 11 HLA HLA NNP cord-005453-4057qib7 7808 12 system system NN cord-005453-4057qib7 7808 13 between between IN cord-005453-4057qib7 7808 14 the the DT cord-005453-4057qib7 7808 15 patient patient NN cord-005453-4057qib7 7808 16 and and CC cord-005453-4057qib7 7808 17 the the DT cord-005453-4057qib7 7808 18 unrelated unrelated JJ cord-005453-4057qib7 7808 19 donor donor NN cord-005453-4057qib7 7808 20 , , , cord-005453-4057qib7 7808 21 and and CC cord-005453-4057qib7 7808 22 the the DT cord-005453-4057qib7 7808 23 donors donor NNS cord-005453-4057qib7 7808 24 age age NN cord-005453-4057qib7 7808 25 value value NN cord-005453-4057qib7 7808 26 . . . cord-005453-4057qib7 7809 1 10/10 10/10 CD cord-005453-4057qib7 7809 2 transplants transplant NNS cord-005453-4057qib7 7809 3 have have VBP cord-005453-4057qib7 7809 4 better well JJR cord-005453-4057qib7 7809 5 outcome outcome NN cord-005453-4057qib7 7809 6 and and CC cord-005453-4057qib7 7809 7 lower low JJR cord-005453-4057qib7 7809 8 incidence incidence NN cord-005453-4057qib7 7809 9 of of IN cord-005453-4057qib7 7809 10 severe severe JJ cord-005453-4057qib7 7809 11 a. a. NN cord-005453-4057qib7 7809 12 GvHD GvHD NNP cord-005453-4057qib7 7809 13 and and CC cord-005453-4057qib7 7809 14 ch ch NNP cord-005453-4057qib7 7809 15 . . . cord-005453-4057qib7 7810 1 GVHD GVHD NNP cord-005453-4057qib7 7810 2 . . . cord-005453-4057qib7 7811 1 Younger young JJR cord-005453-4057qib7 7811 2 donor donor NN cord-005453-4057qib7 7811 3 increases increase NNS cord-005453-4057qib7 7811 4 2-years 2-years CD cord-005453-4057qib7 7811 5 survive survive VBP cord-005453-4057qib7 7811 6 , , , cord-005453-4057qib7 7811 7 but but CC cord-005453-4057qib7 7811 8 there there EX cord-005453-4057qib7 7811 9 is be VBZ cord-005453-4057qib7 7811 10 a a DT cord-005453-4057qib7 7811 11 significant significant JJ cord-005453-4057qib7 7811 12 increase increase NN cord-005453-4057qib7 7811 13 in in IN cord-005453-4057qib7 7811 14 2-years 2-years CD cord-005453-4057qib7 7811 15 survive survive VBP cord-005453-4057qib7 7811 16 if if IN cord-005453-4057qib7 7811 17 the the DT cord-005453-4057qib7 7811 18 donor donor NN cord-005453-4057qib7 7811 19 is be VBZ cord-005453-4057qib7 7811 20 over over IN cord-005453-4057qib7 7811 21 46 46 CD cord-005453-4057qib7 7811 22 years year NNS cord-005453-4057qib7 7811 23 old old JJ cord-005453-4057qib7 7811 24 . . . cord-005453-4057qib7 7812 1 Disclosure disclosure NN cord-005453-4057qib7 7812 2 : : : cord-005453-4057qib7 7812 3 Nothing nothing NN cord-005453-4057qib7 7812 4 to to TO cord-005453-4057qib7 7812 5 declare declare VB cord-005453-4057qib7 7812 6 Allogeneic Allogeneic NNP cord-005453-4057qib7 7812 7 stem stem NN cord-005453-4057qib7 7812 8 cell cell NN cord-005453-4057qib7 7812 9 transplantation transplantation NN cord-005453-4057qib7 7812 10 in in IN cord-005453-4057qib7 7812 11 chronic chronic JJ cord-005453-4057qib7 7812 12 myelomonocytic myelomonocytic JJ cord-005453-4057qib7 7812 13 leukemia leukemia NN cord-005453-4057qib7 7812 14 . . . cord-005453-4057qib7 7813 1 A a DT cord-005453-4057qib7 7813 2 single single JJ cord-005453-4057qib7 7813 3 center center NN cord-005453-4057qib7 7813 4 experience experience NN cord-005453-4057qib7 7814 1 Nine nine CD cord-005453-4057qib7 7814 2 patients patient NNS cord-005453-4057qib7 7814 3 ( ( -LRB- cord-005453-4057qib7 7814 4 45 45 CD cord-005453-4057qib7 7814 5 % % NN cord-005453-4057qib7 7814 6 ) ) -RRB- cord-005453-4057qib7 7814 7 relapsed relapse VBD cord-005453-4057qib7 7814 8 with with IN cord-005453-4057qib7 7814 9 a a DT cord-005453-4057qib7 7814 10 median median NN cord-005453-4057qib7 7814 11 of of IN cord-005453-4057qib7 7814 12 6,3 6,3 CD cord-005453-4057qib7 7814 13 months month NNS cord-005453-4057qib7 7814 14 ( ( -LRB- cord-005453-4057qib7 7814 15 1 1 CD cord-005453-4057qib7 7814 16 - - SYM cord-005453-4057qib7 7814 17 87 87 CD cord-005453-4057qib7 7814 18 ) ) -RRB- cord-005453-4057qib7 7814 19 with with IN cord-005453-4057qib7 7814 20 different different JJ cord-005453-4057qib7 7814 21 strategies strategy NNS cord-005453-4057qib7 7814 22 at at IN cord-005453-4057qib7 7814 23 this this DT cord-005453-4057qib7 7814 24 point point NN cord-005453-4057qib7 7814 25 : : : cord-005453-4057qib7 7814 26 in in IN cord-005453-4057qib7 7814 27 all all DT cord-005453-4057qib7 7814 28 cases case NNS cord-005453-4057qib7 7814 29 we -PRON- PRP cord-005453-4057qib7 7814 30 modulated modulate VBD cord-005453-4057qib7 7814 31 immunosuppression immunosuppression NN cord-005453-4057qib7 7814 32 , , , cord-005453-4057qib7 7814 33 in in IN cord-005453-4057qib7 7814 34 2 2 CD cord-005453-4057qib7 7814 35 cases case NNS cord-005453-4057qib7 7814 36 as as IN cord-005453-4057qib7 7814 37 the the DT cord-005453-4057qib7 7814 38 unique unique JJ cord-005453-4057qib7 7814 39 strategy strategy NN cord-005453-4057qib7 7814 40 , , , cord-005453-4057qib7 7814 41 in in IN cord-005453-4057qib7 7814 42 2 2 CD cord-005453-4057qib7 7814 43 cases case NNS cord-005453-4057qib7 7814 44 with with IN cord-005453-4057qib7 7814 45 donor donor NN cord-005453-4057qib7 7814 46 lymphocyte lymphocyte NN cord-005453-4057qib7 7814 47 infusion infusion NN cord-005453-4057qib7 7814 48 ( ( -LRB- cord-005453-4057qib7 7814 49 DLI DLI NNP cord-005453-4057qib7 7814 50 ) ) -RRB- cord-005453-4057qib7 7814 51 , , , cord-005453-4057qib7 7814 52 in in IN cord-005453-4057qib7 7814 53 3 3 CD cord-005453-4057qib7 7814 54 cases case NNS cord-005453-4057qib7 7814 55 we -PRON- PRP cord-005453-4057qib7 7814 56 employed employ VBD cord-005453-4057qib7 7814 57 hypometilating hypometilate VBG cord-005453-4057qib7 7814 58 agents agent NNS cord-005453-4057qib7 7814 59 ( ( -LRB- cord-005453-4057qib7 7814 60 HMA HMA NNP cord-005453-4057qib7 7814 61 ) ) -RRB- cord-005453-4057qib7 7814 62 and and CC cord-005453-4057qib7 7814 63 in in IN cord-005453-4057qib7 7814 64 2 2 CD cord-005453-4057qib7 7814 65 cases case NNS cord-005453-4057qib7 7814 66 with with IN cord-005453-4057qib7 7814 67 intensive intensive JJ cord-005453-4057qib7 7814 68 chemotherapy chemotherapy NN cord-005453-4057qib7 7814 69 , , , cord-005453-4057qib7 7814 70 reaching reach VBG cord-005453-4057qib7 7814 71 CR CR NNP cord-005453-4057qib7 7814 72 only only RB cord-005453-4057qib7 7814 73 in in IN cord-005453-4057qib7 7814 74 two two CD cord-005453-4057qib7 7814 75 patients patient NNS cord-005453-4057qib7 7814 76 , , , cord-005453-4057qib7 7814 77 one one CD cord-005453-4057qib7 7814 78 of of IN cord-005453-4057qib7 7814 79 them -PRON- PRP cord-005453-4057qib7 7814 80 after after IN cord-005453-4057qib7 7814 81 DLI DLI NNP cord-005453-4057qib7 7814 82 and and CC cord-005453-4057qib7 7814 83 the the DT cord-005453-4057qib7 7814 84 other other JJ cord-005453-4057qib7 7814 85 one one NN cord-005453-4057qib7 7814 86 after after IN cord-005453-4057qib7 7814 87 HMA HMA NNP cord-005453-4057qib7 7814 88 and and CC cord-005453-4057qib7 7814 89 consolidation consolidation NN cord-005453-4057qib7 7814 90 with with IN cord-005453-4057qib7 7814 91 a a DT cord-005453-4057qib7 7814 92 second second JJ cord-005453-4057qib7 7814 93 ASCT ASCT NNP cord-005453-4057qib7 7814 94 . . . cord-005453-4057qib7 7815 1 Eleven eleven CD cord-005453-4057qib7 7815 2 patients patient NNS cord-005453-4057qib7 7815 3 ( ( -LRB- cord-005453-4057qib7 7815 4 55 55 CD cord-005453-4057qib7 7815 5 % % NN cord-005453-4057qib7 7815 6 ) ) -RRB- cord-005453-4057qib7 7815 7 died die VBD cord-005453-4057qib7 7815 8 being be VBG cord-005453-4057qib7 7815 9 the the DT cord-005453-4057qib7 7815 10 relapse relapse NN cord-005453-4057qib7 7815 11 the the DT cord-005453-4057qib7 7815 12 main main JJ cord-005453-4057qib7 7815 13 cause cause NN cord-005453-4057qib7 7815 14 ( ( -LRB- cord-005453-4057qib7 7815 15 64 64 CD cord-005453-4057qib7 7815 16 % % NN cord-005453-4057qib7 7815 17 ) ) -RRB- cord-005453-4057qib7 7815 18 . . . cord-005453-4057qib7 7816 1 Transplant transplant NN cord-005453-4057qib7 7816 2 related relate VBN cord-005453-4057qib7 7816 3 mortality mortality NN cord-005453-4057qib7 7816 4 ( ( -LRB- cord-005453-4057qib7 7816 5 TRM TRM NNP cord-005453-4057qib7 7816 6 ) ) -RRB- cord-005453-4057qib7 7816 7 at at IN cord-005453-4057qib7 7816 8 +100 +100 NNS cord-005453-4057qib7 7816 9 were be VBD cord-005453-4057qib7 7816 10 5 5 CD cord-005453-4057qib7 7816 11 % % NN cord-005453-4057qib7 7816 12 and and CC cord-005453-4057qib7 7816 13 global global JJ cord-005453-4057qib7 7816 14 TRM TRM NNP cord-005453-4057qib7 7816 15 were be VBD cord-005453-4057qib7 7816 16 15 15 CD cord-005453-4057qib7 7816 17 % % NN cord-005453-4057qib7 7816 18 . . . cord-005453-4057qib7 7817 1 In in IN cord-005453-4057qib7 7817 2 the the DT cord-005453-4057qib7 7817 3 last last JJ cord-005453-4057qib7 7817 4 follow follow NN cord-005453-4057qib7 7817 5 - - HYPH cord-005453-4057qib7 7817 6 up up NN cord-005453-4057qib7 7817 7 , , , cord-005453-4057qib7 7817 8 9 9 CD cord-005453-4057qib7 7817 9 patients patient NNS cord-005453-4057qib7 7817 10 ( ( -LRB- cord-005453-4057qib7 7817 11 45 45 CD cord-005453-4057qib7 7817 12 % % NN cord-005453-4057qib7 7817 13 ) ) -RRB- cord-005453-4057qib7 7817 14 are be VBP cord-005453-4057qib7 7817 15 still still RB cord-005453-4057qib7 7817 16 alive alive JJ cord-005453-4057qib7 7817 17 , , , cord-005453-4057qib7 7817 18 8 8 CD cord-005453-4057qib7 7817 19 ( ( -LRB- cord-005453-4057qib7 7817 20 89 89 CD cord-005453-4057qib7 7817 21 % % NN cord-005453-4057qib7 7817 22 ) ) -RRB- cord-005453-4057qib7 7817 23 in in IN cord-005453-4057qib7 7817 24 CR CR NNP cord-005453-4057qib7 7817 25 and and CC cord-005453-4057qib7 7817 26 1 1 CD cord-005453-4057qib7 7817 27 ( ( -LRB- cord-005453-4057qib7 7817 28 11 11 CD cord-005453-4057qib7 7817 29 % % NN cord-005453-4057qib7 7817 30 ) ) -RRB- cord-005453-4057qib7 7817 31 in in IN cord-005453-4057qib7 7817 32 relapse relapse NN cord-005453-4057qib7 7817 33 situation situation NN cord-005453-4057qib7 7817 34 . . . cord-005453-4057qib7 7818 1 With with IN cord-005453-4057qib7 7818 2 a a DT cord-005453-4057qib7 7818 3 median median JJ cord-005453-4057qib7 7818 4 follow follow NN cord-005453-4057qib7 7818 5 - - HYPH cord-005453-4057qib7 7818 6 up up NN cord-005453-4057qib7 7818 7 of of IN cord-005453-4057qib7 7818 8 58 58 CD cord-005453-4057qib7 7818 9 months month NNS cord-005453-4057qib7 7818 10 ( ( -LRB- cord-005453-4057qib7 7818 11 5 5 CD cord-005453-4057qib7 7818 12 - - SYM cord-005453-4057qib7 7818 13 138 138 CD cord-005453-4057qib7 7818 14 ) ) -RRB- cord-005453-4057qib7 7818 15 , , , cord-005453-4057qib7 7818 16 the the DT cord-005453-4057qib7 7818 17 event event NN cord-005453-4057qib7 7818 18 free free JJ cord-005453-4057qib7 7818 19 survival survival NN cord-005453-4057qib7 7818 20 ( ( -LRB- cord-005453-4057qib7 7818 21 EFS EFS NNP cord-005453-4057qib7 7818 22 ) ) -RRB- cord-005453-4057qib7 7818 23 were be VBD cord-005453-4057qib7 7818 24 19 19 CD cord-005453-4057qib7 7818 25 months month NNS cord-005453-4057qib7 7818 26 ( ( -LRB- cord-005453-4057qib7 7818 27 5 5 CD cord-005453-4057qib7 7818 28 - - SYM cord-005453-4057qib7 7818 29 32 32 CD cord-005453-4057qib7 7818 30 ) ) -RRB- cord-005453-4057qib7 7818 31 and and CC cord-005453-4057qib7 7818 32 the the DT cord-005453-4057qib7 7818 33 overall overall JJ cord-005453-4057qib7 7818 34 survival survival NN cord-005453-4057qib7 7818 35 ( ( -LRB- cord-005453-4057qib7 7818 36 OS OS NNP cord-005453-4057qib7 7818 37 ) ) -RRB- cord-005453-4057qib7 7818 38 were be VBD cord-005453-4057qib7 7818 39 56 56 CD cord-005453-4057qib7 7818 40 months month NNS cord-005453-4057qib7 7818 41 ( ( -LRB- cord-005453-4057qib7 7818 42 0 0 CD cord-005453-4057qib7 7818 43 - - SYM cord-005453-4057qib7 7818 44 116 116 CD cord-005453-4057qib7 7818 45 ) ) -RRB- cord-005453-4057qib7 7818 46 . . . cord-005453-4057qib7 7819 1 We -PRON- PRP cord-005453-4057qib7 7819 2 observed observe VBD cord-005453-4057qib7 7819 3 advantage advantage NN cord-005453-4057qib7 7819 4 in in IN cord-005453-4057qib7 7819 5 terms term NNS cord-005453-4057qib7 7819 6 of of IN cord-005453-4057qib7 7819 7 OS os NN cord-005453-4057qib7 7819 8 in in IN cord-005453-4057qib7 7819 9 those those DT cord-005453-4057qib7 7819 10 patients patient NNS cord-005453-4057qib7 7819 11 that that WDT cord-005453-4057qib7 7819 12 reach reach VBP cord-005453-4057qib7 7819 13 CR CR NNP cord-005453-4057qib7 7819 14 at at IN cord-005453-4057qib7 7819 15 +100 +100 NNP cord-005453-4057qib7 7819 16 post post NN cord-005453-4057qib7 7819 17 ASCT ASCT NNP cord-005453-4057qib7 7819 18 and and CC cord-005453-4057qib7 7819 19 in in IN cord-005453-4057qib7 7819 20 those those DT cord-005453-4057qib7 7819 21 who who WP cord-005453-4057qib7 7819 22 develop develop VBP cord-005453-4057qib7 7819 23 chronic chronic JJ cord-005453-4057qib7 7819 24 GVCHD GVCHD NNP cord-005453-4057qib7 7819 25 ( ( -LRB- cord-005453-4057qib7 7819 26 p=0.065 p=0.065 NNP cord-005453-4057qib7 7820 1 and and CC cord-005453-4057qib7 7820 2 p=0.012 p=0.012 NNP cord-005453-4057qib7 7820 3 respectively respectively RB cord-005453-4057qib7 7820 4 ) ) -RRB- cord-005453-4057qib7 7821 1 Conclusions conclusion NNS cord-005453-4057qib7 7821 2 : : : cord-005453-4057qib7 7822 1 ASCT ASCT NNP cord-005453-4057qib7 7822 2 is be VBZ cord-005453-4057qib7 7822 3 still still RB cord-005453-4057qib7 7822 4 the the DT cord-005453-4057qib7 7822 5 only only JJ cord-005453-4057qib7 7822 6 curative curative JJ cord-005453-4057qib7 7822 7 option option NN cord-005453-4057qib7 7822 8 despite despite IN cord-005453-4057qib7 7822 9 the the DT cord-005453-4057qib7 7822 10 high high JJ cord-005453-4057qib7 7822 11 relapse relapse NN cord-005453-4057qib7 7822 12 rates rate NNS cord-005453-4057qib7 7822 13 . . . cord-005453-4057qib7 7823 1 To to TO cord-005453-4057qib7 7823 2 reach reach VB cord-005453-4057qib7 7823 3 CR CR NNP cord-005453-4057qib7 7823 4 at at IN cord-005453-4057qib7 7823 5 +100 +100 NNP cord-005453-4057qib7 7823 6 post post NN cord-005453-4057qib7 7823 7 ASCT ASCT NNP cord-005453-4057qib7 7823 8 and and CC cord-005453-4057qib7 7823 9 the the DT cord-005453-4057qib7 7823 10 development development NN cord-005453-4057qib7 7823 11 of of IN cord-005453-4057qib7 7823 12 chronic chronic JJ cord-005453-4057qib7 7823 13 GVHD GVHD NNP cord-005453-4057qib7 7823 14 seems seem VBZ cord-005453-4057qib7 7823 15 that that IN cord-005453-4057qib7 7823 16 they -PRON- PRP cord-005453-4057qib7 7823 17 confer confer VBP cord-005453-4057qib7 7823 18 advantage advantage NN cord-005453-4057qib7 7823 19 in in IN cord-005453-4057qib7 7823 20 terms term NNS cord-005453-4057qib7 7823 21 of of IN cord-005453-4057qib7 7823 22 OS OS NNP cord-005453-4057qib7 7823 23 . . . cord-005453-4057qib7 7824 1 The the DT cord-005453-4057qib7 7824 2 importance importance NN cord-005453-4057qib7 7824 3 of of IN cord-005453-4057qib7 7824 4 knowing know VBG cord-005453-4057qib7 7824 5 the the DT cord-005453-4057qib7 7824 6 molecular molecular JJ cord-005453-4057qib7 7824 7 profile profile NN cord-005453-4057qib7 7824 8 of of IN cord-005453-4057qib7 7824 9 the the DT cord-005453-4057qib7 7824 10 entities entity NNS cord-005453-4057qib7 7824 11 that that WDT cord-005453-4057qib7 7824 12 we -PRON- PRP cord-005453-4057qib7 7824 13 consider consider VBP cord-005453-4057qib7 7824 14 for for IN cord-005453-4057qib7 7824 15 ASCT ASCT NNP cord-005453-4057qib7 7824 16 . . . cord-005453-4057qib7 7825 1 Disclosure disclosure NN cord-005453-4057qib7 7825 2 This this DT cord-005453-4057qib7 7825 3 study study NN cord-005453-4057qib7 7825 4 documents document VBZ cord-005453-4057qib7 7825 5 a a DT cord-005453-4057qib7 7825 6 first first JJ cord-005453-4057qib7 7825 7 experience experience NN cord-005453-4057qib7 7825 8 of of IN cord-005453-4057qib7 7825 9 a a DT cord-005453-4057qib7 7825 10 cell cell NN cord-005453-4057qib7 7825 11 processing processing NN cord-005453-4057qib7 7825 12 lab lab NN cord-005453-4057qib7 7825 13 seeking seek VBG cord-005453-4057qib7 7825 14 to to TO cord-005453-4057qib7 7825 15 integrate integrate VB cord-005453-4057qib7 7825 16 process process NN cord-005453-4057qib7 7825 17 automation automation NN cord-005453-4057qib7 7825 18 technology technology NN cord-005453-4057qib7 7825 19 to to TO cord-005453-4057qib7 7825 20 wash wash VB cord-005453-4057qib7 7825 21 and and CC cord-005453-4057qib7 7825 22 volume volume NN cord-005453-4057qib7 7825 23 reduce reduce NN cord-005453-4057qib7 7825 24 products product NNS cord-005453-4057qib7 7825 25 which which WDT cord-005453-4057qib7 7825 26 can can MD cord-005453-4057qib7 7825 27 account account VB cord-005453-4057qib7 7825 28 for for IN cord-005453-4057qib7 7825 29 the the DT cord-005453-4057qib7 7825 30 initial initial JJ cord-005453-4057qib7 7825 31 material material NN cord-005453-4057qib7 7825 32 source source NN cord-005453-4057qib7 7825 33 volume volume NN cord-005453-4057qib7 7825 34 variability variability NN cord-005453-4057qib7 7825 35 , , , cord-005453-4057qib7 7825 36 product product NN cord-005453-4057qib7 7825 37 characteristics characteristic NNS cord-005453-4057qib7 7825 38 , , , cord-005453-4057qib7 7825 39 and and CC cord-005453-4057qib7 7825 40 number number NN cord-005453-4057qib7 7825 41 of of IN cord-005453-4057qib7 7825 42 bags bag NNS cord-005453-4057qib7 7825 43 . . . cord-005453-4057qib7 7826 1 Methods method NNS cord-005453-4057qib7 7826 2 : : : cord-005453-4057qib7 7826 3 Here here RB cord-005453-4057qib7 7826 4 we -PRON- PRP cord-005453-4057qib7 7826 5 report report VBP cord-005453-4057qib7 7826 6 the the DT cord-005453-4057qib7 7826 7 pre pre JJ cord-005453-4057qib7 7826 8 - - JJ cord-005453-4057qib7 7826 9 clinical clinical JJ cord-005453-4057qib7 7826 10 assessment assessment NN cord-005453-4057qib7 7826 11 of of IN cord-005453-4057qib7 7826 12 the the DT cord-005453-4057qib7 7826 13 lab lab NN cord-005453-4057qib7 7826 14 's 's POS cord-005453-4057qib7 7826 15 initial initial JJ cord-005453-4057qib7 7826 16 work work NN cord-005453-4057qib7 7826 17 with with IN cord-005453-4057qib7 7826 18 the the DT cord-005453-4057qib7 7826 19 LOVO LOVO NNP cord-005453-4057qib7 7826 20 Cell Cell NNP cord-005453-4057qib7 7826 21 Processing Processing NNP cord-005453-4057qib7 7826 22 System System NNP cord-005453-4057qib7 7826 23 for for IN cord-005453-4057qib7 7826 24 a a DT cord-005453-4057qib7 7826 25 5 5 CD cord-005453-4057qib7 7826 26 product product NN cord-005453-4057qib7 7826 27 experience experience NN cord-005453-4057qib7 7826 28 over over IN cord-005453-4057qib7 7826 29 2 2 CD cord-005453-4057qib7 7826 30 days day NNS cord-005453-4057qib7 7826 31 with with IN cord-005453-4057qib7 7826 32 1 1 CD cord-005453-4057qib7 7826 33 machine machine NN cord-005453-4057qib7 7826 34 . . . cord-005453-4057qib7 7827 1 This this DT cord-005453-4057qib7 7827 2 study study NN cord-005453-4057qib7 7827 3 used use VBD cord-005453-4057qib7 7827 4 products product NNS cord-005453-4057qib7 7827 5 intended intend VBN cord-005453-4057qib7 7827 6 for for IN cord-005453-4057qib7 7827 7 destruction destruction NN cord-005453-4057qib7 7827 8 . . . cord-005453-4057qib7 7828 1 The the DT cord-005453-4057qib7 7828 2 workflow workflow NN cord-005453-4057qib7 7828 3 used use VBN cord-005453-4057qib7 7828 4 parallel parallel JJ cord-005453-4057qib7 7828 5 and and CC cord-005453-4057qib7 7828 6 sequential sequential JJ cord-005453-4057qib7 7828 7 processing processing NN cord-005453-4057qib7 7828 8 schedule schedule NN cord-005453-4057qib7 7828 9 . . . cord-005453-4057qib7 7829 1 After after IN cord-005453-4057qib7 7829 2 water water NN cord-005453-4057qib7 7829 3 - - HYPH cord-005453-4057qib7 7829 4 bath bath NN cord-005453-4057qib7 7829 5 thawing thawing NN cord-005453-4057qib7 7829 6 , , , cord-005453-4057qib7 7829 7 bags bag NNS cord-005453-4057qib7 7829 8 were be VBD cord-005453-4057qib7 7829 9 sampled sample VBN cord-005453-4057qib7 7829 10 , , , cord-005453-4057qib7 7829 11 weighed weigh VBD cord-005453-4057qib7 7829 12 to to TO cord-005453-4057qib7 7829 13 determine determine VB cord-005453-4057qib7 7829 14 volume volume NN cord-005453-4057qib7 7829 15 , , , cord-005453-4057qib7 7829 16 and and CC cord-005453-4057qib7 7829 17 subsequently subsequently RB cord-005453-4057qib7 7829 18 connected connect VBN cord-005453-4057qib7 7829 19 to to IN cord-005453-4057qib7 7829 20 LOVO LOVO NNP cord-005453-4057qib7 7829 21 or or CC cord-005453-4057qib7 7829 22 pooled pool VBD cord-005453-4057qib7 7829 23 into into IN cord-005453-4057qib7 7829 24 a a DT cord-005453-4057qib7 7829 25 transfer transfer NN cord-005453-4057qib7 7829 26 pack pack NN cord-005453-4057qib7 7829 27 and and CC cord-005453-4057qib7 7829 28 then then RB cord-005453-4057qib7 7829 29 connected connect VBN cord-005453-4057qib7 7829 30 to to IN cord-005453-4057qib7 7829 31 LOVO LOVO NNP cord-005453-4057qib7 7829 32 . . . cord-005453-4057qib7 7830 1 The the DT cord-005453-4057qib7 7830 2 bags bag NNS cord-005453-4057qib7 7830 3 were be VBD cord-005453-4057qib7 7830 4 then then RB cord-005453-4057qib7 7830 5 diluted dilute VBN cord-005453-4057qib7 7830 6 1:1 1:1 CD cord-005453-4057qib7 7830 7 at at IN cord-005453-4057qib7 7830 8 50 50 CD cord-005453-4057qib7 7830 9 ml ml NNS cord-005453-4057qib7 7830 10 / / SYM cord-005453-4057qib7 7830 11 min min NN cord-005453-4057qib7 7830 12 with with IN cord-005453-4057qib7 7830 13 LOVO LOVO NNP cord-005453-4057qib7 7830 14 at at IN cord-005453-4057qib7 7830 15 +4 +4 NN cord-005453-4057qib7 7830 16 - - HYPH cord-005453-4057qib7 7830 17 8C 8c CD cord-005453-4057qib7 7830 18 using use VBG cord-005453-4057qib7 7830 19 6 6 CD cord-005453-4057qib7 7830 20 % % NN cord-005453-4057qib7 7830 21 Hydroxyethylstarch hydroxyethylstarch RB cord-005453-4057qib7 7830 22 130/0.4 130/0.4 CD cord-005453-4057qib7 7831 1 ( ( -LRB- cord-005453-4057qib7 7831 2 Voluven Voluven NNP cord-005453-4057qib7 7831 3 , , , cord-005453-4057qib7 7831 4 Fresenius Fresenius NNP cord-005453-4057qib7 7831 5 Kabi Kabi NNP cord-005453-4057qib7 7831 6 ) ) -RRB- cord-005453-4057qib7 7831 7 and and CC cord-005453-4057qib7 7831 8 processed process VBN cord-005453-4057qib7 7831 9 using use VBG cord-005453-4057qib7 7831 10 a a DT cord-005453-4057qib7 7831 11 3 3 CD cord-005453-4057qib7 7831 12 cycle cycle NN cord-005453-4057qib7 7831 13 procedure procedure NN cord-005453-4057qib7 7831 14 . . . cord-005453-4057qib7 7832 1 After after IN cord-005453-4057qib7 7832 2 processing process VBG cord-005453-4057qib7 7832 3 the the DT cord-005453-4057qib7 7832 4 bags bag NNS cord-005453-4057qib7 7832 5 were be VBD cord-005453-4057qib7 7832 6 weighed weigh VBN cord-005453-4057qib7 7832 7 for for IN cord-005453-4057qib7 7832 8 volume volume NN cord-005453-4057qib7 7832 9 , , , cord-005453-4057qib7 7832 10 sampled sample VBN cord-005453-4057qib7 7832 11 , , , cord-005453-4057qib7 7832 12 and and CC cord-005453-4057qib7 7832 13 stored store VBN cord-005453-4057qib7 7832 14 in in IN cord-005453-4057qib7 7832 15 a a DT cord-005453-4057qib7 7832 16 4 4 CD cord-005453-4057qib7 7832 17 - - HYPH cord-005453-4057qib7 7832 18 8C 8c CD cord-005453-4057qib7 7832 19 refrigerator refrigerator NN cord-005453-4057qib7 7832 20 in in IN cord-005453-4057qib7 7832 21 their -PRON- PRP$ cord-005453-4057qib7 7832 22 LOVO LOVO NNP cord-005453-4057qib7 7832 23 final final JJ cord-005453-4057qib7 7832 24 product product NN cord-005453-4057qib7 7832 25 bags bag NNS cord-005453-4057qib7 7832 26 . . . cord-005453-4057qib7 7833 1 Samples sample NNS cord-005453-4057qib7 7833 2 were be VBD cord-005453-4057qib7 7833 3 assessed assess VBN cord-005453-4057qib7 7833 4 from from IN cord-005453-4057qib7 7833 5 T=0 T=0 NNP cord-005453-4057qib7 7833 6 to to IN cord-005453-4057qib7 7833 7 T=24 T=24 NNP cord-005453-4057qib7 7833 8 hours hour NNS cord-005453-4057qib7 7833 9 . . . cord-005453-4057qib7 7834 1 Results result NNS cord-005453-4057qib7 7834 2 : : : cord-005453-4057qib7 7835 1 CD34 CD34 NNP cord-005453-4057qib7 7835 2 + + CC cord-005453-4057qib7 7835 3 viability viability NN cord-005453-4057qib7 7835 4 and and CC cord-005453-4057qib7 7835 5 absolute absolute JJ cord-005453-4057qib7 7835 6 counts count NNS cord-005453-4057qib7 7835 7 were be VBD cord-005453-4057qib7 7835 8 determined determine VBN cord-005453-4057qib7 7835 9 using use VBG cord-005453-4057qib7 7835 10 flow flow NN cord-005453-4057qib7 7835 11 cytometry cytometry NN cord-005453-4057qib7 7835 12 . . . cord-005453-4057qib7 7836 1 Processing processing NN cord-005453-4057qib7 7836 2 duration duration NN cord-005453-4057qib7 7836 3 and and CC cord-005453-4057qib7 7836 4 solution solution NN cord-005453-4057qib7 7836 5 volume volume NN cord-005453-4057qib7 7836 6 consumed consume VBN cord-005453-4057qib7 7836 7 was be VBD cord-005453-4057qib7 7836 8 determined determine VBN cord-005453-4057qib7 7836 9 by by IN cord-005453-4057qib7 7836 10 the the DT cord-005453-4057qib7 7836 11 LOVO LOVO NNP cord-005453-4057qib7 7836 12 's 's POS cord-005453-4057qib7 7836 13 sensors sensor NNS cord-005453-4057qib7 7836 14 and and CC cord-005453-4057qib7 7836 15 confirmed confirm VBN cord-005453-4057qib7 7836 16 by by IN cord-005453-4057qib7 7836 17 the the DT cord-005453-4057qib7 7836 18 operator operator NN cord-005453-4057qib7 7836 19 . . . cord-005453-4057qib7 7837 1 Data Data NNP cord-005453-4057qib7 7837 2 is be VBZ cord-005453-4057qib7 7837 3 presented present VBN cord-005453-4057qib7 7837 4 as as IN cord-005453-4057qib7 7837 5 a a DT cord-005453-4057qib7 7837 6 percentage percentage NN cord-005453-4057qib7 7837 7 relative relative JJ cord-005453-4057qib7 7837 8 to to IN cord-005453-4057qib7 7837 9 the the DT cord-005453-4057qib7 7837 10 post post NN cord-005453-4057qib7 7837 11 - - JJ cord-005453-4057qib7 7837 12 thaw thaw JJ cord-005453-4057qib7 7837 13 values value NNS cord-005453-4057qib7 7837 14 . . . cord-005453-4057qib7 7838 1 Note note VB cord-005453-4057qib7 7838 2 , , , cord-005453-4057qib7 7838 3 the the DT cord-005453-4057qib7 7838 4 values value NNS cord-005453-4057qib7 7838 5 presented present VBN cord-005453-4057qib7 7838 6 are be VBP cord-005453-4057qib7 7838 7 not not RB cord-005453-4057qib7 7838 8 total total JJ cord-005453-4057qib7 7838 9 process process NN cord-005453-4057qib7 7838 10 yields yield NNS cord-005453-4057qib7 7838 11 . . . cord-005453-4057qib7 7839 1 The the DT cord-005453-4057qib7 7839 2 results result NNS cord-005453-4057qib7 7839 3 focus focus VBP cord-005453-4057qib7 7839 4 on on IN cord-005453-4057qib7 7839 5 the the DT cord-005453-4057qib7 7839 6 LOVO LOVO NNP cord-005453-4057qib7 7839 7 processing processing NN cord-005453-4057qib7 7839 8 step step NN cord-005453-4057qib7 7839 9 . . . cord-005453-4057qib7 7840 1 Conclusions conclusion NNS cord-005453-4057qib7 7840 2 : : : cord-005453-4057qib7 7841 1 The the DT cord-005453-4057qib7 7841 2 operators operator NNS cord-005453-4057qib7 7841 3 easily easily RB cord-005453-4057qib7 7841 4 integrated integrate VBD cord-005453-4057qib7 7841 5 into into IN cord-005453-4057qib7 7841 6 the the DT cord-005453-4057qib7 7841 7 software software NN cord-005453-4057qib7 7841 8 to to TO cord-005453-4057qib7 7841 9 drive drive VB cord-005453-4057qib7 7841 10 the the DT cord-005453-4057qib7 7841 11 machine machine NN cord-005453-4057qib7 7841 12 . . . cord-005453-4057qib7 7842 1 The the DT cord-005453-4057qib7 7842 2 machine machine NN cord-005453-4057qib7 7842 3 demonstrated demonstrate VBD cord-005453-4057qib7 7842 4 it -PRON- PRP cord-005453-4057qib7 7842 5 's be VBZ cord-005453-4057qib7 7842 6 flexibility flexibility NN cord-005453-4057qib7 7842 7 with with IN cord-005453-4057qib7 7842 8 a a DT cord-005453-4057qib7 7842 9 wide wide JJ cord-005453-4057qib7 7842 10 - - HYPH cord-005453-4057qib7 7842 11 range range NN cord-005453-4057qib7 7842 12 of of IN cord-005453-4057qib7 7842 13 volumes volume NNS cord-005453-4057qib7 7842 14 , , , cord-005453-4057qib7 7842 15 cell cell NN cord-005453-4057qib7 7842 16 - - HYPH cord-005453-4057qib7 7842 17 inputs input NNS cord-005453-4057qib7 7842 18 , , , cord-005453-4057qib7 7842 19 and and CC cord-005453-4057qib7 7842 20 number number NN cord-005453-4057qib7 7842 21 of of IN cord-005453-4057qib7 7842 22 bags bag NNS cord-005453-4057qib7 7842 23 . . . cord-005453-4057qib7 7843 1 The the DT cord-005453-4057qib7 7843 2 LOVO LOVO NNP cord-005453-4057qib7 7843 3 produced produce VBD cord-005453-4057qib7 7843 4 products product NNS cord-005453-4057qib7 7843 5 which which WDT cord-005453-4057qib7 7843 6 meet meet VBP cord-005453-4057qib7 7843 7 our -PRON- PRP$ cord-005453-4057qib7 7843 8 specifications specification NNS cord-005453-4057qib7 7843 9 in in IN cord-005453-4057qib7 7843 10 a a DT cord-005453-4057qib7 7843 11 quick quick JJ cord-005453-4057qib7 7843 12 and and CC cord-005453-4057qib7 7843 13 reliable reliable JJ cord-005453-4057qib7 7843 14 manner manner NN cord-005453-4057qib7 7843 15 . . . cord-005453-4057qib7 7844 1 Further further JJ cord-005453-4057qib7 7844 2 work work NN cord-005453-4057qib7 7844 3 on on IN cord-005453-4057qib7 7844 4 this this DT cord-005453-4057qib7 7844 5 platform platform NN cord-005453-4057qib7 7844 6 will will MD cord-005453-4057qib7 7844 7 be be VB cord-005453-4057qib7 7844 8 performed perform VBN cord-005453-4057qib7 7844 9 to to TO cord-005453-4057qib7 7844 10 validate validate VB cord-005453-4057qib7 7844 11 and and CC cord-005453-4057qib7 7844 12 qualify qualify VB cord-005453-4057qib7 7844 13 this this DT cord-005453-4057qib7 7844 14 system system NN cord-005453-4057qib7 7844 15 for for IN cord-005453-4057qib7 7844 16 production production NN cord-005453-4057qib7 7844 17 use use NN cord-005453-4057qib7 7844 18 . . . cord-005453-4057qib7 7845 1 properties property NNS cord-005453-4057qib7 7845 2 . . . cord-005453-4057qib7 7846 1 The the DT cord-005453-4057qib7 7846 2 aim aim NN cord-005453-4057qib7 7846 3 of of IN cord-005453-4057qib7 7846 4 this this DT cord-005453-4057qib7 7846 5 study study NN cord-005453-4057qib7 7846 6 was be VBD cord-005453-4057qib7 7846 7 to to TO cord-005453-4057qib7 7846 8 evaluate evaluate VB cord-005453-4057qib7 7846 9 prospectively prospectively RB cord-005453-4057qib7 7846 10 the the DT cord-005453-4057qib7 7846 11 efficacy efficacy NN cord-005453-4057qib7 7846 12 of of IN cord-005453-4057qib7 7846 13 a a DT cord-005453-4057qib7 7846 14 FBM FBM NNP cord-005453-4057qib7 7846 15 protocol protocol NN cord-005453-4057qib7 7846 16 for for IN cord-005453-4057qib7 7846 17 the the DT cord-005453-4057qib7 7846 18 prevention prevention NN cord-005453-4057qib7 7846 19 of of IN cord-005453-4057qib7 7846 20 OM OM NNP cord-005453-4057qib7 7846 21 in in IN cord-005453-4057qib7 7846 22 patients patient NNS cord-005453-4057qib7 7846 23 undergoing undergo VBG cord-005453-4057qib7 7846 24 a a DT cord-005453-4057qib7 7846 25 HSCT HSCT NNP cord-005453-4057qib7 7846 26 . . . cord-005453-4057qib7 7847 1 Methods method NNS cord-005453-4057qib7 7847 2 : : : cord-005453-4057qib7 7848 1 All all DT cord-005453-4057qib7 7848 2 patients patient NNS cord-005453-4057qib7 7848 3 consecutively consecutively RB cord-005453-4057qib7 7848 4 who who WP cord-005453-4057qib7 7848 5 underwent undergo VBD cord-005453-4057qib7 7848 6 a a DT cord-005453-4057qib7 7848 7 HSCT HSCT NNP cord-005453-4057qib7 7848 8 at at IN cord-005453-4057qib7 7848 9 our -PRON- PRP$ cord-005453-4057qib7 7848 10 Center Center NNP cord-005453-4057qib7 7848 11 from from IN cord-005453-4057qib7 7848 12 201X 201X NNP cord-005453-4057qib7 7848 13 onwards onwards RB cord-005453-4057qib7 7848 14 received receive VBD cord-005453-4057qib7 7848 15 five five CD cord-005453-4057qib7 7848 16 weekly weekly JJ cord-005453-4057qib7 7848 17 FBM FBM NNP cord-005453-4057qib7 7848 18 sessions session NNS cord-005453-4057qib7 7848 19 with with IN cord-005453-4057qib7 7848 20 a a DT cord-005453-4057qib7 7848 21 bidiodic bidiodic JJ cord-005453-4057qib7 7848 22 laser laser NN cord-005453-4057qib7 7848 23 ( ( -LRB- cord-005453-4057qib7 7849 1 Lumix Lumix NNP cord-005453-4057qib7 7849 2 2 2 CD cord-005453-4057qib7 7849 3 ® ® NNPS cord-005453-4057qib7 7849 4 , , , cord-005453-4057qib7 7849 5 Prodent Prodent NNP cord-005453-4057qib7 7849 6 , , , cord-005453-4057qib7 7849 7 Italy Italy NNP cord-005453-4057qib7 7849 8 ) ) -RRB- cord-005453-4057qib7 7849 9 , , , cord-005453-4057qib7 7849 10 which which WDT cord-005453-4057qib7 7849 11 simultaneously simultaneously RB cord-005453-4057qib7 7849 12 emitted emit VBD cord-005453-4057qib7 7849 13 at at IN cord-005453-4057qib7 7849 14 650 650 CD cord-005453-4057qib7 7849 15 nm nm NN cord-005453-4057qib7 7849 16 and and CC cord-005453-4057qib7 7849 17 910 910 CD cord-005453-4057qib7 7849 18 nm nm NN cord-005453-4057qib7 7849 19 with with IN cord-005453-4057qib7 7849 20 a a DT cord-005453-4057qib7 7849 21 power power NN cord-005453-4057qib7 7849 22 of of IN cord-005453-4057qib7 7849 23 89mW 89mw CD cord-005453-4057qib7 7849 24 and and CC cord-005453-4057qib7 7849 25 energy energy NN cord-005453-4057qib7 7849 26 of of IN cord-005453-4057qib7 7849 27 4J 4j CD cord-005453-4057qib7 7849 28 per per IN cord-005453-4057qib7 7849 29 point point NN cord-005453-4057qib7 7849 30 . . . cord-005453-4057qib7 7850 1 The the DT cord-005453-4057qib7 7850 2 procedure procedure NN cord-005453-4057qib7 7850 3 started start VBD cord-005453-4057qib7 7850 4 the the DT cord-005453-4057qib7 7850 5 day day NN cord-005453-4057qib7 7850 6 before before IN cord-005453-4057qib7 7850 7 the the DT cord-005453-4057qib7 7850 8 beginning beginning NN cord-005453-4057qib7 7850 9 of of IN cord-005453-4057qib7 7850 10 the the DT cord-005453-4057qib7 7850 11 conditioning conditioning NN cord-005453-4057qib7 7850 12 regimen regimen NN cord-005453-4057qib7 7850 13 up up IN cord-005453-4057qib7 7850 14 to to IN cord-005453-4057qib7 7850 15 the the DT cord-005453-4057qib7 7850 16 tenth tenth JJ cord-005453-4057qib7 7850 17 day day NN cord-005453-4057qib7 7850 18 post post NN cord-005453-4057qib7 7850 19 - - NN cord-005453-4057qib7 7850 20 transplant transplant NN cord-005453-4057qib7 7850 21 . . . cord-005453-4057qib7 7851 1 The the DT cord-005453-4057qib7 7851 2 laser laser NN cord-005453-4057qib7 7851 3 was be VBD cord-005453-4057qib7 7851 4 applied apply VBN cord-005453-4057qib7 7851 5 in in IN cord-005453-4057qib7 7851 6 a a DT cord-005453-4057qib7 7851 7 defocused defocused JJ cord-005453-4057qib7 7851 8 mode mode NN cord-005453-4057qib7 7851 9 on on IN cord-005453-4057qib7 7851 10 each each DT cord-005453-4057qib7 7851 11 of of IN cord-005453-4057qib7 7851 12 the the DT cord-005453-4057qib7 7851 13 mucosal mucosal JJ cord-005453-4057qib7 7851 14 surfaces surface NNS cord-005453-4057qib7 7851 15 ( ( -LRB- cord-005453-4057qib7 7851 16 12 12 CD cord-005453-4057qib7 7851 17 areas area NNS cord-005453-4057qib7 7851 18 ) ) -RRB- cord-005453-4057qib7 7851 19 . . . cord-005453-4057qib7 7852 1 At at IN cord-005453-4057qib7 7852 2 each each DT cord-005453-4057qib7 7852 3 session session NN cord-005453-4057qib7 7852 4 , , , cord-005453-4057qib7 7852 5 the the DT cord-005453-4057qib7 7852 6 morphine morphine NN cord-005453-4057qib7 7852 7 dose dose NN cord-005453-4057qib7 7852 8 , , , cord-005453-4057qib7 7852 9 the the DT cord-005453-4057qib7 7852 10 OM om NN cord-005453-4057qib7 7852 11 level level NN cord-005453-4057qib7 7852 12 ( ( -LRB- cord-005453-4057qib7 7852 13 according accord VBG cord-005453-4057qib7 7852 14 to to IN cord-005453-4057qib7 7852 15 the the DT cord-005453-4057qib7 7852 16 WHO WHO NNP cord-005453-4057qib7 7852 17 scale scale NN cord-005453-4057qib7 7852 18 ) ) -RRB- cord-005453-4057qib7 7852 19 and and CC cord-005453-4057qib7 7852 20 pain pain NN cord-005453-4057qib7 7852 21 through through IN cord-005453-4057qib7 7852 22 a a DT cord-005453-4057qib7 7852 23 Numerical numerical JJ cord-005453-4057qib7 7852 24 Rating rating NN cord-005453-4057qib7 7852 25 Scale scale NN cord-005453-4057qib7 7852 26 ( ( -LRB- cord-005453-4057qib7 7852 27 NRS NRS NNP cord-005453-4057qib7 7852 28 ) ) -RRB- cord-005453-4057qib7 7852 29 were be VBD cord-005453-4057qib7 7852 30 recorded record VBN cord-005453-4057qib7 7852 31 . . . cord-005453-4057qib7 7853 1 Results result NNS cord-005453-4057qib7 7853 2 : : : cord-005453-4057qib7 7854 1 27 27 CD cord-005453-4057qib7 7854 2 consecutive consecutive JJ cord-005453-4057qib7 7854 3 patients patient NNS cord-005453-4057qib7 7854 4 ( ( -LRB- cord-005453-4057qib7 7854 5 19 19 CD cord-005453-4057qib7 7854 6 male/8 male/8 NN cord-005453-4057qib7 7854 7 female female NN cord-005453-4057qib7 7854 8 ) ) -RRB- cord-005453-4057qib7 7854 9 submitted submit VBD cord-005453-4057qib7 7854 10 to to IN cord-005453-4057qib7 7854 11 a a DT cord-005453-4057qib7 7854 12 HSCT HSCT NNP cord-005453-4057qib7 7854 13 were be VBD cord-005453-4057qib7 7854 14 analyzed analyze VBN cord-005453-4057qib7 7854 15 . . . cord-005453-4057qib7 7855 1 The the DT cord-005453-4057qib7 7855 2 median median JJ cord-005453-4057qib7 7855 3 age age NN cord-005453-4057qib7 7855 4 was be VBD cord-005453-4057qib7 7855 5 44 44 CD cord-005453-4057qib7 7855 6 years year NNS cord-005453-4057qib7 7856 1 ( ( -LRB- cord-005453-4057qib7 7856 2 range range NNP cord-005453-4057qib7 7856 3 4 4 CD cord-005453-4057qib7 7856 4 - - SYM cord-005453-4057qib7 7856 5 66 66 CD cord-005453-4057qib7 7856 6 ) ) -RRB- cord-005453-4057qib7 7856 7 . . . cord-005453-4057qib7 7857 1 Eighteen eighteen CD cord-005453-4057qib7 7857 2 patients patient NNS cord-005453-4057qib7 7857 3 had have VBD cord-005453-4057qib7 7857 4 acute acute JJ cord-005453-4057qib7 7857 5 leukemia leukemia NN cord-005453-4057qib7 7857 6 , , , cord-005453-4057qib7 7857 7 3 3 CD cord-005453-4057qib7 7857 8 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 7857 9 syndromes syndrome NNS cord-005453-4057qib7 7857 10 , , , cord-005453-4057qib7 7857 11 6 6 CD cord-005453-4057qib7 7857 12 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 7857 13 diseases disease NNS cord-005453-4057qib7 7857 14 . . . cord-005453-4057qib7 7858 1 The the DT cord-005453-4057qib7 7858 2 median median JJ cord-005453-4057qib7 7858 3 number number NN cord-005453-4057qib7 7858 4 of of IN cord-005453-4057qib7 7858 5 treatment treatment NN cord-005453-4057qib7 7858 6 lines line NNS cord-005453-4057qib7 7858 7 before before IN cord-005453-4057qib7 7858 8 HSCT HSCT NNP cord-005453-4057qib7 7858 9 was be VBD cord-005453-4057qib7 7858 10 2 2 CD cord-005453-4057qib7 7858 11 ( ( -LRB- cord-005453-4057qib7 7858 12 range range NNP cord-005453-4057qib7 7858 13 1 1 CD cord-005453-4057qib7 7858 14 - - SYM cord-005453-4057qib7 7858 15 5 5 CD cord-005453-4057qib7 7858 16 ) ) -RRB- cord-005453-4057qib7 7858 17 . . . cord-005453-4057qib7 7859 1 At at IN cord-005453-4057qib7 7859 2 transplant transplant NN cord-005453-4057qib7 7859 3 , , , cord-005453-4057qib7 7859 4 13 13 CD cord-005453-4057qib7 7859 5 patients patient NNS cord-005453-4057qib7 7859 6 had have VBD cord-005453-4057qib7 7859 7 advanced advanced JJ cord-005453-4057qib7 7859 8 disease disease NN cord-005453-4057qib7 7859 9 . . . cord-005453-4057qib7 7860 1 The the DT cord-005453-4057qib7 7860 2 myeloablative myeloablative JJ cord-005453-4057qib7 7860 3 conditioning conditioning NN cord-005453-4057qib7 7860 4 regimen regimen NN cord-005453-4057qib7 7860 5 MAC MAC NNP cord-005453-4057qib7 7861 1 ( ( -LRB- cord-005453-4057qib7 7861 2 Thyotepa Thyotepa NNP cord-005453-4057qib7 7861 3 , , , cord-005453-4057qib7 7861 4 Busulphan Busulphan NNP cord-005453-4057qib7 7861 5 , , , cord-005453-4057qib7 7861 6 Fludarabine Fludarabine NNP cord-005453-4057qib7 7861 7 ) ) -RRB- cord-005453-4057qib7 7861 8 was be VBD cord-005453-4057qib7 7861 9 employed employ VBN cord-005453-4057qib7 7861 10 in in IN cord-005453-4057qib7 7861 11 17 17 CD cord-005453-4057qib7 7861 12 patients patient NNS cord-005453-4057qib7 7861 13 ; ; : cord-005453-4057qib7 7861 14 the the DT cord-005453-4057qib7 7861 15 same same JJ cord-005453-4057qib7 7861 16 conditioning conditioning NN cord-005453-4057qib7 7861 17 , , , cord-005453-4057qib7 7861 18 with with IN cord-005453-4057qib7 7861 19 a a DT cord-005453-4057qib7 7861 20 reduced reduced JJ cord-005453-4057qib7 7861 21 dose dose NN cord-005453-4057qib7 7861 22 of of IN cord-005453-4057qib7 7861 23 Busulphan Busulphan NNP cord-005453-4057qib7 7861 24 ( ( -LRB- cord-005453-4057qib7 7861 25 RIC RIC NNP cord-005453-4057qib7 7861 26 ) ) -RRB- cord-005453-4057qib7 7861 27 , , , cord-005453-4057qib7 7861 28 was be VBD cord-005453-4057qib7 7861 29 infused infuse VBN cord-005453-4057qib7 7861 30 in in IN cord-005453-4057qib7 7861 31 10 10 CD cord-005453-4057qib7 7861 32 patients patient NNS cord-005453-4057qib7 7861 33 . . . cord-005453-4057qib7 7862 1 Seven seven CD cord-005453-4057qib7 7862 2 patients patient NNS cord-005453-4057qib7 7862 3 ( ( -LRB- cord-005453-4057qib7 7862 4 26 26 CD cord-005453-4057qib7 7862 5 % % NN cord-005453-4057qib7 7862 6 ) ) -RRB- cord-005453-4057qib7 7862 7 had have VBD cord-005453-4057qib7 7862 8 no no DT cord-005453-4057qib7 7862 9 evidence evidence NN cord-005453-4057qib7 7862 10 of of IN cord-005453-4057qib7 7862 11 OM OM NNP cord-005453-4057qib7 7862 12 . . . cord-005453-4057qib7 7863 1 The the DT cord-005453-4057qib7 7863 2 incidence incidence NN cord-005453-4057qib7 7863 3 of of IN cord-005453-4057qib7 7863 4 grade grade NN cord-005453-4057qib7 7863 5 II II NNP cord-005453-4057qib7 7863 6 - - HYPH cord-005453-4057qib7 7863 7 IV IV NNP cord-005453-4057qib7 7863 8 OM OM NNP cord-005453-4057qib7 7863 9 was be VBD cord-005453-4057qib7 7863 10 65 65 CD cord-005453-4057qib7 7863 11 % % NN cord-005453-4057qib7 7863 12 in in IN cord-005453-4057qib7 7863 13 the the DT cord-005453-4057qib7 7863 14 group group NN cord-005453-4057qib7 7863 15 of of IN cord-005453-4057qib7 7863 16 patients patient NNS cord-005453-4057qib7 7863 17 receiving receive VBG cord-005453-4057qib7 7863 18 MAC MAC NNP cord-005453-4057qib7 7863 19 and and CC cord-005453-4057qib7 7863 20 the the DT cord-005453-4057qib7 7863 21 median median JJ cord-005453-4057qib7 7863 22 duration duration NN cord-005453-4057qib7 7863 23 12 12 CD cord-005453-4057qib7 7863 24 days day NNS cord-005453-4057qib7 7863 25 ( ( -LRB- cord-005453-4057qib7 7863 26 range range NNP cord-005453-4057qib7 7863 27 3 3 CD cord-005453-4057qib7 7863 28 - - SYM cord-005453-4057qib7 7863 29 28 28 CD cord-005453-4057qib7 7863 30 ) ) -RRB- cord-005453-4057qib7 7863 31 ; ; : cord-005453-4057qib7 7863 32 grade grade NN cord-005453-4057qib7 7863 33 4 4 CD cord-005453-4057qib7 7863 34 OM om NN cord-005453-4057qib7 7863 35 was be VBD cord-005453-4057qib7 7863 36 observed observe VBN cord-005453-4057qib7 7863 37 , , , cord-005453-4057qib7 7863 38 for for IN cord-005453-4057qib7 7863 39 1 1 CD cord-005453-4057qib7 7863 40 day day NN cord-005453-4057qib7 7863 41 , , , cord-005453-4057qib7 7863 42 in in IN cord-005453-4057qib7 7863 43 1 1 CD cord-005453-4057qib7 7863 44 patient patient NN cord-005453-4057qib7 7863 45 . . . cord-005453-4057qib7 7864 1 In in IN cord-005453-4057qib7 7864 2 the the DT cord-005453-4057qib7 7864 3 RIC RIC NNP cord-005453-4057qib7 7864 4 group group NN cord-005453-4057qib7 7864 5 the the DT cord-005453-4057qib7 7864 6 incidence incidence NN cord-005453-4057qib7 7864 7 of of IN cord-005453-4057qib7 7864 8 OM OM NNP cord-005453-4057qib7 7864 9 was be VBD cord-005453-4057qib7 7864 10 50 50 CD cord-005453-4057qib7 7864 11 % % NN cord-005453-4057qib7 7864 12 , , , cord-005453-4057qib7 7864 13 the the DT cord-005453-4057qib7 7864 14 median median JJ cord-005453-4057qib7 7864 15 duration duration NN cord-005453-4057qib7 7864 16 11 11 CD cord-005453-4057qib7 7864 17 days day NNS cord-005453-4057qib7 7864 18 ( ( -LRB- cord-005453-4057qib7 7864 19 range range NNP cord-005453-4057qib7 7864 20 7 7 CD cord-005453-4057qib7 7864 21 - - SYM cord-005453-4057qib7 7864 22 16 16 CD cord-005453-4057qib7 7864 23 ) ) -RRB- cord-005453-4057qib7 7864 24 ; ; : cord-005453-4057qib7 7864 25 no no DT cord-005453-4057qib7 7864 26 patient patient NN cord-005453-4057qib7 7864 27 had have VBD cord-005453-4057qib7 7864 28 evidence evidence NN cord-005453-4057qib7 7864 29 of of IN cord-005453-4057qib7 7864 30 grade grade NN cord-005453-4057qib7 7864 31 IV IV NNP cord-005453-4057qib7 7864 32 OM OM NNP cord-005453-4057qib7 7864 33 . . . cord-005453-4057qib7 7865 1 In in IN cord-005453-4057qib7 7865 2 the the DT cord-005453-4057qib7 7865 3 whole whole JJ cord-005453-4057qib7 7865 4 population population NN cord-005453-4057qib7 7865 5 , , , cord-005453-4057qib7 7865 6 the the DT cord-005453-4057qib7 7865 7 maximum maximum JJ cord-005453-4057qib7 7865 8 NRS NRS NNP cord-005453-4057qib7 7865 9 value value NN cord-005453-4057qib7 7865 10 was be VBD cord-005453-4057qib7 7865 11 4 4 CD cord-005453-4057qib7 7865 12 . . . cord-005453-4057qib7 7866 1 Morphine Morphine NNP cord-005453-4057qib7 7866 2 administration administration NN cord-005453-4057qib7 7866 3 was be VBD cord-005453-4057qib7 7866 4 required require VBN cord-005453-4057qib7 7866 5 in in IN cord-005453-4057qib7 7866 6 23 23 CD cord-005453-4057qib7 7866 7 patients patient NNS cord-005453-4057qib7 7866 8 , , , cord-005453-4057qib7 7866 9 due due IN cord-005453-4057qib7 7866 10 to to IN cord-005453-4057qib7 7866 11 the the DT cord-005453-4057qib7 7866 12 occurrence occurrence NN cord-005453-4057qib7 7866 13 of of IN cord-005453-4057qib7 7866 14 non non JJ cord-005453-4057qib7 7866 15 - - JJ cord-005453-4057qib7 7866 16 oral oral JJ cord-005453-4057qib7 7866 17 complications complication NNS cord-005453-4057qib7 7866 18 . . . cord-005453-4057qib7 7867 1 Conclusions conclusion NNS cord-005453-4057qib7 7867 2 : : : cord-005453-4057qib7 7868 1 In in IN cord-005453-4057qib7 7868 2 our -PRON- PRP$ cord-005453-4057qib7 7868 3 experience experience NN cord-005453-4057qib7 7868 4 , , , cord-005453-4057qib7 7868 5 prophylaxis prophylaxis NN cord-005453-4057qib7 7868 6 with with IN cord-005453-4057qib7 7868 7 FBM FBM NNP cord-005453-4057qib7 7868 8 to to TO cord-005453-4057qib7 7868 9 prevent prevent VB cord-005453-4057qib7 7868 10 or or CC cord-005453-4057qib7 7868 11 reduce reduce VB cord-005453-4057qib7 7868 12 OM OM NNP cord-005453-4057qib7 7868 13 was be VBD cord-005453-4057qib7 7868 14 safe safe JJ cord-005453-4057qib7 7868 15 and and CC cord-005453-4057qib7 7868 16 effective effective JJ cord-005453-4057qib7 7868 17 , , , cord-005453-4057qib7 7868 18 compared compare VBN cord-005453-4057qib7 7868 19 to to IN cord-005453-4057qib7 7868 20 results result NNS cord-005453-4057qib7 7868 21 of of IN cord-005453-4057qib7 7868 22 previous previous JJ cord-005453-4057qib7 7868 23 experiences experience NNS cord-005453-4057qib7 7868 24 reported report VBN cord-005453-4057qib7 7868 25 in in IN cord-005453-4057qib7 7868 26 the the DT cord-005453-4057qib7 7868 27 literature literature NN cord-005453-4057qib7 7868 28 , , , cord-005453-4057qib7 7868 29 which which WDT cord-005453-4057qib7 7868 30 used use VBD cord-005453-4057qib7 7868 31 no no DT cord-005453-4057qib7 7868 32 prevention prevention NN cord-005453-4057qib7 7868 33 against against IN cord-005453-4057qib7 7868 34 this this DT cord-005453-4057qib7 7868 35 complication complication NN cord-005453-4057qib7 7868 36 that that WDT cord-005453-4057qib7 7868 37 negatively negatively RB cord-005453-4057qib7 7868 38 affects affect VBZ cord-005453-4057qib7 7868 39 the the DT cord-005453-4057qib7 7868 40 quality quality NN cord-005453-4057qib7 7868 41 of of IN cord-005453-4057qib7 7868 42 life life NN cord-005453-4057qib7 7868 43 of of IN cord-005453-4057qib7 7868 44 transplanted transplanted JJ cord-005453-4057qib7 7868 45 patients patient NNS cord-005453-4057qib7 7868 46 . . . cord-005453-4057qib7 7869 1 Further further JJ cord-005453-4057qib7 7869 2 studies study NNS cord-005453-4057qib7 7869 3 on on IN cord-005453-4057qib7 7869 4 a a DT cord-005453-4057qib7 7869 5 large large JJ cord-005453-4057qib7 7869 6 series series NN cord-005453-4057qib7 7869 7 of of IN cord-005453-4057qib7 7869 8 are be VBP cord-005453-4057qib7 7869 9 necessary necessary JJ cord-005453-4057qib7 7869 10 to to TO cord-005453-4057qib7 7869 11 confirm confirm VB cord-005453-4057qib7 7869 12 our -PRON- PRP$ cord-005453-4057qib7 7869 13 results result NNS cord-005453-4057qib7 7869 14 . . . cord-005453-4057qib7 7870 1 Disclosure disclosure NN cord-005453-4057qib7 7870 2 : : : cord-005453-4057qib7 7870 3 Nothing nothing NN cord-005453-4057qib7 7870 4 to to TO cord-005453-4057qib7 7870 5 declare declare VB cord-005453-4057qib7 7870 6 Background background NN cord-005453-4057qib7 7870 7 : : : cord-005453-4057qib7 7871 1 Cytogenetic cytogenetic JJ cord-005453-4057qib7 7871 2 abnormalities abnormality NNS cord-005453-4057qib7 7871 3 are be VBP cord-005453-4057qib7 7871 4 an an DT cord-005453-4057qib7 7871 5 essential essential JJ cord-005453-4057qib7 7871 6 part part NN cord-005453-4057qib7 7871 7 of of IN cord-005453-4057qib7 7871 8 prognostic prognostic JJ cord-005453-4057qib7 7871 9 systems system NNS cord-005453-4057qib7 7871 10 in in IN cord-005453-4057qib7 7871 11 myeloid myeloid JJ cord-005453-4057qib7 7871 12 malignancies malignancy NNS cord-005453-4057qib7 7871 13 before before IN cord-005453-4057qib7 7871 14 hematopoietic hematopoietic JJ cord-005453-4057qib7 7871 15 stem stem NN cord-005453-4057qib7 7871 16 cell cell NN cord-005453-4057qib7 7871 17 transplantation transplantation NN cord-005453-4057qib7 7871 18 ( ( -LRB- cord-005453-4057qib7 7871 19 HSCT HSCT NNP cord-005453-4057qib7 7871 20 ) ) -RRB- cord-005453-4057qib7 7871 21 , , , cord-005453-4057qib7 7871 22 however however RB cord-005453-4057qib7 7871 23 , , , cord-005453-4057qib7 7871 24 their -PRON- PRP$ cord-005453-4057qib7 7871 25 role role NN cord-005453-4057qib7 7871 26 in in IN cord-005453-4057qib7 7871 27 posttransplantation posttransplantation NN cord-005453-4057qib7 7871 28 prognosis prognosis NN cord-005453-4057qib7 7871 29 is be VBZ cord-005453-4057qib7 7871 30 unknown unknown JJ cord-005453-4057qib7 7871 31 . . . cord-005453-4057qib7 7872 1 The the DT cord-005453-4057qib7 7872 2 aim aim NN cord-005453-4057qib7 7872 3 of of IN cord-005453-4057qib7 7872 4 this this DT cord-005453-4057qib7 7872 5 study study NN cord-005453-4057qib7 7872 6 was be VBD cord-005453-4057qib7 7872 7 to to TO cord-005453-4057qib7 7872 8 assess assess VB cord-005453-4057qib7 7872 9 the the DT cord-005453-4057qib7 7872 10 prognostic prognostic JJ cord-005453-4057qib7 7872 11 impact impact NN cord-005453-4057qib7 7872 12 of of IN cord-005453-4057qib7 7872 13 genetic genetic JJ cord-005453-4057qib7 7872 14 risk risk NN cord-005453-4057qib7 7872 15 stratification stratification NN cord-005453-4057qib7 7872 16 of of IN cord-005453-4057qib7 7872 17 AML AML NNP cord-005453-4057qib7 7872 18 and and CC cord-005453-4057qib7 7872 19 MDS MDS NNP cord-005453-4057qib7 7872 20 patients patient NNS cord-005453-4057qib7 7872 21 on on IN cord-005453-4057qib7 7872 22 posttransplantation posttransplantation NN cord-005453-4057qib7 7872 23 course course NN cord-005453-4057qib7 7872 24 , , , cord-005453-4057qib7 7872 25 which which WDT cord-005453-4057qib7 7872 26 could could MD cord-005453-4057qib7 7872 27 be be VB cord-005453-4057qib7 7872 28 an an DT cord-005453-4057qib7 7872 29 additional additional JJ cord-005453-4057qib7 7872 30 tool tool NN cord-005453-4057qib7 7872 31 in in IN cord-005453-4057qib7 7872 32 making make VBG cord-005453-4057qib7 7872 33 decisions decision NNS cord-005453-4057qib7 7872 34 regarding regard VBG cord-005453-4057qib7 7872 35 preemptive preemptive JJ cord-005453-4057qib7 7872 36 therapy therapy NN cord-005453-4057qib7 7872 37 . . . cord-005453-4057qib7 7873 1 Methods method NNS cord-005453-4057qib7 7873 2 : : : cord-005453-4057qib7 7874 1 A a DT cord-005453-4057qib7 7874 2 retrospective retrospective JJ cord-005453-4057qib7 7874 3 analysis analysis NN cord-005453-4057qib7 7874 4 covering cover VBG cord-005453-4057qib7 7874 5 patients patient NNS cord-005453-4057qib7 7874 6 treated treat VBN cord-005453-4057qib7 7874 7 with with IN cord-005453-4057qib7 7874 8 allo allo NN cord-005453-4057qib7 7874 9 - - HYPH cord-005453-4057qib7 7874 10 HSCT HSCT NNP cord-005453-4057qib7 7874 11 between between IN cord-005453-4057qib7 7874 12 2012 2012 CD cord-005453-4057qib7 7874 13 and and CC cord-005453-4057qib7 7874 14 2018 2018 CD cord-005453-4057qib7 7874 15 . . . cord-005453-4057qib7 7875 1 Cytogenetic cytogenetic JJ cord-005453-4057qib7 7875 2 studies study NNS cord-005453-4057qib7 7875 3 included include VBD cord-005453-4057qib7 7875 4 karyotyping karyotyping NN cord-005453-4057qib7 7875 5 ( ( -LRB- cord-005453-4057qib7 7875 6 C C NNP cord-005453-4057qib7 7875 7 - - , cord-005453-4057qib7 7875 8 and and CC cord-005453-4057qib7 7875 9 Gbanding Gbanding NNP cord-005453-4057qib7 7875 10 ) ) -RRB- cord-005453-4057qib7 7875 11 and and CC cord-005453-4057qib7 7875 12 fluorescence fluorescence VB cord-005453-4057qib7 7875 13 in in IN cord-005453-4057qib7 7875 14 situ situ NN cord-005453-4057qib7 7875 15 hybridization hybridization NN cord-005453-4057qib7 7875 16 ( ( -LRB- cord-005453-4057qib7 7875 17 FISH fish NN cord-005453-4057qib7 7875 18 ) ) -RRB- cord-005453-4057qib7 7875 19 . . . cord-005453-4057qib7 7876 1 The the DT cord-005453-4057qib7 7876 2 number number NN cord-005453-4057qib7 7876 3 of of IN cord-005453-4057qib7 7876 4 analyzed analyze VBN cord-005453-4057qib7 7876 5 cells cell NNS cord-005453-4057qib7 7876 6 exceeded exceed VBD cord-005453-4057qib7 7876 7 European European NNP cord-005453-4057qib7 7876 8 Cytogenetics Cytogenetics NNP cord-005453-4057qib7 7876 9 Association Association NNP cord-005453-4057qib7 7876 10 guidelines guideline NNS cord-005453-4057qib7 7876 11 ( ( -LRB- cord-005453-4057qib7 7876 12 for for IN cord-005453-4057qib7 7876 13 each each DT cord-005453-4057qib7 7876 14 FISH fish NN cord-005453-4057qib7 7876 15 at at IN cord-005453-4057qib7 7876 16 least least RBS cord-005453-4057qib7 7876 17 600 600 CD cord-005453-4057qib7 7876 18 interphase interphase NN cord-005453-4057qib7 7876 19 nuclei nucleus NNS cord-005453-4057qib7 7876 20 were be VBD cord-005453-4057qib7 7876 21 analyzed analyze VBN cord-005453-4057qib7 7876 22 ) ) -RRB- cord-005453-4057qib7 7876 23 . . . cord-005453-4057qib7 7877 1 Cytogenetic cytogenetic JJ cord-005453-4057qib7 7877 2 risk risk NN cord-005453-4057qib7 7877 3 group group NN cord-005453-4057qib7 7877 4 in in IN cord-005453-4057qib7 7877 5 AML AML NNP cord-005453-4057qib7 7877 6 was be VBD cord-005453-4057qib7 7877 7 assessed assess VBN cord-005453-4057qib7 7877 8 based base VBN cord-005453-4057qib7 7877 9 on on IN cord-005453-4057qib7 7877 10 the the DT cord-005453-4057qib7 7877 11 ELN ELN NNP cord-005453-4057qib7 7877 12 2017 2017 CD cord-005453-4057qib7 7877 13 criteria criterion NNS cord-005453-4057qib7 7877 14 . . . cord-005453-4057qib7 7878 1 Patients patient NNS cord-005453-4057qib7 7878 2 with with IN cord-005453-4057qib7 7878 3 MDS MDS NNP cord-005453-4057qib7 7878 4 were be VBD cord-005453-4057qib7 7878 5 stratified stratify VBN cord-005453-4057qib7 7878 6 into into IN cord-005453-4057qib7 7878 7 three three CD cord-005453-4057qib7 7878 8 groups group NNS cord-005453-4057qib7 7878 9 ; ; , cord-005453-4057qib7 7878 10 favorable favorable JJ cord-005453-4057qib7 7878 11 ( ( -LRB- cord-005453-4057qib7 7878 12 good good JJ cord-005453-4057qib7 7878 13 and and CC cord-005453-4057qib7 7878 14 very very RB cord-005453-4057qib7 7878 15 good good JJ cord-005453-4057qib7 7878 16 prognostic prognostic JJ cord-005453-4057qib7 7878 17 score score NN cord-005453-4057qib7 7878 18 ) ) -RRB- cord-005453-4057qib7 7878 19 , , , cord-005453-4057qib7 7878 20 intermediate intermediate JJ cord-005453-4057qib7 7878 21 , , , cord-005453-4057qib7 7878 22 and and CC cord-005453-4057qib7 7878 23 adverse adverse JJ cord-005453-4057qib7 7878 24 ( ( -LRB- cord-005453-4057qib7 7878 25 poor poor JJ cord-005453-4057qib7 7878 26 and and CC cord-005453-4057qib7 7878 27 very very RB cord-005453-4057qib7 7878 28 poor poor JJ cord-005453-4057qib7 7878 29 ) ) -RRB- cord-005453-4057qib7 7878 30 prognostic prognostic JJ cord-005453-4057qib7 7878 31 score score NN cord-005453-4057qib7 7878 32 according accord VBG cord-005453-4057qib7 7878 33 to to IN cord-005453-4057qib7 7878 34 IPSS IPSS NNP cord-005453-4057qib7 7878 35 - - HYPH cord-005453-4057qib7 7878 36 R R NNP cord-005453-4057qib7 7878 37 2012 2012 CD cord-005453-4057qib7 7878 38 . . . cord-005453-4057qib7 7879 1 Interestingly interestingly RB cord-005453-4057qib7 7879 2 , , , cord-005453-4057qib7 7879 3 the the DT cord-005453-4057qib7 7879 4 poorest poor JJS cord-005453-4057qib7 7879 5 survival survival NN cord-005453-4057qib7 7879 6 was be VBD cord-005453-4057qib7 7879 7 in in IN cord-005453-4057qib7 7879 8 patients patient NNS cord-005453-4057qib7 7879 9 with with IN cord-005453-4057qib7 7879 10 monosomy monosomy NN cord-005453-4057qib7 7879 11 of of IN cord-005453-4057qib7 7879 12 chromosome chromosome NN cord-005453-4057qib7 7879 13 7 7 CD cord-005453-4057qib7 7879 14 , , , cord-005453-4057qib7 7879 15 which which WDT cord-005453-4057qib7 7879 16 was be VBD cord-005453-4057qib7 7879 17 present present JJ cord-005453-4057qib7 7879 18 in in IN cord-005453-4057qib7 7879 19 6 6 CD cord-005453-4057qib7 7879 20 patients patient NNS cord-005453-4057qib7 7879 21 of of IN cord-005453-4057qib7 7879 22 whom whom WP cord-005453-4057qib7 7879 23 5 5 CD cord-005453-4057qib7 7879 24 succumbed succumb VBD cord-005453-4057qib7 7879 25 to to IN cord-005453-4057qib7 7879 26 refractory refractory JJ cord-005453-4057qib7 7879 27 disease disease NN cord-005453-4057qib7 7879 28 , , , cord-005453-4057qib7 7879 29 while while IN cord-005453-4057qib7 7879 30 all all DT cord-005453-4057qib7 7879 31 patients patient NNS cord-005453-4057qib7 7879 32 who who WP cord-005453-4057qib7 7879 33 had have VBD cord-005453-4057qib7 7879 34 deletion deletion NN cord-005453-4057qib7 7879 35 of of IN cord-005453-4057qib7 7879 36 long long JJ cord-005453-4057qib7 7879 37 arm arm NN cord-005453-4057qib7 7879 38 of of IN cord-005453-4057qib7 7879 39 chromosome chromosome NN cord-005453-4057qib7 7879 40 7 7 CD cord-005453-4057qib7 7880 1 ( ( -LRB- cord-005453-4057qib7 7880 2 del del DT cord-005453-4057qib7 7880 3 7q)-are 7q)-are NNP cord-005453-4057qib7 7880 4 alive alive JJ cord-005453-4057qib7 7880 5 at at IN cord-005453-4057qib7 7880 6 the the DT cord-005453-4057qib7 7880 7 time time NN cord-005453-4057qib7 7880 8 of of IN cord-005453-4057qib7 7880 9 writing writing NN cord-005453-4057qib7 7880 10 of of IN cord-005453-4057qib7 7880 11 this this DT cord-005453-4057qib7 7880 12 report report NN cord-005453-4057qib7 7880 13 after after IN cord-005453-4057qib7 7880 14 a a DT cord-005453-4057qib7 7880 15 median median JJ cord-005453-4057qib7 7880 16 follow follow NN cord-005453-4057qib7 7880 17 - - HYPH cord-005453-4057qib7 7880 18 up up NN cord-005453-4057qib7 7880 19 of of IN cord-005453-4057qib7 7880 20 34 34 CD cord-005453-4057qib7 7880 21 months month NNS cord-005453-4057qib7 7880 22 ( ( -LRB- cord-005453-4057qib7 7880 23 21 21 CD cord-005453-4057qib7 7880 24 - - SYM cord-005453-4057qib7 7880 25 73 73 CD cord-005453-4057qib7 7880 26 ) ) -RRB- cord-005453-4057qib7 7880 27 . . . cord-005453-4057qib7 7881 1 Relapse relapse NN cord-005453-4057qib7 7881 2 was be VBD cord-005453-4057qib7 7881 3 diagnosed diagnose VBN cord-005453-4057qib7 7881 4 in in IN cord-005453-4057qib7 7881 5 31 31 CD cord-005453-4057qib7 7881 6 patients patient NNS cord-005453-4057qib7 7881 7 ( ( -LRB- cord-005453-4057qib7 7881 8 31 31 CD cord-005453-4057qib7 7881 9 % % NN cord-005453-4057qib7 7881 10 ) ) -RRB- cord-005453-4057qib7 7881 11 , , , cord-005453-4057qib7 7881 12 including include VBG cord-005453-4057qib7 7881 13 ; ; : cord-005453-4057qib7 7881 14 13 13 CD cord-005453-4057qib7 7881 15 ( ( -LRB- cord-005453-4057qib7 7881 16 42 42 CD cord-005453-4057qib7 7881 17 % % NN cord-005453-4057qib7 7881 18 ) ) -RRB- cord-005453-4057qib7 7881 19 with with IN cord-005453-4057qib7 7881 20 adverse adverse JJ cord-005453-4057qib7 7881 21 , , , cord-005453-4057qib7 7881 22 15 15 CD cord-005453-4057qib7 7881 23 ( ( -LRB- cord-005453-4057qib7 7881 24 48 48 CD cord-005453-4057qib7 7881 25 % % NN cord-005453-4057qib7 7881 26 ) ) -RRB- cord-005453-4057qib7 7881 27 with with IN cord-005453-4057qib7 7881 28 intermediate intermediate JJ cord-005453-4057qib7 7881 29 and and CC cord-005453-4057qib7 7881 30 3 3 CD cord-005453-4057qib7 7881 31 ( ( -LRB- cord-005453-4057qib7 7881 32 10 10 CD cord-005453-4057qib7 7881 33 % % NN cord-005453-4057qib7 7881 34 ) ) -RRB- cord-005453-4057qib7 7881 35 with with IN cord-005453-4057qib7 7881 36 favorable favorable JJ cord-005453-4057qib7 7881 37 cytogenetic cytogenetic JJ cord-005453-4057qib7 7881 38 risk risk NN cord-005453-4057qib7 7881 39 . . . cord-005453-4057qib7 7882 1 Among among IN cord-005453-4057qib7 7882 2 12 12 CD cord-005453-4057qib7 7882 3 patients patient NNS cord-005453-4057qib7 7882 4 with with IN cord-005453-4057qib7 7882 5 a a DT cord-005453-4057qib7 7882 6 complex complex JJ cord-005453-4057qib7 7882 7 karyotype karyotype NN cord-005453-4057qib7 7882 8 and/or and/or CC cord-005453-4057qib7 7882 9 cytogenetic cytogenetic JJ cord-005453-4057qib7 7882 10 evolution evolution NN cord-005453-4057qib7 7882 11 prior prior JJ cord-005453-4057qib7 7882 12 HCT hct NN cord-005453-4057qib7 7882 13 : : : cord-005453-4057qib7 7882 14 8 8 CD cord-005453-4057qib7 7882 15 patients patient NNS cord-005453-4057qib7 7882 16 ( ( -LRB- cord-005453-4057qib7 7882 17 67%)relapsed 67%)relapsed NNP cord-005453-4057qib7 7882 18 , , , cord-005453-4057qib7 7882 19 including include VBG cord-005453-4057qib7 7882 20 6 6 CD cord-005453-4057qib7 7882 21 ( ( -LRB- cord-005453-4057qib7 7882 22 50%)-who 50%)-who CD cord-005453-4057qib7 7882 23 died die VBD cord-005453-4057qib7 7882 24 . . . cord-005453-4057qib7 7883 1 Follow follow VB cord-005453-4057qib7 7883 2 - - HYPH cord-005453-4057qib7 7883 3 up up RP cord-005453-4057qib7 7883 4 cytogenetic cytogenetic JJ cord-005453-4057qib7 7883 5 studies study NNS cord-005453-4057qib7 7883 6 in in IN cord-005453-4057qib7 7883 7 relapse relapse NN cord-005453-4057qib7 7883 8 after after IN cord-005453-4057qib7 7883 9 transplantation transplantation NN cord-005453-4057qib7 7883 10 were be VBD cord-005453-4057qib7 7883 11 performed perform VBN cord-005453-4057qib7 7883 12 for for IN cord-005453-4057qib7 7883 13 24 24 CD cord-005453-4057qib7 7883 14 patients patient NNS cord-005453-4057qib7 7883 15 ; ; : cord-005453-4057qib7 7883 16 4 4 CD cord-005453-4057qib7 7883 17 of of IN cord-005453-4057qib7 7883 18 them -PRON- PRP cord-005453-4057qib7 7883 19 ( ( -LRB- cord-005453-4057qib7 7883 20 17 17 CD cord-005453-4057qib7 7883 21 % % NN cord-005453-4057qib7 7883 22 ) ) -RRB- cord-005453-4057qib7 7883 23 had have VBD cord-005453-4057qib7 7883 24 clonal clonal JJ cord-005453-4057qib7 7883 25 evolutions evolution NNS cord-005453-4057qib7 7883 26 of of IN cord-005453-4057qib7 7883 27 the the DT cord-005453-4057qib7 7883 28 original original JJ cord-005453-4057qib7 7883 29 karyotype karyotype NN cord-005453-4057qib7 7883 30 with with IN cord-005453-4057qib7 7883 31 additional additional JJ cord-005453-4057qib7 7883 32 abnormalities-(50 abnormalities-(50 NNS cord-005453-4057qib7 7883 33 % % NN cord-005453-4057qib7 7883 34 died die VBD cord-005453-4057qib7 7883 35 ) ) -RRB- cord-005453-4057qib7 7883 36 and and CC cord-005453-4057qib7 7883 37 7 7 CD cord-005453-4057qib7 7883 38 ( ( -LRB- cord-005453-4057qib7 7883 39 29 29 CD cord-005453-4057qib7 7883 40 % % NN cord-005453-4057qib7 7883 41 ) ) -RRB- cord-005453-4057qib7 7883 42 had have VBD cord-005453-4057qib7 7883 43 new new JJ cord-005453-4057qib7 7883 44 aberrations aberration NNS cord-005453-4057qib7 7883 45 in in IN cord-005453-4057qib7 7883 46 cells cell NNS cord-005453-4057qib7 7883 47 without without IN cord-005453-4057qib7 7883 48 primary primary JJ cord-005453-4057qib7 7883 49 changes change NNS cord-005453-4057qib7 7883 50 ( ( -LRB- cord-005453-4057qib7 7883 51 all all DT cord-005453-4057qib7 7883 52 died die VBD cord-005453-4057qib7 7883 53 ) ) -RRB- cord-005453-4057qib7 7883 54 . . . cord-005453-4057qib7 7884 1 In in IN cord-005453-4057qib7 7884 2 18 18 CD cord-005453-4057qib7 7884 3 patients patient NNS cord-005453-4057qib7 7884 4 ( ( -LRB- cord-005453-4057qib7 7884 5 18 18 CD cord-005453-4057qib7 7884 6 % % NN cord-005453-4057qib7 7884 7 ) ) -RRB- cord-005453-4057qib7 7884 8 ( ( -LRB- cord-005453-4057qib7 7884 9 8 8 CD cord-005453-4057qib7 7884 10 unfavorable unfavorable JJ cord-005453-4057qib7 7884 11 , , , cord-005453-4057qib7 7884 12 8 8 CD cord-005453-4057qib7 7884 13 intermediate intermediate JJ cord-005453-4057qib7 7884 14 group group NN cord-005453-4057qib7 7884 15 ) ) -RRB- cord-005453-4057qib7 7884 16 cytogenetic cytogenetic JJ cord-005453-4057qib7 7884 17 relapse relapse NN cord-005453-4057qib7 7884 18 was be VBD cord-005453-4057qib7 7884 19 diagnosed diagnose VBN cord-005453-4057qib7 7884 20 by by IN cord-005453-4057qib7 7884 21 FISH fish NN cord-005453-4057qib7 7884 22 analysis analysis NN cord-005453-4057qib7 7884 23 and and CC cord-005453-4057qib7 7884 24 they -PRON- PRP cord-005453-4057qib7 7884 25 were be VBD cord-005453-4057qib7 7884 26 treated treat VBN cord-005453-4057qib7 7884 27 with with IN cord-005453-4057qib7 7884 28 azacitidine azacitidine NNP cord-005453-4057qib7 7884 29 ( ( -LRB- cord-005453-4057qib7 7884 30 + + `` cord-005453-4057qib7 7884 31 /-DLI /-DLI NNS cord-005453-4057qib7 7884 32 ) ) -RRB- cord-005453-4057qib7 7884 33 achieving achieve VBG cord-005453-4057qib7 7884 34 CR CR NNP cord-005453-4057qib7 7884 35 ( ( -LRB- cord-005453-4057qib7 7884 36 N=9 N=9 NNP cord-005453-4057qib7 7884 37 , , , cord-005453-4057qib7 7884 38 50 50 CD cord-005453-4057qib7 7884 39 % % NN cord-005453-4057qib7 7884 40 ) ) -RRB- cord-005453-4057qib7 7884 41 , , , cord-005453-4057qib7 7884 42 stabilization-(N-=3 stabilization-(n-=3 NN cord-005453-4057qib7 7884 43 , , , cord-005453-4057qib7 7884 44 16 16 CD cord-005453-4057qib7 7884 45 % % NN cord-005453-4057qib7 7884 46 ) ) -RRB- cord-005453-4057qib7 7884 47 , , , cord-005453-4057qib7 7884 48 transient transient JJ cord-005453-4057qib7 7884 49 response response NN cord-005453-4057qib7 7884 50 ( ( -LRB- cord-005453-4057qib7 7884 51 N=1 N=1 NNP cord-005453-4057qib7 7884 52 ) ) -RRB- cord-005453-4057qib7 7884 53 , , , cord-005453-4057qib7 7884 54 while while IN cord-005453-4057qib7 7884 55 5 5 CD cord-005453-4057qib7 7884 56 deceased deceased JJ cord-005453-4057qib7 7884 57 ) ) -RRB- cord-005453-4057qib7 7884 58 . . . cord-005453-4057qib7 7885 1 Conclusions conclusion NNS cord-005453-4057qib7 7885 2 : : : cord-005453-4057qib7 7886 1 Cytogenetic cytogenetic JJ cord-005453-4057qib7 7886 2 studies study NNS cord-005453-4057qib7 7886 3 in in IN cord-005453-4057qib7 7886 4 patients patient NNS cord-005453-4057qib7 7886 5 after after IN cord-005453-4057qib7 7886 6 transplantation transplantation NN cord-005453-4057qib7 7886 7 may may MD cord-005453-4057qib7 7886 8 facilitate facilitate VB cord-005453-4057qib7 7886 9 assessment assessment NN cord-005453-4057qib7 7886 10 of of IN cord-005453-4057qib7 7886 11 mortality mortality NN cord-005453-4057qib7 7886 12 . . . cord-005453-4057qib7 7887 1 Karyotype Karyotype NNP cord-005453-4057qib7 7887 2 may may MD cord-005453-4057qib7 7887 3 undergo undergo VB cord-005453-4057qib7 7887 4 cytogenetic cytogenetic JJ cord-005453-4057qib7 7887 5 evolution evolution NN cord-005453-4057qib7 7887 6 after after IN cord-005453-4057qib7 7887 7 allo allo NN cord-005453-4057qib7 7887 8 - - HYPH cord-005453-4057qib7 7887 9 HSCT HSCT NNP cord-005453-4057qib7 7887 10 . . . cord-005453-4057qib7 7888 1 Patients patient NNS cord-005453-4057qib7 7888 2 with with IN cord-005453-4057qib7 7888 3 monosomy monosomy NN cord-005453-4057qib7 7888 4 of of IN cord-005453-4057qib7 7888 5 chromosome chromosome NN cord-005453-4057qib7 7888 6 7 7 CD cord-005453-4057qib7 7888 7 seem seem VBP cord-005453-4057qib7 7888 8 to to TO cord-005453-4057qib7 7888 9 have have VB cord-005453-4057qib7 7888 10 a a DT cord-005453-4057qib7 7888 11 particularly particularly RB cord-005453-4057qib7 7888 12 poor poor JJ cord-005453-4057qib7 7888 13 prognosis prognosis NN cord-005453-4057qib7 7888 14 . . . cord-005453-4057qib7 7889 1 Transplanted transplanted JJ cord-005453-4057qib7 7889 2 patients patient NNS cord-005453-4057qib7 7889 3 are be VBP cord-005453-4057qib7 7889 4 vulnerable vulnerable JJ cord-005453-4057qib7 7889 5 to to IN cord-005453-4057qib7 7889 6 new new JJ cord-005453-4057qib7 7889 7 cytogenetic cytogenetic JJ cord-005453-4057qib7 7889 8 alterations alteration NNS cord-005453-4057qib7 7889 9 . . . cord-005453-4057qib7 7890 1 Disclosure disclosure NN cord-005453-4057qib7 7890 2 : : : cord-005453-4057qib7 7890 3 Nothing nothing NN cord-005453-4057qib7 7890 4 to to TO cord-005453-4057qib7 7890 5 declare declare VB cord-005453-4057qib7 7890 6 Methods method NNS cord-005453-4057qib7 7890 7 : : : cord-005453-4057qib7 7890 8 The the DT cord-005453-4057qib7 7890 9 primary primary JJ cord-005453-4057qib7 7890 10 end end NN cord-005453-4057qib7 7890 11 - - HYPH cord-005453-4057qib7 7890 12 points point NNS cord-005453-4057qib7 7890 13 were be VBD cord-005453-4057qib7 7890 14 the the DT cord-005453-4057qib7 7890 15 rate rate NN cord-005453-4057qib7 7890 16 of of IN cord-005453-4057qib7 7890 17 Complete complete JJ cord-005453-4057qib7 7890 18 Response response NN cord-005453-4057qib7 7890 19 ( ( -LRB- cord-005453-4057qib7 7890 20 CR CR NNP cord-005453-4057qib7 7890 21 ) ) -RRB- cord-005453-4057qib7 7890 22 , , , cord-005453-4057qib7 7890 23 defined define VBN cord-005453-4057qib7 7890 24 as as IN cord-005453-4057qib7 7890 25 no no DT cord-005453-4057qib7 7890 26 emesis emesis NN cord-005453-4057qib7 7890 27 and and CC cord-005453-4057qib7 7890 28 no no DT cord-005453-4057qib7 7890 29 nausea nausea NN cord-005453-4057qib7 7890 30 without without IN cord-005453-4057qib7 7890 31 rescue rescue NN cord-005453-4057qib7 7890 32 medications medication NNS cord-005453-4057qib7 7890 33 , , , cord-005453-4057qib7 7890 34 for for IN cord-005453-4057qib7 7890 35 both both DT cord-005453-4057qib7 7890 36 acute acute JJ cord-005453-4057qib7 7890 37 ( ( -LRB- cord-005453-4057qib7 7890 38 CR-24 CR-24 NNP cord-005453-4057qib7 7890 39 ) ) -RRB- cord-005453-4057qib7 7890 40 and and CC cord-005453-4057qib7 7890 41 delayed delay VBN cord-005453-4057qib7 7890 42 ( ( -LRB- cord-005453-4057qib7 7890 43 CR CR NNP cord-005453-4057qib7 7890 44 25 25 CD cord-005453-4057qib7 7890 45 - - SYM cord-005453-4057qib7 7890 46 120 120 CD cord-005453-4057qib7 7890 47 ) ) -RRB- cord-005453-4057qib7 7890 48 CINV cinv NN cord-005453-4057qib7 7890 49 and and CC cord-005453-4057qib7 7890 50 rate rate NN cord-005453-4057qib7 7890 51 of of IN cord-005453-4057qib7 7890 52 post post JJ cord-005453-4057qib7 7890 53 - - JJ cord-005453-4057qib7 7890 54 transplant transplant JJ cord-005453-4057qib7 7890 55 complications complication NNS cord-005453-4057qib7 7890 56 until until IN cord-005453-4057qib7 7890 57 discharge discharge NN cord-005453-4057qib7 7890 58 . . . cord-005453-4057qib7 7891 1 We -PRON- PRP cord-005453-4057qib7 7891 2 prospectively prospectively RB cord-005453-4057qib7 7891 3 analyzed analyze VBD cord-005453-4057qib7 7891 4 61 61 CD cord-005453-4057qib7 7891 5 patients patient NNS cord-005453-4057qib7 7891 6 undergoing undergo VBG cord-005453-4057qib7 7891 7 Autologous autologous JJ cord-005453-4057qib7 7891 8 ( ( -LRB- cord-005453-4057qib7 7891 9 85 85 CD cord-005453-4057qib7 7891 10 % % NN cord-005453-4057qib7 7891 11 ) ) -RRB- cord-005453-4057qib7 7891 12 and and CC cord-005453-4057qib7 7891 13 Allogeneic Allogeneic NNP cord-005453-4057qib7 7891 14 ( ( -LRB- cord-005453-4057qib7 7891 15 15 15 CD cord-005453-4057qib7 7891 16 % % NN cord-005453-4057qib7 7891 17 ) ) -RRB- cord-005453-4057qib7 7891 18 Stem Stem NNP cord-005453-4057qib7 7891 19 Cell cell NN cord-005453-4057qib7 7891 20 Transplantation transplantation NN cord-005453-4057qib7 7891 21 and and CC cord-005453-4057qib7 7891 22 receiving receive VBG cord-005453-4057qib7 7891 23 CINV CINV NNP cord-005453-4057qib7 7891 24 prophylaxis prophylaxis NN cord-005453-4057qib7 7891 25 with with IN cord-005453-4057qib7 7891 26 NEPA NEPA NNP cord-005453-4057qib7 7891 27 and and CC cord-005453-4057qib7 7891 28 dexamethasone dexamethasone NN cord-005453-4057qib7 7891 29 ( ( -LRB- cord-005453-4057qib7 7891 30 schedules schedule NNS cord-005453-4057qib7 7891 31 shown show VBN cord-005453-4057qib7 7891 32 in in IN cord-005453-4057qib7 7891 33 fig.1 fig.1 NN cord-005453-4057qib7 7891 34 ) ) -RRB- cord-005453-4057qib7 7891 35 . . . cord-005453-4057qib7 7892 1 In in IN cord-005453-4057qib7 7892 2 our -PRON- PRP$ cord-005453-4057qib7 7892 3 series series NN cord-005453-4057qib7 7892 4 , , , cord-005453-4057qib7 7892 5 30 30 CD cord-005453-4057qib7 7892 6 patients patient NNS cord-005453-4057qib7 7892 7 ( ( -LRB- cord-005453-4057qib7 7892 8 49 49 CD cord-005453-4057qib7 7892 9 % % NN cord-005453-4057qib7 7892 10 ) ) -RRB- cord-005453-4057qib7 7892 11 were be VBD cord-005453-4057qib7 7892 12 female female JJ cord-005453-4057qib7 7892 13 . . . cord-005453-4057qib7 7893 1 Patients patient NNS cord-005453-4057qib7 7893 2 median median JJ cord-005453-4057qib7 7893 3 age age NN cord-005453-4057qib7 7893 4 was be VBD cord-005453-4057qib7 7893 5 55 55 CD cord-005453-4057qib7 7893 6 years year NNS cord-005453-4057qib7 7893 7 ( ( -LRB- cord-005453-4057qib7 7893 8 20 20 CD cord-005453-4057qib7 7893 9 - - SYM cord-005453-4057qib7 7893 10 74 74 CD cord-005453-4057qib7 7893 11 ) ) -RRB- cord-005453-4057qib7 7893 12 . . . cord-005453-4057qib7 7894 1 The the DT cord-005453-4057qib7 7894 2 most most RBS cord-005453-4057qib7 7894 3 frequent frequent JJ cord-005453-4057qib7 7894 4 diagnosis diagnosis NN cord-005453-4057qib7 7894 5 were be VBD cord-005453-4057qib7 7894 6 Myeloma myeloma NN cord-005453-4057qib7 7894 7 ( ( -LRB- cord-005453-4057qib7 7894 8 46 46 CD cord-005453-4057qib7 7894 9 % % NN cord-005453-4057qib7 7894 10 ) ) -RRB- cord-005453-4057qib7 7894 11 and and CC cord-005453-4057qib7 7894 12 Lymphoma Lymphoma NNP cord-005453-4057qib7 7894 13 ( ( -LRB- cord-005453-4057qib7 7894 14 39 39 CD cord-005453-4057qib7 7894 15 % % NN cord-005453-4057qib7 7894 16 ) ) -RRB- cord-005453-4057qib7 7894 17 , , , cord-005453-4057qib7 7894 18 while while IN cord-005453-4057qib7 7894 19 15 15 CD cord-005453-4057qib7 7894 20 % % NN cord-005453-4057qib7 7894 21 of of IN cord-005453-4057qib7 7894 22 patients patient NNS cord-005453-4057qib7 7894 23 were be VBD cord-005453-4057qib7 7894 24 diagnosed diagnose VBN cord-005453-4057qib7 7894 25 with with IN cord-005453-4057qib7 7894 26 AML AML NNP cord-005453-4057qib7 7894 27 or or CC cord-005453-4057qib7 7894 28 MDS MDS NNP cord-005453-4057qib7 7894 29 . . . cord-005453-4057qib7 7895 1 Myeloma myeloma NN cord-005453-4057qib7 7895 2 patients patient NNS cord-005453-4057qib7 7895 3 received receive VBD cord-005453-4057qib7 7895 4 one one CD cord-005453-4057qib7 7895 5 day day NN cord-005453-4057qib7 7895 6 HD HD NNP cord-005453-4057qib7 7895 7 - - HYPH cord-005453-4057qib7 7895 8 CT CT NNP cord-005453-4057qib7 7895 9 with with IN cord-005453-4057qib7 7895 10 Melphalan Melphalan NNP cord-005453-4057qib7 7895 11 ( ( -LRB- cord-005453-4057qib7 7895 12 75 75 CD cord-005453-4057qib7 7895 13 % % NN cord-005453-4057qib7 7895 14 Mel200/25 mel200/25 NN cord-005453-4057qib7 7895 15 % % NN cord-005453-4057qib7 7895 16 Mel140 Mel140 . cord-005453-4057qib7 7895 17 ) ) -RRB- cord-005453-4057qib7 7895 18 . . . cord-005453-4057qib7 7896 1 Lymphoma lymphoma NN cord-005453-4057qib7 7896 2 patients patient NNS cord-005453-4057qib7 7896 3 were be VBD cord-005453-4057qib7 7896 4 conditioned condition VBN cord-005453-4057qib7 7896 5 with with IN cord-005453-4057qib7 7896 6 FEAM FEAM NNP cord-005453-4057qib7 7896 7 ( ( -LRB- cord-005453-4057qib7 7896 8 87,5 87,5 CD cord-005453-4057qib7 7896 9 % % NN cord-005453-4057qib7 7896 10 ) ) -RRB- cord-005453-4057qib7 7896 11 or or CC cord-005453-4057qib7 7897 1 TT_FLU_EDX TT_FLU_EDX NNP cord-005453-4057qib7 7898 1 ( ( -LRB- cord-005453-4057qib7 7898 2 12,5 12,5 CD cord-005453-4057qib7 7898 3 % % NN cord-005453-4057qib7 7898 4 ) ) -RRB- cord-005453-4057qib7 7898 5 HD HD NNP cord-005453-4057qib7 7898 6 - - HYPH cord-005453-4057qib7 7898 7 CT CT NNP cord-005453-4057qib7 7898 8 . . . cord-005453-4057qib7 7899 1 Busulfan Busulfan NNP cord-005453-4057qib7 7899 2 - - HYPH cord-005453-4057qib7 7899 3 based base VBN cord-005453-4057qib7 7899 4 MDs MDs NNP cord-005453-4057qib7 7899 5 - - HYPH cord-005453-4057qib7 7899 6 CT CT NNP cord-005453-4057qib7 7899 7 regimen regimen NN cord-005453-4057qib7 7899 8 was be VBD cord-005453-4057qib7 7899 9 offered offer VBN cord-005453-4057qib7 7899 10 to to IN cord-005453-4057qib7 7899 11 AML AML NNP cord-005453-4057qib7 7899 12 / / SYM cord-005453-4057qib7 7899 13 MDS MDS NNP cord-005453-4057qib7 7899 14 patients patient NNS cord-005453-4057qib7 7899 15 . . . cord-005453-4057qib7 7900 1 Results result NNS cord-005453-4057qib7 7900 2 : : : cord-005453-4057qib7 7901 1 The the DT cord-005453-4057qib7 7901 2 incidence incidence NN cord-005453-4057qib7 7901 3 of of IN cord-005453-4057qib7 7901 4 CR-24 CR-24 NNP cord-005453-4057qib7 7901 5 and and CC cord-005453-4057qib7 7901 6 CR CR NNP cord-005453-4057qib7 7901 7 25 25 CD cord-005453-4057qib7 7901 8 - - SYM cord-005453-4057qib7 7901 9 120 120 CD cord-005453-4057qib7 7901 10 observed observe VBD cord-005453-4057qib7 7901 11 was be VBD cord-005453-4057qib7 7901 12 82 82 CD cord-005453-4057qib7 7901 13 % % NN cord-005453-4057qib7 7901 14 ( ( -LRB- cord-005453-4057qib7 7901 15 50/61 50/61 CD cord-005453-4057qib7 7901 16 ) ) -RRB- cord-005453-4057qib7 7901 17 and and CC cord-005453-4057qib7 7901 18 47,5 47,5 CD cord-005453-4057qib7 7901 19 % % NN cord-005453-4057qib7 7901 20 ( ( -LRB- cord-005453-4057qib7 7901 21 29/61 29/61 CD cord-005453-4057qib7 7901 22 ) ) -RRB- cord-005453-4057qib7 7901 23 , , , cord-005453-4057qib7 7901 24 respectively respectively RB cord-005453-4057qib7 7901 25 . . . cord-005453-4057qib7 7902 1 More More JJR cord-005453-4057qib7 7902 2 than than IN cord-005453-4057qib7 7902 3 grade grade NN cord-005453-4057qib7 7902 4 1 1 CD cord-005453-4057qib7 7902 5 nausea nausea NN cord-005453-4057qib7 7902 6 and and CC cord-005453-4057qib7 7902 7 vomiting vomit VBG cord-005453-4057qib7 7903 1 ( ( -LRB- cord-005453-4057qib7 7903 2 according accord VBG cord-005453-4057qib7 7903 3 to to IN cord-005453-4057qib7 7903 4 CTAE-4 CTAE-4 NNP cord-005453-4057qib7 7903 5 ) ) -RRB- cord-005453-4057qib7 7903 6 , , , cord-005453-4057qib7 7903 7 was be VBD cord-005453-4057qib7 7903 8 reported report VBN cord-005453-4057qib7 7903 9 in in IN cord-005453-4057qib7 7903 10 36 36 CD cord-005453-4057qib7 7903 11 % % NN cord-005453-4057qib7 7903 12 ( ( -LRB- cord-005453-4057qib7 7903 13 22/61 22/61 CD cord-005453-4057qib7 7903 14 ) ) -RRB- cord-005453-4057qib7 7903 15 and and CC cord-005453-4057qib7 7903 16 5 5 CD cord-005453-4057qib7 7903 17 % % NN cord-005453-4057qib7 7903 18 ( ( -LRB- cord-005453-4057qib7 7903 19 3/61 3/61 CD cord-005453-4057qib7 7903 20 ) ) -RRB- cord-005453-4057qib7 7903 21 of of IN cord-005453-4057qib7 7903 22 patients patient NNS cord-005453-4057qib7 7903 23 , , , cord-005453-4057qib7 7903 24 respectively respectively RB cord-005453-4057qib7 7903 25 . . . cord-005453-4057qib7 7904 1 Female female JJ cord-005453-4057qib7 7904 2 sex sex NN cord-005453-4057qib7 7904 3 was be VBD cord-005453-4057qib7 7904 4 associated associate VBN cord-005453-4057qib7 7904 5 with with IN cord-005453-4057qib7 7904 6 an an DT cord-005453-4057qib7 7904 7 increased increase VBN cord-005453-4057qib7 7904 8 risk risk NN cord-005453-4057qib7 7904 9 of of IN cord-005453-4057qib7 7904 10 acute acute JJ cord-005453-4057qib7 7904 11 ( ( -LRB- cord-005453-4057qib7 7904 12 HR HR NNP cord-005453-4057qib7 7904 13 19,6 19,6 CD cord-005453-4057qib7 7904 14 ; ; : cord-005453-4057qib7 7904 15 p p NN cord-005453-4057qib7 7904 16 0,037 0,037 CD cord-005453-4057qib7 7904 17 95 95 CD cord-005453-4057qib7 7904 18 % % NN cord-005453-4057qib7 7904 19 CI CI NNP cord-005453-4057qib7 7904 20 7.980 7.980 CD cord-005453-4057qib7 7904 21 - - HYPH cord-005453-4057qib7 7904 22 2.191 2.191 CD cord-005453-4057qib7 7904 23 ) ) -RRB- cord-005453-4057qib7 7904 24 but but CC cord-005453-4057qib7 7904 25 not not RB cord-005453-4057qib7 7904 26 delayed delay VBN cord-005453-4057qib7 7904 27 ( ( -LRB- cord-005453-4057qib7 7904 28 HR HR NNP cord-005453-4057qib7 7904 29 1,58 1,58 CD cord-005453-4057qib7 7904 30 ; ; : cord-005453-4057qib7 7904 31 p p NN cord-005453-4057qib7 7904 32 0,06 0,06 CD cord-005453-4057qib7 7904 33 95 95 CD cord-005453-4057qib7 7904 34 % % NN cord-005453-4057qib7 7904 35 CI CI NNP cord-005453-4057qib7 7904 36 200 200 CD cord-005453-4057qib7 7904 37 - - HYPH cord-005453-4057qib7 7904 38 2.042 2.042 CD cord-005453-4057qib7 7904 39 ) ) -RRB- cord-005453-4057qib7 7904 40 CINV CINV NNP cord-005453-4057qib7 7904 41 . . . cord-005453-4057qib7 7905 1 Similar similar JJ cord-005453-4057qib7 7905 2 rate rate NN cord-005453-4057qib7 7905 3 of of IN cord-005453-4057qib7 7905 4 CR24 CR24 NNP cord-005453-4057qib7 7905 5 and and CC cord-005453-4057qib7 7905 6 CR25 CR25 NNP cord-005453-4057qib7 7905 7 - - HYPH cord-005453-4057qib7 7905 8 120 120 NNP cord-005453-4057qib7 7905 9 was be VBD cord-005453-4057qib7 7905 10 observed observe VBN cord-005453-4057qib7 7905 11 in in IN cord-005453-4057qib7 7905 12 One one CD cord-005453-4057qib7 7905 13 - - HYPH cord-005453-4057qib7 7905 14 day day NN cord-005453-4057qib7 7905 15 HD hd NN cord-005453-4057qib7 7905 16 - - HYPH cord-005453-4057qib7 7905 17 CT CT NNP cord-005453-4057qib7 7905 18 ( ( -LRB- cord-005453-4057qib7 7905 19 82 82 CD cord-005453-4057qib7 7905 20 % % NN cord-005453-4057qib7 7905 21 and and CC cord-005453-4057qib7 7905 22 50 50 CD cord-005453-4057qib7 7905 23 % % NN cord-005453-4057qib7 7905 24 ) ) -RRB- cord-005453-4057qib7 7905 25 compared compare VBN cord-005453-4057qib7 7905 26 to to IN cord-005453-4057qib7 7905 27 MDs MDs NNP cord-005453-4057qib7 7905 28 - - HYPH cord-005453-4057qib7 7905 29 CT CT NNP cord-005453-4057qib7 7905 30 ( ( -LRB- cord-005453-4057qib7 7905 31 89 89 CD cord-005453-4057qib7 7905 32 % % NN cord-005453-4057qib7 7905 33 and and CC cord-005453-4057qib7 7905 34 42,5 42,5 CD cord-005453-4057qib7 7905 35 % % NN cord-005453-4057qib7 7905 36 ) ) -RRB- cord-005453-4057qib7 7905 37 group group NN cord-005453-4057qib7 7905 38 ( ( -LRB- cord-005453-4057qib7 7905 39 pNS pNS NNP cord-005453-4057qib7 7905 40 ) ) -RRB- cord-005453-4057qib7 7905 41 . . . cord-005453-4057qib7 7906 1 Median median JJ cord-005453-4057qib7 7906 2 lenght lenght NN cord-005453-4057qib7 7906 3 of of IN cord-005453-4057qib7 7906 4 stay stay NN cord-005453-4057qib7 7906 5 was be VBD cord-005453-4057qib7 7906 6 23 23 CD cord-005453-4057qib7 7906 7 days day NNS cord-005453-4057qib7 7906 8 ( ( -LRB- cord-005453-4057qib7 7906 9 15 15 CD cord-005453-4057qib7 7906 10 - - SYM cord-005453-4057qib7 7906 11 51 51 CD cord-005453-4057qib7 7906 12 ) ) -RRB- cord-005453-4057qib7 7906 13 . . . cord-005453-4057qib7 7907 1 No no DT cord-005453-4057qib7 7907 2 case case NN cord-005453-4057qib7 7907 3 of of IN cord-005453-4057qib7 7907 4 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 7907 5 and and CC cord-005453-4057qib7 7907 6 no no DT cord-005453-4057qib7 7907 7 exitus exitus NN cord-005453-4057qib7 7907 8 was be VBD cord-005453-4057qib7 7907 9 observed observe VBN cord-005453-4057qib7 7907 10 . . . cord-005453-4057qib7 7908 1 The the DT cord-005453-4057qib7 7908 2 incidence incidence NN cord-005453-4057qib7 7908 3 of of IN cord-005453-4057qib7 7908 4 febrile febrile JJ cord-005453-4057qib7 7908 5 neutropenia neutropenia NN cord-005453-4057qib7 7908 6 was be VBD cord-005453-4057qib7 7908 7 61 61 CD cord-005453-4057qib7 7908 8 % % NN cord-005453-4057qib7 7908 9 ( ( -LRB- cord-005453-4057qib7 7908 10 70 70 CD cord-005453-4057qib7 7908 11 % % NN cord-005453-4057qib7 7908 12 FUO fuo NN cord-005453-4057qib7 7908 13 ; ; : cord-005453-4057qib7 7908 14 22 22 CD cord-005453-4057qib7 7908 15 % % NN cord-005453-4057qib7 7908 16 sepsis sepsis NN cord-005453-4057qib7 7908 17 ; ; : cord-005453-4057qib7 7908 18 18 18 CD cord-005453-4057qib7 7908 19 % % NN cord-005453-4057qib7 7908 20 pneumonia pneumonia NN cord-005453-4057qib7 7908 21 ) ) -RRB- cord-005453-4057qib7 7908 22 . . . cord-005453-4057qib7 7909 1 Only only RB cord-005453-4057qib7 7909 2 one one CD cord-005453-4057qib7 7909 3 patient patient NN cord-005453-4057qib7 7909 4 experienced experience VBD cord-005453-4057qib7 7909 5 an an DT cord-005453-4057qib7 7909 6 aGvHD agvhd NN cord-005453-4057qib7 7909 7 on on IN cord-005453-4057qib7 7909 8 day day NN cord-005453-4057qib7 7909 9 +9 +9 CD cord-005453-4057qib7 7909 10 . . . cord-005453-4057qib7 7910 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 7910 2 ( ( -LRB- cord-005453-4057qib7 7910 3 > > NFP cord-005453-4057qib7 7910 4 1000 1000 CD cord-005453-4057qib7 7910 5 / / SYM cord-005453-4057qib7 7910 6 mcL mcl NN cord-005453-4057qib7 7910 7 ) ) -RRB- cord-005453-4057qib7 7910 8 and and CC cord-005453-4057qib7 7910 9 Platelet platelet NN cord-005453-4057qib7 7910 10 ( ( -LRB- cord-005453-4057qib7 7910 11 > > NFP cord-005453-4057qib7 7910 12 50000 50000 CD cord-005453-4057qib7 7910 13 / / SYM cord-005453-4057qib7 7910 14 mcL mcl NN cord-005453-4057qib7 7910 15 ) ) -RRB- cord-005453-4057qib7 7910 16 recovery recovery NN cord-005453-4057qib7 7910 17 occurred occur VBD cord-005453-4057qib7 7910 18 in in IN cord-005453-4057qib7 7910 19 median median NN cord-005453-4057qib7 7910 20 on on IN cord-005453-4057qib7 7910 21 day day NN cord-005453-4057qib7 7910 22 11 11 CD cord-005453-4057qib7 7910 23 ( ( -LRB- cord-005453-4057qib7 7910 24 9 9 CD cord-005453-4057qib7 7910 25 - - SYM cord-005453-4057qib7 7910 26 26 26 CD cord-005453-4057qib7 7910 27 ) ) -RRB- cord-005453-4057qib7 7910 28 and and CC cord-005453-4057qib7 7910 29 on on IN cord-005453-4057qib7 7910 30 day day NN cord-005453-4057qib7 7910 31 15 15 CD cord-005453-4057qib7 7910 32 ( ( -LRB- cord-005453-4057qib7 7910 33 4 4 CD cord-005453-4057qib7 7910 34 - - SYM cord-005453-4057qib7 7910 35 45 45 CD cord-005453-4057qib7 7910 36 ) ) -RRB- cord-005453-4057qib7 7910 37 respectively respectively RB cord-005453-4057qib7 7910 38 . . . cord-005453-4057qib7 7911 1 Conclusions conclusion NNS cord-005453-4057qib7 7911 2 : : : cord-005453-4057qib7 7912 1 NEPA NEPA NNP cord-005453-4057qib7 7912 2 seems seem VBZ cord-005453-4057qib7 7912 3 to to TO cord-005453-4057qib7 7912 4 be be VB cord-005453-4057qib7 7912 5 safe safe JJ cord-005453-4057qib7 7912 6 and and CC cord-005453-4057qib7 7912 7 effective effective JJ cord-005453-4057qib7 7912 8 in in IN cord-005453-4057qib7 7912 9 preventing prevent VBG cord-005453-4057qib7 7912 10 acute acute JJ cord-005453-4057qib7 7912 11 and and CC cord-005453-4057qib7 7912 12 delayed delay VBN cord-005453-4057qib7 7912 13 CINV CINV NNP cord-005453-4057qib7 7912 14 in in IN cord-005453-4057qib7 7912 15 patients patient NNS cord-005453-4057qib7 7912 16 receiving receive VBG cord-005453-4057qib7 7912 17 both both DT cord-005453-4057qib7 7912 18 one one CD cord-005453-4057qib7 7912 19 day day NN cord-005453-4057qib7 7912 20 HD HD NNP cord-005453-4057qib7 7912 21 - - HYPH cord-005453-4057qib7 7912 22 CT CT NNP cord-005453-4057qib7 7912 23 and and CC cord-005453-4057qib7 7912 24 MDs MDs NNP cord-005453-4057qib7 7912 25 - - HYPH cord-005453-4057qib7 7912 26 CT CT NNP cord-005453-4057qib7 7912 27 as as IN cord-005453-4057qib7 7912 28 conditioning conditioning NN cord-005453-4057qib7 7912 29 regimen regimen NN cord-005453-4057qib7 7912 30 for for IN cord-005453-4057qib7 7912 31 HSCT HSCT NNP cord-005453-4057qib7 7912 32 . . . cord-005453-4057qib7 7913 1 More More JJR cord-005453-4057qib7 7913 2 studies study NNS cord-005453-4057qib7 7913 3 are be VBP cord-005453-4057qib7 7913 4 needed need VBN cord-005453-4057qib7 7913 5 to to TO cord-005453-4057qib7 7913 6 define define VB cord-005453-4057qib7 7913 7 the the DT cord-005453-4057qib7 7913 8 better well JJR cord-005453-4057qib7 7913 9 5-HT3RA 5-ht3ra CD cord-005453-4057qib7 7913 10 and and CC cord-005453-4057qib7 7913 11 NK-1RA NK-1RA NNP cord-005453-4057qib7 7913 12 combination combination NN cord-005453-4057qib7 7913 13 and and CC cord-005453-4057qib7 7913 14 the the DT cord-005453-4057qib7 7913 15 better well JJR cord-005453-4057qib7 7913 16 schedule schedule NN cord-005453-4057qib7 7913 17 in in IN cord-005453-4057qib7 7913 18 transplant transplant NN cord-005453-4057qib7 7913 19 setting setting NN cord-005453-4057qib7 7913 20 . . . cord-005453-4057qib7 7914 1 Disclosure disclosure NN cord-005453-4057qib7 7914 2 : : : cord-005453-4057qib7 7914 3 " " `` cord-005453-4057qib7 7914 4 Nothing nothing NN cord-005453-4057qib7 7914 5 to to TO cord-005453-4057qib7 7914 6 declare declare VB cord-005453-4057qib7 7914 7 Background background NN cord-005453-4057qib7 7914 8 : : : cord-005453-4057qib7 7915 1 VOD VOD NNP cord-005453-4057qib7 7915 2 and and CC cord-005453-4057qib7 7915 3 TA TA NNP cord-005453-4057qib7 7915 4 - - HYPH cord-005453-4057qib7 7915 5 TMA TMA NNP cord-005453-4057qib7 7915 6 represent represent VBP cord-005453-4057qib7 7915 7 two two CD cord-005453-4057qib7 7915 8 early early JJ cord-005453-4057qib7 7915 9 endothelial endothelial JJ cord-005453-4057qib7 7915 10 complications complication NNS cord-005453-4057qib7 7915 11 occurring occur VBG cord-005453-4057qib7 7915 12 after after IN cord-005453-4057qib7 7915 13 allogeneic allogeneic NN cord-005453-4057qib7 7915 14 stem stem NN cord-005453-4057qib7 7915 15 cell cell NN cord-005453-4057qib7 7915 16 transplantation transplantation NN cord-005453-4057qib7 7915 17 ( ( -LRB- cord-005453-4057qib7 7915 18 SCT SCT NNP cord-005453-4057qib7 7915 19 ) ) -RRB- cord-005453-4057qib7 7915 20 sharing share VBG cord-005453-4057qib7 7915 21 many many JJ cord-005453-4057qib7 7915 22 pre pre JJ cord-005453-4057qib7 7915 23 - - JJ cord-005453-4057qib7 7915 24 transplant transplant JJ cord-005453-4057qib7 7915 25 risk risk NN cord-005453-4057qib7 7915 26 factors factor NNS cord-005453-4057qib7 7915 27 . . . cord-005453-4057qib7 7916 1 The the DT cord-005453-4057qib7 7916 2 aim aim NN cord-005453-4057qib7 7916 3 of of IN cord-005453-4057qib7 7916 4 our -PRON- PRP$ cord-005453-4057qib7 7916 5 study study NN cord-005453-4057qib7 7916 6 is be VBZ cord-005453-4057qib7 7916 7 to to TO cord-005453-4057qib7 7916 8 evaluate evaluate VB cord-005453-4057qib7 7916 9 the the DT cord-005453-4057qib7 7916 10 impact impact NN cord-005453-4057qib7 7916 11 of of IN cord-005453-4057qib7 7916 12 donor donor NN cord-005453-4057qib7 7916 13 graft graft NN cord-005453-4057qib7 7916 14 composition composition NN cord-005453-4057qib7 7916 15 , , , cord-005453-4057qib7 7916 16 engraftment engraftment NNP cord-005453-4057qib7 7916 17 kinetics kinetic NNS cord-005453-4057qib7 7916 18 and and CC cord-005453-4057qib7 7916 19 infections infection NNS cord-005453-4057qib7 7916 20 on on IN cord-005453-4057qib7 7916 21 the the DT cord-005453-4057qib7 7916 22 development development NN cord-005453-4057qib7 7916 23 of of IN cord-005453-4057qib7 7916 24 these these DT cord-005453-4057qib7 7916 25 endothelial endothelial JJ cord-005453-4057qib7 7916 26 complications complication NNS cord-005453-4057qib7 7916 27 ( ( -LRB- cord-005453-4057qib7 7916 28 EC EC NNP cord-005453-4057qib7 7916 29 ) ) -RRB- cord-005453-4057qib7 7916 30 . . . cord-005453-4057qib7 7917 1 Methods method NNS cord-005453-4057qib7 7917 2 : : : cord-005453-4057qib7 7917 3 We -PRON- PRP cord-005453-4057qib7 7917 4 retrospectively retrospectively RB cord-005453-4057qib7 7917 5 reviewed review VBD cord-005453-4057qib7 7917 6 55 55 CD cord-005453-4057qib7 7917 7 consecutive consecutive JJ cord-005453-4057qib7 7917 8 SCT SCT NNP cord-005453-4057qib7 7917 9 recipients recipient NNS cord-005453-4057qib7 7917 10 at at IN cord-005453-4057qib7 7917 11 our -PRON- PRP$ cord-005453-4057qib7 7917 12 institu institu NN cord-005453-4057qib7 7917 13 - - HYPH cord-005453-4057qib7 7917 14 tion tion NN cord-005453-4057qib7 7917 15 between between IN cord-005453-4057qib7 7917 16 January January NNP cord-005453-4057qib7 7917 17 2015 2015 CD cord-005453-4057qib7 7917 18 and and CC cord-005453-4057qib7 7917 19 June June NNP cord-005453-4057qib7 7917 20 2018 2018 CD cord-005453-4057qib7 7917 21 . . . cord-005453-4057qib7 7918 1 The the DT cord-005453-4057qib7 7918 2 median median JJ cord-005453-4057qib7 7918 3 age age NN cord-005453-4057qib7 7918 4 was be VBD cord-005453-4057qib7 7918 5 48 48 CD cord-005453-4057qib7 7918 6 years year NNS cord-005453-4057qib7 7919 1 ( ( -LRB- cord-005453-4057qib7 7919 2 range range NNP cord-005453-4057qib7 7919 3 17 17 CD cord-005453-4057qib7 7919 4 - - SYM cord-005453-4057qib7 7919 5 65 65 CD cord-005453-4057qib7 7919 6 ) ) -RRB- cord-005453-4057qib7 7919 7 . . . cord-005453-4057qib7 7920 1 Acute acute JJ cord-005453-4057qib7 7920 2 leukemia leukemia NN cord-005453-4057qib7 7920 3 was be VBD cord-005453-4057qib7 7920 4 diagnosed diagnose VBN cord-005453-4057qib7 7920 5 in in IN cord-005453-4057qib7 7920 6 33 33 CD cord-005453-4057qib7 7920 7 patients patient NNS cord-005453-4057qib7 7920 8 ( ( -LRB- cord-005453-4057qib7 7920 9 60 60 CD cord-005453-4057qib7 7920 10 % % NN cord-005453-4057qib7 7920 11 ) ) -RRB- cord-005453-4057qib7 7920 12 . . . cord-005453-4057qib7 7921 1 Complete complete JJ cord-005453-4057qib7 7921 2 remission remission NN cord-005453-4057qib7 7921 3 was be VBD cord-005453-4057qib7 7921 4 documented document VBN cord-005453-4057qib7 7921 5 in in IN cord-005453-4057qib7 7921 6 63 63 CD cord-005453-4057qib7 7921 7 % % NN cord-005453-4057qib7 7921 8 of of IN cord-005453-4057qib7 7921 9 patients patient NNS cord-005453-4057qib7 7921 10 at at IN cord-005453-4057qib7 7921 11 transplant transplant NN cord-005453-4057qib7 7921 12 . . . cord-005453-4057qib7 7922 1 Donor donor NN cord-005453-4057qib7 7922 2 source source NN cord-005453-4057qib7 7922 3 was be VBD cord-005453-4057qib7 7922 4 from from IN cord-005453-4057qib7 7922 5 HLA HLA NNP cord-005453-4057qib7 7922 6 mismatched mismatched JJ cord-005453-4057qib7 7922 7 donor donor NN cord-005453-4057qib7 7922 8 in in IN cord-005453-4057qib7 7922 9 53 53 CD cord-005453-4057qib7 7922 10 % % NN cord-005453-4057qib7 7922 11 and and CC cord-005453-4057qib7 7922 12 from from IN cord-005453-4057qib7 7922 13 unrelated unrelated JJ cord-005453-4057qib7 7922 14 donor donor NN cord-005453-4057qib7 7922 15 in in IN cord-005453-4057qib7 7922 16 56 56 CD cord-005453-4057qib7 7922 17 % % NN cord-005453-4057qib7 7922 18 of of IN cord-005453-4057qib7 7922 19 the the DT cord-005453-4057qib7 7922 20 patients patient NNS cord-005453-4057qib7 7922 21 . . . cord-005453-4057qib7 7923 1 HBV HBV NNP cord-005453-4057qib7 7923 2 positive positive JJ cord-005453-4057qib7 7923 3 patients patient NNS cord-005453-4057qib7 7923 4 were be VBD cord-005453-4057qib7 7923 5 13 13 CD cord-005453-4057qib7 7923 6 % % NN cord-005453-4057qib7 7923 7 of of IN cord-005453-4057qib7 7923 8 the the DT cord-005453-4057qib7 7923 9 sample sample NN cord-005453-4057qib7 7923 10 . . . cord-005453-4057qib7 7924 1 Conditioning conditioning NN cord-005453-4057qib7 7924 2 regimen regimen NN cord-005453-4057qib7 7924 3 was be VBD cord-005453-4057qib7 7924 4 busulfan busulfan NN cord-005453-4057qib7 7924 5 based base VBN cord-005453-4057qib7 7924 6 in in IN cord-005453-4057qib7 7924 7 63 63 CD cord-005453-4057qib7 7924 8 % % NN cord-005453-4057qib7 7924 9 of of IN cord-005453-4057qib7 7924 10 patients patient NNS cord-005453-4057qib7 7924 11 . . . cord-005453-4057qib7 7925 1 Ursodeoxycholic ursodeoxycholic JJ cord-005453-4057qib7 7925 2 acid acid NN cord-005453-4057qib7 7925 3 and and CC cord-005453-4057qib7 7925 4 unfractionated unfractionated JJ cord-005453-4057qib7 7925 5 heparin heparin NN cord-005453-4057qib7 7925 6 were be VBD cord-005453-4057qib7 7925 7 given give VBN cord-005453-4057qib7 7925 8 to to IN cord-005453-4057qib7 7925 9 all all DT cord-005453-4057qib7 7925 10 patients patient NNS cord-005453-4057qib7 7925 11 as as IN cord-005453-4057qib7 7925 12 VOD VOD NNP cord-005453-4057qib7 7925 13 prophylaxis prophylaxis NN cord-005453-4057qib7 7925 14 . . . cord-005453-4057qib7 7926 1 Cyclosporine cyclosporine NN cord-005453-4057qib7 7926 2 was be VBD cord-005453-4057qib7 7926 3 used use VBN cord-005453-4057qib7 7926 4 as as IN cord-005453-4057qib7 7926 5 GvHD GvHD NNP cord-005453-4057qib7 7926 6 prophylaxis prophylaxis NN cord-005453-4057qib7 7926 7 . . . cord-005453-4057qib7 7927 1 lymphocytic lymphocytic NNP cord-005453-4057qib7 7927 2 subpopulation subpopulation NNP cord-005453-4057qib7 7927 3 analysis analysis NN cord-005453-4057qib7 7927 4 ( ( -LRB- cord-005453-4057qib7 7927 5 CD3 CD3 NNP cord-005453-4057qib7 7927 6 + + CC cord-005453-4057qib7 7927 7 , , , cord-005453-4057qib7 7927 8 CD4 CD4 NNP cord-005453-4057qib7 7927 9 + + CC cord-005453-4057qib7 7927 10 , , , cord-005453-4057qib7 7927 11 CD8 CD8 NNP cord-005453-4057qib7 7927 12 + + CC cord-005453-4057qib7 7928 1 and and CC cord-005453-4057qib7 7928 2 CD16+/CD56 cd16+/cd56 NN cord-005453-4057qib7 7929 1 + + LS cord-005453-4057qib7 7929 2 ) ) -RRB- cord-005453-4057qib7 7929 3 and and CC cord-005453-4057qib7 7929 4 CD34 CD34 NNP cord-005453-4057qib7 7929 5 + + CC cord-005453-4057qib7 7929 6 cells cell NNS cord-005453-4057qib7 7929 7 count count VBP cord-005453-4057qib7 7929 8 on on IN cord-005453-4057qib7 7929 9 the the DT cord-005453-4057qib7 7929 10 donor donor NN cord-005453-4057qib7 7929 11 graft graft NN cord-005453-4057qib7 7929 12 were be VBD cord-005453-4057qib7 7929 13 performed perform VBN cord-005453-4057qib7 7929 14 using use VBG cord-005453-4057qib7 7929 15 BD BD NNP cord-005453-4057qib7 7929 16 Facs Facs NNP cord-005453-4057qib7 7929 17 Cantoll Cantoll NNP cord-005453-4057qib7 7929 18 . . . cord-005453-4057qib7 7930 1 All all DT cord-005453-4057qib7 7930 2 patients patient NNS cord-005453-4057qib7 7930 3 had have VBD cord-005453-4057qib7 7930 4 routine routine JJ cord-005453-4057qib7 7930 5 monitoring monitoring NN cord-005453-4057qib7 7930 6 for for IN cord-005453-4057qib7 7930 7 EBV EBV NNP cord-005453-4057qib7 7930 8 and and CC cord-005453-4057qib7 7930 9 CMV CMV NNP cord-005453-4057qib7 7930 10 PCR PCR NNP cord-005453-4057qib7 7930 11 , , , cord-005453-4057qib7 7930 12 hemolysis hemolysis NN cord-005453-4057qib7 7930 13 tests test NNS cord-005453-4057qib7 7930 14 , , , cord-005453-4057qib7 7930 15 creatinine creatinine NN cord-005453-4057qib7 7930 16 and and CC cord-005453-4057qib7 7930 17 electrolyte electrolyte JJ cord-005453-4057qib7 7930 18 panels panel NNS cord-005453-4057qib7 7930 19 , , , cord-005453-4057qib7 7930 20 proteinuria proteinuria NN cord-005453-4057qib7 7930 21 , , , cord-005453-4057qib7 7930 22 complete complete JJ cord-005453-4057qib7 7930 23 blood blood NN cord-005453-4057qib7 7930 24 count count NN cord-005453-4057qib7 7930 25 , , , cord-005453-4057qib7 7930 26 blood blood NN cord-005453-4057qib7 7930 27 pressure pressure NN cord-005453-4057qib7 7930 28 and and CC cord-005453-4057qib7 7930 29 Schistocytes Schistocytes NNPS cord-005453-4057qib7 7930 30 by by IN cord-005453-4057qib7 7930 31 direct direct JJ cord-005453-4057qib7 7930 32 examination examination NN cord-005453-4057qib7 7930 33 until until IN cord-005453-4057qib7 7930 34 day day NN cord-005453-4057qib7 7930 35 +100 +100 NNS cord-005453-4057qib7 7930 36 . . . cord-005453-4057qib7 7931 1 The the DT cord-005453-4057qib7 7931 2 Fisher Fisher NNP cord-005453-4057qib7 7931 3 's 's POS cord-005453-4057qib7 7931 4 exact exact JJ cord-005453-4057qib7 7931 5 test test NN cord-005453-4057qib7 7931 6 was be VBD cord-005453-4057qib7 7931 7 used use VBN cord-005453-4057qib7 7931 8 to to TO cord-005453-4057qib7 7931 9 compare compare VB cord-005453-4057qib7 7931 10 categorical categorical JJ cord-005453-4057qib7 7931 11 variables variable NNS cord-005453-4057qib7 7931 12 , , , cord-005453-4057qib7 7931 13 while while IN cord-005453-4057qib7 7931 14 continuous continuous JJ cord-005453-4057qib7 7931 15 variables variable NNS cord-005453-4057qib7 7931 16 were be VBD cord-005453-4057qib7 7931 17 analyzed analyze VBN cord-005453-4057qib7 7931 18 with with IN cord-005453-4057qib7 7931 19 Anova Anova NNP cord-005453-4057qib7 7931 20 test test NN cord-005453-4057qib7 7931 21 . . . cord-005453-4057qib7 7932 1 Diagnosis diagnosis NN cord-005453-4057qib7 7932 2 of of IN cord-005453-4057qib7 7932 3 VOD VOD NNP cord-005453-4057qib7 7932 4 and and CC cord-005453-4057qib7 7932 5 TA TA NNP cord-005453-4057qib7 7932 6 - - HYPH cord-005453-4057qib7 7932 7 TMA TMA NNP cord-005453-4057qib7 7932 8 were be VBD cord-005453-4057qib7 7932 9 carried carry VBN cord-005453-4057qib7 7932 10 out out RP cord-005453-4057qib7 7932 11 by by IN cord-005453-4057qib7 7932 12 using use VBG cord-005453-4057qib7 7932 13 EBMT EBMT NNP cord-005453-4057qib7 7932 14 and and CC cord-005453-4057qib7 7932 15 Cho Cho NNP cord-005453-4057qib7 7932 16 criteria criterion NNS cord-005453-4057qib7 7932 17 respectively respectively RB cord-005453-4057qib7 7932 18 . . . cord-005453-4057qib7 7933 1 Results result NNS cord-005453-4057qib7 7933 2 : : : cord-005453-4057qib7 7934 1 The the DT cord-005453-4057qib7 7934 2 incidence incidence NN cord-005453-4057qib7 7934 3 of of IN cord-005453-4057qib7 7934 4 very very RB cord-005453-4057qib7 7934 5 severe severe JJ cord-005453-4057qib7 7934 6 VOD vod NN cord-005453-4057qib7 7934 7 and and CC cord-005453-4057qib7 7934 8 TMA TMA NNP cord-005453-4057qib7 7934 9 was be VBD cord-005453-4057qib7 7934 10 13 13 CD cord-005453-4057qib7 7934 11 % % NN cord-005453-4057qib7 7934 12 ( ( -LRB- cord-005453-4057qib7 7934 13 7/55 7/55 CD cord-005453-4057qib7 7934 14 ) ) -RRB- cord-005453-4057qib7 7934 15 and and CC cord-005453-4057qib7 7934 16 14,5 14,5 CD cord-005453-4057qib7 7934 17 % % NN cord-005453-4057qib7 7934 18 ( ( -LRB- cord-005453-4057qib7 7934 19 8/55 8/55 CD cord-005453-4057qib7 7934 20 ) ) -RRB- cord-005453-4057qib7 7934 21 respectively respectively RB cord-005453-4057qib7 7934 22 . . . cord-005453-4057qib7 7935 1 CMV CMV NNP cord-005453-4057qib7 7935 2 reactivations reactivation NNS cord-005453-4057qib7 7935 3 with with IN cord-005453-4057qib7 7935 4 viral viral JJ cord-005453-4057qib7 7935 5 load load NN cord-005453-4057qib7 7935 6 over over IN cord-005453-4057qib7 7935 7 30.000 30.000 CD cord-005453-4057qib7 7935 8 cv/ cv/ NNP cord-005453-4057qib7 7935 9 ml ml NN cord-005453-4057qib7 7935 10 was be VBD cord-005453-4057qib7 7935 11 27 27 CD cord-005453-4057qib7 7935 12 % % NN cord-005453-4057qib7 7935 13 and and CC cord-005453-4057qib7 7935 14 5 5 CD cord-005453-4057qib7 7935 15 % % NN cord-005453-4057qib7 7935 16 in in IN cord-005453-4057qib7 7935 17 patients patient NNS cord-005453-4057qib7 7935 18 with with IN cord-005453-4057qib7 7935 19 and and CC cord-005453-4057qib7 7935 20 without without IN cord-005453-4057qib7 7935 21 EC EC NNP cord-005453-4057qib7 7935 22 , , , cord-005453-4057qib7 7935 23 respectively respectively RB cord-005453-4057qib7 7935 24 ( ( -LRB- cord-005453-4057qib7 7935 25 p p NN cord-005453-4057qib7 7935 26 0,041 0,041 CD cord-005453-4057qib7 7935 27 ; ; . cord-005453-4057qib7 7936 1 HR HR NNP cord-005453-4057qib7 7936 2 2,97 2,97 CD cord-005453-4057qib7 7936 3 p0,0055 p0,0055 NNP cord-005453-4057qib7 7937 1 95%CI 95%ci CD cord-005453-4057qib7 7937 2 1,38 1,38 CD cord-005453-4057qib7 7937 3 - - HYPH cord-005453-4057qib7 7937 4 6,4 6,4 CD cord-005453-4057qib7 7937 5 ) ) -RRB- cord-005453-4057qib7 7937 6 . . . cord-005453-4057qib7 7938 1 The the DT cord-005453-4057qib7 7938 2 median median JJ cord-005453-4057qib7 7938 3 day day NN cord-005453-4057qib7 7938 4 to to IN cord-005453-4057qib7 7938 5 neutrophils neutrophil NNS cord-005453-4057qib7 7938 6 ( ( -LRB- cord-005453-4057qib7 7938 7 Ns Ns NNP cord-005453-4057qib7 7938 8 ) ) -RRB- cord-005453-4057qib7 7938 9 engraftment engraftment NNP cord-005453-4057qib7 7938 10 ( ( -LRB- cord-005453-4057qib7 7938 11 500 500 CD cord-005453-4057qib7 7938 12 / / SYM cord-005453-4057qib7 7938 13 ml ml NN cord-005453-4057qib7 7938 14 and and CC cord-005453-4057qib7 7938 15 1000 1000 CD cord-005453-4057qib7 7938 16 / / SYM cord-005453-4057qib7 7938 17 ml ml NN cord-005453-4057qib7 7938 18 ) ) -RRB- cord-005453-4057qib7 7938 19 was be VBD cord-005453-4057qib7 7938 20 14 14 CD cord-005453-4057qib7 7938 21 vs vs IN cord-005453-4057qib7 7938 22 17 17 CD cord-005453-4057qib7 7938 23 and and CC cord-005453-4057qib7 7938 24 14,5 14,5 CD cord-005453-4057qib7 7938 25 vs vs IN cord-005453-4057qib7 7938 26 18 18 CD cord-005453-4057qib7 7938 27 in in IN cord-005453-4057qib7 7938 28 VOD VOD NNP cord-005453-4057qib7 7938 29 / / SYM cord-005453-4057qib7 7938 30 TMA TMA NNP cord-005453-4057qib7 7938 31 group group NN cord-005453-4057qib7 7938 32 vs vs IN cord-005453-4057qib7 7938 33 control control NNP cord-005453-4057qib7 7938 34 group group NNP cord-005453-4057qib7 7938 35 ( ( -LRB- cord-005453-4057qib7 7938 36 p0,03 p0,03 NNP cord-005453-4057qib7 7938 37 and and CC cord-005453-4057qib7 7938 38 0,027 0,027 CD cord-005453-4057qib7 7938 39 , , , cord-005453-4057qib7 7938 40 respectively respectively RB cord-005453-4057qib7 7938 41 ) ) -RRB- cord-005453-4057qib7 7938 42 . . . cord-005453-4057qib7 7939 1 More more RBR cord-005453-4057qib7 7939 2 rapid rapid JJ cord-005453-4057qib7 7939 3 neutrophils neutrophil NNS cord-005453-4057qib7 7939 4 engraftment engraftment NN cord-005453-4057qib7 7939 5 ( ( -LRB- cord-005453-4057qib7 7940 1 Ns Ns NNP cord-005453-4057qib7 7940 2 > > XX cord-005453-4057qib7 7941 1 500 500 CD cord-005453-4057qib7 7941 2 / / SYM cord-005453-4057qib7 7941 3 ml ml NN cord-005453-4057qib7 7941 4 and and CC cord-005453-4057qib7 7941 5 Ns>1000 Ns>1000 NNP cord-005453-4057qib7 7941 6 / / SYM cord-005453-4057qib7 7941 7 ml ml NN cord-005453-4057qib7 7942 1 within within IN cord-005453-4057qib7 7942 2 13 13 CD cord-005453-4057qib7 7942 3 days day NNS cord-005453-4057qib7 7942 4 ) ) -RRB- cord-005453-4057qib7 7942 5 was be VBD cord-005453-4057qib7 7942 6 related relate VBN cord-005453-4057qib7 7942 7 to to IN cord-005453-4057qib7 7942 8 a a DT cord-005453-4057qib7 7942 9 higher high JJR cord-005453-4057qib7 7942 10 risk risk NN cord-005453-4057qib7 7942 11 of of IN cord-005453-4057qib7 7942 12 EC EC NNP cord-005453-4057qib7 7942 13 with with IN cord-005453-4057qib7 7942 14 a a DT cord-005453-4057qib7 7942 15 HR hr NN cord-005453-4057qib7 7942 16 of of IN cord-005453-4057qib7 7942 17 2,67 2,67 CD cord-005453-4057qib7 7943 1 ( ( -LRB- cord-005453-4057qib7 7943 2 p p NN cord-005453-4057qib7 7943 3 0,015 0,015 CD cord-005453-4057qib7 7943 4 ; ; : cord-005453-4057qib7 7943 5 95%CI 95%ci CD cord-005453-4057qib7 7943 6 1,2 1,2 CD cord-005453-4057qib7 7943 7 - - SYM cord-005453-4057qib7 7943 8 5,9 5,9 CD cord-005453-4057qib7 7943 9 ) ) -RRB- cord-005453-4057qib7 7943 10 and and CC cord-005453-4057qib7 7943 11 2,94 2,94 CD cord-005453-4057qib7 7944 1 ( ( -LRB- cord-005453-4057qib7 7944 2 p p NN cord-005453-4057qib7 7944 3 0,006 0,006 CD cord-005453-4057qib7 7944 4 ; ; : cord-005453-4057qib7 7944 5 95 95 CD cord-005453-4057qib7 7944 6 % % NN cord-005453-4057qib7 7944 7 CI CI NNP cord-005453-4057qib7 7944 8 1,4 1,4 CD cord-005453-4057qib7 7944 9 - - HYPH cord-005453-4057qib7 7944 10 6,3 6,3 CD cord-005453-4057qib7 7944 11 ) ) -RRB- cord-005453-4057qib7 7944 12 . . . cord-005453-4057qib7 7945 1 Patients patient NNS cord-005453-4057qib7 7945 2 with with IN cord-005453-4057qib7 7945 3 EC EC NNP cord-005453-4057qib7 7945 4 received receive VBD cord-005453-4057qib7 7945 5 a a DT cord-005453-4057qib7 7945 6 donor donor NN cord-005453-4057qib7 7945 7 graft graft NN cord-005453-4057qib7 7945 8 with with IN cord-005453-4057qib7 7945 9 a a DT cord-005453-4057qib7 7945 10 higher high JJR cord-005453-4057qib7 7945 11 median median JJ cord-005453-4057qib7 7945 12 numbers number NNS cord-005453-4057qib7 7945 13 ( ( -LRB- cord-005453-4057qib7 7945 14 x10e6 x10e6 NNP cord-005453-4057qib7 7945 15 / / SYM cord-005453-4057qib7 7945 16 Kg Kg NNP cord-005453-4057qib7 7945 17 ) ) -RRB- cord-005453-4057qib7 7945 18 of of IN cord-005453-4057qib7 7945 19 CD3 CD3 NNP cord-005453-4057qib7 7945 20 + + CC cord-005453-4057qib7 7946 1 and and CC cord-005453-4057qib7 7946 2 CD8 CD8 NNP cord-005453-4057qib7 7946 3 + + CC cord-005453-4057qib7 7946 4 ( ( -LRB- cord-005453-4057qib7 7946 5 p>0,05 p>0,05 NNP cord-005453-4057qib7 7946 6 ) ) -RRB- cord-005453-4057qib7 7946 7 and and CC cord-005453-4057qib7 7946 8 a a DT cord-005453-4057qib7 7946 9 lower low JJR cord-005453-4057qib7 7946 10 numbers number NNS cord-005453-4057qib7 7946 11 ( ( -LRB- cord-005453-4057qib7 7946 12 x10e6 x10e6 NNP cord-005453-4057qib7 7946 13 / / SYM cord-005453-4057qib7 7946 14 Kg Kg NNP cord-005453-4057qib7 7946 15 ) ) -RRB- cord-005453-4057qib7 7946 16 of of IN cord-005453-4057qib7 7946 17 NK NK NNP cord-005453-4057qib7 7946 18 cells cell NNS cord-005453-4057qib7 7946 19 ( ( -LRB- cord-005453-4057qib7 7946 20 p>0,05 p>0,05 NNP cord-005453-4057qib7 7946 21 ) ) -RRB- cord-005453-4057qib7 7946 22 . . . cord-005453-4057qib7 7947 1 Patients patient NNS cord-005453-4057qib7 7947 2 who who WP cord-005453-4057qib7 7947 3 received receive VBD cord-005453-4057qib7 7947 4 a a DT cord-005453-4057qib7 7947 5 CD8 CD8 NNP cord-005453-4057qib7 7947 6 + + SYM cord-005453-4057qib7 7947 7 cells cell NNS cord-005453-4057qib7 7947 8 count count VBP cord-005453-4057qib7 7948 1 > > XX cord-005453-4057qib7 7948 2 12x10e6 12x10e6 CD cord-005453-4057qib7 7948 3 / / SYM cord-005453-4057qib7 7948 4 Kg Kg NNP cord-005453-4057qib7 7948 5 and and CC cord-005453-4057qib7 7948 6 NK NK NNP cord-005453-4057qib7 7948 7 cells cell NNS cord-005453-4057qib7 7948 8 count count VBP cord-005453-4057qib7 7949 1 < < XX cord-005453-4057qib7 7949 2 2,5x10e6 2,5x10e6 CD cord-005453-4057qib7 7949 3 / / SYM cord-005453-4057qib7 7949 4 Kg Kg NNP cord-005453-4057qib7 7949 5 presented present VBD cord-005453-4057qib7 7949 6 a a DT cord-005453-4057qib7 7949 7 Relative Relative NNP cord-005453-4057qib7 7949 8 Risk risk NN cord-005453-4057qib7 7949 9 of of IN cord-005453-4057qib7 7949 10 EC EC NNP cord-005453-4057qib7 7949 11 of of IN cord-005453-4057qib7 7949 12 2,37 2,37 CD cord-005453-4057qib7 7950 1 ( ( -LRB- cord-005453-4057qib7 7950 2 p p NN cord-005453-4057qib7 7950 3 0,036 0,036 CD cord-005453-4057qib7 7950 4 ; ; : cord-005453-4057qib7 7950 5 95 95 CD cord-005453-4057qib7 7950 6 % % NN cord-005453-4057qib7 7950 7 CI CI NNP cord-005453-4057qib7 7950 8 1,06 1,06 CD cord-005453-4057qib7 7950 9 - - HYPH cord-005453-4057qib7 7950 10 5,3 5,3 CD cord-005453-4057qib7 7950 11 ) ) -RRB- cord-005453-4057qib7 7950 12 and and CC cord-005453-4057qib7 7950 13 2,35 2,35 CD cord-005453-4057qib7 7950 14 ( ( -LRB- cord-005453-4057qib7 7950 15 p p NN cord-005453-4057qib7 7950 16 0,004 0,004 CD cord-005453-4057qib7 7950 17 ; ; : cord-005453-4057qib7 7950 18 95 95 CD cord-005453-4057qib7 7950 19 % % NN cord-005453-4057qib7 7950 20 CI CI NNP cord-005453-4057qib7 7950 21 1,02 1,02 CD cord-005453-4057qib7 7950 22 - - HYPH cord-005453-4057qib7 7950 23 5,4 5,4 CD cord-005453-4057qib7 7950 24 ) ) -RRB- cord-005453-4057qib7 7950 25 , , , cord-005453-4057qib7 7950 26 respectively respectively RB cord-005453-4057qib7 7950 27 . . . cord-005453-4057qib7 7951 1 There there EX cord-005453-4057qib7 7951 2 were be VBD cord-005453-4057qib7 7951 3 no no DT cord-005453-4057qib7 7951 4 differences difference NNS cord-005453-4057qib7 7951 5 with with IN cord-005453-4057qib7 7951 6 respect respect NN cord-005453-4057qib7 7951 7 to to IN cord-005453-4057qib7 7951 8 the the DT cord-005453-4057qib7 7951 9 other other JJ cord-005453-4057qib7 7951 10 analyzed analyze VBN cord-005453-4057qib7 7951 11 variables variable NNS cord-005453-4057qib7 7951 12 between between IN cord-005453-4057qib7 7951 13 patients patient NNS cord-005453-4057qib7 7951 14 who who WP cord-005453-4057qib7 7951 15 developed develop VBD cord-005453-4057qib7 7951 16 VOD VOD NNP cord-005453-4057qib7 7951 17 / / SYM cord-005453-4057qib7 7951 18 TMA TMA NNP cord-005453-4057qib7 7951 19 compared compare VBN cord-005453-4057qib7 7951 20 with with IN cord-005453-4057qib7 7951 21 those those DT cord-005453-4057qib7 7951 22 who who WP cord-005453-4057qib7 7951 23 did do VBD cord-005453-4057qib7 7951 24 not not RB cord-005453-4057qib7 7951 25 . . . cord-005453-4057qib7 7952 1 ( ( -LRB- cord-005453-4057qib7 7952 2 Pic_01 Pic_01 NNP cord-005453-4057qib7 7952 3 ) ) -RRB- cord-005453-4057qib7 7952 4 Conclusions conclusion NNS cord-005453-4057qib7 7952 5 : : : cord-005453-4057qib7 7952 6 CMV CMV NNP cord-005453-4057qib7 7952 7 viremia viremia NN cord-005453-4057qib7 7952 8 , , , cord-005453-4057qib7 7952 9 early early JJ cord-005453-4057qib7 7952 10 neutrophils neutrophil NNS cord-005453-4057qib7 7952 11 engraftment engraftment NN cord-005453-4057qib7 7952 12 and and CC cord-005453-4057qib7 7952 13 donor donor NN cord-005453-4057qib7 7952 14 NK NK NNP cord-005453-4057qib7 7952 15 and and CC cord-005453-4057qib7 7952 16 CD8 CD8 NNP cord-005453-4057qib7 7953 1 + + CC cord-005453-4057qib7 7953 2 cells cell NNS cord-005453-4057qib7 7953 3 infused infuse VBN cord-005453-4057qib7 7953 4 are be VBP cord-005453-4057qib7 7953 5 associated associate VBN cord-005453-4057qib7 7953 6 with with IN cord-005453-4057qib7 7953 7 the the DT cord-005453-4057qib7 7953 8 risk risk NN cord-005453-4057qib7 7953 9 of of IN cord-005453-4057qib7 7953 10 VOD VOD NNP cord-005453-4057qib7 7953 11 and and CC cord-005453-4057qib7 7953 12 TMA TMA NNP cord-005453-4057qib7 7953 13 . . . cord-005453-4057qib7 7954 1 Very very RB cord-005453-4057qib7 7954 2 few few JJ cord-005453-4057qib7 7954 3 studies study NNS cord-005453-4057qib7 7954 4 evaluated evaluate VBD cord-005453-4057qib7 7954 5 the the DT cord-005453-4057qib7 7954 6 link link NN cord-005453-4057qib7 7954 7 between between IN cord-005453-4057qib7 7954 8 these these DT cord-005453-4057qib7 7954 9 variables variable NNS cord-005453-4057qib7 7954 10 and and CC cord-005453-4057qib7 7954 11 the the DT cord-005453-4057qib7 7954 12 risk risk NN cord-005453-4057qib7 7954 13 of of IN cord-005453-4057qib7 7954 14 developing develop VBG cord-005453-4057qib7 7954 15 such such JJ cord-005453-4057qib7 7954 16 two two CD cord-005453-4057qib7 7954 17 complications complication NNS cord-005453-4057qib7 7954 18 . . . cord-005453-4057qib7 7955 1 It -PRON- PRP cord-005453-4057qib7 7955 2 could could MD cord-005453-4057qib7 7955 3 be be VB cord-005453-4057qib7 7955 4 interesting interesting JJ cord-005453-4057qib7 7955 5 to to TO cord-005453-4057qib7 7955 6 investigate investigate VB cord-005453-4057qib7 7955 7 these these DT cord-005453-4057qib7 7955 8 relationships relationship NNS cord-005453-4057qib7 7955 9 on on IN cord-005453-4057qib7 7955 10 larger large JJR cord-005453-4057qib7 7955 11 series series NN cord-005453-4057qib7 7955 12 . . . cord-005453-4057qib7 7956 1 Clinical clinical JJ cord-005453-4057qib7 7956 2 Trial Trial NNP cord-005453-4057qib7 7956 3 Registry Registry NNP cord-005453-4057qib7 7956 4 : : : cord-005453-4057qib7 7957 1 Not not RB cord-005453-4057qib7 7957 2 applicable applicable JJ cord-005453-4057qib7 7957 3 Disclosure disclosure NN cord-005453-4057qib7 7957 4 : : : cord-005453-4057qib7 7957 5 Nothing nothing NN cord-005453-4057qib7 7957 6 to to TO cord-005453-4057qib7 7957 7 declare declare VB cord-005453-4057qib7 7957 8 P358 P358 NNS cord-005453-4057qib7 7958 1 When when WRB cord-005453-4057qib7 7958 2 the the DT cord-005453-4057qib7 7958 3 last last JJ cord-005453-4057qib7 7958 4 hope hope NN cord-005453-4057qib7 7958 5 turns turn VBZ cord-005453-4057qib7 7958 6 out out RP cord-005453-4057qib7 7958 7 to to TO cord-005453-4057qib7 7958 8 be be VB cord-005453-4057qib7 7958 9 just just RB cord-005453-4057qib7 7958 10 as as RB cord-005453-4057qib7 7958 11 good good JJ cord-005453-4057qib7 7958 12 as as IN cord-005453-4057qib7 7958 13 best best RB cord-005453-4057qib7 7958 14 : : : cord-005453-4057qib7 7958 15 haploSCT haploSCT NNP cord-005453-4057qib7 7958 16 following follow VBG cord-005453-4057qib7 7958 17 TBF tbf NN cord-005453-4057qib7 7958 18 conditioning conditioning NN cord-005453-4057qib7 7958 19 , , , cord-005453-4057qib7 7958 20 PT PT NNP cord-005453-4057qib7 7958 21 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 7958 22 and and CC cord-005453-4057qib7 7958 23 tacrolimus tacrolimus NN cord-005453-4057qib7 7958 24 as as IN cord-005453-4057qib7 7958 25 GVHD GVHD NNP cord-005453-4057qib7 7958 26 prophylaxis prophylaxis NN cord-005453-4057qib7 7958 27 Background background NN cord-005453-4057qib7 7958 28 : : : cord-005453-4057qib7 7959 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 7959 2 stem stem NN cord-005453-4057qib7 7959 3 cell cell NN cord-005453-4057qib7 7959 4 transplantation transplantation NN cord-005453-4057qib7 7959 5 is be VBZ cord-005453-4057qib7 7959 6 an an DT cord-005453-4057qib7 7959 7 effective effective JJ cord-005453-4057qib7 7959 8 therapy therapy NN cord-005453-4057qib7 7959 9 for for IN cord-005453-4057qib7 7959 10 a a DT cord-005453-4057qib7 7959 11 variety variety NN cord-005453-4057qib7 7959 12 of of IN cord-005453-4057qib7 7959 13 severe severe JJ cord-005453-4057qib7 7959 14 hematological hematological JJ cord-005453-4057qib7 7959 15 diseases disease NNS cord-005453-4057qib7 7959 16 . . . cord-005453-4057qib7 7960 1 In in IN cord-005453-4057qib7 7960 2 last last JJ cord-005453-4057qib7 7960 3 decades decade NNS cord-005453-4057qib7 7960 4 , , , cord-005453-4057qib7 7960 5 haploidentical haploidentical JJ cord-005453-4057qib7 7960 6 SCT SCT NNP cord-005453-4057qib7 7960 7 ( ( -LRB- cord-005453-4057qib7 7960 8 haploSCT haploSCT NNP cord-005453-4057qib7 7960 9 ) ) -RRB- cord-005453-4057qib7 7960 10 followed follow VBN cord-005453-4057qib7 7960 11 by by IN cord-005453-4057qib7 7960 12 PTCy PTCy NNS cord-005453-4057qib7 7960 13 as as IN cord-005453-4057qib7 7960 14 GvHD GvHD NNP cord-005453-4057qib7 7960 15 prophylaxis prophylaxis NN cord-005453-4057qib7 7960 16 has have VBZ cord-005453-4057qib7 7960 17 been be VBN cord-005453-4057qib7 7960 18 reported report VBN cord-005453-4057qib7 7960 19 as as IN cord-005453-4057qib7 7960 20 a a DT cord-005453-4057qib7 7960 21 valid valid JJ cord-005453-4057qib7 7960 22 alternative alternative NN cord-005453-4057qib7 7960 23 for for IN cord-005453-4057qib7 7960 24 patients patient NNS cord-005453-4057qib7 7960 25 who who WP cord-005453-4057qib7 7960 26 lack lack VBP cord-005453-4057qib7 7960 27 an an DT cord-005453-4057qib7 7960 28 HLA HLA NNP cord-005453-4057qib7 7960 29 matched match VBN cord-005453-4057qib7 7960 30 donor donor NN cord-005453-4057qib7 7960 31 . . . cord-005453-4057qib7 7961 1 We -PRON- PRP cord-005453-4057qib7 7961 2 therefore therefore RB cord-005453-4057qib7 7961 3 analysed analyse VBD cord-005453-4057qib7 7961 4 outcomes outcome NNS cord-005453-4057qib7 7961 5 with with IN cord-005453-4057qib7 7961 6 this this DT cord-005453-4057qib7 7961 7 . . . cord-005453-4057qib7 7962 1 Methods method NNS cord-005453-4057qib7 7962 2 : : : cord-005453-4057qib7 7962 3 38 38 CD cord-005453-4057qib7 7962 4 patients patient NNS cord-005453-4057qib7 7962 5 without without IN cord-005453-4057qib7 7962 6 HLA HLA NNP cord-005453-4057qib7 7962 7 - - HYPH cord-005453-4057qib7 7962 8 matched match VBN cord-005453-4057qib7 7962 9 donor donor NN cord-005453-4057qib7 7962 10 received receive VBD cord-005453-4057qib7 7962 11 a a DT cord-005453-4057qib7 7962 12 haploSCT haplosct NN cord-005453-4057qib7 7962 13 between between IN cord-005453-4057qib7 7962 14 04/13 04/13 CD cord-005453-4057qib7 7962 15 and and CC cord-005453-4057qib7 7962 16 08/18 08/18 CD cord-005453-4057qib7 7962 17 . . . cord-005453-4057qib7 7963 1 Thiotepa Thiotepa NNP cord-005453-4057qib7 7963 2 5 5 CD cord-005453-4057qib7 7963 3 mg mg NNP cord-005453-4057qib7 7963 4 / / SYM cord-005453-4057qib7 7963 5 kg kg NN cord-005453-4057qib7 7963 6 ( ( -LRB- cord-005453-4057qib7 7963 7 2 2 CD cord-005453-4057qib7 7963 8 days day NNS cord-005453-4057qib7 7963 9 ) ) -RRB- cord-005453-4057qib7 7963 10 , , , cord-005453-4057qib7 7963 11 fludarabine fludarabine VBP cord-005453-4057qib7 7963 12 50 50 CD cord-005453-4057qib7 7963 13 mg mg NNP cord-005453-4057qib7 7963 14 / / SYM cord-005453-4057qib7 7963 15 m2 m2 NNP cord-005453-4057qib7 7963 16 ( ( -LRB- cord-005453-4057qib7 7963 17 3 3 CD cord-005453-4057qib7 7963 18 days day NNS cord-005453-4057qib7 7963 19 ) ) -RRB- cord-005453-4057qib7 7963 20 and and CC cord-005453-4057qib7 7963 21 oral oral JJ cord-005453-4057qib7 7963 22 busulfan busulfan NN cord-005453-4057qib7 7964 1 1 1 CD cord-005453-4057qib7 7964 2 mg mg NNP cord-005453-4057qib7 7964 3 / / SYM cord-005453-4057qib7 7964 4 kg/6 kg/6 NNP cord-005453-4057qib7 7964 5 h h NNP cord-005453-4057qib7 7964 6 ( ( -LRB- cord-005453-4057qib7 7964 7 3 3 CD cord-005453-4057qib7 7964 8 days day NNS cord-005453-4057qib7 7964 9 , , , cord-005453-4057qib7 7964 10 with with IN cord-005453-4057qib7 7964 11 PKD PKD NNP cord-005453-4057qib7 7964 12 dose dose NN cord-005453-4057qib7 7964 13 adjustments adjustment NNS cord-005453-4057qib7 7964 14 ) ) -RRB- cord-005453-4057qib7 7964 15 was be VBD cord-005453-4057qib7 7964 16 used use VBN cord-005453-4057qib7 7964 17 as as IN cord-005453-4057qib7 7964 18 conditioning conditioning NN cord-005453-4057qib7 7964 19 regiment regiment NN cord-005453-4057qib7 7964 20 ; ; : cord-005453-4057qib7 7964 21 in in IN cord-005453-4057qib7 7964 22 patients patient NNS cord-005453-4057qib7 7964 23 > > XX cord-005453-4057qib7 7964 24 55 55 CD cord-005453-4057qib7 7964 25 years year NNS cord-005453-4057qib7 7964 26 busulfan busulfan NNP cord-005453-4057qib7 7964 27 administration administration NNP cord-005453-4057qib7 7964 28 was be VBD cord-005453-4057qib7 7964 29 limited limit VBN cord-005453-4057qib7 7964 30 to to IN cord-005453-4057qib7 7964 31 two two CD cord-005453-4057qib7 7964 32 days day NNS cord-005453-4057qib7 7964 33 . . . cord-005453-4057qib7 7965 1 GvHD GvHD NNP cord-005453-4057qib7 7965 2 prophylaxis prophylaxis NN cord-005453-4057qib7 7965 3 consisted consist VBD cord-005453-4057qib7 7965 4 of of IN cord-005453-4057qib7 7965 5 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 7965 6 50 50 CD cord-005453-4057qib7 7965 7 mg mg NNP cord-005453-4057qib7 7965 8 / / SYM cord-005453-4057qib7 7965 9 kg kg NNS cord-005453-4057qib7 7965 10 on on IN cord-005453-4057qib7 7965 11 day day NN cord-005453-4057qib7 7965 12 +3 +3 NN cord-005453-4057qib7 7965 13 and and CC cord-005453-4057qib7 7965 14 +4 +4 NN cord-005453-4057qib7 7965 15 , , , cord-005453-4057qib7 7965 16 and and CC cord-005453-4057qib7 7965 17 tacrolimus tacrolimus NN cord-005453-4057qib7 7965 18 as as IN cord-005453-4057qib7 7965 19 a a DT cord-005453-4057qib7 7965 20 continuous continuous JJ cord-005453-4057qib7 7965 21 iv iv CD cord-005453-4057qib7 7965 22 infusion infusion NN cord-005453-4057qib7 7965 23 from from IN cord-005453-4057qib7 7965 24 day day NN cord-005453-4057qib7 7965 25 +5 +5 NFP cord-005453-4057qib7 7965 26 . . . cord-005453-4057qib7 7966 1 All all DT cord-005453-4057qib7 7966 2 patients patient NNS cord-005453-4057qib7 7966 3 received receive VBD cord-005453-4057qib7 7966 4 PBSC PBSC NNP cord-005453-4057qib7 7966 5 as as IN cord-005453-4057qib7 7966 6 the the DT cord-005453-4057qib7 7966 7 stem stem NN cord-005453-4057qib7 7966 8 cell cell NN cord-005453-4057qib7 7966 9 source source NN cord-005453-4057qib7 7966 10 . . . cord-005453-4057qib7 7967 1 Outcomes outcome NNS cord-005453-4057qib7 7967 2 analysed analyse VBN cord-005453-4057qib7 7967 3 were be VBD cord-005453-4057qib7 7967 4 overall overall JJ cord-005453-4057qib7 7967 5 survival survival NN cord-005453-4057qib7 7967 6 ( ( -LRB- cord-005453-4057qib7 7967 7 OS OS NNP cord-005453-4057qib7 7967 8 ) ) -RRB- cord-005453-4057qib7 7967 9 , , , cord-005453-4057qib7 7967 10 progression progression NN cord-005453-4057qib7 7967 11 free free JJ cord-005453-4057qib7 7967 12 survival survival NN cord-005453-4057qib7 7967 13 ( ( -LRB- cord-005453-4057qib7 7967 14 PFS PFS NNP cord-005453-4057qib7 7967 15 ) ) -RRB- cord-005453-4057qib7 7967 16 ; ; , cord-005453-4057qib7 7967 17 cumulative cumulative JJ cord-005453-4057qib7 7967 18 incidences incidence NNS cord-005453-4057qib7 7967 19 ( ( -LRB- cord-005453-4057qib7 7967 20 CI CI NNP cord-005453-4057qib7 7967 21 ) ) -RRB- cord-005453-4057qib7 7967 22 of of IN cord-005453-4057qib7 7967 23 GvHD GvHD NNP cord-005453-4057qib7 7967 24 , , , cord-005453-4057qib7 7967 25 relapse relapse NN cord-005453-4057qib7 7967 26 and and CC cord-005453-4057qib7 7967 27 non non JJ cord-005453-4057qib7 7967 28 - - JJ cord-005453-4057qib7 7967 29 relapsed relapsed JJ cord-005453-4057qib7 7967 30 mortality mortality NN cord-005453-4057qib7 7967 31 ( ( -LRB- cord-005453-4057qib7 7967 32 NRM NRM NNP cord-005453-4057qib7 7967 33 ) ) -RRB- cord-005453-4057qib7 7967 34 . . . cord-005453-4057qib7 7968 1 Results result NNS cord-005453-4057qib7 7968 2 : : : cord-005453-4057qib7 7969 1 Median median JJ cord-005453-4057qib7 7969 2 ages age NNS cord-005453-4057qib7 7969 3 was be VBD cord-005453-4057qib7 7969 4 54 54 CD cord-005453-4057qib7 7970 1 ( ( -LRB- cord-005453-4057qib7 7970 2 range range VBP cord-005453-4057qib7 7970 3 25 25 CD cord-005453-4057qib7 7970 4 - - SYM cord-005453-4057qib7 7970 5 71 71 CD cord-005453-4057qib7 7970 6 ) ) -RRB- cord-005453-4057qib7 7970 7 . . . cord-005453-4057qib7 7971 1 53 53 CD cord-005453-4057qib7 7971 2 % % NN cord-005453-4057qib7 7971 3 male male NN cord-005453-4057qib7 7971 4 and and CC cord-005453-4057qib7 7971 5 47 47 CD cord-005453-4057qib7 7971 6 % % NN cord-005453-4057qib7 7971 7 female female NN cord-005453-4057qib7 7971 8 . . . cord-005453-4057qib7 7972 1 Diagnoses diagnosis NNS cord-005453-4057qib7 7972 2 were be VBD cord-005453-4057qib7 7972 3 : : : cord-005453-4057qib7 7972 4 AML AML NNP cord-005453-4057qib7 7972 5 20 20 CD cord-005453-4057qib7 7972 6 ( ( -LRB- cord-005453-4057qib7 7972 7 53 53 CD cord-005453-4057qib7 7972 8 % % NN cord-005453-4057qib7 7972 9 ) ) -RRB- cord-005453-4057qib7 7972 10 , , , cord-005453-4057qib7 7972 11 MDS MDS NNP cord-005453-4057qib7 7972 12 7 7 CD cord-005453-4057qib7 7972 13 ( ( -LRB- cord-005453-4057qib7 7972 14 18 18 CD cord-005453-4057qib7 7972 15 % % NN cord-005453-4057qib7 7972 16 ) ) -RRB- cord-005453-4057qib7 7972 17 , , , cord-005453-4057qib7 7972 18 ALL all DT cord-005453-4057qib7 7972 19 5 5 CD cord-005453-4057qib7 7972 20 ( ( -LRB- cord-005453-4057qib7 7972 21 13 13 CD cord-005453-4057qib7 7972 22 % % NN cord-005453-4057qib7 7972 23 ) ) -RRB- cord-005453-4057qib7 7972 24 , , , cord-005453-4057qib7 7972 25 HL HL NNP cord-005453-4057qib7 7972 26 and and CC cord-005453-4057qib7 7972 27 NHL NHL NNP cord-005453-4057qib7 7972 28 5 5 CD cord-005453-4057qib7 7972 29 ( ( -LRB- cord-005453-4057qib7 7972 30 13 13 CD cord-005453-4057qib7 7972 31 % % NN cord-005453-4057qib7 7972 32 ) ) -RRB- cord-005453-4057qib7 7972 33 , , , cord-005453-4057qib7 7972 34 and and CC cord-005453-4057qib7 7972 35 1 1 CD cord-005453-4057qib7 7972 36 MM MM NNP cord-005453-4057qib7 7972 37 ( ( -LRB- cord-005453-4057qib7 7972 38 3 3 CD cord-005453-4057qib7 7972 39 % % NN cord-005453-4057qib7 7972 40 ) ) -RRB- cord-005453-4057qib7 7972 41 . . . cord-005453-4057qib7 7973 1 37 37 CD cord-005453-4057qib7 7973 2 % % NN cord-005453-4057qib7 7973 3 ( ( -LRB- cord-005453-4057qib7 7973 4 N n CD cord-005453-4057qib7 7973 5 14 14 CD cord-005453-4057qib7 7973 6 ) ) -RRB- cord-005453-4057qib7 7973 7 were be VBD cord-005453-4057qib7 7973 8 transplanted transplant VBN cord-005453-4057qib7 7973 9 in in IN cord-005453-4057qib7 7973 10 early early JJ cord-005453-4057qib7 7973 11 disease disease NN cord-005453-4057qib7 7973 12 status status NN cord-005453-4057qib7 7973 13 , , , cord-005453-4057qib7 7973 14 while while IN cord-005453-4057qib7 7973 15 most most JJS cord-005453-4057qib7 7973 16 cases case NNS cord-005453-4057qib7 7973 17 ( ( -LRB- cord-005453-4057qib7 7973 18 63 63 CD cord-005453-4057qib7 7973 19 % % NN cord-005453-4057qib7 7973 20 ) ) -RRB- cord-005453-4057qib7 7973 21 were be VBD cord-005453-4057qib7 7973 22 in in IN cord-005453-4057qib7 7973 23 advanced advanced JJ cord-005453-4057qib7 7973 24 status status NN cord-005453-4057qib7 7973 25 , , , cord-005453-4057qib7 7973 26 including include VBG cord-005453-4057qib7 7973 27 , , , cord-005453-4057qib7 7973 28 second second JJ cord-005453-4057qib7 7973 29 / / SYM cord-005453-4057qib7 7973 30 third third JJ cord-005453-4057qib7 7973 31 CR CR NNP cord-005453-4057qib7 7973 32 ( ( -LRB- cord-005453-4057qib7 7973 33 29 29 CD cord-005453-4057qib7 7973 34 % % NN cord-005453-4057qib7 7973 35 , , , cord-005453-4057qib7 7973 36 N n CD cord-005453-4057qib7 7973 37 11 11 CD cord-005453-4057qib7 7973 38 ) ) -RRB- cord-005453-4057qib7 7973 39 , , , cord-005453-4057qib7 7973 40 one one CD cord-005453-4057qib7 7973 41 ( ( -LRB- cord-005453-4057qib7 7973 42 3 3 CD cord-005453-4057qib7 7973 43 % % NN cord-005453-4057qib7 7973 44 ) ) -RRB- cord-005453-4057qib7 7974 1 in in IN cord-005453-4057qib7 7974 2 aplasia aplasia NNP cord-005453-4057qib7 7974 3 without without IN cord-005453-4057qib7 7974 4 progressive progressive JJ cord-005453-4057qib7 7974 5 disease disease NN cord-005453-4057qib7 7974 6 and and CC cord-005453-4057qib7 7974 7 23 23 CD cord-005453-4057qib7 7974 8 % % NN cord-005453-4057qib7 7974 9 ( ( -LRB- cord-005453-4057qib7 7974 10 N N NNP cord-005453-4057qib7 7974 11 9 9 CD cord-005453-4057qib7 7974 12 ) ) -RRB- cord-005453-4057qib7 7974 13 had have VBD cord-005453-4057qib7 7974 14 active active JJ cord-005453-4057qib7 7974 15 / / SYM cord-005453-4057qib7 7974 16 progression progression NN cord-005453-4057qib7 7974 17 disease disease NN cord-005453-4057qib7 7974 18 , , , cord-005453-4057qib7 7974 19 8 8 CD cord-005453-4057qib7 7974 20 % % NN cord-005453-4057qib7 7974 21 ( ( -LRB- cord-005453-4057qib7 7974 22 N N NNP cord-005453-4057qib7 7974 23 3 3 CD cord-005453-4057qib7 7974 24 ) ) -RRB- cord-005453-4057qib7 7974 25 had have VBD cord-005453-4057qib7 7974 26 stable stable JJ cord-005453-4057qib7 7974 27 disease disease NN cord-005453-4057qib7 7974 28 ; ; : cord-005453-4057qib7 7974 29 four four CD cord-005453-4057qib7 7974 30 cases case NNS cord-005453-4057qib7 7974 31 were be VBD cord-005453-4057qib7 7974 32 second second JJ cord-005453-4057qib7 7974 33 aloSCT aloSCT NNP cord-005453-4057qib7 7974 34 . . . cord-005453-4057qib7 7975 1 Thus thus RB cord-005453-4057qib7 7975 2 , , , cord-005453-4057qib7 7975 3 50 50 CD cord-005453-4057qib7 7975 4 % % NN cord-005453-4057qib7 7975 5 of of IN cord-005453-4057qib7 7975 6 patients patient NNS cord-005453-4057qib7 7975 7 had have VBD cord-005453-4057qib7 7975 8 a a DT cord-005453-4057qib7 7975 9 high high JJ cord-005453-4057qib7 7975 10 or or CC cord-005453-4057qib7 7975 11 very very RB cord-005453-4057qib7 7975 12 high high JJ cord-005453-4057qib7 7975 13 rDRI rDRI NNS cord-005453-4057qib7 7975 14 and and CC cord-005453-4057qib7 7975 15 50 50 CD cord-005453-4057qib7 7975 16 % % NN cord-005453-4057qib7 7975 17 had have VBD cord-005453-4057qib7 7975 18 intermediate intermediate JJ cord-005453-4057qib7 7975 19 . . . cord-005453-4057qib7 7976 1 EBMT EBMT NNP cord-005453-4057qib7 7976 2 score score NN cord-005453-4057qib7 7976 3 was be VBD cord-005453-4057qib7 7976 4 ≤ ≤ NNP cord-005453-4057qib7 7976 5 4 4 CD cord-005453-4057qib7 7976 6 was be VBD cord-005453-4057qib7 7976 7 in in IN cord-005453-4057qib7 7976 8 58 58 CD cord-005453-4057qib7 7976 9 % % NN cord-005453-4057qib7 7976 10 of of IN cord-005453-4057qib7 7976 11 patients patient NNS cord-005453-4057qib7 7976 12 ( ( -LRB- cord-005453-4057qib7 7976 13 N n CD cord-005453-4057qib7 7976 14 22 22 CD cord-005453-4057qib7 7976 15 ) ) -RRB- cord-005453-4057qib7 7976 16 . . . cord-005453-4057qib7 7977 1 The the DT cord-005453-4057qib7 7977 2 donor donor NN cord-005453-4057qib7 7977 3 was be VBD cord-005453-4057qib7 7977 4 as as IN cord-005453-4057qib7 7977 5 son/ son/ CD cord-005453-4057qib7 7977 6 daughter daughter NN cord-005453-4057qib7 7977 7 in in IN cord-005453-4057qib7 7977 8 50 50 CD cord-005453-4057qib7 7977 9 % % NN cord-005453-4057qib7 7977 10 , , , cord-005453-4057qib7 7977 11 29 29 CD cord-005453-4057qib7 7977 12 % % NN cord-005453-4057qib7 7977 13 a a DT cord-005453-4057qib7 7977 14 sibling sibling NN cord-005453-4057qib7 7977 15 and and CC cord-005453-4057qib7 7977 16 21 21 CD cord-005453-4057qib7 7977 17 % % NN cord-005453-4057qib7 7977 18 a a DT cord-005453-4057qib7 7977 19 patient patient NN cord-005453-4057qib7 7977 20 's 's POS cord-005453-4057qib7 7977 21 mother mother NN cord-005453-4057qib7 7977 22 . . . cord-005453-4057qib7 7978 1 Median median JJ cord-005453-4057qib7 7978 2 time time NN cord-005453-4057qib7 7978 3 to to IN cord-005453-4057qib7 7978 4 neutrophil neutrophil NN cord-005453-4057qib7 7978 5 ( ( -LRB- cord-005453-4057qib7 7978 6 0.5x10e9 0.5x10e9 NNP cord-005453-4057qib7 7978 7 / / SYM cord-005453-4057qib7 7978 8 L l NN cord-005453-4057qib7 7978 9 ) ) -RRB- cord-005453-4057qib7 7978 10 and and CC cord-005453-4057qib7 7978 11 platelet platelet NN cord-005453-4057qib7 7978 12 ( ( -LRB- cord-005453-4057qib7 7978 13 > > NFP cord-005453-4057qib7 7978 14 20x10e9 20x10e9 CD cord-005453-4057qib7 7978 15 / / SYM cord-005453-4057qib7 7978 16 L l NN cord-005453-4057qib7 7978 17 ) ) -RRB- cord-005453-4057qib7 7978 18 recoveries recovery NNS cord-005453-4057qib7 7978 19 were be VBD cord-005453-4057qib7 7978 20 +20 +20 CD cord-005453-4057qib7 7978 21 and and CC cord-005453-4057qib7 7978 22 +27 +27 NNP cord-005453-4057qib7 7978 23 days day NNS cord-005453-4057qib7 7978 24 , , , cord-005453-4057qib7 7978 25 respectively respectively RB cord-005453-4057qib7 7978 26 ( ( -LRB- cord-005453-4057qib7 7978 27 G G NNP cord-005453-4057qib7 7978 28 - - HYPH cord-005453-4057qib7 7978 29 CSF CSF NNP cord-005453-4057qib7 7978 30 was be VBD cord-005453-4057qib7 7978 31 not not RB cord-005453-4057qib7 7978 32 used use VBN cord-005453-4057qib7 7978 33 ) ) -RRB- cord-005453-4057qib7 7978 34 . . . cord-005453-4057qib7 7979 1 Only only RB cord-005453-4057qib7 7979 2 one one CD cord-005453-4057qib7 7979 3 patient patient NN cord-005453-4057qib7 7979 4 had have VBD cord-005453-4057qib7 7979 5 a a DT cord-005453-4057qib7 7979 6 primary primary JJ cord-005453-4057qib7 7979 7 graft graft NN cord-005453-4057qib7 7979 8 failure failure NN cord-005453-4057qib7 7979 9 attributed attribute VBN cord-005453-4057qib7 7979 10 to to IN cord-005453-4057qib7 7979 11 anti anti JJ cord-005453-4057qib7 7979 12 - - JJ cord-005453-4057qib7 7979 13 HLA HLA NNP cord-005453-4057qib7 7979 14 donor donor NN cord-005453-4057qib7 7979 15 specific specific JJ cord-005453-4057qib7 7979 16 antibodies antibody NNS cord-005453-4057qib7 7979 17 . . . cord-005453-4057qib7 7980 1 Median median JJ cord-005453-4057qib7 7980 2 follow follow VBP cord-005453-4057qib7 7980 3 up up RP cord-005453-4057qib7 7980 4 in in IN cord-005453-4057qib7 7980 5 survivor survivor NN cord-005453-4057qib7 7980 6 is be VBZ cord-005453-4057qib7 7980 7 22 22 CD cord-005453-4057qib7 7980 8 months month NNS cord-005453-4057qib7 7980 9 ( ( -LRB- cord-005453-4057qib7 7980 10 range range NNP cord-005453-4057qib7 7980 11 2 2 CD cord-005453-4057qib7 7980 12 - - SYM cord-005453-4057qib7 7980 13 63 63 CD cord-005453-4057qib7 7980 14 ) ) -RRB- cord-005453-4057qib7 7980 15 . . . cord-005453-4057qib7 7981 1 Overall overall JJ cord-005453-4057qib7 7981 2 survival survival NN cord-005453-4057qib7 7981 3 is be VBZ cord-005453-4057qib7 7981 4 81±6.5 81±6.5 CD cord-005453-4057qib7 7981 5 % % NN cord-005453-4057qib7 7981 6 ( ( -LRB- cord-005453-4057qib7 7981 7 at at IN cord-005453-4057qib7 7981 8 12 12 CD cord-005453-4057qib7 7981 9 months month NNS cord-005453-4057qib7 7981 10 ) ) -RRB- cord-005453-4057qib7 7981 11 and and CC cord-005453-4057qib7 7981 12 61±9 61±9 CD cord-005453-4057qib7 7981 13 % % NN cord-005453-4057qib7 7981 14 ( ( -LRB- cord-005453-4057qib7 7981 15 at at IN cord-005453-4057qib7 7981 16 63 63 CD cord-005453-4057qib7 7981 17 months month NNS cord-005453-4057qib7 7981 18 ) ) -RRB- cord-005453-4057qib7 7981 19 . . . cord-005453-4057qib7 7982 1 PFS PFS NNP cord-005453-4057qib7 7982 2 is be VBZ cord-005453-4057qib7 7982 3 67±8 67±8 CD cord-005453-4057qib7 7982 4 % % NN cord-005453-4057qib7 7982 5 and and CC cord-005453-4057qib7 7982 6 52±9 52±9 CD cord-005453-4057qib7 7982 7 % % NN cord-005453-4057qib7 7982 8 respectively respectively RB cord-005453-4057qib7 7982 9 . . . cord-005453-4057qib7 7983 1 The the DT cord-005453-4057qib7 7983 2 cumulative cumulative JJ cord-005453-4057qib7 7983 3 incidence incidence NN cord-005453-4057qib7 7983 4 of of IN cord-005453-4057qib7 7983 5 relapse relapse NN cord-005453-4057qib7 7983 6 was be VBD cord-005453-4057qib7 7983 7 20 20 CD cord-005453-4057qib7 7983 8 % % NN cord-005453-4057qib7 7983 9 and and CC cord-005453-4057qib7 7983 10 35 35 CD cord-005453-4057qib7 7983 11 % % NN cord-005453-4057qib7 7983 12 , , , cord-005453-4057qib7 7983 13 respectively respectively RB cord-005453-4057qib7 7983 14 , , , cord-005453-4057qib7 7983 15 while while IN cord-005453-4057qib7 7983 16 NRM NRM NNP cord-005453-4057qib7 7983 17 is be VBZ cord-005453-4057qib7 7983 18 13 13 CD cord-005453-4057qib7 7983 19 % % NN cord-005453-4057qib7 7983 20 at at IN cord-005453-4057qib7 7983 21 63 63 CD cord-005453-4057qib7 7983 22 months month NNS cord-005453-4057qib7 7983 23 . . . cord-005453-4057qib7 7984 1 Day day NN cord-005453-4057qib7 7984 2 +120 +120 RB cord-005453-4057qib7 7984 3 , , , cord-005453-4057qib7 7984 4 grade grade NN cord-005453-4057qib7 7984 5 2 2 CD cord-005453-4057qib7 7984 6 - - SYM cord-005453-4057qib7 7984 7 4 4 CD cord-005453-4057qib7 7984 8 acute acute JJ cord-005453-4057qib7 7984 9 GvHD GvHD NNP cord-005453-4057qib7 7984 10 were be VBD cord-005453-4057qib7 7984 11 13 13 CD cord-005453-4057qib7 7984 12 % % NN cord-005453-4057qib7 7984 13 , , , cord-005453-4057qib7 7984 14 while while IN cord-005453-4057qib7 7984 15 mild/ mild/ VBG cord-005453-4057qib7 7984 16 moderate moderate JJ cord-005453-4057qib7 7984 17 and and CC cord-005453-4057qib7 7984 18 severe severe JJ cord-005453-4057qib7 7984 19 chronic chronic JJ cord-005453-4057qib7 7984 20 GvHD gvhd NN cord-005453-4057qib7 7984 21 were be VBD cord-005453-4057qib7 7984 22 6 6 CD cord-005453-4057qib7 7984 23 % % NN cord-005453-4057qib7 7984 24 and and CC cord-005453-4057qib7 7984 25 3 3 CD cord-005453-4057qib7 7984 26 % % NN cord-005453-4057qib7 7984 27 respectively respectively RB cord-005453-4057qib7 7984 28 . . . cord-005453-4057qib7 7985 1 EBMT EBMT NNP cord-005453-4057qib7 7985 2 ≤ ≤ NNP cord-005453-4057qib7 7985 3 4 4 CD cord-005453-4057qib7 7985 4 and and CC cord-005453-4057qib7 7985 5 first first JJ cord-005453-4057qib7 7985 6 aloSCT aloSCT NNP cord-005453-4057qib7 7985 7 were be VBD cord-005453-4057qib7 7985 8 the the DT cord-005453-4057qib7 7985 9 only only JJ cord-005453-4057qib7 7985 10 variables variable NNS cord-005453-4057qib7 7985 11 to to TO cord-005453-4057qib7 7985 12 clearly clearly RB cord-005453-4057qib7 7985 13 impact impact VB cord-005453-4057qib7 7985 14 60-months 60-months CD cord-005453-4057qib7 7985 15 OS os NN cord-005453-4057qib7 7985 16 in in IN cord-005453-4057qib7 7985 17 univariate univariate JJ cord-005453-4057qib7 7985 18 analysis analysis NN cord-005453-4057qib7 7985 19 . . . cord-005453-4057qib7 7986 1 A a DT cord-005453-4057qib7 7986 2 combined combined JJ cord-005453-4057qib7 7986 3 covariate covariate NN cord-005453-4057qib7 7986 4 of of IN cord-005453-4057qib7 7986 5 ebmt ebmt NNP cord-005453-4057qib7 7986 6 ≤ ≤ NNP cord-005453-4057qib7 7986 7 4-no 4-no CD cord-005453-4057qib7 7986 8 prior prior IN cord-005453-4057qib7 7986 9 aloSCT aloSCT NNP cord-005453-4057qib7 7986 10 vs vs IN cord-005453-4057qib7 7986 11 other other JJ cord-005453-4057qib7 7986 12 patients patient NNS cord-005453-4057qib7 7986 13 showed show VBD cord-005453-4057qib7 7986 14 a a DT cord-005453-4057qib7 7986 15 60 60 CD cord-005453-4057qib7 7986 16 month month NN cord-005453-4057qib7 7986 17 OS OS NNP cord-005453-4057qib7 7986 18 81±13 81±13 NNP cord-005453-4057qib7 7986 19 % % NN cord-005453-4057qib7 7986 20 vs vs IN cord-005453-4057qib7 7986 21 38±12 38±12 NNP cord-005453-4057qib7 7986 22 % % NN cord-005453-4057qib7 7986 23 ( ( -LRB- cord-005453-4057qib7 7986 24 p p NN cord-005453-4057qib7 7986 25 0.001 0.001 CD cord-005453-4057qib7 7986 26 ) ) -RRB- cord-005453-4057qib7 7986 27 , , , cord-005453-4057qib7 7986 28 PFS PFS NNP cord-005453-4057qib7 7986 29 65±13 65±13 NNP cord-005453-4057qib7 7986 30 % % NN cord-005453-4057qib7 7986 31 vs vs IN cord-005453-4057qib7 7986 32 35±11 35±11 NNP cord-005453-4057qib7 7986 33 % % NN cord-005453-4057qib7 7986 34 ( ( -LRB- cord-005453-4057qib7 7986 35 p p NN cord-005453-4057qib7 7986 36 0.014 0.014 CD cord-005453-4057qib7 7986 37 ) ) -RRB- cord-005453-4057qib7 7986 38 and and CC cord-005453-4057qib7 7986 39 NRM NRM NNP cord-005453-4057qib7 7986 40 0 0 CD cord-005453-4057qib7 7986 41 % % NN cord-005453-4057qib7 7986 42 vs vs IN cord-005453-4057qib7 7986 43 29 29 CD cord-005453-4057qib7 7986 44 % % NN cord-005453-4057qib7 7986 45 ( ( -LRB- cord-005453-4057qib7 7986 46 p p NN cord-005453-4057qib7 7986 47 0.008 0.008 CD cord-005453-4057qib7 7986 48 ) ) -RRB- cord-005453-4057qib7 7987 1 but but CC cord-005453-4057qib7 7987 2 without without IN cord-005453-4057qib7 7987 3 impact impact NN cord-005453-4057qib7 7987 4 on on IN cord-005453-4057qib7 7987 5 relapse relapse NN cord-005453-4057qib7 7987 6 34 34 CD cord-005453-4057qib7 7987 7 % % NN cord-005453-4057qib7 7987 8 vs vs IN cord-005453-4057qib7 7987 9 35 35 CD cord-005453-4057qib7 7987 10 % % NN cord-005453-4057qib7 7987 11 ( ( -LRB- cord-005453-4057qib7 7987 12 p p NN cord-005453-4057qib7 7987 13 0.68 0.68 CD cord-005453-4057qib7 7987 14 ) ) -RRB- cord-005453-4057qib7 7987 15 . . . cord-005453-4057qib7 7988 1 Conclusions conclusion NNS cord-005453-4057qib7 7988 2 : : : cord-005453-4057qib7 7988 3 HaploSCT haplosct XX cord-005453-4057qib7 7989 1 with with IN cord-005453-4057qib7 7989 2 an an DT cord-005453-4057qib7 7989 3 age age NN cord-005453-4057qib7 7989 4 - - HYPH cord-005453-4057qib7 7989 5 adapted adapt VBN cord-005453-4057qib7 7989 6 TBF tbf NN cord-005453-4057qib7 7989 7 conditioning conditioning NN cord-005453-4057qib7 7989 8 regimen regimen NN cord-005453-4057qib7 7989 9 , , , cord-005453-4057qib7 7989 10 PBSC PBSC NNP cord-005453-4057qib7 7989 11 and and CC cord-005453-4057qib7 7989 12 PTCy PTCy NNS cord-005453-4057qib7 7989 13 followed follow VBN cord-005453-4057qib7 7989 14 by by IN cord-005453-4057qib7 7989 15 tacrolimus tacrolimus NNP cord-005453-4057qib7 7989 16 , , , cord-005453-4057qib7 7989 17 led lead VBD cord-005453-4057qib7 7989 18 to to IN cord-005453-4057qib7 7989 19 very very RB cord-005453-4057qib7 7989 20 encouraging encouraging JJ cord-005453-4057qib7 7989 21 results result NNS cord-005453-4057qib7 7989 22 , , , cord-005453-4057qib7 7989 23 mainly mainly RB cord-005453-4057qib7 7989 24 in in IN cord-005453-4057qib7 7989 25 patients patient NNS cord-005453-4057qib7 7989 26 with with IN cord-005453-4057qib7 7989 27 a a DT cord-005453-4057qib7 7989 28 low low JJ cord-005453-4057qib7 7989 29 EBMT EBMT NNP cord-005453-4057qib7 7989 30 score score NN cord-005453-4057qib7 7989 31 and and CC cord-005453-4057qib7 7989 32 as as IN cord-005453-4057qib7 7989 33 a a DT cord-005453-4057qib7 7989 34 first first JJ cord-005453-4057qib7 7989 35 aloSCT alosct NN cord-005453-4057qib7 7989 36 . . . cord-005453-4057qib7 7990 1 Although although IN cord-005453-4057qib7 7990 2 formerly formerly RB cord-005453-4057qib7 7990 3 considered consider VBN cord-005453-4057qib7 7990 4 as as IN cord-005453-4057qib7 7990 5 a a DT cord-005453-4057qib7 7990 6 last last JJ cord-005453-4057qib7 7990 7 aloSCT aloSCT NNP cord-005453-4057qib7 7990 8 strategy strategy NN cord-005453-4057qib7 7990 9 , , , cord-005453-4057qib7 7990 10 we -PRON- PRP cord-005453-4057qib7 7990 11 now now RB cord-005453-4057qib7 7990 12 agree agree VBP cord-005453-4057qib7 7990 13 that that IN cord-005453-4057qib7 7990 14 the the DT cord-005453-4057qib7 7990 15 time time NN cord-005453-4057qib7 7990 16 has have VBZ cord-005453-4057qib7 7990 17 come come VBN cord-005453-4057qib7 7990 18 to to TO cord-005453-4057qib7 7990 19 compare compare VB cord-005453-4057qib7 7990 20 this this DT cord-005453-4057qib7 7990 21 strategy strategy NN cord-005453-4057qib7 7990 22 with with IN cord-005453-4057qib7 7990 23 HLA HLA NNP cord-005453-4057qib7 7990 24 MUD MUD NNP cord-005453-4057qib7 7990 25 ( ( -LRB- cord-005453-4057qib7 7990 26 and and CC cord-005453-4057qib7 7990 27 even even RB cord-005453-4057qib7 7990 28 elderly elderly JJ cord-005453-4057qib7 7990 29 sibling sibling NN cord-005453-4057qib7 7990 30 donors donor NNS cord-005453-4057qib7 7990 31 ) ) -RRB- cord-005453-4057qib7 7990 32 in in IN cord-005453-4057qib7 7990 33 ongoing ongoing JJ cord-005453-4057qib7 7990 34 prospective prospective JJ cord-005453-4057qib7 7990 35 randomized randomized JJ cord-005453-4057qib7 7990 36 multinational multinational JJ cord-005453-4057qib7 7990 37 trials trial NNS cord-005453-4057qib7 7990 38 . . . cord-005453-4057qib7 7991 1 Disclosure disclosure NN cord-005453-4057qib7 7991 2 : : : cord-005453-4057qib7 7991 3 Nothing nothing NN cord-005453-4057qib7 7991 4 to to TO cord-005453-4057qib7 7991 5 disclosure disclosure NN cord-005453-4057qib7 7991 6 Background background NN cord-005453-4057qib7 7991 7 : : : cord-005453-4057qib7 7991 8 Autologous autologous JJ cord-005453-4057qib7 7991 9 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 7991 10 Stem Stem NNP cord-005453-4057qib7 7991 11 Cell Cell NNP cord-005453-4057qib7 7991 12 Transplantation transplantation NN cord-005453-4057qib7 7991 13 ( ( -LRB- cord-005453-4057qib7 7991 14 AutoSCT AutoSCT NNP cord-005453-4057qib7 7991 15 ) ) -RRB- cord-005453-4057qib7 7991 16 for for IN cord-005453-4057qib7 7991 17 Acute Acute NNP cord-005453-4057qib7 7991 18 Myeloid Myeloid NNP cord-005453-4057qib7 7991 19 Leukaemia Leukaemia NNP cord-005453-4057qib7 7991 20 ( ( -LRB- cord-005453-4057qib7 7991 21 AML AML NNP cord-005453-4057qib7 7991 22 ) ) -RRB- cord-005453-4057qib7 7992 1 is be VBZ cord-005453-4057qib7 7992 2 increasing increase VBG cord-005453-4057qib7 7992 3 becoming become VBG cord-005453-4057qib7 7992 4 a a DT cord-005453-4057qib7 7992 5 viable viable JJ cord-005453-4057qib7 7992 6 option option NN cord-005453-4057qib7 7992 7 for for IN cord-005453-4057qib7 7992 8 an an DT cord-005453-4057qib7 7992 9 increasing increase VBG cord-005453-4057qib7 7992 10 number number NN cord-005453-4057qib7 7992 11 of of IN cord-005453-4057qib7 7992 12 patients patient NNS cord-005453-4057qib7 7992 13 due due JJ cord-005453-4057qib7 7992 14 to to IN cord-005453-4057qib7 7992 15 limited limited JJ cord-005453-4057qib7 7992 16 availability availability NN cord-005453-4057qib7 7992 17 of of IN cord-005453-4057qib7 7992 18 matched match VBN cord-005453-4057qib7 7992 19 sibling sibling NN cord-005453-4057qib7 7992 20 or or CC cord-005453-4057qib7 7992 21 unrelated unrelated JJ cord-005453-4057qib7 7992 22 donor donor NN cord-005453-4057qib7 7992 23 for for IN cord-005453-4057qib7 7992 24 Allogeneic Allogeneic NNP cord-005453-4057qib7 7992 25 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 7992 26 Stem Stem NNP cord-005453-4057qib7 7992 27 Cell cell NN cord-005453-4057qib7 7992 28 Transplantation transplantation NN cord-005453-4057qib7 7992 29 ( ( -LRB- cord-005453-4057qib7 7992 30 AlloSCT AlloSCT NNP cord-005453-4057qib7 7992 31 ) ) -RRB- cord-005453-4057qib7 7992 32 . . . cord-005453-4057qib7 7993 1 We -PRON- PRP cord-005453-4057qib7 7993 2 examined examine VBD cord-005453-4057qib7 7993 3 the the DT cord-005453-4057qib7 7993 4 relevant relevant JJ cord-005453-4057qib7 7993 5 long long JJ cord-005453-4057qib7 7993 6 - - HYPH cord-005453-4057qib7 7993 7 term term NN cord-005453-4057qib7 7993 8 outcomes outcome NNS cord-005453-4057qib7 7993 9 in in IN cord-005453-4057qib7 7993 10 our -PRON- PRP$ cord-005453-4057qib7 7993 11 local local JJ cord-005453-4057qib7 7993 12 patient patient JJ cord-005453-4057qib7 7993 13 cohort cohort NN cord-005453-4057qib7 7993 14 . . . cord-005453-4057qib7 7994 1 Methods method NNS cord-005453-4057qib7 7994 2 : : : cord-005453-4057qib7 7994 3 We -PRON- PRP cord-005453-4057qib7 7994 4 retrospectively retrospectively RB cord-005453-4057qib7 7994 5 reviewed review VBD cord-005453-4057qib7 7994 6 the the DT cord-005453-4057qib7 7994 7 data datum NNS cord-005453-4057qib7 7994 8 for for IN cord-005453-4057qib7 7994 9 all all DT cord-005453-4057qib7 7994 10 AutoSCT autosct CD cord-005453-4057qib7 7994 11 done do VBN cord-005453-4057qib7 7994 12 for for IN cord-005453-4057qib7 7994 13 AML AML NNP cord-005453-4057qib7 7994 14 in in IN cord-005453-4057qib7 7994 15 our -PRON- PRP$ cord-005453-4057qib7 7994 16 centre centre NN cord-005453-4057qib7 7994 17 over over IN cord-005453-4057qib7 7994 18 a a DT cord-005453-4057qib7 7994 19 17-years 17-years CD cord-005453-4057qib7 7994 20 period period NN cord-005453-4057qib7 7994 21 between between IN cord-005453-4057qib7 7994 22 1 1 CD cord-005453-4057qib7 7994 23 st st NNP cord-005453-4057qib7 7994 24 January January NNP cord-005453-4057qib7 7994 25 2001 2001 CD cord-005453-4057qib7 7994 26 until until IN cord-005453-4057qib7 7994 27 31 31 CD cord-005453-4057qib7 7994 28 st st NNP cord-005453-4057qib7 7994 29 Dec Dec NNP cord-005453-4057qib7 7994 30 2017 2017 CD cord-005453-4057qib7 7994 31 from from IN cord-005453-4057qib7 7994 32 our -PRON- PRP$ cord-005453-4057qib7 7994 33 electronic electronic JJ cord-005453-4057qib7 7994 34 record record NN cord-005453-4057qib7 7994 35 . . . cord-005453-4057qib7 7995 1 Patients patient NNS cord-005453-4057qib7 7995 2 with with IN cord-005453-4057qib7 7995 3 Acute acute JJ cord-005453-4057qib7 7995 4 Promyelocytic Promyelocytic NNP cord-005453-4057qib7 7995 5 Leukaemia Leukaemia NNP cord-005453-4057qib7 7995 6 ( ( -LRB- cord-005453-4057qib7 7995 7 APML APML NNP cord-005453-4057qib7 7995 8 ) ) -RRB- cord-005453-4057qib7 7995 9 were be VBD cord-005453-4057qib7 7995 10 excluded exclude VBN cord-005453-4057qib7 7995 11 from from IN cord-005453-4057qib7 7995 12 this this DT cord-005453-4057qib7 7995 13 analysis analysis NN cord-005453-4057qib7 7995 14 . . . cord-005453-4057qib7 7996 1 Patients patient NNS cord-005453-4057qib7 7996 2 were be VBD cord-005453-4057qib7 7996 3 further further RB cord-005453-4057qib7 7996 4 stratified stratify VBN cord-005453-4057qib7 7996 5 based base VBN cord-005453-4057qib7 7996 6 on on IN cord-005453-4057qib7 7996 7 the the DT cord-005453-4057qib7 7996 8 number number NN cord-005453-4057qib7 7996 9 of of IN cord-005453-4057qib7 7996 10 high high JJ cord-005453-4057qib7 7996 11 risk risk NN cord-005453-4057qib7 7996 12 features feature VBZ cord-005453-4057qib7 7996 13 present present JJ cord-005453-4057qib7 7996 14 ; ; : cord-005453-4057qib7 7996 15 not not RB cord-005453-4057qib7 7996 16 achieving achieve VBG cord-005453-4057qib7 7996 17 complete complete JJ cord-005453-4057qib7 7996 18 remission remission NN cord-005453-4057qib7 7996 19 ( ( -LRB- cord-005453-4057qib7 7996 20 CR cr NN cord-005453-4057qib7 7996 21 ) ) -RRB- cord-005453-4057qib7 7996 22 following follow VBG cord-005453-4057qib7 7996 23 induction induction NN cord-005453-4057qib7 7997 1 chemotherapy chemotherapy NN cord-005453-4057qib7 7997 2 , , , cord-005453-4057qib7 7997 3 high high RB cord-005453-4057qib7 7997 4 presenting present VBG cord-005453-4057qib7 7997 5 total total JJ cord-005453-4057qib7 7997 6 white white JJ cord-005453-4057qib7 7997 7 cell cell NN cord-005453-4057qib7 7997 8 count count NN cord-005453-4057qib7 7997 9 ( ( -LRB- cord-005453-4057qib7 7997 10 WBC WBC NNP cord-005453-4057qib7 7997 11 > > XX cord-005453-4057qib7 7998 1 100 100 CD cord-005453-4057qib7 7998 2 x x SYM cord-005453-4057qib7 7998 3 10 10 CD cord-005453-4057qib7 7998 4 6 6 CD cord-005453-4057qib7 7998 5 /ml /ml CD cord-005453-4057qib7 7998 6 , , , cord-005453-4057qib7 7998 7 adverse adverse JJ cord-005453-4057qib7 7998 8 cytogenetics cytogenetic NNS cord-005453-4057qib7 7998 9 ( ( -LRB- cord-005453-4057qib7 7998 10 example example NN cord-005453-4057qib7 7998 11 : : : cord-005453-4057qib7 7998 12 complex complex JJ cord-005453-4057qib7 7998 13 cytogenetics cytogenetic NNS cord-005453-4057qib7 7998 14 ) ) -RRB- cord-005453-4057qib7 7998 15 and and CC cord-005453-4057qib7 7998 16 adverse adverse JJ cord-005453-4057qib7 7998 17 molecular molecular JJ cord-005453-4057qib7 7998 18 mutations mutation NNS cord-005453-4057qib7 7999 1 ( ( -LRB- cord-005453-4057qib7 7999 2 example example NN cord-005453-4057qib7 7999 3 : : : cord-005453-4057qib7 7999 4 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 7999 5 & & CC cord-005453-4057qib7 7999 6 MLL MLL NNP cord-005453-4057qib7 7999 7 gene gene NN cord-005453-4057qib7 7999 8 arrangement arrangement NN cord-005453-4057qib7 7999 9 ) ) -RRB- cord-005453-4057qib7 7999 10 . . . cord-005453-4057qib7 8000 1 Outcome outcome NN cord-005453-4057qib7 8000 2 data datum NNS cord-005453-4057qib7 8000 3 including include VBG cord-005453-4057qib7 8000 4 mortality mortality NN cord-005453-4057qib7 8000 5 ( ( -LRB- cord-005453-4057qib7 8000 6 Overall overall JJ cord-005453-4057qib7 8000 7 survival survival NN cord-005453-4057qib7 8000 8 ( ( -LRB- cord-005453-4057qib7 8000 9 OS OS NNP cord-005453-4057qib7 8000 10 ) ) -RRB- cord-005453-4057qib7 8000 11 and and CC cord-005453-4057qib7 8000 12 non non JJ cord-005453-4057qib7 8000 13 - - JJ cord-005453-4057qib7 8000 14 relapse relapse JJ cord-005453-4057qib7 8000 15 mortality mortality NN cord-005453-4057qib7 8000 16 ( ( -LRB- cord-005453-4057qib7 8000 17 NRM NRM NNP cord-005453-4057qib7 8000 18 ) ) -RRB- cord-005453-4057qib7 8000 19 ) ) -RRB- cord-005453-4057qib7 8000 20 and and CC cord-005453-4057qib7 8000 21 morbidity morbidity NN cord-005453-4057qib7 8000 22 ( ( -LRB- cord-005453-4057qib7 8000 23 leukaemia leukaemia NN cord-005453-4057qib7 8000 24 free free JJ cord-005453-4057qib7 8000 25 survival survival NN cord-005453-4057qib7 8000 26 ( ( -LRB- cord-005453-4057qib7 8000 27 LFS LFS NNP cord-005453-4057qib7 8000 28 ) ) -RRB- cord-005453-4057qib7 8000 29 ) ) -RRB- cord-005453-4057qib7 8000 30 were be VBD cord-005453-4057qib7 8000 31 recorded record VBN cord-005453-4057qib7 8000 32 and and CC cord-005453-4057qib7 8000 33 analysed analyse VBN cord-005453-4057qib7 8000 34 . . . cord-005453-4057qib7 8001 1 Results result NNS cord-005453-4057qib7 8001 2 : : : cord-005453-4057qib7 8002 1 A a DT cord-005453-4057qib7 8002 2 total total NN cord-005453-4057qib7 8002 3 of of IN cord-005453-4057qib7 8002 4 64 64 CD cord-005453-4057qib7 8002 5 patients patient NNS cord-005453-4057qib7 8002 6 were be VBD cord-005453-4057qib7 8002 7 identified identify VBN cord-005453-4057qib7 8002 8 . . . cord-005453-4057qib7 8003 1 Median median JJ cord-005453-4057qib7 8003 2 age age NN cord-005453-4057qib7 8003 3 at at IN cord-005453-4057qib7 8003 4 diagnosis diagnosis NN cord-005453-4057qib7 8003 5 is be VBZ cord-005453-4057qib7 8003 6 34-years 34-years CD cord-005453-4057qib7 8003 7 old old JJ cord-005453-4057qib7 8003 8 . . . cord-005453-4057qib7 8004 1 The the DT cord-005453-4057qib7 8004 2 cohort cohort NN cord-005453-4057qib7 8004 3 comprised comprise VBN cord-005453-4057qib7 8004 4 of of IN cord-005453-4057qib7 8004 5 34 34 CD cord-005453-4057qib7 8004 6 males male NNS cord-005453-4057qib7 8004 7 and and CC cord-005453-4057qib7 8004 8 30 30 CD cord-005453-4057qib7 8004 9 females female NNS cord-005453-4057qib7 8004 10 . . . cord-005453-4057qib7 8005 1 The the DT cord-005453-4057qib7 8005 2 overall overall JJ cord-005453-4057qib7 8005 3 median median JJ cord-005453-4057qib7 8005 4 OS os NN cord-005453-4057qib7 8005 5 and and CC cord-005453-4057qib7 8005 6 median median JJ cord-005453-4057qib7 8005 7 LFS lfs NN cord-005453-4057qib7 8005 8 is be VBZ cord-005453-4057qib7 8005 9 3.9 3.9 CD cord-005453-4057qib7 8005 10 years year NNS cord-005453-4057qib7 8005 11 and and CC cord-005453-4057qib7 8005 12 2.2 2.2 CD cord-005453-4057qib7 8005 13 years year NNS cord-005453-4057qib7 8005 14 respectively respectively RB cord-005453-4057qib7 8005 15 . . . cord-005453-4057qib7 8006 1 The the DT cord-005453-4057qib7 8006 2 NRM NRM NNP cord-005453-4057qib7 8006 3 is be VBZ cord-005453-4057qib7 8006 4 1.6 1.6 CD cord-005453-4057qib7 8006 5 % % NN cord-005453-4057qib7 8006 6 ( ( -LRB- cord-005453-4057qib7 8006 7 1/64 1/64 CD cord-005453-4057qib7 8006 8 ) ) -RRB- cord-005453-4057qib7 8006 9 . . . cord-005453-4057qib7 8007 1 There there EX cord-005453-4057qib7 8007 2 was be VBD cord-005453-4057qib7 8007 3 no no DT cord-005453-4057qib7 8007 4 difference difference NN cord-005453-4057qib7 8007 5 in in IN cord-005453-4057qib7 8007 6 the the DT cord-005453-4057qib7 8007 7 median median JJ cord-005453-4057qib7 8007 8 OS os NN cord-005453-4057qib7 8007 9 and and CC cord-005453-4057qib7 8007 10 median median JJ cord-005453-4057qib7 8007 11 LFS lfs NN cord-005453-4057qib7 8007 12 for for IN cord-005453-4057qib7 8007 13 the the DT cord-005453-4057qib7 8007 14 patients patient NNS cord-005453-4057qib7 8007 15 achieving achieve VBG cord-005453-4057qib7 8007 16 CR cr NN cord-005453-4057qib7 8007 17 following follow VBG cord-005453-4057qib7 8007 18 induction induction NN cord-005453-4057qib7 8007 19 chemotherapy chemotherapy NN cord-005453-4057qib7 8007 20 and and CC cord-005453-4057qib7 8007 21 those those DT cord-005453-4057qib7 8007 22 not not RB cord-005453-4057qib7 8007 23 in in IN cord-005453-4057qib7 8007 24 CR CR NNP cord-005453-4057qib7 8007 25 following follow VBG cord-005453-4057qib7 8007 26 induction induction NN cord-005453-4057qib7 8007 27 chemotherapy chemotherapy NN cord-005453-4057qib7 8007 28 ; ; : cord-005453-4057qib7 8007 29 4.4 4.4 CD cord-005453-4057qib7 8007 30 years year NNS cord-005453-4057qib7 8007 31 versus versus IN cord-005453-4057qib7 8007 32 3.9 3.9 CD cord-005453-4057qib7 8007 33 years year NNS cord-005453-4057qib7 8007 34 ( ( -LRB- cord-005453-4057qib7 8007 35 Log log JJ cord-005453-4057qib7 8007 36 - - HYPH cord-005453-4057qib7 8007 37 rank rank NN cord-005453-4057qib7 8007 38 , , , cord-005453-4057qib7 8007 39 p=0.9 p=0.9 NNP cord-005453-4057qib7 8007 40 ) ) -RRB- cord-005453-4057qib7 8007 41 and and CC cord-005453-4057qib7 8007 42 3.4 3.4 CD cord-005453-4057qib7 8007 43 years year NNS cord-005453-4057qib7 8007 44 versus versus IN cord-005453-4057qib7 8007 45 2.1 2.1 CD cord-005453-4057qib7 8007 46 years year NNS cord-005453-4057qib7 8007 47 ( ( -LRB- cord-005453-4057qib7 8007 48 Log log JJ cord-005453-4057qib7 8007 49 - - HYPH cord-005453-4057qib7 8007 50 rank rank NN cord-005453-4057qib7 8007 51 , , , cord-005453-4057qib7 8007 52 p=0.9 p=0.9 NNP cord-005453-4057qib7 8007 53 ) ) -RRB- cord-005453-4057qib7 8007 54 respectively respectively RB cord-005453-4057qib7 8007 55 . . . cord-005453-4057qib7 8008 1 The the DT cord-005453-4057qib7 8008 2 median median JJ cord-005453-4057qib7 8008 3 OS OS NNP cord-005453-4057qib7 8008 4 were be VBD cord-005453-4057qib7 8008 5 statistically statistically RB cord-005453-4057qib7 8008 6 significant significant JJ cord-005453-4057qib7 8008 7 for for IN cord-005453-4057qib7 8008 8 patients patient NNS cord-005453-4057qib7 8008 9 with with IN cord-005453-4057qib7 8008 10 zero zero CD cord-005453-4057qib7 8008 11 versus versus IN cord-005453-4057qib7 8008 12 one one CD cord-005453-4057qib7 8008 13 and and CC cord-005453-4057qib7 8008 14 two two CD cord-005453-4057qib7 8008 15 and and CC cord-005453-4057qib7 8008 16 more more JJR cord-005453-4057qib7 8008 17 high high JJ cord-005453-4057qib7 8008 18 risk risk NN cord-005453-4057qib7 8008 19 features feature VBZ cord-005453-4057qib7 8008 20 present present JJ cord-005453-4057qib7 8008 21 ; ; : cord-005453-4057qib7 8008 22 10.2 10.2 CD cord-005453-4057qib7 8008 23 years year NNS cord-005453-4057qib7 8008 24 versus versus IN cord-005453-4057qib7 8008 25 3.7 3.7 CD cord-005453-4057qib7 8008 26 years year NNS cord-005453-4057qib7 8008 27 versus versus IN cord-005453-4057qib7 8008 28 2.2 2.2 CD cord-005453-4057qib7 8008 29 years year NNS cord-005453-4057qib7 8008 30 ( ( -LRB- cord-005453-4057qib7 8008 31 Log log JJ cord-005453-4057qib7 8008 32 - - HYPH cord-005453-4057qib7 8008 33 rank rank NN cord-005453-4057qib7 8008 34 , , , cord-005453-4057qib7 8008 35 p=0.4 p=0.4 NNP cord-005453-4057qib7 8008 36 ) ) -RRB- cord-005453-4057qib7 8008 37 respectively respectively RB cord-005453-4057qib7 8008 38 . . . cord-005453-4057qib7 8009 1 However however RB cord-005453-4057qib7 8009 2 , , , cord-005453-4057qib7 8009 3 the the DT cord-005453-4057qib7 8009 4 median median JJ cord-005453-4057qib7 8009 5 LFS lfs NN cord-005453-4057qib7 8009 6 were be VBD cord-005453-4057qib7 8009 7 not not RB cord-005453-4057qib7 8009 8 statistically statistically RB cord-005453-4057qib7 8009 9 significant significant JJ cord-005453-4057qib7 8009 10 for for IN cord-005453-4057qib7 8009 11 these these DT cord-005453-4057qib7 8009 12 three three CD cord-005453-4057qib7 8009 13 patient patient JJ cord-005453-4057qib7 8009 14 cohorts cohort NNS cord-005453-4057qib7 8009 15 ; ; : cord-005453-4057qib7 8009 16 3.6 3.6 CD cord-005453-4057qib7 8009 17 years year NNS cord-005453-4057qib7 8009 18 versus versus IN cord-005453-4057qib7 8009 19 1.9 1.9 CD cord-005453-4057qib7 8009 20 years year NNS cord-005453-4057qib7 8009 21 versus versus IN cord-005453-4057qib7 8009 22 1.4 1.4 CD cord-005453-4057qib7 8009 23 years year NNS cord-005453-4057qib7 8009 24 ( ( -LRB- cord-005453-4057qib7 8009 25 Log log JJ cord-005453-4057qib7 8009 26 - - HYPH cord-005453-4057qib7 8009 27 rank rank NN cord-005453-4057qib7 8009 28 , , , cord-005453-4057qib7 8009 29 p=0.7 p=0.7 NNP cord-005453-4057qib7 8009 30 ) ) -RRB- cord-005453-4057qib7 8009 31 respectively respectively RB cord-005453-4057qib7 8009 32 . . . cord-005453-4057qib7 8010 1 Conclusions conclusion NNS cord-005453-4057qib7 8010 2 : : : cord-005453-4057qib7 8011 1 In in IN cord-005453-4057qib7 8011 2 our -PRON- PRP$ cord-005453-4057qib7 8011 3 patient patient JJ cord-005453-4057qib7 8011 4 cohort cohort NN cord-005453-4057qib7 8011 5 , , , cord-005453-4057qib7 8011 6 AutoSCT AutoSCT NNP cord-005453-4057qib7 8011 7 appeared appear VBD cord-005453-4057qib7 8011 8 to to TO cord-005453-4057qib7 8011 9 be be VB cord-005453-4057qib7 8011 10 a a DT cord-005453-4057qib7 8011 11 feasible feasible JJ cord-005453-4057qib7 8011 12 option option NN cord-005453-4057qib7 8011 13 for for IN cord-005453-4057qib7 8011 14 patents patent NNS cord-005453-4057qib7 8011 15 with with IN cord-005453-4057qib7 8011 16 AML AML NNP cord-005453-4057qib7 8011 17 without without IN cord-005453-4057qib7 8011 18 matched match VBN cord-005453-4057qib7 8011 19 sibling sibling NN cord-005453-4057qib7 8011 20 or or CC cord-005453-4057qib7 8011 21 unrelated unrelated JJ cord-005453-4057qib7 8011 22 donor donor NN cord-005453-4057qib7 8011 23 available available JJ cord-005453-4057qib7 8011 24 . . . cord-005453-4057qib7 8012 1 Disclosure disclosure NN cord-005453-4057qib7 8012 2 : : : cord-005453-4057qib7 8012 3 None none NN cord-005453-4057qib7 8012 4 to to TO cord-005453-4057qib7 8012 5 declare declare VB cord-005453-4057qib7 8012 6 Methods method NNS cord-005453-4057qib7 8012 7 : : : cord-005453-4057qib7 8012 8 Between between IN cord-005453-4057qib7 8012 9 2014 2014 CD cord-005453-4057qib7 8012 10 - - SYM cord-005453-4057qib7 8012 11 2018 2018 CD cord-005453-4057qib7 8012 12 , , , cord-005453-4057qib7 8012 13 16 16 CD cord-005453-4057qib7 8012 14 thalassemic thalassemic NNP cord-005453-4057qib7 8012 15 patientsunderwent patientsunderwent NN cord-005453-4057qib7 8012 16 HISCT HISCT NNP cord-005453-4057qib7 8012 17 . . . cord-005453-4057qib7 8013 1 The the DT cord-005453-4057qib7 8013 2 median median JJ cord-005453-4057qib7 8013 3 age age NN cord-005453-4057qib7 8013 4 of of IN cord-005453-4057qib7 8013 5 patients patient NNS cord-005453-4057qib7 8013 6 was5 was5 NNS cord-005453-4057qib7 8013 7 ( ( -LRB- cord-005453-4057qib7 8013 8 1 1 CD cord-005453-4057qib7 8013 9 - - SYM cord-005453-4057qib7 8013 10 8)years 8)years CD cord-005453-4057qib7 8013 11 with with IN cord-005453-4057qib7 8013 12 male male JJ cord-005453-4057qib7 8013 13 preponderance preponderance NN cord-005453-4057qib7 8013 14 ( ( -LRB- cord-005453-4057qib7 8013 15 n=10 n=10 NNP cord-005453-4057qib7 8013 16 , , , cord-005453-4057qib7 8013 17 62.5 62.5 CD cord-005453-4057qib7 8013 18 % % NN cord-005453-4057qib7 8013 19 ) ) -RRB- cord-005453-4057qib7 8013 20 . . . cord-005453-4057qib7 8014 1 Across across IN cord-005453-4057qib7 8014 2 the the DT cord-005453-4057qib7 8014 3 gender gender NN cord-005453-4057qib7 8014 4 and and CC cord-005453-4057qib7 8014 5 ABO ABO NNP cord-005453-4057qib7 8014 6 mismatch mismatch NN cord-005453-4057qib7 8014 7 transplants transplant NNS cord-005453-4057qib7 8014 8 were be VBD cord-005453-4057qib7 8014 9 done do VBN cord-005453-4057qib7 8014 10 in in IN cord-005453-4057qib7 8014 11 43.7 43.7 CD cord-005453-4057qib7 8014 12 % % NN cord-005453-4057qib7 8014 13 and and CC cord-005453-4057qib7 8014 14 25 25 CD cord-005453-4057qib7 8014 15 % % NN cord-005453-4057qib7 8014 16 of of IN cord-005453-4057qib7 8014 17 patients patient NNS cord-005453-4057qib7 8014 18 . . . cord-005453-4057qib7 8015 1 Stem stem JJ cord-005453-4057qib7 8015 2 cell cell NN cord-005453-4057qib7 8015 3 source source NN cord-005453-4057qib7 8015 4 was be VBD cord-005453-4057qib7 8015 5 bone bone NN cord-005453-4057qib7 8015 6 marrow marrow NN cord-005453-4057qib7 8015 7 in in IN cord-005453-4057qib7 8015 8 5 5 CD cord-005453-4057qib7 8015 9 ( ( -LRB- cord-005453-4057qib7 8015 10 31 31 CD cord-005453-4057qib7 8015 11 % % NN cord-005453-4057qib7 8015 12 ) ) -RRB- cord-005453-4057qib7 8015 13 while while IN cord-005453-4057qib7 8015 14 peripheral peripheral JJ cord-005453-4057qib7 8015 15 blood blood NN cord-005453-4057qib7 8015 16 in in IN cord-005453-4057qib7 8015 17 11 11 CD cord-005453-4057qib7 8015 18 ( ( -LRB- cord-005453-4057qib7 8015 19 69 69 CD cord-005453-4057qib7 8015 20 % % NN cord-005453-4057qib7 8015 21 ) ) -RRB- cord-005453-4057qib7 8015 22 of of IN cord-005453-4057qib7 8015 23 patients patient NNS cord-005453-4057qib7 8015 24 . . . cord-005453-4057qib7 8016 1 Mean mean JJ cord-005453-4057qib7 8016 2 stem stem NN cord-005453-4057qib7 8016 3 cell cell NN cord-005453-4057qib7 8016 4 dose dose NN cord-005453-4057qib7 8016 5 was be VBD cord-005453-4057qib7 8017 1 5.6 5.6 CD cord-005453-4057qib7 8017 2 ± ± CD cord-005453-4057qib7 8017 3 2.9 2.9 CD cord-005453-4057qib7 8017 4 x x SYM cord-005453-4057qib7 8017 5 10 10 CD cord-005453-4057qib7 8017 6 6 6 CD cord-005453-4057qib7 8017 7 cells cell NNS cord-005453-4057qib7 8017 8 / / SYM cord-005453-4057qib7 8017 9 kg kg NNS cord-005453-4057qib7 8017 10 and and CC cord-005453-4057qib7 8017 11 mean mean VB cord-005453-4057qib7 8017 12 volume volume NN cord-005453-4057qib7 8017 13 of of IN cord-005453-4057qib7 8017 14 product product NN cord-005453-4057qib7 8017 15 was be VBD cord-005453-4057qib7 8017 16 188 188 CD cord-005453-4057qib7 8017 17 ± ± CD cord-005453-4057qib7 8017 18 60.58 60.58 CD cord-005453-4057qib7 8017 19 ml ml NN cord-005453-4057qib7 8017 20 . . . cord-005453-4057qib7 8018 1 Preparative preparative JJ cord-005453-4057qib7 8018 2 regimen regimen NN cord-005453-4057qib7 8018 3 included include VBD cord-005453-4057qib7 8018 4 Anti Anti NNP cord-005453-4057qib7 8018 5 - - JJ cord-005453-4057qib7 8018 6 thymocyte thymocyte JJ cord-005453-4057qib7 8018 7 globulin globulin NN cord-005453-4057qib7 8018 8 , , , cord-005453-4057qib7 8018 9 Busulfan Busulfan NNP cord-005453-4057qib7 8018 10 , , , cord-005453-4057qib7 8018 11 Fludarabine Fludarabine NNP cord-005453-4057qib7 8018 12 and and CC cord-005453-4057qib7 8018 13 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 8018 14 . . . cord-005453-4057qib7 8019 1 Graft graft NN cord-005453-4057qib7 8019 2 versus versus IN cord-005453-4057qib7 8019 3 host host NN cord-005453-4057qib7 8019 4 disease disease NN cord-005453-4057qib7 8019 5 ( ( -LRB- cord-005453-4057qib7 8019 6 GvHD GvHD NNP cord-005453-4057qib7 8019 7 ) ) -RRB- cord-005453-4057qib7 8019 8 prophylaxis prophylaxis NN cord-005453-4057qib7 8019 9 comprised comprise VBN cord-005453-4057qib7 8019 10 of of IN cord-005453-4057qib7 8019 11 posttransplant posttransplant NNP cord-005453-4057qib7 8019 12 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 8019 13 on on IN cord-005453-4057qib7 8019 14 day day NN cord-005453-4057qib7 8019 15 +3 +3 NNP cord-005453-4057qib7 8019 16 & & CC cord-005453-4057qib7 8019 17 +4 +4 NNP cord-005453-4057qib7 8019 18 followed follow VBN cord-005453-4057qib7 8019 19 by by IN cord-005453-4057qib7 8019 20 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 8019 21 and and CC cord-005453-4057qib7 8019 22 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 8019 23 mofetil mofetil NNP cord-005453-4057qib7 8019 24 . . . cord-005453-4057qib7 8020 1 Patients patient NNS cord-005453-4057qib7 8020 2 were be VBD cord-005453-4057qib7 8020 3 observed observe VBN cord-005453-4057qib7 8020 4 for for IN cord-005453-4057qib7 8020 5 hematopoietic hematopoietic JJ cord-005453-4057qib7 8020 6 recovery recovery NN cord-005453-4057qib7 8020 7 ( ( -LRB- cord-005453-4057qib7 8020 8 neutrophil neutrophil NN cord-005453-4057qib7 8020 9 and and CC cord-005453-4057qib7 8020 10 platelet platelet NN cord-005453-4057qib7 8020 11 engraftment engraftment NN cord-005453-4057qib7 8020 12 ) ) -RRB- cord-005453-4057qib7 8020 13 and and CC cord-005453-4057qib7 8020 14 transplant transplant NN cord-005453-4057qib7 8020 15 related relate VBN cord-005453-4057qib7 8020 16 mortality mortality NN cord-005453-4057qib7 8020 17 including include VBG cord-005453-4057qib7 8020 18 acute acute JJ cord-005453-4057qib7 8020 19 and and CC cord-005453-4057qib7 8020 20 chronic chronic JJ cord-005453-4057qib7 8020 21 GVHD GVHD NNP cord-005453-4057qib7 8020 22 for for IN cord-005453-4057qib7 8020 23 skin skin NN cord-005453-4057qib7 8020 24 , , , cord-005453-4057qib7 8020 25 gut gut NN cord-005453-4057qib7 8020 26 , , , cord-005453-4057qib7 8020 27 liverand liverand JJ cord-005453-4057qib7 8020 28 lungs lung NNS cord-005453-4057qib7 8020 29 , , , cord-005453-4057qib7 8020 30 primary primary JJ cord-005453-4057qib7 8020 31 and and CC cord-005453-4057qib7 8020 32 secondary secondary JJ cord-005453-4057qib7 8020 33 graft graft NN cord-005453-4057qib7 8020 34 failure failure NN cord-005453-4057qib7 8020 35 and and CC cord-005453-4057qib7 8020 36 infectious infectious JJ cord-005453-4057qib7 8020 37 complications complication NNS cord-005453-4057qib7 8020 38 . . . cord-005453-4057qib7 8021 1 Results result NNS cord-005453-4057qib7 8021 2 : : : cord-005453-4057qib7 8021 3 Nine(56.25 nine(56.25 CD cord-005453-4057qib7 8021 4 % % NN cord-005453-4057qib7 8021 5 ) ) -RRB- cord-005453-4057qib7 8021 6 of of IN cord-005453-4057qib7 8021 7 sixteenpatients sixteenpatient NNS cord-005453-4057qib7 8021 8 were be VBD cord-005453-4057qib7 8021 9 engrafted engraft VBN cord-005453-4057qib7 8021 10 with with IN cord-005453-4057qib7 8021 11 full full JJ cord-005453-4057qib7 8021 12 donor donor NN cord-005453-4057qib7 8021 13 chimerism chimerism NN cord-005453-4057qib7 8021 14 . . . cord-005453-4057qib7 8022 1 Twelve twelve CD cord-005453-4057qib7 8022 2 ( ( -LRB- cord-005453-4057qib7 8022 3 75 75 CD cord-005453-4057qib7 8022 4 % % NN cord-005453-4057qib7 8022 5 ) ) -RRB- cord-005453-4057qib7 8022 6 patients patient NNS cord-005453-4057qib7 8022 7 belonged belong VBD cord-005453-4057qib7 8022 8 to to IN cord-005453-4057qib7 8022 9 Pesaro Pesaro NNP cord-005453-4057qib7 8022 10 class class NN cord-005453-4057qib7 8022 11 I i NN cord-005453-4057qib7 8022 12 and and CC cord-005453-4057qib7 8022 13 4 4 CD cord-005453-4057qib7 8022 14 ( ( -LRB- cord-005453-4057qib7 8022 15 25 25 CD cord-005453-4057qib7 8022 16 % % NN cord-005453-4057qib7 8022 17 ) ) -RRB- cord-005453-4057qib7 8022 18 toClass toClass NNP cord-005453-4057qib7 8022 19 II ii CD cord-005453-4057qib7 8022 20 patients patient NNS cord-005453-4057qib7 8022 21 . . . cord-005453-4057qib7 8023 1 Median median JJ cord-005453-4057qib7 8023 2 time time NN cord-005453-4057qib7 8023 3 to to IN cord-005453-4057qib7 8023 4 neutrophil neutrophil NN cord-005453-4057qib7 8023 5 and and CC cord-005453-4057qib7 8023 6 plateletengraftment plateletengraftment NN cord-005453-4057qib7 8024 1 were13(11 were13(11 CD cord-005453-4057qib7 8024 2 - - SYM cord-005453-4057qib7 8024 3 20 20 CD cord-005453-4057qib7 8024 4 ) ) -RRB- cord-005453-4057qib7 8024 5 and16(12 and16(12 NNP cord-005453-4057qib7 8024 6 - - HYPH cord-005453-4057qib7 8024 7 36)days 36)days CD cord-005453-4057qib7 8024 8 respectively respectively RB cord-005453-4057qib7 8024 9 . . . cord-005453-4057qib7 8025 1 Average average JJ cord-005453-4057qib7 8025 2 number number NN cord-005453-4057qib7 8025 3 of of IN cord-005453-4057qib7 8025 4 packed pack VBN cord-005453-4057qib7 8025 5 red red JJ cord-005453-4057qib7 8025 6 cell cell NN cord-005453-4057qib7 8025 7 and and CC cord-005453-4057qib7 8025 8 platelet platelet NN cord-005453-4057qib7 8025 9 transfusions transfusion NNS cord-005453-4057qib7 8025 10 were be VBD cord-005453-4057qib7 8025 11 4.35±7.54 4.35±7.54 CD cord-005453-4057qib7 8025 12 and and CC cord-005453-4057qib7 8025 13 20.8 20.8 CD cord-005453-4057qib7 8025 14 ±19.18 ±19.18 XX cord-005453-4057qib7 8025 15 respectively respectively RB cord-005453-4057qib7 8025 16 . . . cord-005453-4057qib7 8026 1 Primary primary JJ cord-005453-4057qib7 8026 2 graft graft NN cord-005453-4057qib7 8026 3 failure failure NN cord-005453-4057qib7 8026 4 was be VBD cord-005453-4057qib7 8026 5 observed observe VBN cord-005453-4057qib7 8026 6 in in IN cord-005453-4057qib7 8026 7 3 3 CD cord-005453-4057qib7 8026 8 ( ( -LRB- cord-005453-4057qib7 8026 9 19 19 CD cord-005453-4057qib7 8026 10 % % NN cord-005453-4057qib7 8026 11 ) ) -RRB- cord-005453-4057qib7 8026 12 and and CC cord-005453-4057qib7 8026 13 secondary secondary JJ cord-005453-4057qib7 8026 14 graft graft NN cord-005453-4057qib7 8026 15 failure failure NN cord-005453-4057qib7 8026 16 was be VBD cord-005453-4057qib7 8026 17 observed observe VBN cord-005453-4057qib7 8026 18 in in IN cord-005453-4057qib7 8026 19 4 4 CD cord-005453-4057qib7 8026 20 ( ( -LRB- cord-005453-4057qib7 8026 21 25 25 CD cord-005453-4057qib7 8026 22 % % NN cord-005453-4057qib7 8026 23 ) ) -RRB- cord-005453-4057qib7 8026 24 patients patient NNS cord-005453-4057qib7 8026 25 . . . cord-005453-4057qib7 8027 1 Two two CD cord-005453-4057qib7 8027 2 patients patient NNS cord-005453-4057qib7 8027 3 received receive VBD cord-005453-4057qib7 8027 4 a a DT cord-005453-4057qib7 8027 5 second second JJ cord-005453-4057qib7 8027 6 dose dose NN cord-005453-4057qib7 8027 7 of of IN cord-005453-4057qib7 8027 8 stem stem NN cord-005453-4057qib7 8027 9 cells cell NNS cord-005453-4057qib7 8027 10 and and CC cord-005453-4057qib7 8027 11 they -PRON- PRP cord-005453-4057qib7 8027 12 engrafted engraft VBD cord-005453-4057qib7 8027 13 at at IN cord-005453-4057qib7 8027 14 20and 20and CD cord-005453-4057qib7 8027 15 32 32 CD cord-005453-4057qib7 8027 16 days day NNS cord-005453-4057qib7 8027 17 of of IN cord-005453-4057qib7 8027 18 infusion infusion NN cord-005453-4057qib7 8027 19 respectively.2 respectively.2 NN cord-005453-4057qib7 8027 20 of of IN cord-005453-4057qib7 8027 21 3 3 CD cord-005453-4057qib7 8027 22 patients patient NNS cord-005453-4057qib7 8027 23 with with IN cord-005453-4057qib7 8027 24 primary primary JJ cord-005453-4057qib7 8027 25 graft graft NN cord-005453-4057qib7 8027 26 failure failure NN cord-005453-4057qib7 8027 27 died die VBD cord-005453-4057qib7 8027 28 , , , cord-005453-4057qib7 8027 29 one one CD cord-005453-4057qib7 8027 30 with with IN cord-005453-4057qib7 8027 31 sepsis sepsis NN cord-005453-4057qib7 8027 32 ( ( -LRB- cord-005453-4057qib7 8027 33 day day NN cord-005453-4057qib7 8027 34 +23 +23 CD cord-005453-4057qib7 8027 35 ) ) -RRB- cord-005453-4057qib7 8027 36 and and CC cord-005453-4057qib7 8027 37 the the DT cord-005453-4057qib7 8027 38 other other JJ cord-005453-4057qib7 8027 39 because because IN cord-005453-4057qib7 8027 40 of of IN cord-005453-4057qib7 8027 41 intracranial intracranial JJ cord-005453-4057qib7 8027 42 bleeding bleeding NN cord-005453-4057qib7 8027 43 ( ( -LRB- cord-005453-4057qib7 8028 1 day day NNP cord-005453-4057qib7 8028 2 +21).Acute +21).acute JJ cord-005453-4057qib7 8029 1 GvHDof GvHDof NFP cord-005453-4057qib7 8029 2 gut gut NN cord-005453-4057qib7 8029 3 and and CC cord-005453-4057qib7 8029 4 skin skin NN cord-005453-4057qib7 8029 5 ( ( -LRB- cord-005453-4057qib7 8029 6 grade grade NN cord-005453-4057qib7 8029 7 II II NNP cord-005453-4057qib7 8029 8 - - HYPH cord-005453-4057qib7 8029 9 III III NNP cord-005453-4057qib7 8029 10 ) ) -RRB- cord-005453-4057qib7 8029 11 was be VBD cord-005453-4057qib7 8029 12 observed observe VBN cord-005453-4057qib7 8029 13 in in IN cord-005453-4057qib7 8029 14 2 2 CD cord-005453-4057qib7 8029 15 patients patient NNS cord-005453-4057qib7 8029 16 each each DT cord-005453-4057qib7 8029 17 , , , cord-005453-4057qib7 8029 18 within within IN cord-005453-4057qib7 8029 19 first first JJ cord-005453-4057qib7 8029 20 100 100 CD cord-005453-4057qib7 8029 21 days day NNS cord-005453-4057qib7 8029 22 post post NN cord-005453-4057qib7 8029 23 - - NN cord-005453-4057qib7 8029 24 transplant transplant NN cord-005453-4057qib7 8029 25 . . . cord-005453-4057qib7 8030 1 None none NN cord-005453-4057qib7 8030 2 of of IN cord-005453-4057qib7 8030 3 the the DT cord-005453-4057qib7 8030 4 patients patient NNS cord-005453-4057qib7 8030 5 had have VBD cord-005453-4057qib7 8030 6 grade grade NN cord-005453-4057qib7 8030 7 IV IV NNP cord-005453-4057qib7 8030 8 GvHD GvHD NNP cord-005453-4057qib7 8030 9 . . . cord-005453-4057qib7 8031 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 8031 2 reactivation reactivation NN cord-005453-4057qib7 8031 3 occurred occur VBD cord-005453-4057qib7 8031 4 in in IN cord-005453-4057qib7 8031 5 50 50 CD cord-005453-4057qib7 8031 6 % % NN cord-005453-4057qib7 8031 7 of of IN cord-005453-4057qib7 8031 8 patients patient NNS cord-005453-4057qib7 8031 9 , , , cord-005453-4057qib7 8031 10 all all DT cord-005453-4057qib7 8031 11 of of IN cord-005453-4057qib7 8031 12 them -PRON- PRP cord-005453-4057qib7 8031 13 received receive VBD cord-005453-4057qib7 8031 14 pre pre JJ cord-005453-4057qib7 8031 15 - - JJ cord-005453-4057qib7 8031 16 emptive emptive JJ cord-005453-4057qib7 8031 17 therapy therapy NN cord-005453-4057qib7 8031 18 with with IN cord-005453-4057qib7 8031 19 intravenous intravenous JJ cord-005453-4057qib7 8031 20 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 8031 21 . . . cord-005453-4057qib7 8032 1 None none NN cord-005453-4057qib7 8032 2 of of IN cord-005453-4057qib7 8032 3 them -PRON- PRP cord-005453-4057qib7 8032 4 developed develop VBD cord-005453-4057qib7 8032 5 CMV CMV NNP cord-005453-4057qib7 8032 6 disease disease NN cord-005453-4057qib7 8032 7 . . . cord-005453-4057qib7 8033 1 Invasive invasive JJ cord-005453-4057qib7 8033 2 fungal fungal NN cord-005453-4057qib7 8033 3 infection infection NN cord-005453-4057qib7 8033 4 was be VBD cord-005453-4057qib7 8033 5 not not RB cord-005453-4057qib7 8033 6 observed observe VBN cord-005453-4057qib7 8033 7 in in IN cord-005453-4057qib7 8033 8 any any DT cord-005453-4057qib7 8033 9 of of IN cord-005453-4057qib7 8033 10 the the DT cord-005453-4057qib7 8033 11 patient patient NN cord-005453-4057qib7 8033 12 . . . cord-005453-4057qib7 8034 1 Culture culture NN cord-005453-4057qib7 8034 2 proven prove VBN cord-005453-4057qib7 8034 3 bacterialinfection bacterialinfection NN cord-005453-4057qib7 8034 4 was be VBD cord-005453-4057qib7 8034 5 documented document VBN cord-005453-4057qib7 8034 6 in in IN cord-005453-4057qib7 8034 7 62 62 CD cord-005453-4057qib7 8034 8 % % NN cord-005453-4057qib7 8034 9 of of IN cord-005453-4057qib7 8034 10 patients patient NNS cord-005453-4057qib7 8034 11 requiring require VBG cord-005453-4057qib7 8034 12 intravenous intravenous JJ cord-005453-4057qib7 8034 13 antibiotics antibiotic NNS cord-005453-4057qib7 8034 14 during during IN cord-005453-4057qib7 8034 15 first first JJ cord-005453-4057qib7 8034 16 100 100 CD cord-005453-4057qib7 8034 17 days day NNS cord-005453-4057qib7 8034 18 post post NN cord-005453-4057qib7 8034 19 - - NN cord-005453-4057qib7 8034 20 transplant transplant NN cord-005453-4057qib7 8034 21 . . . cord-005453-4057qib7 8035 1 Overall overall JJ cord-005453-4057qib7 8035 2 survival survival NN cord-005453-4057qib7 8035 3 and and CC cord-005453-4057qib7 8035 4 relapse relapse VB cord-005453-4057qib7 8035 5 free free JJ cord-005453-4057qib7 8035 6 survival survival NN cord-005453-4057qib7 8035 7 were be VBD cord-005453-4057qib7 8035 8 81.25 81.25 CD cord-005453-4057qib7 8035 9 % % NN cord-005453-4057qib7 8035 10 and and CC cord-005453-4057qib7 8035 11 56.25 56.25 CD cord-005453-4057qib7 8035 12 % % NN cord-005453-4057qib7 8035 13 over over IN cord-005453-4057qib7 8035 14 a a DT cord-005453-4057qib7 8035 15 median median JJ cord-005453-4057qib7 8035 16 follow follow NN cord-005453-4057qib7 8035 17 - - HYPH cord-005453-4057qib7 8035 18 up up NN cord-005453-4057qib7 8035 19 of of IN cord-005453-4057qib7 8035 20 500 500 CD cord-005453-4057qib7 8035 21 ( ( -LRB- cord-005453-4057qib7 8035 22 21 21 CD cord-005453-4057qib7 8035 23 - - SYM cord-005453-4057qib7 8035 24 1757 1757 CD cord-005453-4057qib7 8035 25 ) ) -RRB- cord-005453-4057qib7 8035 26 days day NNS cord-005453-4057qib7 8035 27 . . . cord-005453-4057qib7 8036 1 Conclusions conclusion NNS cord-005453-4057qib7 8036 2 : : : cord-005453-4057qib7 8037 1 Haploidentical haploidentical JJ cord-005453-4057qib7 8037 2 transplant transplant NN cord-005453-4057qib7 8037 3 is be VBZ cord-005453-4057qib7 8037 4 a a DT cord-005453-4057qib7 8037 5 suitable suitable JJ cord-005453-4057qib7 8037 6 modality modality NN cord-005453-4057qib7 8037 7 for for IN cord-005453-4057qib7 8037 8 thalassemic thalassemic NN cord-005453-4057qib7 8037 9 patients patient NNS cord-005453-4057qib7 8037 10 lacking lack VBG cord-005453-4057qib7 8037 11 a a DT cord-005453-4057qib7 8037 12 full full JJ cord-005453-4057qib7 8037 13 matched match VBN cord-005453-4057qib7 8037 14 donor donor NN cord-005453-4057qib7 8037 15 in in IN cord-005453-4057qib7 8037 16 Pakistan Pakistan NNP cord-005453-4057qib7 8037 17 . . . cord-005453-4057qib7 8038 1 In in IN cord-005453-4057qib7 8038 2 view view NN cord-005453-4057qib7 8038 3 of of IN cord-005453-4057qib7 8038 4 our -PRON- PRP$ cord-005453-4057qib7 8038 5 results result NNS cord-005453-4057qib7 8038 6 , , , cord-005453-4057qib7 8038 7 we -PRON- PRP cord-005453-4057qib7 8038 8 suggest suggest VBP cord-005453-4057qib7 8038 9 that that IN cord-005453-4057qib7 8038 10 thalassemia thalassemia NN cord-005453-4057qib7 8038 11 patients patient NNS cord-005453-4057qib7 8038 12 should should MD cord-005453-4057qib7 8038 13 be be VB cord-005453-4057qib7 8038 14 offered offer VBN cord-005453-4057qib7 8038 15 HISCTas HISCTas NNP cord-005453-4057qib7 8038 16 an an DT cord-005453-4057qib7 8038 17 option option NN cord-005453-4057qib7 8038 18 for for IN cord-005453-4057qib7 8038 19 cure cure NN cord-005453-4057qib7 8038 20 . . . cord-005453-4057qib7 8039 1 Clinical clinical JJ cord-005453-4057qib7 8039 2 Background background NN cord-005453-4057qib7 8039 3 : : : cord-005453-4057qib7 8040 1 Gemtuzumab gemtuzumab JJ cord-005453-4057qib7 8040 2 ozogamicin ozogamicin NNS cord-005453-4057qib7 8040 3 ( ( -LRB- cord-005453-4057qib7 8040 4 GO GO NNP cord-005453-4057qib7 8040 5 ) ) -RRB- cord-005453-4057qib7 8040 6 is be VBZ cord-005453-4057qib7 8040 7 an an DT cord-005453-4057qib7 8040 8 anti anti JJ cord-005453-4057qib7 8040 9 - - JJ cord-005453-4057qib7 8040 10 CD33 CD33 NNP cord-005453-4057qib7 8040 11 monoclonal monoclonal JJ cord-005453-4057qib7 8040 12 antibody antibody NN cord-005453-4057qib7 8040 13 with with IN cord-005453-4057qib7 8040 14 significant significant JJ cord-005453-4057qib7 8040 15 activity activity NN cord-005453-4057qib7 8040 16 in in IN cord-005453-4057qib7 8040 17 de de NNP cord-005453-4057qib7 8040 18 novo novo NNP cord-005453-4057qib7 8040 19 and and CC cord-005453-4057qib7 8040 20 relapsed relapse VBD cord-005453-4057qib7 8040 21 / / SYM cord-005453-4057qib7 8040 22 refractory refractory JJ cord-005453-4057qib7 8040 23 ( ( -LRB- cord-005453-4057qib7 8040 24 R r NN cord-005453-4057qib7 8040 25 / / SYM cord-005453-4057qib7 8040 26 R r NN cord-005453-4057qib7 8040 27 ) ) -RRB- cord-005453-4057qib7 8040 28 acute acute JJ cord-005453-4057qib7 8040 29 myeloid myeloid NN cord-005453-4057qib7 8040 30 leukemia leukemia NN cord-005453-4057qib7 8040 31 ( ( -LRB- cord-005453-4057qib7 8040 32 AML AML NNP cord-005453-4057qib7 8040 33 ) ) -RRB- cord-005453-4057qib7 8040 34 . . . cord-005453-4057qib7 8041 1 A a DT cord-005453-4057qib7 8041 2 relevant relevant JJ cord-005453-4057qib7 8041 3 side side NN cord-005453-4057qib7 8041 4 effect effect NN cord-005453-4057qib7 8041 5 consists consist VBZ cord-005453-4057qib7 8041 6 of of IN cord-005453-4057qib7 8041 7 hepatotoxicity hepatotoxicity NN cord-005453-4057qib7 8041 8 and and CC cord-005453-4057qib7 8041 9 especially especially RB cord-005453-4057qib7 8041 10 sinusoidal sinusoidal JJ cord-005453-4057qib7 8041 11 obstruction obstruction NN cord-005453-4057qib7 8041 12 syndrome syndrome NN cord-005453-4057qib7 8041 13 ( ( -LRB- cord-005453-4057qib7 8041 14 SOS SOS NNP cord-005453-4057qib7 8041 15 ) ) -RRB- cord-005453-4057qib7 8041 16 . . . cord-005453-4057qib7 8042 1 The the DT cord-005453-4057qib7 8042 2 objective objective NN cord-005453-4057qib7 8042 3 of of IN cord-005453-4057qib7 8042 4 this this DT cord-005453-4057qib7 8042 5 study study NN cord-005453-4057qib7 8042 6 was be VBD cord-005453-4057qib7 8042 7 to to TO cord-005453-4057qib7 8042 8 analyze analyze VB cord-005453-4057qib7 8042 9 tolerability tolerability NN cord-005453-4057qib7 8042 10 of of IN cord-005453-4057qib7 8042 11 GO GO NNP cord-005453-4057qib7 8042 12 during during IN cord-005453-4057qib7 8042 13 the the DT cord-005453-4057qib7 8042 14 induction induction NN cord-005453-4057qib7 8042 15 and and CC cord-005453-4057qib7 8042 16 reinduction reinduction NN cord-005453-4057qib7 8042 17 therapy therapy NN cord-005453-4057qib7 8042 18 in in IN cord-005453-4057qib7 8042 19 patients patient NNS cord-005453-4057qib7 8042 20 with with IN cord-005453-4057qib7 8042 21 AML AML NNP cord-005453-4057qib7 8042 22 , , , cord-005453-4057qib7 8042 23 and and CC cord-005453-4057qib7 8042 24 its -PRON- PRP$ cord-005453-4057qib7 8042 25 possible possible JJ cord-005453-4057qib7 8042 26 impact impact NN cord-005453-4057qib7 8042 27 on on IN cord-005453-4057qib7 8042 28 subsequent subsequent JJ cord-005453-4057qib7 8042 29 hematopoietic hematopoietic JJ cord-005453-4057qib7 8042 30 stem stem NN cord-005453-4057qib7 8042 31 cell cell NN cord-005453-4057qib7 8042 32 transplantation transplantation NN cord-005453-4057qib7 8042 33 ( ( -LRB- cord-005453-4057qib7 8042 34 HSCT HSCT NNP cord-005453-4057qib7 8042 35 ) ) -RRB- cord-005453-4057qib7 8042 36 . . . cord-005453-4057qib7 8043 1 Methods method NNS cord-005453-4057qib7 8043 2 : : : cord-005453-4057qib7 8043 3 From from IN cord-005453-4057qib7 8043 4 2004 2004 CD cord-005453-4057qib7 8043 5 to to IN cord-005453-4057qib7 8043 6 2017 2017 CD cord-005453-4057qib7 8043 7 , , , cord-005453-4057qib7 8043 8 24 24 CD cord-005453-4057qib7 8043 9 patients patient NNS cord-005453-4057qib7 8043 10 who who WP cord-005453-4057qib7 8043 11 had have VBD cord-005453-4057qib7 8043 12 received receive VBN cord-005453-4057qib7 8043 13 GO GO NNP cord-005453-4057qib7 8043 14 in in IN cord-005453-4057qib7 8043 15 three three CD cord-005453-4057qib7 8043 16 hospitals hospital NNS cord-005453-4057qib7 8043 17 were be VBD cord-005453-4057qib7 8043 18 collected collect VBN cord-005453-4057qib7 8043 19 and and CC cord-005453-4057qib7 8043 20 their -PRON- PRP$ cord-005453-4057qib7 8043 21 medical medical JJ cord-005453-4057qib7 8043 22 records record NNS cord-005453-4057qib7 8043 23 were be VBD cord-005453-4057qib7 8043 24 retrospectively retrospectively RB cord-005453-4057qib7 8043 25 reviewed review VBN cord-005453-4057qib7 8043 26 . . . cord-005453-4057qib7 8044 1 Results result NNS cord-005453-4057qib7 8044 2 : : : cord-005453-4057qib7 8045 1 Fourteen fourteen CD cord-005453-4057qib7 8045 2 patients patient NNS cord-005453-4057qib7 8045 3 diagnosed diagnose VBN cord-005453-4057qib7 8045 4 with with IN cord-005453-4057qib7 8045 5 de de NNP cord-005453-4057qib7 8045 6 novo novo NNP cord-005453-4057qib7 8045 7 AML AML NNP cord-005453-4057qib7 8045 8 received receive VBD cord-005453-4057qib7 8045 9 GO GO NNP cord-005453-4057qib7 8045 10 ( ( -LRB- cord-005453-4057qib7 8045 11 3mg 3mg NNP cord-005453-4057qib7 8045 12 / / SYM cord-005453-4057qib7 8045 13 m m NN cord-005453-4057qib7 8045 14 2 2 CD cord-005453-4057qib7 8045 15 ) ) -RRB- cord-005453-4057qib7 8045 16 on on IN cord-005453-4057qib7 8045 17 day day NN cord-005453-4057qib7 8045 18 +1 +1 -RRB- cord-005453-4057qib7 8045 19 in in IN cord-005453-4057qib7 8045 20 combination combination NN cord-005453-4057qib7 8045 21 with with IN cord-005453-4057qib7 8045 22 standard standard JJ cord-005453-4057qib7 8045 23 chemotherapy chemotherapy NN cord-005453-4057qib7 8045 24 ( ( -LRB- cord-005453-4057qib7 8045 25 idarubicin idarubicin NNS cord-005453-4057qib7 8045 26 and and CC cord-005453-4057qib7 8045 27 cytarabine cytarabine NN cord-005453-4057qib7 8045 28 , , , cord-005453-4057qib7 8045 29 3x7 3x7 CD cord-005453-4057qib7 8045 30 schedule schedule NN cord-005453-4057qib7 8045 31 ) ) -RRB- cord-005453-4057qib7 8045 32 as as IN cord-005453-4057qib7 8045 33 induction induction NN cord-005453-4057qib7 8045 34 therapy therapy NN cord-005453-4057qib7 8045 35 . . . cord-005453-4057qib7 8046 1 Hyperbilirubinemia Hyperbilirubinemia NNP cord-005453-4057qib7 8047 1 ( ( -LRB- cord-005453-4057qib7 8047 2 bilirubin bilirubin NN cord-005453-4057qib7 8047 3 > > XX cord-005453-4057qib7 8047 4 1.5 1.5 CD cord-005453-4057qib7 8047 5 UNL UNL NNP cord-005453-4057qib7 8047 6 ) ) -RRB- cord-005453-4057qib7 8047 7 was be VBD cord-005453-4057qib7 8047 8 detected detect VBN cord-005453-4057qib7 8047 9 in in IN cord-005453-4057qib7 8047 10 4 4 CD cord-005453-4057qib7 8047 11 patients patient NNS cord-005453-4057qib7 8047 12 and and CC cord-005453-4057qib7 8047 13 increase increase NN cord-005453-4057qib7 8047 14 of of IN cord-005453-4057qib7 8047 15 aspartate aspartate NN cord-005453-4057qib7 8047 16 aminotransferase aminotransferase NN cord-005453-4057qib7 8047 17 ( ( -LRB- cord-005453-4057qib7 8047 18 AST AST NNP cord-005453-4057qib7 8047 19 ) ) -RRB- cord-005453-4057qib7 8047 20 ( ( -LRB- cord-005453-4057qib7 8047 21 > > NFP cord-005453-4057qib7 8047 22 2.5 2.5 CD cord-005453-4057qib7 8047 23 UNL UNL NNP cord-005453-4057qib7 8047 24 ) ) -RRB- cord-005453-4057qib7 8047 25 in in IN cord-005453-4057qib7 8047 26 1 1 CD cord-005453-4057qib7 8047 27 . . . cord-005453-4057qib7 8048 1 Twelve twelve CD cord-005453-4057qib7 8048 2 patients patient NNS cord-005453-4057qib7 8048 3 achieved achieve VBD cord-005453-4057qib7 8048 4 complete complete JJ cord-005453-4057qib7 8048 5 remission remission NN cord-005453-4057qib7 8048 6 ( ( -LRB- cord-005453-4057qib7 8048 7 CR CR NNP cord-005453-4057qib7 8048 8 ) ) -RRB- cord-005453-4057qib7 8048 9 and and CC cord-005453-4057qib7 8048 10 one one CD cord-005453-4057qib7 8048 11 was be VBD cord-005453-4057qib7 8048 12 refractory refractory JJ cord-005453-4057qib7 8048 13 ( ( -LRB- cord-005453-4057qib7 8048 14 1 1 CD cord-005453-4057qib7 8048 15 not not RB cord-005453-4057qib7 8048 16 evaluated evaluate VBN cord-005453-4057qib7 8048 17 ) ) -RRB- cord-005453-4057qib7 8048 18 . . . cord-005453-4057qib7 8049 1 In in IN cord-005453-4057qib7 8049 2 the the DT cord-005453-4057qib7 8049 3 R r NN cord-005453-4057qib7 8049 4 / / SYM cord-005453-4057qib7 8049 5 R r NN cord-005453-4057qib7 8049 6 setting setting NN cord-005453-4057qib7 8049 7 , , , cord-005453-4057qib7 8049 8 10 10 CD cord-005453-4057qib7 8049 9 patients patient NNS cord-005453-4057qib7 8049 10 diagnosed diagnose VBN cord-005453-4057qib7 8049 11 with with IN cord-005453-4057qib7 8049 12 AML AML NNP cord-005453-4057qib7 8049 13 ( ( -LRB- cord-005453-4057qib7 8049 14 n=8 n=8 NNP cord-005453-4057qib7 8049 15 ) ) -RRB- cord-005453-4057qib7 8049 16 , , , cord-005453-4057qib7 8049 17 biphenotypic biphenotypic JJ cord-005453-4057qib7 8049 18 acute acute JJ cord-005453-4057qib7 8049 19 leukemia leukemia NN cord-005453-4057qib7 8049 20 ( ( -LRB- cord-005453-4057qib7 8049 21 n=1 n=1 NN cord-005453-4057qib7 8049 22 ) ) -RRB- cord-005453-4057qib7 8049 23 and and CC cord-005453-4057qib7 8049 24 acute acute JJ cord-005453-4057qib7 8049 25 promyelocytic promyelocytic JJ cord-005453-4057qib7 8049 26 leukemia leukemia NN cord-005453-4057qib7 8049 27 ( ( -LRB- cord-005453-4057qib7 8049 28 n=1 n=1 NN cord-005453-4057qib7 8049 29 ) ) -RRB- cord-005453-4057qib7 8049 30 received receive VBD cord-005453-4057qib7 8049 31 GO GO NNP cord-005453-4057qib7 8049 32 as as IN cord-005453-4057qib7 8049 33 3rd 3rd JJ cord-005453-4057qib7 8049 34 or or CC cord-005453-4057qib7 8049 35 subsequent subsequent JJ cord-005453-4057qib7 8049 36 rescue rescue NN cord-005453-4057qib7 8049 37 therapy therapy NN cord-005453-4057qib7 8049 38 either either CC cord-005453-4057qib7 8049 39 as as IN cord-005453-4057qib7 8049 40 monotherapy monotherapy NN cord-005453-4057qib7 8049 41 ( ( -LRB- cord-005453-4057qib7 8049 42 n=4 n=4 NNP cord-005453-4057qib7 8049 43 ) ) -RRB- cord-005453-4057qib7 8049 44 or or CC cord-005453-4057qib7 8049 45 in in IN cord-005453-4057qib7 8049 46 combination combination NN cord-005453-4057qib7 8049 47 with with IN cord-005453-4057qib7 8049 48 cytotoxic cytotoxic JJ cord-005453-4057qib7 8049 49 chemotherapy chemotherapy NN cord-005453-4057qib7 8049 50 ( ( -LRB- cord-005453-4057qib7 8049 51 n=5 n=5 NNP cord-005453-4057qib7 8049 52 ) ) -RRB- cord-005453-4057qib7 8049 53 . . . cord-005453-4057qib7 8050 1 Prior Prior NNP cord-005453-4057qib7 8050 2 HSCT HSCT NNP cord-005453-4057qib7 8050 3 was be VBD cord-005453-4057qib7 8050 4 performed perform VBN cord-005453-4057qib7 8050 5 in in IN cord-005453-4057qib7 8050 6 5 5 CD cord-005453-4057qib7 8050 7 patients patient NNS cord-005453-4057qib7 8050 8 ( ( -LRB- cord-005453-4057qib7 8050 9 autologous autologous JJ cord-005453-4057qib7 8050 10 [ [ -LRB- cord-005453-4057qib7 8050 11 n=2 n=2 NNS cord-005453-4057qib7 8050 12 ] ] -RRB- cord-005453-4057qib7 8050 13 , , , cord-005453-4057qib7 8050 14 allogeneic allogeneic IN cord-005453-4057qib7 8050 15 [ [ -LRB- cord-005453-4057qib7 8050 16 n=3 n=3 NN cord-005453-4057qib7 8050 17 ] ] -RRB- cord-005453-4057qib7 8050 18 ) ) -RRB- cord-005453-4057qib7 8050 19 . . . cord-005453-4057qib7 8051 1 Rescue rescue NN cord-005453-4057qib7 8051 2 therapy therapy NN cord-005453-4057qib7 8051 3 was be VBD cord-005453-4057qib7 8051 4 indicated indicate VBN cord-005453-4057qib7 8051 5 for for IN cord-005453-4057qib7 8051 6 refractoriness refractoriness NNP cord-005453-4057qib7 8051 7 ( ( -LRB- cord-005453-4057qib7 8051 8 n=2 n=2 NNS cord-005453-4057qib7 8051 9 ) ) -RRB- cord-005453-4057qib7 8051 10 , , , cord-005453-4057qib7 8051 11 relapse relapse NN cord-005453-4057qib7 8051 12 ( ( -LRB- cord-005453-4057qib7 8051 13 n=5 n=5 NNP cord-005453-4057qib7 8051 14 ) ) -RRB- cord-005453-4057qib7 8051 15 , , , cord-005453-4057qib7 8051 16 partial partial JJ cord-005453-4057qib7 8051 17 response response NN cord-005453-4057qib7 8051 18 ( ( -LRB- cord-005453-4057qib7 8051 19 n=1 n=1 NN cord-005453-4057qib7 8051 20 ) ) -RRB- cord-005453-4057qib7 8051 21 or or CC cord-005453-4057qib7 8051 22 absence absence NN cord-005453-4057qib7 8051 23 of of IN cord-005453-4057qib7 8051 24 donor donor NN cord-005453-4057qib7 8051 25 ( ( -LRB- cord-005453-4057qib7 8051 26 n=2 n=2 NNS cord-005453-4057qib7 8051 27 ) ) -RRB- cord-005453-4057qib7 8051 28 . . . cord-005453-4057qib7 8052 1 Four four CD cord-005453-4057qib7 8052 2 patients patient NNS cord-005453-4057qib7 8052 3 received receive VBD cord-005453-4057qib7 8052 4 3 3 CD cord-005453-4057qib7 8052 5 doses dose NNS cord-005453-4057qib7 8052 6 of of IN cord-005453-4057qib7 8052 7 GO GO NNP cord-005453-4057qib7 8052 8 ( ( -LRB- cord-005453-4057qib7 8052 9 3 3 CD cord-005453-4057qib7 8052 10 mg mg NNP cord-005453-4057qib7 8052 11 / / SYM cord-005453-4057qib7 8052 12 m m NNP cord-005453-4057qib7 8052 13 2 2 CD cord-005453-4057qib7 8052 14 ) ) -RRB- cord-005453-4057qib7 8052 15 and and CC cord-005453-4057qib7 8052 16 3 3 CD cord-005453-4057qib7 8052 17 patients patient NNS cord-005453-4057qib7 8052 18 , , , cord-005453-4057qib7 8052 19 one one CD cord-005453-4057qib7 8052 20 dose dose NN cord-005453-4057qib7 8052 21 . . . cord-005453-4057qib7 8053 1 Hyperbilirubinemia Hyperbilirubinemia NNP cord-005453-4057qib7 8053 2 ( ( -LRB- cord-005453-4057qib7 8053 3 > > NFP cord-005453-4057qib7 8053 4 1.5 1.5 CD cord-005453-4057qib7 8053 5 UNL UNL NNP cord-005453-4057qib7 8053 6 ) ) -RRB- cord-005453-4057qib7 8053 7 was be VBD cord-005453-4057qib7 8053 8 observed observe VBN cord-005453-4057qib7 8053 9 in in IN cord-005453-4057qib7 8053 10 1 1 CD cord-005453-4057qib7 8053 11 patient patient NN cord-005453-4057qib7 8053 12 and and CC cord-005453-4057qib7 8053 13 increase increase NN cord-005453-4057qib7 8053 14 in in IN cord-005453-4057qib7 8053 15 AST ast NN cord-005453-4057qib7 8053 16 ( ( -LRB- cord-005453-4057qib7 8053 17 > > NFP cord-005453-4057qib7 8053 18 2.5 2.5 CD cord-005453-4057qib7 8053 19 UNL UNL NNP cord-005453-4057qib7 8053 20 ) ) -RRB- cord-005453-4057qib7 8053 21 in in IN cord-005453-4057qib7 8053 22 2 2 CD cord-005453-4057qib7 8053 23 patients patient NNS cord-005453-4057qib7 8053 24 . . . cord-005453-4057qib7 8054 1 Seven seven CD cord-005453-4057qib7 8054 2 patients patient NNS cord-005453-4057qib7 8054 3 achieved achieve VBD cord-005453-4057qib7 8054 4 CR CR NNP cord-005453-4057qib7 8054 5 , , , cord-005453-4057qib7 8054 6 1 1 CD cord-005453-4057qib7 8054 7 was be VBD cord-005453-4057qib7 8054 8 refractory refractory JJ cord-005453-4057qib7 8054 9 , , , cord-005453-4057qib7 8054 10 1 1 CD cord-005453-4057qib7 8054 11 obtained obtain VBD cord-005453-4057qib7 8054 12 partial partial JJ cord-005453-4057qib7 8054 13 response response NN cord-005453-4057qib7 8054 14 and and CC cord-005453-4057qib7 8054 15 1 1 CD cord-005453-4057qib7 8054 16 died die VBD cord-005453-4057qib7 8054 17 early early RB cord-005453-4057qib7 8054 18 during during IN cord-005453-4057qib7 8054 19 induction induction NN cord-005453-4057qib7 8054 20 ) ) -RRB- cord-005453-4057qib7 8054 21 . . . cord-005453-4057qib7 8055 1 Thirteen thirteen CD cord-005453-4057qib7 8055 2 patients patient NNS cord-005453-4057qib7 8055 3 received receive VBD cord-005453-4057qib7 8055 4 subsequent subsequent JJ cord-005453-4057qib7 8055 5 HSCT HSCT NNP cord-005453-4057qib7 8055 6 ( ( -LRB- cord-005453-4057qib7 8055 7 autologous autologous JJ cord-005453-4057qib7 8055 8 [ [ -LRB- cord-005453-4057qib7 8055 9 n=4 n=4 NNS cord-005453-4057qib7 8055 10 ] ] -RRB- cord-005453-4057qib7 8055 11 , , , cord-005453-4057qib7 8055 12 allogeneic allogeneic IN cord-005453-4057qib7 8055 13 [ [ -LRB- cord-005453-4057qib7 8055 14 n=9 n=9 NN cord-005453-4057qib7 8055 15 ] ] -RRB- cord-005453-4057qib7 8055 16 ) ) -RRB- cord-005453-4057qib7 8055 17 after after IN cord-005453-4057qib7 8055 18 GO GO NNP cord-005453-4057qib7 8055 19 therapy therapy NN cord-005453-4057qib7 8055 20 ( ( -LRB- cord-005453-4057qib7 8055 21 10 10 CD cord-005453-4057qib7 8055 22 in in IN cord-005453-4057qib7 8055 23 the the DT cord-005453-4057qib7 8055 24 de de FW cord-005453-4057qib7 8055 25 novo novo NNP cord-005453-4057qib7 8055 26 AML AML NNP cord-005453-4057qib7 8055 27 and and CC cord-005453-4057qib7 8055 28 3 3 CD cord-005453-4057qib7 8055 29 in in IN cord-005453-4057qib7 8055 30 the the DT cord-005453-4057qib7 8055 31 R r NN cord-005453-4057qib7 8055 32 / / SYM cord-005453-4057qib7 8055 33 R r NN cord-005453-4057qib7 8055 34 group group NN cord-005453-4057qib7 8055 35 ) ) -RRB- cord-005453-4057qib7 8055 36 . . . cord-005453-4057qib7 8056 1 The the DT cord-005453-4057qib7 8056 2 reasons reason NNS cord-005453-4057qib7 8056 3 for for IN cord-005453-4057qib7 8056 4 not not RB cord-005453-4057qib7 8056 5 performing perform VBG cord-005453-4057qib7 8056 6 HSCT HSCT NNP cord-005453-4057qib7 8056 7 in in IN cord-005453-4057qib7 8056 8 the the DT cord-005453-4057qib7 8056 9 remaining remain VBG cord-005453-4057qib7 8056 10 11 11 CD cord-005453-4057qib7 8056 11 patients patient NNS cord-005453-4057qib7 8056 12 were be VBD cord-005453-4057qib7 8056 13 : : : cord-005453-4057qib7 8056 14 low low JJ cord-005453-4057qib7 8056 15 cytogenetic cytogenetic JJ cord-005453-4057qib7 8056 16 risk risk NN cord-005453-4057qib7 8056 17 ( ( -LRB- cord-005453-4057qib7 8056 18 n=1 n=1 FW cord-005453-4057qib7 8056 19 ) ) -RRB- cord-005453-4057qib7 8056 20 , , , cord-005453-4057qib7 8056 21 active active JJ cord-005453-4057qib7 8056 22 chronic chronic JJ cord-005453-4057qib7 8056 23 graft graft NN cord-005453-4057qib7 8056 24 versus versus IN cord-005453-4057qib7 8056 25 host host NN cord-005453-4057qib7 8056 26 disease disease NN cord-005453-4057qib7 8056 27 ( ( -LRB- cord-005453-4057qib7 8056 28 GvHD GvHD NNP cord-005453-4057qib7 8056 29 ) ) -RRB- cord-005453-4057qib7 8056 30 in in IN cord-005453-4057qib7 8056 31 previous previous JJ cord-005453-4057qib7 8056 32 HSCT HSCT NNP cord-005453-4057qib7 8056 33 ( ( -LRB- cord-005453-4057qib7 8056 34 n=1 n=1 NNP cord-005453-4057qib7 8056 35 ) ) -RRB- cord-005453-4057qib7 8056 36 , , , cord-005453-4057qib7 8056 37 early early JJ cord-005453-4057qib7 8056 38 death death NN cord-005453-4057qib7 8056 39 during during IN cord-005453-4057qib7 8056 40 treatment treatment NN cord-005453-4057qib7 8056 41 ( ( -LRB- cord-005453-4057qib7 8056 42 n=3 n=3 NN cord-005453-4057qib7 8056 43 ) ) -RRB- cord-005453-4057qib7 8056 44 , , , cord-005453-4057qib7 8056 45 relapse relapse NN cord-005453-4057qib7 8056 46 ( ( -LRB- cord-005453-4057qib7 8056 47 n=1 n=1 CD cord-005453-4057qib7 8056 48 ) ) -RRB- cord-005453-4057qib7 8056 49 , , , cord-005453-4057qib7 8056 50 severe severe JJ cord-005453-4057qib7 8056 51 complications complication NNS cord-005453-4057qib7 8056 52 in in IN cord-005453-4057qib7 8056 53 rescue rescue NN cord-005453-4057qib7 8056 54 treatments treatment NNS cord-005453-4057qib7 8056 55 ( ( -LRB- cord-005453-4057qib7 8056 56 n=1 n=1 CD cord-005453-4057qib7 8056 57 ) ) -RRB- cord-005453-4057qib7 8056 58 , , , cord-005453-4057qib7 8056 59 and and CC cord-005453-4057qib7 8056 60 unknown unknown JJ cord-005453-4057qib7 8056 61 ( ( -LRB- cord-005453-4057qib7 8056 62 n=4 n=4 JJ cord-005453-4057qib7 8056 63 ) ) -RRB- cord-005453-4057qib7 8056 64 . . . cord-005453-4057qib7 8057 1 The the DT cord-005453-4057qib7 8057 2 conditioning conditioning NN cord-005453-4057qib7 8057 3 regimen regimen NN cord-005453-4057qib7 8057 4 was be VBD cord-005453-4057qib7 8057 5 myeloablative myeloablative NNP cord-005453-4057qib7 8057 6 ( ( -LRB- cord-005453-4057qib7 8057 7 n=8 n=8 NNP cord-005453-4057qib7 8057 8 ) ) -RRB- cord-005453-4057qib7 8057 9 , , , cord-005453-4057qib7 8057 10 non non JJ cord-005453-4057qib7 8057 11 - - JJ cord-005453-4057qib7 8057 12 myeloablative myeloablative JJ cord-005453-4057qib7 8057 13 ( ( -LRB- cord-005453-4057qib7 8057 14 n=4 n=4 JJ cord-005453-4057qib7 8057 15 ) ) -RRB- cord-005453-4057qib7 8057 16 and and CC cord-005453-4057qib7 8057 17 sequential sequential JJ cord-005453-4057qib7 8057 18 ( ( -LRB- cord-005453-4057qib7 8057 19 n=1 n=1 FW cord-005453-4057qib7 8057 20 ) ) -RRB- cord-005453-4057qib7 8057 21 , , , cord-005453-4057qib7 8057 22 and and CC cord-005453-4057qib7 8057 23 the the DT cord-005453-4057qib7 8057 24 donors donor NNS cord-005453-4057qib7 8057 25 were be VBD cord-005453-4057qib7 8057 26 matched match VBN cord-005453-4057qib7 8057 27 sibling sibling NN cord-005453-4057qib7 8057 28 ( ( -LRB- cord-005453-4057qib7 8057 29 n=6 n=6 NNP cord-005453-4057qib7 8057 30 ) ) -RRB- cord-005453-4057qib7 8057 31 or or CC cord-005453-4057qib7 8057 32 unrelated unrelated JJ cord-005453-4057qib7 8057 33 ( ( -LRB- cord-005453-4057qib7 8057 34 n=3 n=3 NN cord-005453-4057qib7 8057 35 ) ) -RRB- cord-005453-4057qib7 8057 36 . . . cord-005453-4057qib7 8058 1 Cyclosporine Cyclosporine NNP cord-005453-4057qib7 8058 2 , , , cord-005453-4057qib7 8058 3 methotrexate methotrexate NNP cord-005453-4057qib7 8058 4 and and CC cord-005453-4057qib7 8058 5 thymoglobulin thymoglobulin NNP cord-005453-4057qib7 8058 6 were be VBD cord-005453-4057qib7 8058 7 administered administer VBN cord-005453-4057qib7 8058 8 as as IN cord-005453-4057qib7 8058 9 GvHD GvHD NNP cord-005453-4057qib7 8058 10 prophylaxis prophylaxis NN cord-005453-4057qib7 8058 11 in in IN cord-005453-4057qib7 8058 12 7 7 CD cord-005453-4057qib7 8058 13 patients patient NNS cord-005453-4057qib7 8058 14 and and CC cord-005453-4057qib7 8058 15 cyclosporine cyclosporine NN cord-005453-4057qib7 8058 16 , , , cord-005453-4057qib7 8058 17 mycophenolate mycophenolate JJ cord-005453-4057qib7 8058 18 and and CC cord-005453-4057qib7 8058 19 thymoglobulin thymoglobulin NNP cord-005453-4057qib7 8058 20 in in IN cord-005453-4057qib7 8058 21 3 3 CD cord-005453-4057qib7 8058 22 . . . cord-005453-4057qib7 8059 1 Hyperbilirubinemia Hyperbilirubinemia NNP cord-005453-4057qib7 8059 2 was be VBD cord-005453-4057qib7 8059 3 observed observe VBN cord-005453-4057qib7 8059 4 in in IN cord-005453-4057qib7 8059 5 2 2 CD cord-005453-4057qib7 8059 6 patients patient NNS cord-005453-4057qib7 8059 7 belonging belong VBG cord-005453-4057qib7 8059 8 to to IN cord-005453-4057qib7 8059 9 the the DT cord-005453-4057qib7 8059 10 de de FW cord-005453-4057qib7 8059 11 novo novo NNP cord-005453-4057qib7 8059 12 AML AML NNP cord-005453-4057qib7 8059 13 group group NN cord-005453-4057qib7 8059 14 . . . cord-005453-4057qib7 8060 1 Death death NN cord-005453-4057qib7 8060 2 after after IN cord-005453-4057qib7 8060 3 HSCT HSCT NNP cord-005453-4057qib7 8060 4 occurred occur VBD cord-005453-4057qib7 8060 5 in in IN cord-005453-4057qib7 8060 6 10 10 CD cord-005453-4057qib7 8060 7 patients patient NNS cord-005453-4057qib7 8060 8 due due JJ cord-005453-4057qib7 8060 9 to to IN cord-005453-4057qib7 8060 10 infection infection NN cord-005453-4057qib7 8060 11 ( ( -LRB- cord-005453-4057qib7 8060 12 n=5 n=5 NNP cord-005453-4057qib7 8060 13 ) ) -RRB- cord-005453-4057qib7 8060 14 , , , cord-005453-4057qib7 8060 15 relapse relapse NN cord-005453-4057qib7 8060 16 ( ( -LRB- cord-005453-4057qib7 8060 17 n=3 n=3 NN cord-005453-4057qib7 8060 18 ) ) -RRB- cord-005453-4057qib7 8060 19 , , , cord-005453-4057qib7 8060 20 GvHD GvHD NNP cord-005453-4057qib7 8060 21 ( ( -LRB- cord-005453-4057qib7 8060 22 n=1 n=1 NNS cord-005453-4057qib7 8060 23 ) ) -RRB- cord-005453-4057qib7 8060 24 and and CC cord-005453-4057qib7 8060 25 traffic traffic NN cord-005453-4057qib7 8060 26 accident accident NN cord-005453-4057qib7 8060 27 ( ( -LRB- cord-005453-4057qib7 8060 28 n=1 n=1 FW cord-005453-4057qib7 8060 29 ) ) -RRB- cord-005453-4057qib7 8060 30 . . . cord-005453-4057qib7 8061 1 Three three CD cord-005453-4057qib7 8061 2 patients patient NNS cord-005453-4057qib7 8061 3 are be VBP cord-005453-4057qib7 8061 4 currently currently RB cord-005453-4057qib7 8061 5 alive alive JJ cord-005453-4057qib7 8061 6 in in IN cord-005453-4057qib7 8061 7 remission remission NN cord-005453-4057qib7 8061 8 . . . cord-005453-4057qib7 8062 1 No no DT cord-005453-4057qib7 8062 2 SOS SOS NNP cord-005453-4057qib7 8062 3 was be VBD cord-005453-4057qib7 8062 4 observed observe VBN cord-005453-4057qib7 8062 5 in in IN cord-005453-4057qib7 8062 6 any any DT cord-005453-4057qib7 8062 7 patient patient NN cord-005453-4057qib7 8062 8 . . . cord-005453-4057qib7 8063 1 Conclusions conclusion NNS cord-005453-4057qib7 8063 2 : : : cord-005453-4057qib7 8064 1 In in IN cord-005453-4057qib7 8064 2 both both DT cord-005453-4057qib7 8064 3 de de FW cord-005453-4057qib7 8064 4 novo novo NNP cord-005453-4057qib7 8064 5 and and CC cord-005453-4057qib7 8064 6 R R NNP cord-005453-4057qib7 8064 7 / / SYM cord-005453-4057qib7 8064 8 R R NNP cord-005453-4057qib7 8064 9 AML AML NNP cord-005453-4057qib7 8065 1 the the DT cord-005453-4057qib7 8065 2 administration administration NN cord-005453-4057qib7 8065 3 of of IN cord-005453-4057qib7 8065 4 low low JJ cord-005453-4057qib7 8065 5 dose dose NN cord-005453-4057qib7 8065 6 GO GO NNP cord-005453-4057qib7 8065 7 is be VBZ cord-005453-4057qib7 8065 8 feasible feasible JJ cord-005453-4057qib7 8065 9 and and CC cord-005453-4057qib7 8065 10 does do VBZ cord-005453-4057qib7 8065 11 not not RB cord-005453-4057qib7 8065 12 have have VB cord-005453-4057qib7 8065 13 impact impact NN cord-005453-4057qib7 8065 14 on on IN cord-005453-4057qib7 8065 15 subsequent subsequent JJ cord-005453-4057qib7 8065 16 HSCT HSCT NNP cord-005453-4057qib7 8065 17 outcome outcome NN cord-005453-4057qib7 8065 18 . . . cord-005453-4057qib7 8066 1 Although although IN cord-005453-4057qib7 8066 2 some some DT cord-005453-4057qib7 8066 3 degree degree NN cord-005453-4057qib7 8066 4 of of IN cord-005453-4057qib7 8066 5 hepatotoxicity hepatotoxicity NN cord-005453-4057qib7 8066 6 was be VBD cord-005453-4057qib7 8066 7 observed observe VBN cord-005453-4057qib7 8066 8 , , , cord-005453-4057qib7 8066 9 no no DT cord-005453-4057qib7 8066 10 cases case NNS cord-005453-4057qib7 8066 11 of of IN cord-005453-4057qib7 8066 12 SOS SOS NNP cord-005453-4057qib7 8066 13 were be VBD cord-005453-4057qib7 8066 14 observed observe VBN cord-005453-4057qib7 8066 15 , , , cord-005453-4057qib7 8066 16 either either CC cord-005453-4057qib7 8066 17 before before IN cord-005453-4057qib7 8066 18 or or CC cord-005453-4057qib7 8066 19 after after IN cord-005453-4057qib7 8066 20 HSCT HSCT NNP cord-005453-4057qib7 8066 21 . . . cord-005453-4057qib7 8067 1 Disclosure disclosure NN cord-005453-4057qib7 8067 2 : : : cord-005453-4057qib7 8067 3 Supported support VBN cord-005453-4057qib7 8067 4 by by IN cord-005453-4057qib7 8067 5 grants grant NNS cord-005453-4057qib7 8067 6 from from IN cord-005453-4057qib7 8067 7 : : : cord-005453-4057qib7 8067 8 Asociación Asociación NNP cord-005453-4057qib7 8067 9 Española Española NNP cord-005453-4057qib7 8067 10 Contra Contra NNP cord-005453-4057qib7 8067 11 el el NNP cord-005453-4057qib7 8067 12 Cáncer Cáncer NNP cord-005453-4057qib7 8067 13 , , , cord-005453-4057qib7 8067 14 AECC AECC NNP cord-005453-4057qib7 8067 15 ( ( -LRB- cord-005453-4057qib7 8067 16 GC16173697BIGA GC16173697BIGA NNP cord-005453-4057qib7 8067 17 ) ) -RRB- cord-005453-4057qib7 8067 18 , , , cord-005453-4057qib7 8067 19 Instituto Instituto NNP cord-005453-4057qib7 8067 20 Carlos Carlos NNP cord-005453-4057qib7 8067 21 III III NNP cord-005453-4057qib7 8067 22 ( ( -LRB- cord-005453-4057qib7 8067 23 PI14/01971 PI14/01971 NNP cord-005453-4057qib7 8067 24 FI FI NNP cord-005453-4057qib7 8067 25 ) ) -RRB- cord-005453-4057qib7 8067 26 , , , cord-005453-4057qib7 8067 27 2017-SGR288 2017-sgr288 CD cord-005453-4057qib7 8067 28 ( ( -LRB- cord-005453-4057qib7 8067 29 GRC GRC NNP cord-005453-4057qib7 8067 30 ) ) -RRB- cord-005453-4057qib7 8067 31 , , . cord-005453-4057qib7 8068 1 CERCA CERCA NNP cord-005453-4057qib7 8068 2 Program Program NNP cord-005453-4057qib7 8068 3 from from IN cord-005453-4057qib7 8068 4 Generalitat Generalitat NNP cord-005453-4057qib7 8068 5 de de NNP cord-005453-4057qib7 8068 6 Catalunya Catalunya NNP cord-005453-4057qib7 8068 7 , , , cord-005453-4057qib7 8068 8 and and CC cord-005453-4057qib7 8068 9 " " `` cord-005453-4057qib7 8068 10 La La NNP cord-005453-4057qib7 8068 11 Caixa Caixa NNP cord-005453-4057qib7 8068 12 " " '' cord-005453-4057qib7 8068 13 Foundation Foundation NNP cord-005453-4057qib7 8068 14 . . . cord-005453-4057qib7 8069 1 Outcome outcome NN cord-005453-4057qib7 8069 2 of of IN cord-005453-4057qib7 8069 3 allogeneic allogeneic JJ cord-005453-4057qib7 8069 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 8069 5 stem stem NN cord-005453-4057qib7 8069 6 cell cell NN cord-005453-4057qib7 8069 7 transplantation transplantation NN cord-005453-4057qib7 8069 8 in in IN cord-005453-4057qib7 8069 9 patients patient NNS cord-005453-4057qib7 8069 10 with with IN cord-005453-4057qib7 8069 11 benign benign JJ cord-005453-4057qib7 8069 12 hematological hematological JJ cord-005453-4057qib7 8069 13 disorders disorder NNS cord-005453-4057qib7 8069 14 Saqib Saqib NNP cord-005453-4057qib7 8069 15 Ansari Ansari NNP cord-005453-4057qib7 8069 16 1 1 CD cord-005453-4057qib7 8069 17 , , , cord-005453-4057qib7 8069 18 Tahir Tahir NNP cord-005453-4057qib7 8069 19 Shamsi Shamsi NNP cord-005453-4057qib7 8069 20 1 1 CD cord-005453-4057qib7 8069 21 , , , cord-005453-4057qib7 8069 22 Uzma Uzma NNP cord-005453-4057qib7 8069 23 Zaidi Zaidi NNP cord-005453-4057qib7 8069 24 1 1 CD cord-005453-4057qib7 8069 25 , , , cord-005453-4057qib7 8069 26 Saima Saima NNP cord-005453-4057qib7 8069 27 Siddiqui Siddiqui NNP cord-005453-4057qib7 8069 28 1 1 CD cord-005453-4057qib7 8069 29 , , , cord-005453-4057qib7 8069 30 Tasneem Tasneem NNP cord-005453-4057qib7 8069 31 Farzana Farzana NNP cord-005453-4057qib7 8069 32 1 1 CD cord-005453-4057qib7 8069 33 Background Background NNP cord-005453-4057qib7 8069 34 : : : cord-005453-4057qib7 8070 1 Allogeneic allogeneic IN cord-005453-4057qib7 8070 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 8070 3 stem stem NN cord-005453-4057qib7 8070 4 cell cell NN cord-005453-4057qib7 8070 5 transplantation transplantation NN cord-005453-4057qib7 8070 6 is be VBZ cord-005453-4057qib7 8070 7 a a DT cord-005453-4057qib7 8070 8 potentially potentially RB cord-005453-4057qib7 8070 9 curative curative JJ cord-005453-4057qib7 8070 10 treatment treatment NN cord-005453-4057qib7 8070 11 modality modality NN cord-005453-4057qib7 8070 12 for for IN cord-005453-4057qib7 8070 13 hematological hematological JJ cord-005453-4057qib7 8070 14 disorders disorder NNS cord-005453-4057qib7 8070 15 . . . cord-005453-4057qib7 8071 1 We -PRON- PRP cord-005453-4057qib7 8071 2 evaluated evaluate VBD cord-005453-4057qib7 8071 3 the the DT cord-005453-4057qib7 8071 4 outcome outcome NN cord-005453-4057qib7 8071 5 of of IN cord-005453-4057qib7 8071 6 patients patient NNS cord-005453-4057qib7 8071 7 suffering suffer VBG cord-005453-4057qib7 8071 8 from from IN cord-005453-4057qib7 8071 9 benign benign JJ cord-005453-4057qib7 8071 10 hematological hematological JJ cord-005453-4057qib7 8071 11 disorders disorder NNS cord-005453-4057qib7 8071 12 , , , cord-005453-4057qib7 8071 13 including include VBG cord-005453-4057qib7 8071 14 aplastic aplastic JJ cord-005453-4057qib7 8071 15 anemia anemia NN cord-005453-4057qib7 8071 16 , , , cord-005453-4057qib7 8071 17 fanconi fanconi NNP cord-005453-4057qib7 8071 18 's 's POS cord-005453-4057qib7 8071 19 anemia anemia NN cord-005453-4057qib7 8071 20 and and CC cord-005453-4057qib7 8071 21 thalassemia thalassemia NN cord-005453-4057qib7 8071 22 after after IN cord-005453-4057qib7 8071 23 matched match VBN cord-005453-4057qib7 8071 24 related related JJ cord-005453-4057qib7 8071 25 allogeneic allogeneic NN cord-005453-4057qib7 8071 26 transplantation transplantation NN cord-005453-4057qib7 8071 27 . . . cord-005453-4057qib7 8072 1 Methods method NNS cord-005453-4057qib7 8072 2 : : : cord-005453-4057qib7 8073 1 All all DT cord-005453-4057qib7 8073 2 patients patient NNS cord-005453-4057qib7 8073 3 having have VBG cord-005453-4057qib7 8073 4 hematological hematological JJ cord-005453-4057qib7 8073 5 disorders disorder NNS cord-005453-4057qib7 8073 6 including include VBG cord-005453-4057qib7 8073 7 aplastic aplastic JJ cord-005453-4057qib7 8073 8 anemia anemia NN cord-005453-4057qib7 8073 9 ( ( -LRB- cord-005453-4057qib7 8073 10 AA AA NNP cord-005453-4057qib7 8073 11 ) ) -RRB- cord-005453-4057qib7 8073 12 , , , cord-005453-4057qib7 8073 13 beta beta NN cord-005453-4057qib7 8073 14 thalassemia thalassemia NN cord-005453-4057qib7 8073 15 ( ( -LRB- cord-005453-4057qib7 8073 16 BTM BTM NNP cord-005453-4057qib7 8073 17 ) ) -RRB- cord-005453-4057qib7 8073 18 , , , cord-005453-4057qib7 8073 19 fanconi fanconi NNP cord-005453-4057qib7 8073 20 's 's POS cord-005453-4057qib7 8073 21 anemia anemia NN cord-005453-4057qib7 8073 22 ( ( -LRB- cord-005453-4057qib7 8073 23 FA FA NNP cord-005453-4057qib7 8073 24 ) ) -RRB- cord-005453-4057qib7 8073 25 and and CC cord-005453-4057qib7 8073 26 severe severe JJ cord-005453-4057qib7 8073 27 combined combine VBN cord-005453-4057qib7 8073 28 immune immune JJ cord-005453-4057qib7 8073 29 deficiency deficiency NN cord-005453-4057qib7 8073 30 disorder disorder NN cord-005453-4057qib7 8073 31 ( ( -LRB- cord-005453-4057qib7 8073 32 SCID SCID NNP cord-005453-4057qib7 8073 33 ) ) -RRB- cord-005453-4057qib7 8073 34 with with IN cord-005453-4057qib7 8073 35 HLA HLA NNP cord-005453-4057qib7 8073 36 identical identical JJ cord-005453-4057qib7 8073 37 related related JJ cord-005453-4057qib7 8073 38 donors donor NNS cord-005453-4057qib7 8073 39 who who WP cord-005453-4057qib7 8073 40 underwent undergo VBD cord-005453-4057qib7 8073 41 allogeneic allogeneic JJ cord-005453-4057qib7 8073 42 transplantation transplantation NN cord-005453-4057qib7 8073 43 were be VBD cord-005453-4057qib7 8073 44 included include VBN cord-005453-4057qib7 8073 45 . . . cord-005453-4057qib7 8074 1 Donors donor NNS cord-005453-4057qib7 8074 2 were be VBD cord-005453-4057qib7 8074 3 given give VBN cord-005453-4057qib7 8074 4 G G NNP cord-005453-4057qib7 8074 5 - - HYPH cord-005453-4057qib7 8074 6 CSF CSF NNP cord-005453-4057qib7 8074 7 at at IN cord-005453-4057qib7 8074 8 a a DT cord-005453-4057qib7 8074 9 dose dose NN cord-005453-4057qib7 8074 10 of of IN cord-005453-4057qib7 8074 11 10 10 CD cord-005453-4057qib7 8074 12 μg/ μg/ NNP cord-005453-4057qib7 8074 13 kg kg NNP cord-005453-4057qib7 8074 14 / / SYM cord-005453-4057qib7 8074 15 day day NN cord-005453-4057qib7 8074 16 daily daily RB cord-005453-4057qib7 8074 17 for for IN cord-005453-4057qib7 8074 18 four four CD cord-005453-4057qib7 8074 19 days day NNS cord-005453-4057qib7 8074 20 prior prior RB cord-005453-4057qib7 8074 21 to to IN cord-005453-4057qib7 8074 22 harvest harvest VB cord-005453-4057qib7 8074 23 . . . cord-005453-4057qib7 8075 1 The the DT cord-005453-4057qib7 8075 2 conditioning conditioning NN cord-005453-4057qib7 8075 3 regimens regimen NNS cord-005453-4057qib7 8075 4 for for IN cord-005453-4057qib7 8075 5 thalassemia thalassemia NN cord-005453-4057qib7 8075 6 included include VBN cord-005453-4057qib7 8075 7 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 8075 8 ( ( -LRB- cord-005453-4057qib7 8075 9 CY CY NNP cord-005453-4057qib7 8075 10 ) ) -RRB- cord-005453-4057qib7 8075 11 + + CC cord-005453-4057qib7 8075 12 busulfan busulfan NN cord-005453-4057qib7 8075 13 ( ( -LRB- cord-005453-4057qib7 8075 14 BU BU NNP cord-005453-4057qib7 8075 15 ) ) -RRB- cord-005453-4057qib7 8076 1 in in IN cord-005453-4057qib7 8076 2 21 21 CD cord-005453-4057qib7 8076 3 ( ( -LRB- cord-005453-4057qib7 8076 4 20 20 CD cord-005453-4057qib7 8076 5 % % NN cord-005453-4057qib7 8076 6 ) ) -RRB- cord-005453-4057qib7 8076 7 , , . cord-005453-4057qib7 8077 1 BU BU NNP cord-005453-4057qib7 8077 2 + + CC cord-005453-4057qib7 8077 3 CY CY NNP cord-005453-4057qib7 8077 4 + + CC cord-005453-4057qib7 8077 5 Thiotepa Thiotepa NNP cord-005453-4057qib7 8077 6 in in IN cord-005453-4057qib7 8077 7 4 4 CD cord-005453-4057qib7 8077 8 ( ( -LRB- cord-005453-4057qib7 8077 9 4 4 CD cord-005453-4057qib7 8077 10 % % NN cord-005453-4057qib7 8077 11 ) ) -RRB- cord-005453-4057qib7 8077 12 and and CC cord-005453-4057qib7 8077 13 BU BU NNP cord-005453-4057qib7 8077 14 + + SYM cord-005453-4057qib7 8077 15 CY CY NNP cord-005453-4057qib7 8077 16 + + CC cord-005453-4057qib7 8077 17 Antithymocyte Antithymocyte NNP cord-005453-4057qib7 8077 18 Globulin Globulin NNP cord-005453-4057qib7 8077 19 ( ( -LRB- cord-005453-4057qib7 8077 20 ATG ATG NNP cord-005453-4057qib7 8077 21 ) ) -RRB- cord-005453-4057qib7 8077 22 in in IN cord-005453-4057qib7 8077 23 81(76 81(76 CD cord-005453-4057qib7 8077 24 % % NN cord-005453-4057qib7 8077 25 ) ) -RRB- cord-005453-4057qib7 8077 26 . . . cord-005453-4057qib7 8078 1 Conditioning conditioning NN cord-005453-4057qib7 8078 2 regimens regimen NNS cord-005453-4057qib7 8078 3 for for IN cord-005453-4057qib7 8078 4 aplastic aplastic JJ cord-005453-4057qib7 8078 5 anemia anemia NN cord-005453-4057qib7 8078 6 included include VBN cord-005453-4057qib7 8078 7 , , , cord-005453-4057qib7 8078 8 Fludarabine Fludarabine NNP cord-005453-4057qib7 8078 9 ( ( -LRB- cord-005453-4057qib7 8078 10 FLU FLU NNP cord-005453-4057qib7 8078 11 ) ) -RRB- cord-005453-4057qib7 8078 12 + + SYM cord-005453-4057qib7 8078 13 CY CY NNP cord-005453-4057qib7 8078 14 in in IN cord-005453-4057qib7 8078 15 38 38 CD cord-005453-4057qib7 8078 16 ( ( -LRB- cord-005453-4057qib7 8078 17 33 33 CD cord-005453-4057qib7 8078 18 % % NN cord-005453-4057qib7 8078 19 ) ) -RRB- cord-005453-4057qib7 8078 20 , , , cord-005453-4057qib7 8078 21 FLU FLU NNP cord-005453-4057qib7 8078 22 + + SYM cord-005453-4057qib7 8078 23 ATG ATG NNP cord-005453-4057qib7 8078 24 in in IN cord-005453-4057qib7 8078 25 28 28 CD cord-005453-4057qib7 8078 26 ( ( -LRB- cord-005453-4057qib7 8078 27 25 25 CD cord-005453-4057qib7 8078 28 % % NN cord-005453-4057qib7 8078 29 ) ) -RRB- cord-005453-4057qib7 8078 30 and and CC cord-005453-4057qib7 8078 31 CY CY NNP cord-005453-4057qib7 8078 32 in in IN cord-005453-4057qib7 8078 33 38 38 CD cord-005453-4057qib7 8078 34 ( ( -LRB- cord-005453-4057qib7 8078 35 33 33 CD cord-005453-4057qib7 8078 36 % % NN cord-005453-4057qib7 8078 37 ) ) -RRB- cord-005453-4057qib7 8078 38 , , , cord-005453-4057qib7 8078 39 CY+ CY+ NNP cord-005453-4057qib7 8078 40 ATG ATG NNP cord-005453-4057qib7 8078 41 in in IN cord-005453-4057qib7 8078 42 9 9 CD cord-005453-4057qib7 8078 43 ( ( -LRB- cord-005453-4057qib7 8078 44 8 8 CD cord-005453-4057qib7 8078 45 % % NN cord-005453-4057qib7 8078 46 ) ) -RRB- cord-005453-4057qib7 8078 47 patients patient NNS cord-005453-4057qib7 8078 48 . . . cord-005453-4057qib7 8079 1 For for IN cord-005453-4057qib7 8079 2 Fanconi Fanconi NNP cord-005453-4057qib7 8079 3 's 's POS cord-005453-4057qib7 8079 4 Anemia Anemia NNP cord-005453-4057qib7 8079 5 FLU FLU NNP cord-005453-4057qib7 8079 6 + + CC cord-005453-4057qib7 8079 7 ATG ATG NNP cord-005453-4057qib7 8079 8 in in IN cord-005453-4057qib7 8079 9 12 12 CD cord-005453-4057qib7 8079 10 ( ( -LRB- cord-005453-4057qib7 8079 11 52 52 CD cord-005453-4057qib7 8079 12 % % NN cord-005453-4057qib7 8079 13 ) ) -RRB- cord-005453-4057qib7 8079 14 , , , cord-005453-4057qib7 8079 15 FLU flu NN cord-005453-4057qib7 8079 16 in in IN cord-005453-4057qib7 8079 17 2 2 CD cord-005453-4057qib7 8079 18 ( ( -LRB- cord-005453-4057qib7 8079 19 9 9 CD cord-005453-4057qib7 8079 20 % % NN cord-005453-4057qib7 8079 21 ) ) -RRB- cord-005453-4057qib7 8079 22 , , , cord-005453-4057qib7 8079 23 CY CY NNP cord-005453-4057qib7 8079 24 + + CC cord-005453-4057qib7 8079 25 ATG ATG NNP cord-005453-4057qib7 8079 26 in in IN cord-005453-4057qib7 8079 27 4 4 CD cord-005453-4057qib7 8079 28 ( ( -LRB- cord-005453-4057qib7 8079 29 17 17 CD cord-005453-4057qib7 8079 30 % % NN cord-005453-4057qib7 8079 31 ) ) -RRB- cord-005453-4057qib7 8079 32 and and CC cord-005453-4057qib7 8079 33 FLU+ FLU+ NNP cord-005453-4057qib7 8079 34 CY CY NNP cord-005453-4057qib7 8079 35 + + CC cord-005453-4057qib7 8079 36 ATG ATG NNP cord-005453-4057qib7 8079 37 in in IN cord-005453-4057qib7 8079 38 5 5 CD cord-005453-4057qib7 8079 39 ( ( -LRB- cord-005453-4057qib7 8079 40 22 22 CD cord-005453-4057qib7 8079 41 % % NN cord-005453-4057qib7 8079 42 ) ) -RRB- cord-005453-4057qib7 8079 43 . . . cord-005453-4057qib7 8080 1 FLU FLU NNP cord-005453-4057qib7 8080 2 + + SYM cord-005453-4057qib7 8080 3 ATG ATG NNP cord-005453-4057qib7 8080 4 in in IN cord-005453-4057qib7 8080 5 2(25 2(25 CD cord-005453-4057qib7 8080 6 % % NN cord-005453-4057qib7 8080 7 ) ) -RRB- cord-005453-4057qib7 8080 8 and and CC cord-005453-4057qib7 8080 9 Cy Cy NNP cord-005453-4057qib7 8080 10 given give VBN cord-005453-4057qib7 8080 11 in in IN cord-005453-4057qib7 8080 12 4 4 CD cord-005453-4057qib7 8080 13 ( ( -LRB- cord-005453-4057qib7 8080 14 50 50 CD cord-005453-4057qib7 8080 15 % % NN cord-005453-4057qib7 8080 16 ) ) -RRB- cord-005453-4057qib7 8080 17 and and CC cord-005453-4057qib7 8080 18 no no DT cord-005453-4057qib7 8080 19 conditioning conditioning NN cord-005453-4057qib7 8080 20 regimen regimen NN cord-005453-4057qib7 8080 21 was be VBD cord-005453-4057qib7 8080 22 offered offer VBN cord-005453-4057qib7 8080 23 to to IN cord-005453-4057qib7 8080 24 2 2 CD cord-005453-4057qib7 8080 25 ( ( -LRB- cord-005453-4057qib7 8080 26 25 25 CD cord-005453-4057qib7 8080 27 % % NN cord-005453-4057qib7 8080 28 ) ) -RRB- cord-005453-4057qib7 8080 29 patients patient NNS cord-005453-4057qib7 8080 30 with with IN cord-005453-4057qib7 8080 31 SCID SCID NNP cord-005453-4057qib7 8080 32 . . . cord-005453-4057qib7 8081 1 Results result NNS cord-005453-4057qib7 8081 2 : : : cord-005453-4057qib7 8082 1 A a DT cord-005453-4057qib7 8082 2 total total NN cord-005453-4057qib7 8082 3 of of IN cord-005453-4057qib7 8082 4 250 250 CD cord-005453-4057qib7 8082 5 allogeneic allogeneic NN cord-005453-4057qib7 8082 6 transplants transplant NNS cord-005453-4057qib7 8082 7 were be VBD cord-005453-4057qib7 8082 8 performed perform VBN cord-005453-4057qib7 8082 9 for for IN cord-005453-4057qib7 8082 10 benign benign JJ cord-005453-4057qib7 8082 11 hematological hematological JJ cord-005453-4057qib7 8082 12 disorders disorder NNS cord-005453-4057qib7 8082 13 including include VBG cord-005453-4057qib7 8082 14 AA AA NNP cord-005453-4057qib7 8082 15 ( ( -LRB- cord-005453-4057qib7 8082 16 n=113 n=113 NNP cord-005453-4057qib7 8082 17 ) ) -RRB- cord-005453-4057qib7 8082 18 , , , cord-005453-4057qib7 8082 19 BTM BTM NNP cord-005453-4057qib7 8082 20 ( ( -LRB- cord-005453-4057qib7 8082 21 n=106 n=106 NNP cord-005453-4057qib7 8082 22 ) ) -RRB- cord-005453-4057qib7 8082 23 , , , cord-005453-4057qib7 8082 24 FA FA NNP cord-005453-4057qib7 8082 25 ( ( -LRB- cord-005453-4057qib7 8082 26 n=23 n=23 NNP cord-005453-4057qib7 8082 27 ) ) -RRB- cord-005453-4057qib7 8082 28 and and CC cord-005453-4057qib7 8082 29 SCID SCID NNP cord-005453-4057qib7 8082 30 ( ( -LRB- cord-005453-4057qib7 8082 31 n=8 n=8 NN cord-005453-4057qib7 8082 32 ) ) -RRB- cord-005453-4057qib7 8082 33 from from IN cord-005453-4057qib7 8082 34 2011 2011 CD cord-005453-4057qib7 8082 35 to to IN cord-005453-4057qib7 8082 36 July July NNP cord-005453-4057qib7 8082 37 2018 2018 CD cord-005453-4057qib7 8082 38 . . . cord-005453-4057qib7 8083 1 Median median JJ cord-005453-4057qib7 8083 2 age age NN cord-005453-4057qib7 8083 3 was be VBD cord-005453-4057qib7 8083 4 7.5 7.5 CD cord-005453-4057qib7 8083 5 years year NNS cord-005453-4057qib7 8083 6 ( ( -LRB- cord-005453-4057qib7 8083 7 range range VBP cord-005453-4057qib7 8083 8 0.5 0.5 CD cord-005453-4057qib7 8083 9 -48 -48 CD cord-005453-4057qib7 8083 10 ) ) -RRB- cord-005453-4057qib7 8083 11 . . . cord-005453-4057qib7 8084 1 Across across IN cord-005453-4057qib7 8084 2 the the DT cord-005453-4057qib7 8084 3 gender gender NN cord-005453-4057qib7 8084 4 and and CC cord-005453-4057qib7 8084 5 ABO ABO NNP cord-005453-4057qib7 8084 6 blood blood NN cord-005453-4057qib7 8084 7 group group NN cord-005453-4057qib7 8084 8 transplants transplant NNS cord-005453-4057qib7 8084 9 were be VBD cord-005453-4057qib7 8084 10 109 109 CD cord-005453-4057qib7 8084 11 ( ( -LRB- cord-005453-4057qib7 8084 12 43.6 43.6 CD cord-005453-4057qib7 8084 13 % % NN cord-005453-4057qib7 8084 14 ) ) -RRB- cord-005453-4057qib7 8084 15 and and CC cord-005453-4057qib7 8084 16 80 80 CD cord-005453-4057qib7 8084 17 ( ( -LRB- cord-005453-4057qib7 8084 18 32 32 CD cord-005453-4057qib7 8084 19 % % NN cord-005453-4057qib7 8084 20 ) ) -RRB- cord-005453-4057qib7 8084 21 . . . cord-005453-4057qib7 8085 1 The the DT cord-005453-4057qib7 8085 2 median median JJ cord-005453-4057qib7 8085 3 time time NN cord-005453-4057qib7 8085 4 to to IN cord-005453-4057qib7 8085 5 neutrophil neutrophil NN cord-005453-4057qib7 8085 6 and and CC cord-005453-4057qib7 8085 7 platelet platelet NN cord-005453-4057qib7 8085 8 recovery recovery NN cord-005453-4057qib7 8085 9 was be VBD cord-005453-4057qib7 8085 10 13 13 CD cord-005453-4057qib7 8085 11 days day NNS cord-005453-4057qib7 8086 1 ( ( -LRB- cord-005453-4057qib7 8086 2 range range NN cord-005453-4057qib7 8086 3 : : : cord-005453-4057qib7 8086 4 9 9 CD cord-005453-4057qib7 8086 5 - - SYM cord-005453-4057qib7 8086 6 46 46 CD cord-005453-4057qib7 8086 7 ) ) -RRB- cord-005453-4057qib7 8086 8 and and CC cord-005453-4057qib7 8086 9 18 18 CD cord-005453-4057qib7 8086 10 ( ( -LRB- cord-005453-4057qib7 8086 11 range range NN cord-005453-4057qib7 8086 12 : : : cord-005453-4057qib7 8086 13 10 10 CD cord-005453-4057qib7 8086 14 - - SYM cord-005453-4057qib7 8086 15 35 35 CD cord-005453-4057qib7 8086 16 ) ) -RRB- cord-005453-4057qib7 8086 17 . . . cord-005453-4057qib7 8087 1 Primary primary JJ cord-005453-4057qib7 8087 2 and and CC cord-005453-4057qib7 8087 3 secondary secondary JJ cord-005453-4057qib7 8087 4 graft graft NN cord-005453-4057qib7 8087 5 failure failure NN cord-005453-4057qib7 8087 6 was be VBD cord-005453-4057qib7 8087 7 observed observe VBN cord-005453-4057qib7 8087 8 in in IN cord-005453-4057qib7 8087 9 34 34 CD cord-005453-4057qib7 8087 10 ( ( -LRB- cord-005453-4057qib7 8087 11 13.6 13.6 CD cord-005453-4057qib7 8087 12 % % NN cord-005453-4057qib7 8087 13 ) ) -RRB- cord-005453-4057qib7 8087 14 and and CC cord-005453-4057qib7 8087 15 29 29 CD cord-005453-4057qib7 8087 16 ( ( -LRB- cord-005453-4057qib7 8087 17 11.6 11.6 CD cord-005453-4057qib7 8087 18 % % NN cord-005453-4057qib7 8087 19 ) ) -RRB- cord-005453-4057qib7 8087 20 . . . cord-005453-4057qib7 8088 1 Overall overall JJ cord-005453-4057qib7 8088 2 survival survival NN cord-005453-4057qib7 8088 3 in in IN cord-005453-4057qib7 8088 4 aplastic aplastic JJ cord-005453-4057qib7 8088 5 anemia anemia NN cord-005453-4057qib7 8088 6 ( ( -LRB- cord-005453-4057qib7 8088 7 63/113 63/113 CD cord-005453-4057qib7 8088 8 , , , cord-005453-4057qib7 8088 9 56 56 CD cord-005453-4057qib7 8088 10 % % NN cord-005453-4057qib7 8088 11 ) ) -RRB- cord-005453-4057qib7 8088 12 , , , cord-005453-4057qib7 8088 13 beta beta NN cord-005453-4057qib7 8088 14 thalassemia thalassemia NN cord-005453-4057qib7 8088 15 ( ( -LRB- cord-005453-4057qib7 8088 16 82/106 82/106 CD cord-005453-4057qib7 8088 17 , , , cord-005453-4057qib7 8088 18 77%),fanconi 77%),fanconi CD cord-005453-4057qib7 8088 19 's 's POS cord-005453-4057qib7 8088 20 anemia anemia NN cord-005453-4057qib7 8088 21 ( ( -LRB- cord-005453-4057qib7 8088 22 15/23 15/23 CD cord-005453-4057qib7 8088 23 , , , cord-005453-4057qib7 8088 24 65 65 CD cord-005453-4057qib7 8088 25 % % NN cord-005453-4057qib7 8088 26 ) ) -RRB- cord-005453-4057qib7 8088 27 and and CC cord-005453-4057qib7 8088 28 severe severe JJ cord-005453-4057qib7 8088 29 combined combine VBN cord-005453-4057qib7 8088 30 immune immune JJ cord-005453-4057qib7 8088 31 deficiency deficiency NN cord-005453-4057qib7 8088 32 disorder disorder NN cord-005453-4057qib7 8088 33 ( ( -LRB- cord-005453-4057qib7 8088 34 6/8 6/8 CD cord-005453-4057qib7 8088 35 , , , cord-005453-4057qib7 8088 36 75 75 CD cord-005453-4057qib7 8088 37 % % NN cord-005453-4057qib7 8088 38 ) ) -RRB- cord-005453-4057qib7 8088 39 . . . cord-005453-4057qib7 8089 1 Eighty eighty CD cord-005453-4057qib7 8089 2 four four CD cord-005453-4057qib7 8089 3 patients patient NNS cord-005453-4057qib7 8089 4 expired expire VBD cord-005453-4057qib7 8089 5 ( ( -LRB- cord-005453-4057qib7 8089 6 33.6 33.6 CD cord-005453-4057qib7 8089 7 % % NN cord-005453-4057qib7 8089 8 ) ) -RRB- cord-005453-4057qib7 8089 9 among among IN cord-005453-4057qib7 8089 10 them -PRON- PRP cord-005453-4057qib7 8089 11 41 41 CD cord-005453-4057qib7 8089 12 patients patient NNS cord-005453-4057qib7 8089 13 expired expire VBD cord-005453-4057qib7 8089 14 within within IN cord-005453-4057qib7 8089 15 100 100 CD cord-005453-4057qib7 8089 16 days day NNS cord-005453-4057qib7 8089 17 post post NN cord-005453-4057qib7 8089 18 transplant transplant NN cord-005453-4057qib7 8089 19 Main main JJ cord-005453-4057qib7 8089 20 cause cause NN cord-005453-4057qib7 8089 21 of of IN cord-005453-4057qib7 8089 22 deaths death NNS cord-005453-4057qib7 8089 23 included include VBD cord-005453-4057qib7 8089 24 sepsis sepsis NN cord-005453-4057qib7 8089 25 ( ( -LRB- cord-005453-4057qib7 8089 26 31 31 CD cord-005453-4057qib7 8089 27 % % NN cord-005453-4057qib7 8089 28 ) ) -RRB- cord-005453-4057qib7 8089 29 , , , cord-005453-4057qib7 8089 30 multi multi JJ cord-005453-4057qib7 8089 31 organ organ NN cord-005453-4057qib7 8089 32 failure failure NN cord-005453-4057qib7 8089 33 ( ( -LRB- cord-005453-4057qib7 8089 34 6 6 CD cord-005453-4057qib7 8089 35 % % NN cord-005453-4057qib7 8089 36 ) ) -RRB- cord-005453-4057qib7 8089 37 and and CC cord-005453-4057qib7 8089 38 Gut Gut NNP cord-005453-4057qib7 8089 39 GvHD GvHD NNP cord-005453-4057qib7 8089 40 ( ( -LRB- cord-005453-4057qib7 8089 41 5 5 CD cord-005453-4057qib7 8089 42 % % NN cord-005453-4057qib7 8089 43 ) ) -RRB- cord-005453-4057qib7 8090 1 Conclusions conclusion NNS cord-005453-4057qib7 8090 2 : : : cord-005453-4057qib7 8091 1 In in IN cord-005453-4057qib7 8091 2 developing develop VBG cord-005453-4057qib7 8091 3 world world NN cord-005453-4057qib7 8091 4 scenario scenario NN cord-005453-4057qib7 8091 5 where where WRB cord-005453-4057qib7 8091 6 non non JJ cord-005453-4057qib7 8091 7 malignant malignant JJ cord-005453-4057qib7 8091 8 disorders disorder NNS cord-005453-4057qib7 8091 9 are be VBP cord-005453-4057qib7 8091 10 leading lead VBG cord-005453-4057qib7 8091 11 cause cause NN cord-005453-4057qib7 8091 12 of of IN cord-005453-4057qib7 8091 13 morbidity morbidity NN cord-005453-4057qib7 8091 14 and and CC cord-005453-4057qib7 8091 15 mortality mortality NN cord-005453-4057qib7 8091 16 . . . cord-005453-4057qib7 8092 1 Bone Bone NNP cord-005453-4057qib7 8092 2 Marrow Marrow NNP cord-005453-4057qib7 8092 3 Transplantation transplantation NN cord-005453-4057qib7 8092 4 has have VBZ cord-005453-4057qib7 8092 5 been be VBN cord-005453-4057qib7 8092 6 successfully successfully RB cord-005453-4057qib7 8092 7 implemented implement VBN cord-005453-4057qib7 8092 8 with with IN cord-005453-4057qib7 8092 9 better well JJR cord-005453-4057qib7 8092 10 long long JJ cord-005453-4057qib7 8092 11 term term NN cord-005453-4057qib7 8092 12 diseases disease NNS cord-005453-4057qib7 8092 13 free free JJ cord-005453-4057qib7 8092 14 survival survival NN cord-005453-4057qib7 8092 15 and and CC cord-005453-4057qib7 8092 16 quality quality NN cord-005453-4057qib7 8092 17 of of IN cord-005453-4057qib7 8092 18 life life NN cord-005453-4057qib7 8092 19 . . . cord-005453-4057qib7 8093 1 Clinical clinical JJ cord-005453-4057qib7 8093 2 Background background NN cord-005453-4057qib7 8093 3 : : : cord-005453-4057qib7 8093 4 Hematopoietic hematopoietic JJ cord-005453-4057qib7 8093 5 cell cell NN cord-005453-4057qib7 8093 6 transplantation transplantation NN cord-005453-4057qib7 8093 7 ( ( -LRB- cord-005453-4057qib7 8093 8 HCT HCT NNP cord-005453-4057qib7 8093 9 ) ) -RRB- cord-005453-4057qib7 8093 10 remains remain VBZ cord-005453-4057qib7 8093 11 the the DT cord-005453-4057qib7 8093 12 only only JJ cord-005453-4057qib7 8093 13 curative curative JJ cord-005453-4057qib7 8093 14 therapy therapy NN cord-005453-4057qib7 8093 15 for for IN cord-005453-4057qib7 8093 16 many many JJ cord-005453-4057qib7 8093 17 diseases disease NNS cord-005453-4057qib7 8093 18 , , , cord-005453-4057qib7 8093 19 yet yet CC cord-005453-4057qib7 8093 20 transplant transplant NN cord-005453-4057qib7 8093 21 survivors survivor NNS cord-005453-4057qib7 8093 22 carry carry VBP cord-005453-4057qib7 8093 23 an an DT cord-005453-4057qib7 8093 24 unusually unusually RB cord-005453-4057qib7 8093 25 high high JJ cord-005453-4057qib7 8093 26 burden burden NN cord-005453-4057qib7 8093 27 of of IN cord-005453-4057qib7 8093 28 morbidities morbidity NNS cord-005453-4057qib7 8093 29 , , , cord-005453-4057qib7 8093 30 primarily primarily RB cord-005453-4057qib7 8093 31 because because IN cord-005453-4057qib7 8093 32 of of IN cord-005453-4057qib7 8093 33 exposure exposure NN cord-005453-4057qib7 8093 34 to to IN cord-005453-4057qib7 8093 35 intense intense JJ cord-005453-4057qib7 8093 36 chemotherapy chemotherapy NN cord-005453-4057qib7 8093 37 , , , cord-005453-4057qib7 8093 38 radiation radiation NN cord-005453-4057qib7 8093 39 and and CC cord-005453-4057qib7 8093 40 /or /or . cord-005453-4057qib7 8093 41 GVHD GVHD NNP cord-005453-4057qib7 8093 42 . . . cord-005453-4057qib7 8094 1 This this DT cord-005453-4057qib7 8094 2 study study NN cord-005453-4057qib7 8094 3 aimed aim VBD cord-005453-4057qib7 8094 4 to to TO cord-005453-4057qib7 8094 5 evaluate evaluate VB cord-005453-4057qib7 8094 6 the the DT cord-005453-4057qib7 8094 7 burden burden NN cord-005453-4057qib7 8094 8 of of IN cord-005453-4057qib7 8094 9 chronic chronic JJ cord-005453-4057qib7 8094 10 diseases disease NNS cord-005453-4057qib7 8094 11 at at IN cord-005453-4057qib7 8094 12 the the DT cord-005453-4057qib7 8094 13 end end NN cord-005453-4057qib7 8094 14 of of IN cord-005453-4057qib7 8094 15 life life NN cord-005453-4057qib7 8094 16 after after IN cord-005453-4057qib7 8094 17 allogeneic allogeneic NN cord-005453-4057qib7 8094 18 - - HYPH cord-005453-4057qib7 8094 19 HCT hct NN cord-005453-4057qib7 8094 20 and and CC cord-005453-4057qib7 8094 21 to to TO cord-005453-4057qib7 8094 22 identify identify VB cord-005453-4057qib7 8094 23 the the DT cord-005453-4057qib7 8094 24 disability disability NN cord-005453-4057qib7 8094 25 - - HYPH cord-005453-4057qib7 8094 26 adjusted adjust VBN cord-005453-4057qib7 8094 27 life life NN cord-005453-4057qib7 8094 28 years year NNS cord-005453-4057qib7 8094 29 ( ( -LRB- cord-005453-4057qib7 8094 30 DALY DALY NNP cord-005453-4057qib7 8094 31 ) ) -RRB- cord-005453-4057qib7 8094 32 . . . cord-005453-4057qib7 8095 1 Methods method NNS cord-005453-4057qib7 8095 2 : : : cord-005453-4057qib7 8095 3 The the DT cord-005453-4057qib7 8095 4 PubMed PubMed NNP cord-005453-4057qib7 8095 5 , , , cord-005453-4057qib7 8095 6 MEDLINE MEDLINE NNP cord-005453-4057qib7 8095 7 , , , cord-005453-4057qib7 8095 8 and and CC cord-005453-4057qib7 8095 9 OVID OVID NNP cord-005453-4057qib7 8095 10 databases database NNS cord-005453-4057qib7 8095 11 were be VBD cord-005453-4057qib7 8095 12 queried query VBN cord-005453-4057qib7 8095 13 utilizing utilize VBG cord-005453-4057qib7 8095 14 specific specific JJ cord-005453-4057qib7 8095 15 MeSH mesh JJ cord-005453-4057qib7 8095 16 terminology terminology NN cord-005453-4057qib7 8095 17 ( ( -LRB- cord-005453-4057qib7 8095 18 post post AFX cord-005453-4057qib7 8095 19 , , , cord-005453-4057qib7 8095 20 allo allo VB cord-005453-4057qib7 8095 21 stem stem NN cord-005453-4057qib7 8095 22 cell cell NN cord-005453-4057qib7 8095 23 , , , cord-005453-4057qib7 8095 24 hematopoietic hematopoietic JJ cord-005453-4057qib7 8095 25 , , , cord-005453-4057qib7 8095 26 bone bone NN cord-005453-4057qib7 8095 27 marrow marrow NN cord-005453-4057qib7 8095 28 , , , cord-005453-4057qib7 8095 29 transplantation).We transplantation).We NNP cord-005453-4057qib7 8095 30 collected collect VBD cord-005453-4057qib7 8095 31 data datum NNS cord-005453-4057qib7 8095 32 on on IN cord-005453-4057qib7 8095 33 the the DT cord-005453-4057qib7 8095 34 impact impact NN cord-005453-4057qib7 8095 35 of of IN cord-005453-4057qib7 8095 36 the the DT cord-005453-4057qib7 8095 37 HCT hct NN cord-005453-4057qib7 8095 38 on on IN cord-005453-4057qib7 8095 39 the the DT cord-005453-4057qib7 8095 40 variables variable NNS cord-005453-4057qib7 8095 41 affecting affect VBG cord-005453-4057qib7 8095 42 survivor survivor NN cord-005453-4057qib7 8095 43 's 's POS cord-005453-4057qib7 8095 44 health health NN cord-005453-4057qib7 8095 45 in in IN cord-005453-4057qib7 8095 46 all all DT cord-005453-4057qib7 8095 47 aspects aspect NNS cord-005453-4057qib7 8095 48 .The .The . cord-005453-4057qib7 8096 1 rates rate NNS cord-005453-4057qib7 8096 2 of of IN cord-005453-4057qib7 8096 3 late late JJ cord-005453-4057qib7 8096 4 complications complication NNS cord-005453-4057qib7 8096 5 were be VBD cord-005453-4057qib7 8096 6 compared compare VBN cord-005453-4057qib7 8096 7 to to IN cord-005453-4057qib7 8096 8 the the DT cord-005453-4057qib7 8096 9 risks risk NNS cord-005453-4057qib7 8096 10 in in IN cord-005453-4057qib7 8096 11 the the DT cord-005453-4057qib7 8096 12 general general JJ cord-005453-4057qib7 8096 13 population population NN cord-005453-4057qib7 8096 14 ( ( -LRB- cord-005453-4057qib7 8096 15 United United NNP cord-005453-4057qib7 8096 16 States States NNP cord-005453-4057qib7 8096 17 ) ) -RRB- cord-005453-4057qib7 8096 18 . . . cord-005453-4057qib7 8097 1 Results result NNS cord-005453-4057qib7 8097 2 : : : cord-005453-4057qib7 8098 1 A a DT cord-005453-4057qib7 8098 2 total total NN cord-005453-4057qib7 8098 3 of of IN cord-005453-4057qib7 8098 4 7 7 CD cord-005453-4057qib7 8098 5 studies study NNS cord-005453-4057qib7 8098 6 fulfilled fulfil VBD cord-005453-4057qib7 8098 7 the the DT cord-005453-4057qib7 8098 8 selection selection NN cord-005453-4057qib7 8098 9 criteria criterion NNS cord-005453-4057qib7 8098 10 totaling total VBG cord-005453-4057qib7 8098 11 to to IN cord-005453-4057qib7 8098 12 6619 6619 CD cord-005453-4057qib7 8098 13 patients patient NNS cord-005453-4057qib7 8098 14 ( ( -LRB- cord-005453-4057qib7 8098 15 Table table NN cord-005453-4057qib7 8098 16 1 1 CD cord-005453-4057qib7 8098 17 ) ) -RRB- cord-005453-4057qib7 8098 18 . . . cord-005453-4057qib7 8099 1 Median median JJ cord-005453-4057qib7 8099 2 OS OS NNP cord-005453-4057qib7 8099 3 at at IN cord-005453-4057qib7 8099 4 5-year 5-year CD cord-005453-4057qib7 8099 5 mark mark NN cord-005453-4057qib7 8099 6 varied vary VBN cord-005453-4057qib7 8099 7 widely widely RB cord-005453-4057qib7 8099 8 between between IN cord-005453-4057qib7 8099 9 studies study NNS cord-005453-4057qib7 8099 10 from from IN cord-005453-4057qib7 8099 11 19 19 CD cord-005453-4057qib7 8099 12 % % NN cord-005453-4057qib7 8099 13 to to IN cord-005453-4057qib7 8099 14 92 92 CD cord-005453-4057qib7 8099 15 % % NN cord-005453-4057qib7 8099 16 . . . cord-005453-4057qib7 8100 1 Majority majority NN cord-005453-4057qib7 8100 2 of of IN cord-005453-4057qib7 8100 3 the the DT cord-005453-4057qib7 8100 4 patients patient NNS cord-005453-4057qib7 8100 5 at at IN cord-005453-4057qib7 8100 6 10-year 10-year CD cord-005453-4057qib7 8100 7 mark mark NN cord-005453-4057qib7 8100 8 were be VBD cord-005453-4057qib7 8100 9 found find VBN cord-005453-4057qib7 8100 10 to to TO cord-005453-4057qib7 8100 11 have have VB cord-005453-4057qib7 8100 12 new new JJ cord-005453-4057qib7 8100 13 comorbidities comorbiditie NNS cord-005453-4057qib7 8100 14 thereby thereby RB cord-005453-4057qib7 8100 15 indicating indicate VBG cord-005453-4057qib7 8100 16 a a DT cord-005453-4057qib7 8100 17 huge huge JJ cord-005453-4057qib7 8100 18 burden burden NN cord-005453-4057qib7 8100 19 of of IN cord-005453-4057qib7 8100 20 late late JJ cord-005453-4057qib7 8100 21 effects effect NNS cord-005453-4057qib7 8100 22 at at IN cord-005453-4057qib7 8100 23 the the DT cord-005453-4057qib7 8100 24 end end NN cord-005453-4057qib7 8100 25 of of IN cord-005453-4057qib7 8100 26 life life NN cord-005453-4057qib7 8100 27 , , , cord-005453-4057qib7 8100 28 though though IN cord-005453-4057qib7 8100 29 exact exact JJ cord-005453-4057qib7 8100 30 DALYs daly NNS cord-005453-4057qib7 8100 31 could could MD cord-005453-4057qib7 8100 32 not not RB cord-005453-4057qib7 8100 33 be be VB cord-005453-4057qib7 8100 34 calculated calculate VBN cord-005453-4057qib7 8100 35 due due IN cord-005453-4057qib7 8100 36 to to IN cord-005453-4057qib7 8100 37 incomplete incomplete JJ cord-005453-4057qib7 8100 38 data datum NNS cord-005453-4057qib7 8100 39 . . . cord-005453-4057qib7 8101 1 HCT HCT NNP cord-005453-4057qib7 8101 2 survivors survivor NNS cord-005453-4057qib7 8101 3 were be VBD cord-005453-4057qib7 8101 4 found find VBN cord-005453-4057qib7 8101 5 to to TO cord-005453-4057qib7 8101 6 have have VB cord-005453-4057qib7 8101 7 higher high JJR cord-005453-4057qib7 8101 8 risk risk NN cord-005453-4057qib7 8101 9 of of IN cord-005453-4057qib7 8101 10 premature premature JJ cord-005453-4057qib7 8101 11 arterial arterial JJ cord-005453-4057qib7 8101 12 disease disease NN cord-005453-4057qib7 8101 13 ( ( -LRB- cord-005453-4057qib7 8101 14 PAD pad NN cord-005453-4057qib7 8101 15 ) ) -RRB- cord-005453-4057qib7 8101 16 at at IN cord-005453-4057qib7 8101 17 6.8 6.8 CD cord-005453-4057qib7 8101 18 % % NN cord-005453-4057qib7 8101 19 compared compare VBN cord-005453-4057qib7 8101 20 to to IN cord-005453-4057qib7 8101 21 the the DT cord-005453-4057qib7 8101 22 general general JJ cord-005453-4057qib7 8101 23 population population NN cord-005453-4057qib7 8101 24 , , , cord-005453-4057qib7 8101 25 however however RB cord-005453-4057qib7 8101 26 GVHD GVHD NNP cord-005453-4057qib7 8101 27 or or CC cord-005453-4057qib7 8101 28 the the DT cord-005453-4057qib7 8101 29 addition addition NN cord-005453-4057qib7 8101 30 of of IN cord-005453-4057qib7 8101 31 TBI TBI NNP cord-005453-4057qib7 8101 32 to to IN cord-005453-4057qib7 8101 33 the the DT cord-005453-4057qib7 8101 34 conditioning conditioning NN cord-005453-4057qib7 8101 35 regimen regimen NN cord-005453-4057qib7 8101 36 were be VBD cord-005453-4057qib7 8101 37 not not RB cord-005453-4057qib7 8101 38 found find VBN cord-005453-4057qib7 8101 39 to to TO cord-005453-4057qib7 8101 40 be be VB cord-005453-4057qib7 8101 41 significantly significantly RB cord-005453-4057qib7 8101 42 associated associate VBN cord-005453-4057qib7 8101 43 with with IN cord-005453-4057qib7 8101 44 PAD pad NN cord-005453-4057qib7 8101 45 . . . cord-005453-4057qib7 8102 1 Regarding regard VBG cord-005453-4057qib7 8102 2 the the DT cord-005453-4057qib7 8102 3 risk risk NN cord-005453-4057qib7 8102 4 of of IN cord-005453-4057qib7 8102 5 new new JJ cord-005453-4057qib7 8102 6 cancers cancer NNS cord-005453-4057qib7 8102 7 , , , cord-005453-4057qib7 8102 8 the the DT cord-005453-4057qib7 8102 9 cumulative cumulative JJ cord-005453-4057qib7 8102 10 incidence incidence NN cord-005453-4057qib7 8102 11 of of IN cord-005453-4057qib7 8102 12 their -PRON- PRP$ cord-005453-4057qib7 8102 13 development development NN cord-005453-4057qib7 8102 14 at at IN cord-005453-4057qib7 8102 15 5 5 CD cord-005453-4057qib7 8102 16 and and CC cord-005453-4057qib7 8102 17 10 10 CD cord-005453-4057qib7 8102 18 years year NNS cord-005453-4057qib7 8102 19 was be VBD cord-005453-4057qib7 8102 20 1.71 1.71 CD cord-005453-4057qib7 8102 21 , , , cord-005453-4057qib7 8102 22 and and CC cord-005453-4057qib7 8102 23 3.61 3.61 CD cord-005453-4057qib7 8102 24 , , , cord-005453-4057qib7 8102 25 respectively respectively RB cord-005453-4057qib7 8102 26 . . . cord-005453-4057qib7 8103 1 Increased increase VBN cord-005453-4057qib7 8103 2 risks risk NNS cord-005453-4057qib7 8103 3 compared compare VBN cord-005453-4057qib7 8103 4 with with IN cord-005453-4057qib7 8103 5 the the DT cord-005453-4057qib7 8103 6 general general JJ cord-005453-4057qib7 8103 7 population population NN cord-005453-4057qib7 8103 8 were be VBD cord-005453-4057qib7 8103 9 seen see VBN cord-005453-4057qib7 8103 10 for for IN cord-005453-4057qib7 8103 11 some some DT cord-005453-4057qib7 8103 12 solid solid JJ cord-005453-4057qib7 8103 13 cancer cancer NN cord-005453-4057qib7 8103 14 including include VBG cord-005453-4057qib7 8103 15 cancers cancer NNS cord-005453-4057qib7 8103 16 of of IN cord-005453-4057qib7 8103 17 the the DT cord-005453-4057qib7 8103 18 lip lip NN cord-005453-4057qib7 8103 19 : : : cord-005453-4057qib7 8103 20 P=0.02 p=0.02 NN cord-005453-4057qib7 8103 21 , , , cord-005453-4057qib7 8103 22 tonsils tonsil NNS cord-005453-4057qib7 8103 23 : : : cord-005453-4057qib7 8104 1 P=0.05 P=0.05 NNP cord-005453-4057qib7 8104 2 , , , cord-005453-4057qib7 8104 3 oropharynx oropharynx NN cord-005453-4057qib7 8104 4 : : : cord-005453-4057qib7 8105 1 P p NN cord-005453-4057qib7 8105 2 < < XX cord-005453-4057qib7 8105 3 0.01 0.01 CD cord-005453-4057qib7 8106 1 , , , cord-005453-4057qib7 8106 2 bone bone NN cord-005453-4057qib7 8106 3 : : : cord-005453-4057qib7 8106 4 P p NN cord-005453-4057qib7 8106 5 < < XX cord-005453-4057qib7 8106 6 0.01 0.01 CD cord-005453-4057qib7 8106 7 , , , cord-005453-4057qib7 8106 8 soft soft JJ cord-005453-4057qib7 8106 9 tissue tissue NN cord-005453-4057qib7 8106 10 : : : cord-005453-4057qib7 8107 1 P p NN cord-005453-4057qib7 8107 2 < < XX cord-005453-4057qib7 8107 3 0.01 0.01 CD cord-005453-4057qib7 8107 4 , , , cord-005453-4057qib7 8107 5 and and CC cord-005453-4057qib7 8107 6 vulva vulva NN cord-005453-4057qib7 8107 7 : : : cord-005453-4057qib7 8107 8 P=0.01 p=0.01 ADD cord-005453-4057qib7 8107 9 . . . cord-005453-4057qib7 8108 1 With with IN cord-005453-4057qib7 8108 2 respect respect NN cord-005453-4057qib7 8108 3 to to IN cord-005453-4057qib7 8108 4 mental mental JJ cord-005453-4057qib7 8108 5 health health NN cord-005453-4057qib7 8108 6 , , , cord-005453-4057qib7 8108 7 depression depression NN cord-005453-4057qib7 8108 8 was be VBD cord-005453-4057qib7 8108 9 prevalent prevalent JJ cord-005453-4057qib7 8108 10 in in IN cord-005453-4057qib7 8108 11 ( ( -LRB- cord-005453-4057qib7 8108 12 10.8 10.8 CD cord-005453-4057qib7 8108 13 % % NN cord-005453-4057qib7 8108 14 ) ) -RRB- cord-005453-4057qib7 8108 15 survivors survivor NNS cord-005453-4057qib7 8108 16 , , , cord-005453-4057qib7 8108 17 in in IN cord-005453-4057qib7 8108 18 whom whom WP cord-005453-4057qib7 8108 19 ( ( -LRB- cord-005453-4057qib7 8108 20 82.5 82.5 CD cord-005453-4057qib7 8108 21 % % NN cord-005453-4057qib7 8108 22 ) ) -RRB- cord-005453-4057qib7 8108 23 were be VBD cord-005453-4057qib7 8108 24 still still RB cord-005453-4057qib7 8108 25 on on IN cord-005453-4057qib7 8108 26 antidepressants antidepressant NNS cord-005453-4057qib7 8108 27 at at IN cord-005453-4057qib7 8108 28 the the DT cord-005453-4057qib7 8108 29 last last JJ cord-005453-4057qib7 8108 30 follow follow NN cord-005453-4057qib7 8108 31 - - HYPH cord-005453-4057qib7 8108 32 up up NN cord-005453-4057qib7 8108 33 . . . cord-005453-4057qib7 8109 1 Cognitive cognitive JJ cord-005453-4057qib7 8109 2 impairment impairment NN cord-005453-4057qib7 8109 3 and and CC cord-005453-4057qib7 8109 4 other other JJ cord-005453-4057qib7 8109 5 psychiatric psychiatric JJ cord-005453-4057qib7 8109 6 disorders disorder NNS cord-005453-4057qib7 8109 7 were be VBD cord-005453-4057qib7 8109 8 found find VBN cord-005453-4057qib7 8109 9 in in IN cord-005453-4057qib7 8109 10 ( ( -LRB- cord-005453-4057qib7 8109 11 2.4 2.4 CD cord-005453-4057qib7 8109 12 % % NN cord-005453-4057qib7 8109 13 ) ) -RRB- cord-005453-4057qib7 8109 14 and and CC cord-005453-4057qib7 8109 15 ( ( -LRB- cord-005453-4057qib7 8109 16 2.7 2.7 CD cord-005453-4057qib7 8109 17 % % NN cord-005453-4057qib7 8109 18 ) ) -RRB- cord-005453-4057qib7 8109 19 survivors survivor NNS cord-005453-4057qib7 8109 20 , , , cord-005453-4057qib7 8109 21 respectively respectively RB cord-005453-4057qib7 8109 22 . . . cord-005453-4057qib7 8110 1 The the DT cord-005453-4057qib7 8110 2 most most RBS cord-005453-4057qib7 8110 3 common common JJ cord-005453-4057qib7 8110 4 cause cause NN cord-005453-4057qib7 8110 5 of of IN cord-005453-4057qib7 8110 6 NRM NRM NNP cord-005453-4057qib7 8110 7 in in IN cord-005453-4057qib7 8110 8 the the DT cord-005453-4057qib7 8110 9 first first JJ cord-005453-4057qib7 8110 10 5 5 CD cord-005453-4057qib7 8110 11 years year NNS cord-005453-4057qib7 8110 12 was be VBD cord-005453-4057qib7 8110 13 GVHD GVHD NNP cord-005453-4057qib7 8110 14 . . . cord-005453-4057qib7 8111 1 However however RB cord-005453-4057qib7 8111 2 , , , cord-005453-4057qib7 8111 3 after after IN cord-005453-4057qib7 8111 4 10 10 CD cord-005453-4057qib7 8111 5 years year NNS cord-005453-4057qib7 8111 6 , , , cord-005453-4057qib7 8111 7 the the DT cord-005453-4057qib7 8111 8 leading lead VBG cord-005453-4057qib7 8111 9 cause cause NN cord-005453-4057qib7 8111 10 of of IN cord-005453-4057qib7 8111 11 death death NN cord-005453-4057qib7 8111 12 in in IN cord-005453-4057qib7 8111 13 those those DT cord-005453-4057qib7 8111 14 conditioned condition VBN cord-005453-4057qib7 8111 15 with with IN cord-005453-4057qib7 8111 16 MAC MAC NNP cord-005453-4057qib7 8111 17 regimen regimen NN cord-005453-4057qib7 8111 18 was be VBD cord-005453-4057qib7 8111 19 secondary secondary JJ cord-005453-4057qib7 8111 20 cancer cancer NN cord-005453-4057qib7 8111 21 , , , cord-005453-4057qib7 8111 22 but but CC cord-005453-4057qib7 8111 23 in in IN cord-005453-4057qib7 8111 24 the the DT cord-005453-4057qib7 8111 25 RIC RIC NNP cord-005453-4057qib7 8111 26 group group NN cord-005453-4057qib7 8111 27 , , , cord-005453-4057qib7 8111 28 new new JJ cord-005453-4057qib7 8111 29 cancers cancer NNS cord-005453-4057qib7 8111 30 and and CC cord-005453-4057qib7 8111 31 GVHD GVHD NNP cord-005453-4057qib7 8111 32 contributed contribute VBD cord-005453-4057qib7 8111 33 equally equally RB cord-005453-4057qib7 8111 34 . . . cord-005453-4057qib7 8112 1 Conclusions conclusion NNS cord-005453-4057qib7 8112 2 : : : cord-005453-4057qib7 8113 1 HCT HCT NNP cord-005453-4057qib7 8113 2 survivors survivor NNS cord-005453-4057qib7 8113 3 remain remain VBP cord-005453-4057qib7 8113 4 at at IN cord-005453-4057qib7 8113 5 risk risk NN cord-005453-4057qib7 8113 6 of of IN cord-005453-4057qib7 8113 7 significant significant JJ cord-005453-4057qib7 8113 8 complications complication NNS cord-005453-4057qib7 8113 9 which which WDT cord-005453-4057qib7 8113 10 lead lead VBP cord-005453-4057qib7 8113 11 to to IN cord-005453-4057qib7 8113 12 premature premature JJ cord-005453-4057qib7 8113 13 death death NN cord-005453-4057qib7 8113 14 and and CC cord-005453-4057qib7 8113 15 their -PRON- PRP$ cord-005453-4057qib7 8113 16 burden burden NN cord-005453-4057qib7 8113 17 of of IN cord-005453-4057qib7 8113 18 comorbidities comorbiditie NNS cord-005453-4057qib7 8113 19 at at IN cord-005453-4057qib7 8113 20 the the DT cord-005453-4057qib7 8113 21 end end NN cord-005453-4057qib7 8113 22 of of IN cord-005453-4057qib7 8113 23 life life NN cord-005453-4057qib7 8113 24 is be VBZ cord-005453-4057qib7 8113 25 significantly significantly RB cord-005453-4057qib7 8113 26 more more JJR cord-005453-4057qib7 8113 27 than than IN cord-005453-4057qib7 8113 28 that that DT cord-005453-4057qib7 8113 29 of of IN cord-005453-4057qib7 8113 30 general general JJ cord-005453-4057qib7 8113 31 population population NN cord-005453-4057qib7 8113 32 . . . cord-005453-4057qib7 8114 1 Background background NN cord-005453-4057qib7 8114 2 : : : cord-005453-4057qib7 8115 1 Late late JJ cord-005453-4057qib7 8115 2 onset onset NN cord-005453-4057qib7 8115 3 Hemorrhagic hemorrhagic JJ cord-005453-4057qib7 8115 4 cystitis cystitis NN cord-005453-4057qib7 8115 5 ( ( -LRB- cord-005453-4057qib7 8115 6 HC HC NNP cord-005453-4057qib7 8115 7 ) ) -RRB- cord-005453-4057qib7 8115 8 is be VBZ cord-005453-4057qib7 8115 9 a a DT cord-005453-4057qib7 8115 10 common common JJ cord-005453-4057qib7 8115 11 complication complication NN cord-005453-4057qib7 8115 12 of of IN cord-005453-4057qib7 8115 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 8115 14 stem stem NN cord-005453-4057qib7 8115 15 cell cell NN cord-005453-4057qib7 8115 16 transplantation transplantation NN cord-005453-4057qib7 8115 17 ( ( -LRB- cord-005453-4057qib7 8115 18 HSCT HSCT NNP cord-005453-4057qib7 8115 19 ) ) -RRB- cord-005453-4057qib7 8115 20 frequently frequently RB cord-005453-4057qib7 8115 21 associated associate VBN cord-005453-4057qib7 8115 22 with with IN cord-005453-4057qib7 8115 23 reactivation reactivation NN cord-005453-4057qib7 8115 24 of of IN cord-005453-4057qib7 8115 25 BK BK NNP cord-005453-4057qib7 8115 26 virus virus NN cord-005453-4057qib7 8115 27 ( ( -LRB- cord-005453-4057qib7 8115 28 BK BK NNP cord-005453-4057qib7 8115 29 - - HYPH cord-005453-4057qib7 8115 30 HC).There HC).There NNP cord-005453-4057qib7 8115 31 is be VBZ cord-005453-4057qib7 8115 32 no no DT cord-005453-4057qib7 8115 33 consensus consensus NN cord-005453-4057qib7 8115 34 as as IN cord-005453-4057qib7 8115 35 to to IN cord-005453-4057qib7 8115 36 the the DT cord-005453-4057qib7 8115 37 best good JJS cord-005453-4057qib7 8115 38 therapy therapy NN cord-005453-4057qib7 8115 39 for for IN cord-005453-4057qib7 8115 40 BK BK NNP cord-005453-4057qib7 8115 41 - - HYPH cord-005453-4057qib7 8115 42 HC HC NNP cord-005453-4057qib7 8115 43 , , , cord-005453-4057qib7 8115 44 and and CC cord-005453-4057qib7 8115 45 many many JJ cord-005453-4057qib7 8115 46 different different JJ cord-005453-4057qib7 8115 47 treatments treatment NNS cord-005453-4057qib7 8115 48 have have VBP cord-005453-4057qib7 8115 49 been be VBN cord-005453-4057qib7 8115 50 reported report VBN cord-005453-4057qib7 8115 51 . . . cord-005453-4057qib7 8116 1 Hyper hyper JJ cord-005453-4057qib7 8116 2 baric baric NN cord-005453-4057qib7 8116 3 oxygen oxygen NN cord-005453-4057qib7 8116 4 therapy therapy NN cord-005453-4057qib7 8116 5 ( ( -LRB- cord-005453-4057qib7 8116 6 HBOT HBOT NNP cord-005453-4057qib7 8116 7 ) ) -RRB- cord-005453-4057qib7 8116 8 is be VBZ cord-005453-4057qib7 8116 9 used use VBN cord-005453-4057qib7 8116 10 as as IN cord-005453-4057qib7 8116 11 primary primary JJ cord-005453-4057qib7 8116 12 or or CC cord-005453-4057qib7 8116 13 adjuvant adjuvant JJ cord-005453-4057qib7 8116 14 therapy therapy NN cord-005453-4057qib7 8116 15 in in IN cord-005453-4057qib7 8116 16 diverse diverse JJ cord-005453-4057qib7 8116 17 clinical clinical JJ cord-005453-4057qib7 8116 18 situations situation NNS cord-005453-4057qib7 8116 19 involving involve VBG cord-005453-4057qib7 8116 20 hypoxic hypoxic JJ cord-005453-4057qib7 8116 21 injury injury NN cord-005453-4057qib7 8116 22 to to IN cord-005453-4057qib7 8116 23 tissues tissue NNS cord-005453-4057qib7 8116 24 and and CC cord-005453-4057qib7 8116 25 has have VBZ cord-005453-4057qib7 8116 26 been be VBN cord-005453-4057qib7 8116 27 explored explore VBN cord-005453-4057qib7 8116 28 as as IN cord-005453-4057qib7 8116 29 a a DT cord-005453-4057qib7 8116 30 useful useful JJ cord-005453-4057qib7 8116 31 tool tool NN cord-005453-4057qib7 8116 32 in in IN cord-005453-4057qib7 8116 33 treating treat VBG cord-005453-4057qib7 8116 34 BK BK NNP cord-005453-4057qib7 8116 35 -HC -HC NNP cord-005453-4057qib7 8116 36 . . . cord-005453-4057qib7 8117 1 We -PRON- PRP cord-005453-4057qib7 8117 2 report report VBP cord-005453-4057qib7 8117 3 our -PRON- PRP$ cord-005453-4057qib7 8117 4 experience experience NN cord-005453-4057qib7 8117 5 with with IN cord-005453-4057qib7 8117 6 HBOT HBOT NNP cord-005453-4057qib7 8117 7 in in IN cord-005453-4057qib7 8117 8 combination combination NN cord-005453-4057qib7 8117 9 with with IN cord-005453-4057qib7 8117 10 non non JJ cord-005453-4057qib7 8117 11 - - JJ cord-005453-4057qib7 8117 12 invasive invasive JJ cord-005453-4057qib7 8117 13 supportive supportive JJ cord-005453-4057qib7 8117 14 care care NN cord-005453-4057qib7 8117 15 in in IN cord-005453-4057qib7 8117 16 children child NNS cord-005453-4057qib7 8117 17 and and CC cord-005453-4057qib7 8117 18 adolescents adolescent NNS cord-005453-4057qib7 8117 19 suffering suffer VBG cord-005453-4057qib7 8117 20 from from IN cord-005453-4057qib7 8117 21 BK BK NNP cord-005453-4057qib7 8117 22 - - HYPH cord-005453-4057qib7 8117 23 HC HC NNP cord-005453-4057qib7 8117 24 following follow VBG cord-005453-4057qib7 8117 25 allogeneic allogeneic IN cord-005453-4057qib7 8117 26 HSCT HSCT NNP cord-005453-4057qib7 8117 27 . . . cord-005453-4057qib7 8118 1 Methods method NNS cord-005453-4057qib7 8118 2 : : : cord-005453-4057qib7 8119 1 The the DT cord-005453-4057qib7 8119 2 computerized computerized JJ cord-005453-4057qib7 8119 3 database database NN cord-005453-4057qib7 8119 4 of of IN cord-005453-4057qib7 8119 5 Schneider Schneider NNP cord-005453-4057qib7 8119 6 Children´s Children´s NNP cord-005453-4057qib7 8119 7 Medical Medical NNP cord-005453-4057qib7 8119 8 Center Center NNP cord-005453-4057qib7 8119 9 of of IN cord-005453-4057qib7 8119 10 Israel Israel NNP cord-005453-4057qib7 8119 11 was be VBD cord-005453-4057qib7 8119 12 reviewed review VBN cord-005453-4057qib7 8119 13 for for IN cord-005453-4057qib7 8119 14 all all DT cord-005453-4057qib7 8119 15 patients patient NNS cord-005453-4057qib7 8119 16 aged aged JJ cord-005453-4057qib7 8119 17 0 0 CD cord-005453-4057qib7 8119 18 to to IN cord-005453-4057qib7 8119 19 21 21 CD cord-005453-4057qib7 8119 20 years year NNS cord-005453-4057qib7 8119 21 who who WP cord-005453-4057qib7 8119 22 underwent undergo VBD cord-005453-4057qib7 8119 23 HSCT HSCT NNP cord-005453-4057qib7 8119 24 between between IN cord-005453-4057qib7 8119 25 January January NNP cord-005453-4057qib7 8119 26 2000 2000 CD cord-005453-4057qib7 8119 27 and and CC cord-005453-4057qib7 8119 28 June June NNP cord-005453-4057qib7 8119 29 2018 2018 CD cord-005453-4057qib7 8119 30 and and CC cord-005453-4057qib7 8119 31 developed develop VBD cord-005453-4057qib7 8119 32 BK BK NNP cord-005453-4057qib7 8119 33 - - HYPH cord-005453-4057qib7 8119 34 HC HC NNP cord-005453-4057qib7 8119 35 . . . cord-005453-4057qib7 8120 1 HBOT HBOT NNP cord-005453-4057qib7 8120 2 therapy therapy NN cord-005453-4057qib7 8120 3 consisted consist VBD cord-005453-4057qib7 8120 4 of of IN cord-005453-4057qib7 8120 5 2 2 CD cord-005453-4057qib7 8120 6 hours hour NNS cord-005453-4057qib7 8120 7 sessions session NNS cord-005453-4057qib7 8120 8 at at IN cord-005453-4057qib7 8120 9 2 2 CD cord-005453-4057qib7 8120 10 atmospheres atmosphere NNS cord-005453-4057qib7 8120 11 , , , cord-005453-4057qib7 8120 12 with with IN cord-005453-4057qib7 8120 13 patients patient NNS cord-005453-4057qib7 8120 14 breathing breathe VBG cord-005453-4057qib7 8120 15 oxygen oxygen NN cord-005453-4057qib7 8120 16 by by IN cord-005453-4057qib7 8120 17 mask mask NN cord-005453-4057qib7 8120 18 . . . cord-005453-4057qib7 8121 1 Parents parent NNS cord-005453-4057qib7 8121 2 accompanied accompany VBD cord-005453-4057qib7 8121 3 patients patient NNS cord-005453-4057qib7 8121 4 during during IN cord-005453-4057qib7 8121 5 the the DT cord-005453-4057qib7 8121 6 treatment treatment NN cord-005453-4057qib7 8121 7 . . . cord-005453-4057qib7 8122 1 Results result NNS cord-005453-4057qib7 8122 2 : : : cord-005453-4057qib7 8123 1 Fourteen fourteen CD cord-005453-4057qib7 8123 2 patients patient NNS cord-005453-4057qib7 8123 3 with with IN cord-005453-4057qib7 8123 4 a a DT cord-005453-4057qib7 8123 5 variety variety NN cord-005453-4057qib7 8123 6 of of IN cord-005453-4057qib7 8123 7 underlying underlie VBG cord-005453-4057qib7 8123 8 diseases disease NNS cord-005453-4057qib7 8123 9 received receive VBN cord-005453-4057qib7 8123 10 ( ( -LRB- cord-005453-4057qib7 8123 11 HBOT HBOT NNP cord-005453-4057qib7 8123 12 ) ) -RRB- cord-005453-4057qib7 8123 13 for for IN cord-005453-4057qib7 8123 14 treatment treatment NN cord-005453-4057qib7 8123 15 of of IN cord-005453-4057qib7 8123 16 BK BK NNP cord-005453-4057qib7 8123 17 - - HYPH cord-005453-4057qib7 8123 18 HC HC NNP cord-005453-4057qib7 8123 19 following follow VBG cord-005453-4057qib7 8123 20 HSCT HSCT NNP cord-005453-4057qib7 8123 21 . . . cord-005453-4057qib7 8124 1 The the DT cord-005453-4057qib7 8124 2 initial initial JJ cord-005453-4057qib7 8124 3 treatment treatment NN cord-005453-4057qib7 8124 4 for for IN cord-005453-4057qib7 8124 5 children child NNS cord-005453-4057qib7 8124 6 with with IN cord-005453-4057qib7 8124 7 BK BK NNP cord-005453-4057qib7 8124 8 - - HYPH cord-005453-4057qib7 8124 9 HC HC NNP cord-005453-4057qib7 8124 10 at at IN cord-005453-4057qib7 8124 11 our -PRON- PRP$ cord-005453-4057qib7 8124 12 center center NN cord-005453-4057qib7 8124 13 prior prior RB cord-005453-4057qib7 8124 14 to to IN cord-005453-4057qib7 8124 15 2008 2008 CD cord-005453-4057qib7 8124 16 included include VBD cord-005453-4057qib7 8124 17 continuous continuous JJ cord-005453-4057qib7 8124 18 bladder bladder NN cord-005453-4057qib7 8124 19 irrigation irrigation NN cord-005453-4057qib7 8124 20 and and CC cord-005453-4057qib7 8124 21 intravesicular intravesicular JJ cord-005453-4057qib7 8124 22 instillation instillation NN cord-005453-4057qib7 8124 23 of of IN cord-005453-4057qib7 8124 24 various various JJ cord-005453-4057qib7 8124 25 medications medication NNS cord-005453-4057qib7 8124 26 . . . cord-005453-4057qib7 8125 1 Beginning begin VBG cord-005453-4057qib7 8125 2 in in IN cord-005453-4057qib7 8125 3 2008 2008 CD cord-005453-4057qib7 8125 4 , , , cord-005453-4057qib7 8125 5 we -PRON- PRP cord-005453-4057qib7 8125 6 adopted adopt VBD cord-005453-4057qib7 8125 7 a a DT cord-005453-4057qib7 8125 8 non non JJ cord-005453-4057qib7 8125 9 - - JJ cord-005453-4057qib7 8125 10 invasive invasive JJ cord-005453-4057qib7 8125 11 strategy strategy NN cord-005453-4057qib7 8125 12 that that WDT cord-005453-4057qib7 8125 13 included include VBD cord-005453-4057qib7 8125 14 the the DT cord-005453-4057qib7 8125 15 administration administration NN cord-005453-4057qib7 8125 16 of of IN cord-005453-4057qib7 8125 17 oral oral JJ cord-005453-4057qib7 8125 18 anticholinergics anticholinergics NNPS cord-005453-4057qib7 8125 19 ( ( -LRB- cord-005453-4057qib7 8125 20 oxybutinin oxybutinin NNP cord-005453-4057qib7 8125 21 ) ) -RRB- cord-005453-4057qib7 8125 22 , , , cord-005453-4057qib7 8125 23 systemic systemic JJ cord-005453-4057qib7 8125 24 pain pain NN cord-005453-4057qib7 8125 25 management management NN cord-005453-4057qib7 8125 26 , , , cord-005453-4057qib7 8125 27 hyperhydration hyperhydration NN cord-005453-4057qib7 8125 28 and and CC cord-005453-4057qib7 8125 29 the the DT cord-005453-4057qib7 8125 30 administration administration NN cord-005453-4057qib7 8125 31 of of IN cord-005453-4057qib7 8125 32 weekly weekly JJ cord-005453-4057qib7 8125 33 Cidofovir Cidofovir NNPS cord-005453-4057qib7 8125 34 with with IN cord-005453-4057qib7 8125 35 Probenecid Probenecid NNP cord-005453-4057qib7 8125 36 . . . cord-005453-4057qib7 8126 1 HBOT HBOT NNP cord-005453-4057qib7 8126 2 was be VBD cord-005453-4057qib7 8126 3 administered administer VBN cord-005453-4057qib7 8126 4 to to IN cord-005453-4057qib7 8126 5 patients patient NNS cord-005453-4057qib7 8126 6 who who WP cord-005453-4057qib7 8126 7 failed fail VBD cord-005453-4057qib7 8126 8 the the DT cord-005453-4057qib7 8126 9 above above JJ cord-005453-4057qib7 8126 10 regimen regimen NN cord-005453-4057qib7 8126 11 . . . cord-005453-4057qib7 8127 1 With with IN cord-005453-4057qib7 8127 2 this this DT cord-005453-4057qib7 8127 3 protocol protocol NN cord-005453-4057qib7 8127 4 , , , cord-005453-4057qib7 8127 5 the the DT cord-005453-4057qib7 8127 6 average average JJ cord-005453-4057qib7 8127 7 time time NN cord-005453-4057qib7 8127 8 of of IN cord-005453-4057qib7 8127 9 starting start VBG cord-005453-4057qib7 8127 10 HBOT HBOT NNP cord-005453-4057qib7 8127 11 dropped drop VBD cord-005453-4057qib7 8127 12 from from IN cord-005453-4057qib7 8127 13 13 13 CD cord-005453-4057qib7 8127 14 ( ( -LRB- cord-005453-4057qib7 8127 15 prior prior RB cord-005453-4057qib7 8127 16 to to IN cord-005453-4057qib7 8127 17 2008 2008 CD cord-005453-4057qib7 8127 18 ) ) -RRB- cord-005453-4057qib7 8127 19 to to IN cord-005453-4057qib7 8127 20 9.8 9.8 CD cord-005453-4057qib7 8127 21 days day NNS cord-005453-4057qib7 8127 22 . . . cord-005453-4057qib7 8128 1 The the DT cord-005453-4057qib7 8128 2 median median JJ cord-005453-4057qib7 8128 3 onset onset NN cord-005453-4057qib7 8128 4 of of IN cord-005453-4057qib7 8128 5 HC HC NNP cord-005453-4057qib7 8128 6 was be VBD cord-005453-4057qib7 8129 1 33 33 CD cord-005453-4057qib7 8129 2 days day NNS cord-005453-4057qib7 8129 3 post post NN cord-005453-4057qib7 8129 4 HSCT HSCT NNP cord-005453-4057qib7 8129 5 . . . cord-005453-4057qib7 8130 1 All all DT cord-005453-4057qib7 8130 2 patients patient NNS cord-005453-4057qib7 8130 3 were be VBD cord-005453-4057qib7 8130 4 receiving receive VBG cord-005453-4057qib7 8130 5 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 8130 6 treatment treatment NN cord-005453-4057qib7 8130 7 at at IN cord-005453-4057qib7 8130 8 the the DT cord-005453-4057qib7 8130 9 onset onset NN cord-005453-4057qib7 8130 10 of of IN cord-005453-4057qib7 8130 11 BK BK NNP cord-005453-4057qib7 8130 12 - - HYPH cord-005453-4057qib7 8130 13 HC HC NNP cord-005453-4057qib7 8130 14 . . . cord-005453-4057qib7 8131 1 All all DT cord-005453-4057qib7 8131 2 patients patient NNS cord-005453-4057qib7 8131 3 suffered suffer VBD cord-005453-4057qib7 8131 4 from from IN cord-005453-4057qib7 8131 5 macrohematuria macrohematuria NNP cord-005453-4057qib7 8131 6 with with IN cord-005453-4057qib7 8131 7 blood blood NN cord-005453-4057qib7 8131 8 clots clot NNS cord-005453-4057qib7 8131 9 ( ( -LRB- cord-005453-4057qib7 8131 10 grade grade NN cord-005453-4057qib7 8131 11 III iii CD cord-005453-4057qib7 8131 12 cystitis cystitis NNP cord-005453-4057qib7 8131 13 ) ) -RRB- cord-005453-4057qib7 8131 14 , , , cord-005453-4057qib7 8131 15 12 12 CD cord-005453-4057qib7 8131 16 ( ( -LRB- cord-005453-4057qib7 8131 17 92.3 92.3 CD cord-005453-4057qib7 8131 18 % % NN cord-005453-4057qib7 8131 19 ) ) -RRB- cord-005453-4057qib7 8131 20 experienced experience VBD cord-005453-4057qib7 8131 21 severe severe JJ cord-005453-4057qib7 8131 22 dysuria dysuria NNS cord-005453-4057qib7 8131 23 and and CC cord-005453-4057qib7 8131 24 11 11 CD cord-005453-4057qib7 8131 25 ( ( -LRB- cord-005453-4057qib7 8131 26 84.6 84.6 CD cord-005453-4057qib7 8131 27 % % NN cord-005453-4057qib7 8131 28 ) ) -RRB- cord-005453-4057qib7 8131 29 urgency urgency NN cord-005453-4057qib7 8131 30 . . . cord-005453-4057qib7 8132 1 BK BK NNP cord-005453-4057qib7 8132 2 viruria viruria NNP cord-005453-4057qib7 8132 3 was be VBD cord-005453-4057qib7 8132 4 present present JJ cord-005453-4057qib7 8132 5 in in IN cord-005453-4057qib7 8132 6 all all DT cord-005453-4057qib7 8132 7 patients patient NNS cord-005453-4057qib7 8132 8 , , , cord-005453-4057qib7 8132 9 and and CC cord-005453-4057qib7 8132 10 concurrent concurrent JJ cord-005453-4057qib7 8132 11 BK BK NNP cord-005453-4057qib7 8132 12 viremia viremia NN cord-005453-4057qib7 8132 13 was be VBD cord-005453-4057qib7 8132 14 detected detect VBN cord-005453-4057qib7 8132 15 in in IN cord-005453-4057qib7 8132 16 80 80 CD cord-005453-4057qib7 8132 17 % % NN cord-005453-4057qib7 8132 18 of of IN cord-005453-4057qib7 8132 19 those those DT cord-005453-4057qib7 8132 20 who who WP cord-005453-4057qib7 8132 21 were be VBD cord-005453-4057qib7 8132 22 tested test VBN cord-005453-4057qib7 8132 23 . . . cord-005453-4057qib7 8133 1 Patients patient NNS cord-005453-4057qib7 8133 2 reported report VBD cord-005453-4057qib7 8133 3 symptomatic symptomatic JJ cord-005453-4057qib7 8133 4 improvement improvement NN cord-005453-4057qib7 8133 5 at at IN cord-005453-4057qib7 8133 6 a a DT cord-005453-4057qib7 8133 7 mean mean NN cord-005453-4057qib7 8133 8 of of IN cord-005453-4057qib7 8133 9 3.6 3.6 CD cord-005453-4057qib7 8133 10 days day NNS cord-005453-4057qib7 8133 11 following follow VBG cord-005453-4057qib7 8133 12 the the DT cord-005453-4057qib7 8133 13 initiation initiation NN cord-005453-4057qib7 8133 14 of of IN cord-005453-4057qib7 8133 15 HBOT HBOT NNP cord-005453-4057qib7 8133 16 . . . cord-005453-4057qib7 8134 1 No no DT cord-005453-4057qib7 8134 2 patient patient NN cord-005453-4057qib7 8134 3 experienced experience VBD cord-005453-4057qib7 8134 4 serious serious JJ cord-005453-4057qib7 8134 5 adverse adverse JJ cord-005453-4057qib7 8134 6 effects effect NNS cord-005453-4057qib7 8134 7 due due IN cord-005453-4057qib7 8134 8 to to IN cord-005453-4057qib7 8134 9 HBOT HBOT NNP cord-005453-4057qib7 8134 10 , , , cord-005453-4057qib7 8134 11 but but CC cord-005453-4057qib7 8134 12 two two CD cord-005453-4057qib7 8134 13 patients patient NNS cord-005453-4057qib7 8134 14 required require VBD cord-005453-4057qib7 8134 15 insertion insertion NN cord-005453-4057qib7 8134 16 of of IN cord-005453-4057qib7 8134 17 tympanic tympanic JJ cord-005453-4057qib7 8134 18 ventilation ventilation NN cord-005453-4057qib7 8134 19 tubes tube NNS cord-005453-4057qib7 8134 20 . . . cord-005453-4057qib7 8135 1 Eleven eleven CD cord-005453-4057qib7 8135 2 of of IN cord-005453-4057qib7 8135 3 our -PRON- PRP$ cord-005453-4057qib7 8135 4 13 13 CD cord-005453-4057qib7 8135 5 patients patient NNS cord-005453-4057qib7 8135 6 ( ( -LRB- cord-005453-4057qib7 8135 7 84.6 84.6 CD cord-005453-4057qib7 8135 8 % % NN cord-005453-4057qib7 8135 9 ) ) -RRB- cord-005453-4057qib7 8135 10 experienced experience VBD cord-005453-4057qib7 8135 11 complete complete JJ cord-005453-4057qib7 8135 12 remission remission NN cord-005453-4057qib7 8135 13 of of IN cord-005453-4057qib7 8135 14 BK BK NNP cord-005453-4057qib7 8135 15 - - HYPH cord-005453-4057qib7 8135 16 HC HC NNP cord-005453-4057qib7 8135 17 following follow VBG cord-005453-4057qib7 8135 18 HBOT HBOT NNP cord-005453-4057qib7 8135 19 , , , cord-005453-4057qib7 8135 20 with with IN cord-005453-4057qib7 8135 21 an an DT cord-005453-4057qib7 8135 22 overall overall JJ cord-005453-4057qib7 8135 23 response response NN cord-005453-4057qib7 8135 24 rate rate NN cord-005453-4057qib7 8135 25 of of IN cord-005453-4057qib7 8135 26 92.3 92.3 CD cord-005453-4057qib7 8135 27 % % NN cord-005453-4057qib7 8135 28 ( ( -LRB- cord-005453-4057qib7 8135 29 12/13 12/13 CD cord-005453-4057qib7 8135 30 patients).Eight patients).eight NN cord-005453-4057qib7 8135 31 of of IN cord-005453-4057qib7 8135 32 our -PRON- PRP$ cord-005453-4057qib7 8135 33 patients patient NNS cord-005453-4057qib7 8135 34 ( ( -LRB- cord-005453-4057qib7 8135 35 61.5 61.5 CD cord-005453-4057qib7 8135 36 % % NN cord-005453-4057qib7 8135 37 ) ) -RRB- cord-005453-4057qib7 8135 38 eventually eventually RB cord-005453-4057qib7 8135 39 succumbed succumb VBD cord-005453-4057qib7 8135 40 due due JJ cord-005453-4057qib7 8135 41 to to IN cord-005453-4057qib7 8135 42 either either CC cord-005453-4057qib7 8135 43 HSCT HSCT NNP cord-005453-4057qib7 8135 44 complications complication NNS cord-005453-4057qib7 8135 45 or or CC cord-005453-4057qib7 8135 46 disease disease NN cord-005453-4057qib7 8135 47 relapse relapse NN cord-005453-4057qib7 8135 48 . . . cord-005453-4057qib7 8136 1 Conclusions conclusion NNS cord-005453-4057qib7 8136 2 : : : cord-005453-4057qib7 8137 1 Hyperbaric hyperbaric NN cord-005453-4057qib7 8137 2 oxygen oxygen NN cord-005453-4057qib7 8137 3 therapy therapy NN cord-005453-4057qib7 8137 4 is be VBZ cord-005453-4057qib7 8137 5 a a DT cord-005453-4057qib7 8137 6 safe safe JJ cord-005453-4057qib7 8137 7 , , , cord-005453-4057qib7 8137 8 effective effective JJ cord-005453-4057qib7 8137 9 , , , cord-005453-4057qib7 8137 10 non non JJ cord-005453-4057qib7 8137 11 - - JJ cord-005453-4057qib7 8137 12 invasive invasive JJ cord-005453-4057qib7 8137 13 and and CC cord-005453-4057qib7 8137 14 well well RB cord-005453-4057qib7 8137 15 tolerated tolerate VBN cord-005453-4057qib7 8137 16 treatment treatment NN cord-005453-4057qib7 8137 17 modality modality NN cord-005453-4057qib7 8137 18 for for IN cord-005453-4057qib7 8137 19 BK BK NNP cord-005453-4057qib7 8137 20 -HC -HC : cord-005453-4057qib7 8137 21 and and CC cord-005453-4057qib7 8137 22 should should MD cord-005453-4057qib7 8137 23 be be VB cord-005453-4057qib7 8137 24 considered consider VBN cord-005453-4057qib7 8137 25 for for IN cord-005453-4057qib7 8137 26 first first JJ cord-005453-4057qib7 8137 27 line line NN cord-005453-4057qib7 8137 28 therapy therapy NN cord-005453-4057qib7 8137 29 for for IN cord-005453-4057qib7 8137 30 this this DT cord-005453-4057qib7 8137 31 complication complication NN cord-005453-4057qib7 8137 32 of of IN cord-005453-4057qib7 8137 33 HSCT HSCT NNP cord-005453-4057qib7 8137 34 . . . cord-005453-4057qib7 8138 1 Clinical clinical JJ cord-005453-4057qib7 8138 2 Background background NN cord-005453-4057qib7 8138 3 : : : cord-005453-4057qib7 8139 1 Every every DT cord-005453-4057qib7 8139 2 year year NN cord-005453-4057qib7 8139 3 , , , cord-005453-4057qib7 8139 4 almost almost RB cord-005453-4057qib7 8139 5 one one CD cord-005453-4057qib7 8139 6 thousand thousand CD cord-005453-4057qib7 8139 7 cases case NNS cord-005453-4057qib7 8139 8 of of IN cord-005453-4057qib7 8139 9 hematological hematological JJ cord-005453-4057qib7 8139 10 malignancies malignancy NNS cord-005453-4057qib7 8139 11 in in IN cord-005453-4057qib7 8139 12 pediatric pediatric JJ cord-005453-4057qib7 8139 13 population population NN cord-005453-4057qib7 8139 14 are be VBP cord-005453-4057qib7 8139 15 reported report VBN cord-005453-4057qib7 8139 16 in in IN cord-005453-4057qib7 8139 17 Peru Peru NNP cord-005453-4057qib7 8139 18 . . . cord-005453-4057qib7 8140 1 Allogeneic Allogeneic NNP cord-005453-4057qib7 8140 2 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 8140 3 Stem Stem NNP cord-005453-4057qib7 8140 4 Cell cell NN cord-005453-4057qib7 8140 5 Transplantation transplantation NN cord-005453-4057qib7 8140 6 ( ( -LRB- cord-005453-4057qib7 8140 7 allo allo NN cord-005453-4057qib7 8140 8 - - HYPH cord-005453-4057qib7 8140 9 HSCT HSCT NNP cord-005453-4057qib7 8140 10 ) ) -RRB- cord-005453-4057qib7 8140 11 is be VBZ cord-005453-4057qib7 8140 12 an an DT cord-005453-4057qib7 8140 13 alternative alternative JJ cord-005453-4057qib7 8140 14 strategy strategy NN cord-005453-4057qib7 8140 15 in in IN cord-005453-4057qib7 8140 16 many many JJ cord-005453-4057qib7 8140 17 of of IN cord-005453-4057qib7 8140 18 these these DT cord-005453-4057qib7 8140 19 cases case NNS cord-005453-4057qib7 8140 20 . . . cord-005453-4057qib7 8141 1 Only only RB cord-005453-4057qib7 8141 2 between between IN cord-005453-4057qib7 8141 3 20 20 CD cord-005453-4057qib7 8141 4 - - SYM cord-005453-4057qib7 8141 5 30 30 CD cord-005453-4057qib7 8141 6 % % NN cord-005453-4057qib7 8141 7 of of IN cord-005453-4057qib7 8141 8 the the DT cord-005453-4057qib7 8141 9 pediatric pediatric JJ cord-005453-4057qib7 8141 10 population population NN cord-005453-4057qib7 8141 11 that that WDT cord-005453-4057qib7 8141 12 requires require VBZ cord-005453-4057qib7 8141 13 a a DT cord-005453-4057qib7 8141 14 HSCT HSCT NNP cord-005453-4057qib7 8141 15 has have VBZ cord-005453-4057qib7 8141 16 a a DT cord-005453-4057qib7 8141 17 compatible compatible JJ cord-005453-4057qib7 8141 18 Human human JJ cord-005453-4057qib7 8141 19 Leukocyte Leukocyte NNP cord-005453-4057qib7 8141 20 Antigen Antigen NNP cord-005453-4057qib7 8141 21 ( ( -LRB- cord-005453-4057qib7 8141 22 HLA HLA NNP cord-005453-4057qib7 8141 23 ) ) -RRB- cord-005453-4057qib7 8141 24 donor donor NN cord-005453-4057qib7 8141 25 . . . cord-005453-4057qib7 8142 1 The the DT cord-005453-4057qib7 8142 2 remaining remain VBG cord-005453-4057qib7 8142 3 70 70 CD cord-005453-4057qib7 8142 4 % % NN cord-005453-4057qib7 8142 5 have have VBP cord-005453-4057qib7 8142 6 to to TO cord-005453-4057qib7 8142 7 access access VB cord-005453-4057qib7 8142 8 international international JJ cord-005453-4057qib7 8142 9 donor donor NN cord-005453-4057qib7 8142 10 registries registry NNS cord-005453-4057qib7 8142 11 , , , cord-005453-4057qib7 8142 12 extending extend VBG cord-005453-4057qib7 8142 13 the the DT cord-005453-4057qib7 8142 14 awaiting await VBG cord-005453-4057qib7 8142 15 time time NN cord-005453-4057qib7 8142 16 and and CC cord-005453-4057qib7 8142 17 conditioning condition VBG cord-005453-4057qib7 8142 18 the the DT cord-005453-4057qib7 8142 19 progress progress NN cord-005453-4057qib7 8142 20 of of IN cord-005453-4057qib7 8142 21 the the DT cord-005453-4057qib7 8142 22 disease disease NN cord-005453-4057qib7 8142 23 . . . cord-005453-4057qib7 8143 1 Allo Allo NNP cord-005453-4057qib7 8143 2 - - HYPH cord-005453-4057qib7 8143 3 HSCT HSCT NNP cord-005453-4057qib7 8143 4 has have VBZ cord-005453-4057qib7 8143 5 the the DT cord-005453-4057qib7 8143 6 potential potential NN cord-005453-4057qib7 8143 7 to to TO cord-005453-4057qib7 8143 8 help help VB cord-005453-4057qib7 8143 9 children child NNS cord-005453-4057qib7 8143 10 with with IN cord-005453-4057qib7 8143 11 several several JJ cord-005453-4057qib7 8143 12 hematological hematological JJ cord-005453-4057qib7 8143 13 disorders disorder NNS cord-005453-4057qib7 8143 14 with with IN cord-005453-4057qib7 8143 15 non non JJ cord-005453-4057qib7 8143 16 - - JJ cord-005453-4057qib7 8143 17 compatible compatible JJ cord-005453-4057qib7 8143 18 HLA HLA NNP cord-005453-4057qib7 8143 19 donor donor NN cord-005453-4057qib7 8143 20 . . . cord-005453-4057qib7 8144 1 HLA HLA NNP cord-005453-4057qib7 8145 1 genotypically genotypically RB cord-005453-4057qib7 8145 2 identical identical JJ cord-005453-4057qib7 8145 3 sibling sibling NN cord-005453-4057qib7 8145 4 donors donor NNS cord-005453-4057qib7 8145 5 are be VBP cord-005453-4057qib7 8145 6 the the DT cord-005453-4057qib7 8145 7 best good JJS cord-005453-4057qib7 8145 8 option option NN cord-005453-4057qib7 8145 9 when when WRB cord-005453-4057qib7 8145 10 pursuing pursue VBG cord-005453-4057qib7 8145 11 an an DT cord-005453-4057qib7 8145 12 HSCT HSCT NNP cord-005453-4057qib7 8145 13 . . . cord-005453-4057qib7 8146 1 Nevertheless nevertheless RB cord-005453-4057qib7 8146 2 , , , cord-005453-4057qib7 8146 3 patients patient NNS cord-005453-4057qib7 8146 4 ' ' POS cord-005453-4057qib7 8146 5 alternative alternative JJ cord-005453-4057qib7 8146 6 sources source NNS cord-005453-4057qib7 8146 7 of of IN cord-005453-4057qib7 8146 8 stem stem NN cord-005453-4057qib7 8146 9 cells cell NNS cord-005453-4057qib7 8146 10 could could MD cord-005453-4057qib7 8146 11 be be VB cord-005453-4057qib7 8146 12 obtained obtain VBN cord-005453-4057qib7 8146 13 from from IN cord-005453-4057qib7 8146 14 an an DT cord-005453-4057qib7 8146 15 haploidentical haploidentical JJ cord-005453-4057qib7 8146 16 donor donor NN cord-005453-4057qib7 8146 17 like like IN cord-005453-4057qib7 8146 18 one one CD cord-005453-4057qib7 8146 19 of of IN cord-005453-4057qib7 8146 20 their -PRON- PRP$ cord-005453-4057qib7 8146 21 parents parent NNS cord-005453-4057qib7 8146 22 . . . cord-005453-4057qib7 8147 1 The the DT cord-005453-4057qib7 8147 2 Haploidentical Haploidentical NNP cord-005453-4057qib7 8147 3 Transplantation Transplantation NNP cord-005453-4057qib7 8147 4 Program Program NNP cord-005453-4057qib7 8147 5 with with IN cord-005453-4057qib7 8147 6 MACS MACS NNPS cord-005453-4057qib7 8147 7 was be VBD cord-005453-4057qib7 8147 8 implemented implement VBN cord-005453-4057qib7 8147 9 in in IN cord-005453-4057qib7 8147 10 Peru Peru NNP cord-005453-4057qib7 8147 11 in in IN cord-005453-4057qib7 8147 12 2016 2016 CD cord-005453-4057qib7 8147 13 to to TO cord-005453-4057qib7 8147 14 reduce reduce VB cord-005453-4057qib7 8147 15 the the DT cord-005453-4057qib7 8147 16 risk risk NN cord-005453-4057qib7 8147 17 of of IN cord-005453-4057qib7 8147 18 Graft graft NN cord-005453-4057qib7 8147 19 - - HYPH cord-005453-4057qib7 8147 20 versus versus IN cord-005453-4057qib7 8147 21 - - HYPH cord-005453-4057qib7 8147 22 Host host NN cord-005453-4057qib7 8147 23 Disease Disease NNP cord-005453-4057qib7 8147 24 ( ( -LRB- cord-005453-4057qib7 8147 25 GvHD GvHD NNP cord-005453-4057qib7 8147 26 ) ) -RRB- cord-005453-4057qib7 8147 27 , , , cord-005453-4057qib7 8147 28 support support VB cord-005453-4057qib7 8147 29 the the DT cord-005453-4057qib7 8147 30 immune immune JJ cord-005453-4057qib7 8147 31 system system NN cord-005453-4057qib7 8147 32 reconstitution reconstitution NN cord-005453-4057qib7 8147 33 and and CC cord-005453-4057qib7 8147 34 to to TO cord-005453-4057qib7 8147 35 expand expand VB cord-005453-4057qib7 8147 36 pool pool NN cord-005453-4057qib7 8147 37 of of IN cord-005453-4057qib7 8147 38 donors donor NNS cord-005453-4057qib7 8147 39 . . . cord-005453-4057qib7 8148 1 It -PRON- PRP cord-005453-4057qib7 8148 2 allows allow VBZ cord-005453-4057qib7 8148 3 patients patient NNS cord-005453-4057qib7 8148 4 to to TO cord-005453-4057qib7 8148 5 access access VB cord-005453-4057qib7 8148 6 a a DT cord-005453-4057qib7 8148 7 treatment treatment NN cord-005453-4057qib7 8148 8 that that WDT cord-005453-4057qib7 8148 9 is be VBZ cord-005453-4057qib7 8148 10 efficient efficient JJ cord-005453-4057qib7 8148 11 and and CC cord-005453-4057qib7 8148 12 safe safe JJ cord-005453-4057qib7 8148 13 , , , cord-005453-4057qib7 8148 14 as as IN cord-005453-4057qib7 8148 15 shown show VBN cord-005453-4057qib7 8148 16 in in IN cord-005453-4057qib7 8148 17 the the DT cord-005453-4057qib7 8148 18 depletion depletion NN cord-005453-4057qib7 8148 19 of of IN cord-005453-4057qib7 8148 20 positive positive JJ cord-005453-4057qib7 8148 21 TCRα TCRα NNS cord-005453-4057qib7 8148 22 / / SYM cord-005453-4057qib7 8148 23 β+ β+ NNP cord-005453-4057qib7 8148 24 and and CC cord-005453-4057qib7 8148 25 B b NN cord-005453-4057qib7 8148 26 cells cell NNS cord-005453-4057qib7 8148 27 procedures procedure NNS cord-005453-4057qib7 8148 28 for for IN cord-005453-4057qib7 8148 29 allo allo NN cord-005453-4057qib7 8148 30 - - HYPH cord-005453-4057qib7 8148 31 HSCT HSCT NNP cord-005453-4057qib7 8148 32 . . . cord-005453-4057qib7 8149 1 Methods method NNS cord-005453-4057qib7 8149 2 : : : cord-005453-4057qib7 8150 1 The the DT cord-005453-4057qib7 8150 2 mobilized mobilize VBN cord-005453-4057qib7 8150 3 leukapheresis leukapheresis NN cord-005453-4057qib7 8150 4 products product NNS cord-005453-4057qib7 8150 5 ( ( -LRB- cord-005453-4057qib7 8150 6 n=19 n=19 NNP cord-005453-4057qib7 8150 7 ) ) -RRB- cord-005453-4057qib7 8150 8 of of IN cord-005453-4057qib7 8150 9 haploidentical haploidentical JJ cord-005453-4057qib7 8150 10 healthy healthy JJ cord-005453-4057qib7 8150 11 donor donor NN cord-005453-4057qib7 8150 12 was be VBD cord-005453-4057qib7 8150 13 washed wash VBN cord-005453-4057qib7 8150 14 to to TO cord-005453-4057qib7 8150 15 remove remove VB cord-005453-4057qib7 8150 16 platelets platelet NNS cord-005453-4057qib7 8150 17 and and CC cord-005453-4057qib7 8150 18 preparations preparation NNS cord-005453-4057qib7 8150 19 were be VBD cord-005453-4057qib7 8150 20 performed perform VBN cord-005453-4057qib7 8150 21 according accord VBG cord-005453-4057qib7 8150 22 to to IN cord-005453-4057qib7 8150 23 Miltenyi Miltenyi NNP cord-005453-4057qib7 8150 24 's 's POS cord-005453-4057qib7 8150 25 CliniMACS CliniMACS NNP cord-005453-4057qib7 8150 26 ® ® NNP cord-005453-4057qib7 8150 27 manual manual NN cord-005453-4057qib7 8150 28 for for IN cord-005453-4057qib7 8150 29 TCRα TCRα NNS cord-005453-4057qib7 8150 30 / / SYM cord-005453-4057qib7 8150 31 β+ β+ NNP cord-005453-4057qib7 8150 32 and and CC cord-005453-4057qib7 8150 33 CD19 CD19 NNP cord-005453-4057qib7 8150 34 + + CC cord-005453-4057qib7 8150 35 cell cell NN cord-005453-4057qib7 8150 36 depletion depletion NN cord-005453-4057qib7 8150 37 . . . cord-005453-4057qib7 8151 1 Analysis analysis NN cord-005453-4057qib7 8151 2 of of IN cord-005453-4057qib7 8151 3 the the DT cord-005453-4057qib7 8151 4 initial initial JJ cord-005453-4057qib7 8151 5 leukapheresis leukapheresis NN cord-005453-4057qib7 8151 6 product product NN cord-005453-4057qib7 8151 7 and and CC cord-005453-4057qib7 8151 8 TCRα TCRα NNPS cord-005453-4057qib7 8151 9 / / SYM cord-005453-4057qib7 8151 10 β β NN cord-005453-4057qib7 8151 11 + + CC cord-005453-4057qib7 8151 12 and and CC cord-005453-4057qib7 8151 13 CD19 CD19 NNP cord-005453-4057qib7 8151 14 + + CC cord-005453-4057qib7 8151 15 depleted deplete VBN cord-005453-4057qib7 8151 16 graft graft NN cord-005453-4057qib7 8151 17 ( ( -LRB- cord-005453-4057qib7 8151 18 target target NN cord-005453-4057qib7 8151 19 and and CC cord-005453-4057qib7 8151 20 non non JJ cord-005453-4057qib7 8151 21 - - JJ cord-005453-4057qib7 8151 22 target target JJ cord-005453-4057qib7 8151 23 product product NN cord-005453-4057qib7 8151 24 ) ) -RRB- cord-005453-4057qib7 8151 25 was be VBD cord-005453-4057qib7 8151 26 performed perform VBN cord-005453-4057qib7 8151 27 using use VBG cord-005453-4057qib7 8151 28 flow flow NN cord-005453-4057qib7 8151 29 cytometer cytometer NN cord-005453-4057qib7 8151 30 . . . cord-005453-4057qib7 8152 1 Cells cell NNS cord-005453-4057qib7 8152 2 were be VBD cord-005453-4057qib7 8152 3 analyzed analyze VBN cord-005453-4057qib7 8152 4 for for IN cord-005453-4057qib7 8152 5 CD3 CD3 NNP cord-005453-4057qib7 8152 6 + + CC cord-005453-4057qib7 8152 7 , , , cord-005453-4057qib7 8152 8 CD45 CD45 NNP cord-005453-4057qib7 8152 9 + + CC cord-005453-4057qib7 8152 10 , , . cord-005453-4057qib7 8153 1 7-AAD 7-aad CD cord-005453-4057qib7 8153 2 , , , cord-005453-4057qib7 8153 3 CD20 CD20 NNP cord-005453-4057qib7 8153 4 + + CC cord-005453-4057qib7 8153 5 , , , cord-005453-4057qib7 8153 6 TCRα tcrα NN cord-005453-4057qib7 8153 7 / / SYM cord-005453-4057qib7 8153 8 β+ β+ XX cord-005453-4057qib7 8154 1 , , , cord-005453-4057qib7 8154 2 TCRγ TCRγ NNP cord-005453-4057qib7 8154 3 / / SYM cord-005453-4057qib7 8154 4 δ δ NN cord-005453-4057qib7 8155 1 + + UH cord-005453-4057qib7 8155 2 , , , cord-005453-4057qib7 8155 3 CD34 CD34 NNP cord-005453-4057qib7 8155 4 + + CC cord-005453-4057qib7 8155 5 and and CC cord-005453-4057qib7 8155 6 CD133 CD133 NNP cord-005453-4057qib7 8156 1 + + CC cord-005453-4057qib7 8156 2 with with IN cord-005453-4057qib7 8156 3 fluorochrome fluorochrome RB cord-005453-4057qib7 8156 4 - - HYPH cord-005453-4057qib7 8156 5 labeled label VBN cord-005453-4057qib7 8156 6 antibodies antibody NNS cord-005453-4057qib7 8156 7 from from IN cord-005453-4057qib7 8156 8 Miltenyi Miltenyi NNP cord-005453-4057qib7 8156 9 Biotec Biotec NNP cord-005453-4057qib7 8156 10 using use VBG cord-005453-4057qib7 8156 11 a a DT cord-005453-4057qib7 8156 12 NovoCyte NovoCyte NNP cord-005453-4057qib7 8156 13 Cytometer Cytometer NNP cord-005453-4057qib7 8156 14 . . . cord-005453-4057qib7 8157 1 The the DT cord-005453-4057qib7 8157 2 results result NNS cord-005453-4057qib7 8157 3 obtained obtain VBN cord-005453-4057qib7 8157 4 with with IN cord-005453-4057qib7 8157 5 the the DT cord-005453-4057qib7 8157 6 ex ex FW cord-005453-4057qib7 8157 7 vivo vivo NN cord-005453-4057qib7 8157 8 T t NN cord-005453-4057qib7 8157 9 - - HYPH cord-005453-4057qib7 8157 10 cell cell NN cord-005453-4057qib7 8157 11 depleted deplete VBN cord-005453-4057qib7 8157 12 allo allo NN cord-005453-4057qib7 8157 13 - - HYPH cord-005453-4057qib7 8157 14 HSCT HSCT NNP cord-005453-4057qib7 8157 15 procedures procedure NNS cord-005453-4057qib7 8157 16 show show VBP cord-005453-4057qib7 8157 17 an an DT cord-005453-4057qib7 8157 18 overall overall JJ cord-005453-4057qib7 8157 19 survival survival NN cord-005453-4057qib7 8157 20 ( ( -LRB- cord-005453-4057qib7 8157 21 OS OS NNP cord-005453-4057qib7 8157 22 ) ) -RRB- cord-005453-4057qib7 8157 23 over over IN cord-005453-4057qib7 8157 24 70 70 CD cord-005453-4057qib7 8157 25 % % NN cord-005453-4057qib7 8157 26 with with IN cord-005453-4057qib7 8157 27 an an DT cord-005453-4057qib7 8157 28 IC95 IC95 NNP cord-005453-4057qib7 8157 29 % % NN cord-005453-4057qib7 8157 30 at at IN cord-005453-4057qib7 8157 31 the the DT cord-005453-4057qib7 8157 32 end end NN cord-005453-4057qib7 8157 33 of of IN cord-005453-4057qib7 8157 34 the the DT cord-005453-4057qib7 8157 35 first first JJ cord-005453-4057qib7 8157 36 year year NN cord-005453-4057qib7 8157 37 with with IN cord-005453-4057qib7 8157 38 low low JJ cord-005453-4057qib7 8157 39 incidence incidence NN cord-005453-4057qib7 8157 40 of of IN cord-005453-4057qib7 8157 41 GvHD GvHD NNP cord-005453-4057qib7 8157 42 . . . cord-005453-4057qib7 8158 1 MACS mac NNS cord-005453-4057qib7 8158 2 of of IN cord-005453-4057qib7 8158 3 TcRα/ TcRα/ NNP cord-005453-4057qib7 8159 1 β+ β+ NNP cord-005453-4057qib7 8159 2 and and CC cord-005453-4057qib7 8160 1 CD19 CD19 NNP cord-005453-4057qib7 8160 2 + + CC cord-005453-4057qib7 8160 3 cells cell NNS cord-005453-4057qib7 8160 4 are be VBP cord-005453-4057qib7 8160 5 effective effective JJ cord-005453-4057qib7 8160 6 ( ( -LRB- cord-005453-4057qib7 8160 7 LogP LogP NNP cord-005453-4057qib7 8160 8 3.9 3.9 CD cord-005453-4057qib7 8160 9 and and CC cord-005453-4057qib7 8160 10 LogP LogP NNP cord-005453-4057qib7 8160 11 3.3 3.3 CD cord-005453-4057qib7 8160 12 , , , cord-005453-4057qib7 8160 13 respectively respectively RB cord-005453-4057qib7 8160 14 ) ) -RRB- cord-005453-4057qib7 8160 15 obtaining obtain VBG cord-005453-4057qib7 8160 16 minimum minimum JJ cord-005453-4057qib7 8160 17 levels level NNS cord-005453-4057qib7 8160 18 of of IN cord-005453-4057qib7 8160 19 depleted depleted JJ cord-005453-4057qib7 8160 20 lymphocytes lymphocyte NNS cord-005453-4057qib7 8160 21 within within IN cord-005453-4057qib7 8160 22 clinical clinical JJ cord-005453-4057qib7 8160 23 established establish VBN cord-005453-4057qib7 8160 24 parameters parameter NNS cord-005453-4057qib7 8160 25 for for IN cord-005453-4057qib7 8160 26 diverse diverse JJ cord-005453-4057qib7 8160 27 pathologies pathology NNS cord-005453-4057qib7 8160 28 . . . cord-005453-4057qib7 8161 1 In in IN cord-005453-4057qib7 8161 2 addition addition NN cord-005453-4057qib7 8161 3 , , , cord-005453-4057qib7 8161 4 TcRα TcRα NNP cord-005453-4057qib7 8161 5 / / SYM cord-005453-4057qib7 8161 6 β+ β+ NNP cord-005453-4057qib7 8161 7 and and CC cord-005453-4057qib7 8161 8 CD19 CD19 NNP cord-005453-4057qib7 8161 9 + + CC cord-005453-4057qib7 8161 10 cell cell NN cord-005453-4057qib7 8161 11 depletion depletion NN cord-005453-4057qib7 8161 12 does do VBZ cord-005453-4057qib7 8161 13 not not RB cord-005453-4057qib7 8161 14 significantly significantly RB cord-005453-4057qib7 8161 15 affect affect VB cord-005453-4057qib7 8161 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 8161 17 stem stem NN cord-005453-4057qib7 8161 18 cell cell NN cord-005453-4057qib7 8161 19 populations population NNS cord-005453-4057qib7 8161 20 such such JJ cord-005453-4057qib7 8161 21 as as IN cord-005453-4057qib7 8161 22 CD34 CD34 NNP cord-005453-4057qib7 8161 23 + + CC cord-005453-4057qib7 8162 1 and and CC cord-005453-4057qib7 8162 2 CD133 CD133 NNP cord-005453-4057qib7 8163 1 + + CC cord-005453-4057qib7 8163 2 cells cell NNS cord-005453-4057qib7 8163 3 or or CC cord-005453-4057qib7 8163 4 TcRγ TcRγ NNP cord-005453-4057qib7 8163 5 / / SYM cord-005453-4057qib7 8163 6 δ+ δ+ JJ cord-005453-4057qib7 8163 7 cell cell NN cord-005453-4057qib7 8163 8 population population NN cord-005453-4057qib7 8163 9 . . . cord-005453-4057qib7 8164 1 CD34 CD34 NNP cord-005453-4057qib7 8164 2 + + CC cord-005453-4057qib7 8164 3 and and CC cord-005453-4057qib7 8164 4 TCR TCR NNP cord-005453-4057qib7 8164 5 γ/ γ/ NNP cord-005453-4057qib7 8165 1 δ δ NN cord-005453-4057qib7 8165 2 cells cell NNS cord-005453-4057qib7 8165 3 are be VBP cord-005453-4057qib7 8165 4 highly highly RB cord-005453-4057qib7 8165 5 recovered recover VBN cord-005453-4057qib7 8165 6 ( ( -LRB- cord-005453-4057qib7 8165 7 93.15 93.15 CD cord-005453-4057qib7 8165 8 % % NN cord-005453-4057qib7 8165 9 and and CC cord-005453-4057qib7 8165 10 88.76 88.76 CD cord-005453-4057qib7 8165 11 , , , cord-005453-4057qib7 8165 12 respectively respectively RB cord-005453-4057qib7 8165 13 ) ) -RRB- cord-005453-4057qib7 8165 14 , , , cord-005453-4057qib7 8165 15 which which WDT cord-005453-4057qib7 8165 16 contributes contribute VBZ cord-005453-4057qib7 8165 17 with with IN cord-005453-4057qib7 8165 18 a a DT cord-005453-4057qib7 8165 19 better well JJR cord-005453-4057qib7 8165 20 engraftment engraftment NN cord-005453-4057qib7 8165 21 after after IN cord-005453-4057qib7 8165 22 allo allo NN cord-005453-4057qib7 8165 23 - - HYPH cord-005453-4057qib7 8165 24 HSCT HSCT NNP cord-005453-4057qib7 8165 25 . . . cord-005453-4057qib7 8166 1 Conclusions conclusion NNS cord-005453-4057qib7 8166 2 : : : cord-005453-4057qib7 8167 1 Peruvian peruvian JJ cord-005453-4057qib7 8167 2 results result NNS cord-005453-4057qib7 8167 3 oscillated oscillate VBD cord-005453-4057qib7 8167 4 within within IN cord-005453-4057qib7 8167 5 European european JJ cord-005453-4057qib7 8167 6 ranges range NNS cord-005453-4057qib7 8167 7 with with IN cord-005453-4057qib7 8167 8 an an DT cord-005453-4057qib7 8167 9 OS os NN cord-005453-4057qib7 8167 10 over over IN cord-005453-4057qib7 8167 11 70 70 CD cord-005453-4057qib7 8167 12 % % NN cord-005453-4057qib7 8167 13 . . . cord-005453-4057qib7 8168 1 Our -PRON- PRP$ cord-005453-4057qib7 8168 2 data data NN cord-005453-4057qib7 8168 3 suggests suggest VBZ cord-005453-4057qib7 8168 4 that that IN cord-005453-4057qib7 8168 5 the the DT cord-005453-4057qib7 8168 6 MACS MACS NNPS cord-005453-4057qib7 8168 7 method method NN cord-005453-4057qib7 8168 8 is be VBZ cord-005453-4057qib7 8168 9 an an DT cord-005453-4057qib7 8168 10 efficient efficient JJ cord-005453-4057qib7 8168 11 , , , cord-005453-4057qib7 8168 12 effective effective JJ cord-005453-4057qib7 8168 13 and and CC cord-005453-4057qib7 8168 14 safe safe JJ cord-005453-4057qib7 8168 15 strategy strategy NN cord-005453-4057qib7 8168 16 for for IN cord-005453-4057qib7 8168 17 haploidentical haploidentical JJ cord-005453-4057qib7 8168 18 HSCT HSCT NNP cord-005453-4057qib7 8168 19 which which WDT cord-005453-4057qib7 8168 20 has have VBZ cord-005453-4057qib7 8168 21 a a DT cord-005453-4057qib7 8168 22 remarkable remarkable JJ cord-005453-4057qib7 8168 23 cost cost NN cord-005453-4057qib7 8168 24 - - HYPH cord-005453-4057qib7 8168 25 benefit benefit NN cord-005453-4057qib7 8168 26 ratio ratio NN cord-005453-4057qib7 8168 27 and and CC cord-005453-4057qib7 8168 28 makes make VBZ cord-005453-4057qib7 8168 29 it -PRON- PRP cord-005453-4057qib7 8168 30 viable viable JJ cord-005453-4057qib7 8168 31 in in IN cord-005453-4057qib7 8168 32 countries country NNS cord-005453-4057qib7 8168 33 of of IN cord-005453-4057qib7 8168 34 the the DT cord-005453-4057qib7 8168 35 Latin latin JJ cord-005453-4057qib7 8168 36 American american JJ cord-005453-4057qib7 8168 37 region region NN cord-005453-4057qib7 8168 38 with with IN cord-005453-4057qib7 8168 39 Peruvian peruvian JJ cord-005453-4057qib7 8168 40 socio socio JJ cord-005453-4057qib7 8168 41 - - HYPH cord-005453-4057qib7 8168 42 economic economic JJ cord-005453-4057qib7 8168 43 characteristics characteristic NNS cord-005453-4057qib7 8168 44 . . . cord-005453-4057qib7 8169 1 Evaluation evaluation NN cord-005453-4057qib7 8169 2 of of IN cord-005453-4057qib7 8169 3 genoresistance genoresistance NNP cord-005453-4057qib7 8169 4 for for IN cord-005453-4057qib7 8169 5 viral viral JJ cord-005453-4057qib7 8169 6 reactivation reactivation NN cord-005453-4057qib7 8169 7 treatment treatment NN cord-005453-4057qib7 8169 8 has have VBZ cord-005453-4057qib7 8169 9 been be VBN cord-005453-4057qib7 8169 10 implemented implement VBN cord-005453-4057qib7 8169 11 as as IN cord-005453-4057qib7 8169 12 a a DT cord-005453-4057qib7 8169 13 strategy strategy NN cord-005453-4057qib7 8169 14 to to TO cord-005453-4057qib7 8169 15 improve improve VB cord-005453-4057qib7 8169 16 OS OS NNP cord-005453-4057qib7 8169 17 . . . cord-005453-4057qib7 8170 1 Better well JJR cord-005453-4057qib7 8170 2 results result NNS cord-005453-4057qib7 8170 3 are be VBP cord-005453-4057qib7 8170 4 achieved achieve VBN cord-005453-4057qib7 8170 5 in in IN cord-005453-4057qib7 8170 6 patients patient NNS cord-005453-4057qib7 8170 7 after after IN cord-005453-4057qib7 8170 8 allo allo NN cord-005453-4057qib7 8170 9 - - HYPH cord-005453-4057qib7 8170 10 HSCT HSCT NNP cord-005453-4057qib7 8170 11 with with IN cord-005453-4057qib7 8170 12 the the DT cord-005453-4057qib7 8170 13 validation validation NN cord-005453-4057qib7 8170 14 of of IN cord-005453-4057qib7 8170 15 these these DT cord-005453-4057qib7 8170 16 tests test NNS cord-005453-4057qib7 8170 17 in in IN cord-005453-4057qib7 8170 18 Peru Peru NNP cord-005453-4057qib7 8170 19 . . . cord-005453-4057qib7 8171 1 Preliminary preliminary JJ cord-005453-4057qib7 8171 2 pharmacoeconomic pharmacoeconomic JJ cord-005453-4057qib7 8171 3 evaluations evaluation NNS cord-005453-4057qib7 8171 4 allow allow VBP cord-005453-4057qib7 8171 5 us -PRON- PRP cord-005453-4057qib7 8171 6 to to TO cord-005453-4057qib7 8171 7 establish establish VB cord-005453-4057qib7 8171 8 Magnetic Magnetic NNP cord-005453-4057qib7 8171 9 Activated activate VBN cord-005453-4057qib7 8171 10 Cell cell NN cord-005453-4057qib7 8171 11 Sorting sorting NN cord-005453-4057qib7 8171 12 ( ( -LRB- cord-005453-4057qib7 8171 13 MACS MACS NNPS cord-005453-4057qib7 8171 14 ) ) -RRB- cord-005453-4057qib7 8171 15 as as IN cord-005453-4057qib7 8171 16 a a DT cord-005453-4057qib7 8171 17 promissory promissory JJ cord-005453-4057qib7 8171 18 strategy strategy NN cord-005453-4057qib7 8171 19 compared compare VBN cord-005453-4057qib7 8171 20 to to IN cord-005453-4057qib7 8171 21 other other JJ cord-005453-4057qib7 8171 22 alternatives alternative NNS cord-005453-4057qib7 8171 23 for for IN cord-005453-4057qib7 8171 24 haploidentical haploidentical JJ cord-005453-4057qib7 8171 25 HSCT HSCT NNP cord-005453-4057qib7 8171 26 . . . cord-005453-4057qib7 8172 1 It -PRON- PRP cord-005453-4057qib7 8172 2 is be VBZ cord-005453-4057qib7 8172 3 necessary necessary JJ cord-005453-4057qib7 8172 4 to to TO cord-005453-4057qib7 8172 5 increase increase VB cord-005453-4057qib7 8172 6 the the DT cord-005453-4057qib7 8172 7 number number NN cord-005453-4057qib7 8172 8 of of IN cord-005453-4057qib7 8172 9 procedures procedure NNS cord-005453-4057qib7 8172 10 in in IN cord-005453-4057qib7 8172 11 order order NN cord-005453-4057qib7 8172 12 to to TO cord-005453-4057qib7 8172 13 confirm confirm VB cord-005453-4057qib7 8172 14 efficacy efficacy NN cord-005453-4057qib7 8172 15 and and CC cord-005453-4057qib7 8172 16 safety safety NN cord-005453-4057qib7 8172 17 of of IN cord-005453-4057qib7 8172 18 MACS MACS NNPS cord-005453-4057qib7 8172 19 in in IN cord-005453-4057qib7 8172 20 a a DT cord-005453-4057qib7 8172 21 larger large JJR cord-005453-4057qib7 8172 22 population population NN cord-005453-4057qib7 8172 23 . . . cord-005453-4057qib7 8173 1 Disclosure disclosure NN cord-005453-4057qib7 8173 2 : : : cord-005453-4057qib7 8174 1 All all DT cord-005453-4057qib7 8174 2 authors author NNS cord-005453-4057qib7 8174 3 have have VBP cord-005453-4057qib7 8174 4 no no DT cord-005453-4057qib7 8174 5 conflicts conflict NNS cord-005453-4057qib7 8174 6 of of IN cord-005453-4057qib7 8174 7 interest interest NN cord-005453-4057qib7 8174 8 . . . cord-005453-4057qib7 8175 1 Abstract Abstract NNP cord-005453-4057qib7 8175 2 already already RB cord-005453-4057qib7 8175 3 published publish VBN cord-005453-4057qib7 8175 4 . . . cord-005453-4057qib7 8176 1 Micro micro JJ cord-005453-4057qib7 8176 2 - - HYPH cord-005453-4057qib7 8176 3 costing costing NN cord-005453-4057qib7 8176 4 study study NN cord-005453-4057qib7 8176 5 of of IN cord-005453-4057qib7 8176 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 8176 7 stem stem NN cord-005453-4057qib7 8176 8 cell cell NN cord-005453-4057qib7 8176 9 transplantation transplantation NN cord-005453-4057qib7 8176 10 in in IN cord-005453-4057qib7 8176 11 two two CD cord-005453-4057qib7 8176 12 hospital hospital NN cord-005453-4057qib7 8176 13 institutions institution NNS cord-005453-4057qib7 8176 14 from from IN cord-005453-4057qib7 8176 15 southern southern JJ cord-005453-4057qib7 8176 16 of of IN cord-005453-4057qib7 8176 17 Brazil Brazil NNP cord-005453-4057qib7 8176 18 Background Background NNP cord-005453-4057qib7 8176 19 : : : cord-005453-4057qib7 8176 20 Hematopoietic hematopoietic JJ cord-005453-4057qib7 8176 21 stem stem NN cord-005453-4057qib7 8176 22 cell cell NN cord-005453-4057qib7 8176 23 transplantation transplantation NN cord-005453-4057qib7 8176 24 ( ( -LRB- cord-005453-4057qib7 8176 25 HSCT HSCT NNP cord-005453-4057qib7 8176 26 ) ) -RRB- cord-005453-4057qib7 8176 27 is be VBZ cord-005453-4057qib7 8176 28 a a DT cord-005453-4057qib7 8176 29 potentially potentially RB cord-005453-4057qib7 8176 30 curative curative JJ cord-005453-4057qib7 8176 31 treatment treatment NN cord-005453-4057qib7 8176 32 indicated indicate VBN cord-005453-4057qib7 8176 33 for for IN cord-005453-4057qib7 8176 34 patients patient NNS cord-005453-4057qib7 8176 35 with with IN cord-005453-4057qib7 8176 36 onco onco JJ cord-005453-4057qib7 8176 37 - - HYPH cord-005453-4057qib7 8176 38 hematological hematological JJ cord-005453-4057qib7 8176 39 , , , cord-005453-4057qib7 8176 40 hereditary hereditary JJ cord-005453-4057qib7 8176 41 and and CC cord-005453-4057qib7 8176 42 immunological immunological JJ cord-005453-4057qib7 8176 43 diseases disease NNS cord-005453-4057qib7 8176 44 . . . cord-005453-4057qib7 8177 1 Considering consider VBG cord-005453-4057qib7 8177 2 the the DT cord-005453-4057qib7 8177 3 increase increase NN cord-005453-4057qib7 8177 4 of of IN cord-005453-4057qib7 8177 5 patients patient NNS cord-005453-4057qib7 8177 6 indicated indicate VBN cord-005453-4057qib7 8177 7 to to IN cord-005453-4057qib7 8177 8 the the DT cord-005453-4057qib7 8177 9 HSCT HSCT NNP cord-005453-4057qib7 8177 10 and and CC cord-005453-4057qib7 8177 11 the the DT cord-005453-4057qib7 8177 12 lack lack NN cord-005453-4057qib7 8177 13 of of IN cord-005453-4057qib7 8177 14 knowledge knowledge NN cord-005453-4057qib7 8177 15 about about IN cord-005453-4057qib7 8177 16 the the DT cord-005453-4057qib7 8177 17 costs cost NNS cord-005453-4057qib7 8177 18 resulting result VBG cord-005453-4057qib7 8177 19 from from IN cord-005453-4057qib7 8177 20 this this DT cord-005453-4057qib7 8177 21 treatment treatment NN cord-005453-4057qib7 8177 22 , , , cord-005453-4057qib7 8177 23 is be VBZ cord-005453-4057qib7 8177 24 important important JJ cord-005453-4057qib7 8177 25 to to TO cord-005453-4057qib7 8177 26 identify identify VB cord-005453-4057qib7 8177 27 and and CC cord-005453-4057qib7 8177 28 detail detail VB cord-005453-4057qib7 8177 29 the the DT cord-005453-4057qib7 8177 30 resources resource NNS cord-005453-4057qib7 8177 31 consumed consume VBN cord-005453-4057qib7 8177 32 in in IN cord-005453-4057qib7 8177 33 each each DT cord-005453-4057qib7 8177 34 phase phase NN cord-005453-4057qib7 8177 35 of of IN cord-005453-4057qib7 8177 36 HSCT HSCT NNP cord-005453-4057qib7 8177 37 and and CC cord-005453-4057qib7 8177 38 provide provide VB cord-005453-4057qib7 8177 39 knowledge knowledge NN cord-005453-4057qib7 8177 40 to to IN cord-005453-4057qib7 8177 41 the the DT cord-005453-4057qib7 8177 42 public public JJ cord-005453-4057qib7 8177 43 health health NN cord-005453-4057qib7 8177 44 brazilian brazilian NN cord-005453-4057qib7 8177 45 system system NN cord-005453-4057qib7 8177 46 . . . cord-005453-4057qib7 8178 1 We -PRON- PRP cord-005453-4057qib7 8178 2 aimed aim VBD cord-005453-4057qib7 8178 3 measure measure VB cord-005453-4057qib7 8178 4 the the DT cord-005453-4057qib7 8178 5 total total JJ cord-005453-4057qib7 8178 6 cost cost NN cord-005453-4057qib7 8178 7 of of IN cord-005453-4057qib7 8178 8 related related JJ cord-005453-4057qib7 8178 9 HSCT HSCT NNP cord-005453-4057qib7 8178 10 , , , cord-005453-4057qib7 8178 11 based base VBN cord-005453-4057qib7 8178 12 on on IN cord-005453-4057qib7 8178 13 micro micro JJ cord-005453-4057qib7 8178 14 - - JJ cord-005453-4057qib7 8178 15 costing costing JJ cord-005453-4057qib7 8178 16 study study NN cord-005453-4057qib7 8178 17 of of IN cord-005453-4057qib7 8178 18 patients patient NNS cord-005453-4057qib7 8178 19 assisted assist VBN cord-005453-4057qib7 8178 20 in in IN cord-005453-4057qib7 8178 21 two two CD cord-005453-4057qib7 8178 22 hospitals hospital NNS cord-005453-4057qib7 8178 23 in in IN cord-005453-4057qib7 8178 24 the the DT cord-005453-4057qib7 8178 25 South South NNP cord-005453-4057qib7 8178 26 region region NN cord-005453-4057qib7 8178 27 of of IN cord-005453-4057qib7 8178 28 Brazil Brazil NNP cord-005453-4057qib7 8178 29 . . . cord-005453-4057qib7 8179 1 Methods method NNS cord-005453-4057qib7 8179 2 : : : cord-005453-4057qib7 8179 3 HSCT HSCT NNP cord-005453-4057qib7 8179 4 costs cost NNS cord-005453-4057qib7 8179 5 were be VBD cord-005453-4057qib7 8179 6 estimated estimate VBN cord-005453-4057qib7 8179 7 using use VBG cord-005453-4057qib7 8179 8 the the DT cord-005453-4057qib7 8179 9 timedriven timedriven NNP cord-005453-4057qib7 8179 10 activity activity NN cord-005453-4057qib7 8179 11 based base VBN cord-005453-4057qib7 8179 12 costing costing NN cord-005453-4057qib7 8179 13 method method NN cord-005453-4057qib7 8179 14 ( ( -LRB- cord-005453-4057qib7 8179 15 TDABC TDABC NNP cord-005453-4057qib7 8179 16 ) ) -RRB- cord-005453-4057qib7 8179 17 , , , cord-005453-4057qib7 8179 18 which which WDT cord-005453-4057qib7 8179 19 measured measure VBD cord-005453-4057qib7 8179 20 cost cost NN cord-005453-4057qib7 8179 21 of of IN cord-005453-4057qib7 8179 22 services service NNS cord-005453-4057qib7 8179 23 / / SYM cord-005453-4057qib7 8179 24 products product NNS cord-005453-4057qib7 8179 25 based base VBN cord-005453-4057qib7 8179 26 on on IN cord-005453-4057qib7 8179 27 actual actual JJ cord-005453-4057qib7 8179 28 consumption consumption NN cord-005453-4057qib7 8179 29 of of IN cord-005453-4057qib7 8179 30 resources resource NNS cord-005453-4057qib7 8179 31 . . . cord-005453-4057qib7 8180 1 We -PRON- PRP cord-005453-4057qib7 8180 2 collected collect VBD cord-005453-4057qib7 8180 3 data datum NNS cord-005453-4057qib7 8180 4 from from IN cord-005453-4057qib7 8180 5 medical medical JJ cord-005453-4057qib7 8180 6 records record NNS cord-005453-4057qib7 8180 7 of of IN cord-005453-4057qib7 8180 8 12 12 CD cord-005453-4057qib7 8180 9 patients patient NNS cord-005453-4057qib7 8180 10 submitted submit VBN cord-005453-4057qib7 8180 11 to to IN cord-005453-4057qib7 8180 12 allogeneic allogeneic VB cord-005453-4057qib7 8180 13 HSCT HSCT NNP cord-005453-4057qib7 8180 14 in in IN cord-005453-4057qib7 8180 15 2017 2017 CD cord-005453-4057qib7 8180 16 from from IN cord-005453-4057qib7 8180 17 public public JJ cord-005453-4057qib7 8180 18 and and CC cord-005453-4057qib7 8180 19 private private JJ cord-005453-4057qib7 8180 20 ( ( -LRB- cord-005453-4057qib7 8180 21 philanthropic philanthropic JJ cord-005453-4057qib7 8180 22 ) ) -RRB- cord-005453-4057qib7 8180 23 hospitals hospital NNS cord-005453-4057qib7 8180 24 . . . cord-005453-4057qib7 8181 1 We -PRON- PRP cord-005453-4057qib7 8181 2 interviewed interview VBD cord-005453-4057qib7 8181 3 professionals professional NNS cord-005453-4057qib7 8181 4 involved involve VBN cord-005453-4057qib7 8181 5 in in IN cord-005453-4057qib7 8181 6 the the DT cord-005453-4057qib7 8181 7 TCTH TCTH NNP cord-005453-4057qib7 8181 8 activities activity NNS cord-005453-4057qib7 8181 9 , , , cord-005453-4057qib7 8181 10 we -PRON- PRP cord-005453-4057qib7 8181 11 performed perform VBD cord-005453-4057qib7 8181 12 chrono chrono NN cord-005453-4057qib7 8181 13 - - HYPH cord-005453-4057qib7 8181 14 analysis analysis NN cord-005453-4057qib7 8181 15 and and CC cord-005453-4057qib7 8181 16 , , , cord-005453-4057qib7 8181 17 we -PRON- PRP cord-005453-4057qib7 8181 18 consulted consult VBD cord-005453-4057qib7 8181 19 financial financial JJ cord-005453-4057qib7 8181 20 and and CC cord-005453-4057qib7 8181 21 administrative administrative JJ cord-005453-4057qib7 8181 22 systems system NNS cord-005453-4057qib7 8181 23 reports report NNS cord-005453-4057qib7 8181 24 of of IN cord-005453-4057qib7 8181 25 hospitals hospital NNS cord-005453-4057qib7 8181 26 . . . cord-005453-4057qib7 8182 1 In in IN cord-005453-4057qib7 8182 2 order order NN cord-005453-4057qib7 8182 3 to to TO cord-005453-4057qib7 8182 4 compare compare VB cord-005453-4057qib7 8182 5 costs cost NNS cord-005453-4057qib7 8182 6 according accord VBG cord-005453-4057qib7 8182 7 to to IN cord-005453-4057qib7 8182 8 clinical clinical JJ cord-005453-4057qib7 8182 9 complications complication NNS cord-005453-4057qib7 8182 10 observed observe VBN cord-005453-4057qib7 8182 11 in in IN cord-005453-4057qib7 8182 12 patients patient NNS cord-005453-4057qib7 8182 13 , , , cord-005453-4057qib7 8182 14 we -PRON- PRP cord-005453-4057qib7 8182 15 grouped group VBD cord-005453-4057qib7 8182 16 into into IN cord-005453-4057qib7 8182 17 two two CD cord-005453-4057qib7 8182 18 ranges range NNS cord-005453-4057qib7 8182 19 of of IN cord-005453-4057qib7 8182 20 complexity complexity NN cord-005453-4057qib7 8182 21 : : : cord-005453-4057qib7 8182 22 low/ low/ CD cord-005453-4057qib7 8182 23 medium medium NN cord-005453-4057qib7 8182 24 and and CC cord-005453-4057qib7 8182 25 high high JJ cord-005453-4057qib7 8182 26 . . . cord-005453-4057qib7 8183 1 The the DT cord-005453-4057qib7 8183 2 study study NN cord-005453-4057qib7 8183 3 was be VBD cord-005453-4057qib7 8183 4 divided divide VBN cord-005453-4057qib7 8183 5 into into IN cord-005453-4057qib7 8183 6 stages stage NNS cord-005453-4057qib7 8183 7 : : : cord-005453-4057qib7 8183 8 HSCT HSCT NNP cord-005453-4057qib7 8183 9 processes process VBZ cord-005453-4057qib7 8183 10 mapping mapping NN cord-005453-4057qib7 8183 11 ; ; : cord-005453-4057qib7 8183 12 costs cost NNS cord-005453-4057qib7 8183 13 measurement measurement NN cord-005453-4057qib7 8183 14 ; ; : cord-005453-4057qib7 8183 15 and and CC cord-005453-4057qib7 8183 16 analysis analysis NN cord-005453-4057qib7 8183 17 of of IN cord-005453-4057qib7 8183 18 results result NNS cord-005453-4057qib7 8183 19 . . . cord-005453-4057qib7 8184 1 Finally finally RB cord-005453-4057qib7 8184 2 , , , cord-005453-4057qib7 8184 3 the the DT cord-005453-4057qib7 8184 4 costs cost NNS cord-005453-4057qib7 8184 5 were be VBD cord-005453-4057qib7 8184 6 compared compare VBN cord-005453-4057qib7 8184 7 : : : cord-005453-4057qib7 8184 8 by by IN cord-005453-4057qib7 8184 9 activity activity NN cord-005453-4057qib7 8184 10 , , , cord-005453-4057qib7 8184 11 by by IN cord-005453-4057qib7 8184 12 resource resource NN cord-005453-4057qib7 8184 13 and and CC cord-005453-4057qib7 8184 14 by by IN cord-005453-4057qib7 8184 15 hospital hospital NN cord-005453-4057qib7 8184 16 . . . cord-005453-4057qib7 8185 1 This this DT cord-005453-4057qib7 8185 2 study study NN cord-005453-4057qib7 8185 3 was be VBD cord-005453-4057qib7 8185 4 financed finance VBN cord-005453-4057qib7 8185 5 by by IN cord-005453-4057qib7 8185 6 PSID PSID NNP cord-005453-4057qib7 8185 7 - - HYPH cord-005453-4057qib7 8185 8 UHS UHS NNP cord-005453-4057qib7 8185 9 , , , cord-005453-4057qib7 8185 10 by by IN cord-005453-4057qib7 8185 11 an an DT cord-005453-4057qib7 8185 12 agreement agreement NN cord-005453-4057qib7 8185 13 signed sign VBN cord-005453-4057qib7 8185 14 between between IN cord-005453-4057qib7 8185 15 Ministry Ministry NNP cord-005453-4057qib7 8185 16 of of IN cord-005453-4057qib7 8185 17 Health Health NNP cord-005453-4057qib7 8185 18 and and CC cord-005453-4057qib7 8185 19 Moinhos Moinhos NNP cord-005453-4057qib7 8185 20 de de NNP cord-005453-4057qib7 8185 21 Vento Vento NNP cord-005453-4057qib7 8185 22 Hospital Hospital NNP cord-005453-4057qib7 8185 23 , , , cord-005453-4057qib7 8185 24 through through IN cord-005453-4057qib7 8185 25 adjustment adjustment NN cord-005453-4057qib7 8185 26 term term NN cord-005453-4057qib7 8185 27 number number NN cord-005453-4057qib7 8185 28 : : : cord-005453-4057qib7 8185 29 04 04 CD cord-005453-4057qib7 8185 30 / / SYM cord-005453-4057qib7 8185 31 2014 2014 CD cord-005453-4057qib7 8185 32 , , , cord-005453-4057qib7 8185 33 and and CC cord-005453-4057qib7 8185 34 approved approve VBN cord-005453-4057qib7 8185 35 by by IN cord-005453-4057qib7 8185 36 Research Research NNP cord-005453-4057qib7 8185 37 Ethics Ethics NNP cord-005453-4057qib7 8185 38 Committees Committees NNPS cord-005453-4057qib7 8185 39 . . . cord-005453-4057qib7 8186 1 Results result NNS cord-005453-4057qib7 8186 2 : : : cord-005453-4057qib7 8187 1 From from IN cord-005453-4057qib7 8187 2 the the DT cord-005453-4057qib7 8187 3 HSCT HSCT NNP cord-005453-4057qib7 8187 4 processes process NNS cord-005453-4057qib7 8187 5 mapping mapping NN cord-005453-4057qib7 8187 6 , , , cord-005453-4057qib7 8187 7 the the DT cord-005453-4057qib7 8187 8 following following JJ cord-005453-4057qib7 8187 9 steps step NNS cord-005453-4057qib7 8187 10 were be VBD cord-005453-4057qib7 8187 11 defined define VBN cord-005453-4057qib7 8187 12 : : : cord-005453-4057qib7 8187 13 ( ( -LRB- cord-005453-4057qib7 8187 14 I i NN cord-005453-4057qib7 8187 15 ) ) -RRB- cord-005453-4057qib7 8187 16 hospitalization hospitalization NN cord-005453-4057qib7 8187 17 ; ; , cord-005453-4057qib7 8187 18 ( ( -LRB- cord-005453-4057qib7 8187 19 II ii NN cord-005453-4057qib7 8187 20 ) ) -RRB- cord-005453-4057qib7 8187 21 conditioning conditioning NN cord-005453-4057qib7 8187 22 ; ; : cord-005453-4057qib7 8187 23 ( ( -LRB- cord-005453-4057qib7 8187 24 III III NNP cord-005453-4057qib7 8187 25 ) ) -RRB- cord-005453-4057qib7 8187 26 transplantation transplantation NN cord-005453-4057qib7 8187 27 ; ; , cord-005453-4057qib7 8187 28 ( ( -LRB- cord-005453-4057qib7 8187 29 IV IV NNP cord-005453-4057qib7 8187 30 ) ) -RRB- cord-005453-4057qib7 8187 31 period period NN cord-005453-4057qib7 8187 32 of of IN cord-005453-4057qib7 8187 33 aplasia aplasia NNP cord-005453-4057qib7 8187 34 ; ; : cord-005453-4057qib7 8187 35 ( ( -LRB- cord-005453-4057qib7 8187 36 V v NN cord-005453-4057qib7 8187 37 ) ) -RRB- cord-005453-4057qib7 8187 38 engraftment engraftment NN cord-005453-4057qib7 8188 1 ; ; : cord-005453-4057qib7 8188 2 ( ( -LRB- cord-005453-4057qib7 8188 3 VI VI NNP cord-005453-4057qib7 8188 4 ) ) -RRB- cord-005453-4057qib7 8188 5 observation observation NN cord-005453-4057qib7 8188 6 ; ; : cord-005453-4057qib7 8188 7 ( ( -LRB- cord-005453-4057qib7 8188 8 VII VII NNP cord-005453-4057qib7 8188 9 ) ) -RRB- cord-005453-4057qib7 8188 10 pre pre JJ cord-005453-4057qib7 8188 11 - - JJ cord-005453-4057qib7 8188 12 and and CC cord-005453-4057qib7 8188 13 medical medical JJ cord-005453-4057qib7 8188 14 discharge discharge NN cord-005453-4057qib7 8188 15 . . . cord-005453-4057qib7 8189 1 Seven seven CD cord-005453-4057qib7 8189 2 patients patient NNS cord-005453-4057qib7 8189 3 were be VBD cord-005453-4057qib7 8189 4 classified classify VBN cord-005453-4057qib7 8189 5 in in IN cord-005453-4057qib7 8189 6 low low JJ cord-005453-4057qib7 8189 7 / / SYM cord-005453-4057qib7 8189 8 medium medium NN cord-005453-4057qib7 8189 9 complexity complexity NN cord-005453-4057qib7 8189 10 level level NN cord-005453-4057qib7 8189 11 , , , cord-005453-4057qib7 8189 12 with with IN cord-005453-4057qib7 8189 13 hospitalization hospitalization NN cord-005453-4057qib7 8189 14 median median JJ cord-005453-4057qib7 8189 15 time time NN cord-005453-4057qib7 8189 16 of of IN cord-005453-4057qib7 8189 17 41 41 CD cord-005453-4057qib7 8189 18 days day NNS cord-005453-4057qib7 8189 19 and and CC cord-005453-4057qib7 8189 20 an an DT cord-005453-4057qib7 8189 21 median median JJ cord-005453-4057qib7 8189 22 cost cost NN cord-005453-4057qib7 8189 23 of of IN cord-005453-4057qib7 8189 24 USD usd NN cord-005453-4057qib7 8189 25 66,278.29 66,278.29 CD cord-005453-4057qib7 8189 26 , , , cord-005453-4057qib7 8189 27 whereas whereas IN cord-005453-4057qib7 8189 28 the the DT cord-005453-4057qib7 8189 29 other other JJ cord-005453-4057qib7 8189 30 five five CD cord-005453-4057qib7 8189 31 patients patient NNS cord-005453-4057qib7 8189 32 , , , cord-005453-4057qib7 8189 33 classified classify VBN cord-005453-4057qib7 8189 34 as as IN cord-005453-4057qib7 8189 35 high high JJ cord-005453-4057qib7 8189 36 complexity complexity NN cord-005453-4057qib7 8189 37 , , , cord-005453-4057qib7 8189 38 presented present VBN cord-005453-4057qib7 8189 39 median median JJ cord-005453-4057qib7 8189 40 time time NN cord-005453-4057qib7 8189 41 of of IN cord-005453-4057qib7 8189 42 101 101 CD cord-005453-4057qib7 8189 43 days day NNS cord-005453-4057qib7 8189 44 and and CC cord-005453-4057qib7 8189 45 median median JJ cord-005453-4057qib7 8189 46 cost cost NN cord-005453-4057qib7 8189 47 of of IN cord-005453-4057qib7 8189 48 USD USD NNP cord-005453-4057qib7 8189 49 300,367.13 300,367.13 CD cord-005453-4057qib7 8189 50 . . . cord-005453-4057qib7 8190 1 The the DT cord-005453-4057qib7 8190 2 HSCT HSCT NNP cord-005453-4057qib7 8190 3 costs cost VBZ cord-005453-4057qib7 8190 4 evaluation evaluation NN cord-005453-4057qib7 8190 5 identified identify VBD cord-005453-4057qib7 8190 6 that that IN cord-005453-4057qib7 8190 7 steps step VBZ cord-005453-4057qib7 8190 8 II II NNP cord-005453-4057qib7 8190 9 and and CC cord-005453-4057qib7 8190 10 IV IV NNP cord-005453-4057qib7 8190 11 presented present VBD cord-005453-4057qib7 8190 12 greatest great JJS cord-005453-4057qib7 8190 13 cost cost NN cord-005453-4057qib7 8190 14 in in IN cord-005453-4057qib7 8190 15 high high JJ cord-005453-4057qib7 8190 16 complexity complexity NN cord-005453-4057qib7 8190 17 patients patient NNS cord-005453-4057qib7 8190 18 . . . cord-005453-4057qib7 8191 1 Lower low JJR cord-005453-4057qib7 8191 2 complexity complexity NN cord-005453-4057qib7 8191 3 patients patient NNS cord-005453-4057qib7 8191 4 presented present VBN cord-005453-4057qib7 8191 5 , , , cord-005453-4057qib7 8191 6 in in IN cord-005453-4057qib7 8191 7 steps step NNS cord-005453-4057qib7 8191 8 II II NNP cord-005453-4057qib7 8191 9 and and CC cord-005453-4057qib7 8191 10 IV IV NNP cord-005453-4057qib7 8191 11 , , , cord-005453-4057qib7 8191 12 median median JJ cord-005453-4057qib7 8191 13 costs cost NNS cord-005453-4057qib7 8191 14 of of IN cord-005453-4057qib7 8191 15 USD usd NN cord-005453-4057qib7 8191 16 44,274.52 44,274.52 CD cord-005453-4057qib7 8191 17 while while IN cord-005453-4057qib7 8191 18 in in IN cord-005453-4057qib7 8191 19 higher high JJR cord-005453-4057qib7 8191 20 complexity complexity NN cord-005453-4057qib7 8191 21 USD USD NNP cord-005453-4057qib7 8191 22 100,226.26 100,226.26 CD cord-005453-4057qib7 8191 23 . . . cord-005453-4057qib7 8192 1 In in IN cord-005453-4057qib7 8192 2 addition addition NN cord-005453-4057qib7 8192 3 , , , cord-005453-4057qib7 8192 4 median median JJ cord-005453-4057qib7 8192 5 costs cost NNS cord-005453-4057qib7 8192 6 of of IN cord-005453-4057qib7 8192 7 materials material NNS cord-005453-4057qib7 8192 8 and and CC cord-005453-4057qib7 8192 9 drugs drug NNS cord-005453-4057qib7 8192 10 were be VBD cord-005453-4057qib7 8192 11 USD USD NNP cord-005453-4057qib7 8192 12 13,926.02 13,926.02 CD cord-005453-4057qib7 8192 13 and and CC cord-005453-4057qib7 8192 14 USD USD NNP cord-005453-4057qib7 8192 15 181,094.15 181,094.15 CD cord-005453-4057qib7 8192 16 in in IN cord-005453-4057qib7 8192 17 lower low JJR cord-005453-4057qib7 8192 18 and and CC cord-005453-4057qib7 8192 19 higher high JJR cord-005453-4057qib7 8192 20 complexity complexity NN cord-005453-4057qib7 8192 21 patients patient NNS cord-005453-4057qib7 8192 22 . . . cord-005453-4057qib7 8193 1 Conclusions conclusion NNS cord-005453-4057qib7 8193 2 : : : cord-005453-4057qib7 8194 1 TDABC tdabc NN cord-005453-4057qib7 8194 2 method method NN cord-005453-4057qib7 8194 3 allowed allow VBD cord-005453-4057qib7 8194 4 the the DT cord-005453-4057qib7 8194 5 identification identification NN cord-005453-4057qib7 8194 6 of of IN cord-005453-4057qib7 8194 7 the the DT cord-005453-4057qib7 8194 8 moment moment NN cord-005453-4057qib7 8194 9 when when WRB cord-005453-4057qib7 8194 10 patients patient NNS cord-005453-4057qib7 8194 11 consume consume VBP cord-005453-4057qib7 8194 12 the the DT cord-005453-4057qib7 8194 13 most most JJS cord-005453-4057qib7 8194 14 resources resource NNS cord-005453-4057qib7 8194 15 . . . cord-005453-4057qib7 8195 1 Of of IN cord-005453-4057qib7 8195 2 all all PDT cord-005453-4057qib7 8195 3 the the DT cord-005453-4057qib7 8195 4 HSCT HSCT NNP cord-005453-4057qib7 8195 5 stages stage NNS cord-005453-4057qib7 8195 6 , , , cord-005453-4057qib7 8195 7 periods period NNS cord-005453-4057qib7 8195 8 of of IN cord-005453-4057qib7 8195 9 conditioning conditioning NN cord-005453-4057qib7 8195 10 and and CC cord-005453-4057qib7 8195 11 aplasia aplasia NNP cord-005453-4057qib7 8195 12 presented present VBD cord-005453-4057qib7 8195 13 higher high JJR cord-005453-4057qib7 8195 14 costs cost NNS cord-005453-4057qib7 8195 15 , , , cord-005453-4057qib7 8195 16 representing represent VBG cord-005453-4057qib7 8195 17 76.90 76.90 CD cord-005453-4057qib7 8195 18 % % NN cord-005453-4057qib7 8195 19 of of IN cord-005453-4057qib7 8195 20 the the DT cord-005453-4057qib7 8195 21 total total JJ cord-005453-4057qib7 8195 22 hospitalization hospitalization NN cord-005453-4057qib7 8195 23 value value NN cord-005453-4057qib7 8195 24 . . . cord-005453-4057qib7 8196 1 In in IN cord-005453-4057qib7 8196 2 these these DT cord-005453-4057qib7 8196 3 stages stage NNS cord-005453-4057qib7 8196 4 , , , cord-005453-4057qib7 8196 5 higher high JJR cord-005453-4057qib7 8196 6 complexity complexity NN cord-005453-4057qib7 8196 7 patients patient NNS cord-005453-4057qib7 8196 8 presented present VBD cord-005453-4057qib7 8196 9 three three CD cord-005453-4057qib7 8196 10 times time NNS cord-005453-4057qib7 8196 11 higher high JJR cord-005453-4057qib7 8196 12 the the DT cord-005453-4057qib7 8196 13 median median JJ cord-005453-4057qib7 8196 14 cost cost NN cord-005453-4057qib7 8196 15 . . . cord-005453-4057qib7 8197 1 The the DT cord-005453-4057qib7 8197 2 resources resource NNS cord-005453-4057qib7 8197 3 that that WDT cord-005453-4057qib7 8197 4 had have VBD cord-005453-4057qib7 8197 5 the the DT cord-005453-4057qib7 8197 6 greatest great JJS cord-005453-4057qib7 8197 7 impact impact NN cord-005453-4057qib7 8197 8 were be VBD cord-005453-4057qib7 8197 9 medicines medicine NNS cord-005453-4057qib7 8197 10 and and CC cord-005453-4057qib7 8197 11 medical medical JJ cord-005453-4057qib7 8197 12 materials material NNS cord-005453-4057qib7 8197 13 , , , cord-005453-4057qib7 8197 14 costing cost VBG cord-005453-4057qib7 8197 15 120 120 CD cord-005453-4057qib7 8197 16 times time NNS cord-005453-4057qib7 8197 17 more more JJR cord-005453-4057qib7 8197 18 than than IN cord-005453-4057qib7 8197 19 lower low JJR cord-005453-4057qib7 8197 20 complexity complexity NN cord-005453-4057qib7 8197 21 patients patient NNS cord-005453-4057qib7 8197 22 . . . cord-005453-4057qib7 8198 1 Conclusion conclusion NN cord-005453-4057qib7 8198 2 : : : cord-005453-4057qib7 8199 1 This this DT cord-005453-4057qib7 8199 2 study study NN cord-005453-4057qib7 8199 3 allowed allow VBD cord-005453-4057qib7 8199 4 a a DT cord-005453-4057qib7 8199 5 detailed detailed JJ cord-005453-4057qib7 8199 6 identification identification NN cord-005453-4057qib7 8199 7 of of IN cord-005453-4057qib7 8199 8 the the DT cord-005453-4057qib7 8199 9 HSCT HSCT NNP cord-005453-4057qib7 8199 10 costs cost NNS cord-005453-4057qib7 8199 11 in in IN cord-005453-4057qib7 8199 12 patients patient NNS cord-005453-4057qib7 8199 13 with with IN cord-005453-4057qib7 8199 14 different different JJ cord-005453-4057qib7 8199 15 complexity complexity NN cord-005453-4057qib7 8199 16 ranges range VBZ cord-005453-4057qib7 8199 17 in in IN cord-005453-4057qib7 8199 18 two two CD cord-005453-4057qib7 8199 19 hospitals hospital NNS cord-005453-4057qib7 8199 20 from from IN cord-005453-4057qib7 8199 21 southern southern JJ cord-005453-4057qib7 8199 22 Brazil Brazil NNP cord-005453-4057qib7 8199 23 . . . cord-005453-4057qib7 8200 1 Therefore therefore RB cord-005453-4057qib7 8200 2 , , , cord-005453-4057qib7 8200 3 the the DT cord-005453-4057qib7 8200 4 identification identification NN cord-005453-4057qib7 8200 5 of of IN cord-005453-4057qib7 8200 6 service service NN cord-005453-4057qib7 8200 7 demand demand NN cord-005453-4057qib7 8200 8 regarding regard VBG cord-005453-4057qib7 8200 9 the the DT cord-005453-4057qib7 8200 10 clinical clinical JJ cord-005453-4057qib7 8200 11 complexity complexity NN cord-005453-4057qib7 8200 12 , , , cord-005453-4057qib7 8200 13 allows allow VBZ cord-005453-4057qib7 8200 14 the the DT cord-005453-4057qib7 8200 15 generation generation NN cord-005453-4057qib7 8200 16 of of IN cord-005453-4057qib7 8200 17 important important JJ cord-005453-4057qib7 8200 18 information information NN cord-005453-4057qib7 8200 19 for for IN cord-005453-4057qib7 8200 20 the the DT cord-005453-4057qib7 8200 21 management management NN cord-005453-4057qib7 8200 22 of of IN cord-005453-4057qib7 8200 23 the the DT cord-005453-4057qib7 8200 24 best good JJS cord-005453-4057qib7 8200 25 care care NN cord-005453-4057qib7 8200 26 in in IN cord-005453-4057qib7 8200 27 the the DT cord-005453-4057qib7 8200 28 health health NN cord-005453-4057qib7 8200 29 service service NN cord-005453-4057qib7 8200 30 . . . cord-005453-4057qib7 8201 1 Disclosure disclosure NN cord-005453-4057qib7 8201 2 _SP cord-005453-4057qib7 8201 3 Background Background NNP cord-005453-4057qib7 8201 4 : : : cord-005453-4057qib7 8201 5 Immunodeficiency Immunodeficiency NNP cord-005453-4057qib7 8201 6 due due IN cord-005453-4057qib7 8201 7 to to IN cord-005453-4057qib7 8201 8 LRBA LRBA NNP cord-005453-4057qib7 8201 9 deficiency deficiency NN cord-005453-4057qib7 8201 10 is be VBZ cord-005453-4057qib7 8201 11 characterized characterize VBN cord-005453-4057qib7 8201 12 by by IN cord-005453-4057qib7 8201 13 hypogammaglobulinemia hypogammaglobulinemia NN cord-005453-4057qib7 8201 14 and and CC cord-005453-4057qib7 8201 15 autoimmunity autoimmunity NN cord-005453-4057qib7 8201 16 . . . cord-005453-4057qib7 8202 1 Hemolytic hemolytic JJ cord-005453-4057qib7 8202 2 anemia anemia NN cord-005453-4057qib7 8202 3 , , , cord-005453-4057qib7 8202 4 lymphadenopathy lymphadenopathy JJ cord-005453-4057qib7 8202 5 , , , cord-005453-4057qib7 8202 6 autoimmune autoimmune JJ cord-005453-4057qib7 8202 7 hepatitis hepatitis NN cord-005453-4057qib7 8202 8 and and CC cord-005453-4057qib7 8202 9 , , , cord-005453-4057qib7 8202 10 above above IN cord-005453-4057qib7 8202 11 all all DT cord-005453-4057qib7 8202 12 , , , cord-005453-4057qib7 8202 13 autoimmune autoimmune JJ cord-005453-4057qib7 8202 14 enteropathy enteropathy NNP cord-005453-4057qib7 8202 15 are be VBP cord-005453-4057qib7 8202 16 the the DT cord-005453-4057qib7 8202 17 fundamental fundamental JJ cord-005453-4057qib7 8202 18 characteristics characteristic NNS cord-005453-4057qib7 8202 19 of of IN cord-005453-4057qib7 8202 20 these these DT cord-005453-4057qib7 8202 21 patients patient NNS cord-005453-4057qib7 8202 22 together together RB cord-005453-4057qib7 8202 23 with with IN cord-005453-4057qib7 8202 24 the the DT cord-005453-4057qib7 8202 25 history history NN cord-005453-4057qib7 8202 26 of of IN cord-005453-4057qib7 8202 27 recurrent recurrent JJ cord-005453-4057qib7 8202 28 invasive invasive JJ cord-005453-4057qib7 8202 29 infections infection NNS cord-005453-4057qib7 8202 30 . . . cord-005453-4057qib7 8203 1 The the DT cord-005453-4057qib7 8203 2 therapy therapy NN cord-005453-4057qib7 8203 3 includes include VBZ cord-005453-4057qib7 8203 4 immunosuppressants immunosuppressant NNS cord-005453-4057qib7 8203 5 , , , cord-005453-4057qib7 8203 6 endovenous endovenous JJ cord-005453-4057qib7 8203 7 immunoglobulins immunoglobulin NNS cord-005453-4057qib7 8203 8 . . . cord-005453-4057qib7 8204 1 Bone bone NN cord-005453-4057qib7 8204 2 marrow marrow NN cord-005453-4057qib7 8204 3 transplantation transplantation NN cord-005453-4057qib7 8204 4 is be VBZ cord-005453-4057qib7 8204 5 the the DT cord-005453-4057qib7 8204 6 final final JJ cord-005453-4057qib7 8204 7 therapy therapy NN cord-005453-4057qib7 8204 8 of of IN cord-005453-4057qib7 8204 9 these these DT cord-005453-4057qib7 8204 10 patients patient NNS cord-005453-4057qib7 8204 11 , , , cord-005453-4057qib7 8204 12 especially especially RB cord-005453-4057qib7 8204 13 in in IN cord-005453-4057qib7 8204 14 the the DT cord-005453-4057qib7 8204 15 most most RBS cord-005453-4057qib7 8204 16 serious serious JJ cord-005453-4057qib7 8204 17 cases case NNS cord-005453-4057qib7 8204 18 and and CC cord-005453-4057qib7 8204 19 in in IN cord-005453-4057qib7 8204 20 recent recent JJ cord-005453-4057qib7 8204 21 years year NNS cord-005453-4057qib7 8204 22 , , , cord-005453-4057qib7 8204 23 also also RB cord-005453-4057qib7 8204 24 on on IN cord-005453-4057qib7 8204 25 the the DT cord-005453-4057qib7 8204 26 light light NN cord-005453-4057qib7 8204 27 of of IN cord-005453-4057qib7 8204 28 increasingly increasingly RB cord-005453-4057qib7 8204 29 targeted target VBN cord-005453-4057qib7 8204 30 conditioning conditioning NN cord-005453-4057qib7 8204 31 regimes regime NNS cord-005453-4057qib7 8204 32 , , , cord-005453-4057qib7 8204 33 it -PRON- PRP cord-005453-4057qib7 8204 34 is be VBZ cord-005453-4057qib7 8204 35 associated associate VBN cord-005453-4057qib7 8204 36 with with IN cord-005453-4057qib7 8204 37 ever ever RB cord-005453-4057qib7 8204 38 better well JJR cord-005453-4057qib7 8204 39 prognosis prognosis NN cord-005453-4057qib7 8204 40 . . . cord-005453-4057qib7 8205 1 Methods method NNS cord-005453-4057qib7 8205 2 : : : cord-005453-4057qib7 8205 3 We -PRON- PRP cord-005453-4057qib7 8205 4 present present VBP cord-005453-4057qib7 8205 5 the the DT cord-005453-4057qib7 8205 6 case case NN cord-005453-4057qib7 8205 7 of of IN cord-005453-4057qib7 8205 8 Caterina Caterina NNP cord-005453-4057qib7 8205 9 , , , cord-005453-4057qib7 8205 10 an an DT cord-005453-4057qib7 8205 11 8-year 8-year JJ cord-005453-4057qib7 8205 12 - - HYPH cord-005453-4057qib7 8205 13 old old JJ cord-005453-4057qib7 8205 14 patient patient NN cord-005453-4057qib7 8205 15 with with IN cord-005453-4057qib7 8205 16 LRBA LRBA NNP cord-005453-4057qib7 8205 17 deficiency deficiency NN cord-005453-4057qib7 8205 18 , , , cord-005453-4057qib7 8205 19 diagnosed diagnose VBN cord-005453-4057qib7 8205 20 at at IN cord-005453-4057qib7 8205 21 5 5 CD cord-005453-4057qib7 8205 22 years year NNS cord-005453-4057qib7 8205 23 of of IN cord-005453-4057qib7 8205 24 age age NN cord-005453-4057qib7 8205 25 for for IN cord-005453-4057qib7 8205 26 a a DT cord-005453-4057qib7 8205 27 history history NN cord-005453-4057qib7 8205 28 of of IN cord-005453-4057qib7 8205 29 hypogammaglobulinemia hypogammaglobulinemia NN cord-005453-4057qib7 8205 30 , , , cord-005453-4057qib7 8205 31 recurring recur VBG cord-005453-4057qib7 8205 32 invasive invasive JJ cord-005453-4057qib7 8205 33 , , , cord-005453-4057qib7 8205 34 bacterial bacterial JJ cord-005453-4057qib7 8205 35 and and CC cord-005453-4057qib7 8205 36 fungal fungal JJ cord-005453-4057qib7 8205 37 infections infection NNS cord-005453-4057qib7 8205 38 and and CC cord-005453-4057qib7 8205 39 a a DT cord-005453-4057qib7 8205 40 picture picture NN cord-005453-4057qib7 8205 41 of of IN cord-005453-4057qib7 8205 42 autoimmunity autoimmunity NN cord-005453-4057qib7 8205 43 represented represent VBN cord-005453-4057qib7 8205 44 by by IN cord-005453-4057qib7 8205 45 AHIA AHIA NNP cord-005453-4057qib7 8205 46 , , , cord-005453-4057qib7 8205 47 myelitis myelitis NNP cord-005453-4057qib7 8205 48 ( ( -LRB- cord-005453-4057qib7 8205 49 C3-C5 C3-C5 NNP cord-005453-4057qib7 8205 50 ) ) -RRB- cord-005453-4057qib7 8205 51 , , , cord-005453-4057qib7 8205 52 autoimmune autoimmune JJ cord-005453-4057qib7 8205 53 hepatitis hepatitis NN cord-005453-4057qib7 8205 54 and and CC cord-005453-4057qib7 8205 55 enteropathy enteropathy NNP cord-005453-4057qib7 8205 56 in in IN cord-005453-4057qib7 8205 57 treatment treatment NN cord-005453-4057qib7 8205 58 with with IN cord-005453-4057qib7 8205 59 abatacept abatacept NNP cord-005453-4057qib7 8205 60 and and CC cord-005453-4057qib7 8205 61 sirolimus sirolimus NNP cord-005453-4057qib7 8205 62 . . . cord-005453-4057qib7 8206 1 It -PRON- PRP cord-005453-4057qib7 8206 2 also also RB cord-005453-4057qib7 8206 3 presents present VBZ cord-005453-4057qib7 8206 4 leptin leptin NN cord-005453-4057qib7 8206 5 deficiency deficiency NN cord-005453-4057qib7 8206 6 lipodystrophy lipodystrophy NNP cord-005453-4057qib7 8206 7 . . . cord-005453-4057qib7 8207 1 She -PRON- PRP cord-005453-4057qib7 8207 2 presented present VBD cord-005453-4057qib7 8207 3 to to IN cord-005453-4057qib7 8207 4 our -PRON- PRP$ cord-005453-4057qib7 8207 5 observation observation NN cord-005453-4057qib7 8207 6 for for IN cord-005453-4057qib7 8207 7 ostemielitis ostemielitis NN cord-005453-4057qib7 8207 8 in in IN cord-005453-4057qib7 8207 9 multiple multiple JJ cord-005453-4057qib7 8207 10 outbreaks outbreak NNS cord-005453-4057qib7 8207 11 ( ( -LRB- cord-005453-4057qib7 8207 12 tibia tibia NN cord-005453-4057qib7 8207 13 , , , cord-005453-4057qib7 8207 14 femur femur NN cord-005453-4057qib7 8207 15 and and CC cord-005453-4057qib7 8207 16 left leave VBD cord-005453-4057qib7 8207 17 knee knee NN cord-005453-4057qib7 8207 18 ) ) -RRB- cord-005453-4057qib7 8207 19 secondary secondary JJ cord-005453-4057qib7 8207 20 to to IN cord-005453-4057qib7 8207 21 sepsis sepsis NN cord-005453-4057qib7 8207 22 from from IN cord-005453-4057qib7 8207 23 MRSA MRSA NNP cord-005453-4057qib7 8207 24 . . . cord-005453-4057qib7 8208 1 Broad broad JJ cord-005453-4057qib7 8208 2 spectrum spectrum NN cord-005453-4057qib7 8208 3 antibiotic antibiotic NN cord-005453-4057qib7 8208 4 therapy therapy NN cord-005453-4057qib7 8208 5 and and CC cord-005453-4057qib7 8208 6 curettage curettage NN cord-005453-4057qib7 8208 7 surgery surgery NN cord-005453-4057qib7 8208 8 were be VBD cord-005453-4057qib7 8208 9 performed perform VBN cord-005453-4057qib7 8208 10 during during IN cord-005453-4057qib7 8208 11 hospitalization hospitalization NN cord-005453-4057qib7 8208 12 . . . cord-005453-4057qib7 8209 1 After after IN cord-005453-4057qib7 8209 2 5 5 CD cord-005453-4057qib7 8209 3 months month NNS cord-005453-4057qib7 8209 4 of of IN cord-005453-4057qib7 8209 5 broad broad JJ cord-005453-4057qib7 8209 6 - - HYPH cord-005453-4057qib7 8209 7 spectrum spectrum NN cord-005453-4057qib7 8209 8 antibiotic antibiotic NN cord-005453-4057qib7 8209 9 therapy therapy NN cord-005453-4057qib7 8209 10 ( ( -LRB- cord-005453-4057qib7 8209 11 daptomycin daptomycin NNS cord-005453-4057qib7 8209 12 , , , cord-005453-4057qib7 8209 13 rifampicin rifampicin NNS cord-005453-4057qib7 8209 14 , , , cord-005453-4057qib7 8209 15 ceftaroline ceftaroline NNP cord-005453-4057qib7 8209 16 , , , cord-005453-4057qib7 8209 17 cotrimoxazole cotrimoxazole NNP cord-005453-4057qib7 8209 18 , , , cord-005453-4057qib7 8209 19 levofloxacin levofloxacin NNP cord-005453-4057qib7 8209 20 , , , cord-005453-4057qib7 8209 21 dalbavancin dalbavancin NNS cord-005453-4057qib7 8209 22 ) ) -RRB- cord-005453-4057qib7 8209 23 there there EX cord-005453-4057qib7 8209 24 was be VBD cord-005453-4057qib7 8209 25 resolution resolution NN cord-005453-4057qib7 8209 26 of of IN cord-005453-4057qib7 8209 27 the the DT cord-005453-4057qib7 8209 28 infections infection NNS cord-005453-4057qib7 8209 29 . . . cord-005453-4057qib7 8210 1 Because because IN cord-005453-4057qib7 8210 2 of of IN cord-005453-4057qib7 8210 3 the the DT cord-005453-4057qib7 8210 4 seriousness seriousness NN cord-005453-4057qib7 8210 5 of of IN cord-005453-4057qib7 8210 6 the the DT cord-005453-4057qib7 8210 7 disease disease NN cord-005453-4057qib7 8210 8 it -PRON- PRP cord-005453-4057qib7 8210 9 is be VBZ cord-005453-4057qib7 8210 10 therefore therefore RB cord-005453-4057qib7 8210 11 decided decide VBN cord-005453-4057qib7 8210 12 to to TO cord-005453-4057qib7 8210 13 subject subject VB cord-005453-4057qib7 8210 14 Catherine Catherine NNP cord-005453-4057qib7 8210 15 to to IN cord-005453-4057qib7 8210 16 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 8210 17 Stem Stem NNP cord-005453-4057qib7 8210 18 Cell Cell NNP cord-005453-4057qib7 8210 19 Transplantation transplantation NN cord-005453-4057qib7 8210 20 . . . cord-005453-4057qib7 8211 1 Results result NNS cord-005453-4057qib7 8211 2 : : : cord-005453-4057qib7 8212 1 Therefore therefore RB cord-005453-4057qib7 8212 2 were be VBD cord-005453-4057qib7 8212 3 performed perform VBN cord-005453-4057qib7 8212 4 bone bone NN cord-005453-4057qib7 8212 5 marrow marrow NN cord-005453-4057qib7 8212 6 transplant transplant NN cord-005453-4057qib7 8212 7 from from IN cord-005453-4057qib7 8212 8 MUD mud NN cord-005453-4057qib7 8212 9 after after IN cord-005453-4057qib7 8212 10 conditioning conditioning NN cord-005453-4057qib7 8212 11 at at IN cord-005453-4057qib7 8212 12 reduced reduce VBN cord-005453-4057qib7 8212 13 intensity intensity NN cord-005453-4057qib7 8212 14 , , , cord-005453-4057qib7 8212 15 delayed delay VBN cord-005453-4057qib7 8212 16 in in IN cord-005453-4057qib7 8212 17 9 9 CD cord-005453-4057qib7 8212 18 days day NNS cord-005453-4057qib7 8212 19 , , , cord-005453-4057qib7 8212 20 with with IN cord-005453-4057qib7 8212 21 treosulfan treosulfan NNP cord-005453-4057qib7 8212 22 , , , cord-005453-4057qib7 8212 23 fludarabine fludarabine NNP cord-005453-4057qib7 8212 24 and and CC cord-005453-4057qib7 8212 25 thiotepa thiotepa NN cord-005453-4057qib7 8212 26 . . . cord-005453-4057qib7 8213 1 Prophylaxis prophylaxis NN cord-005453-4057qib7 8213 2 for for IN cord-005453-4057qib7 8213 3 GVHD GVHD NNP cord-005453-4057qib7 8213 4 was be VBD cord-005453-4057qib7 8213 5 performed perform VBN cord-005453-4057qib7 8213 6 with with IN cord-005453-4057qib7 8213 7 ATG ATG NNP cord-005453-4057qib7 8213 8 ( ( -LRB- cord-005453-4057qib7 8213 9 5 5 CD cord-005453-4057qib7 8213 10 mg mg NNP cord-005453-4057qib7 8213 11 / / SYM cord-005453-4057qib7 8213 12 kg kg NNP cord-005453-4057qib7 8213 13 / / SYM cord-005453-4057qib7 8213 14 day day NN cord-005453-4057qib7 8213 15 ) ) -RRB- cord-005453-4057qib7 8213 16 , , , cord-005453-4057qib7 8213 17 sirolimus sirolimus NNP cord-005453-4057qib7 8213 18 ( ( -LRB- cord-005453-4057qib7 8213 19 already already RB cord-005453-4057qib7 8213 20 practiced practice VBN cord-005453-4057qib7 8213 21 for for IN cord-005453-4057qib7 8213 22 enteropathy enteropathy NNP cord-005453-4057qib7 8213 23 ) ) -RRB- cord-005453-4057qib7 8213 24 and and CC cord-005453-4057qib7 8213 25 MMF mmf NN cord-005453-4057qib7 8213 26 . . . cord-005453-4057qib7 8214 1 Because because IN cord-005453-4057qib7 8214 2 of of IN cord-005453-4057qib7 8214 3 the the DT cord-005453-4057qib7 8214 4 hepatic hepatic JJ cord-005453-4057qib7 8214 5 picture picture NN cord-005453-4057qib7 8214 6 , , , cord-005453-4057qib7 8214 7 we -PRON- PRP cord-005453-4057qib7 8214 8 also also RB cord-005453-4057qib7 8214 9 performed perform VBD cord-005453-4057qib7 8214 10 prophylaxis prophylaxis NN cord-005453-4057qib7 8214 11 for for IN cord-005453-4057qib7 8214 12 VOD VOD NNP cord-005453-4057qib7 8214 13 with with IN cord-005453-4057qib7 8214 14 defibrotide defibrotide NN cord-005453-4057qib7 8214 15 for for IN cord-005453-4057qib7 8214 16 21 21 CD cord-005453-4057qib7 8214 17 days day NNS cord-005453-4057qib7 8214 18 . . . cord-005453-4057qib7 8215 1 Transplantation transplantation NN cord-005453-4057qib7 8215 2 was be VBD cord-005453-4057qib7 8215 3 performed perform VBN cord-005453-4057qib7 8215 4 by by IN cord-005453-4057qib7 8215 5 peripheral peripheral JJ cord-005453-4057qib7 8215 6 stem stem NN cord-005453-4057qib7 8215 7 cells cell NNS cord-005453-4057qib7 8215 8 with with IN cord-005453-4057qib7 8215 9 18 18 CD cord-005453-4057qib7 8215 10 x x SYM cord-005453-4057qib7 8215 11 10 10 CD cord-005453-4057qib7 8215 12 ^ ^ SYM cord-005453-4057qib7 8215 13 6 6 CD cord-005453-4057qib7 8215 14 CD34 CD34 NNP cord-005453-4057qib7 8215 15 / / SYM cord-005453-4057qib7 8215 16 kg kg NNS cord-005453-4057qib7 8215 17 and and CC cord-005453-4057qib7 8215 18 30 30 CD cord-005453-4057qib7 8215 19 x x SYM cord-005453-4057qib7 8215 20 10 10 CD cord-005453-4057qib7 8215 21 ^ ^ SYM cord-005453-4057qib7 8215 22 6 6 CD cord-005453-4057qib7 8215 23 CD3 CD3 NNP cord-005453-4057qib7 8215 24 / / SYM cord-005453-4057qib7 8215 25 kg kg NNP cord-005453-4057qib7 8215 26 . . . cord-005453-4057qib7 8216 1 The the DT cord-005453-4057qib7 8216 2 patient patient NN cord-005453-4057qib7 8216 3 had have VBD cord-005453-4057qib7 8216 4 always always RB cord-005453-4057qib7 8216 5 presented present VBN cord-005453-4057qib7 8216 6 good good JJ cord-005453-4057qib7 8216 7 general general JJ cord-005453-4057qib7 8216 8 conditions condition NNS cord-005453-4057qib7 8216 9 with with IN cord-005453-4057qib7 8216 10 engrafment engrafment NN cord-005453-4057qib7 8216 11 of of IN cord-005453-4057qib7 8216 12 the the DT cord-005453-4057qib7 8216 13 PMN PMN NNP cord-005453-4057qib7 8216 14 to to IN cord-005453-4057qib7 8216 15 the the DT cord-005453-4057qib7 8216 16 D d NN cord-005453-4057qib7 8216 17 + + SYM cord-005453-4057qib7 8216 18 13 13 CD cord-005453-4057qib7 8216 19 and and CC cord-005453-4057qib7 8216 20 the the DT cord-005453-4057qib7 8216 21 PLT PLT NNP cord-005453-4057qib7 8216 22 to to IN cord-005453-4057qib7 8216 23 the the DT cord-005453-4057qib7 8216 24 D d NN cord-005453-4057qib7 8216 25 + + SYM cord-005453-4057qib7 8216 26 11 11 CD cord-005453-4057qib7 8216 27 . . . cord-005453-4057qib7 8217 1 The the DT cord-005453-4057qib7 8217 2 chimerism chimerism NN cord-005453-4057qib7 8217 3 at at IN cord-005453-4057qib7 8217 4 D d NN cord-005453-4057qib7 8217 5 + + CC cord-005453-4057qib7 8217 6 20 20 CD cord-005453-4057qib7 8217 7 was be VBD cord-005453-4057qib7 8217 8 100 100 CD cord-005453-4057qib7 8217 9 % % NN cord-005453-4057qib7 8217 10 donor donor NN cord-005453-4057qib7 8217 11 both both DT cord-005453-4057qib7 8217 12 on on IN cord-005453-4057qib7 8217 13 PMN PMN NNP cord-005453-4057qib7 8217 14 and and CC cord-005453-4057qib7 8217 15 on on IN cord-005453-4057qib7 8217 16 PBL PBL NNP cord-005453-4057qib7 8217 17 . . . cord-005453-4057qib7 8218 1 Prophylaxis prophylaxis NN cord-005453-4057qib7 8218 2 for for IN cord-005453-4057qib7 8218 3 GVHD GVHD NNP cord-005453-4057qib7 8218 4 was be VBD cord-005453-4057qib7 8218 5 changed change VBN cord-005453-4057qib7 8218 6 on on IN cord-005453-4057qib7 8218 7 D D NNP cord-005453-4057qib7 8218 8 + + CC cord-005453-4057qib7 8218 9 7 7 CD cord-005453-4057qib7 8218 10 by by IN cord-005453-4057qib7 8218 11 replacing replace VBG cord-005453-4057qib7 8218 12 the the DT cord-005453-4057qib7 8218 13 sirolimus sirolimus NN cord-005453-4057qib7 8218 14 with with IN cord-005453-4057qib7 8218 15 tacrolimus tacrolimus NNP cord-005453-4057qib7 8218 16 for for IN cord-005453-4057qib7 8218 17 the the DT cord-005453-4057qib7 8218 18 appearance appearance NN cord-005453-4057qib7 8218 19 of of IN cord-005453-4057qib7 8218 20 grade grade NN cord-005453-4057qib7 8218 21 I -PRON- PRP cord-005453-4057qib7 8218 22 cutaneous cutaneous JJ cord-005453-4057qib7 8218 23 GVHD GVHD NNP cord-005453-4057qib7 8218 24 . . . cord-005453-4057qib7 8219 1 Conclusions conclusion NNS cord-005453-4057qib7 8219 2 : : : cord-005453-4057qib7 8220 1 We -PRON- PRP cord-005453-4057qib7 8220 2 have have VBP cord-005453-4057qib7 8220 3 successfully successfully RB cord-005453-4057qib7 8220 4 performed perform VBN cord-005453-4057qib7 8220 5 bone bone NN cord-005453-4057qib7 8220 6 marrow marrow NN cord-005453-4057qib7 8220 7 transplantation transplantation NN cord-005453-4057qib7 8220 8 in in IN cord-005453-4057qib7 8220 9 patients patient NNS cord-005453-4057qib7 8220 10 with with IN cord-005453-4057qib7 8220 11 LRBA LRBA NNP cord-005453-4057qib7 8220 12 deficiency deficiency NN cord-005453-4057qib7 8220 13 . . . cord-005453-4057qib7 8221 1 The the DT cord-005453-4057qib7 8221 2 new new JJ cord-005453-4057qib7 8221 3 antibiotic antibiotic JJ cord-005453-4057qib7 8221 4 molecules molecule NNS cord-005453-4057qib7 8221 5 , , , cord-005453-4057qib7 8221 6 used use VBN cord-005453-4057qib7 8221 7 to to TO cord-005453-4057qib7 8221 8 induce induce VB cord-005453-4057qib7 8221 9 infectious infectious JJ cord-005453-4057qib7 8221 10 remission remission NN cord-005453-4057qib7 8221 11 , , , cord-005453-4057qib7 8221 12 the the DT cord-005453-4057qib7 8221 13 new new JJ cord-005453-4057qib7 8221 14 low low JJ cord-005453-4057qib7 8221 15 - - HYPH cord-005453-4057qib7 8221 16 intensity intensity NN cord-005453-4057qib7 8221 17 regimens regimen NNS cord-005453-4057qib7 8221 18 , , , cord-005453-4057qib7 8221 19 the the DT cord-005453-4057qib7 8221 20 prevention prevention NN cord-005453-4057qib7 8221 21 of of IN cord-005453-4057qib7 8221 22 the the DT cord-005453-4057qib7 8221 23 most most RBS cord-005453-4057qib7 8221 24 fearful fearful JJ cord-005453-4057qib7 8221 25 complications complication NNS cord-005453-4057qib7 8221 26 ( ( -LRB- cord-005453-4057qib7 8221 27 VOD VOD NNP cord-005453-4057qib7 8221 28 ) ) -RRB- cord-005453-4057qib7 8221 29 have have VBP cord-005453-4057qib7 8221 30 been be VBN cord-005453-4057qib7 8221 31 the the DT cord-005453-4057qib7 8221 32 key key NN cord-005453-4057qib7 8221 33 to to IN cord-005453-4057qib7 8221 34 success success NN cord-005453-4057qib7 8221 35 in in IN cord-005453-4057qib7 8221 36 such such JJ cord-005453-4057qib7 8221 37 complicated complicated JJ cord-005453-4057qib7 8221 38 case case NN cord-005453-4057qib7 8221 39 . . . cord-005453-4057qib7 8222 1 The the DT cord-005453-4057qib7 8222 2 high high JJ cord-005453-4057qib7 8222 3 number number NN cord-005453-4057qib7 8222 4 of of IN cord-005453-4057qib7 8222 5 CD34 CD34 NNP cord-005453-4057qib7 8222 6 cells cell NNS cord-005453-4057qib7 8222 7 infused infuse VBN cord-005453-4057qib7 8222 8 with with IN cord-005453-4057qib7 8222 9 a a DT cord-005453-4057qib7 8222 10 controlled control VBN cord-005453-4057qib7 8222 11 number number NN cord-005453-4057qib7 8222 12 of of IN cord-005453-4057qib7 8222 13 CD3 CD3 NNP cord-005453-4057qib7 8222 14 were be VBD cord-005453-4057qib7 8222 15 the the DT cord-005453-4057qib7 8222 16 key key NN cord-005453-4057qib7 8222 17 then then RB cord-005453-4057qib7 8222 18 of of IN cord-005453-4057qib7 8222 19 rapid rapid JJ cord-005453-4057qib7 8222 20 engraftment engraftment NN cord-005453-4057qib7 8222 21 with with IN cord-005453-4057qib7 8222 22 minimal minimal JJ cord-005453-4057qib7 8222 23 GVHD GVHD NNP cord-005453-4057qib7 8222 24 readily readily RB cord-005453-4057qib7 8222 25 controlled control VBN cord-005453-4057qib7 8222 26 by by IN cord-005453-4057qib7 8222 27 the the DT cord-005453-4057qib7 8222 28 immunosuppressant immunosuppressant NN cord-005453-4057qib7 8222 29 . . . cord-005453-4057qib7 8223 1 Disclosure disclosure NN cord-005453-4057qib7 8223 2 Background background NN cord-005453-4057qib7 8223 3 : : : cord-005453-4057qib7 8224 1 In in IN cord-005453-4057qib7 8224 2 the the DT cord-005453-4057qib7 8224 3 absence absence NN cord-005453-4057qib7 8224 4 of of IN cord-005453-4057qib7 8224 5 HLA HLA NNP cord-005453-4057qib7 8224 6 - - HYPH cord-005453-4057qib7 8224 7 matched match VBN cord-005453-4057qib7 8224 8 related related JJ cord-005453-4057qib7 8224 9 donor donor NN cord-005453-4057qib7 8224 10 , , , cord-005453-4057qib7 8224 11 allogeneic allogeneic IN cord-005453-4057qib7 8224 12 stem stem NN cord-005453-4057qib7 8224 13 cell cell NN cord-005453-4057qib7 8224 14 transplantation transplantation NN cord-005453-4057qib7 8224 15 from from IN cord-005453-4057qib7 8224 16 haploidentical haploidentical JJ cord-005453-4057qib7 8224 17 donors donor NNS cord-005453-4057qib7 8224 18 are be VBP cord-005453-4057qib7 8224 19 potential potential JJ cord-005453-4057qib7 8224 20 alternatives alternative NNS cord-005453-4057qib7 8224 21 for for IN cord-005453-4057qib7 8224 22 patients patient NNS cord-005453-4057qib7 8224 23 with with IN cord-005453-4057qib7 8224 24 hematological hematological JJ cord-005453-4057qib7 8224 25 malignencies malignencie NNS cord-005453-4057qib7 8224 26 with with IN cord-005453-4057qib7 8224 27 an an DT cord-005453-4057qib7 8224 28 indication indication NN cord-005453-4057qib7 8224 29 to to IN cord-005453-4057qib7 8224 30 allogeneic allogeneic VB cord-005453-4057qib7 8224 31 stem stem NN cord-005453-4057qib7 8224 32 cell cell NN cord-005453-4057qib7 8224 33 transplantation transplantation NN cord-005453-4057qib7 8224 34 . . . cord-005453-4057qib7 8225 1 Herein herein RB cord-005453-4057qib7 8225 2 , , , cord-005453-4057qib7 8225 3 we -PRON- PRP cord-005453-4057qib7 8225 4 retrospectively retrospectively RB cord-005453-4057qib7 8225 5 assessed assess VBD cord-005453-4057qib7 8225 6 the the DT cord-005453-4057qib7 8225 7 outcome outcome NN cord-005453-4057qib7 8225 8 of of IN cord-005453-4057qib7 8225 9 haplo haplo NNP cord-005453-4057qib7 8225 10 - - HYPH cord-005453-4057qib7 8225 11 SCT SCT NNP cord-005453-4057qib7 8225 12 for for IN cord-005453-4057qib7 8225 13 patients patient NNS cord-005453-4057qib7 8225 14 with with IN cord-005453-4057qib7 8225 15 refractory refractory JJ cord-005453-4057qib7 8225 16 hematological hematological JJ cord-005453-4057qib7 8225 17 malignancies malignancy NNS cord-005453-4057qib7 8225 18 . . . cord-005453-4057qib7 8226 1 Methods method NNS cord-005453-4057qib7 8226 2 : : : cord-005453-4057qib7 8227 1 This this DT cord-005453-4057qib7 8227 2 analysis analysis NN cord-005453-4057qib7 8227 3 included include VBD cord-005453-4057qib7 8227 4 27 27 CD cord-005453-4057qib7 8227 5 consecutive consecutive JJ cord-005453-4057qib7 8227 6 patients patient NNS cord-005453-4057qib7 8227 7 who who WP cord-005453-4057qib7 8227 8 underwent undergo VBD cord-005453-4057qib7 8227 9 haplo haplo NNP cord-005453-4057qib7 8227 10 - - HYPH cord-005453-4057qib7 8227 11 SCT SCT NNP cord-005453-4057qib7 8227 12 for for IN cord-005453-4057qib7 8227 13 various various JJ cord-005453-4057qib7 8227 14 hematological hematological JJ cord-005453-4057qib7 8227 15 malignancies malignancy NNS cord-005453-4057qib7 8227 16 at at IN cord-005453-4057qib7 8227 17 our -PRON- PRP$ cord-005453-4057qib7 8227 18 center center NN cord-005453-4057qib7 8227 19 between between IN cord-005453-4057qib7 8227 20 October October NNP cord-005453-4057qib7 8227 21 2010 2010 CD cord-005453-4057qib7 8227 22 and and CC cord-005453-4057qib7 8227 23 May May NNP cord-005453-4057qib7 8227 24 2018 2018 CD cord-005453-4057qib7 8227 25 . . . cord-005453-4057qib7 8228 1 We -PRON- PRP cord-005453-4057qib7 8228 2 used use VBD cord-005453-4057qib7 8228 3 our -PRON- PRP$ cord-005453-4057qib7 8228 4 institutional institutional JJ cord-005453-4057qib7 8228 5 database database NN cord-005453-4057qib7 8228 6 to to TO cord-005453-4057qib7 8228 7 evaluate evaluate VB cord-005453-4057qib7 8228 8 details detail NNS cord-005453-4057qib7 8228 9 and and CC cord-005453-4057qib7 8228 10 characteristics characteristic NNS cord-005453-4057qib7 8228 11 of of IN cord-005453-4057qib7 8228 12 patients patient NNS cord-005453-4057qib7 8228 13 and and CC cord-005453-4057qib7 8228 14 transplant transplant NN cord-005453-4057qib7 8228 15 outcomes outcome NNS cord-005453-4057qib7 8228 16 . . . cord-005453-4057qib7 8229 1 Results result NNS cord-005453-4057qib7 8229 2 : : : cord-005453-4057qib7 8230 1 Demographic demographic JJ cord-005453-4057qib7 8230 2 features feature NNS cord-005453-4057qib7 8230 3 of of IN cord-005453-4057qib7 8230 4 the the DT cord-005453-4057qib7 8230 5 patients patient NNS cord-005453-4057qib7 8230 6 and and CC cord-005453-4057qib7 8230 7 donors donor NNS cord-005453-4057qib7 8230 8 have have VBP cord-005453-4057qib7 8230 9 been be VBN cord-005453-4057qib7 8230 10 summarized summarize VBN cord-005453-4057qib7 8230 11 in in IN cord-005453-4057qib7 8230 12 Table Table NNP cord-005453-4057qib7 8230 13 1 1 CD cord-005453-4057qib7 8230 14 . . . cord-005453-4057qib7 8231 1 All all DT cord-005453-4057qib7 8231 2 of of IN cord-005453-4057qib7 8231 3 the the DT cord-005453-4057qib7 8231 4 patients patient NNS cord-005453-4057qib7 8231 5 had have VBD cord-005453-4057qib7 8231 6 advanced advanced JJ cord-005453-4057qib7 8231 7 disease disease NN cord-005453-4057qib7 8231 8 with with IN cord-005453-4057qib7 8231 9 a a DT cord-005453-4057qib7 8231 10 high high JJ cord-005453-4057qib7 8231 11 risk risk NN cord-005453-4057qib7 8231 12 of of IN cord-005453-4057qib7 8231 13 relapse relapse NN cord-005453-4057qib7 8231 14 . . . cord-005453-4057qib7 8232 1 The the DT cord-005453-4057qib7 8232 2 majority majority NN cord-005453-4057qib7 8232 3 of of IN cord-005453-4057qib7 8232 4 patients patient NNS cord-005453-4057qib7 8232 5 underwent undergo VBD cord-005453-4057qib7 8232 6 haplo haplo NNP cord-005453-4057qib7 8232 7 - - HYPH cord-005453-4057qib7 8232 8 SCT SCT NNP cord-005453-4057qib7 8232 9 from from IN cord-005453-4057qib7 8232 10 their -PRON- PRP$ cord-005453-4057qib7 8232 11 parents parent NNS cord-005453-4057qib7 8232 12 . . . cord-005453-4057qib7 8233 1 Out out IN cord-005453-4057qib7 8233 2 of of IN cord-005453-4057qib7 8233 3 24 24 CD cord-005453-4057qib7 8233 4 patients patient NNS cord-005453-4057qib7 8233 5 , , , cord-005453-4057qib7 8233 6 early early JJ cord-005453-4057qib7 8233 7 transplant transplant NN cord-005453-4057qib7 8233 8 - - HYPH cord-005453-4057qib7 8233 9 related relate VBN cord-005453-4057qib7 8233 10 mortality mortality NN cord-005453-4057qib7 8233 11 was be VBD cord-005453-4057qib7 8233 12 seen see VBN cord-005453-4057qib7 8233 13 in in IN cord-005453-4057qib7 8233 14 this this DT cord-005453-4057qib7 8233 15 cohort cohort NN cord-005453-4057qib7 8233 16 of of IN cord-005453-4057qib7 8233 17 5 5 CD cord-005453-4057qib7 8233 18 patients patient NNS cord-005453-4057qib7 8233 19 . . . cord-005453-4057qib7 8234 1 Four four CD cord-005453-4057qib7 8234 2 patients patient NNS cord-005453-4057qib7 8234 3 treated treat VBN cord-005453-4057qib7 8234 4 with with IN cord-005453-4057qib7 8234 5 second second JJ cord-005453-4057qib7 8234 6 haplo haplo NNP cord-005453-4057qib7 8234 7 - - HYPH cord-005453-4057qib7 8234 8 SCT SCT NNP cord-005453-4057qib7 8234 9 and and CC cord-005453-4057qib7 8234 10 recovered recover VBD cord-005453-4057qib7 8234 11 hematopoiesis hematopoiesis NN cord-005453-4057qib7 8234 12 after after IN cord-005453-4057qib7 8234 13 second second JJ cord-005453-4057qib7 8234 14 transplant transplant NN cord-005453-4057qib7 8234 15 . . . cord-005453-4057qib7 8235 1 The the DT cord-005453-4057qib7 8235 2 remaining remain VBG cord-005453-4057qib7 8235 3 19 19 CD cord-005453-4057qib7 8235 4 patients patient NNS cord-005453-4057qib7 8235 5 were be VBD cord-005453-4057qib7 8235 6 followed follow VBN cord-005453-4057qib7 8235 7 in in IN cord-005453-4057qib7 8235 8 a a DT cord-005453-4057qib7 8235 9 median median NN cord-005453-4057qib7 8235 10 of of IN cord-005453-4057qib7 8235 11 4 4 CD cord-005453-4057qib7 8235 12 months month NNS cord-005453-4057qib7 8235 13 . . . cord-005453-4057qib7 8236 1 Donor donor NN cord-005453-4057qib7 8236 2 type type NN cord-005453-4057qib7 8236 3 ABO ABO NNP cord-005453-4057qib7 8236 4 group group NN cord-005453-4057qib7 8236 5 switch switch NN cord-005453-4057qib7 8236 6 was be VBD cord-005453-4057qib7 8236 7 observed observe VBN cord-005453-4057qib7 8236 8 in in IN cord-005453-4057qib7 8236 9 a a DT cord-005453-4057qib7 8236 10 median median NN cord-005453-4057qib7 8236 11 of of IN cord-005453-4057qib7 8236 12 45 45 CD cord-005453-4057qib7 8236 13 days day NNS cord-005453-4057qib7 8236 14 ( ( -LRB- cord-005453-4057qib7 8236 15 30 30 CD cord-005453-4057qib7 8236 16 - - SYM cord-005453-4057qib7 8236 17 60 60 CD cord-005453-4057qib7 8236 18 days day NNS cord-005453-4057qib7 8236 19 ) ) -RRB- cord-005453-4057qib7 8236 20 after after IN cord-005453-4057qib7 8236 21 transplant transplant NN cord-005453-4057qib7 8236 22 . . . cord-005453-4057qib7 8237 1 The the DT cord-005453-4057qib7 8237 2 median median JJ cord-005453-4057qib7 8237 3 time time NN cord-005453-4057qib7 8237 4 for for IN cord-005453-4057qib7 8237 5 engraftment engraftment NN cord-005453-4057qib7 8237 6 was be VBD cord-005453-4057qib7 8237 7 19 19 CD cord-005453-4057qib7 8237 8 days day NNS cord-005453-4057qib7 8237 9 ( ( -LRB- cord-005453-4057qib7 8237 10 range range NN cord-005453-4057qib7 8237 11 , , , cord-005453-4057qib7 8237 12 15 15 CD cord-005453-4057qib7 8237 13 - - SYM cord-005453-4057qib7 8237 14 60 60 CD cord-005453-4057qib7 8237 15 ) ) -RRB- cord-005453-4057qib7 8237 16 for for IN cord-005453-4057qib7 8237 17 all all DT cord-005453-4057qib7 8237 18 patients patient NNS cord-005453-4057qib7 8237 19 . . . cord-005453-4057qib7 8238 1 After after IN cord-005453-4057qib7 8238 2 the the DT cord-005453-4057qib7 8238 3 first first JJ cord-005453-4057qib7 8238 4 transplant transplant NN cord-005453-4057qib7 8238 5 , , , cord-005453-4057qib7 8238 6 9 9 CD cord-005453-4057qib7 8238 7 patients patient NNS cord-005453-4057qib7 8238 8 developed develop VBD cord-005453-4057qib7 8238 9 acute acute JJ cord-005453-4057qib7 8238 10 GVHD GVHD NNP cord-005453-4057qib7 8238 11 ( ( -LRB- cord-005453-4057qib7 8238 12 37.5 37.5 CD cord-005453-4057qib7 8238 13 % % NN cord-005453-4057qib7 8238 14 ) ) -RRB- cord-005453-4057qib7 8238 15 with with IN cord-005453-4057qib7 8238 16 7 7 CD cord-005453-4057qib7 8238 17 patients patient NNS cord-005453-4057qib7 8238 18 having have VBG cord-005453-4057qib7 8238 19 grade grade NN cord-005453-4057qib7 8238 20 II II NNP cord-005453-4057qib7 8238 21 - - HYPH cord-005453-4057qib7 8238 22 III iii CD cord-005453-4057qib7 8238 23 acute acute JJ cord-005453-4057qib7 8238 24 GVHD GVHD NNP cord-005453-4057qib7 8238 25 . . . cord-005453-4057qib7 8239 1 Five five CD cord-005453-4057qib7 8239 2 ( ( -LRB- cord-005453-4057qib7 8239 3 18.5 18.5 CD cord-005453-4057qib7 8239 4 % % NN cord-005453-4057qib7 8239 5 ) ) -RRB- cord-005453-4057qib7 8239 6 had have VBD cord-005453-4057qib7 8239 7 chronic chronic JJ cord-005453-4057qib7 8239 8 GVHD GVHD NNP cord-005453-4057qib7 8239 9 , , , cord-005453-4057qib7 8239 10 none none NN cord-005453-4057qib7 8239 11 of of IN cord-005453-4057qib7 8239 12 them -PRON- PRP cord-005453-4057qib7 8239 13 with with IN cord-005453-4057qib7 8239 14 extensive extensive JJ cord-005453-4057qib7 8239 15 manifestation manifestation NN cord-005453-4057qib7 8239 16 . . . cord-005453-4057qib7 8240 1 The the DT cord-005453-4057qib7 8240 2 prepative prepative JJ cord-005453-4057qib7 8240 3 regimen regimen NN cord-005453-4057qib7 8240 4 was be VBD cord-005453-4057qib7 8240 5 relatively relatively RB cord-005453-4057qib7 8240 6 well well RB cord-005453-4057qib7 8240 7 tolerated tolerate VBN cord-005453-4057qib7 8240 8 with with IN cord-005453-4057qib7 8240 9 limited limited JJ cord-005453-4057qib7 8240 10 regimen regimen NN cord-005453-4057qib7 8240 11 - - HYPH cord-005453-4057qib7 8240 12 related relate VBN cord-005453-4057qib7 8240 13 toxicity toxicity NN cord-005453-4057qib7 8240 14 . . . cord-005453-4057qib7 8241 1 CMV CMV NNP cord-005453-4057qib7 8241 2 reactivation reactivation NN cord-005453-4057qib7 8241 3 occurred occur VBD cord-005453-4057qib7 8241 4 in in IN cord-005453-4057qib7 8241 5 11 11 CD cord-005453-4057qib7 8241 6 patients patient NNS cord-005453-4057qib7 8241 7 ( ( -LRB- cord-005453-4057qib7 8241 8 40.7 40.7 CD cord-005453-4057qib7 8241 9 % % NN cord-005453-4057qib7 8241 10 ) ) -RRB- cord-005453-4057qib7 8241 11 during during IN cord-005453-4057qib7 8241 12 the the DT cord-005453-4057qib7 8241 13 follow follow NN cord-005453-4057qib7 8241 14 - - HYPH cord-005453-4057qib7 8241 15 up up NN cord-005453-4057qib7 8241 16 of of IN cord-005453-4057qib7 8241 17 the the DT cord-005453-4057qib7 8241 18 study study NN cord-005453-4057qib7 8241 19 . . . cord-005453-4057qib7 8242 1 Eight eight CD cord-005453-4057qib7 8242 2 patients patient NNS cord-005453-4057qib7 8242 3 ( ( -LRB- cord-005453-4057qib7 8242 4 29.6 29.6 CD cord-005453-4057qib7 8242 5 % % NN cord-005453-4057qib7 8242 6 ) ) -RRB- cord-005453-4057qib7 8242 7 relapsed relapse VBD cord-005453-4057qib7 8242 8 after after IN cord-005453-4057qib7 8242 9 a a DT cord-005453-4057qib7 8242 10 median median NN cord-005453-4057qib7 8242 11 of of IN cord-005453-4057qib7 8242 12 132 132 CD cord-005453-4057qib7 8242 13 days day NNS cord-005453-4057qib7 8242 14 post post NN cord-005453-4057qib7 8242 15 transplant transplant NN cord-005453-4057qib7 8242 16 ( ( -LRB- cord-005453-4057qib7 8242 17 range range NN cord-005453-4057qib7 8242 18 , , , cord-005453-4057qib7 8242 19 45 45 CD cord-005453-4057qib7 8242 20 - - SYM cord-005453-4057qib7 8242 21 588 588 CD cord-005453-4057qib7 8242 22 days day NNS cord-005453-4057qib7 8242 23 ) ) -RRB- cord-005453-4057qib7 8242 24 . . . cord-005453-4057qib7 8243 1 CR CR NNP cord-005453-4057qib7 8243 2 was be VBD cord-005453-4057qib7 8243 3 achieved achieve VBN cord-005453-4057qib7 8243 4 in in IN cord-005453-4057qib7 8243 5 17 17 CD cord-005453-4057qib7 8243 6 ( ( -LRB- cord-005453-4057qib7 8243 7 63 63 CD cord-005453-4057qib7 8243 8 % % NN cord-005453-4057qib7 8243 9 ) ) -RRB- cord-005453-4057qib7 8243 10 patients patient NNS cord-005453-4057qib7 8243 11 after after IN cord-005453-4057qib7 8243 12 haplo haplo NNP cord-005453-4057qib7 8243 13 - - HYPH cord-005453-4057qib7 8243 14 SCT SCT NNP cord-005453-4057qib7 8243 15 . . . cord-005453-4057qib7 8244 1 Mean mean JJ cord-005453-4057qib7 8244 2 estimated estimate VBD cord-005453-4057qib7 8244 3 5-year 5-year CD cord-005453-4057qib7 8244 4 OS OS NNP cord-005453-4057qib7 8244 5 and and CC cord-005453-4057qib7 8244 6 PFS PFS NNP cord-005453-4057qib7 8244 7 are be VBP cord-005453-4057qib7 8244 8 66.7%±0.9 66.7%±0.9 CD cord-005453-4057qib7 8244 9 % % NN cord-005453-4057qib7 8244 10 and and CC cord-005453-4057qib7 8244 11 92.3%±0.7 92.3%±0.7 CD cord-005453-4057qib7 8244 12 % % NN cord-005453-4057qib7 8244 13 , , , cord-005453-4057qib7 8244 14 respectively respectively RB cord-005453-4057qib7 8244 15 . . . cord-005453-4057qib7 8245 1 Conclusions conclusion NNS cord-005453-4057qib7 8245 2 : : : cord-005453-4057qib7 8246 1 Given give VBN cord-005453-4057qib7 8246 2 the the DT cord-005453-4057qib7 8246 3 growing grow VBG cord-005453-4057qib7 8246 4 data datum NNS cord-005453-4057qib7 8246 5 on on IN cord-005453-4057qib7 8246 6 the the DT cord-005453-4057qib7 8246 7 similarity similarity NN cord-005453-4057qib7 8246 8 of of IN cord-005453-4057qib7 8246 9 outcomes outcome NNS cord-005453-4057qib7 8246 10 after after IN cord-005453-4057qib7 8246 11 HLA HLA NNP cord-005453-4057qib7 8246 12 - - HYPH cord-005453-4057qib7 8246 13 matched match VBN cord-005453-4057qib7 8246 14 and and CC cord-005453-4057qib7 8246 15 haploidentical haploidentical JJ cord-005453-4057qib7 8246 16 SCT SCT NNP cord-005453-4057qib7 8246 17 , , , cord-005453-4057qib7 8246 18 further further JJ cord-005453-4057qib7 8246 19 studies study NNS cord-005453-4057qib7 8246 20 are be VBP cord-005453-4057qib7 8246 21 required require VBN cord-005453-4057qib7 8246 22 to to TO cord-005453-4057qib7 8246 23 determine determine VB cord-005453-4057qib7 8246 24 whether whether IN cord-005453-4057qib7 8246 25 factors factor NNS cord-005453-4057qib7 8246 26 may may MD cord-005453-4057qib7 8246 27 be be VB cord-005453-4057qib7 8246 28 more more RBR cord-005453-4057qib7 8246 29 important important JJ cord-005453-4057qib7 8246 30 for for IN cord-005453-4057qib7 8246 31 donor donor NN cord-005453-4057qib7 8246 32 selection selection NN cord-005453-4057qib7 8246 33 than than IN cord-005453-4057qib7 8246 34 HLAmatching hlamatche VBG cord-005453-4057qib7 8246 35 . . . cord-005453-4057qib7 8247 1 Clinical clinical JJ cord-005453-4057qib7 8247 2 Trial Trial NNP cord-005453-4057qib7 8247 3 Registry Registry NNP cord-005453-4057qib7 8247 4 : : : cord-005453-4057qib7 8248 1 -Disclosure -disclosure UH cord-005453-4057qib7 8248 2 : : : cord-005453-4057qib7 8248 3 Nothing nothing NN cord-005453-4057qib7 8248 4 to to TO cord-005453-4057qib7 8248 5 declare declare VB cord-005453-4057qib7 8248 6 Outcome outcome NN cord-005453-4057qib7 8248 7 of of IN cord-005453-4057qib7 8248 8 allogeneic allogeneic NN cord-005453-4057qib7 8248 9 stem stem NN cord-005453-4057qib7 8248 10 cell cell NN cord-005453-4057qib7 8248 11 transplantation transplantation NN cord-005453-4057qib7 8248 12 for for IN cord-005453-4057qib7 8248 13 hodgkin hodgkin NNP cord-005453-4057qib7 8248 14 and and CC cord-005453-4057qib7 8248 15 non non NNP cord-005453-4057qib7 8248 16 - - JJ cord-005453-4057qib7 8248 17 hodgkin hodgkin JJ cord-005453-4057qib7 8248 18 lymphoma lymphoma NN cord-005453-4057qib7 8248 19 : : : cord-005453-4057qib7 8248 20 Single single JJ cord-005453-4057qib7 8248 21 center center NN cord-005453-4057qib7 8248 22 experince experince NN cord-005453-4057qib7 8248 23 from from IN cord-005453-4057qib7 8248 24 Turkey Turkey NNP cord-005453-4057qib7 8248 25 Ayşe Ayşe NNP cord-005453-4057qib7 8248 26 Uysal Uysal NNP cord-005453-4057qib7 8248 27 1 1 CD cord-005453-4057qib7 8248 28 , , , cord-005453-4057qib7 8248 29 Hale Hale NNP cord-005453-4057qib7 8248 30 Bülbül Bülbül NNP cord-005453-4057qib7 8248 31 2 2 CD cord-005453-4057qib7 8248 32 , , , cord-005453-4057qib7 8248 33 Nur Nur NNP cord-005453-4057qib7 8248 34 Akad Akad NNP cord-005453-4057qib7 8248 35 Soyer Soyer NNP cord-005453-4057qib7 8248 36 2 2 CD cord-005453-4057qib7 8248 37 , , , cord-005453-4057qib7 8248 38 Mahmut Mahmut NNP cord-005453-4057qib7 8248 39 Tobu Tobu NNP cord-005453-4057qib7 8248 40 2 2 CD cord-005453-4057qib7 8248 41 , , , cord-005453-4057qib7 8248 42 Murat Murat NNP cord-005453-4057qib7 8248 43 Tombuloglu Tombuloglu NNP cord-005453-4057qib7 8248 44 2 2 CD cord-005453-4057qib7 8248 45 , , , cord-005453-4057qib7 8248 46 Guray Guray NNP cord-005453-4057qib7 8248 47 Saydam Saydam NNP cord-005453-4057qib7 8248 48 2 2 CD cord-005453-4057qib7 8248 49 , , , cord-005453-4057qib7 8248 50 Filiz Filiz NNP cord-005453-4057qib7 8248 51 Vural Vural NNP cord-005453-4057qib7 8248 52 2 2 CD cord-005453-4057qib7 8248 53 Background Background NNP cord-005453-4057qib7 8248 54 : : : cord-005453-4057qib7 8249 1 Allogeneic Allogeneic NNP cord-005453-4057qib7 8249 2 SCT SCT NNP cord-005453-4057qib7 8249 3 ( ( -LRB- cord-005453-4057qib7 8249 4 alloSCT alloSCT NNP cord-005453-4057qib7 8249 5 ) ) -RRB- cord-005453-4057qib7 8249 6 is be VBZ cord-005453-4057qib7 8249 7 generally generally RB cord-005453-4057qib7 8249 8 optionally optionally RB cord-005453-4057qib7 8249 9 treatment treatment NN cord-005453-4057qib7 8249 10 choice choice NN cord-005453-4057qib7 8249 11 for for IN cord-005453-4057qib7 8249 12 young young JJ cord-005453-4057qib7 8249 13 and and CC cord-005453-4057qib7 8249 14 fit fit JJ cord-005453-4057qib7 8249 15 patients patient NNS cord-005453-4057qib7 8249 16 with with IN cord-005453-4057qib7 8249 17 relapsed relapse VBN cord-005453-4057qib7 8249 18 / / SYM cord-005453-4057qib7 8249 19 refractory refractory JJ cord-005453-4057qib7 8249 20 lymphoma lymphoma NN cord-005453-4057qib7 8249 21 who who WP cord-005453-4057qib7 8249 22 were be VBD cord-005453-4057qib7 8249 23 heavily heavily RB cord-005453-4057qib7 8249 24 pre pre VBN cord-005453-4057qib7 8249 25 - - VBN cord-005453-4057qib7 8249 26 treated treat VBN cord-005453-4057qib7 8249 27 and and CC cord-005453-4057qib7 8249 28 after after IN cord-005453-4057qib7 8249 29 the the DT cord-005453-4057qib7 8249 30 failure failure NN cord-005453-4057qib7 8249 31 of of IN cord-005453-4057qib7 8249 32 autologous autologous JJ cord-005453-4057qib7 8249 33 stem stem NN cord-005453-4057qib7 8249 34 cell cell NN cord-005453-4057qib7 8249 35 transplantation transplantation NN cord-005453-4057qib7 8249 36 ( ( -LRB- cord-005453-4057qib7 8249 37 ASCT ASCT NNP cord-005453-4057qib7 8249 38 ) ) -RRB- cord-005453-4057qib7 8249 39 . . . cord-005453-4057qib7 8250 1 Relapse relapse VB cord-005453-4057qib7 8250 2 after after IN cord-005453-4057qib7 8250 3 ASCT ASCT NNP cord-005453-4057qib7 8250 4 is be VBZ cord-005453-4057qib7 8250 5 associated associate VBN cord-005453-4057qib7 8250 6 with with IN cord-005453-4057qib7 8250 7 a a DT cord-005453-4057qib7 8250 8 poor poor JJ cord-005453-4057qib7 8250 9 prognosis prognosis NN cord-005453-4057qib7 8250 10 and and CC cord-005453-4057qib7 8250 11 alloSCT alloSCT NNP cord-005453-4057qib7 8250 12 is be VBZ cord-005453-4057qib7 8250 13 a a DT cord-005453-4057qib7 8250 14 potentially potentially RB cord-005453-4057qib7 8250 15 curative curative JJ cord-005453-4057qib7 8250 16 therapy therapy NN cord-005453-4057qib7 8250 17 for for IN cord-005453-4057qib7 8250 18 lymphomas lymphoma NNS cord-005453-4057qib7 8250 19 which which WDT cord-005453-4057qib7 8250 20 have have VBP cord-005453-4057qib7 8250 21 relapsed relapse VBN cord-005453-4057qib7 8250 22 after after IN cord-005453-4057qib7 8250 23 ASCT ASCT NNP cord-005453-4057qib7 8250 24 . . . cord-005453-4057qib7 8251 1 Methods method NNS cord-005453-4057qib7 8251 2 : : : cord-005453-4057qib7 8251 3 In in IN cord-005453-4057qib7 8251 4 this this DT cord-005453-4057qib7 8251 5 study study NN cord-005453-4057qib7 8251 6 , , , cord-005453-4057qib7 8251 7 we -PRON- PRP cord-005453-4057qib7 8251 8 evaluated evaluate VBD cord-005453-4057qib7 8251 9 19 19 CD cord-005453-4057qib7 8251 10 patients patient NNS cord-005453-4057qib7 8251 11 with with IN cord-005453-4057qib7 8251 12 HL HL NNP cord-005453-4057qib7 8251 13 and and CC cord-005453-4057qib7 8251 14 NHL NHL NNP cord-005453-4057qib7 8251 15 who who WP cord-005453-4057qib7 8251 16 had have VBD cord-005453-4057qib7 8251 17 treated treat VBN cord-005453-4057qib7 8251 18 with with IN cord-005453-4057qib7 8251 19 allo allo NN cord-005453-4057qib7 8251 20 - - HYPH cord-005453-4057qib7 8251 21 HSCT HSCT NNP cord-005453-4057qib7 8251 22 between between IN cord-005453-4057qib7 8251 23 November November NNP cord-005453-4057qib7 8251 24 2014 2014 CD cord-005453-4057qib7 8251 25 and and CC cord-005453-4057qib7 8251 26 December December NNP cord-005453-4057qib7 8251 27 2018 2018 CD cord-005453-4057qib7 8251 28 in in IN cord-005453-4057qib7 8251 29 Ege Ege NNP cord-005453-4057qib7 8251 30 University University NNP cord-005453-4057qib7 8251 31 Adult Adult NNP cord-005453-4057qib7 8251 32 Hematology Hematology NNP cord-005453-4057qib7 8251 33 Transplantation Transplantation NNP cord-005453-4057qib7 8251 34 Unit Unit NNP cord-005453-4057qib7 8251 35 . . . cord-005453-4057qib7 8252 1 Results result NNS cord-005453-4057qib7 8252 2 : : : cord-005453-4057qib7 8253 1 Patients patient NNS cord-005453-4057qib7 8253 2 , , , cord-005453-4057qib7 8253 3 disease disease NN cord-005453-4057qib7 8253 4 and and CC cord-005453-4057qib7 8253 5 transplant transplant NN cord-005453-4057qib7 8253 6 characteristics characteristic NNS cord-005453-4057qib7 8253 7 were be VBD cord-005453-4057qib7 8253 8 illustrated illustrate VBN cord-005453-4057qib7 8253 9 in in IN cord-005453-4057qib7 8253 10 table table NN cord-005453-4057qib7 8253 11 . . . cord-005453-4057qib7 8254 1 Histologic Histologic NNP cord-005453-4057qib7 8254 2 subtype subtype NN cord-005453-4057qib7 8254 3 of of IN cord-005453-4057qib7 8254 4 NHL NHL NNP cord-005453-4057qib7 8254 5 was be VBD cord-005453-4057qib7 8254 6 evaluated evaluate VBN cord-005453-4057qib7 8254 7 as as IN cord-005453-4057qib7 8254 8 T T NNP cord-005453-4057qib7 8254 9 cell cell NN cord-005453-4057qib7 8254 10 lymphoma lymphoma NN cord-005453-4057qib7 8254 11 ( ( -LRB- cord-005453-4057qib7 8254 12 n=8;61,5 n=8;61,5 IN cord-005453-4057qib7 8254 13 % % NN cord-005453-4057qib7 8254 14 ) ) -RRB- cord-005453-4057qib7 8254 15 , , , cord-005453-4057qib7 8254 16 mantle mantle NN cord-005453-4057qib7 8254 17 cell cell NN cord-005453-4057qib7 8254 18 ( ( -LRB- cord-005453-4057qib7 8254 19 n=2;15,4 n=2;15,4 CD cord-005453-4057qib7 8254 20 % % NN cord-005453-4057qib7 8254 21 ) ) -RRB- cord-005453-4057qib7 8254 22 , , , cord-005453-4057qib7 8254 23 diffuse diffuse VB cord-005453-4057qib7 8254 24 large large JJ cord-005453-4057qib7 8254 25 B b NN cord-005453-4057qib7 8254 26 - - HYPH cord-005453-4057qib7 8254 27 cell cell NN cord-005453-4057qib7 8254 28 lymphoma lymphoma NN cord-005453-4057qib7 8254 29 ( ( -LRB- cord-005453-4057qib7 8254 30 n=2;15,4 n=2;15,4 CD cord-005453-4057qib7 8254 31 % % NN cord-005453-4057qib7 8254 32 ) ) -RRB- cord-005453-4057qib7 8254 33 and and CC cord-005453-4057qib7 8254 34 B b NN cord-005453-4057qib7 8254 35 - - HYPH cord-005453-4057qib7 8254 36 cell cell NN cord-005453-4057qib7 8254 37 lymphoma lymphoma NN cord-005453-4057qib7 8254 38 , , , cord-005453-4057qib7 8254 39 unclassifiable unclassifiable JJ cord-005453-4057qib7 8254 40 , , , cord-005453-4057qib7 8254 41 with with IN cord-005453-4057qib7 8254 42 features feature NNS cord-005453-4057qib7 8254 43 intermediate intermediate JJ cord-005453-4057qib7 8254 44 between between IN cord-005453-4057qib7 8254 45 DLBCL DLBCL NNP cord-005453-4057qib7 8254 46 and and CC cord-005453-4057qib7 8254 47 classical classical JJ cord-005453-4057qib7 8254 48 Hodgkin Hodgkin NNP cord-005453-4057qib7 8254 49 lymphoma lymphoma NN cord-005453-4057qib7 8254 50 ( ( -LRB- cord-005453-4057qib7 8254 51 n=1;7,7 n=1;7,7 NNP cord-005453-4057qib7 8254 52 % % NN cord-005453-4057qib7 8254 53 ) ) -RRB- cord-005453-4057qib7 8254 54 . . . cord-005453-4057qib7 8255 1 All all DT cord-005453-4057qib7 8255 2 histologic histologic JJ cord-005453-4057qib7 8255 3 subtype subtype NN cord-005453-4057qib7 8255 4 of of IN cord-005453-4057qib7 8255 5 HL HL NNP cord-005453-4057qib7 8255 6 was be VBD cord-005453-4057qib7 8255 7 determined determine VBN cord-005453-4057qib7 8255 8 as as IN cord-005453-4057qib7 8255 9 nodular nodular JJ cord-005453-4057qib7 8255 10 sclerosing sclerosing NN cord-005453-4057qib7 8255 11 . . . cord-005453-4057qib7 8256 1 The the DT cord-005453-4057qib7 8256 2 median median JJ cord-005453-4057qib7 8256 3 number number NN cord-005453-4057qib7 8256 4 of of IN cord-005453-4057qib7 8256 5 prior prior JJ cord-005453-4057qib7 8256 6 treatments treatment NNS cord-005453-4057qib7 8256 7 before before IN cord-005453-4057qib7 8256 8 allo allo NN cord-005453-4057qib7 8256 9 - - HYPH cord-005453-4057qib7 8256 10 HSCT HSCT NNP cord-005453-4057qib7 8256 11 was be VBD cord-005453-4057qib7 8256 12 3 3 CD cord-005453-4057qib7 8257 1 ( ( -LRB- cord-005453-4057qib7 8257 2 range range NN cord-005453-4057qib7 8257 3 , , , cord-005453-4057qib7 8257 4 1 1 CD cord-005453-4057qib7 8257 5 - - SYM cord-005453-4057qib7 8257 6 4 4 CD cord-005453-4057qib7 8257 7 ) ) -RRB- cord-005453-4057qib7 8257 8 . . . cord-005453-4057qib7 8258 1 Twelve twelve CD cord-005453-4057qib7 8258 2 ( ( -LRB- cord-005453-4057qib7 8258 3 63,2 63,2 CD cord-005453-4057qib7 8258 4 % % NN cord-005453-4057qib7 8258 5 ) ) -RRB- cord-005453-4057qib7 8258 6 patients patient NNS cord-005453-4057qib7 8258 7 had have VBD cord-005453-4057qib7 8258 8 refractory refractory JJ cord-005453-4057qib7 8258 9 disease disease NN cord-005453-4057qib7 8258 10 , , . cord-005453-4057qib7 8259 1 3 3 LS cord-005453-4057qib7 8259 2 ( ( -LRB- cord-005453-4057qib7 8259 3 15,4 15,4 CD cord-005453-4057qib7 8259 4 % % NN cord-005453-4057qib7 8259 5 ) ) -RRB- cord-005453-4057qib7 8259 6 patients patient NNS cord-005453-4057qib7 8259 7 were be VBD cord-005453-4057qib7 8259 8 in in IN cord-005453-4057qib7 8259 9 complete complete JJ cord-005453-4057qib7 8259 10 remission remission NN cord-005453-4057qib7 8259 11 and and CC cord-005453-4057qib7 8259 12 4 4 CD cord-005453-4057qib7 8259 13 ( ( -LRB- cord-005453-4057qib7 8259 14 21,1 21,1 CD cord-005453-4057qib7 8259 15 % % NN cord-005453-4057qib7 8259 16 ) ) -RRB- cord-005453-4057qib7 8259 17 patients patient NNS cord-005453-4057qib7 8259 18 were be VBD cord-005453-4057qib7 8259 19 in in IN cord-005453-4057qib7 8259 20 partial partial JJ cord-005453-4057qib7 8259 21 remission remission NN cord-005453-4057qib7 8259 22 before before IN cord-005453-4057qib7 8259 23 allo allo NN cord-005453-4057qib7 8259 24 - - HYPH cord-005453-4057qib7 8259 25 HSCT HSCT NNP cord-005453-4057qib7 8259 26 . . . cord-005453-4057qib7 8260 1 The the DT cord-005453-4057qib7 8260 2 median median JJ cord-005453-4057qib7 8260 3 time time NN cord-005453-4057qib7 8260 4 from from IN cord-005453-4057qib7 8260 5 diagnosis diagnosis NN cord-005453-4057qib7 8260 6 to to IN cord-005453-4057qib7 8260 7 alloSCT alloSCT NNP cord-005453-4057qib7 8260 8 was be VBD cord-005453-4057qib7 8260 9 24 24 CD cord-005453-4057qib7 8261 1 ( ( -LRB- cord-005453-4057qib7 8261 2 range range NN cord-005453-4057qib7 8261 3 , , , cord-005453-4057qib7 8261 4 8 8 CD cord-005453-4057qib7 8261 5 - - SYM cord-005453-4057qib7 8261 6 144 144 CD cord-005453-4057qib7 8261 7 ) ) -RRB- cord-005453-4057qib7 8261 8 months month NNS cord-005453-4057qib7 8261 9 . . . cord-005453-4057qib7 8262 1 Peripheral peripheral JJ cord-005453-4057qib7 8262 2 stem stem NN cord-005453-4057qib7 8262 3 cell cell NN cord-005453-4057qib7 8262 4 was be VBD cord-005453-4057qib7 8262 5 used use VBN cord-005453-4057qib7 8262 6 for for IN cord-005453-4057qib7 8262 7 stem stem NN cord-005453-4057qib7 8262 8 cell cell NN cord-005453-4057qib7 8262 9 source source NN cord-005453-4057qib7 8262 10 in in IN cord-005453-4057qib7 8262 11 all all DT cord-005453-4057qib7 8262 12 of of IN cord-005453-4057qib7 8262 13 them -PRON- PRP cord-005453-4057qib7 8262 14 . . . cord-005453-4057qib7 8263 1 Total total JJ cord-005453-4057qib7 8263 2 body body NN cord-005453-4057qib7 8263 3 irritation irritation NN cord-005453-4057qib7 8263 4 plus plus CC cord-005453-4057qib7 8263 5 fludarabine fludarabine NN cord-005453-4057qib7 8263 6 plus plus CC cord-005453-4057qib7 8263 7 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 8263 8 and and CC cord-005453-4057qib7 8263 9 busulfan busulfan NN cord-005453-4057qib7 8263 10 plus plus CC cord-005453-4057qib7 8263 11 cyclophosphamide cyclophosphamide NNP cord-005453-4057qib7 8263 12 were be VBD cord-005453-4057qib7 8263 13 preferred prefer VBN cord-005453-4057qib7 8263 14 most most RBS cord-005453-4057qib7 8263 15 frequently frequently RB cord-005453-4057qib7 8263 16 for for IN cord-005453-4057qib7 8263 17 conditioning conditioning NN cord-005453-4057qib7 8263 18 as as IN cord-005453-4057qib7 8263 19 non non JJ cord-005453-4057qib7 8263 20 - - JJ cord-005453-4057qib7 8263 21 myeloablative myeloablative JJ cord-005453-4057qib7 8263 22 and and CC cord-005453-4057qib7 8263 23 myeloablative myeloablative NNP cord-005453-4057qib7 8263 24 , , , cord-005453-4057qib7 8263 25 respectively respectively RB cord-005453-4057qib7 8263 26 . . . cord-005453-4057qib7 8264 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 8264 2 engraftment engraftment NN cord-005453-4057qib7 8264 3 was be VBD cord-005453-4057qib7 8264 4 occurred occur VBN cord-005453-4057qib7 8264 5 median median NN cord-005453-4057qib7 8264 6 of of IN cord-005453-4057qib7 8264 7 17 17 CD cord-005453-4057qib7 8264 8 ( ( -LRB- cord-005453-4057qib7 8264 9 range range NN cord-005453-4057qib7 8264 10 , , , cord-005453-4057qib7 8264 11 10 10 CD cord-005453-4057qib7 8264 12 - - SYM cord-005453-4057qib7 8264 13 21 21 CD cord-005453-4057qib7 8264 14 ) ) -RRB- cord-005453-4057qib7 8264 15 days day NNS cord-005453-4057qib7 8264 16 . . . cord-005453-4057qib7 8265 1 Graft graft NN cord-005453-4057qib7 8265 2 versus versus IN cord-005453-4057qib7 8265 3 host host NN cord-005453-4057qib7 8265 4 disease disease NN cord-005453-4057qib7 8265 5 ( ( -LRB- cord-005453-4057qib7 8265 6 GVHD GVHD NNP cord-005453-4057qib7 8265 7 ) ) -RRB- cord-005453-4057qib7 8265 8 prophylaxis prophylaxis NN cord-005453-4057qib7 8265 9 was be VBD cord-005453-4057qib7 8265 10 applied apply VBN cord-005453-4057qib7 8266 1 all all DT cord-005453-4057qib7 8266 2 of of IN cord-005453-4057qib7 8266 3 them -PRON- PRP cord-005453-4057qib7 8266 4 and and CC cord-005453-4057qib7 8266 5 cyclosporine cyclosporine NNP cord-005453-4057qib7 8266 6 plus plus CC cord-005453-4057qib7 8266 7 methotrexate methotrexate NNP cord-005453-4057qib7 8266 8 was be VBD cord-005453-4057qib7 8266 9 preferred prefer VBN cord-005453-4057qib7 8266 10 most most RBS cord-005453-4057qib7 8266 11 frequently frequently RB cord-005453-4057qib7 8266 12 ( ( -LRB- cord-005453-4057qib7 8266 13 n=16;84,2 n=16;84,2 CD cord-005453-4057qib7 8266 14 % % NN cord-005453-4057qib7 8266 15 ) ) -RRB- cord-005453-4057qib7 8266 16 . . . cord-005453-4057qib7 8267 1 GVHD GVHD NNP cord-005453-4057qib7 8267 2 was be VBD cord-005453-4057qib7 8267 3 occurred occur VBN cord-005453-4057qib7 8267 4 in in IN cord-005453-4057qib7 8267 5 68,4 68,4 CD cord-005453-4057qib7 8267 6 % % NN cord-005453-4057qib7 8267 7 of of IN cord-005453-4057qib7 8267 8 them -PRON- PRP cord-005453-4057qib7 8267 9 ( ( -LRB- cord-005453-4057qib7 8267 10 42,1 42,1 CD cord-005453-4057qib7 8267 11 % % NN cord-005453-4057qib7 8267 12 acute acute JJ cord-005453-4057qib7 8267 13 GVHD GVHD NNP cord-005453-4057qib7 8267 14 , , , cord-005453-4057qib7 8267 15 31,6 31,6 CD cord-005453-4057qib7 8267 16 % % NN cord-005453-4057qib7 8267 17 chronic chronic JJ cord-005453-4057qib7 8267 18 GVHD GVHD NNP cord-005453-4057qib7 8267 19 and and CC cord-005453-4057qib7 8267 20 7,7 7,7 CD cord-005453-4057qib7 8267 21 % % NN cord-005453-4057qib7 8267 22 both both DT cord-005453-4057qib7 8267 23 ) ) -RRB- cord-005453-4057qib7 8267 24 . . . cord-005453-4057qib7 8268 1 Veno Veno NNP cord-005453-4057qib7 8268 2 - - HYPH cord-005453-4057qib7 8268 3 occlusive occlusive JJ cord-005453-4057qib7 8268 4 disease disease NN cord-005453-4057qib7 8268 5 ( ( -LRB- cord-005453-4057qib7 8268 6 VOD VOD NNP cord-005453-4057qib7 8268 7 ) ) -RRB- cord-005453-4057qib7 8268 8 was be VBD cord-005453-4057qib7 8268 9 occurred occur VBN cord-005453-4057qib7 8268 10 in in IN cord-005453-4057qib7 8268 11 2 2 CD cord-005453-4057qib7 8268 12 ( ( -LRB- cord-005453-4057qib7 8268 13 10,5 10,5 CD cord-005453-4057qib7 8268 14 % % NN cord-005453-4057qib7 8268 15 ) ) -RRB- cord-005453-4057qib7 8268 16 patients patient NNS cord-005453-4057qib7 8268 17 . . . cord-005453-4057qib7 8269 1 Transplant transplant NN cord-005453-4057qib7 8269 2 related relate VBN cord-005453-4057qib7 8269 3 death death NN cord-005453-4057qib7 8269 4 was be VBD cord-005453-4057qib7 8269 5 observed observe VBN cord-005453-4057qib7 8269 6 in in IN cord-005453-4057qib7 8269 7 5 5 CD cord-005453-4057qib7 8269 8 ( ( -LRB- cord-005453-4057qib7 8269 9 26,3 26,3 CD cord-005453-4057qib7 8269 10 % % NN cord-005453-4057qib7 8269 11 ) ) -RRB- cord-005453-4057qib7 8269 12 patients patient NNS cord-005453-4057qib7 8269 13 . . . cord-005453-4057qib7 8270 1 Overall overall JJ cord-005453-4057qib7 8270 2 survival survival NN cord-005453-4057qib7 8270 3 ( ( -LRB- cord-005453-4057qib7 8270 4 OS OS NNP cord-005453-4057qib7 8270 5 ) ) -RRB- cord-005453-4057qib7 8270 6 and and CC cord-005453-4057qib7 8270 7 disease disease NN cord-005453-4057qib7 8270 8 - - HYPH cord-005453-4057qib7 8270 9 free free JJ cord-005453-4057qib7 8270 10 - - HYPH cord-005453-4057qib7 8270 11 survival survival NN cord-005453-4057qib7 8270 12 ( ( -LRB- cord-005453-4057qib7 8270 13 DFS DFS NNP cord-005453-4057qib7 8270 14 ) ) -RRB- cord-005453-4057qib7 8270 15 were be VBD cord-005453-4057qib7 8270 16 evaluated evaluate VBN cord-005453-4057qib7 8270 17 as as IN cord-005453-4057qib7 8270 18 median median NN cord-005453-4057qib7 8270 19 9 9 CD cord-005453-4057qib7 8270 20 ( ( -LRB- cord-005453-4057qib7 8270 21 range range NN cord-005453-4057qib7 8270 22 , , , cord-005453-4057qib7 8270 23 0 0 CD cord-005453-4057qib7 8270 24 - - SYM cord-005453-4057qib7 8270 25 45 45 CD cord-005453-4057qib7 8270 26 ) ) -RRB- cord-005453-4057qib7 8270 27 and and CC cord-005453-4057qib7 8270 28 7 7 CD cord-005453-4057qib7 8270 29 ( ( -LRB- cord-005453-4057qib7 8270 30 range range NN cord-005453-4057qib7 8270 31 , , , cord-005453-4057qib7 8270 32 0 0 CD cord-005453-4057qib7 8270 33 - - SYM cord-005453-4057qib7 8270 34 45 45 CD cord-005453-4057qib7 8270 35 ) ) -RRB- cord-005453-4057qib7 8270 36 months month NNS cord-005453-4057qib7 8270 37 , , , cord-005453-4057qib7 8270 38 respectively respectively RB cord-005453-4057qib7 8270 39 . . . cord-005453-4057qib7 8271 1 Analyze Analyze NNP cord-005453-4057qib7 8271 2 of of IN cord-005453-4057qib7 8271 3 OS OS NNP cord-005453-4057qib7 8271 4 and and CC cord-005453-4057qib7 8271 5 DFS DFS NNP cord-005453-4057qib7 8271 6 was be VBD cord-005453-4057qib7 8271 7 illustrated illustrate VBN cord-005453-4057qib7 8271 8 in in IN cord-005453-4057qib7 8271 9 figure figure NN cord-005453-4057qib7 8271 10 . . . cord-005453-4057qib7 8272 1 Six six CD cord-005453-4057qib7 8272 2 patients patient NNS cord-005453-4057qib7 8272 3 are be VBP cord-005453-4057qib7 8272 4 alive alive JJ cord-005453-4057qib7 8272 5 without without IN cord-005453-4057qib7 8272 6 disease disease NN cord-005453-4057qib7 8272 7 . . . cord-005453-4057qib7 8273 1 After after IN cord-005453-4057qib7 8273 2 a a DT cord-005453-4057qib7 8273 3 rapid rapid JJ cord-005453-4057qib7 8273 4 tapering tapering NN cord-005453-4057qib7 8273 5 of of IN cord-005453-4057qib7 8273 6 immunosuopressive immunosuopressive JJ cord-005453-4057qib7 8273 7 therapy therapy NN cord-005453-4057qib7 8273 8 was be VBD cord-005453-4057qib7 8273 9 underwent undergo VBN cord-005453-4057qib7 8273 10 a a DT cord-005453-4057qib7 8273 11 therapy therapy NN cord-005453-4057qib7 8273 12 with with IN cord-005453-4057qib7 8273 13 ponatinibat ponatinibat NN cord-005453-4057qib7 8273 14 dose dose NN cord-005453-4057qib7 8273 15 of of IN cord-005453-4057qib7 8273 16 45mg 45mg NN cord-005453-4057qib7 8273 17 / / SYM cord-005453-4057qib7 8273 18 die die VB cord-005453-4057qib7 8273 19 Results result NNS cord-005453-4057qib7 8273 20 : : : cord-005453-4057qib7 8273 21 Afther Afther NNP cord-005453-4057qib7 8273 22 a a DT cord-005453-4057qib7 8273 23 month month NN cord-005453-4057qib7 8273 24 of of IN cord-005453-4057qib7 8273 25 therapy therapy NN cord-005453-4057qib7 8274 1 we -PRON- PRP cord-005453-4057qib7 8274 2 observed observe VBD cord-005453-4057qib7 8274 3 a a DT cord-005453-4057qib7 8274 4 rapid rapid JJ cord-005453-4057qib7 8274 5 decrease decrease NN cord-005453-4057qib7 8274 6 in in IN cord-005453-4057qib7 8274 7 minimal minimal JJ cord-005453-4057qib7 8274 8 residual residual JJ cord-005453-4057qib7 8274 9 disease disease NN cord-005453-4057qib7 8274 10 on on IN cord-005453-4057qib7 8274 11 molecular molecular JJ cord-005453-4057qib7 8274 12 assessment assessment NN cord-005453-4057qib7 8274 13 with with IN cord-005453-4057qib7 8274 14 an an DT cord-005453-4057qib7 8274 15 MMR MMR NNP cord-005453-4057qib7 8274 16 of of IN cord-005453-4057qib7 8274 17 P190-BCR P190-BCR NNP cord-005453-4057qib7 8274 18 - - HYPH cord-005453-4057qib7 8274 19 ABL ABL NNP cord-005453-4057qib7 8274 20 / / SYM cord-005453-4057qib7 8274 21 ABL ABL NNP cord-005453-4057qib7 8275 1 non non JJ cord-005453-4057qib7 8275 2 detectable detectable JJ cord-005453-4057qib7 8275 3 confirmed confirm VBN cord-005453-4057qib7 8275 4 by by IN cord-005453-4057qib7 8275 5 bone bone NN cord-005453-4057qib7 8275 6 marrow marrow NN cord-005453-4057qib7 8275 7 revaluations revaluation NNS cord-005453-4057qib7 8275 8 at at IN cord-005453-4057qib7 8275 9 days day NNS cord-005453-4057qib7 8275 10 + + SYM cord-005453-4057qib7 8275 11 190 190 CD cord-005453-4057qib7 8275 12 , , , cord-005453-4057qib7 8275 13 +222nd +222nd NNP cord-005453-4057qib7 8275 14 +244 +244 NNP cord-005453-4057qib7 8275 15 after after IN cord-005453-4057qib7 8275 16 the the DT cord-005453-4057qib7 8275 17 salvage salvage NN cord-005453-4057qib7 8275 18 therapy therapy NN cord-005453-4057qib7 8275 19 . . . cord-005453-4057qib7 8276 1 The the DT cord-005453-4057qib7 8276 2 patient patient NN cord-005453-4057qib7 8276 3 has have VBZ cord-005453-4057qib7 8276 4 not not RB cord-005453-4057qib7 8276 5 had have VBN cord-005453-4057qib7 8276 6 experienced experience VBN cord-005453-4057qib7 8276 7 of of IN cord-005453-4057qib7 8276 8 graft graft NN cord-005453-4057qib7 8276 9 - - HYPH cord-005453-4057qib7 8276 10 versus versus IN cord-005453-4057qib7 8276 11 - - HYPH cord-005453-4057qib7 8276 12 host host NN cord-005453-4057qib7 8276 13 disease disease NN cord-005453-4057qib7 8276 14 , , , cord-005453-4057qib7 8276 15 Ponatinib Ponatinib NNP cord-005453-4057qib7 8276 16 treatment treatment NN cord-005453-4057qib7 8276 17 was be VBD cord-005453-4057qib7 8276 18 well well RB cord-005453-4057qib7 8276 19 tolerated tolerate VBN cord-005453-4057qib7 8276 20 and and CC cord-005453-4057qib7 8276 21 considered consider VBN cord-005453-4057qib7 8276 22 safe safe JJ cord-005453-4057qib7 8276 23 with with IN cord-005453-4057qib7 8276 24 easily easily RB cord-005453-4057qib7 8276 25 manageable manageable JJ cord-005453-4057qib7 8276 26 side side NN cord-005453-4057qib7 8276 27 . . . cord-005453-4057qib7 8277 1 Conclusions conclusion NNS cord-005453-4057qib7 8277 2 : : : cord-005453-4057qib7 8278 1 Maybe maybe RB cord-005453-4057qib7 8278 2 in in IN cord-005453-4057qib7 8278 3 the the DT cord-005453-4057qib7 8278 4 era era NN cord-005453-4057qib7 8278 5 of of IN cord-005453-4057qib7 8278 6 tyrosine tyrosine NN cord-005453-4057qib7 8278 7 kinase kinase NN cord-005453-4057qib7 8278 8 inhibitors inhibitor NNS cord-005453-4057qib7 8278 9 ( ( -LRB- cord-005453-4057qib7 8278 10 TKIs TKIs NNP cord-005453-4057qib7 8278 11 ) ) -RRB- cord-005453-4057qib7 8278 12 , , , cord-005453-4057qib7 8278 13 philadelphia philadelphia NNP cord-005453-4057qib7 8278 14 chromosome chromosome NN cord-005453-4057qib7 8278 15 positive positive JJ cord-005453-4057qib7 8278 16 acute acute JJ cord-005453-4057qib7 8278 17 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 8278 18 leukemia leukemia NN cord-005453-4057qib7 8278 19 ( ( -LRB- cord-005453-4057qib7 8278 20 Ph+ Ph+ NNP cord-005453-4057qib7 8278 21 ALL all DT cord-005453-4057qib7 8278 22 ) ) -RRB- cord-005453-4057qib7 8279 1 it -PRON- PRP cord-005453-4057qib7 8279 2 could could MD cord-005453-4057qib7 8279 3 benefit benefit VB cord-005453-4057qib7 8279 4 from from IN cord-005453-4057qib7 8279 5 a a DT cord-005453-4057qib7 8279 6 combined combine VBN cord-005453-4057qib7 8279 7 treatment treatment NN cord-005453-4057qib7 8279 8 between between IN cord-005453-4057qib7 8279 9 transpalnt transpalnt NN cord-005453-4057qib7 8279 10 and and CC cord-005453-4057qib7 8279 11 TKIs tki NNS cord-005453-4057qib7 8279 12 however however RB cord-005453-4057qib7 8279 13 more more JJR cord-005453-4057qib7 8279 14 studies study NNS cord-005453-4057qib7 8279 15 are be VBP cord-005453-4057qib7 8279 16 needed need VBN cord-005453-4057qib7 8279 17 to to TO cord-005453-4057qib7 8279 18 confirm confirm VB cord-005453-4057qib7 8279 19 these these DT cord-005453-4057qib7 8279 20 hypotheses hypothesis NNS cord-005453-4057qib7 8279 21 . . . cord-005453-4057qib7 8280 1 Disclosure disclosure NN cord-005453-4057qib7 8280 2 : : : cord-005453-4057qib7 8280 3 nothing nothing NN cord-005453-4057qib7 8280 4 to to TO cord-005453-4057qib7 8280 5 declare declare VB cord-005453-4057qib7 8280 6 Immunodeficiency Immunodeficiency NNP cord-005453-4057qib7 8280 7 diseases disease NNS cord-005453-4057qib7 8280 8 and and CC cord-005453-4057qib7 8280 9 macrophage macrophage NN cord-005453-4057qib7 8280 10 Background background NN cord-005453-4057qib7 8280 11 : : : cord-005453-4057qib7 8281 1 Although although IN cord-005453-4057qib7 8281 2 a a DT cord-005453-4057qib7 8281 3 number number NN cord-005453-4057qib7 8281 4 of of IN cord-005453-4057qib7 8281 5 patients patient NNS cord-005453-4057qib7 8281 6 with with IN cord-005453-4057qib7 8281 7 HIV HIV NNP cord-005453-4057qib7 8281 8 infection infection NN cord-005453-4057qib7 8281 9 and and CC cord-005453-4057qib7 8281 10 hematological hematological JJ cord-005453-4057qib7 8281 11 disease disease NN cord-005453-4057qib7 8281 12 have have VBP cord-005453-4057qib7 8281 13 successfully successfully RB cord-005453-4057qib7 8281 14 undergone undergo VBN cord-005453-4057qib7 8281 15 allogeneic allogeneic IN cord-005453-4057qib7 8281 16 HSCT HSCT NNP cord-005453-4057qib7 8281 17 together together RB cord-005453-4057qib7 8281 18 with with IN cord-005453-4057qib7 8281 19 combination combination NN cord-005453-4057qib7 8281 20 anti anti JJ cord-005453-4057qib7 8281 21 - - JJ cord-005453-4057qib7 8281 22 retroviral retroviral JJ cord-005453-4057qib7 8281 23 therapy therapy NN cord-005453-4057qib7 8281 24 ( ( -LRB- cord-005453-4057qib7 8281 25 cART cART NNP cord-005453-4057qib7 8281 26 ) ) -RRB- cord-005453-4057qib7 8281 27 , , , cord-005453-4057qib7 8281 28 short short JJ cord-005453-4057qib7 8281 29 and and CC cord-005453-4057qib7 8281 30 long long JJ cord-005453-4057qib7 8281 31 - - HYPH cord-005453-4057qib7 8281 32 term term NN cord-005453-4057qib7 8281 33 outcomes outcome NNS cord-005453-4057qib7 8281 34 remain remain VBP cord-005453-4057qib7 8281 35 not not RB cord-005453-4057qib7 8281 36 well well RB cord-005453-4057qib7 8281 37 known known JJ cord-005453-4057qib7 8281 38 . . . cord-005453-4057qib7 8282 1 We -PRON- PRP cord-005453-4057qib7 8282 2 report report VBP cord-005453-4057qib7 8282 3 the the DT cord-005453-4057qib7 8282 4 largest large JJS cord-005453-4057qib7 8282 5 Spanish spanish JJ cord-005453-4057qib7 8282 6 experience experience NN cord-005453-4057qib7 8282 7 of of IN cord-005453-4057qib7 8282 8 HIV HIV NNP cord-005453-4057qib7 8282 9 - - HYPH cord-005453-4057qib7 8282 10 infected infect VBN cord-005453-4057qib7 8282 11 adult adult NN cord-005453-4057qib7 8282 12 patients patient NNS cord-005453-4057qib7 8282 13 with with IN cord-005453-4057qib7 8282 14 high high JJ cord-005453-4057qib7 8282 15 - - HYPH cord-005453-4057qib7 8282 16 risk risk NN cord-005453-4057qib7 8282 17 hematological hematological JJ cord-005453-4057qib7 8282 18 malignancies malignancy NNS cord-005453-4057qib7 8282 19 with with IN cord-005453-4057qib7 8282 20 allogeneic allogeneic NN cord-005453-4057qib7 8282 21 HSCT HSCT NNP cord-005453-4057qib7 8282 22 . . . cord-005453-4057qib7 8283 1 Methods method NNS cord-005453-4057qib7 8284 1 : : : cord-005453-4057qib7 8284 2 We -PRON- PRP cord-005453-4057qib7 8284 3 retrospectively retrospectively RB cord-005453-4057qib7 8284 4 reviewed review VBD cord-005453-4057qib7 8284 5 22 22 CD cord-005453-4057qib7 8284 6 HIV HIV NNP cord-005453-4057qib7 8284 7 - - HYPH cord-005453-4057qib7 8284 8 positive positive JJ cord-005453-4057qib7 8284 9 patients patient NNS cord-005453-4057qib7 8284 10 who who WP cord-005453-4057qib7 8284 11 received receive VBD cord-005453-4057qib7 8284 12 allogeneic allogeneic IN cord-005453-4057qib7 8284 13 HSCT HSCT NNP cord-005453-4057qib7 8284 14 between between IN cord-005453-4057qib7 8284 15 1999 1999 CD cord-005453-4057qib7 8284 16 and and CC cord-005453-4057qib7 8284 17 2018 2018 CD cord-005453-4057qib7 8284 18 in in IN cord-005453-4057qib7 8284 19 5 5 CD cord-005453-4057qib7 8284 20 Spanish spanish JJ cord-005453-4057qib7 8284 21 centers center NNS cord-005453-4057qib7 8284 22 within within IN cord-005453-4057qib7 8284 23 GETH GETH NNP cord-005453-4057qib7 8284 24 ( ( -LRB- cord-005453-4057qib7 8284 25 Grupo Grupo NNP cord-005453-4057qib7 8284 26 Español Español NNP cord-005453-4057qib7 8284 27 de de NNP cord-005453-4057qib7 8284 28 Trasplante Trasplante NNP cord-005453-4057qib7 8284 29 Hematopoyético Hematopoyético NNP cord-005453-4057qib7 8284 30 y y NNP cord-005453-4057qib7 8284 31 Terapia Terapia NNP cord-005453-4057qib7 8284 32 Celular Celular NNP cord-005453-4057qib7 8284 33 ) ) -RRB- cord-005453-4057qib7 8284 34 . . . cord-005453-4057qib7 8285 1 Results result NNS cord-005453-4057qib7 8285 2 : : : cord-005453-4057qib7 8286 1 Baseline baseline JJ cord-005453-4057qib7 8286 2 and and CC cord-005453-4057qib7 8286 3 transplant transplant NN cord-005453-4057qib7 8286 4 characteristics characteristic NNS cord-005453-4057qib7 8286 5 of of IN cord-005453-4057qib7 8286 6 patients patient NNS cord-005453-4057qib7 8286 7 are be VBP cord-005453-4057qib7 8286 8 shown show VBN cord-005453-4057qib7 8286 9 in in IN cord-005453-4057qib7 8286 10 Table Table NNP cord-005453-4057qib7 8286 11 1 1 CD cord-005453-4057qib7 8286 12 . . . cord-005453-4057qib7 8287 1 Median median JJ cord-005453-4057qib7 8287 2 age age NN cord-005453-4057qib7 8287 3 was be VBD cord-005453-4057qib7 8287 4 44 44 CD cord-005453-4057qib7 8287 5 years year NNS cord-005453-4057qib7 8287 6 and and CC cord-005453-4057qib7 8287 7 77 77 CD cord-005453-4057qib7 8287 8 % % NN cord-005453-4057qib7 8287 9 of of IN cord-005453-4057qib7 8287 10 the the DT cord-005453-4057qib7 8287 11 patients patient NNS cord-005453-4057qib7 8287 12 were be VBD cord-005453-4057qib7 8287 13 men man NNS cord-005453-4057qib7 8287 14 . . . cord-005453-4057qib7 8288 1 The the DT cord-005453-4057qib7 8288 2 most most RBS cord-005453-4057qib7 8288 3 frequent frequent JJ cord-005453-4057qib7 8288 4 underlying underlying JJ cord-005453-4057qib7 8288 5 malignancies malignancy NNS cord-005453-4057qib7 8288 6 were be VBD cord-005453-4057qib7 8288 7 non non JJ cord-005453-4057qib7 8288 8 - - JJ cord-005453-4057qib7 8288 9 Hodgkin Hodgkin NNP cord-005453-4057qib7 8288 10 lymphoma lymphoma NN cord-005453-4057qib7 8288 11 ( ( -LRB- cord-005453-4057qib7 8288 12 9 9 CD cord-005453-4057qib7 8288 13 , , , cord-005453-4057qib7 8288 14 41 41 CD cord-005453-4057qib7 8288 15 % % NN cord-005453-4057qib7 8288 16 ) ) -RRB- cord-005453-4057qib7 8288 17 and and CC cord-005453-4057qib7 8288 18 AML AML NNP cord-005453-4057qib7 8288 19 ( ( -LRB- cord-005453-4057qib7 8288 20 7 7 CD cord-005453-4057qib7 8288 21 , , , cord-005453-4057qib7 8288 22 31 31 CD cord-005453-4057qib7 8288 23 % % NN cord-005453-4057qib7 8288 24 ) ) -RRB- cord-005453-4057qib7 8288 25 . . . cord-005453-4057qib7 8289 1 In in IN cord-005453-4057qib7 8289 2 half half NN cord-005453-4057qib7 8289 3 of of IN cord-005453-4057qib7 8289 4 the the DT cord-005453-4057qib7 8289 5 patients patient NNS cord-005453-4057qib7 8289 6 an an DT cord-005453-4057qib7 8289 7 HLAidentical HLAidentical NNP cord-005453-4057qib7 8289 8 sibling sibling NN cord-005453-4057qib7 8289 9 was be VBD cord-005453-4057qib7 8289 10 the the DT cord-005453-4057qib7 8289 11 donor donor NN cord-005453-4057qib7 8289 12 ; ; : cord-005453-4057qib7 8289 13 and and CC cord-005453-4057qib7 8289 14 in in IN cord-005453-4057qib7 8289 15 the the DT cord-005453-4057qib7 8289 16 other other JJ cord-005453-4057qib7 8289 17 half half NN cord-005453-4057qib7 8289 18 , , , cord-005453-4057qib7 8289 19 an an DT cord-005453-4057qib7 8289 20 alternative alternative JJ cord-005453-4057qib7 8289 21 donor donor NN cord-005453-4057qib7 8289 22 was be VBD cord-005453-4057qib7 8289 23 used use VBN cord-005453-4057qib7 8289 24 . . . cord-005453-4057qib7 8290 1 Peripheral peripheral JJ cord-005453-4057qib7 8290 2 blood blood NN cord-005453-4057qib7 8290 3 was be VBD cord-005453-4057qib7 8290 4 used use VBN cord-005453-4057qib7 8290 5 as as IN cord-005453-4057qib7 8290 6 graft graft NN cord-005453-4057qib7 8290 7 source source NN cord-005453-4057qib7 8290 8 in in IN cord-005453-4057qib7 8290 9 86 86 CD cord-005453-4057qib7 8290 10 % % NN cord-005453-4057qib7 8290 11 of of IN cord-005453-4057qib7 8290 12 the the DT cord-005453-4057qib7 8290 13 transplants transplant NNS cord-005453-4057qib7 8290 14 . . . cord-005453-4057qib7 8291 1 At at IN cord-005453-4057qib7 8291 2 the the DT cord-005453-4057qib7 8291 3 time time NN cord-005453-4057qib7 8291 4 of of IN cord-005453-4057qib7 8291 5 HSCT HSCT NNP cord-005453-4057qib7 8291 6 , , , cord-005453-4057qib7 8291 7 all all DT cord-005453-4057qib7 8291 8 patients patient NNS cord-005453-4057qib7 8291 9 had have VBD cord-005453-4057qib7 8291 10 been be VBN cord-005453-4057qib7 8291 11 receiving receive VBG cord-005453-4057qib7 8291 12 suppressive suppressive JJ cord-005453-4057qib7 8291 13 cART cart NN cord-005453-4057qib7 8291 14 for for IN cord-005453-4057qib7 8291 15 a a DT cord-005453-4057qib7 8291 16 median median NN cord-005453-4057qib7 8291 17 of of IN cord-005453-4057qib7 8291 18 6 6 CD cord-005453-4057qib7 8291 19 years year NNS cord-005453-4057qib7 8291 20 and and CC cord-005453-4057qib7 8291 21 only only RB cord-005453-4057qib7 8291 22 2 2 CD cord-005453-4057qib7 8291 23 of of IN cord-005453-4057qib7 8291 24 them -PRON- PRP cord-005453-4057qib7 8291 25 showed show VBD cord-005453-4057qib7 8291 26 detectable detectable JJ cord-005453-4057qib7 8291 27 plasma plasma NN cord-005453-4057qib7 8291 28 HIV HIV NNP cord-005453-4057qib7 8291 29 RNA RNA NNP cord-005453-4057qib7 8291 30 , , , cord-005453-4057qib7 8291 31 one one CD cord-005453-4057qib7 8291 32 of of IN cord-005453-4057qib7 8291 33 them -PRON- PRP cord-005453-4057qib7 8291 34 because because IN cord-005453-4057qib7 8291 35 of of IN cord-005453-4057qib7 8291 36 poor poor JJ cord-005453-4057qib7 8291 37 adherence adherence NN cord-005453-4057qib7 8291 38 to to IN cord-005453-4057qib7 8291 39 cART cART NNP cord-005453-4057qib7 8291 40 together together RB cord-005453-4057qib7 8291 41 with with IN cord-005453-4057qib7 8291 42 the the DT cord-005453-4057qib7 8291 43 accumulation accumulation NN cord-005453-4057qib7 8291 44 of of IN cord-005453-4057qib7 8291 45 multiple multiple JJ cord-005453-4057qib7 8291 46 resistance resistance NN cord-005453-4057qib7 8291 47 mutations mutation NNS cord-005453-4057qib7 8291 48 ; ; : cord-005453-4057qib7 8291 49 and and CC cord-005453-4057qib7 8291 50 the the DT cord-005453-4057qib7 8291 51 other other JJ cord-005453-4057qib7 8291 52 patient patient NN cord-005453-4057qib7 8291 53 had have VBD cord-005453-4057qib7 8291 54 detectable detectable JJ cord-005453-4057qib7 8291 55 HIV HIV NNP cord-005453-4057qib7 8291 56 RNA RNA NNP cord-005453-4057qib7 8291 57 at at IN cord-005453-4057qib7 8291 58 low low JJ cord-005453-4057qib7 8291 59 levels level NNS cord-005453-4057qib7 8291 60 ( ( -LRB- cord-005453-4057qib7 8291 61 < < XX cord-005453-4057qib7 8291 62 150 150 CD cord-005453-4057qib7 8291 63 copies copy NNS cord-005453-4057qib7 8291 64 / / SYM cord-005453-4057qib7 8291 65 mL ml NN cord-005453-4057qib7 8291 66 ) ) -RRB- cord-005453-4057qib7 8291 67 . . . cord-005453-4057qib7 8292 1 All all DT cord-005453-4057qib7 8292 2 patients patient NNS cord-005453-4057qib7 8292 3 received receive VBD cord-005453-4057qib7 8292 4 cART cart XX cord-005453-4057qib7 8292 5 throughout throughout IN cord-005453-4057qib7 8292 6 the the DT cord-005453-4057qib7 8292 7 transplant transplant NN cord-005453-4057qib7 8292 8 procedure procedure NN cord-005453-4057qib7 8292 9 , , , cord-005453-4057qib7 8292 10 being be VBG cord-005453-4057qib7 8292 11 temporally temporally RB cord-005453-4057qib7 8292 12 stopped stop VBN cord-005453-4057qib7 8292 13 in in IN cord-005453-4057qib7 8292 14 two two CD cord-005453-4057qib7 8292 15 patients patient NNS cord-005453-4057qib7 8292 16 due due JJ cord-005453-4057qib7 8292 17 to to IN cord-005453-4057qib7 8292 18 significant significant JJ cord-005453-4057qib7 8292 19 mucositis mucositis NN cord-005453-4057qib7 8292 20 . . . cord-005453-4057qib7 8293 1 After after IN cord-005453-4057qib7 8293 2 a a DT cord-005453-4057qib7 8293 3 median median JJ cord-005453-4057qib7 8293 4 follow follow NN cord-005453-4057qib7 8293 5 - - HYPH cord-005453-4057qib7 8293 6 up up NN cord-005453-4057qib7 8293 7 of of IN cord-005453-4057qib7 8293 8 65 65 CD cord-005453-4057qib7 8293 9 months month NNS cord-005453-4057qib7 8293 10 ( ( -LRB- cord-005453-4057qib7 8293 11 8 8 CD cord-005453-4057qib7 8293 12 - - SYM cord-005453-4057qib7 8293 13 112 112 CD cord-005453-4057qib7 8293 14 ) ) -RRB- cord-005453-4057qib7 8293 15 , , , cord-005453-4057qib7 8293 16 5-year 5-year CD cord-005453-4057qib7 8293 17 overall overall JJ cord-005453-4057qib7 8293 18 survival survival NN cord-005453-4057qib7 8293 19 ( ( -LRB- cord-005453-4057qib7 8293 20 OS OS NNP cord-005453-4057qib7 8293 21 ) ) -RRB- cord-005453-4057qib7 8293 22 and and CC cord-005453-4057qib7 8293 23 event event NN cord-005453-4057qib7 8293 24 - - HYPH cord-005453-4057qib7 8293 25 free free JJ cord-005453-4057qib7 8293 26 survival survival NN cord-005453-4057qib7 8293 27 ( ( -LRB- cord-005453-4057qib7 8293 28 EFS EFS NNP cord-005453-4057qib7 8293 29 ) ) -RRB- cord-005453-4057qib7 8293 30 were be VBD cord-005453-4057qib7 8293 31 46 46 CD cord-005453-4057qib7 8293 32 % % NN cord-005453-4057qib7 8293 33 . . . cord-005453-4057qib7 8294 1 NRM NRM NNP cord-005453-4057qib7 8294 2 was be VBD cord-005453-4057qib7 8294 3 14 14 CD cord-005453-4057qib7 8294 4 % % NN cord-005453-4057qib7 8294 5 at at IN cord-005453-4057qib7 8294 6 12 12 CD cord-005453-4057qib7 8294 7 months month NNS cord-005453-4057qib7 8294 8 and and CC cord-005453-4057qib7 8294 9 relapse relapse NN cord-005453-4057qib7 8294 10 was be VBD cord-005453-4057qib7 8294 11 24 24 CD cord-005453-4057qib7 8294 12 % % NN cord-005453-4057qib7 8294 13 at at IN cord-005453-4057qib7 8294 14 24 24 CD cord-005453-4057qib7 8294 15 months month NNS cord-005453-4057qib7 8294 16 . . . cord-005453-4057qib7 8295 1 Grade Grade NNP cord-005453-4057qib7 8295 2 II II NNP cord-005453-4057qib7 8295 3 - - HYPH cord-005453-4057qib7 8295 4 IV IV NNP cord-005453-4057qib7 8295 5 aGvHD agvhd NN cord-005453-4057qib7 8295 6 rate rate NN cord-005453-4057qib7 8295 7 was be VBD cord-005453-4057qib7 8295 8 40 40 CD cord-005453-4057qib7 8295 9 % % NN cord-005453-4057qib7 8295 10 , , , cord-005453-4057qib7 8295 11 and and CC cord-005453-4057qib7 8295 12 moderate moderate JJ cord-005453-4057qib7 8295 13 / / SYM cord-005453-4057qib7 8295 14 severe severe JJ cord-005453-4057qib7 8295 15 cGvHD cgvhd NN cord-005453-4057qib7 8295 16 rate rate NN cord-005453-4057qib7 8295 17 was be VBD cord-005453-4057qib7 8295 18 41 41 CD cord-005453-4057qib7 8295 19 % % NN cord-005453-4057qib7 8295 20 at at IN cord-005453-4057qib7 8295 21 24 24 CD cord-005453-4057qib7 8295 22 months month NNS cord-005453-4057qib7 8295 23 . . . cord-005453-4057qib7 8296 1 A a DT cord-005453-4057qib7 8296 2 significant significant JJ cord-005453-4057qib7 8296 3 proportion proportion NN cord-005453-4057qib7 8296 4 of of IN cord-005453-4057qib7 8296 5 patients patient NNS cord-005453-4057qib7 8296 6 ( ( -LRB- cord-005453-4057qib7 8296 7 68 68 CD cord-005453-4057qib7 8296 8 % % NN cord-005453-4057qib7 8296 9 ) ) -RRB- cord-005453-4057qib7 8296 10 showed show VBD cord-005453-4057qib7 8296 11 infectious infectious JJ cord-005453-4057qib7 8296 12 complications complication NNS cord-005453-4057qib7 8296 13 with with IN cord-005453-4057qib7 8296 14 viral viral JJ cord-005453-4057qib7 8296 15 infections infection NNS cord-005453-4057qib7 8296 16 as as IN cord-005453-4057qib7 8296 17 the the DT cord-005453-4057qib7 8296 18 most most RBS cord-005453-4057qib7 8296 19 frequent frequent JJ cord-005453-4057qib7 8296 20 cause cause NN cord-005453-4057qib7 8296 21 . . . cord-005453-4057qib7 8297 1 Two two CD cord-005453-4057qib7 8297 2 patients patient NNS cord-005453-4057qib7 8297 3 had have VBD cord-005453-4057qib7 8297 4 invasive invasive JJ cord-005453-4057qib7 8297 5 aspergillosis aspergillosis NN cord-005453-4057qib7 8297 6 and and CC cord-005453-4057qib7 8297 7 one one CD cord-005453-4057qib7 8297 8 patient patient NN cord-005453-4057qib7 8297 9 presented present VBN cord-005453-4057qib7 8297 10 disseminated disseminate VBN cord-005453-4057qib7 8297 11 tuberculosis tuberculosis NN cord-005453-4057qib7 8297 12 . . . cord-005453-4057qib7 8298 1 Causes cause NNS cord-005453-4057qib7 8298 2 of of IN cord-005453-4057qib7 8298 3 death death NN cord-005453-4057qib7 8298 4 included include VBD cord-005453-4057qib7 8298 5 infections infection NNS cord-005453-4057qib7 8298 6 ( ( -LRB- cord-005453-4057qib7 8298 7 50 50 CD cord-005453-4057qib7 8298 8 % % NN cord-005453-4057qib7 8298 9 ) ) -RRB- cord-005453-4057qib7 8298 10 , , , cord-005453-4057qib7 8298 11 relapse relapse NN cord-005453-4057qib7 8298 12 ( ( -LRB- cord-005453-4057qib7 8298 13 43 43 CD cord-005453-4057qib7 8298 14 % % NN cord-005453-4057qib7 8298 15 ) ) -RRB- cord-005453-4057qib7 8298 16 and and CC cord-005453-4057qib7 8298 17 toxicity toxicity NN cord-005453-4057qib7 8298 18 ( ( -LRB- cord-005453-4057qib7 8298 19 7 7 CD cord-005453-4057qib7 8298 20 % % NN cord-005453-4057qib7 8298 21 ) ) -RRB- cord-005453-4057qib7 8298 22 . . . cord-005453-4057qib7 8299 1 Among among IN cord-005453-4057qib7 8299 2 the the DT cord-005453-4057qib7 8299 3 6 6 CD cord-005453-4057qib7 8299 4 patients patient NNS cord-005453-4057qib7 8299 5 who who WP cord-005453-4057qib7 8299 6 died die VBD cord-005453-4057qib7 8299 7 due due IN cord-005453-4057qib7 8299 8 to to IN cord-005453-4057qib7 8299 9 infections infection NNS cord-005453-4057qib7 8299 10 , , , cord-005453-4057qib7 8299 11 3 3 CD cord-005453-4057qib7 8299 12 had have VBD cord-005453-4057qib7 8299 13 severe severe JJ cord-005453-4057qib7 8299 14 chronic chronic JJ cord-005453-4057qib7 8299 15 GVHD GVHD NNP cord-005453-4057qib7 8299 16 and and CC cord-005453-4057qib7 8299 17 were be VBD cord-005453-4057qib7 8299 18 under under IN cord-005453-4057qib7 8299 19 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 8299 20 therapy therapy NN cord-005453-4057qib7 8299 21 . . . cord-005453-4057qib7 8300 1 Two two CD cord-005453-4057qib7 8300 2 patients patient NNS cord-005453-4057qib7 8300 3 showed show VBD cord-005453-4057qib7 8300 4 severe severe JJ cord-005453-4057qib7 8300 5 toxicity toxicity NN cord-005453-4057qib7 8300 6 related relate VBN cord-005453-4057qib7 8300 7 to to IN cord-005453-4057qib7 8300 8 drug drug NN cord-005453-4057qib7 8300 9 interaction interaction NN cord-005453-4057qib7 8300 10 with with IN cord-005453-4057qib7 8300 11 anti anti JJ cord-005453-4057qib7 8300 12 - - JJ cord-005453-4057qib7 8300 13 retroviral retroviral JJ cord-005453-4057qib7 8300 14 therapy therapy NN cord-005453-4057qib7 8300 15 . . . cord-005453-4057qib7 8301 1 All all DT cord-005453-4057qib7 8301 2 survivors survivor NNS cord-005453-4057qib7 8301 3 except except IN cord-005453-4057qib7 8301 4 one one CD cord-005453-4057qib7 8301 5 showed show VBD cord-005453-4057qib7 8301 6 undetectable undetectable JJ cord-005453-4057qib7 8301 7 HIV HIV NNP cord-005453-4057qib7 8301 8 load load NN cord-005453-4057qib7 8301 9 at at IN cord-005453-4057qib7 8301 10 last last JJ cord-005453-4057qib7 8301 11 follow follow NN cord-005453-4057qib7 8301 12 - - HYPH cord-005453-4057qib7 8301 13 up up NN cord-005453-4057qib7 8301 14 after after IN cord-005453-4057qib7 8301 15 HSCT HSCT NNP cord-005453-4057qib7 8301 16 . . . cord-005453-4057qib7 8302 1 Conclusions conclusion NNS cord-005453-4057qib7 8302 2 : : : cord-005453-4057qib7 8303 1 Allogeneic Allogeneic NNP cord-005453-4057qib7 8303 2 HSCT HSCT NNP cord-005453-4057qib7 8303 3 is be VBZ cord-005453-4057qib7 8303 4 an an DT cord-005453-4057qib7 8303 5 effective effective JJ cord-005453-4057qib7 8303 6 therapy therapy NN cord-005453-4057qib7 8303 7 for for IN cord-005453-4057qib7 8303 8 high high JJ cord-005453-4057qib7 8303 9 - - HYPH cord-005453-4057qib7 8303 10 risk risk NN cord-005453-4057qib7 8303 11 hematological hematological JJ cord-005453-4057qib7 8303 12 malignancies malignancy NNS cord-005453-4057qib7 8303 13 in in IN cord-005453-4057qib7 8303 14 patients patient NNS cord-005453-4057qib7 8303 15 with with IN cord-005453-4057qib7 8303 16 HIV HIV NNP cord-005453-4057qib7 8303 17 infection infection NN cord-005453-4057qib7 8303 18 , , , cord-005453-4057qib7 8303 19 providing provide VBG cord-005453-4057qib7 8303 20 long long JJ cord-005453-4057qib7 8303 21 - - HYPH cord-005453-4057qib7 8303 22 term term NN cord-005453-4057qib7 8303 23 disease disease NN cord-005453-4057qib7 8303 24 free free JJ cord-005453-4057qib7 8303 25 survival survival NN cord-005453-4057qib7 8303 26 together together RB cord-005453-4057qib7 8303 27 to to IN cord-005453-4057qib7 8303 28 long long JJ cord-005453-4057qib7 8303 29 - - HYPH cord-005453-4057qib7 8303 30 term term NN cord-005453-4057qib7 8303 31 HIV HIV NNP cord-005453-4057qib7 8303 32 suppression suppression NN cord-005453-4057qib7 8303 33 with with IN cord-005453-4057qib7 8303 34 cART cART NNP cord-005453-4057qib7 8303 35 . . . cord-005453-4057qib7 8304 1 However however RB cord-005453-4057qib7 8304 2 , , , cord-005453-4057qib7 8304 3 drug drug NN cord-005453-4057qib7 8304 4 interactions interaction NNS cord-005453-4057qib7 8304 5 with with IN cord-005453-4057qib7 8304 6 anti anti JJ cord-005453-4057qib7 8304 7 - - JJ cord-005453-4057qib7 8304 8 retroviral retroviral JJ cord-005453-4057qib7 8304 9 agents agent NNS cord-005453-4057qib7 8304 10 , , , cord-005453-4057qib7 8304 11 occurrence occurrence NN cord-005453-4057qib7 8304 12 of of IN cord-005453-4057qib7 8304 13 GVHD GVHD NNP cord-005453-4057qib7 8304 14 , , , cord-005453-4057qib7 8304 15 and and CC cord-005453-4057qib7 8304 16 frequent frequent JJ cord-005453-4057qib7 8304 17 infectious infectious JJ cord-005453-4057qib7 8304 18 complications complication NNS cord-005453-4057qib7 8304 19 account account VBP cord-005453-4057qib7 8304 20 for for IN cord-005453-4057qib7 8304 21 a a DT cord-005453-4057qib7 8304 22 complex complex JJ cord-005453-4057qib7 8304 23 procedure procedure NN cord-005453-4057qib7 8304 24 in in IN cord-005453-4057qib7 8304 25 this this DT cord-005453-4057qib7 8304 26 population population NN cord-005453-4057qib7 8304 27 . . . cord-005453-4057qib7 8305 1 Selected select VBN cord-005453-4057qib7 8305 2 HIV HIV NNP cord-005453-4057qib7 8305 3 - - HYPH cord-005453-4057qib7 8305 4 infected infect VBN cord-005453-4057qib7 8305 5 patients patient NNS cord-005453-4057qib7 8305 6 with with IN cord-005453-4057qib7 8305 7 hematological hematological JJ cord-005453-4057qib7 8305 8 malignancies malignancy NNS cord-005453-4057qib7 8305 9 should should MD cord-005453-4057qib7 8305 10 be be VB cord-005453-4057qib7 8305 11 considered consider VBN cord-005453-4057qib7 8305 12 for for IN cord-005453-4057qib7 8305 13 allo allo NN cord-005453-4057qib7 8305 14 - - HYPH cord-005453-4057qib7 8305 15 HSCT HSCT NNP cord-005453-4057qib7 8305 16 when when WRB cord-005453-4057qib7 8305 17 indicated indicate VBD cord-005453-4057qib7 8305 18 , , , cord-005453-4057qib7 8305 19 in in IN cord-005453-4057qib7 8305 20 experienced experienced JJ cord-005453-4057qib7 8305 21 centers center NNS cord-005453-4057qib7 8305 22 , , , cord-005453-4057qib7 8305 23 with with IN cord-005453-4057qib7 8305 24 a a DT cord-005453-4057qib7 8305 25 multidisciplinary multidisciplinary JJ cord-005453-4057qib7 8305 26 care care NN cord-005453-4057qib7 8305 27 . . . cord-005453-4057qib7 8306 1 Disclosure disclosure NN cord-005453-4057qib7 8306 2 Background background NN cord-005453-4057qib7 8306 3 : : : cord-005453-4057qib7 8306 4 Primary primary JJ cord-005453-4057qib7 8306 5 immunodeficiencies immunodeficiency NNS cord-005453-4057qib7 8306 6 ( ( -LRB- cord-005453-4057qib7 8306 7 PID PID NNP cord-005453-4057qib7 8306 8 ) ) -RRB- cord-005453-4057qib7 8306 9 are be VBP cord-005453-4057qib7 8306 10 rare rare JJ cord-005453-4057qib7 8306 11 diseases disease NNS cord-005453-4057qib7 8306 12 often often RB cord-005453-4057qib7 8306 13 associated associate VBN cord-005453-4057qib7 8306 14 with with IN cord-005453-4057qib7 8306 15 genetic genetic JJ cord-005453-4057qib7 8306 16 defects defect NNS cord-005453-4057qib7 8306 17 in in IN cord-005453-4057qib7 8306 18 the the DT cord-005453-4057qib7 8306 19 immune immune JJ cord-005453-4057qib7 8306 20 system system NN cord-005453-4057qib7 8306 21 , , , cord-005453-4057qib7 8306 22 predisposing predispose VBG cord-005453-4057qib7 8306 23 individuals individual NNS cord-005453-4057qib7 8306 24 to to IN cord-005453-4057qib7 8306 25 recurrent recurrent JJ cord-005453-4057qib7 8306 26 infections infection NNS cord-005453-4057qib7 8306 27 and and CC cord-005453-4057qib7 8306 28 increased increase VBN cord-005453-4057qib7 8306 29 risk risk NN cord-005453-4057qib7 8306 30 of of IN cord-005453-4057qib7 8306 31 allergy allergy NN cord-005453-4057qib7 8306 32 , , , cord-005453-4057qib7 8306 33 autoimmunity autoimmunity NN cord-005453-4057qib7 8306 34 and and CC cord-005453-4057qib7 8306 35 malignancy malignancy NN cord-005453-4057qib7 8306 36 . . . cord-005453-4057qib7 8307 1 Allogeneic allogeneic IN cord-005453-4057qib7 8307 2 haematopoietic haematopoietic JJ cord-005453-4057qib7 8307 3 stem stem NN cord-005453-4057qib7 8307 4 cell cell NN cord-005453-4057qib7 8307 5 transplantation transplantation NN cord-005453-4057qib7 8307 6 ( ( -LRB- cord-005453-4057qib7 8307 7 HSCT HSCT NNP cord-005453-4057qib7 8307 8 ) ) -RRB- cord-005453-4057qib7 8307 9 has have VBZ cord-005453-4057qib7 8307 10 been be VBN cord-005453-4057qib7 8307 11 successfully successfully RB cord-005453-4057qib7 8307 12 used use VBN cord-005453-4057qib7 8307 13 as as IN cord-005453-4057qib7 8307 14 a a DT cord-005453-4057qib7 8307 15 curative curative JJ cord-005453-4057qib7 8307 16 therapy therapy NN cord-005453-4057qib7 8307 17 for for IN cord-005453-4057qib7 8307 18 most most JJS cord-005453-4057qib7 8307 19 severe severe JJ cord-005453-4057qib7 8307 20 forms form NNS cord-005453-4057qib7 8307 21 of of IN cord-005453-4057qib7 8307 22 PID PID NNP cord-005453-4057qib7 8307 23 . . . cord-005453-4057qib7 8308 1 Because because IN cord-005453-4057qib7 8308 2 PID PID NNP cord-005453-4057qib7 8308 3 is be VBZ cord-005453-4057qib7 8308 4 a a DT cord-005453-4057qib7 8308 5 genetic genetic JJ cord-005453-4057qib7 8308 6 disease disease NN cord-005453-4057qib7 8308 7 , , , cord-005453-4057qib7 8308 8 < < XX cord-005453-4057qib7 8308 9 25 25 CD cord-005453-4057qib7 8308 10 % % NN cord-005453-4057qib7 8308 11 of of IN cord-005453-4057qib7 8308 12 these these DT cord-005453-4057qib7 8308 13 children child NNS cord-005453-4057qib7 8308 14 will will MD cord-005453-4057qib7 8308 15 have have VB cord-005453-4057qib7 8308 16 a a DT cord-005453-4057qib7 8308 17 healthy healthy JJ cord-005453-4057qib7 8308 18 , , , cord-005453-4057qib7 8308 19 human human JJ cord-005453-4057qib7 8308 20 leukocyte leukocyte NN cord-005453-4057qib7 8308 21 antigen antigen NN cord-005453-4057qib7 8308 22 ( ( -LRB- cord-005453-4057qib7 8308 23 HLA HLA NNP cord-005453-4057qib7 8308 24 ) ) -RRB- cord-005453-4057qib7 8308 25 matched match VBD cord-005453-4057qib7 8308 26 sibling sibling NN cord-005453-4057qib7 8308 27 donor donor NN cord-005453-4057qib7 8308 28 available available JJ cord-005453-4057qib7 8308 29 , , , cord-005453-4057qib7 8308 30 and and CC cord-005453-4057qib7 8308 31 umbilical umbilical JJ cord-005453-4057qib7 8308 32 cord cord NN cord-005453-4057qib7 8308 33 blood blood NN cord-005453-4057qib7 8308 34 grafts graft NNS cord-005453-4057qib7 8308 35 from from IN cord-005453-4057qib7 8308 36 unrelated unrelated JJ cord-005453-4057qib7 8308 37 donors donor NNS cord-005453-4057qib7 8308 38 are be VBP cord-005453-4057qib7 8308 39 a a DT cord-005453-4057qib7 8308 40 suitable suitable JJ cord-005453-4057qib7 8308 41 alternative alternative JJ cord-005453-4057qib7 8308 42 cell cell NN cord-005453-4057qib7 8308 43 source source NN cord-005453-4057qib7 8308 44 . . . cord-005453-4057qib7 8309 1 We -PRON- PRP cord-005453-4057qib7 8309 2 report report VBP cord-005453-4057qib7 8309 3 the the DT cord-005453-4057qib7 8309 4 results result NNS cord-005453-4057qib7 8309 5 of of IN cord-005453-4057qib7 8309 6 umbilical umbilical JJ cord-005453-4057qib7 8309 7 cord cord NN cord-005453-4057qib7 8309 8 blood blood NN cord-005453-4057qib7 8309 9 transplantation transplantation NN cord-005453-4057qib7 8309 10 ( ( -LRB- cord-005453-4057qib7 8309 11 UCBT UCBT NNP cord-005453-4057qib7 8309 12 ) ) -RRB- cord-005453-4057qib7 8309 13 performed perform VBD cord-005453-4057qib7 8309 14 in in IN cord-005453-4057qib7 8309 15 112 112 CD cord-005453-4057qib7 8309 16 patients patient NNS cord-005453-4057qib7 8309 17 with with IN cord-005453-4057qib7 8309 18 PID PID NNP cord-005453-4057qib7 8309 19 between between IN cord-005453-4057qib7 8309 20 2014 2014 CD cord-005453-4057qib7 8309 21 and and CC cord-005453-4057qib7 8309 22 2018 2018 CD cord-005453-4057qib7 8309 23 at at IN cord-005453-4057qib7 8309 24 Children Children NNP cord-005453-4057qib7 8309 25 's 's POS cord-005453-4057qib7 8309 26 Hospital Hospital NNP cord-005453-4057qib7 8309 27 of of IN cord-005453-4057qib7 8309 28 Fudan Fudan NNP cord-005453-4057qib7 8309 29 University University NNP cord-005453-4057qib7 8309 30 in in IN cord-005453-4057qib7 8309 31 China China NNP cord-005453-4057qib7 8309 32 . . . cord-005453-4057qib7 8310 1 Methods method NNS cord-005453-4057qib7 8310 2 : : : cord-005453-4057qib7 8310 3 112 112 CD cord-005453-4057qib7 8310 4 patients patient NNS cord-005453-4057qib7 8310 5 included include VBD cord-005453-4057qib7 8310 6 chronic chronic JJ cord-005453-4057qib7 8310 7 granulomatous granulomatous JJ cord-005453-4057qib7 8310 8 disease disease NN cord-005453-4057qib7 8310 9 ( ( -LRB- cord-005453-4057qib7 8310 10 CGD CGD NNP cord-005453-4057qib7 8310 11 , , , cord-005453-4057qib7 8310 12 n=39 n=39 NNP cord-005453-4057qib7 8310 13 ) ) -RRB- cord-005453-4057qib7 8310 14 , , , cord-005453-4057qib7 8310 15 severe severe JJ cord-005453-4057qib7 8310 16 combined combine VBN cord-005453-4057qib7 8310 17 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8310 18 ( ( -LRB- cord-005453-4057qib7 8310 19 SCID SCID NNP cord-005453-4057qib7 8310 20 , , , cord-005453-4057qib7 8310 21 n=23 n=23 NNP cord-005453-4057qib7 8310 22 ) ) -RRB- cord-005453-4057qib7 8310 23 , , . cord-005453-4057qib7 8311 1 interleukin-10 interleukin-10 NNP cord-005453-4057qib7 8311 2 receptor receptor NN cord-005453-4057qib7 8311 3 - - : cord-005453-4057qib7 8311 4 a a DT cord-005453-4057qib7 8311 5 deficiency deficiency NN cord-005453-4057qib7 8311 6 ( ( -LRB- cord-005453-4057qib7 8311 7 IL-10RaD IL-10RaD NNP cord-005453-4057qib7 8311 8 , , , cord-005453-4057qib7 8311 9 n=27 n=27 NNP cord-005453-4057qib7 8311 10 ) ) -RRB- cord-005453-4057qib7 8312 1 , , , cord-005453-4057qib7 8312 2 Wiskott Wiskott NNP cord-005453-4057qib7 8312 3 - - HYPH cord-005453-4057qib7 8312 4 Aldrich Aldrich NNP cord-005453-4057qib7 8312 5 syndrome syndrome NN cord-005453-4057qib7 8312 6 ( ( -LRB- cord-005453-4057qib7 8312 7 WAS be VBD cord-005453-4057qib7 8312 8 , , , cord-005453-4057qib7 8312 9 n=7 n=7 NNS cord-005453-4057qib7 8312 10 ) ) -RRB- cord-005453-4057qib7 8312 11 , , , cord-005453-4057qib7 8312 12 leukocyte leukocyte NN cord-005453-4057qib7 8312 13 adhesion adhesion NN cord-005453-4057qib7 8312 14 deficiency deficiency NN cord-005453-4057qib7 8312 15 ( ( -LRB- cord-005453-4057qib7 8312 16 LAD lad NN cord-005453-4057qib7 8312 17 , , , cord-005453-4057qib7 8312 18 n=5 n=5 JJ cord-005453-4057qib7 8312 19 ) ) -RRB- cord-005453-4057qib7 8312 20 , , , cord-005453-4057qib7 8312 21 severe severe JJ cord-005453-4057qib7 8312 22 congenital congenital JJ cord-005453-4057qib7 8312 23 neutropaenia neutropaenia NNS cord-005453-4057qib7 8312 24 ( ( -LRB- cord-005453-4057qib7 8312 25 SCN SCN NNP cord-005453-4057qib7 8312 26 , , , cord-005453-4057qib7 8312 27 n=3 n=3 NN cord-005453-4057qib7 8312 28 ) ) -RRB- cord-005453-4057qib7 8312 29 and and CC cord-005453-4057qib7 8312 30 other other JJ cord-005453-4057qib7 8312 31 immunodeficiencies immunodeficiency NNS cord-005453-4057qib7 8312 32 ( ( -LRB- cord-005453-4057qib7 8312 33 n=8 n=8 NN cord-005453-4057qib7 8312 34 ) ) -RRB- cord-005453-4057qib7 8312 35 . . . cord-005453-4057qib7 8313 1 All all DT cord-005453-4057qib7 8313 2 patients patient NNS cord-005453-4057qib7 8313 3 were be VBD cord-005453-4057qib7 8313 4 assessed assess VBN cord-005453-4057qib7 8313 5 by by IN cord-005453-4057qib7 8313 6 clinical clinical JJ cord-005453-4057qib7 8313 7 immunologist immunologist NN cord-005453-4057qib7 8313 8 to to TO cord-005453-4057qib7 8313 9 confirm confirm VB cord-005453-4057qib7 8313 10 clinical clinical JJ cord-005453-4057qib7 8313 11 phenotype phenotype NN cord-005453-4057qib7 8313 12 and and CC cord-005453-4057qib7 8313 13 genetic genetic JJ cord-005453-4057qib7 8313 14 diagnosis diagnosis NN cord-005453-4057qib7 8313 15 . . . cord-005453-4057qib7 8314 1 Median median JJ cord-005453-4057qib7 8314 2 age age NN cord-005453-4057qib7 8314 3 of of IN cord-005453-4057qib7 8314 4 112 112 CD cord-005453-4057qib7 8314 5 patients patient NNS cord-005453-4057qib7 8314 6 was be VBD cord-005453-4057qib7 8314 7 13 13 CD cord-005453-4057qib7 8314 8 months month NNS cord-005453-4057qib7 8314 9 ( ( -LRB- cord-005453-4057qib7 8314 10 range range NN cord-005453-4057qib7 8314 11 , , , cord-005453-4057qib7 8314 12 2 2 CD cord-005453-4057qib7 8314 13 to to TO cord-005453-4057qib7 8314 14 144 144 CD cord-005453-4057qib7 8314 15 months month NNS cord-005453-4057qib7 8314 16 ) ) -RRB- cord-005453-4057qib7 8314 17 , , , cord-005453-4057qib7 8314 18 and and CC cord-005453-4057qib7 8314 19 median median JJ cord-005453-4057qib7 8314 20 body body NN cord-005453-4057qib7 8314 21 weight weight NN cord-005453-4057qib7 8314 22 was be VBD cord-005453-4057qib7 8314 23 8.75 8.75 CD cord-005453-4057qib7 8314 24 kg kg NN cord-005453-4057qib7 8314 25 ( ( -LRB- cord-005453-4057qib7 8314 26 range range NN cord-005453-4057qib7 8314 27 , , , cord-005453-4057qib7 8314 28 3.2 3.2 CD cord-005453-4057qib7 8314 29 to to IN cord-005453-4057qib7 8314 30 36 36 CD cord-005453-4057qib7 8314 31 kg kg NNS cord-005453-4057qib7 8314 32 ) ) -RRB- cord-005453-4057qib7 8314 33 . . . cord-005453-4057qib7 8315 1 All all DT cord-005453-4057qib7 8315 2 patients patient NNS cord-005453-4057qib7 8315 3 received receive VBD cord-005453-4057qib7 8315 4 a a DT cord-005453-4057qib7 8315 5 ≤3/10 ≤3/10 NNP cord-005453-4057qib7 8315 6 HLA HLA NNP cord-005453-4057qib7 8315 7 alleles allele NNS cord-005453-4057qib7 8315 8 - - HYPH cord-005453-4057qib7 8315 9 mismatched mismatch VBN cord-005453-4057qib7 8315 10 cord cord NN cord-005453-4057qib7 8315 11 blood blood NN cord-005453-4057qib7 8315 12 unit unit NN cord-005453-4057qib7 8315 13 , , , cord-005453-4057qib7 8315 14 16 16 CD cord-005453-4057qib7 8315 15 were be VBD cord-005453-4057qib7 8315 16 HLA HLA NNP cord-005453-4057qib7 8315 17 fully fully RB cord-005453-4057qib7 8315 18 matched match VBN cord-005453-4057qib7 8315 19 , , , cord-005453-4057qib7 8315 20 28 28 CD cord-005453-4057qib7 8315 21 were be VBD cord-005453-4057qib7 8315 22 9/10 9/10 CD cord-005453-4057qib7 8315 23 matched match VBN cord-005453-4057qib7 8315 24 , , , cord-005453-4057qib7 8315 25 49 49 CD cord-005453-4057qib7 8315 26 were be VBD cord-005453-4057qib7 8315 27 8/10 8/10 CD cord-005453-4057qib7 8315 28 matched match VBN cord-005453-4057qib7 8315 29 and and CC cord-005453-4057qib7 8315 30 19 19 CD cord-005453-4057qib7 8315 31 were be VBD cord-005453-4057qib7 8315 32 7/10 7/10 CD cord-005453-4057qib7 8315 33 matched match VBN cord-005453-4057qib7 8315 34 . . . cord-005453-4057qib7 8316 1 Median median JJ cord-005453-4057qib7 8316 2 nucleated nucleated JJ cord-005453-4057qib7 8316 3 cells cell NNS cord-005453-4057qib7 8316 4 of of IN cord-005453-4057qib7 8316 5 the the DT cord-005453-4057qib7 8316 6 cord cord NN cord-005453-4057qib7 8316 7 blood blood NN cord-005453-4057qib7 8316 8 were be VBD cord-005453-4057qib7 8316 9 14.23x10 14.23x10 CD cord-005453-4057qib7 8316 10 7 7 CD cord-005453-4057qib7 8317 1 /kg /kg . cord-005453-4057qib7 8318 1 ( ( -LRB- cord-005453-4057qib7 8318 2 range range NN cord-005453-4057qib7 8318 3 , , , cord-005453-4057qib7 8318 4 3.55 3.55 CD cord-005453-4057qib7 8318 5 to to IN cord-005453-4057qib7 8318 6 51.5 51.5 CD cord-005453-4057qib7 8318 7 x10 x10 CD cord-005453-4057qib7 8318 8 7 7 CD cord-005453-4057qib7 8318 9 /kg /kg . cord-005453-4057qib7 8318 10 ) ) -RRB- cord-005453-4057qib7 8318 11 , , , cord-005453-4057qib7 8318 12 and and CC cord-005453-4057qib7 8318 13 median median JJ cord-005453-4057qib7 8318 14 CD34 CD34 NNP cord-005453-4057qib7 8318 15 + + CC cord-005453-4057qib7 8318 16 cells cell NNS cord-005453-4057qib7 8318 17 were be VBD cord-005453-4057qib7 8318 18 3.86 3.86 CD cord-005453-4057qib7 8318 19 x10 x10 CD cord-005453-4057qib7 8318 20 5 5 CD cord-005453-4057qib7 8319 1 /kg /kg . cord-005453-4057qib7 8320 1 ( ( -LRB- cord-005453-4057qib7 8320 2 range range NN cord-005453-4057qib7 8320 3 , , , cord-005453-4057qib7 8320 4 0.73 0.73 CD cord-005453-4057qib7 8320 5 to to IN cord-005453-4057qib7 8320 6 30.27 30.27 CD cord-005453-4057qib7 8320 7 x10 x10 CD cord-005453-4057qib7 8320 8 5 5 CD cord-005453-4057qib7 8320 9 /kg /kg NFP cord-005453-4057qib7 8320 10 ) ) -RRB- cord-005453-4057qib7 8320 11 . . . cord-005453-4057qib7 8321 1 Results result NNS cord-005453-4057qib7 8321 2 : : : cord-005453-4057qib7 8322 1 Median median JJ cord-005453-4057qib7 8322 2 follow follow NN cord-005453-4057qib7 8322 3 - - HYPH cord-005453-4057qib7 8322 4 up up RP cord-005453-4057qib7 8322 5 time time NN cord-005453-4057qib7 8322 6 was be VBD cord-005453-4057qib7 8322 7 13 13 CD cord-005453-4057qib7 8322 8 months month NNS cord-005453-4057qib7 8322 9 ( ( -LRB- cord-005453-4057qib7 8322 10 range range NN cord-005453-4057qib7 8322 11 , , , cord-005453-4057qib7 8322 12 1 1 CD cord-005453-4057qib7 8322 13 to to TO cord-005453-4057qib7 8322 14 57 57 CD cord-005453-4057qib7 8322 15 months month NNS cord-005453-4057qib7 8322 16 ) ) -RRB- cord-005453-4057qib7 8322 17 , , , cord-005453-4057qib7 8322 18 the the DT cord-005453-4057qib7 8322 19 overall overall JJ cord-005453-4057qib7 8322 20 survival survival NN cord-005453-4057qib7 8322 21 rate rate NN cord-005453-4057qib7 8322 22 at at IN cord-005453-4057qib7 8322 23 1 1 CD cord-005453-4057qib7 8322 24 year year NN cord-005453-4057qib7 8322 25 for for IN cord-005453-4057qib7 8322 26 all all DT cord-005453-4057qib7 8322 27 patients patient NNS cord-005453-4057qib7 8322 28 was be VBD cord-005453-4057qib7 8322 29 74.6 74.6 CD cord-005453-4057qib7 8322 30 % % NN cord-005453-4057qib7 8322 31 , , , cord-005453-4057qib7 8322 32 and and CC cord-005453-4057qib7 8322 33 was be VBD cord-005453-4057qib7 8322 34 83.7 83.7 CD cord-005453-4057qib7 8322 35 % % NN cord-005453-4057qib7 8322 36 , , , cord-005453-4057qib7 8322 37 78.3 78.3 CD cord-005453-4057qib7 8322 38 % % NN cord-005453-4057qib7 8322 39 and and CC cord-005453-4057qib7 8322 40 60 60 CD cord-005453-4057qib7 8322 41 % % NN cord-005453-4057qib7 8322 42 for for IN cord-005453-4057qib7 8322 43 CGD CGD NNP cord-005453-4057qib7 8322 44 , , , cord-005453-4057qib7 8322 45 SCID SCID NNP cord-005453-4057qib7 8322 46 and and CC cord-005453-4057qib7 8322 47 IL-10RaD IL-10RaD NNP cord-005453-4057qib7 8322 48 , , , cord-005453-4057qib7 8322 49 respectively respectively RB cord-005453-4057qib7 8322 50 . . . cord-005453-4057qib7 8323 1 27 27 CD cord-005453-4057qib7 8323 2 patients patient NNS cord-005453-4057qib7 8323 3 died die VBD cord-005453-4057qib7 8323 4 , , , cord-005453-4057qib7 8323 5 Most Most JJS cord-005453-4057qib7 8323 6 deaths death NNS cord-005453-4057qib7 8323 7 ( ( -LRB- cord-005453-4057qib7 8323 8 19/27 19/27 CD cord-005453-4057qib7 8323 9 , , , cord-005453-4057qib7 8323 10 70.4 70.4 CD cord-005453-4057qib7 8323 11 % % NN cord-005453-4057qib7 8323 12 ) ) -RRB- cord-005453-4057qib7 8323 13 occurred occur VBD cord-005453-4057qib7 8323 14 in in IN cord-005453-4057qib7 8323 15 +100 +100 NNP cord-005453-4057qib7 8323 16 days day NNS cord-005453-4057qib7 8323 17 after after IN cord-005453-4057qib7 8323 18 transplantation transplantation NN cord-005453-4057qib7 8323 19 , , , cord-005453-4057qib7 8323 20 the the DT cord-005453-4057qib7 8323 21 main main JJ cord-005453-4057qib7 8323 22 cause cause NN cord-005453-4057qib7 8323 23 of of IN cord-005453-4057qib7 8323 24 death death NN cord-005453-4057qib7 8323 25 was be VBD cord-005453-4057qib7 8323 26 infection infection NN cord-005453-4057qib7 8323 27 ( ( -LRB- cord-005453-4057qib7 8323 28 24/ 24/ CD cord-005453-4057qib7 8323 29 27 27 CD cord-005453-4057qib7 8323 30 , , , cord-005453-4057qib7 8323 31 88.9 88.9 CD cord-005453-4057qib7 8323 32 % % NN cord-005453-4057qib7 8323 33 ) ) -RRB- cord-005453-4057qib7 8323 34 . . . cord-005453-4057qib7 8324 1 87/112 87/112 CD cord-005453-4057qib7 8324 2 ( ( -LRB- cord-005453-4057qib7 8324 3 77.7 77.7 CD cord-005453-4057qib7 8324 4 % % NN cord-005453-4057qib7 8324 5 ) ) -RRB- cord-005453-4057qib7 8325 1 patients patient NNS cord-005453-4057qib7 8325 2 engrafted engraft VBN cord-005453-4057qib7 8325 3 , , , cord-005453-4057qib7 8325 4 median median JJ cord-005453-4057qib7 8325 5 time time NN cord-005453-4057qib7 8325 6 of of IN cord-005453-4057qib7 8325 7 neutrophil neutrophil NN cord-005453-4057qib7 8325 8 engraftment engraftment NN cord-005453-4057qib7 8325 9 was be VBD cord-005453-4057qib7 8325 10 24 24 CD cord-005453-4057qib7 8325 11 days day NNS cord-005453-4057qib7 8325 12 ( ( -LRB- cord-005453-4057qib7 8325 13 range range NN cord-005453-4057qib7 8325 14 , , , cord-005453-4057qib7 8325 15 11 11 CD cord-005453-4057qib7 8325 16 to to TO cord-005453-4057qib7 8325 17 60 60 CD cord-005453-4057qib7 8325 18 d d NN cord-005453-4057qib7 8325 19 ) ) -RRB- cord-005453-4057qib7 8325 20 , , , cord-005453-4057qib7 8325 21 and and CC cord-005453-4057qib7 8325 22 median median JJ cord-005453-4057qib7 8325 23 time time NN cord-005453-4057qib7 8325 24 of of IN cord-005453-4057qib7 8325 25 platelet platelet NN cord-005453-4057qib7 8325 26 engraftment engraftment NN cord-005453-4057qib7 8325 27 was be VBD cord-005453-4057qib7 8325 28 36 36 CD cord-005453-4057qib7 8325 29 days day NNS cord-005453-4057qib7 8325 30 ( ( -LRB- cord-005453-4057qib7 8325 31 range range NN cord-005453-4057qib7 8325 32 , , , cord-005453-4057qib7 8325 33 9 9 CD cord-005453-4057qib7 8325 34 to to TO cord-005453-4057qib7 8325 35 59 59 CD cord-005453-4057qib7 8325 36 d d NN cord-005453-4057qib7 8325 37 ) ) -RRB- cord-005453-4057qib7 8325 38 . . . cord-005453-4057qib7 8326 1 The the DT cord-005453-4057qib7 8326 2 cumulative cumulative JJ cord-005453-4057qib7 8326 3 incidence incidence NN cord-005453-4057qib7 8326 4 of of IN cord-005453-4057qib7 8326 5 grade grade NN cord-005453-4057qib7 8326 6 3 3 CD cord-005453-4057qib7 8326 7 - - SYM cord-005453-4057qib7 8326 8 4 4 CD cord-005453-4057qib7 8326 9 acute acute JJ cord-005453-4057qib7 8326 10 GVHD GVHD NNP cord-005453-4057qib7 8326 11 was be VBD cord-005453-4057qib7 8326 12 8.9 8.9 CD cord-005453-4057qib7 8326 13 % % NN cord-005453-4057qib7 8326 14 , , , cord-005453-4057qib7 8326 15 and and CC cord-005453-4057qib7 8326 16 that that DT cord-005453-4057qib7 8326 17 of of IN cord-005453-4057qib7 8326 18 chronic chronic JJ cord-005453-4057qib7 8326 19 GVHD GVHD NNP cord-005453-4057qib7 8326 20 was be VBD cord-005453-4057qib7 8326 21 10.7 10.7 CD cord-005453-4057qib7 8326 22 % % NN cord-005453-4057qib7 8326 23 . . . cord-005453-4057qib7 8327 1 Conclusions conclusion NNS cord-005453-4057qib7 8327 2 : : : cord-005453-4057qib7 8328 1 Unrelated unrelated JJ cord-005453-4057qib7 8328 2 UCBT UCBT NNS cord-005453-4057qib7 8328 3 should should MD cord-005453-4057qib7 8328 4 be be VB cord-005453-4057qib7 8328 5 considered consider VBN cord-005453-4057qib7 8328 6 for for IN cord-005453-4057qib7 8328 7 PID PID NNP cord-005453-4057qib7 8328 8 patients patient NNS cord-005453-4057qib7 8328 9 without without IN cord-005453-4057qib7 8328 10 an an DT cord-005453-4057qib7 8328 11 HLA HLA NNP cord-005453-4057qib7 8328 12 -matched -matched JJ cord-005453-4057qib7 8328 13 sibling sibling NN cord-005453-4057qib7 8328 14 donor donor NN cord-005453-4057qib7 8328 15 . . . cord-005453-4057qib7 8329 1 Effective effective JJ cord-005453-4057qib7 8329 2 control control NN cord-005453-4057qib7 8329 3 of of IN cord-005453-4057qib7 8329 4 infection infection NN cord-005453-4057qib7 8329 5 before before RB cord-005453-4057qib7 8329 6 and and CC cord-005453-4057qib7 8330 1 after after IN cord-005453-4057qib7 8330 2 transplantation transplantation NN cord-005453-4057qib7 8330 3 is be VBZ cord-005453-4057qib7 8330 4 important important JJ cord-005453-4057qib7 8330 5 for for IN cord-005453-4057qib7 8330 6 improving improve VBG cord-005453-4057qib7 8330 7 survival survival NN cord-005453-4057qib7 8330 8 . . . cord-005453-4057qib7 8331 1 Disclosure disclosure NN cord-005453-4057qib7 8331 2 Background background NN cord-005453-4057qib7 8331 3 : : : cord-005453-4057qib7 8331 4 Dedicator Dedicator NNP cord-005453-4057qib7 8331 5 of of IN cord-005453-4057qib7 8331 6 cytokinesis cytokinesis NN cord-005453-4057qib7 8332 1 ( ( -LRB- cord-005453-4057qib7 8332 2 Dock Dock NNP cord-005453-4057qib7 8332 3 8) 8) NN cord-005453-4057qib7 8332 4 deficiency deficiency NN cord-005453-4057qib7 8332 5 causes cause VBZ cord-005453-4057qib7 8332 6 a a DT cord-005453-4057qib7 8332 7 combined combine VBN cord-005453-4057qib7 8332 8 immune immune JJ cord-005453-4057qib7 8332 9 deficiency deficiency NN cord-005453-4057qib7 8332 10 characterised characterise VBN cord-005453-4057qib7 8332 11 by by IN cord-005453-4057qib7 8332 12 recurrent recurrent JJ cord-005453-4057qib7 8332 13 bacterial bacterial JJ cord-005453-4057qib7 8332 14 infections infection NNS cord-005453-4057qib7 8332 15 , , , cord-005453-4057qib7 8332 16 susceptibility susceptibility NN cord-005453-4057qib7 8332 17 to to IN cord-005453-4057qib7 8332 18 viral viral JJ cord-005453-4057qib7 8332 19 infection infection NN cord-005453-4057qib7 8332 20 , , , cord-005453-4057qib7 8332 21 eczema eczema NN cord-005453-4057qib7 8332 22 , , , cord-005453-4057qib7 8332 23 food food NN cord-005453-4057qib7 8332 24 allergies allergy NNS cord-005453-4057qib7 8332 25 , , , cord-005453-4057qib7 8332 26 vasculitis vasculitis NN cord-005453-4057qib7 8332 27 and and CC cord-005453-4057qib7 8332 28 increased increase VBN cord-005453-4057qib7 8332 29 risk risk NN cord-005453-4057qib7 8332 30 of of IN cord-005453-4057qib7 8332 31 malignancy malignancy NN cord-005453-4057qib7 8332 32 . . . cord-005453-4057qib7 8333 1 Due due IN cord-005453-4057qib7 8333 2 to to IN cord-005453-4057qib7 8333 3 the the DT cord-005453-4057qib7 8333 4 high high JJ cord-005453-4057qib7 8333 5 morbidity morbidity NN cord-005453-4057qib7 8333 6 and and CC cord-005453-4057qib7 8333 7 mortality mortality NN cord-005453-4057qib7 8333 8 of of IN cord-005453-4057qib7 8333 9 the the DT cord-005453-4057qib7 8333 10 disease disease NN cord-005453-4057qib7 8333 11 HSCT HSCT NNP cord-005453-4057qib7 8333 12 has have VBZ cord-005453-4057qib7 8333 13 been be VBN cord-005453-4057qib7 8333 14 increasingly increasingly RB cord-005453-4057qib7 8333 15 offered offer VBN cord-005453-4057qib7 8333 16 to to IN cord-005453-4057qib7 8333 17 patients patient NNS cord-005453-4057qib7 8333 18 as as IN cord-005453-4057qib7 8333 19 a a DT cord-005453-4057qib7 8333 20 potentially potentially RB cord-005453-4057qib7 8333 21 curative curative JJ cord-005453-4057qib7 8333 22 therapy therapy NN cord-005453-4057qib7 8333 23 1 1 CD cord-005453-4057qib7 8333 24 . . . cord-005453-4057qib7 8334 1 Methods method NNS cord-005453-4057qib7 8334 2 : : : cord-005453-4057qib7 8334 3 We -PRON- PRP cord-005453-4057qib7 8334 4 retrospectively retrospectively RB cord-005453-4057qib7 8334 5 reviewed review VBD cord-005453-4057qib7 8334 6 the the DT cord-005453-4057qib7 8334 7 outcomes outcome NNS cord-005453-4057qib7 8334 8 of of IN cord-005453-4057qib7 8334 9 HSCT HSCT NNP cord-005453-4057qib7 8334 10 for for IN cord-005453-4057qib7 8334 11 patients patient NNS cord-005453-4057qib7 8334 12 with with IN cord-005453-4057qib7 8334 13 Dock Dock NNP cord-005453-4057qib7 8334 14 8 8 CD cord-005453-4057qib7 8334 15 deficiency deficiency NN cord-005453-4057qib7 8334 16 at at IN cord-005453-4057qib7 8334 17 Great Great NNP cord-005453-4057qib7 8334 18 North North NNP cord-005453-4057qib7 8334 19 Children Children NNP cord-005453-4057qib7 8334 20 's 's POS cord-005453-4057qib7 8334 21 hospital hospital NN cord-005453-4057qib7 8334 22 Newcastle Newcastle NNP cord-005453-4057qib7 8334 23 upon upon IN cord-005453-4057qib7 8334 24 Tyne Tyne NNP cord-005453-4057qib7 8334 25 between between IN cord-005453-4057qib7 8334 26 2011 2011 CD cord-005453-4057qib7 8334 27 and and CC cord-005453-4057qib7 8334 28 2018 2018 CD cord-005453-4057qib7 8334 29 ( ( -LRB- cord-005453-4057qib7 8334 30 5 5 CD cord-005453-4057qib7 8334 31 in in IN cord-005453-4057qib7 8334 32 published publish VBN cord-005453-4057qib7 8334 33 reference reference NN cord-005453-4057qib7 8334 34 ) ) -RRB- cord-005453-4057qib7 8334 35 . . . cord-005453-4057qib7 8335 1 Results result NNS cord-005453-4057qib7 8335 2 : : : cord-005453-4057qib7 8336 1 Ten ten CD cord-005453-4057qib7 8336 2 patients patient NNS cord-005453-4057qib7 8336 3 with with IN cord-005453-4057qib7 8336 4 Dock Dock NNP cord-005453-4057qib7 8336 5 8 8 CD cord-005453-4057qib7 8336 6 deficiency deficiency NN cord-005453-4057qib7 8336 7 were be VBD cord-005453-4057qib7 8336 8 treated treat VBN cord-005453-4057qib7 8336 9 with with IN cord-005453-4057qib7 8336 10 HSCT HSCT NNP cord-005453-4057qib7 8336 11 ( ( -LRB- cord-005453-4057qib7 8336 12 Median median JJ cord-005453-4057qib7 8336 13 age age NN cord-005453-4057qib7 8336 14 7.5y 7.5y CD cord-005453-4057qib7 8336 15 range range NN cord-005453-4057qib7 8336 16 4.5 4.5 CD cord-005453-4057qib7 8336 17 - - HYPH cord-005453-4057qib7 8336 18 16.8y 16.8y CD cord-005453-4057qib7 8336 19 ) ) -RRB- cord-005453-4057qib7 8336 20 . . . cord-005453-4057qib7 8337 1 Median median JJ cord-005453-4057qib7 8337 2 duration duration NN cord-005453-4057qib7 8337 3 of of IN cord-005453-4057qib7 8337 4 follow follow NN cord-005453-4057qib7 8337 5 up up RP cord-005453-4057qib7 8337 6 was be VBD cord-005453-4057qib7 8337 7 4.5years 4.5years CD cord-005453-4057qib7 8337 8 ( ( -LRB- cord-005453-4057qib7 8337 9 range range VB cord-005453-4057qib7 8337 10 1.3 1.3 CD cord-005453-4057qib7 8337 11 - - SYM cord-005453-4057qib7 8337 12 6.5y 6.5y CD cord-005453-4057qib7 8337 13 ) ) -RRB- cord-005453-4057qib7 8337 14 . . . cord-005453-4057qib7 8338 1 There there EX cord-005453-4057qib7 8338 2 were be VBD cord-005453-4057qib7 8338 3 a a DT cord-005453-4057qib7 8338 4 range range NN cord-005453-4057qib7 8338 5 of of IN cord-005453-4057qib7 8338 6 donor donor NN cord-005453-4057qib7 8338 7 sources source NNS cord-005453-4057qib7 8338 8 ( ( -LRB- cord-005453-4057qib7 8338 9 3 3 CD cord-005453-4057qib7 8338 10 MSD MSD NNP cord-005453-4057qib7 8338 11 , , , cord-005453-4057qib7 8338 12 3 3 CD cord-005453-4057qib7 8338 13 MUD mud NN cord-005453-4057qib7 8338 14 and and CC cord-005453-4057qib7 8338 15 4 4 CD cord-005453-4057qib7 8338 16 TCR TCR NNP cord-005453-4057qib7 8338 17 ab ab NNP cord-005453-4057qib7 8338 18 / / SYM cord-005453-4057qib7 8338 19 CD19 CD19 NNP cord-005453-4057qib7 8338 20 + + CC cord-005453-4057qib7 8338 21 depleted deplete VBN cord-005453-4057qib7 8338 22 haploidentical haploidentical JJ cord-005453-4057qib7 8338 23 ) ) -RRB- cord-005453-4057qib7 8338 24 , , , cord-005453-4057qib7 8338 25 conditioning conditioning NN cord-005453-4057qib7 8338 26 regimens regimen NNS cord-005453-4057qib7 8338 27 ( ( -LRB- cord-005453-4057qib7 8338 28 6 6 CD cord-005453-4057qib7 8338 29 Treo Treo NNP cord-005453-4057qib7 8338 30 - - HYPH cord-005453-4057qib7 8338 31 Flu Flu NNP cord-005453-4057qib7 8338 32 , , , cord-005453-4057qib7 8338 33 4 4 CD cord-005453-4057qib7 8338 34 Treo Treo NNP cord-005453-4057qib7 8338 35 - - HYPH cord-005453-4057qib7 8338 36 Flu Flu NNP cord-005453-4057qib7 8338 37 - - HYPH cord-005453-4057qib7 8338 38 Thiotepa Thiotepa NNP cord-005453-4057qib7 8338 39 ) ) -RRB- cord-005453-4057qib7 8338 40 and and CC cord-005453-4057qib7 8338 41 serotherapy serotherapy NNP cord-005453-4057qib7 8338 42 ( ( -LRB- cord-005453-4057qib7 8338 43 5 5 CD cord-005453-4057qib7 8338 44 alemtuzumab alemtuzumab NNS cord-005453-4057qib7 8338 45 , , , cord-005453-4057qib7 8338 46 3 3 CD cord-005453-4057qib7 8338 47 ATG+Rituximab atg+rituximab NN cord-005453-4057qib7 8338 48 , , , cord-005453-4057qib7 8338 49 2 2 CD cord-005453-4057qib7 8338 50 none none NN cord-005453-4057qib7 8338 51 ) ) -RRB- cord-005453-4057qib7 8338 52 . . . cord-005453-4057qib7 8339 1 One one CD cord-005453-4057qib7 8339 2 patient patient NN cord-005453-4057qib7 8339 3 who who WP cord-005453-4057qib7 8339 4 received receive VBD cord-005453-4057qib7 8339 5 a a DT cord-005453-4057qib7 8339 6 CD3 cd3 NN cord-005453-4057qib7 8339 7 + + CC cord-005453-4057qib7 8340 1 TCR TCR NNP cord-005453-4057qib7 8340 2 alpha alpha NN cord-005453-4057qib7 8340 3 beta beta NN cord-005453-4057qib7 8340 4 / / SYM cord-005453-4057qib7 8340 5 CD19 CD19 NNP cord-005453-4057qib7 8341 1 + + CC cord-005453-4057qib7 8341 2 depleted deplete VBN cord-005453-4057qib7 8341 3 haploidentical haploidentical JJ cord-005453-4057qib7 8341 4 transplant transplant NN cord-005453-4057qib7 8341 5 received receive VBD cord-005453-4057qib7 8341 6 add add NN cord-005453-4057qib7 8341 7 back back RP cord-005453-4057qib7 8341 8 T t NN cord-005453-4057qib7 8341 9 - - HYPH cord-005453-4057qib7 8341 10 cells cell NNS cord-005453-4057qib7 8341 11 with with IN cord-005453-4057qib7 8341 12 caspacide caspacide NN cord-005453-4057qib7 8341 13 molecular molecular JJ cord-005453-4057qib7 8341 14 safety safety NN cord-005453-4057qib7 8341 15 switch switch NN cord-005453-4057qib7 8341 16 ( ( -LRB- cord-005453-4057qib7 8341 17 Bellicum Bellicum NNP cord-005453-4057qib7 8341 18 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 8341 19 ) ) -RRB- cord-005453-4057qib7 8341 20 . . . cord-005453-4057qib7 8342 1 Skin skin NN cord-005453-4057qib7 8342 2 only only RB cord-005453-4057qib7 8342 3 aGVHD aGVHD NNP cord-005453-4057qib7 8342 4 occurred occur VBD cord-005453-4057qib7 8342 5 in in IN cord-005453-4057qib7 8342 6 3/10 3/10 CD cord-005453-4057qib7 8342 7 patients patient NNS cord-005453-4057qib7 8342 8 ( ( -LRB- cord-005453-4057qib7 8342 9 1x 1x CD cord-005453-4057qib7 8342 10 stage stage NN cord-005453-4057qib7 8342 11 1 1 CD cord-005453-4057qib7 8342 12 , , , cord-005453-4057qib7 8342 13 2x 2x CD cord-005453-4057qib7 8342 14 stage stage NN cord-005453-4057qib7 8342 15 3 3 CD cord-005453-4057qib7 8342 16 ) ) -RRB- cord-005453-4057qib7 8342 17 . . . cord-005453-4057qib7 8343 1 No no DT cord-005453-4057qib7 8343 2 patients patient NNS cord-005453-4057qib7 8343 3 had have VBD cord-005453-4057qib7 8343 4 cGVHD cGVHD NNP cord-005453-4057qib7 8343 5 . . . cord-005453-4057qib7 8344 1 Overall overall JJ cord-005453-4057qib7 8344 2 survival survival NN cord-005453-4057qib7 8344 3 was be VBD cord-005453-4057qib7 8344 4 60 60 CD cord-005453-4057qib7 8344 5 % % NN cord-005453-4057qib7 8344 6 ( ( -LRB- cord-005453-4057qib7 8344 7 6/10 6/10 CD cord-005453-4057qib7 8344 8 ) ) -RRB- cord-005453-4057qib7 8344 9 . . . cord-005453-4057qib7 8345 1 Survival survival NN cord-005453-4057qib7 8345 2 was be VBD cord-005453-4057qib7 8345 3 comparable comparable JJ cord-005453-4057qib7 8345 4 regardless regardless RB cord-005453-4057qib7 8345 5 of of IN cord-005453-4057qib7 8345 6 donor donor NN cord-005453-4057qib7 8345 7 source source NN cord-005453-4057qib7 8345 8 . . . cord-005453-4057qib7 8346 1 All all DT cord-005453-4057qib7 8346 2 deaths death NNS cord-005453-4057qib7 8346 3 occurred occur VBD cord-005453-4057qib7 8346 4 within within IN cord-005453-4057qib7 8346 5 13 13 CD cord-005453-4057qib7 8346 6 months month NNS cord-005453-4057qib7 8346 7 of of IN cord-005453-4057qib7 8346 8 transplant transplant NN cord-005453-4057qib7 8346 9 . . . cord-005453-4057qib7 8347 1 The the DT cord-005453-4057qib7 8347 2 4 4 CD cord-005453-4057qib7 8347 3 patients patient NNS cord-005453-4057qib7 8347 4 who who WP cord-005453-4057qib7 8347 5 died die VBD cord-005453-4057qib7 8347 6 had have VBD cord-005453-4057qib7 8347 7 significant significant JJ cord-005453-4057qib7 8347 8 burden burden NN cord-005453-4057qib7 8347 9 of of IN cord-005453-4057qib7 8347 10 disease disease NN cord-005453-4057qib7 8347 11 pre pre VBN cord-005453-4057qib7 8347 12 - - NN cord-005453-4057qib7 8347 13 transplant transplant NN cord-005453-4057qib7 8347 14 : : : cord-005453-4057qib7 8347 15 1 1 CD cord-005453-4057qib7 8347 16 patient patient NN cord-005453-4057qib7 8347 17 had have VBD cord-005453-4057qib7 8347 18 chronic chronic JJ cord-005453-4057qib7 8347 19 liver liver NN cord-005453-4057qib7 8347 20 failure failure NN cord-005453-4057qib7 8347 21 secondary secondary JJ cord-005453-4057qib7 8347 22 to to IN cord-005453-4057qib7 8347 23 cryptosporidial cryptosporidial JJ cord-005453-4057qib7 8347 24 sclerosing sclerosing NN cord-005453-4057qib7 8348 1 cholangitis,1 cholangitis,1 NNP cord-005453-4057qib7 8348 2 had have VBD cord-005453-4057qib7 8348 3 a a DT cord-005453-4057qib7 8348 4 cirrhotic cirrhotic JJ cord-005453-4057qib7 8348 5 liver liver NN cord-005453-4057qib7 8348 6 secondary secondary JJ cord-005453-4057qib7 8348 7 to to IN cord-005453-4057qib7 8348 8 cryptosporidium cryptosporidium NN cord-005453-4057qib7 8348 9 , , , cord-005453-4057qib7 8348 10 cerebral cerebral JJ cord-005453-4057qib7 8348 11 vasculitis vasculitis NN cord-005453-4057qib7 8348 12 , , , cord-005453-4057qib7 8348 13 an an DT cord-005453-4057qib7 8348 14 axillary axillary JJ cord-005453-4057qib7 8348 15 aneurysm aneurysm NN cord-005453-4057qib7 8348 16 and and CC cord-005453-4057qib7 8348 17 aortic aortic JJ cord-005453-4057qib7 8348 18 vasculitis vasculitis NN cord-005453-4057qib7 8348 19 requiring require VBG cord-005453-4057qib7 8348 20 grafting grafting NN cord-005453-4057qib7 8348 21 of of IN cord-005453-4057qib7 8348 22 an an DT cord-005453-4057qib7 8348 23 ascending ascend VBG cord-005453-4057qib7 8348 24 aortic aortic NN cord-005453-4057qib7 8349 1 aneurysm,1 aneurysm,1 NNP cord-005453-4057qib7 8349 2 was be VBD cord-005453-4057qib7 8349 3 PN PN NNP cord-005453-4057qib7 8349 4 dependent dependent JJ cord-005453-4057qib7 8349 5 for for IN cord-005453-4057qib7 8349 6 failure failure NN cord-005453-4057qib7 8349 7 to to TO cord-005453-4057qib7 8349 8 thrive thrive VB cord-005453-4057qib7 8349 9 with with IN cord-005453-4057qib7 8349 10 a a DT cord-005453-4057qib7 8349 11 history history NN cord-005453-4057qib7 8349 12 of of IN cord-005453-4057qib7 8349 13 cryptosporidium cryptosporidium NN cord-005453-4057qib7 8349 14 infection infection NN cord-005453-4057qib7 8349 15 and and CC cord-005453-4057qib7 8349 16 1 1 CD cord-005453-4057qib7 8349 17 had have VBD cord-005453-4057qib7 8349 18 candida candida NN cord-005453-4057qib7 8349 19 in in IN cord-005453-4057qib7 8349 20 a a DT cord-005453-4057qib7 8349 21 BAL bal NN cord-005453-4057qib7 8349 22 pre pre NN cord-005453-4057qib7 8349 23 - - NN cord-005453-4057qib7 8349 24 transplant transplant NN cord-005453-4057qib7 8349 25 . . . cord-005453-4057qib7 8350 1 Causes cause NNS cord-005453-4057qib7 8350 2 of of IN cord-005453-4057qib7 8350 3 death death NN cord-005453-4057qib7 8350 4 in in IN cord-005453-4057qib7 8350 5 these these DT cord-005453-4057qib7 8350 6 patients patient NNS cord-005453-4057qib7 8350 7 were be VBD cord-005453-4057qib7 8350 8 : : : cord-005453-4057qib7 8350 9 respiratory respiratory JJ cord-005453-4057qib7 8350 10 failure failure NN cord-005453-4057qib7 8350 11 ( ( -LRB- cord-005453-4057qib7 8350 12 n=1 n=1 CD cord-005453-4057qib7 8350 13 ) ) -RRB- cord-005453-4057qib7 8350 14 , , , cord-005453-4057qib7 8350 15 progressive progressive JJ cord-005453-4057qib7 8350 16 encephalopathy encephalopathy NN cord-005453-4057qib7 8350 17 ( ( -LRB- cord-005453-4057qib7 8350 18 n=1 n=1 CD cord-005453-4057qib7 8350 19 ) ) -RRB- cord-005453-4057qib7 8350 20 , , , cord-005453-4057qib7 8350 21 multi multi JJ cord-005453-4057qib7 8350 22 - - JJ cord-005453-4057qib7 8350 23 organ organ JJ cord-005453-4057qib7 8350 24 failure failure NN cord-005453-4057qib7 8350 25 with with IN cord-005453-4057qib7 8350 26 septic septic JJ cord-005453-4057qib7 8350 27 shock shock NN cord-005453-4057qib7 8350 28 and and CC cord-005453-4057qib7 8350 29 encephalopathy encephalopathy NN cord-005453-4057qib7 8350 30 ( ( -LRB- cord-005453-4057qib7 8350 31 n=1 n=1 FW cord-005453-4057qib7 8350 32 ) ) -RRB- cord-005453-4057qib7 8350 33 and and CC cord-005453-4057qib7 8350 34 multiorgan multiorgan NN cord-005453-4057qib7 8350 35 failure failure NN cord-005453-4057qib7 8350 36 and and CC cord-005453-4057qib7 8350 37 septic septic JJ cord-005453-4057qib7 8350 38 shock shock NN cord-005453-4057qib7 8350 39 after after IN cord-005453-4057qib7 8350 40 treatment treatment NN cord-005453-4057qib7 8350 41 for for IN cord-005453-4057qib7 8350 42 TMA TMA NNP cord-005453-4057qib7 8350 43 ( ( -LRB- cord-005453-4057qib7 8350 44 n=1 n=1 NN cord-005453-4057qib7 8350 45 ) ) -RRB- cord-005453-4057qib7 8350 46 . . . cord-005453-4057qib7 8351 1 Two two CD cord-005453-4057qib7 8351 2 of of IN cord-005453-4057qib7 8351 3 these these DT cord-005453-4057qib7 8351 4 patients patient NNS cord-005453-4057qib7 8351 5 had have VBD cord-005453-4057qib7 8351 6 reactivation reactivation NN cord-005453-4057qib7 8351 7 of of IN cord-005453-4057qib7 8351 8 cryptosporidium cryptosporidium NN cord-005453-4057qib7 8351 9 prior prior RB cord-005453-4057qib7 8351 10 to to IN cord-005453-4057qib7 8351 11 their -PRON- PRP$ cord-005453-4057qib7 8351 12 death death NN cord-005453-4057qib7 8351 13 . . . cord-005453-4057qib7 8352 1 Pretransplant pretransplant JJ cord-005453-4057qib7 8352 2 cryptosporidium cryptosporidium NN cord-005453-4057qib7 8352 3 was be VBD cord-005453-4057qib7 8352 4 associated associate VBN cord-005453-4057qib7 8352 5 with with IN cord-005453-4057qib7 8352 6 mortality mortality NN cord-005453-4057qib7 8352 7 ( ( -LRB- cord-005453-4057qib7 8352 8 Graph graph NN cord-005453-4057qib7 8352 9 1 1 CD cord-005453-4057qib7 8352 10 ) ) -RRB- cord-005453-4057qib7 8352 11 . . . cord-005453-4057qib7 8353 1 One one CD cord-005453-4057qib7 8353 2 patient patient NN cord-005453-4057qib7 8353 3 who who WP cord-005453-4057qib7 8353 4 survived survive VBD cord-005453-4057qib7 8353 5 had have VBD cord-005453-4057qib7 8353 6 suffered suffer VBN cord-005453-4057qib7 8353 7 from from IN cord-005453-4057qib7 8353 8 stroke stroke NN cord-005453-4057qib7 8353 9 pretransplant pretransplant NN cord-005453-4057qib7 8353 10 . . . cord-005453-4057qib7 8354 1 One one CD cord-005453-4057qib7 8354 2 suffered suffer VBD cord-005453-4057qib7 8354 3 from from IN cord-005453-4057qib7 8354 4 a a DT cord-005453-4057qib7 8354 5 basilar basilar JJ cord-005453-4057qib7 8354 6 artery artery NN cord-005453-4057qib7 8354 7 aneurysm aneurysm NN cord-005453-4057qib7 8354 8 7 7 CD cord-005453-4057qib7 8354 9 years year NNS cord-005453-4057qib7 8354 10 post post JJ cord-005453-4057qib7 8354 11 - - NN cord-005453-4057qib7 8354 12 transplant transplant NN cord-005453-4057qib7 8354 13 at at IN cord-005453-4057qib7 8354 14 19yo 19yo NNP cord-005453-4057qib7 8354 15 . . . cord-005453-4057qib7 8355 1 At at IN cord-005453-4057qib7 8355 2 the the DT cord-005453-4057qib7 8355 3 time time NN cord-005453-4057qib7 8355 4 of of IN cord-005453-4057qib7 8355 5 latest late JJS cord-005453-4057qib7 8355 6 follow follow VB cord-005453-4057qib7 8355 7 up up RP cord-005453-4057qib7 8355 8 donor donor NN cord-005453-4057qib7 8355 9 chimerism chimerism NN cord-005453-4057qib7 8355 10 was be VBD cord-005453-4057qib7 8355 11 100 100 CD cord-005453-4057qib7 8355 12 % % NN cord-005453-4057qib7 8355 13 in in IN cord-005453-4057qib7 8355 14 5/6 5/6 CD cord-005453-4057qib7 8355 15 survivors survivor NNS cord-005453-4057qib7 8355 16 and and CC cord-005453-4057qib7 8355 17 high high JJ cord-005453-4057qib7 8355 18 level level NN cord-005453-4057qib7 8355 19 mixed mix VBN cord-005453-4057qib7 8355 20 in in IN cord-005453-4057qib7 8355 21 the the DT cord-005453-4057qib7 8355 22 other(100 other(100 NNP cord-005453-4057qib7 8355 23 % % NN cord-005453-4057qib7 8355 24 CD3 CD3 NNP cord-005453-4057qib7 8355 25 , , , cord-005453-4057qib7 8355 26 89 89 CD cord-005453-4057qib7 8355 27 % % NN cord-005453-4057qib7 8355 28 CD15 CD15 NNP cord-005453-4057qib7 8355 29 and and CC cord-005453-4057qib7 8355 30 92 92 CD cord-005453-4057qib7 8355 31 % % NN cord-005453-4057qib7 8355 32 CD19 CD19 NNP cord-005453-4057qib7 8355 33 ) ) -RRB- cord-005453-4057qib7 8355 34 . . . cord-005453-4057qib7 8356 1 Conclusions conclusion NNS cord-005453-4057qib7 8356 2 : : : cord-005453-4057qib7 8357 1 This this DT cord-005453-4057qib7 8357 2 single single JJ cord-005453-4057qib7 8357 3 centre centre NN cord-005453-4057qib7 8357 4 study study NN cord-005453-4057qib7 8357 5 of of IN cord-005453-4057qib7 8357 6 HSCT HSCT NNP cord-005453-4057qib7 8357 7 for for IN cord-005453-4057qib7 8357 8 patients patient NNS cord-005453-4057qib7 8357 9 is be VBZ cord-005453-4057qib7 8357 10 consistent consistent JJ cord-005453-4057qib7 8357 11 with with IN cord-005453-4057qib7 8357 12 literature literature NN cord-005453-4057qib7 8357 13 indicating indicate VBG cord-005453-4057qib7 8357 14 that that IN cord-005453-4057qib7 8357 15 HSCT HSCT NNP cord-005453-4057qib7 8357 16 is be VBZ cord-005453-4057qib7 8357 17 a a DT cord-005453-4057qib7 8357 18 potentially potentially RB cord-005453-4057qib7 8357 19 curative curative JJ cord-005453-4057qib7 8357 20 therapy therapy NN cord-005453-4057qib7 8357 21 for for IN cord-005453-4057qib7 8357 22 patients patient NNS cord-005453-4057qib7 8357 23 with with IN cord-005453-4057qib7 8357 24 DOCK dock NN cord-005453-4057qib7 8357 25 8 8 CD cord-005453-4057qib7 8357 26 deficiency deficiency NN cord-005453-4057qib7 8357 27 . . . cord-005453-4057qib7 8358 1 The the DT cord-005453-4057qib7 8358 2 increased increased JJ cord-005453-4057qib7 8358 3 morbidity morbidity NN cord-005453-4057qib7 8358 4 associated associate VBN cord-005453-4057qib7 8358 5 with with IN cord-005453-4057qib7 8358 6 Cryptosporidial cryptosporidial JJ cord-005453-4057qib7 8358 7 infection infection NN cord-005453-4057qib7 8358 8 is be VBZ cord-005453-4057qib7 8358 9 likely likely JJ cord-005453-4057qib7 8358 10 to to TO cord-005453-4057qib7 8358 11 be be VB cord-005453-4057qib7 8358 12 a a DT cord-005453-4057qib7 8358 13 consequence consequence NN cord-005453-4057qib7 8358 14 of of IN cord-005453-4057qib7 8358 15 overall overall JJ cord-005453-4057qib7 8358 16 disease disease NN cord-005453-4057qib7 8358 17 burden burden NN cord-005453-4057qib7 8358 18 rather rather RB cord-005453-4057qib7 8358 19 than than IN cord-005453-4057qib7 8358 20 an an DT cord-005453-4057qib7 8358 21 infection infection NN cord-005453-4057qib7 8358 22 specific specific JJ cord-005453-4057qib7 8358 23 effect effect NN cord-005453-4057qib7 8358 24 . . . cord-005453-4057qib7 8359 1 This this DT cord-005453-4057qib7 8359 2 does do VBZ cord-005453-4057qib7 8359 3 however however RB cord-005453-4057qib7 8359 4 highlight highlight VB cord-005453-4057qib7 8359 5 the the DT cord-005453-4057qib7 8359 6 improved improved JJ cord-005453-4057qib7 8359 7 outcomes outcome NNS cord-005453-4057qib7 8359 8 of of IN cord-005453-4057qib7 8359 9 transplant transplant NN cord-005453-4057qib7 8359 10 prior prior RB cord-005453-4057qib7 8359 11 to to IN cord-005453-4057qib7 8359 12 development development NN cord-005453-4057qib7 8359 13 of of IN cord-005453-4057qib7 8359 14 multiple multiple JJ cord-005453-4057qib7 8359 15 comorbidities comorbiditie NNS cord-005453-4057qib7 8359 16 and and CC cord-005453-4057qib7 8359 17 suggests suggest VBZ cord-005453-4057qib7 8359 18 that that IN cord-005453-4057qib7 8359 19 HSCT HSCT NNP cord-005453-4057qib7 8359 20 should should MD cord-005453-4057qib7 8359 21 be be VB cord-005453-4057qib7 8359 22 considered consider VBN cord-005453-4057qib7 8359 23 early early JJ cord-005453-4057qib7 8359 24 . . . cord-005453-4057qib7 8360 1 It -PRON- PRP cord-005453-4057qib7 8360 2 is be VBZ cord-005453-4057qib7 8360 3 unclear unclear JJ cord-005453-4057qib7 8360 4 whether whether IN cord-005453-4057qib7 8360 5 the the DT cord-005453-4057qib7 8360 6 late late JJ cord-005453-4057qib7 8360 7 occurrence occurrence NN cord-005453-4057qib7 8360 8 of of IN cord-005453-4057qib7 8360 9 vascular vascular JJ cord-005453-4057qib7 8360 10 complications complication NNS cord-005453-4057qib7 8360 11 after after IN cord-005453-4057qib7 8360 12 transplant transplant NN cord-005453-4057qib7 8360 13 were be VBD cord-005453-4057qib7 8360 14 caused cause VBN cord-005453-4057qib7 8360 15 by by IN cord-005453-4057qib7 8360 16 a a DT cord-005453-4057qib7 8360 17 manifestation manifestation NN cord-005453-4057qib7 8360 18 of of IN cord-005453-4057qib7 8360 19 disease disease NN cord-005453-4057qib7 8360 20 which which WDT cord-005453-4057qib7 8360 21 is be VBZ cord-005453-4057qib7 8360 22 not not RB cord-005453-4057qib7 8360 23 corrected correct VBN cord-005453-4057qib7 8360 24 by by IN cord-005453-4057qib7 8360 25 transplant transplant NN cord-005453-4057qib7 8360 26 or or CC cord-005453-4057qib7 8360 27 a a DT cord-005453-4057qib7 8360 28 result result NN cord-005453-4057qib7 8360 29 of of IN cord-005453-4057qib7 8360 30 vascular vascular JJ cord-005453-4057qib7 8360 31 injury injury NN cord-005453-4057qib7 8360 32 sustained sustain VBD cord-005453-4057qib7 8360 33 pre pre JJ cord-005453-4057qib7 8360 34 - - NN cord-005453-4057qib7 8360 35 transplant transplant NN cord-005453-4057qib7 8360 36 . . . cord-005453-4057qib7 8361 1 Reference reference NN cord-005453-4057qib7 8361 2 Methods method NNS cord-005453-4057qib7 8361 3 : : : cord-005453-4057qib7 8362 1 Referred refer VBN cord-005453-4057qib7 8362 2 infants infant NNS cord-005453-4057qib7 8362 3 underwent undergo VBD cord-005453-4057qib7 8362 4 testing test VBG cord-005453-4057qib7 8362 5 for for IN cord-005453-4057qib7 8362 6 : : : cord-005453-4057qib7 8362 7 immune immune JJ cord-005453-4057qib7 8362 8 phenotype phenotype NN cord-005453-4057qib7 8362 9 ( ( -LRB- cord-005453-4057qib7 8362 10 ab ab NNP cord-005453-4057qib7 8362 11 , , , cord-005453-4057qib7 8362 12 gd gd NNP cord-005453-4057qib7 8362 13 , , , cord-005453-4057qib7 8362 14 naïve naïve JJ cord-005453-4057qib7 8362 15 and and CC cord-005453-4057qib7 8362 16 memory memory NN cord-005453-4057qib7 8362 17 T t NN cord-005453-4057qib7 8362 18 cell cell NN cord-005453-4057qib7 8362 19 , , , cord-005453-4057qib7 8362 20 B b NN cord-005453-4057qib7 8362 21 cell cell NN cord-005453-4057qib7 8362 22 and and CC cord-005453-4057qib7 8362 23 NK NK NNP cord-005453-4057qib7 8362 24 cell cell NN cord-005453-4057qib7 8362 25 numbers number NNS cord-005453-4057qib7 8362 26 ) ) -RRB- cord-005453-4057qib7 8362 27 ; ; , cord-005453-4057qib7 8362 28 functional functional JJ cord-005453-4057qib7 8362 29 activity activity NN cord-005453-4057qib7 8362 30 of of IN cord-005453-4057qib7 8362 31 T T NNP cord-005453-4057qib7 8362 32 and and CC cord-005453-4057qib7 8362 33 NK NK NNP cord-005453-4057qib7 8362 34 cells cell NNS cord-005453-4057qib7 8362 35 ; ; : cord-005453-4057qib7 8362 36 maternal maternal JJ cord-005453-4057qib7 8362 37 engraftment engraftment NN cord-005453-4057qib7 8362 38 ; ; : cord-005453-4057qib7 8362 39 adenosine adenosine NN cord-005453-4057qib7 8362 40 deaminase deaminase NNP cord-005453-4057qib7 8362 41 ( ( -LRB- cord-005453-4057qib7 8362 42 ADA ADA NNP cord-005453-4057qib7 8362 43 ) ) -RRB- cord-005453-4057qib7 8362 44 and and CC cord-005453-4057qib7 8362 45 purine purine NN cord-005453-4057qib7 8362 46 nucleoside nucleoside NN cord-005453-4057qib7 8362 47 phosphorylase phosphorylase NN cord-005453-4057qib7 8362 48 ( ( -LRB- cord-005453-4057qib7 8362 49 PNP PNP NNP cord-005453-4057qib7 8362 50 ) ) -RRB- cord-005453-4057qib7 8362 51 enzyme enzyme NN cord-005453-4057qib7 8362 52 activity activity NN cord-005453-4057qib7 8362 53 ; ; : cord-005453-4057qib7 8362 54 and and CC cord-005453-4057qib7 8362 55 genetic genetic JJ cord-005453-4057qib7 8362 56 testing testing NN cord-005453-4057qib7 8362 57 . . . cord-005453-4057qib7 8363 1 Those those DT cord-005453-4057qib7 8363 2 with with IN cord-005453-4057qib7 8363 3 a a DT cord-005453-4057qib7 8363 4 confirmed confirm VBN cord-005453-4057qib7 8363 5 diagnosis diagnosis NN cord-005453-4057qib7 8363 6 of of IN cord-005453-4057qib7 8363 7 SCID SCID NNP cord-005453-4057qib7 8363 8 underwent undergo VBD cord-005453-4057qib7 8363 9 either either CC cord-005453-4057qib7 8363 10 allogeneic allogeneic IN cord-005453-4057qib7 8363 11 hematopoietic hematopoietic JJ cord-005453-4057qib7 8363 12 stem stem NN cord-005453-4057qib7 8363 13 cell cell NN cord-005453-4057qib7 8363 14 transplant transplant NN cord-005453-4057qib7 8363 15 ( ( -LRB- cord-005453-4057qib7 8363 16 HCT HCT NNP cord-005453-4057qib7 8363 17 ) ) -RRB- cord-005453-4057qib7 8363 18 or or CC cord-005453-4057qib7 8363 19 ( ( -LRB- cord-005453-4057qib7 8363 20 if if IN cord-005453-4057qib7 8363 21 eligible eligible JJ cord-005453-4057qib7 8363 22 ) ) -RRB- cord-005453-4057qib7 8363 23 gene gene NN cord-005453-4057qib7 8363 24 therapy therapy NN cord-005453-4057qib7 8363 25 ( ( -LRB- cord-005453-4057qib7 8363 26 GT GT NNP cord-005453-4057qib7 8363 27 ) ) -RRB- cord-005453-4057qib7 8363 28 . . . cord-005453-4057qib7 8364 1 Infants infant NNS cord-005453-4057qib7 8364 2 identified identify VBN cord-005453-4057qib7 8364 3 as as IN cord-005453-4057qib7 8364 4 having have VBG cord-005453-4057qib7 8364 5 ADA ADA NNP cord-005453-4057qib7 8364 6 deficiency deficiency NN cord-005453-4057qib7 8364 7 as as IN cord-005453-4057qib7 8364 8 the the DT cord-005453-4057qib7 8364 9 etiology etiology NN cord-005453-4057qib7 8364 10 of of IN cord-005453-4057qib7 8364 11 their -PRON- PRP$ cord-005453-4057qib7 8364 12 SCID SCID NNP cord-005453-4057qib7 8364 13 received receive VBD cord-005453-4057qib7 8364 14 enzyme enzyme NN cord-005453-4057qib7 8364 15 replacement replacement NN cord-005453-4057qib7 8364 16 therapy therapy NN cord-005453-4057qib7 8364 17 prior prior RB cord-005453-4057qib7 8364 18 to to IN cord-005453-4057qib7 8364 19 proceeding proceed VBG cord-005453-4057qib7 8364 20 to to IN cord-005453-4057qib7 8364 21 definitive definitive JJ cord-005453-4057qib7 8364 22 therapy therapy NN cord-005453-4057qib7 8364 23 . . . cord-005453-4057qib7 8365 1 Results result NNS cord-005453-4057qib7 8365 2 : : : cord-005453-4057qib7 8366 1 Twenty twenty CD cord-005453-4057qib7 8366 2 - - HYPH cord-005453-4057qib7 8366 3 three three CD cord-005453-4057qib7 8366 4 ( ( -LRB- cord-005453-4057qib7 8366 5 66 66 CD cord-005453-4057qib7 8366 6 % % NN cord-005453-4057qib7 8366 7 ) ) -RRB- cord-005453-4057qib7 8366 8 infants infant NNS cord-005453-4057qib7 8366 9 were be VBD cord-005453-4057qib7 8366 10 confirmed confirm VBN cord-005453-4057qib7 8366 11 to to TO cord-005453-4057qib7 8366 12 have have VB cord-005453-4057qib7 8366 13 SCID SCID NNP cord-005453-4057qib7 8366 14 . . . cord-005453-4057qib7 8367 1 Three three CD cord-005453-4057qib7 8367 2 ( ( -LRB- cord-005453-4057qib7 8367 3 13 13 CD cord-005453-4057qib7 8367 4 % % NN cord-005453-4057qib7 8367 5 ) ) -RRB- cord-005453-4057qib7 8367 6 of of IN cord-005453-4057qib7 8367 7 these these DT cord-005453-4057qib7 8367 8 infants infant NNS cord-005453-4057qib7 8367 9 had have VBD cord-005453-4057qib7 8367 10 a a DT cord-005453-4057qib7 8367 11 family family NN cord-005453-4057qib7 8367 12 history history NN cord-005453-4057qib7 8367 13 of of IN cord-005453-4057qib7 8367 14 SCID SCID NNP cord-005453-4057qib7 8367 15 but but CC cord-005453-4057qib7 8367 16 would would MD cord-005453-4057qib7 8367 17 not not RB cord-005453-4057qib7 8367 18 have have VB cord-005453-4057qib7 8367 19 been be VBN cord-005453-4057qib7 8367 20 identified identify VBN cord-005453-4057qib7 8367 21 without without IN cord-005453-4057qib7 8367 22 NBS NBS NNP cord-005453-4057qib7 8367 23 . . . cord-005453-4057qib7 8368 1 In in IN cord-005453-4057qib7 8368 2 addition addition NN cord-005453-4057qib7 8368 3 , , , cord-005453-4057qib7 8368 4 one one CD cord-005453-4057qib7 8368 5 infant infant NN cord-005453-4057qib7 8368 6 , , , cord-005453-4057qib7 8368 7 born bear VBN cord-005453-4057qib7 8368 8 prematurely prematurely RB cord-005453-4057qib7 8368 9 at at IN cord-005453-4057qib7 8368 10 28 28 CD cord-005453-4057qib7 8368 11 weeks week NNS cord-005453-4057qib7 8368 12 , , , cord-005453-4057qib7 8368 13 was be VBD cord-005453-4057qib7 8368 14 diagnosed diagnose VBN cord-005453-4057qib7 8368 15 as as IN cord-005453-4057qib7 8368 16 having have VBG cord-005453-4057qib7 8368 17 PNP PNP NNP cord-005453-4057qib7 8368 18 deficiency deficiency NN cord-005453-4057qib7 8368 19 only only RB cord-005453-4057qib7 8368 20 after after IN cord-005453-4057qib7 8368 21 developing develop VBG cord-005453-4057qib7 8368 22 infections infection NNS cord-005453-4057qib7 8368 23 . . . cord-005453-4057qib7 8369 1 This this DT cord-005453-4057qib7 8369 2 infant infant NN cord-005453-4057qib7 8369 3 was be VBD cord-005453-4057qib7 8369 4 identified identify VBN cord-005453-4057qib7 8369 5 by by IN cord-005453-4057qib7 8369 6 NBS NBS NNP cord-005453-4057qib7 8369 7 but but CC cord-005453-4057qib7 8369 8 repeat repeat VB cord-005453-4057qib7 8369 9 testing testing NN cord-005453-4057qib7 8369 10 at at IN cord-005453-4057qib7 8369 11 32 32 CD cord-005453-4057qib7 8369 12 weeks week NNS cord-005453-4057qib7 8369 13 gestation gestation NN cord-005453-4057qib7 8369 14 was be VBD cord-005453-4057qib7 8369 15 normal normal JJ cord-005453-4057qib7 8369 16 likely likely RB cord-005453-4057qib7 8369 17 due due IN cord-005453-4057qib7 8369 18 to to IN cord-005453-4057qib7 8369 19 support support NN cord-005453-4057qib7 8369 20 of of IN cord-005453-4057qib7 8369 21 transient transient JJ cord-005453-4057qib7 8369 22 T t NN cord-005453-4057qib7 8369 23 cell cell NN cord-005453-4057qib7 8369 24 production production NN cord-005453-4057qib7 8369 25 from from IN cord-005453-4057qib7 8369 26 exogenous exogenous JJ cord-005453-4057qib7 8369 27 enzyme enzyme NN cord-005453-4057qib7 8369 28 provided provide VBN cord-005453-4057qib7 8369 29 by by IN cord-005453-4057qib7 8369 30 red red JJ cord-005453-4057qib7 8369 31 cell cell NN cord-005453-4057qib7 8369 32 transfusion transfusion NN cord-005453-4057qib7 8369 33 . . . cord-005453-4057qib7 8370 1 Twelve twelve CD cord-005453-4057qib7 8370 2 infants infant NNS cord-005453-4057qib7 8370 3 with with IN cord-005453-4057qib7 8370 4 confirmed confirm VBN cord-005453-4057qib7 8370 5 low low JJ cord-005453-4057qib7 8370 6 TRECs trec NNS cord-005453-4057qib7 8370 7 had have VBD cord-005453-4057qib7 8370 8 a a DT cord-005453-4057qib7 8370 9 non non JJ cord-005453-4057qib7 8370 10 - - JJ cord-005453-4057qib7 8370 11 SCID scid JJ cord-005453-4057qib7 8370 12 diagnosis diagnosis NN cord-005453-4057qib7 8370 13 : : : cord-005453-4057qib7 8370 14 5 5 CD cord-005453-4057qib7 8370 15 with with IN cord-005453-4057qib7 8370 16 transient transient JJ cord-005453-4057qib7 8370 17 lymphopenia lymphopenia NN cord-005453-4057qib7 8370 18 of of IN cord-005453-4057qib7 8370 19 infancy infancy NN cord-005453-4057qib7 8370 20 who who WP cord-005453-4057qib7 8370 21 normalized normalize VBD cord-005453-4057qib7 8370 22 TREC TREC NNP cord-005453-4057qib7 8370 23 , , , cord-005453-4057qib7 8370 24 immune immune JJ cord-005453-4057qib7 8370 25 phenotype phenotype NN cord-005453-4057qib7 8370 26 and and CC cord-005453-4057qib7 8370 27 function function NN cord-005453-4057qib7 8370 28 , , , cord-005453-4057qib7 8370 29 1 1 CD cord-005453-4057qib7 8370 30 with with IN cord-005453-4057qib7 8370 31 prenatal prenatal JJ cord-005453-4057qib7 8370 32 exposure exposure NN cord-005453-4057qib7 8370 33 to to IN cord-005453-4057qib7 8370 34 6-mecaptopurine 6-mecaptopurine CD cord-005453-4057qib7 8370 35 ( ( -LRB- cord-005453-4057qib7 8370 36 6-MP 6-mp CD cord-005453-4057qib7 8370 37 ) ) -RRB- cord-005453-4057qib7 8370 38 , , , cord-005453-4057qib7 8370 39 3 3 CD cord-005453-4057qib7 8370 40 genetically genetically RB cord-005453-4057qib7 8370 41 confirmed confirm VBN cord-005453-4057qib7 8370 42 with with IN cord-005453-4057qib7 8370 43 DiGeorge DiGeorge NNP cord-005453-4057qib7 8370 44 Syndrome Syndrome NNP cord-005453-4057qib7 8370 45 , , , cord-005453-4057qib7 8370 46 and and CC cord-005453-4057qib7 8370 47 3 3 CD cord-005453-4057qib7 8370 48 with with IN cord-005453-4057qib7 8370 49 prolonged prolonged JJ cord-005453-4057qib7 8370 50 lymphopenia lymphopenia NNP cord-005453-4057qib7 8370 51 . . . cord-005453-4057qib7 8371 1 Of of IN cord-005453-4057qib7 8371 2 the the DT cord-005453-4057qib7 8371 3 three three CD cord-005453-4057qib7 8371 4 with with IN cord-005453-4057qib7 8371 5 prolonged prolonged JJ cord-005453-4057qib7 8371 6 lymphopenia lymphopenia NNP cord-005453-4057qib7 8371 7 , , , cord-005453-4057qib7 8371 8 two two CD cord-005453-4057qib7 8371 9 had have VBD cord-005453-4057qib7 8371 10 recurrent recurrent JJ cord-005453-4057qib7 8371 11 infections infection NNS cord-005453-4057qib7 8371 12 : : : cord-005453-4057qib7 8371 13 one one CD cord-005453-4057qib7 8371 14 ultimately ultimately RB cord-005453-4057qib7 8371 15 diagnosed diagnose VBN cord-005453-4057qib7 8371 16 with with IN cord-005453-4057qib7 8371 17 Ataxia Ataxia NNP cord-005453-4057qib7 8371 18 Telangiectasia Telangiectasia NNP cord-005453-4057qib7 8371 19 and and CC cord-005453-4057qib7 8371 20 one one CD cord-005453-4057qib7 8371 21 with with IN cord-005453-4057qib7 8371 22 absent absent JJ cord-005453-4057qib7 8371 23 TREC TREC NNP cord-005453-4057qib7 8371 24 but but CC cord-005453-4057qib7 8371 25 near near IN cord-005453-4057qib7 8371 26 normal normal JJ cord-005453-4057qib7 8371 27 number number NN cord-005453-4057qib7 8371 28 of of IN cord-005453-4057qib7 8371 29 T t NN cord-005453-4057qib7 8371 30 cells cell NNS cord-005453-4057qib7 8371 31 , , , cord-005453-4057qib7 8371 32 normal normal JJ cord-005453-4057qib7 8371 33 PHA pha NN cord-005453-4057qib7 8371 34 but but CC cord-005453-4057qib7 8371 35 no no DT cord-005453-4057qib7 8371 36 specific specific JJ cord-005453-4057qib7 8371 37 antigen antigen NN cord-005453-4057qib7 8371 38 responses response NNS cord-005453-4057qib7 8371 39 , , , cord-005453-4057qib7 8371 40 and and CC cord-005453-4057qib7 8371 41 absent absent JJ cord-005453-4057qib7 8371 42 B b NN cord-005453-4057qib7 8371 43 cells cell NNS cord-005453-4057qib7 8371 44 who who WP cord-005453-4057qib7 8371 45 will will MD cord-005453-4057qib7 8371 46 be be VB cord-005453-4057qib7 8371 47 undergoing undergo VBG cord-005453-4057qib7 8371 48 transplant transplant NN cord-005453-4057qib7 8371 49 in in IN cord-005453-4057qib7 8371 50 the the DT cord-005453-4057qib7 8371 51 near near JJ cord-005453-4057qib7 8371 52 future future NN cord-005453-4057qib7 8371 53 . . . cord-005453-4057qib7 8372 1 The the DT cord-005453-4057qib7 8372 2 third third JJ cord-005453-4057qib7 8372 3 continues continue VBZ cord-005453-4057qib7 8372 4 with with IN cord-005453-4057qib7 8372 5 absent absent JJ cord-005453-4057qib7 8372 6 TREC TREC NNP cord-005453-4057qib7 8372 7 , , , cord-005453-4057qib7 8372 8 short short JJ cord-005453-4057qib7 8372 9 telomeres telomere NNS cord-005453-4057qib7 8372 10 , , , cord-005453-4057qib7 8372 11 low low JJ cord-005453-4057qib7 8372 12 numbers number NNS cord-005453-4057qib7 8372 13 of of IN cord-005453-4057qib7 8372 14 a a DT cord-005453-4057qib7 8372 15 / / SYM cord-005453-4057qib7 8372 16 b b NN cord-005453-4057qib7 8372 17 T t NN cord-005453-4057qib7 8372 18 cells cell NNS cord-005453-4057qib7 8372 19 , , , cord-005453-4057qib7 8372 20 presence presence NN cord-005453-4057qib7 8372 21 of of IN cord-005453-4057qib7 8372 22 g g NN cord-005453-4057qib7 8372 23 / / SYM cord-005453-4057qib7 8372 24 d d NNP cord-005453-4057qib7 8372 25 T t NN cord-005453-4057qib7 8372 26 cells cell NNS cord-005453-4057qib7 8372 27 , , , cord-005453-4057qib7 8372 28 vaccine vaccine NN cord-005453-4057qib7 8372 29 responses response NNS cord-005453-4057qib7 8372 30 and and CC cord-005453-4057qib7 8372 31 freedom freedom NN cord-005453-4057qib7 8372 32 from from IN cord-005453-4057qib7 8372 33 infection infection NN cord-005453-4057qib7 8372 34 with with IN cord-005453-4057qib7 8372 35 no no DT cord-005453-4057qib7 8372 36 identified identify VBN cord-005453-4057qib7 8372 37 genetic genetic JJ cord-005453-4057qib7 8372 38 etiology etiology NN cord-005453-4057qib7 8372 39 . . . cord-005453-4057qib7 8373 1 In in IN cord-005453-4057qib7 8373 2 summary summary NN cord-005453-4057qib7 8373 3 , , , cord-005453-4057qib7 8373 4 30 30 CD cord-005453-4057qib7 8373 5 % % NN cord-005453-4057qib7 8373 6 of of IN cord-005453-4057qib7 8373 7 the the DT cord-005453-4057qib7 8373 8 patients patient NNS cord-005453-4057qib7 8373 9 referred refer VBN cord-005453-4057qib7 8373 10 to to IN cord-005453-4057qib7 8373 11 MSK MSK NNP cord-005453-4057qib7 8373 12 with with IN cord-005453-4057qib7 8373 13 confirmed confirm VBN cord-005453-4057qib7 8373 14 abnormal abnormal JJ cord-005453-4057qib7 8373 15 NBS NBS NNP cord-005453-4057qib7 8373 16 for for IN cord-005453-4057qib7 8373 17 SCID SCID NNP cord-005453-4057qib7 8373 18 have have VBP cord-005453-4057qib7 8373 19 a a DT cord-005453-4057qib7 8373 20 non non JJ cord-005453-4057qib7 8373 21 - - JJ cord-005453-4057qib7 8373 22 SCID scid JJ cord-005453-4057qib7 8373 23 diagnosis diagnosis NN cord-005453-4057qib7 8373 24 . . . cord-005453-4057qib7 8374 1 There there EX cord-005453-4057qib7 8374 2 is be VBZ cord-005453-4057qib7 8374 3 no no DT cord-005453-4057qib7 8374 4 uniform uniform JJ cord-005453-4057qib7 8374 5 collection collection NN cord-005453-4057qib7 8374 6 of of IN cord-005453-4057qib7 8374 7 data datum NNS cord-005453-4057qib7 8374 8 for for IN cord-005453-4057qib7 8374 9 these these DT cord-005453-4057qib7 8374 10 infants infant NNS cord-005453-4057qib7 8374 11 and and CC cord-005453-4057qib7 8374 12 the the DT cord-005453-4057qib7 8374 13 threshold threshold NN cord-005453-4057qib7 8374 14 trigger trigger NN cord-005453-4057qib7 8374 15 for for IN cord-005453-4057qib7 8374 16 repeat repeat NN cord-005453-4057qib7 8374 17 testing testing NN cord-005453-4057qib7 8374 18 varies vary VBZ cord-005453-4057qib7 8374 19 from from IN cord-005453-4057qib7 8374 20 state state NN cord-005453-4057qib7 8374 21 to to IN cord-005453-4057qib7 8374 22 state state NN cord-005453-4057qib7 8374 23 , , , cord-005453-4057qib7 8374 24 so so CC cord-005453-4057qib7 8374 25 the the DT cord-005453-4057qib7 8374 26 incidence incidence NN cord-005453-4057qib7 8374 27 of of IN cord-005453-4057qib7 8374 28 significant significant JJ cord-005453-4057qib7 8374 29 non non JJ cord-005453-4057qib7 8374 30 - - JJ cord-005453-4057qib7 8374 31 SCID scid JJ cord-005453-4057qib7 8374 32 disorders disorder NNS cord-005453-4057qib7 8374 33 identified identify VBN cord-005453-4057qib7 8374 34 will will MD cord-005453-4057qib7 8374 35 also also RB cord-005453-4057qib7 8374 36 likely likely RB cord-005453-4057qib7 8374 37 vary vary VB cord-005453-4057qib7 8374 38 from from IN cord-005453-4057qib7 8374 39 state state NN cord-005453-4057qib7 8374 40 to to IN cord-005453-4057qib7 8374 41 state state NN cord-005453-4057qib7 8374 42 . . . cord-005453-4057qib7 8375 1 Although although IN cord-005453-4057qib7 8375 2 our -PRON- PRP$ cord-005453-4057qib7 8375 3 institution institution NN cord-005453-4057qib7 8375 4 specific specific JJ cord-005453-4057qib7 8375 5 experience experience NN cord-005453-4057qib7 8375 6 is be VBZ cord-005453-4057qib7 8375 7 biased biased JJ cord-005453-4057qib7 8375 8 , , , cord-005453-4057qib7 8375 9 as as IN cord-005453-4057qib7 8375 10 most most JJS cord-005453-4057qib7 8375 11 infants infant NNS cord-005453-4057qib7 8375 12 had have VBD cord-005453-4057qib7 8375 13 confirmation confirmation NN cord-005453-4057qib7 8375 14 of of IN cord-005453-4057qib7 8375 15 a a DT cord-005453-4057qib7 8375 16 low low JJ cord-005453-4057qib7 8375 17 number number NN cord-005453-4057qib7 8375 18 of of IN cord-005453-4057qib7 8375 19 TREC TREC NNP cord-005453-4057qib7 8375 20 prior prior RB cord-005453-4057qib7 8375 21 to to IN cord-005453-4057qib7 8375 22 referral referral NN cord-005453-4057qib7 8375 23 , , , cord-005453-4057qib7 8375 24 the the DT cord-005453-4057qib7 8375 25 significant significant JJ cord-005453-4057qib7 8375 26 number number NN cord-005453-4057qib7 8375 27 of of IN cord-005453-4057qib7 8375 28 disorders disorder NNS cord-005453-4057qib7 8375 29 in in IN cord-005453-4057qib7 8375 30 the the DT cord-005453-4057qib7 8375 31 non non JJ cord-005453-4057qib7 8375 32 - - JJ cord-005453-4057qib7 8375 33 SCID scid JJ cord-005453-4057qib7 8375 34 cohort cohort NN cord-005453-4057qib7 8375 35 emphasizes emphasize VBZ cord-005453-4057qib7 8375 36 the the DT cord-005453-4057qib7 8375 37 importance importance NN cord-005453-4057qib7 8375 38 of of IN cord-005453-4057qib7 8375 39 full full JJ cord-005453-4057qib7 8375 40 evaluations evaluation NNS cord-005453-4057qib7 8375 41 and and CC cord-005453-4057qib7 8375 42 follow follow NN cord-005453-4057qib7 8375 43 - - HYPH cord-005453-4057qib7 8375 44 up up NN cord-005453-4057qib7 8375 45 for for IN cord-005453-4057qib7 8375 46 these these DT cord-005453-4057qib7 8375 47 infants infant NNS cord-005453-4057qib7 8375 48 . . . cord-005453-4057qib7 8376 1 Disclosure disclosure NN cord-005453-4057qib7 8376 2 : : : cord-005453-4057qib7 8377 1 None none NN cord-005453-4057qib7 8377 2 of of IN cord-005453-4057qib7 8377 3 these these DT cord-005453-4057qib7 8377 4 relate relate VBP cord-005453-4057qib7 8377 5 to to IN cord-005453-4057qib7 8377 6 the the DT cord-005453-4057qib7 8377 7 work work NN cord-005453-4057qib7 8377 8 being be VBG cord-005453-4057qib7 8377 9 presented present VBN cord-005453-4057qib7 8377 10 . . . cord-005453-4057qib7 8378 1 Susan Susan NNP cord-005453-4057qib7 8378 2 Prockop Prockop NNP cord-005453-4057qib7 8378 3 -research -research : cord-005453-4057qib7 8378 4 funding fund VBG cord-005453-4057qib7 8378 5 Mesoblast Mesoblast NNP cord-005453-4057qib7 8378 6 and and CC cord-005453-4057qib7 8378 7 Atara Atara NNP cord-005453-4057qib7 8378 8 Biotherapeutics Biotherapeutics NNPS cord-005453-4057qib7 8378 9 . . . cord-005453-4057qib7 8379 1 Nancy Nancy NNP cord-005453-4057qib7 8379 2 Kernan Kernan NNP cord-005453-4057qib7 8379 3 -research -research : cord-005453-4057qib7 8379 4 funding fund VBG cord-005453-4057qib7 8379 5 Jaz Jaz NNP cord-005453-4057qib7 8379 6 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 8379 7 . . . cord-005453-4057qib7 8380 1 Richard Richard NNP cord-005453-4057qib7 8381 1 O´Reilly o´reilly RB cord-005453-4057qib7 8381 2 research research NN cord-005453-4057qib7 8381 3 funding funding NN cord-005453-4057qib7 8381 4 and and CC cord-005453-4057qib7 8381 5 royalties royalty NNS cord-005453-4057qib7 8381 6 Atara Atara NNP cord-005453-4057qib7 8381 7 Biotherapeutics Biotherapeutics NNPS cord-005453-4057qib7 8381 8 . . . cord-005453-4057qib7 8382 1 Kevin Kevin NNP cord-005453-4057qib7 8382 2 Curran Curran NNP cord-005453-4057qib7 8382 3 consulting consult VBG cord-005453-4057qib7 8382 4 Juno Juno NNP cord-005453-4057qib7 8382 5 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 8382 6 , , , cord-005453-4057qib7 8382 7 Novartis Novartis NNP cord-005453-4057qib7 8382 8 . . . cord-005453-4057qib7 8383 1 J.J. J.J. NNP cord-005453-4057qib7 8383 2 Boelens Boelens NNP cord-005453-4057qib7 8383 3 Avrobio Avrobio NNP cord-005453-4057qib7 8383 4 , , , cord-005453-4057qib7 8383 5 Magenta Magenta NNP cord-005453-4057qib7 8383 6 , , , cord-005453-4057qib7 8383 7 Chimerix Chimerix NNP cord-005453-4057qib7 8383 8 and and CC cord-005453-4057qib7 8383 9 BlueBird BlueBird NNP cord-005453-4057qib7 8383 10 Bio Bio NNP cord-005453-4057qib7 8383 11 Background Background NNP cord-005453-4057qib7 8383 12 : : : cord-005453-4057qib7 8383 13 Post post JJ cord-005453-4057qib7 8383 14 - - JJ cord-005453-4057qib7 8383 15 transplant transplant JJ cord-005453-4057qib7 8383 16 autoimmune autoimmune NN cord-005453-4057qib7 8383 17 cytopenia cytopenia NNP cord-005453-4057qib7 8383 18 ( ( -LRB- cord-005453-4057qib7 8383 19 AIC AIC NNP cord-005453-4057qib7 8383 20 ) ) -RRB- cord-005453-4057qib7 8383 21 is be VBZ cord-005453-4057qib7 8383 22 challenging challenge VBG cord-005453-4057qib7 8383 23 and and CC cord-005453-4057qib7 8383 24 associated associate VBN cord-005453-4057qib7 8383 25 with with IN cord-005453-4057qib7 8383 26 substantial substantial JJ cord-005453-4057qib7 8383 27 morbidity morbidity NN cord-005453-4057qib7 8383 28 and and CC cord-005453-4057qib7 8383 29 mortality mortality NN cord-005453-4057qib7 8383 30 . . . cord-005453-4057qib7 8384 1 We -PRON- PRP cord-005453-4057qib7 8384 2 aimed aim VBD cord-005453-4057qib7 8384 3 to to TO cord-005453-4057qib7 8384 4 study study VB cord-005453-4057qib7 8384 5 the the DT cord-005453-4057qib7 8384 6 cumulative cumulative JJ cord-005453-4057qib7 8384 7 incidence incidence NN cord-005453-4057qib7 8384 8 ( ( -LRB- cord-005453-4057qib7 8384 9 CI CI NNP cord-005453-4057qib7 8384 10 ) ) -RRB- cord-005453-4057qib7 8384 11 of of IN cord-005453-4057qib7 8384 12 post post JJ cord-005453-4057qib7 8384 13 - - JJ cord-005453-4057qib7 8384 14 HCT hct JJ cord-005453-4057qib7 8384 15 autoimmune autoimmune JJ cord-005453-4057qib7 8384 16 cytopenia cytopenia NN cord-005453-4057qib7 8384 17 ( ( -LRB- cord-005453-4057qib7 8384 18 AIC AIC NNP cord-005453-4057qib7 8384 19 ) ) -RRB- cord-005453-4057qib7 8384 20 and and CC cord-005453-4057qib7 8384 21 its -PRON- PRP$ cord-005453-4057qib7 8384 22 predictors predictor NNS cord-005453-4057qib7 8384 23 in in IN cord-005453-4057qib7 8384 24 a a DT cord-005453-4057qib7 8384 25 cohort cohort NN cord-005453-4057qib7 8384 26 of of IN cord-005453-4057qib7 8384 27 children child NNS cord-005453-4057qib7 8384 28 with with IN cord-005453-4057qib7 8384 29 primary primary JJ cord-005453-4057qib7 8384 30 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8384 31 ( ( -LRB- cord-005453-4057qib7 8384 32 PID PID NNP cord-005453-4057qib7 8384 33 ) ) -RRB- cord-005453-4057qib7 8384 34 . . . cord-005453-4057qib7 8385 1 Methods method NNS cord-005453-4057qib7 8385 2 : : : cord-005453-4057qib7 8385 3 In in IN cord-005453-4057qib7 8385 4 this this DT cord-005453-4057qib7 8385 5 retrospective retrospective JJ cord-005453-4057qib7 8385 6 study study NN cord-005453-4057qib7 8385 7 , , , cord-005453-4057qib7 8385 8 we -PRON- PRP cord-005453-4057qib7 8385 9 included include VBD cord-005453-4057qib7 8385 10 199 199 CD cord-005453-4057qib7 8385 11 children child NNS cord-005453-4057qib7 8385 12 with with IN cord-005453-4057qib7 8385 13 PID PID NNP cord-005453-4057qib7 8385 14 who who WP cord-005453-4057qib7 8385 15 underwent undergo VBD cord-005453-4057qib7 8385 16 their -PRON- PRP$ cord-005453-4057qib7 8385 17 first first JJ cord-005453-4057qib7 8385 18 HSCT HSCT NNP cord-005453-4057qib7 8385 19 with with IN cord-005453-4057qib7 8385 20 fludarabine(F)-Treosulfan(T)±Thiotepa(Thio fludarabine(F)-Treosulfan(T)±Thiotepa(Thio NNP cord-005453-4057qib7 8385 21 ) ) -RRB- cord-005453-4057qib7 8385 22 at at IN cord-005453-4057qib7 8385 23 Great Great NNP cord-005453-4057qib7 8385 24 North North NNP cord-005453-4057qib7 8385 25 Children Children NNPS cord-005453-4057qib7 8385 26 's 's POS cord-005453-4057qib7 8385 27 Hospital Hospital NNP cord-005453-4057qib7 8385 28 from from IN cord-005453-4057qib7 8385 29 2007 2007 CD cord-005453-4057qib7 8385 30 - - SYM cord-005453-4057qib7 8385 31 2017 2017 CD cord-005453-4057qib7 8385 32 . . . cord-005453-4057qib7 8386 1 Main main JJ cord-005453-4057qib7 8386 2 outcomes outcome NNS cord-005453-4057qib7 8386 3 of of IN cord-005453-4057qib7 8386 4 interest interest NN cord-005453-4057qib7 8386 5 were be VBD cord-005453-4057qib7 8386 6 the the DT cord-005453-4057qib7 8386 7 CI CI NNP cord-005453-4057qib7 8386 8 of of IN cord-005453-4057qib7 8386 9 AIC AIC NNP cord-005453-4057qib7 8386 10 and and CC cord-005453-4057qib7 8386 11 its -PRON- PRP$ cord-005453-4057qib7 8386 12 predictors predictor NNS cord-005453-4057qib7 8386 13 . . . cord-005453-4057qib7 8387 1 Fine fine JJ cord-005453-4057qib7 8387 2 - - HYPH cord-005453-4057qib7 8387 3 and and CC cord-005453-4057qib7 8387 4 - - HYPH cord-005453-4057qib7 8387 5 Grey grey JJ cord-005453-4057qib7 8387 6 regression regression NN cord-005453-4057qib7 8387 7 models model NNS cord-005453-4057qib7 8387 8 were be VBD cord-005453-4057qib7 8387 9 used use VBN cord-005453-4057qib7 8387 10 to to TO cord-005453-4057qib7 8387 11 analyse analyse VB cord-005453-4057qib7 8387 12 predictors predictor NNS cord-005453-4057qib7 8387 13 of of IN cord-005453-4057qib7 8387 14 AIC AIC NNP cord-005453-4057qib7 8387 15 , , , cord-005453-4057qib7 8387 16 considering consider VBG cord-005453-4057qib7 8387 17 death death NN cord-005453-4057qib7 8387 18 as as IN cord-005453-4057qib7 8387 19 a a DT cord-005453-4057qib7 8387 20 competing compete VBG cord-005453-4057qib7 8387 21 event event NN cord-005453-4057qib7 8387 22 . . . cord-005453-4057qib7 8388 1 Variables variable NNS cord-005453-4057qib7 8388 2 included include VBN cord-005453-4057qib7 8388 3 were be VBD cord-005453-4057qib7 8388 4 age age NN cord-005453-4057qib7 8388 5 at at IN cord-005453-4057qib7 8388 6 transplant transplant NN cord-005453-4057qib7 8388 7 ( ( -LRB- cord-005453-4057qib7 8388 8 < < NNP cord-005453-4057qib7 8388 9 2.5 2.5 CD cord-005453-4057qib7 8388 10 years year NNS cord-005453-4057qib7 8388 11 vs vs IN cord-005453-4057qib7 8388 12 > > XX cord-005453-4057qib7 8388 13 2.5 2.5 CD cord-005453-4057qib7 8388 14 years year NNS cord-005453-4057qib7 8388 15 ) ) -RRB- cord-005453-4057qib7 8388 16 , , , cord-005453-4057qib7 8388 17 gender gender NN cord-005453-4057qib7 8388 18 , , , cord-005453-4057qib7 8388 19 diagnosis diagnosis NN cord-005453-4057qib7 8388 20 ( ( -LRB- cord-005453-4057qib7 8388 21 SCID SCID NNP cord-005453-4057qib7 8388 22 vs vs IN cord-005453-4057qib7 8388 23 immune immune NN cord-005453-4057qib7 8388 24 - - HYPH cord-005453-4057qib7 8388 25 dysregulatory dysregulatory JJ cord-005453-4057qib7 8388 26 disorders disorder NNS cord-005453-4057qib7 8388 27 vs vs IN cord-005453-4057qib7 8388 28 other other JJ cord-005453-4057qib7 8388 29 PIDs pid NNS cord-005453-4057qib7 8388 30 ) ) -RRB- cord-005453-4057qib7 8388 31 , , , cord-005453-4057qib7 8388 32 pre pre JJ cord-005453-4057qib7 8388 33 - - JJ cord-005453-4057qib7 8388 34 transplant transplant NN cord-005453-4057qib7 8388 35 AIC AIC NNP cord-005453-4057qib7 8388 36 , , , cord-005453-4057qib7 8388 37 pre pre JJ cord-005453-4057qib7 8388 38 - - JJ cord-005453-4057qib7 8388 39 and and CC cord-005453-4057qib7 8388 40 posttransplant posttransplant JJ cord-005453-4057qib7 8388 41 respiratory respiratory JJ cord-005453-4057qib7 8388 42 virus virus NN cord-005453-4057qib7 8388 43 , , , cord-005453-4057qib7 8388 44 donor donor NN cord-005453-4057qib7 8388 45 ( ( -LRB- cord-005453-4057qib7 8388 46 MFD MFD NNP cord-005453-4057qib7 8388 47 vs vs IN cord-005453-4057qib7 8388 48 MUD mud NN cord-005453-4057qib7 8388 49 vs vs IN cord-005453-4057qib7 8388 50 MMFD MMFD NNP cord-005453-4057qib7 8388 51 / / SYM cord-005453-4057qib7 8388 52 MMUD MMUD NNP cord-005453-4057qib7 8388 53 vs vs IN cord-005453-4057qib7 8388 54 haploidentical haploidentical JJ cord-005453-4057qib7 8388 55 donor donor NN cord-005453-4057qib7 8388 56 ) ) -RRB- cord-005453-4057qib7 8388 57 , , , cord-005453-4057qib7 8388 58 ABO ABO NNP cord-005453-4057qib7 8388 59 incompatibility incompatibility NN cord-005453-4057qib7 8388 60 , , , cord-005453-4057qib7 8388 61 conditioning conditioning NN cord-005453-4057qib7 8388 62 ( ( -LRB- cord-005453-4057qib7 8388 63 FT FT NNP cord-005453-4057qib7 8388 64 vs vs IN cord-005453-4057qib7 8388 65 FTThio FTThio NNP cord-005453-4057qib7 8388 66 ) ) -RRB- cord-005453-4057qib7 8388 67 , , , cord-005453-4057qib7 8388 68 serotherapy serotherapy NNP cord-005453-4057qib7 8388 69 ( ( -LRB- cord-005453-4057qib7 8388 70 none none NN cord-005453-4057qib7 8388 71 vs vs IN cord-005453-4057qib7 8388 72 alemtuzumab alemtuzumab NNP cord-005453-4057qib7 8388 73 0.3 0.3 CD cord-005453-4057qib7 8388 74 - - SYM cord-005453-4057qib7 8388 75 0.6 0.6 CD cord-005453-4057qib7 8388 76 mg mg NN cord-005453-4057qib7 8389 1 /kg /kg NFP cord-005453-4057qib7 8389 2 vs vs IN cord-005453-4057qib7 8389 3 alemtuzumab alemtuzumab NNP cord-005453-4057qib7 8389 4 0.9 0.9 CD cord-005453-4057qib7 8389 5 - - HYPH cord-005453-4057qib7 8389 6 1.0mg 1.0mg CD cord-005453-4057qib7 8389 7 / / SYM cord-005453-4057qib7 8389 8 kg kg NN cord-005453-4057qib7 8389 9 vs vs IN cord-005453-4057qib7 8389 10 ATG ATG NNP cord-005453-4057qib7 8389 11 ) ) -RRB- cord-005453-4057qib7 8389 12 , , , cord-005453-4057qib7 8389 13 stem stem VBP cord-005453-4057qib7 8389 14 cell cell NN cord-005453-4057qib7 8389 15 source source NN cord-005453-4057qib7 8390 1 ( ( -LRB- cord-005453-4057qib7 8390 2 marrow marrow NN cord-005453-4057qib7 8390 3 vs vs IN cord-005453-4057qib7 8390 4 PBSC PBSC NNP cord-005453-4057qib7 8390 5 vs vs IN cord-005453-4057qib7 8390 6 cord cord NN cord-005453-4057qib7 8390 7 vs vs IN cord-005453-4057qib7 8390 8 exvivo exvivo NNP cord-005453-4057qib7 8390 9 T T NNP cord-005453-4057qib7 8390 10 depleted deplete VBN cord-005453-4057qib7 8390 11 PBSC PBSC NNP cord-005453-4057qib7 8390 12 ) ) -RRB- cord-005453-4057qib7 8390 13 , , , cord-005453-4057qib7 8390 14 infused infuse VBN cord-005453-4057qib7 8390 15 stem stem NN cord-005453-4057qib7 8390 16 cell cell NN cord-005453-4057qib7 8390 17 doses dose NNS cord-005453-4057qib7 8390 18 ( ( -LRB- cord-005453-4057qib7 8390 19 TNC TNC NNP cord-005453-4057qib7 8390 20 , , , cord-005453-4057qib7 8390 21 CD34 CD34 NNP cord-005453-4057qib7 8390 22 and and CC cord-005453-4057qib7 8390 23 CD3 CD3 NNP cord-005453-4057qib7 8390 24 ) ) -RRB- cord-005453-4057qib7 8390 25 , , , cord-005453-4057qib7 8390 26 aGvHD aGvHD NNP cord-005453-4057qib7 8390 27 ( ( -LRB- cord-005453-4057qib7 8390 28 none none NN cord-005453-4057qib7 8390 29 vs vs IN cord-005453-4057qib7 8390 30 any any DT cord-005453-4057qib7 8390 31 aGvHD agvhd NN cord-005453-4057qib7 8390 32 ) ) -RRB- cord-005453-4057qib7 8390 33 , , , cord-005453-4057qib7 8390 34 cGvHD cGvHD NNP cord-005453-4057qib7 8390 35 ( ( -LRB- cord-005453-4057qib7 8390 36 none none NN cord-005453-4057qib7 8390 37 vs vs IN cord-005453-4057qib7 8390 38 any any DT cord-005453-4057qib7 8390 39 cGvHD cgvhd NN cord-005453-4057qib7 8390 40 ) ) -RRB- cord-005453-4057qib7 8390 41 , , , cord-005453-4057qib7 8390 42 viral viral JJ cord-005453-4057qib7 8390 43 infections infection NNS cord-005453-4057qib7 8390 44 ( ( -LRB- cord-005453-4057qib7 8390 45 CMV CMV NNP cord-005453-4057qib7 8390 46 / / SYM cord-005453-4057qib7 8390 47 adenovirus/ adenovirus/ NN cord-005453-4057qib7 8390 48 EBV EBV NNP cord-005453-4057qib7 8390 49 / / SYM cord-005453-4057qib7 8390 50 HHV6 HHV6 NNP cord-005453-4057qib7 8390 51 viraemia viraemia NN cord-005453-4057qib7 8390 52 ) ) -RRB- cord-005453-4057qib7 8390 53 , , , cord-005453-4057qib7 8390 54 chimerism chimerism NN cord-005453-4057qib7 8390 55 ( ( -LRB- cord-005453-4057qib7 8390 56 full full JJ cord-005453-4057qib7 8390 57 vs vs IN cord-005453-4057qib7 8390 58 mixed mixed JJ cord-005453-4057qib7 8390 59 chimerism chimerism NN cord-005453-4057qib7 8390 60 ( ( -LRB- cord-005453-4057qib7 8390 61 WB WB NNP cord-005453-4057qib7 8390 62 < < XX cord-005453-4057qib7 8390 63 95 95 CD cord-005453-4057qib7 8390 64 % % NN cord-005453-4057qib7 8390 65 ) ) -RRB- cord-005453-4057qib7 8390 66 within within IN cord-005453-4057qib7 8390 67 first first JJ cord-005453-4057qib7 8390 68 year year NN cord-005453-4057qib7 8390 69 post post NN cord-005453-4057qib7 8390 70 - - JJ cord-005453-4057qib7 8390 71 HCT HCT NNP cord-005453-4057qib7 8390 72 ) ) -RRB- cord-005453-4057qib7 8390 73 . . . cord-005453-4057qib7 8391 1 Impact Impact NNP cord-005453-4057qib7 8391 2 of of IN cord-005453-4057qib7 8391 3 thymopoiesis thymopoiesis NN cord-005453-4057qib7 8391 4 using use VBG cord-005453-4057qib7 8391 5 naïve naïve JJ cord-005453-4057qib7 8391 6 T T NNP cord-005453-4057qib7 8391 7 cell cell NN cord-005453-4057qib7 8391 8 recovery recovery NN cord-005453-4057qib7 8391 9 was be VBD cord-005453-4057qib7 8391 10 studied study VBN cord-005453-4057qib7 8391 11 . . . cord-005453-4057qib7 8392 1 Results result NNS cord-005453-4057qib7 8392 2 : : : cord-005453-4057qib7 8393 1 Median median JJ cord-005453-4057qib7 8393 2 age age NN cord-005453-4057qib7 8393 3 at at IN cord-005453-4057qib7 8393 4 transplant transplant NN cord-005453-4057qib7 8393 5 was be VBD cord-005453-4057qib7 8393 6 2.4 2.4 CD cord-005453-4057qib7 8393 7 years year NNS cord-005453-4057qib7 8393 8 ( ( -LRB- cord-005453-4057qib7 8393 9 range range NN cord-005453-4057qib7 8393 10 , , , cord-005453-4057qib7 8393 11 0.11 0.11 CD cord-005453-4057qib7 8393 12 - - SYM cord-005453-4057qib7 8393 13 18.3 18.3 CD cord-005453-4057qib7 8393 14 years year NNS cord-005453-4057qib7 8393 15 ) ) -RRB- cord-005453-4057qib7 8393 16 . . . cord-005453-4057qib7 8394 1 Primary primary JJ cord-005453-4057qib7 8394 2 diagnoses diagnosis NNS cord-005453-4057qib7 8394 3 were be VBD cord-005453-4057qib7 8394 4 SCID SCID NNP cord-005453-4057qib7 8394 5 ( ( -LRB- cord-005453-4057qib7 8394 6 22 22 CD cord-005453-4057qib7 8394 7 % % NN cord-005453-4057qib7 8394 8 ) ) -RRB- cord-005453-4057qib7 8394 9 , , , cord-005453-4057qib7 8394 10 immune immune NN cord-005453-4057qib7 8394 11 - - HYPH cord-005453-4057qib7 8394 12 dysregulatory dysregulatory JJ cord-005453-4057qib7 8394 13 disorders disorder NNS cord-005453-4057qib7 8394 14 ( ( -LRB- cord-005453-4057qib7 8394 15 28 28 CD cord-005453-4057qib7 8394 16 % % NN cord-005453-4057qib7 8394 17 ) ) -RRB- cord-005453-4057qib7 8394 18 and and CC cord-005453-4057qib7 8394 19 other other JJ cord-005453-4057qib7 8394 20 PIDs pid NNS cord-005453-4057qib7 8394 21 ( ( -LRB- cord-005453-4057qib7 8394 22 50 50 CD cord-005453-4057qib7 8394 23 % % NN cord-005453-4057qib7 8394 24 ) ) -RRB- cord-005453-4057qib7 8394 25 . . . cord-005453-4057qib7 8395 1 Donors donor NNS cord-005453-4057qib7 8395 2 were be VBD cord-005453-4057qib7 8395 3 MFD MFD NNP cord-005453-4057qib7 8395 4 ( ( -LRB- cord-005453-4057qib7 8395 5 21 21 CD cord-005453-4057qib7 8395 6 % % NN cord-005453-4057qib7 8395 7 ) ) -RRB- cord-005453-4057qib7 8395 8 , , , cord-005453-4057qib7 8395 9 MUD MUD NNP cord-005453-4057qib7 8395 10 ( ( -LRB- cord-005453-4057qib7 8395 11 48 48 CD cord-005453-4057qib7 8395 12 % % NN cord-005453-4057qib7 8395 13 ) ) -RRB- cord-005453-4057qib7 8395 14 , , , cord-005453-4057qib7 8395 15 MMFD/ MMFD/ NNP cord-005453-4057qib7 8395 16 MMUD MMUD NNP cord-005453-4057qib7 8395 17 ( ( -LRB- cord-005453-4057qib7 8395 18 16 16 CD cord-005453-4057qib7 8395 19 % % NN cord-005453-4057qib7 8395 20 ) ) -RRB- cord-005453-4057qib7 8395 21 and and CC cord-005453-4057qib7 8395 22 haploidentical haploidentical JJ cord-005453-4057qib7 8395 23 parents parent NNS cord-005453-4057qib7 8395 24 ( ( -LRB- cord-005453-4057qib7 8395 25 15 15 CD cord-005453-4057qib7 8395 26 % % NN cord-005453-4057qib7 8395 27 ) ) -RRB- cord-005453-4057qib7 8395 28 . . . cord-005453-4057qib7 8396 1 Stem stem JJ cord-005453-4057qib7 8396 2 cell cell NN cord-005453-4057qib7 8396 3 sources source NNS cord-005453-4057qib7 8396 4 were be VBD cord-005453-4057qib7 8396 5 marrow marrow NN cord-005453-4057qib7 8396 6 ( ( -LRB- cord-005453-4057qib7 8396 7 30 30 CD cord-005453-4057qib7 8396 8 % % NN cord-005453-4057qib7 8396 9 ) ) -RRB- cord-005453-4057qib7 8396 10 , , , cord-005453-4057qib7 8396 11 unmanipulated unmanipulated JJ cord-005453-4057qib7 8396 12 PBSC PBSC NNP cord-005453-4057qib7 8396 13 ( ( -LRB- cord-005453-4057qib7 8396 14 38 38 CD cord-005453-4057qib7 8396 15 % % NN cord-005453-4057qib7 8396 16 ) ) -RRB- cord-005453-4057qib7 8396 17 , , , cord-005453-4057qib7 8396 18 ex ex NN cord-005453-4057qib7 8396 19 - - NN cord-005453-4057qib7 8396 20 vivo vivo JJ cord-005453-4057qib7 8396 21 T t NN cord-005453-4057qib7 8396 22 - - HYPH cord-005453-4057qib7 8396 23 depleted deplete VBN cord-005453-4057qib7 8396 24 PBSC PBSC NNP cord-005453-4057qib7 8396 25 ( ( -LRB- cord-005453-4057qib7 8396 26 23 23 CD cord-005453-4057qib7 8396 27 % % NN cord-005453-4057qib7 8396 28 ) ) -RRB- cord-005453-4057qib7 8396 29 and and CC cord-005453-4057qib7 8396 30 CB CB NNP cord-005453-4057qib7 8396 31 ( ( -LRB- cord-005453-4057qib7 8396 32 9 9 CD cord-005453-4057qib7 8396 33 % % NN cord-005453-4057qib7 8396 34 ) ) -RRB- cord-005453-4057qib7 8396 35 . . . cord-005453-4057qib7 8397 1 16 16 CD cord-005453-4057qib7 8397 2 % % NN cord-005453-4057qib7 8397 3 received receive VBD cord-005453-4057qib7 8397 4 additional additional JJ cord-005453-4057qib7 8397 5 thiotepa thiotepa NNS cord-005453-4057qib7 8397 6 and and CC cord-005453-4057qib7 8397 7 87 87 CD cord-005453-4057qib7 8397 8 % % NN cord-005453-4057qib7 8397 9 had have VBD cord-005453-4057qib7 8397 10 CSA CSA NNP cord-005453-4057qib7 8397 11 / / SYM cord-005453-4057qib7 8397 12 MMF MMF NNP cord-005453-4057qib7 8397 13 as as IN cord-005453-4057qib7 8397 14 GvHD GvHD NNP cord-005453-4057qib7 8397 15 prophylaxis prophylaxis NN cord-005453-4057qib7 8397 16 . . . cord-005453-4057qib7 8398 1 Median median JJ cord-005453-4057qib7 8398 2 duration duration NN cord-005453-4057qib7 8398 3 of of IN cord-005453-4057qib7 8398 4 follow follow NN cord-005453-4057qib7 8398 5 - - HYPH cord-005453-4057qib7 8398 6 up up NN cord-005453-4057qib7 8398 7 of of IN cord-005453-4057qib7 8398 8 survivors survivor NNS cord-005453-4057qib7 8398 9 was be VBD cord-005453-4057qib7 8398 10 2.9 2.9 CD cord-005453-4057qib7 8398 11 years year NNS cord-005453-4057qib7 8398 12 ( ( -LRB- cord-005453-4057qib7 8398 13 range range VBP cord-005453-4057qib7 8398 14 0.2 0.2 CD cord-005453-4057qib7 8398 15 to to IN cord-005453-4057qib7 8398 16 10.2 10.2 CD cord-005453-4057qib7 8398 17 years year NNS cord-005453-4057qib7 8398 18 ) ) -RRB- cord-005453-4057qib7 8398 19 . . . cord-005453-4057qib7 8399 1 5-year 5-year CD cord-005453-4057qib7 8399 2 OS os NN cord-005453-4057qib7 8399 3 for for IN cord-005453-4057qib7 8399 4 the the DT cord-005453-4057qib7 8399 5 entire entire JJ cord-005453-4057qib7 8399 6 cohort cohort NN cord-005453-4057qib7 8399 7 was be VBD cord-005453-4057qib7 8399 8 81 81 CD cord-005453-4057qib7 8399 9 % % NN cord-005453-4057qib7 8399 10 . . . cord-005453-4057qib7 8400 1 6-month 6-month CD cord-005453-4057qib7 8400 2 and and CC cord-005453-4057qib7 8400 3 1-year 1-year CD cord-005453-4057qib7 8400 4 CI CI NNP cord-005453-4057qib7 8400 5 of of IN cord-005453-4057qib7 8400 6 AIC AIC NNP cord-005453-4057qib7 8400 7 were be VBD cord-005453-4057qib7 8400 8 5 5 CD cord-005453-4057qib7 8400 9 % % NN cord-005453-4057qib7 8400 10 and and CC cord-005453-4057qib7 8400 11 13 13 CD cord-005453-4057qib7 8400 12 % % NN cord-005453-4057qib7 8400 13 . . . cord-005453-4057qib7 8401 1 Of of IN cord-005453-4057qib7 8401 2 21 21 CD cord-005453-4057qib7 8401 3 developed develop VBN cord-005453-4057qib7 8401 4 AIC AIC NNP cord-005453-4057qib7 8401 5 , , , cord-005453-4057qib7 8401 6 17 17 CD cord-005453-4057qib7 8401 7 ( ( -LRB- cord-005453-4057qib7 8401 8 80 80 CD cord-005453-4057qib7 8401 9 % % NN cord-005453-4057qib7 8401 10 ) ) -RRB- cord-005453-4057qib7 8401 11 had have VBD cord-005453-4057qib7 8401 12 AIHA AIHA NNP cord-005453-4057qib7 8401 13 , , , cord-005453-4057qib7 8401 14 3 3 CD cord-005453-4057qib7 8401 15 ( ( -LRB- cord-005453-4057qib7 8401 16 15 15 CD cord-005453-4057qib7 8401 17 % % NN cord-005453-4057qib7 8401 18 ) ) -RRB- cord-005453-4057qib7 8402 1 had have VBD cord-005453-4057qib7 8402 2 AIHA±ITP AIHA±ITP NNP cord-005453-4057qib7 8402 3 and and CC cord-005453-4057qib7 8402 4 1 1 CD cord-005453-4057qib7 8402 5 ( ( -LRB- cord-005453-4057qib7 8402 6 5 5 CD cord-005453-4057qib7 8402 7 % % NN cord-005453-4057qib7 8402 8 ) ) -RRB- cord-005453-4057qib7 8402 9 had have VBD cord-005453-4057qib7 8402 10 AIHA AIHA NNP cord-005453-4057qib7 8402 11 ±ITP±AIN ±ITP±AIN NNP cord-005453-4057qib7 8402 12 . . . cord-005453-4057qib7 8403 1 Median median JJ cord-005453-4057qib7 8403 2 onset onset NN cord-005453-4057qib7 8403 3 of of IN cord-005453-4057qib7 8403 4 AIC AIC NNP cord-005453-4057qib7 8403 5 was be VBD cord-005453-4057qib7 8403 6 6.2 6.2 CD cord-005453-4057qib7 8403 7 months month NNS cord-005453-4057qib7 8403 8 post post NN cord-005453-4057qib7 8403 9 - - JJ cord-005453-4057qib7 8403 10 HCT hct JJ cord-005453-4057qib7 8403 11 ( ( -LRB- cord-005453-4057qib7 8403 12 range range VBP cord-005453-4057qib7 8403 13 0.2 0.2 CD cord-005453-4057qib7 8403 14 - - HYPH cord-005453-4057qib7 8403 15 12.8 12.8 CD cord-005453-4057qib7 8403 16 months month NNS cord-005453-4057qib7 8403 17 ) ) -RRB- cord-005453-4057qib7 8403 18 . . . cord-005453-4057qib7 8404 1 Patients patient NNS cord-005453-4057qib7 8404 2 were be VBD cord-005453-4057qib7 8404 3 treated treat VBN cord-005453-4057qib7 8404 4 with with IN cord-005453-4057qib7 8404 5 a a DT cord-005453-4057qib7 8404 6 median median NN cord-005453-4057qib7 8404 7 of of IN cord-005453-4057qib7 8404 8 3 3 CD cord-005453-4057qib7 8404 9 treatment treatment NN cord-005453-4057qib7 8404 10 modalities modality NNS cord-005453-4057qib7 8404 11 ( ( -LRB- cord-005453-4057qib7 8404 12 range range NN cord-005453-4057qib7 8404 13 , , , cord-005453-4057qib7 8404 14 1 1 CD cord-005453-4057qib7 8404 15 - - SYM cord-005453-4057qib7 8404 16 4 4 CD cord-005453-4057qib7 8404 17 ) ) -RRB- cord-005453-4057qib7 8404 18 . . . cord-005453-4057qib7 8405 1 One one CD cord-005453-4057qib7 8405 2 ( ( -LRB- cord-005453-4057qib7 8405 3 5 5 CD cord-005453-4057qib7 8405 4 % % NN cord-005453-4057qib7 8405 5 ) ) -RRB- cord-005453-4057qib7 8405 6 had have VBD cord-005453-4057qib7 8405 7 steroid steroid NN cord-005453-4057qib7 8405 8 , , , cord-005453-4057qib7 8405 9 8 8 CD cord-005453-4057qib7 8405 10 ( ( -LRB- cord-005453-4057qib7 8405 11 38 38 CD cord-005453-4057qib7 8405 12 % % NN cord-005453-4057qib7 8405 13 ) ) -RRB- cord-005453-4057qib7 8405 14 had have VBD cord-005453-4057qib7 8405 15 steroid+high steroid+high NN cord-005453-4057qib7 8405 16 - - HYPH cord-005453-4057qib7 8405 17 dose dose NN cord-005453-4057qib7 8405 18 - - HYPH cord-005453-4057qib7 8405 19 IVIg ivig NN cord-005453-4057qib7 8405 20 , , , cord-005453-4057qib7 8405 21 8 8 CD cord-005453-4057qib7 8405 22 ( ( -LRB- cord-005453-4057qib7 8405 23 38 38 CD cord-005453-4057qib7 8405 24 % % NN cord-005453-4057qib7 8405 25 ) ) -RRB- cord-005453-4057qib7 8405 26 had have VBD cord-005453-4057qib7 8405 27 steroid+high steroid+high NN cord-005453-4057qib7 8405 28 - - HYPH cord-005453-4057qib7 8405 29 dose dose NN cord-005453-4057qib7 8405 30 - - HYPH cord-005453-4057qib7 8405 31 IVIG+rituximab ivig+rituximab NN cord-005453-4057qib7 8405 32 , , , cord-005453-4057qib7 8405 33 1 1 CD cord-005453-4057qib7 8405 34 ( ( -LRB- cord-005453-4057qib7 8405 35 5 5 CD cord-005453-4057qib7 8405 36 % % NN cord-005453-4057qib7 8405 37 ) ) -RRB- cord-005453-4057qib7 8405 38 had have VBD cord-005453-4057qib7 8405 39 steroid steroid JJ cord-005453-4057qib7 8405 40 + + CC cord-005453-4057qib7 8405 41 high high JJ cord-005453-4057qib7 8405 42 - - HYPH cord-005453-4057qib7 8405 43 dose dose NN cord-005453-4057qib7 8405 44 - - HYPH cord-005453-4057qib7 8405 45 IVIG+sirolimus ivig+sirolimus NN cord-005453-4057qib7 8405 46 and and CC cord-005453-4057qib7 8405 47 3 3 CD cord-005453-4057qib7 8405 48 ( ( -LRB- cord-005453-4057qib7 8405 49 14 14 CD cord-005453-4057qib7 8405 50 % % NN cord-005453-4057qib7 8405 51 ) ) -RRB- cord-005453-4057qib7 8405 52 had have VBD cord-005453-4057qib7 8405 53 steroid steroid JJ cord-005453-4057qib7 8405 54 + + CC cord-005453-4057qib7 8405 55 high high JJ cord-005453-4057qib7 8405 56 - - HYPH cord-005453-4057qib7 8405 57 dose dose NN cord-005453-4057qib7 8405 58 - - HYPH cord-005453-4057qib7 8405 59 IVIg+rituximab+sirolimus ivig+rituximab+sirolimus NN cord-005453-4057qib7 8405 60 . . . cord-005453-4057qib7 8406 1 The the DT cord-005453-4057qib7 8406 2 median median JJ cord-005453-4057qib7 8406 3 time time NN cord-005453-4057qib7 8406 4 to to IN cord-005453-4057qib7 8406 5 resolution resolution NN cord-005453-4057qib7 8406 6 in in IN cord-005453-4057qib7 8406 7 18 18 CD cord-005453-4057qib7 8406 8 ( ( -LRB- cord-005453-4057qib7 8406 9 85 85 CD cord-005453-4057qib7 8406 10 % % NN cord-005453-4057qib7 8406 11 ) ) -RRB- cord-005453-4057qib7 8406 12 who who WP cord-005453-4057qib7 8406 13 achieved achieve VBD cord-005453-4057qib7 8406 14 remission remission NN cord-005453-4057qib7 8406 15 after after IN cord-005453-4057qib7 8406 16 first first JJ cord-005453-4057qib7 8406 17 AIC AIC NNP cord-005453-4057qib7 8406 18 was be VBD cord-005453-4057qib7 8406 19 6.5 6.5 CD cord-005453-4057qib7 8406 20 months month NNS cord-005453-4057qib7 8406 21 ( ( -LRB- cord-005453-4057qib7 8406 22 range range VBP cord-005453-4057qib7 8406 23 1.4 1.4 CD cord-005453-4057qib7 8406 24 - - SYM cord-005453-4057qib7 8406 25 28.6 28.6 CD cord-005453-4057qib7 8406 26 months month NNS cord-005453-4057qib7 8406 27 ) ) -RRB- cord-005453-4057qib7 8406 28 . . . cord-005453-4057qib7 8407 1 1 1 CD cord-005453-4057qib7 8407 2 had have VBD cord-005453-4057qib7 8407 3 one one CD cord-005453-4057qib7 8407 4 relapse relapse NN cord-005453-4057qib7 8407 5 and and CC cord-005453-4057qib7 8407 6 2 2 CD cord-005453-4057qib7 8407 7 had have VBD cord-005453-4057qib7 8407 8 two two CD cord-005453-4057qib7 8407 9 relapses relapse NNS cord-005453-4057qib7 8407 10 . . . cord-005453-4057qib7 8408 1 2 2 CD cord-005453-4057qib7 8408 2 died die VBD cord-005453-4057qib7 8408 3 after after IN cord-005453-4057qib7 8408 4 development development NN cord-005453-4057qib7 8408 5 of of IN cord-005453-4057qib7 8408 6 AIC AIC NNP cord-005453-4057qib7 8408 7 ( ( -LRB- cord-005453-4057qib7 8408 8 1 1 CD cord-005453-4057qib7 8408 9 aspergillus aspergillus NN cord-005453-4057qib7 8408 10 pneumonia pneumonia NN cord-005453-4057qib7 8408 11 ; ; : cord-005453-4057qib7 8408 12 1 1 CD cord-005453-4057qib7 8408 13 multi multi JJ cord-005453-4057qib7 8408 14 - - JJ cord-005453-4057qib7 8408 15 organ organ JJ cord-005453-4057qib7 8408 16 failure failure NN cord-005453-4057qib7 8408 17 ) ) -RRB- cord-005453-4057qib7 8408 18 . . . cord-005453-4057qib7 8409 1 Of of IN cord-005453-4057qib7 8409 2 19 19 CD cord-005453-4057qib7 8409 3 ( ( -LRB- cord-005453-4057qib7 8409 4 91 91 CD cord-005453-4057qib7 8409 5 % % NN cord-005453-4057qib7 8409 6 ) ) -RRB- cord-005453-4057qib7 8409 7 surviving survive VBG cord-005453-4057qib7 8409 8 patients patient NNS cord-005453-4057qib7 8409 9 after after IN cord-005453-4057qib7 8409 10 AIC AIC NNP cord-005453-4057qib7 8409 11 , , , cord-005453-4057qib7 8409 12 4 4 CD cord-005453-4057qib7 8409 13 had have VBD cord-005453-4057qib7 8409 14 on on IN cord-005453-4057qib7 8409 15 - - HYPH cord-005453-4057qib7 8409 16 going go VBG cord-005453-4057qib7 8409 17 AIHA AIHA NNP cord-005453-4057qib7 8409 18 at at IN cord-005453-4057qib7 8409 19 median median NN cord-005453-4057qib7 8409 20 of of IN cord-005453-4057qib7 8409 21 follow follow NN cord-005453-4057qib7 8409 22 - - HYPH cord-005453-4057qib7 8409 23 up up NN cord-005453-4057qib7 8409 24 2.5 2.5 CD cord-005453-4057qib7 8409 25 years year NNS cord-005453-4057qib7 8409 26 post post NN cord-005453-4057qib7 8409 27 - - JJ cord-005453-4057qib7 8409 28 HCT hct JJ cord-005453-4057qib7 8409 29 ( ( -LRB- cord-005453-4057qib7 8409 30 range range VBP cord-005453-4057qib7 8409 31 0.9 0.9 CD cord-005453-4057qib7 8409 32 - - SYM cord-005453-4057qib7 8409 33 4.8 4.8 CD cord-005453-4057qib7 8409 34 years year NNS cord-005453-4057qib7 8409 35 ) ) -RRB- cord-005453-4057qib7 8409 36 . . . cord-005453-4057qib7 8410 1 On on IN cord-005453-4057qib7 8410 2 univariate univariate JJ cord-005453-4057qib7 8410 3 completing complete VBG cord-005453-4057qib7 8410 4 - - HYPH cord-005453-4057qib7 8410 5 risk risk NN cord-005453-4057qib7 8410 6 analysis analysis NN cord-005453-4057qib7 8410 7 , , , cord-005453-4057qib7 8410 8 age age NN cord-005453-4057qib7 8410 9 at at IN cord-005453-4057qib7 8410 10 transplant transplant NN cord-005453-4057qib7 8410 11 > > XX cord-005453-4057qib7 8410 12 2.5years 2.5years XX cord-005453-4057qib7 8411 1 ( ( -LRB- cord-005453-4057qib7 8411 2 p=0.02 p=0.02 NN cord-005453-4057qib7 8411 3 ) ) -RRB- cord-005453-4057qib7 8411 4 and and CC cord-005453-4057qib7 8411 5 pre pre JJ cord-005453-4057qib7 8411 6 - - JJ cord-005453-4057qib7 8411 7 transplant transplant NN cord-005453-4057qib7 8411 8 AIC AIC NNP cord-005453-4057qib7 8411 9 ( ( -LRB- cord-005453-4057qib7 8411 10 p=0.02 p=0.02 NNP cord-005453-4057qib7 8411 11 ) ) -RRB- cord-005453-4057qib7 8411 12 were be VBD cord-005453-4057qib7 8411 13 associated associate VBN cord-005453-4057qib7 8411 14 with with IN cord-005453-4057qib7 8411 15 higher high JJR cord-005453-4057qib7 8411 16 incidence incidence NN cord-005453-4057qib7 8411 17 of of IN cord-005453-4057qib7 8411 18 AIC AIC NNP cord-005453-4057qib7 8411 19 ( ( -LRB- cord-005453-4057qib7 8411 20 Figure Figure NNP cord-005453-4057qib7 8411 21 1a 1a CD cord-005453-4057qib7 8411 22 -Ic -ic CD cord-005453-4057qib7 8411 23 ) ) -RRB- cord-005453-4057qib7 8411 24 . . . cord-005453-4057qib7 8412 1 On on IN cord-005453-4057qib7 8412 2 Fine fine JJ cord-005453-4057qib7 8412 3 - - HYPH cord-005453-4057qib7 8412 4 and and CC cord-005453-4057qib7 8412 5 - - HYPH cord-005453-4057qib7 8412 6 grey grey NN cord-005453-4057qib7 8412 7 models model NNS cord-005453-4057qib7 8412 8 , , , cord-005453-4057qib7 8412 9 only only RB cord-005453-4057qib7 8412 10 age age NN cord-005453-4057qib7 8412 11 at at IN cord-005453-4057qib7 8412 12 transplant transplant NN cord-005453-4057qib7 8412 13 ( ( -LRB- cord-005453-4057qib7 8412 14 HR HR NNP cord-005453-4057qib7 8412 15 3.08 3.08 CD cord-005453-4057qib7 8412 16 , , , cord-005453-4057qib7 8412 17 95%CI 95%ci CD cord-005453-4057qib7 8412 18 1.12 1.12 CD cord-005453-4057qib7 8412 19 - - SYM cord-005453-4057qib7 8412 20 8.49 8.49 CD cord-005453-4057qib7 8412 21 , , , cord-005453-4057qib7 8412 22 p=0.03 p=0.03 NNP cord-005453-4057qib7 8412 23 ) ) -RRB- cord-005453-4057qib7 8412 24 was be VBD cord-005453-4057qib7 8412 25 independently independently RB cord-005453-4057qib7 8412 26 associated associate VBN cord-005453-4057qib7 8412 27 with with IN cord-005453-4057qib7 8412 28 AIC AIC NNP cord-005453-4057qib7 8412 29 . . . cord-005453-4057qib7 8413 1 Of of IN cord-005453-4057qib7 8413 2 157 157 CD cord-005453-4057qib7 8413 3 with with IN cord-005453-4057qib7 8413 4 complete complete JJ cord-005453-4057qib7 8413 5 immune immune JJ cord-005453-4057qib7 8413 6 reconstitution reconstitution NN cord-005453-4057qib7 8413 7 data datum NNS cord-005453-4057qib7 8413 8 , , , cord-005453-4057qib7 8413 9 naïve naïve JJ cord-005453-4057qib7 8413 10 T t NN cord-005453-4057qib7 8413 11 cells cell NNS cord-005453-4057qib7 8413 12 > > XX cord-005453-4057qib7 8414 1 100cells 100cells NNP cord-005453-4057qib7 8414 2 / / SYM cord-005453-4057qib7 8414 3 mL ml NN cord-005453-4057qib7 8414 4 at at IN cord-005453-4057qib7 8414 5 6 6 CD cord-005453-4057qib7 8414 6 months month NNS cord-005453-4057qib7 8414 7 post post NN cord-005453-4057qib7 8414 8 - - NN cord-005453-4057qib7 8414 9 HCT HCT NNP cord-005453-4057qib7 8414 10 was be VBD cord-005453-4057qib7 8414 11 associated associate VBN cord-005453-4057qib7 8414 12 lower low JJR cord-005453-4057qib7 8414 13 incidence incidence NN cord-005453-4057qib7 8414 14 of of IN cord-005453-4057qib7 8414 15 AIC AIC NNP cord-005453-4057qib7 8414 16 ( ( -LRB- cord-005453-4057qib7 8414 17 HR HR NNP cord-005453-4057qib7 8414 18 0.36 0.36 CD cord-005453-4057qib7 8414 19 , , , cord-005453-4057qib7 8414 20 95%CI 95%ci CD cord-005453-4057qib7 8414 21 0.15 0.15 CD cord-005453-4057qib7 8414 22 - - HYPH cord-005453-4057qib7 8414 23 0.91 0.91 CD cord-005453-4057qib7 8414 24 , , , cord-005453-4057qib7 8414 25 p=0.03 p=0.03 NN cord-005453-4057qib7 8414 26 ) ) -RRB- cord-005453-4057qib7 8414 27 ( ( -LRB- cord-005453-4057qib7 8414 28 Figure figure NN cord-005453-4057qib7 8414 29 1d 1d CD cord-005453-4057qib7 8414 30 ) ) -RRB- cord-005453-4057qib7 8415 1 Conclusions conclusion NNS cord-005453-4057qib7 8415 2 : : : cord-005453-4057qib7 8416 1 Younger young JJR cord-005453-4057qib7 8416 2 age age NN cord-005453-4057qib7 8416 3 and and CC cord-005453-4057qib7 8416 4 thymopoiesis thymopoiesis NN cord-005453-4057qib7 8416 5 were be VBD cord-005453-4057qib7 8416 6 associated associate VBN cord-005453-4057qib7 8416 7 lower low JJR cord-005453-4057qib7 8416 8 incidence incidence NN cord-005453-4057qib7 8416 9 of of IN cord-005453-4057qib7 8416 10 AIC AIC NNP cord-005453-4057qib7 8416 11 in in IN cord-005453-4057qib7 8416 12 children child NNS cord-005453-4057qib7 8416 13 with with IN cord-005453-4057qib7 8416 14 PID PID NNP cord-005453-4057qib7 8416 15 after after IN cord-005453-4057qib7 8416 16 HCT HCT NNP cord-005453-4057qib7 8416 17 Clinical Clinical NNP cord-005453-4057qib7 8416 18 Background Background NNP cord-005453-4057qib7 8416 19 : : : cord-005453-4057qib7 8417 1 Human human JJ cord-005453-4057qib7 8417 2 heme heme NN cord-005453-4057qib7 8418 1 -oxygenase-1 -oxygenase-1 NFP cord-005453-4057qib7 8418 2 ( ( -LRB- cord-005453-4057qib7 8418 3 HO-1 HO-1 NNP cord-005453-4057qib7 8418 4 ) ) -RRB- cord-005453-4057qib7 8418 5 deficiency deficiency NN cord-005453-4057qib7 8418 6 has have VBZ cord-005453-4057qib7 8418 7 been be VBN cord-005453-4057qib7 8418 8 reported report VBN cord-005453-4057qib7 8418 9 to to TO cord-005453-4057qib7 8418 10 present present VB cord-005453-4057qib7 8418 11 with with IN cord-005453-4057qib7 8418 12 tetrad tetrad NN cord-005453-4057qib7 8418 13 of of IN cord-005453-4057qib7 8418 14 anemia anemia NN cord-005453-4057qib7 8418 15 , , , cord-005453-4057qib7 8418 16 nephritis nephritis NN cord-005453-4057qib7 8418 17 , , , cord-005453-4057qib7 8418 18 inflammation inflammation NN cord-005453-4057qib7 8418 19 and and CC cord-005453-4057qib7 8418 20 asplenia asplenia NN cord-005453-4057qib7 8418 21 and and CC cord-005453-4057qib7 8418 22 is be VBZ cord-005453-4057qib7 8418 23 fatal fatal JJ cord-005453-4057qib7 8418 24 if if IN cord-005453-4057qib7 8418 25 not not RB cord-005453-4057qib7 8418 26 treated treat VBN cord-005453-4057qib7 8418 27 . . . cord-005453-4057qib7 8419 1 Its -PRON- PRP$ cord-005453-4057qib7 8419 2 an an DT cord-005453-4057qib7 8419 3 auto auto NN cord-005453-4057qib7 8419 4 - - HYPH cord-005453-4057qib7 8419 5 inflammatory inflammatory JJ cord-005453-4057qib7 8419 6 disorder disorder NN cord-005453-4057qib7 8419 7 . . . cord-005453-4057qib7 8420 1 Macrophages/ Macrophages/ NNP cord-005453-4057qib7 8420 2 Monocytes Monocytes NNP cord-005453-4057qib7 8420 3 express express VBP cord-005453-4057qib7 8420 4 HO-1 HO-1 NNP cord-005453-4057qib7 8420 5 and and CC cord-005453-4057qib7 8420 6 are be VBP cord-005453-4057qib7 8420 7 engaged engage VBN cord-005453-4057qib7 8420 8 in in IN cord-005453-4057qib7 8420 9 recycling recycling NN cord-005453-4057qib7 8420 10 of of IN cord-005453-4057qib7 8420 11 red red JJ cord-005453-4057qib7 8420 12 cells cell NNS cord-005453-4057qib7 8420 13 . . . cord-005453-4057qib7 8421 1 Human human JJ cord-005453-4057qib7 8421 2 HO-1 HO-1 NNP cord-005453-4057qib7 8421 3 deficiency deficiency NN cord-005453-4057qib7 8421 4 results result NNS cord-005453-4057qib7 8421 5 in in IN cord-005453-4057qib7 8421 6 intravascular intravascular JJ cord-005453-4057qib7 8421 7 hemolysis hemolysis NN cord-005453-4057qib7 8421 8 and and CC cord-005453-4057qib7 8421 9 severe severe JJ cord-005453-4057qib7 8421 10 damage damage NN cord-005453-4057qib7 8421 11 to to IN cord-005453-4057qib7 8421 12 the the DT cord-005453-4057qib7 8421 13 endothelial endothelial JJ cord-005453-4057qib7 8421 14 system system NN cord-005453-4057qib7 8421 15 , , , cord-005453-4057qib7 8421 16 kidneys kidney NNS cord-005453-4057qib7 8421 17 , , , cord-005453-4057qib7 8421 18 and and CC cord-005453-4057qib7 8421 19 other other JJ cord-005453-4057qib7 8421 20 organs organ NNS cord-005453-4057qib7 8421 21 . . . cord-005453-4057qib7 8422 1 Transplantation transplantation NN cord-005453-4057qib7 8422 2 of of IN cord-005453-4057qib7 8422 3 either either DT cord-005453-4057qib7 8422 4 healthy healthy JJ cord-005453-4057qib7 8422 5 wild wild JJ cord-005453-4057qib7 8422 6 type type NN cord-005453-4057qib7 8422 7 macrophages macrophage NNS cord-005453-4057qib7 8422 8 or or CC cord-005453-4057qib7 8422 9 new new JJ cord-005453-4057qib7 8422 10 macrophages macrophage NNS cord-005453-4057qib7 8422 11 produced produce VBN cord-005453-4057qib7 8422 12 by by IN cord-005453-4057qib7 8422 13 SCT SCT NNP cord-005453-4057qib7 8422 14 from from IN cord-005453-4057qib7 8422 15 healthy healthy JJ cord-005453-4057qib7 8422 16 donor donor NN cord-005453-4057qib7 8422 17 has have VBZ cord-005453-4057qib7 8422 18 been be VBN cord-005453-4057qib7 8422 19 proven prove VBN cord-005453-4057qib7 8422 20 to to TO cord-005453-4057qib7 8422 21 be be VB cord-005453-4057qib7 8422 22 curative curative JJ cord-005453-4057qib7 8422 23 for for IN cord-005453-4057qib7 8422 24 HO-1 HO-1 NNP cord-005453-4057qib7 8422 25 deficiency deficiency NN cord-005453-4057qib7 8422 26 in in IN cord-005453-4057qib7 8422 27 mice mouse NNS cord-005453-4057qib7 8422 28 . . . cord-005453-4057qib7 8423 1 In in IN cord-005453-4057qib7 8423 2 2018 2018 CD cord-005453-4057qib7 8423 3 , , , cord-005453-4057qib7 8423 4 we -PRON- PRP cord-005453-4057qib7 8423 5 had have VBD cord-005453-4057qib7 8423 6 reported report VBN cord-005453-4057qib7 8423 7 first first JJ cord-005453-4057qib7 8423 8 successful successful JJ cord-005453-4057qib7 8423 9 allogeneic allogeneic NN cord-005453-4057qib7 8423 10 SCT SCT NNP cord-005453-4057qib7 8423 11 for for IN cord-005453-4057qib7 8423 12 human human JJ cord-005453-4057qib7 8423 13 HO-1 HO-1 NNP cord-005453-4057qib7 8423 14 deficiency deficiency NN cord-005453-4057qib7 8423 15 . . . cord-005453-4057qib7 8424 1 Here here RB cord-005453-4057qib7 8424 2 we -PRON- PRP cord-005453-4057qib7 8424 3 report report VBP cord-005453-4057qib7 8424 4 second second JJ cord-005453-4057qib7 8424 5 successful successful JJ cord-005453-4057qib7 8424 6 non non JJ cord-005453-4057qib7 8424 7 - - JJ cord-005453-4057qib7 8424 8 myeloablative myeloablative JJ cord-005453-4057qib7 8424 9 MSD MSD NNP cord-005453-4057qib7 8424 10 HSCT HSCT NNP cord-005453-4057qib7 8424 11 for for IN cord-005453-4057qib7 8424 12 a a DT cord-005453-4057qib7 8424 13 child child NN cord-005453-4057qib7 8424 14 with with IN cord-005453-4057qib7 8424 15 HO-1 HO-1 NNP cord-005453-4057qib7 8424 16 deficiency deficiency NN cord-005453-4057qib7 8424 17 . . . cord-005453-4057qib7 8425 1 Methods method NNS cord-005453-4057qib7 8425 2 : : : cord-005453-4057qib7 8426 1 A a DT cord-005453-4057qib7 8426 2 9-yr 9-yr JJ cord-005453-4057qib7 8426 3 - - HYPH cord-005453-4057qib7 8426 4 old old JJ cord-005453-4057qib7 8426 5 - - HYPH cord-005453-4057qib7 8426 6 girl girl NN cord-005453-4057qib7 8426 7 presented present VBN cord-005453-4057qib7 8426 8 with with IN cord-005453-4057qib7 8426 9 complaints complaint NNS cord-005453-4057qib7 8426 10 of of IN cord-005453-4057qib7 8426 11 fever fever NN cord-005453-4057qib7 8426 12 , , , cord-005453-4057qib7 8426 13 anemia anemia NN cord-005453-4057qib7 8426 14 and and CC cord-005453-4057qib7 8426 15 severe severe JJ cord-005453-4057qib7 8426 16 hypertension hypertension NN cord-005453-4057qib7 8426 17 . . . cord-005453-4057qib7 8427 1 In in IN cord-005453-4057qib7 8427 2 the the DT cord-005453-4057qib7 8427 3 past past NN cord-005453-4057qib7 8427 4 , , , cord-005453-4057qib7 8427 5 at at IN cord-005453-4057qib7 8427 6 the the DT cord-005453-4057qib7 8427 7 age age NN cord-005453-4057qib7 8427 8 of of IN cord-005453-4057qib7 8427 9 7 7 CD cord-005453-4057qib7 8427 10 years year NNS cord-005453-4057qib7 8427 11 she -PRON- PRP cord-005453-4057qib7 8427 12 was be VBD cord-005453-4057qib7 8427 13 admitted admit VBN cord-005453-4057qib7 8427 14 for for IN cord-005453-4057qib7 8427 15 high high JJ cord-005453-4057qib7 8427 16 fever fever NN cord-005453-4057qib7 8427 17 for for IN cord-005453-4057qib7 8427 18 1 1 CD cord-005453-4057qib7 8427 19 month month NN cord-005453-4057qib7 8427 20 and and CC cord-005453-4057qib7 8427 21 needed need VBD cord-005453-4057qib7 8427 22 blood blood NN cord-005453-4057qib7 8427 23 transfusion transfusion NN cord-005453-4057qib7 8427 24 for for IN cord-005453-4057qib7 8427 25 the the DT cord-005453-4057qib7 8427 26 first first JJ cord-005453-4057qib7 8427 27 time time NN cord-005453-4057qib7 8427 28 for for IN cord-005453-4057qib7 8427 29 severe severe JJ cord-005453-4057qib7 8427 30 anemia anemia NN cord-005453-4057qib7 8427 31 and and CC cord-005453-4057qib7 8427 32 had have VBD cord-005453-4057qib7 8427 33 high high JJ cord-005453-4057qib7 8427 34 platelets platelet NNS cord-005453-4057qib7 8427 35 and and CC cord-005453-4057qib7 8427 36 high high JJ cord-005453-4057qib7 8427 37 ferritin ferritin NN cord-005453-4057qib7 8427 38 . . . cord-005453-4057qib7 8428 1 She -PRON- PRP cord-005453-4057qib7 8428 2 was be VBD cord-005453-4057qib7 8428 3 treated treat VBN cord-005453-4057qib7 8428 4 as as IN cord-005453-4057qib7 8428 5 macrophage macrophage NN cord-005453-4057qib7 8428 6 activation activation NN cord-005453-4057qib7 8428 7 syndrome syndrome NN cord-005453-4057qib7 8428 8 with with IN cord-005453-4057qib7 8428 9 prednisolone prednisolone NNP cord-005453-4057qib7 8428 10 alone alone RB cord-005453-4057qib7 8428 11 and and CC cord-005453-4057qib7 8428 12 later later RB cord-005453-4057qib7 8428 13 cyclosporine cyclosporine NN cord-005453-4057qib7 8428 14 was be VBD cord-005453-4057qib7 8428 15 added add VBN cord-005453-4057qib7 8428 16 . . . cord-005453-4057qib7 8429 1 She -PRON- PRP cord-005453-4057qib7 8429 2 had have VBD cord-005453-4057qib7 8429 3 short short JJ cord-005453-4057qib7 8429 4 stature stature NN cord-005453-4057qib7 8429 5 , , , cord-005453-4057qib7 8429 6 abnormal abnormal JJ cord-005453-4057qib7 8429 7 facies facie NNS cord-005453-4057qib7 8429 8 but but CC cord-005453-4057qib7 8429 9 normal normal JJ cord-005453-4057qib7 8429 10 development development NN cord-005453-4057qib7 8429 11 . . . cord-005453-4057qib7 8430 1 Hemoglobin hemoglobin NN cord-005453-4057qib7 8430 2 9 9 CD cord-005453-4057qib7 8431 1 g g NNP cord-005453-4057qib7 8431 2 / / SYM cord-005453-4057qib7 8431 3 dl dl NN cord-005453-4057qib7 8431 4 , , , cord-005453-4057qib7 8431 5 urine urine NN cord-005453-4057qib7 8431 6 for for IN cord-005453-4057qib7 8431 7 haemoglobin haemoglobin NN cord-005453-4057qib7 8431 8 was be VBD cord-005453-4057qib7 8431 9 positive positive JJ cord-005453-4057qib7 8431 10 , , , cord-005453-4057qib7 8431 11 platelets platelet NNS cord-005453-4057qib7 8432 1 1055 1055 CD cord-005453-4057qib7 8432 2 , , , cord-005453-4057qib7 8432 3 000 000 CD cord-005453-4057qib7 8432 4 / / SYM cord-005453-4057qib7 8432 5 ul ul NN cord-005453-4057qib7 8432 6 , , , cord-005453-4057qib7 8432 7 ferritin ferritin NN cord-005453-4057qib7 8432 8 2568 2568 CD cord-005453-4057qib7 8432 9 mcg mcg NNP cord-005453-4057qib7 8432 10 / / SYM cord-005453-4057qib7 8432 11 L l NN cord-005453-4057qib7 8432 12 and and CC cord-005453-4057qib7 8432 13 urine urine NN cord-005453-4057qib7 8432 14 albumin albumin NN cord-005453-4057qib7 8432 15 4 4 CD cord-005453-4057qib7 8433 1 + + CC cord-005453-4057qib7 8434 1 and and CC cord-005453-4057qib7 8434 2 Urine Urine NNP cord-005453-4057qib7 8434 3 RBC RBC NNP cord-005453-4057qib7 8434 4 20 20 CD cord-005453-4057qib7 8434 5 - - SYM cord-005453-4057qib7 8434 6 30 30 CD cord-005453-4057qib7 8434 7 / / SYM cord-005453-4057qib7 8434 8 hpf hpf NN cord-005453-4057qib7 8434 9 . . . cord-005453-4057qib7 8435 1 Ultrasound ultrasound NN cord-005453-4057qib7 8435 2 and and CC cord-005453-4057qib7 8435 3 CT CT NNP cord-005453-4057qib7 8435 4 scan scan JJ cord-005453-4057qib7 8435 5 abdomen abdoman NNS cord-005453-4057qib7 8435 6 showed show VBD cord-005453-4057qib7 8435 7 asplenia asplenia NN cord-005453-4057qib7 8435 8 . . . cord-005453-4057qib7 8436 1 A a DT cord-005453-4057qib7 8436 2 diagnosis diagnosis NN cord-005453-4057qib7 8436 3 of of IN cord-005453-4057qib7 8436 4 HO-1 HO-1 NNP cord-005453-4057qib7 8436 5 deficiency deficiency NN cord-005453-4057qib7 8436 6 was be VBD cord-005453-4057qib7 8436 7 suspected suspect VBN cord-005453-4057qib7 8436 8 . . . cord-005453-4057qib7 8437 1 Mutation mutation NN cord-005453-4057qib7 8437 2 analysis analysis NN cord-005453-4057qib7 8437 3 showed show VBD cord-005453-4057qib7 8437 4 homozygous homozygous JJ cord-005453-4057qib7 8437 5 missense missense NN cord-005453-4057qib7 8437 6 mutations mutation NNS cord-005453-4057qib7 8437 7 in in IN cord-005453-4057qib7 8437 8 exon2 exon2 NN cord-005453-4057qib7 8437 9 ( ( -LRB- cord-005453-4057qib7 8437 10 R44X R44X NNP cord-005453-4057qib7 8437 11 ) ) -RRB- cord-005453-4057qib7 8437 12 on on IN cord-005453-4057qib7 8437 13 chromosome chromosome NN cord-005453-4057qib7 8437 14 22q12 22q12 CD cord-005453-4057qib7 8437 15 , , , cord-005453-4057qib7 8437 16 which which WDT cord-005453-4057qib7 8437 17 would would MD cord-005453-4057qib7 8437 18 result result VB cord-005453-4057qib7 8437 19 in in IN cord-005453-4057qib7 8437 20 the the DT cord-005453-4057qib7 8437 21 absence absence NN cord-005453-4057qib7 8437 22 of of IN cord-005453-4057qib7 8437 23 the the DT cord-005453-4057qib7 8437 24 functional functional JJ cord-005453-4057qib7 8437 25 HO-1 HO-1 NNP cord-005453-4057qib7 8437 26 protein protein NN cord-005453-4057qib7 8437 27 . . . cord-005453-4057qib7 8438 1 Both both DT cord-005453-4057qib7 8438 2 parents parent NNS cord-005453-4057qib7 8438 3 were be VBD cord-005453-4057qib7 8438 4 carriers carrier NNS cord-005453-4057qib7 8438 5 of of IN cord-005453-4057qib7 8438 6 this this DT cord-005453-4057qib7 8438 7 mutation mutation NN cord-005453-4057qib7 8438 8 . . . cord-005453-4057qib7 8439 1 We -PRON- PRP cord-005453-4057qib7 8439 2 managed manage VBD cord-005453-4057qib7 8439 3 her -PRON- PRP cord-005453-4057qib7 8439 4 over over IN cord-005453-4057qib7 8439 5 next next JJ cord-005453-4057qib7 8439 6 6-years 6-years CD cord-005453-4057qib7 8439 7 with with IN cord-005453-4057qib7 8439 8 prednisolone prednisolone NNP cord-005453-4057qib7 8439 9 , , , cord-005453-4057qib7 8439 10 hydroxyurea hydroxyurea NNP cord-005453-4057qib7 8439 11 and and CC cord-005453-4057qib7 8439 12 mycophenolate mycophenolate NNP cord-005453-4057qib7 8439 13 mofetil mofetil NNP cord-005453-4057qib7 8439 14 ( ( -LRB- cord-005453-4057qib7 8439 15 MMF MMF NNP cord-005453-4057qib7 8439 16 ) ) -RRB- cord-005453-4057qib7 8439 17 . . . cord-005453-4057qib7 8440 1 However however RB cord-005453-4057qib7 8440 2 she -PRON- PRP cord-005453-4057qib7 8440 3 remained remain VBD cord-005453-4057qib7 8440 4 steroid steroid JJ cord-005453-4057qib7 8440 5 dependent dependent JJ cord-005453-4057qib7 8440 6 . . . cord-005453-4057qib7 8441 1 HLA HLA NNP cord-005453-4057qib7 8441 2 - - HYPH cord-005453-4057qib7 8441 3 typing typing NN cord-005453-4057qib7 8441 4 confirmed confirm VBD cord-005453-4057qib7 8441 5 her -PRON- PRP cord-005453-4057qib7 8441 6 healthy healthy JJ cord-005453-4057qib7 8441 7 unaffected unaffected JJ cord-005453-4057qib7 8441 8 13-year 13-year JJ cord-005453-4057qib7 8441 9 - - HYPH cord-005453-4057qib7 8441 10 old old JJ cord-005453-4057qib7 8441 11 brother brother NN cord-005453-4057qib7 8441 12 to to TO cord-005453-4057qib7 8441 13 be be VB cord-005453-4057qib7 8441 14 a a DT cord-005453-4057qib7 8441 15 fully fully RB cord-005453-4057qib7 8441 16 matched match VBN cord-005453-4057qib7 8441 17 donor donor NN cord-005453-4057qib7 8441 18 . . . cord-005453-4057qib7 8442 1 At at IN cord-005453-4057qib7 8442 2 the the DT cord-005453-4057qib7 8442 3 age age NN cord-005453-4057qib7 8442 4 of of IN cord-005453-4057qib7 8442 5 16 16 CD cord-005453-4057qib7 8442 6 years year NNS cord-005453-4057qib7 8442 7 she -PRON- PRP cord-005453-4057qib7 8442 8 was be VBD cord-005453-4057qib7 8442 9 taken take VBN cord-005453-4057qib7 8442 10 up up RP cord-005453-4057qib7 8442 11 for for IN cord-005453-4057qib7 8442 12 MSD MSD NNP cord-005453-4057qib7 8442 13 SCT SCT NNP cord-005453-4057qib7 8442 14 after after IN cord-005453-4057qib7 8442 15 taking take VBG cord-005453-4057qib7 8442 16 informed informed JJ cord-005453-4057qib7 8442 17 consent consent NN cord-005453-4057qib7 8442 18 . . . cord-005453-4057qib7 8443 1 She -PRON- PRP cord-005453-4057qib7 8443 2 weighed weigh VBD cord-005453-4057qib7 8443 3 just just RB cord-005453-4057qib7 8443 4 16 16 CD cord-005453-4057qib7 8443 5 kg kg NNS cord-005453-4057qib7 8443 6 . . . cord-005453-4057qib7 8444 1 We -PRON- PRP cord-005453-4057qib7 8444 2 conditioned condition VBD cord-005453-4057qib7 8444 3 her -PRON- PRP cord-005453-4057qib7 8444 4 with with IN cord-005453-4057qib7 8444 5 Alemtuzumab-0.8mg Alemtuzumab-0.8mg NNP cord-005453-4057qib7 8444 6 / / SYM cord-005453-4057qib7 8444 7 kg kg NN cord-005453-4057qib7 8444 8 , , , cord-005453-4057qib7 8444 9 Fludarabine-160mg Fludarabine-160mg NNP cord-005453-4057qib7 8444 10 / / SYM cord-005453-4057qib7 8444 11 m2 m2 NNP cord-005453-4057qib7 8444 12 , , , cord-005453-4057qib7 8444 13 Cyclophospamide-29mg Cyclophospamide-29mg NNP cord-005453-4057qib7 8444 14 / / SYM cord-005453-4057qib7 8444 15 kg kg NNP cord-005453-4057qib7 8444 16 and and CC cord-005453-4057qib7 8444 17 Total total JJ cord-005453-4057qib7 8444 18 body body NN cord-005453-4057qib7 8444 19 irradiation irradiation NN cord-005453-4057qib7 8444 20 2 2 CD cord-005453-4057qib7 8444 21 Gray Gray NNP cord-005453-4057qib7 8444 22 . . . cord-005453-4057qib7 8445 1 We -PRON- PRP cord-005453-4057qib7 8445 2 infused infuse VBD cord-005453-4057qib7 8445 3 9 9 CD cord-005453-4057qib7 8445 4 million million CD cord-005453-4057qib7 8445 5 / / SYM cord-005453-4057qib7 8445 6 kg kg CD cord-005453-4057qib7 8445 7 peripheral peripheral JJ cord-005453-4057qib7 8445 8 blood blood NN cord-005453-4057qib7 8445 9 stem stem NN cord-005453-4057qib7 8445 10 cells cell NNS cord-005453-4057qib7 8445 11 from from IN cord-005453-4057qib7 8445 12 her -PRON- PRP$ cord-005453-4057qib7 8445 13 brother brother NN cord-005453-4057qib7 8445 14 . . . cord-005453-4057qib7 8446 1 Graft graft NN cord-005453-4057qib7 8446 2 - - HYPH cord-005453-4057qib7 8446 3 vs.-Host vs.-host NN cord-005453-4057qib7 8446 4 disease disease NN cord-005453-4057qib7 8446 5 ( ( -LRB- cord-005453-4057qib7 8446 6 GVHD GVHD NNP cord-005453-4057qib7 8446 7 ) ) -RRB- cord-005453-4057qib7 8446 8 prophylaxis prophylaxis NN cord-005453-4057qib7 8446 9 consisted consist VBD cord-005453-4057qib7 8446 10 of of IN cord-005453-4057qib7 8446 11 tacrolimus tacrolimus NNP cord-005453-4057qib7 8446 12 & & CC cord-005453-4057qib7 8446 13 MMF MMF NNP cord-005453-4057qib7 8446 14 . . . cord-005453-4057qib7 8447 1 Results result NNS cord-005453-4057qib7 8447 2 : : : cord-005453-4057qib7 8448 1 She -PRON- PRP cord-005453-4057qib7 8448 2 tolerated tolerate VBD cord-005453-4057qib7 8448 3 procedure procedure NN cord-005453-4057qib7 8448 4 very very RB cord-005453-4057qib7 8448 5 well well RB cord-005453-4057qib7 8448 6 . . . cord-005453-4057qib7 8449 1 Her -PRON- PRP$ cord-005453-4057qib7 8449 2 entire entire JJ cord-005453-4057qib7 8449 3 hospital hospital NN cord-005453-4057qib7 8449 4 stay stay NN cord-005453-4057qib7 8449 5 was be VBD cord-005453-4057qib7 8449 6 uneventful uneventful JJ cord-005453-4057qib7 8449 7 and and CC cord-005453-4057qib7 8450 1 lowest low JJS cord-005453-4057qib7 8450 2 platelet platelet NN cord-005453-4057qib7 8450 3 count count NN cord-005453-4057qib7 8450 4 recorded record VBN cord-005453-4057qib7 8450 5 was be VBD cord-005453-4057qib7 8450 6 30,000 30,000 CD cord-005453-4057qib7 8450 7 / / SYM cord-005453-4057qib7 8450 8 ul ul NN cord-005453-4057qib7 8450 9 . . . cord-005453-4057qib7 8451 1 Her -PRON- PRP$ cord-005453-4057qib7 8451 2 neutrophils neutrophil NNS cord-005453-4057qib7 8451 3 engrafted engraft VBN cord-005453-4057qib7 8451 4 on on IN cord-005453-4057qib7 8451 5 day day NN cord-005453-4057qib7 8451 6 +13 +13 NN cord-005453-4057qib7 8451 7 and and CC cord-005453-4057qib7 8451 8 she -PRON- PRP cord-005453-4057qib7 8451 9 was be VBD cord-005453-4057qib7 8451 10 discharged discharge VBN cord-005453-4057qib7 8451 11 on on IN cord-005453-4057qib7 8451 12 day+19 day+19 NNP cord-005453-4057qib7 8451 13 . . . cord-005453-4057qib7 8452 1 His -PRON- PRP$ cord-005453-4057qib7 8452 2 urine urine NN cord-005453-4057qib7 8452 3 albumin albumin NN cord-005453-4057qib7 8452 4 was be VBD cord-005453-4057qib7 8452 5 nil nil NN cord-005453-4057qib7 8452 6 by by IN cord-005453-4057qib7 8452 7 day+7 day+7 NNS cord-005453-4057qib7 8452 8 . . . cord-005453-4057qib7 8453 1 She -PRON- PRP cord-005453-4057qib7 8453 2 had have VBD cord-005453-4057qib7 8453 3 no no DT cord-005453-4057qib7 8453 4 GVHD GVHD NNP cord-005453-4057qib7 8453 5 . . . cord-005453-4057qib7 8454 1 Her -PRON- PRP$ cord-005453-4057qib7 8454 2 chimerism chimerism NN cord-005453-4057qib7 8454 3 on on IN cord-005453-4057qib7 8454 4 day+22 day+22 NNP cord-005453-4057qib7 8454 5 showed show VBD cord-005453-4057qib7 8454 6 97 97 CD cord-005453-4057qib7 8454 7 % % NN cord-005453-4057qib7 8454 8 donor donor NN cord-005453-4057qib7 8454 9 cells cell NNS cord-005453-4057qib7 8454 10 , , , cord-005453-4057qib7 8454 11 on on IN cord-005453-4057qib7 8454 12 day+60 day+60 NNP cord-005453-4057qib7 8454 13 was be VBD cord-005453-4057qib7 8454 14 98 98 CD cord-005453-4057qib7 8454 15 % % NN cord-005453-4057qib7 8454 16 and and CC cord-005453-4057qib7 8454 17 on on IN cord-005453-4057qib7 8454 18 day+180 day+180 NNP cord-005453-4057qib7 8454 19 was be VBD cord-005453-4057qib7 8454 20 98 98 CD cord-005453-4057qib7 8454 21 % % NN cord-005453-4057qib7 8454 22 donor donor NN cord-005453-4057qib7 8454 23 . . . cord-005453-4057qib7 8455 1 Now now RB cord-005453-4057qib7 8455 2 he -PRON- PRP cord-005453-4057qib7 8455 3 is be VBZ cord-005453-4057qib7 8455 4 day+210 day+210 NNP cord-005453-4057qib7 8455 5 post post JJ cord-005453-4057qib7 8455 6 - - JJ cord-005453-4057qib7 8455 7 SCT SCT NNP cord-005453-4057qib7 8455 8 and and CC cord-005453-4057qib7 8455 9 doing do VBG cord-005453-4057qib7 8455 10 well well RB cord-005453-4057qib7 8455 11 . . . cord-005453-4057qib7 8456 1 She -PRON- PRP cord-005453-4057qib7 8456 2 has have VBZ cord-005453-4057qib7 8456 3 no no DT cord-005453-4057qib7 8456 4 evidence evidence NN cord-005453-4057qib7 8456 5 of of IN cord-005453-4057qib7 8456 6 hemolysis hemolysis NN cord-005453-4057qib7 8456 7 , , , cord-005453-4057qib7 8456 8 proteinuria proteinuria NN cord-005453-4057qib7 8456 9 , , , cord-005453-4057qib7 8456 10 hypertension hypertension NN cord-005453-4057qib7 8456 11 , , , cord-005453-4057qib7 8456 12 fever fever NN cord-005453-4057qib7 8456 13 . . . cord-005453-4057qib7 8457 1 She -PRON- PRP cord-005453-4057qib7 8457 2 has have VBZ cord-005453-4057qib7 8457 3 normal normal JJ cord-005453-4057qib7 8457 4 ferritin ferritin NN cord-005453-4057qib7 8457 5 and and CC cord-005453-4057qib7 8457 6 platelets platelet NNS cord-005453-4057qib7 8457 7 . . . cord-005453-4057qib7 8458 1 She -PRON- PRP cord-005453-4057qib7 8458 2 has have VBZ cord-005453-4057qib7 8458 3 gained gain VBN cord-005453-4057qib7 8458 4 3 3 CD cord-005453-4057qib7 8458 5 cm cm NN cord-005453-4057qib7 8458 6 height height NN cord-005453-4057qib7 8458 7 and and CC cord-005453-4057qib7 8458 8 5 5 CD cord-005453-4057qib7 8458 9 kg kg NN cord-005453-4057qib7 8458 10 weight weight NN cord-005453-4057qib7 8458 11 in in IN cord-005453-4057qib7 8458 12 last last JJ cord-005453-4057qib7 8458 13 7 7 CD cord-005453-4057qib7 8458 14 months month NNS cord-005453-4057qib7 8458 15 . . . cord-005453-4057qib7 8459 1 She -PRON- PRP cord-005453-4057qib7 8459 2 had have VBD cord-005453-4057qib7 8459 3 no no DT cord-005453-4057qib7 8459 4 viral viral JJ cord-005453-4057qib7 8459 5 reactivation reactivation NN cord-005453-4057qib7 8459 6 and and CC cord-005453-4057qib7 8459 7 her -PRON- PRP$ cord-005453-4057qib7 8459 8 immune immune JJ cord-005453-4057qib7 8459 9 recovery recovery NN cord-005453-4057qib7 8459 10 at at IN cord-005453-4057qib7 8459 11 6 6 CD cord-005453-4057qib7 8459 12 months month NNS cord-005453-4057qib7 8459 13 post post NN cord-005453-4057qib7 8460 1 SCT SCT NNP cord-005453-4057qib7 8460 2 is be VBZ cord-005453-4057qib7 8460 3 good good JJ cord-005453-4057qib7 8460 4 . . . cord-005453-4057qib7 8461 1 Conclusions conclusion NNS cord-005453-4057qib7 8461 2 : : : cord-005453-4057qib7 8462 1 Non non JJ cord-005453-4057qib7 8462 2 - - JJ cord-005453-4057qib7 8462 3 myeoablative myeoablative JJ cord-005453-4057qib7 8462 4 allogeneic allogeneic NN cord-005453-4057qib7 8462 5 MSD MSD NNP cord-005453-4057qib7 8462 6 SCT SCT NNP cord-005453-4057qib7 8462 7 is be VBZ cord-005453-4057qib7 8462 8 a a DT cord-005453-4057qib7 8462 9 curative curative JJ cord-005453-4057qib7 8462 10 treatment treatment NN cord-005453-4057qib7 8462 11 option option NN cord-005453-4057qib7 8462 12 for for IN cord-005453-4057qib7 8462 13 human human JJ cord-005453-4057qib7 8462 14 HO-1 HO-1 NNP cord-005453-4057qib7 8462 15 deficiency deficiency NN cord-005453-4057qib7 8462 16 . . . cord-005453-4057qib7 8463 1 Disclosure disclosure NN cord-005453-4057qib7 8463 2 : : : cord-005453-4057qib7 8464 1 Nil Nil NNP cord-005453-4057qib7 8464 2 Two two CD cord-005453-4057qib7 8464 3 decades decade NNS cord-005453-4057qib7 8464 4 of of IN cord-005453-4057qib7 8464 5 excellent excellent JJ cord-005453-4057qib7 8464 6 transplant transplant NN cord-005453-4057qib7 8464 7 survival survival NN cord-005453-4057qib7 8464 8 in in IN cord-005453-4057qib7 8464 9 children child NNS cord-005453-4057qib7 8464 10 with with IN cord-005453-4057qib7 8464 11 chronic chronic JJ cord-005453-4057qib7 8464 12 granulomatous granulomatous JJ cord-005453-4057qib7 8464 13 disease disease NN cord-005453-4057qib7 8464 14 : : : cord-005453-4057qib7 8464 15 A a DT cord-005453-4057qib7 8464 16 report report NN cord-005453-4057qib7 8464 17 from from IN cord-005453-4057qib7 8464 18 a a DT cord-005453-4057qib7 8464 19 supraregional supraregional JJ cord-005453-4057qib7 8464 20 immunology immunology NN cord-005453-4057qib7 8464 21 transplant transplant NN cord-005453-4057qib7 8464 22 centre centre NN cord-005453-4057qib7 8464 23 in in IN cord-005453-4057qib7 8464 24 Europe Europe NNP cord-005453-4057qib7 8464 25 Background Background NNP cord-005453-4057qib7 8464 26 : : : cord-005453-4057qib7 8464 27 Haematopoietic haematopoietic JJ cord-005453-4057qib7 8464 28 stem stem NN cord-005453-4057qib7 8464 29 cell cell NN cord-005453-4057qib7 8464 30 transplantation transplantation NN cord-005453-4057qib7 8464 31 ( ( -LRB- cord-005453-4057qib7 8464 32 HSCT HSCT NNP cord-005453-4057qib7 8464 33 ) ) -RRB- cord-005453-4057qib7 8464 34 confers confer VBZ cord-005453-4057qib7 8464 35 life life NN cord-005453-4057qib7 8464 36 - - HYPH cord-005453-4057qib7 8464 37 long long JJ cord-005453-4057qib7 8464 38 curative curative JJ cord-005453-4057qib7 8464 39 therapy therapy NN cord-005453-4057qib7 8464 40 for for IN cord-005453-4057qib7 8464 41 chronic chronic JJ cord-005453-4057qib7 8464 42 granulomatous granulomatous JJ cord-005453-4057qib7 8464 43 disease disease NN cord-005453-4057qib7 8464 44 ( ( -LRB- cord-005453-4057qib7 8464 45 CGD CGD NNP cord-005453-4057qib7 8464 46 ) ) -RRB- cord-005453-4057qib7 8464 47 . . . cord-005453-4057qib7 8465 1 The the DT cord-005453-4057qib7 8465 2 ability ability NN cord-005453-4057qib7 8465 3 of of IN cord-005453-4057qib7 8465 4 donor donor NN cord-005453-4057qib7 8465 5 - - HYPH cord-005453-4057qib7 8465 6 derived derive VBN cord-005453-4057qib7 8465 7 neutrophils neutrophil NNS cord-005453-4057qib7 8465 8 to to TO cord-005453-4057qib7 8465 9 replace replace VB cord-005453-4057qib7 8465 10 recipient recipient NN cord-005453-4057qib7 8465 11 's 's POS cord-005453-4057qib7 8465 12 defective defective JJ cord-005453-4057qib7 8465 13 neutrophils neutrophil NNS cord-005453-4057qib7 8465 14 makes make VBZ cord-005453-4057qib7 8465 15 HSCT HSCT NNP cord-005453-4057qib7 8465 16 a a DT cord-005453-4057qib7 8465 17 superior superior JJ cord-005453-4057qib7 8465 18 therapy therapy NN cord-005453-4057qib7 8465 19 compared compare VBN cord-005453-4057qib7 8465 20 to to IN cord-005453-4057qib7 8465 21 conventional conventional JJ cord-005453-4057qib7 8465 22 standard standard NN cord-005453-4057qib7 8465 23 of of IN cord-005453-4057qib7 8465 24 care care NN cord-005453-4057qib7 8465 25 using use VBG cord-005453-4057qib7 8465 26 antimicrobial antimicrobial JJ cord-005453-4057qib7 8465 27 therapy therapy NN cord-005453-4057qib7 8465 28 . . . cord-005453-4057qib7 8466 1 Methods method NNS cord-005453-4057qib7 8467 1 : : : cord-005453-4057qib7 8467 2 We -PRON- PRP cord-005453-4057qib7 8467 3 examined examine VBD cord-005453-4057qib7 8467 4 the the DT cord-005453-4057qib7 8467 5 outcome outcome NN cord-005453-4057qib7 8467 6 of of IN cord-005453-4057qib7 8467 7 children child NNS cord-005453-4057qib7 8467 8 with with IN cord-005453-4057qib7 8467 9 CGD CGD NNP cord-005453-4057qib7 8467 10 who who WP cord-005453-4057qib7 8467 11 received receive VBD cord-005453-4057qib7 8467 12 a a DT cord-005453-4057qib7 8467 13 first first JJ cord-005453-4057qib7 8467 14 HSCT HSCT NNP cord-005453-4057qib7 8467 15 at at IN cord-005453-4057qib7 8467 16 Great Great NNP cord-005453-4057qib7 8467 17 North North NNP cord-005453-4057qib7 8467 18 Children Children NNPS cord-005453-4057qib7 8467 19 's 's POS cord-005453-4057qib7 8467 20 Hospital Hospital NNP cord-005453-4057qib7 8467 21 from from IN cord-005453-4057qib7 8467 22 1998 1998 CD cord-005453-4057qib7 8467 23 to to IN cord-005453-4057qib7 8467 24 2017 2017 CD cord-005453-4057qib7 8467 25 . . . cord-005453-4057qib7 8468 1 Outcomes outcome NNS cord-005453-4057qib7 8468 2 included include VBD cord-005453-4057qib7 8468 3 overall overall JJ cord-005453-4057qib7 8468 4 survival survival NN cord-005453-4057qib7 8468 5 ( ( -LRB- cord-005453-4057qib7 8468 6 OS OS NNP cord-005453-4057qib7 8468 7 ) ) -RRB- cord-005453-4057qib7 8468 8 , , , cord-005453-4057qib7 8468 9 event event NN cord-005453-4057qib7 8468 10 - - HYPH cord-005453-4057qib7 8468 11 free free JJ cord-005453-4057qib7 8468 12 survival survival NN cord-005453-4057qib7 8468 13 ( ( -LRB- cord-005453-4057qib7 8468 14 ES ES NNP cord-005453-4057qib7 8468 15 ) ) -RRB- cord-005453-4057qib7 8468 16 , , , cord-005453-4057qib7 8468 17 toxicity toxicity NN cord-005453-4057qib7 8468 18 endpoints endpoint NNS cord-005453-4057qib7 8468 19 , , , cord-005453-4057qib7 8468 20 autoimmune autoimmune JJ cord-005453-4057qib7 8468 21 disease disease NN cord-005453-4057qib7 8468 22 , , , cord-005453-4057qib7 8468 23 long long JJ cord-005453-4057qib7 8468 24 - - HYPH cord-005453-4057qib7 8468 25 term term NN cord-005453-4057qib7 8468 26 survival survival NN cord-005453-4057qib7 8468 27 and and CC cord-005453-4057qib7 8468 28 graft graft NN cord-005453-4057qib7 8468 29 function function NN cord-005453-4057qib7 8468 30 . . . cord-005453-4057qib7 8469 1 Cox Cox NNP cord-005453-4057qib7 8469 2 proportional proportional JJ cord-005453-4057qib7 8469 3 - - HYPH cord-005453-4057qib7 8469 4 hazard hazard NN cord-005453-4057qib7 8469 5 models model NNS cord-005453-4057qib7 8469 6 were be VBD cord-005453-4057qib7 8469 7 used use VBN cord-005453-4057qib7 8469 8 to to TO cord-005453-4057qib7 8469 9 analyse analyse VB cord-005453-4057qib7 8469 10 predictors predictor NNS cord-005453-4057qib7 8469 11 of of IN cord-005453-4057qib7 8469 12 OS OS NNP cord-005453-4057qib7 8469 13 and and CC cord-005453-4057qib7 8469 14 ES ES NNP cord-005453-4057qib7 8469 15 . . . cord-005453-4057qib7 8470 1 Variables variable NNS cord-005453-4057qib7 8470 2 included include VBN cord-005453-4057qib7 8470 3 for for IN cord-005453-4057qib7 8470 4 predictor predictor NN cord-005453-4057qib7 8470 5 analysis analysis NN cord-005453-4057qib7 8470 6 were be VBD cord-005453-4057qib7 8470 7 age age NN cord-005453-4057qib7 8470 8 at at IN cord-005453-4057qib7 8470 9 transplant transplant NN cord-005453-4057qib7 8470 10 , , , cord-005453-4057qib7 8470 11 donor donor NN cord-005453-4057qib7 8470 12 , , , cord-005453-4057qib7 8470 13 stem stem NN cord-005453-4057qib7 8470 14 cell cell NN cord-005453-4057qib7 8470 15 source source NN cord-005453-4057qib7 8470 16 , , , cord-005453-4057qib7 8470 17 stem stem NN cord-005453-4057qib7 8470 18 cell cell NN cord-005453-4057qib7 8470 19 doses dose NNS cord-005453-4057qib7 8470 20 and and CC cord-005453-4057qib7 8470 21 conditioning conditioning NN cord-005453-4057qib7 8470 22 . . . cord-005453-4057qib7 8471 1 Results result NNS cord-005453-4057qib7 8471 2 : : : cord-005453-4057qib7 8471 3 = = NFP cord-005453-4057qib7 8472 1 55 55 CD cord-005453-4057qib7 8472 2 children child NNS cord-005453-4057qib7 8472 3 were be VBD cord-005453-4057qib7 8472 4 included include VBN cord-005453-4057qib7 8472 5 in in IN cord-005453-4057qib7 8472 6 this this DT cord-005453-4057qib7 8472 7 analysis analysis NN cord-005453-4057qib7 8472 8 . . . cord-005453-4057qib7 8473 1 Median median JJ cord-005453-4057qib7 8473 2 age age NN cord-005453-4057qib7 8473 3 of of IN cord-005453-4057qib7 8473 4 transplant transplant NN cord-005453-4057qib7 8473 5 was be VBD cord-005453-4057qib7 8473 6 5.3 5.3 CD cord-005453-4057qib7 8473 7 years year NNS cord-005453-4057qib7 8473 8 ( ( -LRB- cord-005453-4057qib7 8473 9 range range NN cord-005453-4057qib7 8473 10 , , , cord-005453-4057qib7 8473 11 0.6 0.6 CD cord-005453-4057qib7 8473 12 - - SYM cord-005453-4057qib7 8473 13 18.0 18.0 CD cord-005453-4057qib7 8473 14 years year NNS cord-005453-4057qib7 8473 15 ) ) -RRB- cord-005453-4057qib7 8473 16 . . . cord-005453-4057qib7 8474 1 45 45 CD cord-005453-4057qib7 8474 2 ( ( -LRB- cord-005453-4057qib7 8474 3 82 82 CD cord-005453-4057qib7 8474 4 % % NN cord-005453-4057qib7 8474 5 ) ) -RRB- cord-005453-4057qib7 8474 6 had have VBD cord-005453-4057qib7 8474 7 X x NN cord-005453-4057qib7 8474 8 - - HYPH cord-005453-4057qib7 8474 9 linked link VBN cord-005453-4057qib7 8474 10 and and CC cord-005453-4057qib7 8474 11 10 10 CD cord-005453-4057qib7 8474 12 ( ( -LRB- cord-005453-4057qib7 8474 13 18 18 CD cord-005453-4057qib7 8474 14 % % NN cord-005453-4057qib7 8474 15 ) ) -RRB- cord-005453-4057qib7 8474 16 autosomal autosomal JJ cord-005453-4057qib7 8474 17 recessive recessive JJ cord-005453-4057qib7 8474 18 CGD CGD NNP cord-005453-4057qib7 8474 19 . . . cord-005453-4057qib7 8475 1 Twenty twenty CD cord-005453-4057qib7 8475 2 ( ( -LRB- cord-005453-4057qib7 8475 3 36 36 CD cord-005453-4057qib7 8475 4 % % NN cord-005453-4057qib7 8475 5 ) ) -RRB- cord-005453-4057qib7 8475 6 had have VBD cord-005453-4057qib7 8475 7 matched match VBN cord-005453-4057qib7 8475 8 family family NN cord-005453-4057qib7 8475 9 donor donor NN cord-005453-4057qib7 8475 10 , , , cord-005453-4057qib7 8475 11 31 31 CD cord-005453-4057qib7 8475 12 ( ( -LRB- cord-005453-4057qib7 8475 13 56 56 CD cord-005453-4057qib7 8475 14 % % NN cord-005453-4057qib7 8475 15 ) ) -RRB- cord-005453-4057qib7 8475 16 had have VBD cord-005453-4057qib7 8475 17 unrelated unrelated JJ cord-005453-4057qib7 8475 18 donor donor NN cord-005453-4057qib7 8475 19 and and CC cord-005453-4057qib7 8475 20 4 4 CD cord-005453-4057qib7 8475 21 ( ( -LRB- cord-005453-4057qib7 8475 22 8 8 CD cord-005453-4057qib7 8475 23 % % NN cord-005453-4057qib7 8475 24 ) ) -RRB- cord-005453-4057qib7 8475 25 had have VBD cord-005453-4057qib7 8475 26 parental parental JJ cord-005453-4057qib7 8475 27 haploidentical haploidentical JJ cord-005453-4057qib7 8475 28 donor donor NN cord-005453-4057qib7 8475 29 . . . cord-005453-4057qib7 8476 1 Prior prior RB cord-005453-4057qib7 8476 2 to to IN cord-005453-4057qib7 8476 3 2007 2007 CD cord-005453-4057qib7 8476 4 , , , cord-005453-4057qib7 8476 5 various various JJ cord-005453-4057qib7 8476 6 conditioning conditioning NN cord-005453-4057qib7 8476 7 regimens regimen NNS cord-005453-4057qib7 8476 8 were be VBD cord-005453-4057qib7 8476 9 used use VBN cord-005453-4057qib7 8476 10 , , , cord-005453-4057qib7 8476 11 with with IN cord-005453-4057qib7 8476 12 21 21 CD cord-005453-4057qib7 8476 13 ( ( -LRB- cord-005453-4057qib7 8476 14 38 38 CD cord-005453-4057qib7 8476 15 % % NN cord-005453-4057qib7 8476 16 ) ) -RRB- cord-005453-4057qib7 8476 17 patients patient NNS cord-005453-4057qib7 8476 18 undergoing undergo VBG cord-005453-4057qib7 8476 19 conditioning conditioning NN cord-005453-4057qib7 8476 20 with with IN cord-005453-4057qib7 8476 21 pharmacokinetic pharmacokinetic JJ cord-005453-4057qib7 8476 22 guided guide VBN cord-005453-4057qib7 8476 23 intravenous intravenous JJ cord-005453-4057qib7 8476 24 ( ( -LRB- cord-005453-4057qib7 8476 25 IV IV NNP cord-005453-4057qib7 8476 26 ) ) -RRB- cord-005453-4057qib7 8476 27 busulfan busulfan NNP cord-005453-4057qib7 8476 28 ( ( -LRB- cord-005453-4057qib7 8476 29 Bu Bu NNP cord-005453-4057qib7 8476 30 ) ) -RRB- cord-005453-4057qib7 8476 31 and and CC cord-005453-4057qib7 8476 32 IV IV NNP cord-005453-4057qib7 8476 33 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 8476 34 with with IN cord-005453-4057qib7 8476 35 or or CC cord-005453-4057qib7 8476 36 without without IN cord-005453-4057qib7 8476 37 serotherapy serotherapy NNP cord-005453-4057qib7 8476 38 . . . cord-005453-4057qib7 8477 1 From from IN cord-005453-4057qib7 8477 2 2007 2007 CD cord-005453-4057qib7 8477 3 , , , cord-005453-4057qib7 8477 4 the the DT cord-005453-4057qib7 8477 5 conditioning conditioning NN cord-005453-4057qib7 8477 6 regimen regimen NN cord-005453-4057qib7 8477 7 was be VBD cord-005453-4057qib7 8477 8 switched switch VBN cord-005453-4057qib7 8477 9 to to IN cord-005453-4057qib7 8477 10 Flu Flu NNP cord-005453-4057qib7 8477 11 - - HYPH cord-005453-4057qib7 8477 12 Treosulfan Treosulfan NNP cord-005453-4057qib7 8477 13 - - HYPH cord-005453-4057qib7 8477 14 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 8477 15 with with IN cord-005453-4057qib7 8477 16 GvHD GvHD NNP cord-005453-4057qib7 8477 17 prophylaxis prophylaxis NN cord-005453-4057qib7 8477 18 using use VBG cord-005453-4057qib7 8477 19 ciclosporin ciclosporin NNP cord-005453-4057qib7 8477 20 ( ( -LRB- cord-005453-4057qib7 8477 21 CSA CSA NNP cord-005453-4057qib7 8477 22 ) ) -RRB- cord-005453-4057qib7 8477 23 and and CC cord-005453-4057qib7 8477 24 mycophenolate mycophenolate NNP cord-005453-4057qib7 8477 25 mofetil mofetil NNP cord-005453-4057qib7 8477 26 ( ( -LRB- cord-005453-4057qib7 8477 27 MMF MMF NNP cord-005453-4057qib7 8477 28 ) ) -RRB- cord-005453-4057qib7 8477 29 for for IN cord-005453-4057qib7 8477 30 family family NN cord-005453-4057qib7 8477 31 and and CC cord-005453-4057qib7 8477 32 unrelated unrelated JJ cord-005453-4057qib7 8477 33 donors donor NNS cord-005453-4057qib7 8477 34 ( ( -LRB- cord-005453-4057qib7 8477 35 n=24 n=24 NNP cord-005453-4057qib7 8477 36 , , , cord-005453-4057qib7 8477 37 44 44 CD cord-005453-4057qib7 8477 38 % % NN cord-005453-4057qib7 8477 39 ) ) -RRB- cord-005453-4057qib7 8477 40 . . . cord-005453-4057qib7 8478 1 Flu Flu NNP cord-005453-4057qib7 8478 2 - - HYPH cord-005453-4057qib7 8478 3 Treosulfan Treosulfan NNP cord-005453-4057qib7 8478 4 - - HYPH cord-005453-4057qib7 8478 5 Thiotepa Thiotepa NNP cord-005453-4057qib7 8478 6 - - HYPH cord-005453-4057qib7 8478 7 ATG ATG NNP cord-005453-4057qib7 8478 8 - - HYPH cord-005453-4057qib7 8478 9 Rituximab Rituximab NNP cord-005453-4057qib7 8478 10 was be VBD cord-005453-4057qib7 8478 11 used use VBN cord-005453-4057qib7 8478 12 for for IN cord-005453-4057qib7 8478 13 CD3 CD3 NNP cord-005453-4057qib7 8479 1 TCR TCR NNP cord-005453-4057qib7 8479 2 alpha alpha NN cord-005453-4057qib7 8479 3 - - HYPH cord-005453-4057qib7 8479 4 beta beta NN cord-005453-4057qib7 8480 1 CD19 CD19 NNP cord-005453-4057qib7 8480 2 depleted deplete VBD cord-005453-4057qib7 8480 3 haploidentical haploidentical JJ cord-005453-4057qib7 8480 4 grafts graft NNS cord-005453-4057qib7 8480 5 ( ( -LRB- cord-005453-4057qib7 8480 6 n=4 n=4 JJ cord-005453-4057qib7 8480 7 , , , cord-005453-4057qib7 8480 8 7 7 CD cord-005453-4057qib7 8480 9 % % NN cord-005453-4057qib7 8480 10 ) ) -RRB- cord-005453-4057qib7 8480 11 . . . cord-005453-4057qib7 8481 1 Ten ten CD cord-005453-4057qib7 8481 2 ( ( -LRB- cord-005453-4057qib7 8481 3 20 20 CD cord-005453-4057qib7 8481 4 % % NN cord-005453-4057qib7 8481 5 ) ) -RRB- cord-005453-4057qib7 8481 6 patients patient NNS cord-005453-4057qib7 8481 7 had have VBD cord-005453-4057qib7 8481 8 grade grade NN cord-005453-4057qib7 8481 9 II II NNP cord-005453-4057qib7 8481 10 - - HYPH cord-005453-4057qib7 8481 11 IV IV NNP cord-005453-4057qib7 8481 12 acute acute JJ cord-005453-4057qib7 8481 13 GvHD GvHD NNP cord-005453-4057qib7 8481 14 while while IN cord-005453-4057qib7 8481 15 5 5 CD cord-005453-4057qib7 8481 16 had have VBD cord-005453-4057qib7 8481 17 ( ( -LRB- cord-005453-4057qib7 8481 18 9 9 CD cord-005453-4057qib7 8481 19 % % NN cord-005453-4057qib7 8481 20 ) ) -RRB- cord-005453-4057qib7 8481 21 had have VBD cord-005453-4057qib7 8481 22 grade grade NN cord-005453-4057qib7 8481 23 III III NNP cord-005453-4057qib7 8481 24 - - HYPH cord-005453-4057qib7 8481 25 IV IV NNP cord-005453-4057qib7 8481 26 acute acute JJ cord-005453-4057qib7 8481 27 GvHD GvHD NNP cord-005453-4057qib7 8481 28 . . . cord-005453-4057qib7 8482 1 None none NN cord-005453-4057qib7 8482 2 had have VBD cord-005453-4057qib7 8482 3 chronic chronic JJ cord-005453-4057qib7 8482 4 GvHD GvHD NNP cord-005453-4057qib7 8482 5 . . . cord-005453-4057qib7 8483 1 The the DT cord-005453-4057qib7 8483 2 5-year 5-year CD cord-005453-4057qib7 8483 3 OS os NN cord-005453-4057qib7 8483 4 for for IN cord-005453-4057qib7 8483 5 the the DT cord-005453-4057qib7 8483 6 entire entire JJ cord-005453-4057qib7 8483 7 cohort cohort NN cord-005453-4057qib7 8483 8 was be VBD cord-005453-4057qib7 8483 9 89 89 CD cord-005453-4057qib7 8483 10 % % NN cord-005453-4057qib7 8483 11 ( ( -LRB- cord-005453-4057qib7 8483 12 95 95 CD cord-005453-4057qib7 8483 13 % % NN cord-005453-4057qib7 8483 14 CI CI NNP cord-005453-4057qib7 8483 15 , , , cord-005453-4057qib7 8483 16 67 67 CD cord-005453-4057qib7 8483 17 - - SYM cord-005453-4057qib7 8483 18 95 95 CD cord-005453-4057qib7 8483 19 % % NN cord-005453-4057qib7 8483 20 ) ) -RRB- cord-005453-4057qib7 8483 21 ( ( -LRB- cord-005453-4057qib7 8483 22 Figure figure NN cord-005453-4057qib7 8483 23 1 1 CD cord-005453-4057qib7 8483 24 ) ) -RRB- cord-005453-4057qib7 8483 25 . . . cord-005453-4057qib7 8484 1 Analysis analysis NN cord-005453-4057qib7 8484 2 by by IN cord-005453-4057qib7 8484 3 age age NN cord-005453-4057qib7 8484 4 at at IN cord-005453-4057qib7 8484 5 transplant transplant NN cord-005453-4057qib7 8484 6 revealed reveal VBD cord-005453-4057qib7 8484 7 a a DT cord-005453-4057qib7 8484 8 5-year 5-year CD cord-005453-4057qib7 8484 9 OS os NN cord-005453-4057qib7 8484 10 of of IN cord-005453-4057qib7 8484 11 100 100 CD cord-005453-4057qib7 8484 12 % % NN cord-005453-4057qib7 8484 13 for for IN cord-005453-4057qib7 8484 14 children child NNS cord-005453-4057qib7 8484 15 transplanted transplant VBN cord-005453-4057qib7 8484 16 at at IN cord-005453-4057qib7 8484 17 < < XX cord-005453-4057qib7 8484 18 = = SYM cord-005453-4057qib7 8484 19 5 5 CD cord-005453-4057qib7 8484 20 years year NNS cord-005453-4057qib7 8484 21 of of IN cord-005453-4057qib7 8484 22 age age NN cord-005453-4057qib7 8484 23 and and CC cord-005453-4057qib7 8484 24 81 81 CD cord-005453-4057qib7 8484 25 % % NN cord-005453-4057qib7 8484 26 ( ( -LRB- cord-005453-4057qib7 8484 27 95%CI 95%ci CD cord-005453-4057qib7 8484 28 , , , cord-005453-4057qib7 8484 29 60 60 CD cord-005453-4057qib7 8484 30 - - SYM cord-005453-4057qib7 8484 31 92 92 CD cord-005453-4057qib7 8484 32 % % NN cord-005453-4057qib7 8484 33 ) ) -RRB- cord-005453-4057qib7 8484 34 for for IN cord-005453-4057qib7 8484 35 the the DT cord-005453-4057qib7 8484 36 children child NNS cord-005453-4057qib7 8484 37 > > XX cord-005453-4057qib7 8484 38 5 5 CD cord-005453-4057qib7 8484 39 years year NNS cord-005453-4057qib7 8484 40 of of IN cord-005453-4057qib7 8484 41 age age NN cord-005453-4057qib7 8484 42 ( ( -LRB- cord-005453-4057qib7 8484 43 p p NN cord-005453-4057qib7 8484 44 < < XX cord-005453-4057qib7 8484 45 0.04 0.04 CD cord-005453-4057qib7 8484 46 ) ) -RRB- cord-005453-4057qib7 8485 1 ( ( -LRB- cord-005453-4057qib7 8485 2 Figure figure NN cord-005453-4057qib7 8485 3 2 2 CD cord-005453-4057qib7 8485 4 ) ) -RRB- cord-005453-4057qib7 8485 5 . . . cord-005453-4057qib7 8486 1 The the DT cord-005453-4057qib7 8486 2 OS OS NNP cord-005453-4057qib7 8486 3 was be VBD cord-005453-4057qib7 8486 4 comparable comparable JJ cord-005453-4057qib7 8486 5 between between IN cord-005453-4057qib7 8486 6 match match NN cord-005453-4057qib7 8486 7 family family NN cord-005453-4057qib7 8486 8 donor donor NN cord-005453-4057qib7 8486 9 ( ( -LRB- cord-005453-4057qib7 8486 10 88 88 CD cord-005453-4057qib7 8486 11 % % NN cord-005453-4057qib7 8486 12 , , , cord-005453-4057qib7 8486 13 95 95 CD cord-005453-4057qib7 8486 14 % % NN cord-005453-4057qib7 8486 15 CI ci NN cord-005453-4057qib7 8486 16 , , , cord-005453-4057qib7 8486 17 61 61 CD cord-005453-4057qib7 8486 18 - - SYM cord-005453-4057qib7 8486 19 97 97 CD cord-005453-4057qib7 8486 20 % % NN cord-005453-4057qib7 8486 21 ) ) -RRB- cord-005453-4057qib7 8486 22 and and CC cord-005453-4057qib7 8486 23 unrelated unrelated JJ cord-005453-4057qib7 8486 24 donor donor NN cord-005453-4057qib7 8486 25 transplant transplant NN cord-005453-4057qib7 8486 26 ( ( -LRB- cord-005453-4057qib7 8486 27 89 89 CD cord-005453-4057qib7 8486 28 % % NN cord-005453-4057qib7 8486 29 , , , cord-005453-4057qib7 8486 30 71 71 CD cord-005453-4057qib7 8486 31 - - SYM cord-005453-4057qib7 8486 32 95 95 CD cord-005453-4057qib7 8486 33 % % NN cord-005453-4057qib7 8486 34 ) ) -RRB- cord-005453-4057qib7 8487 1 ( ( -LRB- cord-005453-4057qib7 8487 2 Figure figure NN cord-005453-4057qib7 8487 3 3 3 CD cord-005453-4057qib7 8487 4 ) ) -RRB- cord-005453-4057qib7 8487 5 . . . cord-005453-4057qib7 8488 1 All all DT cord-005453-4057qib7 8488 2 four four CD cord-005453-4057qib7 8488 3 haploidentical haploidentical JJ cord-005453-4057qib7 8488 4 transplants transplant NNS cord-005453-4057qib7 8488 5 were be VBD cord-005453-4057qib7 8488 6 successful successful JJ cord-005453-4057qib7 8488 7 . . . cord-005453-4057qib7 8489 1 The the DT cord-005453-4057qib7 8489 2 5-year 5-year CD cord-005453-4057qib7 8489 3 ES es NN cord-005453-4057qib7 8489 4 for for IN cord-005453-4057qib7 8489 5 the the DT cord-005453-4057qib7 8489 6 entire entire JJ cord-005453-4057qib7 8489 7 cohort cohort NN cord-005453-4057qib7 8489 8 was be VBD cord-005453-4057qib7 8489 9 77 77 CD cord-005453-4057qib7 8489 10 % % NN cord-005453-4057qib7 8489 11 ( ( -LRB- cord-005453-4057qib7 8489 12 95 95 CD cord-005453-4057qib7 8489 13 % % NN cord-005453-4057qib7 8489 14 CI CI NNP cord-005453-4057qib7 8489 15 62 62 CD cord-005453-4057qib7 8489 16 - - SYM cord-005453-4057qib7 8489 17 87 87 CD cord-005453-4057qib7 8489 18 % % NN cord-005453-4057qib7 8489 19 ) ) -RRB- cord-005453-4057qib7 8489 20 . . . cord-005453-4057qib7 8490 1 None none NN cord-005453-4057qib7 8490 2 of of IN cord-005453-4057qib7 8490 3 the the DT cord-005453-4057qib7 8490 4 variables variable NNS cord-005453-4057qib7 8490 5 was be VBD cord-005453-4057qib7 8490 6 associated associate VBN cord-005453-4057qib7 8490 7 with with IN cord-005453-4057qib7 8490 8 ES ES NNP cord-005453-4057qib7 8490 9 . . . cord-005453-4057qib7 8491 1 All all DT cord-005453-4057qib7 8491 2 seven seven CD cord-005453-4057qib7 8491 3 patients patient NNS cord-005453-4057qib7 8491 4 with with IN cord-005453-4057qib7 8491 5 slipping slip VBG cord-005453-4057qib7 8491 6 chimerism chimerism NN cord-005453-4057qib7 8491 7 received receive VBD cord-005453-4057qib7 8491 8 a a DT cord-005453-4057qib7 8491 9 successful successful JJ cord-005453-4057qib7 8491 10 second second JJ cord-005453-4057qib7 8491 11 transplant transplant NN cord-005453-4057qib7 8491 12 . . . cord-005453-4057qib7 8492 1 The the DT cord-005453-4057qib7 8492 2 five five CD cord-005453-4057qib7 8492 3 deaths death NNS cord-005453-4057qib7 8492 4 were be VBD cord-005453-4057qib7 8492 5 all all RB cord-005453-4057qib7 8492 6 due due JJ cord-005453-4057qib7 8492 7 to to IN cord-005453-4057qib7 8492 8 transplantrelated transplantrelate VBN cord-005453-4057qib7 8492 9 complications complication NNS cord-005453-4057qib7 8492 10 ( ( -LRB- cord-005453-4057qib7 8492 11 2 2 CD cord-005453-4057qib7 8492 12 multi multi JJ cord-005453-4057qib7 8492 13 - - JJ cord-005453-4057qib7 8492 14 organ organ JJ cord-005453-4057qib7 8492 15 failures failure NNS cord-005453-4057qib7 8492 16 ; ; : cord-005453-4057qib7 8492 17 1 1 CD cord-005453-4057qib7 8492 18 pulmonary pulmonary JJ cord-005453-4057qib7 8492 19 haemorrhage haemorrhage NN cord-005453-4057qib7 8492 20 ; ; : cord-005453-4057qib7 8492 21 1 1 CD cord-005453-4057qib7 8492 22 graft graft NN cord-005453-4057qib7 8492 23 IV IV NNP cord-005453-4057qib7 8492 24 acute acute JJ cord-005453-4057qib7 8492 25 GvHD GvHD NNP cord-005453-4057qib7 8492 26 ; ; : cord-005453-4057qib7 8492 27 1 1 CD cord-005453-4057qib7 8492 28 post post JJ cord-005453-4057qib7 8492 29 - - JJ cord-005453-4057qib7 8492 30 transplant transplant JJ cord-005453-4057qib7 8492 31 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 8492 32 disease disease NN cord-005453-4057qib7 8492 33 ) ) -RRB- cord-005453-4057qib7 8492 34 . . . cord-005453-4057qib7 8493 1 The the DT cord-005453-4057qib7 8493 2 median median JJ cord-005453-4057qib7 8493 3 age age NN cord-005453-4057qib7 8493 4 at at IN cord-005453-4057qib7 8493 5 transplant transplant NN cord-005453-4057qib7 8493 6 of of IN cord-005453-4057qib7 8493 7 deceased deceased JJ cord-005453-4057qib7 8493 8 patients patient NNS cord-005453-4057qib7 8493 9 was be VBD cord-005453-4057qib7 8493 10 10.0 10.0 CD cord-005453-4057qib7 8493 11 years year NNS cord-005453-4057qib7 8494 1 ( ( -LRB- cord-005453-4057qib7 8494 2 range range VBP cord-005453-4057qib7 8494 3 8.4 8.4 CD cord-005453-4057qib7 8494 4 to to TO cord-005453-4057qib7 8494 5 18 18 CD cord-005453-4057qib7 8494 6 years year NNS cord-005453-4057qib7 8494 7 ) ) -RRB- cord-005453-4057qib7 8494 8 . . . cord-005453-4057qib7 8495 1 The the DT cord-005453-4057qib7 8495 2 1-year 1-year CD cord-005453-4057qib7 8495 3 and and CC cord-005453-4057qib7 8495 4 5-year 5-year CD cord-005453-4057qib7 8495 5 cumulative cumulative JJ cord-005453-4057qib7 8495 6 incidence incidence NN cord-005453-4057qib7 8495 7 of of IN cord-005453-4057qib7 8495 8 autoimmune autoimmune JJ cord-005453-4057qib7 8495 9 diseases disease NNS cord-005453-4057qib7 8495 10 were be VBD cord-005453-4057qib7 8495 11 9 9 CD cord-005453-4057qib7 8495 12 % % NN cord-005453-4057qib7 8495 13 and and CC cord-005453-4057qib7 8495 14 12 12 CD cord-005453-4057qib7 8495 15 % % NN cord-005453-4057qib7 8495 16 respectively respectively RB cord-005453-4057qib7 8495 17 . . . cord-005453-4057qib7 8496 1 Three three CD cord-005453-4057qib7 8496 2 ( ( -LRB- cord-005453-4057qib7 8496 3 5 5 CD cord-005453-4057qib7 8496 4 % % NN cord-005453-4057qib7 8496 5 ) ) -RRB- cord-005453-4057qib7 8496 6 had have VBD cord-005453-4057qib7 8496 7 immune immune JJ cord-005453-4057qib7 8496 8 cytopenia cytopenia NNS cord-005453-4057qib7 8496 9 while while IN cord-005453-4057qib7 8496 10 3 3 CD cord-005453-4057qib7 8496 11 ( ( -LRB- cord-005453-4057qib7 8496 12 5 5 CD cord-005453-4057qib7 8496 13 % % NN cord-005453-4057qib7 8496 14 ) ) -RRB- cord-005453-4057qib7 8496 15 had have VBD cord-005453-4057qib7 8496 16 autoimmune autoimmune JJ cord-005453-4057qib7 8496 17 endocrinopathy endocrinopathy NNP cord-005453-4057qib7 8496 18 ( ( -LRB- cord-005453-4057qib7 8496 19 2 2 CD cord-005453-4057qib7 8496 20 thyroid thyroid NN cord-005453-4057qib7 8496 21 dysfunction dysfunction NN cord-005453-4057qib7 8496 22 ; ; : cord-005453-4057qib7 8496 23 1 1 CD cord-005453-4057qib7 8496 24 type type NN cord-005453-4057qib7 8496 25 1 1 CD cord-005453-4057qib7 8496 26 diabetes diabetes NN cord-005453-4057qib7 8496 27 mellitus mellitus NN cord-005453-4057qib7 8496 28 ) ) -RRB- cord-005453-4057qib7 8496 29 . . . cord-005453-4057qib7 8497 1 The the DT cord-005453-4057qib7 8497 2 median median JJ cord-005453-4057qib7 8497 3 age age NN cord-005453-4057qib7 8497 4 of of IN cord-005453-4057qib7 8497 5 long long JJ cord-005453-4057qib7 8497 6 - - HYPH cord-005453-4057qib7 8497 7 term term NN cord-005453-4057qib7 8497 8 survivors survivor NNS cord-005453-4057qib7 8497 9 was be VBD cord-005453-4057qib7 8497 10 14 14 CD cord-005453-4057qib7 8497 11 years year NNS cord-005453-4057qib7 8497 12 ( ( -LRB- cord-005453-4057qib7 8497 13 range range NN cord-005453-4057qib7 8497 14 , , , cord-005453-4057qib7 8497 15 2 2 CD cord-005453-4057qib7 8497 16 to to TO cord-005453-4057qib7 8497 17 36 36 CD cord-005453-4057qib7 8497 18 years year NNS cord-005453-4057qib7 8497 19 ) ) -RRB- cord-005453-4057qib7 8497 20 with with IN cord-005453-4057qib7 8497 21 the the DT cord-005453-4057qib7 8497 22 median median JJ cord-005453-4057qib7 8497 23 duration duration NN cord-005453-4057qib7 8497 24 of of IN cord-005453-4057qib7 8497 25 follow follow NN cord-005453-4057qib7 8497 26 - - HYPH cord-005453-4057qib7 8497 27 up up NN cord-005453-4057qib7 8497 28 of of IN cord-005453-4057qib7 8497 29 6.5 6.5 CD cord-005453-4057qib7 8497 30 years year NNS cord-005453-4057qib7 8497 31 ( ( -LRB- cord-005453-4057qib7 8497 32 range range NN cord-005453-4057qib7 8497 33 , , , cord-005453-4057qib7 8497 34 0.32 0.32 CD cord-005453-4057qib7 8497 35 to to IN cord-005453-4057qib7 8497 36 19.5 19.5 CD cord-005453-4057qib7 8497 37 years year NNS cord-005453-4057qib7 8497 38 ) ) -RRB- cord-005453-4057qib7 8497 39 . . . cord-005453-4057qib7 8498 1 There there EX cord-005453-4057qib7 8498 2 was be VBD cord-005453-4057qib7 8498 3 no no DT cord-005453-4057qib7 8498 4 late late JJ cord-005453-4057qib7 8498 5 death death NN cord-005453-4057qib7 8498 6 in in IN cord-005453-4057qib7 8498 7 the the DT cord-005453-4057qib7 8498 8 entire entire JJ cord-005453-4057qib7 8498 9 cohort cohort NN cord-005453-4057qib7 8498 10 . . . cord-005453-4057qib7 8499 1 The the DT cord-005453-4057qib7 8499 2 median median JJ cord-005453-4057qib7 8499 3 donor donor NN cord-005453-4057qib7 8499 4 myeloid myeloid NN cord-005453-4057qib7 8499 5 chimerism chimerism NN cord-005453-4057qib7 8499 6 was be VBD cord-005453-4057qib7 8499 7 100 100 CD cord-005453-4057qib7 8499 8 % % NN cord-005453-4057qib7 8499 9 ( ( -LRB- cord-005453-4057qib7 8499 10 range range NN cord-005453-4057qib7 8499 11 23 23 CD cord-005453-4057qib7 8499 12 to to IN cord-005453-4057qib7 8499 13 100 100 CD cord-005453-4057qib7 8499 14 % % NN cord-005453-4057qib7 8499 15 ) ) -RRB- cord-005453-4057qib7 8500 1 Conclusions conclusion NNS cord-005453-4057qib7 8500 2 : : : cord-005453-4057qib7 8501 1 Despite despite IN cord-005453-4057qib7 8501 2 the the DT cord-005453-4057qib7 8501 3 limitations limitation NNS cord-005453-4057qib7 8501 4 of of IN cord-005453-4057qib7 8501 5 a a DT cord-005453-4057qib7 8501 6 single single JJ cord-005453-4057qib7 8501 7 centre centre NN cord-005453-4057qib7 8501 8 study study NN cord-005453-4057qib7 8501 9 , , , cord-005453-4057qib7 8501 10 our -PRON- PRP$ cord-005453-4057qib7 8501 11 findings finding NNS cord-005453-4057qib7 8501 12 confirm confirm VBP cord-005453-4057qib7 8501 13 that that IN cord-005453-4057qib7 8501 14 HSCT HSCT NNP cord-005453-4057qib7 8501 15 is be VBZ cord-005453-4057qib7 8501 16 a a DT cord-005453-4057qib7 8501 17 safe safe JJ cord-005453-4057qib7 8501 18 and and CC cord-005453-4057qib7 8501 19 longlasting longlasting JJ cord-005453-4057qib7 8501 20 curative curative JJ cord-005453-4057qib7 8501 21 therapy therapy NN cord-005453-4057qib7 8501 22 for for IN cord-005453-4057qib7 8501 23 children child NNS cord-005453-4057qib7 8501 24 with with IN cord-005453-4057qib7 8501 25 CGD CGD NNP cord-005453-4057qib7 8501 26 Disclosure Disclosure NNP cord-005453-4057qib7 8501 27 : : : cord-005453-4057qib7 8502 1 None none NN cord-005453-4057qib7 8503 1 Non non JJ cord-005453-4057qib7 8503 2 -medical -medical JJ cord-005453-4057qib7 8503 3 challenges challenge NNS cord-005453-4057qib7 8503 4 in in IN cord-005453-4057qib7 8503 5 the the DT cord-005453-4057qib7 8503 6 diagnosis diagnosis NN cord-005453-4057qib7 8503 7 and and CC cord-005453-4057qib7 8503 8 transplantation transplantation NN cord-005453-4057qib7 8503 9 of of IN cord-005453-4057qib7 8503 10 patients patient NNS cord-005453-4057qib7 8503 11 with with IN cord-005453-4057qib7 8503 12 primary primary JJ cord-005453-4057qib7 8503 13 immune immune JJ cord-005453-4057qib7 8503 14 deficiency deficiency NN cord-005453-4057qib7 8503 15 : : : cord-005453-4057qib7 8503 16 An an DT cord-005453-4057qib7 8503 17 experience experience NN cord-005453-4057qib7 8503 18 from from IN cord-005453-4057qib7 8503 19 a a DT cord-005453-4057qib7 8503 20 tertiary tertiary JJ cord-005453-4057qib7 8503 21 care care NN cord-005453-4057qib7 8503 22 center center NN cord-005453-4057qib7 8503 23 in in IN cord-005453-4057qib7 8503 24 India India NNP cord-005453-4057qib7 8503 25 Sagar Sagar NNP cord-005453-4057qib7 8503 26 Bhattad Bhattad NNP cord-005453-4057qib7 8503 27 1 1 CD cord-005453-4057qib7 8503 28 , , , cord-005453-4057qib7 8503 29 Stalin Stalin NNP cord-005453-4057qib7 8503 30 Ramprakash Ramprakash NNP cord-005453-4057qib7 8503 31 1 1 CD cord-005453-4057qib7 8503 32 , , , cord-005453-4057qib7 8503 33 Raghuram Raghuram NNP cord-005453-4057qib7 8503 34 CP CP NNP cord-005453-4057qib7 8503 35 1 1 CD cord-005453-4057qib7 8503 36 , , , cord-005453-4057qib7 8503 37 Chetan Chetan NNP cord-005453-4057qib7 8503 38 Ginigeri Ginigeri NNP cord-005453-4057qib7 8503 39 1 1 CD cord-005453-4057qib7 8503 40 , , , cord-005453-4057qib7 8503 41 Fulvio Fulvio NNP cord-005453-4057qib7 8503 42 Porta Porta NNP cord-005453-4057qib7 8503 43 1,2 1,2 CD cord-005453-4057qib7 8503 44 Background background NN cord-005453-4057qib7 8503 45 : : : cord-005453-4057qib7 8503 46 Primary primary JJ cord-005453-4057qib7 8503 47 Immune Immune NNP cord-005453-4057qib7 8503 48 Deficiencies Deficiencies NNPS cord-005453-4057qib7 8503 49 ( ( -LRB- cord-005453-4057qib7 8503 50 PID PID NNP cord-005453-4057qib7 8503 51 ) ) -RRB- cord-005453-4057qib7 8503 52 are be VBP cord-005453-4057qib7 8503 53 increasingly increasingly RB cord-005453-4057qib7 8503 54 being be VBG cord-005453-4057qib7 8503 55 recognized recognize VBN cord-005453-4057qib7 8503 56 in in IN cord-005453-4057qib7 8503 57 several several JJ cord-005453-4057qib7 8503 58 parts part NNS cord-005453-4057qib7 8503 59 of of IN cord-005453-4057qib7 8503 60 India India NNP cord-005453-4057qib7 8503 61 . . . cord-005453-4057qib7 8504 1 Despite despite IN cord-005453-4057qib7 8504 2 being be VBG cord-005453-4057qib7 8504 3 diagnosed diagnose VBN cord-005453-4057qib7 8504 4 , , , cord-005453-4057qib7 8504 5 many many JJ cord-005453-4057qib7 8504 6 patients patient NNS cord-005453-4057qib7 8504 7 fail fail VBP cord-005453-4057qib7 8504 8 to to TO cord-005453-4057qib7 8504 9 receive receive VB cord-005453-4057qib7 8504 10 optimal optimal JJ cord-005453-4057qib7 8504 11 care care NN cord-005453-4057qib7 8504 12 due due IN cord-005453-4057qib7 8504 13 to to IN cord-005453-4057qib7 8504 14 financial financial JJ cord-005453-4057qib7 8504 15 and and CC cord-005453-4057qib7 8504 16 social social JJ cord-005453-4057qib7 8504 17 constraints constraint NNS cord-005453-4057qib7 8504 18 . . . cord-005453-4057qib7 8505 1 Methods method NNS cord-005453-4057qib7 8505 2 : : : cord-005453-4057qib7 8506 1 Case case NN cord-005453-4057qib7 8506 2 records record NNS cord-005453-4057qib7 8506 3 of of IN cord-005453-4057qib7 8506 4 patients patient NNS cord-005453-4057qib7 8506 5 diagnosed diagnose VBN cord-005453-4057qib7 8506 6 and and CC cord-005453-4057qib7 8506 7 treated treat VBN cord-005453-4057qib7 8506 8 ( ( -LRB- cord-005453-4057qib7 8506 9 including include VBG cord-005453-4057qib7 8506 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 8506 11 stem stem NN cord-005453-4057qib7 8506 12 cell cell NN cord-005453-4057qib7 8506 13 transplants transplant NNS cord-005453-4057qib7 8506 14 ) ) -RRB- cord-005453-4057qib7 8506 15 for for IN cord-005453-4057qib7 8506 16 PID pid NN cord-005453-4057qib7 8506 17 diseases disease NNS cord-005453-4057qib7 8506 18 during during IN cord-005453-4057qib7 8506 19 Feb Feb NNP cord-005453-4057qib7 8506 20 2018 2018 CD cord-005453-4057qib7 8506 21 -Nov -nov CD cord-005453-4057qib7 8506 22 2019 2019 CD cord-005453-4057qib7 8506 23 at at IN cord-005453-4057qib7 8506 24 Aster Aster NNP cord-005453-4057qib7 8506 25 CMI CMI NNP cord-005453-4057qib7 8506 26 Hospital Hospital NNP cord-005453-4057qib7 8506 27 , , , cord-005453-4057qib7 8506 28 Bangalore Bangalore NNP cord-005453-4057qib7 8506 29 , , , cord-005453-4057qib7 8506 30 India India NNP cord-005453-4057qib7 8506 31 were be VBD cord-005453-4057qib7 8506 32 analysed analyse VBN cord-005453-4057qib7 8506 33 . . . cord-005453-4057qib7 8507 1 Factors factor NNS cord-005453-4057qib7 8507 2 leading lead VBG cord-005453-4057qib7 8507 3 to to IN cord-005453-4057qib7 8507 4 deferred deferred JJ cord-005453-4057qib7 8507 5 or or CC cord-005453-4057qib7 8507 6 suboptimal suboptimal JJ cord-005453-4057qib7 8507 7 care care NN cord-005453-4057qib7 8507 8 were be VBD cord-005453-4057qib7 8507 9 assessed assess VBN cord-005453-4057qib7 8507 10 in in IN cord-005453-4057qib7 8507 11 detail detail NN cord-005453-4057qib7 8507 12 . . . cord-005453-4057qib7 8508 1 Results result NNS cord-005453-4057qib7 8508 2 : : : cord-005453-4057qib7 8509 1 65 65 CD cord-005453-4057qib7 8509 2 patients patient NNS cord-005453-4057qib7 8509 3 with with IN cord-005453-4057qib7 8509 4 various various JJ cord-005453-4057qib7 8509 5 PIDs pid NNS cord-005453-4057qib7 8509 6 were be VBD cord-005453-4057qib7 8509 7 diagnosed diagnose VBN cord-005453-4057qib7 8509 8 during during IN cord-005453-4057qib7 8509 9 the the DT cord-005453-4057qib7 8509 10 study study NN cord-005453-4057qib7 8509 11 period period NN cord-005453-4057qib7 8509 12 ( ( -LRB- cord-005453-4057qib7 8509 13 details detail NNS cord-005453-4057qib7 8509 14 in in IN cord-005453-4057qib7 8509 15 table table NN cord-005453-4057qib7 8509 16 ) ) -RRB- cord-005453-4057qib7 8509 17 . . . cord-005453-4057qib7 8510 1 35 35 CD cord-005453-4057qib7 8510 2 of of IN cord-005453-4057qib7 8510 3 them -PRON- PRP cord-005453-4057qib7 8510 4 warranted warrant VBD cord-005453-4057qib7 8510 5 a a DT cord-005453-4057qib7 8510 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 8510 7 stem stem NN cord-005453-4057qib7 8510 8 cell cell NN cord-005453-4057qib7 8510 9 transplant transplant NN cord-005453-4057qib7 8510 10 ( ( -LRB- cord-005453-4057qib7 8510 11 HSCT HSCT NNP cord-005453-4057qib7 8510 12 ) ) -RRB- cord-005453-4057qib7 8510 13 as as IN cord-005453-4057qib7 8510 14 definitive definitive JJ cord-005453-4057qib7 8510 15 curative curative JJ cord-005453-4057qib7 8510 16 treatment treatment NN cord-005453-4057qib7 8510 17 . . . cord-005453-4057qib7 8511 1 A a DT cord-005453-4057qib7 8511 2 total total NN cord-005453-4057qib7 8511 3 of of IN cord-005453-4057qib7 8511 4 7 7 CD cord-005453-4057qib7 8511 5 children child NNS cord-005453-4057qib7 8511 6 received receive VBD cord-005453-4057qib7 8511 7 9 9 CD cord-005453-4057qib7 8511 8 HSCT HSCT NNP cord-005453-4057qib7 8511 9 . . . cord-005453-4057qib7 8512 1 2 2 CD cord-005453-4057qib7 8512 2 of of IN cord-005453-4057qib7 8512 3 them -PRON- PRP cord-005453-4057qib7 8512 4 died die VBD cord-005453-4057qib7 8512 5 while while IN cord-005453-4057qib7 8512 6 5 5 CD cord-005453-4057qib7 8512 7 of of IN cord-005453-4057qib7 8512 8 them -PRON- PRP cord-005453-4057qib7 8512 9 are be VBP cord-005453-4057qib7 8512 10 alive alive JJ cord-005453-4057qib7 8512 11 and and CC cord-005453-4057qib7 8512 12 well well RB cord-005453-4057qib7 8512 13 . . . cord-005453-4057qib7 8513 1 17 17 CD cord-005453-4057qib7 8513 2 children child NNS cord-005453-4057qib7 8513 3 ( ( -LRB- cord-005453-4057qib7 8513 4 13 13 CD cord-005453-4057qib7 8513 5 with with IN cord-005453-4057qib7 8513 6 Severe severe JJ cord-005453-4057qib7 8513 7 Combined Combined NNP cord-005453-4057qib7 8513 8 Immune Immune NNP cord-005453-4057qib7 8513 9 Deficiency deficiency NN cord-005453-4057qib7 8513 10 ) ) -RRB- cord-005453-4057qib7 8513 11 died die VBD cord-005453-4057qib7 8513 12 before before IN cord-005453-4057qib7 8513 13 a a DT cord-005453-4057qib7 8513 14 HSCT HSCT NNP cord-005453-4057qib7 8513 15 could could MD cord-005453-4057qib7 8513 16 be be VB cord-005453-4057qib7 8513 17 carried carry VBN cord-005453-4057qib7 8513 18 out out RP cord-005453-4057qib7 8513 19 . . . cord-005453-4057qib7 8514 1 12 12 CD cord-005453-4057qib7 8514 2 of of IN cord-005453-4057qib7 8514 3 them -PRON- PRP cord-005453-4057qib7 8514 4 were be VBD cord-005453-4057qib7 8514 5 critically critically RB cord-005453-4057qib7 8514 6 ill ill JJ cord-005453-4057qib7 8514 7 at at IN cord-005453-4057qib7 8514 8 presentation presentation NN cord-005453-4057qib7 8514 9 , , , cord-005453-4057qib7 8514 10 while while IN cord-005453-4057qib7 8514 11 5 5 CD cord-005453-4057qib7 8514 12 were be VBD cord-005453-4057qib7 8514 13 stable stable JJ cord-005453-4057qib7 8514 14 but but CC cord-005453-4057qib7 8514 15 deferred deferred JJ cord-005453-4057qib7 8514 16 further further JJ cord-005453-4057qib7 8514 17 treatment treatment NN cord-005453-4057qib7 8514 18 citing cite VBG cord-005453-4057qib7 8514 19 financial financial JJ cord-005453-4057qib7 8514 20 and and CC cord-005453-4057qib7 8514 21 social social JJ cord-005453-4057qib7 8514 22 constraints constraint NNS cord-005453-4057qib7 8514 23 . . . cord-005453-4057qib7 8515 1 11 11 CD cord-005453-4057qib7 8515 2 children child NNS cord-005453-4057qib7 8515 3 needing need VBG cord-005453-4057qib7 8515 4 transplant transplant NN cord-005453-4057qib7 8515 5 continue continue VBP cord-005453-4057qib7 8515 6 to to TO cord-005453-4057qib7 8515 7 remain remain VB cord-005453-4057qib7 8515 8 on on IN cord-005453-4057qib7 8515 9 follow follow NN cord-005453-4057qib7 8515 10 - - HYPH cord-005453-4057qib7 8515 11 up up NN cord-005453-4057qib7 8515 12 and and CC cord-005453-4057qib7 8515 13 have have VBP cord-005453-4057qib7 8515 14 not not RB cord-005453-4057qib7 8515 15 been be VBN cord-005453-4057qib7 8515 16 transplanted transplant VBN cord-005453-4057qib7 8515 17 to to IN cord-005453-4057qib7 8515 18 date date NN cord-005453-4057qib7 8515 19 ( ( -LRB- cord-005453-4057qib7 8515 20 4 4 CD cord-005453-4057qib7 8515 21 of of IN cord-005453-4057qib7 8515 22 them -PRON- PRP cord-005453-4057qib7 8515 23 have have VBP cord-005453-4057qib7 8515 24 significant significant JJ cord-005453-4057qib7 8515 25 financial financial JJ cord-005453-4057qib7 8515 26 constraints constraint NNS cord-005453-4057qib7 8515 27 , , , cord-005453-4057qib7 8515 28 3 3 CD cord-005453-4057qib7 8515 29 families family NNS cord-005453-4057qib7 8515 30 are be VBP cord-005453-4057qib7 8515 31 not not RB cord-005453-4057qib7 8515 32 convinced convince VBN cord-005453-4057qib7 8515 33 about about IN cord-005453-4057qib7 8515 34 the the DT cord-005453-4057qib7 8515 35 need need NN cord-005453-4057qib7 8515 36 for for IN cord-005453-4057qib7 8515 37 transplant transplant NN cord-005453-4057qib7 8515 38 and and CC cord-005453-4057qib7 8515 39 4 4 CD cord-005453-4057qib7 8515 40 of of IN cord-005453-4057qib7 8515 41 them -PRON- PRP cord-005453-4057qib7 8515 42 are be VBP cord-005453-4057qib7 8515 43 being be VBG cord-005453-4057qib7 8515 44 prepared prepare VBN cord-005453-4057qib7 8515 45 for for IN cord-005453-4057qib7 8515 46 transplant transplant NN cord-005453-4057qib7 8515 47 ) ) -RRB- cord-005453-4057qib7 8515 48 . . . cord-005453-4057qib7 8516 1 Table table NN cord-005453-4057qib7 8516 2 : : : cord-005453-4057qib7 8517 1 ( ( -LRB- cord-005453-4057qib7 8517 2 SCID SCID NNP cord-005453-4057qib7 8517 3 -Severe -severe RB cord-005453-4057qib7 8517 4 Combined Combined NNP cord-005453-4057qib7 8517 5 Immune Immune NNP cord-005453-4057qib7 8517 6 Deficiency deficiency NN cord-005453-4057qib7 8517 7 , , , cord-005453-4057qib7 8517 8 VODI VODI NNP cord-005453-4057qib7 8517 9 - - HYPH cord-005453-4057qib7 8517 10 Veno Veno NNP cord-005453-4057qib7 8517 11 - - HYPH cord-005453-4057qib7 8517 12 Occlusive Occlusive NNP cord-005453-4057qib7 8517 13 Disease Disease NNP cord-005453-4057qib7 8517 14 with with IN cord-005453-4057qib7 8517 15 Immunodeficiency Immunodeficiency NNP cord-005453-4057qib7 8517 16 , , , cord-005453-4057qib7 8517 17 CGD CGD NNP cord-005453-4057qib7 8517 18 -Chronic -chronic CC cord-005453-4057qib7 8517 19 granulomatous granulomatous JJ cord-005453-4057qib7 8517 20 disease disease NN cord-005453-4057qib7 8517 21 , , , cord-005453-4057qib7 8517 22 HLH HLH NNP cord-005453-4057qib7 8517 23 -Hemophagolymphohistiocytosis -Hemophagolymphohistiocytosis NNP cord-005453-4057qib7 8518 1 , , , cord-005453-4057qib7 8518 2 WAS be VBD cord-005453-4057qib7 8518 3 -Wiskott -Wiskott NNP cord-005453-4057qib7 8518 4 Aldrich Aldrich NNP cord-005453-4057qib7 8518 5 Syndrome Syndrome NNP cord-005453-4057qib7 8518 6 , , , cord-005453-4057qib7 8518 7 XLT XLT NNP cord-005453-4057qib7 8518 8 -X -X VBZ cord-005453-4057qib7 8518 9 linked link VBN cord-005453-4057qib7 8518 10 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 8518 11 , , , cord-005453-4057qib7 8518 12 LAD lad NN cord-005453-4057qib7 8518 13 - - HYPH cord-005453-4057qib7 8518 14 Leukocyte Leukocyte NNP cord-005453-4057qib7 8518 15 adhesion adhesion NN cord-005453-4057qib7 8518 16 deficiency deficiency NN cord-005453-4057qib7 8518 17 , , , cord-005453-4057qib7 8518 18 MSMD MSMD NNP cord-005453-4057qib7 8518 19 -Mendelian -Mendelian HYPH cord-005453-4057qib7 8518 20 Susceptibility Susceptibility NNP cord-005453-4057qib7 8518 21 to to IN cord-005453-4057qib7 8518 22 Mycobacterial Mycobacterial NNP cord-005453-4057qib7 8518 23 Disease Disease NNP cord-005453-4057qib7 8518 24 , , , cord-005453-4057qib7 8518 25 XLA XLA NNP cord-005453-4057qib7 8518 26 -X -X VBZ cord-005453-4057qib7 8518 27 linked link VBD cord-005453-4057qib7 8518 28 Agammaglobulinemia Agammaglobulinemia NNP cord-005453-4057qib7 8518 29 , , , cord-005453-4057qib7 8518 30 CVID CVID NNP cord-005453-4057qib7 8519 1 -Common -Common . cord-005453-4057qib7 8520 1 Variable variable JJ cord-005453-4057qib7 8520 2 Immune Immune NNP cord-005453-4057qib7 8520 3 Deficiency deficiency NN cord-005453-4057qib7 8520 4 , , , cord-005453-4057qib7 8520 5 APECED APECED NNP cord-005453-4057qib7 8520 6 -Autoimmune -Autoimmune NNP cord-005453-4057qib7 8521 1 Polyendocrinopathy Polyendocrinopathy NNP cord-005453-4057qib7 8522 1 Candidiasis Candidiasis NNP cord-005453-4057qib7 8522 2 Ectodermal Ectodermal NNP cord-005453-4057qib7 8522 3 Dystrophy Dystrophy NNP cord-005453-4057qib7 8522 4 , , , cord-005453-4057qib7 8522 5 CMCC CMCC NNP cord-005453-4057qib7 8522 6 -Chronic -Chronic . cord-005453-4057qib7 8523 1 MucoCutaneous MucoCutaneous NNP cord-005453-4057qib7 8523 2 Candidiasis Candidiasis NNP cord-005453-4057qib7 8523 3 , , , cord-005453-4057qib7 8524 1 AT at IN cord-005453-4057qib7 8524 2 -Ataxia -Ataxia : cord-005453-4057qib7 8524 3 telangiectasia telangiectasia NNP cord-005453-4057qib7 8524 4 ) ) -RRB- cord-005453-4057qib7 8524 5 . . . cord-005453-4057qib7 8525 1 Conclusions conclusion NNS cord-005453-4057qib7 8525 2 : : : cord-005453-4057qib7 8526 1 We -PRON- PRP cord-005453-4057qib7 8526 2 present present VBP cord-005453-4057qib7 8526 3 our -PRON- PRP$ cord-005453-4057qib7 8526 4 experience experience NN cord-005453-4057qib7 8526 5 from from IN cord-005453-4057qib7 8526 6 a a DT cord-005453-4057qib7 8526 7 developing develop VBG cord-005453-4057qib7 8526 8 country country NN cord-005453-4057qib7 8526 9 and and CC cord-005453-4057qib7 8526 10 discuss discuss VB cord-005453-4057qib7 8526 11 non non JJ cord-005453-4057qib7 8526 12 - - JJ cord-005453-4057qib7 8526 13 medical medical JJ cord-005453-4057qib7 8526 14 factors factor NNS cord-005453-4057qib7 8526 15 leading lead VBG cord-005453-4057qib7 8526 16 to to IN cord-005453-4057qib7 8526 17 suboptimal suboptimal JJ cord-005453-4057qib7 8526 18 care care NN cord-005453-4057qib7 8526 19 in in IN cord-005453-4057qib7 8526 20 children child NNS cord-005453-4057qib7 8526 21 with with IN cord-005453-4057qib7 8526 22 PID PID NNP cord-005453-4057qib7 8526 23 . . . cord-005453-4057qib7 8527 1 Only only RB cord-005453-4057qib7 8527 2 20 20 CD cord-005453-4057qib7 8527 3 % % NN cord-005453-4057qib7 8527 4 children child NNS cord-005453-4057qib7 8527 5 warranting warrant VBG cord-005453-4057qib7 8527 6 HSCT HSCT NNP cord-005453-4057qib7 8527 7 could could MD cord-005453-4057qib7 8527 8 be be VB cord-005453-4057qib7 8527 9 transplanted transplant VBN cord-005453-4057qib7 8527 10 in in IN cord-005453-4057qib7 8527 11 our -PRON- PRP$ cord-005453-4057qib7 8527 12 cohort cohort NN cord-005453-4057qib7 8527 13 . . . cord-005453-4057qib7 8528 1 Among among IN cord-005453-4057qib7 8528 2 those those DT cord-005453-4057qib7 8528 3 where where WRB cord-005453-4057qib7 8528 4 HSCT HSCT NNP cord-005453-4057qib7 8528 5 is be VBZ cord-005453-4057qib7 8528 6 potentially potentially RB cord-005453-4057qib7 8528 7 curative curative JJ cord-005453-4057qib7 8528 8 48 48 CD cord-005453-4057qib7 8528 9 % % NN cord-005453-4057qib7 8528 10 of of IN cord-005453-4057qib7 8528 11 children child NNS cord-005453-4057qib7 8528 12 died die VBD cord-005453-4057qib7 8528 13 before before IN cord-005453-4057qib7 8528 14 HSCT HSCT NNP cord-005453-4057qib7 8528 15 could could MD cord-005453-4057qib7 8528 16 be be VB cord-005453-4057qib7 8528 17 offered offer VBN cord-005453-4057qib7 8528 18 . . . cord-005453-4057qib7 8529 1 Transplants transplant NNS cord-005453-4057qib7 8529 2 in in IN cord-005453-4057qib7 8529 3 developing develop VBG cord-005453-4057qib7 8529 4 countries country NNS cord-005453-4057qib7 8529 5 pose pose VBP cord-005453-4057qib7 8529 6 unique unique JJ cord-005453-4057qib7 8529 7 challenges challenge NNS cord-005453-4057qib7 8529 8 due due JJ cord-005453-4057qib7 8529 9 to to IN cord-005453-4057qib7 8529 10 the the DT cord-005453-4057qib7 8529 11 absence absence NN cord-005453-4057qib7 8529 12 of of IN cord-005453-4057qib7 8529 13 government government NN cord-005453-4057qib7 8529 14 funding funding NN cord-005453-4057qib7 8529 15 and/or and/or CC cord-005453-4057qib7 8529 16 universal universal JJ cord-005453-4057qib7 8529 17 insurance insurance NN cord-005453-4057qib7 8529 18 coverage coverage NN cord-005453-4057qib7 8529 19 . . . cord-005453-4057qib7 8530 1 In in IN cord-005453-4057qib7 8530 2 addition addition NN cord-005453-4057qib7 8530 3 to to TO cord-005453-4057qib7 8530 4 delay delay VB cord-005453-4057qib7 8530 5 in in IN cord-005453-4057qib7 8530 6 diagnosis diagnosis NN cord-005453-4057qib7 8530 7 and and CC cord-005453-4057qib7 8530 8 critical critical JJ cord-005453-4057qib7 8530 9 state state NN cord-005453-4057qib7 8530 10 of of IN cord-005453-4057qib7 8530 11 patients patient NNS cord-005453-4057qib7 8530 12 at at IN cord-005453-4057qib7 8530 13 admission admission NN cord-005453-4057qib7 8530 14 , , , cord-005453-4057qib7 8530 15 financial financial JJ cord-005453-4057qib7 8530 16 and and CC cord-005453-4057qib7 8530 17 social social JJ cord-005453-4057qib7 8530 18 factors factor NNS cord-005453-4057qib7 8530 19 significantly significantly RB cord-005453-4057qib7 8530 20 contributed contribute VBD cord-005453-4057qib7 8530 21 to to IN cord-005453-4057qib7 8530 22 poor poor JJ cord-005453-4057qib7 8530 23 outcome outcome NN cord-005453-4057qib7 8530 24 . . . cord-005453-4057qib7 8531 1 Disclosure disclosure NN cord-005453-4057qib7 8531 2 : : : cord-005453-4057qib7 8532 1 None none NN cord-005453-4057qib7 8533 1 The the DT cord-005453-4057qib7 8533 2 outcome outcome NN cord-005453-4057qib7 8533 3 of of IN cord-005453-4057qib7 8533 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 8533 5 stem stem NN cord-005453-4057qib7 8533 6 cell cell NN cord-005453-4057qib7 8533 7 transplantation transplantation NN cord-005453-4057qib7 8533 8 ( ( -LRB- cord-005453-4057qib7 8533 9 HSCT HSCT NNP cord-005453-4057qib7 8533 10 ) ) -RRB- cord-005453-4057qib7 8533 11 in in IN cord-005453-4057qib7 8533 12 pediatric pediatric JJ cord-005453-4057qib7 8533 13 patients patient NNS cord-005453-4057qib7 8533 14 with with IN cord-005453-4057qib7 8533 15 hemophagocytic hemophagocytic JJ cord-005453-4057qib7 8533 16 lymphohistiocytosis lymphohistiocytosis NN cord-005453-4057qib7 8533 17 ( ( -LRB- cord-005453-4057qib7 8533 18 HLH HLH NNP cord-005453-4057qib7 8533 19 ) ) -RRB- cord-005453-4057qib7 8533 20 in in IN cord-005453-4057qib7 8533 21 Korea Korea NNP cord-005453-4057qib7 8533 22 Methods Methods NNPS cord-005453-4057qib7 8533 23 : : : cord-005453-4057qib7 8534 1 The the DT cord-005453-4057qib7 8534 2 Korea Korea NNP cord-005453-4057qib7 8534 3 Histiocytosis Histiocytosis NNP cord-005453-4057qib7 8534 4 Working Working NNP cord-005453-4057qib7 8534 5 Party Party NNP cord-005453-4057qib7 8534 6 retrospectively retrospectively RB cord-005453-4057qib7 8534 7 collected collect VBD cord-005453-4057qib7 8534 8 nation nation NN cord-005453-4057qib7 8534 9 - - HYPH cord-005453-4057qib7 8534 10 wide wide JJ cord-005453-4057qib7 8534 11 data datum NNS cord-005453-4057qib7 8534 12 from from IN cord-005453-4057qib7 8534 13 the the DT cord-005453-4057qib7 8534 14 patients patient NNS cord-005453-4057qib7 8534 15 diagnosed diagnose VBN cord-005453-4057qib7 8534 16 with with IN cord-005453-4057qib7 8534 17 HLH HLH NNP cord-005453-4057qib7 8534 18 and and CC cord-005453-4057qib7 8534 19 underwent undergo VBD cord-005453-4057qib7 8534 20 allogeneic allogeneic JJ cord-005453-4057qib7 8534 21 HSCT HSCT NNP cord-005453-4057qib7 8534 22 between between IN cord-005453-4057qib7 8534 23 2009 2009 CD cord-005453-4057qib7 8534 24 and and CC cord-005453-4057qib7 8534 25 2017 2017 CD cord-005453-4057qib7 8534 26 . . . cord-005453-4057qib7 8535 1 The the DT cord-005453-4057qib7 8535 2 clinical clinical JJ cord-005453-4057qib7 8535 3 characteristics characteristic NNS cord-005453-4057qib7 8535 4 and and CC cord-005453-4057qib7 8535 5 treatment treatment NN cord-005453-4057qib7 8535 6 outcomes outcome NNS cord-005453-4057qib7 8535 7 of of IN cord-005453-4057qib7 8535 8 the the DT cord-005453-4057qib7 8535 9 patients patient NNS cord-005453-4057qib7 8535 10 were be VBD cord-005453-4057qib7 8535 11 analyzed analyze VBN cord-005453-4057qib7 8535 12 . . . cord-005453-4057qib7 8536 1 Results result NNS cord-005453-4057qib7 8536 2 : : : cord-005453-4057qib7 8537 1 A a DT cord-005453-4057qib7 8537 2 total total NN cord-005453-4057qib7 8537 3 of of IN cord-005453-4057qib7 8537 4 44 44 CD cord-005453-4057qib7 8537 5 patients patient NNS cord-005453-4057qib7 8537 6 were be VBD cord-005453-4057qib7 8537 7 enrolled enrol VBN cord-005453-4057qib7 8537 8 . . . cord-005453-4057qib7 8538 1 There there EX cord-005453-4057qib7 8538 2 were be VBD cord-005453-4057qib7 8538 3 31 31 CD cord-005453-4057qib7 8538 4 patients patient NNS cord-005453-4057qib7 8538 5 with with IN cord-005453-4057qib7 8538 6 FHL FHL NNP cord-005453-4057qib7 8538 7 ( ( -LRB- cord-005453-4057qib7 8538 8 4 4 CD cord-005453-4057qib7 8538 9 FHL2 FHL2 NNP cord-005453-4057qib7 8538 10 , , , cord-005453-4057qib7 8538 11 26 26 CD cord-005453-4057qib7 8538 12 FHL3 FHL3 NNP cord-005453-4057qib7 8538 13 , , , cord-005453-4057qib7 8538 14 and and CC cord-005453-4057qib7 8538 15 1 1 CD cord-005453-4057qib7 8538 16 FHL4 FHL4 NNP cord-005453-4057qib7 8538 17 ) ) -RRB- cord-005453-4057qib7 8538 18 , , , cord-005453-4057qib7 8538 19 7 7 CD cord-005453-4057qib7 8538 20 infection infection NN cord-005453-4057qib7 8538 21 associated associate VBD cord-005453-4057qib7 8538 22 HLH HLH NNP cord-005453-4057qib7 8538 23 , , , cord-005453-4057qib7 8538 24 and and CC cord-005453-4057qib7 8538 25 6 6 CD cord-005453-4057qib7 8538 26 secondary secondary JJ cord-005453-4057qib7 8538 27 HLH hlh NN cord-005453-4057qib7 8538 28 of of IN cord-005453-4057qib7 8538 29 unknown unknown JJ cord-005453-4057qib7 8538 30 cause cause NN cord-005453-4057qib7 8538 31 . . . cord-005453-4057qib7 8539 1 All all PDT cord-005453-4057qib7 8539 2 the the DT cord-005453-4057qib7 8539 3 patients patient NNS cord-005453-4057qib7 8539 4 were be VBD cord-005453-4057qib7 8539 5 treated treat VBN cord-005453-4057qib7 8539 6 with with IN cord-005453-4057qib7 8539 7 HLH-2004 HLH-2004 NNP cord-005453-4057qib7 8539 8 protocol protocol NN cord-005453-4057qib7 8539 9 , , , cord-005453-4057qib7 8539 10 and and CC cord-005453-4057qib7 8539 11 30 30 CD cord-005453-4057qib7 8539 12 patients patient NNS cord-005453-4057qib7 8539 13 achieved achieve VBD cord-005453-4057qib7 8539 14 complete complete JJ cord-005453-4057qib7 8539 15 response response NN cord-005453-4057qib7 8539 16 ( ( -LRB- cord-005453-4057qib7 8539 17 CR cr NN cord-005453-4057qib7 8539 18 ) ) -RRB- cord-005453-4057qib7 8539 19 after after IN cord-005453-4057qib7 8539 20 treatment treatment NN cord-005453-4057qib7 8539 21 for for IN cord-005453-4057qib7 8539 22 8 8 CD cord-005453-4057qib7 8539 23 weeks week NNS cord-005453-4057qib7 8539 24 , , , cord-005453-4057qib7 8539 25 while while IN cord-005453-4057qib7 8539 26 14 14 CD cord-005453-4057qib7 8539 27 did do VBD cord-005453-4057qib7 8539 28 not not RB cord-005453-4057qib7 8539 29 . . . cord-005453-4057qib7 8540 1 The the DT cord-005453-4057qib7 8540 2 main main JJ cord-005453-4057qib7 8540 3 reasons reason NNS cord-005453-4057qib7 8540 4 for for IN cord-005453-4057qib7 8540 5 receiving receive VBG cord-005453-4057qib7 8540 6 transplantation transplantation NN cord-005453-4057qib7 8540 7 were be VBD cord-005453-4057qib7 8540 8 FHL FHL NNP cord-005453-4057qib7 8540 9 in in IN cord-005453-4057qib7 8540 10 26 26 CD cord-005453-4057qib7 8540 11 , , , cord-005453-4057qib7 8540 12 reactivation reactivation NN cord-005453-4057qib7 8540 13 in in IN cord-005453-4057qib7 8540 14 17 17 CD cord-005453-4057qib7 8540 15 , , , cord-005453-4057qib7 8540 16 and and CC cord-005453-4057qib7 8540 17 refractory refractory JJ cord-005453-4057qib7 8540 18 disease disease NN cord-005453-4057qib7 8540 19 in in IN cord-005453-4057qib7 8540 20 1 1 CD cord-005453-4057qib7 8540 21 . . . cord-005453-4057qib7 8541 1 The the DT cord-005453-4057qib7 8541 2 conditioning conditioning NN cord-005453-4057qib7 8541 3 regimens regimen NNS cord-005453-4057qib7 8541 4 were be VBD cord-005453-4057qib7 8541 5 busulfan busulfan NN cord-005453-4057qib7 8541 6 - - HYPH cord-005453-4057qib7 8541 7 based base VBN cord-005453-4057qib7 8541 8 in in IN cord-005453-4057qib7 8541 9 16 16 CD cord-005453-4057qib7 8541 10 patients patient NNS cord-005453-4057qib7 8541 11 , , , cord-005453-4057qib7 8541 12 fludarabine fludarabine NN cord-005453-4057qib7 8541 13 - - HYPH cord-005453-4057qib7 8541 14 based base VBN cord-005453-4057qib7 8541 15 in in IN cord-005453-4057qib7 8541 16 4 4 CD cord-005453-4057qib7 8541 17 , , , cord-005453-4057qib7 8541 18 treosulfan treosulfan NNP cord-005453-4057qib7 8541 19 - - HYPH cord-005453-4057qib7 8541 20 based base VBN cord-005453-4057qib7 8541 21 in in IN cord-005453-4057qib7 8541 22 7 7 CD cord-005453-4057qib7 8541 23 , , , cord-005453-4057qib7 8541 24 and and CC cord-005453-4057qib7 8541 25 busulfan busulfan NN cord-005453-4057qib7 8541 26 / / SYM cord-005453-4057qib7 8541 27 fludarabine fludarabine NN cord-005453-4057qib7 8541 28 - - HYPH cord-005453-4057qib7 8541 29 based base VBN cord-005453-4057qib7 8541 30 in in IN cord-005453-4057qib7 8541 31 17 17 CD cord-005453-4057qib7 8541 32 . . . cord-005453-4057qib7 8542 1 Stem stem JJ cord-005453-4057qib7 8542 2 cell cell NN cord-005453-4057qib7 8542 3 sources source NNS cord-005453-4057qib7 8542 4 used use VBN cord-005453-4057qib7 8542 5 for for IN cord-005453-4057qib7 8542 6 HSCT HSCT NNP cord-005453-4057qib7 8542 7 were be VBD cord-005453-4057qib7 8542 8 from from IN cord-005453-4057qib7 8542 9 peripheral peripheral JJ cord-005453-4057qib7 8542 10 blood blood NN cord-005453-4057qib7 8542 11 in in IN cord-005453-4057qib7 8542 12 36 36 CD cord-005453-4057qib7 8542 13 patient patient NN cord-005453-4057qib7 8542 14 , , , cord-005453-4057qib7 8542 15 cord cord NN cord-005453-4057qib7 8542 16 blood blood NN cord-005453-4057qib7 8542 17 in in IN cord-005453-4057qib7 8542 18 7 7 CD cord-005453-4057qib7 8542 19 , , , cord-005453-4057qib7 8542 20 and and CC cord-005453-4057qib7 8542 21 bone bone NN cord-005453-4057qib7 8542 22 marrow marrow NN cord-005453-4057qib7 8542 23 in in IN cord-005453-4057qib7 8542 24 1 1 CD cord-005453-4057qib7 8542 25 . . . cord-005453-4057qib7 8543 1 The the DT cord-005453-4057qib7 8543 2 donor donor NN cord-005453-4057qib7 8543 3 types type NNS cord-005453-4057qib7 8543 4 of of IN cord-005453-4057qib7 8543 5 HSCT HSCT NNP cord-005453-4057qib7 8543 6 were be VBD cord-005453-4057qib7 8543 7 unrelated unrelated JJ cord-005453-4057qib7 8543 8 donor donor NN cord-005453-4057qib7 8543 9 in in IN cord-005453-4057qib7 8543 10 33 33 CD cord-005453-4057qib7 8543 11 patients patient NNS cord-005453-4057qib7 8543 12 and and CC cord-005453-4057qib7 8543 13 related relate VBN cord-005453-4057qib7 8543 14 in in IN cord-005453-4057qib7 8543 15 11 11 CD cord-005453-4057qib7 8543 16 ( ( -LRB- cord-005453-4057qib7 8543 17 7 7 CD cord-005453-4057qib7 8543 18 matched match VBN cord-005453-4057qib7 8543 19 sibling sibling NN cord-005453-4057qib7 8543 20 donor donor NN cord-005453-4057qib7 8543 21 , , , cord-005453-4057qib7 8543 22 4 4 CD cord-005453-4057qib7 8543 23 haploidentical haploidentical JJ cord-005453-4057qib7 8543 24 donor donor NN cord-005453-4057qib7 8543 25 , , , cord-005453-4057qib7 8543 26 1 1 CD cord-005453-4057qib7 8543 27 partially partially RB cord-005453-4057qib7 8543 28 matched match VBN cord-005453-4057qib7 8543 29 donor donor NN cord-005453-4057qib7 8543 30 ) ) -RRB- cord-005453-4057qib7 8543 31 . . . cord-005453-4057qib7 8544 1 The the DT cord-005453-4057qib7 8544 2 causes cause NNS cord-005453-4057qib7 8544 3 of of IN cord-005453-4057qib7 8544 4 death death NN cord-005453-4057qib7 8544 5 of of IN cord-005453-4057qib7 8544 6 7 7 CD cord-005453-4057qib7 8544 7 patients patient NNS cord-005453-4057qib7 8544 8 were be VBD cord-005453-4057qib7 8544 9 disease disease NN cord-005453-4057qib7 8544 10 reactivation/ reactivation/ ADD cord-005453-4057qib7 8544 11 progression progression NN cord-005453-4057qib7 8544 12 in in IN cord-005453-4057qib7 8544 13 3 3 CD cord-005453-4057qib7 8544 14 , , , cord-005453-4057qib7 8544 15 acute acute JJ cord-005453-4057qib7 8544 16 GVHD GVHD NNP cord-005453-4057qib7 8544 17 with with IN cord-005453-4057qib7 8544 18 / / SYM cord-005453-4057qib7 8544 19 without without IN cord-005453-4057qib7 8544 20 VOD VOD NNP cord-005453-4057qib7 8544 21 in in IN cord-005453-4057qib7 8544 22 3 3 CD cord-005453-4057qib7 8544 23 , , , cord-005453-4057qib7 8544 24 and and CC cord-005453-4057qib7 8544 25 graft graft NN cord-005453-4057qib7 8544 26 failure failure NN cord-005453-4057qib7 8544 27 in in IN cord-005453-4057qib7 8544 28 1 1 CD cord-005453-4057qib7 8544 29 . . . cord-005453-4057qib7 8545 1 Five five CD cord-005453-4057qib7 8545 2 year year NN cord-005453-4057qib7 8545 3 overall overall JJ cord-005453-4057qib7 8545 4 survival survival NN cord-005453-4057qib7 8545 5 rates rate NNS cord-005453-4057qib7 8545 6 were be VBD cord-005453-4057qib7 8545 7 82.4 82.4 CD cord-005453-4057qib7 8545 8 % % NN cord-005453-4057qib7 8545 9 , , , cord-005453-4057qib7 8545 10 respectively respectively RB cord-005453-4057qib7 8545 11 . . . cord-005453-4057qib7 8546 1 The the DT cord-005453-4057qib7 8546 2 disease disease NN cord-005453-4057qib7 8546 3 status status NN cord-005453-4057qib7 8546 4 at at IN cord-005453-4057qib7 8546 5 the the DT cord-005453-4057qib7 8546 6 time time NN cord-005453-4057qib7 8546 7 of of IN cord-005453-4057qib7 8546 8 HSCT HSCT NNP cord-005453-4057qib7 8546 9 was be VBD cord-005453-4057qib7 8546 10 CR CR NNP cord-005453-4057qib7 8546 11 in in IN cord-005453-4057qib7 8546 12 37 37 CD cord-005453-4057qib7 8546 13 patients patient NNS cord-005453-4057qib7 8546 14 , , , cord-005453-4057qib7 8546 15 and and CC cord-005453-4057qib7 8546 16 non non JJ cord-005453-4057qib7 8546 17 - - JJ cord-005453-4057qib7 8546 18 CR CR NNP cord-005453-4057qib7 8546 19 in in IN cord-005453-4057qib7 8546 20 7 7 CD cord-005453-4057qib7 8546 21 . . . cord-005453-4057qib7 8547 1 The the DT cord-005453-4057qib7 8547 2 5-year 5-year CD cord-005453-4057qib7 8547 3 survival survival NN cord-005453-4057qib7 8547 4 rate rate NN cord-005453-4057qib7 8547 5 of of IN cord-005453-4057qib7 8547 6 patients patient NNS cord-005453-4057qib7 8547 7 who who WP cord-005453-4057qib7 8547 8 received receive VBD cord-005453-4057qib7 8547 9 HSCT HSCT NNP cord-005453-4057qib7 8547 10 in in IN cord-005453-4057qib7 8547 11 CR CR NNP cord-005453-4057qib7 8547 12 was be VBD cord-005453-4057qib7 8547 13 87 87 CD cord-005453-4057qib7 8547 14 % % NN cord-005453-4057qib7 8547 15 and and CC cord-005453-4057qib7 8547 16 63 63 CD cord-005453-4057qib7 8547 17 % % NN cord-005453-4057qib7 8547 18 for for IN cord-005453-4057qib7 8547 19 patients patient NNS cord-005453-4057qib7 8547 20 transplanted transplant VBN cord-005453-4057qib7 8547 21 while while IN cord-005453-4057qib7 8547 22 in in IN cord-005453-4057qib7 8547 23 non non JJ cord-005453-4057qib7 8547 24 - - JJ cord-005453-4057qib7 8547 25 CR cr JJ cord-005453-4057qib7 8547 26 status status NN cord-005453-4057qib7 8547 27 ( ( -LRB- cord-005453-4057qib7 8547 28 p=0.046 p=0.046 NNP cord-005453-4057qib7 8547 29 ) ) -RRB- cord-005453-4057qib7 8547 30 . . . cord-005453-4057qib7 8548 1 Patients patient NNS cord-005453-4057qib7 8548 2 who who WP cord-005453-4057qib7 8548 3 received receive VBD cord-005453-4057qib7 8548 4 HSCT HSCT NNP cord-005453-4057qib7 8548 5 using use VBG cord-005453-4057qib7 8548 6 peripheral peripheral JJ cord-005453-4057qib7 8548 7 blood blood NN cord-005453-4057qib7 8548 8 stem stem NN cord-005453-4057qib7 8548 9 cells cell NNS cord-005453-4057qib7 8548 10 had have VBD cord-005453-4057qib7 8548 11 a a DT cord-005453-4057qib7 8548 12 better well JJR cord-005453-4057qib7 8548 13 5-year 5-year CD cord-005453-4057qib7 8548 14 survival survival NN cord-005453-4057qib7 8548 15 rate rate NN cord-005453-4057qib7 8548 16 of of IN cord-005453-4057qib7 8548 17 86 86 CD cord-005453-4057qib7 8548 18 % % NN cord-005453-4057qib7 8548 19 compared compare VBN cord-005453-4057qib7 8548 20 to to IN cord-005453-4057qib7 8548 21 75 75 CD cord-005453-4057qib7 8548 22 % % NN cord-005453-4057qib7 8548 23 of of IN cord-005453-4057qib7 8548 24 patients patient NNS cord-005453-4057qib7 8548 25 who who WP cord-005453-4057qib7 8548 26 received receive VBD cord-005453-4057qib7 8548 27 cord cord NN cord-005453-4057qib7 8548 28 blood blood NN cord-005453-4057qib7 8548 29 stem stem NN cord-005453-4057qib7 8548 30 cells cell NNS cord-005453-4057qib7 8548 31 , , , cord-005453-4057qib7 8548 32 significantly significantly RB cord-005453-4057qib7 8548 33 . . . cord-005453-4057qib7 8549 1 The the DT cord-005453-4057qib7 8549 2 presence presence NN cord-005453-4057qib7 8549 3 of of IN cord-005453-4057qib7 8549 4 neurologic neurologic JJ cord-005453-4057qib7 8549 5 symptoms symptom NNS cord-005453-4057qib7 8549 6 , , , cord-005453-4057qib7 8549 7 disease disease NN cord-005453-4057qib7 8549 8 status status NN cord-005453-4057qib7 8549 9 after after IN cord-005453-4057qib7 8549 10 intial intial JJ cord-005453-4057qib7 8549 11 8 8 CD cord-005453-4057qib7 8549 12 week week NN cord-005453-4057qib7 8549 13 therapy therapy NN cord-005453-4057qib7 8549 14 , , , cord-005453-4057qib7 8549 15 conditioning conditioning NN cord-005453-4057qib7 8549 16 regimen regimen NN cord-005453-4057qib7 8549 17 , , , cord-005453-4057qib7 8549 18 and and CC cord-005453-4057qib7 8549 19 CD CD NNP cord-005453-4057qib7 8549 20 34 34 CD cord-005453-4057qib7 8549 21 positive positive JJ cord-005453-4057qib7 8549 22 cell cell NN cord-005453-4057qib7 8549 23 count count NN cord-005453-4057qib7 8549 24 did do VBD cord-005453-4057qib7 8549 25 not not RB cord-005453-4057qib7 8549 26 have have VB cord-005453-4057qib7 8549 27 statistically statistically RB cord-005453-4057qib7 8549 28 significant significant JJ cord-005453-4057qib7 8549 29 impact impact NN cord-005453-4057qib7 8549 30 on on IN cord-005453-4057qib7 8549 31 survival survival NN cord-005453-4057qib7 8549 32 . . . cord-005453-4057qib7 8550 1 Conclusions conclusion NNS cord-005453-4057qib7 8550 2 : : : cord-005453-4057qib7 8550 3 HSCT HSCT NNP cord-005453-4057qib7 8550 4 improved improve VBD cord-005453-4057qib7 8550 5 the the DT cord-005453-4057qib7 8550 6 survival survival NN cord-005453-4057qib7 8550 7 of of IN cord-005453-4057qib7 8550 8 patients patient NNS cord-005453-4057qib7 8550 9 who who WP cord-005453-4057qib7 8550 10 had have VBD cord-005453-4057qib7 8550 11 familial familial JJ cord-005453-4057qib7 8550 12 , , , cord-005453-4057qib7 8550 13 or or CC cord-005453-4057qib7 8550 14 relapsed relapse VBN cord-005453-4057qib7 8550 15 , , , cord-005453-4057qib7 8550 16 or or CC cord-005453-4057qib7 8550 17 refractory refractory JJ cord-005453-4057qib7 8550 18 HLH HLH NNP cord-005453-4057qib7 8550 19 in in IN cord-005453-4057qib7 8550 20 the the DT cord-005453-4057qib7 8550 21 Korean korean JJ cord-005453-4057qib7 8550 22 nation nation NN cord-005453-4057qib7 8550 23 - - HYPH cord-005453-4057qib7 8550 24 wide wide JJ cord-005453-4057qib7 8550 25 HLH HLH NNP cord-005453-4057qib7 8550 26 registry registry NN cord-005453-4057qib7 8550 27 . . . cord-005453-4057qib7 8551 1 These these DT cord-005453-4057qib7 8551 2 results result NNS cord-005453-4057qib7 8551 3 are be VBP cord-005453-4057qib7 8551 4 similar similar JJ cord-005453-4057qib7 8551 5 to to IN cord-005453-4057qib7 8551 6 other other JJ cord-005453-4057qib7 8551 7 reports report NNS cord-005453-4057qib7 8551 8 in in IN cord-005453-4057qib7 8551 9 the the DT cord-005453-4057qib7 8551 10 literature literature NN cord-005453-4057qib7 8551 11 . . . cord-005453-4057qib7 8552 1 The the DT cord-005453-4057qib7 8552 2 disease disease NN cord-005453-4057qib7 8552 3 status status NN cord-005453-4057qib7 8552 4 at at IN cord-005453-4057qib7 8552 5 the the DT cord-005453-4057qib7 8552 6 time time NN cord-005453-4057qib7 8552 7 of of IN cord-005453-4057qib7 8552 8 HSCT HSCT NNP cord-005453-4057qib7 8552 9 and and CC cord-005453-4057qib7 8552 10 the the DT cord-005453-4057qib7 8552 11 stem stem NN cord-005453-4057qib7 8552 12 cell cell NN cord-005453-4057qib7 8552 13 source source NN cord-005453-4057qib7 8552 14 of of IN cord-005453-4057qib7 8552 15 the the DT cord-005453-4057qib7 8552 16 transplant transplant NN cord-005453-4057qib7 8552 17 were be VBD cord-005453-4057qib7 8552 18 the the DT cord-005453-4057qib7 8552 19 important important JJ cord-005453-4057qib7 8552 20 prognostic prognostic JJ cord-005453-4057qib7 8552 21 factors factor NNS cord-005453-4057qib7 8552 22 that that WDT cord-005453-4057qib7 8552 23 affected affect VBD cord-005453-4057qib7 8552 24 the the DT cord-005453-4057qib7 8552 25 survivals survival NNS cord-005453-4057qib7 8552 26 of of IN cord-005453-4057qib7 8552 27 the the DT cord-005453-4057qib7 8552 28 HLH HLH NNP cord-005453-4057qib7 8552 29 patients patient NNS cord-005453-4057qib7 8552 30 who who WP cord-005453-4057qib7 8552 31 underwent undergo VBD cord-005453-4057qib7 8552 32 HSCT HSCT NNP cord-005453-4057qib7 8552 33 . . . cord-005453-4057qib7 8553 1 Clinical clinical JJ cord-005453-4057qib7 8553 2 Trial Trial NNP cord-005453-4057qib7 8553 3 Registry Registry NNP cord-005453-4057qib7 8553 4 : : : cord-005453-4057qib7 8553 5 No no DT cord-005453-4057qib7 8553 6 registry registry NN cord-005453-4057qib7 8553 7 number number NN cord-005453-4057qib7 8553 8 . . . cord-005453-4057qib7 8554 1 Disclosure disclosure NN cord-005453-4057qib7 8554 2 : : : cord-005453-4057qib7 8555 1 To to IN cord-005453-4057qib7 8555 2 the the DT cord-005453-4057qib7 8555 3 best good JJS cord-005453-4057qib7 8555 4 of of IN cord-005453-4057qib7 8555 5 our -PRON- PRP$ cord-005453-4057qib7 8555 6 knowledge knowledge NN cord-005453-4057qib7 8555 7 , , , cord-005453-4057qib7 8555 8 the the DT cord-005453-4057qib7 8555 9 named name VBN cord-005453-4057qib7 8555 10 authors author NNS cord-005453-4057qib7 8555 11 have have VBP cord-005453-4057qib7 8555 12 no no DT cord-005453-4057qib7 8555 13 conflict conflict NN cord-005453-4057qib7 8555 14 of of IN cord-005453-4057qib7 8555 15 interest interest NN cord-005453-4057qib7 8555 16 , , , cord-005453-4057qib7 8555 17 financial financial JJ cord-005453-4057qib7 8555 18 or or CC cord-005453-4057qib7 8555 19 otherwise otherwise RB cord-005453-4057qib7 8555 20 P382 p382 CD cord-005453-4057qib7 8555 21 Hematopoietic hematopoietic JJ cord-005453-4057qib7 8555 22 cell cell NN cord-005453-4057qib7 8555 23 transplantation transplantation NN cord-005453-4057qib7 8555 24 with with IN cord-005453-4057qib7 8555 25 reduced reduce VBN cord-005453-4057qib7 8555 26 intensity intensity NN cord-005453-4057qib7 8555 27 conditioning conditioning NN cord-005453-4057qib7 8555 28 regimen regimen NN cord-005453-4057qib7 8555 29 using use VBG cord-005453-4057qib7 8555 30 fludarabine/ fludarabine/ CD cord-005453-4057qib7 8555 31 busulfan busulfan NN cord-005453-4057qib7 8555 32 and and CC cord-005453-4057qib7 8555 33 fludarabine fludarabine NN cord-005453-4057qib7 8555 34 / / SYM cord-005453-4057qib7 8555 35 melphalan melphalan NN cord-005453-4057qib7 8555 36 for for IN cord-005453-4057qib7 8555 37 primary primary JJ cord-005453-4057qib7 8555 38 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8555 39 diseases disease NNS cord-005453-4057qib7 8555 40 Background Background NNP cord-005453-4057qib7 8555 41 : : : cord-005453-4057qib7 8555 42 Primary primary JJ cord-005453-4057qib7 8555 43 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8555 44 disease disease NN cord-005453-4057qib7 8555 45 ( ( -LRB- cord-005453-4057qib7 8555 46 PID PID NNP cord-005453-4057qib7 8555 47 ) ) -RRB- cord-005453-4057qib7 8555 48 is be VBZ cord-005453-4057qib7 8555 49 congenital congenital JJ cord-005453-4057qib7 8555 50 disorders disorder NNS cord-005453-4057qib7 8555 51 of of IN cord-005453-4057qib7 8555 52 innate innate JJ cord-005453-4057qib7 8555 53 or or CC cord-005453-4057qib7 8555 54 acquired acquire VBN cord-005453-4057qib7 8555 55 immune immune JJ cord-005453-4057qib7 8555 56 system system NN cord-005453-4057qib7 8555 57 . . . cord-005453-4057qib7 8556 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 8556 2 cell cell NN cord-005453-4057qib7 8556 3 transplantation transplantation NN cord-005453-4057qib7 8556 4 ( ( -LRB- cord-005453-4057qib7 8556 5 HCT HCT NNP cord-005453-4057qib7 8556 6 ) ) -RRB- cord-005453-4057qib7 8556 7 was be VBD cord-005453-4057qib7 8556 8 a a DT cord-005453-4057qib7 8556 9 treatment treatment NN cord-005453-4057qib7 8556 10 option option NN cord-005453-4057qib7 8556 11 for for IN cord-005453-4057qib7 8556 12 PIDs pid NNS cord-005453-4057qib7 8556 13 with with IN cord-005453-4057qib7 8556 14 life life NN cord-005453-4057qib7 8556 15 - - HYPH cord-005453-4057qib7 8556 16 threatening threaten VBG cord-005453-4057qib7 8556 17 infections infection NNS cord-005453-4057qib7 8556 18 or or CC cord-005453-4057qib7 8556 19 immune immune JJ cord-005453-4057qib7 8556 20 dysregulations dysregulation NNS cord-005453-4057qib7 8556 21 . . . cord-005453-4057qib7 8557 1 Reduced reduced JJ cord-005453-4057qib7 8557 2 intensity intensity NN cord-005453-4057qib7 8557 3 conditioning conditioning NN cord-005453-4057qib7 8557 4 ( ( -LRB- cord-005453-4057qib7 8557 5 RIC RIC NNP cord-005453-4057qib7 8557 6 ) ) -RRB- cord-005453-4057qib7 8557 7 was be VBD cord-005453-4057qib7 8557 8 increasingly increasingly RB cord-005453-4057qib7 8557 9 used use VBN cord-005453-4057qib7 8557 10 to to TO cord-005453-4057qib7 8557 11 prevent prevent VB cord-005453-4057qib7 8557 12 complications complication NNS cord-005453-4057qib7 8557 13 in in IN cord-005453-4057qib7 8557 14 HCT hct NN cord-005453-4057qib7 8557 15 , , , cord-005453-4057qib7 8557 16 but but CC cord-005453-4057qib7 8557 17 optimized optimize VBN cord-005453-4057qib7 8557 18 regimens regimen NNS cord-005453-4057qib7 8557 19 have have VBP cord-005453-4057qib7 8557 20 not not RB cord-005453-4057qib7 8557 21 been be VBN cord-005453-4057qib7 8557 22 established establish VBN cord-005453-4057qib7 8557 23 . . . cord-005453-4057qib7 8558 1 We -PRON- PRP cord-005453-4057qib7 8558 2 performed perform VBD cord-005453-4057qib7 8558 3 HCT hct NN cord-005453-4057qib7 8558 4 for for IN cord-005453-4057qib7 8558 5 PIDs pid NNS cord-005453-4057qib7 8558 6 with with IN cord-005453-4057qib7 8558 7 RIC RIC NNP cord-005453-4057qib7 8558 8 using use VBG cord-005453-4057qib7 8558 9 fludarabine fludarabine NN cord-005453-4057qib7 8558 10 and and CC cord-005453-4057qib7 8558 11 busulfan busulfan NN cord-005453-4057qib7 8558 12 ( ( -LRB- cord-005453-4057qib7 8558 13 FluBU FluBU NNP cord-005453-4057qib7 8558 14 ) ) -RRB- cord-005453-4057qib7 8558 15 or or CC cord-005453-4057qib7 8558 16 melphalan melphalan NNP cord-005453-4057qib7 8558 17 ( ( -LRB- cord-005453-4057qib7 8558 18 FluMel FluMel NNP cord-005453-4057qib7 8558 19 ) ) -RRB- cord-005453-4057qib7 8558 20 according accord VBG cord-005453-4057qib7 8558 21 to to IN cord-005453-4057qib7 8558 22 the the DT cord-005453-4057qib7 8558 23 guidelines guideline NNS cord-005453-4057qib7 8558 24 of of IN cord-005453-4057qib7 8558 25 European European NNP cord-005453-4057qib7 8558 26 Society Society NNP cord-005453-4057qib7 8558 27 for for IN cord-005453-4057qib7 8558 28 Immunodeficiencies Immunodeficiencies NNP cord-005453-4057qib7 8558 29 ( ( -LRB- cord-005453-4057qib7 8558 30 ESID ESID NNP cord-005453-4057qib7 8558 31 ) ) -RRB- cord-005453-4057qib7 8559 1 / / SYM cord-005453-4057qib7 8559 2 European European NNP cord-005453-4057qib7 8559 3 Society Society NNP cord-005453-4057qib7 8559 4 for for IN cord-005453-4057qib7 8559 5 Blood blood NN cord-005453-4057qib7 8559 6 and and CC cord-005453-4057qib7 8559 7 Marrow marrow NN cord-005453-4057qib7 8559 8 Transplantation transplantation NN cord-005453-4057qib7 8559 9 ( ( -LRB- cord-005453-4057qib7 8559 10 EBMT EBMT NNP cord-005453-4057qib7 8559 11 ) ) -RRB- cord-005453-4057qib7 8559 12 , , , cord-005453-4057qib7 8559 13 and and CC cord-005453-4057qib7 8559 14 assessed assess VBD cord-005453-4057qib7 8559 15 the the DT cord-005453-4057qib7 8559 16 efficacy efficacy NN cord-005453-4057qib7 8559 17 and and CC cord-005453-4057qib7 8559 18 safety safety NN cord-005453-4057qib7 8559 19 of of IN cord-005453-4057qib7 8559 20 these these DT cord-005453-4057qib7 8559 21 RIC RIC NNP cord-005453-4057qib7 8559 22 . . . cord-005453-4057qib7 8560 1 Methods method NNS cord-005453-4057qib7 8560 2 : : : cord-005453-4057qib7 8561 1 From from IN cord-005453-4057qib7 8561 2 April April NNP cord-005453-4057qib7 8561 3 2004 2004 CD cord-005453-4057qib7 8561 4 to to IN cord-005453-4057qib7 8561 5 December December NNP cord-005453-4057qib7 8561 6 2017 2017 CD cord-005453-4057qib7 8561 7 , , , cord-005453-4057qib7 8561 8 42 42 CD cord-005453-4057qib7 8561 9 PID PID NNP cord-005453-4057qib7 8561 10 patients patient NNS cord-005453-4057qib7 8561 11 underwent undergo VBD cord-005453-4057qib7 8561 12 RIC RIC NNP cord-005453-4057qib7 8561 13 - - HYPH cord-005453-4057qib7 8561 14 HCT HCT NNP cord-005453-4057qib7 8561 15 using use VBG cord-005453-4057qib7 8561 16 FluBU FluBU NNP cord-005453-4057qib7 8561 17 or or CC cord-005453-4057qib7 8561 18 FluMel FluMel NNP cord-005453-4057qib7 8561 19 in in IN cord-005453-4057qib7 8561 20 TMDU TMDU NNP cord-005453-4057qib7 8561 21 were be VBD cord-005453-4057qib7 8561 22 analyzed analyze VBN cord-005453-4057qib7 8561 23 retrospectively retrospectively RB cord-005453-4057qib7 8561 24 . . . cord-005453-4057qib7 8562 1 The the DT cord-005453-4057qib7 8562 2 AUC AUC NNP cord-005453-4057qib7 8562 3 of of IN cord-005453-4057qib7 8562 4 BU BU NNP cord-005453-4057qib7 8562 5 was be VBD cord-005453-4057qib7 8562 6 set set VBN cord-005453-4057qib7 8562 7 to to IN cord-005453-4057qib7 8562 8 30 30 CD cord-005453-4057qib7 8562 9 mg*hour mg*hour NNP cord-005453-4057qib7 8562 10 / / SYM cord-005453-4057qib7 8562 11 L l NN cord-005453-4057qib7 8562 12 for for IN cord-005453-4057qib7 8562 13 severe severe JJ cord-005453-4057qib7 8562 14 combined combine VBN cord-005453-4057qib7 8562 15 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8562 16 disease disease NN cord-005453-4057qib7 8562 17 ( ( -LRB- cord-005453-4057qib7 8562 18 SCID SCID NNP cord-005453-4057qib7 8562 19 ) ) -RRB- cord-005453-4057qib7 8562 20 and and CC cord-005453-4057qib7 8562 21 60 60 CD cord-005453-4057qib7 8562 22 mg*hour mg*hour NNP cord-005453-4057qib7 8562 23 / / SYM cord-005453-4057qib7 8562 24 L l NN cord-005453-4057qib7 8562 25 for for IN cord-005453-4057qib7 8562 26 non non JJ cord-005453-4057qib7 8562 27 - - JJ cord-005453-4057qib7 8562 28 SCID scid JJ cord-005453-4057qib7 8562 29 . . . cord-005453-4057qib7 8563 1 Overall overall JJ cord-005453-4057qib7 8563 2 survival survival NN cord-005453-4057qib7 8563 3 ( ( -LRB- cord-005453-4057qib7 8563 4 OS OS NNP cord-005453-4057qib7 8563 5 ) ) -RRB- cord-005453-4057qib7 8563 6 was be VBD cord-005453-4057qib7 8563 7 analyzed analyze VBN cord-005453-4057qib7 8563 8 . . . cord-005453-4057qib7 8564 1 Results result NNS cord-005453-4057qib7 8564 2 : : : cord-005453-4057qib7 8565 1 The the DT cord-005453-4057qib7 8565 2 median median JJ cord-005453-4057qib7 8565 3 age age NN cord-005453-4057qib7 8565 4 at at IN cord-005453-4057qib7 8565 5 HCT HCT NNP cord-005453-4057qib7 8565 6 was be VBD cord-005453-4057qib7 8565 7 2.0 2.0 CD cord-005453-4057qib7 8565 8 ( ( -LRB- cord-005453-4057qib7 8565 9 0.3 0.3 CD cord-005453-4057qib7 8565 10 - - SYM cord-005453-4057qib7 8565 11 21 21 CD cord-005453-4057qib7 8565 12 ) ) -RRB- cord-005453-4057qib7 8565 13 years year NNS cord-005453-4057qib7 8565 14 old old JJ cord-005453-4057qib7 8565 15 ( ( -LRB- cord-005453-4057qib7 8565 16 35 35 CD cord-005453-4057qib7 8565 17 male male NN cord-005453-4057qib7 8565 18 and and CC cord-005453-4057qib7 8565 19 7 7 CD cord-005453-4057qib7 8565 20 female female JJ cord-005453-4057qib7 8565 21 patients patient NNS cord-005453-4057qib7 8565 22 ) ) -RRB- cord-005453-4057qib7 8565 23 . . . cord-005453-4057qib7 8566 1 FluBU FluBU NNP cord-005453-4057qib7 8566 2 was be VBD cord-005453-4057qib7 8566 3 used use VBN cord-005453-4057qib7 8566 4 for for IN cord-005453-4057qib7 8566 5 23 23 CD cord-005453-4057qib7 8566 6 patients patient NNS cord-005453-4057qib7 8566 7 ( ( -LRB- cord-005453-4057qib7 8566 8 7 7 CD cord-005453-4057qib7 8566 9 SCID SCID NNP cord-005453-4057qib7 8566 10 , , , cord-005453-4057qib7 8566 11 9 9 CD cord-005453-4057qib7 8566 12 combined combine VBN cord-005453-4057qib7 8566 13 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8566 14 disease disease NN cord-005453-4057qib7 8566 15 ( ( -LRB- cord-005453-4057qib7 8566 16 CID CID NNP cord-005453-4057qib7 8566 17 ) ) -RRB- cord-005453-4057qib7 8566 18 , , , cord-005453-4057qib7 8566 19 3 3 CD cord-005453-4057qib7 8566 20 ectodermal ectodermal JJ cord-005453-4057qib7 8566 21 dysplasia dysplasia NN cord-005453-4057qib7 8566 22 ( ( -LRB- cord-005453-4057qib7 8566 23 EDA EDA NNP cord-005453-4057qib7 8566 24 ) ) -RRB- cord-005453-4057qib7 8566 25 , , , cord-005453-4057qib7 8566 26 and and CC cord-005453-4057qib7 8566 27 4 4 CD cord-005453-4057qib7 8566 28 severe severe JJ cord-005453-4057qib7 8566 29 congenital congenital JJ cord-005453-4057qib7 8566 30 neutropenia neutropenia NN cord-005453-4057qib7 8566 31 ( ( -LRB- cord-005453-4057qib7 8566 32 SCN SCN NNP cord-005453-4057qib7 8566 33 ) ) -RRB- cord-005453-4057qib7 8566 34 ) ) -RRB- cord-005453-4057qib7 8567 1 and and CC cord-005453-4057qib7 8567 2 FluMel FluMel NNP cord-005453-4057qib7 8567 3 was be VBD cord-005453-4057qib7 8567 4 used use VBN cord-005453-4057qib7 8567 5 for for IN cord-005453-4057qib7 8567 6 19 19 CD cord-005453-4057qib7 8567 7 patients patient NNS cord-005453-4057qib7 8567 8 ( ( -LRB- cord-005453-4057qib7 8567 9 8 8 CD cord-005453-4057qib7 8567 10 SCID SCID NNP cord-005453-4057qib7 8567 11 , , , cord-005453-4057qib7 8567 12 6 6 CD cord-005453-4057qib7 8567 13 CID CID NNP cord-005453-4057qib7 8567 14 , , , cord-005453-4057qib7 8567 15 4 4 CD cord-005453-4057qib7 8567 16 XIAP xiap NN cord-005453-4057qib7 8567 17 deficiency deficiency NN cord-005453-4057qib7 8567 18 , , , cord-005453-4057qib7 8567 19 and and CC cord-005453-4057qib7 8567 20 1 1 CD cord-005453-4057qib7 8567 21 EDA EDA NNP cord-005453-4057qib7 8567 22 ) ) -RRB- cord-005453-4057qib7 8567 23 . . . cord-005453-4057qib7 8568 1 Anti anti JJ cord-005453-4057qib7 8568 2 - - JJ cord-005453-4057qib7 8568 3 thymocyte thymocyte JJ cord-005453-4057qib7 8568 4 globulin globulin NN cord-005453-4057qib7 8568 5 was be VBD cord-005453-4057qib7 8568 6 used use VBN cord-005453-4057qib7 8568 7 in in IN cord-005453-4057qib7 8568 8 8 8 CD cord-005453-4057qib7 8568 9 patients patient NNS cord-005453-4057qib7 8568 10 of of IN cord-005453-4057qib7 8568 11 FluBU FluBU NNP cord-005453-4057qib7 8568 12 group group NN cord-005453-4057qib7 8568 13 and and CC cord-005453-4057qib7 8568 14 7 7 CD cord-005453-4057qib7 8568 15 patients patient NNS cord-005453-4057qib7 8568 16 of of IN cord-005453-4057qib7 8568 17 FluMel FluMel NNP cord-005453-4057qib7 8568 18 group group NN cord-005453-4057qib7 8568 19 . . . cord-005453-4057qib7 8569 1 Cord cord NN cord-005453-4057qib7 8569 2 blood blood NN cord-005453-4057qib7 8569 3 in in IN cord-005453-4057qib7 8569 4 21 21 CD cord-005453-4057qib7 8569 5 and and CC cord-005453-4057qib7 8569 6 bone bone NN cord-005453-4057qib7 8569 7 marrow marrow NN cord-005453-4057qib7 8569 8 in in IN cord-005453-4057qib7 8569 9 21 21 CD cord-005453-4057qib7 8569 10 was be VBD cord-005453-4057qib7 8569 11 used use VBN cord-005453-4057qib7 8569 12 for for IN cord-005453-4057qib7 8569 13 donor donor NN cord-005453-4057qib7 8569 14 sources source NNS cord-005453-4057qib7 8569 15 . . . cord-005453-4057qib7 8570 1 Matched matched JJ cord-005453-4057qib7 8570 2 donor donor NN cord-005453-4057qib7 8570 3 was be VBD cord-005453-4057qib7 8570 4 used use VBN cord-005453-4057qib7 8570 5 for for IN cord-005453-4057qib7 8570 6 7 7 CD cord-005453-4057qib7 8570 7 and and CC cord-005453-4057qib7 8570 8 8 8 CD cord-005453-4057qib7 8570 9 patients patient NNS cord-005453-4057qib7 8570 10 in in IN cord-005453-4057qib7 8570 11 FluBU FluBU NNP cord-005453-4057qib7 8570 12 and and CC cord-005453-4057qib7 8570 13 FluMel FluMel NNP cord-005453-4057qib7 8570 14 groups group NNS cord-005453-4057qib7 8570 15 ( ( -LRB- cord-005453-4057qib7 8570 16 30.4 30.4 CD cord-005453-4057qib7 8570 17 % % NN cord-005453-4057qib7 8570 18 and and CC cord-005453-4057qib7 8570 19 42.1 42.1 CD cord-005453-4057qib7 8570 20 % % NN cord-005453-4057qib7 8570 21 ) ) -RRB- cord-005453-4057qib7 8570 22 , , , cord-005453-4057qib7 8570 23 respectively respectively RB cord-005453-4057qib7 8570 24 . . . cord-005453-4057qib7 8571 1 Median median JJ cord-005453-4057qib7 8571 2 follow follow VBP cord-005453-4057qib7 8571 3 up up RP cord-005453-4057qib7 8571 4 period period NN cord-005453-4057qib7 8571 5 was be VBD cord-005453-4057qib7 8571 6 2.2 2.2 CD cord-005453-4057qib7 8571 7 years year NNS cord-005453-4057qib7 8571 8 . . . cord-005453-4057qib7 8572 1 Two two CD cord-005453-4057qib7 8572 2 years year NNS cord-005453-4057qib7 8572 3 - - HYPH cord-005453-4057qib7 8572 4 OS os NN cord-005453-4057qib7 8572 5 of of IN cord-005453-4057qib7 8572 6 all all DT cord-005453-4057qib7 8572 7 patients patient NNS cord-005453-4057qib7 8572 8 , , , cord-005453-4057qib7 8572 9 FluBU flubu JJ cord-005453-4057qib7 8572 10 group group NN cord-005453-4057qib7 8572 11 patients patient NNS cord-005453-4057qib7 8572 12 and and CC cord-005453-4057qib7 8572 13 FluMel FluMel NNP cord-005453-4057qib7 8572 14 group group NN cord-005453-4057qib7 8572 15 patients patient NNS cord-005453-4057qib7 8572 16 was be VBD cord-005453-4057qib7 8572 17 79.6 79.6 CD cord-005453-4057qib7 8572 18 % % NN cord-005453-4057qib7 8572 19 , , , cord-005453-4057qib7 8572 20 89.8 89.8 CD cord-005453-4057qib7 8572 21 % % NN cord-005453-4057qib7 8572 22 and and CC cord-005453-4057qib7 8572 23 64.1 64.1 CD cord-005453-4057qib7 8572 24 % % NN cord-005453-4057qib7 8572 25 , , , cord-005453-4057qib7 8572 26 respectively respectively RB cord-005453-4057qib7 8572 27 . . . cord-005453-4057qib7 8573 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 8573 2 engraftment engraftment NN cord-005453-4057qib7 8573 3 was be VBD cord-005453-4057qib7 8573 4 92.9 92.9 CD cord-005453-4057qib7 8573 5 % % NN cord-005453-4057qib7 8573 6 , , , cord-005453-4057qib7 8573 7 91.3 91.3 CD cord-005453-4057qib7 8573 8 % % NN cord-005453-4057qib7 8573 9 and and CC cord-005453-4057qib7 8573 10 94.7 94.7 CD cord-005453-4057qib7 8573 11 % % NN cord-005453-4057qib7 8573 12 ( ( -LRB- cord-005453-4057qib7 8573 13 all all DT cord-005453-4057qib7 8573 14 patients patient NNS cord-005453-4057qib7 8573 15 , , , cord-005453-4057qib7 8573 16 FluBU FluBU NNP cord-005453-4057qib7 8573 17 group group NN cord-005453-4057qib7 8573 18 and and CC cord-005453-4057qib7 8573 19 FluMel FluMel NNP cord-005453-4057qib7 8573 20 group group NN cord-005453-4057qib7 8573 21 ) ) -RRB- cord-005453-4057qib7 8573 22 . . . cord-005453-4057qib7 8574 1 In in IN cord-005453-4057qib7 8574 2 SCID SCID NNP cord-005453-4057qib7 8574 3 , , , cord-005453-4057qib7 8574 4 all all DT cord-005453-4057qib7 8574 5 7 7 CD cord-005453-4057qib7 8574 6 patients patient NNS cord-005453-4057qib7 8574 7 in in IN cord-005453-4057qib7 8574 8 FluBU FluBU NNP cord-005453-4057qib7 8574 9 group group NN cord-005453-4057qib7 8574 10 achieved achieve VBD cord-005453-4057qib7 8574 11 engraftment engraftment NN cord-005453-4057qib7 8574 12 and and CC cord-005453-4057qib7 8574 13 survived survive VBD cord-005453-4057qib7 8574 14 . . . cord-005453-4057qib7 8575 1 Seven seven CD cord-005453-4057qib7 8575 2 out out IN cord-005453-4057qib7 8575 3 of of IN cord-005453-4057qib7 8575 4 8 8 CD cord-005453-4057qib7 8575 5 in in IN cord-005453-4057qib7 8575 6 FluMel FluMel NNP cord-005453-4057qib7 8575 7 group group NN cord-005453-4057qib7 8575 8 achieved achieve VBD cord-005453-4057qib7 8575 9 engraftment engraftment NN cord-005453-4057qib7 8575 10 , , , cord-005453-4057qib7 8575 11 but but CC cord-005453-4057qib7 8575 12 1 1 CD cord-005453-4057qib7 8575 13 patient patient NN cord-005453-4057qib7 8575 14 had have VBD cord-005453-4057qib7 8575 15 secondary secondary JJ cord-005453-4057qib7 8575 16 graft graft NN cord-005453-4057qib7 8575 17 failure failure NN cord-005453-4057qib7 8575 18 and and CC cord-005453-4057qib7 8575 19 3 3 CD cord-005453-4057qib7 8575 20 patients patient NNS cord-005453-4057qib7 8575 21 died die VBD cord-005453-4057qib7 8575 22 . . . cord-005453-4057qib7 8576 1 In in IN cord-005453-4057qib7 8576 2 non non JJ cord-005453-4057qib7 8576 3 - - JJ cord-005453-4057qib7 8576 4 SCID scid JJ cord-005453-4057qib7 8576 5 , , , cord-005453-4057qib7 8576 6 14 14 CD cord-005453-4057qib7 8576 7 out out IN cord-005453-4057qib7 8576 8 of of IN cord-005453-4057qib7 8576 9 16 16 CD cord-005453-4057qib7 8576 10 in in IN cord-005453-4057qib7 8576 11 FluBU FluBU NNP cord-005453-4057qib7 8576 12 group group NN cord-005453-4057qib7 8576 13 achieved achieve VBD cord-005453-4057qib7 8576 14 engraftment engraftment NN cord-005453-4057qib7 8576 15 , , , cord-005453-4057qib7 8576 16 but but CC cord-005453-4057qib7 8576 17 6 6 CD cord-005453-4057qib7 8576 18 patients patient NNS cord-005453-4057qib7 8576 19 had have VBD cord-005453-4057qib7 8576 20 secondary secondary JJ cord-005453-4057qib7 8576 21 graft graft NN cord-005453-4057qib7 8576 22 failure failure NN cord-005453-4057qib7 8576 23 . . . cord-005453-4057qib7 8577 1 All all DT cord-005453-4057qib7 8577 2 11 11 CD cord-005453-4057qib7 8577 3 non non JJ cord-005453-4057qib7 8577 4 - - JJ cord-005453-4057qib7 8577 5 SCID scid JJ cord-005453-4057qib7 8577 6 patients patient NNS cord-005453-4057qib7 8577 7 in in IN cord-005453-4057qib7 8577 8 FluMel FluMel NNP cord-005453-4057qib7 8577 9 group group NN cord-005453-4057qib7 8577 10 were be VBD cord-005453-4057qib7 8577 11 engrafted engraft VBN cord-005453-4057qib7 8577 12 and and CC cord-005453-4057qib7 8577 13 survived survive VBD cord-005453-4057qib7 8577 14 . . . cord-005453-4057qib7 8578 1 Two two CD cord-005453-4057qib7 8578 2 and and CC cord-005453-4057qib7 8578 3 7 7 CD cord-005453-4057qib7 8578 4 patients patient NNS cord-005453-4057qib7 8578 5 in in IN cord-005453-4057qib7 8578 6 FluBU FluBU NNP cord-005453-4057qib7 8578 7 group group NN cord-005453-4057qib7 8578 8 and and CC cord-005453-4057qib7 8578 9 FluMel FluMel NNP cord-005453-4057qib7 8578 10 group group NN cord-005453-4057qib7 8578 11 suffered suffer VBD cord-005453-4057qib7 8578 12 from from IN cord-005453-4057qib7 8578 13 severe severe JJ cord-005453-4057qib7 8578 14 acute acute JJ cord-005453-4057qib7 8578 15 graft graft NN cord-005453-4057qib7 8578 16 - - HYPH cord-005453-4057qib7 8578 17 versus versus IN cord-005453-4057qib7 8578 18 - - HYPH cord-005453-4057qib7 8578 19 host host NN cord-005453-4057qib7 8578 20 disease disease NN cord-005453-4057qib7 8578 21 ( ( -LRB- cord-005453-4057qib7 8578 22 grade grade NN cord-005453-4057qib7 8578 23 III III NNP cord-005453-4057qib7 8578 24 - - HYPH cord-005453-4057qib7 8578 25 IV IV NNP cord-005453-4057qib7 8578 26 ) ) -RRB- cord-005453-4057qib7 8578 27 . . . cord-005453-4057qib7 8579 1 Ten ten CD cord-005453-4057qib7 8579 2 patients patient NNS cord-005453-4057qib7 8579 3 had have VBD cord-005453-4057qib7 8579 4 hemophagocytic hemophagocytic JJ cord-005453-4057qib7 8579 5 lymphohistiocytosis lymphohistiocytosis NN cord-005453-4057qib7 8579 6 ( ( -LRB- cord-005453-4057qib7 8579 7 HLH HLH NNP cord-005453-4057qib7 8579 8 ) ) -RRB- cord-005453-4057qib7 8579 9 . . . cord-005453-4057qib7 8580 1 Viral viral JJ cord-005453-4057qib7 8580 2 reactivation reactivation NN cord-005453-4057qib7 8580 3 or or CC cord-005453-4057qib7 8580 4 infection infection NN cord-005453-4057qib7 8580 5 was be VBD cord-005453-4057qib7 8580 6 observed observe VBN cord-005453-4057qib7 8580 7 in in IN cord-005453-4057qib7 8580 8 20 20 CD cord-005453-4057qib7 8580 9 patients patient NNS cord-005453-4057qib7 8580 10 , , , cord-005453-4057qib7 8580 11 and and CC cord-005453-4057qib7 8580 12 resolved resolve VBN cord-005453-4057qib7 8580 13 in in IN cord-005453-4057qib7 8580 14 all all DT cord-005453-4057qib7 8580 15 but but IN cord-005453-4057qib7 8580 16 one one CD cord-005453-4057qib7 8580 17 patient patient NN cord-005453-4057qib7 8580 18 . . . cord-005453-4057qib7 8581 1 Conclusions conclusion NNS cord-005453-4057qib7 8581 2 : : : cord-005453-4057qib7 8582 1 The the DT cord-005453-4057qib7 8582 2 RIC RIC NNP cord-005453-4057qib7 8582 3 - - HYPH cord-005453-4057qib7 8582 4 HCT HCT NNP cord-005453-4057qib7 8582 5 using use VBG cord-005453-4057qib7 8582 6 FluBU FluBU NNP cord-005453-4057qib7 8582 7 or or CC cord-005453-4057qib7 8582 8 FluMel FluMel NNP cord-005453-4057qib7 8582 9 was be VBD cord-005453-4057qib7 8582 10 advantagous advantagous JJ cord-005453-4057qib7 8582 11 for for IN cord-005453-4057qib7 8582 12 neutrophil neutrophil NN cord-005453-4057qib7 8582 13 engraftment engraftment NN cord-005453-4057qib7 8582 14 , , , cord-005453-4057qib7 8582 15 and and CC cord-005453-4057qib7 8582 16 FluBU FluBU NNP cord-005453-4057qib7 8582 17 for for IN cord-005453-4057qib7 8582 18 SCID SCID NNP cord-005453-4057qib7 8582 19 and and CC cord-005453-4057qib7 8582 20 FluMel FluMel NNP cord-005453-4057qib7 8582 21 for for IN cord-005453-4057qib7 8582 22 CID CID NNP cord-005453-4057qib7 8582 23 with with IN cord-005453-4057qib7 8582 24 immune immune JJ cord-005453-4057qib7 8582 25 dysregulation dysregulation NN cord-005453-4057qib7 8582 26 may may MD cord-005453-4057qib7 8582 27 be be VB cord-005453-4057qib7 8582 28 an an DT cord-005453-4057qib7 8582 29 effective effective JJ cord-005453-4057qib7 8582 30 opinion opinion NN cord-005453-4057qib7 8582 31 . . . cord-005453-4057qib7 8583 1 FluBU flubu JJ cord-005453-4057qib7 8583 2 regimen regimen NN cord-005453-4057qib7 8583 3 needs need VBZ cord-005453-4057qib7 8583 4 to to TO cord-005453-4057qib7 8583 5 be be VB cord-005453-4057qib7 8583 6 improved improve VBN cord-005453-4057qib7 8583 7 for for IN cord-005453-4057qib7 8583 8 secondary secondary JJ cord-005453-4057qib7 8583 9 graft graft NN cord-005453-4057qib7 8583 10 failure failure NN cord-005453-4057qib7 8583 11 in in IN cord-005453-4057qib7 8583 12 non non JJ cord-005453-4057qib7 8583 13 - - JJ cord-005453-4057qib7 8583 14 SCID scid JJ cord-005453-4057qib7 8583 15 . . . cord-005453-4057qib7 8584 1 Prevention prevention NN cord-005453-4057qib7 8584 2 of of IN cord-005453-4057qib7 8584 3 HLH HLH NNP cord-005453-4057qib7 8584 4 after after IN cord-005453-4057qib7 8584 5 transplantation transplantation NN cord-005453-4057qib7 8584 6 using use VBG cord-005453-4057qib7 8584 7 dexamethasone dexamethasone NN cord-005453-4057qib7 8584 8 palmitate palmitate NN cord-005453-4057qib7 8584 9 will will MD cord-005453-4057qib7 8584 10 be be VB cord-005453-4057qib7 8584 11 considered consider VBN cord-005453-4057qib7 8584 12 . . . cord-005453-4057qib7 8585 1 Disclosure disclosure NN cord-005453-4057qib7 8585 2 : : : cord-005453-4057qib7 8585 3 Nothing nothing NN cord-005453-4057qib7 8585 4 to to TO cord-005453-4057qib7 8585 5 declare declare VB cord-005453-4057qib7 8585 6 . . . cord-005453-4057qib7 8586 1 Survival survival NN cord-005453-4057qib7 8586 2 after after IN cord-005453-4057qib7 8586 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 8586 4 stem stem NN cord-005453-4057qib7 8586 5 cell cell NN cord-005453-4057qib7 8586 6 transplantation transplantation NN cord-005453-4057qib7 8586 7 with with IN cord-005453-4057qib7 8587 1 TCRαβ TCRαβ NNP cord-005453-4057qib7 8587 2 / / SYM cord-005453-4057qib7 8587 3 CD19 CD19 NNP cord-005453-4057qib7 8587 4 graft graft NN cord-005453-4057qib7 8587 5 depletion depletion NN cord-005453-4057qib7 8587 6 in in IN cord-005453-4057qib7 8587 7 older old JJR cord-005453-4057qib7 8587 8 children child NNS cord-005453-4057qib7 8587 9 with with IN cord-005453-4057qib7 8587 10 primary primary JJ cord-005453-4057qib7 8587 11 immunodeficiencies immunodeficiency NNS cord-005453-4057qib7 8588 1 Background background NN cord-005453-4057qib7 8588 2 : : : cord-005453-4057qib7 8589 1 TCRαβ/ tcrαβ/ ADD cord-005453-4057qib7 8590 1 CD19 CD19 NNP cord-005453-4057qib7 8590 2 depletion depletion NN cord-005453-4057qib7 8590 3 is be VBZ cord-005453-4057qib7 8590 4 a a DT cord-005453-4057qib7 8590 5 graft graft NN cord-005453-4057qib7 8590 6 engineering engineering NN cord-005453-4057qib7 8590 7 method method NN cord-005453-4057qib7 8590 8 that that WDT cord-005453-4057qib7 8590 9 proved prove VBD cord-005453-4057qib7 8590 10 valuable valuable JJ cord-005453-4057qib7 8590 11 in in IN cord-005453-4057qib7 8590 12 increasing increase VBG cord-005453-4057qib7 8590 13 the the DT cord-005453-4057qib7 8590 14 survival survival NN cord-005453-4057qib7 8590 15 rate rate NN cord-005453-4057qib7 8590 16 after after IN cord-005453-4057qib7 8590 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 8590 18 stem stem NN cord-005453-4057qib7 8590 19 cell cell NN cord-005453-4057qib7 8590 20 transplantation transplantation NN cord-005453-4057qib7 8590 21 ( ( -LRB- cord-005453-4057qib7 8590 22 HSCT HSCT NNP cord-005453-4057qib7 8590 23 ) ) -RRB- cord-005453-4057qib7 8590 24 in in IN cord-005453-4057qib7 8590 25 patients patient NNS cord-005453-4057qib7 8590 26 with with IN cord-005453-4057qib7 8590 27 primary primary JJ cord-005453-4057qib7 8590 28 immunodeficiencies immunodeficiency NNS cord-005453-4057qib7 8590 29 ( ( -LRB- cord-005453-4057qib7 8590 30 PID PID NNP cord-005453-4057qib7 8590 31 ) ) -RRB- cord-005453-4057qib7 8590 32 . . . cord-005453-4057qib7 8591 1 Decreased decrease VBN cord-005453-4057qib7 8591 2 survival survival NN cord-005453-4057qib7 8591 3 rate rate NN cord-005453-4057qib7 8591 4 in in IN cord-005453-4057qib7 8591 5 older old JJR cord-005453-4057qib7 8591 6 patients patient NNS cord-005453-4057qib7 8591 7 with with IN cord-005453-4057qib7 8591 8 PID PID NNP cord-005453-4057qib7 8591 9 was be VBD cord-005453-4057qib7 8591 10 previously previously RB cord-005453-4057qib7 8591 11 reported report VBN cord-005453-4057qib7 8591 12 after after IN cord-005453-4057qib7 8591 13 transplantations transplantation NNS cord-005453-4057qib7 8591 14 with with IN cord-005453-4057qib7 8591 15 nonmanipulated nonmanipulate VBN cord-005453-4057qib7 8591 16 grafts graft NNS cord-005453-4057qib7 8591 17 . . . cord-005453-4057qib7 8592 1 Methods method NNS cord-005453-4057qib7 8592 2 : : : cord-005453-4057qib7 8592 3 148 148 CD cord-005453-4057qib7 8592 4 patients patient NNS cord-005453-4057qib7 8592 5 with with IN cord-005453-4057qib7 8592 6 various various JJ cord-005453-4057qib7 8592 7 PID pid NN cord-005453-4057qib7 8592 8 ( ( -LRB- cord-005453-4057qib7 8592 9 excluding exclude VBG cord-005453-4057qib7 8592 10 classic classic JJ cord-005453-4057qib7 8592 11 SCID SCID NNP cord-005453-4057qib7 8592 12 ) ) -RRB- cord-005453-4057qib7 8592 13 who who WP cord-005453-4057qib7 8592 14 received receive VBD cord-005453-4057qib7 8592 15 allogenic allogenic JJ cord-005453-4057qib7 8592 16 HSCT HSCT NNP cord-005453-4057qib7 8592 17 with with IN cord-005453-4057qib7 8592 18 TCRαβ/ TCRαβ/ NNP cord-005453-4057qib7 8592 19 CD19 CD19 NNP cord-005453-4057qib7 8592 20 graft graft NN cord-005453-4057qib7 8592 21 depletion depletion NN cord-005453-4057qib7 8592 22 from from IN cord-005453-4057qib7 8592 23 2012 2012 CD cord-005453-4057qib7 8592 24 to to IN cord-005453-4057qib7 8592 25 September September NNP cord-005453-4057qib7 8592 26 2018 2018 CD cord-005453-4057qib7 8592 27 in in IN cord-005453-4057qib7 8592 28 our -PRON- PRP$ cord-005453-4057qib7 8592 29 center center NN cord-005453-4057qib7 8592 30 were be VBD cord-005453-4057qib7 8592 31 analyzed analyze VBN cord-005453-4057qib7 8592 32 . . . cord-005453-4057qib7 8593 1 The the DT cord-005453-4057qib7 8593 2 median median JJ cord-005453-4057qib7 8593 3 age age NN cord-005453-4057qib7 8593 4 at at IN cord-005453-4057qib7 8593 5 HSCT HSCT NNP cord-005453-4057qib7 8593 6 was be VBD cord-005453-4057qib7 8593 7 3,5 3,5 CD cord-005453-4057qib7 8593 8 years year NNS cord-005453-4057qib7 8594 1 ( ( -LRB- cord-005453-4057qib7 8594 2 range range VB cord-005453-4057qib7 8594 3 0,43 0,43 CD cord-005453-4057qib7 8594 4 - - HYPH cord-005453-4057qib7 8594 5 17,63 17,63 CD cord-005453-4057qib7 8594 6 ) ) -RRB- cord-005453-4057qib7 8594 7 . . . cord-005453-4057qib7 8595 1 Patients patient NNS cord-005453-4057qib7 8595 2 were be VBD cord-005453-4057qib7 8595 3 divided divide VBN cord-005453-4057qib7 8595 4 into into IN cord-005453-4057qib7 8595 5 3 3 CD cord-005453-4057qib7 8595 6 age age NN cord-005453-4057qib7 8595 7 groups group NNS cord-005453-4057qib7 8595 8 : : : cord-005453-4057qib7 8595 9 0 0 CD cord-005453-4057qib7 8595 10 - - SYM cord-005453-4057qib7 8595 11 6 6 CD cord-005453-4057qib7 8595 12 years year NNS cord-005453-4057qib7 8595 13 -95 -95 NN cord-005453-4057qib7 8595 14 patients patient NNS cord-005453-4057qib7 8595 15 , , , cord-005453-4057qib7 8595 16 6 6 CD cord-005453-4057qib7 8595 17 - - SYM cord-005453-4057qib7 8595 18 12 12 CD cord-005453-4057qib7 8595 19 years year NNS cord-005453-4057qib7 8595 20 -30 -30 NN cord-005453-4057qib7 8595 21 , , , cord-005453-4057qib7 8595 22 12 12 CD cord-005453-4057qib7 8595 23 - - SYM cord-005453-4057qib7 8595 24 18 18 CD cord-005453-4057qib7 8595 25 years year NNS cord-005453-4057qib7 8595 26 -23 -23 NN cord-005453-4057qib7 8595 27 . . . cord-005453-4057qib7 8596 1 112 112 CD cord-005453-4057qib7 8596 2 patients patient NNS cord-005453-4057qib7 8596 3 received receive VBD cord-005453-4057qib7 8596 4 HSCT HSCT NNP cord-005453-4057qib7 8596 5 from from IN cord-005453-4057qib7 8596 6 matched match VBN cord-005453-4057qib7 8596 7 unrelated unrelated JJ cord-005453-4057qib7 8596 8 , , , cord-005453-4057qib7 8596 9 31 31 CD cord-005453-4057qib7 8596 10 -haploidentical -haploidentical JJ cord-005453-4057qib7 8596 11 donors donor NNS cord-005453-4057qib7 8596 12 , , , cord-005453-4057qib7 8596 13 5 5 CD cord-005453-4057qib7 8596 14 -siblings -sibling NNS cord-005453-4057qib7 8596 15 . . . cord-005453-4057qib7 8597 1 Conditioning conditioning NN cord-005453-4057qib7 8597 2 regimens regimen NNS cord-005453-4057qib7 8597 3 with with IN cord-005453-4057qib7 8597 4 1 1 CD cord-005453-4057qib7 8597 5 - - SYM cord-005453-4057qib7 8597 6 2 2 CD cord-005453-4057qib7 8597 7 alkylating alkylating JJ cord-005453-4057qib7 8597 8 agents agent NNS cord-005453-4057qib7 8597 9 and and CC cord-005453-4057qib7 8597 10 antithymocyte antithymocyte NNP cord-005453-4057qib7 8597 11 globulin globulin NNP cord-005453-4057qib7 8597 12 were be VBD cord-005453-4057qib7 8597 13 used use VBN cord-005453-4057qib7 8597 14 in in IN cord-005453-4057qib7 8597 15 all all DT cord-005453-4057qib7 8597 16 patients patient NNS cord-005453-4057qib7 8597 17 . . . cord-005453-4057qib7 8598 1 113 113 CD cord-005453-4057qib7 8598 2 patient patient NN cord-005453-4057qib7 8598 3 received receive VBD cord-005453-4057qib7 8598 4 short short JJ cord-005453-4057qib7 8598 5 courses course NNS cord-005453-4057qib7 8598 6 of of IN cord-005453-4057qib7 8598 7 various various JJ cord-005453-4057qib7 8598 8 posttransplant posttransplant NN cord-005453-4057qib7 8598 9 immunosuppressants immunosuppressant NNS cord-005453-4057qib7 8598 10 . . . cord-005453-4057qib7 8599 1 Median median JJ cord-005453-4057qib7 8599 2 follow follow VBP cord-005453-4057qib7 8599 3 up up RP cord-005453-4057qib7 8599 4 after after IN cord-005453-4057qib7 8599 5 HSCT HSCT NNP cord-005453-4057qib7 8599 6 is be VBZ cord-005453-4057qib7 8599 7 1,95 1,95 CD cord-005453-4057qib7 8599 8 years year NNS cord-005453-4057qib7 8600 1 ( ( -LRB- cord-005453-4057qib7 8600 2 range range NNP cord-005453-4057qib7 8600 3 0,04 0,04 CD cord-005453-4057qib7 8600 4 - - HYPH cord-005453-4057qib7 8600 5 6,3 6,3 CD cord-005453-4057qib7 8600 6 years year NNS cord-005453-4057qib7 8600 7 ) ) -RRB- cord-005453-4057qib7 8600 8 . . . cord-005453-4057qib7 8601 1 Results result NNS cord-005453-4057qib7 8601 2 : : : cord-005453-4057qib7 8602 1 Overall overall JJ cord-005453-4057qib7 8602 2 survival survival NN cord-005453-4057qib7 8602 3 ( ( -LRB- cord-005453-4057qib7 8602 4 OS OS NNP cord-005453-4057qib7 8602 5 ) ) -RRB- cord-005453-4057qib7 8602 6 in in IN cord-005453-4057qib7 8602 7 148 148 CD cord-005453-4057qib7 8602 8 patients patient NNS cord-005453-4057qib7 8602 9 was be VBD cord-005453-4057qib7 8602 10 0,85 0,85 CD cord-005453-4057qib7 8602 11 ( ( -LRB- cord-005453-4057qib7 8602 12 95 95 CD cord-005453-4057qib7 8602 13 % % NN cord-005453-4057qib7 8602 14 CI CI NNP cord-005453-4057qib7 8602 15 0,79 0,79 CD cord-005453-4057qib7 8602 16 - - HYPH cord-005453-4057qib7 8602 17 0,91 0,91 CD cord-005453-4057qib7 8602 18 ) ) -RRB- cord-005453-4057qib7 8602 19 . . . cord-005453-4057qib7 8603 1 We -PRON- PRP cord-005453-4057qib7 8603 2 observed observe VBD cord-005453-4057qib7 8603 3 similar similar JJ cord-005453-4057qib7 8603 4 OS os NN cord-005453-4057qib7 8603 5 in in IN cord-005453-4057qib7 8603 6 the the DT cord-005453-4057qib7 8603 7 younger young JJR cord-005453-4057qib7 8603 8 age age NN cord-005453-4057qib7 8603 9 groups group NNS cord-005453-4057qib7 8603 10 : : : cord-005453-4057qib7 8603 11 0,89 0,89 CD cord-005453-4057qib7 8603 12 ( ( -LRB- cord-005453-4057qib7 8603 13 95 95 CD cord-005453-4057qib7 8603 14 % % NN cord-005453-4057qib7 8603 15 CI CI NNP cord-005453-4057qib7 8603 16 0,83 0,83 CD cord-005453-4057qib7 8603 17 - - HYPH cord-005453-4057qib7 8603 18 0,96 0,96 CD cord-005453-4057qib7 8603 19 ) ) -RRB- cord-005453-4057qib7 8603 20 in in IN cord-005453-4057qib7 8603 21 0 0 CD cord-005453-4057qib7 8603 22 - - SYM cord-005453-4057qib7 8603 23 6 6 CD cord-005453-4057qib7 8603 24 years year NNS cord-005453-4057qib7 8603 25 and and CC cord-005453-4057qib7 8603 26 0,89 0,89 CD cord-005453-4057qib7 8603 27 ( ( -LRB- cord-005453-4057qib7 8603 28 95 95 CD cord-005453-4057qib7 8603 29 % % NN cord-005453-4057qib7 8603 30 CI CI NNP cord-005453-4057qib7 8603 31 0,78 0,78 NNP cord-005453-4057qib7 8603 32 - - HYPH cord-005453-4057qib7 8603 33 1,0 1,0 CD cord-005453-4057qib7 8603 34 ) ) -RRB- cord-005453-4057qib7 8603 35 in in IN cord-005453-4057qib7 8603 36 6 6 CD cord-005453-4057qib7 8603 37 - - SYM cord-005453-4057qib7 8603 38 12 12 CD cord-005453-4057qib7 8603 39 years year NNS cord-005453-4057qib7 8603 40 of of IN cord-005453-4057qib7 8603 41 age age NN cord-005453-4057qib7 8603 42 . . . cord-005453-4057qib7 8604 1 Seven seven CD cord-005453-4057qib7 8604 2 of of IN cord-005453-4057qib7 8604 3 23 23 CD cord-005453-4057qib7 8604 4 patients patient NNS cord-005453-4057qib7 8604 5 in in IN cord-005453-4057qib7 8604 6 older old JJR cord-005453-4057qib7 8604 7 group group NN cord-005453-4057qib7 8604 8 ( ( -LRB- cord-005453-4057qib7 8604 9 12 12 CD cord-005453-4057qib7 8604 10 - - SYM cord-005453-4057qib7 8604 11 18 18 CD cord-005453-4057qib7 8604 12 years year NNS cord-005453-4057qib7 8604 13 of of IN cord-005453-4057qib7 8604 14 age age NN cord-005453-4057qib7 8604 15 ) ) -RRB- cord-005453-4057qib7 8604 16 died die VBD cord-005453-4057qib7 8604 17 , , , cord-005453-4057qib7 8604 18 the the DT cord-005453-4057qib7 8604 19 OS OS NNP cord-005453-4057qib7 8604 20 was be VBD cord-005453-4057qib7 8604 21 only only RB cord-005453-4057qib7 8604 22 0,65 0,65 CD cord-005453-4057qib7 8605 1 ( ( -LRB- cord-005453-4057qib7 8605 2 95 95 CD cord-005453-4057qib7 8605 3 % % NN cord-005453-4057qib7 8605 4 CI CI NNP cord-005453-4057qib7 8605 5 0,43 0,43 CD cord-005453-4057qib7 8605 6 - - HYPH cord-005453-4057qib7 8605 7 0,86 0,86 CD cord-005453-4057qib7 8605 8 ) ) -RRB- cord-005453-4057qib7 8605 9 , , , cord-005453-4057qib7 8605 10 p=0,065 p=0,065 NNP cord-005453-4057qib7 8605 11 . . . cord-005453-4057qib7 8606 1 All all DT cord-005453-4057qib7 8606 2 patients patient NNS cord-005453-4057qib7 8606 3 from from IN cord-005453-4057qib7 8606 4 older old JJR cord-005453-4057qib7 8606 5 age age NN cord-005453-4057qib7 8606 6 group group NN cord-005453-4057qib7 8606 7 who who WP cord-005453-4057qib7 8606 8 died die VBD cord-005453-4057qib7 8606 9 had have VBD cord-005453-4057qib7 8606 10 combined combine VBN cord-005453-4057qib7 8606 11 PID pid NN cord-005453-4057qib7 8606 12 : : : cord-005453-4057qib7 8606 13 1 1 CD cord-005453-4057qib7 8606 14 -Wiscott -Wiscott NNP cord-005453-4057qib7 8606 15 - - HYPH cord-005453-4057qib7 8606 16 Aldrich Aldrich NNP cord-005453-4057qib7 8606 17 syndrome syndrome NN cord-005453-4057qib7 8606 18 , , , cord-005453-4057qib7 8606 19 1 1 CD cord-005453-4057qib7 8606 20 -undefined -undefine VBN cord-005453-4057qib7 8606 21 PID PID NNP cord-005453-4057qib7 8606 22 , , , cord-005453-4057qib7 8606 23 1 1 CD cord-005453-4057qib7 8606 24 -IL2RG -IL2RG NNP cord-005453-4057qib7 8606 25 deficiency deficiency NN cord-005453-4057qib7 8606 26 , , , cord-005453-4057qib7 8606 27 1 1 CD cord-005453-4057qib7 8606 28 -DCLRE1C -dclre1c NN cord-005453-4057qib7 8606 29 deficiency deficiency NN cord-005453-4057qib7 8606 30 , , , cord-005453-4057qib7 8606 31 1 1 CD cord-005453-4057qib7 8606 32 -Nijmegen -nijmegen IN cord-005453-4057qib7 8606 33 breakage breakage NN cord-005453-4057qib7 8606 34 syndrome syndrome NN cord-005453-4057qib7 8606 35 ( ( -LRB- cord-005453-4057qib7 8606 36 NBS NBS NNP cord-005453-4057qib7 8606 37 ) ) -RRB- cord-005453-4057qib7 8606 38 , , , cord-005453-4057qib7 8606 39 1 1 CD cord-005453-4057qib7 8606 40 -Kabuki -Kabuki NNP cord-005453-4057qib7 8606 41 syndrome syndrome NN cord-005453-4057qib7 8606 42 , , , cord-005453-4057qib7 8606 43 1 1 CD cord-005453-4057qib7 8606 44 -ICF -icf DT cord-005453-4057qib7 8606 45 syndrome syndrome NN cord-005453-4057qib7 8606 46 . . . cord-005453-4057qib7 8607 1 The the DT cord-005453-4057qib7 8607 2 median median JJ cord-005453-4057qib7 8607 3 time time NN cord-005453-4057qib7 8607 4 of of IN cord-005453-4057qib7 8607 5 death death NN cord-005453-4057qib7 8607 6 after after IN cord-005453-4057qib7 8607 7 HSCT HSCT NNP cord-005453-4057qib7 8607 8 was be VBD cord-005453-4057qib7 8607 9 0,64 0,64 CD cord-005453-4057qib7 8607 10 years year NNS cord-005453-4057qib7 8607 11 ( ( -LRB- cord-005453-4057qib7 8607 12 range range VBP cord-005453-4057qib7 8607 13 0,26 0,26 CD cord-005453-4057qib7 8607 14 -1,58 -1,58 NFP cord-005453-4057qib7 8607 15 ) ) -RRB- cord-005453-4057qib7 8607 16 . . . cord-005453-4057qib7 8608 1 Six six CD cord-005453-4057qib7 8608 2 of of IN cord-005453-4057qib7 8608 3 those those DT cord-005453-4057qib7 8608 4 had have VBD cord-005453-4057qib7 8608 5 transplant transplant NN cord-005453-4057qib7 8608 6 - - HYPH cord-005453-4057qib7 8608 7 related relate VBN cord-005453-4057qib7 8608 8 mortality mortality NN cord-005453-4057qib7 8608 9 ( ( -LRB- cord-005453-4057qib7 8608 10 TRM TRM NNP cord-005453-4057qib7 8608 11 ) ) -RRB- cord-005453-4057qib7 8608 12 . . . cord-005453-4057qib7 8609 1 Five five CD cord-005453-4057qib7 8609 2 patients patient NNS cord-005453-4057qib7 8609 3 had have VBD cord-005453-4057qib7 8609 4 HSCT HSCT NNP cord-005453-4057qib7 8609 5 - - HYPH cord-005453-4057qib7 8609 6 associated associate VBN cord-005453-4057qib7 8609 7 viral viral JJ cord-005453-4057qib7 8609 8 infections infection NNS cord-005453-4057qib7 8609 9 : : : cord-005453-4057qib7 8609 10 2 2 CD cord-005453-4057qib7 8609 11 -CMV -CMV : cord-005453-4057qib7 8609 12 pneumonias pneumonia NNS cord-005453-4057qib7 8609 13 , , , cord-005453-4057qib7 8609 14 3 3 CD cord-005453-4057qib7 8609 15 -ADV -ADV : cord-005453-4057qib7 8609 16 infections infection NNS cord-005453-4057qib7 8609 17 ( ( -LRB- cord-005453-4057qib7 8609 18 1 1 CD cord-005453-4057qib7 8609 19 -fulminant -fulminant JJ cord-005453-4057qib7 8609 20 hepatitis hepatitis NN cord-005453-4057qib7 8609 21 , , , cord-005453-4057qib7 8609 22 2 2 CD cord-005453-4057qib7 8609 23 -multiorgan -multiorgan CD cord-005453-4057qib7 8609 24 ) ) -RRB- cord-005453-4057qib7 8609 25 . . . cord-005453-4057qib7 8610 1 Interestingly interestingly RB cord-005453-4057qib7 8610 2 , , , cord-005453-4057qib7 8610 3 2 2 CD cord-005453-4057qib7 8610 4 of of IN cord-005453-4057qib7 8610 5 them -PRON- PRP cord-005453-4057qib7 8610 6 had have VBD cord-005453-4057qib7 8610 7 prolonged prolong VBN cord-005453-4057qib7 8610 8 history history NN cord-005453-4057qib7 8610 9 of of IN cord-005453-4057qib7 8610 10 disseminated disseminate VBN cord-005453-4057qib7 8610 11 viral viral JJ cord-005453-4057qib7 8610 12 infections infection NNS cord-005453-4057qib7 8610 13 ( ( -LRB- cord-005453-4057qib7 8610 14 ADV ADV NNP cord-005453-4057qib7 8610 15 ) ) -RRB- cord-005453-4057qib7 8610 16 , , , cord-005453-4057qib7 8610 17 with with IN cord-005453-4057qib7 8610 18 the the DT cord-005453-4057qib7 8610 19 reduction reduction NN cord-005453-4057qib7 8610 20 of of IN cord-005453-4057qib7 8610 21 viral viral JJ cord-005453-4057qib7 8610 22 load load NN cord-005453-4057qib7 8610 23 in in IN cord-005453-4057qib7 8610 24 blood blood NN cord-005453-4057qib7 8610 25 and and CC cord-005453-4057qib7 8610 26 other other JJ cord-005453-4057qib7 8610 27 fluids fluid NNS cord-005453-4057qib7 8610 28 and and CC cord-005453-4057qib7 8610 29 tissues tissue NNS cord-005453-4057qib7 8610 30 upon upon IN cord-005453-4057qib7 8610 31 treatment treatment NN cord-005453-4057qib7 8610 32 . . . cord-005453-4057qib7 8611 1 One one CD cord-005453-4057qib7 8611 2 patient patient NN cord-005453-4057qib7 8611 3 with with IN cord-005453-4057qib7 8611 4 Kabuki Kabuki NNP cord-005453-4057qib7 8611 5 syndrome syndrome NN cord-005453-4057qib7 8611 6 after after IN cord-005453-4057qib7 8611 7 HSCT HSCT NNP cord-005453-4057qib7 8611 8 developed develop VBD cord-005453-4057qib7 8611 9 HHV8 HHV8 NNP cord-005453-4057qib7 8611 10 associated associate VBD cord-005453-4057qib7 8611 11 Kaposi Kaposi NNP cord-005453-4057qib7 8611 12 sarcoma sarcoma NN cord-005453-4057qib7 8611 13 , , , cord-005453-4057qib7 8611 14 was be VBD cord-005453-4057qib7 8611 15 successfully successfully RB cord-005453-4057qib7 8611 16 treated treat VBN cord-005453-4057qib7 8611 17 . . . cord-005453-4057qib7 8612 1 Eventually eventually RB cord-005453-4057qib7 8612 2 all all DT cord-005453-4057qib7 8612 3 3 3 CD cord-005453-4057qib7 8612 4 patients patient NNS cord-005453-4057qib7 8612 5 with with IN cord-005453-4057qib7 8612 6 reduction reduction NN cord-005453-4057qib7 8612 7 of of IN cord-005453-4057qib7 8612 8 viral viral JJ cord-005453-4057qib7 8612 9 infection infection NN cord-005453-4057qib7 8612 10 and and CC cord-005453-4057qib7 8612 11 sarcoma sarcoma NN cord-005453-4057qib7 8612 12 symptoms symptom NNS cord-005453-4057qib7 8612 13 developed develop VBD cord-005453-4057qib7 8612 14 multiorgan multiorgan NNP cord-005453-4057qib7 8612 15 failure failure NN cord-005453-4057qib7 8612 16 with with IN cord-005453-4057qib7 8612 17 some some DT cord-005453-4057qib7 8612 18 clinical clinical JJ cord-005453-4057qib7 8612 19 and and CC cord-005453-4057qib7 8612 20 laboratory laboratory NN cord-005453-4057qib7 8612 21 evidences evidence NNS cord-005453-4057qib7 8612 22 of of IN cord-005453-4057qib7 8612 23 endothelium endothelium NN cord-005453-4057qib7 8612 24 cell cell NN cord-005453-4057qib7 8612 25 damage damage NN cord-005453-4057qib7 8612 26 syndrome syndrome NN cord-005453-4057qib7 8612 27 . . . cord-005453-4057qib7 8613 1 One one CD cord-005453-4057qib7 8613 2 patient patient NN cord-005453-4057qib7 8613 3 with with IN cord-005453-4057qib7 8613 4 NBS NBS NNP cord-005453-4057qib7 8613 5 died die VBD cord-005453-4057qib7 8613 6 of of IN cord-005453-4057qib7 8613 7 high high JJ cord-005453-4057qib7 8613 8 grade grade NN cord-005453-4057qib7 8613 9 lymphoma lymphoma NN cord-005453-4057qib7 8613 10 progression progression NN cord-005453-4057qib7 8613 11 . . . cord-005453-4057qib7 8614 1 Conclusions conclusion NNS cord-005453-4057qib7 8614 2 : : : cord-005453-4057qib7 8615 1 HSCT HSCT NNP cord-005453-4057qib7 8615 2 with with IN cord-005453-4057qib7 8615 3 TCRαβ TCRαβ NNP cord-005453-4057qib7 8616 1 /CD19 /CD19 NNP cord-005453-4057qib7 8616 2 depletion depletion NN cord-005453-4057qib7 8616 3 demonstrates demonstrate VBZ cord-005453-4057qib7 8616 4 high high JJ cord-005453-4057qib7 8616 5 survival survival NN cord-005453-4057qib7 8616 6 rate rate NN cord-005453-4057qib7 8616 7 in in IN cord-005453-4057qib7 8616 8 148 148 CD cord-005453-4057qib7 8616 9 patients patient NNS cord-005453-4057qib7 8616 10 with with IN cord-005453-4057qib7 8616 11 various various JJ cord-005453-4057qib7 8616 12 PID pid NN cord-005453-4057qib7 8616 13 . . . cord-005453-4057qib7 8617 1 In in IN cord-005453-4057qib7 8617 2 our -PRON- PRP$ cord-005453-4057qib7 8617 3 group group NN cord-005453-4057qib7 8617 4 patients patient NNS cord-005453-4057qib7 8617 5 ' ' POS cord-005453-4057qib7 8617 6 age age NN cord-005453-4057qib7 8617 7 older old JJR cord-005453-4057qib7 8617 8 than than IN cord-005453-4057qib7 8617 9 12 12 CD cord-005453-4057qib7 8617 10 years year NNS cord-005453-4057qib7 8617 11 predisposes predispose VBZ cord-005453-4057qib7 8617 12 to to IN cord-005453-4057qib7 8617 13 decreased decrease VBN cord-005453-4057qib7 8617 14 posttransplant posttransplant JJ cord-005453-4057qib7 8617 15 survival survival NN cord-005453-4057qib7 8617 16 . . . cord-005453-4057qib7 8618 1 Patients patient NNS cord-005453-4057qib7 8618 2 with with IN cord-005453-4057qib7 8618 3 combined combined JJ cord-005453-4057qib7 8618 4 PID pid NN cord-005453-4057qib7 8618 5 are be VBP cord-005453-4057qib7 8618 6 at at IN cord-005453-4057qib7 8618 7 higher high JJR cord-005453-4057qib7 8618 8 risks risk NNS cord-005453-4057qib7 8618 9 of of IN cord-005453-4057qib7 8618 10 posttransplant posttransplant NN cord-005453-4057qib7 8618 11 mortality mortality NN cord-005453-4057qib7 8618 12 . . . cord-005453-4057qib7 8619 1 We -PRON- PRP cord-005453-4057qib7 8619 2 conclude conclude VBP cord-005453-4057qib7 8619 3 that that IN cord-005453-4057qib7 8619 4 at at IN cord-005453-4057qib7 8619 5 least least JJS cord-005453-4057qib7 8619 6 in in IN cord-005453-4057qib7 8619 7 some some DT cord-005453-4057qib7 8619 8 of of IN cord-005453-4057qib7 8619 9 our -PRON- PRP$ cord-005453-4057qib7 8619 10 patients patient NNS cord-005453-4057qib7 8619 11 with with IN cord-005453-4057qib7 8619 12 prolonged prolonged JJ cord-005453-4057qib7 8619 13 history history NN cord-005453-4057qib7 8619 14 of of IN cord-005453-4057qib7 8619 15 viral viral JJ cord-005453-4057qib7 8619 16 infections infection NNS cord-005453-4057qib7 8619 17 after after IN cord-005453-4057qib7 8619 18 HSCT HSCT NNP cord-005453-4057qib7 8619 19 the the DT cord-005453-4057qib7 8619 20 cause cause NN cord-005453-4057qib7 8619 21 of of IN cord-005453-4057qib7 8619 22 death death NN cord-005453-4057qib7 8619 23 could could MD cord-005453-4057qib7 8619 24 be be VB cord-005453-4057qib7 8619 25 multiorgan multiorgan NN cord-005453-4057qib7 8619 26 failure failure NN cord-005453-4057qib7 8619 27 due due JJ cord-005453-4057qib7 8619 28 to to IN cord-005453-4057qib7 8619 29 endothelium endothelium NN cord-005453-4057qib7 8619 30 cell cell NN cord-005453-4057qib7 8619 31 damage damage NN cord-005453-4057qib7 8619 32 syndrome syndrome NN cord-005453-4057qib7 8619 33 resulting result VBG cord-005453-4057qib7 8619 34 from from IN cord-005453-4057qib7 8619 35 persistent persistent JJ cord-005453-4057qib7 8619 36 inflammation inflammation NN cord-005453-4057qib7 8619 37 and and CC cord-005453-4057qib7 8619 38 drug drug NN cord-005453-4057qib7 8619 39 toxicity toxicity NN cord-005453-4057qib7 8619 40 effects effect NNS cord-005453-4057qib7 8619 41 . . . cord-005453-4057qib7 8620 1 Disclosure disclosure NN cord-005453-4057qib7 8620 2 Background background NN cord-005453-4057qib7 8620 3 : : : cord-005453-4057qib7 8620 4 Chronic chronic JJ cord-005453-4057qib7 8620 5 granulomatous granulomatous JJ cord-005453-4057qib7 8620 6 disease disease NN cord-005453-4057qib7 8620 7 ( ( -LRB- cord-005453-4057qib7 8620 8 CGD CGD NNP cord-005453-4057qib7 8620 9 ) ) -RRB- cord-005453-4057qib7 8620 10 is be VBZ cord-005453-4057qib7 8620 11 a a DT cord-005453-4057qib7 8620 12 primary primary JJ cord-005453-4057qib7 8620 13 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8620 14 ( ( -LRB- cord-005453-4057qib7 8620 15 PID PID NNP cord-005453-4057qib7 8620 16 ) ) -RRB- cord-005453-4057qib7 8620 17 caused cause VBN cord-005453-4057qib7 8620 18 by by IN cord-005453-4057qib7 8620 19 a a DT cord-005453-4057qib7 8620 20 mutation mutation NN cord-005453-4057qib7 8620 21 in in IN cord-005453-4057qib7 8620 22 1 1 CD cord-005453-4057qib7 8620 23 of of IN cord-005453-4057qib7 8620 24 the the DT cord-005453-4057qib7 8620 25 5 5 CD cord-005453-4057qib7 8620 26 subunits subunit NNS cord-005453-4057qib7 8620 27 of of IN cord-005453-4057qib7 8620 28 the the DT cord-005453-4057qib7 8620 29 nicotinamide nicotinamide NN cord-005453-4057qib7 8620 30 dinucleotide dinucleotide NN cord-005453-4057qib7 8620 31 phosphate phosphate NN cord-005453-4057qib7 8620 32 ( ( -LRB- cord-005453-4057qib7 8620 33 NADPH NADPH NNP cord-005453-4057qib7 8620 34 ) ) -RRB- cord-005453-4057qib7 8620 35 oxidase oxidase NN cord-005453-4057qib7 8620 36 , , , cord-005453-4057qib7 8620 37 which which WDT cord-005453-4057qib7 8620 38 leads lead VBZ cord-005453-4057qib7 8620 39 to to IN cord-005453-4057qib7 8620 40 a a DT cord-005453-4057qib7 8620 41 reduction reduction NN cord-005453-4057qib7 8620 42 in in IN cord-005453-4057qib7 8620 43 the the DT cord-005453-4057qib7 8620 44 microbicidal microbicidal JJ cord-005453-4057qib7 8620 45 activity activity NN cord-005453-4057qib7 8620 46 of of IN cord-005453-4057qib7 8620 47 phagocytic phagocytic JJ cord-005453-4057qib7 8620 48 cell cell NN cord-005453-4057qib7 8620 49 . . . cord-005453-4057qib7 8621 1 Starting start VBG cord-005453-4057qib7 8621 2 at at IN cord-005453-4057qib7 8621 3 an an DT cord-005453-4057qib7 8621 4 early early JJ cord-005453-4057qib7 8621 5 age age NN cord-005453-4057qib7 8621 6 , , , cord-005453-4057qib7 8621 7 CGD CGD NNP cord-005453-4057qib7 8621 8 patients patient NNS cord-005453-4057qib7 8621 9 suffer suffer VBP cord-005453-4057qib7 8621 10 from from IN cord-005453-4057qib7 8621 11 severe severe JJ cord-005453-4057qib7 8621 12 recurrent recurrent JJ cord-005453-4057qib7 8621 13 infections infection NNS cord-005453-4057qib7 8621 14 , , , cord-005453-4057qib7 8621 15 as as RB cord-005453-4057qib7 8621 16 well well RB cord-005453-4057qib7 8621 17 as as IN cord-005453-4057qib7 8621 18 inflammatory inflammatory JJ cord-005453-4057qib7 8621 19 events event NNS cord-005453-4057qib7 8621 20 . . . cord-005453-4057qib7 8622 1 Allogeneic allogeneic IN cord-005453-4057qib7 8622 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 8622 3 stem stem NN cord-005453-4057qib7 8622 4 cell cell NN cord-005453-4057qib7 8622 5 transplantation transplantation NN cord-005453-4057qib7 8622 6 ( ( -LRB- cord-005453-4057qib7 8622 7 HSCT HSCT NNP cord-005453-4057qib7 8622 8 ) ) -RRB- cord-005453-4057qib7 8622 9 is be VBZ cord-005453-4057qib7 8622 10 a a DT cord-005453-4057qib7 8622 11 curative curative JJ cord-005453-4057qib7 8622 12 option option NN cord-005453-4057qib7 8622 13 for for IN cord-005453-4057qib7 8622 14 CGD CGD NNP cord-005453-4057qib7 8622 15 in in IN cord-005453-4057qib7 8622 16 patients patient NNS cord-005453-4057qib7 8622 17 with with IN cord-005453-4057qib7 8622 18 insufficient insufficient JJ cord-005453-4057qib7 8622 19 benefit benefit NN cord-005453-4057qib7 8622 20 from from IN cord-005453-4057qib7 8622 21 supportive supportive JJ cord-005453-4057qib7 8622 22 care care NN cord-005453-4057qib7 8622 23 and and CC cord-005453-4057qib7 8622 24 prophylactic prophylactic JJ cord-005453-4057qib7 8622 25 antibiotics antibiotic NNS cord-005453-4057qib7 8622 26 . . . cord-005453-4057qib7 8623 1 We -PRON- PRP cord-005453-4057qib7 8623 2 reported report VBD cord-005453-4057qib7 8623 3 a a DT cord-005453-4057qib7 8623 4 series series NN cord-005453-4057qib7 8623 5 of of IN cord-005453-4057qib7 8623 6 39 39 CD cord-005453-4057qib7 8623 7 patients patient NNS cord-005453-4057qib7 8623 8 with with IN cord-005453-4057qib7 8623 9 CGD CGD NNP cord-005453-4057qib7 8623 10 who who WP cord-005453-4057qib7 8623 11 underwent undergo VBD cord-005453-4057qib7 8623 12 Unrelated unrelated JJ cord-005453-4057qib7 8623 13 umbilical umbilical JJ cord-005453-4057qib7 8623 14 cord cord NN cord-005453-4057qib7 8623 15 blood blood NN cord-005453-4057qib7 8623 16 transplantation transplantation NN cord-005453-4057qib7 8623 17 ( ( -LRB- cord-005453-4057qib7 8623 18 UCBT UCBT NNP cord-005453-4057qib7 8623 19 ) ) -RRB- cord-005453-4057qib7 8623 20 at at IN cord-005453-4057qib7 8623 21 our -PRON- PRP$ cord-005453-4057qib7 8623 22 center center NN cord-005453-4057qib7 8623 23 . . . cord-005453-4057qib7 8624 1 Methods method NNS cord-005453-4057qib7 8625 1 : : : cord-005453-4057qib7 8625 2 In in IN cord-005453-4057qib7 8625 3 this this DT cord-005453-4057qib7 8625 4 retrospective retrospective JJ cord-005453-4057qib7 8625 5 study study NN cord-005453-4057qib7 8625 6 , , , cord-005453-4057qib7 8625 7 we -PRON- PRP cord-005453-4057qib7 8625 8 observed observe VBD cord-005453-4057qib7 8625 9 a a DT cord-005453-4057qib7 8625 10 series series NN cord-005453-4057qib7 8625 11 of of IN cord-005453-4057qib7 8625 12 39 39 CD cord-005453-4057qib7 8625 13 consecutive consecutive JJ cord-005453-4057qib7 8625 14 UCBT UCBT NNS cord-005453-4057qib7 8625 15 performed perform VBN cord-005453-4057qib7 8625 16 at at IN cord-005453-4057qib7 8625 17 our -PRON- PRP$ cord-005453-4057qib7 8625 18 center center NN cord-005453-4057qib7 8625 19 in in IN cord-005453-4057qib7 8625 20 children child NNS cord-005453-4057qib7 8625 21 with with IN cord-005453-4057qib7 8625 22 CGD CGD NNP cord-005453-4057qib7 8625 23 between between IN cord-005453-4057qib7 8625 24 2015 2015 CD cord-005453-4057qib7 8625 25 and and CC cord-005453-4057qib7 8625 26 2018.Median 2018.median CD cord-005453-4057qib7 8625 27 age age NN cord-005453-4057qib7 8625 28 at at IN cord-005453-4057qib7 8625 29 transplantation transplantation NN cord-005453-4057qib7 8625 30 was be VBD cord-005453-4057qib7 8625 31 17 17 CD cord-005453-4057qib7 8625 32 months month NNS cord-005453-4057qib7 8625 33 ( ( -LRB- cord-005453-4057qib7 8625 34 range range NN cord-005453-4057qib7 8625 35 , , , cord-005453-4057qib7 8625 36 4 4 CD cord-005453-4057qib7 8625 37 to to TO cord-005453-4057qib7 8625 38 144 144 CD cord-005453-4057qib7 8625 39 months month NNS cord-005453-4057qib7 8625 40 ) ) -RRB- cord-005453-4057qib7 8625 41 , , , cord-005453-4057qib7 8625 42 Median median JJ cord-005453-4057qib7 8625 43 body body NN cord-005453-4057qib7 8625 44 weight weight NN cord-005453-4057qib7 8625 45 was be VBD cord-005453-4057qib7 8625 46 10 10 CD cord-005453-4057qib7 8625 47 kg kg NN cord-005453-4057qib7 8625 48 ( ( -LRB- cord-005453-4057qib7 8625 49 range range NN cord-005453-4057qib7 8625 50 , , , cord-005453-4057qib7 8625 51 6 6 CD cord-005453-4057qib7 8625 52 to to TO cord-005453-4057qib7 8625 53 34 34 CD cord-005453-4057qib7 8625 54 kg kg NNS cord-005453-4057qib7 8625 55 ) ) -RRB- cord-005453-4057qib7 8625 56 . . . cord-005453-4057qib7 8626 1 32/39 32/39 CD cord-005453-4057qib7 8626 2 patients patient NNS cord-005453-4057qib7 8626 3 received receive VBD cord-005453-4057qib7 8626 4 a a DT cord-005453-4057qib7 8626 5 myeloablative myeloablative JJ cord-005453-4057qib7 8626 6 conditioning conditioning NN cord-005453-4057qib7 8626 7 regimen regimen NN cord-005453-4057qib7 8626 8 consisting consist VBG cord-005453-4057qib7 8626 9 of of IN cord-005453-4057qib7 8626 10 busulfan busulfan NN cord-005453-4057qib7 8626 11 , , , cord-005453-4057qib7 8626 12 fludarabine fludarabine NN cord-005453-4057qib7 8626 13 , , , cord-005453-4057qib7 8626 14 cytarabine cytarabine NN cord-005453-4057qib7 8626 15 , , , cord-005453-4057qib7 8626 16 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 8626 17 and and CC cord-005453-4057qib7 8626 18 G G NNP cord-005453-4057qib7 8626 19 - - HYPH cord-005453-4057qib7 8626 20 CSF CSF NNP cord-005453-4057qib7 8626 21 , , , cord-005453-4057qib7 8626 22 7/39 7/39 CD cord-005453-4057qib7 8626 23 patients patient NNS cord-005453-4057qib7 8626 24 received receive VBD cord-005453-4057qib7 8626 25 another another DT cord-005453-4057qib7 8626 26 myeloablative myeloablative JJ cord-005453-4057qib7 8626 27 conditioning conditioning NN cord-005453-4057qib7 8626 28 regimen regimen NN cord-005453-4057qib7 8626 29 consisting consist VBG cord-005453-4057qib7 8626 30 of of IN cord-005453-4057qib7 8626 31 busulfan busulfan NN cord-005453-4057qib7 8626 32 , , , cord-005453-4057qib7 8626 33 fludarabine fludarabine NN cord-005453-4057qib7 8626 34 , , , cord-005453-4057qib7 8626 35 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 8626 36 and and CC cord-005453-4057qib7 8626 37 ATG ATG NNP cord-005453-4057qib7 8626 38 . . . cord-005453-4057qib7 8627 1 Prophylaxis prophylaxis NN cord-005453-4057qib7 8627 2 for for IN cord-005453-4057qib7 8627 3 graft graft NN cord-005453-4057qib7 8627 4 - - HYPH cord-005453-4057qib7 8627 5 versus versus IN cord-005453-4057qib7 8627 6 - - HYPH cord-005453-4057qib7 8627 7 host host NN cord-005453-4057qib7 8627 8 disease disease NN cord-005453-4057qib7 8627 9 ( ( -LRB- cord-005453-4057qib7 8627 10 GVHD GVHD NNP cord-005453-4057qib7 8627 11 ) ) -RRB- cord-005453-4057qib7 8627 12 was be VBD cord-005453-4057qib7 8627 13 tacrolimus tacrolimus JJ cord-005453-4057qib7 8627 14 . . . cord-005453-4057qib7 8628 1 Results result NNS cord-005453-4057qib7 8628 2 : : : cord-005453-4057qib7 8629 1 Engraftment Engraftment NNP cord-005453-4057qib7 8629 2 occurred occur VBD cord-005453-4057qib7 8629 3 in in IN cord-005453-4057qib7 8629 4 29/39 29/39 CD cord-005453-4057qib7 8629 5 ( ( -LRB- cord-005453-4057qib7 8629 6 74.4 74.4 CD cord-005453-4057qib7 8629 7 % % NN cord-005453-4057qib7 8629 8 ) ) -RRB- cord-005453-4057qib7 8629 9 patients patient NNS cord-005453-4057qib7 8629 10 . . . cord-005453-4057qib7 8630 1 10/39 10/39 CD cord-005453-4057qib7 8630 2 ( ( -LRB- cord-005453-4057qib7 8630 3 25.6 25.6 CD cord-005453-4057qib7 8630 4 % % NN cord-005453-4057qib7 8630 5 ) ) -RRB- cord-005453-4057qib7 8630 6 patients patient NNS cord-005453-4057qib7 8630 7 occurred occur VBD cord-005453-4057qib7 8630 8 graft graft NN cord-005453-4057qib7 8630 9 failure failure NN cord-005453-4057qib7 8630 10 , , , cord-005453-4057qib7 8630 11 all all DT cord-005453-4057qib7 8630 12 of of IN cord-005453-4057qib7 8630 13 them -PRON- PRP cord-005453-4057qib7 8630 14 received receive VBD cord-005453-4057qib7 8630 15 a a DT cord-005453-4057qib7 8630 16 myeloablative myeloablative JJ cord-005453-4057qib7 8630 17 conditioning conditioning NN cord-005453-4057qib7 8630 18 regimen regimen NN cord-005453-4057qib7 8630 19 without without IN cord-005453-4057qib7 8630 20 ATG ATG NNP cord-005453-4057qib7 8630 21 . . . cord-005453-4057qib7 8631 1 Median median JJ cord-005453-4057qib7 8631 2 time time NN cord-005453-4057qib7 8631 3 to to IN cord-005453-4057qib7 8631 4 neutrophil neutrophil NN cord-005453-4057qib7 8631 5 and and CC cord-005453-4057qib7 8631 6 platelet platelet NN cord-005453-4057qib7 8631 7 engraftment engraftment NN cord-005453-4057qib7 8631 8 were be VBD cord-005453-4057qib7 8631 9 24 24 CD cord-005453-4057qib7 8632 1 ( ( -LRB- cord-005453-4057qib7 8632 2 rang rang NNP cord-005453-4057qib7 8632 3 , , , cord-005453-4057qib7 8632 4 14 14 CD cord-005453-4057qib7 8632 5 - - SYM cord-005453-4057qib7 8632 6 46 46 CD cord-005453-4057qib7 8632 7 ) ) -RRB- cord-005453-4057qib7 8632 8 and and CC cord-005453-4057qib7 8632 9 36.5 36.5 CD cord-005453-4057qib7 8632 10 ( ( -LRB- cord-005453-4057qib7 8632 11 rang rang NNP cord-005453-4057qib7 8632 12 , , , cord-005453-4057qib7 8632 13 15 15 CD cord-005453-4057qib7 8632 14 - - SYM cord-005453-4057qib7 8632 15 51 51 CD cord-005453-4057qib7 8632 16 ) ) -RRB- cord-005453-4057qib7 8632 17 days day NNS cord-005453-4057qib7 8632 18 . . . cord-005453-4057qib7 8633 1 22/39 22/39 CD cord-005453-4057qib7 8633 2 ( ( -LRB- cord-005453-4057qib7 8633 3 56.4 56.4 CD cord-005453-4057qib7 8633 4 % % NN cord-005453-4057qib7 8633 5 ) ) -RRB- cord-005453-4057qib7 8633 6 patients patient NNS cord-005453-4057qib7 8633 7 developed develop VBD cord-005453-4057qib7 8633 8 acute acute JJ cord-005453-4057qib7 8633 9 GVHD GVHD NNP cord-005453-4057qib7 8633 10 , , , cord-005453-4057qib7 8633 11 with with IN cord-005453-4057qib7 8633 12 4/39 4/39 CD cord-005453-4057qib7 8633 13 ( ( -LRB- cord-005453-4057qib7 8633 14 10.3 10.3 CD cord-005453-4057qib7 8633 15 % % NN cord-005453-4057qib7 8633 16 ) ) -RRB- cord-005453-4057qib7 8633 17 episodes episode NNS cord-005453-4057qib7 8633 18 of of IN cord-005453-4057qib7 8633 19 grade grade NN cord-005453-4057qib7 8633 20 III III NNP cord-005453-4057qib7 8633 21 - - HYPH cord-005453-4057qib7 8633 22 IV IV NNP cord-005453-4057qib7 8633 23 aGVHD aGVHD NNP cord-005453-4057qib7 8633 24 . . . cord-005453-4057qib7 8634 1 Chronic chronic JJ cord-005453-4057qib7 8634 2 GVHD GVHD NNP cord-005453-4057qib7 8634 3 occurred occur VBD cord-005453-4057qib7 8634 4 in in IN cord-005453-4057qib7 8634 5 3/29 3/29 CD cord-005453-4057qib7 8634 6 patients patient NNS cord-005453-4057qib7 8634 7 ( ( -LRB- cord-005453-4057qib7 8634 8 10.3 10.3 CD cord-005453-4057qib7 8634 9 % % NN cord-005453-4057qib7 8634 10 ) ) -RRB- cord-005453-4057qib7 8634 11 . . . cord-005453-4057qib7 8635 1 At at IN cord-005453-4057qib7 8635 2 a a DT cord-005453-4057qib7 8635 3 median median JJ cord-005453-4057qib7 8635 4 follow follow NN cord-005453-4057qib7 8635 5 - - HYPH cord-005453-4057qib7 8635 6 up up NN cord-005453-4057qib7 8635 7 of of IN cord-005453-4057qib7 8635 8 17 17 CD cord-005453-4057qib7 8635 9 months month NNS cord-005453-4057qib7 8635 10 ( ( -LRB- cord-005453-4057qib7 8635 11 rang rang NN cord-005453-4057qib7 8635 12 , , , cord-005453-4057qib7 8635 13 1 1 CD cord-005453-4057qib7 8635 14 to to TO cord-005453-4057qib7 8635 15 44 44 CD cord-005453-4057qib7 8635 16 months month NNS cord-005453-4057qib7 8635 17 ) ) -RRB- cord-005453-4057qib7 8635 18 , , , cord-005453-4057qib7 8635 19 the the DT cord-005453-4057qib7 8635 20 overall overall JJ cord-005453-4057qib7 8635 21 survival survival NN cord-005453-4057qib7 8635 22 rate rate NN cord-005453-4057qib7 8635 23 was be VBD cord-005453-4057qib7 8635 24 83.7 83.7 CD cord-005453-4057qib7 8635 25 % % NN cord-005453-4057qib7 8635 26 , , , cord-005453-4057qib7 8635 27 and and CC cord-005453-4057qib7 8635 28 event event NN cord-005453-4057qib7 8635 29 - - HYPH cord-005453-4057qib7 8635 30 free free JJ cord-005453-4057qib7 8635 31 survival survival NN cord-005453-4057qib7 8635 32 rate rate NN cord-005453-4057qib7 8635 33 was be VBD cord-005453-4057qib7 8635 34 66.7 66.7 CD cord-005453-4057qib7 8635 35 % % NN cord-005453-4057qib7 8635 36 . . . cord-005453-4057qib7 8636 1 Conclusions conclusion NNS cord-005453-4057qib7 8636 2 : : : cord-005453-4057qib7 8637 1 Unrelated unrelated JJ cord-005453-4057qib7 8637 2 UCBT UCBT NNS cord-005453-4057qib7 8637 3 should should MD cord-005453-4057qib7 8637 4 be be VB cord-005453-4057qib7 8637 5 considered consider VBN cord-005453-4057qib7 8637 6 as as IN cord-005453-4057qib7 8637 7 potential potential JJ cord-005453-4057qib7 8637 8 curative curative JJ cord-005453-4057qib7 8637 9 methods method NNS cord-005453-4057qib7 8637 10 in in IN cord-005453-4057qib7 8637 11 children child NNS cord-005453-4057qib7 8637 12 with with IN cord-005453-4057qib7 8637 13 CGD CGD NNP cord-005453-4057qib7 8637 14 . . . cord-005453-4057qib7 8638 1 CGD CGD NNP cord-005453-4057qib7 8638 2 patients patient NNS cord-005453-4057qib7 8638 3 who who WP cord-005453-4057qib7 8638 4 used use VBD cord-005453-4057qib7 8638 5 myeloablative myeloablative NNP cord-005453-4057qib7 8638 6 conditioning conditioning NN cord-005453-4057qib7 8638 7 regimen regimen NN cord-005453-4057qib7 8638 8 with with IN cord-005453-4057qib7 8638 9 ATG ATG NNP cord-005453-4057qib7 8638 10 shows show VBZ cord-005453-4057qib7 8638 11 better well JJR cord-005453-4057qib7 8638 12 graft graft NN cord-005453-4057qib7 8638 13 and and CC cord-005453-4057qib7 8638 14 survival survival NN cord-005453-4057qib7 8638 15 . . . cord-005453-4057qib7 8639 1 Disclosure disclosure NN cord-005453-4057qib7 8639 2 : : : cord-005453-4057qib7 8639 3 Nothing nothing NN cord-005453-4057qib7 8639 4 to to TO cord-005453-4057qib7 8639 5 declare declare VB cord-005453-4057qib7 8639 6 Background background NN cord-005453-4057qib7 8639 7 : : : cord-005453-4057qib7 8639 8 Invasive invasive JJ cord-005453-4057qib7 8639 9 fungal fungal JJ cord-005453-4057qib7 8639 10 infections infection NNS cord-005453-4057qib7 8639 11 ( ( -LRB- cord-005453-4057qib7 8639 12 IFI IFI NNP cord-005453-4057qib7 8639 13 ) ) -RRB- cord-005453-4057qib7 8639 14 remain remain VBP cord-005453-4057qib7 8639 15 a a DT cord-005453-4057qib7 8639 16 major major JJ cord-005453-4057qib7 8639 17 cause cause NN cord-005453-4057qib7 8639 18 of of IN cord-005453-4057qib7 8639 19 treatment treatment NN cord-005453-4057qib7 8639 20 - - HYPH cord-005453-4057qib7 8639 21 related relate VBN cord-005453-4057qib7 8639 22 morbidity morbidity NN cord-005453-4057qib7 8639 23 and and CC cord-005453-4057qib7 8639 24 mortality mortality NN cord-005453-4057qib7 8639 25 in in IN cord-005453-4057qib7 8639 26 AML AML NNP cord-005453-4057qib7 8639 27 patients patient NNS cord-005453-4057qib7 8639 28 . . . cord-005453-4057qib7 8640 1 Although although IN cord-005453-4057qib7 8640 2 not not RB cord-005453-4057qib7 8640 3 uncommon uncommon JJ cord-005453-4057qib7 8640 4 , , , cord-005453-4057qib7 8640 5 the the DT cord-005453-4057qib7 8640 6 presentation presentation NN cord-005453-4057qib7 8640 7 of of IN cord-005453-4057qib7 8640 8 unusually unusually RB cord-005453-4057qib7 8640 9 severe severe JJ cord-005453-4057qib7 8640 10 clinical clinical JJ cord-005453-4057qib7 8640 11 features feature NNS cord-005453-4057qib7 8640 12 might may MD cord-005453-4057qib7 8640 13 be be VB cord-005453-4057qib7 8640 14 indicative indicative JJ cord-005453-4057qib7 8640 15 for for IN cord-005453-4057qib7 8640 16 an an DT cord-005453-4057qib7 8640 17 underlying underlie VBG cord-005453-4057qib7 8640 18 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8640 19 . . . cord-005453-4057qib7 8641 1 Caspase Caspase NNP cord-005453-4057qib7 8641 2 - - HYPH cord-005453-4057qib7 8641 3 associated associate VBN cord-005453-4057qib7 8641 4 recruitment recruitment NN cord-005453-4057qib7 8641 5 domain domain NN cord-005453-4057qib7 8641 6 9 9 CD cord-005453-4057qib7 8641 7 ( ( -LRB- cord-005453-4057qib7 8641 8 CARD9 CARD9 NNP cord-005453-4057qib7 8641 9 ) ) -RRB- cord-005453-4057qib7 8641 10 is be VBZ cord-005453-4057qib7 8641 11 recognized recognize VBN cord-005453-4057qib7 8641 12 to to TO cord-005453-4057qib7 8641 13 have have VB cord-005453-4057qib7 8641 14 a a DT cord-005453-4057qib7 8641 15 crucial crucial JJ cord-005453-4057qib7 8641 16 role role NN cord-005453-4057qib7 8641 17 in in IN cord-005453-4057qib7 8641 18 effective effective JJ cord-005453-4057qib7 8641 19 antifungal antifungal JJ cord-005453-4057qib7 8641 20 response response NN cord-005453-4057qib7 8641 21 , , , cord-005453-4057qib7 8641 22 leading lead VBG cord-005453-4057qib7 8641 23 to to IN cord-005453-4057qib7 8641 24 Th1 th1 CD cord-005453-4057qib7 8641 25 and and CC cord-005453-4057qib7 8641 26 Th17 th17 CD cord-005453-4057qib7 8641 27 differentiation differentiation NN cord-005453-4057qib7 8641 28 and and CC cord-005453-4057qib7 8641 29 to to IN cord-005453-4057qib7 8641 30 the the DT cord-005453-4057qib7 8641 31 initiation initiation NN cord-005453-4057qib7 8641 32 of of IN cord-005453-4057qib7 8641 33 the the DT cord-005453-4057qib7 8641 34 inflammatory inflammatory JJ cord-005453-4057qib7 8641 35 cytokine cytokine NN cord-005453-4057qib7 8641 36 cascade cascade NN cord-005453-4057qib7 8641 37 . . . cord-005453-4057qib7 8642 1 Particularly particularly RB cord-005453-4057qib7 8642 2 interferon interferon NN cord-005453-4057qib7 8642 3 - - HYPH cord-005453-4057qib7 8642 4 gamma gamma NN cord-005453-4057qib7 8642 5 ( ( -LRB- cord-005453-4057qib7 8642 6 IFNg IFNg NNP cord-005453-4057qib7 8642 7 ) ) -RRB- cord-005453-4057qib7 8642 8 increases increase VBZ cord-005453-4057qib7 8642 9 macrophage macrophage NN cord-005453-4057qib7 8642 10 activity activity NN cord-005453-4057qib7 8642 11 . . . cord-005453-4057qib7 8643 1 Patients patient NNS cord-005453-4057qib7 8643 2 with with IN cord-005453-4057qib7 8643 3 homozygous homozygous JJ cord-005453-4057qib7 8643 4 CARD9 CARD9 NNS cord-005453-4057qib7 8643 5 mutations mutation NNS cord-005453-4057qib7 8643 6 are be VBP cord-005453-4057qib7 8643 7 known know VBN cord-005453-4057qib7 8643 8 to to TO cord-005453-4057qib7 8643 9 have have VB cord-005453-4057qib7 8643 10 a a DT cord-005453-4057qib7 8643 11 significantly significantly RB cord-005453-4057qib7 8643 12 increased increase VBN cord-005453-4057qib7 8643 13 susceptibility susceptibility NN cord-005453-4057qib7 8643 14 to to IN cord-005453-4057qib7 8643 15 life life NN cord-005453-4057qib7 8643 16 - - HYPH cord-005453-4057qib7 8643 17 threatening threaten VBG cord-005453-4057qib7 8643 18 systemic systemic JJ cord-005453-4057qib7 8643 19 candidiasis candidiasi NNS cord-005453-4057qib7 8643 20 . . . cord-005453-4057qib7 8644 1 However however RB cord-005453-4057qib7 8644 2 , , , cord-005453-4057qib7 8644 3 some some DT cord-005453-4057qib7 8644 4 sequence sequence NN cord-005453-4057qib7 8644 5 variants variant NNS cord-005453-4057qib7 8644 6 may may MD cord-005453-4057qib7 8644 7 lead lead VB cord-005453-4057qib7 8644 8 to to IN cord-005453-4057qib7 8644 9 increased increase VBN cord-005453-4057qib7 8644 10 IFI IFI NNP cord-005453-4057qib7 8644 11 - - HYPH cord-005453-4057qib7 8644 12 susceptibility susceptibility NN cord-005453-4057qib7 8644 13 even even RB cord-005453-4057qib7 8644 14 in in IN cord-005453-4057qib7 8644 15 heterozygosity heterozygosity NN cord-005453-4057qib7 8644 16 , , , cord-005453-4057qib7 8644 17 e.g. e.g. RB cord-005453-4057qib7 8644 18 under under IN cord-005453-4057qib7 8644 19 immunosuppression immunosuppression NN cord-005453-4057qib7 8644 20 . . . cord-005453-4057qib7 8645 1 IFN IFN NNP cord-005453-4057qib7 8645 2 - - HYPH cord-005453-4057qib7 8645 3 γ γ NNP cord-005453-4057qib7 8645 4 has have VBZ cord-005453-4057qib7 8645 5 been be VBN cord-005453-4057qib7 8645 6 described describe VBN cord-005453-4057qib7 8645 7 as as IN cord-005453-4057qib7 8645 8 an an DT cord-005453-4057qib7 8645 9 additive additive NN cord-005453-4057qib7 8645 10 treatment treatment NN cord-005453-4057qib7 8645 11 option option NN cord-005453-4057qib7 8645 12 because because IN cord-005453-4057qib7 8645 13 of of IN cord-005453-4057qib7 8645 14 its -PRON- PRP$ cord-005453-4057qib7 8645 15 immune immune JJ cord-005453-4057qib7 8645 16 stimulating stimulating JJ cord-005453-4057qib7 8645 17 effect effect NN cord-005453-4057qib7 8645 18 on on IN cord-005453-4057qib7 8645 19 the the DT cord-005453-4057qib7 8645 20 leukocyte leukocyte NN cord-005453-4057qib7 8645 21 immune immune JJ cord-005453-4057qib7 8645 22 response response NN cord-005453-4057qib7 8645 23 in in IN cord-005453-4057qib7 8645 24 a a DT cord-005453-4057qib7 8645 25 situation situation NN cord-005453-4057qib7 8645 26 of of IN cord-005453-4057qib7 8645 27 immunological immunological JJ cord-005453-4057qib7 8645 28 " " `` cord-005453-4057qib7 8645 29 blindness blindness NN cord-005453-4057qib7 8645 30 " " '' cord-005453-4057qib7 8645 31 . . . cord-005453-4057qib7 8646 1 Methods method NNS cord-005453-4057qib7 8646 2 : : : cord-005453-4057qib7 8646 3 Here here RB cord-005453-4057qib7 8646 4 , , , cord-005453-4057qib7 8646 5 we -PRON- PRP cord-005453-4057qib7 8646 6 report report VBP cord-005453-4057qib7 8646 7 the the DT cord-005453-4057qib7 8646 8 case case NN cord-005453-4057qib7 8646 9 of of IN cord-005453-4057qib7 8646 10 an an DT cord-005453-4057qib7 8646 11 11-year 11-year JJ cord-005453-4057qib7 8646 12 old old JJ cord-005453-4057qib7 8646 13 male male NN cord-005453-4057qib7 8646 14 with with IN cord-005453-4057qib7 8646 15 AML AML NNP cord-005453-4057qib7 8646 16 M6 M6 NNP cord-005453-4057qib7 8646 17 with with IN cord-005453-4057qib7 8646 18 a a DT cord-005453-4057qib7 8646 19 severe severe JJ cord-005453-4057qib7 8646 20 systemic systemic JJ cord-005453-4057qib7 8646 21 candida candida NN cord-005453-4057qib7 8646 22 tropicalis tropicalis NNP cord-005453-4057qib7 8646 23 infection infection NN cord-005453-4057qib7 8646 24 , , , cord-005453-4057qib7 8646 25 unresponsive unresponsive JJ cord-005453-4057qib7 8646 26 to to IN cord-005453-4057qib7 8646 27 triple triple JJ cord-005453-4057qib7 8646 28 - - HYPH cord-005453-4057qib7 8646 29 antimycotic antimycotic JJ cord-005453-4057qib7 8646 30 regimen regimen NN cord-005453-4057qib7 8646 31 , , , cord-005453-4057qib7 8646 32 leading lead VBG cord-005453-4057qib7 8646 33 to to IN cord-005453-4057qib7 8646 34 multi multi JJ cord-005453-4057qib7 8646 35 - - JJ cord-005453-4057qib7 8646 36 organ organ JJ cord-005453-4057qib7 8646 37 failure failure NN cord-005453-4057qib7 8646 38 . . . cord-005453-4057qib7 8647 1 He -PRON- PRP cord-005453-4057qib7 8647 2 was be VBD cord-005453-4057qib7 8647 3 discovered discover VBN cord-005453-4057qib7 8647 4 to to TO cord-005453-4057qib7 8647 5 bear bear VB cord-005453-4057qib7 8647 6 a a DT cord-005453-4057qib7 8647 7 heterozygous heterozygous JJ cord-005453-4057qib7 8647 8 CARD9 CARD9 NNP cord-005453-4057qib7 8647 9 mutation mutation NN cord-005453-4057qib7 8647 10 , , , cord-005453-4057qib7 8647 11 and and CC cord-005453-4057qib7 8647 12 IFN IFN NNP cord-005453-4057qib7 8647 13 - - HYPH cord-005453-4057qib7 8647 14 γ γ NNP cord-005453-4057qib7 8647 15 immunotherapy immunotherapy NN cord-005453-4057qib7 8647 16 leaded lead VBN cord-005453-4057qib7 8647 17 to to TO cord-005453-4057qib7 8647 18 complete complete VB cord-005453-4057qib7 8647 19 response response NN cord-005453-4057qib7 8647 20 of of IN cord-005453-4057qib7 8647 21 all all DT cord-005453-4057qib7 8647 22 disseminated disseminate VBN cord-005453-4057qib7 8647 23 infections infection NNS cord-005453-4057qib7 8647 24 . . . cord-005453-4057qib7 8648 1 Results result NNS cord-005453-4057qib7 8648 2 : : : cord-005453-4057qib7 8649 1 The the DT cord-005453-4057qib7 8649 2 patient patient NN cord-005453-4057qib7 8649 3 developed develop VBD cord-005453-4057qib7 8649 4 septic septic JJ cord-005453-4057qib7 8649 5 fever fever NN cord-005453-4057qib7 8649 6 immediately immediately RB cord-005453-4057qib7 8649 7 after after IN cord-005453-4057qib7 8649 8 the the DT cord-005453-4057qib7 8649 9 first first JJ cord-005453-4057qib7 8649 10 chemotherapy chemotherapy NN cord-005453-4057qib7 8649 11 cycle cycle NN cord-005453-4057qib7 8649 12 . . . cord-005453-4057qib7 8650 1 Unexpectedly unexpectedly RB cord-005453-4057qib7 8650 2 , , , cord-005453-4057qib7 8650 3 candida candida NNP cord-005453-4057qib7 8650 4 tropicalis tropicalis NNP cord-005453-4057qib7 8650 5 was be VBD cord-005453-4057qib7 8650 6 confirmed confirm VBN cord-005453-4057qib7 8650 7 in in IN cord-005453-4057qib7 8650 8 the the DT cord-005453-4057qib7 8650 9 blood blood NN cord-005453-4057qib7 8650 10 culture culture NN cord-005453-4057qib7 8650 11 within within IN cord-005453-4057qib7 8650 12 24 24 CD cord-005453-4057qib7 8650 13 hours hour NNS cord-005453-4057qib7 8650 14 . . . cord-005453-4057qib7 8651 1 Liposomal Liposomal NNP cord-005453-4057qib7 8651 2 amphotericin amphotericin NNS cord-005453-4057qib7 8651 3 B b NN cord-005453-4057qib7 8651 4 ( ( -LRB- cord-005453-4057qib7 8651 5 Ambisome Ambisome NNP cord-005453-4057qib7 8651 6 ® ® NNP cord-005453-4057qib7 8651 7 ) ) -RRB- cord-005453-4057qib7 8651 8 was be VBD cord-005453-4057qib7 8651 9 started start VBN cord-005453-4057qib7 8651 10 immediately immediately RB cord-005453-4057qib7 8651 11 , , , cord-005453-4057qib7 8651 12 however however RB cord-005453-4057qib7 8651 13 candida candida NNP cord-005453-4057qib7 8651 14 rapidly rapidly RB cord-005453-4057qib7 8651 15 disseminated disseminate VBN cord-005453-4057qib7 8651 16 to to IN cord-005453-4057qib7 8651 17 lungs lung NNS cord-005453-4057qib7 8651 18 , , , cord-005453-4057qib7 8651 19 liver liver NN cord-005453-4057qib7 8651 20 , , , cord-005453-4057qib7 8651 21 spleen spleen NNS cord-005453-4057qib7 8651 22 , , , cord-005453-4057qib7 8651 23 kidneys kidney NNS cord-005453-4057qib7 8651 24 and and CC cord-005453-4057qib7 8651 25 CNS CNS NNP cord-005453-4057qib7 8651 26 despite despite IN cord-005453-4057qib7 8651 27 extended extend VBN cord-005453-4057qib7 8651 28 antimycotic antimycotic JJ cord-005453-4057qib7 8651 29 therapy therapy NN cord-005453-4057qib7 8651 30 with with IN cord-005453-4057qib7 8651 31 caspofungin caspofungin NNP cord-005453-4057qib7 8651 32 , , , cord-005453-4057qib7 8651 33 voriconazole voriconazole NNP cord-005453-4057qib7 8651 34 and and CC cord-005453-4057qib7 8651 35 fluconazole fluconazole NN cord-005453-4057qib7 8651 36 . . . cord-005453-4057qib7 8652 1 The the DT cord-005453-4057qib7 8652 2 patient patient NN cord-005453-4057qib7 8652 3 was be VBD cord-005453-4057qib7 8652 4 splenectomized splenectomize VBN cord-005453-4057qib7 8652 5 due due IN cord-005453-4057qib7 8652 6 to to IN cord-005453-4057qib7 8652 7 massive massive JJ cord-005453-4057qib7 8652 8 infiltration infiltration NN cord-005453-4057qib7 8652 9 ( ( -LRB- cord-005453-4057qib7 8652 10 Figure figure NN cord-005453-4057qib7 8652 11 1 1 CD cord-005453-4057qib7 8652 12 ) ) -RRB- cord-005453-4057qib7 8652 13 . . . cord-005453-4057qib7 8653 1 Genetic genetic JJ cord-005453-4057qib7 8653 2 testing testing NN cord-005453-4057qib7 8653 3 for for IN cord-005453-4057qib7 8653 4 mycosis mycosis NNP cord-005453-4057qib7 8653 5 predisposition predisposition NN cord-005453-4057qib7 8653 6 revealed reveal VBD cord-005453-4057qib7 8653 7 a a DT cord-005453-4057qib7 8653 8 heterozygous heterozygous JJ cord-005453-4057qib7 8653 9 mutation mutation NN cord-005453-4057qib7 8653 10 in in IN cord-005453-4057qib7 8653 11 the the DT cord-005453-4057qib7 8653 12 CARD9 CARD9 NNP cord-005453-4057qib7 8653 13 gene gene NN cord-005453-4057qib7 8653 14 , , , cord-005453-4057qib7 8653 15 inherited inherit VBN cord-005453-4057qib7 8653 16 from from IN cord-005453-4057qib7 8653 17 the the DT cord-005453-4057qib7 8653 18 father father NN cord-005453-4057qib7 8653 19 ( ( -LRB- cord-005453-4057qib7 8653 20 c.809a c.809a XX cord-005453-4057qib7 8654 1 > > XX cord-005453-4057qib7 8655 1 T(p t(p UH cord-005453-4057qib7 8655 2 . . . cord-005453-4057qib7 8655 3 Glu270Val Glu270Val NNP cord-005453-4057qib7 8655 4 ) ) -RRB- cord-005453-4057qib7 8655 5 ) ) -RRB- cord-005453-4057qib7 8655 6 . . . cord-005453-4057qib7 8656 1 IFN IFN NNP cord-005453-4057qib7 8656 2 - - HYPH cord-005453-4057qib7 8656 3 γ γ NN cord-005453-4057qib7 8656 4 treatment treatment NN cord-005453-4057qib7 8656 5 was be VBD cord-005453-4057qib7 8656 6 started start VBN cord-005453-4057qib7 8656 7 ( ( -LRB- cord-005453-4057qib7 8656 8 100 100 CD cord-005453-4057qib7 8656 9 μg μg NNP cord-005453-4057qib7 8656 10 subcutaneously subcutaneously RB cord-005453-4057qib7 8656 11 , , , cord-005453-4057qib7 8656 12 3 3 CD cord-005453-4057qib7 8656 13 times time NNS cord-005453-4057qib7 8656 14 per per IN cord-005453-4057qib7 8656 15 week week NN cord-005453-4057qib7 8656 16 ) ) -RRB- cord-005453-4057qib7 8656 17 , , , cord-005453-4057qib7 8656 18 leading lead VBG cord-005453-4057qib7 8656 19 to to IN cord-005453-4057qib7 8656 20 an an DT cord-005453-4057qib7 8656 21 almost almost RB cord-005453-4057qib7 8656 22 complete complete JJ cord-005453-4057qib7 8656 23 response response NN cord-005453-4057qib7 8656 24 of of IN cord-005453-4057qib7 8656 25 disseminated disseminate VBN cord-005453-4057qib7 8656 26 infections infection NNS cord-005453-4057qib7 8656 27 . . . cord-005453-4057qib7 8657 1 Due due IN cord-005453-4057qib7 8657 2 to to IN cord-005453-4057qib7 8657 3 the the DT cord-005453-4057qib7 8657 4 severe severe JJ cord-005453-4057qib7 8657 5 infection infection NN cord-005453-4057qib7 8657 6 , , , cord-005453-4057qib7 8657 7 chemotherapy chemotherapy NN cord-005453-4057qib7 8657 8 had have VBD cord-005453-4057qib7 8657 9 to to TO cord-005453-4057qib7 8657 10 be be VB cord-005453-4057qib7 8657 11 interrupted interrupt VBN cord-005453-4057qib7 8657 12 after after IN cord-005453-4057qib7 8657 13 one one CD cord-005453-4057qib7 8657 14 course course NN cord-005453-4057qib7 8657 15 . . . cord-005453-4057qib7 8658 1 However however RB cord-005453-4057qib7 8658 2 , , , cord-005453-4057qib7 8658 3 bone bone NN cord-005453-4057qib7 8658 4 marrow marrow NN cord-005453-4057qib7 8658 5 remained remain VBD cord-005453-4057qib7 8658 6 in in IN cord-005453-4057qib7 8658 7 complete complete JJ cord-005453-4057qib7 8658 8 remission remission NN cord-005453-4057qib7 8658 9 for for IN cord-005453-4057qib7 8658 10 almost almost RB cord-005453-4057qib7 8658 11 one one CD cord-005453-4057qib7 8658 12 year year NN cord-005453-4057qib7 8658 13 . . . cord-005453-4057qib7 8659 1 The the DT cord-005453-4057qib7 8659 2 patient patient NN cord-005453-4057qib7 8659 3 experienced experience VBD cord-005453-4057qib7 8659 4 altogether altogether RB cord-005453-4057qib7 8659 5 two two CD cord-005453-4057qib7 8659 6 relapses relapse NNS cord-005453-4057qib7 8659 7 requiring require VBG cord-005453-4057qib7 8659 8 an an DT cord-005453-4057qib7 8659 9 unrelated unrelated JJ cord-005453-4057qib7 8659 10 allogeneic allogeneic NN cord-005453-4057qib7 8659 11 and and CC cord-005453-4057qib7 8659 12 a a DT cord-005453-4057qib7 8659 13 haploidentical haploidentical JJ cord-005453-4057qib7 8659 14 HSCT HSCT NNP cord-005453-4057qib7 8659 15 . . . cord-005453-4057qib7 8660 1 Under under IN cord-005453-4057qib7 8660 2 combined combine VBN cord-005453-4057qib7 8660 3 IFN IFN NNP cord-005453-4057qib7 8660 4 - - HYPH cord-005453-4057qib7 8660 5 γ γ NNP cord-005453-4057qib7 8660 6 and and CC cord-005453-4057qib7 8660 7 ambisome/ ambisome/ NNP cord-005453-4057qib7 8660 8 fluconazole fluconazole NN cord-005453-4057qib7 8660 9 prophylaxis prophylaxis NN cord-005453-4057qib7 8661 1 no no DT cord-005453-4057qib7 8661 2 further further JJ cord-005453-4057qib7 8661 3 mycosis mycosis NNP cord-005453-4057qib7 8661 4 was be VBD cord-005453-4057qib7 8661 5 observed observe VBN cord-005453-4057qib7 8661 6 despite despite IN cord-005453-4057qib7 8661 7 extensive extensive JJ cord-005453-4057qib7 8661 8 and and CC cord-005453-4057qib7 8661 9 prolonged prolonged JJ cord-005453-4057qib7 8661 10 immunosuppression immunosuppression NN cord-005453-4057qib7 8661 11 . . . cord-005453-4057qib7 8662 1 Conclusions conclusion NNS cord-005453-4057qib7 8662 2 : : : cord-005453-4057qib7 8663 1 IFI IFI NNP cord-005453-4057qib7 8663 2 in in IN cord-005453-4057qib7 8663 3 AML AML NNP cord-005453-4057qib7 8663 4 patients patient NNS cord-005453-4057qib7 8663 5 are be VBP cord-005453-4057qib7 8663 6 common common JJ cord-005453-4057qib7 8663 7 , , , cord-005453-4057qib7 8663 8 however however RB cord-005453-4057qib7 8663 9 an an DT cord-005453-4057qib7 8663 10 unusual unusual JJ cord-005453-4057qib7 8663 11 presentation presentation NN cord-005453-4057qib7 8663 12 in in IN cord-005453-4057qib7 8663 13 presumably presumably RB cord-005453-4057qib7 8663 14 immune immune JJ cord-005453-4057qib7 8663 15 competent competent JJ cord-005453-4057qib7 8663 16 individuals individual NNS cord-005453-4057qib7 8663 17 should should MD cord-005453-4057qib7 8663 18 raise raise VB cord-005453-4057qib7 8663 19 the the DT cord-005453-4057qib7 8663 20 suspicion suspicion NN cord-005453-4057qib7 8663 21 for for IN cord-005453-4057qib7 8663 22 immunodeficiencies immunodeficiency NNS cord-005453-4057qib7 8663 23 . . . cord-005453-4057qib7 8664 1 In in IN cord-005453-4057qib7 8664 2 our -PRON- PRP$ cord-005453-4057qib7 8664 3 case case NN cord-005453-4057qib7 8664 4 , , , cord-005453-4057qib7 8664 5 an an DT cord-005453-4057qib7 8664 6 unexpected unexpected JJ cord-005453-4057qib7 8664 7 early early JJ cord-005453-4057qib7 8664 8 candida candida NN cord-005453-4057qib7 8664 9 - - HYPH cord-005453-4057qib7 8664 10 sepsis sepsis NN cord-005453-4057qib7 8664 11 was be VBD cord-005453-4057qib7 8664 12 completely completely RB cord-005453-4057qib7 8664 13 unresponsive unresponsive JJ cord-005453-4057qib7 8664 14 to to IN cord-005453-4057qib7 8664 15 an an DT cord-005453-4057qib7 8664 16 adequate adequate JJ cord-005453-4057qib7 8664 17 multi multi JJ cord-005453-4057qib7 8664 18 - - JJ cord-005453-4057qib7 8664 19 agent agent JJ cord-005453-4057qib7 8664 20 treatment treatment NN cord-005453-4057qib7 8664 21 . . . cord-005453-4057qib7 8665 1 While while IN cord-005453-4057qib7 8665 2 IFN IFN NNP cord-005453-4057qib7 8665 3 - - HYPH cord-005453-4057qib7 8665 4 γ γ NNP cord-005453-4057qib7 8665 5 is be VBZ cord-005453-4057qib7 8665 6 used use VBN cord-005453-4057qib7 8665 7 in in IN cord-005453-4057qib7 8665 8 adults adult NNS cord-005453-4057qib7 8665 9 as as IN cord-005453-4057qib7 8665 10 an an DT cord-005453-4057qib7 8665 11 immune immune JJ cord-005453-4057qib7 8665 12 stimulatory stimulatory JJ cord-005453-4057qib7 8665 13 cytokine cytokine NN cord-005453-4057qib7 8665 14 , , , cord-005453-4057qib7 8665 15 little little JJ cord-005453-4057qib7 8665 16 data datum NNS cord-005453-4057qib7 8665 17 are be VBP cord-005453-4057qib7 8665 18 available available JJ cord-005453-4057qib7 8665 19 for for IN cord-005453-4057qib7 8665 20 children child NNS cord-005453-4057qib7 8665 21 . . . cord-005453-4057qib7 8666 1 To to IN cord-005453-4057qib7 8666 2 our -PRON- PRP$ cord-005453-4057qib7 8666 3 knowledge knowledge NN cord-005453-4057qib7 8666 4 , , , cord-005453-4057qib7 8666 5 this this DT cord-005453-4057qib7 8666 6 is be VBZ cord-005453-4057qib7 8666 7 the the DT cord-005453-4057qib7 8666 8 first first JJ cord-005453-4057qib7 8666 9 case case NN cord-005453-4057qib7 8666 10 of of IN cord-005453-4057qib7 8666 11 successful successful JJ cord-005453-4057qib7 8666 12 IFN IFN NNP cord-005453-4057qib7 8666 13 - - HYPH cord-005453-4057qib7 8666 14 γ γ NN cord-005453-4057qib7 8666 15 treatment treatment NN cord-005453-4057qib7 8666 16 of of IN cord-005453-4057qib7 8666 17 a a DT cord-005453-4057qib7 8666 18 pediatric pediatric JJ cord-005453-4057qib7 8666 19 AML AML NNP cord-005453-4057qib7 8666 20 patient patient NN cord-005453-4057qib7 8666 21 with with IN cord-005453-4057qib7 8666 22 disseminated disseminate VBN cord-005453-4057qib7 8666 23 candida candida NN cord-005453-4057qib7 8666 24 sepsis sepsis NN cord-005453-4057qib7 8666 25 , , , cord-005453-4057qib7 8666 26 bearing bear VBG cord-005453-4057qib7 8666 27 a a DT cord-005453-4057qib7 8666 28 CARD9 CARD9 NNP cord-005453-4057qib7 8666 29 mutation mutation NN cord-005453-4057qib7 8666 30 . . . cord-005453-4057qib7 8667 1 Given give VBN cord-005453-4057qib7 8667 2 the the DT cord-005453-4057qib7 8667 3 elevated elevated JJ cord-005453-4057qib7 8667 4 mortality mortality NN cord-005453-4057qib7 8667 5 risk risk NN cord-005453-4057qib7 8667 6 for for IN cord-005453-4057qib7 8667 7 IFI IFI NNP cord-005453-4057qib7 8667 8 , , , cord-005453-4057qib7 8667 9 and and CC cord-005453-4057qib7 8667 10 the the DT cord-005453-4057qib7 8667 11 apparently apparently RB cord-005453-4057qib7 8667 12 safe safe JJ cord-005453-4057qib7 8667 13 and and CC cord-005453-4057qib7 8667 14 well well RB cord-005453-4057qib7 8667 15 - - HYPH cord-005453-4057qib7 8667 16 tolerated tolerate VBN cord-005453-4057qib7 8667 17 application application NN cord-005453-4057qib7 8667 18 of of IN cord-005453-4057qib7 8667 19 IFN IFN NNP cord-005453-4057qib7 8667 20 - - HYPH cord-005453-4057qib7 8667 21 γ γ NNP cord-005453-4057qib7 8667 22 , , , cord-005453-4057qib7 8667 23 an an DT cord-005453-4057qib7 8667 24 adjuvant adjuvant NN cord-005453-4057qib7 8667 25 immunotherapy immunotherapy NN cord-005453-4057qib7 8667 26 might may MD cord-005453-4057qib7 8667 27 be be VB cord-005453-4057qib7 8667 28 considered consider VBN cord-005453-4057qib7 8667 29 . . . cord-005453-4057qib7 8668 1 Further further JJ cord-005453-4057qib7 8668 2 studies study NNS cord-005453-4057qib7 8668 3 are be VBP cord-005453-4057qib7 8668 4 needed need VBN cord-005453-4057qib7 8668 5 to to TO cord-005453-4057qib7 8668 6 define define VB cord-005453-4057qib7 8668 7 the the DT cord-005453-4057qib7 8668 8 indication indication NN cord-005453-4057qib7 8668 9 and and CC cord-005453-4057qib7 8668 10 duration duration NN cord-005453-4057qib7 8668 11 of of IN cord-005453-4057qib7 8668 12 this this DT cord-005453-4057qib7 8668 13 kind kind NN cord-005453-4057qib7 8668 14 of of IN cord-005453-4057qib7 8668 15 adjunctive adjunctive JJ cord-005453-4057qib7 8668 16 immunotherapy immunotherapy NN cord-005453-4057qib7 8668 17 . . . cord-005453-4057qib7 8669 1 Moreover moreover RB cord-005453-4057qib7 8669 2 , , , cord-005453-4057qib7 8669 3 considering consider VBG cord-005453-4057qib7 8669 4 the the DT cord-005453-4057qib7 8669 5 wide wide JJ cord-005453-4057qib7 8669 6 heterogeneity heterogeneity NN cord-005453-4057qib7 8669 7 of of IN cord-005453-4057qib7 8669 8 genetic genetic JJ cord-005453-4057qib7 8669 9 mutations mutation NNS cord-005453-4057qib7 8669 10 involved involve VBN cord-005453-4057qib7 8669 11 in in IN cord-005453-4057qib7 8669 12 IFI IFI NNP cord-005453-4057qib7 8669 13 - - HYPH cord-005453-4057qib7 8669 14 susceptibility susceptibility NN cord-005453-4057qib7 8669 15 , , , cord-005453-4057qib7 8669 16 genome genome NN cord-005453-4057qib7 8669 17 - - HYPH cord-005453-4057qib7 8669 18 wide wide JJ cord-005453-4057qib7 8669 19 expression expression NN cord-005453-4057qib7 8669 20 profiling profiling NN cord-005453-4057qib7 8669 21 might may MD cord-005453-4057qib7 8669 22 be be VB cord-005453-4057qib7 8669 23 useful useful JJ cord-005453-4057qib7 8669 24 for for IN cord-005453-4057qib7 8669 25 pediatric pediatric JJ cord-005453-4057qib7 8669 26 cancer cancer NN cord-005453-4057qib7 8669 27 patients patient NNS cord-005453-4057qib7 8669 28 , , , cord-005453-4057qib7 8669 29 as as IN cord-005453-4057qib7 8669 30 the the DT cord-005453-4057qib7 8669 31 identification identification NN cord-005453-4057qib7 8669 32 of of IN cord-005453-4057qib7 8669 33 specific specific JJ cord-005453-4057qib7 8669 34 immune immune JJ cord-005453-4057qib7 8669 35 pathways pathway NNS cord-005453-4057qib7 8669 36 might may MD cord-005453-4057qib7 8669 37 help help VB cord-005453-4057qib7 8669 38 to to TO cord-005453-4057qib7 8669 39 identify identify VB cord-005453-4057qib7 8669 40 individual individual JJ cord-005453-4057qib7 8669 41 IFIsusceptibility ifisusceptibility NN cord-005453-4057qib7 8669 42 in in IN cord-005453-4057qib7 8669 43 order order NN cord-005453-4057qib7 8669 44 to to TO cord-005453-4057qib7 8669 45 improve improve VB cord-005453-4057qib7 8669 46 the the DT cord-005453-4057qib7 8669 47 outcome outcome NN cord-005453-4057qib7 8669 48 of of IN cord-005453-4057qib7 8669 49 those those DT cord-005453-4057qib7 8669 50 high high JJ cord-005453-4057qib7 8669 51 - - HYPH cord-005453-4057qib7 8669 52 risk risk NN cord-005453-4057qib7 8669 53 patients patient NNS cord-005453-4057qib7 8669 54 . . . cord-005453-4057qib7 8670 1 [ [ -LRB- cord-005453-4057qib7 8670 2 [ [ -LRB- cord-005453-4057qib7 8670 3 P385 p385 CD cord-005453-4057qib7 8670 4 Image image NN cord-005453-4057qib7 8670 5 ] ] -RRB- cord-005453-4057qib7 8670 6 1 1 CD cord-005453-4057qib7 8670 7 . . . cord-005453-4057qib7 8671 1 Background background NN cord-005453-4057qib7 8671 2 : : : cord-005453-4057qib7 8672 1 Chronic chronic JJ cord-005453-4057qib7 8672 2 granulomatous granulomatous JJ cord-005453-4057qib7 8672 3 disease disease NN cord-005453-4057qib7 8672 4 ( ( -LRB- cord-005453-4057qib7 8672 5 CGD CGD NNP cord-005453-4057qib7 8672 6 ) ) -RRB- cord-005453-4057qib7 8672 7 is be VBZ cord-005453-4057qib7 8672 8 curable curable JJ cord-005453-4057qib7 8672 9 by by IN cord-005453-4057qib7 8672 10 allogeneic allogeneic VBG cord-005453-4057qib7 8672 11 hematopoetic hematopoetic JJ cord-005453-4057qib7 8672 12 stem stem NN cord-005453-4057qib7 8672 13 cell cell NN cord-005453-4057qib7 8672 14 transplant transplant NN cord-005453-4057qib7 8672 15 ( ( -LRB- cord-005453-4057qib7 8672 16 HSCT HSCT NNP cord-005453-4057qib7 8672 17 ) ) -RRB- cord-005453-4057qib7 8672 18 . . . cord-005453-4057qib7 8673 1 Recent recent JJ cord-005453-4057qib7 8673 2 reports report NNS cord-005453-4057qib7 8673 3 of of IN cord-005453-4057qib7 8673 4 haploidentical haploidentical JJ cord-005453-4057qib7 8673 5 donor donor NN cord-005453-4057qib7 8673 6 HSCT HSCT NNP cord-005453-4057qib7 8673 7 with with IN cord-005453-4057qib7 8673 8 with with IN cord-005453-4057qib7 8673 9 post post NN cord-005453-4057qib7 8673 10 transplant transplant NN cord-005453-4057qib7 8673 11 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 8673 12 ( ( -LRB- cord-005453-4057qib7 8673 13 PTCy PTCy NNP cord-005453-4057qib7 8673 14 ) ) -RRB- cord-005453-4057qib7 8673 15 from from IN cord-005453-4057qib7 8673 16 family family NN cord-005453-4057qib7 8673 17 donors donor NNS cord-005453-4057qib7 8673 18 in in IN cord-005453-4057qib7 8673 19 pediatric pediatric JJ cord-005453-4057qib7 8673 20 primary primary JJ cord-005453-4057qib7 8673 21 immune immune JJ cord-005453-4057qib7 8673 22 deficiencies deficiency NNS cord-005453-4057qib7 8673 23 have have VBP cord-005453-4057qib7 8673 24 shown show VBN cord-005453-4057qib7 8673 25 encouraging encouraging JJ cord-005453-4057qib7 8673 26 results result NNS cord-005453-4057qib7 8673 27 . . . cord-005453-4057qib7 8674 1 However however RB cord-005453-4057qib7 8674 2 , , , cord-005453-4057qib7 8674 3 it -PRON- PRP cord-005453-4057qib7 8674 4 has have VBZ cord-005453-4057qib7 8674 5 not not RB cord-005453-4057qib7 8674 6 been be VBN cord-005453-4057qib7 8674 7 reported report VBN cord-005453-4057qib7 8674 8 in in IN cord-005453-4057qib7 8674 9 CGD CGD NNP cord-005453-4057qib7 8674 10 . . . cord-005453-4057qib7 8675 1 Here here RB cord-005453-4057qib7 8675 2 we -PRON- PRP cord-005453-4057qib7 8675 3 describe describe VBP cord-005453-4057qib7 8675 4 successful successful JJ cord-005453-4057qib7 8675 5 haploidentical haploidentical JJ cord-005453-4057qib7 8675 6 HSCT HSCT NNP cord-005453-4057qib7 8675 7 in in IN cord-005453-4057qib7 8675 8 a a DT cord-005453-4057qib7 8675 9 child child NN cord-005453-4057qib7 8675 10 with with IN cord-005453-4057qib7 8675 11 CGD CGD NNP cord-005453-4057qib7 8675 12 with with IN cord-005453-4057qib7 8675 13 myeloablative myeloablative JJ cord-005453-4057qib7 8675 14 conditioning conditioning NN cord-005453-4057qib7 8675 15 and and CC cord-005453-4057qib7 8675 16 PTCy PTCy NNS cord-005453-4057qib7 8675 17 . . . cord-005453-4057qib7 8676 1 A a DT cord-005453-4057qib7 8676 2 3 3 CD cord-005453-4057qib7 8676 3 year year NN cord-005453-4057qib7 8676 4 - - HYPH cord-005453-4057qib7 8676 5 old old JJ cord-005453-4057qib7 8676 6 , , , cord-005453-4057qib7 8676 7 male male JJ cord-005453-4057qib7 8676 8 child child NN cord-005453-4057qib7 8676 9 diagnosed diagnose VBN cord-005453-4057qib7 8676 10 with with IN cord-005453-4057qib7 8676 11 CGD CGD NNP cord-005453-4057qib7 8676 12 showed show VBD cord-005453-4057qib7 8676 13 oxidative oxidative JJ cord-005453-4057qib7 8676 14 activity activity NN cord-005453-4057qib7 8676 15 0.3 0.3 CD cord-005453-4057qib7 8676 16 % % NN cord-005453-4057qib7 8676 17 by by IN cord-005453-4057qib7 8676 18 dihydrorhodamine dihydrorhodamine NNP cord-005453-4057qib7 8676 19 ( ( -LRB- cord-005453-4057qib7 8676 20 DHR DHR NNP cord-005453-4057qib7 8676 21 ) ) -RRB- cord-005453-4057qib7 8676 22 test test NN cord-005453-4057qib7 8676 23 . . . cord-005453-4057qib7 8677 1 He -PRON- PRP cord-005453-4057qib7 8677 2 had have VBD cord-005453-4057qib7 8677 3 no no DT cord-005453-4057qib7 8677 4 matched match VBN cord-005453-4057qib7 8677 5 related related JJ cord-005453-4057qib7 8677 6 or or CC cord-005453-4057qib7 8677 7 unrelated unrelated JJ cord-005453-4057qib7 8677 8 donor donor NN cord-005453-4057qib7 8677 9 available available JJ cord-005453-4057qib7 8677 10 so so RB cord-005453-4057qib7 8677 11 underwent undergo VBD cord-005453-4057qib7 8677 12 haploidentical haploidentical JJ cord-005453-4057qib7 8677 13 HSCT HSCT NNP cord-005453-4057qib7 8677 14 after after IN cord-005453-4057qib7 8677 15 taking take VBG cord-005453-4057qib7 8677 16 informed informed JJ cord-005453-4057qib7 8677 17 consent consent NN cord-005453-4057qib7 8677 18 of of IN cord-005453-4057qib7 8677 19 the the DT cord-005453-4057qib7 8677 20 parents parent NNS cord-005453-4057qib7 8677 21 in in IN cord-005453-4057qib7 8677 22 May May NNP cord-005453-4057qib7 8677 23 2018 2018 CD cord-005453-4057qib7 8677 24 . . . cord-005453-4057qib7 8678 1 Donor donor NN cord-005453-4057qib7 8678 2 was be VBD cord-005453-4057qib7 8678 3 his -PRON- PRP$ cord-005453-4057qib7 8678 4 5/10 5/10 CD cord-005453-4057qib7 8678 5 HLA HLA NNP cord-005453-4057qib7 8678 6 matched match VBN cord-005453-4057qib7 8678 7 healthy healthy JJ cord-005453-4057qib7 8678 8 elder eld JJR cord-005453-4057qib7 8678 9 sister sister NN cord-005453-4057qib7 8678 10 ( ( -LRB- cord-005453-4057qib7 8678 11 oxidative oxidative JJ cord-005453-4057qib7 8678 12 activity activity NN cord-005453-4057qib7 8678 13 55 55 CD cord-005453-4057qib7 8678 14 % % NN cord-005453-4057qib7 8678 15 by by IN cord-005453-4057qib7 8678 16 DHR DHR NNP cord-005453-4057qib7 8678 17 ) ) -RRB- cord-005453-4057qib7 8678 18 . . . cord-005453-4057qib7 8679 1 He -PRON- PRP cord-005453-4057qib7 8679 2 has have VBZ cord-005453-4057qib7 8679 3 had have VBN cord-005453-4057qib7 8679 4 multiple multiple JJ cord-005453-4057qib7 8679 5 admissions admission NNS cord-005453-4057qib7 8679 6 for for IN cord-005453-4057qib7 8679 7 recurrent recurrent JJ cord-005453-4057qib7 8679 8 pneumonia pneumonia NN cord-005453-4057qib7 8679 9 prior prior RB cord-005453-4057qib7 8679 10 to to IN cord-005453-4057qib7 8679 11 HSCT HSCT NNP cord-005453-4057qib7 8679 12 . . . cord-005453-4057qib7 8680 1 The the DT cord-005453-4057qib7 8680 2 conditioning conditioning NN cord-005453-4057qib7 8680 3 was be VBD cord-005453-4057qib7 8680 4 with with IN cord-005453-4057qib7 8680 5 Rituximab Rituximab NNP cord-005453-4057qib7 8680 6 100 100 CD cord-005453-4057qib7 8680 7 mg mg NNP cord-005453-4057qib7 8680 8 / / SYM cord-005453-4057qib7 8680 9 m2 m2 NNP cord-005453-4057qib7 8680 10 IV IV NNP cord-005453-4057qib7 8680 11 on on IN cord-005453-4057qib7 8680 12 day day NN cord-005453-4057qib7 8680 13 -8 -8 NNPS cord-005453-4057qib7 8680 14 , , , cord-005453-4057qib7 8681 1 Thiotepa Thiotepa NNP cord-005453-4057qib7 8681 2 10 10 CD cord-005453-4057qib7 8681 3 mg/ mg/ NN cord-005453-4057qib7 8681 4 kg kg NNP cord-005453-4057qib7 8681 5 / / SYM cord-005453-4057qib7 8681 6 dose dose NN cord-005453-4057qib7 8681 7 intravenous intravenous JJ cord-005453-4057qib7 8681 8 ( ( -LRB- cord-005453-4057qib7 8681 9 IV IV NNP cord-005453-4057qib7 8681 10 ) ) -RRB- cord-005453-4057qib7 8681 11 for for IN cord-005453-4057qib7 8681 12 1 1 CD cord-005453-4057qib7 8681 13 day day NN cord-005453-4057qib7 8681 14 ( ( -LRB- cord-005453-4057qib7 8681 15 Day-7 Day-7 NNP cord-005453-4057qib7 8681 16 ) ) -RRB- cord-005453-4057qib7 8681 17 , , , cord-005453-4057qib7 8681 18 Busulfan Busulfan NNP cord-005453-4057qib7 8681 19 3.2 3.2 CD cord-005453-4057qib7 8681 20 mg mg NNP cord-005453-4057qib7 8681 21 / / SYM cord-005453-4057qib7 8681 22 kg kg NNP cord-005453-4057qib7 8681 23 / / SYM cord-005453-4057qib7 8681 24 dose dose VBD cord-005453-4057qib7 8681 25 daily daily JJ cord-005453-4057qib7 8681 26 IV IV NNP cord-005453-4057qib7 8681 27 for for IN cord-005453-4057qib7 8681 28 4 4 CD cord-005453-4057qib7 8681 29 days day NNS cord-005453-4057qib7 8681 30 ( ( -LRB- cord-005453-4057qib7 8681 31 Day day NN cord-005453-4057qib7 8681 32 -6 -6 JJ cord-005453-4057qib7 8681 33 to to IN cord-005453-4057qib7 8681 34 -3 -3 NNP cord-005453-4057qib7 8681 35 ) ) -RRB- cord-005453-4057qib7 8681 36 and and CC cord-005453-4057qib7 8681 37 Fludarabine Fludarabine NNP cord-005453-4057qib7 8681 38 40 40 CD cord-005453-4057qib7 8682 1 mg mg NNP cord-005453-4057qib7 8682 2 / / SYM cord-005453-4057qib7 8682 3 m2 m2 NNP cord-005453-4057qib7 8682 4 / / SYM cord-005453-4057qib7 8682 5 dose dose VBD cord-005453-4057qib7 8682 6 daily daily JJ cord-005453-4057qib7 8682 7 IV IV NNP cord-005453-4057qib7 8682 8 for for IN cord-005453-4057qib7 8682 9 4 4 CD cord-005453-4057qib7 8682 10 days day NNS cord-005453-4057qib7 8682 11 ( ( -LRB- cord-005453-4057qib7 8682 12 Day day NN cord-005453-4057qib7 8682 13 -6 -6 JJ cord-005453-4057qib7 8682 14 to to IN cord-005453-4057qib7 8682 15 -3 -3 NNP cord-005453-4057qib7 8682 16 ) ) -RRB- cord-005453-4057qib7 8682 17 and and CC cord-005453-4057qib7 8682 18 rabbit rabbit NN cord-005453-4057qib7 8682 19 anti anti JJ cord-005453-4057qib7 8682 20 - - JJ cord-005453-4057qib7 8682 21 thymoglubulin thymoglubulin JJ cord-005453-4057qib7 8682 22 ( ( -LRB- cord-005453-4057qib7 8682 23 thymoglobulin thymoglobulin NNP cord-005453-4057qib7 8682 24 ) ) -RRB- cord-005453-4057qib7 8683 1 1.5 1.5 CD cord-005453-4057qib7 8683 2 mg/ mg/ NN cord-005453-4057qib7 8683 3 kg kg NNP cord-005453-4057qib7 8683 4 / / SYM cord-005453-4057qib7 8683 5 dose dose VBD cord-005453-4057qib7 8683 6 daily daily RB cord-005453-4057qib7 8683 7 for for IN cord-005453-4057qib7 8683 8 3 3 CD cord-005453-4057qib7 8683 9 days day NNS cord-005453-4057qib7 8683 10 ( ( -LRB- cord-005453-4057qib7 8683 11 Day-4 Day-4 NNP cord-005453-4057qib7 8683 12 to to IN cord-005453-4057qib7 8683 13 -2 -2 NNP cord-005453-4057qib7 8683 14 ) ) -RRB- cord-005453-4057qib7 8683 15 . . . cord-005453-4057qib7 8684 1 Peripheral peripheral JJ cord-005453-4057qib7 8684 2 blood blood NN cord-005453-4057qib7 8684 3 stem stem NN cord-005453-4057qib7 8684 4 cells cell NNS cord-005453-4057qib7 8684 5 ( ( -LRB- cord-005453-4057qib7 8684 6 8 8 CD cord-005453-4057qib7 8684 7 million million CD cord-005453-4057qib7 8684 8 / / SYM cord-005453-4057qib7 8684 9 kg kg NN cord-005453-4057qib7 8684 10 CD34 CD34 NNP cord-005453-4057qib7 8684 11 + + CC cord-005453-4057qib7 8684 12 cells cell NNS cord-005453-4057qib7 8684 13 ) ) -RRB- cord-005453-4057qib7 8684 14 were be VBD cord-005453-4057qib7 8684 15 harvested harvest VBN cord-005453-4057qib7 8684 16 from from IN cord-005453-4057qib7 8684 17 his -PRON- PRP$ cord-005453-4057qib7 8684 18 sister sister NN cord-005453-4057qib7 8684 19 and and CC cord-005453-4057qib7 8684 20 transfused transfuse VBD cord-005453-4057qib7 8684 21 to to IN cord-005453-4057qib7 8684 22 the the DT cord-005453-4057qib7 8684 23 patient patient NN cord-005453-4057qib7 8684 24 on on IN cord-005453-4057qib7 8684 25 Day day NN cord-005453-4057qib7 8684 26 0 0 CD cord-005453-4057qib7 8684 27 . . . cord-005453-4057qib7 8685 1 Graft graft NN cord-005453-4057qib7 8685 2 vs. vs. IN cord-005453-4057qib7 8685 3 Host host NN cord-005453-4057qib7 8685 4 disease disease NN cord-005453-4057qib7 8685 5 ( ( -LRB- cord-005453-4057qib7 8685 6 GVHD GVHD NNP cord-005453-4057qib7 8685 7 ) ) -RRB- cord-005453-4057qib7 8685 8 prophylaxis prophylaxis NN cord-005453-4057qib7 8685 9 was be VBD cord-005453-4057qib7 8685 10 with with IN cord-005453-4057qib7 8685 11 PTCy PTCy NNPS cord-005453-4057qib7 8685 12 50 50 CD cord-005453-4057qib7 8685 13 mg/ mg/ NN cord-005453-4057qib7 8685 14 kg kg NNS cord-005453-4057qib7 8685 15 on on IN cord-005453-4057qib7 8685 16 Day+3 Day+3 NNP cord-005453-4057qib7 8685 17 & & CC cord-005453-4057qib7 8685 18 4 4 CD cord-005453-4057qib7 8685 19 , , , cord-005453-4057qib7 8685 20 intravenous intravenous JJ cord-005453-4057qib7 8685 21 cyclosporine cyclosporine NN cord-005453-4057qib7 8685 22 from from IN cord-005453-4057qib7 8686 1 day-3 day-3 NNP cord-005453-4057qib7 8686 2 ( ( -LRB- cord-005453-4057qib7 8686 3 targeting target VBG cord-005453-4057qib7 8686 4 levels level NNS cord-005453-4057qib7 8686 5 150 150 CD cord-005453-4057qib7 8686 6 - - SYM cord-005453-4057qib7 8686 7 250 250 CD cord-005453-4057qib7 8686 8 ng ng NN cord-005453-4057qib7 8686 9 / / SYM cord-005453-4057qib7 8686 10 ml ml NN cord-005453-4057qib7 8686 11 ) ) -RRB- cord-005453-4057qib7 8686 12 and and CC cord-005453-4057qib7 8686 13 MMF mmf NN cord-005453-4057qib7 8686 14 from from IN cord-005453-4057qib7 8686 15 day+5 day+5 NNP cord-005453-4057qib7 8686 16 . . . cord-005453-4057qib7 8687 1 Results result NNS cord-005453-4057qib7 8687 2 : : : cord-005453-4057qib7 8688 1 His -PRON- PRP$ cord-005453-4057qib7 8688 2 neutrophils neutrophil NNS cord-005453-4057qib7 8688 3 engrafted engraft VBD cord-005453-4057qib7 8688 4 on on IN cord-005453-4057qib7 8688 5 day+15 day+15 NNP cord-005453-4057qib7 8688 6 and and CC cord-005453-4057qib7 8688 7 platelets platelet NNS cord-005453-4057qib7 8688 8 on on IN cord-005453-4057qib7 8688 9 day+17 day+17 CD cord-005453-4057qib7 8688 10 . . . cord-005453-4057qib7 8689 1 Chimerism chimerism NN cord-005453-4057qib7 8689 2 on on IN cord-005453-4057qib7 8689 3 day+30 day+30 CD cord-005453-4057qib7 8689 4 , , , cord-005453-4057qib7 8689 5 100 100 CD cord-005453-4057qib7 8689 6 and and CC cord-005453-4057qib7 8689 7 6 6 CD cord-005453-4057qib7 8689 8 months month NNS cord-005453-4057qib7 8689 9 was be VBD cord-005453-4057qib7 8689 10 fully fully RB cord-005453-4057qib7 8689 11 donor donor NN cord-005453-4057qib7 8689 12 . . . cord-005453-4057qib7 8690 1 He -PRON- PRP cord-005453-4057qib7 8690 2 developed develop VBD cord-005453-4057qib7 8690 3 no no DT cord-005453-4057qib7 8690 4 acute acute JJ cord-005453-4057qib7 8690 5 or or CC cord-005453-4057qib7 8690 6 chronic chronic JJ cord-005453-4057qib7 8690 7 GVHD GVHD NNP cord-005453-4057qib7 8690 8 . . . cord-005453-4057qib7 8691 1 At at IN cord-005453-4057qib7 8691 2 6 6 CD cord-005453-4057qib7 8691 3 months month NNS cord-005453-4057qib7 8691 4 his -PRON- PRP$ cord-005453-4057qib7 8691 5 lymphocyte lymphocyte NN cord-005453-4057qib7 8691 6 counts count NNS cord-005453-4057qib7 8691 7 showed show VBD cord-005453-4057qib7 8691 8 CD4 CD4 NNP cord-005453-4057qib7 8691 9 - - HYPH cord-005453-4057qib7 8691 10 280 280 CD cord-005453-4057qib7 8691 11 / / SYM cord-005453-4057qib7 8691 12 ul ul NN cord-005453-4057qib7 8691 13 , , , cord-005453-4057qib7 8691 14 CD8 CD8 NNP cord-005453-4057qib7 8691 15 - - HYPH cord-005453-4057qib7 8691 16 670 670 NNP cord-005453-4057qib7 8691 17 / / SYM cord-005453-4057qib7 8691 18 ul ul NN cord-005453-4057qib7 8691 19 , , , cord-005453-4057qib7 8691 20 CD19 CD19 NNP cord-005453-4057qib7 8691 21 - - HYPH cord-005453-4057qib7 8691 22 15 15 CD cord-005453-4057qib7 8691 23 / / SYM cord-005453-4057qib7 8691 24 ul ul NN cord-005453-4057qib7 8692 1 and and CC cord-005453-4057qib7 8692 2 CD16/56 cd16/56 CD cord-005453-4057qib7 8692 3 - - HYPH cord-005453-4057qib7 8692 4 120 120 CD cord-005453-4057qib7 8692 5 / / SYM cord-005453-4057qib7 8692 6 ul ul NN cord-005453-4057qib7 8692 7 . . . cord-005453-4057qib7 8693 1 His -PRON- PRP$ cord-005453-4057qib7 8693 2 had have VBD cord-005453-4057qib7 8693 3 no no DT cord-005453-4057qib7 8693 4 viral viral JJ cord-005453-4057qib7 8693 5 reactivation reactivation NN cord-005453-4057qib7 8693 6 . . . cord-005453-4057qib7 8694 1 He -PRON- PRP cord-005453-4057qib7 8694 2 is be VBZ cord-005453-4057qib7 8694 3 disease disease NN cord-005453-4057qib7 8694 4 free free JJ cord-005453-4057qib7 8694 5 and and CC cord-005453-4057qib7 8694 6 GVHD GVHD NNP cord-005453-4057qib7 8694 7 free free JJ cord-005453-4057qib7 8694 8 on on IN cord-005453-4057qib7 8694 9 day+190 day+190 . cord-005453-4057qib7 8695 1 post post NNP cord-005453-4057qib7 8695 2 HSCT HSCT NNP cord-005453-4057qib7 8695 3 and and CC cord-005453-4057qib7 8695 4 is be VBZ cord-005453-4057qib7 8695 5 on on IN cord-005453-4057qib7 8695 6 tapering taper VBG cord-005453-4057qib7 8695 7 doses dose NNS cord-005453-4057qib7 8695 8 of of IN cord-005453-4057qib7 8695 9 cyclosporine cyclosporine NN cord-005453-4057qib7 8695 10 . . . cord-005453-4057qib7 8696 1 His -PRON- PRP$ cord-005453-4057qib7 8696 2 DHR DHR NNP cord-005453-4057qib7 8696 3 test test NN cord-005453-4057qib7 8696 4 showed show VBD cord-005453-4057qib7 8696 5 oxidative oxidative JJ cord-005453-4057qib7 8696 6 activity activity NN cord-005453-4057qib7 8696 7 of of IN cord-005453-4057qib7 8696 8 42 42 CD cord-005453-4057qib7 8696 9 % % NN cord-005453-4057qib7 8696 10 on on IN cord-005453-4057qib7 8696 11 day day NN cord-005453-4057qib7 8696 12 +100 +100 NNS cord-005453-4057qib7 8696 13 . . . cord-005453-4057qib7 8697 1 Background background NN cord-005453-4057qib7 8697 2 : : : cord-005453-4057qib7 8698 1 Primary primary JJ cord-005453-4057qib7 8698 2 immune immune JJ cord-005453-4057qib7 8698 3 deficiencies deficiency NNS cord-005453-4057qib7 8698 4 ( ( -LRB- cord-005453-4057qib7 8698 5 PID PID NNP cord-005453-4057qib7 8698 6 ) ) -RRB- cord-005453-4057qib7 8698 7 are be VBP cord-005453-4057qib7 8698 8 a a DT cord-005453-4057qib7 8698 9 functional functional JJ cord-005453-4057qib7 8698 10 disorder disorder NN cord-005453-4057qib7 8698 11 of of IN cord-005453-4057qib7 8698 12 inheritance inheritance NN cord-005453-4057qib7 8698 13 immune immune NN cord-005453-4057qib7 8698 14 system system NN cord-005453-4057qib7 8698 15 that that WDT cord-005453-4057qib7 8698 16 increase increase VBP cord-005453-4057qib7 8698 17 predisposition predisposition NN cord-005453-4057qib7 8698 18 to to IN cord-005453-4057qib7 8698 19 infectious infectious JJ cord-005453-4057qib7 8698 20 disease disease NN cord-005453-4057qib7 8698 21 in in IN cord-005453-4057qib7 8698 22 number number NN cord-005453-4057qib7 8698 23 and and CC cord-005453-4057qib7 8698 24 severity severity NN cord-005453-4057qib7 8698 25 . . . cord-005453-4057qib7 8699 1 The the DT cord-005453-4057qib7 8699 2 incidence incidence NN cord-005453-4057qib7 8699 3 is be VBZ cord-005453-4057qib7 8699 4 1 1 CD cord-005453-4057qib7 8699 5 : : : cord-005453-4057qib7 8699 6 10,000 10,000 CD cord-005453-4057qib7 8699 7 birth birth NN cord-005453-4057qib7 8699 8 live live RB cord-005453-4057qib7 8699 9 ; ; : cord-005453-4057qib7 8699 10 its -PRON- PRP$ cord-005453-4057qib7 8699 11 immunological immunological JJ cord-005453-4057qib7 8699 12 dysregulation dysregulation NN cord-005453-4057qib7 8699 13 may may MD cord-005453-4057qib7 8699 14 increase increase VB cord-005453-4057qib7 8699 15 the the DT cord-005453-4057qib7 8699 16 predisposition predisposition NN cord-005453-4057qib7 8699 17 of of IN cord-005453-4057qib7 8699 18 autoimmune autoimmune JJ cord-005453-4057qib7 8699 19 diseases disease NNS cord-005453-4057qib7 8699 20 and and CC cord-005453-4057qib7 8699 21 malignancy malignancy NN cord-005453-4057qib7 8699 22 , , , cord-005453-4057qib7 8699 23 the the DT cord-005453-4057qib7 8699 24 latter latter JJ cord-005453-4057qib7 8699 25 being be VBG cord-005453-4057qib7 8699 26 more more RBR cord-005453-4057qib7 8699 27 frequent frequent JJ cord-005453-4057qib7 8699 28 ( ( -LRB- cord-005453-4057qib7 8699 29 4 4 CD cord-005453-4057qib7 8699 30 - - SYM cord-005453-4057qib7 8699 31 25 25 CD cord-005453-4057qib7 8699 32 % % NN cord-005453-4057qib7 8699 33 ) ) -RRB- cord-005453-4057qib7 8699 34 . . . cord-005453-4057qib7 8700 1 At at IN cord-005453-4057qib7 8700 2 present present NN cord-005453-4057qib7 8700 3 , , , cord-005453-4057qib7 8700 4 the the DT cord-005453-4057qib7 8700 5 only only JJ cord-005453-4057qib7 8700 6 curative curative JJ cord-005453-4057qib7 8700 7 treatment treatment NN cord-005453-4057qib7 8700 8 is be VBZ cord-005453-4057qib7 8700 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 8700 10 stem stem NN cord-005453-4057qib7 8700 11 cells cell NNS cord-005453-4057qib7 8700 12 transplant transplant NN cord-005453-4057qib7 8700 13 ( ( -LRB- cord-005453-4057qib7 8700 14 HSCT HSCT NNP cord-005453-4057qib7 8700 15 ) ) -RRB- cord-005453-4057qib7 8700 16 . . . cord-005453-4057qib7 8701 1 Methods method NNS cord-005453-4057qib7 8701 2 : : : cord-005453-4057qib7 8702 1 We -PRON- PRP cord-005453-4057qib7 8702 2 describe describe VBP cord-005453-4057qib7 8702 3 all all DT cord-005453-4057qib7 8702 4 patients patient NNS cord-005453-4057qib7 8702 5 transplanted transplant VBN cord-005453-4057qib7 8702 6 with with IN cord-005453-4057qib7 8702 7 Primary Primary NNP cord-005453-4057qib7 8702 8 Immune Immune NNP cord-005453-4057qib7 8702 9 Deficiencies Deficiencies NNPS cord-005453-4057qib7 8702 10 at at IN cord-005453-4057qib7 8702 11 Instituto Instituto NNP cord-005453-4057qib7 8702 12 Nacional Nacional NNP cord-005453-4057qib7 8702 13 de de NNP cord-005453-4057qib7 8702 14 Pediatria Pediatria NNP cord-005453-4057qib7 8702 15 . . . cord-005453-4057qib7 8703 1 The the DT cord-005453-4057qib7 8703 2 conditioning conditioning NN cord-005453-4057qib7 8703 3 regimen regimen NN cord-005453-4057qib7 8703 4 depended depend VBD cord-005453-4057qib7 8703 5 on on IN cord-005453-4057qib7 8703 6 the the DT cord-005453-4057qib7 8703 7 type type NN cord-005453-4057qib7 8703 8 donor donor NN cord-005453-4057qib7 8703 9 and and CC cord-005453-4057qib7 8703 10 pathology pathology NN cord-005453-4057qib7 8703 11 : : : cord-005453-4057qib7 8703 12 myeloablative myeloablative NNP cord-005453-4057qib7 8703 13 ( ( -LRB- cord-005453-4057qib7 8703 14 41.07 41.07 CD cord-005453-4057qib7 8703 15 % % NN cord-005453-4057qib7 8703 16 ) ) -RRB- cord-005453-4057qib7 8703 17 , , , cord-005453-4057qib7 8703 18 reduced reduce VBN cord-005453-4057qib7 8703 19 intensity intensity NN cord-005453-4057qib7 8703 20 ( ( -LRB- cord-005453-4057qib7 8703 21 37.5 37.5 CD cord-005453-4057qib7 8703 22 % % NN cord-005453-4057qib7 8703 23 ) ) -RRB- cord-005453-4057qib7 8703 24 and and CC cord-005453-4057qib7 8703 25 non non NNP cord-005453-4057qib7 8703 26 myeloablative myeloablative NNP cord-005453-4057qib7 8703 27 ( ( -LRB- cord-005453-4057qib7 8703 28 21.43 21.43 CD cord-005453-4057qib7 8703 29 % % NN cord-005453-4057qib7 8703 30 ) ) -RRB- cord-005453-4057qib7 8703 31 without without IN cord-005453-4057qib7 8703 32 modification modification NN cord-005453-4057qib7 8703 33 statistically statistically RB cord-005453-4057qib7 8703 34 significantly significantly RB cord-005453-4057qib7 8703 35 in in IN cord-005453-4057qib7 8703 36 overall overall JJ cord-005453-4057qib7 8703 37 survival survival NN cord-005453-4057qib7 8703 38 . . . cord-005453-4057qib7 8704 1 Results result NNS cord-005453-4057qib7 8704 2 : : : cord-005453-4057qib7 8705 1 A a DT cord-005453-4057qib7 8705 2 total total NN cord-005453-4057qib7 8705 3 of of IN cord-005453-4057qib7 8705 4 71 71 CD cord-005453-4057qib7 8705 5 patients patient NNS cord-005453-4057qib7 8705 6 were be VBD cord-005453-4057qib7 8705 7 included include VBN cord-005453-4057qib7 8705 8 from from IN cord-005453-4057qib7 8705 9 1998 1998 CD cord-005453-4057qib7 8705 10 to to IN cord-005453-4057qib7 8705 11 January/2017 january/2017 XX cord-005453-4057qib7 8705 12 . . . cord-005453-4057qib7 8706 1 Severe severe JJ cord-005453-4057qib7 8706 2 combined combine VBN cord-005453-4057qib7 8706 3 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8706 4 ( ( -LRB- cord-005453-4057qib7 8706 5 SCID SCID NNP cord-005453-4057qib7 8706 6 ) ) -RRB- cord-005453-4057qib7 8706 7 is be VBZ cord-005453-4057qib7 8706 8 the the DT cord-005453-4057qib7 8706 9 pathology pathology NN cord-005453-4057qib7 8706 10 most most RBS cord-005453-4057qib7 8706 11 frequently frequently RB cord-005453-4057qib7 8706 12 transplanted transplant VBN cord-005453-4057qib7 8706 13 ( ( -LRB- cord-005453-4057qib7 8706 14 Figure figure NN cord-005453-4057qib7 8706 15 1 1 CD cord-005453-4057qib7 8706 16 ) ) -RRB- cord-005453-4057qib7 8706 17 . . . cord-005453-4057qib7 8707 1 Seventy seventy CD cord-005453-4057qib7 8707 2 three three CD cord-005453-4057qib7 8707 3 percent percent NN cord-005453-4057qib7 8707 4 have have VBP cord-005453-4057qib7 8707 5 molecular molecular JJ cord-005453-4057qib7 8707 6 diagnosis diagnosis NN cord-005453-4057qib7 8707 7 , , , cord-005453-4057qib7 8707 8 and and CC cord-005453-4057qib7 8707 9 44.83 44.83 CD cord-005453-4057qib7 8707 10 % % NN cord-005453-4057qib7 8707 11 have have VBP cord-005453-4057qib7 8707 12 cases case NNS cord-005453-4057qib7 8707 13 of of IN cord-005453-4057qib7 8707 14 family family NN cord-005453-4057qib7 8707 15 PID PID NNP cord-005453-4057qib7 8707 16 . . . cord-005453-4057qib7 8708 1 The the DT cord-005453-4057qib7 8708 2 most most RBS cord-005453-4057qib7 8708 3 used use VBN cord-005453-4057qib7 8708 4 sources source NNS cord-005453-4057qib7 8708 5 were be VBD cord-005453-4057qib7 8708 6 umbilical umbilical JJ cord-005453-4057qib7 8708 7 cord cord NN cord-005453-4057qib7 8708 8 blood blood NN cord-005453-4057qib7 8708 9 ( ( -LRB- cord-005453-4057qib7 8708 10 UCB UCB NNP cord-005453-4057qib7 8708 11 ) ) -RRB- cord-005453-4057qib7 8708 12 with with IN cord-005453-4057qib7 8708 13 42.6 42.6 CD cord-005453-4057qib7 8708 14 % % NN cord-005453-4057qib7 8708 15 and and CC cord-005453-4057qib7 8708 16 peripheral peripheral JJ cord-005453-4057qib7 8708 17 blood blood NN cord-005453-4057qib7 8708 18 ( ( -LRB- cord-005453-4057qib7 8708 19 39.3 39.3 CD cord-005453-4057qib7 8708 20 % % NN cord-005453-4057qib7 8708 21 ) ) -RRB- cord-005453-4057qib7 8708 22 , , . cord-005453-4057qib7 8709 1 however however RB cord-005453-4057qib7 8709 2 the the DT cord-005453-4057qib7 8709 3 trend trend NN cord-005453-4057qib7 8709 4 of of IN cord-005453-4057qib7 8709 5 the the DT cord-005453-4057qib7 8709 6 source source NN cord-005453-4057qib7 8709 7 of of IN cord-005453-4057qib7 8709 8 obtaining obtain VBG cord-005453-4057qib7 8709 9 it -PRON- PRP cord-005453-4057qib7 8709 10 has have VBZ cord-005453-4057qib7 8709 11 been be VBN cord-005453-4057qib7 8709 12 modified modify VBN cord-005453-4057qib7 8709 13 a a DT cord-005453-4057qib7 8709 14 few few JJ cord-005453-4057qib7 8709 15 years year NNS cord-005453-4057qib7 8709 16 ago ago RB cord-005453-4057qib7 8710 1 ( ( -LRB- cord-005453-4057qib7 8710 2 Figure figure NN cord-005453-4057qib7 8710 3 2 2 CD cord-005453-4057qib7 8710 4 ) ) -RRB- cord-005453-4057qib7 8710 5 . . . cord-005453-4057qib7 8711 1 The the DT cord-005453-4057qib7 8711 2 median median JJ cord-005453-4057qib7 8711 3 graft graft NN cord-005453-4057qib7 8711 4 was be VBD cord-005453-4057qib7 8711 5 14 14 CD cord-005453-4057qib7 8711 6 days day NNS cord-005453-4057qib7 8711 7 for for IN cord-005453-4057qib7 8711 8 UCB UCB NNP cord-005453-4057qib7 8711 9 , , , cord-005453-4057qib7 8711 10 16 16 CD cord-005453-4057qib7 8711 11 days day NNS cord-005453-4057qib7 8711 12 for for IN cord-005453-4057qib7 8711 13 bone bone NN cord-005453-4057qib7 8711 14 marrow marrow NN cord-005453-4057qib7 8711 15 ( ( -LRB- cord-005453-4057qib7 8711 16 BM BM NNP cord-005453-4057qib7 8711 17 ) ) -RRB- cord-005453-4057qib7 8711 18 and and CC cord-005453-4057qib7 8711 19 12 12 CD cord-005453-4057qib7 8711 20 days day NNS cord-005453-4057qib7 8711 21 for for IN cord-005453-4057qib7 8711 22 peripheral peripheral JJ cord-005453-4057qib7 8711 23 blood blood NN cord-005453-4057qib7 8711 24 ( ( -LRB- cord-005453-4057qib7 8711 25 PB PB NNP cord-005453-4057qib7 8711 26 ) ) -RRB- cord-005453-4057qib7 8712 1 ( ( -LRB- cord-005453-4057qib7 8712 2 Figure figure NN cord-005453-4057qib7 8712 3 3 3 CD cord-005453-4057qib7 8712 4 ) ) -RRB- cord-005453-4057qib7 8713 1 The the DT cord-005453-4057qib7 8713 2 main main JJ cord-005453-4057qib7 8713 3 complications complication NNS cord-005453-4057qib7 8713 4 are be VBP cord-005453-4057qib7 8713 5 infectious infectious JJ cord-005453-4057qib7 8713 6 ( ( -LRB- cord-005453-4057qib7 8713 7 bacterial bacterial JJ cord-005453-4057qib7 8713 8 48.3 48.3 CD cord-005453-4057qib7 8713 9 % % NN cord-005453-4057qib7 8713 10 and and CC cord-005453-4057qib7 8713 11 viral viral JJ cord-005453-4057qib7 8713 12 39.7 39.7 CD cord-005453-4057qib7 8713 13 % % NN cord-005453-4057qib7 8713 14 ) ) -RRB- cord-005453-4057qib7 8713 15 and and CC cord-005453-4057qib7 8713 16 non non JJ cord-005453-4057qib7 8713 17 - - JJ cord-005453-4057qib7 8713 18 infectious infectious JJ cord-005453-4057qib7 8713 19 as as IN cord-005453-4057qib7 8713 20 pre pre JJ cord-005453-4057qib7 8713 21 - - JJ cord-005453-4057qib7 8713 22 graft graft JJ cord-005453-4057qib7 8713 23 syndrome syndrome NN cord-005453-4057qib7 8713 24 ( ( -LRB- cord-005453-4057qib7 8713 25 23.1 23.1 CD cord-005453-4057qib7 8713 26 % % NN cord-005453-4057qib7 8713 27 ) ) -RRB- cord-005453-4057qib7 8713 28 . . . cord-005453-4057qib7 8714 1 Conclusions conclusion NNS cord-005453-4057qib7 8714 2 : : : cord-005453-4057qib7 8715 1 The the DT cord-005453-4057qib7 8715 2 overall overall JJ cord-005453-4057qib7 8715 3 survival survival NN cord-005453-4057qib7 8715 4 was be VBD cord-005453-4057qib7 8715 5 54.1 54.1 CD cord-005453-4057qib7 8715 6 % % NN cord-005453-4057qib7 8715 7 Survival Survival NNP cord-005453-4057qib7 8715 8 according accord VBG cord-005453-4057qib7 8715 9 to to IN cord-005453-4057qib7 8715 10 pathology pathology NN cord-005453-4057qib7 8715 11 was be VBD cord-005453-4057qib7 8715 12 : : : cord-005453-4057qib7 8715 13 100 100 CD cord-005453-4057qib7 8715 14 % % NN cord-005453-4057qib7 8715 15 Chediak Chediak NNP cord-005453-4057qib7 8715 16 Higashi Higashi NNP cord-005453-4057qib7 8715 17 syndrome syndrome NN cord-005453-4057qib7 8715 18 , , , cord-005453-4057qib7 8715 19 68 68 CD cord-005453-4057qib7 8715 20 % % NN cord-005453-4057qib7 8715 21 SCID SCID NNP cord-005453-4057qib7 8715 22 , , , cord-005453-4057qib7 8715 23 66.7 66.7 CD cord-005453-4057qib7 8715 24 % % NN cord-005453-4057qib7 8715 25 Griselli Griselli NNP cord-005453-4057qib7 8715 26 syndrome syndrome NN cord-005453-4057qib7 8715 27 , , , cord-005453-4057qib7 8715 28 66.7 66.7 CD cord-005453-4057qib7 8715 29 % % NN cord-005453-4057qib7 8715 30 hyper hyper JJ cord-005453-4057qib7 8715 31 IgM IgM NNP cord-005453-4057qib7 8715 32 syndrome syndrome NN cord-005453-4057qib7 8715 33 , , , cord-005453-4057qib7 8715 34 60 60 CD cord-005453-4057qib7 8715 35 % % NN cord-005453-4057qib7 8715 36 WAS be VBD cord-005453-4057qib7 8715 37 , , , cord-005453-4057qib7 8715 38 57 57 CD cord-005453-4057qib7 8715 39 % % NN cord-005453-4057qib7 8715 40 CGD CGD NNP cord-005453-4057qib7 8715 41 , , , cord-005453-4057qib7 8715 42 50 50 CD cord-005453-4057qib7 8715 43 % % NN cord-005453-4057qib7 8715 44 Hemophagocytic hemophagocytic JJ cord-005453-4057qib7 8715 45 lymphohistiocytosis lymphohistiocytosis NN cord-005453-4057qib7 8715 46 . . . cord-005453-4057qib7 8716 1 Disclosure disclosure NN cord-005453-4057qib7 8716 2 : : : cord-005453-4057qib7 8717 1 Ramírez Ramírez NNP cord-005453-4057qib7 8717 2 - - HYPH cord-005453-4057qib7 8717 3 Uribe Uribe NNP cord-005453-4057qib7 8717 4 Rosa Rosa NNP cord-005453-4057qib7 8717 5 Maria Maria NNP cord-005453-4057qib7 8717 6 Nideshda Nideshda NNP cord-005453-4057qib7 8717 7 , , , cord-005453-4057qib7 8717 8 Salazar Salazar NNP cord-005453-4057qib7 8717 9 - - HYPH cord-005453-4057qib7 8717 10 Rosales Rosales NNP cord-005453-4057qib7 8717 11 Haydeé Haydeé NNP cord-005453-4057qib7 8717 12 , , , cord-005453-4057qib7 8717 13 Olaya Olaya NNP cord-005453-4057qib7 8717 14 - - HYPH cord-005453-4057qib7 8717 15 Vargas Vargas NNP cord-005453-4057qib7 8717 16 Alberto Alberto NNP cord-005453-4057qib7 8717 17 , , , cord-005453-4057qib7 8717 18 López López NNP cord-005453-4057qib7 8717 19 - - HYPH cord-005453-4057qib7 8717 20 Hernández Hernández NNP cord-005453-4057qib7 8717 21 Gerardo Gerardo NNP cord-005453-4057qib7 8717 22 , , , cord-005453-4057qib7 8717 23 del del NNP cord-005453-4057qib7 8717 24 Campo Campo NNP cord-005453-4057qib7 8717 25 - - HYPH cord-005453-4057qib7 8717 26 Martínez Martínez NNP cord-005453-4057qib7 8717 27 Maria Maria NNP cord-005453-4057qib7 8717 28 de de IN cord-005453-4057qib7 8717 29 los los NNP cord-005453-4057qib7 8717 30 Àngeles Àngeles NNP cord-005453-4057qib7 8718 1 We -PRON- PRP cord-005453-4057qib7 8718 2 wish wish VBP cord-005453-4057qib7 8718 3 to to TO cord-005453-4057qib7 8718 4 confirm confirm VB cord-005453-4057qib7 8718 5 that that IN cord-005453-4057qib7 8718 6 there there EX cord-005453-4057qib7 8718 7 are be VBP cord-005453-4057qib7 8718 8 no no DT cord-005453-4057qib7 8718 9 known know VBN cord-005453-4057qib7 8718 10 conflicts conflict NNS cord-005453-4057qib7 8718 11 of of IN cord-005453-4057qib7 8718 12 interest interest NN cord-005453-4057qib7 8718 13 associated associate VBN cord-005453-4057qib7 8718 14 with with IN cord-005453-4057qib7 8718 15 this this DT cord-005453-4057qib7 8718 16 abstact abstact JJ cord-005453-4057qib7 8718 17 , , , cord-005453-4057qib7 8718 18 the the DT cord-005453-4057qib7 8718 19 only only JJ cord-005453-4057qib7 8718 20 financial financial JJ cord-005453-4057qib7 8718 21 support support NN cord-005453-4057qib7 8718 22 was be VBD cord-005453-4057qib7 8718 23 provided provide VBN cord-005453-4057qib7 8718 24 by by IN cord-005453-4057qib7 8718 25 Mexican Mexican NNP cord-005453-4057qib7 8718 26 Associations Associations NNPS cord-005453-4057qib7 8718 27 that that IN cord-005453-4057qib7 8718 28 helping help VBG cord-005453-4057qib7 8718 29 children child NNS cord-005453-4057qib7 8718 30 wiht wiht VB cord-005453-4057qib7 8718 31 cancer cancer NN cord-005453-4057qib7 8718 32 in in IN cord-005453-4057qib7 8718 33 a a DT cord-005453-4057qib7 8718 34 few few JJ cord-005453-4057qib7 8718 35 patients patient NNS cord-005453-4057qib7 8718 36 . . . cord-005453-4057qib7 8719 1 Long long JJ cord-005453-4057qib7 8719 2 - - HYPH cord-005453-4057qib7 8719 3 term term NN cord-005453-4057qib7 8719 4 outcome outcome NN cord-005453-4057qib7 8719 5 following follow VBG cord-005453-4057qib7 8719 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 8719 7 stem stem NN cord-005453-4057qib7 8719 8 cell cell NN cord-005453-4057qib7 8719 9 transplantation transplantation NN cord-005453-4057qib7 8719 10 of of IN cord-005453-4057qib7 8719 11 Wiskott Wiskott NNP cord-005453-4057qib7 8719 12 - - HYPH cord-005453-4057qib7 8719 13 Aldrich Aldrich NNP cord-005453-4057qib7 8719 14 syndrome syndrome NN cord-005453-4057qib7 8719 15 in in IN cord-005453-4057qib7 8719 16 a a DT cord-005453-4057qib7 8719 17 single single JJ cord-005453-4057qib7 8719 18 institute institute NN cord-005453-4057qib7 8719 19 Mamoru Mamoru NNP cord-005453-4057qib7 8719 20 Honda Honda NNP cord-005453-4057qib7 8719 21 1,2 1,2 CD cord-005453-4057qib7 8719 22 , , , cord-005453-4057qib7 8719 23 Yukayo Yukayo NNP cord-005453-4057qib7 8719 24 Terashita Terashita NNP cord-005453-4057qib7 8719 25 1 1 CD cord-005453-4057qib7 8719 26 , , , cord-005453-4057qib7 8719 27 Minako Minako NNP cord-005453-4057qib7 8719 28 Sugiyama Sugiyama NNP cord-005453-4057qib7 8719 29 1 1 CD cord-005453-4057qib7 8719 30 , , , cord-005453-4057qib7 8719 31 Yuko Yuko NNP cord-005453-4057qib7 8719 32 Cho Cho NNP cord-005453-4057qib7 8719 33 1 1 CD cord-005453-4057qib7 8719 34 , , , cord-005453-4057qib7 8719 35 Akihiro Akihiro NNP cord-005453-4057qib7 8719 36 Iguchi Iguchi NNP cord-005453-4057qib7 8720 1 1 1 CD cord-005453-4057qib7 8720 2 Background background NN cord-005453-4057qib7 8720 3 : : : cord-005453-4057qib7 8721 1 Wiskott Wiskott NNP cord-005453-4057qib7 8721 2 - - HYPH cord-005453-4057qib7 8721 3 Aldrich Aldrich NNP cord-005453-4057qib7 8721 4 syndrome syndrome NN cord-005453-4057qib7 8721 5 ( ( -LRB- cord-005453-4057qib7 8721 6 WAS be VBD cord-005453-4057qib7 8721 7 ) ) -RRB- cord-005453-4057qib7 8721 8 is be VBZ cord-005453-4057qib7 8721 9 an an DT cord-005453-4057qib7 8721 10 Xlinked xlinked JJ cord-005453-4057qib7 8721 11 disorder disorder NN cord-005453-4057qib7 8721 12 of of IN cord-005453-4057qib7 8721 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 8721 14 cells cell NNS cord-005453-4057qib7 8721 15 , , , cord-005453-4057qib7 8721 16 characterized characterize VBN cord-005453-4057qib7 8721 17 by by IN cord-005453-4057qib7 8721 18 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 8721 19 with with IN cord-005453-4057qib7 8721 20 small small JJ cord-005453-4057qib7 8721 21 platelets platelet NNS cord-005453-4057qib7 8721 22 , , , cord-005453-4057qib7 8721 23 eczema eczema NN cord-005453-4057qib7 8721 24 , , , cord-005453-4057qib7 8721 25 and and CC cord-005453-4057qib7 8721 26 immunodeficiency immunodeficiency NN cord-005453-4057qib7 8721 27 . . . cord-005453-4057qib7 8722 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 8722 2 stem stem NN cord-005453-4057qib7 8722 3 cell cell NN cord-005453-4057qib7 8722 4 transplantation transplantation NN cord-005453-4057qib7 8722 5 ( ( -LRB- cord-005453-4057qib7 8722 6 HSCT HSCT NNP cord-005453-4057qib7 8722 7 ) ) -RRB- cord-005453-4057qib7 8722 8 is be VBZ cord-005453-4057qib7 8722 9 the the DT cord-005453-4057qib7 8722 10 only only JJ cord-005453-4057qib7 8722 11 curative curative JJ cord-005453-4057qib7 8722 12 treatment treatment NN cord-005453-4057qib7 8722 13 , , , cord-005453-4057qib7 8722 14 and and CC cord-005453-4057qib7 8722 15 it -PRON- PRP cord-005453-4057qib7 8722 16 is be VBZ cord-005453-4057qib7 8722 17 recommended recommend VBN cord-005453-4057qib7 8722 18 to to TO cord-005453-4057qib7 8722 19 be be VB cord-005453-4057qib7 8722 20 performed perform VBN cord-005453-4057qib7 8722 21 as as RB cord-005453-4057qib7 8722 22 soon soon RB cord-005453-4057qib7 8722 23 as as IN cord-005453-4057qib7 8722 24 WAS be VBD cord-005453-4057qib7 8722 25 is be VBZ cord-005453-4057qib7 8722 26 diagnosed diagnose VBN cord-005453-4057qib7 8722 27 . . . cord-005453-4057qib7 8723 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 8723 2 conditioning conditioning NN cord-005453-4057qib7 8723 3 before before IN cord-005453-4057qib7 8723 4 HSCT HSCT NNP cord-005453-4057qib7 8723 5 is be VBZ cord-005453-4057qib7 8723 6 recommended recommend VBN cord-005453-4057qib7 8723 7 because because IN cord-005453-4057qib7 8723 8 there there EX cord-005453-4057qib7 8723 9 is be VBZ cord-005453-4057qib7 8723 10 a a DT cord-005453-4057qib7 8723 11 high high JJ cord-005453-4057qib7 8723 12 risk risk NN cord-005453-4057qib7 8723 13 of of IN cord-005453-4057qib7 8723 14 development development NN cord-005453-4057qib7 8723 15 of of IN cord-005453-4057qib7 8723 16 autoimmune autoimmune JJ cord-005453-4057qib7 8723 17 disease disease NN cord-005453-4057qib7 8723 18 in in IN cord-005453-4057qib7 8723 19 patients patient NNS cord-005453-4057qib7 8723 20 with with IN cord-005453-4057qib7 8723 21 mixed mixed JJ cord-005453-4057qib7 8723 22 chimera chimera NN cord-005453-4057qib7 8723 23 after after IN cord-005453-4057qib7 8723 24 HSCT HSCT NNP cord-005453-4057qib7 8723 25 . . . cord-005453-4057qib7 8724 1 However however RB cord-005453-4057qib7 8724 2 , , , cord-005453-4057qib7 8724 3 there there EX cord-005453-4057qib7 8724 4 are be VBP cord-005453-4057qib7 8724 5 few few JJ cord-005453-4057qib7 8724 6 reports report NNS cord-005453-4057qib7 8724 7 about about IN cord-005453-4057qib7 8724 8 late late JJ cord-005453-4057qib7 8724 9 complications complication NNS cord-005453-4057qib7 8724 10 such such JJ cord-005453-4057qib7 8724 11 as as IN cord-005453-4057qib7 8724 12 pubertal pubertal JJ cord-005453-4057qib7 8724 13 development development NN cord-005453-4057qib7 8724 14 and and CC cord-005453-4057qib7 8724 15 eruption eruption NN cord-005453-4057qib7 8724 16 of of IN cord-005453-4057qib7 8724 17 teeth tooth NNS cord-005453-4057qib7 8724 18 in in IN cord-005453-4057qib7 8724 19 patients patient NNS cord-005453-4057qib7 8724 20 with with IN cord-005453-4057qib7 8724 21 WAS be VBD cord-005453-4057qib7 8724 22 receiving receive VBG cord-005453-4057qib7 8724 23 HSCT HSCT NNP cord-005453-4057qib7 8724 24 . . . cord-005453-4057qib7 8725 1 Thus thus RB cord-005453-4057qib7 8725 2 , , , cord-005453-4057qib7 8725 3 we -PRON- PRP cord-005453-4057qib7 8725 4 evaluated evaluate VBD cord-005453-4057qib7 8725 5 late late JJ cord-005453-4057qib7 8725 6 complications complication NNS cord-005453-4057qib7 8725 7 in in IN cord-005453-4057qib7 8725 8 patients patient NNS cord-005453-4057qib7 8725 9 with with IN cord-005453-4057qib7 8725 10 WAS be VBD cord-005453-4057qib7 8725 11 receiving receive VBG cord-005453-4057qib7 8725 12 HSCT HSCT NNP cord-005453-4057qib7 8725 13 at at IN cord-005453-4057qib7 8725 14 Hokkaido Hokkaido NNP cord-005453-4057qib7 8725 15 University University NNP cord-005453-4057qib7 8725 16 Hospital Hospital NNP cord-005453-4057qib7 8725 17 . . . cord-005453-4057qib7 8726 1 Methods method NNS cord-005453-4057qib7 8726 2 : : : cord-005453-4057qib7 8727 1 We -PRON- PRP cord-005453-4057qib7 8727 2 reviewed review VBD cord-005453-4057qib7 8727 3 medical medical JJ cord-005453-4057qib7 8727 4 records record NNS cord-005453-4057qib7 8727 5 of of IN cord-005453-4057qib7 8727 6 8 8 CD cord-005453-4057qib7 8727 7 male male JJ cord-005453-4057qib7 8727 8 patients patient NNS cord-005453-4057qib7 8727 9 with with IN cord-005453-4057qib7 8727 10 WAS be VBD cord-005453-4057qib7 8727 11 who who WP cord-005453-4057qib7 8727 12 received receive VBD cord-005453-4057qib7 8727 13 HSCT HSCT NNP cord-005453-4057qib7 8727 14 between between IN cord-005453-4057qib7 8727 15 1995 1995 CD cord-005453-4057qib7 8727 16 and and CC cord-005453-4057qib7 8727 17 2017 2017 CD cord-005453-4057qib7 8727 18 . . . cord-005453-4057qib7 8728 1 Results result NNS cord-005453-4057qib7 8728 2 : : : cord-005453-4057qib7 8729 1 Mean mean JJ cord-005453-4057qib7 8729 2 age age NN cord-005453-4057qib7 8729 3 at at IN cord-005453-4057qib7 8729 4 HSCT HSCT NNP cord-005453-4057qib7 8729 5 was be VBD cord-005453-4057qib7 8729 6 1.4 1.4 CD cord-005453-4057qib7 8729 7 ( ( -LRB- cord-005453-4057qib7 8729 8 range range NN cord-005453-4057qib7 8729 9 , , , cord-005453-4057qib7 8729 10 0.6 0.6 CD cord-005453-4057qib7 8729 11 - - SYM cord-005453-4057qib7 8729 12 6.8 6.8 CD cord-005453-4057qib7 8729 13 ) ) -RRB- cord-005453-4057qib7 8729 14 years year NNS cord-005453-4057qib7 8729 15 , , , cord-005453-4057qib7 8729 16 and and CC cord-005453-4057qib7 8729 17 median median JJ cord-005453-4057qib7 8729 18 follow follow NN cord-005453-4057qib7 8729 19 - - HYPH cord-005453-4057qib7 8729 20 up up NN cord-005453-4057qib7 8729 21 time time NN cord-005453-4057qib7 8729 22 after after IN cord-005453-4057qib7 8729 23 HSCT HSCT NNP cord-005453-4057qib7 8729 24 was be VBD cord-005453-4057qib7 8729 25 13.8 13.8 CD cord-005453-4057qib7 8730 1 ( ( -LRB- cord-005453-4057qib7 8730 2 range range VBP cord-005453-4057qib7 8730 3 2.9 2.9 CD cord-005453-4057qib7 8730 4 - - HYPH cord-005453-4057qib7 8730 5 23.4 23.4 CD cord-005453-4057qib7 8730 6 ) ) -RRB- cord-005453-4057qib7 8730 7 years year NNS cord-005453-4057qib7 8730 8 . . . cord-005453-4057qib7 8731 1 Conditioning conditioning NN cord-005453-4057qib7 8731 2 regimen regimen NN cord-005453-4057qib7 8731 3 in in IN cord-005453-4057qib7 8731 4 all all DT cord-005453-4057qib7 8731 5 patients patient NNS cord-005453-4057qib7 8731 6 comprised comprise VBN cord-005453-4057qib7 8731 7 busulfan busulfan NN cord-005453-4057qib7 8731 8 at at IN cord-005453-4057qib7 8731 9 4 4 CD cord-005453-4057qib7 8731 10 mg mg NNP cord-005453-4057qib7 8731 11 / / SYM cord-005453-4057qib7 8731 12 kg kg NN cord-005453-4057qib7 8731 13 for for IN cord-005453-4057qib7 8731 14 4 4 CD cord-005453-4057qib7 8731 15 days day NNS cord-005453-4057qib7 8731 16 and and CC cord-005453-4057qib7 8731 17 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 8731 18 at at IN cord-005453-4057qib7 8731 19 60 60 CD cord-005453-4057qib7 8731 20 mg mg NN cord-005453-4057qib7 8731 21 / / SYM cord-005453-4057qib7 8731 22 kg kg NNS cord-005453-4057qib7 8731 23 for for IN cord-005453-4057qib7 8731 24 2 2 CD cord-005453-4057qib7 8731 25 days day NNS cord-005453-4057qib7 8731 26 or or CC cord-005453-4057qib7 8732 1 50 50 CD cord-005453-4057qib7 8732 2 mg mg NNP cord-005453-4057qib7 8732 3 / / SYM cord-005453-4057qib7 8732 4 kg kg NN cord-005453-4057qib7 8732 5 for for IN cord-005453-4057qib7 8732 6 4 4 CD cord-005453-4057qib7 8732 7 days day NNS cord-005453-4057qib7 8732 8 . . . cord-005453-4057qib7 8733 1 Additionally additionally RB cord-005453-4057qib7 8733 2 , , , cord-005453-4057qib7 8733 3 anti anti JJ cord-005453-4057qib7 8733 4 - - JJ cord-005453-4057qib7 8733 5 thymocyte thymocyte JJ cord-005453-4057qib7 8733 6 globulin globulin NN cord-005453-4057qib7 8733 7 at at IN cord-005453-4057qib7 8733 8 2.5 2.5 CD cord-005453-4057qib7 8733 9 mg mg NNP cord-005453-4057qib7 8733 10 / / SYM cord-005453-4057qib7 8733 11 kg kg NNP cord-005453-4057qib7 8733 12 / / SYM cord-005453-4057qib7 8733 13 day day NN cord-005453-4057qib7 8733 14 for for IN cord-005453-4057qib7 8733 15 1 1 CD cord-005453-4057qib7 8733 16 - - SYM cord-005453-4057qib7 8733 17 2 2 CD cord-005453-4057qib7 8733 18 days day NNS cord-005453-4057qib7 8733 19 was be VBD cord-005453-4057qib7 8733 20 administered administer VBN cord-005453-4057qib7 8733 21 in in IN cord-005453-4057qib7 8733 22 6 6 CD cord-005453-4057qib7 8733 23 patients patient NNS cord-005453-4057qib7 8733 24 . . . cord-005453-4057qib7 8734 1 Engraftment Engraftment NNP cord-005453-4057qib7 8734 2 , , , cord-005453-4057qib7 8734 3 normal normal JJ cord-005453-4057qib7 8734 4 platelet platelet NN cord-005453-4057qib7 8734 5 count count NN cord-005453-4057qib7 8734 6 , , , cord-005453-4057qib7 8734 7 and and CC cord-005453-4057qib7 8734 8 complete complete JJ cord-005453-4057qib7 8734 9 chimera chimera NN cord-005453-4057qib7 8734 10 were be VBD cord-005453-4057qib7 8734 11 confirmed confirm VBN cord-005453-4057qib7 8734 12 in in IN cord-005453-4057qib7 8734 13 all all DT cord-005453-4057qib7 8734 14 patients patient NNS cord-005453-4057qib7 8734 15 . . . cord-005453-4057qib7 8735 1 No no DT cord-005453-4057qib7 8735 2 patients patient NNS cord-005453-4057qib7 8735 3 showed show VBD cord-005453-4057qib7 8735 4 complications complication NNS cord-005453-4057qib7 8735 5 such such JJ cord-005453-4057qib7 8735 6 as as IN cord-005453-4057qib7 8735 7 severe severe JJ cord-005453-4057qib7 8735 8 chronic chronic JJ cord-005453-4057qib7 8735 9 graft graft NN cord-005453-4057qib7 8735 10 - - HYPH cord-005453-4057qib7 8735 11 versus versus IN cord-005453-4057qib7 8735 12 - - HYPH cord-005453-4057qib7 8735 13 host host NN cord-005453-4057qib7 8735 14 disease disease NN cord-005453-4057qib7 8735 15 , , , cord-005453-4057qib7 8735 16 autoimmune autoimmune JJ cord-005453-4057qib7 8735 17 disease disease NN cord-005453-4057qib7 8735 18 , , , cord-005453-4057qib7 8735 19 short short JJ cord-005453-4057qib7 8735 20 stature stature NN cord-005453-4057qib7 8735 21 ( ( -LRB- cord-005453-4057qib7 8735 22 ≤ ≤ NN cord-005453-4057qib7 8735 23 -2.0 -2.0 HYPH cord-005453-4057qib7 8735 24 SD sd NN cord-005453-4057qib7 8735 25 ) ) -RRB- cord-005453-4057qib7 8735 26 and and CC cord-005453-4057qib7 8735 27 second second JJ cord-005453-4057qib7 8735 28 malignancy malignancy NN cord-005453-4057qib7 8735 29 . . . cord-005453-4057qib7 8736 1 However however RB cord-005453-4057qib7 8736 2 , , , cord-005453-4057qib7 8736 3 high high JJ cord-005453-4057qib7 8736 4 IgE IgE NNP cord-005453-4057qib7 8736 5 level level NN cord-005453-4057qib7 8736 6 was be VBD cord-005453-4057qib7 8736 7 observed observe VBN cord-005453-4057qib7 8736 8 in in IN cord-005453-4057qib7 8736 9 4 4 CD cord-005453-4057qib7 8736 10 patients patient NNS cord-005453-4057qib7 8736 11 . . . cord-005453-4057qib7 8737 1 Pubertal pubertal JJ cord-005453-4057qib7 8737 2 development development NN cord-005453-4057qib7 8737 3 has have VBZ cord-005453-4057qib7 8737 4 been be VBN cord-005453-4057qib7 8737 5 confirmed confirm VBN cord-005453-4057qib7 8737 6 in in IN cord-005453-4057qib7 8737 7 6 6 CD cord-005453-4057qib7 8737 8 patients patient NNS cord-005453-4057qib7 8737 9 . . . cord-005453-4057qib7 8738 1 Lack lack NN cord-005453-4057qib7 8738 2 of of IN cord-005453-4057qib7 8738 3 complete complete JJ cord-005453-4057qib7 8738 4 eruption eruption NN cord-005453-4057qib7 8738 5 of of IN cord-005453-4057qib7 8738 6 permanent permanent JJ cord-005453-4057qib7 8738 7 teeth tooth NNS cord-005453-4057qib7 8738 8 has have VBZ cord-005453-4057qib7 8738 9 been be VBN cord-005453-4057qib7 8738 10 observed observe VBN cord-005453-4057qib7 8738 11 in in IN cord-005453-4057qib7 8738 12 3 3 CD cord-005453-4057qib7 8738 13 patients patient NNS cord-005453-4057qib7 8738 14 who who WP cord-005453-4057qib7 8738 15 received receive VBD cord-005453-4057qib7 8738 16 HSCT HSCT NNP cord-005453-4057qib7 8738 17 at at IN cord-005453-4057qib7 8738 18 age age NN cord-005453-4057qib7 8738 19 of of IN cord-005453-4057qib7 8738 20 < < $ cord-005453-4057qib7 8738 21 2 2 CD cord-005453-4057qib7 8738 22 years year NNS cord-005453-4057qib7 8738 23 . . . cord-005453-4057qib7 8739 1 Conclusions conclusion NNS cord-005453-4057qib7 8739 2 : : : cord-005453-4057qib7 8740 1 Although although IN cord-005453-4057qib7 8740 2 this this DT cord-005453-4057qib7 8740 3 was be VBD cord-005453-4057qib7 8740 4 a a DT cord-005453-4057qib7 8740 5 small small JJ cord-005453-4057qib7 8740 6 - - HYPH cord-005453-4057qib7 8740 7 cohort cohort NN cord-005453-4057qib7 8740 8 study study NN cord-005453-4057qib7 8740 9 in in IN cord-005453-4057qib7 8740 10 a a DT cord-005453-4057qib7 8740 11 single single JJ cord-005453-4057qib7 8740 12 institute institute NN cord-005453-4057qib7 8740 13 , , , cord-005453-4057qib7 8740 14 complete complete JJ cord-005453-4057qib7 8740 15 chimera chimera NN cord-005453-4057qib7 8740 16 has have VBZ cord-005453-4057qib7 8740 17 been be VBN cord-005453-4057qib7 8740 18 achieved achieve VBN cord-005453-4057qib7 8740 19 in in IN cord-005453-4057qib7 8740 20 all all DT cord-005453-4057qib7 8740 21 patients patient NNS cord-005453-4057qib7 8740 22 who who WP cord-005453-4057qib7 8740 23 received receive VBD cord-005453-4057qib7 8740 24 HSCT HSCT NNP cord-005453-4057qib7 8740 25 with with IN cord-005453-4057qib7 8740 26 busulfan busulfan NN cord-005453-4057qib7 8740 27 - - HYPH cord-005453-4057qib7 8740 28 based base VBN cord-005453-4057qib7 8740 29 myeloablative myeloablative NNP cord-005453-4057qib7 8740 30 conditioning conditioning NN cord-005453-4057qib7 8740 31 . . . cord-005453-4057qib7 8741 1 However however RB cord-005453-4057qib7 8741 2 , , , cord-005453-4057qib7 8741 3 late late JJ cord-005453-4057qib7 8741 4 complications complication NNS cord-005453-4057qib7 8741 5 such such JJ cord-005453-4057qib7 8741 6 as as IN cord-005453-4057qib7 8741 7 male male JJ cord-005453-4057qib7 8741 8 infertility infertility NN cord-005453-4057qib7 8741 9 and and CC cord-005453-4057qib7 8741 10 incomplete incomplete JJ cord-005453-4057qib7 8741 11 eruption eruption NN cord-005453-4057qib7 8741 12 of of IN cord-005453-4057qib7 8741 13 permanent permanent JJ cord-005453-4057qib7 8741 14 teeth tooth NNS cord-005453-4057qib7 8741 15 remain remain VBP cord-005453-4057qib7 8741 16 major major JJ cord-005453-4057qib7 8741 17 problems problem NNS cord-005453-4057qib7 8741 18 . . . cord-005453-4057qib7 8742 1 Disclosure disclosure NN cord-005453-4057qib7 8742 2 : : : cord-005453-4057qib7 8742 3 Nothing nothing NN cord-005453-4057qib7 8742 4 to to TO cord-005453-4057qib7 8742 5 declare declare VB cord-005453-4057qib7 8742 6 Methods method NNS cord-005453-4057qib7 8742 7 : : : cord-005453-4057qib7 8742 8 We -PRON- PRP cord-005453-4057qib7 8742 9 performed perform VBD cord-005453-4057qib7 8742 10 unrelated unrelated JJ cord-005453-4057qib7 8742 11 umbilical umbilical JJ cord-005453-4057qib7 8742 12 cord cord NN cord-005453-4057qib7 8742 13 blood blood NN cord-005453-4057qib7 8742 14 transplantation transplantation NN cord-005453-4057qib7 8742 15 ( ( -LRB- cord-005453-4057qib7 8742 16 UCBT UCBT NNP cord-005453-4057qib7 8742 17 ) ) -RRB- cord-005453-4057qib7 8742 18 in in IN cord-005453-4057qib7 8742 19 5 5 CD cord-005453-4057qib7 8742 20 consecutive consecutive JJ cord-005453-4057qib7 8742 21 children child NNS cord-005453-4057qib7 8742 22 with with IN cord-005453-4057qib7 8742 23 LAD LAD NNP cord-005453-4057qib7 8742 24 - - HYPH cord-005453-4057qib7 8742 25 I. I. NNP cord-005453-4057qib7 8742 26 Median Median NNP cord-005453-4057qib7 8742 27 age age NN cord-005453-4057qib7 8742 28 of of IN cord-005453-4057qib7 8742 29 5 5 CD cord-005453-4057qib7 8742 30 children child NNS cord-005453-4057qib7 8742 31 was be VBD cord-005453-4057qib7 8742 32 13 13 CD cord-005453-4057qib7 8742 33 months month NNS cord-005453-4057qib7 8742 34 ( ( -LRB- cord-005453-4057qib7 8742 35 range range NN cord-005453-4057qib7 8742 36 , , , cord-005453-4057qib7 8742 37 8 8 CD cord-005453-4057qib7 8742 38 to to TO cord-005453-4057qib7 8742 39 131 131 CD cord-005453-4057qib7 8742 40 months month NNS cord-005453-4057qib7 8742 41 ) ) -RRB- cord-005453-4057qib7 8742 42 , , , cord-005453-4057qib7 8742 43 and and CC cord-005453-4057qib7 8742 44 median median JJ cord-005453-4057qib7 8742 45 body body NN cord-005453-4057qib7 8742 46 weight weight NN cord-005453-4057qib7 8742 47 was be VBD cord-005453-4057qib7 8742 48 13 13 CD cord-005453-4057qib7 8742 49 kg kg NN cord-005453-4057qib7 8742 50 ( ( -LRB- cord-005453-4057qib7 8742 51 range range NN cord-005453-4057qib7 8742 52 , , , cord-005453-4057qib7 8742 53 8 8 CD cord-005453-4057qib7 8742 54 to to IN cord-005453-4057qib7 8742 55 24.3 24.3 CD cord-005453-4057qib7 8742 56 kg kg NNS cord-005453-4057qib7 8742 57 ) ) -RRB- cord-005453-4057qib7 8742 58 . . . cord-005453-4057qib7 8743 1 All all DT cord-005453-4057qib7 8743 2 patients patient NNS cord-005453-4057qib7 8743 3 received receive VBD cord-005453-4057qib7 8743 4 myeloablative myeloablative NNP cord-005453-4057qib7 8743 5 conditioning conditioning NN cord-005453-4057qib7 8743 6 regimen regimen NN cord-005453-4057qib7 8743 7 consisting consist VBG cord-005453-4057qib7 8743 8 of of IN cord-005453-4057qib7 8743 9 busulfan busulfan NN cord-005453-4057qib7 8743 10 , , , cord-005453-4057qib7 8743 11 fludarabine fludarabine NN cord-005453-4057qib7 8743 12 and and CC cord-005453-4057qib7 8743 13 cytarabine cytarabine NN cord-005453-4057qib7 8743 14 . . . cord-005453-4057qib7 8744 1 Prophylaxis prophylaxis NN cord-005453-4057qib7 8744 2 for for IN cord-005453-4057qib7 8744 3 graft graft NN cord-005453-4057qib7 8744 4 - - HYPH cord-005453-4057qib7 8744 5 versus versus IN cord-005453-4057qib7 8744 6 - - HYPH cord-005453-4057qib7 8744 7 host host NN cord-005453-4057qib7 8744 8 disease disease NN cord-005453-4057qib7 8744 9 ( ( -LRB- cord-005453-4057qib7 8744 10 GVHD GVHD NNP cord-005453-4057qib7 8744 11 ) ) -RRB- cord-005453-4057qib7 8744 12 was be VBD cord-005453-4057qib7 8744 13 tacrolimus tacrolimus JJ cord-005453-4057qib7 8744 14 . . . cord-005453-4057qib7 8745 1 All all DT cord-005453-4057qib7 8745 2 patients patient NNS cord-005453-4057qib7 8745 3 received receive VBD cord-005453-4057qib7 8745 4 a a DT cord-005453-4057qib7 8745 5 ≤2 ≤2 NNP cord-005453-4057qib7 8745 6 HLA HLA NNP cord-005453-4057qib7 8745 7 alleles allele NNS cord-005453-4057qib7 8745 8 - - HYPH cord-005453-4057qib7 8745 9 mismatched mismatch VBN cord-005453-4057qib7 8745 10 cord cord NN cord-005453-4057qib7 8745 11 unit unit NN cord-005453-4057qib7 8745 12 , , , cord-005453-4057qib7 8745 13 1 1 CD cord-005453-4057qib7 8745 14 was be VBD cord-005453-4057qib7 8745 15 HLA HLA NNP cord-005453-4057qib7 8745 16 fully fully RB cord-005453-4057qib7 8745 17 matched match VBN cord-005453-4057qib7 8745 18 , , , cord-005453-4057qib7 8745 19 3 3 CD cord-005453-4057qib7 8745 20 were be VBD cord-005453-4057qib7 8745 21 9/10 9/10 CD cord-005453-4057qib7 8745 22 matched match VBN cord-005453-4057qib7 8745 23 , , , cord-005453-4057qib7 8745 24 1 1 CD cord-005453-4057qib7 8745 25 was be VBD cord-005453-4057qib7 8745 26 8/10 8/10 CD cord-005453-4057qib7 8745 27 matched match VBN cord-005453-4057qib7 8745 28 . . . cord-005453-4057qib7 8746 1 Median median JJ cord-005453-4057qib7 8746 2 nucleated nucleated JJ cord-005453-4057qib7 8746 3 cells cell NNS cord-005453-4057qib7 8746 4 of of IN cord-005453-4057qib7 8746 5 the the DT cord-005453-4057qib7 8746 6 cord cord NN cord-005453-4057qib7 8746 7 blood blood NN cord-005453-4057qib7 8746 8 were be VBD cord-005453-4057qib7 8746 9 14.23x10 14.23x10 CD cord-005453-4057qib7 8746 10 7 7 CD cord-005453-4057qib7 8747 1 /kg /kg . cord-005453-4057qib7 8748 1 ( ( -LRB- cord-005453-4057qib7 8748 2 range range NN cord-005453-4057qib7 8748 3 , , , cord-005453-4057qib7 8748 4 4.6 4.6 CD cord-005453-4057qib7 8748 5 to to TO cord-005453-4057qib7 8748 6 20.62 20.62 CD cord-005453-4057qib7 8748 7 x10 x10 CD cord-005453-4057qib7 8748 8 7 7 CD cord-005453-4057qib7 8748 9 /kg /kg . cord-005453-4057qib7 8748 10 ) ) -RRB- cord-005453-4057qib7 8748 11 , , , cord-005453-4057qib7 8748 12 and and CC cord-005453-4057qib7 8748 13 median median JJ cord-005453-4057qib7 8748 14 CD34 CD34 NNP cord-005453-4057qib7 8748 15 + + CC cord-005453-4057qib7 8748 16 cells cell NNS cord-005453-4057qib7 8748 17 were be VBD cord-005453-4057qib7 8748 18 3.87 3.87 CD cord-005453-4057qib7 8748 19 x10 x10 CD cord-005453-4057qib7 8748 20 5 5 CD cord-005453-4057qib7 8748 21 / / SYM cord-005453-4057qib7 8748 22 kg kg NN cord-005453-4057qib7 8748 23 ( ( -LRB- cord-005453-4057qib7 8748 24 range range NN cord-005453-4057qib7 8748 25 , , , cord-005453-4057qib7 8748 26 1.95 1.95 CD cord-005453-4057qib7 8748 27 to to TO cord-005453-4057qib7 8748 28 5.77 5.77 CD cord-005453-4057qib7 8748 29 x10 x10 CD cord-005453-4057qib7 8748 30 5 5 CD cord-005453-4057qib7 8749 1 /kg /kg LS cord-005453-4057qib7 8749 2 ) ) -RRB- cord-005453-4057qib7 8749 3 . . . cord-005453-4057qib7 8750 1 Results result NNS cord-005453-4057qib7 8750 2 : : : cord-005453-4057qib7 8751 1 All all DT cord-005453-4057qib7 8751 2 patients patient NNS cord-005453-4057qib7 8751 3 engrafted engraft VBD cord-005453-4057qib7 8751 4 , , , cord-005453-4057qib7 8751 5 median median JJ cord-005453-4057qib7 8751 6 time time NN cord-005453-4057qib7 8751 7 of of IN cord-005453-4057qib7 8751 8 neutrophil neutrophil NN cord-005453-4057qib7 8751 9 engraftment engraftment NN cord-005453-4057qib7 8751 10 was be VBD cord-005453-4057qib7 8751 11 24 24 CD cord-005453-4057qib7 8751 12 days day NNS cord-005453-4057qib7 8751 13 ( ( -LRB- cord-005453-4057qib7 8751 14 range range NN cord-005453-4057qib7 8751 15 , , , cord-005453-4057qib7 8751 16 13 13 CD cord-005453-4057qib7 8751 17 to to IN cord-005453-4057qib7 8751 18 28d 28d CD cord-005453-4057qib7 8751 19 ) ) -RRB- cord-005453-4057qib7 8751 20 , , , cord-005453-4057qib7 8751 21 and and CC cord-005453-4057qib7 8751 22 median median JJ cord-005453-4057qib7 8751 23 time time NN cord-005453-4057qib7 8751 24 of of IN cord-005453-4057qib7 8751 25 platelet platelet NN cord-005453-4057qib7 8751 26 engraftment engraftment NN cord-005453-4057qib7 8751 27 was be VBD cord-005453-4057qib7 8751 28 33 33 CD cord-005453-4057qib7 8751 29 days day NNS cord-005453-4057qib7 8751 30 ( ( -LRB- cord-005453-4057qib7 8751 31 range range NN cord-005453-4057qib7 8751 32 , , , cord-005453-4057qib7 8751 33 32 32 CD cord-005453-4057qib7 8751 34 to to IN cord-005453-4057qib7 8751 35 56d 56d CD cord-005453-4057qib7 8751 36 ) ) -RRB- cord-005453-4057qib7 8751 37 . . . cord-005453-4057qib7 8752 1 Median median JJ cord-005453-4057qib7 8752 2 follow follow NN cord-005453-4057qib7 8752 3 - - HYPH cord-005453-4057qib7 8752 4 up up RP cord-005453-4057qib7 8752 5 time time NN cord-005453-4057qib7 8752 6 was be VBD cord-005453-4057qib7 8752 7 13 13 CD cord-005453-4057qib7 8752 8 months month NNS cord-005453-4057qib7 8752 9 ( ( -LRB- cord-005453-4057qib7 8752 10 range range NN cord-005453-4057qib7 8752 11 , , , cord-005453-4057qib7 8752 12 2 2 CD cord-005453-4057qib7 8752 13 to to TO cord-005453-4057qib7 8752 14 25 25 CD cord-005453-4057qib7 8752 15 months month NNS cord-005453-4057qib7 8752 16 ) ) -RRB- cord-005453-4057qib7 8752 17 , , , cord-005453-4057qib7 8752 18 all all DT cord-005453-4057qib7 8752 19 5 5 CD cord-005453-4057qib7 8752 20 patients patient NNS cord-005453-4057qib7 8752 21 were be VBD cord-005453-4057qib7 8752 22 alive alive JJ cord-005453-4057qib7 8752 23 with with IN cord-005453-4057qib7 8752 24 continuous continuous JJ cord-005453-4057qib7 8752 25 completely completely RB cord-005453-4057qib7 8752 26 donor donor NN cord-005453-4057qib7 8752 27 engraftment engraftment NN cord-005453-4057qib7 8752 28 , , , cord-005453-4057qib7 8752 29 and and CC cord-005453-4057qib7 8752 30 achieved achieve VBN cord-005453-4057qib7 8752 31 complete complete JJ cord-005453-4057qib7 8752 32 clinical clinical JJ cord-005453-4057qib7 8752 33 remissions remission NNS cord-005453-4057qib7 8752 34 . . . cord-005453-4057qib7 8753 1 4/5 4/5 CD cord-005453-4057qib7 8753 2 patients patient NNS cord-005453-4057qib7 8753 3 developed develop VBD cord-005453-4057qib7 8753 4 grade grade NN cord-005453-4057qib7 8753 5 II II NNP cord-005453-4057qib7 8753 6 / / SYM cord-005453-4057qib7 8753 7 III iii CD cord-005453-4057qib7 8753 8 acute acute JJ cord-005453-4057qib7 8753 9 graft graft NN cord-005453-4057qib7 8753 10 - - HYPH cord-005453-4057qib7 8753 11 versus versus IN cord-005453-4057qib7 8753 12 - - HYPH cord-005453-4057qib7 8753 13 host host NN cord-005453-4057qib7 8753 14 disease disease NN cord-005453-4057qib7 8753 15 ( ( -LRB- cord-005453-4057qib7 8753 16 GVHD GVHD NNP cord-005453-4057qib7 8753 17 ) ) -RRB- cord-005453-4057qib7 8753 18 , , , cord-005453-4057qib7 8753 19 and and CC cord-005453-4057qib7 8753 20 1/5 1/5 CD cord-005453-4057qib7 8753 21 patients patient NNS cord-005453-4057qib7 8753 22 developed develop VBD cord-005453-4057qib7 8753 23 chronic chronic JJ cord-005453-4057qib7 8753 24 GVHD GVHD NNP cord-005453-4057qib7 8753 25 with with IN cord-005453-4057qib7 8753 26 skin skin NN cord-005453-4057qib7 8753 27 . . . cord-005453-4057qib7 8754 1 Conclusions conclusion NNS cord-005453-4057qib7 8754 2 : : : cord-005453-4057qib7 8755 1 It -PRON- PRP cord-005453-4057qib7 8755 2 is be VBZ cord-005453-4057qib7 8755 3 the the DT cord-005453-4057qib7 8755 4 first first JJ cord-005453-4057qib7 8755 5 successful successful JJ cord-005453-4057qib7 8755 6 unrelated unrelated JJ cord-005453-4057qib7 8755 7 UBCT UBCT NNP cord-005453-4057qib7 8755 8 for for IN cord-005453-4057qib7 8755 9 LAD lad NN cord-005453-4057qib7 8756 1 -I -i WDT cord-005453-4057qib7 8756 2 children child NNS cord-005453-4057qib7 8756 3 in in IN cord-005453-4057qib7 8756 4 China China NNP cord-005453-4057qib7 8756 5 . . . cord-005453-4057qib7 8757 1 Our -PRON- PRP$ cord-005453-4057qib7 8757 2 data datum NNS cord-005453-4057qib7 8757 3 shows show VBZ cord-005453-4057qib7 8757 4 UCBT UCBT NNP cord-005453-4057qib7 8757 5 provided provide VBD cord-005453-4057qib7 8757 6 excellent excellent JJ cord-005453-4057qib7 8757 7 outcome outcome NN cord-005453-4057qib7 8757 8 for for IN cord-005453-4057qib7 8757 9 patients patient NNS cord-005453-4057qib7 8757 10 with with IN cord-005453-4057qib7 8757 11 LAD LAD NNP cord-005453-4057qib7 8757 12 - - HYPH cord-005453-4057qib7 8757 13 I. I. NNP cord-005453-4057qib7 8757 14 Disclosure disclosure NN cord-005453-4057qib7 8757 15 : : : cord-005453-4057qib7 8757 16 Nothing nothing NN cord-005453-4057qib7 8757 17 to to TO cord-005453-4057qib7 8757 18 declare declare VB cord-005453-4057qib7 8757 19 P390 P390 NNP cord-005453-4057qib7 8757 20 Excellent excellent JJ cord-005453-4057qib7 8757 21 outcome outcome NN cord-005453-4057qib7 8757 22 using use VBG cord-005453-4057qib7 8757 23 ' ' `` cord-005453-4057qib7 8757 24 NKTM NKTM NNP cord-005453-4057qib7 8757 25 ' ' POS cord-005453-4057qib7 8757 26 enriched enrich VBN cord-005453-4057qib7 8757 27 hematopoietic hematopoietic JJ cord-005453-4057qib7 8757 28 stem stem NN cord-005453-4057qib7 8757 29 cell cell NN cord-005453-4057qib7 8757 30 transplants transplant NNS cord-005453-4057qib7 8757 31 for for IN cord-005453-4057qib7 8757 32 patients patient NNS cord-005453-4057qib7 8757 33 with with IN cord-005453-4057qib7 8757 34 inborn inborn JJ cord-005453-4057qib7 8757 35 errors error NNS cord-005453-4057qib7 8757 36 of of IN cord-005453-4057qib7 8757 37 immunity immunity NN cord-005453-4057qib7 8757 38 Results result NNS cord-005453-4057qib7 8757 39 : : : cord-005453-4057qib7 8757 40 Majority majority NN cord-005453-4057qib7 8757 41 of of IN cord-005453-4057qib7 8757 42 patients patient NNS cord-005453-4057qib7 8757 43 in in IN cord-005453-4057qib7 8757 44 the the DT cord-005453-4057qib7 8757 45 2 2 CD cord-005453-4057qib7 8757 46 cohorts cohort NNS cord-005453-4057qib7 8757 47 had have VBD cord-005453-4057qib7 8757 48 significant significant JJ cord-005453-4057qib7 8757 49 infective infective JJ cord-005453-4057qib7 8757 50 co co NNS cord-005453-4057qib7 8757 51 - - NNS cord-005453-4057qib7 8757 52 morbidities morbidity NNS cord-005453-4057qib7 8757 53 at at IN cord-005453-4057qib7 8757 54 the the DT cord-005453-4057qib7 8757 55 time time NN cord-005453-4057qib7 8757 56 of of IN cord-005453-4057qib7 8757 57 HSCT HSCT NNP cord-005453-4057qib7 8757 58 with with IN cord-005453-4057qib7 8757 59 patients patient NNS cord-005453-4057qib7 8757 60 in in IN cord-005453-4057qib7 8757 61 the the DT cord-005453-4057qib7 8757 62 later later JJ cord-005453-4057qib7 8757 63 cohort cohort NN cord-005453-4057qib7 8757 64 entering enter VBG cord-005453-4057qib7 8757 65 HSCT HSCT NNP cord-005453-4057qib7 8757 66 earlier early RBR cord-005453-4057qib7 8757 67 . . . cord-005453-4057qib7 8758 1 Patients patient NNS cord-005453-4057qib7 8758 2 in in IN cord-005453-4057qib7 8758 3 the the DT cord-005453-4057qib7 8758 4 later later JJ cord-005453-4057qib7 8758 5 cohort cohort NN cord-005453-4057qib7 8758 6 were be VBD cord-005453-4057qib7 8758 7 sicker sick JJR cord-005453-4057qib7 8758 8 at at IN cord-005453-4057qib7 8758 9 HSCT HSCT NNP cord-005453-4057qib7 8758 10 . . . cord-005453-4057qib7 8759 1 Final final JJ cord-005453-4057qib7 8759 2 engraftment engraftment NN cord-005453-4057qib7 8759 3 occurred occur VBD cord-005453-4057qib7 8759 4 in in IN cord-005453-4057qib7 8759 5 all all DT cord-005453-4057qib7 8759 6 except except IN cord-005453-4057qib7 8759 7 1 1 CD cord-005453-4057qib7 8759 8 patient patient NN cord-005453-4057qib7 8759 9 who who WP cord-005453-4057qib7 8759 10 received receive VBD cord-005453-4057qib7 8759 11 a a DT cord-005453-4057qib7 8759 12 HLA HLA NNP cord-005453-4057qib7 8759 13 mis mis NN cord-005453-4057qib7 8759 14 - - HYPH cord-005453-4057qib7 8759 15 matched match VBN cord-005453-4057qib7 8759 16 cord cord NN cord-005453-4057qib7 8759 17 blood blood NN cord-005453-4057qib7 8759 18 HSCT HSCT NNP cord-005453-4057qib7 8759 19 . . . cord-005453-4057qib7 8760 1 Graft graft NN cord-005453-4057qib7 8760 2 failures failure NNS cord-005453-4057qib7 8760 3 occurred occur VBD cord-005453-4057qib7 8760 4 in in IN cord-005453-4057qib7 8760 5 6 6 CD cord-005453-4057qib7 8760 6 patients patient NNS cord-005453-4057qib7 8760 7 ( ( -LRB- cord-005453-4057qib7 8760 8 2 2 CD cord-005453-4057qib7 8760 9 in in IN cord-005453-4057qib7 8760 10 earlier early JJR cord-005453-4057qib7 8760 11 and and CC cord-005453-4057qib7 8760 12 4 4 CD cord-005453-4057qib7 8760 13 in in IN cord-005453-4057qib7 8760 14 later later JJ cord-005453-4057qib7 8760 15 cohort cohort NN cord-005453-4057qib7 8760 16 ) ) -RRB- cord-005453-4057qib7 8760 17 ; ; : cord-005453-4057qib7 8760 18 3 3 CD cord-005453-4057qib7 8760 19 of of IN cord-005453-4057qib7 8760 20 these these DT cord-005453-4057qib7 8760 21 patients patient NNS cord-005453-4057qib7 8760 22 received receive VBD cord-005453-4057qib7 8760 23 unmanipulated unmanipulated JJ cord-005453-4057qib7 8760 24 HSCTs HSCTs NNPS cord-005453-4057qib7 8760 25 from from IN cord-005453-4057qib7 8760 26 HLA HLA NNP cord-005453-4057qib7 8760 27 mis mis NNP cord-005453-4057qib7 8760 28 - - HYPH cord-005453-4057qib7 8760 29 matched match VBN cord-005453-4057qib7 8760 30 unrelated unrelated JJ cord-005453-4057qib7 8760 31 donors donor NNS cord-005453-4057qib7 8760 32 ( ( -LRB- cord-005453-4057qib7 8760 33 1 1 CD cord-005453-4057qib7 8760 34 CB CB NNP cord-005453-4057qib7 8760 35 , , , cord-005453-4057qib7 8760 36 2 2 CD cord-005453-4057qib7 8760 37 BM BM NNP cord-005453-4057qib7 8760 38 ) ) -RRB- cord-005453-4057qib7 8760 39 . . . cord-005453-4057qib7 8761 1 Second second JJ cord-005453-4057qib7 8761 2 HSCT HSCT NNP cord-005453-4057qib7 8761 3 were be VBD cord-005453-4057qib7 8761 4 with with IN cord-005453-4057qib7 8761 5 same same JJ cord-005453-4057qib7 8761 6 donors donor NNS cord-005453-4057qib7 8761 7 in in IN cord-005453-4057qib7 8761 8 3 3 CD cord-005453-4057qib7 8761 9 and and CC cord-005453-4057qib7 8761 10 different different JJ cord-005453-4057qib7 8761 11 donors donor NNS cord-005453-4057qib7 8761 12 in in IN cord-005453-4057qib7 8761 13 2 2 CD cord-005453-4057qib7 8761 14 patients patient NNS cord-005453-4057qib7 8761 15 . . . cord-005453-4057qib7 8762 1 No no DT cord-005453-4057qib7 8762 2 grade grade NN cord-005453-4057qib7 8762 3 II II NNP cord-005453-4057qib7 8762 4 to to IN cord-005453-4057qib7 8762 5 IV IV NNP cord-005453-4057qib7 8762 6 acute acute JJ cord-005453-4057qib7 8762 7 GVHD GVHD NNP cord-005453-4057qib7 8762 8 or or CC cord-005453-4057qib7 8762 9 extensive extensive JJ cord-005453-4057qib7 8762 10 GVHD GVHD NNP cord-005453-4057qib7 8762 11 occurred occur VBD cord-005453-4057qib7 8762 12 . . . cord-005453-4057qib7 8763 1 One one CD cord-005453-4057qib7 8763 2 patient patient NN cord-005453-4057qib7 8763 3 ( ( -LRB- cord-005453-4057qib7 8763 4 CBT CBT NNP cord-005453-4057qib7 8763 5 ) ) -RRB- cord-005453-4057qib7 8763 6 died die VBD cord-005453-4057qib7 8763 7 of of IN cord-005453-4057qib7 8763 8 infections/ infections/ CD cord-005453-4057qib7 8763 9 non non JJ cord-005453-4057qib7 8763 10 - - JJ cord-005453-4057qib7 8763 11 engraftment engraftment JJ cord-005453-4057qib7 8763 12 . . . cord-005453-4057qib7 8764 1 All all DT cord-005453-4057qib7 8764 2 9 9 CD cord-005453-4057qib7 8764 3 patients patient NNS cord-005453-4057qib7 8764 4 in in IN cord-005453-4057qib7 8764 5 the the DT cord-005453-4057qib7 8764 6 later later JJ cord-005453-4057qib7 8764 7 cohort cohort NN cord-005453-4057qib7 8764 8 compared compare VBN cord-005453-4057qib7 8764 9 to to IN cord-005453-4057qib7 8764 10 7 7 CD cord-005453-4057qib7 8764 11 of of IN cord-005453-4057qib7 8764 12 9 9 CD cord-005453-4057qib7 8764 13 patients patient NNS cord-005453-4057qib7 8764 14 in in IN cord-005453-4057qib7 8764 15 earlier early JJR cord-005453-4057qib7 8764 16 cohort cohort NN cord-005453-4057qib7 8764 17 are be VBP cord-005453-4057qib7 8764 18 alive alive JJ cord-005453-4057qib7 8764 19 , , , cord-005453-4057qib7 8764 20 engrafted engraft VBN cord-005453-4057qib7 8764 21 and and CC cord-005453-4057qib7 8764 22 cured cure VBN cord-005453-4057qib7 8764 23 . . . cord-005453-4057qib7 8765 1 Performance performance NN cord-005453-4057qib7 8765 2 status status NN cord-005453-4057qib7 8765 3 were be VBD cord-005453-4057qib7 8765 4 100 100 CD cord-005453-4057qib7 8765 5 % % NN cord-005453-4057qib7 8765 6 in in IN cord-005453-4057qib7 8765 7 all all DT cord-005453-4057qib7 8765 8 alive alive JJ cord-005453-4057qib7 8765 9 patients patient NNS cord-005453-4057qib7 8765 10 . . . cord-005453-4057qib7 8766 1 Of of IN cord-005453-4057qib7 8766 2 the the DT cord-005453-4057qib7 8766 3 9 9 CD cord-005453-4057qib7 8766 4 patients patient NNS cord-005453-4057qib7 8766 5 in in IN cord-005453-4057qib7 8766 6 the the DT cord-005453-4057qib7 8766 7 later later JJ cord-005453-4057qib7 8766 8 cohort cohort NN cord-005453-4057qib7 8766 9 , , , cord-005453-4057qib7 8766 10 7 7 CD cord-005453-4057qib7 8766 11 ( ( -LRB- cord-005453-4057qib7 8766 12 6 6 CD cord-005453-4057qib7 8766 13 HLA HLA NNP cord-005453-4057qib7 8766 14 mis mis NN cord-005453-4057qib7 8766 15 - - HYPH cord-005453-4057qib7 8766 16 matched match VBN cord-005453-4057qib7 8766 17 related relate VBN cord-005453-4057qib7 8766 18 and and CC cord-005453-4057qib7 8766 19 1 1 CD cord-005453-4057qib7 8766 20 HLA HLA NNP cord-005453-4057qib7 8766 21 matched match VBN cord-005453-4057qib7 8766 22 related related JJ cord-005453-4057qib7 8766 23 donors donor NNS cord-005453-4057qib7 8766 24 ) ) -RRB- cord-005453-4057qib7 8766 25 received receive VBD cord-005453-4057qib7 8766 26 ' ' `` cord-005453-4057qib7 8766 27 NKTm nktm NN cord-005453-4057qib7 8766 28 ' ' POS cord-005453-4057qib7 8766 29 enriched enrich VBN cord-005453-4057qib7 8766 30 HSCT HSCT NNP cord-005453-4057qib7 8766 31 . . . cord-005453-4057qib7 8767 1 In in IN cord-005453-4057qib7 8767 2 the the DT cord-005453-4057qib7 8767 3 6 6 CD cord-005453-4057qib7 8767 4 HLA HLA NNP cord-005453-4057qib7 8767 5 mis mis NN cord-005453-4057qib7 8767 6 - - HYPH cord-005453-4057qib7 8767 7 matched match VBN cord-005453-4057qib7 8767 8 ' ' '' cord-005453-4057qib7 8767 9 NKTm nktm NN cord-005453-4057qib7 8767 10 ' ' POS cord-005453-4057qib7 8767 11 enriched enrich VBN cord-005453-4057qib7 8767 12 HSCTs hsct NNS cord-005453-4057qib7 8767 13 , , , cord-005453-4057qib7 8767 14 patients patient NNS cord-005453-4057qib7 8767 15 received receive VBD cord-005453-4057qib7 8767 16 high high JJ cord-005453-4057qib7 8767 17 CD34 CD34 NNP cord-005453-4057qib7 8767 18 + + CC cord-005453-4057qib7 8767 19 , , , cord-005453-4057qib7 8767 20 CD3+CD45RO+ cd3+cd45ro+ NN cord-005453-4057qib7 8767 21 and and CC cord-005453-4057qib7 8767 22 NK NK NNP cord-005453-4057qib7 8767 23 cell cell NN cord-005453-4057qib7 8767 24 doses dose NNS cord-005453-4057qib7 8767 25 , , , cord-005453-4057qib7 8767 26 with with IN cord-005453-4057qib7 8767 27 median median NN cord-005453-4057qib7 8767 28 of of IN cord-005453-4057qib7 8767 29 16.88 16.88 CD cord-005453-4057qib7 8767 30 ( ( -LRB- cord-005453-4057qib7 8767 31 range range NN cord-005453-4057qib7 8767 32 , , , cord-005453-4057qib7 8767 33 5.1 5.1 CD cord-005453-4057qib7 8767 34 -36.5 -36.5 NFP cord-005453-4057qib7 8767 35 ) ) -RRB- cord-005453-4057qib7 8767 36 , , , cord-005453-4057qib7 8767 37 113.9 113.9 CD cord-005453-4057qib7 8767 38 ( ( -LRB- cord-005453-4057qib7 8767 39 range range NN cord-005453-4057qib7 8767 40 , , , cord-005453-4057qib7 8767 41 3.3 3.3 CD cord-005453-4057qib7 8767 42 -232.6 -232.6 CD cord-005453-4057qib7 8767 43 ) ) -RRB- cord-005453-4057qib7 8767 44 and and CC cord-005453-4057qib7 8767 45 89.0 89.0 CD cord-005453-4057qib7 8767 46 ( ( -LRB- cord-005453-4057qib7 8767 47 range range NN cord-005453-4057qib7 8767 48 , , , cord-005453-4057qib7 8767 49 22 22 CD cord-005453-4057qib7 8767 50 -654 -654 NN cord-005453-4057qib7 8767 51 ) ) -RRB- cord-005453-4057qib7 8767 52 x10 x10 CD cord-005453-4057qib7 8767 53 6 6 CD cord-005453-4057qib7 8767 54 /kg /kg NN cord-005453-4057qib7 8767 55 , , , cord-005453-4057qib7 8767 56 respectively respectively RB cord-005453-4057qib7 8767 57 . . . cord-005453-4057qib7 8768 1 No no DT cord-005453-4057qib7 8768 2 invasive invasive JJ cord-005453-4057qib7 8768 3 infections infection NNS cord-005453-4057qib7 8768 4 occurred occur VBD cord-005453-4057qib7 8768 5 in in IN cord-005453-4057qib7 8768 6 these these DT cord-005453-4057qib7 8768 7 patients patient NNS cord-005453-4057qib7 8768 8 and and CC cord-005453-4057qib7 8768 9 immune immune JJ cord-005453-4057qib7 8768 10 reconstitution reconstitution NN cord-005453-4057qib7 8768 11 in in IN cord-005453-4057qib7 8768 12 T T NNP cord-005453-4057qib7 8768 13 , , , cord-005453-4057qib7 8768 14 B B NNP cord-005453-4057qib7 8768 15 , , , cord-005453-4057qib7 8768 16 NK NK NNP cord-005453-4057qib7 8768 17 compartments compartment NNS cord-005453-4057qib7 8768 18 were be VBD cord-005453-4057qib7 8768 19 complete complete JJ cord-005453-4057qib7 8768 20 at at IN cord-005453-4057qib7 8768 21 1 1 CD cord-005453-4057qib7 8768 22 year year NN cord-005453-4057qib7 8768 23 after after IN cord-005453-4057qib7 8768 24 HSCT HSCT NNP cord-005453-4057qib7 8768 25 with with IN cord-005453-4057qib7 8768 26 CD4 CD4 NNP cord-005453-4057qib7 8768 27 > > XX cord-005453-4057qib7 8768 28 200 200 CD cord-005453-4057qib7 8768 29 by by IN cord-005453-4057qib7 8768 30 6 6 CD cord-005453-4057qib7 8768 31 months month NNS cord-005453-4057qib7 8768 32 and and CC cord-005453-4057qib7 8769 1 TCRαb TCRαb NNP cord-005453-4057qib7 8769 2 > > XX cord-005453-4057qib7 8769 3 1500 1500 CD cord-005453-4057qib7 8769 4 by by IN cord-005453-4057qib7 8769 5 1 1 CD cord-005453-4057qib7 8769 6 year year NN cord-005453-4057qib7 8769 7 after after IN cord-005453-4057qib7 8769 8 HSCT HSCT NNP cord-005453-4057qib7 8769 9 . . . cord-005453-4057qib7 8770 1 Background background NN cord-005453-4057qib7 8770 2 : : : cord-005453-4057qib7 8771 1 Viral viral JJ cord-005453-4057qib7 8771 2 infections infection NNS cord-005453-4057qib7 8771 3 contribute contribute VBP cord-005453-4057qib7 8771 4 to to IN cord-005453-4057qib7 8771 5 significant significant JJ cord-005453-4057qib7 8771 6 morbidity morbidity NN cord-005453-4057qib7 8771 7 and and CC cord-005453-4057qib7 8771 8 mortality mortality NN cord-005453-4057qib7 8771 9 after after IN cord-005453-4057qib7 8771 10 allogeneic allogeneic JJ cord-005453-4057qib7 8771 11 hematopoietic hematopoietic JJ cord-005453-4057qib7 8771 12 cell cell NN cord-005453-4057qib7 8771 13 transplantation transplantation NN cord-005453-4057qib7 8771 14 ( ( -LRB- cord-005453-4057qib7 8771 15 allo allo NN cord-005453-4057qib7 8771 16 - - HYPH cord-005453-4057qib7 8771 17 HSCT HSCT NNP cord-005453-4057qib7 8771 18 ) ) -RRB- cord-005453-4057qib7 8771 19 , , , cord-005453-4057qib7 8771 20 increasing increase VBG cord-005453-4057qib7 8771 21 both both CC cord-005453-4057qib7 8771 22 the the DT cord-005453-4057qib7 8771 23 human human NN cord-005453-4057qib7 8771 24 and and CC cord-005453-4057qib7 8771 25 the the DT cord-005453-4057qib7 8771 26 financial financial JJ cord-005453-4057qib7 8771 27 cost cost NN cord-005453-4057qib7 8771 28 . . . cord-005453-4057qib7 8772 1 Antiviral antiviral JJ cord-005453-4057qib7 8772 2 agents agent NNS cord-005453-4057qib7 8772 3 are be VBP cord-005453-4057qib7 8772 4 often often RB cord-005453-4057qib7 8772 5 ineffective ineffective JJ cord-005453-4057qib7 8772 6 or/ or/ NN cord-005453-4057qib7 8772 7 and and CC cord-005453-4057qib7 8772 8 associated associate VBN cord-005453-4057qib7 8772 9 with with IN cord-005453-4057qib7 8772 10 toxicity toxicity NN cord-005453-4057qib7 8772 11 . . . cord-005453-4057qib7 8773 1 Methods method NNS cord-005453-4057qib7 8773 2 : : : cord-005453-4057qib7 8774 1 In in IN cord-005453-4057qib7 8774 2 view view NN cord-005453-4057qib7 8774 3 of of IN cord-005453-4057qib7 8774 4 T t NN cord-005453-4057qib7 8774 5 - - HYPH cord-005453-4057qib7 8774 6 cell cell NN cord-005453-4057qib7 8774 7 anti anti JJ cord-005453-4057qib7 8774 8 - - JJ cord-005453-4057qib7 8774 9 viral viral JJ cord-005453-4057qib7 8774 10 immunotherapy immunotherapy NN cord-005453-4057qib7 8774 11 in in IN cord-005453-4057qib7 8774 12 Greece Greece NNP cord-005453-4057qib7 8774 13 , , , cord-005453-4057qib7 8774 14 we -PRON- PRP cord-005453-4057qib7 8774 15 evaluated evaluate VBD cord-005453-4057qib7 8774 16 the the DT cord-005453-4057qib7 8774 17 actual actual JJ cord-005453-4057qib7 8774 18 cost cost NN cord-005453-4057qib7 8774 19 of of IN cord-005453-4057qib7 8774 20 conventional conventional JJ cord-005453-4057qib7 8774 21 pharmacotherapy pharmacotherapy NN cord-005453-4057qib7 8774 22 for for IN cord-005453-4057qib7 8774 23 CMV CMV NNP cord-005453-4057qib7 8774 24 , , , cord-005453-4057qib7 8774 25 EBV EBV NNP cord-005453-4057qib7 8774 26 and and CC cord-005453-4057qib7 8774 27 BKV BKV NNP cord-005453-4057qib7 8774 28 reactivations reactivation NNS cord-005453-4057qib7 8774 29 after after IN cord-005453-4057qib7 8774 30 allo allo NN cord-005453-4057qib7 8774 31 - - HYPH cord-005453-4057qib7 8774 32 HSCT HSCT NNP cord-005453-4057qib7 8774 33 , , , cord-005453-4057qib7 8774 34 by by IN cord-005453-4057qib7 8774 35 calculating calculate VBG cord-005453-4057qib7 8774 36 the the DT cord-005453-4057qib7 8774 37 costs cost NNS cord-005453-4057qib7 8774 38 of of IN cord-005453-4057qib7 8774 39 ( ( -LRB- cord-005453-4057qib7 8774 40 i i NN cord-005453-4057qib7 8774 41 ) ) -RRB- cord-005453-4057qib7 8774 42 the the DT cord-005453-4057qib7 8774 43 antiviral antiviral JJ cord-005453-4057qib7 8774 44 agents agent NNS cord-005453-4057qib7 8774 45 , , , cord-005453-4057qib7 8774 46 ( ( -LRB- cord-005453-4057qib7 8774 47 ii ii NN cord-005453-4057qib7 8774 48 ) ) -RRB- cord-005453-4057qib7 8775 1 the the DT cord-005453-4057qib7 8775 2 treatment treatment NN cord-005453-4057qib7 8775 3 ( ( -LRB- cord-005453-4057qib7 8775 4 excluding exclude VBG cord-005453-4057qib7 8775 5 transfusions transfusion NNS cord-005453-4057qib7 8775 6 ) ) -RRB- cord-005453-4057qib7 8775 7 of of IN cord-005453-4057qib7 8775 8 antiviral antiviral JJ cord-005453-4057qib7 8775 9 drug drug NN cord-005453-4057qib7 8775 10 primary primary JJ cord-005453-4057qib7 8775 11 toxicity toxicity NN cord-005453-4057qib7 8775 12 ( ( -LRB- cord-005453-4057qib7 8775 13 e.g. e.g. IN cord-005453-4057qib7 8775 14 graft graft NN cord-005453-4057qib7 8775 15 failure failure NN cord-005453-4057qib7 8775 16 , , , cord-005453-4057qib7 8775 17 cytopenias cytopenia NNS cord-005453-4057qib7 8775 18 , , , cord-005453-4057qib7 8775 19 renal renal JJ cord-005453-4057qib7 8775 20 or or CC cord-005453-4057qib7 8775 21 hepatic hepatic JJ cord-005453-4057qib7 8775 22 dysfunction dysfunction NN cord-005453-4057qib7 8775 23 ) ) -RRB- cord-005453-4057qib7 8775 24 and and CC cord-005453-4057qib7 8775 25 secondary secondary JJ cord-005453-4057qib7 8775 26 toxicity toxicity NN cord-005453-4057qib7 8775 27 ( ( -LRB- cord-005453-4057qib7 8775 28 e.g. e.g. IN cord-005453-4057qib7 8775 29 leukopenia leukopenia NN cord-005453-4057qib7 8775 30 - - HYPH cord-005453-4057qib7 8775 31 associated associate VBN cord-005453-4057qib7 8775 32 bacterial bacterial JJ cord-005453-4057qib7 8775 33 infections infection NNS cord-005453-4057qib7 8775 34 ) ) -RRB- cord-005453-4057qib7 8775 35 , , , cord-005453-4057qib7 8775 36 iii iii NN cord-005453-4057qib7 8775 37 ) ) -RRB- cord-005453-4057qib7 8776 1 the the DT cord-005453-4057qib7 8776 2 treatment treatment NN cord-005453-4057qib7 8776 3 ( ( -LRB- cord-005453-4057qib7 8776 4 excluding exclude VBG cord-005453-4057qib7 8776 5 transfusions transfusion NNS cord-005453-4057qib7 8776 6 , , , cord-005453-4057qib7 8776 7 ie ie FW cord-005453-4057qib7 8776 8 for for IN cord-005453-4057qib7 8776 9 BK BK NNP cord-005453-4057qib7 8776 10 cystitis cystitis NNP cord-005453-4057qib7 8776 11 ) ) -RRB- cord-005453-4057qib7 8776 12 of of IN cord-005453-4057qib7 8776 13 infectionrelated infectionrelate VBN cord-005453-4057qib7 8776 14 complications complication NNS cord-005453-4057qib7 8776 15 , , , cord-005453-4057qib7 8776 16 iv iv LS cord-005453-4057qib7 8776 17 ) ) -RRB- cord-005453-4057qib7 8777 1 the the DT cord-005453-4057qib7 8777 2 transfusions transfusion NNS cord-005453-4057qib7 8777 3 due due JJ cord-005453-4057qib7 8777 4 to to IN cord-005453-4057qib7 8777 5 treatmentrelated treatmentrelate VBN cord-005453-4057qib7 8777 6 toxicity toxicity NN cord-005453-4057qib7 8777 7 ( ( -LRB- cord-005453-4057qib7 8777 8 ie ie NNP cord-005453-4057qib7 8777 9 cytopenias cytopenias NNP cord-005453-4057qib7 8777 10 ) ) -RRB- cord-005453-4057qib7 8777 11 or or CC cord-005453-4057qib7 8777 12 infection infection NN cord-005453-4057qib7 8777 13 - - HYPH cord-005453-4057qib7 8777 14 related relate VBN cord-005453-4057qib7 8777 15 complications complication NNS cord-005453-4057qib7 8777 16 ( ( -LRB- cord-005453-4057qib7 8777 17 ie ie FW cord-005453-4057qib7 8777 18 , , , cord-005453-4057qib7 8777 19 BK BK NNP cord-005453-4057qib7 8777 20 cystitis cystitis NNP cord-005453-4057qib7 8777 21 ) ) -RRB- cord-005453-4057qib7 8777 22 , , , cord-005453-4057qib7 8777 23 v v LS cord-005453-4057qib7 8777 24 ) ) -RRB- cord-005453-4057qib7 8777 25 the the DT cord-005453-4057qib7 8777 26 inpatient inpatient JJ cord-005453-4057qib7 8777 27 or or CC cord-005453-4057qib7 8777 28 outpatient outpatient JJ cord-005453-4057qib7 8777 29 daily daily JJ cord-005453-4057qib7 8777 30 care care NN cord-005453-4057qib7 8777 31 . . . cord-005453-4057qib7 8778 1 Notwithstanding notwithstanding IN cord-005453-4057qib7 8778 2 that that DT cord-005453-4057qib7 8778 3 blood blood NN cord-005453-4057qib7 8778 4 and and CC cord-005453-4057qib7 8778 5 its -PRON- PRP$ cord-005453-4057qib7 8778 6 products product NNS cord-005453-4057qib7 8778 7 , , , cord-005453-4057qib7 8778 8 as as IN cord-005453-4057qib7 8778 9 a a DT cord-005453-4057qib7 8778 10 common common JJ cord-005453-4057qib7 8778 11 natural natural JJ cord-005453-4057qib7 8778 12 good good NN cord-005453-4057qib7 8778 13 , , , cord-005453-4057qib7 8778 14 are be VBP cord-005453-4057qib7 8778 15 provided provide VBN cord-005453-4057qib7 8778 16 free free JJ cord-005453-4057qib7 8778 17 in in IN cord-005453-4057qib7 8778 18 our -PRON- PRP$ cord-005453-4057qib7 8778 19 country country NN cord-005453-4057qib7 8778 20 , , , cord-005453-4057qib7 8778 21 the the DT cord-005453-4057qib7 8778 22 costs cost NNS cord-005453-4057qib7 8778 23 related relate VBN cord-005453-4057qib7 8778 24 to to IN cord-005453-4057qib7 8778 25 blood blood NN cord-005453-4057qib7 8778 26 and and CC cord-005453-4057qib7 8778 27 platelet platelet NN cord-005453-4057qib7 8778 28 collection collection NN cord-005453-4057qib7 8778 29 , , , cord-005453-4057qib7 8778 30 processing processing NN cord-005453-4057qib7 8778 31 , , , cord-005453-4057qib7 8778 32 storage storage NN cord-005453-4057qib7 8778 33 , , , cord-005453-4057qib7 8778 34 laboratory laboratory NN cord-005453-4057qib7 8778 35 testing testing NN cord-005453-4057qib7 8778 36 and and CC cord-005453-4057qib7 8778 37 infusions infusion NNS cord-005453-4057qib7 8778 38 were be VBD cord-005453-4057qib7 8778 39 included include VBN cord-005453-4057qib7 8778 40 in in IN cord-005453-4057qib7 8778 41 our -PRON- PRP$ cord-005453-4057qib7 8778 42 model model NN cord-005453-4057qib7 8778 43 . . . cord-005453-4057qib7 8779 1 Results result NNS cord-005453-4057qib7 8779 2 : : : cord-005453-4057qib7 8780 1 The the DT cord-005453-4057qib7 8780 2 treatment treatment NN cord-005453-4057qib7 8780 3 cost cost NN cord-005453-4057qib7 8780 4 of of IN cord-005453-4057qib7 8780 5 CMV CMV NNP cord-005453-4057qib7 8780 6 , , , cord-005453-4057qib7 8780 7 EBV EBV NNP cord-005453-4057qib7 8780 8 and and CC cord-005453-4057qib7 8780 9 BKV BKV NNP cord-005453-4057qib7 8780 10 reactivations reactivation NNS cord-005453-4057qib7 8780 11 / / SYM cord-005453-4057qib7 8780 12 infections infection NNS cord-005453-4057qib7 8780 13 for for IN cord-005453-4057qib7 8780 14 the the DT cord-005453-4057qib7 8780 15 first first JJ cord-005453-4057qib7 8780 16 six six CD cord-005453-4057qib7 8780 17 months month NNS cord-005453-4057qib7 8780 18 post post VBP cord-005453-4057qib7 8780 19 allo allo NN cord-005453-4057qib7 8780 20 - - HYPH cord-005453-4057qib7 8780 21 HSCT HSCT NNP cord-005453-4057qib7 8780 22 was be VBD cord-005453-4057qib7 8780 23 evaluated evaluate VBN cord-005453-4057qib7 8780 24 in in IN cord-005453-4057qib7 8780 25 38/51 38/51 CD cord-005453-4057qib7 8780 26 patients patient NNS cord-005453-4057qib7 8780 27 who who WP cord-005453-4057qib7 8780 28 reactivated reactivate VBD cord-005453-4057qib7 8780 29 viruses virus NNS cord-005453-4057qib7 8780 30 and and CC cord-005453-4057qib7 8780 31 were be VBD cord-005453-4057qib7 8780 32 transplanted transplant VBN cord-005453-4057qib7 8780 33 between between IN cord-005453-4057qib7 8780 34 10/2015 10/2015 CD cord-005453-4057qib7 8780 35 - - SYM cord-005453-4057qib7 8780 36 11/2016 11/2016 CD cord-005453-4057qib7 8780 37 from from IN cord-005453-4057qib7 8780 38 matched match VBN cord-005453-4057qib7 8780 39 related relate VBN cord-005453-4057qib7 8780 40 ( ( -LRB- cord-005453-4057qib7 8780 41 17/51 17/51 CD cord-005453-4057qib7 8780 42 ) ) -RRB- cord-005453-4057qib7 8780 43 , , , cord-005453-4057qib7 8780 44 matched match VBN cord-005453-4057qib7 8780 45 unrelated unrelated JJ cord-005453-4057qib7 8780 46 ( ( -LRB- cord-005453-4057qib7 8780 47 20/51 20/51 CD cord-005453-4057qib7 8780 48 ) ) -RRB- cord-005453-4057qib7 8780 49 , , , cord-005453-4057qib7 8780 50 mismatched mismatch VBN cord-005453-4057qib7 8780 51 unrelated unrelated JJ cord-005453-4057qib7 8780 52 ( ( -LRB- cord-005453-4057qib7 8780 53 8/51 8/51 CD cord-005453-4057qib7 8780 54 ) ) -RRB- cord-005453-4057qib7 8780 55 , , , cord-005453-4057qib7 8780 56 haploidentical haploidentical NNP cord-005453-4057qib7 8780 57 ( ( -LRB- cord-005453-4057qib7 8780 58 5/51 5/51 CD cord-005453-4057qib7 8780 59 ) ) -RRB- cord-005453-4057qib7 8780 60 and and CC cord-005453-4057qib7 8780 61 mismatched mismatch VBD cord-005453-4057qib7 8780 62 related related JJ cord-005453-4057qib7 8780 63 donors donor NNS cord-005453-4057qib7 8780 64 ( ( -LRB- cord-005453-4057qib7 8780 65 1/51 1/51 CD cord-005453-4057qib7 8780 66 ) ) -RRB- cord-005453-4057qib7 8780 67 . . . cord-005453-4057qib7 8781 1 We -PRON- PRP cord-005453-4057qib7 8781 2 detected detect VBD cord-005453-4057qib7 8781 3 29 29 CD cord-005453-4057qib7 8781 4 CMV CMV NNP cord-005453-4057qib7 8781 5 , , , cord-005453-4057qib7 8781 6 35 35 CD cord-005453-4057qib7 8781 7 EBV EBV NNP cord-005453-4057qib7 8781 8 and and CC cord-005453-4057qib7 8781 9 18 18 CD cord-005453-4057qib7 8781 10 BKV BKV NNP cord-005453-4057qib7 8781 11 infections infection NNS cord-005453-4057qib7 8781 12 / / SYM cord-005453-4057qib7 8781 13 reactivations reactivation NNS cord-005453-4057qib7 8781 14 in in IN cord-005453-4057qib7 8781 15 20 20 CD cord-005453-4057qib7 8781 16 , , , cord-005453-4057qib7 8781 17 32 32 CD cord-005453-4057qib7 8781 18 and and CC cord-005453-4057qib7 8781 19 17 17 CD cord-005453-4057qib7 8781 20 patients patient NNS cord-005453-4057qib7 8781 21 respectively respectively RB cord-005453-4057qib7 8781 22 , , , cord-005453-4057qib7 8781 23 with with IN cord-005453-4057qib7 8781 24 a a DT cord-005453-4057qib7 8781 25 mean mean NN cord-005453-4057qib7 8781 26 of of IN cord-005453-4057qib7 8781 27 2±0.4 2±0.4 CD cord-005453-4057qib7 8781 28 infection infection NN cord-005453-4057qib7 8781 29 per per IN cord-005453-4057qib7 8781 30 patient patient NN cord-005453-4057qib7 8781 31 from from IN cord-005453-4057qib7 8781 32 all all DT cord-005453-4057qib7 8781 33 three three CD cord-005453-4057qib7 8781 34 viruses virus NNS cord-005453-4057qib7 8781 35 ( ( -LRB- cord-005453-4057qib7 8781 36 1 1 CD cord-005453-4057qib7 8781 37 - - SYM cord-005453-4057qib7 8781 38 7 7 CD cord-005453-4057qib7 8781 39 / / SYM cord-005453-4057qib7 8781 40 patient patient NN cord-005453-4057qib7 8781 41 ) ) -RRB- cord-005453-4057qib7 8781 42 . . . cord-005453-4057qib7 8782 1 Of of IN cord-005453-4057qib7 8782 2 note note NN cord-005453-4057qib7 8782 3 , , , cord-005453-4057qib7 8782 4 22/38 22/38 CD cord-005453-4057qib7 8782 5 patients patient NNS cord-005453-4057qib7 8782 6 experienced experience VBD cord-005453-4057qib7 8782 7 reactivations reactivation NNS cord-005453-4057qib7 8782 8 from from IN cord-005453-4057qib7 8782 9 more more JJR cord-005453-4057qib7 8782 10 than than IN cord-005453-4057qib7 8782 11 one one CD cord-005453-4057qib7 8782 12 virus virus NN cord-005453-4057qib7 8782 13 , , , cord-005453-4057qib7 8782 14 requiring require VBG cord-005453-4057qib7 8782 15 repeated repeat VBN cord-005453-4057qib7 8782 16 treatments treatment NNS cord-005453-4057qib7 8782 17 with with IN cord-005453-4057qib7 8782 18 antiviral antiviral JJ cord-005453-4057qib7 8782 19 agents agent NNS cord-005453-4057qib7 8782 20 and/or and/or CC cord-005453-4057qib7 8782 21 rituximab rituximab NN cord-005453-4057qib7 8782 22 . . . cord-005453-4057qib7 8783 1 The the DT cord-005453-4057qib7 8783 2 cost cost NN cord-005453-4057qib7 8783 3 of of IN cord-005453-4057qib7 8783 4 antiviral antiviral JJ cord-005453-4057qib7 8783 5 agents agent NNS cord-005453-4057qib7 8783 6 for for IN cord-005453-4057qib7 8783 7 all all DT cord-005453-4057qib7 8783 8 CMV CMV NNP cord-005453-4057qib7 8783 9 , , , cord-005453-4057qib7 8783 10 EBV EBV NNP cord-005453-4057qib7 8783 11 and and CC cord-005453-4057qib7 8783 12 BKV BKV NNP cord-005453-4057qib7 8783 13 reactivations reactivation NNS cord-005453-4057qib7 8783 14 / / SYM cord-005453-4057qib7 8783 15 infections infection NNS cord-005453-4057qib7 8783 16 was be VBD cord-005453-4057qib7 8783 17 78,656 78,656 CD cord-005453-4057qib7 8783 18 € € $ cord-005453-4057qib7 8783 19 , , , cord-005453-4057qib7 8783 20 58,504 58,504 CD cord-005453-4057qib7 8783 21 € € SYM cord-005453-4057qib7 8783 22 and and CC cord-005453-4057qib7 8783 23 11,331 11,331 CD cord-005453-4057qib7 8784 1 € € $ cord-005453-4057qib7 8784 2 respectively respectively RB cord-005453-4057qib7 8784 3 ( ( -LRB- cord-005453-4057qib7 8784 4 3,146 3,146 CD cord-005453-4057qib7 8784 5 € € $ cord-005453-4057qib7 8784 6 , , , cord-005453-4057qib7 8784 7 2,089 2,089 CD cord-005453-4057qib7 8784 8 € € SYM cord-005453-4057qib7 8784 9 and and CC cord-005453-4057qib7 8784 10 1,416 1,416 CD cord-005453-4057qib7 8784 11 € € CD cord-005453-4057qib7 8784 12 /patient /patient NN cord-005453-4057qib7 8784 13 , , , cord-005453-4057qib7 8784 14 respectively respectively RB cord-005453-4057qib7 8784 15 ) ) -RRB- cord-005453-4057qib7 8784 16 . . . cord-005453-4057qib7 8785 1 The the DT cord-005453-4057qib7 8785 2 treatment treatment NN cord-005453-4057qib7 8785 3 cost cost NN cord-005453-4057qib7 8785 4 of of IN cord-005453-4057qib7 8785 5 toxicity toxicity NN cord-005453-4057qib7 8785 6 related relate VBN cord-005453-4057qib7 8785 7 to to IN cord-005453-4057qib7 8785 8 antiviral antiviral JJ cord-005453-4057qib7 8785 9 drugs drug NNS cord-005453-4057qib7 8785 10 and and CC cord-005453-4057qib7 8785 11 infection infection NN cord-005453-4057qib7 8785 12 - - HYPH cord-005453-4057qib7 8785 13 related relate VBN cord-005453-4057qib7 8785 14 complications complication NNS cord-005453-4057qib7 8785 15 was be VBD cord-005453-4057qib7 8785 16 70,358 70,358 CD cord-005453-4057qib7 8785 17 € € $ cord-005453-4057qib7 8785 18 ( ( -LRB- cord-005453-4057qib7 8785 19 4,309€/patient 4,309€/patient CD cord-005453-4057qib7 8785 20 ) ) -RRB- cord-005453-4057qib7 8785 21 excluding exclude VBG cord-005453-4057qib7 8785 22 transfusions transfusion NNS cord-005453-4057qib7 8785 23 and and CC cord-005453-4057qib7 8785 24 676,107 676,107 CD cord-005453-4057qib7 8785 25 € € XX cord-005453-4057qib7 8785 26 ( ( -LRB- cord-005453-4057qib7 8785 27 28,171€/patient 28,171€/patient CD cord-005453-4057qib7 8785 28 ) ) -RRB- cord-005453-4057qib7 8785 29 including include VBG cord-005453-4057qib7 8785 30 transfusions transfusion NNS cord-005453-4057qib7 8785 31 . . . cord-005453-4057qib7 8786 1 In in IN cord-005453-4057qib7 8786 2 particular particular JJ cord-005453-4057qib7 8786 3 , , , cord-005453-4057qib7 8786 4 the the DT cord-005453-4057qib7 8786 5 cost cost NN cord-005453-4057qib7 8786 6 of of IN cord-005453-4057qib7 8786 7 transfusions transfusion NNS cord-005453-4057qib7 8786 8 for for IN cord-005453-4057qib7 8786 9 BKV bkv JJ cord-005453-4057qib7 8786 10 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 8786 11 cystitis cystitis NN cord-005453-4057qib7 8786 12 reached reach VBD cord-005453-4057qib7 8786 13 22,751€/patient 22,751€/patient CD cord-005453-4057qib7 8786 14 . . . cord-005453-4057qib7 8787 1 Repeated repeat VBN cord-005453-4057qib7 8787 2 ( ( -LRB- cord-005453-4057qib7 8787 3 1 1 CD cord-005453-4057qib7 8787 4 - - SYM cord-005453-4057qib7 8787 5 5 5 CD cord-005453-4057qib7 8787 6 ) ) -RRB- cord-005453-4057qib7 8788 1 and/or and/or CC cord-005453-4057qib7 8788 2 prolonged prolonged JJ cord-005453-4057qib7 8788 3 ( ( -LRB- cord-005453-4057qib7 8788 4 Δm Δm NNP cord-005453-4057qib7 8788 5 38d 38d NNS cord-005453-4057qib7 8788 6 , , , cord-005453-4057qib7 8788 7 range range NNP cord-005453-4057qib7 8788 8 6 6 CD cord-005453-4057qib7 8788 9 - - HYPH cord-005453-4057qib7 8788 10 150d 150d NNP cord-005453-4057qib7 8788 11 ) ) -RRB- cord-005453-4057qib7 8788 12 hospitalizations hospitalization NNS cord-005453-4057qib7 8788 13 were be VBD cord-005453-4057qib7 8788 14 needed need VBN cord-005453-4057qib7 8788 15 , , , cord-005453-4057qib7 8788 16 up up IN cord-005453-4057qib7 8788 17 to to IN cord-005453-4057qib7 8788 18 a a DT cord-005453-4057qib7 8788 19 total total NN cord-005453-4057qib7 8788 20 of of IN cord-005453-4057qib7 8788 21 745 745 CD cord-005453-4057qib7 8788 22 and and CC cord-005453-4057qib7 8788 23 159 159 CD cord-005453-4057qib7 8788 24 days day NNS cord-005453-4057qib7 8788 25 of of IN cord-005453-4057qib7 8788 26 inpatient inpatient JJ cord-005453-4057qib7 8788 27 hospitalization hospitalization NN cord-005453-4057qib7 8788 28 and and CC cord-005453-4057qib7 8788 29 short short JJ cord-005453-4057qib7 8788 30 - - HYPH cord-005453-4057qib7 8788 31 term term NN cord-005453-4057qib7 8788 32 outpatient outpatient NN cord-005453-4057qib7 8788 33 treatment treatment NN cord-005453-4057qib7 8788 34 , , , cord-005453-4057qib7 8788 35 respectively respectively RB cord-005453-4057qib7 8788 36 . . . cord-005453-4057qib7 8789 1 Hospitalizations hospitalization NNS cord-005453-4057qib7 8789 2 further further RB cord-005453-4057qib7 8789 3 increased increase VBD cord-005453-4057qib7 8789 4 the the DT cord-005453-4057qib7 8789 5 cost cost NN cord-005453-4057qib7 8789 6 of of IN cord-005453-4057qib7 8789 7 inpatient inpatient JJ cord-005453-4057qib7 8789 8 and and CC cord-005453-4057qib7 8789 9 outpatient outpatient JJ cord-005453-4057qib7 8789 10 post post JJ cord-005453-4057qib7 8789 11 - - JJ cord-005453-4057qib7 8789 12 transplant transplant JJ cord-005453-4057qib7 8789 13 care care NN cord-005453-4057qib7 8789 14 by by IN cord-005453-4057qib7 8789 15 81,640 81,640 CD cord-005453-4057qib7 8789 16 € € SYM cord-005453-4057qib7 8789 17 and and CC cord-005453-4057qib7 8789 18 8,000 8,000 CD cord-005453-4057qib7 8789 19 € € $ cord-005453-4057qib7 8789 20 respectively respectively RB cord-005453-4057qib7 8789 21 ( ( -LRB- cord-005453-4057qib7 8789 22 2,634 2,634 CD cord-005453-4057qib7 8789 23 € € SYM cord-005453-4057qib7 8789 24 and and CC cord-005453-4057qib7 8789 25 500€/patient 500€/patient CD cord-005453-4057qib7 8789 26 , , , cord-005453-4057qib7 8789 27 respectively respectively RB cord-005453-4057qib7 8789 28 ) ) -RRB- cord-005453-4057qib7 8789 29 , , , cord-005453-4057qib7 8789 30 onthe onthe JJ cord-005453-4057qib7 8789 31 basis basis NN cord-005453-4057qib7 8789 32 of of IN cord-005453-4057qib7 8789 33 a a DT cord-005453-4057qib7 8789 34 , , , cord-005453-4057qib7 8789 35 rather rather RB cord-005453-4057qib7 8789 36 underestimating underestimate VBG cord-005453-4057qib7 8789 37 the the DT cord-005453-4057qib7 8789 38 true true JJ cord-005453-4057qib7 8789 39 cost cost NN cord-005453-4057qib7 8789 40 , , , cord-005453-4057qib7 8789 41 fixed fix VBN cord-005453-4057qib7 8789 42 , , , cord-005453-4057qib7 8789 43 unified unified JJ cord-005453-4057qib7 8789 44 hospitalization hospitalization NN cord-005453-4057qib7 8789 45 fee fee NN cord-005453-4057qib7 8789 46 ( ( -LRB- cord-005453-4057qib7 8790 1 60€/day 60€/day CD cord-005453-4057qib7 8790 2 and and CC cord-005453-4057qib7 8790 3 200 200 CD cord-005453-4057qib7 8790 4 € € CD cord-005453-4057qib7 8790 5 /day /day CD cord-005453-4057qib7 8790 6 ) ) -RRB- cord-005453-4057qib7 8790 7 . . . cord-005453-4057qib7 8791 1 Conclusions conclusion NNS cord-005453-4057qib7 8791 2 : : : cord-005453-4057qib7 8792 1 Overall overall RB cord-005453-4057qib7 8792 2 , , , cord-005453-4057qib7 8792 3 in in IN cord-005453-4057qib7 8792 4 a a DT cord-005453-4057qib7 8792 5 six six CD cord-005453-4057qib7 8792 6 - - HYPH cord-005453-4057qib7 8792 7 month month NN cord-005453-4057qib7 8792 8 study study NN cord-005453-4057qib7 8792 9 period period NN cord-005453-4057qib7 8792 10 , , , cord-005453-4057qib7 8792 11 the the DT cord-005453-4057qib7 8792 12 treatment treatment NN cord-005453-4057qib7 8792 13 of of IN cord-005453-4057qib7 8792 14 CMV CMV NNP cord-005453-4057qib7 8792 15 , , , cord-005453-4057qib7 8792 16 EBV EBV NNP cord-005453-4057qib7 8792 17 and and CC cord-005453-4057qib7 8792 18 BKV BKV NNP cord-005453-4057qib7 8792 19 infections infection NNS cord-005453-4057qib7 8792 20 substantially substantially RB cord-005453-4057qib7 8792 21 increased increase VBD cord-005453-4057qib7 8792 22 the the DT cord-005453-4057qib7 8792 23 cost cost NN cord-005453-4057qib7 8792 24 of of IN cord-005453-4057qib7 8792 25 post post JJ cord-005453-4057qib7 8792 26 - - JJ cord-005453-4057qib7 8792 27 transplant transplant JJ cord-005453-4057qib7 8792 28 care care NN cord-005453-4057qib7 8792 29 by by IN cord-005453-4057qib7 8792 30 956,283 956,283 CD cord-005453-4057qib7 8792 31 € € NNPS cord-005453-4057qib7 8792 32 ( ( -LRB- cord-005453-4057qib7 8792 33 27,322€/patient 27,322€/patient NNP cord-005453-4057qib7 8792 34 ) ) -RRB- cord-005453-4057qib7 8792 35 . . . cord-005453-4057qib7 8793 1 The the DT cord-005453-4057qib7 8793 2 actual actual JJ cord-005453-4057qib7 8793 3 cost cost NN cord-005453-4057qib7 8793 4 is be VBZ cord-005453-4057qib7 8793 5 undoubtedly undoubtedly RB cord-005453-4057qib7 8793 6 higher high JJR cord-005453-4057qib7 8793 7 as as IN cord-005453-4057qib7 8793 8 the the DT cord-005453-4057qib7 8793 9 hospitalization hospitalization NN cord-005453-4057qib7 8793 10 fee fee NN cord-005453-4057qib7 8793 11 for for IN cord-005453-4057qib7 8793 12 transplant transplant NN cord-005453-4057qib7 8793 13 recipients recipient NNS cord-005453-4057qib7 8793 14 is be VBZ cord-005453-4057qib7 8793 15 largely largely RB cord-005453-4057qib7 8793 16 underestimated underestimate VBN cord-005453-4057qib7 8793 17 in in IN cord-005453-4057qib7 8793 18 Greece Greece NNP cord-005453-4057qib7 8793 19 . . . cord-005453-4057qib7 8794 1 Considering consider VBG cord-005453-4057qib7 8794 2 not not RB cord-005453-4057qib7 8794 3 only only RB cord-005453-4057qib7 8794 4 the the DT cord-005453-4057qib7 8794 5 hematopoietic hematopoietic NN cord-005453-4057qib7 8794 6 but but CC cord-005453-4057qib7 8794 7 also also RB cord-005453-4057qib7 8794 8 the the DT cord-005453-4057qib7 8794 9 solid solid JJ cord-005453-4057qib7 8794 10 organ organ NN cord-005453-4057qib7 8794 11 transplant transplant NN cord-005453-4057qib7 8794 12 recipients recipient NNS cord-005453-4057qib7 8794 13 , , , cord-005453-4057qib7 8794 14 the the DT cord-005453-4057qib7 8794 15 financial financial JJ cord-005453-4057qib7 8794 16 burden burden NN cord-005453-4057qib7 8794 17 of of IN cord-005453-4057qib7 8794 18 antiviral antiviral JJ cord-005453-4057qib7 8794 19 treatment treatment NN cord-005453-4057qib7 8794 20 for for IN cord-005453-4057qib7 8794 21 national national JJ cord-005453-4057qib7 8794 22 economies economy NNS cord-005453-4057qib7 8794 23 is be VBZ cord-005453-4057qib7 8794 24 enormous enormous JJ cord-005453-4057qib7 8794 25 . . . cord-005453-4057qib7 8795 1 Given give VBN cord-005453-4057qib7 8795 2 that that DT cord-005453-4057qib7 8795 3 antiviral antiviral JJ cord-005453-4057qib7 8795 4 pharmacotherapy pharmacotherapy NN cord-005453-4057qib7 8795 5 is be VBZ cord-005453-4057qib7 8795 6 often often RB cord-005453-4057qib7 8795 7 associated associate VBN cord-005453-4057qib7 8795 8 with with IN cord-005453-4057qib7 8795 9 suboptimal suboptimal JJ cord-005453-4057qib7 8795 10 efficacy efficacy NN cord-005453-4057qib7 8795 11 , , , cord-005453-4057qib7 8795 12 toxicity toxicity NN cord-005453-4057qib7 8795 13 , , , cord-005453-4057qib7 8795 14 development development NN cord-005453-4057qib7 8795 15 of of IN cord-005453-4057qib7 8795 16 drug drug NN cord-005453-4057qib7 8795 17 resistance resistance NN cord-005453-4057qib7 8795 18 , , , cord-005453-4057qib7 8795 19 reactivation reactivation NN cord-005453-4057qib7 8795 20 recurrences recurrence NNS cord-005453-4057qib7 8795 21 and and CC cord-005453-4057qib7 8795 22 repeated repeat VBN cord-005453-4057qib7 8795 23 hospitalizations hospitalization NNS cord-005453-4057qib7 8795 24 , , , cord-005453-4057qib7 8795 25 it -PRON- PRP cord-005453-4057qib7 8795 26 is be VBZ cord-005453-4057qib7 8795 27 expected expect VBN cord-005453-4057qib7 8795 28 that that IN cord-005453-4057qib7 8795 29 a a DT cord-005453-4057qib7 8795 30 one one CD cord-005453-4057qib7 8795 31 - - HYPH cord-005453-4057qib7 8795 32 time time NN cord-005453-4057qib7 8795 33 treatment treatment NN cord-005453-4057qib7 8795 34 with with IN cord-005453-4057qib7 8795 35 multi multi JJ cord-005453-4057qib7 8795 36 - - JJ cord-005453-4057qib7 8795 37 virus virus JJ cord-005453-4057qib7 8795 38 - - HYPH cord-005453-4057qib7 8795 39 specific specific JJ cord-005453-4057qib7 8795 40 T t NN cord-005453-4057qib7 8795 41 cells cell NNS cord-005453-4057qib7 8795 42 , , , cord-005453-4057qib7 8795 43 able able JJ cord-005453-4057qib7 8795 44 to to TO cord-005453-4057qib7 8795 45 expand expand VB cord-005453-4057qib7 8795 46 in in IN cord-005453-4057qib7 8795 47 vivo vivo NN cord-005453-4057qib7 8795 48 and and CC cord-005453-4057qib7 8795 49 provide provide VB cord-005453-4057qib7 8795 50 a a DT cord-005453-4057qib7 8795 51 long long RB cord-005453-4057qib7 8795 52 - - HYPH cord-005453-4057qib7 8795 53 lasting last VBG cord-005453-4057qib7 8795 54 protection protection NN cord-005453-4057qib7 8795 55 without without IN cord-005453-4057qib7 8795 56 significant significant JJ cord-005453-4057qib7 8795 57 toxicity toxicity NN cord-005453-4057qib7 8795 58 , , , cord-005453-4057qib7 8795 59 will will MD cord-005453-4057qib7 8795 60 serve serve VB cord-005453-4057qib7 8795 61 as as IN cord-005453-4057qib7 8795 62 a a DT cord-005453-4057qib7 8795 63 powerful powerful JJ cord-005453-4057qib7 8795 64 and and CC cord-005453-4057qib7 8795 65 costeffective costeffective JJ cord-005453-4057qib7 8795 66 treatment treatment NN cord-005453-4057qib7 8795 67 over over IN cord-005453-4057qib7 8795 68 conventional conventional JJ cord-005453-4057qib7 8795 69 pharmacotherapy pharmacotherapy NN cord-005453-4057qib7 8795 70 . . . cord-005453-4057qib7 8796 1 Disclosure disclosure NN cord-005453-4057qib7 8796 2 : : : cord-005453-4057qib7 8796 3 Nothing nothing NN cord-005453-4057qib7 8796 4 to to TO cord-005453-4057qib7 8796 5 declare declare VB cord-005453-4057qib7 8796 6 Methods method NNS cord-005453-4057qib7 8797 1 : : : cord-005453-4057qib7 8797 2 This this DT cord-005453-4057qib7 8797 3 is be VBZ cord-005453-4057qib7 8797 4 a a DT cord-005453-4057qib7 8797 5 single single JJ cord-005453-4057qib7 8797 6 - - HYPH cord-005453-4057qib7 8797 7 centre centre NN cord-005453-4057qib7 8797 8 retrospective retrospective JJ cord-005453-4057qib7 8797 9 analysis analysis NN cord-005453-4057qib7 8797 10 of of IN cord-005453-4057qib7 8797 11 293 293 CD cord-005453-4057qib7 8797 12 consecutive consecutive JJ cord-005453-4057qib7 8797 13 patients patient NNS cord-005453-4057qib7 8797 14 who who WP cord-005453-4057qib7 8797 15 underwent undergo VBD cord-005453-4057qib7 8797 16 TCD TCD NNP cord-005453-4057qib7 8797 17 allo allo NNP cord-005453-4057qib7 8797 18 - - HYPH cord-005453-4057qib7 8797 19 HSCTs hsct NNS cord-005453-4057qib7 8797 20 for for IN cord-005453-4057qib7 8797 21 myeloid myeloid JJ cord-005453-4057qib7 8797 22 malignancies malignancy NNS cord-005453-4057qib7 8797 23 between between IN cord-005453-4057qib7 8797 24 January January NNP cord-005453-4057qib7 8797 25 2012-June 2012-june CD cord-005453-4057qib7 8797 26 2016 2016 CD cord-005453-4057qib7 8797 27 . . . cord-005453-4057qib7 8798 1 EBV EBV NNP cord-005453-4057qib7 8798 2 - - HYPH cord-005453-4057qib7 8798 3 DNA DNA NNP cord-005453-4057qib7 8798 4 was be VBD cord-005453-4057qib7 8798 5 monitored monitor VBN cord-005453-4057qib7 8798 6 frequently frequently RB cord-005453-4057qib7 8798 7 on on IN cord-005453-4057qib7 8798 8 whole whole JJ cord-005453-4057qib7 8798 9 blood blood NN cord-005453-4057qib7 8798 10 samples sample NNS cord-005453-4057qib7 8798 11 with with IN cord-005453-4057qib7 8798 12 standardised standardised JJ cord-005453-4057qib7 8798 13 quantitative quantitative JJ cord-005453-4057qib7 8798 14 real real JJ cord-005453-4057qib7 8798 15 - - HYPH cord-005453-4057qib7 8798 16 time time NN cord-005453-4057qib7 8798 17 PCR PCR NNP cord-005453-4057qib7 8798 18 . . . cord-005453-4057qib7 8799 1 Serum serum NN cord-005453-4057qib7 8799 2 protein protein NN cord-005453-4057qib7 8799 3 electrophoresis electrophoresis NN cord-005453-4057qib7 8799 4 was be VBD cord-005453-4057qib7 8799 5 routinely routinely RB cord-005453-4057qib7 8799 6 tested test VBN cord-005453-4057qib7 8799 7 with with IN cord-005453-4057qib7 8799 8 immunoglobulin immunoglobulin NN cord-005453-4057qib7 8799 9 subclasses subclass NNS cord-005453-4057qib7 8799 10 identified identify VBN cord-005453-4057qib7 8799 11 by by IN cord-005453-4057qib7 8799 12 immunofixation immunofixation NN cord-005453-4057qib7 8799 13 electrophoresis electrophoresis NNP cord-005453-4057qib7 8799 14 . . . cord-005453-4057qib7 8800 1 Histological histological JJ cord-005453-4057qib7 8800 2 confirmation confirmation NN cord-005453-4057qib7 8800 3 of of IN cord-005453-4057qib7 8800 4 PTLD PTLD NNP cord-005453-4057qib7 8800 5 was be VBD cord-005453-4057qib7 8800 6 based base VBN cord-005453-4057qib7 8800 7 on on IN cord-005453-4057qib7 8800 8 standard standard NN cord-005453-4057qib7 8800 9 WHO WHO NNP cord-005453-4057qib7 8800 10 diagnostic diagnostic JJ cord-005453-4057qib7 8800 11 criteria criterion NNS cord-005453-4057qib7 8800 12 ( ( -LRB- cord-005453-4057qib7 8800 13 ' ' `` cord-005453-4057qib7 8800 14 proven prove VBN cord-005453-4057qib7 8800 15 ' ' '' cord-005453-4057qib7 8800 16 ) ) -RRB- cord-005453-4057qib7 8800 17 , , , cord-005453-4057qib7 8800 18 while while IN cord-005453-4057qib7 8800 19 those those DT cord-005453-4057qib7 8800 20 without without IN cord-005453-4057qib7 8800 21 biopsy biopsy NN cord-005453-4057qib7 8800 22 were be VBD cord-005453-4057qib7 8800 23 classed class VBN cord-005453-4057qib7 8800 24 as as IN cord-005453-4057qib7 8800 25 ' ' `` cord-005453-4057qib7 8800 26 probable probable JJ cord-005453-4057qib7 8800 27 ' ' '' cord-005453-4057qib7 8800 28 based base VBN cord-005453-4057qib7 8800 29 on on IN cord-005453-4057qib7 8800 30 clinical clinical JJ cord-005453-4057qib7 8800 31 & & CC cord-005453-4057qib7 8800 32 radiological radiological JJ cord-005453-4057qib7 8800 33 criteria criterion NNS cord-005453-4057qib7 8800 34 as as IN cord-005453-4057qib7 8800 35 defined define VBN cord-005453-4057qib7 8800 36 by by IN cord-005453-4057qib7 8800 37 ECIL-6 ECIL-6 NNP cord-005453-4057qib7 8800 38 guidelines guideline NNS cord-005453-4057qib7 8800 39 . . . cord-005453-4057qib7 8801 1 Results result NNS cord-005453-4057qib7 8801 2 : : : cord-005453-4057qib7 8802 1 Majority majority NN cord-005453-4057qib7 8802 2 of of IN cord-005453-4057qib7 8802 3 patients patient NNS cord-005453-4057qib7 8802 4 had have VBD cord-005453-4057qib7 8802 5 AML(n-152/293 aml(n-152/293 CD cord-005453-4057qib7 8802 6 ) ) -RRB- cord-005453-4057qib7 8802 7 and and CC cord-005453-4057qib7 8802 8 MDS(n-107/293 MDS(n-107/293 NNP cord-005453-4057qib7 8802 9 ) ) -RRB- cord-005453-4057qib7 8802 10 with with IN cord-005453-4057qib7 8802 11 a a DT cord-005453-4057qib7 8802 12 median median JJ cord-005453-4057qib7 8802 13 age age NN cord-005453-4057qib7 8802 14 of of IN cord-005453-4057qib7 8802 15 58 58 CD cord-005453-4057qib7 8802 16 years(range years(range NNS cord-005453-4057qib7 8802 17 . . . cord-005453-4057qib7 8803 1 Median median JJ cord-005453-4057qib7 8803 2 follow follow VBP cord-005453-4057qib7 8803 3 up up IN cord-005453-4057qib7 8803 4 of of IN cord-005453-4057qib7 8803 5 survivors survivor NNS cord-005453-4057qib7 8803 6 was be VBD cord-005453-4057qib7 8803 7 32 32 CD cord-005453-4057qib7 8803 8 months(range months(range CD cord-005453-4057qib7 8803 9 4 4 CD cord-005453-4057qib7 8803 10 - - SYM cord-005453-4057qib7 8803 11 65 65 CD cord-005453-4057qib7 8803 12 ) ) -RRB- cord-005453-4057qib7 8803 13 . . . cord-005453-4057qib7 8804 1 Majority majority NN cord-005453-4057qib7 8804 2 of of IN cord-005453-4057qib7 8804 3 patients(n-220/293;75 patients(n-220/293;75 NNP cord-005453-4057qib7 8804 4 % % NN cord-005453-4057qib7 8804 5 ) ) -RRB- cord-005453-4057qib7 8804 6 developed develop VBD cord-005453-4057qib7 8804 7 EBV EBV NNP cord-005453-4057qib7 8804 8 - - HYPH cord-005453-4057qib7 8804 9 R R NNP cord-005453-4057qib7 8804 10 with with IN cord-005453-4057qib7 8804 11 a a DT cord-005453-4057qib7 8804 12 median median JJ cord-005453-4057qib7 8804 13 time time NN cord-005453-4057qib7 8804 14 of of IN cord-005453-4057qib7 8804 15 79 79 CD cord-005453-4057qib7 8804 16 days[Inter days[inter NN cord-005453-4057qib7 8804 17 quartile quartile NNP cord-005453-4057qib7 8804 18 range(IQR range(IQR NNP cord-005453-4057qib7 8804 19 ) ) -RRB- cord-005453-4057qib7 8804 20 27 27 CD cord-005453-4057qib7 8804 21 - - SYM cord-005453-4057qib7 8804 22 160 160 CD cord-005453-4057qib7 8804 23 days day NNS cord-005453-4057qib7 8804 24 ] ] -RRB- cord-005453-4057qib7 8804 25 & & CC cord-005453-4057qib7 8804 26 higher high JJR cord-005453-4057qib7 8804 27 cumulative cumulative JJ cord-005453-4057qib7 8804 28 incidence incidence NN cord-005453-4057qib7 8804 29 with with IN cord-005453-4057qib7 8804 30 ATG(n-132 ATG(n-132 NNP cord-005453-4057qib7 8804 31 ) ) -RRB- cord-005453-4057qib7 8804 32 versus versus IN cord-005453-4057qib7 8804 33 Alemtuzumab(n-161)(p alemtuzumab(n-161)(p IN cord-005453-4057qib7 8804 34 < < XX cord-005453-4057qib7 8804 35 0.001 0.001 CD cord-005453-4057qib7 8804 36 ) ) -RRB- cord-005453-4057qib7 8804 37 . . . cord-005453-4057qib7 8805 1 Figure-1a Figure-1a NNP cord-005453-4057qib7 8805 2 shows show VBZ cord-005453-4057qib7 8805 3 schematic schematic JJ cord-005453-4057qib7 8805 4 representation representation NN cord-005453-4057qib7 8805 5 of of IN cord-005453-4057qib7 8805 6 EBV EBV NNP cord-005453-4057qib7 8805 7 and and CC cord-005453-4057qib7 8805 8 PTLD PTLD NNP cord-005453-4057qib7 8805 9 events event NNS cord-005453-4057qib7 8805 10 ( ( -LRB- cord-005453-4057qib7 8805 11 cumulative cumulative JJ cord-005453-4057qib7 8805 12 incidence incidence NN cord-005453-4057qib7 8805 13 of of IN cord-005453-4057qib7 8805 14 6.8%(95%CI-4.0%-10.6 6.8%(95%ci-4.0%-10.6 CD cord-005453-4057qib7 8805 15 % % NN cord-005453-4057qib7 8805 16 ) ) -RRB- cord-005453-4057qib7 8805 17 at at IN cord-005453-4057qib7 8805 18 12 12 CD cord-005453-4057qib7 8805 19 months month NNS cord-005453-4057qib7 8805 20 ) ) -RRB- cord-005453-4057qib7 8805 21 . . . cord-005453-4057qib7 8806 1 Significantly significantly RB cord-005453-4057qib7 8806 2 higher high JJR cord-005453-4057qib7 8806 3 peak peak NN cord-005453-4057qib7 8806 4 EBV EBV NNP cord-005453-4057qib7 8806 5 DNA dna NN cord-005453-4057qib7 8806 6 viral viral JJ cord-005453-4057qib7 8806 7 load(EVL load(evl NN cord-005453-4057qib7 8806 8 ) ) -RRB- cord-005453-4057qib7 8806 9 were be VBD cord-005453-4057qib7 8806 10 noted note VBN cord-005453-4057qib7 8806 11 in in IN cord-005453-4057qib7 8806 12 patients patient NNS cord-005453-4057qib7 8806 13 with with IN cord-005453-4057qib7 8806 14 PTLD(p- ptld(p- CD cord-005453-4057qib7 8806 15 < < XX cord-005453-4057qib7 8806 16 0.001 0.001 CD cord-005453-4057qib7 8806 17 ) ) -RRB- cord-005453-4057qib7 8806 18 . . . cord-005453-4057qib7 8807 1 Development development NN cord-005453-4057qib7 8807 2 of of IN cord-005453-4057qib7 8807 3 post post JJ cord-005453-4057qib7 8807 4 - - JJ cord-005453-4057qib7 8807 5 HSCT HSCT NNP cord-005453-4057qib7 8807 6 MG MG NNP cord-005453-4057qib7 8807 7 was be VBD cord-005453-4057qib7 8807 8 observed observe VBN cord-005453-4057qib7 8807 9 in in IN cord-005453-4057qib7 8807 10 29%(n-85/292 29%(n-85/292 CD cord-005453-4057qib7 8807 11 ) ) -RRB- cord-005453-4057qib7 8807 12 . . . cord-005453-4057qib7 8808 1 ROC ROC NNP cord-005453-4057qib7 8808 2 curve curve NN cord-005453-4057qib7 8808 3 identified identify VBD cord-005453-4057qib7 8808 4 peak peak NN cord-005453-4057qib7 8808 5 blood blood NN cord-005453-4057qib7 8808 6 EVL>150,000 EVL>150,000 . cord-005453-4057qib7 8809 1 copies copy NNS cord-005453-4057qib7 8809 2 / / SYM cord-005453-4057qib7 8809 3 ml ml XX cord-005453-4057qib7 8809 4 significantly significantly RB cord-005453-4057qib7 8809 5 correlated correlate VBD cord-005453-4057qib7 8809 6 with with IN cord-005453-4057qib7 8809 7 risk risk NN cord-005453-4057qib7 8809 8 of of IN cord-005453-4057qib7 8809 9 developing develop VBG cord-005453-4057qib7 8809 10 PTLD PTLD NNP cord-005453-4057qib7 8809 11 ( ( -LRB- cord-005453-4057qib7 8809 12 sensitivity-70.6%,specificity-79.4%;AUC-0.82,p sensitivity-70.6%,specificity-79.4%;auc-0.82,p NN cord-005453-4057qib7 8809 13 < < XX cord-005453-4057qib7 8809 14 0.001 0.001 CD cord-005453-4057qib7 8809 15 ) ) -RRB- cord-005453-4057qib7 8809 16 . . . cord-005453-4057qib7 8810 1 Based base VBN cord-005453-4057qib7 8810 2 on on IN cord-005453-4057qib7 8810 3 these these DT cord-005453-4057qib7 8810 4 estimates estimate NNS cord-005453-4057qib7 8810 5 , , , cord-005453-4057qib7 8810 6 subgroup subgroup NN cord-005453-4057qib7 8810 7 of of IN cord-005453-4057qib7 8810 8 patients patient NNS cord-005453-4057qib7 8810 9 with with IN cord-005453-4057qib7 8810 10 no no DT cord-005453-4057qib7 8810 11 EBV EBV NNP cord-005453-4057qib7 8810 12 - - HYPH cord-005453-4057qib7 8810 13 R(n-72/292 R(n-72/292 NNP cord-005453-4057qib7 8810 14 ) ) -RRB- cord-005453-4057qib7 8810 15 , , , cord-005453-4057qib7 8810 16 peak peak NN cord-005453-4057qib7 8810 17 EVL EVL NNP cord-005453-4057qib7 8810 18 < < XX cord-005453-4057qib7 8810 19 150,000 150,000 CD cord-005453-4057qib7 8810 20 ( ( -LRB- cord-005453-4057qib7 8810 21 < < NNP cord-005453-4057qib7 8810 22 150k)copies/ 150k)copies/ CD cord-005453-4057qib7 8810 23 ml(n-165/292 ml(n-165/292 NNP cord-005453-4057qib7 8810 24 ) ) -RRB- cord-005453-4057qib7 8810 25 & & CC cord-005453-4057qib7 8810 26 > > NNP cord-005453-4057qib7 8810 27 150,000(>150k)copies 150,000(>150k)copies CD cord-005453-4057qib7 8810 28 / / SYM cord-005453-4057qib7 8810 29 ml(n-55/292 ml(n-55/292 CD cord-005453-4057qib7 8810 30 ) ) -RRB- cord-005453-4057qib7 8810 31 were be VBD cord-005453-4057qib7 8810 32 categorised categorise VBN cord-005453-4057qib7 8810 33 in in IN cord-005453-4057qib7 8810 34 6 6 CD cord-005453-4057qib7 8810 35 groups group NNS cord-005453-4057qib7 8810 36 along along IN cord-005453-4057qib7 8810 37 patients patient NNS cord-005453-4057qib7 8810 38 with with IN cord-005453-4057qib7 8810 39 / / SYM cord-005453-4057qib7 8810 40 without without IN cord-005453-4057qib7 8810 41 MG MG NNP cord-005453-4057qib7 8810 42 accordingly accordingly RB cord-005453-4057qib7 8810 43 ( ( -LRB- cord-005453-4057qib7 8810 44 Groups group NNS cord-005453-4057qib7 8810 45 1 1 CD cord-005453-4057qib7 8810 46 - - HYPH cord-005453-4057qib7 8810 47 6;Figure-1b 6;figure-1b CD cord-005453-4057qib7 8810 48 ) ) -RRB- cord-005453-4057qib7 8810 49 . . . cord-005453-4057qib7 8811 1 Patients patient NNS cord-005453-4057qib7 8811 2 with with IN cord-005453-4057qib7 8811 3 EBV EBV NNP cord-005453-4057qib7 8811 4 - - HYPH cord-005453-4057qib7 8811 5 R R NNP cord-005453-4057qib7 8811 6 had have VBD cord-005453-4057qib7 8811 7 significantly significantly RB cord-005453-4057qib7 8811 8 better well JJR cord-005453-4057qib7 8811 9 OS OS NNP cord-005453-4057qib7 8811 10 [ [ -LRB- cord-005453-4057qib7 8811 11 5-year 5-year CD cord-005453-4057qib7 8811 12 OS os NN cord-005453-4057qib7 8811 13 of of IN cord-005453-4057qib7 8811 14 52 52 CD cord-005453-4057qib7 8811 15 % % NN cord-005453-4057qib7 8811 16 vs vs IN cord-005453-4057qib7 8811 17 35%(no 35%(no CD cord-005453-4057qib7 8811 18 EBV EBV NNP cord-005453-4057qib7 8811 19 - - HYPH cord-005453-4057qib7 8811 20 R);Log r);log JJ cord-005453-4057qib7 8811 21 - - HYPH cord-005453-4057qib7 8811 22 rank rank NN cord-005453-4057qib7 8811 23 p p NN cord-005453-4057qib7 8811 24 < < XX cord-005453-4057qib7 8812 1 0.001],with 0.001],with NNP cord-005453-4057qib7 8812 2 this this DT cord-005453-4057qib7 8812 3 survival survival NN cord-005453-4057qib7 8812 4 benefit benefit NN cord-005453-4057qib7 8812 5 mainly mainly RB cord-005453-4057qib7 8812 6 driven drive VBN cord-005453-4057qib7 8812 7 by by IN cord-005453-4057qib7 8812 8 subgroup subgroup NN cord-005453-4057qib7 8812 9 of of IN cord-005453-4057qib7 8812 10 patients patient NNS cord-005453-4057qib7 8812 11 with with IN cord-005453-4057qib7 8812 12 lower low JJR cord-005453-4057qib7 8812 13 EVL EVL NNP cord-005453-4057qib7 8812 14 ( ( -LRB- cord-005453-4057qib7 8812 15 < < XX cord-005453-4057qib7 8812 16 150k)(p 150k)(p CD cord-005453-4057qib7 8812 17 < < XX cord-005453-4057qib7 8812 18 0.001 0.001 CD cord-005453-4057qib7 8812 19 ) ) -RRB- cord-005453-4057qib7 8812 20 . . . cord-005453-4057qib7 8813 1 PTLD PTLD NNP cord-005453-4057qib7 8813 2 patients patient NNS cord-005453-4057qib7 8813 3 had have VBD cord-005453-4057qib7 8813 4 trend trend NN cord-005453-4057qib7 8813 5 towards towards IN cord-005453-4057qib7 8813 6 inferior inferior JJ cord-005453-4057qib7 8813 7 3-year 3-year NNP cord-005453-4057qib7 8813 8 OS(15 OS(15 NNS cord-005453-4057qib7 8813 9 % % NN cord-005453-4057qib7 8813 10 vs vs IN cord-005453-4057qib7 8813 11 54%;p-0.051 54%;p-0.051 CD cord-005453-4057qib7 8813 12 ) ) -RRB- cord-005453-4057qib7 8813 13 . . . cord-005453-4057qib7 8814 1 Patients patient NNS cord-005453-4057qib7 8814 2 with with IN cord-005453-4057qib7 8814 3 MG MG NNP cord-005453-4057qib7 8814 4 had have VBD cord-005453-4057qib7 8814 5 a a DT cord-005453-4057qib7 8814 6 significantly significantly RB cord-005453-4057qib7 8814 7 better well JJR cord-005453-4057qib7 8814 8 OS os NN cord-005453-4057qib7 8814 9 irrespective irrespective RB cord-005453-4057qib7 8814 10 of of IN cord-005453-4057qib7 8814 11 degree degree NN cord-005453-4057qib7 8814 12 of of IN cord-005453-4057qib7 8814 13 EVL EVL NNP cord-005453-4057qib7 8814 14 ( ( -LRB- cord-005453-4057qib7 8814 15 Group Group NNP cord-005453-4057qib7 8814 16 1- 1- CD cord-005453-4057qib7 8815 1 3,p 3,p LS cord-005453-4057qib7 8815 2 < < XX cord-005453-4057qib7 8815 3 0.001).We 0.001).we CD cord-005453-4057qib7 8815 4 report report VBP cord-005453-4057qib7 8815 5 a a DT cord-005453-4057qib7 8815 6 ' ' `` cord-005453-4057qib7 8815 7 sweet sweet JJ cord-005453-4057qib7 8815 8 spot spot NN cord-005453-4057qib7 8815 9 ' ' '' cord-005453-4057qib7 8815 10 of of IN cord-005453-4057qib7 8815 11 low low JJ cord-005453-4057qib7 8815 12 EVL EVL NNP cord-005453-4057qib7 8815 13 & & CC cord-005453-4057qib7 8815 14 presence presence NN cord-005453-4057qib7 8815 15 of of IN cord-005453-4057qib7 8815 16 MG MG NNP cord-005453-4057qib7 8815 17 in in IN cord-005453-4057qib7 8815 18 these these DT cord-005453-4057qib7 8815 19 patients patient NNS cord-005453-4057qib7 8815 20 , , , cord-005453-4057qib7 8815 21 with with IN cord-005453-4057qib7 8815 22 a a DT cord-005453-4057qib7 8815 23 clear clear JJ cord-005453-4057qib7 8815 24 survival survival NN cord-005453-4057qib7 8815 25 advantage advantage NN cord-005453-4057qib7 8815 26 compared compare VBN cord-005453-4057qib7 8815 27 to to IN cord-005453-4057qib7 8815 28 those those DT cord-005453-4057qib7 8815 29 with with IN cord-005453-4057qib7 8815 30 no no DT cord-005453-4057qib7 8815 31 EBV EBV NNP cord-005453-4057qib7 8815 32 - - HYPH cord-005453-4057qib7 8815 33 R R NNP cord-005453-4057qib7 8815 34 and/or and/or CC cord-005453-4057qib7 8815 35 no no DT cord-005453-4057qib7 8815 36 Mprotein Mprotein NNP cord-005453-4057qib7 8816 1 ( ( -LRB- cord-005453-4057qib7 8816 2 Group-2 Group-2 NNP cord-005453-4057qib7 8816 3 5-year 5-year CD cord-005453-4057qib7 8816 4 OS OS NNP cord-005453-4057qib7 8816 5 62 62 CD cord-005453-4057qib7 8816 6 % % NN cord-005453-4057qib7 8816 7 vs vs IN cord-005453-4057qib7 8816 8 27 27 CD cord-005453-4057qib7 8816 9 % % NN cord-005453-4057qib7 8816 10 in in IN cord-005453-4057qib7 8816 11 Group-6 Group-6 NNP cord-005453-4057qib7 8816 12 ; ; : cord-005453-4057qib7 8816 13 HR-0.15;95%CI:0.06 hr-0.15;95%ci:0.06 CD cord-005453-4057qib7 8816 14 - - HYPH cord-005453-4057qib7 8816 15 0.34;p 0.34;p CD cord-005453-4057qib7 8816 16 < < XX cord-005453-4057qib7 8816 17 0.001;Figure1b 0.001;figure1b CD cord-005453-4057qib7 8816 18 ) ) -RRB- cord-005453-4057qib7 8816 19 . . . cord-005453-4057qib7 8817 1 Overall overall JJ cord-005453-4057qib7 8817 2 cumulative cumulative JJ cord-005453-4057qib7 8817 3 incidence incidence NN cord-005453-4057qib7 8817 4 of of IN cord-005453-4057qib7 8817 5 relapse relapse NN cord-005453-4057qib7 8817 6 ( ( -LRB- cord-005453-4057qib7 8817 7 CIR CIR NNP cord-005453-4057qib7 8817 8 ) ) -RRB- cord-005453-4057qib7 8817 9 was be VBD cord-005453-4057qib7 8817 10 28%(95%CI:23 28%(95%ci:23 CD cord-005453-4057qib7 8817 11 - - SYM cord-005453-4057qib7 8817 12 37 37 CD cord-005453-4057qib7 8817 13 ) ) -RRB- cord-005453-4057qib7 8817 14 and and CC cord-005453-4057qib7 8817 15 non non JJ cord-005453-4057qib7 8817 16 - - JJ cord-005453-4057qib7 8817 17 relapse relapse JJ cord-005453-4057qib7 8817 18 - - HYPH cord-005453-4057qib7 8817 19 mortality(NRM mortality(NRM NNP cord-005453-4057qib7 8817 20 ) ) -RRB- cord-005453-4057qib7 8817 21 of of IN cord-005453-4057qib7 8817 22 24%(95%CI:18.6 24%(95%ci:18.6 CD cord-005453-4057qib7 8817 23 - - SYM cord-005453-4057qib7 8817 24 30 30 CD cord-005453-4057qib7 8817 25 ) ) -RRB- cord-005453-4057qib7 8817 26 at at IN cord-005453-4057qib7 8817 27 5 5 CD cord-005453-4057qib7 8817 28 years year NNS cord-005453-4057qib7 8817 29 . . . cord-005453-4057qib7 8818 1 Multivariate Multivariate NNP cord-005453-4057qib7 8818 2 analysis(MVA analysis(MVA NNP cord-005453-4057qib7 8818 3 ) ) -RRB- cord-005453-4057qib7 8818 4 revealed reveal VBD cord-005453-4057qib7 8818 5 absence absence NN cord-005453-4057qib7 8818 6 of of IN cord-005453-4057qib7 8818 7 M M NNP cord-005453-4057qib7 8818 8 - - HYPH cord-005453-4057qib7 8818 9 protein protein NN cord-005453-4057qib7 8818 10 , , , cord-005453-4057qib7 8818 11 high high JJ cord-005453-4057qib7 8818 12 EVL EVL NNP cord-005453-4057qib7 8818 13 ( ( -LRB- cord-005453-4057qib7 8818 14 > > NFP cord-005453-4057qib7 8818 15 150k 150k CD cord-005453-4057qib7 8818 16 copies copy NNS cord-005453-4057qib7 8818 17 / / SYM cord-005453-4057qib7 8818 18 ml ml NN cord-005453-4057qib7 8818 19 ) ) -RRB- cord-005453-4057qib7 8818 20 or or CC cord-005453-4057qib7 8818 21 no no DT cord-005453-4057qib7 8818 22 EBV EBV NNP cord-005453-4057qib7 8818 23 - - HYPH cord-005453-4057qib7 8818 24 R r NN cord-005453-4057qib7 8818 25 and and CC cord-005453-4057qib7 8818 26 absence absence NN cord-005453-4057qib7 8818 27 of of IN cord-005453-4057qib7 8818 28 any any DT cord-005453-4057qib7 8818 29 GVHD GVHD NNP cord-005453-4057qib7 8818 30 as as IN cord-005453-4057qib7 8818 31 significant significant JJ cord-005453-4057qib7 8818 32 factors factor NNS cord-005453-4057qib7 8818 33 for for IN cord-005453-4057qib7 8818 34 high high JJ cord-005453-4057qib7 8818 35 CIR CIR NNP cord-005453-4057qib7 8818 36 . . . cord-005453-4057qib7 8819 1 Similarly similarly RB cord-005453-4057qib7 8819 2 , , , cord-005453-4057qib7 8819 3 high high JJ cord-005453-4057qib7 8819 4 EVL EVL NNP cord-005453-4057qib7 8819 5 or or CC cord-005453-4057qib7 8819 6 no no DT cord-005453-4057qib7 8819 7 EBV EBV NNP cord-005453-4057qib7 8819 8 - - HYPH cord-005453-4057qib7 8819 9 R r NN cord-005453-4057qib7 8819 10 , , , cord-005453-4057qib7 8819 11 absence absence NN cord-005453-4057qib7 8819 12 of of IN cord-005453-4057qib7 8819 13 M M NNP cord-005453-4057qib7 8819 14 - - HYPH cord-005453-4057qib7 8819 15 protein protein NNP cord-005453-4057qib7 8819 16 and and CC cord-005453-4057qib7 8819 17 ITU ITU NNP cord-005453-4057qib7 8819 18 admission admission NN cord-005453-4057qib7 8819 19 were be VBD cord-005453-4057qib7 8819 20 significant significant JJ cord-005453-4057qib7 8819 21 predictors predictor NNS cord-005453-4057qib7 8819 22 of of IN cord-005453-4057qib7 8819 23 high high JJ cord-005453-4057qib7 8819 24 NRM NRM NNP cord-005453-4057qib7 8819 25 . . . cord-005453-4057qib7 8820 1 Conclusions conclusion NNS cord-005453-4057qib7 8820 2 : : : cord-005453-4057qib7 8821 1 This this DT cord-005453-4057qib7 8821 2 study study NN cord-005453-4057qib7 8821 3 adds add VBZ cord-005453-4057qib7 8821 4 to to IN cord-005453-4057qib7 8821 5 our -PRON- PRP$ cord-005453-4057qib7 8821 6 understanding understanding NN cord-005453-4057qib7 8821 7 of of IN cord-005453-4057qib7 8821 8 role role NN cord-005453-4057qib7 8821 9 of of IN cord-005453-4057qib7 8821 10 EBV EBV NNP cord-005453-4057qib7 8821 11 viraemia viraemia NNP cord-005453-4057qib7 8821 12 & & CC cord-005453-4057qib7 8821 13 associated associate VBD cord-005453-4057qib7 8821 14 MG MG NNP cord-005453-4057qib7 8821 15 in in IN cord-005453-4057qib7 8821 16 TCD TCD NNP cord-005453-4057qib7 8821 17 - - HYPH cord-005453-4057qib7 8821 18 HSCTs HSCTs NNP cord-005453-4057qib7 8821 19 while while IN cord-005453-4057qib7 8821 20 highlighting highlight VBG cord-005453-4057qib7 8821 21 its -PRON- PRP$ cord-005453-4057qib7 8821 22 significant significant JJ cord-005453-4057qib7 8821 23 impact impact NN cord-005453-4057qib7 8821 24 on on IN cord-005453-4057qib7 8821 25 risk risk NN cord-005453-4057qib7 8821 26 of of IN cord-005453-4057qib7 8821 27 PTLD PTLD NNP cord-005453-4057qib7 8821 28 , , , cord-005453-4057qib7 8821 29 OS OS NNP cord-005453-4057qib7 8821 30 , , , cord-005453-4057qib7 8821 31 NRM NRM NNP cord-005453-4057qib7 8821 32 & & CC cord-005453-4057qib7 8821 33 CIR CIR NNP cord-005453-4057qib7 8821 34 . . . cord-005453-4057qib7 8822 1 Low low JJ cord-005453-4057qib7 8822 2 EBV EBV NNP cord-005453-4057qib7 8822 3 burden burden NN cord-005453-4057qib7 8822 4 and and CC cord-005453-4057qib7 8822 5 development development NN cord-005453-4057qib7 8822 6 of of IN cord-005453-4057qib7 8822 7 MG MG NNP cord-005453-4057qib7 8822 8 is be VBZ cord-005453-4057qib7 8822 9 protective protective JJ cord-005453-4057qib7 8822 10 with with IN cord-005453-4057qib7 8822 11 significantly significantly RB cord-005453-4057qib7 8822 12 better well JJR cord-005453-4057qib7 8822 13 survival survival NN cord-005453-4057qib7 8822 14 outcomes outcome NNS cord-005453-4057qib7 8822 15 and and CC cord-005453-4057qib7 8822 16 we -PRON- PRP cord-005453-4057qib7 8822 17 recommend recommend VBP cord-005453-4057qib7 8822 18 pre pre JJ cord-005453-4057qib7 8822 19 - - JJ cord-005453-4057qib7 8822 20 emptive emptive JJ cord-005453-4057qib7 8822 21 approach approach NN cord-005453-4057qib7 8822 22 of of IN cord-005453-4057qib7 8822 23 using use VBG cord-005453-4057qib7 8822 24 Rituximab Rituximab NNP cord-005453-4057qib7 8822 25 for for IN cord-005453-4057qib7 8822 26 EBV EBV NNP cord-005453-4057qib7 8822 27 - - HYPH cord-005453-4057qib7 8822 28 R R NNP cord-005453-4057qib7 8822 29 /PTLD /ptld NN cord-005453-4057qib7 8822 30 is be VBZ cord-005453-4057qib7 8822 31 best well RBS cord-005453-4057qib7 8822 32 employed employ VBN cord-005453-4057qib7 8822 33 at at IN cord-005453-4057qib7 8822 34 higher high JJR cord-005453-4057qib7 8822 35 EBV EBV NNP cord-005453-4057qib7 8822 36 burden burden NN cord-005453-4057qib7 8822 37 ( ( -LRB- cord-005453-4057qib7 8822 38 e.g. e.g. RB cord-005453-4057qib7 8822 39 > > XX cord-005453-4057qib7 8822 40 150k 150k CD cord-005453-4057qib7 8822 41 copies copy NNS cord-005453-4057qib7 8822 42 / / SYM cord-005453-4057qib7 8822 43 ml ml NN cord-005453-4057qib7 8822 44 DNA DNA NNP cord-005453-4057qib7 8822 45 ) ) -RRB- cord-005453-4057qib7 8822 46 in in IN cord-005453-4057qib7 8822 47 high high JJ cord-005453-4057qib7 8822 48 risk risk NN cord-005453-4057qib7 8822 49 patients patient NNS cord-005453-4057qib7 8822 50 and and CC cord-005453-4057qib7 8822 51 be be VB cord-005453-4057qib7 8822 52 prospectively prospectively RB cord-005453-4057qib7 8822 53 evaluated evaluate VBN cord-005453-4057qib7 8822 54 in in IN cord-005453-4057qib7 8822 55 future future JJ cord-005453-4057qib7 8822 56 studies study NNS cord-005453-4057qib7 8822 57 . . . cord-005453-4057qib7 8823 1 Clinical clinical JJ cord-005453-4057qib7 8823 2 Trial Trial NNP cord-005453-4057qib7 8823 3 Registry Registry NNP cord-005453-4057qib7 8823 4 : : : cord-005453-4057qib7 8824 1 n n LS cord-005453-4057qib7 8824 2 / / SYM cord-005453-4057qib7 8824 3 a a DT cord-005453-4057qib7 8824 4 Disclosure disclosure NN cord-005453-4057qib7 8824 5 : : : cord-005453-4057qib7 8824 6 Nothing nothing NN cord-005453-4057qib7 8824 7 to to TO cord-005453-4057qib7 8824 8 declare declare VB cord-005453-4057qib7 8824 9 P394 P394 NNP cord-005453-4057qib7 8824 10 Impact Impact NNP cord-005453-4057qib7 8824 11 of of IN cord-005453-4057qib7 8824 12 early early JJ cord-005453-4057qib7 8824 13 candidemia candidemia NN cord-005453-4057qib7 8824 14 on on IN cord-005453-4057qib7 8824 15 the the DT cord-005453-4057qib7 8824 16 long long JJ cord-005453-4057qib7 8824 17 - - HYPH cord-005453-4057qib7 8824 18 term term NN cord-005453-4057qib7 8824 19 outcome outcome NN cord-005453-4057qib7 8824 20 of of IN cord-005453-4057qib7 8824 21 allogeneic allogeneic JJ cord-005453-4057qib7 8824 22 hematopoietic hematopoietic JJ cord-005453-4057qib7 8824 23 stem stem NN cord-005453-4057qib7 8824 24 cell cell NN cord-005453-4057qib7 8824 25 transplant transplant NN cord-005453-4057qib7 8824 26 in in IN cord-005453-4057qib7 8824 27 non non JJ cord-005453-4057qib7 8824 28 leukemic leukemic JJ cord-005453-4057qib7 8824 29 patients patient NNS cord-005453-4057qib7 8824 30 : : : cord-005453-4057qib7 8824 31 An an DT cord-005453-4057qib7 8824 32 outcome outcome NN cord-005453-4057qib7 8824 33 analysis analysis NN cord-005453-4057qib7 8824 34 on on IN cord-005453-4057qib7 8824 35 behalf behalf NN cord-005453-4057qib7 8824 36 of of IN cord-005453-4057qib7 8824 37 IDWP IDWP NNP cord-005453-4057qib7 8824 38 Background Background NNP cord-005453-4057qib7 8824 39 : : : cord-005453-4057qib7 8824 40 To to TO cord-005453-4057qib7 8824 41 assess assess VB cord-005453-4057qib7 8824 42 the the DT cord-005453-4057qib7 8824 43 incidence incidence NN cord-005453-4057qib7 8824 44 of of IN cord-005453-4057qib7 8824 45 , , , cord-005453-4057qib7 8824 46 and and CC cord-005453-4057qib7 8824 47 risk risk NN cord-005453-4057qib7 8824 48 factors factor NNS cord-005453-4057qib7 8824 49 for for IN cord-005453-4057qib7 8824 50 , , , cord-005453-4057qib7 8824 51 Candida Candida NNP cord-005453-4057qib7 8824 52 infection infection NN cord-005453-4057qib7 8824 53 in in IN cord-005453-4057qib7 8824 54 the the DT cord-005453-4057qib7 8824 55 first first JJ cord-005453-4057qib7 8824 56 100 100 CD cord-005453-4057qib7 8824 57 days day NNS cord-005453-4057qib7 8824 58 post post NN cord-005453-4057qib7 8824 59 - - JJ cord-005453-4057qib7 8824 60 allogeneic allogeneic JJ cord-005453-4057qib7 8824 61 hematopoietic hematopoietic JJ cord-005453-4057qib7 8824 62 stem stem NN cord-005453-4057qib7 8824 63 cell cell NN cord-005453-4057qib7 8824 64 transplantation transplantation NN cord-005453-4057qib7 8824 65 ( ( -LRB- cord-005453-4057qib7 8824 66 HSCT HSCT NNP cord-005453-4057qib7 8824 67 ) ) -RRB- cord-005453-4057qib7 8824 68 and and CC cord-005453-4057qib7 8824 69 the the DT cord-005453-4057qib7 8824 70 impact impact NN cord-005453-4057qib7 8824 71 on on IN cord-005453-4057qib7 8824 72 long long JJ cord-005453-4057qib7 8824 73 - - HYPH cord-005453-4057qib7 8824 74 term term NN cord-005453-4057qib7 8824 75 survival survival NN cord-005453-4057qib7 8824 76 . . . cord-005453-4057qib7 8825 1 Methods method NNS cord-005453-4057qib7 8825 2 : : : cord-005453-4057qib7 8826 1 Outcome outcome NN cord-005453-4057qib7 8826 2 analysis analysis NN cord-005453-4057qib7 8826 3 of of IN cord-005453-4057qib7 8826 4 50,188 50,188 CD cord-005453-4057qib7 8826 5 patients patient NNS cord-005453-4057qib7 8826 6 , , , cord-005453-4057qib7 8826 7 61 61 CD cord-005453-4057qib7 8826 8 % % NN cord-005453-4057qib7 8826 9 male male JJ cord-005453-4057qib7 8826 10 , , , cord-005453-4057qib7 8826 11 median median JJ cord-005453-4057qib7 8826 12 age age NN cord-005453-4057qib7 8826 13 46 46 CD cord-005453-4057qib7 8826 14 years year NNS cord-005453-4057qib7 8826 15 ( ( -LRB- cord-005453-4057qib7 8826 16 range range VBP cord-005453-4057qib7 8826 17 0 0 CD cord-005453-4057qib7 8826 18 - - SYM cord-005453-4057qib7 8826 19 80 80 CD cord-005453-4057qib7 8826 20 ) ) -RRB- cord-005453-4057qib7 8826 21 , , , cord-005453-4057qib7 8826 22 with with IN cord-005453-4057qib7 8826 23 diagnosis diagnosis NN cord-005453-4057qib7 8826 24 of of IN cord-005453-4057qib7 8826 25 hemoglobinopathies hemoglobinopathy NNS cord-005453-4057qib7 8826 26 in in IN cord-005453-4057qib7 8826 27 3176 3176 CD cord-005453-4057qib7 8826 28 ( ( -LRB- cord-005453-4057qib7 8826 29 6.3 6.3 CD cord-005453-4057qib7 8826 30 % % NN cord-005453-4057qib7 8826 31 ) ) -RRB- cord-005453-4057qib7 8826 32 , , , cord-005453-4057qib7 8826 33 bone bone NN cord-005453-4057qib7 8826 34 marrow marrow NN cord-005453-4057qib7 8826 35 failure failure NN cord-005453-4057qib7 8826 36 in in IN cord-005453-4057qib7 8826 37 7626 7626 CD cord-005453-4057qib7 8826 38 ( ( -LRB- cord-005453-4057qib7 8826 39 15.2 15.2 CD cord-005453-4057qib7 8826 40 % % NN cord-005453-4057qib7 8826 41 ) ) -RRB- cord-005453-4057qib7 8826 42 , , , cord-005453-4057qib7 8826 43 lymphoma lymphoma NN cord-005453-4057qib7 8826 44 in in IN cord-005453-4057qib7 8826 45 17743 17743 CD cord-005453-4057qib7 8826 46 ( ( -LRB- cord-005453-4057qib7 8826 47 35.4 35.4 CD cord-005453-4057qib7 8826 48 % % NN cord-005453-4057qib7 8826 49 ) ) -RRB- cord-005453-4057qib7 8826 50 and and CC cord-005453-4057qib7 8826 51 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 8826 52 / / SYM cord-005453-4057qib7 8826 53 myeloproliferative myeloproliferative JJ cord-005453-4057qib7 8826 54 disesases disesase NNS cord-005453-4057qib7 8826 55 in in IN cord-005453-4057qib7 8826 56 21643 21643 CD cord-005453-4057qib7 8826 57 ( ( -LRB- cord-005453-4057qib7 8826 58 43.1 43.1 CD cord-005453-4057qib7 8826 59 % % NN cord-005453-4057qib7 8826 60 ) ) -RRB- cord-005453-4057qib7 8826 61 patients patient NNS cord-005453-4057qib7 8826 62 who who WP cord-005453-4057qib7 8826 63 underwent undergo VBD cord-005453-4057qib7 8826 64 HSCT HSCT NNP cord-005453-4057qib7 8826 65 from from IN cord-005453-4057qib7 8826 66 2000 2000 CD cord-005453-4057qib7 8826 67 to to IN cord-005453-4057qib7 8826 68 2015 2015 CD cord-005453-4057qib7 8826 69 : : : cord-005453-4057qib7 8826 70 420 420 CD cord-005453-4057qib7 8826 71 with with IN cord-005453-4057qib7 8826 72 candidemia candidemia NN cord-005453-4057qib7 8826 73 by by IN cord-005453-4057qib7 8826 74 day day NN cord-005453-4057qib7 8826 75 + + SYM cord-005453-4057qib7 8826 76 100 100 CD cord-005453-4057qib7 8826 77 , , , cord-005453-4057qib7 8826 78 and and CC cord-005453-4057qib7 8826 79 49,768 49,768 CD cord-005453-4057qib7 8826 80 without without IN cord-005453-4057qib7 8826 81 candidemia candidemia NN cord-005453-4057qib7 8826 82 . . . cord-005453-4057qib7 8827 1 The the DT cord-005453-4057qib7 8827 2 incidence incidence NN cord-005453-4057qib7 8827 3 of of IN cord-005453-4057qib7 8827 4 100-day 100-day CD cord-005453-4057qib7 8827 5 candidemia candidemia NN cord-005453-4057qib7 8827 6 was be VBD cord-005453-4057qib7 8827 7 estimated estimate VBN cord-005453-4057qib7 8827 8 by by IN cord-005453-4057qib7 8827 9 using use VBG cord-005453-4057qib7 8827 10 the the DT cord-005453-4057qib7 8827 11 cumulative cumulative JJ cord-005453-4057qib7 8827 12 incidence incidence NN cord-005453-4057qib7 8827 13 method method NN cord-005453-4057qib7 8827 14 . . . cord-005453-4057qib7 8828 1 The the DT cord-005453-4057qib7 8828 2 univariate univariate JJ cord-005453-4057qib7 8828 3 and and CC cord-005453-4057qib7 8828 4 multivariate multivariate JJ cord-005453-4057qib7 8828 5 risk risk NN cord-005453-4057qib7 8828 6 factor factor NN cord-005453-4057qib7 8828 7 analysis analysis NN cord-005453-4057qib7 8828 8 for for IN cord-005453-4057qib7 8828 9 100-day 100-day JJ cord-005453-4057qib7 8828 10 candidemia candidemia NN cord-005453-4057qib7 8828 11 was be VBD cord-005453-4057qib7 8828 12 performed perform VBN cord-005453-4057qib7 8828 13 with with IN cord-005453-4057qib7 8828 14 the the DT cord-005453-4057qib7 8828 15 cause cause NN cord-005453-4057qib7 8828 16 - - HYPH cord-005453-4057qib7 8828 17 specific specific JJ cord-005453-4057qib7 8828 18 Cox Cox NNP cord-005453-4057qib7 8828 19 regression regression NN cord-005453-4057qib7 8828 20 model model NN cord-005453-4057qib7 8828 21 . . . cord-005453-4057qib7 8829 1 The the DT cord-005453-4057qib7 8829 2 occurrence occurrence NN cord-005453-4057qib7 8829 3 of of IN cord-005453-4057qib7 8829 4 candidemia candidemia NN cord-005453-4057qib7 8829 5 was be VBD cord-005453-4057qib7 8829 6 analyzed analyze VBN cord-005453-4057qib7 8829 7 as as IN cord-005453-4057qib7 8829 8 a a DT cord-005453-4057qib7 8829 9 timedependent timedependent NN cord-005453-4057qib7 8829 10 covariate covariate NN cord-005453-4057qib7 8829 11 . . . cord-005453-4057qib7 8830 1 The the DT cord-005453-4057qib7 8830 2 overall overall JJ cord-005453-4057qib7 8830 3 survival survival NN cord-005453-4057qib7 8830 4 and and CC cord-005453-4057qib7 8830 5 non non JJ cord-005453-4057qib7 8830 6 - - JJ cord-005453-4057qib7 8830 7 relapse relapse JJ cord-005453-4057qib7 8830 8 mortality mortality NN cord-005453-4057qib7 8830 9 after after IN cord-005453-4057qib7 8830 10 day day NN cord-005453-4057qib7 8830 11 +100 +100 NNS cord-005453-4057qib7 8830 12 were be VBD cord-005453-4057qib7 8830 13 assessed assess VBN cord-005453-4057qib7 8830 14 in in IN cord-005453-4057qib7 8830 15 a a DT cord-005453-4057qib7 8830 16 land land NN cord-005453-4057qib7 8830 17 - - HYPH cord-005453-4057qib7 8830 18 mark mark NN cord-005453-4057qib7 8830 19 setting setting NN cord-005453-4057qib7 8830 20 , , , cord-005453-4057qib7 8830 21 this this DT cord-005453-4057qib7 8830 22 analysis analysis NN cord-005453-4057qib7 8830 23 was be VBD cord-005453-4057qib7 8830 24 restricted restrict VBN cord-005453-4057qib7 8830 25 to to IN cord-005453-4057qib7 8830 26 patients patient NNS cord-005453-4057qib7 8830 27 surviving survive VBG cord-005453-4057qib7 8830 28 to to IN cord-005453-4057qib7 8830 29 day day NN cord-005453-4057qib7 8830 30 +100 +100 NNP cord-005453-4057qib7 8830 31 post post NN cord-005453-4057qib7 8830 32 transplant transplant NN cord-005453-4057qib7 8830 33 . . . cord-005453-4057qib7 8831 1 [ [ -LRB- cord-005453-4057qib7 8831 2 [ [ -LRB- cord-005453-4057qib7 8831 3 P393 P393 NNP cord-005453-4057qib7 8831 4 Image image NN cord-005453-4057qib7 8831 5 ] ] -RRB- cord-005453-4057qib7 8831 6 1 1 CD cord-005453-4057qib7 8831 7 . . . cord-005453-4057qib7 8832 1 Figure figure NN cord-005453-4057qib7 8832 2 1a 1a CD cord-005453-4057qib7 8832 3 -1b -1b . cord-005453-4057qib7 8833 1 ] ] -RRB- cord-005453-4057qib7 8833 2 Results result NNS cord-005453-4057qib7 8833 3 : : : cord-005453-4057qib7 8834 1 The the DT cord-005453-4057qib7 8834 2 incidence incidence NN cord-005453-4057qib7 8834 3 of of IN cord-005453-4057qib7 8834 4 candidemia candidemia NN cord-005453-4057qib7 8834 5 by by IN cord-005453-4057qib7 8834 6 day day NN cord-005453-4057qib7 8834 7 +100 +100 NNP cord-005453-4057qib7 8834 8 was be VBD cord-005453-4057qib7 8834 9 0.85 0.85 CD cord-005453-4057qib7 8834 10 % % NN cord-005453-4057qib7 8834 11 ( ( -LRB- cord-005453-4057qib7 8834 12 95 95 CD cord-005453-4057qib7 8834 13 % % NN cord-005453-4057qib7 8834 14 C.I. C.I. NNP cord-005453-4057qib7 8834 15 0.77 0.77 CD cord-005453-4057qib7 8834 16 - - HYPH cord-005453-4057qib7 8834 17 0.93 0.93 CD cord-005453-4057qib7 8834 18 ) ) -RRB- cord-005453-4057qib7 8834 19 ( ( -LRB- cord-005453-4057qib7 8834 20 420/50,188 420/50,188 CD cord-005453-4057qib7 8834 21 ) ) -RRB- cord-005453-4057qib7 8834 22 and and CC cord-005453-4057qib7 8834 23 occurred occur VBD cord-005453-4057qib7 8834 24 at at IN cord-005453-4057qib7 8834 25 a a DT cord-005453-4057qib7 8834 26 median median NN cord-005453-4057qib7 8834 27 of of IN cord-005453-4057qib7 8834 28 17 17 CD cord-005453-4057qib7 8834 29 days day NNS cord-005453-4057qib7 8834 30 post post NN cord-005453-4057qib7 8834 31 - - JJ cord-005453-4057qib7 8834 32 HSCT hsct JJ cord-005453-4057qib7 8834 33 ( ( -LRB- cord-005453-4057qib7 8834 34 range range NN cord-005453-4057qib7 8834 35 -7 -7 NNP cord-005453-4057qib7 8834 36 - - HYPH cord-005453-4057qib7 8834 37 100 100 CD cord-005453-4057qib7 8834 38 ) ) -RRB- cord-005453-4057qib7 8834 39 . . . cord-005453-4057qib7 8835 1 Considering consider VBG cord-005453-4057qib7 8835 2 the the DT cord-005453-4057qib7 8835 3 candidemia candidemia NN cord-005453-4057qib7 8835 4 within within IN cord-005453-4057qib7 8835 5 100-day 100-day CD cord-005453-4057qib7 8835 6 from from IN cord-005453-4057qib7 8835 7 HSCT HSCT NNP cord-005453-4057qib7 8835 8 as as IN cord-005453-4057qib7 8835 9 a a DT cord-005453-4057qib7 8835 10 time time NN cord-005453-4057qib7 8835 11 dependent dependent JJ cord-005453-4057qib7 8835 12 covariate covariate NN cord-005453-4057qib7 8835 13 , , , cord-005453-4057qib7 8835 14 a a DT cord-005453-4057qib7 8835 15 higher high JJR cord-005453-4057qib7 8835 16 100-day 100-day JJ cord-005453-4057qib7 8835 17 non non JJ cord-005453-4057qib7 8835 18 - - JJ cord-005453-4057qib7 8835 19 relapsemortality relapsemortality JJ cord-005453-4057qib7 8835 20 ( ( -LRB- cord-005453-4057qib7 8835 21 NRM NRM NNP cord-005453-4057qib7 8835 22 ) ) -RRB- cord-005453-4057qib7 8835 23 ( ( -LRB- cord-005453-4057qib7 8835 24 HR HR NNP cord-005453-4057qib7 8835 25 3.47 3.47 CD cord-005453-4057qib7 8835 26 ( ( -LRB- cord-005453-4057qib7 8835 27 2.75 2.75 CD cord-005453-4057qib7 8835 28 - - SYM cord-005453-4057qib7 8835 29 4.38 4.38 CD cord-005453-4057qib7 8835 30 ) ) -RRB- cord-005453-4057qib7 8835 31 , , , cord-005453-4057qib7 8835 32 p p NN cord-005453-4057qib7 8835 33 < < XX cord-005453-4057qib7 8835 34 0.0001 0.0001 CD cord-005453-4057qib7 8835 35 ) ) -RRB- cord-005453-4057qib7 8835 36 , , , cord-005453-4057qib7 8835 37 and and CC cord-005453-4057qib7 8835 38 a a DT cord-005453-4057qib7 8835 39 lower low JJR cord-005453-4057qib7 8835 40 100-day 100-day JJ cord-005453-4057qib7 8835 41 overall overall JJ cord-005453-4057qib7 8835 42 - - HYPH cord-005453-4057qib7 8835 43 survival survival NN cord-005453-4057qib7 8835 44 ( ( -LRB- cord-005453-4057qib7 8835 45 OS OS NNP cord-005453-4057qib7 8835 46 ) ) -RRB- cord-005453-4057qib7 8836 1 ( ( -LRB- cord-005453-4057qib7 8836 2 HR HR NNP cord-005453-4057qib7 8836 3 3.21 3.21 CD cord-005453-4057qib7 8836 4 , , , cord-005453-4057qib7 8836 5 95 95 CD cord-005453-4057qib7 8836 6 % % NN cord-005453-4057qib7 8836 7 CI CI NNP cord-005453-4057qib7 8836 8 2.67 2.67 CD cord-005453-4057qib7 8836 9 - - HYPH cord-005453-4057qib7 8836 10 3.85 3.85 CD cord-005453-4057qib7 8836 11 ) ) -RRB- cord-005453-4057qib7 8836 12 , , , cord-005453-4057qib7 8836 13 p p NN cord-005453-4057qib7 8836 14 < < XX cord-005453-4057qib7 8836 15 0.0001 0.0001 CD cord-005453-4057qib7 8836 16 ) ) -RRB- cord-005453-4057qib7 8836 17 were be VBD cord-005453-4057qib7 8836 18 obtained obtain VBN cord-005453-4057qib7 8836 19 from from IN cord-005453-4057qib7 8836 20 the the DT cord-005453-4057qib7 8836 21 Cox Cox NNP cord-005453-4057qib7 8836 22 model model NN cord-005453-4057qib7 8836 23 for for IN cord-005453-4057qib7 8836 24 patients patient NNS cord-005453-4057qib7 8836 25 with with IN cord-005453-4057qib7 8836 26 candidemia candidemia NN cord-005453-4057qib7 8836 27 . . . cord-005453-4057qib7 8837 1 Factors factor NNS cord-005453-4057qib7 8837 2 significantly significantly RB cord-005453-4057qib7 8837 3 associated associate VBD cord-005453-4057qib7 8837 4 with with IN cord-005453-4057qib7 8837 5 candidemia candidemia NN cord-005453-4057qib7 8837 6 occurrence occurrence NN cord-005453-4057qib7 8837 7 in in IN cord-005453-4057qib7 8837 8 the the DT cord-005453-4057qib7 8837 9 multivariate multivariate JJ cord-005453-4057qib7 8837 10 analysis analysis NN cord-005453-4057qib7 8837 11 were be VBD cord-005453-4057qib7 8837 12 : : : cord-005453-4057qib7 8837 13 gender gender NN cord-005453-4057qib7 8837 14 female female NN cord-005453-4057qib7 8837 15 , , , cord-005453-4057qib7 8837 16 increased increase VBN cord-005453-4057qib7 8837 17 age age NN cord-005453-4057qib7 8837 18 at at IN cord-005453-4057qib7 8837 19 HSCT HSCT NNP cord-005453-4057qib7 8837 20 , , , cord-005453-4057qib7 8837 21 bone bone NN cord-005453-4057qib7 8837 22 marrow marrow NN cord-005453-4057qib7 8837 23 failure failure NN cord-005453-4057qib7 8837 24 , , , cord-005453-4057qib7 8837 25 lymphoma lymphoma NN cord-005453-4057qib7 8837 26 or or CC cord-005453-4057qib7 8837 27 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 8837 28 / / SYM cord-005453-4057qib7 8837 29 myeloproliferative myeloproliferative JJ cord-005453-4057qib7 8837 30 diagnosis diagnosis NN cord-005453-4057qib7 8837 31 , , , cord-005453-4057qib7 8837 32 bone bone NN cord-005453-4057qib7 8837 33 marrow marrow NN cord-005453-4057qib7 8837 34 or or CC cord-005453-4057qib7 8837 35 cord cord NN cord-005453-4057qib7 8837 36 blood blood NN cord-005453-4057qib7 8837 37 stem stem NN cord-005453-4057qib7 8837 38 cell cell NN cord-005453-4057qib7 8837 39 source source NN cord-005453-4057qib7 8837 40 , , , cord-005453-4057qib7 8837 41 T t NN cord-005453-4057qib7 8837 42 - - HYPH cord-005453-4057qib7 8837 43 cell cell NN cord-005453-4057qib7 8837 44 depletion depletion NN cord-005453-4057qib7 8837 45 , , , cord-005453-4057qib7 8837 46 less less CC cord-005453-4057qib7 8837 47 recent recent JJ cord-005453-4057qib7 8837 48 year year NN cord-005453-4057qib7 8837 49 of of IN cord-005453-4057qib7 8837 50 HSCT HSCT NNP cord-005453-4057qib7 8837 51 . . . cord-005453-4057qib7 8838 1 Among among IN cord-005453-4057qib7 8838 2 patients patient NNS cord-005453-4057qib7 8838 3 alive alive JJ cord-005453-4057qib7 8838 4 at at IN cord-005453-4057qib7 8838 5 day day NN cord-005453-4057qib7 8838 6 + + CC cord-005453-4057qib7 8838 7 100 100 CD cord-005453-4057qib7 8838 8 , , , cord-005453-4057qib7 8838 9 the the DT cord-005453-4057qib7 8838 10 5-year 5-year CD cord-005453-4057qib7 8838 11 NRM NRM NNP cord-005453-4057qib7 8838 12 and and CC cord-005453-4057qib7 8838 13 OS OS NNP cord-005453-4057qib7 8838 14 with with IN cord-005453-4057qib7 8838 15 and and CC cord-005453-4057qib7 8838 16 without without IN cord-005453-4057qib7 8838 17 candidemia candidemia NN cord-005453-4057qib7 8838 18 were be VBD cord-005453-4057qib7 8838 19 28.2 28.2 CD cord-005453-4057qib7 8838 20 % % NN cord-005453-4057qib7 8838 21 vs. vs. IN cord-005453-4057qib7 8838 22 18.8 18.8 CD cord-005453-4057qib7 8838 23 % % NN cord-005453-4057qib7 8838 24 , , , cord-005453-4057qib7 8838 25 p p NN cord-005453-4057qib7 8838 26 < < XX cord-005453-4057qib7 8838 27 0.0001 0.0001 CD cord-005453-4057qib7 8838 28 , , , cord-005453-4057qib7 8838 29 and and CC cord-005453-4057qib7 8838 30 50.5 50.5 CD cord-005453-4057qib7 8838 31 % % NN cord-005453-4057qib7 8838 32 vs. vs. IN cord-005453-4057qib7 8838 33 60.7 60.7 CD cord-005453-4057qib7 8838 34 % % NN cord-005453-4057qib7 8838 35 , , , cord-005453-4057qib7 8838 36 p p NN cord-005453-4057qib7 8838 37 < < XX cord-005453-4057qib7 8838 38 0.0001 0.0001 CD cord-005453-4057qib7 8838 39 , , , cord-005453-4057qib7 8838 40 respectively respectively RB cord-005453-4057qib7 8838 41 , , , cord-005453-4057qib7 8838 42 after after IN cord-005453-4057qib7 8838 43 a a DT cord-005453-4057qib7 8838 44 median median JJ cord-005453-4057qib7 8838 45 follow follow NN cord-005453-4057qib7 8838 46 - - HYPH cord-005453-4057qib7 8838 47 up up NN cord-005453-4057qib7 8838 48 of of IN cord-005453-4057qib7 8838 49 4.3 4.3 CD cord-005453-4057qib7 8838 50 years year NNS cord-005453-4057qib7 8838 51 ( ( -LRB- cord-005453-4057qib7 8838 52 95 95 CD cord-005453-4057qib7 8838 53 % % NN cord-005453-4057qib7 8838 54 CI CI NNP cord-005453-4057qib7 8838 55 4.3 4.3 CD cord-005453-4057qib7 8838 56 - - SYM cord-005453-4057qib7 8838 57 4.4 4.4 CD cord-005453-4057qib7 8838 58 ) ) -RRB- cord-005453-4057qib7 8839 1 ( ( -LRB- cord-005453-4057qib7 8839 2 Figure figure NN cord-005453-4057qib7 8839 3 1 1 CD cord-005453-4057qib7 8839 4 ) ) -RRB- cord-005453-4057qib7 8839 5 . . . cord-005453-4057qib7 8840 1 In in IN cord-005453-4057qib7 8840 2 multivariate multivariate JJ cord-005453-4057qib7 8840 3 analysis analysis NN cord-005453-4057qib7 8840 4 , , , cord-005453-4057qib7 8840 5 the the DT cord-005453-4057qib7 8840 6 occurrence occurrence NN cord-005453-4057qib7 8840 7 of of IN cord-005453-4057qib7 8840 8 a a DT cord-005453-4057qib7 8840 9 candidemia candidemia NN cord-005453-4057qib7 8840 10 episode episode NN cord-005453-4057qib7 8840 11 within within IN cord-005453-4057qib7 8840 12 day day NN cord-005453-4057qib7 8840 13 + + CC cord-005453-4057qib7 8840 14 100 100 CD cord-005453-4057qib7 8840 15 was be VBD cord-005453-4057qib7 8840 16 an an DT cord-005453-4057qib7 8840 17 independent independent JJ cord-005453-4057qib7 8840 18 risk risk NN cord-005453-4057qib7 8840 19 factor factor NN cord-005453-4057qib7 8840 20 for for IN cord-005453-4057qib7 8840 21 higher high JJR cord-005453-4057qib7 8840 22 NRM NRM NNP cord-005453-4057qib7 8840 23 , , , cord-005453-4057qib7 8840 24 HR HR NNP cord-005453-4057qib7 8840 25 1.52 1.52 CD cord-005453-4057qib7 8840 26 ( ( -LRB- cord-005453-4057qib7 8840 27 1.18 1.18 CD cord-005453-4057qib7 8840 28 - - SYM cord-005453-4057qib7 8840 29 1.97 1.97 CD cord-005453-4057qib7 8840 30 ) ) -RRB- cord-005453-4057qib7 8840 31 , , , cord-005453-4057qib7 8840 32 p=0.0013 p=0.0013 NNP cord-005453-4057qib7 8840 33 , , , cord-005453-4057qib7 8840 34 and and CC cord-005453-4057qib7 8840 35 lower low JJR cord-005453-4057qib7 8840 36 OS OS NNP cord-005453-4057qib7 8840 37 , , , cord-005453-4057qib7 8840 38 HR hr NN cord-005453-4057qib7 8840 39 1.30 1.30 CD cord-005453-4057qib7 8840 40 ( ( -LRB- cord-005453-4057qib7 8840 41 1.08 1.08 CD cord-005453-4057qib7 8840 42 - - SYM cord-005453-4057qib7 8840 43 1.57 1.57 CD cord-005453-4057qib7 8840 44 ) ) -RRB- cord-005453-4057qib7 8840 45 , , , cord-005453-4057qib7 8840 46 p=0.0061 p=0.0061 NNS cord-005453-4057qib7 8840 47 . . . cord-005453-4057qib7 8841 1 Conclusions conclusion NNS cord-005453-4057qib7 8841 2 : : : cord-005453-4057qib7 8841 3 despite despite IN cord-005453-4057qib7 8841 4 the the DT cord-005453-4057qib7 8841 5 general general JJ cord-005453-4057qib7 8841 6 improvements improvement NNS cord-005453-4057qib7 8841 7 in in IN cord-005453-4057qib7 8841 8 prophylaxis prophylaxis NN cord-005453-4057qib7 8841 9 and and CC cord-005453-4057qib7 8841 10 treatment treatment NN cord-005453-4057qib7 8841 11 , , , cord-005453-4057qib7 8841 12 the the DT cord-005453-4057qib7 8841 13 occurrence occurrence NN cord-005453-4057qib7 8841 14 of of IN cord-005453-4057qib7 8841 15 early early JJ cord-005453-4057qib7 8841 16 post post JJ cord-005453-4057qib7 8841 17 - - JJ cord-005453-4057qib7 8841 18 HSCT hsct JJ cord-005453-4057qib7 8841 19 candidemia candidemia NN cord-005453-4057qib7 8841 20 had have VBD cord-005453-4057qib7 8841 21 a a DT cord-005453-4057qib7 8841 22 negative negative JJ cord-005453-4057qib7 8841 23 impact impact NN cord-005453-4057qib7 8841 24 on on IN cord-005453-4057qib7 8841 25 transplant transplant NN cord-005453-4057qib7 8841 26 outcome outcome NN cord-005453-4057qib7 8841 27 as as IN cord-005453-4057qib7 8841 28 showed show VBD cord-005453-4057qib7 8841 29 previously previously RB cord-005453-4057qib7 8841 30 in in IN cord-005453-4057qib7 8841 31 leukemic leukemic JJ cord-005453-4057qib7 8841 32 patients patient NNS cord-005453-4057qib7 8841 33 . . . cord-005453-4057qib7 8842 1 Abstract Abstract NNP cord-005453-4057qib7 8842 2 already already RB cord-005453-4057qib7 8842 3 published publish VBN cord-005453-4057qib7 8842 4 . . . cord-005453-4057qib7 8843 1 Carbapenem carbapenem NN cord-005453-4057qib7 8843 2 - - HYPH cord-005453-4057qib7 8843 3 resistant resistant JJ cord-005453-4057qib7 8843 4 enterobacteriaceae enterobacteriaceae NNS cord-005453-4057qib7 8843 5 colonizationimportance colonizationimportance NN cord-005453-4057qib7 8843 6 in in IN cord-005453-4057qib7 8843 7 the the DT cord-005453-4057qib7 8843 8 risk risk NN cord-005453-4057qib7 8843 9 of of IN cord-005453-4057qib7 8843 10 CRE cre NN cord-005453-4057qib7 8843 11 bacteremia bacteremia NN cord-005453-4057qib7 8843 12 and and CC cord-005453-4057qib7 8843 13 mortality mortality NN cord-005453-4057qib7 8843 14 in in IN cord-005453-4057qib7 8843 15 stem stem NN cord-005453-4057qib7 8843 16 cell cell NN cord-005453-4057qib7 8843 17 transplant transplant NN cord-005453-4057qib7 8843 18 ( ( -LRB- cord-005453-4057qib7 8843 19 HSCT HSCT NNP cord-005453-4057qib7 8843 20 ) ) -RRB- cord-005453-4057qib7 8843 21 and and CC cord-005453-4057qib7 8843 22 acute acute JJ cord-005453-4057qib7 8843 23 leukemia leukemia NN cord-005453-4057qib7 8843 24 patients patient NNS cord-005453-4057qib7 8843 25 Marcia Marcia NNP cord-005453-4057qib7 8843 26 Garnica Garnica NNP cord-005453-4057qib7 8843 27 1,2 1,2 CD cord-005453-4057qib7 8843 28 , , , cord-005453-4057qib7 8843 29 Marco Marco NNP cord-005453-4057qib7 8843 30 A A NNP cord-005453-4057qib7 8843 31 F F NNP cord-005453-4057qib7 8843 32 Bellizze Bellizze NNP cord-005453-4057qib7 8843 33 1 1 CD cord-005453-4057qib7 8843 34 , , , cord-005453-4057qib7 8843 35 Priscila Priscila NNP cord-005453-4057qib7 8843 36 G G NNP cord-005453-4057qib7 8843 37 A a NN cord-005453-4057qib7 8843 38 de de FW cord-005453-4057qib7 8843 39 Jesus Jesus NNP cord-005453-4057qib7 8843 40 1 1 CD cord-005453-4057qib7 8843 41 , , , cord-005453-4057qib7 8843 42 Rafaela Rafaela NNP cord-005453-4057qib7 8843 43 R r NN cord-005453-4057qib7 8843 44 C c NN cord-005453-4057qib7 8843 45 Gomes Gomes NNP cord-005453-4057qib7 8843 46 1 1 CD cord-005453-4057qib7 8843 47 , , , cord-005453-4057qib7 8843 48 Filipe Filipe NNP cord-005453-4057qib7 8843 49 M M NNP cord-005453-4057qib7 8843 50 Akamine Akamine NNP cord-005453-4057qib7 8843 51 1 1 CD cord-005453-4057qib7 8843 52 , , , cord-005453-4057qib7 8843 53 Alan Alan NNP cord-005453-4057qib7 8843 54 J J NNP cord-005453-4057qib7 8843 55 Marçal Marçal NNP cord-005453-4057qib7 8843 56 1 1 CD cord-005453-4057qib7 8843 57 , , , cord-005453-4057qib7 8843 58 Luzinete Luzinete NNP cord-005453-4057qib7 8843 59 CO CO NNP cord-005453-4057qib7 8843 60 Rangel Rangel NNP cord-005453-4057qib7 8843 61 2 2 CD cord-005453-4057qib7 8844 1 , , , cord-005453-4057qib7 8844 2 Andreia Andreia NNP cord-005453-4057qib7 8844 3 Assis Assis NNP cord-005453-4057qib7 8844 4 2 2 CD cord-005453-4057qib7 8844 5 , , , cord-005453-4057qib7 8844 6 Marcia Marcia NNP cord-005453-4057qib7 8844 7 Rejane Rejane NNP cord-005453-4057qib7 8844 8 Valentim Valentim NNP cord-005453-4057qib7 8844 9 2 2 CD cord-005453-4057qib7 8844 10 , , , cord-005453-4057qib7 8844 11 Angelo Angelo NNP cord-005453-4057qib7 8844 12 Maiolino Maiolino NNP cord-005453-4057qib7 8844 13 1 1 CD cord-005453-4057qib7 8844 14 Background Background NNP cord-005453-4057qib7 8844 15 : : : cord-005453-4057qib7 8845 1 Spread Spread VBN cord-005453-4057qib7 8845 2 of of IN cord-005453-4057qib7 8845 3 infections infection NNS cord-005453-4057qib7 8845 4 due due JJ cord-005453-4057qib7 8845 5 to to IN cord-005453-4057qib7 8845 6 Carbapenemresistant Carbapenemresistant NNP cord-005453-4057qib7 8845 7 Enterobacteriaceae Enterobacteriaceae NNP cord-005453-4057qib7 8845 8 ( ( -LRB- cord-005453-4057qib7 8845 9 CRE CRE NNP cord-005453-4057qib7 8845 10 ) ) -RRB- cord-005453-4057qib7 8845 11 is be VBZ cord-005453-4057qib7 8845 12 a a DT cord-005453-4057qib7 8845 13 worldwide worldwide JJ cord-005453-4057qib7 8845 14 phenomenon phenomenon NN cord-005453-4057qib7 8845 15 and and CC cord-005453-4057qib7 8845 16 has have VBZ cord-005453-4057qib7 8845 17 been be VBN cord-005453-4057qib7 8845 18 associated associate VBN cord-005453-4057qib7 8845 19 with with IN cord-005453-4057qib7 8845 20 high high JJ cord-005453-4057qib7 8845 21 mortality mortality NN cord-005453-4057qib7 8845 22 and and CC cord-005453-4057qib7 8845 23 clinical clinical JJ cord-005453-4057qib7 8845 24 complications complication NNS cord-005453-4057qib7 8845 25 . . . cord-005453-4057qib7 8846 1 Gut gut NN cord-005453-4057qib7 8846 2 translocation translocation NN cord-005453-4057qib7 8846 3 is be VBZ cord-005453-4057qib7 8846 4 the the DT cord-005453-4057qib7 8846 5 most most RBS cord-005453-4057qib7 8846 6 important important JJ cord-005453-4057qib7 8846 7 portal portal NN cord-005453-4057qib7 8846 8 of of IN cord-005453-4057qib7 8846 9 entry entry NN cord-005453-4057qib7 8846 10 of of IN cord-005453-4057qib7 8846 11 bacteria bacteria NNS cord-005453-4057qib7 8846 12 during during IN cord-005453-4057qib7 8846 13 neutropenia neutropenia NN cord-005453-4057qib7 8846 14 , , , cord-005453-4057qib7 8846 15 and and CC cord-005453-4057qib7 8846 16 CRE CRE NNP cord-005453-4057qib7 8846 17 gut gut NN cord-005453-4057qib7 8846 18 colonization colonization NN cord-005453-4057qib7 8846 19 is be VBZ cord-005453-4057qib7 8846 20 a a DT cord-005453-4057qib7 8846 21 possible possible JJ cord-005453-4057qib7 8846 22 risk risk NN cord-005453-4057qib7 8846 23 factor factor NN cord-005453-4057qib7 8846 24 for for IN cord-005453-4057qib7 8846 25 bacteremia bacteremia NN cord-005453-4057qib7 8846 26 during during IN cord-005453-4057qib7 8846 27 neutropenia neutropenia NN cord-005453-4057qib7 8846 28 . . . cord-005453-4057qib7 8847 1 Goals goal NNS cord-005453-4057qib7 8847 2 : : : cord-005453-4057qib7 8848 1 In in IN cord-005453-4057qib7 8848 2 the the DT cord-005453-4057qib7 8848 3 present present JJ cord-005453-4057qib7 8848 4 study study NN cord-005453-4057qib7 8848 5 , , , cord-005453-4057qib7 8848 6 we -PRON- PRP cord-005453-4057qib7 8848 7 describe describe VBP cord-005453-4057qib7 8848 8 the the DT cord-005453-4057qib7 8848 9 frequencies frequency NNS cord-005453-4057qib7 8848 10 of of IN cord-005453-4057qib7 8848 11 CRE CRE NNP cord-005453-4057qib7 8848 12 colonization colonization NN cord-005453-4057qib7 8848 13 and and CC cord-005453-4057qib7 8848 14 analyzed analyze VBD cord-005453-4057qib7 8848 15 its -PRON- PRP$ cord-005453-4057qib7 8848 16 relationship relationship NN cord-005453-4057qib7 8848 17 with with IN cord-005453-4057qib7 8848 18 development development NN cord-005453-4057qib7 8848 19 of of IN cord-005453-4057qib7 8848 20 CRE cre NN cord-005453-4057qib7 8848 21 bacteremia bacteremia NN cord-005453-4057qib7 8848 22 and and CC cord-005453-4057qib7 8848 23 mortality mortality NN cord-005453-4057qib7 8848 24 in in IN cord-005453-4057qib7 8848 25 two two CD cord-005453-4057qib7 8848 26 different different JJ cord-005453-4057qib7 8848 27 scenarios scenario NNS cord-005453-4057qib7 8848 28 : : : cord-005453-4057qib7 8848 29 stem stem VB cord-005453-4057qib7 8848 30 cell cell NN cord-005453-4057qib7 8848 31 transplant transplant NN cord-005453-4057qib7 8848 32 patients patient NNS cord-005453-4057qib7 8848 33 ( ( -LRB- cord-005453-4057qib7 8848 34 HSCT HSCT NNP cord-005453-4057qib7 8848 35 ) ) -RRB- cord-005453-4057qib7 8848 36 and and CC cord-005453-4057qib7 8848 37 Leukemia Leukemia NNP cord-005453-4057qib7 8848 38 patients patient NNS cord-005453-4057qib7 8848 39 . . . cord-005453-4057qib7 8849 1 Methods method NNS cord-005453-4057qib7 8849 2 : : : cord-005453-4057qib7 8849 3 Prospective prospective JJ cord-005453-4057qib7 8849 4 cohorts cohort NNS cord-005453-4057qib7 8849 5 of of IN cord-005453-4057qib7 8849 6 HSCT HSCT NNP cord-005453-4057qib7 8849 7 ( ( -LRB- cord-005453-4057qib7 8849 8 from from IN cord-005453-4057qib7 8849 9 2012 2012 CD cord-005453-4057qib7 8849 10 to to IN cord-005453-4057qib7 8849 11 2017 2017 CD cord-005453-4057qib7 8849 12 ) ) -RRB- cord-005453-4057qib7 8849 13 and and CC cord-005453-4057qib7 8849 14 Leukemia Leukemia NNP cord-005453-4057qib7 8849 15 patients patient NNS cord-005453-4057qib7 8849 16 ( ( -LRB- cord-005453-4057qib7 8849 17 from from IN cord-005453-4057qib7 8849 18 2016 2016 CD cord-005453-4057qib7 8849 19 to to IN cord-005453-4057qib7 8849 20 2018 2018 CD cord-005453-4057qib7 8849 21 ) ) -RRB- cord-005453-4057qib7 8849 22 . . . cord-005453-4057qib7 8850 1 HSCT HSCT NNP cord-005453-4057qib7 8850 2 patients patient NNS cord-005453-4057qib7 8850 3 were be VBD cord-005453-4057qib7 8850 4 analyzed analyze VBN cord-005453-4057qib7 8850 5 from from IN cord-005453-4057qib7 8850 6 conditioning conditioning NN cord-005453-4057qib7 8850 7 until until IN cord-005453-4057qib7 8850 8 discharge discharge NN cord-005453-4057qib7 8850 9 ( ( -LRB- cord-005453-4057qib7 8850 10 pre pre JJ cord-005453-4057qib7 8850 11 - - JJ cord-005453-4057qib7 8850 12 engraphment engraphment JJ cord-005453-4057qib7 8850 13 phase phase NN cord-005453-4057qib7 8850 14 ) ) -RRB- cord-005453-4057qib7 8850 15 and and CC cord-005453-4057qib7 8850 16 leukemia leukemia NN cord-005453-4057qib7 8850 17 patients patient NNS cord-005453-4057qib7 8850 18 from from IN cord-005453-4057qib7 8850 19 first first JJ cord-005453-4057qib7 8850 20 induction induction NN cord-005453-4057qib7 8850 21 chemotherapy chemotherapy NN cord-005453-4057qib7 8850 22 until until IN cord-005453-4057qib7 8850 23 last last JJ cord-005453-4057qib7 8850 24 intensification intensification NN cord-005453-4057qib7 8850 25 . . . cord-005453-4057qib7 8851 1 If if IN cord-005453-4057qib7 8851 2 an an DT cord-005453-4057qib7 8851 3 HSCT HSCT NNP cord-005453-4057qib7 8851 4 was be VBD cord-005453-4057qib7 8851 5 performed perform VBN cord-005453-4057qib7 8851 6 in in IN cord-005453-4057qib7 8851 7 Leukemia Leukemia NNP cord-005453-4057qib7 8851 8 patient patient NN cord-005453-4057qib7 8851 9 the the DT cord-005453-4057qib7 8851 10 patient patient NN cord-005453-4057qib7 8851 11 was be VBD cord-005453-4057qib7 8851 12 censored censor VBN cord-005453-4057qib7 8851 13 in in IN cord-005453-4057qib7 8851 14 leukemia leukemia NN cord-005453-4057qib7 8851 15 cohort cohort NN cord-005453-4057qib7 8851 16 and and CC cord-005453-4057qib7 8851 17 included include VBD cord-005453-4057qib7 8851 18 in in IN cord-005453-4057qib7 8851 19 HSCT HSCT NNP cord-005453-4057qib7 8851 20 cohort cohort NN cord-005453-4057qib7 8851 21 . . . cord-005453-4057qib7 8852 1 All all DT cord-005453-4057qib7 8852 2 patients patient NNS cord-005453-4057qib7 8852 3 had have VBD cord-005453-4057qib7 8852 4 rectal rectal JJ cord-005453-4057qib7 8852 5 swabs swab NNS cord-005453-4057qib7 8852 6 performed perform VBN cord-005453-4057qib7 8852 7 weekly weekly RB cord-005453-4057qib7 8852 8 during during IN cord-005453-4057qib7 8852 9 hospitalization hospitalization NN cord-005453-4057qib7 8852 10 for for IN cord-005453-4057qib7 8852 11 the the DT cord-005453-4057qib7 8852 12 identification identification NN cord-005453-4057qib7 8852 13 of of IN cord-005453-4057qib7 8852 14 CRE CRE NNP cord-005453-4057qib7 8852 15 colonization colonization NN cord-005453-4057qib7 8852 16 . . . cord-005453-4057qib7 8853 1 Patients patient NNS cord-005453-4057qib7 8853 2 with with IN cord-005453-4057qib7 8853 3 at at RB cord-005453-4057qib7 8853 4 least least RBS cord-005453-4057qib7 8853 5 one one CD cord-005453-4057qib7 8853 6 positive positive JJ cord-005453-4057qib7 8853 7 swab swab NN cord-005453-4057qib7 8853 8 ( ( -LRB- cord-005453-4057qib7 8853 9 CRE CRE NNP cord-005453-4057qib7 8853 10 colonization colonization NN cord-005453-4057qib7 8853 11 group group NN cord-005453-4057qib7 8853 12 ) ) -RRB- cord-005453-4057qib7 8853 13 were be VBD cord-005453-4057qib7 8853 14 compared compare VBN cord-005453-4057qib7 8853 15 to to IN cord-005453-4057qib7 8853 16 patients patient NNS cord-005453-4057qib7 8853 17 with with IN cord-005453-4057qib7 8853 18 no no DT cord-005453-4057qib7 8853 19 documentation documentation NN cord-005453-4057qib7 8853 20 of of IN cord-005453-4057qib7 8853 21 colonization colonization NN cord-005453-4057qib7 8853 22 ( ( -LRB- cord-005453-4057qib7 8853 23 controls control NNS cord-005453-4057qib7 8853 24 ) ) -RRB- cord-005453-4057qib7 8853 25 . . . cord-005453-4057qib7 8854 1 The the DT cord-005453-4057qib7 8854 2 outcomes outcome NNS cord-005453-4057qib7 8854 3 analyzed analyze VBD cord-005453-4057qib7 8854 4 were be VBD cord-005453-4057qib7 8854 5 bacteremia bacteremia NN cord-005453-4057qib7 8854 6 due due IN cord-005453-4057qib7 8854 7 to to IN cord-005453-4057qib7 8854 8 CRE CRE NNP cord-005453-4057qib7 8854 9 , , , cord-005453-4057qib7 8854 10 and and CC cord-005453-4057qib7 8854 11 overall overall JJ cord-005453-4057qib7 8854 12 mortality mortality NN cord-005453-4057qib7 8854 13 . . . cord-005453-4057qib7 8855 1 Results result NNS cord-005453-4057qib7 8855 2 : : : cord-005453-4057qib7 8856 1 There there EX cord-005453-4057qib7 8856 2 were be VBD cord-005453-4057qib7 8856 3 493 493 CD cord-005453-4057qib7 8856 4 HSCT HSCT NNP cord-005453-4057qib7 8856 5 performed perform VBN cord-005453-4057qib7 8856 6 during during IN cord-005453-4057qib7 8856 7 the the DT cord-005453-4057qib7 8856 8 study study NN cord-005453-4057qib7 8856 9 ( ( -LRB- cord-005453-4057qib7 8856 10 408 408 CD cord-005453-4057qib7 8856 11 [ [ -LRB- cord-005453-4057qib7 8856 12 83 83 CD cord-005453-4057qib7 8856 13 % % NN cord-005453-4057qib7 8856 14 ] ] -RRB- cord-005453-4057qib7 8856 15 autologous autologous JJ cord-005453-4057qib7 8856 16 and and CC cord-005453-4057qib7 8856 17 85 85 CD cord-005453-4057qib7 8856 18 [ [ -LRB- cord-005453-4057qib7 8856 19 17 17 CD cord-005453-4057qib7 8856 20 % % NN cord-005453-4057qib7 8856 21 ] ] -RRB- cord-005453-4057qib7 8856 22 allogeneic allogeneic NN cord-005453-4057qib7 8856 23 ) ) -RRB- cord-005453-4057qib7 8856 24 . . . cord-005453-4057qib7 8857 1 Multiple multiple JJ cord-005453-4057qib7 8857 2 myeloma myeloma NN cord-005453-4057qib7 8857 3 and and CC cord-005453-4057qib7 8857 4 Non Non NNP cord-005453-4057qib7 8857 5 - - NNP cord-005453-4057qib7 8857 6 Hodgkin Hodgkin NNP cord-005453-4057qib7 8857 7 Lymphoma Lymphoma NNP cord-005453-4057qib7 8857 8 were be VBD cord-005453-4057qib7 8857 9 the the DT cord-005453-4057qib7 8857 10 most most RBS cord-005453-4057qib7 8857 11 frequent frequent JJ cord-005453-4057qib7 8857 12 baseline baseline JJ cord-005453-4057qib7 8857 13 diseases disease NNS cord-005453-4057qib7 8857 14 ( ( -LRB- cord-005453-4057qib7 8857 15 N=251 N=251 NNP cord-005453-4057qib7 8857 16 ; ; : cord-005453-4057qib7 8857 17 51 51 CD cord-005453-4057qib7 8857 18 % % NN cord-005453-4057qib7 8857 19 , , , cord-005453-4057qib7 8857 20 and and CC cord-005453-4057qib7 8857 21 N n NN cord-005453-4057qib7 8857 22 = = SYM cord-005453-4057qib7 8857 23 88 88 CD cord-005453-4057qib7 8857 24 ; ; : cord-005453-4057qib7 8857 25 18 18 CD cord-005453-4057qib7 8857 26 % % NN cord-005453-4057qib7 8857 27 ) ) -RRB- cord-005453-4057qib7 8857 28 , , , cord-005453-4057qib7 8857 29 respectively respectively RB cord-005453-4057qib7 8857 30 . . . cord-005453-4057qib7 8858 1 CRE CRE NNP cord-005453-4057qib7 8858 2 colonization colonization NN cord-005453-4057qib7 8858 3 was be VBD cord-005453-4057qib7 8858 4 documented document VBN cord-005453-4057qib7 8858 5 in in IN cord-005453-4057qib7 8858 6 10 10 CD cord-005453-4057qib7 8858 7 % % NN cord-005453-4057qib7 8858 8 ( ( -LRB- cord-005453-4057qib7 8858 9 N=50 N=50 NNP cord-005453-4057qib7 8858 10 ) ) -RRB- cord-005453-4057qib7 8858 11 , , , cord-005453-4057qib7 8858 12 and and CC cord-005453-4057qib7 8858 13 it -PRON- PRP cord-005453-4057qib7 8858 14 was be VBD cord-005453-4057qib7 8858 15 more more RBR cord-005453-4057qib7 8858 16 frequent frequent JJ cord-005453-4057qib7 8858 17 among among IN cord-005453-4057qib7 8858 18 Allogeneic Allogeneic NNP cord-005453-4057qib7 8858 19 HSCT HSCT NNP cord-005453-4057qib7 8858 20 and and CC cord-005453-4057qib7 8858 21 Leukemia Leukemia NNP cord-005453-4057qib7 8858 22 patients patient NNS cord-005453-4057qib7 8858 23 ( ( -LRB- cord-005453-4057qib7 8858 24 p p NN cord-005453-4057qib7 8858 25 < < XX cord-005453-4057qib7 8858 26 0.001 0.001 CD cord-005453-4057qib7 8858 27 for for IN cord-005453-4057qib7 8858 28 both both DT cord-005453-4057qib7 8858 29 ) ) -RRB- cord-005453-4057qib7 8858 30 . . . cord-005453-4057qib7 8859 1 CRE CRE NNP cord-005453-4057qib7 8859 2 colonized colonize VBN cord-005453-4057qib7 8859 3 patients patient NNS cord-005453-4057qib7 8859 4 had have VBD cord-005453-4057qib7 8859 5 longer long JJR cord-005453-4057qib7 8859 6 hospitalization hospitalization NN cord-005453-4057qib7 8859 7 ( ( -LRB- cord-005453-4057qib7 8859 8 25 25 CD cord-005453-4057qib7 8859 9 vs. vs. NN cord-005453-4057qib7 8859 10 20 20 CD cord-005453-4057qib7 8859 11 days day NNS cord-005453-4057qib7 8859 12 , , , cord-005453-4057qib7 8859 13 p p NN cord-005453-4057qib7 8859 14 < < XX cord-005453-4057qib7 8859 15 0,001 0,001 CD cord-005453-4057qib7 8859 16 ) ) -RRB- cord-005453-4057qib7 8859 17 , , , cord-005453-4057qib7 8859 18 higher high JJR cord-005453-4057qib7 8859 19 frequency frequency NN cord-005453-4057qib7 8859 20 of of IN cord-005453-4057qib7 8859 21 CRE cre NN cord-005453-4057qib7 8859 22 bacteremia bacteremia NN cord-005453-4057qib7 8859 23 ( ( -LRB- cord-005453-4057qib7 8859 24 6 6 CD cord-005453-4057qib7 8859 25 % % NN cord-005453-4057qib7 8859 26 vs. vs. CC cord-005453-4057qib7 8859 27 0.2 0.2 CD cord-005453-4057qib7 8859 28 % % NN cord-005453-4057qib7 8859 29 ; ; : cord-005453-4057qib7 8859 30 p=0.004 p=0.004 NNP cord-005453-4057qib7 8859 31 ) ) -RRB- cord-005453-4057qib7 8859 32 , , , cord-005453-4057qib7 8859 33 and and CC cord-005453-4057qib7 8859 34 mortality mortality NN cord-005453-4057qib7 8859 35 ( ( -LRB- cord-005453-4057qib7 8859 36 16 16 CD cord-005453-4057qib7 8859 37 % % NN cord-005453-4057qib7 8859 38 vs. vs. CC cord-005453-4057qib7 8859 39 2.4 2.4 CD cord-005453-4057qib7 8859 40 % % NN cord-005453-4057qib7 8859 41 , , , cord-005453-4057qib7 8859 42 p p NN cord-005453-4057qib7 8859 43 < < XX cord-005453-4057qib7 8859 44 0,001 0,001 CD cord-005453-4057qib7 8859 45 ) ) -RRB- cord-005453-4057qib7 8859 46 compared compare VBN cord-005453-4057qib7 8859 47 to to IN cord-005453-4057qib7 8859 48 non non JJ cord-005453-4057qib7 8859 49 - - JJ cord-005453-4057qib7 8859 50 colonized colonize VBN cord-005453-4057qib7 8859 51 HSCT HSCT NNP cord-005453-4057qib7 8859 52 . . . cord-005453-4057qib7 8860 1 Negative negative JJ cord-005453-4057qib7 8860 2 and and CC cord-005453-4057qib7 8860 3 positive positive JJ cord-005453-4057qib7 8860 4 predicted predict VBN cord-005453-4057qib7 8860 5 values value NNS cord-005453-4057qib7 8860 6 for for IN cord-005453-4057qib7 8860 7 CRE cre NN cord-005453-4057qib7 8860 8 bacteremia bacteremia NN cord-005453-4057qib7 8860 9 were be VBD cord-005453-4057qib7 8860 10 6 6 CD cord-005453-4057qib7 8860 11 % % NN cord-005453-4057qib7 8860 12 and and CC cord-005453-4057qib7 8860 13 99 99 CD cord-005453-4057qib7 8860 14 % % NN cord-005453-4057qib7 8860 15 , , , cord-005453-4057qib7 8860 16 respectively respectively RB cord-005453-4057qib7 8860 17 . . . cord-005453-4057qib7 8861 1 Thirty thirty CD cord-005453-4057qib7 8861 2 - - HYPH cord-005453-4057qib7 8861 3 one one CD cord-005453-4057qib7 8861 4 patients patient NNS cord-005453-4057qib7 8861 5 were be VBD cord-005453-4057qib7 8861 6 analyzed analyze VBN cord-005453-4057qib7 8861 7 in in IN cord-005453-4057qib7 8861 8 Leukemia Leukemia NNP cord-005453-4057qib7 8861 9 cohort cohort NN cord-005453-4057qib7 8861 10 , , , cord-005453-4057qib7 8861 11 accounting account VBG cord-005453-4057qib7 8861 12 to to IN cord-005453-4057qib7 8861 13 92 92 CD cord-005453-4057qib7 8861 14 hospitalizations hospitalization NNS cord-005453-4057qib7 8861 15 ( ( -LRB- cord-005453-4057qib7 8861 16 median median JJ cord-005453-4057qib7 8861 17 3 3 CD cord-005453-4057qib7 8861 18 hospitalizations hospitalization NNS cord-005453-4057qib7 8861 19 per per IN cord-005453-4057qib7 8861 20 patient patient NN cord-005453-4057qib7 8861 21 , , , cord-005453-4057qib7 8861 22 ranging range VBG cord-005453-4057qib7 8861 23 from from IN cord-005453-4057qib7 8861 24 1 1 CD cord-005453-4057qib7 8861 25 to to IN cord-005453-4057qib7 8861 26 6 6 CD cord-005453-4057qib7 8861 27 ) ) -RRB- cord-005453-4057qib7 8861 28 . . . cord-005453-4057qib7 8862 1 The the DT cord-005453-4057qib7 8862 2 median median JJ cord-005453-4057qib7 8862 3 age age NN cord-005453-4057qib7 8862 4 was be VBD cord-005453-4057qib7 8862 5 58 58 CD cord-005453-4057qib7 8862 6 years year NNS cord-005453-4057qib7 8862 7 , , , cord-005453-4057qib7 8862 8 and and CC cord-005453-4057qib7 8862 9 90 90 CD cord-005453-4057qib7 8862 10 % % NN cord-005453-4057qib7 8862 11 AML aml NN cord-005453-4057qib7 8862 12 vs. vs. CC cord-005453-4057qib7 8862 13 10 10 CD cord-005453-4057qib7 8862 14 % % NN cord-005453-4057qib7 8862 15 ALL all DT cord-005453-4057qib7 8862 16 . . . cord-005453-4057qib7 8863 1 CRE CRE NNP cord-005453-4057qib7 8863 2 colonization colonization NN cord-005453-4057qib7 8863 3 was be VBD cord-005453-4057qib7 8863 4 documented document VBN cord-005453-4057qib7 8863 5 in in IN cord-005453-4057qib7 8863 6 eight eight CD cord-005453-4057qib7 8863 7 ( ( -LRB- cord-005453-4057qib7 8863 8 26 26 CD cord-005453-4057qib7 8863 9 % % NN cord-005453-4057qib7 8863 10 ) ) -RRB- cord-005453-4057qib7 8863 11 , , , cord-005453-4057qib7 8863 12 with with IN cord-005453-4057qib7 8863 13 a a DT cord-005453-4057qib7 8863 14 median median JJ cord-005453-4057qib7 8863 15 time time NN cord-005453-4057qib7 8863 16 from from IN cord-005453-4057qib7 8863 17 leukemia leukemia NN cord-005453-4057qib7 8863 18 diagnosis diagnosis NN cord-005453-4057qib7 8863 19 and and CC cord-005453-4057qib7 8863 20 colonization colonization NN cord-005453-4057qib7 8863 21 of of IN cord-005453-4057qib7 8863 22 93 93 CD cord-005453-4057qib7 8863 23 days day NNS cord-005453-4057qib7 8863 24 ( ( -LRB- cord-005453-4057qib7 8863 25 9 9 CD cord-005453-4057qib7 8863 26 -503 -503 NN cord-005453-4057qib7 8863 27 days day NNS cord-005453-4057qib7 8863 28 ) ) -RRB- cord-005453-4057qib7 8863 29 . . . cord-005453-4057qib7 8864 1 CRE CRE NNP cord-005453-4057qib7 8864 2 bacteremia bacteremia NN cord-005453-4057qib7 8864 3 was be VBD cord-005453-4057qib7 8864 4 documented document VBN cord-005453-4057qib7 8864 5 only only RB cord-005453-4057qib7 8864 6 in in IN cord-005453-4057qib7 8864 7 colonized colonize VBN cord-005453-4057qib7 8864 8 patients patient NNS cord-005453-4057qib7 8864 9 ( ( -LRB- cord-005453-4057qib7 8864 10 25 25 CD cord-005453-4057qib7 8864 11 % % NN cord-005453-4057qib7 8864 12 vs. vs. IN cord-005453-4057qib7 8864 13 zero zero CD cord-005453-4057qib7 8864 14 ; ; : cord-005453-4057qib7 8864 15 p=0,046 p=0,046 NNP cord-005453-4057qib7 8864 16 ) ) -RRB- cord-005453-4057qib7 8864 17 . . . cord-005453-4057qib7 8865 1 All all DT cord-005453-4057qib7 8865 2 eight eight CD cord-005453-4057qib7 8865 3 colonized colonize VBN cord-005453-4057qib7 8865 4 patients patient NNS cord-005453-4057qib7 8865 5 were be VBD cord-005453-4057qib7 8865 6 submitted submit VBN cord-005453-4057qib7 8865 7 to to IN cord-005453-4057qib7 8865 8 other other JJ cord-005453-4057qib7 8865 9 cycles cycle NNS cord-005453-4057qib7 8865 10 of of IN cord-005453-4057qib7 8865 11 chemotherapy chemotherapy NN cord-005453-4057qib7 8865 12 after after IN cord-005453-4057qib7 8865 13 colonization colonization NN cord-005453-4057qib7 8865 14 , , , cord-005453-4057qib7 8865 15 in in IN cord-005453-4057qib7 8865 16 one one CD cord-005453-4057qib7 8865 17 of of IN cord-005453-4057qib7 8865 18 them -PRON- PRP cord-005453-4057qib7 8865 19 CRE CRE NNP cord-005453-4057qib7 8865 20 bacteremia bacteremia NN cord-005453-4057qib7 8865 21 relapsed relapse VBD cord-005453-4057qib7 8865 22 . . . cord-005453-4057qib7 8866 1 Conclusions conclusion NNS cord-005453-4057qib7 8866 2 : : : cord-005453-4057qib7 8867 1 A a DT cord-005453-4057qib7 8867 2 routine routine JJ cord-005453-4057qib7 8867 3 surveillance surveillance NN cord-005453-4057qib7 8867 4 of of IN cord-005453-4057qib7 8867 5 CRE CRE NNP cord-005453-4057qib7 8867 6 colonization colonization NN cord-005453-4057qib7 8867 7 showed show VBD cord-005453-4057qib7 8867 8 colonization colonization NN cord-005453-4057qib7 8867 9 frequencies frequency NNS cord-005453-4057qib7 8867 10 from from IN cord-005453-4057qib7 8867 11 10 10 CD cord-005453-4057qib7 8867 12 % % NN cord-005453-4057qib7 8867 13 to to IN cord-005453-4057qib7 8867 14 25 25 CD cord-005453-4057qib7 8867 15 % % NN cord-005453-4057qib7 8867 16 in in IN cord-005453-4057qib7 8867 17 HSCT HSCT NNP cord-005453-4057qib7 8867 18 and and CC cord-005453-4057qib7 8867 19 Leukemia Leukemia NNP cord-005453-4057qib7 8867 20 patients patient NNS cord-005453-4057qib7 8867 21 respectively respectively RB cord-005453-4057qib7 8867 22 and and CC cord-005453-4057qib7 8867 23 was be VBD cord-005453-4057qib7 8867 24 effective effective JJ cord-005453-4057qib7 8867 25 to to TO cord-005453-4057qib7 8867 26 stratify stratify VB cord-005453-4057qib7 8867 27 CRE cre NN cord-005453-4057qib7 8867 28 bacteremia bacteremia NN cord-005453-4057qib7 8867 29 risk risk NN cord-005453-4057qib7 8867 30 as as IN cord-005453-4057qib7 8867 31 the the DT cord-005453-4057qib7 8867 32 predictive predictive JJ cord-005453-4057qib7 8867 33 negative negative JJ cord-005453-4057qib7 8867 34 value value NN cord-005453-4057qib7 8867 35 was be VBD cord-005453-4057qib7 8867 36 over over IN cord-005453-4057qib7 8867 37 95 95 CD cord-005453-4057qib7 8867 38 % % NN cord-005453-4057qib7 8867 39 . . . cord-005453-4057qib7 8868 1 Colonization colonization NN cord-005453-4057qib7 8868 2 had have VBD cord-005453-4057qib7 8868 3 association association NN cord-005453-4057qib7 8868 4 with with IN cord-005453-4057qib7 8868 5 CRE CRE NNP cord-005453-4057qib7 8868 6 bacteremia bacteremia NN cord-005453-4057qib7 8868 7 and and CC cord-005453-4057qib7 8868 8 overall overall JJ cord-005453-4057qib7 8868 9 mortality mortality NN cord-005453-4057qib7 8868 10 . . . cord-005453-4057qib7 8869 1 Efforts effort NNS cord-005453-4057qib7 8869 2 to to TO cord-005453-4057qib7 8869 3 minimize minimize VB cord-005453-4057qib7 8869 4 risks risk NNS cord-005453-4057qib7 8869 5 for for IN cord-005453-4057qib7 8869 6 colonization colonization NN cord-005453-4057qib7 8869 7 and and CC cord-005453-4057qib7 8869 8 mortality mortality NN cord-005453-4057qib7 8869 9 are be VBP cord-005453-4057qib7 8869 10 necessary necessary JJ cord-005453-4057qib7 8869 11 . . . cord-005453-4057qib7 8870 1 The the DT cord-005453-4057qib7 8870 2 information information NN cord-005453-4057qib7 8870 3 of of IN cord-005453-4057qib7 8870 4 surveillance surveillance NN cord-005453-4057qib7 8870 5 can can MD cord-005453-4057qib7 8870 6 be be VB cord-005453-4057qib7 8870 7 a a DT cord-005453-4057qib7 8870 8 tool tool NN cord-005453-4057qib7 8870 9 to to TO cord-005453-4057qib7 8870 10 improve improve VB cord-005453-4057qib7 8870 11 adequacy adequacy NN cord-005453-4057qib7 8870 12 in in IN cord-005453-4057qib7 8870 13 empirical empirical JJ cord-005453-4057qib7 8870 14 febrile febrile JJ cord-005453-4057qib7 8870 15 neutropenia neutropenia NN cord-005453-4057qib7 8870 16 therapy therapy NN cord-005453-4057qib7 8870 17 in in IN cord-005453-4057qib7 8870 18 HSCT HSCT NNP cord-005453-4057qib7 8870 19 and and CC cord-005453-4057qib7 8870 20 Leukemia Leukemia NNP cord-005453-4057qib7 8870 21 patients patient NNS cord-005453-4057qib7 8870 22 . . . cord-005453-4057qib7 8871 1 Disclosure disclosure NN cord-005453-4057qib7 8871 2 : : : cord-005453-4057qib7 8871 3 Nothing nothing NN cord-005453-4057qib7 8871 4 to to TO cord-005453-4057qib7 8871 5 declare declare VB cord-005453-4057qib7 8871 6 Background background NN cord-005453-4057qib7 8871 7 : : : cord-005453-4057qib7 8872 1 The the DT cord-005453-4057qib7 8872 2 incidence incidence NN cord-005453-4057qib7 8872 3 of of IN cord-005453-4057qib7 8872 4 hepatitis hepatitis NN cord-005453-4057qib7 8872 5 B B NNP cord-005453-4057qib7 8872 6 virus virus NN cord-005453-4057qib7 8872 7 infection infection NN cord-005453-4057qib7 8872 8 is be VBZ cord-005453-4057qib7 8872 9 high high JJ cord-005453-4057qib7 8872 10 to to IN cord-005453-4057qib7 8872 11 6.2 6.2 CD cord-005453-4057qib7 8872 12 % % NN cord-005453-4057qib7 8872 13 in in IN cord-005453-4057qib7 8872 14 Asian asian JJ cord-005453-4057qib7 8872 15 population population NN cord-005453-4057qib7 8872 16 , , , cord-005453-4057qib7 8873 1 So so CC cord-005453-4057qib7 8873 2 there there EX cord-005453-4057qib7 8873 3 is be VBZ cord-005453-4057qib7 8873 4 more more JJR cord-005453-4057qib7 8873 5 and and CC cord-005453-4057qib7 8873 6 more more JJR cord-005453-4057qib7 8873 7 attention attention NN cord-005453-4057qib7 8873 8 to to IN cord-005453-4057qib7 8873 9 the the DT cord-005453-4057qib7 8873 10 risk risk NN cord-005453-4057qib7 8873 11 of of IN cord-005453-4057qib7 8873 12 hepatitis hepatitis NN cord-005453-4057qib7 8873 13 B B NNP cord-005453-4057qib7 8873 14 virus(HBV virus(HBV NNP cord-005453-4057qib7 8873 15 ) ) -RRB- cord-005453-4057qib7 8873 16 reactivation reactivation NN cord-005453-4057qib7 8873 17 in in IN cord-005453-4057qib7 8873 18 the the DT cord-005453-4057qib7 8873 19 hepatitis hepatitis NN cord-005453-4057qib7 8873 20 B B NNP cord-005453-4057qib7 8873 21 core core NN cord-005453-4057qib7 8873 22 antibody antibody NN cord-005453-4057qib7 8873 23 positive positive JJ cord-005453-4057qib7 8873 24 patients patient NNS cord-005453-4057qib7 8873 25 during during IN cord-005453-4057qib7 8873 26 chemotherapy chemotherapy NN cord-005453-4057qib7 8873 27 , , , cord-005453-4057qib7 8873 28 anti anti JJ cord-005453-4057qib7 8873 29 - - JJ cord-005453-4057qib7 8873 30 CD20 cd20 JJ cord-005453-4057qib7 8873 31 monoclonal monoclonal JJ cord-005453-4057qib7 8873 32 antibody antibody NN cord-005453-4057qib7 8873 33 , , , cord-005453-4057qib7 8873 34 HSCT HSCT NNP cord-005453-4057qib7 8873 35 , , , cord-005453-4057qib7 8873 36 or or CC cord-005453-4057qib7 8873 37 other other JJ cord-005453-4057qib7 8873 38 intense intense JJ cord-005453-4057qib7 8873 39 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 8873 40 drug drug NN cord-005453-4057qib7 8873 41 therapy therapy NN cord-005453-4057qib7 8873 42 ( ( -LRB- cord-005453-4057qib7 8873 43 ISDT ISDT NNP cord-005453-4057qib7 8873 44 ) ) -RRB- cord-005453-4057qib7 8873 45 . . . cord-005453-4057qib7 8874 1 Hepatitis Hepatitis NNP cord-005453-4057qib7 8874 2 B B NNP cord-005453-4057qib7 8874 3 Core Core NNP cord-005453-4057qib7 8874 4 Antibody Antibody NNP cord-005453-4057qib7 8874 5 is be VBZ cord-005453-4057qib7 8874 6 associated associate VBN cord-005453-4057qib7 8874 7 with with IN cord-005453-4057qib7 8874 8 a a DT cord-005453-4057qib7 8874 9 significant significant JJ cord-005453-4057qib7 8874 10 risk risk NN cord-005453-4057qib7 8874 11 of of IN cord-005453-4057qib7 8874 12 HBV HBV NNP cord-005453-4057qib7 8874 13 reactivation reactivation NN cord-005453-4057qib7 8874 14 in in IN cord-005453-4057qib7 8874 15 patients patient NNS cord-005453-4057qib7 8874 16 undergoing undergo VBG cord-005453-4057qib7 8874 17 HSCT HSCT NNP cord-005453-4057qib7 8874 18 . . . cord-005453-4057qib7 8875 1 However however RB cord-005453-4057qib7 8875 2 , , , cord-005453-4057qib7 8875 3 There there EX cord-005453-4057qib7 8875 4 are be VBP cord-005453-4057qib7 8875 5 remain remain RB cord-005453-4057qib7 8875 6 uncertain uncertain JJ cord-005453-4057qib7 8875 7 that that IN cord-005453-4057qib7 8875 8 the the DT cord-005453-4057qib7 8875 9 effect effect NN cord-005453-4057qib7 8875 10 of of IN cord-005453-4057qib7 8875 11 anti anti JJ cord-005453-4057qib7 8875 12 - - JJ cord-005453-4057qib7 8875 13 HbsAg hbsag JJ cord-005453-4057qib7 8875 14 antibodies antibody NNS cord-005453-4057qib7 8875 15 in in IN cord-005453-4057qib7 8875 16 hepatitis hepatitis NNP cord-005453-4057qib7 8875 17 B B NNP cord-005453-4057qib7 8875 18 virus virus NN cord-005453-4057qib7 8875 19 reactivation reactivation NN cord-005453-4057qib7 8875 20 among among IN cord-005453-4057qib7 8875 21 the the DT cord-005453-4057qib7 8875 22 hepatitis hepatitis NN cord-005453-4057qib7 8875 23 B B NNP cord-005453-4057qib7 8875 24 core core NN cord-005453-4057qib7 8875 25 antibody antibody NN cord-005453-4057qib7 8875 26 positive positive JJ cord-005453-4057qib7 8875 27 patients patient NNS cord-005453-4057qib7 8875 28 undergo undergo VBP cord-005453-4057qib7 8875 29 HSCT HSCT NNP cord-005453-4057qib7 8875 30 . . . cord-005453-4057qib7 8876 1 We -PRON- PRP cord-005453-4057qib7 8876 2 aim aim VBP cord-005453-4057qib7 8876 3 to to TO cord-005453-4057qib7 8876 4 investigate investigate VB cord-005453-4057qib7 8876 5 the the DT cord-005453-4057qib7 8876 6 role role NN cord-005453-4057qib7 8876 7 of of IN cord-005453-4057qib7 8876 8 the the DT cord-005453-4057qib7 8876 9 anti anti JJ cord-005453-4057qib7 8876 10 - - JJ cord-005453-4057qib7 8876 11 HBs hb NNS cord-005453-4057qib7 8876 12 and and CC cord-005453-4057qib7 8876 13 the the DT cord-005453-4057qib7 8876 14 necessity necessity NN cord-005453-4057qib7 8876 15 of of IN cord-005453-4057qib7 8876 16 anti anti JJ cord-005453-4057qib7 8876 17 virus virus NN cord-005453-4057qib7 8876 18 in in IN cord-005453-4057qib7 8876 19 hepatitis hepatitis NNP cord-005453-4057qib7 8876 20 B B NNP cord-005453-4057qib7 8876 21 surface surface NN cord-005453-4057qib7 8876 22 antigen(HBsAg antigen(hbsag ADD cord-005453-4057qib7 8876 23 ) ) -RRB- cord-005453-4057qib7 8876 24 negative negative JJ cord-005453-4057qib7 8876 25 , , , cord-005453-4057qib7 8876 26 hepatitis hepatitis NNP cord-005453-4057qib7 8876 27 B B NNP cord-005453-4057qib7 8876 28 core core NN cord-005453-4057qib7 8876 29 antibody antibody NN cord-005453-4057qib7 8876 30 positive positive JJ cord-005453-4057qib7 8876 31 patients patient NNS cord-005453-4057qib7 8876 32 during during IN cord-005453-4057qib7 8876 33 HSCT HSCT NNP cord-005453-4057qib7 8876 34 . . . cord-005453-4057qib7 8877 1 Methods method NNS cord-005453-4057qib7 8877 2 : : : cord-005453-4057qib7 8877 3 we -PRON- PRP cord-005453-4057qib7 8877 4 enrolled enrol VBD cord-005453-4057qib7 8878 1 791 791 CD cord-005453-4057qib7 8878 2 hematological hematological JJ cord-005453-4057qib7 8878 3 malignant malignant JJ cord-005453-4057qib7 8878 4 patients patient NNS cord-005453-4057qib7 8878 5 received receive VBD cord-005453-4057qib7 8878 6 HSCT HSCT NNP cord-005453-4057qib7 8878 7 in in IN cord-005453-4057qib7 8878 8 our -PRON- PRP$ cord-005453-4057qib7 8878 9 center center NN cord-005453-4057qib7 8878 10 from from IN cord-005453-4057qib7 8878 11 2008 2008 CD cord-005453-4057qib7 8878 12 to to IN cord-005453-4057qib7 8878 13 2016 2016 CD cord-005453-4057qib7 8878 14 . . . cord-005453-4057qib7 8879 1 we -PRON- PRP cord-005453-4057qib7 8879 2 classified classify VBD cord-005453-4057qib7 8879 3 665 665 CD cord-005453-4057qib7 8879 4 HBsAg hbsag CD cord-005453-4057qib7 8879 5 negative negative JJ cord-005453-4057qib7 8879 6 and and CC cord-005453-4057qib7 8879 7 undetectable undetectable JJ cord-005453-4057qib7 8879 8 HBV HBV NNP cord-005453-4057qib7 8879 9 DNA DNA NNP cord-005453-4057qib7 8879 10 patients patient NNS cord-005453-4057qib7 8879 11 into into IN cord-005453-4057qib7 8879 12 4 4 CD cord-005453-4057qib7 8879 13 groups group NNS cord-005453-4057qib7 8879 14 as as IN cord-005453-4057qib7 8879 15 anti anti NNP cord-005453-4057qib7 8879 16 - - JJ cord-005453-4057qib7 8879 17 HBc(-)anti hbc(-)anti NN cord-005453-4057qib7 8879 18 - - HYPH cord-005453-4057qib7 8879 19 HBs(- hbs(- NN cord-005453-4057qib7 8879 20 ) ) -RRB- cord-005453-4057qib7 8880 1 ( ( -LRB- cord-005453-4057qib7 8880 2 n=189 n=189 CD cord-005453-4057qib7 8880 3 ) ) -RRB- cord-005453-4057qib7 8880 4 , , , cord-005453-4057qib7 8880 5 anti anti JJ cord-005453-4057qib7 8880 6 - - JJ cord-005453-4057qib7 8880 7 HBc(-)anti hbc(-)anti JJ cord-005453-4057qib7 8880 8 - - HYPH cord-005453-4057qib7 8880 9 HBs(+ HBs(+ NNP cord-005453-4057qib7 8880 10 ) ) -RRB- cord-005453-4057qib7 8881 1 ( ( -LRB- cord-005453-4057qib7 8881 2 n=176 n=176 NNP cord-005453-4057qib7 8881 3 ) ) -RRB- cord-005453-4057qib7 8881 4 , , , cord-005453-4057qib7 8881 5 anti anti JJ cord-005453-4057qib7 8881 6 - - JJ cord-005453-4057qib7 8881 7 HBc(+ hbc(+ JJ cord-005453-4057qib7 8881 8 ) ) -RRB- cord-005453-4057qib7 8881 9 anti anti NNS cord-005453-4057qib7 8881 10 - - NN cord-005453-4057qib7 8881 11 HBs(- hbs(- JJ cord-005453-4057qib7 8881 12 ) ) -RRB- cord-005453-4057qib7 8881 13 ( ( -LRB- cord-005453-4057qib7 8881 14 n=49 n=49 NNP cord-005453-4057qib7 8881 15 ) ) -RRB- cord-005453-4057qib7 8881 16 , , , cord-005453-4057qib7 8881 17 and and CC cord-005453-4057qib7 8881 18 anti anti JJ cord-005453-4057qib7 8881 19 - - JJ cord-005453-4057qib7 8881 20 HBc(+)anti hbc(+)anti JJ cord-005453-4057qib7 8881 21 - - HYPH cord-005453-4057qib7 8881 22 HBs(+ hbs(+ NN cord-005453-4057qib7 8881 23 ) ) -RRB- cord-005453-4057qib7 8882 1 ( ( -LRB- cord-005453-4057qib7 8882 2 n=251 n=251 NNP cord-005453-4057qib7 8882 3 ) ) -RRB- cord-005453-4057qib7 8882 4 . . . cord-005453-4057qib7 8883 1 Results result NNS cord-005453-4057qib7 8883 2 : : : cord-005453-4057qib7 8884 1 HBV HBV NNP cord-005453-4057qib7 8884 2 reactivation reactivation NN cord-005453-4057qib7 8884 3 was be VBD cord-005453-4057qib7 8884 4 identified identify VBN cord-005453-4057qib7 8884 5 in in IN cord-005453-4057qib7 8884 6 16 16 CD cord-005453-4057qib7 8884 7 patients patient NNS cord-005453-4057qib7 8884 8 ( ( -LRB- cord-005453-4057qib7 8884 9 2.4 2.4 CD cord-005453-4057qib7 8884 10 % % NN cord-005453-4057qib7 8884 11 ) ) -RRB- cord-005453-4057qib7 8884 12 after after IN cord-005453-4057qib7 8884 13 HSCT HSCT NNP cord-005453-4057qib7 8884 14 . . . cord-005453-4057qib7 8885 1 There there EX cord-005453-4057qib7 8885 2 was be VBD cord-005453-4057qib7 8885 3 a a DT cord-005453-4057qib7 8885 4 significant significant JJ cord-005453-4057qib7 8885 5 difference difference NN cord-005453-4057qib7 8885 6 in in IN cord-005453-4057qib7 8885 7 HBV HBV NNP cord-005453-4057qib7 8885 8 reactivation reactivation NN cord-005453-4057qib7 8885 9 rate rate NN cord-005453-4057qib7 8885 10 in in IN cord-005453-4057qib7 8885 11 anti anti JJ cord-005453-4057qib7 8885 12 - - JJ cord-005453-4057qib7 8885 13 HBc(+)anti hbc(+)anti NN cord-005453-4057qib7 8885 14 - - HYPH cord-005453-4057qib7 8885 15 HBs(- hbs(- NN cord-005453-4057qib7 8885 16 ) ) -RRB- cord-005453-4057qib7 8885 17 ( ( -LRB- cord-005453-4057qib7 8885 18 12.2 12.2 CD cord-005453-4057qib7 8885 19 % % NN cord-005453-4057qib7 8885 20 ) ) -RRB- cord-005453-4057qib7 8885 21 vs vs IN cord-005453-4057qib7 8885 22 anti anti JJ cord-005453-4057qib7 8885 23 - - JJ cord-005453-4057qib7 8885 24 HBc(+)anti hbc(+)anti JJ cord-005453-4057qib7 8885 25 - - HYPH cord-005453-4057qib7 8885 26 HBs(+ hbs(+ NN cord-005453-4057qib7 8885 27 ) ) -RRB- cord-005453-4057qib7 8885 28 ( ( -LRB- cord-005453-4057qib7 8885 29 2.8 2.8 CD cord-005453-4057qib7 8885 30 % % NN cord-005453-4057qib7 8885 31 ) ) -RRB- cord-005453-4057qib7 8885 32 ( ( -LRB- cord-005453-4057qib7 8885 33 p=0.01 p=0.01 NNP cord-005453-4057qib7 8885 34 ) ) -RRB- cord-005453-4057qib7 8885 35 and and CC cord-005453-4057qib7 8885 36 anti anti JJ cord-005453-4057qib7 8885 37 - - JJ cord-005453-4057qib7 8885 38 HBc hbc JJ cord-005453-4057qib7 8885 39 ( ( -LRB- cord-005453-4057qib7 8885 40 + + SYM cord-005453-4057qib7 8885 41 ) ) -RRB- cord-005453-4057qib7 8885 42 anti anti NNS cord-005453-4057qib7 8885 43 - - NN cord-005453-4057qib7 8885 44 HBs(- hbs(- JJ cord-005453-4057qib7 8885 45 ) ) -RRB- cord-005453-4057qib7 8885 46 ( ( -LRB- cord-005453-4057qib7 8885 47 12.2 12.2 CD cord-005453-4057qib7 8885 48 % % NN cord-005453-4057qib7 8885 49 ) ) -RRB- cord-005453-4057qib7 8885 50 vs vs IN cord-005453-4057qib7 8885 51 anti anti NNP cord-005453-4057qib7 8885 52 - - JJ cord-005453-4057qib7 8885 53 HBc(-)anti hbc(-)anti NN cord-005453-4057qib7 8885 54 - - HYPH cord-005453-4057qib7 8885 55 HBs(- hbs(- LS cord-005453-4057qib7 8885 56 ) ) -RRB- cord-005453-4057qib7 8885 57 ( ( -LRB- cord-005453-4057qib7 8885 58 0.0 0.0 CD cord-005453-4057qib7 8885 59 % % NN cord-005453-4057qib7 8885 60 ) ) -RRB- cord-005453-4057qib7 8885 61 ( ( -LRB- cord-005453-4057qib7 8885 62 p=0.000 p=0.000 NNP cord-005453-4057qib7 8885 63 ) ) -RRB- cord-005453-4057qib7 8885 64 , , , cord-005453-4057qib7 8885 65 anti anti JJ cord-005453-4057qib7 8885 66 - - JJ cord-005453-4057qib7 8885 67 HBc(+)anti hbc(+)anti NN cord-005453-4057qib7 8885 68 - - HYPH cord-005453-4057qib7 8885 69 HBs(- hbs(- NN cord-005453-4057qib7 8885 70 ) ) -RRB- cord-005453-4057qib7 8885 71 ( ( -LRB- cord-005453-4057qib7 8885 72 12.2 12.2 CD cord-005453-4057qib7 8885 73 % % NN cord-005453-4057qib7 8885 74 ) ) -RRB- cord-005453-4057qib7 8885 75 vs vs IN cord-005453-4057qib7 8885 76 anti anti NNP cord-005453-4057qib7 8885 77 - - NNS cord-005453-4057qib7 8885 78 HBc(- hbc(- JJ cord-005453-4057qib7 8885 79 ) ) -RRB- cord-005453-4057qib7 8885 80 anti anti JJ cord-005453-4057qib7 8885 81 - - JJ cord-005453-4057qib7 8885 82 HBs(+ hbs(+ JJ cord-005453-4057qib7 8885 83 ) ) -RRB- cord-005453-4057qib7 8886 1 ( ( -LRB- cord-005453-4057qib7 8886 2 1.7 1.7 CD cord-005453-4057qib7 8886 3 % % NN cord-005453-4057qib7 8886 4 ) ) -RRB- cord-005453-4057qib7 8886 5 ( ( -LRB- cord-005453-4057qib7 8886 6 p=0.004 p=0.004 NNP cord-005453-4057qib7 8886 7 ) ) -RRB- cord-005453-4057qib7 8886 8 , , , cord-005453-4057qib7 8886 9 but but CC cord-005453-4057qib7 8886 10 not not RB cord-005453-4057qib7 8886 11 among among IN cord-005453-4057qib7 8886 12 anti anti JJ cord-005453-4057qib7 8886 13 - - JJ cord-005453-4057qib7 8886 14 HBc(+ hbc(+ JJ cord-005453-4057qib7 8886 15 ) ) -RRB- cord-005453-4057qib7 8886 16 anti anti JJ cord-005453-4057qib7 8886 17 - - JJ cord-005453-4057qib7 8886 18 HBs(+ hbs(+ JJ cord-005453-4057qib7 8886 19 ) ) -RRB- cord-005453-4057qib7 8886 20 ( ( -LRB- cord-005453-4057qib7 8886 21 2.8 2.8 CD cord-005453-4057qib7 8886 22 % % NN cord-005453-4057qib7 8886 23 ) ) -RRB- cord-005453-4057qib7 8886 24 and and CC cord-005453-4057qib7 8886 25 anti anti JJ cord-005453-4057qib7 8886 26 - - JJ cord-005453-4057qib7 8886 27 HBc(-)anti hbc(-)anti NN cord-005453-4057qib7 8886 28 - - HYPH cord-005453-4057qib7 8886 29 HBs(- hbs(- LS cord-005453-4057qib7 8886 30 ) ) -RRB- cord-005453-4057qib7 8886 31 ( ( -LRB- cord-005453-4057qib7 8886 32 0 0 CD cord-005453-4057qib7 8886 33 % % NN cord-005453-4057qib7 8886 34 ) ) -RRB- cord-005453-4057qib7 8886 35 and and CC cord-005453-4057qib7 8886 36 anti anti JJ cord-005453-4057qib7 8886 37 - - JJ cord-005453-4057qib7 8886 38 HBc(-)anti hbc(-)anti JJ cord-005453-4057qib7 8886 39 - - HYPH cord-005453-4057qib7 8886 40 HBs(+ HBs(+ NNP cord-005453-4057qib7 8886 41 ) ) -RRB- cord-005453-4057qib7 8886 42 ( ( -LRB- cord-005453-4057qib7 8886 43 1.7 1.7 CD cord-005453-4057qib7 8886 44 % % NN cord-005453-4057qib7 8886 45 ) ) -RRB- cord-005453-4057qib7 8886 46 . . . cord-005453-4057qib7 8887 1 Whereas whereas IN cord-005453-4057qib7 8887 2 there there EX cord-005453-4057qib7 8887 3 were be VBD cord-005453-4057qib7 8887 4 no no DT cord-005453-4057qib7 8887 5 difference difference NN cord-005453-4057qib7 8887 6 according accord VBG cord-005453-4057qib7 8887 7 to to IN cord-005453-4057qib7 8887 8 the the DT cord-005453-4057qib7 8887 9 donor donor NN cord-005453-4057qib7 8887 10 viral viral NN cord-005453-4057qib7 8887 11 profile(p=0.774 profile(p=0.774 FW cord-005453-4057qib7 8887 12 ) ) -RRB- cord-005453-4057qib7 8887 13 . . . cord-005453-4057qib7 8888 1 The the DT cord-005453-4057qib7 8888 2 median median JJ cord-005453-4057qib7 8888 3 time time NN cord-005453-4057qib7 8888 4 of of IN cord-005453-4057qib7 8888 5 HBV HBV NNP cord-005453-4057qib7 8888 6 reactivation reactivation NN cord-005453-4057qib7 8888 7 in in IN cord-005453-4057qib7 8888 8 HBsAg hbsag ADD cord-005453-4057qib7 8889 1 negative negative JJ cord-005453-4057qib7 8889 2 patients patient NNS cord-005453-4057qib7 8889 3 accepted accept VBD cord-005453-4057qib7 8889 4 HSCT HSCT NNP cord-005453-4057qib7 8889 5 was be VBD cord-005453-4057qib7 8890 1 645 645 CD cord-005453-4057qib7 8890 2 ( ( -LRB- cord-005453-4057qib7 8890 3 455 455 CD cord-005453-4057qib7 8890 4 - - SYM cord-005453-4057qib7 8890 5 1957 1957 CD cord-005453-4057qib7 8890 6 ) ) -RRB- cord-005453-4057qib7 8890 7 days day NNS cord-005453-4057qib7 8890 8 after after IN cord-005453-4057qib7 8890 9 HSCT HSCT NNP cord-005453-4057qib7 8890 10 . . . cord-005453-4057qib7 8891 1 All all DT cord-005453-4057qib7 8891 2 of of IN cord-005453-4057qib7 8891 3 the the DT cord-005453-4057qib7 8891 4 patients patient NNS cord-005453-4057qib7 8891 5 with with IN cord-005453-4057qib7 8891 6 HBV HBV NNP cord-005453-4057qib7 8891 7 reactivation reactivation NN cord-005453-4057qib7 8891 8 have have VBP cord-005453-4057qib7 8891 9 been be VBN cord-005453-4057qib7 8891 10 controlled control VBN cord-005453-4057qib7 8891 11 with with IN cord-005453-4057qib7 8891 12 Nucleos(t)ide nucleos(t)ide JJ cord-005453-4057qib7 8891 13 Analogues Analogues NNP cord-005453-4057qib7 8891 14 drugs drug NNS cord-005453-4057qib7 8891 15 , , , cord-005453-4057qib7 8891 16 and and CC cord-005453-4057qib7 8891 17 5 5 CD cord-005453-4057qib7 8891 18 of of IN cord-005453-4057qib7 8891 19 them -PRON- PRP cord-005453-4057qib7 8891 20 achieved achieve VBD cord-005453-4057qib7 8891 21 reverse reverse JJ cord-005453-4057qib7 8891 22 seroconversion seroconversion NN cord-005453-4057qib7 8891 23 which which WDT cord-005453-4057qib7 8891 24 detect detect VBP cord-005453-4057qib7 8891 25 persistent persistent JJ cord-005453-4057qib7 8891 26 anti anti JJ cord-005453-4057qib7 8891 27 - - JJ cord-005453-4057qib7 8891 28 HbsAg hbsag JJ cord-005453-4057qib7 8891 29 antibodies antibody NNS cord-005453-4057qib7 8891 30 in in IN cord-005453-4057qib7 8891 31 their -PRON- PRP$ cord-005453-4057qib7 8891 32 bodies body NNS cord-005453-4057qib7 8891 33 . . . cord-005453-4057qib7 8892 1 Conclusions conclusion NNS cord-005453-4057qib7 8892 2 : : : cord-005453-4057qib7 8893 1 The the DT cord-005453-4057qib7 8893 2 anti anti JJ cord-005453-4057qib7 8893 3 - - JJ cord-005453-4057qib7 8893 4 HbsAg hbsag JJ cord-005453-4057qib7 8893 5 antibodies antibody NNS cord-005453-4057qib7 8893 6 negative negative JJ cord-005453-4057qib7 8893 7 and and CC cord-005453-4057qib7 8893 8 anti anti JJ cord-005453-4057qib7 8893 9 - - JJ cord-005453-4057qib7 8893 10 HBc hbc JJ cord-005453-4057qib7 8893 11 positive positive JJ cord-005453-4057qib7 8893 12 patients patient NNS cord-005453-4057qib7 8893 13 have have VBP cord-005453-4057qib7 8893 14 the the DT cord-005453-4057qib7 8893 15 highest high JJS cord-005453-4057qib7 8893 16 risk risk NN cord-005453-4057qib7 8893 17 of of IN cord-005453-4057qib7 8893 18 HBV HBV NNP cord-005453-4057qib7 8893 19 reactivation reactivation NN cord-005453-4057qib7 8893 20 after after IN cord-005453-4057qib7 8893 21 HSCT HSCT NNP cord-005453-4057qib7 8893 22 in in IN cord-005453-4057qib7 8893 23 resolved resolve VBD cord-005453-4057qib7 8893 24 HBV HBV NNP cord-005453-4057qib7 8893 25 patients patient NNS cord-005453-4057qib7 8893 26 . . . cord-005453-4057qib7 8894 1 The the DT cord-005453-4057qib7 8894 2 anti anti JJ cord-005453-4057qib7 8894 3 - - JJ cord-005453-4057qib7 8894 4 HbsAg hbsag JJ cord-005453-4057qib7 8894 5 antibodies antibody NNS cord-005453-4057qib7 8894 6 play play VBP cord-005453-4057qib7 8894 7 a a DT cord-005453-4057qib7 8894 8 protective protective JJ cord-005453-4057qib7 8894 9 role role NN cord-005453-4057qib7 8894 10 in in IN cord-005453-4057qib7 8894 11 resolved resolve VBD cord-005453-4057qib7 8894 12 HBV HBV NNP cord-005453-4057qib7 8894 13 patients patient NNS cord-005453-4057qib7 8894 14 receiving receive VBG cord-005453-4057qib7 8894 15 HSCT HSCT NNP cord-005453-4057qib7 8894 16 . . . cord-005453-4057qib7 8895 1 We -PRON- PRP cord-005453-4057qib7 8895 2 recommend recommend VBP cord-005453-4057qib7 8895 3 not not RB cord-005453-4057qib7 8895 4 prophylactic prophylactic JJ cord-005453-4057qib7 8895 5 anti anti JJ cord-005453-4057qib7 8895 6 hepatitis hepatitis NNP cord-005453-4057qib7 8895 7 B B NNP cord-005453-4057qib7 8895 8 virus virus NN cord-005453-4057qib7 8895 9 in in IN cord-005453-4057qib7 8895 10 HBsAg hbsag ADD cord-005453-4057qib7 8895 11 negativity negativity NN cord-005453-4057qib7 8895 12 and and CC cord-005453-4057qib7 8895 13 anti anti JJ cord-005453-4057qib7 8895 14 - - JJ cord-005453-4057qib7 8895 15 HbsAg HbsAg NNP cord-005453-4057qib7 8895 16 antibodies antibody NNS cord-005453-4057qib7 8895 17 positive positive JJ cord-005453-4057qib7 8895 18 patients patient NNS cord-005453-4057qib7 8895 19 following follow VBG cord-005453-4057qib7 8895 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 8895 21 stem stem NN cord-005453-4057qib7 8895 22 cell cell NN cord-005453-4057qib7 8895 23 transplantation transplantation NN cord-005453-4057qib7 8895 24 . . . cord-005453-4057qib7 8896 1 Disclosure disclosure NN cord-005453-4057qib7 8896 2 : : : cord-005453-4057qib7 8896 3 Nothing nothing NN cord-005453-4057qib7 8896 4 to to TO cord-005453-4057qib7 8896 5 declare declare VB cord-005453-4057qib7 8896 6 Methods method NNS cord-005453-4057qib7 8896 7 : : : cord-005453-4057qib7 8896 8 2230 2230 CD cord-005453-4057qib7 8896 9 allo allo NN cord-005453-4057qib7 8896 10 - - HYPH cord-005453-4057qib7 8896 11 HSCTs hsct NNS cord-005453-4057qib7 8896 12 performed perform VBN cord-005453-4057qib7 8896 13 between between IN cord-005453-4057qib7 8896 14 1997 1997 CD cord-005453-4057qib7 8896 15 and and CC cord-005453-4057qib7 8896 16 2016 2016 CD cord-005453-4057qib7 8896 17 for for IN cord-005453-4057qib7 8896 18 acquired acquire VBN cord-005453-4057qib7 8896 19 bone bone NN cord-005453-4057qib7 8896 20 marrow marrow NN cord-005453-4057qib7 8896 21 failure failure NN cord-005453-4057qib7 8896 22 ( ( -LRB- cord-005453-4057qib7 8896 23 70.6 70.6 CD cord-005453-4057qib7 8896 24 % % NN cord-005453-4057qib7 8896 25 ) ) -RRB- cord-005453-4057qib7 8896 26 or or CC cord-005453-4057qib7 8896 27 hemoglobinopathies hemoglobinopathy NNS cord-005453-4057qib7 8896 28 ( ( -LRB- cord-005453-4057qib7 8896 29 29.4 29.4 CD cord-005453-4057qib7 8896 30 % % NN cord-005453-4057qib7 8896 31 ) ) -RRB- cord-005453-4057qib7 8896 32 , , , cord-005453-4057qib7 8896 33 with with IN cord-005453-4057qib7 8896 34 BM±CB BM±CB NNP cord-005453-4057qib7 8896 35 ( ( -LRB- cord-005453-4057qib7 8896 36 75.8 75.8 CD cord-005453-4057qib7 8896 37 % % NN cord-005453-4057qib7 8896 38 ) ) -RRB- cord-005453-4057qib7 8896 39 or or CC cord-005453-4057qib7 8896 40 PB±CB+BM PB±CB+BM NNP cord-005453-4057qib7 8896 41 ( ( -LRB- cord-005453-4057qib7 8896 42 24.2 24.2 CD cord-005453-4057qib7 8896 43 % % NN cord-005453-4057qib7 8896 44 ) ) -RRB- cord-005453-4057qib7 8896 45 as as IN cord-005453-4057qib7 8896 46 a a DT cord-005453-4057qib7 8896 47 stem stem NN cord-005453-4057qib7 8896 48 cell cell NN cord-005453-4057qib7 8896 49 source source NN cord-005453-4057qib7 8896 50 were be VBD cord-005453-4057qib7 8896 51 included include VBN cord-005453-4057qib7 8896 52 in in IN cord-005453-4057qib7 8896 53 this this DT cord-005453-4057qib7 8896 54 retrospective retrospective JJ cord-005453-4057qib7 8896 55 Registry registry NN cord-005453-4057qib7 8896 56 megafile megafile NN cord-005453-4057qib7 8896 57 IDWP IDWP NNP cord-005453-4057qib7 8896 58 EBMT EBMT NNP cord-005453-4057qib7 8896 59 study study NN cord-005453-4057qib7 8896 60 . . . cord-005453-4057qib7 8897 1 Results result NNS cord-005453-4057qib7 8897 2 : : : cord-005453-4057qib7 8897 3 DEMOGRAPHICS demographic NNS cord-005453-4057qib7 8897 4 : : : cord-005453-4057qib7 8898 1 The the DT cord-005453-4057qib7 8898 2 median median JJ cord-005453-4057qib7 8898 3 age age NN cord-005453-4057qib7 8898 4 of of IN cord-005453-4057qib7 8898 5 recipient recipient NN cord-005453-4057qib7 8898 6 was be VBD cord-005453-4057qib7 8898 7 17.7 17.7 CD cord-005453-4057qib7 8898 8 years year NNS cord-005453-4057qib7 8899 1 ( ( -LRB- cord-005453-4057qib7 8899 2 range range NN cord-005453-4057qib7 8899 3 : : : cord-005453-4057qib7 8899 4 0.1 0.1 CD cord-005453-4057qib7 8899 5 - - SYM cord-005453-4057qib7 8899 6 78 78 CD cord-005453-4057qib7 8899 7 ) ) -RRB- cord-005453-4057qib7 8899 8 , , , cord-005453-4057qib7 8899 9 and and CC cord-005453-4057qib7 8899 10 50.8 50.8 CD cord-005453-4057qib7 8899 11 % % NN cord-005453-4057qib7 8899 12 were be VBD cord-005453-4057qib7 8899 13 children child NNS cord-005453-4057qib7 8899 14 . . . cord-005453-4057qib7 8900 1 79.0 79.0 CD cord-005453-4057qib7 8900 2 % % NN cord-005453-4057qib7 8900 3 recipients recipient NNS cord-005453-4057qib7 8900 4 and and CC cord-005453-4057qib7 8900 5 75.4 75.4 CD cord-005453-4057qib7 8900 6 % % NN cord-005453-4057qib7 8900 7 donors donor NNS cord-005453-4057qib7 8900 8 were be VBD cord-005453-4057qib7 8900 9 EBV EBV NNP cord-005453-4057qib7 8900 10 - - HYPH cord-005453-4057qib7 8900 11 seropositive seropositive JJ cord-005453-4057qib7 8900 12 . . . cord-005453-4057qib7 8901 1 67.8 67.8 CD cord-005453-4057qib7 8901 2 % % NN cord-005453-4057qib7 8901 3 had have VBD cord-005453-4057qib7 8901 4 HSCT HSCT NNP cord-005453-4057qib7 8901 5 from from IN cord-005453-4057qib7 8901 6 a a DT cord-005453-4057qib7 8901 7 matched match VBN cord-005453-4057qib7 8901 8 family family NN cord-005453-4057qib7 8901 9 donor donor NN cord-005453-4057qib7 8901 10 , , , cord-005453-4057qib7 8901 11 4.6 4.6 CD cord-005453-4057qib7 8901 12 % % NN cord-005453-4057qib7 8901 13 from from IN cord-005453-4057qib7 8901 14 a a DT cord-005453-4057qib7 8901 15 mismatched mismatched JJ cord-005453-4057qib7 8901 16 family family NN cord-005453-4057qib7 8901 17 donor donor NN cord-005453-4057qib7 8901 18 , , , cord-005453-4057qib7 8901 19 and and CC cord-005453-4057qib7 8901 20 27.6 27.6 CD cord-005453-4057qib7 8901 21 % % NN cord-005453-4057qib7 8901 22 from from IN cord-005453-4057qib7 8901 23 an an DT cord-005453-4057qib7 8901 24 unrelated unrelated JJ cord-005453-4057qib7 8901 25 donor donor NN cord-005453-4057qib7 8901 26 . . . cord-005453-4057qib7 8902 1 T t NN cord-005453-4057qib7 8902 2 - - HYPH cord-005453-4057qib7 8902 3 cell cell NN cord-005453-4057qib7 8902 4 depletion depletion NN cord-005453-4057qib7 8902 5 was be VBD cord-005453-4057qib7 8902 6 performed perform VBN cord-005453-4057qib7 8902 7 in in IN cord-005453-4057qib7 8902 8 vivo vivo NN cord-005453-4057qib7 8902 9 in in IN cord-005453-4057qib7 8902 10 82.2 82.2 CD cord-005453-4057qib7 8902 11 % % NN cord-005453-4057qib7 8902 12 , , , cord-005453-4057qib7 8902 13 and and CC cord-005453-4057qib7 8902 14 ex ex FW cord-005453-4057qib7 8902 15 vivo vivo NN cord-005453-4057qib7 8902 16 in in IN cord-005453-4057qib7 8902 17 6.6 6.6 CD cord-005453-4057qib7 8902 18 % % NN cord-005453-4057qib7 8902 19 patients patient NNS cord-005453-4057qib7 8902 20 . . . cord-005453-4057qib7 8903 1 Conditioning conditioning NN cord-005453-4057qib7 8903 2 regimen regimen NN cord-005453-4057qib7 8903 3 was be VBD cord-005453-4057qib7 8903 4 myeloablative myeloablative JJ cord-005453-4057qib7 8903 5 in in IN cord-005453-4057qib7 8903 6 63.7 63.7 CD cord-005453-4057qib7 8903 7 % % NN cord-005453-4057qib7 8903 8 , , , cord-005453-4057qib7 8903 9 RIC RIC NNP cord-005453-4057qib7 8903 10 in in IN cord-005453-4057qib7 8903 11 36.3 36.3 CD cord-005453-4057qib7 8903 12 % % NN cord-005453-4057qib7 8903 13 . . . cord-005453-4057qib7 8904 1 Median median JJ cord-005453-4057qib7 8904 2 follow follow NN cord-005453-4057qib7 8904 3 - - HYPH cord-005453-4057qib7 8904 4 up up NN cord-005453-4057qib7 8904 5 was be VBD cord-005453-4057qib7 8904 6 4.7 4.7 CD cord-005453-4057qib7 8904 7 years year NNS cord-005453-4057qib7 8904 8 ( ( -LRB- cord-005453-4057qib7 8904 9 95 95 CD cord-005453-4057qib7 8904 10 % % NN cord-005453-4057qib7 8904 11 C.I. C.I. NNP cord-005453-4057qib7 8904 12 4.3 4.3 CD cord-005453-4057qib7 8904 13 - - HYPH cord-005453-4057qib7 8904 14 5.0 5.0 CD cord-005453-4057qib7 8904 15 ) ) -RRB- cord-005453-4057qib7 8904 16 . . . cord-005453-4057qib7 8905 1 TRANSPLANT transplant NN cord-005453-4057qib7 8906 1 OUT out RB cord-005453-4057qib7 8906 2 - - HYPH cord-005453-4057qib7 8906 3 COMES comes NN cord-005453-4057qib7 8906 4 : : : cord-005453-4057qib7 8907 1 EBV EBV NNP cord-005453-4057qib7 8907 2 - - HYPH cord-005453-4057qib7 8907 3 seropositive seropositive JJ cord-005453-4057qib7 8907 4 recipients recipient NNS cord-005453-4057qib7 8907 5 in in IN cord-005453-4057qib7 8907 6 comparison comparison NN cord-005453-4057qib7 8907 7 to to IN cord-005453-4057qib7 8907 8 EBV EBV NNP cord-005453-4057qib7 8907 9 - - HYPH cord-005453-4057qib7 8907 10 seronegative seronegative JJ cord-005453-4057qib7 8907 11 recipients recipient NNS cord-005453-4057qib7 8907 12 had have VBD cord-005453-4057qib7 8907 13 lower low JJR cord-005453-4057qib7 8907 14 OS os NN cord-005453-4057qib7 8907 15 ( ( -LRB- cord-005453-4057qib7 8907 16 85.4 85.4 CD cord-005453-4057qib7 8907 17 % % NN cord-005453-4057qib7 8907 18 vs vs IN cord-005453-4057qib7 8907 19 88.4 88.4 CD cord-005453-4057qib7 8907 20 % % NN cord-005453-4057qib7 8907 21 , , , cord-005453-4057qib7 8907 22 p=0.035 p=0.035 NNP cord-005453-4057qib7 8907 23 ) ) -RRB- cord-005453-4057qib7 8907 24 , , , cord-005453-4057qib7 8907 25 and and CC cord-005453-4057qib7 8907 26 higher high JJR cord-005453-4057qib7 8907 27 NRM NRM NNP cord-005453-4057qib7 8907 28 ( ( -LRB- cord-005453-4057qib7 8907 29 10.0 10.0 CD cord-005453-4057qib7 8907 30 % % NN cord-005453-4057qib7 8907 31 vs vs IN cord-005453-4057qib7 8907 32 6.4 6.4 CD cord-005453-4057qib7 8907 33 % % NN cord-005453-4057qib7 8907 34 , , , cord-005453-4057qib7 8907 35 p=0.018 p=0.018 NNP cord-005453-4057qib7 8907 36 ) ) -RRB- cord-005453-4057qib7 8907 37 . . . cord-005453-4057qib7 8908 1 No no DT cord-005453-4057qib7 8908 2 other other JJ cord-005453-4057qib7 8908 3 significant significant JJ cord-005453-4057qib7 8908 4 differences difference NNS cord-005453-4057qib7 8908 5 were be VBD cord-005453-4057qib7 8908 6 found find VBN cord-005453-4057qib7 8908 7 for for IN cord-005453-4057qib7 8908 8 : : : cord-005453-4057qib7 8908 9 RI RI NNP cord-005453-4057qib7 8908 10 , , , cord-005453-4057qib7 8908 11 RFS RFS NNP cord-005453-4057qib7 8908 12 , , , cord-005453-4057qib7 8908 13 and and CC cord-005453-4057qib7 8908 14 acute acute JJ cord-005453-4057qib7 8908 15 or or CC cord-005453-4057qib7 8908 16 chronic chronic JJ cord-005453-4057qib7 8908 17 GVHD GVHD NNP cord-005453-4057qib7 8908 18 with with IN cord-005453-4057qib7 8908 19 respect respect NN cord-005453-4057qib7 8908 20 to to IN cord-005453-4057qib7 8908 21 EBV EBV NNP cord-005453-4057qib7 8908 22 pretransplant pretransplant NN cord-005453-4057qib7 8908 23 serostatus serostatus NN cord-005453-4057qib7 8908 24 donor donor NN cord-005453-4057qib7 8908 25 and/or and/or CC cord-005453-4057qib7 8908 26 recipient recipient NN cord-005453-4057qib7 8908 27 . . . cord-005453-4057qib7 8909 1 MULTI multi JJ cord-005453-4057qib7 8909 2 - - JJ cord-005453-4057qib7 8909 3 VARIATE VARIATE NNP cord-005453-4057qib7 8909 4 ANALYSIS analysis NN cord-005453-4057qib7 8909 5 : : : cord-005453-4057qib7 8910 1 EBV EBV NNP cord-005453-4057qib7 8910 2 serostatus serostatus NNP cord-005453-4057qib7 8910 3 as as IN cord-005453-4057qib7 8910 4 a a DT cord-005453-4057qib7 8910 5 risk risk NN cord-005453-4057qib7 8910 6 factor factor NN cord-005453-4057qib7 8910 7 did do VBD cord-005453-4057qib7 8910 8 not not RB cord-005453-4057qib7 8910 9 reach reach VB cord-005453-4057qib7 8910 10 significance significance NN cord-005453-4057qib7 8910 11 , , , cord-005453-4057qib7 8910 12 while while IN cord-005453-4057qib7 8910 13 a a DT cord-005453-4057qib7 8910 14 trend trend NN cord-005453-4057qib7 8910 15 towards towards IN cord-005453-4057qib7 8910 16 higher high JJR cord-005453-4057qib7 8910 17 risk risk NN cord-005453-4057qib7 8910 18 of of IN cord-005453-4057qib7 8910 19 development development NN cord-005453-4057qib7 8910 20 of of IN cord-005453-4057qib7 8910 21 cGVHD cGVHD NNP cord-005453-4057qib7 8910 22 ( ( -LRB- cord-005453-4057qib7 8910 23 HR=1.31 HR=1.31 NNPS cord-005453-4057qib7 8910 24 ; ; : cord-005453-4057qib7 8910 25 95%CI 95%ci CD cord-005453-4057qib7 8910 26 0.97 0.97 CD cord-005453-4057qib7 8910 27 - - HYPH cord-005453-4057qib7 8910 28 1.78 1.78 CD cord-005453-4057qib7 8910 29 ; ; : cord-005453-4057qib7 8910 30 p=0.081 p=0.081 NNP cord-005453-4057qib7 8910 31 ) ) -RRB- cord-005453-4057qib7 8910 32 and and CC cord-005453-4057qib7 8910 33 better well JJR cord-005453-4057qib7 8910 34 survival survival NN cord-005453-4057qib7 8910 35 ( ( -LRB- cord-005453-4057qib7 8910 36 HR=0.78 HR=0.78 NNP cord-005453-4057qib7 8910 37 ; ; : cord-005453-4057qib7 8910 38 95%CI 95%ci CD cord-005453-4057qib7 8910 39 0.59 0.59 CD cord-005453-4057qib7 8910 40 - - HYPH cord-005453-4057qib7 8910 41 1.04 1.04 CD cord-005453-4057qib7 8910 42 ; ; : cord-005453-4057qib7 8910 43 p=0.087 p=0.087 NNP cord-005453-4057qib7 8910 44 ) ) -RRB- cord-005453-4057qib7 8910 45 in in IN cord-005453-4057qib7 8910 46 allo allo NN cord-005453-4057qib7 8910 47 - - HYPH cord-005453-4057qib7 8910 48 HSCT HSCT NNP cord-005453-4057qib7 8910 49 from from IN cord-005453-4057qib7 8910 50 EBV EBV NNP cord-005453-4057qib7 8910 51 - - HYPH cord-005453-4057qib7 8910 52 seropositive seropositive JJ cord-005453-4057qib7 8910 53 donors donor NNS cord-005453-4057qib7 8910 54 . . . cord-005453-4057qib7 8911 1 Allo Allo NNP cord-005453-4057qib7 8911 2 - - HYPH cord-005453-4057qib7 8911 3 HSCT HSCT NNP cord-005453-4057qib7 8911 4 in in IN cord-005453-4057qib7 8911 5 EBV EBV NNP cord-005453-4057qib7 8911 6 - - HYPH cord-005453-4057qib7 8911 7 seropositive seropositive JJ cord-005453-4057qib7 8911 8 recipients recipient NNS cord-005453-4057qib7 8911 9 had have VBD cord-005453-4057qib7 8911 10 a a DT cord-005453-4057qib7 8911 11 trend trend NN cord-005453-4057qib7 8911 12 towards towards IN cord-005453-4057qib7 8911 13 lower low JJR cord-005453-4057qib7 8911 14 risk risk NN cord-005453-4057qib7 8911 15 of of IN cord-005453-4057qib7 8911 16 development development NN cord-005453-4057qib7 8911 17 of of IN cord-005453-4057qib7 8911 18 cGVHD cGVHD NNP cord-005453-4057qib7 8911 19 ( ( -LRB- cord-005453-4057qib7 8911 20 HR=0.75 HR=0.75 NNP cord-005453-4057qib7 8911 21 ; ; : cord-005453-4057qib7 8911 22 95%CI 95%ci CD cord-005453-4057qib7 8911 23 0.56 0.56 CD cord-005453-4057qib7 8911 24 - - HYPH cord-005453-4057qib7 8911 25 1.02 1.02 CD cord-005453-4057qib7 8911 26 ; ; : cord-005453-4057qib7 8911 27 p=0.066 p=0.066 NNP cord-005453-4057qib7 8911 28 ) ) -RRB- cord-005453-4057qib7 8911 29 . . . cord-005453-4057qib7 8912 1 When when WRB cord-005453-4057qib7 8912 2 4 4 CD cord-005453-4057qib7 8912 3 subgroups subgroup NNS cord-005453-4057qib7 8912 4 ( ( -LRB- cord-005453-4057qib7 8912 5 R-/D- R-/D- NNPS cord-005453-4057qib7 8912 6 , , , cord-005453-4057qib7 8912 7 R-/ r-/ NN cord-005453-4057qib7 8912 8 D+ d+ NN cord-005453-4057qib7 8912 9 , , , cord-005453-4057qib7 8912 10 R+/D- R+/D- NNP cord-005453-4057qib7 8912 11 , , , cord-005453-4057qib7 8912 12 R+/D+ r+/d+ JJ cord-005453-4057qib7 8912 13 EBV EBV NNP cord-005453-4057qib7 8912 14 serology serology NN cord-005453-4057qib7 8912 15 ) ) -RRB- cord-005453-4057qib7 8912 16 were be VBD cord-005453-4057qib7 8912 17 analyzed analyze VBN cord-005453-4057qib7 8912 18 , , , cord-005453-4057qib7 8912 19 the the DT cord-005453-4057qib7 8912 20 EBV EBV NNP cord-005453-4057qib7 8912 21 serostatus serostatus NN cord-005453-4057qib7 8912 22 had have VBD cord-005453-4057qib7 8912 23 no no DT cord-005453-4057qib7 8912 24 significant significant JJ cord-005453-4057qib7 8912 25 impact impact NN cord-005453-4057qib7 8912 26 on on IN cord-005453-4057qib7 8912 27 OS OS NNP cord-005453-4057qib7 8912 28 , , , cord-005453-4057qib7 8912 29 RFS RFS NNP cord-005453-4057qib7 8912 30 , , , cord-005453-4057qib7 8912 31 RI RI NNP cord-005453-4057qib7 8912 32 , , , cord-005453-4057qib7 8912 33 TRM TRM NNP cord-005453-4057qib7 8912 34 and and CC cord-005453-4057qib7 8912 35 development development NN cord-005453-4057qib7 8912 36 of of IN cord-005453-4057qib7 8912 37 acute acute JJ cord-005453-4057qib7 8912 38 or or CC cord-005453-4057qib7 8912 39 chronic chronic JJ cord-005453-4057qib7 8912 40 GVHD GVHD NNP cord-005453-4057qib7 8912 41 . . . cord-005453-4057qib7 8913 1 Conclusions conclusion NNS cord-005453-4057qib7 8913 2 : : : cord-005453-4057qib7 8914 1 Allo Allo NNP cord-005453-4057qib7 8914 2 - - HYPH cord-005453-4057qib7 8914 3 HSCT HSCT NNP cord-005453-4057qib7 8914 4 from from IN cord-005453-4057qib7 8914 5 EBV EBV NNP cord-005453-4057qib7 8914 6 - - HYPH cord-005453-4057qib7 8914 7 seropositive seropositive JJ cord-005453-4057qib7 8914 8 vs vs IN cord-005453-4057qib7 8914 9 EBV EBV NNP cord-005453-4057qib7 8914 10 - - HYPH cord-005453-4057qib7 8914 11 seronegative seronegative JJ cord-005453-4057qib7 8914 12 donors donor NNS cord-005453-4057qib7 8914 13 are be VBP cord-005453-4057qib7 8914 14 at at IN cord-005453-4057qib7 8914 15 31 31 CD cord-005453-4057qib7 8914 16 % % NN cord-005453-4057qib7 8914 17 higher high JJR cord-005453-4057qib7 8914 18 risk risk NN cord-005453-4057qib7 8914 19 of of IN cord-005453-4057qib7 8914 20 chronic chronic JJ cord-005453-4057qib7 8914 21 GVHD GVHD NNP cord-005453-4057qib7 8914 22 in in IN cord-005453-4057qib7 8914 23 patients patient NNS cord-005453-4057qib7 8914 24 with with IN cord-005453-4057qib7 8914 25 non non JJ cord-005453-4057qib7 8914 26 - - JJ cord-005453-4057qib7 8914 27 malignant malignant JJ cord-005453-4057qib7 8914 28 hematological hematological JJ cord-005453-4057qib7 8914 29 disorders disorder NNS cord-005453-4057qib7 8914 30 undergoing undergo VBG cord-005453-4057qib7 8914 31 allo allo NN cord-005453-4057qib7 8914 32 - - HYPH cord-005453-4057qib7 8914 33 HSCT HSCT NNP cord-005453-4057qib7 8914 34 , , , cord-005453-4057qib7 8914 35 however however RB cord-005453-4057qib7 8914 36 this this DT cord-005453-4057qib7 8914 37 difference difference NN cord-005453-4057qib7 8914 38 is be VBZ cord-005453-4057qib7 8914 39 non non JJ cord-005453-4057qib7 8914 40 - - JJ cord-005453-4057qib7 8914 41 significant significant JJ cord-005453-4057qib7 8914 42 in in IN cord-005453-4057qib7 8914 43 multivariate multivariate JJ cord-005453-4057qib7 8914 44 analysis analysis NN cord-005453-4057qib7 8914 45 . . . cord-005453-4057qib7 8915 1 Disclosure disclosure NN cord-005453-4057qib7 8915 2 : : : cord-005453-4057qib7 8915 3 Nothing nothing NN cord-005453-4057qib7 8915 4 to to TO cord-005453-4057qib7 8915 5 declare declare VB cord-005453-4057qib7 8915 6 . . . cord-005453-4057qib7 8916 1 Results result NNS cord-005453-4057qib7 8916 2 : : : cord-005453-4057qib7 8917 1 Twenty twenty CD cord-005453-4057qib7 8917 2 - - HYPH cord-005453-4057qib7 8917 3 eight eight CD cord-005453-4057qib7 8917 4 ( ( -LRB- cord-005453-4057qib7 8917 5 30 30 CD cord-005453-4057qib7 8917 6 % % NN cord-005453-4057qib7 8917 7 ) ) -RRB- cord-005453-4057qib7 8917 8 pts pt NNS cord-005453-4057qib7 8917 9 ( ( -LRB- cord-005453-4057qib7 8917 10 19 19 CD cord-005453-4057qib7 8917 11 male male NN cord-005453-4057qib7 8917 12 , , , cord-005453-4057qib7 8917 13 9 9 CD cord-005453-4057qib7 8917 14 female female NN cord-005453-4057qib7 8917 15 ) ) -RRB- cord-005453-4057qib7 8917 16 were be VBD cord-005453-4057qib7 8917 17 tested test VBN cord-005453-4057qib7 8917 18 positive positive JJ cord-005453-4057qib7 8917 19 ( ( -LRB- cord-005453-4057qib7 8917 20 group group NN cord-005453-4057qib7 8917 21 1 1 CD cord-005453-4057qib7 8917 22 ) ) -RRB- cord-005453-4057qib7 8917 23 for for IN cord-005453-4057qib7 8917 24 subtype subtype NN cord-005453-4057qib7 8917 25 A a NN cord-005453-4057qib7 8917 26 ( ( -LRB- cord-005453-4057qib7 8917 27 n=4 n=4 JJ cord-005453-4057qib7 8917 28 , , , cord-005453-4057qib7 8917 29 14 14 CD cord-005453-4057qib7 8917 30 % % NN cord-005453-4057qib7 8917 31 ) ) -RRB- cord-005453-4057qib7 8917 32 , , , cord-005453-4057qib7 8917 33 B B NNP cord-005453-4057qib7 8917 34 ( ( -LRB- cord-005453-4057qib7 8917 35 n=18 n=18 CC cord-005453-4057qib7 8917 36 , , , cord-005453-4057qib7 8917 37 64 64 CD cord-005453-4057qib7 8917 38 % % NN cord-005453-4057qib7 8917 39 ) ) -RRB- cord-005453-4057qib7 8917 40 or or CC cord-005453-4057qib7 8917 41 A a DT cord-005453-4057qib7 8917 42 ( ( -LRB- cord-005453-4057qib7 8917 43 H1N1 H1N1 NNP cord-005453-4057qib7 8917 44 ) ) -RRB- cord-005453-4057qib7 8917 45 ( ( -LRB- cord-005453-4057qib7 8917 46 n=6 n=6 NNP cord-005453-4057qib7 8917 47 , , , cord-005453-4057qib7 8917 48 21 21 CD cord-005453-4057qib7 8917 49 % % NN cord-005453-4057qib7 8917 50 ) ) -RRB- cord-005453-4057qib7 8917 51 while while IN cord-005453-4057qib7 8917 52 67 67 CD cord-005453-4057qib7 8917 53 ( ( -LRB- cord-005453-4057qib7 8917 54 70 70 CD cord-005453-4057qib7 8917 55 % % NN cord-005453-4057qib7 8917 56 ) ) -RRB- cord-005453-4057qib7 8917 57 pts pts NN cord-005453-4057qib7 8917 58 ( ( -LRB- cord-005453-4057qib7 8917 59 32 32 CD cord-005453-4057qib7 8917 60 male male NN cord-005453-4057qib7 8917 61 , , , cord-005453-4057qib7 8917 62 35 35 CD cord-005453-4057qib7 8917 63 female female NN cord-005453-4057qib7 8917 64 ) ) -RRB- cord-005453-4057qib7 8917 65 were be VBD cord-005453-4057qib7 8917 66 negative negative JJ cord-005453-4057qib7 8917 67 ( ( -LRB- cord-005453-4057qib7 8917 68 group group NN cord-005453-4057qib7 8917 69 2 2 CD cord-005453-4057qib7 8917 70 ) ) -RRB- cord-005453-4057qib7 8917 71 . . . cord-005453-4057qib7 8918 1 Vaccination vaccination NN cord-005453-4057qib7 8918 2 rate rate NN cord-005453-4057qib7 8918 3 in in IN cord-005453-4057qib7 8918 4 group group NN cord-005453-4057qib7 8918 5 1 1 CD cord-005453-4057qib7 8918 6 ( ( -LRB- cord-005453-4057qib7 8918 7 32 32 CD cord-005453-4057qib7 8918 8 % % NN cord-005453-4057qib7 8918 9 ) ) -RRB- cord-005453-4057qib7 8918 10 was be VBD cord-005453-4057qib7 8918 11 significantly significantly RB cord-005453-4057qib7 8918 12 lower low JJR cord-005453-4057qib7 8918 13 compared compare VBN cord-005453-4057qib7 8918 14 to to IN cord-005453-4057qib7 8918 15 group group NN cord-005453-4057qib7 8918 16 2 2 CD cord-005453-4057qib7 8918 17 ( ( -LRB- cord-005453-4057qib7 8918 18 51 51 CD cord-005453-4057qib7 8918 19 % % NN cord-005453-4057qib7 8918 20 , , , cord-005453-4057qib7 8918 21 p=0.002 p=0.002 NNP cord-005453-4057qib7 8918 22 ) ) -RRB- cord-005453-4057qib7 8918 23 . . . cord-005453-4057qib7 8919 1 The the DT cord-005453-4057qib7 8919 2 median median JJ cord-005453-4057qib7 8919 3 time time NN cord-005453-4057qib7 8919 4 after after IN cord-005453-4057qib7 8919 5 transplantation transplantation NN cord-005453-4057qib7 8919 6 ( ( -LRB- cord-005453-4057qib7 8919 7 790 790 CD cord-005453-4057qib7 8919 8 vs vs IN cord-005453-4057qib7 8919 9 565 565 CD cord-005453-4057qib7 8919 10 days day NNS cord-005453-4057qib7 8919 11 ) ) -RRB- cord-005453-4057qib7 8919 12 , , , cord-005453-4057qib7 8919 13 T t NN cord-005453-4057qib7 8919 14 - - HYPH cord-005453-4057qib7 8919 15 cell cell NN cord-005453-4057qib7 8919 16 counts count NNS cord-005453-4057qib7 8919 17 ( ( -LRB- cord-005453-4057qib7 8919 18 349 349 CD cord-005453-4057qib7 8919 19 vs vs IN cord-005453-4057qib7 8919 20 296/ 296/ CD cord-005453-4057qib7 8919 21 μl μl NNP cord-005453-4057qib7 8919 22 ) ) -RRB- cord-005453-4057qib7 8919 23 , , , cord-005453-4057qib7 8919 24 Bcell Bcell NNP cord-005453-4057qib7 8919 25 counts count VBZ cord-005453-4057qib7 8919 26 ( ( -LRB- cord-005453-4057qib7 8919 27 162 162 CD cord-005453-4057qib7 8919 28 vs vs IN cord-005453-4057qib7 8919 29 135/ 135/ CD cord-005453-4057qib7 8919 30 μl μl NN cord-005453-4057qib7 8919 31 ) ) -RRB- cord-005453-4057qib7 8919 32 , , , cord-005453-4057qib7 8919 33 IgG igg NN cord-005453-4057qib7 8919 34 - - HYPH cord-005453-4057qib7 8919 35 level level NN cord-005453-4057qib7 8919 36 ( ( -LRB- cord-005453-4057qib7 8919 37 8,3 8,3 CD cord-005453-4057qib7 8919 38 vs vs IN cord-005453-4057qib7 8919 39 7,6 7,6 CD cord-005453-4057qib7 8919 40 g/ g/ NNP cord-005453-4057qib7 8919 41 l l NNP cord-005453-4057qib7 8919 42 ) ) -RRB- cord-005453-4057qib7 8919 43 , , , cord-005453-4057qib7 8919 44 proportion proportion NN cord-005453-4057qib7 8919 45 of of IN cord-005453-4057qib7 8919 46 immunosuppressed immunosuppressed JJ cord-005453-4057qib7 8919 47 pts pt NNS cord-005453-4057qib7 8919 48 ( ( -LRB- cord-005453-4057qib7 8919 49 75 75 CD cord-005453-4057qib7 8919 50 % % NN cord-005453-4057qib7 8919 51 vs vs IN cord-005453-4057qib7 8919 52 63 63 CD cord-005453-4057qib7 8919 53 % % NN cord-005453-4057qib7 8919 54 ) ) -RRB- cord-005453-4057qib7 8919 55 , , , cord-005453-4057qib7 8919 56 male/ male/ CD cord-005453-4057qib7 8919 57 female female JJ cord-005453-4057qib7 8919 58 ratio ratio NN cord-005453-4057qib7 8919 59 was be VBD cord-005453-4057qib7 8919 60 not not RB cord-005453-4057qib7 8919 61 significantly significantly RB cord-005453-4057qib7 8919 62 different different JJ cord-005453-4057qib7 8919 63 between between IN cord-005453-4057qib7 8919 64 groups group NNS cord-005453-4057qib7 8919 65 1 1 CD cord-005453-4057qib7 8919 66 and and CC cord-005453-4057qib7 8919 67 2 2 CD cord-005453-4057qib7 8919 68 . . . cord-005453-4057qib7 8920 1 Within within IN cord-005453-4057qib7 8920 2 group group NN cord-005453-4057qib7 8920 3 1 1 CD cord-005453-4057qib7 8920 4 influenza influenza NN cord-005453-4057qib7 8920 5 subtypes subtype NNS cord-005453-4057qib7 8920 6 were be VBD cord-005453-4057qib7 8920 7 similarly similarly RB cord-005453-4057qib7 8920 8 distributed distribute VBN cord-005453-4057qib7 8920 9 in in IN cord-005453-4057qib7 8920 10 vaccinated vaccinated JJ cord-005453-4057qib7 8920 11 and and CC cord-005453-4057qib7 8920 12 not not RB cord-005453-4057qib7 8920 13 vaccinated vaccinate VBN cord-005453-4057qib7 8920 14 pts pt NNS cord-005453-4057qib7 8920 15 ( ( -LRB- cord-005453-4057qib7 8920 16 A a DT cord-005453-4057qib7 8920 17 11 11 CD cord-005453-4057qib7 8920 18 % % NN cord-005453-4057qib7 8920 19 vs vs IN cord-005453-4057qib7 8920 20 16 16 CD cord-005453-4057qib7 8920 21 % % NN cord-005453-4057qib7 8920 22 , , , cord-005453-4057qib7 8920 23 B b NN cord-005453-4057qib7 8920 24 67 67 CD cord-005453-4057qib7 8920 25 % % NN cord-005453-4057qib7 8920 26 vs vs IN cord-005453-4057qib7 8920 27 63 63 CD cord-005453-4057qib7 8920 28 % % NN cord-005453-4057qib7 8920 29 , , , cord-005453-4057qib7 8920 30 A A NNP cord-005453-4057qib7 8920 31 ( ( -LRB- cord-005453-4057qib7 8920 32 H1N1 H1N1 NNP cord-005453-4057qib7 8920 33 ) ) -RRB- cord-005453-4057qib7 8921 1 22 22 CD cord-005453-4057qib7 8921 2 % % NN cord-005453-4057qib7 8921 3 vs vs IN cord-005453-4057qib7 8921 4 21 21 CD cord-005453-4057qib7 8921 5 % % NN cord-005453-4057qib7 8921 6 ) ) -RRB- cord-005453-4057qib7 8921 7 . . . cord-005453-4057qib7 8922 1 Pts Pts NNP cord-005453-4057qib7 8922 2 . . . cord-005453-4057qib7 8923 1 with with IN cord-005453-4057qib7 8923 2 subtype subtype NN cord-005453-4057qib7 8923 3 B b NN cord-005453-4057qib7 8923 4 infection infection NN cord-005453-4057qib7 8923 5 had have VBD cord-005453-4057qib7 8923 6 higher high JJR cord-005453-4057qib7 8923 7 levels level NNS cord-005453-4057qib7 8923 8 of of IN cord-005453-4057qib7 8923 9 T-(482 T-(482 NNP cord-005453-4057qib7 8923 10 vs vs IN cord-005453-4057qib7 8923 11 274/ 274/ CD cord-005453-4057qib7 8923 12 μl μl NNP cord-005453-4057qib7 8923 13 ) ) -RRB- cord-005453-4057qib7 8924 1 and and CC cord-005453-4057qib7 8924 2 B b NN cord-005453-4057qib7 8924 3 - - HYPH cord-005453-4057qib7 8924 4 cells cell NNS cord-005453-4057qib7 8924 5 ( ( -LRB- cord-005453-4057qib7 8924 6 232 232 CD cord-005453-4057qib7 8924 7 vs vs IN cord-005453-4057qib7 8924 8 108/ 108/ CD cord-005453-4057qib7 8924 9 μl μl NN cord-005453-4057qib7 8924 10 ) ) -RRB- cord-005453-4057qib7 8924 11 and and CC cord-005453-4057qib7 8924 12 a a DT cord-005453-4057qib7 8924 13 longer longer RB cord-005453-4057qib7 8924 14 follow follow VB cord-005453-4057qib7 8924 15 up up RP cord-005453-4057qib7 8924 16 from from IN cord-005453-4057qib7 8924 17 SCT SCT NNP cord-005453-4057qib7 8924 18 ( ( -LRB- cord-005453-4057qib7 8924 19 1610 1610 CD cord-005453-4057qib7 8924 20 vs vs IN cord-005453-4057qib7 8924 21 470 470 CD cord-005453-4057qib7 8924 22 days day NNS cord-005453-4057qib7 8924 23 ) ) -RRB- cord-005453-4057qib7 8924 24 compared compare VBN cord-005453-4057qib7 8924 25 to to IN cord-005453-4057qib7 8924 26 subtype subtype NN cord-005453-4057qib7 8924 27 A A NNP cord-005453-4057qib7 8924 28 / / SYM cord-005453-4057qib7 8924 29 A a NN cord-005453-4057qib7 8924 30 ( ( -LRB- cord-005453-4057qib7 8924 31 H1N1 H1N1 NNP cord-005453-4057qib7 8924 32 ) ) -RRB- cord-005453-4057qib7 8924 33 infection infection NN cord-005453-4057qib7 8924 34 but but CC cord-005453-4057qib7 8924 35 differences difference NNS cord-005453-4057qib7 8924 36 were be VBD cord-005453-4057qib7 8924 37 not not RB cord-005453-4057qib7 8924 38 significant significant JJ cord-005453-4057qib7 8924 39 . . . cord-005453-4057qib7 8925 1 Conclusions conclusion NNS cord-005453-4057qib7 8925 2 : : : cord-005453-4057qib7 8926 1 Influenza influenza NN cord-005453-4057qib7 8926 2 could could MD cord-005453-4057qib7 8926 3 be be VB cord-005453-4057qib7 8926 4 proven prove VBN cord-005453-4057qib7 8926 5 in in IN cord-005453-4057qib7 8926 6 one one CD cord-005453-4057qib7 8926 7 third third NN cord-005453-4057qib7 8926 8 of of IN cord-005453-4057qib7 8926 9 all all DT cord-005453-4057qib7 8926 10 tested test VBN cord-005453-4057qib7 8926 11 pts pt NNS cord-005453-4057qib7 8926 12 . . . cord-005453-4057qib7 8927 1 Dominance dominance NN cord-005453-4057qib7 8927 2 of of IN cord-005453-4057qib7 8927 3 B b NN cord-005453-4057qib7 8927 4 and and CC cord-005453-4057qib7 8927 5 A A NNP cord-005453-4057qib7 8927 6 ( ( -LRB- cord-005453-4057qib7 8927 7 H1N1 H1N1 NNP cord-005453-4057qib7 8927 8 ) ) -RRB- cord-005453-4057qib7 8927 9 pdm0e9 pdm0e9 NNP cord-005453-4057qib7 8927 10 subtype subtype NN cord-005453-4057qib7 8927 11 occurrence occurrence NN cord-005453-4057qib7 8927 12 corresponded correspond VBD cord-005453-4057qib7 8927 13 to to IN cord-005453-4057qib7 8927 14 the the DT cord-005453-4057qib7 8927 15 flu flu NN cord-005453-4057qib7 8927 16 epidemic epidemic NN cord-005453-4057qib7 8927 17 dissemination dissemination NN cord-005453-4057qib7 8927 18 in in IN cord-005453-4057qib7 8927 19 the the DT cord-005453-4057qib7 8927 20 German german JJ cord-005453-4057qib7 8927 21 population population NN cord-005453-4057qib7 8927 22 . . . cord-005453-4057qib7 8928 1 The the DT cord-005453-4057qib7 8928 2 most most RBS cord-005453-4057qib7 8928 3 important important JJ cord-005453-4057qib7 8928 4 protective protective JJ cord-005453-4057qib7 8928 5 factor factor NN cord-005453-4057qib7 8928 6 for for IN cord-005453-4057qib7 8928 7 outpatient outpatient NN cord-005453-4057qib7 8928 8 SCT SCT NNP cord-005453-4057qib7 8928 9 recipients recipient NNS cord-005453-4057qib7 8928 10 was be VBD cord-005453-4057qib7 8928 11 influenza influenza NN cord-005453-4057qib7 8928 12 vaccination vaccination NN cord-005453-4057qib7 8928 13 . . . cord-005453-4057qib7 8929 1 Disclosure disclosure NN cord-005453-4057qib7 8929 2 : : : cord-005453-4057qib7 8929 3 Nothing nothing NN cord-005453-4057qib7 8929 4 to to TO cord-005453-4057qib7 8929 5 declare declare VB cord-005453-4057qib7 8929 6 Background background NN cord-005453-4057qib7 8929 7 : : : cord-005453-4057qib7 8929 8 CMV CMV NNP cord-005453-4057qib7 8929 9 infection infection NN cord-005453-4057qib7 8929 10 is be VBZ cord-005453-4057qib7 8929 11 one one CD cord-005453-4057qib7 8929 12 of of IN cord-005453-4057qib7 8929 13 the the DT cord-005453-4057qib7 8929 14 most most RBS cord-005453-4057qib7 8929 15 frequent frequent JJ cord-005453-4057qib7 8929 16 complications complication NNS cord-005453-4057qib7 8929 17 after after IN cord-005453-4057qib7 8929 18 HAPLO HAPLO NNP cord-005453-4057qib7 8929 19 . . . cord-005453-4057qib7 8930 1 Some some DT cord-005453-4057qib7 8930 2 risk risk NN cord-005453-4057qib7 8930 3 factors factor NNS cord-005453-4057qib7 8930 4 are be VBP cord-005453-4057qib7 8930 5 well well RB cord-005453-4057qib7 8930 6 known know VBN cord-005453-4057qib7 8930 7 but but CC cord-005453-4057qib7 8930 8 the the DT cord-005453-4057qib7 8930 9 best good JJS cord-005453-4057qib7 8930 10 strategy strategy NN cord-005453-4057qib7 8930 11 ( ( -LRB- cord-005453-4057qib7 8930 12 prophylactic prophylactic JJ cord-005453-4057qib7 8930 13 or or CC cord-005453-4057qib7 8930 14 preemptive preemptive JJ cord-005453-4057qib7 8930 15 treatment treatment NN cord-005453-4057qib7 8930 16 ) ) -RRB- cord-005453-4057qib7 8930 17 to to TO cord-005453-4057qib7 8930 18 mitigate mitigate VB cord-005453-4057qib7 8930 19 this this DT cord-005453-4057qib7 8930 20 complication complication NN cord-005453-4057qib7 8930 21 is be VBZ cord-005453-4057qib7 8930 22 not not RB cord-005453-4057qib7 8930 23 still still RB cord-005453-4057qib7 8930 24 well well RB cord-005453-4057qib7 8930 25 defined define VBN cord-005453-4057qib7 8930 26 . . . cord-005453-4057qib7 8931 1 The the DT cord-005453-4057qib7 8931 2 primary primary JJ cord-005453-4057qib7 8931 3 endpoint endpoint NN cord-005453-4057qib7 8931 4 in in IN cord-005453-4057qib7 8931 5 our -PRON- PRP$ cord-005453-4057qib7 8931 6 study study NN cord-005453-4057qib7 8931 7 is be VBZ cord-005453-4057qib7 8931 8 to to TO cord-005453-4057qib7 8931 9 describe describe VB cord-005453-4057qib7 8931 10 incidence incidence NN cord-005453-4057qib7 8931 11 and and CC cord-005453-4057qib7 8931 12 risk risk NN cord-005453-4057qib7 8931 13 factors factor NNS cord-005453-4057qib7 8931 14 to to TO cord-005453-4057qib7 8931 15 develop develop VB cord-005453-4057qib7 8931 16 CMV CMV NNP cord-005453-4057qib7 8931 17 infection infection NN cord-005453-4057qib7 8931 18 or or CC cord-005453-4057qib7 8931 19 disease disease NN cord-005453-4057qib7 8931 20 in in IN cord-005453-4057qib7 8931 21 HAPLO HAPLO NNP cord-005453-4057qib7 8931 22 . . . cord-005453-4057qib7 8932 1 As as IN cord-005453-4057qib7 8932 2 secondary secondary JJ cord-005453-4057qib7 8932 3 objective objective NN cord-005453-4057qib7 8932 4 we -PRON- PRP cord-005453-4057qib7 8932 5 analyzed analyze VBD cord-005453-4057qib7 8932 6 efficacytoxicity efficacytoxicity NN cord-005453-4057qib7 8932 7 of of IN cord-005453-4057qib7 8932 8 treatment treatment NN cord-005453-4057qib7 8932 9 and and CC cord-005453-4057qib7 8932 10 CMV CMV NNP cord-005453-4057qib7 8932 11 related relate VBN cord-005453-4057qib7 8932 12 mortality mortality NN cord-005453-4057qib7 8932 13 . . . cord-005453-4057qib7 8933 1 Methods method NNS cord-005453-4057qib7 8933 2 : : : cord-005453-4057qib7 8933 3 We -PRON- PRP cord-005453-4057qib7 8933 4 analyzed analyze VBD cord-005453-4057qib7 8933 5 60 60 CD cord-005453-4057qib7 8933 6 patients patient NNS cord-005453-4057qib7 8933 7 who who WP cord-005453-4057qib7 8933 8 underwent undergo VBD cord-005453-4057qib7 8933 9 HAPLO HAPLO NNP cord-005453-4057qib7 8933 10 in in IN cord-005453-4057qib7 8933 11 our -PRON- PRP$ cord-005453-4057qib7 8933 12 center center NN cord-005453-4057qib7 8933 13 between between IN cord-005453-4057qib7 8933 14 May May NNP cord-005453-4057qib7 8933 15 2012 2012 CD cord-005453-4057qib7 8933 16 and and CC cord-005453-4057qib7 8933 17 May May NNP cord-005453-4057qib7 8933 18 2018 2018 CD cord-005453-4057qib7 8933 19 . . . cord-005453-4057qib7 8934 1 All all DT cord-005453-4057qib7 8934 2 of of IN cord-005453-4057qib7 8934 3 them -PRON- PRP cord-005453-4057qib7 8934 4 received receive VBD cord-005453-4057qib7 8934 5 PTCy PTCy NNS cord-005453-4057qib7 8934 6 ( ( -LRB- cord-005453-4057qib7 8934 7 D+3 d+3 VB cord-005453-4057qib7 8934 8 and and CC cord-005453-4057qib7 8934 9 D+4 D+4 NNP cord-005453-4057qib7 8934 10 ) ) -RRB- cord-005453-4057qib7 8934 11 , , , cord-005453-4057qib7 8934 12 tacrolimus tacrolimus NNP cord-005453-4057qib7 8934 13 and and CC cord-005453-4057qib7 8934 14 mycophenolate mycophenolate NNP cord-005453-4057qib7 8934 15 as as IN cord-005453-4057qib7 8934 16 graft graft NN cord-005453-4057qib7 8934 17 versus versus IN cord-005453-4057qib7 8934 18 host host NN cord-005453-4057qib7 8934 19 disease disease NN cord-005453-4057qib7 8934 20 prophylaxis prophylaxis NN cord-005453-4057qib7 8934 21 . . . cord-005453-4057qib7 8935 1 A a DT cord-005453-4057qib7 8935 2 preemptive preemptive JJ cord-005453-4057qib7 8935 3 therapy therapy NN cord-005453-4057qib7 8935 4 based base VBN cord-005453-4057qib7 8935 5 on on IN cord-005453-4057qib7 8935 6 viral viral JJ cord-005453-4057qib7 8935 7 load load NN cord-005453-4057qib7 8935 8 was be VBD cord-005453-4057qib7 8935 9 applied apply VBN cord-005453-4057qib7 8935 10 . . . cord-005453-4057qib7 8936 1 Treatment treatment NN cord-005453-4057qib7 8936 2 was be VBD cord-005453-4057qib7 8936 3 started start VBN cord-005453-4057qib7 8936 4 when when WRB cord-005453-4057qib7 8936 5 > > XX cord-005453-4057qib7 8936 6 1000 1000 CD cord-005453-4057qib7 8936 7 UI UI NNP cord-005453-4057qib7 8936 8 / / SYM cord-005453-4057qib7 8936 9 mL ml NN cord-005453-4057qib7 8936 10 of of IN cord-005453-4057qib7 8936 11 CMV CMV NNP cord-005453-4057qib7 8936 12 were be VBD cord-005453-4057qib7 8936 13 detected detect VBN cord-005453-4057qib7 8936 14 in in IN cord-005453-4057qib7 8936 15 one one CD cord-005453-4057qib7 8936 16 determination determination NN cord-005453-4057qib7 8936 17 or or CC cord-005453-4057qib7 8936 18 > > XX cord-005453-4057qib7 8936 19 500 500 CD cord-005453-4057qib7 8936 20 UI UI NNP cord-005453-4057qib7 8936 21 / / SYM cord-005453-4057qib7 8936 22 mL ml NN cord-005453-4057qib7 8936 23 in in IN cord-005453-4057qib7 8936 24 two two CD cord-005453-4057qib7 8936 25 consecutive consecutive JJ cord-005453-4057qib7 8936 26 determinations determination NNS cord-005453-4057qib7 8936 27 . . . cord-005453-4057qib7 8937 1 CMV CMV NNP cord-005453-4057qib7 8937 2 analyses analysis NNS cord-005453-4057qib7 8937 3 were be VBD cord-005453-4057qib7 8937 4 made make VBN cord-005453-4057qib7 8937 5 in in IN cord-005453-4057qib7 8937 6 plasma plasma NN cord-005453-4057qib7 8937 7 using use VBG cord-005453-4057qib7 8937 8 Cobas Cobas NNP cord-005453-4057qib7 8937 9 PCR PCR NNP cord-005453-4057qib7 8937 10 technique technique NN cord-005453-4057qib7 8937 11 ® ® NN cord-005453-4057qib7 8937 12 and and CC cord-005453-4057qib7 8938 1 positive positive JJ cord-005453-4057qib7 8938 2 viral viral JJ cord-005453-4057qib7 8938 3 load load NN cord-005453-4057qib7 8938 4 cut cut VBN cord-005453-4057qib7 8938 5 - - HYPH cord-005453-4057qib7 8938 6 off off RP cord-005453-4057qib7 8938 7 point point NN cord-005453-4057qib7 8938 8 was be VBD cord-005453-4057qib7 8938 9 137 137 CD cord-005453-4057qib7 8938 10 UI UI NNP cord-005453-4057qib7 8938 11 / / SYM cord-005453-4057qib7 8938 12 mL. ml. NN cord-005453-4057qib7 8939 1 The the DT cord-005453-4057qib7 8939 2 CMV CMV NNP cord-005453-4057qib7 8939 3 viremia viremia NN cord-005453-4057qib7 8939 4 was be VBD cord-005453-4057qib7 8939 5 determined determine VBN cord-005453-4057qib7 8939 6 weekly weekly NN cord-005453-4057qib7 8939 7 until until IN cord-005453-4057qib7 8939 8 D+100 D+100 NNS cord-005453-4057qib7 8939 9 and and CC cord-005453-4057qib7 8939 10 then then RB cord-005453-4057qib7 8939 11 every every DT cord-005453-4057qib7 8939 12 two two CD cord-005453-4057qib7 8939 13 weeks week NNS cord-005453-4057qib7 8939 14 until until IN cord-005453-4057qib7 8939 15 immune immune JJ cord-005453-4057qib7 8939 16 reconstitution reconstitution NN cord-005453-4057qib7 8939 17 . . . cord-005453-4057qib7 8940 1 Results result NNS cord-005453-4057qib7 8940 2 : : : cord-005453-4057qib7 8941 1 The the DT cord-005453-4057qib7 8941 2 CMV CMV NNP cord-005453-4057qib7 8941 3 infection infection NN cord-005453-4057qib7 8941 4 and and CC cord-005453-4057qib7 8941 5 disease disease NN cord-005453-4057qib7 8941 6 incidence incidence NN cord-005453-4057qib7 8941 7 at at IN cord-005453-4057qib7 8941 8 D D NNP cord-005453-4057qib7 8941 9 +100 +100 NNP cord-005453-4057qib7 8941 10 was be VBD cord-005453-4057qib7 8941 11 61.3 61.3 CD cord-005453-4057qib7 8941 12 % % NN cord-005453-4057qib7 8941 13 ( ( -LRB- cord-005453-4057qib7 8941 14 38 38 CD cord-005453-4057qib7 8941 15 episodes episode NNS cord-005453-4057qib7 8941 16 ) ) -RRB- cord-005453-4057qib7 8941 17 and and CC cord-005453-4057qib7 8941 18 19.4 19.4 CD cord-005453-4057qib7 8941 19 % % NN cord-005453-4057qib7 8941 20 ( ( -LRB- cord-005453-4057qib7 8941 21 12 12 CD cord-005453-4057qib7 8941 22 episodes episode NNS cord-005453-4057qib7 8941 23 ) ) -RRB- cord-005453-4057qib7 8941 24 , , , cord-005453-4057qib7 8941 25 respectively respectively RB cord-005453-4057qib7 8941 26 . . . cord-005453-4057qib7 8942 1 CMV CMV NNP cord-005453-4057qib7 8942 2 disease disease NN cord-005453-4057qib7 8942 3 was be VBD cord-005453-4057qib7 8942 4 digestive digestive JJ cord-005453-4057qib7 8942 5 ( ( -LRB- cord-005453-4057qib7 8942 6 n=8 n=8 NN cord-005453-4057qib7 8942 7 ) ) -RRB- cord-005453-4057qib7 8942 8 , , , cord-005453-4057qib7 8942 9 pulmonar pulmonar NNP cord-005453-4057qib7 8942 10 ( ( -LRB- cord-005453-4057qib7 8942 11 n=2 n=2 NNP cord-005453-4057qib7 8942 12 ) ) -RRB- cord-005453-4057qib7 8942 13 , , , cord-005453-4057qib7 8942 14 neurologic neurologic JJ cord-005453-4057qib7 8942 15 ( ( -LRB- cord-005453-4057qib7 8942 16 n=1 n=1 FW cord-005453-4057qib7 8942 17 ) ) -RRB- cord-005453-4057qib7 8942 18 and and CC cord-005453-4057qib7 8942 19 disseminated disseminate VBN cord-005453-4057qib7 8942 20 ( ( -LRB- cord-005453-4057qib7 8942 21 n=1 n=1 CD cord-005453-4057qib7 8942 22 ) ) -RRB- cord-005453-4057qib7 8942 23 . . . cord-005453-4057qib7 8943 1 The the DT cord-005453-4057qib7 8943 2 median median JJ cord-005453-4057qib7 8943 3 time time NN cord-005453-4057qib7 8943 4 to to IN cord-005453-4057qib7 8943 5 first first JJ cord-005453-4057qib7 8943 6 CMV CMV NNP cord-005453-4057qib7 8943 7 infection infection NN cord-005453-4057qib7 8943 8 was be VBD cord-005453-4057qib7 8943 9 39.5 39.5 CD cord-005453-4057qib7 8943 10 days day NNS cord-005453-4057qib7 8943 11 ( ( -LRB- cord-005453-4057qib7 8943 12 20 20 CD cord-005453-4057qib7 8943 13 - - SYM cord-005453-4057qib7 8943 14 151 151 CD cord-005453-4057qib7 8943 15 ) ) -RRB- cord-005453-4057qib7 8943 16 . . . cord-005453-4057qib7 8944 1 Thirty thirty CD cord-005453-4057qib7 8944 2 - - HYPH cord-005453-4057qib7 8944 3 six six CD cord-005453-4057qib7 8944 4 patients patient NNS cord-005453-4057qib7 8944 5 had have VBD cord-005453-4057qib7 8944 6 at at RB cord-005453-4057qib7 8944 7 least least RBS cord-005453-4057qib7 8944 8 one one CD cord-005453-4057qib7 8944 9 episode episode NN cord-005453-4057qib7 8944 10 of of IN cord-005453-4057qib7 8944 11 CMV CMV NNP cord-005453-4057qib7 8944 12 infection infection NN cord-005453-4057qib7 8944 13 : : : cord-005453-4057qib7 8944 14 24 24 CD cord-005453-4057qib7 8944 15 of of IN cord-005453-4057qib7 8944 16 them -PRON- PRP cord-005453-4057qib7 8944 17 ( ( -LRB- cord-005453-4057qib7 8944 18 66.7 66.7 CD cord-005453-4057qib7 8944 19 % % NN cord-005453-4057qib7 8944 20 ) ) -RRB- cord-005453-4057qib7 8944 21 had have VBD cord-005453-4057qib7 8944 22 one one CD cord-005453-4057qib7 8944 23 episode episode NN cord-005453-4057qib7 8944 24 , , , cord-005453-4057qib7 8944 25 7 7 CD cord-005453-4057qib7 8944 26 ( ( -LRB- cord-005453-4057qib7 8944 27 19.4 19.4 CD cord-005453-4057qib7 8944 28 % % NN cord-005453-4057qib7 8944 29 ) ) -RRB- cord-005453-4057qib7 8944 30 had have VBD cord-005453-4057qib7 8944 31 two two CD cord-005453-4057qib7 8944 32 episodes episode NNS cord-005453-4057qib7 8944 33 and and CC cord-005453-4057qib7 8944 34 5 5 CD cord-005453-4057qib7 8944 35 ( ( -LRB- cord-005453-4057qib7 8944 36 13.9 13.9 CD cord-005453-4057qib7 8944 37 % % NN cord-005453-4057qib7 8944 38 ) ) -RRB- cord-005453-4057qib7 8944 39 had have VBD cord-005453-4057qib7 8944 40 3 3 CD cord-005453-4057qib7 8944 41 or or CC cord-005453-4057qib7 8944 42 more more JJR cord-005453-4057qib7 8944 43 episodes episode NNS cord-005453-4057qib7 8944 44 , , , cord-005453-4057qib7 8944 45 respectively respectively RB cord-005453-4057qib7 8944 46 . . . cord-005453-4057qib7 8945 1 Only only RB cord-005453-4057qib7 8945 2 pre pre JJ cord-005453-4057qib7 8945 3 - - JJ cord-005453-4057qib7 8945 4 transplantation transplantation JJ cord-005453-4057qib7 8945 5 CMV CMV NNP cord-005453-4057qib7 8945 6 status status NN cord-005453-4057qib7 8945 7 was be VBD cord-005453-4057qib7 8945 8 significantly significantly RB cord-005453-4057qib7 8945 9 associated associate VBN cord-005453-4057qib7 8945 10 with with IN cord-005453-4057qib7 8945 11 CMV CMV NNP cord-005453-4057qib7 8945 12 infection infection NN cord-005453-4057qib7 8945 13 ( ( -LRB- cord-005453-4057qib7 8945 14 p p NN cord-005453-4057qib7 8945 15 < < XX cord-005453-4057qib7 8945 16 0.001 0.001 CD cord-005453-4057qib7 8945 17 ) ) -RRB- cord-005453-4057qib7 8945 18 . . . cord-005453-4057qib7 8946 1 Risk risk NN cord-005453-4057qib7 8946 2 factors factor NNS cord-005453-4057qib7 8946 3 are be VBP cord-005453-4057qib7 8946 4 shown show VBN cord-005453-4057qib7 8946 5 in in IN cord-005453-4057qib7 8946 6 image image NN cord-005453-4057qib7 8946 7 1 1 CD cord-005453-4057qib7 8946 8 . . . cord-005453-4057qib7 8947 1 The the DT cord-005453-4057qib7 8947 2 median median JJ cord-005453-4057qib7 8947 3 viral viral JJ cord-005453-4057qib7 8947 4 load load NN cord-005453-4057qib7 8947 5 in in IN cord-005453-4057qib7 8947 6 first first JJ cord-005453-4057qib7 8947 7 CMV CMV NNP cord-005453-4057qib7 8947 8 infection infection NN cord-005453-4057qib7 8947 9 and and CC cord-005453-4057qib7 8947 10 disease disease NN cord-005453-4057qib7 8947 11 was be VBD cord-005453-4057qib7 8947 12 8314 8314 CD cord-005453-4057qib7 8947 13 UI UI NNP cord-005453-4057qib7 8947 14 / / SYM cord-005453-4057qib7 8947 15 mL ml NN cord-005453-4057qib7 8947 16 ( ( -LRB- cord-005453-4057qib7 8947 17 542 542 CD cord-005453-4057qib7 8947 18 - - SYM cord-005453-4057qib7 8947 19 51158 51158 CD cord-005453-4057qib7 8947 20 ) ) -RRB- cord-005453-4057qib7 8947 21 and and CC cord-005453-4057qib7 8947 22 24842 24842 CD cord-005453-4057qib7 8947 23 UI UI NNP cord-005453-4057qib7 8947 24 / / SYM cord-005453-4057qib7 8947 25 ml ml NN cord-005453-4057qib7 8947 26 ( ( -LRB- cord-005453-4057qib7 8947 27 271 271 CD cord-005453-4057qib7 8947 28 - - HYPH cord-005453-4057qib7 8947 29 126279 126279 CD cord-005453-4057qib7 8947 30 ) ) -RRB- cord-005453-4057qib7 8947 31 , , , cord-005453-4057qib7 8947 32 respectively respectively RB cord-005453-4057qib7 8947 33 ( ( -LRB- cord-005453-4057qib7 8947 34 p=0.02).The p=0.02).The NNP cord-005453-4057qib7 8947 35 median median JJ cord-005453-4057qib7 8947 36 counts count NNS cord-005453-4057qib7 8947 37 of of IN cord-005453-4057qib7 8947 38 CD4 CD4 NNP cord-005453-4057qib7 8947 39 lymphocytes lymphocyte VBZ cord-005453-4057qib7 8947 40 at at IN cord-005453-4057qib7 8947 41 D+100 D+100 NNS cord-005453-4057qib7 8947 42 in in IN cord-005453-4057qib7 8947 43 CMV CMV NNP cord-005453-4057qib7 8947 44 infection infection NN cord-005453-4057qib7 8947 45 and and CC cord-005453-4057qib7 8947 46 disease disease NN cord-005453-4057qib7 8947 47 were be VBD cord-005453-4057qib7 8947 48 262 262 CD cord-005453-4057qib7 8947 49 / / SYM cord-005453-4057qib7 8947 50 mm3 mm3 NNS cord-005453-4057qib7 8947 51 and and CC cord-005453-4057qib7 8947 52 120 120 CD cord-005453-4057qib7 8947 53 / / SYM cord-005453-4057qib7 8947 54 mm3 mm3 NNS cord-005453-4057qib7 8947 55 , , , cord-005453-4057qib7 8947 56 respectively respectively RB cord-005453-4057qib7 8947 57 ( ( -LRB- cord-005453-4057qib7 8947 58 p=0.09 p=0.09 NN cord-005453-4057qib7 8947 59 ) ) -RRB- cord-005453-4057qib7 8947 60 . . . cord-005453-4057qib7 8948 1 Preemptive preemptive JJ cord-005453-4057qib7 8948 2 therapy therapy NN cord-005453-4057qib7 8948 3 for for IN cord-005453-4057qib7 8948 4 the the DT cord-005453-4057qib7 8948 5 first first JJ cord-005453-4057qib7 8948 6 2 2 CD cord-005453-4057qib7 8948 7 episodes episode NNS cord-005453-4057qib7 8948 8 of of IN cord-005453-4057qib7 8948 9 CMV CMV NNP cord-005453-4057qib7 8948 10 infections infection NNS cord-005453-4057qib7 8948 11 ( ( -LRB- cord-005453-4057qib7 8948 12 n=48 n=48 NN cord-005453-4057qib7 8948 13 ) ) -RRB- cord-005453-4057qib7 8948 14 was be VBD cord-005453-4057qib7 8948 15 valganciclovir valganciclovir NNP cord-005453-4057qib7 8948 16 ( ( -LRB- cord-005453-4057qib7 8948 17 58,3 58,3 CD cord-005453-4057qib7 8948 18 % % NN cord-005453-4057qib7 8948 19 ) ) -RRB- cord-005453-4057qib7 8948 20 , , , cord-005453-4057qib7 8948 21 ganciclovir ganciclovir FW cord-005453-4057qib7 8948 22 ( ( -LRB- cord-005453-4057qib7 8948 23 35.4 35.4 CD cord-005453-4057qib7 8948 24 % % NN cord-005453-4057qib7 8948 25 ) ) -RRB- cord-005453-4057qib7 8948 26 or or CC cord-005453-4057qib7 8948 27 foscarnet foscarnet NN cord-005453-4057qib7 8948 28 ( ( -LRB- cord-005453-4057qib7 8948 29 6.3 6.3 CD cord-005453-4057qib7 8948 30 % % NN cord-005453-4057qib7 8948 31 ) ) -RRB- cord-005453-4057qib7 8948 32 , , , cord-005453-4057qib7 8948 33 reaching reach VBG cord-005453-4057qib7 8948 34 a a DT cord-005453-4057qib7 8948 35 complete complete JJ cord-005453-4057qib7 8948 36 viral viral JJ cord-005453-4057qib7 8948 37 load load NN cord-005453-4057qib7 8948 38 clearance clearance NN cord-005453-4057qib7 8948 39 in in IN cord-005453-4057qib7 8948 40 77 77 CD cord-005453-4057qib7 8948 41 % % NN cord-005453-4057qib7 8948 42 , , , cord-005453-4057qib7 8948 43 with with IN cord-005453-4057qib7 8948 44 a a DT cord-005453-4057qib7 8948 45 median median JJ cord-005453-4057qib7 8948 46 time time NN cord-005453-4057qib7 8948 47 to to IN cord-005453-4057qib7 8948 48 response response NN cord-005453-4057qib7 8948 49 of of IN cord-005453-4057qib7 8948 50 19.2 19.2 CD cord-005453-4057qib7 8948 51 days day NNS cord-005453-4057qib7 8948 52 ( ( -LRB- cord-005453-4057qib7 8948 53 6 6 CD cord-005453-4057qib7 8948 54 - - SYM cord-005453-4057qib7 8948 55 34 34 CD cord-005453-4057qib7 8948 56 ) ) -RRB- cord-005453-4057qib7 8948 57 and and CC cord-005453-4057qib7 8948 58 a a DT cord-005453-4057qib7 8948 59 median median JJ cord-005453-4057qib7 8948 60 treatment treatment NN cord-005453-4057qib7 8948 61 duration duration NN cord-005453-4057qib7 8948 62 of of IN cord-005453-4057qib7 8948 63 21 21 CD cord-005453-4057qib7 8948 64 days day NNS cord-005453-4057qib7 8948 65 ( ( -LRB- cord-005453-4057qib7 8948 66 2 2 CD cord-005453-4057qib7 8948 67 - - SYM cord-005453-4057qib7 8948 68 39 39 CD cord-005453-4057qib7 8948 69 ) ) -RRB- cord-005453-4057qib7 8948 70 . . . cord-005453-4057qib7 8949 1 Grade grade NN cord-005453-4057qib7 8949 2 III III NNP cord-005453-4057qib7 8949 3 - - HYPH cord-005453-4057qib7 8949 4 IV IV NNP cord-005453-4057qib7 8949 5 toxicity toxicity NN cord-005453-4057qib7 8949 6 ( ( -LRB- cord-005453-4057qib7 8949 7 mainly mainly RB cord-005453-4057qib7 8949 8 hematologic hematologic JJ cord-005453-4057qib7 8949 9 ) ) -RRB- cord-005453-4057qib7 8949 10 was be VBD cord-005453-4057qib7 8949 11 observed observe VBN cord-005453-4057qib7 8949 12 in in IN cord-005453-4057qib7 8949 13 55.6 55.6 CD cord-005453-4057qib7 8949 14 % % NN cord-005453-4057qib7 8949 15 ( ( -LRB- cord-005453-4057qib7 8949 16 n=28 n=28 RB cord-005453-4057qib7 8949 17 ) ) -RRB- cord-005453-4057qib7 8949 18 , , , cord-005453-4057qib7 8949 19 30 30 CD cord-005453-4057qib7 8949 20 % % NN cord-005453-4057qib7 8949 21 ( ( -LRB- cord-005453-4057qib7 8949 22 n=17 n=17 NNP cord-005453-4057qib7 8949 23 ) ) -RRB- cord-005453-4057qib7 8949 24 and and CC cord-005453-4057qib7 8949 25 16.7 16.7 CD cord-005453-4057qib7 8949 26 % % NN cord-005453-4057qib7 8949 27 ( ( -LRB- cord-005453-4057qib7 8949 28 n=3 n=3 NN cord-005453-4057qib7 8949 29 ) ) -RRB- cord-005453-4057qib7 8949 30 , , , cord-005453-4057qib7 8949 31 respectively respectively RB cord-005453-4057qib7 8949 32 . . . cord-005453-4057qib7 8950 1 Three three CD cord-005453-4057qib7 8950 2 patients patient NNS cord-005453-4057qib7 8950 3 had have VBD cord-005453-4057qib7 8950 4 an an DT cord-005453-4057qib7 8950 5 UL54 UL54 NNP cord-005453-4057qib7 8950 6 mutation mutation NN cord-005453-4057qib7 8950 7 , , , cord-005453-4057qib7 8950 8 one one CD cord-005453-4057qib7 8950 9 of of IN cord-005453-4057qib7 8950 10 them -PRON- PRP cord-005453-4057qib7 8950 11 with with IN cord-005453-4057qib7 8950 12 clinical clinical JJ cord-005453-4057qib7 8950 13 and and CC cord-005453-4057qib7 8950 14 microbiological microbiological JJ cord-005453-4057qib7 8950 15 resistance resistance NN cord-005453-4057qib7 8950 16 to to IN cord-005453-4057qib7 8950 17 the the DT cord-005453-4057qib7 8950 18 3 3 CD cord-005453-4057qib7 8950 19 mentioned mention VBD cord-005453-4057qib7 8950 20 drugs drug NNS cord-005453-4057qib7 8950 21 . . . cord-005453-4057qib7 8951 1 Three three CD cord-005453-4057qib7 8951 2 patients patient NNS cord-005453-4057qib7 8951 3 ( ( -LRB- cord-005453-4057qib7 8951 4 5 5 CD cord-005453-4057qib7 8951 5 % % NN cord-005453-4057qib7 8951 6 ) ) -RRB- cord-005453-4057qib7 8951 7 had have VBD cord-005453-4057qib7 8951 8 a a DT cord-005453-4057qib7 8951 9 graft graft NN cord-005453-4057qib7 8951 10 failure failure NN cord-005453-4057qib7 8951 11 secondary secondary JJ cord-005453-4057qib7 8951 12 to to IN cord-005453-4057qib7 8951 13 CMV CMV NNP cord-005453-4057qib7 8951 14 infections infection NNS cord-005453-4057qib7 8951 15 . . . cord-005453-4057qib7 8952 1 Five five CD cord-005453-4057qib7 8952 2 patients patient NNS cord-005453-4057qib7 8952 3 ( ( -LRB- cord-005453-4057qib7 8952 4 8.3 8.3 CD cord-005453-4057qib7 8952 5 % % NN cord-005453-4057qib7 8952 6 ) ) -RRB- cord-005453-4057qib7 8952 7 died die VBD cord-005453-4057qib7 8952 8 as as IN cord-005453-4057qib7 8952 9 consequence consequence NN cord-005453-4057qib7 8952 10 of of IN cord-005453-4057qib7 8952 11 CMV CMV NNP cord-005453-4057qib7 8952 12 infection infection NN cord-005453-4057qib7 8952 13 : : : cord-005453-4057qib7 8952 14 3 3 CD cord-005453-4057qib7 8952 15 before before IN cord-005453-4057qib7 8952 16 D+100 D+100 NNS cord-005453-4057qib7 8952 17 secondary secondary JJ cord-005453-4057qib7 8952 18 to to IN cord-005453-4057qib7 8952 19 CMV CMV NNP cord-005453-4057qib7 8952 20 disease disease NN cord-005453-4057qib7 8952 21 ( ( -LRB- cord-005453-4057qib7 8952 22 2 2 CD cord-005453-4057qib7 8952 23 pulmonar pulmonar NNP cord-005453-4057qib7 8952 24 , , , cord-005453-4057qib7 8952 25 1 1 CD cord-005453-4057qib7 8952 26 disseminated disseminate VBD cord-005453-4057qib7 8952 27 ) ) -RRB- cord-005453-4057qib7 8952 28 and and CC cord-005453-4057qib7 8952 29 2 2 CD cord-005453-4057qib7 8952 30 after after IN cord-005453-4057qib7 8952 31 D+365 D+365 NNS cord-005453-4057qib7 8952 32 due due IN cord-005453-4057qib7 8952 33 to to IN cord-005453-4057qib7 8952 34 graft graft NN cord-005453-4057qib7 8952 35 failure failure NN cord-005453-4057qib7 8952 36 and and CC cord-005453-4057qib7 8952 37 infectious infectious JJ cord-005453-4057qib7 8952 38 complications complication NNS cord-005453-4057qib7 8952 39 . . . cord-005453-4057qib7 8953 1 With with IN cord-005453-4057qib7 8953 2 a a DT cord-005453-4057qib7 8953 3 median median NN cord-005453-4057qib7 8953 4 follow follow NN cord-005453-4057qib7 8953 5 up up IN cord-005453-4057qib7 8953 6 of of IN cord-005453-4057qib7 8953 7 12.5 12.5 CD cord-005453-4057qib7 8953 8 months month NNS cord-005453-4057qib7 8953 9 , , , cord-005453-4057qib7 8953 10 overall overall JJ cord-005453-4057qib7 8953 11 survival survival NN cord-005453-4057qib7 8953 12 at at IN cord-005453-4057qib7 8953 13 18 18 CD cord-005453-4057qib7 8953 14 months month NNS cord-005453-4057qib7 8953 15 for for IN cord-005453-4057qib7 8953 16 patients patient NNS cord-005453-4057qib7 8953 17 who who WP cord-005453-4057qib7 8953 18 had have VBD cord-005453-4057qib7 8953 19 CMV CMV NNP cord-005453-4057qib7 8953 20 infection infection NN cord-005453-4057qib7 8953 21 was be VBD cord-005453-4057qib7 8953 22 58.9 58.9 CD cord-005453-4057qib7 8953 23 % % NN cord-005453-4057qib7 8953 24 compared compare VBN cord-005453-4057qib7 8953 25 to to IN cord-005453-4057qib7 8953 26 66.5 66.5 CD cord-005453-4057qib7 8953 27 % % NN cord-005453-4057qib7 8953 28 for for IN cord-005453-4057qib7 8953 29 those those DT cord-005453-4057qib7 8953 30 who who WP cord-005453-4057qib7 8953 31 had have VBD cord-005453-4057qib7 8953 32 no no DT cord-005453-4057qib7 8953 33 infection infection NN cord-005453-4057qib7 8953 34 ( ( -LRB- cord-005453-4057qib7 8953 35 p=0.08 p=0.08 NNP cord-005453-4057qib7 8953 36 ) ) -RRB- cord-005453-4057qib7 8953 37 . . . cord-005453-4057qib7 8954 1 Conclusions conclusion NNS cord-005453-4057qib7 8954 2 : : : cord-005453-4057qib7 8955 1 A a DT cord-005453-4057qib7 8955 2 high high JJ cord-005453-4057qib7 8955 3 incidence incidence NN cord-005453-4057qib7 8955 4 of of IN cord-005453-4057qib7 8955 5 CMV CMV NNP cord-005453-4057qib7 8955 6 infection infection NN cord-005453-4057qib7 8955 7 in in IN cord-005453-4057qib7 8955 8 HAPLO HAPLO NNP cord-005453-4057qib7 8955 9 with with IN cord-005453-4057qib7 8955 10 PTCy PTCy NNS cord-005453-4057qib7 8955 11 was be VBD cord-005453-4057qib7 8955 12 shown show VBN cord-005453-4057qib7 8955 13 in in IN cord-005453-4057qib7 8955 14 our -PRON- PRP$ cord-005453-4057qib7 8955 15 series series NN cord-005453-4057qib7 8955 16 and and CC cord-005453-4057qib7 8955 17 it -PRON- PRP cord-005453-4057qib7 8955 18 contributed contribute VBD cord-005453-4057qib7 8955 19 to to IN cord-005453-4057qib7 8955 20 mortality mortality NN cord-005453-4057qib7 8955 21 in in IN cord-005453-4057qib7 8955 22 8.3 8.3 CD cord-005453-4057qib7 8955 23 % % NN cord-005453-4057qib7 8955 24 of of IN cord-005453-4057qib7 8955 25 patients patient NNS cord-005453-4057qib7 8955 26 . . . cord-005453-4057qib7 8956 1 Only only RB cord-005453-4057qib7 8956 2 CMV CMV NNP cord-005453-4057qib7 8956 3 status status NN cord-005453-4057qib7 8956 4 ( ( -LRB- cord-005453-4057qib7 8956 5 D-/R+ D-/R+ NNP cord-005453-4057qib7 8956 6 and and CC cord-005453-4057qib7 8956 7 D+/R+ D+/R+ NNP cord-005453-4057qib7 8956 8 ) ) -RRB- cord-005453-4057qib7 8956 9 was be VBD cord-005453-4057qib7 8956 10 significantly significantly RB cord-005453-4057qib7 8956 11 associated associate VBN cord-005453-4057qib7 8956 12 with with IN cord-005453-4057qib7 8956 13 higher high JJR cord-005453-4057qib7 8956 14 risk risk NN cord-005453-4057qib7 8956 15 of of IN cord-005453-4057qib7 8956 16 infection infection NN cord-005453-4057qib7 8956 17 . . . cord-005453-4057qib7 8957 1 Identification identification NN cord-005453-4057qib7 8957 2 of of IN cord-005453-4057qib7 8957 3 high high JJ cord-005453-4057qib7 8957 4 risk risk NN cord-005453-4057qib7 8957 5 patients patient NNS cord-005453-4057qib7 8957 6 and and CC cord-005453-4057qib7 8957 7 new new JJ cord-005453-4057qib7 8957 8 prophylactic prophylactic JJ cord-005453-4057qib7 8957 9 and and CC cord-005453-4057qib7 8957 10 treatment treatment NN cord-005453-4057qib7 8957 11 strategies strategy NNS cord-005453-4057qib7 8957 12 may may MD cord-005453-4057qib7 8957 13 improve improve VB cord-005453-4057qib7 8957 14 these these DT cord-005453-4057qib7 8957 15 results result NNS cord-005453-4057qib7 8957 16 . . . cord-005453-4057qib7 8958 1 Disclosure disclosure NN cord-005453-4057qib7 8958 2 : : : cord-005453-4057qib7 8958 3 Nothing nothing NN cord-005453-4057qib7 8958 4 to to TO cord-005453-4057qib7 8958 5 declare declare VB cord-005453-4057qib7 8958 6 . . . cord-005453-4057qib7 8959 1 Methods method NNS cord-005453-4057qib7 8959 2 : : : cord-005453-4057qib7 8959 3 Consecutive consecutive JJ cord-005453-4057qib7 8959 4 patients patient NNS cord-005453-4057qib7 8959 5 admitted admit VBN cord-005453-4057qib7 8959 6 at at IN cord-005453-4057qib7 8959 7 the the DT cord-005453-4057qib7 8959 8 SCT SCT NNP cord-005453-4057qib7 8959 9 unit unit NN cord-005453-4057qib7 8959 10 between between IN cord-005453-4057qib7 8959 11 January-18 January-18 NNP cord-005453-4057qib7 8959 12 to to IN cord-005453-4057qib7 8959 13 November-18 November-18 NNP cord-005453-4057qib7 8959 14 were be VBD cord-005453-4057qib7 8959 15 reviewed review VBN cord-005453-4057qib7 8959 16 . . . cord-005453-4057qib7 8960 1 Only only RB cord-005453-4057qib7 8960 2 first first JJ cord-005453-4057qib7 8960 3 admission admission NN cord-005453-4057qib7 8960 4 was be VBD cord-005453-4057qib7 8960 5 analysed analyse VBN cord-005453-4057qib7 8960 6 . . . cord-005453-4057qib7 8961 1 Screening screening NN cord-005453-4057qib7 8961 2 consisted consist VBD cord-005453-4057qib7 8961 3 of of IN cord-005453-4057qib7 8961 4 rectal rectal JJ cord-005453-4057qib7 8961 5 and and CC cord-005453-4057qib7 8961 6 perineal perineal NN cord-005453-4057qib7 8961 7 swap swap NN cord-005453-4057qib7 8961 8 on on IN cord-005453-4057qib7 8961 9 admission admission NN cord-005453-4057qib7 8961 10 and and CC cord-005453-4057qib7 8961 11 weekly weekly NN cord-005453-4057qib7 8961 12 until until IN cord-005453-4057qib7 8961 13 discharge discharge NN cord-005453-4057qib7 8961 14 . . . cord-005453-4057qib7 8962 1 In in IN cord-005453-4057qib7 8962 2 case case NN cord-005453-4057qib7 8962 3 of of IN cord-005453-4057qib7 8962 4 detection detection NN cord-005453-4057qib7 8962 5 of of IN cord-005453-4057qib7 8962 6 MDRO MDRO NNP cord-005453-4057qib7 8962 7 , , , cord-005453-4057qib7 8962 8 patients patient NNS cord-005453-4057qib7 8962 9 were be VBD cord-005453-4057qib7 8962 10 isolated isolate VBN cord-005453-4057qib7 8962 11 and and CC cord-005453-4057qib7 8962 12 infection infection NN cord-005453-4057qib7 8962 13 control control NN cord-005453-4057qib7 8962 14 strategies strategy NNS cord-005453-4057qib7 8962 15 were be VBD cord-005453-4057qib7 8962 16 applied apply VBN cord-005453-4057qib7 8962 17 . . . cord-005453-4057qib7 8963 1 Results result NNS cord-005453-4057qib7 8963 2 : : : cord-005453-4057qib7 8964 1 67 67 CD cord-005453-4057qib7 8964 2 patients patient NNS cord-005453-4057qib7 8964 3 were be VBD cord-005453-4057qib7 8964 4 analysed analyse VBN cord-005453-4057qib7 8964 5 , , , cord-005453-4057qib7 8964 6 median median JJ cord-005453-4057qib7 8964 7 age age NN cord-005453-4057qib7 8964 8 53 53 CD cord-005453-4057qib7 8964 9 years year NNS cord-005453-4057qib7 8964 10 ( ( -LRB- cord-005453-4057qib7 8964 11 18 18 CD cord-005453-4057qib7 8964 12 - - SYM cord-005453-4057qib7 8964 13 70 70 CD cord-005453-4057qib7 8964 14 ) ) -RRB- cord-005453-4057qib7 8964 15 . . . cord-005453-4057qib7 8965 1 65 65 CD cord-005453-4057qib7 8965 2 % % NN cord-005453-4057qib7 8965 3 were be VBD cord-005453-4057qib7 8965 4 male male JJ cord-005453-4057qib7 8965 5 ( ( -LRB- cord-005453-4057qib7 8965 6 n=44 n=44 NNP cord-005453-4057qib7 8965 7 ) ) -RRB- cord-005453-4057qib7 8965 8 . . . cord-005453-4057qib7 8966 1 Median median JJ cord-005453-4057qib7 8966 2 duration duration NN cord-005453-4057qib7 8966 3 of of IN cord-005453-4057qib7 8966 4 hospitalization hospitalization NN cord-005453-4057qib7 8966 5 was be VBD cord-005453-4057qib7 8966 6 30 30 CD cord-005453-4057qib7 8966 7 days(16 days(16 NNP cord-005453-4057qib7 8966 8 - - HYPH cord-005453-4057qib7 8966 9 133 133 CD cord-005453-4057qib7 8966 10 ) ) -RRB- cord-005453-4057qib7 8966 11 . . . cord-005453-4057qib7 8967 1 293 293 CD cord-005453-4057qib7 8967 2 swabs swab NNS cord-005453-4057qib7 8967 3 were be VBD cord-005453-4057qib7 8967 4 performed perform VBN cord-005453-4057qib7 8967 5 , , , cord-005453-4057qib7 8967 6 with with IN cord-005453-4057qib7 8967 7 a a DT cord-005453-4057qib7 8967 8 median median NN cord-005453-4057qib7 8967 9 of of IN cord-005453-4057qib7 8967 10 4 4 CD cord-005453-4057qib7 8967 11 swaps swap NNS cord-005453-4057qib7 8967 12 / / SYM cord-005453-4057qib7 8967 13 patient patient NN cord-005453-4057qib7 8967 14 ( ( -LRB- cord-005453-4057qib7 8967 15 1 1 CD cord-005453-4057qib7 8967 16 ) ) -RRB- cord-005453-4057qib7 8967 17 ( ( -LRB- cord-005453-4057qib7 8967 18 2 2 LS cord-005453-4057qib7 8967 19 ) ) -RRB- cord-005453-4057qib7 8967 20 ( ( -LRB- cord-005453-4057qib7 8967 21 3 3 LS cord-005453-4057qib7 8967 22 ) ) -RRB- cord-005453-4057qib7 8967 23 ( ( -LRB- cord-005453-4057qib7 8967 24 4 4 LS cord-005453-4057qib7 8967 25 ) ) -RRB- cord-005453-4057qib7 8967 26 ( ( -LRB- cord-005453-4057qib7 8967 27 5 5 LS cord-005453-4057qib7 8967 28 ) ) -RRB- cord-005453-4057qib7 8967 29 ( ( -LRB- cord-005453-4057qib7 8967 30 6 6 LS cord-005453-4057qib7 8967 31 ) ) -RRB- cord-005453-4057qib7 8967 32 ( ( -LRB- cord-005453-4057qib7 8967 33 7 7 CD cord-005453-4057qib7 8967 34 ) ) -RRB- cord-005453-4057qib7 8968 1 ( ( -LRB- cord-005453-4057qib7 8968 2 8) 8) NNP cord-005453-4057qib7 8968 3 ( ( -LRB- cord-005453-4057qib7 8968 4 9 9 CD cord-005453-4057qib7 8968 5 ) ) -RRB- cord-005453-4057qib7 8968 6 ( ( -LRB- cord-005453-4057qib7 8968 7 10 10 CD cord-005453-4057qib7 8968 8 ) ) -RRB- cord-005453-4057qib7 8968 9 ( ( -LRB- cord-005453-4057qib7 8968 10 11 11 CD cord-005453-4057qib7 8968 11 ) ) -RRB- cord-005453-4057qib7 8968 12 ( ( -LRB- cord-005453-4057qib7 8968 13 12 12 CD cord-005453-4057qib7 8968 14 ) ) -RRB- cord-005453-4057qib7 8968 15 ( ( -LRB- cord-005453-4057qib7 8968 16 13 13 CD cord-005453-4057qib7 8968 17 ) ) -RRB- cord-005453-4057qib7 8968 18 ( ( -LRB- cord-005453-4057qib7 8968 19 14 14 CD cord-005453-4057qib7 8968 20 ) ) -RRB- cord-005453-4057qib7 8968 21 ( ( -LRB- cord-005453-4057qib7 8968 22 15 15 CD cord-005453-4057qib7 8968 23 ) ) -RRB- cord-005453-4057qib7 8968 24 ( ( -LRB- cord-005453-4057qib7 8968 25 16 16 CD cord-005453-4057qib7 8968 26 ) ) -RRB- cord-005453-4057qib7 8968 27 ( ( -LRB- cord-005453-4057qib7 8968 28 17 17 CD cord-005453-4057qib7 8968 29 ) ) -RRB- cord-005453-4057qib7 8968 30 . . . cord-005453-4057qib7 8969 1 Patient patient JJ cord-005453-4057qib7 8969 2 characteristics characteristic NNS cord-005453-4057qib7 8969 3 are be VBP cord-005453-4057qib7 8969 4 shown show VBN cord-005453-4057qib7 8969 5 in in IN cord-005453-4057qib7 8969 6 Table Table NNP cord-005453-4057qib7 8969 7 1 1 CD cord-005453-4057qib7 8969 8 . . . cord-005453-4057qib7 8970 1 60 60 CD cord-005453-4057qib7 8970 2 patients patient NNS cord-005453-4057qib7 8970 3 ( ( -LRB- cord-005453-4057qib7 8970 4 90 90 CD cord-005453-4057qib7 8970 5 % % NN cord-005453-4057qib7 8970 6 ) ) -RRB- cord-005453-4057qib7 8970 7 spiked spiked JJ cord-005453-4057qib7 8970 8 fever fever NN cord-005453-4057qib7 8970 9 in in IN cord-005453-4057qib7 8970 10 a a DT cord-005453-4057qib7 8970 11 median median NN cord-005453-4057qib7 8970 12 of of IN cord-005453-4057qib7 8970 13 9 9 CD cord-005453-4057qib7 8970 14 days day NNS cord-005453-4057qib7 8970 15 after after IN cord-005453-4057qib7 8970 16 admission admission NN cord-005453-4057qib7 8970 17 . . . cord-005453-4057qib7 8971 1 13 13 CD cord-005453-4057qib7 8971 2 % % NN cord-005453-4057qib7 8971 3 ( ( -LRB- cord-005453-4057qib7 8971 4 n=9 n=9 NN cord-005453-4057qib7 8971 5 ) ) -RRB- cord-005453-4057qib7 8971 6 had have VBD cord-005453-4057qib7 8971 7 previous previous JJ cord-005453-4057qib7 8971 8 documented document VBN cord-005453-4057qib7 8971 9 MDRO MDRO NNP cord-005453-4057qib7 8971 10 colonization colonization NN cord-005453-4057qib7 8971 11 . . . cord-005453-4057qib7 8972 1 Median median JJ cord-005453-4057qib7 8972 2 neutrophil neutrophil NN cord-005453-4057qib7 8972 3 engraftment engraftment NN cord-005453-4057qib7 8972 4 was be VBD cord-005453-4057qib7 8972 5 15 15 CD cord-005453-4057qib7 8972 6 days day NNS cord-005453-4057qib7 8972 7 ( ( -LRB- cord-005453-4057qib7 8972 8 95%CI 95%ci CD cord-005453-4057qib7 8972 9 14 14 CD cord-005453-4057qib7 8972 10 - - SYM cord-005453-4057qib7 8972 11 15 15 CD cord-005453-4057qib7 8972 12 ) ) -RRB- cord-005453-4057qib7 8972 13 , , . cord-005453-4057qib7 8973 1 In in IN cord-005453-4057qib7 8973 2 24 24 CD cord-005453-4057qib7 8973 3 % % NN cord-005453-4057qib7 8973 4 patients patient NNS cord-005453-4057qib7 8973 5 ( ( -LRB- cord-005453-4057qib7 8973 6 n=16 n=16 NNP cord-005453-4057qib7 8973 7 ) ) -RRB- cord-005453-4057qib7 8973 8 of of IN cord-005453-4057qib7 8973 9 patients patient NNS cord-005453-4057qib7 8973 10 had have VBD cord-005453-4057qib7 8973 11 a a DT cord-005453-4057qib7 8973 12 positive positive JJ cord-005453-4057qib7 8973 13 screen screen NN cord-005453-4057qib7 8973 14 : : : cord-005453-4057qib7 8973 15 in in IN cord-005453-4057qib7 8973 16 8 8 CD cord-005453-4057qib7 8973 17 ( ( -LRB- cord-005453-4057qib7 8973 18 50 50 CD cord-005453-4057qib7 8973 19 % % NN cord-005453-4057qib7 8973 20 ) ) -RRB- cord-005453-4057qib7 8973 21 patients patient NNS cord-005453-4057qib7 8973 22 at at IN cord-005453-4057qib7 8973 23 baseline baseline NN cord-005453-4057qib7 8973 24 and and CC cord-005453-4057qib7 8973 25 in in IN cord-005453-4057qib7 8973 26 8 8 CD cord-005453-4057qib7 8973 27 ( ( -LRB- cord-005453-4057qib7 8973 28 50 50 CD cord-005453-4057qib7 8973 29 % % NN cord-005453-4057qib7 8973 30 ) ) -RRB- cord-005453-4057qib7 8973 31 patients patient NNS cord-005453-4057qib7 8973 32 were be VBD cord-005453-4057qib7 8973 33 detected detect VBN cord-005453-4057qib7 8973 34 for for IN cord-005453-4057qib7 8973 35 the the DT cord-005453-4057qib7 8973 36 first first JJ cord-005453-4057qib7 8973 37 time time NN cord-005453-4057qib7 8973 38 beyond beyond IN cord-005453-4057qib7 8973 39 baseline baseline JJ cord-005453-4057qib7 8973 40 screen screen NN cord-005453-4057qib7 8973 41 . . . cord-005453-4057qib7 8974 1 Cumulative cumulative JJ cord-005453-4057qib7 8974 2 incidence incidence NN cord-005453-4057qib7 8974 3 of of IN cord-005453-4057qib7 8974 4 colonization colonization NN cord-005453-4057qib7 8974 5 at at IN cord-005453-4057qib7 8974 6 7 7 CD cord-005453-4057qib7 8974 7 days day NNS cord-005453-4057qib7 8974 8 was be VBD cord-005453-4057qib7 8974 9 10.4 10.4 CD cord-005453-4057qib7 8974 10 % % NN cord-005453-4057qib7 8974 11 ( ( -LRB- cord-005453-4057qib7 8974 12 95%CI 95%ci CD cord-005453-4057qib7 8974 13 3.2 3.2 CD cord-005453-4057qib7 8974 14 - - HYPH cord-005453-4057qib7 8974 15 17.6 17.6 CD cord-005453-4057qib7 8974 16 ) ) -RRB- cord-005453-4057qib7 8974 17 , , , cord-005453-4057qib7 8974 18 at at IN cord-005453-4057qib7 8974 19 15 15 CD cord-005453-4057qib7 8974 20 days day NNS cord-005453-4057qib7 8974 21 18 18 CD cord-005453-4057qib7 8974 22 % % NN cord-005453-4057qib7 8974 23 ( ( -LRB- cord-005453-4057qib7 8974 24 95%CI 95%ci CD cord-005453-4057qib7 8974 25 8.2 8.2 CD cord-005453-4057qib7 8974 26 - - HYPH cord-005453-4057qib7 8974 27 27.8 27.8 CD cord-005453-4057qib7 8974 28 ) ) -RRB- cord-005453-4057qib7 8974 29 , , , cord-005453-4057qib7 8974 30 and and CC cord-005453-4057qib7 8974 31 at at IN cord-005453-4057qib7 8974 32 30 30 CD cord-005453-4057qib7 8974 33 days day NNS cord-005453-4057qib7 8974 34 19.5 19.5 CD cord-005453-4057qib7 8974 35 % % NN cord-005453-4057qib7 8974 36 ( ( -LRB- cord-005453-4057qib7 8974 37 9.9 9.9 CD cord-005453-4057qib7 8974 38 - - SYM cord-005453-4057qib7 8974 39 29.1 29.1 CD cord-005453-4057qib7 8974 40 % % NN cord-005453-4057qib7 8974 41 ) ) -RRB- cord-005453-4057qib7 8974 42 ( ( -LRB- cord-005453-4057qib7 8974 43 Figure figure NN cord-005453-4057qib7 8974 44 1 1 CD cord-005453-4057qib7 8974 45 ) ) -RRB- cord-005453-4057qib7 8974 46 . . . cord-005453-4057qib7 8975 1 MDRO MDRO NNP cord-005453-4057qib7 8975 2 identified identify VBD cord-005453-4057qib7 8975 3 were be VBD cord-005453-4057qib7 8975 4 : : : cord-005453-4057qib7 8975 5 8 8 CD cord-005453-4057qib7 8975 6 with with IN cord-005453-4057qib7 8975 7 extended extend VBN cord-005453-4057qib7 8975 8 - - HYPH cord-005453-4057qib7 8975 9 spectrum spectrum NN cord-005453-4057qib7 8975 10 beta beta NN cord-005453-4057qib7 8975 11 - - HYPH cord-005453-4057qib7 8975 12 lactamases lactamase NNS cord-005453-4057qib7 8975 13 producing produce VBG cord-005453-4057qib7 8975 14 E. E. NNP cord-005453-4057qib7 8975 15 Coli Coli NNP cord-005453-4057qib7 8975 16 ( ( -LRB- cord-005453-4057qib7 8975 17 ESBL ESBL NNP cord-005453-4057qib7 8975 18 - - HYPH cord-005453-4057qib7 8975 19 EC EC NNP cord-005453-4057qib7 8975 20 ) ) -RRB- cord-005453-4057qib7 8975 21 , , , cord-005453-4057qib7 8975 22 4 4 CD cord-005453-4057qib7 8975 23 multidrug multidrug NN cord-005453-4057qib7 8975 24 - - HYPH cord-005453-4057qib7 8975 25 resistant resistant JJ cord-005453-4057qib7 8975 26 Pseudomonas Pseudomonas NNP cord-005453-4057qib7 8975 27 aeruginosa aeruginosa NN cord-005453-4057qib7 8975 28 ( ( -LRB- cord-005453-4057qib7 8975 29 MR MR NNP cord-005453-4057qib7 8975 30 - - HYPH cord-005453-4057qib7 8975 31 PS PS NNP cord-005453-4057qib7 8975 32 ) ) -RRB- cord-005453-4057qib7 8975 33 , , , cord-005453-4057qib7 8975 34 3 3 CD cord-005453-4057qib7 8975 35 vancomycin vancomycin NN cord-005453-4057qib7 8975 36 resistant resistant JJ cord-005453-4057qib7 8975 37 Enterococci Enterococci NNP cord-005453-4057qib7 8975 38 ( ( -LRB- cord-005453-4057qib7 8975 39 VRE VRE NNP cord-005453-4057qib7 8975 40 ) ) -RRB- cord-005453-4057qib7 8975 41 and and CC cord-005453-4057qib7 8975 42 1 1 CD cord-005453-4057qib7 8975 43 patient patient NN cord-005453-4057qib7 8975 44 with with IN cord-005453-4057qib7 8976 1 carbapenemaseproducing carbapenemaseproduce VBG cord-005453-4057qib7 8976 2 ( ( -LRB- cord-005453-4057qib7 8976 3 CP CP NNP cord-005453-4057qib7 8976 4 ) ) -RRB- cord-005453-4057qib7 8976 5 Citrobacter Citrobacter NNP cord-005453-4057qib7 8976 6 freundii freundii NNP cord-005453-4057qib7 8976 7 . . . cord-005453-4057qib7 8977 1 7/16 7/16 CD cord-005453-4057qib7 8977 2 colonized colonize VBN cord-005453-4057qib7 8977 3 patients patient NNS cord-005453-4057qib7 8977 4 developed develop VBD cord-005453-4057qib7 8977 5 MDRO MDRO NNP cord-005453-4057qib7 8977 6 infection infection NN cord-005453-4057qib7 8977 7 ( ( -LRB- cord-005453-4057qib7 8977 8 44 44 CD cord-005453-4057qib7 8977 9 % % NN cord-005453-4057qib7 8977 10 ) ) -RRB- cord-005453-4057qib7 8978 1 : : : cord-005453-4057qib7 8978 2 4 4 CD cord-005453-4057qib7 8978 3 patients patient NNS cord-005453-4057qib7 8978 4 MR MR NNP cord-005453-4057qib7 8978 5 - - HYPH cord-005453-4057qib7 8978 6 PS PS NNP cord-005453-4057qib7 8978 7 , , , cord-005453-4057qib7 8978 8 site site NN cord-005453-4057qib7 8978 9 of of IN cord-005453-4057qib7 8978 10 infection infection NN cord-005453-4057qib7 8978 11 was be VBD cord-005453-4057qib7 8978 12 2 2 CD cord-005453-4057qib7 8978 13 urinary urinary JJ cord-005453-4057qib7 8978 14 tract tract NN cord-005453-4057qib7 8978 15 infection infection NN cord-005453-4057qib7 8978 16 ( ( -LRB- cord-005453-4057qib7 8978 17 UTI UTI NNP cord-005453-4057qib7 8978 18 ) ) -RRB- cord-005453-4057qib7 8978 19 , , , cord-005453-4057qib7 8978 20 1 1 CD cord-005453-4057qib7 8978 21 urethritis urethritis NN cord-005453-4057qib7 8978 22 , , , cord-005453-4057qib7 8978 23 1 1 CD cord-005453-4057qib7 8978 24 genital genital JJ cord-005453-4057qib7 8978 25 ulcer ulcer NN cord-005453-4057qib7 8978 26 . . . cord-005453-4057qib7 8979 1 Two two CD cord-005453-4057qib7 8979 2 patients patient NNS cord-005453-4057qib7 8979 3 were be VBD cord-005453-4057qib7 8979 4 treated treat VBN cord-005453-4057qib7 8979 5 with with IN cord-005453-4057qib7 8979 6 ceftolozane/ ceftolozane/ CD cord-005453-4057qib7 8979 7 tazobactam tazobactam NNS cord-005453-4057qib7 8979 8 , , , cord-005453-4057qib7 8979 9 1 1 CD cord-005453-4057qib7 8979 10 with with IN cord-005453-4057qib7 8979 11 meropenem+amikacin;2 meropenem+amikacin;2 NNP cord-005453-4057qib7 8979 12 patients patient NNS cord-005453-4057qib7 8979 13 ESBL ESBL NNP cord-005453-4057qib7 8979 14 - - HYPH cord-005453-4057qib7 8979 15 EC EC NNP cord-005453-4057qib7 8979 16 both both CC cord-005453-4057qib7 8979 17 UTI UTI NNP cord-005453-4057qib7 8979 18 treated treat VBD cord-005453-4057qib7 8979 19 with with IN cord-005453-4057qib7 8979 20 meropenem meropenem NNP cord-005453-4057qib7 8979 21 ; ; : cord-005453-4057qib7 8979 22 1 1 CD cord-005453-4057qib7 8979 23 patient patient NN cord-005453-4057qib7 8979 24 CPcitrobacter CPcitrobacter NNP cord-005453-4057qib7 8979 25 freundii freundii JJ cord-005453-4057qib7 8979 26 UTI UTI NNP cord-005453-4057qib7 8979 27 treated treat VBN cord-005453-4057qib7 8979 28 with with IN cord-005453-4057qib7 8979 29 ceftazidime ceftazidime NNP cord-005453-4057qib7 8979 30 / / SYM cord-005453-4057qib7 8979 31 avibactam avibactam NNS cord-005453-4057qib7 8979 32 . . . cord-005453-4057qib7 8980 1 In in IN cord-005453-4057qib7 8980 2 75 75 CD cord-005453-4057qib7 8980 3 % % NN cord-005453-4057qib7 8980 4 patients patient NNS cord-005453-4057qib7 8980 5 ( ( -LRB- cord-005453-4057qib7 8980 6 12/16 12/16 CD cord-005453-4057qib7 8980 7 ) ) -RRB- cord-005453-4057qib7 8980 8 antibiotic antibiotic JJ cord-005453-4057qib7 8980 9 treatment treatment NN cord-005453-4057qib7 8980 10 at at IN cord-005453-4057qib7 8980 11 febrile febrile JJ cord-005453-4057qib7 8980 12 episode episode NN cord-005453-4057qib7 8980 13 was be VBD cord-005453-4057qib7 8980 14 guided guide VBN cord-005453-4057qib7 8980 15 by by IN cord-005453-4057qib7 8980 16 positive positive JJ cord-005453-4057qib7 8980 17 screening screening NN cord-005453-4057qib7 8980 18 . . . cord-005453-4057qib7 8981 1 No no DT cord-005453-4057qib7 8981 2 MDRO MDRO NNP cord-005453-4057qib7 8981 3 related relate VBD cord-005453-4057qib7 8981 4 ICU ICU NNP cord-005453-4057qib7 8981 5 admission admission NN cord-005453-4057qib7 8981 6 or or CC cord-005453-4057qib7 8981 7 mortality mortality NN cord-005453-4057qib7 8981 8 was be VBD cord-005453-4057qib7 8981 9 observed observe VBN cord-005453-4057qib7 8981 10 . . . cord-005453-4057qib7 8982 1 In in IN cord-005453-4057qib7 8982 2 76 76 CD cord-005453-4057qib7 8982 3 % % NN cord-005453-4057qib7 8982 4 patients patient NNS cord-005453-4057qib7 8982 5 ( ( -LRB- cord-005453-4057qib7 8982 6 n=51 n=51 NNP cord-005453-4057qib7 8982 7 ) ) -RRB- cord-005453-4057qib7 8982 8 Background background NN cord-005453-4057qib7 8982 9 : : : cord-005453-4057qib7 8982 10 Hepatitis hepatitis NN cord-005453-4057qib7 8982 11 E e NN cord-005453-4057qib7 8982 12 virus virus NN cord-005453-4057qib7 8982 13 ( ( -LRB- cord-005453-4057qib7 8982 14 HEV hev NN cord-005453-4057qib7 8982 15 ) ) -RRB- cord-005453-4057qib7 8982 16 can can MD cord-005453-4057qib7 8982 17 cause cause VB cord-005453-4057qib7 8982 18 chronic chronic JJ cord-005453-4057qib7 8982 19 infection infection NN cord-005453-4057qib7 8982 20 and and CC cord-005453-4057qib7 8982 21 liver liver NN cord-005453-4057qib7 8982 22 cirrhosis cirrhosis NN cord-005453-4057qib7 8982 23 in in IN cord-005453-4057qib7 8982 24 immunocompromised immunocompromised JJ cord-005453-4057qib7 8982 25 individuals individual NNS cord-005453-4057qib7 8982 26 . . . cord-005453-4057qib7 8983 1 There there EX cord-005453-4057qib7 8983 2 is be VBZ cord-005453-4057qib7 8983 3 limited limited JJ cord-005453-4057qib7 8983 4 data datum NNS cord-005453-4057qib7 8983 5 on on IN cord-005453-4057qib7 8983 6 HEV HEV NNP cord-005453-4057qib7 8983 7 infections infection NNS cord-005453-4057qib7 8983 8 in in IN cord-005453-4057qib7 8983 9 patients patient NNS cord-005453-4057qib7 8983 10 undergoing undergo VBG cord-005453-4057qib7 8983 11 allogeneic allogeneic IN cord-005453-4057qib7 8983 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 8983 13 stem stem NN cord-005453-4057qib7 8983 14 cell cell NN cord-005453-4057qib7 8983 15 transplantation transplantation NN cord-005453-4057qib7 8983 16 ( ( -LRB- cord-005453-4057qib7 8983 17 HSCT HSCT NNP cord-005453-4057qib7 8983 18 ) ) -RRB- cord-005453-4057qib7 8983 19 . . . cord-005453-4057qib7 8984 1 The the DT cord-005453-4057qib7 8984 2 aim aim NN cord-005453-4057qib7 8984 3 of of IN cord-005453-4057qib7 8984 4 this this DT cord-005453-4057qib7 8984 5 study study NN cord-005453-4057qib7 8984 6 was be VBD cord-005453-4057qib7 8984 7 to to TO cord-005453-4057qib7 8984 8 investigate investigate VB cord-005453-4057qib7 8984 9 the the DT cord-005453-4057qib7 8984 10 frequency frequency NN cord-005453-4057qib7 8984 11 and and CC cord-005453-4057qib7 8984 12 clinical clinical JJ cord-005453-4057qib7 8984 13 importance importance NN cord-005453-4057qib7 8984 14 of of IN cord-005453-4057qib7 8984 15 HEV HEV NNP cord-005453-4057qib7 8984 16 in in IN cord-005453-4057qib7 8984 17 a a DT cord-005453-4057qib7 8984 18 Swedish swedish JJ cord-005453-4057qib7 8984 19 cohort cohort NN cord-005453-4057qib7 8984 20 of of IN cord-005453-4057qib7 8984 21 HSCT HSCT NNP cord-005453-4057qib7 8984 22 recipients recipient NNS cord-005453-4057qib7 8984 23 . . . cord-005453-4057qib7 8985 1 Methods method NNS cord-005453-4057qib7 8985 2 : : : cord-005453-4057qib7 8985 3 We -PRON- PRP cord-005453-4057qib7 8985 4 analyzed analyze VBD cord-005453-4057qib7 8985 5 serum serum NN cord-005453-4057qib7 8985 6 samples sample NNS cord-005453-4057qib7 8985 7 from from IN cord-005453-4057qib7 8985 8 262 262 CD cord-005453-4057qib7 8985 9 HSCT HSCT NNP cord-005453-4057qib7 8985 10 patients patient NNS cord-005453-4057qib7 8985 11 ( ( -LRB- cord-005453-4057qib7 8985 12 241 241 CD cord-005453-4057qib7 8985 13 adults adult NNS cord-005453-4057qib7 8985 14 and and CC cord-005453-4057qib7 8985 15 21 21 CD cord-005453-4057qib7 8985 16 children child NNS cord-005453-4057qib7 8985 17 ) ) -RRB- cord-005453-4057qib7 8985 18 , , , cord-005453-4057qib7 8985 19 collected collect VBN cord-005453-4057qib7 8985 20 6 6 CD cord-005453-4057qib7 8985 21 months month NNS cord-005453-4057qib7 8985 22 after after IN cord-005453-4057qib7 8985 23 HSCT HSCT NNP cord-005453-4057qib7 8985 24 . . . cord-005453-4057qib7 8986 1 HEV HEV NNP cord-005453-4057qib7 8986 2 IgG IgG NNP cord-005453-4057qib7 8986 3 and and CC cord-005453-4057qib7 8986 4 IgM IgM NNP cord-005453-4057qib7 8986 5 were be VBD cord-005453-4057qib7 8986 6 detected detect VBN cord-005453-4057qib7 8986 7 by by IN cord-005453-4057qib7 8986 8 ELISA ELISA NNP cord-005453-4057qib7 8986 9 ( ( -LRB- cord-005453-4057qib7 8986 10 Dia Dia NNP cord-005453-4057qib7 8986 11 . . . cord-005453-4057qib7 8987 1 Pro Pro NNP cord-005453-4057qib7 8987 2 ® ® NNP cord-005453-4057qib7 8987 3 ) ) -RRB- cord-005453-4057qib7 8987 4 , , , cord-005453-4057qib7 8987 5 HEV HEV NNP cord-005453-4057qib7 8987 6 RNA RNA NNP cord-005453-4057qib7 8987 7 by by IN cord-005453-4057qib7 8987 8 reverse reverse JJ cord-005453-4057qib7 8987 9 transcriptase transcriptase NN cord-005453-4057qib7 8987 10 PCR pcr NN cord-005453-4057qib7 8987 11 , , , cord-005453-4057qib7 8987 12 and and CC cord-005453-4057qib7 8987 13 quantification quantification NN cord-005453-4057qib7 8987 14 of of IN cord-005453-4057qib7 8987 15 HEV HEV NNP cord-005453-4057qib7 8987 16 RNA RNA NNP cord-005453-4057qib7 8987 17 was be VBD cord-005453-4057qib7 8987 18 performed perform VBN cord-005453-4057qib7 8987 19 by by IN cord-005453-4057qib7 8987 20 digital digital JJ cord-005453-4057qib7 8987 21 PCR PCR NNP cord-005453-4057qib7 8987 22 . . . cord-005453-4057qib7 8988 1 In in IN cord-005453-4057qib7 8988 2 all all DT cord-005453-4057qib7 8988 3 patients patient NNS cord-005453-4057qib7 8988 4 , , , cord-005453-4057qib7 8988 5 who who WP cord-005453-4057qib7 8988 6 were be VBD cord-005453-4057qib7 8988 7 positive positive JJ cord-005453-4057qib7 8988 8 for for IN cord-005453-4057qib7 8988 9 HEV HEV NNP cord-005453-4057qib7 8988 10 - - HYPH cord-005453-4057qib7 8988 11 RNA RNA NNP cord-005453-4057qib7 8988 12 and/or and/or CC cord-005453-4057qib7 8988 13 serology serology NN cord-005453-4057qib7 8988 14 at at IN cord-005453-4057qib7 8988 15 6 6 CD cord-005453-4057qib7 8988 16 months month NNS cord-005453-4057qib7 8988 17 , , , cord-005453-4057qib7 8988 18 also also RB cord-005453-4057qib7 8988 19 samples sample NNS cord-005453-4057qib7 8988 20 collected collect VBN cord-005453-4057qib7 8988 21 at at IN cord-005453-4057qib7 8988 22 the the DT cord-005453-4057qib7 8988 23 time time NN cord-005453-4057qib7 8988 24 of of IN cord-005453-4057qib7 8988 25 HSCT HSCT NNP cord-005453-4057qib7 8988 26 from from IN cord-005453-4057qib7 8988 27 both both CC cord-005453-4057qib7 8988 28 the the DT cord-005453-4057qib7 8988 29 patients patient NNS cord-005453-4057qib7 8988 30 and and CC cord-005453-4057qib7 8988 31 their -PRON- PRP$ cord-005453-4057qib7 8988 32 donors donor NNS cord-005453-4057qib7 8988 33 were be VBD cord-005453-4057qib7 8988 34 analyzed analyze VBN cord-005453-4057qib7 8988 35 . . . cord-005453-4057qib7 8989 1 In in IN cord-005453-4057qib7 8989 2 the the DT cord-005453-4057qib7 8989 3 HEV HEV NNP cord-005453-4057qib7 8989 4 RNA RNA NNP cord-005453-4057qib7 8989 5 positive positive JJ cord-005453-4057qib7 8989 6 patients patient NNS cord-005453-4057qib7 8989 7 , , , cord-005453-4057qib7 8989 8 additional additional JJ cord-005453-4057qib7 8989 9 samples sample NNS cord-005453-4057qib7 8989 10 were be VBD cord-005453-4057qib7 8989 11 analyzed analyze VBN cord-005453-4057qib7 8989 12 to to TO cord-005453-4057qib7 8989 13 determine determine VB cord-005453-4057qib7 8989 14 the the DT cord-005453-4057qib7 8989 15 duration duration NN cord-005453-4057qib7 8989 16 of of IN cord-005453-4057qib7 8989 17 viremia viremia NN cord-005453-4057qib7 8989 18 . . . cord-005453-4057qib7 8990 1 Three three CD cord-005453-4057qib7 8990 2 HEV HEV NNP cord-005453-4057qib7 8990 3 RNA RNA NNP cord-005453-4057qib7 8990 4 negative negative JJ cord-005453-4057qib7 8990 5 controls control NNS cord-005453-4057qib7 8990 6 were be VBD cord-005453-4057qib7 8990 7 selected select VBN cord-005453-4057qib7 8990 8 for for IN cord-005453-4057qib7 8990 9 each each DT cord-005453-4057qib7 8990 10 case case NN cord-005453-4057qib7 8990 11 of of IN cord-005453-4057qib7 8990 12 HEV HEV NNP cord-005453-4057qib7 8990 13 infection infection NN cord-005453-4057qib7 8990 14 , , , cord-005453-4057qib7 8990 15 matched match VBN cord-005453-4057qib7 8990 16 for for IN cord-005453-4057qib7 8990 17 age age NN cord-005453-4057qib7 8990 18 , , , cord-005453-4057qib7 8990 19 diagnosis diagnosis NN cord-005453-4057qib7 8990 20 , , , cord-005453-4057qib7 8990 21 conditioning conditioning NN cord-005453-4057qib7 8990 22 regimen regimen NN cord-005453-4057qib7 8990 23 and and CC cord-005453-4057qib7 8990 24 donor donor NN cord-005453-4057qib7 8990 25 type type NN cord-005453-4057qib7 8990 26 . . . cord-005453-4057qib7 8991 1 Results result NNS cord-005453-4057qib7 8991 2 : : : cord-005453-4057qib7 8992 1 HEV HEV NNP cord-005453-4057qib7 8992 2 RNA RNA NNP cord-005453-4057qib7 8992 3 was be VBD cord-005453-4057qib7 8992 4 detected detect VBN cord-005453-4057qib7 8992 5 in in IN cord-005453-4057qib7 8992 6 8/262 8/262 CD cord-005453-4057qib7 8992 7 ( ( -LRB- cord-005453-4057qib7 8992 8 3.1 3.1 CD cord-005453-4057qib7 8992 9 % % NN cord-005453-4057qib7 8992 10 ) ) -RRB- cord-005453-4057qib7 8992 11 patients patient NNS cord-005453-4057qib7 8992 12 . . . cord-005453-4057qib7 8993 1 In in IN cord-005453-4057qib7 8993 2 three three CD cord-005453-4057qib7 8993 3 of of IN cord-005453-4057qib7 8993 4 the the DT cord-005453-4057qib7 8993 5 patients patient NNS cord-005453-4057qib7 8993 6 HEV HEV NNP cord-005453-4057qib7 8993 7 RNA RNA NNP cord-005453-4057qib7 8993 8 was be VBD cord-005453-4057qib7 8993 9 positive positive JJ cord-005453-4057qib7 8993 10 during during IN cord-005453-4057qib7 8993 11 a a DT cord-005453-4057qib7 8993 12 period period NN cord-005453-4057qib7 8993 13 of of IN cord-005453-4057qib7 8993 14 3 3 CD cord-005453-4057qib7 8993 15 - - SYM cord-005453-4057qib7 8993 16 8 8 CD cord-005453-4057qib7 8993 17 months month NNS cord-005453-4057qib7 8993 18 , , , cord-005453-4057qib7 8993 19 and and CC cord-005453-4057qib7 8993 20 two two CD cord-005453-4057qib7 8993 21 of of IN cord-005453-4057qib7 8993 22 these these DT cord-005453-4057qib7 8993 23 patients patient NNS cord-005453-4057qib7 8993 24 were be VBD cord-005453-4057qib7 8993 25 infected infect VBN cord-005453-4057qib7 8993 26 already already RB cord-005453-4057qib7 8993 27 at at IN cord-005453-4057qib7 8993 28 the the DT cord-005453-4057qib7 8993 29 time time NN cord-005453-4057qib7 8993 30 of of IN cord-005453-4057qib7 8993 31 HSCT HSCT NNP cord-005453-4057qib7 8993 32 . . . cord-005453-4057qib7 8994 1 In in IN cord-005453-4057qib7 8994 2 five five CD cord-005453-4057qib7 8994 3 patients patient NNS cord-005453-4057qib7 8994 4 HEV HEV NNP cord-005453-4057qib7 8994 5 - - HYPH cord-005453-4057qib7 8994 6 RNA RNA NNP cord-005453-4057qib7 8994 7 was be VBD cord-005453-4057qib7 8994 8 positive positive JJ cord-005453-4057qib7 8994 9 , , , cord-005453-4057qib7 8994 10 at at IN cord-005453-4057qib7 8994 11 a a DT cord-005453-4057qib7 8994 12 low low JJ cord-005453-4057qib7 8994 13 level level NN cord-005453-4057qib7 8994 14 , , , cord-005453-4057qib7 8994 15 only only RB cord-005453-4057qib7 8994 16 at at IN cord-005453-4057qib7 8994 17 6 6 CD cord-005453-4057qib7 8994 18 months month NNS cord-005453-4057qib7 8994 19 . . . cord-005453-4057qib7 8995 1 11/262 11/262 CD cord-005453-4057qib7 8995 2 ( ( -LRB- cord-005453-4057qib7 8995 3 4.2 4.2 CD cord-005453-4057qib7 8995 4 % % NN cord-005453-4057qib7 8995 5 ) ) -RRB- cord-005453-4057qib7 8996 1 patients patient NNS cord-005453-4057qib7 8996 2 had have VBD cord-005453-4057qib7 8996 3 detectable detectable JJ cord-005453-4057qib7 8996 4 HEV HEV NNP cord-005453-4057qib7 8996 5 IgG igg NN cord-005453-4057qib7 8996 6 and/or and/or CC cord-005453-4057qib7 8996 7 IgM IgM NNP cord-005453-4057qib7 8996 8 , , , cord-005453-4057qib7 8996 9 whereof whereof WP cord-005453-4057qib7 8996 10 eight eight CD cord-005453-4057qib7 8996 11 patients patient NNS cord-005453-4057qib7 8996 12 were be VBD cord-005453-4057qib7 8996 13 HEV HEV NNP cord-005453-4057qib7 8996 14 RNA RNA NNP cord-005453-4057qib7 8996 15 negative negative JJ cord-005453-4057qib7 8996 16 . . . cord-005453-4057qib7 8997 1 In in IN cord-005453-4057qib7 8997 2 4/8 4/8 CD cord-005453-4057qib7 8997 3 ( ( -LRB- cord-005453-4057qib7 8997 4 50 50 CD cord-005453-4057qib7 8997 5 % % NN cord-005453-4057qib7 8997 6 ) ) -RRB- cord-005453-4057qib7 8997 7 patients patient NNS cord-005453-4057qib7 8997 8 with with IN cord-005453-4057qib7 8997 9 HEV HEV NNP cord-005453-4057qib7 8997 10 infection infection NN cord-005453-4057qib7 8998 1 ( ( -LRB- cord-005453-4057qib7 8998 2 HEV HEV NNP cord-005453-4057qib7 8998 3 RNA RNA NNP cord-005453-4057qib7 8998 4 positive positive JJ cord-005453-4057qib7 8998 5 ) ) -RRB- cord-005453-4057qib7 8998 6 alanine alanine JJ cord-005453-4057qib7 8998 7 aminotransferase aminotransferase NN cord-005453-4057qib7 8998 8 ( ( -LRB- cord-005453-4057qib7 8998 9 ALT ALT NNP cord-005453-4057qib7 8998 10 ) ) -RRB- cord-005453-4057qib7 8998 11 was be VBD cord-005453-4057qib7 8998 12 > > NFP cord-005453-4057qib7 8998 13 3 3 CD cord-005453-4057qib7 8998 14 upper upper JJ cord-005453-4057qib7 8998 15 limit limit NN cord-005453-4057qib7 8998 16 of of IN cord-005453-4057qib7 8998 17 normal normal JJ cord-005453-4057qib7 8998 18 ( ( -LRB- cord-005453-4057qib7 8998 19 ULN ULN NNP cord-005453-4057qib7 8998 20 ) ) -RRB- cord-005453-4057qib7 8998 21 , , , cord-005453-4057qib7 8998 22 in in IN cord-005453-4057qib7 8998 23 1/8 1/8 CD cord-005453-4057qib7 8998 24 ( ( -LRB- cord-005453-4057qib7 8998 25 12.5 12.5 CD cord-005453-4057qib7 8998 26 % % NN cord-005453-4057qib7 8998 27 ) ) -RRB- cord-005453-4057qib7 8998 28 patients patient NNS cord-005453-4057qib7 8998 29 > > XX cord-005453-4057qib7 8998 30 1.5 1.5 CD cord-005453-4057qib7 8998 31 ULN ULN NNP cord-005453-4057qib7 8998 32 , , , cord-005453-4057qib7 8998 33 and and CC cord-005453-4057qib7 8998 34 in in IN cord-005453-4057qib7 8998 35 3/8 3/8 CD cord-005453-4057qib7 8998 36 ( ( -LRB- cord-005453-4057qib7 8998 37 37.5 37.5 CD cord-005453-4057qib7 8998 38 % % NN cord-005453-4057qib7 8998 39 ) ) -RRB- cord-005453-4057qib7 8999 1 patients patient NNS cord-005453-4057qib7 8999 2 ALT ALT NNP cord-005453-4057qib7 8999 3 was be VBD cord-005453-4057qib7 8999 4 normal normal JJ cord-005453-4057qib7 8999 5 , , , cord-005453-4057qib7 8999 6 at at IN cord-005453-4057qib7 8999 7 6 6 CD cord-005453-4057qib7 8999 8 months month NNS cord-005453-4057qib7 8999 9 after after IN cord-005453-4057qib7 8999 10 HSCT HSCT NNP cord-005453-4057qib7 8999 11 . . . cord-005453-4057qib7 9000 1 Bilirubin bilirubin NN cord-005453-4057qib7 9000 2 was be VBD cord-005453-4057qib7 9000 3 elevated elevate VBN cord-005453-4057qib7 9000 4 > > XX cord-005453-4057qib7 9000 5 1.5 1.5 CD cord-005453-4057qib7 9000 6 ULN ULN NNP cord-005453-4057qib7 9000 7 in in IN cord-005453-4057qib7 9000 8 1/8 1/8 CD cord-005453-4057qib7 9000 9 ( ( -LRB- cord-005453-4057qib7 9000 10 12.5 12.5 CD cord-005453-4057qib7 9000 11 % % NN cord-005453-4057qib7 9000 12 ) ) -RRB- cord-005453-4057qib7 9000 13 patients patient NNS cord-005453-4057qib7 9000 14 , , , cord-005453-4057qib7 9000 15 and and CC cord-005453-4057qib7 9000 16 > > XX cord-005453-4057qib7 9000 17 3 3 CD cord-005453-4057qib7 9000 18 ULN ULN NNP cord-005453-4057qib7 9000 19 in in IN cord-005453-4057qib7 9000 20 no no DT cord-005453-4057qib7 9000 21 patient patient NN cord-005453-4057qib7 9000 22 at at IN cord-005453-4057qib7 9000 23 6 6 CD cord-005453-4057qib7 9000 24 months month NNS cord-005453-4057qib7 9000 25 after after IN cord-005453-4057qib7 9000 26 HSCT HSCT NNP cord-005453-4057qib7 9000 27 . . . cord-005453-4057qib7 9001 1 Two two CD cord-005453-4057qib7 9001 2 patients patient NNS cord-005453-4057qib7 9001 3 died die VBD cord-005453-4057qib7 9001 4 with with IN cord-005453-4057qib7 9001 5 ongoing ongoing JJ cord-005453-4057qib7 9001 6 signs sign NNS cord-005453-4057qib7 9001 7 of of IN cord-005453-4057qib7 9001 8 hepatitis hepatitis NN cord-005453-4057qib7 9001 9 and and CC cord-005453-4057qib7 9001 10 HEV HEV NNP cord-005453-4057qib7 9001 11 RNA RNA NNP cord-005453-4057qib7 9001 12 detected detect VBD cord-005453-4057qib7 9001 13 in in IN cord-005453-4057qib7 9001 14 blood blood NN cord-005453-4057qib7 9001 15 . . . cord-005453-4057qib7 9002 1 One one CD cord-005453-4057qib7 9002 2 of of IN cord-005453-4057qib7 9002 3 them -PRON- PRP cord-005453-4057qib7 9002 4 developed develop VBD cord-005453-4057qib7 9002 5 acute acute JJ cord-005453-4057qib7 9002 6 liver liver NN cord-005453-4057qib7 9002 7 failure failure NN cord-005453-4057qib7 9002 8 , , , cord-005453-4057qib7 9002 9 at at IN cord-005453-4057qib7 9002 10 the the DT cord-005453-4057qib7 9002 11 time time NN cord-005453-4057qib7 9002 12 interpreted interpret VBN cord-005453-4057qib7 9002 13 as as IN cord-005453-4057qib7 9002 14 drug drug NN cord-005453-4057qib7 9002 15 toxicity toxicity NN cord-005453-4057qib7 9002 16 , , , cord-005453-4057qib7 9002 17 and and CC cord-005453-4057qib7 9002 18 died die VBD cord-005453-4057qib7 9002 19 of of IN cord-005453-4057qib7 9002 20 multi multi JJ cord-005453-4057qib7 9002 21 - - JJ cord-005453-4057qib7 9002 22 organ organ JJ cord-005453-4057qib7 9002 23 failure failure NN cord-005453-4057qib7 9002 24 . . . cord-005453-4057qib7 9003 1 The the DT cord-005453-4057qib7 9003 2 other other JJ cord-005453-4057qib7 9003 3 patient patient NN cord-005453-4057qib7 9003 4 died die VBD cord-005453-4057qib7 9003 5 of of IN cord-005453-4057qib7 9003 6 unrelated unrelated JJ cord-005453-4057qib7 9003 7 causes cause NNS cord-005453-4057qib7 9003 8 . . . cord-005453-4057qib7 9004 1 The the DT cord-005453-4057qib7 9004 2 remaining remain VBG cord-005453-4057qib7 9004 3 six six CD cord-005453-4057qib7 9004 4 patients patient NNS cord-005453-4057qib7 9004 5 had have VBD cord-005453-4057qib7 9004 6 cleared clear VBN cord-005453-4057qib7 9004 7 the the DT cord-005453-4057qib7 9004 8 infection infection NN cord-005453-4057qib7 9004 9 at at IN cord-005453-4057qib7 9004 10 7 7 CD cord-005453-4057qib7 9004 11 - - SYM cord-005453-4057qib7 9004 12 24 24 CD cord-005453-4057qib7 9004 13 ( ( -LRB- cord-005453-4057qib7 9004 14 median median JJ cord-005453-4057qib7 9004 15 8.5 8.5 CD cord-005453-4057qib7 9004 16 ) ) -RRB- cord-005453-4057qib7 9004 17 months month NNS cord-005453-4057qib7 9004 18 after after IN cord-005453-4057qib7 9004 19 HSCT HSCT NNP cord-005453-4057qib7 9004 20 . . . cord-005453-4057qib7 9005 1 Active active JJ cord-005453-4057qib7 9005 2 GVHD GVHD NNP cord-005453-4057qib7 9005 3 was be VBD cord-005453-4057qib7 9005 4 present present JJ cord-005453-4057qib7 9005 5 at at IN cord-005453-4057qib7 9005 6 6 6 CD cord-005453-4057qib7 9005 7 months month NNS cord-005453-4057qib7 9005 8 after after IN cord-005453-4057qib7 9005 9 HSCT HSCT NNP cord-005453-4057qib7 9005 10 in in IN cord-005453-4057qib7 9005 11 5/8 5/8 CD cord-005453-4057qib7 9005 12 ( ( -LRB- cord-005453-4057qib7 9005 13 62.5 62.5 CD cord-005453-4057qib7 9005 14 % % NN cord-005453-4057qib7 9005 15 ) ) -RRB- cord-005453-4057qib7 9005 16 patients patient NNS cord-005453-4057qib7 9005 17 with with IN cord-005453-4057qib7 9005 18 HEV HEV NNP cord-005453-4057qib7 9005 19 infection infection NN cord-005453-4057qib7 9005 20 , , , cord-005453-4057qib7 9005 21 involving involve VBG cord-005453-4057qib7 9005 22 the the DT cord-005453-4057qib7 9005 23 liver liver NN cord-005453-4057qib7 9005 24 in in IN cord-005453-4057qib7 9005 25 3 3 CD cord-005453-4057qib7 9005 26 of of IN cord-005453-4057qib7 9005 27 these these DT cord-005453-4057qib7 9005 28 patients patient NNS cord-005453-4057qib7 9005 29 . . . cord-005453-4057qib7 9006 1 Corticosteroid corticosteroid JJ cord-005453-4057qib7 9006 2 treatment treatment NN cord-005453-4057qib7 9006 3 was be VBD cord-005453-4057qib7 9006 4 ongoing ongoing JJ cord-005453-4057qib7 9006 5 in in IN cord-005453-4057qib7 9006 6 6/8 6/8 CD cord-005453-4057qib7 9006 7 ( ( -LRB- cord-005453-4057qib7 9006 8 75 75 CD cord-005453-4057qib7 9006 9 % % NN cord-005453-4057qib7 9006 10 ) ) -RRB- cord-005453-4057qib7 9006 11 patients patient NNS cord-005453-4057qib7 9006 12 ; ; : cord-005453-4057qib7 9006 13 the the DT cord-005453-4057qib7 9006 14 mean mean JJ cord-005453-4057qib7 9006 15 dose dose NN cord-005453-4057qib7 9006 16 during during IN cord-005453-4057qib7 9006 17 the the DT cord-005453-4057qib7 9006 18 14 14 CD cord-005453-4057qib7 9006 19 preceding precede VBG cord-005453-4057qib7 9006 20 days day NNS cord-005453-4057qib7 9006 21 was be VBD cord-005453-4057qib7 9006 22 > > NFP cord-005453-4057qib7 9006 23 0.5 0.5 CD cord-005453-4057qib7 9006 24 mg mg NNP cord-005453-4057qib7 9006 25 / / SYM cord-005453-4057qib7 9006 26 kg kg NNP cord-005453-4057qib7 9006 27 in in IN cord-005453-4057qib7 9006 28 1/8 1/8 CD cord-005453-4057qib7 9006 29 ( ( -LRB- cord-005453-4057qib7 9006 30 12.5 12.5 CD cord-005453-4057qib7 9006 31 % % NN cord-005453-4057qib7 9006 32 ) ) -RRB- cord-005453-4057qib7 9006 33 patient patient NN cord-005453-4057qib7 9006 34 , , , cord-005453-4057qib7 9006 35 0.25 0.25 CD cord-005453-4057qib7 9006 36 - - SYM cord-005453-4057qib7 9006 37 0.5 0.5 CD cord-005453-4057qib7 9006 38 mg/ mg/ NN cord-005453-4057qib7 9006 39 kg kg NNP cord-005453-4057qib7 9006 40 in in IN cord-005453-4057qib7 9006 41 3/8 3/8 CD cord-005453-4057qib7 9006 42 ( ( -LRB- cord-005453-4057qib7 9006 43 37.5 37.5 CD cord-005453-4057qib7 9006 44 % % NN cord-005453-4057qib7 9006 45 ) ) -RRB- cord-005453-4057qib7 9006 46 patients patient NNS cord-005453-4057qib7 9006 47 , , , cord-005453-4057qib7 9006 48 and and CC cord-005453-4057qib7 9006 49 < < XX cord-005453-4057qib7 9006 50 0.25 0.25 CD cord-005453-4057qib7 9006 51 mg mg NNP cord-005453-4057qib7 9006 52 / / SYM cord-005453-4057qib7 9006 53 kg kg NNS cord-005453-4057qib7 9006 54 in in IN cord-005453-4057qib7 9006 55 4/8 4/8 CD cord-005453-4057qib7 9006 56 ( ( -LRB- cord-005453-4057qib7 9006 57 50 50 CD cord-005453-4057qib7 9006 58 % % NN cord-005453-4057qib7 9006 59 ) ) -RRB- cord-005453-4057qib7 9006 60 patients patient NNS cord-005453-4057qib7 9006 61 . . . cord-005453-4057qib7 9007 1 HEV HEV NNP cord-005453-4057qib7 9007 2 infection infection NN cord-005453-4057qib7 9007 3 correlated correlate VBD cord-005453-4057qib7 9007 4 to to IN cord-005453-4057qib7 9007 5 elevated elevate VBN cord-005453-4057qib7 9007 6 ALT alt NN cord-005453-4057qib7 9007 7 > > XX cord-005453-4057qib7 9007 8 1.5 1.5 CD cord-005453-4057qib7 9007 9 ULN ULN NNP cord-005453-4057qib7 9007 10 , , , cord-005453-4057qib7 9007 11 OR or CC cord-005453-4057qib7 9007 12 8.3 8.3 CD cord-005453-4057qib7 9007 13 p=0 p=0 NNS cord-005453-4057qib7 9007 14 .02 .02 NFP cord-005453-4057qib7 9007 15 ) ) -RRB- cord-005453-4057qib7 9007 16 and and CC cord-005453-4057qib7 9007 17 > > XX cord-005453-4057qib7 9007 18 3 3 CD cord-005453-4057qib7 9007 19 ULN ULN NNP cord-005453-4057qib7 9007 20 , , , cord-005453-4057qib7 9007 21 p=0 p=0 NNP cord-005453-4057qib7 9007 22 .02 .02 NFP cord-005453-4057qib7 9007 23 ) ) -RRB- cord-005453-4057qib7 9007 24 at at IN cord-005453-4057qib7 9007 25 6 6 CD cord-005453-4057qib7 9007 26 months month NNS cord-005453-4057qib7 9007 27 , , , cord-005453-4057qib7 9007 28 but but CC cord-005453-4057qib7 9007 29 not not RB cord-005453-4057qib7 9007 30 at at IN cord-005453-4057qib7 9007 31 3 3 CD cord-005453-4057qib7 9007 32 months month NNS cord-005453-4057qib7 9007 33 , , , cord-005453-4057qib7 9007 34 after after IN cord-005453-4057qib7 9007 35 HSCT HSCT NNP cord-005453-4057qib7 9007 36 , , , cord-005453-4057qib7 9007 37 compared compare VBN cord-005453-4057qib7 9007 38 to to IN cord-005453-4057qib7 9007 39 HEV HEV NNP cord-005453-4057qib7 9007 40 RNA RNA NNP cord-005453-4057qib7 9007 41 negative negative JJ cord-005453-4057qib7 9007 42 controls control NNS cord-005453-4057qib7 9007 43 . . . cord-005453-4057qib7 9008 1 Conclusions conclusion NNS cord-005453-4057qib7 9008 2 : : : cord-005453-4057qib7 9009 1 HEV HEV NNP cord-005453-4057qib7 9009 2 infection infection NN cord-005453-4057qib7 9009 3 was be VBD cord-005453-4057qib7 9009 4 detected detect VBN cord-005453-4057qib7 9009 5 in in IN cord-005453-4057qib7 9009 6 3.1 3.1 CD cord-005453-4057qib7 9009 7 % % NN cord-005453-4057qib7 9009 8 of of IN cord-005453-4057qib7 9009 9 patients patient NNS cord-005453-4057qib7 9009 10 tested test VBN cord-005453-4057qib7 9009 11 at at IN cord-005453-4057qib7 9009 12 6 6 CD cord-005453-4057qib7 9009 13 months month NNS cord-005453-4057qib7 9009 14 after after IN cord-005453-4057qib7 9009 15 HSCT HSCT NNP cord-005453-4057qib7 9009 16 and and CC cord-005453-4057qib7 9009 17 was be VBD cord-005453-4057qib7 9009 18 correlated correlate VBN cord-005453-4057qib7 9009 19 to to IN cord-005453-4057qib7 9009 20 abnormal abnormal JJ cord-005453-4057qib7 9009 21 ALT alt NN cord-005453-4057qib7 9009 22 . . . cord-005453-4057qib7 9010 1 Spontaneous spontaneous JJ cord-005453-4057qib7 9010 2 clearance clearance NN cord-005453-4057qib7 9010 3 was be VBD cord-005453-4057qib7 9010 4 common common JJ cord-005453-4057qib7 9010 5 but but CC cord-005453-4057qib7 9010 6 one one CD cord-005453-4057qib7 9010 7 patient patient NN cord-005453-4057qib7 9010 8 died die VBD cord-005453-4057qib7 9010 9 in in IN cord-005453-4057qib7 9010 10 acute acute JJ cord-005453-4057qib7 9010 11 liver liver NN cord-005453-4057qib7 9010 12 failure failure NN cord-005453-4057qib7 9010 13 , , , cord-005453-4057qib7 9010 14 where where WRB cord-005453-4057qib7 9010 15 HEV HEV NNP cord-005453-4057qib7 9010 16 may may MD cord-005453-4057qib7 9010 17 have have VB cord-005453-4057qib7 9010 18 contributed contribute VBN cord-005453-4057qib7 9010 19 . . . cord-005453-4057qib7 9011 1 HEV HEV NNP cord-005453-4057qib7 9011 2 infection infection NN cord-005453-4057qib7 9011 3 is be VBZ cord-005453-4057qib7 9011 4 a a DT cord-005453-4057qib7 9011 5 differential differential JJ cord-005453-4057qib7 9011 6 diagnosis diagnosis NN cord-005453-4057qib7 9011 7 in in IN cord-005453-4057qib7 9011 8 patients patient NNS cord-005453-4057qib7 9011 9 with with IN cord-005453-4057qib7 9011 10 elevated elevated JJ cord-005453-4057qib7 9011 11 ALT alt NN cord-005453-4057qib7 9011 12 6 6 CD cord-005453-4057qib7 9011 13 months month NNS cord-005453-4057qib7 9011 14 after after IN cord-005453-4057qib7 9011 15 HSCT HSCT NNP cord-005453-4057qib7 9011 16 . . . cord-005453-4057qib7 9012 1 Disclosure disclosure NN cord-005453-4057qib7 9012 2 : : : cord-005453-4057qib7 9012 3 Nothing nothing NN cord-005453-4057qib7 9012 4 to to TO cord-005453-4057qib7 9012 5 declare declare VB cord-005453-4057qib7 9012 6 Monitoring monitoring NN cord-005453-4057qib7 9012 7 of of IN cord-005453-4057qib7 9012 8 T t NN cord-005453-4057qib7 9012 9 - - HYPH cord-005453-4057qib7 9012 10 cell cell NN cord-005453-4057qib7 9012 11 responses response NNS cord-005453-4057qib7 9012 12 to to IN cord-005453-4057qib7 9012 13 viral viral RB cord-005453-4057qib7 9012 14 - - HYPH cord-005453-4057qib7 9012 15 coded code VBN cord-005453-4057qib7 9012 16 antigens antigen NNS cord-005453-4057qib7 9012 17 in in IN cord-005453-4057qib7 9012 18 pediatric pediatric JJ cord-005453-4057qib7 9012 19 patients patient NNS cord-005453-4057qib7 9012 20 receiving receive VBG cord-005453-4057qib7 9012 21 TCRαβ TCRαβ NNP cord-005453-4057qib7 9012 22 - - HYPH cord-005453-4057qib7 9012 23 depleted deplete VBN cord-005453-4057qib7 9012 24 haplo haplo NN cord-005453-4057qib7 9012 25 - - HYPH cord-005453-4057qib7 9012 26 HSCT HSCT NNP cord-005453-4057qib7 9012 27 followed follow VBD cord-005453-4057qib7 9012 28 by by IN cord-005453-4057qib7 9012 29 BPX-501 BPX-501 NNP cord-005453-4057qib7 9013 1 cell cell NN cord-005453-4057qib7 9013 2 administration administration NN cord-005453-4057qib7 9013 3 Background Background NNP cord-005453-4057qib7 9013 4 : : : cord-005453-4057qib7 9013 5 αβ αβ NNP cord-005453-4057qib7 9013 6 T t NN cord-005453-4057qib7 9013 7 - - HYPH cord-005453-4057qib7 9013 8 cell cell NN cord-005453-4057qib7 9013 9 - - HYPH cord-005453-4057qib7 9013 10 depleted deplete VBN cord-005453-4057qib7 9013 11 haplo haplo NN cord-005453-4057qib7 9013 12 - - HYPH cord-005453-4057qib7 9013 13 HSCT HSCT NNP cord-005453-4057qib7 9013 14 is be VBZ cord-005453-4057qib7 9013 15 an an DT cord-005453-4057qib7 9013 16 effective effective JJ cord-005453-4057qib7 9013 17 option option NN cord-005453-4057qib7 9013 18 for for IN cord-005453-4057qib7 9013 19 children child NNS cord-005453-4057qib7 9013 20 with with IN cord-005453-4057qib7 9013 21 hematological hematological JJ cord-005453-4057qib7 9013 22 disorders disorder NNS cord-005453-4057qib7 9013 23 in in IN cord-005453-4057qib7 9013 24 need need NN cord-005453-4057qib7 9013 25 of of IN cord-005453-4057qib7 9013 26 an an DT cord-005453-4057qib7 9013 27 allograft allograft NN cord-005453-4057qib7 9013 28 . . . cord-005453-4057qib7 9014 1 However however RB cord-005453-4057qib7 9014 2 , , , cord-005453-4057qib7 9014 3 recovery recovery NN cord-005453-4057qib7 9014 4 of of IN cord-005453-4057qib7 9014 5 adaptive adaptive JJ cord-005453-4057qib7 9014 6 immunity immunity NN cord-005453-4057qib7 9014 7 is be VBZ cord-005453-4057qib7 9014 8 impaired impair VBN cord-005453-4057qib7 9014 9 in in IN cord-005453-4057qib7 9014 10 these these DT cord-005453-4057qib7 9014 11 patients patient NNS cord-005453-4057qib7 9014 12 . . . cord-005453-4057qib7 9015 1 Thus thus RB cord-005453-4057qib7 9015 2 , , , cord-005453-4057qib7 9015 3 in in IN cord-005453-4057qib7 9015 4 order order NN cord-005453-4057qib7 9015 5 to to TO cord-005453-4057qib7 9015 6 accelerate accelerate VB cord-005453-4057qib7 9015 7 immune immune JJ cord-005453-4057qib7 9015 8 reconstitution reconstitution NN cord-005453-4057qib7 9015 9 , , , cord-005453-4057qib7 9015 10 we -PRON- PRP cord-005453-4057qib7 9015 11 developed develop VBD cord-005453-4057qib7 9015 12 a a DT cord-005453-4057qib7 9015 13 novel novel JJ cord-005453-4057qib7 9015 14 approach approach NN cord-005453-4057qib7 9015 15 based base VBN cord-005453-4057qib7 9015 16 on on IN cord-005453-4057qib7 9015 17 post post JJ cord-005453-4057qib7 9015 18 - - JJ cord-005453-4057qib7 9015 19 transplant transplant JJ cord-005453-4057qib7 9015 20 infusion infusion NN cord-005453-4057qib7 9015 21 of of IN cord-005453-4057qib7 9015 22 a a DT cord-005453-4057qib7 9015 23 titrated titrate VBN cord-005453-4057qib7 9015 24 number number NN cord-005453-4057qib7 9015 25 of of IN cord-005453-4057qib7 9015 26 donor donor NN cord-005453-4057qib7 9015 27 T t NN cord-005453-4057qib7 9015 28 cells cell NNS cord-005453-4057qib7 9015 29 , , , cord-005453-4057qib7 9015 30 transduced transduce VBN cord-005453-4057qib7 9015 31 with with IN cord-005453-4057qib7 9015 32 the the DT cord-005453-4057qib7 9015 33 suicide suicide NN cord-005453-4057qib7 9015 34 gene gene NN cord-005453-4057qib7 9015 35 inducible inducible JJ cord-005453-4057qib7 9015 36 - - : cord-005453-4057qib7 9015 37 Caspase-9 Caspase-9 NNPS cord-005453-4057qib7 9015 38 , , , cord-005453-4057qib7 9015 39 iC9 ic9 FW cord-005453-4057qib7 9015 40 ( ( -LRB- cord-005453-4057qib7 9015 41 BPX-501 bpx-501 RB cord-005453-4057qib7 9015 42 cells cell NNS cord-005453-4057qib7 9015 43 , , , cord-005453-4057qib7 9015 44 Sponsor Sponsor NNP cord-005453-4057qib7 9015 45 Bellicum Bellicum NNP cord-005453-4057qib7 9015 46 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 9015 47 ® ® VBP cord-005453-4057qib7 9015 48 ; ; : cord-005453-4057qib7 9015 49 NCT02065869 NCT02065869 NNP cord-005453-4057qib7 9015 50 ) ) -RRB- cord-005453-4057qib7 9015 51 . . . cord-005453-4057qib7 9016 1 We -PRON- PRP cord-005453-4057qib7 9016 2 previously previously RB cord-005453-4057qib7 9016 3 reported report VBD cord-005453-4057qib7 9016 4 on on IN cord-005453-4057qib7 9016 5 immune immune JJ cord-005453-4057qib7 9016 6 recovery recovery NN cord-005453-4057qib7 9016 7 of of IN cord-005453-4057qib7 9016 8 108 108 CD cord-005453-4057qib7 9016 9 children child NNS cord-005453-4057qib7 9016 10 transplanted transplant VBN cord-005453-4057qib7 9016 11 at at IN cord-005453-4057qib7 9016 12 our -PRON- PRP$ cord-005453-4057qib7 9016 13 institution institution NN cord-005453-4057qib7 9016 14 , , , cord-005453-4057qib7 9016 15 showing show VBG cord-005453-4057qib7 9016 16 that that IN cord-005453-4057qib7 9016 17 BPX-501 BPX-501 NNP cord-005453-4057qib7 9016 18 cells cell NNS cord-005453-4057qib7 9016 19 infused infuse VBN cord-005453-4057qib7 9016 20 after after IN cord-005453-4057qib7 9016 21 αβ αβ FW cord-005453-4057qib7 9016 22 T t NN cord-005453-4057qib7 9016 23 - - HYPH cord-005453-4057qib7 9016 24 cell cell NN cord-005453-4057qib7 9016 25 - - HYPH cord-005453-4057qib7 9016 26 depleted deplete VBN cord-005453-4057qib7 9016 27 haplo haplo NN cord-005453-4057qib7 9016 28 - - HYPH cord-005453-4057qib7 9016 29 HSCT HSCT NNP cord-005453-4057qib7 9016 30 expand expand VBP cord-005453-4057qib7 9016 31 in in IN cord-005453-4057qib7 9016 32 - - HYPH cord-005453-4057qib7 9016 33 vivo vivo NN cord-005453-4057qib7 9016 34 and and CC cord-005453-4057qib7 9016 35 persist persist VB cord-005453-4057qib7 9016 36 over over IN cord-005453-4057qib7 9016 37 time time NN cord-005453-4057qib7 9016 38 , , , cord-005453-4057qib7 9016 39 contributing contribute VBG cord-005453-4057qib7 9016 40 to to TO cord-005453-4057qib7 9016 41 fasten fasten VB cord-005453-4057qib7 9016 42 adaptive adaptive JJ cord-005453-4057qib7 9016 43 immunity immunity NN cord-005453-4057qib7 9016 44 recovery recovery NN cord-005453-4057qib7 9016 45 ( ( -LRB- cord-005453-4057qib7 9016 46 Merli Merli NNP cord-005453-4057qib7 9016 47 , , , cord-005453-4057qib7 9016 48 ASH2017 ASH2017 NNP cord-005453-4057qib7 9016 49 ) ) -RRB- cord-005453-4057qib7 9016 50 . . . cord-005453-4057qib7 9017 1 Here here RB cord-005453-4057qib7 9017 2 , , , cord-005453-4057qib7 9017 3 we -PRON- PRP cord-005453-4057qib7 9017 4 report report VBP cord-005453-4057qib7 9017 5 the the DT cord-005453-4057qib7 9017 6 results result NNS cord-005453-4057qib7 9017 7 of of IN cord-005453-4057qib7 9017 8 lymphoproliferation lymphoproliferation NN cord-005453-4057qib7 9017 9 assay assay NN cord-005453-4057qib7 9017 10 to to IN cord-005453-4057qib7 9017 11 viral viral RB cord-005453-4057qib7 9017 12 - - HYPH cord-005453-4057qib7 9017 13 encoded encode VBN cord-005453-4057qib7 9017 14 antigens antigen NNS cord-005453-4057qib7 9017 15 to to TO cord-005453-4057qib7 9017 16 assess assess VB cord-005453-4057qib7 9017 17 Tcell Tcell NNP cord-005453-4057qib7 9017 18 function function NN cord-005453-4057qib7 9017 19 in in IN cord-005453-4057qib7 9017 20 patients patient NNS cord-005453-4057qib7 9017 21 transplanted transplant VBN cord-005453-4057qib7 9017 22 with with IN cord-005453-4057qib7 9017 23 this this DT cord-005453-4057qib7 9017 24 approach approach NN cord-005453-4057qib7 9017 25 . . . cord-005453-4057qib7 9018 1 Methods method NNS cord-005453-4057qib7 9018 2 : : : cord-005453-4057qib7 9018 3 We -PRON- PRP cord-005453-4057qib7 9018 4 evaluated evaluate VBD cord-005453-4057qib7 9018 5 142 142 CD cord-005453-4057qib7 9018 6 children child NNS cord-005453-4057qib7 9018 7 , , , cord-005453-4057qib7 9018 8 78 78 CD cord-005453-4057qib7 9018 9 male male NN cord-005453-4057qib7 9018 10 and and CC cord-005453-4057qib7 9018 11 64 64 CD cord-005453-4057qib7 9018 12 female female NN cord-005453-4057qib7 9018 13 . . . cord-005453-4057qib7 9019 1 Median median JJ cord-005453-4057qib7 9019 2 age age NN cord-005453-4057qib7 9019 3 at at IN cord-005453-4057qib7 9019 4 transplant transplant NN cord-005453-4057qib7 9019 5 was be VBD cord-005453-4057qib7 9019 6 5.7 5.7 CD cord-005453-4057qib7 9019 7 years year NNS cord-005453-4057qib7 9020 1 ( ( -LRB- cord-005453-4057qib7 9020 2 range range NN cord-005453-4057qib7 9020 3 0 0 NFP cord-005453-4057qib7 9020 4 . . . cord-005453-4057qib7 9021 1 [ [ -LRB- cord-005453-4057qib7 9021 2 3 3 CD cord-005453-4057qib7 9021 3 ] ] -RRB- cord-005453-4057qib7 9021 4 [ [ -LRB- cord-005453-4057qib7 9021 5 4 4 CD cord-005453-4057qib7 9021 6 ] ] -RRB- cord-005453-4057qib7 9021 7 [ [ -LRB- cord-005453-4057qib7 9021 8 5 5 CD cord-005453-4057qib7 9021 9 ] ] -RRB- cord-005453-4057qib7 9021 10 [ [ -LRB- cord-005453-4057qib7 9021 11 6 6 CD cord-005453-4057qib7 9021 12 ] ] -RRB- cord-005453-4057qib7 9021 13 [ [ -LRB- cord-005453-4057qib7 9021 14 7 7 CD cord-005453-4057qib7 9021 15 ] ] -RRB- cord-005453-4057qib7 9022 1 [ [ -LRB- cord-005453-4057qib7 9022 2 8 8 CD cord-005453-4057qib7 9022 3 ] ] -RRB- cord-005453-4057qib7 9022 4 [ [ -LRB- cord-005453-4057qib7 9022 5 9 9 CD cord-005453-4057qib7 9022 6 ] ] -RRB- cord-005453-4057qib7 9022 7 [ [ -LRB- cord-005453-4057qib7 9022 8 10 10 CD cord-005453-4057qib7 9022 9 ] ] -RRB- cord-005453-4057qib7 9022 10 [ [ -LRB- cord-005453-4057qib7 9022 11 11 11 CD cord-005453-4057qib7 9022 12 ] ] -RRB- cord-005453-4057qib7 9023 1 [ [ -LRB- cord-005453-4057qib7 9023 2 12 12 CD cord-005453-4057qib7 9023 3 ] ] -RRB- cord-005453-4057qib7 9023 4 [ [ -LRB- cord-005453-4057qib7 9023 5 13 13 CD cord-005453-4057qib7 9023 6 ] ] -RRB- cord-005453-4057qib7 9024 1 [ [ -LRB- cord-005453-4057qib7 9024 2 14 14 CD cord-005453-4057qib7 9024 3 ] ] -RRB- cord-005453-4057qib7 9025 1 [ [ -LRB- cord-005453-4057qib7 9025 2 15 15 CD cord-005453-4057qib7 9025 3 ] ] -RRB- cord-005453-4057qib7 9025 4 [ [ -LRB- cord-005453-4057qib7 9025 5 16 16 CD cord-005453-4057qib7 9025 6 ] ] -RRB- cord-005453-4057qib7 9025 7 [ [ -LRB- cord-005453-4057qib7 9025 8 17 17 CD cord-005453-4057qib7 9025 9 ] ] -RRB- cord-005453-4057qib7 9025 10 [ [ -LRB- cord-005453-4057qib7 9025 11 18 18 CD cord-005453-4057qib7 9025 12 ] ] -RRB- cord-005453-4057qib7 9025 13 . . . cord-005453-4057qib7 9026 1 Patients patient NNS cord-005453-4057qib7 9026 2 had have VBD cord-005453-4057qib7 9026 3 either either CC cord-005453-4057qib7 9026 4 malignant malignant JJ cord-005453-4057qib7 9026 5 ( ( -LRB- cord-005453-4057qib7 9026 6 69 69 CD cord-005453-4057qib7 9026 7 children child NNS cord-005453-4057qib7 9026 8 ) ) -RRB- cord-005453-4057qib7 9026 9 and and CC cord-005453-4057qib7 9026 10 nonmalignant nonmalignant NNP cord-005453-4057qib7 9026 11 ( ( -LRB- cord-005453-4057qib7 9026 12 73 73 CD cord-005453-4057qib7 9026 13 ) ) -RRB- cord-005453-4057qib7 9026 14 disorders disorder NNS cord-005453-4057qib7 9026 15 . . . cord-005453-4057qib7 9027 1 No no DT cord-005453-4057qib7 9027 2 patient patient NN cord-005453-4057qib7 9027 3 was be VBD cord-005453-4057qib7 9027 4 given give VBN cord-005453-4057qib7 9027 5 any any DT cord-005453-4057qib7 9027 6 posttransplant posttransplant NN cord-005453-4057qib7 9027 7 graft graft NN cord-005453-4057qib7 9027 8 - - HYPH cord-005453-4057qib7 9027 9 versus versus IN cord-005453-4057qib7 9027 10 - - HYPH cord-005453-4057qib7 9027 11 host host NN cord-005453-4057qib7 9027 12 disease disease NN cord-005453-4057qib7 9027 13 prophylaxis prophylaxis NN cord-005453-4057qib7 9027 14 . . . cord-005453-4057qib7 9028 1 Nine nine CD cord-005453-4057qib7 9028 2 children child NNS cord-005453-4057qib7 9028 3 were be VBD cord-005453-4057qib7 9028 4 enrolled enrol VBN cord-005453-4057qib7 9028 5 in in IN cord-005453-4057qib7 9028 6 the the DT cord-005453-4057qib7 9028 7 phase phase NN cord-005453-4057qib7 9028 8 I -PRON- PRP cord-005453-4057qib7 9028 9 portion portion NN cord-005453-4057qib7 9028 10 of of IN cord-005453-4057qib7 9028 11 the the DT cord-005453-4057qib7 9028 12 trial trial NN cord-005453-4057qib7 9028 13 consisting consist VBG cord-005453-4057qib7 9028 14 of of IN cord-005453-4057qib7 9028 15 3 3 CD cord-005453-4057qib7 9028 16 cohorts cohort NNS cord-005453-4057qib7 9028 17 receiving receive VBG cord-005453-4057qib7 9028 18 escalating escalate VBG cord-005453-4057qib7 9028 19 doses dose NNS cord-005453-4057qib7 9028 20 of of IN cord-005453-4057qib7 9028 21 BPX-501 BPX-501 NNP cord-005453-4057qib7 9028 22 cells cell NNS cord-005453-4057qib7 9028 23 . . . cord-005453-4057qib7 9029 1 The the DT cord-005453-4057qib7 9029 2 remaining remain VBG cord-005453-4057qib7 9029 3 133 133 CD cord-005453-4057qib7 9029 4 patients patient NNS cord-005453-4057qib7 9029 5 ( ( -LRB- cord-005453-4057qib7 9029 6 phase phase NN cord-005453-4057qib7 9029 7 II II NNP cord-005453-4057qib7 9029 8 portion portion NN cord-005453-4057qib7 9029 9 ) ) -RRB- cord-005453-4057qib7 9029 10 received receive VBD cord-005453-4057qib7 9029 11 the the DT cord-005453-4057qib7 9029 12 recommended recommend VBN cord-005453-4057qib7 9029 13 dose dose NN cord-005453-4057qib7 9029 14 of of IN cord-005453-4057qib7 9029 15 1x10 1x10 CD cord-005453-4057qib7 9029 16 6 6 CD cord-005453-4057qib7 9029 17 BPX-501 BPX-501 NNP cord-005453-4057qib7 9029 18 cells cell NNS cord-005453-4057qib7 9029 19 / / SYM cord-005453-4057qib7 9029 20 kg kg NNS cord-005453-4057qib7 9029 21 identified identify VBN cord-005453-4057qib7 9029 22 in in IN cord-005453-4057qib7 9029 23 phase phase NN cord-005453-4057qib7 9030 1 I. I. NNP cord-005453-4057qib7 9030 2 BPX-501 BPX-501 NNP cord-005453-4057qib7 9030 3 cells cell NNS cord-005453-4057qib7 9030 4 were be VBD cord-005453-4057qib7 9030 5 infused infuse VBN cord-005453-4057qib7 9030 6 at at IN cord-005453-4057qib7 9030 7 a a DT cord-005453-4057qib7 9030 8 median median NN cord-005453-4057qib7 9030 9 of of IN cord-005453-4057qib7 9030 10 17 17 CD cord-005453-4057qib7 9030 11 days day NNS cord-005453-4057qib7 9030 12 post post NN cord-005453-4057qib7 9030 13 - - JJ cord-005453-4057qib7 9030 14 HSCT HSCT NNP cord-005453-4057qib7 9030 15 ( ( -LRB- cord-005453-4057qib7 9030 16 range range NNP cord-005453-4057qib7 9030 17 10 10 CD cord-005453-4057qib7 9030 18 - - SYM cord-005453-4057qib7 9030 19 82 82 CD cord-005453-4057qib7 9030 20 ) ) -RRB- cord-005453-4057qib7 9030 21 . . . cord-005453-4057qib7 9031 1 Antigendriven Antigendriven NNP cord-005453-4057qib7 9031 2 activation activation NN cord-005453-4057qib7 9031 3 of of IN cord-005453-4057qib7 9031 4 peripheral peripheral JJ cord-005453-4057qib7 9031 5 mononuclear mononuclear JJ cord-005453-4057qib7 9031 6 cells cell NNS cord-005453-4057qib7 9031 7 was be VBD cord-005453-4057qib7 9031 8 evaluated evaluate VBN cord-005453-4057qib7 9031 9 by by IN cord-005453-4057qib7 9031 10 lymphoproliferation lymphoproliferation NN cord-005453-4057qib7 9031 11 assay assay NN cord-005453-4057qib7 9031 12 with with IN cord-005453-4057qib7 9031 13 3 3 CD cord-005453-4057qib7 9031 14 H h NN cord-005453-4057qib7 9031 15 - - HYPH cord-005453-4057qib7 9031 16 thymidine thymidine NN cord-005453-4057qib7 9031 17 pulsing pulse VBG cord-005453-4057qib7 9031 18 at at IN cord-005453-4057qib7 9031 19 d+4 d+4 NNS cord-005453-4057qib7 9031 20 and and CC cord-005453-4057qib7 9031 21 harvesting harvest VBG cord-005453-4057qib7 9031 22 at at IN cord-005453-4057qib7 9031 23 d+5 d+5 CD cord-005453-4057qib7 9031 24 . . . cord-005453-4057qib7 9032 1 Stimuli stimulus NNS cord-005453-4057qib7 9032 2 included include VBD cord-005453-4057qib7 9032 3 PHA PHA NNP cord-005453-4057qib7 9032 4 or or CC cord-005453-4057qib7 9032 5 CMV CMV NNP cord-005453-4057qib7 9032 6 , , , cord-005453-4057qib7 9032 7 EBV EBV NNP cord-005453-4057qib7 9032 8 and and CC cord-005453-4057qib7 9032 9 AdV adv NN cord-005453-4057qib7 9032 10 whole whole JJ cord-005453-4057qib7 9032 11 viral viral JJ cord-005453-4057qib7 9032 12 lysate lysate NN cord-005453-4057qib7 9032 13 . . . cord-005453-4057qib7 9033 1 Results result NNS cord-005453-4057qib7 9033 2 are be VBP cord-005453-4057qib7 9033 3 given give VBN cord-005453-4057qib7 9033 4 as as IN cord-005453-4057qib7 9033 5 stimulation stimulation NN cord-005453-4057qib7 9033 6 indexes index NNS cord-005453-4057qib7 9033 7 ( ( -LRB- cord-005453-4057qib7 9033 8 SI SI NNP cord-005453-4057qib7 9033 9 , , , cord-005453-4057qib7 9033 10 cpm cpm NNP cord-005453-4057qib7 9033 11 stimulated stimulate VBD cord-005453-4057qib7 9033 12 sample sample NN cord-005453-4057qib7 9033 13 / / SYM cord-005453-4057qib7 9033 14 cpm cpm NNP cord-005453-4057qib7 9033 15 unstimulated unstimulated JJ cord-005453-4057qib7 9033 16 control control NN cord-005453-4057qib7 9033 17 ) ) -RRB- cord-005453-4057qib7 9033 18 . . . cord-005453-4057qib7 9034 1 Thresholds threshold NNS cord-005453-4057qib7 9034 2 for for IN cord-005453-4057qib7 9034 3 positive positive JJ cord-005453-4057qib7 9034 4 response response NN cord-005453-4057qib7 9034 5 were be VBD cord-005453-4057qib7 9034 6 arbitrarily arbitrarily RB cord-005453-4057qib7 9034 7 set set VBN cord-005453-4057qib7 9034 8 at at IN cord-005453-4057qib7 9034 9 SI>3 SI>3 NNP cord-005453-4057qib7 9034 10 for for IN cord-005453-4057qib7 9034 11 viral viral RB cord-005453-4057qib7 9034 12 - - HYPH cord-005453-4057qib7 9034 13 encoded encode VBN cord-005453-4057qib7 9034 14 antigens antigen NNS cord-005453-4057qib7 9034 15 and and CC cord-005453-4057qib7 9034 16 at at IN cord-005453-4057qib7 9034 17 SI>5 SI>5 NNP cord-005453-4057qib7 9034 18 for for IN cord-005453-4057qib7 9034 19 mitogenic mitogenic JJ cord-005453-4057qib7 9034 20 stimulation stimulation NN cord-005453-4057qib7 9034 21 with with IN cord-005453-4057qib7 9034 22 PHA PHA NNP cord-005453-4057qib7 9034 23 . . . cord-005453-4057qib7 9035 1 Fractions fraction NNS cord-005453-4057qib7 9035 2 of of IN cord-005453-4057qib7 9035 3 responders responder NNS cord-005453-4057qib7 9035 4 are be VBP cord-005453-4057qib7 9035 5 indicated indicate VBN cord-005453-4057qib7 9035 6 in in IN cord-005453-4057qib7 9035 7 the the DT cord-005453-4057qib7 9035 8 figure figure NN cord-005453-4057qib7 9035 9 . . . cord-005453-4057qib7 9036 1 Results result NNS cord-005453-4057qib7 9036 2 : : : cord-005453-4057qib7 9037 1 Patients patient NNS cord-005453-4057qib7 9037 2 were be VBD cord-005453-4057qib7 9037 3 analyzed analyze VBN cord-005453-4057qib7 9037 4 from from IN cord-005453-4057qib7 9037 5 d+30 d+30 NN cord-005453-4057qib7 9037 6 to to IN cord-005453-4057qib7 9037 7 d+720 d+720 NNP cord-005453-4057qib7 9037 8 post post VB cord-005453-4057qib7 9037 9 - - JJ cord-005453-4057qib7 9037 10 HSCT HSCT NNP cord-005453-4057qib7 9037 11 . . . cord-005453-4057qib7 9038 1 PHA PHA NNP cord-005453-4057qib7 9038 2 responders responder NNS cord-005453-4057qib7 9038 3 ( ( -LRB- cord-005453-4057qib7 9038 4 A a NN cord-005453-4057qib7 9038 5 ) ) -RRB- cord-005453-4057qib7 9038 6 increased increase VBD cord-005453-4057qib7 9038 7 to to IN cord-005453-4057qib7 9038 8 80 80 CD cord-005453-4057qib7 9038 9 % % NN cord-005453-4057qib7 9038 10 , , , cord-005453-4057qib7 9038 11 while while IN cord-005453-4057qib7 9038 12 CMV CMV NNP cord-005453-4057qib7 9038 13 ( ( -LRB- cord-005453-4057qib7 9038 14 B b NN cord-005453-4057qib7 9038 15 ) ) -RRB- cord-005453-4057qib7 9038 16 , , , cord-005453-4057qib7 9038 17 EBV EBV NNP cord-005453-4057qib7 9038 18 ( ( -LRB- cord-005453-4057qib7 9038 19 C C NNP cord-005453-4057qib7 9038 20 ) ) -RRB- cord-005453-4057qib7 9038 21 and and CC cord-005453-4057qib7 9038 22 AdV AdV NNP cord-005453-4057qib7 9038 23 ( ( -LRB- cord-005453-4057qib7 9038 24 D D NNP cord-005453-4057qib7 9038 25 ) ) -RRB- cord-005453-4057qib7 9038 26 responders responder NNS cord-005453-4057qib7 9038 27 were be VBD cord-005453-4057qib7 9038 28 61 61 CD cord-005453-4057qib7 9038 29 % % NN cord-005453-4057qib7 9038 30 , , , cord-005453-4057qib7 9038 31 52 52 CD cord-005453-4057qib7 9038 32 % % NN cord-005453-4057qib7 9038 33 and and CC cord-005453-4057qib7 9038 34 61 61 CD cord-005453-4057qib7 9038 35 % % NN cord-005453-4057qib7 9038 36 at at IN cord-005453-4057qib7 9038 37 2 2 CD cord-005453-4057qib7 9038 38 years year NNS cord-005453-4057qib7 9038 39 after after IN cord-005453-4057qib7 9038 40 haplo haplo NN cord-005453-4057qib7 9038 41 - - HYPH cord-005453-4057qib7 9038 42 HSCT HSCT NNP cord-005453-4057qib7 9038 43 . . . cord-005453-4057qib7 9039 1 Responses response NNS cord-005453-4057qib7 9039 2 to to IN cord-005453-4057qib7 9039 3 EBV EBV NNP cord-005453-4057qib7 9039 4 and and CC cord-005453-4057qib7 9039 5 AdV adv NN cord-005453-4057qib7 9039 6 antigens antigen NNS cord-005453-4057qib7 9039 7 were be VBD cord-005453-4057qib7 9039 8 slightly slightly RB cord-005453-4057qib7 9039 9 delayed delay VBN cord-005453-4057qib7 9039 10 but but CC cord-005453-4057qib7 9039 11 improved improve VBN cord-005453-4057qib7 9039 12 over over IN cord-005453-4057qib7 9039 13 time time NN cord-005453-4057qib7 9039 14 . . . cord-005453-4057qib7 9040 1 Responses response NNS cord-005453-4057qib7 9040 2 to to IN cord-005453-4057qib7 9040 3 PHA PHA NNP cord-005453-4057qib7 9040 4 and and CC cord-005453-4057qib7 9040 5 to to IN cord-005453-4057qib7 9040 6 CMV CMV NNP cord-005453-4057qib7 9040 7 ( ( -LRB- cord-005453-4057qib7 9040 8 E E NNP cord-005453-4057qib7 9040 9 , , , cord-005453-4057qib7 9040 10 F F NNP cord-005453-4057qib7 9040 11 ) ) -RRB- cord-005453-4057qib7 9040 12 were be VBD cord-005453-4057qib7 9040 13 analyzed analyze VBN cord-005453-4057qib7 9040 14 in in IN cord-005453-4057qib7 9040 15 the the DT cord-005453-4057qib7 9040 16 CMV CMV NNP cord-005453-4057qib7 9040 17 - - HYPH cord-005453-4057qib7 9040 18 reactivating reactivate VBG cord-005453-4057qib7 9040 19 and and CC cord-005453-4057qib7 9040 20 CMV CMV NNP cord-005453-4057qib7 9040 21 - - HYPH cord-005453-4057qib7 9040 22 non non JJ cord-005453-4057qib7 9040 23 reactivating reactivate VBG cord-005453-4057qib7 9040 24 groups group NNS cord-005453-4057qib7 9041 1 ( ( -LRB- cord-005453-4057qib7 9041 2 CMV CMV NNP cord-005453-4057qib7 9041 3 - - HYPH cord-005453-4057qib7 9041 4 yes yes NNP cord-005453-4057qib7 9041 5 / / SYM cord-005453-4057qib7 9041 6 CMV CMV NNP cord-005453-4057qib7 9041 7 - - HYPH cord-005453-4057qib7 9041 8 no no NN cord-005453-4057qib7 9041 9 ) ) -RRB- cord-005453-4057qib7 9041 10 . . . cord-005453-4057qib7 9042 1 Significant significant JJ cord-005453-4057qib7 9042 2 differences difference NNS cord-005453-4057qib7 9042 3 in in IN cord-005453-4057qib7 9042 4 PHA PHA NNP cord-005453-4057qib7 9042 5 response response NN cord-005453-4057qib7 9042 6 were be VBD cord-005453-4057qib7 9042 7 observed observe VBN cord-005453-4057qib7 9042 8 at at IN cord-005453-4057qib7 9042 9 d+60 d+60 NNS cord-005453-4057qib7 9042 10 and and CC cord-005453-4057qib7 9042 11 d+270 d+270 NN cord-005453-4057qib7 9042 12 . . . cord-005453-4057qib7 9043 1 Moreover moreover RB cord-005453-4057qib7 9043 2 , , , cord-005453-4057qib7 9043 3 increased increase VBD cord-005453-4057qib7 9043 4 CMV CMV NNP cord-005453-4057qib7 9043 5 responses response NNS cord-005453-4057qib7 9043 6 were be VBD cord-005453-4057qib7 9043 7 observed observe VBN cord-005453-4057qib7 9043 8 in in IN cord-005453-4057qib7 9043 9 CMVreactivators cmvreactivator NNS cord-005453-4057qib7 9043 10 at at IN cord-005453-4057qib7 9043 11 d+270 d+270 CD cord-005453-4057qib7 9043 12 , , , cord-005453-4057qib7 9043 13 d+360 d+360 NNP cord-005453-4057qib7 9043 14 and and CC cord-005453-4057qib7 9043 15 d+720 d+720 NNS cord-005453-4057qib7 9043 16 , , , cord-005453-4057qib7 9043 17 with with IN cord-005453-4057qib7 9043 18 approximately approximately RB cord-005453-4057qib7 9043 19 100 100 CD cord-005453-4057qib7 9043 20 % % NN cord-005453-4057qib7 9043 21 of of IN cord-005453-4057qib7 9043 22 responders responder NNS cord-005453-4057qib7 9043 23 at at IN cord-005453-4057qib7 9043 24 d+720 d+720 NNP cord-005453-4057qib7 9043 25 , , , cord-005453-4057qib7 9043 26 as as IN cord-005453-4057qib7 9043 27 opposed oppose VBN cord-005453-4057qib7 9043 28 to to IN cord-005453-4057qib7 9043 29 CMVnon CMVnon NNP cord-005453-4057qib7 9043 30 reactivators reactivator NNS cord-005453-4057qib7 9043 31 which which WDT cord-005453-4057qib7 9043 32 comprised comprise VBD cord-005453-4057qib7 9043 33 50 50 CD cord-005453-4057qib7 9043 34 % % NN cord-005453-4057qib7 9043 35 responders responder NNS cord-005453-4057qib7 9043 36 . . . cord-005453-4057qib7 9044 1 Neither neither DT cord-005453-4057qib7 9044 2 primary primary JJ cord-005453-4057qib7 9044 3 disease disease NN cord-005453-4057qib7 9044 4 , , , cord-005453-4057qib7 9044 5 age age NN cord-005453-4057qib7 9044 6 nor nor CC cord-005453-4057qib7 9044 7 TBI TBI NNP cord-005453-4057qib7 9044 8 during during IN cord-005453-4057qib7 9044 9 the the DT cord-005453-4057qib7 9044 10 conditioning conditioning NN cord-005453-4057qib7 9044 11 regimen regimen NN cord-005453-4057qib7 9044 12 influenced influence VBD cord-005453-4057qib7 9044 13 proliferative proliferative JJ cord-005453-4057qib7 9044 14 capacity capacity NN cord-005453-4057qib7 9044 15 of of IN cord-005453-4057qib7 9044 16 the the DT cord-005453-4057qib7 9044 17 two two CD cord-005453-4057qib7 9044 18 subgroups subgroup NNS cord-005453-4057qib7 9044 19 ( ( -LRB- cord-005453-4057qib7 9044 20 not not RB cord-005453-4057qib7 9044 21 shown show VBN cord-005453-4057qib7 9044 22 ) ) -RRB- cord-005453-4057qib7 9044 23 . . . cord-005453-4057qib7 9045 1 Conclusions conclusion NNS cord-005453-4057qib7 9045 2 : : : cord-005453-4057qib7 9046 1 We -PRON- PRP cord-005453-4057qib7 9046 2 showed show VBD cord-005453-4057qib7 9046 3 a a DT cord-005453-4057qib7 9046 4 rapid rapid JJ cord-005453-4057qib7 9046 5 recovery recovery NN cord-005453-4057qib7 9046 6 over over IN cord-005453-4057qib7 9046 7 time time NN cord-005453-4057qib7 9046 8 of of IN cord-005453-4057qib7 9046 9 T t NN cord-005453-4057qib7 9046 10 - - HYPH cord-005453-4057qib7 9046 11 cell cell NN cord-005453-4057qib7 9046 12 function function NN cord-005453-4057qib7 9046 13 after after IN cord-005453-4057qib7 9046 14 αβ αβ XX cord-005453-4057qib7 9046 15 T t NN cord-005453-4057qib7 9046 16 - - HYPH cord-005453-4057qib7 9046 17 cell cell NN cord-005453-4057qib7 9046 18 - - HYPH cord-005453-4057qib7 9046 19 depleted deplete VBN cord-005453-4057qib7 9046 20 haplo haplo NN cord-005453-4057qib7 9046 21 - - HYPH cord-005453-4057qib7 9046 22 HSCT HSCT NNP cord-005453-4057qib7 9046 23 followed follow VBD cord-005453-4057qib7 9046 24 by by IN cord-005453-4057qib7 9046 25 BPX-501 BPX-501 NNP cord-005453-4057qib7 9046 26 cells cell NNS cord-005453-4057qib7 9046 27 administration administration NN cord-005453-4057qib7 9046 28 . . . cord-005453-4057qib7 9047 1 When when WRB cord-005453-4057qib7 9047 2 patients patient NNS cord-005453-4057qib7 9047 3 were be VBD cord-005453-4057qib7 9047 4 grouped group VBN cord-005453-4057qib7 9047 5 according accord VBG cord-005453-4057qib7 9047 6 to to IN cord-005453-4057qib7 9047 7 CMV CMV NNP cord-005453-4057qib7 9047 8 reactivation reactivation NN cord-005453-4057qib7 9047 9 ( ( -LRB- cord-005453-4057qib7 9047 10 previously previously RB cord-005453-4057qib7 9047 11 demonstrated demonstrate VBN cord-005453-4057qib7 9047 12 as as IN cord-005453-4057qib7 9047 13 a a DT cord-005453-4057qib7 9047 14 strong strong JJ cord-005453-4057qib7 9047 15 driver driver NN cord-005453-4057qib7 9047 16 of of IN cord-005453-4057qib7 9047 17 immune immune JJ cord-005453-4057qib7 9047 18 reconstitution reconstitution NN cord-005453-4057qib7 9047 19 ) ) -RRB- cord-005453-4057qib7 9047 20 , , , cord-005453-4057qib7 9047 21 a a DT cord-005453-4057qib7 9047 22 significant significant JJ cord-005453-4057qib7 9047 23 difference difference NN cord-005453-4057qib7 9047 24 in in IN cord-005453-4057qib7 9047 25 the the DT cord-005453-4057qib7 9047 26 number number NN cord-005453-4057qib7 9047 27 of of IN cord-005453-4057qib7 9047 28 responders responder NNS cord-005453-4057qib7 9047 29 among among IN cord-005453-4057qib7 9047 30 the the DT cord-005453-4057qib7 9047 31 patients patient NNS cord-005453-4057qib7 9047 32 experiencing experience VBG cord-005453-4057qib7 9047 33 viral viral JJ cord-005453-4057qib7 9047 34 reactivation reactivation NN cord-005453-4057qib7 9047 35 was be VBD cord-005453-4057qib7 9047 36 observed observe VBN cord-005453-4057qib7 9047 37 using use VBG cord-005453-4057qib7 9047 38 the the DT cord-005453-4057qib7 9047 39 CMV CMV NNP cord-005453-4057qib7 9047 40 lysate lysate NN cord-005453-4057qib7 9047 41 only only RB cord-005453-4057qib7 9047 42 but but CC cord-005453-4057qib7 9047 43 not not RB cord-005453-4057qib7 9047 44 the the DT cord-005453-4057qib7 9047 45 immunodominant immunodominant NNP cord-005453-4057qib7 9047 46 pp65 pp65 NNP cord-005453-4057qib7 9047 47 protein protein NNP cord-005453-4057qib7 9047 48 ( ( -LRB- cord-005453-4057qib7 9047 49 not not RB cord-005453-4057qib7 9047 50 shown show VBN cord-005453-4057qib7 9047 51 ) ) -RRB- cord-005453-4057qib7 9047 52 , , , cord-005453-4057qib7 9047 53 suggesting suggest VBG cord-005453-4057qib7 9047 54 that that IN cord-005453-4057qib7 9047 55 other other JJ cord-005453-4057qib7 9047 56 viral viral JJ cord-005453-4057qib7 9047 57 antigens antigen NNS cord-005453-4057qib7 9047 58 account account NN cord-005453-4057qib7 9047 59 for for IN cord-005453-4057qib7 9047 60 increased increase VBN cord-005453-4057qib7 9047 61 T t NN cord-005453-4057qib7 9047 62 - - HYPH cord-005453-4057qib7 9047 63 cell cell NN cord-005453-4057qib7 9047 64 responses response NNS cord-005453-4057qib7 9047 65 . . . cord-005453-4057qib7 9048 1 Results result NNS cord-005453-4057qib7 9048 2 of of IN cord-005453-4057qib7 9048 3 T t NN cord-005453-4057qib7 9048 4 - - HYPH cord-005453-4057qib7 9048 5 cell cell NN cord-005453-4057qib7 9048 6 function function NN cord-005453-4057qib7 9048 7 after after IN cord-005453-4057qib7 9048 8 BPX BPX NNP cord-005453-4057qib7 9048 9 administration administration NN cord-005453-4057qib7 9048 10 complements complement VBZ cord-005453-4057qib7 9048 11 the the DT cord-005453-4057qib7 9048 12 phenotypic phenotypic JJ cord-005453-4057qib7 9048 13 data datum NNS cord-005453-4057qib7 9048 14 we -PRON- PRP cord-005453-4057qib7 9048 15 already already RB cord-005453-4057qib7 9048 16 reported report VBD cord-005453-4057qib7 9048 17 . . . cord-005453-4057qib7 9049 1 Clinical clinical JJ cord-005453-4057qib7 9049 2 Trial Trial NNP cord-005453-4057qib7 9049 3 Registry Registry NNP cord-005453-4057qib7 9049 4 : : : cord-005453-4057qib7 9050 1 NCT02065869 NCT02065869 NNP cord-005453-4057qib7 9050 2 Disclosure Disclosure NNP cord-005453-4057qib7 9050 3 : : : cord-005453-4057qib7 9050 4 Nothing nothing NN cord-005453-4057qib7 9050 5 to to TO cord-005453-4057qib7 9050 6 declare declare VB cord-005453-4057qib7 9050 7 . . . cord-005453-4057qib7 9051 1 Background background NN cord-005453-4057qib7 9051 2 : : : cord-005453-4057qib7 9052 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 9052 2 ( ( -LRB- cord-005453-4057qib7 9052 3 CMV CMV NNP cord-005453-4057qib7 9052 4 ) ) -RRB- cord-005453-4057qib7 9052 5 is be VBZ cord-005453-4057qib7 9052 6 associated associate VBN cord-005453-4057qib7 9052 7 with with IN cord-005453-4057qib7 9052 8 significant significant JJ cord-005453-4057qib7 9052 9 morbidity morbidity NN cord-005453-4057qib7 9052 10 and and CC cord-005453-4057qib7 9052 11 mortality mortality NN cord-005453-4057qib7 9052 12 in in IN cord-005453-4057qib7 9052 13 allogeneic allogeneic JJ cord-005453-4057qib7 9052 14 hematopoietic hematopoietic JJ cord-005453-4057qib7 9052 15 cell cell NN cord-005453-4057qib7 9052 16 transplantation transplantation NN cord-005453-4057qib7 9052 17 ( ( -LRB- cord-005453-4057qib7 9052 18 allo allo NN cord-005453-4057qib7 9052 19 - - HYPH cord-005453-4057qib7 9052 20 HCT HCT NNP cord-005453-4057qib7 9052 21 ) ) -RRB- cord-005453-4057qib7 9052 22 patients patient NNS cord-005453-4057qib7 9052 23 ( ( -LRB- cord-005453-4057qib7 9052 24 pts pts NNP cord-005453-4057qib7 9052 25 ) ) -RRB- cord-005453-4057qib7 9052 26 . . . cord-005453-4057qib7 9053 1 Cumulative cumulative JJ cord-005453-4057qib7 9053 2 incidence incidence NN cord-005453-4057qib7 9053 3 of of IN cord-005453-4057qib7 9053 4 CMV CMV NNP cord-005453-4057qib7 9053 5 infection infection NN cord-005453-4057qib7 9053 6 in in IN cord-005453-4057qib7 9053 7 high high JJ cord-005453-4057qib7 9053 8 - - HYPH cord-005453-4057qib7 9053 9 risk risk NN cord-005453-4057qib7 9053 10 patients patient NNS cord-005453-4057qib7 9053 11 such such JJ cord-005453-4057qib7 9053 12 as as IN cord-005453-4057qib7 9053 13 CD34-selected cd34-selected CD cord-005453-4057qib7 9053 14 or or CC cord-005453-4057qib7 9053 15 haploidentical haploidentical JJ cord-005453-4057qib7 9053 16 HCT HCT NNP cord-005453-4057qib7 9053 17 have have VBP cord-005453-4057qib7 9053 18 been be VBN cord-005453-4057qib7 9053 19 reported report VBN cord-005453-4057qib7 9053 20 as as RB cord-005453-4057qib7 9053 21 high high JJ cord-005453-4057qib7 9053 22 as as IN cord-005453-4057qib7 9053 23 61.8 61.8 CD cord-005453-4057qib7 9053 24 - - HYPH cord-005453-4057qib7 9053 25 84.5 84.5 CD cord-005453-4057qib7 9053 26 % % NN cord-005453-4057qib7 9053 27 and and CC cord-005453-4057qib7 9053 28 53 53 CD cord-005453-4057qib7 9053 29 - - SYM cord-005453-4057qib7 9053 30 81 81 CD cord-005453-4057qib7 9053 31 % % NN cord-005453-4057qib7 9053 32 , , , cord-005453-4057qib7 9053 33 respectively respectively RB cord-005453-4057qib7 9053 34 . . . cord-005453-4057qib7 9054 1 Letermovir Letermovir NNP cord-005453-4057qib7 9054 2 ( ( -LRB- cord-005453-4057qib7 9054 3 LTV LTV NNP cord-005453-4057qib7 9054 4 ) ) -RRB- cord-005453-4057qib7 9054 5 was be VBD cord-005453-4057qib7 9054 6 approved approve VBN cord-005453-4057qib7 9054 7 in in IN cord-005453-4057qib7 9054 8 11/2017 11/2017 CD cord-005453-4057qib7 9054 9 for for IN cord-005453-4057qib7 9054 10 prophylaxis prophylaxis NN cord-005453-4057qib7 9054 11 ( ( -LRB- cord-005453-4057qib7 9054 12 ppx ppx NNP cord-005453-4057qib7 9054 13 ) ) -RRB- cord-005453-4057qib7 9054 14 in in IN cord-005453-4057qib7 9054 15 CMV CMV NNP cord-005453-4057qib7 9054 16 - - HYPH cord-005453-4057qib7 9054 17 seropositive seropositive JJ cord-005453-4057qib7 9054 18 recipients recipient NNS cord-005453-4057qib7 9054 19 ( ( -LRB- cord-005453-4057qib7 9054 20 R+ R+ NNP cord-005453-4057qib7 9054 21 ) ) -RRB- cord-005453-4057qib7 9054 22 of of IN cord-005453-4057qib7 9054 23 allo allo NN cord-005453-4057qib7 9054 24 - - HYPH cord-005453-4057qib7 9054 25 HCT HCT NNP cord-005453-4057qib7 9054 26 . . . cord-005453-4057qib7 9055 1 Since since IN cord-005453-4057qib7 9055 2 12/2017 12/2017 CD cord-005453-4057qib7 9055 3 , , , cord-005453-4057qib7 9055 4 LTV LTV NNP cord-005453-4057qib7 9055 5 ppx ppx NNP cord-005453-4057qib7 9055 6 was be VBD cord-005453-4057qib7 9055 7 implemented implement VBN cord-005453-4057qib7 9055 8 at at IN cord-005453-4057qib7 9055 9 our -PRON- PRP$ cord-005453-4057qib7 9055 10 center center NN cord-005453-4057qib7 9055 11 for for IN cord-005453-4057qib7 9055 12 both both CC cord-005453-4057qib7 9055 13 primary primary JJ cord-005453-4057qib7 9055 14 and and CC cord-005453-4057qib7 9055 15 secondary secondary JJ cord-005453-4057qib7 9055 16 ppx ppx NN cord-005453-4057qib7 9055 17 . . . cord-005453-4057qib7 9056 1 We -PRON- PRP cord-005453-4057qib7 9056 2 report report VBP cord-005453-4057qib7 9056 3 our -PRON- PRP$ cord-005453-4057qib7 9056 4 real real JJ cord-005453-4057qib7 9056 5 - - HYPH cord-005453-4057qib7 9056 6 world world NN cord-005453-4057qib7 9056 7 experience experience NN cord-005453-4057qib7 9056 8 . . . cord-005453-4057qib7 9057 1 Methods method NNS cord-005453-4057qib7 9057 2 : : : cord-005453-4057qib7 9057 3 Adult adult NN cord-005453-4057qib7 9057 4 CMV CMV NNP cord-005453-4057qib7 9057 5 R+ r+ NN cord-005453-4057qib7 9057 6 allo allo NN cord-005453-4057qib7 9057 7 - - HYPH cord-005453-4057qib7 9057 8 HCT hct NN cord-005453-4057qib7 9057 9 pts pts NN cord-005453-4057qib7 9057 10 who who WP cord-005453-4057qib7 9057 11 initiated initiate VBD cord-005453-4057qib7 9057 12 LTV LTV NNP cord-005453-4057qib7 9057 13 as as IN cord-005453-4057qib7 9057 14 primary primary JJ cord-005453-4057qib7 9057 15 and/or and/or CC cord-005453-4057qib7 9057 16 secondary secondary JJ cord-005453-4057qib7 9057 17 prophylaxis prophylaxis NN cord-005453-4057qib7 9057 18 were be VBD cord-005453-4057qib7 9057 19 identified identify VBN cord-005453-4057qib7 9057 20 between between IN cord-005453-4057qib7 9057 21 1/1/2018 1/1/2018 CD cord-005453-4057qib7 9057 22 and and CC cord-005453-4057qib7 9057 23 6/30/18 6/30/18 CD cord-005453-4057qib7 9057 24 . . . cord-005453-4057qib7 9058 1 Cord cord NN cord-005453-4057qib7 9058 2 blood blood NN cord-005453-4057qib7 9058 3 transplants transplant NNS cord-005453-4057qib7 9058 4 were be VBD cord-005453-4057qib7 9058 5 excluded exclude VBN cord-005453-4057qib7 9058 6 . . . cord-005453-4057qib7 9059 1 The the DT cord-005453-4057qib7 9059 2 primary primary JJ cord-005453-4057qib7 9059 3 outcome outcome NN cord-005453-4057qib7 9059 4 was be VBD cord-005453-4057qib7 9059 5 the the DT cord-005453-4057qib7 9059 6 incidence incidence NN cord-005453-4057qib7 9059 7 of of IN cord-005453-4057qib7 9059 8 clinically clinically RB cord-005453-4057qib7 9059 9 significant significant JJ cord-005453-4057qib7 9059 10 CMV CMV NNP cord-005453-4057qib7 9059 11 infection infection NN cord-005453-4057qib7 9059 12 ( ( -LRB- cord-005453-4057qib7 9059 13 CMV CMV NNP cord-005453-4057qib7 9059 14 viremia viremia NN cord-005453-4057qib7 9059 15 requiring require VBG cord-005453-4057qib7 9059 16 preemptive preemptive JJ cord-005453-4057qib7 9059 17 treatment treatment NN cord-005453-4057qib7 9059 18 or or CC cord-005453-4057qib7 9059 19 CMV CMV NNP cord-005453-4057qib7 9059 20 disease disease NN cord-005453-4057qib7 9059 21 ) ) -RRB- cord-005453-4057qib7 9059 22 . . . cord-005453-4057qib7 9060 1 Pts Pts NNP cord-005453-4057qib7 9060 2 were be VBD cord-005453-4057qib7 9060 3 followed follow VBN cord-005453-4057qib7 9060 4 through through IN cord-005453-4057qib7 9060 5 9/2018 9/2018 CD cord-005453-4057qib7 9060 6 . . . cord-005453-4057qib7 9061 1 Results result NNS cord-005453-4057qib7 9061 2 : : : cord-005453-4057qib7 9062 1 53 53 CD cord-005453-4057qib7 9062 2 pts pt NNS cord-005453-4057qib7 9062 3 initiated initiate VBN cord-005453-4057qib7 9062 4 LTV LTV NNP cord-005453-4057qib7 9062 5 . . . cord-005453-4057qib7 9063 1 69.8 69.8 CD cord-005453-4057qib7 9063 2 % % NN cord-005453-4057qib7 9063 3 pts pt NNS cord-005453-4057qib7 9063 4 were be VBD cord-005453-4057qib7 9063 5 at at IN cord-005453-4057qib7 9063 6 high high JJ cord-005453-4057qib7 9063 7 risk risk NN cord-005453-4057qib7 9063 8 for for IN cord-005453-4057qib7 9063 9 CMV CMV NNP cord-005453-4057qib7 9063 10 reactivation reactivation NN cord-005453-4057qib7 9063 11 and and CC cord-005453-4057qib7 9063 12 disease disease NN cord-005453-4057qib7 9063 13 ( ( -LRB- cord-005453-4057qib7 9063 14 primarily primarily RB cord-005453-4057qib7 9063 15 ex ex AFX cord-005453-4057qib7 9063 16 vivo vivo NN cord-005453-4057qib7 9063 17 T t NN cord-005453-4057qib7 9063 18 - - HYPH cord-005453-4057qib7 9063 19 cell cell NN cord-005453-4057qib7 9063 20 depleted deplete VBN cord-005453-4057qib7 9063 21 HCT HCT NNP cord-005453-4057qib7 9063 22 [ [ -LRB- cord-005453-4057qib7 9063 23 n n NN cord-005453-4057qib7 9063 24 = = SYM cord-005453-4057qib7 9063 25 18 18 CD cord-005453-4057qib7 9063 26 ; ; : cord-005453-4057qib7 9063 27 34 34 CD cord-005453-4057qib7 9063 28 % % NN cord-005453-4057qib7 9063 29 ] ] -RRB- cord-005453-4057qib7 9063 30 or or CC cord-005453-4057qib7 9063 31 haploidentical haploidentical JJ cord-005453-4057qib7 9063 32 T t NN cord-005453-4057qib7 9063 33 - - HYPH cord-005453-4057qib7 9063 34 replete replete JJ cord-005453-4057qib7 9063 35 HCT hct NN cord-005453-4057qib7 9063 36 [ [ -LRB- cord-005453-4057qib7 9063 37 n n NN cord-005453-4057qib7 9063 38 = = SYM cord-005453-4057qib7 9063 39 12 12 CD cord-005453-4057qib7 9063 40 ; ; : cord-005453-4057qib7 9063 41 22.6 22.6 CD cord-005453-4057qib7 9063 42 % % NN cord-005453-4057qib7 9063 43 ] ] -RRB- cord-005453-4057qib7 9063 44 ) ) -RRB- cord-005453-4057qib7 9063 45 . . . cord-005453-4057qib7 9064 1 The the DT cord-005453-4057qib7 9064 2 most most RBS cord-005453-4057qib7 9064 3 common common JJ cord-005453-4057qib7 9064 4 indication indication NN cord-005453-4057qib7 9064 5 for for IN cord-005453-4057qib7 9064 6 HCT HCT NNP cord-005453-4057qib7 9064 7 was be VBD cord-005453-4057qib7 9064 8 acute acute JJ cord-005453-4057qib7 9064 9 myeloid myeloid JJ cord-005453-4057qib7 9064 10 leukemia leukemia NN cord-005453-4057qib7 9065 1 ( ( -LRB- cord-005453-4057qib7 9065 2 n n NN cord-005453-4057qib7 9065 3 = = SYM cord-005453-4057qib7 9065 4 16 16 CD cord-005453-4057qib7 9065 5 ; ; : cord-005453-4057qib7 9065 6 30.1 30.1 CD cord-005453-4057qib7 9065 7 % % NN cord-005453-4057qib7 9065 8 ) ) -RRB- cord-005453-4057qib7 9065 9 and and CC cord-005453-4057qib7 9065 10 the the DT cord-005453-4057qib7 9065 11 majority majority NN cord-005453-4057qib7 9065 12 of of IN cord-005453-4057qib7 9065 13 patients patient NNS cord-005453-4057qib7 9065 14 received receive VBD cord-005453-4057qib7 9065 15 myeloablative myeloablative NNP cord-005453-4057qib7 9065 16 conditioning conditioning NNP cord-005453-4057qib7 9065 17 ( ( -LRB- cord-005453-4057qib7 9065 18 n n NN cord-005453-4057qib7 9065 19 = = SYM cord-005453-4057qib7 9065 20 34 34 CD cord-005453-4057qib7 9065 21 ; ; : cord-005453-4057qib7 9065 22 64.2 64.2 CD cord-005453-4057qib7 9065 23 % % NN cord-005453-4057qib7 9065 24 ) ) -RRB- cord-005453-4057qib7 9065 25 . . . cord-005453-4057qib7 9066 1 39 39 CD cord-005453-4057qib7 9066 2 pts pts NN cord-005453-4057qib7 9066 3 ( ( -LRB- cord-005453-4057qib7 9066 4 73.5 73.5 CD cord-005453-4057qib7 9066 5 % % NN cord-005453-4057qib7 9066 6 ) ) -RRB- cord-005453-4057qib7 9066 7 received receive VBD cord-005453-4057qib7 9066 8 LTV LTV NNP cord-005453-4057qib7 9066 9 as as IN cord-005453-4057qib7 9066 10 primary primary JJ cord-005453-4057qib7 9066 11 ppx ppx NN cord-005453-4057qib7 9066 12 after after IN cord-005453-4057qib7 9066 13 HCT HCT NNP cord-005453-4057qib7 9066 14 , , , cord-005453-4057qib7 9066 15 with with IN cord-005453-4057qib7 9066 16 a a DT cord-005453-4057qib7 9066 17 median median JJ cord-005453-4057qib7 9066 18 day day NN cord-005453-4057qib7 9066 19 of of IN cord-005453-4057qib7 9066 20 LTV LTV NNP cord-005453-4057qib7 9066 21 initiation initiation NN cord-005453-4057qib7 9066 22 of of IN cord-005453-4057qib7 9066 23 D+7 D+7 NNP cord-005453-4057qib7 9066 24 ( ( -LRB- cord-005453-4057qib7 9066 25 range range VBP cord-005453-4057qib7 9066 26 D+7 D+7 NNP cord-005453-4057qib7 9066 27 ─ ─ NNPS cord-005453-4057qib7 9066 28 D+40 D+40 NNP cord-005453-4057qib7 9066 29 ) ) -RRB- cord-005453-4057qib7 9066 30 . . . cord-005453-4057qib7 9067 1 At at IN cord-005453-4057qib7 9067 2 LTV LTV NNP cord-005453-4057qib7 9067 3 initiation initiation NN cord-005453-4057qib7 9067 4 , , , cord-005453-4057qib7 9067 5 34 34 CD cord-005453-4057qib7 9067 6 pts pt NNS cord-005453-4057qib7 9067 7 had have VBD cord-005453-4057qib7 9067 8 an an DT cord-005453-4057qib7 9067 9 undetectable undetectable JJ cord-005453-4057qib7 9067 10 CMV CMV NNP cord-005453-4057qib7 9067 11 DNA dna NN cord-005453-4057qib7 9067 12 , , , cord-005453-4057qib7 9067 13 and and CC cord-005453-4057qib7 9067 14 4 4 CD cord-005453-4057qib7 9067 15 had have VBD cord-005453-4057qib7 9067 16 CMV CMV NNP cord-005453-4057qib7 9067 17 < < XX cord-005453-4057qib7 9068 1 137 137 CD cord-005453-4057qib7 9068 2 IU IU NNP cord-005453-4057qib7 9068 3 / / SYM cord-005453-4057qib7 9068 4 mL. mL. NNS cord-005453-4057qib7 9068 5 Clinically clinically RB cord-005453-4057qib7 9068 6 significant significant JJ cord-005453-4057qib7 9068 7 CMV CMV NNP cord-005453-4057qib7 9068 8 infection infection NN cord-005453-4057qib7 9068 9 requiring require VBG cord-005453-4057qib7 9068 10 preemptive preemptive JJ cord-005453-4057qib7 9068 11 treatment treatment NN cord-005453-4057qib7 9068 12 occurred occur VBD cord-005453-4057qib7 9068 13 in in IN cord-005453-4057qib7 9068 14 2 2 CD cord-005453-4057qib7 9068 15 of of IN cord-005453-4057qib7 9068 16 39 39 CD cord-005453-4057qib7 9068 17 pts pt NNS cord-005453-4057qib7 9068 18 ( ( -LRB- cord-005453-4057qib7 9068 19 5.1 5.1 CD cord-005453-4057qib7 9068 20 % % NN cord-005453-4057qib7 9068 21 ) ) -RRB- cord-005453-4057qib7 9068 22 . . . cord-005453-4057qib7 9069 1 One one CD cord-005453-4057qib7 9069 2 patient patient NN cord-005453-4057qib7 9069 3 was be VBD cord-005453-4057qib7 9069 4 treated treat VBN cord-005453-4057qib7 9069 5 with with IN cord-005453-4057qib7 9069 6 valganciclovir valganciclovir NNP cord-005453-4057qib7 9069 7 ( ( -LRB- cord-005453-4057qib7 9069 8 VGV VGV NNP cord-005453-4057qib7 9069 9 ) ) -RRB- cord-005453-4057qib7 9069 10 for for IN cord-005453-4057qib7 9069 11 persistent persistent JJ cord-005453-4057qib7 9069 12 CMV CMV NNP cord-005453-4057qib7 9069 13 < < XX cord-005453-4057qib7 9069 14 137 137 CD cord-005453-4057qib7 9069 15 IU IU NNP cord-005453-4057qib7 9069 16 / / SYM cord-005453-4057qib7 9069 17 mL ml NN cord-005453-4057qib7 9069 18 and and CC cord-005453-4057qib7 9069 19 received receive VBD cord-005453-4057qib7 9069 20 LTV LTV NNP cord-005453-4057qib7 9069 21 as as IN cord-005453-4057qib7 9069 22 secondary secondary JJ cord-005453-4057qib7 9069 23 ppx ppx NN cord-005453-4057qib7 9069 24 . . . cord-005453-4057qib7 9070 1 A a DT cord-005453-4057qib7 9070 2 2nd 2nd JJ cord-005453-4057qib7 9070 3 patient patient NN cord-005453-4057qib7 9070 4 developed develop VBD cord-005453-4057qib7 9070 5 persistently persistently RB cord-005453-4057qib7 9070 6 detectable detectable JJ cord-005453-4057qib7 9070 7 CMV CMV NNP cord-005453-4057qib7 9070 8 ( ( -LRB- cord-005453-4057qib7 9070 9 < < XX cord-005453-4057qib7 9070 10 137 137 CD cord-005453-4057qib7 9070 11 IU/ iu/ CD cord-005453-4057qib7 9070 12 mL ml NN cord-005453-4057qib7 9070 13 ) ) -RRB- cord-005453-4057qib7 9070 14 and and CC cord-005453-4057qib7 9070 15 breakthrough breakthrough VB cord-005453-4057qib7 9070 16 CMV CMV NNP cord-005453-4057qib7 9070 17 viremia viremia NN cord-005453-4057qib7 9070 18 with with IN cord-005453-4057qib7 9070 19 a a DT cord-005453-4057qib7 9070 20 mutation mutation NN cord-005453-4057qib7 9070 21 in in IN cord-005453-4057qib7 9070 22 UL56 UL56 NNP cord-005453-4057qib7 9070 23 at at IN cord-005453-4057qib7 9070 24 site site NN cord-005453-4057qib7 9070 25 C325YLTV C325YLTV NNP cord-005453-4057qib7 9070 26 successfully successfully RB cord-005453-4057qib7 9070 27 treated treat VBN cord-005453-4057qib7 9070 28 with with IN cord-005453-4057qib7 9070 29 VGV VGV NNP cord-005453-4057qib7 9070 30 . . . cord-005453-4057qib7 9071 1 The the DT cord-005453-4057qib7 9071 2 median median JJ cord-005453-4057qib7 9071 3 duration duration NN cord-005453-4057qib7 9071 4 of of IN cord-005453-4057qib7 9071 5 primary primary JJ cord-005453-4057qib7 9071 6 LTV LTV NNP cord-005453-4057qib7 9071 7 ppx ppx NNP cord-005453-4057qib7 9071 8 was be VBD cord-005453-4057qib7 9071 9 116 116 CD cord-005453-4057qib7 9071 10 days day NNS cord-005453-4057qib7 9071 11 ( ( -LRB- cord-005453-4057qib7 9071 12 54 54 CD cord-005453-4057qib7 9071 13 - - SYM cord-005453-4057qib7 9071 14 221 221 CD cord-005453-4057qib7 9071 15 ) ) -RRB- cord-005453-4057qib7 9071 16 , , , cord-005453-4057qib7 9071 17 with with IN cord-005453-4057qib7 9071 18 primary primary JJ cord-005453-4057qib7 9071 19 ppx ppx NN cord-005453-4057qib7 9071 20 continuing continue VBG cord-005453-4057qib7 9071 21 beyond beyond IN cord-005453-4057qib7 9071 22 14 14 CD cord-005453-4057qib7 9071 23 weeks week NNS cord-005453-4057qib7 9071 24 post post NN cord-005453-4057qib7 9071 25 HCT hct NN cord-005453-4057qib7 9071 26 in in IN cord-005453-4057qib7 9071 27 29 29 CD cord-005453-4057qib7 9071 28 pts pt NNS cord-005453-4057qib7 9071 29 . . . cord-005453-4057qib7 9072 1 The the DT cord-005453-4057qib7 9072 2 median median JJ cord-005453-4057qib7 9072 3 additional additional JJ cord-005453-4057qib7 9072 4 follow follow NN cord-005453-4057qib7 9072 5 - - HYPH cord-005453-4057qib7 9072 6 up up NN cord-005453-4057qib7 9072 7 in in IN cord-005453-4057qib7 9072 8 patients patient NNS cord-005453-4057qib7 9072 9 who who WP cord-005453-4057qib7 9072 10 discontinued discontinue VBD cord-005453-4057qib7 9072 11 LTV LTV NNP cord-005453-4057qib7 9072 12 was be VBD cord-005453-4057qib7 9072 13 40 40 CD cord-005453-4057qib7 9072 14 days day NNS cord-005453-4057qib7 9072 15 ( ( -LRB- cord-005453-4057qib7 9072 16 0 0 CD cord-005453-4057qib7 9072 17 - - SYM cord-005453-4057qib7 9072 18 154 154 CD cord-005453-4057qib7 9072 19 ) ) -RRB- cord-005453-4057qib7 9072 20 , , , cord-005453-4057qib7 9072 21 without without IN cord-005453-4057qib7 9072 22 clinically clinically RB cord-005453-4057qib7 9072 23 significant significant JJ cord-005453-4057qib7 9072 24 CMV CMV NNP cord-005453-4057qib7 9072 25 infection infection NN cord-005453-4057qib7 9072 26 to to IN cord-005453-4057qib7 9072 27 date date NN cord-005453-4057qib7 9072 28 . . . cord-005453-4057qib7 9073 1 An an DT cord-005453-4057qib7 9073 2 additional additional JJ cord-005453-4057qib7 9073 3 14pts 14pts NN cord-005453-4057qib7 9073 4 ( ( -LRB- cord-005453-4057qib7 9073 5 15 15 CD cord-005453-4057qib7 9073 6 pts pts NN cord-005453-4057qib7 9073 7 overall overall JJ cord-005453-4057qib7 9073 8 ; ; : cord-005453-4057qib7 9073 9 28.3 28.3 CD cord-005453-4057qib7 9073 10 % % NN cord-005453-4057qib7 9073 11 ) ) -RRB- cord-005453-4057qib7 9073 12 received receive VBD cord-005453-4057qib7 9073 13 LTV LTV NNP cord-005453-4057qib7 9073 14 as as IN cord-005453-4057qib7 9073 15 secondary secondary JJ cord-005453-4057qib7 9073 16 ppx ppx NN cord-005453-4057qib7 9073 17 after after IN cord-005453-4057qib7 9073 18 CMV CMV NNP cord-005453-4057qib7 9073 19 pre pre VBD cord-005453-4057qib7 9073 20 - - JJ cord-005453-4057qib7 9073 21 emptive emptive JJ cord-005453-4057qib7 9073 22 therapy therapy NN cord-005453-4057qib7 9073 23 . . . cord-005453-4057qib7 9074 1 The the DT cord-005453-4057qib7 9074 2 median median JJ cord-005453-4057qib7 9074 3 duration duration NN cord-005453-4057qib7 9074 4 of of IN cord-005453-4057qib7 9074 5 secondary secondary JJ cord-005453-4057qib7 9074 6 LTV LTV NNP cord-005453-4057qib7 9074 7 ppx ppx NNP cord-005453-4057qib7 9074 8 was be VBD cord-005453-4057qib7 9074 9 127 127 CD cord-005453-4057qib7 9074 10 days day NNS cord-005453-4057qib7 9074 11 ( ( -LRB- cord-005453-4057qib7 9074 12 18 18 CD cord-005453-4057qib7 9074 13 - - SYM cord-005453-4057qib7 9074 14 270 270 CD cord-005453-4057qib7 9074 15 ) ) -RRB- cord-005453-4057qib7 9074 16 , , , cord-005453-4057qib7 9074 17 with with IN cord-005453-4057qib7 9074 18 no no DT cord-005453-4057qib7 9074 19 reactivation reactivation NN cord-005453-4057qib7 9074 20 . . . cord-005453-4057qib7 9075 1 LTV LTV NNP cord-005453-4057qib7 9075 2 was be VBD cord-005453-4057qib7 9075 3 not not RB cord-005453-4057qib7 9075 4 discontinued discontinue VBN cord-005453-4057qib7 9075 5 due due IN cord-005453-4057qib7 9075 6 to to IN cord-005453-4057qib7 9075 7 toxicity toxicity NN cord-005453-4057qib7 9075 8 or or CC cord-005453-4057qib7 9075 9 intolerance intolerance NN cord-005453-4057qib7 9075 10 in in IN cord-005453-4057qib7 9075 11 any any DT cord-005453-4057qib7 9075 12 patient patient NN cord-005453-4057qib7 9075 13 . . . cord-005453-4057qib7 9076 1 CMV CMV NNP cord-005453-4057qib7 9076 2 outcomes outcome NNS cord-005453-4057qib7 9076 3 are be VBP cord-005453-4057qib7 9076 4 summarized summarize VBN cord-005453-4057qib7 9076 5 in in IN cord-005453-4057qib7 9076 6 figure figure NN cord-005453-4057qib7 9076 7 1 1 CD cord-005453-4057qib7 9076 8 . . . cord-005453-4057qib7 9077 1 All all DT cord-005453-4057qib7 9077 2 - - HYPH cord-005453-4057qib7 9077 3 cause cause NN cord-005453-4057qib7 9077 4 mortality mortality NN cord-005453-4057qib7 9077 5 for for IN cord-005453-4057qib7 9077 6 the the DT cord-005453-4057qib7 9077 7 53 53 CD cord-005453-4057qib7 9077 8 pts pt NNS cord-005453-4057qib7 9077 9 over over IN cord-005453-4057qib7 9077 10 the the DT cord-005453-4057qib7 9077 11 observational observational JJ cord-005453-4057qib7 9077 12 period period NN cord-005453-4057qib7 9077 13 was be VBD cord-005453-4057qib7 9077 14 11.3 11.3 CD cord-005453-4057qib7 9077 15 % % NN cord-005453-4057qib7 9077 16 . . . cord-005453-4057qib7 9078 1 Conclusions conclusion NNS cord-005453-4057qib7 9078 2 : : : cord-005453-4057qib7 9079 1 Primary primary JJ cord-005453-4057qib7 9079 2 LTV LTV NNP cord-005453-4057qib7 9079 3 ppx ppx NN cord-005453-4057qib7 9079 4 significantly significantly RB cord-005453-4057qib7 9079 5 reduced reduce VBD cord-005453-4057qib7 9079 6 CMV CMV NNP cord-005453-4057qib7 9079 7 reactivation reactivation NN cord-005453-4057qib7 9079 8 , , , cord-005453-4057qib7 9079 9 and and CC cord-005453-4057qib7 9079 10 high high JJ cord-005453-4057qib7 9079 11 - - HYPH cord-005453-4057qib7 9079 12 risk risk NN cord-005453-4057qib7 9079 13 patients patient NNS cord-005453-4057qib7 9079 14 may may MD cord-005453-4057qib7 9079 15 benefit benefit VB cord-005453-4057qib7 9079 16 from from IN cord-005453-4057qib7 9079 17 extended extended JJ cord-005453-4057qib7 9079 18 prophylaxis prophylaxis NN cord-005453-4057qib7 9079 19 . . . cord-005453-4057qib7 9080 1 In in IN cord-005453-4057qib7 9080 2 patients patient NNS cord-005453-4057qib7 9080 3 who who WP cord-005453-4057qib7 9080 4 received receive VBD cord-005453-4057qib7 9080 5 preemptive preemptive JJ cord-005453-4057qib7 9080 6 therapy therapy NN cord-005453-4057qib7 9080 7 for for IN cord-005453-4057qib7 9080 8 CMV CMV NNP cord-005453-4057qib7 9080 9 , , , cord-005453-4057qib7 9080 10 use use NN cord-005453-4057qib7 9080 11 of of IN cord-005453-4057qib7 9080 12 secondary secondary JJ cord-005453-4057qib7 9080 13 ppx ppx NN cord-005453-4057qib7 9080 14 showed show VBD cord-005453-4057qib7 9080 15 no no DT cord-005453-4057qib7 9080 16 recurrent recurrent JJ cord-005453-4057qib7 9080 17 CMV CMV NNP cord-005453-4057qib7 9080 18 reactivation reactivation NN cord-005453-4057qib7 9080 19 . . . cord-005453-4057qib7 9081 1 LTV LTV NNP cord-005453-4057qib7 9081 2 is be VBZ cord-005453-4057qib7 9081 3 well well RB cord-005453-4057qib7 9081 4 tolerated tolerate VBN cord-005453-4057qib7 9081 5 . . . cord-005453-4057qib7 9082 1 Additional additional JJ cord-005453-4057qib7 9082 2 studies study NNS cord-005453-4057qib7 9082 3 are be VBP cord-005453-4057qib7 9082 4 needed need VBN cord-005453-4057qib7 9082 5 to to TO cord-005453-4057qib7 9082 6 determine determine VB cord-005453-4057qib7 9082 7 optimal optimal JJ cord-005453-4057qib7 9082 8 ppx ppx NN cord-005453-4057qib7 9082 9 duration duration NN cord-005453-4057qib7 9082 10 and and CC cord-005453-4057qib7 9082 11 to to TO cord-005453-4057qib7 9082 12 clarify clarify VB cord-005453-4057qib7 9082 13 role role NN cord-005453-4057qib7 9082 14 of of IN cord-005453-4057qib7 9082 15 secondary secondary JJ cord-005453-4057qib7 9082 16 CMV CMV NNP cord-005453-4057qib7 9082 17 ppx ppx NN cord-005453-4057qib7 9082 18 in in IN cord-005453-4057qib7 9082 19 high high JJ cord-005453-4057qib7 9082 20 - - HYPH cord-005453-4057qib7 9082 21 risk risk NN cord-005453-4057qib7 9082 22 allo allo NN cord-005453-4057qib7 9082 23 - - HYPH cord-005453-4057qib7 9082 24 HCT hct NN cord-005453-4057qib7 9082 25 . . . cord-005453-4057qib7 9083 1 The the DT cord-005453-4057qib7 9083 2 future future JJ cord-005453-4057qib7 9083 3 standard standard NN cord-005453-4057qib7 9083 4 of of IN cord-005453-4057qib7 9083 5 care care NN cord-005453-4057qib7 9083 6 will will MD cord-005453-4057qib7 9083 7 likely likely RB cord-005453-4057qib7 9083 8 include include VB cord-005453-4057qib7 9083 9 extended extend VBN cord-005453-4057qib7 9083 10 primary primary JJ cord-005453-4057qib7 9083 11 ppx ppx NN cord-005453-4057qib7 9083 12 and and CC cord-005453-4057qib7 9083 13 secondary secondary JJ cord-005453-4057qib7 9083 14 ppx ppx NN cord-005453-4057qib7 9083 15 and and CC cord-005453-4057qib7 9083 16 result result VB cord-005453-4057qib7 9083 17 in in IN cord-005453-4057qib7 9083 18 decreased decreased JJ cord-005453-4057qib7 9083 19 morbidity morbidity NN cord-005453-4057qib7 9083 20 and and CC cord-005453-4057qib7 9083 21 mortality mortality NN cord-005453-4057qib7 9083 22 associated associate VBN cord-005453-4057qib7 9083 23 with with IN cord-005453-4057qib7 9083 24 CMV CMV NNP cord-005453-4057qib7 9083 25 . . . cord-005453-4057qib7 9084 1 Disclosure disclosure NN cord-005453-4057qib7 9084 2 : : : cord-005453-4057qib7 9085 1 Andrew Andrew NNP cord-005453-4057qib7 9085 2 Lin Lin NNP cord-005453-4057qib7 9085 3 -Nothing -Nothing . cord-005453-4057qib7 9086 1 to to TO cord-005453-4057qib7 9086 2 declare declare VB cord-005453-4057qib7 9086 3 , , , cord-005453-4057qib7 9086 4 Molly Molly NNP cord-005453-4057qib7 9086 5 A. A. NNP cord-005453-4057qib7 9086 6 Maloy Maloy NNP cord-005453-4057qib7 9086 7 -Nothing -nothing NN cord-005453-4057qib7 9086 8 to to TO cord-005453-4057qib7 9086 9 declare declare VB cord-005453-4057qib7 9086 10 , , , cord-005453-4057qib7 9086 11 Valkal Valkal NNP cord-005453-4057qib7 9086 12 Bhatt Bhatt NNP cord-005453-4057qib7 9086 13 -Nothing -nothe VBG cord-005453-4057qib7 9086 14 to to TO cord-005453-4057qib7 9086 15 declare declare VB cord-005453-4057qib7 9086 16 , , , cord-005453-4057qib7 9086 17 Lauren Lauren NNP cord-005453-4057qib7 9086 18 DeRespiris DeRespiris NNP cord-005453-4057qib7 9086 19 -Nothing -nothe VBG cord-005453-4057qib7 9086 20 to to TO cord-005453-4057qib7 9086 21 declare declare VB cord-005453-4057qib7 9086 22 , , , cord-005453-4057qib7 9086 23 Meagan Meagan NNP cord-005453-4057qib7 9086 24 Griffin Griffin NNP cord-005453-4057qib7 9086 25 -Nothing -nothe VBG cord-005453-4057qib7 9086 26 to to TO cord-005453-4057qib7 9086 27 declare declare VB cord-005453-4057qib7 9086 28 Carmen Carmen NNP cord-005453-4057qib7 9086 29 Lau Lau NNP cord-005453-4057qib7 9086 30 -Nothing -nothe VBG cord-005453-4057qib7 9086 31 to to TO cord-005453-4057qib7 9086 32 declare declare VB cord-005453-4057qib7 9086 33 , , , cord-005453-4057qib7 9086 34 Anthony Anthony NNP cord-005453-4057qib7 9086 35 J. J. NNP cord-005453-4057qib7 9086 36 Proli Proli NNP cord-005453-4057qib7 9086 37 -Nothing -nothe VBG cord-005453-4057qib7 9087 1 to to TO cord-005453-4057qib7 9087 2 declare declare VB cord-005453-4057qib7 9087 3 , , , cord-005453-4057qib7 9087 4 Juliet Juliet NNP cord-005453-4057qib7 9087 5 Barker Barker NNP cord-005453-4057qib7 9087 6 -Angiocrine -Angiocrine NNP cord-005453-4057qib7 9087 7 Bioscience Bioscience NNP cord-005453-4057qib7 9087 8 , , , cord-005453-4057qib7 9087 9 letermovir letermovir JJ cord-005453-4057qib7 9087 10 primary primary JJ cord-005453-4057qib7 9087 11 prophylaxis prophylaxis NN cord-005453-4057qib7 9087 12 ( ( -LRB- cord-005453-4057qib7 9087 13 PP PP NNP cord-005453-4057qib7 9087 14 ) ) -RRB- cord-005453-4057qib7 9087 15 has have VBZ cord-005453-4057qib7 9087 16 been be VBN cord-005453-4057qib7 9087 17 shown show VBN cord-005453-4057qib7 9087 18 to to TO cord-005453-4057qib7 9087 19 reduce reduce VB cord-005453-4057qib7 9087 20 clinically clinically RB cord-005453-4057qib7 9087 21 significant significant JJ cord-005453-4057qib7 9087 22 CMV CMV NNP cord-005453-4057qib7 9087 23 infection infection NN cord-005453-4057qib7 9087 24 with with IN cord-005453-4057qib7 9087 25 a a DT cord-005453-4057qib7 9087 26 favorable favorable JJ cord-005453-4057qib7 9087 27 safety safety NN cord-005453-4057qib7 9087 28 profile profile NN cord-005453-4057qib7 9087 29 . . . cord-005453-4057qib7 9088 1 Letermovir Letermovir NNP cord-005453-4057qib7 9088 2 PP PP NNP cord-005453-4057qib7 9088 3 will will MD cord-005453-4057qib7 9088 4 improve improve VB cord-005453-4057qib7 9088 5 the the DT cord-005453-4057qib7 9088 6 outcome outcome NN cord-005453-4057qib7 9088 7 of of IN cord-005453-4057qib7 9088 8 seropositive seropositive JJ cord-005453-4057qib7 9088 9 patients patient NNS cord-005453-4057qib7 9088 10 . . . cord-005453-4057qib7 9089 1 However however RB cord-005453-4057qib7 9089 2 , , , cord-005453-4057qib7 9089 3 patients patient NNS cord-005453-4057qib7 9089 4 who who WP cord-005453-4057qib7 9089 5 did do VBD cord-005453-4057qib7 9089 6 not not RB cord-005453-4057qib7 9089 7 benefit benefit VB cord-005453-4057qib7 9089 8 from from IN cord-005453-4057qib7 9089 9 PP PP NNP cord-005453-4057qib7 9089 10 and and CC cord-005453-4057qib7 9089 11 experienced experience VBD cord-005453-4057qib7 9089 12 > > XX cord-005453-4057qib7 9089 13 1 1 CD cord-005453-4057qib7 9089 14 CMV CMV NNP cord-005453-4057qib7 9089 15 episode episode NN cord-005453-4057qib7 9089 16 ( ( -LRB- cord-005453-4057qib7 9089 17 infection infection NN cord-005453-4057qib7 9089 18 or or CC cord-005453-4057qib7 9089 19 disease disease NN cord-005453-4057qib7 9089 20 ) ) -RRB- cord-005453-4057qib7 9089 21 after after IN cord-005453-4057qib7 9089 22 HCT HCT NNP cord-005453-4057qib7 9089 23 may may MD cord-005453-4057qib7 9089 24 be be VB cord-005453-4057qib7 9089 25 candidate candidate NN cord-005453-4057qib7 9089 26 to to IN cord-005453-4057qib7 9089 27 secondary secondary JJ cord-005453-4057qib7 9089 28 prophylaxis prophylaxis NN cord-005453-4057qib7 9089 29 ( ( -LRB- cord-005453-4057qib7 9089 30 SP SP NNP cord-005453-4057qib7 9089 31 ) ) -RRB- cord-005453-4057qib7 9089 32 . . . cord-005453-4057qib7 9090 1 Indeed indeed RB cord-005453-4057qib7 9090 2 half half NN cord-005453-4057qib7 9090 3 of of IN cord-005453-4057qib7 9090 4 them -PRON- PRP cord-005453-4057qib7 9090 5 will will MD cord-005453-4057qib7 9090 6 have have VB cord-005453-4057qib7 9090 7 > > $ cord-005453-4057qib7 9090 8 1 1 CD cord-005453-4057qib7 9090 9 recurrent recurrent JJ cord-005453-4057qib7 9090 10 episode episode NN cord-005453-4057qib7 9090 11 after after IN cord-005453-4057qib7 9090 12 pre pre JJ cord-005453-4057qib7 9090 13 - - JJ cord-005453-4057qib7 9090 14 emptive emptive JJ cord-005453-4057qib7 9090 15 treatment treatment NN cord-005453-4057qib7 9090 16 ( ( -LRB- cord-005453-4057qib7 9090 17 PET PET NNP cord-005453-4057qib7 9090 18 ) ) -RRB- cord-005453-4057qib7 9090 19 . . . cord-005453-4057qib7 9091 1 Letermovir Letermovir NNP cord-005453-4057qib7 9091 2 is be VBZ cord-005453-4057qib7 9091 3 available available JJ cord-005453-4057qib7 9091 4 since since IN cord-005453-4057qib7 9091 5 November November NNP cord-005453-4057qib7 9091 6 2017 2017 CD cord-005453-4057qib7 9091 7 as as IN cord-005453-4057qib7 9091 8 part part NN cord-005453-4057qib7 9091 9 of of IN cord-005453-4057qib7 9091 10 the the DT cord-005453-4057qib7 9091 11 French french JJ cord-005453-4057qib7 9091 12 early early JJ cord-005453-4057qib7 9091 13 access access NN cord-005453-4057qib7 9091 14 program program NN cord-005453-4057qib7 9091 15 for for IN cord-005453-4057qib7 9091 16 PP PP NNP cord-005453-4057qib7 9091 17 and and CC cord-005453-4057qib7 9091 18 SP SP NNP cord-005453-4057qib7 9091 19 . . . cord-005453-4057qib7 9092 1 We -PRON- PRP cord-005453-4057qib7 9092 2 report report VBP cord-005453-4057qib7 9092 3 the the DT cord-005453-4057qib7 9092 4 outcome outcome NN cord-005453-4057qib7 9092 5 of of IN cord-005453-4057qib7 9092 6 patients patient NNS cord-005453-4057qib7 9092 7 who who WP cord-005453-4057qib7 9092 8 benefited benefit VBD cord-005453-4057qib7 9092 9 from from IN cord-005453-4057qib7 9092 10 letermovir letermovir NNS cord-005453-4057qib7 9092 11 SP SP NNP cord-005453-4057qib7 9092 12 in in IN cord-005453-4057qib7 9092 13 the the DT cord-005453-4057qib7 9092 14 context context NN cord-005453-4057qib7 9092 15 of of IN cord-005453-4057qib7 9092 16 this this DT cord-005453-4057qib7 9092 17 program program NN cord-005453-4057qib7 9092 18 . . . cord-005453-4057qib7 9093 1 Methods method NNS cord-005453-4057qib7 9093 2 : : : cord-005453-4057qib7 9093 3 Letermovir Letermovir NNP cord-005453-4057qib7 9093 4 is be VBZ cord-005453-4057qib7 9093 5 granted grant VBN cord-005453-4057qib7 9093 6 , , , cord-005453-4057qib7 9093 7 in in IN cord-005453-4057qib7 9093 8 a a DT cord-005453-4057qib7 9093 9 restrictive restrictive JJ cord-005453-4057qib7 9093 10 manner manner NN cord-005453-4057qib7 9093 11 , , , cord-005453-4057qib7 9093 12 by by IN cord-005453-4057qib7 9093 13 the the DT cord-005453-4057qib7 9093 14 French french JJ cord-005453-4057qib7 9093 15 drug drug NN cord-005453-4057qib7 9093 16 agency agency NN cord-005453-4057qib7 9093 17 ( ( -LRB- cord-005453-4057qib7 9093 18 ANSM ANSM NNP cord-005453-4057qib7 9093 19 ) ) -RRB- cord-005453-4057qib7 9093 20 on on IN cord-005453-4057qib7 9093 21 a a DT cord-005453-4057qib7 9093 22 case case NN cord-005453-4057qib7 9093 23 - - HYPH cord-005453-4057qib7 9093 24 by by IN cord-005453-4057qib7 9093 25 - - HYPH cord-005453-4057qib7 9093 26 case case NN cord-005453-4057qib7 9093 27 basis basis NN cord-005453-4057qib7 9093 28 for for IN cord-005453-4057qib7 9093 29 prophylaxis prophylaxis NN cord-005453-4057qib7 9093 30 of of IN cord-005453-4057qib7 9093 31 CMV CMV NNP cord-005453-4057qib7 9093 32 episode episode NN cord-005453-4057qib7 9093 33 , , , cord-005453-4057qib7 9093 34 in in IN cord-005453-4057qib7 9093 35 CMV CMV NNP cord-005453-4057qib7 9093 36 - - HYPH cord-005453-4057qib7 9093 37 seropositive seropositive JJ cord-005453-4057qib7 9093 38 adult adult NN cord-005453-4057qib7 9093 39 allogeneic allogeneic NN cord-005453-4057qib7 9093 40 HCT HCT NNP cord-005453-4057qib7 9093 41 recipients recipient NNS cord-005453-4057qib7 9093 42 . . . cord-005453-4057qib7 9094 1 SP SP NNP cord-005453-4057qib7 9094 2 patients patient NNS cord-005453-4057qib7 9094 3 should should MD cord-005453-4057qib7 9094 4 have have VB cord-005453-4057qib7 9094 5 a a DT cord-005453-4057qib7 9094 6 negative negative JJ cord-005453-4057qib7 9094 7 baseline baseline JJ cord-005453-4057qib7 9094 8 CMV CMV NNP cord-005453-4057qib7 9094 9 PCR PCR NNP cord-005453-4057qib7 9094 10 , , , cord-005453-4057qib7 9094 11 have have VBP cord-005453-4057qib7 9094 12 already already RB cord-005453-4057qib7 9094 13 experienced experience VBN cord-005453-4057qib7 9094 14 > > XX cord-005453-4057qib7 9094 15 1 1 CD cord-005453-4057qib7 9094 16 CMV CMV NNP cord-005453-4057qib7 9094 17 episode episode NN cord-005453-4057qib7 9094 18 , , , cord-005453-4057qib7 9094 19 in in IN cord-005453-4057qib7 9094 20 the the DT cord-005453-4057qib7 9094 21 context context NN cord-005453-4057qib7 9094 22 of of IN cord-005453-4057qib7 9094 23 a a DT cord-005453-4057qib7 9094 24 potentially potentially RB cord-005453-4057qib7 9094 25 harmful harmful JJ cord-005453-4057qib7 9094 26 PET pet NN cord-005453-4057qib7 9094 27 according accord VBG cord-005453-4057qib7 9094 28 to to IN cord-005453-4057qib7 9094 29 physicians physician NNS cord-005453-4057qib7 9094 30 . . . cord-005453-4057qib7 9095 1 Planned plan VBN cord-005453-4057qib7 9095 2 letermovir letermovir NNP cord-005453-4057qib7 9095 3 daily daily RB cord-005453-4057qib7 9095 4 dose dose NN cord-005453-4057qib7 9095 5 was be VBD cord-005453-4057qib7 9095 6 240 240 CD cord-005453-4057qib7 9095 7 mg mg NN cord-005453-4057qib7 9095 8 in in IN cord-005453-4057qib7 9095 9 case case NN cord-005453-4057qib7 9095 10 of of IN cord-005453-4057qib7 9095 11 concomitant concomitant JJ cord-005453-4057qib7 9095 12 cyclosporine cyclosporine NN cord-005453-4057qib7 9095 13 and and CC cord-005453-4057qib7 9095 14 480 480 CD cord-005453-4057qib7 9095 15 mg mg NNS cord-005453-4057qib7 9095 16 otherwise otherwise RB cord-005453-4057qib7 9095 17 . . . cord-005453-4057qib7 9096 1 All all DT cord-005453-4057qib7 9096 2 patients patient NNS cord-005453-4057qib7 9096 3 were be VBD cord-005453-4057qib7 9096 4 routinely routinely RB cord-005453-4057qib7 9096 5 screened screen VBN cord-005453-4057qib7 9096 6 by by IN cord-005453-4057qib7 9096 7 blood blood NN cord-005453-4057qib7 9096 8 or or CC cord-005453-4057qib7 9096 9 plasma plasma NN cord-005453-4057qib7 9096 10 CMV CMV NNP cord-005453-4057qib7 9096 11 PCR PCR NNP cord-005453-4057qib7 9096 12 . . . cord-005453-4057qib7 9097 1 Results result NNS cord-005453-4057qib7 9097 2 : : : cord-005453-4057qib7 9098 1 Between between IN cord-005453-4057qib7 9098 2 November November NNP cord-005453-4057qib7 9098 3 2017-July 2017-july CD cord-005453-4057qib7 9098 4 2018 2018 CD cord-005453-4057qib7 9098 5 , , , cord-005453-4057qib7 9098 6 57 57 CD cord-005453-4057qib7 9098 7 patients patient NNS cord-005453-4057qib7 9098 8 received receive VBD cord-005453-4057qib7 9098 9 letermovir letermovir NNS cord-005453-4057qib7 9098 10 in in IN cord-005453-4057qib7 9098 11 the the DT cord-005453-4057qib7 9098 12 early early JJ cord-005453-4057qib7 9098 13 access access NN cord-005453-4057qib7 9098 14 program program NN cord-005453-4057qib7 9098 15 , , , cord-005453-4057qib7 9098 16 22 22 CD cord-005453-4057qib7 9098 17 for for IN cord-005453-4057qib7 9098 18 PP PP NNP cord-005453-4057qib7 9098 19 , , , cord-005453-4057qib7 9098 20 and and CC cord-005453-4057qib7 9098 21 35 35 CD cord-005453-4057qib7 9098 22 for for IN cord-005453-4057qib7 9098 23 SP SP NNP cord-005453-4057qib7 9098 24 . . . cord-005453-4057qib7 9099 1 Among among IN cord-005453-4057qib7 9099 2 the the DT cord-005453-4057qib7 9099 3 35 35 CD cord-005453-4057qib7 9099 4 SP SP NNP cord-005453-4057qib7 9099 5 patients patient NNS cord-005453-4057qib7 9099 6 , , , cord-005453-4057qib7 9099 7 6 6 CD cord-005453-4057qib7 9099 8 had have VBD cord-005453-4057qib7 9099 9 previous previous JJ cord-005453-4057qib7 9099 10 CMV CMV NNP cord-005453-4057qib7 9099 11 disease disease NN cord-005453-4057qib7 9099 12 ( ( -LRB- cord-005453-4057qib7 9099 13 gut gut NN cord-005453-4057qib7 9099 14 : : : cord-005453-4057qib7 9099 15 5 5 CD cord-005453-4057qib7 9099 16 ; ; : cord-005453-4057qib7 9099 17 CNS CNS NNP cord-005453-4057qib7 9099 18 : : : cord-005453-4057qib7 9099 19 1 1 CD cord-005453-4057qib7 9099 20 ) ) -RRB- cord-005453-4057qib7 9099 21 . . . cord-005453-4057qib7 9100 1 Mean mean JJ cord-005453-4057qib7 9100 2 age age NN cord-005453-4057qib7 9100 3 was be VBD cord-005453-4057qib7 9100 4 55±13 55±13 CD cord-005453-4057qib7 9100 5 years year NNS cord-005453-4057qib7 9100 6 , , , cord-005453-4057qib7 9100 7 M M NNP cord-005453-4057qib7 9100 8 / / SYM cord-005453-4057qib7 9100 9 F F NNP cord-005453-4057qib7 9100 10 ratio ratio NN cord-005453-4057qib7 9100 11 was be VBD cord-005453-4057qib7 9100 12 22/13 22/13 CD cord-005453-4057qib7 9100 13 . . . cord-005453-4057qib7 9101 1 The the DT cord-005453-4057qib7 9101 2 SP SP NNP cord-005453-4057qib7 9101 3 cohort cohort NN cord-005453-4057qib7 9101 4 included include VBD cord-005453-4057qib7 9101 5 one one CD cord-005453-4057qib7 9101 6 cord cord NN cord-005453-4057qib7 9101 7 blood blood NN cord-005453-4057qib7 9101 8 and and CC cord-005453-4057qib7 9101 9 10 10 CD cord-005453-4057qib7 9101 10 haplo haplo NN cord-005453-4057qib7 9101 11 - - HYPH cord-005453-4057qib7 9101 12 identical identical JJ cord-005453-4057qib7 9101 13 HCT hct NN cord-005453-4057qib7 9101 14 . . . cord-005453-4057qib7 9102 1 Main main JJ cord-005453-4057qib7 9102 2 diagnoses diagnosis NNS cord-005453-4057qib7 9102 3 were be VBD cord-005453-4057qib7 9102 4 acute acute JJ cord-005453-4057qib7 9102 5 leukemia leukemia NN cord-005453-4057qib7 9102 6 ( ( -LRB- cord-005453-4057qib7 9102 7 46 46 CD cord-005453-4057qib7 9102 8 % % NN cord-005453-4057qib7 9102 9 ) ) -RRB- cord-005453-4057qib7 9102 10 and and CC cord-005453-4057qib7 9102 11 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 9102 12 syndrome syndrome NN cord-005453-4057qib7 9102 13 ( ( -LRB- cord-005453-4057qib7 9102 14 26 26 CD cord-005453-4057qib7 9102 15 % % NN cord-005453-4057qib7 9102 16 ) ) -RRB- cord-005453-4057qib7 9102 17 . . . cord-005453-4057qib7 9103 1 The the DT cord-005453-4057qib7 9103 2 conditioning conditioning NN cord-005453-4057qib7 9103 3 regimen regimen NN cord-005453-4057qib7 9103 4 was be VBD cord-005453-4057qib7 9103 5 myeloablative myeloablative JJ cord-005453-4057qib7 9103 6 in in IN cord-005453-4057qib7 9103 7 47 47 CD cord-005453-4057qib7 9103 8 % % NN cord-005453-4057qib7 9103 9 and and CC cord-005453-4057qib7 9103 10 included include VBD cord-005453-4057qib7 9103 11 ATG ATG NNP cord-005453-4057qib7 9103 12 in in IN cord-005453-4057qib7 9103 13 61 61 CD cord-005453-4057qib7 9103 14 % % NN cord-005453-4057qib7 9103 15 . . . cord-005453-4057qib7 9104 1 Based base VBN cord-005453-4057qib7 9104 2 on on IN cord-005453-4057qib7 9104 3 available available JJ cord-005453-4057qib7 9104 4 data datum NNS cord-005453-4057qib7 9104 5 ( ( -LRB- cord-005453-4057qib7 9104 6 6 6 CD cord-005453-4057qib7 9104 7 missing miss VBG cord-005453-4057qib7 9104 8 data datum NNS cord-005453-4057qib7 9104 9 , , , cord-005453-4057qib7 9104 10 md md NNP cord-005453-4057qib7 9104 11 ) ) -RRB- cord-005453-4057qib7 9104 12 , , , cord-005453-4057qib7 9104 13 previous previous JJ cord-005453-4057qib7 9104 14 GvHD GvHD NNP cord-005453-4057qib7 9104 15 was be VBD cord-005453-4057qib7 9104 16 present present JJ cord-005453-4057qib7 9104 17 in in IN cord-005453-4057qib7 9104 18 22 22 CD cord-005453-4057qib7 9104 19 ( ( -LRB- cord-005453-4057qib7 9104 20 76 76 CD cord-005453-4057qib7 9104 21 % % NN cord-005453-4057qib7 9104 22 ) ) -RRB- cord-005453-4057qib7 9104 23 patients patient NNS cord-005453-4057qib7 9104 24 , , , cord-005453-4057qib7 9104 25 and and CC cord-005453-4057qib7 9104 26 active active JJ cord-005453-4057qib7 9104 27 at at IN cord-005453-4057qib7 9104 28 letermovir letermovir NNP cord-005453-4057qib7 9104 29 initiation initiation NN cord-005453-4057qib7 9104 30 in in IN cord-005453-4057qib7 9104 31 17 17 CD cord-005453-4057qib7 9104 32 ( ( -LRB- cord-005453-4057qib7 9104 33 59 59 CD cord-005453-4057qib7 9104 34 % % NN cord-005453-4057qib7 9104 35 ) ) -RRB- cord-005453-4057qib7 9104 36 . . . cord-005453-4057qib7 9105 1 Thirty thirty CD cord-005453-4057qib7 9105 2 two two CD cord-005453-4057qib7 9105 3 ( ( -LRB- cord-005453-4057qib7 9105 4 91 91 CD cord-005453-4057qib7 9105 5 % % NN cord-005453-4057qib7 9105 6 ) ) -RRB- cord-005453-4057qib7 9105 7 patients patient NNS cord-005453-4057qib7 9105 8 were be VBD cord-005453-4057qib7 9105 9 planned plan VBN cord-005453-4057qib7 9105 10 to to TO cord-005453-4057qib7 9105 11 receive receive VB cord-005453-4057qib7 9105 12 immunosuppressants immunosuppressant NNS cord-005453-4057qib7 9105 13 . . . cord-005453-4057qib7 9106 1 Donor donor NN cord-005453-4057qib7 9106 2 's 's POS cord-005453-4057qib7 9106 3 CMV CMV NNP cord-005453-4057qib7 9106 4 serology serology NN cord-005453-4057qib7 9106 5 was be VBD cord-005453-4057qib7 9106 6 negative negative JJ cord-005453-4057qib7 9106 7 in in IN cord-005453-4057qib7 9106 8 12/15 12/15 CD cord-005453-4057qib7 9106 9 ( ( -LRB- cord-005453-4057qib7 9106 10 80 80 CD cord-005453-4057qib7 9106 11 % % NN cord-005453-4057qib7 9106 12 ) ) -RRB- cord-005453-4057qib7 9106 13 ( ( -LRB- cord-005453-4057qib7 9106 14 20 20 CD cord-005453-4057qib7 9106 15 md md NNP cord-005453-4057qib7 9106 16 ) ) -RRB- cord-005453-4057qib7 9106 17 . . . cord-005453-4057qib7 9107 1 At at IN cord-005453-4057qib7 9107 2 baseline baseline NN cord-005453-4057qib7 9107 3 , , , cord-005453-4057qib7 9107 4 CMV CMV NNP cord-005453-4057qib7 9107 5 PCR PCR NNP cord-005453-4057qib7 9107 6 was be VBD cord-005453-4057qib7 9107 7 detectable detectable JJ cord-005453-4057qib7 9107 8 in in IN cord-005453-4057qib7 9107 9 1/35 1/35 CD cord-005453-4057qib7 9107 10 patients patient NNS cord-005453-4057qib7 9107 11 . . . cord-005453-4057qib7 9108 1 Letermovir Letermovir NNP cord-005453-4057qib7 9108 2 was be VBD cord-005453-4057qib7 9108 3 initiated initiate VBN cord-005453-4057qib7 9108 4 a a DT cord-005453-4057qib7 9108 5 median median NN cord-005453-4057qib7 9108 6 of of IN cord-005453-4057qib7 9108 7 195 195 CD cord-005453-4057qib7 9108 8 days day NNS cord-005453-4057qib7 9108 9 ( ( -LRB- cord-005453-4057qib7 9108 10 IQR iqr NN cord-005453-4057qib7 9108 11 : : : cord-005453-4057qib7 9108 12 154 154 CD cord-005453-4057qib7 9108 13 - - SYM cord-005453-4057qib7 9108 14 308 308 CD cord-005453-4057qib7 9108 15 ) ) -RRB- cord-005453-4057qib7 9108 16 after after IN cord-005453-4057qib7 9108 17 transplant transplant NN cord-005453-4057qib7 9108 18 for for IN cord-005453-4057qib7 9108 19 a a DT cord-005453-4057qib7 9108 20 mean mean JJ cord-005453-4057qib7 9108 21 duration duration NN cord-005453-4057qib7 9108 22 of of IN cord-005453-4057qib7 9108 23 112 112 CD cord-005453-4057qib7 9108 24 ± ± CD cord-005453-4057qib7 9108 25 47 47 CD cord-005453-4057qib7 9108 26 days day NNS cord-005453-4057qib7 9108 27 . . . cord-005453-4057qib7 9109 1 Only only RB cord-005453-4057qib7 9109 2 one one CD cord-005453-4057qib7 9109 3 ( ( -LRB- cord-005453-4057qib7 9109 4 3 3 CD cord-005453-4057qib7 9109 5 % % NN cord-005453-4057qib7 9109 6 ) ) -RRB- cord-005453-4057qib7 9109 7 patient patient NN cord-005453-4057qib7 9109 8 developed develop VBD cord-005453-4057qib7 9109 9 CMV CMV NNP cord-005453-4057qib7 9109 10 breakthrough breakthrough NN cord-005453-4057qib7 9109 11 . . . cord-005453-4057qib7 9110 1 The the DT cord-005453-4057qib7 9110 2 median median JJ cord-005453-4057qib7 9110 3 follow follow NN cord-005453-4057qib7 9110 4 - - HYPH cord-005453-4057qib7 9110 5 up up NN cord-005453-4057qib7 9110 6 from from IN cord-005453-4057qib7 9110 7 letermovir letermovir NNP cord-005453-4057qib7 9110 8 initiation initiation NN cord-005453-4057qib7 9110 9 was be VBD cord-005453-4057qib7 9110 10 103 103 CD cord-005453-4057qib7 9110 11 days day NNS cord-005453-4057qib7 9110 12 . . . cord-005453-4057qib7 9111 1 Among among IN cord-005453-4057qib7 9111 2 the the DT cord-005453-4057qib7 9111 3 57 57 CD cord-005453-4057qib7 9111 4 patients patient NNS cord-005453-4057qib7 9111 5 exposed expose VBN cord-005453-4057qib7 9111 6 to to IN cord-005453-4057qib7 9111 7 letermovir letermovir NNP cord-005453-4057qib7 9111 8 prophylaxis prophylaxis NN cord-005453-4057qib7 9111 9 , , , cord-005453-4057qib7 9111 10 two two CD cord-005453-4057qib7 9111 11 patients patient NNS cord-005453-4057qib7 9111 12 permanently permanently RB cord-005453-4057qib7 9111 13 discontinued discontinue VBN cord-005453-4057qib7 9111 14 because because IN cord-005453-4057qib7 9111 15 of of IN cord-005453-4057qib7 9111 16 letermovir letermovir NNS cord-005453-4057qib7 9111 17 - - HYPH cord-005453-4057qib7 9111 18 related relate VBN cord-005453-4057qib7 9111 19 adverse adverse JJ cord-005453-4057qib7 9111 20 events event NNS cord-005453-4057qib7 9111 21 ( ( -LRB- cord-005453-4057qib7 9111 22 acute acute JJ cord-005453-4057qib7 9111 23 GvHD gvhd NN cord-005453-4057qib7 9111 24 and and CC cord-005453-4057qib7 9111 25 nephropathy nephropathy NN cord-005453-4057qib7 9111 26 for for IN cord-005453-4057qib7 9111 27 one one CD cord-005453-4057qib7 9111 28 , , , cord-005453-4057qib7 9111 29 loss loss NN cord-005453-4057qib7 9111 30 of of IN cord-005453-4057qib7 9111 31 appetite appetite NN cord-005453-4057qib7 9111 32 , , , cord-005453-4057qib7 9111 33 pruritus pruritus NN cord-005453-4057qib7 9111 34 , , , cord-005453-4057qib7 9111 35 diarrhoea diarrhoea NN cord-005453-4057qib7 9111 36 and and CC cord-005453-4057qib7 9111 37 weight weight NN cord-005453-4057qib7 9111 38 loss loss NN cord-005453-4057qib7 9111 39 for for IN cord-005453-4057qib7 9111 40 the the DT cord-005453-4057qib7 9111 41 other other JJ cord-005453-4057qib7 9111 42 ) ) -RRB- cord-005453-4057qib7 9111 43 ; ; : cord-005453-4057qib7 9111 44 two two CD cord-005453-4057qib7 9111 45 deaths death NNS cord-005453-4057qib7 9111 46 occurred occur VBD cord-005453-4057qib7 9111 47 with with IN cord-005453-4057qib7 9111 48 no no DT cord-005453-4057qib7 9111 49 causal causal JJ cord-005453-4057qib7 9111 50 relationship relationship NN cord-005453-4057qib7 9111 51 to to IN cord-005453-4057qib7 9111 52 letermovir letermovir NNP cord-005453-4057qib7 9111 53 . . . cord-005453-4057qib7 9112 1 Data datum NNS cord-005453-4057qib7 9112 2 were be VBD cord-005453-4057qib7 9112 3 consistent consistent JJ cord-005453-4057qib7 9112 4 with with IN cord-005453-4057qib7 9112 5 the the DT cord-005453-4057qib7 9112 6 known know VBN cord-005453-4057qib7 9112 7 safety safety NN cord-005453-4057qib7 9112 8 profile profile NN cord-005453-4057qib7 9112 9 of of IN cord-005453-4057qib7 9112 10 letermovir letermovir NNP cord-005453-4057qib7 9112 11 . . . cord-005453-4057qib7 9113 1 Conclusions conclusion NNS cord-005453-4057qib7 9113 2 : : : cord-005453-4057qib7 9114 1 Letermovir Letermovir NNP cord-005453-4057qib7 9114 2 is be VBZ cord-005453-4057qib7 9114 3 or or CC cord-005453-4057qib7 9114 4 will will MD cord-005453-4057qib7 9114 5 be be VB cord-005453-4057qib7 9114 6 soonly soonly RB cord-005453-4057qib7 9114 7 available available JJ cord-005453-4057qib7 9114 8 in in IN cord-005453-4057qib7 9114 9 most most JJS cord-005453-4057qib7 9114 10 European european JJ cord-005453-4057qib7 9114 11 countries country NNS cord-005453-4057qib7 9114 12 for for IN cord-005453-4057qib7 9114 13 CMV CMV NNP cord-005453-4057qib7 9114 14 prophylaxis prophylaxis NN cord-005453-4057qib7 9114 15 in in IN cord-005453-4057qib7 9114 16 HCT HCT NNP cord-005453-4057qib7 9114 17 recipients recipient NNS cord-005453-4057qib7 9114 18 . . . cord-005453-4057qib7 9115 1 Pending pende VBG cord-005453-4057qib7 9115 2 its -PRON- PRP$ cord-005453-4057qib7 9115 3 routine routine JJ cord-005453-4057qib7 9115 4 use use NN cord-005453-4057qib7 9115 5 , , , cord-005453-4057qib7 9115 6 letermovir letermovir NNS cord-005453-4057qib7 9115 7 used use VBN cord-005453-4057qib7 9115 8 as as IN cord-005453-4057qib7 9115 9 SP SP NNP cord-005453-4057qib7 9115 10 was be VBD cord-005453-4057qib7 9115 11 well well RB cord-005453-4057qib7 9115 12 tolerated tolerate VBN cord-005453-4057qib7 9115 13 and and CC cord-005453-4057qib7 9115 14 effective effective JJ cord-005453-4057qib7 9115 15 , , , cord-005453-4057qib7 9115 16 with with IN cord-005453-4057qib7 9115 17 only only RB cord-005453-4057qib7 9115 18 1/35 1/35 CD cord-005453-4057qib7 9115 19 patients patient NNS cord-005453-4057qib7 9115 20 developing develop VBG cord-005453-4057qib7 9115 21 a a DT cord-005453-4057qib7 9115 22 breakthrough breakthrough NN cord-005453-4057qib7 9115 23 infection infection NN cord-005453-4057qib7 9115 24 . . . cord-005453-4057qib7 9116 1 In in IN cord-005453-4057qib7 9116 2 this this DT cord-005453-4057qib7 9116 3 high high JJ cord-005453-4057qib7 9116 4 - - HYPH cord-005453-4057qib7 9116 5 risk risk NN cord-005453-4057qib7 9116 6 population population NN cord-005453-4057qib7 9116 7 for for IN cord-005453-4057qib7 9116 8 CMV CMV NNP cord-005453-4057qib7 9116 9 recurrence recurrence NN cord-005453-4057qib7 9116 10 , , , cord-005453-4057qib7 9116 11 letermovir letermovir NNS cord-005453-4057qib7 9116 12 may may MD cord-005453-4057qib7 9116 13 provide provide VB cord-005453-4057qib7 9116 14 a a DT cord-005453-4057qib7 9116 15 safe safe JJ cord-005453-4057qib7 9116 16 bridge bridge NN cord-005453-4057qib7 9116 17 between between IN cord-005453-4057qib7 9116 18 PET pet NN cord-005453-4057qib7 9116 19 and and CC cord-005453-4057qib7 9116 20 specific specific JJ cord-005453-4057qib7 9116 21 immune immune JJ cord-005453-4057qib7 9116 22 reconstitution reconstitution NN cord-005453-4057qib7 9116 23 , , , cord-005453-4057qib7 9116 24 pending pende VBG cord-005453-4057qib7 9116 25 tapering taper VBG cord-005453-4057qib7 9116 26 or or CC cord-005453-4057qib7 9116 27 discontinuation discontinuation NN cord-005453-4057qib7 9116 28 of of IN cord-005453-4057qib7 9116 29 immunosuppressants immunosuppressant NNS cord-005453-4057qib7 9116 30 . . . cord-005453-4057qib7 9117 1 Whether whether IN cord-005453-4057qib7 9117 2 SP SP NNP cord-005453-4057qib7 9117 3 may may MD cord-005453-4057qib7 9117 4 improve improve VB cord-005453-4057qib7 9117 5 survival survival NN cord-005453-4057qib7 9117 6 deserves deserve VBZ cord-005453-4057qib7 9117 7 further further JJ cord-005453-4057qib7 9117 8 studies study NNS cord-005453-4057qib7 9117 9 . . . cord-005453-4057qib7 9118 1 Disclosure disclosure NN cord-005453-4057qib7 9118 2 : : : cord-005453-4057qib7 9119 1 Thierry Thierry NNP cord-005453-4057qib7 9119 2 Allavoine Allavoine NNP cord-005453-4057qib7 9119 3 is be VBZ cord-005453-4057qib7 9119 4 a a DT cord-005453-4057qib7 9119 5 former former JJ cord-005453-4057qib7 9119 6 employee employee NN cord-005453-4057qib7 9119 7 of of IN cord-005453-4057qib7 9119 8 MSD MSD NNP cord-005453-4057qib7 9119 9 France France NNP cord-005453-4057qib7 9119 10 , , , cord-005453-4057qib7 9119 11 Nathalie Nathalie NNP cord-005453-4057qib7 9119 12 Benard Benard NNP cord-005453-4057qib7 9119 13 and and CC cord-005453-4057qib7 9119 14 Amir Amir NNP cord-005453-4057qib7 9119 15 Guidoum Guidoum NNP cord-005453-4057qib7 9119 16 are be VBP cord-005453-4057qib7 9119 17 employees employee NNS cord-005453-4057qib7 9119 18 of of IN cord-005453-4057qib7 9119 19 MSD MSD NNP cord-005453-4057qib7 9119 20 France France NNP cord-005453-4057qib7 9119 21 , , , cord-005453-4057qib7 9119 22 Marion Marion NNP cord-005453-4057qib7 9119 23 Masure Masure NNP cord-005453-4057qib7 9119 24 is be VBZ cord-005453-4057qib7 9119 25 an an DT cord-005453-4057qib7 9119 26 employee employee NN cord-005453-4057qib7 9119 27 of of IN cord-005453-4057qib7 9119 28 ICTA ICTA NNP cord-005453-4057qib7 9119 29 PM PM NNP cord-005453-4057qib7 9119 30 , , , cord-005453-4057qib7 9119 31 Sophie Sophie NNP cord-005453-4057qib7 9119 32 Alain Alain NNP cord-005453-4057qib7 9119 33 and and CC cord-005453-4057qib7 9119 34 Catherine Catherine NNP cord-005453-4057qib7 9119 35 Cordonnier Cordonnier NNP cord-005453-4057qib7 9119 36 have have VBP cord-005453-4057qib7 9119 37 participated participate VBN cord-005453-4057qib7 9119 38 in in IN cord-005453-4057qib7 9119 39 advisory advisory JJ cord-005453-4057qib7 9119 40 boards board NNS cord-005453-4057qib7 9119 41 and and CC cord-005453-4057qib7 9119 42 have have VBP cord-005453-4057qib7 9119 43 been be VBN cord-005453-4057qib7 9119 44 members member NNS cord-005453-4057qib7 9119 45 of of IN cord-005453-4057qib7 9119 46 the the DT cord-005453-4057qib7 9119 47 speaker speaker NNP cord-005453-4057qib7 9119 48 bureau bureau NNP cord-005453-4057qib7 9119 49 of of IN cord-005453-4057qib7 9119 50 MSD MSD NNP cord-005453-4057qib7 9119 51 . . . cord-005453-4057qib7 9120 1 Ibrahim Ibrahim NNP cord-005453-4057qib7 9120 2 Yacoub Yacoub NNP cord-005453-4057qib7 9120 3 - - HYPH cord-005453-4057qib7 9120 4 Agha Agha NNP cord-005453-4057qib7 9120 5 has have VBZ cord-005453-4057qib7 9120 6 received receive VBN cord-005453-4057qib7 9120 7 honoraria honorarium NNS cord-005453-4057qib7 9120 8 from from IN cord-005453-4057qib7 9120 9 MSD MSD NNP cord-005453-4057qib7 9120 10 , , , cord-005453-4057qib7 9120 11 Other other JJ cord-005453-4057qib7 9120 12 authors author NNS cord-005453-4057qib7 9120 13 : : : cord-005453-4057qib7 9120 14 nothing nothing NN cord-005453-4057qib7 9120 15 to to TO cord-005453-4057qib7 9120 16 declare declare VB cord-005453-4057qib7 9120 17 P407 P407 NNP cord-005453-4057qib7 9120 18 Real real JJ cord-005453-4057qib7 9120 19 - - HYPH cord-005453-4057qib7 9120 20 world world NN cord-005453-4057qib7 9120 21 data datum NNS cord-005453-4057qib7 9120 22 on on IN cord-005453-4057qib7 9120 23 letermovir letermovir NNP cord-005453-4057qib7 9120 24 prophylaxis prophylaxis NN cord-005453-4057qib7 9120 25 for for IN cord-005453-4057qib7 9120 26 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 9120 27 reactivation reactivation NN cord-005453-4057qib7 9120 28 after after IN cord-005453-4057qib7 9120 29 allogeneic allogeneic JJ cord-005453-4057qib7 9120 30 hematopoietic hematopoietic JJ cord-005453-4057qib7 9120 31 cell cell NN cord-005453-4057qib7 9120 32 transplantation transplantation NN cord-005453-4057qib7 9120 33 : : : cord-005453-4057qib7 9120 34 A a DT cord-005453-4057qib7 9120 35 single single JJ cord-005453-4057qib7 9120 36 center center NN cord-005453-4057qib7 9120 37 experience experience NN cord-005453-4057qib7 9120 38 Patrick Patrick NNP cord-005453-4057qib7 9120 39 Derigs Derigs NNP cord-005453-4057qib7 9120 40 1 1 CD cord-005453-4057qib7 9120 41 , , , cord-005453-4057qib7 9120 42 Maria Maria NNP cord-005453-4057qib7 9120 43 - - HYPH cord-005453-4057qib7 9120 44 Luisa Luisa NNP cord-005453-4057qib7 9120 45 Schubert Schubert NNP cord-005453-4057qib7 9120 46 1 1 CD cord-005453-4057qib7 9120 47 , , , cord-005453-4057qib7 9120 48 Paul Paul NNP cord-005453-4057qib7 9120 49 Schnitzler Schnitzler NNP cord-005453-4057qib7 9120 50 1 1 CD cord-005453-4057qib7 9120 51 , , , cord-005453-4057qib7 9120 52 Carsten Carsten NNP cord-005453-4057qib7 9120 53 Müller Müller NNP cord-005453-4057qib7 9120 54 - - HYPH cord-005453-4057qib7 9120 55 Tidow Tidow NNP cord-005453-4057qib7 9120 56 1 1 CD cord-005453-4057qib7 9120 57 , , , cord-005453-4057qib7 9120 58 Peter Peter NNP cord-005453-4057qib7 9120 59 Dreger Dreger NNP cord-005453-4057qib7 9120 60 1 1 CD cord-005453-4057qib7 9120 61 , , , cord-005453-4057qib7 9120 62 Michael Michael NNP cord-005453-4057qib7 9120 63 Schmitt Schmitt NNP cord-005453-4057qib7 9120 64 1 1 CD cord-005453-4057qib7 9120 65 1 1 CD cord-005453-4057qib7 9120 66 Heidelberg Heidelberg NNP cord-005453-4057qib7 9120 67 University University NNP cord-005453-4057qib7 9120 68 Hospital Hospital NNP cord-005453-4057qib7 9120 69 , , , cord-005453-4057qib7 9120 70 Heidelberg Heidelberg NNP cord-005453-4057qib7 9120 71 , , , cord-005453-4057qib7 9120 72 Germany Germany NNP cord-005453-4057qib7 9120 73 , , , cord-005453-4057qib7 9120 74 Background background NN cord-005453-4057qib7 9120 75 : : : cord-005453-4057qib7 9120 76 Reactivation reactivation NN cord-005453-4057qib7 9120 77 of of IN cord-005453-4057qib7 9120 78 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 9120 79 ( ( -LRB- cord-005453-4057qib7 9120 80 CMV CMV NNP cord-005453-4057qib7 9120 81 ) ) -RRB- cord-005453-4057qib7 9120 82 still still RB cord-005453-4057qib7 9120 83 contributes contribute VBZ cord-005453-4057qib7 9120 84 substantially substantially RB cord-005453-4057qib7 9120 85 to to IN cord-005453-4057qib7 9120 86 morbidity morbidity NN cord-005453-4057qib7 9120 87 and and CC cord-005453-4057qib7 9120 88 mortality mortality NN cord-005453-4057qib7 9120 89 after after IN cord-005453-4057qib7 9120 90 allogeneic allogeneic JJ cord-005453-4057qib7 9120 91 hematopoietic hematopoietic JJ cord-005453-4057qib7 9120 92 cell cell NN cord-005453-4057qib7 9120 93 transplantation transplantation NN cord-005453-4057qib7 9120 94 ( ( -LRB- cord-005453-4057qib7 9120 95 alloHCT alloHCT NNP cord-005453-4057qib7 9120 96 ) ) -RRB- cord-005453-4057qib7 9120 97 . . . cord-005453-4057qib7 9121 1 Recently recently RB cord-005453-4057qib7 9121 2 , , , cord-005453-4057qib7 9121 3 letermovir letermovir NNP cord-005453-4057qib7 9121 4 became become VBD cord-005453-4057qib7 9121 5 available available JJ cord-005453-4057qib7 9121 6 as as IN cord-005453-4057qib7 9121 7 the the DT cord-005453-4057qib7 9121 8 first first JJ cord-005453-4057qib7 9121 9 drug drug NN cord-005453-4057qib7 9121 10 approved approve VBN cord-005453-4057qib7 9121 11 in in IN cord-005453-4057qib7 9121 12 Europe Europe NNP cord-005453-4057qib7 9121 13 for for IN cord-005453-4057qib7 9121 14 prophylaxis prophylaxis NN cord-005453-4057qib7 9121 15 of of IN cord-005453-4057qib7 9121 16 CMV CMV NNP cord-005453-4057qib7 9121 17 reactivation reactivation NN cord-005453-4057qib7 9121 18 in in IN cord-005453-4057qib7 9121 19 seropositive seropositive JJ cord-005453-4057qib7 9121 20 patients patient NNS cord-005453-4057qib7 9121 21 who who WP cord-005453-4057qib7 9121 22 have have VBP cord-005453-4057qib7 9121 23 undergone undergo VBN cord-005453-4057qib7 9121 24 alloHCT allohct XX cord-005453-4057qib7 9121 25 . . . cord-005453-4057qib7 9122 1 Letermovir Letermovir NNP cord-005453-4057qib7 9122 2 is be VBZ cord-005453-4057qib7 9122 3 neither neither CC cord-005453-4057qib7 9122 4 myelo myelo NN cord-005453-4057qib7 9122 5 - - , cord-005453-4057qib7 9122 6 nor nor CC cord-005453-4057qib7 9122 7 nephrotoxic nephrotoxic NNP cord-005453-4057qib7 9122 8 , , , cord-005453-4057qib7 9122 9 and and CC cord-005453-4057qib7 9122 10 significantly significantly RB cord-005453-4057qib7 9122 11 reduced reduce VBD cord-005453-4057qib7 9122 12 the the DT cord-005453-4057qib7 9122 13 incidence incidence NN cord-005453-4057qib7 9122 14 of of IN cord-005453-4057qib7 9122 15 CMV CMV NNP cord-005453-4057qib7 9122 16 reactivation reactivation NN cord-005453-4057qib7 9122 17 in in IN cord-005453-4057qib7 9122 18 a a DT cord-005453-4057qib7 9122 19 pivotal pivotal JJ cord-005453-4057qib7 9122 20 phase phase NN cord-005453-4057qib7 9122 21 III iii CD cord-005453-4057qib7 9122 22 trial trial NN cord-005453-4057qib7 9122 23 ( ( -LRB- cord-005453-4057qib7 9122 24 NEJM NEJM NNP cord-005453-4057qib7 9122 25 2017 2017 CD cord-005453-4057qib7 9122 26 ; ; : cord-005453-4057qib7 9122 27 377:2433 377:2433 NNP cord-005453-4057qib7 9122 28 ) ) -RRB- cord-005453-4057qib7 9122 29 . . . cord-005453-4057qib7 9123 1 Therefore therefore RB cord-005453-4057qib7 9123 2 we -PRON- PRP cord-005453-4057qib7 9123 3 adopted adopt VBD cord-005453-4057qib7 9123 4 letermovir letermovir NNP cord-005453-4057qib7 9123 5 prophylaxis prophylaxis NN cord-005453-4057qib7 9123 6 according accord VBG cord-005453-4057qib7 9123 7 to to IN cord-005453-4057qib7 9123 8 the the DT cord-005453-4057qib7 9123 9 label label NN cord-005453-4057qib7 9123 10 as as IN cord-005453-4057qib7 9123 11 standard standard JJ cord-005453-4057qib7 9123 12 policy policy NN cord-005453-4057qib7 9123 13 in in IN cord-005453-4057qib7 9123 14 our -PRON- PRP$ cord-005453-4057qib7 9123 15 institution institution NN cord-005453-4057qib7 9123 16 : : : cord-005453-4057qib7 9124 1 In in IN cord-005453-4057qib7 9124 2 seropositive seropositive JJ cord-005453-4057qib7 9124 3 recipients recipient NNS cord-005453-4057qib7 9124 4 letermovir letermovir NNS cord-005453-4057qib7 9124 5 was be VBD cord-005453-4057qib7 9124 6 initiated initiate VBN cord-005453-4057qib7 9124 7 after after IN cord-005453-4057qib7 9124 8 engraftment engraftment NN cord-005453-4057qib7 9124 9 and and CC cord-005453-4057qib7 9124 10 continued continue VBD cord-005453-4057qib7 9124 11 until until IN cord-005453-4057qib7 9124 12 day day NN cord-005453-4057qib7 9124 13 +100 +100 NNS cord-005453-4057qib7 9124 14 or or CC cord-005453-4057qib7 9124 15 CMV CMV NNP cord-005453-4057qib7 9124 16 reactivation reactivation NN cord-005453-4057qib7 9124 17 . . . cord-005453-4057qib7 9125 1 The the DT cord-005453-4057qib7 9125 2 aim aim NN cord-005453-4057qib7 9125 3 of of IN cord-005453-4057qib7 9125 4 the the DT cord-005453-4057qib7 9125 5 present present JJ cord-005453-4057qib7 9125 6 study study NN cord-005453-4057qib7 9125 7 was be VBD cord-005453-4057qib7 9125 8 to to TO cord-005453-4057qib7 9125 9 investigate investigate VB cord-005453-4057qib7 9125 10 if if IN cord-005453-4057qib7 9125 11 the the DT cord-005453-4057qib7 9125 12 favorable favorable JJ cord-005453-4057qib7 9125 13 trial trial NN cord-005453-4057qib7 9125 14 results result NNS cord-005453-4057qib7 9125 15 could could MD cord-005453-4057qib7 9125 16 be be VB cord-005453-4057qib7 9125 17 reproduced reproduce VBN cord-005453-4057qib7 9125 18 under under IN cord-005453-4057qib7 9125 19 real real JJ cord-005453-4057qib7 9125 20 - - HYPH cord-005453-4057qib7 9125 21 world world NN cord-005453-4057qib7 9125 22 conditions condition NNS cord-005453-4057qib7 9125 23 . . . cord-005453-4057qib7 9126 1 Methods method NNS cord-005453-4057qib7 9126 2 : : : cord-005453-4057qib7 9126 3 The the DT cord-005453-4057qib7 9126 4 study study NN cord-005453-4057qib7 9126 5 cohort cohort NN cord-005453-4057qib7 9126 6 consisted consist VBD cord-005453-4057qib7 9126 7 of of IN cord-005453-4057qib7 9126 8 the the DT cord-005453-4057qib7 9126 9 first first JJ cord-005453-4057qib7 9126 10 seropositive seropositive JJ cord-005453-4057qib7 9126 11 35 35 CD cord-005453-4057qib7 9126 12 patients patient NNS cord-005453-4057qib7 9126 13 who who WP cord-005453-4057qib7 9126 14 received receive VBD cord-005453-4057qib7 9126 15 letermovir letermovir NNS cord-005453-4057qib7 9126 16 prophylaxis prophylaxis NN cord-005453-4057qib7 9126 17 at at IN cord-005453-4057qib7 9126 18 our -PRON- PRP$ cord-005453-4057qib7 9126 19 institution institution NN cord-005453-4057qib7 9126 20 ( ( -LRB- cord-005453-4057qib7 9126 21 between between IN cord-005453-4057qib7 9126 22 March March NNP cord-005453-4057qib7 9126 23 and and CC cord-005453-4057qib7 9126 24 August August NNP cord-005453-4057qib7 9126 25 2018 2018 CD cord-005453-4057qib7 9126 26 ) ) -RRB- cord-005453-4057qib7 9126 27 . . . cord-005453-4057qib7 9127 1 These these DT cord-005453-4057qib7 9127 2 were be VBD cord-005453-4057qib7 9127 3 compared compare VBN cord-005453-4057qib7 9127 4 with with IN cord-005453-4057qib7 9127 5 a a DT cord-005453-4057qib7 9127 6 control control NN cord-005453-4057qib7 9127 7 cohort cohort NN cord-005453-4057qib7 9127 8 transplanted transplant VBN cord-005453-4057qib7 9127 9 between between IN cord-005453-4057qib7 9127 10 August August NNP cord-005453-4057qib7 9127 11 2017 2017 CD cord-005453-4057qib7 9127 12 and and CC cord-005453-4057qib7 9127 13 March March NNP cord-005453-4057qib7 9127 14 2018 2018 CD cord-005453-4057qib7 9127 15 before before IN cord-005453-4057qib7 9127 16 the the DT cord-005453-4057qib7 9127 17 advent advent NN cord-005453-4057qib7 9127 18 of of IN cord-005453-4057qib7 9127 19 letermovir letermovir NNP cord-005453-4057qib7 9127 20 . . . cord-005453-4057qib7 9128 1 Study study VB cord-005453-4057qib7 9128 2 and and CC cord-005453-4057qib7 9128 3 control control NN cord-005453-4057qib7 9128 4 cohorts cohort NNS cord-005453-4057qib7 9128 5 were be VBD cord-005453-4057qib7 9128 6 matched match VBN cord-005453-4057qib7 9128 7 for for IN cord-005453-4057qib7 9128 8 CMV CMV NNP cord-005453-4057qib7 9128 9 donor donor NN cord-005453-4057qib7 9128 10 / / SYM cord-005453-4057qib7 9128 11 recipient recipient NN cord-005453-4057qib7 9128 12 sero sero NN cord-005453-4057qib7 9128 13 - - HYPH cord-005453-4057qib7 9128 14 status status NN cord-005453-4057qib7 9128 15 , , , cord-005453-4057qib7 9128 16 underlying underlie VBG cord-005453-4057qib7 9128 17 disease disease NN cord-005453-4057qib7 9128 18 and and CC cord-005453-4057qib7 9128 19 donor donor NN cord-005453-4057qib7 9128 20 type type NN cord-005453-4057qib7 9128 21 source source NN cord-005453-4057qib7 9128 22 of of IN cord-005453-4057qib7 9128 23 stem stem NN cord-005453-4057qib7 9128 24 cells cell NNS cord-005453-4057qib7 9128 25 and and CC cord-005453-4057qib7 9128 26 application application NN cord-005453-4057qib7 9128 27 of of IN cord-005453-4057qib7 9128 28 ATG ATG NNP cord-005453-4057qib7 9128 29 . . . cord-005453-4057qib7 9129 1 CMV CMV NNP cord-005453-4057qib7 9129 2 viremia viremia NN cord-005453-4057qib7 9129 3 was be VBD cord-005453-4057qib7 9129 4 monitored monitor VBN cord-005453-4057qib7 9129 5 by by IN cord-005453-4057qib7 9129 6 a a DT cord-005453-4057qib7 9129 7 quantitative quantitative JJ cord-005453-4057qib7 9129 8 PCR PCR NNP cord-005453-4057qib7 9129 9 twice twice PDT cord-005453-4057qib7 9129 10 a a DT cord-005453-4057qib7 9129 11 week week NN cord-005453-4057qib7 9129 12 during during IN cord-005453-4057qib7 9129 13 the the DT cord-005453-4057qib7 9129 14 inpatient inpatient JJ cord-005453-4057qib7 9129 15 period period NN cord-005453-4057qib7 9129 16 and and CC cord-005453-4057qib7 9129 17 weekly weekly NN cord-005453-4057qib7 9129 18 thereafter thereafter RB cord-005453-4057qib7 9129 19 . . . cord-005453-4057qib7 9130 1 Patients patient NNS cord-005453-4057qib7 9130 2 reactivating reactivate VBG cord-005453-4057qib7 9130 3 CMV CMV NNP cord-005453-4057qib7 9130 4 prior prior RB cord-005453-4057qib7 9130 5 to to IN cord-005453-4057qib7 9130 6 engraftment engraftment NN cord-005453-4057qib7 9130 7 were be VBD cord-005453-4057qib7 9130 8 not not RB cord-005453-4057qib7 9130 9 considered consider VBN cord-005453-4057qib7 9130 10 as as IN cord-005453-4057qib7 9130 11 event event NN cord-005453-4057qib7 9130 12 in in IN cord-005453-4057qib7 9130 13 both both DT cord-005453-4057qib7 9130 14 groups group NNS cord-005453-4057qib7 9130 15 . . . cord-005453-4057qib7 9131 1 Results result NNS cord-005453-4057qib7 9131 2 : : : cord-005453-4057qib7 9132 1 No no DT cord-005453-4057qib7 9132 2 major major JJ cord-005453-4057qib7 9132 3 side side NN cord-005453-4057qib7 9132 4 effects effect NNS cord-005453-4057qib7 9132 5 of of IN cord-005453-4057qib7 9132 6 letermovir letermovir NNS cord-005453-4057qib7 9132 7 intake intake NN cord-005453-4057qib7 9132 8 were be VBD cord-005453-4057qib7 9132 9 observed observe VBN cord-005453-4057qib7 9132 10 . . . cord-005453-4057qib7 9133 1 With with IN cord-005453-4057qib7 9133 2 altogether altogether RB cord-005453-4057qib7 9133 3 5 5 CD cord-005453-4057qib7 9133 4 reactivation reactivation NN cord-005453-4057qib7 9133 5 events event NNS cord-005453-4057qib7 9133 6 , , , cord-005453-4057qib7 9133 7 the the DT cord-005453-4057qib7 9133 8 cumulative cumulative JJ cord-005453-4057qib7 9133 9 rate rate NN cord-005453-4057qib7 9133 10 of of IN cord-005453-4057qib7 9133 11 CMV CMV NNP cord-005453-4057qib7 9133 12 reactivation reactivation NN cord-005453-4057qib7 9133 13 on on IN cord-005453-4057qib7 9133 14 day day NN cord-005453-4057qib7 9133 15 +100 +100 NNP cord-005453-4057qib7 9133 16 was be VBD cord-005453-4057qib7 9133 17 14 14 CD cord-005453-4057qib7 9133 18 % % NN cord-005453-4057qib7 9133 19 ( ( -LRB- cord-005453-4057qib7 9133 20 95%CI 95%ci CD cord-005453-4057qib7 9133 21 1 1 CD cord-005453-4057qib7 9133 22 - - SYM cord-005453-4057qib7 9133 23 45 45 CD cord-005453-4057qib7 9133 24 % % NN cord-005453-4057qib7 9133 25 ) ) -RRB- cord-005453-4057qib7 9133 26 in in IN cord-005453-4057qib7 9133 27 the the DT cord-005453-4057qib7 9133 28 letermovir letermovir NNP cord-005453-4057qib7 9133 29 cohort cohort NN cord-005453-4057qib7 9133 30 and and CC cord-005453-4057qib7 9133 31 thus thus RB cord-005453-4057qib7 9133 32 significantly significantly RB cord-005453-4057qib7 9133 33 lower low JJR cord-005453-4057qib7 9133 34 than than IN cord-005453-4057qib7 9133 35 in in IN cord-005453-4057qib7 9133 36 the the DT cord-005453-4057qib7 9133 37 control control NN cord-005453-4057qib7 9133 38 group group NN cord-005453-4057qib7 9133 39 ( ( -LRB- cord-005453-4057qib7 9133 40 20 20 CD cord-005453-4057qib7 9133 41 events event NNS cord-005453-4057qib7 9133 42 , , , cord-005453-4057qib7 9133 43 58 58 CD cord-005453-4057qib7 9133 44 % % NN cord-005453-4057qib7 9133 45 ( ( -LRB- cord-005453-4057qib7 9133 46 95%CI 95%ci CD cord-005453-4057qib7 9133 47 42 42 CD cord-005453-4057qib7 9133 48 - - SYM cord-005453-4057qib7 9133 49 71 71 CD cord-005453-4057qib7 9133 50 % % NN cord-005453-4057qib7 9133 51 ) ) -RRB- cord-005453-4057qib7 9133 52 ; ; : cord-005453-4057qib7 9133 53 HR HR NNP cord-005453-4057qib7 9133 54 0.23 0.23 CD cord-005453-4057qib7 9133 55 ( ( -LRB- cord-005453-4057qib7 9133 56 0.10 0.10 CD cord-005453-4057qib7 9133 57 - - SYM cord-005453-4057qib7 9133 58 0.51 0.51 CD cord-005453-4057qib7 9133 59 ) ) -RRB- cord-005453-4057qib7 9133 60 ; ; : cord-005453-4057qib7 9133 61 p=0.0003 p=0.0003 NNP cord-005453-4057qib7 9133 62 ) ) -RRB- cord-005453-4057qib7 9133 63 . . . cord-005453-4057qib7 9134 1 The the DT cord-005453-4057qib7 9134 2 median median JJ cord-005453-4057qib7 9134 3 time time NN cord-005453-4057qib7 9134 4 to to IN cord-005453-4057qib7 9134 5 reactivation reactivation NN cord-005453-4057qib7 9134 6 was be VBD cord-005453-4057qib7 9134 7 53 53 CD cord-005453-4057qib7 9134 8 days day NNS cord-005453-4057qib7 9134 9 for for IN cord-005453-4057qib7 9134 10 the the DT cord-005453-4057qib7 9134 11 control control NN cord-005453-4057qib7 9134 12 group group NN cord-005453-4057qib7 9134 13 and and CC cord-005453-4057qib7 9134 14 not not RB cord-005453-4057qib7 9134 15 reached reach VBN cord-005453-4057qib7 9134 16 for for IN cord-005453-4057qib7 9134 17 the the DT cord-005453-4057qib7 9134 18 letermovir letermovir NNP cord-005453-4057qib7 9134 19 group group NN cord-005453-4057qib7 9134 20 . . . cord-005453-4057qib7 9135 1 The the DT cord-005453-4057qib7 9135 2 cumulative cumulative JJ cord-005453-4057qib7 9135 3 number number NN cord-005453-4057qib7 9135 4 of of IN cord-005453-4057qib7 9135 5 days day NNS cord-005453-4057qib7 9135 6 on on IN cord-005453-4057qib7 9135 7 valganciclovir valganciclovir NNP cord-005453-4057qib7 9135 8 before before IN cord-005453-4057qib7 9135 9 d d NNP cord-005453-4057qib7 9135 10 +100 +100 NNP cord-005453-4057qib7 9135 11 was be VBD cord-005453-4057qib7 9135 12 151d 151d CD cord-005453-4057qib7 9135 13 for for IN cord-005453-4057qib7 9135 14 the the DT cord-005453-4057qib7 9135 15 35 35 CD cord-005453-4057qib7 9135 16 letermovir letermovir NNS cord-005453-4057qib7 9135 17 patients patient NNS cord-005453-4057qib7 9135 18 vs vs IN cord-005453-4057qib7 9135 19 689d 689d NNP cord-005453-4057qib7 9135 20 for for IN cord-005453-4057qib7 9135 21 the the DT cord-005453-4057qib7 9135 22 35 35 CD cord-005453-4057qib7 9135 23 control control NN cord-005453-4057qib7 9135 24 patients patient NNS cord-005453-4057qib7 9135 25 . . . cord-005453-4057qib7 9136 1 There there EX cord-005453-4057qib7 9136 2 were be VBD cord-005453-4057qib7 9136 3 no no DT cord-005453-4057qib7 9136 4 hospitalizations hospitalization NNS cord-005453-4057qib7 9136 5 for for IN cord-005453-4057qib7 9136 6 foscavir foscavir NNP cord-005453-4057qib7 9136 7 administration administration NN cord-005453-4057qib7 9136 8 in in IN cord-005453-4057qib7 9136 9 the the DT cord-005453-4057qib7 9136 10 letermovir letermovir NNP cord-005453-4057qib7 9136 11 group group NN cord-005453-4057qib7 9136 12 compared compare VBN cord-005453-4057qib7 9136 13 to to IN cord-005453-4057qib7 9136 14 5 5 CD cord-005453-4057qib7 9136 15 hospitalizations hospitalization NNS cord-005453-4057qib7 9136 16 in in IN cord-005453-4057qib7 9136 17 the the DT cord-005453-4057qib7 9136 18 control control NN cord-005453-4057qib7 9136 19 group group NN cord-005453-4057qib7 9136 20 . . . cord-005453-4057qib7 9137 1 There there EX cord-005453-4057qib7 9137 2 were be VBD cord-005453-4057qib7 9137 3 2 2 CD cord-005453-4057qib7 9137 4 deaths death NNS cord-005453-4057qib7 9137 5 before before IN cord-005453-4057qib7 9137 6 d d NNP cord-005453-4057qib7 9137 7 +100 +100 NNS cord-005453-4057qib7 9137 8 in in IN cord-005453-4057qib7 9137 9 the the DT cord-005453-4057qib7 9137 10 letermovir letermovir NNP cord-005453-4057qib7 9137 11 group group NNP cord-005453-4057qib7 9137 12 ( ( -LRB- cord-005453-4057qib7 9137 13 one one CD cord-005453-4057qib7 9137 14 PD PD NNP cord-005453-4057qib7 9137 15 , , , cord-005453-4057qib7 9137 16 one one CD cord-005453-4057qib7 9137 17 NRM NRM NNP cord-005453-4057qib7 9137 18 ) ) -RRB- cord-005453-4057qib7 9137 19 and and CC cord-005453-4057qib7 9137 20 3 3 CD cord-005453-4057qib7 9137 21 deaths death NNS cord-005453-4057qib7 9137 22 in in IN cord-005453-4057qib7 9137 23 the the DT cord-005453-4057qib7 9137 24 control control NN cord-005453-4057qib7 9137 25 group group NN cord-005453-4057qib7 9137 26 ( ( -LRB- cord-005453-4057qib7 9137 27 all all DT cord-005453-4057qib7 9137 28 PD PD NNP cord-005453-4057qib7 9137 29 ) ) -RRB- cord-005453-4057qib7 9137 30 . . . cord-005453-4057qib7 9138 1 Conclusions conclusion NNS cord-005453-4057qib7 9138 2 : : : cord-005453-4057qib7 9139 1 This this DT cord-005453-4057qib7 9139 2 observational observational JJ cord-005453-4057qib7 9139 3 study study NN cord-005453-4057qib7 9139 4 confirms confirm VBZ cord-005453-4057qib7 9139 5 the the DT cord-005453-4057qib7 9139 6 safety safety NN cord-005453-4057qib7 9139 7 and and CC cord-005453-4057qib7 9139 8 efficacy efficacy NN cord-005453-4057qib7 9139 9 of of IN cord-005453-4057qib7 9139 10 letermovir letermovir NNS cord-005453-4057qib7 9139 11 for for IN cord-005453-4057qib7 9139 12 the the DT cord-005453-4057qib7 9139 13 prophylaxis prophylaxis NN cord-005453-4057qib7 9139 14 of of IN cord-005453-4057qib7 9139 15 CMV CMV NNP cord-005453-4057qib7 9139 16 reactivation reactivation NN cord-005453-4057qib7 9139 17 in in IN cord-005453-4057qib7 9139 18 seropositive seropositive JJ cord-005453-4057qib7 9139 19 patients patient NNS cord-005453-4057qib7 9139 20 after after IN cord-005453-4057qib7 9139 21 alloHCT alloHCT NNP cord-005453-4057qib7 9139 22 in in IN cord-005453-4057qib7 9139 23 a a DT cord-005453-4057qib7 9139 24 real real JJ cord-005453-4057qib7 9139 25 - - HYPH cord-005453-4057qib7 9139 26 world world NN cord-005453-4057qib7 9139 27 setting setting NN cord-005453-4057qib7 9139 28 . . . cord-005453-4057qib7 9140 1 Our -PRON- PRP$ cord-005453-4057qib7 9140 2 results result NNS cord-005453-4057qib7 9140 3 are be VBP cord-005453-4057qib7 9140 4 in in IN cord-005453-4057qib7 9140 5 good good JJ cord-005453-4057qib7 9140 6 concordance concordance NN cord-005453-4057qib7 9140 7 with with IN cord-005453-4057qib7 9140 8 the the DT cord-005453-4057qib7 9140 9 phase phase NN cord-005453-4057qib7 9140 10 III iii CD cord-005453-4057qib7 9140 11 trial trial NN cord-005453-4057qib7 9140 12 . . . cord-005453-4057qib7 9141 1 Although although IN cord-005453-4057qib7 9141 2 letermovir letermovir NNS cord-005453-4057qib7 9141 3 appeared appear VBD cord-005453-4057qib7 9141 4 to to TO cord-005453-4057qib7 9141 5 reduce reduce VB cord-005453-4057qib7 9141 6 the the DT cord-005453-4057qib7 9141 7 need need NN cord-005453-4057qib7 9141 8 for for IN cord-005453-4057qib7 9141 9 therapeutic therapeutic JJ cord-005453-4057qib7 9141 10 valganciclovir valganciclovir NNS cord-005453-4057qib7 9141 11 and and CC cord-005453-4057qib7 9141 12 foscavir foscavir NNP cord-005453-4057qib7 9141 13 tremendously tremendously RB cord-005453-4057qib7 9141 14 , , , cord-005453-4057qib7 9141 15 larger large JJR cord-005453-4057qib7 9141 16 samples sample NNS cord-005453-4057qib7 9141 17 with with IN cord-005453-4057qib7 9141 18 longer long JJR cord-005453-4057qib7 9141 19 follow follow NN cord-005453-4057qib7 9141 20 - - HYPH cord-005453-4057qib7 9141 21 up up NN cord-005453-4057qib7 9141 22 are be VBP cord-005453-4057qib7 9141 23 needed need VBN cord-005453-4057qib7 9141 24 to to TO cord-005453-4057qib7 9141 25 assess assess VB cord-005453-4057qib7 9141 26 the the DT cord-005453-4057qib7 9141 27 impact impact NN cord-005453-4057qib7 9141 28 of of IN cord-005453-4057qib7 9141 29 letermovir letermovir NNP cord-005453-4057qib7 9141 30 prophylaxis prophylaxis NN cord-005453-4057qib7 9141 31 on on IN cord-005453-4057qib7 9141 32 non non JJ cord-005453-4057qib7 9141 33 - - JJ cord-005453-4057qib7 9141 34 relapse relapse JJ cord-005453-4057qib7 9141 35 and and CC cord-005453-4057qib7 9141 36 overall overall JJ cord-005453-4057qib7 9141 37 mortality mortality NN cord-005453-4057qib7 9141 38 as as RB cord-005453-4057qib7 9141 39 well well RB cord-005453-4057qib7 9141 40 as as IN cord-005453-4057qib7 9141 41 on on IN cord-005453-4057qib7 9141 42 resource resource NN cord-005453-4057qib7 9141 43 consumption consumption NN cord-005453-4057qib7 9141 44 . . . cord-005453-4057qib7 9142 1 Background background NN cord-005453-4057qib7 9142 2 : : : cord-005453-4057qib7 9143 1 CMV CMV NNP cord-005453-4057qib7 9143 2 viremia viremia NN cord-005453-4057qib7 9143 3 occurs occur VBZ cord-005453-4057qib7 9143 4 in in IN cord-005453-4057qib7 9143 5 40%-80 40%-80 CD cord-005453-4057qib7 9143 6 % % NN cord-005453-4057qib7 9143 7 of of IN cord-005453-4057qib7 9143 8 CMV CMV NNP cord-005453-4057qib7 9143 9 R R NNP cord-005453-4057qib7 9143 10 + + SYM cord-005453-4057qib7 9143 11 HCT hct NN cord-005453-4057qib7 9143 12 recipients recipient NNS cord-005453-4057qib7 9143 13 . . . cord-005453-4057qib7 9144 1 PET pet JJ cord-005453-4057qib7 9144 2 use use NN cord-005453-4057qib7 9144 3 has have VBZ cord-005453-4057qib7 9144 4 reduced reduce VBN cord-005453-4057qib7 9144 5 the the DT cord-005453-4057qib7 9144 6 risk risk NN cord-005453-4057qib7 9144 7 of of IN cord-005453-4057qib7 9144 8 CMV CMV NNP cord-005453-4057qib7 9144 9 end end NN cord-005453-4057qib7 9144 10 - - HYPH cord-005453-4057qib7 9144 11 organ organ NN cord-005453-4057qib7 9144 12 disease disease NN cord-005453-4057qib7 9144 13 ( ( -LRB- cord-005453-4057qib7 9144 14 EOD EOD NNP cord-005453-4057qib7 9144 15 ) ) -RRB- cord-005453-4057qib7 9144 16 and and CC cord-005453-4057qib7 9144 17 associated associate VBN cord-005453-4057qib7 9144 18 mortality mortality NN cord-005453-4057qib7 9144 19 ; ; : cord-005453-4057qib7 9144 20 However however RB cord-005453-4057qib7 9144 21 , , , cord-005453-4057qib7 9144 22 PET pet JJ cord-005453-4057qib7 9144 23 use use NN cord-005453-4057qib7 9144 24 may may MD cord-005453-4057qib7 9144 25 lead lead VB cord-005453-4057qib7 9144 26 to to IN cord-005453-4057qib7 9144 27 substantial substantial JJ cord-005453-4057qib7 9144 28 antiviral antiviral JJ cord-005453-4057qib7 9144 29 use use NN cord-005453-4057qib7 9144 30 and and CC cord-005453-4057qib7 9144 31 healthcare healthcare NN cord-005453-4057qib7 9144 32 resource resource NN cord-005453-4057qib7 9144 33 utilization utilization NN cord-005453-4057qib7 9144 34 . . . cord-005453-4057qib7 9145 1 Limited limited JJ cord-005453-4057qib7 9145 2 real real JJ cord-005453-4057qib7 9145 3 - - HYPH cord-005453-4057qib7 9145 4 world world NN cord-005453-4057qib7 9145 5 data datum NNS cord-005453-4057qib7 9145 6 are be VBP cord-005453-4057qib7 9145 7 available available JJ cord-005453-4057qib7 9145 8 on on IN cord-005453-4057qib7 9145 9 the the DT cord-005453-4057qib7 9145 10 outcomes outcome NNS cord-005453-4057qib7 9145 11 of of IN cord-005453-4057qib7 9145 12 PET pet NN cord-005453-4057qib7 9145 13 . . . cord-005453-4057qib7 9146 1 Therefore therefore RB cord-005453-4057qib7 9146 2 , , , cord-005453-4057qib7 9146 3 we -PRON- PRP cord-005453-4057qib7 9146 4 aimed aim VBD cord-005453-4057qib7 9146 5 to to TO cord-005453-4057qib7 9146 6 examine examine VB cord-005453-4057qib7 9146 7 CMV CMV NNP cord-005453-4057qib7 9146 8 outcomes outcome NNS cord-005453-4057qib7 9146 9 ( ( -LRB- cord-005453-4057qib7 9146 10 EOD EOD NNP cord-005453-4057qib7 9146 11 , , , cord-005453-4057qib7 9146 12 resistance resistance NN cord-005453-4057qib7 9146 13 ) ) -RRB- cord-005453-4057qib7 9146 14 , , , cord-005453-4057qib7 9146 15 CMV CMV NNP cord-005453-4057qib7 9146 16 - - HYPH cord-005453-4057qib7 9146 17 related relate VBN cord-005453-4057qib7 9146 18 mortality mortality NN cord-005453-4057qib7 9146 19 by by IN cord-005453-4057qib7 9146 20 Day day NN cord-005453-4057qib7 9146 21 ( ( -LRB- cord-005453-4057qib7 9146 22 D)180 D)180 NNP cord-005453-4057qib7 9146 23 and and CC cord-005453-4057qib7 9146 24 healthcare healthcare NN cord-005453-4057qib7 9146 25 resource resource NN cord-005453-4057qib7 9146 26 utilization utilization NN cord-005453-4057qib7 9146 27 between between IN cord-005453-4057qib7 9146 28 PET pet NN cord-005453-4057qib7 9146 29 and and CC cord-005453-4057qib7 9146 30 No no DT cord-005453-4057qib7 9146 31 - - HYPH cord-005453-4057qib7 9146 32 PET pet JJ cord-005453-4057qib7 9146 33 groups group NNS cord-005453-4057qib7 9146 34 among among IN cord-005453-4057qib7 9146 35 CMV CMV NNP cord-005453-4057qib7 9146 36 R+ r+ NN cord-005453-4057qib7 9146 37 recipients recipient NNS cord-005453-4057qib7 9146 38 undergoing undergo VBG cord-005453-4057qib7 9146 39 first first JJ cord-005453-4057qib7 9146 40 HCT HCT NNP cord-005453-4057qib7 9146 41 . . . cord-005453-4057qib7 9147 1 Methods method NNS cord-005453-4057qib7 9147 2 : : : cord-005453-4057qib7 9147 3 We -PRON- PRP cord-005453-4057qib7 9147 4 conducted conduct VBD cord-005453-4057qib7 9147 5 a a DT cord-005453-4057qib7 9147 6 retrospective retrospective JJ cord-005453-4057qib7 9147 7 cohort cohort NN cord-005453-4057qib7 9147 8 study study NN cord-005453-4057qib7 9147 9 of of IN cord-005453-4057qib7 9147 10 adults adult NNS cord-005453-4057qib7 9147 11 , , , cord-005453-4057qib7 9148 1 CMV CMV NNP cord-005453-4057qib7 9148 2 R+ r+ NN cord-005453-4057qib7 9148 3 recipients recipient NNS cord-005453-4057qib7 9148 4 of of IN cord-005453-4057qib7 9148 5 first first JJ cord-005453-4057qib7 9148 6 peripheral peripheral JJ cord-005453-4057qib7 9148 7 blood blood NN cord-005453-4057qib7 9148 8 or or CC cord-005453-4057qib7 9148 9 marrow marrow NN cord-005453-4057qib7 9148 10 allograft allograft NN cord-005453-4057qib7 9148 11 at at IN cord-005453-4057qib7 9148 12 MSKCC MSKCC NNS cord-005453-4057qib7 9148 13 identified identify VBN cord-005453-4057qib7 9148 14 from from IN cord-005453-4057qib7 9148 15 March March NNP cord-005453-4057qib7 9148 16 2013 2013 CD cord-005453-4057qib7 9148 17 through through IN cord-005453-4057qib7 9148 18 December December NNP cord-005453-4057qib7 9148 19 2017 2017 CD cord-005453-4057qib7 9148 20 . . . cord-005453-4057qib7 9149 1 Data datum NNS cord-005453-4057qib7 9149 2 was be VBD cord-005453-4057qib7 9149 3 extracted extract VBN cord-005453-4057qib7 9149 4 from from IN cord-005453-4057qib7 9149 5 electronic electronic JJ cord-005453-4057qib7 9149 6 medical medical JJ cord-005453-4057qib7 9149 7 records record NNS cord-005453-4057qib7 9149 8 and and CC cord-005453-4057qib7 9149 9 HCT hct NN cord-005453-4057qib7 9149 10 databases database NNS cord-005453-4057qib7 9149 11 . . . cord-005453-4057qib7 9150 1 CMV+ CMV+ NNP cord-005453-4057qib7 9150 2 recipients recipient NNS cord-005453-4057qib7 9150 3 were be VBD cord-005453-4057qib7 9150 4 monitored monitor VBN cord-005453-4057qib7 9150 5 weekly weekly RB cord-005453-4057qib7 9150 6 by by IN cord-005453-4057qib7 9150 7 quantitative quantitative JJ cord-005453-4057qib7 9150 8 PCR PCR NNP cord-005453-4057qib7 9150 9 assay assay NN cord-005453-4057qib7 9150 10 starting start VBG cord-005453-4057qib7 9150 11 on on IN cord-005453-4057qib7 9150 12 D14 D14 NNP cord-005453-4057qib7 9150 13 through through IN cord-005453-4057qib7 9150 14 D180 d180 ADD cord-005453-4057qib7 9150 15 post post NN cord-005453-4057qib7 9150 16 HCT hct NN cord-005453-4057qib7 9150 17 . . . cord-005453-4057qib7 9151 1 Use use NN cord-005453-4057qib7 9151 2 of of IN cord-005453-4057qib7 9151 3 antiviral antiviral JJ cord-005453-4057qib7 9151 4 therapy therapy NN cord-005453-4057qib7 9151 5 for for IN cord-005453-4057qib7 9151 6 CMV CMV NNP cord-005453-4057qib7 9151 7 viremia viremia NN cord-005453-4057qib7 9151 8 defined define VBD cord-005453-4057qib7 9151 9 PET PET NNP cord-005453-4057qib7 9151 10 . . . cord-005453-4057qib7 9152 1 High high JJ cord-005453-4057qib7 9152 2 CMV CMV NNP cord-005453-4057qib7 9152 3 risk risk NN cord-005453-4057qib7 9152 4 ( ( -LRB- cord-005453-4057qib7 9152 5 HR HR NNP cord-005453-4057qib7 9152 6 ) ) -RRB- cord-005453-4057qib7 9152 7 comprised comprise VBD cord-005453-4057qib7 9152 8 T t NN cord-005453-4057qib7 9152 9 - - HYPH cord-005453-4057qib7 9152 10 cell cell NN cord-005453-4057qib7 9152 11 depleted deplete VBN cord-005453-4057qib7 9153 1 ( ( -LRB- cord-005453-4057qib7 9153 2 TCD TCD NNP cord-005453-4057qib7 9153 3 ) ) -RRB- cord-005453-4057qib7 9153 4 HCT hct NN cord-005453-4057qib7 9153 5 by by IN cord-005453-4057qib7 9153 6 CD34 CD34 NNP cord-005453-4057qib7 9154 1 + + CC cord-005453-4057qib7 9155 1 -selection -selection NN cord-005453-4057qib7 9156 1 regardless regardless RB cord-005453-4057qib7 9156 2 of of IN cord-005453-4057qib7 9156 3 donor donor NN cord-005453-4057qib7 9156 4 HLA HLA NNP cord-005453-4057qib7 9156 5 match match NN cord-005453-4057qib7 9156 6 or or CC cord-005453-4057qib7 9156 7 conventional conventional JJ cord-005453-4057qib7 9156 8 HCT hct NN cord-005453-4057qib7 9156 9 from from IN cord-005453-4057qib7 9156 10 mismatched mismatched JJ cord-005453-4057qib7 9156 11 or or CC cord-005453-4057qib7 9156 12 haploidentical haploidentical JJ cord-005453-4057qib7 9156 13 donors donor NNS cord-005453-4057qib7 9156 14 ; ; : cord-005453-4057qib7 9156 15 Low low JJ cord-005453-4057qib7 9156 16 risk risk NN cord-005453-4057qib7 9156 17 ( ( -LRB- cord-005453-4057qib7 9156 18 LR LR NNP cord-005453-4057qib7 9156 19 ) ) -RRB- cord-005453-4057qib7 9156 20 included include VBD cord-005453-4057qib7 9156 21 conventional conventional JJ cord-005453-4057qib7 9156 22 HCT hct NN cord-005453-4057qib7 9156 23 from from IN cord-005453-4057qib7 9156 24 matched match VBN cord-005453-4057qib7 9156 25 related related JJ cord-005453-4057qib7 9156 26 donors donor NNS cord-005453-4057qib7 9156 27 . . . cord-005453-4057qib7 9157 1 CMV CMV NNP cord-005453-4057qib7 9157 2 EOD EOD NNP cord-005453-4057qib7 9157 3 was be VBD cord-005453-4057qib7 9157 4 scored score VBN cord-005453-4057qib7 9157 5 by by IN cord-005453-4057qib7 9157 6 standard standard JJ cord-005453-4057qib7 9157 7 criteria criterion NNS cord-005453-4057qib7 9157 8 . . . cord-005453-4057qib7 9158 1 CMV CMV NNP cord-005453-4057qib7 9158 2 resistance resistance NN cord-005453-4057qib7 9158 3 mutations mutation NNS cord-005453-4057qib7 9158 4 were be VBD cord-005453-4057qib7 9158 5 confirmed confirm VBN cord-005453-4057qib7 9158 6 by by IN cord-005453-4057qib7 9158 7 sequencing sequence VBG cord-005453-4057qib7 9158 8 ( ( -LRB- cord-005453-4057qib7 9158 9 Viracor Viracor NNP cord-005453-4057qib7 9158 10 - - HYPH cord-005453-4057qib7 9158 11 Eurofins Eurofins NNP cord-005453-4057qib7 9158 12 ) ) -RRB- cord-005453-4057qib7 9158 13 . . . cord-005453-4057qib7 9159 1 Length length NN cord-005453-4057qib7 9159 2 of of IN cord-005453-4057qib7 9159 3 stay stay NN cord-005453-4057qib7 9159 4 ( ( -LRB- cord-005453-4057qib7 9159 5 LOS LOS NNP cord-005453-4057qib7 9159 6 ) ) -RRB- cord-005453-4057qib7 9159 7 for for IN cord-005453-4057qib7 9159 8 HCT hct NN cord-005453-4057qib7 9159 9 admissions admission NNS cord-005453-4057qib7 9159 10 and and CC cord-005453-4057qib7 9159 11 readmissions readmission NNS cord-005453-4057qib7 9159 12 were be VBD cord-005453-4057qib7 9159 13 identified identify VBN cord-005453-4057qib7 9159 14 through through IN cord-005453-4057qib7 9159 15 D180 D180 NNPS cord-005453-4057qib7 9159 16 . . . cord-005453-4057qib7 9160 1 Stratified stratified JJ cord-005453-4057qib7 9160 2 analyses analysis NNS cord-005453-4057qib7 9160 3 were be VBD cord-005453-4057qib7 9160 4 performed perform VBN cord-005453-4057qib7 9160 5 to to TO cord-005453-4057qib7 9160 6 examine examine VB cord-005453-4057qib7 9160 7 outcomes outcome NNS cord-005453-4057qib7 9160 8 by by IN cord-005453-4057qib7 9160 9 PET pet JJ cord-005453-4057qib7 9160 10 use use NN cord-005453-4057qib7 9160 11 and and CC cord-005453-4057qib7 9160 12 CMV CMV NNP cord-005453-4057qib7 9160 13 risk risk NN cord-005453-4057qib7 9160 14 . . . cord-005453-4057qib7 9161 1 Background background NN cord-005453-4057qib7 9161 2 : : : cord-005453-4057qib7 9162 1 In in IN cord-005453-4057qib7 9162 2 a a DT cord-005453-4057qib7 9162 3 Phase Phase NNP cord-005453-4057qib7 9162 4 III iii CD cord-005453-4057qib7 9162 5 randomized randomized JJ cord-005453-4057qib7 9162 6 , , , cord-005453-4057qib7 9162 7 double double JJ cord-005453-4057qib7 9162 8 - - HYPH cord-005453-4057qib7 9162 9 blind blind JJ cord-005453-4057qib7 9162 10 , , , cord-005453-4057qib7 9162 11 placebo placebo NN cord-005453-4057qib7 9162 12 - - HYPH cord-005453-4057qib7 9162 13 controlled control VBN cord-005453-4057qib7 9162 14 study study NN cord-005453-4057qib7 9162 15 of of IN cord-005453-4057qib7 9162 16 CMV CMV NNP cord-005453-4057qib7 9162 17 - - HYPH cord-005453-4057qib7 9162 18 seropositive seropositive JJ cord-005453-4057qib7 9162 19 post post JJ cord-005453-4057qib7 9162 20 - - JJ cord-005453-4057qib7 9162 21 HSCT hsct JJ cord-005453-4057qib7 9162 22 recipients recipient NNS cord-005453-4057qib7 9162 23 , , , cord-005453-4057qib7 9162 24 letermovir letermovir NNP cord-005453-4057qib7 9162 25 prophylaxis prophylaxis NN cord-005453-4057qib7 9162 26 significantly significantly RB cord-005453-4057qib7 9162 27 reduced reduce VBD cord-005453-4057qib7 9162 28 the the DT cord-005453-4057qib7 9162 29 incidence incidence NN cord-005453-4057qib7 9162 30 of of IN cord-005453-4057qib7 9162 31 clinically clinically RB cord-005453-4057qib7 9162 32 significant significant JJ cord-005453-4057qib7 9162 33 CMV CMV NNP cord-005453-4057qib7 9162 34 infection infection NN cord-005453-4057qib7 9162 35 through through IN cord-005453-4057qib7 9162 36 week week NN cord-005453-4057qib7 9162 37 24 24 CD cord-005453-4057qib7 9162 38 . . . cord-005453-4057qib7 9163 1 The the DT cord-005453-4057qib7 9163 2 objective objective NN cord-005453-4057qib7 9163 3 of of IN cord-005453-4057qib7 9163 4 this this DT cord-005453-4057qib7 9163 5 research research NN cord-005453-4057qib7 9163 6 was be VBD cord-005453-4057qib7 9163 7 to to TO cord-005453-4057qib7 9163 8 assess assess VB cord-005453-4057qib7 9163 9 the the DT cord-005453-4057qib7 9163 10 impact impact NN cord-005453-4057qib7 9163 11 of of IN cord-005453-4057qib7 9163 12 CMV CMV NNP cord-005453-4057qib7 9163 13 prophylaxis prophylaxis NN cord-005453-4057qib7 9163 14 on on IN cord-005453-4057qib7 9163 15 rates rate NNS cord-005453-4057qib7 9163 16 of of IN cord-005453-4057qib7 9163 17 rehospitalization rehospitalization NN cord-005453-4057qib7 9163 18 in in IN cord-005453-4057qib7 9163 19 adult adult NN cord-005453-4057qib7 9163 20 CMV CMV NNP cord-005453-4057qib7 9163 21 seropositive seropositive JJ cord-005453-4057qib7 9163 22 allogeneic allogeneic VBD cord-005453-4057qib7 9163 23 HSCT HSCT NNP cord-005453-4057qib7 9163 24 recipients recipient NNS cord-005453-4057qib7 9163 25 from from IN cord-005453-4057qib7 9163 26 the the DT cord-005453-4057qib7 9163 27 letermovir letermovir NNS cord-005453-4057qib7 9163 28 phase phase NN cord-005453-4057qib7 9163 29 3 3 CD cord-005453-4057qib7 9163 30 clinical clinical JJ cord-005453-4057qib7 9163 31 trial trial NN cord-005453-4057qib7 9163 32 . . . cord-005453-4057qib7 9164 1 Methods method NNS cord-005453-4057qib7 9164 2 : : : cord-005453-4057qib7 9165 1 Rehospitalization rehospitalization NN cord-005453-4057qib7 9165 2 was be VBD cord-005453-4057qib7 9165 3 recorded record VBN cord-005453-4057qib7 9165 4 as as IN cord-005453-4057qib7 9165 5 an an DT cord-005453-4057qib7 9165 6 exploratory exploratory JJ cord-005453-4057qib7 9165 7 endpoint endpoint NN cord-005453-4057qib7 9165 8 in in IN cord-005453-4057qib7 9165 9 the the DT cord-005453-4057qib7 9165 10 clinical clinical JJ cord-005453-4057qib7 9165 11 trial trial NN cord-005453-4057qib7 9165 12 at at IN cord-005453-4057qib7 9165 13 end end NN cord-005453-4057qib7 9165 14 of of IN cord-005453-4057qib7 9165 15 treatment treatment NN cord-005453-4057qib7 9165 16 ( ( -LRB- cord-005453-4057qib7 9165 17 Week14 Week14 NNP cord-005453-4057qib7 9165 18 ) ) -RRB- cord-005453-4057qib7 9165 19 , , , cord-005453-4057qib7 9165 20 time time NN cord-005453-4057qib7 9165 21 of of IN cord-005453-4057qib7 9165 22 primary primary JJ cord-005453-4057qib7 9165 23 endpoint endpoint NN cord-005453-4057qib7 9165 24 ( ( -LRB- cord-005453-4057qib7 9165 25 Week24 week24 NN cord-005453-4057qib7 9165 26 ) ) -RRB- cord-005453-4057qib7 9165 27 and and CC cord-005453-4057qib7 9165 28 through through IN cord-005453-4057qib7 9165 29 an an DT cord-005453-4057qib7 9165 30 extended extended JJ cord-005453-4057qib7 9165 31 follow follow NN cord-005453-4057qib7 9165 32 - - HYPH cord-005453-4057qib7 9165 33 up up NN cord-005453-4057qib7 9165 34 period period NN cord-005453-4057qib7 9165 35 ( ( -LRB- cord-005453-4057qib7 9165 36 Week48 week48 NN cord-005453-4057qib7 9165 37 ) ) -RRB- cord-005453-4057qib7 9165 38 . . . cord-005453-4057qib7 9166 1 CMV CMV NNP cord-005453-4057qib7 9166 2 - - HYPH cord-005453-4057qib7 9166 3 related relate VBN cord-005453-4057qib7 9166 4 rehospitalization rehospitalization NN cord-005453-4057qib7 9166 5 was be VBD cord-005453-4057qib7 9166 6 assessed assess VBN cord-005453-4057qib7 9166 7 in in IN cord-005453-4057qib7 9166 8 the the DT cord-005453-4057qib7 9166 9 trial trial NN cord-005453-4057qib7 9166 10 . . . cord-005453-4057qib7 9167 1 Prespecified prespecified JJ cord-005453-4057qib7 9167 2 analyses analysis NNS cord-005453-4057qib7 9167 3 describe describe VBP cord-005453-4057qib7 9167 4 the the DT cord-005453-4057qib7 9167 5 observed observed JJ cord-005453-4057qib7 9167 6 rates rate NNS cord-005453-4057qib7 9167 7 of of IN cord-005453-4057qib7 9167 8 rehospitalization rehospitalization NN cord-005453-4057qib7 9167 9 for for IN cord-005453-4057qib7 9167 10 the the DT cord-005453-4057qib7 9167 11 letermovir letermovir NNS cord-005453-4057qib7 9167 12 and and CC cord-005453-4057qib7 9167 13 placebo placebo NN cord-005453-4057qib7 9167 14 groups group NNS cord-005453-4057qib7 9167 15 at at IN cord-005453-4057qib7 9167 16 the the DT cord-005453-4057qib7 9167 17 specified specified JJ cord-005453-4057qib7 9167 18 times time NNS cord-005453-4057qib7 9167 19 . . . cord-005453-4057qib7 9168 1 Fine fine JJ cord-005453-4057qib7 9168 2 - - HYPH cord-005453-4057qib7 9168 3 Gray gray JJ cord-005453-4057qib7 9168 4 cumulative cumulative JJ cord-005453-4057qib7 9168 5 incidence incidence NN cord-005453-4057qib7 9168 6 function(CIF function(cif CD cord-005453-4057qib7 9168 7 ) ) -RRB- cord-005453-4057qib7 9169 1 regression regression NN cord-005453-4057qib7 9169 2 models model NNS cord-005453-4057qib7 9169 3 were be VBD cord-005453-4057qib7 9169 4 used use VBN cord-005453-4057qib7 9169 5 to to TO cord-005453-4057qib7 9169 6 explore explore VB cord-005453-4057qib7 9169 7 the the DT cord-005453-4057qib7 9169 8 rate rate NN cord-005453-4057qib7 9169 9 of of IN cord-005453-4057qib7 9169 10 all all DT cord-005453-4057qib7 9169 11 - - HYPH cord-005453-4057qib7 9169 12 cause cause NN cord-005453-4057qib7 9169 13 , , , cord-005453-4057qib7 9169 14 and and CC cord-005453-4057qib7 9169 15 CMV CMV NNP cord-005453-4057qib7 9169 16 - - HYPH cord-005453-4057qib7 9169 17 related relate VBN cord-005453-4057qib7 9169 18 rehospitalization rehospitalization NN cord-005453-4057qib7 9169 19 accounting accounting NN cord-005453-4057qib7 9169 20 for for IN cord-005453-4057qib7 9169 21 the the DT cord-005453-4057qib7 9169 22 competing compete VBG cord-005453-4057qib7 9169 23 risk risk NN cord-005453-4057qib7 9169 24 of of IN cord-005453-4057qib7 9169 25 mortality mortality NN cord-005453-4057qib7 9169 26 . . . cord-005453-4057qib7 9170 1 A a DT cord-005453-4057qib7 9170 2 multiple multiple JJ cord-005453-4057qib7 9170 3 linear linear JJ cord-005453-4057qib7 9170 4 regression regression NN cord-005453-4057qib7 9170 5 model model NN cord-005453-4057qib7 9170 6 was be VBD cord-005453-4057qib7 9170 7 used use VBN cord-005453-4057qib7 9170 8 to to TO cord-005453-4057qib7 9170 9 describe describe VB cord-005453-4057qib7 9170 10 the the DT cord-005453-4057qib7 9170 11 cumulative cumulative JJ cord-005453-4057qib7 9170 12 length length NN cord-005453-4057qib7 9170 13 of of IN cord-005453-4057qib7 9170 14 stay stay NN cord-005453-4057qib7 9170 15 ( ( -LRB- cord-005453-4057qib7 9170 16 LOS LOS NNP cord-005453-4057qib7 9170 17 ) ) -RRB- cord-005453-4057qib7 9170 18 for for IN cord-005453-4057qib7 9170 19 all all DT cord-005453-4057qib7 9170 20 - - HYPH cord-005453-4057qib7 9170 21 cause cause NN cord-005453-4057qib7 9170 22 rehospitalizations rehospitalization NNS cord-005453-4057qib7 9170 23 that that WDT cord-005453-4057qib7 9170 24 occurred occur VBD cord-005453-4057qib7 9170 25 through through IN cord-005453-4057qib7 9170 26 Week48 week48 CD cord-005453-4057qib7 9171 1 ( ( -LRB- cord-005453-4057qib7 9171 2 excluding exclude VBG cord-005453-4057qib7 9171 3 time time NN cord-005453-4057qib7 9171 4 of of IN cord-005453-4057qib7 9171 5 initial initial JJ cord-005453-4057qib7 9171 6 transplant transplant NN cord-005453-4057qib7 9171 7 stay stay NN cord-005453-4057qib7 9171 8 ) ) -RRB- cord-005453-4057qib7 9171 9 . . . cord-005453-4057qib7 9172 1 Results result NNS cord-005453-4057qib7 9172 2 : : : cord-005453-4057qib7 9173 1 Observed observed JJ cord-005453-4057qib7 9173 2 rates rate NNS cord-005453-4057qib7 9173 3 of of IN cord-005453-4057qib7 9173 4 all all DT cord-005453-4057qib7 9173 5 - - HYPH cord-005453-4057qib7 9173 6 cause cause NN cord-005453-4057qib7 9173 7 rehospitalization rehospitalization NN cord-005453-4057qib7 9173 8 were be VBD cord-005453-4057qib7 9173 9 lower low JJR cord-005453-4057qib7 9173 10 for for IN cord-005453-4057qib7 9173 11 the the DT cord-005453-4057qib7 9173 12 letermovir letermovir NNP cord-005453-4057qib7 9173 13 group group NN cord-005453-4057qib7 9173 14 compared compare VBN cord-005453-4057qib7 9173 15 to to IN cord-005453-4057qib7 9173 16 placebo placebo NN cord-005453-4057qib7 9173 17 at at IN cord-005453-4057qib7 9173 18 end end NN cord-005453-4057qib7 9173 19 of of IN cord-005453-4057qib7 9173 20 treatment treatment NN cord-005453-4057qib7 9174 1 ( ( -LRB- cord-005453-4057qib7 9174 2 36.6%vs.47 36.6%vs.47 CD cord-005453-4057qib7 9174 3 Conclusions Conclusions NNPS cord-005453-4057qib7 9174 4 : : : cord-005453-4057qib7 9175 1 Letermovir Letermovir NNP cord-005453-4057qib7 9175 2 was be VBD cord-005453-4057qib7 9175 3 shown show VBN cord-005453-4057qib7 9175 4 to to TO cord-005453-4057qib7 9175 5 significantly significantly RB cord-005453-4057qib7 9175 6 reduce reduce VB cord-005453-4057qib7 9175 7 the the DT cord-005453-4057qib7 9175 8 rate rate NN cord-005453-4057qib7 9175 9 of of IN cord-005453-4057qib7 9175 10 clinically clinically RB cord-005453-4057qib7 9175 11 significant significant JJ cord-005453-4057qib7 9175 12 CMV CMV NNP cord-005453-4057qib7 9175 13 infection infection NN cord-005453-4057qib7 9175 14 in in IN cord-005453-4057qib7 9175 15 a a DT cord-005453-4057qib7 9175 16 placebo placebo NN cord-005453-4057qib7 9175 17 - - HYPH cord-005453-4057qib7 9175 18 controlled control VBN cord-005453-4057qib7 9175 19 randomized randomized JJ cord-005453-4057qib7 9175 20 clinical clinical JJ cord-005453-4057qib7 9175 21 trial trial NN cord-005453-4057qib7 9175 22 . . . cord-005453-4057qib7 9176 1 These these DT cord-005453-4057qib7 9176 2 analyses analysis NNS cord-005453-4057qib7 9176 3 suggest suggest VBP cord-005453-4057qib7 9176 4 that that IN cord-005453-4057qib7 9176 5 there there EX cord-005453-4057qib7 9176 6 is be VBZ cord-005453-4057qib7 9176 7 also also RB cord-005453-4057qib7 9176 8 a a DT cord-005453-4057qib7 9176 9 reduction reduction NN cord-005453-4057qib7 9176 10 in in IN cord-005453-4057qib7 9176 11 the the DT cord-005453-4057qib7 9176 12 rate rate NN cord-005453-4057qib7 9176 13 and and CC cord-005453-4057qib7 9176 14 cumulative cumulative JJ cord-005453-4057qib7 9176 15 days day NNS cord-005453-4057qib7 9176 16 of of IN cord-005453-4057qib7 9176 17 rehospitalization rehospitalization NN cord-005453-4057qib7 9176 18 . . . cord-005453-4057qib7 9177 1 This this DT cord-005453-4057qib7 9177 2 trial trial NN cord-005453-4057qib7 9177 3 was be VBD cord-005453-4057qib7 9177 4 not not RB cord-005453-4057qib7 9177 5 sufficiently sufficiently RB cord-005453-4057qib7 9177 6 powered powered JJ cord-005453-4057qib7 9177 7 to to TO cord-005453-4057qib7 9177 8 detect detect VB cord-005453-4057qib7 9177 9 differences difference NNS cord-005453-4057qib7 9177 10 in in IN cord-005453-4057qib7 9177 11 this this DT cord-005453-4057qib7 9177 12 exploratory exploratory JJ cord-005453-4057qib7 9177 13 endpoint endpoint NN cord-005453-4057qib7 9177 14 . . . cord-005453-4057qib7 9178 1 Nonetheless nonetheless RB cord-005453-4057qib7 9178 2 , , , cord-005453-4057qib7 9178 3 these these DT cord-005453-4057qib7 9178 4 data datum NNS cord-005453-4057qib7 9178 5 provide provide VBP cord-005453-4057qib7 9178 6 valuable valuable JJ cord-005453-4057qib7 9178 7 insights insight NNS cord-005453-4057qib7 9178 8 into into IN cord-005453-4057qib7 9178 9 the the DT cord-005453-4057qib7 9178 10 economic economic JJ cord-005453-4057qib7 9178 11 burden burden NN cord-005453-4057qib7 9178 12 of of IN cord-005453-4057qib7 9178 13 CMV CMV NNP cord-005453-4057qib7 9178 14 . . . cord-005453-4057qib7 9179 1 Real real JJ cord-005453-4057qib7 9179 2 world world NN cord-005453-4057qib7 9179 3 data datum NNS cord-005453-4057qib7 9179 4 and and CC cord-005453-4057qib7 9179 5 findings finding NNS cord-005453-4057qib7 9179 6 from from IN cord-005453-4057qib7 9179 7 future future JJ cord-005453-4057qib7 9179 8 clinical clinical JJ cord-005453-4057qib7 9179 9 trials trial NNS cord-005453-4057qib7 9179 10 are be VBP cord-005453-4057qib7 9179 11 needed need VBN cord-005453-4057qib7 9179 12 to to TO cord-005453-4057qib7 9179 13 better better RB cord-005453-4057qib7 9179 14 understand understand VB cord-005453-4057qib7 9179 15 the the DT cord-005453-4057qib7 9179 16 nature nature NN cord-005453-4057qib7 9179 17 of of IN cord-005453-4057qib7 9179 18 the the DT cord-005453-4057qib7 9179 19 association association NN cord-005453-4057qib7 9179 20 between between IN cord-005453-4057qib7 9179 21 CMV CMV NNP cord-005453-4057qib7 9179 22 and and CC cord-005453-4057qib7 9179 23 rehospitalizations rehospitalization NNS cord-005453-4057qib7 9179 24 . . . cord-005453-4057qib7 9180 1 Clinical clinical JJ cord-005453-4057qib7 9180 2 Methods method NNS cord-005453-4057qib7 9180 3 : : : cord-005453-4057qib7 9181 1 All all DT cord-005453-4057qib7 9181 2 consecutive consecutive JJ cord-005453-4057qib7 9181 3 patients patient NNS cord-005453-4057qib7 9181 4 with with IN cord-005453-4057qib7 9181 5 hematologic hematologic JJ cord-005453-4057qib7 9181 6 disorders disorder NNS cord-005453-4057qib7 9181 7 who who WP cord-005453-4057qib7 9181 8 received receive VBD cord-005453-4057qib7 9181 9 HSCT HSCT NNP cord-005453-4057qib7 9181 10 at at IN cord-005453-4057qib7 9181 11 our -PRON- PRP$ cord-005453-4057qib7 9181 12 Center Center NNP cord-005453-4057qib7 9181 13 between between IN cord-005453-4057qib7 9181 14 January January NNP cord-005453-4057qib7 9181 15 2013 2013 CD cord-005453-4057qib7 9181 16 and and CC cord-005453-4057qib7 9181 17 August August NNP cord-005453-4057qib7 9181 18 2018 2018 CD cord-005453-4057qib7 9181 19 were be VBD cord-005453-4057qib7 9181 20 included include VBN cord-005453-4057qib7 9181 21 . . . cord-005453-4057qib7 9182 1 Among among IN cord-005453-4057qib7 9182 2 the the DT cord-005453-4057qib7 9182 3 278 278 CD cord-005453-4057qib7 9182 4 evaluable evaluable JJ cord-005453-4057qib7 9182 5 patients patient NNS cord-005453-4057qib7 9182 6 , , , cord-005453-4057qib7 9182 7 172 172 CD cord-005453-4057qib7 9182 8 received receive VBD cord-005453-4057qib7 9182 9 levofloxacin levofloxacin NNS cord-005453-4057qib7 9182 10 as as IN cord-005453-4057qib7 9182 11 antibacterial antibacterial JJ cord-005453-4057qib7 9182 12 prophylaxis prophylaxis NN cord-005453-4057qib7 9182 13 ( ( -LRB- cord-005453-4057qib7 9182 14 group group NN cord-005453-4057qib7 9182 15 A A NNP cord-005453-4057qib7 9182 16 ) ) -RRB- cord-005453-4057qib7 9182 17 while while IN cord-005453-4057qib7 9182 18 106 106 CD cord-005453-4057qib7 9182 19 did do VBD cord-005453-4057qib7 9182 20 not not RB cord-005453-4057qib7 9182 21 receive receive VB cord-005453-4057qib7 9182 22 any any DT cord-005453-4057qib7 9182 23 FQ FQ NNP cord-005453-4057qib7 9182 24 prophylaxis prophylaxis NN cord-005453-4057qib7 9182 25 ( ( -LRB- cord-005453-4057qib7 9182 26 group group NN cord-005453-4057qib7 9182 27 B B NNP cord-005453-4057qib7 9182 28 ) ) -RRB- cord-005453-4057qib7 9182 29 . . . cord-005453-4057qib7 9183 1 Baseline baseline JJ cord-005453-4057qib7 9183 2 characteristics characteristic NNS cord-005453-4057qib7 9183 3 were be VBD cord-005453-4057qib7 9183 4 similar similar JJ cord-005453-4057qib7 9183 5 in in IN cord-005453-4057qib7 9183 6 the the DT cord-005453-4057qib7 9183 7 two two CD cord-005453-4057qib7 9183 8 groups group NNS cord-005453-4057qib7 9183 9 , , , cord-005453-4057qib7 9183 10 except except IN cord-005453-4057qib7 9183 11 for for IN cord-005453-4057qib7 9183 12 the the DT cord-005453-4057qib7 9183 13 number number NN cord-005453-4057qib7 9183 14 of of IN cord-005453-4057qib7 9183 15 patients patient NNS cord-005453-4057qib7 9183 16 with with IN cord-005453-4057qib7 9183 17 advanced advanced JJ cord-005453-4057qib7 9183 18 disease disease NN cord-005453-4057qib7 9183 19 ( ( -LRB- cord-005453-4057qib7 9183 20 34 34 CD cord-005453-4057qib7 9183 21 % % NN cord-005453-4057qib7 9183 22 in in IN cord-005453-4057qib7 9183 23 group group NN cord-005453-4057qib7 9183 24 A a NN cord-005453-4057qib7 9183 25 and and CC cord-005453-4057qib7 9183 26 47 47 CD cord-005453-4057qib7 9183 27 % % NN cord-005453-4057qib7 9183 28 in in IN cord-005453-4057qib7 9183 29 group group NN cord-005453-4057qib7 9183 30 B B NNP cord-005453-4057qib7 9183 31 , , , cord-005453-4057qib7 9183 32 p p NN cord-005453-4057qib7 9183 33 0,042 0,042 CD cord-005453-4057qib7 9183 34 ) ) -RRB- cord-005453-4057qib7 9183 35 . . . cord-005453-4057qib7 9184 1 Median median JJ cord-005453-4057qib7 9184 2 duration duration NN cord-005453-4057qib7 9184 3 of of IN cord-005453-4057qib7 9184 4 neutropenia neutropenia NN cord-005453-4057qib7 9184 5 was be VBD cord-005453-4057qib7 9184 6 16 16 CD cord-005453-4057qib7 9184 7 days day NNS cord-005453-4057qib7 9185 1 ( ( -LRB- cord-005453-4057qib7 9185 2 range range NNP cord-005453-4057qib7 9185 3 9 9 CD cord-005453-4057qib7 9185 4 - - SYM cord-005453-4057qib7 9185 5 44 44 CD cord-005453-4057qib7 9185 6 ) ) -RRB- cord-005453-4057qib7 9185 7 in in IN cord-005453-4057qib7 9185 8 group group NN cord-005453-4057qib7 9185 9 A a NN cord-005453-4057qib7 9185 10 and and CC cord-005453-4057qib7 9185 11 14 14 CD cord-005453-4057qib7 9185 12 days day NNS cord-005453-4057qib7 9185 13 ( ( -LRB- cord-005453-4057qib7 9185 14 range range NNP cord-005453-4057qib7 9185 15 4 4 CD cord-005453-4057qib7 9185 16 - - SYM cord-005453-4057qib7 9185 17 31 31 CD cord-005453-4057qib7 9185 18 ) ) -RRB- cord-005453-4057qib7 9185 19 in in IN cord-005453-4057qib7 9185 20 group group NN cord-005453-4057qib7 9185 21 B. B. NNP cord-005453-4057qib7 9185 22 A a DT cord-005453-4057qib7 9185 23 positive positive JJ cord-005453-4057qib7 9185 24 rectal rectal JJ cord-005453-4057qib7 9185 25 swab swab NN cord-005453-4057qib7 9185 26 for for IN cord-005453-4057qib7 9185 27 Carbapenem Carbapenem NNP cord-005453-4057qib7 9185 28 - - HYPH cord-005453-4057qib7 9185 29 resistant resistant JJ cord-005453-4057qib7 9185 30 Enterobacteriaceae Enterobacteriaceae NNP cord-005453-4057qib7 9185 31 ( ( -LRB- cord-005453-4057qib7 9185 32 CRE CRE NNP cord-005453-4057qib7 9185 33 ) ) -RRB- cord-005453-4057qib7 9185 34 was be VBD cord-005453-4057qib7 9185 35 detected detect VBN cord-005453-4057qib7 9185 36 in in IN cord-005453-4057qib7 9185 37 3 3 CD cord-005453-4057qib7 9185 38 patients patient NNS cord-005453-4057qib7 9185 39 in in IN cord-005453-4057qib7 9185 40 group group NN cord-005453-4057qib7 9185 41 A a NN cord-005453-4057qib7 9185 42 and and CC cord-005453-4057qib7 9185 43 8 8 CD cord-005453-4057qib7 9185 44 patients patient NNS cord-005453-4057qib7 9185 45 in in IN cord-005453-4057qib7 9185 46 group group NN cord-005453-4057qib7 9185 47 B. B. NNP cord-005453-4057qib7 9185 48 Results Results NNP cord-005453-4057qib7 9185 49 : : : cord-005453-4057qib7 9186 1 Overall overall RB cord-005453-4057qib7 9186 2 , , , cord-005453-4057qib7 9186 3 BSI BSI NNP cord-005453-4057qib7 9186 4 was be VBD cord-005453-4057qib7 9186 5 detected detect VBN cord-005453-4057qib7 9186 6 in in IN cord-005453-4057qib7 9186 7 58 58 CD cord-005453-4057qib7 9186 8 patients patient NNS cord-005453-4057qib7 9186 9 ( ( -LRB- cord-005453-4057qib7 9186 10 20,9 20,9 CD cord-005453-4057qib7 9186 11 % % NN cord-005453-4057qib7 9186 12 ) ) -RRB- cord-005453-4057qib7 9186 13 , , , cord-005453-4057qib7 9186 14 29 29 CD cord-005453-4057qib7 9186 15 ( ( -LRB- cord-005453-4057qib7 9186 16 16,9 16,9 CD cord-005453-4057qib7 9186 17 % % NN cord-005453-4057qib7 9186 18 ) ) -RRB- cord-005453-4057qib7 9186 19 in in IN cord-005453-4057qib7 9186 20 group group NN cord-005453-4057qib7 9186 21 A A NNP cord-005453-4057qib7 9186 22 and and CC cord-005453-4057qib7 9186 23 29 29 CD cord-005453-4057qib7 9186 24 ( ( -LRB- cord-005453-4057qib7 9186 25 27,4 27,4 CD cord-005453-4057qib7 9186 26 % % NN cord-005453-4057qib7 9186 27 ) ) -RRB- cord-005453-4057qib7 9186 28 in in IN cord-005453-4057qib7 9186 29 group group NN cord-005453-4057qib7 9186 30 B B NNP cord-005453-4057qib7 9186 31 ( ( -LRB- cord-005453-4057qib7 9186 32 p=0,048 p=0,048 NNP cord-005453-4057qib7 9186 33 ) ) -RRB- cord-005453-4057qib7 9186 34 . . . cord-005453-4057qib7 9187 1 The the DT cord-005453-4057qib7 9187 2 median median JJ cord-005453-4057qib7 9187 3 onset onset NN cord-005453-4057qib7 9187 4 of of IN cord-005453-4057qib7 9187 5 BSI BSI NNP cord-005453-4057qib7 9187 6 was be VBD cord-005453-4057qib7 9187 7 8 8 CD cord-005453-4057qib7 9187 8 days day NNS cord-005453-4057qib7 9187 9 post post NN cord-005453-4057qib7 9187 10 transplant transplant NN cord-005453-4057qib7 9187 11 ( ( -LRB- cord-005453-4057qib7 9187 12 range range NN cord-005453-4057qib7 9187 13 0 0 CD cord-005453-4057qib7 9187 14 - - HYPH cord-005453-4057qib7 9187 15 28 28 CD cord-005453-4057qib7 9187 16 ) ) -RRB- cord-005453-4057qib7 9187 17 , , , cord-005453-4057qib7 9187 18 without without IN cord-005453-4057qib7 9187 19 significant significant JJ cord-005453-4057qib7 9187 20 differences difference NNS cord-005453-4057qib7 9187 21 between between IN cord-005453-4057qib7 9187 22 the the DT cord-005453-4057qib7 9187 23 two two CD cord-005453-4057qib7 9187 24 groups group NNS cord-005453-4057qib7 9187 25 . . . cord-005453-4057qib7 9188 1 In in IN cord-005453-4057qib7 9188 2 univariate univariate JJ cord-005453-4057qib7 9188 3 analysis analysis NN cord-005453-4057qib7 9188 4 , , , cord-005453-4057qib7 9188 5 FQ FQ NNP cord-005453-4057qib7 9188 6 prophylaxis prophylaxis NN cord-005453-4057qib7 9188 7 ( ( -LRB- cord-005453-4057qib7 9188 8 OR or CC cord-005453-4057qib7 9188 9 0,54 0,54 CD cord-005453-4057qib7 9188 10 ; ; : cord-005453-4057qib7 9188 11 95 95 CD cord-005453-4057qib7 9188 12 % % NN cord-005453-4057qib7 9188 13 IC IC NNP cord-005453-4057qib7 9188 14 0,30 0,30 NNP cord-005453-4057qib7 9188 15 - - HYPH cord-005453-4057qib7 9188 16 0,97 0,97 CD cord-005453-4057qib7 9188 17 ) ) -RRB- cord-005453-4057qib7 9188 18 and and CC cord-005453-4057qib7 9188 19 bone bone NN cord-005453-4057qib7 9188 20 marrow marrow NN cord-005453-4057qib7 9188 21 stem stem NN cord-005453-4057qib7 9188 22 cell cell NN cord-005453-4057qib7 9188 23 source source NN cord-005453-4057qib7 9188 24 ( ( -LRB- cord-005453-4057qib7 9188 25 OR or CC cord-005453-4057qib7 9188 26 2,08 2,08 CD cord-005453-4057qib7 9188 27 ; ; : cord-005453-4057qib7 9188 28 95 95 CD cord-005453-4057qib7 9188 29 % % NN cord-005453-4057qib7 9188 30 IC IC NNP cord-005453-4057qib7 9188 31 1,05 1,05 NNP cord-005453-4057qib7 9188 32 - - HYPH cord-005453-4057qib7 9188 33 4,12 4,12 CD cord-005453-4057qib7 9188 34 ) ) -RRB- cord-005453-4057qib7 9188 35 were be VBD cord-005453-4057qib7 9188 36 significant significant JJ cord-005453-4057qib7 9188 37 factors factor NNS cord-005453-4057qib7 9188 38 associated associate VBN cord-005453-4057qib7 9188 39 with with IN cord-005453-4057qib7 9188 40 the the DT cord-005453-4057qib7 9188 41 risk risk NN cord-005453-4057qib7 9188 42 of of IN cord-005453-4057qib7 9188 43 BSI BSI NNP cord-005453-4057qib7 9188 44 . . . cord-005453-4057qib7 9189 1 Gramnegative gramnegative JJ cord-005453-4057qib7 9189 2 bacteria bacteria NNS cord-005453-4057qib7 9189 3 accounted account VBD cord-005453-4057qib7 9189 4 for for IN cord-005453-4057qib7 9189 5 44,8 44,8 CD cord-005453-4057qib7 9189 6 % % NN cord-005453-4057qib7 9189 7 ( ( -LRB- cord-005453-4057qib7 9189 8 n=13 n=13 NNP cord-005453-4057qib7 9189 9 ) ) -RRB- cord-005453-4057qib7 9189 10 of of IN cord-005453-4057qib7 9189 11 BSI BSI NNP cord-005453-4057qib7 9189 12 in in IN cord-005453-4057qib7 9189 13 group group NN cord-005453-4057qib7 9189 14 A A NNP cord-005453-4057qib7 9189 15 and and CC cord-005453-4057qib7 9189 16 65,5 65,5 CD cord-005453-4057qib7 9189 17 % % NN cord-005453-4057qib7 9190 1 ( ( -LRB- cord-005453-4057qib7 9190 2 n= n= NNP cord-005453-4057qib7 9190 3 19 19 CD cord-005453-4057qib7 9190 4 ) ) -RRB- cord-005453-4057qib7 9190 5 in in IN cord-005453-4057qib7 9190 6 group group NN cord-005453-4057qib7 9190 7 B B NNP cord-005453-4057qib7 9190 8 , , , cord-005453-4057qib7 9190 9 and and CC cord-005453-4057qib7 9190 10 gram gram NN cord-005453-4057qib7 9190 11 - - HYPH cord-005453-4057qib7 9190 12 positive positive JJ cord-005453-4057qib7 9190 13 bacteria bacteria NNS cord-005453-4057qib7 9190 14 for for IN cord-005453-4057qib7 9190 15 48,3 48,3 CD cord-005453-4057qib7 9190 16 % % NN cord-005453-4057qib7 9191 1 ( ( -LRB- cord-005453-4057qib7 9191 2 n= n= NNP cord-005453-4057qib7 9191 3 14 14 CD cord-005453-4057qib7 9191 4 ) ) -RRB- cord-005453-4057qib7 9191 5 of of IN cord-005453-4057qib7 9191 6 BSI BSI NNP cord-005453-4057qib7 9191 7 in in IN cord-005453-4057qib7 9191 8 group group NN cord-005453-4057qib7 9191 9 A A NNP cord-005453-4057qib7 9191 10 versus versus IN cord-005453-4057qib7 9191 11 27,5 27,5 CD cord-005453-4057qib7 9191 12 % % NN cord-005453-4057qib7 9192 1 ( ( -LRB- cord-005453-4057qib7 9192 2 n= n= NNP cord-005453-4057qib7 9192 3 8) 8) NNP cord-005453-4057qib7 9193 1 in in IN cord-005453-4057qib7 9193 2 group group NN cord-005453-4057qib7 9193 3 B B NNP cord-005453-4057qib7 9193 4 , , , cord-005453-4057qib7 9193 5 without without IN cord-005453-4057qib7 9193 6 statistically statistically RB cord-005453-4057qib7 9193 7 significant significant JJ cord-005453-4057qib7 9193 8 differences difference NNS cord-005453-4057qib7 9193 9 ( ( -LRB- cord-005453-4057qib7 9193 10 p p NN cord-005453-4057qib7 9193 11 = = SYM cord-005453-4057qib7 9193 12 0,16 0,16 NNP cord-005453-4057qib7 9193 13 ) ) -RRB- cord-005453-4057qib7 9193 14 . . . cord-005453-4057qib7 9194 1 Polymicrobic Polymicrobic NNP cord-005453-4057qib7 9194 2 BSI BSI NNP cord-005453-4057qib7 9194 3 were be VBD cord-005453-4057qib7 9194 4 6,9 6,9 CD cord-005453-4057qib7 9194 5 % % NN cord-005453-4057qib7 9194 6 ( ( -LRB- cord-005453-4057qib7 9194 7 n=2 n=2 NNS cord-005453-4057qib7 9194 8 ) ) -RRB- cord-005453-4057qib7 9194 9 in in IN cord-005453-4057qib7 9194 10 group group NN cord-005453-4057qib7 9194 11 A A NNP cord-005453-4057qib7 9194 12 and and CC cord-005453-4057qib7 9194 13 6,9 6,9 CD cord-005453-4057qib7 9194 14 % % NN cord-005453-4057qib7 9194 15 ( ( -LRB- cord-005453-4057qib7 9194 16 n=2 n=2 NNS cord-005453-4057qib7 9194 17 ) ) -RRB- cord-005453-4057qib7 9194 18 in in IN cord-005453-4057qib7 9194 19 group group NN cord-005453-4057qib7 9194 20 B. B. NNP cord-005453-4057qib7 9194 21 MDRgram MDRgram NNP cord-005453-4057qib7 9195 1 negative negative JJ cord-005453-4057qib7 9195 2 BSI BSI NNP cord-005453-4057qib7 9195 3 were be VBD cord-005453-4057qib7 9195 4 detected detect VBN cord-005453-4057qib7 9195 5 in in IN cord-005453-4057qib7 9195 6 4 4 CD cord-005453-4057qib7 9195 7 patients patient NNS cord-005453-4057qib7 9195 8 ( ( -LRB- cord-005453-4057qib7 9195 9 14 14 CD cord-005453-4057qib7 9195 10 % % NN cord-005453-4057qib7 9195 11 ) ) -RRB- cord-005453-4057qib7 9195 12 in in IN cord-005453-4057qib7 9195 13 group group NN cord-005453-4057qib7 9195 14 A A NNP cord-005453-4057qib7 9195 15 and and CC cord-005453-4057qib7 9195 16 in in IN cord-005453-4057qib7 9195 17 6 6 CD cord-005453-4057qib7 9195 18 patients patient NNS cord-005453-4057qib7 9195 19 ( ( -LRB- cord-005453-4057qib7 9195 20 20,7 20,7 CD cord-005453-4057qib7 9195 21 % % NN cord-005453-4057qib7 9195 22 ) ) -RRB- cord-005453-4057qib7 9195 23 in in IN cord-005453-4057qib7 9195 24 group group NN cord-005453-4057qib7 9195 25 B b NN cord-005453-4057qib7 9195 26 ( ( -LRB- cord-005453-4057qib7 9195 27 overall overall RB cord-005453-4057qib7 9195 28 , , , cord-005453-4057qib7 9195 29 2 2 CD cord-005453-4057qib7 9195 30 CRE cre NN cord-005453-4057qib7 9195 31 , , , cord-005453-4057qib7 9195 32 7 7 CD cord-005453-4057qib7 9195 33 ESBL ESBL NNP cord-005453-4057qib7 9195 34 producing produce VBG cord-005453-4057qib7 9195 35 enterobacteriaceae enterobacteriaceae NNS cord-005453-4057qib7 9195 36 and and CC cord-005453-4057qib7 9195 37 1 1 CD cord-005453-4057qib7 9195 38 MDR MDR NNP cord-005453-4057qib7 9195 39 - - HYPH cord-005453-4057qib7 9195 40 Pseudomonas Pseudomonas NNP cord-005453-4057qib7 9195 41 ) ) -RRB- cord-005453-4057qib7 9195 42 . . . cord-005453-4057qib7 9196 1 Death death NN cord-005453-4057qib7 9196 2 attributable attributable JJ cord-005453-4057qib7 9196 3 to to IN cord-005453-4057qib7 9196 4 BSI BSI NNP cord-005453-4057qib7 9196 5 occurred occur VBD cord-005453-4057qib7 9196 6 in in IN cord-005453-4057qib7 9196 7 6 6 CD cord-005453-4057qib7 9196 8 of of IN cord-005453-4057qib7 9196 9 58 58 CD cord-005453-4057qib7 9196 10 patients patient NNS cord-005453-4057qib7 9196 11 ( ( -LRB- cord-005453-4057qib7 9196 12 10,3 10,3 CD cord-005453-4057qib7 9196 13 % % NN cord-005453-4057qib7 9196 14 ) ) -RRB- cord-005453-4057qib7 9196 15 ; ; : cord-005453-4057qib7 9196 16 5 5 CD cord-005453-4057qib7 9196 17 of of IN cord-005453-4057qib7 9196 18 these these DT cord-005453-4057qib7 9196 19 patients patient NNS cord-005453-4057qib7 9196 20 did do VBD cord-005453-4057qib7 9196 21 not not RB cord-005453-4057qib7 9196 22 receive receive VB cord-005453-4057qib7 9196 23 FQ FQ NNP cord-005453-4057qib7 9196 24 prophylaxis prophylaxis NN cord-005453-4057qib7 9196 25 , , , cord-005453-4057qib7 9196 26 but but CC cord-005453-4057qib7 9196 27 2 2 CD cord-005453-4057qib7 9196 28 of of IN cord-005453-4057qib7 9196 29 them -PRON- PRP cord-005453-4057qib7 9196 30 had have VBD cord-005453-4057qib7 9196 31 both both CC cord-005453-4057qib7 9196 32 a a DT cord-005453-4057qib7 9196 33 pre pre JJ cord-005453-4057qib7 9196 34 transplant transplant NN cord-005453-4057qib7 9196 35 KPC KPC NNP cord-005453-4057qib7 9196 36 colonization colonization NN cord-005453-4057qib7 9196 37 and and CC cord-005453-4057qib7 9196 38 active active JJ cord-005453-4057qib7 9196 39 disease disease NN cord-005453-4057qib7 9196 40 at at IN cord-005453-4057qib7 9196 41 transplant transplant NN cord-005453-4057qib7 9196 42 . . . cord-005453-4057qib7 9197 1 Neither neither DT cord-005453-4057qib7 9197 2 antibacterial antibacterial JJ cord-005453-4057qib7 9197 3 prophylaxis prophylaxis NN cord-005453-4057qib7 9197 4 ( ( -LRB- cord-005453-4057qib7 9197 5 p p NN cord-005453-4057qib7 9197 6 = = SYM cord-005453-4057qib7 9197 7 0,98 0,98 CD cord-005453-4057qib7 9197 8 ) ) -RRB- cord-005453-4057qib7 9197 9 nor nor CC cord-005453-4057qib7 9197 10 BSI BSI NNP cord-005453-4057qib7 9197 11 ( ( -LRB- cord-005453-4057qib7 9197 12 p p NN cord-005453-4057qib7 9197 13 = = SYM cord-005453-4057qib7 9197 14 0,4 0,4 CD cord-005453-4057qib7 9197 15 ) ) -RRB- cord-005453-4057qib7 9197 16 had have VBD cord-005453-4057qib7 9197 17 a a DT cord-005453-4057qib7 9197 18 significant significant JJ cord-005453-4057qib7 9197 19 impact impact NN cord-005453-4057qib7 9197 20 on on IN cord-005453-4057qib7 9197 21 overall overall JJ cord-005453-4057qib7 9197 22 survival survival NN cord-005453-4057qib7 9197 23 ( ( -LRB- cord-005453-4057qib7 9197 24 OS OS NNP cord-005453-4057qib7 9197 25 ) ) -RRB- cord-005453-4057qib7 9197 26 . . . cord-005453-4057qib7 9198 1 Conclusions conclusion NNS cord-005453-4057qib7 9198 2 : : : cord-005453-4057qib7 9199 1 The the DT cord-005453-4057qib7 9199 2 preliminary preliminary JJ cord-005453-4057qib7 9199 3 data datum NNS cord-005453-4057qib7 9199 4 of of IN cord-005453-4057qib7 9199 5 our -PRON- PRP$ cord-005453-4057qib7 9199 6 study study NN cord-005453-4057qib7 9199 7 show show NN cord-005453-4057qib7 9199 8 that that IN cord-005453-4057qib7 9199 9 FQ FQ NNP cord-005453-4057qib7 9199 10 prophylaxis prophylaxis NN cord-005453-4057qib7 9199 11 is be VBZ cord-005453-4057qib7 9199 12 associated associate VBN cord-005453-4057qib7 9199 13 with with IN cord-005453-4057qib7 9199 14 a a DT cord-005453-4057qib7 9199 15 reduced reduce VBN cord-005453-4057qib7 9199 16 incidence incidence NN cord-005453-4057qib7 9199 17 of of IN cord-005453-4057qib7 9199 18 BSI BSI NNP cord-005453-4057qib7 9199 19 , , , cord-005453-4057qib7 9199 20 in in IN cord-005453-4057qib7 9199 21 particular particular JJ cord-005453-4057qib7 9199 22 Gram gram NN cord-005453-4057qib7 9199 23 - - HYPH cord-005453-4057qib7 9199 24 negative negative JJ cord-005453-4057qib7 9199 25 infections infection NNS cord-005453-4057qib7 9199 26 , , , cord-005453-4057qib7 9199 27 with with IN cord-005453-4057qib7 9199 28 no no DT cord-005453-4057qib7 9199 29 impact impact NN cord-005453-4057qib7 9199 30 on on IN cord-005453-4057qib7 9199 31 OS OS NNP cord-005453-4057qib7 9199 32 . . . cord-005453-4057qib7 9200 1 The the DT cord-005453-4057qib7 9200 2 limitations limitation NNS cord-005453-4057qib7 9200 3 of of IN cord-005453-4057qib7 9200 4 our -PRON- PRP$ cord-005453-4057qib7 9200 5 study study NN cord-005453-4057qib7 9200 6 may may MD cord-005453-4057qib7 9200 7 be be VB cord-005453-4057qib7 9200 8 the the DT cord-005453-4057qib7 9200 9 different different JJ cord-005453-4057qib7 9200 10 group group NN cord-005453-4057qib7 9200 11 sizes size NNS cord-005453-4057qib7 9200 12 and and CC cord-005453-4057qib7 9200 13 the the DT cord-005453-4057qib7 9200 14 retrospective retrospective JJ cord-005453-4057qib7 9200 15 nauture nauture NN cord-005453-4057qib7 9200 16 of of IN cord-005453-4057qib7 9200 17 the the DT cord-005453-4057qib7 9200 18 study study NN cord-005453-4057qib7 9200 19 . . . cord-005453-4057qib7 9201 1 Whether whether IN cord-005453-4057qib7 9201 2 antibacterial antibacterial JJ cord-005453-4057qib7 9201 3 prophylaxis prophylaxis NN cord-005453-4057qib7 9201 4 should should MD cord-005453-4057qib7 9201 5 be be VB cord-005453-4057qib7 9201 6 avoided avoid VBN cord-005453-4057qib7 9201 7 in in IN cord-005453-4057qib7 9201 8 the the DT cord-005453-4057qib7 9201 9 pre pre JJ cord-005453-4057qib7 9201 10 - - JJ cord-005453-4057qib7 9201 11 engraftment engraftment JJ cord-005453-4057qib7 9201 12 period period NN cord-005453-4057qib7 9201 13 in in IN cord-005453-4057qib7 9201 14 still still RB cord-005453-4057qib7 9201 15 a a DT cord-005453-4057qib7 9201 16 matter matter NN cord-005453-4057qib7 9201 17 of of IN cord-005453-4057qib7 9201 18 debate debate NN cord-005453-4057qib7 9201 19 and and CC cord-005453-4057qib7 9201 20 needs need VBZ cord-005453-4057qib7 9201 21 to to TO cord-005453-4057qib7 9201 22 be be VB cord-005453-4057qib7 9201 23 evaluated evaluate VBN cord-005453-4057qib7 9201 24 in in IN cord-005453-4057qib7 9201 25 larger large JJR cord-005453-4057qib7 9201 26 prospective prospective JJ cord-005453-4057qib7 9201 27 studies study NNS cord-005453-4057qib7 9201 28 . . . cord-005453-4057qib7 9202 1 Disclosure disclosure NN cord-005453-4057qib7 9202 2 : : : cord-005453-4057qib7 9202 3 Nothing nothing NN cord-005453-4057qib7 9202 4 to to TO cord-005453-4057qib7 9202 5 disclose disclose VB cord-005453-4057qib7 9202 6 . . . cord-005453-4057qib7 9203 1 Gillen Gillen NNP cord-005453-4057qib7 9203 2 Oarbeascoa Oarbeascoa NNP cord-005453-4057qib7 9203 3 1 1 CD cord-005453-4057qib7 9203 4 , , , cord-005453-4057qib7 9203 5 Nieves Nieves NNP cord-005453-4057qib7 9203 6 Dorado Dorado NNP cord-005453-4057qib7 9203 7 1,2 1,2 CD cord-005453-4057qib7 9203 8 , , , cord-005453-4057qib7 9203 9 Laura Laura NNP cord-005453-4057qib7 9203 10 Solan Solan NNP cord-005453-4057qib7 9203 11 1,2 1,2 CD cord-005453-4057qib7 9203 12 , , , cord-005453-4057qib7 9203 13 Rebeca Rebeca NNP cord-005453-4057qib7 9203 14 Bailen Bailen NNP cord-005453-4057qib7 9203 15 1,2 1,2 CD cord-005453-4057qib7 9203 16 , , , cord-005453-4057qib7 9203 17 Pascual Pascual NNP cord-005453-4057qib7 9203 18 Balsalobre Balsalobre NNP cord-005453-4057qib7 9203 19 1,2 1,2 CD cord-005453-4057qib7 9203 20 , , , cord-005453-4057qib7 9203 21 Carolina Carolina NNP cord-005453-4057qib7 9203 22 Martinez Martinez NNP cord-005453-4057qib7 9203 23 - - HYPH cord-005453-4057qib7 9203 24 Laperche Laperche NNP cord-005453-4057qib7 9203 25 1,2 1,2 CD cord-005453-4057qib7 9203 26 , , , cord-005453-4057qib7 9203 27 Ismael Ismael NNP cord-005453-4057qib7 9203 28 Buño Buño NNP cord-005453-4057qib7 9203 29 1,2 1,2 CD cord-005453-4057qib7 9203 30 , , , cord-005453-4057qib7 9203 31 Javier Javier NNP cord-005453-4057qib7 9203 32 Anguita Anguita NNP cord-005453-4057qib7 9203 33 1,2 1,2 CD cord-005453-4057qib7 9203 34 , , , cord-005453-4057qib7 9203 35 Jose Jose NNP cord-005453-4057qib7 9203 36 Luis Luis NNP cord-005453-4057qib7 9203 37 Diez Diez NNP cord-005453-4057qib7 9203 38 - - HYPH cord-005453-4057qib7 9203 39 Martin Martin NNP cord-005453-4057qib7 9203 40 1,2,3 1,2,3 CD cord-005453-4057qib7 9203 41 , , , cord-005453-4057qib7 9203 42 Mi Mi NNP cord-005453-4057qib7 9203 43 Kwon Kwon NNP cord-005453-4057qib7 9203 44 1,2 1,2 CD cord-005453-4057qib7 9203 45 1 1 CD cord-005453-4057qib7 9203 46 Hospital Hospital NNP cord-005453-4057qib7 9203 47 General General NNP cord-005453-4057qib7 9203 48 Universitario Universitario NNP cord-005453-4057qib7 9203 49 Gregorio Gregorio NNP cord-005453-4057qib7 9203 50 Marañón Marañón NNP cord-005453-4057qib7 9203 51 , , , cord-005453-4057qib7 9203 52 Hematology Hematology NNP cord-005453-4057qib7 9203 53 , , , cord-005453-4057qib7 9203 54 Madrid Madrid NNP cord-005453-4057qib7 9203 55 , , , cord-005453-4057qib7 9203 56 Spain Spain NNP cord-005453-4057qib7 9203 57 , , , cord-005453-4057qib7 9203 58 2 2 CD cord-005453-4057qib7 9203 59 Instituto Instituto NNP cord-005453-4057qib7 9203 60 de de NNP cord-005453-4057qib7 9203 61 Investigación Investigación NNP cord-005453-4057qib7 9203 62 Sanitaria Sanitaria NNP cord-005453-4057qib7 9203 63 Gregorio Gregorio NNP cord-005453-4057qib7 9203 64 Marañón Marañón NNP cord-005453-4057qib7 9203 65 , , , cord-005453-4057qib7 9203 66 Madrid Madrid NNP cord-005453-4057qib7 9203 67 , , , cord-005453-4057qib7 9203 68 Spain Spain NNP cord-005453-4057qib7 9203 69 , , , cord-005453-4057qib7 9203 70 3 3 CD cord-005453-4057qib7 9203 71 Universidad Universidad NNP cord-005453-4057qib7 9203 72 Complutense Complutense NNP cord-005453-4057qib7 9203 73 de de NNP cord-005453-4057qib7 9203 74 Madrid Madrid NNP cord-005453-4057qib7 9203 75 , , , cord-005453-4057qib7 9203 76 Madrid Madrid NNP cord-005453-4057qib7 9203 77 , , , cord-005453-4057qib7 9204 1 Spain Spain NNP cord-005453-4057qib7 9204 2 Background Background NNP cord-005453-4057qib7 9204 3 : : : cord-005453-4057qib7 9205 1 Incidence incidence NN cord-005453-4057qib7 9205 2 and and CC cord-005453-4057qib7 9205 3 outcome outcome NN cord-005453-4057qib7 9205 4 of of IN cord-005453-4057qib7 9205 5 Invasive invasive JJ cord-005453-4057qib7 9205 6 Fungal Fungal NNP cord-005453-4057qib7 9205 7 Infection infection NN cord-005453-4057qib7 9205 8 ( ( -LRB- cord-005453-4057qib7 9205 9 IFI IFI NNP cord-005453-4057qib7 9205 10 ) ) -RRB- cord-005453-4057qib7 9205 11 are be VBP cord-005453-4057qib7 9205 12 not not RB cord-005453-4057qib7 9205 13 well well RB cord-005453-4057qib7 9205 14 characterized characterize VBN cord-005453-4057qib7 9205 15 in in IN cord-005453-4057qib7 9205 16 the the DT cord-005453-4057qib7 9205 17 setting setting NN cord-005453-4057qib7 9205 18 of of IN cord-005453-4057qib7 9205 19 peripheral peripheral JJ cord-005453-4057qib7 9205 20 blood blood NN cord-005453-4057qib7 9205 21 , , , cord-005453-4057qib7 9205 22 non non JJ cord-005453-4057qib7 9205 23 - - JJ cord-005453-4057qib7 9205 24 manipulated manipulate VBN cord-005453-4057qib7 9205 25 haploidentical haploidentical JJ cord-005453-4057qib7 9205 26 stem stem NN cord-005453-4057qib7 9205 27 cell cell NN cord-005453-4057qib7 9205 28 transplantation transplantation NN cord-005453-4057qib7 9205 29 with with IN cord-005453-4057qib7 9205 30 postransplant postransplant NN cord-005453-4057qib7 9205 31 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 9205 32 ( ( -LRB- cord-005453-4057qib7 9205 33 HaploSCT HaploSCT NNP cord-005453-4057qib7 9205 34 ) ) -RRB- cord-005453-4057qib7 9205 35 . . . cord-005453-4057qib7 9206 1 The the DT cord-005453-4057qib7 9206 2 aim aim NN cord-005453-4057qib7 9206 3 of of IN cord-005453-4057qib7 9206 4 the the DT cord-005453-4057qib7 9206 5 study study NN cord-005453-4057qib7 9206 6 was be VBD cord-005453-4057qib7 9206 7 to to TO cord-005453-4057qib7 9206 8 analyze analyze VB cord-005453-4057qib7 9206 9 incidence incidence NN cord-005453-4057qib7 9206 10 and and CC cord-005453-4057qib7 9206 11 risk risk NN cord-005453-4057qib7 9206 12 factors factor NNS cord-005453-4057qib7 9206 13 of of IN cord-005453-4057qib7 9206 14 IFI IFI NNP cord-005453-4057qib7 9206 15 in in IN cord-005453-4057qib7 9206 16 patients patient NNS cord-005453-4057qib7 9206 17 who who WP cord-005453-4057qib7 9206 18 underwent undergo VBD cord-005453-4057qib7 9206 19 HaploSCT HaploSCT NNP cord-005453-4057qib7 9206 20 at at IN cord-005453-4057qib7 9206 21 our -PRON- PRP$ cord-005453-4057qib7 9206 22 institution institution NN cord-005453-4057qib7 9206 23 . . . cord-005453-4057qib7 9207 1 Methods method NNS cord-005453-4057qib7 9207 2 : : : cord-005453-4057qib7 9207 3 132 132 CD cord-005453-4057qib7 9207 4 consecutive consecutive JJ cord-005453-4057qib7 9207 5 patients patient NNS cord-005453-4057qib7 9207 6 who who WP cord-005453-4057qib7 9207 7 underwent undergo VBD cord-005453-4057qib7 9207 8 peripheral peripheral JJ cord-005453-4057qib7 9207 9 blood blood NN cord-005453-4057qib7 9207 10 HaploSCT HaploSCT NNP cord-005453-4057qib7 9207 11 with with IN cord-005453-4057qib7 9207 12 postransplant postransplant NN cord-005453-4057qib7 9207 13 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 9207 14 between between IN cord-005453-4057qib7 9207 15 2011 2011 CD cord-005453-4057qib7 9207 16 and and CC cord-005453-4057qib7 9207 17 2017 2017 CD cord-005453-4057qib7 9207 18 at at IN cord-005453-4057qib7 9207 19 our -PRON- PRP$ cord-005453-4057qib7 9207 20 centre centre NN cord-005453-4057qib7 9207 21 were be VBD cord-005453-4057qib7 9207 22 reviewed review VBN cord-005453-4057qib7 9207 23 . . . cord-005453-4057qib7 9208 1 IFI IFI NNP cord-005453-4057qib7 9208 2 was be VBD cord-005453-4057qib7 9208 3 classified classify VBN cord-005453-4057qib7 9208 4 according accord VBG cord-005453-4057qib7 9208 5 to to IN cord-005453-4057qib7 9208 6 EORTC EORTC NNP cord-005453-4057qib7 9208 7 definitions definition NNS cord-005453-4057qib7 9208 8 . . . cord-005453-4057qib7 9209 1 Proven proven JJ cord-005453-4057qib7 9209 2 and and CC cord-005453-4057qib7 9209 3 probable probable JJ cord-005453-4057qib7 9209 4 IFI IFI NNP cord-005453-4057qib7 9209 5 were be VBD cord-005453-4057qib7 9209 6 included include VBN cord-005453-4057qib7 9209 7 . . . cord-005453-4057qib7 9210 1 Results result NNS cord-005453-4057qib7 9210 2 : : : cord-005453-4057qib7 9211 1 Patients´characteristics patients´characteristic NNS cord-005453-4057qib7 9211 2 are be VBP cord-005453-4057qib7 9211 3 shown show VBN cord-005453-4057qib7 9211 4 in in IN cord-005453-4057qib7 9211 5 Table Table NNP cord-005453-4057qib7 9211 6 1 1 CD cord-005453-4057qib7 9211 7 . . . cord-005453-4057qib7 9212 1 Primary primary JJ cord-005453-4057qib7 9212 2 antifungal antifungal JJ cord-005453-4057qib7 9212 3 prophylaxis prophylaxis NN cord-005453-4057qib7 9212 4 was be VBD cord-005453-4057qib7 9212 5 performed perform VBN cord-005453-4057qib7 9212 6 with with IN cord-005453-4057qib7 9212 7 micafungin micafungin NNP cord-005453-4057qib7 9212 8 from from IN cord-005453-4057qib7 9212 9 day day NN cord-005453-4057qib7 9212 10 -1 -1 CD cord-005453-4057qib7 9212 11 until until IN cord-005453-4057qib7 9212 12 oral oral JJ cord-005453-4057qib7 9212 13 intake intake NN cord-005453-4057qib7 9212 14 , , , cord-005453-4057qib7 9212 15 followed follow VBN cord-005453-4057qib7 9212 16 by by IN cord-005453-4057qib7 9212 17 posaconazole posaconazole NNP cord-005453-4057qib7 9212 18 until until IN cord-005453-4057qib7 9212 19 day day NN cord-005453-4057qib7 9212 20 +35 +35 CD cord-005453-4057qib7 9212 21 . . . cord-005453-4057qib7 9213 1 Patients patient NNS cord-005453-4057qib7 9213 2 on on IN cord-005453-4057qib7 9213 3 steroid steroid NN cord-005453-4057qib7 9213 4 treatment treatment NN cord-005453-4057qib7 9213 5 for for IN cord-005453-4057qib7 9213 6 GVHD GVHD NNP cord-005453-4057qib7 9213 7 received receive VBD cord-005453-4057qib7 9213 8 prophylaxis prophylaxis NN cord-005453-4057qib7 9213 9 with with IN cord-005453-4057qib7 9213 10 micafungin micafungin NNP cord-005453-4057qib7 9213 11 or or CC cord-005453-4057qib7 9213 12 posaconazole posaconazole NNP cord-005453-4057qib7 9213 13 . . . cord-005453-4057qib7 9214 1 92 92 CD cord-005453-4057qib7 9214 2 % % NN cord-005453-4057qib7 9214 3 of of IN cord-005453-4057qib7 9214 4 patients patient NNS cord-005453-4057qib7 9214 5 obtained obtain VBN cord-005453-4057qib7 9214 6 neutrophil neutrophil NN cord-005453-4057qib7 9214 7 engraftment engraftment NN cord-005453-4057qib7 9214 8 . . . cord-005453-4057qib7 9215 1 Twenty twenty CD cord-005453-4057qib7 9215 2 - - HYPH cord-005453-4057qib7 9215 3 two two CD cord-005453-4057qib7 9215 4 episodes episode NNS cord-005453-4057qib7 9215 5 of of IN cord-005453-4057qib7 9215 6 IFI IFI NNP cord-005453-4057qib7 9215 7 were be VBD cord-005453-4057qib7 9215 8 observed observe VBN cord-005453-4057qib7 9215 9 in in IN cord-005453-4057qib7 9215 10 20 20 CD cord-005453-4057qib7 9215 11 patients patient NNS cord-005453-4057qib7 9215 12 : : : cord-005453-4057qib7 9215 13 10 10 CD cord-005453-4057qib7 9215 14 proven prove VBN cord-005453-4057qib7 9215 15 and and CC cord-005453-4057qib7 9215 16 12 12 CD cord-005453-4057qib7 9215 17 probable probable JJ cord-005453-4057qib7 9215 18 , , , cord-005453-4057qib7 9215 19 with with IN cord-005453-4057qib7 9215 20 a a DT cord-005453-4057qib7 9215 21 cumulative cumulative JJ cord-005453-4057qib7 9215 22 incidence incidence NN cord-005453-4057qib7 9215 23 of of IN cord-005453-4057qib7 9215 24 IFI IFI NNP cord-005453-4057qib7 9215 25 of of IN cord-005453-4057qib7 9215 26 17 17 CD cord-005453-4057qib7 9215 27 % % NN cord-005453-4057qib7 9215 28 at at IN cord-005453-4057qib7 9215 29 500 500 CD cord-005453-4057qib7 9215 30 days day NNS cord-005453-4057qib7 9215 31 . . . cord-005453-4057qib7 9216 1 Most most RBS cord-005453-4057qib7 9216 2 commonly commonly RB cord-005453-4057qib7 9216 3 isolated isolate VBN cord-005453-4057qib7 9216 4 organism organism NN cord-005453-4057qib7 9216 5 was be VBD cord-005453-4057qib7 9216 6 Aspergillus aspergillus NN cord-005453-4057qib7 9216 7 spp spp NNS cord-005453-4057qib7 9216 8 ( ( -LRB- cord-005453-4057qib7 9216 9 n=5 n=5 NNP cord-005453-4057qib7 9216 10 ) ) -RRB- cord-005453-4057qib7 9216 11 , , , cord-005453-4057qib7 9216 12 followed follow VBN cord-005453-4057qib7 9216 13 by by IN cord-005453-4057qib7 9216 14 Candida Candida NNP cord-005453-4057qib7 9216 15 spp spp NNS cord-005453-4057qib7 9216 16 ( ( -LRB- cord-005453-4057qib7 9216 17 n=4 n=4 NNS cord-005453-4057qib7 9216 18 : : : cord-005453-4057qib7 9216 19 1 1 CD cord-005453-4057qib7 9216 20 C. C. NNP cord-005453-4057qib7 9216 21 kruseii kruseii NNP cord-005453-4057qib7 9216 22 and and CC cord-005453-4057qib7 9216 23 3 3 CD cord-005453-4057qib7 9216 24 C. C. NNP cord-005453-4057qib7 9216 25 parapsilosis parapsilosis NNP cord-005453-4057qib7 9216 26 ) ) -RRB- cord-005453-4057qib7 9216 27 , , , cord-005453-4057qib7 9216 28 and and CC cord-005453-4057qib7 9216 29 Fusarium Fusarium NNP cord-005453-4057qib7 9216 30 spp spp NNS cord-005453-4057qib7 9216 31 ( ( -LRB- cord-005453-4057qib7 9216 32 n=2 n=2 NNS cord-005453-4057qib7 9216 33 ) ) -RRB- cord-005453-4057qib7 9216 34 . . . cord-005453-4057qib7 9217 1 Isolated isolated JJ cord-005453-4057qib7 9217 2 cases case NNS cord-005453-4057qib7 9217 3 of of IN cord-005453-4057qib7 9217 4 Inonotus Inonotus NNP cord-005453-4057qib7 9217 5 spp spp NNS cord-005453-4057qib7 9217 6 , , , cord-005453-4057qib7 9217 7 Mucor Mucor NNP cord-005453-4057qib7 9217 8 spp spp NNS cord-005453-4057qib7 9217 9 and and CC cord-005453-4057qib7 9217 10 Trichosporon Trichosporon NNP cord-005453-4057qib7 9217 11 Ashii Ashii NNP cord-005453-4057qib7 9217 12 were be VBD cord-005453-4057qib7 9217 13 observed observe VBN cord-005453-4057qib7 9217 14 . . . cord-005453-4057qib7 9218 1 Pulmonary pulmonary JJ cord-005453-4057qib7 9218 2 involvement involvement NN cord-005453-4057qib7 9218 3 was be VBD cord-005453-4057qib7 9218 4 the the DT cord-005453-4057qib7 9218 5 most most RBS cord-005453-4057qib7 9218 6 frequent frequent JJ cord-005453-4057qib7 9218 7 clinical clinical JJ cord-005453-4057qib7 9218 8 presentation presentation NN cord-005453-4057qib7 9218 9 ( ( -LRB- cord-005453-4057qib7 9218 10 n=10 n=10 NNP cord-005453-4057qib7 9218 11 ) ) -RRB- cord-005453-4057qib7 9218 12 , , , cord-005453-4057qib7 9218 13 followed follow VBN cord-005453-4057qib7 9218 14 by by IN cord-005453-4057qib7 9218 15 fungemia fungemia NNP cord-005453-4057qib7 9218 16 ( ( -LRB- cord-005453-4057qib7 9218 17 n=5 n=5 NNP cord-005453-4057qib7 9218 18 : : : cord-005453-4057qib7 9218 19 4 4 CD cord-005453-4057qib7 9218 20 Candidemia Candidemia NNP cord-005453-4057qib7 9218 21 , , , cord-005453-4057qib7 9218 22 1 1 CD cord-005453-4057qib7 9218 23 Trichosporon Trichosporon NNP cord-005453-4057qib7 9218 24 Ashii Ashii NNP cord-005453-4057qib7 9218 25 ) ) -RRB- cord-005453-4057qib7 9218 26 and and CC cord-005453-4057qib7 9218 27 skin skin NN cord-005453-4057qib7 9218 28 - - HYPH cord-005453-4057qib7 9218 29 pulmonary pulmonary JJ cord-005453-4057qib7 9218 30 involvement involvement NN cord-005453-4057qib7 9218 31 ( ( -LRB- cord-005453-4057qib7 9218 32 n=2 n=2 NNS cord-005453-4057qib7 9218 33 ) ) -RRB- cord-005453-4057qib7 9218 34 . . . cord-005453-4057qib7 9219 1 Among among IN cord-005453-4057qib7 9219 2 patients patient NNS cord-005453-4057qib7 9219 3 with with IN cord-005453-4057qib7 9219 4 lung lung NN cord-005453-4057qib7 9219 5 involvement involvement NN cord-005453-4057qib7 9219 6 , , , cord-005453-4057qib7 9219 7 10 10 CD cord-005453-4057qib7 9219 8 showed show VBD cord-005453-4057qib7 9219 9 probable probable JJ cord-005453-4057qib7 9219 10 IFI IFI NNP cord-005453-4057qib7 9219 11 : : : cord-005453-4057qib7 9219 12 5 5 CD cord-005453-4057qib7 9219 13 with with IN cord-005453-4057qib7 9219 14 elevated elevated JJ cord-005453-4057qib7 9219 15 serum serum NN cord-005453-4057qib7 9219 16 galactomannan galactomannan NN cord-005453-4057qib7 9219 17 and and CC cord-005453-4057qib7 9219 18 3 3 CD cord-005453-4057qib7 9219 19 positive positive JJ cord-005453-4057qib7 9219 20 galactomannan galactomannan NNP cord-005453-4057qib7 9219 21 in in IN cord-005453-4057qib7 9219 22 bronchoalveolar bronchoalveolar NNP cord-005453-4057qib7 9219 23 lavage lavage NNP cord-005453-4057qib7 9219 24 ( ( -LRB- cord-005453-4057qib7 9219 25 BAL BAL NNP cord-005453-4057qib7 9219 26 ) ) -RRB- cord-005453-4057qib7 9219 27 . . . cord-005453-4057qib7 9220 1 There there EX cord-005453-4057qib7 9220 2 were be VBD cord-005453-4057qib7 9220 3 2 2 CD cord-005453-4057qib7 9220 4 patients patient NNS cord-005453-4057qib7 9220 5 without without IN cord-005453-4057qib7 9220 6 galactomannan galactomannan NNP cord-005453-4057qib7 9220 7 , , , cord-005453-4057qib7 9220 8 one one CD cord-005453-4057qib7 9220 9 with with IN cord-005453-4057qib7 9220 10 a a DT cord-005453-4057qib7 9220 11 positive positive JJ cord-005453-4057qib7 9220 12 BAL bal NN cord-005453-4057qib7 9220 13 culture culture NN cord-005453-4057qib7 9220 14 for for IN cord-005453-4057qib7 9220 15 Penicillum Penicillum NNP cord-005453-4057qib7 9220 16 spp spp NNS cord-005453-4057qib7 9220 17 and and CC cord-005453-4057qib7 9220 18 the the DT cord-005453-4057qib7 9220 19 other other JJ cord-005453-4057qib7 9220 20 with with IN cord-005453-4057qib7 9220 21 an an DT cord-005453-4057qib7 9220 22 Aspergillus aspergillus NN cord-005453-4057qib7 9220 23 spp spp NN cord-005453-4057qib7 9220 24 . . . cord-005453-4057qib7 9221 1 Median median JJ cord-005453-4057qib7 9221 2 time time NN cord-005453-4057qib7 9221 3 to to IN cord-005453-4057qib7 9221 4 IFI IFI NNP cord-005453-4057qib7 9221 5 diagnosis diagnosis NN cord-005453-4057qib7 9221 6 was be VBD cord-005453-4057qib7 9221 7 21 21 CD cord-005453-4057qib7 9221 8 days day NNS cord-005453-4057qib7 9221 9 . . . cord-005453-4057qib7 9222 1 Thirteen thirteen CD cord-005453-4057qib7 9222 2 cases case NNS cord-005453-4057qib7 9222 3 were be VBD cord-005453-4057qib7 9222 4 diagnosed diagnose VBN cord-005453-4057qib7 9222 5 in in IN cord-005453-4057qib7 9222 6 the the DT cord-005453-4057qib7 9222 7 pre pre JJ cord-005453-4057qib7 9222 8 - - JJ cord-005453-4057qib7 9222 9 engraftment engraftment JJ cord-005453-4057qib7 9222 10 period period NN cord-005453-4057qib7 9222 11 , , , cord-005453-4057qib7 9222 12 4 4 CD cord-005453-4057qib7 9222 13 after after IN cord-005453-4057qib7 9222 14 engraftment engraftment NN cord-005453-4057qib7 9222 15 and and CC cord-005453-4057qib7 9222 16 5 5 CD cord-005453-4057qib7 9222 17 cases case NNS cord-005453-4057qib7 9222 18 after after IN cord-005453-4057qib7 9222 19 day day NN cord-005453-4057qib7 9222 20 +30 +30 CD cord-005453-4057qib7 9222 21 . . . cord-005453-4057qib7 9223 1 Among among IN cord-005453-4057qib7 9223 2 patients patient NNS cord-005453-4057qib7 9223 3 with with IN cord-005453-4057qib7 9223 4 late late JJ cord-005453-4057qib7 9223 5 IFI IFI NNP cord-005453-4057qib7 9223 6 , , , cord-005453-4057qib7 9223 7 median median JJ cord-005453-4057qib7 9223 8 time time NN cord-005453-4057qib7 9223 9 to to IN cord-005453-4057qib7 9223 10 development development NN cord-005453-4057qib7 9223 11 was be VBD cord-005453-4057qib7 9223 12 220 220 CD cord-005453-4057qib7 9223 13 days day NNS cord-005453-4057qib7 9223 14 . . . cord-005453-4057qib7 9224 1 All all DT cord-005453-4057qib7 9224 2 of of IN cord-005453-4057qib7 9224 3 them -PRON- PRP cord-005453-4057qib7 9224 4 were be VBD cord-005453-4057qib7 9224 5 associated associate VBN cord-005453-4057qib7 9224 6 with with IN cord-005453-4057qib7 9224 7 GVHD GVHD NNP cord-005453-4057qib7 9224 8 ( ( -LRB- cord-005453-4057qib7 9224 9 3 3 CD cord-005453-4057qib7 9224 10 grade grade NN cord-005453-4057qib7 9224 11 III III NNP cord-005453-4057qib7 9224 12 - - HYPH cord-005453-4057qib7 9224 13 IV IV NNP cord-005453-4057qib7 9224 14 acute acute JJ cord-005453-4057qib7 9224 15 GVHD GVHD NNP cord-005453-4057qib7 9224 16 and and CC cord-005453-4057qib7 9224 17 2 2 CD cord-005453-4057qib7 9224 18 moderate moderate JJ cord-005453-4057qib7 9224 19 / / SYM cord-005453-4057qib7 9224 20 severe severe JJ cord-005453-4057qib7 9224 21 chronic chronic JJ cord-005453-4057qib7 9224 22 GVHD GVHD NNP cord-005453-4057qib7 9224 23 ) ) -RRB- cord-005453-4057qib7 9224 24 . . . cord-005453-4057qib7 9225 1 IFI IFI NNP cord-005453-4057qib7 9225 2 outcome outcome NN cord-005453-4057qib7 9225 3 was be VBD cord-005453-4057qib7 9225 4 favorable favorable JJ cord-005453-4057qib7 9225 5 in in IN cord-005453-4057qib7 9225 6 13 13 CD cord-005453-4057qib7 9225 7 out out IN cord-005453-4057qib7 9225 8 of of IN cord-005453-4057qib7 9225 9 the the DT cord-005453-4057qib7 9225 10 22 22 CD cord-005453-4057qib7 9225 11 IFI IFI NNP cord-005453-4057qib7 9225 12 . . . cord-005453-4057qib7 9226 1 Treatment treatment NN cord-005453-4057qib7 9226 2 was be VBD cord-005453-4057qib7 9226 3 liposomal liposomal JJ cord-005453-4057qib7 9226 4 amphotericin amphotericin NNS cord-005453-4057qib7 9226 5 B B NNP cord-005453-4057qib7 9226 6 in in IN cord-005453-4057qib7 9226 7 7 7 CD cord-005453-4057qib7 9226 8 cases case NNS cord-005453-4057qib7 9226 9 , , , cord-005453-4057qib7 9226 10 voriconazole voriconazole NN cord-005453-4057qib7 9226 11 in in IN cord-005453-4057qib7 9226 12 4 4 CD cord-005453-4057qib7 9226 13 and and CC cord-005453-4057qib7 9226 14 combined combine VBN cord-005453-4057qib7 9226 15 treatment treatment NN cord-005453-4057qib7 9226 16 ( ( -LRB- cord-005453-4057qib7 9226 17 amphotericin amphotericin NNS cord-005453-4057qib7 9226 18 B B NNP cord-005453-4057qib7 9226 19 and and CC cord-005453-4057qib7 9226 20 azole azole NNP cord-005453-4057qib7 9226 21 ) ) -RRB- cord-005453-4057qib7 9226 22 in in IN cord-005453-4057qib7 9226 23 6 6 CD cord-005453-4057qib7 9226 24 . . . cord-005453-4057qib7 9227 1 There there EX cord-005453-4057qib7 9227 2 were be VBD cord-005453-4057qib7 9227 3 7 7 CD cord-005453-4057qib7 9227 4 IFI IFI NNP cord-005453-4057qib7 9227 5 related relate VBN cord-005453-4057qib7 9227 6 deaths death NNS cord-005453-4057qib7 9227 7 , , , cord-005453-4057qib7 9227 8 with with IN cord-005453-4057qib7 9227 9 a a DT cord-005453-4057qib7 9227 10 cumulative cumulative JJ cord-005453-4057qib7 9227 11 incidence incidence NN cord-005453-4057qib7 9227 12 of of IN cord-005453-4057qib7 9227 13 IFI IFI NNP cord-005453-4057qib7 9227 14 related relate VBN cord-005453-4057qib7 9227 15 death death NN cord-005453-4057qib7 9227 16 of of IN cord-005453-4057qib7 9227 17 6.4 6.4 CD cord-005453-4057qib7 9227 18 % % NN cord-005453-4057qib7 9227 19 . . . cord-005453-4057qib7 9228 1 Prior prior JJ cord-005453-4057qib7 9228 2 transplant transplant NN cord-005453-4057qib7 9228 3 ( ( -LRB- cord-005453-4057qib7 9228 4 OR or CC cord-005453-4057qib7 9228 5 4.5 4.5 CD cord-005453-4057qib7 9228 6 , , , cord-005453-4057qib7 9228 7 p p NN cord-005453-4057qib7 9228 8 < < XX cord-005453-4057qib7 9228 9 0.01 0.01 CD cord-005453-4057qib7 9228 10 ) ) -RRB- cord-005453-4057qib7 9228 11 , , , cord-005453-4057qib7 9228 12 particularly particularly RB cord-005453-4057qib7 9228 13 alloHSCT alloHSCT NNP cord-005453-4057qib7 9228 14 was be VBD cord-005453-4057qib7 9228 15 associated associate VBN cord-005453-4057qib7 9228 16 to to IN cord-005453-4057qib7 9228 17 IFI IFI NNP cord-005453-4057qib7 9228 18 development development NN cord-005453-4057qib7 9228 19 ( ( -LRB- cord-005453-4057qib7 9228 20 OR OR NNP cord-005453-4057qib7 9228 21 8.2 8.2 CD cord-005453-4057qib7 9228 22 , , , cord-005453-4057qib7 9228 23 p p NN cord-005453-4057qib7 9228 24 < < XX cord-005453-4057qib7 9228 25 0.01 0.01 CD cord-005453-4057qib7 9228 26 ) ) -RRB- cord-005453-4057qib7 9228 27 . . . cord-005453-4057qib7 9229 1 Patients patient NNS cord-005453-4057qib7 9229 2 with with IN cord-005453-4057qib7 9229 3 previous previous JJ cord-005453-4057qib7 9229 4 alloHSCT alloHSCT NNP cord-005453-4057qib7 9229 5 presented present VBN cord-005453-4057qib7 9229 6 IFI IFI NNP cord-005453-4057qib7 9229 7 mainly mainly RB cord-005453-4057qib7 9229 8 from from IN cord-005453-4057qib7 9229 9 molds mold NNS cord-005453-4057qib7 9229 10 : : : cord-005453-4057qib7 9230 1 3 3 CD cord-005453-4057qib7 9230 2 Aspergillus aspergillus NN cord-005453-4057qib7 9230 3 , , , cord-005453-4057qib7 9230 4 2 2 CD cord-005453-4057qib7 9230 5 Fusarium fusarium NN cord-005453-4057qib7 9230 6 , , , cord-005453-4057qib7 9230 7 Inonotus Inonotus NNP cord-005453-4057qib7 9230 8 , , , cord-005453-4057qib7 9230 9 Trichosporon Trichosporon NNP cord-005453-4057qib7 9230 10 and and CC cord-005453-4057qib7 9230 11 Mucor Mucor NNP cord-005453-4057qib7 9230 12 . . . cord-005453-4057qib7 9231 1 There there EX cord-005453-4057qib7 9231 2 were be VBD cord-005453-4057qib7 9231 3 also also RB cord-005453-4057qib7 9231 4 2 2 CD cord-005453-4057qib7 9231 5 candidemia candidemia NN cord-005453-4057qib7 9231 6 episodes episode NNS cord-005453-4057qib7 9231 7 . . . cord-005453-4057qib7 9232 1 No no DT cord-005453-4057qib7 9232 2 other other JJ cord-005453-4057qib7 9232 3 factors factor NNS cord-005453-4057qib7 9232 4 were be VBD cord-005453-4057qib7 9232 5 significantly significantly RB cord-005453-4057qib7 9232 6 associated associate VBN cord-005453-4057qib7 9232 7 to to IN cord-005453-4057qib7 9232 8 IFI IFI NNP cord-005453-4057qib7 9232 9 occurrence occurrence NN cord-005453-4057qib7 9232 10 . . . cord-005453-4057qib7 9233 1 Conclusions conclusion NNS cord-005453-4057qib7 9233 2 : : : cord-005453-4057qib7 9234 1 In in IN cord-005453-4057qib7 9234 2 our -PRON- PRP$ cord-005453-4057qib7 9234 3 experience experience NN cord-005453-4057qib7 9234 4 , , , cord-005453-4057qib7 9234 5 cumulative cumulative JJ cord-005453-4057qib7 9234 6 incidence incidence NN cord-005453-4057qib7 9234 7 of of IN cord-005453-4057qib7 9234 8 IFI IFI NNP cord-005453-4057qib7 9234 9 in in IN cord-005453-4057qib7 9234 10 the the DT cord-005453-4057qib7 9234 11 setting setting NN cord-005453-4057qib7 9234 12 of of IN cord-005453-4057qib7 9234 13 HaploSCT HaploSCT NNP cord-005453-4057qib7 9234 14 with with IN cord-005453-4057qib7 9234 15 posttransplant posttransplant NN cord-005453-4057qib7 9234 16 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 9234 17 was be VBD cord-005453-4057qib7 9234 18 similar similar JJ cord-005453-4057qib7 9234 19 than than IN cord-005453-4057qib7 9234 20 observed observed JJ cord-005453-4057qib7 9234 21 in in IN cord-005453-4057qib7 9234 22 previous previous JJ cord-005453-4057qib7 9234 23 studies study NNS cord-005453-4057qib7 9234 24 in in IN cord-005453-4057qib7 9234 25 alloSCT alloSCT NNP cord-005453-4057qib7 9234 26 . . . cord-005453-4057qib7 9235 1 Having have VBG cord-005453-4057qib7 9235 2 received receive VBN cord-005453-4057qib7 9235 3 a a DT cord-005453-4057qib7 9235 4 previous previous JJ cord-005453-4057qib7 9235 5 SCT SCT NNP cord-005453-4057qib7 9235 6 , , , cord-005453-4057qib7 9235 7 especially especially RB cord-005453-4057qib7 9235 8 alloSCT alloSCT NNP cord-005453-4057qib7 9235 9 , , , cord-005453-4057qib7 9235 10 was be VBD cord-005453-4057qib7 9235 11 the the DT cord-005453-4057qib7 9235 12 most most RBS cord-005453-4057qib7 9235 13 significant significant JJ cord-005453-4057qib7 9235 14 factor factor NN cord-005453-4057qib7 9235 15 related relate VBN cord-005453-4057qib7 9235 16 to to IN cord-005453-4057qib7 9235 17 IFI IFI NNP cord-005453-4057qib7 9235 18 development development NN cord-005453-4057qib7 9235 19 . . . cord-005453-4057qib7 9236 1 This this DT cord-005453-4057qib7 9236 2 high high JJ cord-005453-4057qib7 9236 3 risk risk NN cord-005453-4057qib7 9236 4 population population NN cord-005453-4057qib7 9236 5 should should MD cord-005453-4057qib7 9236 6 be be VB cord-005453-4057qib7 9236 7 closely closely RB cord-005453-4057qib7 9236 8 monitored monitor VBN cord-005453-4057qib7 9236 9 and and CC cord-005453-4057qib7 9236 10 could could MD cord-005453-4057qib7 9236 11 benefit benefit VB cord-005453-4057qib7 9236 12 from from IN cord-005453-4057qib7 9236 13 prophylaxis prophylaxis NN cord-005453-4057qib7 9236 14 with with IN cord-005453-4057qib7 9236 15 azoles azole NNS cord-005453-4057qib7 9236 16 . . . cord-005453-4057qib7 9237 1 Disclosure disclosure NN cord-005453-4057qib7 9237 2 : : : cord-005453-4057qib7 9237 3 Nothing nothing NN cord-005453-4057qib7 9237 4 to to TO cord-005453-4057qib7 9237 5 declare declare VB cord-005453-4057qib7 9237 6 . . . cord-005453-4057qib7 9238 1 Methods method NNS cord-005453-4057qib7 9238 2 : : : cord-005453-4057qib7 9239 1 RSV RSV NNP cord-005453-4057qib7 9239 2 infection infection NN cord-005453-4057qib7 9239 3 was be VBD cord-005453-4057qib7 9239 4 diagnosed diagnose VBN cord-005453-4057qib7 9239 5 in in IN cord-005453-4057qib7 9239 6 nasal nasal NN cord-005453-4057qib7 9239 7 wash wash NNP cord-005453-4057qib7 9239 8 ( ( -LRB- cord-005453-4057qib7 9239 9 NW NW NNP cord-005453-4057qib7 9239 10 ) ) -RRB- cord-005453-4057qib7 9239 11 or or CC cord-005453-4057qib7 9239 12 bronchoalveolar bronchoalveolar NNP cord-005453-4057qib7 9239 13 fluid fluid NN cord-005453-4057qib7 9239 14 ( ( -LRB- cord-005453-4057qib7 9239 15 BAL BAL NNP cord-005453-4057qib7 9239 16 ) ) -RRB- cord-005453-4057qib7 9239 17 by by IN cord-005453-4057qib7 9239 18 DFA DFA NNP cord-005453-4057qib7 9239 19 ( ( -LRB- cord-005453-4057qib7 9239 20 Millipore Millipore NNP cord-005453-4057qib7 9239 21 , , , cord-005453-4057qib7 9239 22 USA USA NNP cord-005453-4057qib7 9239 23 ) ) -RRB- cord-005453-4057qib7 9239 24 or or CC cord-005453-4057qib7 9239 25 PCR PCR NNP cord-005453-4057qib7 9239 26 ( ( -LRB- cord-005453-4057qib7 9239 27 Seeplex Seeplex NNP cord-005453-4057qib7 9239 28 , , , cord-005453-4057qib7 9239 29 Seegene Seegene NNP cord-005453-4057qib7 9239 30 , , , cord-005453-4057qib7 9239 31 KOR KOR NNP cord-005453-4057qib7 9239 32 ) ) -RRB- cord-005453-4057qib7 9239 33 . . . cord-005453-4057qib7 9240 1 URTI URTI NNP cord-005453-4057qib7 9240 2 and and CC cord-005453-4057qib7 9240 3 LRTI LRTI NNP cord-005453-4057qib7 9240 4 were be VBD cord-005453-4057qib7 9240 5 defined define VBN cord-005453-4057qib7 9240 6 according accord VBG cord-005453-4057qib7 9240 7 to to IN cord-005453-4057qib7 9240 8 ECIL-4 ECIL-4 NNP cord-005453-4057qib7 9240 9 guidelines guideline NNS cord-005453-4057qib7 9240 10 . . . cord-005453-4057qib7 9241 1 Death death NN cord-005453-4057qib7 9241 2 from from IN cord-005453-4057qib7 9241 3 all all DT cord-005453-4057qib7 9241 4 causes cause NNS cord-005453-4057qib7 9241 5 was be VBD cord-005453-4057qib7 9241 6 assessed assess VBN cord-005453-4057qib7 9241 7 within within IN cord-005453-4057qib7 9241 8 90 90 CD cord-005453-4057qib7 9241 9 days day NNS cord-005453-4057qib7 9241 10 after after IN cord-005453-4057qib7 9241 11 RSV RSV NNP cord-005453-4057qib7 9241 12 infection infection NN cord-005453-4057qib7 9241 13 and and CC cord-005453-4057qib7 9241 14 was be VBD cord-005453-4057qib7 9241 15 attributed attribute VBN cord-005453-4057qib7 9241 16 to to IN cord-005453-4057qib7 9241 17 RSV RSV NNP cord-005453-4057qib7 9241 18 if if IN cord-005453-4057qib7 9241 19 the the DT cord-005453-4057qib7 9241 20 patient patient NN cord-005453-4057qib7 9241 21 had have VBD cord-005453-4057qib7 9241 22 persistent persistent JJ cord-005453-4057qib7 9241 23 or or CC cord-005453-4057qib7 9241 24 progressive progressive JJ cord-005453-4057qib7 9241 25 RSV rsv NN cord-005453-4057qib7 9241 26 infection infection NN cord-005453-4057qib7 9241 27 with with IN cord-005453-4057qib7 9241 28 respiratory respiratory JJ cord-005453-4057qib7 9241 29 failure failure NN cord-005453-4057qib7 9241 30 at at IN cord-005453-4057qib7 9241 31 the the DT cord-005453-4057qib7 9241 32 time time NN cord-005453-4057qib7 9241 33 of of IN cord-005453-4057qib7 9241 34 death death NN cord-005453-4057qib7 9241 35 . . . cord-005453-4057qib7 9242 1 Neutropenia neutropenia NN cord-005453-4057qib7 9242 2 and and CC cord-005453-4057qib7 9242 3 lymphocytopenia lymphocytopenia NNP cord-005453-4057qib7 9242 4 were be VBD cord-005453-4057qib7 9242 5 defined define VBN cord-005453-4057qib7 9242 6 as as IN cord-005453-4057qib7 9242 7 an an DT cord-005453-4057qib7 9242 8 absolute absolute JJ cord-005453-4057qib7 9242 9 neutrophil neutrophil NN cord-005453-4057qib7 9242 10 count count NN cord-005453-4057qib7 9242 11 ( ( -LRB- cord-005453-4057qib7 9242 12 ANC ANC NNP cord-005453-4057qib7 9242 13 ) ) -RRB- cord-005453-4057qib7 9242 14 < < XX cord-005453-4057qib7 9243 1 500 500 CD cord-005453-4057qib7 9243 2 / / SYM cord-005453-4057qib7 9243 3 uL ul NN cord-005453-4057qib7 9243 4 and and CC cord-005453-4057qib7 9243 5 absolute absolute JJ cord-005453-4057qib7 9243 6 lymphocyte lymphocyte NN cord-005453-4057qib7 9243 7 count count NN cord-005453-4057qib7 9243 8 ( ( -LRB- cord-005453-4057qib7 9243 9 ALC ALC NNP cord-005453-4057qib7 9243 10 ) ) -RRB- cord-005453-4057qib7 9244 1 < < NNP cord-005453-4057qib7 9244 2 200 200 CD cord-005453-4057qib7 9244 3 / / SYM cord-005453-4057qib7 9244 4 uL ul NN cord-005453-4057qib7 9244 5 , , , cord-005453-4057qib7 9244 6 respectively respectively RB cord-005453-4057qib7 9244 7 . . . cord-005453-4057qib7 9245 1 Results result NNS cord-005453-4057qib7 9245 2 : : : cord-005453-4057qib7 9246 1 Median median JJ cord-005453-4057qib7 9246 2 number number NN cord-005453-4057qib7 9246 3 of of IN cord-005453-4057qib7 9246 4 confirmed confirm VBN cord-005453-4057qib7 9246 5 RSV RSV NNP cord-005453-4057qib7 9246 6 infections infection NNS cord-005453-4057qib7 9246 7 per per IN cord-005453-4057qib7 9246 8 year year NN cord-005453-4057qib7 9246 9 was be VBD cord-005453-4057qib7 9246 10 12 12 CD cord-005453-4057qib7 9246 11 , , , cord-005453-4057qib7 9246 12 ranging range VBG cord-005453-4057qib7 9246 13 from from IN cord-005453-4057qib7 9246 14 5 5 CD cord-005453-4057qib7 9246 15 to to IN cord-005453-4057qib7 9246 16 34 34 CD cord-005453-4057qib7 9246 17 . . . cord-005453-4057qib7 9247 1 An an DT cord-005453-4057qib7 9247 2 outbreak outbreak NN cord-005453-4057qib7 9247 3 of of IN cord-005453-4057qib7 9247 4 RSV RSV NNP cord-005453-4057qib7 9247 5 was be VBD cord-005453-4057qib7 9247 6 detected detect VBN cord-005453-4057qib7 9247 7 in in IN cord-005453-4057qib7 9247 8 2017 2017 CD cord-005453-4057qib7 9247 9 , , , cord-005453-4057qib7 9247 10 possibly possibly RB cord-005453-4057qib7 9247 11 due due IN cord-005453-4057qib7 9247 12 to to IN cord-005453-4057qib7 9247 13 a a DT cord-005453-4057qib7 9247 14 lack lack NN cord-005453-4057qib7 9247 15 of of IN cord-005453-4057qib7 9247 16 compliance compliance NN cord-005453-4057qib7 9247 17 with with IN cord-005453-4057qib7 9247 18 contact contact NN cord-005453-4057qib7 9247 19 precautions precaution NNS cord-005453-4057qib7 9247 20 in in IN cord-005453-4057qib7 9247 21 the the DT cord-005453-4057qib7 9247 22 unit unit NN cord-005453-4057qib7 9247 23 . . . cord-005453-4057qib7 9248 1 Median median JJ cord-005453-4057qib7 9248 2 patients patient NNS cord-005453-4057qib7 9248 3 ' ' POS cord-005453-4057qib7 9248 4 age age NN cord-005453-4057qib7 9248 5 was be VBD cord-005453-4057qib7 9248 6 26 26 CD cord-005453-4057qib7 9248 7 years year NNS cord-005453-4057qib7 9248 8 and and CC cord-005453-4057qib7 9248 9 time time NN cord-005453-4057qib7 9248 10 to to IN cord-005453-4057qib7 9248 11 RSV RSV NNP cord-005453-4057qib7 9248 12 infection infection NN cord-005453-4057qib7 9249 1 was be VBD cord-005453-4057qib7 9249 2 day day NN cord-005453-4057qib7 9249 3 80 80 CD cord-005453-4057qib7 9249 4 ( ( -LRB- cord-005453-4057qib7 9249 5 -11 -11 '' cord-005453-4057qib7 9249 6 to to IN cord-005453-4057qib7 9249 7 1837 1837 CD cord-005453-4057qib7 9249 8 ) ) -RRB- cord-005453-4057qib7 9249 9 . . . cord-005453-4057qib7 9250 1 Twenty twenty CD cord-005453-4057qib7 9250 2 - - HYPH cord-005453-4057qib7 9250 3 three three CD cord-005453-4057qib7 9250 4 patients patient NNS cord-005453-4057qib7 9250 5 ( ( -LRB- cord-005453-4057qib7 9250 6 pts pt NNS cord-005453-4057qib7 9250 7 ) ) -RRB- cord-005453-4057qib7 9250 8 had have VBD cord-005453-4057qib7 9250 9 received receive VBN cord-005453-4057qib7 9250 10 an an DT cord-005453-4057qib7 9250 11 autologous autologous JJ cord-005453-4057qib7 9250 12 transplantation transplantation NN cord-005453-4057qib7 9250 13 ( ( -LRB- cord-005453-4057qib7 9250 14 17.2 17.2 CD cord-005453-4057qib7 9250 15 % % NN cord-005453-4057qib7 9250 16 ) ) -RRB- cord-005453-4057qib7 9250 17 and and CC cord-005453-4057qib7 9250 18 111 111 CD cord-005453-4057qib7 9250 19 were be VBD cord-005453-4057qib7 9250 20 allogeneic allogeneic VBN cord-005453-4057qib7 9250 21 HSCT HSCT NNP cord-005453-4057qib7 9250 22 recipients recipient NNS cord-005453-4057qib7 9250 23 ( ( -LRB- cord-005453-4057qib7 9250 24 82,8 82,8 CD cord-005453-4057qib7 9250 25 % % NN cord-005453-4057qib7 9250 26 ) ) -RRB- cord-005453-4057qib7 9250 27 . . . cord-005453-4057qib7 9251 1 Median median JJ cord-005453-4057qib7 9251 2 time time NN cord-005453-4057qib7 9251 3 to to IN cord-005453-4057qib7 9251 4 engraftment engraftment NN cord-005453-4057qib7 9251 5 was be VBD cord-005453-4057qib7 9251 6 15 15 CD cord-005453-4057qib7 9251 7 days day NNS cord-005453-4057qib7 9251 8 , , , cord-005453-4057qib7 9251 9 ranging range VBG cord-005453-4057qib7 9251 10 from from IN cord-005453-4057qib7 9251 11 10 10 CD cord-005453-4057qib7 9251 12 to to TO cord-005453-4057qib7 9251 13 27 27 CD cord-005453-4057qib7 9251 14 days day NNS cord-005453-4057qib7 9251 15 . . . cord-005453-4057qib7 9252 1 At at IN cord-005453-4057qib7 9252 2 RSV RSV NNP cord-005453-4057qib7 9252 3 diagnosis diagnosis NN cord-005453-4057qib7 9252 4 , , , cord-005453-4057qib7 9252 5 108 108 CD cord-005453-4057qib7 9252 6 pts pt NNS cord-005453-4057qib7 9252 7 presented present VBN cord-005453-4057qib7 9252 8 with with IN cord-005453-4057qib7 9252 9 URTI URTI NNP cord-005453-4057qib7 9252 10 ( ( -LRB- cord-005453-4057qib7 9252 11 80.6 80.6 CD cord-005453-4057qib7 9252 12 % % NN cord-005453-4057qib7 9252 13 ) ) -RRB- cord-005453-4057qib7 9252 14 and and CC cord-005453-4057qib7 9252 15 26 26 CD cord-005453-4057qib7 9252 16 with with IN cord-005453-4057qib7 9252 17 LRTI LRTI NNP cord-005453-4057qib7 9252 18 ( ( -LRB- cord-005453-4057qib7 9252 19 19.4 19.4 CD cord-005453-4057qib7 9252 20 ) ) -RRB- cord-005453-4057qib7 9252 21 . . . cord-005453-4057qib7 9253 1 Surprisingly surprisingly RB cord-005453-4057qib7 9253 2 , , , cord-005453-4057qib7 9253 3 around around IN cord-005453-4057qib7 9253 4 18 18 CD cord-005453-4057qib7 9253 5 % % NN cord-005453-4057qib7 9253 6 of of IN cord-005453-4057qib7 9253 7 the the DT cord-005453-4057qib7 9253 8 auto auto NN cord-005453-4057qib7 9253 9 HSCT HSCT NNP cord-005453-4057qib7 9253 10 recipients recipient NNS cord-005453-4057qib7 9253 11 had have VBD cord-005453-4057qib7 9253 12 RSV RSV NNP cord-005453-4057qib7 9253 13 pneumonia pneumonia NN cord-005453-4057qib7 9253 14 at at IN cord-005453-4057qib7 9253 15 diagnosis diagnosis NN cord-005453-4057qib7 9253 16 . . . cord-005453-4057qib7 9254 1 Variables variable NNS cord-005453-4057qib7 9254 2 significantly significantly RB cord-005453-4057qib7 9254 3 associated associate VBD cord-005453-4057qib7 9254 4 with with IN cord-005453-4057qib7 9254 5 LRTI LRTI NNS cord-005453-4057qib7 9254 6 at at IN cord-005453-4057qib7 9254 7 diagnosis diagnosis NN cord-005453-4057qib7 9254 8 were be VBD cord-005453-4057qib7 9254 9 MUD mud NN cord-005453-4057qib7 9254 10 HSCT HSCT NNP cord-005453-4057qib7 9254 11 ( ( -LRB- cord-005453-4057qib7 9255 1 No/ No/ NNP cord-005453-4057qib7 9255 2 Yes yes UH cord-005453-4057qib7 9255 3 , , , cord-005453-4057qib7 9255 4 OR or CC cord-005453-4057qib7 9255 5 0.42 0.42 CD cord-005453-4057qib7 9255 6 ; ; : cord-005453-4057qib7 9255 7 CI95 CI95 NNP cord-005453-4057qib7 9255 8 0.20 0.20 CD cord-005453-4057qib7 9255 9 - - HYPH cord-005453-4057qib7 9255 10 0.89 0.89 CD cord-005453-4057qib7 9255 11 ) ) -RRB- cord-005453-4057qib7 9255 12 ; ; : cord-005453-4057qib7 9255 13 ANC ANC NNP cord-005453-4057qib7 9255 14 < < XX cord-005453-4057qib7 9255 15 500 500 CD cord-005453-4057qib7 9256 1 /uL /uL NFP cord-005453-4057qib7 9256 2 ( ( -LRB- cord-005453-4057qib7 9256 3 OR or CC cord-005453-4057qib7 9256 4 2.75 2.75 CD cord-005453-4057qib7 9256 5 ; ; : cord-005453-4057qib7 9256 6 CI95 CI95 NNP cord-005453-4057qib7 9256 7 1.01 1.01 CD cord-005453-4057qib7 9256 8 - - SYM cord-005453-4057qib7 9256 9 7.45 7.45 CD cord-005453-4057qib7 9256 10 ) ) -RRB- cord-005453-4057qib7 9257 1 ; ; : cord-005453-4057qib7 9257 2 ALC ALC NNP cord-005453-4057qib7 9257 3 < < XX cord-005453-4057qib7 9257 4 200 200 CD cord-005453-4057qib7 9257 5 / / SYM cord-005453-4057qib7 9257 6 uL ul NN cord-005453-4057qib7 9257 7 ( ( -LRB- cord-005453-4057qib7 9257 8 OR or CC cord-005453-4057qib7 9257 9 3.25 3.25 CD cord-005453-4057qib7 9257 10 ; ; : cord-005453-4057qib7 9257 11 CI95 CI95 NNP cord-005453-4057qib7 9257 12 1.12 1.12 CD cord-005453-4057qib7 9257 13 - - HYPH cord-005453-4057qib7 9257 14 9.45 9.45 CD cord-005453-4057qib7 9257 15 ) ) -RRB- cord-005453-4057qib7 9257 16 ; ; : cord-005453-4057qib7 9257 17 and and CC cord-005453-4057qib7 9257 18 recent recent JJ cord-005453-4057qib7 9257 19 or or CC cord-005453-4057qib7 9257 20 pre pre JJ cord-005453-4057qib7 9257 21 - - JJ cord-005453-4057qib7 9257 22 engraftment engraftment JJ cord-005453-4057qib7 9257 23 HSCT HSCT NNP cord-005453-4057qib7 9257 24 ( ( -LRB- cord-005453-4057qib7 9257 25 No/ No/ NNP cord-005453-4057qib7 9258 1 Yes yes UH cord-005453-4057qib7 9258 2 , , , cord-005453-4057qib7 9258 3 OR or CC cord-005453-4057qib7 9258 4 0.38 0.38 CD cord-005453-4057qib7 9258 5 CI9 CI9 NNP cord-005453-4057qib7 9258 6 0.14 0.14 CD cord-005453-4057qib7 9258 7 - - SYM cord-005453-4057qib7 9258 8 0.98 0.98 CD cord-005453-4057qib7 9258 9 ) ) -RRB- cord-005453-4057qib7 9258 10 . . . cord-005453-4057qib7 9259 1 Among among IN cord-005453-4057qib7 9259 2 the the DT cord-005453-4057qib7 9259 3 108 108 CD cord-005453-4057qib7 9259 4 pts pt NNS cord-005453-4057qib7 9259 5 with with IN cord-005453-4057qib7 9259 6 URTI URTI NNP cord-005453-4057qib7 9259 7 at at IN cord-005453-4057qib7 9259 8 diagnosis diagnosis NN cord-005453-4057qib7 9259 9 , , , cord-005453-4057qib7 9259 10 19 19 CD cord-005453-4057qib7 9259 11 progressed progress VBD cord-005453-4057qib7 9259 12 to to IN cord-005453-4057qib7 9259 13 LRTI LRTI NNP cord-005453-4057qib7 9259 14 ( ( -LRB- cord-005453-4057qib7 9259 15 17.6 17.6 CD cord-005453-4057qib7 9259 16 % % NN cord-005453-4057qib7 9259 17 ) ) -RRB- cord-005453-4057qib7 9259 18 . . . cord-005453-4057qib7 9260 1 Forty forty CD cord-005453-4057qib7 9260 2 - - HYPH cord-005453-4057qib7 9260 3 four four CD cord-005453-4057qib7 9260 4 of of IN cord-005453-4057qib7 9260 5 the the DT cord-005453-4057qib7 9260 6 134 134 CD cord-005453-4057qib7 9260 7 pts pt NNS cord-005453-4057qib7 9260 8 died die VBD cord-005453-4057qib7 9260 9 ( ( -LRB- cord-005453-4057qib7 9260 10 32.8 32.8 CD cord-005453-4057qib7 9260 11 % % NN cord-005453-4057qib7 9260 12 ) ) -RRB- cord-005453-4057qib7 9260 13 and and CC cord-005453-4057qib7 9260 14 mortality mortality NN cord-005453-4057qib7 9260 15 rate rate NN cord-005453-4057qib7 9260 16 was be VBD cord-005453-4057qib7 9260 17 significantly significantly RB cord-005453-4057qib7 9260 18 higher high JJR cord-005453-4057qib7 9260 19 in in IN cord-005453-4057qib7 9260 20 pts pts NN cord-005453-4057qib7 9260 21 with with IN cord-005453-4057qib7 9260 22 LRTI LRTI NNS cord-005453-4057qib7 9260 23 in in IN cord-005453-4057qib7 9260 24 comparison comparison NN cord-005453-4057qib7 9260 25 with with IN cord-005453-4057qib7 9260 26 pts pt NNS cord-005453-4057qib7 9260 27 with with IN cord-005453-4057qib7 9260 28 URTI URTI NNP cord-005453-4057qib7 9260 29 ( ( -LRB- cord-005453-4057qib7 9260 30 53.8 53.8 CD cord-005453-4057qib7 9260 31 % % NN cord-005453-4057qib7 9260 32 versus versus IN cord-005453-4057qib7 9260 33 27.8 27.8 CD cord-005453-4057qib7 9260 34 % % NN cord-005453-4057qib7 9260 35 , , , cord-005453-4057qib7 9260 36 p=0.011 p=0.011 NNP cord-005453-4057qib7 9260 37 ) ) -RRB- cord-005453-4057qib7 9260 38 . . . cord-005453-4057qib7 9261 1 Death death NN cord-005453-4057qib7 9261 2 was be VBD cord-005453-4057qib7 9261 3 attributed attribute VBN cord-005453-4057qib7 9261 4 to to IN cord-005453-4057qib7 9261 5 RSV RSV NNP cord-005453-4057qib7 9261 6 in in IN cord-005453-4057qib7 9261 7 11 11 CD cord-005453-4057qib7 9261 8 of of IN cord-005453-4057qib7 9261 9 the the DT cord-005453-4057qib7 9261 10 44 44 CD cord-005453-4057qib7 9261 11 pts pt NNS cord-005453-4057qib7 9261 12 who who WP cord-005453-4057qib7 9261 13 died die VBD cord-005453-4057qib7 9261 14 ( ( -LRB- cord-005453-4057qib7 9261 15 25 25 CD cord-005453-4057qib7 9261 16 % % NN cord-005453-4057qib7 9261 17 ) ) -RRB- cord-005453-4057qib7 9261 18 . . . cord-005453-4057qib7 9262 1 Conclusions conclusion NNS cord-005453-4057qib7 9262 2 : : : cord-005453-4057qib7 9263 1 Autologous autologous JJ cord-005453-4057qib7 9263 2 HSCT HSCT NNP cord-005453-4057qib7 9263 3 recipients recipient NNS cord-005453-4057qib7 9263 4 are be VBP cord-005453-4057qib7 9263 5 also also RB cord-005453-4057qib7 9263 6 at at IN cord-005453-4057qib7 9263 7 risk risk NN cord-005453-4057qib7 9263 8 of of IN cord-005453-4057qib7 9263 9 LRTI LRTI NNS cord-005453-4057qib7 9263 10 caused cause VBN cord-005453-4057qib7 9263 11 by by IN cord-005453-4057qib7 9263 12 RSV RSV NNP cord-005453-4057qib7 9263 13 . . . cord-005453-4057qib7 9264 1 Risk risk NN cord-005453-4057qib7 9264 2 of of IN cord-005453-4057qib7 9264 3 RSV RSV NNP cord-005453-4057qib7 9264 4 LRTI LRTI NNP cord-005453-4057qib7 9264 5 is be VBZ cord-005453-4057qib7 9264 6 higher high JJR cord-005453-4057qib7 9264 7 in in IN cord-005453-4057qib7 9264 8 MUD mud NN cord-005453-4057qib7 9264 9 HSCT HSCT NNP cord-005453-4057qib7 9264 10 , , , cord-005453-4057qib7 9264 11 infection infection NN cord-005453-4057qib7 9264 12 acquired acquire VBD cord-005453-4057qib7 9264 13 pre pre NN cord-005453-4057qib7 9264 14 - - NN cord-005453-4057qib7 9264 15 engraftment engraftment JJ cord-005453-4057qib7 9264 16 or or CC cord-005453-4057qib7 9264 17 early early RB cord-005453-4057qib7 9264 18 after after IN cord-005453-4057qib7 9264 19 HSCT HSCT NNP cord-005453-4057qib7 9264 20 , , , cord-005453-4057qib7 9264 21 and and CC cord-005453-4057qib7 9264 22 low low JJ cord-005453-4057qib7 9264 23 neutrophil neutrophil NN cord-005453-4057qib7 9264 24 and and CC cord-005453-4057qib7 9264 25 lymphocyte lymphocyte NN cord-005453-4057qib7 9264 26 counts count NNS cord-005453-4057qib7 9264 27 . . . cord-005453-4057qib7 9265 1 Continued continued JJ cord-005453-4057qib7 9265 2 education education NN cord-005453-4057qib7 9265 3 is be VBZ cord-005453-4057qib7 9265 4 necessary necessary JJ cord-005453-4057qib7 9265 5 to to TO cord-005453-4057qib7 9265 6 sustain sustain VB cord-005453-4057qib7 9265 7 compliance compliance NN cord-005453-4057qib7 9265 8 to to IN cord-005453-4057qib7 9265 9 contact contact VB cord-005453-4057qib7 9265 10 precautions precaution NNS cord-005453-4057qib7 9265 11 in in IN cord-005453-4057qib7 9265 12 HSCT HSCT NNP cord-005453-4057qib7 9265 13 units unit NNS cord-005453-4057qib7 9265 14 . . . cord-005453-4057qib7 9266 1 Disclosure disclosure NN cord-005453-4057qib7 9266 2 Background background NN cord-005453-4057qib7 9266 3 : : : cord-005453-4057qib7 9267 1 Measles measles NN cord-005453-4057qib7 9267 2 is be VBZ cord-005453-4057qib7 9267 3 a a DT cord-005453-4057qib7 9267 4 life life NN cord-005453-4057qib7 9267 5 - - HYPH cord-005453-4057qib7 9267 6 threatening threaten VBG cord-005453-4057qib7 9267 7 infection infection NN cord-005453-4057qib7 9267 8 after after IN cord-005453-4057qib7 9267 9 allogeneic allogeneic NN cord-005453-4057qib7 9267 10 HCT hct NN cord-005453-4057qib7 9267 11 . . . cord-005453-4057qib7 9268 1 Due due IN cord-005453-4057qib7 9268 2 to to IN cord-005453-4057qib7 9268 3 the the DT cord-005453-4057qib7 9268 4 decreased decrease VBN cord-005453-4057qib7 9268 5 coverage coverage NN cord-005453-4057qib7 9268 6 of of IN cord-005453-4057qib7 9268 7 vaccination vaccination NN cord-005453-4057qib7 9268 8 in in IN cord-005453-4057qib7 9268 9 many many JJ cord-005453-4057qib7 9268 10 countries country NNS cord-005453-4057qib7 9268 11 , , , cord-005453-4057qib7 9268 12 the the DT cord-005453-4057qib7 9268 13 disease disease NN cord-005453-4057qib7 9268 14 reappears reappear VBZ cord-005453-4057qib7 9268 15 , , , cord-005453-4057qib7 9268 16 increasing increase VBG cord-005453-4057qib7 9268 17 the the DT cord-005453-4057qib7 9268 18 risk risk NN cord-005453-4057qib7 9268 19 of of IN cord-005453-4057qib7 9268 20 outbreaks outbreak NNS cord-005453-4057qib7 9268 21 worldwide worldwide RB cord-005453-4057qib7 9268 22 . . . cord-005453-4057qib7 9269 1 Allogeneic allogeneic IN cord-005453-4057qib7 9269 2 HCT hct NN cord-005453-4057qib7 9269 3 recipients recipient NNS cord-005453-4057qib7 9269 4 have have VBP cord-005453-4057qib7 9269 5 been be VBN cord-005453-4057qib7 9269 6 shown show VBN cord-005453-4057qib7 9269 7 to to TO cord-005453-4057qib7 9269 8 be be VB cord-005453-4057qib7 9269 9 seropositive seropositive JJ cord-005453-4057qib7 9269 10 for for IN cord-005453-4057qib7 9269 11 measles measle NNS cord-005453-4057qib7 9269 12 in in IN cord-005453-4057qib7 9269 13 roughly roughly RB cord-005453-4057qib7 9269 14 40 40 CD cord-005453-4057qib7 9269 15 - - SYM cord-005453-4057qib7 9269 16 50 50 CD cord-005453-4057qib7 9269 17 % % NN cord-005453-4057qib7 9269 18 of of IN cord-005453-4057qib7 9269 19 the the DT cord-005453-4057qib7 9269 20 cases case NNS cord-005453-4057qib7 9269 21 3 3 CD cord-005453-4057qib7 9269 22 years year NNS cord-005453-4057qib7 9269 23 after after IN cord-005453-4057qib7 9269 24 transplant transplant NN cord-005453-4057qib7 9269 25 . . . cord-005453-4057qib7 9270 1 However however RB cord-005453-4057qib7 9270 2 , , , cord-005453-4057qib7 9270 3 these these DT cord-005453-4057qib7 9270 4 data datum NNS cord-005453-4057qib7 9270 5 were be VBD cord-005453-4057qib7 9270 6 obtained obtain VBN cord-005453-4057qib7 9270 7 before before IN cord-005453-4057qib7 9270 8 the the DT cord-005453-4057qib7 9270 9 2000 2000 CD cord-005453-4057qib7 9270 10 's 's POS cord-005453-4057qib7 9270 11 from from IN cord-005453-4057qib7 9270 12 HCT HCT NNP cord-005453-4057qib7 9270 13 populations population NNS cord-005453-4057qib7 9270 14 mainly mainly RB cord-005453-4057qib7 9270 15 conditioned condition VBN cord-005453-4057qib7 9270 16 with with IN cord-005453-4057qib7 9270 17 myeloablative myeloablative NNP cord-005453-4057qib7 9270 18 ( ( -LRB- cord-005453-4057qib7 9270 19 MA MA NNP cord-005453-4057qib7 9270 20 ) ) -RRB- cord-005453-4057qib7 9270 21 regimens regimen NNS cord-005453-4057qib7 9270 22 . . . cord-005453-4057qib7 9271 1 Our -PRON- PRP$ cord-005453-4057qib7 9271 2 aim aim NN cord-005453-4057qib7 9271 3 was be VBD cord-005453-4057qib7 9271 4 to to TO cord-005453-4057qib7 9271 5 assess assess VB cord-005453-4057qib7 9271 6 measles measles NN cord-005453-4057qib7 9271 7 immunity immunity NN cord-005453-4057qib7 9271 8 before before IN cord-005453-4057qib7 9271 9 considering consider VBG cord-005453-4057qib7 9271 10 vaccination vaccination NN cord-005453-4057qib7 9271 11 in in IN cord-005453-4057qib7 9271 12 a a DT cord-005453-4057qib7 9271 13 cohort cohort NN cord-005453-4057qib7 9271 14 of of IN cord-005453-4057qib7 9271 15 HCT HCT NNP cord-005453-4057qib7 9271 16 survivors survivor NNS cord-005453-4057qib7 9271 17 including include VBG cord-005453-4057qib7 9271 18 patients patient NNS cord-005453-4057qib7 9271 19 conditioned condition VBN cord-005453-4057qib7 9271 20 with with IN cord-005453-4057qib7 9271 21 reduced reduce VBN cord-005453-4057qib7 9271 22 intensity intensity NN cord-005453-4057qib7 9271 23 ( ( -LRB- cord-005453-4057qib7 9271 24 RIC RIC NNP cord-005453-4057qib7 9271 25 ) ) -RRB- cord-005453-4057qib7 9271 26 or or CC cord-005453-4057qib7 9271 27 non non JJ cord-005453-4057qib7 9271 28 - - JJ cord-005453-4057qib7 9271 29 MA ma JJ cord-005453-4057qib7 9271 30 regimens regimen NNS cord-005453-4057qib7 9271 31 . . . cord-005453-4057qib7 9272 1 Methods method NNS cord-005453-4057qib7 9272 2 : : : cord-005453-4057qib7 9272 3 Allogeneic Allogeneic NNP cord-005453-4057qib7 9272 4 HCT hct NN cord-005453-4057qib7 9272 5 adult adult NN cord-005453-4057qib7 9272 6 recipients recipient NNS cord-005453-4057qib7 9272 7 who who WP cord-005453-4057qib7 9272 8 had have VBD cord-005453-4057qib7 9272 9 not not RB cord-005453-4057qib7 9272 10 been be VBN cord-005453-4057qib7 9272 11 vaccinated vaccinate VBN cord-005453-4057qib7 9272 12 for for IN cord-005453-4057qib7 9272 13 measles measle NNS cord-005453-4057qib7 9272 14 since since IN cord-005453-4057qib7 9272 15 HCT HCT NNP cord-005453-4057qib7 9272 16 were be VBD cord-005453-4057qib7 9272 17 routinely routinely RB cord-005453-4057qib7 9272 18 screened screen VBN cord-005453-4057qib7 9272 19 for for IN cord-005453-4057qib7 9272 20 measles measles NN cord-005453-4057qib7 9272 21 immunity immunity NN cord-005453-4057qib7 9272 22 . . . cord-005453-4057qib7 9273 1 Measles measles JJ cord-005453-4057qib7 9273 2 IgG igg NN cord-005453-4057qib7 9273 3 titers titer NNS cord-005453-4057qib7 9273 4 were be VBD cord-005453-4057qib7 9273 5 determined determine VBN cord-005453-4057qib7 9273 6 with with IN cord-005453-4057qib7 9273 7 a a DT cord-005453-4057qib7 9273 8 chemiluminescence chemiluminescence NN cord-005453-4057qib7 9273 9 immunoassay immunoassay NN cord-005453-4057qib7 9273 10 ( ( -LRB- cord-005453-4057qib7 9273 11 Liaison Liaison NNP cord-005453-4057qib7 9273 12 Measles Measles NNP cord-005453-4057qib7 9273 13 IgG igg NN cord-005453-4057qib7 9273 14 Kit kit NN cord-005453-4057qib7 9273 15 , , , cord-005453-4057qib7 9273 16 Liaison Liaison NNP cord-005453-4057qib7 9273 17 XL XL NNP cord-005453-4057qib7 9273 18 analyser analyser NN cord-005453-4057qib7 9273 19 , , , cord-005453-4057qib7 9273 20 Diasorin Diasorin NNP cord-005453-4057qib7 9273 21 , , , cord-005453-4057qib7 9273 22 Italy Italy NNP cord-005453-4057qib7 9273 23 ) ) -RRB- cord-005453-4057qib7 9273 24 . . . cord-005453-4057qib7 9274 1 Patients patient NNS cord-005453-4057qib7 9274 2 were be VBD cord-005453-4057qib7 9274 3 considered consider VBN cord-005453-4057qib7 9274 4 to to TO cord-005453-4057qib7 9274 5 be be VB cord-005453-4057qib7 9274 6 seropositive seropositive JJ cord-005453-4057qib7 9274 7 if if IN cord-005453-4057qib7 9274 8 the the DT cord-005453-4057qib7 9274 9 IgG IgG NNP cord-005453-4057qib7 9274 10 titer titer NN cord-005453-4057qib7 9274 11 was be VBD cord-005453-4057qib7 9274 12 > > NFP cord-005453-4057qib7 9274 13 16.5 16.5 CD cord-005453-4057qib7 9274 14 UA UA NNP cord-005453-4057qib7 9274 15 / / SYM cord-005453-4057qib7 9274 16 mL. mL. NNP cord-005453-4057qib7 9274 17 Risk risk NN cord-005453-4057qib7 9274 18 factors factor NNS cord-005453-4057qib7 9274 19 for for IN cord-005453-4057qib7 9274 20 seropositivity seropositivity NN cord-005453-4057qib7 9274 21 were be VBD cord-005453-4057qib7 9274 22 analyzed analyze VBN cord-005453-4057qib7 9274 23 . . . cord-005453-4057qib7 9275 1 Qualitative qualitative JJ cord-005453-4057qib7 9275 2 variables variable NNS cord-005453-4057qib7 9275 3 were be VBD cord-005453-4057qib7 9275 4 described describe VBN cord-005453-4057qib7 9275 5 as as IN cord-005453-4057qib7 9275 6 numbers number NNS cord-005453-4057qib7 9275 7 ( ( -LRB- cord-005453-4057qib7 9275 8 % % NN cord-005453-4057qib7 9275 9 ) ) -RRB- cord-005453-4057qib7 9275 10 and and CC cord-005453-4057qib7 9275 11 compared compare VBN cord-005453-4057qib7 9275 12 using use VBG cord-005453-4057qib7 9275 13 the the DT cord-005453-4057qib7 9275 14 chi-2 chi-2 NNP cord-005453-4057qib7 9275 15 test test NN cord-005453-4057qib7 9275 16 or or CC cord-005453-4057qib7 9275 17 Fisher Fisher NNP cord-005453-4057qib7 9275 18 exact exact JJ cord-005453-4057qib7 9275 19 test test NN cord-005453-4057qib7 9275 20 as as IN cord-005453-4057qib7 9275 21 appropriate appropriate JJ cord-005453-4057qib7 9275 22 . . . cord-005453-4057qib7 9276 1 Quantitative quantitative JJ cord-005453-4057qib7 9276 2 variables variable NNS cord-005453-4057qib7 9276 3 were be VBD cord-005453-4057qib7 9276 4 described describe VBN cord-005453-4057qib7 9276 5 as as IN cord-005453-4057qib7 9276 6 median median NN cord-005453-4057qib7 9276 7 or or CC cord-005453-4057qib7 9276 8 mean mean JJ cord-005453-4057qib7 9276 9 ( ( -LRB- cord-005453-4057qib7 9276 10 range range NN cord-005453-4057qib7 9276 11 ) ) -RRB- cord-005453-4057qib7 9276 12 and and CC cord-005453-4057qib7 9276 13 compared compare VBN cord-005453-4057qib7 9276 14 using use VBG cord-005453-4057qib7 9276 15 the the DT cord-005453-4057qib7 9276 16 Kruskall Kruskall NNP cord-005453-4057qib7 9276 17 - - HYPH cord-005453-4057qib7 9276 18 Wallis Wallis NNP cord-005453-4057qib7 9276 19 test test NN cord-005453-4057qib7 9276 20 . . . cord-005453-4057qib7 9277 1 ORs or NNS cord-005453-4057qib7 9277 2 were be VBD cord-005453-4057qib7 9277 3 estimated estimate VBN cord-005453-4057qib7 9277 4 separately separately RB cord-005453-4057qib7 9277 5 for for IN cord-005453-4057qib7 9277 6 factor factor NN cord-005453-4057qib7 9277 7 yielding yield VBG cord-005453-4057qib7 9277 8 a a DT cord-005453-4057qib7 9277 9 P p NN cord-005453-4057qib7 9277 10 - - HYPH cord-005453-4057qib7 9277 11 value value NN cord-005453-4057qib7 9277 12 < < XX cord-005453-4057qib7 9277 13 0.20 0.20 CD cord-005453-4057qib7 9277 14 in in IN cord-005453-4057qib7 9277 15 the the DT cord-005453-4057qib7 9277 16 univariate univariate JJ cord-005453-4057qib7 9277 17 analysis analysis NN cord-005453-4057qib7 9277 18 using use VBG cord-005453-4057qib7 9277 19 logistic logistic JJ cord-005453-4057qib7 9277 20 regression regression NN cord-005453-4057qib7 9277 21 models model NNS cord-005453-4057qib7 9277 22 . . . cord-005453-4057qib7 9278 1 Results result NNS cord-005453-4057qib7 9278 2 : : : cord-005453-4057qib7 9279 1 Eighty eighty CD cord-005453-4057qib7 9279 2 - - HYPH cord-005453-4057qib7 9279 3 six six CD cord-005453-4057qib7 9279 4 patients patient NNS cord-005453-4057qib7 9279 5 , , , cord-005453-4057qib7 9279 6 transplanted transplant VBD cord-005453-4057qib7 9279 7 1.5 1.5 CD cord-005453-4057qib7 9279 8 to to TO cord-005453-4057qib7 9279 9 38 38 CD cord-005453-4057qib7 9279 10 years year NNS cord-005453-4057qib7 9279 11 ( ( -LRB- cord-005453-4057qib7 9279 12 mean mean VB cord-005453-4057qib7 9279 13 : : : cord-005453-4057qib7 9279 14 13,5 13,5 CD cord-005453-4057qib7 9279 15 years year NNS cord-005453-4057qib7 9279 16 ) ) -RRB- cord-005453-4057qib7 9279 17 ago ago RB cord-005453-4057qib7 9279 18 , , , cord-005453-4057qib7 9279 19 were be VBD cord-005453-4057qib7 9279 20 included include VBN cord-005453-4057qib7 9279 21 . . . cord-005453-4057qib7 9280 1 The the DT cord-005453-4057qib7 9280 2 mean mean JJ cord-005453-4057qib7 9280 3 age age NN cord-005453-4057qib7 9280 4 was be VBD cord-005453-4057qib7 9280 5 53 53 CD cord-005453-4057qib7 9280 6 years year NNS cord-005453-4057qib7 9281 1 ( ( -LRB- cord-005453-4057qib7 9281 2 range range NN cord-005453-4057qib7 9281 3 : : : cord-005453-4057qib7 9281 4 21 21 CD cord-005453-4057qib7 9281 5 - - SYM cord-005453-4057qib7 9281 6 79 79 CD cord-005453-4057qib7 9281 7 ) ) -RRB- cord-005453-4057qib7 9281 8 , , . cord-005453-4057qib7 9282 1 the the DT cord-005453-4057qib7 9282 2 sex sex NN cord-005453-4057qib7 9282 3 ratio ratio NN cord-005453-4057qib7 9282 4 M M NNP cord-005453-4057qib7 9282 5 / / SYM cord-005453-4057qib7 9282 6 F f NN cord-005453-4057qib7 9282 7 : : : cord-005453-4057qib7 9282 8 0,5 0,5 NFP cord-005453-4057qib7 9282 9 . . . cord-005453-4057qib7 9283 1 The the DT cord-005453-4057qib7 9283 2 underlying underlie VBG cord-005453-4057qib7 9283 3 diseases disease NNS cord-005453-4057qib7 9283 4 were be VBD cord-005453-4057qib7 9283 5 acute acute JJ cord-005453-4057qib7 9283 6 leukemia leukemia NN cord-005453-4057qib7 9283 7 : : : cord-005453-4057qib7 9283 8 49 49 CD cord-005453-4057qib7 9283 9 ( ( -LRB- cord-005453-4057qib7 9283 10 57 57 CD cord-005453-4057qib7 9283 11 % % NN cord-005453-4057qib7 9283 12 ) ) -RRB- cord-005453-4057qib7 9283 13 , , , cord-005453-4057qib7 9283 14 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 9283 15 syndrome syndrome NN cord-005453-4057qib7 9283 16 : : : cord-005453-4057qib7 9283 17 5 5 CD cord-005453-4057qib7 9283 18 ( ( -LRB- cord-005453-4057qib7 9283 19 6 6 CD cord-005453-4057qib7 9283 20 % % NN cord-005453-4057qib7 9283 21 ) ) -RRB- cord-005453-4057qib7 9283 22 , , , cord-005453-4057qib7 9283 23 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 9283 24 diseases disease NNS cord-005453-4057qib7 9283 25 : : : cord-005453-4057qib7 9283 26 17 17 CD cord-005453-4057qib7 9283 27 ( ( -LRB- cord-005453-4057qib7 9283 28 19.5 19.5 CD cord-005453-4057qib7 9283 29 % % NN cord-005453-4057qib7 9283 30 ) ) -RRB- cord-005453-4057qib7 9283 31 , , , cord-005453-4057qib7 9283 32 myeloproliferative myeloproliferative JJ cord-005453-4057qib7 9283 33 neoplasms neoplasm NNS cord-005453-4057qib7 9283 34 : : : cord-005453-4057qib7 9283 35 11 11 CD cord-005453-4057qib7 9283 36 ( ( -LRB- cord-005453-4057qib7 9283 37 13 13 CD cord-005453-4057qib7 9283 38 % % NN cord-005453-4057qib7 9283 39 ) ) -RRB- cord-005453-4057qib7 9283 40 and and CC cord-005453-4057qib7 9283 41 non non JJ cord-005453-4057qib7 9283 42 - - JJ cord-005453-4057qib7 9283 43 malignant malignant JJ cord-005453-4057qib7 9283 44 diseases disease NNS cord-005453-4057qib7 9283 45 : : : cord-005453-4057qib7 9283 46 4 4 CD cord-005453-4057qib7 9283 47 ( ( -LRB- cord-005453-4057qib7 9283 48 4.5 4.5 CD cord-005453-4057qib7 9283 49 % % NN cord-005453-4057qib7 9283 50 ) ) -RRB- cord-005453-4057qib7 9283 51 . . . cord-005453-4057qib7 9284 1 The the DT cord-005453-4057qib7 9284 2 HCT HCT NNP cord-005453-4057qib7 9284 3 was be VBD cord-005453-4057qib7 9284 4 performed perform VBN cord-005453-4057qib7 9284 5 from from IN cord-005453-4057qib7 9284 6 an an DT cord-005453-4057qib7 9284 7 HLA HLA NNP cord-005453-4057qib7 9284 8 - - HYPH cord-005453-4057qib7 9284 9 identical identical JJ cord-005453-4057qib7 9284 10 donor donor NN cord-005453-4057qib7 9284 11 in in IN cord-005453-4057qib7 9284 12 52 52 CD cord-005453-4057qib7 9284 13 , , , cord-005453-4057qib7 9284 14 an an DT cord-005453-4057qib7 9284 15 unrelated unrelated JJ cord-005453-4057qib7 9284 16 donor donor NN cord-005453-4057qib7 9284 17 in in IN cord-005453-4057qib7 9284 18 30 30 CD cord-005453-4057qib7 9284 19 , , , cord-005453-4057qib7 9284 20 and and CC cord-005453-4057qib7 9284 21 a a DT cord-005453-4057qib7 9284 22 cord cord NN cord-005453-4057qib7 9284 23 - - HYPH cord-005453-4057qib7 9284 24 blood blood NN cord-005453-4057qib7 9284 25 in in IN cord-005453-4057qib7 9284 26 4 4 CD cord-005453-4057qib7 9284 27 . . . cord-005453-4057qib7 9285 1 Conditioning conditioning NN cord-005453-4057qib7 9285 2 regimen regimen NN cord-005453-4057qib7 9285 3 were be VBD cord-005453-4057qib7 9285 4 MA MA NNP cord-005453-4057qib7 9285 5 in in IN cord-005453-4057qib7 9285 6 48 48 CD cord-005453-4057qib7 9285 7 ( ( -LRB- cord-005453-4057qib7 9285 8 56 56 CD cord-005453-4057qib7 9285 9 % % NN cord-005453-4057qib7 9285 10 ) ) -RRB- cord-005453-4057qib7 9285 11 , , , cord-005453-4057qib7 9285 12 RIC RIC NNP cord-005453-4057qib7 9285 13 in in IN cord-005453-4057qib7 9285 14 20 20 CD cord-005453-4057qib7 9285 15 ( ( -LRB- cord-005453-4057qib7 9285 16 23 23 CD cord-005453-4057qib7 9285 17 % % NN cord-005453-4057qib7 9285 18 ) ) -RRB- cord-005453-4057qib7 9285 19 and and CC cord-005453-4057qib7 9285 20 non non JJ cord-005453-4057qib7 9285 21 - - JJ cord-005453-4057qib7 9285 22 MA MA NNP cord-005453-4057qib7 9285 23 in in IN cord-005453-4057qib7 9285 24 18 18 CD cord-005453-4057qib7 9285 25 ( ( -LRB- cord-005453-4057qib7 9285 26 21 21 CD cord-005453-4057qib7 9285 27 % % NN cord-005453-4057qib7 9285 28 ) ) -RRB- cord-005453-4057qib7 9285 29 patients patient NNS cord-005453-4057qib7 9286 1 No no DT cord-005453-4057qib7 9286 2 patient patient NN cord-005453-4057qib7 9286 3 had have VBD cord-005453-4057qib7 9286 4 experienced experience VBN cord-005453-4057qib7 9286 5 measles measle NNS cord-005453-4057qib7 9286 6 or or CC cord-005453-4057qib7 9286 7 had have VBD cord-005453-4057qib7 9286 8 received receive VBN cord-005453-4057qib7 9286 9 measles measle NNS cord-005453-4057qib7 9286 10 vaccination vaccination NN cord-005453-4057qib7 9286 11 since since IN cord-005453-4057qib7 9286 12 transplant transplant NN cord-005453-4057qib7 9286 13 . . . cord-005453-4057qib7 9287 1 Fifty fifty CD cord-005453-4057qib7 9287 2 - - HYPH cord-005453-4057qib7 9287 3 seven seven CD cord-005453-4057qib7 9287 4 of of IN cord-005453-4057qib7 9287 5 the the DT cord-005453-4057qib7 9287 6 86 86 CD cord-005453-4057qib7 9287 7 ( ( -LRB- cord-005453-4057qib7 9287 8 66 66 CD cord-005453-4057qib7 9287 9 % % NN cord-005453-4057qib7 9287 10 ) ) -RRB- cord-005453-4057qib7 9287 11 patients patient NNS cord-005453-4057qib7 9287 12 were be VBD cord-005453-4057qib7 9287 13 seropositive seropositive JJ cord-005453-4057qib7 9287 14 for for IN cord-005453-4057qib7 9287 15 measles measle NNS cord-005453-4057qib7 9287 16 . . . cord-005453-4057qib7 9288 1 Measles Measles NNP cord-005453-4057qib7 9288 2 seropositivity seropositivity NN cord-005453-4057qib7 9288 3 was be VBD cord-005453-4057qib7 9288 4 not not RB cord-005453-4057qib7 9288 5 associated associate VBN cord-005453-4057qib7 9288 6 with with IN cord-005453-4057qib7 9288 7 conditioning conditioning NN cord-005453-4057qib7 9288 8 regimen regimen NN cord-005453-4057qib7 9288 9 , , , cord-005453-4057qib7 9288 10 patient patient JJ cord-005453-4057qib7 9288 11 age age NN cord-005453-4057qib7 9288 12 at at IN cord-005453-4057qib7 9288 13 transplant transplant NN cord-005453-4057qib7 9288 14 , , , cord-005453-4057qib7 9288 15 patient patient JJ cord-005453-4057qib7 9288 16 age age NN cord-005453-4057qib7 9288 17 at at IN cord-005453-4057qib7 9288 18 time time NN cord-005453-4057qib7 9288 19 of of IN cord-005453-4057qib7 9288 20 assessment assessment NN cord-005453-4057qib7 9288 21 , , , cord-005453-4057qib7 9289 1 donor donor NN cord-005453-4057qib7 9289 2 age age NN cord-005453-4057qib7 9289 3 at at IN cord-005453-4057qib7 9289 4 transplant transplant NN cord-005453-4057qib7 9289 5 , , , cord-005453-4057qib7 9289 6 lymphocyte lymphocyte NN cord-005453-4057qib7 9289 7 count count NN cord-005453-4057qib7 9289 8 or or CC cord-005453-4057qib7 9289 9 gammaglobulin gammaglobulin NN cord-005453-4057qib7 9289 10 levels level NNS cord-005453-4057qib7 9289 11 , , , cord-005453-4057qib7 9289 12 or or CC cord-005453-4057qib7 9289 13 type type NN cord-005453-4057qib7 9289 14 of of IN cord-005453-4057qib7 9289 15 transplant transplant NN cord-005453-4057qib7 9289 16 ( ( -LRB- cord-005453-4057qib7 9289 17 HLAid HLAid NNP cord-005453-4057qib7 9289 18 . . . cord-005453-4057qib7 9290 1 vs vs IN cord-005453-4057qib7 9290 2 others other NNS cord-005453-4057qib7 9290 3 ) ) -RRB- cord-005453-4057qib7 9290 4 measles measle NNS cord-005453-4057qib7 9290 5 vaccination vaccination NN cord-005453-4057qib7 9290 6 before before IN cord-005453-4057qib7 9290 7 transplant transplant NN cord-005453-4057qib7 9290 8 or or CC cord-005453-4057qib7 9290 9 previous previous JJ cord-005453-4057qib7 9290 10 measles measle NNS cord-005453-4057qib7 9290 11 before before IN cord-005453-4057qib7 9290 12 transplant transplant NN cord-005453-4057qib7 9290 13 . . . cord-005453-4057qib7 9291 1 The the DT cord-005453-4057qib7 9291 2 only only JJ cord-005453-4057qib7 9291 3 parameters parameter NNS cord-005453-4057qib7 9291 4 significantly significantly RB cord-005453-4057qib7 9291 5 associated associate VBN cord-005453-4057qib7 9291 6 to to IN cord-005453-4057qib7 9291 7 seropositivity seropositivity NN cord-005453-4057qib7 9291 8 were be VBD cord-005453-4057qib7 9291 9 absence absence NN cord-005453-4057qib7 9291 10 of of IN cord-005453-4057qib7 9291 11 previous previous JJ cord-005453-4057qib7 9291 12 GvHD gvhd NN cord-005453-4057qib7 9291 13 ( ( -LRB- cord-005453-4057qib7 9291 14 any any DT cord-005453-4057qib7 9291 15 type type NN cord-005453-4057qib7 9291 16 or or CC cord-005453-4057qib7 9291 17 severity severity NN cord-005453-4057qib7 9291 18 , , , cord-005453-4057qib7 9291 19 p=0,033 p=0,033 NNP cord-005453-4057qib7 9292 1 OR or CC cord-005453-4057qib7 9292 2 0,31 0,31 CD cord-005453-4057qib7 9293 1 [ [ -LRB- cord-005453-4057qib7 9293 2 0,10 0,10 NN cord-005453-4057qib7 9293 3 - - HYPH cord-005453-4057qib7 9293 4 0,94 0,94 CD cord-005453-4057qib7 9293 5 ] ] -RRB- cord-005453-4057qib7 9293 6 ) ) -RRB- cord-005453-4057qib7 9293 7 , , , cord-005453-4057qib7 9293 8 and and CC cord-005453-4057qib7 9293 9 absence absence NN cord-005453-4057qib7 9293 10 of of IN cord-005453-4057qib7 9293 11 previous previous JJ cord-005453-4057qib7 9293 12 extensive extensive JJ cord-005453-4057qib7 9293 13 chronic chronic JJ cord-005453-4057qib7 9293 14 GvHD gvhd NN cord-005453-4057qib7 9293 15 ( ( -LRB- cord-005453-4057qib7 9293 16 OR or CC cord-005453-4057qib7 9293 17 0 0 CD cord-005453-4057qib7 9293 18 , , , cord-005453-4057qib7 9293 19 28 28 CD cord-005453-4057qib7 9293 20 [ [ -LRB- cord-005453-4057qib7 9293 21 0 0 CD cord-005453-4057qib7 9293 22 , , , cord-005453-4057qib7 9293 23 87 87 CD cord-005453-4057qib7 9293 24 ] ] -RRB- cord-005453-4057qib7 9293 25 p0,027 p0,027 CD cord-005453-4057qib7 9293 26 ) ) -RRB- cord-005453-4057qib7 9293 27 . . . cord-005453-4057qib7 9294 1 Conclusions conclusion NNS cord-005453-4057qib7 9294 2 : : : cord-005453-4057qib7 9295 1 Sixty sixty CD cord-005453-4057qib7 9295 2 - - HYPH cord-005453-4057qib7 9295 3 seven seven CD cord-005453-4057qib7 9295 4 percent percent NN cord-005453-4057qib7 9295 5 of of IN cord-005453-4057qib7 9295 6 allogeneic allogeneic NN cord-005453-4057qib7 9295 7 HCT hct NN cord-005453-4057qib7 9295 8 are be VBP cord-005453-4057qib7 9295 9 seropositive seropositive JJ cord-005453-4057qib7 9295 10 for for IN cord-005453-4057qib7 9295 11 measles measle NNS cord-005453-4057qib7 9295 12 at at IN cord-005453-4057qib7 9295 13 a a DT cord-005453-4057qib7 9295 14 median median NN cord-005453-4057qib7 9295 15 of of IN cord-005453-4057qib7 9295 16 7 7 CD cord-005453-4057qib7 9295 17 years year NNS cord-005453-4057qib7 9295 18 after after IN cord-005453-4057qib7 9295 19 HCT hct NN cord-005453-4057qib7 9295 20 before before IN cord-005453-4057qib7 9295 21 vaccination vaccination NN cord-005453-4057qib7 9295 22 . . . cord-005453-4057qib7 9296 1 The the DT cord-005453-4057qib7 9296 2 only only JJ cord-005453-4057qib7 9296 3 risk risk NN cord-005453-4057qib7 9296 4 factor factor NN cord-005453-4057qib7 9296 5 strongly strongly RB cord-005453-4057qib7 9296 6 associated associate VBD cord-005453-4057qib7 9296 7 with with IN cord-005453-4057qib7 9296 8 seronegativity seronegativity NN cord-005453-4057qib7 9296 9 is be VBZ cord-005453-4057qib7 9296 10 extensive extensive JJ cord-005453-4057qib7 9296 11 chronic chronic JJ cord-005453-4057qib7 9296 12 GvHD gvhd NN cord-005453-4057qib7 9296 13 . . . cord-005453-4057qib7 9297 1 In in IN cord-005453-4057qib7 9297 2 patients patient NNS cord-005453-4057qib7 9297 3 Background background NN cord-005453-4057qib7 9297 4 : : : cord-005453-4057qib7 9297 5 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 9297 6 ( ( -LRB- cord-005453-4057qib7 9297 7 CMV CMV NNP cord-005453-4057qib7 9297 8 ) ) -RRB- cord-005453-4057qib7 9297 9 reactivation reactivation NN cord-005453-4057qib7 9297 10 is be VBZ cord-005453-4057qib7 9297 11 a a DT cord-005453-4057qib7 9297 12 frequent frequent JJ cord-005453-4057qib7 9297 13 complication complication NN cord-005453-4057qib7 9297 14 after after IN cord-005453-4057qib7 9297 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 9297 16 stem stem NN cord-005453-4057qib7 9297 17 cell cell NN cord-005453-4057qib7 9297 18 transplantation transplantation NN cord-005453-4057qib7 9297 19 ( ( -LRB- cord-005453-4057qib7 9297 20 HSCT HSCT NNP cord-005453-4057qib7 9297 21 ) ) -RRB- cord-005453-4057qib7 9297 22 . . . cord-005453-4057qib7 9298 1 Extracellular Extracellular NNP cord-005453-4057qib7 9298 2 Vesicles Vesicles NNP cord-005453-4057qib7 9298 3 ( ( -LRB- cord-005453-4057qib7 9298 4 EVs ev NNS cord-005453-4057qib7 9298 5 ) ) -RRB- cord-005453-4057qib7 9298 6 have have VBP cord-005453-4057qib7 9298 7 emerged emerge VBN cord-005453-4057qib7 9298 8 as as IN cord-005453-4057qib7 9298 9 a a DT cord-005453-4057qib7 9298 10 promising promising JJ cord-005453-4057qib7 9298 11 new new JJ cord-005453-4057qib7 9298 12 category category NN cord-005453-4057qib7 9298 13 of of IN cord-005453-4057qib7 9298 14 biological biological JJ cord-005453-4057qib7 9298 15 biomarkers biomarker NNS cord-005453-4057qib7 9298 16 in in IN cord-005453-4057qib7 9298 17 different different JJ cord-005453-4057qib7 9298 18 scenarios scenario NNS cord-005453-4057qib7 9298 19 , , , cord-005453-4057qib7 9298 20 including include VBG cord-005453-4057qib7 9298 21 inflammation inflammation NN cord-005453-4057qib7 9298 22 , , , cord-005453-4057qib7 9298 23 tissue tissue NN cord-005453-4057qib7 9298 24 damage damage NN cord-005453-4057qib7 9298 25 , , , cord-005453-4057qib7 9298 26 cancer cancer NN cord-005453-4057qib7 9298 27 and and CC cord-005453-4057qib7 9298 28 viral viral JJ cord-005453-4057qib7 9298 29 infections infection NNS cord-005453-4057qib7 9298 30 . . . cord-005453-4057qib7 9299 1 We -PRON- PRP cord-005453-4057qib7 9299 2 recently recently RB cord-005453-4057qib7 9299 3 reported report VBD cord-005453-4057qib7 9299 4 on on IN cord-005453-4057qib7 9299 5 the the DT cord-005453-4057qib7 9299 6 potential potential JJ cord-005453-4057qib7 9299 7 use use NN cord-005453-4057qib7 9299 8 of of IN cord-005453-4057qib7 9299 9 serum serum NN cord-005453-4057qib7 9299 10 EVs ev NNS cord-005453-4057qib7 9299 11 as as IN cord-005453-4057qib7 9299 12 biomarkers biomarker NNS cord-005453-4057qib7 9299 13 of of IN cord-005453-4057qib7 9299 14 aGVHD aGVHD NNP cord-005453-4057qib7 9300 1 ( ( -LRB- cord-005453-4057qib7 9300 2 Lia Lia NNP cord-005453-4057qib7 9300 3 G. G. NNP cord-005453-4057qib7 9300 4 et et NNP cord-005453-4057qib7 9300 5 al al NNP cord-005453-4057qib7 9300 6 . . . cord-005453-4057qib7 9301 1 Leukemia leukemia NN cord-005453-4057qib7 9301 2 ( ( -LRB- cord-005453-4057qib7 9301 3 2018 2018 CD cord-005453-4057qib7 9301 4 ) ) -RRB- cord-005453-4057qib7 9301 5 32 32 CD cord-005453-4057qib7 9301 6 , , , cord-005453-4057qib7 9301 7 765 765 CD cord-005453-4057qib7 9301 8 ) ) -RRB- cord-005453-4057qib7 9301 9 . . . cord-005453-4057qib7 9302 1 Here here RB cord-005453-4057qib7 9302 2 , , , cord-005453-4057qib7 9302 3 we -PRON- PRP cord-005453-4057qib7 9302 4 investigated investigate VBD cord-005453-4057qib7 9302 5 the the DT cord-005453-4057qib7 9302 6 potential potential JJ cord-005453-4057qib7 9302 7 correlation correlation NN cord-005453-4057qib7 9302 8 of of IN cord-005453-4057qib7 9302 9 CMV CMV NNP cord-005453-4057qib7 9302 10 reactivation reactivation NN cord-005453-4057qib7 9302 11 with with IN cord-005453-4057qib7 9302 12 plasma plasma NN cord-005453-4057qib7 9302 13 EVs ev NNS cord-005453-4057qib7 9302 14 in in IN cord-005453-4057qib7 9302 15 post post JJ cord-005453-4057qib7 9302 16 - - JJ cord-005453-4057qib7 9302 17 transplant transplant NN cord-005453-4057qib7 9302 18 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 9302 19 ( ( -LRB- cord-005453-4057qib7 9302 20 PTCY PTCY NNP cord-005453-4057qib7 9302 21 ) ) -RRB- cord-005453-4057qib7 9302 22 haploidentical haploidentical JJ cord-005453-4057qib7 9302 23 - - HYPH cord-005453-4057qib7 9302 24 HSCT HSCT NNP cord-005453-4057qib7 9302 25 ( ( -LRB- cord-005453-4057qib7 9302 26 Haplo Haplo NNP cord-005453-4057qib7 9302 27 - - HYPH cord-005453-4057qib7 9302 28 HSCT HSCT NNP cord-005453-4057qib7 9302 29 ) ) -RRB- cord-005453-4057qib7 9302 30 . . . cord-005453-4057qib7 9303 1 Methods method NNS cord-005453-4057qib7 9303 2 : : : cord-005453-4057qib7 9303 3 Plasma plasma NN cord-005453-4057qib7 9303 4 samples sample NNS cord-005453-4057qib7 9303 5 were be VBD cord-005453-4057qib7 9303 6 collected collect VBN cord-005453-4057qib7 9303 7 after after IN cord-005453-4057qib7 9303 8 mononuclear mononuclear JJ cord-005453-4057qib7 9303 9 cell cell NN cord-005453-4057qib7 9303 10 separation separation NN cord-005453-4057qib7 9303 11 at at IN cord-005453-4057qib7 9303 12 given give VBN cord-005453-4057qib7 9303 13 time time NN cord-005453-4057qib7 9303 14 - - HYPH cord-005453-4057qib7 9303 15 points point NNS cord-005453-4057qib7 9303 16 ( ( -LRB- cord-005453-4057qib7 9303 17 pre pre JJ cord-005453-4057qib7 9303 18 - - NN cord-005453-4057qib7 9303 19 transplant transplant NN cord-005453-4057qib7 9303 20 , , , cord-005453-4057qib7 9303 21 on on IN cord-005453-4057qib7 9303 22 day day NN cord-005453-4057qib7 9303 23 0 0 CD cord-005453-4057qib7 9303 24 , , , cord-005453-4057qib7 9303 25 3 3 CD cord-005453-4057qib7 9303 26 , , , cord-005453-4057qib7 9303 27 7 7 CD cord-005453-4057qib7 9303 28 , , , cord-005453-4057qib7 9303 29 14 14 CD cord-005453-4057qib7 9303 30 , , , cord-005453-4057qib7 9303 31 21 21 CD cord-005453-4057qib7 9303 32 , , , cord-005453-4057qib7 9303 33 28 28 CD cord-005453-4057qib7 9303 34 , , , cord-005453-4057qib7 9303 35 35 35 CD cord-005453-4057qib7 9303 36 , , , cord-005453-4057qib7 9303 37 45 45 CD cord-005453-4057qib7 9303 38 , , , cord-005453-4057qib7 9303 39 60 60 CD cord-005453-4057qib7 9303 40 , , , cord-005453-4057qib7 9303 41 75 75 CD cord-005453-4057qib7 9303 42 and and CC cord-005453-4057qib7 9303 43 90 90 CD cord-005453-4057qib7 9303 44 after after IN cord-005453-4057qib7 9303 45 Haplo Haplo NNP cord-005453-4057qib7 9303 46 - - HYPH cord-005453-4057qib7 9303 47 HSCT HSCT NNP cord-005453-4057qib7 9303 48 ) ) -RRB- cord-005453-4057qib7 9303 49 and and CC cord-005453-4057qib7 9303 50 EVs ev NNS cord-005453-4057qib7 9303 51 were be VBD cord-005453-4057qib7 9303 52 extracted extract VBN cord-005453-4057qib7 9303 53 by by IN cord-005453-4057qib7 9303 54 a a DT cord-005453-4057qib7 9303 55 protamine protamine NN cord-005453-4057qib7 9303 56 - - HYPH cord-005453-4057qib7 9303 57 based base VBN cord-005453-4057qib7 9303 58 precipitation precipitation NN cord-005453-4057qib7 9303 59 method method NN cord-005453-4057qib7 9303 60 and and CC cord-005453-4057qib7 9303 61 their -PRON- PRP$ cord-005453-4057qib7 9303 62 concentration concentration NN cord-005453-4057qib7 9303 63 and and CC cord-005453-4057qib7 9303 64 dimension dimension NN cord-005453-4057qib7 9303 65 were be VBD cord-005453-4057qib7 9303 66 characterized characterize VBN cord-005453-4057qib7 9303 67 by by IN cord-005453-4057qib7 9303 68 Nano Nano NNP cord-005453-4057qib7 9303 69 - - HYPH cord-005453-4057qib7 9303 70 tracking track VBG cord-005453-4057qib7 9303 71 Particle Particle NNP cord-005453-4057qib7 9303 72 Analysis Analysis NNP cord-005453-4057qib7 9303 73 ( ( -LRB- cord-005453-4057qib7 9303 74 Nanosight Nanosight NNP cord-005453-4057qib7 9303 75 ) ) -RRB- cord-005453-4057qib7 9303 76 . . . cord-005453-4057qib7 9304 1 After after IN cord-005453-4057qib7 9304 2 extraction extraction NN cord-005453-4057qib7 9304 3 , , , cord-005453-4057qib7 9304 4 EVs ev NNS cord-005453-4057qib7 9304 5 were be VBD cord-005453-4057qib7 9304 6 analyzed analyze VBN cord-005453-4057qib7 9304 7 by by IN cord-005453-4057qib7 9304 8 flowcytometry flowcytometry NN cord-005453-4057qib7 9304 9 ( ( -LRB- cord-005453-4057qib7 9304 10 Guava Guava NNP cord-005453-4057qib7 9304 11 EasyCyte EasyCyte NNP cord-005453-4057qib7 9304 12 Flow Flow NNP cord-005453-4057qib7 9304 13 Cytometer Cytometer NNP cord-005453-4057qib7 9304 14 ) ) -RRB- cord-005453-4057qib7 9304 15 with with IN cord-005453-4057qib7 9304 16 a a DT cord-005453-4057qib7 9304 17 panel panel NN cord-005453-4057qib7 9304 18 of of IN cord-005453-4057qib7 9304 19 14 14 CD cord-005453-4057qib7 9304 20 antibodies antibody NNS cord-005453-4057qib7 9304 21 ( ( -LRB- cord-005453-4057qib7 9304 22 CD44 CD44 NNP cord-005453-4057qib7 9304 23 , , , cord-005453-4057qib7 9304 24 CD138 CD138 NNP cord-005453-4057qib7 9304 25 , , , cord-005453-4057qib7 9304 26 CD146 CD146 NNP cord-005453-4057qib7 9304 27 , , , cord-005453-4057qib7 9304 28 KRT18 KRT18 NNP cord-005453-4057qib7 9304 29 , , , cord-005453-4057qib7 9304 30 CD120a CD120a NNP cord-005453-4057qib7 9304 31 , , , cord-005453-4057qib7 9304 32 CD8 CD8 NNP cord-005453-4057qib7 9304 33 , , , cord-005453-4057qib7 9304 34 CD30 CD30 NNP cord-005453-4057qib7 9304 35 , , , cord-005453-4057qib7 9304 36 CD106 cd106 CD cord-005453-4057qib7 9304 37 , , , cord-005453-4057qib7 9304 38 CD25 CD25 NNP cord-005453-4057qib7 9304 39 , , , cord-005453-4057qib7 9304 40 CD26 CD26 NNP cord-005453-4057qib7 9304 41 , , , cord-005453-4057qib7 9304 42 CD31 CD31 NNP cord-005453-4057qib7 9304 43 , , , cord-005453-4057qib7 9304 44 CD144 CD144 NNP cord-005453-4057qib7 9304 45 , , , cord-005453-4057qib7 9304 46 CD86 CD86 NNP cord-005453-4057qib7 9304 47 , , , cord-005453-4057qib7 9304 48 and and CC cord-005453-4057qib7 9304 49 CD140a CD140a NNP cord-005453-4057qib7 9304 50 ) ) -RRB- cord-005453-4057qib7 9304 51 . . . cord-005453-4057qib7 9305 1 Results result NNS cord-005453-4057qib7 9305 2 : : : cord-005453-4057qib7 9306 1 Thirty thirty CD cord-005453-4057qib7 9306 2 - - HYPH cord-005453-4057qib7 9306 3 two two CD cord-005453-4057qib7 9306 4 patients patient NNS cord-005453-4057qib7 9306 5 with with IN cord-005453-4057qib7 9306 6 hematological hematological JJ cord-005453-4057qib7 9306 7 malignancies malignancy NNS cord-005453-4057qib7 9306 8 underwent undergo VBD cord-005453-4057qib7 9306 9 haplo haplo NN cord-005453-4057qib7 9306 10 - - HYPH cord-005453-4057qib7 9306 11 HSCT HSCT NNP cord-005453-4057qib7 9306 12 between between IN cord-005453-4057qib7 9306 13 2011 2011 CD cord-005453-4057qib7 9306 14 and and CC cord-005453-4057qib7 9306 15 2015 2015 CD cord-005453-4057qib7 9306 16 . . . cord-005453-4057qib7 9307 1 CMV CMV NNP cord-005453-4057qib7 9307 2 reactivation reactivation NN cord-005453-4057qib7 9307 3 was be VBD cord-005453-4057qib7 9307 4 observed observe VBN cord-005453-4057qib7 9307 5 in in IN cord-005453-4057qib7 9307 6 20/32 20/32 CD cord-005453-4057qib7 9307 7 ( ( -LRB- cord-005453-4057qib7 9307 8 62,5 62,5 CD cord-005453-4057qib7 9307 9 % % NN cord-005453-4057qib7 9307 10 ) ) -RRB- cord-005453-4057qib7 9307 11 and and CC cord-005453-4057qib7 9307 12 occurred occur VBD cord-005453-4057qib7 9307 13 at at IN cord-005453-4057qib7 9307 14 a a DT cord-005453-4057qib7 9307 15 median median NN cord-005453-4057qib7 9307 16 of of IN cord-005453-4057qib7 9307 17 50 50 CD cord-005453-4057qib7 9307 18 ( ( -LRB- cord-005453-4057qib7 9307 19 range range NN cord-005453-4057qib7 9307 20 : : : cord-005453-4057qib7 9307 21 10 10 CD cord-005453-4057qib7 9307 22 - - SYM cord-005453-4057qib7 9307 23 275 275 CD cord-005453-4057qib7 9307 24 ) ) -RRB- cord-005453-4057qib7 9307 25 days day NNS cord-005453-4057qib7 9307 26 after after IN cord-005453-4057qib7 9307 27 transplant transplant NN cord-005453-4057qib7 9307 28 . . . cord-005453-4057qib7 9308 1 Preliminary preliminary JJ cord-005453-4057qib7 9308 2 analysis analysis NN cord-005453-4057qib7 9308 3 ( ( -LRB- cord-005453-4057qib7 9308 4 17/32 17/32 CD cord-005453-4057qib7 9308 5 patients patient NNS cord-005453-4057qib7 9308 6 ) ) -RRB- cord-005453-4057qib7 9308 7 showed show VBD cord-005453-4057qib7 9308 8 that that IN cord-005453-4057qib7 9308 9 CD140a CD140a NNP cord-005453-4057qib7 9308 10 fluorescence fluorescence NN cord-005453-4057qib7 9308 11 ( ( -LRB- cord-005453-4057qib7 9308 12 platelet platelet NN cord-005453-4057qib7 9308 13 - - HYPH cord-005453-4057qib7 9308 14 derived derive VBN cord-005453-4057qib7 9308 15 growth growth NN cord-005453-4057qib7 9308 16 factor factor NN cord-005453-4057qib7 9308 17 receptor receptor NN cord-005453-4057qib7 9308 18 - - HYPH cord-005453-4057qib7 9308 19 α α NN cord-005453-4057qib7 9308 20 or or CC cord-005453-4057qib7 9308 21 PDGFR PDGFR NNP cord-005453-4057qib7 9308 22 - - HYPH cord-005453-4057qib7 9308 23 α α NNP cord-005453-4057qib7 9308 24 ) ) -RRB- cord-005453-4057qib7 9308 25 , , , cord-005453-4057qib7 9308 26 CD30 CD30 NNP cord-005453-4057qib7 9308 27 fluorescence fluorescence NN cord-005453-4057qib7 9308 28 ( ( -LRB- cord-005453-4057qib7 9308 29 Ki-1 Ki-1 NNP cord-005453-4057qib7 9308 30 antigen antigen NNP cord-005453-4057qib7 9308 31 ) ) -RRB- cord-005453-4057qib7 9308 32 and and CC cord-005453-4057qib7 9308 33 CD144 cd144 NN cord-005453-4057qib7 9308 34 fluorescence fluorescence NN cord-005453-4057qib7 9308 35 ( ( -LRB- cord-005453-4057qib7 9308 36 VE VE NNP cord-005453-4057qib7 9308 37 - - HYPH cord-005453-4057qib7 9308 38 Cadherin Cadherin NNP cord-005453-4057qib7 9308 39 ) ) -RRB- cord-005453-4057qib7 9308 40 were be VBD cord-005453-4057qib7 9308 41 associated associate VBN cord-005453-4057qib7 9308 42 with with IN cord-005453-4057qib7 9308 43 an an DT cord-005453-4057qib7 9308 44 increased increase VBN cord-005453-4057qib7 9308 45 risk risk NN cord-005453-4057qib7 9308 46 of of IN cord-005453-4057qib7 9308 47 CMV CMV NNP cord-005453-4057qib7 9308 48 reactivation reactivation NN cord-005453-4057qib7 9308 49 ( ( -LRB- cord-005453-4057qib7 9308 50 OR or CC cord-005453-4057qib7 9308 51 2.67 2.67 CD cord-005453-4057qib7 9308 52 p=0.045 p=0.045 NNS cord-005453-4057qib7 9308 53 ; ; : cord-005453-4057qib7 9308 54 OR or CC cord-005453-4057qib7 9308 55 3.11 3.11 CD cord-005453-4057qib7 9308 56 p=0.011 p=0.011 XX cord-005453-4057qib7 9308 57 ; ; : cord-005453-4057qib7 9308 58 OR or CC cord-005453-4057qib7 9308 59 2.37 2.37 CD cord-005453-4057qib7 9308 60 p=0.08 p=0.08 NNP cord-005453-4057qib7 9308 61 ) ) -RRB- cord-005453-4057qib7 9308 62 , , , cord-005453-4057qib7 9308 63 whereas whereas IN cord-005453-4057qib7 9308 64 CD31 CD31 NNP cord-005453-4057qib7 9308 65 ( ( -LRB- cord-005453-4057qib7 9308 66 platelet platelet JJ cord-005453-4057qib7 9308 67 endothelial endothelial JJ cord-005453-4057qib7 9308 68 cell cell NN cord-005453-4057qib7 9308 69 adhesion adhesion NN cord-005453-4057qib7 9308 70 molecule molecule NN cord-005453-4057qib7 9308 71 , , , cord-005453-4057qib7 9308 72 PECAM-1 PECAM-1 NNP cord-005453-4057qib7 9308 73 ) ) -RRB- cord-005453-4057qib7 9309 1 concentration concentration NN cord-005453-4057qib7 9309 2 level level NN cord-005453-4057qib7 9309 3 was be VBD cord-005453-4057qib7 9309 4 associated associate VBN cord-005453-4057qib7 9309 5 with with IN cord-005453-4057qib7 9309 6 a a DT cord-005453-4057qib7 9309 7 decreased decreased JJ cord-005453-4057qib7 9309 8 risk risk NN cord-005453-4057qib7 9309 9 of of IN cord-005453-4057qib7 9309 10 CMV CMV NNP cord-005453-4057qib7 9309 11 reactivation reactivation NN cord-005453-4057qib7 9309 12 ( ( -LRB- cord-005453-4057qib7 9309 13 OR or CC cord-005453-4057qib7 9309 14 0.26 0.26 CD cord-005453-4057qib7 9309 15 , , , cord-005453-4057qib7 9309 16 p=0.032 p=0.032 NNPS cord-005453-4057qib7 9309 17 ) ) -RRB- cord-005453-4057qib7 9309 18 . . . cord-005453-4057qib7 9310 1 All all PDT cord-005453-4057qib7 9310 2 these these DT cord-005453-4057qib7 9310 3 biomarkers biomarker NNS cord-005453-4057qib7 9310 4 showed show VBD cord-005453-4057qib7 9310 5 a a DT cord-005453-4057qib7 9310 6 signal signal NN cord-005453-4057qib7 9310 7 change change NN cord-005453-4057qib7 9310 8 before before IN cord-005453-4057qib7 9310 9 CMV CMV NNP cord-005453-4057qib7 9310 10 reactivation reactivation NN cord-005453-4057qib7 9310 11 ( ( -LRB- cord-005453-4057qib7 9310 12 an an DT cord-005453-4057qib7 9310 13 increase increase NN cord-005453-4057qib7 9310 14 with with IN cord-005453-4057qib7 9310 15 CD140a CD140a NNP cord-005453-4057qib7 9310 16 , , , cord-005453-4057qib7 9310 17 CD30 CD30 NNP cord-005453-4057qib7 9310 18 and and CC cord-005453-4057qib7 9310 19 CD144 CD144 NNP cord-005453-4057qib7 9310 20 , , , cord-005453-4057qib7 9310 21 a a DT cord-005453-4057qib7 9310 22 reduction reduction NN cord-005453-4057qib7 9310 23 with with IN cord-005453-4057qib7 9310 24 CD31 CD31 NNP cord-005453-4057qib7 9310 25 ) ) -RRB- cord-005453-4057qib7 9310 26 . . . cord-005453-4057qib7 9311 1 ( ( -LRB- cord-005453-4057qib7 9311 2 Figure figure NN cord-005453-4057qib7 9311 3 1 1 CD cord-005453-4057qib7 9311 4 ) ) -RRB- cord-005453-4057qib7 9311 5 . . . cord-005453-4057qib7 9312 1 Conclusions conclusion NNS cord-005453-4057qib7 9312 2 : : : cord-005453-4057qib7 9313 1 We -PRON- PRP cord-005453-4057qib7 9313 2 observed observe VBD cord-005453-4057qib7 9313 3 a a DT cord-005453-4057qib7 9313 4 potential potential JJ cord-005453-4057qib7 9313 5 association association NN cord-005453-4057qib7 9313 6 of of IN cord-005453-4057qib7 9313 7 4 4 CD cord-005453-4057qib7 9313 8 EVs evs NN cord-005453-4057qib7 9313 9 membrane membrane NN cord-005453-4057qib7 9313 10 proteins protein NNS cord-005453-4057qib7 9313 11 with with IN cord-005453-4057qib7 9313 12 CMV CMV NNP cord-005453-4057qib7 9313 13 reactivation reactivation NN cord-005453-4057qib7 9313 14 : : : cord-005453-4057qib7 9313 15 CD140a CD140a NNP cord-005453-4057qib7 9313 16 , , , cord-005453-4057qib7 9313 17 CD30 CD30 NNP cord-005453-4057qib7 9313 18 , , , cord-005453-4057qib7 9313 19 CD144 CD144 NNP cord-005453-4057qib7 9313 20 and and CC cord-005453-4057qib7 9313 21 CD31 CD31 NNP cord-005453-4057qib7 9313 22 . . . cord-005453-4057qib7 9314 1 These these DT cord-005453-4057qib7 9314 2 proteins protein NNS cord-005453-4057qib7 9314 3 are be VBP cord-005453-4057qib7 9314 4 crucial crucial JJ cord-005453-4057qib7 9314 5 for for IN cord-005453-4057qib7 9314 6 endothelium endothelium NN cord-005453-4057qib7 9314 7 and and CC cord-005453-4057qib7 9314 8 immune immune JJ cord-005453-4057qib7 9314 9 cells cell NNS cord-005453-4057qib7 9314 10 interaction interaction NN cord-005453-4057qib7 9314 11 . . . cord-005453-4057qib7 9315 1 CMV CMV NNP cord-005453-4057qib7 9315 2 can can MD cord-005453-4057qib7 9315 3 infect infect VB cord-005453-4057qib7 9315 4 different different JJ cord-005453-4057qib7 9315 5 cell cell NN cord-005453-4057qib7 9315 6 types type NNS cord-005453-4057qib7 9315 7 including include VBG cord-005453-4057qib7 9315 8 endothelial endothelial JJ cord-005453-4057qib7 9315 9 cells cell NNS cord-005453-4057qib7 9315 10 ( ( -LRB- cord-005453-4057qib7 9315 11 Bentz Bentz NNP cord-005453-4057qib7 9315 12 GL GL NNP cord-005453-4057qib7 9315 13 . . . cord-005453-4057qib7 9316 1 PNAS PNAS NNP cord-005453-4057qib7 9316 2 105 105 CD cord-005453-4057qib7 9316 3 ( ( -LRB- cord-005453-4057qib7 9316 4 14 14 CD cord-005453-4057qib7 9316 5 ) ) -RRB- cord-005453-4057qib7 9316 6 2008 2008 CD cord-005453-4057qib7 9316 7 ) ) -RRB- cord-005453-4057qib7 9316 8 . . . cord-005453-4057qib7 9317 1 Moreover moreover RB cord-005453-4057qib7 9317 2 , , , cord-005453-4057qib7 9317 3 CD140a CD140a NNP cord-005453-4057qib7 9317 4 ( ( -LRB- cord-005453-4057qib7 9317 5 PDGFR PDGFR NNP cord-005453-4057qib7 9317 6 - - HYPH cord-005453-4057qib7 9317 7 α α NNP cord-005453-4057qib7 9317 8 ) ) -RRB- cord-005453-4057qib7 9317 9 has have VBZ cord-005453-4057qib7 9317 10 been be VBN cord-005453-4057qib7 9317 11 shown show VBN cord-005453-4057qib7 9317 12 to to TO cord-005453-4057qib7 9317 13 function function VB cord-005453-4057qib7 9317 14 as as IN cord-005453-4057qib7 9317 15 an an DT cord-005453-4057qib7 9317 16 entry entry NN cord-005453-4057qib7 9317 17 receptor receptor NN cord-005453-4057qib7 9317 18 for for IN cord-005453-4057qib7 9317 19 CMV CMV NNP cord-005453-4057qib7 9317 20 expressing express VBG cord-005453-4057qib7 9318 1 gH gH NNP cord-005453-4057qib7 9318 2 / / SYM cord-005453-4057qib7 9318 3 gL gL NNP cord-005453-4057qib7 9318 4 / / SYM cord-005453-4057qib7 9318 5 gO go VB cord-005453-4057qib7 9318 6 complex complex JJ cord-005453-4057qib7 9319 1 ( ( -LRB- cord-005453-4057qib7 9319 2 Wu Wu NNP cord-005453-4057qib7 9319 3 Y. Y. NNP cord-005453-4057qib7 9319 4 et et NNP cord-005453-4057qib7 9319 5 al al NNP cord-005453-4057qib7 9319 6 . . . cord-005453-4057qib7 9320 1 PLoS PLoS NNP cord-005453-4057qib7 9320 2 Pathog Pathog NNP cord-005453-4057qib7 9320 3 13 13 CD cord-005453-4057qib7 9320 4 ( ( -LRB- cord-005453-4057qib7 9320 5 4 4 CD cord-005453-4057qib7 9320 6 ) ) -RRB- cord-005453-4057qib7 9320 7 2017 2017 CD cord-005453-4057qib7 9320 8 ) ) -RRB- cord-005453-4057qib7 9320 9 . . . cord-005453-4057qib7 9321 1 We -PRON- PRP cord-005453-4057qib7 9321 2 plan plan VBP cord-005453-4057qib7 9321 3 to to TO cord-005453-4057qib7 9321 4 implement implement VB cord-005453-4057qib7 9321 5 our -PRON- PRP$ cord-005453-4057qib7 9321 6 analysis analysis NN cord-005453-4057qib7 9321 7 characterizing characterize VBG cord-005453-4057qib7 9321 8 EVs EVs NNP cord-005453-4057qib7 9321 9 contents content NNS cord-005453-4057qib7 9321 10 ( ( -LRB- cord-005453-4057qib7 9321 11 miRNAs miRNAs NNP cord-005453-4057qib7 9321 12 ) ) -RRB- cord-005453-4057qib7 9321 13 and and CC cord-005453-4057qib7 9321 14 will will MD cord-005453-4057qib7 9321 15 be be VB cord-005453-4057qib7 9321 16 applied apply VBN cord-005453-4057qib7 9321 17 to to TO cord-005453-4057qib7 9321 18 investigate investigate VB cord-005453-4057qib7 9321 19 other other JJ cord-005453-4057qib7 9321 20 viral viral JJ cord-005453-4057qib7 9321 21 reactivations reactivation NNS cord-005453-4057qib7 9321 22 ( ( -LRB- cord-005453-4057qib7 9321 23 e.g. e.g. RB cord-005453-4057qib7 9321 24 Epstein Epstein NNP cord-005453-4057qib7 9321 25 Barr Barr NNP cord-005453-4057qib7 9321 26 Virus Virus NNP cord-005453-4057qib7 9321 27 and and CC cord-005453-4057qib7 9321 28 Human Human NNP cord-005453-4057qib7 9321 29 Herpes Herpes NNP cord-005453-4057qib7 9321 30 Virus Virus NNP cord-005453-4057qib7 9321 31 6 6 CD cord-005453-4057qib7 9321 32 ) ) -RRB- cord-005453-4057qib7 9321 33 . . . cord-005453-4057qib7 9322 1 [ [ -LRB- cord-005453-4057qib7 9322 2 [ [ -LRB- cord-005453-4057qib7 9322 3 P414 P414 NNP cord-005453-4057qib7 9322 4 Image image NN cord-005453-4057qib7 9322 5 ] ] -RRB- cord-005453-4057qib7 9322 6 1 1 CD cord-005453-4057qib7 9322 7 . . . cord-005453-4057qib7 9323 1 Methods method NNS cord-005453-4057qib7 9323 2 : : : cord-005453-4057qib7 9323 3 To to TO cord-005453-4057qib7 9323 4 explore explore VB cord-005453-4057qib7 9323 5 the the DT cord-005453-4057qib7 9323 6 value value NN cord-005453-4057qib7 9323 7 of of IN cord-005453-4057qib7 9323 8 CMV CMV NNP cord-005453-4057qib7 9323 9 DNA DNA NNP cord-005453-4057qib7 9323 10 extracted extract VBN cord-005453-4057qib7 9323 11 from from IN cord-005453-4057qib7 9323 12 GI GI NNP cord-005453-4057qib7 9323 13 tissue tissue NN cord-005453-4057qib7 9323 14 for for IN cord-005453-4057qib7 9323 15 the the DT cord-005453-4057qib7 9323 16 diagnosis diagnosis NN cord-005453-4057qib7 9323 17 of of IN cord-005453-4057qib7 9323 18 CMV CMV NNP cord-005453-4057qib7 9323 19 gastroenteritis gastroenteritis NN cord-005453-4057qib7 9323 20 , , , cord-005453-4057qib7 9323 21 we -PRON- PRP cord-005453-4057qib7 9323 22 retrospectively retrospectively RB cord-005453-4057qib7 9323 23 evaluated evaluate VBD cord-005453-4057qib7 9323 24 71 71 CD cord-005453-4057qib7 9323 25 patients patient NNS cord-005453-4057qib7 9323 26 , , , cord-005453-4057qib7 9323 27 aged aged JJ cord-005453-4057qib7 9323 28 17 17 CD cord-005453-4057qib7 9323 29 - - SYM cord-005453-4057qib7 9323 30 67 67 CD cord-005453-4057qib7 9323 31 ( ( -LRB- cord-005453-4057qib7 9323 32 median median JJ cord-005453-4057qib7 9323 33 44.8 44.8 CD cord-005453-4057qib7 9323 34 years year NNS cord-005453-4057qib7 9323 35 ) ) -RRB- cord-005453-4057qib7 9323 36 who who WP cord-005453-4057qib7 9323 37 received receive VBD cord-005453-4057qib7 9323 38 allo allo NN cord-005453-4057qib7 9323 39 - - HYPH cord-005453-4057qib7 9323 40 HCT hct NN cord-005453-4057qib7 9323 41 from from IN cord-005453-4057qib7 9323 42 sibling(26 sibling(26 NNP cord-005453-4057qib7 9323 43 ) ) -RRB- cord-005453-4057qib7 9323 44 , , , cord-005453-4057qib7 9323 45 matched match VBN cord-005453-4057qib7 9323 46 unrelated(40 unrelated(40 NNP cord-005453-4057qib7 9323 47 ) ) -RRB- cord-005453-4057qib7 9323 48 or or CC cord-005453-4057qib7 9323 49 haploidentical haploidentical NNP cord-005453-4057qib7 9323 50 donors(5 donors(5 NNP cord-005453-4057qib7 9323 51 ) ) -RRB- cord-005453-4057qib7 9323 52 , , , cord-005453-4057qib7 9323 53 after after IN cord-005453-4057qib7 9323 54 receiving receive VBG cord-005453-4057qib7 9323 55 myeloablative myeloablative NNP cord-005453-4057qib7 9323 56 ( ( -LRB- cord-005453-4057qib7 9323 57 56 56 CD cord-005453-4057qib7 9323 58 ) ) -RRB- cord-005453-4057qib7 9323 59 or or CC cord-005453-4057qib7 9323 60 reduced reduce VBN cord-005453-4057qib7 9323 61 intensity intensity NN cord-005453-4057qib7 9323 62 conditioning(15 conditioning(15 NNP cord-005453-4057qib7 9323 63 ) ) -RRB- cord-005453-4057qib7 9323 64 . . . cord-005453-4057qib7 9324 1 They -PRON- PRP cord-005453-4057qib7 9324 2 all all DT cord-005453-4057qib7 9324 3 underwent undergo VBD cord-005453-4057qib7 9324 4 endoscopy endoscopy NN cord-005453-4057qib7 9324 5 for for IN cord-005453-4057qib7 9324 6 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 9324 7 symptoms symptom NNS cord-005453-4057qib7 9324 8 between between IN cord-005453-4057qib7 9324 9 2012 2012 CD cord-005453-4057qib7 9324 10 - - SYM cord-005453-4057qib7 9324 11 2018 2018 CD cord-005453-4057qib7 9324 12 . . . cord-005453-4057qib7 9325 1 CMV CMV NNP cord-005453-4057qib7 9325 2 DNA DNA NNP cord-005453-4057qib7 9325 3 from from IN cord-005453-4057qib7 9325 4 tissue tissue NN cord-005453-4057qib7 9325 5 samples sample NNS cord-005453-4057qib7 9325 6 and and CC cord-005453-4057qib7 9325 7 parallel parallel JJ cord-005453-4057qib7 9325 8 blood blood NN cord-005453-4057qib7 9325 9 samples sample NNS cord-005453-4057qib7 9325 10 were be VBD cord-005453-4057qib7 9325 11 measured measure VBN cord-005453-4057qib7 9325 12 by by IN cord-005453-4057qib7 9325 13 Q Q NNP cord-005453-4057qib7 9325 14 - - HYPH cord-005453-4057qib7 9325 15 PCR PCR NNP cord-005453-4057qib7 9325 16 . . . cord-005453-4057qib7 9326 1 Positive positive JJ cord-005453-4057qib7 9326 2 CMV CMV NNP cord-005453-4057qib7 9326 3 DNA dna NN cord-005453-4057qib7 9326 4 on on IN cord-005453-4057qib7 9326 5 the the DT cord-005453-4057qib7 9326 6 tissue tissue NN cord-005453-4057qib7 9326 7 was be VBD cord-005453-4057qib7 9326 8 considered consider VBN cord-005453-4057qib7 9326 9 CMV CMV NNP cord-005453-4057qib7 9326 10 GI GI NNP cord-005453-4057qib7 9326 11 infection infection NN cord-005453-4057qib7 9326 12 . . . cord-005453-4057qib7 9327 1 CMV CMV NNP cord-005453-4057qib7 9327 2 GI GI NNP cord-005453-4057qib7 9327 3 disease disease NN cord-005453-4057qib7 9327 4 was be VBD cord-005453-4057qib7 9327 5 proven prove VBN cord-005453-4057qib7 9327 6 with with IN cord-005453-4057qib7 9327 7 the the DT cord-005453-4057qib7 9327 8 identification identification NN cord-005453-4057qib7 9327 9 of of IN cord-005453-4057qib7 9327 10 CMV CMV NNP cord-005453-4057qib7 9327 11 inclusion inclusion NN cord-005453-4057qib7 9327 12 bodies body NNS cord-005453-4057qib7 9327 13 or or CC cord-005453-4057qib7 9327 14 positive positive JJ cord-005453-4057qib7 9327 15 immunehistochemical immunehistochemical JJ cord-005453-4057qib7 9327 16 staining staining NN cord-005453-4057qib7 9327 17 using use VBG cord-005453-4057qib7 9327 18 anti anti JJ cord-005453-4057qib7 9327 19 - - JJ cord-005453-4057qib7 9327 20 CMV CMV NNP cord-005453-4057qib7 9327 21 antibodies antibody NNS cord-005453-4057qib7 9327 22 . . . cord-005453-4057qib7 9328 1 Results result NNS cord-005453-4057qib7 9328 2 : : : cord-005453-4057qib7 9329 1 Overall overall RB cord-005453-4057qib7 9329 2 , , , cord-005453-4057qib7 9329 3 91 91 CD cord-005453-4057qib7 9329 4 endoscopic endoscopic JJ cord-005453-4057qib7 9329 5 tests test NNS cord-005453-4057qib7 9329 6 were be VBD cord-005453-4057qib7 9329 7 performed perform VBN cord-005453-4057qib7 9329 8 ( ( -LRB- cord-005453-4057qib7 9329 9 55 55 CD cord-005453-4057qib7 9329 10 gastro-,36 gastro-,36 CD cord-005453-4057qib7 9329 11 colonoscopies colonoscopy NNS cord-005453-4057qib7 9329 12 ) ) -RRB- cord-005453-4057qib7 9329 13 at at IN cord-005453-4057qib7 9329 14 a a DT cord-005453-4057qib7 9329 15 median median NN cord-005453-4057qib7 9329 16 of of IN cord-005453-4057qib7 9329 17 73 73 CD cord-005453-4057qib7 9329 18 days day NNS cord-005453-4057qib7 9329 19 ( ( -LRB- cord-005453-4057qib7 9329 20 IQR:145 IQR:145 NNP cord-005453-4057qib7 9329 21 ) ) -RRB- cord-005453-4057qib7 9329 22 post post NN cord-005453-4057qib7 9329 23 transplantation transplantation NN cord-005453-4057qib7 9329 24 . . . cord-005453-4057qib7 9330 1 Symptoms symptom NNS cord-005453-4057qib7 9330 2 included include VBD cord-005453-4057qib7 9330 3 nausea nausea NN cord-005453-4057qib7 9330 4 , , , cord-005453-4057qib7 9330 5 vomiting vomiting NN cord-005453-4057qib7 9330 6 , , , cord-005453-4057qib7 9330 7 diarrhea diarrhea NN cord-005453-4057qib7 9330 8 , , , cord-005453-4057qib7 9330 9 abdominal abdominal JJ cord-005453-4057qib7 9330 10 pain pain NN cord-005453-4057qib7 9330 11 and and CC cord-005453-4057qib7 9330 12 weight weight NN cord-005453-4057qib7 9330 13 loss loss NN cord-005453-4057qib7 9330 14 . . . cord-005453-4057qib7 9331 1 CMV CMV NNP cord-005453-4057qib7 9331 2 DNA DNA NNP cord-005453-4057qib7 9331 3 was be VBD cord-005453-4057qib7 9331 4 positive positive JJ cord-005453-4057qib7 9331 5 in in IN cord-005453-4057qib7 9331 6 41/91 41/91 CD cord-005453-4057qib7 9331 7 tissue tissue NN cord-005453-4057qib7 9331 8 samples sample NNS cord-005453-4057qib7 9331 9 : : : cord-005453-4057qib7 9332 1 median median JJ cord-005453-4057qib7 9332 2 536 536 CD cord-005453-4057qib7 9332 3 copies copy NNS cord-005453-4057qib7 9332 4 / / SYM cord-005453-4057qib7 9332 5 ml ml NN cord-005453-4057qib7 9332 6 , , , cord-005453-4057qib7 9332 7 range range NN cord-005453-4057qib7 9332 8 : : : cord-005453-4057qib7 9332 9 11 11 CD cord-005453-4057qib7 9332 10 - - HYPH cord-005453-4057qib7 9332 11 131x10 131x10 CD cord-005453-4057qib7 9332 12 ^ ^ SYM cord-005453-4057qib7 9332 13 6 6 CD cord-005453-4057qib7 9332 14 . . . cord-005453-4057qib7 9333 1 Only only RB cord-005453-4057qib7 9333 2 half half JJ cord-005453-4057qib7 9333 3 patients patient NNS cord-005453-4057qib7 9333 4 ( ( -LRB- cord-005453-4057qib7 9333 5 22/41 22/41 CD cord-005453-4057qib7 9333 6 ) ) -RRB- cord-005453-4057qib7 9333 7 had have VBD cord-005453-4057qib7 9333 8 concurrent concurrent JJ cord-005453-4057qib7 9333 9 CMV CMV NNP cord-005453-4057qib7 9333 10 viremia viremia NN cord-005453-4057qib7 9333 11 ( ( -LRB- cord-005453-4057qib7 9333 12 plasma plasma NN cord-005453-4057qib7 9333 13 viral viral JJ cord-005453-4057qib7 9333 14 load>100c load>100c NNP cord-005453-4057qib7 9333 15 / / SYM cord-005453-4057qib7 9333 16 ml ml NN cord-005453-4057qib7 9333 17 ) ) -RRB- cord-005453-4057qib7 9333 18 . . . cord-005453-4057qib7 9334 1 CMV CMV NNP cord-005453-4057qib7 9334 2 GI GI NNP cord-005453-4057qib7 9334 3 infection infection NN cord-005453-4057qib7 9334 4 was be VBD cord-005453-4057qib7 9334 5 not not RB cord-005453-4057qib7 9334 6 correlated correlate VBN cord-005453-4057qib7 9334 7 to to IN cord-005453-4057qib7 9334 8 the the DT cord-005453-4057qib7 9334 9 type type NN cord-005453-4057qib7 9334 10 of of IN cord-005453-4057qib7 9334 11 transplant transplant NN cord-005453-4057qib7 9334 12 , , , cord-005453-4057qib7 9334 13 acute acute JJ cord-005453-4057qib7 9334 14 or or CC cord-005453-4057qib7 9334 15 chronic chronic JJ cord-005453-4057qib7 9334 16 GvHD gvhd NN cord-005453-4057qib7 9334 17 . . . cord-005453-4057qib7 9335 1 GI GI NNP cord-005453-4057qib7 9335 2 CMV CMV NNP cord-005453-4057qib7 9335 3 disease disease NN cord-005453-4057qib7 9335 4 was be VBD cord-005453-4057qib7 9335 5 documented document VBN cord-005453-4057qib7 9335 6 by by IN cord-005453-4057qib7 9335 7 biopsy biopsy NN cord-005453-4057qib7 9335 8 in in IN cord-005453-4057qib7 9335 9 13 13 CD cord-005453-4057qib7 9335 10 patients patient NNS cord-005453-4057qib7 9335 11 . . . cord-005453-4057qib7 9336 1 CMV CMV NNP cord-005453-4057qib7 9336 2 DNA DNA NNP cord-005453-4057qib7 9336 3 of of IN cord-005453-4057qib7 9336 4 the the DT cord-005453-4057qib7 9336 5 tissue tissue NN cord-005453-4057qib7 9336 6 , , , cord-005453-4057qib7 9336 7 but but CC cord-005453-4057qib7 9336 8 not not RB cord-005453-4057qib7 9336 9 the the DT cord-005453-4057qib7 9336 10 plasma plasma NN cord-005453-4057qib7 9336 11 viral viral JJ cord-005453-4057qib7 9336 12 load load NN cord-005453-4057qib7 9336 13 , , , cord-005453-4057qib7 9336 14 was be VBD cord-005453-4057qib7 9336 15 a a DT cord-005453-4057qib7 9336 16 predictor predictor NN cord-005453-4057qib7 9336 17 of of IN cord-005453-4057qib7 9336 18 biopsy biopsy NN cord-005453-4057qib7 9336 19 positivity positivity NN cord-005453-4057qib7 9336 20 ( ( -LRB- cord-005453-4057qib7 9336 21 OR or NN cord-005453-4057qib7 9336 22 : : : cord-005453-4057qib7 9336 23 1.6 1.6 CD cord-005453-4057qib7 9336 24 , , , cord-005453-4057qib7 9336 25 95%CI 95%ci CD cord-005453-4057qib7 9336 26 : : SYM cord-005453-4057qib7 9336 27 1.1 1.1 CD cord-005453-4057qib7 9336 28 - - SYM cord-005453-4057qib7 9336 29 1.8 1.8 CD cord-005453-4057qib7 9336 30 , , , cord-005453-4057qib7 9336 31 p=0.006 p=0.006 NNS cord-005453-4057qib7 9336 32 ) ) -RRB- cord-005453-4057qib7 9336 33 . . . cord-005453-4057qib7 9337 1 Thirty thirty CD cord-005453-4057qib7 9337 2 - - HYPH cord-005453-4057qib7 9337 3 six six CD cord-005453-4057qib7 9337 4 out out IN cord-005453-4057qib7 9337 5 of of IN cord-005453-4057qib7 9337 6 41 41 CD cord-005453-4057qib7 9337 7 CMV CMV NNP cord-005453-4057qib7 9337 8 DNA DNA NNP cord-005453-4057qib7 9337 9 positive positive JJ cord-005453-4057qib7 9337 10 patients patient NNS cord-005453-4057qib7 9337 11 received receive VBD cord-005453-4057qib7 9337 12 specific specific JJ cord-005453-4057qib7 9337 13 treatment treatment NN cord-005453-4057qib7 9337 14 for for IN cord-005453-4057qib7 9337 15 at at RB cord-005453-4057qib7 9337 16 least least RBS cord-005453-4057qib7 9337 17 10 10 CD cord-005453-4057qib7 9337 18 days day NNS cord-005453-4057qib7 9337 19 . . . cord-005453-4057qib7 9338 1 Symptoms symptom NNS cord-005453-4057qib7 9338 2 resolved resolve VBD cord-005453-4057qib7 9338 3 in in IN cord-005453-4057qib7 9338 4 21/36 21/36 CD cord-005453-4057qib7 9338 5 patients patient NNS cord-005453-4057qib7 9338 6 ( ( -LRB- cord-005453-4057qib7 9338 7 60 60 CD cord-005453-4057qib7 9338 8 % % NN cord-005453-4057qib7 9338 9 ) ) -RRB- cord-005453-4057qib7 9338 10 and and CC cord-005453-4057qib7 9338 11 the the DT cord-005453-4057qib7 9338 12 GI GI NNP cord-005453-4057qib7 9338 13 viral viral JJ cord-005453-4057qib7 9338 14 load load NN cord-005453-4057qib7 9338 15 was be VBD cord-005453-4057qib7 9338 16 not not RB cord-005453-4057qib7 9338 17 a a DT cord-005453-4057qib7 9338 18 significant significant JJ cord-005453-4057qib7 9338 19 factor factor NN cord-005453-4057qib7 9338 20 to to TO cord-005453-4057qib7 9338 21 predict predict VB cord-005453-4057qib7 9338 22 cure cure NN cord-005453-4057qib7 9338 23 . . . cord-005453-4057qib7 9339 1 GI GI NNP cord-005453-4057qib7 9339 2 GvHD GvHD NNP cord-005453-4057qib7 9339 3 was be VBD cord-005453-4057qib7 9339 4 diagnosed diagnose VBN cord-005453-4057qib7 9339 5 in in IN cord-005453-4057qib7 9339 6 42/91 42/91 CD cord-005453-4057qib7 9339 7 patients patient NNS cord-005453-4057qib7 9339 8 , , , cord-005453-4057qib7 9339 9 among among IN cord-005453-4057qib7 9339 10 which which WDT cord-005453-4057qib7 9339 11 45%(19/42 45%(19/42 CD cord-005453-4057qib7 9339 12 ) ) -RRB- cord-005453-4057qib7 9339 13 with with IN cord-005453-4057qib7 9339 14 CMV CMV NNP cord-005453-4057qib7 9339 15 DNA dna NN cord-005453-4057qib7 9339 16 positivity positivity NN cord-005453-4057qib7 9339 17 . . . cord-005453-4057qib7 9340 1 Median median JJ cord-005453-4057qib7 9340 2 OS OS NNP cord-005453-4057qib7 9340 3 was be VBD cord-005453-4057qib7 9340 4 453 453 CD cord-005453-4057qib7 9340 5 days day NNS cord-005453-4057qib7 9340 6 ( ( -LRB- cord-005453-4057qib7 9340 7 95%CI 95%ci CD cord-005453-4057qib7 9340 8 : : : cord-005453-4057qib7 9340 9 297 297 CD cord-005453-4057qib7 9340 10 - - SYM cord-005453-4057qib7 9340 11 608 608 CD cord-005453-4057qib7 9340 12 ) ) -RRB- cord-005453-4057qib7 9340 13 for for IN cord-005453-4057qib7 9340 14 patients patient NNS cord-005453-4057qib7 9340 15 with with IN cord-005453-4057qib7 9340 16 CMV CMV NNP cord-005453-4057qib7 9340 17 infection infection NN cord-005453-4057qib7 9340 18 , , , cord-005453-4057qib7 9340 19 similar similar JJ cord-005453-4057qib7 9340 20 to to IN cord-005453-4057qib7 9340 21 those those DT cord-005453-4057qib7 9340 22 without without IN cord-005453-4057qib7 9340 23 ( ( -LRB- cord-005453-4057qib7 9340 24 median median JJ cord-005453-4057qib7 9340 25 OS os NN cord-005453-4057qib7 9340 26 : : : cord-005453-4057qib7 9340 27 890 890 CD cord-005453-4057qib7 9340 28 , , , cord-005453-4057qib7 9340 29 95%CI 95%ci CD cord-005453-4057qib7 9340 30 : : : cord-005453-4057qib7 9340 31 80 80 CD cord-005453-4057qib7 9340 32 - - SYM cord-005453-4057qib7 9340 33 1699 1699 CD cord-005453-4057qib7 9340 34 days day NNS cord-005453-4057qib7 9340 35 , , , cord-005453-4057qib7 9340 36 p p NN cord-005453-4057qib7 9340 37 = = SYM cord-005453-4057qib7 9340 38 ns ns NNP cord-005453-4057qib7 9340 39 ) ) -RRB- cord-005453-4057qib7 9340 40 . . . cord-005453-4057qib7 9341 1 We -PRON- PRP cord-005453-4057qib7 9341 2 studied study VBD cord-005453-4057qib7 9341 3 separately separately RB cord-005453-4057qib7 9341 4 endoscopies endoscopy NNS cord-005453-4057qib7 9341 5 of of IN cord-005453-4057qib7 9341 6 the the DT cord-005453-4057qib7 9341 7 upper upper JJ cord-005453-4057qib7 9341 8 ( ( -LRB- cord-005453-4057qib7 9341 9 55/91 55/91 CD cord-005453-4057qib7 9341 10 ) ) -RRB- cord-005453-4057qib7 9341 11 or or CC cord-005453-4057qib7 9341 12 lower low JJR cord-005453-4057qib7 9341 13 GI GI NNP cord-005453-4057qib7 9341 14 tract tract NN cord-005453-4057qib7 9341 15 ( ( -LRB- cord-005453-4057qib7 9341 16 36/91 36/91 CD cord-005453-4057qib7 9341 17 ) ) -RRB- cord-005453-4057qib7 9341 18 . . . cord-005453-4057qib7 9342 1 There there EX cord-005453-4057qib7 9342 2 was be VBD cord-005453-4057qib7 9342 3 no no DT cord-005453-4057qib7 9342 4 significant significant JJ cord-005453-4057qib7 9342 5 relationship relationship NN cord-005453-4057qib7 9342 6 between between IN cord-005453-4057qib7 9342 7 CMV CMV NNP cord-005453-4057qib7 9342 8 gastritis gastritis NN cord-005453-4057qib7 9342 9 proven prove VBN cord-005453-4057qib7 9342 10 by by IN cord-005453-4057qib7 9342 11 biopsy biopsy NN cord-005453-4057qib7 9342 12 and and CC cord-005453-4057qib7 9342 13 CMV CMV NNP cord-005453-4057qib7 9342 14 DNA DNA NNP cord-005453-4057qib7 9342 15 levels level NNS cord-005453-4057qib7 9342 16 in in IN cord-005453-4057qib7 9342 17 gastric gastric JJ cord-005453-4057qib7 9342 18 tissue tissue NN cord-005453-4057qib7 9342 19 . . . cord-005453-4057qib7 9343 1 However however RB cord-005453-4057qib7 9343 2 , , , cord-005453-4057qib7 9343 3 the the DT cord-005453-4057qib7 9343 4 viral viral JJ cord-005453-4057qib7 9343 5 load load NN cord-005453-4057qib7 9343 6 of of IN cord-005453-4057qib7 9343 7 the the DT cord-005453-4057qib7 9343 8 colon colon NN cord-005453-4057qib7 9343 9 was be VBD cord-005453-4057qib7 9343 10 a a DT cord-005453-4057qib7 9343 11 predictor predictor NN cord-005453-4057qib7 9343 12 of of IN cord-005453-4057qib7 9343 13 CMV CMV NNP cord-005453-4057qib7 9343 14 enteritis enteritis NN cord-005453-4057qib7 9343 15 ( ( -LRB- cord-005453-4057qib7 9343 16 OR or NN cord-005453-4057qib7 9343 17 : : : cord-005453-4057qib7 9343 18 1.9 1.9 CD cord-005453-4057qib7 9343 19 , , , cord-005453-4057qib7 9343 20 95%CI 95%ci CD cord-005453-4057qib7 9343 21 : : : cord-005453-4057qib7 9343 22 1.9 1.9 CD cord-005453-4057qib7 9343 23 - - SYM cord-005453-4057qib7 9343 24 3 3 CD cord-005453-4057qib7 9343 25 , , , cord-005453-4057qib7 9343 26 p=0.007 p=0.007 NNP cord-005453-4057qib7 9343 27 ) ) -RRB- cord-005453-4057qib7 9343 28 . . . cord-005453-4057qib7 9344 1 The the DT cord-005453-4057qib7 9344 2 AUROC AUROC NNP cord-005453-4057qib7 9344 3 of of IN cord-005453-4057qib7 9344 4 the the DT cord-005453-4057qib7 9344 5 Q Q NNP cord-005453-4057qib7 9344 6 - - HYPH cord-005453-4057qib7 9344 7 PCR PCR NNP cord-005453-4057qib7 9344 8 was be VBD cord-005453-4057qib7 9344 9 0.849 0.849 CD cord-005453-4057qib7 9345 1 ( ( -LRB- cord-005453-4057qib7 9345 2 95%CI 95%ci CD cord-005453-4057qib7 9345 3 : : : cord-005453-4057qib7 9345 4 0.659 0.659 CD cord-005453-4057qib7 9345 5 to to IN cord-005453-4057qib7 9345 6 1 1 CD cord-005453-4057qib7 9345 7 ) ) -RRB- cord-005453-4057qib7 9345 8 , , , cord-005453-4057qib7 9345 9 the the DT cord-005453-4057qib7 9345 10 sensitivity sensitivity NN cord-005453-4057qib7 9345 11 was be VBD cord-005453-4057qib7 9345 12 85.7 85.7 CD cord-005453-4057qib7 9345 13 % % NN cord-005453-4057qib7 9345 14 and and CC cord-005453-4057qib7 9345 15 the the DT cord-005453-4057qib7 9345 16 specificity specificity NN cord-005453-4057qib7 9345 17 was be VBD cord-005453-4057qib7 9345 18 78.6 78.6 CD cord-005453-4057qib7 9345 19 % % NN cord-005453-4057qib7 9345 20 with with IN cord-005453-4057qib7 9345 21 a a DT cord-005453-4057qib7 9345 22 cutoff cutoff NN cord-005453-4057qib7 9345 23 value value NN cord-005453-4057qib7 9345 24 of of IN cord-005453-4057qib7 9345 25 370 370 CD cord-005453-4057qib7 9345 26 copies copy NNS cord-005453-4057qib7 9345 27 / / SYM cord-005453-4057qib7 9345 28 ml ml NN cord-005453-4057qib7 9345 29 DNA dna NN cord-005453-4057qib7 9345 30 . . . cord-005453-4057qib7 9346 1 Conclusions conclusion NNS cord-005453-4057qib7 9346 2 : : : cord-005453-4057qib7 9347 1 Pathognomonic Pathognomonic NNP cord-005453-4057qib7 9347 2 findings finding NNS cord-005453-4057qib7 9347 3 in in IN cord-005453-4057qib7 9347 4 the the DT cord-005453-4057qib7 9347 5 biopsy biopsy NN cord-005453-4057qib7 9347 6 remain remain VBP cord-005453-4057qib7 9347 7 the the DT cord-005453-4057qib7 9347 8 gold gold NN cord-005453-4057qib7 9347 9 standard standard NN cord-005453-4057qib7 9347 10 for for IN cord-005453-4057qib7 9347 11 the the DT cord-005453-4057qib7 9347 12 diagnosis diagnosis NN cord-005453-4057qib7 9347 13 , , , cord-005453-4057qib7 9347 14 especially especially RB cord-005453-4057qib7 9347 15 for for IN cord-005453-4057qib7 9347 16 the the DT cord-005453-4057qib7 9347 17 upper upper JJ cord-005453-4057qib7 9347 18 GI GI NNP cord-005453-4057qib7 9347 19 tract tract NN cord-005453-4057qib7 9347 20 . . . cord-005453-4057qib7 9348 1 However however RB cord-005453-4057qib7 9348 2 , , , cord-005453-4057qib7 9348 3 when when WRB cord-005453-4057qib7 9348 4 the the DT cord-005453-4057qib7 9348 5 lower low JJR cord-005453-4057qib7 9348 6 GI GI NNP cord-005453-4057qib7 9348 7 tract tract NN cord-005453-4057qib7 9348 8 is be VBZ cord-005453-4057qib7 9348 9 involved involve VBN cord-005453-4057qib7 9348 10 , , , cord-005453-4057qib7 9348 11 quantification quantification NN cord-005453-4057qib7 9348 12 of of IN cord-005453-4057qib7 9348 13 CMV CMV NNP cord-005453-4057qib7 9348 14 viral viral JJ cord-005453-4057qib7 9348 15 load load NN cord-005453-4057qib7 9348 16 in in IN cord-005453-4057qib7 9348 17 the the DT cord-005453-4057qib7 9348 18 tissue tissue NN cord-005453-4057qib7 9348 19 may may MD cord-005453-4057qib7 9348 20 be be VB cord-005453-4057qib7 9348 21 a a DT cord-005453-4057qib7 9348 22 valuable valuable JJ cord-005453-4057qib7 9348 23 tool tool NN cord-005453-4057qib7 9348 24 to to TO cord-005453-4057qib7 9348 25 support support VB cord-005453-4057qib7 9348 26 the the DT cord-005453-4057qib7 9348 27 diagnosis diagnosis NN cord-005453-4057qib7 9348 28 . . . cord-005453-4057qib7 9349 1 Positivity positivity NN cord-005453-4057qib7 9349 2 of of IN cord-005453-4057qib7 9349 3 CMV CMV NNP cord-005453-4057qib7 9349 4 DNA DNA NNP cord-005453-4057qib7 9349 5 of of IN cord-005453-4057qib7 9349 6 the the DT cord-005453-4057qib7 9349 7 GI GI NNP cord-005453-4057qib7 9349 8 tissue tissue NN cord-005453-4057qib7 9349 9 , , , cord-005453-4057qib7 9349 10 in in IN cord-005453-4057qib7 9349 11 linearity linearity NN cord-005453-4057qib7 9349 12 to to IN cord-005453-4057qib7 9349 13 the the DT cord-005453-4057qib7 9349 14 CMV CMV NNP cord-005453-4057qib7 9349 15 viremia viremia NN cord-005453-4057qib7 9349 16 , , , cord-005453-4057qib7 9349 17 may may MD cord-005453-4057qib7 9349 18 guide guide VB cord-005453-4057qib7 9349 19 to to IN cord-005453-4057qib7 9349 20 preemptive preemptive JJ cord-005453-4057qib7 9349 21 treatment treatment NN cord-005453-4057qib7 9349 22 for for IN cord-005453-4057qib7 9349 23 prevention prevention NN cord-005453-4057qib7 9349 24 of of IN cord-005453-4057qib7 9349 25 CMV CMV NNP cord-005453-4057qib7 9349 26 disease disease NN cord-005453-4057qib7 9349 27 . . . cord-005453-4057qib7 9350 1 Disclosure disclosure NN cord-005453-4057qib7 9350 2 : : : cord-005453-4057qib7 9350 3 Nothing nothing NN cord-005453-4057qib7 9350 4 to to TO cord-005453-4057qib7 9350 5 declare declare VB cord-005453-4057qib7 9350 6 Background background NN cord-005453-4057qib7 9350 7 : : : cord-005453-4057qib7 9350 8 Clostridium clostridium NN cord-005453-4057qib7 9350 9 difficile difficile NN cord-005453-4057qib7 9350 10 infection infection NN cord-005453-4057qib7 9350 11 ( ( -LRB- cord-005453-4057qib7 9350 12 CDI CDI NNP cord-005453-4057qib7 9350 13 ) ) -RRB- cord-005453-4057qib7 9350 14 is be VBZ cord-005453-4057qib7 9350 15 caused cause VBN cord-005453-4057qib7 9350 16 by by IN cord-005453-4057qib7 9350 17 CD cd NN cord-005453-4057qib7 9350 18 overgrowth overgrowth NN cord-005453-4057qib7 9350 19 in in IN cord-005453-4057qib7 9350 20 antibiotic antibiotic JJ cord-005453-4057qib7 9350 21 - - HYPH cord-005453-4057qib7 9350 22 disturbed disturbed JJ cord-005453-4057qib7 9350 23 intestinal intestinal JJ cord-005453-4057qib7 9350 24 microbiota microbiota NN cord-005453-4057qib7 9350 25 . . . cord-005453-4057qib7 9351 1 Antibiotics antibiotic NNS cord-005453-4057qib7 9351 2 targeting target VBG cord-005453-4057qib7 9351 3 unselectively unselectively RB cord-005453-4057qib7 9351 4 beneficial beneficial JJ cord-005453-4057qib7 9351 5 for for IN cord-005453-4057qib7 9351 6 T t NN cord-005453-4057qib7 9351 7 - - HYPH cord-005453-4057qib7 9351 8 regulatory regulatory JJ cord-005453-4057qib7 9351 9 cell cell NN cord-005453-4057qib7 9351 10 formation formation NN cord-005453-4057qib7 9351 11 strains strain NNS cord-005453-4057qib7 9351 12 of of IN cord-005453-4057qib7 9351 13 Clostridiales Clostridiales NNP cord-005453-4057qib7 9351 14 may may MD cord-005453-4057qib7 9351 15 increase increase VB cord-005453-4057qib7 9351 16 pro pro JJ cord-005453-4057qib7 9351 17 - - JJ cord-005453-4057qib7 9351 18 inflammatory inflammatory JJ cord-005453-4057qib7 9351 19 processes process NNS cord-005453-4057qib7 9351 20 in in IN cord-005453-4057qib7 9351 21 the the DT cord-005453-4057qib7 9351 22 guts gut NNS cord-005453-4057qib7 9351 23 promoting promote VBG cord-005453-4057qib7 9351 24 or or CC cord-005453-4057qib7 9351 25 augmenting augment VBG cord-005453-4057qib7 9351 26 the the DT cord-005453-4057qib7 9351 27 development development NN cord-005453-4057qib7 9351 28 of of IN cord-005453-4057qib7 9351 29 graft graft NN cord-005453-4057qib7 9351 30 vs. vs. FW cord-005453-4057qib7 9351 31 host host NN cord-005453-4057qib7 9351 32 disease disease NN cord-005453-4057qib7 9351 33 ( ( -LRB- cord-005453-4057qib7 9351 34 GVHD GVHD NNP cord-005453-4057qib7 9351 35 ) ) -RRB- cord-005453-4057qib7 9351 36 . . . cord-005453-4057qib7 9352 1 The the DT cord-005453-4057qib7 9352 2 efficacy efficacy NN cord-005453-4057qib7 9352 3 of of IN cord-005453-4057qib7 9352 4 CDI CDI NNP cord-005453-4057qib7 9352 5 treatment treatment NN cord-005453-4057qib7 9352 6 has have VBZ cord-005453-4057qib7 9352 7 impact impact NN cord-005453-4057qib7 9352 8 on on IN cord-005453-4057qib7 9352 9 the the DT cord-005453-4057qib7 9352 10 persistence persistence NN cord-005453-4057qib7 9352 11 of of IN cord-005453-4057qib7 9352 12 inflammation inflammation NN cord-005453-4057qib7 9352 13 which which WDT cord-005453-4057qib7 9352 14 might may MD cord-005453-4057qib7 9352 15 influence influence VB cord-005453-4057qib7 9352 16 the the DT cord-005453-4057qib7 9352 17 alloreactive alloreactive JJ cord-005453-4057qib7 9352 18 reactions reaction NNS cord-005453-4057qib7 9352 19 . . . cord-005453-4057qib7 9353 1 Methods method NNS cord-005453-4057qib7 9353 2 : : : cord-005453-4057qib7 9353 3 We -PRON- PRP cord-005453-4057qib7 9353 4 retrospectively retrospectively RB cord-005453-4057qib7 9353 5 and and CC cord-005453-4057qib7 9353 6 , , , cord-005453-4057qib7 9353 7 from from IN cord-005453-4057qib7 9353 8 2016 2016 CD cord-005453-4057qib7 9353 9 , , , cord-005453-4057qib7 9353 10 prospectively prospectively RB cord-005453-4057qib7 9353 11 analyzed analyze VBD cord-005453-4057qib7 9353 12 the the DT cord-005453-4057qib7 9353 13 data datum NNS cord-005453-4057qib7 9353 14 from from IN cord-005453-4057qib7 9353 15 5 5 CD cord-005453-4057qib7 9353 16 transplant transplant NN cord-005453-4057qib7 9353 17 centers center NNS cord-005453-4057qib7 9353 18 concerning concern VBG cord-005453-4057qib7 9353 19 CDI CDI NNP cord-005453-4057qib7 9353 20 occurrence occurrence NN cord-005453-4057qib7 9353 21 , , , cord-005453-4057qib7 9353 22 treatment treatment NN cord-005453-4057qib7 9353 23 efficacy efficacy NN cord-005453-4057qib7 9353 24 , , , cord-005453-4057qib7 9353 25 and and CC cord-005453-4057qib7 9353 26 GVHD GVHD NNP cord-005453-4057qib7 9353 27 development development NN cord-005453-4057qib7 9353 28 . . . cord-005453-4057qib7 9354 1 The the DT cord-005453-4057qib7 9354 2 study study NN cord-005453-4057qib7 9354 3 included include VBD cord-005453-4057qib7 9354 4 77 77 CD cord-005453-4057qib7 9354 5 patients patient NNS cord-005453-4057qib7 9354 6 with with IN cord-005453-4057qib7 9354 7 hematological hematological JJ cord-005453-4057qib7 9354 8 malignancies malignancy NNS cord-005453-4057qib7 9354 9 who who WP cord-005453-4057qib7 9354 10 underwent undergo VBD cord-005453-4057qib7 9354 11 allogeneic allogeneic JJ cord-005453-4057qib7 9354 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 9354 13 cell cell NN cord-005453-4057qib7 9354 14 transplantation transplantation NN cord-005453-4057qib7 9354 15 ( ( -LRB- cord-005453-4057qib7 9354 16 alloHCT alloHCT NNP cord-005453-4057qib7 9354 17 ) ) -RRB- cord-005453-4057qib7 9354 18 between between IN cord-005453-4057qib7 9354 19 2012 2012 CD cord-005453-4057qib7 9354 20 - - SYM cord-005453-4057qib7 9354 21 2018 2018 CD cord-005453-4057qib7 9354 22 . . . cord-005453-4057qib7 9355 1 Results result NNS cord-005453-4057qib7 9355 2 : : : cord-005453-4057qib7 9356 1 Median median JJ cord-005453-4057qib7 9356 2 time time NN cord-005453-4057qib7 9356 3 to to IN cord-005453-4057qib7 9356 4 CDI CDI NNP cord-005453-4057qib7 9356 5 was be VBD cord-005453-4057qib7 9356 6 14 14 CD cord-005453-4057qib7 9356 7 days day NNS cord-005453-4057qib7 9356 8 post post NN cord-005453-4057qib7 9356 9 - - JJ cord-005453-4057qib7 9356 10 alloHCT allohct JJ cord-005453-4057qib7 9356 11 with with IN cord-005453-4057qib7 9356 12 detection detection NN cord-005453-4057qib7 9356 13 of of IN cord-005453-4057qib7 9356 14 both both DT cord-005453-4057qib7 9356 15 toxins toxin NNS cord-005453-4057qib7 9356 16 A A NNP cord-005453-4057qib7 9356 17 and and CC cord-005453-4057qib7 9356 18 B b NN cord-005453-4057qib7 9356 19 in in IN cord-005453-4057qib7 9356 20 57 57 CD cord-005453-4057qib7 9356 21 % % NN cord-005453-4057qib7 9356 22 of of IN cord-005453-4057qib7 9356 23 cases case NNS cord-005453-4057qib7 9356 24 . . . cord-005453-4057qib7 9357 1 Disturbance disturbance NN cord-005453-4057qib7 9357 2 of of IN cord-005453-4057qib7 9357 3 intestinal intestinal JJ cord-005453-4057qib7 9357 4 microbiome microbiome NN cord-005453-4057qib7 9357 5 was be VBD cord-005453-4057qib7 9357 6 confirmed confirm VBN cord-005453-4057qib7 9357 7 by by IN cord-005453-4057qib7 9357 8 a a DT cord-005453-4057qib7 9357 9 59 59 CD cord-005453-4057qib7 9357 10 % % NN cord-005453-4057qib7 9357 11 rate rate NN cord-005453-4057qib7 9357 12 of of IN cord-005453-4057qib7 9357 13 colonization colonization NN cord-005453-4057qib7 9357 14 with with IN cord-005453-4057qib7 9357 15 multidrug multidrug NN cord-005453-4057qib7 9357 16 - - HYPH cord-005453-4057qib7 9357 17 resistant resistant JJ cord-005453-4057qib7 9357 18 bacteria bacteria NNS cord-005453-4057qib7 9357 19 ( ( -LRB- cord-005453-4057qib7 9357 20 MDRB MDRB NNP cord-005453-4057qib7 9357 21 ) ) -RRB- cord-005453-4057qib7 9357 22 . . . cord-005453-4057qib7 9358 1 The the DT cord-005453-4057qib7 9358 2 CDI CDI NNP cord-005453-4057qib7 9358 3 symptoms symptom NNS cord-005453-4057qib7 9358 4 resolved resolve VBN cord-005453-4057qib7 9358 5 with with IN cord-005453-4057qib7 9358 6 the the DT cord-005453-4057qib7 9358 7 negative negative JJ cord-005453-4057qib7 9358 8 toxins toxin NNS cord-005453-4057qib7 9358 9 after after IN cord-005453-4057qib7 9358 10 the the DT cord-005453-4057qib7 9358 11 first first JJ cord-005453-4057qib7 9358 12 line line NN cord-005453-4057qib7 9358 13 treatment treatment NN cord-005453-4057qib7 9358 14 in in IN cord-005453-4057qib7 9358 15 76.6 76.6 CD cord-005453-4057qib7 9358 16 % % NN cord-005453-4057qib7 9358 17 of of IN cord-005453-4057qib7 9358 18 patients patient NNS cord-005453-4057qib7 9358 19 . . . cord-005453-4057qib7 9359 1 The the DT cord-005453-4057qib7 9359 2 median median JJ cord-005453-4057qib7 9359 3 time time NN cord-005453-4057qib7 9359 4 to to IN cord-005453-4057qib7 9359 5 remission remission NN cord-005453-4057qib7 9359 6 and and CC cord-005453-4057qib7 9359 7 therapy therapy NN cord-005453-4057qib7 9359 8 duration duration NN cord-005453-4057qib7 9359 9 was be VBD cord-005453-4057qib7 9359 10 8 8 CD cord-005453-4057qib7 9359 11 and and CC cord-005453-4057qib7 9359 12 10 10 CD cord-005453-4057qib7 9359 13 days day NNS cord-005453-4057qib7 9359 14 , , , cord-005453-4057qib7 9359 15 respectively respectively RB cord-005453-4057qib7 9359 16 . . . cord-005453-4057qib7 9360 1 Fifteen fifteen CD cord-005453-4057qib7 9360 2 therapeutic therapeutic JJ cord-005453-4057qib7 9360 3 failures failure NNS cord-005453-4057qib7 9360 4 were be VBD cord-005453-4057qib7 9360 5 observed observe VBN cord-005453-4057qib7 9360 6 after after IN cord-005453-4057qib7 9360 7 treatment treatment NN cord-005453-4057qib7 9360 8 with with IN cord-005453-4057qib7 9360 9 metronidazole metronidazole NNP cord-005453-4057qib7 9360 10 ( ( -LRB- cord-005453-4057qib7 9360 11 10 10 CD cord-005453-4057qib7 9360 12 ) ) -RRB- cord-005453-4057qib7 9360 13 , , , cord-005453-4057qib7 9360 14 vancomycin vancomycin FW cord-005453-4057qib7 9360 15 ( ( -LRB- cord-005453-4057qib7 9360 16 2 2 CD cord-005453-4057qib7 9360 17 ) ) -RRB- cord-005453-4057qib7 9360 18 and and CC cord-005453-4057qib7 9360 19 a a DT cord-005453-4057qib7 9360 20 combination combination NN cord-005453-4057qib7 9360 21 therapy therapy NN cord-005453-4057qib7 9360 22 ( ( -LRB- cord-005453-4057qib7 9360 23 3 3 CD cord-005453-4057qib7 9360 24 ) ) -RRB- cord-005453-4057qib7 9360 25 . . . cord-005453-4057qib7 9361 1 Eleven eleven CD cord-005453-4057qib7 9361 2 patients patient NNS cord-005453-4057qib7 9361 3 responded respond VBD cord-005453-4057qib7 9361 4 to to IN cord-005453-4057qib7 9361 5 second second JJ cord-005453-4057qib7 9361 6 line line NN cord-005453-4057qib7 9361 7 treatment treatment NN cord-005453-4057qib7 9361 8 . . . cord-005453-4057qib7 9362 1 Thirty thirty CD cord-005453-4057qib7 9362 2 - - HYPH cord-005453-4057qib7 9362 3 seven seven CD cord-005453-4057qib7 9362 4 ( ( -LRB- cord-005453-4057qib7 9362 5 48 48 CD cord-005453-4057qib7 9362 6 % % NN cord-005453-4057qib7 9362 7 ) ) -RRB- cord-005453-4057qib7 9362 8 patients patient NNS cord-005453-4057qib7 9362 9 died die VBD cord-005453-4057qib7 9362 10 due due IN cord-005453-4057qib7 9362 11 to to IN cord-005453-4057qib7 9362 12 infections infection NNS cord-005453-4057qib7 9362 13 ( ( -LRB- cord-005453-4057qib7 9362 14 17 17 CD cord-005453-4057qib7 9362 15 ) ) -RRB- cord-005453-4057qib7 9362 16 , , , cord-005453-4057qib7 9362 17 relapses relapse NNS cord-005453-4057qib7 9362 18 ( ( -LRB- cord-005453-4057qib7 9362 19 10 10 CD cord-005453-4057qib7 9362 20 ) ) -RRB- cord-005453-4057qib7 9362 21 and and CC cord-005453-4057qib7 9362 22 GVHD GVHD NNP cord-005453-4057qib7 9362 23 / / SYM cord-005453-4057qib7 9362 24 infections infection NNS cord-005453-4057qib7 9362 25 ( ( -LRB- cord-005453-4057qib7 9362 26 10 10 CD cord-005453-4057qib7 9362 27 ) ) -RRB- cord-005453-4057qib7 9362 28 . . . cord-005453-4057qib7 9363 1 We -PRON- PRP cord-005453-4057qib7 9363 2 noted note VBD cord-005453-4057qib7 9363 3 recurrent recurrent JJ cord-005453-4057qib7 9363 4 CDI CDI NNP cord-005453-4057qib7 9363 5 in in IN cord-005453-4057qib7 9363 6 6 6 CD cord-005453-4057qib7 9363 7 cases case NNS cord-005453-4057qib7 9363 8 . . . cord-005453-4057qib7 9364 1 Eight eight CD cord-005453-4057qib7 9364 2 patients patient NNS cord-005453-4057qib7 9364 3 died die VBD cord-005453-4057qib7 9364 4 with with IN cord-005453-4057qib7 9364 5 active active JJ cord-005453-4057qib7 9364 6 CDI CDI NNP cord-005453-4057qib7 9364 7 . . . cord-005453-4057qib7 9365 1 We -PRON- PRP cord-005453-4057qib7 9365 2 observed observe VBD cord-005453-4057qib7 9365 3 occurrence occurrence NN cord-005453-4057qib7 9365 4 or or CC cord-005453-4057qib7 9365 5 exacerbation exacerbation NN cord-005453-4057qib7 9365 6 of of IN cord-005453-4057qib7 9365 7 GVHD GVHD NNP cord-005453-4057qib7 9365 8 in in IN cord-005453-4057qib7 9365 9 35 35 CD cord-005453-4057qib7 9365 10 ( ( -LRB- cord-005453-4057qib7 9365 11 44 44 CD cord-005453-4057qib7 9365 12 % % NN cord-005453-4057qib7 9365 13 ) ) -RRB- cord-005453-4057qib7 9365 14 patients patient NNS cord-005453-4057qib7 9365 15 following follow VBG cord-005453-4057qib7 9365 16 CDI CDI NNP cord-005453-4057qib7 9365 17 , , , cord-005453-4057qib7 9365 18 including include VBG cord-005453-4057qib7 9365 19 25 25 CD cord-005453-4057qib7 9365 20 cases case NNS cord-005453-4057qib7 9365 21 with with IN cord-005453-4057qib7 9365 22 gut gut NN cord-005453-4057qib7 9365 23 involvement involvement NN cord-005453-4057qib7 9365 24 ( ( -LRB- cord-005453-4057qib7 9365 25 GI GI NNP cord-005453-4057qib7 9365 26 - - HYPH cord-005453-4057qib7 9365 27 GVHD GVHD NNP cord-005453-4057qib7 9365 28 ) ) -RRB- cord-005453-4057qib7 9365 29 . . . cord-005453-4057qib7 9366 1 Treatment treatment NN cord-005453-4057qib7 9366 2 with with IN cord-005453-4057qib7 9366 3 metronidazole metronidazole NN cord-005453-4057qib7 9366 4 and and CC cord-005453-4057qib7 9366 5 failure failure NN cord-005453-4057qib7 9366 6 of of IN cord-005453-4057qib7 9366 7 the the DT cord-005453-4057qib7 9366 8 first first JJ cord-005453-4057qib7 9366 9 line line NN cord-005453-4057qib7 9366 10 therapy therapy NN cord-005453-4057qib7 9366 11 increased increase VBD cord-005453-4057qib7 9366 12 the the DT cord-005453-4057qib7 9366 13 development development NN cord-005453-4057qib7 9366 14 or or CC cord-005453-4057qib7 9366 15 escalation escalation NN cord-005453-4057qib7 9366 16 of of IN cord-005453-4057qib7 9366 17 GI GI NNP cord-005453-4057qib7 9366 18 - - HYPH cord-005453-4057qib7 9366 19 GVHD GVHD NNP cord-005453-4057qib7 9366 20 ( ( -LRB- cord-005453-4057qib7 9366 21 p= p= NNP cord-005453-4057qib7 9366 22 0.03 0.03 CD cord-005453-4057qib7 9366 23 and and CC cord-005453-4057qib7 9366 24 p p NN cord-005453-4057qib7 9366 25 < < XX cord-005453-4057qib7 9366 26 0.001 0.001 CD cord-005453-4057qib7 9366 27 , , , cord-005453-4057qib7 9366 28 respectively respectively RB cord-005453-4057qib7 9366 29 ) ) -RRB- cord-005453-4057qib7 9366 30 . . . cord-005453-4057qib7 9367 1 The the DT cord-005453-4057qib7 9367 2 duration duration NN cord-005453-4057qib7 9367 3 of of IN cord-005453-4057qib7 9367 4 CDI CDI NNP cord-005453-4057qib7 9367 5 exceeding exceed VBG cord-005453-4057qib7 9367 6 10 10 CD cord-005453-4057qib7 9367 7 days day NNS cord-005453-4057qib7 9367 8 also also RB cord-005453-4057qib7 9367 9 had have VBD cord-005453-4057qib7 9367 10 impact impact NN cord-005453-4057qib7 9367 11 on on IN cord-005453-4057qib7 9367 12 the the DT cord-005453-4057qib7 9367 13 GI GI NNP cord-005453-4057qib7 9367 14 - - HYPH cord-005453-4057qib7 9367 15 GVHD GVHD NNP cord-005453-4057qib7 9367 16 incidence incidence NN cord-005453-4057qib7 9367 17 ( ( -LRB- cord-005453-4057qib7 9367 18 p= p= NNP cord-005453-4057qib7 9367 19 0.002 0.002 CD cord-005453-4057qib7 9367 20 ) ) -RRB- cord-005453-4057qib7 9367 21 . . . cord-005453-4057qib7 9368 1 Conclusions conclusion NNS cord-005453-4057qib7 9368 2 : : : cord-005453-4057qib7 9368 3 1 1 CD cord-005453-4057qib7 9368 4 . . . cord-005453-4057qib7 9369 1 Patients patient NNS cord-005453-4057qib7 9369 2 colonized colonize VBN cord-005453-4057qib7 9369 3 with with IN cord-005453-4057qib7 9369 4 MDRB MDRB NNP cord-005453-4057qib7 9369 5 are be VBP cord-005453-4057qib7 9369 6 at at IN cord-005453-4057qib7 9369 7 high high JJ cord-005453-4057qib7 9369 8 risk risk NN cord-005453-4057qib7 9369 9 of of IN cord-005453-4057qib7 9369 10 CDI CDI NNP cord-005453-4057qib7 9369 11 . . . cord-005453-4057qib7 9370 1 2 2 LS cord-005453-4057qib7 9370 2 . . . cord-005453-4057qib7 9371 1 High high JJ cord-005453-4057qib7 9371 2 mortality mortality NN cord-005453-4057qib7 9371 3 due due IN cord-005453-4057qib7 9371 4 to to IN cord-005453-4057qib7 9371 5 infections infection NNS cord-005453-4057qib7 9371 6 and/or and/or CC cord-005453-4057qib7 9371 7 GVHD GVHD NNP cord-005453-4057qib7 9371 8 in in IN cord-005453-4057qib7 9371 9 patients patient NNS cord-005453-4057qib7 9371 10 with with IN cord-005453-4057qib7 9371 11 CDI CDI NNP cord-005453-4057qib7 9371 12 . . . cord-005453-4057qib7 9372 1 3 3 LS cord-005453-4057qib7 9372 2 . . . cord-005453-4057qib7 9373 1 Due due IN cord-005453-4057qib7 9373 2 to to TO cord-005453-4057qib7 9373 3 lower lower VB cord-005453-4057qib7 9373 4 efficacy efficacy NN cord-005453-4057qib7 9373 5 and and CC cord-005453-4057qib7 9373 6 harmful harmful JJ cord-005453-4057qib7 9373 7 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 9373 8 impact impact NN cord-005453-4057qib7 9373 9 , , , cord-005453-4057qib7 9373 10 metronidazole metronidazole NNP cord-005453-4057qib7 9373 11 should should MD cord-005453-4057qib7 9373 12 not not RB cord-005453-4057qib7 9373 13 be be VB cord-005453-4057qib7 9373 14 the the DT cord-005453-4057qib7 9373 15 first first JJ cord-005453-4057qib7 9373 16 line line NN cord-005453-4057qib7 9373 17 treatment treatment NN cord-005453-4057qib7 9373 18 in in IN cord-005453-4057qib7 9373 19 CDI CDI NNP cord-005453-4057qib7 9373 20 post post NN cord-005453-4057qib7 9373 21 - - NN cord-005453-4057qib7 9373 22 HCT hct NN cord-005453-4057qib7 9373 23 . . . cord-005453-4057qib7 9374 1 4 4 LS cord-005453-4057qib7 9374 2 . . . cord-005453-4057qib7 9375 1 Emphasis emphasis NN cord-005453-4057qib7 9375 2 must must MD cord-005453-4057qib7 9375 3 be be VB cord-005453-4057qib7 9375 4 put put VBN cord-005453-4057qib7 9375 5 on on IN cord-005453-4057qib7 9375 6 fast fast JJ cord-005453-4057qib7 9375 7 CDI CDI NNP cord-005453-4057qib7 9375 8 resolution resolution NN cord-005453-4057qib7 9375 9 to to TO cord-005453-4057qib7 9375 10 interrupt interrupt VB cord-005453-4057qib7 9375 11 a a DT cord-005453-4057qib7 9375 12 vicious vicious JJ cord-005453-4057qib7 9375 13 circle circle NN cord-005453-4057qib7 9375 14 of of IN cord-005453-4057qib7 9375 15 the the DT cord-005453-4057qib7 9375 16 intestinal intestinal JJ cord-005453-4057qib7 9375 17 inflammatory inflammatory JJ cord-005453-4057qib7 9375 18 processes process NNS cord-005453-4057qib7 9375 19 . . . cord-005453-4057qib7 9376 1 Disclosure disclosure NN cord-005453-4057qib7 9376 2 : : : cord-005453-4057qib7 9376 3 Nothing nothing NN cord-005453-4057qib7 9376 4 to to TO cord-005453-4057qib7 9376 5 declare declare VB cord-005453-4057qib7 9376 6 Establishing establish VBG cord-005453-4057qib7 9376 7 optimal optimal JJ cord-005453-4057qib7 9376 8 preemptive preemptive JJ cord-005453-4057qib7 9376 9 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 9376 10 therapy therapy NN cord-005453-4057qib7 9376 11 threshold threshold NN cord-005453-4057qib7 9376 12 post post NN cord-005453-4057qib7 9376 13 allogeneic allogeneic NN cord-005453-4057qib7 9376 14 HCT hct NN cord-005453-4057qib7 9376 15 in in IN cord-005453-4057qib7 9376 16 a a DT cord-005453-4057qib7 9376 17 patient patient JJ cord-005453-4057qib7 9376 18 population population NN cord-005453-4057qib7 9376 19 with with IN cord-005453-4057qib7 9376 20 high high JJ cord-005453-4057qib7 9376 21 prevalence prevalence NN cord-005453-4057qib7 9376 22 of of IN cord-005453-4057qib7 9376 23 seropositive seropositive JJ cord-005453-4057qib7 9376 24 status status NN cord-005453-4057qib7 9376 25 Background background NN cord-005453-4057qib7 9376 26 : : : cord-005453-4057qib7 9376 27 Preemptive preemptive JJ cord-005453-4057qib7 9376 28 therapy therapy NN cord-005453-4057qib7 9376 29 ( ( -LRB- cord-005453-4057qib7 9376 30 PET PET NNP cord-005453-4057qib7 9376 31 ) ) -RRB- cord-005453-4057qib7 9376 32 for for IN cord-005453-4057qib7 9377 1 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 9377 2 ( ( -LRB- cord-005453-4057qib7 9377 3 CMV CMV NNP cord-005453-4057qib7 9377 4 ) ) -RRB- cord-005453-4057qib7 9377 5 reactivation reactivation NN cord-005453-4057qib7 9377 6 post post NN cord-005453-4057qib7 9378 1 allogeneic allogeneic JJ cord-005453-4057qib7 9378 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 9378 3 stem stem NN cord-005453-4057qib7 9378 4 cell cell NN cord-005453-4057qib7 9378 5 transplantation transplantation NN cord-005453-4057qib7 9378 6 ( ( -LRB- cord-005453-4057qib7 9378 7 HCT HCT NNP cord-005453-4057qib7 9378 8 ) ) -RRB- cord-005453-4057qib7 9378 9 was be VBD cord-005453-4057qib7 9378 10 shown show VBN cord-005453-4057qib7 9378 11 to to TO cord-005453-4057qib7 9378 12 decrease decrease VB cord-005453-4057qib7 9378 13 the the DT cord-005453-4057qib7 9378 14 incidence incidence NN cord-005453-4057qib7 9378 15 of of IN cord-005453-4057qib7 9378 16 CMV CMV NNP cord-005453-4057qib7 9378 17 disease disease NN cord-005453-4057qib7 9378 18 . . . cord-005453-4057qib7 9379 1 However however RB cord-005453-4057qib7 9379 2 , , , cord-005453-4057qib7 9379 3 the the DT cord-005453-4057qib7 9379 4 optimal optimal JJ cord-005453-4057qib7 9379 5 PET pet NN cord-005453-4057qib7 9379 6 threshold threshold NN cord-005453-4057qib7 9379 7 is be VBZ cord-005453-4057qib7 9379 8 unknown unknown JJ cord-005453-4057qib7 9379 9 and and CC cord-005453-4057qib7 9379 10 there there EX cord-005453-4057qib7 9379 11 are be VBP cord-005453-4057qib7 9379 12 significant significant JJ cord-005453-4057qib7 9379 13 toxicities toxicity NNS cord-005453-4057qib7 9379 14 associated associate VBN cord-005453-4057qib7 9379 15 with with IN cord-005453-4057qib7 9379 16 anti anti JJ cord-005453-4057qib7 9379 17 - - JJ cord-005453-4057qib7 9379 18 CMV CMV NNP cord-005453-4057qib7 9379 19 therapy therapy NN cord-005453-4057qib7 9379 20 . . . cord-005453-4057qib7 9380 1 At at IN cord-005453-4057qib7 9380 2 our -PRON- PRP$ cord-005453-4057qib7 9380 3 institution institution NN cord-005453-4057qib7 9380 4 , , , cord-005453-4057qib7 9380 5 we -PRON- PRP cord-005453-4057qib7 9380 6 initiate initiate VBP cord-005453-4057qib7 9380 7 PET pet NN cord-005453-4057qib7 9380 8 at at IN cord-005453-4057qib7 9380 9 CMV CMV NNP cord-005453-4057qib7 9380 10 DNA DNA NNP cord-005453-4057qib7 9380 11 titer titer NN cord-005453-4057qib7 9380 12 above above IN cord-005453-4057qib7 9380 13 1000 1000 CD cord-005453-4057qib7 9380 14 copies copy NNS cord-005453-4057qib7 9380 15 / / SYM cord-005453-4057qib7 9380 16 mL ml NN cord-005453-4057qib7 9380 17 ( ( -LRB- cord-005453-4057qib7 9380 18 1560 1560 CD cord-005453-4057qib7 9380 19 IU IU NNP cord-005453-4057qib7 9380 20 / / SYM cord-005453-4057qib7 9380 21 mL mL NNP cord-005453-4057qib7 9380 22 ) ) -RRB- cord-005453-4057qib7 9380 23 . . . cord-005453-4057qib7 9381 1 Our -PRON- PRP$ cord-005453-4057qib7 9381 2 aim aim NN cord-005453-4057qib7 9381 3 was be VBD cord-005453-4057qib7 9381 4 to to TO cord-005453-4057qib7 9381 5 examine examine VB cord-005453-4057qib7 9381 6 the the DT cord-005453-4057qib7 9381 7 efficacy efficacy NN cord-005453-4057qib7 9381 8 of of IN cord-005453-4057qib7 9381 9 this this DT cord-005453-4057qib7 9381 10 approach approach NN cord-005453-4057qib7 9381 11 including include VBG cord-005453-4057qib7 9381 12 the the DT cord-005453-4057qib7 9381 13 incidence incidence NN cord-005453-4057qib7 9381 14 of of IN cord-005453-4057qib7 9381 15 spontaneous spontaneous JJ cord-005453-4057qib7 9381 16 clearance clearance NN cord-005453-4057qib7 9381 17 in in IN cord-005453-4057qib7 9381 18 a a DT cord-005453-4057qib7 9381 19 population population NN cord-005453-4057qib7 9381 20 with with IN cord-005453-4057qib7 9381 21 high high JJ cord-005453-4057qib7 9381 22 prevalence prevalence NN cord-005453-4057qib7 9381 23 of of IN cord-005453-4057qib7 9381 24 CMV CMV NNP cord-005453-4057qib7 9381 25 seropositive seropositive JJ cord-005453-4057qib7 9381 26 status status NN cord-005453-4057qib7 9381 27 . . . cord-005453-4057qib7 9382 1 Methods method NNS cord-005453-4057qib7 9382 2 : : : cord-005453-4057qib7 9383 1 After after IN cord-005453-4057qib7 9383 2 due due JJ cord-005453-4057qib7 9383 3 IRB IRB NNP cord-005453-4057qib7 9383 4 approval approval NN cord-005453-4057qib7 9383 5 , , , cord-005453-4057qib7 9383 6 patients patient NNS cord-005453-4057qib7 9383 7 that that IN cord-005453-4057qib7 9383 8 underwent undergo VBD cord-005453-4057qib7 9383 9 allogeneic allogeneic NN cord-005453-4057qib7 9383 10 HCT HCT NNP cord-005453-4057qib7 9383 11 were be VBD cord-005453-4057qib7 9383 12 identified identify VBN cord-005453-4057qib7 9383 13 and and CC cord-005453-4057qib7 9383 14 records record NNS cord-005453-4057qib7 9383 15 retrospectively retrospectively RB cord-005453-4057qib7 9383 16 extracted extract VBN cord-005453-4057qib7 9383 17 . . . cord-005453-4057qib7 9384 1 CMV CMV NNP cord-005453-4057qib7 9384 2 reactivation reactivation NN cord-005453-4057qib7 9384 3 was be VBD cord-005453-4057qib7 9384 4 defined define VBN cord-005453-4057qib7 9384 5 as as IN cord-005453-4057qib7 9385 1 the the DT cord-005453-4057qib7 9385 2 first first JJ cord-005453-4057qib7 9385 3 detectable detectable JJ cord-005453-4057qib7 9385 4 viral viral JJ cord-005453-4057qib7 9385 5 titer titer NN cord-005453-4057qib7 9385 6 post post NN cord-005453-4057qib7 9385 7 HCT hct NN cord-005453-4057qib7 9385 8 from from IN cord-005453-4057qib7 9385 9 plasma plasma NN cord-005453-4057qib7 9385 10 samples sample NNS cord-005453-4057qib7 9385 11 whereas whereas IN cord-005453-4057qib7 9385 12 clearance clearance NN cord-005453-4057qib7 9385 13 of of IN cord-005453-4057qib7 9385 14 viremia viremia NN cord-005453-4057qib7 9385 15 as as IN cord-005453-4057qib7 9385 16 the the DT cord-005453-4057qib7 9385 17 first first JJ cord-005453-4057qib7 9385 18 date date NN cord-005453-4057qib7 9385 19 of of IN cord-005453-4057qib7 9385 20 two two CD cord-005453-4057qib7 9385 21 negative negative JJ cord-005453-4057qib7 9385 22 PCR PCR NNP cord-005453-4057qib7 9385 23 values value NNS cord-005453-4057qib7 9385 24 obtained obtain VBN cord-005453-4057qib7 9385 25 at at IN cord-005453-4057qib7 9385 26 least least RBS cord-005453-4057qib7 9385 27 1 1 CD cord-005453-4057qib7 9385 28 week week NN cord-005453-4057qib7 9385 29 apart apart RB cord-005453-4057qib7 9385 30 . . . cord-005453-4057qib7 9386 1 CMV CMV NNP cord-005453-4057qib7 9386 2 monitoring monitoring NN cord-005453-4057qib7 9386 3 was be VBD cord-005453-4057qib7 9386 4 initiated initiate VBN cord-005453-4057qib7 9386 5 post post NN cord-005453-4057qib7 9387 1 HCT HCT NNP cord-005453-4057qib7 9387 2 performed perform VBD cord-005453-4057qib7 9387 3 at at IN cord-005453-4057qib7 9387 4 least least JJS cord-005453-4057qib7 9387 5 weekly weekly RB cord-005453-4057qib7 9387 6 during during IN cord-005453-4057qib7 9387 7 the the DT cord-005453-4057qib7 9387 8 first first JJ cord-005453-4057qib7 9387 9 100 100 CD cord-005453-4057qib7 9387 10 days day NNS cord-005453-4057qib7 9387 11 and and CC cord-005453-4057qib7 9387 12 every every DT cord-005453-4057qib7 9387 13 2 2 CD cord-005453-4057qib7 9387 14 - - SYM cord-005453-4057qib7 9387 15 4 4 CD cord-005453-4057qib7 9387 16 weeks week NNS cord-005453-4057qib7 9387 17 thereafter thereafter RB cord-005453-4057qib7 9387 18 . . . cord-005453-4057qib7 9388 1 A a DT cord-005453-4057qib7 9388 2 high high JJ cord-005453-4057qib7 9388 3 sensitivity sensitivity NN cord-005453-4057qib7 9388 4 assay assay NN cord-005453-4057qib7 9388 5 Abbott Abbott NNP cord-005453-4057qib7 9388 6 RealTime RealTime NNP cord-005453-4057qib7 9388 7 CMV CMV NNP cord-005453-4057qib7 9388 8 was be VBD cord-005453-4057qib7 9388 9 used use VBN cord-005453-4057qib7 9388 10 with with IN cord-005453-4057qib7 9388 11 detection detection NN cord-005453-4057qib7 9388 12 threshold threshold NN cord-005453-4057qib7 9388 13 of of IN cord-005453-4057qib7 9388 14 20 20 CD cord-005453-4057qib7 9388 15 copies copy NNS cord-005453-4057qib7 9388 16 / / SYM cord-005453-4057qib7 9388 17 mL ml NN cord-005453-4057qib7 9388 18 ( ( -LRB- cord-005453-4057qib7 9388 19 31.2 31.2 CD cord-005453-4057qib7 9388 20 IU IU NNP cord-005453-4057qib7 9388 21 / / SYM cord-005453-4057qib7 9388 22 mL mL NNP cord-005453-4057qib7 9388 23 ) ) -RRB- cord-005453-4057qib7 9388 24 . . . cord-005453-4057qib7 9389 1 Analysis analysis NN cord-005453-4057qib7 9389 2 was be VBD cord-005453-4057qib7 9389 3 computed compute VBN cord-005453-4057qib7 9389 4 using use VBG cord-005453-4057qib7 9389 5 JMP JMP NNP cord-005453-4057qib7 9389 6 v. v. CC cord-005453-4057qib7 9389 7 14.0.1 14.0.1 CD cord-005453-4057qib7 9389 8 Results result NNS cord-005453-4057qib7 9389 9 : : : cord-005453-4057qib7 9389 10 A. A. NNP cord-005453-4057qib7 9389 11 Baseline baseline JJ cord-005453-4057qib7 9389 12 characteristics characteristic NNS cord-005453-4057qib7 9389 13 : : : cord-005453-4057qib7 9389 14 A a DT cord-005453-4057qib7 9389 15 total total NN cord-005453-4057qib7 9389 16 of of IN cord-005453-4057qib7 9389 17 195 195 CD cord-005453-4057qib7 9389 18 patients patient NNS cord-005453-4057qib7 9389 19 were be VBD cord-005453-4057qib7 9389 20 identified identify VBN cord-005453-4057qib7 9389 21 and and CC cord-005453-4057qib7 9389 22 included include VBN cord-005453-4057qib7 9389 23 with with IN cord-005453-4057qib7 9389 24 a a DT cord-005453-4057qib7 9389 25 median median NN cord-005453-4057qib7 9389 26 follow follow NN cord-005453-4057qib7 9389 27 up up IN cord-005453-4057qib7 9389 28 of of IN cord-005453-4057qib7 9389 29 18.1 18.1 CD cord-005453-4057qib7 9389 30 ( ( -LRB- cord-005453-4057qib7 9389 31 0.7 0.7 CD cord-005453-4057qib7 9389 32 - - HYPH cord-005453-4057qib7 9389 33 95.6 95.6 CD cord-005453-4057qib7 9389 34 ) ) -RRB- cord-005453-4057qib7 9389 35 months month NNS cord-005453-4057qib7 9389 36 . . . cord-005453-4057qib7 9390 1 Median median JJ cord-005453-4057qib7 9390 2 age age NN cord-005453-4057qib7 9390 3 was be VBD cord-005453-4057qib7 9390 4 26 26 CD cord-005453-4057qib7 9390 5 ( ( -LRB- cord-005453-4057qib7 9390 6 14 14 CD cord-005453-4057qib7 9390 7 - - SYM cord-005453-4057qib7 9390 8 63 63 CD cord-005453-4057qib7 9390 9 ) ) -RRB- cord-005453-4057qib7 9390 10 years year NNS cord-005453-4057qib7 9390 11 and and CC cord-005453-4057qib7 9390 12 58 58 CD cord-005453-4057qib7 9390 13 % % NN cord-005453-4057qib7 9390 14 were be VBD cord-005453-4057qib7 9390 15 male male JJ cord-005453-4057qib7 9390 16 . . . cord-005453-4057qib7 9391 1 Indication indication NN cord-005453-4057qib7 9391 2 for for IN cord-005453-4057qib7 9391 3 HCT HCT NNP cord-005453-4057qib7 9391 4 was be VBD cord-005453-4057qib7 9391 5 for for IN cord-005453-4057qib7 9391 6 a a DT cord-005453-4057qib7 9391 7 malignant malignant JJ cord-005453-4057qib7 9391 8 disorder disorder NN cord-005453-4057qib7 9391 9 in in IN cord-005453-4057qib7 9391 10 77 77 CD cord-005453-4057qib7 9391 11 % % NN cord-005453-4057qib7 9391 12 of of IN cord-005453-4057qib7 9391 13 cases case NNS cord-005453-4057qib7 9391 14 . . . cord-005453-4057qib7 9392 1 The the DT cord-005453-4057qib7 9392 2 majority majority NN cord-005453-4057qib7 9392 3 had have VBD cord-005453-4057qib7 9392 4 a a DT cord-005453-4057qib7 9392 5 matched match VBN cord-005453-4057qib7 9392 6 related related JJ cord-005453-4057qib7 9392 7 donor donor NN cord-005453-4057qib7 9392 8 ( ( -LRB- cord-005453-4057qib7 9392 9 87 87 CD cord-005453-4057qib7 9392 10 % % NN cord-005453-4057qib7 9392 11 ) ) -RRB- cord-005453-4057qib7 9392 12 and and CC cord-005453-4057qib7 9392 13 CMV CMV NNP cord-005453-4057qib7 9392 14 IgG igg NN cord-005453-4057qib7 9392 15 was be VBD cord-005453-4057qib7 9392 16 positive positive JJ cord-005453-4057qib7 9392 17 in in IN cord-005453-4057qib7 9392 18 both both DT cord-005453-4057qib7 9392 19 donor donor NN cord-005453-4057qib7 9392 20 and and CC cord-005453-4057qib7 9392 21 recipient recipient NN cord-005453-4057qib7 9392 22 in in IN cord-005453-4057qib7 9392 23 98 98 CD cord-005453-4057qib7 9392 24 % % NN cord-005453-4057qib7 9392 25 of of IN cord-005453-4057qib7 9392 26 cases case NNS cord-005453-4057qib7 9392 27 . . . cord-005453-4057qib7 9393 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 9393 2 conditioning conditioning NN cord-005453-4057qib7 9393 3 was be VBD cord-005453-4057qib7 9393 4 given give VBN cord-005453-4057qib7 9393 5 to to IN cord-005453-4057qib7 9393 6 117 117 CD cord-005453-4057qib7 9393 7 ( ( -LRB- cord-005453-4057qib7 9393 8 60 60 CD cord-005453-4057qib7 9393 9 % % NN cord-005453-4057qib7 9393 10 ) ) -RRB- cord-005453-4057qib7 9393 11 and and CC cord-005453-4057qib7 9393 12 109 109 CD cord-005453-4057qib7 9393 13 ( ( -LRB- cord-005453-4057qib7 9393 14 56 56 CD cord-005453-4057qib7 9393 15 % % NN cord-005453-4057qib7 9393 16 ) ) -RRB- cord-005453-4057qib7 9393 17 received receive VBD cord-005453-4057qib7 9393 18 TBI TBI NNP cord-005453-4057qib7 9393 19 . . . cord-005453-4057qib7 9394 1 In in IN cord-005453-4057qib7 9394 2 vivo vivo NNP cord-005453-4057qib7 9394 3 T t NN cord-005453-4057qib7 9394 4 - - HYPH cord-005453-4057qib7 9394 5 cell cell NN cord-005453-4057qib7 9394 6 depletion depletion NN cord-005453-4057qib7 9394 7 was be VBD cord-005453-4057qib7 9394 8 given give VBN cord-005453-4057qib7 9394 9 to to IN cord-005453-4057qib7 9394 10 76 76 CD cord-005453-4057qib7 9394 11 ( ( -LRB- cord-005453-4057qib7 9394 12 39 39 CD cord-005453-4057qib7 9394 13 % % NN cord-005453-4057qib7 9394 14 ) ) -RRB- cord-005453-4057qib7 9394 15 ; ; : cord-005453-4057qib7 9394 16 ATG ATG NNP cord-005453-4057qib7 9394 17 in in IN cord-005453-4057qib7 9394 18 39 39 CD cord-005453-4057qib7 9394 19 ( ( -LRB- cord-005453-4057qib7 9394 20 20 20 CD cord-005453-4057qib7 9394 21 % % NN cord-005453-4057qib7 9394 22 ) ) -RRB- cord-005453-4057qib7 9394 23 and and CC cord-005453-4057qib7 9394 24 alemtuzumab alemtuzumab VBN cord-005453-4057qib7 9394 25 in in IN cord-005453-4057qib7 9394 26 37 37 CD cord-005453-4057qib7 9394 27 ( ( -LRB- cord-005453-4057qib7 9394 28 19 19 CD cord-005453-4057qib7 9394 29 % % NN cord-005453-4057qib7 9394 30 ) ) -RRB- cord-005453-4057qib7 9394 31 . . . cord-005453-4057qib7 9395 1 B. B. NNP cord-005453-4057qib7 9395 2 CMV CMV NNP cord-005453-4057qib7 9395 3 Reactivation Reactivation NNP cord-005453-4057qib7 9395 4 and and CC cord-005453-4057qib7 9395 5 PET pet NN cord-005453-4057qib7 9395 6 : : : cord-005453-4057qib7 9395 7 A a DT cord-005453-4057qib7 9395 8 total total NN cord-005453-4057qib7 9395 9 of of IN cord-005453-4057qib7 9395 10 178 178 CD cord-005453-4057qib7 9395 11 ( ( -LRB- cord-005453-4057qib7 9395 12 91 91 CD cord-005453-4057qib7 9395 13 % % NN cord-005453-4057qib7 9395 14 ) ) -RRB- cord-005453-4057qib7 9395 15 patients patient NNS cord-005453-4057qib7 9395 16 had have VBD cord-005453-4057qib7 9395 17 a a DT cord-005453-4057qib7 9395 18 positive positive JJ cord-005453-4057qib7 9395 19 CMV CMV NNP cord-005453-4057qib7 9395 20 PCR PCR NNP cord-005453-4057qib7 9395 21 with with IN cord-005453-4057qib7 9395 22 median median JJ cord-005453-4057qib7 9395 23 days day NNS cord-005453-4057qib7 9395 24 to to IN cord-005453-4057qib7 9395 25 reactivation reactivation NN cord-005453-4057qib7 9395 26 post post NN cord-005453-4057qib7 9395 27 HCT hct NN cord-005453-4057qib7 9395 28 of of IN cord-005453-4057qib7 9395 29 17 17 CD cord-005453-4057qib7 9395 30 ; ; : cord-005453-4057qib7 9395 31 129 129 CD cord-005453-4057qib7 9395 32 ( ( -LRB- cord-005453-4057qib7 9395 33 66 66 CD cord-005453-4057qib7 9395 34 % % NN cord-005453-4057qib7 9395 35 ) ) -RRB- cord-005453-4057qib7 9395 36 patients patient NNS cord-005453-4057qib7 9395 37 had have VBD cord-005453-4057qib7 9395 38 peak peak NN cord-005453-4057qib7 9395 39 CMV CMV NNP cord-005453-4057qib7 9396 1 titer titer NN cord-005453-4057qib7 9396 2 < < XX cord-005453-4057qib7 9396 3 1000 1000 CD cord-005453-4057qib7 9396 4 copies copy NNS cord-005453-4057qib7 9396 5 / / SYM cord-005453-4057qib7 9396 6 mL ml NN cord-005453-4057qib7 9396 7 ( ( -LRB- cord-005453-4057qib7 9396 8 low low JJ cord-005453-4057qib7 9396 9 titer titer NN cord-005453-4057qib7 9396 10 ) ) -RRB- cord-005453-4057qib7 9397 1 whereas whereas IN cord-005453-4057qib7 9397 2 the the DT cord-005453-4057qib7 9397 3 remaining remain VBG cord-005453-4057qib7 9397 4 49 49 CD cord-005453-4057qib7 9397 5 ( ( -LRB- cord-005453-4057qib7 9397 6 25 25 CD cord-005453-4057qib7 9397 7 % % NN cord-005453-4057qib7 9397 8 ) ) -RRB- cord-005453-4057qib7 9397 9 had have VBD cord-005453-4057qib7 9397 10 a a DT cord-005453-4057qib7 9397 11 peak peak NN cord-005453-4057qib7 9397 12 titer titer NN cord-005453-4057qib7 9397 13 ≥ ≥ CD cord-005453-4057qib7 9397 14 1000 1000 CD cord-005453-4057qib7 9397 15 copies copy NNS cord-005453-4057qib7 9397 16 / / SYM cord-005453-4057qib7 9397 17 mL ml NN cord-005453-4057qib7 9397 18 ( ( -LRB- cord-005453-4057qib7 9397 19 high high JJ cord-005453-4057qib7 9397 20 titer titer NN cord-005453-4057qib7 9397 21 ) ) -RRB- cord-005453-4057qib7 9397 22 . . . cord-005453-4057qib7 9398 1 Patients patient NNS cord-005453-4057qib7 9398 2 with with IN cord-005453-4057qib7 9398 3 high high JJ cord-005453-4057qib7 9398 4 titer titer NN cord-005453-4057qib7 9398 5 were be VBD cord-005453-4057qib7 9398 6 more more RBR cord-005453-4057qib7 9398 7 likely likely JJ cord-005453-4057qib7 9398 8 to to TO cord-005453-4057qib7 9398 9 be be VB cord-005453-4057qib7 9398 10 older old JJR cord-005453-4057qib7 9398 11 ( ( -LRB- cord-005453-4057qib7 9398 12 p p NN cord-005453-4057qib7 9398 13 = = SYM cord-005453-4057qib7 9398 14 0.019 0.019 CD cord-005453-4057qib7 9398 15 ) ) -RRB- cord-005453-4057qib7 9398 16 , , , cord-005453-4057qib7 9398 17 have have VBP cord-005453-4057qib7 9398 18 malignant malignant JJ cord-005453-4057qib7 9398 19 disease disease NN cord-005453-4057qib7 9398 20 ( ( -LRB- cord-005453-4057qib7 9398 21 p p NN cord-005453-4057qib7 9398 22 = = SYM cord-005453-4057qib7 9398 23 0.019 0.019 CD cord-005453-4057qib7 9398 24 ) ) -RRB- cord-005453-4057qib7 9398 25 , , , cord-005453-4057qib7 9398 26 haploidentical haploidentical JJ cord-005453-4057qib7 9398 27 or or CC cord-005453-4057qib7 9398 28 unrelated unrelated JJ cord-005453-4057qib7 9398 29 donor donor NN cord-005453-4057qib7 9398 30 ( ( -LRB- cord-005453-4057qib7 9398 31 p p NN cord-005453-4057qib7 9398 32 < < XX cord-005453-4057qib7 9398 33 0.0001 0.0001 CD cord-005453-4057qib7 9398 34 ) ) -RRB- cord-005453-4057qib7 9398 35 and and CC cord-005453-4057qib7 9398 36 higher high JJR cord-005453-4057qib7 9398 37 incidence incidence NN cord-005453-4057qib7 9398 38 of of IN cord-005453-4057qib7 9398 39 aGvHD agvhd NN cord-005453-4057qib7 9398 40 grade grade NN cord-005453-4057qib7 9398 41 II II NNP cord-005453-4057qib7 9398 42 - - HYPH cord-005453-4057qib7 9398 43 IV IV NNP cord-005453-4057qib7 9398 44 ( ( -LRB- cord-005453-4057qib7 9398 45 P p NN cord-005453-4057qib7 9398 46 = = SYM cord-005453-4057qib7 9398 47 0.003 0.003 CD cord-005453-4057qib7 9398 48 ) ) -RRB- cord-005453-4057qib7 9398 49 as as IN cord-005453-4057qib7 9398 50 shown show VBN cord-005453-4057qib7 9398 51 in in IN cord-005453-4057qib7 9398 52 the the DT cord-005453-4057qib7 9398 53 table table NN cord-005453-4057qib7 9398 54 . . . cord-005453-4057qib7 9399 1 Median median JJ cord-005453-4057qib7 9399 2 peak peak NN cord-005453-4057qib7 9399 3 titers titer NNS cord-005453-4057qib7 9399 4 for for IN cord-005453-4057qib7 9399 5 the the DT cord-005453-4057qib7 9399 6 low low JJ cord-005453-4057qib7 9399 7 and and CC cord-005453-4057qib7 9399 8 high high JJ cord-005453-4057qib7 9399 9 groups group NNS cord-005453-4057qib7 9399 10 were be VBD cord-005453-4057qib7 9399 11 111 111 CD cord-005453-4057qib7 9399 12 vs. vs. IN cord-005453-4057qib7 9399 13 4638 4638 CD cord-005453-4057qib7 9399 14 , , , cord-005453-4057qib7 9399 15 respectively respectively RB cord-005453-4057qib7 9399 16 ( ( -LRB- cord-005453-4057qib7 9399 17 p p NN cord-005453-4057qib7 9399 18 < < XX cord-005453-4057qib7 9399 19 0.0001).120 0.0001).120 NNP cord-005453-4057qib7 9399 20 ( ( -LRB- cord-005453-4057qib7 9399 21 93 93 CD cord-005453-4057qib7 9399 22 % % NN cord-005453-4057qib7 9399 23 ) ) -RRB- cord-005453-4057qib7 9399 24 patients patient NNS cord-005453-4057qib7 9399 25 with with IN cord-005453-4057qib7 9399 26 low low JJ cord-005453-4057qib7 9399 27 titers titer NNS cord-005453-4057qib7 9399 28 cleared clear VBD cord-005453-4057qib7 9399 29 spontaneously spontaneously RB cord-005453-4057qib7 9399 30 with with IN cord-005453-4057qib7 9399 31 median median JJ cord-005453-4057qib7 9399 32 time time NN cord-005453-4057qib7 9399 33 to to IN cord-005453-4057qib7 9399 34 clearance clearance NN cord-005453-4057qib7 9399 35 of of IN cord-005453-4057qib7 9399 36 40 40 CD cord-005453-4057qib7 9399 37 days day NNS cord-005453-4057qib7 9399 38 ( ( -LRB- cord-005453-4057qib7 9399 39 4 4 CD cord-005453-4057qib7 9399 40 - - SYM cord-005453-4057qib7 9399 41 188 188 CD cord-005453-4057qib7 9399 42 ) ) -RRB- cord-005453-4057qib7 9399 43 , , , cord-005453-4057qib7 9399 44 1 1 CD cord-005453-4057qib7 9399 45 ( ( -LRB- cord-005453-4057qib7 9399 46 1 1 CD cord-005453-4057qib7 9399 47 % % NN cord-005453-4057qib7 9399 48 ) ) -RRB- cord-005453-4057qib7 9399 49 received receive VBD cord-005453-4057qib7 9399 50 anti anti JJ cord-005453-4057qib7 9399 51 CMV CMV NNP cord-005453-4057qib7 9399 52 therapy therapy NN cord-005453-4057qib7 9399 53 and and CC cord-005453-4057qib7 9399 54 the the DT cord-005453-4057qib7 9399 55 remaining remain VBG cord-005453-4057qib7 9399 56 died die VBD cord-005453-4057qib7 9399 57 with with IN cord-005453-4057qib7 9399 58 active active JJ cord-005453-4057qib7 9399 59 viremia viremia NN cord-005453-4057qib7 9399 60 ( ( -LRB- cord-005453-4057qib7 9400 1 range range VBP cord-005453-4057qib7 9400 2 49 49 CD cord-005453-4057qib7 9400 3 - - SYM cord-005453-4057qib7 9400 4 561 561 CD cord-005453-4057qib7 9400 5 copies copy NNS cord-005453-4057qib7 9400 6 /mL /mL . cord-005453-4057qib7 9400 7 ) ) -RRB- cord-005453-4057qib7 9400 8 with with IN cord-005453-4057qib7 9400 9 active active JJ cord-005453-4057qib7 9400 10 disease disease NN cord-005453-4057qib7 9400 11 . . . cord-005453-4057qib7 9401 1 One one CD cord-005453-4057qib7 9401 2 patient patient NN cord-005453-4057qib7 9401 3 in in IN cord-005453-4057qib7 9401 4 the the DT cord-005453-4057qib7 9401 5 high high JJ cord-005453-4057qib7 9401 6 titer titer NN cord-005453-4057qib7 9401 7 group group NN cord-005453-4057qib7 9401 8 developed develop VBD cord-005453-4057qib7 9401 9 CMV CMV NNP cord-005453-4057qib7 9401 10 disease disease NN cord-005453-4057qib7 9401 11 . . . cord-005453-4057qib7 9402 1 2-year 2-year CD cord-005453-4057qib7 9402 2 OS OS NNP cord-005453-4057qib7 9402 3 and and CC cord-005453-4057qib7 9402 4 CI CI NNP cord-005453-4057qib7 9402 5 - - HYPH cord-005453-4057qib7 9402 6 NRM NRM NNP cord-005453-4057qib7 9402 7 was be VBD cord-005453-4057qib7 9402 8 67.9 67.9 CD cord-005453-4057qib7 9402 9 % % NN cord-005453-4057qib7 9402 10 vs. vs. CC cord-005453-4057qib7 9402 11 55.4 55.4 CD cord-005453-4057qib7 9402 12 % % NN cord-005453-4057qib7 9402 13 ( ( -LRB- cord-005453-4057qib7 9402 14 p p NN cord-005453-4057qib7 9402 15 = = SYM cord-005453-4057qib7 9402 16 0.1 0.1 CD cord-005453-4057qib7 9402 17 ) ) -RRB- cord-005453-4057qib7 9402 18 and and CC cord-005453-4057qib7 9402 19 8 8 CD cord-005453-4057qib7 9402 20 % % NN cord-005453-4057qib7 9402 21 vs. vs. IN cord-005453-4057qib7 9402 22 19.1 19.1 CD cord-005453-4057qib7 9402 23 % % NN cord-005453-4057qib7 9402 24 ( ( -LRB- cord-005453-4057qib7 9402 25 p p NN cord-005453-4057qib7 9402 26 = = SYM cord-005453-4057qib7 9402 27 0.034 0.034 CD cord-005453-4057qib7 9402 28 ) ) -RRB- cord-005453-4057qib7 9402 29 in in IN cord-005453-4057qib7 9402 30 the the DT cord-005453-4057qib7 9402 31 low low JJ cord-005453-4057qib7 9402 32 and and CC cord-005453-4057qib7 9402 33 high high JJ cord-005453-4057qib7 9402 34 titer titer NN cord-005453-4057qib7 9402 35 groups group NNS cord-005453-4057qib7 9402 36 , , , cord-005453-4057qib7 9402 37 respectively respectively RB cord-005453-4057qib7 9402 38 . . . cord-005453-4057qib7 9403 1 Conclusions conclusion NNS cord-005453-4057qib7 9403 2 : : : cord-005453-4057qib7 9404 1 CMV CMV NNP cord-005453-4057qib7 9404 2 reactivation reactivation NN cord-005453-4057qib7 9404 3 was be VBD cord-005453-4057qib7 9404 4 high high JJ cord-005453-4057qib7 9404 5 in in IN cord-005453-4057qib7 9404 6 this this DT cord-005453-4057qib7 9404 7 cohort cohort NN cord-005453-4057qib7 9404 8 however however RB cord-005453-4057qib7 9404 9 of of IN cord-005453-4057qib7 9404 10 low low JJ cord-005453-4057qib7 9404 11 titer titer NN cord-005453-4057qib7 9404 12 viremia viremia NN cord-005453-4057qib7 9404 13 in in IN cord-005453-4057qib7 9404 14 over over IN cord-005453-4057qib7 9404 15 70 70 CD cord-005453-4057qib7 9404 16 % % NN cord-005453-4057qib7 9404 17 . . . cord-005453-4057qib7 9405 1 A a DT cord-005453-4057qib7 9405 2 PET pet NN cord-005453-4057qib7 9405 3 threshold threshold NN cord-005453-4057qib7 9405 4 of of IN cord-005453-4057qib7 9405 5 1000 1000 CD cord-005453-4057qib7 9405 6 copies copy NNS cord-005453-4057qib7 9405 7 / / SYM cord-005453-4057qib7 9405 8 mL ml NN cord-005453-4057qib7 9405 9 ( ( -LRB- cord-005453-4057qib7 9405 10 1560 1560 CD cord-005453-4057qib7 9405 11 IU IU NNP cord-005453-4057qib7 9405 12 / / SYM cord-005453-4057qib7 9405 13 mL mL NNP cord-005453-4057qib7 9405 14 ) ) -RRB- cord-005453-4057qib7 9405 15 appears appear VBZ cord-005453-4057qib7 9405 16 desirable desirable JJ cord-005453-4057qib7 9405 17 as as IN cord-005453-4057qib7 9405 18 it -PRON- PRP cord-005453-4057qib7 9405 19 was be VBD cord-005453-4057qib7 9405 20 associated associate VBN cord-005453-4057qib7 9405 21 with with IN cord-005453-4057qib7 9405 22 spontaneous spontaneous JJ cord-005453-4057qib7 9405 23 clearance clearance NN cord-005453-4057qib7 9405 24 in in IN cord-005453-4057qib7 9405 25 almost almost RB cord-005453-4057qib7 9405 26 all all DT cord-005453-4057qib7 9405 27 patients patient NNS cord-005453-4057qib7 9405 28 while while IN cord-005453-4057qib7 9405 29 minimizing minimize VBG cord-005453-4057qib7 9405 30 treatment treatment NN cord-005453-4057qib7 9405 31 related relate VBN cord-005453-4057qib7 9405 32 toxicity toxicity NN cord-005453-4057qib7 9405 33 . . . cord-005453-4057qib7 9406 1 Validation validation NN cord-005453-4057qib7 9406 2 of of IN cord-005453-4057qib7 9406 3 these these DT cord-005453-4057qib7 9406 4 observations observation NNS cord-005453-4057qib7 9406 5 is be VBZ cord-005453-4057qib7 9406 6 warranted warrant VBN cord-005453-4057qib7 9406 7 . . . cord-005453-4057qib7 9407 1 Background background NN cord-005453-4057qib7 9407 2 : : : cord-005453-4057qib7 9408 1 The the DT cord-005453-4057qib7 9408 2 risk risk NN cord-005453-4057qib7 9408 3 of of IN cord-005453-4057qib7 9408 4 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9408 5 pneumonia pneumonia NN cord-005453-4057qib7 9408 6 often often RB cord-005453-4057qib7 9408 7 warrants warrant VBZ cord-005453-4057qib7 9408 8 antifungal antifungal JJ cord-005453-4057qib7 9408 9 prophylaxis prophylaxis NN cord-005453-4057qib7 9408 10 for for IN cord-005453-4057qib7 9408 11 recipients recipient NNS cord-005453-4057qib7 9408 12 of of IN cord-005453-4057qib7 9408 13 blood blood NN cord-005453-4057qib7 9408 14 and and CC cord-005453-4057qib7 9408 15 marrow marrow NN cord-005453-4057qib7 9408 16 or or CC cord-005453-4057qib7 9408 17 solid solid JJ cord-005453-4057qib7 9408 18 organ organ NN cord-005453-4057qib7 9408 19 transplantation transplantation NN cord-005453-4057qib7 9408 20 . . . cord-005453-4057qib7 9409 1 However however RB cord-005453-4057qib7 9409 2 , , , cord-005453-4057qib7 9409 3 complications complication NNS cord-005453-4057qib7 9409 4 such such JJ cord-005453-4057qib7 9409 5 as as IN cord-005453-4057qib7 9409 6 myelosuppression myelosuppression NNP cord-005453-4057qib7 9409 7 , , , cord-005453-4057qib7 9409 8 nephrotoxicity nephrotoxicity NNP cord-005453-4057qib7 9409 9 , , , cord-005453-4057qib7 9409 10 and and CC cord-005453-4057qib7 9409 11 intolerance intolerance NN cord-005453-4057qib7 9409 12 with with IN cord-005453-4057qib7 9409 13 the the DT cord-005453-4057qib7 9409 14 existing exist VBG cord-005453-4057qib7 9409 15 standard standard NN cord-005453-4057qib7 9409 16 , , , cord-005453-4057qib7 9409 17 trimethoprim trimethoprim NNP cord-005453-4057qib7 9409 18 / / SYM cord-005453-4057qib7 9409 19 sulfamethoxazole sulfamethoxazole NNP cord-005453-4057qib7 9409 20 ( ( -LRB- cord-005453-4057qib7 9409 21 TMP TMP NNP cord-005453-4057qib7 9409 22 / / SYM cord-005453-4057qib7 9409 23 SMX SMX NNP cord-005453-4057qib7 9409 24 ) ) -RRB- cord-005453-4057qib7 9409 25 , , , cord-005453-4057qib7 9409 26 may may MD cord-005453-4057qib7 9409 27 hinder hinder VB cord-005453-4057qib7 9409 28 or or CC cord-005453-4057qib7 9409 29 interrupt interrupt VB cord-005453-4057qib7 9409 30 prophylaxis prophylaxis NN cord-005453-4057qib7 9409 31 . . . cord-005453-4057qib7 9410 1 Rezafungin Rezafungin NNP cord-005453-4057qib7 9410 2 ( ( -LRB- cord-005453-4057qib7 9410 3 RZF RZF NNP cord-005453-4057qib7 9410 4 ) ) -RRB- cord-005453-4057qib7 9410 5 is be VBZ cord-005453-4057qib7 9410 6 a a DT cord-005453-4057qib7 9410 7 novel novel JJ cord-005453-4057qib7 9410 8 echinocandin echinocandin NNS cord-005453-4057qib7 9410 9 in in IN cord-005453-4057qib7 9410 10 development development NN cord-005453-4057qib7 9410 11 for for IN cord-005453-4057qib7 9410 12 prevention prevention NN cord-005453-4057qib7 9410 13 of of IN cord-005453-4057qib7 9410 14 invasive invasive JJ cord-005453-4057qib7 9410 15 fungal fungal NN cord-005453-4057qib7 9410 16 disease disease NN cord-005453-4057qib7 9410 17 caused cause VBN cord-005453-4057qib7 9410 18 by by IN cord-005453-4057qib7 9410 19 Candida Candida NNP cord-005453-4057qib7 9410 20 , , , cord-005453-4057qib7 9410 21 Aspergillus Aspergillus NNP cord-005453-4057qib7 9410 22 , , , cord-005453-4057qib7 9410 23 and and CC cord-005453-4057qib7 9410 24 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9410 25 species specie NNS cord-005453-4057qib7 9410 26 in in IN cord-005453-4057qib7 9410 27 blood blood NN cord-005453-4057qib7 9410 28 and and CC cord-005453-4057qib7 9410 29 marrow marrow NN cord-005453-4057qib7 9410 30 transplant transplant NN cord-005453-4057qib7 9410 31 patients patient NNS cord-005453-4057qib7 9410 32 . . . cord-005453-4057qib7 9411 1 RZF RZF NNP cord-005453-4057qib7 9411 2 has have VBZ cord-005453-4057qib7 9411 3 a a DT cord-005453-4057qib7 9411 4 favorable favorable JJ cord-005453-4057qib7 9411 5 safety safety NN cord-005453-4057qib7 9411 6 and and CC cord-005453-4057qib7 9411 7 tolerability tolerability NN cord-005453-4057qib7 9411 8 profile profile NN cord-005453-4057qib7 9411 9 and and CC cord-005453-4057qib7 9411 10 a a DT cord-005453-4057qib7 9411 11 low low JJ cord-005453-4057qib7 9411 12 risk risk NN cord-005453-4057qib7 9411 13 of of IN cord-005453-4057qib7 9411 14 drug drug NN cord-005453-4057qib7 9411 15 - - HYPH cord-005453-4057qib7 9411 16 drug drug NN cord-005453-4057qib7 9411 17 interactions interaction NNS cord-005453-4057qib7 9411 18 . . . cord-005453-4057qib7 9412 1 Furthermore furthermore RB cord-005453-4057qib7 9412 2 , , , cord-005453-4057qib7 9412 3 the the DT cord-005453-4057qib7 9412 4 stability stability NN cord-005453-4057qib7 9412 5 and and CC cord-005453-4057qib7 9412 6 pharmacokinetics pharmacokinetic NNS cord-005453-4057qib7 9412 7 of of IN cord-005453-4057qib7 9412 8 RZF RZF NNP cord-005453-4057qib7 9412 9 allow allow VBP cord-005453-4057qib7 9412 10 for for IN cord-005453-4057qib7 9412 11 once once RB cord-005453-4057qib7 9412 12 - - HYPH cord-005453-4057qib7 9412 13 weekly weekly NN cord-005453-4057qib7 9412 14 dosing dosing NN cord-005453-4057qib7 9412 15 and and CC cord-005453-4057qib7 9412 16 broad broad JJ cord-005453-4057qib7 9412 17 distribution distribution NN cord-005453-4057qib7 9412 18 to to IN cord-005453-4057qib7 9412 19 the the DT cord-005453-4057qib7 9412 20 lung lung NN cord-005453-4057qib7 9412 21 and and CC cord-005453-4057qib7 9412 22 other other JJ cord-005453-4057qib7 9412 23 target target NN cord-005453-4057qib7 9412 24 organs organ NNS cord-005453-4057qib7 9412 25 . . . cord-005453-4057qib7 9413 1 RZF RZF NNP cord-005453-4057qib7 9413 2 was be VBD cord-005453-4057qib7 9413 3 shown show VBN cord-005453-4057qib7 9413 4 to to TO cord-005453-4057qib7 9413 5 prevent prevent VB cord-005453-4057qib7 9413 6 in in IN cord-005453-4057qib7 9413 7 vitro vitro FW cord-005453-4057qib7 9413 8 Pneumocystis pneumocystis NN cord-005453-4057qib7 9413 9 biofilm biofilm NN cord-005453-4057qib7 9413 10 formation formation NN cord-005453-4057qib7 9413 11 and and CC cord-005453-4057qib7 9413 12 to to TO cord-005453-4057qib7 9413 13 reduce reduce VB cord-005453-4057qib7 9413 14 the the DT cord-005453-4057qib7 9413 15 viability viability NN cord-005453-4057qib7 9413 16 of of IN cord-005453-4057qib7 9413 17 mature mature JJ cord-005453-4057qib7 9413 18 biofilms biofilm NNS cord-005453-4057qib7 9413 19 . . . cord-005453-4057qib7 9414 1 A a DT cord-005453-4057qib7 9414 2 previous previous JJ cord-005453-4057qib7 9414 3 prophylactic prophylactic JJ cord-005453-4057qib7 9414 4 study study NN cord-005453-4057qib7 9414 5 was be VBD cord-005453-4057qib7 9414 6 conducted conduct VBN cord-005453-4057qib7 9414 7 using use VBG cord-005453-4057qib7 9414 8 a a DT cord-005453-4057qib7 9414 9 broader broad JJR cord-005453-4057qib7 9414 10 range range NN cord-005453-4057qib7 9414 11 of of IN cord-005453-4057qib7 9414 12 RZF RZF NNP cord-005453-4057qib7 9414 13 doses dose NNS cord-005453-4057qib7 9414 14 . . . cord-005453-4057qib7 9415 1 In in IN cord-005453-4057qib7 9415 2 the the DT cord-005453-4057qib7 9415 3 current current JJ cord-005453-4057qib7 9415 4 study study NN cord-005453-4057qib7 9415 5 , , , cord-005453-4057qib7 9415 6 the the DT cord-005453-4057qib7 9415 7 efficacy efficacy NN cord-005453-4057qib7 9415 8 of of IN cord-005453-4057qib7 9415 9 RZF RZF NNP cord-005453-4057qib7 9415 10 was be VBD cord-005453-4057qib7 9415 11 evaluated evaluate VBN cord-005453-4057qib7 9415 12 to to TO cord-005453-4057qib7 9415 13 better well RBR cord-005453-4057qib7 9415 14 understand understand VB cord-005453-4057qib7 9415 15 the the DT cord-005453-4057qib7 9415 16 minimum minimum JJ cord-005453-4057qib7 9415 17 doses dose NNS cord-005453-4057qib7 9415 18 necessary necessary JJ cord-005453-4057qib7 9415 19 to to TO cord-005453-4057qib7 9415 20 prevent prevent VB cord-005453-4057qib7 9415 21 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9415 22 growth growth NN cord-005453-4057qib7 9415 23 in in IN cord-005453-4057qib7 9415 24 a a DT cord-005453-4057qib7 9415 25 mouse mouse NN cord-005453-4057qib7 9415 26 model model NN cord-005453-4057qib7 9415 27 . . . cord-005453-4057qib7 9416 1 Methods method NNS cord-005453-4057qib7 9416 2 : : : cord-005453-4057qib7 9417 1 C3H C3H NNP cord-005453-4057qib7 9417 2 / / SYM cord-005453-4057qib7 9417 3 HeN hen JJ cord-005453-4057qib7 9417 4 mice mouse NNS cord-005453-4057qib7 9417 5 were be VBD cord-005453-4057qib7 9417 6 immunosuppressed immunosuppressed JJ cord-005453-4057qib7 9418 1 ( ( -LRB- cord-005453-4057qib7 9418 2 dexamethasone dexamethasone NN cord-005453-4057qib7 9418 3 4 4 CD cord-005453-4057qib7 9418 4 mg mg NNP cord-005453-4057qib7 9418 5 / / SYM cord-005453-4057qib7 9418 6 L L NNP cord-005453-4057qib7 9418 7 in in IN cord-005453-4057qib7 9418 8 acidified acidified JJ cord-005453-4057qib7 9418 9 drinking drinking NN cord-005453-4057qib7 9418 10 water water NN cord-005453-4057qib7 9418 11 ) ) -RRB- cord-005453-4057qib7 9418 12 and and CC cord-005453-4057qib7 9418 13 then then RB cord-005453-4057qib7 9418 14 infected infect VBN cord-005453-4057qib7 9418 15 intranasally intranasally RB cord-005453-4057qib7 9418 16 with with IN cord-005453-4057qib7 9418 17 P. P. NNP cord-005453-4057qib7 9418 18 murina murina NNP cord-005453-4057qib7 9418 19 ( ( -LRB- cord-005453-4057qib7 9418 20 2 2 CD cord-005453-4057qib7 9418 21 x x SYM cord-005453-4057qib7 9418 22 10 10 CD cord-005453-4057qib7 9418 23 6 6 CD cord-005453-4057qib7 9419 1 /50 /50 NNP cord-005453-4057qib7 9419 2 μL μL NNP cord-005453-4057qib7 9419 3 ) ) -RRB- cord-005453-4057qib7 9419 4 . . . cord-005453-4057qib7 9420 1 Given give VBN cord-005453-4057qib7 9420 2 the the DT cord-005453-4057qib7 9420 3 slow slow JJ cord-005453-4057qib7 9420 4 growth growth NN cord-005453-4057qib7 9420 5 of of IN cord-005453-4057qib7 9420 6 P. P. NNP cord-005453-4057qib7 9420 7 murina murina NN cord-005453-4057qib7 9420 8 , , , cord-005453-4057qib7 9420 9 test test NN cord-005453-4057qib7 9420 10 agents agent NNS cord-005453-4057qib7 9420 11 were be VBD cord-005453-4057qib7 9420 12 administered administer VBN cord-005453-4057qib7 9420 13 at at IN cord-005453-4057qib7 9420 14 the the DT cord-005453-4057qib7 9420 15 same same JJ cord-005453-4057qib7 9420 16 time time NN cord-005453-4057qib7 9420 17 mice mouse NNS cord-005453-4057qib7 9420 18 were be VBD cord-005453-4057qib7 9420 19 inoculated inoculate VBN cord-005453-4057qib7 9420 20 to to TO cord-005453-4057qib7 9420 21 test test VB cord-005453-4057qib7 9420 22 for for IN cord-005453-4057qib7 9420 23 prophylactic prophylactic JJ cord-005453-4057qib7 9420 24 efficacy efficacy NN cord-005453-4057qib7 9420 25 . . . cord-005453-4057qib7 9421 1 Mice mouse NNS cord-005453-4057qib7 9421 2 received receive VBD cord-005453-4057qib7 9421 3 intraperitoneal intraperitoneal JJ cord-005453-4057qib7 9421 4 injections injection NNS cord-005453-4057qib7 9421 5 of of IN cord-005453-4057qib7 9421 6 either either DT cord-005453-4057qib7 9421 7 vehicle vehicle NN cord-005453-4057qib7 9421 8 ( ( -LRB- cord-005453-4057qib7 9421 9 control control NN cord-005453-4057qib7 9421 10 / / SYM cord-005453-4057qib7 9421 11 steroid steroid NN cord-005453-4057qib7 9421 12 [ [ -LRB- cord-005453-4057qib7 9421 13 C C NNP cord-005453-4057qib7 9421 14 / / SYM cord-005453-4057qib7 9421 15 S S NNP cord-005453-4057qib7 9421 16 ] ] -RRB- cord-005453-4057qib7 9421 17 ) ) -RRB- cord-005453-4057qib7 9422 1 , , , cord-005453-4057qib7 9422 2 TMP/ TMP/ NNP cord-005453-4057qib7 9422 3 SMX SMX NNP cord-005453-4057qib7 9422 4 50/250 50/250 CD cord-005453-4057qib7 9422 5 mg mg NNP cord-005453-4057qib7 9422 6 / / SYM cord-005453-4057qib7 9422 7 kg/3x kg/3x NNP cord-005453-4057qib7 9422 8 / / SYM cord-005453-4057qib7 9422 9 week week NN cord-005453-4057qib7 9422 10 ( ( -LRB- cord-005453-4057qib7 9422 11 wk wk NNP cord-005453-4057qib7 9422 12 ) ) -RRB- cord-005453-4057qib7 9422 13 , , , cord-005453-4057qib7 9422 14 caspofungin caspofungin NNP cord-005453-4057qib7 9422 15 5 5 CD cord-005453-4057qib7 9422 16 mg mg NNP cord-005453-4057qib7 9422 17 / / SYM cord-005453-4057qib7 9422 18 kg kg NNP cord-005453-4057qib7 9422 19 once once RB cord-005453-4057qib7 9422 20 daily daily RB cord-005453-4057qib7 9422 21 , , , cord-005453-4057qib7 9422 22 or or CC cord-005453-4057qib7 9422 23 RZF RZF NNP cord-005453-4057qib7 9422 24 5 5 CD cord-005453-4057qib7 9423 1 mg mg NNP cord-005453-4057qib7 9423 2 / / SYM cord-005453-4057qib7 9423 3 kg kg NNP cord-005453-4057qib7 9423 4 or or CC cord-005453-4057qib7 9423 5 0.5 0.5 CD cord-005453-4057qib7 9423 6 mg mg NNP cord-005453-4057qib7 9423 7 / / SYM cord-005453-4057qib7 9423 8 kg kg NNP cord-005453-4057qib7 9423 9 once once RB cord-005453-4057qib7 9423 10 daily daily RB cord-005453-4057qib7 9423 11 , , , cord-005453-4057qib7 9423 12 1x 1x CD cord-005453-4057qib7 9423 13 , , , cord-005453-4057qib7 9423 14 or or CC cord-005453-4057qib7 9423 15 2x 2x CD cord-005453-4057qib7 9423 16 / / SYM cord-005453-4057qib7 9423 17 wk wk NN cord-005453-4057qib7 9423 18 . . . cord-005453-4057qib7 9424 1 After after IN cord-005453-4057qib7 9424 2 a a DT cord-005453-4057qib7 9424 3 6-week 6-week NNP cord-005453-4057qib7 9424 4 dosing dosing NN cord-005453-4057qib7 9424 5 period period NN cord-005453-4057qib7 9424 6 , , , cord-005453-4057qib7 9424 7 mice mouse NNS cord-005453-4057qib7 9424 8 were be VBD cord-005453-4057qib7 9424 9 sacrificed sacrifice VBN cord-005453-4057qib7 9424 10 and and CC cord-005453-4057qib7 9424 11 lung lung NN cord-005453-4057qib7 9424 12 homogenates homogenate NNS cord-005453-4057qib7 9424 13 were be VBD cord-005453-4057qib7 9424 14 processed process VBN cord-005453-4057qib7 9424 15 for for IN cord-005453-4057qib7 9424 16 analysis analysis NN cord-005453-4057qib7 9424 17 to to TO cord-005453-4057qib7 9424 18 quantify quantify VB cord-005453-4057qib7 9424 19 the the DT cord-005453-4057qib7 9424 20 nuclei nucleus NNS cord-005453-4057qib7 9424 21 ( ( -LRB- cord-005453-4057qib7 9424 22 trophic trophic NN cord-005453-4057qib7 9424 23 ) ) -RRB- cord-005453-4057qib7 9424 24 and and CC cord-005453-4057qib7 9424 25 asci asci NNP cord-005453-4057qib7 9424 26 ( ( -LRB- cord-005453-4057qib7 9424 27 cyst cyst NNP cord-005453-4057qib7 9424 28 ) ) -RRB- cord-005453-4057qib7 9424 29 forms form NNS cord-005453-4057qib7 9424 30 of of IN cord-005453-4057qib7 9424 31 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9424 32 . . . cord-005453-4057qib7 9425 1 Prophylaxis prophylaxis NN cord-005453-4057qib7 9425 2 efficacy efficacy NN cord-005453-4057qib7 9425 3 was be VBD cord-005453-4057qib7 9425 4 based base VBN cord-005453-4057qib7 9425 5 on on IN cord-005453-4057qib7 9425 6 reduction reduction NN cord-005453-4057qib7 9425 7 of of IN cord-005453-4057qib7 9425 8 organism organism NN cord-005453-4057qib7 9425 9 burden burden NN cord-005453-4057qib7 9425 10 compared compare VBN cord-005453-4057qib7 9425 11 with with IN cord-005453-4057qib7 9425 12 C C NNP cord-005453-4057qib7 9425 13 / / SYM cord-005453-4057qib7 9425 14 S. S. NNP cord-005453-4057qib7 9425 15 Nuclei Nuclei NNP cord-005453-4057qib7 9425 16 and and CC cord-005453-4057qib7 9425 17 asci asci NNP cord-005453-4057qib7 9425 18 counts count NNS cord-005453-4057qib7 9425 19 were be VBD cord-005453-4057qib7 9425 20 log log NN cord-005453-4057qib7 9425 21 transformed transform VBN cord-005453-4057qib7 9425 22 and and CC cord-005453-4057qib7 9425 23 analyzed analyze VBN cord-005453-4057qib7 9425 24 by by IN cord-005453-4057qib7 9425 25 ANOVA ANOVA NNP cord-005453-4057qib7 9425 26 ; ; , cord-005453-4057qib7 9425 27 individual individual JJ cord-005453-4057qib7 9425 28 groups group NNS cord-005453-4057qib7 9425 29 were be VBD cord-005453-4057qib7 9425 30 compared compare VBN cord-005453-4057qib7 9425 31 by by IN cord-005453-4057qib7 9425 32 the the DT cord-005453-4057qib7 9425 33 Student Student NNP cord-005453-4057qib7 9425 34 - - HYPH cord-005453-4057qib7 9425 35 Newman Newman NNP cord-005453-4057qib7 9425 36 - - HYPH cord-005453-4057qib7 9425 37 Keuls Keuls NNP cord-005453-4057qib7 9425 38 t t NN cord-005453-4057qib7 9425 39 test test NN cord-005453-4057qib7 9425 40 . . . cord-005453-4057qib7 9426 1 Survival survival NN cord-005453-4057qib7 9426 2 rates rate NNS cord-005453-4057qib7 9426 3 were be VBD cord-005453-4057qib7 9426 4 compared compare VBN cord-005453-4057qib7 9426 5 using use VBG cord-005453-4057qib7 9426 6 GraphPad GraphPad NNP cord-005453-4057qib7 9426 7 Prism Prism NNP cord-005453-4057qib7 9426 8 v5 v5 NN cord-005453-4057qib7 9426 9 . . . cord-005453-4057qib7 9427 1 Results result NNS cord-005453-4057qib7 9427 2 : : : cord-005453-4057qib7 9428 1 All all DT cord-005453-4057qib7 9428 2 mice mouse NNS cord-005453-4057qib7 9428 3 in in IN cord-005453-4057qib7 9428 4 the the DT cord-005453-4057qib7 9428 5 RZF RZF NNP cord-005453-4057qib7 9428 6 groups group NNS cord-005453-4057qib7 9428 7 had have VBD cord-005453-4057qib7 9428 8 significantly significantly RB cord-005453-4057qib7 9428 9 reduced reduce VBN cord-005453-4057qib7 9428 10 nuclei nucleus NNS cord-005453-4057qib7 9428 11 and and CC cord-005453-4057qib7 9428 12 asci asci JJ cord-005453-4057qib7 9428 13 burdens burden NNS cord-005453-4057qib7 9428 14 compared compare VBN cord-005453-4057qib7 9428 15 with with IN cord-005453-4057qib7 9428 16 the the DT cord-005453-4057qib7 9428 17 C C NNP cord-005453-4057qib7 9428 18 / / SYM cord-005453-4057qib7 9428 19 S S NNP cord-005453-4057qib7 9428 20 group group NN cord-005453-4057qib7 9428 21 , , , cord-005453-4057qib7 9428 22 and and CC cord-005453-4057qib7 9428 23 all all DT cord-005453-4057qib7 9428 24 but but IN cord-005453-4057qib7 9428 25 the the DT cord-005453-4057qib7 9428 26 lowest low JJS cord-005453-4057qib7 9428 27 doses dose NNS cord-005453-4057qib7 9428 28 of of IN cord-005453-4057qib7 9428 29 RZF RZF NNP cord-005453-4057qib7 9428 30 ( ( -LRB- cord-005453-4057qib7 9428 31 0.5 0.5 CD cord-005453-4057qib7 9428 32 mg mg NNP cord-005453-4057qib7 9428 33 / / SYM cord-005453-4057qib7 9428 34 kg kg NNP cord-005453-4057qib7 9429 1 1x 1x JJ cord-005453-4057qib7 9429 2 or or CC cord-005453-4057qib7 9429 3 2x 2x CD cord-005453-4057qib7 9429 4 / / SYM cord-005453-4057qib7 9429 5 wk wk NN cord-005453-4057qib7 9429 6 ) ) -RRB- cord-005453-4057qib7 9429 7 worked work VBD cord-005453-4057qib7 9429 8 as as RB cord-005453-4057qib7 9429 9 well well RB cord-005453-4057qib7 9429 10 as as IN cord-005453-4057qib7 9429 11 TMP TMP NNP cord-005453-4057qib7 9429 12 / / SYM cord-005453-4057qib7 9429 13 SMX SMX NNP cord-005453-4057qib7 9429 14 at at IN cord-005453-4057qib7 9429 15 reducing reduce VBG cord-005453-4057qib7 9429 16 nuclei nucleus NNS cord-005453-4057qib7 9429 17 levels level NNS cord-005453-4057qib7 9429 18 . . . cord-005453-4057qib7 9430 1 Similarly similarly RB cord-005453-4057qib7 9430 2 , , , cord-005453-4057qib7 9430 3 all all DT cord-005453-4057qib7 9430 4 RZF RZF NNP cord-005453-4057qib7 9430 5 groups group NNS cord-005453-4057qib7 9430 6 except except IN cord-005453-4057qib7 9430 7 for for IN cord-005453-4057qib7 9430 8 the the DT cord-005453-4057qib7 9430 9 0.5 0.5 CD cord-005453-4057qib7 9430 10 mg mg NNP cord-005453-4057qib7 9430 11 / / SYM cord-005453-4057qib7 9430 12 kg kg NNP cord-005453-4057qib7 9430 13 1x 1x CD cord-005453-4057qib7 9430 14 / / SYM cord-005453-4057qib7 9430 15 wk wk NN cord-005453-4057qib7 9430 16 group group NN cord-005453-4057qib7 9430 17 showed show VBD cord-005453-4057qib7 9430 18 reductions reduction NNS cord-005453-4057qib7 9430 19 in in IN cord-005453-4057qib7 9430 20 asci asci NNP cord-005453-4057qib7 9430 21 levels level NNS cord-005453-4057qib7 9430 22 comparable comparable JJ cord-005453-4057qib7 9430 23 to to IN cord-005453-4057qib7 9430 24 that that DT cord-005453-4057qib7 9430 25 of of IN cord-005453-4057qib7 9430 26 TMP TMP NNP cord-005453-4057qib7 9430 27 / / SYM cord-005453-4057qib7 9430 28 SMX SMX NNP cord-005453-4057qib7 9430 29 . . . cord-005453-4057qib7 9431 1 The the DT cord-005453-4057qib7 9431 2 survival survival NN cord-005453-4057qib7 9431 3 rates rate NNS cord-005453-4057qib7 9431 4 were be VBD cord-005453-4057qib7 9431 5 not not RB cord-005453-4057qib7 9431 6 statistically statistically RB cord-005453-4057qib7 9431 7 different different JJ cord-005453-4057qib7 9431 8 between between IN cord-005453-4057qib7 9431 9 treatment treatment NN cord-005453-4057qib7 9431 10 groups group NNS cord-005453-4057qib7 9431 11 . . . cord-005453-4057qib7 9432 1 Conclusions conclusion NNS cord-005453-4057qib7 9432 2 : : : cord-005453-4057qib7 9433 1 RZF RZF NNP cord-005453-4057qib7 9433 2 demonstrated demonstrate VBD cord-005453-4057qib7 9433 3 potent potent JJ cord-005453-4057qib7 9433 4 in in IN cord-005453-4057qib7 9433 5 vivo vivo NN cord-005453-4057qib7 9433 6 efficacy efficacy NN cord-005453-4057qib7 9433 7 for for IN cord-005453-4057qib7 9433 8 prophylaxis prophylaxis NN cord-005453-4057qib7 9433 9 against against IN cord-005453-4057qib7 9433 10 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9433 11 in in IN cord-005453-4057qib7 9433 12 an an DT cord-005453-4057qib7 9433 13 in in IN cord-005453-4057qib7 9433 14 vivo vivo NN cord-005453-4057qib7 9433 15 mouse mouse NN cord-005453-4057qib7 9433 16 infection infection NN cord-005453-4057qib7 9433 17 model model NN cord-005453-4057qib7 9433 18 at at IN cord-005453-4057qib7 9433 19 dose dose NN cord-005453-4057qib7 9433 20 regimens regimen NNS cord-005453-4057qib7 9433 21 much much RB cord-005453-4057qib7 9433 22 lower low JJR cord-005453-4057qib7 9433 23 than than IN cord-005453-4057qib7 9433 24 the the DT cord-005453-4057qib7 9433 25 human human JJ cord-005453-4057qib7 9433 26 equivalent equivalent NN cord-005453-4057qib7 9433 27 Phase Phase NNP cord-005453-4057qib7 9433 28 3 3 CD cord-005453-4057qib7 9433 29 regimen regimen NN cord-005453-4057qib7 9433 30 . . . cord-005453-4057qib7 9434 1 These these DT cord-005453-4057qib7 9434 2 data datum NNS cord-005453-4057qib7 9434 3 support support VBP cord-005453-4057qib7 9434 4 the the DT cord-005453-4057qib7 9434 5 development development NN cord-005453-4057qib7 9434 6 of of IN cord-005453-4057qib7 9434 7 RZF RZF NNP cord-005453-4057qib7 9434 8 for for IN cord-005453-4057qib7 9434 9 the the DT cord-005453-4057qib7 9434 10 prevention prevention NN cord-005453-4057qib7 9434 11 of of IN cord-005453-4057qib7 9434 12 invasive invasive JJ cord-005453-4057qib7 9434 13 fungal fungal JJ cord-005453-4057qib7 9434 14 infections infection NNS cord-005453-4057qib7 9434 15 including include VBG cord-005453-4057qib7 9434 16 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9434 17 pneumonia pneumonia NN cord-005453-4057qib7 9434 18 . . . cord-005453-4057qib7 9435 1 Disclosure disclosure NN cord-005453-4057qib7 9435 2 : : : cord-005453-4057qib7 9435 3 Melanie Melanie NNP cord-005453-4057qib7 9435 4 T. T. NNP cord-005453-4057qib7 9435 5 Cushion Cushion NNP cord-005453-4057qib7 9435 6 : : : cord-005453-4057qib7 9435 7 research research NN cord-005453-4057qib7 9435 8 funding funding NN cord-005453-4057qib7 9435 9 ( ( -LRB- cord-005453-4057qib7 9435 10 Cidara Cidara NNP cord-005453-4057qib7 9435 11 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9435 12 ) ) -RRB- cord-005453-4057qib7 9436 1 Taylor Taylor NNP cord-005453-4057qib7 9436 2 Sandison Sandison NNP cord-005453-4057qib7 9436 3 : : : cord-005453-4057qib7 9436 4 employee employee NN cord-005453-4057qib7 9436 5 , , , cord-005453-4057qib7 9436 6 stockholder stockholder NN cord-005453-4057qib7 9436 7 ( ( -LRB- cord-005453-4057qib7 9436 8 Cidara Cidara NNP cord-005453-4057qib7 9436 9 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9436 10 ) ) -RRB- cord-005453-4057qib7 9437 1 Alan Alan NNP cord-005453-4057qib7 9437 2 Ashbaugh Ashbaugh NNP cord-005453-4057qib7 9437 3 : : : cord-005453-4057qib7 9437 4 Nothing nothing NN cord-005453-4057qib7 9437 5 to to TO cord-005453-4057qib7 9437 6 declare declare VB cord-005453-4057qib7 9437 7 . . . cord-005453-4057qib7 9438 1 Yuhua Yuhua NNP cord-005453-4057qib7 9438 2 Ru Ru NNP cord-005453-4057qib7 9438 3 1,2 1,2 CD cord-005453-4057qib7 9438 4 , , , cord-005453-4057qib7 9438 5 Ziling Ziling NNP cord-005453-4057qib7 9438 6 Zhu Zhu NNP cord-005453-4057qib7 9438 7 1,2 1,2 CD cord-005453-4057qib7 9438 8 , , , cord-005453-4057qib7 9438 9 Yang Yang NNP cord-005453-4057qib7 9438 10 Xu Xu NNP cord-005453-4057qib7 9438 11 1,2 1,2 CD cord-005453-4057qib7 9438 12 , , , cord-005453-4057qib7 9438 13 Suning Suning NNP cord-005453-4057qib7 9438 14 Chen Chen NNP cord-005453-4057qib7 9438 15 1,2 1,2 CD cord-005453-4057qib7 9439 1 , , , cord-005453-4057qib7 9439 2 Xiaowen Xiaowen NNP cord-005453-4057qib7 9439 3 Tang Tang NNP cord-005453-4057qib7 9439 4 Background Background NNP cord-005453-4057qib7 9439 5 : : : cord-005453-4057qib7 9440 1 Immunocompromising immunocompromising NN cord-005453-4057qib7 9440 2 period period NN cord-005453-4057qib7 9440 3 following follow VBG cord-005453-4057qib7 9440 4 allogeneic allogeneic NN cord-005453-4057qib7 9440 5 hematopoietic hematopoietic JJ cord-005453-4057qib7 9440 6 stem stem NN cord-005453-4057qib7 9440 7 cell cell NN cord-005453-4057qib7 9440 8 transplantation transplantation NN cord-005453-4057qib7 9440 9 ( ( -LRB- cord-005453-4057qib7 9440 10 allo allo NN cord-005453-4057qib7 9440 11 - - HYPH cord-005453-4057qib7 9440 12 HSCT HSCT NNP cord-005453-4057qib7 9440 13 ) ) -RRB- cord-005453-4057qib7 9440 14 may may MD cord-005453-4057qib7 9440 15 allow allow VB cord-005453-4057qib7 9440 16 opportunistic opportunistic JJ cord-005453-4057qib7 9440 17 pathogens pathogen NNS cord-005453-4057qib7 9440 18 to to TO cord-005453-4057qib7 9440 19 thrive thrive VB cord-005453-4057qib7 9440 20 and and CC cord-005453-4057qib7 9440 21 result result VB cord-005453-4057qib7 9440 22 in in IN cord-005453-4057qib7 9440 23 fatal fatal JJ cord-005453-4057qib7 9440 24 complications complication NNS cord-005453-4057qib7 9440 25 . . . cord-005453-4057qib7 9441 1 Epstein Epstein NNP cord-005453-4057qib7 9441 2 - - HYPH cord-005453-4057qib7 9441 3 Barr Barr NNP cord-005453-4057qib7 9441 4 virus virus NN cord-005453-4057qib7 9441 5 ( ( -LRB- cord-005453-4057qib7 9441 6 EBV EBV NNP cord-005453-4057qib7 9441 7 ) ) -RRB- cord-005453-4057qib7 9441 8 infects infect VBZ cord-005453-4057qib7 9441 9 more more JJR cord-005453-4057qib7 9441 10 than than IN cord-005453-4057qib7 9441 11 90 90 CD cord-005453-4057qib7 9441 12 % % NN cord-005453-4057qib7 9441 13 of of IN cord-005453-4057qib7 9441 14 Chinese chinese JJ cord-005453-4057qib7 9441 15 population population NN cord-005453-4057qib7 9441 16 , , , cord-005453-4057qib7 9441 17 and and CC cord-005453-4057qib7 9441 18 its -PRON- PRP$ cord-005453-4057qib7 9441 19 reactivation reactivation NN cord-005453-4057qib7 9441 20 after after IN cord-005453-4057qib7 9441 21 HSCT HSCT NNP cord-005453-4057qib7 9441 22 is be VBZ cord-005453-4057qib7 9441 23 one one CD cord-005453-4057qib7 9441 24 of of IN cord-005453-4057qib7 9441 25 the the DT cord-005453-4057qib7 9441 26 major major JJ cord-005453-4057qib7 9441 27 concerns concern NNS cord-005453-4057qib7 9441 28 due due IN cord-005453-4057qib7 9441 29 to to IN cord-005453-4057qib7 9441 30 the the DT cord-005453-4057qib7 9441 31 increased increase VBN cord-005453-4057qib7 9441 32 risk risk NN cord-005453-4057qib7 9441 33 of of IN cord-005453-4057qib7 9441 34 EBV EBV NNP cord-005453-4057qib7 9441 35 diseases disease NNS cord-005453-4057qib7 9441 36 and and CC cord-005453-4057qib7 9441 37 post post JJ cord-005453-4057qib7 9441 38 - - JJ cord-005453-4057qib7 9441 39 transplant transplant JJ cord-005453-4057qib7 9441 40 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 9441 41 disease disease NN cord-005453-4057qib7 9441 42 . . . cord-005453-4057qib7 9442 1 With with IN cord-005453-4057qib7 9442 2 the the DT cord-005453-4057qib7 9442 3 development development NN cord-005453-4057qib7 9442 4 of of IN cord-005453-4057qib7 9442 5 infection infection NN cord-005453-4057qib7 9442 6 prophylaxis prophylaxis NN cord-005453-4057qib7 9442 7 and and CC cord-005453-4057qib7 9442 8 supportive supportive JJ cord-005453-4057qib7 9442 9 care care NN cord-005453-4057qib7 9442 10 after after IN cord-005453-4057qib7 9442 11 HSCT HSCT NNP cord-005453-4057qib7 9442 12 , , , cord-005453-4057qib7 9442 13 demographic demographic JJ cord-005453-4057qib7 9442 14 data datum NNS cord-005453-4057qib7 9442 15 on on IN cord-005453-4057qib7 9442 16 EBV EBV NNP cord-005453-4057qib7 9442 17 reactivation reactivation NN cord-005453-4057qib7 9442 18 post post JJ cord-005453-4057qib7 9442 19 - - JJ cord-005453-4057qib7 9442 20 HSCT HSCT NNP cord-005453-4057qib7 9442 21 needs need VBZ cord-005453-4057qib7 9442 22 to to TO cord-005453-4057qib7 9442 23 be be VB cord-005453-4057qib7 9442 24 updated update VBN cord-005453-4057qib7 9442 25 . . . cord-005453-4057qib7 9443 1 Methods method NNS cord-005453-4057qib7 9443 2 : : : cord-005453-4057qib7 9443 3 We -PRON- PRP cord-005453-4057qib7 9443 4 retrospectively retrospectively RB cord-005453-4057qib7 9443 5 analyzed analyze VBD cord-005453-4057qib7 9443 6 the the DT cord-005453-4057qib7 9443 7 data datum NNS cord-005453-4057qib7 9443 8 of of IN cord-005453-4057qib7 9443 9 patients patient NNS cord-005453-4057qib7 9443 10 who who WP cord-005453-4057qib7 9443 11 received receive VBD cord-005453-4057qib7 9443 12 allo allo NN cord-005453-4057qib7 9443 13 - - HYPH cord-005453-4057qib7 9443 14 HSCT HSCT NNP cord-005453-4057qib7 9443 15 between between IN cord-005453-4057qib7 9443 16 July July NNP cord-005453-4057qib7 9443 17 2011 2011 CD cord-005453-4057qib7 9443 18 and and CC cord-005453-4057qib7 9443 19 July July NNP cord-005453-4057qib7 9443 20 2014 2014 CD cord-005453-4057qib7 9443 21 in in IN cord-005453-4057qib7 9443 22 the the DT cord-005453-4057qib7 9443 23 First First NNP cord-005453-4057qib7 9443 24 Affiliated Affiliated NNP cord-005453-4057qib7 9443 25 Hospital Hospital NNP cord-005453-4057qib7 9443 26 of of IN cord-005453-4057qib7 9443 27 Soochow Soochow NNP cord-005453-4057qib7 9443 28 University University NNP cord-005453-4057qib7 9443 29 . . . cord-005453-4057qib7 9444 1 Quantitative quantitative JJ cord-005453-4057qib7 9444 2 PCR PCR NNP cord-005453-4057qib7 9444 3 ( ( -LRB- cord-005453-4057qib7 9444 4 Q Q NNP cord-005453-4057qib7 9444 5 - - HYPH cord-005453-4057qib7 9444 6 PCR PCR NNP cord-005453-4057qib7 9444 7 ) ) -RRB- cord-005453-4057qib7 9444 8 was be VBD cord-005453-4057qib7 9444 9 used use VBN cord-005453-4057qib7 9444 10 to to TO cord-005453-4057qib7 9444 11 monitor monitor VB cord-005453-4057qib7 9444 12 EBV EBV NNP cord-005453-4057qib7 9444 13 - - HYPH cord-005453-4057qib7 9444 14 DNA dna NN cord-005453-4057qib7 9444 15 load load NN cord-005453-4057qib7 9444 16 in in IN cord-005453-4057qib7 9444 17 peripheral peripheral JJ cord-005453-4057qib7 9444 18 blood blood NN cord-005453-4057qib7 9444 19 dynamically dynamically RB cord-005453-4057qib7 9444 20 . . . cord-005453-4057qib7 9445 1 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 9445 2 ( ( -LRB- cord-005453-4057qib7 9445 3 pre pre JJ cord-005453-4057qib7 9445 4 - - JJ cord-005453-4057qib7 9445 5 HSCT HSCT NNP cord-005453-4057qib7 9445 6 ) ) -RRB- cord-005453-4057qib7 9445 7 followed follow VBN cord-005453-4057qib7 9445 8 by by IN cord-005453-4057qib7 9445 9 acyclovir acyclovir NNP cord-005453-4057qib7 9445 10 was be VBD cord-005453-4057qib7 9445 11 given give VBN cord-005453-4057qib7 9445 12 as as IN cord-005453-4057qib7 9445 13 viral viral JJ cord-005453-4057qib7 9445 14 prophylaxis prophylaxis NN cord-005453-4057qib7 9445 15 . . . cord-005453-4057qib7 9446 1 The the DT cord-005453-4057qib7 9446 2 treatment treatment NN cord-005453-4057qib7 9446 3 protocol protocol NN cord-005453-4057qib7 9446 4 for for IN cord-005453-4057qib7 9446 5 EBV EBV NNP cord-005453-4057qib7 9446 6 reactivation reactivation NN cord-005453-4057qib7 9446 7 consisted consist VBD cord-005453-4057qib7 9446 8 of of IN cord-005453-4057qib7 9446 9 tapering taper VBG cord-005453-4057qib7 9446 10 of of IN cord-005453-4057qib7 9446 11 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 9446 12 agents agent NNS cord-005453-4057qib7 9446 13 , , , cord-005453-4057qib7 9446 14 antiviral antiviral JJ cord-005453-4057qib7 9446 15 agents agent NNS cord-005453-4057qib7 9446 16 ( ( -LRB- cord-005453-4057qib7 9446 17 including include VBG cord-005453-4057qib7 9446 18 ganciclovir ganciclovir NN cord-005453-4057qib7 9446 19 and and CC cord-005453-4057qib7 9446 20 sodium sodium NN cord-005453-4057qib7 9446 21 phosphonatel phosphonatel NN cord-005453-4057qib7 9446 22 ) ) -RRB- cord-005453-4057qib7 9446 23 , , , cord-005453-4057qib7 9446 24 and and CC cord-005453-4057qib7 9446 25 rituximab rituximab VBN cord-005453-4057qib7 9446 26 for for IN cord-005453-4057qib7 9446 27 persistent persistent JJ cord-005453-4057qib7 9446 28 positive positive JJ cord-005453-4057qib7 9446 29 patients patient NNS cord-005453-4057qib7 9446 30 . . . cord-005453-4057qib7 9447 1 Results result NNS cord-005453-4057qib7 9447 2 : : : cord-005453-4057qib7 9448 1 Totally totally RB cord-005453-4057qib7 9448 2 890 890 CD cord-005453-4057qib7 9448 3 cases case NNS cord-005453-4057qib7 9448 4 from from IN cord-005453-4057qib7 9448 5 most most JJS cord-005453-4057qib7 9448 6 of of IN cord-005453-4057qib7 9448 7 the the DT cord-005453-4057qib7 9448 8 provinces province NNS cord-005453-4057qib7 9448 9 in in IN cord-005453-4057qib7 9448 10 China China NNP cord-005453-4057qib7 9448 11 were be VBD cord-005453-4057qib7 9448 12 enrolled enrol VBN cord-005453-4057qib7 9448 13 ( ( -LRB- cord-005453-4057qib7 9448 14 characterized characterize VBN cord-005453-4057qib7 9448 15 in in IN cord-005453-4057qib7 9448 16 Table Table NNP cord-005453-4057qib7 9448 17 1 1 CD cord-005453-4057qib7 9448 18 ) ) -RRB- cord-005453-4057qib7 9448 19 , , , cord-005453-4057qib7 9448 20 among among IN cord-005453-4057qib7 9448 21 whom whom WP cord-005453-4057qib7 9448 22 EBV EBV NNP cord-005453-4057qib7 9448 23 reactivation reactivation NN cord-005453-4057qib7 9448 24 developed develop VBN cord-005453-4057qib7 9448 25 in in IN cord-005453-4057qib7 9448 26 175 175 CD cord-005453-4057qib7 9448 27 recipients recipient NNS cord-005453-4057qib7 9448 28 . . . cord-005453-4057qib7 9449 1 Most Most JJS cord-005453-4057qib7 9449 2 reactivation reactivation NN cord-005453-4057qib7 9449 3 events event NNS cord-005453-4057qib7 9449 4 ( ( -LRB- cord-005453-4057qib7 9449 5 95.4 95.4 CD cord-005453-4057qib7 9449 6 % % NN cord-005453-4057qib7 9449 7 ) ) -RRB- cord-005453-4057qib7 9449 8 occurred occur VBD cord-005453-4057qib7 9449 9 in in IN cord-005453-4057qib7 9449 10 the the DT cord-005453-4057qib7 9449 11 first first JJ cord-005453-4057qib7 9449 12 year year NN cord-005453-4057qib7 9449 13 post post NN cord-005453-4057qib7 9449 14 - - JJ cord-005453-4057qib7 9449 15 HSCT HSCT NNP cord-005453-4057qib7 9449 16 , , , cord-005453-4057qib7 9449 17 with with IN cord-005453-4057qib7 9449 18 a a DT cord-005453-4057qib7 9449 19 peak peak NN cord-005453-4057qib7 9449 20 of of IN cord-005453-4057qib7 9449 21 113.8 113.8 CD cord-005453-4057qib7 9449 22 incidence incidence NN cord-005453-4057qib7 9449 23 rates rate NNS cord-005453-4057qib7 9449 24 per per IN cord-005453-4057qib7 9449 25 100 100 CD cord-005453-4057qib7 9449 26 personyears personyear NNS cord-005453-4057qib7 9449 27 at at IN cord-005453-4057qib7 9449 28 the the DT cord-005453-4057qib7 9449 29 second second JJ cord-005453-4057qib7 9449 30 month month NN cord-005453-4057qib7 9449 31 . . . cord-005453-4057qib7 9450 1 Besides besides RB cord-005453-4057qib7 9450 2 , , , cord-005453-4057qib7 9450 3 more more JJR cord-005453-4057qib7 9450 4 episodes episode NNS cord-005453-4057qib7 9450 5 of of IN cord-005453-4057qib7 9450 6 lateonset lateonset NN cord-005453-4057qib7 9450 7 reactivation reactivation NN cord-005453-4057qib7 9450 8 occurred occur VBD cord-005453-4057qib7 9450 9 in in IN cord-005453-4057qib7 9450 10 patients patient NNS cord-005453-4057qib7 9450 11 receiving receive VBG cord-005453-4057qib7 9450 12 grafts graft NNS cord-005453-4057qib7 9450 13 from from IN cord-005453-4057qib7 9450 14 haploidientical haploidientical JJ cord-005453-4057qib7 9450 15 donors donor NNS cord-005453-4057qib7 9450 16 ( ( -LRB- cord-005453-4057qib7 9450 17 Figure figure NN cord-005453-4057qib7 9450 18 1A 1a NN cord-005453-4057qib7 9450 19 ) ) -RRB- cord-005453-4057qib7 9450 20 . . . cord-005453-4057qib7 9451 1 Multivariate multivariate JJ cord-005453-4057qib7 9451 2 analyses analysis NNS cord-005453-4057qib7 9451 3 revealed reveal VBD cord-005453-4057qib7 9451 4 that that IN cord-005453-4057qib7 9451 5 the the DT cord-005453-4057qib7 9451 6 major major JJ cord-005453-4057qib7 9451 7 impactors impactor NNS cord-005453-4057qib7 9451 8 of of IN cord-005453-4057qib7 9451 9 EBV EBV NNP cord-005453-4057qib7 9451 10 reactivation reactivation NN cord-005453-4057qib7 9451 11 included include VBD cord-005453-4057qib7 9451 12 ATG ATG NNP cord-005453-4057qib7 9451 13 as as IN cord-005453-4057qib7 9451 14 GVHD GVHD NNP cord-005453-4057qib7 9451 15 prophylaxis prophylaxis NN cord-005453-4057qib7 9451 16 ( ( -LRB- cord-005453-4057qib7 9451 17 p p NN cord-005453-4057qib7 9451 18 < < XX cord-005453-4057qib7 9451 19 0.001 0.001 CD cord-005453-4057qib7 9451 20 ) ) -RRB- cord-005453-4057qib7 9451 21 , , , cord-005453-4057qib7 9451 22 HLAmismatched hlamismatched JJ cord-005453-4057qib7 9451 23 donor donor NN cord-005453-4057qib7 9451 24 ( ( -LRB- cord-005453-4057qib7 9451 25 p=0.001 p=0.001 NNP cord-005453-4057qib7 9451 26 ) ) -RRB- cord-005453-4057qib7 9451 27 and and CC cord-005453-4057qib7 9451 28 the the DT cord-005453-4057qib7 9451 29 appearance appearance NN cord-005453-4057qib7 9451 30 of of IN cord-005453-4057qib7 9451 31 chornic chornic NNP cord-005453-4057qib7 9451 32 GVHD GVHD NNP cord-005453-4057qib7 9451 33 ( ( -LRB- cord-005453-4057qib7 9451 34 p=0.042 p=0.042 NNP cord-005453-4057qib7 9451 35 ) ) -RRB- cord-005453-4057qib7 9451 36 . . . cord-005453-4057qib7 9452 1 Cumulative cumulative JJ cord-005453-4057qib7 9452 2 incidence incidence NN cord-005453-4057qib7 9452 3 of of IN cord-005453-4057qib7 9452 4 EBV EBV NNP cord-005453-4057qib7 9452 5 reactivation reactivation NN cord-005453-4057qib7 9452 6 was be VBD cord-005453-4057qib7 9452 7 low low JJ cord-005453-4057qib7 9452 8 ( ( -LRB- cord-005453-4057qib7 9452 9 2.9 2.9 CD cord-005453-4057qib7 9452 10 % % NN cord-005453-4057qib7 9452 11 ) ) -RRB- cord-005453-4057qib7 9452 12 among among IN cord-005453-4057qib7 9452 13 890 890 CD cord-005453-4057qib7 9452 14 patients patient NNS cord-005453-4057qib7 9452 15 with with IN cord-005453-4057qib7 9452 16 no no DT cord-005453-4057qib7 9452 17 major major JJ cord-005453-4057qib7 9452 18 risk risk NN cord-005453-4057qib7 9452 19 factors factor NNS cord-005453-4057qib7 9452 20 , , , cord-005453-4057qib7 9452 21 but but CC cord-005453-4057qib7 9452 22 increased increase VBD cord-005453-4057qib7 9452 23 to to IN cord-005453-4057qib7 9452 24 11.7 11.7 CD cord-005453-4057qib7 9452 25 % % NN cord-005453-4057qib7 9452 26 , , , cord-005453-4057qib7 9452 27 27.3 27.3 CD cord-005453-4057qib7 9452 28 % % NN cord-005453-4057qib7 9452 29 or or CC cord-005453-4057qib7 9452 30 41.9 41.9 CD cord-005453-4057qib7 9452 31 % % NN cord-005453-4057qib7 9452 32 with with IN cord-005453-4057qib7 9452 33 1 1 CD cord-005453-4057qib7 9452 34 , , , cord-005453-4057qib7 9452 35 2 2 CD cord-005453-4057qib7 9452 36 , , , cord-005453-4057qib7 9452 37 and and CC cord-005453-4057qib7 9452 38 3 3 CD cord-005453-4057qib7 9452 39 major major JJ cord-005453-4057qib7 9452 40 risk risk NN cord-005453-4057qib7 9452 41 factors factor NNS cord-005453-4057qib7 9452 42 , , , cord-005453-4057qib7 9452 43 respectively respectively RB cord-005453-4057qib7 9452 44 ( ( -LRB- cord-005453-4057qib7 9452 45 Figure figure NN cord-005453-4057qib7 9452 46 1B 1b CD cord-005453-4057qib7 9452 47 ) ) -RRB- cord-005453-4057qib7 9452 48 . . . cord-005453-4057qib7 9453 1 There there EX cord-005453-4057qib7 9453 2 was be VBD cord-005453-4057qib7 9453 3 no no DT cord-005453-4057qib7 9453 4 statistical statistical JJ cord-005453-4057qib7 9453 5 difference difference NN cord-005453-4057qib7 9453 6 of of IN cord-005453-4057qib7 9453 7 overall overall JJ cord-005453-4057qib7 9453 8 survival survival NN cord-005453-4057qib7 9453 9 between between IN cord-005453-4057qib7 9453 10 people people NNS cord-005453-4057qib7 9453 11 with with IN cord-005453-4057qib7 9453 12 or or CC cord-005453-4057qib7 9453 13 without without IN cord-005453-4057qib7 9453 14 EBV EBV NNP cord-005453-4057qib7 9453 15 reactivation reactivation NN cord-005453-4057qib7 9453 16 ( ( -LRB- cord-005453-4057qib7 9453 17 p=0.871 p=0.871 NN cord-005453-4057qib7 9453 18 ) ) -RRB- cord-005453-4057qib7 9453 19 . . . cord-005453-4057qib7 9454 1 Conclusions conclusion NNS cord-005453-4057qib7 9454 2 : : : cord-005453-4057qib7 9455 1 We -PRON- PRP cord-005453-4057qib7 9455 2 concluded conclude VBD cord-005453-4057qib7 9455 3 that that IN cord-005453-4057qib7 9455 4 there there EX cord-005453-4057qib7 9455 5 are be VBP cord-005453-4057qib7 9455 6 similar similar JJ cord-005453-4057qib7 9455 7 EBV EBV NNP cord-005453-4057qib7 9455 8 reactivation reactivation NN cord-005453-4057qib7 9455 9 impactors impactor NNS cord-005453-4057qib7 9455 10 in in IN cord-005453-4057qib7 9455 11 Chinese chinese JJ cord-005453-4057qib7 9455 12 population population NN cord-005453-4057qib7 9455 13 compared compare VBN cord-005453-4057qib7 9455 14 to to IN cord-005453-4057qib7 9455 15 literatures literature NNS cord-005453-4057qib7 9455 16 , , , cord-005453-4057qib7 9455 17 including include VBG cord-005453-4057qib7 9455 18 ATG ATG NNP cord-005453-4057qib7 9455 19 use use NN cord-005453-4057qib7 9455 20 , , , cord-005453-4057qib7 9455 21 HLA HLA NNP cord-005453-4057qib7 9455 22 - - HYPH cord-005453-4057qib7 9455 23 mismatched mismatch VBN cord-005453-4057qib7 9455 24 donor donor NN cord-005453-4057qib7 9455 25 and and CC cord-005453-4057qib7 9455 26 the the DT cord-005453-4057qib7 9455 27 appearance appearance NN cord-005453-4057qib7 9455 28 of of IN cord-005453-4057qib7 9455 29 chronic chronic JJ cord-005453-4057qib7 9455 30 GVHD GVHD NNP cord-005453-4057qib7 9455 31 . . . cord-005453-4057qib7 9456 1 Additionally additionally RB cord-005453-4057qib7 9456 2 , , , cord-005453-4057qib7 9456 3 incidences incidence NNS cord-005453-4057qib7 9456 4 of of IN cord-005453-4057qib7 9456 5 EBV EBV NNP cord-005453-4057qib7 9456 6 reactivation reactivation NN cord-005453-4057qib7 9456 7 increased increase VBD cord-005453-4057qib7 9456 8 significantly significantly RB cord-005453-4057qib7 9456 9 with with IN cord-005453-4057qib7 9456 10 the the DT cord-005453-4057qib7 9456 11 accumulation accumulation NN cord-005453-4057qib7 9456 12 of of IN cord-005453-4057qib7 9456 13 risk risk NN cord-005453-4057qib7 9456 14 factors factor NNS cord-005453-4057qib7 9456 15 . . . cord-005453-4057qib7 9457 1 However however RB cord-005453-4057qib7 9457 2 , , , cord-005453-4057qib7 9457 3 EBV EBV NNP cord-005453-4057qib7 9457 4 reactivation reactivation NN cord-005453-4057qib7 9457 5 had have VBD cord-005453-4057qib7 9457 6 no no DT cord-005453-4057qib7 9457 7 impact impact NN cord-005453-4057qib7 9457 8 on on IN cord-005453-4057qib7 9457 9 overall overall JJ cord-005453-4057qib7 9457 10 survival survival NN cord-005453-4057qib7 9457 11 in in IN cord-005453-4057qib7 9457 12 current current JJ cord-005453-4057qib7 9457 13 virus virus NN cord-005453-4057qib7 9457 14 management management NN cord-005453-4057qib7 9457 15 protocol protocol NN cord-005453-4057qib7 9457 16 . . . cord-005453-4057qib7 9458 1 Disclosure disclosure NN cord-005453-4057qib7 9458 2 : : : cord-005453-4057qib7 9458 3 Nothing nothing NN cord-005453-4057qib7 9458 4 to to TO cord-005453-4057qib7 9458 5 declare declare VB cord-005453-4057qib7 9458 6 Background background NN cord-005453-4057qib7 9458 7 : : : cord-005453-4057qib7 9459 1 Several several JJ cord-005453-4057qib7 9459 2 studies study NNS cord-005453-4057qib7 9459 3 have have VBP cord-005453-4057qib7 9459 4 shown show VBN cord-005453-4057qib7 9459 5 loss loss NN cord-005453-4057qib7 9459 6 of of IN cord-005453-4057qib7 9459 7 diversity diversity NN cord-005453-4057qib7 9459 8 of of IN cord-005453-4057qib7 9459 9 the the DT cord-005453-4057qib7 9459 10 gut gut NN cord-005453-4057qib7 9459 11 microbiome microbiome NN cord-005453-4057qib7 9459 12 in in IN cord-005453-4057qib7 9459 13 association association NN cord-005453-4057qib7 9459 14 with with IN cord-005453-4057qib7 9459 15 significant significant JJ cord-005453-4057qib7 9459 16 gut gut NN cord-005453-4057qib7 9459 17 injury injury NN cord-005453-4057qib7 9459 18 following follow VBG cord-005453-4057qib7 9459 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 9459 20 stem stem NN cord-005453-4057qib7 9459 21 cell cell NN cord-005453-4057qib7 9459 22 transplantation transplantation NN cord-005453-4057qib7 9459 23 ( ( -LRB- cord-005453-4057qib7 9459 24 HSCT HSCT NNP cord-005453-4057qib7 9459 25 ) ) -RRB- cord-005453-4057qib7 9459 26 . . . cord-005453-4057qib7 9460 1 Prolonged prolonged JJ cord-005453-4057qib7 9460 2 broad broad JJ cord-005453-4057qib7 9460 3 spectrum spectrum NN cord-005453-4057qib7 9460 4 antibiotic antibiotic NN cord-005453-4057qib7 9460 5 use use NN cord-005453-4057qib7 9460 6 further further RB cord-005453-4057qib7 9460 7 promotes promote VBZ cord-005453-4057qib7 9460 8 loss loss NN cord-005453-4057qib7 9460 9 of of IN cord-005453-4057qib7 9460 10 microbiome microbiome NN cord-005453-4057qib7 9460 11 diversity diversity NN cord-005453-4057qib7 9460 12 and and CC cord-005453-4057qib7 9460 13 increases increase VBZ cord-005453-4057qib7 9460 14 the the DT cord-005453-4057qib7 9460 15 risk risk NN cord-005453-4057qib7 9460 16 of of IN cord-005453-4057qib7 9460 17 intestinal intestinal JJ cord-005453-4057qib7 9460 18 colonization colonization NN cord-005453-4057qib7 9460 19 by by IN cord-005453-4057qib7 9460 20 multi multi JJ cord-005453-4057qib7 9460 21 - - JJ cord-005453-4057qib7 9460 22 drug drug JJ cord-005453-4057qib7 9460 23 - - HYPH cord-005453-4057qib7 9460 24 resistant resistant JJ cord-005453-4057qib7 9460 25 ( ( -LRB- cord-005453-4057qib7 9460 26 MDR MDR NNP cord-005453-4057qib7 9460 27 ) ) -RRB- cord-005453-4057qib7 9460 28 bacteria bacteria NNS cord-005453-4057qib7 9460 29 . . . cord-005453-4057qib7 9461 1 Aims aim NNS cord-005453-4057qib7 9461 2 of of IN cord-005453-4057qib7 9461 3 this this DT cord-005453-4057qib7 9461 4 study study NN cord-005453-4057qib7 9461 5 were be VBD cord-005453-4057qib7 9461 6 to to TO cord-005453-4057qib7 9461 7 prospectively prospectively RB cord-005453-4057qib7 9461 8 evaluate evaluate VB cord-005453-4057qib7 9461 9 the the DT cord-005453-4057qib7 9461 10 overall overall JJ cord-005453-4057qib7 9461 11 changes change NNS cord-005453-4057qib7 9461 12 in in IN cord-005453-4057qib7 9461 13 gut gut NN cord-005453-4057qib7 9461 14 microbiome microbiome NN cord-005453-4057qib7 9461 15 composition composition NN cord-005453-4057qib7 9461 16 after after IN cord-005453-4057qib7 9461 17 HSCT HSCT NNP cord-005453-4057qib7 9461 18 and and CC cord-005453-4057qib7 9461 19 differences difference NNS cord-005453-4057qib7 9461 20 in in IN cord-005453-4057qib7 9461 21 patients patient NNS cord-005453-4057qib7 9461 22 colonized colonize VBN cord-005453-4057qib7 9461 23 by by IN cord-005453-4057qib7 9461 24 MDR MDR NNP cord-005453-4057qib7 9461 25 bacteria bacteria NNS cord-005453-4057qib7 9461 26 and and CC cord-005453-4057qib7 9461 27 treated treat VBN cord-005453-4057qib7 9461 28 with with IN cord-005453-4057qib7 9461 29 carbapenems carbapenem NNS cord-005453-4057qib7 9461 30 . . . cord-005453-4057qib7 9462 1 Methods method NNS cord-005453-4057qib7 9463 1 : : : cord-005453-4057qib7 9463 2 We -PRON- PRP cord-005453-4057qib7 9463 3 performed perform VBD cord-005453-4057qib7 9463 4 a a DT cord-005453-4057qib7 9463 5 prospective prospective JJ cord-005453-4057qib7 9463 6 observational observational JJ cord-005453-4057qib7 9463 7 study study NN cord-005453-4057qib7 9463 8 evaluating evaluate VBG cord-005453-4057qib7 9463 9 the the DT cord-005453-4057qib7 9463 10 gut gut NN cord-005453-4057qib7 9463 11 microbiota microbiota NN cord-005453-4057qib7 9463 12 of of IN cord-005453-4057qib7 9463 13 20 20 CD cord-005453-4057qib7 9463 14 hematological hematological JJ cord-005453-4057qib7 9463 15 patients patient NNS cord-005453-4057qib7 9463 16 undergoing undergo VBG cord-005453-4057qib7 9463 17 HSCT HSCT NNP cord-005453-4057qib7 9463 18 , , , cord-005453-4057qib7 9463 19 from from IN cord-005453-4057qib7 9463 20 admission admission NN cord-005453-4057qib7 9463 21 ( ( -LRB- cord-005453-4057qib7 9463 22 T0 T0 NNP cord-005453-4057qib7 9463 23 ) ) -RRB- cord-005453-4057qib7 9463 24 through through IN cord-005453-4057qib7 9463 25 day day NN cord-005453-4057qib7 9463 26 +28 +28 NNP cord-005453-4057qib7 9463 27 ( ( -LRB- cord-005453-4057qib7 9463 28 T5 T5 NNP cord-005453-4057qib7 9463 29 ) ) -RRB- cord-005453-4057qib7 9463 30 . . . cord-005453-4057qib7 9464 1 Fecal fecal JJ cord-005453-4057qib7 9464 2 microbiota microbiota NN cord-005453-4057qib7 9464 3 was be VBD cord-005453-4057qib7 9464 4 assessed assess VBN cord-005453-4057qib7 9464 5 by by IN cord-005453-4057qib7 9464 6 16S 16s JJ cord-005453-4057qib7 9464 7 amplicon amplicon NN cord-005453-4057qib7 9464 8 - - HYPH cord-005453-4057qib7 9464 9 based base VBN cord-005453-4057qib7 9464 10 sequencing sequencing NN cord-005453-4057qib7 9464 11 . . . cord-005453-4057qib7 9465 1 Clinical clinical JJ cord-005453-4057qib7 9465 2 , , , cord-005453-4057qib7 9465 3 and and CC cord-005453-4057qib7 9465 4 microbiological microbiological JJ cord-005453-4057qib7 9465 5 data datum NNS cord-005453-4057qib7 9465 6 as as RB cord-005453-4057qib7 9465 7 well well RB cord-005453-4057qib7 9465 8 as as IN cord-005453-4057qib7 9465 9 fecal fecal JJ cord-005453-4057qib7 9465 10 samples sample NNS cord-005453-4057qib7 9465 11 were be VBD cord-005453-4057qib7 9465 12 collected collect VBN cord-005453-4057qib7 9465 13 every every DT cord-005453-4057qib7 9465 14 7 7 CD cord-005453-4057qib7 9465 15 th th DT cord-005453-4057qib7 9465 16 day day NN cord-005453-4057qib7 9465 17 from from IN cord-005453-4057qib7 9465 18 admission admission NN cord-005453-4057qib7 9465 19 . . . cord-005453-4057qib7 9466 1 Results result NNS cord-005453-4057qib7 9466 2 : : : cord-005453-4057qib7 9467 1 One one CD cord-005453-4057qib7 9467 2 - - HYPH cord-005453-4057qib7 9467 3 hundred hundred CD cord-005453-4057qib7 9467 4 fecal fecal JJ cord-005453-4057qib7 9467 5 samples sample NNS cord-005453-4057qib7 9467 6 were be VBD cord-005453-4057qib7 9467 7 analyzed analyze VBN cord-005453-4057qib7 9467 8 . . . cord-005453-4057qib7 9468 1 Overall overall RB cord-005453-4057qib7 9468 2 , , , cord-005453-4057qib7 9468 3 we -PRON- PRP cord-005453-4057qib7 9468 4 found find VBD cord-005453-4057qib7 9468 5 a a DT cord-005453-4057qib7 9468 6 progressive progressive JJ cord-005453-4057qib7 9468 7 decrease decrease NN cord-005453-4057qib7 9468 8 of of IN cord-005453-4057qib7 9468 9 bacterial bacterial JJ cord-005453-4057qib7 9468 10 richness richness NN cord-005453-4057qib7 9468 11 from from IN cord-005453-4057qib7 9468 12 T0 T0 NNP cord-005453-4057qib7 9468 13 to to IN cord-005453-4057qib7 9468 14 T5 T5 NNP cord-005453-4057qib7 9468 15 , , , cord-005453-4057qib7 9468 16 with with IN cord-005453-4057qib7 9468 17 a a DT cord-005453-4057qib7 9468 18 significant significant JJ cord-005453-4057qib7 9468 19 reduction reduction NN cord-005453-4057qib7 9468 20 of of IN cord-005453-4057qib7 9468 21 Blautia Blautia NNP cord-005453-4057qib7 9468 22 , , , cord-005453-4057qib7 9468 23 Ruminococcus Ruminococcus NNP cord-005453-4057qib7 9468 24 and and CC cord-005453-4057qib7 9468 25 Dorea Dorea NNP cord-005453-4057qib7 9468 26 species specie NNS cord-005453-4057qib7 9468 27 , , , cord-005453-4057qib7 9468 28 which which WDT cord-005453-4057qib7 9468 29 are be VBP cord-005453-4057qib7 9468 30 strictly strictly RB cord-005453-4057qib7 9468 31 associated associate VBN cord-005453-4057qib7 9468 32 with with IN cord-005453-4057qib7 9468 33 the the DT cord-005453-4057qib7 9468 34 production production NN cord-005453-4057qib7 9468 35 of of IN cord-005453-4057qib7 9468 36 short short JJ cord-005453-4057qib7 9468 37 chain chain NN cord-005453-4057qib7 9468 38 fatty fatty JJ cord-005453-4057qib7 9468 39 acids acid NNS cord-005453-4057qib7 9468 40 ( ( -LRB- cord-005453-4057qib7 9468 41 SCA SCA NNP cord-005453-4057qib7 9468 42 ) ) -RRB- cord-005453-4057qib7 9468 43 ( ( -LRB- cord-005453-4057qib7 9468 44 Fig.1 Fig.1 NNP cord-005453-4057qib7 9468 45 ) ) -RRB- cord-005453-4057qib7 9468 46 . . . cord-005453-4057qib7 9469 1 Moreover moreover RB cord-005453-4057qib7 9469 2 , , , cord-005453-4057qib7 9469 3 in in IN cord-005453-4057qib7 9469 4 the the DT cord-005453-4057qib7 9469 5 30 30 CD cord-005453-4057qib7 9469 6 % % NN cord-005453-4057qib7 9469 7 ( ( -LRB- cord-005453-4057qib7 9469 8 no.6 no.6 NNP cord-005453-4057qib7 9469 9 ) ) -RRB- cord-005453-4057qib7 9469 10 of of IN cord-005453-4057qib7 9469 11 patients patient NNS cord-005453-4057qib7 9469 12 who who WP cord-005453-4057qib7 9469 13 were be VBD cord-005453-4057qib7 9469 14 colonized colonize VBN cord-005453-4057qib7 9469 15 by by IN cord-005453-4057qib7 9469 16 ESBL ESBL NNP cord-005453-4057qib7 9469 17 bacteria bacteria NNS cord-005453-4057qib7 9469 18 , , , cord-005453-4057qib7 9469 19 we -PRON- PRP cord-005453-4057qib7 9469 20 observed observe VBD cord-005453-4057qib7 9469 21 a a DT cord-005453-4057qib7 9469 22 significant significant JJ cord-005453-4057qib7 9469 23 reduction reduction NN cord-005453-4057qib7 9469 24 of of IN cord-005453-4057qib7 9469 25 Clostridium clostridium NN cord-005453-4057qib7 9469 26 spp spp NNS cord-005453-4057qib7 9469 27 and and CC cord-005453-4057qib7 9469 28 Bifidobacterium bifidobacterium NN cord-005453-4057qib7 9469 29 species specie NNS cord-005453-4057qib7 9469 30 . . . cord-005453-4057qib7 9470 1 As as IN cord-005453-4057qib7 9470 2 for for IN cord-005453-4057qib7 9470 3 antibiotic antibiotic JJ cord-005453-4057qib7 9470 4 therapies therapy NNS cord-005453-4057qib7 9470 5 , , , cord-005453-4057qib7 9470 6 carbapenems carbapenem NNS cord-005453-4057qib7 9470 7 were be VBD cord-005453-4057qib7 9470 8 used use VBN cord-005453-4057qib7 9470 9 as as IN cord-005453-4057qib7 9470 10 second second JJ cord-005453-4057qib7 9470 11 line line NN cord-005453-4057qib7 9470 12 treatment treatment NN cord-005453-4057qib7 9470 13 of of IN cord-005453-4057qib7 9470 14 febrile febrile JJ cord-005453-4057qib7 9470 15 neutropenia neutropenia NN cord-005453-4057qib7 9470 16 in in IN cord-005453-4057qib7 9470 17 50 50 CD cord-005453-4057qib7 9470 18 % % NN cord-005453-4057qib7 9470 19 ( ( -LRB- cord-005453-4057qib7 9470 20 no no DT cord-005453-4057qib7 9470 21 9 9 CD cord-005453-4057qib7 9470 22 ) ) -RRB- cord-005453-4057qib7 9470 23 of of IN cord-005453-4057qib7 9470 24 cases case NNS cord-005453-4057qib7 9470 25 , , , cord-005453-4057qib7 9470 26 usually usually RB cord-005453-4057qib7 9470 27 associated associate VBN cord-005453-4057qib7 9470 28 with with IN cord-005453-4057qib7 9470 29 aminoglycosides aminoglycoside NNS cord-005453-4057qib7 9470 30 . . . cord-005453-4057qib7 9471 1 In in IN cord-005453-4057qib7 9471 2 patients patient NNS cord-005453-4057qib7 9471 3 treated treat VBN cord-005453-4057qib7 9471 4 with with IN cord-005453-4057qib7 9471 5 meropenem meropenem NNP cord-005453-4057qib7 9471 6 , , , cord-005453-4057qib7 9471 7 a a DT cord-005453-4057qib7 9471 8 strong strong JJ cord-005453-4057qib7 9471 9 decline decline NN cord-005453-4057qib7 9471 10 of of IN cord-005453-4057qib7 9471 11 Blautia Blautia NNP cord-005453-4057qib7 9471 12 and and CC cord-005453-4057qib7 9471 13 Ruminococcus Ruminococcus NNP cord-005453-4057qib7 9471 14 species specie NNS cord-005453-4057qib7 9471 15 was be VBD cord-005453-4057qib7 9471 16 observed observe VBN cord-005453-4057qib7 9471 17 . . . cord-005453-4057qib7 9472 1 This this DT cord-005453-4057qib7 9472 2 finding finding NN cord-005453-4057qib7 9472 3 suggests suggest VBZ cord-005453-4057qib7 9472 4 a a DT cord-005453-4057qib7 9472 5 correlation correlation NN cord-005453-4057qib7 9472 6 between between IN cord-005453-4057qib7 9472 7 carbapenem carbapenem NNP cord-005453-4057qib7 9472 8 regimens regimen NNS cord-005453-4057qib7 9472 9 and and CC cord-005453-4057qib7 9472 10 increase increase NN cord-005453-4057qib7 9472 11 of of IN cord-005453-4057qib7 9472 12 pro pro JJ cord-005453-4057qib7 9472 13 - - JJ cord-005453-4057qib7 9472 14 inflammatory inflammatory JJ cord-005453-4057qib7 9472 15 bacterial bacterial JJ cord-005453-4057qib7 9472 16 strains strain NNS cord-005453-4057qib7 9472 17 in in IN cord-005453-4057qib7 9472 18 the the DT cord-005453-4057qib7 9472 19 gut gut NN cord-005453-4057qib7 9472 20 . . . cord-005453-4057qib7 9473 1 Conclusions conclusion NNS cord-005453-4057qib7 9473 2 : : : cord-005453-4057qib7 9474 1 Our -PRON- PRP$ cord-005453-4057qib7 9474 2 data data NN cord-005453-4057qib7 9474 3 support support VBP cord-005453-4057qib7 9474 4 the the DT cord-005453-4057qib7 9474 5 hypothesis hypothesis NN cord-005453-4057qib7 9474 6 that that DT cord-005453-4057qib7 9474 7 loss loss NN cord-005453-4057qib7 9474 8 of of IN cord-005453-4057qib7 9474 9 intestinal intestinal JJ cord-005453-4057qib7 9474 10 commensals commensal NNS cord-005453-4057qib7 9474 11 that that WDT cord-005453-4057qib7 9474 12 produce produce VBP cord-005453-4057qib7 9474 13 short short JJ cord-005453-4057qib7 9474 14 - - HYPH cord-005453-4057qib7 9474 15 chain chain NN cord-005453-4057qib7 9474 16 fatty fatty JJ cord-005453-4057qib7 9474 17 acids acid NNS cord-005453-4057qib7 9474 18 may may MD cord-005453-4057qib7 9474 19 increase increase VB cord-005453-4057qib7 9474 20 dysbiosis dysbiosis NN cord-005453-4057qib7 9474 21 . . . cord-005453-4057qib7 9475 1 Moreover moreover RB cord-005453-4057qib7 9475 2 , , , cord-005453-4057qib7 9475 3 for for IN cord-005453-4057qib7 9475 4 the the DT cord-005453-4057qib7 9475 5 first first JJ cord-005453-4057qib7 9475 6 time time NN cord-005453-4057qib7 9475 7 we -PRON- PRP cord-005453-4057qib7 9475 8 report report VBP cord-005453-4057qib7 9475 9 significant significant JJ cord-005453-4057qib7 9475 10 and and CC cord-005453-4057qib7 9475 11 progressive progressive JJ cord-005453-4057qib7 9475 12 alterations alteration NNS cord-005453-4057qib7 9475 13 in in IN cord-005453-4057qib7 9475 14 the the DT cord-005453-4057qib7 9475 15 composition composition NN cord-005453-4057qib7 9475 16 of of IN cord-005453-4057qib7 9475 17 Blautia Blautia NNP cord-005453-4057qib7 9475 18 , , , cord-005453-4057qib7 9475 19 Ruminococcus Ruminococcus NNP cord-005453-4057qib7 9475 20 and and CC cord-005453-4057qib7 9475 21 Bifidobacterium Bifidobacterium NNP cord-005453-4057qib7 9475 22 species specie NNS cord-005453-4057qib7 9475 23 in in IN cord-005453-4057qib7 9475 24 patients patient NNS cord-005453-4057qib7 9475 25 treated treat VBN cord-005453-4057qib7 9475 26 with with IN cord-005453-4057qib7 9475 27 meropenem meropenem NNP cord-005453-4057qib7 9475 28 and and CC cord-005453-4057qib7 9475 29 colonized colonize VBN cord-005453-4057qib7 9475 30 by by IN cord-005453-4057qib7 9475 31 ESBL ESBL NNP cord-005453-4057qib7 9475 32 bacteria bacteria NNS cord-005453-4057qib7 9475 33 , , , cord-005453-4057qib7 9475 34 respectively respectively RB cord-005453-4057qib7 9475 35 . . . cord-005453-4057qib7 9476 1 Our -PRON- PRP$ cord-005453-4057qib7 9476 2 findings finding NNS cord-005453-4057qib7 9476 3 offer offer VBP cord-005453-4057qib7 9476 4 potential potential JJ cord-005453-4057qib7 9476 5 modifiable modifiable JJ cord-005453-4057qib7 9476 6 targets target NNS cord-005453-4057qib7 9476 7 to to TO cord-005453-4057qib7 9476 8 reduce reduce VB cord-005453-4057qib7 9476 9 risk risk NN cord-005453-4057qib7 9476 10 of of IN cord-005453-4057qib7 9476 11 colonization colonization NN cord-005453-4057qib7 9476 12 by by IN cord-005453-4057qib7 9476 13 MDR MDR NNP cord-005453-4057qib7 9476 14 bacteria bacteria NNS cord-005453-4057qib7 9476 15 and and CC cord-005453-4057qib7 9476 16 to to TO cord-005453-4057qib7 9476 17 promote promote VB cord-005453-4057qib7 9476 18 a a DT cord-005453-4057qib7 9476 19 carbapenem carbapenem NN cord-005453-4057qib7 9476 20 - - HYPH cord-005453-4057qib7 9476 21 sparing spare VBG cord-005453-4057qib7 9476 22 approach approach NN cord-005453-4057qib7 9476 23 in in IN cord-005453-4057qib7 9476 24 the the DT cord-005453-4057qib7 9476 25 HSCT HSCT NNP cord-005453-4057qib7 9476 26 setting setting NN cord-005453-4057qib7 9476 27 . . . cord-005453-4057qib7 9477 1 Clinical clinical JJ cord-005453-4057qib7 9477 2 Background background NN cord-005453-4057qib7 9477 3 : : : cord-005453-4057qib7 9477 4 CMV CMV NNP cord-005453-4057qib7 9477 5 is be VBZ cord-005453-4057qib7 9477 6 associated associate VBN cord-005453-4057qib7 9477 7 with with IN cord-005453-4057qib7 9477 8 significant significant JJ cord-005453-4057qib7 9477 9 morbidity morbidity NN cord-005453-4057qib7 9477 10 after after IN cord-005453-4057qib7 9477 11 allogeneic allogeneic JJ cord-005453-4057qib7 9477 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 9477 13 stem stem NN cord-005453-4057qib7 9477 14 cell cell NN cord-005453-4057qib7 9477 15 transplantation transplantation NN cord-005453-4057qib7 9477 16 . . . cord-005453-4057qib7 9478 1 Strategies strategy NNS cord-005453-4057qib7 9478 2 to to TO cord-005453-4057qib7 9478 3 prevent prevent VB cord-005453-4057qib7 9478 4 CMV CMV NNP cord-005453-4057qib7 9478 5 - - HYPH cord-005453-4057qib7 9478 6 related relate VBN cord-005453-4057qib7 9478 7 complications complication NNS cord-005453-4057qib7 9478 8 include include VBP cord-005453-4057qib7 9478 9 universal universal JJ cord-005453-4057qib7 9478 10 prophylaxis prophylaxis NN cord-005453-4057qib7 9478 11 and and CC cord-005453-4057qib7 9478 12 preemptive preemptive JJ cord-005453-4057qib7 9478 13 therapy therapy NN cord-005453-4057qib7 9478 14 , , , cord-005453-4057qib7 9478 15 more more RBR cord-005453-4057qib7 9478 16 widely widely RB cord-005453-4057qib7 9478 17 spread spread VBN cord-005453-4057qib7 9478 18 . . . cord-005453-4057qib7 9479 1 Antivirals antiviral NNS cord-005453-4057qib7 9479 2 used use VBD cord-005453-4057qib7 9479 3 for for IN cord-005453-4057qib7 9479 4 CMV CMV NNP cord-005453-4057qib7 9479 5 reactivation reactivation NN cord-005453-4057qib7 9479 6 ( ( -LRB- cord-005453-4057qib7 9479 7 CMV CMV NNP cord-005453-4057qib7 9479 8 - - HYPH cord-005453-4057qib7 9479 9 R R NNP cord-005453-4057qib7 9479 10 ) ) -RRB- cord-005453-4057qib7 9479 11 produces produce VBZ cord-005453-4057qib7 9479 12 major major JJ cord-005453-4057qib7 9479 13 toxicities toxicity NNS cord-005453-4057qib7 9479 14 and and CC cord-005453-4057qib7 9479 15 costs cost NNS cord-005453-4057qib7 9479 16 . . . cord-005453-4057qib7 9480 1 Rate rate NN cord-005453-4057qib7 9480 2 and and CC cord-005453-4057qib7 9480 3 characterization characterization NN cord-005453-4057qib7 9480 4 of of IN cord-005453-4057qib7 9480 5 CMV CMV NNP cord-005453-4057qib7 9480 6 - - HYPH cord-005453-4057qib7 9480 7 R R NNP cord-005453-4057qib7 9480 8 after after IN cord-005453-4057qib7 9480 9 haploidentical haploidentical JJ cord-005453-4057qib7 9480 10 transplantation transplantation NN cord-005453-4057qib7 9480 11 with with IN cord-005453-4057qib7 9480 12 post post JJ cord-005453-4057qib7 9480 13 - - JJ cord-005453-4057qib7 9480 14 transplant transplant NN cord-005453-4057qib7 9480 15 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 9480 16 ( ( -LRB- cord-005453-4057qib7 9480 17 Haplo Haplo NNP cord-005453-4057qib7 9480 18 PT PT NNP cord-005453-4057qib7 9480 19 - - HYPH cord-005453-4057qib7 9480 20 Cy Cy NNP cord-005453-4057qib7 9480 21 ) ) -RRB- cord-005453-4057qib7 9480 22 is be VBZ cord-005453-4057qib7 9480 23 scarce scarce JJ cord-005453-4057qib7 9480 24 . . . cord-005453-4057qib7 9481 1 Our -PRON- PRP$ cord-005453-4057qib7 9481 2 goal goal NN cord-005453-4057qib7 9481 3 was be VBD cord-005453-4057qib7 9481 4 to to TO cord-005453-4057qib7 9481 5 analyze analyze VB cord-005453-4057qib7 9481 6 CMV CMV NNP cord-005453-4057qib7 9481 7 - - HYPH cord-005453-4057qib7 9481 8 R r NN cord-005453-4057qib7 9481 9 rate rate NN cord-005453-4057qib7 9481 10 after after IN cord-005453-4057qib7 9481 11 Haplo Haplo NNP cord-005453-4057qib7 9481 12 PT PT NNP cord-005453-4057qib7 9481 13 - - HYPH cord-005453-4057qib7 9481 14 Cy Cy NNP cord-005453-4057qib7 9481 15 , , , cord-005453-4057qib7 9481 16 outcome outcome NN cord-005453-4057qib7 9481 17 , , , cord-005453-4057qib7 9481 18 complications complication NNS cord-005453-4057qib7 9481 19 associated associate VBN cord-005453-4057qib7 9481 20 to to IN cord-005453-4057qib7 9481 21 therapy therapy NN cord-005453-4057qib7 9481 22 , , , cord-005453-4057qib7 9481 23 and and CC cord-005453-4057qib7 9481 24 to to TO cord-005453-4057qib7 9481 25 identify identify VB cord-005453-4057qib7 9481 26 risk risk NN cord-005453-4057qib7 9481 27 factors factor NNS cord-005453-4057qib7 9481 28 . . . cord-005453-4057qib7 9482 1 Methods method NNS cord-005453-4057qib7 9482 2 : : : cord-005453-4057qib7 9483 1 One one CD cord-005453-4057qib7 9483 2 hundred hundred CD cord-005453-4057qib7 9483 3 Haplo Haplo NNP cord-005453-4057qib7 9483 4 PT PT NNP cord-005453-4057qib7 9483 5 - - HYPH cord-005453-4057qib7 9483 6 Cy Cy NNP cord-005453-4057qib7 9483 7 transplants transplant NNS cord-005453-4057qib7 9483 8 using use VBG cord-005453-4057qib7 9483 9 peripheral peripheral JJ cord-005453-4057qib7 9483 10 blood blood NN cord-005453-4057qib7 9483 11 as as IN cord-005453-4057qib7 9483 12 stem stem NN cord-005453-4057qib7 9483 13 cell cell NN cord-005453-4057qib7 9483 14 source source NN cord-005453-4057qib7 9483 15 performed perform VBN cord-005453-4057qib7 9483 16 between between IN cord-005453-4057qib7 9483 17 2011 2011 CD cord-005453-4057qib7 9483 18 and and CC cord-005453-4057qib7 9483 19 2016 2016 CD cord-005453-4057qib7 9483 20 in in IN cord-005453-4057qib7 9483 21 our -PRON- PRP$ cord-005453-4057qib7 9483 22 center center NN cord-005453-4057qib7 9483 23 have have VBP cord-005453-4057qib7 9483 24 been be VBN cord-005453-4057qib7 9483 25 retrospectively retrospectively RB cord-005453-4057qib7 9483 26 reviewed review VBN cord-005453-4057qib7 9483 27 . . . cord-005453-4057qib7 9484 1 GVHD GVHD NNP cord-005453-4057qib7 9484 2 prophylaxis prophylaxis NN cord-005453-4057qib7 9484 3 consisted consist VBD cord-005453-4057qib7 9484 4 of of IN cord-005453-4057qib7 9484 5 PT PT NNP cord-005453-4057qib7 9484 6 - - HYPH cord-005453-4057qib7 9484 7 Cy Cy NNP cord-005453-4057qib7 9484 8 50 50 CD cord-005453-4057qib7 9484 9 mg/ mg/ NN cord-005453-4057qib7 9484 10 kg kg NNP cord-005453-4057qib7 9484 11 / / SYM cord-005453-4057qib7 9484 12 day day NN cord-005453-4057qib7 9484 13 on on IN cord-005453-4057qib7 9484 14 days day NNS cord-005453-4057qib7 9484 15 +3 +3 NNP cord-005453-4057qib7 9484 16 and and CC cord-005453-4057qib7 9484 17 +4 +4 NN cord-005453-4057qib7 9484 18 , , , cord-005453-4057qib7 9484 19 MMF mmf NN cord-005453-4057qib7 9484 20 and and CC cord-005453-4057qib7 9484 21 CsA csa NN cord-005453-4057qib7 9484 22 from from IN cord-005453-4057qib7 9484 23 day day NN cord-005453-4057qib7 9484 24 +5 +5 NFP cord-005453-4057qib7 9484 25 for for IN cord-005453-4057qib7 9484 26 all all DT cord-005453-4057qib7 9484 27 cases case NNS cord-005453-4057qib7 9484 28 . . . cord-005453-4057qib7 9485 1 CMV CMV NNP cord-005453-4057qib7 9485 2 PCR PCR NNP cord-005453-4057qib7 9485 3 was be VBD cord-005453-4057qib7 9485 4 performed perform VBN cord-005453-4057qib7 9485 5 in in IN cord-005453-4057qib7 9485 6 a a DT cord-005453-4057qib7 9485 7 biweekly biweekly JJ cord-005453-4057qib7 9485 8 basis basis NN cord-005453-4057qib7 9485 9 during during IN cord-005453-4057qib7 9485 10 admission admission NN cord-005453-4057qib7 9485 11 for for IN cord-005453-4057qib7 9485 12 transplant transplant NN cord-005453-4057qib7 9485 13 and and CC cord-005453-4057qib7 9485 14 treatment treatment NN cord-005453-4057qib7 9485 15 , , , cord-005453-4057qib7 9485 16 and and CC cord-005453-4057qib7 9485 17 weekly weekly RB cord-005453-4057qib7 9485 18 thereafter thereafter RB cord-005453-4057qib7 9485 19 . . . cord-005453-4057qib7 9486 1 CMV CMV NNP cord-005453-4057qib7 9486 2 - - HYPH cord-005453-4057qib7 9486 3 R R NNP cord-005453-4057qib7 9486 4 was be VBD cord-005453-4057qib7 9486 5 considered consider VBN cord-005453-4057qib7 9486 6 with with IN cord-005453-4057qib7 9486 7 any any DT cord-005453-4057qib7 9486 8 CMV CMV NNP cord-005453-4057qib7 9486 9 DNA dna NN cord-005453-4057qib7 9486 10 level level NN cord-005453-4057qib7 9486 11 by by IN cord-005453-4057qib7 9486 12 PCR PCR NNP cord-005453-4057qib7 9486 13 assay assay NN cord-005453-4057qib7 9486 14 above above IN cord-005453-4057qib7 9486 15 100 100 CD cord-005453-4057qib7 9486 16 copies copy NNS cord-005453-4057qib7 9486 17 / / SYM cord-005453-4057qib7 9486 18 ml ml NN cord-005453-4057qib7 9486 19 . . . cord-005453-4057qib7 9487 1 Prior prior RB cord-005453-4057qib7 9487 2 four four CD cord-005453-4057qib7 9487 3 consecutive consecutive JJ cord-005453-4057qib7 9487 4 negative negative JJ cord-005453-4057qib7 9487 5 weekly weekly JJ cord-005453-4057qib7 9487 6 PCRs pcr NNS cord-005453-4057qib7 9487 7 were be VBD cord-005453-4057qib7 9487 8 needed need VBN cord-005453-4057qib7 9487 9 to to TO cord-005453-4057qib7 9487 10 consider consider VB cord-005453-4057qib7 9487 11 a a DT cord-005453-4057qib7 9487 12 new new JJ cord-005453-4057qib7 9487 13 reactivation reactivation NN cord-005453-4057qib7 9487 14 episode episode NN cord-005453-4057qib7 9487 15 . . . cord-005453-4057qib7 9488 1 Preemptive preemptive JJ cord-005453-4057qib7 9488 2 strategy strategy NN cord-005453-4057qib7 9488 3 was be VBD cord-005453-4057qib7 9488 4 applied apply VBN cord-005453-4057qib7 9488 5 in in IN cord-005453-4057qib7 9488 6 all all DT cord-005453-4057qib7 9488 7 cases case NNS cord-005453-4057qib7 9488 8 . . . cord-005453-4057qib7 9489 1 Data datum NNS cord-005453-4057qib7 9489 2 collected collect VBN cord-005453-4057qib7 9489 3 in in IN cord-005453-4057qib7 9489 4 relation relation NN cord-005453-4057qib7 9489 5 to to IN cord-005453-4057qib7 9489 6 CMV CMV NNP cord-005453-4057qib7 9489 7 - - HYPH cord-005453-4057qib7 9489 8 R R NNP cord-005453-4057qib7 9489 9 included include VBD cord-005453-4057qib7 9489 10 : : : cord-005453-4057qib7 9489 11 CMV CMV NNP cord-005453-4057qib7 9489 12 serostatus serostatus NN cord-005453-4057qib7 9489 13 of of IN cord-005453-4057qib7 9489 14 donor donor NN cord-005453-4057qib7 9489 15 / / SYM cord-005453-4057qib7 9489 16 recipient recipient NN cord-005453-4057qib7 9489 17 ( ( -LRB- cord-005453-4057qib7 9489 18 D D NNP cord-005453-4057qib7 9489 19 / / SYM cord-005453-4057qib7 9489 20 R r NN cord-005453-4057qib7 9489 21 ) ) -RRB- cord-005453-4057qib7 9489 22 , , , cord-005453-4057qib7 9489 23 number number NN cord-005453-4057qib7 9489 24 of of IN cord-005453-4057qib7 9489 25 CMV CMV NNP cord-005453-4057qib7 9489 26 reactivations reactivation NNS cord-005453-4057qib7 9489 27 , , , cord-005453-4057qib7 9489 28 length length NN cord-005453-4057qib7 9489 29 of of IN cord-005453-4057qib7 9489 30 each each DT cord-005453-4057qib7 9489 31 reactivation reactivation NN cord-005453-4057qib7 9489 32 , , , cord-005453-4057qib7 9489 33 antiviral antiviral JJ cord-005453-4057qib7 9489 34 treatment treatment NN cord-005453-4057qib7 9489 35 used use VBN cord-005453-4057qib7 9489 36 , , , cord-005453-4057qib7 9489 37 need need VBP cord-005453-4057qib7 9489 38 for for IN cord-005453-4057qib7 9489 39 admission admission NN cord-005453-4057qib7 9489 40 to to TO cord-005453-4057qib7 9489 41 receive receive VB cord-005453-4057qib7 9489 42 treatment treatment NN cord-005453-4057qib7 9489 43 and and CC cord-005453-4057qib7 9489 44 adverse adverse JJ cord-005453-4057qib7 9489 45 events event NNS cord-005453-4057qib7 9489 46 related relate VBN cord-005453-4057qib7 9489 47 to to IN cord-005453-4057qib7 9489 48 CMV CMV NNP cord-005453-4057qib7 9489 49 reactivation reactivation NN cord-005453-4057qib7 9489 50 and/or and/or CC cord-005453-4057qib7 9489 51 antiviral antiviral JJ cord-005453-4057qib7 9489 52 treatment treatment NN cord-005453-4057qib7 9489 53 . . . cord-005453-4057qib7 9490 1 Results result NNS cord-005453-4057qib7 9490 2 : : : cord-005453-4057qib7 9491 1 Patients patient NNS cord-005453-4057qib7 9491 2 characteristics characteristic NNS cord-005453-4057qib7 9491 3 are be VBP cord-005453-4057qib7 9491 4 summarized summarize VBN cord-005453-4057qib7 9491 5 in in IN cord-005453-4057qib7 9491 6 Table Table NNP cord-005453-4057qib7 9491 7 _SP cord-005453-4057qib7 9491 8 1 1 CD cord-005453-4057qib7 9491 9 . . . cord-005453-4057qib7 9492 1 Among among IN cord-005453-4057qib7 9492 2 100 100 CD cord-005453-4057qib7 9492 3 patients patient NNS cord-005453-4057qib7 9492 4 , , , cord-005453-4057qib7 9492 5 78 78 CD cord-005453-4057qib7 9492 6 of of IN cord-005453-4057qib7 9492 7 them -PRON- PRP cord-005453-4057qib7 9492 8 with with IN cord-005453-4057qib7 9492 9 positive positive JJ cord-005453-4057qib7 9492 10 CMV CMV NNP cord-005453-4057qib7 9492 11 serology serology NN cord-005453-4057qib7 9492 12 , , , cord-005453-4057qib7 9492 13 128 128 CD cord-005453-4057qib7 9492 14 episodes episode NNS cord-005453-4057qib7 9492 15 of of IN cord-005453-4057qib7 9492 16 CMV CMV NNP cord-005453-4057qib7 9492 17 - - HYPH cord-005453-4057qib7 9492 18 R R NNP cord-005453-4057qib7 9492 19 were be VBD cord-005453-4057qib7 9492 20 detected detect VBN cord-005453-4057qib7 9492 21 . . . cord-005453-4057qib7 9493 1 Seventysix Seventysix NNP cord-005453-4057qib7 9493 2 patients patient NNS cord-005453-4057qib7 9493 3 ( ( -LRB- cord-005453-4057qib7 9493 4 76 76 CD cord-005453-4057qib7 9493 5 % % NN cord-005453-4057qib7 9493 6 ) ) -RRB- cord-005453-4057qib7 9493 7 had have VBD cord-005453-4057qib7 9493 8 at at RB cord-005453-4057qib7 9493 9 least least RBS cord-005453-4057qib7 9493 10 one one CD cord-005453-4057qib7 9493 11 CMV CMV NNP cord-005453-4057qib7 9493 12 - - HYPH cord-005453-4057qib7 9493 13 R R NNP cord-005453-4057qib7 9493 14 in in IN cord-005453-4057qib7 9493 15 a a DT cord-005453-4057qib7 9493 16 median median NN cord-005453-4057qib7 9493 17 of of IN cord-005453-4057qib7 9493 18 30 30 CD cord-005453-4057qib7 9493 19 days day NNS cord-005453-4057qib7 9493 20 after after IN cord-005453-4057qib7 9493 21 transplant transplant NN cord-005453-4057qib7 9493 22 . . . cord-005453-4057qib7 9494 1 None none NN cord-005453-4057qib7 9494 2 of of IN cord-005453-4057qib7 9494 3 them -PRON- PRP cord-005453-4057qib7 9494 4 had have VBD cord-005453-4057qib7 9494 5 CMV CMV NNP cord-005453-4057qib7 9494 6 disease disease NN cord-005453-4057qib7 9494 7 or or CC cord-005453-4057qib7 9494 8 die die VB cord-005453-4057qib7 9494 9 as as IN cord-005453-4057qib7 9494 10 a a DT cord-005453-4057qib7 9494 11 consequence consequence NN cord-005453-4057qib7 9494 12 of of IN cord-005453-4057qib7 9494 13 CMV CMV NNP cord-005453-4057qib7 9494 14 - - HYPH cord-005453-4057qib7 9494 15 R. R. NNP cord-005453-4057qib7 9494 16 Median median JJ cord-005453-4057qib7 9494 17 duration duration NN cord-005453-4057qib7 9494 18 was be VBD cord-005453-4057qib7 9494 19 22 22 CD cord-005453-4057qib7 9494 20 days day NNS cord-005453-4057qib7 9494 21 ( ( -LRB- cord-005453-4057qib7 9494 22 15 15 CD cord-005453-4057qib7 9494 23 - - SYM cord-005453-4057qib7 9494 24 37 37 CD cord-005453-4057qib7 9494 25 ) ) -RRB- cord-005453-4057qib7 9494 26 . . . cord-005453-4057qib7 9495 1 Valganciclovir Valganciclovir NNP cord-005453-4057qib7 9495 2 or or CC cord-005453-4057qib7 9495 3 ganciclovir ganciclovir NNP cord-005453-4057qib7 9495 4 was be VBD cord-005453-4057qib7 9495 5 used use VBN cord-005453-4057qib7 9495 6 in in IN cord-005453-4057qib7 9495 7 101 101 CD cord-005453-4057qib7 9495 8 episodes episode NNS cord-005453-4057qib7 9495 9 ( ( -LRB- cord-005453-4057qib7 9495 10 79 79 CD cord-005453-4057qib7 9495 11 % % NN cord-005453-4057qib7 9495 12 ) ) -RRB- cord-005453-4057qib7 9495 13 . . . cord-005453-4057qib7 9496 1 Foscarnet Foscarnet NNP cord-005453-4057qib7 9496 2 was be VBD cord-005453-4057qib7 9496 3 used use VBN cord-005453-4057qib7 9496 4 in in IN cord-005453-4057qib7 9496 5 43 43 CD cord-005453-4057qib7 9496 6 episodes episode NNS cord-005453-4057qib7 9496 7 ( ( -LRB- cord-005453-4057qib7 9496 8 34 34 CD cord-005453-4057qib7 9496 9 % % NN cord-005453-4057qib7 9496 10 ) ) -RRB- cord-005453-4057qib7 9496 11 . . . cord-005453-4057qib7 9497 1 Six six CD cord-005453-4057qib7 9497 2 of of IN cord-005453-4057qib7 9497 3 the the DT cord-005453-4057qib7 9497 4 episodes episode NNS cord-005453-4057qib7 9497 5 occurred occur VBD cord-005453-4057qib7 9497 6 after after IN cord-005453-4057qib7 9497 7 initial initial JJ cord-005453-4057qib7 9497 8 discharge discharge NN cord-005453-4057qib7 9497 9 , , , cord-005453-4057qib7 9497 10 and and CC cord-005453-4057qib7 9497 11 required require VBN cord-005453-4057qib7 9497 12 re re NN cord-005453-4057qib7 9497 13 - - NN cord-005453-4057qib7 9497 14 admission admission NN cord-005453-4057qib7 9497 15 for for IN cord-005453-4057qib7 9497 16 treatment treatment NN cord-005453-4057qib7 9497 17 , , , cord-005453-4057qib7 9497 18 with with IN cord-005453-4057qib7 9497 19 a a DT cord-005453-4057qib7 9497 20 median median JJ cord-005453-4057qib7 9497 21 length length NN cord-005453-4057qib7 9497 22 of of IN cord-005453-4057qib7 9497 23 hospitalization hospitalization NN cord-005453-4057qib7 9497 24 of of IN cord-005453-4057qib7 9497 25 16 16 CD cord-005453-4057qib7 9497 26 days day NNS cord-005453-4057qib7 9497 27 ( ( -LRB- cord-005453-4057qib7 9497 28 6 6 CD cord-005453-4057qib7 9497 29 - - SYM cord-005453-4057qib7 9497 30 27 27 CD cord-005453-4057qib7 9497 31 ) ) -RRB- cord-005453-4057qib7 9497 32 . . . cord-005453-4057qib7 9498 1 Cytopenias Cytopenias NNP cord-005453-4057qib7 9498 2 requiring require VBG cord-005453-4057qib7 9498 3 transfusion transfusion NN cord-005453-4057qib7 9498 4 or or CC cord-005453-4057qib7 9498 5 G G NNP cord-005453-4057qib7 9498 6 - - HYPH cord-005453-4057qib7 9498 7 CSF csf NN cord-005453-4057qib7 9498 8 support support NN cord-005453-4057qib7 9498 9 occurred occur VBD cord-005453-4057qib7 9498 10 in in IN cord-005453-4057qib7 9498 11 36 36 CD cord-005453-4057qib7 9498 12 episodes episode NNS cord-005453-4057qib7 9498 13 ( ( -LRB- cord-005453-4057qib7 9498 14 36 36 CD cord-005453-4057qib7 9498 15 % % NN cord-005453-4057qib7 9498 16 ) ) -RRB- cord-005453-4057qib7 9498 17 treated treat VBN cord-005453-4057qib7 9498 18 with with IN cord-005453-4057qib7 9498 19 ganciclovir ganciclovir NNS cord-005453-4057qib7 9498 20 or or CC cord-005453-4057qib7 9498 21 valganciclovir valganciclovir NNP cord-005453-4057qib7 9498 22 . . . cord-005453-4057qib7 9499 1 Three three CD cord-005453-4057qib7 9499 2 of of IN cord-005453-4057qib7 9499 3 them -PRON- PRP cord-005453-4057qib7 9499 4 needed need VBD cord-005453-4057qib7 9499 5 further further RB cord-005453-4057qib7 9499 6 CD34 CD34 NNP cord-005453-4057qib7 9499 7 + + CC cord-005453-4057qib7 9499 8 cells cell NNS cord-005453-4057qib7 9499 9 booster booster NN cord-005453-4057qib7 9499 10 for for IN cord-005453-4057qib7 9499 11 graft graft NN cord-005453-4057qib7 9499 12 rescue rescue NN cord-005453-4057qib7 9499 13 . . . cord-005453-4057qib7 9500 1 Mild mild JJ cord-005453-4057qib7 9500 2 acute acute JJ cord-005453-4057qib7 9500 3 renal renal JJ cord-005453-4057qib7 9500 4 failure failure NN cord-005453-4057qib7 9500 5 and and CC cord-005453-4057qib7 9500 6 genital genital JJ cord-005453-4057qib7 9500 7 ulcers ulcer NNS cord-005453-4057qib7 9500 8 were be VBD cord-005453-4057qib7 9500 9 found find VBN cord-005453-4057qib7 9500 10 in in IN cord-005453-4057qib7 9500 11 21 21 CD cord-005453-4057qib7 9500 12 ( ( -LRB- cord-005453-4057qib7 9500 13 49 49 CD cord-005453-4057qib7 9500 14 % % NN cord-005453-4057qib7 9500 15 ) ) -RRB- cord-005453-4057qib7 9500 16 and and CC cord-005453-4057qib7 9500 17 5 5 CD cord-005453-4057qib7 9500 18 ( ( -LRB- cord-005453-4057qib7 9500 19 11,6 11,6 CD cord-005453-4057qib7 9500 20 % % NN cord-005453-4057qib7 9500 21 ) ) -RRB- cord-005453-4057qib7 9500 22 events event NNS cord-005453-4057qib7 9500 23 treated treat VBN cord-005453-4057qib7 9500 24 with with IN cord-005453-4057qib7 9500 25 foscarnet foscarnet NN cord-005453-4057qib7 9500 26 , , , cord-005453-4057qib7 9500 27 respectively respectively RB cord-005453-4057qib7 9500 28 . . . cord-005453-4057qib7 9501 1 No no DT cord-005453-4057qib7 9501 2 cases case NNS cord-005453-4057qib7 9501 3 of of IN cord-005453-4057qib7 9501 4 severe severe JJ cord-005453-4057qib7 9501 5 renal renal JJ cord-005453-4057qib7 9501 6 failure failure NN cord-005453-4057qib7 9501 7 were be VBD cord-005453-4057qib7 9501 8 observed observe VBN cord-005453-4057qib7 9501 9 . . . cord-005453-4057qib7 9502 1 Serological serological JJ cord-005453-4057qib7 9502 2 status status NN cord-005453-4057qib7 9502 3 different different JJ cord-005453-4057qib7 9502 4 than than IN cord-005453-4057qib7 9502 5 negative negative JJ cord-005453-4057qib7 9502 6 / / SYM cord-005453-4057qib7 9502 7 negative negative JJ cord-005453-4057qib7 9502 8 ( ( -LRB- cord-005453-4057qib7 9502 9 N N NNP cord-005453-4057qib7 9502 10 / / SYM cord-005453-4057qib7 9502 11 N N NNP cord-005453-4057qib7 9502 12 ) ) -RRB- cord-005453-4057qib7 9502 13 ( ( -LRB- cord-005453-4057qib7 9502 14 p p NN cord-005453-4057qib7 9502 15 0.001 0.001 CD cord-005453-4057qib7 9502 16 ) ) -RRB- cord-005453-4057qib7 9502 17 and and CC cord-005453-4057qib7 9502 18 older old JJR cord-005453-4057qib7 9502 19 age age NN cord-005453-4057qib7 9502 20 ( ( -LRB- cord-005453-4057qib7 9502 21 46 46 CD cord-005453-4057qib7 9502 22 vs vs IN cord-005453-4057qib7 9502 23 38 38 CD cord-005453-4057qib7 9502 24 years year NNS cord-005453-4057qib7 9502 25 , , , cord-005453-4057qib7 9502 26 p p NN cord-005453-4057qib7 9502 27 0.02 0.02 CD cord-005453-4057qib7 9502 28 ) ) -RRB- cord-005453-4057qib7 9502 29 were be VBD cord-005453-4057qib7 9502 30 significantly significantly RB cord-005453-4057qib7 9502 31 associated associate VBN cord-005453-4057qib7 9502 32 with with IN cord-005453-4057qib7 9502 33 CMV CMV NNP cord-005453-4057qib7 9502 34 - - HYPH cord-005453-4057qib7 9502 35 R. R. NNP cord-005453-4057qib7 9503 1 No no DT cord-005453-4057qib7 9503 2 relationship relationship NN cord-005453-4057qib7 9503 3 was be VBD cord-005453-4057qib7 9503 4 observed observe VBN cord-005453-4057qib7 9503 5 with with IN cord-005453-4057qib7 9503 6 gender gender NN cord-005453-4057qib7 9503 7 , , , cord-005453-4057qib7 9503 8 disease disease NN cord-005453-4057qib7 9503 9 , , , cord-005453-4057qib7 9503 10 donor donor NN cord-005453-4057qib7 9503 11 relationship relationship NN cord-005453-4057qib7 9503 12 , , , cord-005453-4057qib7 9503 13 conditioning conditioning NN cord-005453-4057qib7 9503 14 , , , cord-005453-4057qib7 9503 15 GvHD GvHD NNP cord-005453-4057qib7 9503 16 or or CC cord-005453-4057qib7 9503 17 cells cell NNS cord-005453-4057qib7 9503 18 infused infuse VBN cord-005453-4057qib7 9503 19 . . . cord-005453-4057qib7 9504 1 More More JJR cord-005453-4057qib7 9504 2 than than IN cord-005453-4057qib7 9504 3 2 2 CD cord-005453-4057qib7 9504 4 reactivations reactivation NNS cord-005453-4057qib7 9504 5 were be VBD cord-005453-4057qib7 9504 6 more more RBR cord-005453-4057qib7 9504 7 frequent frequent JJ cord-005453-4057qib7 9504 8 among among IN cord-005453-4057qib7 9504 9 patients patient NNS cord-005453-4057qib7 9504 10 with with IN cord-005453-4057qib7 9504 11 grade grade NN cord-005453-4057qib7 9504 12 II II NNP cord-005453-4057qib7 9504 13 - - HYPH cord-005453-4057qib7 9504 14 IV IV NNP cord-005453-4057qib7 9504 15 acute acute JJ cord-005453-4057qib7 9504 16 GvHD GvHD NNP cord-005453-4057qib7 9504 17 ( ( -LRB- cord-005453-4057qib7 9504 18 aGvHD agvhd NN cord-005453-4057qib7 9504 19 ) ) -RRB- cord-005453-4057qib7 9504 20 and and CC cord-005453-4057qib7 9504 21 moderate moderate JJ cord-005453-4057qib7 9504 22 - - HYPH cord-005453-4057qib7 9504 23 severe severe JJ cord-005453-4057qib7 9504 24 chronic chronic NN cord-005453-4057qib7 9504 25 GvHD gvhd NN cord-005453-4057qib7 9504 26 ( ( -LRB- cord-005453-4057qib7 9504 27 cGvHD cgvhd NN cord-005453-4057qib7 9504 28 ) ) -RRB- cord-005453-4057qib7 9504 29 . . . cord-005453-4057qib7 9505 1 Conclusions conclusion NNS cord-005453-4057qib7 9505 2 : : : cord-005453-4057qib7 9506 1 In in IN cord-005453-4057qib7 9506 2 our -PRON- PRP$ cord-005453-4057qib7 9506 3 experience experience NN cord-005453-4057qib7 9506 4 , , , cord-005453-4057qib7 9506 5 rate rate NN cord-005453-4057qib7 9506 6 of of IN cord-005453-4057qib7 9506 7 CMV CMV NNP cord-005453-4057qib7 9506 8 - - HYPH cord-005453-4057qib7 9506 9 R R NNP cord-005453-4057qib7 9506 10 after after IN cord-005453-4057qib7 9506 11 unmanipulated unmanipulated JJ cord-005453-4057qib7 9506 12 Haplo Haplo NNP cord-005453-4057qib7 9506 13 PT PT NNP cord-005453-4057qib7 9506 14 - - HYPH cord-005453-4057qib7 9506 15 Cy Cy NNP cord-005453-4057qib7 9506 16 , , , cord-005453-4057qib7 9506 17 using use VBG cord-005453-4057qib7 9506 18 PBSC PBSC NNP cord-005453-4057qib7 9506 19 as as IN cord-005453-4057qib7 9506 20 stem stem NN cord-005453-4057qib7 9506 21 cell cell NN cord-005453-4057qib7 9506 22 source source NN cord-005453-4057qib7 9506 23 , , , cord-005453-4057qib7 9506 24 is be VBZ cord-005453-4057qib7 9506 25 considerably considerably RB cord-005453-4057qib7 9506 26 high high JJ cord-005453-4057qib7 9506 27 . . . cord-005453-4057qib7 9507 1 A a DT cord-005453-4057qib7 9507 2 significant significant JJ cord-005453-4057qib7 9507 3 proportion proportion NN cord-005453-4057qib7 9507 4 of of IN cord-005453-4057qib7 9507 5 patients patient NNS cord-005453-4057qib7 9507 6 presented present VBD cord-005453-4057qib7 9507 7 complications complication NNS cord-005453-4057qib7 9507 8 associated associate VBN cord-005453-4057qib7 9507 9 with with IN cord-005453-4057qib7 9507 10 CMV CMV NNP cord-005453-4057qib7 9507 11 - - HYPH cord-005453-4057qib7 9507 12 R R NNP cord-005453-4057qib7 9507 13 and and CC cord-005453-4057qib7 9507 14 its -PRON- PRP$ cord-005453-4057qib7 9507 15 treatment treatment NN cord-005453-4057qib7 9507 16 . . . cord-005453-4057qib7 9508 1 CMV CMV NNP cord-005453-4057qib7 9508 2 serological serological JJ cord-005453-4057qib7 9508 3 status status NN cord-005453-4057qib7 9508 4 other other JJ cord-005453-4057qib7 9508 5 than than IN cord-005453-4057qib7 9508 6 N N NNP cord-005453-4057qib7 9508 7 / / SYM cord-005453-4057qib7 9508 8 N N NNP cord-005453-4057qib7 9508 9 and and CC cord-005453-4057qib7 9508 10 older old JJR cord-005453-4057qib7 9508 11 age age NN cord-005453-4057qib7 9508 12 are be VBP cord-005453-4057qib7 9508 13 associated associate VBN cord-005453-4057qib7 9508 14 with with IN cord-005453-4057qib7 9508 15 high high JJ cord-005453-4057qib7 9508 16 risk risk NN cord-005453-4057qib7 9508 17 of of IN cord-005453-4057qib7 9508 18 CMV CMV NNP cord-005453-4057qib7 9508 19 - - HYPH cord-005453-4057qib7 9508 20 R. R. NNP cord-005453-4057qib7 9508 21 Patients Patients NNP cord-005453-4057qib7 9508 22 with with IN cord-005453-4057qib7 9508 23 grade grade NN cord-005453-4057qib7 9508 24 II II NNP cord-005453-4057qib7 9508 25 - - HYPH cord-005453-4057qib7 9508 26 IV IV NNP cord-005453-4057qib7 9508 27 aGvHD aGvHD NNP cord-005453-4057qib7 9508 28 are be VBP cord-005453-4057qib7 9508 29 at at IN cord-005453-4057qib7 9508 30 higher high JJR cord-005453-4057qib7 9508 31 risk risk NN cord-005453-4057qib7 9508 32 of of IN cord-005453-4057qib7 9508 33 multiple multiple JJ cord-005453-4057qib7 9508 34 reactivations reactivation NNS cord-005453-4057qib7 9508 35 . . . cord-005453-4057qib7 9509 1 This this DT cord-005453-4057qib7 9509 2 population population NN cord-005453-4057qib7 9509 3 could could MD cord-005453-4057qib7 9509 4 be be VB cord-005453-4057qib7 9509 5 benefited benefit VBN cord-005453-4057qib7 9509 6 from from IN cord-005453-4057qib7 9509 7 primary primary JJ cord-005453-4057qib7 9509 8 prophylaxis prophylaxis NN cord-005453-4057qib7 9509 9 , , , cord-005453-4057qib7 9509 10 in in IN cord-005453-4057qib7 9509 11 order order NN cord-005453-4057qib7 9509 12 to to TO cord-005453-4057qib7 9509 13 decrease decrease VB cord-005453-4057qib7 9509 14 treatment´s treatment´s NNP cord-005453-4057qib7 9509 15 complications complication NNS cord-005453-4057qib7 9509 16 , , , cord-005453-4057qib7 9509 17 re re NNS cord-005453-4057qib7 9509 18 - - NNS cord-005453-4057qib7 9509 19 admissions admission NNS cord-005453-4057qib7 9509 20 and and CC cord-005453-4057qib7 9509 21 costs cost NNS cord-005453-4057qib7 9509 22 . . . cord-005453-4057qib7 9510 1 Disclosure disclosure NN cord-005453-4057qib7 9510 2 : : : cord-005453-4057qib7 9510 3 Nothing nothing NN cord-005453-4057qib7 9510 4 to to TO cord-005453-4057qib7 9510 5 declare declare VB cord-005453-4057qib7 9510 6 . . . cord-005453-4057qib7 9511 1 Impact impact NN cord-005453-4057qib7 9511 2 of of IN cord-005453-4057qib7 9511 3 infectious infectious JJ cord-005453-4057qib7 9511 4 events event NNS cord-005453-4057qib7 9511 5 occurring occur VBG cord-005453-4057qib7 9511 6 during during IN cord-005453-4057qib7 9511 7 the the DT cord-005453-4057qib7 9511 8 first first JJ cord-005453-4057qib7 9511 9 hundred hundred CD cord-005453-4057qib7 9511 10 days day NNS cord-005453-4057qib7 9511 11 after after IN cord-005453-4057qib7 9511 12 hsct hsct NNP cord-005453-4057qib7 9511 13 for for IN cord-005453-4057qib7 9511 14 hematological hematological JJ cord-005453-4057qib7 9511 15 malignancy malignancy NN cord-005453-4057qib7 9511 16 : : : cord-005453-4057qib7 9512 1 A a DT cord-005453-4057qib7 9512 2 monocentric monocentric JJ cord-005453-4057qib7 9512 3 retrospective retrospective JJ cord-005453-4057qib7 9512 4 study study NN cord-005453-4057qib7 9512 5 over over IN cord-005453-4057qib7 9512 6 a a DT cord-005453-4057qib7 9512 7 five five CD cord-005453-4057qib7 9512 8 - - HYPH cord-005453-4057qib7 9512 9 year year NN cord-005453-4057qib7 9512 10 period period NN cord-005453-4057qib7 9512 11 Marie Marie NNP cord-005453-4057qib7 9512 12 - - HYPH cord-005453-4057qib7 9512 13 Pierre Pierre NNP cord-005453-4057qib7 9512 14 Ledoux Ledoux NNP cord-005453-4057qib7 9512 15 1 1 CD cord-005453-4057qib7 9512 16 , , , cord-005453-4057qib7 9512 17 Célestine Célestine NNP cord-005453-4057qib7 9512 18 Simand Simand NNP cord-005453-4057qib7 9512 19 1,2 1,2 CD cord-005453-4057qib7 9512 20 , , , cord-005453-4057qib7 9512 21 Karin Karin NNP cord-005453-4057qib7 9512 22 Bilger Bilger NNP cord-005453-4057qib7 9512 23 1 1 CD cord-005453-4057qib7 9512 24 , , , cord-005453-4057qib7 9512 25 Annegret Annegret NNP cord-005453-4057qib7 9512 26 Laplace Laplace NNP cord-005453-4057qib7 9512 27 1 1 CD cord-005453-4057qib7 9513 1 , , , cord-005453-4057qib7 9513 2 Bruno Bruno NNP cord-005453-4057qib7 9513 3 Lioure Lioure NNP cord-005453-4057qib7 9513 4 1 1 CD cord-005453-4057qib7 9513 5 Background Background NNP cord-005453-4057qib7 9513 6 : : : cord-005453-4057qib7 9514 1 Patients patient NNS cord-005453-4057qib7 9514 2 undergoing undergo VBG cord-005453-4057qib7 9514 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 9514 4 stem stem NN cord-005453-4057qib7 9514 5 cells cell NNS cord-005453-4057qib7 9514 6 transplantation transplantation NN cord-005453-4057qib7 9514 7 ( ( -LRB- cord-005453-4057qib7 9514 8 HSCT HSCT NNP cord-005453-4057qib7 9514 9 ) ) -RRB- cord-005453-4057qib7 9514 10 for for IN cord-005453-4057qib7 9514 11 hematological hematological JJ cord-005453-4057qib7 9514 12 malignancy malignancy NN cord-005453-4057qib7 9514 13 often often RB cord-005453-4057qib7 9514 14 present present JJ cord-005453-4057qib7 9514 15 with with IN cord-005453-4057qib7 9514 16 infectious infectious JJ cord-005453-4057qib7 9514 17 events event NNS cord-005453-4057qib7 9514 18 in in IN cord-005453-4057qib7 9514 19 the the DT cord-005453-4057qib7 9514 20 early early JJ cord-005453-4057qib7 9514 21 stages stage NNS cord-005453-4057qib7 9514 22 of of IN cord-005453-4057qib7 9514 23 the the DT cord-005453-4057qib7 9514 24 procedure procedure NN cord-005453-4057qib7 9514 25 , , , cord-005453-4057qib7 9514 26 some some DT cord-005453-4057qib7 9514 27 of of IN cord-005453-4057qib7 9514 28 which which WDT cord-005453-4057qib7 9514 29 having have VBG cord-005453-4057qib7 9514 30 a a DT cord-005453-4057qib7 9514 31 documented document VBN cord-005453-4057qib7 9514 32 impact impact NN cord-005453-4057qib7 9514 33 on on IN cord-005453-4057qib7 9514 34 the the DT cord-005453-4057qib7 9514 35 outcome outcome NN cord-005453-4057qib7 9514 36 of of IN cord-005453-4057qib7 9514 37 the the DT cord-005453-4057qib7 9514 38 graft graft NN cord-005453-4057qib7 9514 39 . . . cord-005453-4057qib7 9515 1 For for IN cord-005453-4057qib7 9515 2 instance instance NN cord-005453-4057qib7 9515 3 , , , cord-005453-4057qib7 9515 4 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 9515 5 ( ( -LRB- cord-005453-4057qib7 9515 6 CMV CMV NNP cord-005453-4057qib7 9515 7 ) ) -RRB- cord-005453-4057qib7 9515 8 has have VBZ cord-005453-4057qib7 9515 9 been be VBN cord-005453-4057qib7 9515 10 shown show VBN cord-005453-4057qib7 9515 11 by by IN cord-005453-4057qib7 9515 12 some some DT cord-005453-4057qib7 9515 13 authors author NNS cord-005453-4057qib7 9515 14 to to TO cord-005453-4057qib7 9515 15 have have VB cord-005453-4057qib7 9515 16 a a DT cord-005453-4057qib7 9515 17 protecting protect VBG cord-005453-4057qib7 9515 18 effect effect NN cord-005453-4057qib7 9515 19 against against IN cord-005453-4057qib7 9515 20 relapse relapse NN cord-005453-4057qib7 9515 21 , , , cord-005453-4057qib7 9515 22 whose whose WP$ cord-005453-4057qib7 9515 23 features feature NNS cord-005453-4057qib7 9515 24 remain remain VBP cord-005453-4057qib7 9515 25 to to TO cord-005453-4057qib7 9515 26 be be VB cord-005453-4057qib7 9515 27 elucidated elucidate VBN cord-005453-4057qib7 9515 28 . . . cord-005453-4057qib7 9516 1 We -PRON- PRP cord-005453-4057qib7 9516 2 conducted conduct VBD cord-005453-4057qib7 9516 3 a a DT cord-005453-4057qib7 9516 4 retrospective retrospective JJ cord-005453-4057qib7 9516 5 monocentric monocentric JJ cord-005453-4057qib7 9516 6 study study NN cord-005453-4057qib7 9516 7 regarding regard VBG cord-005453-4057qib7 9516 8 the the DT cord-005453-4057qib7 9516 9 outcome outcome NN cord-005453-4057qib7 9516 10 in in IN cord-005453-4057qib7 9516 11 terms term NNS cord-005453-4057qib7 9516 12 of of IN cord-005453-4057qib7 9516 13 graft graft NN cord-005453-4057qib7 9516 14 versus versus IN cord-005453-4057qib7 9516 15 host host NN cord-005453-4057qib7 9516 16 ( ( -LRB- cord-005453-4057qib7 9516 17 GvHD GvHD NNP cord-005453-4057qib7 9516 18 ) ) -RRB- cord-005453-4057qib7 9516 19 , , , cord-005453-4057qib7 9516 20 relapse relapse NN cord-005453-4057qib7 9516 21 and and CC cord-005453-4057qib7 9516 22 survival survival NN cord-005453-4057qib7 9516 23 of of IN cord-005453-4057qib7 9516 24 224 224 CD cord-005453-4057qib7 9516 25 consecutive consecutive JJ cord-005453-4057qib7 9516 26 patients patient NNS cord-005453-4057qib7 9516 27 over over IN cord-005453-4057qib7 9516 28 a a DT cord-005453-4057qib7 9516 29 period period NN cord-005453-4057qib7 9516 30 of of IN cord-005453-4057qib7 9516 31 5 5 CD cord-005453-4057qib7 9516 32 years year NNS cord-005453-4057qib7 9516 33 , , , cord-005453-4057qib7 9516 34 whether whether IN cord-005453-4057qib7 9516 35 they -PRON- PRP cord-005453-4057qib7 9516 36 presented present VBD cord-005453-4057qib7 9516 37 or or CC cord-005453-4057qib7 9516 38 not not RB cord-005453-4057qib7 9516 39 with with IN cord-005453-4057qib7 9516 40 an an DT cord-005453-4057qib7 9516 41 infectious infectious JJ cord-005453-4057qib7 9516 42 event event NN cord-005453-4057qib7 9516 43 by by IN cord-005453-4057qib7 9516 44 day day NN cord-005453-4057qib7 9516 45 100 100 CD cord-005453-4057qib7 9516 46 among among IN cord-005453-4057qib7 9516 47 the the DT cord-005453-4057qib7 9516 48 following follow VBG cord-005453-4057qib7 9516 49 : : : cord-005453-4057qib7 9516 50 CMV CMV NNP cord-005453-4057qib7 9516 51 viremia viremia NN cord-005453-4057qib7 9516 52 , , , cord-005453-4057qib7 9516 53 Epstein Epstein NNP cord-005453-4057qib7 9516 54 - - HYPH cord-005453-4057qib7 9516 55 Barr Barr NNP cord-005453-4057qib7 9516 56 virus virus NN cord-005453-4057qib7 9516 57 ( ( -LRB- cord-005453-4057qib7 9516 58 EBV EBV NNP cord-005453-4057qib7 9516 59 ) ) -RRB- cord-005453-4057qib7 9516 60 viremia viremia NNP cord-005453-4057qib7 9516 61 , , , cord-005453-4057qib7 9516 62 Human human JJ cord-005453-4057qib7 9516 63 herpes herpe NNS cord-005453-4057qib7 9516 64 virus virus NN cord-005453-4057qib7 9516 65 6 6 CD cord-005453-4057qib7 9516 66 ( ( -LRB- cord-005453-4057qib7 9516 67 HHV6 HHV6 NNP cord-005453-4057qib7 9516 68 ) ) -RRB- cord-005453-4057qib7 9516 69 viremia viremia NN cord-005453-4057qib7 9516 70 , , , cord-005453-4057qib7 9516 71 BK BK NNP cord-005453-4057qib7 9516 72 virus virus NN cord-005453-4057qib7 9516 73 ( ( -LRB- cord-005453-4057qib7 9516 74 BKV BKV NNP cord-005453-4057qib7 9516 75 ) ) -RRB- cord-005453-4057qib7 9516 76 viruria viruria NNS cord-005453-4057qib7 9516 77 , , , cord-005453-4057qib7 9516 78 bacterial bacterial JJ cord-005453-4057qib7 9516 79 bloodstream bloodstream NN cord-005453-4057qib7 9516 80 infection infection NN cord-005453-4057qib7 9516 81 ( ( -LRB- cord-005453-4057qib7 9516 82 BSI BSI NNP cord-005453-4057qib7 9516 83 ) ) -RRB- cord-005453-4057qib7 9516 84 or or CC cord-005453-4057qib7 9516 85 invasive invasive JJ cord-005453-4057qib7 9516 86 fungal fungal JJ cord-005453-4057qib7 9516 87 infection infection NN cord-005453-4057qib7 9516 88 . . . cord-005453-4057qib7 9517 1 Results result NNS cord-005453-4057qib7 9517 2 : : : cord-005453-4057qib7 9518 1 A a DT cord-005453-4057qib7 9518 2 high high JJ cord-005453-4057qib7 9518 3 proportion proportion NN cord-005453-4057qib7 9518 4 of of IN cord-005453-4057qib7 9518 5 CMV CMV NNP cord-005453-4057qib7 9518 6 seropositive seropositive JJ cord-005453-4057qib7 9518 7 recipients recipient NNS cord-005453-4057qib7 9518 8 underwent undergo VBD cord-005453-4057qib7 9518 9 a a DT cord-005453-4057qib7 9518 10 viral viral JJ cord-005453-4057qib7 9518 11 reactivation reactivation NN cord-005453-4057qib7 9518 12 of of IN cord-005453-4057qib7 9518 13 CMV CMV NNP cord-005453-4057qib7 9518 14 by by IN cord-005453-4057qib7 9518 15 day day NN cord-005453-4057qib7 9518 16 100 100 CD cord-005453-4057qib7 9518 17 of of IN cord-005453-4057qib7 9518 18 the the DT cord-005453-4057qib7 9518 19 HSCT HSCT NNP cord-005453-4057qib7 9518 20 : : : cord-005453-4057qib7 9519 1 81 81 CD cord-005453-4057qib7 9519 2 % % NN cord-005453-4057qib7 9519 3 if if IN cord-005453-4057qib7 9519 4 the the DT cord-005453-4057qib7 9519 5 donor donor NN cord-005453-4057qib7 9519 6 is be VBZ cord-005453-4057qib7 9519 7 seronegative seronegative JJ cord-005453-4057qib7 9519 8 and and CC cord-005453-4057qib7 9519 9 74 74 CD cord-005453-4057qib7 9519 10 % % NN cord-005453-4057qib7 9519 11 if if IN cord-005453-4057qib7 9519 12 the the DT cord-005453-4057qib7 9519 13 donor donor NN cord-005453-4057qib7 9519 14 is be VBZ cord-005453-4057qib7 9519 15 seropositive seropositive JJ cord-005453-4057qib7 9519 16 . . . cord-005453-4057qib7 9520 1 We -PRON- PRP cord-005453-4057qib7 9520 2 observed observe VBD cord-005453-4057qib7 9520 3 that that IN cord-005453-4057qib7 9520 4 CMV CMV NNP cord-005453-4057qib7 9520 5 was be VBD cord-005453-4057qib7 9520 6 n't not RB cord-005453-4057qib7 9520 7 associated associate VBN cord-005453-4057qib7 9520 8 with with IN cord-005453-4057qib7 9520 9 a a DT cord-005453-4057qib7 9520 10 lower low JJR cord-005453-4057qib7 9520 11 relapse relapse NN cord-005453-4057qib7 9520 12 rate rate NN cord-005453-4057qib7 9520 13 in in IN cord-005453-4057qib7 9520 14 our -PRON- PRP$ cord-005453-4057qib7 9520 15 cohort cohort NN cord-005453-4057qib7 9520 16 , , , cord-005453-4057qib7 9520 17 and and CC cord-005453-4057qib7 9520 18 data datum NNS cord-005453-4057qib7 9520 19 were be VBD cord-005453-4057qib7 9520 20 n't not RB cord-005453-4057qib7 9520 21 sufficient sufficient JJ cord-005453-4057qib7 9520 22 to to TO cord-005453-4057qib7 9520 23 conclude conclude VB cord-005453-4057qib7 9520 24 firmly firmly RB cord-005453-4057qib7 9520 25 , , , cord-005453-4057qib7 9520 26 but but CC cord-005453-4057qib7 9520 27 showed show VBD cord-005453-4057qib7 9520 28 a a DT cord-005453-4057qib7 9520 29 trend trend NN cord-005453-4057qib7 9520 30 towards towards IN cord-005453-4057qib7 9520 31 a a DT cord-005453-4057qib7 9520 32 worse bad JJR cord-005453-4057qib7 9520 33 acute acute JJ cord-005453-4057qib7 9520 34 GvHD GvHD NNP cord-005453-4057qib7 9520 35 ( ( -LRB- cord-005453-4057qib7 9520 36 hazard hazard NN cord-005453-4057qib7 9520 37 ratio ratio NN cord-005453-4057qib7 9520 38 HR HR NNP cord-005453-4057qib7 9520 39 2.08 2.08 CD cord-005453-4057qib7 9520 40 , , , cord-005453-4057qib7 9521 1 pvalue pvalue NNP cord-005453-4057qib7 9521 2 0.06 0.06 CD cord-005453-4057qib7 9521 3 ) ) -RRB- cord-005453-4057qib7 9521 4 . . . cord-005453-4057qib7 9522 1 No no DT cord-005453-4057qib7 9522 2 significant significant JJ cord-005453-4057qib7 9522 3 correlation correlation NN cord-005453-4057qib7 9522 4 was be VBD cord-005453-4057qib7 9522 5 found find VBN cord-005453-4057qib7 9522 6 for for IN cord-005453-4057qib7 9522 7 EBV EBV NNP cord-005453-4057qib7 9522 8 viremia viremia NN cord-005453-4057qib7 9522 9 . . . cord-005453-4057qib7 9523 1 Occurring occur VBG cord-005453-4057qib7 9523 2 in in IN cord-005453-4057qib7 9523 3 26 26 CD cord-005453-4057qib7 9523 4 % % NN cord-005453-4057qib7 9523 5 of of IN cord-005453-4057qib7 9523 6 our -PRON- PRP$ cord-005453-4057qib7 9523 7 patients patient NNS cord-005453-4057qib7 9523 8 and and CC cord-005453-4057qib7 9523 9 mostly mostly RB cord-005453-4057qib7 9523 10 with with IN cord-005453-4057qib7 9523 11 an an DT cord-005453-4057qib7 9523 12 early early JJ cord-005453-4057qib7 9523 13 timing timing NN cord-005453-4057qib7 9523 14 , , , cord-005453-4057qib7 9523 15 HHV6 HHV6 NNP cord-005453-4057qib7 9523 16 strongly strongly RB cord-005453-4057qib7 9523 17 correlated correlate VBD cord-005453-4057qib7 9523 18 with with IN cord-005453-4057qib7 9523 19 worse bad JJR cord-005453-4057qib7 9523 20 acute acute JJ cord-005453-4057qib7 9523 21 GvHD gvhd NN cord-005453-4057qib7 9523 22 ( ( -LRB- cord-005453-4057qib7 9523 23 HR HR NNP cord-005453-4057qib7 9523 24 3.25 3.25 CD cord-005453-4057qib7 9523 25 , , , cord-005453-4057qib7 9523 26 p p NN cord-005453-4057qib7 9523 27 - - HYPH cord-005453-4057qib7 9523 28 value value NN cord-005453-4057qib7 9523 29 < < XX cord-005453-4057qib7 9523 30 0.001 0.001 CD cord-005453-4057qib7 9523 31 ) ) -RRB- cord-005453-4057qib7 9523 32 but but CC cord-005453-4057qib7 9523 33 its -PRON- PRP$ cord-005453-4057qib7 9523 34 impact impact NN cord-005453-4057qib7 9523 35 on on IN cord-005453-4057qib7 9523 36 survival survival NN cord-005453-4057qib7 9523 37 was be VBD cord-005453-4057qib7 9523 38 not not RB cord-005453-4057qib7 9523 39 significant significant JJ cord-005453-4057qib7 9523 40 . . . cord-005453-4057qib7 9524 1 BKV BKV NNP cord-005453-4057qib7 9524 2 ( ( -LRB- cord-005453-4057qib7 9524 3 27 27 CD cord-005453-4057qib7 9524 4 % % NN cord-005453-4057qib7 9524 5 of of IN cord-005453-4057qib7 9524 6 our -PRON- PRP$ cord-005453-4057qib7 9524 7 patients patient NNS cord-005453-4057qib7 9524 8 ) ) -RRB- cord-005453-4057qib7 9524 9 and and CC cord-005453-4057qib7 9524 10 BSI BSI NNP cord-005453-4057qib7 9524 11 ( ( -LRB- cord-005453-4057qib7 9524 12 46 46 CD cord-005453-4057qib7 9524 13 % % NN cord-005453-4057qib7 9524 14 of of IN cord-005453-4057qib7 9524 15 our -PRON- PRP$ cord-005453-4057qib7 9524 16 patients patient NNS cord-005453-4057qib7 9524 17 ) ) -RRB- cord-005453-4057qib7 9524 18 both both DT cord-005453-4057qib7 9524 19 correlated correlate VBD cord-005453-4057qib7 9524 20 with with IN cord-005453-4057qib7 9524 21 poorer poor JJR cord-005453-4057qib7 9524 22 outcome outcome NN cord-005453-4057qib7 9524 23 in in IN cord-005453-4057qib7 9524 24 terms term NNS cord-005453-4057qib7 9524 25 of of IN cord-005453-4057qib7 9524 26 overall overall JJ cord-005453-4057qib7 9524 27 survival survival NN cord-005453-4057qib7 9524 28 ( ( -LRB- cord-005453-4057qib7 9524 29 logrank logrank NNP cord-005453-4057qib7 9524 30 < < XX cord-005453-4057qib7 9524 31 0.001 0.001 CD cord-005453-4057qib7 9524 32 and and CC cord-005453-4057qib7 9524 33 0.014 0.014 CD cord-005453-4057qib7 9524 34 respectively respectively RB cord-005453-4057qib7 9524 35 ) ) -RRB- cord-005453-4057qib7 9524 36 although although IN cord-005453-4057qib7 9524 37 not not RB cord-005453-4057qib7 9524 38 significantly significantly RB cord-005453-4057qib7 9524 39 associated associate VBN cord-005453-4057qib7 9524 40 with with IN cord-005453-4057qib7 9524 41 relapse relapse NN cord-005453-4057qib7 9524 42 or or CC cord-005453-4057qib7 9524 43 acute acute JJ cord-005453-4057qib7 9524 44 GvHD gvhd NN cord-005453-4057qib7 9524 45 . . . cord-005453-4057qib7 9525 1 Fungal fungal JJ cord-005453-4057qib7 9525 2 infections infection NNS cord-005453-4057qib7 9525 3 were be VBD cord-005453-4057qib7 9525 4 too too RB cord-005453-4057qib7 9525 5 rare rare JJ cord-005453-4057qib7 9525 6 events event NNS cord-005453-4057qib7 9525 7 to to TO cord-005453-4057qib7 9525 8 draw draw VB cord-005453-4057qib7 9525 9 any any DT cord-005453-4057qib7 9525 10 conclusion conclusion NN cord-005453-4057qib7 9525 11 . . . cord-005453-4057qib7 9526 1 Conclusions conclusion NNS cord-005453-4057qib7 9526 2 : : : cord-005453-4057qib7 9527 1 Thus thus RB cord-005453-4057qib7 9527 2 , , , cord-005453-4057qib7 9527 3 contrary contrary JJ cord-005453-4057qib7 9527 4 to to IN cord-005453-4057qib7 9527 5 many many JJ cord-005453-4057qib7 9527 6 studies study NNS cord-005453-4057qib7 9527 7 , , , cord-005453-4057qib7 9527 8 we -PRON- PRP cord-005453-4057qib7 9527 9 found find VBD cord-005453-4057qib7 9527 10 no no DT cord-005453-4057qib7 9527 11 protection protection NN cord-005453-4057qib7 9527 12 against against IN cord-005453-4057qib7 9527 13 relapse relapse NN cord-005453-4057qib7 9527 14 induced induce VBN cord-005453-4057qib7 9527 15 by by IN cord-005453-4057qib7 9527 16 CMV CMV NNP cord-005453-4057qib7 9527 17 , , , cord-005453-4057qib7 9527 18 although although IN cord-005453-4057qib7 9527 19 the the DT cord-005453-4057qib7 9527 20 trend trend NN cord-005453-4057qib7 9527 21 for for IN cord-005453-4057qib7 9527 22 worse bad JJR cord-005453-4057qib7 9527 23 acute acute JJ cord-005453-4057qib7 9527 24 GvHD GvHD NNP cord-005453-4057qib7 9527 25 was be VBD cord-005453-4057qib7 9527 26 obvious obvious JJ cord-005453-4057qib7 9527 27 . . . cord-005453-4057qib7 9528 1 The the DT cord-005453-4057qib7 9528 2 mechanisms mechanism NNS cord-005453-4057qib7 9528 3 behind behind IN cord-005453-4057qib7 9528 4 this this DT cord-005453-4057qib7 9528 5 discordance discordance NN cord-005453-4057qib7 9528 6 could could MD cord-005453-4057qib7 9528 7 include include VB cord-005453-4057qib7 9528 8 early early JJ cord-005453-4057qib7 9528 9 treatment treatment NN cord-005453-4057qib7 9528 10 , , , cord-005453-4057qib7 9528 11 but but CC cord-005453-4057qib7 9528 12 remain remain VBP cord-005453-4057qib7 9528 13 to to TO cord-005453-4057qib7 9528 14 be be VB cord-005453-4057qib7 9528 15 studied study VBN cord-005453-4057qib7 9528 16 . . . cord-005453-4057qib7 9529 1 Whether whether IN cord-005453-4057qib7 9529 2 HHV6 HHV6 NNP cord-005453-4057qib7 9529 3 is be VBZ cord-005453-4057qib7 9529 4 a a DT cord-005453-4057qib7 9529 5 cause cause NN cord-005453-4057qib7 9529 6 rather rather RB cord-005453-4057qib7 9529 7 than than IN cord-005453-4057qib7 9529 8 a a DT cord-005453-4057qib7 9529 9 consequence consequence NN cord-005453-4057qib7 9529 10 of of IN cord-005453-4057qib7 9529 11 acute acute JJ cord-005453-4057qib7 9529 12 GvHD gvhd NN cord-005453-4057qib7 9529 13 or or CC cord-005453-4057qib7 9529 14 its -PRON- PRP$ cord-005453-4057qib7 9529 15 treatment treatment NN cord-005453-4057qib7 9529 16 is be VBZ cord-005453-4057qib7 9529 17 debated debate VBN cord-005453-4057qib7 9529 18 , , , cord-005453-4057qib7 9529 19 but but CC cord-005453-4057qib7 9529 20 the the DT cord-005453-4057qib7 9529 21 correlation correlation NN cord-005453-4057qib7 9529 22 is be VBZ cord-005453-4057qib7 9529 23 strong strong JJ cord-005453-4057qib7 9529 24 and and CC cord-005453-4057qib7 9529 25 the the DT cord-005453-4057qib7 9529 26 sequence sequence NN cord-005453-4057qib7 9529 27 of of IN cord-005453-4057qib7 9529 28 events event NNS cord-005453-4057qib7 9529 29 suggests suggest VBZ cord-005453-4057qib7 9529 30 HHV6 HHV6 NNP cord-005453-4057qib7 9529 31 might may MD cord-005453-4057qib7 9529 32 act act VB cord-005453-4057qib7 9529 33 as as IN cord-005453-4057qib7 9529 34 a a DT cord-005453-4057qib7 9529 35 trigger trigger NN cord-005453-4057qib7 9529 36 for for IN cord-005453-4057qib7 9529 37 GvHD GvHD NNP cord-005453-4057qib7 9529 38 . . . cord-005453-4057qib7 9530 1 The the DT cord-005453-4057qib7 9530 2 association association NN cord-005453-4057qib7 9530 3 between between IN cord-005453-4057qib7 9530 4 BKV BKV NNP cord-005453-4057qib7 9530 5 viruria viruria NNS cord-005453-4057qib7 9530 6 and and CC cord-005453-4057qib7 9530 7 a a DT cord-005453-4057qib7 9530 8 higher high JJR cord-005453-4057qib7 9530 9 mortality mortality NN cord-005453-4057qib7 9530 10 is be VBZ cord-005453-4057qib7 9530 11 in in IN cord-005453-4057qib7 9530 12 contrast contrast NN cord-005453-4057qib7 9530 13 with with IN cord-005453-4057qib7 9530 14 previous previous JJ cord-005453-4057qib7 9530 15 observations observation NNS cord-005453-4057qib7 9530 16 , , , cord-005453-4057qib7 9530 17 and and CC cord-005453-4057qib7 9530 18 the the DT cord-005453-4057qib7 9530 19 lack lack NN cord-005453-4057qib7 9530 20 for for IN cord-005453-4057qib7 9530 21 association association NN cord-005453-4057qib7 9530 22 with with IN cord-005453-4057qib7 9530 23 GvHD GvHD NNP cord-005453-4057qib7 9530 24 and and CC cord-005453-4057qib7 9530 25 relapse relapse NN cord-005453-4057qib7 9530 26 could could MD cord-005453-4057qib7 9530 27 suggest suggest VB cord-005453-4057qib7 9530 28 BKV BKV NNP cord-005453-4057qib7 9530 29 is be VBZ cord-005453-4057qib7 9530 30 a a DT cord-005453-4057qib7 9530 31 surrogate surrogate NN cord-005453-4057qib7 9530 32 for for IN cord-005453-4057qib7 9530 33 poor poor JJ cord-005453-4057qib7 9530 34 immune immune JJ cord-005453-4057qib7 9530 35 recovery recovery NN cord-005453-4057qib7 9530 36 and and CC cord-005453-4057qib7 9530 37 therefore therefore RB cord-005453-4057qib7 9530 38 other other JJ cord-005453-4057qib7 9530 39 causes cause NNS cord-005453-4057qib7 9530 40 of of IN cord-005453-4057qib7 9530 41 non non JJ cord-005453-4057qib7 9530 42 - - JJ cord-005453-4057qib7 9530 43 relapse relapse JJ cord-005453-4057qib7 9530 44 mortality mortality NN cord-005453-4057qib7 9530 45 . . . cord-005453-4057qib7 9531 1 In in IN cord-005453-4057qib7 9531 2 addition addition NN cord-005453-4057qib7 9531 3 to to IN cord-005453-4057qib7 9531 4 the the DT cord-005453-4057qib7 9531 5 direct direct JJ cord-005453-4057qib7 9531 6 lethal lethal JJ cord-005453-4057qib7 9531 7 risk risk NN cord-005453-4057qib7 9531 8 of of IN cord-005453-4057qib7 9531 9 bacteriemia bacteriemia NN cord-005453-4057qib7 9531 10 , , , cord-005453-4057qib7 9531 11 BSI BSI NNP cord-005453-4057qib7 9531 12 also also RB cord-005453-4057qib7 9531 13 are be VBP cord-005453-4057qib7 9531 14 a a DT cord-005453-4057qib7 9531 15 promoter promoter NN cord-005453-4057qib7 9531 16 of of IN cord-005453-4057qib7 9531 17 late late JJ cord-005453-4057qib7 9531 18 non non JJ cord-005453-4057qib7 9531 19 - - JJ cord-005453-4057qib7 9531 20 relapse relapse JJ cord-005453-4057qib7 9531 21 mortality mortality NN cord-005453-4057qib7 9531 22 through through IN cord-005453-4057qib7 9531 23 indirect indirect JJ cord-005453-4057qib7 9531 24 toxicity toxicity NN cord-005453-4057qib7 9531 25 . . . cord-005453-4057qib7 9532 1 Through through IN cord-005453-4057qib7 9532 2 the the DT cord-005453-4057qib7 9532 3 expansion expansion NN cord-005453-4057qib7 9532 4 of of IN cord-005453-4057qib7 9532 5 immune immune JJ cord-005453-4057qib7 9532 6 effectors effector NNS cord-005453-4057qib7 9532 7 they -PRON- PRP cord-005453-4057qib7 9532 8 promote promote VBP cord-005453-4057qib7 9532 9 , , , cord-005453-4057qib7 9532 10 one one PRP cord-005453-4057qib7 9532 11 could could MD cord-005453-4057qib7 9532 12 assume assume VB cord-005453-4057qib7 9532 13 that that IN cord-005453-4057qib7 9532 14 infectious infectious JJ cord-005453-4057qib7 9532 15 events event NNS cord-005453-4057qib7 9532 16 play play VBP cord-005453-4057qib7 9532 17 a a DT cord-005453-4057qib7 9532 18 role role NN cord-005453-4057qib7 9532 19 in in IN cord-005453-4057qib7 9532 20 GvHD gvhd NN cord-005453-4057qib7 9532 21 and and CC cord-005453-4057qib7 9532 22 GvL gvl NN cord-005453-4057qib7 9532 23 , , , cord-005453-4057qib7 9532 24 and and CC cord-005453-4057qib7 9532 25 therefore therefore RB cord-005453-4057qib7 9532 26 have have VBP cord-005453-4057qib7 9532 27 an an DT cord-005453-4057qib7 9532 28 interference interference NN cord-005453-4057qib7 9532 29 with with IN cord-005453-4057qib7 9532 30 relapse relapse NN cord-005453-4057qib7 9532 31 . . . cord-005453-4057qib7 9533 1 However however RB cord-005453-4057qib7 9533 2 , , , cord-005453-4057qib7 9533 3 the the DT cord-005453-4057qib7 9533 4 association association NN cord-005453-4057qib7 9533 5 between between IN cord-005453-4057qib7 9533 6 each each DT cord-005453-4057qib7 9533 7 infectious infectious JJ cord-005453-4057qib7 9533 8 event event NN cord-005453-4057qib7 9533 9 and and CC cord-005453-4057qib7 9533 10 outcome outcome NN cord-005453-4057qib7 9533 11 remains remain VBZ cord-005453-4057qib7 9533 12 to to TO cord-005453-4057qib7 9533 13 be be VB cord-005453-4057qib7 9533 14 clarified clarify VBN cord-005453-4057qib7 9533 15 to to TO cord-005453-4057qib7 9533 16 guide guide VB cord-005453-4057qib7 9533 17 our -PRON- PRP$ cord-005453-4057qib7 9533 18 prophylactic prophylactic JJ cord-005453-4057qib7 9533 19 and and CC cord-005453-4057qib7 9533 20 therapeutic therapeutic JJ cord-005453-4057qib7 9533 21 choices choice NNS cord-005453-4057qib7 9533 22 by by IN cord-005453-4057qib7 9533 23 a a DT cord-005453-4057qib7 9533 24 better well JJR cord-005453-4057qib7 9533 25 understanding understanding NN cord-005453-4057qib7 9533 26 of of IN cord-005453-4057qib7 9533 27 the the DT cord-005453-4057qib7 9533 28 bright bright JJ cord-005453-4057qib7 9533 29 and and CC cord-005453-4057qib7 9533 30 dark dark JJ cord-005453-4057qib7 9533 31 sides side NNS cord-005453-4057qib7 9533 32 of of IN cord-005453-4057qib7 9533 33 infectious infectious JJ cord-005453-4057qib7 9533 34 events event NNS cord-005453-4057qib7 9533 35 . . . cord-005453-4057qib7 9534 1 Disclosure disclosure NN cord-005453-4057qib7 9534 2 Background background NN cord-005453-4057qib7 9534 3 : : : cord-005453-4057qib7 9534 4 Rezafungin Rezafungin NNP cord-005453-4057qib7 9534 5 ( ( -LRB- cord-005453-4057qib7 9534 6 RZF RZF NNP cord-005453-4057qib7 9534 7 ) ) -RRB- cord-005453-4057qib7 9534 8 is be VBZ cord-005453-4057qib7 9534 9 a a DT cord-005453-4057qib7 9534 10 novel novel JJ cord-005453-4057qib7 9534 11 echinocandin echinocandin NNS cord-005453-4057qib7 9534 12 in in IN cord-005453-4057qib7 9534 13 Phase phase NN cord-005453-4057qib7 9534 14 3 3 CD cord-005453-4057qib7 9534 15 development development NN cord-005453-4057qib7 9534 16 for for IN cord-005453-4057qib7 9534 17 treatment treatment NN cord-005453-4057qib7 9534 18 of of IN cord-005453-4057qib7 9534 19 candidaemia candidaemia NN cord-005453-4057qib7 9534 20 and and CC cord-005453-4057qib7 9534 21 invasive invasive JJ cord-005453-4057qib7 9534 22 candidiasis candidiasi NNS cord-005453-4057qib7 9534 23 and and CC cord-005453-4057qib7 9534 24 for for IN cord-005453-4057qib7 9534 25 antifungal antifungal JJ cord-005453-4057qib7 9534 26 prophylaxis prophylaxis NN cord-005453-4057qib7 9534 27 against against IN cord-005453-4057qib7 9534 28 invasive invasive JJ cord-005453-4057qib7 9534 29 fungal fungal JJ cord-005453-4057qib7 9534 30 diseases disease NNS cord-005453-4057qib7 9534 31 caused cause VBN cord-005453-4057qib7 9534 32 by by IN cord-005453-4057qib7 9534 33 Candida Candida NNP cord-005453-4057qib7 9534 34 , , , cord-005453-4057qib7 9534 35 Aspergillus Aspergillus NNP cord-005453-4057qib7 9534 36 , , , cord-005453-4057qib7 9534 37 and and CC cord-005453-4057qib7 9534 38 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9534 39 in in IN cord-005453-4057qib7 9534 40 blood blood NN cord-005453-4057qib7 9534 41 and and CC cord-005453-4057qib7 9534 42 marrow marrow NN cord-005453-4057qib7 9534 43 transplant transplant NN cord-005453-4057qib7 9534 44 patients patient NNS cord-005453-4057qib7 9534 45 . . . cord-005453-4057qib7 9535 1 RZF RZF NNP cord-005453-4057qib7 9535 2 is be VBZ cord-005453-4057qib7 9535 3 differentiated differentiate VBN cord-005453-4057qib7 9535 4 by by IN cord-005453-4057qib7 9535 5 stable stable JJ cord-005453-4057qib7 9535 6 , , , cord-005453-4057qib7 9535 7 prolonged prolonged JJ cord-005453-4057qib7 9535 8 pharmacokinetics pharmacokinetic NNS cord-005453-4057qib7 9535 9 ( ( -LRB- cord-005453-4057qib7 9535 10 PK PK NNP cord-005453-4057qib7 9535 11 ) ) -RRB- cord-005453-4057qib7 9535 12 that that WDT cord-005453-4057qib7 9535 13 allow allow VBP cord-005453-4057qib7 9535 14 for for IN cord-005453-4057qib7 9535 15 once once RB cord-005453-4057qib7 9535 16 - - HYPH cord-005453-4057qib7 9535 17 weekly weekly NN cord-005453-4057qib7 9535 18 dosing dosing NN cord-005453-4057qib7 9535 19 and and CC cord-005453-4057qib7 9535 20 a a DT cord-005453-4057qib7 9535 21 PK PK NNP cord-005453-4057qib7 9535 22 - - HYPH cord-005453-4057qib7 9535 23 pharmacodynamic pharmacodynamic JJ cord-005453-4057qib7 9535 24 ( ( -LRB- cord-005453-4057qib7 9535 25 PD PD NNP cord-005453-4057qib7 9535 26 ) ) -RRB- cord-005453-4057qib7 9535 27 profile profile NN cord-005453-4057qib7 9535 28 correlating correlate VBG cord-005453-4057qib7 9535 29 with with IN cord-005453-4057qib7 9535 30 efficacy efficacy NN cord-005453-4057qib7 9535 31 . . . cord-005453-4057qib7 9536 1 Clinical clinical JJ cord-005453-4057qib7 9536 2 in in IN cord-005453-4057qib7 9536 3 vivo vivo NN cord-005453-4057qib7 9536 4 evaluations evaluation NNS cord-005453-4057qib7 9536 5 of of IN cord-005453-4057qib7 9536 6 drug drug NN cord-005453-4057qib7 9536 7 interaction interaction NN cord-005453-4057qib7 9536 8 potential potential NN cord-005453-4057qib7 9536 9 were be VBD cord-005453-4057qib7 9536 10 performed perform VBN cord-005453-4057qib7 9536 11 proactively proactively RB cord-005453-4057qib7 9536 12 to to TO cord-005453-4057qib7 9536 13 assess assess VB cord-005453-4057qib7 9536 14 the the DT cord-005453-4057qib7 9536 15 risk risk NN cord-005453-4057qib7 9536 16 of of IN cord-005453-4057qib7 9536 17 drug drug NN cord-005453-4057qib7 9536 18 - - HYPH cord-005453-4057qib7 9536 19 drug drug NN cord-005453-4057qib7 9536 20 interactions interaction NNS cord-005453-4057qib7 9536 21 ( ( -LRB- cord-005453-4057qib7 9536 22 DDIs ddi NNS cord-005453-4057qib7 9536 23 ) ) -RRB- cord-005453-4057qib7 9536 24 with with IN cord-005453-4057qib7 9536 25 respect respect NN cord-005453-4057qib7 9536 26 to to IN cord-005453-4057qib7 9536 27 the the DT cord-005453-4057qib7 9536 28 Phase phase NN cord-005453-4057qib7 9536 29 3 3 CD cord-005453-4057qib7 9536 30 dose dose NN cord-005453-4057qib7 9536 31 of of IN cord-005453-4057qib7 9536 32 400 400 CD cord-005453-4057qib7 9536 33 mg mg NNS cord-005453-4057qib7 9536 34 once once RB cord-005453-4057qib7 9536 35 weekly weekly RB cord-005453-4057qib7 9536 36 and and CC cord-005453-4057qib7 9536 37 known know VBN cord-005453-4057qib7 9536 38 PK PK NNP cord-005453-4057qib7 9536 39 exposure exposure NN cord-005453-4057qib7 9536 40 in in IN cord-005453-4057qib7 9536 41 healthy healthy JJ cord-005453-4057qib7 9536 42 individuals individual NNS cord-005453-4057qib7 9536 43 . . . cord-005453-4057qib7 9537 1 Methods method NNS cord-005453-4057qib7 9537 2 : : : cord-005453-4057qib7 9538 1 This this DT cord-005453-4057qib7 9538 2 open open JJ cord-005453-4057qib7 9538 3 - - HYPH cord-005453-4057qib7 9538 4 label label NN cord-005453-4057qib7 9538 5 study study NN cord-005453-4057qib7 9538 6 of of IN cord-005453-4057qib7 9538 7 26 26 CD cord-005453-4057qib7 9538 8 healthy healthy JJ cord-005453-4057qib7 9538 9 inpatients inpatient NNS cord-005453-4057qib7 9538 10 assessed assess VBD cord-005453-4057qib7 9538 11 DDIs ddi NNS cord-005453-4057qib7 9538 12 between between IN cord-005453-4057qib7 9538 13 RZF RZF NNP cord-005453-4057qib7 9538 14 ( ( -LRB- cord-005453-4057qib7 9538 15 as as IN cord-005453-4057qib7 9538 16 perpetrator perpetrator NN cord-005453-4057qib7 9538 17 ) ) -RRB- cord-005453-4057qib7 9538 18 and and CC cord-005453-4057qib7 9538 19 drugs drug NNS cord-005453-4057qib7 9538 20 known know VBN cord-005453-4057qib7 9538 21 to to TO cord-005453-4057qib7 9538 22 have have VB cord-005453-4057qib7 9538 23 interactions interaction NNS cord-005453-4057qib7 9538 24 with with IN cord-005453-4057qib7 9538 25 CYP CYP NNP cord-005453-4057qib7 9538 26 enzymes enzyme NNS cord-005453-4057qib7 9538 27 and and CC cord-005453-4057qib7 9538 28 transporters transporter NNS cord-005453-4057qib7 9538 29 ( ( -LRB- cord-005453-4057qib7 9538 30 probe probe VBP cord-005453-4057qib7 9538 31 drugs drug NNS cord-005453-4057qib7 9538 32 ) ) -RRB- cord-005453-4057qib7 9539 1 : : : cord-005453-4057qib7 9539 2 repaglinide repaglinide NNP cord-005453-4057qib7 9539 3 ( ( -LRB- cord-005453-4057qib7 9539 4 CYP2C8 CYP2C8 NNP cord-005453-4057qib7 9539 5 ) ) -RRB- cord-005453-4057qib7 9539 6 , , , cord-005453-4057qib7 9539 7 metformin metformin NNP cord-005453-4057qib7 9539 8 ( ( -LRB- cord-005453-4057qib7 9539 9 OCT OCT NNP cord-005453-4057qib7 9539 10 / / SYM cord-005453-4057qib7 9539 11 MATE mate NN cord-005453-4057qib7 9539 12 ) ) -RRB- cord-005453-4057qib7 9539 13 , , , cord-005453-4057qib7 9539 14 rosuvastatin rosuvastatin NNP cord-005453-4057qib7 9539 15 ( ( -LRB- cord-005453-4057qib7 9539 16 BCRP BCRP NNP cord-005453-4057qib7 9539 17 / / SYM cord-005453-4057qib7 9539 18 OATP OATP NNP cord-005453-4057qib7 9539 19 ) ) -RRB- cord-005453-4057qib7 9539 20 , , , cord-005453-4057qib7 9539 21 pitavastatin pitavastatin NNP cord-005453-4057qib7 9539 22 ( ( -LRB- cord-005453-4057qib7 9539 23 OATP OATP NNP cord-005453-4057qib7 9539 24 ) ) -RRB- cord-005453-4057qib7 9539 25 , , , cord-005453-4057qib7 9539 26 caffeine caffeine NN cord-005453-4057qib7 9539 27 ( ( -LRB- cord-005453-4057qib7 9539 28 CYP1A2 CYP1A2 NNP cord-005453-4057qib7 9539 29 ) ) -RRB- cord-005453-4057qib7 9539 30 , , , cord-005453-4057qib7 9539 31 efavirenz efavirenz NNP cord-005453-4057qib7 9539 32 ( ( -LRB- cord-005453-4057qib7 9539 33 CYP2B6 CYP2B6 NNP cord-005453-4057qib7 9539 34 ) ) -RRB- cord-005453-4057qib7 9539 35 , , , cord-005453-4057qib7 9539 36 midazolam midazolam NNP cord-005453-4057qib7 9539 37 ( ( -LRB- cord-005453-4057qib7 9539 38 CYP3A4 CYP3A4 NNP cord-005453-4057qib7 9539 39 ) ) -RRB- cord-005453-4057qib7 9539 40 , , , cord-005453-4057qib7 9539 41 and and CC cord-005453-4057qib7 9539 42 digoxin digoxin NN cord-005453-4057qib7 9539 43 ( ( -LRB- cord-005453-4057qib7 9539 44 P p NN cord-005453-4057qib7 9539 45 - - HYPH cord-005453-4057qib7 9539 46 gp gp NN cord-005453-4057qib7 9539 47 ) ) -RRB- cord-005453-4057qib7 9539 48 , , , cord-005453-4057qib7 9539 49 as as RB cord-005453-4057qib7 9539 50 well well RB cord-005453-4057qib7 9539 51 as as IN cord-005453-4057qib7 9539 52 tacrolimus tacrolimus NNP cord-005453-4057qib7 9539 53 , , , cord-005453-4057qib7 9539 54 a a DT cord-005453-4057qib7 9539 55 drug drug NN cord-005453-4057qib7 9539 56 likely likely JJ cord-005453-4057qib7 9539 57 to to TO cord-005453-4057qib7 9539 58 be be VB cord-005453-4057qib7 9539 59 coadministered coadministere VBN cord-005453-4057qib7 9539 60 with with IN cord-005453-4057qib7 9539 61 RZF RZF NNP cord-005453-4057qib7 9539 62 . . . cord-005453-4057qib7 9540 1 An an DT cord-005453-4057qib7 9540 2 initial initial JJ cord-005453-4057qib7 9540 3 dose dose NN cord-005453-4057qib7 9540 4 of of IN cord-005453-4057qib7 9540 5 RZF RZF NNP cord-005453-4057qib7 9540 6 600 600 CD cord-005453-4057qib7 9540 7 mg mg NN cord-005453-4057qib7 9540 8 was be VBD cord-005453-4057qib7 9540 9 administered administer VBN cord-005453-4057qib7 9540 10 on on IN cord-005453-4057qib7 9540 11 the the DT cord-005453-4057qib7 9540 12 first first JJ cord-005453-4057qib7 9540 13 dosing dosing JJ cord-005453-4057qib7 9540 14 day day NN cord-005453-4057qib7 9540 15 , , , cord-005453-4057qib7 9540 16 to to TO cord-005453-4057qib7 9540 17 approximate approximate VB cord-005453-4057qib7 9540 18 a a DT cord-005453-4057qib7 9540 19 steady steady JJ cord-005453-4057qib7 9540 20 state state NN cord-005453-4057qib7 9540 21 plasma plasma NN cord-005453-4057qib7 9540 22 concentration concentration NN cord-005453-4057qib7 9540 23 of of IN cord-005453-4057qib7 9540 24 multiple multiple JJ cord-005453-4057qib7 9540 25 once once RB cord-005453-4057qib7 9540 26 - - HYPH cord-005453-4057qib7 9540 27 weekly weekly JJ cord-005453-4057qib7 9540 28 400-mg 400-mg CD cord-005453-4057qib7 9540 29 doses dose NNS cord-005453-4057qib7 9540 30 , , , cord-005453-4057qib7 9540 31 followed follow VBN cord-005453-4057qib7 9540 32 by by IN cord-005453-4057qib7 9540 33 2 2 CD cord-005453-4057qib7 9540 34 once once RB cord-005453-4057qib7 9540 35 - - HYPH cord-005453-4057qib7 9540 36 weekly weekly JJ cord-005453-4057qib7 9540 37 400-mg 400-mg CD cord-005453-4057qib7 9540 38 doses dose NNS cord-005453-4057qib7 9540 39 on on IN cord-005453-4057qib7 9540 40 days day NNS cord-005453-4057qib7 9540 41 10 10 CD cord-005453-4057qib7 9540 42 and and CC cord-005453-4057qib7 9540 43 15 15 CD cord-005453-4057qib7 9540 44 . . . cord-005453-4057qib7 9541 1 Probe probe NN cord-005453-4057qib7 9541 2 drug drug NN cord-005453-4057qib7 9541 3 cocktails cocktail NNS cord-005453-4057qib7 9541 4 containing contain VBG cord-005453-4057qib7 9541 5 ≥2 ≥2 NNP cord-005453-4057qib7 9541 6 drugs drug NNS cord-005453-4057qib7 9541 7 were be VBD cord-005453-4057qib7 9541 8 administered administer VBN cord-005453-4057qib7 9541 9 , , , cord-005453-4057qib7 9541 10 once once RB cord-005453-4057qib7 9541 11 before before IN cord-005453-4057qib7 9541 12 and and CC cord-005453-4057qib7 9541 13 once once RB cord-005453-4057qib7 9541 14 after after IN cord-005453-4057qib7 9541 15 RZF RZF NNP cord-005453-4057qib7 9541 16 administration administration NN cord-005453-4057qib7 9541 17 , , , cord-005453-4057qib7 9541 18 on on IN cord-005453-4057qib7 9541 19 a a DT cord-005453-4057qib7 9541 20 schedule schedule NN cord-005453-4057qib7 9541 21 designed design VBN cord-005453-4057qib7 9541 22 to to TO cord-005453-4057qib7 9541 23 allow allow VB cord-005453-4057qib7 9541 24 for for IN cord-005453-4057qib7 9541 25 washout washout NN cord-005453-4057qib7 9541 26 between between IN cord-005453-4057qib7 9541 27 doses dose NNS cord-005453-4057qib7 9541 28 and and CC cord-005453-4057qib7 9541 29 to to TO cord-005453-4057qib7 9541 30 limit limit VB cord-005453-4057qib7 9541 31 interactions interaction NNS cord-005453-4057qib7 9541 32 with with IN cord-005453-4057qib7 9541 33 other other JJ cord-005453-4057qib7 9541 34 probe probe NN cord-005453-4057qib7 9541 35 and and CC cord-005453-4057qib7 9541 36 test test NN cord-005453-4057qib7 9541 37 drugs drug NNS cord-005453-4057qib7 9541 38 . . . cord-005453-4057qib7 9542 1 Samples sample NNS cord-005453-4057qib7 9542 2 were be VBD cord-005453-4057qib7 9542 3 analysed analyse VBN cord-005453-4057qib7 9542 4 to to TO cord-005453-4057qib7 9542 5 determine determine VB cord-005453-4057qib7 9542 6 respective respective JJ cord-005453-4057qib7 9542 7 drug drug NN cord-005453-4057qib7 9542 8 concentrations concentration NNS cord-005453-4057qib7 9542 9 in in IN cord-005453-4057qib7 9542 10 plasma plasma NN cord-005453-4057qib7 9542 11 ( ( -LRB- cord-005453-4057qib7 9542 12 except except IN cord-005453-4057qib7 9542 13 for for IN cord-005453-4057qib7 9542 14 tacrolimus tacrolimus NN cord-005453-4057qib7 9542 15 which which WDT cord-005453-4057qib7 9542 16 was be VBD cord-005453-4057qib7 9542 17 in in IN cord-005453-4057qib7 9542 18 whole whole JJ cord-005453-4057qib7 9542 19 blood blood NN cord-005453-4057qib7 9542 20 ) ) -RRB- cord-005453-4057qib7 9542 21 to to TO cord-005453-4057qib7 9542 22 characterize characterize VB cord-005453-4057qib7 9542 23 the the DT cord-005453-4057qib7 9542 24 PK PK NNP cord-005453-4057qib7 9542 25 profile profile NN cord-005453-4057qib7 9542 26 of of IN cord-005453-4057qib7 9542 27 each each DT cord-005453-4057qib7 9542 28 analyte analyte NN cord-005453-4057qib7 9542 29 . . . cord-005453-4057qib7 9543 1 Area area NN cord-005453-4057qib7 9543 2 under under IN cord-005453-4057qib7 9543 3 curve curve NN cord-005453-4057qib7 9543 4 ( ( -LRB- cord-005453-4057qib7 9543 5 AUC AUC NNP cord-005453-4057qib7 9543 6 ) ) -RRB- cord-005453-4057qib7 9543 7 and and CC cord-005453-4057qib7 9543 8 maximum maximum JJ cord-005453-4057qib7 9543 9 concentration concentration NN cord-005453-4057qib7 9543 10 ( ( -LRB- cord-005453-4057qib7 9543 11 C C NNP cord-005453-4057qib7 9543 12 max max NNP cord-005453-4057qib7 9543 13 ) ) -RRB- cord-005453-4057qib7 9543 14 were be VBD cord-005453-4057qib7 9543 15 calculated calculate VBN cord-005453-4057qib7 9543 16 from from IN cord-005453-4057qib7 9543 17 the the DT cord-005453-4057qib7 9543 18 plasma plasma NN cord-005453-4057qib7 9543 19 / / SYM cord-005453-4057qib7 9543 20 blood blood NN cord-005453-4057qib7 9543 21 concentration concentration NN cord-005453-4057qib7 9543 22 - - HYPH cord-005453-4057qib7 9543 23 time time NN cord-005453-4057qib7 9543 24 profiles profile NNS cord-005453-4057qib7 9543 25 by by IN cord-005453-4057qib7 9543 26 noncompartmental noncompartmental JJ cord-005453-4057qib7 9543 27 analysis analysis NN cord-005453-4057qib7 9543 28 . . . cord-005453-4057qib7 9544 1 Ln ln NN cord-005453-4057qib7 9544 2 - - HYPH cord-005453-4057qib7 9544 3 transformed transform VBN cord-005453-4057qib7 9544 4 PK PK NNP cord-005453-4057qib7 9544 5 parameters parameter NNS cord-005453-4057qib7 9544 6 were be VBD cord-005453-4057qib7 9544 7 statistically statistically RB cord-005453-4057qib7 9544 8 analysed analyse VBN cord-005453-4057qib7 9544 9 using use VBG cord-005453-4057qib7 9544 10 an an DT cord-005453-4057qib7 9544 11 Analysis Analysis NNP cord-005453-4057qib7 9544 12 of of IN cord-005453-4057qib7 9544 13 Variance variance NN cord-005453-4057qib7 9544 14 model model NN cord-005453-4057qib7 9544 15 . . . cord-005453-4057qib7 9545 1 The the DT cord-005453-4057qib7 9545 2 ratio ratio NN cord-005453-4057qib7 9545 3 of of IN cord-005453-4057qib7 9545 4 geometric geometric JJ cord-005453-4057qib7 9545 5 least least JJS cord-005453-4057qib7 9545 6 squared squared JJ cord-005453-4057qib7 9545 7 means mean NNS cord-005453-4057qib7 9545 8 between between IN cord-005453-4057qib7 9545 9 each each DT cord-005453-4057qib7 9545 10 substrate substrate JJ cord-005453-4057qib7 9545 11 drug drug NN cord-005453-4057qib7 9545 12 when when WRB cord-005453-4057qib7 9545 13 administered administer VBN cord-005453-4057qib7 9545 14 with with IN cord-005453-4057qib7 9545 15 and and CC cord-005453-4057qib7 9545 16 without without IN cord-005453-4057qib7 9545 17 RZF RZF NNP cord-005453-4057qib7 9545 18 and and CC cord-005453-4057qib7 9545 19 corresponding correspond VBG cord-005453-4057qib7 9545 20 90 90 CD cord-005453-4057qib7 9545 21 % % NN cord-005453-4057qib7 9545 22 confidence confidence NN cord-005453-4057qib7 9545 23 intervals interval NNS cord-005453-4057qib7 9545 24 ( ( -LRB- cord-005453-4057qib7 9545 25 CIs CIs NNP cord-005453-4057qib7 9545 26 ) ) -RRB- cord-005453-4057qib7 9545 27 were be VBD cord-005453-4057qib7 9545 28 calculated calculate VBN cord-005453-4057qib7 9545 29 for for IN cord-005453-4057qib7 9545 30 lntransformed lntransformed NNP cord-005453-4057qib7 9545 31 C C NNP cord-005453-4057qib7 9545 32 max max NNP cord-005453-4057qib7 9545 33 and and CC cord-005453-4057qib7 9545 34 AUC AUC NNP cord-005453-4057qib7 9545 35 . . . cord-005453-4057qib7 9546 1 Results result NNS cord-005453-4057qib7 9546 2 : : : cord-005453-4057qib7 9547 1 When when WRB cord-005453-4057qib7 9547 2 RZF RZF NNP cord-005453-4057qib7 9547 3 was be VBD cord-005453-4057qib7 9547 4 given give VBN cord-005453-4057qib7 9547 5 concomitantly concomitantly RB cord-005453-4057qib7 9547 6 with with IN cord-005453-4057qib7 9547 7 the the DT cord-005453-4057qib7 9547 8 probe probe NN cord-005453-4057qib7 9547 9 drugs drug NNS cord-005453-4057qib7 9547 10 , , , cord-005453-4057qib7 9547 11 six six CD cord-005453-4057qib7 9547 12 of of IN cord-005453-4057qib7 9547 13 nine nine CD cord-005453-4057qib7 9547 14 substrates substrate NNS cord-005453-4057qib7 9547 15 ( ( -LRB- cord-005453-4057qib7 9547 16 metformin metformin NNP cord-005453-4057qib7 9547 17 , , , cord-005453-4057qib7 9547 18 pitavastatin pitavastatin NNP cord-005453-4057qib7 9547 19 , , , cord-005453-4057qib7 9547 20 caffeine caffeine NN cord-005453-4057qib7 9547 21 , , , cord-005453-4057qib7 9547 22 efavirenz efavirenz NNP cord-005453-4057qib7 9547 23 , , , cord-005453-4057qib7 9547 24 midazolam midazolam NN cord-005453-4057qib7 9547 25 , , , cord-005453-4057qib7 9547 26 and and CC cord-005453-4057qib7 9547 27 digoxin digoxin NN cord-005453-4057qib7 9547 28 ) ) -RRB- cord-005453-4057qib7 9547 29 statistically statistically RB cord-005453-4057qib7 9547 30 demonstrated demonstrate VBD cord-005453-4057qib7 9547 31 the the DT cord-005453-4057qib7 9547 32 absence absence NN cord-005453-4057qib7 9547 33 of of IN cord-005453-4057qib7 9547 34 drug drug NN cord-005453-4057qib7 9547 35 - - HYPH cord-005453-4057qib7 9547 36 drug drug NN cord-005453-4057qib7 9547 37 interaction interaction NN cord-005453-4057qib7 9547 38 , , , cord-005453-4057qib7 9547 39 as as IN cord-005453-4057qib7 9547 40 their -PRON- PRP$ cord-005453-4057qib7 9547 41 90 90 CD cord-005453-4057qib7 9547 42 % % NN cord-005453-4057qib7 9547 43 CI CI NNP cord-005453-4057qib7 9547 44 were be VBD cord-005453-4057qib7 9547 45 all all DT cord-005453-4057qib7 9547 46 included include VBN cord-005453-4057qib7 9547 47 within within IN cord-005453-4057qib7 9547 48 the the DT cord-005453-4057qib7 9547 49 default default NN cord-005453-4057qib7 9547 50 80 80 CD cord-005453-4057qib7 9547 51 - - SYM cord-005453-4057qib7 9547 52 125 125 CD cord-005453-4057qib7 9547 53 % % NN cord-005453-4057qib7 9547 54 noeffect noeffect NNP cord-005453-4057qib7 9547 55 boundary boundary NN cord-005453-4057qib7 9547 56 . . . cord-005453-4057qib7 9548 1 Three three CD cord-005453-4057qib7 9548 2 substrates substrate NNS cord-005453-4057qib7 9548 3 had have VBD cord-005453-4057qib7 9548 4 the the DT cord-005453-4057qib7 9548 5 upper upper JJ cord-005453-4057qib7 9548 6 ( ( -LRB- cord-005453-4057qib7 9548 7 repaglinide repaglinide NNP cord-005453-4057qib7 9548 8 and and CC cord-005453-4057qib7 9548 9 rosuvastatin rosuvastatin NNP cord-005453-4057qib7 9548 10 ) ) -RRB- cord-005453-4057qib7 9548 11 or or CC cord-005453-4057qib7 9548 12 lower low JJR cord-005453-4057qib7 9548 13 ( ( -LRB- cord-005453-4057qib7 9548 14 tacrolimus tacrolimus NNP cord-005453-4057qib7 9548 15 ) ) -RRB- cord-005453-4057qib7 9548 16 bounds bound NNS cord-005453-4057qib7 9548 17 of of IN cord-005453-4057qib7 9548 18 their -PRON- PRP$ cord-005453-4057qib7 9548 19 CI ci NN cord-005453-4057qib7 9548 20 falling fall VBG cord-005453-4057qib7 9548 21 just just RB cord-005453-4057qib7 9548 22 outside outside RB cord-005453-4057qib7 9548 23 of of IN cord-005453-4057qib7 9548 24 this this DT cord-005453-4057qib7 9548 25 range range NN cord-005453-4057qib7 9549 1 ( ( -LRB- cord-005453-4057qib7 9549 2 Figure figure NN cord-005453-4057qib7 9549 3 1 1 CD cord-005453-4057qib7 9549 4 ) ) -RRB- cord-005453-4057qib7 9549 5 , , , cord-005453-4057qib7 9549 6 and and CC cord-005453-4057qib7 9549 7 these these DT cord-005453-4057qib7 9549 8 changes change NNS cord-005453-4057qib7 9549 9 are be VBP cord-005453-4057qib7 9549 10 considered consider VBN cord-005453-4057qib7 9549 11 unlikely unlikely JJ cord-005453-4057qib7 9549 12 to to TO cord-005453-4057qib7 9549 13 be be VB cord-005453-4057qib7 9549 14 clinically clinically RB cord-005453-4057qib7 9549 15 significant significant JJ cord-005453-4057qib7 9549 16 . . . cord-005453-4057qib7 9550 1 Conclusions conclusion NNS cord-005453-4057qib7 9550 2 : : : cord-005453-4057qib7 9551 1 No no DT cord-005453-4057qib7 9551 2 meaningful meaningful JJ cord-005453-4057qib7 9551 3 PK PK NNP cord-005453-4057qib7 9551 4 interactions interaction NNS cord-005453-4057qib7 9551 5 were be VBD cord-005453-4057qib7 9551 6 observed observe VBN cord-005453-4057qib7 9551 7 between between IN cord-005453-4057qib7 9551 8 RZF RZF NNP cord-005453-4057qib7 9551 9 and and CC cord-005453-4057qib7 9551 10 9 9 CD cord-005453-4057qib7 9551 11 drugs drug NNS cord-005453-4057qib7 9551 12 known know VBN cord-005453-4057qib7 9551 13 to to TO cord-005453-4057qib7 9551 14 have have VB cord-005453-4057qib7 9551 15 DDIs ddi NNS cord-005453-4057qib7 9551 16 and/or and/or CC cord-005453-4057qib7 9551 17 likely likely JJ cord-005453-4057qib7 9551 18 to to TO cord-005453-4057qib7 9551 19 be be VB cord-005453-4057qib7 9551 20 coadministered coadministere VBN cord-005453-4057qib7 9551 21 with with IN cord-005453-4057qib7 9551 22 RZF RZF NNP cord-005453-4057qib7 9551 23 . . . cord-005453-4057qib7 9552 1 These these DT cord-005453-4057qib7 9552 2 findings finding NNS cord-005453-4057qib7 9552 3 provide provide VBP cord-005453-4057qib7 9552 4 evidence evidence NN cord-005453-4057qib7 9552 5 that that IN cord-005453-4057qib7 9552 6 no no DT cord-005453-4057qib7 9552 7 dose dose NN cord-005453-4057qib7 9552 8 adjustment adjustment NN cord-005453-4057qib7 9552 9 is be VBZ cord-005453-4057qib7 9552 10 expected expect VBN cord-005453-4057qib7 9552 11 when when WRB cord-005453-4057qib7 9552 12 RZF RZF NNP cord-005453-4057qib7 9552 13 is be VBZ cord-005453-4057qib7 9552 14 co co VBN cord-005453-4057qib7 9552 15 - - VBN cord-005453-4057qib7 9552 16 administered administer VBN cord-005453-4057qib7 9552 17 with with IN cord-005453-4057qib7 9552 18 these these DT cord-005453-4057qib7 9552 19 commonly commonly RB cord-005453-4057qib7 9552 20 used use VBN cord-005453-4057qib7 9552 21 drugs drug NNS cord-005453-4057qib7 9552 22 , , , cord-005453-4057qib7 9552 23 which which WDT cord-005453-4057qib7 9552 24 stand stand VBP cord-005453-4057qib7 9552 25 in in IN cord-005453-4057qib7 9552 26 contrast contrast NN cord-005453-4057qib7 9552 27 with with IN cord-005453-4057qib7 9552 28 the the DT cord-005453-4057qib7 9552 29 DDI DDI NNP cord-005453-4057qib7 9552 30 complications complication NNS cord-005453-4057qib7 9552 31 widely widely RB cord-005453-4057qib7 9552 32 associated associate VBN cord-005453-4057qib7 9552 33 with with IN cord-005453-4057qib7 9552 34 azole azole NNP cord-005453-4057qib7 9552 35 antifungals antifungal NNS cord-005453-4057qib7 9552 36 . . . cord-005453-4057qib7 9553 1 Disclosure disclosure NN cord-005453-4057qib7 9553 2 : : : cord-005453-4057qib7 9554 1 Voon Voon NNP cord-005453-4057qib7 9554 2 Ong Ong NNP cord-005453-4057qib7 9554 3 : : : cord-005453-4057qib7 9554 4 employee employee NN cord-005453-4057qib7 9554 5 , , , cord-005453-4057qib7 9554 6 stockholder stockholder NN cord-005453-4057qib7 9554 7 ( ( -LRB- cord-005453-4057qib7 9554 8 Cidara Cidara NNP cord-005453-4057qib7 9554 9 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9554 10 ) ) -RRB- cord-005453-4057qib7 9554 11 , , , cord-005453-4057qib7 9554 12 Michael Michael NNP cord-005453-4057qib7 9554 13 Boily Boily NNP cord-005453-4057qib7 9554 14 : : : cord-005453-4057qib7 9554 15 employee employee NN cord-005453-4057qib7 9554 16 ( ( -LRB- cord-005453-4057qib7 9554 17 Altasciences Altasciences NNP cord-005453-4057qib7 9554 18 ) ) -RRB- cord-005453-4057qib7 9554 19 , , , cord-005453-4057qib7 9554 20 Hong Hong NNP cord-005453-4057qib7 9554 21 Wong Wong NNP cord-005453-4057qib7 9554 22 : : : cord-005453-4057qib7 9554 23 employee employee NN cord-005453-4057qib7 9554 24 ( ( -LRB- cord-005453-4057qib7 9554 25 Altasciences Altasciences NNP cord-005453-4057qib7 9554 26 ) ) -RRB- cord-005453-4057qib7 9554 27 , , , cord-005453-4057qib7 9554 28 Taylor Taylor NNP cord-005453-4057qib7 9554 29 Sandison Sandison NNP cord-005453-4057qib7 9554 30 : : : cord-005453-4057qib7 9554 31 employee employee NN cord-005453-4057qib7 9554 32 , , , cord-005453-4057qib7 9554 33 stockholder stockholder NN cord-005453-4057qib7 9554 34 ( ( -LRB- cord-005453-4057qib7 9554 35 Cidara Cidara NNP cord-005453-4057qib7 9554 36 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9554 37 ) ) -RRB- cord-005453-4057qib7 9554 38 , , , cord-005453-4057qib7 9554 39 Shawn Shawn NNP cord-005453-4057qib7 9554 40 Flanagan Flanagan NNP cord-005453-4057qib7 9554 41 : : : cord-005453-4057qib7 9554 42 employee employee NN cord-005453-4057qib7 9554 43 , , , cord-005453-4057qib7 9554 44 stockholder stockholder NN cord-005453-4057qib7 9554 45 ( ( -LRB- cord-005453-4057qib7 9554 46 Cidara Cidara NNP cord-005453-4057qib7 9554 47 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9554 48 ) ) -RRB- cord-005453-4057qib7 9554 49 Abstract Abstract NNP cord-005453-4057qib7 9554 50 withdrawn withdraw VBN cord-005453-4057qib7 9554 51 . . . cord-005453-4057qib7 9555 1 Background background NN cord-005453-4057qib7 9555 2 : : : cord-005453-4057qib7 9555 3 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 9555 4 ( ( -LRB- cord-005453-4057qib7 9555 5 CMV CMV NNP cord-005453-4057qib7 9555 6 ) ) -RRB- cord-005453-4057qib7 9555 7 continues continue VBZ cord-005453-4057qib7 9555 8 to to TO cord-005453-4057qib7 9555 9 cause cause VB cord-005453-4057qib7 9555 10 morbidity morbidity NN cord-005453-4057qib7 9555 11 following following NN cord-005453-4057qib7 9555 12 allogeneic allogeneic NN cord-005453-4057qib7 9555 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 9555 14 stem stem NN cord-005453-4057qib7 9555 15 cell cell NN cord-005453-4057qib7 9555 16 transplantation transplantation NN cord-005453-4057qib7 9555 17 ( ( -LRB- cord-005453-4057qib7 9555 18 HSCT HSCT NNP cord-005453-4057qib7 9555 19 ) ) -RRB- cord-005453-4057qib7 9555 20 . . . cord-005453-4057qib7 9556 1 Letermovir Letermovir NNP cord-005453-4057qib7 9556 2 is be VBZ cord-005453-4057qib7 9556 3 a a DT cord-005453-4057qib7 9556 4 newly newly RB cord-005453-4057qib7 9556 5 approved approve VBN cord-005453-4057qib7 9556 6 drug drug NN cord-005453-4057qib7 9556 7 for for IN cord-005453-4057qib7 9556 8 CMV CMV NNP cord-005453-4057qib7 9556 9 prophylaxis prophylaxis NN cord-005453-4057qib7 9556 10 in in IN cord-005453-4057qib7 9556 11 CMV CMV NNP cord-005453-4057qib7 9556 12 - - HYPH cord-005453-4057qib7 9556 13 seropositive seropositive JJ cord-005453-4057qib7 9556 14 allogeneic allogeneic IN cord-005453-4057qib7 9556 15 HSCT HSCT NNP cord-005453-4057qib7 9556 16 recipients recipient NNS cord-005453-4057qib7 9556 17 . . . cord-005453-4057qib7 9557 1 However however RB cord-005453-4057qib7 9557 2 , , , cord-005453-4057qib7 9557 3 there there EX cord-005453-4057qib7 9557 4 is be VBZ cord-005453-4057qib7 9557 5 a a DT cord-005453-4057qib7 9557 6 paucity paucity NN cord-005453-4057qib7 9557 7 of of IN cord-005453-4057qib7 9557 8 data datum NNS cord-005453-4057qib7 9557 9 for for IN cord-005453-4057qib7 9557 10 its -PRON- PRP$ cord-005453-4057qib7 9557 11 efficacy efficacy NN cord-005453-4057qib7 9557 12 in in IN cord-005453-4057qib7 9557 13 patients patient NNS cord-005453-4057qib7 9557 14 receiving receive VBG cord-005453-4057qib7 9557 15 in in IN cord-005453-4057qib7 9557 16 - - HYPH cord-005453-4057qib7 9557 17 vivo vivo NN cord-005453-4057qib7 9557 18 T t NN cord-005453-4057qib7 9557 19 - - HYPH cord-005453-4057qib7 9557 20 cell cell NN cord-005453-4057qib7 9557 21 depletion depletion NN cord-005453-4057qib7 9557 22 ( ( -LRB- cord-005453-4057qib7 9557 23 TCD TCD NNP cord-005453-4057qib7 9557 24 ) ) -RRB- cord-005453-4057qib7 9557 25 . . . cord-005453-4057qib7 9558 1 At at IN cord-005453-4057qib7 9558 2 Weill Weill NNP cord-005453-4057qib7 9558 3 Cornell Cornell NNP cord-005453-4057qib7 9558 4 Medical Medical NNP cord-005453-4057qib7 9558 5 Center Center NNP cord-005453-4057qib7 9558 6 , , , cord-005453-4057qib7 9558 7 we -PRON- PRP cord-005453-4057qib7 9558 8 perform perform VBP cord-005453-4057qib7 9558 9 in in IN cord-005453-4057qib7 9558 10 - - HYPH cord-005453-4057qib7 9558 11 vivo vivo NN cord-005453-4057qib7 9558 12 TCD tcd NN cord-005453-4057qib7 9558 13 with with IN cord-005453-4057qib7 9558 14 alemtuzumab alemtuzumab NNS cord-005453-4057qib7 9558 15 for for IN cord-005453-4057qib7 9558 16 related related JJ cord-005453-4057qib7 9558 17 and and CC cord-005453-4057qib7 9558 18 HLA HLA NNP cord-005453-4057qib7 9558 19 - - HYPH cord-005453-4057qib7 9558 20 identical identical JJ cord-005453-4057qib7 9558 21 unrelated unrelated JJ cord-005453-4057qib7 9558 22 transplants transplant NNS cord-005453-4057qib7 9558 23 , , , cord-005453-4057qib7 9558 24 and and CC cord-005453-4057qib7 9558 25 anti anti JJ cord-005453-4057qib7 9558 26 - - JJ cord-005453-4057qib7 9558 27 thymocyte thymocyte JJ cord-005453-4057qib7 9558 28 globulin globulin NN cord-005453-4057qib7 9558 29 for for IN cord-005453-4057qib7 9558 30 umbilical umbilical JJ cord-005453-4057qib7 9558 31 cord cord NN cord-005453-4057qib7 9558 32 blood blood NN cord-005453-4057qib7 9558 33 transplant transplant NN cord-005453-4057qib7 9558 34 supported support VBN cord-005453-4057qib7 9558 35 by by IN cord-005453-4057qib7 9558 36 third third JJ cord-005453-4057qib7 9558 37 party party NN cord-005453-4057qib7 9558 38 accessory accessory NN cord-005453-4057qib7 9558 39 cells cell NNS cord-005453-4057qib7 9558 40 ( ( -LRB- cord-005453-4057qib7 9559 1 haplo haplo NN cord-005453-4057qib7 9559 2 - - HYPH cord-005453-4057qib7 9559 3 cord cord NN cord-005453-4057qib7 9559 4 transplant).Although transplant).although NN cord-005453-4057qib7 9560 1 these these DT cord-005453-4057qib7 9560 2 drugs drug NNS cord-005453-4057qib7 9560 3 reduce reduce VBP cord-005453-4057qib7 9560 4 the the DT cord-005453-4057qib7 9560 5 frequency frequency NN cord-005453-4057qib7 9560 6 of of IN cord-005453-4057qib7 9560 7 Graft graft NN cord-005453-4057qib7 9560 8 - - HYPH cord-005453-4057qib7 9560 9 Versus Versus NNP cord-005453-4057qib7 9560 10 - - HYPH cord-005453-4057qib7 9560 11 Host Host NNP cord-005453-4057qib7 9560 12 - - HYPH cord-005453-4057qib7 9560 13 Disease Disease NNP cord-005453-4057qib7 9560 14 ( ( -LRB- cord-005453-4057qib7 9560 15 GVHD GVHD NNP cord-005453-4057qib7 9560 16 ) ) -RRB- cord-005453-4057qib7 9560 17 , , , cord-005453-4057qib7 9560 18 they -PRON- PRP cord-005453-4057qib7 9560 19 significantly significantly RB cord-005453-4057qib7 9560 20 delay delay VBP cord-005453-4057qib7 9560 21 T t NN cord-005453-4057qib7 9560 22 - - HYPH cord-005453-4057qib7 9560 23 cell cell NN cord-005453-4057qib7 9560 24 immune immune JJ cord-005453-4057qib7 9560 25 reconstitution reconstitution NN cord-005453-4057qib7 9560 26 post post NN cord-005453-4057qib7 9560 27 HSCT HSCT NNP cord-005453-4057qib7 9560 28 , , , cord-005453-4057qib7 9560 29 and and CC cord-005453-4057qib7 9560 30 may may MD cord-005453-4057qib7 9560 31 cause cause VB cord-005453-4057qib7 9560 32 higher high JJR cord-005453-4057qib7 9560 33 rates rate NNS cord-005453-4057qib7 9560 34 of of IN cord-005453-4057qib7 9560 35 CMV CMV NNP cord-005453-4057qib7 9560 36 reactivation reactivation NN cord-005453-4057qib7 9560 37 . . . cord-005453-4057qib7 9561 1 Our -PRON- PRP$ cord-005453-4057qib7 9561 2 historical historical JJ cord-005453-4057qib7 9561 3 rate rate NN cord-005453-4057qib7 9561 4 of of IN cord-005453-4057qib7 9561 5 CMV CMV NNP cord-005453-4057qib7 9561 6 reactivation reactivation NN cord-005453-4057qib7 9561 7 in in IN cord-005453-4057qib7 9561 8 CMV CMV NNP cord-005453-4057qib7 9561 9 seropositive seropositive JJ cord-005453-4057qib7 9561 10 recipients recipient NNS cord-005453-4057qib7 9561 11 receiving receive VBG cord-005453-4057qib7 9561 12 high high JJ cord-005453-4057qib7 9561 13 dose dose NN cord-005453-4057qib7 9561 14 valacyclovir valacyclovir NNP cord-005453-4057qib7 9561 15 prophylaxis prophylaxis NN cord-005453-4057qib7 9561 16 is be VBZ cord-005453-4057qib7 9561 17 approximately approximately RB cord-005453-4057qib7 9561 18 35 35 CD cord-005453-4057qib7 9561 19 % % NN cord-005453-4057qib7 9561 20 . . . cord-005453-4057qib7 9562 1 Therefore therefore RB cord-005453-4057qib7 9562 2 , , , cord-005453-4057qib7 9562 3 we -PRON- PRP cord-005453-4057qib7 9562 4 implemented implement VBD cord-005453-4057qib7 9562 5 letermovir letermovir NNS cord-005453-4057qib7 9562 6 for for IN cord-005453-4057qib7 9562 7 CMV CMV NNP cord-005453-4057qib7 9562 8 prophylaxis prophylaxis NN cord-005453-4057qib7 9562 9 in in IN cord-005453-4057qib7 9562 10 February February NNP cord-005453-4057qib7 9562 11 2018 2018 CD cord-005453-4057qib7 9562 12 . . . cord-005453-4057qib7 9563 1 The the DT cord-005453-4057qib7 9563 2 primary primary JJ cord-005453-4057qib7 9563 3 aim aim NN cord-005453-4057qib7 9563 4 of of IN cord-005453-4057qib7 9563 5 this this DT cord-005453-4057qib7 9563 6 study study NN cord-005453-4057qib7 9563 7 is be VBZ cord-005453-4057qib7 9563 8 to to TO cord-005453-4057qib7 9563 9 determine determine VB cord-005453-4057qib7 9563 10 the the DT cord-005453-4057qib7 9563 11 incidence incidence NN cord-005453-4057qib7 9563 12 of of IN cord-005453-4057qib7 9563 13 CMV CMV NNP cord-005453-4057qib7 9563 14 infection infection NN cord-005453-4057qib7 9563 15 ( ( -LRB- cord-005453-4057qib7 9563 16 defined define VBN cord-005453-4057qib7 9563 17 as as IN cord-005453-4057qib7 9563 18 CMV CMV NNP cord-005453-4057qib7 9563 19 viremia viremia NN cord-005453-4057qib7 9563 20 warranting warrant VBG cord-005453-4057qib7 9563 21 treatment treatment NN cord-005453-4057qib7 9563 22 or or CC cord-005453-4057qib7 9563 23 development development NN cord-005453-4057qib7 9563 24 of of IN cord-005453-4057qib7 9563 25 end end NN cord-005453-4057qib7 9563 26 - - HYPH cord-005453-4057qib7 9563 27 organ organ NN cord-005453-4057qib7 9563 28 disease disease NN cord-005453-4057qib7 9563 29 ) ) -RRB- cord-005453-4057qib7 9563 30 in in IN cord-005453-4057qib7 9563 31 TCD TCD NNP cord-005453-4057qib7 9563 32 CMV CMV NNP cord-005453-4057qib7 9563 33 seropositive seropositive JJ cord-005453-4057qib7 9563 34 allogeneic allogeneic VBD cord-005453-4057qib7 9563 35 HSCT HSCT NNP cord-005453-4057qib7 9563 36 patients patient NNS cord-005453-4057qib7 9563 37 who who WP cord-005453-4057qib7 9563 38 received receive VBD cord-005453-4057qib7 9563 39 letermovir letermovir NNS cord-005453-4057qib7 9563 40 prophylaxis prophylaxis NN cord-005453-4057qib7 9563 41 . . . cord-005453-4057qib7 9564 1 Methods method NNS cord-005453-4057qib7 9564 2 : : : cord-005453-4057qib7 9564 3 This this DT cord-005453-4057qib7 9564 4 is be VBZ cord-005453-4057qib7 9564 5 a a DT cord-005453-4057qib7 9564 6 single single JJ cord-005453-4057qib7 9564 7 center center NN cord-005453-4057qib7 9564 8 , , , cord-005453-4057qib7 9564 9 retrospective retrospective JJ cord-005453-4057qib7 9564 10 cohort cohort NN cord-005453-4057qib7 9564 11 study study NN cord-005453-4057qib7 9564 12 to to TO cord-005453-4057qib7 9564 13 determine determine VB cord-005453-4057qib7 9564 14 the the DT cord-005453-4057qib7 9564 15 incidence incidence NN cord-005453-4057qib7 9564 16 of of IN cord-005453-4057qib7 9564 17 CMV CMV NNP cord-005453-4057qib7 9564 18 infection infection NN cord-005453-4057qib7 9564 19 in in IN cord-005453-4057qib7 9564 20 adult adult NN cord-005453-4057qib7 9564 21 , , , cord-005453-4057qib7 9564 22 CMV CMV NNP cord-005453-4057qib7 9564 23 - - HYPH cord-005453-4057qib7 9564 24 seropositive seropositive JJ cord-005453-4057qib7 9564 25 recipients recipient NNS cord-005453-4057qib7 9564 26 receiving receive VBG cord-005453-4057qib7 9564 27 letermovir letermovir NNS cord-005453-4057qib7 9564 28 prophylaxis prophylaxis NN cord-005453-4057qib7 9564 29 after after IN cord-005453-4057qib7 9564 30 in in IN cord-005453-4057qib7 9564 31 vivo vivo NNP cord-005453-4057qib7 9564 32 TCD TCD NNP cord-005453-4057qib7 9564 33 HSCT HSCT NNP cord-005453-4057qib7 9564 34 with with IN cord-005453-4057qib7 9564 35 ATG ATG NNP cord-005453-4057qib7 9564 36 or or CC cord-005453-4057qib7 9564 37 alemtuzumab alemtuzumab VBN cord-005453-4057qib7 9564 38 for for IN cord-005453-4057qib7 9564 39 GVHD GVHD NNP cord-005453-4057qib7 9564 40 prophylaxis prophylaxis NN cord-005453-4057qib7 9564 41 . . . cord-005453-4057qib7 9565 1 All all DT cord-005453-4057qib7 9565 2 included include VBN cord-005453-4057qib7 9565 3 subjects subject NNS cord-005453-4057qib7 9565 4 were be VBD cord-005453-4057qib7 9565 5 at at RB cord-005453-4057qib7 9565 6 least least RBS cord-005453-4057qib7 9565 7 100 100 CD cord-005453-4057qib7 9565 8 days day NNS cord-005453-4057qib7 9565 9 post post NN cord-005453-4057qib7 9565 10 - - NN cord-005453-4057qib7 9565 11 transplant transplant NN cord-005453-4057qib7 9565 12 . . . cord-005453-4057qib7 9566 1 Results result NNS cord-005453-4057qib7 9566 2 : : : cord-005453-4057qib7 9567 1 31 31 CD cord-005453-4057qib7 9567 2 allogeneic allogeneic NN cord-005453-4057qib7 9567 3 HSCT HSCT NNP cord-005453-4057qib7 9567 4 transplant transplant NN cord-005453-4057qib7 9567 5 recipients recipient NNS cord-005453-4057qib7 9567 6 met meet VBD cord-005453-4057qib7 9567 7 inclusion inclusion NN cord-005453-4057qib7 9567 8 criteria criterion NNS cord-005453-4057qib7 9567 9 . . . cord-005453-4057qib7 9568 1 Median median JJ cord-005453-4057qib7 9568 2 age age NN cord-005453-4057qib7 9568 3 was be VBD cord-005453-4057qib7 9568 4 60 60 CD cord-005453-4057qib7 9568 5 years year NNS cord-005453-4057qib7 9568 6 , , , cord-005453-4057qib7 9568 7 IQR IQR NNP cord-005453-4057qib7 9568 8 [ [ -LRB- cord-005453-4057qib7 9568 9 47 47 CD cord-005453-4057qib7 9568 10 , , , cord-005453-4057qib7 9568 11 67 67 CD cord-005453-4057qib7 9568 12 ] ] -RRB- cord-005453-4057qib7 9568 13 and and CC cord-005453-4057qib7 9568 14 48 48 CD cord-005453-4057qib7 9568 15 % % NN cord-005453-4057qib7 9568 16 were be VBD cord-005453-4057qib7 9568 17 male male JJ cord-005453-4057qib7 9568 18 . . . cord-005453-4057qib7 9569 1 Eight eight CD cord-005453-4057qib7 9569 2 ( ( -LRB- cord-005453-4057qib7 9569 3 26 26 CD cord-005453-4057qib7 9569 4 % % NN cord-005453-4057qib7 9569 5 ) ) -RRB- cord-005453-4057qib7 9569 6 had have VBD cord-005453-4057qib7 9569 7 a a DT cord-005453-4057qib7 9569 8 matched match VBN cord-005453-4057qib7 9569 9 related related JJ cord-005453-4057qib7 9569 10 donor donor NN cord-005453-4057qib7 9569 11 , , , cord-005453-4057qib7 9569 12 six six CD cord-005453-4057qib7 9569 13 ( ( -LRB- cord-005453-4057qib7 9569 14 19 19 CD cord-005453-4057qib7 9569 15 % % NN cord-005453-4057qib7 9569 16 ) ) -RRB- cord-005453-4057qib7 9569 17 had have VBD cord-005453-4057qib7 9569 18 a a DT cord-005453-4057qib7 9569 19 matched match VBN cord-005453-4057qib7 9569 20 unrelated unrelated JJ cord-005453-4057qib7 9569 21 donor donor NN cord-005453-4057qib7 9569 22 , , , cord-005453-4057qib7 9569 23 and and CC cord-005453-4057qib7 9569 24 17 17 CD cord-005453-4057qib7 9569 25 ( ( -LRB- cord-005453-4057qib7 9569 26 55 55 CD cord-005453-4057qib7 9569 27 % % NN cord-005453-4057qib7 9569 28 ) ) -RRB- cord-005453-4057qib7 9569 29 were be VBD cord-005453-4057qib7 9569 30 haplo haplo NN cord-005453-4057qib7 9569 31 - - HYPH cord-005453-4057qib7 9569 32 cord cord NN cord-005453-4057qib7 9569 33 transplants transplant NNS cord-005453-4057qib7 9569 34 . . . cord-005453-4057qib7 9570 1 Their -PRON- PRP$ cord-005453-4057qib7 9570 2 underlying underlying JJ cord-005453-4057qib7 9570 3 malignancy malignancy NN cord-005453-4057qib7 9570 4 and and CC cord-005453-4057qib7 9570 5 conditioning conditioning NN cord-005453-4057qib7 9570 6 regimens regimen NNS cord-005453-4057qib7 9570 7 are be VBP cord-005453-4057qib7 9570 8 summarized summarize VBN cord-005453-4057qib7 9570 9 in in IN cord-005453-4057qib7 9570 10 Table Table NNP cord-005453-4057qib7 9570 11 1 1 CD cord-005453-4057qib7 9570 12 . . . cord-005453-4057qib7 9571 1 17 17 CD cord-005453-4057qib7 9571 2 ( ( -LRB- cord-005453-4057qib7 9571 3 55 55 CD cord-005453-4057qib7 9571 4 % % NN cord-005453-4057qib7 9571 5 ) ) -RRB- cord-005453-4057qib7 9571 6 received receive VBD cord-005453-4057qib7 9571 7 ATG ATG NNP cord-005453-4057qib7 9571 8 and and CC cord-005453-4057qib7 9571 9 14 14 CD cord-005453-4057qib7 9571 10 ( ( -LRB- cord-005453-4057qib7 9571 11 45 45 CD cord-005453-4057qib7 9571 12 % % NN cord-005453-4057qib7 9571 13 ) ) -RRB- cord-005453-4057qib7 9571 14 received receive VBD cord-005453-4057qib7 9571 15 alemtuzumab alemtuzumab NNS cord-005453-4057qib7 9571 16 for for IN cord-005453-4057qib7 9571 17 GVHD GVHD NNP cord-005453-4057qib7 9571 18 prophylaxis prophylaxis NN cord-005453-4057qib7 9571 19 . . . cord-005453-4057qib7 9572 1 Median median JJ cord-005453-4057qib7 9572 2 follow follow VBP cord-005453-4057qib7 9572 3 up up RP cord-005453-4057qib7 9572 4 time time NN cord-005453-4057qib7 9572 5 for for IN cord-005453-4057qib7 9572 6 survivors survivor NNS cord-005453-4057qib7 9572 7 is be VBZ cord-005453-4057qib7 9572 8 141 141 CD cord-005453-4057qib7 9572 9 days day NNS cord-005453-4057qib7 9572 10 , , , cord-005453-4057qib7 9572 11 IQR IQR NNP cord-005453-4057qib7 9572 12 [ [ -LRB- cord-005453-4057qib7 9572 13 107 107 CD cord-005453-4057qib7 9572 14 , , , cord-005453-4057qib7 9572 15 187 187 CD cord-005453-4057qib7 9572 16 ] ] -RRB- cord-005453-4057qib7 9572 17 . . . cord-005453-4057qib7 9573 1 The the DT cord-005453-4057qib7 9573 2 incidence incidence NN cord-005453-4057qib7 9573 3 of of IN cord-005453-4057qib7 9573 4 CMV CMV NNP cord-005453-4057qib7 9573 5 infection infection NN cord-005453-4057qib7 9573 6 in in IN cord-005453-4057qib7 9573 7 the the DT cord-005453-4057qib7 9573 8 first first JJ cord-005453-4057qib7 9573 9 100 100 CD cord-005453-4057qib7 9573 10 days day NNS cord-005453-4057qib7 9573 11 post post NN cord-005453-4057qib7 9573 12 - - NN cord-005453-4057qib7 9573 13 transplant transplant NN cord-005453-4057qib7 9573 14 was be VBD cord-005453-4057qib7 9573 15 3 3 CD cord-005453-4057qib7 9573 16 % % NN cord-005453-4057qib7 9573 17 as as IN cord-005453-4057qib7 9573 18 only only RB cord-005453-4057qib7 9573 19 one one CD cord-005453-4057qib7 9573 20 patient patient NN cord-005453-4057qib7 9573 21 reactivated reactivate VBN cord-005453-4057qib7 9573 22 with with IN cord-005453-4057qib7 9573 23 detectable detectable JJ cord-005453-4057qib7 9573 24 CMV CMV NNP cord-005453-4057qib7 9573 25 viremia viremia NN cord-005453-4057qib7 9573 26 . . . cord-005453-4057qib7 9574 1 This this DT cord-005453-4057qib7 9574 2 same same JJ cord-005453-4057qib7 9574 3 patient patient NN cord-005453-4057qib7 9574 4 developed develop VBD cord-005453-4057qib7 9574 5 CMV CMV NNP cord-005453-4057qib7 9574 6 pneumonitis pneumonitis NN cord-005453-4057qib7 9574 7 with with IN cord-005453-4057qib7 9574 8 documented document VBN cord-005453-4057qib7 9574 9 UL ul NN cord-005453-4057qib7 9574 10 56 56 CD cord-005453-4057qib7 9574 11 resistance resistance NN cord-005453-4057qib7 9574 12 , , , cord-005453-4057qib7 9574 13 and and CC cord-005453-4057qib7 9574 14 was be VBD cord-005453-4057qib7 9574 15 successfully successfully RB cord-005453-4057qib7 9574 16 treated treat VBN cord-005453-4057qib7 9574 17 with with IN cord-005453-4057qib7 9574 18 ganciclovir ganciclovir NNS cord-005453-4057qib7 9574 19 . . . cord-005453-4057qib7 9575 1 The the DT cord-005453-4057qib7 9575 2 incidence incidence NN cord-005453-4057qib7 9575 3 of of IN cord-005453-4057qib7 9575 4 CMV CMV NNP cord-005453-4057qib7 9575 5 infection infection NN cord-005453-4057qib7 9575 6 within within IN cord-005453-4057qib7 9575 7 the the DT cord-005453-4057qib7 9575 8 first first JJ cord-005453-4057qib7 9575 9 150 150 CD cord-005453-4057qib7 9575 10 days day NNS cord-005453-4057qib7 9575 11 post post NN cord-005453-4057qib7 9575 12 - - NN cord-005453-4057qib7 9575 13 transplant transplant NN cord-005453-4057qib7 9575 14 was be VBD cord-005453-4057qib7 9575 15 5 5 CD cord-005453-4057qib7 9575 16 % % NN cord-005453-4057qib7 9575 17 ( ( -LRB- cord-005453-4057qib7 9575 18 1/19 1/19 CD cord-005453-4057qib7 9575 19 patients patient NNS cord-005453-4057qib7 9575 20 ) ) -RRB- cord-005453-4057qib7 9575 21 . . . cord-005453-4057qib7 9576 1 Six six CD cord-005453-4057qib7 9576 2 patients patient NNS cord-005453-4057qib7 9576 3 ( ( -LRB- cord-005453-4057qib7 9576 4 19 19 CD cord-005453-4057qib7 9576 5 % % NN cord-005453-4057qib7 9576 6 ) ) -RRB- cord-005453-4057qib7 9576 7 developed develop VBN cord-005453-4057qib7 9576 8 acute acute JJ cord-005453-4057qib7 9576 9 GVHD GVHD NNP cord-005453-4057qib7 9576 10 in in IN cord-005453-4057qib7 9576 11 the the DT cord-005453-4057qib7 9576 12 first first JJ cord-005453-4057qib7 9576 13 100 100 CD cord-005453-4057qib7 9576 14 days day NNS cord-005453-4057qib7 9576 15 , , , cord-005453-4057qib7 9576 16 and and CC cord-005453-4057qib7 9576 17 one one NN cord-005453-4057qib7 9576 18 ( ( -LRB- cord-005453-4057qib7 9576 19 3 3 CD cord-005453-4057qib7 9576 20 % % NN cord-005453-4057qib7 9576 21 ) ) -RRB- cord-005453-4057qib7 9576 22 had have VBD cord-005453-4057qib7 9576 23 relapse relapse NN cord-005453-4057qib7 9576 24 of of IN cord-005453-4057qib7 9576 25 their -PRON- PRP$ cord-005453-4057qib7 9576 26 malignancy malignancy NN cord-005453-4057qib7 9576 27 . . . cord-005453-4057qib7 9577 1 Five five CD cord-005453-4057qib7 9577 2 patients patient NNS cord-005453-4057qib7 9577 3 ( ( -LRB- cord-005453-4057qib7 9577 4 16 16 CD cord-005453-4057qib7 9577 5 % % NN cord-005453-4057qib7 9577 6 ) ) -RRB- cord-005453-4057qib7 9577 7 died die VBD cord-005453-4057qib7 9577 8 within within IN cord-005453-4057qib7 9577 9 100 100 CD cord-005453-4057qib7 9577 10 days day NNS cord-005453-4057qib7 9577 11 post post NN cord-005453-4057qib7 9577 12 - - NN cord-005453-4057qib7 9577 13 transplant transplant NN cord-005453-4057qib7 9577 14 , , , cord-005453-4057qib7 9577 15 but but CC cord-005453-4057qib7 9577 16 none none NN cord-005453-4057qib7 9577 17 of of IN cord-005453-4057qib7 9577 18 these these DT cord-005453-4057qib7 9577 19 deaths death NNS cord-005453-4057qib7 9577 20 were be VBD cord-005453-4057qib7 9577 21 CMV CMV NNP cord-005453-4057qib7 9577 22 related relate VBN cord-005453-4057qib7 9577 23 . . . cord-005453-4057qib7 9578 1 Background background NN cord-005453-4057qib7 9578 2 : : : cord-005453-4057qib7 9579 1 Infectious infectious JJ cord-005453-4057qib7 9579 2 complications complication NNS cord-005453-4057qib7 9579 3 caused cause VBN cord-005453-4057qib7 9579 4 by by IN cord-005453-4057qib7 9579 5 endogenous endogenous JJ cord-005453-4057qib7 9579 6 adenovirus adenovirus NN cord-005453-4057qib7 9579 7 ( ( -LRB- cord-005453-4057qib7 9579 8 AdV adv NN cord-005453-4057qib7 9579 9 ) ) -RRB- cord-005453-4057qib7 9579 10 are be VBP cord-005453-4057qib7 9579 11 common common JJ cord-005453-4057qib7 9579 12 and and CC cord-005453-4057qib7 9579 13 associated associate VBN cord-005453-4057qib7 9579 14 with with IN cord-005453-4057qib7 9579 15 morbidity morbidity NN cord-005453-4057qib7 9579 16 and and CC cord-005453-4057qib7 9579 17 mortality mortality NN cord-005453-4057qib7 9579 18 rates rate NNS cord-005453-4057qib7 9579 19 in in IN cord-005453-4057qib7 9579 20 patients patient NNS cord-005453-4057qib7 9579 21 after after IN cord-005453-4057qib7 9579 22 hematopoietic hematopoietic JJ cord-005453-4057qib7 9579 23 stem stem NN cord-005453-4057qib7 9579 24 cell cell NN cord-005453-4057qib7 9579 25 transplantation transplantation NN cord-005453-4057qib7 9579 26 ( ( -LRB- cord-005453-4057qib7 9579 27 HSCT HSCT NNP cord-005453-4057qib7 9579 28 ) ) -RRB- cord-005453-4057qib7 9579 29 . . . cord-005453-4057qib7 9580 1 AdV adv NN cord-005453-4057qib7 9580 2 infections infection NNS cord-005453-4057qib7 9580 3 occur occur VBP cord-005453-4057qib7 9580 4 in in IN cord-005453-4057qib7 9580 5 about about RB cord-005453-4057qib7 9580 6 3 3 CD cord-005453-4057qib7 9580 7 % % NN cord-005453-4057qib7 9580 8 to to TO cord-005453-4057qib7 9580 9 20 20 CD cord-005453-4057qib7 9580 10 % % NN cord-005453-4057qib7 9580 11 of of IN cord-005453-4057qib7 9580 12 HSCT HSCT NNP cord-005453-4057qib7 9580 13 recipients recipient NNS cord-005453-4057qib7 9580 14 , , , cord-005453-4057qib7 9580 15 with with IN cord-005453-4057qib7 9580 16 significantly significantly RB cord-005453-4057qib7 9580 17 higher high JJR cord-005453-4057qib7 9580 18 rates rate NNS cord-005453-4057qib7 9580 19 in in IN cord-005453-4057qib7 9580 20 pediatric pediatric JJ cord-005453-4057qib7 9580 21 patients patient NNS cord-005453-4057qib7 9580 22 . . . cord-005453-4057qib7 9581 1 A a DT cord-005453-4057qib7 9581 2 better well JJR cord-005453-4057qib7 9581 3 understanding understanding NN cord-005453-4057qib7 9581 4 of of IN cord-005453-4057qib7 9581 5 adenoviral adenoviral JJ cord-005453-4057qib7 9581 6 - - HYPH cord-005453-4057qib7 9581 7 specific specific JJ cord-005453-4057qib7 9581 8 T t NN cord-005453-4057qib7 9581 9 - - HYPH cord-005453-4057qib7 9581 10 cells cell NNS cord-005453-4057qib7 9581 11 ( ( -LRB- cord-005453-4057qib7 9581 12 AdvT AdvT NNP cord-005453-4057qib7 9581 13 ) ) -RRB- cord-005453-4057qib7 9581 14 response response NN cord-005453-4057qib7 9581 15 in in IN cord-005453-4057qib7 9581 16 donors donor NNS cord-005453-4057qib7 9581 17 can can MD cord-005453-4057qib7 9581 18 serve serve VB cord-005453-4057qib7 9581 19 as as IN cord-005453-4057qib7 9581 20 a a DT cord-005453-4057qib7 9581 21 basis basis NN cord-005453-4057qib7 9581 22 to to TO cord-005453-4057qib7 9581 23 develop develop VB cord-005453-4057qib7 9581 24 more more JJR cord-005453-4057qib7 9581 25 effective effective JJ cord-005453-4057qib7 9581 26 strategies strategy NNS cord-005453-4057qib7 9581 27 for for IN cord-005453-4057qib7 9581 28 antiviral antiviral JJ cord-005453-4057qib7 9581 29 therapy therapy NN cord-005453-4057qib7 9581 30 . . . cord-005453-4057qib7 9582 1 Methods method NNS cord-005453-4057qib7 9582 2 : : : cord-005453-4057qib7 9582 3 Frequencies frequency NNS cord-005453-4057qib7 9582 4 of of IN cord-005453-4057qib7 9582 5 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 9582 6 ( ( -LRB- cord-005453-4057qib7 9582 7 CMV)-and cmv)-and JJ cord-005453-4057qib7 9582 8 AdV adv NN cord-005453-4057qib7 9582 9 - - HYPH cord-005453-4057qib7 9582 10 specific specific JJ cord-005453-4057qib7 9582 11 T t NN cord-005453-4057qib7 9582 12 cells cell NNS cord-005453-4057qib7 9582 13 were be VBD cord-005453-4057qib7 9582 14 determined determine VBN cord-005453-4057qib7 9582 15 by by IN cord-005453-4057qib7 9582 16 enzyme enzyme NN cord-005453-4057qib7 9582 17 - - HYPH cord-005453-4057qib7 9582 18 linked link VBN cord-005453-4057qib7 9582 19 immunospot immunospot NNS cord-005453-4057qib7 9582 20 ( ( -LRB- cord-005453-4057qib7 9582 21 ELISPOT ELISPOT NNP cord-005453-4057qib7 9582 22 ) ) -RRB- cord-005453-4057qib7 9582 23 assays assays RB cord-005453-4057qib7 9582 24 with with IN cord-005453-4057qib7 9582 25 AdV5 AdV5 JJR cord-005453-4057qib7 9582 26 Hexon Hexon NNP cord-005453-4057qib7 9582 27 and and CC cord-005453-4057qib7 9582 28 CMVpp65 CMVpp65 NNP cord-005453-4057qib7 9582 29 respectively respectively RB cord-005453-4057qib7 9582 30 in in IN cord-005453-4057qib7 9582 31 80 80 CD cord-005453-4057qib7 9582 32 health health NN cord-005453-4057qib7 9582 33 donors donor NNS cord-005453-4057qib7 9582 34 . . . cord-005453-4057qib7 9583 1 We -PRON- PRP cord-005453-4057qib7 9583 2 used use VBD cord-005453-4057qib7 9583 3 3x10 3x10 CD cord-005453-4057qib7 9583 4 5 5 CD cord-005453-4057qib7 9583 5 of of IN cord-005453-4057qib7 9583 6 mononuclear mononuclear JJ cord-005453-4057qib7 9583 7 cells cell NNS cord-005453-4057qib7 9583 8 ( ( -LRB- cord-005453-4057qib7 9583 9 MNC MNC NNP cord-005453-4057qib7 9583 10 ) ) -RRB- cord-005453-4057qib7 9583 11 per per RB cord-005453-4057qib7 9583 12 well well RB cord-005453-4057qib7 9583 13 in in IN cord-005453-4057qib7 9583 14 ELISPOT ELISPOT NNP cord-005453-4057qib7 9583 15 assays assay NNS cord-005453-4057qib7 9583 16 . . . cord-005453-4057qib7 9584 1 All all DT cord-005453-4057qib7 9584 2 donors donor NNS cord-005453-4057qib7 9584 3 were be VBD cord-005453-4057qib7 9584 4 divided divide VBN cord-005453-4057qib7 9584 5 into into IN cord-005453-4057qib7 9584 6 3 3 CD cord-005453-4057qib7 9584 7 groups group NNS cord-005453-4057qib7 9584 8 according accord VBG cord-005453-4057qib7 9584 9 to to IN cord-005453-4057qib7 9584 10 the the DT cord-005453-4057qib7 9584 11 number number NN cord-005453-4057qib7 9584 12 of of IN cord-005453-4057qib7 9584 13 spots spot NNS cord-005453-4057qib7 9584 14 per per IN cord-005453-4057qib7 9584 15 well well RB cord-005453-4057qib7 9584 16 ( ( -LRB- cord-005453-4057qib7 9584 17 SPW SPW NNP cord-005453-4057qib7 9584 18 ) ) -RRB- cord-005453-4057qib7 9584 19 as as IN cord-005453-4057qib7 9584 20 follows follow VBZ cord-005453-4057qib7 9584 21 : : : cord-005453-4057qib7 9584 22 high high JJ cord-005453-4057qib7 9584 23 responders responder NNS cord-005453-4057qib7 9584 24 ( ( -LRB- cord-005453-4057qib7 9584 25 HR HR NNP cord-005453-4057qib7 9584 26 ) ) -RRB- cord-005453-4057qib7 9584 27 ( ( -LRB- cord-005453-4057qib7 9584 28 ≥50 ≥50 DT cord-005453-4057qib7 9584 29 spots spot NNS cord-005453-4057qib7 9584 30 ; ; , cord-005453-4057qib7 9584 31 n=32 n=32 NNP cord-005453-4057qib7 9584 32 ) ) -RRB- cord-005453-4057qib7 9584 33 , , , cord-005453-4057qib7 9584 34 low low JJ cord-005453-4057qib7 9584 35 responders responder NNS cord-005453-4057qib7 9584 36 ( ( -LRB- cord-005453-4057qib7 9584 37 LR LR NNP cord-005453-4057qib7 9584 38 ) ) -RRB- cord-005453-4057qib7 9584 39 ( ( -LRB- cord-005453-4057qib7 9584 40 > > NFP cord-005453-4057qib7 9584 41 10 10 CD cord-005453-4057qib7 9584 42 and and CC cord-005453-4057qib7 9584 43 < < XX cord-005453-4057qib7 9584 44 50 50 CD cord-005453-4057qib7 9584 45 spots spot NNS cord-005453-4057qib7 9584 46 ; ; : cord-005453-4057qib7 9584 47 n=39 n=39 NNP cord-005453-4057qib7 9584 48 ) ) -RRB- cord-005453-4057qib7 9584 49 , , , cord-005453-4057qib7 9584 50 nonresponders nonresponders NNP cord-005453-4057qib7 9584 51 ( ( -LRB- cord-005453-4057qib7 9584 52 NR NR NNP cord-005453-4057qib7 9584 53 ) ) -RRB- cord-005453-4057qib7 9584 54 ( ( -LRB- cord-005453-4057qib7 9584 55 ≤10 ≤10 `` cord-005453-4057qib7 9584 56 spots spot NNS cord-005453-4057qib7 9584 57 ; ; : cord-005453-4057qib7 9584 58 n=9 n=9 NN cord-005453-4057qib7 9584 59 ) ) -RRB- cord-005453-4057qib7 9584 60 . . . cord-005453-4057qib7 9585 1 The the DT cord-005453-4057qib7 9585 2 average average JJ cord-005453-4057qib7 9585 3 spot spot NN cord-005453-4057qib7 9585 4 area area NN cord-005453-4057qib7 9585 5 of of IN cord-005453-4057qib7 9585 6 AdV adv NN cord-005453-4057qib7 9585 7 - - : cord-005453-4057qib7 9585 8 and and CC cord-005453-4057qib7 9585 9 CMV CMV NNP cord-005453-4057qib7 9585 10 - - HYPH cord-005453-4057qib7 9585 11 specific specific JJ cord-005453-4057qib7 9585 12 lymphocytes lymphocyte NNS cord-005453-4057qib7 9585 13 was be VBD cord-005453-4057qib7 9585 14 calculated calculate VBN cord-005453-4057qib7 9585 15 by by IN cord-005453-4057qib7 9585 16 ImmunoSpot ImmunoSpot NNP cord-005453-4057qib7 9585 17 ® ® POS cord-005453-4057qib7 9585 18 MultiPlate MultiPlate NNP cord-005453-4057qib7 9585 19 AutoCount AutoCount NNP cord-005453-4057qib7 9585 20 ™ ™ NN cord-005453-4057qib7 9585 21 . . . cord-005453-4057qib7 9586 1 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 9586 2 and and CC cord-005453-4057qib7 9586 3 CD45RO+ CD45RO+ NNP cord-005453-4057qib7 9586 4 T T NNP cord-005453-4057qib7 9586 5 - - HYPH cord-005453-4057qib7 9586 6 cells cell NNS cord-005453-4057qib7 9586 7 were be VBD cord-005453-4057qib7 9586 8 generated generate VBN cord-005453-4057qib7 9586 9 by by IN cord-005453-4057qib7 9586 10 immunomagnetic immunomagnetic JJ cord-005453-4057qib7 9586 11 negative negative JJ cord-005453-4057qib7 9586 12 selection selection NN cord-005453-4057qib7 9586 13 . . . cord-005453-4057qib7 9587 1 HLA HLA NNP cord-005453-4057qib7 9587 2 typing type VBG cord-005453-4057qib7 9587 3 for for IN cord-005453-4057qib7 9587 4 class class NN cord-005453-4057qib7 9588 1 I -PRON- PRP cord-005453-4057qib7 9588 2 and and CC cord-005453-4057qib7 9588 3 II II NNP cord-005453-4057qib7 9588 4 was be VBD cord-005453-4057qib7 9588 5 performed perform VBN cord-005453-4057qib7 9588 6 by by IN cord-005453-4057qib7 9588 7 Sequence Sequence NNP cord-005453-4057qib7 9588 8 Specific Specific NNP cord-005453-4057qib7 9588 9 Oligonucleotides Oligonucleotides NNP cord-005453-4057qib7 9588 10 technology technology NN cord-005453-4057qib7 9588 11 . . . cord-005453-4057qib7 9589 1 Statistical statistical JJ cord-005453-4057qib7 9589 2 analysis analysis NN cord-005453-4057qib7 9589 3 was be VBD cord-005453-4057qib7 9589 4 performed perform VBN cord-005453-4057qib7 9589 5 using use VBG cord-005453-4057qib7 9589 6 GraphPad GraphPad NNP cord-005453-4057qib7 9589 7 Prism Prism NNP cord-005453-4057qib7 9589 8 v7.00 v7.00 NN cord-005453-4057qib7 9589 9 software software NN cord-005453-4057qib7 9589 10 . . . cord-005453-4057qib7 9590 1 Levels level NNS cord-005453-4057qib7 9590 2 of of IN cord-005453-4057qib7 9590 3 significance significance NN cord-005453-4057qib7 9590 4 were be VBD cord-005453-4057qib7 9590 5 calculated calculate VBN cord-005453-4057qib7 9590 6 by by IN cord-005453-4057qib7 9590 7 Mann Mann NNP cord-005453-4057qib7 9590 8 - - HYPH cord-005453-4057qib7 9590 9 Whitney Whitney NNP cord-005453-4057qib7 9590 10 rank rank NN cord-005453-4057qib7 9590 11 - - HYPH cord-005453-4057qib7 9590 12 sum sum NN cord-005453-4057qib7 9590 13 test test NN cord-005453-4057qib7 9590 14 , , , cord-005453-4057qib7 9590 15 expressed express VBD cord-005453-4057qib7 9590 16 as as IN cord-005453-4057qib7 9590 17 p p NN cord-005453-4057qib7 9590 18 - - HYPH cord-005453-4057qib7 9590 19 values value NNS cord-005453-4057qib7 9590 20 ( ( -LRB- cord-005453-4057qib7 9590 21 p p NN cord-005453-4057qib7 9590 22 < < XX cord-005453-4057qib7 9590 23 0.05 0.05 CD cord-005453-4057qib7 9590 24 ) ) -RRB- cord-005453-4057qib7 9590 25 . . . cord-005453-4057qib7 9591 1 Results result NNS cord-005453-4057qib7 9591 2 : : : cord-005453-4057qib7 9592 1 The the DT cord-005453-4057qib7 9592 2 median median JJ cord-005453-4057qib7 9592 3 frequency frequency NN cord-005453-4057qib7 9592 4 per per IN cord-005453-4057qib7 9592 5 well well NN cord-005453-4057qib7 9592 6 of of IN cord-005453-4057qib7 9592 7 AdvTs AdvTs NNP cord-005453-4057qib7 9592 8 were be VBD cord-005453-4057qib7 9592 9 72 72 CD cord-005453-4057qib7 9592 10 in in IN cord-005453-4057qib7 9592 11 HR HR NNP cord-005453-4057qib7 9592 12 group group NN cord-005453-4057qib7 9592 13 , , , cord-005453-4057qib7 9592 14 24 24 CD cord-005453-4057qib7 9592 15 in in IN cord-005453-4057qib7 9592 16 LR LR NNP cord-005453-4057qib7 9592 17 group group NN cord-005453-4057qib7 9592 18 , , , cord-005453-4057qib7 9592 19 4 4 CD cord-005453-4057qib7 9592 20 in in IN cord-005453-4057qib7 9592 21 NR NR NNP cord-005453-4057qib7 9592 22 group group NN cord-005453-4057qib7 9592 23 . . . cord-005453-4057qib7 9593 1 The the DT cord-005453-4057qib7 9593 2 median median JJ cord-005453-4057qib7 9593 3 SPW SPW NNP cord-005453-4057qib7 9593 4 of of IN cord-005453-4057qib7 9593 5 CMV CMV NNP cord-005453-4057qib7 9593 6 - - HYPH cord-005453-4057qib7 9593 7 specific specific JJ cord-005453-4057qib7 9593 8 T T NNP cord-005453-4057qib7 9593 9 cells cell NNS cord-005453-4057qib7 9593 10 in in IN cord-005453-4057qib7 9593 11 donors donor NNS cord-005453-4057qib7 9594 1 MNC MNC NNP cord-005453-4057qib7 9594 2 were be VBD cord-005453-4057qib7 9594 3 147 147 CD cord-005453-4057qib7 9594 4 and and CC cord-005453-4057qib7 9594 5 didn´t didn´t TO cord-005453-4057qib7 9594 6 differ differ VB cord-005453-4057qib7 9594 7 between between IN cord-005453-4057qib7 9594 8 3 3 CD cord-005453-4057qib7 9594 9 groups group NNS cord-005453-4057qib7 9594 10 . . . cord-005453-4057qib7 9595 1 Antiviral antiviral JJ cord-005453-4057qib7 9595 2 activity activity NN cord-005453-4057qib7 9595 3 may may MD cord-005453-4057qib7 9595 4 depend depend VB cord-005453-4057qib7 9595 5 not not RB cord-005453-4057qib7 9595 6 only only RB cord-005453-4057qib7 9595 7 on on IN cord-005453-4057qib7 9595 8 the the DT cord-005453-4057qib7 9595 9 amount amount NN cord-005453-4057qib7 9595 10 of of IN cord-005453-4057qib7 9595 11 AdvT AdvT NNP cord-005453-4057qib7 9595 12 but but CC cord-005453-4057qib7 9595 13 also also RB cord-005453-4057qib7 9595 14 on on IN cord-005453-4057qib7 9595 15 their -PRON- PRP$ cord-005453-4057qib7 9595 16 ability ability NN cord-005453-4057qib7 9595 17 to to TO cord-005453-4057qib7 9595 18 produce produce VB cord-005453-4057qib7 9595 19 IFNγ IFNγ NNS cord-005453-4057qib7 9595 20 . . . cord-005453-4057qib7 9596 1 The the DT cord-005453-4057qib7 9596 2 average average JJ cord-005453-4057qib7 9596 3 spot spot NN cord-005453-4057qib7 9596 4 area area NN cord-005453-4057qib7 9596 5 for for IN cord-005453-4057qib7 9596 6 AdvT AdvT NNP cord-005453-4057qib7 9596 7 did do VBD cord-005453-4057qib7 9596 8 not not RB cord-005453-4057qib7 9596 9 differ differ VB cord-005453-4057qib7 9596 10 between between IN cord-005453-4057qib7 9596 11 HR hr NN cord-005453-4057qib7 9596 12 , , , cord-005453-4057qib7 9596 13 LR LR NNP cord-005453-4057qib7 9596 14 and and CC cord-005453-4057qib7 9596 15 NR NR NNP cord-005453-4057qib7 9596 16 groups group NNS cord-005453-4057qib7 9596 17 and and CC cord-005453-4057qib7 9596 18 were be VBD cord-005453-4057qib7 9596 19 22,4 22,4 CD cord-005453-4057qib7 9596 20 , , , cord-005453-4057qib7 9596 21 23,1 23,1 CD cord-005453-4057qib7 9596 22 and and CC cord-005453-4057qib7 9596 23 19,1 19,1 CD cord-005453-4057qib7 9596 24 mm mm CD cord-005453-4057qib7 9596 25 2 2 CD cord-005453-4057qib7 9596 26 respectively respectively RB cord-005453-4057qib7 9596 27 . . . cord-005453-4057qib7 9597 1 The the DT cord-005453-4057qib7 9597 2 median median NN cord-005453-4057qib7 9597 3 of of IN cord-005453-4057qib7 9597 4 the the DT cord-005453-4057qib7 9597 5 average average JJ cord-005453-4057qib7 9597 6 spot spot NN cord-005453-4057qib7 9597 7 area area NN cord-005453-4057qib7 9597 8 for for IN cord-005453-4057qib7 9597 9 anti anti JJ cord-005453-4057qib7 9597 10 - - JJ cord-005453-4057qib7 9597 11 CMV CMV NNP cord-005453-4057qib7 9597 12 T t NN cord-005453-4057qib7 9597 13 - - HYPH cord-005453-4057qib7 9597 14 lymphocytes lymphocyte NNS cord-005453-4057qib7 9597 15 was be VBD cord-005453-4057qib7 9597 16 equal equal JJ cord-005453-4057qib7 9597 17 to to IN cord-005453-4057qib7 9597 18 13,5 13,5 CD cord-005453-4057qib7 9597 19 mm mm CD cord-005453-4057qib7 9597 20 2 2 CD cord-005453-4057qib7 9597 21 . . . cord-005453-4057qib7 9598 1 Thus thus RB cord-005453-4057qib7 9598 2 , , , cord-005453-4057qib7 9598 3 the the DT cord-005453-4057qib7 9598 4 frequency frequency NN cord-005453-4057qib7 9598 5 of of IN cord-005453-4057qib7 9598 6 AdvT AdvT NNP cord-005453-4057qib7 9598 7 was be VBD cord-005453-4057qib7 9598 8 lower low JJR cord-005453-4057qib7 9598 9 than than IN cord-005453-4057qib7 9598 10 CMV CMV NNP cord-005453-4057qib7 9598 11 - - HYPH cord-005453-4057qib7 9598 12 specific specific JJ cord-005453-4057qib7 9598 13 T t NN cord-005453-4057qib7 9598 14 - - HYPH cord-005453-4057qib7 9598 15 cells cell NNS cord-005453-4057qib7 9598 16 , , , cord-005453-4057qib7 9598 17 but but CC cord-005453-4057qib7 9598 18 AdvT AdvT NNP cord-005453-4057qib7 9598 19 have have VB cord-005453-4057qib7 9598 20 the the DT cord-005453-4057qib7 9598 21 ability ability NN cord-005453-4057qib7 9598 22 to to TO cord-005453-4057qib7 9598 23 produce produce VB cord-005453-4057qib7 9598 24 more more JJR cord-005453-4057qib7 9598 25 IFNγ IFNγ NNS cord-005453-4057qib7 9598 26 per per IN cord-005453-4057qib7 9598 27 cell cell NN cord-005453-4057qib7 9598 28 ( ( -LRB- cord-005453-4057qib7 9598 29 p p NN cord-005453-4057qib7 9598 30 < < XX cord-005453-4057qib7 9598 31 0.0001 0.0001 CD cord-005453-4057qib7 9598 32 ) ) -RRB- cord-005453-4057qib7 9598 33 . . . cord-005453-4057qib7 9599 1 In in IN cord-005453-4057qib7 9599 2 order order NN cord-005453-4057qib7 9599 3 to to TO cord-005453-4057qib7 9599 4 evaluate evaluate VB cord-005453-4057qib7 9599 5 the the DT cord-005453-4057qib7 9599 6 distribution distribution NN cord-005453-4057qib7 9599 7 of of IN cord-005453-4057qib7 9599 8 the the DT cord-005453-4057qib7 9599 9 AdvT AdvT NNP cord-005453-4057qib7 9599 10 between between IN cord-005453-4057qib7 9599 11 naive naive JJ cord-005453-4057qib7 9599 12 and and CC cord-005453-4057qib7 9599 13 memory memory NN cord-005453-4057qib7 9599 14 T t NN cord-005453-4057qib7 9599 15 cell cell NN cord-005453-4057qib7 9599 16 compartments compartment NNS cord-005453-4057qib7 9599 17 , , , cord-005453-4057qib7 9599 18 we -PRON- PRP cord-005453-4057qib7 9599 19 evaluated evaluate VBD cord-005453-4057qib7 9599 20 response response NN cord-005453-4057qib7 9599 21 to to IN cord-005453-4057qib7 9599 22 AdV adv NN cord-005453-4057qib7 9599 23 in in IN cord-005453-4057qib7 9599 24 preselected preselected JJ cord-005453-4057qib7 9599 25 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 9599 26 and and CC cord-005453-4057qib7 9599 27 CD45RO+ CD45RO+ NNP cord-005453-4057qib7 9599 28 fractions fraction NNS cord-005453-4057qib7 9599 29 of of IN cord-005453-4057qib7 9599 30 T t NN cord-005453-4057qib7 9599 31 - - HYPH cord-005453-4057qib7 9599 32 cells cell NNS cord-005453-4057qib7 9599 33 in in IN cord-005453-4057qib7 9599 34 a a DT cord-005453-4057qib7 9599 35 group group NN cord-005453-4057qib7 9599 36 of of IN cord-005453-4057qib7 9599 37 17 17 CD cord-005453-4057qib7 9599 38 donors donor NNS cord-005453-4057qib7 9599 39 . . . cord-005453-4057qib7 9600 1 The the DT cord-005453-4057qib7 9600 2 median median JJ cord-005453-4057qib7 9600 3 frequency frequency NN cord-005453-4057qib7 9600 4 of of IN cord-005453-4057qib7 9600 5 AdvT AdvT NNP cord-005453-4057qib7 9600 6 in in IN cord-005453-4057qib7 9600 7 unfractionated unfractionated JJ cord-005453-4057qib7 9600 8 MNC MNC NNP cord-005453-4057qib7 9600 9 was be VBD cord-005453-4057qib7 9600 10 87 87 CD cord-005453-4057qib7 9600 11 ; ; : cord-005453-4057qib7 9600 12 the the DT cord-005453-4057qib7 9600 13 median median JJ cord-005453-4057qib7 9600 14 frequency frequency NN cord-005453-4057qib7 9600 15 of of IN cord-005453-4057qib7 9600 16 AdvT AdvT NNP cord-005453-4057qib7 9600 17 in in IN cord-005453-4057qib7 9600 18 CD45RA cd45ra NN cord-005453-4057qib7 9600 19 and and CC cord-005453-4057qib7 9600 20 CD45RO cd45ro JJ cord-005453-4057qib7 9600 21 fractions fraction NNS cord-005453-4057qib7 9600 22 were be VBD cord-005453-4057qib7 9600 23 2 2 CD cord-005453-4057qib7 9600 24 and and CC cord-005453-4057qib7 9600 25 73 73 CD cord-005453-4057qib7 9600 26 , , , cord-005453-4057qib7 9600 27 respectively respectively RB cord-005453-4057qib7 9600 28 . . . cord-005453-4057qib7 9601 1 The the DT cord-005453-4057qib7 9601 2 amounts amount NNS cord-005453-4057qib7 9601 3 of of IN cord-005453-4057qib7 9601 4 CD45RA cd45ra NN cord-005453-4057qib7 9601 5 and and CC cord-005453-4057qib7 9601 6 CD45RO CD45RO NNP cord-005453-4057qib7 9601 7 Tcells Tcells NNP cord-005453-4057qib7 9601 8 were be VBD cord-005453-4057qib7 9601 9 normalized normalize VBN cord-005453-4057qib7 9601 10 to to IN cord-005453-4057qib7 9601 11 their -PRON- PRP$ cord-005453-4057qib7 9601 12 amounts amount NNS cord-005453-4057qib7 9601 13 in in IN cord-005453-4057qib7 9601 14 MNC MNC NNP cord-005453-4057qib7 9601 15 . . . cord-005453-4057qib7 9602 1 We -PRON- PRP cord-005453-4057qib7 9602 2 evaluated evaluate VBD cord-005453-4057qib7 9602 3 the the DT cord-005453-4057qib7 9602 4 impact impact NN cord-005453-4057qib7 9602 5 of of IN cord-005453-4057qib7 9602 6 HLA HLA NNP cord-005453-4057qib7 9602 7 - - HYPH cord-005453-4057qib7 9602 8 alleles allele NNS cord-005453-4057qib7 9602 9 on on IN cord-005453-4057qib7 9602 10 the the DT cord-005453-4057qib7 9602 11 anti anti JJ cord-005453-4057qib7 9602 12 - - JJ cord-005453-4057qib7 9602 13 AdV adv JJ cord-005453-4057qib7 9602 14 response response NN cord-005453-4057qib7 9602 15 of of IN cord-005453-4057qib7 9602 16 T T NNP cord-005453-4057qib7 9602 17 - - HYPH cord-005453-4057qib7 9602 18 cells cell NNS cord-005453-4057qib7 9602 19 in in IN cord-005453-4057qib7 9602 20 different different JJ cord-005453-4057qib7 9602 21 groups group NNS cord-005453-4057qib7 9602 22 and and CC cord-005453-4057qib7 9602 23 found find VBD cord-005453-4057qib7 9602 24 2 2 CD cord-005453-4057qib7 9602 25 association association NN cord-005453-4057qib7 9602 26 : : : cord-005453-4057qib7 9602 27 HLA HLA NNP cord-005453-4057qib7 9602 28 - - HYPH cord-005453-4057qib7 9602 29 A*1 A*1 NNP cord-005453-4057qib7 9602 30 with with IN cord-005453-4057qib7 9602 31 HR hr NN cord-005453-4057qib7 9602 32 group group NN cord-005453-4057qib7 9602 33 ( ( -LRB- cord-005453-4057qib7 9602 34 P p NN cord-005453-4057qib7 9602 35 - - HYPH cord-005453-4057qib7 9602 36 value=0,0043 value=0,0043 NN cord-005453-4057qib7 9602 37 ; ; : cord-005453-4057qib7 9602 38 RR=1,954 rr=1,954 NN cord-005453-4057qib7 9602 39 ; ; : cord-005453-4057qib7 9602 40 95 95 CD cord-005453-4057qib7 9602 41 % % NN cord-005453-4057qib7 9602 42 CI ci NN cord-005453-4057qib7 9602 43 : : : cord-005453-4057qib7 9603 1 1,285 1,285 CD cord-005453-4057qib7 9603 2 to to IN cord-005453-4057qib7 9603 3 2,604 2,604 CD cord-005453-4057qib7 9603 4 ) ) -RRB- cord-005453-4057qib7 9603 5 and and CC cord-005453-4057qib7 9603 6 HLA HLA NNP cord-005453-4057qib7 9603 7 - - HYPH cord-005453-4057qib7 9603 8 A*31 A*31 NNP cord-005453-4057qib7 9603 9 with with IN cord-005453-4057qib7 9603 10 LR LR NNP cord-005453-4057qib7 9603 11 group group NN cord-005453-4057qib7 9603 12 0251 0251 CD cord-005453-4057qib7 9603 13 ; ; : cord-005453-4057qib7 9603 14 RR=1 RR=1 NNP cord-005453-4057qib7 9603 15 , , , cord-005453-4057qib7 9603 16 889 889 CD cord-005453-4057qib7 9603 17 ; ; : cord-005453-4057qib7 9603 18 95 95 CD cord-005453-4057qib7 9603 19 % % NN cord-005453-4057qib7 9603 20 CI ci NN cord-005453-4057qib7 9603 21 : : : cord-005453-4057qib7 9603 22 1 1 CD cord-005453-4057qib7 9603 23 , , , cord-005453-4057qib7 9603 24 135 135 CD cord-005453-4057qib7 9603 25 to to TO cord-005453-4057qib7 9603 26 4 4 CD cord-005453-4057qib7 9603 27 , , , cord-005453-4057qib7 9603 28 426 426 CD cord-005453-4057qib7 9603 29 ) ) -RRB- cord-005453-4057qib7 9603 30 . . . cord-005453-4057qib7 9604 1 Conclusions conclusion NNS cord-005453-4057qib7 9604 2 : : : cord-005453-4057qib7 9605 1 In in IN cord-005453-4057qib7 9605 2 this this DT cord-005453-4057qib7 9605 3 study study NN cord-005453-4057qib7 9605 4 the the DT cord-005453-4057qib7 9605 5 frequency frequency NN cord-005453-4057qib7 9605 6 of of IN cord-005453-4057qib7 9605 7 donors donor NNS cord-005453-4057qib7 9605 8 with with IN cord-005453-4057qib7 9605 9 AdvT AdvT NNP cord-005453-4057qib7 9605 10 is be VBZ cord-005453-4057qib7 9605 11 88,75 88,75 CD cord-005453-4057qib7 9605 12 % % NN cord-005453-4057qib7 9605 13 which which WDT cord-005453-4057qib7 9605 14 corresponds correspond VBZ cord-005453-4057qib7 9605 15 to to IN cord-005453-4057qib7 9605 16 the the DT cord-005453-4057qib7 9605 17 reported report VBN cord-005453-4057qib7 9605 18 frequency frequency NN cord-005453-4057qib7 9605 19 of of IN cord-005453-4057qib7 9605 20 AdV adv NN cord-005453-4057qib7 9605 21 - - HYPH cord-005453-4057qib7 9605 22 seropositive seropositive JJ cord-005453-4057qib7 9605 23 people people NNS cord-005453-4057qib7 9605 24 ( ( -LRB- cord-005453-4057qib7 9605 25 95 95 CD cord-005453-4057qib7 9605 26 % % NN cord-005453-4057qib7 9605 27 ) ) -RRB- cord-005453-4057qib7 9605 28 in in IN cord-005453-4057qib7 9605 29 population population NN cord-005453-4057qib7 9605 30 of of IN cord-005453-4057qib7 9605 31 Russia Russia NNP cord-005453-4057qib7 9605 32 . . . cord-005453-4057qib7 9606 1 AdvT AdvT NNP cord-005453-4057qib7 9606 2 are be VBP cord-005453-4057qib7 9606 3 exclusively exclusively RB cord-005453-4057qib7 9606 4 CD45RO cd45ro JJ cord-005453-4057qib7 9606 5 - - HYPH cord-005453-4057qib7 9606 6 positive positive JJ cord-005453-4057qib7 9606 7 cells cell NNS cord-005453-4057qib7 9606 8 . . . cord-005453-4057qib7 9607 1 The the DT cord-005453-4057qib7 9607 2 analysis analysis NN cord-005453-4057qib7 9607 3 of of IN cord-005453-4057qib7 9607 4 AdvT AdvT NNP cord-005453-4057qib7 9607 5 in in IN cord-005453-4057qib7 9607 6 potential potential JJ cord-005453-4057qib7 9607 7 HSCT HSCT NNP cord-005453-4057qib7 9607 8 donors donor NNS cord-005453-4057qib7 9607 9 will will MD cord-005453-4057qib7 9607 10 allow allow VB cord-005453-4057qib7 9607 11 to to TO cord-005453-4057qib7 9607 12 determine determine VB cord-005453-4057qib7 9607 13 more more RBR cord-005453-4057qib7 9607 14 accurately accurately RB cord-005453-4057qib7 9607 15 the the DT cord-005453-4057qib7 9607 16 amounts amount NNS cord-005453-4057qib7 9607 17 and and CC cord-005453-4057qib7 9607 18 functional functional JJ cord-005453-4057qib7 9607 19 activity activity NN cord-005453-4057qib7 9607 20 of of IN cord-005453-4057qib7 9607 21 specific specific JJ cord-005453-4057qib7 9607 22 antiviral antiviral JJ cord-005453-4057qib7 9607 23 T t NN cord-005453-4057qib7 9607 24 - - HYPH cord-005453-4057qib7 9607 25 lymphocytes lymphocyte NNS cord-005453-4057qib7 9607 26 administered administer VBN cord-005453-4057qib7 9607 27 to to TO cord-005453-4057qib7 9607 28 patient patient VB cord-005453-4057qib7 9607 29 and and CC cord-005453-4057qib7 9607 30 optimize optimize VB cord-005453-4057qib7 9607 31 antiviral antiviral JJ cord-005453-4057qib7 9607 32 therapy therapy NN cord-005453-4057qib7 9607 33 . . . cord-005453-4057qib7 9608 1 Disclosure disclosure NN cord-005453-4057qib7 9608 2 : : : cord-005453-4057qib7 9608 3 Nothing nothing NN cord-005453-4057qib7 9608 4 to to TO cord-005453-4057qib7 9608 5 declare declare VB cord-005453-4057qib7 9608 6 P429 P429 NNP cord-005453-4057qib7 9608 7 abstract abstract JJ cord-005453-4057qib7 9608 8 withdrawn withdraw VBN cord-005453-4057qib7 9608 9 . . . cord-005453-4057qib7 9609 1 Chemotaxis chemotaxis NN cord-005453-4057qib7 9609 2 and and CC cord-005453-4057qib7 9609 3 exhaustion exhaustion NN cord-005453-4057qib7 9609 4 of of IN cord-005453-4057qib7 9609 5 γδ γδ NN cord-005453-4057qib7 9609 6 T t NN cord-005453-4057qib7 9609 7 cells cell NNS cord-005453-4057qib7 9609 8 in in IN cord-005453-4057qib7 9609 9 the the DT cord-005453-4057qib7 9609 10 allografts allograft NNS cord-005453-4057qib7 9609 11 are be VBP cord-005453-4057qib7 9609 12 associated associate VBN cord-005453-4057qib7 9609 13 with with IN cord-005453-4057qib7 9609 14 CMV CMV NNP cord-005453-4057qib7 9609 15 reactivation reactivation NN cord-005453-4057qib7 9609 16 after after IN cord-005453-4057qib7 9609 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 9609 18 transplantation transplantation NN cord-005453-4057qib7 9609 19 Background background NN cord-005453-4057qib7 9609 20 : : : cord-005453-4057qib7 9610 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 9610 2 ( ( -LRB- cord-005453-4057qib7 9610 3 CMV CMV NNP cord-005453-4057qib7 9610 4 ) ) -RRB- cord-005453-4057qib7 9610 5 reactivation reactivation NN cord-005453-4057qib7 9610 6 and and CC cord-005453-4057qib7 9610 7 its -PRON- PRP$ cord-005453-4057qib7 9610 8 related related JJ cord-005453-4057qib7 9610 9 diseases disease NNS cord-005453-4057qib7 9610 10 remain remain VBP cord-005453-4057qib7 9610 11 the the DT cord-005453-4057qib7 9610 12 most most RBS cord-005453-4057qib7 9610 13 common common JJ cord-005453-4057qib7 9610 14 and and CC cord-005453-4057qib7 9610 15 serious serious JJ cord-005453-4057qib7 9610 16 complications complication NNS cord-005453-4057qib7 9610 17 in in IN cord-005453-4057qib7 9610 18 patients patient NNS cord-005453-4057qib7 9610 19 who who WP cord-005453-4057qib7 9610 20 underwentallogeneic underwentallogeneic VBZ cord-005453-4057qib7 9610 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 9610 22 stem stem NN cord-005453-4057qib7 9610 23 cell cell NN cord-005453-4057qib7 9610 24 transplantation transplantation NN cord-005453-4057qib7 9610 25 ( ( -LRB- cord-005453-4057qib7 9610 26 alloHSCT alloHSCT NNP cord-005453-4057qib7 9610 27 ) ) -RRB- cord-005453-4057qib7 9610 28 . . . cord-005453-4057qib7 9611 1 We -PRON- PRP cord-005453-4057qib7 9611 2 previously previously RB cord-005453-4057qib7 9611 3 reported report VBD cord-005453-4057qib7 9611 4 that that IN cord-005453-4057qib7 9611 5 the the DT cord-005453-4057qib7 9611 6 incidences incidence NNS cord-005453-4057qib7 9611 7 of of IN cord-005453-4057qib7 9611 8 total total JJ cord-005453-4057qib7 9611 9 and and CC cord-005453-4057qib7 9611 10 refractory refractory JJ cord-005453-4057qib7 9611 11 CMV CMV NNP cord-005453-4057qib7 9611 12 reactivation reactivation NN cord-005453-4057qib7 9611 13 reached reach VBD cord-005453-4057qib7 9611 14 approximately approximately RB cord-005453-4057qib7 9611 15 90 90 CD cord-005453-4057qib7 9611 16 % % NN cord-005453-4057qib7 9611 17 and and CC cord-005453-4057qib7 9611 18 50 50 CD cord-005453-4057qib7 9611 19 % % NN cord-005453-4057qib7 9611 20 after after IN cord-005453-4057qib7 9611 21 haploidentical haploidentical JJ cord-005453-4057qib7 9611 22 HSCT HSCT NNP cord-005453-4057qib7 9611 23 . . . cord-005453-4057qib7 9612 1 While while IN cord-005453-4057qib7 9612 2 majority majority NN cord-005453-4057qib7 9612 3 of of IN cord-005453-4057qib7 9612 4 studies study NNS cord-005453-4057qib7 9612 5 in in IN cord-005453-4057qib7 9612 6 the the DT cord-005453-4057qib7 9612 7 literatures literature NNS cord-005453-4057qib7 9612 8 focused focus VBN cord-005453-4057qib7 9612 9 on on IN cord-005453-4057qib7 9612 10 the the DT cord-005453-4057qib7 9612 11 adaptive adaptive JJ cord-005453-4057qib7 9612 12 CD8 CD8 NNP cord-005453-4057qib7 9612 13 + + CC cord-005453-4057qib7 9612 14 αβ αβ NNP cord-005453-4057qib7 9612 15 T T NNP cord-005453-4057qib7 9612 16 cellsand cellsand NN cord-005453-4057qib7 9612 17 NK NK NNP cord-005453-4057qib7 9612 18 cells cell NNS cord-005453-4057qib7 9612 19 in in IN cord-005453-4057qib7 9612 20 anti anti JJ cord-005453-4057qib7 9612 21 - - JJ cord-005453-4057qib7 9612 22 CMV CMV NNP cord-005453-4057qib7 9612 23 immunity immunity NN cord-005453-4057qib7 9612 24 , , , cord-005453-4057qib7 9612 25 increasing increase VBG cord-005453-4057qib7 9612 26 evidences evidence NNS cord-005453-4057qib7 9612 27 highlighted highlight VBD cord-005453-4057qib7 9612 28 the the DT cord-005453-4057qib7 9612 29 important important JJ cord-005453-4057qib7 9612 30 role role NN cord-005453-4057qib7 9612 31 of of IN cord-005453-4057qib7 9612 32 γδT γδt NN cord-005453-4057qib7 9612 33 cells cell NNS cord-005453-4057qib7 9612 34 in in IN cord-005453-4057qib7 9612 35 this this DT cord-005453-4057qib7 9612 36 context context NN cord-005453-4057qib7 9612 37 . . . cord-005453-4057qib7 9613 1 A a DT cord-005453-4057qib7 9613 2 progressive progressive JJ cord-005453-4057qib7 9613 3 and and CC cord-005453-4057qib7 9613 4 prolonged prolonged JJ cord-005453-4057qib7 9613 5 expansion expansion NN cord-005453-4057qib7 9613 6 of of IN cord-005453-4057qib7 9613 7 Vδ1 Vδ1 NNP cord-005453-4057qib7 9613 8 + + SYM cord-005453-4057qib7 9613 9 T t NN cord-005453-4057qib7 9613 10 cells cell NNS cord-005453-4057qib7 9613 11 in in IN cord-005453-4057qib7 9613 12 response response NN cord-005453-4057qib7 9613 13 to to IN cord-005453-4057qib7 9613 14 CMV CMV NNP cord-005453-4057qib7 9613 15 reactivation reactivation NN cord-005453-4057qib7 9613 16 was be VBD cord-005453-4057qib7 9613 17 observed observe VBN cord-005453-4057qib7 9613 18 after after IN cord-005453-4057qib7 9613 19 alloHSCT alloHSCT NNP cord-005453-4057qib7 9613 20 . . . cord-005453-4057qib7 9614 1 The the DT cord-005453-4057qib7 9614 2 effect effect NN cord-005453-4057qib7 9614 3 of of IN cord-005453-4057qib7 9614 4 Vδ1 vδ1 NN cord-005453-4057qib7 9614 5 + + SYM cord-005453-4057qib7 9614 6 T t NN cord-005453-4057qib7 9614 7 cells cell NNS cord-005453-4057qib7 9614 8 associated associate VBN cord-005453-4057qib7 9614 9 with with IN cord-005453-4057qib7 9614 10 CMV CMV NNP cord-005453-4057qib7 9614 11 clearance clearance NN cord-005453-4057qib7 9614 12 has have VBZ cord-005453-4057qib7 9614 13 been be VBN cord-005453-4057qib7 9614 14 reported report VBN cord-005453-4057qib7 9614 15 in in IN cord-005453-4057qib7 9614 16 vitro vitro FW cord-005453-4057qib7 9614 17 and and CC cord-005453-4057qib7 9614 18 in in IN cord-005453-4057qib7 9614 19 vivo vivo NNP cord-005453-4057qib7 9614 20 . . . cord-005453-4057qib7 9615 1 In in IN cord-005453-4057qib7 9615 2 contrast contrast NN cord-005453-4057qib7 9615 3 to to IN cord-005453-4057qib7 9615 4 the the DT cord-005453-4057qib7 9615 5 reconstituted reconstitute VBN cord-005453-4057qib7 9615 6 γδT γδT NNP cord-005453-4057qib7 9615 7 cells cell NNS cord-005453-4057qib7 9615 8 post post VBP cord-005453-4057qib7 9615 9 transplantation transplantation NN cord-005453-4057qib7 9615 10 , , , cord-005453-4057qib7 9615 11 whether whether IN cord-005453-4057qib7 9615 12 the the DT cord-005453-4057qib7 9615 13 phenotypes phenotype NNS cord-005453-4057qib7 9615 14 of of IN cord-005453-4057qib7 9615 15 γδT γδt NN cord-005453-4057qib7 9615 16 subsets subset NNS cord-005453-4057qib7 9615 17 in in IN cord-005453-4057qib7 9615 18 allografts allograft NNS cord-005453-4057qib7 9615 19 correlate correlate VBP cord-005453-4057qib7 9615 20 to to IN cord-005453-4057qib7 9615 21 CMV CMV NNP cord-005453-4057qib7 9615 22 reactivation reactivation NN cord-005453-4057qib7 9615 23 in in IN cord-005453-4057qib7 9615 24 HSCT HSCT NNP cord-005453-4057qib7 9615 25 recipients recipient NNS cord-005453-4057qib7 9615 26 have have VBP cord-005453-4057qib7 9615 27 not not RB cord-005453-4057qib7 9615 28 been be VBN cord-005453-4057qib7 9615 29 documented document VBN cord-005453-4057qib7 9615 30 . . . cord-005453-4057qib7 9616 1 Methods method NNS cord-005453-4057qib7 9616 2 : : : cord-005453-4057qib7 9616 3 The the DT cord-005453-4057qib7 9616 4 proportions proportion NNS cord-005453-4057qib7 9616 5 and and CC cord-005453-4057qib7 9616 6 phenotypes phenotype NNS cord-005453-4057qib7 9616 7 of of IN cord-005453-4057qib7 9616 8 γδ γδ NN cord-005453-4057qib7 9616 9 T t NN cord-005453-4057qib7 9616 10 cells cell NNS cord-005453-4057qib7 9616 11 were be VBD cord-005453-4057qib7 9616 12 detected detect VBN cord-005453-4057qib7 9616 13 inallografts inallografts NNP cord-005453-4057qib7 9617 1 those those DT cord-005453-4057qib7 9617 2 were be VBD cord-005453-4057qib7 9617 3 unmanipulated unmanipulated JJ cord-005453-4057qib7 9617 4 G G NNP cord-005453-4057qib7 9617 5 - - HYPH cord-005453-4057qib7 9617 6 CSF csf NN cord-005453-4057qib7 9617 7 - - HYPH cord-005453-4057qib7 9617 8 mobilized mobilize VBN cord-005453-4057qib7 9617 9 bone bone NN cord-005453-4057qib7 9617 10 marrow marrow NN cord-005453-4057qib7 9617 11 ( ( -LRB- cord-005453-4057qib7 9617 12 BM BM NNP cord-005453-4057qib7 9617 13 ) ) -RRB- cord-005453-4057qib7 9617 14 and and CC cord-005453-4057qib7 9617 15 peripheral peripheral JJ cord-005453-4057qib7 9617 16 blood blood NN cord-005453-4057qib7 9617 17 ( ( -LRB- cord-005453-4057qib7 9617 18 PB PB NNP cord-005453-4057qib7 9617 19 ) ) -RRB- cord-005453-4057qib7 9617 20 harvests harvest VBZ cord-005453-4057qib7 9617 21 from from IN cord-005453-4057qib7 9617 22 20 20 CD cord-005453-4057qib7 9617 23 donors donor NNS cord-005453-4057qib7 9617 24 for for IN cord-005453-4057qib7 9617 25 haploHSCT haploHSCT NNP cord-005453-4057qib7 9617 26 . . . cord-005453-4057qib7 9618 1 BM BM NNP cord-005453-4057qib7 9618 2 grafts graft NNS cord-005453-4057qib7 9618 3 were be VBD cord-005453-4057qib7 9618 4 collected collect VBN cord-005453-4057qib7 9618 5 by by IN cord-005453-4057qib7 9618 6 aspiration aspiration NN cord-005453-4057qib7 9618 7 on on IN cord-005453-4057qib7 9618 8 the the DT cord-005453-4057qib7 9618 9 fourth fourth JJ cord-005453-4057qib7 9618 10 day day NN cord-005453-4057qib7 9618 11 of of IN cord-005453-4057qib7 9618 12 G G NNP cord-005453-4057qib7 9618 13 - - HYPH cord-005453-4057qib7 9618 14 CSF csf NN cord-005453-4057qib7 9618 15 treatment treatment NN cord-005453-4057qib7 9618 16 ( ( -LRB- cord-005453-4057qib7 9618 17 filgrastim filgrastim NNP cord-005453-4057qib7 9618 18 , , , cord-005453-4057qib7 9618 19 5 5 CD cord-005453-4057qib7 9618 20 μg μg NNP cord-005453-4057qib7 9618 21 / / SYM cord-005453-4057qib7 9618 22 kg kg NNP cord-005453-4057qib7 9618 23 / / SYM cord-005453-4057qib7 9618 24 day day NN cord-005453-4057qib7 9618 25 ) ) -RRB- cord-005453-4057qib7 9618 26 , , , cord-005453-4057qib7 9618 27 and and CC cord-005453-4057qib7 9618 28 PB PB NNP cord-005453-4057qib7 9618 29 grafts graft NNS cord-005453-4057qib7 9618 30 were be VBD cord-005453-4057qib7 9618 31 obtained obtain VBN cord-005453-4057qib7 9618 32 on on IN cord-005453-4057qib7 9618 33 the the DT cord-005453-4057qib7 9618 34 fifth fifth JJ cord-005453-4057qib7 9618 35 day day NN cord-005453-4057qib7 9618 36 by by IN cord-005453-4057qib7 9618 37 leukapheresis leukapheresis NNP cord-005453-4057qib7 9618 38 . . . cord-005453-4057qib7 9619 1 Immunophenotyping immunophenotype VBG cord-005453-4057qib7 9619 2 for for IN cord-005453-4057qib7 9619 3 γδ γδ NNP cord-005453-4057qib7 9619 4 T t NN cord-005453-4057qib7 9619 5 - - HYPH cord-005453-4057qib7 9619 6 cell cell NN cord-005453-4057qib7 9619 7 subpopulations subpopulation NNS cord-005453-4057qib7 9619 8 , , , cord-005453-4057qib7 9619 9 including include VBG cord-005453-4057qib7 9619 10 the the DT cord-005453-4057qib7 9619 11 expression expression NN cord-005453-4057qib7 9619 12 of of IN cord-005453-4057qib7 9619 13 CD3 CD3 NNP cord-005453-4057qib7 9619 14 , , , cord-005453-4057qib7 9619 15 CD4 CD4 NNP cord-005453-4057qib7 9619 16 , , , cord-005453-4057qib7 9619 17 CD8 CD8 NNP cord-005453-4057qib7 9619 18 , , , cord-005453-4057qib7 9619 19 TCRγδ TCRγδ NNP cord-005453-4057qib7 9619 20 , , , cord-005453-4057qib7 9619 21 TCRVδ1 TCRVδ1 NNP cord-005453-4057qib7 9619 22 , , , cord-005453-4057qib7 9619 23 TCRVδ2 TCRVδ2 NNP cord-005453-4057qib7 9619 24 , , , cord-005453-4057qib7 9619 25 HLA HLA NNP cord-005453-4057qib7 9619 26 - - HYPH cord-005453-4057qib7 9619 27 DR DR NNP cord-005453-4057qib7 9619 28 , , , cord-005453-4057qib7 9619 29 NKG2D NKG2D NNP cord-005453-4057qib7 9619 30 , , , cord-005453-4057qib7 9619 31 CXCR4 CXCR4 NNP cord-005453-4057qib7 9619 32 , , , cord-005453-4057qib7 9619 33 CCR5 CCR5 NNP cord-005453-4057qib7 9619 34 , , , cord-005453-4057qib7 9619 35 PD1 PD1 NNP cord-005453-4057qib7 9619 36 , , , cord-005453-4057qib7 9619 37 ki67 ki67 NNP cord-005453-4057qib7 9619 38 , , , cord-005453-4057qib7 9619 39 IFNγ IFNγ NNS cord-005453-4057qib7 9619 40 , , , cord-005453-4057qib7 9619 41 TNFα TNFα NNS cord-005453-4057qib7 9619 42 , , , cord-005453-4057qib7 9619 43 and and CC cord-005453-4057qib7 9619 44 IL-17 IL-17 NNP cord-005453-4057qib7 9619 45 , , , cord-005453-4057qib7 9619 46 was be VBD cord-005453-4057qib7 9619 47 performed perform VBN cord-005453-4057qib7 9619 48 using use VBG cord-005453-4057qib7 9619 49 flow flow NN cord-005453-4057qib7 9619 50 cytometry cytometry NN cord-005453-4057qib7 9619 51 . . . cord-005453-4057qib7 9620 1 For for IN cord-005453-4057qib7 9620 2 detection detection NN cord-005453-4057qib7 9620 3 of of IN cord-005453-4057qib7 9620 4 the the DT cord-005453-4057qib7 9620 5 intracellular intracellular JJ cord-005453-4057qib7 9620 6 cytokines cytokine NNS cord-005453-4057qib7 9620 7 , , , cord-005453-4057qib7 9620 8 BM BM NNP cord-005453-4057qib7 9620 9 and and CC cord-005453-4057qib7 9620 10 PB PB NNP cord-005453-4057qib7 9620 11 grafts graft NNS cord-005453-4057qib7 9620 12 were be VBD cord-005453-4057qib7 9620 13 pre pre JJ cord-005453-4057qib7 9620 14 - - JJ cord-005453-4057qib7 9620 15 stimulated stimulate VBN cord-005453-4057qib7 9621 1 with with IN cord-005453-4057qib7 9621 2 1x 1x CD cord-005453-4057qib7 9621 3 Cell Cell NNP cord-005453-4057qib7 9621 4 Stimulation stimulation NN cord-005453-4057qib7 9621 5 Cocktail cocktail NN cord-005453-4057qib7 9621 6 ( ( -LRB- cord-005453-4057qib7 9621 7 500x 500x NNPS cord-005453-4057qib7 9621 8 , , , cord-005453-4057qib7 9621 9 eBioscience eBioscience NNP cord-005453-4057qib7 9621 10 ) ) -RRB- cord-005453-4057qib7 9621 11 . . . cord-005453-4057qib7 9622 1 CMV CMV NNP cord-005453-4057qib7 9622 2 DNA DNA NNP cord-005453-4057qib7 9622 3 in in IN cord-005453-4057qib7 9622 4 the the DT cord-005453-4057qib7 9622 5 peripheral peripheral JJ cord-005453-4057qib7 9622 6 blood blood NN cord-005453-4057qib7 9622 7 of of IN cord-005453-4057qib7 9622 8 recipients recipient NNS cord-005453-4057qib7 9622 9 was be VBD cord-005453-4057qib7 9622 10 routinely routinely RB cord-005453-4057qib7 9622 11 monitored monitor VBN cord-005453-4057qib7 9622 12 by by IN cord-005453-4057qib7 9622 13 quantitative quantitative JJ cord-005453-4057qib7 9622 14 PCR PCR NNP cord-005453-4057qib7 9622 15 . . . cord-005453-4057qib7 9623 1 The the DT cord-005453-4057qib7 9623 2 association association NN cord-005453-4057qib7 9623 3 of of IN cord-005453-4057qib7 9623 4 γδ γδ NNP cord-005453-4057qib7 9623 5 T T NNP cord-005453-4057qib7 9623 6 - - HYPH cord-005453-4057qib7 9623 7 cell cell NN cord-005453-4057qib7 9623 8 contents content NNS cord-005453-4057qib7 9623 9 in in IN cord-005453-4057qib7 9623 10 allografts allograft NNS cord-005453-4057qib7 9623 11 with with IN cord-005453-4057qib7 9623 12 CMV CMV NNP cord-005453-4057qib7 9623 13 reactivation reactivation NN cord-005453-4057qib7 9623 14 in in IN cord-005453-4057qib7 9623 15 haploHSCT haploHSCT NNP cord-005453-4057qib7 9623 16 recipients recipient NNS cord-005453-4057qib7 9623 17 was be VBD cord-005453-4057qib7 9623 18 analyzed analyze VBN cord-005453-4057qib7 9623 19 using use VBG cord-005453-4057qib7 9623 20 the the DT cord-005453-4057qib7 9623 21 Mann Mann NNP cord-005453-4057qib7 9623 22 - - HYPH cord-005453-4057qib7 9623 23 Whitney Whitney NNP cord-005453-4057qib7 9623 24 U U NNP cord-005453-4057qib7 9623 25 test test NN cord-005453-4057qib7 9623 26 and and CC cord-005453-4057qib7 9623 27 Spearman Spearman NNP cord-005453-4057qib7 9623 28 test test NN cord-005453-4057qib7 9623 29 . . . cord-005453-4057qib7 9624 1 All all DT cord-005453-4057qib7 9624 2 calculations calculation NNS cord-005453-4057qib7 9624 3 were be VBD cord-005453-4057qib7 9624 4 performed perform VBN cord-005453-4057qib7 9624 5 using use VBG cord-005453-4057qib7 9624 6 SPSS SPSS NNP cord-005453-4057qib7 9624 7 22.0 22.0 CD cord-005453-4057qib7 9624 8 statistical statistical JJ cord-005453-4057qib7 9624 9 software software NN cord-005453-4057qib7 9624 10 . . . cord-005453-4057qib7 9625 1 Results result NNS cord-005453-4057qib7 9625 2 : : : cord-005453-4057qib7 9626 1 We -PRON- PRP cord-005453-4057qib7 9626 2 found find VBD cord-005453-4057qib7 9626 3 that that IN cord-005453-4057qib7 9626 4 the the DT cord-005453-4057qib7 9626 5 proportions proportion NNS cord-005453-4057qib7 9626 6 of of IN cord-005453-4057qib7 9626 7 total total NN cord-005453-4057qib7 9626 8 γδ γδ NN cord-005453-4057qib7 9626 9 T t NN cord-005453-4057qib7 9626 10 cells cell NNS cord-005453-4057qib7 9626 11 , , , cord-005453-4057qib7 9626 12 and and CC cord-005453-4057qib7 9626 13 Vδ1 vδ1 NN cord-005453-4057qib7 9626 14 and and CC cord-005453-4057qib7 9626 15 Vδ2 vδ2 JJ cord-005453-4057qib7 9626 16 subsets subset NNS cord-005453-4057qib7 9626 17 in in IN cord-005453-4057qib7 9626 18 both both DT cord-005453-4057qib7 9626 19 BM BM NNP cord-005453-4057qib7 9626 20 and and CC cord-005453-4057qib7 9626 21 PB PB NNP cord-005453-4057qib7 9626 22 grafts graft NNS cord-005453-4057qib7 9626 23 for for IN cord-005453-4057qib7 9626 24 CMV+ CMV+ NNP cord-005453-4057qib7 9626 25 and and CC cord-005453-4057qib7 9626 26 CMV CMV NNP cord-005453-4057qib7 9626 27 - - HYPH cord-005453-4057qib7 9626 28 recipients recipient NNS cord-005453-4057qib7 9626 29 were be VBD cord-005453-4057qib7 9626 30 comparable comparable JJ cord-005453-4057qib7 9626 31 . . . cord-005453-4057qib7 9627 1 Neither neither CC cord-005453-4057qib7 9627 2 the the DT cord-005453-4057qib7 9627 3 expression expression NN cord-005453-4057qib7 9627 4 of of IN cord-005453-4057qib7 9627 5 HLA HLA NNP cord-005453-4057qib7 9627 6 - - HYPH cord-005453-4057qib7 9627 7 DR DR NNP cord-005453-4057qib7 9627 8 nor nor CC cord-005453-4057qib7 9627 9 NKG2D nkg2d NN cord-005453-4057qib7 9627 10 in in IN cord-005453-4057qib7 9627 11 the the DT cord-005453-4057qib7 9627 12 allografts allograft NNS cord-005453-4057qib7 9627 13 were be VBD cord-005453-4057qib7 9627 14 significantly significantly RB cord-005453-4057qib7 9627 15 different different JJ cord-005453-4057qib7 9627 16 in in IN cord-005453-4057qib7 9627 17 correlation correlation NN cord-005453-4057qib7 9627 18 to to IN cord-005453-4057qib7 9627 19 CMV CMV NNP cord-005453-4057qib7 9627 20 reactivation reactivation NN cord-005453-4057qib7 9627 21 after after IN cord-005453-4057qib7 9627 22 HSCT HSCT NNP cord-005453-4057qib7 9627 23 . . . cord-005453-4057qib7 9628 1 The the DT cord-005453-4057qib7 9628 2 productions production NNS cord-005453-4057qib7 9628 3 of of IN cord-005453-4057qib7 9628 4 intracellular intracellular JJ cord-005453-4057qib7 9628 5 cytokines cytokine NNS cord-005453-4057qib7 9628 6 of of IN cord-005453-4057qib7 9628 7 γδ γδ NN cord-005453-4057qib7 9628 8 T T NNP cord-005453-4057qib7 9628 9 subsets subset NNS cord-005453-4057qib7 9628 10 did do VBD cord-005453-4057qib7 9628 11 not not RB cord-005453-4057qib7 9628 12 varied varied JJ cord-005453-4057qib7 9628 13 in in IN cord-005453-4057qib7 9628 14 BM BM NNP cord-005453-4057qib7 9628 15 and and CC cord-005453-4057qib7 9628 16 PB PB NNP cord-005453-4057qib7 9628 17 grafts graft NNS cord-005453-4057qib7 9628 18 for for IN cord-005453-4057qib7 9628 19 CMV+ CMV+ NNP cord-005453-4057qib7 9628 20 and and CC cord-005453-4057qib7 9628 21 CMV CMV NNP cord-005453-4057qib7 9628 22 - - HYPH cord-005453-4057qib7 9628 23 recipients recipient NNS cord-005453-4057qib7 9628 24 . . . cord-005453-4057qib7 9629 1 Interestingly interestingly RB cord-005453-4057qib7 9629 2 , , , cord-005453-4057qib7 9629 3 the the DT cord-005453-4057qib7 9629 4 proportions proportion NNS cord-005453-4057qib7 9629 5 of of IN cord-005453-4057qib7 9629 6 CXCR4+Vδ1 CXCR4+Vδ1 NNP cord-005453-4057qib7 9629 7 and and CC cord-005453-4057qib7 9629 8 CCR5+Vδ1 ccr5+vδ1 JJ cord-005453-4057qib7 9629 9 cells cell NNS cord-005453-4057qib7 9629 10 in in IN cord-005453-4057qib7 9629 11 BM BM NNP cord-005453-4057qib7 9629 12 grafts graft NNS cord-005453-4057qib7 9629 13 for for IN cord-005453-4057qib7 9629 14 CMV CMV NNP cord-005453-4057qib7 9629 15 + + CC cord-005453-4057qib7 9629 16 recipients recipient NNS cord-005453-4057qib7 9629 17 were be VBD cord-005453-4057qib7 9629 18 significantly significantly RB cord-005453-4057qib7 9629 19 higher high JJR cord-005453-4057qib7 9629 20 than than IN cord-005453-4057qib7 9629 21 those those DT cord-005453-4057qib7 9629 22 for for IN cord-005453-4057qib7 9629 23 CMVrecipients cmvrecipient NNS cord-005453-4057qib7 9629 24 ( ( -LRB- cord-005453-4057qib7 9629 25 P p NN cord-005453-4057qib7 9629 26 = = SYM cord-005453-4057qib7 9629 27 0.012 0.012 CD cord-005453-4057qib7 9629 28 and and CC cord-005453-4057qib7 9629 29 0.045 0.045 CD cord-005453-4057qib7 9629 30 , , , cord-005453-4057qib7 9629 31 respectively respectively RB cord-005453-4057qib7 9629 32 ) ) -RRB- cord-005453-4057qib7 9629 33 . . . cord-005453-4057qib7 9630 1 Meanwhile meanwhile RB cord-005453-4057qib7 9630 2 , , , cord-005453-4057qib7 9630 3 PMA PMA NNP cord-005453-4057qib7 9630 4 - - HYPH cord-005453-4057qib7 9630 5 stimulated stimulate VBN cord-005453-4057qib7 9630 6 ki67+Vδ1 ki67+vδ1 JJ cord-005453-4057qib7 9630 7 cells cell NNS cord-005453-4057qib7 9630 8 in in IN cord-005453-4057qib7 9630 9 BM BM NNP cord-005453-4057qib7 9630 10 grafts graft NNS cord-005453-4057qib7 9630 11 for for IN cord-005453-4057qib7 9630 12 CMV+ CMV+ NNP cord-005453-4057qib7 9630 13 recipients recipient NNS cord-005453-4057qib7 9630 14 were be VBD cord-005453-4057qib7 9630 15 less less JJR cord-005453-4057qib7 9630 16 than than IN cord-005453-4057qib7 9630 17 those those DT cord-005453-4057qib7 9630 18 for for IN cord-005453-4057qib7 9630 19 CMV CMV NNP cord-005453-4057qib7 9630 20 - - HYPH cord-005453-4057qib7 9630 21 recipients recipient NNS cord-005453-4057qib7 9630 22 ( ( -LRB- cord-005453-4057qib7 9630 23 P p NN cord-005453-4057qib7 9630 24 = = SYM cord-005453-4057qib7 9630 25 0.039 0.039 CD cord-005453-4057qib7 9630 26 ) ) -RRB- cord-005453-4057qib7 9630 27 . . . cord-005453-4057qib7 9631 1 In in IN cord-005453-4057qib7 9631 2 parallel parallel NN cord-005453-4057qib7 9631 3 , , , cord-005453-4057qib7 9631 4 the the DT cord-005453-4057qib7 9631 5 concentration concentration NN cord-005453-4057qib7 9631 6 of of IN cord-005453-4057qib7 9631 7 PD1+Vδ1 pd1+vδ1 JJ cord-005453-4057qib7 9631 8 cells cell NNS cord-005453-4057qib7 9631 9 in in IN cord-005453-4057qib7 9631 10 PB PB NNP cord-005453-4057qib7 9631 11 grafts graft NNS cord-005453-4057qib7 9631 12 for for IN cord-005453-4057qib7 9631 13 CMV+ CMV+ NNP cord-005453-4057qib7 9631 14 recipients recipient NNS cord-005453-4057qib7 9631 15 were be VBD cord-005453-4057qib7 9631 16 significantly significantly RB cord-005453-4057qib7 9631 17 higher high JJR cord-005453-4057qib7 9631 18 than than IN cord-005453-4057qib7 9631 19 those those DT cord-005453-4057qib7 9631 20 for for IN cord-005453-4057qib7 9631 21 CMV CMV NNP cord-005453-4057qib7 9631 22 - - HYPH cord-005453-4057qib7 9631 23 recipients recipient NNS cord-005453-4057qib7 9631 24 ( ( -LRB- cord-005453-4057qib7 9631 25 P p NN cord-005453-4057qib7 9631 26 = = SYM cord-005453-4057qib7 9631 27 0.023 0.023 CD cord-005453-4057qib7 9631 28 ) ) -RRB- cord-005453-4057qib7 9631 29 . . . cord-005453-4057qib7 9632 1 Conclusions conclusion NNS cord-005453-4057qib7 9632 2 : : : cord-005453-4057qib7 9633 1 This this DT cord-005453-4057qib7 9633 2 study study NN cord-005453-4057qib7 9633 3 is be VBZ cord-005453-4057qib7 9633 4 the the DT cord-005453-4057qib7 9633 5 first first JJ cord-005453-4057qib7 9633 6 to to TO cord-005453-4057qib7 9633 7 connect connect VB cord-005453-4057qib7 9633 8 the the DT cord-005453-4057qib7 9633 9 chemotaxis chemotaxis NN cord-005453-4057qib7 9633 10 and and CC cord-005453-4057qib7 9633 11 exhaustion exhaustion NN cord-005453-4057qib7 9633 12 of of IN cord-005453-4057qib7 9633 13 γδ γδ NN cord-005453-4057qib7 9633 14 T t NN cord-005453-4057qib7 9633 15 cells cell NNS cord-005453-4057qib7 9633 16 in in IN cord-005453-4057qib7 9633 17 grafts graft NNS cord-005453-4057qib7 9633 18 to to IN cord-005453-4057qib7 9633 19 the the DT cord-005453-4057qib7 9633 20 risk risk NN cord-005453-4057qib7 9633 21 of of IN cord-005453-4057qib7 9633 22 CMV CMV NNP cord-005453-4057qib7 9633 23 infection infection NN cord-005453-4057qib7 9633 24 after after IN cord-005453-4057qib7 9633 25 allogeneic allogeneic NN cord-005453-4057qib7 9633 26 HSCT HSCT NNP cord-005453-4057qib7 9633 27 . . . cord-005453-4057qib7 9634 1 Future future JJ cord-005453-4057qib7 9634 2 studies study NNS cord-005453-4057qib7 9634 3 should should MD cord-005453-4057qib7 9634 4 explore explore VB cord-005453-4057qib7 9634 5 how how WRB cord-005453-4057qib7 9634 6 the the DT cord-005453-4057qib7 9634 7 expressions expression NNS cord-005453-4057qib7 9634 8 of of IN cord-005453-4057qib7 9634 9 chemokines chemokine NNS cord-005453-4057qib7 9634 10 and and CC cord-005453-4057qib7 9634 11 exhaustion exhaustion NN cord-005453-4057qib7 9634 12 marker marker NN cord-005453-4057qib7 9634 13 on on IN cord-005453-4057qib7 9634 14 the the DT cord-005453-4057qib7 9634 15 effector effector NN cord-005453-4057qib7 9634 16 γδ γδ IN cord-005453-4057qib7 9634 17 T T NNP cord-005453-4057qib7 9634 18 cells cell NNS cord-005453-4057qib7 9634 19 in in IN cord-005453-4057qib7 9634 20 allografts allograft NNS cord-005453-4057qib7 9634 21 facilitate facilitate VBP cord-005453-4057qib7 9634 22 CMV CMV NNP cord-005453-4057qib7 9634 23 replication replication NN cord-005453-4057qib7 9634 24 and/or and/or CC cord-005453-4057qib7 9634 25 dissemination dissemination NN cord-005453-4057qib7 9634 26 in in IN cord-005453-4057qib7 9634 27 the the DT cord-005453-4057qib7 9634 28 setting setting NN cord-005453-4057qib7 9634 29 of of IN cord-005453-4057qib7 9634 30 hematopoietic hematopoietic JJ cord-005453-4057qib7 9634 31 transplantation transplantation NN cord-005453-4057qib7 9634 32 . . . cord-005453-4057qib7 9635 1 Disclosure disclosure NN cord-005453-4057qib7 9635 2 : : : cord-005453-4057qib7 9636 1 All all DT cord-005453-4057qib7 9636 2 authors author NNS cord-005453-4057qib7 9636 3 do do VBP cord-005453-4057qib7 9636 4 not not RB cord-005453-4057qib7 9636 5 have have VB cord-005453-4057qib7 9636 6 conflicts conflict NNS cord-005453-4057qib7 9636 7 of of IN cord-005453-4057qib7 9636 8 interest interest NN cord-005453-4057qib7 9636 9 . . . cord-005453-4057qib7 9637 1 This this DT cord-005453-4057qib7 9637 2 study study NN cord-005453-4057qib7 9637 3 is be VBZ cord-005453-4057qib7 9637 4 supported support VBN cord-005453-4057qib7 9637 5 by by IN cord-005453-4057qib7 9637 6 the the DT cord-005453-4057qib7 9637 7 National National NNP cord-005453-4057qib7 9637 8 Natural Natural NNP cord-005453-4057qib7 9637 9 Science Science NNP cord-005453-4057qib7 9637 10 Foundation Foundation NNP cord-005453-4057qib7 9637 11 of of IN cord-005453-4057qib7 9637 12 China China NNP cord-005453-4057qib7 9637 13 ( ( -LRB- cord-005453-4057qib7 9637 14 Grants grant NNS cord-005453-4057qib7 9637 15 No.81770191 No.81770191 NNP cord-005453-4057qib7 9637 16 and and CC cord-005453-4057qib7 9637 17 No.81670167 No.81670167 NNP cord-005453-4057qib7 9637 18 ) ) -RRB- cord-005453-4057qib7 9638 1 Results result NNS cord-005453-4057qib7 9638 2 : : : cord-005453-4057qib7 9639 1 Incidence incidence NN cord-005453-4057qib7 9639 2 of of IN cord-005453-4057qib7 9639 3 IC IC NNP cord-005453-4057qib7 9639 4 was be VBD cord-005453-4057qib7 9639 5 2,9 2,9 CD cord-005453-4057qib7 9639 6 % % NN cord-005453-4057qib7 9639 7 : : : cord-005453-4057qib7 9639 8 allo allo NN cord-005453-4057qib7 9639 9 - - HYPH cord-005453-4057qib7 9639 10 HSCT HSCT NNP cord-005453-4057qib7 9639 11 -3 -3 NNP cord-005453-4057qib7 9639 12 % % NN cord-005453-4057qib7 9639 13 ( ( -LRB- cord-005453-4057qib7 9639 14 n=15 n=15 NNP cord-005453-4057qib7 9639 15 ) ) -RRB- cord-005453-4057qib7 9639 16 , , , cord-005453-4057qib7 9639 17 auto auto NN cord-005453-4057qib7 9639 18 - - HYPH cord-005453-4057qib7 9639 19 HSCT HSCT NNP cord-005453-4057qib7 9639 20 -2,7 -2,7 NN cord-005453-4057qib7 9639 21 % % NN cord-005453-4057qib7 9639 22 ( ( -LRB- cord-005453-4057qib7 9639 23 n=7 n=7 NN cord-005453-4057qib7 9639 24 ) ) -RRB- cord-005453-4057qib7 9639 25 . . . cord-005453-4057qib7 9640 1 The the DT cord-005453-4057qib7 9640 2 etiology etiology NN cord-005453-4057qib7 9640 3 : : : cord-005453-4057qib7 9640 4 C. C. NNP cord-005453-4057qib7 9640 5 parapsilosis parapsilosis NNP cord-005453-4057qib7 9640 6 50 50 CD cord-005453-4057qib7 9640 7 % % NN cord-005453-4057qib7 9640 8 , , , cord-005453-4057qib7 9640 9 C. C. NNP cord-005453-4057qib7 9640 10 albicans albican NNS cord-005453-4057qib7 9640 11 27 27 CD cord-005453-4057qib7 9640 12 % % NN cord-005453-4057qib7 9640 13 , , , cord-005453-4057qib7 9640 14 C. C. NNP cord-005453-4057qib7 9640 15 krusei krusei NNP cord-005453-4057qib7 9640 16 14 14 CD cord-005453-4057qib7 9640 17 % % NN cord-005453-4057qib7 9640 18 , , , cord-005453-4057qib7 9640 19 Candida Candida NNP cord-005453-4057qib7 9640 20 tropicalis tropicalis NNP cord-005453-4057qib7 9640 21 5 5 CD cord-005453-4057qib7 9640 22 % % NN cord-005453-4057qib7 9640 23 , , , cord-005453-4057qib7 9640 24 Candida Candida NNP cord-005453-4057qib7 9640 25 dubliniensis dubliniensis NN cord-005453-4057qib7 9640 26 4 4 CD cord-005453-4057qib7 9640 27 % % NN cord-005453-4057qib7 9640 28 . . . cord-005453-4057qib7 9641 1 The the DT cord-005453-4057qib7 9641 2 most most RBS cord-005453-4057qib7 9641 3 frequent frequent JJ cord-005453-4057qib7 9641 4 underlying underlie VBG cord-005453-4057qib7 9641 5 diseases disease NNS cord-005453-4057qib7 9641 6 was be VBD cord-005453-4057qib7 9641 7 acute acute JJ cord-005453-4057qib7 9641 8 leukemia leukemia NN cord-005453-4057qib7 9641 9 -45 -45 NNP cord-005453-4057qib7 9641 10 % % NN cord-005453-4057qib7 9641 11 ( ( -LRB- cord-005453-4057qib7 9641 12 n=10 n=10 NNP cord-005453-4057qib7 9641 13 ) ) -RRB- cord-005453-4057qib7 9641 14 . . . cord-005453-4057qib7 9642 1 The the DT cord-005453-4057qib7 9642 2 median median JJ cord-005453-4057qib7 9642 3 age age NN cord-005453-4057qib7 9642 4 was be VBD cord-005453-4057qib7 9642 5 8 8 CD cord-005453-4057qib7 9642 6 y.o y.o NNP cord-005453-4057qib7 9642 7 . . . cord-005453-4057qib7 9643 1 [ [ -LRB- cord-005453-4057qib7 9643 2 3 3 CD cord-005453-4057qib7 9643 3 month month NN cord-005453-4057qib7 9643 4 -18 -18 SYM cord-005453-4057qib7 9643 5 years year NNS cord-005453-4057qib7 9643 6 ] ] -RRB- cord-005453-4057qib7 9643 7 . . . cord-005453-4057qib7 9644 1 The the DT cord-005453-4057qib7 9644 2 median median JJ cord-005453-4057qib7 9644 3 day day NN cord-005453-4057qib7 9644 4 of of IN cord-005453-4057qib7 9644 5 onset onset NN cord-005453-4057qib7 9644 6 of of IN cord-005453-4057qib7 9644 7 IC IC NNP cord-005453-4057qib7 9644 8 after after IN cord-005453-4057qib7 9644 9 allo allo NN cord-005453-4057qib7 9644 10 - - HYPH cord-005453-4057qib7 9644 11 HSCT HSCT NNP cord-005453-4057qib7 9644 12 was be VBD cord-005453-4057qib7 9644 13 63 63 CD cord-005453-4057qib7 9644 14 , , , cord-005453-4057qib7 9644 15 auto auto NN cord-005453-4057qib7 9644 16 - - HYPH cord-005453-4057qib7 9644 17 HSCT HSCT NNP cord-005453-4057qib7 9644 18 -12 -12 : cord-005453-4057qib7 9644 19 [ [ -LRB- cord-005453-4057qib7 9644 20 3 3 CD cord-005453-4057qib7 9644 21 ] ] -RRB- cord-005453-4057qib7 9644 22 [ [ -LRB- cord-005453-4057qib7 9644 23 4 4 CD cord-005453-4057qib7 9644 24 ] ] -RRB- cord-005453-4057qib7 9644 25 [ [ -LRB- cord-005453-4057qib7 9644 26 5 5 CD cord-005453-4057qib7 9644 27 ] ] -RRB- cord-005453-4057qib7 9644 28 [ [ -LRB- cord-005453-4057qib7 9644 29 6 6 CD cord-005453-4057qib7 9644 30 ] ] -RRB- cord-005453-4057qib7 9644 31 [ [ -LRB- cord-005453-4057qib7 9644 32 7 7 CD cord-005453-4057qib7 9644 33 ] ] -RRB- cord-005453-4057qib7 9645 1 [ [ -LRB- cord-005453-4057qib7 9645 2 8 8 CD cord-005453-4057qib7 9645 3 ] ] -RRB- cord-005453-4057qib7 9645 4 [ [ -LRB- cord-005453-4057qib7 9645 5 9 9 CD cord-005453-4057qib7 9645 6 ] ] -RRB- cord-005453-4057qib7 9645 7 [ [ -LRB- cord-005453-4057qib7 9645 8 10 10 CD cord-005453-4057qib7 9645 9 ] ] -RRB- cord-005453-4057qib7 9645 10 [ [ -LRB- cord-005453-4057qib7 9645 11 11 11 CD cord-005453-4057qib7 9645 12 ] ] -RRB- cord-005453-4057qib7 9646 1 [ [ -LRB- cord-005453-4057qib7 9646 2 12 12 CD cord-005453-4057qib7 9646 3 ] ] -RRB- cord-005453-4057qib7 9646 4 [ [ -LRB- cord-005453-4057qib7 9646 5 13 13 CD cord-005453-4057qib7 9646 6 ] ] -RRB- cord-005453-4057qib7 9647 1 [ [ -LRB- cord-005453-4057qib7 9647 2 14 14 CD cord-005453-4057qib7 9647 3 ] ] -RRB- cord-005453-4057qib7 9648 1 [ [ -LRB- cord-005453-4057qib7 9648 2 15 15 CD cord-005453-4057qib7 9648 3 ] ] -RRB- cord-005453-4057qib7 9648 4 [ [ -LRB- cord-005453-4057qib7 9648 5 16 16 CD cord-005453-4057qib7 9648 6 ] ] -RRB- cord-005453-4057qib7 9648 7 [ [ -LRB- cord-005453-4057qib7 9648 8 17 17 CD cord-005453-4057qib7 9648 9 ] ] -RRB- cord-005453-4057qib7 9648 10 [ [ -LRB- cord-005453-4057qib7 9648 11 18 18 CD cord-005453-4057qib7 9648 12 ] ] -RRB- cord-005453-4057qib7 9648 13 [ [ -LRB- cord-005453-4057qib7 9648 14 19 19 CD cord-005453-4057qib7 9648 15 ] ] -RRB- cord-005453-4057qib7 9648 16 [ [ -LRB- cord-005453-4057qib7 9648 17 20 20 CD cord-005453-4057qib7 9648 18 ] ] -RRB- cord-005453-4057qib7 9648 19 . . . cord-005453-4057qib7 9649 1 Febrile febrile JJ cord-005453-4057qib7 9649 2 fever fever NN cord-005453-4057qib7 9649 3 was be VBD cord-005453-4057qib7 9649 4 the the DT cord-005453-4057qib7 9649 5 main main JJ cord-005453-4057qib7 9649 6 clinical clinical JJ cord-005453-4057qib7 9649 7 symptom symptom NN cord-005453-4057qib7 9649 8 ; ; : cord-005453-4057qib7 9649 9 septic septic JJ cord-005453-4057qib7 9649 10 syndrome syndrome NN cord-005453-4057qib7 9649 11 develops develop VBZ cord-005453-4057qib7 9649 12 in in IN cord-005453-4057qib7 9649 13 32 32 CD cord-005453-4057qib7 9649 14 % % NN cord-005453-4057qib7 9649 15 cases case NNS cord-005453-4057qib7 9649 16 . . . cord-005453-4057qib7 9650 1 Antifungal antifungal JJ cord-005453-4057qib7 9650 2 therapy therapy NN cord-005453-4057qib7 9650 3 was be VBD cord-005453-4057qib7 9650 4 with with IN cord-005453-4057qib7 9650 5 echinocandins echinocandin NNS cord-005453-4057qib7 9650 6 -23 -23 CD cord-005453-4057qib7 9650 7 % % NN cord-005453-4057qib7 9650 8 , , , cord-005453-4057qib7 9650 9 lipid lipid NN cord-005453-4057qib7 9650 10 ampho ampho NN cord-005453-4057qib7 9650 11 B b NN cord-005453-4057qib7 9651 1 -27 -27 CD cord-005453-4057qib7 9651 2 % % NN cord-005453-4057qib7 9651 3 , , , cord-005453-4057qib7 9651 4 azoles azoles NNP cord-005453-4057qib7 9651 5 ( ( -LRB- cord-005453-4057qib7 9651 6 fluconazole fluconazole NNP cord-005453-4057qib7 9651 7 , , , cord-005453-4057qib7 9651 8 voriconazole voriconazole NN cord-005453-4057qib7 9651 9 ) ) -RRB- cord-005453-4057qib7 9652 1 -32 -32 NN cord-005453-4057qib7 9652 2 % % NN cord-005453-4057qib7 9652 3 , , , cord-005453-4057qib7 9652 4 without without IN cord-005453-4057qib7 9652 5 therapy therapy NN cord-005453-4057qib7 9652 6 ( ( -LRB- cord-005453-4057qib7 9652 7 the the DT cord-005453-4057qib7 9652 8 early early JJ cord-005453-4057qib7 9652 9 mortality mortality NN cord-005453-4057qib7 9652 10 ) ) -RRB- cord-005453-4057qib7 9652 11 -18 -18 CD cord-005453-4057qib7 9652 12 % % NN cord-005453-4057qib7 9652 13 . . . cord-005453-4057qib7 9653 1 Overall overall JJ cord-005453-4057qib7 9653 2 survival survival NN cord-005453-4057qib7 9653 3 ( ( -LRB- cord-005453-4057qib7 9653 4 OS OS NNP cord-005453-4057qib7 9653 5 ) ) -RRB- cord-005453-4057qib7 9653 6 at at IN cord-005453-4057qib7 9653 7 30 30 CD cord-005453-4057qib7 9653 8 days day NNS cord-005453-4057qib7 9653 9 from from IN cord-005453-4057qib7 9653 10 diagnosis diagnosis NN cord-005453-4057qib7 9653 11 of of IN cord-005453-4057qib7 9653 12 invasive invasive JJ cord-005453-4057qib7 9653 13 candidiasis candidiasis NN cord-005453-4057qib7 9653 14 was be VBD cord-005453-4057qib7 9653 15 50 50 CD cord-005453-4057qib7 9653 16 % % NN cord-005453-4057qib7 9653 17 . . . cord-005453-4057qib7 9654 1 The the DT cord-005453-4057qib7 9654 2 central central JJ cord-005453-4057qib7 9654 3 venous venous JJ cord-005453-4057qib7 9654 4 catheter catheter NN cord-005453-4057qib7 9654 5 ( ( -LRB- cord-005453-4057qib7 9654 6 CVC CVC NNP cord-005453-4057qib7 9654 7 ) ) -RRB- cord-005453-4057qib7 9654 8 removal removal NN cord-005453-4057qib7 9654 9 was be VBD cord-005453-4057qib7 9654 10 the the DT cord-005453-4057qib7 9654 11 only only JJ cord-005453-4057qib7 9654 12 factor factor NN cord-005453-4057qib7 9654 13 significantly significantly RB cord-005453-4057qib7 9654 14 improved improve VBD cord-005453-4057qib7 9654 15 OS OS NNP cord-005453-4057qib7 9654 16 ( ( -LRB- cord-005453-4057qib7 9654 17 70 70 CD cord-005453-4057qib7 9654 18 % % NN cord-005453-4057qib7 9654 19 vs vs IN cord-005453-4057qib7 9654 20 33 33 CD cord-005453-4057qib7 9654 21 % % NN cord-005453-4057qib7 9654 22 , , , cord-005453-4057qib7 9654 23 p=0,035 p=0,035 NNP cord-005453-4057qib7 9654 24 ) ) -RRB- cord-005453-4057qib7 9654 25 . . . cord-005453-4057qib7 9655 1 Conclusions conclusion NNS cord-005453-4057qib7 9655 2 : : : cord-005453-4057qib7 9656 1 Incidence incidence NN cord-005453-4057qib7 9656 2 of of IN cord-005453-4057qib7 9656 3 invasive invasive JJ cord-005453-4057qib7 9656 4 candidiasis candidiasi NNS cord-005453-4057qib7 9656 5 in in IN cord-005453-4057qib7 9656 6 children child NNS cord-005453-4057qib7 9656 7 after after IN cord-005453-4057qib7 9656 8 hematopoietic hematopoietic JJ cord-005453-4057qib7 9656 9 stem stem NN cord-005453-4057qib7 9656 10 cell cell NN cord-005453-4057qib7 9656 11 transplantation transplantation NN cord-005453-4057qib7 9656 12 was be VBD cord-005453-4057qib7 9656 13 2.9 2.9 CD cord-005453-4057qib7 9656 14 % % NN cord-005453-4057qib7 9656 15 . . . cord-005453-4057qib7 9657 1 The the DT cord-005453-4057qib7 9657 2 main main JJ cord-005453-4057qib7 9657 3 etiology etiology NN cord-005453-4057qib7 9657 4 agent agent NN cord-005453-4057qib7 9657 5 was be VBD cord-005453-4057qib7 9657 6 C. C. NNP cord-005453-4057qib7 9657 7 parapsilosis parapsilosis NNP cord-005453-4057qib7 9657 8 . . . cord-005453-4057qib7 9658 1 Invasive invasive JJ cord-005453-4057qib7 9658 2 candidiasis candidiasis NN cord-005453-4057qib7 9658 3 infections infection NNS cord-005453-4057qib7 9658 4 most most RBS cord-005453-4057qib7 9658 5 often often RB cord-005453-4057qib7 9658 6 affect affect VBP cord-005453-4057qib7 9658 7 leukemia leukemia NN cord-005453-4057qib7 9658 8 patients patient NNS cord-005453-4057qib7 9658 9 , , , cord-005453-4057qib7 9658 10 developed develop VBN cord-005453-4057qib7 9658 11 later later RB cord-005453-4057qib7 9658 12 after after IN cord-005453-4057qib7 9658 13 allo allo NN cord-005453-4057qib7 9658 14 - - HYPH cord-005453-4057qib7 9658 15 HSCT HSCT NNP cord-005453-4057qib7 9658 16 than than IN cord-005453-4057qib7 9658 17 auto auto NN cord-005453-4057qib7 9658 18 - - HYPH cord-005453-4057qib7 9658 19 HSCT HSCT NNP cord-005453-4057qib7 9658 20 . . . cord-005453-4057qib7 9659 1 Overall overall JJ cord-005453-4057qib7 9659 2 survival survival NN cord-005453-4057qib7 9659 3 at at IN cord-005453-4057qib7 9659 4 30 30 CD cord-005453-4057qib7 9659 5 days day NNS cord-005453-4057qib7 9659 6 from from IN cord-005453-4057qib7 9659 7 the the DT cord-005453-4057qib7 9659 8 diagnosis diagnosis NN cord-005453-4057qib7 9659 9 was be VBD cord-005453-4057qib7 9659 10 50 50 CD cord-005453-4057qib7 9659 11 % % NN cord-005453-4057qib7 9659 12 . . . cord-005453-4057qib7 9660 1 Removing remove VBG cord-005453-4057qib7 9660 2 of of IN cord-005453-4057qib7 9660 3 CVC CVC NNP cord-005453-4057qib7 9660 4 improved improve VBD cord-005453-4057qib7 9660 5 overall overall JJ cord-005453-4057qib7 9660 6 survival survival NN cord-005453-4057qib7 9660 7 in in IN cord-005453-4057qib7 9660 8 children child NNS cord-005453-4057qib7 9660 9 with with IN cord-005453-4057qib7 9660 10 invasive invasive JJ cord-005453-4057qib7 9660 11 candida candida NN cord-005453-4057qib7 9660 12 infections infection NNS cord-005453-4057qib7 9660 13 after after IN cord-005453-4057qib7 9660 14 HSCT HSCT NNP cord-005453-4057qib7 9660 15 . . . cord-005453-4057qib7 9661 1 Disclosure disclosure NN cord-005453-4057qib7 9661 2 : : : cord-005453-4057qib7 9661 3 Nothing nothing NN cord-005453-4057qib7 9661 4 to to TO cord-005453-4057qib7 9661 5 declare declare VB cord-005453-4057qib7 9661 6 Background background NN cord-005453-4057qib7 9661 7 : : : cord-005453-4057qib7 9661 8 Graft graft NN cord-005453-4057qib7 9661 9 versus versus IN cord-005453-4057qib7 9661 10 host host NN cord-005453-4057qib7 9661 11 disease disease NN cord-005453-4057qib7 9661 12 ( ( -LRB- cord-005453-4057qib7 9661 13 GvHD GvHD NNP cord-005453-4057qib7 9661 14 ) ) -RRB- cord-005453-4057qib7 9661 15 and and CC cord-005453-4057qib7 9661 16 virusassociated virusassociate VBD cord-005453-4057qib7 9661 17 enteropathy enteropathy NNP cord-005453-4057qib7 9661 18 in in IN cord-005453-4057qib7 9661 19 allogeneic allogeneic JJ cord-005453-4057qib7 9661 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 9661 21 stem stem NN cord-005453-4057qib7 9661 22 cell cell NN cord-005453-4057qib7 9661 23 transplantation transplantation NN cord-005453-4057qib7 9661 24 ( ( -LRB- cord-005453-4057qib7 9661 25 allo allo NN cord-005453-4057qib7 9661 26 - - HYPH cord-005453-4057qib7 9661 27 HSCT HSCT NNP cord-005453-4057qib7 9661 28 ) ) -RRB- cord-005453-4057qib7 9661 29 may may MD cord-005453-4057qib7 9661 30 cause cause VB cord-005453-4057qib7 9661 31 severe severe JJ cord-005453-4057qib7 9661 32 quantitative quantitative JJ cord-005453-4057qib7 9661 33 and and CC cord-005453-4057qib7 9661 34 qualitative qualitative JJ cord-005453-4057qib7 9661 35 composition composition NN cord-005453-4057qib7 9661 36 changes change NNS cord-005453-4057qib7 9661 37 of of IN cord-005453-4057qib7 9661 38 intestinal intestinal JJ cord-005453-4057qib7 9661 39 microbiota microbiota NN cord-005453-4057qib7 9661 40 , , , cord-005453-4057qib7 9661 41 leading lead VBG cord-005453-4057qib7 9661 42 to to IN cord-005453-4057qib7 9661 43 the the DT cord-005453-4057qib7 9661 44 development development NN cord-005453-4057qib7 9661 45 of of IN cord-005453-4057qib7 9661 46 small small JJ cord-005453-4057qib7 9661 47 intestinal intestinal JJ cord-005453-4057qib7 9661 48 bacterial bacterial JJ cord-005453-4057qib7 9661 49 overgrowth overgrowth NN cord-005453-4057qib7 9661 50 ( ( -LRB- cord-005453-4057qib7 9661 51 SIBO SIBO NNP cord-005453-4057qib7 9661 52 ) ) -RRB- cord-005453-4057qib7 9661 53 on on IN cord-005453-4057qib7 9661 54 the the DT cord-005453-4057qib7 9661 55 background background NN cord-005453-4057qib7 9661 56 of of IN cord-005453-4057qib7 9661 57 immunodeficiency immunodeficiency NN cord-005453-4057qib7 9661 58 , , , cord-005453-4057qib7 9661 59 which which WDT cord-005453-4057qib7 9661 60 can can MD cord-005453-4057qib7 9661 61 have have VB cord-005453-4057qib7 9661 62 a a DT cord-005453-4057qib7 9661 63 negative negative JJ cord-005453-4057qib7 9661 64 impact impact NN cord-005453-4057qib7 9661 65 on on IN cord-005453-4057qib7 9661 66 treatment treatment NN cord-005453-4057qib7 9661 67 effectiveness effectiveness NN cord-005453-4057qib7 9661 68 . . . cord-005453-4057qib7 9662 1 The the DT cord-005453-4057qib7 9662 2 gold gold NN cord-005453-4057qib7 9662 3 standard standard NN cord-005453-4057qib7 9662 4 for for IN cord-005453-4057qib7 9662 5 diagnosis diagnosis NN cord-005453-4057qib7 9662 6 and and CC cord-005453-4057qib7 9662 7 the the DT cord-005453-4057qib7 9662 8 main main JJ cord-005453-4057qib7 9662 9 criterion criterion NN cord-005453-4057qib7 9662 10 for for IN cord-005453-4057qib7 9662 11 SIBO SIBO NNP cord-005453-4057qib7 9662 12 is be VBZ cord-005453-4057qib7 9662 13 the the DT cord-005453-4057qib7 9662 14 detection detection NN cord-005453-4057qib7 9662 15 in in IN cord-005453-4057qib7 9662 16 the the DT cord-005453-4057qib7 9662 17 jejunum jejunum NN cord-005453-4057qib7 9662 18 aspirate aspirate VB cord-005453-4057qib7 9662 19 > > XX cord-005453-4057qib7 9662 20 10 10 CD cord-005453-4057qib7 9662 21 5 5 CD cord-005453-4057qib7 9663 1 /ml /ml . cord-005453-4057qib7 9664 1 bacteria bacteria NNS cord-005453-4057qib7 9664 2 and/or and/or CC cord-005453-4057qib7 9664 3 the the DT cord-005453-4057qib7 9664 4 appearance appearance NN cord-005453-4057qib7 9664 5 of of IN cord-005453-4057qib7 9664 6 colonlike colonlike NNP cord-005453-4057qib7 9664 7 microbiota microbiota NN cord-005453-4057qib7 9664 8 in in IN cord-005453-4057qib7 9664 9 small small JJ cord-005453-4057qib7 9664 10 intestine intestine NN cord-005453-4057qib7 9664 11 . . . cord-005453-4057qib7 9665 1 It -PRON- PRP cord-005453-4057qib7 9665 2 is be VBZ cord-005453-4057qib7 9665 3 also also RB cord-005453-4057qib7 9665 4 acceptable acceptable JJ cord-005453-4057qib7 9665 5 to to TO cord-005453-4057qib7 9665 6 use use VB cord-005453-4057qib7 9665 7 an an DT cord-005453-4057qib7 9665 8 alternative alternative JJ cord-005453-4057qib7 9665 9 non non JJ cord-005453-4057qib7 9665 10 - - JJ cord-005453-4057qib7 9665 11 invasive invasive JJ cord-005453-4057qib7 9665 12 technique technique NN cord-005453-4057qib7 9665 13 -hydrogen -hydrogen NN cord-005453-4057qib7 9665 14 breath breath NN cord-005453-4057qib7 9665 15 test test NN cord-005453-4057qib7 9665 16 , , , cord-005453-4057qib7 9665 17 which which WDT cord-005453-4057qib7 9665 18 could could MD cord-005453-4057qib7 9665 19 be be VB cord-005453-4057qib7 9665 20 especially especially RB cord-005453-4057qib7 9665 21 important important JJ cord-005453-4057qib7 9665 22 in in IN cord-005453-4057qib7 9665 23 patients patient NNS cord-005453-4057qib7 9665 24 with with IN cord-005453-4057qib7 9665 25 severe severe JJ cord-005453-4057qib7 9665 26 mucositis mucositis NN cord-005453-4057qib7 9665 27 , , , cord-005453-4057qib7 9665 28 grade grade NN cord-005453-4057qib7 9665 29 III III NNP cord-005453-4057qib7 9665 30 - - HYPH cord-005453-4057qib7 9665 31 IV IV NNP cord-005453-4057qib7 9665 32 and and CC cord-005453-4057qib7 9665 33 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 9665 34 grade grade NN cord-005453-4057qib7 9665 35 IV IV NNP cord-005453-4057qib7 9665 36 . . . cord-005453-4057qib7 9666 1 SIBO SIBO NNP cord-005453-4057qib7 9666 2 diagnosis diagnosis NN cord-005453-4057qib7 9666 3 in in IN cord-005453-4057qib7 9666 4 the the DT cord-005453-4057qib7 9666 5 setting setting NN cord-005453-4057qib7 9666 6 of of IN cord-005453-4057qib7 9666 7 the the DT cord-005453-4057qib7 9666 8 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 9666 9 tract tract NN cord-005453-4057qib7 9666 10 damage damage NN cord-005453-4057qib7 9666 11 and and CC cord-005453-4057qib7 9666 12 dysfunction dysfunction NN cord-005453-4057qib7 9666 13 in in IN cord-005453-4057qib7 9666 14 patients patient NNS cord-005453-4057qib7 9666 15 treated treat VBN cord-005453-4057qib7 9666 16 with with IN cord-005453-4057qib7 9666 17 allo allo NN cord-005453-4057qib7 9666 18 - - HYPH cord-005453-4057qib7 9666 19 HSCT HSCT NNP cord-005453-4057qib7 9666 20 is be VBZ cord-005453-4057qib7 9666 21 insufficiently insufficiently RB cord-005453-4057qib7 9666 22 studied study VBN cord-005453-4057qib7 9666 23 . . . cord-005453-4057qib7 9667 1 Methods method NNS cord-005453-4057qib7 9667 2 : : : cord-005453-4057qib7 9668 1 The the DT cord-005453-4057qib7 9668 2 study study NN cord-005453-4057qib7 9668 3 included include VBD cord-005453-4057qib7 9668 4 7 7 CD cord-005453-4057qib7 9668 5 patients patient NNS cord-005453-4057qib7 9668 6 with with IN cord-005453-4057qib7 9668 7 acute acute JJ cord-005453-4057qib7 9668 8 myeloid myeloid NN cord-005453-4057qib7 9668 9 leukemia leukemia NN cord-005453-4057qib7 9668 10 ( ( -LRB- cord-005453-4057qib7 9668 11 n=3 n=3 NN cord-005453-4057qib7 9668 12 ) ) -RRB- cord-005453-4057qib7 9668 13 , , , cord-005453-4057qib7 9668 14 acute acute JJ cord-005453-4057qib7 9668 15 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 9668 16 leukemia leukemia NN cord-005453-4057qib7 9668 17 ( ( -LRB- cord-005453-4057qib7 9668 18 n=1 n=1 CD cord-005453-4057qib7 9668 19 ) ) -RRB- cord-005453-4057qib7 9668 20 , , , cord-005453-4057qib7 9668 21 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 9668 22 syndrome syndrome NN cord-005453-4057qib7 9668 23 ( ( -LRB- cord-005453-4057qib7 9668 24 n=1 n=1 CD cord-005453-4057qib7 9668 25 ) ) -RRB- cord-005453-4057qib7 9668 26 , , , cord-005453-4057qib7 9668 27 non non JJ cord-005453-4057qib7 9668 28 - - JJ cord-005453-4057qib7 9668 29 Hodgkin´s hodgkin´s JJ cord-005453-4057qib7 9668 30 lymphoma lymphoma NN cord-005453-4057qib7 9668 31 ( ( -LRB- cord-005453-4057qib7 9668 32 n=1 n=1 CD cord-005453-4057qib7 9668 33 ) ) -RRB- cord-005453-4057qib7 9668 34 , , , cord-005453-4057qib7 9668 35 Hurler Hurler NNP cord-005453-4057qib7 9668 36 syndrome syndrome NN cord-005453-4057qib7 9668 37 ( ( -LRB- cord-005453-4057qib7 9668 38 n=1 n=1 CD cord-005453-4057qib7 9668 39 ) ) -RRB- cord-005453-4057qib7 9668 40 , , , cord-005453-4057qib7 9668 41 who who WP cord-005453-4057qib7 9668 42 underwent undergo VBD cord-005453-4057qib7 9668 43 allo allo NN cord-005453-4057qib7 9668 44 - - HYPH cord-005453-4057qib7 9668 45 HSCT HSCT NNP cord-005453-4057qib7 9668 46 from from IN cord-005453-4057qib7 9668 47 an an DT cord-005453-4057qib7 9668 48 unrelated unrelated JJ cord-005453-4057qib7 9668 49 ( ( -LRB- cord-005453-4057qib7 9668 50 n=4 n=4 JJ cord-005453-4057qib7 9668 51 ) ) -RRB- cord-005453-4057qib7 9668 52 and and CC cord-005453-4057qib7 9668 53 haploidentical haploidentical JJ cord-005453-4057qib7 9668 54 donor donor NN cord-005453-4057qib7 9668 55 ( ( -LRB- cord-005453-4057qib7 9668 56 n=3 n=3 NN cord-005453-4057qib7 9668 57 ) ) -RRB- cord-005453-4057qib7 9668 58 , , , cord-005453-4057qib7 9668 59 and and CC cord-005453-4057qib7 9668 60 which which WDT cord-005453-4057qib7 9668 61 were be VBD cord-005453-4057qib7 9668 62 complicated complicate VBN cord-005453-4057qib7 9668 63 by by IN cord-005453-4057qib7 9668 64 enteropathy enteropathy NNP cord-005453-4057qib7 9668 65 development development NN cord-005453-4057qib7 9668 66 . . . cord-005453-4057qib7 9669 1 In in IN cord-005453-4057qib7 9669 2 2 2 CD cord-005453-4057qib7 9669 3 cases case NNS cord-005453-4057qib7 9669 4 , , , cord-005453-4057qib7 9669 5 the the DT cord-005453-4057qib7 9669 6 enteropathy enteropathy NNP cord-005453-4057qib7 9669 7 reason reason NN cord-005453-4057qib7 9669 8 was be VBD cord-005453-4057qib7 9669 9 a a DT cord-005453-4057qib7 9669 10 combination combination NN cord-005453-4057qib7 9669 11 of of IN cord-005453-4057qib7 9669 12 intestinal intestinal JJ cord-005453-4057qib7 9669 13 GvHD gvhd NN cord-005453-4057qib7 9669 14 and and CC cord-005453-4057qib7 9669 15 viral viral JJ cord-005453-4057qib7 9669 16 colitis colitis NN cord-005453-4057qib7 9669 17 ( ( -LRB- cord-005453-4057qib7 9669 18 HHV-6 HHV-6 NNP cord-005453-4057qib7 9669 19 ) ) -RRB- cord-005453-4057qib7 9669 20 , , , cord-005453-4057qib7 9669 21 in in IN cord-005453-4057qib7 9669 22 5 5 CD cord-005453-4057qib7 9669 23 cases case NNS cord-005453-4057qib7 9669 24 -viral -viral JJ cord-005453-4057qib7 9669 25 colitis colitis NN cord-005453-4057qib7 9669 26 ( ( -LRB- cord-005453-4057qib7 9669 27 HHV-6 HHV-6 NNP cord-005453-4057qib7 9669 28 ) ) -RRB- cord-005453-4057qib7 9669 29 . . . cord-005453-4057qib7 9670 1 All all DT cord-005453-4057qib7 9670 2 patients patient NNS cord-005453-4057qib7 9670 3 had have VBD cord-005453-4057qib7 9670 4 esophagogastroduodenoscopy esophagogastroduodenoscopy NNS cord-005453-4057qib7 9670 5 with with IN cord-005453-4057qib7 9670 6 species specie NNS cord-005453-4057qib7 9670 7 aspiration aspiration NN cord-005453-4057qib7 9670 8 from from IN cord-005453-4057qib7 9670 9 descending descend VBG cord-005453-4057qib7 9670 10 part part NN cord-005453-4057qib7 9670 11 of of IN cord-005453-4057qib7 9670 12 the the DT cord-005453-4057qib7 9670 13 duodenum duodenum NN cord-005453-4057qib7 9670 14 and and CC cord-005453-4057qib7 9670 15 feces fece NNS cord-005453-4057qib7 9670 16 collection collection NN cord-005453-4057qib7 9670 17 , , , cord-005453-4057qib7 9670 18 with with IN cord-005453-4057qib7 9670 19 further further JJ cord-005453-4057qib7 9670 20 bacteria bacteria NNS cord-005453-4057qib7 9670 21 PCR PCR NNP cord-005453-4057qib7 9670 22 identification identification NN cord-005453-4057qib7 9670 23 . . . cord-005453-4057qib7 9671 1 Hydrogen hydrogen NN cord-005453-4057qib7 9671 2 breath breath NN cord-005453-4057qib7 9671 3 test test NN cord-005453-4057qib7 9671 4 was be VBD cord-005453-4057qib7 9671 5 performed perform VBN cord-005453-4057qib7 9671 6 also also RB cord-005453-4057qib7 9671 7 in in IN cord-005453-4057qib7 9671 8 which which WDT cord-005453-4057qib7 9671 9 patients patient NNS cord-005453-4057qib7 9671 10 were be VBD cord-005453-4057qib7 9671 11 treated treat VBN cord-005453-4057qib7 9671 12 with with IN cord-005453-4057qib7 9671 13 oral oral JJ cord-005453-4057qib7 9671 14 lactose lactose NN cord-005453-4057qib7 9671 15 2 2 CD cord-005453-4057qib7 9671 16 g g NN cord-005453-4057qib7 9671 17 / / SYM cord-005453-4057qib7 9671 18 kg kg NN cord-005453-4057qib7 9671 19 with with IN cord-005453-4057qib7 9671 20 subsequent subsequent JJ cord-005453-4057qib7 9671 21 hydrogen hydrogen NN cord-005453-4057qib7 9671 22 assessment assessment NN cord-005453-4057qib7 9671 23 after after IN cord-005453-4057qib7 9671 24 30 30 CD cord-005453-4057qib7 9671 25 and and CC cord-005453-4057qib7 9671 26 60 60 CD cord-005453-4057qib7 9671 27 minutes minute NNS cord-005453-4057qib7 9671 28 . . . cord-005453-4057qib7 9672 1 The the DT cord-005453-4057qib7 9672 2 study study NN cord-005453-4057qib7 9672 3 was be VBD cord-005453-4057qib7 9672 4 performed perform VBN cord-005453-4057qib7 9672 5 in in IN cord-005453-4057qib7 9672 6 the the DT cord-005453-4057qib7 9672 7 period period NN cord-005453-4057qib7 9672 8 from from IN cord-005453-4057qib7 9672 9 20 20 CD cord-005453-4057qib7 9672 10 to to TO cord-005453-4057qib7 9672 11 741 741 CD cord-005453-4057qib7 9672 12 days day NNS cord-005453-4057qib7 9672 13 after after IN cord-005453-4057qib7 9672 14 allo allo NN cord-005453-4057qib7 9672 15 - - HYPH cord-005453-4057qib7 9672 16 HSCT HSCT NNP cord-005453-4057qib7 9672 17 . . . cord-005453-4057qib7 9673 1 Results result NNS cord-005453-4057qib7 9673 2 : : : cord-005453-4057qib7 9674 1 According accord VBG cord-005453-4057qib7 9674 2 to to IN cord-005453-4057qib7 9674 3 feces fece NNS cord-005453-4057qib7 9674 4 analysis analysis NN cord-005453-4057qib7 9674 5 data datum NNS cord-005453-4057qib7 9674 6 , , , cord-005453-4057qib7 9674 7 colon colon NN cord-005453-4057qib7 9674 8 microbiota microbiota NN cord-005453-4057qib7 9674 9 composition composition NN cord-005453-4057qib7 9674 10 significantly significantly RB cord-005453-4057qib7 9674 11 differed differ VBD cord-005453-4057qib7 9674 12 from from IN cord-005453-4057qib7 9674 13 the the DT cord-005453-4057qib7 9674 14 reference reference NN cord-005453-4057qib7 9674 15 values value NNS cord-005453-4057qib7 9674 16 . . . cord-005453-4057qib7 9675 1 At at IN cord-005453-4057qib7 9675 2 the the DT cord-005453-4057qib7 9675 3 same same JJ cord-005453-4057qib7 9675 4 time time NN cord-005453-4057qib7 9675 5 total total JJ cord-005453-4057qib7 9675 6 bacterial bacterial JJ cord-005453-4057qib7 9675 7 mass mass NN cord-005453-4057qib7 9675 8 of of IN cord-005453-4057qib7 9675 9 the the DT cord-005453-4057qib7 9675 10 duodenum duodenum NN cord-005453-4057qib7 9675 11 was be VBD cord-005453-4057qib7 9675 12 less less JJR cord-005453-4057qib7 9675 13 in in IN cord-005453-4057qib7 9675 14 comparison comparison NN cord-005453-4057qib7 9675 15 with with IN cord-005453-4057qib7 9675 16 colon colon NN cord-005453-4057qib7 9675 17 microbiota microbiota NN cord-005453-4057qib7 9675 18 : : : cord-005453-4057qib7 9676 1 2E+08 2e+08 CD cord-005453-4057qib7 9676 2 ( ( -LRB- cord-005453-4057qib7 9676 3 2E+7/8E+9 2E+7/8E+9 NNP cord-005453-4057qib7 9676 4 ) ) -RRB- cord-005453-4057qib7 9676 5 and and CC cord-005453-4057qib7 9676 6 9E+10 9e+10 CD cord-005453-4057qib7 9676 7 ( ( -LRB- cord-005453-4057qib7 9676 8 9E+7/3E+12 9e+7/3e+12 CD cord-005453-4057qib7 9676 9 ) ) -RRB- cord-005453-4057qib7 9676 10 , , , cord-005453-4057qib7 9676 11 respectively respectively RB cord-005453-4057qib7 9676 12 ( ( -LRB- cord-005453-4057qib7 9676 13 p p NN cord-005453-4057qib7 9676 14 < < XX cord-005453-4057qib7 9676 15 0.004 0.004 CD cord-005453-4057qib7 9676 16 ) ) -RRB- cord-005453-4057qib7 9676 17 . . . cord-005453-4057qib7 9677 1 Quantitative quantitative JJ cord-005453-4057qib7 9677 2 composition composition NN cord-005453-4057qib7 9677 3 of of IN cord-005453-4057qib7 9677 4 the the DT cord-005453-4057qib7 9677 5 duodenal duodenal JJ cord-005453-4057qib7 9677 6 microbiota microbiota NN cord-005453-4057qib7 9677 7 was be VBD cord-005453-4057qib7 9677 8 comparable comparable JJ cord-005453-4057qib7 9677 9 to to IN cord-005453-4057qib7 9677 10 that that DT cord-005453-4057qib7 9677 11 of of IN cord-005453-4057qib7 9677 12 colon colon NN cord-005453-4057qib7 9677 13 : : : cord-005453-4057qib7 9678 1 Lactobacillus lactobacillus NN cord-005453-4057qib7 9678 2 spp spp NNS cord-005453-4057qib7 9678 3 . . . cord-005453-4057qib7 9678 4 4E+5 4e+5 CD cord-005453-4057qib7 9679 1 ( ( -LRB- cord-005453-4057qib7 9679 2 1E+5/2E+7 1e+5/2e+7 CD cord-005453-4057qib7 9679 3 ) ) -RRB- cord-005453-4057qib7 9679 4 > > XX cord-005453-4057qib7 9680 1 1.5 1.5 CD cord-005453-4057qib7 9680 2 E+5 e+5 JJ cord-005453-4057qib7 9680 3 ( ( -LRB- cord-005453-4057qib7 9680 4 1E+5/4E+11 1e+5/4e+11 CD cord-005453-4057qib7 9680 5 ) ) -RRB- cord-005453-4057qib7 9680 6 , , , cord-005453-4057qib7 9680 7 ( ( -LRB- cord-005453-4057qib7 9680 8 p=0.48 p=0.48 NNP cord-005453-4057qib7 9680 9 ) ) -RRB- cord-005453-4057qib7 9680 10 ; ; : cord-005453-4057qib7 9680 11 Bifidobacterium bifidobacterium NN cord-005453-4057qib7 9680 12 spp spp NNS cord-005453-4057qib7 9680 13 . . . cord-005453-4057qib7 9680 14 6E+6 6e+6 CD cord-005453-4057qib7 9681 1 ( ( -LRB- cord-005453-4057qib7 9681 2 1E+05/3E+7 1e+05/3e+7 CD cord-005453-4057qib7 9681 3 ) ) -RRB- cord-005453-4057qib7 9682 1 < < XX cord-005453-4057qib7 9683 1 7.5 7.5 CD cord-005453-4057qib7 9683 2 E+6 e+6 NN cord-005453-4057qib7 9683 3 ( ( -LRB- cord-005453-4057qib7 9683 4 2E+5/1E+9 2E+5/1E+9 NNS cord-005453-4057qib7 9683 5 ) ) -RRB- cord-005453-4057qib7 9683 6 , , , cord-005453-4057qib7 9683 7 ( ( -LRB- cord-005453-4057qib7 9683 8 p=0.423 p=0.423 NNP cord-005453-4057qib7 9683 9 ) ) -RRB- cord-005453-4057qib7 9683 10 ; ; : cord-005453-4057qib7 9683 11 Escherichia Escherichia NNP cord-005453-4057qib7 9683 12 coli coli NNS cord-005453-4057qib7 9683 13 7E+5 7e+5 CD cord-005453-4057qib7 9684 1 ( ( -LRB- cord-005453-4057qib7 9684 2 1E+5/2E+6 1e+5/2e+6 CD cord-005453-4057qib7 9684 3 ) ) -RRB- cord-005453-4057qib7 9685 1 > > XX cord-005453-4057qib7 9686 1 5E+5 5e+5 LS cord-005453-4057qib7 9687 1 ( ( -LRB- cord-005453-4057qib7 9687 2 4E+5/9E+5 4e+5/9e+5 LS cord-005453-4057qib7 9687 3 ) ) -RRB- cord-005453-4057qib7 9687 4 , , , cord-005453-4057qib7 9687 5 ( ( -LRB- cord-005453-4057qib7 9687 6 p=0.2 p=0.2 NNP cord-005453-4057qib7 9687 7 ) ) -RRB- cord-005453-4057qib7 9687 8 ; ; : cord-005453-4057qib7 9687 9 Bacteroides Bacteroides NNP cord-005453-4057qib7 9687 10 fragilis fragilis NN cord-005453-4057qib7 9687 11 group group NN cord-005453-4057qib7 9687 12 6E+6 6e+6 CD cord-005453-4057qib7 9687 13 ( ( -LRB- cord-005453-4057qib7 9687 14 0E+0/8E+9 0e+0/8e+9 NN cord-005453-4057qib7 9687 15 ) ) -RRB- cord-005453-4057qib7 9688 1 > > XX cord-005453-4057qib7 9688 2 5E+6 5e+6 CD cord-005453-4057qib7 9688 3 ( ( -LRB- cord-005453-4057qib7 9688 4 2E+5/3E 2E+5/3E NNP cord-005453-4057qib7 9688 5 +12 +12 NNP cord-005453-4057qib7 9688 6 ) ) -RRB- cord-005453-4057qib7 9688 7 , , , cord-005453-4057qib7 9688 8 ( ( -LRB- cord-005453-4057qib7 9688 9 p=1.0 p=1.0 NNP cord-005453-4057qib7 9688 10 ) ) -RRB- cord-005453-4057qib7 9688 11 ; ; : cord-005453-4057qib7 9688 12 Faecalibacterium Faecalibacterium NNP cord-005453-4057qib7 9688 13 prausnitzii prausnitzii NN cord-005453-4057qib7 9688 14 1E+6 1e+6 CD cord-005453-4057qib7 9688 15 ( ( -LRB- cord-005453-4057qib7 9688 16 0E+0/ 0e+0/ CD cord-005453-4057qib7 9688 17 1E+7 1e+7 CD cord-005453-4057qib7 9688 18 ) ) -RRB- cord-005453-4057qib7 9689 1 < < XX cord-005453-4057qib7 9690 1 1.5 1.5 CD cord-005453-4057qib7 9690 2 E+6 e+6 NN cord-005453-4057qib7 9690 3 ( ( -LRB- cord-005453-4057qib7 9690 4 1E+5/3E+10 1e+5/3e+10 CD cord-005453-4057qib7 9690 5 ) ) -RRB- cord-005453-4057qib7 9690 6 , , , cord-005453-4057qib7 9690 7 ( ( -LRB- cord-005453-4057qib7 9690 8 p=0.54 p=0.54 NNP cord-005453-4057qib7 9690 9 ) ) -RRB- cord-005453-4057qib7 9690 10 , , , cord-005453-4057qib7 9690 11 indicating indicate VBG cord-005453-4057qib7 9690 12 the the DT cord-005453-4057qib7 9690 13 presence presence NN cord-005453-4057qib7 9690 14 of of IN cord-005453-4057qib7 9690 15 SIBO SIBO NNP cord-005453-4057qib7 9690 16 . . . cord-005453-4057qib7 9691 1 In in IN cord-005453-4057qib7 9691 2 this this DT cord-005453-4057qib7 9691 3 case case NN cord-005453-4057qib7 9691 4 , , , cord-005453-4057qib7 9691 5 the the DT cord-005453-4057qib7 9691 6 hydrogen hydrogen NN cord-005453-4057qib7 9691 7 breath breath NN cord-005453-4057qib7 9691 8 test test NN cord-005453-4057qib7 9691 9 was be VBD cord-005453-4057qib7 9691 10 completely completely RB cord-005453-4057qib7 9691 11 uninformative uninformative JJ cord-005453-4057qib7 9691 12 : : : cord-005453-4057qib7 9691 13 basal basal JJ cord-005453-4057qib7 9691 14 values value NNS cord-005453-4057qib7 9691 15 -0.035 -0.035 NNP cord-005453-4057qib7 9692 1 ( ( -LRB- cord-005453-4057qib7 9692 2 0.01/0.06 0.01/0.06 NNP cord-005453-4057qib7 9692 3 ) ) -RRB- cord-005453-4057qib7 9693 1 ppm ppm NN cord-005453-4057qib7 9693 2 , , , cord-005453-4057qib7 9693 3 hydrogen hydrogen NN cord-005453-4057qib7 9693 4 concentration concentration NN cord-005453-4057qib7 9693 5 in in IN cord-005453-4057qib7 9693 6 30 30 CD cord-005453-4057qib7 9693 7 minutes minute NNS cord-005453-4057qib7 9693 8 -0.04 -0.04 CD cord-005453-4057qib7 9693 9 ( ( -LRB- cord-005453-4057qib7 9693 10 0.01/ 0.01/ CD cord-005453-4057qib7 9693 11 0.06 0.06 CD cord-005453-4057qib7 9693 12 ) ) -RRB- cord-005453-4057qib7 9694 1 ppm ppm NN cord-005453-4057qib7 9694 2 , , , cord-005453-4057qib7 9694 3 in in IN cord-005453-4057qib7 9694 4 60 60 CD cord-005453-4057qib7 9694 5 minutes minute NNS cord-005453-4057qib7 9694 6 -0.02 -0.02 CD cord-005453-4057qib7 9694 7 ( ( -LRB- cord-005453-4057qib7 9694 8 0.01/0.07 0.01/0.07 CD cord-005453-4057qib7 9694 9 ) ) -RRB- cord-005453-4057qib7 9694 10 ppm ppm NN cord-005453-4057qib7 9694 11 , , , cord-005453-4057qib7 9694 12 which which WDT cord-005453-4057qib7 9694 13 is be VBZ cord-005453-4057qib7 9694 14 less less JJR cord-005453-4057qib7 9694 15 than than IN cord-005453-4057qib7 9694 16 in in IN cord-005453-4057qib7 9694 17 healthy healthy JJ cord-005453-4057qib7 9694 18 volunteers volunteer NNS cord-005453-4057qib7 9694 19 . . . cord-005453-4057qib7 9695 1 Conclusions conclusion NNS cord-005453-4057qib7 9695 2 : : : cord-005453-4057qib7 9696 1 Quantitative quantitative JJ cord-005453-4057qib7 9696 2 composition composition NN cord-005453-4057qib7 9696 3 of of IN cord-005453-4057qib7 9696 4 the the DT cord-005453-4057qib7 9696 5 duodenal duodenal NN cord-005453-4057qib7 9696 6 and and CC cord-005453-4057qib7 9696 7 colon colon NN cord-005453-4057qib7 9696 8 microbiota microbiota NN cord-005453-4057qib7 9696 9 is be VBZ cord-005453-4057qib7 9696 10 similar similar JJ cord-005453-4057qib7 9696 11 in in IN cord-005453-4057qib7 9696 12 the the DT cord-005453-4057qib7 9696 13 case case NN cord-005453-4057qib7 9696 14 of of IN cord-005453-4057qib7 9696 15 intestinal intestinal JJ cord-005453-4057qib7 9696 16 GvHD gvhd NN cord-005453-4057qib7 9696 17 and/or and/or CC cord-005453-4057qib7 9696 18 virus virus NN cord-005453-4057qib7 9696 19 - - HYPH cord-005453-4057qib7 9696 20 associated associate VBN cord-005453-4057qib7 9696 21 enteropathy enteropathy NNP cord-005453-4057qib7 9696 22 in in IN cord-005453-4057qib7 9696 23 allo allo NN cord-005453-4057qib7 9696 24 - - HYPH cord-005453-4057qib7 9696 25 HSCT HSCT NNP cord-005453-4057qib7 9696 26 patients patient NNS cord-005453-4057qib7 9696 27 , , , cord-005453-4057qib7 9696 28 which which WDT cord-005453-4057qib7 9696 29 may may MD cord-005453-4057qib7 9696 30 be be VB cord-005453-4057qib7 9696 31 of of IN cord-005453-4057qib7 9696 32 diagnostic diagnostic JJ cord-005453-4057qib7 9696 33 value value NN cord-005453-4057qib7 9696 34 for for IN cord-005453-4057qib7 9696 35 SIBO SIBO NNP cord-005453-4057qib7 9696 36 confirmation confirmation NN cord-005453-4057qib7 9696 37 . . . cord-005453-4057qib7 9697 1 The the DT cord-005453-4057qib7 9697 2 hydrogen hydrogen NN cord-005453-4057qib7 9697 3 breath breath NN cord-005453-4057qib7 9697 4 test test NN cord-005453-4057qib7 9697 5 is be VBZ cord-005453-4057qib7 9697 6 an an DT cord-005453-4057qib7 9697 7 uninformative uninformative JJ cord-005453-4057qib7 9697 8 method method NN cord-005453-4057qib7 9697 9 for for IN cord-005453-4057qib7 9697 10 SIBO SIBO NNP cord-005453-4057qib7 9697 11 identification identification NN cord-005453-4057qib7 9697 12 in in IN cord-005453-4057qib7 9697 13 patients patient NNS cord-005453-4057qib7 9697 14 after after IN cord-005453-4057qib7 9697 15 allo allo NN cord-005453-4057qib7 9697 16 - - HYPH cord-005453-4057qib7 9697 17 HSCT HSCT NNP cord-005453-4057qib7 9697 18 . . . cord-005453-4057qib7 9698 1 Disclosure disclosure NN cord-005453-4057qib7 9698 2 : : : cord-005453-4057qib7 9698 3 Nothing nothing NN cord-005453-4057qib7 9698 4 to to TO cord-005453-4057qib7 9698 5 declare declare VB cord-005453-4057qib7 9698 6 Johannes Johannes NNP cord-005453-4057qib7 9698 7 Schulte Schulte NNP cord-005453-4057qib7 9698 8 1 1 CD cord-005453-4057qib7 9698 9 , , , cord-005453-4057qib7 9698 10 Patrick Patrick NNP cord-005453-4057qib7 9698 11 Hundsdörfer Hundsdörfer NNP cord-005453-4057qib7 9698 12 1 1 CD cord-005453-4057qib7 9698 13 , , , cord-005453-4057qib7 9698 14 Sebastian Sebastian NNP cord-005453-4057qib7 9698 15 Voigt Voigt NNP cord-005453-4057qib7 9698 16 1 1 CD cord-005453-4057qib7 9698 17 Background Background NNP cord-005453-4057qib7 9698 18 : : : cord-005453-4057qib7 9698 19 Adenovirus Adenovirus NNP cord-005453-4057qib7 9698 20 ( ( -LRB- cord-005453-4057qib7 9698 21 AdV adv NN cord-005453-4057qib7 9698 22 ) ) -RRB- cord-005453-4057qib7 9698 23 infections infection NNS cord-005453-4057qib7 9698 24 or or CC cord-005453-4057qib7 9698 25 reactivations reactivation NNS cord-005453-4057qib7 9698 26 frequently frequently RB cord-005453-4057qib7 9698 27 occur occur VBP cord-005453-4057qib7 9698 28 in in IN cord-005453-4057qib7 9698 29 the the DT cord-005453-4057qib7 9698 30 pediatric pediatric JJ cord-005453-4057qib7 9698 31 hematopoietic hematopoietic JJ cord-005453-4057qib7 9698 32 stem stem NN cord-005453-4057qib7 9698 33 cell cell NN cord-005453-4057qib7 9698 34 transplant transplant NN cord-005453-4057qib7 9698 35 ( ( -LRB- cord-005453-4057qib7 9698 36 SCT SCT NNP cord-005453-4057qib7 9698 37 ) ) -RRB- cord-005453-4057qib7 9698 38 setting setting NN cord-005453-4057qib7 9698 39 and and CC cord-005453-4057qib7 9698 40 these these DT cord-005453-4057qib7 9698 41 infections infection NNS cord-005453-4057qib7 9698 42 contribute contribute VBP cord-005453-4057qib7 9698 43 to to IN cord-005453-4057qib7 9698 44 increased increase VBN cord-005453-4057qib7 9698 45 morbidity morbidity NN cord-005453-4057qib7 9698 46 and and CC cord-005453-4057qib7 9698 47 mortality mortality NN cord-005453-4057qib7 9698 48 . . . cord-005453-4057qib7 9699 1 The the DT cord-005453-4057qib7 9699 2 nucleotide nucleotide JJ cord-005453-4057qib7 9699 3 analog analog NN cord-005453-4057qib7 9699 4 Cidofovir Cidofovir NNP cord-005453-4057qib7 9699 5 might may MD cord-005453-4057qib7 9699 6 be be VB cord-005453-4057qib7 9699 7 effective effective JJ cord-005453-4057qib7 9699 8 in in IN cord-005453-4057qib7 9699 9 reducing reduce VBG cord-005453-4057qib7 9699 10 AdV adv NN cord-005453-4057qib7 9699 11 load load NN cord-005453-4057qib7 9699 12 , , , cord-005453-4057qib7 9699 13 however however RB cord-005453-4057qib7 9699 14 , , , cord-005453-4057qib7 9699 15 nephrotoxicity nephrotoxicity NNP cord-005453-4057qib7 9699 16 is be VBZ cord-005453-4057qib7 9699 17 a a DT cord-005453-4057qib7 9699 18 considerable considerable JJ cord-005453-4057qib7 9699 19 side side NN cord-005453-4057qib7 9699 20 effect effect NN cord-005453-4057qib7 9699 21 . . . cord-005453-4057qib7 9700 1 The the DT cord-005453-4057qib7 9700 2 new new JJ cord-005453-4057qib7 9700 3 antiviral antiviral JJ cord-005453-4057qib7 9700 4 compound compound NN cord-005453-4057qib7 9700 5 Brincidofovir Brincidofovir NNP cord-005453-4057qib7 9700 6 ( ( -LRB- cord-005453-4057qib7 9700 7 BCV BCV NNP cord-005453-4057qib7 9700 8 , , , cord-005453-4057qib7 9700 9 CMX-001 cmx-001 PRP cord-005453-4057qib7 9700 10 ) ) -RRB- cord-005453-4057qib7 9700 11 , , , cord-005453-4057qib7 9700 12 a a DT cord-005453-4057qib7 9700 13 lipid lipid NN cord-005453-4057qib7 9700 14 - - HYPH cord-005453-4057qib7 9700 15 conjugate conjugate NN cord-005453-4057qib7 9700 16 nucleotide nucleotide JJ cord-005453-4057qib7 9700 17 analog analog NN cord-005453-4057qib7 9700 18 with with IN cord-005453-4057qib7 9700 19 broad broad JJ cord-005453-4057qib7 9700 20 - - HYPH cord-005453-4057qib7 9700 21 spectrum spectrum NN cord-005453-4057qib7 9700 22 antiviral antiviral JJ cord-005453-4057qib7 9700 23 activity activity NN cord-005453-4057qib7 9700 24 in in IN cord-005453-4057qib7 9700 25 vitro vitro FW cord-005453-4057qib7 9700 26 , , , cord-005453-4057qib7 9700 27 has have VBZ cord-005453-4057qib7 9700 28 been be VBN cord-005453-4057qib7 9700 29 reported report VBN cord-005453-4057qib7 9700 30 to to TO cord-005453-4057qib7 9700 31 be be VB cord-005453-4057qib7 9700 32 effective effective JJ cord-005453-4057qib7 9700 33 in in IN cord-005453-4057qib7 9700 34 cases case NNS cord-005453-4057qib7 9700 35 where where WRB cord-005453-4057qib7 9700 36 Cidofovir Cidofovir NNP cord-005453-4057qib7 9700 37 treatment treatment NN cord-005453-4057qib7 9700 38 was be VBD cord-005453-4057qib7 9700 39 unsuccessful unsuccessful JJ cord-005453-4057qib7 9700 40 . . . cord-005453-4057qib7 9701 1 Methods method NNS cord-005453-4057qib7 9701 2 : : : cord-005453-4057qib7 9701 3 Data datum NNS cord-005453-4057qib7 9701 4 of of IN cord-005453-4057qib7 9701 5 eight eight CD cord-005453-4057qib7 9701 6 pediatric pediatric JJ cord-005453-4057qib7 9701 7 patients patient NNS cord-005453-4057qib7 9701 8 undergoing undergo VBG cord-005453-4057qib7 9701 9 SCT SCT NNP cord-005453-4057qib7 9701 10 for for IN cord-005453-4057qib7 9701 11 malignant malignant JJ cord-005453-4057qib7 9701 12 and and CC cord-005453-4057qib7 9701 13 nonmalignant nonmalignant JJ cord-005453-4057qib7 9701 14 indications indication NNS cord-005453-4057qib7 9701 15 were be VBD cord-005453-4057qib7 9701 16 analyzed analyze VBN cord-005453-4057qib7 9701 17 . . . cord-005453-4057qib7 9702 1 All all DT cord-005453-4057qib7 9702 2 patients patient NNS cord-005453-4057qib7 9702 3 were be VBD cord-005453-4057qib7 9702 4 weekly weekly RB cord-005453-4057qib7 9702 5 monitored monitor VBN cord-005453-4057qib7 9702 6 for for IN cord-005453-4057qib7 9702 7 AdV adv NN cord-005453-4057qib7 9702 8 viremia viremia NN cord-005453-4057qib7 9702 9 by by IN cord-005453-4057qib7 9702 10 PCR PCR NNP cord-005453-4057qib7 9702 11 . . . cord-005453-4057qib7 9703 1 In in IN cord-005453-4057qib7 9703 2 case case NN cord-005453-4057qib7 9703 3 two two CD cord-005453-4057qib7 9703 4 consecutive consecutive JJ cord-005453-4057qib7 9703 5 positive positive JJ cord-005453-4057qib7 9703 6 AdV adv NN cord-005453-4057qib7 9703 7 PCR PCR NNP cord-005453-4057qib7 9703 8 results result NNS cord-005453-4057qib7 9703 9 indicating indicate VBG cord-005453-4057qib7 9703 10 a a DT cord-005453-4057qib7 9703 11 viral viral JJ cord-005453-4057qib7 9703 12 copy copy NN cord-005453-4057qib7 9703 13 number number NN cord-005453-4057qib7 9703 14 > > XX cord-005453-4057qib7 9704 1 1000 1000 CD cord-005453-4057qib7 9704 2 / / SYM cord-005453-4057qib7 9704 3 ml ml NNS cord-005453-4057qib7 9704 4 were be VBD cord-005453-4057qib7 9704 5 documented document VBN cord-005453-4057qib7 9704 6 , , , cord-005453-4057qib7 9704 7 patients patient NNS cord-005453-4057qib7 9704 8 received receive VBD cord-005453-4057qib7 9704 9 a a DT cord-005453-4057qib7 9704 10 weekly weekly JJ cord-005453-4057qib7 9704 11 dose dose NN cord-005453-4057qib7 9704 12 of of IN cord-005453-4057qib7 9704 13 Cidofovir Cidofovir NNP cord-005453-4057qib7 9704 14 . . . cord-005453-4057qib7 9705 1 If if IN cord-005453-4057qib7 9705 2 no no DT cord-005453-4057qib7 9705 3 reduction reduction NN cord-005453-4057qib7 9705 4 of of IN cord-005453-4057qib7 9705 5 AdV adv NN cord-005453-4057qib7 9705 6 load load NN cord-005453-4057qib7 9705 7 was be VBD cord-005453-4057qib7 9705 8 seen see VBN cord-005453-4057qib7 9705 9 within within IN cord-005453-4057qib7 9705 10 two two CD cord-005453-4057qib7 9705 11 weeks week NNS cord-005453-4057qib7 9705 12 after after IN cord-005453-4057qib7 9705 13 the the DT cord-005453-4057qib7 9705 14 commencement commencement NN cord-005453-4057qib7 9705 15 of of IN cord-005453-4057qib7 9705 16 treatment treatment NN cord-005453-4057qib7 9705 17 or or CC cord-005453-4057qib7 9705 18 side side NN cord-005453-4057qib7 9705 19 effects effect NNS cord-005453-4057qib7 9705 20 demanded demand VBD cord-005453-4057qib7 9705 21 Cidofovir Cidofovir NNP cord-005453-4057qib7 9705 22 discontinuation discontinuation NN cord-005453-4057qib7 9705 23 , , , cord-005453-4057qib7 9705 24 BCV BCV NNP cord-005453-4057qib7 9705 25 was be VBD cord-005453-4057qib7 9705 26 obtained obtain VBN cord-005453-4057qib7 9705 27 through through IN cord-005453-4057qib7 9705 28 an an DT cord-005453-4057qib7 9705 29 emergency emergency NN cord-005453-4057qib7 9705 30 expanded expand VBN cord-005453-4057qib7 9705 31 access access NN cord-005453-4057qib7 9705 32 programme programme NN cord-005453-4057qib7 9705 33 . . . cord-005453-4057qib7 9706 1 Results result NNS cord-005453-4057qib7 9706 2 : : : cord-005453-4057qib7 9707 1 Eight eight CD cord-005453-4057qib7 9707 2 pediatric pediatric JJ cord-005453-4057qib7 9707 3 patients patient NNS cord-005453-4057qib7 9707 4 developed develop VBD cord-005453-4057qib7 9707 5 AdV adv NN cord-005453-4057qib7 9707 6 viremia viremia NN cord-005453-4057qib7 9707 7 with with IN cord-005453-4057qib7 9707 8 maximum maximum JJ cord-005453-4057qib7 9707 9 viral viral JJ cord-005453-4057qib7 9707 10 loads load NNS cord-005453-4057qib7 9707 11 ranging range VBG cord-005453-4057qib7 9707 12 between between IN cord-005453-4057qib7 9707 13 9350 9350 CD cord-005453-4057qib7 9707 14 and and CC cord-005453-4057qib7 9707 15 4430000 4430000 CD cord-005453-4057qib7 9707 16 copies copy NNS cord-005453-4057qib7 9707 17 / / SYM cord-005453-4057qib7 9707 18 ml ml NN cord-005453-4057qib7 9707 19 . . . cord-005453-4057qib7 9708 1 Six six CD cord-005453-4057qib7 9708 2 patients patient NNS cord-005453-4057qib7 9708 3 had have VBD cord-005453-4057qib7 9708 4 C c NN cord-005453-4057qib7 9708 5 type type NN cord-005453-4057qib7 9708 6 AdV adv NN cord-005453-4057qib7 9708 7 and and CC cord-005453-4057qib7 9708 8 two two CD cord-005453-4057qib7 9708 9 patients patient NNS cord-005453-4057qib7 9708 10 had have VBD cord-005453-4057qib7 9708 11 non non AFX cord-005453-4057qib7 9708 12 C c NN cord-005453-4057qib7 9708 13 type type NN cord-005453-4057qib7 9708 14 AdV adv NN cord-005453-4057qib7 9708 15 infections infection NNS cord-005453-4057qib7 9708 16 . . . cord-005453-4057qib7 9709 1 Five five CD cord-005453-4057qib7 9709 2 patients patient NNS cord-005453-4057qib7 9709 3 had have VBD cord-005453-4057qib7 9709 4 viral viral JJ cord-005453-4057qib7 9709 5 co co NNS cord-005453-4057qib7 9709 6 - - NNS cord-005453-4057qib7 9709 7 infections infection NNS cord-005453-4057qib7 9709 8 : : : cord-005453-4057qib7 9709 9 two two CD cord-005453-4057qib7 9709 10 had have VBD cord-005453-4057qib7 9709 11 an an DT cord-005453-4057qib7 9709 12 additional additional JJ cord-005453-4057qib7 9709 13 CMV CMV NNP cord-005453-4057qib7 9709 14 infection infection NN cord-005453-4057qib7 9709 15 , , , cord-005453-4057qib7 9709 16 one one PRP cord-005453-4057qib7 9709 17 had have VBD cord-005453-4057qib7 9709 18 an an DT cord-005453-4057qib7 9709 19 Epstein Epstein NNP cord-005453-4057qib7 9709 20 - - HYPH cord-005453-4057qib7 9709 21 Barr Barr NNP cord-005453-4057qib7 9709 22 virus virus NN cord-005453-4057qib7 9709 23 ( ( -LRB- cord-005453-4057qib7 9709 24 EBV EBV NNP cord-005453-4057qib7 9709 25 ) ) -RRB- cord-005453-4057qib7 9709 26 and and CC cord-005453-4057qib7 9709 27 Herpes Herpes NNP cord-005453-4057qib7 9709 28 simplex simplex NN cord-005453-4057qib7 9709 29 virus virus NN cord-005453-4057qib7 9709 30 co co NN cord-005453-4057qib7 9709 31 - - NN cord-005453-4057qib7 9709 32 infection infection NN cord-005453-4057qib7 9709 33 , , , cord-005453-4057qib7 9709 34 one one CD cord-005453-4057qib7 9709 35 patient patient NN cord-005453-4057qib7 9709 36 had have VBD cord-005453-4057qib7 9709 37 an an DT cord-005453-4057qib7 9709 38 EBV EBV NNP cord-005453-4057qib7 9709 39 co co NN cord-005453-4057qib7 9709 40 - - NN cord-005453-4057qib7 9709 41 infection infection NN cord-005453-4057qib7 9709 42 and and CC cord-005453-4057qib7 9709 43 one one CD cord-005453-4057qib7 9709 44 patient patient NN cord-005453-4057qib7 9709 45 had have VBD cord-005453-4057qib7 9709 46 a a DT cord-005453-4057qib7 9709 47 BK BK NNP cord-005453-4057qib7 9709 48 virus virus NN cord-005453-4057qib7 9709 49 co co NN cord-005453-4057qib7 9709 50 - - NN cord-005453-4057qib7 9709 51 infection infection NN cord-005453-4057qib7 9709 52 . . . cord-005453-4057qib7 9710 1 All all DT cord-005453-4057qib7 9710 2 eight eight CD cord-005453-4057qib7 9710 3 patients patient NNS cord-005453-4057qib7 9710 4 initially initially RB cord-005453-4057qib7 9710 5 received receive VBD cord-005453-4057qib7 9710 6 Cidofovir Cidofovir NNP cord-005453-4057qib7 9710 7 , , , cord-005453-4057qib7 9710 8 however however RB cord-005453-4057qib7 9710 9 , , , cord-005453-4057qib7 9710 10 a a DT cord-005453-4057qib7 9710 11 substantial substantial JJ cord-005453-4057qib7 9710 12 decrease decrease NN cord-005453-4057qib7 9710 13 in in IN cord-005453-4057qib7 9710 14 AdV adv NN cord-005453-4057qib7 9710 15 load load NN cord-005453-4057qib7 9710 16 could could MD cord-005453-4057qib7 9710 17 not not RB cord-005453-4057qib7 9710 18 be be VB cord-005453-4057qib7 9710 19 observed observe VBN cord-005453-4057qib7 9710 20 in in IN cord-005453-4057qib7 9710 21 any any DT cord-005453-4057qib7 9710 22 patient patient NN cord-005453-4057qib7 9710 23 after after IN cord-005453-4057qib7 9710 24 a a DT cord-005453-4057qib7 9710 25 two two CD cord-005453-4057qib7 9710 26 - - HYPH cord-005453-4057qib7 9710 27 week week NN cord-005453-4057qib7 9710 28 administration administration NN cord-005453-4057qib7 9710 29 course course NN cord-005453-4057qib7 9710 30 . . . cord-005453-4057qib7 9711 1 Except except IN cord-005453-4057qib7 9711 2 in in IN cord-005453-4057qib7 9711 3 one one CD cord-005453-4057qib7 9711 4 patient patient NN cord-005453-4057qib7 9711 5 who who WP cord-005453-4057qib7 9711 6 had have VBD cord-005453-4057qib7 9711 7 extensive extensive JJ cord-005453-4057qib7 9711 8 intestinal intestinal JJ cord-005453-4057qib7 9711 9 graft graft NN cord-005453-4057qib7 9711 10 - - HYPH cord-005453-4057qib7 9711 11 versus versus IN cord-005453-4057qib7 9711 12 host host NN cord-005453-4057qib7 9711 13 disease disease NN cord-005453-4057qib7 9711 14 ( ( -LRB- cord-005453-4057qib7 9711 15 GvHD GvHD NNP cord-005453-4057qib7 9711 16 ) ) -RRB- cord-005453-4057qib7 9711 17 , , , cord-005453-4057qib7 9711 18 AdV adv NN cord-005453-4057qib7 9711 19 infection infection NN cord-005453-4057qib7 9711 20 was be VBD cord-005453-4057qib7 9711 21 cleared clear VBN cord-005453-4057qib7 9711 22 in in IN cord-005453-4057qib7 9711 23 all all DT cord-005453-4057qib7 9711 24 patients patient NNS cord-005453-4057qib7 9711 25 within within IN cord-005453-4057qib7 9711 26 three three CD cord-005453-4057qib7 9711 27 weeks week NNS cord-005453-4057qib7 9711 28 after after IN cord-005453-4057qib7 9711 29 the the DT cord-005453-4057qib7 9711 30 beginning beginning NN cord-005453-4057qib7 9711 31 of of IN cord-005453-4057qib7 9711 32 BCV BCV NNP cord-005453-4057qib7 9711 33 treatment treatment NN cord-005453-4057qib7 9711 34 . . . cord-005453-4057qib7 9712 1 In in IN cord-005453-4057qib7 9712 2 addition addition NN cord-005453-4057qib7 9712 3 , , , cord-005453-4057qib7 9712 4 all all DT cord-005453-4057qib7 9712 5 coinfections coinfection NNS cord-005453-4057qib7 9712 6 were be VBD cord-005453-4057qib7 9712 7 cleared clear VBN cord-005453-4057qib7 9712 8 . . . cord-005453-4057qib7 9713 1 No no DT cord-005453-4057qib7 9713 2 nephrotoxicity nephrotoxicity NN cord-005453-4057qib7 9713 3 or or CC cord-005453-4057qib7 9713 4 other other JJ cord-005453-4057qib7 9713 5 side side NN cord-005453-4057qib7 9713 6 effects effect NNS cord-005453-4057qib7 9713 7 were be VBD cord-005453-4057qib7 9713 8 observed observe VBN cord-005453-4057qib7 9713 9 . . . cord-005453-4057qib7 9714 1 Conclusions conclusion NNS cord-005453-4057qib7 9714 2 : : : cord-005453-4057qib7 9715 1 BCV BCV NNP cord-005453-4057qib7 9715 2 was be VBD cord-005453-4057qib7 9715 3 effective effective JJ cord-005453-4057qib7 9715 4 in in IN cord-005453-4057qib7 9715 5 all all DT cord-005453-4057qib7 9715 6 but but IN cord-005453-4057qib7 9715 7 one one CD cord-005453-4057qib7 9715 8 patient patient NN cord-005453-4057qib7 9715 9 . . . cord-005453-4057qib7 9716 1 Oral oral JJ cord-005453-4057qib7 9716 2 BCV BCV NNP cord-005453-4057qib7 9716 3 might may MD cord-005453-4057qib7 9716 4 not not RB cord-005453-4057qib7 9716 5 be be VB cord-005453-4057qib7 9716 6 effective effective JJ cord-005453-4057qib7 9716 7 in in IN cord-005453-4057qib7 9716 8 advanced advanced JJ cord-005453-4057qib7 9716 9 upper upper JJ cord-005453-4057qib7 9716 10 gut gut NN cord-005453-4057qib7 9716 11 GvHD GvHD NNP cord-005453-4057qib7 9716 12 , , , cord-005453-4057qib7 9716 13 especially especially RB cord-005453-4057qib7 9716 14 when when WRB cord-005453-4057qib7 9716 15 applied apply VBN cord-005453-4057qib7 9716 16 via via IN cord-005453-4057qib7 9716 17 a a DT cord-005453-4057qib7 9716 18 gastric gastric JJ cord-005453-4057qib7 9716 19 tube tube NN cord-005453-4057qib7 9716 20 , , , cord-005453-4057qib7 9716 21 yet yet CC cord-005453-4057qib7 9716 22 this this DT cord-005453-4057qib7 9716 23 was be VBD cord-005453-4057qib7 9716 24 observed observe VBN cord-005453-4057qib7 9716 25 in in IN cord-005453-4057qib7 9716 26 only only RB cord-005453-4057qib7 9716 27 one one CD cord-005453-4057qib7 9716 28 patient patient NN cord-005453-4057qib7 9716 29 . . . cord-005453-4057qib7 9717 1 Eventually eventually RB cord-005453-4057qib7 9717 2 , , , cord-005453-4057qib7 9717 3 without without IN cord-005453-4057qib7 9717 4 nephrotoxic nephrotoxic NNP cord-005453-4057qib7 9717 5 side side NN cord-005453-4057qib7 9717 6 effects effect NNS cord-005453-4057qib7 9717 7 , , , cord-005453-4057qib7 9717 8 BCV BCV NNP cord-005453-4057qib7 9717 9 could could MD cord-005453-4057qib7 9717 10 be be VB cord-005453-4057qib7 9717 11 an an DT cord-005453-4057qib7 9717 12 useful useful JJ cord-005453-4057qib7 9717 13 alternative alternative NN cord-005453-4057qib7 9717 14 to to IN cord-005453-4057qib7 9717 15 Cidofovir Cidofovir NNP cord-005453-4057qib7 9717 16 . . . cord-005453-4057qib7 9718 1 Disclosure disclosure NN cord-005453-4057qib7 9718 2 : : : cord-005453-4057qib7 9718 3 Nothing nothing NN cord-005453-4057qib7 9718 4 to to TO cord-005453-4057qib7 9718 5 declare declare VB cord-005453-4057qib7 9718 6 . . . cord-005453-4057qib7 9719 1 Background background NN cord-005453-4057qib7 9719 2 : : : cord-005453-4057qib7 9720 1 The the DT cord-005453-4057qib7 9720 2 use use NN cord-005453-4057qib7 9720 3 of of IN cord-005453-4057qib7 9720 4 post post JJ cord-005453-4057qib7 9720 5 - - JJ cord-005453-4057qib7 9720 6 transplant transplant JJ cord-005453-4057qib7 9720 7 high high JJ cord-005453-4057qib7 9720 8 - - HYPH cord-005453-4057qib7 9720 9 dose dose NN cord-005453-4057qib7 9720 10 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 9720 11 ( ( -LRB- cord-005453-4057qib7 9720 12 PTCY PTCY NNP cord-005453-4057qib7 9720 13 ) ) -RRB- cord-005453-4057qib7 9720 14 has have VBZ cord-005453-4057qib7 9720 15 overcome overcome VBN cord-005453-4057qib7 9720 16 the the DT cord-005453-4057qib7 9720 17 need need NN cord-005453-4057qib7 9720 18 for for IN cord-005453-4057qib7 9720 19 extensive extensive JJ cord-005453-4057qib7 9720 20 depletion depletion NN cord-005453-4057qib7 9720 21 of of IN cord-005453-4057qib7 9720 22 T t NN cord-005453-4057qib7 9720 23 lymphocytes lymphocyte NNS cord-005453-4057qib7 9720 24 from from IN cord-005453-4057qib7 9720 25 haploidentical haploidentical JJ cord-005453-4057qib7 9720 26 donor donor NN cord-005453-4057qib7 9720 27 grafts graft NNS cord-005453-4057qib7 9720 28 , , , cord-005453-4057qib7 9720 29 which which WDT cord-005453-4057qib7 9720 30 traditionally traditionally RB cord-005453-4057qib7 9720 31 resulted result VBD cord-005453-4057qib7 9720 32 in in IN cord-005453-4057qib7 9720 33 severe severe JJ cord-005453-4057qib7 9720 34 and and CC cord-005453-4057qib7 9720 35 prolonged prolonged JJ cord-005453-4057qib7 9720 36 immunosuppression immunosuppression NN cord-005453-4057qib7 9720 37 . . . cord-005453-4057qib7 9721 1 However however RB cord-005453-4057qib7 9721 2 , , , cord-005453-4057qib7 9721 3 reconstitution reconstitution NN cord-005453-4057qib7 9721 4 of of IN cord-005453-4057qib7 9721 5 cellular cellular JJ cord-005453-4057qib7 9721 6 immunity immunity NN cord-005453-4057qib7 9721 7 may may MD cord-005453-4057qib7 9721 8 be be VB cord-005453-4057qib7 9721 9 delayed delay VBN cord-005453-4057qib7 9721 10 even even RB cord-005453-4057qib7 9721 11 after after IN cord-005453-4057qib7 9721 12 T t NN cord-005453-4057qib7 9721 13 cell cell NN cord-005453-4057qib7 9721 14 replete replete JJ cord-005453-4057qib7 9721 15 haploidentical haploidentical JJ cord-005453-4057qib7 9721 16 stem stem NN cord-005453-4057qib7 9721 17 cell cell NN cord-005453-4057qib7 9721 18 transplantation transplantation NN cord-005453-4057qib7 9721 19 ( ( -LRB- cord-005453-4057qib7 9721 20 haplo haplo NNP cord-005453-4057qib7 9721 21 - - HYPH cord-005453-4057qib7 9721 22 SCT SCT NNP cord-005453-4057qib7 9721 23 ) ) -RRB- cord-005453-4057qib7 9721 24 with with IN cord-005453-4057qib7 9721 25 PTCY PTCY NNP cord-005453-4057qib7 9721 26 . . . cord-005453-4057qib7 9722 1 The the DT cord-005453-4057qib7 9722 2 study study NN cord-005453-4057qib7 9722 3 of of IN cord-005453-4057qib7 9722 4 the the DT cord-005453-4057qib7 9722 5 incidence incidence NN cord-005453-4057qib7 9722 6 and and CC cord-005453-4057qib7 9722 7 severity severity NN cord-005453-4057qib7 9722 8 of of IN cord-005453-4057qib7 9722 9 viral viral JJ cord-005453-4057qib7 9722 10 reactivation reactivation NN cord-005453-4057qib7 9722 11 is be VBZ cord-005453-4057qib7 9722 12 therefore therefore RB cord-005453-4057qib7 9722 13 relevant relevant JJ cord-005453-4057qib7 9722 14 to to IN cord-005453-4057qib7 9722 15 the the DT cord-005453-4057qib7 9722 16 outcomes outcome NNS cord-005453-4057qib7 9722 17 of of IN cord-005453-4057qib7 9722 18 haplo haplo NNP cord-005453-4057qib7 9722 19 - - HYPH cord-005453-4057qib7 9722 20 SCT SCT NNP cord-005453-4057qib7 9722 21 with with IN cord-005453-4057qib7 9722 22 PTCY PTCY NNP cord-005453-4057qib7 9722 23 . . . cord-005453-4057qib7 9723 1 Methods method NNS cord-005453-4057qib7 9723 2 : : : cord-005453-4057qib7 9724 1 Our -PRON- PRP$ cord-005453-4057qib7 9724 2 study study NN cord-005453-4057qib7 9724 3 enrolled enrol VBD cord-005453-4057qib7 9724 4 42 42 CD cord-005453-4057qib7 9724 5 patients patient NNS cord-005453-4057qib7 9724 6 ( ( -LRB- cord-005453-4057qib7 9724 7 women woman NNS cord-005453-4057qib7 9724 8 / / SYM cord-005453-4057qib7 9724 9 men man NNS cord-005453-4057qib7 9724 10 , , , cord-005453-4057qib7 9724 11 19/23 19/23 CD cord-005453-4057qib7 9724 12 ) ) -RRB- cord-005453-4057qib7 9724 13 , , , cord-005453-4057qib7 9724 14 who who WP cord-005453-4057qib7 9724 15 underwent undergo VBD cord-005453-4057qib7 9724 16 T T NNP cord-005453-4057qib7 9724 17 cell cell NN cord-005453-4057qib7 9724 18 replete replete JJ cord-005453-4057qib7 9724 19 haplo haplo NNP cord-005453-4057qib7 9724 20 - - HYPH cord-005453-4057qib7 9724 21 SCT SCT NNP cord-005453-4057qib7 9724 22 from from IN cord-005453-4057qib7 9724 23 12/ 12/ CD cord-005453-4057qib7 9724 24 2013 2013 CD cord-005453-4057qib7 9724 25 to to IN cord-005453-4057qib7 9724 26 10/2018 10/2018 CD cord-005453-4057qib7 9724 27 and and CC cord-005453-4057qib7 9724 28 achieved achieve VBN cord-005453-4057qib7 9724 29 hematopoietic hematopoietic JJ cord-005453-4057qib7 9724 30 engraftment engraftment NN cord-005453-4057qib7 9724 31 . . . cord-005453-4057qib7 9725 1 Median median JJ cord-005453-4057qib7 9725 2 age age NN cord-005453-4057qib7 9725 3 at at IN cord-005453-4057qib7 9725 4 transplant transplant NN cord-005453-4057qib7 9725 5 was be VBD cord-005453-4057qib7 9725 6 53.5 53.5 CD cord-005453-4057qib7 9725 7 years year NNS cord-005453-4057qib7 9726 1 ( ( -LRB- cord-005453-4057qib7 9726 2 range range NN cord-005453-4057qib7 9726 3 , , , cord-005453-4057qib7 9726 4 19 19 CD cord-005453-4057qib7 9726 5 - - SYM cord-005453-4057qib7 9726 6 70 70 CD cord-005453-4057qib7 9726 7 ) ) -RRB- cord-005453-4057qib7 9726 8 . . . cord-005453-4057qib7 9727 1 The the DT cord-005453-4057qib7 9727 2 underlying underlying JJ cord-005453-4057qib7 9727 3 disease disease NN cord-005453-4057qib7 9727 4 was be VBD cord-005453-4057qib7 9727 5 AML AML NNP cord-005453-4057qib7 9727 6 ( ( -LRB- cord-005453-4057qib7 9727 7 n=17 n=17 NNP cord-005453-4057qib7 9727 8 ) ) -RRB- cord-005453-4057qib7 9727 9 , , , cord-005453-4057qib7 9727 10 ALL all DT cord-005453-4057qib7 9727 11 ( ( -LRB- cord-005453-4057qib7 9727 12 n=9 n=9 NN cord-005453-4057qib7 9727 13 ) ) -RRB- cord-005453-4057qib7 9727 14 , , , cord-005453-4057qib7 9727 15 MDS MDS NNP cord-005453-4057qib7 9727 16 ( ( -LRB- cord-005453-4057qib7 9727 17 n=9 n=9 NN cord-005453-4057qib7 9727 18 ) ) -RRB- cord-005453-4057qib7 9727 19 , , , cord-005453-4057qib7 9727 20 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 9727 21 ( ( -LRB- cord-005453-4057qib7 9727 22 n=4 n=4 NNP cord-005453-4057qib7 9727 23 ) ) -RRB- cord-005453-4057qib7 9727 24 , , , cord-005453-4057qib7 9727 25 CML CML NNP cord-005453-4057qib7 9727 26 ( ( -LRB- cord-005453-4057qib7 9727 27 n=2 n=2 NNP cord-005453-4057qib7 9727 28 ) ) -RRB- cord-005453-4057qib7 9727 29 , , , cord-005453-4057qib7 9727 30 or or CC cord-005453-4057qib7 9727 31 CLL CLL NNP cord-005453-4057qib7 9727 32 ( ( -LRB- cord-005453-4057qib7 9727 33 n=1 n=1 NN cord-005453-4057qib7 9727 34 ) ) -RRB- cord-005453-4057qib7 9727 35 . . . cord-005453-4057qib7 9728 1 The the DT cord-005453-4057qib7 9728 2 conditioning conditioning NN cord-005453-4057qib7 9728 3 regimen regimen NN cord-005453-4057qib7 9728 4 was be VBD cord-005453-4057qib7 9728 5 myeloablative myeloablative NNP cord-005453-4057qib7 9728 6 ( ( -LRB- cord-005453-4057qib7 9728 7 n=31 n=31 NNP cord-005453-4057qib7 9728 8 ) ) -RRB- cord-005453-4057qib7 9728 9 , , , cord-005453-4057qib7 9728 10 reduced reduce VBN cord-005453-4057qib7 9728 11 - - HYPH cord-005453-4057qib7 9728 12 intensity intensity NN cord-005453-4057qib7 9728 13 ( ( -LRB- cord-005453-4057qib7 9728 14 n=10 n=10 NNP cord-005453-4057qib7 9728 15 ) ) -RRB- cord-005453-4057qib7 9728 16 or or CC cord-005453-4057qib7 9728 17 non non JJ cord-005453-4057qib7 9728 18 - - JJ cord-005453-4057qib7 9728 19 myeloablative myeloablative JJ cord-005453-4057qib7 9728 20 ( ( -LRB- cord-005453-4057qib7 9728 21 n=1 n=1 JJ cord-005453-4057qib7 9728 22 ) ) -RRB- cord-005453-4057qib7 9728 23 . . . cord-005453-4057qib7 9729 1 Peripheral peripheral JJ cord-005453-4057qib7 9729 2 blood blood NN cord-005453-4057qib7 9729 3 was be VBD cord-005453-4057qib7 9729 4 the the DT cord-005453-4057qib7 9729 5 graft graft NN cord-005453-4057qib7 9729 6 source source NN cord-005453-4057qib7 9729 7 in in IN cord-005453-4057qib7 9729 8 the the DT cord-005453-4057qib7 9729 9 majority majority NN cord-005453-4057qib7 9729 10 of of IN cord-005453-4057qib7 9729 11 cases case NNS cord-005453-4057qib7 9729 12 ( ( -LRB- cord-005453-4057qib7 9729 13 n=29 n=29 NNP cord-005453-4057qib7 9729 14 ) ) -RRB- cord-005453-4057qib7 9729 15 and and CC cord-005453-4057qib7 9729 16 bone bone NN cord-005453-4057qib7 9729 17 marrow marrow NN cord-005453-4057qib7 9729 18 in in IN cord-005453-4057qib7 9729 19 the the DT cord-005453-4057qib7 9729 20 remaining remain VBG cord-005453-4057qib7 9729 21 ( ( -LRB- cord-005453-4057qib7 9729 22 n=13 n=13 NNP cord-005453-4057qib7 9729 23 ) ) -RRB- cord-005453-4057qib7 9729 24 . . . cord-005453-4057qib7 9730 1 Recipient recipient NN cord-005453-4057qib7 9730 2 / / SYM cord-005453-4057qib7 9730 3 donor donor NN cord-005453-4057qib7 9730 4 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 9730 5 ( ( -LRB- cord-005453-4057qib7 9730 6 CMV CMV NNP cord-005453-4057qib7 9730 7 ) ) -RRB- cord-005453-4057qib7 9730 8 serostatus serostatus NNP cord-005453-4057qib7 9730 9 was be VBD cord-005453-4057qib7 9730 10 -/-(n=2 -/-(n=2 CD cord-005453-4057qib7 9730 11 ) ) -RRB- cord-005453-4057qib7 9730 12 , , , cord-005453-4057qib7 9730 13 -/+ -/+ NNP cord-005453-4057qib7 9731 1 ( ( -LRB- cord-005453-4057qib7 9731 2 n= n= NNP cord-005453-4057qib7 9731 3 4 4 CD cord-005453-4057qib7 9731 4 ) ) -RRB- cord-005453-4057qib7 9731 5 , , , cord-005453-4057qib7 9731 6 + + CC cord-005453-4057qib7 9731 7 /-(n=8 /-(n=8 . cord-005453-4057qib7 9731 8 ) ) -RRB- cord-005453-4057qib7 9731 9 , , , cord-005453-4057qib7 9731 10 or or CC cord-005453-4057qib7 9732 1 + + CC cord-005453-4057qib7 9732 2 /+ /+ . cord-005453-4057qib7 9733 1 ( ( -LRB- cord-005453-4057qib7 9733 2 n=28 n=28 RB cord-005453-4057qib7 9733 3 ) ) -RRB- cord-005453-4057qib7 9733 4 . . . cord-005453-4057qib7 9734 1 The the DT cord-005453-4057qib7 9734 2 combination combination NN cord-005453-4057qib7 9734 3 of of IN cord-005453-4057qib7 9734 4 tacrolimus tacrolimus NNP cord-005453-4057qib7 9734 5 and and CC cord-005453-4057qib7 9734 6 mycophenolate mycophenolate NNP cord-005453-4057qib7 9734 7 mofetil mofetil NNP cord-005453-4057qib7 9734 8 was be VBD cord-005453-4057qib7 9734 9 administered administer VBN cord-005453-4057qib7 9734 10 in in IN cord-005453-4057qib7 9734 11 addition addition NN cord-005453-4057qib7 9734 12 to to IN cord-005453-4057qib7 9734 13 PTCY PTCY NNP cord-005453-4057qib7 9734 14 for for IN cord-005453-4057qib7 9734 15 prevention prevention NN cord-005453-4057qib7 9734 16 of of IN cord-005453-4057qib7 9734 17 graftversus graftversus NNP cord-005453-4057qib7 9734 18 - - HYPH cord-005453-4057qib7 9734 19 host host NN cord-005453-4057qib7 9734 20 disease disease NN cord-005453-4057qib7 9734 21 . . . cord-005453-4057qib7 9735 1 CMV CMV NNP cord-005453-4057qib7 9735 2 , , , cord-005453-4057qib7 9735 3 Epstein Epstein NNP cord-005453-4057qib7 9735 4 - - HYPH cord-005453-4057qib7 9735 5 Barr Barr NNP cord-005453-4057qib7 9735 6 virus virus NN cord-005453-4057qib7 9735 7 ( ( -LRB- cord-005453-4057qib7 9735 8 EBV EBV NNP cord-005453-4057qib7 9735 9 ) ) -RRB- cord-005453-4057qib7 9735 10 , , , cord-005453-4057qib7 9735 11 and and CC cord-005453-4057qib7 9735 12 human human JJ cord-005453-4057qib7 9735 13 herpesvirus-6 herpesvirus-6 NNP cord-005453-4057qib7 9735 14 ( ( -LRB- cord-005453-4057qib7 9735 15 HHV-6 HHV-6 NNP cord-005453-4057qib7 9735 16 ) ) -RRB- cord-005453-4057qib7 9735 17 reactivation reactivation NN cord-005453-4057qib7 9735 18 was be VBD cord-005453-4057qib7 9735 19 monitored monitor VBN cord-005453-4057qib7 9735 20 by by IN cord-005453-4057qib7 9735 21 real real JJ cord-005453-4057qib7 9735 22 - - HYPH cord-005453-4057qib7 9735 23 time time NN cord-005453-4057qib7 9735 24 quantitative quantitative JJ cord-005453-4057qib7 9735 25 PCR PCR NNP cord-005453-4057qib7 9735 26 ( ( -LRB- cord-005453-4057qib7 9735 27 RQ RQ NNP cord-005453-4057qib7 9735 28 - - HYPH cord-005453-4057qib7 9735 29 PCR PCR NNP cord-005453-4057qib7 9735 30 ) ) -RRB- cord-005453-4057qib7 9735 31 in in IN cord-005453-4057qib7 9735 32 blood blood NN cord-005453-4057qib7 9736 1 twice twice NNP cord-005453-4057qib7 9736 2 weekly weekly JJ cord-005453-4057qib7 9736 3 post post JJ cord-005453-4057qib7 9736 4 haplo haplo NNP cord-005453-4057qib7 9736 5 - - HYPH cord-005453-4057qib7 9736 6 SCT SCT NNP cord-005453-4057qib7 9736 7 . . . cord-005453-4057qib7 9737 1 BK BK NNP cord-005453-4057qib7 9737 2 virus virus NN cord-005453-4057qib7 9737 3 ( ( -LRB- cord-005453-4057qib7 9737 4 BKV BKV NNP cord-005453-4057qib7 9737 5 ) ) -RRB- cord-005453-4057qib7 9737 6 reactivation reactivation NN cord-005453-4057qib7 9737 7 was be VBD cord-005453-4057qib7 9737 8 assessed assess VBN cord-005453-4057qib7 9737 9 by by IN cord-005453-4057qib7 9737 10 RQ RQ NNP cord-005453-4057qib7 9737 11 - - HYPH cord-005453-4057qib7 9737 12 PCR PCR NNP cord-005453-4057qib7 9737 13 in in IN cord-005453-4057qib7 9737 14 urine urine NN cord-005453-4057qib7 9737 15 and/or and/or CC cord-005453-4057qib7 9737 16 blood blood NN cord-005453-4057qib7 9737 17 specimens specimen NNS cord-005453-4057qib7 9737 18 in in IN cord-005453-4057qib7 9737 19 cases case NNS cord-005453-4057qib7 9737 20 with with IN cord-005453-4057qib7 9737 21 symptoms symptom NNS cord-005453-4057qib7 9737 22 suggestive suggestive JJ cord-005453-4057qib7 9737 23 of of IN cord-005453-4057qib7 9737 24 BKV bkv NN cord-005453-4057qib7 9737 25 - - HYPH cord-005453-4057qib7 9737 26 associated associate VBN cord-005453-4057qib7 9737 27 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 9737 28 cystitis cystitis NN cord-005453-4057qib7 9737 29 ( ( -LRB- cord-005453-4057qib7 9737 30 HC HC NNP cord-005453-4057qib7 9737 31 ) ) -RRB- cord-005453-4057qib7 9737 32 . . . cord-005453-4057qib7 9738 1 Results result NNS cord-005453-4057qib7 9738 2 : : : cord-005453-4057qib7 9739 1 With with IN cord-005453-4057qib7 9739 2 a a DT cord-005453-4057qib7 9739 3 median median JJ cord-005453-4057qib7 9739 4 follow follow NN cord-005453-4057qib7 9739 5 - - HYPH cord-005453-4057qib7 9739 6 up up NN cord-005453-4057qib7 9739 7 time time NN cord-005453-4057qib7 9739 8 of of IN cord-005453-4057qib7 9739 9 25 25 CD cord-005453-4057qib7 9739 10 months month NNS cord-005453-4057qib7 9739 11 ( ( -LRB- cord-005453-4057qib7 9739 12 range range NN cord-005453-4057qib7 9739 13 , , , cord-005453-4057qib7 9739 14 , , , cord-005453-4057qib7 9739 15 the the DT cord-005453-4057qib7 9739 16 cumulative cumulative JJ cord-005453-4057qib7 9739 17 incidences incidence NNS cord-005453-4057qib7 9739 18 ( ( -LRB- cord-005453-4057qib7 9739 19 CIN CIN NNP cord-005453-4057qib7 9739 20 ) ) -RRB- cord-005453-4057qib7 9739 21 of of IN cord-005453-4057qib7 9739 22 relapse relapse NN cord-005453-4057qib7 9739 23 and and CC cord-005453-4057qib7 9739 24 non non JJ cord-005453-4057qib7 9739 25 - - JJ cord-005453-4057qib7 9739 26 relapse relapse JJ cord-005453-4057qib7 9739 27 mortality mortality NN cord-005453-4057qib7 9739 28 ( ( -LRB- cord-005453-4057qib7 9739 29 NRM NRM NNP cord-005453-4057qib7 9739 30 ) ) -RRB- cord-005453-4057qib7 9739 31 were be VBD cord-005453-4057qib7 9739 32 15.5 15.5 CD cord-005453-4057qib7 9739 33 % % NN cord-005453-4057qib7 9739 34 ( ( -LRB- cord-005453-4057qib7 9739 35 95 95 CD cord-005453-4057qib7 9739 36 % % NN cord-005453-4057qib7 9739 37 CI CI NNP cord-005453-4057qib7 9739 38 , , , cord-005453-4057qib7 9739 39 6.2 6.2 CD cord-005453-4057qib7 9739 40 - - SYM cord-005453-4057qib7 9739 41 28.6 28.6 CD cord-005453-4057qib7 9739 42 % % NN cord-005453-4057qib7 9739 43 ) ) -RRB- cord-005453-4057qib7 9739 44 and and CC cord-005453-4057qib7 9739 45 33.3 33.3 CD cord-005453-4057qib7 9739 46 % % NN cord-005453-4057qib7 9739 47 ( ( -LRB- cord-005453-4057qib7 9739 48 95 95 CD cord-005453-4057qib7 9739 49 % % NN cord-005453-4057qib7 9739 50 CI CI NNP cord-005453-4057qib7 9739 51 , , , cord-005453-4057qib7 9739 52 18.9 18.9 CD cord-005453-4057qib7 9739 53 - - SYM cord-005453-4057qib7 9739 54 48.2 48.2 CD cord-005453-4057qib7 9739 55 % % NN cord-005453-4057qib7 9739 56 ) ) -RRB- cord-005453-4057qib7 9739 57 at at IN cord-005453-4057qib7 9739 58 2 2 CD cord-005453-4057qib7 9739 59 years year NNS cord-005453-4057qib7 9739 60 , , , cord-005453-4057qib7 9739 61 respectively respectively RB cord-005453-4057qib7 9739 62 . . . cord-005453-4057qib7 9740 1 Median median JJ cord-005453-4057qib7 9740 2 disease disease NN cord-005453-4057qib7 9740 3 - - HYPH cord-005453-4057qib7 9740 4 free free JJ cord-005453-4057qib7 9740 5 ( ( -LRB- cord-005453-4057qib7 9740 6 DFS DFS NNP cord-005453-4057qib7 9740 7 ) ) -RRB- cord-005453-4057qib7 9740 8 and and CC cord-005453-4057qib7 9740 9 overall overall JJ cord-005453-4057qib7 9740 10 survival survival NN cord-005453-4057qib7 9740 11 ( ( -LRB- cord-005453-4057qib7 9740 12 OS OS NNP cord-005453-4057qib7 9740 13 ) ) -RRB- cord-005453-4057qib7 9740 14 were be VBD cord-005453-4057qib7 9740 15 53.3 53.3 CD cord-005453-4057qib7 9740 16 % % NN cord-005453-4057qib7 9740 17 ( ( -LRB- cord-005453-4057qib7 9740 18 95 95 CD cord-005453-4057qib7 9740 19 % % NN cord-005453-4057qib7 9740 20 CI CI NNP cord-005453-4057qib7 9740 21 , , , cord-005453-4057qib7 9740 22 39.5 39.5 CD cord-005453-4057qib7 9740 23 - - HYPH cord-005453-4057qib7 9740 24 71.9 71.9 CD cord-005453-4057qib7 9740 25 % % NN cord-005453-4057qib7 9740 26 ) ) -RRB- cord-005453-4057qib7 9740 27 and and CC cord-005453-4057qib7 9740 28 58.4 58.4 CD cord-005453-4057qib7 9740 29 % % NN cord-005453-4057qib7 9740 30 ( ( -LRB- cord-005453-4057qib7 9740 31 95 95 CD cord-005453-4057qib7 9740 32 % % NN cord-005453-4057qib7 9740 33 CI CI NNP cord-005453-4057qib7 9740 34 , , , cord-005453-4057qib7 9740 35 44.6 44.6 CD cord-005453-4057qib7 9740 36 - - SYM cord-005453-4057qib7 9740 37 76.5 76.5 CD cord-005453-4057qib7 9740 38 % % NN cord-005453-4057qib7 9740 39 ) ) -RRB- cord-005453-4057qib7 9740 40 at at IN cord-005453-4057qib7 9740 41 2 2 CD cord-005453-4057qib7 9740 42 years year NNS cord-005453-4057qib7 9740 43 , , , cord-005453-4057qib7 9740 44 respectively respectively RB cord-005453-4057qib7 9740 45 . . . cord-005453-4057qib7 9741 1 The the DT cord-005453-4057qib7 9741 2 CIN CIN NNP cord-005453-4057qib7 9741 3 of of IN cord-005453-4057qib7 9741 4 CMV CMV NNP cord-005453-4057qib7 9741 5 reactivation reactivation NN cord-005453-4057qib7 9741 6 / / SYM cord-005453-4057qib7 9741 7 infection infection NN cord-005453-4057qib7 9741 8 ( ( -LRB- cord-005453-4057qib7 9741 9 > > NFP cord-005453-4057qib7 9741 10 100 100 CD cord-005453-4057qib7 9741 11 copies copy NNS cord-005453-4057qib7 9741 12 / / SYM cord-005453-4057qib7 9741 13 ml ml NN cord-005453-4057qib7 9741 14 ) ) -RRB- cord-005453-4057qib7 9741 15 reached reach VBD cord-005453-4057qib7 9741 16 75.7 75.7 CD cord-005453-4057qib7 9741 17 % % NN cord-005453-4057qib7 9741 18 ( ( -LRB- cord-005453-4057qib7 9741 19 95 95 CD cord-005453-4057qib7 9741 20 % % NN cord-005453-4057qib7 9741 21 CI CI NNP cord-005453-4057qib7 9741 22 , , , cord-005453-4057qib7 9741 23 58.8 58.8 CD cord-005453-4057qib7 9741 24 - - HYPH cord-005453-4057qib7 9741 25 86.4 86.4 CD cord-005453-4057qib7 9741 26 % % NN cord-005453-4057qib7 9741 27 ) ) -RRB- cord-005453-4057qib7 9741 28 at at IN cord-005453-4057qib7 9741 29 3 3 CD cord-005453-4057qib7 9741 30 months month NNS cord-005453-4057qib7 9741 31 . . . cord-005453-4057qib7 9742 1 CMV CMV NNP cord-005453-4057qib7 9742 2 infection infection NN cord-005453-4057qib7 9742 3 developed develop VBD cord-005453-4057qib7 9742 4 in in IN cord-005453-4057qib7 9742 5 30 30 CD cord-005453-4057qib7 9742 6 out out IN cord-005453-4057qib7 9742 7 of of IN cord-005453-4057qib7 9742 8 40 40 CD cord-005453-4057qib7 9742 9 patients patient NNS cord-005453-4057qib7 9742 10 who who WP cord-005453-4057qib7 9742 11 were be VBD cord-005453-4057qib7 9742 12 at at IN cord-005453-4057qib7 9742 13 risk risk NN cord-005453-4057qib7 9742 14 , , , cord-005453-4057qib7 9742 15 whereas whereas IN cord-005453-4057qib7 9742 16 recurrent recurrent JJ cord-005453-4057qib7 9742 17 CMV CMV NNP cord-005453-4057qib7 9742 18 reactivation reactivation NN cord-005453-4057qib7 9742 19 was be VBD cord-005453-4057qib7 9742 20 observed observe VBN cord-005453-4057qib7 9742 21 in in IN cord-005453-4057qib7 9742 22 15 15 CD cord-005453-4057qib7 9742 23 patients patient NNS cord-005453-4057qib7 9742 24 with with IN cord-005453-4057qib7 9742 25 a a DT cord-005453-4057qib7 9742 26 median median JJ cord-005453-4057qib7 9742 27 number number NN cord-005453-4057qib7 9742 28 of of IN cord-005453-4057qib7 9742 29 2 2 CD cord-005453-4057qib7 9742 30 episodes episode NNS cord-005453-4057qib7 9742 31 ( ( -LRB- cord-005453-4057qib7 9742 32 range range NN cord-005453-4057qib7 9742 33 , , , cord-005453-4057qib7 9742 34 2 2 CD cord-005453-4057qib7 9742 35 - - SYM cord-005453-4057qib7 9742 36 6 6 CD cord-005453-4057qib7 9742 37 ) ) -RRB- cord-005453-4057qib7 9742 38 per per IN cord-005453-4057qib7 9742 39 patient patient NN cord-005453-4057qib7 9742 40 . . . cord-005453-4057qib7 9743 1 The the DT cord-005453-4057qib7 9743 2 median median JJ cord-005453-4057qib7 9743 3 total total JJ cord-005453-4057qib7 9743 4 duration duration NN cord-005453-4057qib7 9743 5 of of IN cord-005453-4057qib7 9743 6 antiviral antiviral JJ cord-005453-4057qib7 9743 7 therapy therapy NN cord-005453-4057qib7 9743 8 for for IN cord-005453-4057qib7 9743 9 CMV CMV NNP cord-005453-4057qib7 9743 10 infection infection NN cord-005453-4057qib7 9743 11 was be VBD cord-005453-4057qib7 9743 12 27 27 CD cord-005453-4057qib7 9743 13 days day NNS cord-005453-4057qib7 9743 14 ( ( -LRB- cord-005453-4057qib7 9743 15 range range NN cord-005453-4057qib7 9743 16 , , , cord-005453-4057qib7 9743 17 14 14 CD cord-005453-4057qib7 9743 18 - - SYM cord-005453-4057qib7 9743 19 199 199 CD cord-005453-4057qib7 9743 20 ) ) -RRB- cord-005453-4057qib7 9743 21 . . . cord-005453-4057qib7 9744 1 CMV CMV NNP cord-005453-4057qib7 9744 2 disease disease NN cord-005453-4057qib7 9744 3 ( ( -LRB- cord-005453-4057qib7 9744 4 pneumonia pneumonia NN cord-005453-4057qib7 9744 5 ) ) -RRB- cord-005453-4057qib7 9744 6 was be VBD cord-005453-4057qib7 9744 7 documented document VBN cord-005453-4057qib7 9744 8 in in IN cord-005453-4057qib7 9744 9 2 2 CD cord-005453-4057qib7 9744 10 patients patient NNS cord-005453-4057qib7 9744 11 . . . cord-005453-4057qib7 9745 1 The the DT cord-005453-4057qib7 9745 2 CIN CIN NNP cord-005453-4057qib7 9745 3 of of IN cord-005453-4057qib7 9745 4 EBV EBV NNP cord-005453-4057qib7 9745 5 reactivation reactivation NN cord-005453-4057qib7 9745 6 ( ( -LRB- cord-005453-4057qib7 9745 7 > > NFP cord-005453-4057qib7 9745 8 1,000 1,000 CD cord-005453-4057qib7 9745 9 copies copy NNS cord-005453-4057qib7 9745 10 / / SYM cord-005453-4057qib7 9745 11 ml ml NN cord-005453-4057qib7 9745 12 ) ) -RRB- cord-005453-4057qib7 9745 13 was be VBD cord-005453-4057qib7 9745 14 50.9 50.9 CD cord-005453-4057qib7 9745 15 % % NN cord-005453-4057qib7 9745 16 ( ( -LRB- cord-005453-4057qib7 9745 17 95 95 CD cord-005453-4057qib7 9745 18 % % NN cord-005453-4057qib7 9745 19 CI CI NNP cord-005453-4057qib7 9745 20 , , , cord-005453-4057qib7 9745 21 34.2 34.2 CD cord-005453-4057qib7 9745 22 - - HYPH cord-005453-4057qib7 9745 23 65.3 65.3 CD cord-005453-4057qib7 9745 24 % % NN cord-005453-4057qib7 9745 25 ) ) -RRB- cord-005453-4057qib7 9745 26 at at IN cord-005453-4057qib7 9745 27 12 12 CD cord-005453-4057qib7 9745 28 months month NNS cord-005453-4057qib7 9745 29 . . . cord-005453-4057qib7 9746 1 No no DT cord-005453-4057qib7 9746 2 case case NN cord-005453-4057qib7 9746 3 of of IN cord-005453-4057qib7 9746 4 EBV EBV NNP cord-005453-4057qib7 9746 5 - - HYPH cord-005453-4057qib7 9746 6 related relate VBN cord-005453-4057qib7 9746 7 post post JJ cord-005453-4057qib7 9746 8 - - JJ cord-005453-4057qib7 9746 9 transplant transplant JJ cord-005453-4057qib7 9746 10 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 9746 11 disorder disorder NN cord-005453-4057qib7 9746 12 was be VBD cord-005453-4057qib7 9746 13 observed observe VBN cord-005453-4057qib7 9746 14 , , , cord-005453-4057qib7 9746 15 however however RB cord-005453-4057qib7 9746 16 preemptive preemptive JJ cord-005453-4057qib7 9746 17 therapy therapy NN cord-005453-4057qib7 9746 18 with with IN cord-005453-4057qib7 9746 19 rituximab rituximab NNP cord-005453-4057qib7 9746 20 was be VBD cord-005453-4057qib7 9746 21 required require VBN cord-005453-4057qib7 9746 22 in in IN cord-005453-4057qib7 9746 23 2 2 CD cord-005453-4057qib7 9746 24 patients patient NNS cord-005453-4057qib7 9746 25 with with IN cord-005453-4057qib7 9746 26 rapidly rapidly RB cord-005453-4057qib7 9746 27 increasing increase VBG cord-005453-4057qib7 9746 28 EBV EBV NNP cord-005453-4057qib7 9746 29 viral viral JJ cord-005453-4057qib7 9746 30 load load NN cord-005453-4057qib7 9746 31 . . . cord-005453-4057qib7 9747 1 HHV-6 HHV-6 NNP cord-005453-4057qib7 9747 2 reactivation reactivation NN cord-005453-4057qib7 9747 3 ( ( -LRB- cord-005453-4057qib7 9747 4 > > NFP cord-005453-4057qib7 9747 5 1,000 1,000 CD cord-005453-4057qib7 9747 6 copies copy NNS cord-005453-4057qib7 9747 7 / / SYM cord-005453-4057qib7 9747 8 ml ml NN cord-005453-4057qib7 9747 9 ) ) -RRB- cord-005453-4057qib7 9747 10 was be VBD cord-005453-4057qib7 9747 11 observed observe VBN cord-005453-4057qib7 9747 12 in in IN cord-005453-4057qib7 9747 13 5 5 CD cord-005453-4057qib7 9747 14 patients patient NNS cord-005453-4057qib7 9747 15 ( ( -LRB- cord-005453-4057qib7 9747 16 CIN CIN NNP cord-005453-4057qib7 9747 17 , , , cord-005453-4057qib7 9747 18 12.3 12.3 CD cord-005453-4057qib7 9747 19 % % NN cord-005453-4057qib7 9747 20 at at IN cord-005453-4057qib7 9747 21 6 6 CD cord-005453-4057qib7 9747 22 months month NNS cord-005453-4057qib7 9747 23 ; ; : cord-005453-4057qib7 9747 24 95 95 CD cord-005453-4057qib7 9747 25 % % NN cord-005453-4057qib7 9747 26 CI CI NNP cord-005453-4057qib7 9747 27 , , , cord-005453-4057qib7 9747 28 4.4 4.4 CD cord-005453-4057qib7 9747 29 - - SYM cord-005453-4057qib7 9747 30 24.5 24.5 CD cord-005453-4057qib7 9747 31 % % NN cord-005453-4057qib7 9747 32 ) ) -RRB- cord-005453-4057qib7 9747 33 , , , cord-005453-4057qib7 9747 34 with with IN cord-005453-4057qib7 9747 35 none none NN cord-005453-4057qib7 9747 36 of of IN cord-005453-4057qib7 9747 37 them -PRON- PRP cord-005453-4057qib7 9747 38 requiring require VBG cord-005453-4057qib7 9747 39 specific specific JJ cord-005453-4057qib7 9747 40 therapy therapy NN cord-005453-4057qib7 9747 41 . . . cord-005453-4057qib7 9748 1 BKV BKV NNP cord-005453-4057qib7 9748 2 - - HYPH cord-005453-4057qib7 9748 3 related relate VBN cord-005453-4057qib7 9748 4 HC HC NNP cord-005453-4057qib7 9748 5 occurred occur VBD cord-005453-4057qib7 9748 6 at at IN cord-005453-4057qib7 9748 7 a a DT cord-005453-4057qib7 9748 8 CIN CIN NNP cord-005453-4057qib7 9748 9 of of IN cord-005453-4057qib7 9748 10 23.9 23.9 CD cord-005453-4057qib7 9748 11 % % NN cord-005453-4057qib7 9748 12 ( ( -LRB- cord-005453-4057qib7 9748 13 95 95 CD cord-005453-4057qib7 9748 14 % % NN cord-005453-4057qib7 9748 15 CI CI NNP cord-005453-4057qib7 9748 16 , , , cord-005453-4057qib7 9748 17 12.3 12.3 CD cord-005453-4057qib7 9748 18 - - HYPH cord-005453-4057qib7 9748 19 37.7 37.7 CD cord-005453-4057qib7 9748 20 % % NN cord-005453-4057qib7 9748 21 ) ) -RRB- cord-005453-4057qib7 9748 22 at at IN cord-005453-4057qib7 9748 23 6 6 CD cord-005453-4057qib7 9748 24 months month NNS cord-005453-4057qib7 9748 25 . . . cord-005453-4057qib7 9749 1 Cystoscopy Cystoscopy NNP cord-005453-4057qib7 9749 2 for for IN cord-005453-4057qib7 9749 3 bladder bladder NN cord-005453-4057qib7 9749 4 hemostasis hemostasis NN cord-005453-4057qib7 9749 5 was be VBD cord-005453-4057qib7 9749 6 required require VBN cord-005453-4057qib7 9749 7 in in IN cord-005453-4057qib7 9749 8 4/11 4/11 CD cord-005453-4057qib7 9749 9 and and CC cord-005453-4057qib7 9749 10 nephrostomy nephrostomy VB cord-005453-4057qib7 9749 11 in in IN cord-005453-4057qib7 9749 12 1/11 1/11 CD cord-005453-4057qib7 9749 13 patients patient NNS cord-005453-4057qib7 9749 14 with with IN cord-005453-4057qib7 9749 15 HC HC NNP cord-005453-4057qib7 9749 16 . . . cord-005453-4057qib7 9750 1 Conclusions conclusion NNS cord-005453-4057qib7 9750 2 : : : cord-005453-4057qib7 9751 1 Despite despite IN cord-005453-4057qib7 9751 2 preservation preservation NN cord-005453-4057qib7 9751 3 of of IN cord-005453-4057qib7 9751 4 non non JJ cord-005453-4057qib7 9751 5 - - JJ cord-005453-4057qib7 9751 6 alloreactive alloreactive JJ cord-005453-4057qib7 9751 7 memory memory NN cord-005453-4057qib7 9751 8 T T NNP cord-005453-4057qib7 9751 9 cells cell NNS cord-005453-4057qib7 9751 10 , , , cord-005453-4057qib7 9751 11 haplo haplo NN cord-005453-4057qib7 9751 12 - - HYPH cord-005453-4057qib7 9751 13 SCT SCT NNP cord-005453-4057qib7 9751 14 with with IN cord-005453-4057qib7 9751 15 PTCY PTCY NNP cord-005453-4057qib7 9751 16 is be VBZ cord-005453-4057qib7 9751 17 associated associate VBN cord-005453-4057qib7 9751 18 with with IN cord-005453-4057qib7 9751 19 substantial substantial JJ cord-005453-4057qib7 9751 20 rates rate NNS cord-005453-4057qib7 9751 21 of of IN cord-005453-4057qib7 9751 22 viral viral JJ cord-005453-4057qib7 9751 23 reactivation reactivation NN cord-005453-4057qib7 9751 24 ( ( -LRB- cord-005453-4057qib7 9751 25 especially especially RB cord-005453-4057qib7 9751 26 CMV CMV NNP cord-005453-4057qib7 9751 27 and and CC cord-005453-4057qib7 9751 28 BKV BKV NNP cord-005453-4057qib7 9751 29 ) ) -RRB- cord-005453-4057qib7 9751 30 resulting result VBG cord-005453-4057qib7 9751 31 in in IN cord-005453-4057qib7 9751 32 the the DT cord-005453-4057qib7 9751 33 need need NN cord-005453-4057qib7 9751 34 for for IN cord-005453-4057qib7 9751 35 prolonged prolong VBN cord-005453-4057qib7 9751 36 antiviral antiviral JJ cord-005453-4057qib7 9751 37 therapy therapy NN cord-005453-4057qib7 9751 38 and and CC cord-005453-4057qib7 9751 39 considerable considerable JJ cord-005453-4057qib7 9751 40 morbidity morbidity NN cord-005453-4057qib7 9751 41 as as RB cord-005453-4057qib7 9751 42 well well RB cord-005453-4057qib7 9751 43 . . . cord-005453-4057qib7 9752 1 Therefore therefore RB cord-005453-4057qib7 9752 2 , , , cord-005453-4057qib7 9752 3 strategies strategy NNS cord-005453-4057qib7 9752 4 to to TO cord-005453-4057qib7 9752 5 prevent prevent VB cord-005453-4057qib7 9752 6 viral viral JJ cord-005453-4057qib7 9752 7 reactivation reactivation NN cord-005453-4057qib7 9752 8 and and CC cord-005453-4057qib7 9752 9 disease disease NN cord-005453-4057qib7 9752 10 are be VBP cord-005453-4057qib7 9752 11 still still RB cord-005453-4057qib7 9752 12 warranted warrant VBN cord-005453-4057qib7 9752 13 in in IN cord-005453-4057qib7 9752 14 haploidentical haploidentical JJ cord-005453-4057qib7 9752 15 stem stem NN cord-005453-4057qib7 9752 16 cell cell NN cord-005453-4057qib7 9752 17 transplantation transplantation NN cord-005453-4057qib7 9752 18 . . . cord-005453-4057qib7 9753 1 Disclosure disclosure NN cord-005453-4057qib7 9753 2 : : : cord-005453-4057qib7 9753 3 Nothing nothing NN cord-005453-4057qib7 9753 4 to to TO cord-005453-4057qib7 9753 5 declare declare VB cord-005453-4057qib7 9753 6 . . . cord-005453-4057qib7 9754 1 Background background NN cord-005453-4057qib7 9754 2 : : : cord-005453-4057qib7 9755 1 Adenovirus(AdV adenovirus(adv LS cord-005453-4057qib7 9755 2 ) ) -RRB- cord-005453-4057qib7 9755 3 infections infection NNS cord-005453-4057qib7 9755 4 are be VBP cord-005453-4057qib7 9755 5 a a DT cord-005453-4057qib7 9755 6 wellrecognised wellrecognised JJ cord-005453-4057qib7 9755 7 cause cause NN cord-005453-4057qib7 9755 8 of of IN cord-005453-4057qib7 9755 9 morbidity morbidity NN cord-005453-4057qib7 9755 10 and and CC cord-005453-4057qib7 9755 11 mortality mortality NN cord-005453-4057qib7 9755 12 in in IN cord-005453-4057qib7 9755 13 children child NNS cord-005453-4057qib7 9755 14 and and CC cord-005453-4057qib7 9755 15 adults adult NNS cord-005453-4057qib7 9755 16 receiving receive VBG cord-005453-4057qib7 9755 17 an an DT cord-005453-4057qib7 9755 18 allogenic allogenic JJ cord-005453-4057qib7 9755 19 stem stem NN cord-005453-4057qib7 9755 20 cell cell NN cord-005453-4057qib7 9756 1 transplant(HSCT).The transplant(hsct).the CD cord-005453-4057qib7 9756 2 reported report VBN cord-005453-4057qib7 9756 3 incidence incidence NN cord-005453-4057qib7 9756 4 of of IN cord-005453-4057qib7 9756 5 AdV adv NN cord-005453-4057qib7 9756 6 infection infection NN cord-005453-4057qib7 9756 7 is be VBZ cord-005453-4057qib7 9756 8 higher(6%-42 higher(6%-42 NNP cord-005453-4057qib7 9756 9 % % NN cord-005453-4057qib7 9756 10 ) ) -RRB- cord-005453-4057qib7 9756 11 in in IN cord-005453-4057qib7 9756 12 paediatric paediatric JJ cord-005453-4057qib7 9756 13 HSCT HSCT NNP cord-005453-4057qib7 9756 14 than than IN cord-005453-4057qib7 9756 15 in in IN cord-005453-4057qib7 9756 16 adults(3 adults(3 CD cord-005453-4057qib7 9756 17 - - HYPH cord-005453-4057qib7 9756 18 27%),but 27%),but CD cord-005453-4057qib7 9757 1 we -PRON- PRP cord-005453-4057qib7 9757 2 currently currently RB cord-005453-4057qib7 9757 3 lack lack VBP cord-005453-4057qib7 9757 4 accurate accurate JJ cord-005453-4057qib7 9757 5 data datum NNS cord-005453-4057qib7 9757 6 of of IN cord-005453-4057qib7 9757 7 AdV adv NN cord-005453-4057qib7 9757 8 infection infection NN cord-005453-4057qib7 9757 9 burden burden NN cord-005453-4057qib7 9757 10 among among IN cord-005453-4057qib7 9757 11 adults adult NNS cord-005453-4057qib7 9757 12 . . . cord-005453-4057qib7 9758 1 Cidofovir Cidofovir NNP cord-005453-4057qib7 9758 2 has have VBZ cord-005453-4057qib7 9758 3 been be VBN cord-005453-4057qib7 9758 4 extensively extensively RB cord-005453-4057qib7 9758 5 used use VBN cord-005453-4057qib7 9758 6 as as IN cord-005453-4057qib7 9758 7 a a DT cord-005453-4057qib7 9758 8 pre pre JJ cord-005453-4057qib7 9758 9 - - JJ cord-005453-4057qib7 9758 10 emptive emptive JJ cord-005453-4057qib7 9758 11 anti anti JJ cord-005453-4057qib7 9758 12 - - JJ cord-005453-4057qib7 9758 13 adenoviral adenoviral JJ cord-005453-4057qib7 9758 14 therapy therapy NN cord-005453-4057qib7 9758 15 and and CC cord-005453-4057qib7 9758 16 is be VBZ cord-005453-4057qib7 9758 17 current current JJ cord-005453-4057qib7 9758 18 standard standard NN cord-005453-4057qib7 9758 19 of of IN cord-005453-4057qib7 9758 20 care care NN cord-005453-4057qib7 9758 21 . . . cord-005453-4057qib7 9759 1 We -PRON- PRP cord-005453-4057qib7 9759 2 present present VBP cord-005453-4057qib7 9759 3 our -PRON- PRP$ cord-005453-4057qib7 9759 4 single single JJ cord-005453-4057qib7 9759 5 centre centre NN cord-005453-4057qib7 9759 6 experience experience NN cord-005453-4057qib7 9759 7 of of IN cord-005453-4057qib7 9759 8 AdV adv NN cord-005453-4057qib7 9759 9 incidence incidence NN cord-005453-4057qib7 9759 10 and and CC cord-005453-4057qib7 9759 11 outcomes outcome NNS cord-005453-4057qib7 9759 12 with with IN cord-005453-4057qib7 9759 13 pre pre JJ cord-005453-4057qib7 9759 14 - - JJ cord-005453-4057qib7 9759 15 emptive emptive JJ cord-005453-4057qib7 9759 16 approach approach NN cord-005453-4057qib7 9759 17 in in IN cord-005453-4057qib7 9759 18 adult adult NN cord-005453-4057qib7 9759 19 patients patient NNS cord-005453-4057qib7 9759 20 receiving receive VBG cord-005453-4057qib7 9759 21 T t NN cord-005453-4057qib7 9759 22 - - HYPH cord-005453-4057qib7 9759 23 cell cell NN cord-005453-4057qib7 9759 24 depleted(TCD depleted(tcd NN cord-005453-4057qib7 9759 25 ) ) -RRB- cord-005453-4057qib7 9759 26 HSCTs hsct NNS cord-005453-4057qib7 9759 27 for for IN cord-005453-4057qib7 9759 28 myeloid myeloid JJ cord-005453-4057qib7 9759 29 disorders disorder NNS cord-005453-4057qib7 9759 30 . . . cord-005453-4057qib7 9760 1 Methods method NNS cord-005453-4057qib7 9760 2 : : : cord-005453-4057qib7 9760 3 This this DT cord-005453-4057qib7 9760 4 is be VBZ cord-005453-4057qib7 9760 5 a a DT cord-005453-4057qib7 9760 6 single single JJ cord-005453-4057qib7 9760 7 - - HYPH cord-005453-4057qib7 9760 8 centre centre NN cord-005453-4057qib7 9760 9 retrospective retrospective JJ cord-005453-4057qib7 9760 10 analysis analysis NN cord-005453-4057qib7 9760 11 of of IN cord-005453-4057qib7 9760 12 332 332 CD cord-005453-4057qib7 9760 13 consecutive consecutive JJ cord-005453-4057qib7 9760 14 HSCT HSCT NNP cord-005453-4057qib7 9760 15 patients patient NNS cord-005453-4057qib7 9760 16 for for IN cord-005453-4057qib7 9760 17 myeloid myeloid JJ cord-005453-4057qib7 9760 18 disorders disorder NNS cord-005453-4057qib7 9760 19 including include VBG cord-005453-4057qib7 9760 20 AML AML NNP cord-005453-4057qib7 9760 21 , , , cord-005453-4057qib7 9760 22 MDS MDS NNP cord-005453-4057qib7 9760 23 , , , cord-005453-4057qib7 9760 24 MPN MPN NNP cord-005453-4057qib7 9760 25 & & CC cord-005453-4057qib7 9760 26 Aplastic Aplastic NNP cord-005453-4057qib7 9760 27 Anaemia Anaemia NNP cord-005453-4057qib7 9760 28 between between IN cord-005453-4057qib7 9760 29 January January NNP cord-005453-4057qib7 9760 30 2012-June 2012-june CD cord-005453-4057qib7 9760 31 2016 2016 CD cord-005453-4057qib7 9760 32 using use VBG cord-005453-4057qib7 9760 33 ATG ATG NNP cord-005453-4057qib7 9760 34 or or CC cord-005453-4057qib7 9760 35 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 9760 36 based base VBD cord-005453-4057qib7 9760 37 TCD.AdV tcd.adv NN cord-005453-4057qib7 9760 38 screening screening NN cord-005453-4057qib7 9760 39 was be VBD cord-005453-4057qib7 9760 40 performed perform VBN cord-005453-4057qib7 9760 41 in in IN cord-005453-4057qib7 9760 42 all all DT cord-005453-4057qib7 9760 43 patients patient NNS cord-005453-4057qib7 9760 44 with with IN cord-005453-4057qib7 9760 45 standardised standardised JJ cord-005453-4057qib7 9760 46 real real JJ cord-005453-4057qib7 9760 47 time time NN cord-005453-4057qib7 9760 48 quantitative quantitative JJ cord-005453-4057qib7 9760 49 PCR PCR NNP cord-005453-4057qib7 9760 50 on on IN cord-005453-4057qib7 9760 51 weekly weekly JJ cord-005453-4057qib7 9760 52 basis basis NN cord-005453-4057qib7 9760 53 during during IN cord-005453-4057qib7 9760 54 standard standard JJ cord-005453-4057qib7 9760 55 risk risk NN cord-005453-4057qib7 9760 56 period period NN cord-005453-4057qib7 9760 57 . . . cord-005453-4057qib7 9761 1 Figure figure NN cord-005453-4057qib7 9761 2 1A 1a NN cord-005453-4057qib7 9761 3 -1B -1b NN cord-005453-4057qib7 9761 4 ] ] -RRB- cord-005453-4057qib7 9762 1 Results result NNS cord-005453-4057qib7 9762 2 : : : cord-005453-4057qib7 9762 3 Baseline baseline JJ cord-005453-4057qib7 9762 4 characteristics characteristic NNS cord-005453-4057qib7 9762 5 ( ( -LRB- cord-005453-4057qib7 9762 6 Table1 Table1 NNP cord-005453-4057qib7 9762 7 ) ) -RRB- cord-005453-4057qib7 9762 8 of of IN cord-005453-4057qib7 9762 9 patients patient NNS cord-005453-4057qib7 9762 10 were be VBD cord-005453-4057qib7 9762 11 similar similar JJ cord-005453-4057qib7 9762 12 across across IN cord-005453-4057qib7 9762 13 both both DT cord-005453-4057qib7 9762 14 cohorts cohort NNS cord-005453-4057qib7 9762 15 with with IN cord-005453-4057qib7 9762 16 or or CC cord-005453-4057qib7 9762 17 without without IN cord-005453-4057qib7 9762 18 AdV adv NN cord-005453-4057qib7 9762 19 infection infection NN cord-005453-4057qib7 9762 20 . . . cord-005453-4057qib7 9763 1 Overall overall JJ cord-005453-4057qib7 9763 2 12.6%(n-42/332 12.6%(n-42/332 CD cord-005453-4057qib7 9763 3 ) ) -RRB- cord-005453-4057qib7 9763 4 patients patient NNS cord-005453-4057qib7 9763 5 were be VBD cord-005453-4057qib7 9763 6 positive positive JJ cord-005453-4057qib7 9763 7 for for IN cord-005453-4057qib7 9763 8 AdV adv NN cord-005453-4057qib7 9763 9 DNA DNA NNP cord-005453-4057qib7 9763 10 on on RP cord-005453-4057qib7 9763 11 atleast atleast IN cord-005453-4057qib7 9763 12 one one CD cord-005453-4057qib7 9763 13 of of IN cord-005453-4057qib7 9763 14 the the DT cord-005453-4057qib7 9763 15 sanctuary sanctuary NN cord-005453-4057qib7 9763 16 sites(upper sites(upper CC cord-005453-4057qib7 9763 17 respiratory respiratory JJ cord-005453-4057qib7 9763 18 airway airway NN cord-005453-4057qib7 9763 19 , , , cord-005453-4057qib7 9763 20 blood blood NN cord-005453-4057qib7 9763 21 , , , cord-005453-4057qib7 9763 22 faeces faece NNS cord-005453-4057qib7 9763 23 , , , cord-005453-4057qib7 9763 24 urine urine NN cord-005453-4057qib7 9763 25 ) ) -RRB- cord-005453-4057qib7 9763 26 and and CC cord-005453-4057qib7 9763 27 45%(n-19/42 45%(n-19/42 CD cord-005453-4057qib7 9763 28 ) ) -RRB- cord-005453-4057qib7 9763 29 of of IN cord-005453-4057qib7 9763 30 these these DT cord-005453-4057qib7 9763 31 experienced experience VBN cord-005453-4057qib7 9763 32 disseminated disseminate VBN cord-005453-4057qib7 9763 33 infection(defined infection(define VBN cord-005453-4057qib7 9763 34 by by IN cord-005453-4057qib7 9763 35 AdV adv NN cord-005453-4057qib7 9763 36 in in IN cord-005453-4057qib7 9763 37 ≥2 ≥2 NNP cord-005453-4057qib7 9763 38 sanctuary sanctuary NN cord-005453-4057qib7 9763 39 sites site NNS cord-005453-4057qib7 9763 40 or or CC cord-005453-4057qib7 9763 41 rising rise VBG cord-005453-4057qib7 9763 42 AdV adv NN cord-005453-4057qib7 9763 43 DNA dna NN cord-005453-4057qib7 9763 44 copies copy NNS cord-005453-4057qib7 9763 45 in in IN cord-005453-4057qib7 9763 46 blood blood NN cord-005453-4057qib7 9763 47 ) ) -RRB- cord-005453-4057qib7 9763 48 , , , cord-005453-4057qib7 9763 49 while while IN cord-005453-4057qib7 9763 50 2 2 CD cord-005453-4057qib7 9763 51 developed develop VBD cord-005453-4057qib7 9763 52 typical typical JJ cord-005453-4057qib7 9763 53 adenoviral adenoviral JJ cord-005453-4057qib7 9763 54 disease disease NN cord-005453-4057qib7 9763 55 ( ( -LRB- cord-005453-4057qib7 9763 56 pulmonary pulmonary NNP cord-005453-4057qib7 9763 57 ) ) -RRB- cord-005453-4057qib7 9763 58 . . . cord-005453-4057qib7 9764 1 Among among IN cord-005453-4057qib7 9764 2 patients patient NNS cord-005453-4057qib7 9764 3 with with IN cord-005453-4057qib7 9764 4 disseminated disseminate VBN cord-005453-4057qib7 9764 5 infection infection NN cord-005453-4057qib7 9764 6 , , , cord-005453-4057qib7 9764 7 majority majority NN cord-005453-4057qib7 9764 8 had have VBD cord-005453-4057qib7 9764 9 AdV adv NN cord-005453-4057qib7 9764 10 in in IN cord-005453-4057qib7 9764 11 gastro gastro JJ cord-005453-4057qib7 9764 12 - - HYPH cord-005453-4057qib7 9764 13 intestinal(42%),10.5 intestinal(42%),10.5 JJ cord-005453-4057qib7 9764 14 % % NN cord-005453-4057qib7 9764 15 in in IN cord-005453-4057qib7 9764 16 genitourinary genitourinary JJ cord-005453-4057qib7 9764 17 and and CC cord-005453-4057qib7 9764 18 21 21 CD cord-005453-4057qib7 9764 19 % % NN cord-005453-4057qib7 9764 20 as as IN cord-005453-4057qib7 9764 21 both both DT cord-005453-4057qib7 9764 22 sanctuary sanctuary NN cord-005453-4057qib7 9764 23 site site NN cord-005453-4057qib7 9764 24 of of IN cord-005453-4057qib7 9764 25 infection infection NN cord-005453-4057qib7 9764 26 , , , cord-005453-4057qib7 9764 27 in in IN cord-005453-4057qib7 9764 28 addition addition NN cord-005453-4057qib7 9764 29 to to IN cord-005453-4057qib7 9764 30 blood blood NN cord-005453-4057qib7 9764 31 viraemia(85 viraemia(85 NN cord-005453-4057qib7 9764 32 % % NN cord-005453-4057qib7 9764 33 of of IN cord-005453-4057qib7 9764 34 all all DT cord-005453-4057qib7 9764 35 cases).Cumulative cases).cumulative JJ cord-005453-4057qib7 9764 36 incidence incidence NN cord-005453-4057qib7 9764 37 of of IN cord-005453-4057qib7 9764 38 AdV adv NN cord-005453-4057qib7 9764 39 infection infection NN cord-005453-4057qib7 9764 40 was be VBD cord-005453-4057qib7 9764 41 10.6%(95%CI:7.6 10.6%(95%ci:7.6 CD cord-005453-4057qib7 9764 42 - - SYM cord-005453-4057qib7 9764 43 14.2 14.2 CD cord-005453-4057qib7 9764 44 % % NN cord-005453-4057qib7 9764 45 ) ) -RRB- cord-005453-4057qib7 9764 46 at at IN cord-005453-4057qib7 9764 47 12 12 CD cord-005453-4057qib7 9764 48 months month NNS cord-005453-4057qib7 9764 49 with with IN cord-005453-4057qib7 9764 50 median median JJ cord-005453-4057qib7 9764 51 time time NN cord-005453-4057qib7 9764 52 of of IN cord-005453-4057qib7 9764 53 108 108 CD cord-005453-4057qib7 9764 54 days(IQR:19 days(iqr:19 NN cord-005453-4057qib7 9764 55 - - HYPH cord-005453-4057qib7 9764 56 304 304 CD cord-005453-4057qib7 9764 57 days day NNS cord-005453-4057qib7 9764 58 ) ) -RRB- cord-005453-4057qib7 9764 59 to to TO cord-005453-4057qib7 9764 60 detect detect VB cord-005453-4057qib7 9764 61 AdV adv NN cord-005453-4057qib7 9764 62 - - HYPH cord-005453-4057qib7 9764 63 DNA dna NN cord-005453-4057qib7 9764 64 post post NN cord-005453-4057qib7 9764 65 HSCT.Overall hsct.overall NN cord-005453-4057qib7 9764 66 survival(OS survival(os JJ cord-005453-4057qib7 9764 67 ) ) -RRB- cord-005453-4057qib7 9764 68 at at IN cord-005453-4057qib7 9764 69 5 5 CD cord-005453-4057qib7 9764 70 years year NNS cord-005453-4057qib7 9764 71 for for IN cord-005453-4057qib7 9764 72 whole whole JJ cord-005453-4057qib7 9764 73 cohort cohort NN cord-005453-4057qib7 9764 74 was be VBD cord-005453-4057qib7 9764 75 41%(95%CI:31 41%(95%ci:31 CD cord-005453-4057qib7 9764 76 - - HYPH cord-005453-4057qib7 9764 77 50;Median 50;median CD cord-005453-4057qib7 9764 78 OS-57months OS-57months NNP cord-005453-4057qib7 9764 79 ) ) -RRB- cord-005453-4057qib7 9764 80 with with IN cord-005453-4057qib7 9764 81 no no DT cord-005453-4057qib7 9764 82 statistical statistical JJ cord-005453-4057qib7 9764 83 difference difference NN cord-005453-4057qib7 9764 84 between between IN cord-005453-4057qib7 9764 85 patients patient NNS cord-005453-4057qib7 9764 86 with with IN cord-005453-4057qib7 9764 87 disseminated disseminate VBN cord-005453-4057qib7 9764 88 AdV adv NN cord-005453-4057qib7 9764 89 infection infection NN cord-005453-4057qib7 9764 90 vs vs IN cord-005453-4057qib7 9764 91 those those DT cord-005453-4057qib7 9764 92 with with IN cord-005453-4057qib7 9764 93 none(log none(log NN cord-005453-4057qib7 9764 94 rank rank NN cord-005453-4057qib7 9764 95 ; ; : cord-005453-4057qib7 9764 96 p-0.68 p-0.68 NNS cord-005453-4057qib7 9764 97 ; ; : cord-005453-4057qib7 9764 98 Fig-1a fig-1a ADD cord-005453-4057qib7 9764 99 ) ) -RRB- cord-005453-4057qib7 9764 100 . . . cord-005453-4057qib7 9765 1 Overall overall JJ cord-005453-4057qib7 9765 2 cumulative cumulative JJ cord-005453-4057qib7 9765 3 incidence incidence NN cord-005453-4057qib7 9765 4 of of IN cord-005453-4057qib7 9765 5 non non JJ cord-005453-4057qib7 9765 6 - - JJ cord-005453-4057qib7 9765 7 relapse relapse JJ cord-005453-4057qib7 9765 8 mortality mortality NN cord-005453-4057qib7 9765 9 ( ( -LRB- cord-005453-4057qib7 9765 10 NRM NRM NNP cord-005453-4057qib7 9765 11 ) ) -RRB- cord-005453-4057qib7 9765 12 was be VBD cord-005453-4057qib7 9765 13 23%(95%CI:18 23%(95%ci:18 CD cord-005453-4057qib7 9765 14 - - SYM cord-005453-4057qib7 9765 15 28 28 CD cord-005453-4057qib7 9765 16 % % NN cord-005453-4057qib7 9765 17 ) ) -RRB- cord-005453-4057qib7 9765 18 and and CC cord-005453-4057qib7 9765 19 relapse(CIR relapse(CIR NNP cord-005453-4057qib7 9765 20 ) ) -RRB- cord-005453-4057qib7 9765 21 was be VBD cord-005453-4057qib7 9765 22 25.5%(95%CI:19 25.5%(95%ci:19 CD cord-005453-4057qib7 9765 23 - - SYM cord-005453-4057qib7 9765 24 32 32 CD cord-005453-4057qib7 9765 25 % % NN cord-005453-4057qib7 9765 26 ) ) -RRB- cord-005453-4057qib7 9765 27 at at IN cord-005453-4057qib7 9765 28 5 5 CD cord-005453-4057qib7 9765 29 years year NNS cord-005453-4057qib7 9765 30 , , , cord-005453-4057qib7 9765 31 but but CC cord-005453-4057qib7 9765 32 no no DT cord-005453-4057qib7 9765 33 statistical statistical JJ cord-005453-4057qib7 9765 34 difference difference NN cord-005453-4057qib7 9765 35 noted note VBN cord-005453-4057qib7 9765 36 between between IN cord-005453-4057qib7 9765 37 patients patient NNS cord-005453-4057qib7 9765 38 with with IN cord-005453-4057qib7 9765 39 disseminated disseminate VBN cord-005453-4057qib7 9765 40 AdV adv NN cord-005453-4057qib7 9765 41 infection infection NN cord-005453-4057qib7 9765 42 & & CC cord-005453-4057qib7 9765 43 those those DT cord-005453-4057qib7 9765 44 with with IN cord-005453-4057qib7 9765 45 none(NRM none(NRM NNS cord-005453-4057qib7 9765 46 : : : cord-005453-4057qib7 9766 1 p-0.31;CIR p-0.31;CIR NNP cord-005453-4057qib7 9766 2 : : : cord-005453-4057qib7 9767 1 p-0.50;Gray p-0.50;Gray NNP cord-005453-4057qib7 9767 2 test).Pre test).Pre NNP cord-005453-4057qib7 9767 3 - - HYPH cord-005453-4057qib7 9767 4 emptive emptive JJ cord-005453-4057qib7 9767 5 therapy therapy NN cord-005453-4057qib7 9767 6 with with IN cord-005453-4057qib7 9767 7 Cidofovir Cidofovir NNP cord-005453-4057qib7 9767 8 ( ( -LRB- cord-005453-4057qib7 9767 9 3mg 3mg NNP cord-005453-4057qib7 9767 10 / / SYM cord-005453-4057qib7 9767 11 kg kg NNP cord-005453-4057qib7 9767 12 weekly weekly JJ cord-005453-4057qib7 9767 13 IV IV NNP cord-005453-4057qib7 9767 14 infusion infusion NN cord-005453-4057qib7 9767 15 for for IN cord-005453-4057qib7 9767 16 2 2 CD cord-005453-4057qib7 9767 17 weeks week NNS cord-005453-4057qib7 9767 18 and and CC cord-005453-4057qib7 9767 19 fortnightly fortnightly RB cord-005453-4057qib7 9767 20 thereafter thereafter RB cord-005453-4057qib7 9767 21 until until IN cord-005453-4057qib7 9767 22 infection infection NN cord-005453-4057qib7 9767 23 free free JJ cord-005453-4057qib7 9767 24 ) ) -RRB- cord-005453-4057qib7 9767 25 was be VBD cord-005453-4057qib7 9767 26 required require VBN cord-005453-4057qib7 9767 27 in in IN cord-005453-4057qib7 9767 28 33%(14/42 33%(14/42 CD cord-005453-4057qib7 9767 29 ) ) -RRB- cord-005453-4057qib7 9767 30 of of IN cord-005453-4057qib7 9767 31 symptomatic symptomatic JJ cord-005453-4057qib7 9767 32 AdV adv NN cord-005453-4057qib7 9767 33 infection infection NN cord-005453-4057qib7 9767 34 patients patient NNS cord-005453-4057qib7 9767 35 and and CC cord-005453-4057qib7 9767 36 52%(10/19 52%(10/19 CD cord-005453-4057qib7 9767 37 ) ) -RRB- cord-005453-4057qib7 9767 38 with with IN cord-005453-4057qib7 9767 39 disseminated disseminate VBN cord-005453-4057qib7 9767 40 infections infection NNS cord-005453-4057qib7 9767 41 . . . cord-005453-4057qib7 9768 1 One one CD cord-005453-4057qib7 9768 2 patient patient NN cord-005453-4057qib7 9768 3 required require VBN cord-005453-4057qib7 9768 4 brincidofovir brincidofovir NNS cord-005453-4057qib7 9768 5 therapy therapy NN cord-005453-4057qib7 9768 6 for for IN cord-005453-4057qib7 9768 7 refractory refractory JJ cord-005453-4057qib7 9768 8 disease disease NN cord-005453-4057qib7 9768 9 , , , cord-005453-4057qib7 9768 10 but but CC cord-005453-4057qib7 9768 11 one one CD cord-005453-4057qib7 9768 12 patient patient NN cord-005453-4057qib7 9768 13 died die VBD cord-005453-4057qib7 9768 14 due due IN cord-005453-4057qib7 9768 15 to to IN cord-005453-4057qib7 9768 16 severe severe JJ cord-005453-4057qib7 9768 17 sepsis sepsis NN cord-005453-4057qib7 9768 18 , , , cord-005453-4057qib7 9768 19 before before IN cord-005453-4057qib7 9768 20 AdV adv NN cord-005453-4057qib7 9768 21 specific specific JJ cord-005453-4057qib7 9768 22 therapy therapy NN cord-005453-4057qib7 9768 23 could could MD cord-005453-4057qib7 9768 24 be be VB cord-005453-4057qib7 9768 25 given give VBN cord-005453-4057qib7 9768 26 . . . cord-005453-4057qib7 9769 1 Remaining remain VBG cord-005453-4057qib7 9769 2 patients patient NNS cord-005453-4057qib7 9769 3 were be VBD cord-005453-4057qib7 9769 4 monitored monitor VBN cord-005453-4057qib7 9769 5 and and CC cord-005453-4057qib7 9769 6 all all DT cord-005453-4057qib7 9769 7 self self NN cord-005453-4057qib7 9769 8 - - HYPH cord-005453-4057qib7 9769 9 recovered recover VBN cord-005453-4057qib7 9769 10 on on IN cord-005453-4057qib7 9769 11 cessation cessation NN cord-005453-4057qib7 9769 12 of of IN cord-005453-4057qib7 9769 13 immunosuppression immunosuppression NN cord-005453-4057qib7 9769 14 . . . cord-005453-4057qib7 9770 1 All all DT cord-005453-4057qib7 9770 2 patients patient NNS cord-005453-4057qib7 9770 3 treated treat VBN cord-005453-4057qib7 9770 4 with with IN cord-005453-4057qib7 9770 5 cidofovir cidofovir NNS cord-005453-4057qib7 9770 6 developed develop VBD cord-005453-4057qib7 9770 7 renal renal JJ cord-005453-4057qib7 9770 8 impairment(defined impairment(define VBN cord-005453-4057qib7 9770 9 by by IN cord-005453-4057qib7 9770 10 atleast atleast NN cord-005453-4057qib7 9770 11 > > XX cord-005453-4057qib7 9770 12 25 25 CD cord-005453-4057qib7 9770 13 % % NN cord-005453-4057qib7 9770 14 increase increase NN cord-005453-4057qib7 9770 15 in in IN cord-005453-4057qib7 9770 16 baseline baseline NN cord-005453-4057qib7 9770 17 creatinine),however creatinine),however NNP cord-005453-4057qib7 9770 18 majority(73 majority(73 NNP cord-005453-4057qib7 9770 19 % % NN cord-005453-4057qib7 9770 20 ) ) -RRB- cord-005453-4057qib7 9770 21 recovered recover VBD cord-005453-4057qib7 9770 22 their -PRON- PRP$ cord-005453-4057qib7 9770 23 renal renal JJ cord-005453-4057qib7 9770 24 function function NN cord-005453-4057qib7 9770 25 near near IN cord-005453-4057qib7 9770 26 their -PRON- PRP$ cord-005453-4057qib7 9770 27 baseline baseline NN cord-005453-4057qib7 9770 28 ( ( -LRB- cord-005453-4057qib7 9770 29 Fig-1b Fig-1b NNP cord-005453-4057qib7 9770 30 ) ) -RRB- cord-005453-4057qib7 9770 31 . . . cord-005453-4057qib7 9771 1 Conclusions conclusion NNS cord-005453-4057qib7 9771 2 : : : cord-005453-4057qib7 9772 1 AdV AdV NNP cord-005453-4057qib7 9772 2 infection infection NN cord-005453-4057qib7 9772 3 remains remain VBZ cord-005453-4057qib7 9772 4 a a DT cord-005453-4057qib7 9772 5 significant significant JJ cord-005453-4057qib7 9772 6 cause cause NN cord-005453-4057qib7 9772 7 of of IN cord-005453-4057qib7 9772 8 morbidity morbidity NN cord-005453-4057qib7 9772 9 in in IN cord-005453-4057qib7 9772 10 adult adult NN cord-005453-4057qib7 9772 11 HSCT HSCT NNP cord-005453-4057qib7 9772 12 patients patient NNS cord-005453-4057qib7 9772 13 , , , cord-005453-4057qib7 9772 14 however however RB cord-005453-4057qib7 9772 15 pre pre JJ cord-005453-4057qib7 9772 16 - - JJ cord-005453-4057qib7 9772 17 emptive emptive JJ cord-005453-4057qib7 9772 18 management management NN cord-005453-4057qib7 9772 19 with with IN cord-005453-4057qib7 9772 20 cidofovir cidofovir NNP cord-005453-4057qib7 9772 21 has have VBZ cord-005453-4057qib7 9772 22 improved improve VBN cord-005453-4057qib7 9772 23 OS OS NNP cord-005453-4057qib7 9772 24 and and CC cord-005453-4057qib7 9772 25 NRM NRM NNP cord-005453-4057qib7 9772 26 despite despite IN cord-005453-4057qib7 9772 27 use use NN cord-005453-4057qib7 9772 28 of of IN cord-005453-4057qib7 9772 29 TCD TCD NNP cord-005453-4057qib7 9772 30 conditioning conditioning NN cord-005453-4057qib7 9772 31 . . . cord-005453-4057qib7 9773 1 Renal renal JJ cord-005453-4057qib7 9773 2 toxicity toxicity NN cord-005453-4057qib7 9773 3 remains remain VBZ cord-005453-4057qib7 9773 4 common common JJ cord-005453-4057qib7 9773 5 with with IN cord-005453-4057qib7 9773 6 cidofovir cidofovir NNS cord-005453-4057qib7 9773 7 but but CC cord-005453-4057qib7 9773 8 with with IN cord-005453-4057qib7 9773 9 use use NN cord-005453-4057qib7 9773 10 of of IN cord-005453-4057qib7 9773 11 intermediate intermediate JJ cord-005453-4057qib7 9773 12 doses dose NNS cord-005453-4057qib7 9773 13 , , , cord-005453-4057qib7 9773 14 majority majority NN cord-005453-4057qib7 9773 15 do do VBP cord-005453-4057qib7 9773 16 recover recover VB cord-005453-4057qib7 9773 17 their -PRON- PRP$ cord-005453-4057qib7 9773 18 renal renal JJ cord-005453-4057qib7 9773 19 functions function NNS cord-005453-4057qib7 9773 20 . . . cord-005453-4057qib7 9774 1 Clinical clinical JJ cord-005453-4057qib7 9774 2 Trial Trial NNP cord-005453-4057qib7 9774 3 Registry Registry NNP cord-005453-4057qib7 9774 4 : : : cord-005453-4057qib7 9775 1 n n LS cord-005453-4057qib7 9775 2 / / SYM cord-005453-4057qib7 9775 3 a a DT cord-005453-4057qib7 9775 4 Disclosure disclosure NN cord-005453-4057qib7 9775 5 : : : cord-005453-4057qib7 9775 6 Nothing nothing NN cord-005453-4057qib7 9775 7 to to TO cord-005453-4057qib7 9775 8 declare declare VB cord-005453-4057qib7 9775 9 Background background NN cord-005453-4057qib7 9775 10 : : : cord-005453-4057qib7 9775 11 Publications publication NNS cord-005453-4057qib7 9775 12 on on IN cord-005453-4057qib7 9775 13 invasive invasive JJ cord-005453-4057qib7 9775 14 fungal fungal NN cord-005453-4057qib7 9775 15 disease disease NN cord-005453-4057qib7 9775 16 ( ( -LRB- cord-005453-4057qib7 9775 17 IFD IFD NNP cord-005453-4057qib7 9775 18 ) ) -RRB- cord-005453-4057qib7 9775 19 in in IN cord-005453-4057qib7 9775 20 lymphoma lymphoma NN cord-005453-4057qib7 9775 21 patients patient NNS cord-005453-4057qib7 9775 22 are be VBP cord-005453-4057qib7 9775 23 limited limit VBN cord-005453-4057qib7 9775 24 especially especially RB cord-005453-4057qib7 9775 25 after after IN cord-005453-4057qib7 9775 26 allo allo NN cord-005453-4057qib7 9775 27 - - HYPH cord-005453-4057qib7 9775 28 HSCT HSCT NNP cord-005453-4057qib7 9775 29 . . . cord-005453-4057qib7 9776 1 There there EX cord-005453-4057qib7 9776 2 are be VBP cord-005453-4057qib7 9776 3 no no DT cord-005453-4057qib7 9776 4 data data NN cord-005453-4057qib7 9776 5 on on IN cord-005453-4057qib7 9776 6 outcome outcome NN cord-005453-4057qib7 9776 7 of of IN cord-005453-4057qib7 9776 8 allo allo NN cord-005453-4057qib7 9776 9 - - HYPH cord-005453-4057qib7 9776 10 HSCT HSCT NNP cord-005453-4057qib7 9776 11 in in IN cord-005453-4057qib7 9776 12 lymphoma lymphoma NN cord-005453-4057qib7 9776 13 patients patient NNS cord-005453-4057qib7 9776 14 with with IN cord-005453-4057qib7 9776 15 prior prior JJ cord-005453-4057qib7 9776 16 IFD IFD NNP cord-005453-4057qib7 9776 17 . . . cord-005453-4057qib7 9777 1 This this DT cord-005453-4057qib7 9777 2 study study NN cord-005453-4057qib7 9777 3 focuses focus VBZ cord-005453-4057qib7 9777 4 on on IN cord-005453-4057qib7 9777 5 epidemiology epidemiology NN cord-005453-4057qib7 9777 6 of of IN cord-005453-4057qib7 9777 7 IFD IFD NNP cord-005453-4057qib7 9777 8 before before IN cord-005453-4057qib7 9777 9 and and CC cord-005453-4057qib7 9777 10 after after IN cord-005453-4057qib7 9777 11 allo allo NN cord-005453-4057qib7 9777 12 - - HYPH cord-005453-4057qib7 9777 13 HSCT HSCT NNP cord-005453-4057qib7 9777 14 in in IN cord-005453-4057qib7 9777 15 children child NNS cord-005453-4057qib7 9777 16 and and CC cord-005453-4057qib7 9777 17 adults adult NNS cord-005453-4057qib7 9777 18 with with IN cord-005453-4057qib7 9777 19 Hodgkin Hodgkin NNP cord-005453-4057qib7 9777 20 's 's POS cord-005453-4057qib7 9777 21 lymphoma lymphoma NN cord-005453-4057qib7 9777 22 ( ( -LRB- cord-005453-4057qib7 9777 23 HL HL NNP cord-005453-4057qib7 9777 24 ) ) -RRB- cord-005453-4057qib7 9777 25 . . . cord-005453-4057qib7 9778 1 Methods method NNS cord-005453-4057qib7 9778 2 : : : cord-005453-4057qib7 9778 3 Single single JJ cord-005453-4057qib7 9778 4 center center NN cord-005453-4057qib7 9778 5 prospective prospective JJ cord-005453-4057qib7 9778 6 study study NN cord-005453-4057qib7 9778 7 included include VBD cord-005453-4057qib7 9778 8 86 86 CD cord-005453-4057qib7 9778 9 patients patient NNS cord-005453-4057qib7 9778 10 with with IN cord-005453-4057qib7 9778 11 classical classical JJ cord-005453-4057qib7 9778 12 r r NN cord-005453-4057qib7 9778 13 / / SYM cord-005453-4057qib7 9778 14 r r NN cord-005453-4057qib7 9778 15 HL HL NNP cord-005453-4057qib7 9778 16 who who WP cord-005453-4057qib7 9778 17 received receive VBD cord-005453-4057qib7 9778 18 allo allo NN cord-005453-4057qib7 9778 19 - - HYPH cord-005453-4057qib7 9778 20 HSCT HSCT NNP cord-005453-4057qib7 9778 21 from from IN cord-005453-4057qib7 9778 22 2002 2002 CD cord-005453-4057qib7 9778 23 to to IN cord-005453-4057qib7 9778 24 2018 2018 CD cord-005453-4057qib7 9778 25 . . . cord-005453-4057qib7 9779 1 The the DT cord-005453-4057qib7 9779 2 median median JJ cord-005453-4057qib7 9779 3 age age NN cord-005453-4057qib7 9779 4 was be VBD cord-005453-4057qib7 9779 5 27 27 CD cord-005453-4057qib7 9779 6 ( ( -LRB- cord-005453-4057qib7 9779 7 13 13 CD cord-005453-4057qib7 9779 8 - - SYM cord-005453-4057qib7 9779 9 49 49 CD cord-005453-4057qib7 9779 10 ) ) -RRB- cord-005453-4057qib7 9779 11 y.o y.o NNP cord-005453-4057qib7 9779 12 . . NNP cord-005453-4057qib7 9779 13 , , , cord-005453-4057qib7 9779 14 children child NNS cord-005453-4057qib7 9779 15 ( ( -LRB- cord-005453-4057qib7 9779 16 < < NNP cord-005453-4057qib7 9779 17 18 18 CD cord-005453-4057qib7 9779 18 yo yo NNS cord-005453-4057qib7 9779 19 ) ) -RRB- cord-005453-4057qib7 9779 20 -13 -13 CD cord-005453-4057qib7 9779 21 % % NN cord-005453-4057qib7 9779 22 . . . cord-005453-4057qib7 9780 1 Allo Allo NNP cord-005453-4057qib7 9780 2 - - HYPH cord-005453-4057qib7 9780 3 HSCT HSCT NNP cord-005453-4057qib7 9780 4 from from IN cord-005453-4057qib7 9780 5 MUD MUD NNP cord-005453-4057qib7 9780 6 was be VBD cord-005453-4057qib7 9780 7 performed perform VBN cord-005453-4057qib7 9780 8 in in IN cord-005453-4057qib7 9780 9 45,4 45,4 CD cord-005453-4057qib7 9780 10 % % NN cord-005453-4057qib7 9780 11 ( ( -LRB- cord-005453-4057qib7 9780 12 n=39 n=39 NNP cord-005453-4057qib7 9780 13 ) ) -RRB- cord-005453-4057qib7 9780 14 , , , cord-005453-4057qib7 9780 15 MRD MRD NNP cord-005453-4057qib7 9780 16 -24,4 -24,4 NNP cord-005453-4057qib7 9780 17 % % NN cord-005453-4057qib7 9780 18 ( ( -LRB- cord-005453-4057qib7 9780 19 n=21 n=21 NNP cord-005453-4057qib7 9780 20 ) ) -RRB- cord-005453-4057qib7 9780 21 , , , cord-005453-4057qib7 9780 22 MMUD MMUD NNP cord-005453-4057qib7 9780 23 -15,1 -15,1 IN cord-005453-4057qib7 9780 24 % % NN cord-005453-4057qib7 9780 25 ( ( -LRB- cord-005453-4057qib7 9780 26 n=13 n=13 NNP cord-005453-4057qib7 9780 27 ) ) -RRB- cord-005453-4057qib7 9780 28 , , , cord-005453-4057qib7 9780 29 haplo haplo NNP cord-005453-4057qib7 9780 30 -15,1 -15,1 NNP cord-005453-4057qib7 9780 31 % % NN cord-005453-4057qib7 9780 32 ( ( -LRB- cord-005453-4057qib7 9780 33 n=13 n=13 NNP cord-005453-4057qib7 9780 34 ) ) -RRB- cord-005453-4057qib7 9780 35 , , , cord-005453-4057qib7 9780 36 with with IN cord-005453-4057qib7 9780 37 RIC RIC NNP cord-005453-4057qib7 9780 38 ( ( -LRB- cord-005453-4057qib7 9780 39 100 100 CD cord-005453-4057qib7 9780 40 % % NN cord-005453-4057qib7 9780 41 ) ) -RRB- cord-005453-4057qib7 9780 42 and and CC cord-005453-4057qib7 9780 43 predominantly predominantly RB cord-005453-4057qib7 9780 44 PTCY PTCY NNP cord-005453-4057qib7 9780 45 - - HYPH cord-005453-4057qib7 9780 46 based base VBN cord-005453-4057qib7 9780 47 GvHD GvHD NNP cord-005453-4057qib7 9780 48 prophylaxis prophylaxis NN cord-005453-4057qib7 9780 49 ( ( -LRB- cord-005453-4057qib7 9780 50 71 71 CD cord-005453-4057qib7 9780 51 % % NN cord-005453-4057qib7 9780 52 ) ) -RRB- cord-005453-4057qib7 9780 53 . . . cord-005453-4057qib7 9781 1 Primary primary JJ cord-005453-4057qib7 9781 2 antifungal antifungal JJ cord-005453-4057qib7 9781 3 prophylaxis prophylaxis NN cord-005453-4057qib7 9781 4 was be VBD cord-005453-4057qib7 9781 5 fluconazole fluconazole NN cord-005453-4057qib7 9781 6 in in IN cord-005453-4057qib7 9781 7 85 85 CD cord-005453-4057qib7 9781 8 % % NN cord-005453-4057qib7 9781 9 , , , cord-005453-4057qib7 9781 10 secondary secondary JJ cord-005453-4057qib7 9781 11 -voriconazole -voriconazole NN cord-005453-4057qib7 9782 1 ( ( -LRB- cord-005453-4057qib7 9782 2 100 100 CD cord-005453-4057qib7 9782 3 % % NN cord-005453-4057qib7 9782 4 ) ) -RRB- cord-005453-4057qib7 9782 5 . . . cord-005453-4057qib7 9783 1 EORTC EORTC NNP cord-005453-4057qib7 9783 2 / / SYM cord-005453-4057qib7 9783 3 MSG MSG NNP cord-005453-4057qib7 9783 4 2008 2008 CD cord-005453-4057qib7 9783 5 criteria criterion NNS cord-005453-4057qib7 9783 6 for for IN cord-005453-4057qib7 9783 7 diagnosis diagnosis NN cord-005453-4057qib7 9783 8 and and CC cord-005453-4057qib7 9783 9 bronchoscopy bronchoscopy NN cord-005453-4057qib7 9783 10 before before IN cord-005453-4057qib7 9783 11 allo allo NN cord-005453-4057qib7 9783 12 - - HYPH cord-005453-4057qib7 9783 13 HSCT HSCT NNP cord-005453-4057qib7 9783 14 in in IN cord-005453-4057qib7 9783 15 pts pts NN cord-005453-4057qib7 9783 16 with with IN cord-005453-4057qib7 9783 17 CT CT NNP cord-005453-4057qib7 9783 18 - - HYPH cord-005453-4057qib7 9783 19 scan scan JJ cord-005453-4057qib7 9783 20 lung lung NN cord-005453-4057qib7 9783 21 lesions lesion NNS cord-005453-4057qib7 9783 22 were be VBD cord-005453-4057qib7 9783 23 used use VBN cord-005453-4057qib7 9783 24 . . . cord-005453-4057qib7 9784 1 " " '' cord-005453-4057qib7 9785 1 Active active JJ cord-005453-4057qib7 9785 2 IFD IFD NNP cord-005453-4057qib7 9785 3 " " '' cord-005453-4057qib7 9785 4 means mean VBZ cord-005453-4057qib7 9785 5 IFD IFD NNP cord-005453-4057qib7 9785 6 diagnosed diagnose VBN cord-005453-4057qib7 9785 7 just just RB cord-005453-4057qib7 9785 8 before before IN cord-005453-4057qib7 9785 9 HSCT HSCT NNP cord-005453-4057qib7 9785 10 . . . cord-005453-4057qib7 9786 1 Median median JJ cord-005453-4057qib7 9786 2 follow follow NN cord-005453-4057qib7 9786 3 - - HYPH cord-005453-4057qib7 9786 4 up up RP cord-005453-4057qib7 9786 5 time time NN cord-005453-4057qib7 9786 6 was be VBD cord-005453-4057qib7 9786 7 12 12 CD cord-005453-4057qib7 9786 8 months month NNS cord-005453-4057qib7 9786 9 . . . cord-005453-4057qib7 9787 1 Results result NNS cord-005453-4057qib7 9787 2 : : : cord-005453-4057qib7 9787 3 Incidence incidence NN cord-005453-4057qib7 9787 4 of of IN cord-005453-4057qib7 9787 5 IFD IFD NNP cord-005453-4057qib7 9787 6 before before IN cord-005453-4057qib7 9787 7 allo allo NN cord-005453-4057qib7 9787 8 - - HYPH cord-005453-4057qib7 9787 9 HSCT HSCT NNP cord-005453-4057qib7 9787 10 was be VBD cord-005453-4057qib7 9787 11 12,8 12,8 CD cord-005453-4057qib7 9787 12 % % NN cord-005453-4057qib7 9787 13 ( ( -LRB- cord-005453-4057qib7 9787 14 n=11 n=11 NNP cord-005453-4057qib7 9787 15 ) ) -RRB- cord-005453-4057qib7 9787 16 . . . cord-005453-4057qib7 9788 1 IFD IFD NNP cord-005453-4057qib7 9788 2 prior prior RB cord-005453-4057qib7 9788 3 to to IN cord-005453-4057qib7 9788 4 HSCT HSCT NNP cord-005453-4057qib7 9788 5 were be VBD cord-005453-4057qib7 9788 6 invasive invasive JJ cord-005453-4057qib7 9788 7 aspergillosis aspergillosis NN cord-005453-4057qib7 9788 8 ( ( -LRB- cord-005453-4057qib7 9788 9 IA IA NNP cord-005453-4057qib7 9788 10 ) ) -RRB- cord-005453-4057qib7 9788 11 with with IN cord-005453-4057qib7 9788 12 lungs lung NNS cord-005453-4057qib7 9788 13 involvement involvement NN cord-005453-4057qib7 9788 14 . . . cord-005453-4057qib7 9789 1 Antifungal antifungal JJ cord-005453-4057qib7 9789 2 therapy therapy NN cord-005453-4057qib7 9789 3 before before IN cord-005453-4057qib7 9789 4 allo allo NN cord-005453-4057qib7 9789 5 - - HYPH cord-005453-4057qib7 9789 6 HSCT HSCT NNP cord-005453-4057qib7 9789 7 was be VBD cord-005453-4057qib7 9789 8 used use VBN cord-005453-4057qib7 9789 9 in in IN cord-005453-4057qib7 9789 10 81,8 81,8 CD cord-005453-4057qib7 9789 11 % % NN cord-005453-4057qib7 9789 12 pts pts NN cord-005453-4057qib7 9789 13 with with IN cord-005453-4057qib7 9789 14 median median JJ cord-005453-4057qib7 9789 15 duration duration NN cord-005453-4057qib7 9789 16 -2 -2 CD cord-005453-4057qib7 9789 17 months month NNS cord-005453-4057qib7 9789 18 . . . cord-005453-4057qib7 9790 1 Complete complete JJ cord-005453-4057qib7 9790 2 response response NN cord-005453-4057qib7 9790 3 to to IN cord-005453-4057qib7 9790 4 antifungal antifungal JJ cord-005453-4057qib7 9790 5 therapy therapy NN cord-005453-4057qib7 9790 6 was be VBD cord-005453-4057qib7 9790 7 in in IN cord-005453-4057qib7 9790 8 45,4 45,4 CD cord-005453-4057qib7 9790 9 % % NN cord-005453-4057qib7 9790 10 pts pt NNS cord-005453-4057qib7 9790 11 , , , cord-005453-4057qib7 9790 12 partial partial JJ cord-005453-4057qib7 9790 13 response response NN cord-005453-4057qib7 9790 14 or or CC cord-005453-4057qib7 9790 15 stabilization stabilization NN cord-005453-4057qib7 9790 16 -36,4 -36,4 NN cord-005453-4057qib7 9790 17 % % NN cord-005453-4057qib7 9790 18 , , , cord-005453-4057qib7 9790 19 and and CC cord-005453-4057qib7 9790 20 18,2 18,2 CD cord-005453-4057qib7 9790 21 % % NN cord-005453-4057qib7 9790 22 pts pt NNS cord-005453-4057qib7 9790 23 had have VBD cord-005453-4057qib7 9790 24 an an DT cord-005453-4057qib7 9790 25 " " `` cord-005453-4057qib7 9790 26 active active JJ cord-005453-4057qib7 9790 27 IFD ifd NN cord-005453-4057qib7 9790 28 " " '' cord-005453-4057qib7 9790 29 . . . cord-005453-4057qib7 9791 1 After after IN cord-005453-4057qib7 9791 2 allo allo NN cord-005453-4057qib7 9791 3 - - HYPH cord-005453-4057qib7 9791 4 HSCT HSCT NNP cord-005453-4057qib7 9791 5 all all DT cord-005453-4057qib7 9791 6 pts pts NN cord-005453-4057qib7 9791 7 received receive VBD cord-005453-4057qib7 9791 8 voriconazole voriconazole NN cord-005453-4057qib7 9791 9 as as IN cord-005453-4057qib7 9791 10 an an DT cord-005453-4057qib7 9791 11 antifungal antifungal JJ cord-005453-4057qib7 9791 12 therapy therapy NN cord-005453-4057qib7 9791 13 or or CC cord-005453-4057qib7 9791 14 secondary secondary JJ cord-005453-4057qib7 9791 15 prophylaxis prophylaxis NN cord-005453-4057qib7 9791 16 . . . cord-005453-4057qib7 9792 1 Cumulative cumulative JJ cord-005453-4057qib7 9792 2 incidence incidence NN cord-005453-4057qib7 9792 3 of of IN cord-005453-4057qib7 9792 4 relapse relapse NN cord-005453-4057qib7 9792 5 or or CC cord-005453-4057qib7 9792 6 progression progression NN cord-005453-4057qib7 9792 7 of of IN cord-005453-4057qib7 9792 8 IA IA NNP cord-005453-4057qib7 9792 9 after after IN cord-005453-4057qib7 9792 10 allo allo NNP cord-005453-4057qib7 9792 11 - - HYPH cord-005453-4057qib7 9792 12 HSCT HSCT NNP cord-005453-4057qib7 9792 13 was be VBD cord-005453-4057qib7 9792 14 18,2 18,2 CD cord-005453-4057qib7 9792 15 % % NN cord-005453-4057qib7 9792 16 with with IN cord-005453-4057qib7 9792 17 the the DT cord-005453-4057qib7 9792 18 median median JJ cord-005453-4057qib7 9792 19 49 49 CD cord-005453-4057qib7 9792 20 day day NN cord-005453-4057qib7 9792 21 after after IN cord-005453-4057qib7 9792 22 HSCT HSCT NNP cord-005453-4057qib7 9792 23 , , , cord-005453-4057qib7 9792 24 which which WDT cord-005453-4057qib7 9792 25 were be VBD cord-005453-4057qib7 9792 26 successfully successfully RB cord-005453-4057qib7 9792 27 treated treat VBN cord-005453-4057qib7 9792 28 with with IN cord-005453-4057qib7 9792 29 voriconazole voriconazole NNP cord-005453-4057qib7 9792 30 in in IN cord-005453-4057qib7 9792 31 post post NN cord-005453-4057qib7 9792 32 HSCT HSCT NNP cord-005453-4057qib7 9792 33 period period NN cord-005453-4057qib7 9792 34 . . . cord-005453-4057qib7 9793 1 Incidence incidence NN cord-005453-4057qib7 9793 2 of of IN cord-005453-4057qib7 9793 3 IFD IFD NNP cord-005453-4057qib7 9793 4 after after IN cord-005453-4057qib7 9793 5 allo allo NN cord-005453-4057qib7 9793 6 - - HYPH cord-005453-4057qib7 9793 7 HSCT HSCT NNP cord-005453-4057qib7 9793 8 for for IN cord-005453-4057qib7 9793 9 naïve naïve JJ cord-005453-4057qib7 9793 10 patients patient NNS cord-005453-4057qib7 9793 11 was be VBD cord-005453-4057qib7 9793 12 17,6 17,6 CD cord-005453-4057qib7 9793 13 % % NN cord-005453-4057qib7 9793 14 ( ( -LRB- cord-005453-4057qib7 9793 15 n=13/74 n=13/74 CD cord-005453-4057qib7 9793 16 ) ) -RRB- cord-005453-4057qib7 9793 17 . . . cord-005453-4057qib7 9794 1 Etiology etiology NN cord-005453-4057qib7 9794 2 of of IN cord-005453-4057qib7 9794 3 IFD IFD NNP cord-005453-4057qib7 9794 4 after after IN cord-005453-4057qib7 9794 5 allo allo NN cord-005453-4057qib7 9794 6 - - HYPH cord-005453-4057qib7 9794 7 HSCT HSCT NNP cord-005453-4057qib7 9794 8 was be VBD cord-005453-4057qib7 9794 9 IA IA NNP cord-005453-4057qib7 9794 10 -69 -69 NNP cord-005453-4057qib7 9794 11 % % NN cord-005453-4057qib7 9794 12 , , , cord-005453-4057qib7 9794 13 invasive invasive JJ cord-005453-4057qib7 9794 14 candidiasis candidiasis NN cord-005453-4057qib7 9794 15 ( ( -LRB- cord-005453-4057qib7 9794 16 IC IC NNP cord-005453-4057qib7 9794 17 ) ) -RRB- cord-005453-4057qib7 9794 18 -15 -15 CD cord-005453-4057qib7 9794 19 % % NN cord-005453-4057qib7 9794 20 , , , cord-005453-4057qib7 9794 21 mucormycosis mucormycosis NN cord-005453-4057qib7 9794 22 -8 -8 NNP cord-005453-4057qib7 9794 23 % % NN cord-005453-4057qib7 9794 24 and and CC cord-005453-4057qib7 9794 25 8 8 CD cord-005453-4057qib7 9794 26 % % NN cord-005453-4057qib7 9794 27 combined combine VBN cord-005453-4057qib7 9794 28 IFD IFD NNP cord-005453-4057qib7 9794 29 caused cause VBN cord-005453-4057qib7 9794 30 by by IN cord-005453-4057qib7 9794 31 Aspergillus aspergillus NN cord-005453-4057qib7 9794 32 fumigatus fumigatus NN cord-005453-4057qib7 9794 33 + + CC cord-005453-4057qib7 9794 34 Rhizopus Rhizopus NNP cord-005453-4057qib7 9794 35 stolonifer stolonifer NN cord-005453-4057qib7 9794 36 . . . cord-005453-4057qib7 9795 1 The the DT cord-005453-4057qib7 9795 2 median median JJ cord-005453-4057qib7 9795 3 day day NN cord-005453-4057qib7 9795 4 of of IN cord-005453-4057qib7 9795 5 onset onset NN cord-005453-4057qib7 9795 6 of of IN cord-005453-4057qib7 9795 7 IFD IFD NNP cord-005453-4057qib7 9795 8 after after IN cord-005453-4057qib7 9795 9 allo allo NN cord-005453-4057qib7 9795 10 - - HYPH cord-005453-4057qib7 9795 11 HSCT HSCT NNP cord-005453-4057qib7 9795 12 was be VBD cord-005453-4057qib7 9795 13 day+ day+ NNP cord-005453-4057qib7 9795 14 114 114 CD cord-005453-4057qib7 9795 15 and and CC cord-005453-4057qib7 9795 16 was be VBD cord-005453-4057qib7 9795 17 associated associate VBN cord-005453-4057qib7 9795 18 with with IN cord-005453-4057qib7 9795 19 post post JJ cord-005453-4057qib7 9795 20 - - JJ cord-005453-4057qib7 9795 21 HSCT hsct JJ cord-005453-4057qib7 9795 22 relapse relapse NN cord-005453-4057qib7 9795 23 of of IN cord-005453-4057qib7 9795 24 HL HL NNP cord-005453-4057qib7 9795 25 ( ( -LRB- cord-005453-4057qib7 9795 26 p=0,04 p=0,04 NNP cord-005453-4057qib7 9795 27 ) ) -RRB- cord-005453-4057qib7 9795 28 . . . cord-005453-4057qib7 9796 1 The the DT cord-005453-4057qib7 9796 2 main main JJ cord-005453-4057qib7 9796 3 site site NN cord-005453-4057qib7 9796 4 of of IN cord-005453-4057qib7 9796 5 infection infection NN cord-005453-4057qib7 9796 6 were be VBD cord-005453-4057qib7 9796 7 lungs lung NNS cord-005453-4057qib7 9796 8 ( ( -LRB- cord-005453-4057qib7 9796 9 88 88 CD cord-005453-4057qib7 9796 10 % % NN cord-005453-4057qib7 9796 11 ) ) -RRB- cord-005453-4057qib7 9796 12 , , , cord-005453-4057qib7 9796 13 the the DT cord-005453-4057qib7 9796 14 main main JJ cord-005453-4057qib7 9796 15 clinical clinical JJ cord-005453-4057qib7 9796 16 symptom symptom NN cord-005453-4057qib7 9796 17 -febrile -febrile NN cord-005453-4057qib7 9796 18 fever fever NN cord-005453-4057qib7 9796 19 ( ( -LRB- cord-005453-4057qib7 9796 20 100 100 CD cord-005453-4057qib7 9796 21 % % NN cord-005453-4057qib7 9796 22 ) ) -RRB- cord-005453-4057qib7 9796 23 . . . cord-005453-4057qib7 9797 1 Antifungal antifungal JJ cord-005453-4057qib7 9797 2 therapy therapy NN cord-005453-4057qib7 9797 3 was be VBD cord-005453-4057qib7 9797 4 used use VBN cord-005453-4057qib7 9797 5 in in IN cord-005453-4057qib7 9797 6 all all DT cord-005453-4057qib7 9797 7 patients patient NNS cord-005453-4057qib7 9797 8 : : : cord-005453-4057qib7 9797 9 voriconazole voriconazole NNP cord-005453-4057qib7 9797 10 -59 -59 NNP cord-005453-4057qib7 9797 11 % % NN cord-005453-4057qib7 9797 12 , , , cord-005453-4057qib7 9797 13 micafungin micafungin NNP cord-005453-4057qib7 9797 14 -17 -17 CD cord-005453-4057qib7 9797 15 % % NN cord-005453-4057qib7 9797 16 , , , cord-005453-4057qib7 9797 17 posaconazole posaconazole NNP cord-005453-4057qib7 9797 18 -8 -8 NNP cord-005453-4057qib7 9797 19 % % NN cord-005453-4057qib7 9797 20 , , , cord-005453-4057qib7 9797 21 lipid lipid NN cord-005453-4057qib7 9797 22 amphotericin amphotericin NNS cord-005453-4057qib7 9797 23 B b NN cord-005453-4057qib7 9797 24 -8 -8 NNP cord-005453-4057qib7 9797 25 % % NN cord-005453-4057qib7 9797 26 and and CC cord-005453-4057qib7 9797 27 combination combination NN cord-005453-4057qib7 9797 28 lipid lipid NN cord-005453-4057qib7 9797 29 amphotericin amphotericin NNS cord-005453-4057qib7 9797 30 B B NNP cord-005453-4057qib7 9797 31 with with IN cord-005453-4057qib7 9797 32 caspofungin caspofungin NNP cord-005453-4057qib7 9797 33 -8 -8 NNP cord-005453-4057qib7 9797 34 % % NN cord-005453-4057qib7 9797 35 . . . cord-005453-4057qib7 9798 1 Overall overall JJ cord-005453-4057qib7 9798 2 survival survival NN cord-005453-4057qib7 9798 3 ( ( -LRB- cord-005453-4057qib7 9798 4 OS OS NNP cord-005453-4057qib7 9798 5 ) ) -RRB- cord-005453-4057qib7 9798 6 at at IN cord-005453-4057qib7 9798 7 12 12 CD cord-005453-4057qib7 9798 8 weeks week NNS cord-005453-4057qib7 9798 9 from from IN cord-005453-4057qib7 9798 10 the the DT cord-005453-4057qib7 9798 11 diagnosis diagnosis NN cord-005453-4057qib7 9798 12 of of IN cord-005453-4057qib7 9798 13 IFD IFD NNP cord-005453-4057qib7 9798 14 after after IN cord-005453-4057qib7 9798 15 allo allo NN cord-005453-4057qib7 9798 16 - - HYPH cord-005453-4057qib7 9798 17 HSCT HSCT NNP cord-005453-4057qib7 9798 18 was be VBD cord-005453-4057qib7 9798 19 80 80 CD cord-005453-4057qib7 9798 20 % % NN cord-005453-4057qib7 9798 21 . . . cord-005453-4057qib7 9799 1 The the DT cord-005453-4057qib7 9799 2 2-year 2-year CD cord-005453-4057qib7 9799 3 OS os NN cord-005453-4057qib7 9799 4 in in IN cord-005453-4057qib7 9799 5 children child NNS cord-005453-4057qib7 9799 6 and and CC cord-005453-4057qib7 9799 7 adult adult NN cord-005453-4057qib7 9799 8 with with IN cord-005453-4057qib7 9799 9 HL HL NNP cord-005453-4057qib7 9799 10 after after IN cord-005453-4057qib7 9799 11 allo allo NN cord-005453-4057qib7 9799 12 - - HYPH cord-005453-4057qib7 9799 13 HSCT HSCT NNP cord-005453-4057qib7 9799 14 was be VBD cord-005453-4057qib7 9799 15 73,3 73,3 CD cord-005453-4057qib7 9799 16 % % NN cord-005453-4057qib7 9799 17 . . . cord-005453-4057qib7 9800 1 Development development NN cord-005453-4057qib7 9800 2 of of IN cord-005453-4057qib7 9800 3 IFD IFD NNP cord-005453-4057qib7 9800 4 after after IN cord-005453-4057qib7 9800 5 allo allo NN cord-005453-4057qib7 9800 6 - - HYPH cord-005453-4057qib7 9800 7 HSCT HSCT NNP cord-005453-4057qib7 9800 8 do do VBP cord-005453-4057qib7 9800 9 not not RB cord-005453-4057qib7 9800 10 decrease decrease VB cord-005453-4057qib7 9800 11 the the DT cord-005453-4057qib7 9800 12 2-year 2-year CD cord-005453-4057qib7 9800 13 OS os NN cord-005453-4057qib7 9800 14 rate rate NN cord-005453-4057qib7 9800 15 ( ( -LRB- cord-005453-4057qib7 9800 16 69,2 69,2 CD cord-005453-4057qib7 9800 17 % % NN cord-005453-4057qib7 9800 18 vs vs IN cord-005453-4057qib7 9800 19 74 74 CD cord-005453-4057qib7 9800 20 % % NN cord-005453-4057qib7 9800 21 , , , cord-005453-4057qib7 9800 22 p=0,77 p=0,77 ADD cord-005453-4057qib7 9800 23 ) ) -RRB- cord-005453-4057qib7 9800 24 . . . cord-005453-4057qib7 9801 1 The the DT cord-005453-4057qib7 9801 2 impact impact NN cord-005453-4057qib7 9801 3 of of IN cord-005453-4057qib7 9801 4 prior prior JJ cord-005453-4057qib7 9801 5 IFD IFD NNP cord-005453-4057qib7 9801 6 on on IN cord-005453-4057qib7 9801 7 2-year 2-year CD cord-005453-4057qib7 9801 8 OS os NN cord-005453-4057qib7 9801 9 in in IN cord-005453-4057qib7 9801 10 allo allo NN cord-005453-4057qib7 9801 11 - - HYPH cord-005453-4057qib7 9801 12 HSCT HSCT NNP cord-005453-4057qib7 9801 13 recipients recipient NNS cord-005453-4057qib7 9801 14 was be VBD cord-005453-4057qib7 9801 15 not not RB cord-005453-4057qib7 9801 16 statistically statistically RB cord-005453-4057qib7 9801 17 significant significant JJ cord-005453-4057qib7 9801 18 in in IN cord-005453-4057qib7 9801 19 all all DT cord-005453-4057qib7 9801 20 group group NN cord-005453-4057qib7 9801 21 ( ( -LRB- cord-005453-4057qib7 9801 22 63,6 63,6 CD cord-005453-4057qib7 9801 23 % % NN cord-005453-4057qib7 9801 24 vs vs IN cord-005453-4057qib7 9801 25 74,7 74,7 CD cord-005453-4057qib7 9801 26 % % NN cord-005453-4057qib7 9801 27 , , , cord-005453-4057qib7 9801 28 p=0,47 p=0,47 NNP cord-005453-4057qib7 9801 29 ) ) -RRB- cord-005453-4057qib7 9801 30 , , , cord-005453-4057qib7 9801 31 and and CC cord-005453-4057qib7 9801 32 separately separately RB cord-005453-4057qib7 9801 33 in in IN cord-005453-4057qib7 9801 34 children child NNS cord-005453-4057qib7 9801 35 and and CC cord-005453-4057qib7 9801 36 adults adult NNS cord-005453-4057qib7 9801 37 . . . cord-005453-4057qib7 9802 1 Conclusions conclusion NNS cord-005453-4057qib7 9802 2 : : : cord-005453-4057qib7 9803 1 Incidence incidence NN cord-005453-4057qib7 9803 2 of of IN cord-005453-4057qib7 9803 3 IFD IFD NNP cord-005453-4057qib7 9803 4 in in IN cord-005453-4057qib7 9803 5 children child NNS cord-005453-4057qib7 9803 6 and and CC cord-005453-4057qib7 9803 7 adults adult NNS cord-005453-4057qib7 9803 8 with with IN cord-005453-4057qib7 9803 9 Hodgkin Hodgkin NNP cord-005453-4057qib7 9803 10 's 's POS cord-005453-4057qib7 9803 11 lymphoma lymphoma NN cord-005453-4057qib7 9803 12 before before IN cord-005453-4057qib7 9803 13 allo allo NN cord-005453-4057qib7 9803 14 - - HYPH cord-005453-4057qib7 9803 15 HSCT HSCT NNP cord-005453-4057qib7 9803 16 was be VBD cord-005453-4057qib7 9803 17 12,8 12,8 CD cord-005453-4057qib7 9803 18 % % NN cord-005453-4057qib7 9803 19 . . . cord-005453-4057qib7 9804 1 Incidence incidence NN cord-005453-4057qib7 9804 2 of of IN cord-005453-4057qib7 9804 3 IFD IFD NNP cord-005453-4057qib7 9804 4 after after IN cord-005453-4057qib7 9804 5 allo allo NN cord-005453-4057qib7 9804 6 - - HYPH cord-005453-4057qib7 9804 7 HSCT HSCT NNP cord-005453-4057qib7 9804 8 in in IN cord-005453-4057qib7 9804 9 patients patient NNS cord-005453-4057qib7 9804 10 with with IN cord-005453-4057qib7 9804 11 Hodgkin Hodgkin NNP cord-005453-4057qib7 9804 12 's 's POS cord-005453-4057qib7 9804 13 lymphoma lymphoma NN cord-005453-4057qib7 9804 14 was be VBD cord-005453-4057qib7 9804 15 17,6 17,6 CD cord-005453-4057qib7 9804 16 % % NN cord-005453-4057qib7 9804 17 . . . cord-005453-4057qib7 9805 1 The the DT cord-005453-4057qib7 9805 2 major major JJ cord-005453-4057qib7 9805 3 etiology etiology NN cord-005453-4057qib7 9805 4 agents agent NNS cord-005453-4057qib7 9805 5 as as IN cord-005453-4057qib7 9805 6 before before IN cord-005453-4057qib7 9805 7 as as IN cord-005453-4057qib7 9805 8 after after IN cord-005453-4057qib7 9805 9 allo allo NN cord-005453-4057qib7 9805 10 - - HYPH cord-005453-4057qib7 9805 11 HSCT HSCT NNP cord-005453-4057qib7 9805 12 were be VBD cord-005453-4057qib7 9805 13 Aspergillus aspergillus NN cord-005453-4057qib7 9805 14 spp spp NNS cord-005453-4057qib7 9805 15 . . . cord-005453-4057qib7 9806 1 IFD IFD NNP cord-005453-4057qib7 9806 2 was be VBD cord-005453-4057qib7 9806 3 a a DT cord-005453-4057qib7 9806 4 late late JJ cord-005453-4057qib7 9806 5 complication complication NN cord-005453-4057qib7 9806 6 after after IN cord-005453-4057qib7 9806 7 allo allo NN cord-005453-4057qib7 9806 8 - - HYPH cord-005453-4057qib7 9806 9 HSCT HSCT NNP cord-005453-4057qib7 9806 10 and and CC cord-005453-4057qib7 9806 11 associated associate VBN cord-005453-4057qib7 9806 12 with with IN cord-005453-4057qib7 9806 13 post post JJ cord-005453-4057qib7 9806 14 - - JJ cord-005453-4057qib7 9806 15 HSCT hsct JJ cord-005453-4057qib7 9806 16 relapse relapse NN cord-005453-4057qib7 9806 17 . . . cord-005453-4057qib7 9807 1 Despite despite IN cord-005453-4057qib7 9807 2 the the DT cord-005453-4057qib7 9807 3 high high JJ cord-005453-4057qib7 9807 4 incidence incidence NN cord-005453-4057qib7 9807 5 IFD IFD NNP cord-005453-4057qib7 9807 6 before before IN cord-005453-4057qib7 9807 7 or or CC cord-005453-4057qib7 9807 8 after after IN cord-005453-4057qib7 9807 9 allo allo NN cord-005453-4057qib7 9807 10 - - HYPH cord-005453-4057qib7 9807 11 HSCT HSCT NNP cord-005453-4057qib7 9807 12 did do VBD cord-005453-4057qib7 9807 13 n't not RB cord-005453-4057qib7 9807 14 influence influence VB cord-005453-4057qib7 9807 15 the the DT cord-005453-4057qib7 9807 16 outcome outcome NN cord-005453-4057qib7 9807 17 in in IN cord-005453-4057qib7 9807 18 children child NNS cord-005453-4057qib7 9807 19 and and CC cord-005453-4057qib7 9807 20 adults adult NNS cord-005453-4057qib7 9807 21 with with IN cord-005453-4057qib7 9807 22 Hodgkin Hodgkin NNP cord-005453-4057qib7 9807 23 lymphoma lymphoma NN cord-005453-4057qib7 9807 24 . . . cord-005453-4057qib7 9808 1 Disclosure disclosure NN cord-005453-4057qib7 9808 2 : : : cord-005453-4057qib7 9808 3 Nothing nothing NN cord-005453-4057qib7 9808 4 to to TO cord-005453-4057qib7 9808 5 declare declare VB cord-005453-4057qib7 9808 6 Our -PRON- PRP$ cord-005453-4057qib7 9808 7 community community NN cord-005453-4057qib7 9808 8 has have VBZ cord-005453-4057qib7 9808 9 high high JJ cord-005453-4057qib7 9808 10 CMV CMV NNP cord-005453-4057qib7 9808 11 positive positive JJ cord-005453-4057qib7 9808 12 serostatus serostatus NN cord-005453-4057qib7 9808 13 , , , cord-005453-4057qib7 9808 14 which which WDT cord-005453-4057qib7 9808 15 is be VBZ cord-005453-4057qib7 9808 16 a a DT cord-005453-4057qib7 9808 17 known known JJ cord-005453-4057qib7 9808 18 risk risk NN cord-005453-4057qib7 9808 19 for for IN cord-005453-4057qib7 9808 20 CMV CMV NNP cord-005453-4057qib7 9808 21 infection infection NN cord-005453-4057qib7 9808 22 or or CC cord-005453-4057qib7 9808 23 reactivation reactivation NN cord-005453-4057qib7 9808 24 . . . cord-005453-4057qib7 9809 1 We -PRON- PRP cord-005453-4057qib7 9809 2 conducted conduct VBD cord-005453-4057qib7 9809 3 a a DT cord-005453-4057qib7 9809 4 study study NN cord-005453-4057qib7 9809 5 to to TO cord-005453-4057qib7 9809 6 explore explore VB cord-005453-4057qib7 9809 7 the the DT cord-005453-4057qib7 9809 8 incidence incidence NN cord-005453-4057qib7 9809 9 and and CC cord-005453-4057qib7 9809 10 outcome outcome NN cord-005453-4057qib7 9809 11 of of IN cord-005453-4057qib7 9809 12 CMV CMV NNP cord-005453-4057qib7 9809 13 infection infection NN cord-005453-4057qib7 9809 14 among among IN cord-005453-4057qib7 9809 15 post post JJ cord-005453-4057qib7 9809 16 - - JJ cord-005453-4057qib7 9809 17 HSCT hsct JJ cord-005453-4057qib7 9809 18 children child NNS cord-005453-4057qib7 9809 19 . . . cord-005453-4057qib7 9810 1 Methods method NNS cord-005453-4057qib7 9810 2 : : : cord-005453-4057qib7 9810 3 Medical Medical NNP cord-005453-4057qib7 9810 4 Records Records NNPS cord-005453-4057qib7 9810 5 of of IN cord-005453-4057qib7 9810 6 pediatric pediatric JJ cord-005453-4057qib7 9810 7 patients patient NNS cord-005453-4057qib7 9810 8 ( ( -LRB- cord-005453-4057qib7 9810 9 Age age NN cord-005453-4057qib7 9810 10 ≤ ≤ NN cord-005453-4057qib7 9810 11 14 14 CD cord-005453-4057qib7 9810 12 years year NNS cord-005453-4057qib7 9810 13 ) ) -RRB- cord-005453-4057qib7 9810 14 undergoing undergo VBG cord-005453-4057qib7 9810 15 single single JJ cord-005453-4057qib7 9810 16 allogeneic allogeneic NN cord-005453-4057qib7 9810 17 HSCT HSCT NNP cord-005453-4057qib7 9810 18 from from IN cord-005453-4057qib7 9810 19 January January NNP cord-005453-4057qib7 9810 20 2014 2014 CD cord-005453-4057qib7 9810 21 to to IN cord-005453-4057qib7 9810 22 December December NNP cord-005453-4057qib7 9810 23 2016 2016 CD cord-005453-4057qib7 9810 24 , , , cord-005453-4057qib7 9810 25 at at IN cord-005453-4057qib7 9810 26 King King NNP cord-005453-4057qib7 9810 27 Faisal Faisal NNP cord-005453-4057qib7 9810 28 Specialist Specialist NNP cord-005453-4057qib7 9810 29 Hospital Hospital NNP cord-005453-4057qib7 9810 30 and and CC cord-005453-4057qib7 9810 31 Research Research NNP cord-005453-4057qib7 9810 32 Centre Centre NNP cord-005453-4057qib7 9810 33 , , , cord-005453-4057qib7 9810 34 Riyadh Riyadh NNP cord-005453-4057qib7 9810 35 , , , cord-005453-4057qib7 9810 36 Saudi Saudi NNP cord-005453-4057qib7 9810 37 Arabia Arabia NNP cord-005453-4057qib7 9810 38 , , , cord-005453-4057qib7 9810 39 were be VBD cord-005453-4057qib7 9810 40 reviewed review VBN cord-005453-4057qib7 9810 41 . . . cord-005453-4057qib7 9811 1 All all DT cord-005453-4057qib7 9811 2 patients patient NNS cord-005453-4057qib7 9811 3 with with IN cord-005453-4057qib7 9811 4 active active JJ cord-005453-4057qib7 9811 5 CMV CMV NNP cord-005453-4057qib7 9811 6 infection infection NN cord-005453-4057qib7 9811 7 or or CC cord-005453-4057qib7 9811 8 disease disease NN cord-005453-4057qib7 9811 9 before before RB cord-005453-4057qib7 9811 10 and and CC cord-005453-4057qib7 9811 11 during during IN cord-005453-4057qib7 9811 12 transplant transplant NN cord-005453-4057qib7 9811 13 were be VBD cord-005453-4057qib7 9811 14 excluded exclude VBN cord-005453-4057qib7 9811 15 . . . cord-005453-4057qib7 9812 1 A a DT cord-005453-4057qib7 9812 2 total total NN cord-005453-4057qib7 9812 3 of of IN cord-005453-4057qib7 9812 4 307 307 CD cord-005453-4057qib7 9812 5 patients patient NNS cord-005453-4057qib7 9812 6 were be VBD cord-005453-4057qib7 9812 7 included include VBN cord-005453-4057qib7 9812 8 in in IN cord-005453-4057qib7 9812 9 the the DT cord-005453-4057qib7 9812 10 study study NN cord-005453-4057qib7 9812 11 ; ; : cord-005453-4057qib7 9812 12 160 160 CD cord-005453-4057qib7 9812 13 were be VBD cord-005453-4057qib7 9812 14 female female JJ cord-005453-4057qib7 9812 15 . . . cord-005453-4057qib7 9813 1 Median median JJ cord-005453-4057qib7 9813 2 age age NN cord-005453-4057qib7 9813 3 at at IN cord-005453-4057qib7 9813 4 HSCT HSCT NNP cord-005453-4057qib7 9813 5 was be VBD cord-005453-4057qib7 9813 6 5 5 CD cord-005453-4057qib7 9813 7 years year NNS cord-005453-4057qib7 9813 8 . . . cord-005453-4057qib7 9814 1 Recipient recipient NN cord-005453-4057qib7 9814 2 CMV CMV NNP cord-005453-4057qib7 9814 3 serostatus serostatus NN cord-005453-4057qib7 9814 4 was be VBD cord-005453-4057qib7 9814 5 positive positive JJ cord-005453-4057qib7 9814 6 in in IN cord-005453-4057qib7 9814 7 213 213 CD cord-005453-4057qib7 9814 8 patients patient NNS cord-005453-4057qib7 9814 9 before before IN cord-005453-4057qib7 9814 10 HSCT HSCT NNP cord-005453-4057qib7 9814 11 , , , cord-005453-4057qib7 9814 12 and and CC cord-005453-4057qib7 9814 13 232 232 CD cord-005453-4057qib7 9814 14 donors donor NNS cord-005453-4057qib7 9814 15 were be VBD cord-005453-4057qib7 9814 16 CMVpositive CMVpositive NNP cord-005453-4057qib7 9814 17 . . . cord-005453-4057qib7 9815 1 The the DT cord-005453-4057qib7 9815 2 Recipient Recipient NNP cord-005453-4057qib7 9815 3 - - HYPH cord-005453-4057qib7 9815 4 donor donor NN cord-005453-4057qib7 9815 5 ( ( -LRB- cord-005453-4057qib7 9815 6 R r NN cord-005453-4057qib7 9815 7 / / SYM cord-005453-4057qib7 9815 8 D d NN cord-005453-4057qib7 9815 9 ) ) -RRB- cord-005453-4057qib7 9815 10 serology serology NN cord-005453-4057qib7 9815 11 was be VBD cord-005453-4057qib7 9815 12 63.7 63.7 CD cord-005453-4057qib7 9815 13 % % NN cord-005453-4057qib7 9815 14 R r NN cord-005453-4057qib7 9815 15 + + CC cord-005453-4057qib7 9815 16 /D+ /D+ NNP cord-005453-4057qib7 9815 17 , , , cord-005453-4057qib7 9815 18 15.3 15.3 CD cord-005453-4057qib7 9815 19 % % NN cord-005453-4057qib7 9815 20 R+/D- R+/D- NNP cord-005453-4057qib7 9815 21 , , , cord-005453-4057qib7 9815 22 13.7 13.7 CD cord-005453-4057qib7 9815 23 % % NN cord-005453-4057qib7 9815 24 R-/D+ r-/d+ NN cord-005453-4057qib7 9815 25 , , , cord-005453-4057qib7 9815 26 and and CC cord-005453-4057qib7 9815 27 7.3 7.3 CD cord-005453-4057qib7 9815 28 % % NN cord-005453-4057qib7 9815 29 R-/D- R-/D- NNPS cord-005453-4057qib7 9815 30 . . . cord-005453-4057qib7 9816 1 Indication indication NN cord-005453-4057qib7 9816 2 for for IN cord-005453-4057qib7 9816 3 HSCT HSCT NNP cord-005453-4057qib7 9816 4 was be VBD cord-005453-4057qib7 9816 5 Immune Immune NNP cord-005453-4057qib7 9816 6 Disorders Disorders NNPS cord-005453-4057qib7 9816 7 24.1 24.1 CD cord-005453-4057qib7 9816 8 % % NN cord-005453-4057qib7 9816 9 , , , cord-005453-4057qib7 9817 1 Hemoglobinopathies Hemoglobinopathies NNP cord-005453-4057qib7 9817 2 20.8 20.8 CD cord-005453-4057qib7 9817 3 % % NN cord-005453-4057qib7 9817 4 , , , cord-005453-4057qib7 9817 5 Bone Bone NNP cord-005453-4057qib7 9817 6 Marrow Marrow NNP cord-005453-4057qib7 9817 7 Failure Failure NNP cord-005453-4057qib7 9817 8 20.5 20.5 CD cord-005453-4057qib7 9817 9 % % NN cord-005453-4057qib7 9817 10 , , , cord-005453-4057qib7 9817 11 Malignant malignant JJ cord-005453-4057qib7 9817 12 Disorders Disorders NNPS cord-005453-4057qib7 9817 13 20.5 20.5 CD cord-005453-4057qib7 9817 14 % % NN cord-005453-4057qib7 9817 15 , , , cord-005453-4057qib7 9817 16 Histiocytic Histiocytic NNP cord-005453-4057qib7 9817 17 8.1 8.1 CD cord-005453-4057qib7 9817 18 % % NN cord-005453-4057qib7 9817 19 , , , cord-005453-4057qib7 9817 20 and and CC cord-005453-4057qib7 9817 21 Metabolic metabolic JJ cord-005453-4057qib7 9817 22 Disorders disorder NNS cord-005453-4057qib7 9817 23 5.9 5.9 CD cord-005453-4057qib7 9817 24 % % NN cord-005453-4057qib7 9817 25 . . . cord-005453-4057qib7 9818 1 Source source NN cord-005453-4057qib7 9818 2 of of IN cord-005453-4057qib7 9818 3 stem stem NN cord-005453-4057qib7 9818 4 cells cell NNS cord-005453-4057qib7 9818 5 was be VBD cord-005453-4057qib7 9818 6 Bone Bone NNP cord-005453-4057qib7 9818 7 marrow marrow NN cord-005453-4057qib7 9818 8 in in IN cord-005453-4057qib7 9818 9 223 223 CD cord-005453-4057qib7 9819 1 , , , cord-005453-4057qib7 9819 2 Cord cord NN cord-005453-4057qib7 9819 3 blood blood NN cord-005453-4057qib7 9819 4 in in IN cord-005453-4057qib7 9819 5 74 74 CD cord-005453-4057qib7 9819 6 and and CC cord-005453-4057qib7 9819 7 Peripheral Peripheral NNP cord-005453-4057qib7 9819 8 Blood Blood NNP cord-005453-4057qib7 9819 9 Stem Stem NNP cord-005453-4057qib7 9819 10 Cell cell NN cord-005453-4057qib7 9819 11 in in IN cord-005453-4057qib7 9819 12 10 10 CD cord-005453-4057qib7 9819 13 cases case NNS cord-005453-4057qib7 9819 14 . . . cord-005453-4057qib7 9820 1 Donor donor NN cord-005453-4057qib7 9820 2 was be VBD cord-005453-4057qib7 9820 3 matched match VBN cord-005453-4057qib7 9820 4 related relate VBN cord-005453-4057qib7 9820 5 among among IN cord-005453-4057qib7 9820 6 198 198 CD cord-005453-4057qib7 9820 7 , , , cord-005453-4057qib7 9820 8 Unrelated unrelated JJ cord-005453-4057qib7 9820 9 matched match VBD cord-005453-4057qib7 9820 10 / / SYM cord-005453-4057qib7 9820 11 mismatched mismatch VBN cord-005453-4057qib7 9820 12 in in IN cord-005453-4057qib7 9820 13 74 74 CD cord-005453-4057qib7 9820 14 , , , cord-005453-4057qib7 9820 15 haploidentical haploidentical JJ cord-005453-4057qib7 9820 16 24 24 CD cord-005453-4057qib7 9820 17 , , , cord-005453-4057qib7 9820 18 and and CC cord-005453-4057qib7 9820 19 Related relate VBN cord-005453-4057qib7 9820 20 with with IN cord-005453-4057qib7 9820 21 1-Antigen 1-antigen CD cord-005453-4057qib7 9820 22 mismatch mismatch NN cord-005453-4057qib7 9820 23 in in IN cord-005453-4057qib7 9820 24 11 11 CD cord-005453-4057qib7 9820 25 . . . cord-005453-4057qib7 9821 1 Total total JJ cord-005453-4057qib7 9821 2 body body NN cord-005453-4057qib7 9821 3 irradiation irradiation NN cord-005453-4057qib7 9821 4 ( ( -LRB- cord-005453-4057qib7 9821 5 TBI TBI NNP cord-005453-4057qib7 9821 6 ) ) -RRB- cord-005453-4057qib7 9821 7 based base VBN cord-005453-4057qib7 9821 8 conditioning conditioning NN cord-005453-4057qib7 9821 9 was be VBD cord-005453-4057qib7 9821 10 used use VBN cord-005453-4057qib7 9821 11 for for IN cord-005453-4057qib7 9821 12 47 47 CD cord-005453-4057qib7 9821 13 patients patient NNS cord-005453-4057qib7 9821 14 , , , cord-005453-4057qib7 9821 15 while while IN cord-005453-4057qib7 9821 16 ATG ATG NNP cord-005453-4057qib7 9821 17 was be VBD cord-005453-4057qib7 9821 18 used use VBN cord-005453-4057qib7 9821 19 in in IN cord-005453-4057qib7 9821 20 169 169 CD cord-005453-4057qib7 9821 21 patients patient NNS cord-005453-4057qib7 9821 22 . . . cord-005453-4057qib7 9822 1 Results result NNS cord-005453-4057qib7 9822 2 : : : cord-005453-4057qib7 9823 1 Out out IN cord-005453-4057qib7 9823 2 of of IN cord-005453-4057qib7 9823 3 a a DT cord-005453-4057qib7 9823 4 total total NN cord-005453-4057qib7 9823 5 of of IN cord-005453-4057qib7 9823 6 307 307 CD cord-005453-4057qib7 9823 7 patients patient NNS cord-005453-4057qib7 9823 8 , , , cord-005453-4057qib7 9823 9 101 101 CD cord-005453-4057qib7 9823 10 patients patient NNS cord-005453-4057qib7 9823 11 developed develop VBD cord-005453-4057qib7 9823 12 CMV CMV NNP cord-005453-4057qib7 9823 13 infection infection NN cord-005453-4057qib7 9823 14 post post JJ cord-005453-4057qib7 9823 15 - - JJ cord-005453-4057qib7 9823 16 HSCT HSCT NNP cord-005453-4057qib7 9823 17 ( ( -LRB- cord-005453-4057qib7 9823 18 32.9 32.9 CD cord-005453-4057qib7 9823 19 % % NN cord-005453-4057qib7 9823 20 ) ) -RRB- cord-005453-4057qib7 9823 21 . . . cord-005453-4057qib7 9824 1 Incidence incidence NN cord-005453-4057qib7 9824 2 in in IN cord-005453-4057qib7 9824 3 female female JJ cord-005453-4057qib7 9824 4 recipients recipient NNS cord-005453-4057qib7 9824 5 was be VBD cord-005453-4057qib7 9824 6 high high JJ cord-005453-4057qib7 9824 7 ( ( -LRB- cord-005453-4057qib7 9824 8 38.1 38.1 CD cord-005453-4057qib7 9824 9 % % NN cord-005453-4057qib7 9824 10 versus versus IN cord-005453-4057qib7 9824 11 27.2 27.2 CD cord-005453-4057qib7 9824 12 % % NN cord-005453-4057qib7 9824 13 , , , cord-005453-4057qib7 9824 14 p p NN cord-005453-4057qib7 9824 15 - - HYPH cord-005453-4057qib7 9824 16 value value NN cord-005453-4057qib7 9824 17 0.042 0.042 CD cord-005453-4057qib7 9824 18 ) ) -RRB- cord-005453-4057qib7 9824 19 . . . cord-005453-4057qib7 9825 1 Both both DT cord-005453-4057qib7 9825 2 recipient recipient NN cord-005453-4057qib7 9825 3 and and CC cord-005453-4057qib7 9825 4 donor donor NN cord-005453-4057qib7 9825 5 CMV CMV NNP cord-005453-4057qib7 9825 6 serology serology NN cord-005453-4057qib7 9825 7 positive positive JJ cord-005453-4057qib7 9825 8 ( ( -LRB- cord-005453-4057qib7 9825 9 42.5 42.5 CD cord-005453-4057qib7 9825 10 % % NN cord-005453-4057qib7 9825 11 ) ) -RRB- cord-005453-4057qib7 9825 12 developed develop VBD cord-005453-4057qib7 9825 13 CMV CMV NNP cord-005453-4057qib7 9825 14 infection infection NN cord-005453-4057qib7 9826 1 ( ( -LRB- cord-005453-4057qib7 9826 2 p p NN cord-005453-4057qib7 9826 3 - - HYPH cord-005453-4057qib7 9826 4 value value NN cord-005453-4057qib7 9826 5 < < XX cord-005453-4057qib7 9826 6 0.001 0.001 CD cord-005453-4057qib7 9826 7 ) ) -RRB- cord-005453-4057qib7 9826 8 . . . cord-005453-4057qib7 9827 1 However however RB cord-005453-4057qib7 9827 2 , , , cord-005453-4057qib7 9827 3 no no DT cord-005453-4057qib7 9827 4 CMV CMV NNP cord-005453-4057qib7 9827 5 infection infection NN cord-005453-4057qib7 9827 6 in in IN cord-005453-4057qib7 9827 7 both both DT cord-005453-4057qib7 9827 8 recipient recipient NN cord-005453-4057qib7 9827 9 and and CC cord-005453-4057qib7 9827 10 donor donor NN cord-005453-4057qib7 9827 11 negative negative JJ cord-005453-4057qib7 9827 12 group group NN cord-005453-4057qib7 9827 13 ( ( -LRB- cord-005453-4057qib7 9827 14 R-/D- R-/D- NNP cord-005453-4057qib7 9827 15 ) ) -RRB- cord-005453-4057qib7 9827 16 . . . cord-005453-4057qib7 9828 1 The the DT cord-005453-4057qib7 9828 2 incidence incidence NN cord-005453-4057qib7 9828 3 of of IN cord-005453-4057qib7 9828 4 CMV CMV NNP cord-005453-4057qib7 9828 5 infection infection NN cord-005453-4057qib7 9828 6 post post NN cord-005453-4057qib7 9828 7 - - JJ cord-005453-4057qib7 9828 8 HSCT HSCT NNP cord-005453-4057qib7 9828 9 was be VBD cord-005453-4057qib7 9828 10 high high JJ cord-005453-4057qib7 9828 11 in in IN cord-005453-4057qib7 9828 12 patients patient NNS cord-005453-4057qib7 9828 13 received receive VBD cord-005453-4057qib7 9828 14 TBI TBI NNP cord-005453-4057qib7 9828 15 based base VBN cord-005453-4057qib7 9828 16 conditioning conditioning NN cord-005453-4057qib7 9828 17 ( ( -LRB- cord-005453-4057qib7 9828 18 22 22 CD cord-005453-4057qib7 9828 19 out out IN cord-005453-4057qib7 9828 20 of of IN cord-005453-4057qib7 9828 21 47 47 CD cord-005453-4057qib7 9828 22 , , , cord-005453-4057qib7 9828 23 46 46 CD cord-005453-4057qib7 9828 24 .8 .8 CD cord-005453-4057qib7 9828 25 % % NN cord-005453-4057qib7 9828 26 , , , cord-005453-4057qib7 9828 27 p p NN cord-005453-4057qib7 9828 28 - - HYPH cord-005453-4057qib7 9828 29 value value NN cord-005453-4057qib7 9828 30 0.027 0.027 CD cord-005453-4057qib7 9828 31 ) ) -RRB- cord-005453-4057qib7 9828 32 , , , cord-005453-4057qib7 9828 33 and and CC cord-005453-4057qib7 9828 34 in in IN cord-005453-4057qib7 9828 35 haploidentical haploidentical JJ cord-005453-4057qib7 9828 36 transplant transplant NN cord-005453-4057qib7 9828 37 with with IN cord-005453-4057qib7 9828 38 66.7 66.7 CD cord-005453-4057qib7 9828 39 % % NN cord-005453-4057qib7 9828 40 ( ( -LRB- cord-005453-4057qib7 9828 41 p p NN cord-005453-4057qib7 9828 42 - - HYPH cord-005453-4057qib7 9828 43 value value NN cord-005453-4057qib7 9828 44 0.008 0.008 CD cord-005453-4057qib7 9828 45 ) ) -RRB- cord-005453-4057qib7 9828 46 . . . cord-005453-4057qib7 9829 1 Source source NN cord-005453-4057qib7 9829 2 of of IN cord-005453-4057qib7 9829 3 stem stem NN cord-005453-4057qib7 9829 4 cells cell NNS cord-005453-4057qib7 9829 5 , , , cord-005453-4057qib7 9829 6 myeloablative myeloablative NNP cord-005453-4057qib7 9829 7 versus versus IN cord-005453-4057qib7 9829 8 nonmyeloablative nonmyeloablative JJ cord-005453-4057qib7 9829 9 conditioning conditioning NN cord-005453-4057qib7 9829 10 , , , cord-005453-4057qib7 9829 11 ATG ATG NNP cord-005453-4057qib7 9829 12 use use NN cord-005453-4057qib7 9829 13 in in IN cord-005453-4057qib7 9829 14 conditioning conditioning NN cord-005453-4057qib7 9829 15 and and CC cord-005453-4057qib7 9829 16 aGVHD aGVHD NNP cord-005453-4057qib7 9829 17 , , , cord-005453-4057qib7 9829 18 did do VBD cord-005453-4057qib7 9829 19 not not RB cord-005453-4057qib7 9829 20 exhibit exhibit VB cord-005453-4057qib7 9829 21 significant significant JJ cord-005453-4057qib7 9829 22 association association NN cord-005453-4057qib7 9829 23 with with IN cord-005453-4057qib7 9829 24 CMV CMV NNP cord-005453-4057qib7 9829 25 infection infection NN cord-005453-4057qib7 9829 26 . . . cord-005453-4057qib7 9830 1 In in IN cord-005453-4057qib7 9830 2 multivariable multivariable JJ cord-005453-4057qib7 9830 3 setting setting NN cord-005453-4057qib7 9830 4 , , , cord-005453-4057qib7 9830 5 when when WRB cord-005453-4057qib7 9830 6 adjusted adjust VBN cord-005453-4057qib7 9830 7 for for IN cord-005453-4057qib7 9830 8 primary primary JJ cord-005453-4057qib7 9830 9 indication indication NN cord-005453-4057qib7 9830 10 for for IN cord-005453-4057qib7 9830 11 transplant transplant NN cord-005453-4057qib7 9830 12 , , , cord-005453-4057qib7 9830 13 Donor Donor NNP cord-005453-4057qib7 9830 14 HLA HLA NNP cord-005453-4057qib7 9830 15 Type Type NNP cord-005453-4057qib7 9830 16 , , , cord-005453-4057qib7 9830 17 TBI TBI NNP cord-005453-4057qib7 9830 18 based base VBN cord-005453-4057qib7 9830 19 conditioning conditioning NN cord-005453-4057qib7 9830 20 and and CC cord-005453-4057qib7 9830 21 Recipient Recipient NNP cord-005453-4057qib7 9830 22 and and CC cord-005453-4057qib7 9830 23 Donor Donor NNP cord-005453-4057qib7 9830 24 CMV CMV NNP cord-005453-4057qib7 9830 25 Serology Serology NNP cord-005453-4057qib7 9830 26 at at IN cord-005453-4057qib7 9830 27 transplant transplant NN cord-005453-4057qib7 9830 28 , , , cord-005453-4057qib7 9830 29 haploidentical haploidentical JJ cord-005453-4057qib7 9830 30 donor donor NN cord-005453-4057qib7 9830 31 ( ( -LRB- cord-005453-4057qib7 9830 32 Odds Odds NNPS cord-005453-4057qib7 9830 33 ratio ratio NN cord-005453-4057qib7 9830 34 : : : cord-005453-4057qib7 9830 35 3.491 3.491 CD cord-005453-4057qib7 9830 36 , , , cord-005453-4057qib7 9830 37 P P NNP cord-005453-4057qib7 9830 38 - - HYPH cord-005453-4057qib7 9830 39 Value value NN cord-005453-4057qib7 9830 40 : : : cord-005453-4057qib7 9830 41 0.041 0.041 CD cord-005453-4057qib7 9830 42 ) ) -RRB- cord-005453-4057qib7 9830 43 and and CC cord-005453-4057qib7 9830 44 Donor Donor NNP cord-005453-4057qib7 9830 45 - - HYPH cord-005453-4057qib7 9830 46 Recipient Recipient NNP cord-005453-4057qib7 9830 47 CMV CMV NNP cord-005453-4057qib7 9830 48 sero sero NN cord-005453-4057qib7 9830 49 - - HYPH cord-005453-4057qib7 9830 50 positivity positivity NN cord-005453-4057qib7 9830 51 ( ( -LRB- cord-005453-4057qib7 9830 52 Odds odd NNS cord-005453-4057qib7 9830 53 ratio ratio NN cord-005453-4057qib7 9830 54 : : : cord-005453-4057qib7 9830 55 2.228 2.228 CD cord-005453-4057qib7 9830 56 , , , cord-005453-4057qib7 9830 57 P p NN cord-005453-4057qib7 9830 58 - - HYPH cord-005453-4057qib7 9830 59 Value value NN cord-005453-4057qib7 9830 60 : : : cord-005453-4057qib7 9830 61 0.007 0.007 CD cord-005453-4057qib7 9830 62 ) ) -RRB- cord-005453-4057qib7 9830 63 were be VBD cord-005453-4057qib7 9830 64 found find VBN cord-005453-4057qib7 9830 65 to to TO cord-005453-4057qib7 9830 66 be be VB cord-005453-4057qib7 9830 67 significant significant JJ cord-005453-4057qib7 9830 68 risk risk NN cord-005453-4057qib7 9830 69 factors factor NNS cord-005453-4057qib7 9830 70 . . . cord-005453-4057qib7 9831 1 CMV CMV NNP cord-005453-4057qib7 9831 2 infection infection NN cord-005453-4057qib7 9831 3 resolution resolution NN cord-005453-4057qib7 9831 4 rate rate NN cord-005453-4057qib7 9831 5 was be VBD cord-005453-4057qib7 9831 6 83.2 83.2 CD cord-005453-4057qib7 9831 7 % % NN cord-005453-4057qib7 9831 8 ( ( -LRB- cord-005453-4057qib7 9831 9 84 84 CD cord-005453-4057qib7 9831 10 ) ) -RRB- cord-005453-4057qib7 9831 11 . . . cord-005453-4057qib7 9832 1 With with IN cord-005453-4057qib7 9832 2 a a DT cord-005453-4057qib7 9832 3 median median JJ cord-005453-4057qib7 9832 4 follow follow NN cord-005453-4057qib7 9832 5 - - HYPH cord-005453-4057qib7 9832 6 up up NN cord-005453-4057qib7 9832 7 time time NN cord-005453-4057qib7 9832 8 of of IN cord-005453-4057qib7 9832 9 32.9 32.9 CD cord-005453-4057qib7 9832 10 ±1.5 ±1.5 VBG cord-005453-4057qib7 9832 11 months month NNS cord-005453-4057qib7 9832 12 from from IN cord-005453-4057qib7 9832 13 infusion infusion NN cord-005453-4057qib7 9832 14 , , , cord-005453-4057qib7 9832 15 five five CD cord-005453-4057qib7 9832 16 - - HYPH cord-005453-4057qib7 9832 17 year year NN cord-005453-4057qib7 9832 18 overall overall JJ cord-005453-4057qib7 9832 19 survival survival NN cord-005453-4057qib7 9832 20 of of IN cord-005453-4057qib7 9832 21 CMV CMV NNP cord-005453-4057qib7 9832 22 infected infected JJ cord-005453-4057qib7 9832 23 group group NN cord-005453-4057qib7 9832 24 was be VBD cord-005453-4057qib7 9832 25 lower low JJR cord-005453-4057qib7 9832 26 ( ( -LRB- cord-005453-4057qib7 9832 27 0.658±0.087 0.658±0.087 CD cord-005453-4057qib7 9832 28 ) ) -RRB- cord-005453-4057qib7 9832 29 as as IN cord-005453-4057qib7 9832 30 compared compare VBN cord-005453-4057qib7 9832 31 to to IN cord-005453-4057qib7 9832 32 non non JJ cord-005453-4057qib7 9832 33 - - JJ cord-005453-4057qib7 9832 34 CMV CMV NNP cord-005453-4057qib7 9832 35 infected infect VBN cord-005453-4057qib7 9832 36 ( ( -LRB- cord-005453-4057qib7 9832 37 0.706±0.032 0.706±0.032 CD cord-005453-4057qib7 9832 38 , , , cord-005453-4057qib7 9832 39 P p NN cord-005453-4057qib7 9832 40 - - HYPH cord-005453-4057qib7 9832 41 Value value NN cord-005453-4057qib7 9832 42 : : : cord-005453-4057qib7 9832 43 0.285 0.285 CD cord-005453-4057qib7 9832 44 ) ) -RRB- cord-005453-4057qib7 9832 45 . . . cord-005453-4057qib7 9833 1 Conclusions conclusion NNS cord-005453-4057qib7 9833 2 : : : cord-005453-4057qib7 9834 1 Incidence incidence NN cord-005453-4057qib7 9834 2 of of IN cord-005453-4057qib7 9834 3 CMV CMV NNP cord-005453-4057qib7 9834 4 infection infection NN cord-005453-4057qib7 9834 5 post post JJ cord-005453-4057qib7 9834 6 - - JJ cord-005453-4057qib7 9834 7 HSCT HSCT NNP cord-005453-4057qib7 9834 8 in in IN cord-005453-4057qib7 9834 9 our -PRON- PRP$ cord-005453-4057qib7 9834 10 center center NN cord-005453-4057qib7 9834 11 is be VBZ cord-005453-4057qib7 9834 12 comparable comparable JJ cord-005453-4057qib7 9834 13 to to IN cord-005453-4057qib7 9834 14 other other JJ cord-005453-4057qib7 9834 15 centers center NNS cord-005453-4057qib7 9834 16 . . . cord-005453-4057qib7 9835 1 Our -PRON- PRP$ cord-005453-4057qib7 9835 2 data datum NNS cord-005453-4057qib7 9835 3 suggest suggest VBP cord-005453-4057qib7 9835 4 that that IN cord-005453-4057qib7 9835 5 donor donor NN cord-005453-4057qib7 9835 6 - - HYPH cord-005453-4057qib7 9835 7 recipient recipient NN cord-005453-4057qib7 9835 8 CMV CMV NNP cord-005453-4057qib7 9835 9 positive positive JJ cord-005453-4057qib7 9835 10 serostatus serostatus NN cord-005453-4057qib7 9835 11 , , , cord-005453-4057qib7 9835 12 haploidentical haploidentical JJ cord-005453-4057qib7 9835 13 Donor Donor NNP cord-005453-4057qib7 9835 14 , , , cord-005453-4057qib7 9835 15 and and CC cord-005453-4057qib7 9835 16 use use NN cord-005453-4057qib7 9835 17 of of IN cord-005453-4057qib7 9835 18 TBI TBI NNP cord-005453-4057qib7 9835 19 based base VBN cord-005453-4057qib7 9835 20 conditioning conditioning NN cord-005453-4057qib7 9835 21 necessitate necessitate VBP cord-005453-4057qib7 9835 22 close close JJ cord-005453-4057qib7 9835 23 attention attention NN cord-005453-4057qib7 9835 24 and and CC cord-005453-4057qib7 9835 25 surveillance surveillance NN cord-005453-4057qib7 9835 26 . . . cord-005453-4057qib7 9836 1 Background background NN cord-005453-4057qib7 9836 2 : : : cord-005453-4057qib7 9837 1 Toxoplasmosis toxoplasmosis NN cord-005453-4057qib7 9837 2 is be VBZ cord-005453-4057qib7 9837 3 a a DT cord-005453-4057qib7 9837 4 rare rare JJ cord-005453-4057qib7 9837 5 and and CC cord-005453-4057qib7 9837 6 underestimated underestimated JJ cord-005453-4057qib7 9837 7 complication complication NN cord-005453-4057qib7 9837 8 following follow VBG cord-005453-4057qib7 9837 9 allogeneic allogeneic IN cord-005453-4057qib7 9837 10 stem stem NN cord-005453-4057qib7 9837 11 cell cell NN cord-005453-4057qib7 9837 12 transplantation transplantation NN cord-005453-4057qib7 9837 13 ( ( -LRB- cord-005453-4057qib7 9837 14 allo allo FW cord-005453-4057qib7 9837 15 - - HYPH cord-005453-4057qib7 9837 16 SCT SCT NNP cord-005453-4057qib7 9837 17 ) ) -RRB- cord-005453-4057qib7 9837 18 with with IN cord-005453-4057qib7 9837 19 an an DT cord-005453-4057qib7 9837 20 often often RB cord-005453-4057qib7 9837 21 fatal fatal JJ cord-005453-4057qib7 9837 22 course course NN cord-005453-4057qib7 9837 23 . . . cord-005453-4057qib7 9838 1 This this DT cord-005453-4057qib7 9838 2 is be VBZ cord-005453-4057qib7 9838 3 in in IN cord-005453-4057qib7 9838 4 part part NN cord-005453-4057qib7 9838 5 due due IN cord-005453-4057qib7 9838 6 to to IN cord-005453-4057qib7 9838 7 limited limited JJ cord-005453-4057qib7 9838 8 diagnostics diagnostic NNS cord-005453-4057qib7 9838 9 relying rely VBG cord-005453-4057qib7 9838 10 mainly mainly RB cord-005453-4057qib7 9838 11 on on IN cord-005453-4057qib7 9838 12 imaging imaging NN cord-005453-4057qib7 9838 13 and and CC cord-005453-4057qib7 9838 14 detection detection NN cord-005453-4057qib7 9838 15 of of IN cord-005453-4057qib7 9838 16 parasite parasite NN cord-005453-4057qib7 9838 17 DNA dna NN cord-005453-4057qib7 9838 18 by by IN cord-005453-4057qib7 9838 19 PCR PCR NNP cord-005453-4057qib7 9838 20 . . . cord-005453-4057qib7 9839 1 We -PRON- PRP cord-005453-4057qib7 9839 2 present present VBP cord-005453-4057qib7 9839 3 here here RB cord-005453-4057qib7 9839 4 eleven eleven CD cord-005453-4057qib7 9839 5 cases case NNS cord-005453-4057qib7 9839 6 of of IN cord-005453-4057qib7 9839 7 Toxoplasma toxoplasma NN cord-005453-4057qib7 9839 8 disease disease NN cord-005453-4057qib7 9839 9 following follow VBG cord-005453-4057qib7 9839 10 allo allo NNP cord-005453-4057qib7 9839 11 - - HYPH cord-005453-4057qib7 9839 12 SCT SCT NNP cord-005453-4057qib7 9839 13 . . . cord-005453-4057qib7 9840 1 Methods method NNS cord-005453-4057qib7 9840 2 : : : cord-005453-4057qib7 9840 3 We -PRON- PRP cord-005453-4057qib7 9840 4 retrospectively retrospectively RB cord-005453-4057qib7 9840 5 analyzed analyze VBD cord-005453-4057qib7 9840 6 534 534 CD cord-005453-4057qib7 9840 7 consecutive consecutive JJ cord-005453-4057qib7 9840 8 adult adult NN cord-005453-4057qib7 9840 9 patients patient NNS cord-005453-4057qib7 9840 10 who who WP cord-005453-4057qib7 9840 11 received receive VBD cord-005453-4057qib7 9840 12 an an DT cord-005453-4057qib7 9840 13 allo allo NN cord-005453-4057qib7 9840 14 - - HYPH cord-005453-4057qib7 9840 15 SCT sct NN cord-005453-4057qib7 9840 16 in in IN cord-005453-4057qib7 9840 17 our -PRON- PRP$ cord-005453-4057qib7 9840 18 Bone Bone NNP cord-005453-4057qib7 9840 19 Marrow Marrow NNP cord-005453-4057qib7 9840 20 Transplant Transplant NNP cord-005453-4057qib7 9840 21 Unit unit NN cord-005453-4057qib7 9840 22 between between IN cord-005453-4057qib7 9840 23 July July NNP cord-005453-4057qib7 9840 24 2008 2008 CD cord-005453-4057qib7 9840 25 and and CC cord-005453-4057qib7 9840 26 July July NNP cord-005453-4057qib7 9840 27 2018 2018 CD cord-005453-4057qib7 9840 28 . . . cord-005453-4057qib7 9841 1 Eleven eleven CD cord-005453-4057qib7 9841 2 ( ( -LRB- cord-005453-4057qib7 9841 3 2 2 CD cord-005453-4057qib7 9841 4 % % NN cord-005453-4057qib7 9841 5 ) ) -RRB- cord-005453-4057qib7 9841 6 of of IN cord-005453-4057qib7 9841 7 these these DT cord-005453-4057qib7 9841 8 patients patient NNS cord-005453-4057qib7 9841 9 were be VBD cord-005453-4057qib7 9841 10 diagnosed diagnose VBN cord-005453-4057qib7 9841 11 of of IN cord-005453-4057qib7 9841 12 Toxoplasma Toxoplasma NNP cord-005453-4057qib7 9841 13 disease disease NN cord-005453-4057qib7 9841 14 . . . cord-005453-4057qib7 9842 1 The the DT cord-005453-4057qib7 9842 2 main main JJ cord-005453-4057qib7 9842 3 characteristics characteristic NNS cord-005453-4057qib7 9842 4 of of IN cord-005453-4057qib7 9842 5 the the DT cord-005453-4057qib7 9842 6 patients patient NNS cord-005453-4057qib7 9842 7 are be VBP cord-005453-4057qib7 9842 8 shown show VBN cord-005453-4057qib7 9842 9 in in IN cord-005453-4057qib7 9842 10 table table NN cord-005453-4057qib7 9842 11 1 1 CD cord-005453-4057qib7 9842 12 . . . cord-005453-4057qib7 9843 1 All all DT cord-005453-4057qib7 9843 2 patients patient NNS cord-005453-4057qib7 9843 3 , , , cord-005453-4057qib7 9843 4 except except IN cord-005453-4057qib7 9843 5 two two CD cord-005453-4057qib7 9843 6 cord cord NN cord-005453-4057qib7 9843 7 blood blood NN cord-005453-4057qib7 9843 8 , , , cord-005453-4057qib7 9843 9 have have VBP cord-005453-4057qib7 9843 10 received receive VBN cord-005453-4057qib7 9843 11 peripheral peripheral JJ cord-005453-4057qib7 9843 12 blood blood NN cord-005453-4057qib7 9843 13 stem stem NN cord-005453-4057qib7 9843 14 cells cell NNS cord-005453-4057qib7 9843 15 . . . cord-005453-4057qib7 9844 1 Fludarabine Fludarabine NNP cord-005453-4057qib7 9844 2 - - HYPH cord-005453-4057qib7 9844 3 based base VBN cord-005453-4057qib7 9844 4 conditioning conditioning NN cord-005453-4057qib7 9844 5 regimes regime NNS cord-005453-4057qib7 9844 6 were be VBD cord-005453-4057qib7 9844 7 used use VBN cord-005453-4057qib7 9844 8 in in IN cord-005453-4057qib7 9844 9 all all DT cord-005453-4057qib7 9844 10 patients patient NNS cord-005453-4057qib7 9844 11 . . . cord-005453-4057qib7 9845 1 Only only RB cord-005453-4057qib7 9845 2 the the DT cord-005453-4057qib7 9845 3 two two CD cord-005453-4057qib7 9845 4 cord cord NN cord-005453-4057qib7 9845 5 blood blood NN cord-005453-4057qib7 9845 6 patients patient NNS cord-005453-4057qib7 9845 7 received receive VBD cord-005453-4057qib7 9845 8 Thymoglobulin Thymoglobulin NNP cord-005453-4057qib7 9845 9 in in IN cord-005453-4057qib7 9845 10 the the DT cord-005453-4057qib7 9845 11 conditioning conditioning NN cord-005453-4057qib7 9845 12 . . . cord-005453-4057qib7 9846 1 Graft graft NN cord-005453-4057qib7 9846 2 - - HYPH cord-005453-4057qib7 9846 3 versus versus IN cord-005453-4057qib7 9846 4 - - HYPH cord-005453-4057qib7 9846 5 host host NN cord-005453-4057qib7 9846 6 disease disease NN cord-005453-4057qib7 9846 7 ( ( -LRB- cord-005453-4057qib7 9846 8 GVHD GVHD NNP cord-005453-4057qib7 9846 9 ) ) -RRB- cord-005453-4057qib7 9846 10 prophylaxis prophylaxis NN cord-005453-4057qib7 9846 11 consisted consist VBD cord-005453-4057qib7 9846 12 on on IN cord-005453-4057qib7 9846 13 tacrolimus tacrolimus NNP cord-005453-4057qib7 9846 14 plus plus CC cord-005453-4057qib7 9846 15 mycophenolate mycophenolate NNP cord-005453-4057qib7 9846 16 mofetil mofetil NNP cord-005453-4057qib7 9846 17 in in IN cord-005453-4057qib7 9846 18 5 5 CD cord-005453-4057qib7 9846 19 ( ( -LRB- cord-005453-4057qib7 9846 20 46 46 CD cord-005453-4057qib7 9846 21 % % NN cord-005453-4057qib7 9846 22 ) ) -RRB- cord-005453-4057qib7 9846 23 patients patient NNS cord-005453-4057qib7 9846 24 and and CC cord-005453-4057qib7 9846 25 post post JJ cord-005453-4057qib7 9846 26 - - JJ cord-005453-4057qib7 9846 27 transplant transplant NN cord-005453-4057qib7 9846 28 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 9846 29 followed follow VBN cord-005453-4057qib7 9846 30 by by IN cord-005453-4057qib7 9846 31 tacrolimus tacrolimus NNP cord-005453-4057qib7 9846 32 in in IN cord-005453-4057qib7 9846 33 4 4 CD cord-005453-4057qib7 9846 34 ( ( -LRB- cord-005453-4057qib7 9846 35 36 36 CD cord-005453-4057qib7 9846 36 % % NN cord-005453-4057qib7 9846 37 ) ) -RRB- cord-005453-4057qib7 9846 38 . . . cord-005453-4057qib7 9847 1 Before before IN cord-005453-4057qib7 9847 2 the the DT cord-005453-4057qib7 9847 3 allo allo NNP cord-005453-4057qib7 9847 4 - - HYPH cord-005453-4057qib7 9847 5 SCT SCT NNP cord-005453-4057qib7 9847 6 was be VBD cord-005453-4057qib7 9847 7 performed perform VBN cord-005453-4057qib7 9847 8 the the DT cord-005453-4057qib7 9847 9 IgG IgG NNP cord-005453-4057qib7 9847 10 / / SYM cord-005453-4057qib7 9847 11 IgM IgM NNP cord-005453-4057qib7 9847 12 Toxoplasma Toxoplasma NNP cord-005453-4057qib7 9847 13 serology serology NN cord-005453-4057qib7 9847 14 of of IN cord-005453-4057qib7 9847 15 the the DT cord-005453-4057qib7 9847 16 recipient recipient NN cord-005453-4057qib7 9847 17 and and CC cord-005453-4057qib7 9847 18 donor donor NN cord-005453-4057qib7 9847 19 . . . cord-005453-4057qib7 9848 1 We -PRON- PRP cord-005453-4057qib7 9848 2 reviewed review VBD cord-005453-4057qib7 9848 3 the the DT cord-005453-4057qib7 9848 4 absolute absolute JJ cord-005453-4057qib7 9848 5 lymphocyte lymphocyte NN cord-005453-4057qib7 9848 6 count count NN cord-005453-4057qib7 9848 7 ( ( -LRB- cord-005453-4057qib7 9848 8 ALC ALC NNP cord-005453-4057qib7 9848 9 ) ) -RRB- cord-005453-4057qib7 9848 10 and and CC cord-005453-4057qib7 9848 11 CD4 CD4 NNP cord-005453-4057qib7 9848 12 + + CC cord-005453-4057qib7 9848 13 lymphocyte lymphocyte NN cord-005453-4057qib7 9848 14 count count NN cord-005453-4057qib7 9848 15 within within IN cord-005453-4057qib7 9848 16 four four CD cord-005453-4057qib7 9848 17 weeks week NNS cord-005453-4057qib7 9848 18 prior prior RB cord-005453-4057qib7 9848 19 to to IN cord-005453-4057qib7 9848 20 the the DT cord-005453-4057qib7 9848 21 diagnosis diagnosis NN cord-005453-4057qib7 9848 22 of of IN cord-005453-4057qib7 9848 23 toxoplasmosis toxoplasmosis NN cord-005453-4057qib7 9848 24 , , , cord-005453-4057qib7 9848 25 and and CC cord-005453-4057qib7 9848 26 if if IN cord-005453-4057qib7 9848 27 the the DT cord-005453-4057qib7 9848 28 patients patient NNS cord-005453-4057qib7 9848 29 took take VBD cord-005453-4057qib7 9848 30 effective effective JJ cord-005453-4057qib7 9848 31 primary primary JJ cord-005453-4057qib7 9848 32 prophylaxis prophylaxis NN cord-005453-4057qib7 9848 33 for for IN cord-005453-4057qib7 9848 34 this this DT cord-005453-4057qib7 9848 35 parasite parasite NN cord-005453-4057qib7 9848 36 . . . cord-005453-4057qib7 9849 1 Toxoplasma toxoplasma NN cord-005453-4057qib7 9849 2 disease disease NN cord-005453-4057qib7 9849 3 was be VBD cord-005453-4057qib7 9849 4 defined define VBN cord-005453-4057qib7 9849 5 as as IN cord-005453-4057qib7 9849 6 the the DT cord-005453-4057qib7 9849 7 presence presence NN cord-005453-4057qib7 9849 8 of of IN cord-005453-4057qib7 9849 9 Toxoplasma toxoplasma JJ cord-005453-4057qib7 9849 10 infection infection NN cord-005453-4057qib7 9849 11 plus plus IN cord-005453-4057qib7 9849 12 clinical clinical JJ cord-005453-4057qib7 9849 13 , , , cord-005453-4057qib7 9849 14 radiological radiological JJ cord-005453-4057qib7 9849 15 or or CC cord-005453-4057qib7 9849 16 pathological pathological JJ cord-005453-4057qib7 9849 17 evidence evidence NN cord-005453-4057qib7 9849 18 . . . cord-005453-4057qib7 9850 1 Toxoplasma toxoplasma NN cord-005453-4057qib7 9850 2 disease disease NN cord-005453-4057qib7 9850 3 was be VBD cord-005453-4057qib7 9850 4 considered consider VBN cord-005453-4057qib7 9850 5 the the DT cord-005453-4057qib7 9850 6 main main JJ cord-005453-4057qib7 9850 7 cause cause NN cord-005453-4057qib7 9850 8 of of IN cord-005453-4057qib7 9850 9 death death NN cord-005453-4057qib7 9850 10 when when WRB cord-005453-4057qib7 9850 11 no no DT cord-005453-4057qib7 9850 12 other other JJ cord-005453-4057qib7 9850 13 major major JJ cord-005453-4057qib7 9850 14 life life NN cord-005453-4057qib7 9850 15 - - HYPH cord-005453-4057qib7 9850 16 threatening threaten VBG cord-005453-4057qib7 9850 17 infection infection NN cord-005453-4057qib7 9850 18 or or CC cord-005453-4057qib7 9850 19 other other JJ cord-005453-4057qib7 9850 20 potential potential JJ cord-005453-4057qib7 9850 21 fatal fatal JJ cord-005453-4057qib7 9850 22 complication complication NN cord-005453-4057qib7 9850 23 occurred occur VBD cord-005453-4057qib7 9850 24 immediately immediately RB cord-005453-4057qib7 9850 25 before before IN cord-005453-4057qib7 9850 26 death death NN cord-005453-4057qib7 9850 27 . . . cord-005453-4057qib7 9851 1 Results result NNS cord-005453-4057qib7 9851 2 : : : cord-005453-4057qib7 9852 1 Median median JJ cord-005453-4057qib7 9852 2 ( ( -LRB- cord-005453-4057qib7 9852 3 range range NN cord-005453-4057qib7 9852 4 ) ) -RRB- cord-005453-4057qib7 9852 5 age age NN cord-005453-4057qib7 9852 6 ( ( -LRB- cord-005453-4057qib7 9852 7 years year NNS cord-005453-4057qib7 9852 8 ) ) -RRB- cord-005453-4057qib7 9852 9 of of IN cord-005453-4057qib7 9852 10 the the DT cord-005453-4057qib7 9852 11 eleven eleven CD cord-005453-4057qib7 9852 12 patients patient NNS cord-005453-4057qib7 9852 13 diagnosed diagnose VBN cord-005453-4057qib7 9852 14 with with IN cord-005453-4057qib7 9852 15 Toxoplasma toxoplasma NN cord-005453-4057qib7 9852 16 disease disease NN cord-005453-4057qib7 9852 17 was be VBD cord-005453-4057qib7 9852 18 54 54 CD cord-005453-4057qib7 9852 19 ( ( -LRB- cord-005453-4057qib7 9852 20 19 19 CD cord-005453-4057qib7 9852 21 - - SYM cord-005453-4057qib7 9852 22 69 69 CD cord-005453-4057qib7 9852 23 ) ) -RRB- cord-005453-4057qib7 9852 24 . . . cord-005453-4057qib7 9853 1 For for IN cord-005453-4057qib7 9853 2 pancytopenia pancytopenia NNP cord-005453-4057qib7 9853 3 , , , cord-005453-4057qib7 9853 4 no no DT cord-005453-4057qib7 9853 5 patient patient NN cord-005453-4057qib7 9853 6 received receive VBD cord-005453-4057qib7 9853 7 trimethoprimsufmethoxazole trimethoprimsufmethoxazole NNP cord-005453-4057qib7 9853 8 ( ( -LRB- cord-005453-4057qib7 9853 9 TMP TMP NNP cord-005453-4057qib7 9853 10 - - HYPH cord-005453-4057qib7 9853 11 SMZ SMZ NNP cord-005453-4057qib7 9853 12 ) ) -RRB- cord-005453-4057qib7 9853 13 but but CC cord-005453-4057qib7 9853 14 pentamidine pentamidine NN cord-005453-4057qib7 9853 15 for for IN cord-005453-4057qib7 9853 16 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9853 17 jirovecii jirovecii NNP cord-005453-4057qib7 9853 18 - - HYPH cord-005453-4057qib7 9853 19 pneumonia pneumonia NNP cord-005453-4057qib7 9853 20 ( ( -LRB- cord-005453-4057qib7 9853 21 PcP PcP NNP cord-005453-4057qib7 9853 22 ) ) -RRB- cord-005453-4057qib7 9853 23 prophylaxis prophylaxis NN cord-005453-4057qib7 9853 24 in in IN cord-005453-4057qib7 9853 25 10 10 CD cord-005453-4057qib7 9853 26 cases case NNS cord-005453-4057qib7 9853 27 and and CC cord-005453-4057qib7 9853 28 atovaquone atovaquone NN cord-005453-4057qib7 9853 29 in in IN cord-005453-4057qib7 9853 30 one one CD cord-005453-4057qib7 9853 31 . . . cord-005453-4057qib7 9854 1 Toxoplasma toxoplasma NN cord-005453-4057qib7 9854 2 serology serology NN cord-005453-4057qib7 9854 3 pretransplant pretransplant NN cord-005453-4057qib7 9854 4 was be VBD cord-005453-4057qib7 9854 5 positive positive JJ cord-005453-4057qib7 9854 6 ( ( -LRB- cord-005453-4057qib7 9854 7 IgG+/IgM- IgG+/IgM- NNP cord-005453-4057qib7 9854 8 ) ) -RRB- cord-005453-4057qib7 9855 1 in in IN cord-005453-4057qib7 9855 2 ten ten CD cord-005453-4057qib7 9855 3 of of IN cord-005453-4057qib7 9855 4 the the DT cord-005453-4057qib7 9855 5 eleven eleven CD cord-005453-4057qib7 9855 6 patients patient NNS cord-005453-4057qib7 9855 7 . . . cord-005453-4057qib7 9856 1 All all DT cord-005453-4057qib7 9856 2 donors donor NNS cord-005453-4057qib7 9856 3 were be VBD cord-005453-4057qib7 9856 4 seronegative seronegative JJ cord-005453-4057qib7 9856 5 ( ( -LRB- cord-005453-4057qib7 9856 6 IgG-/IgM- IgG-/IgM- NNP cord-005453-4057qib7 9856 7 ) ) -RRB- cord-005453-4057qib7 9856 8 except except IN cord-005453-4057qib7 9856 9 two two CD cord-005453-4057qib7 9856 10 . . . cord-005453-4057qib7 9857 1 Toxoplasmosis toxoplasmosis NN cord-005453-4057qib7 9857 2 was be VBD cord-005453-4057qib7 9857 3 diagnosed diagnose VBN cord-005453-4057qib7 9857 4 a a DT cord-005453-4057qib7 9857 5 median median NN cord-005453-4057qib7 9857 6 ( ( -LRB- cord-005453-4057qib7 9857 7 range range NN cord-005453-4057qib7 9857 8 ) ) -RRB- cord-005453-4057qib7 9857 9 of of IN cord-005453-4057qib7 9857 10 85 85 CD cord-005453-4057qib7 9857 11 days day NNS cord-005453-4057qib7 9857 12 ( ( -LRB- cord-005453-4057qib7 9857 13 35 35 CD cord-005453-4057qib7 9857 14 - - SYM cord-005453-4057qib7 9857 15 330 330 CD cord-005453-4057qib7 9857 16 ) ) -RRB- cord-005453-4057qib7 9857 17 post post NN cord-005453-4057qib7 9857 18 allo allo NNP cord-005453-4057qib7 9857 19 - - HYPH cord-005453-4057qib7 9857 20 STC STC NNP cord-005453-4057qib7 9857 21 . . . cord-005453-4057qib7 9858 1 The the DT cord-005453-4057qib7 9858 2 clinical clinical JJ cord-005453-4057qib7 9858 3 presentations presentation NNS cord-005453-4057qib7 9858 4 were be VBD cord-005453-4057qib7 9858 5 as as RB cord-005453-4057qib7 9858 6 cerebral cerebral JJ cord-005453-4057qib7 9858 7 - - : cord-005453-4057qib7 9858 8 encephalitis encephalitis JJ cord-005453-4057qib7 9858 9 ( ( -LRB- cord-005453-4057qib7 9858 10 n=4 n=4 NNS cord-005453-4057qib7 9858 11 ) ) -RRB- cord-005453-4057qib7 9858 12 , , , cord-005453-4057qib7 9858 13 chorioretinitis chorioretinitis NNP cord-005453-4057qib7 9858 14 ( ( -LRB- cord-005453-4057qib7 9858 15 n=3 n=3 NN cord-005453-4057qib7 9858 16 ) ) -RRB- cord-005453-4057qib7 9858 17 , , , cord-005453-4057qib7 9858 18 pneumonitis pneumonitis NNP cord-005453-4057qib7 9858 19 ( ( -LRB- cord-005453-4057qib7 9858 20 n=2 n=2 NNS cord-005453-4057qib7 9858 21 ) ) -RRB- cord-005453-4057qib7 9858 22 and and CC cord-005453-4057qib7 9858 23 disseminated disseminate VBN cord-005453-4057qib7 9858 24 toxoplasmosis toxoplasmosis NN cord-005453-4057qib7 9858 25 ( ( -LRB- cord-005453-4057qib7 9858 26 n=2 n=2 NNS cord-005453-4057qib7 9858 27 ) ) -RRB- cord-005453-4057qib7 9858 28 . . . cord-005453-4057qib7 9859 1 One one CD cord-005453-4057qib7 9859 2 case case NN cord-005453-4057qib7 9859 3 , , , cord-005453-4057qib7 9859 4 patient patient JJ cord-005453-4057qib7 9859 5 and and CC cord-005453-4057qib7 9859 6 donor donor NN cord-005453-4057qib7 9859 7 seronegative seronegative JJ cord-005453-4057qib7 9859 8 pre pre JJ cord-005453-4057qib7 9859 9 - - NN cord-005453-4057qib7 9859 10 transplant transplant NN cord-005453-4057qib7 9859 11 , , , cord-005453-4057qib7 9859 12 was be VBD cord-005453-4057qib7 9859 13 presented present VBN cord-005453-4057qib7 9859 14 as as IN cord-005453-4057qib7 9859 15 a a DT cord-005453-4057qib7 9859 16 primary primary JJ cord-005453-4057qib7 9859 17 infection infection NN cord-005453-4057qib7 9859 18 in in IN cord-005453-4057qib7 9859 19 form form NN cord-005453-4057qib7 9859 20 of of IN cord-005453-4057qib7 9859 21 chorioretinitis chorioretinitis NNP cord-005453-4057qib7 9859 22 . . . cord-005453-4057qib7 9860 1 All all DT cord-005453-4057qib7 9860 2 three three CD cord-005453-4057qib7 9860 3 patients patient NNS cord-005453-4057qib7 9860 4 with with IN cord-005453-4057qib7 9860 5 chorioretinitis chorioretinitis NNP cord-005453-4057qib7 9860 6 were be VBD cord-005453-4057qib7 9860 7 diagnosed diagnose VBN cord-005453-4057qib7 9860 8 after after IN cord-005453-4057qib7 9860 9 day day NN cord-005453-4057qib7 9860 10 +100 +100 NNS cord-005453-4057qib7 9860 11 of of IN cord-005453-4057qib7 9860 12 allo allo NN cord-005453-4057qib7 9860 13 - - HYPH cord-005453-4057qib7 9860 14 SCT SCT NNP cord-005453-4057qib7 9860 15 . . . cord-005453-4057qib7 9861 1 At at IN cord-005453-4057qib7 9861 2 the the DT cord-005453-4057qib7 9861 3 time time NN cord-005453-4057qib7 9861 4 of of IN cord-005453-4057qib7 9861 5 Toxoplasma Toxoplasma NNP cord-005453-4057qib7 9861 6 disease disease NN cord-005453-4057qib7 9861 7 , , , cord-005453-4057qib7 9861 8 8 8 CD cord-005453-4057qib7 9861 9 of of IN cord-005453-4057qib7 9861 10 11 11 CD cord-005453-4057qib7 9861 11 ( ( -LRB- cord-005453-4057qib7 9861 12 73 73 CD cord-005453-4057qib7 9861 13 % % NN cord-005453-4057qib7 9861 14 ) ) -RRB- cord-005453-4057qib7 9861 15 of of IN cord-005453-4057qib7 9861 16 patients patient NNS cord-005453-4057qib7 9861 17 had have VBD cord-005453-4057qib7 9861 18 an an DT cord-005453-4057qib7 9861 19 ALC alc NN cord-005453-4057qib7 9861 20 < < XX cord-005453-4057qib7 9861 21 500 500 CD cord-005453-4057qib7 9861 22 cells cell NNS cord-005453-4057qib7 9861 23 / / SYM cord-005453-4057qib7 9861 24 μl μl VBP cord-005453-4057qib7 9861 25 and and CC cord-005453-4057qib7 9861 26 all all DT cord-005453-4057qib7 9861 27 of of IN cord-005453-4057qib7 9861 28 them -PRON- PRP cord-005453-4057qib7 9861 29 with with IN cord-005453-4057qib7 9861 30 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 9861 31 therapy therapy NN cord-005453-4057qib7 9861 32 and and CC cord-005453-4057qib7 9861 33 corticosteroids corticosteroid NNS cord-005453-4057qib7 9861 34 for for IN cord-005453-4057qib7 9861 35 acute acute JJ cord-005453-4057qib7 9861 36 or or CC cord-005453-4057qib7 9861 37 chronic chronic JJ cord-005453-4057qib7 9861 38 GVHD GVHD NNP cord-005453-4057qib7 9861 39 . . . cord-005453-4057qib7 9862 1 We -PRON- PRP cord-005453-4057qib7 9862 2 had have VBD cord-005453-4057qib7 9862 3 CD4 CD4 NNP cord-005453-4057qib7 9862 4 + + CC cord-005453-4057qib7 9862 5 lymphocyte lymphocyte NN cord-005453-4057qib7 9862 6 count count NN cord-005453-4057qib7 9862 7 only only RB cord-005453-4057qib7 9862 8 in in IN cord-005453-4057qib7 9862 9 four four CD cord-005453-4057qib7 9862 10 patients patient NNS cord-005453-4057qib7 9862 11 and and CC cord-005453-4057qib7 9862 12 in in IN cord-005453-4057qib7 9862 13 three three CD cord-005453-4057qib7 9862 14 of of IN cord-005453-4057qib7 9862 15 them -PRON- PRP cord-005453-4057qib7 9862 16 was be VBD cord-005453-4057qib7 9862 17 < < XX cord-005453-4057qib7 9862 18 200 200 CD cord-005453-4057qib7 9862 19 cells/ cells/ CD cord-005453-4057qib7 9863 1 μL. μL. NNP cord-005453-4057qib7 9863 2 Eight eight CD cord-005453-4057qib7 9863 3 of of IN cord-005453-4057qib7 9863 4 the the DT cord-005453-4057qib7 9863 5 eleven eleven CD cord-005453-4057qib7 9863 6 ( ( -LRB- cord-005453-4057qib7 9863 7 73 73 CD cord-005453-4057qib7 9863 8 % % NN cord-005453-4057qib7 9863 9 ) ) -RRB- cord-005453-4057qib7 9864 1 patients patient NNS cord-005453-4057qib7 9864 2 died die VBD cord-005453-4057qib7 9864 3 , , , cord-005453-4057qib7 9864 4 with with IN cord-005453-4057qib7 9864 5 a a DT cord-005453-4057qib7 9864 6 median median NN cord-005453-4057qib7 9864 7 ( ( -LRB- cord-005453-4057qib7 9864 8 range range NN cord-005453-4057qib7 9864 9 ) ) -RRB- cord-005453-4057qib7 9864 10 of of IN cord-005453-4057qib7 9864 11 21 21 CD cord-005453-4057qib7 9864 12 days day NNS cord-005453-4057qib7 9864 13 ( ( -LRB- cord-005453-4057qib7 9864 14 9 9 CD cord-005453-4057qib7 9864 15 - - SYM cord-005453-4057qib7 9864 16 65 65 CD cord-005453-4057qib7 9864 17 ) ) -RRB- cord-005453-4057qib7 9864 18 since since IN cord-005453-4057qib7 9864 19 diagnosis diagnosis NN cord-005453-4057qib7 9864 20 of of IN cord-005453-4057qib7 9864 21 toxoplasmosis toxoplasmosis NN cord-005453-4057qib7 9864 22 , , , cord-005453-4057qib7 9864 23 and and CC cord-005453-4057qib7 9864 24 in in IN cord-005453-4057qib7 9864 25 6 6 CD cord-005453-4057qib7 9864 26 of of IN cord-005453-4057qib7 9864 27 them -PRON- PRP cord-005453-4057qib7 9864 28 the the DT cord-005453-4057qib7 9864 29 Toxoplasma Toxoplasma NNP cord-005453-4057qib7 9864 30 disease disease NN cord-005453-4057qib7 9864 31 was be VBD cord-005453-4057qib7 9864 32 the the DT cord-005453-4057qib7 9864 33 main main JJ cord-005453-4057qib7 9864 34 cause cause NN cord-005453-4057qib7 9864 35 of of IN cord-005453-4057qib7 9864 36 death death NN cord-005453-4057qib7 9864 37 . . . cord-005453-4057qib7 9865 1 Conclusions conclusion NNS cord-005453-4057qib7 9865 2 : : : cord-005453-4057qib7 9866 1 In in IN cord-005453-4057qib7 9866 2 our -PRON- PRP$ cord-005453-4057qib7 9866 3 series series NN cord-005453-4057qib7 9866 4 , , , cord-005453-4057qib7 9866 5 the the DT cord-005453-4057qib7 9866 6 incidence incidence NN cord-005453-4057qib7 9866 7 of of IN cord-005453-4057qib7 9866 8 Toxoplasma toxoplasma JJ cord-005453-4057qib7 9866 9 disease disease NN cord-005453-4057qib7 9866 10 after after IN cord-005453-4057qib7 9866 11 allo allo NN cord-005453-4057qib7 9866 12 - - HYPH cord-005453-4057qib7 9866 13 SCT SCT NNP cord-005453-4057qib7 9866 14 is be VBZ cord-005453-4057qib7 9866 15 low low JJ cord-005453-4057qib7 9866 16 and and CC cord-005453-4057qib7 9866 17 is be VBZ cord-005453-4057qib7 9866 18 related relate VBN cord-005453-4057qib7 9866 19 to to IN cord-005453-4057qib7 9866 20 high high JJ cord-005453-4057qib7 9866 21 mortality mortality NN cord-005453-4057qib7 9866 22 , , , cord-005453-4057qib7 9866 23 in in IN cord-005453-4057qib7 9866 24 accordance accordance NN cord-005453-4057qib7 9866 25 with with IN cord-005453-4057qib7 9866 26 what what WP cord-005453-4057qib7 9866 27 has have VBZ cord-005453-4057qib7 9866 28 been be VBN cord-005453-4057qib7 9866 29 reported report VBN cord-005453-4057qib7 9866 30 by by IN cord-005453-4057qib7 9866 31 other other JJ cord-005453-4057qib7 9866 32 groups group NNS cord-005453-4057qib7 9866 33 . . . cord-005453-4057qib7 9867 1 Positive positive JJ cord-005453-4057qib7 9867 2 pre pre JJ cord-005453-4057qib7 9867 3 - - JJ cord-005453-4057qib7 9867 4 transplant transplant JJ cord-005453-4057qib7 9867 5 serology serology NN cord-005453-4057qib7 9867 6 and and CC cord-005453-4057qib7 9867 7 GVHD GVHD NNP cord-005453-4057qib7 9867 8 and and CC cord-005453-4057qib7 9867 9 its -PRON- PRP$ cord-005453-4057qib7 9867 10 treatment treatment NN cord-005453-4057qib7 9867 11 were be VBD cord-005453-4057qib7 9867 12 factors factor NNS cord-005453-4057qib7 9867 13 strongly strongly RB cord-005453-4057qib7 9867 14 related relate VBN cord-005453-4057qib7 9867 15 with with IN cord-005453-4057qib7 9867 16 toxoplasmosis toxoplasmosi NNS cord-005453-4057qib7 9867 17 . . . cord-005453-4057qib7 9868 1 We -PRON- PRP cord-005453-4057qib7 9868 2 encourage encourage VBP cord-005453-4057qib7 9868 3 the the DT cord-005453-4057qib7 9868 4 use use NN cord-005453-4057qib7 9868 5 of of IN cord-005453-4057qib7 9868 6 TMP tmp NN cord-005453-4057qib7 9868 7 - - HYPH cord-005453-4057qib7 9868 8 SMZ SMZ NNP cord-005453-4057qib7 9868 9 instead instead RB cord-005453-4057qib7 9868 10 of of IN cord-005453-4057qib7 9868 11 pentamidine pentamidine NNP cord-005453-4057qib7 9868 12 for for IN cord-005453-4057qib7 9868 13 PcP pcp JJ cord-005453-4057qib7 9868 14 - - HYPH cord-005453-4057qib7 9868 15 pneumonia pneumonia NN cord-005453-4057qib7 9868 16 prophylaxis prophylaxis NN cord-005453-4057qib7 9868 17 in in IN cord-005453-4057qib7 9868 18 patients patient NNS cord-005453-4057qib7 9868 19 seropositive seropositive JJ cord-005453-4057qib7 9868 20 for for IN cord-005453-4057qib7 9868 21 Toxoplasma toxoplasma NN cord-005453-4057qib7 9868 22 gondii gondii NNP cord-005453-4057qib7 9868 23 pre pre NN cord-005453-4057qib7 9868 24 - - NN cord-005453-4057qib7 9868 25 transplant transplant NN cord-005453-4057qib7 9868 26 . . . cord-005453-4057qib7 9869 1 Clinical clinical JJ cord-005453-4057qib7 9869 2 Trial Trial NNP cord-005453-4057qib7 9869 3 Registry Registry NNP cord-005453-4057qib7 9869 4 : : : cord-005453-4057qib7 9870 1 Data datum NNS cord-005453-4057qib7 9870 2 about about IN cord-005453-4057qib7 9870 3 its -PRON- PRP$ cord-005453-4057qib7 9870 4 epidemiology epidemiology NN cord-005453-4057qib7 9870 5 in in IN cord-005453-4057qib7 9870 6 children child NNS cord-005453-4057qib7 9870 7 are be VBP cord-005453-4057qib7 9870 8 scarce scarce JJ cord-005453-4057qib7 9870 9 . . . cord-005453-4057qib7 9871 1 We -PRON- PRP cord-005453-4057qib7 9871 2 retrospectively retrospectively RB cord-005453-4057qib7 9871 3 analyzed analyze VBD cord-005453-4057qib7 9871 4 the the DT cord-005453-4057qib7 9871 5 incidence incidence NN cord-005453-4057qib7 9871 6 , , , cord-005453-4057qib7 9871 7 the the DT cord-005453-4057qib7 9871 8 severity severity NN cord-005453-4057qib7 9871 9 and and CC cord-005453-4057qib7 9871 10 the the DT cord-005453-4057qib7 9871 11 risk risk NN cord-005453-4057qib7 9871 12 factors factor NNS cord-005453-4057qib7 9871 13 that that WDT cord-005453-4057qib7 9871 14 contribute contribute VBP cord-005453-4057qib7 9871 15 to to IN cord-005453-4057qib7 9871 16 the the DT cord-005453-4057qib7 9871 17 manifestation manifestation NN cord-005453-4057qib7 9871 18 of of IN cord-005453-4057qib7 9871 19 this this DT cord-005453-4057qib7 9871 20 complication complication NN cord-005453-4057qib7 9871 21 in in IN cord-005453-4057qib7 9871 22 a a DT cord-005453-4057qib7 9871 23 pediatric pediatric JJ cord-005453-4057qib7 9871 24 population population NN cord-005453-4057qib7 9871 25 . . . cord-005453-4057qib7 9872 1 Methods method NNS cord-005453-4057qib7 9872 2 : : : cord-005453-4057qib7 9872 3 During during IN cord-005453-4057qib7 9872 4 a a DT cord-005453-4057qib7 9872 5 10-year 10-year CD cord-005453-4057qib7 9872 6 period period NN cord-005453-4057qib7 9872 7 ( ( -LRB- cord-005453-4057qib7 9872 8 January January NNP cord-005453-4057qib7 9872 9 2008 2008 CD cord-005453-4057qib7 9872 10 -June -June NNP cord-005453-4057qib7 9872 11 2018 2018 CD cord-005453-4057qib7 9872 12 ) ) -RRB- cord-005453-4057qib7 9873 1 we -PRON- PRP cord-005453-4057qib7 9873 2 performed perform VBD cord-005453-4057qib7 9873 3 in in IN cord-005453-4057qib7 9873 4 our -PRON- PRP$ cord-005453-4057qib7 9873 5 center center NN cord-005453-4057qib7 9873 6 376 376 CD cord-005453-4057qib7 9873 7 allogeneic allogeneic NN cord-005453-4057qib7 9873 8 transplantations transplantation NNS cord-005453-4057qib7 9873 9 , , , cord-005453-4057qib7 9873 10 237 237 CD cord-005453-4057qib7 9873 11 for for IN cord-005453-4057qib7 9873 12 malignant malignant JJ cord-005453-4057qib7 9873 13 hematological hematological JJ cord-005453-4057qib7 9873 14 diseases disease NNS cord-005453-4057qib7 9873 15 and and CC cord-005453-4057qib7 9873 16 139 139 CD cord-005453-4057qib7 9873 17 for for IN cord-005453-4057qib7 9873 18 non non JJ cord-005453-4057qib7 9873 19 - - JJ cord-005453-4057qib7 9873 20 malignant malignant JJ cord-005453-4057qib7 9873 21 . . . cord-005453-4057qib7 9874 1 The the DT cord-005453-4057qib7 9874 2 majority majority NN cord-005453-4057qib7 9874 3 of of IN cord-005453-4057qib7 9874 4 our -PRON- PRP$ cord-005453-4057qib7 9874 5 patients patient NNS cord-005453-4057qib7 9874 6 received receive VBD cord-005453-4057qib7 9874 7 myeloablative myeloablative JJ cord-005453-4057qib7 9874 8 conditioning conditioning NN cord-005453-4057qib7 9874 9 regimens regimen NNS cord-005453-4057qib7 9874 10 . . . cord-005453-4057qib7 9875 1 Diagnostic diagnostic JJ cord-005453-4057qib7 9875 2 criteria criterion NNS cord-005453-4057qib7 9875 3 of of IN cord-005453-4057qib7 9875 4 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 9875 5 cystitis cystiti NNS cord-005453-4057qib7 9875 6 were be VBD cord-005453-4057qib7 9875 7 the the DT cord-005453-4057qib7 9875 8 detection detection NN cord-005453-4057qib7 9875 9 of of IN cord-005453-4057qib7 9875 10 the the DT cord-005453-4057qib7 9875 11 virus virus NN cord-005453-4057qib7 9875 12 with with IN cord-005453-4057qib7 9875 13 PCR PCR NNP cord-005453-4057qib7 9875 14 in in IN cord-005453-4057qib7 9875 15 urine urine NN cord-005453-4057qib7 9875 16 samples sample NNS cord-005453-4057qib7 9875 17 and/or and/or CC cord-005453-4057qib7 9875 18 in in IN cord-005453-4057qib7 9875 19 blood blood NN cord-005453-4057qib7 9875 20 samples sample NNS cord-005453-4057qib7 9875 21 , , , cord-005453-4057qib7 9875 22 in in IN cord-005453-4057qib7 9875 23 combination combination NN cord-005453-4057qib7 9875 24 with with IN cord-005453-4057qib7 9875 25 hematuria hematuria NN cord-005453-4057qib7 9875 26 and and CC cord-005453-4057qib7 9875 27 lower low JJR cord-005453-4057qib7 9875 28 urinary urinary JJ cord-005453-4057qib7 9875 29 tract tract NN cord-005453-4057qib7 9875 30 symptoms symptom NNS cord-005453-4057qib7 9875 31 ( ( -LRB- cord-005453-4057qib7 9875 32 dysuria dysuria NNP cord-005453-4057qib7 9875 33 , , , cord-005453-4057qib7 9875 34 urinary urinary JJ cord-005453-4057qib7 9875 35 frequency frequency NN cord-005453-4057qib7 9875 36 , , , cord-005453-4057qib7 9875 37 urgency urgency NN cord-005453-4057qib7 9875 38 , , , cord-005453-4057qib7 9875 39 suprapubic suprapubic NN cord-005453-4057qib7 9875 40 pain pain NN cord-005453-4057qib7 9875 41 ) ) -RRB- cord-005453-4057qib7 9875 42 that that WDT cord-005453-4057qib7 9875 43 could could MD cord-005453-4057qib7 9875 44 n't not RB cord-005453-4057qib7 9875 45 be be VB cord-005453-4057qib7 9875 46 attributed attribute VBN cord-005453-4057qib7 9875 47 to to IN cord-005453-4057qib7 9875 48 any any DT cord-005453-4057qib7 9875 49 other other JJ cord-005453-4057qib7 9875 50 reason reason NN cord-005453-4057qib7 9875 51 . . . cord-005453-4057qib7 9876 1 We -PRON- PRP cord-005453-4057qib7 9876 2 defined define VBD cord-005453-4057qib7 9876 3 the the DT cord-005453-4057qib7 9876 4 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 9876 5 cystitis cystitis NN cord-005453-4057qib7 9876 6 as as IN cord-005453-4057qib7 9876 7 severe severe JJ cord-005453-4057qib7 9876 8 when when WRB cord-005453-4057qib7 9876 9 one one CD cord-005453-4057qib7 9876 10 of of IN cord-005453-4057qib7 9876 11 the the DT cord-005453-4057qib7 9876 12 following following JJ cord-005453-4057qib7 9876 13 factors factor NNS cord-005453-4057qib7 9876 14 was be VBD cord-005453-4057qib7 9876 15 present present JJ cord-005453-4057qib7 9876 16 : : : cord-005453-4057qib7 9876 17 formation formation NN cord-005453-4057qib7 9876 18 of of IN cord-005453-4057qib7 9876 19 clots clot NNS cord-005453-4057qib7 9876 20 and and CC cord-005453-4057qib7 9876 21 continuous continuous JJ cord-005453-4057qib7 9876 22 bladder bladder NN cord-005453-4057qib7 9876 23 irrigation irrigation NN cord-005453-4057qib7 9876 24 , , , cord-005453-4057qib7 9876 25 obstructive obstructive JJ cord-005453-4057qib7 9876 26 uropathy uropathy NNP cord-005453-4057qib7 9876 27 with with IN cord-005453-4057qib7 9876 28 creatinine creatinine NN cord-005453-4057qib7 9876 29 elevation elevation NN cord-005453-4057qib7 9876 30 or or CC cord-005453-4057qib7 9876 31 need need NN cord-005453-4057qib7 9876 32 for for IN cord-005453-4057qib7 9876 33 urological urological JJ cord-005453-4057qib7 9876 34 intervention intervention NN cord-005453-4057qib7 9876 35 . . . cord-005453-4057qib7 9877 1 Results result NNS cord-005453-4057qib7 9877 2 : : : cord-005453-4057qib7 9878 1 A a DT cord-005453-4057qib7 9878 2 total total NN cord-005453-4057qib7 9878 3 of of IN cord-005453-4057qib7 9878 4 376 376 CD cord-005453-4057qib7 9878 5 patients patient NNS cord-005453-4057qib7 9878 6 with with IN cord-005453-4057qib7 9878 7 median median JJ cord-005453-4057qib7 9878 8 age age NN cord-005453-4057qib7 9878 9 7,2 7,2 CD cord-005453-4057qib7 9878 10 years year NNS cord-005453-4057qib7 9879 1 ( ( -LRB- cord-005453-4057qib7 9879 2 0,5 0,5 CD cord-005453-4057qib7 9879 3 - - SYM cord-005453-4057qib7 9879 4 20 20 CD cord-005453-4057qib7 9879 5 ) ) -RRB- cord-005453-4057qib7 9879 6 were be VBD cord-005453-4057qib7 9879 7 studied study VBN cord-005453-4057qib7 9879 8 . . . cord-005453-4057qib7 9880 1 37 37 CD cord-005453-4057qib7 9880 2 children child NNS cord-005453-4057qib7 9880 3 ( ( -LRB- cord-005453-4057qib7 9880 4 10 10 CD cord-005453-4057qib7 9880 5 % % NN cord-005453-4057qib7 9880 6 , , , cord-005453-4057qib7 9880 7 95 95 CD cord-005453-4057qib7 9880 8 % % NN cord-005453-4057qib7 9880 9 CI ci NN cord-005453-4057qib7 9880 10 , , , cord-005453-4057qib7 9880 11 7,2 7,2 CD cord-005453-4057qib7 9880 12 - - HYPH cord-005453-4057qib7 9880 13 13,3 13,3 CD cord-005453-4057qib7 9880 14 ) ) -RRB- cord-005453-4057qib7 9880 15 manifested manifest VBD cord-005453-4057qib7 9880 16 BK BK NNP cord-005453-4057qib7 9880 17 virus virus NN cord-005453-4057qib7 9880 18 associated associate VBD cord-005453-4057qib7 9880 19 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 9880 20 cystitis cystitis NN cord-005453-4057qib7 9880 21 with with IN cord-005453-4057qib7 9880 22 median median JJ cord-005453-4057qib7 9880 23 age age NN cord-005453-4057qib7 9880 24 12,9 12,9 CD cord-005453-4057qib7 9880 25 years year NNS cord-005453-4057qib7 9880 26 ( ( -LRB- cord-005453-4057qib7 9880 27 5 5 CD cord-005453-4057qib7 9880 28 , , , cord-005453-4057qib7 9880 29 [ [ -LRB- cord-005453-4057qib7 9880 30 1 1 CD cord-005453-4057qib7 9880 31 ] ] -RRB- cord-005453-4057qib7 9880 32 [ [ -LRB- cord-005453-4057qib7 9880 33 2 2 CD cord-005453-4057qib7 9880 34 ] ] -RRB- cord-005453-4057qib7 9880 35 [ [ -LRB- cord-005453-4057qib7 9880 36 3 3 CD cord-005453-4057qib7 9880 37 ] ] -RRB- cord-005453-4057qib7 9880 38 [ [ -LRB- cord-005453-4057qib7 9880 39 4 4 CD cord-005453-4057qib7 9880 40 ] ] -RRB- cord-005453-4057qib7 9880 41 [ [ -LRB- cord-005453-4057qib7 9880 42 5 5 CD cord-005453-4057qib7 9880 43 ] ] -RRB- cord-005453-4057qib7 9880 44 [ [ -LRB- cord-005453-4057qib7 9880 45 6 6 CD cord-005453-4057qib7 9880 46 ] ] -RRB- cord-005453-4057qib7 9880 47 [ [ -LRB- cord-005453-4057qib7 9880 48 7 7 CD cord-005453-4057qib7 9880 49 ] ] -RRB- cord-005453-4057qib7 9880 50 [ [ -LRB- cord-005453-4057qib7 9880 51 8 8 CD cord-005453-4057qib7 9880 52 ] ] -RRB- cord-005453-4057qib7 9880 53 [ [ -LRB- cord-005453-4057qib7 9880 54 9 9 CD cord-005453-4057qib7 9880 55 ] ] -RRB- cord-005453-4057qib7 9880 56 [ [ -LRB- cord-005453-4057qib7 9880 57 10 10 CD cord-005453-4057qib7 9880 58 ] ] -RRB- cord-005453-4057qib7 9880 59 [ [ -LRB- cord-005453-4057qib7 9880 60 11 11 CD cord-005453-4057qib7 9880 61 ] ] -RRB- cord-005453-4057qib7 9880 62 [ [ -LRB- cord-005453-4057qib7 9880 63 12 12 CD cord-005453-4057qib7 9880 64 ] ] -RRB- cord-005453-4057qib7 9880 65 [ [ -LRB- cord-005453-4057qib7 9880 66 13 13 CD cord-005453-4057qib7 9880 67 ] ] -RRB- cord-005453-4057qib7 9880 68 [ [ -LRB- cord-005453-4057qib7 9880 69 14 14 CD cord-005453-4057qib7 9880 70 ] ] -RRB- cord-005453-4057qib7 9880 71 [ [ -LRB- cord-005453-4057qib7 9880 72 15 15 CD cord-005453-4057qib7 9880 73 ] ] -RRB- cord-005453-4057qib7 9880 74 [ [ -LRB- cord-005453-4057qib7 9880 75 16 16 CD cord-005453-4057qib7 9880 76 ] ] -RRB- cord-005453-4057qib7 9880 77 [ [ -LRB- cord-005453-4057qib7 9880 78 17 17 CD cord-005453-4057qib7 9880 79 ] ] -RRB- cord-005453-4057qib7 9880 80 [ [ -LRB- cord-005453-4057qib7 9880 81 18 18 CD cord-005453-4057qib7 9880 82 ] ] -RRB- cord-005453-4057qib7 9880 83 5 5 CD cord-005453-4057qib7 9880 84 ) ) -RRB- cord-005453-4057qib7 9880 85 . . . cord-005453-4057qib7 9881 1 Onset onset NN cord-005453-4057qib7 9881 2 of of IN cord-005453-4057qib7 9881 3 cystitis cystitis NN cord-005453-4057qib7 9881 4 occurred occur VBD cord-005453-4057qib7 9881 5 at at IN cord-005453-4057qib7 9881 6 a a DT cord-005453-4057qib7 9881 7 median median JJ cord-005453-4057qib7 9881 8 time time NN cord-005453-4057qib7 9881 9 of of IN cord-005453-4057qib7 9881 10 27 27 CD cord-005453-4057qib7 9881 11 days day NNS cord-005453-4057qib7 9881 12 ( ( -LRB- cord-005453-4057qib7 9881 13 day day NN cord-005453-4057qib7 9881 14 + + CC cord-005453-4057qib7 9881 15 -day -day : cord-005453-4057qib7 9881 16 +52 +52 NN cord-005453-4057qib7 9881 17 ) ) -RRB- cord-005453-4057qib7 9881 18 after after IN cord-005453-4057qib7 9881 19 transplantation transplantation NN cord-005453-4057qib7 9881 20 . . . cord-005453-4057qib7 9882 1 In in IN cord-005453-4057qib7 9882 2 17 17 CD cord-005453-4057qib7 9882 3 children child NNS cord-005453-4057qib7 9882 4 cystitis cystitis NN cord-005453-4057qib7 9882 5 was be VBD cord-005453-4057qib7 9882 6 severe severe JJ cord-005453-4057qib7 9882 7 . . . cord-005453-4057qib7 9883 1 The the DT cord-005453-4057qib7 9883 2 median median JJ cord-005453-4057qib7 9883 3 duration duration NN cord-005453-4057qib7 9883 4 of of IN cord-005453-4057qib7 9883 5 symptoms symptom NNS cord-005453-4057qib7 9883 6 was be VBD cord-005453-4057qib7 9883 7 27 27 CD cord-005453-4057qib7 9883 8 days day NNS cord-005453-4057qib7 9883 9 ( ( -LRB- cord-005453-4057qib7 9883 10 8 8 CD cord-005453-4057qib7 9883 11 - - SYM cord-005453-4057qib7 9883 12 200 200 CD cord-005453-4057qib7 9883 13 ) ) -RRB- cord-005453-4057qib7 9883 14 . . . cord-005453-4057qib7 9884 1 The the DT cord-005453-4057qib7 9884 2 median median JJ cord-005453-4057qib7 9884 3 time time NN cord-005453-4057qib7 9884 4 of of IN cord-005453-4057qib7 9884 5 hospitalization hospitalization NN cord-005453-4057qib7 9884 6 for for IN cord-005453-4057qib7 9884 7 children child NNS cord-005453-4057qib7 9884 8 with with IN cord-005453-4057qib7 9884 9 severe severe JJ cord-005453-4057qib7 9884 10 cystitis cystitis NN cord-005453-4057qib7 9884 11 was be VBD cord-005453-4057qib7 9884 12 70 70 CD cord-005453-4057qib7 9884 13 days day NNS cord-005453-4057qib7 9884 14 ( ( -LRB- cord-005453-4057qib7 9884 15 29 29 CD cord-005453-4057qib7 9884 16 - - SYM cord-005453-4057qib7 9884 17 242 242 CD cord-005453-4057qib7 9884 18 ) ) -RRB- cord-005453-4057qib7 9885 1 whereas whereas IN cord-005453-4057qib7 9885 2 for for IN cord-005453-4057qib7 9885 3 those those DT cord-005453-4057qib7 9885 4 who who WP cord-005453-4057qib7 9885 5 did do VBD cord-005453-4057qib7 9885 6 n't not RB cord-005453-4057qib7 9885 7 manifest manifest VB cord-005453-4057qib7 9885 8 cystitis cystitis NN cord-005453-4057qib7 9885 9 was be VBD cord-005453-4057qib7 9885 10 45 45 CD cord-005453-4057qib7 9885 11 ( ( -LRB- cord-005453-4057qib7 9885 12 25 25 CD cord-005453-4057qib7 9885 13 - - SYM cord-005453-4057qib7 9885 14 184 184 CD cord-005453-4057qib7 9885 15 ) ) -RRB- cord-005453-4057qib7 9885 16 . . . cord-005453-4057qib7 9886 1 In in IN cord-005453-4057qib7 9886 2 25 25 CD cord-005453-4057qib7 9886 3 of of IN cord-005453-4057qib7 9886 4 the the DT cord-005453-4057qib7 9886 5 37 37 CD cord-005453-4057qib7 9886 6 patients patient NNS cord-005453-4057qib7 9886 7 we -PRON- PRP cord-005453-4057qib7 9886 8 examined examine VBD cord-005453-4057qib7 9886 9 the the DT cord-005453-4057qib7 9886 10 presence presence NN cord-005453-4057qib7 9886 11 of of IN cord-005453-4057qib7 9886 12 the the DT cord-005453-4057qib7 9886 13 virus virus NN cord-005453-4057qib7 9886 14 not not RB cord-005453-4057qib7 9886 15 only only RB cord-005453-4057qib7 9886 16 in in IN cord-005453-4057qib7 9886 17 urine urine NN cord-005453-4057qib7 9886 18 but but CC cord-005453-4057qib7 9886 19 also also RB cord-005453-4057qib7 9886 20 in in IN cord-005453-4057qib7 9886 21 blood blood NN cord-005453-4057qib7 9886 22 samples sample NNS cord-005453-4057qib7 9886 23 . . . cord-005453-4057qib7 9887 1 In in IN cord-005453-4057qib7 9887 2 11 11 CD cord-005453-4057qib7 9887 3 of of IN cord-005453-4057qib7 9887 4 them -PRON- PRP cord-005453-4057qib7 9887 5 the the DT cord-005453-4057qib7 9887 6 test test NN cord-005453-4057qib7 9887 7 was be VBD cord-005453-4057qib7 9887 8 positive positive JJ cord-005453-4057qib7 9887 9 and and CC cord-005453-4057qib7 9887 10 almost almost RB cord-005453-4057qib7 9887 11 half half NN cord-005453-4057qib7 9887 12 of of IN cord-005453-4057qib7 9887 13 them -PRON- PRP cord-005453-4057qib7 9887 14 ( ( -LRB- cord-005453-4057qib7 9887 15 6 6 CD cord-005453-4057qib7 9887 16 ) ) -RRB- cord-005453-4057qib7 9887 17 manifested manifest VBD cord-005453-4057qib7 9887 18 severe severe JJ cord-005453-4057qib7 9887 19 cystitis cystitis NN cord-005453-4057qib7 9887 20 . . . cord-005453-4057qib7 9888 1 The the DT cord-005453-4057qib7 9888 2 risk risk NN cord-005453-4057qib7 9888 3 factors factor NNS cord-005453-4057qib7 9888 4 that that WDT cord-005453-4057qib7 9888 5 were be VBD cord-005453-4057qib7 9888 6 examined examine VBN cord-005453-4057qib7 9888 7 were be VBD cord-005453-4057qib7 9888 8 age age NN cord-005453-4057qib7 9888 9 , , , cord-005453-4057qib7 9888 10 administration administration NN cord-005453-4057qib7 9888 11 of of IN cord-005453-4057qib7 9888 12 antithymocyte antithymocyte NNP cord-005453-4057qib7 9888 13 globulin globulin NNP cord-005453-4057qib7 9888 14 , , , cord-005453-4057qib7 9888 15 type type NN cord-005453-4057qib7 9888 16 of of IN cord-005453-4057qib7 9888 17 disease disease NN cord-005453-4057qib7 9888 18 , , , cord-005453-4057qib7 9888 19 graft graft NN cord-005453-4057qib7 9888 20 source source NN cord-005453-4057qib7 9888 21 , , , cord-005453-4057qib7 9888 22 type type NN cord-005453-4057qib7 9888 23 of of IN cord-005453-4057qib7 9888 24 donor donor NN cord-005453-4057qib7 9888 25 and and CC cord-005453-4057qib7 9888 26 the the DT cord-005453-4057qib7 9888 27 presence presence NN cord-005453-4057qib7 9888 28 of of IN cord-005453-4057qib7 9888 29 acute acute JJ cord-005453-4057qib7 9888 30 Graft graft NN cord-005453-4057qib7 9888 31 versus versus IN cord-005453-4057qib7 9888 32 Host Host NNP cord-005453-4057qib7 9888 33 Disease Disease NNP cord-005453-4057qib7 9888 34 ( ( -LRB- cord-005453-4057qib7 9888 35 aGvHD agvhd NN cord-005453-4057qib7 9888 36 ) ) -RRB- cord-005453-4057qib7 9888 37 . . . cord-005453-4057qib7 9889 1 In in IN cord-005453-4057qib7 9889 2 multivariable multivariable JJ cord-005453-4057qib7 9889 3 analysis analysis NN cord-005453-4057qib7 9889 4 , , , cord-005453-4057qib7 9889 5 independent independent JJ cord-005453-4057qib7 9889 6 risk risk NN cord-005453-4057qib7 9889 7 factors factor NNS cord-005453-4057qib7 9889 8 for for IN cord-005453-4057qib7 9889 9 the the DT cord-005453-4057qib7 9889 10 manifestation manifestation NN cord-005453-4057qib7 9889 11 of of IN cord-005453-4057qib7 9889 12 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 9889 13 cystitis cystitis NN cord-005453-4057qib7 9889 14 were be VBD cord-005453-4057qib7 9889 15 age age NN cord-005453-4057qib7 9889 16 > > XX cord-005453-4057qib7 9889 17 6 6 CD cord-005453-4057qib7 9889 18 years year NNS cord-005453-4057qib7 9889 19 old old JJ cord-005453-4057qib7 9889 20 ( ( -LRB- cord-005453-4057qib7 9889 21 HR HR NNP cord-005453-4057qib7 9889 22 : : : cord-005453-4057qib7 9889 23 8,46 8,46 CD cord-005453-4057qib7 9889 24 , , , cord-005453-4057qib7 9889 25 95 95 CD cord-005453-4057qib7 9889 26 % % NN cord-005453-4057qib7 9889 27 CI CI NNP cord-005453-4057qib7 9889 28 , , , cord-005453-4057qib7 9889 29 2,86 2,86 CD cord-005453-4057qib7 9889 30 - - SYM cord-005453-4057qib7 9889 31 25 25 CD cord-005453-4057qib7 9889 32 , , , cord-005453-4057qib7 9889 33 p p NN cord-005453-4057qib7 9889 34 < < XX cord-005453-4057qib7 9889 35 0,001 0,001 CD cord-005453-4057qib7 9889 36 ) ) -RRB- cord-005453-4057qib7 9889 37 , , , cord-005453-4057qib7 9889 38 transplantation transplantation NN cord-005453-4057qib7 9889 39 for for IN cord-005453-4057qib7 9889 40 malignant malignant JJ cord-005453-4057qib7 9889 41 disease disease NN cord-005453-4057qib7 9889 42 ( ( -LRB- cord-005453-4057qib7 9889 43 HR hr NN cord-005453-4057qib7 9889 44 : : : cord-005453-4057qib7 9889 45 2,26 2,26 CD cord-005453-4057qib7 9889 46 , , , cord-005453-4057qib7 9889 47 95 95 CD cord-005453-4057qib7 9889 48 % % NN cord-005453-4057qib7 9889 49 CI ci NN cord-005453-4057qib7 9889 50 , , , cord-005453-4057qib7 9889 51 0,97 0,97 CD cord-005453-4057qib7 9889 52 - - HYPH cord-005453-4057qib7 9889 53 5,27 5,27 CD cord-005453-4057qib7 9889 54 , , , cord-005453-4057qib7 9889 55 P=0,05 P=0,05 NNP cord-005453-4057qib7 9889 56 ) ) -RRB- cord-005453-4057qib7 9889 57 and and CC cord-005453-4057qib7 9889 58 the the DT cord-005453-4057qib7 9889 59 presence presence NN cord-005453-4057qib7 9889 60 of of IN cord-005453-4057qib7 9889 61 aGvHD agvhd NN cord-005453-4057qib7 9889 62 ( ( -LRB- cord-005453-4057qib7 9889 63 HR HR NNP cord-005453-4057qib7 9889 64 : : : cord-005453-4057qib7 9889 65 4,04 4,04 CD cord-005453-4057qib7 9889 66 , , , cord-005453-4057qib7 9889 67 95 95 CD cord-005453-4057qib7 9889 68 % % NN cord-005453-4057qib7 9889 69 CI ci NN cord-005453-4057qib7 9889 70 , , , cord-005453-4057qib7 9889 71 2,01 2,01 CD cord-005453-4057qib7 9889 72 - - SYM cord-005453-4057qib7 9889 73 8,1 8,1 NN cord-005453-4057qib7 9889 74 , , , cord-005453-4057qib7 9889 75 P p NN cord-005453-4057qib7 9889 76 < < XX cord-005453-4057qib7 9889 77 0,001 0,001 CD cord-005453-4057qib7 9889 78 ) ) -RRB- cord-005453-4057qib7 9889 79 . . . cord-005453-4057qib7 9890 1 The the DT cord-005453-4057qib7 9890 2 overall overall JJ cord-005453-4057qib7 9890 3 survival survival NN cord-005453-4057qib7 9890 4 of of IN cord-005453-4057qib7 9890 5 children child NNS cord-005453-4057qib7 9890 6 with with IN cord-005453-4057qib7 9890 7 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 9890 8 cystitis cystitis NN cord-005453-4057qib7 9890 9 was be VBD cord-005453-4057qib7 9890 10 46,3 46,3 CD cord-005453-4057qib7 9890 11 % % NN cord-005453-4057qib7 9890 12 vs vs IN cord-005453-4057qib7 9890 13 69,3 69,3 CD cord-005453-4057qib7 9890 14 % % NN cord-005453-4057qib7 9890 15 of of IN cord-005453-4057qib7 9890 16 those those DT cord-005453-4057qib7 9890 17 who who WP cord-005453-4057qib7 9890 18 did do VBD cord-005453-4057qib7 9890 19 n't not RB cord-005453-4057qib7 9890 20 manifest manifest VB cord-005453-4057qib7 9890 21 this this DT cord-005453-4057qib7 9890 22 complication complication NN cord-005453-4057qib7 9890 23 , , , cord-005453-4057qib7 9890 24 but but CC cord-005453-4057qib7 9890 25 in in IN cord-005453-4057qib7 9890 26 multivariable multivariable JJ cord-005453-4057qib7 9890 27 analysis analysis NN cord-005453-4057qib7 9890 28 for for IN cord-005453-4057qib7 9890 29 survival survival NN cord-005453-4057qib7 9890 30 cystitis cystitis NNP cord-005453-4057qib7 9890 31 was be VBD cord-005453-4057qib7 9890 32 n't not RB cord-005453-4057qib7 9890 33 a a DT cord-005453-4057qib7 9890 34 statistically statistically RB cord-005453-4057qib7 9890 35 significant significant JJ cord-005453-4057qib7 9890 36 risk risk NN cord-005453-4057qib7 9890 37 factor factor NN cord-005453-4057qib7 9890 38 . . . cord-005453-4057qib7 9891 1 Conclusions conclusion NNS cord-005453-4057qib7 9891 2 : : : cord-005453-4057qib7 9892 1 According accord VBG cord-005453-4057qib7 9892 2 to to IN cord-005453-4057qib7 9892 3 our -PRON- PRP$ cord-005453-4057qib7 9892 4 results result NNS cord-005453-4057qib7 9892 5 , , , cord-005453-4057qib7 9892 6 stem stem NN cord-005453-4057qib7 9892 7 cell cell NN cord-005453-4057qib7 9892 8 transplantation transplantation NN cord-005453-4057qib7 9892 9 in in IN cord-005453-4057qib7 9892 10 children child NNS cord-005453-4057qib7 9892 11 > > XX cord-005453-4057qib7 9892 12 6 6 CD cord-005453-4057qib7 9892 13 years year NNS cord-005453-4057qib7 9892 14 old old JJ cord-005453-4057qib7 9892 15 who who WP cord-005453-4057qib7 9892 16 suffer suffer VBP cord-005453-4057qib7 9892 17 from from IN cord-005453-4057qib7 9892 18 a a DT cord-005453-4057qib7 9892 19 malignant malignant JJ cord-005453-4057qib7 9892 20 disease disease NN cord-005453-4057qib7 9892 21 and and CC cord-005453-4057qib7 9892 22 the the DT cord-005453-4057qib7 9892 23 presence presence NN cord-005453-4057qib7 9892 24 of of IN cord-005453-4057qib7 9892 25 aGvHD aGvHD NNP cord-005453-4057qib7 9892 26 consist consist VBP cord-005453-4057qib7 9892 27 independent independent JJ cord-005453-4057qib7 9892 28 risk risk NN cord-005453-4057qib7 9892 29 factors factor NNS cord-005453-4057qib7 9892 30 for for IN cord-005453-4057qib7 9892 31 the the DT cord-005453-4057qib7 9892 32 manifestation manifestation NN cord-005453-4057qib7 9892 33 of of IN cord-005453-4057qib7 9892 34 BK BK NNP cord-005453-4057qib7 9892 35 virus virus NN cord-005453-4057qib7 9892 36 associated associate VBD cord-005453-4057qib7 9892 37 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 9892 38 cystitis cystitis NN cord-005453-4057qib7 9892 39 . . . cord-005453-4057qib7 9893 1 The the DT cord-005453-4057qib7 9893 2 identification identification NN cord-005453-4057qib7 9893 3 of of IN cord-005453-4057qib7 9893 4 the the DT cord-005453-4057qib7 9893 5 risk risk NN cord-005453-4057qib7 9893 6 factors factor NNS cord-005453-4057qib7 9893 7 of of IN cord-005453-4057qib7 9893 8 this this DT cord-005453-4057qib7 9893 9 serious serious JJ cord-005453-4057qib7 9893 10 complication complication NN cord-005453-4057qib7 9893 11 will will MD cord-005453-4057qib7 9893 12 contribute contribute VB cord-005453-4057qib7 9893 13 to to IN cord-005453-4057qib7 9893 14 better well JJR cord-005453-4057qib7 9893 15 management management NN cord-005453-4057qib7 9893 16 of of IN cord-005453-4057qib7 9893 17 transplanted transplanted JJ cord-005453-4057qib7 9893 18 patients patient NNS cord-005453-4057qib7 9893 19 . . . cord-005453-4057qib7 9894 1 Further further JJ cord-005453-4057qib7 9894 2 research research NN cord-005453-4057qib7 9894 3 through through IN cord-005453-4057qib7 9894 4 prospective prospective JJ cord-005453-4057qib7 9894 5 trials trial NNS cord-005453-4057qib7 9894 6 can can MD cord-005453-4057qib7 9894 7 contribute contribute VB cord-005453-4057qib7 9894 8 to to IN cord-005453-4057qib7 9894 9 the the DT cord-005453-4057qib7 9894 10 better well JJR cord-005453-4057qib7 9894 11 understanding understanding NN cord-005453-4057qib7 9894 12 of of IN cord-005453-4057qib7 9894 13 the the DT cord-005453-4057qib7 9894 14 pathophysiology pathophysiology NN cord-005453-4057qib7 9894 15 of of IN cord-005453-4057qib7 9894 16 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 9894 17 cystitis cystitis NN cord-005453-4057qib7 9894 18 and and CC cord-005453-4057qib7 9894 19 to to IN cord-005453-4057qib7 9894 20 the the DT cord-005453-4057qib7 9894 21 establishment establishment NN cord-005453-4057qib7 9894 22 of of IN cord-005453-4057qib7 9894 23 appropriate appropriate JJ cord-005453-4057qib7 9894 24 diagnostic diagnostic JJ cord-005453-4057qib7 9894 25 and and CC cord-005453-4057qib7 9894 26 therapeutic therapeutic JJ cord-005453-4057qib7 9894 27 guidelines guideline NNS cord-005453-4057qib7 9894 28 . . . cord-005453-4057qib7 9895 1 Disclosure disclosure NN cord-005453-4057qib7 9895 2 : : : cord-005453-4057qib7 9895 3 Nothing nothing NN cord-005453-4057qib7 9895 4 to to TO cord-005453-4057qib7 9895 5 declare declare VB cord-005453-4057qib7 9895 6 P442 P442 NNP cord-005453-4057qib7 9895 7 Impact Impact NNP cord-005453-4057qib7 9895 8 of of IN cord-005453-4057qib7 9895 9 natural natural JJ cord-005453-4057qib7 9895 10 killer killer NN cord-005453-4057qib7 9895 11 cell cell NN cord-005453-4057qib7 9895 12 reconstitution reconstitution NN cord-005453-4057qib7 9895 13 on on IN cord-005453-4057qib7 9895 14 outcomes outcome NNS cord-005453-4057qib7 9895 15 in in IN cord-005453-4057qib7 9895 16 patients patient NNS cord-005453-4057qib7 9895 17 with with IN cord-005453-4057qib7 9895 18 early early JJ cord-005453-4057qib7 9895 19 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 9895 20 reactivation reactivation NN cord-005453-4057qib7 9895 21 after after IN cord-005453-4057qib7 9895 22 allogeneic allogeneic NN cord-005453-4057qib7 9895 23 hematopoietic hematopoietic JJ cord-005453-4057qib7 9895 24 stem stem NN cord-005453-4057qib7 9895 25 cell cell NN cord-005453-4057qib7 9895 26 transplantation transplantation NN cord-005453-4057qib7 9895 27 Background background NN cord-005453-4057qib7 9895 28 : : : cord-005453-4057qib7 9896 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 9896 2 ( ( -LRB- cord-005453-4057qib7 9896 3 CMV CMV NNP cord-005453-4057qib7 9896 4 ) ) -RRB- cord-005453-4057qib7 9896 5 reactivation reactivation NN cord-005453-4057qib7 9896 6 influences influence VBZ cord-005453-4057qib7 9896 7 survival survival NN cord-005453-4057qib7 9896 8 after after IN cord-005453-4057qib7 9896 9 allogeneic allogeneic JJ cord-005453-4057qib7 9896 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 9896 11 stem stem NN cord-005453-4057qib7 9896 12 cell cell NN cord-005453-4057qib7 9896 13 transplantation transplantation NN cord-005453-4057qib7 9896 14 ( ( -LRB- cord-005453-4057qib7 9896 15 SCT SCT NNP cord-005453-4057qib7 9896 16 ) ) -RRB- cord-005453-4057qib7 9896 17 and and CC cord-005453-4057qib7 9896 18 induces induce VBZ cord-005453-4057qib7 9896 19 natural natural JJ cord-005453-4057qib7 9896 20 killer killer NN cord-005453-4057qib7 9896 21 ( ( -LRB- cord-005453-4057qib7 9896 22 NK NK NNP cord-005453-4057qib7 9896 23 ) ) -RRB- cord-005453-4057qib7 9896 24 cell cell NN cord-005453-4057qib7 9896 25 expansion expansion NN cord-005453-4057qib7 9896 26 . . . cord-005453-4057qib7 9897 1 We -PRON- PRP cord-005453-4057qib7 9897 2 evaluated evaluate VBD cord-005453-4057qib7 9897 3 NK NK NNP cord-005453-4057qib7 9897 4 cell cell NN cord-005453-4057qib7 9897 5 reconstitution reconstitution NN cord-005453-4057qib7 9897 6 and and CC cord-005453-4057qib7 9897 7 clinical clinical JJ cord-005453-4057qib7 9897 8 outcomes outcome NNS cord-005453-4057qib7 9897 9 following follow VBG cord-005453-4057qib7 9897 10 early early JJ cord-005453-4057qib7 9897 11 CMV CMV NNP cord-005453-4057qib7 9897 12 reactivation reactivation NN cord-005453-4057qib7 9897 13 after after IN cord-005453-4057qib7 9897 14 SCT SCT NNP cord-005453-4057qib7 9897 15 . . . cord-005453-4057qib7 9898 1 Methods method NNS cord-005453-4057qib7 9898 2 : : : cord-005453-4057qib7 9899 1 Lymphocyte lymphocyte NN cord-005453-4057qib7 9899 2 subsets subset NNS cord-005453-4057qib7 9899 3 were be VBD cord-005453-4057qib7 9899 4 measured measure VBN cord-005453-4057qib7 9899 5 by by IN cord-005453-4057qib7 9899 6 flow flow NN cord-005453-4057qib7 9899 7 cytometry cytometry NN cord-005453-4057qib7 9899 8 on on IN cord-005453-4057qib7 9899 9 day day NN cord-005453-4057qib7 9899 10 100 100 CD cord-005453-4057qib7 9899 11 in in IN cord-005453-4057qib7 9899 12 patients patient NNS cord-005453-4057qib7 9899 13 with with IN cord-005453-4057qib7 9899 14 hematologic hematologic JJ cord-005453-4057qib7 9899 15 malignancies malignancy NNS cord-005453-4057qib7 9899 16 undergoing undergo VBG cord-005453-4057qib7 9899 17 SCT SCT NNP cord-005453-4057qib7 9899 18 between between IN cord-005453-4057qib7 9899 19 January January NNP cord-005453-4057qib7 9899 20 2009 2009 CD cord-005453-4057qib7 9899 21 and and CC cord-005453-4057qib7 9899 22 December December NNP cord-005453-4057qib7 9899 23 2017 2017 CD cord-005453-4057qib7 9899 24 at at IN cord-005453-4057qib7 9899 25 Kanagawa Kanagawa NNP cord-005453-4057qib7 9899 26 Cancer Cancer NNP cord-005453-4057qib7 9899 27 Center Center NNP cord-005453-4057qib7 9899 28 , , , cord-005453-4057qib7 9899 29 excluding exclude VBG cord-005453-4057qib7 9899 30 patients patient NNS cord-005453-4057qib7 9899 31 with with IN cord-005453-4057qib7 9899 32 graft graft NN cord-005453-4057qib7 9899 33 failure failure NN cord-005453-4057qib7 9899 34 or or CC cord-005453-4057qib7 9899 35 death death NN cord-005453-4057qib7 9899 36 within within IN cord-005453-4057qib7 9899 37 100 100 CD cord-005453-4057qib7 9899 38 days day NNS cord-005453-4057qib7 9899 39 . . . cord-005453-4057qib7 9900 1 CMV CMV NNP cord-005453-4057qib7 9900 2 reactivation reactivation NN cord-005453-4057qib7 9900 3 was be VBD cord-005453-4057qib7 9900 4 defined define VBN cord-005453-4057qib7 9900 5 as as IN cord-005453-4057qib7 9900 6 initiation initiation NN cord-005453-4057qib7 9900 7 of of IN cord-005453-4057qib7 9900 8 preemptive preemptive JJ cord-005453-4057qib7 9900 9 CMV CMV NNP cord-005453-4057qib7 9900 10 therapy therapy NN cord-005453-4057qib7 9900 11 following follow VBG cord-005453-4057qib7 9900 12 pp65 pp65 NNP cord-005453-4057qib7 9900 13 antigenemia antigenemia NNP cord-005453-4057qib7 9900 14 surveillance surveillance NN cord-005453-4057qib7 9900 15 . . . cord-005453-4057qib7 9901 1 Results result NNS cord-005453-4057qib7 9901 2 : : : cord-005453-4057qib7 9902 1 The the DT cord-005453-4057qib7 9902 2 subjects subject NNS cord-005453-4057qib7 9902 3 were be VBD cord-005453-4057qib7 9902 4 152 152 CD cord-005453-4057qib7 9902 5 males male NNS cord-005453-4057qib7 9902 6 and and CC cord-005453-4057qib7 9902 7 94 94 CD cord-005453-4057qib7 9902 8 females female NNS cord-005453-4057qib7 9902 9 with with IN cord-005453-4057qib7 9902 10 a a DT cord-005453-4057qib7 9902 11 median median JJ cord-005453-4057qib7 9902 12 age age NN cord-005453-4057qib7 9902 13 of of IN cord-005453-4057qib7 9902 14 51 51 CD cord-005453-4057qib7 9902 15 years year NNS cord-005453-4057qib7 9903 1 ( ( -LRB- cord-005453-4057qib7 9903 2 range range NN cord-005453-4057qib7 9903 3 : : : cord-005453-4057qib7 9903 4 18 18 CD cord-005453-4057qib7 9903 5 - - SYM cord-005453-4057qib7 9903 6 69 69 CD cord-005453-4057qib7 9903 7 years year NNS cord-005453-4057qib7 9903 8 ) ) -RRB- cord-005453-4057qib7 9903 9 . . . cord-005453-4057qib7 9904 1 The the DT cord-005453-4057qib7 9904 2 median median JJ cord-005453-4057qib7 9904 3 follow follow NN cord-005453-4057qib7 9904 4 - - HYPH cord-005453-4057qib7 9904 5 up up NN cord-005453-4057qib7 9904 6 period period NN cord-005453-4057qib7 9904 7 for for IN cord-005453-4057qib7 9904 8 survivors survivor NNS cord-005453-4057qib7 9904 9 was be VBD cord-005453-4057qib7 9904 10 3.2 3.2 CD cord-005453-4057qib7 9904 11 years year NNS cord-005453-4057qib7 9904 12 ( ( -LRB- cord-005453-4057qib7 9904 13 range range NN cord-005453-4057qib7 9904 14 : : : cord-005453-4057qib7 9904 15 0.8 0.8 CD cord-005453-4057qib7 9904 16 - - HYPH cord-005453-4057qib7 9904 17 9.6 9.6 CD cord-005453-4057qib7 9904 18 years year NNS cord-005453-4057qib7 9904 19 ) ) -RRB- cord-005453-4057qib7 9904 20 . . . cord-005453-4057qib7 9905 1 There there EX cord-005453-4057qib7 9905 2 were be VBD cord-005453-4057qib7 9905 3 128 128 CD cord-005453-4057qib7 9905 4 patients patient NNS cord-005453-4057qib7 9905 5 with with IN cord-005453-4057qib7 9905 6 acute acute JJ cord-005453-4057qib7 9905 7 myeloid myeloid NN cord-005453-4057qib7 9905 8 leukemia leukemia NN cord-005453-4057qib7 9905 9 , , , cord-005453-4057qib7 9905 10 64 64 CD cord-005453-4057qib7 9905 11 with with IN cord-005453-4057qib7 9905 12 acute acute JJ cord-005453-4057qib7 9905 13 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 9905 14 leukemia leukemia NN cord-005453-4057qib7 9905 15 , , , cord-005453-4057qib7 9905 16 32 32 CD cord-005453-4057qib7 9905 17 with with IN cord-005453-4057qib7 9905 18 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 9905 19 syndromes syndrome NNS cord-005453-4057qib7 9905 20 , , , cord-005453-4057qib7 9905 21 and and CC cord-005453-4057qib7 9905 22 22 22 CD cord-005453-4057qib7 9905 23 with with IN cord-005453-4057qib7 9905 24 other other JJ cord-005453-4057qib7 9905 25 diseases disease NNS cord-005453-4057qib7 9905 26 . . . cord-005453-4057qib7 9906 1 At at IN cord-005453-4057qib7 9906 2 transplantation transplantation NN cord-005453-4057qib7 9906 3 , , , cord-005453-4057qib7 9906 4 166 166 CD cord-005453-4057qib7 9906 5 patients patient NNS cord-005453-4057qib7 9906 6 were be VBD cord-005453-4057qib7 9906 7 standard standard JJ cord-005453-4057qib7 9906 8 risk risk NN cord-005453-4057qib7 9906 9 and and CC cord-005453-4057qib7 9906 10 80 80 CD cord-005453-4057qib7 9906 11 were be VBD cord-005453-4057qib7 9906 12 high high JJ cord-005453-4057qib7 9906 13 risk risk NN cord-005453-4057qib7 9906 14 . . . cord-005453-4057qib7 9907 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 9907 2 conditioning conditioning NN cord-005453-4057qib7 9907 3 and and CC cord-005453-4057qib7 9907 4 reduced reduce VBN cord-005453-4057qib7 9907 5 - - HYPH cord-005453-4057qib7 9907 6 intensity intensity NN cord-005453-4057qib7 9907 7 conditioning conditioning NN cord-005453-4057qib7 9907 8 were be VBD cord-005453-4057qib7 9907 9 employed employ VBN cord-005453-4057qib7 9907 10 in in IN cord-005453-4057qib7 9907 11 99 99 CD cord-005453-4057qib7 9907 12 and and CC cord-005453-4057qib7 9907 13 147 147 CD cord-005453-4057qib7 9907 14 patients patient NNS cord-005453-4057qib7 9907 15 , , , cord-005453-4057qib7 9907 16 respectively respectively RB cord-005453-4057qib7 9907 17 . . . cord-005453-4057qib7 9908 1 Bone bone NN cord-005453-4057qib7 9908 2 marrow marrow NN cord-005453-4057qib7 9908 3 transplantation transplantation NN cord-005453-4057qib7 9908 4 , , , cord-005453-4057qib7 9908 5 peripheral peripheral JJ cord-005453-4057qib7 9908 6 blood blood NN cord-005453-4057qib7 9908 7 stem stem NN cord-005453-4057qib7 9908 8 cell cell NN cord-005453-4057qib7 9908 9 transplantation transplantation NN cord-005453-4057qib7 9908 10 , , , cord-005453-4057qib7 9908 11 and and CC cord-005453-4057qib7 9908 12 cord cord NN cord-005453-4057qib7 9908 13 blood blood NN cord-005453-4057qib7 9908 14 transplantation transplantation NN cord-005453-4057qib7 9908 15 was be VBD cord-005453-4057qib7 9908 16 performed perform VBN cord-005453-4057qib7 9908 17 in in IN cord-005453-4057qib7 9908 18 98 98 CD cord-005453-4057qib7 9908 19 , , , cord-005453-4057qib7 9908 20 36 36 CD cord-005453-4057qib7 9908 21 , , , cord-005453-4057qib7 9908 22 and and CC cord-005453-4057qib7 9908 23 112 112 CD cord-005453-4057qib7 9908 24 patients patient NNS cord-005453-4057qib7 9908 25 , , , cord-005453-4057qib7 9908 26 respectively respectively RB cord-005453-4057qib7 9908 27 . . . cord-005453-4057qib7 9909 1 CMV CMV NNP cord-005453-4057qib7 9909 2 reactivation reactivation NN cord-005453-4057qib7 9909 3 occurred occur VBD cord-005453-4057qib7 9909 4 in in IN cord-005453-4057qib7 9909 5 141 141 CD cord-005453-4057qib7 9909 6 patients patient NNS cord-005453-4057qib7 9909 7 ( ( -LRB- cord-005453-4057qib7 9909 8 57 57 CD cord-005453-4057qib7 9909 9 % % NN cord-005453-4057qib7 9909 10 ) ) -RRB- cord-005453-4057qib7 9909 11 at at IN cord-005453-4057qib7 9909 12 a a DT cord-005453-4057qib7 9909 13 median median NN cord-005453-4057qib7 9909 14 of of IN cord-005453-4057qib7 9909 15 45 45 CD cord-005453-4057qib7 9909 16 days day NNS cord-005453-4057qib7 9909 17 ( ( -LRB- cord-005453-4057qib7 9909 18 range range NN cord-005453-4057qib7 9909 19 : : : cord-005453-4057qib7 9909 20 15 15 CD cord-005453-4057qib7 9909 21 - - SYM cord-005453-4057qib7 9909 22 93 93 CD cord-005453-4057qib7 9909 23 days day NNS cord-005453-4057qib7 9909 24 ) ) -RRB- cord-005453-4057qib7 9909 25 after after IN cord-005453-4057qib7 9909 26 SCT SCT NNP cord-005453-4057qib7 9909 27 . . . cord-005453-4057qib7 9910 1 Grade Grade NNP cord-005453-4057qib7 9910 2 II II NNP cord-005453-4057qib7 9910 3 - - HYPH cord-005453-4057qib7 9910 4 IV IV NNP cord-005453-4057qib7 9910 5 acute acute JJ cord-005453-4057qib7 9910 6 GVHD GVHD NNP cord-005453-4057qib7 9910 7 and and CC cord-005453-4057qib7 9910 8 chronic chronic JJ cord-005453-4057qib7 9910 9 GVHD GVHD NNP cord-005453-4057qib7 9910 10 affected affect VBD cord-005453-4057qib7 9910 11 89 89 CD cord-005453-4057qib7 9910 12 patients patient NNS cord-005453-4057qib7 9910 13 ( ( -LRB- cord-005453-4057qib7 9910 14 36 36 CD cord-005453-4057qib7 9910 15 % % NN cord-005453-4057qib7 9910 16 ) ) -RRB- cord-005453-4057qib7 9910 17 and and CC cord-005453-4057qib7 9910 18 80 80 CD cord-005453-4057qib7 9910 19 patients patient NNS cord-005453-4057qib7 9910 20 ( ( -LRB- cord-005453-4057qib7 9910 21 33 33 CD cord-005453-4057qib7 9910 22 % % NN cord-005453-4057qib7 9910 23 ) ) -RRB- cord-005453-4057qib7 9910 24 , , , cord-005453-4057qib7 9910 25 respectively respectively RB cord-005453-4057qib7 9910 26 . . . cord-005453-4057qib7 9911 1 Among among IN cord-005453-4057qib7 9911 2 all all DT cord-005453-4057qib7 9911 3 patients patient NNS cord-005453-4057qib7 9911 4 , , , cord-005453-4057qib7 9911 5 5-year 5-year CD cord-005453-4057qib7 9911 6 overall overall JJ cord-005453-4057qib7 9911 7 survival survival NN cord-005453-4057qib7 9911 8 ( ( -LRB- cord-005453-4057qib7 9911 9 OS OS NNP cord-005453-4057qib7 9911 10 ) ) -RRB- cord-005453-4057qib7 9911 11 , , , cord-005453-4057qib7 9911 12 cumulative cumulative JJ cord-005453-4057qib7 9911 13 nonrelapse nonrelapse JJ cord-005453-4057qib7 9911 14 mortality mortality NN cord-005453-4057qib7 9911 15 ( ( -LRB- cord-005453-4057qib7 9911 16 NRM NRM NNP cord-005453-4057qib7 9911 17 ) ) -RRB- cord-005453-4057qib7 9911 18 , , , cord-005453-4057qib7 9911 19 and and CC cord-005453-4057qib7 9911 20 cumulative cumulative JJ cord-005453-4057qib7 9911 21 relapse relapse NN cord-005453-4057qib7 9911 22 ( ( -LRB- cord-005453-4057qib7 9911 23 CIR CIR NNP cord-005453-4057qib7 9911 24 ) ) -RRB- cord-005453-4057qib7 9911 25 rates rate NNS cord-005453-4057qib7 9911 26 were be VBD cord-005453-4057qib7 9911 27 66 66 CD cord-005453-4057qib7 9911 28 % % NN cord-005453-4057qib7 9911 29 , , , cord-005453-4057qib7 9911 30 10 10 CD cord-005453-4057qib7 9911 31 % % NN cord-005453-4057qib7 9911 32 , , , cord-005453-4057qib7 9911 33 and and CC cord-005453-4057qib7 9911 34 33 33 CD cord-005453-4057qib7 9911 35 % % NN cord-005453-4057qib7 9911 36 , , , cord-005453-4057qib7 9911 37 respectively respectively RB cord-005453-4057qib7 9911 38 . . . cord-005453-4057qib7 9912 1 In in IN cord-005453-4057qib7 9912 2 patients patient NNS cord-005453-4057qib7 9912 3 without without IN cord-005453-4057qib7 9912 4 CMV CMV NNP cord-005453-4057qib7 9912 5 reactivation reactivation NN cord-005453-4057qib7 9912 6 ( ( -LRB- cord-005453-4057qib7 9912 7 CMVR- CMVR- NNP cord-005453-4057qib7 9912 8 ) ) -RRB- cord-005453-4057qib7 9912 9 versus versus IN cord-005453-4057qib7 9912 10 patients patient NNS cord-005453-4057qib7 9912 11 with with IN cord-005453-4057qib7 9912 12 CMV CMV NNP cord-005453-4057qib7 9912 13 reactivation reactivation NN cord-005453-4057qib7 9912 14 ( ( -LRB- cord-005453-4057qib7 9912 15 CMVR+ CMVR+ NNP cord-005453-4057qib7 9912 16 ) ) -RRB- cord-005453-4057qib7 9912 17 , , . cord-005453-4057qib7 9913 1 5-year 5-year CD cord-005453-4057qib7 9913 2 OS OS NNP cord-005453-4057qib7 9913 3 , , , cord-005453-4057qib7 9913 4 NRM NRM NNP cord-005453-4057qib7 9913 5 , , , cord-005453-4057qib7 9913 6 and and CC cord-005453-4057qib7 9913 7 CIR CIR NNP cord-005453-4057qib7 9913 8 were be VBD cord-005453-4057qib7 9913 9 79 79 CD cord-005453-4057qib7 9913 10 % % NN cord-005453-4057qib7 9913 11 vs. vs. IN cord-005453-4057qib7 9913 12 55 55 CD cord-005453-4057qib7 9913 13 % % NN cord-005453-4057qib7 9914 1 ( ( -LRB- cord-005453-4057qib7 9914 2 p p NN cord-005453-4057qib7 9914 3 < < XX cord-005453-4057qib7 9914 4 0.001 0.001 CD cord-005453-4057qib7 9914 5 ) ) -RRB- cord-005453-4057qib7 9914 6 , , , cord-005453-4057qib7 9914 7 3 3 CD cord-005453-4057qib7 9914 8 % % NN cord-005453-4057qib7 9914 9 vs. vs. CC cord-005453-4057qib7 9914 10 16 16 CD cord-005453-4057qib7 9914 11 % % NN cord-005453-4057qib7 9914 12 ( ( -LRB- cord-005453-4057qib7 9914 13 p p NN cord-005453-4057qib7 9914 14 = = SYM cord-005453-4057qib7 9914 15 0.005 0.005 CD cord-005453-4057qib7 9914 16 ) ) -RRB- cord-005453-4057qib7 9914 17 , , , cord-005453-4057qib7 9914 18 and and CC cord-005453-4057qib7 9914 19 27 27 CD cord-005453-4057qib7 9914 20 % % NN cord-005453-4057qib7 9914 21 vs. vs. IN cord-005453-4057qib7 9914 22 38 38 CD cord-005453-4057qib7 9914 23 % % NN cord-005453-4057qib7 9914 24 ( ( -LRB- cord-005453-4057qib7 9914 25 p p NN cord-005453-4057qib7 9914 26 = = SYM cord-005453-4057qib7 9914 27 0.142 0.142 CD cord-005453-4057qib7 9914 28 ) ) -RRB- cord-005453-4057qib7 9914 29 , , , cord-005453-4057qib7 9914 30 respectively respectively RB cord-005453-4057qib7 9914 31 . . . cord-005453-4057qib7 9915 1 Among among IN cord-005453-4057qib7 9915 2 all all DT cord-005453-4057qib7 9915 3 patients patient NNS cord-005453-4057qib7 9915 4 , , , cord-005453-4057qib7 9915 5 the the DT cord-005453-4057qib7 9915 6 median median JJ cord-005453-4057qib7 9915 7 level level NN cord-005453-4057qib7 9915 8 of of IN cord-005453-4057qib7 9915 9 CD3-CD56 cd3-cd56 NN cord-005453-4057qib7 9915 10 + + CC cord-005453-4057qib7 9915 11 cells cell NNS cord-005453-4057qib7 9915 12 , , , cord-005453-4057qib7 9916 1 CD16 CD16 NNP cord-005453-4057qib7 9916 2 + + SYM cord-005453-4057qib7 9916 3 CD57cells CD57cells NNP cord-005453-4057qib7 9916 4 , , , cord-005453-4057qib7 9916 5 and and CC cord-005453-4057qib7 9916 6 CD16+CD57 CD16+CD57 NNP cord-005453-4057qib7 9916 7 + + CC cord-005453-4057qib7 9916 8 cells cell NNS cord-005453-4057qib7 9916 9 on on IN cord-005453-4057qib7 9916 10 day day NN cord-005453-4057qib7 9916 11 100 100 CD cord-005453-4057qib7 9916 12 was be VBD cord-005453-4057qib7 9916 13 236/ 236/ CD cord-005453-4057qib7 9917 1 μl μl IN cord-005453-4057qib7 9918 1 ( ( -LRB- cord-005453-4057qib7 9918 2 range range NN cord-005453-4057qib7 9918 3 : : : cord-005453-4057qib7 9918 4 19 19 CD cord-005453-4057qib7 9918 5 - - SYM cord-005453-4057qib7 9918 6 2150 2150 CD cord-005453-4057qib7 9918 7 / / SYM cord-005453-4057qib7 9918 8 μl μl NN cord-005453-4057qib7 9918 9 ) ) -RRB- cord-005453-4057qib7 9918 10 , , . cord-005453-4057qib7 9919 1 275 275 CD cord-005453-4057qib7 9919 2 / / SYM cord-005453-4057qib7 9919 3 μl μl NN cord-005453-4057qib7 9919 4 ( ( -LRB- cord-005453-4057qib7 9919 5 9 9 CD cord-005453-4057qib7 9919 6 - - SYM cord-005453-4057qib7 9919 7 2660 2660 CD cord-005453-4057qib7 9919 8 / / SYM cord-005453-4057qib7 9919 9 μl μl NN cord-005453-4057qib7 9919 10 ) ) -RRB- cord-005453-4057qib7 9919 11 , , , cord-005453-4057qib7 9919 12 and and CC cord-005453-4057qib7 9919 13 98 98 CD cord-005453-4057qib7 9919 14 / / SYM cord-005453-4057qib7 9919 15 μl μl NN cord-005453-4057qib7 9919 16 ( ( -LRB- cord-005453-4057qib7 9919 17 3 3 CD cord-005453-4057qib7 9919 18 - - SYM cord-005453-4057qib7 9919 19 1767 1767 CD cord-005453-4057qib7 9919 20 / / SYM cord-005453-4057qib7 9919 21 μl μl NN cord-005453-4057qib7 9919 22 ) ) -RRB- cord-005453-4057qib7 9919 23 , , , cord-005453-4057qib7 9919 24 respectively respectively RB cord-005453-4057qib7 9919 25 . . . cord-005453-4057qib7 9920 1 NK NK NNP cord-005453-4057qib7 9920 2 cell cell NN cord-005453-4057qib7 9920 3 subsets subset NNS cord-005453-4057qib7 9920 4 showed show VBD cord-005453-4057qib7 9920 5 no no DT cord-005453-4057qib7 9920 6 significant significant JJ cord-005453-4057qib7 9920 7 differences difference NNS cord-005453-4057qib7 9920 8 between between IN cord-005453-4057qib7 9920 9 CMVR CMVR NNP cord-005453-4057qib7 9920 10 - - : cord-005453-4057qib7 9920 11 and and CC cord-005453-4057qib7 9920 12 CMVR+ CMVR+ NNP cord-005453-4057qib7 9920 13 patients patient NNS cord-005453-4057qib7 9920 14 . . . cord-005453-4057qib7 9921 1 When when WRB cord-005453-4057qib7 9921 2 patients patient NNS cord-005453-4057qib7 9921 3 were be VBD cord-005453-4057qib7 9921 4 divided divide VBN cord-005453-4057qib7 9921 5 into into IN cord-005453-4057qib7 9921 6 low low JJ cord-005453-4057qib7 9921 7 and and CC cord-005453-4057qib7 9921 8 high high JJ cord-005453-4057qib7 9921 9 groups group NNS cord-005453-4057qib7 9921 10 at at IN cord-005453-4057qib7 9921 11 the the DT cord-005453-4057qib7 9921 12 median median JJ cord-005453-4057qib7 9921 13 level level NN cord-005453-4057qib7 9921 14 of of IN cord-005453-4057qib7 9921 15 each each DT cord-005453-4057qib7 9921 16 NK NK NNP cord-005453-4057qib7 9921 17 cell cell NN cord-005453-4057qib7 9921 18 subset subset VBN cord-005453-4057qib7 9921 19 , , , cord-005453-4057qib7 9921 20 CMVR+ CMVR+ NNP cord-005453-4057qib7 9921 21 patients patient NNS cord-005453-4057qib7 9921 22 with with IN cord-005453-4057qib7 9921 23 high high JJ cord-005453-4057qib7 9921 24 CD3-CD56 cd3-cd56 NN cord-005453-4057qib7 9922 1 + + UH cord-005453-4057qib7 9922 2 , , , cord-005453-4057qib7 9922 3 CD16+CD57- CD16+CD57- NNP cord-005453-4057qib7 9922 4 , , , cord-005453-4057qib7 9922 5 or or CC cord-005453-4057qib7 9922 6 CD16+CD57 CD16+CD57 NNP cord-005453-4057qib7 9922 7 + + CC cord-005453-4057qib7 9922 8 cells cell NNS cord-005453-4057qib7 9922 9 showed show VBD cord-005453-4057qib7 9922 10 significantly significantly RB cord-005453-4057qib7 9922 11 better well JJR cord-005453-4057qib7 9922 12 5-year 5-year CD cord-005453-4057qib7 9922 13 OS os NN cord-005453-4057qib7 9922 14 than than IN cord-005453-4057qib7 9922 15 those those DT cord-005453-4057qib7 9922 16 with with IN cord-005453-4057qib7 9922 17 low low JJ cord-005453-4057qib7 9922 18 cells cell NNS cord-005453-4057qib7 9922 19 ( ( -LRB- cord-005453-4057qib7 9922 20 72 72 CD cord-005453-4057qib7 9922 21 % % NN cord-005453-4057qib7 9922 22 vs. vs. CC cord-005453-4057qib7 9922 23 35 35 CD cord-005453-4057qib7 9922 24 % % NN cord-005453-4057qib7 9922 25 , , , cord-005453-4057qib7 9922 26 p p NN cord-005453-4057qib7 9922 27 < < XX cord-005453-4057qib7 9922 28 0.001 0.001 CD cord-005453-4057qib7 9922 29 ; ; : cord-005453-4057qib7 9922 30 69 69 CD cord-005453-4057qib7 9922 31 % % NN cord-005453-4057qib7 9922 32 vs. vs. IN cord-005453-4057qib7 9922 33 40 40 CD cord-005453-4057qib7 9922 34 % % NN cord-005453-4057qib7 9922 35 , , , cord-005453-4057qib7 9922 36 p p NN cord-005453-4057qib7 9922 37 < < XX cord-005453-4057qib7 9922 38 0.001 0.001 CD cord-005453-4057qib7 9922 39 ; ; : cord-005453-4057qib7 9922 40 66 66 CD cord-005453-4057qib7 9922 41 % % NN cord-005453-4057qib7 9922 42 vs. vs. IN cord-005453-4057qib7 9922 43 45 45 CD cord-005453-4057qib7 9922 44 % % NN cord-005453-4057qib7 9922 45 , , , cord-005453-4057qib7 9922 46 p p NN cord-005453-4057qib7 9922 47 = = SYM cord-005453-4057qib7 9922 48 0.001 0.001 CD cord-005453-4057qib7 9922 49 , , , cord-005453-4057qib7 9922 50 respectively respectively RB cord-005453-4057qib7 9922 51 ) ) -RRB- cord-005453-4057qib7 9922 52 . . . cord-005453-4057qib7 9923 1 High high JJ cord-005453-4057qib7 9923 2 CD3-CD56 cd3-cd56 NN cord-005453-4057qib7 9923 3 + + CC cord-005453-4057qib7 9924 1 cells cell NNS cord-005453-4057qib7 9924 2 were be VBD cord-005453-4057qib7 9924 3 significantly significantly RB cord-005453-4057qib7 9924 4 associated associate VBN cord-005453-4057qib7 9924 5 with with IN cord-005453-4057qib7 9924 6 lower low JJR cord-005453-4057qib7 9924 7 NRM NRM NNP cord-005453-4057qib7 9924 8 ( ( -LRB- cord-005453-4057qib7 9924 9 7 7 CD cord-005453-4057qib7 9924 10 % % NN cord-005453-4057qib7 9924 11 vs. vs. IN cord-005453-4057qib7 9924 12 26 26 CD cord-005453-4057qib7 9924 13 % % NN cord-005453-4057qib7 9924 14 , , , cord-005453-4057qib7 9924 15 p p NN cord-005453-4057qib7 9924 16 = = SYM cord-005453-4057qib7 9924 17 0.002 0.002 CD cord-005453-4057qib7 9924 18 ) ) -RRB- cord-005453-4057qib7 9924 19 , , , cord-005453-4057qib7 9924 20 while while IN cord-005453-4057qib7 9924 21 high high JJ cord-005453-4057qib7 9924 22 CD16+CD57-cells cd16+cd57-cell NNS cord-005453-4057qib7 9924 23 were be VBD cord-005453-4057qib7 9924 24 significantly significantly RB cord-005453-4057qib7 9924 25 associated associate VBN cord-005453-4057qib7 9924 26 with with IN cord-005453-4057qib7 9924 27 lower low JJR cord-005453-4057qib7 9924 28 CIR CIR NNP cord-005453-4057qib7 9924 29 ( ( -LRB- cord-005453-4057qib7 9924 30 26 26 CD cord-005453-4057qib7 9924 31 % % NN cord-005453-4057qib7 9924 32 vs. vs. CC cord-005453-4057qib7 9924 33 50 50 CD cord-005453-4057qib7 9924 34 % % NN cord-005453-4057qib7 9924 35 , , , cord-005453-4057qib7 9924 36 p p NN cord-005453-4057qib7 9924 37 = = SYM cord-005453-4057qib7 9924 38 0.007 0.007 CD cord-005453-4057qib7 9924 39 ) ) -RRB- cord-005453-4057qib7 9924 40 . . . cord-005453-4057qib7 9925 1 Multivariate multivariate JJ cord-005453-4057qib7 9925 2 analysis analysis NN cord-005453-4057qib7 9925 3 confirmed confirm VBD cord-005453-4057qib7 9925 4 these these DT cord-005453-4057qib7 9925 5 NK NK NNP cord-005453-4057qib7 9925 6 cell cell NN cord-005453-4057qib7 9925 7 subsets subset NNS cord-005453-4057qib7 9925 8 as as IN cord-005453-4057qib7 9925 9 prognostic prognostic JJ cord-005453-4057qib7 9925 10 factors factor NNS cord-005453-4057qib7 9925 11 in in IN cord-005453-4057qib7 9925 12 CMVR+ CMVR+ NNP cord-005453-4057qib7 9925 13 patients patient NNS cord-005453-4057qib7 9925 14 . . . cord-005453-4057qib7 9926 1 Conclusions conclusion NNS cord-005453-4057qib7 9926 2 : : : cord-005453-4057qib7 9926 3 NK nk NN cord-005453-4057qib7 9926 4 cell cell NN cord-005453-4057qib7 9926 5 reconstitution reconstitution NN cord-005453-4057qib7 9926 6 may may MD cord-005453-4057qib7 9926 7 contribute contribute VB cord-005453-4057qib7 9926 8 to to IN cord-005453-4057qib7 9926 9 improved improve VBN cord-005453-4057qib7 9926 10 transplantation transplantation NN cord-005453-4057qib7 9926 11 outcomes outcome NNS cord-005453-4057qib7 9926 12 in in IN cord-005453-4057qib7 9926 13 subgroups subgroup NNS cord-005453-4057qib7 9926 14 of of IN cord-005453-4057qib7 9926 15 CMVR CMVR NNP cord-005453-4057qib7 9926 16 + + SYM cord-005453-4057qib7 9926 17 patients patient NNS cord-005453-4057qib7 9926 18 . . . cord-005453-4057qib7 9927 1 Disclosure disclosure NN cord-005453-4057qib7 9927 2 : : : cord-005453-4057qib7 9927 3 Nothing nothing NN cord-005453-4057qib7 9927 4 to to TO cord-005453-4057qib7 9927 5 declare declare VB cord-005453-4057qib7 9927 6 Background background NN cord-005453-4057qib7 9927 7 : : : cord-005453-4057qib7 9927 8 Rezafungin Rezafungin NNP cord-005453-4057qib7 9927 9 ( ( -LRB- cord-005453-4057qib7 9927 10 RZF RZF NNP cord-005453-4057qib7 9927 11 ) ) -RRB- cord-005453-4057qib7 9927 12 is be VBZ cord-005453-4057qib7 9927 13 a a DT cord-005453-4057qib7 9927 14 novel novel JJ cord-005453-4057qib7 9927 15 echinocandin echinocandin NNS cord-005453-4057qib7 9927 16 in in IN cord-005453-4057qib7 9927 17 development development NN cord-005453-4057qib7 9927 18 for for IN cord-005453-4057qib7 9927 19 prevention prevention NN cord-005453-4057qib7 9927 20 of of IN cord-005453-4057qib7 9927 21 invasive invasive JJ cord-005453-4057qib7 9927 22 fungal fungal JJ cord-005453-4057qib7 9927 23 infections infection NNS cord-005453-4057qib7 9927 24 caused cause VBN cord-005453-4057qib7 9927 25 by by IN cord-005453-4057qib7 9927 26 Candida Candida NNP cord-005453-4057qib7 9927 27 , , , cord-005453-4057qib7 9927 28 Aspergillus Aspergillus NNP cord-005453-4057qib7 9927 29 , , , cord-005453-4057qib7 9927 30 and and CC cord-005453-4057qib7 9927 31 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9927 32 spp spp NNS cord-005453-4057qib7 9927 33 . . . cord-005453-4057qib7 9928 1 in in IN cord-005453-4057qib7 9928 2 patients patient NNS cord-005453-4057qib7 9928 3 at at IN cord-005453-4057qib7 9928 4 high high JJ cord-005453-4057qib7 9928 5 risk risk NN cord-005453-4057qib7 9928 6 of of IN cord-005453-4057qib7 9928 7 infection infection NN cord-005453-4057qib7 9928 8 . . . cord-005453-4057qib7 9929 1 RZF RZF NNP cord-005453-4057qib7 9929 2 has have VBZ cord-005453-4057qib7 9929 3 demonstrated demonstrate VBN cord-005453-4057qib7 9929 4 in in IN cord-005453-4057qib7 9929 5 vivo vivo NN cord-005453-4057qib7 9929 6 prophylaxis prophylaxis NN cord-005453-4057qib7 9929 7 efficacy efficacy NN cord-005453-4057qib7 9929 8 and and CC cord-005453-4057qib7 9929 9 low low JJ cord-005453-4057qib7 9929 10 risk risk NN cord-005453-4057qib7 9929 11 of of IN cord-005453-4057qib7 9929 12 drug drug NN cord-005453-4057qib7 9929 13 - - HYPH cord-005453-4057qib7 9929 14 drug drug NN cord-005453-4057qib7 9929 15 interactions interaction NNS cord-005453-4057qib7 9929 16 . . . cord-005453-4057qib7 9930 1 Furthermore furthermore RB cord-005453-4057qib7 9930 2 , , , cord-005453-4057qib7 9930 3 the the DT cord-005453-4057qib7 9930 4 stability stability NN cord-005453-4057qib7 9930 5 and and CC cord-005453-4057qib7 9930 6 PK PK NNP cord-005453-4057qib7 9930 7 profile profile NN cord-005453-4057qib7 9930 8 of of IN cord-005453-4057qib7 9930 9 RZF RZF NNP cord-005453-4057qib7 9930 10 allow allow VB cord-005453-4057qib7 9930 11 for for IN cord-005453-4057qib7 9930 12 once once RB cord-005453-4057qib7 9930 13 - - HYPH cord-005453-4057qib7 9930 14 weekly weekly NN cord-005453-4057qib7 9930 15 dosing dosing NN cord-005453-4057qib7 9930 16 . . . cord-005453-4057qib7 9931 1 RZF RZF NNP cord-005453-4057qib7 9931 2 is be VBZ cord-005453-4057qib7 9931 3 also also RB cord-005453-4057qib7 9931 4 in in IN cord-005453-4057qib7 9931 5 development development NN cord-005453-4057qib7 9931 6 for for IN cord-005453-4057qib7 9931 7 treatment treatment NN cord-005453-4057qib7 9931 8 of of IN cord-005453-4057qib7 9931 9 candidemia candidemia NN cord-005453-4057qib7 9931 10 and and CC cord-005453-4057qib7 9931 11 invasive invasive JJ cord-005453-4057qib7 9931 12 candidiasis candidiasi NNS cord-005453-4057qib7 9931 13 using use VBG cord-005453-4057qib7 9931 14 a a DT cord-005453-4057qib7 9931 15 dosing dose VBG cord-005453-4057qib7 9931 16 regimen regimen NN cord-005453-4057qib7 9931 17 of of IN cord-005453-4057qib7 9931 18 RZF RZF NNP cord-005453-4057qib7 9931 19 400 400 CD cord-005453-4057qib7 9931 20 mg mg NNS cord-005453-4057qib7 9931 21 followed follow VBD cord-005453-4057qib7 9931 22 by by IN cord-005453-4057qib7 9931 23 200 200 CD cord-005453-4057qib7 9931 24 mg mg NNP cord-005453-4057qib7 9931 25 once once RB cord-005453-4057qib7 9931 26 - - HYPH cord-005453-4057qib7 9931 27 weekly weekly NN cord-005453-4057qib7 9931 28 , , , cord-005453-4057qib7 9931 29 which which WDT cord-005453-4057qib7 9931 30 achieved achieve VBD cord-005453-4057qib7 9931 31 > > XX cord-005453-4057qib7 9931 32 90 90 CD cord-005453-4057qib7 9931 33 % % NN cord-005453-4057qib7 9931 34 target target NN cord-005453-4057qib7 9931 35 attainment attainment JJ cord-005453-4057qib7 9931 36 against against IN cord-005453-4057qib7 9931 37 Candida Candida NNP cord-005453-4057qib7 9931 38 . . . cord-005453-4057qib7 9932 1 While while IN cord-005453-4057qib7 9932 2 lower low JJR cord-005453-4057qib7 9932 3 doses dose NNS cord-005453-4057qib7 9932 4 might may MD cord-005453-4057qib7 9932 5 be be VB cord-005453-4057qib7 9932 6 useful useful JJ cord-005453-4057qib7 9932 7 to to TO cord-005453-4057qib7 9932 8 prevent prevent VB cord-005453-4057qib7 9932 9 Candida Candida NNP cord-005453-4057qib7 9932 10 and and CC cord-005453-4057qib7 9932 11 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 9932 12 , , , cord-005453-4057qib7 9932 13 invasive invasive JJ cord-005453-4057qib7 9932 14 aspergillosis aspergillosis NN cord-005453-4057qib7 9932 15 is be VBZ cord-005453-4057qib7 9932 16 a a DT cord-005453-4057qib7 9932 17 different different JJ cord-005453-4057qib7 9932 18 challenge challenge NN cord-005453-4057qib7 9932 19 . . . cord-005453-4057qib7 9933 1 We -PRON- PRP cord-005453-4057qib7 9933 2 evaluated evaluate VBD cord-005453-4057qib7 9933 3 RZF RZF NNP cord-005453-4057qib7 9933 4 dosing dose VBG cord-005453-4057qib7 9933 5 for for IN cord-005453-4057qib7 9933 6 prophylaxis prophylaxis NN cord-005453-4057qib7 9933 7 against against IN cord-005453-4057qib7 9933 8 Aspergillus aspergillus NN cord-005453-4057qib7 9933 9 fumigatus fumigatus NN cord-005453-4057qib7 9933 10 in in IN cord-005453-4057qib7 9933 11 blood blood NN cord-005453-4057qib7 9933 12 and and CC cord-005453-4057qib7 9933 13 marrow marrow NN cord-005453-4057qib7 9933 14 transplant transplant NN cord-005453-4057qib7 9933 15 ( ( -LRB- cord-005453-4057qib7 9933 16 BMT BMT NNP cord-005453-4057qib7 9933 17 ) ) -RRB- cord-005453-4057qib7 9933 18 patients patient NNS cord-005453-4057qib7 9933 19 using use VBG cord-005453-4057qib7 9933 20 PK PK NNP cord-005453-4057qib7 9933 21 / / SYM cord-005453-4057qib7 9933 22 PD PD NNP cord-005453-4057qib7 9933 23 simulations simulation NNS cord-005453-4057qib7 9933 24 of of IN cord-005453-4057qib7 9933 25 the the DT cord-005453-4057qib7 9933 26 treatment treatment NN cord-005453-4057qib7 9933 27 dosing dose VBG cord-005453-4057qib7 9933 28 regimen regimen NN cord-005453-4057qib7 9933 29 . . . cord-005453-4057qib7 9934 1 Methods method NNS cord-005453-4057qib7 9934 2 : : : cord-005453-4057qib7 9935 1 A a DT cord-005453-4057qib7 9935 2 previous previous JJ cord-005453-4057qib7 9935 3 population population NN cord-005453-4057qib7 9935 4 PK PK NNP cord-005453-4057qib7 9935 5 model model NN cord-005453-4057qib7 9935 6 was be VBD cord-005453-4057qib7 9935 7 refined refine VBN cord-005453-4057qib7 9935 8 using use VBG cord-005453-4057qib7 9935 9 data datum NNS cord-005453-4057qib7 9935 10 from from IN cord-005453-4057qib7 9935 11 Phase phase NN cord-005453-4057qib7 9935 12 1 1 CD cord-005453-4057qib7 9935 13 and and CC cord-005453-4057qib7 9935 14 Phase phase NN cord-005453-4057qib7 9935 15 2 2 CD cord-005453-4057qib7 9935 16 trials trial NNS cord-005453-4057qib7 9935 17 of of IN cord-005453-4057qib7 9935 18 IV IV NNP cord-005453-4057qib7 9935 19 RZF RZF NNP cord-005453-4057qib7 9936 1 ( ( -LRB- cord-005453-4057qib7 9936 2 NONMEM NONMEM NNP cord-005453-4057qib7 9936 3 Vers Vers NNP cord-005453-4057qib7 9936 4 7.2 7.2 CD cord-005453-4057qib7 9936 5 ) ) -RRB- cord-005453-4057qib7 9936 6 . . . cord-005453-4057qib7 9937 1 Stepwise Stepwise NNP cord-005453-4057qib7 9937 2 forward forward RB cord-005453-4057qib7 9937 3 selection selection NN cord-005453-4057qib7 9937 4 ( ( -LRB- cord-005453-4057qib7 9937 5 α α NN cord-005453-4057qib7 9937 6 = = SYM cord-005453-4057qib7 9937 7 0.01 0.01 CD cord-005453-4057qib7 9937 8 ) ) -RRB- cord-005453-4057qib7 9937 9 and and CC cord-005453-4057qib7 9937 10 backward backward JJ cord-005453-4057qib7 9937 11 elimination elimination NN cord-005453-4057qib7 9937 12 ( ( -LRB- cord-005453-4057qib7 9937 13 α α NN cord-005453-4057qib7 9937 14 = = SYM cord-005453-4057qib7 9937 15 0.001 0.001 CD cord-005453-4057qib7 9937 16 ) ) -RRB- cord-005453-4057qib7 9937 17 were be VBD cord-005453-4057qib7 9937 18 used use VBN cord-005453-4057qib7 9937 19 to to TO cord-005453-4057qib7 9937 20 assess assess VB cord-005453-4057qib7 9937 21 for for IN cord-005453-4057qib7 9937 22 relationships relationship NNS cord-005453-4057qib7 9937 23 between between IN cord-005453-4057qib7 9937 24 interindividual interindividual NNP cord-005453-4057qib7 9937 25 PK PK NNP cord-005453-4057qib7 9937 26 variability variability NN cord-005453-4057qib7 9937 27 and and CC cord-005453-4057qib7 9937 28 covariates covariate NNS cord-005453-4057qib7 9937 29 , , , cord-005453-4057qib7 9937 30 such such JJ cord-005453-4057qib7 9937 31 as as IN cord-005453-4057qib7 9937 32 age age NN cord-005453-4057qib7 9937 33 , , , cord-005453-4057qib7 9937 34 sex sex NN cord-005453-4057qib7 9937 35 , , , cord-005453-4057qib7 9937 36 BSA BSA NNP cord-005453-4057qib7 9937 37 , , , cord-005453-4057qib7 9937 38 albumin albumin NN cord-005453-4057qib7 9937 39 , , , cord-005453-4057qib7 9937 40 liver liver NN cord-005453-4057qib7 9937 41 and and CC cord-005453-4057qib7 9937 42 renal renal JJ cord-005453-4057qib7 9937 43 function function NN cord-005453-4057qib7 9937 44 markers marker NNS cord-005453-4057qib7 9937 45 , , , cord-005453-4057qib7 9937 46 and and CC cord-005453-4057qib7 9937 47 infection infection NN cord-005453-4057qib7 9937 48 status status NN cord-005453-4057qib7 9937 49 . . . cord-005453-4057qib7 9938 1 The the DT cord-005453-4057qib7 9938 2 final final JJ cord-005453-4057qib7 9938 3 model model NN cord-005453-4057qib7 9938 4 was be VBD cord-005453-4057qib7 9938 5 validated validate VBN cord-005453-4057qib7 9938 6 by by IN cord-005453-4057qib7 9938 7 comparing compare VBG cord-005453-4057qib7 9938 8 model model NN cord-005453-4057qib7 9938 9 - - HYPH cord-005453-4057qib7 9938 10 based base VBN cord-005453-4057qib7 9938 11 predictions prediction NNS cord-005453-4057qib7 9938 12 to to IN cord-005453-4057qib7 9938 13 observed observed JJ cord-005453-4057qib7 9938 14 data datum NNS cord-005453-4057qib7 9938 15 . . . cord-005453-4057qib7 9939 1 The the DT cord-005453-4057qib7 9939 2 model model NN cord-005453-4057qib7 9939 3 and and CC cord-005453-4057qib7 9939 4 demographic demographic JJ cord-005453-4057qib7 9939 5 data datum NNS cord-005453-4057qib7 9939 6 from from IN cord-005453-4057qib7 9939 7 100 100 CD cord-005453-4057qib7 9939 8 BMT BMT NNP cord-005453-4057qib7 9939 9 recipients recipient NNS cord-005453-4057qib7 9939 10 at at IN cord-005453-4057qib7 9939 11 Stanford Stanford NNP cord-005453-4057qib7 9939 12 Medical Medical NNP cord-005453-4057qib7 9939 13 Center Center NNP cord-005453-4057qib7 9939 14 were be VBD cord-005453-4057qib7 9939 15 used use VBN cord-005453-4057qib7 9939 16 for for IN cord-005453-4057qib7 9939 17 Monte Monte NNP cord-005453-4057qib7 9939 18 Carlo Carlo NNP cord-005453-4057qib7 9939 19 simulation simulation NN cord-005453-4057qib7 9939 20 ( ( -LRB- cord-005453-4057qib7 9939 21 n=2,000 n=2,000 NNP cord-005453-4057qib7 9939 22 ) ) -RRB- cord-005453-4057qib7 9939 23 of of IN cord-005453-4057qib7 9939 24 expected expect VBN cord-005453-4057qib7 9939 25 RZF RZF NNP cord-005453-4057qib7 9939 26 concentrationtime concentrationtime NN cord-005453-4057qib7 9939 27 profiles profile NNS cord-005453-4057qib7 9939 28 in in IN cord-005453-4057qib7 9939 29 BMT BMT NNP cord-005453-4057qib7 9939 30 patients patient NNS cord-005453-4057qib7 9939 31 receiving receive VBG cord-005453-4057qib7 9939 32 IV IV NNP cord-005453-4057qib7 9939 33 RZF RZF NNP cord-005453-4057qib7 9939 34 400 400 CD cord-005453-4057qib7 9939 35 mg mg NN cord-005453-4057qib7 9939 36 on on IN cord-005453-4057qib7 9939 37 Week week NN cord-005453-4057qib7 9939 38 1 1 CD cord-005453-4057qib7 9939 39 followed follow VBD cord-005453-4057qib7 9939 40 by by IN cord-005453-4057qib7 9939 41 200 200 CD cord-005453-4057qib7 9939 42 mg mg NNP cord-005453-4057qib7 9939 43 weekly weekly NN cord-005453-4057qib7 9939 44 x x SYM cord-005453-4057qib7 9939 45 11 11 CD cord-005453-4057qib7 9939 46 . . . cord-005453-4057qib7 9940 1 Of of IN cord-005453-4057qib7 9940 2 the the DT cord-005453-4057qib7 9940 3 100 100 CD cord-005453-4057qib7 9940 4 patients patient NNS cord-005453-4057qib7 9940 5 included include VBN cord-005453-4057qib7 9940 6 in in IN cord-005453-4057qib7 9940 7 the the DT cord-005453-4057qib7 9940 8 demographic demographic JJ cord-005453-4057qib7 9940 9 dataset dataset NN cord-005453-4057qib7 9940 10 , , , cord-005453-4057qib7 9940 11 39 39 CD cord-005453-4057qib7 9940 12 were be VBD cord-005453-4057qib7 9940 13 female female JJ cord-005453-4057qib7 9940 14 ( ( -LRB- cord-005453-4057qib7 9940 15 mean mean JJ cord-005453-4057qib7 9940 16 values value NNS cord-005453-4057qib7 9940 17 at at IN cord-005453-4057qib7 9940 18 baseline baseline NN cord-005453-4057qib7 9940 19 : : : cord-005453-4057qib7 9940 20 age age NN cord-005453-4057qib7 9940 21 , , , cord-005453-4057qib7 9940 22 58 58 CD cord-005453-4057qib7 9940 23 years year NNS cord-005453-4057qib7 9940 24 [ [ -LRB- cord-005453-4057qib7 9940 25 19 19 CD cord-005453-4057qib7 9940 26 - - SYM cord-005453-4057qib7 9940 27 75 75 CD cord-005453-4057qib7 9940 28 years year NNS cord-005453-4057qib7 9940 29 ] ] -RRB- cord-005453-4057qib7 9940 30 ; ; : cord-005453-4057qib7 9940 31 weight weight NN cord-005453-4057qib7 9940 32 , , , cord-005453-4057qib7 9940 33 69.8 69.8 CD cord-005453-4057qib7 9940 34 kg kg NN cord-005453-4057qib7 9940 35 [ [ -LRB- cord-005453-4057qib7 9940 36 42 42 CD cord-005453-4057qib7 9940 37 - - SYM cord-005453-4057qib7 9940 38 123 123 CD cord-005453-4057qib7 9940 39 kg kg NNS cord-005453-4057qib7 9940 40 ] ] -RRB- cord-005453-4057qib7 9940 41 ) ) -RRB- cord-005453-4057qib7 9940 42 . . . cord-005453-4057qib7 9941 1 The the DT cord-005453-4057qib7 9941 2 median median NN cord-005453-4057qib7 9941 3 ( ( -LRB- cord-005453-4057qib7 9941 4 range range NN cord-005453-4057qib7 9941 5 ) ) -RRB- cord-005453-4057qib7 9941 6 BSA BSA NNP cord-005453-4057qib7 9941 7 in in IN cord-005453-4057qib7 9941 8 the the DT cord-005453-4057qib7 9941 9 demographic demographic JJ cord-005453-4057qib7 9941 10 dataset dataset NN cord-005453-4057qib7 9941 11 was be VBD cord-005453-4057qib7 9941 12 1.84 1.84 CD cord-005453-4057qib7 9941 13 m m NN cord-005453-4057qib7 9941 14 2 2 CD cord-005453-4057qib7 9941 15 ( ( -LRB- cord-005453-4057qib7 9941 16 1.27 1.27 CD cord-005453-4057qib7 9941 17 - - SYM cord-005453-4057qib7 9941 18 2.61 2.61 CD cord-005453-4057qib7 9941 19 ) ) -RRB- cord-005453-4057qib7 9941 20 , , , cord-005453-4057qib7 9941 21 and and CC cord-005453-4057qib7 9941 22 albumin albumin NN cord-005453-4057qib7 9941 23 was be VBD cord-005453-4057qib7 9941 24 3.35 3.35 CD cord-005453-4057qib7 9941 25 g g NN cord-005453-4057qib7 9941 26 / / SYM cord-005453-4057qib7 9941 27 dL dl NN cord-005453-4057qib7 9941 28 ( ( -LRB- cord-005453-4057qib7 9941 29 1.8 1.8 CD cord-005453-4057qib7 9941 30 - - SYM cord-005453-4057qib7 9941 31 4.43 4.43 CD cord-005453-4057qib7 9941 32 g g NN cord-005453-4057qib7 9941 33 / / SYM cord-005453-4057qib7 9941 34 dL dl NN cord-005453-4057qib7 9941 35 ) ) -RRB- cord-005453-4057qib7 9941 36 . . . cord-005453-4057qib7 9942 1 Free free JJ cord-005453-4057qib7 9942 2 - - HYPH cord-005453-4057qib7 9942 3 drug drug NN cord-005453-4057qib7 9942 4 concentration concentration NN cord-005453-4057qib7 9942 5 - - HYPH cord-005453-4057qib7 9942 6 time time NN cord-005453-4057qib7 9942 7 profiles profile NNS cord-005453-4057qib7 9942 8 were be VBD cord-005453-4057qib7 9942 9 evaluated evaluate VBN cord-005453-4057qib7 9942 10 ( ( -LRB- cord-005453-4057qib7 9942 11 97.4 97.4 CD cord-005453-4057qib7 9942 12 % % NN cord-005453-4057qib7 9942 13 human human JJ cord-005453-4057qib7 9942 14 protein protein NN cord-005453-4057qib7 9942 15 - - HYPH cord-005453-4057qib7 9942 16 binding bind VBG cord-005453-4057qib7 9942 17 ) ) -RRB- cord-005453-4057qib7 9942 18 relative relative NN cord-005453-4057qib7 9942 19 to to IN cord-005453-4057qib7 9942 20 the the DT cord-005453-4057qib7 9942 21 A. a. NN cord-005453-4057qib7 9942 22 fumigatus fumigatus NN cord-005453-4057qib7 9942 23 minimal minimal JJ cord-005453-4057qib7 9942 24 effective effective JJ cord-005453-4057qib7 9942 25 concentration concentration NN cord-005453-4057qib7 9942 26 required require VBN cord-005453-4057qib7 9942 27 to to TO cord-005453-4057qib7 9942 28 inhibit inhibit VB cord-005453-4057qib7 9942 29 100 100 CD cord-005453-4057qib7 9942 30 % % NN cord-005453-4057qib7 9942 31 of of IN cord-005453-4057qib7 9942 32 isolates isolate NNS cord-005453-4057qib7 9942 33 tested test VBN cord-005453-4057qib7 9942 34 ( ( -LRB- cord-005453-4057qib7 9942 35 MEC MEC NNP cord-005453-4057qib7 9942 36 100 100 CD cord-005453-4057qib7 9942 37 ; ; : cord-005453-4057qib7 9942 38 JMI JMI NNP cord-005453-4057qib7 9942 39 2014 2014 CD cord-005453-4057qib7 9942 40 - - SYM cord-005453-4057qib7 9942 41 2017 2017 CD cord-005453-4057qib7 9942 42 SENTRY SENTRY NNP cord-005453-4057qib7 9942 43 international international JJ cord-005453-4057qib7 9942 44 surveillance surveillance NN cord-005453-4057qib7 9942 45 data datum NNS cord-005453-4057qib7 9942 46 ) ) -RRB- cord-005453-4057qib7 9942 47 . . . cord-005453-4057qib7 9943 1 Results result NNS cord-005453-4057qib7 9943 2 : : : cord-005453-4057qib7 9944 1 The the DT cord-005453-4057qib7 9944 2 population population NN cord-005453-4057qib7 9944 3 PK PK NNP cord-005453-4057qib7 9944 4 model model NN cord-005453-4057qib7 9944 5 was be VBD cord-005453-4057qib7 9944 6 a a DT cord-005453-4057qib7 9944 7 linear linear JJ cord-005453-4057qib7 9944 8 , , , cord-005453-4057qib7 9944 9 4compartment 4compartment CD cord-005453-4057qib7 9944 10 model model NN cord-005453-4057qib7 9944 11 with with IN cord-005453-4057qib7 9944 12 zero zero CD cord-005453-4057qib7 9944 13 order order NN cord-005453-4057qib7 9944 14 IV IV NNP cord-005453-4057qib7 9944 15 input input NN cord-005453-4057qib7 9944 16 . . . cord-005453-4057qib7 9945 1 Albumin albumin NN cord-005453-4057qib7 9945 2 , , , cord-005453-4057qib7 9945 3 sex sex NN cord-005453-4057qib7 9945 4 , , , cord-005453-4057qib7 9945 5 infection infection NN cord-005453-4057qib7 9945 6 status status NN cord-005453-4057qib7 9945 7 , , , cord-005453-4057qib7 9945 8 and and CC cord-005453-4057qib7 9945 9 body body NN cord-005453-4057qib7 9945 10 surface surface NN cord-005453-4057qib7 9945 11 area area NN cord-005453-4057qib7 9945 12 were be VBD cord-005453-4057qib7 9945 13 statistically statistically RB cord-005453-4057qib7 9945 14 significant significant JJ cord-005453-4057qib7 9945 15 predictors predictor NNS cord-005453-4057qib7 9945 16 of of IN cord-005453-4057qib7 9945 17 interindividual interindividual JJ cord-005453-4057qib7 9945 18 variability variability NN cord-005453-4057qib7 9945 19 ; ; : cord-005453-4057qib7 9945 20 clinical clinical JJ cord-005453-4057qib7 9945 21 significance significance NN cord-005453-4057qib7 9945 22 of of IN cord-005453-4057qib7 9945 23 these these DT cord-005453-4057qib7 9945 24 factors factor NNS cord-005453-4057qib7 9945 25 was be VBD cord-005453-4057qib7 9945 26 not not RB cord-005453-4057qib7 9945 27 determined determine VBN cord-005453-4057qib7 9945 28 . . . cord-005453-4057qib7 9946 1 The the DT cord-005453-4057qib7 9946 2 model model NN cord-005453-4057qib7 9946 3 provided provide VBD cord-005453-4057qib7 9946 4 precise precise JJ cord-005453-4057qib7 9946 5 , , , cord-005453-4057qib7 9946 6 unbiased unbiased JJ cord-005453-4057qib7 9946 7 fits fit NNS cord-005453-4057qib7 9946 8 to to IN cord-005453-4057qib7 9946 9 the the DT cord-005453-4057qib7 9946 10 observed observed JJ cord-005453-4057qib7 9946 11 data datum NNS cord-005453-4057qib7 9946 12 ( ( -LRB- cord-005453-4057qib7 9946 13 r r NN cord-005453-4057qib7 9946 14 2 2 CD cord-005453-4057qib7 9946 15 = = SYM cord-005453-4057qib7 9946 16 0.993 0.993 CD cord-005453-4057qib7 9946 17 observed observe VBD cord-005453-4057qib7 9946 18 vs vs IN cord-005453-4057qib7 9946 19 individual individual NN cord-005453-4057qib7 9946 20 - - HYPH cord-005453-4057qib7 9946 21 predicted predict VBN cord-005453-4057qib7 9946 22 concentrations concentration NNS cord-005453-4057qib7 9946 23 ) ) -RRB- cord-005453-4057qib7 9946 24 . . . cord-005453-4057qib7 9947 1 RZF RZF NNP cord-005453-4057qib7 9947 2 plasma plasma NN cord-005453-4057qib7 9947 3 free free JJ cord-005453-4057qib7 9947 4 - - HYPH cord-005453-4057qib7 9947 5 drug drug NN cord-005453-4057qib7 9947 6 concentrations concentration NNS cord-005453-4057qib7 9947 7 at at IN cord-005453-4057qib7 9947 8 weeks week NNS cord-005453-4057qib7 9947 9 1 1 CD cord-005453-4057qib7 9947 10 , , , cord-005453-4057qib7 9947 11 2 2 CD cord-005453-4057qib7 9947 12 , , , cord-005453-4057qib7 9947 13 and and CC cord-005453-4057qib7 9947 14 12 12 CD cord-005453-4057qib7 9947 15 were be VBD cord-005453-4057qib7 9947 16 above above IN cord-005453-4057qib7 9947 17 the the DT cord-005453-4057qib7 9947 18 A. a. NN cord-005453-4057qib7 9947 19 fumigatus fumigatus NN cord-005453-4057qib7 9947 20 MEC MEC NNP cord-005453-4057qib7 9947 21 100 100 CD cord-005453-4057qib7 9947 22 ( ( -LRB- cord-005453-4057qib7 9947 23 0.03 0.03 CD cord-005453-4057qib7 9947 24 mg mg NNP cord-005453-4057qib7 9947 25 / / SYM cord-005453-4057qib7 9947 26 L L NNP cord-005453-4057qib7 9947 27 ) ) -RRB- cord-005453-4057qib7 9947 28 for for IN cord-005453-4057qib7 9947 29 the the DT cord-005453-4057qib7 9947 30 entire entire JJ cord-005453-4057qib7 9947 31 dosing dosing NN cord-005453-4057qib7 9947 32 interval interval NN cord-005453-4057qib7 9947 33 in in IN cord-005453-4057qib7 9947 34 98.0 98.0 CD cord-005453-4057qib7 9947 35 % % NN cord-005453-4057qib7 9947 36 , , , cord-005453-4057qib7 9947 37 92.0 92.0 CD cord-005453-4057qib7 9947 38 % % NN cord-005453-4057qib7 9947 39 , , , cord-005453-4057qib7 9947 40 and and CC cord-005453-4057qib7 9947 41 90.2 90.2 CD cord-005453-4057qib7 9947 42 % % NN cord-005453-4057qib7 9947 43 of of IN cord-005453-4057qib7 9947 44 simulated simulated JJ cord-005453-4057qib7 9947 45 patients patient NNS cord-005453-4057qib7 9947 46 , , , cord-005453-4057qib7 9947 47 respectively respectively RB cord-005453-4057qib7 9947 48 , , , cord-005453-4057qib7 9947 49 and and CC cord-005453-4057qib7 9947 50 in in IN cord-005453-4057qib7 9947 51 ≥99.8 ≥99.8 JJ cord-005453-4057qib7 9947 52 % % NN cord-005453-4057qib7 9947 53 for for IN cord-005453-4057qib7 9947 54 all all DT cord-005453-4057qib7 9947 55 12 12 CD cord-005453-4057qib7 9947 56 weeks week NNS cord-005453-4057qib7 9947 57 based base VBN cord-005453-4057qib7 9947 58 on on IN cord-005453-4057qib7 9947 59 the the DT cord-005453-4057qib7 9947 60 MEC MEC NNP cord-005453-4057qib7 9947 61 90 90 CD cord-005453-4057qib7 9947 62 ( ( -LRB- cord-005453-4057qib7 9947 63 0.015 0.015 CD cord-005453-4057qib7 9947 64 mg mg NNP cord-005453-4057qib7 9947 65 / / SYM cord-005453-4057qib7 9947 66 L L NNP cord-005453-4057qib7 9947 67 ) ) -RRB- cord-005453-4057qib7 9947 68 . . . cord-005453-4057qib7 9948 1 Conclusions conclusion NNS cord-005453-4057qib7 9948 2 : : : cord-005453-4057qib7 9949 1 These these DT cord-005453-4057qib7 9949 2 data datum NNS cord-005453-4057qib7 9949 3 modelled model VBN cord-005453-4057qib7 9949 4 from from IN cord-005453-4057qib7 9949 5 BMT BMT NNP cord-005453-4057qib7 9949 6 patients patient NNS cord-005453-4057qib7 9949 7 support support VBP cord-005453-4057qib7 9949 8 the the DT cord-005453-4057qib7 9949 9 RZF RZF NNP cord-005453-4057qib7 9949 10 dosing dose VBG cord-005453-4057qib7 9949 11 regimen regimen NN cord-005453-4057qib7 9949 12 of of IN cord-005453-4057qib7 9949 13 400 400 CD cord-005453-4057qib7 9949 14 mg mg NNP cord-005453-4057qib7 9949 15 IV IV NNP cord-005453-4057qib7 9949 16 followed follow VBD cord-005453-4057qib7 9949 17 by by IN cord-005453-4057qib7 9949 18 200 200 CD cord-005453-4057qib7 9949 19 mg mg NNP cord-005453-4057qib7 9949 20 once once RB cord-005453-4057qib7 9949 21 - - HYPH cord-005453-4057qib7 9949 22 weekly weekly NN cord-005453-4057qib7 9949 23 for for IN cord-005453-4057qib7 9949 24 prophylaxis prophylaxis NN cord-005453-4057qib7 9949 25 against against IN cord-005453-4057qib7 9949 26 A. a. NN cord-005453-4057qib7 9949 27 fumigatus fumigatus NN cord-005453-4057qib7 9949 28 . . . cord-005453-4057qib7 9950 1 Current current JJ cord-005453-4057qib7 9950 2 antifungal antifungal JJ cord-005453-4057qib7 9950 3 prophylaxis prophylaxis NN cord-005453-4057qib7 9950 4 may may MD cord-005453-4057qib7 9950 5 be be VB cord-005453-4057qib7 9950 6 limited limit VBN cord-005453-4057qib7 9950 7 by by IN cord-005453-4057qib7 9950 8 toxicity toxicity NN cord-005453-4057qib7 9950 9 , , , cord-005453-4057qib7 9950 10 DDIs ddi NNS cord-005453-4057qib7 9950 11 , , , cord-005453-4057qib7 9950 12 or or CC cord-005453-4057qib7 9950 13 patient patient NN cord-005453-4057qib7 9950 14 factors factor NNS cord-005453-4057qib7 9950 15 such such JJ cord-005453-4057qib7 9950 16 as as IN cord-005453-4057qib7 9950 17 mucositis mucositis NNP cord-005453-4057qib7 9950 18 . . . cord-005453-4057qib7 9951 1 The the DT cord-005453-4057qib7 9951 2 PK PK NNP cord-005453-4057qib7 9951 3 of of IN cord-005453-4057qib7 9951 4 RZF RZF NNP cord-005453-4057qib7 9951 5 and and CC cord-005453-4057qib7 9951 6 its -PRON- PRP$ cord-005453-4057qib7 9951 7 spectrum spectrum NN cord-005453-4057qib7 9951 8 , , , cord-005453-4057qib7 9951 9 safety safety NN cord-005453-4057qib7 9951 10 , , , cord-005453-4057qib7 9951 11 tolerability tolerability NN cord-005453-4057qib7 9951 12 , , , cord-005453-4057qib7 9951 13 and and CC cord-005453-4057qib7 9951 14 lack lack NN cord-005453-4057qib7 9951 15 of of IN cord-005453-4057qib7 9951 16 DDIs ddi NNS cord-005453-4057qib7 9951 17 may may MD cord-005453-4057qib7 9951 18 address address VB cord-005453-4057qib7 9951 19 current current JJ cord-005453-4057qib7 9951 20 unmet unmet JJ cord-005453-4057qib7 9951 21 needs need NNS cord-005453-4057qib7 9951 22 in in IN cord-005453-4057qib7 9951 23 IFI IFI NNP cord-005453-4057qib7 9951 24 prophylaxis prophylaxis NN cord-005453-4057qib7 9951 25 for for IN cord-005453-4057qib7 9951 26 BMT BMT NNP cord-005453-4057qib7 9951 27 and and CC cord-005453-4057qib7 9951 28 other other JJ cord-005453-4057qib7 9951 29 immunocompromised immunocompromised JJ cord-005453-4057qib7 9951 30 patients patient NNS cord-005453-4057qib7 9951 31 . . . cord-005453-4057qib7 9952 1 Disclosure disclosure NN cord-005453-4057qib7 9952 2 : : : cord-005453-4057qib7 9952 3 Janice Janice NNP cord-005453-4057qib7 9952 4 Brown Brown NNP cord-005453-4057qib7 9952 5 : : : cord-005453-4057qib7 9952 6 Research research NN cord-005453-4057qib7 9952 7 funding funding NN cord-005453-4057qib7 9952 8 , , , cord-005453-4057qib7 9952 9 Cidara Cidara NNP cord-005453-4057qib7 9952 10 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9952 11 , , , cord-005453-4057qib7 9952 12 Elizabeth Elizabeth NNP cord-005453-4057qib7 9952 13 Lakota Lakota NNP cord-005453-4057qib7 9952 14 : : : cord-005453-4057qib7 9952 15 Research research NN cord-005453-4057qib7 9952 16 funding funding NN cord-005453-4057qib7 9952 17 , , , cord-005453-4057qib7 9952 18 Cidara Cidara NNP cord-005453-4057qib7 9952 19 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9952 20 , , , cord-005453-4057qib7 9952 21 Shawn Shawn NNP cord-005453-4057qib7 9952 22 Flanagan Flanagan NNP cord-005453-4057qib7 9953 1 : : : cord-005453-4057qib7 9953 2 Employment employment NN cord-005453-4057qib7 9953 3 , , , cord-005453-4057qib7 9953 4 Cidara Cidara NNP cord-005453-4057qib7 9953 5 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9953 6 , , , cord-005453-4057qib7 9953 7 Taylor Taylor NNP cord-005453-4057qib7 9953 8 Sandison Sandison NNP cord-005453-4057qib7 9953 9 : : : cord-005453-4057qib7 9953 10 Employment Employment NNP cord-005453-4057qib7 9953 11 , , , cord-005453-4057qib7 9953 12 Cidara Cidara NNP cord-005453-4057qib7 9953 13 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9953 14 , , , cord-005453-4057qib7 9953 15 Voon Voon NNP cord-005453-4057qib7 9953 16 Ong Ong NNP cord-005453-4057qib7 9953 17 : : : cord-005453-4057qib7 9953 18 Employment Employment NNP cord-005453-4057qib7 9953 19 , , , cord-005453-4057qib7 9953 20 Cidara Cidara NNP cord-005453-4057qib7 9953 21 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9953 22 , , , cord-005453-4057qib7 9953 23 Christopher Christopher NNP cord-005453-4057qib7 9953 24 Rubino Rubino NNP cord-005453-4057qib7 9953 25 : : : cord-005453-4057qib7 9953 26 Research research NN cord-005453-4057qib7 9953 27 funding funding NN cord-005453-4057qib7 9953 28 , , , cord-005453-4057qib7 9953 29 Cidara Cidara NNP cord-005453-4057qib7 9953 30 Therapeutics Therapeutics NNPS cord-005453-4057qib7 9953 31 P444 P444 NNP cord-005453-4057qib7 9954 1 Is be VBZ cord-005453-4057qib7 9954 2 fungal fungal JJ cord-005453-4057qib7 9954 3 prophylaxis prophylaxis NN cord-005453-4057qib7 9954 4 necessary necessary JJ cord-005453-4057qib7 9954 5 in in IN cord-005453-4057qib7 9954 6 non non JJ cord-005453-4057qib7 9954 7 myeloablative myeloablative JJ cord-005453-4057qib7 9954 8 peripheral peripheral JJ cord-005453-4057qib7 9954 9 blood blood NN cord-005453-4057qib7 9954 10 stem stem NN cord-005453-4057qib7 9954 11 cell cell NN cord-005453-4057qib7 9954 12 allogeneic allogeneic NN cord-005453-4057qib7 9954 13 transplantation transplantation NN cord-005453-4057qib7 9954 14 in in IN cord-005453-4057qib7 9954 15 the the DT cord-005453-4057qib7 9954 16 pre pre JJ cord-005453-4057qib7 9954 17 - - JJ cord-005453-4057qib7 9954 18 engrafment engrafment JJ cord-005453-4057qib7 9954 19 period period NN cord-005453-4057qib7 9954 20 ? ? . cord-005453-4057qib7 9955 1 Julien Julien NNP cord-005453-4057qib7 9955 2 Vaidie Vaidie NNP cord-005453-4057qib7 9955 3 1 1 CD cord-005453-4057qib7 9955 4 , , , cord-005453-4057qib7 9955 5 Jean Jean NNP cord-005453-4057qib7 9955 6 - - HYPH cord-005453-4057qib7 9955 7 Baptiste Baptiste NNP cord-005453-4057qib7 9955 8 Woillard Woillard NNP cord-005453-4057qib7 9955 9 1 1 CD cord-005453-4057qib7 9955 10 , , , cord-005453-4057qib7 9955 11 Stéphane Stéphane NNP cord-005453-4057qib7 9955 12 Girault Girault NNP cord-005453-4057qib7 9955 13 1 1 CD cord-005453-4057qib7 9955 14 , , , cord-005453-4057qib7 9955 15 Marie Marie NNP cord-005453-4057qib7 9955 16 - - HYPH cord-005453-4057qib7 9955 17 Laure Laure NNP cord-005453-4057qib7 9955 18 Dardé Dardé NNP cord-005453-4057qib7 9955 19 1 1 CD cord-005453-4057qib7 9955 20 , , , cord-005453-4057qib7 9955 21 Arnaud Arnaud NNP cord-005453-4057qib7 9955 22 Jaccard Jaccard NNP cord-005453-4057qib7 9955 23 1 1 CD cord-005453-4057qib7 9955 24 , , , cord-005453-4057qib7 9955 25 Daniel Daniel NNP cord-005453-4057qib7 9955 26 Ajzenberg Ajzenberg NNP cord-005453-4057qib7 9955 27 1 1 CD cord-005453-4057qib7 9955 28 , , , cord-005453-4057qib7 9955 29 Bernard Bernard NNP cord-005453-4057qib7 9955 30 Bouteille Bouteille NNP cord-005453-4057qib7 9955 31 1 1 CD cord-005453-4057qib7 9956 1 , , , cord-005453-4057qib7 9956 2 Pascal Pascal NNP cord-005453-4057qib7 9956 3 Turlure Turlure NNP cord-005453-4057qib7 9956 4 1 1 CD cord-005453-4057qib7 9956 5 Background Background NNP cord-005453-4057qib7 9956 6 : : : cord-005453-4057qib7 9956 7 Non non JJ cord-005453-4057qib7 9956 8 myeloablative myeloablative JJ cord-005453-4057qib7 9956 9 peripheral peripheral JJ cord-005453-4057qib7 9956 10 blood blood NN cord-005453-4057qib7 9956 11 stem stem NN cord-005453-4057qib7 9956 12 cell cell NN cord-005453-4057qib7 9956 13 transplantation transplantation NN cord-005453-4057qib7 9956 14 ( ( -LRB- cord-005453-4057qib7 9956 15 PBSC PBSC NNP cord-005453-4057qib7 9956 16 ) ) -RRB- cord-005453-4057qib7 9956 17 , , , cord-005453-4057qib7 9956 18 by by IN cord-005453-4057qib7 9956 19 limiting limit VBG cord-005453-4057qib7 9956 20 toxicity toxicity NN cord-005453-4057qib7 9956 21 , , , cord-005453-4057qib7 9956 22 can can MD cord-005453-4057qib7 9956 23 be be VB cord-005453-4057qib7 9956 24 proposed propose VBN cord-005453-4057qib7 9956 25 to to IN cord-005453-4057qib7 9956 26 elderly elderly JJ cord-005453-4057qib7 9956 27 patients patient NNS cord-005453-4057qib7 9956 28 or or CC cord-005453-4057qib7 9956 29 patients patient NNS cord-005453-4057qib7 9956 30 with with IN cord-005453-4057qib7 9956 31 comorbidities comorbiditie NNS cord-005453-4057qib7 9956 32 . . . cord-005453-4057qib7 9957 1 However however RB cord-005453-4057qib7 9957 2 , , , cord-005453-4057qib7 9957 3 fungal fungal JJ cord-005453-4057qib7 9957 4 infections infection NNS cord-005453-4057qib7 9957 5 remain remain VBP cord-005453-4057qib7 9957 6 a a DT cord-005453-4057qib7 9957 7 key key JJ cord-005453-4057qib7 9957 8 issue issue NN cord-005453-4057qib7 9957 9 that that WDT cord-005453-4057qib7 9957 10 can can MD cord-005453-4057qib7 9957 11 negatively negatively RB cord-005453-4057qib7 9957 12 impact impact VB cord-005453-4057qib7 9957 13 outcome outcome NN cord-005453-4057qib7 9957 14 , , , cord-005453-4057qib7 9957 15 and and CC cord-005453-4057qib7 9957 16 increase increase VB cord-005453-4057qib7 9957 17 duration duration NN cord-005453-4057qib7 9957 18 and and CC cord-005453-4057qib7 9957 19 cost cost NN cord-005453-4057qib7 9957 20 of of IN cord-005453-4057qib7 9957 21 hospitalization hospitalization NN cord-005453-4057qib7 9957 22 . . . cord-005453-4057qib7 9958 1 Systematic systematic JJ cord-005453-4057qib7 9958 2 fungal fungal JJ cord-005453-4057qib7 9958 3 prophylaxis prophylaxis NN cord-005453-4057qib7 9958 4 have have VBP cord-005453-4057qib7 9958 5 demonstrated demonstrate VBN cord-005453-4057qib7 9958 6 benefits benefit NNS cord-005453-4057qib7 9958 7 in in IN cord-005453-4057qib7 9958 8 outcome outcome NN cord-005453-4057qib7 9958 9 in in IN cord-005453-4057qib7 9958 10 the the DT cord-005453-4057qib7 9958 11 context context NN cord-005453-4057qib7 9958 12 of of IN cord-005453-4057qib7 9958 13 myeloablative myeloablative JJ cord-005453-4057qib7 9958 14 conditioning conditioning NN cord-005453-4057qib7 9958 15 but but CC cord-005453-4057qib7 9958 16 are be VBP cord-005453-4057qib7 9958 17 not not RB cord-005453-4057qib7 9958 18 currently currently RB cord-005453-4057qib7 9958 19 in in IN cord-005453-4057qib7 9958 20 reduced reduce VBN cord-005453-4057qib7 9958 21 intensity intensity NN cord-005453-4057qib7 9958 22 conditioning conditioning NN cord-005453-4057qib7 9958 23 allograft allograft NN cord-005453-4057qib7 9958 24 with with IN cord-005453-4057qib7 9958 25 PBSC PBSC NNP cord-005453-4057qib7 9958 26 . . . cord-005453-4057qib7 9959 1 Fluconazole fluconazole NN cord-005453-4057qib7 9959 2 prophylaxis prophylaxis NN cord-005453-4057qib7 9959 3 is be VBZ cord-005453-4057qib7 9959 4 currently currently RB cord-005453-4057qib7 9959 5 recommended recommend VBN cord-005453-4057qib7 9959 6 in in IN cord-005453-4057qib7 9959 7 this this DT cord-005453-4057qib7 9959 8 situation situation NN cord-005453-4057qib7 9959 9 ( ( -LRB- cord-005453-4057qib7 9959 10 ECIL ECIL NNP cord-005453-4057qib7 9959 11 ) ) -RRB- cord-005453-4057qib7 9959 12 . . . cord-005453-4057qib7 9960 1 Methods method NNS cord-005453-4057qib7 9960 2 : : : cord-005453-4057qib7 9960 3 Primary primary JJ cord-005453-4057qib7 9960 4 objective objective NN cord-005453-4057qib7 9960 5 of of IN cord-005453-4057qib7 9960 6 this this DT cord-005453-4057qib7 9960 7 retrospective retrospective JJ cord-005453-4057qib7 9960 8 study study NN cord-005453-4057qib7 9960 9 was be VBD cord-005453-4057qib7 9960 10 to to TO cord-005453-4057qib7 9960 11 evaluate evaluate VB cord-005453-4057qib7 9960 12 fungal fungal JJ cord-005453-4057qib7 9960 13 infection infection NN cord-005453-4057qib7 9960 14 incidence incidence NN cord-005453-4057qib7 9960 15 after after IN cord-005453-4057qib7 9960 16 allograft allograft NN cord-005453-4057qib7 9960 17 procedure procedure NN cord-005453-4057qib7 9960 18 in in IN cord-005453-4057qib7 9960 19 patients patient NNS cord-005453-4057qib7 9960 20 who who WP cord-005453-4057qib7 9960 21 received receive VBD cord-005453-4057qib7 9960 22 a a DT cord-005453-4057qib7 9960 23 non non JJ cord-005453-4057qib7 9960 24 myeloablative myeloablative JJ cord-005453-4057qib7 9960 25 allograft allograft NN cord-005453-4057qib7 9960 26 with with IN cord-005453-4057qib7 9960 27 PBSC PBSC NNP cord-005453-4057qib7 9960 28 in in IN cord-005453-4057qib7 9960 29 Limoges Limoges NNP cord-005453-4057qib7 9960 30 University University NNP cord-005453-4057qib7 9960 31 Hospital Hospital NNP cord-005453-4057qib7 9960 32 between between IN cord-005453-4057qib7 9960 33 june june NNP cord-005453-4057qib7 9960 34 2009 2009 CD cord-005453-4057qib7 9960 35 and and CC cord-005453-4057qib7 9960 36 june june NNP cord-005453-4057qib7 9960 37 2018 2018 CD cord-005453-4057qib7 9960 38 . . . cord-005453-4057qib7 9961 1 Patients patient NNS cord-005453-4057qib7 9961 2 received receive VBD cord-005453-4057qib7 9961 3 Fludarabine Fludarabine NNP cord-005453-4057qib7 9961 4 30 30 CD cord-005453-4057qib7 9961 5 mg mg NNP cord-005453-4057qib7 9961 6 / / SYM cord-005453-4057qib7 9961 7 m2 m2 NNP cord-005453-4057qib7 9961 8 / / SYM cord-005453-4057qib7 9961 9 day day NN cord-005453-4057qib7 9961 10 between between IN cord-005453-4057qib7 9961 11 D-6 D-6 NNP cord-005453-4057qib7 9961 12 and and CC cord-005453-4057qib7 9961 13 D-2 D-2 NNP cord-005453-4057qib7 9961 14 before before IN cord-005453-4057qib7 9961 15 allograft allograft NN cord-005453-4057qib7 9961 16 and and CC cord-005453-4057qib7 9961 17 Busulfan Busulfan NNP cord-005453-4057qib7 9961 18 3.2 3.2 CD cord-005453-4057qib7 9961 19 mg mg NNP cord-005453-4057qib7 9961 20 / / SYM cord-005453-4057qib7 9961 21 kg kg NNP cord-005453-4057qib7 9961 22 / / SYM cord-005453-4057qib7 9961 23 day day NN cord-005453-4057qib7 9961 24 at at IN cord-005453-4057qib7 9961 25 D-4 D-4 NNP cord-005453-4057qib7 9961 26 and and CC cord-005453-4057qib7 9961 27 D-3 D-3 NNP cord-005453-4057qib7 9961 28 . . . cord-005453-4057qib7 9962 1 GvH GvH NNP cord-005453-4057qib7 9962 2 prophylaxis prophylaxis NNP cord-005453-4057qib7 9962 3 consisted consist VBD cord-005453-4057qib7 9962 4 in in IN cord-005453-4057qib7 9962 5 rabbit rabbit NN cord-005453-4057qib7 9962 6 anti anti JJ cord-005453-4057qib7 9962 7 - - JJ cord-005453-4057qib7 9962 8 lymphocyte lymphocyte JJ cord-005453-4057qib7 9962 9 serum serum NN cord-005453-4057qib7 9962 10 at at IN cord-005453-4057qib7 9962 11 the the DT cord-005453-4057qib7 9962 12 dose dose NN cord-005453-4057qib7 9962 13 of of IN cord-005453-4057qib7 9962 14 2.5 2.5 CD cord-005453-4057qib7 9962 15 mg mg NNP cord-005453-4057qib7 9962 16 / / SYM cord-005453-4057qib7 9962 17 kg kg NNS cord-005453-4057qib7 9962 18 at at IN cord-005453-4057qib7 9962 19 D-2 D-2 NNP cord-005453-4057qib7 9962 20 and and CC cord-005453-4057qib7 9962 21 D-1 D-1 NNP cord-005453-4057qib7 9962 22 , , , cord-005453-4057qib7 9962 23 and and CC cord-005453-4057qib7 9962 24 ciclosporin ciclosporin NN cord-005453-4057qib7 9962 25 at at IN cord-005453-4057qib7 9962 26 the the DT cord-005453-4057qib7 9962 27 beginning beginning NN cord-005453-4057qib7 9962 28 dose dose NN cord-005453-4057qib7 9962 29 of of IN cord-005453-4057qib7 9962 30 3mg 3mg NN cord-005453-4057qib7 9962 31 / / SYM cord-005453-4057qib7 9962 32 kg kg NN cord-005453-4057qib7 9962 33 per per IN cord-005453-4057qib7 9962 34 os os NN cord-005453-4057qib7 9962 35 twice twice PDT cord-005453-4057qib7 9962 36 a a DT cord-005453-4057qib7 9962 37 day day NN cord-005453-4057qib7 9962 38 . . . cord-005453-4057qib7 9963 1 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 9963 2 mofetil mofetil NNP cord-005453-4057qib7 9963 3 was be VBD cord-005453-4057qib7 9963 4 adding add VBG cord-005453-4057qib7 9963 5 for for IN cord-005453-4057qib7 9963 6 patients patient NNS cord-005453-4057qib7 9963 7 with with IN cord-005453-4057qib7 9963 8 HLA HLA NNP cord-005453-4057qib7 9963 9 - - HYPH cord-005453-4057qib7 9963 10 matched match VBN cord-005453-4057qib7 9963 11 or or CC cord-005453-4057qib7 9963 12 mismatched mismatch VBN cord-005453-4057qib7 9963 13 unrelated unrelated JJ cord-005453-4057qib7 9963 14 donors donor NNS cord-005453-4057qib7 9963 15 . . . cord-005453-4057qib7 9964 1 Patients patient NNS cord-005453-4057qib7 9964 2 did do VBD cord-005453-4057qib7 9964 3 not not RB cord-005453-4057qib7 9964 4 systematically systematically RB cord-005453-4057qib7 9964 5 receive receive VB cord-005453-4057qib7 9964 6 antifungal antifungal JJ cord-005453-4057qib7 9964 7 prophylaxis prophylaxis NN cord-005453-4057qib7 9964 8 during during IN cord-005453-4057qib7 9964 9 the the DT cord-005453-4057qib7 9964 10 neutropenic neutropenic JJ cord-005453-4057qib7 9964 11 pre pre JJ cord-005453-4057qib7 9964 12 - - JJ cord-005453-4057qib7 9964 13 engraftment engraftment JJ cord-005453-4057qib7 9964 14 period period NN cord-005453-4057qib7 9964 15 . . . cord-005453-4057qib7 9965 1 When when WRB cord-005453-4057qib7 9965 2 patients patient NNS cord-005453-4057qib7 9965 3 had have VBD cord-005453-4057qib7 9965 4 fever fever NN cord-005453-4057qib7 9965 5 during during IN cord-005453-4057qib7 9965 6 more more JJR cord-005453-4057qib7 9965 7 than than IN cord-005453-4057qib7 9965 8 72 72 CD cord-005453-4057qib7 9965 9 hours hour NNS cord-005453-4057qib7 9965 10 , , , cord-005453-4057qib7 9965 11 an an DT cord-005453-4057qib7 9965 12 empirical empirical JJ cord-005453-4057qib7 9965 13 fungal fungal NN cord-005453-4057qib7 9965 14 treatment treatment NN cord-005453-4057qib7 9965 15 ( ( -LRB- cord-005453-4057qib7 9965 16 caspofungine caspofungine NNP cord-005453-4057qib7 9965 17 ) ) -RRB- cord-005453-4057qib7 9965 18 was be VBD cord-005453-4057qib7 9965 19 added add VBN cord-005453-4057qib7 9965 20 to to IN cord-005453-4057qib7 9965 21 empirical empirical JJ cord-005453-4057qib7 9965 22 antibiotics antibiotic NNS cord-005453-4057qib7 9965 23 . . . cord-005453-4057qib7 9966 1 As as RB cord-005453-4057qib7 9966 2 soon soon RB cord-005453-4057qib7 9966 3 as as IN cord-005453-4057qib7 9966 4 neutropenic neutropenic RB cord-005453-4057qib7 9966 5 recovered recover VBN cord-005453-4057qib7 9966 6 and and CC cord-005453-4057qib7 9966 7 in in IN cord-005453-4057qib7 9966 8 the the DT cord-005453-4057qib7 9966 9 case case NN cord-005453-4057qib7 9966 10 of of IN cord-005453-4057qib7 9966 11 apyrexia apyrexia NNS cord-005453-4057qib7 9966 12 without without IN cord-005453-4057qib7 9966 13 microbiologic microbiologic NNP cord-005453-4057qib7 9966 14 documentation documentation NN cord-005453-4057qib7 9966 15 , , , cord-005453-4057qib7 9966 16 antimicrobial antimicrobial JJ cord-005453-4057qib7 9966 17 treatments treatment NNS cord-005453-4057qib7 9966 18 were be VBD cord-005453-4057qib7 9966 19 stopped stop VBN cord-005453-4057qib7 9966 20 while while IN cord-005453-4057qib7 9966 21 in in IN cord-005453-4057qib7 9966 22 the the DT cord-005453-4057qib7 9966 23 case case NN cord-005453-4057qib7 9966 24 of of IN cord-005453-4057qib7 9966 25 microbiologic microbiologic JJ cord-005453-4057qib7 9966 26 documentation documentation NN cord-005453-4057qib7 9966 27 , , , cord-005453-4057qib7 9966 28 treatments treatment NNS cord-005453-4057qib7 9966 29 were be VBD cord-005453-4057qib7 9966 30 adjusted adjust VBN cord-005453-4057qib7 9966 31 to to IN cord-005453-4057qib7 9966 32 germ germ NN cord-005453-4057qib7 9966 33 in in IN cord-005453-4057qib7 9966 34 term term NN cord-005453-4057qib7 9966 35 of of IN cord-005453-4057qib7 9966 36 dosing dosing NN cord-005453-4057qib7 9966 37 and and CC cord-005453-4057qib7 9966 38 time time NN cord-005453-4057qib7 9966 39 of of IN cord-005453-4057qib7 9966 40 administration administration NN cord-005453-4057qib7 9966 41 following follow VBG cord-005453-4057qib7 9966 42 recommendations recommendation NNS cord-005453-4057qib7 9966 43 . . . cord-005453-4057qib7 9967 1 However however RB cord-005453-4057qib7 9967 2 , , , cord-005453-4057qib7 9967 3 some some DT cord-005453-4057qib7 9967 4 patients patient NNS cord-005453-4057qib7 9967 5 received receive VBD cord-005453-4057qib7 9967 6 antifungal antifungal JJ cord-005453-4057qib7 9967 7 azole azole NNP cord-005453-4057qib7 9967 8 prophylaxis prophylaxis NN cord-005453-4057qib7 9967 9 during during IN cord-005453-4057qib7 9967 10 the the DT cord-005453-4057qib7 9967 11 neutropenic neutropenic JJ cord-005453-4057qib7 9967 12 pre pre JJ cord-005453-4057qib7 9967 13 - - JJ cord-005453-4057qib7 9967 14 engraftment engraftment JJ cord-005453-4057qib7 9967 15 period period NN cord-005453-4057qib7 9967 16 in in IN cord-005453-4057qib7 9967 17 case case NN cord-005453-4057qib7 9967 18 of of IN cord-005453-4057qib7 9967 19 history history NN cord-005453-4057qib7 9967 20 of of IN cord-005453-4057qib7 9967 21 previous previous JJ cord-005453-4057qib7 9967 22 invasive invasive JJ cord-005453-4057qib7 9967 23 aspergillosis aspergillosis NN cord-005453-4057qib7 9967 24 ( ( -LRB- cord-005453-4057qib7 9967 25 IA IA NNP cord-005453-4057qib7 9967 26 ) ) -RRB- cord-005453-4057qib7 9967 27 , , , cord-005453-4057qib7 9967 28 or or CC cord-005453-4057qib7 9967 29 a a DT cord-005453-4057qib7 9967 30 nasal nasal JJ cord-005453-4057qib7 9967 31 colonization colonization NN cord-005453-4057qib7 9967 32 by by IN cord-005453-4057qib7 9967 33 Aspergillus Aspergillus NNP cord-005453-4057qib7 9967 34 . . . cord-005453-4057qib7 9968 1 In in IN cord-005453-4057qib7 9968 2 post post JJ cord-005453-4057qib7 9968 3 - - JJ cord-005453-4057qib7 9968 4 engraftment engraftment JJ cord-005453-4057qib7 9968 5 period period NN cord-005453-4057qib7 9968 6 , , , cord-005453-4057qib7 9968 7 posaconasole posaconasole NN cord-005453-4057qib7 9968 8 prophylaxis prophylaxis NN cord-005453-4057qib7 9968 9 was be VBD cord-005453-4057qib7 9968 10 administered administer VBN cord-005453-4057qib7 9968 11 for for IN cord-005453-4057qib7 9968 12 patients patient NNS cord-005453-4057qib7 9968 13 with with IN cord-005453-4057qib7 9968 14 systemic systemic JJ cord-005453-4057qib7 9968 15 corticotherapy corticotherapy NN cord-005453-4057qib7 9968 16 for for IN cord-005453-4057qib7 9968 17 acute acute JJ cord-005453-4057qib7 9968 18 graft graft NN cord-005453-4057qib7 9968 19 - - HYPH cord-005453-4057qib7 9968 20 versus versus IN cord-005453-4057qib7 9968 21 - - HYPH cord-005453-4057qib7 9968 22 host host NN cord-005453-4057qib7 9968 23 disease disease NN cord-005453-4057qib7 9968 24 . . . cord-005453-4057qib7 9969 1 Results result NNS cord-005453-4057qib7 9969 2 : : : cord-005453-4057qib7 9970 1 91 91 CD cord-005453-4057qib7 9970 2 patients patient NNS cord-005453-4057qib7 9970 3 were be VBD cord-005453-4057qib7 9970 4 evaluated evaluate VBN cord-005453-4057qib7 9970 5 ( ( -LRB- cord-005453-4057qib7 9970 6 median median JJ cord-005453-4057qib7 9970 7 [ [ -LRB- cord-005453-4057qib7 9970 8 min min NNP cord-005453-4057qib7 9970 9 - - HYPH cord-005453-4057qib7 9970 10 max max NNP cord-005453-4057qib7 9970 11 ] ] -RRB- cord-005453-4057qib7 9970 12 age age NN cord-005453-4057qib7 9970 13 of of IN cord-005453-4057qib7 9970 14 60 60 CD cord-005453-4057qib7 9970 15 [ [ -LRB- cord-005453-4057qib7 9970 16 33 33 CD cord-005453-4057qib7 9970 17 - - SYM cord-005453-4057qib7 9970 18 71 71 CD cord-005453-4057qib7 9970 19 ] ] -RRB- cord-005453-4057qib7 9970 20 years year NNS cord-005453-4057qib7 9970 21 ) ) -RRB- cord-005453-4057qib7 9970 22 . . . cord-005453-4057qib7 9971 1 20 20 CD cord-005453-4057qib7 9971 2 % % NN cord-005453-4057qib7 9971 3 of of IN cord-005453-4057qib7 9971 4 patients patient NNS cord-005453-4057qib7 9971 5 received receive VBD cord-005453-4057qib7 9971 6 an an DT cord-005453-4057qib7 9971 7 HLAidentical HLAidentical NNP cord-005453-4057qib7 9971 8 related related JJ cord-005453-4057qib7 9971 9 donor donor NN cord-005453-4057qib7 9971 10 , , , cord-005453-4057qib7 9971 11 69 69 CD cord-005453-4057qib7 9971 12 % % NN cord-005453-4057qib7 9971 13 an an DT cord-005453-4057qib7 9971 14 HLA HLA NNP cord-005453-4057qib7 9971 15 - - HYPH cord-005453-4057qib7 9971 16 matched match VBN cord-005453-4057qib7 9971 17 related related JJ cord-005453-4057qib7 9971 18 donor donor NN cord-005453-4057qib7 9971 19 and and CC cord-005453-4057qib7 9971 20 11 11 CD cord-005453-4057qib7 9971 21 % % NN cord-005453-4057qib7 9971 22 an an DT cord-005453-4057qib7 9971 23 HLA HLA NNP cord-005453-4057qib7 9971 24 - - HYPH cord-005453-4057qib7 9971 25 mismatched mismatch VBN cord-005453-4057qib7 9971 26 unrelated unrelated JJ cord-005453-4057qib7 9971 27 donor donor NN cord-005453-4057qib7 9971 28 . . . cord-005453-4057qib7 9972 1 The the DT cord-005453-4057qib7 9972 2 five five CD cord-005453-4057qib7 9972 3 years year NNS cord-005453-4057qib7 9972 4 overall overall JJ cord-005453-4057qib7 9972 5 survival survival NN cord-005453-4057qib7 9972 6 and and CC cord-005453-4057qib7 9972 7 survival survival NN cord-005453-4057qib7 9972 8 without without IN cord-005453-4057qib7 9972 9 relapse relapse NN cord-005453-4057qib7 9972 10 or or CC cord-005453-4057qib7 9972 11 GvHD GvHD NNP cord-005453-4057qib7 9972 12 were be VBD cord-005453-4057qib7 9972 13 70 70 CD cord-005453-4057qib7 9972 14 % % NN cord-005453-4057qib7 9973 1 IC95 IC95 NNP cord-005453-4057qib7 9973 2 [ [ -LRB- cord-005453-4057qib7 9973 3 59%-81 59%-81 CD cord-005453-4057qib7 9973 4 % % NN cord-005453-4057qib7 9973 5 ] ] -RRB- cord-005453-4057qib7 9973 6 and and CC cord-005453-4057qib7 9973 7 62 62 CD cord-005453-4057qib7 9973 8 % % NN cord-005453-4057qib7 9973 9 respectively respectively RB cord-005453-4057qib7 9973 10 IC IC NNP cord-005453-4057qib7 9973 11 95 95 CD cord-005453-4057qib7 9973 12 [ [ -LRB- cord-005453-4057qib7 9973 13 52%-73 52%-73 CD cord-005453-4057qib7 9973 14 % % NN cord-005453-4057qib7 9973 15 ] ] -RRB- cord-005453-4057qib7 9973 16 . . . cord-005453-4057qib7 9974 1 The the DT cord-005453-4057qib7 9974 2 median median JJ cord-005453-4057qib7 9974 3 time time NN cord-005453-4057qib7 9974 4 for for IN cord-005453-4057qib7 9974 5 neutrophil neutrophil NN cord-005453-4057qib7 9974 6 recovery recovery NN cord-005453-4057qib7 9974 7 was be VBD cord-005453-4057qib7 9974 8 15 15 CD cord-005453-4057qib7 9974 9 days day NNS cord-005453-4057qib7 9974 10 . . . cord-005453-4057qib7 9975 1 79 79 CD cord-005453-4057qib7 9975 2 patients patient NNS cord-005453-4057qib7 9975 3 did do VBD cord-005453-4057qib7 9975 4 not not RB cord-005453-4057qib7 9975 5 receive receive VB cord-005453-4057qib7 9975 6 prophylaxis prophylaxis NN cord-005453-4057qib7 9975 7 and and CC cord-005453-4057qib7 9975 8 only only RB cord-005453-4057qib7 9975 9 12 12 CD cord-005453-4057qib7 9975 10 patients patient NNS cord-005453-4057qib7 9975 11 received receive VBD cord-005453-4057qib7 9975 12 systematic systematic JJ cord-005453-4057qib7 9975 13 fungal fungal NN cord-005453-4057qib7 9975 14 azole azole NNP cord-005453-4057qib7 9975 15 prophylaxis prophylaxis NN cord-005453-4057qib7 9975 16 in in IN cord-005453-4057qib7 9975 17 the the DT cord-005453-4057qib7 9975 18 pre pre JJ cord-005453-4057qib7 9975 19 - - JJ cord-005453-4057qib7 9975 20 engraftment engraftment JJ cord-005453-4057qib7 9975 21 period period NN cord-005453-4057qib7 9975 22 . . . cord-005453-4057qib7 9976 1 Two two CD cord-005453-4057qib7 9976 2 patients patient NNS cord-005453-4057qib7 9976 3 received receive VBD cord-005453-4057qib7 9976 4 an an DT cord-005453-4057qib7 9976 5 empirical empirical JJ cord-005453-4057qib7 9976 6 treatment treatment NN cord-005453-4057qib7 9976 7 by by IN cord-005453-4057qib7 9976 8 caspofungine caspofungine NNP cord-005453-4057qib7 9976 9 . . . cord-005453-4057qib7 9977 1 Only only RB cord-005453-4057qib7 9977 2 1 1 CD cord-005453-4057qib7 9977 3 IFI IFI NNP cord-005453-4057qib7 9977 4 was be VBD cord-005453-4057qib7 9977 5 documented document VBN cord-005453-4057qib7 9977 6 during during IN cord-005453-4057qib7 9977 7 the the DT cord-005453-4057qib7 9977 8 neutropenic neutropenic JJ cord-005453-4057qib7 9977 9 period period NN cord-005453-4057qib7 9977 10 : : : cord-005453-4057qib7 9977 11 candida candida NNP cord-005453-4057qib7 9977 12 krusei krusei NNP cord-005453-4057qib7 9977 13 in in IN cord-005453-4057qib7 9977 14 blood blood NN cord-005453-4057qib7 9977 15 culture culture NN cord-005453-4057qib7 9977 16 . . . cord-005453-4057qib7 9978 1 In in IN cord-005453-4057qib7 9978 2 the the DT cord-005453-4057qib7 9978 3 post post JJ cord-005453-4057qib7 9978 4 engraftment engraftment NN cord-005453-4057qib7 9978 5 period period NN cord-005453-4057qib7 9978 6 , , , cord-005453-4057qib7 9978 7 37 37 CD cord-005453-4057qib7 9978 8 patients patient NNS cord-005453-4057qib7 9978 9 with with IN cord-005453-4057qib7 9978 10 acute acute JJ cord-005453-4057qib7 9978 11 GVHD GVHD NNP cord-005453-4057qib7 9978 12 treated treat VBN cord-005453-4057qib7 9978 13 by by IN cord-005453-4057qib7 9978 14 corticotherapy corticotherapy NNP cord-005453-4057qib7 9978 15 received receive VBD cord-005453-4057qib7 9978 16 an an DT cord-005453-4057qib7 9978 17 antifungal antifungal JJ cord-005453-4057qib7 9978 18 prophylaxis prophylaxis NN cord-005453-4057qib7 9978 19 by by IN cord-005453-4057qib7 9978 20 posaconazole posaconazole NN cord-005453-4057qib7 9978 21 and and CC cord-005453-4057qib7 9978 22 only only RB cord-005453-4057qib7 9978 23 1 1 CD cord-005453-4057qib7 9978 24 patient patient NN cord-005453-4057qib7 9978 25 had have VBD cord-005453-4057qib7 9978 26 a a DT cord-005453-4057qib7 9978 27 probable probable JJ cord-005453-4057qib7 9978 28 IA IA NNP cord-005453-4057qib7 9978 29 at at IN cord-005453-4057qib7 9978 30 day day NN cord-005453-4057qib7 9978 31 100 100 CD cord-005453-4057qib7 9978 32 despite despite IN cord-005453-4057qib7 9978 33 prophylaxis prophylaxis NN cord-005453-4057qib7 9978 34 by by IN cord-005453-4057qib7 9978 35 posaconasole posaconasole NN cord-005453-4057qib7 9978 36 . . . cord-005453-4057qib7 9979 1 Conclusions conclusion NNS cord-005453-4057qib7 9979 2 : : : cord-005453-4057qib7 9980 1 Except except IN cord-005453-4057qib7 9980 2 for for IN cord-005453-4057qib7 9980 3 patients patient NNS cord-005453-4057qib7 9980 4 with with IN cord-005453-4057qib7 9980 5 previous previous JJ cord-005453-4057qib7 9980 6 history history NN cord-005453-4057qib7 9980 7 of of IN cord-005453-4057qib7 9980 8 IFI IFI NNP cord-005453-4057qib7 9980 9 , , , cord-005453-4057qib7 9980 10 our -PRON- PRP$ cord-005453-4057qib7 9980 11 results result NNS cord-005453-4057qib7 9980 12 provide provide VBP cord-005453-4057qib7 9980 13 additional additional JJ cord-005453-4057qib7 9980 14 arguments argument NNS cord-005453-4057qib7 9980 15 against against IN cord-005453-4057qib7 9980 16 systematic systematic JJ cord-005453-4057qib7 9980 17 fungal fungal JJ cord-005453-4057qib7 9980 18 prophylaxis prophylaxis NN cord-005453-4057qib7 9980 19 after after IN cord-005453-4057qib7 9980 20 reduced reduce VBN cord-005453-4057qib7 9980 21 intensity intensity NN cord-005453-4057qib7 9980 22 conditioning conditioning NN cord-005453-4057qib7 9980 23 with with IN cord-005453-4057qib7 9980 24 PBSC PBSC NNP cord-005453-4057qib7 9980 25 allogenic allogenic JJ cord-005453-4057qib7 9980 26 transplantation transplantation NN cord-005453-4057qib7 9980 27 in in IN cord-005453-4057qib7 9980 28 the the DT cord-005453-4057qib7 9980 29 pre pre JJ cord-005453-4057qib7 9980 30 - - JJ cord-005453-4057qib7 9980 31 engraftment engraftment JJ cord-005453-4057qib7 9980 32 period period NN cord-005453-4057qib7 9980 33 with with IN cord-005453-4057qib7 9980 34 a a DT cord-005453-4057qib7 9980 35 very very RB cord-005453-4057qib7 9980 36 low low JJ cord-005453-4057qib7 9980 37 incidence incidence NN cord-005453-4057qib7 9980 38 of of IN cord-005453-4057qib7 9980 39 invasive invasive JJ cord-005453-4057qib7 9980 40 fungal fungal JJ cord-005453-4057qib7 9980 41 infections infection NNS cord-005453-4057qib7 9980 42 . . . cord-005453-4057qib7 9981 1 In in IN cord-005453-4057qib7 9981 2 post post JJ cord-005453-4057qib7 9981 3 - - JJ cord-005453-4057qib7 9981 4 engrafment engrafment JJ cord-005453-4057qib7 9981 5 period period NN cord-005453-4057qib7 9981 6 , , , cord-005453-4057qib7 9981 7 posaconazole posaconazole NNP cord-005453-4057qib7 9981 8 prophylaxis prophylaxis NN cord-005453-4057qib7 9981 9 is be VBZ cord-005453-4057qib7 9981 10 required require VBN cord-005453-4057qib7 9981 11 for for IN cord-005453-4057qib7 9981 12 patient patient NN cord-005453-4057qib7 9981 13 with with IN cord-005453-4057qib7 9981 14 GVHD GVHD NNP cord-005453-4057qib7 9981 15 treated treat VBN cord-005453-4057qib7 9981 16 by by IN cord-005453-4057qib7 9981 17 corticotherapy corticotherapy NNP cord-005453-4057qib7 9981 18 . . . cord-005453-4057qib7 9982 1 Disclosure disclosure NN cord-005453-4057qib7 9982 2 Methods method NNS cord-005453-4057qib7 9982 3 : : : cord-005453-4057qib7 9983 1 A a DT cord-005453-4057qib7 9983 2 simple simple JJ cord-005453-4057qib7 9983 3 , , , cord-005453-4057qib7 9983 4 rapid rapid JJ cord-005453-4057qib7 9983 5 and and CC cord-005453-4057qib7 9983 6 sensitive sensitive JJ cord-005453-4057qib7 9983 7 method method NN cord-005453-4057qib7 9983 8 using use VBG cord-005453-4057qib7 9983 9 HPLC HPLC NNP cord-005453-4057qib7 9983 10 with with IN cord-005453-4057qib7 9983 11 a a DT cord-005453-4057qib7 9983 12 diode diode NN cord-005453-4057qib7 9983 13 - - HYPH cord-005453-4057qib7 9983 14 array array NN cord-005453-4057qib7 9983 15 detector detector NN cord-005453-4057qib7 9983 16 ( ( -LRB- cord-005453-4057qib7 9983 17 DAD DAD NNP cord-005453-4057qib7 9983 18 ) ) -RRB- cord-005453-4057qib7 9983 19 was be VBD cord-005453-4057qib7 9983 20 developed develop VBN cord-005453-4057qib7 9983 21 and and CC cord-005453-4057qib7 9983 22 validated validate VBN cord-005453-4057qib7 9983 23 for for IN cord-005453-4057qib7 9983 24 the the DT cord-005453-4057qib7 9983 25 quantification quantification NN cord-005453-4057qib7 9983 26 of of IN cord-005453-4057qib7 9983 27 Letermovir Letermovir NNP cord-005453-4057qib7 9983 28 in in IN cord-005453-4057qib7 9983 29 human human JJ cord-005453-4057qib7 9983 30 serum serum NN cord-005453-4057qib7 9983 31 using use VBG cord-005453-4057qib7 9983 32 Sorafenib Sorafenib NNP cord-005453-4057qib7 9983 33 as as IN cord-005453-4057qib7 9983 34 internal internal JJ cord-005453-4057qib7 9983 35 standard standard NN cord-005453-4057qib7 9983 36 . . . cord-005453-4057qib7 9984 1 After after IN cord-005453-4057qib7 9984 2 pretreating pretreate VBG cord-005453-4057qib7 9984 3 serum serum NN cord-005453-4057qib7 9984 4 samples sample NNS cord-005453-4057qib7 9984 5 by by IN cord-005453-4057qib7 9984 6 liquid liquid NN cord-005453-4057qib7 9984 7 - - HYPH cord-005453-4057qib7 9984 8 liquid liquid NN cord-005453-4057qib7 9984 9 extraction extraction NN cord-005453-4057qib7 9984 10 with with IN cord-005453-4057qib7 9984 11 tert tert NNP cord-005453-4057qib7 9984 12 - - HYPH cord-005453-4057qib7 9984 13 Butyl butyl NN cord-005453-4057qib7 9984 14 methyl methyl NN cord-005453-4057qib7 9984 15 ether ether NN cord-005453-4057qib7 9984 16 , , , cord-005453-4057qib7 9984 17 separation separation NN cord-005453-4057qib7 9984 18 was be VBD cord-005453-4057qib7 9984 19 achieved achieve VBN cord-005453-4057qib7 9984 20 on on IN cord-005453-4057qib7 9984 21 a a DT cord-005453-4057qib7 9984 22 X x NN cord-005453-4057qib7 9984 23 - - NNP cord-005453-4057qib7 9984 24 Terra Terra NNP cord-005453-4057qib7 9984 25 RP-18 RP-18 NNP cord-005453-4057qib7 9984 26 column column NN cord-005453-4057qib7 9984 27 ( ( -LRB- cord-005453-4057qib7 9984 28 Dimension dimension NN cord-005453-4057qib7 9984 29 150 150 CD cord-005453-4057qib7 9984 30 x x SYM cord-005453-4057qib7 9984 31 2.1 2.1 CD cord-005453-4057qib7 9984 32 mm mm NN cord-005453-4057qib7 9984 33 , , , cord-005453-4057qib7 9984 34 5μm 5μm NN cord-005453-4057qib7 9984 35 ) ) -RRB- cord-005453-4057qib7 9984 36 at at IN cord-005453-4057qib7 9984 37 30 30 CD cord-005453-4057qib7 9984 38 0 0 CD cord-005453-4057qib7 9984 39 C c NN cord-005453-4057qib7 9984 40 using use VBG cord-005453-4057qib7 9984 41 gradient gradient NN cord-005453-4057qib7 9984 42 elution elution NN cord-005453-4057qib7 9984 43 with with IN cord-005453-4057qib7 9984 44 a a DT cord-005453-4057qib7 9984 45 mobile mobile JJ cord-005453-4057qib7 9984 46 phase phase NN cord-005453-4057qib7 9984 47 of of IN cord-005453-4057qib7 9984 48 20 20 CD cord-005453-4057qib7 9984 49 mM mm CD cord-005453-4057qib7 9984 50 ammonium ammonium NN cord-005453-4057qib7 9984 51 bicarbonate bicarbonate NN cord-005453-4057qib7 9984 52 pH pH NNP cord-005453-4057qib7 9984 53 7.8 7.8 CD cord-005453-4057qib7 9984 54 ( ( -LRB- cord-005453-4057qib7 9984 55 mobile mobile JJ cord-005453-4057qib7 9984 56 phase phase NN cord-005453-4057qib7 9984 57 solvent solvent NN cord-005453-4057qib7 9984 58 - - : cord-005453-4057qib7 9984 59 A a NN cord-005453-4057qib7 9984 60 ) ) -RRB- cord-005453-4057qib7 9984 61 and and CC cord-005453-4057qib7 9984 62 acetonitrile:20mM acetonitrile:20mm CD cord-005453-4057qib7 9984 63 ammonium ammonium NN cord-005453-4057qib7 9984 64 bicarbonate bicarbonate NN cord-005453-4057qib7 9984 65 pH pH NNP cord-005453-4057qib7 9984 66 9.2 9.2 CD cord-005453-4057qib7 9984 67 ( ( -LRB- cord-005453-4057qib7 9984 68 mobile mobile JJ cord-005453-4057qib7 9984 69 phase phase NN cord-005453-4057qib7 9984 70 solvent solvent NN cord-005453-4057qib7 9984 71 - - HYPH cord-005453-4057qib7 9984 72 B b NN cord-005453-4057qib7 9984 73 ) ) -RRB- cord-005453-4057qib7 9984 74 . . . cord-005453-4057qib7 9985 1 Samples sample NNS cord-005453-4057qib7 9985 2 were be VBD cord-005453-4057qib7 9985 3 eluted elute VBN cord-005453-4057qib7 9985 4 at at IN cord-005453-4057qib7 9985 5 a a DT cord-005453-4057qib7 9985 6 flow flow NN cord-005453-4057qib7 9985 7 rate rate NN cord-005453-4057qib7 9985 8 of of IN cord-005453-4057qib7 9985 9 0.3ml 0.3ml CD cord-005453-4057qib7 9985 10 / / SYM cord-005453-4057qib7 9985 11 min min NN cord-005453-4057qib7 9985 12 throughout throughout IN cord-005453-4057qib7 9985 13 the the DT cord-005453-4057qib7 9985 14 20-minute 20-minute JJ cord-005453-4057qib7 9985 15 run run NN cord-005453-4057qib7 9985 16 . . . cord-005453-4057qib7 9986 1 UV uv NN cord-005453-4057qib7 9986 2 wavelength wavelength NN cord-005453-4057qib7 9986 3 mode mode NN cord-005453-4057qib7 9986 4 was be VBD cord-005453-4057qib7 9986 5 used use VBN cord-005453-4057qib7 9986 6 , , , cord-005453-4057qib7 9986 7 detection detection NN cord-005453-4057qib7 9986 8 was be VBD cord-005453-4057qib7 9986 9 at at IN cord-005453-4057qib7 9986 10 260 260 CD cord-005453-4057qib7 9986 11 nm nm NN cord-005453-4057qib7 9986 12 . . . cord-005453-4057qib7 9987 1 Results result NNS cord-005453-4057qib7 9987 2 : : : cord-005453-4057qib7 9988 1 The the DT cord-005453-4057qib7 9988 2 calibration calibration NN cord-005453-4057qib7 9988 3 curve curve NN cord-005453-4057qib7 9988 4 was be VBD cord-005453-4057qib7 9988 5 linear linear JJ cord-005453-4057qib7 9988 6 ( ( -LRB- cord-005453-4057qib7 9988 7 r r NN cord-005453-4057qib7 9988 8 > > XX cord-005453-4057qib7 9988 9 0.99 0.99 CD cord-005453-4057qib7 9988 10 ) ) -RRB- cord-005453-4057qib7 9988 11 in in IN cord-005453-4057qib7 9988 12 a a DT cord-005453-4057qib7 9988 13 concentration concentration NN cord-005453-4057qib7 9988 14 range range NN cord-005453-4057qib7 9988 15 of of IN cord-005453-4057qib7 9988 16 25 25 CD cord-005453-4057qib7 9988 17 -5000 -5000 NNS cord-005453-4057qib7 9988 18 ng ng NN cord-005453-4057qib7 9988 19 / / SYM cord-005453-4057qib7 9988 20 ml ml NN cord-005453-4057qib7 9988 21 for for IN cord-005453-4057qib7 9988 22 Letermovir Letermovir NNP cord-005453-4057qib7 9988 23 . . . cord-005453-4057qib7 9989 1 The the DT cord-005453-4057qib7 9989 2 HPLC HPLC NNP cord-005453-4057qib7 9989 3 assay assay NN cord-005453-4057qib7 9989 4 established establish VBN cord-005453-4057qib7 9989 5 for for IN cord-005453-4057qib7 9989 6 Letermovir Letermovir NNP cord-005453-4057qib7 9989 7 determination determination NN cord-005453-4057qib7 9989 8 showed show VBD cord-005453-4057qib7 9989 9 a a DT cord-005453-4057qib7 9989 10 high high JJ cord-005453-4057qib7 9989 11 rate rate NN cord-005453-4057qib7 9989 12 of of IN cord-005453-4057qib7 9989 13 accuracy accuracy NN cord-005453-4057qib7 9989 14 and and CC cord-005453-4057qib7 9989 15 precision precision NN cord-005453-4057qib7 9989 16 with with IN cord-005453-4057qib7 9989 17 an an DT cord-005453-4057qib7 9989 18 intraday intraday NN cord-005453-4057qib7 9989 19 variability variability NN cord-005453-4057qib7 9989 20 of of IN cord-005453-4057qib7 9989 21 -9.21 -9.21 CD cord-005453-4057qib7 9989 22 to to IN cord-005453-4057qib7 9989 23 12 12 CD cord-005453-4057qib7 9989 24 % % NN cord-005453-4057qib7 9989 25 ( ( -LRB- cord-005453-4057qib7 9989 26 accuracy accuracy NN cord-005453-4057qib7 9989 27 ) ) -RRB- cord-005453-4057qib7 9989 28 and and CC cord-005453-4057qib7 9989 29 0.31 0.31 CD cord-005453-4057qib7 9989 30 to to TO cord-005453-4057qib7 9989 31 3.75 3.75 CD cord-005453-4057qib7 9989 32 % % NN cord-005453-4057qib7 9989 33 ( ( -LRB- cord-005453-4057qib7 9989 34 precision precision NN cord-005453-4057qib7 9989 35 ) ) -RRB- cord-005453-4057qib7 9989 36 and and CC cord-005453-4057qib7 9989 37 an an DT cord-005453-4057qib7 9989 38 interday interday NN cord-005453-4057qib7 9989 39 variability variability NN cord-005453-4057qib7 9989 40 of of IN cord-005453-4057qib7 9989 41 -2.6 -2.6 NN cord-005453-4057qib7 9989 42 to to IN cord-005453-4057qib7 9989 43 6.9 6.9 CD cord-005453-4057qib7 9989 44 % % NN cord-005453-4057qib7 9989 45 ( ( -LRB- cord-005453-4057qib7 9989 46 accuracy accuracy NN cord-005453-4057qib7 9989 47 ) ) -RRB- cord-005453-4057qib7 9989 48 and and CC cord-005453-4057qib7 9989 49 3.74 3.74 CD cord-005453-4057qib7 9989 50 to to TO cord-005453-4057qib7 9989 51 7.41 7.41 CD cord-005453-4057qib7 9989 52 % % NN cord-005453-4057qib7 9989 53 ( ( -LRB- cord-005453-4057qib7 9989 54 precision precision NN cord-005453-4057qib7 9989 55 ) ) -RRB- cord-005453-4057qib7 9989 56 , , , cord-005453-4057qib7 9989 57 respectively respectively RB cord-005453-4057qib7 9989 58 . . . cord-005453-4057qib7 9990 1 16 16 CD cord-005453-4057qib7 9991 1 Letermovir Letermovir NNP cord-005453-4057qib7 9991 2 serum serum NN cord-005453-4057qib7 9991 3 concentrations concentration NNS cord-005453-4057qib7 9991 4 of of IN cord-005453-4057qib7 9991 5 9 9 CD cord-005453-4057qib7 9991 6 patients patient NNS cord-005453-4057qib7 9991 7 ( ( -LRB- cord-005453-4057qib7 9991 8 8 8 CD cord-005453-4057qib7 9991 9 male male JJ cord-005453-4057qib7 9991 10 / / SYM cord-005453-4057qib7 9991 11 1 1 CD cord-005453-4057qib7 9991 12 female female NN cord-005453-4057qib7 9991 13 , , , cord-005453-4057qib7 9991 14 mean mean VB cord-005453-4057qib7 9991 15 age age NN cord-005453-4057qib7 9991 16 66.3 66.3 CD cord-005453-4057qib7 9991 17 years year NNS cord-005453-4057qib7 9991 18 ) ) -RRB- cord-005453-4057qib7 9991 19 were be VBD cord-005453-4057qib7 9991 20 determined determine VBN cord-005453-4057qib7 9991 21 in in IN cord-005453-4057qib7 9991 22 daily daily JJ cord-005453-4057qib7 9991 23 clinical clinical JJ cord-005453-4057qib7 9991 24 practice practice NN cord-005453-4057qib7 9991 25 . . . cord-005453-4057qib7 9992 1 The the DT cord-005453-4057qib7 9992 2 mean mean JJ cord-005453-4057qib7 9992 3 concentration concentration NN cord-005453-4057qib7 9992 4 was be VBD cord-005453-4057qib7 9992 5 4752 4752 CD cord-005453-4057qib7 9992 6 ng ng NNP cord-005453-4057qib7 9992 7 / / SYM cord-005453-4057qib7 9992 8 ml ml NN cord-005453-4057qib7 9992 9 ( ( -LRB- cord-005453-4057qib7 9992 10 median median JJ cord-005453-4057qib7 9992 11 4163 4163 CD cord-005453-4057qib7 9992 12 ng ng NNP cord-005453-4057qib7 9992 13 / / SYM cord-005453-4057qib7 9992 14 ml ml NN cord-005453-4057qib7 9992 15 , , , cord-005453-4057qib7 9992 16 standard standard JJ cord-005453-4057qib7 9992 17 deviation deviation NN cord-005453-4057qib7 9992 18 3925 3925 CD cord-005453-4057qib7 9992 19 ng ng NNP cord-005453-4057qib7 9992 20 / / SYM cord-005453-4057qib7 9992 21 ml ml XX cord-005453-4057qib7 9992 22 , , , cord-005453-4057qib7 9993 1 range range VBP cord-005453-4057qib7 9993 2 89 89 CD cord-005453-4057qib7 9994 1 -11452 -11452 : cord-005453-4057qib7 9994 2 ng ng NNP cord-005453-4057qib7 9994 3 / / SYM cord-005453-4057qib7 9994 4 ml ml NN cord-005453-4057qib7 9994 5 ) ) -RRB- cord-005453-4057qib7 9994 6 . . . cord-005453-4057qib7 9995 1 Conclusions conclusion NNS cord-005453-4057qib7 9995 2 : : : cord-005453-4057qib7 9996 1 The the DT cord-005453-4057qib7 9996 2 newly newly RB cord-005453-4057qib7 9996 3 developed develop VBN cord-005453-4057qib7 9996 4 HPLC HPLC NNP cord-005453-4057qib7 9996 5 method method NN cord-005453-4057qib7 9996 6 is be VBZ cord-005453-4057qib7 9996 7 useful useful JJ cord-005453-4057qib7 9996 8 for for IN cord-005453-4057qib7 9996 9 the the DT cord-005453-4057qib7 9996 10 determination determination NN cord-005453-4057qib7 9996 11 of of IN cord-005453-4057qib7 9996 12 Letermovir Letermovir NNP cord-005453-4057qib7 9996 13 concentrations concentration NNS cord-005453-4057qib7 9996 14 . . . cord-005453-4057qib7 9997 1 Patient patient NN cord-005453-4057qib7 9997 2 samples sample NNS cord-005453-4057qib7 9997 3 analyzed analyze VBN cord-005453-4057qib7 9997 4 in in IN cord-005453-4057qib7 9997 5 a a DT cord-005453-4057qib7 9997 6 routine routine JJ cord-005453-4057qib7 9997 7 clinical clinical JJ cord-005453-4057qib7 9997 8 setting setting NN cord-005453-4057qib7 9997 9 demonstrated demonstrate VBD cord-005453-4057qib7 9997 10 considerable considerable JJ cord-005453-4057qib7 9997 11 interindividual interindividual JJ cord-005453-4057qib7 9997 12 variability variability NN cord-005453-4057qib7 9997 13 . . . cord-005453-4057qib7 9998 1 All all DT cord-005453-4057qib7 9998 2 measured measure VBN cord-005453-4057qib7 9998 3 concentrations concentration NNS cord-005453-4057qib7 9998 4 were be VBD cord-005453-4057qib7 9998 5 above above IN cord-005453-4057qib7 9998 6 the the DT cord-005453-4057qib7 9998 7 EC50 EC50 NNP cord-005453-4057qib7 9998 8 of of IN cord-005453-4057qib7 9998 9 Letermovir Letermovir NNP cord-005453-4057qib7 9998 10 . . . cord-005453-4057qib7 9999 1 Monitoring monitor VBG cord-005453-4057qib7 9999 2 the the DT cord-005453-4057qib7 9999 3 concentration concentration NN cord-005453-4057qib7 9999 4 of of IN cord-005453-4057qib7 9999 5 Letermovir Letermovir NNP cord-005453-4057qib7 9999 6 could could MD cord-005453-4057qib7 9999 7 help help VB cord-005453-4057qib7 9999 8 to to TO cord-005453-4057qib7 9999 9 prevent prevent VB cord-005453-4057qib7 9999 10 over over RP cord-005453-4057qib7 9999 11 - - HYPH cord-005453-4057qib7 9999 12 or or CC cord-005453-4057qib7 9999 13 underexposure underexposure NN cord-005453-4057qib7 9999 14 , , , cord-005453-4057qib7 9999 15 especially especially RB cord-005453-4057qib7 9999 16 in in IN cord-005453-4057qib7 9999 17 patients patient NNS cord-005453-4057qib7 9999 18 with with IN cord-005453-4057qib7 9999 19 polypharmacy polypharmacy NNS cord-005453-4057qib7 9999 20 which which WDT cord-005453-4057qib7 9999 21 is be VBZ cord-005453-4057qib7 9999 22 frequent frequent JJ cord-005453-4057qib7 9999 23 in in IN cord-005453-4057qib7 9999 24 allogeneic allogeneic JJ cord-005453-4057qib7 9999 25 hematopoietic hematopoietic JJ cord-005453-4057qib7 9999 26 stem stem NN cord-005453-4057qib7 9999 27 cell cell NN cord-005453-4057qib7 9999 28 transplant transplant NN cord-005453-4057qib7 9999 29 recipients recipient NNS cord-005453-4057qib7 9999 30 . . . cord-005453-4057qib7 10000 1 Disclosure disclosure NN cord-005453-4057qib7 10000 2 Background background NN cord-005453-4057qib7 10000 3 : : : cord-005453-4057qib7 10001 1 The the DT cord-005453-4057qib7 10001 2 use use NN cord-005453-4057qib7 10001 3 of of IN cord-005453-4057qib7 10001 4 preemptive preemptive JJ cord-005453-4057qib7 10001 5 strategy strategy NN cord-005453-4057qib7 10001 6 ( ( -LRB- cord-005453-4057qib7 10001 7 PET PET NNP cord-005453-4057qib7 10001 8 ) ) -RRB- cord-005453-4057qib7 10001 9 has have VBZ cord-005453-4057qib7 10001 10 lowered lower VBN cord-005453-4057qib7 10001 11 the the DT cord-005453-4057qib7 10001 12 incidence incidence NN cord-005453-4057qib7 10001 13 of of IN cord-005453-4057qib7 10001 14 CMV CMV NNP cord-005453-4057qib7 10001 15 disease disease NN cord-005453-4057qib7 10001 16 in in IN cord-005453-4057qib7 10001 17 allo allo NN cord-005453-4057qib7 10001 18 - - HYPH cord-005453-4057qib7 10001 19 SCT sct NN cord-005453-4057qib7 10001 20 to to IN cord-005453-4057qib7 10001 21 5 5 CD cord-005453-4057qib7 10001 22 - - SYM cord-005453-4057qib7 10001 23 10 10 CD cord-005453-4057qib7 10001 24 % % NN cord-005453-4057qib7 10001 25 . . . cord-005453-4057qib7 10002 1 Nonetheless nonetheless RB cord-005453-4057qib7 10002 2 the the DT cord-005453-4057qib7 10002 3 use use NN cord-005453-4057qib7 10002 4 of of IN cord-005453-4057qib7 10002 5 this this DT cord-005453-4057qib7 10002 6 strategy strategy NN cord-005453-4057qib7 10002 7 implies imply VBZ cord-005453-4057qib7 10002 8 that that IN cord-005453-4057qib7 10002 9 more more JJR cord-005453-4057qib7 10002 10 than than IN cord-005453-4057qib7 10002 11 50 50 CD cord-005453-4057qib7 10002 12 % % NN cord-005453-4057qib7 10002 13 of of IN cord-005453-4057qib7 10002 14 seropositive seropositive JJ cord-005453-4057qib7 10002 15 patients patient NNS cord-005453-4057qib7 10002 16 will will MD cord-005453-4057qib7 10002 17 replicate replicate VB cord-005453-4057qib7 10002 18 CMV CMV NNP cord-005453-4057qib7 10002 19 . . . cord-005453-4057qib7 10003 1 Several several JJ cord-005453-4057qib7 10003 2 studies study NNS cord-005453-4057qib7 10003 3 have have VBP cord-005453-4057qib7 10003 4 shown show VBN cord-005453-4057qib7 10003 5 that that IN cord-005453-4057qib7 10003 6 CMV CMV NNP cord-005453-4057qib7 10003 7 replication replication NN cord-005453-4057qib7 10003 8 is be VBZ cord-005453-4057qib7 10003 9 detrimental detrimental JJ cord-005453-4057qib7 10003 10 for for IN cord-005453-4057qib7 10003 11 patient patient JJ cord-005453-4057qib7 10003 12 survival survival NN cord-005453-4057qib7 10003 13 although although IN cord-005453-4057qib7 10003 14 the the DT cord-005453-4057qib7 10003 15 viral viral JJ cord-005453-4057qib7 10003 16 load load NN cord-005453-4057qib7 10003 17 related relate VBN cord-005453-4057qib7 10003 18 to to IN cord-005453-4057qib7 10003 19 this this DT cord-005453-4057qib7 10003 20 bad bad JJ cord-005453-4057qib7 10003 21 outcome outcome NN cord-005453-4057qib7 10003 22 variates variate NNS cord-005453-4057qib7 10003 23 among among IN cord-005453-4057qib7 10003 24 studies study NNS cord-005453-4057qib7 10003 25 . . . cord-005453-4057qib7 10004 1 Objective objective NN cord-005453-4057qib7 10004 2 : : : cord-005453-4057qib7 10005 1 To to TO cord-005453-4057qib7 10005 2 analyse analyse VB cord-005453-4057qib7 10005 3 thel thel NNP cord-005453-4057qib7 10005 4 impact impact NN cord-005453-4057qib7 10005 5 of of IN cord-005453-4057qib7 10005 6 CMV CMV NNP cord-005453-4057qib7 10005 7 replication replication NN cord-005453-4057qib7 10005 8 in in IN cord-005453-4057qib7 10005 9 overall overall JJ cord-005453-4057qib7 10005 10 survival survival NN cord-005453-4057qib7 10005 11 ( ( -LRB- cord-005453-4057qib7 10005 12 OS OS NNP cord-005453-4057qib7 10005 13 ) ) -RRB- cord-005453-4057qib7 10005 14 in in IN cord-005453-4057qib7 10005 15 allo allo NN cord-005453-4057qib7 10005 16 - - HYPH cord-005453-4057qib7 10005 17 HCT hct NN cord-005453-4057qib7 10005 18 patients patient NNS cord-005453-4057qib7 10005 19 . . . cord-005453-4057qib7 10006 1 Methods method NNS cord-005453-4057qib7 10006 2 : : : cord-005453-4057qib7 10006 3 To to TO cord-005453-4057qib7 10006 4 analyse analyse VB cord-005453-4057qib7 10006 5 the the DT cord-005453-4057qib7 10006 6 impact impact NN cord-005453-4057qib7 10006 7 of of IN cord-005453-4057qib7 10006 8 CMV CMV NNP cord-005453-4057qib7 10006 9 replication replication NN cord-005453-4057qib7 10006 10 in in IN cord-005453-4057qib7 10006 11 OS OS NNP cord-005453-4057qib7 10006 12 we -PRON- PRP cord-005453-4057qib7 10006 13 perform perform VBP cord-005453-4057qib7 10006 14 a a DT cord-005453-4057qib7 10006 15 unicentric unicentric JJ cord-005453-4057qib7 10006 16 , , , cord-005453-4057qib7 10006 17 retrospective retrospective JJ cord-005453-4057qib7 10006 18 study study NN cord-005453-4057qib7 10006 19 on on IN cord-005453-4057qib7 10006 20 117 117 CD cord-005453-4057qib7 10006 21 consecutive consecutive JJ cord-005453-4057qib7 10006 22 first first JJ cord-005453-4057qib7 10006 23 allo allo NN cord-005453-4057qib7 10006 24 - - HYPH cord-005453-4057qib7 10006 25 HSCT HSCT NNP cord-005453-4057qib7 10006 26 patients patient NNS cord-005453-4057qib7 10006 27 transplanted transplant VBN cord-005453-4057qib7 10006 28 between between IN cord-005453-4057qib7 10006 29 Jan-2015 Jan-2015 NNP cord-005453-4057qib7 10006 30 and and CC cord-005453-4057qib7 10006 31 Oct-2018 Oct-2018 NNP cord-005453-4057qib7 10006 32 with with IN cord-005453-4057qib7 10006 33 a a DT cord-005453-4057qib7 10006 34 median median JJ cord-005453-4057qib7 10006 35 follow follow NN cord-005453-4057qib7 10006 36 - - HYPH cord-005453-4057qib7 10006 37 up up NN cord-005453-4057qib7 10006 38 of of IN cord-005453-4057qib7 10006 39 398 398 CD cord-005453-4057qib7 10006 40 days day NNS cord-005453-4057qib7 10006 41 ( ( -LRB- cord-005453-4057qib7 10006 42 5 5 CD cord-005453-4057qib7 10006 43 - - SYM cord-005453-4057qib7 10006 44 1266 1266 CD cord-005453-4057qib7 10006 45 ) ) -RRB- cord-005453-4057qib7 10006 46 . . . cord-005453-4057qib7 10007 1 All all DT cord-005453-4057qib7 10007 2 patients patient NNS cord-005453-4057qib7 10007 3 were be VBD cord-005453-4057qib7 10007 4 monitored monitor VBN cord-005453-4057qib7 10007 5 post post JJ cord-005453-4057qib7 10007 6 - - JJ cord-005453-4057qib7 10007 7 HCT hct NN cord-005453-4057qib7 10007 8 with with IN cord-005453-4057qib7 10007 9 real real JJ cord-005453-4057qib7 10007 10 time time NN cord-005453-4057qib7 10008 1 PCR PCR NNP cord-005453-4057qib7 10008 2 Cobas Cobas NNP cord-005453-4057qib7 10008 3 - - HYPH cord-005453-4057qib7 10008 4 Taqman Taqman NNP cord-005453-4057qib7 10008 5 ® ® . cord-005453-4057qib7 10008 6 /Cobas6800 /cobas6800 XX cord-005453-4057qib7 10008 7 ® ® : cord-005453-4057qib7 10008 8 ( ( -LRB- cord-005453-4057qib7 10008 9 rtPCR rtpcr XX cord-005453-4057qib7 10008 10 ) ) -RRB- cord-005453-4057qib7 10009 1 in in IN cord-005453-4057qib7 10009 2 plasma plasma NN cord-005453-4057qib7 10009 3 . . . cord-005453-4057qib7 10010 1 The the DT cord-005453-4057qib7 10010 2 cut cut NN cord-005453-4057qib7 10010 3 - - HYPH cord-005453-4057qib7 10010 4 off off NN cord-005453-4057qib7 10010 5 for for IN cord-005453-4057qib7 10010 6 inception inception NN cord-005453-4057qib7 10010 7 of of IN cord-005453-4057qib7 10010 8 PET PET NNP cord-005453-4057qib7 10010 9 was be VBD cord-005453-4057qib7 10010 10 150 150 CD cord-005453-4057qib7 10010 11 IU IU NNP cord-005453-4057qib7 10010 12 / / , cord-005453-4057qib7 10010 13 ml ml NN cord-005453-4057qib7 10010 14 . . . cord-005453-4057qib7 10011 1 CMV CMV NNP cord-005453-4057qib7 10011 2 mutations mutation NNS cord-005453-4057qib7 10012 1 ( ( -LRB- cord-005453-4057qib7 10012 2 UL54 UL54 NNP cord-005453-4057qib7 10012 3 / / SYM cord-005453-4057qib7 10012 4 UL97gene UL97gene NNP cord-005453-4057qib7 10012 5 ) ) -RRB- cord-005453-4057qib7 10012 6 , , , cord-005453-4057qib7 10012 7 were be VBD cord-005453-4057qib7 10012 8 studied study VBN cord-005453-4057qib7 10012 9 in in IN cord-005453-4057qib7 10012 10 plasma plasma NN cord-005453-4057qib7 10012 11 samples sample NNS cord-005453-4057qib7 10012 12 by by IN cord-005453-4057qib7 10012 13 Sanger Sanger NNP cord-005453-4057qib7 10012 14 sequencing sequencing NN cord-005453-4057qib7 10012 15 , , , cord-005453-4057qib7 10012 16 median median JJ cord-005453-4057qib7 10012 17 CMV CMV NNP cord-005453-4057qib7 10012 18 Viral Viral NNP cord-005453-4057qib7 10012 19 load load NN cord-005453-4057qib7 10012 20 3130 3130 CD cord-005453-4057qib7 10012 21 IU IU NNP cord-005453-4057qib7 10012 22 / / SYM cord-005453-4057qib7 10012 23 ml ml NN cord-005453-4057qib7 10012 24 ( ( -LRB- cord-005453-4057qib7 10012 25 565 565 CD cord-005453-4057qib7 10012 26 - - SYM cord-005453-4057qib7 10012 27 23900 23900 CD cord-005453-4057qib7 10012 28 ) ) -RRB- cord-005453-4057qib7 10012 29 . . . cord-005453-4057qib7 10013 1 Results result NNS cord-005453-4057qib7 10013 2 : : : cord-005453-4057qib7 10013 3 Patients patient NNS cord-005453-4057qib7 10013 4 ( ( -LRB- cord-005453-4057qib7 10013 5 117 117 CD cord-005453-4057qib7 10013 6 ) ) -RRB- cord-005453-4057qib7 10013 7 : : : cord-005453-4057qib7 10013 8 women woman NNS cord-005453-4057qib7 10013 9 / / SYM cord-005453-4057qib7 10013 10 men man NNS cord-005453-4057qib7 10013 11 ( ( -LRB- cord-005453-4057qib7 10013 12 49%/51 49%/51 CD cord-005453-4057qib7 10013 13 % % NN cord-005453-4057qib7 10013 14 ) ) -RRB- cord-005453-4057qib7 10014 1 , , , cord-005453-4057qib7 10014 2 median median JJ cord-005453-4057qib7 10014 3 age age NN cord-005453-4057qib7 10014 4 was be VBD cord-005453-4057qib7 10014 5 55 55 CD cord-005453-4057qib7 10014 6 years year NNS cord-005453-4057qib7 10015 1 ( ( -LRB- cord-005453-4057qib7 10015 2 range range NNP cord-005453-4057qib7 10015 3 18 18 CD cord-005453-4057qib7 10015 4 - - SYM cord-005453-4057qib7 10015 5 71 71 CD cord-005453-4057qib7 10015 6 ) ) -RRB- cord-005453-4057qib7 10015 7 . . . cord-005453-4057qib7 10016 1 101 101 CD cord-005453-4057qib7 10016 2 identical identical JJ cord-005453-4057qib7 10016 3 allogeneic allogeneic IN cord-005453-4057qib7 10016 4 SCTs sct NNS cord-005453-4057qib7 10016 5 ( ( -LRB- cord-005453-4057qib7 10016 6 86 86 CD cord-005453-4057qib7 10016 7 % % NN cord-005453-4057qib7 10016 8 ) ) -RRB- cord-005453-4057qib7 10016 9 , , , cord-005453-4057qib7 10016 10 16 16 CD cord-005453-4057qib7 10016 11 haploidentical haploidentical JJ cord-005453-4057qib7 10016 12 SCTs sct NNS cord-005453-4057qib7 10016 13 ( ( -LRB- cord-005453-4057qib7 10016 14 14 14 CD cord-005453-4057qib7 10016 15 % % NN cord-005453-4057qib7 10016 16 ) ) -RRB- cord-005453-4057qib7 10016 17 . . . cord-005453-4057qib7 10017 1 Donors donor NNS cord-005453-4057qib7 10017 2 were be VBD cord-005453-4057qib7 10017 3 related relate VBN cord-005453-4057qib7 10017 4 in in IN cord-005453-4057qib7 10017 5 60 60 CD cord-005453-4057qib7 10017 6 cases case NNS cord-005453-4057qib7 10017 7 ( ( -LRB- cord-005453-4057qib7 10017 8 51 51 CD cord-005453-4057qib7 10017 9 % % NN cord-005453-4057qib7 10017 10 ) ) -RRB- cord-005453-4057qib7 10017 11 and and CC cord-005453-4057qib7 10017 12 57 57 CD cord-005453-4057qib7 10017 13 ( ( -LRB- cord-005453-4057qib7 10017 14 49 49 CD cord-005453-4057qib7 10017 15 % % NN cord-005453-4057qib7 10017 16 ) ) -RRB- cord-005453-4057qib7 10017 17 unrelated unrelated JJ cord-005453-4057qib7 10017 18 . . . cord-005453-4057qib7 10018 1 Progenitors progenitor NNS cord-005453-4057qib7 10018 2 source source NN cord-005453-4057qib7 10018 3 was be VBD cord-005453-4057qib7 10018 4 98 98 CD cord-005453-4057qib7 10018 5 % % NN cord-005453-4057qib7 10018 6 peripheral peripheral JJ cord-005453-4057qib7 10018 7 blood blood NN cord-005453-4057qib7 10018 8 and and CC cord-005453-4057qib7 10018 9 2 2 CD cord-005453-4057qib7 10018 10 % % NN cord-005453-4057qib7 10018 11 bone bone NN cord-005453-4057qib7 10018 12 marrow marrow NN cord-005453-4057qib7 10018 13 . . . cord-005453-4057qib7 10019 1 CMV CMV NNP cord-005453-4057qib7 10019 2 status status NN cord-005453-4057qib7 10019 3 was be VBD cord-005453-4057qib7 10019 4 ( ( -LRB- cord-005453-4057qib7 10019 5 D+/R+ D+/R+ NNP cord-005453-4057qib7 10019 6 ) ) -RRB- cord-005453-4057qib7 10019 7 in in IN cord-005453-4057qib7 10019 8 51%(n=60 51%(n=60 CD cord-005453-4057qib7 10019 9 ) ) -RRB- cord-005453-4057qib7 10019 10 , , , cord-005453-4057qib7 10019 11 ( ( -LRB- cord-005453-4057qib7 10019 12 D+/R- D+/R- NNP cord-005453-4057qib7 10019 13 ) ) -RRB- cord-005453-4057qib7 10019 14 in in IN cord-005453-4057qib7 10019 15 9%(n=11 9%(n=11 CD cord-005453-4057qib7 10019 16 ) ) -RRB- cord-005453-4057qib7 10019 17 , , , cord-005453-4057qib7 10019 18 ( ( -LRB- cord-005453-4057qib7 10019 19 D-/R+ D-/R+ NNP cord-005453-4057qib7 10019 20 ) ) -RRB- cord-005453-4057qib7 10019 21 in in IN cord-005453-4057qib7 10019 22 26 26 CD cord-005453-4057qib7 10019 23 % % NN cord-005453-4057qib7 10019 24 ( ( -LRB- cord-005453-4057qib7 10019 25 n=31 n=31 NNP cord-005453-4057qib7 10019 26 ) ) -RRB- cord-005453-4057qib7 10019 27 and and CC cord-005453-4057qib7 10019 28 ( ( -LRB- cord-005453-4057qib7 10019 29 D-/R- D-/R- NNP cord-005453-4057qib7 10019 30 ) ) -RRB- cord-005453-4057qib7 10019 31 in in IN cord-005453-4057qib7 10019 32 11 11 CD cord-005453-4057qib7 10019 33 % % NN cord-005453-4057qib7 10019 34 ( ( -LRB- cord-005453-4057qib7 10019 35 n=13 n=13 NNP cord-005453-4057qib7 10019 36 ) ) -RRB- cord-005453-4057qib7 10019 37 , , , cord-005453-4057qib7 10019 38 unknown unknown JJ cord-005453-4057qib7 10019 39 2 2 CD cord-005453-4057qib7 10019 40 cases case NNS cord-005453-4057qib7 10019 41 . . . cord-005453-4057qib7 10020 1 Positive positive JJ cord-005453-4057qib7 10020 2 PCRs pcr NNS cord-005453-4057qib7 10020 3 were be VBD cord-005453-4057qib7 10020 4 detected detect VBN cord-005453-4057qib7 10020 5 in in IN cord-005453-4057qib7 10020 6 63 63 CD cord-005453-4057qib7 10020 7 patients patient NNS cord-005453-4057qib7 10020 8 : : : cord-005453-4057qib7 10021 1 one one CD cord-005453-4057qib7 10021 2 episode episode NN cord-005453-4057qib7 10021 3 in in IN cord-005453-4057qib7 10021 4 41 41 CD cord-005453-4057qib7 10021 5 ( ( -LRB- cord-005453-4057qib7 10021 6 65 65 CD cord-005453-4057qib7 10021 7 % % NN cord-005453-4057qib7 10021 8 ) ) -RRB- cord-005453-4057qib7 10021 9 ; ; : cord-005453-4057qib7 10021 10 2 2 CD cord-005453-4057qib7 10021 11 episodes episode NNS cord-005453-4057qib7 10021 12 in in IN cord-005453-4057qib7 10021 13 15(24 15(24 CD cord-005453-4057qib7 10021 14 % % NN cord-005453-4057qib7 10021 15 ) ) -RRB- cord-005453-4057qib7 10021 16 and and CC cord-005453-4057qib7 10021 17 3 3 CD cord-005453-4057qib7 10021 18 to to TO cord-005453-4057qib7 10021 19 5 5 CD cord-005453-4057qib7 10021 20 episodes episode NNS cord-005453-4057qib7 10021 21 in in IN cord-005453-4057qib7 10021 22 7 7 CD cord-005453-4057qib7 10021 23 patients patient NNS cord-005453-4057qib7 10021 24 ( ( -LRB- cord-005453-4057qib7 10021 25 11 11 CD cord-005453-4057qib7 10021 26 % % NN cord-005453-4057qib7 10021 27 ) ) -RRB- cord-005453-4057qib7 10021 28 . . . cord-005453-4057qib7 10022 1 Fifty fifty CD cord-005453-4057qib7 10022 2 - - HYPH cord-005453-4057qib7 10022 3 five five CD cord-005453-4057qib7 10022 4 patients patient NNS cord-005453-4057qib7 10022 5 ( ( -LRB- cord-005453-4057qib7 10022 6 87 87 CD cord-005453-4057qib7 10022 7 % % NN cord-005453-4057qib7 10022 8 ) ) -RRB- cord-005453-4057qib7 10022 9 received receive VBD cord-005453-4057qib7 10022 10 preemptive preemptive JJ cord-005453-4057qib7 10022 11 therapy therapy NN cord-005453-4057qib7 10022 12 . . . cord-005453-4057qib7 10023 1 Fourteen fourteen CD cord-005453-4057qib7 10023 2 episodes episode NNS cord-005453-4057qib7 10023 3 ( ( -LRB- cord-005453-4057qib7 10023 4 25 25 CD cord-005453-4057qib7 10023 5 % % NN cord-005453-4057qib7 10023 6 ) ) -RRB- cord-005453-4057qib7 10023 7 were be VBD cord-005453-4057qib7 10023 8 refractory/ refractory/ CD cord-005453-4057qib7 10023 9 probable probable JJ cord-005453-4057qib7 10023 10 refractory refractory JJ cord-005453-4057qib7 10023 11 CMV CMV NNP cord-005453-4057qib7 10023 12 infections infection NNS cord-005453-4057qib7 10023 13 ( ( -LRB- cord-005453-4057qib7 10023 14 according accord VBG cord-005453-4057qib7 10023 15 to to IN cord-005453-4057qib7 10023 16 the the DT cord-005453-4057qib7 10023 17 criteria criterion NNS cord-005453-4057qib7 10023 18 of of IN cord-005453-4057qib7 10023 19 Chemaly Chemaly NNP cord-005453-4057qib7 10023 20 R. R. NNP cord-005453-4057qib7 10023 21 CID CID NNP cord-005453-4057qib7 10023 22 2018 2018 CD cord-005453-4057qib7 10023 23 ) ) -RRB- cord-005453-4057qib7 10023 24 . . . cord-005453-4057qib7 10024 1 A a DT cord-005453-4057qib7 10024 2 resistant resistant JJ cord-005453-4057qib7 10024 3 mutation mutation NN cord-005453-4057qib7 10025 1 ( ( -LRB- cord-005453-4057qib7 10025 2 UL54 UL54 NNP cord-005453-4057qib7 10025 3 gene gene NN cord-005453-4057qib7 10025 4 ) ) -RRB- cord-005453-4057qib7 10025 5 was be VBD cord-005453-4057qib7 10025 6 detected detect VBN cord-005453-4057qib7 10025 7 in in IN cord-005453-4057qib7 10025 8 one one CD cord-005453-4057qib7 10025 9 patient patient NN cord-005453-4057qib7 10025 10 with with IN cord-005453-4057qib7 10025 11 refractory refractory JJ cord-005453-4057qib7 10025 12 infection infection NN cord-005453-4057qib7 10025 13 Patients patient NNS cord-005453-4057qib7 10025 14 that that WDT cord-005453-4057qib7 10025 15 developed develop VBD cord-005453-4057qib7 10025 16 CMV CMV NNP cord-005453-4057qib7 10025 17 infection infection NN cord-005453-4057qib7 10025 18 had have VBD cord-005453-4057qib7 10025 19 an an DT cord-005453-4057qib7 10025 20 inferior inferior JJ cord-005453-4057qib7 10025 21 non non JJ cord-005453-4057qib7 10025 22 - - JJ cord-005453-4057qib7 10025 23 significant significant JJ cord-005453-4057qib7 10025 24 OS os NN cord-005453-4057qib7 10025 25 at at IN cord-005453-4057qib7 10025 26 3 3 CD cord-005453-4057qib7 10025 27 years year NNS cord-005453-4057qib7 10025 28 ( ( -LRB- cord-005453-4057qib7 10025 29 61,3 61,3 CD cord-005453-4057qib7 10025 30 % % NN cord-005453-4057qib7 10025 31 VS VS NNP cord-005453-4057qib7 10025 32 76,8 76,8 CD cord-005453-4057qib7 10025 33 % % NN cord-005453-4057qib7 10025 34 Log log JJ cord-005453-4057qib7 10025 35 - - HYPH cord-005453-4057qib7 10025 36 rank rank NN cord-005453-4057qib7 10025 37 P p NN cord-005453-4057qib7 10025 38 0,346 0,346 CD cord-005453-4057qib7 10025 39 ) ) -RRB- cord-005453-4057qib7 10025 40 . . . cord-005453-4057qib7 10026 1 Those those DT cord-005453-4057qib7 10026 2 patients patient NNS cord-005453-4057qib7 10026 3 that that WDT cord-005453-4057qib7 10026 4 received receive VBD cord-005453-4057qib7 10026 5 PET pet NN cord-005453-4057qib7 10026 6 for for IN cord-005453-4057qib7 10026 7 CMV CMV NNP cord-005453-4057qib7 10026 8 had have VBD cord-005453-4057qib7 10026 9 a a DT cord-005453-4057qib7 10026 10 significant significant JJ cord-005453-4057qib7 10026 11 inferior inferior JJ cord-005453-4057qib7 10026 12 OS os NN cord-005453-4057qib7 10026 13 compared compare VBN cord-005453-4057qib7 10026 14 with with IN cord-005453-4057qib7 10026 15 those those DT cord-005453-4057qib7 10026 16 that that WDT cord-005453-4057qib7 10026 17 replicate replicate VBP cord-005453-4057qib7 10026 18 CMV CMV NNP cord-005453-4057qib7 10026 19 but but CC cord-005453-4057qib7 10026 20 did do VBD cord-005453-4057qib7 10026 21 n't not RB cord-005453-4057qib7 10026 22 receive receive VB cord-005453-4057qib7 10026 23 preemptive preemptive JJ cord-005453-4057qib7 10026 24 therapy therapy NN cord-005453-4057qib7 10026 25 ( ( -LRB- cord-005453-4057qib7 10027 1 55,6 55,6 CD cord-005453-4057qib7 10027 2 % % NN cord-005453-4057qib7 10027 3 vs vs IN cord-005453-4057qib7 10027 4 100 100 CD cord-005453-4057qib7 10027 5 % % NN cord-005453-4057qib7 10027 6 , , , cord-005453-4057qib7 10027 7 Log Log NNP cord-005453-4057qib7 10027 8 rank rank NN cord-005453-4057qib7 10027 9 p=0.04 p=0.04 NN cord-005453-4057qib7 10027 10 ) ) -RRB- cord-005453-4057qib7 10027 11 . . . cord-005453-4057qib7 10028 1 OS os NN cord-005453-4057qib7 10028 2 of of IN cord-005453-4057qib7 10028 3 patients patient NNS cord-005453-4057qib7 10028 4 that that WDT cord-005453-4057qib7 10028 5 received receive VBD cord-005453-4057qib7 10028 6 PET PET NNP cord-005453-4057qib7 10028 7 was be VBD cord-005453-4057qib7 10028 8 inferior inferior JJ cord-005453-4057qib7 10028 9 compared compare VBN cord-005453-4057qib7 10028 10 with with IN cord-005453-4057qib7 10028 11 those those DT cord-005453-4057qib7 10028 12 without without IN cord-005453-4057qib7 10028 13 PET pet NN cord-005453-4057qib7 10028 14 ( ( -LRB- cord-005453-4057qib7 10028 15 with with IN cord-005453-4057qib7 10028 16 or or CC cord-005453-4057qib7 10028 17 without without IN cord-005453-4057qib7 10028 18 infection infection NN cord-005453-4057qib7 10028 19 ) ) -RRB- cord-005453-4057qib7 10028 20 ( ( -LRB- cord-005453-4057qib7 10028 21 55,6 55,6 CD cord-005453-4057qib7 10028 22 % % NN cord-005453-4057qib7 10028 23 VS VS NNP cord-005453-4057qib7 10028 24 79,9 79,9 CD cord-005453-4057qib7 10028 25 % % NN cord-005453-4057qib7 10028 26 , , , cord-005453-4057qib7 10028 27 Logrank Logrank NNP cord-005453-4057qib7 10028 28 P P NNP cord-005453-4057qib7 10028 29 0,05 0,05 NN cord-005453-4057qib7 10028 30 ) ) -RRB- cord-005453-4057qib7 10028 31 . . . cord-005453-4057qib7 10029 1 No no DT cord-005453-4057qib7 10029 2 difference difference NN cord-005453-4057qib7 10029 3 in in IN cord-005453-4057qib7 10029 4 survival survival NN cord-005453-4057qib7 10029 5 was be VBD cord-005453-4057qib7 10029 6 found find VBN cord-005453-4057qib7 10029 7 for for IN cord-005453-4057qib7 10029 8 those those DT cord-005453-4057qib7 10029 9 patients patient NNS cord-005453-4057qib7 10029 10 treated treat VBN cord-005453-4057qib7 10029 11 pre pre JJ cord-005453-4057qib7 10029 12 - - JJ cord-005453-4057qib7 10029 13 emptively emptively RB cord-005453-4057qib7 10029 14 that that WDT cord-005453-4057qib7 10029 15 were be VBD cord-005453-4057qib7 10029 16 refractory refractory JJ cord-005453-4057qib7 10029 17 vs vs IN cord-005453-4057qib7 10029 18 no no DT cord-005453-4057qib7 10029 19 refractory refractory NN cord-005453-4057qib7 10029 20 ( ( -LRB- cord-005453-4057qib7 10029 21 53 53 CD cord-005453-4057qib7 10029 22 % % NN cord-005453-4057qib7 10029 23 vs vs IN cord-005453-4057qib7 10029 24 57,1 57,1 CD cord-005453-4057qib7 10029 25 % % NN cord-005453-4057qib7 10029 26 , , , cord-005453-4057qib7 10029 27 Log log JJ cord-005453-4057qib7 10029 28 - - HYPH cord-005453-4057qib7 10029 29 rank rank NN cord-005453-4057qib7 10029 30 P p NN cord-005453-4057qib7 10029 31 0,51 0,51 CD cord-005453-4057qib7 10029 32 ) ) -RRB- cord-005453-4057qib7 10029 33 . . . cord-005453-4057qib7 10030 1 Conclusions conclusion NNS cord-005453-4057qib7 10030 2 : : : cord-005453-4057qib7 10031 1 Patients patient NNS cord-005453-4057qib7 10031 2 that that WDT cord-005453-4057qib7 10031 3 received receive VBD cord-005453-4057qib7 10031 4 preemptive preemptive JJ cord-005453-4057qib7 10031 5 therapy therapy NN cord-005453-4057qib7 10031 6 had have VBD cord-005453-4057qib7 10031 7 a a DT cord-005453-4057qib7 10031 8 significant significant JJ cord-005453-4057qib7 10031 9 inferior inferior JJ cord-005453-4057qib7 10031 10 overall overall JJ cord-005453-4057qib7 10031 11 survival survival NN cord-005453-4057qib7 10031 12 compared compare VBN cord-005453-4057qib7 10031 13 with with IN cord-005453-4057qib7 10031 14 those those DT cord-005453-4057qib7 10031 15 that that WDT cord-005453-4057qib7 10031 16 didn´t didn´t TO cord-005453-4057qib7 10031 17 replicate replicate VB cord-005453-4057qib7 10031 18 and and CC cord-005453-4057qib7 10031 19 those those DT cord-005453-4057qib7 10031 20 that that WDT cord-005453-4057qib7 10031 21 replicate replicate VBP cord-005453-4057qib7 10031 22 CMV CMV NNP cord-005453-4057qib7 10031 23 but but CC cord-005453-4057qib7 10031 24 did do VBD cord-005453-4057qib7 10031 25 n't not RB cord-005453-4057qib7 10031 26 receive receive VB cord-005453-4057qib7 10031 27 preemptive preemptive JJ cord-005453-4057qib7 10031 28 therapy therapy NN cord-005453-4057qib7 10031 29 . . . cord-005453-4057qib7 10032 1 This this DT cord-005453-4057qib7 10032 2 reinforce reinforce VB cord-005453-4057qib7 10032 3 the the DT cord-005453-4057qib7 10032 4 relevance relevance NN cord-005453-4057qib7 10032 5 of of IN cord-005453-4057qib7 10032 6 prophylactic prophylactic JJ cord-005453-4057qib7 10032 7 strategies strategy NNS cord-005453-4057qib7 10032 8 for for IN cord-005453-4057qib7 10032 9 CMV CMV NNP cord-005453-4057qib7 10032 10 with with IN cord-005453-4057qib7 10032 11 drugs drug NNS cord-005453-4057qib7 10032 12 with with IN cord-005453-4057qib7 10032 13 good good JJ cord-005453-4057qib7 10032 14 safety safety NN cord-005453-4057qib7 10032 15 profile profile NN cord-005453-4057qib7 10032 16 like like IN cord-005453-4057qib7 10032 17 letermovir letermovir NNS cord-005453-4057qib7 10032 18 that that IN cord-005453-4057qib7 10032 19 in in IN cord-005453-4057qib7 10032 20 a a DT cord-005453-4057qib7 10032 21 randomised randomised JJ cord-005453-4057qib7 10032 22 trial trial NN cord-005453-4057qib7 10032 23 proved prove VBD cord-005453-4057qib7 10032 24 to to TO cord-005453-4057qib7 10032 25 decrease decrease VB cord-005453-4057qib7 10032 26 the the DT cord-005453-4057qib7 10032 27 need need NN cord-005453-4057qib7 10032 28 for for IN cord-005453-4057qib7 10032 29 preemptive preemptive JJ cord-005453-4057qib7 10032 30 therapy therapy NN cord-005453-4057qib7 10032 31 . . . cord-005453-4057qib7 10033 1 Disclosure disclosure NN cord-005453-4057qib7 10033 2 : : : cord-005453-4057qib7 10033 3 Rafael Rafael NNP cord-005453-4057qib7 10033 4 , , , cord-005453-4057qib7 10033 5 de de FW cord-005453-4057qib7 10033 6 la la NNP cord-005453-4057qib7 10033 7 Camara Camara NNP cord-005453-4057qib7 10033 8 : : : cord-005453-4057qib7 10033 9 has have VBZ cord-005453-4057qib7 10033 10 received receive VBN cord-005453-4057qib7 10033 11 grants grant NNS cord-005453-4057qib7 10033 12 from from IN cord-005453-4057qib7 10033 13 Astellas Astellas NNP cord-005453-4057qib7 10033 14 , , , cord-005453-4057qib7 10033 15 Gilead Gilead NNP cord-005453-4057qib7 10033 16 , , , cord-005453-4057qib7 10033 17 Janssen Janssen NNP cord-005453-4057qib7 10033 18 , , , cord-005453-4057qib7 10033 19 Merck Merck NNP cord-005453-4057qib7 10033 20 , , , cord-005453-4057qib7 10033 21 Novartis Novartis NNP cord-005453-4057qib7 10033 22 and and CC cord-005453-4057qib7 10033 23 Pfizer Pfizer NNP cord-005453-4057qib7 10033 24 Clinical Clinical NNP cord-005453-4057qib7 10033 25 evaluation evaluation NN cord-005453-4057qib7 10033 26 of of IN cord-005453-4057qib7 10033 27 stenotrophomonas stenotrophomonas NNP cord-005453-4057qib7 10033 28 maltophilia maltophilia NNP cord-005453-4057qib7 10033 29 infection infection NN cord-005453-4057qib7 10033 30 in in IN cord-005453-4057qib7 10033 31 allogeneic allogeneic JJ cord-005453-4057qib7 10033 32 hematopoietic hematopoietic JJ cord-005453-4057qib7 10033 33 stem stem NN cord-005453-4057qib7 10033 34 cell cell NN cord-005453-4057qib7 10033 35 transplant transplant NN cord-005453-4057qib7 10033 36 recipients recipient NNS cord-005453-4057qib7 10033 37 -retrospective -retrospective IN cord-005453-4057qib7 10033 38 single single JJ cord-005453-4057qib7 10033 39 - - HYPH cord-005453-4057qib7 10033 40 center center NN cord-005453-4057qib7 10033 41 data data NN cord-005453-4057qib7 10033 42 analysis analysis NN cord-005453-4057qib7 10033 43 negative negative JJ cord-005453-4057qib7 10033 44 bacillus bacillus NN cord-005453-4057qib7 10033 45 that that WDT cord-005453-4057qib7 10033 46 causes cause VBZ cord-005453-4057qib7 10033 47 severe severe JJ cord-005453-4057qib7 10033 48 infections infection NNS cord-005453-4057qib7 10033 49 associated associate VBN cord-005453-4057qib7 10033 50 with with IN cord-005453-4057qib7 10033 51 high high JJ cord-005453-4057qib7 10033 52 morbidity morbidity NN cord-005453-4057qib7 10033 53 and and CC cord-005453-4057qib7 10033 54 mortality mortality NN cord-005453-4057qib7 10033 55 in in IN cord-005453-4057qib7 10033 56 immunocompromised immunocompromised JJ cord-005453-4057qib7 10033 57 patients patient NNS cord-005453-4057qib7 10033 58 . . . cord-005453-4057qib7 10034 1 The the DT cord-005453-4057qib7 10034 2 aim aim NN cord-005453-4057qib7 10034 3 of of IN cord-005453-4057qib7 10034 4 our -PRON- PRP$ cord-005453-4057qib7 10034 5 study study NN cord-005453-4057qib7 10034 6 was be VBD cord-005453-4057qib7 10034 7 to to TO cord-005453-4057qib7 10034 8 determine determine VB cord-005453-4057qib7 10034 9 incidence incidence NN cord-005453-4057qib7 10034 10 , , , cord-005453-4057qib7 10034 11 characteristics characteristic NNS cord-005453-4057qib7 10034 12 and and CC cord-005453-4057qib7 10034 13 outcome outcome NN cord-005453-4057qib7 10034 14 of of IN cord-005453-4057qib7 10034 15 S. S. NNP cord-005453-4057qib7 10034 16 maltophilia maltophilia NNP cord-005453-4057qib7 10034 17 infection infection NN cord-005453-4057qib7 10034 18 in in IN cord-005453-4057qib7 10034 19 patients patient NNS cord-005453-4057qib7 10034 20 ( ( -LRB- cord-005453-4057qib7 10034 21 pts pts NN cord-005453-4057qib7 10034 22 ) ) -RRB- cord-005453-4057qib7 10034 23 who who WP cord-005453-4057qib7 10034 24 underwent undergo VBD cord-005453-4057qib7 10034 25 allogeneic allogeneic JJ cord-005453-4057qib7 10034 26 hematopoietic hematopoietic JJ cord-005453-4057qib7 10034 27 stem stem NN cord-005453-4057qib7 10034 28 cell cell NN cord-005453-4057qib7 10034 29 transplantations transplantation NNS cord-005453-4057qib7 10034 30 ( ( -LRB- cord-005453-4057qib7 10034 31 allo allo NN cord-005453-4057qib7 10034 32 - - HYPH cord-005453-4057qib7 10034 33 HSCT HSCT NNP cord-005453-4057qib7 10034 34 ) ) -RRB- cord-005453-4057qib7 10034 35 in in IN cord-005453-4057qib7 10034 36 Institute Institute NNP cord-005453-4057qib7 10034 37 of of IN cord-005453-4057qib7 10034 38 Hematology Hematology NNP cord-005453-4057qib7 10034 39 and and CC cord-005453-4057qib7 10034 40 Transfusion Transfusion NNP cord-005453-4057qib7 10034 41 Medicine Medicine NNP cord-005453-4057qib7 10034 42 between between IN cord-005453-4057qib7 10034 43 October October NNP cord-005453-4057qib7 10034 44 2010 2010 CD cord-005453-4057qib7 10034 45 and and CC cord-005453-4057qib7 10034 46 November November NNP cord-005453-4057qib7 10034 47 2018 2018 CD cord-005453-4057qib7 10034 48 . . . cord-005453-4057qib7 10035 1 Methods method NNS cord-005453-4057qib7 10035 2 : : : cord-005453-4057qib7 10035 3 We -PRON- PRP cord-005453-4057qib7 10035 4 retrospectively retrospectively RB cord-005453-4057qib7 10035 5 evaluated evaluate VBD cord-005453-4057qib7 10035 6 incidence incidence NN cord-005453-4057qib7 10035 7 , , , cord-005453-4057qib7 10035 8 clinical clinical JJ cord-005453-4057qib7 10035 9 features feature NNS cord-005453-4057qib7 10035 10 and and CC cord-005453-4057qib7 10035 11 outcome outcome NN cord-005453-4057qib7 10035 12 of of IN cord-005453-4057qib7 10035 13 S. S. NNP cord-005453-4057qib7 10035 14 maltophilia maltophilia NNP cord-005453-4057qib7 10035 15 infections infection NNS cord-005453-4057qib7 10035 16 in in IN cord-005453-4057qib7 10035 17 338 338 CD cord-005453-4057qib7 10035 18 consecutive consecutive JJ cord-005453-4057qib7 10035 19 patients patient NNS cord-005453-4057qib7 10035 20 with with IN cord-005453-4057qib7 10035 21 median median JJ cord-005453-4057qib7 10035 22 age-42 age-42 NN cord-005453-4057qib7 10035 23 years year NNS cord-005453-4057qib7 10035 24 ( ( -LRB- cord-005453-4057qib7 10035 25 range range VBP cord-005453-4057qib7 10035 26 19 19 CD cord-005453-4057qib7 10035 27 - - SYM cord-005453-4057qib7 10035 28 71 71 CD cord-005453-4057qib7 10035 29 ) ) -RRB- cord-005453-4057qib7 10035 30 , , , cord-005453-4057qib7 10035 31 who who WP cord-005453-4057qib7 10035 32 underwent undergo VBD cord-005453-4057qib7 10035 33 allo allo NN cord-005453-4057qib7 10035 34 - - HYPH cord-005453-4057qib7 10035 35 HSCT HSCT NNP cord-005453-4057qib7 10035 36 from from IN cord-005453-4057qib7 10035 37 unrelated unrelated JJ cord-005453-4057qib7 10035 38 donors donor NNS cord-005453-4057qib7 10035 39 -238 -238 JJ cord-005453-4057qib7 10035 40 ( ( -LRB- cord-005453-4057qib7 10035 41 70.4 70.4 CD cord-005453-4057qib7 10035 42 % % NN cord-005453-4057qib7 10035 43 ) ) -RRB- cord-005453-4057qib7 10035 44 , , , cord-005453-4057qib7 10035 45 matched match VBN cord-005453-4057qib7 10035 46 sibling sibling NN cord-005453-4057qib7 10035 47 donors donor NNS cord-005453-4057qib7 10035 48 -87 -87 NNP cord-005453-4057qib7 10035 49 ( ( -LRB- cord-005453-4057qib7 10035 50 25.7 25.7 CD cord-005453-4057qib7 10035 51 % % NN cord-005453-4057qib7 10035 52 ) ) -RRB- cord-005453-4057qib7 10035 53 and and CC cord-005453-4057qib7 10035 54 haploidentical haploidentical JJ cord-005453-4057qib7 10035 55 donors donor NNS cord-005453-4057qib7 10035 56 -13 -13 CD cord-005453-4057qib7 10035 57 ( ( -LRB- cord-005453-4057qib7 10035 58 3.9 3.9 CD cord-005453-4057qib7 10035 59 % % NN cord-005453-4057qib7 10035 60 ) ) -RRB- cord-005453-4057qib7 10035 61 in in IN cord-005453-4057qib7 10035 62 our -PRON- PRP$ cord-005453-4057qib7 10035 63 center center NN cord-005453-4057qib7 10035 64 . . . cord-005453-4057qib7 10036 1 S. S. NNP cord-005453-4057qib7 10036 2 maltophilia maltophilia NNP cord-005453-4057qib7 10036 3 was be VBD cord-005453-4057qib7 10036 4 detected detect VBN cord-005453-4057qib7 10036 5 by by IN cord-005453-4057qib7 10036 6 culture culture NN cord-005453-4057qib7 10036 7 - - HYPH cord-005453-4057qib7 10036 8 based base VBN cord-005453-4057qib7 10036 9 microbiological microbiological JJ cord-005453-4057qib7 10036 10 tests test NNS cord-005453-4057qib7 10036 11 . . . cord-005453-4057qib7 10037 1 Invasive invasive JJ cord-005453-4057qib7 10037 2 infection infection NN cord-005453-4057qib7 10037 3 was be VBD cord-005453-4057qib7 10037 4 defined define VBN cord-005453-4057qib7 10037 5 by by IN cord-005453-4057qib7 10037 6 isolation isolation NN cord-005453-4057qib7 10037 7 S. S. NNP cord-005453-4057qib7 10037 8 maltophilia maltophilia NN cord-005453-4057qib7 10037 9 from from IN cord-005453-4057qib7 10037 10 cultures culture NNS cord-005453-4057qib7 10037 11 in in IN cord-005453-4057qib7 10037 12 the the DT cord-005453-4057qib7 10037 13 presence presence NN cord-005453-4057qib7 10037 14 of of IN cord-005453-4057qib7 10037 15 both both DT cord-005453-4057qib7 10037 16 clinical clinical JJ cord-005453-4057qib7 10037 17 symptoms symptom NNS cord-005453-4057qib7 10037 18 and and CC cord-005453-4057qib7 10037 19 signs sign NNS cord-005453-4057qib7 10037 20 of of IN cord-005453-4057qib7 10037 21 infection infection NN cord-005453-4057qib7 10037 22 -blood -blood : cord-005453-4057qib7 10037 23 stream stream NN cord-005453-4057qib7 10037 24 infection infection NN cord-005453-4057qib7 10037 25 ( ( -LRB- cord-005453-4057qib7 10037 26 BSI BSI NNP cord-005453-4057qib7 10037 27 ) ) -RRB- cord-005453-4057qib7 10037 28 , , , cord-005453-4057qib7 10037 29 pneumonia pneumonia NN cord-005453-4057qib7 10037 30 with with IN cord-005453-4057qib7 10037 31 or or CC cord-005453-4057qib7 10037 32 without without IN cord-005453-4057qib7 10037 33 pulmonary pulmonary JJ cord-005453-4057qib7 10037 34 haemorrhage haemorrhage NN cord-005453-4057qib7 10037 35 . . . cord-005453-4057qib7 10038 1 The the DT cord-005453-4057qib7 10038 2 only only JJ cord-005453-4057qib7 10038 3 colonization colonization NN cord-005453-4057qib7 10038 4 status status NN cord-005453-4057qib7 10038 5 was be VBD cord-005453-4057qib7 10038 6 defined define VBN cord-005453-4057qib7 10038 7 as as IN cord-005453-4057qib7 10038 8 S. S. NNP cord-005453-4057qib7 10038 9 maltophilia maltophilia NNP cord-005453-4057qib7 10038 10 culture culture NN cord-005453-4057qib7 10038 11 - - HYPH cord-005453-4057qib7 10038 12 positive positive JJ cord-005453-4057qib7 10038 13 samples sample NNS cord-005453-4057qib7 10038 14 in in IN cord-005453-4057qib7 10038 15 the the DT cord-005453-4057qib7 10038 16 absence absence NN cord-005453-4057qib7 10038 17 of of IN cord-005453-4057qib7 10038 18 infection infection NN cord-005453-4057qib7 10038 19 symptoms symptom NNS cord-005453-4057qib7 10038 20 . . . cord-005453-4057qib7 10039 1 In in IN cord-005453-4057qib7 10039 2 vitro vitro FW cord-005453-4057qib7 10039 3 susceptibility susceptibility NN cord-005453-4057qib7 10039 4 tests test NNS cord-005453-4057qib7 10039 5 to to IN cord-005453-4057qib7 10039 6 antibiotics antibiotic NNS cord-005453-4057qib7 10039 7 were be VBD cord-005453-4057qib7 10039 8 performed perform VBN cord-005453-4057qib7 10039 9 . . . cord-005453-4057qib7 10040 1 Results result NNS cord-005453-4057qib7 10040 2 : : : cord-005453-4057qib7 10040 3 21 21 CD cord-005453-4057qib7 10040 4 pts pt NNS cord-005453-4057qib7 10040 5 ( ( -LRB- cord-005453-4057qib7 10040 6 6.2 6.2 CD cord-005453-4057qib7 10040 7 % % NN cord-005453-4057qib7 10040 8 ) ) -RRB- cord-005453-4057qib7 10040 9 with with IN cord-005453-4057qib7 10040 10 median median JJ cord-005453-4057qib7 10040 11 age-46 age-46 NN cord-005453-4057qib7 10040 12 years year NNS cord-005453-4057qib7 10040 13 ( ( -LRB- cord-005453-4057qib7 10040 14 range range VBP cord-005453-4057qib7 10040 15 19 19 CD cord-005453-4057qib7 10040 16 - - SYM cord-005453-4057qib7 10040 17 66 66 CD cord-005453-4057qib7 10040 18 ) ) -RRB- cord-005453-4057qib7 10040 19 with with IN cord-005453-4057qib7 10040 20 S.maltophilia s.maltophilia JJ cord-005453-4057qib7 10040 21 culture culture NN cord-005453-4057qib7 10040 22 positive positive JJ cord-005453-4057qib7 10040 23 samples sample NNS cord-005453-4057qib7 10040 24 were be VBD cord-005453-4057qib7 10040 25 identified identify VBN cord-005453-4057qib7 10040 26 . . . cord-005453-4057qib7 10041 1 19 19 CD cord-005453-4057qib7 10041 2 ( ( -LRB- cord-005453-4057qib7 10041 3 90.5 90.5 CD cord-005453-4057qib7 10041 4 % % NN cord-005453-4057qib7 10041 5 ) ) -RRB- cord-005453-4057qib7 10041 6 underwent undergo VBD cord-005453-4057qib7 10041 7 allo allo NN cord-005453-4057qib7 10041 8 - - HYPH cord-005453-4057qib7 10041 9 HSCT HSCT NNP cord-005453-4057qib7 10041 10 from from IN cord-005453-4057qib7 10041 11 unrelated unrelated JJ cord-005453-4057qib7 10041 12 donors donor NNS cord-005453-4057qib7 10041 13 , , , cord-005453-4057qib7 10041 14 1-from 1-from CD cord-005453-4057qib7 10041 15 matched match VBN cord-005453-4057qib7 10041 16 sibling sibling NN cord-005453-4057qib7 10041 17 donor donor NN cord-005453-4057qib7 10041 18 and and CC cord-005453-4057qib7 10041 19 1-from 1-from CD cord-005453-4057qib7 10041 20 haploidentical haploidentical JJ cord-005453-4057qib7 10041 21 donor donor NN cord-005453-4057qib7 10041 22 . . . cord-005453-4057qib7 10042 1 Among among IN cord-005453-4057qib7 10042 2 them -PRON- PRP cord-005453-4057qib7 10042 3 BSI BSI NNP cord-005453-4057qib7 10042 4 developed develop VBD cord-005453-4057qib7 10042 5 in in IN cord-005453-4057qib7 10042 6 7 7 CD cord-005453-4057qib7 10042 7 pts pts NN cord-005453-4057qib7 10042 8 ( ( -LRB- cord-005453-4057qib7 10042 9 33.3 33.3 CD cord-005453-4057qib7 10042 10 % % NN cord-005453-4057qib7 10042 11 ) ) -RRB- cord-005453-4057qib7 10042 12 , , , cord-005453-4057qib7 10042 13 pneumonia pneumonia NN cord-005453-4057qib7 10042 14 in in IN cord-005453-4057qib7 10042 15 4 4 CD cord-005453-4057qib7 10042 16 pts pt NNS cord-005453-4057qib7 10042 17 ( ( -LRB- cord-005453-4057qib7 10042 18 19 19 CD cord-005453-4057qib7 10042 19 % % NN cord-005453-4057qib7 10042 20 ) ) -RRB- cord-005453-4057qib7 10043 1 -with -with : cord-005453-4057qib7 10043 2 fulminant fulminant JJ cord-005453-4057qib7 10043 3 and and CC cord-005453-4057qib7 10043 4 fatal fatal JJ cord-005453-4057qib7 10043 5 pulmonary pulmonary JJ cord-005453-4057qib7 10043 6 hemorrhage hemorrhage NN cord-005453-4057qib7 10043 7 in in IN cord-005453-4057qib7 10043 8 3 3 CD cord-005453-4057qib7 10043 9 pts pts NN cord-005453-4057qib7 10043 10 ( ( -LRB- cord-005453-4057qib7 10043 11 14.3 14.3 CD cord-005453-4057qib7 10043 12 % % NN cord-005453-4057qib7 10043 13 ) ) -RRB- cord-005453-4057qib7 10043 14 . . . cord-005453-4057qib7 10044 1 All all DT cord-005453-4057qib7 10044 2 patients patient NNS cord-005453-4057qib7 10044 3 with with IN cord-005453-4057qib7 10044 4 pneumonia pneumonia NN cord-005453-4057qib7 10044 5 demonstrated demonstrate VBD cord-005453-4057qib7 10044 6 BSI BSI NNP cord-005453-4057qib7 10044 7 . . . cord-005453-4057qib7 10045 1 Positive positive JJ cord-005453-4057qib7 10045 2 sputum sputum NN cord-005453-4057qib7 10045 3 cultures culture NNS cord-005453-4057qib7 10045 4 were be VBD cord-005453-4057qib7 10045 5 detected detect VBN cord-005453-4057qib7 10045 6 in in IN cord-005453-4057qib7 10045 7 6 6 CD cord-005453-4057qib7 10045 8 pts pt NNS cord-005453-4057qib7 10045 9 , , , cord-005453-4057qib7 10045 10 in in IN cord-005453-4057qib7 10045 11 4 4 CD cord-005453-4057qib7 10045 12 pts pt NNS cord-005453-4057qib7 10045 13 hemoptysis hemoptysis NNP cord-005453-4057qib7 10045 14 was be VBD cord-005453-4057qib7 10045 15 observed observe VBN cord-005453-4057qib7 10045 16 . . . cord-005453-4057qib7 10046 1 The the DT cord-005453-4057qib7 10046 2 rest rest NN cord-005453-4057qib7 10046 3 of of IN cord-005453-4057qib7 10046 4 isolated isolate VBN cord-005453-4057qib7 10046 5 strains strain NNS cord-005453-4057qib7 10046 6 were be VBD cord-005453-4057qib7 10046 7 identified identify VBN cord-005453-4057qib7 10046 8 as as IN cord-005453-4057qib7 10046 9 colonization colonization NN cord-005453-4057qib7 10046 10 ( ( -LRB- cord-005453-4057qib7 10046 11 throat throat NN cord-005453-4057qib7 10046 12 -in -in SYM cord-005453-4057qib7 10046 13 3 3 CD cord-005453-4057qib7 10046 14 pts pts NN cord-005453-4057qib7 10046 15 , , , cord-005453-4057qib7 10046 16 stool stool NN cord-005453-4057qib7 10046 17 -in -in SYM cord-005453-4057qib7 10046 18 9 9 CD cord-005453-4057qib7 10046 19 pts pt NNS cord-005453-4057qib7 10046 20 ) ) -RRB- cord-005453-4057qib7 10046 21 . . . cord-005453-4057qib7 10047 1 All all DT cord-005453-4057qib7 10047 2 7 7 CD cord-005453-4057qib7 10047 3 patients patient NNS cord-005453-4057qib7 10047 4 with with IN cord-005453-4057qib7 10047 5 invasive invasive JJ cord-005453-4057qib7 10047 6 S. S. NNP cord-005453-4057qib7 10047 7 maltophilia maltophilia NN cord-005453-4057qib7 10047 8 infection infection NN cord-005453-4057qib7 10047 9 before before IN cord-005453-4057qib7 10047 10 pathogen pathogen NN cord-005453-4057qib7 10047 11 identification identification NN cord-005453-4057qib7 10047 12 demonstrated demonstrate VBD cord-005453-4057qib7 10047 13 persistent persistent JJ cord-005453-4057qib7 10047 14 fever fever NN cord-005453-4057qib7 10047 15 despite despite IN cord-005453-4057qib7 10047 16 of of IN cord-005453-4057qib7 10047 17 the the DT cord-005453-4057qib7 10047 18 use use NN cord-005453-4057qib7 10047 19 of of IN cord-005453-4057qib7 10047 20 broadspectrum broadspectrum NNP cord-005453-4057qib7 10047 21 antibiotics antibiotic NNS cord-005453-4057qib7 10047 22 ( ( -LRB- cord-005453-4057qib7 10047 23 carbapenems carbapenem NNS cord-005453-4057qib7 10047 24 , , , cord-005453-4057qib7 10047 25 glycopeptides glycopeptides NNP cord-005453-4057qib7 10047 26 , , , cord-005453-4057qib7 10047 27 aminoglycosides aminoglycoside NNS cord-005453-4057qib7 10047 28 , , , cord-005453-4057qib7 10047 29 colistin colistin NNP cord-005453-4057qib7 10047 30 ) ) -RRB- cord-005453-4057qib7 10047 31 , , , cord-005453-4057qib7 10047 32 prophylactic prophylactic JJ cord-005453-4057qib7 10047 33 antifungals antifungal NNS cord-005453-4057qib7 10047 34 and and CC cord-005453-4057qib7 10047 35 antivirals antiviral NNS cord-005453-4057qib7 10047 36 . . . cord-005453-4057qib7 10048 1 All all DT cord-005453-4057qib7 10048 2 of of IN cord-005453-4057qib7 10048 3 them -PRON- PRP cord-005453-4057qib7 10048 4 received receive VBD cord-005453-4057qib7 10048 5 fluoroquinolone fluoroquinolone NN cord-005453-4057qib7 10048 6 ( ( -LRB- cord-005453-4057qib7 10048 7 ciprofloxacin ciprofloxacin NNP cord-005453-4057qib7 10048 8 ) ) -RRB- cord-005453-4057qib7 10048 9 as as IN cord-005453-4057qib7 10048 10 a a DT cord-005453-4057qib7 10048 11 standard standard JJ cord-005453-4057qib7 10048 12 antibacterial antibacterial JJ cord-005453-4057qib7 10048 13 prophylaxis prophylaxis NN cord-005453-4057qib7 10048 14 before before IN cord-005453-4057qib7 10048 15 neutropenic neutropenic JJ cord-005453-4057qib7 10048 16 fever fever NN cord-005453-4057qib7 10048 17 occurred occur VBD cord-005453-4057qib7 10048 18 . . . cord-005453-4057qib7 10049 1 All all DT cord-005453-4057qib7 10049 2 3 3 CD cord-005453-4057qib7 10049 3 patients patient NNS cord-005453-4057qib7 10049 4 ( ( -LRB- cord-005453-4057qib7 10049 5 100 100 CD cord-005453-4057qib7 10049 6 % % NN cord-005453-4057qib7 10049 7 ) ) -RRB- cord-005453-4057qib7 10049 8 with with IN cord-005453-4057qib7 10049 9 BSI BSI NNP cord-005453-4057qib7 10049 10 , , , cord-005453-4057qib7 10049 11 pneumonia pneumonia NN cord-005453-4057qib7 10049 12 and and CC cord-005453-4057qib7 10049 13 pulmonary pulmonary JJ cord-005453-4057qib7 10049 14 hemorrhage hemorrhage NN cord-005453-4057qib7 10049 15 died die VBD cord-005453-4057qib7 10049 16 before before IN cord-005453-4057qib7 10049 17 engraftment engraftment NNP cord-005453-4057qib7 10049 18 ( ( -LRB- cord-005453-4057qib7 10049 19 ANC ANC NNP cord-005453-4057qib7 10049 20 -0.0 -0.0 HYPH cord-005453-4057qib7 10049 21 G G NNP cord-005453-4057qib7 10049 22 / / SYM cord-005453-4057qib7 10049 23 L l NN cord-005453-4057qib7 10049 24 ) ) -RRB- cord-005453-4057qib7 10049 25 -2 -2 NN cord-005453-4057qib7 10049 26 of of IN cord-005453-4057qib7 10049 27 them -PRON- PRP cord-005453-4057qib7 10049 28 during during IN cord-005453-4057qib7 10049 29 48 48 CD cord-005453-4057qib7 10049 30 - - SYM cord-005453-4057qib7 10049 31 72 72 CD cord-005453-4057qib7 10049 32 hours hour NNS cord-005453-4057qib7 10049 33 from from IN cord-005453-4057qib7 10049 34 the the DT cord-005453-4057qib7 10049 35 onset onset NN cord-005453-4057qib7 10049 36 of of IN cord-005453-4057qib7 10049 37 a a DT cord-005453-4057qib7 10049 38 positive positive JJ cord-005453-4057qib7 10049 39 blood blood NN cord-005453-4057qib7 10049 40 culture culture NN cord-005453-4057qib7 10049 41 for for IN cord-005453-4057qib7 10049 42 S. S. NNP cord-005453-4057qib7 10049 43 maltophilia maltophilia NNP cord-005453-4057qib7 10049 44 . . . cord-005453-4057qib7 10050 1 The the DT cord-005453-4057qib7 10050 2 C C NNP cord-005453-4057qib7 10050 3 - - HYPH cord-005453-4057qib7 10050 4 reactive reactive JJ cord-005453-4057qib7 10050 5 protein protein NN cord-005453-4057qib7 10050 6 ( ( -LRB- cord-005453-4057qib7 10050 7 CRP CRP NNP cord-005453-4057qib7 10050 8 ) ) -RRB- cord-005453-4057qib7 10050 9 concentration concentration NN cord-005453-4057qib7 10050 10 before before IN cord-005453-4057qib7 10050 11 identification identification NN cord-005453-4057qib7 10050 12 of of IN cord-005453-4057qib7 10050 13 S. S. NNP cord-005453-4057qib7 10050 14 maltophilia maltophilia NNP cord-005453-4057qib7 10050 15 invasive invasive JJ cord-005453-4057qib7 10050 16 infection infection NN cord-005453-4057qib7 10050 17 was be VBD cord-005453-4057qib7 10050 18 > > XX cord-005453-4057qib7 10050 19 26x-69x 26x-69x CD cord-005453-4057qib7 10050 20 upper upper JJ cord-005453-4057qib7 10050 21 normal normal JJ cord-005453-4057qib7 10050 22 limits limit NNS cord-005453-4057qib7 10050 23 ( ( -LRB- cord-005453-4057qib7 10050 24 UNL UNL NNP cord-005453-4057qib7 10050 25 ) ) -RRB- cord-005453-4057qib7 10050 26 . . . cord-005453-4057qib7 10051 1 Susceptibility susceptibility NN cord-005453-4057qib7 10051 2 to to IN cord-005453-4057qib7 10051 3 antibiotics antibiotic NNS cord-005453-4057qib7 10051 4 of of IN cord-005453-4057qib7 10051 5 isolated isolate VBN cord-005453-4057qib7 10051 6 strains strain NNS cord-005453-4057qib7 10051 7 from from IN cord-005453-4057qib7 10051 8 blood blood NN cord-005453-4057qib7 10051 9 and and CC cord-005453-4057qib7 10051 10 sputum sputum NN cord-005453-4057qib7 10051 11 was be VBD cord-005453-4057qib7 10051 12 respectively respectively RB cord-005453-4057qib7 10051 13 : : : cord-005453-4057qib7 10051 14 86 86 CD cord-005453-4057qib7 10051 15 % % NN cord-005453-4057qib7 10051 16 and and CC cord-005453-4057qib7 10051 17 100 100 CD cord-005453-4057qib7 10051 18 % % NN cord-005453-4057qib7 10051 19 for for IN cord-005453-4057qib7 10051 20 ceftazidime ceftazidime NN cord-005453-4057qib7 10051 21 , , , cord-005453-4057qib7 10051 22 100 100 CD cord-005453-4057qib7 10051 23 % % NN cord-005453-4057qib7 10051 24 and and CC cord-005453-4057qib7 10051 25 100 100 CD cord-005453-4057qib7 10051 26 % % NN cord-005453-4057qib7 10051 27 for for IN cord-005453-4057qib7 10051 28 trimethoprim trimethoprim NNP cord-005453-4057qib7 10051 29 - - HYPH cord-005453-4057qib7 10051 30 sulfamethoxazole sulfamethoxazole NNP cord-005453-4057qib7 10051 31 , , , cord-005453-4057qib7 10051 32 64 64 CD cord-005453-4057qib7 10051 33 % % NN cord-005453-4057qib7 10051 34 and and CC cord-005453-4057qib7 10051 35 50 50 CD cord-005453-4057qib7 10051 36 % % NN cord-005453-4057qib7 10051 37 for for IN cord-005453-4057qib7 10051 38 levofloxacin levofloxacin NNS cord-005453-4057qib7 10051 39 ; ; : cord-005453-4057qib7 10051 40 while while IN cord-005453-4057qib7 10051 41 56 56 CD cord-005453-4057qib7 10051 42 % % NN cord-005453-4057qib7 10051 43 and and CC cord-005453-4057qib7 10051 44 50 50 CD cord-005453-4057qib7 10051 45 % % NN cord-005453-4057qib7 10051 46 strains strain NNS cord-005453-4057qib7 10051 47 were be VBD cord-005453-4057qib7 10051 48 resistant resistant JJ cord-005453-4057qib7 10051 49 to to IN cord-005453-4057qib7 10051 50 ciprofloxacin ciprofloxacin NN cord-005453-4057qib7 10051 51 . . . cord-005453-4057qib7 10052 1 1-year 1-year CD cord-005453-4057qib7 10052 2 overal overal JJ cord-005453-4057qib7 10052 3 survival survival NN cord-005453-4057qib7 10052 4 ( ( -LRB- cord-005453-4057qib7 10052 5 OS OS NNP cord-005453-4057qib7 10052 6 ) ) -RRB- cord-005453-4057qib7 10052 7 and and CC cord-005453-4057qib7 10052 8 2-y 2-y CD cord-005453-4057qib7 10052 9 OS os NN cord-005453-4057qib7 10052 10 for for IN cord-005453-4057qib7 10052 11 this this DT cord-005453-4057qib7 10052 12 group group NN cord-005453-4057qib7 10052 13 was be VBD cord-005453-4057qib7 10052 14 52.4 52.4 CD cord-005453-4057qib7 10052 15 % % NN cord-005453-4057qib7 10052 16 and and CC cord-005453-4057qib7 10052 17 47.6 47.6 CD cord-005453-4057qib7 10052 18 % % NN cord-005453-4057qib7 10052 19 respectively respectively RB cord-005453-4057qib7 10052 20 compared compare VBN cord-005453-4057qib7 10052 21 with with IN cord-005453-4057qib7 10052 22 77.2 77.2 CD cord-005453-4057qib7 10052 23 % % NN cord-005453-4057qib7 10052 24 and and CC cord-005453-4057qib7 10052 25 68.3 68.3 CD cord-005453-4057qib7 10052 26 % % NN cord-005453-4057qib7 10052 27 for for IN cord-005453-4057qib7 10052 28 group group NN cord-005453-4057qib7 10052 29 without without IN cord-005453-4057qib7 10052 30 S. S. NNP cord-005453-4057qib7 10052 31 maltophilia maltophilia NNP cord-005453-4057qib7 10052 32 infection infection NN cord-005453-4057qib7 10052 33 . . . cord-005453-4057qib7 10053 1 Conclusions conclusion NNS cord-005453-4057qib7 10053 2 : : : cord-005453-4057qib7 10054 1 S. S. NNP cord-005453-4057qib7 10054 2 maltophilia maltophilia VBD cord-005453-4057qib7 10054 3 invasive invasive JJ cord-005453-4057qib7 10054 4 infections infection NNS cord-005453-4057qib7 10054 5 are be VBP cord-005453-4057qib7 10054 6 associated associate VBN cord-005453-4057qib7 10054 7 with with IN cord-005453-4057qib7 10054 8 high high JJ cord-005453-4057qib7 10054 9 morbidity morbidity NN cord-005453-4057qib7 10054 10 and and CC cord-005453-4057qib7 10054 11 mortality mortality NN cord-005453-4057qib7 10054 12 in in IN cord-005453-4057qib7 10054 13 allo allo NN cord-005453-4057qib7 10054 14 - - HYPH cord-005453-4057qib7 10054 15 HSCT HSCT NNP cord-005453-4057qib7 10054 16 recipients recipient NNS cord-005453-4057qib7 10054 17 especially especially RB cord-005453-4057qib7 10054 18 in in IN cord-005453-4057qib7 10054 19 the the DT cord-005453-4057qib7 10054 20 period period NN cord-005453-4057qib7 10054 21 from from IN cord-005453-4057qib7 10054 22 conditioning conditioning NN cord-005453-4057qib7 10054 23 therapy therapy NN cord-005453-4057qib7 10054 24 to to IN cord-005453-4057qib7 10054 25 engraftment engraftment NNP cord-005453-4057qib7 10054 26 . . . cord-005453-4057qib7 10055 1 An an DT cord-005453-4057qib7 10055 2 exposure exposure NN cord-005453-4057qib7 10055 3 to to IN cord-005453-4057qib7 10055 4 broad broad JJ cord-005453-4057qib7 10055 5 - - HYPH cord-005453-4057qib7 10055 6 spectrum spectrum NN cord-005453-4057qib7 10055 7 antibiotics antibiotic NNS cord-005453-4057qib7 10055 8 in in IN cord-005453-4057qib7 10055 9 the the DT cord-005453-4057qib7 10055 10 treatment treatment NN cord-005453-4057qib7 10055 11 of of IN cord-005453-4057qib7 10055 12 neutropenic neutropenic JJ cord-005453-4057qib7 10055 13 fever fever NN cord-005453-4057qib7 10055 14 or or CC cord-005453-4057qib7 10055 15 confirmed confirm VBD cord-005453-4057qib7 10055 16 bacteremia bacteremia NN cord-005453-4057qib7 10055 17 of of IN cord-005453-4057qib7 10055 18 other other JJ cord-005453-4057qib7 10055 19 etiology etiology NN cord-005453-4057qib7 10055 20 is be VBZ cord-005453-4057qib7 10055 21 one one CD cord-005453-4057qib7 10055 22 of of IN cord-005453-4057qib7 10055 23 risk risk NN cord-005453-4057qib7 10055 24 factors factor NNS cord-005453-4057qib7 10055 25 of of IN cord-005453-4057qib7 10055 26 breakthrough breakthrough NN cord-005453-4057qib7 10055 27 S. S. NNP cord-005453-4057qib7 10055 28 maltophilia maltophilia NNP cord-005453-4057qib7 10055 29 infections infection NNS cord-005453-4057qib7 10055 30 . . . cord-005453-4057qib7 10056 1 Empiric empiric NN cord-005453-4057qib7 10056 2 therapy therapy NN cord-005453-4057qib7 10056 3 against against IN cord-005453-4057qib7 10056 4 S. S. NNP cord-005453-4057qib7 10056 5 maltophilia maltophilia NNP cord-005453-4057qib7 10056 6 in in IN cord-005453-4057qib7 10056 7 selected select VBN cord-005453-4057qib7 10056 8 patients patient NNS cord-005453-4057qib7 10056 9 in in IN cord-005453-4057qib7 10056 10 risk risk NN cord-005453-4057qib7 10056 11 of of IN cord-005453-4057qib7 10056 12 such such JJ cord-005453-4057qib7 10056 13 infection infection NN cord-005453-4057qib7 10056 14 before before IN cord-005453-4057qib7 10056 15 pathogen pathogen NN cord-005453-4057qib7 10056 16 identification identification NN cord-005453-4057qib7 10056 17 may may MD cord-005453-4057qib7 10056 18 be be VB cord-005453-4057qib7 10056 19 lifesaving lifesave VBG cord-005453-4057qib7 10056 20 procedure procedure NN cord-005453-4057qib7 10056 21 . . . cord-005453-4057qib7 10057 1 Disclosure disclosure NN cord-005453-4057qib7 10057 2 : : : cord-005453-4057qib7 10057 3 Nothing nothing NN cord-005453-4057qib7 10057 4 to to TO cord-005453-4057qib7 10057 5 declare declare VB cord-005453-4057qib7 10057 6 . . . cord-005453-4057qib7 10058 1 Role role NN cord-005453-4057qib7 10058 2 of of IN cord-005453-4057qib7 10058 3 CMV CMV NNP cord-005453-4057qib7 10058 4 reactivation reactivation NN cord-005453-4057qib7 10058 5 following follow VBG cord-005453-4057qib7 10058 6 allogeneic allogeneic IN cord-005453-4057qib7 10058 7 stem stem NN cord-005453-4057qib7 10058 8 cell cell NN cord-005453-4057qib7 10058 9 transplantation transplantation NN cord-005453-4057qib7 10058 10 in in IN cord-005453-4057qib7 10058 11 preventing prevent VBG cord-005453-4057qib7 10058 12 relapses relapse NNS cord-005453-4057qib7 10058 13 in in IN cord-005453-4057qib7 10058 14 patients patient NNS cord-005453-4057qib7 10058 15 with with IN cord-005453-4057qib7 10058 16 acute acute JJ cord-005453-4057qib7 10058 17 myeloid myeloid NN cord-005453-4057qib7 10058 18 leukemia leukemia NN cord-005453-4057qib7 10058 19 Background background NN cord-005453-4057qib7 10058 20 : : : cord-005453-4057qib7 10059 1 Cytomegalovirus(CMV Cytomegalovirus(CMV NNP cord-005453-4057qib7 10059 2 ) ) -RRB- cord-005453-4057qib7 10059 3 reactivation reactivation NN cord-005453-4057qib7 10059 4 is be VBZ cord-005453-4057qib7 10059 5 common common JJ cord-005453-4057qib7 10059 6 in in IN cord-005453-4057qib7 10059 7 patients patient NNS cord-005453-4057qib7 10059 8 undergoing undergo VBG cord-005453-4057qib7 10059 9 Allogeneic Allogeneic NNP cord-005453-4057qib7 10059 10 Stem Stem NNP cord-005453-4057qib7 10059 11 Cell Cell NNP cord-005453-4057qib7 10059 12 transplantation transplantation NN cord-005453-4057qib7 10059 13 . . . cord-005453-4057qib7 10060 1 It -PRON- PRP cord-005453-4057qib7 10060 2 has have VBZ cord-005453-4057qib7 10060 3 been be VBN cord-005453-4057qib7 10060 4 shown show VBN cord-005453-4057qib7 10060 5 recently recently RB cord-005453-4057qib7 10060 6 that that IN cord-005453-4057qib7 10060 7 CMV CMV NNP cord-005453-4057qib7 10060 8 reactivation reactivation NN cord-005453-4057qib7 10060 9 is be VBZ cord-005453-4057qib7 10060 10 associated associate VBN cord-005453-4057qib7 10060 11 with with IN cord-005453-4057qib7 10060 12 reduced reduced JJ cord-005453-4057qib7 10060 13 risks risk NNS cord-005453-4057qib7 10060 14 of of IN cord-005453-4057qib7 10060 15 relapse relapse NN cord-005453-4057qib7 10060 16 in in IN cord-005453-4057qib7 10060 17 patients patient NNS cord-005453-4057qib7 10060 18 undergoing undergo VBG cord-005453-4057qib7 10060 19 Allogeneic Allogeneic NNP cord-005453-4057qib7 10060 20 Stem Stem NNP cord-005453-4057qib7 10060 21 Cell Cell NNP cord-005453-4057qib7 10060 22 Transplantation transplantation NN cord-005453-4057qib7 10060 23 for for IN cord-005453-4057qib7 10060 24 AML AML NNP cord-005453-4057qib7 10060 25 . . . cord-005453-4057qib7 10061 1 However however RB cord-005453-4057qib7 10061 2 the the DT cord-005453-4057qib7 10061 3 analysis analysis NN cord-005453-4057qib7 10061 4 of of IN cord-005453-4057qib7 10061 5 CIBMTR CIBMTR NNP cord-005453-4057qib7 10061 6 data datum NNS cord-005453-4057qib7 10061 7 did do VBD cord-005453-4057qib7 10061 8 not not RB cord-005453-4057qib7 10061 9 show show VB cord-005453-4057qib7 10061 10 any any DT cord-005453-4057qib7 10061 11 effect effect NN cord-005453-4057qib7 10061 12 of of IN cord-005453-4057qib7 10061 13 CMV CMV NNP cord-005453-4057qib7 10061 14 reactivation reactivation NN cord-005453-4057qib7 10061 15 on on IN cord-005453-4057qib7 10061 16 relapse relapse NN cord-005453-4057qib7 10061 17 . . . cord-005453-4057qib7 10062 1 With with IN cord-005453-4057qib7 10062 2 this this DT cord-005453-4057qib7 10062 3 background background NN cord-005453-4057qib7 10062 4 we -PRON- PRP cord-005453-4057qib7 10062 5 conducted conduct VBD cord-005453-4057qib7 10062 6 an an DT cord-005453-4057qib7 10062 7 analysis analysis NN cord-005453-4057qib7 10062 8 of of IN cord-005453-4057qib7 10062 9 patients patient NNS cord-005453-4057qib7 10062 10 suffering suffer VBG cord-005453-4057qib7 10062 11 from from IN cord-005453-4057qib7 10062 12 AML AML NNP cord-005453-4057qib7 10062 13 who who WP cord-005453-4057qib7 10062 14 are be VBP cord-005453-4057qib7 10062 15 undergoing undergo VBG cord-005453-4057qib7 10062 16 Allo Allo NNP cord-005453-4057qib7 10062 17 - - HYPH cord-005453-4057qib7 10062 18 SCT SCT NNP cord-005453-4057qib7 10062 19 for for IN cord-005453-4057qib7 10062 20 their -PRON- PRP$ cord-005453-4057qib7 10062 21 long long JJ cord-005453-4057qib7 10062 22 term term NN cord-005453-4057qib7 10062 23 disease disease NN cord-005453-4057qib7 10062 24 free free JJ cord-005453-4057qib7 10062 25 survival survival NN cord-005453-4057qib7 10062 26 with with IN cord-005453-4057qib7 10062 27 respect respect NN cord-005453-4057qib7 10062 28 to to IN cord-005453-4057qib7 10062 29 CMV CMV NNP cord-005453-4057qib7 10062 30 reactivation reactivation NN cord-005453-4057qib7 10062 31 . . . cord-005453-4057qib7 10063 1 Methods method NNS cord-005453-4057qib7 10063 2 : : : cord-005453-4057qib7 10063 3 After after IN cord-005453-4057qib7 10063 4 obtaining obtain VBG cord-005453-4057qib7 10063 5 permission permission NN cord-005453-4057qib7 10063 6 from from IN cord-005453-4057qib7 10063 7 hospital hospital NN cord-005453-4057qib7 10063 8 medical medical JJ cord-005453-4057qib7 10063 9 records records NNPS cord-005453-4057qib7 10063 10 committee committee NN cord-005453-4057qib7 10063 11 , , , cord-005453-4057qib7 10063 12 we -PRON- PRP cord-005453-4057qib7 10063 13 retrospectively retrospectively RB cord-005453-4057qib7 10063 14 analysed analyse VBD cord-005453-4057qib7 10063 15 data datum NNS cord-005453-4057qib7 10063 16 from from IN cord-005453-4057qib7 10063 17 electronic electronic JJ cord-005453-4057qib7 10063 18 medical medical JJ cord-005453-4057qib7 10063 19 records record NNS cord-005453-4057qib7 10063 20 of of IN cord-005453-4057qib7 10063 21 patients patient NNS cord-005453-4057qib7 10063 22 undergoing undergo VBG cord-005453-4057qib7 10063 23 Allo Allo NNP cord-005453-4057qib7 10063 24 - - HYPH cord-005453-4057qib7 10063 25 SCT SCT NNP cord-005453-4057qib7 10063 26 for for IN cord-005453-4057qib7 10063 27 AML AML NNP cord-005453-4057qib7 10063 28 at at IN cord-005453-4057qib7 10063 29 our -PRON- PRP$ cord-005453-4057qib7 10063 30 center center NN cord-005453-4057qib7 10063 31 between between IN cord-005453-4057qib7 10063 32 January January NNP cord-005453-4057qib7 10063 33 2013 2013 CD cord-005453-4057qib7 10063 34 to to IN cord-005453-4057qib7 10063 35 August August NNP cord-005453-4057qib7 10063 36 2018 2018 CD cord-005453-4057qib7 10063 37 . . . cord-005453-4057qib7 10064 1 Patients patient NNS cord-005453-4057qib7 10064 2 who who WP cord-005453-4057qib7 10064 3 underwent undergo VBD cord-005453-4057qib7 10064 4 Matched matched JJ cord-005453-4057qib7 10064 5 sibling sibling NN cord-005453-4057qib7 10064 6 , , , cord-005453-4057qib7 10064 7 Matched match VBN cord-005453-4057qib7 10064 8 unrelated unrelated JJ cord-005453-4057qib7 10064 9 and and CC cord-005453-4057qib7 10064 10 partially partially RB cord-005453-4057qib7 10064 11 matched match VBN cord-005453-4057qib7 10064 12 Allo Allo NNP cord-005453-4057qib7 10064 13 SCT SCT NNP cord-005453-4057qib7 10064 14 were be VBD cord-005453-4057qib7 10064 15 included include VBN cord-005453-4057qib7 10064 16 . . . cord-005453-4057qib7 10065 1 All all DT cord-005453-4057qib7 10065 2 patients patient NNS cord-005453-4057qib7 10065 3 underwent undergo VBD cord-005453-4057qib7 10065 4 CMV CMV NNP cord-005453-4057qib7 10065 5 monitoring monitor VBG cord-005453-4057qib7 10065 6 with with IN cord-005453-4057qib7 10065 7 weekly weekly JJ cord-005453-4057qib7 10065 8 PCR PCR NNP cord-005453-4057qib7 10065 9 starting start VBG cord-005453-4057qib7 10065 10 from from IN cord-005453-4057qib7 10065 11 the the DT cord-005453-4057qib7 10065 12 time time NN cord-005453-4057qib7 10065 13 of of IN cord-005453-4057qib7 10065 14 engraftment engraftment NN cord-005453-4057qib7 10065 15 till till IN cord-005453-4057qib7 10065 16 D+100 D+100 NNS cord-005453-4057qib7 10065 17 following follow VBG cord-005453-4057qib7 10065 18 Allo Allo NNP cord-005453-4057qib7 10065 19 SCT SCT NNP cord-005453-4057qib7 10065 20 . . . cord-005453-4057qib7 10066 1 Value value NN cord-005453-4057qib7 10066 2 of of IN cord-005453-4057qib7 10066 3 ≥ ≥ CD cord-005453-4057qib7 10066 4 1000 1000 CD cord-005453-4057qib7 10066 5 copies copy NNS cord-005453-4057qib7 10066 6 / / SYM cord-005453-4057qib7 10066 7 mcl mcl NNP cord-005453-4057qib7 10066 8 was be VBD cord-005453-4057qib7 10066 9 considered consider VBN cord-005453-4057qib7 10066 10 as as IN cord-005453-4057qib7 10066 11 cut cut VBN cord-005453-4057qib7 10066 12 off off RP cord-005453-4057qib7 10066 13 for for IN cord-005453-4057qib7 10066 14 initiation initiation NN cord-005453-4057qib7 10066 15 of of IN cord-005453-4057qib7 10066 16 treatment treatment NN cord-005453-4057qib7 10066 17 in in IN cord-005453-4057qib7 10066 18 matched match VBN cord-005453-4057qib7 10066 19 sibling sibling NN cord-005453-4057qib7 10066 20 donor donor NN cord-005453-4057qib7 10066 21 transplant transplant NN cord-005453-4057qib7 10066 22 but but CC cord-005453-4057qib7 10066 23 in in IN cord-005453-4057qib7 10066 24 unrelated unrelated JJ cord-005453-4057qib7 10066 25 donor donor NN cord-005453-4057qib7 10066 26 or or CC cord-005453-4057qib7 10066 27 partially partially RB cord-005453-4057qib7 10066 28 matched match VBN cord-005453-4057qib7 10066 29 donor donor NN cord-005453-4057qib7 10066 30 transplants transplant NNS cord-005453-4057qib7 10066 31 , , , cord-005453-4057qib7 10066 32 ≥ ≥ CD cord-005453-4057qib7 10066 33 500 500 CD cord-005453-4057qib7 10066 34 copies copy NNS cord-005453-4057qib7 10066 35 / / SYM cord-005453-4057qib7 10066 36 mcl mcl NNP cord-005453-4057qib7 10066 37 was be VBD cord-005453-4057qib7 10066 38 used use VBN cord-005453-4057qib7 10066 39 as as IN cord-005453-4057qib7 10066 40 cut cut VBN cord-005453-4057qib7 10066 41 off off RP cord-005453-4057qib7 10066 42 for for IN cord-005453-4057qib7 10066 43 initiation initiation NN cord-005453-4057qib7 10066 44 of of IN cord-005453-4057qib7 10066 45 pre pre JJ cord-005453-4057qib7 10066 46 emptive emptive JJ cord-005453-4057qib7 10066 47 therapy therapy NN cord-005453-4057qib7 10066 48 . . . cord-005453-4057qib7 10067 1 Results result NNS cord-005453-4057qib7 10067 2 : : : cord-005453-4057qib7 10067 3 Total total NN cord-005453-4057qib7 10067 4 of of IN cord-005453-4057qib7 10067 5 96 96 CD cord-005453-4057qib7 10067 6 patients patient NNS cord-005453-4057qib7 10067 7 were be VBD cord-005453-4057qib7 10067 8 included include VBN cord-005453-4057qib7 10067 9 in in IN cord-005453-4057qib7 10067 10 study study NN cord-005453-4057qib7 10067 11 . . . cord-005453-4057qib7 10068 1 Median median JJ cord-005453-4057qib7 10068 2 age age NN cord-005453-4057qib7 10068 3 was be VBD cord-005453-4057qib7 10068 4 28.01 28.01 CD cord-005453-4057qib7 10068 5 ± ± NNP cord-005453-4057qib7 10068 6 17.09years 17.09years CD cord-005453-4057qib7 10068 7 ( ( -LRB- cord-005453-4057qib7 10068 8 2 2 CD cord-005453-4057qib7 10068 9 - - HYPH cord-005453-4057qib7 10068 10 69yrs 69yrs NN cord-005453-4057qib7 10068 11 ) ) -RRB- cord-005453-4057qib7 10068 12 . . . cord-005453-4057qib7 10069 1 60(62.5 60(62.5 CD cord-005453-4057qib7 10069 2 % % NN cord-005453-4057qib7 10069 3 ) ) -RRB- cord-005453-4057qib7 10069 4 , , . cord-005453-4057qib7 10070 1 30(31.3 30(31.3 CD cord-005453-4057qib7 10070 2 % % NN cord-005453-4057qib7 10070 3 ) ) -RRB- cord-005453-4057qib7 10070 4 and and CC cord-005453-4057qib7 10070 5 6(6.3 6(6.3 CD cord-005453-4057qib7 10070 6 % % NN cord-005453-4057qib7 10070 7 ) ) -RRB- cord-005453-4057qib7 10070 8 patients patient NNS cord-005453-4057qib7 10070 9 underwent undergo VBD cord-005453-4057qib7 10070 10 Matched Matched NNP cord-005453-4057qib7 10070 11 Sibling Sibling NNP cord-005453-4057qib7 10070 12 , , , cord-005453-4057qib7 10070 13 Haplo Haplo NNP cord-005453-4057qib7 10070 14 ( ( -LRB- cord-005453-4057qib7 10070 15 Partially partially RB cord-005453-4057qib7 10070 16 matched match VBN cord-005453-4057qib7 10070 17 ) ) -RRB- cord-005453-4057qib7 10070 18 and and CC cord-005453-4057qib7 10070 19 MUD mud NN cord-005453-4057qib7 10070 20 transplantation transplantation NN cord-005453-4057qib7 10070 21 respectively respectively RB cord-005453-4057qib7 10070 22 . . . cord-005453-4057qib7 10071 1 Median median JJ cord-005453-4057qib7 10071 2 follow follow VBP cord-005453-4057qib7 10071 3 up up RP cord-005453-4057qib7 10071 4 was be VBD cord-005453-4057qib7 10071 5 15 15 CD cord-005453-4057qib7 10071 6 months(1 months(1 NN cord-005453-4057qib7 10071 7 - - HYPH cord-005453-4057qib7 10071 8 73months 73months CD cord-005453-4057qib7 10071 9 ) ) -RRB- cord-005453-4057qib7 10071 10 . . . cord-005453-4057qib7 10072 1 ( ( -LRB- cord-005453-4057qib7 10072 2 Table table NN cord-005453-4057qib7 10072 3 1 1 CD cord-005453-4057qib7 10072 4 ) ) -RRB- cord-005453-4057qib7 10073 1 Acute acute JJ cord-005453-4057qib7 10073 2 GVHD GVHD NNP cord-005453-4057qib7 10074 1 ( ( -LRB- cord-005453-4057qib7 10074 2 Grade2 Grade2 NNP cord-005453-4057qib7 10074 3 - - HYPH cord-005453-4057qib7 10074 4 4 4 CD cord-005453-4057qib7 10074 5 ) ) -RRB- cord-005453-4057qib7 10074 6 was be VBD cord-005453-4057qib7 10074 7 observed observe VBN cord-005453-4057qib7 10074 8 in in IN cord-005453-4057qib7 10074 9 50(52.1 50(52.1 CD cord-005453-4057qib7 10074 10 % % NN cord-005453-4057qib7 10074 11 ) ) -RRB- cord-005453-4057qib7 10074 12 of of IN cord-005453-4057qib7 10074 13 patients patient NNS cord-005453-4057qib7 10074 14 . . . cord-005453-4057qib7 10075 1 CMV CMV NNP cord-005453-4057qib7 10075 2 reactivation reactivation NN cord-005453-4057qib7 10075 3 occurred occur VBD cord-005453-4057qib7 10075 4 in in IN cord-005453-4057qib7 10075 5 70(72.9 70(72.9 CD cord-005453-4057qib7 10075 6 % % NN cord-005453-4057qib7 10075 7 ) ) -RRB- cord-005453-4057qib7 10075 8 of of IN cord-005453-4057qib7 10075 9 patients patient NNS cord-005453-4057qib7 10075 10 . . . cord-005453-4057qib7 10076 1 Overall overall JJ cord-005453-4057qib7 10076 2 survival survival NN cord-005453-4057qib7 10076 3 at at IN cord-005453-4057qib7 10076 4 last last JJ cord-005453-4057qib7 10076 5 follow follow NN cord-005453-4057qib7 10076 6 up up RP cord-005453-4057qib7 10076 7 was be VBD cord-005453-4057qib7 10076 8 63.5 63.5 CD cord-005453-4057qib7 10076 9 % % NN cord-005453-4057qib7 10076 10 ( ( -LRB- cord-005453-4057qib7 10076 11 61/ 61/ CD cord-005453-4057qib7 10076 12 96patients 96patients CD cord-005453-4057qib7 10076 13 ) ) -RRB- cord-005453-4057qib7 10076 14 . . . cord-005453-4057qib7 10077 1 17(17.7 17(17.7 CD cord-005453-4057qib7 10077 2 % % NN cord-005453-4057qib7 10077 3 ) ) -RRB- cord-005453-4057qib7 10077 4 patients patient NNS cord-005453-4057qib7 10077 5 relapsed relapse VBD cord-005453-4057qib7 10077 6 during during IN cord-005453-4057qib7 10077 7 follow follow NN cord-005453-4057qib7 10077 8 up up RP cord-005453-4057qib7 10077 9 . . . cord-005453-4057qib7 10078 1 Relapse relapse VB cord-005453-4057qib7 10078 2 free free JJ cord-005453-4057qib7 10078 3 survival survival NN cord-005453-4057qib7 10078 4 at at IN cord-005453-4057qib7 10078 5 at at IN cord-005453-4057qib7 10078 6 last last JJ cord-005453-4057qib7 10078 7 follow follow NN cord-005453-4057qib7 10078 8 up up RP cord-005453-4057qib7 10078 9 was be VBD cord-005453-4057qib7 10078 10 61.5 61.5 CD cord-005453-4057qib7 10078 11 % % NN cord-005453-4057qib7 10078 12 . . . cord-005453-4057qib7 10079 1 64(90.1 64(90.1 CD cord-005453-4057qib7 10079 2 % % NN cord-005453-4057qib7 10079 3 ) ) -RRB- cord-005453-4057qib7 10079 4 of of IN cord-005453-4057qib7 10079 5 70 70 CD cord-005453-4057qib7 10079 6 patients patient NNS cord-005453-4057qib7 10079 7 who who WP cord-005453-4057qib7 10079 8 had have VBD cord-005453-4057qib7 10079 9 CMV CMV NNP cord-005453-4057qib7 10079 10 reactivation reactivation NN cord-005453-4057qib7 10079 11 didń didń NNP cord-005453-4057qib7 10079 12 t t NN cord-005453-4057qib7 10079 13 relapse relapse NN cord-005453-4057qib7 10079 14 , , , cord-005453-4057qib7 10079 15 whereas whereas IN cord-005453-4057qib7 10079 16 10(40 10(40 CD cord-005453-4057qib7 10079 17 % % NN cord-005453-4057qib7 10079 18 ) ) -RRB- cord-005453-4057qib7 10079 19 of of IN cord-005453-4057qib7 10079 20 25 25 CD cord-005453-4057qib7 10079 21 patients patient NNS cord-005453-4057qib7 10079 22 who who WP cord-005453-4057qib7 10079 23 didn´t didn´t TO cord-005453-4057qib7 10079 24 have have VB cord-005453-4057qib7 10079 25 CMV CMV NNP cord-005453-4057qib7 10079 26 reactivation reactivation NN cord-005453-4057qib7 10079 27 relapsed relapse VBN cord-005453-4057qib7 10079 28 which which WDT cord-005453-4057qib7 10079 29 was be VBD cord-005453-4057qib7 10079 30 statistically statistically RB cord-005453-4057qib7 10079 31 strongly strongly RB cord-005453-4057qib7 10079 32 significant significant JJ cord-005453-4057qib7 10079 33 P p NN cord-005453-4057qib7 10079 34 < < XX cord-005453-4057qib7 10079 35 0.001 0.001 CD cord-005453-4057qib7 10079 36 . . . cord-005453-4057qib7 10080 1 ( ( -LRB- cord-005453-4057qib7 10080 2 Figure figure NN cord-005453-4057qib7 10080 3 1 1 CD cord-005453-4057qib7 10080 4 ) ) -RRB- cord-005453-4057qib7 10081 1 Similar similar JJ cord-005453-4057qib7 10081 2 results result NNS cord-005453-4057qib7 10081 3 were be VBD cord-005453-4057qib7 10081 4 seen see VBN cord-005453-4057qib7 10081 5 in in IN cord-005453-4057qib7 10081 6 recently recently RB cord-005453-4057qib7 10081 7 published publish VBN cord-005453-4057qib7 10081 8 paper paper NN cord-005453-4057qib7 10081 9 from from IN cord-005453-4057qib7 10081 10 Japanese japanese JJ cord-005453-4057qib7 10081 11 Society Society NNP cord-005453-4057qib7 10081 12 For for IN cord-005453-4057qib7 10081 13 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 10081 14 Cell Cell NNP cord-005453-4057qib7 10081 15 Transplantation Transplantation NNP cord-005453-4057qib7 10081 16 ( ( -LRB- cord-005453-4057qib7 10081 17 JSHCT JSHCT NNP cord-005453-4057qib7 10081 18 ) ) -RRB- cord-005453-4057qib7 10082 1 Transplantation transplantation NN cord-005453-4057qib7 10082 2 - - HYPH cord-005453-4057qib7 10082 3 Related relate VBN cord-005453-4057qib7 10082 4 Complication complication NN cord-005453-4057qib7 10082 5 Working Working NNP cord-005453-4057qib7 10082 6 Group Group NNP cord-005453-4057qib7 10082 7 . . . cord-005453-4057qib7 10083 1 Conclusions conclusion NNS cord-005453-4057qib7 10083 2 : : : cord-005453-4057qib7 10083 3 1 1 CD cord-005453-4057qib7 10083 4 . . . cord-005453-4057qib7 10084 1 CMV CMV NNP cord-005453-4057qib7 10084 2 reactivation reactivation NN cord-005453-4057qib7 10084 3 following follow VBG cord-005453-4057qib7 10084 4 Allo Allo NNP cord-005453-4057qib7 10084 5 SCT SCT NNP cord-005453-4057qib7 10084 6 had have VBD cord-005453-4057qib7 10084 7 beneficial beneficial JJ cord-005453-4057qib7 10084 8 effect effect NN cord-005453-4057qib7 10084 9 on on IN cord-005453-4057qib7 10084 10 preventing prevent VBG cord-005453-4057qib7 10084 11 relapse relapse NN cord-005453-4057qib7 10084 12 in in IN cord-005453-4057qib7 10084 13 patients patient NNS cord-005453-4057qib7 10084 14 with with IN cord-005453-4057qib7 10084 15 AML AML NNP cord-005453-4057qib7 10084 16 . . . cord-005453-4057qib7 10085 1 2 2 LS cord-005453-4057qib7 10085 2 . . . cord-005453-4057qib7 10086 1 Probable probable JJ cord-005453-4057qib7 10086 2 immune immune JJ cord-005453-4057qib7 10086 3 activation activation NN cord-005453-4057qib7 10086 4 resulting result VBG cord-005453-4057qib7 10086 5 due due IN cord-005453-4057qib7 10086 6 to to IN cord-005453-4057qib7 10086 7 CMV CMV NNP cord-005453-4057qib7 10086 8 reactivation reactivation NN cord-005453-4057qib7 10086 9 may may MD cord-005453-4057qib7 10086 10 result result VB cord-005453-4057qib7 10086 11 in in IN cord-005453-4057qib7 10086 12 better well JJR cord-005453-4057qib7 10086 13 graft graft NN cord-005453-4057qib7 10086 14 versus versus IN cord-005453-4057qib7 10086 15 leukemia leukemia NN cord-005453-4057qib7 10086 16 effect effect NN cord-005453-4057qib7 10086 17 preventing prevent VBG cord-005453-4057qib7 10086 18 subsequent subsequent JJ cord-005453-4057qib7 10086 19 relapses relapse NNS cord-005453-4057qib7 10086 20 . . . cord-005453-4057qib7 10087 1 [ [ -LRB- cord-005453-4057qib7 10087 2 Background background NN cord-005453-4057qib7 10087 3 : : : cord-005453-4057qib7 10087 4 Human human JJ cord-005453-4057qib7 10087 5 herpesvirus herpesvirus NN cord-005453-4057qib7 10087 6 6 6 CD cord-005453-4057qib7 10087 7 ( ( -LRB- cord-005453-4057qib7 10087 8 HHV-6 HHV-6 NNP cord-005453-4057qib7 10087 9 ) ) -RRB- cord-005453-4057qib7 10087 10 causes cause VBZ cord-005453-4057qib7 10087 11 lifethreating lifethreate VBG cord-005453-4057qib7 10087 12 central central JJ cord-005453-4057qib7 10087 13 nervous nervous JJ cord-005453-4057qib7 10087 14 system system NN cord-005453-4057qib7 10087 15 disorders disorder NNS cord-005453-4057qib7 10087 16 such such JJ cord-005453-4057qib7 10087 17 as as RB cord-005453-4057qib7 10087 18 encephalitis encephalitis RB cord-005453-4057qib7 10087 19 after after IN cord-005453-4057qib7 10087 20 allogeneic allogeneic NN cord-005453-4057qib7 10087 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 10087 22 stem stem NN cord-005453-4057qib7 10087 23 cell cell NN cord-005453-4057qib7 10087 24 transplantation transplantation NN cord-005453-4057qib7 10087 25 ( ( -LRB- cord-005453-4057qib7 10087 26 HSCT HSCT NNP cord-005453-4057qib7 10087 27 ) ) -RRB- cord-005453-4057qib7 10087 28 . . . cord-005453-4057qib7 10088 1 Recent recent JJ cord-005453-4057qib7 10088 2 studies study NNS cord-005453-4057qib7 10088 3 showed show VBD cord-005453-4057qib7 10088 4 that that IN cord-005453-4057qib7 10088 5 CD134 CD134 NNP cord-005453-4057qib7 10088 6 , , , cord-005453-4057qib7 10088 7 a a DT cord-005453-4057qib7 10088 8 member member NN cord-005453-4057qib7 10088 9 of of IN cord-005453-4057qib7 10088 10 the the DT cord-005453-4057qib7 10088 11 tumor tumor NN cord-005453-4057qib7 10088 12 necrosis necrosis NN cord-005453-4057qib7 10088 13 factor factor NN cord-005453-4057qib7 10088 14 receptor receptor NN cord-005453-4057qib7 10088 15 superfamily superfamily NN cord-005453-4057qib7 10088 16 , , , cord-005453-4057qib7 10088 17 has have VBZ cord-005453-4057qib7 10088 18 been be VBN cord-005453-4057qib7 10088 19 implicated implicate VBN cord-005453-4057qib7 10088 20 as as IN cord-005453-4057qib7 10088 21 a a DT cord-005453-4057qib7 10088 22 specific specific JJ cord-005453-4057qib7 10088 23 receptor receptor NN cord-005453-4057qib7 10088 24 of of IN cord-005453-4057qib7 10088 25 HHV-6B HHV-6B NNP cord-005453-4057qib7 10088 26 , , , cord-005453-4057qib7 10088 27 and and CC cord-005453-4057qib7 10088 28 that that IN cord-005453-4057qib7 10088 29 its -PRON- PRP$ cord-005453-4057qib7 10088 30 expression expression NN cord-005453-4057qib7 10088 31 levels level NNS cord-005453-4057qib7 10088 32 in in IN cord-005453-4057qib7 10088 33 CD4-positive cd4-positive JJ cord-005453-4057qib7 10088 34 T t NN cord-005453-4057qib7 10088 35 cells cell NNS cord-005453-4057qib7 10088 36 after after IN cord-005453-4057qib7 10088 37 HSCT HSCT NNP cord-005453-4057qib7 10088 38 could could MD cord-005453-4057qib7 10088 39 be be VB cord-005453-4057qib7 10088 40 related relate VBN cord-005453-4057qib7 10088 41 to to IN cord-005453-4057qib7 10088 42 the the DT cord-005453-4057qib7 10088 43 reactivation reactivation NN cord-005453-4057qib7 10088 44 of of IN cord-005453-4057qib7 10088 45 HHV-6 HHV-6 NNP cord-005453-4057qib7 10088 46 . . . cord-005453-4057qib7 10089 1 Real real JJ cord-005453-4057qib7 10089 2 - - HYPH cord-005453-4057qib7 10089 3 time time NN cord-005453-4057qib7 10089 4 quantitative quantitative JJ cord-005453-4057qib7 10089 5 polymerase polymerase NN cord-005453-4057qib7 10089 6 chain chain NN cord-005453-4057qib7 10089 7 reaction reaction NN cord-005453-4057qib7 10089 8 analysis analysis NN cord-005453-4057qib7 10089 9 ( ( -LRB- cord-005453-4057qib7 10089 10 qPCR qPCR NNP cord-005453-4057qib7 10089 11 ) ) -RRB- cord-005453-4057qib7 10089 12 is be VBZ cord-005453-4057qib7 10089 13 the the DT cord-005453-4057qib7 10089 14 most most RBS cord-005453-4057qib7 10089 15 commonly commonly RB cord-005453-4057qib7 10089 16 used use VBN cord-005453-4057qib7 10089 17 method method NN cord-005453-4057qib7 10089 18 for for IN cord-005453-4057qib7 10089 19 detecting detect VBG cord-005453-4057qib7 10089 20 and and CC cord-005453-4057qib7 10089 21 evaluating evaluate VBG cord-005453-4057qib7 10089 22 HHV-6 HHV-6 NNP cord-005453-4057qib7 10089 23 reactivation reactivation NN cord-005453-4057qib7 10089 24 after after IN cord-005453-4057qib7 10089 25 HSCT HSCT NNP cord-005453-4057qib7 10089 26 , , , cord-005453-4057qib7 10089 27 but but CC cord-005453-4057qib7 10089 28 more more RBR cord-005453-4057qib7 10089 29 sensitive sensitive JJ cord-005453-4057qib7 10089 30 detection detection NN cord-005453-4057qib7 10089 31 method method NN cord-005453-4057qib7 10089 32 is be VBZ cord-005453-4057qib7 10089 33 required require VBN cord-005453-4057qib7 10089 34 . . . cord-005453-4057qib7 10090 1 We -PRON- PRP cord-005453-4057qib7 10090 2 recently recently RB cord-005453-4057qib7 10090 3 developed develop VBD cord-005453-4057qib7 10090 4 a a DT cord-005453-4057qib7 10090 5 new new JJ cord-005453-4057qib7 10090 6 monitoring monitoring NN cord-005453-4057qib7 10090 7 method method NN cord-005453-4057qib7 10090 8 for for IN cord-005453-4057qib7 10090 9 HHV-6 HHV-6 NNP cord-005453-4057qib7 10090 10 reactivation reactivation NN cord-005453-4057qib7 10090 11 using use VBG cord-005453-4057qib7 10090 12 digital digital JJ cord-005453-4057qib7 10090 13 PCR PCR NNP cord-005453-4057qib7 10090 14 ( ( -LRB- cord-005453-4057qib7 10090 15 dPCR dPCR NNP cord-005453-4057qib7 10090 16 ) ) -RRB- cord-005453-4057qib7 10090 17 which which WDT cord-005453-4057qib7 10090 18 provides provide VBZ cord-005453-4057qib7 10090 19 high high JJ cord-005453-4057qib7 10090 20 sensitivity sensitivity NN cord-005453-4057qib7 10090 21 of of IN cord-005453-4057qib7 10090 22 detecting detect VBG cord-005453-4057qib7 10090 23 HHV-6 HHV-6 NNP cord-005453-4057qib7 10090 24 DNA dna NN cord-005453-4057qib7 10090 25 in in IN cord-005453-4057qib7 10090 26 clinical clinical JJ cord-005453-4057qib7 10090 27 samples sample NNS cord-005453-4057qib7 10090 28 . . . cord-005453-4057qib7 10091 1 In in IN cord-005453-4057qib7 10091 2 this this DT cord-005453-4057qib7 10091 3 prospective prospective JJ cord-005453-4057qib7 10091 4 study study NN cord-005453-4057qib7 10091 5 , , , cord-005453-4057qib7 10091 6 we -PRON- PRP cord-005453-4057qib7 10091 7 evaluated evaluate VBD cord-005453-4057qib7 10091 8 the the DT cord-005453-4057qib7 10091 9 relationship relationship NN cord-005453-4057qib7 10091 10 between between IN cord-005453-4057qib7 10091 11 HHV-6 HHV-6 NNP cord-005453-4057qib7 10091 12 reactivation reactivation NN cord-005453-4057qib7 10091 13 monitored monitor VBN cord-005453-4057qib7 10091 14 by by IN cord-005453-4057qib7 10091 15 dPCR dpcr NN cord-005453-4057qib7 10091 16 and and CC cord-005453-4057qib7 10091 17 expression expression NN cord-005453-4057qib7 10091 18 of of IN cord-005453-4057qib7 10091 19 CD134 cd134 CD cord-005453-4057qib7 10091 20 on on IN cord-005453-4057qib7 10091 21 CD4 CD4 NNP cord-005453-4057qib7 10091 22 + + CC cord-005453-4057qib7 10091 23 T t NN cord-005453-4057qib7 10091 24 cells cell NNS cord-005453-4057qib7 10091 25 before before IN cord-005453-4057qib7 10091 26 and and CC cord-005453-4057qib7 10091 27 after after IN cord-005453-4057qib7 10091 28 allogeneic allogeneic NN cord-005453-4057qib7 10091 29 HSCT HSCT NNP cord-005453-4057qib7 10091 30 . . . cord-005453-4057qib7 10092 1 Methods method NNS cord-005453-4057qib7 10092 2 : : : cord-005453-4057qib7 10092 3 Thirty thirty CD cord-005453-4057qib7 10092 4 - - HYPH cord-005453-4057qib7 10092 5 four four CD cord-005453-4057qib7 10092 6 patients patient NNS cord-005453-4057qib7 10092 7 who who WP cord-005453-4057qib7 10092 8 underwent undergo VBD cord-005453-4057qib7 10092 9 allogeneic allogeneic JJ cord-005453-4057qib7 10092 10 HSCT HSCT NNP cord-005453-4057qib7 10092 11 for for IN cord-005453-4057qib7 10092 12 hematological hematological JJ cord-005453-4057qib7 10092 13 diseases disease NNS cord-005453-4057qib7 10092 14 at at IN cord-005453-4057qib7 10092 15 Keio Keio NNP cord-005453-4057qib7 10092 16 University University NNP cord-005453-4057qib7 10092 17 Hospital Hospital NNP cord-005453-4057qib7 10092 18 ( ( -LRB- cord-005453-4057qib7 10092 19 Tokyo Tokyo NNP cord-005453-4057qib7 10092 20 , , , cord-005453-4057qib7 10092 21 Japan Japan NNP cord-005453-4057qib7 10092 22 ) ) -RRB- cord-005453-4057qib7 10092 23 between between IN cord-005453-4057qib7 10092 24 January January NNP cord-005453-4057qib7 10092 25 2017 2017 CD cord-005453-4057qib7 10092 26 and and CC cord-005453-4057qib7 10092 27 March March NNP cord-005453-4057qib7 10092 28 2018 2018 CD cord-005453-4057qib7 10092 29 were be VBD cord-005453-4057qib7 10092 30 consecutively consecutively RB cord-005453-4057qib7 10092 31 enrolled enrol VBN cord-005453-4057qib7 10092 32 into into IN cord-005453-4057qib7 10092 33 this this DT cord-005453-4057qib7 10092 34 study study NN cord-005453-4057qib7 10092 35 . . . cord-005453-4057qib7 10093 1 Peripheral peripheral JJ cord-005453-4057qib7 10093 2 blood blood NN cord-005453-4057qib7 10093 3 samples sample NNS cord-005453-4057qib7 10093 4 of of IN cord-005453-4057qib7 10093 5 the the DT cord-005453-4057qib7 10093 6 patients patient NNS cord-005453-4057qib7 10093 7 were be VBD cord-005453-4057qib7 10093 8 obtained obtain VBN cord-005453-4057qib7 10093 9 before before IN cord-005453-4057qib7 10093 10 the the DT cord-005453-4057qib7 10093 11 conditioning conditioning NN cord-005453-4057qib7 10093 12 ( ( -LRB- cord-005453-4057qib7 10093 13 PRE PRE NNP cord-005453-4057qib7 10093 14 ) ) -RRB- cord-005453-4057qib7 10093 15 , , , cord-005453-4057qib7 10093 16 the the DT cord-005453-4057qib7 10093 17 day day NN cord-005453-4057qib7 10093 18 of of IN cord-005453-4057qib7 10093 19 transplant transplant NN cord-005453-4057qib7 10093 20 ( ( -LRB- cord-005453-4057qib7 10093 21 Day day NN cord-005453-4057qib7 10093 22 0 0 CD cord-005453-4057qib7 10093 23 ) ) -RRB- cord-005453-4057qib7 10093 24 , , , cord-005453-4057qib7 10093 25 and and CC cord-005453-4057qib7 10093 26 weekly weekly RB cord-005453-4057qib7 10093 27 during during IN cord-005453-4057qib7 10093 28 the the DT cord-005453-4057qib7 10093 29 first first JJ cord-005453-4057qib7 10093 30 month month NN cord-005453-4057qib7 10093 31 after after IN cord-005453-4057qib7 10093 32 transplantation transplantation NN cord-005453-4057qib7 10093 33 ( ( -LRB- cord-005453-4057qib7 10093 34 Days Days NNP cord-005453-4057qib7 10093 35 7 7 CD cord-005453-4057qib7 10093 36 , , , cord-005453-4057qib7 10093 37 14 14 CD cord-005453-4057qib7 10093 38 , , , cord-005453-4057qib7 10093 39 21 21 CD cord-005453-4057qib7 10093 40 , , , cord-005453-4057qib7 10093 41 and and CC cord-005453-4057qib7 10093 42 28 28 CD cord-005453-4057qib7 10093 43 ) ) -RRB- cord-005453-4057qib7 10093 44 . . . cord-005453-4057qib7 10094 1 HHV-6 HHV-6 NNP cord-005453-4057qib7 10094 2 viral viral JJ cord-005453-4057qib7 10094 3 load load NN cord-005453-4057qib7 10094 4 in in IN cord-005453-4057qib7 10094 5 plasma plasma NN cord-005453-4057qib7 10094 6 was be VBD cord-005453-4057qib7 10094 7 quantitatively quantitatively RB cord-005453-4057qib7 10094 8 measured measure VBN cord-005453-4057qib7 10094 9 by by IN cord-005453-4057qib7 10094 10 dPCR dPCR NNP cord-005453-4057qib7 10094 11 . . . cord-005453-4057qib7 10095 1 The the DT cord-005453-4057qib7 10095 2 primers primer NNS cord-005453-4057qib7 10095 3 and and CC cord-005453-4057qib7 10095 4 a a DT cord-005453-4057qib7 10095 5 probe probe NN cord-005453-4057qib7 10095 6 of of IN cord-005453-4057qib7 10095 7 dPCR dPCR NNP cord-005453-4057qib7 10095 8 for for IN cord-005453-4057qib7 10095 9 HHV-6B HHV-6B NNP cord-005453-4057qib7 10095 10 were be VBD cord-005453-4057qib7 10095 11 selected select VBN cord-005453-4057qib7 10095 12 from from IN cord-005453-4057qib7 10095 13 immediate immediate JJ cord-005453-4057qib7 10095 14 - - HYPH cord-005453-4057qib7 10095 15 early early JJ cord-005453-4057qib7 10095 16 1 1 CD cord-005453-4057qib7 10095 17 ( ( -LRB- cord-005453-4057qib7 10095 18 IE-1 IE-1 NNP cord-005453-4057qib7 10095 19 ) ) -RRB- cord-005453-4057qib7 10095 20 protein protein NN cord-005453-4057qib7 10095 21 transactivator transactivator NN cord-005453-4057qib7 10095 22 region region NN cord-005453-4057qib7 10095 23 ( ( -LRB- cord-005453-4057qib7 10095 24 U90 U90 NNP cord-005453-4057qib7 10095 25 ) ) -RRB- cord-005453-4057qib7 10095 26 . . . cord-005453-4057qib7 10096 1 We -PRON- PRP cord-005453-4057qib7 10096 2 evaluated evaluate VBD cord-005453-4057qib7 10096 3 the the DT cord-005453-4057qib7 10096 4 relationship relationship NN cord-005453-4057qib7 10096 5 between between IN cord-005453-4057qib7 10096 6 HHV-6 HHV-6 NNP cord-005453-4057qib7 10096 7 reactivation reactivation NN cord-005453-4057qib7 10096 8 and and CC cord-005453-4057qib7 10096 9 the the DT cord-005453-4057qib7 10096 10 serial serial JJ cord-005453-4057qib7 10096 11 expression expression NN cord-005453-4057qib7 10096 12 rates rate NNS cord-005453-4057qib7 10096 13 of of IN cord-005453-4057qib7 10096 14 CD134 cd134 CD cord-005453-4057qib7 10096 15 in in IN cord-005453-4057qib7 10096 16 CD4 CD4 NNP cord-005453-4057qib7 10096 17 + + CC cord-005453-4057qib7 10096 18 T t NN cord-005453-4057qib7 10096 19 cells cell NNS cord-005453-4057qib7 10096 20 ( ( -LRB- cord-005453-4057qib7 10096 21 CD134 CD134 NNP cord-005453-4057qib7 10096 22 / / SYM cord-005453-4057qib7 10096 23 CD4 CD4 NNP cord-005453-4057qib7 10096 24 ratio ratio NN cord-005453-4057qib7 10096 25 ) ) -RRB- cord-005453-4057qib7 10096 26 measured measure VBN cord-005453-4057qib7 10096 27 by by IN cord-005453-4057qib7 10096 28 flow flow NN cord-005453-4057qib7 10096 29 cytometry cytometry NN cord-005453-4057qib7 10096 30 before before IN cord-005453-4057qib7 10096 31 and and CC cord-005453-4057qib7 10096 32 after after IN cord-005453-4057qib7 10096 33 HSCT HSCT NNP cord-005453-4057qib7 10096 34 . . . cord-005453-4057qib7 10097 1 Results result NNS cord-005453-4057qib7 10097 2 : : : cord-005453-4057qib7 10098 1 Median median JJ cord-005453-4057qib7 10098 2 age age NN cord-005453-4057qib7 10098 3 of of IN cord-005453-4057qib7 10098 4 the the DT cord-005453-4057qib7 10098 5 patients patient NNS cord-005453-4057qib7 10098 6 was be VBD cord-005453-4057qib7 10098 7 51.5 51.5 CD cord-005453-4057qib7 10098 8 years year NNS cord-005453-4057qib7 10098 9 . . . cord-005453-4057qib7 10099 1 Onethird onethird NN cord-005453-4057qib7 10099 2 of of IN cord-005453-4057qib7 10099 3 patients patient NNS cord-005453-4057qib7 10099 4 received receive VBD cord-005453-4057qib7 10099 5 cord cord NN cord-005453-4057qib7 10099 6 blood blood NN cord-005453-4057qib7 10099 7 as as IN cord-005453-4057qib7 10099 8 a a DT cord-005453-4057qib7 10099 9 stem stem NN cord-005453-4057qib7 10099 10 cell cell NN cord-005453-4057qib7 10099 11 source source NN cord-005453-4057qib7 10099 12 . . . cord-005453-4057qib7 10100 1 HHV-6 HHV-6 NNP cord-005453-4057qib7 10100 2 reactivation reactivation NN cord-005453-4057qib7 10100 3 was be VBD cord-005453-4057qib7 10100 4 detected detect VBN cord-005453-4057qib7 10100 5 in in IN cord-005453-4057qib7 10100 6 23 23 CD cord-005453-4057qib7 10100 7 patients patient NNS cord-005453-4057qib7 10100 8 ( ( -LRB- cord-005453-4057qib7 10100 9 68 68 CD cord-005453-4057qib7 10100 10 % % NN cord-005453-4057qib7 10100 11 ) ) -RRB- cord-005453-4057qib7 10100 12 with with IN cord-005453-4057qib7 10100 13 dPCR dPCR NNP cord-005453-4057qib7 10100 14 . . . cord-005453-4057qib7 10101 1 A a DT cord-005453-4057qib7 10101 2 comparison comparison NN cord-005453-4057qib7 10101 3 of of IN cord-005453-4057qib7 10101 4 CD134 cd134 CD cord-005453-4057qib7 10101 5 / / SYM cord-005453-4057qib7 10101 6 CD4 CD4 NNP cord-005453-4057qib7 10101 7 ratio ratio NN cord-005453-4057qib7 10101 8 between between IN cord-005453-4057qib7 10101 9 the the DT cord-005453-4057qib7 10101 10 patients patient NNS cord-005453-4057qib7 10101 11 with with IN cord-005453-4057qib7 10101 12 and and CC cord-005453-4057qib7 10101 13 without without IN cord-005453-4057qib7 10101 14 HHV-6 HHV-6 NNP cord-005453-4057qib7 10101 15 reactivation reactivation NN cord-005453-4057qib7 10101 16 after after IN cord-005453-4057qib7 10101 17 HSCT HSCT NNP cord-005453-4057qib7 10101 18 revealed reveal VBD cord-005453-4057qib7 10101 19 that that IN cord-005453-4057qib7 10101 20 CD134 CD134 NNP cord-005453-4057qib7 10101 21 / / SYM cord-005453-4057qib7 10101 22 CD4 CD4 NNP cord-005453-4057qib7 10101 23 ratio ratio NN cord-005453-4057qib7 10101 24 was be VBD cord-005453-4057qib7 10101 25 significantly significantly RB cord-005453-4057qib7 10101 26 higher high JJR cord-005453-4057qib7 10101 27 in in IN cord-005453-4057qib7 10101 28 patients patient NNS cord-005453-4057qib7 10101 29 with with IN cord-005453-4057qib7 10101 30 HHV-6 HHV-6 NNP cord-005453-4057qib7 10101 31 reactivation reactivation NN cord-005453-4057qib7 10101 32 than than IN cord-005453-4057qib7 10101 33 those those DT cord-005453-4057qib7 10101 34 without without IN cord-005453-4057qib7 10101 35 before before IN cord-005453-4057qib7 10101 36 conditioning conditioning NN cord-005453-4057qib7 10102 1 ( ( -LRB- cord-005453-4057qib7 10102 2 In in IN cord-005453-4057qib7 10102 3 contrast contrast NN cord-005453-4057qib7 10102 4 , , , cord-005453-4057qib7 10102 5 there there EX cord-005453-4057qib7 10102 6 was be VBD cord-005453-4057qib7 10102 7 no no DT cord-005453-4057qib7 10102 8 such such JJ cord-005453-4057qib7 10102 9 significant significant JJ cord-005453-4057qib7 10102 10 difference difference NN cord-005453-4057qib7 10102 11 after after IN cord-005453-4057qib7 10102 12 transplant transplant NN cord-005453-4057qib7 10102 13 ( ( -LRB- cord-005453-4057qib7 10102 14 Days Days NNP cord-005453-4057qib7 10102 15 7 7 CD cord-005453-4057qib7 10102 16 to to IN cord-005453-4057qib7 10102 17 28 28 CD cord-005453-4057qib7 10102 18 ) ) -RRB- cord-005453-4057qib7 10102 19 . . . cord-005453-4057qib7 10103 1 In in IN cord-005453-4057qib7 10103 2 multivariate multivariate JJ cord-005453-4057qib7 10103 3 analysis analysis NN cord-005453-4057qib7 10103 4 , , , cord-005453-4057qib7 10103 5 higher high JJR cord-005453-4057qib7 10103 6 CD134 CD134 NNP cord-005453-4057qib7 10103 7 / / SYM cord-005453-4057qib7 10103 8 CD4 CD4 NNP cord-005453-4057qib7 10103 9 ratio ratio NN cord-005453-4057qib7 10103 10 before before IN cord-005453-4057qib7 10103 11 conditioning conditioning NN cord-005453-4057qib7 10103 12 ( ( -LRB- cord-005453-4057qib7 10103 13 odds odd NNS cord-005453-4057qib7 10103 14 ratio ratio NN cord-005453-4057qib7 10103 15 ( ( -LRB- cord-005453-4057qib7 10103 16 OR or NN cord-005453-4057qib7 10103 17 ) ) -RRB- cord-005453-4057qib7 10103 18 = = NFP cord-005453-4057qib7 10104 1 10.5 10.5 CD cord-005453-4057qib7 10104 2 , , , cord-005453-4057qib7 10104 3 95 95 CD cord-005453-4057qib7 10104 4 % % NN cord-005453-4057qib7 10104 5 confidence confidence NN cord-005453-4057qib7 10104 6 interval interval NN cord-005453-4057qib7 10104 7 ( ( -LRB- cord-005453-4057qib7 10104 8 CI CI NNP cord-005453-4057qib7 10104 9 ) ) -RRB- cord-005453-4057qib7 10104 10 : : : cord-005453-4057qib7 10105 1 1.3 1.3 CD cord-005453-4057qib7 10105 2 - - HYPH cord-005453-4057qib7 10105 3 85.1 85.1 CD cord-005453-4057qib7 10105 4 , , , cord-005453-4057qib7 10105 5 P p NN cord-005453-4057qib7 10105 6 = = SYM cord-005453-4057qib7 10105 7 0.03 0.03 CD cord-005453-4057qib7 10105 8 ) ) -RRB- cord-005453-4057qib7 10105 9 and and CC cord-005453-4057qib7 10105 10 stem stem NN cord-005453-4057qib7 10105 11 cell cell NN cord-005453-4057qib7 10105 12 source source NN cord-005453-4057qib7 10105 13 from from IN cord-005453-4057qib7 10105 14 human human JJ cord-005453-4057qib7 10105 15 leukocyte leukocyte NN cord-005453-4057qib7 10105 16 antigen antigen NN cord-005453-4057qib7 10105 17 mismatched mismatched JJ cord-005453-4057qib7 10105 18 donor donor NN cord-005453-4057qib7 10105 19 ( ( -LRB- cord-005453-4057qib7 10105 20 including include VBG cord-005453-4057qib7 10105 21 all all DT cord-005453-4057qib7 10105 22 cord cord NN cord-005453-4057qib7 10105 23 blood blood NN cord-005453-4057qib7 10105 24 transplantation transplantation NN cord-005453-4057qib7 10105 25 cases case NNS cord-005453-4057qib7 10105 26 ) ) -RRB- cord-005453-4057qib7 10105 27 ( ( -LRB- cord-005453-4057qib7 10105 28 OR or CC cord-005453-4057qib7 10105 29 = = SYM cord-005453-4057qib7 10105 30 15.4 15.4 CD cord-005453-4057qib7 10105 31 , , , cord-005453-4057qib7 10105 32 95%CI 95%ci CD cord-005453-4057qib7 10105 33 : : : cord-005453-4057qib7 10105 34 2.0 2.0 CD cord-005453-4057qib7 10105 35 - - SYM cord-005453-4057qib7 10105 36 121.0 121.0 CD cord-005453-4057qib7 10105 37 , , , cord-005453-4057qib7 10105 38 P p NN cord-005453-4057qib7 10105 39 = = SYM cord-005453-4057qib7 10105 40 0.04 0.04 CD cord-005453-4057qib7 10105 41 ) ) -RRB- cord-005453-4057qib7 10105 42 remained remain VBD cord-005453-4057qib7 10105 43 to to TO cord-005453-4057qib7 10105 44 be be VB cord-005453-4057qib7 10105 45 significantly significantly RB cord-005453-4057qib7 10105 46 associated associate VBN cord-005453-4057qib7 10105 47 with with IN cord-005453-4057qib7 10105 48 the the DT cord-005453-4057qib7 10105 49 incidence incidence NN cord-005453-4057qib7 10105 50 of of IN cord-005453-4057qib7 10105 51 HHV-6 HHV-6 NNP cord-005453-4057qib7 10105 52 reactivation reactivation NN cord-005453-4057qib7 10105 53 . . . cord-005453-4057qib7 10106 1 Conclusions conclusion NNS cord-005453-4057qib7 10106 2 : : : cord-005453-4057qib7 10107 1 Higher high JJR cord-005453-4057qib7 10107 2 CD134 cd134 CD cord-005453-4057qib7 10107 3 expression expression NN cord-005453-4057qib7 10107 4 rate rate NN cord-005453-4057qib7 10107 5 in in IN cord-005453-4057qib7 10107 6 CD4 CD4 NNP cord-005453-4057qib7 10107 7 + + CC cord-005453-4057qib7 10107 8 T t NN cord-005453-4057qib7 10107 9 cells cell NNS cord-005453-4057qib7 10107 10 before before IN cord-005453-4057qib7 10107 11 HSCT HSCT NNP cord-005453-4057qib7 10107 12 was be VBD cord-005453-4057qib7 10107 13 associated associate VBN cord-005453-4057qib7 10107 14 with with IN cord-005453-4057qib7 10107 15 higher high JJR cord-005453-4057qib7 10107 16 risk risk NN cord-005453-4057qib7 10107 17 of of IN cord-005453-4057qib7 10107 18 HHV-6 HHV-6 NNP cord-005453-4057qib7 10107 19 reactivation reactivation NN cord-005453-4057qib7 10107 20 , , , cord-005453-4057qib7 10107 21 which which WDT cord-005453-4057qib7 10107 22 could could MD cord-005453-4057qib7 10107 23 be be VB cord-005453-4057qib7 10107 24 a a DT cord-005453-4057qib7 10107 25 promising promising JJ cord-005453-4057qib7 10107 26 marker marker NN cord-005453-4057qib7 10107 27 for for IN cord-005453-4057qib7 10107 28 predicting predict VBG cord-005453-4057qib7 10107 29 HHV-6 HHV-6 NNP cord-005453-4057qib7 10107 30 reactivation reactivation NN cord-005453-4057qib7 10107 31 after after IN cord-005453-4057qib7 10107 32 allogeneic allogeneic NN cord-005453-4057qib7 10107 33 HSCT HSCT NNP cord-005453-4057qib7 10107 34 . . . cord-005453-4057qib7 10108 1 Careful careful JJ cord-005453-4057qib7 10108 2 observation observation NN cord-005453-4057qib7 10108 3 and and CC cord-005453-4057qib7 10108 4 monitoring monitoring NN cord-005453-4057qib7 10108 5 may may MD cord-005453-4057qib7 10108 6 be be VB cord-005453-4057qib7 10108 7 needed need VBN cord-005453-4057qib7 10108 8 in in IN cord-005453-4057qib7 10108 9 CD134 cd134 CD cord-005453-4057qib7 10108 10 highly highly RB cord-005453-4057qib7 10108 11 expressed express VBD cord-005453-4057qib7 10108 12 patients patient NNS cord-005453-4057qib7 10108 13 . . . cord-005453-4057qib7 10109 1 It -PRON- PRP cord-005453-4057qib7 10109 2 is be VBZ cord-005453-4057qib7 10109 3 a a DT cord-005453-4057qib7 10109 4 subject subject NN cord-005453-4057qib7 10109 5 of of IN cord-005453-4057qib7 10109 6 further further JJ cord-005453-4057qib7 10109 7 research research NN cord-005453-4057qib7 10109 8 to to TO cord-005453-4057qib7 10109 9 clarify clarify VB cord-005453-4057qib7 10109 10 the the DT cord-005453-4057qib7 10109 11 role role NN cord-005453-4057qib7 10109 12 of of IN cord-005453-4057qib7 10110 1 CD134 cd134 CD cord-005453-4057qib7 10110 2 + + CC cord-005453-4057qib7 10110 3 CD4 CD4 NNP cord-005453-4057qib7 10110 4 + + CC cord-005453-4057qib7 10110 5 T t NN cord-005453-4057qib7 10110 6 cell cell NN cord-005453-4057qib7 10110 7 in in IN cord-005453-4057qib7 10110 8 HHV-6 HHV-6 NNP cord-005453-4057qib7 10110 9 reactivation reactivation NN cord-005453-4057qib7 10110 10 . . . cord-005453-4057qib7 10111 1 Disclosure disclosure NN cord-005453-4057qib7 10111 2 : : : cord-005453-4057qib7 10111 3 Nothing nothing NN cord-005453-4057qib7 10111 4 to to TO cord-005453-4057qib7 10111 5 declare declare VB cord-005453-4057qib7 10111 6 . . . cord-005453-4057qib7 10112 1 Methods method NNS cord-005453-4057qib7 10112 2 : : : cord-005453-4057qib7 10113 1 Criteria criterion NNS cord-005453-4057qib7 10113 2 for for IN cord-005453-4057qib7 10113 3 the the DT cord-005453-4057qib7 10113 4 administration administration NN cord-005453-4057qib7 10113 5 of of IN cord-005453-4057qib7 10113 6 ICI ICI NNP cord-005453-4057qib7 10113 7 ( ( -LRB- cord-005453-4057qib7 10113 8 Vistide Vistide NNP cord-005453-4057qib7 10113 9 ) ) -RRB- cord-005453-4057qib7 10113 10 were be VBD cord-005453-4057qib7 10113 11 grade grade NN cord-005453-4057qib7 10113 12 III III NNP cord-005453-4057qib7 10113 13 - - HYPH cord-005453-4057qib7 10113 14 IV IV NNP cord-005453-4057qib7 10113 15 ( ( -LRB- cord-005453-4057qib7 10113 16 clinically clinically RB cord-005453-4057qib7 10113 17 significant significant JJ cord-005453-4057qib7 10113 18 hematuria hematuria NN cord-005453-4057qib7 10113 19 with with IN cord-005453-4057qib7 10113 20 clots clot NNS cord-005453-4057qib7 10113 21 ) ) -RRB- cord-005453-4057qib7 10114 1 BK BK NNP cord-005453-4057qib7 10114 2 - - HYPH cord-005453-4057qib7 10114 3 related relate VBN cord-005453-4057qib7 10114 4 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 10114 5 cystitis cystitis NN cord-005453-4057qib7 10114 6 after after IN cord-005453-4057qib7 10114 7 allo allo NN cord-005453-4057qib7 10114 8 - - HYPH cord-005453-4057qib7 10114 9 HCT HCT NNP cord-005453-4057qib7 10114 10 which which WDT cord-005453-4057qib7 10114 11 showed show VBD cord-005453-4057qib7 10114 12 no no DT cord-005453-4057qib7 10114 13 improvement improvement NN cord-005453-4057qib7 10114 14 after after IN cord-005453-4057qib7 10114 15 symptomatic symptomatic JJ cord-005453-4057qib7 10114 16 therapy therapy NN cord-005453-4057qib7 10114 17 with with IN cord-005453-4057qib7 10114 18 hyperhydration hyperhydration NN cord-005453-4057qib7 10114 19 and and CC cord-005453-4057qib7 10114 20 bladder bladder NN cord-005453-4057qib7 10114 21 irrigation irrigation NN cord-005453-4057qib7 10114 22 . . . cord-005453-4057qib7 10115 1 Cidofovir Cidofovir NNP cord-005453-4057qib7 10115 2 was be VBD cord-005453-4057qib7 10115 3 diluted dilute VBN cord-005453-4057qib7 10115 4 in in IN cord-005453-4057qib7 10115 5 100 100 CD cord-005453-4057qib7 10115 6 mL mL NNS cord-005453-4057qib7 10115 7 of of IN cord-005453-4057qib7 10115 8 normal normal JJ cord-005453-4057qib7 10115 9 saline saline NN cord-005453-4057qib7 10115 10 and and CC cord-005453-4057qib7 10115 11 installed instal VBN cord-005453-4057qib7 10115 12 via via IN cord-005453-4057qib7 10115 13 a a DT cord-005453-4057qib7 10115 14 Foley Foley NNP cord-005453-4057qib7 10115 15 catheter catheter NN cord-005453-4057qib7 10115 16 which which WDT cord-005453-4057qib7 10115 17 was be VBD cord-005453-4057qib7 10115 18 blocked block VBN cord-005453-4057qib7 10115 19 for for IN cord-005453-4057qib7 10115 20 1 1 CD cord-005453-4057qib7 10115 21 hour hour NN cord-005453-4057qib7 10115 22 . . . cord-005453-4057qib7 10116 1 Not not RB cord-005453-4057qib7 10116 2 knowing know VBG cord-005453-4057qib7 10116 3 the the DT cord-005453-4057qib7 10116 4 level level NN cord-005453-4057qib7 10116 5 of of IN cord-005453-4057qib7 10116 6 absorption absorption NN cord-005453-4057qib7 10116 7 of of IN cord-005453-4057qib7 10116 8 the the DT cord-005453-4057qib7 10116 9 drug drug NN cord-005453-4057qib7 10116 10 we -PRON- PRP cord-005453-4057qib7 10116 11 decided decide VBD cord-005453-4057qib7 10116 12 to to TO cord-005453-4057qib7 10116 13 give give VB cord-005453-4057qib7 10116 14 probenecid probenecid JJ cord-005453-4057qib7 10116 15 prophylaxis prophylaxis NN cord-005453-4057qib7 10116 16 in in IN cord-005453-4057qib7 10116 17 all all DT cord-005453-4057qib7 10116 18 patients patient NNS cord-005453-4057qib7 10116 19 . . . cord-005453-4057qib7 10117 1 ICI ICI NNP cord-005453-4057qib7 10117 2 was be VBD cord-005453-4057qib7 10117 3 repeated repeat VBN cord-005453-4057qib7 10117 4 weekly weekly RB cord-005453-4057qib7 10117 5 according accord VBG cord-005453-4057qib7 10117 6 to to IN cord-005453-4057qib7 10117 7 severity severity NN cord-005453-4057qib7 10117 8 of of IN cord-005453-4057qib7 10117 9 symptoms symptom NNS cord-005453-4057qib7 10117 10 . . . cord-005453-4057qib7 10118 1 Urine urine NN cord-005453-4057qib7 10118 2 and and CC cord-005453-4057qib7 10118 3 plasma plasma NN cord-005453-4057qib7 10118 4 BKV bkv NN cord-005453-4057qib7 10118 5 viral viral JJ cord-005453-4057qib7 10118 6 loads load NNS cord-005453-4057qib7 10118 7 were be VBD cord-005453-4057qib7 10118 8 quantified quantify VBN cord-005453-4057qib7 10118 9 by by IN cord-005453-4057qib7 10118 10 RQ rq NN cord-005453-4057qib7 10118 11 - - HYPH cord-005453-4057qib7 10118 12 PCR PCR NNP cord-005453-4057qib7 10118 13 Results result NNS cord-005453-4057qib7 10118 14 : : : cord-005453-4057qib7 10118 15 Six six CD cord-005453-4057qib7 10118 16 patients patient NNS cord-005453-4057qib7 10118 17 ( ( -LRB- cord-005453-4057qib7 10118 18 median median NN cord-005453-4057qib7 10118 19 38 38 CD cord-005453-4057qib7 10118 20 years year NNS cord-005453-4057qib7 10118 21 , , , cord-005453-4057qib7 10118 22 29 29 CD cord-005453-4057qib7 10118 23 - - SYM cord-005453-4057qib7 10118 24 51 51 CD cord-005453-4057qib7 10118 25 ) ) -RRB- cord-005453-4057qib7 10118 26 received receive VBD cord-005453-4057qib7 10118 27 ICI ICI NNP cord-005453-4057qib7 10118 28 after after IN cord-005453-4057qib7 10118 29 allo allo NN cord-005453-4057qib7 10118 30 - - HYPH cord-005453-4057qib7 10118 31 HCT hct NN cord-005453-4057qib7 10118 32 . . . cord-005453-4057qib7 10119 1 Patients patient NNS cord-005453-4057qib7 10119 2 had have VBD cord-005453-4057qib7 10119 3 haematological haematological JJ cord-005453-4057qib7 10119 4 malignancies malignancy NNS cord-005453-4057qib7 10119 5 ( ( -LRB- cord-005453-4057qib7 10119 6 AML AML NNP cord-005453-4057qib7 10119 7 2 2 CD cord-005453-4057qib7 10119 8 , , , cord-005453-4057qib7 10119 9 ALL all DT cord-005453-4057qib7 10119 10 3 3 CD cord-005453-4057qib7 10119 11 , , , cord-005453-4057qib7 10119 12 MDS MDS NNP cord-005453-4057qib7 10119 13 1 1 CD cord-005453-4057qib7 10119 14 ) ) -RRB- cord-005453-4057qib7 10119 15 , , , cord-005453-4057qib7 10119 16 received receive VBD cord-005453-4057qib7 10119 17 busilfex busilfex NNP cord-005453-4057qib7 10119 18 - - HYPH cord-005453-4057qib7 10119 19 based base VBN cord-005453-4057qib7 10119 20 myeloablative myeloablative NNP cord-005453-4057qib7 10119 21 conditioning conditioning NN cord-005453-4057qib7 10119 22 and and CC cord-005453-4057qib7 10119 23 a a DT cord-005453-4057qib7 10119 24 graft graft NN cord-005453-4057qib7 10119 25 ( ( -LRB- cord-005453-4057qib7 10119 26 PBSC PBSC NNP cord-005453-4057qib7 10119 27 5 5 CD cord-005453-4057qib7 10119 28 , , , cord-005453-4057qib7 10119 29 BM BM NNP cord-005453-4057qib7 10119 30 1 1 CD cord-005453-4057qib7 10119 31 ) ) -RRB- cord-005453-4057qib7 10119 32 from from IN cord-005453-4057qib7 10119 33 a a DT cord-005453-4057qib7 10119 34 7/8 7/8 CD cord-005453-4057qib7 10119 35 HLA HLA NNP cord-005453-4057qib7 10119 36 - - HYPH cord-005453-4057qib7 10119 37 matched match VBN cord-005453-4057qib7 10119 38 ( ( -LRB- cord-005453-4057qib7 10119 39 4pts 4pts CD cord-005453-4057qib7 10119 40 ) ) -RRB- cord-005453-4057qib7 10119 41 , , , cord-005453-4057qib7 10119 42 8/8 8/8 CD cord-005453-4057qib7 10119 43 ( ( -LRB- cord-005453-4057qib7 10119 44 1pt 1pt NNP cord-005453-4057qib7 10119 45 ) ) -RRB- cord-005453-4057qib7 10119 46 or or CC cord-005453-4057qib7 10119 47 haploidentical haploidentical JJ cord-005453-4057qib7 10119 48 ( ( -LRB- cord-005453-4057qib7 10119 49 1pt 1pt NNP cord-005453-4057qib7 10119 50 ) ) -RRB- cord-005453-4057qib7 10119 51 donor donor NN cord-005453-4057qib7 10119 52 . . . cord-005453-4057qib7 10120 1 Median median JJ cord-005453-4057qib7 10120 2 time time NN cord-005453-4057qib7 10120 3 for for IN cord-005453-4057qib7 10120 4 the the DT cord-005453-4057qib7 10120 5 onset onset NN cord-005453-4057qib7 10120 6 of of IN cord-005453-4057qib7 10120 7 BKV BKV NNP cord-005453-4057qib7 10120 8 - - HYPH cord-005453-4057qib7 10120 9 HC HC NNP cord-005453-4057qib7 10120 10 after after IN cord-005453-4057qib7 10120 11 allo allo NN cord-005453-4057qib7 10120 12 - - HYPH cord-005453-4057qib7 10120 13 HCT HCT NNP cord-005453-4057qib7 10120 14 were be VBD cord-005453-4057qib7 10120 15 53.5 53.5 CD cord-005453-4057qib7 10120 16 days day NNS cord-005453-4057qib7 10121 1 ( ( -LRB- cord-005453-4057qib7 10121 2 range range NNP cord-005453-4057qib7 10121 3 32 32 CD cord-005453-4057qib7 10121 4 - - SYM cord-005453-4057qib7 10121 5 117 117 CD cord-005453-4057qib7 10121 6 ) ) -RRB- cord-005453-4057qib7 10121 7 . . . cord-005453-4057qib7 10122 1 All all DT cord-005453-4057qib7 10122 2 patients patient NNS cord-005453-4057qib7 10122 3 were be VBD cord-005453-4057qib7 10122 4 under under IN cord-005453-4057qib7 10122 5 standard standard JJ cord-005453-4057qib7 10122 6 cyclosporine cyclosporine JJ cord-005453-4057qib7 10122 7 prophylaxis prophylaxis NN cord-005453-4057qib7 10122 8 and and CC cord-005453-4057qib7 10122 9 none none NN cord-005453-4057qib7 10122 10 of of IN cord-005453-4057qib7 10122 11 the the DT cord-005453-4057qib7 10122 12 patients patient NNS cord-005453-4057qib7 10122 13 had have VBD cord-005453-4057qib7 10122 14 any any DT cord-005453-4057qib7 10122 15 signs sign NNS cord-005453-4057qib7 10122 16 of of IN cord-005453-4057qib7 10122 17 acute acute JJ cord-005453-4057qib7 10122 18 GvHD gvhd NN cord-005453-4057qib7 10122 19 at at IN cord-005453-4057qib7 10122 20 the the DT cord-005453-4057qib7 10122 21 time time NN cord-005453-4057qib7 10122 22 of of IN cord-005453-4057qib7 10122 23 onset onset NN cord-005453-4057qib7 10122 24 of of IN cord-005453-4057qib7 10122 25 HC HC NNP cord-005453-4057qib7 10122 26 . . . cord-005453-4057qib7 10123 1 The the DT cord-005453-4057qib7 10123 2 median median JJ cord-005453-4057qib7 10123 3 PCR PCR NNP cord-005453-4057qib7 10123 4 - - HYPH cord-005453-4057qib7 10123 5 BKV BKV NNP cord-005453-4057qib7 10123 6 viral viral JJ cord-005453-4057qib7 10123 7 load load NN cord-005453-4057qib7 10123 8 at at IN cord-005453-4057qib7 10123 9 the the DT cord-005453-4057qib7 10123 10 onset onset NN cord-005453-4057qib7 10123 11 of of IN cord-005453-4057qib7 10123 12 BKV BKV NNP cord-005453-4057qib7 10123 13 - - HYPH cord-005453-4057qib7 10123 14 HC HC NNP cord-005453-4057qib7 10123 15 in in IN cord-005453-4057qib7 10123 16 urine urine NN cord-005453-4057qib7 10123 17 and and CC cord-005453-4057qib7 10123 18 plasma plasma NN cord-005453-4057qib7 10123 19 were be VBD cord-005453-4057qib7 10123 20 5.75x10 5.75x10 CD cord-005453-4057qib7 10123 21 8 8 CD cord-005453-4057qib7 10124 1 ( ( -LRB- cord-005453-4057qib7 10124 2 range range VBP cord-005453-4057qib7 10124 3 0.15x10 0.15x10 CD cord-005453-4057qib7 10124 4 8 8 CD cord-005453-4057qib7 10124 5 -59x10 -59x10 SYM cord-005453-4057qib7 10124 6 8 8 CD cord-005453-4057qib7 10124 7 ) ) -RRB- cord-005453-4057qib7 10125 1 and and CC cord-005453-4057qib7 10125 2 141.5 141.5 CD cord-005453-4057qib7 10125 3 ( ( -LRB- cord-005453-4057qib7 10125 4 range range NN cord-005453-4057qib7 10125 5 0 0 CD cord-005453-4057qib7 10125 6 - - HYPH cord-005453-4057qib7 10125 7 255 255 CD cord-005453-4057qib7 10125 8 ) ) -RRB- cord-005453-4057qib7 10125 9 , , , cord-005453-4057qib7 10125 10 respectively respectively RB cord-005453-4057qib7 10125 11 . . . cord-005453-4057qib7 10126 1 The the DT cord-005453-4057qib7 10126 2 median median JJ cord-005453-4057qib7 10126 3 maximum maximum JJ cord-005453-4057qib7 10126 4 PCR PCR NNP cord-005453-4057qib7 10126 5 - - HYPH cord-005453-4057qib7 10126 6 BKV BKV NNP cord-005453-4057qib7 10126 7 viral viral JJ cord-005453-4057qib7 10126 8 load load NN cord-005453-4057qib7 10126 9 in in IN cord-005453-4057qib7 10126 10 urine urine NN cord-005453-4057qib7 10126 11 and and CC cord-005453-4057qib7 10126 12 plasma plasma NN cord-005453-4057qib7 10126 13 were be VBD cord-005453-4057qib7 10126 14 37.5x10 37.5x10 CD cord-005453-4057qib7 10126 15 8 8 CD cord-005453-4057qib7 10127 1 ( ( -LRB- cord-005453-4057qib7 10127 2 range range NN cord-005453-4057qib7 10127 3 4.7x10 4.7x10 CD cord-005453-4057qib7 10127 4 8 8 CD cord-005453-4057qib7 10127 5 -450x10 -450x10 SYM cord-005453-4057qib7 10127 6 8 8 CD cord-005453-4057qib7 10127 7 ) ) -RRB- cord-005453-4057qib7 10127 8 and and CC cord-005453-4057qib7 10127 9 1.100 1.100 CD cord-005453-4057qib7 10128 1 ( ( -LRB- cord-005453-4057qib7 10128 2 range range NN cord-005453-4057qib7 10128 3 0 0 CD cord-005453-4057qib7 10128 4 - - CD cord-005453-4057qib7 10128 5 400.000 400.000 CD cord-005453-4057qib7 10128 6 ) ) -RRB- cord-005453-4057qib7 10128 7 , , , cord-005453-4057qib7 10128 8 respectively respectively RB cord-005453-4057qib7 10128 9 . . . cord-005453-4057qib7 10129 1 Five five CD cord-005453-4057qib7 10129 2 patients patient NNS cord-005453-4057qib7 10129 3 had have VBD cord-005453-4057qib7 10129 4 impaired impair VBN cord-005453-4057qib7 10129 5 renal renal JJ cord-005453-4057qib7 10129 6 function function NN cord-005453-4057qib7 10129 7 ( ( -LRB- cord-005453-4057qib7 10129 8 median median NN cord-005453-4057qib7 10129 9 eGFR egfr NN cord-005453-4057qib7 10129 10 49 49 CD cord-005453-4057qib7 10129 11 ml ml NNS cord-005453-4057qib7 10129 12 / / SYM cord-005453-4057qib7 10129 13 min min NN cord-005453-4057qib7 10129 14 , , , cord-005453-4057qib7 10129 15 range range VBP cord-005453-4057qib7 10129 16 33 33 CD cord-005453-4057qib7 10129 17 - - SYM cord-005453-4057qib7 10129 18 53 53 CD cord-005453-4057qib7 10129 19 ) ) -RRB- cord-005453-4057qib7 10129 20 at at IN cord-005453-4057qib7 10129 21 first first JJ cord-005453-4057qib7 10129 22 ICI ICI NNP cord-005453-4057qib7 10129 23 which which WDT cord-005453-4057qib7 10129 24 was be VBD cord-005453-4057qib7 10129 25 probably probably RB cord-005453-4057qib7 10129 26 multifactorial multifactorial JJ cord-005453-4057qib7 10129 27 . . . cord-005453-4057qib7 10130 1 The the DT cord-005453-4057qib7 10130 2 median median JJ cord-005453-4057qib7 10130 3 dose dose NN cord-005453-4057qib7 10130 4 of of IN cord-005453-4057qib7 10130 5 intravesical intravesical JJ cord-005453-4057qib7 10130 6 cidofovir cidofovir NNS cord-005453-4057qib7 10130 7 was be VBD cord-005453-4057qib7 10130 8 5 5 CD cord-005453-4057qib7 10130 9 mg mg NNP cord-005453-4057qib7 10130 10 / / SYM cord-005453-4057qib7 10130 11 kg kg NNP cord-005453-4057qib7 10130 12 ( ( -LRB- cord-005453-4057qib7 10130 13 range range VBP cord-005453-4057qib7 10130 14 2.5 2.5 CD cord-005453-4057qib7 10130 15 - - SYM cord-005453-4057qib7 10130 16 5 5 CD cord-005453-4057qib7 10130 17 mg mg NNP cord-005453-4057qib7 10130 18 / / SYM cord-005453-4057qib7 10130 19 kg kg NNP cord-005453-4057qib7 10130 20 ) ) -RRB- cord-005453-4057qib7 10130 21 and and CC cord-005453-4057qib7 10130 22 a a DT cord-005453-4057qib7 10130 23 median median JJ cord-005453-4057qib7 10130 24 number number NN cord-005453-4057qib7 10130 25 of of IN cord-005453-4057qib7 10130 26 3.5 3.5 CD cord-005453-4057qib7 10130 27 instillations instillation NNS cord-005453-4057qib7 10130 28 ( ( -LRB- cord-005453-4057qib7 10130 29 range range NNP cord-005453-4057qib7 10130 30 2 2 CD cord-005453-4057qib7 10130 31 - - SYM cord-005453-4057qib7 10130 32 7 7 CD cord-005453-4057qib7 10130 33 ) ) -RRB- cord-005453-4057qib7 10130 34 were be VBD cord-005453-4057qib7 10130 35 given give VBN cord-005453-4057qib7 10130 36 . . . cord-005453-4057qib7 10131 1 In in IN cord-005453-4057qib7 10131 2 5/6 5/6 CD cord-005453-4057qib7 10131 3 cases case NNS cord-005453-4057qib7 10131 4 symptoms symptom NNS cord-005453-4057qib7 10131 5 of of IN cord-005453-4057qib7 10131 6 cystitis cystitis NN cord-005453-4057qib7 10131 7 improved improve VBD cord-005453-4057qib7 10131 8 dramatically dramatically RB cord-005453-4057qib7 10131 9 and and CC cord-005453-4057qib7 10131 10 hematuria hematuria NN cord-005453-4057qib7 10131 11 resolved resolve VBN cord-005453-4057qib7 10131 12 . . . cord-005453-4057qib7 10132 1 Virological virological JJ cord-005453-4057qib7 10132 2 response response NN cord-005453-4057qib7 10132 3 ( ( -LRB- cord-005453-4057qib7 10132 4 at at IN cord-005453-4057qib7 10132 5 least least JJS cord-005453-4057qib7 10132 6 1 1 CD cord-005453-4057qib7 10132 7 log log NN cord-005453-4057qib7 10132 8 reduction reduction NN cord-005453-4057qib7 10132 9 ) ) -RRB- cord-005453-4057qib7 10132 10 was be VBD cord-005453-4057qib7 10132 11 observed observe VBN cord-005453-4057qib7 10132 12 in in IN cord-005453-4057qib7 10132 13 all all DT cord-005453-4057qib7 10132 14 5 5 CD cord-005453-4057qib7 10132 15 cases case NNS cord-005453-4057qib7 10132 16 . . . cord-005453-4057qib7 10133 1 Two two CD cord-005453-4057qib7 10133 2 patients patient NNS cord-005453-4057qib7 10133 3 experienced experience VBD cord-005453-4057qib7 10133 4 relapse relapse NN cord-005453-4057qib7 10133 5 of of IN cord-005453-4057qib7 10133 6 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 10133 7 cystitis cystitis NN cord-005453-4057qib7 10133 8 and and CC cord-005453-4057qib7 10133 9 were be VBD cord-005453-4057qib7 10133 10 retreated retreat VBN cord-005453-4057qib7 10133 11 with with IN cord-005453-4057qib7 10133 12 ICI ICI NNP cord-005453-4057qib7 10133 13 which which WDT cord-005453-4057qib7 10133 14 resulted result VBD cord-005453-4057qib7 10133 15 in in IN cord-005453-4057qib7 10133 16 resolution resolution NN cord-005453-4057qib7 10133 17 of of IN cord-005453-4057qib7 10133 18 the the DT cord-005453-4057qib7 10133 19 symptoms symptom NNS cord-005453-4057qib7 10133 20 and and CC cord-005453-4057qib7 10133 21 the the DT cord-005453-4057qib7 10133 22 hematuria hematuria NN cord-005453-4057qib7 10133 23 . . . cord-005453-4057qib7 10134 1 No no DT cord-005453-4057qib7 10134 2 deterioration deterioration NN cord-005453-4057qib7 10134 3 of of IN cord-005453-4057qib7 10134 4 renal renal JJ cord-005453-4057qib7 10134 5 function function NN cord-005453-4057qib7 10134 6 of of IN cord-005453-4057qib7 10134 7 other other JJ cord-005453-4057qib7 10134 8 systemic systemic JJ cord-005453-4057qib7 10134 9 adverse adverse JJ cord-005453-4057qib7 10134 10 effects effect NNS cord-005453-4057qib7 10134 11 were be VBD cord-005453-4057qib7 10134 12 observed observe VBN cord-005453-4057qib7 10134 13 . . . cord-005453-4057qib7 10135 1 After after IN cord-005453-4057qib7 10135 2 a a DT cord-005453-4057qib7 10135 3 median median NN cord-005453-4057qib7 10135 4 follow follow NN cord-005453-4057qib7 10135 5 up up IN cord-005453-4057qib7 10135 6 of of IN cord-005453-4057qib7 10135 7 190.5 190.5 CD cord-005453-4057qib7 10135 8 days day NNS cord-005453-4057qib7 10135 9 after after IN cord-005453-4057qib7 10135 10 transplantation transplantation NN cord-005453-4057qib7 10135 11 ( ( -LRB- cord-005453-4057qib7 10135 12 range range NNP cord-005453-4057qib7 10135 13 105 105 CD cord-005453-4057qib7 10135 14 - - SYM cord-005453-4057qib7 10135 15 360 360 CD cord-005453-4057qib7 10135 16 ) ) -RRB- cord-005453-4057qib7 10135 17 , , , cord-005453-4057qib7 10135 18 3/6 3/6 CD cord-005453-4057qib7 10135 19 patients patient NNS cord-005453-4057qib7 10135 20 are be VBP cord-005453-4057qib7 10135 21 alive alive JJ cord-005453-4057qib7 10135 22 without without IN cord-005453-4057qib7 10135 23 cystitis cystitis NN cord-005453-4057qib7 10135 24 symptomatology symptomatology NN cord-005453-4057qib7 10135 25 and and CC cord-005453-4057qib7 10135 26 3 3 CD cord-005453-4057qib7 10135 27 died die VBD cord-005453-4057qib7 10135 28 ( ( -LRB- cord-005453-4057qib7 10135 29 1 1 CD cord-005453-4057qib7 10135 30 due due JJ cord-005453-4057qib7 10135 31 to to IN cord-005453-4057qib7 10135 32 relapse relapse NN cord-005453-4057qib7 10135 33 and and CC cord-005453-4057qib7 10135 34 2 2 CD cord-005453-4057qib7 10135 35 due due IN cord-005453-4057qib7 10135 36 to to IN cord-005453-4057qib7 10135 37 TRM TRM NNP cord-005453-4057qib7 10135 38 ) ) -RRB- cord-005453-4057qib7 10135 39 . . . cord-005453-4057qib7 10136 1 Conclusions conclusion NNS cord-005453-4057qib7 10136 2 : : : cord-005453-4057qib7 10137 1 In in IN cord-005453-4057qib7 10137 2 this this DT cord-005453-4057qib7 10137 3 retrospective retrospective JJ cord-005453-4057qib7 10137 4 study study NN cord-005453-4057qib7 10137 5 we -PRON- PRP cord-005453-4057qib7 10137 6 propose propose VBP cord-005453-4057qib7 10137 7 that that IN cord-005453-4057qib7 10137 8 local local JJ cord-005453-4057qib7 10137 9 therapy therapy NN cord-005453-4057qib7 10137 10 of of IN cord-005453-4057qib7 10137 11 BKV BKV NNP cord-005453-4057qib7 10137 12 - - HYPH cord-005453-4057qib7 10137 13 HC HC NNP cord-005453-4057qib7 10137 14 with with IN cord-005453-4057qib7 10137 15 ICI ICI NNP cord-005453-4057qib7 10137 16 is be VBZ cord-005453-4057qib7 10137 17 safe safe JJ cord-005453-4057qib7 10137 18 and and CC cord-005453-4057qib7 10137 19 has have VBZ cord-005453-4057qib7 10137 20 high high JJ cord-005453-4057qib7 10137 21 clinical clinical JJ cord-005453-4057qib7 10137 22 and and CC cord-005453-4057qib7 10137 23 virological virological JJ cord-005453-4057qib7 10137 24 response response NN cord-005453-4057qib7 10137 25 rates rate NNS cord-005453-4057qib7 10137 26 . . . cord-005453-4057qib7 10138 1 The the DT cord-005453-4057qib7 10138 2 administration administration NN cord-005453-4057qib7 10138 3 of of IN cord-005453-4057qib7 10138 4 ICI ICI NNP cord-005453-4057qib7 10138 5 after after IN cord-005453-4057qib7 10138 6 allo allo NN cord-005453-4057qib7 10138 7 - - HYPH cord-005453-4057qib7 10138 8 HCT hct NN cord-005453-4057qib7 10138 9 should should MD cord-005453-4057qib7 10138 10 be be VB cord-005453-4057qib7 10138 11 controlled control VBN cord-005453-4057qib7 10138 12 in in IN cord-005453-4057qib7 10138 13 prospective prospective JJ cord-005453-4057qib7 10138 14 randomized randomized JJ cord-005453-4057qib7 10138 15 trials trial NNS cord-005453-4057qib7 10138 16 . . . cord-005453-4057qib7 10139 1 Disclosure disclosure NN cord-005453-4057qib7 10139 2 : : : cord-005453-4057qib7 10139 3 Nothing nothing NN cord-005453-4057qib7 10139 4 to to TO cord-005453-4057qib7 10139 5 declare declare VB cord-005453-4057qib7 10139 6 Background background NN cord-005453-4057qib7 10139 7 : : : cord-005453-4057qib7 10140 1 Since since IN cord-005453-4057qib7 10140 2 CMV CMV NNP cord-005453-4057qib7 10140 3 - - HYPH cord-005453-4057qib7 10140 4 preemptive preemptive JJ cord-005453-4057qib7 10140 5 therapy therapy NN cord-005453-4057qib7 10140 6 approach approach NN cord-005453-4057qib7 10140 7 was be VBD cord-005453-4057qib7 10140 8 implemented implement VBN cord-005453-4057qib7 10140 9 , , , cord-005453-4057qib7 10140 10 CMV CMV NNP cord-005453-4057qib7 10140 11 disease disease NN cord-005453-4057qib7 10140 12 frequency frequency NN cord-005453-4057qib7 10140 13 is be VBZ cord-005453-4057qib7 10140 14 very very RB cord-005453-4057qib7 10140 15 low low JJ cord-005453-4057qib7 10140 16 . . . cord-005453-4057qib7 10141 1 However however RB cord-005453-4057qib7 10141 2 , , , cord-005453-4057qib7 10141 3 CMV CMV NNP cord-005453-4057qib7 10141 4 reactivation reactivation NN cord-005453-4057qib7 10141 5 and and CC cord-005453-4057qib7 10141 6 the the DT cord-005453-4057qib7 10141 7 need need NN cord-005453-4057qib7 10141 8 of of IN cord-005453-4057qib7 10141 9 using use VBG cord-005453-4057qib7 10141 10 nephrotoxic nephrotoxic NNP cord-005453-4057qib7 10141 11 plus plus CC cord-005453-4057qib7 10141 12 / / SYM cord-005453-4057qib7 10141 13 less less JJR cord-005453-4057qib7 10141 14 myelotoxic myelotoxic JJ cord-005453-4057qib7 10141 15 drugs drug NNS cord-005453-4057qib7 10141 16 is be VBZ cord-005453-4057qib7 10141 17 very very RB cord-005453-4057qib7 10141 18 frequent frequent JJ cord-005453-4057qib7 10141 19 . . . cord-005453-4057qib7 10142 1 In in IN cord-005453-4057qib7 10142 2 addition addition NN cord-005453-4057qib7 10142 3 to to IN cord-005453-4057qib7 10142 4 the the DT cord-005453-4057qib7 10142 5 toxicity toxicity NN cord-005453-4057qib7 10142 6 of of IN cord-005453-4057qib7 10142 7 the the DT cord-005453-4057qib7 10142 8 medications medication NNS cord-005453-4057qib7 10142 9 to to TO cord-005453-4057qib7 10142 10 avoid avoid VB cord-005453-4057qib7 10142 11 CMV CMV NNP cord-005453-4057qib7 10142 12 disease disease NN cord-005453-4057qib7 10142 13 , , , cord-005453-4057qib7 10142 14 other other JJ cord-005453-4057qib7 10142 15 potential potential JJ cord-005453-4057qib7 10142 16 adverse adverse JJ cord-005453-4057qib7 10142 17 effects effect NNS cord-005453-4057qib7 10142 18 of of IN cord-005453-4057qib7 10142 19 CMV CMV NNP cord-005453-4057qib7 10142 20 have have VBP cord-005453-4057qib7 10142 21 been be VBN cord-005453-4057qib7 10142 22 mentioned mention VBN cord-005453-4057qib7 10142 23 in in IN cord-005453-4057qib7 10142 24 medical medical JJ cord-005453-4057qib7 10142 25 literature literature NN cord-005453-4057qib7 10142 26 . . . cord-005453-4057qib7 10143 1 In in IN cord-005453-4057qib7 10143 2 this this DT cord-005453-4057qib7 10143 3 study study NN cord-005453-4057qib7 10143 4 , , , cord-005453-4057qib7 10143 5 we -PRON- PRP cord-005453-4057qib7 10143 6 wanted want VBD cord-005453-4057qib7 10143 7 to to TO cord-005453-4057qib7 10143 8 estimate estimate VB cord-005453-4057qib7 10143 9 how how WRB cord-005453-4057qib7 10143 10 recipient recipient NN cord-005453-4057qib7 10143 11 / / SYM cord-005453-4057qib7 10143 12 donor donor NN cord-005453-4057qib7 10143 13 serologic serologic NN cord-005453-4057qib7 10143 14 status status NN cord-005453-4057qib7 10143 15 influences influence VBZ cord-005453-4057qib7 10143 16 the the DT cord-005453-4057qib7 10143 17 outcome outcome NN cord-005453-4057qib7 10143 18 of of IN cord-005453-4057qib7 10143 19 allo allo NN cord-005453-4057qib7 10143 20 - - HYPH cord-005453-4057qib7 10143 21 HSCT HSCT NNP cord-005453-4057qib7 10143 22 in in IN cord-005453-4057qib7 10143 23 our -PRON- PRP$ cord-005453-4057qib7 10143 24 most most RBS cord-005453-4057qib7 10143 25 recent recent JJ cord-005453-4057qib7 10143 26 series series NN cord-005453-4057qib7 10143 27 of of IN cord-005453-4057qib7 10143 28 patients patient NNS cord-005453-4057qib7 10143 29 . . . cord-005453-4057qib7 10144 1 Methods method NNS cord-005453-4057qib7 10144 2 : : : cord-005453-4057qib7 10145 1 the the DT cord-005453-4057qib7 10145 2 population population NN cord-005453-4057qib7 10145 3 analyzed analyze VBD cord-005453-4057qib7 10145 4 for for IN cord-005453-4057qib7 10145 5 this this DT cord-005453-4057qib7 10145 6 report report NN cord-005453-4057qib7 10145 7 is be VBZ cord-005453-4057qib7 10145 8 the the DT cord-005453-4057qib7 10145 9 all all DT cord-005453-4057qib7 10145 10 224 224 CD cord-005453-4057qib7 10145 11 patients patient NNS cord-005453-4057qib7 10145 12 who who WP cord-005453-4057qib7 10145 13 underwent undergo VBD cord-005453-4057qib7 10145 14 allo allo NN cord-005453-4057qib7 10145 15 - - HYPH cord-005453-4057qib7 10145 16 HSCT HSCT NNP cord-005453-4057qib7 10145 17 during during IN cord-005453-4057qib7 10145 18 the the DT cord-005453-4057qib7 10145 19 4-year 4-year JJ cord-005453-4057qib7 10145 20 period period NN cord-005453-4057qib7 10145 21 from from IN cord-005453-4057qib7 10145 22 October October NNP cord-005453-4057qib7 10145 23 2014 2014 CD cord-005453-4057qib7 10145 24 September September NNP cord-005453-4057qib7 10145 25 2018 2018 CD cord-005453-4057qib7 10145 26 in in IN cord-005453-4057qib7 10145 27 our -PRON- PRP$ cord-005453-4057qib7 10145 28 Unit unit NN cord-005453-4057qib7 10145 29 . . . cord-005453-4057qib7 10146 1 Median median JJ cord-005453-4057qib7 10146 2 age age NN cord-005453-4057qib7 10146 3 at at IN cord-005453-4057qib7 10146 4 transplant transplant NN cord-005453-4057qib7 10146 5 was be VBD cord-005453-4057qib7 10146 6 52 52 CD cord-005453-4057qib7 10146 7 years year NNS cord-005453-4057qib7 10147 1 ( ( -LRB- cord-005453-4057qib7 10147 2 range range NN cord-005453-4057qib7 10147 3 : : : cord-005453-4057qib7 10147 4 7 7 CD cord-005453-4057qib7 10147 5 - - SYM cord-005453-4057qib7 10147 6 69 69 CD cord-005453-4057qib7 10147 7 ) ) -RRB- cord-005453-4057qib7 10147 8 . . . cord-005453-4057qib7 10148 1 One one CD cord-005453-4057qib7 10148 2 hundred hundred CD cord-005453-4057qib7 10148 3 and and CC cord-005453-4057qib7 10148 4 thirty thirty CD cord-005453-4057qib7 10148 5 were be VBD cord-005453-4057qib7 10148 6 male male JJ cord-005453-4057qib7 10148 7 ( ( -LRB- cord-005453-4057qib7 10148 8 58 58 CD cord-005453-4057qib7 10148 9 % % NN cord-005453-4057qib7 10148 10 ) ) -RRB- cord-005453-4057qib7 10148 11 and and CC cord-005453-4057qib7 10148 12 94 94 CD cord-005453-4057qib7 10148 13 were be VBD cord-005453-4057qib7 10148 14 female female JJ cord-005453-4057qib7 10148 15 ( ( -LRB- cord-005453-4057qib7 10148 16 42 42 CD cord-005453-4057qib7 10148 17 % % NN cord-005453-4057qib7 10148 18 ) ) -RRB- cord-005453-4057qib7 10148 19 . . . cord-005453-4057qib7 10149 1 Baseline baseline JJ cord-005453-4057qib7 10149 2 diseases disease NNS cord-005453-4057qib7 10149 3 were be VBD cord-005453-4057qib7 10149 4 : : : cord-005453-4057qib7 10149 5 83 83 CD cord-005453-4057qib7 10149 6 AML AML NNP cord-005453-4057qib7 10149 7 , , , cord-005453-4057qib7 10149 8 51 51 CD cord-005453-4057qib7 10149 9 LPD LPD NNP cord-005453-4057qib7 10149 10 , , , cord-005453-4057qib7 10149 11 29 29 CD cord-005453-4057qib7 10149 12 ALL all DT cord-005453-4057qib7 10149 13 , , , cord-005453-4057qib7 10149 14 29 29 CD cord-005453-4057qib7 10149 15 MDS MDS NNP cord-005453-4057qib7 10149 16 , , , cord-005453-4057qib7 10149 17 14 14 CD cord-005453-4057qib7 10149 18 MPD MPD NNP cord-005453-4057qib7 10149 19 , , , cord-005453-4057qib7 10149 20 12 12 CD cord-005453-4057qib7 10149 21 MM MM NNP cord-005453-4057qib7 10149 22 , , , cord-005453-4057qib7 10149 23 and and CC cord-005453-4057qib7 10149 24 6 6 CD cord-005453-4057qib7 10149 25 BMF bmf NN cord-005453-4057qib7 10149 26 . . . cord-005453-4057qib7 10150 1 Donor donor NN cord-005453-4057qib7 10150 2 was be VBD cord-005453-4057qib7 10150 3 unrelated unrelated JJ cord-005453-4057qib7 10150 4 in in IN cord-005453-4057qib7 10150 5 120 120 CD cord-005453-4057qib7 10150 6 transplants transplant NNS cord-005453-4057qib7 10150 7 ( ( -LRB- cord-005453-4057qib7 10150 8 54,5 54,5 CD cord-005453-4057qib7 10150 9 % % NN cord-005453-4057qib7 10150 10 ) ) -RRB- cord-005453-4057qib7 10150 11 and and CC cord-005453-4057qib7 10150 12 was be VBD cord-005453-4057qib7 10150 13 family family NN cord-005453-4057qib7 10150 14 in in IN cord-005453-4057qib7 10150 15 104 104 CD cord-005453-4057qib7 10150 16 ( ( -LRB- cord-005453-4057qib7 10150 17 45,5 45,5 CD cord-005453-4057qib7 10150 18 % % NN cord-005453-4057qib7 10150 19 ) ) -RRB- cord-005453-4057qib7 10150 20 ( ( -LRB- cord-005453-4057qib7 10150 21 including include VBG cord-005453-4057qib7 10150 22 34 34 CD cord-005453-4057qib7 10150 23 haplo haplo NN cord-005453-4057qib7 10150 24 - - HYPH cord-005453-4057qib7 10150 25 identical identical JJ cord-005453-4057qib7 10150 26 ) ) -RRB- cord-005453-4057qib7 10150 27 . . . cord-005453-4057qib7 10151 1 Conditioning conditioning NN cord-005453-4057qib7 10151 2 regimen regimen NN cord-005453-4057qib7 10151 3 was be VBD cord-005453-4057qib7 10151 4 RIC RIC NNP cord-005453-4057qib7 10151 5 in in IN cord-005453-4057qib7 10151 6 121 121 CD cord-005453-4057qib7 10151 7 procedures procedure NNS cord-005453-4057qib7 10151 8 ( ( -LRB- cord-005453-4057qib7 10151 9 54 54 CD cord-005453-4057qib7 10151 10 % % NN cord-005453-4057qib7 10151 11 ) ) -RRB- cord-005453-4057qib7 10151 12 and and CC cord-005453-4057qib7 10151 13 intensive intensive JJ cord-005453-4057qib7 10151 14 in in IN cord-005453-4057qib7 10151 15 103 103 CD cord-005453-4057qib7 10151 16 ( ( -LRB- cord-005453-4057qib7 10151 17 46 46 CD cord-005453-4057qib7 10151 18 % % NN cord-005453-4057qib7 10151 19 ) ) -RRB- cord-005453-4057qib7 10151 20 . . . cord-005453-4057qib7 10152 1 Stem stem JJ cord-005453-4057qib7 10152 2 cell cell NN cord-005453-4057qib7 10152 3 source source NN cord-005453-4057qib7 10152 4 was be VBD cord-005453-4057qib7 10152 5 PB PB NNP cord-005453-4057qib7 10152 6 in in IN cord-005453-4057qib7 10152 7 210 210 CD cord-005453-4057qib7 10152 8 ( ( -LRB- cord-005453-4057qib7 10152 9 93,7 93,7 CD cord-005453-4057qib7 10152 10 % % NN cord-005453-4057qib7 10152 11 ) ) -RRB- cord-005453-4057qib7 10152 12 and and CC cord-005453-4057qib7 10152 13 BM BM NNP cord-005453-4057qib7 10152 14 in in IN cord-005453-4057qib7 10152 15 14 14 CD cord-005453-4057qib7 10152 16 cases case NNS cord-005453-4057qib7 10152 17 ( ( -LRB- cord-005453-4057qib7 10152 18 6,3 6,3 CD cord-005453-4057qib7 10152 19 % % NN cord-005453-4057qib7 10152 20 ) ) -RRB- cord-005453-4057qib7 10152 21 . . . cord-005453-4057qib7 10153 1 Median median JJ cord-005453-4057qib7 10153 2 follow follow NN cord-005453-4057qib7 10153 3 - - HYPH cord-005453-4057qib7 10153 4 up up NN cord-005453-4057qib7 10153 5 was be VBD cord-005453-4057qib7 10153 6 23 23 CD cord-005453-4057qib7 10153 7 months month NNS cord-005453-4057qib7 10154 1 ( ( -LRB- cord-005453-4057qib7 10154 2 range range NN cord-005453-4057qib7 10154 3 : : : cord-005453-4057qib7 10154 4 3 3 CD cord-005453-4057qib7 10154 5 - - SYM cord-005453-4057qib7 10154 6 50 50 CD cord-005453-4057qib7 10154 7 ) ) -RRB- cord-005453-4057qib7 10154 8 . . . cord-005453-4057qib7 10155 1 Patient Patient NNP cord-005453-4057qib7 10155 2 's 's POS cord-005453-4057qib7 10155 3 and and CC cord-005453-4057qib7 10155 4 donor donor NN cord-005453-4057qib7 10155 5 's 's POS cord-005453-4057qib7 10155 6 CMV CMV NNP cord-005453-4057qib7 10155 7 IgG igg NN cord-005453-4057qib7 10155 8 were be VBD cord-005453-4057qib7 10155 9 positive positive JJ cord-005453-4057qib7 10155 10 in in IN cord-005453-4057qib7 10155 11 188 188 CD cord-005453-4057qib7 10155 12 ( ( -LRB- cord-005453-4057qib7 10155 13 82,6 82,6 CD cord-005453-4057qib7 10155 14 % % NN cord-005453-4057qib7 10155 15 ) ) -RRB- cord-005453-4057qib7 10155 16 and and CC cord-005453-4057qib7 10155 17 92 92 CD cord-005453-4057qib7 10155 18 ( ( -LRB- cord-005453-4057qib7 10155 19 58,5 58,5 CD cord-005453-4057qib7 10155 20 % % NN cord-005453-4057qib7 10155 21 ) ) -RRB- cord-005453-4057qib7 10155 22 , , , cord-005453-4057qib7 10155 23 respectively respectively RB cord-005453-4057qib7 10155 24 . . . cord-005453-4057qib7 10156 1 Recipient recipient NN cord-005453-4057qib7 10156 2 / / SYM cord-005453-4057qib7 10156 3 donor donor NN cord-005453-4057qib7 10156 4 serology serology NN cord-005453-4057qib7 10156 5 was be VBD cord-005453-4057qib7 10156 6 + + CD cord-005453-4057qib7 10156 7 /-(risk /-(risk CD cord-005453-4057qib7 10156 8 group group NN cord-005453-4057qib7 10156 9 1 1 CD cord-005453-4057qib7 10156 10 ) ) -RRB- cord-005453-4057qib7 10156 11 in in IN cord-005453-4057qib7 10156 12 62 62 CD cord-005453-4057qib7 10156 13 ( ( -LRB- cord-005453-4057qib7 10156 14 27,7 27,7 CD cord-005453-4057qib7 10156 15 % % NN cord-005453-4057qib7 10156 16 ) ) -RRB- cord-005453-4057qib7 10156 17 , , , cord-005453-4057qib7 10156 18 + + CC cord-005453-4057qib7 10156 19 /+ /+ . cord-005453-4057qib7 10157 1 ( ( -LRB- cord-005453-4057qib7 10157 2 risk risk NN cord-005453-4057qib7 10157 3 group group NN cord-005453-4057qib7 10157 4 2 2 CD cord-005453-4057qib7 10157 5 ) ) -RRB- cord-005453-4057qib7 10157 6 in in IN cord-005453-4057qib7 10157 7 126 126 CD cord-005453-4057qib7 10157 8 ( ( -LRB- cord-005453-4057qib7 10157 9 56,3 56,3 CD cord-005453-4057qib7 10157 10 % % NN cord-005453-4057qib7 10157 11 ) ) -RRB- cord-005453-4057qib7 10157 12 , , . cord-005453-4057qib7 10158 1 -/+ -/+ . cord-005453-4057qib7 10159 1 ( ( -LRB- cord-005453-4057qib7 10159 2 risk risk NN cord-005453-4057qib7 10159 3 group group NN cord-005453-4057qib7 10159 4 3 3 CD cord-005453-4057qib7 10159 5 ) ) -RRB- cord-005453-4057qib7 10159 6 in in IN cord-005453-4057qib7 10159 7 6 6 CD cord-005453-4057qib7 10159 8 ( ( -LRB- cord-005453-4057qib7 10159 9 2,6 2,6 CD cord-005453-4057qib7 10159 10 % % NN cord-005453-4057qib7 10159 11 ) ) -RRB- cord-005453-4057qib7 10160 1 y y NNP cord-005453-4057qib7 10160 2 -/-(risk -/-(risk NNP cord-005453-4057qib7 10160 3 group group NNP cord-005453-4057qib7 10160 4 4 4 CD cord-005453-4057qib7 10160 5 ) ) -RRB- cord-005453-4057qib7 10160 6 in in IN cord-005453-4057qib7 10160 7 30 30 CD cord-005453-4057qib7 10160 8 ( ( -LRB- cord-005453-4057qib7 10160 9 13,4 13,4 CD cord-005453-4057qib7 10160 10 % % NN cord-005453-4057qib7 10160 11 ) ) -RRB- cord-005453-4057qib7 10160 12 . . . cord-005453-4057qib7 10161 1 Results result NNS cord-005453-4057qib7 10161 2 : : : cord-005453-4057qib7 10161 3 two two CD cord-005453-4057qib7 10161 4 pts pt NNS cord-005453-4057qib7 10161 5 underwent undergo VBD cord-005453-4057qib7 10161 6 a a DT cord-005453-4057qib7 10161 7 second second JJ cord-005453-4057qib7 10161 8 transplant transplant NN cord-005453-4057qib7 10161 9 before before IN cord-005453-4057qib7 10161 10 day day NN cord-005453-4057qib7 10161 11 +100 +100 NNS cord-005453-4057qib7 10161 12 due due IN cord-005453-4057qib7 10161 13 to to IN cord-005453-4057qib7 10161 14 graft graft NN cord-005453-4057qib7 10161 15 failure failure NN cord-005453-4057qib7 10161 16 . . . cord-005453-4057qib7 10162 1 Overall overall JJ cord-005453-4057qib7 10162 2 mortalities mortality NNS cord-005453-4057qib7 10162 3 ( ( -LRB- cord-005453-4057qib7 10162 4 OM OM NNP cord-005453-4057qib7 10162 5 ) ) -RRB- cord-005453-4057qib7 10162 6 at at IN cord-005453-4057qib7 10162 7 days day NNS cord-005453-4057qib7 10162 8 +100 +100 NNP cord-005453-4057qib7 10162 9 and and CC cord-005453-4057qib7 10162 10 +365 +365 NNP cord-005453-4057qib7 10162 11 of of IN cord-005453-4057qib7 10162 12 the the DT cord-005453-4057qib7 10162 13 rest rest NN cord-005453-4057qib7 10162 14 of of IN cord-005453-4057qib7 10162 15 the the DT cord-005453-4057qib7 10162 16 series series NN cord-005453-4057qib7 10162 17 ( ( -LRB- cord-005453-4057qib7 10162 18 222 222 CD cord-005453-4057qib7 10162 19 pts pt NNS cord-005453-4057qib7 10162 20 ) ) -RRB- cord-005453-4057qib7 10162 21 are be VBP cord-005453-4057qib7 10162 22 shown show VBN cord-005453-4057qib7 10162 23 in in IN cord-005453-4057qib7 10162 24 table table NN cord-005453-4057qib7 10162 25 . . . cord-005453-4057qib7 10163 1 The the DT cord-005453-4057qib7 10163 2 highest high JJS cord-005453-4057qib7 10163 3 risk risk NN cord-005453-4057qib7 10163 4 group group NN cord-005453-4057qib7 10163 5 ( ( -LRB- cord-005453-4057qib7 10163 6 recipient recipient NN cord-005453-4057qib7 10163 7 CMV CMV NNP cord-005453-4057qib7 10163 8 + + CC cord-005453-4057qib7 10164 1 / / SYM cord-005453-4057qib7 10164 2 donor donor NN cord-005453-4057qib7 10164 3 CMV CMV NNP cord-005453-4057qib7 10164 4 - - , cord-005453-4057qib7 10164 5 ) ) -RRB- cord-005453-4057qib7 10164 6 exhibited exhibit VBD cord-005453-4057qib7 10164 7 more more RBR cord-005453-4057qib7 10164 8 than than IN cord-005453-4057qib7 10164 9 double double JJ cord-005453-4057qib7 10164 10 OM om NN cord-005453-4057qib7 10164 11 at at IN cord-005453-4057qib7 10164 12 day day NN cord-005453-4057qib7 10164 13 +100 +100 NNS cord-005453-4057qib7 10164 14 and and CC cord-005453-4057qib7 10164 15 more more JJR cord-005453-4057qib7 10164 16 than than IN cord-005453-4057qib7 10164 17 four four CD cord-005453-4057qib7 10164 18 times time NNS cord-005453-4057qib7 10164 19 OM OM NNP cord-005453-4057qib7 10164 20 at at IN cord-005453-4057qib7 10164 21 day day NN cord-005453-4057qib7 10164 22 +365 +365 NNP cord-005453-4057qib7 10164 23 , , , cord-005453-4057qib7 10164 24 when when WRB cord-005453-4057qib7 10164 25 compared compare VBN cord-005453-4057qib7 10164 26 with with IN cord-005453-4057qib7 10164 27 pts pt NNS cord-005453-4057qib7 10164 28 at at IN cord-005453-4057qib7 10164 29 lowest low JJS cord-005453-4057qib7 10164 30 risk risk NN cord-005453-4057qib7 10164 31 ( ( -LRB- cord-005453-4057qib7 10164 32 recipient recipient NN cord-005453-4057qib7 10164 33 CMV CMV NNP cord-005453-4057qib7 10164 34 - - , cord-005453-4057qib7 10164 35 ) ) -RRB- cord-005453-4057qib7 10164 36 . . . cord-005453-4057qib7 10165 1 Those those DT cord-005453-4057qib7 10165 2 striking striking JJ cord-005453-4057qib7 10165 3 differences difference NNS cord-005453-4057qib7 10165 4 were be VBD cord-005453-4057qib7 10165 5 mainly mainly RB cord-005453-4057qib7 10165 6 due due JJ cord-005453-4057qib7 10165 7 to to IN cord-005453-4057qib7 10165 8 NRM NRM NNP cord-005453-4057qib7 10165 9 . . . cord-005453-4057qib7 10166 1 OM OM NNP cord-005453-4057qib7 10166 2 for for IN cord-005453-4057qib7 10166 3 risk risk NN cord-005453-4057qib7 10166 4 group group NN cord-005453-4057qib7 10166 5 II II NNP cord-005453-4057qib7 10167 1 ( ( -LRB- cord-005453-4057qib7 10167 2 recipient recipient NN cord-005453-4057qib7 10167 3 CMV CMV NNP cord-005453-4057qib7 10167 4 + + CC cord-005453-4057qib7 10167 5 / / SYM cord-005453-4057qib7 10167 6 donor donor NN cord-005453-4057qib7 10167 7 CMV CMV NNP cord-005453-4057qib7 10167 8 + + CC cord-005453-4057qib7 10167 9 ) ) -RRB- cord-005453-4057qib7 10167 10 was be VBD cord-005453-4057qib7 10167 11 intermediate intermediate JJ cord-005453-4057qib7 10167 12 . . . cord-005453-4057qib7 10168 1 Conclusions conclusion NNS cord-005453-4057qib7 10168 2 : : : cord-005453-4057qib7 10168 3 in in IN cord-005453-4057qib7 10168 4 our -PRON- PRP$ cord-005453-4057qib7 10168 5 studied study VBN cord-005453-4057qib7 10168 6 population population NN cord-005453-4057qib7 10168 7 , , , cord-005453-4057qib7 10168 8 mainly mainly RB cord-005453-4057qib7 10168 9 adult adult NN cord-005453-4057qib7 10168 10 patients patient NNS cord-005453-4057qib7 10168 11 , , , cord-005453-4057qib7 10168 12 the the DT cord-005453-4057qib7 10168 13 combination combination NN cord-005453-4057qib7 10168 14 of of IN cord-005453-4057qib7 10168 15 CMV CMV NNP cord-005453-4057qib7 10168 16 - - HYPH cord-005453-4057qib7 10168 17 seropositive seropositive JJ cord-005453-4057qib7 10168 18 patient patient NN cord-005453-4057qib7 10168 19 with with IN cord-005453-4057qib7 10168 20 a a DT cord-005453-4057qib7 10168 21 CMV CMV NNP cord-005453-4057qib7 10168 22 - - HYPH cord-005453-4057qib7 10168 23 seronegative seronegative JJ cord-005453-4057qib7 10168 24 donor donor NN cord-005453-4057qib7 10168 25 had have VBD cord-005453-4057qib7 10168 26 a a DT cord-005453-4057qib7 10168 27 very very RB cord-005453-4057qib7 10168 28 clear clear JJ cord-005453-4057qib7 10168 29 adverse adverse JJ cord-005453-4057qib7 10168 30 impact impact NN cord-005453-4057qib7 10168 31 on on IN cord-005453-4057qib7 10168 32 HSCT HSCT NNP cord-005453-4057qib7 10168 33 outcome outcome NN cord-005453-4057qib7 10168 34 . . . cord-005453-4057qib7 10169 1 As as IN cord-005453-4057qib7 10169 2 a a DT cord-005453-4057qib7 10169 3 result result NN cord-005453-4057qib7 10169 4 , , , cord-005453-4057qib7 10169 5 we -PRON- PRP cord-005453-4057qib7 10169 6 considered consider VBD cord-005453-4057qib7 10169 7 that that IN cord-005453-4057qib7 10169 8 the the DT cord-005453-4057qib7 10169 9 election election NN cord-005453-4057qib7 10169 10 of of IN cord-005453-4057qib7 10169 11 a a DT cord-005453-4057qib7 10169 12 CMV CMV NNP cord-005453-4057qib7 10169 13 - - HYPH cord-005453-4057qib7 10169 14 positive positive JJ cord-005453-4057qib7 10169 15 donor donor NN cord-005453-4057qib7 10169 16 for for IN cord-005453-4057qib7 10169 17 a a DT cord-005453-4057qib7 10169 18 CMV CMV NNP cord-005453-4057qib7 10169 19 - - HYPH cord-005453-4057qib7 10169 20 positive positive JJ cord-005453-4057qib7 10169 21 patient patient NN cord-005453-4057qib7 10169 22 continues continue VBZ cord-005453-4057qib7 10169 23 to to TO cord-005453-4057qib7 10169 24 be be VB cord-005453-4057qib7 10169 25 strongly strongly RB cord-005453-4057qib7 10169 26 advisable advisable JJ cord-005453-4057qib7 10169 27 , , , cord-005453-4057qib7 10169 28 whenever whenever WRB cord-005453-4057qib7 10169 29 is be VBZ cord-005453-4057qib7 10169 30 possible possible JJ cord-005453-4057qib7 10169 31 . . . cord-005453-4057qib7 10170 1 On on IN cord-005453-4057qib7 10170 2 the the DT cord-005453-4057qib7 10170 3 other other JJ cord-005453-4057qib7 10170 4 hand hand NN cord-005453-4057qib7 10170 5 , , , cord-005453-4057qib7 10170 6 once once IN cord-005453-4057qib7 10170 7 Letermovir Letermovir NNP cord-005453-4057qib7 10170 8 has have VBZ cord-005453-4057qib7 10170 9 proved prove VBN cord-005453-4057qib7 10170 10 to to TO cord-005453-4057qib7 10170 11 be be VB cord-005453-4057qib7 10170 12 efficient efficient JJ cord-005453-4057qib7 10170 13 and and CC cord-005453-4057qib7 10170 14 well well RB cord-005453-4057qib7 10170 15 - - HYPH cord-005453-4057qib7 10170 16 tolerated tolerate VBN cord-005453-4057qib7 10170 17 and and CC cord-005453-4057qib7 10170 18 has have VBZ cord-005453-4057qib7 10170 19 been be VBN cord-005453-4057qib7 10170 20 licensed license VBN cord-005453-4057qib7 10170 21 for for IN cord-005453-4057qib7 10170 22 prophylaxis prophylaxis NN cord-005453-4057qib7 10170 23 of of IN cord-005453-4057qib7 10170 24 CMV CMV NNP cord-005453-4057qib7 10170 25 in in IN cord-005453-4057qib7 10170 26 high high JJ cord-005453-4057qib7 10170 27 risk risk NN cord-005453-4057qib7 10170 28 recipients recipient NNS cord-005453-4057qib7 10170 29 , , , cord-005453-4057qib7 10170 30 this this DT cord-005453-4057qib7 10170 31 approach approach NN cord-005453-4057qib7 10170 32 appears appear VBZ cord-005453-4057qib7 10170 33 to to TO cord-005453-4057qib7 10170 34 be be VB cord-005453-4057qib7 10170 35 very very RB cord-005453-4057qib7 10170 36 attractive attractive JJ cord-005453-4057qib7 10170 37 to to TO cord-005453-4057qib7 10170 38 try try VB cord-005453-4057qib7 10170 39 to to TO cord-005453-4057qib7 10170 40 avoid avoid VB cord-005453-4057qib7 10170 41 the the DT cord-005453-4057qib7 10170 42 adverse adverse JJ cord-005453-4057qib7 10170 43 impact impact NN cord-005453-4057qib7 10170 44 of of IN cord-005453-4057qib7 10170 45 recipient recipient NN cord-005453-4057qib7 10170 46 CMV CMV NNP cord-005453-4057qib7 10170 47 - - HYPH cord-005453-4057qib7 10170 48 seropositivity seropositivity NN cord-005453-4057qib7 10170 49 , , , cord-005453-4057qib7 10170 50 particularly particularly RB cord-005453-4057qib7 10170 51 when when WRB cord-005453-4057qib7 10170 52 finally finally RB cord-005453-4057qib7 10170 53 chosen choose VBN cord-005453-4057qib7 10170 54 donor donor NN cord-005453-4057qib7 10170 55 is be VBZ cord-005453-4057qib7 10170 56 CMV CMV NNP cord-005453-4057qib7 10170 57 negative negative JJ cord-005453-4057qib7 10170 58 . . . cord-005453-4057qib7 10171 1 Disclosure disclosure NN cord-005453-4057qib7 10171 2 : : : cord-005453-4057qib7 10171 3 Nothing nothing NN cord-005453-4057qib7 10171 4 to to TO cord-005453-4057qib7 10171 5 declare declare VB cord-005453-4057qib7 10171 6 An an DT cord-005453-4057qib7 10171 7 active active JJ cord-005453-4057qib7 10171 8 surveillance surveillance NN cord-005453-4057qib7 10171 9 and and CC cord-005453-4057qib7 10171 10 an an DT cord-005453-4057qib7 10171 11 early early JJ cord-005453-4057qib7 10171 12 and and CC cord-005453-4057qib7 10171 13 individualized individualized JJ cord-005453-4057qib7 10171 14 management management NN cord-005453-4057qib7 10171 15 is be VBZ cord-005453-4057qib7 10171 16 critical critical JJ cord-005453-4057qib7 10171 17 to to TO cord-005453-4057qib7 10171 18 avoid avoid VB cord-005453-4057qib7 10171 19 mortality mortality NN cord-005453-4057qib7 10171 20 from from IN cord-005453-4057qib7 10171 21 respiratory respiratory JJ cord-005453-4057qib7 10171 22 viral viral JJ cord-005453-4057qib7 10171 23 infections infection NNS cord-005453-4057qib7 10171 24 in in IN cord-005453-4057qib7 10171 25 allo allo NN cord-005453-4057qib7 10171 26 - - HYPH cord-005453-4057qib7 10171 27 HSCT HSCT NNP cord-005453-4057qib7 10171 28 recipients recipient NNS cord-005453-4057qib7 10171 29 Background Background NNP cord-005453-4057qib7 10171 30 : : : cord-005453-4057qib7 10171 31 Respiratory respiratory JJ cord-005453-4057qib7 10171 32 viral viral JJ cord-005453-4057qib7 10171 33 infections infection NNS cord-005453-4057qib7 10171 34 ( ( -LRB- cord-005453-4057qib7 10171 35 RVIs rvi NNS cord-005453-4057qib7 10171 36 ) ) -RRB- cord-005453-4057qib7 10171 37 are be VBP cord-005453-4057qib7 10171 38 frequent frequent JJ cord-005453-4057qib7 10171 39 among among IN cord-005453-4057qib7 10171 40 the the DT cord-005453-4057qib7 10171 41 general general JJ cord-005453-4057qib7 10171 42 population population NN cord-005453-4057qib7 10171 43 . . . cord-005453-4057qib7 10172 1 In in IN cord-005453-4057qib7 10172 2 transplant transplant NN cord-005453-4057qib7 10172 3 recipients recipient NNS cord-005453-4057qib7 10172 4 , , , cord-005453-4057qib7 10172 5 RVIs rvi NNS cord-005453-4057qib7 10172 6 are be VBP cord-005453-4057qib7 10172 7 known know VBN cord-005453-4057qib7 10172 8 to to TO cord-005453-4057qib7 10172 9 cause cause VB cord-005453-4057qib7 10172 10 an an DT cord-005453-4057qib7 10172 11 important important JJ cord-005453-4057qib7 10172 12 morbidity morbidity NN cord-005453-4057qib7 10172 13 and and CC cord-005453-4057qib7 10172 14 potential potential JJ cord-005453-4057qib7 10172 15 mortality mortality NN cord-005453-4057qib7 10172 16 . . . cord-005453-4057qib7 10173 1 For for IN cord-005453-4057qib7 10173 2 this this DT cord-005453-4057qib7 10173 3 reason reason NN cord-005453-4057qib7 10173 4 and and CC cord-005453-4057qib7 10173 5 several several JJ cord-005453-4057qib7 10173 6 others other NNS cord-005453-4057qib7 10173 7 , , , cord-005453-4057qib7 10173 8 as as IN cord-005453-4057qib7 10173 9 the the DT cord-005453-4057qib7 10173 10 need need NN cord-005453-4057qib7 10173 11 of of IN cord-005453-4057qib7 10173 12 preventing prevent VBG cord-005453-4057qib7 10173 13 other other JJ cord-005453-4057qib7 10173 14 pts pt NNS cord-005453-4057qib7 10173 15 from from IN cord-005453-4057qib7 10173 16 contagious contagious JJ cord-005453-4057qib7 10173 17 or or CC cord-005453-4057qib7 10173 18 avoiding avoid VBG cord-005453-4057qib7 10173 19 misdiagnosis misdiagnosis NN cord-005453-4057qib7 10173 20 with with IN cord-005453-4057qib7 10173 21 other other JJ cord-005453-4057qib7 10173 22 infections infection NNS cord-005453-4057qib7 10173 23 processes process NNS cord-005453-4057qib7 10173 24 , , , cord-005453-4057qib7 10173 25 a a DT cord-005453-4057qib7 10173 26 high high JJ cord-005453-4057qib7 10173 27 index index NN cord-005453-4057qib7 10173 28 of of IN cord-005453-4057qib7 10173 29 suspicion suspicion NN cord-005453-4057qib7 10173 30 of of IN cord-005453-4057qib7 10173 31 VRIs vris NN cord-005453-4057qib7 10173 32 is be VBZ cord-005453-4057qib7 10173 33 necessary necessary JJ cord-005453-4057qib7 10173 34 . . . cord-005453-4057qib7 10174 1 During during IN cord-005453-4057qib7 10174 2 the the DT cord-005453-4057qib7 10174 3 last last JJ cord-005453-4057qib7 10174 4 few few JJ cord-005453-4057qib7 10174 5 years year NNS cord-005453-4057qib7 10174 6 , , , cord-005453-4057qib7 10174 7 we -PRON- PRP cord-005453-4057qib7 10174 8 have have VBP cord-005453-4057qib7 10174 9 implemented implement VBN cord-005453-4057qib7 10174 10 an an DT cord-005453-4057qib7 10174 11 active active JJ cord-005453-4057qib7 10174 12 and and CC cord-005453-4057qib7 10174 13 systematic systematic JJ cord-005453-4057qib7 10174 14 surveillance surveillance NN cord-005453-4057qib7 10174 15 policy policy NN cord-005453-4057qib7 10174 16 orientedto orientedto NN cord-005453-4057qib7 10174 17 early early JJ cord-005453-4057qib7 10174 18 detection detection NN cord-005453-4057qib7 10174 19 and and CC cord-005453-4057qib7 10174 20 management management NN cord-005453-4057qib7 10174 21 of of IN cord-005453-4057qib7 10174 22 RVIs rvi NNS cord-005453-4057qib7 10174 23 in in IN cord-005453-4057qib7 10174 24 the the DT cord-005453-4057qib7 10174 25 HSCT HSCT NNP cord-005453-4057qib7 10174 26 recipients recipient NNS cord-005453-4057qib7 10174 27 . . . cord-005453-4057qib7 10175 1 Methods method NNS cord-005453-4057qib7 10175 2 : : : cord-005453-4057qib7 10176 1 The the DT cord-005453-4057qib7 10176 2 population population NN cord-005453-4057qib7 10176 3 analyzed analyze VBD cord-005453-4057qib7 10176 4 for for IN cord-005453-4057qib7 10176 5 this this DT cord-005453-4057qib7 10176 6 report report NN cord-005453-4057qib7 10176 7 is be VBZ cord-005453-4057qib7 10176 8 the the DT cord-005453-4057qib7 10176 9 175 175 CD cord-005453-4057qib7 10176 10 patients patient NNS cord-005453-4057qib7 10176 11 who who WP cord-005453-4057qib7 10176 12 underwent undergo VBD cord-005453-4057qib7 10176 13 allo allo NN cord-005453-4057qib7 10176 14 - - HYPH cord-005453-4057qib7 10176 15 HSCT HSCT NNP cord-005453-4057qib7 10176 16 from from IN cord-005453-4057qib7 10176 17 January January NNP cord-005453-4057qib7 10176 18 2015 2015 CD cord-005453-4057qib7 10176 19 through through IN cord-005453-4057qib7 10176 20 March March NNP cord-005453-4057qib7 10176 21 2018 2018 CD cord-005453-4057qib7 10176 22 in in IN cord-005453-4057qib7 10176 23 our -PRON- PRP$ cord-005453-4057qib7 10176 24 Unit unit NN cord-005453-4057qib7 10176 25 . . . cord-005453-4057qib7 10177 1 Median median JJ cord-005453-4057qib7 10177 2 age age NN cord-005453-4057qib7 10177 3 at at IN cord-005453-4057qib7 10177 4 transplant transplant NN cord-005453-4057qib7 10177 5 was be VBD cord-005453-4057qib7 10177 6 51 51 CD cord-005453-4057qib7 10177 7 years year NNS cord-005453-4057qib7 10178 1 ( ( -LRB- cord-005453-4057qib7 10178 2 range range NN cord-005453-4057qib7 10178 3 : : : cord-005453-4057qib7 10178 4 7 7 CD cord-005453-4057qib7 10178 5 - - SYM cord-005453-4057qib7 10178 6 69 69 CD cord-005453-4057qib7 10178 7 ) ) -RRB- cord-005453-4057qib7 10178 8 . . . cord-005453-4057qib7 10179 1 One one CD cord-005453-4057qib7 10179 2 hundred hundred CD cord-005453-4057qib7 10179 3 and and CC cord-005453-4057qib7 10179 4 four four CD cord-005453-4057qib7 10179 5 were be VBD cord-005453-4057qib7 10179 6 male male JJ cord-005453-4057qib7 10179 7 ( ( -LRB- cord-005453-4057qib7 10179 8 59.4 59.4 CD cord-005453-4057qib7 10179 9 % % NN cord-005453-4057qib7 10179 10 ) ) -RRB- cord-005453-4057qib7 10179 11 and and CC cord-005453-4057qib7 10179 12 71 71 CD cord-005453-4057qib7 10179 13 were be VBD cord-005453-4057qib7 10179 14 female female JJ cord-005453-4057qib7 10179 15 ( ( -LRB- cord-005453-4057qib7 10179 16 40,6 40,6 CD cord-005453-4057qib7 10179 17 % % NN cord-005453-4057qib7 10179 18 ) ) -RRB- cord-005453-4057qib7 10179 19 . . . cord-005453-4057qib7 10180 1 Baseline baseline JJ cord-005453-4057qib7 10180 2 diseases disease NNS cord-005453-4057qib7 10180 3 were be VBD cord-005453-4057qib7 10180 4 : : : cord-005453-4057qib7 10180 5 64 64 CD cord-005453-4057qib7 10180 6 AML AML NNP cord-005453-4057qib7 10180 7 , , , cord-005453-4057qib7 10180 8 38 38 CD cord-005453-4057qib7 10180 9 LPD LPD NNP cord-005453-4057qib7 10180 10 , , , cord-005453-4057qib7 10180 11 23 23 CD cord-005453-4057qib7 10180 12 ALL all DT cord-005453-4057qib7 10180 13 , , , cord-005453-4057qib7 10180 14 19 19 CD cord-005453-4057qib7 10180 15 MDS MDS NNP cord-005453-4057qib7 10180 16 , , , cord-005453-4057qib7 10180 17 15 15 CD cord-005453-4057qib7 10180 18 MPD MPD NNP cord-005453-4057qib7 10180 19 , , , cord-005453-4057qib7 10180 20 10 10 CD cord-005453-4057qib7 10180 21 MM mm NN cord-005453-4057qib7 10180 22 , , , cord-005453-4057qib7 10180 23 and and CC cord-005453-4057qib7 10180 24 6 6 CD cord-005453-4057qib7 10180 25 BMF bmf NN cord-005453-4057qib7 10180 26 . . . cord-005453-4057qib7 10181 1 Donor donor NN cord-005453-4057qib7 10181 2 was be VBD cord-005453-4057qib7 10181 3 unrelated unrelated JJ cord-005453-4057qib7 10181 4 in in IN cord-005453-4057qib7 10181 5 92 92 CD cord-005453-4057qib7 10181 6 transplants transplant NNS cord-005453-4057qib7 10181 7 ( ( -LRB- cord-005453-4057qib7 10181 8 52.6 52.6 CD cord-005453-4057qib7 10181 9 % % NN cord-005453-4057qib7 10181 10 ) ) -RRB- cord-005453-4057qib7 10181 11 and and CC cord-005453-4057qib7 10181 12 was be VBD cord-005453-4057qib7 10181 13 family family NN cord-005453-4057qib7 10181 14 in in IN cord-005453-4057qib7 10181 15 83 83 CD cord-005453-4057qib7 10181 16 ( ( -LRB- cord-005453-4057qib7 10181 17 47.4 47.4 CD cord-005453-4057qib7 10181 18 % % NN cord-005453-4057qib7 10181 19 ) ) -RRB- cord-005453-4057qib7 10181 20 ( ( -LRB- cord-005453-4057qib7 10181 21 including include VBG cord-005453-4057qib7 10181 22 29 29 CD cord-005453-4057qib7 10181 23 haplo haplo NN cord-005453-4057qib7 10181 24 - - HYPH cord-005453-4057qib7 10181 25 identical identical JJ cord-005453-4057qib7 10181 26 ) ) -RRB- cord-005453-4057qib7 10181 27 . . . cord-005453-4057qib7 10182 1 Conditioning conditioning NN cord-005453-4057qib7 10182 2 regimen regimen NN cord-005453-4057qib7 10182 3 was be VBD cord-005453-4057qib7 10182 4 reduced reduce VBN cord-005453-4057qib7 10182 5 in in IN cord-005453-4057qib7 10182 6 91 91 CD cord-005453-4057qib7 10182 7 procedures procedure NNS cord-005453-4057qib7 10182 8 ( ( -LRB- cord-005453-4057qib7 10182 9 52 52 CD cord-005453-4057qib7 10182 10 % % NN cord-005453-4057qib7 10182 11 ) ) -RRB- cord-005453-4057qib7 10182 12 and and CC cord-005453-4057qib7 10182 13 intensive intensive JJ cord-005453-4057qib7 10182 14 in in IN cord-005453-4057qib7 10182 15 84 84 CD cord-005453-4057qib7 10182 16 ( ( -LRB- cord-005453-4057qib7 10182 17 48%).Stem 48%).stem CD cord-005453-4057qib7 10182 18 cell cell NN cord-005453-4057qib7 10182 19 source source NN cord-005453-4057qib7 10182 20 was be VBD cord-005453-4057qib7 10182 21 PB PB NNP cord-005453-4057qib7 10182 22 in in IN cord-005453-4057qib7 10182 23 163 163 CD cord-005453-4057qib7 10182 24 ( ( -LRB- cord-005453-4057qib7 10182 25 93.1 93.1 CD cord-005453-4057qib7 10182 26 % % NN cord-005453-4057qib7 10182 27 ) ) -RRB- cord-005453-4057qib7 10182 28 and and CC cord-005453-4057qib7 10182 29 BM BM NNP cord-005453-4057qib7 10182 30 in in IN cord-005453-4057qib7 10182 31 12 12 CD cord-005453-4057qib7 10182 32 pts pt NNS cord-005453-4057qib7 10182 33 ( ( -LRB- cord-005453-4057qib7 10182 34 6.9%).Median 6.9%).median CD cord-005453-4057qib7 10182 35 follow follow NN cord-005453-4057qib7 10182 36 - - HYPH cord-005453-4057qib7 10182 37 up up NN cord-005453-4057qib7 10182 38 was be VBD cord-005453-4057qib7 10182 39 27 27 CD cord-005453-4057qib7 10182 40 months month NNS cord-005453-4057qib7 10183 1 ( ( -LRB- cord-005453-4057qib7 10183 2 range range NN cord-005453-4057qib7 10183 3 : : : cord-005453-4057qib7 10183 4 8 8 CD cord-005453-4057qib7 10183 5 - - SYM cord-005453-4057qib7 10183 6 46 46 CD cord-005453-4057qib7 10183 7 ) ) -RRB- cord-005453-4057qib7 10183 8 ; ; : cord-005453-4057qib7 10183 9 at at IN cord-005453-4057qib7 10183 10 the the DT cord-005453-4057qib7 10183 11 close close NN cord-005453-4057qib7 10183 12 of of IN cord-005453-4057qib7 10183 13 the the DT cord-005453-4057qib7 10183 14 analysis analysis NN cord-005453-4057qib7 10183 15 , , , cord-005453-4057qib7 10183 16 majority majority NN cord-005453-4057qib7 10183 17 of of IN cord-005453-4057qib7 10183 18 the the DT cord-005453-4057qib7 10183 19 series series NN cord-005453-4057qib7 10183 20 ( ( -LRB- cord-005453-4057qib7 10183 21 89.1 89.1 CD cord-005453-4057qib7 10183 22 % % NN cord-005453-4057qib7 10183 23 ) ) -RRB- cord-005453-4057qib7 10183 24 had have VBD cord-005453-4057qib7 10183 25 a a DT cord-005453-4057qib7 10183 26 follow follow NN cord-005453-4057qib7 10183 27 - - HYPH cord-005453-4057qib7 10183 28 up up NN cord-005453-4057qib7 10183 29 superior superior JJ cord-005453-4057qib7 10183 30 to to IN cord-005453-4057qib7 10183 31 one one CD cord-005453-4057qib7 10183 32 year year NN cord-005453-4057qib7 10183 33 from from IN cord-005453-4057qib7 10183 34 HSCT HSCT NNP cord-005453-4057qib7 10183 35 . . . cord-005453-4057qib7 10184 1 A a DT cord-005453-4057qib7 10184 2 throat throat NN cord-005453-4057qib7 10184 3 swab(TS swab(ts NN cord-005453-4057qib7 10184 4 ) ) -RRB- cord-005453-4057qib7 10184 5 was be VBD cord-005453-4057qib7 10184 6 taken take VBN cord-005453-4057qib7 10184 7 from from IN cord-005453-4057qib7 10184 8 every every DT cord-005453-4057qib7 10184 9 patient patient NN cord-005453-4057qib7 10184 10 with with IN cord-005453-4057qib7 10184 11 any any DT cord-005453-4057qib7 10184 12 , , , cord-005453-4057qib7 10184 13 even even RB cord-005453-4057qib7 10184 14 minor minor JJ cord-005453-4057qib7 10184 15 , , , cord-005453-4057qib7 10184 16 respiratory respiratory JJ cord-005453-4057qib7 10184 17 symptoms symptom NNS cord-005453-4057qib7 10184 18 . . . cord-005453-4057qib7 10185 1 The the DT cord-005453-4057qib7 10185 2 respiratorysamples respiratorysample NNS cord-005453-4057qib7 10185 3 were be VBD cord-005453-4057qib7 10185 4 tested test VBN cord-005453-4057qib7 10185 5 whith whith IN cord-005453-4057qib7 10185 6 a a DT cord-005453-4057qib7 10185 7 complete complete JJ cord-005453-4057qib7 10185 8 PCR PCR NNP cord-005453-4057qib7 10185 9 panel panel NN cord-005453-4057qib7 10185 10 of of IN cord-005453-4057qib7 10185 11 human human JJ cord-005453-4057qib7 10185 12 respiratory respiratory JJ cord-005453-4057qib7 10185 13 viruses virus NNS cord-005453-4057qib7 10185 14 : : : cord-005453-4057qib7 10185 15 rhinovirus rhinovirus NN cord-005453-4057qib7 10185 16 ( ( -LRB- cord-005453-4057qib7 10185 17 RV RV NNP cord-005453-4057qib7 10185 18 ) ) -RRB- cord-005453-4057qib7 10185 19 , , , cord-005453-4057qib7 10185 20 influenza influenza NN cord-005453-4057qib7 10185 21 A a NN cord-005453-4057qib7 10185 22 and and CC cord-005453-4057qib7 10185 23 B B NNP cord-005453-4057qib7 10185 24 virus virus NN cord-005453-4057qib7 10185 25 ( ( -LRB- cord-005453-4057qib7 10185 26 IV IV NNP cord-005453-4057qib7 10185 27 - - HYPH cord-005453-4057qib7 10185 28 A A NNP cord-005453-4057qib7 10185 29 , , , cord-005453-4057qib7 10185 30 IV IV NNP cord-005453-4057qib7 10185 31 - - HYPH cord-005453-4057qib7 10185 32 B B NNP cord-005453-4057qib7 10185 33 ) ) -RRB- cord-005453-4057qib7 10185 34 , , , cord-005453-4057qib7 10185 35 parainfluenza parainfluenza NNP cord-005453-4057qib7 10185 36 virus virus NNP cord-005453-4057qib7 10185 37 ( ( -LRB- cord-005453-4057qib7 10185 38 PIVs piv NNS cord-005453-4057qib7 10185 39 1 1 CD cord-005453-4057qib7 10185 40 - - SYM cord-005453-4057qib7 10185 41 4 4 CD cord-005453-4057qib7 10185 42 ) ) -RRB- cord-005453-4057qib7 10185 43 , , , cord-005453-4057qib7 10185 44 respiratory respiratory JJ cord-005453-4057qib7 10185 45 syncytial syncytial JJ cord-005453-4057qib7 10185 46 virus virus NN cord-005453-4057qib7 10185 47 ( ( -LRB- cord-005453-4057qib7 10185 48 RSV RSV NNP cord-005453-4057qib7 10185 49 ) ) -RRB- cord-005453-4057qib7 10185 50 , , , cord-005453-4057qib7 10185 51 metapneumovirus metapneumovirus NNP cord-005453-4057qib7 10185 52 ( ( -LRB- cord-005453-4057qib7 10185 53 MPV MPV NNP cord-005453-4057qib7 10185 54 ) ) -RRB- cord-005453-4057qib7 10185 55 , , , cord-005453-4057qib7 10185 56 coronavirus coronavirus NN cord-005453-4057qib7 10185 57 ( ( -LRB- cord-005453-4057qib7 10185 58 CoV CoV NNP cord-005453-4057qib7 10185 59 ) ) -RRB- cord-005453-4057qib7 10185 60 , , , cord-005453-4057qib7 10185 61 adenovirus adenovirus NN cord-005453-4057qib7 10185 62 ( ( -LRB- cord-005453-4057qib7 10185 63 AdV AdV NNP cord-005453-4057qib7 10185 64 ) ) -RRB- cord-005453-4057qib7 10185 65 , , , cord-005453-4057qib7 10185 66 and and CC cord-005453-4057qib7 10185 67 bocavirus bocavirus NNP cord-005453-4057qib7 10185 68 ( ( -LRB- cord-005453-4057qib7 10185 69 BoV BoV NNP cord-005453-4057qib7 10185 70 ) ) -RRB- cord-005453-4057qib7 10185 71 . . . cord-005453-4057qib7 10186 1 Results result NNS cord-005453-4057qib7 10186 2 : : : cord-005453-4057qib7 10187 1 Day day NN cord-005453-4057qib7 10187 2 +100 +100 . cord-005453-4057qib7 10188 1 overall overall JJ cord-005453-4057qib7 10188 2 mortality mortality NN cord-005453-4057qib7 10188 3 of of IN cord-005453-4057qib7 10188 4 the the DT cord-005453-4057qib7 10188 5 series series NN cord-005453-4057qib7 10188 6 was be VBD cord-005453-4057qib7 10188 7 8,6 8,6 CD cord-005453-4057qib7 10188 8 % % NN cord-005453-4057qib7 10188 9 . . . cord-005453-4057qib7 10189 1 Day day NN cord-005453-4057qib7 10189 2 +365 +365 NNP cord-005453-4057qib7 10189 3 overall overall JJ cord-005453-4057qib7 10189 4 mortality mortality NN cord-005453-4057qib7 10189 5 was be VBD cord-005453-4057qib7 10189 6 25,1 25,1 CD cord-005453-4057qib7 10189 7 % % NN cord-005453-4057qib7 10189 8 ( ( -LRB- cord-005453-4057qib7 10189 9 13,7 13,7 CD cord-005453-4057qib7 10189 10 % % NN cord-005453-4057qib7 10189 11 nonrelapse nonrelapse JJ cord-005453-4057qib7 10189 12 mortality mortality NN cord-005453-4057qib7 10189 13 -NRM- -NRM- , cord-005453-4057qib7 10189 14 , , , cord-005453-4057qib7 10189 15 and and CC cord-005453-4057qib7 10189 16 11,4 11,4 CD cord-005453-4057qib7 10189 17 % % NN cord-005453-4057qib7 10189 18 progression progression NN cord-005453-4057qib7 10189 19 / / SYM cord-005453-4057qib7 10189 20 relapse relapse NN cord-005453-4057qib7 10189 21 mortality mortality NN cord-005453-4057qib7 10189 22 ) ) -RRB- cord-005453-4057qib7 10189 23 . . . cord-005453-4057qib7 10190 1 Causes cause NNS cord-005453-4057qib7 10190 2 of of IN cord-005453-4057qib7 10190 3 NRM NRM NNP cord-005453-4057qib7 10190 4 reflected reflect VBN cord-005453-4057qib7 10190 5 in in IN cord-005453-4057qib7 10190 6 table table NN cord-005453-4057qib7 10190 7 1 1 CD cord-005453-4057qib7 10190 8 . . . cord-005453-4057qib7 10191 1 No no DT cord-005453-4057qib7 10191 2 patients patient NNS cord-005453-4057qib7 10191 3 died die VBD cord-005453-4057qib7 10191 4 due due IN cord-005453-4057qib7 10191 5 to to IN cord-005453-4057qib7 10191 6 RVIs rvi NNS cord-005453-4057qib7 10191 7 . . . cord-005453-4057qib7 10192 1 From from IN cord-005453-4057qib7 10192 2 1 1 CD cord-005453-4057qib7 10192 3 st st NNP cord-005453-4057qib7 10192 4 July July NNP cord-005453-4057qib7 10192 5 2016 2016 CD cord-005453-4057qib7 10192 6 through through IN cord-005453-4057qib7 10192 7 30 30 CD cord-005453-4057qib7 10192 8 th th DT cord-005453-4057qib7 10192 9 June June NNP cord-005453-4057qib7 10192 10 2018 2018 CD cord-005453-4057qib7 10192 11 ( ( -LRB- cord-005453-4057qib7 10192 12 a a DT cord-005453-4057qib7 10192 13 24-month 24-month JJ cord-005453-4057qib7 10192 14 period period NN cord-005453-4057qib7 10192 15 ) ) -RRB- cord-005453-4057qib7 10192 16 , , , cord-005453-4057qib7 10192 17 581 581 CD cord-005453-4057qib7 10192 18 TS ts NN cord-005453-4057qib7 10192 19 samples sample NNS cord-005453-4057qib7 10192 20 were be VBD cord-005453-4057qib7 10192 21 obtained obtain VBN cord-005453-4057qib7 10192 22 from from IN cord-005453-4057qib7 10192 23 129 129 CD cord-005453-4057qib7 10192 24 pts pt NNS cord-005453-4057qib7 10192 25 ( ( -LRB- cord-005453-4057qib7 10193 1 73,7%).The 73,7%).the CD cord-005453-4057qib7 10193 2 median median JJ cord-005453-4057qib7 10193 3 number number NN cord-005453-4057qib7 10193 4 of of IN cord-005453-4057qib7 10193 5 samples sample NNS cord-005453-4057qib7 10193 6 / / SYM cord-005453-4057qib7 10193 7 patient patient NN cord-005453-4057qib7 10193 8 was be VBD cord-005453-4057qib7 10193 9 3 3 CD cord-005453-4057qib7 10194 1 ( ( -LRB- cord-005453-4057qib7 10194 2 range range NN cord-005453-4057qib7 10194 3 : : : cord-005453-4057qib7 10194 4 1 1 CD cord-005453-4057qib7 10194 5 - - SYM cord-005453-4057qib7 10194 6 17).A 17).a CD cord-005453-4057qib7 10194 7 total total NN cord-005453-4057qib7 10194 8 of of IN cord-005453-4057qib7 10194 9 162 162 CD cord-005453-4057qib7 10195 1 ( ( -LRB- cord-005453-4057qib7 10195 2 1 1 CD cord-005453-4057qib7 10195 3 - - SYM cord-005453-4057qib7 10195 4 8 8 CD cord-005453-4057qib7 10195 5 ) ) -RRB- cord-005453-4057qib7 10195 6 RVIs rvi NNS cord-005453-4057qib7 10195 7 episodes episode NNS cord-005453-4057qib7 10195 8 were be VBD cord-005453-4057qib7 10195 9 diagnosed diagnose VBN cord-005453-4057qib7 10195 10 in in IN cord-005453-4057qib7 10195 11 87 87 CD cord-005453-4057qib7 10195 12 pts pt NNS cord-005453-4057qib7 10195 13 ( ( -LRB- cord-005453-4057qib7 10195 14 49,7%).The 49,7%).the CD cord-005453-4057qib7 10195 15 median median JJ cord-005453-4057qib7 10195 16 presentation presentation NN cord-005453-4057qib7 10195 17 of of IN cord-005453-4057qib7 10195 18 the the DT cord-005453-4057qib7 10195 19 first first JJ cord-005453-4057qib7 10195 20 RVI RVI NNP cord-005453-4057qib7 10195 21 was be VBD cord-005453-4057qib7 10195 22 at at IN cord-005453-4057qib7 10195 23 the the DT cord-005453-4057qib7 10195 24 day day NN cord-005453-4057qib7 10195 25 + + SYM cord-005453-4057qib7 10195 26 226 226 CD cord-005453-4057qib7 10195 27 ( ( -LRB- cord-005453-4057qib7 10195 28 3 3 CD cord-005453-4057qib7 10195 29 - - SYM cord-005453-4057qib7 10195 30 924 924 CD cord-005453-4057qib7 10195 31 ) ) -RRB- cord-005453-4057qib7 10196 1 post post JJ cord-005453-4057qib7 10196 2 - - JJ cord-005453-4057qib7 10196 3 HSCT HSCT NNP cord-005453-4057qib7 10196 4 . . . cord-005453-4057qib7 10197 1 The the DT cord-005453-4057qib7 10197 2 viral viral JJ cord-005453-4057qib7 10197 3 distribution distribution NN cord-005453-4057qib7 10197 4 was be VBD cord-005453-4057qib7 10197 5 : : : cord-005453-4057qib7 10197 6 47 47 CD cord-005453-4057qib7 10197 7 RV RV NNP cord-005453-4057qib7 10197 8 ( ( -LRB- cord-005453-4057qib7 10197 9 26.6 26.6 CD cord-005453-4057qib7 10197 10 % % NN cord-005453-4057qib7 10197 11 ) ) -RRB- cord-005453-4057qib7 10197 12 , , , cord-005453-4057qib7 10197 13 36 36 CD cord-005453-4057qib7 10197 14 IV IV NNP cord-005453-4057qib7 10197 15 ( ( -LRB- cord-005453-4057qib7 10197 16 20.3 20.3 CD cord-005453-4057qib7 10197 17 % % NN cord-005453-4057qib7 10197 18 ) ) -RRB- cord-005453-4057qib7 10197 19 , , , cord-005453-4057qib7 10197 20 33 33 CD cord-005453-4057qib7 10197 21 PIV PIV NNP cord-005453-4057qib7 10197 22 ( ( -LRB- cord-005453-4057qib7 10197 23 18.6 18.6 CD cord-005453-4057qib7 10197 24 % % NN cord-005453-4057qib7 10197 25 ) ) -RRB- cord-005453-4057qib7 10197 26 , , , cord-005453-4057qib7 10197 27 28 28 CD cord-005453-4057qib7 10197 28 RSV RSV NNP cord-005453-4057qib7 10197 29 ( ( -LRB- cord-005453-4057qib7 10197 30 15.8 15.8 CD cord-005453-4057qib7 10197 31 % % NN cord-005453-4057qib7 10197 32 ) ) -RRB- cord-005453-4057qib7 10197 33 , , , cord-005453-4057qib7 10197 34 12 12 CD cord-005453-4057qib7 10197 35 MPV MPV NNP cord-005453-4057qib7 10197 36 ( ( -LRB- cord-005453-4057qib7 10197 37 6.8 6.8 CD cord-005453-4057qib7 10197 38 % % NN cord-005453-4057qib7 10197 39 ) ) -RRB- cord-005453-4057qib7 10197 40 , , , cord-005453-4057qib7 10197 41 11 11 CD cord-005453-4057qib7 10197 42 CoV cov NN cord-005453-4057qib7 10197 43 ( ( -LRB- cord-005453-4057qib7 10197 44 6.2 6.2 CD cord-005453-4057qib7 10197 45 % % NN cord-005453-4057qib7 10197 46 ) ) -RRB- cord-005453-4057qib7 10197 47 , , , cord-005453-4057qib7 10197 48 9 9 CD cord-005453-4057qib7 10197 49 AdV adv NN cord-005453-4057qib7 10197 50 ( ( -LRB- cord-005453-4057qib7 10197 51 5.1 5.1 CD cord-005453-4057qib7 10197 52 % % NN cord-005453-4057qib7 10197 53 ) ) -RRB- cord-005453-4057qib7 10197 54 , , , cord-005453-4057qib7 10197 55 and and CC cord-005453-4057qib7 10197 56 1 1 CD cord-005453-4057qib7 10197 57 BoV bov NN cord-005453-4057qib7 10197 58 ( ( -LRB- cord-005453-4057qib7 10197 59 0.6%).There 0.6%).there CD cord-005453-4057qib7 10197 60 were be VBD cord-005453-4057qib7 10197 61 13 13 CD cord-005453-4057qib7 10197 62 mixed mixed JJ cord-005453-4057qib7 10197 63 ( ( -LRB- cord-005453-4057qib7 10197 64 two two CD cord-005453-4057qib7 10197 65 or or CC cord-005453-4057qib7 10197 66 more more JJR cord-005453-4057qib7 10197 67 viruses virus NNS cord-005453-4057qib7 10197 68 ) ) -RRB- cord-005453-4057qib7 10197 69 RVI RVI NNP cord-005453-4057qib7 10197 70 episodes episode NNS cord-005453-4057qib7 10197 71 . . . cord-005453-4057qib7 10198 1 The the DT cord-005453-4057qib7 10198 2 temporary temporary JJ cord-005453-4057qib7 10198 3 distribution distribution NN cord-005453-4057qib7 10198 4 of of IN cord-005453-4057qib7 10198 5 VRI VRI NNP cord-005453-4057qib7 10198 6 episodes episode NNS cord-005453-4057qib7 10198 7 is be VBZ cord-005453-4057qib7 10198 8 shown show VBN cord-005453-4057qib7 10198 9 in in IN cord-005453-4057qib7 10198 10 figure figure NN cord-005453-4057qib7 10198 11 1 1 CD cord-005453-4057qib7 10198 12 . . . cord-005453-4057qib7 10199 1 Conclusions conclusion NNS cord-005453-4057qib7 10199 2 : : : cord-005453-4057qib7 10200 1 1 1 LS cord-005453-4057qib7 10200 2 ) ) -RRB- cord-005453-4057qib7 10200 3 Symptomatic symptomatic JJ cord-005453-4057qib7 10200 4 infections infection NNS cord-005453-4057qib7 10200 5 due due JJ cord-005453-4057qib7 10200 6 to to IN cord-005453-4057qib7 10200 7 respiratory respiratory JJ cord-005453-4057qib7 10200 8 viruses virus NNS cord-005453-4057qib7 10200 9 are be VBP cord-005453-4057qib7 10200 10 very very RB cord-005453-4057qib7 10200 11 frequent frequent JJ cord-005453-4057qib7 10200 12 among among IN cord-005453-4057qib7 10200 13 the the DT cord-005453-4057qib7 10200 14 allo allo NN cord-005453-4057qib7 10200 15 - - HYPH cord-005453-4057qib7 10200 16 HSCT HSCT NNP cord-005453-4057qib7 10200 17 recipients recipient NNS cord-005453-4057qib7 10200 18 . . . cord-005453-4057qib7 10201 1 2 2 LS cord-005453-4057qib7 10201 2 ) ) -RRB- cord-005453-4057qib7 10202 1 A a DT cord-005453-4057qib7 10202 2 high high JJ cord-005453-4057qib7 10202 3 level level NN cord-005453-4057qib7 10202 4 of of IN cord-005453-4057qib7 10202 5 suspicion suspicion NN cord-005453-4057qib7 10202 6 , , , cord-005453-4057qib7 10202 7 as as RB cord-005453-4057qib7 10202 8 well well RB cord-005453-4057qib7 10202 9 as as IN cord-005453-4057qib7 10202 10 an an DT cord-005453-4057qib7 10202 11 early early JJ cord-005453-4057qib7 10202 12 and and CC cord-005453-4057qib7 10202 13 systematic systematic JJ cord-005453-4057qib7 10202 14 screening screening NN cord-005453-4057qib7 10202 15 and and CC cord-005453-4057qib7 10202 16 management management NN cord-005453-4057qib7 10202 17 policy policy NN cord-005453-4057qib7 10202 18 , , , cord-005453-4057qib7 10202 19 are be VBP cord-005453-4057qib7 10202 20 critical critical JJ cord-005453-4057qib7 10202 21 to to TO cord-005453-4057qib7 10202 22 avoid avoid VB cord-005453-4057qib7 10202 23 potential potential JJ cord-005453-4057qib7 10202 24 attributable attributable JJ cord-005453-4057qib7 10202 25 mortality mortality NN cord-005453-4057qib7 10202 26 and and CC cord-005453-4057qib7 10202 27 the the DT cord-005453-4057qib7 10202 28 nosocomial nosocomial JJ cord-005453-4057qib7 10202 29 spread spread NN cord-005453-4057qib7 10202 30 of of IN cord-005453-4057qib7 10202 31 RVIs rvi NNS cord-005453-4057qib7 10202 32 among among IN cord-005453-4057qib7 10202 33 the the DT cord-005453-4057qib7 10202 34 transplant transplant NN cord-005453-4057qib7 10202 35 recipients recipient NNS cord-005453-4057qib7 10202 36 . . . cord-005453-4057qib7 10203 1 3 3 LS cord-005453-4057qib7 10203 2 ) ) -RRB- cord-005453-4057qib7 10204 1 In in IN cord-005453-4057qib7 10204 2 our -PRON- PRP$ cord-005453-4057qib7 10204 3 series series NN cord-005453-4057qib7 10204 4 , , , cord-005453-4057qib7 10204 5 rhinovirus rhinovirus NN cord-005453-4057qib7 10204 6 , , , cord-005453-4057qib7 10204 7 parainfluenza parainfluenza NNP cord-005453-4057qib7 10204 8 and and CC cord-005453-4057qib7 10204 9 adenovirus adenovirus NN cord-005453-4057qib7 10204 10 might may MD cord-005453-4057qib7 10204 11 be be VB cord-005453-4057qib7 10204 12 detected detect VBN cord-005453-4057qib7 10204 13 at at IN cord-005453-4057qib7 10204 14 any any DT cord-005453-4057qib7 10204 15 moment moment NN cord-005453-4057qib7 10204 16 of of IN cord-005453-4057qib7 10204 17 the the DT cord-005453-4057qib7 10204 18 year year NN cord-005453-4057qib7 10204 19 ; ; : cord-005453-4057qib7 10204 20 the the DT cord-005453-4057qib7 10204 21 rest rest NN cord-005453-4057qib7 10204 22 of of IN cord-005453-4057qib7 10204 23 the the DT cord-005453-4057qib7 10204 24 viruses virus NNS cord-005453-4057qib7 10204 25 showed show VBD cord-005453-4057qib7 10204 26 a a DT cord-005453-4057qib7 10204 27 clear clear JJ cord-005453-4057qib7 10204 28 seasonal seasonal JJ cord-005453-4057qib7 10204 29 pattern pattern NN cord-005453-4057qib7 10204 30 ( ( -LRB- cord-005453-4057qib7 10204 31 November November NNP cord-005453-4057qib7 10204 32 to to IN cord-005453-4057qib7 10204 33 April April NNP cord-005453-4057qib7 10204 34 ) ) -RRB- cord-005453-4057qib7 10204 35 . . . cord-005453-4057qib7 10205 1 [ [ -LRB- cord-005453-4057qib7 10205 2 [ [ -LRB- cord-005453-4057qib7 10205 3 P452 p452 JJ cord-005453-4057qib7 10205 4 Image image NN cord-005453-4057qib7 10205 5 ] ] -RRB- cord-005453-4057qib7 10205 6 1 1 CD cord-005453-4057qib7 10205 7 . . . cord-005453-4057qib7 10206 1 Background background NN cord-005453-4057qib7 10206 2 : : : cord-005453-4057qib7 10207 1 Trimethoprim Trimethoprim NNP cord-005453-4057qib7 10207 2 - - HYPH cord-005453-4057qib7 10207 3 sulfamethoxazole sulfamethoxazole NNP cord-005453-4057qib7 10207 4 ( ( -LRB- cord-005453-4057qib7 10207 5 TMP TMP NNP cord-005453-4057qib7 10207 6 - - HYPH cord-005453-4057qib7 10207 7 SMX SMX NNP cord-005453-4057qib7 10207 8 ) ) -RRB- cord-005453-4057qib7 10207 9 is be VBZ cord-005453-4057qib7 10207 10 the the DT cord-005453-4057qib7 10207 11 most most RBS cord-005453-4057qib7 10207 12 suitable suitable JJ cord-005453-4057qib7 10207 13 drug drug NN cord-005453-4057qib7 10207 14 for for IN cord-005453-4057qib7 10207 15 prophylaxis prophylaxis NN cord-005453-4057qib7 10207 16 against against IN cord-005453-4057qib7 10207 17 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 10207 18 pneumonia pneumonia NN cord-005453-4057qib7 10207 19 and and CC cord-005453-4057qib7 10207 20 infections infection NNS cord-005453-4057qib7 10207 21 with with IN cord-005453-4057qib7 10207 22 Toxoplasma toxoplasma NN cord-005453-4057qib7 10207 23 after after IN cord-005453-4057qib7 10207 24 allogeneic allogeneic JJ cord-005453-4057qib7 10207 25 haematopoietic haematopoietic JJ cord-005453-4057qib7 10207 26 stem stem NN cord-005453-4057qib7 10207 27 cell cell NN cord-005453-4057qib7 10207 28 transplantation transplantation NN cord-005453-4057qib7 10207 29 ( ( -LRB- cord-005453-4057qib7 10207 30 allo allo NN cord-005453-4057qib7 10207 31 - - HYPH cord-005453-4057qib7 10207 32 HSCT HSCT NNP cord-005453-4057qib7 10207 33 ) ) -RRB- cord-005453-4057qib7 10207 34 . . . cord-005453-4057qib7 10208 1 Allergic allergic JJ cord-005453-4057qib7 10208 2 reactions reaction NNS cord-005453-4057qib7 10208 3 or or CC cord-005453-4057qib7 10208 4 hypersensitivities hypersensitivity NNS cord-005453-4057qib7 10208 5 , , , cord-005453-4057qib7 10208 6 mainly mainly RB cord-005453-4057qib7 10208 7 exanthemas exanthemas NNP cord-005453-4057qib7 10208 8 , , , cord-005453-4057qib7 10208 9 occur occur VBP cord-005453-4057qib7 10208 10 in in IN cord-005453-4057qib7 10208 11 about about RB cord-005453-4057qib7 10208 12 3 3 CD cord-005453-4057qib7 10208 13 - - SYM cord-005453-4057qib7 10208 14 5 5 CD cord-005453-4057qib7 10208 15 % % NN cord-005453-4057qib7 10208 16 of of IN cord-005453-4057qib7 10208 17 the the DT cord-005453-4057qib7 10208 18 patients patient NNS cord-005453-4057qib7 10208 19 , , , cord-005453-4057qib7 10208 20 usually usually RB cord-005453-4057qib7 10208 21 resulting result VBG cord-005453-4057qib7 10208 22 in in IN cord-005453-4057qib7 10208 23 the the DT cord-005453-4057qib7 10208 24 use use NN cord-005453-4057qib7 10208 25 of of IN cord-005453-4057qib7 10208 26 alternative alternative JJ cord-005453-4057qib7 10208 27 prophylactic prophylactic JJ cord-005453-4057qib7 10208 28 drugs drug NNS cord-005453-4057qib7 10208 29 ( ( -LRB- cord-005453-4057qib7 10208 30 e.g. e.g. RB cord-005453-4057qib7 10208 31 pentamidine pentamidine NNP cord-005453-4057qib7 10208 32 or or CC cord-005453-4057qib7 10208 33 atovaquone atovaquone NNP cord-005453-4057qib7 10208 34 ) ) -RRB- cord-005453-4057qib7 10208 35 . . . cord-005453-4057qib7 10209 1 It -PRON- PRP cord-005453-4057qib7 10209 2 has have VBZ cord-005453-4057qib7 10209 3 been be VBN cord-005453-4057qib7 10209 4 hypothesised hypothesise VBN cord-005453-4057qib7 10209 5 that that IN cord-005453-4057qib7 10209 6 allergies allergy NNS cord-005453-4057qib7 10209 7 might may MD cord-005453-4057qib7 10209 8 be be VB cord-005453-4057qib7 10209 9 cured cure VBN cord-005453-4057qib7 10209 10 with with IN cord-005453-4057qib7 10209 11 allo allo NN cord-005453-4057qib7 10209 12 - - HYPH cord-005453-4057qib7 10209 13 HSCT HSCT NNP cord-005453-4057qib7 10209 14 . . . cord-005453-4057qib7 10210 1 Methods method NNS cord-005453-4057qib7 10210 2 : : : cord-005453-4057qib7 10210 3 We -PRON- PRP cord-005453-4057qib7 10210 4 conducted conduct VBD cord-005453-4057qib7 10210 5 a a DT cord-005453-4057qib7 10210 6 retrospective retrospective JJ cord-005453-4057qib7 10210 7 chart chart NN cord-005453-4057qib7 10210 8 review review NN cord-005453-4057qib7 10210 9 of of IN cord-005453-4057qib7 10210 10 patients patient NNS cord-005453-4057qib7 10210 11 with with IN cord-005453-4057qib7 10210 12 TMP TMP NNP cord-005453-4057qib7 10210 13 - - HYPH cord-005453-4057qib7 10210 14 SMX smx NN cord-005453-4057qib7 10210 15 re re NN cord-005453-4057qib7 10210 16 - - NN cord-005453-4057qib7 10210 17 exposition exposition NN cord-005453-4057qib7 10210 18 after after IN cord-005453-4057qib7 10210 19 allo allo NN cord-005453-4057qib7 10210 20 - - HYPH cord-005453-4057qib7 10210 21 HSCT HSCT NNP cord-005453-4057qib7 10210 22 from from IN cord-005453-4057qib7 10210 23 December December NNP cord-005453-4057qib7 10210 24 2017 2017 CD cord-005453-4057qib7 10210 25 to to IN cord-005453-4057qib7 10210 26 September September NNP cord-005453-4057qib7 10210 27 2018 2018 CD cord-005453-4057qib7 10210 28 . . . cord-005453-4057qib7 10211 1 Follow follow VB cord-005453-4057qib7 10211 2 - - HYPH cord-005453-4057qib7 10211 3 up up NN cord-005453-4057qib7 10211 4 is be VBZ cord-005453-4057qib7 10211 5 current current JJ cord-005453-4057qib7 10211 6 as as IN cord-005453-4057qib7 10211 7 of of IN cord-005453-4057qib7 10211 8 December December NNP cord-005453-4057qib7 10211 9 2018 2018 CD cord-005453-4057qib7 10211 10 . . . cord-005453-4057qib7 10212 1 Results result NNS cord-005453-4057qib7 10212 2 : : : cord-005453-4057qib7 10213 1 Six six CD cord-005453-4057qib7 10213 2 patients patient NNS cord-005453-4057qib7 10213 3 ( ( -LRB- cord-005453-4057qib7 10213 4 f f NNP cord-005453-4057qib7 10213 5 / / SYM cord-005453-4057qib7 10213 6 m m NN cord-005453-4057qib7 10213 7 : : : cord-005453-4057qib7 10213 8 4/2 4/2 CD cord-005453-4057qib7 10213 9 , , , cord-005453-4057qib7 10213 10 median median JJ cord-005453-4057qib7 10213 11 age age NN cord-005453-4057qib7 10213 12 : : : cord-005453-4057qib7 10213 13 45 45 CD cord-005453-4057qib7 10213 14 years year NNS cord-005453-4057qib7 10213 15 , , , cord-005453-4057qib7 10213 16 range range NN cord-005453-4057qib7 10213 17 : : : cord-005453-4057qib7 10213 18 25 25 CD cord-005453-4057qib7 10214 1 -66 -66 CD cord-005453-4057qib7 10214 2 years year NNS cord-005453-4057qib7 10214 3 ) ) -RRB- cord-005453-4057qib7 10214 4 with with IN cord-005453-4057qib7 10214 5 a a DT cord-005453-4057qib7 10214 6 history history NN cord-005453-4057qib7 10214 7 of of IN cord-005453-4057qib7 10214 8 TMP TMP NNP cord-005453-4057qib7 10214 9 - - HYPH cord-005453-4057qib7 10214 10 SMX smx NN cord-005453-4057qib7 10214 11 hypersensitivity hypersensitivity NN cord-005453-4057qib7 10214 12 prior prior RB cord-005453-4057qib7 10214 13 to to IN cord-005453-4057qib7 10214 14 allo allo NN cord-005453-4057qib7 10214 15 - - HYPH cord-005453-4057qib7 10214 16 HSCT HSCT NNP cord-005453-4057qib7 10215 1 were be VBD cord-005453-4057qib7 10215 2 re re VBN cord-005453-4057qib7 10215 3 - - VBN cord-005453-4057qib7 10215 4 exposed expose VBN cord-005453-4057qib7 10215 5 to to IN cord-005453-4057qib7 10215 6 TMP TMP NNP cord-005453-4057qib7 10215 7 - - HYPH cord-005453-4057qib7 10215 8 SMX SMX NNP cord-005453-4057qib7 10215 9 after after IN cord-005453-4057qib7 10215 10 engraftment engraftment NN cord-005453-4057qib7 10215 11 of of IN cord-005453-4057qib7 10215 12 a a DT cord-005453-4057qib7 10215 13 matched match VBN cord-005453-4057qib7 10215 14 related relate VBN cord-005453-4057qib7 10215 15 ( ( -LRB- cord-005453-4057qib7 10215 16 MRD MRD NNP cord-005453-4057qib7 10215 17 , , , cord-005453-4057qib7 10215 18 n=1 n=1 CD cord-005453-4057qib7 10215 19 ) ) -RRB- cord-005453-4057qib7 10215 20 or or CC cord-005453-4057qib7 10215 21 matched match VBN cord-005453-4057qib7 10215 22 unrelated unrelated JJ cord-005453-4057qib7 10215 23 ( ( -LRB- cord-005453-4057qib7 10215 24 MUD mud NN cord-005453-4057qib7 10215 25 , , , cord-005453-4057qib7 10215 26 n=5 n=5 JJ cord-005453-4057qib7 10215 27 ) ) -RRB- cord-005453-4057qib7 10215 28 donor donor NN cord-005453-4057qib7 10215 29 . . . cord-005453-4057qib7 10216 1 Median median JJ cord-005453-4057qib7 10216 2 time time NN cord-005453-4057qib7 10216 3 to to TO cord-005453-4057qib7 10216 4 re re VB cord-005453-4057qib7 10216 5 - - NN cord-005453-4057qib7 10216 6 exposition exposition NN cord-005453-4057qib7 10216 7 was be VBD cord-005453-4057qib7 10216 8 18.5 18.5 CD cord-005453-4057qib7 10217 1 ( ( -LRB- cord-005453-4057qib7 10217 2 range range NN cord-005453-4057qib7 10217 3 : : : cord-005453-4057qib7 10217 4 11 11 CD cord-005453-4057qib7 10217 5 - - SYM cord-005453-4057qib7 10217 6 341 341 CD cord-005453-4057qib7 10217 7 ) ) -RRB- cord-005453-4057qib7 10217 8 days day NNS cord-005453-4057qib7 10217 9 after after IN cord-005453-4057qib7 10217 10 allo allo NN cord-005453-4057qib7 10217 11 - - HYPH cord-005453-4057qib7 10217 12 HSCT HSCT NNP cord-005453-4057qib7 10217 13 with with IN cord-005453-4057qib7 10217 14 one one CD cord-005453-4057qib7 10217 15 oral oral JJ cord-005453-4057qib7 10217 16 dose dose NN cord-005453-4057qib7 10217 17 of of IN cord-005453-4057qib7 10217 18 TMP TMP NNP cord-005453-4057qib7 10217 19 - - HYPH cord-005453-4057qib7 10217 20 SMX SMX NNP cord-005453-4057qib7 10217 21 . . . cord-005453-4057qib7 10218 1 In in IN cord-005453-4057qib7 10218 2 four four CD cord-005453-4057qib7 10218 3 patients patient NNS cord-005453-4057qib7 10218 4 , , , cord-005453-4057qib7 10218 5 TMP TMP NNP cord-005453-4057qib7 10218 6 - - HYPH cord-005453-4057qib7 10218 7 SMX SMX NNP cord-005453-4057qib7 10218 8 was be VBD cord-005453-4057qib7 10218 9 tolerated tolerate VBN cord-005453-4057qib7 10218 10 without without IN cord-005453-4057qib7 10218 11 any any DT cord-005453-4057qib7 10218 12 signs sign NNS cord-005453-4057qib7 10218 13 of of IN cord-005453-4057qib7 10218 14 hypersensitivity hypersensitivity NN cord-005453-4057qib7 10218 15 reactions reaction NNS cord-005453-4057qib7 10218 16 and and CC cord-005453-4057qib7 10218 17 has have VBZ cord-005453-4057qib7 10218 18 been be VBN cord-005453-4057qib7 10218 19 continued continue VBN cord-005453-4057qib7 10218 20 for for IN cord-005453-4057qib7 10218 21 a a DT cord-005453-4057qib7 10218 22 median median NN cord-005453-4057qib7 10218 23 of of IN cord-005453-4057qib7 10218 24 231 231 CD cord-005453-4057qib7 10218 25 days day NNS cord-005453-4057qib7 10218 26 ( ( -LRB- cord-005453-4057qib7 10218 27 range range VBP cord-005453-4057qib7 10218 28 87 87 CD cord-005453-4057qib7 10218 29 - - SYM cord-005453-4057qib7 10218 30 315 315 CD cord-005453-4057qib7 10218 31 ) ) -RRB- cord-005453-4057qib7 10218 32 until until IN cord-005453-4057qib7 10218 33 last last JJ cord-005453-4057qib7 10218 34 followup followup NN cord-005453-4057qib7 10218 35 . . . cord-005453-4057qib7 10219 1 One one CD cord-005453-4057qib7 10219 2 patient patient NN cord-005453-4057qib7 10219 3 ( ( -LRB- cord-005453-4057qib7 10219 4 MUD mud NN cord-005453-4057qib7 10219 5 , , , cord-005453-4057qib7 10219 6 re re NN cord-005453-4057qib7 10219 7 - - NN cord-005453-4057qib7 10219 8 exposition exposition NN cord-005453-4057qib7 10219 9 at at IN cord-005453-4057qib7 10219 10 d+341 d+341 NNP cord-005453-4057qib7 10219 11 ) ) -RRB- cord-005453-4057qib7 10219 12 experienced experience VBD cord-005453-4057qib7 10219 13 pruritus pruritus NN cord-005453-4057qib7 10219 14 and and CC cord-005453-4057qib7 10219 15 erythema erythema NN cord-005453-4057qib7 10219 16 some some DT cord-005453-4057qib7 10219 17 hours hour NNS cord-005453-4057qib7 10219 18 after after IN cord-005453-4057qib7 10219 19 tablet tablet NN cord-005453-4057qib7 10219 20 intake intake NN cord-005453-4057qib7 10219 21 . . . cord-005453-4057qib7 10220 1 Another another DT cord-005453-4057qib7 10220 2 patient patient NN cord-005453-4057qib7 10220 3 ( ( -LRB- cord-005453-4057qib7 10220 4 MUD mud NN cord-005453-4057qib7 10220 5 , , , cord-005453-4057qib7 10220 6 re re NN cord-005453-4057qib7 10220 7 - - NN cord-005453-4057qib7 10220 8 exposition exposition NN cord-005453-4057qib7 10220 9 at at IN cord-005453-4057qib7 10220 10 d+18 d+18 ADD cord-005453-4057qib7 10220 11 ) ) -RRB- cord-005453-4057qib7 10220 12 developed develop VBD cord-005453-4057qib7 10220 13 an an DT cord-005453-4057qib7 10220 14 exanthema exanthema JJ cord-005453-4057qib7 10220 15 one one CD cord-005453-4057qib7 10220 16 day day NN cord-005453-4057qib7 10220 17 after after IN cord-005453-4057qib7 10220 18 re re NN cord-005453-4057qib7 10220 19 - - NN cord-005453-4057qib7 10220 20 exposition exposition NN cord-005453-4057qib7 10220 21 which which WDT cord-005453-4057qib7 10220 22 was be VBD cord-005453-4057qib7 10220 23 later later RB cord-005453-4057qib7 10220 24 diagnosed diagnose VBN cord-005453-4057qib7 10220 25 as as IN cord-005453-4057qib7 10220 26 a a DT cord-005453-4057qib7 10220 27 cutaneous cutaneous JJ cord-005453-4057qib7 10220 28 GvHD gvhd NN cord-005453-4057qib7 10220 29 . . . cord-005453-4057qib7 10221 1 Conclusions conclusion NNS cord-005453-4057qib7 10221 2 : : : cord-005453-4057qib7 10222 1 Re re NN cord-005453-4057qib7 10222 2 - - NN cord-005453-4057qib7 10222 3 exposition exposition NN cord-005453-4057qib7 10222 4 of of IN cord-005453-4057qib7 10222 5 TMP TMP NNP cord-005453-4057qib7 10222 6 - - HYPH cord-005453-4057qib7 10222 7 SMX SMX NNP cord-005453-4057qib7 10222 8 in in IN cord-005453-4057qib7 10222 9 patients patient NNS cord-005453-4057qib7 10222 10 with with IN cord-005453-4057qib7 10222 11 prior prior JJ cord-005453-4057qib7 10222 12 hypersensitivity hypersensitivity NN cord-005453-4057qib7 10222 13 is be VBZ cord-005453-4057qib7 10222 14 feasible feasible JJ cord-005453-4057qib7 10222 15 after after IN cord-005453-4057qib7 10222 16 allo allo NN cord-005453-4057qib7 10222 17 - - HYPH cord-005453-4057qib7 10222 18 HSCT HSCT NNP cord-005453-4057qib7 10222 19 . . . cord-005453-4057qib7 10223 1 After after IN cord-005453-4057qib7 10223 2 successful successful JJ cord-005453-4057qib7 10223 3 re re NN cord-005453-4057qib7 10223 4 - - NN cord-005453-4057qib7 10223 5 exposition exposition NN cord-005453-4057qib7 10223 6 , , , cord-005453-4057qib7 10223 7 patients patient NNS cord-005453-4057qib7 10223 8 can can MD cord-005453-4057qib7 10223 9 be be VB cord-005453-4057qib7 10223 10 treated treat VBN cord-005453-4057qib7 10223 11 with with IN cord-005453-4057qib7 10223 12 the the DT cord-005453-4057qib7 10223 13 best well RBS cord-005453-4057qib7 10223 14 - - HYPH cord-005453-4057qib7 10223 15 studied study VBN cord-005453-4057qib7 10223 16 drug drug NN cord-005453-4057qib7 10223 17 for for IN cord-005453-4057qib7 10223 18 prophylaxis prophylaxis NN cord-005453-4057qib7 10223 19 of of IN cord-005453-4057qib7 10223 20 infections infection NNS cord-005453-4057qib7 10223 21 with with IN cord-005453-4057qib7 10223 22 Pneumocystis Pneumocystis NNP cord-005453-4057qib7 10223 23 and and CC cord-005453-4057qib7 10223 24 Toxoplasma Toxoplasma NNP cord-005453-4057qib7 10223 25 . . . cord-005453-4057qib7 10224 1 Disclosure disclosure NN cord-005453-4057qib7 10224 2 : : : cord-005453-4057qib7 10224 3 Nothing nothing NN cord-005453-4057qib7 10224 4 to to TO cord-005453-4057qib7 10224 5 declare declare VB cord-005453-4057qib7 10224 6 Brincidofovir Brincidofovir NNP cord-005453-4057qib7 10224 7 for for IN cord-005453-4057qib7 10224 8 adenoviremia adenoviremia NN cord-005453-4057qib7 10224 9 in in IN cord-005453-4057qib7 10224 10 paediatric paediatric JJ cord-005453-4057qib7 10224 11 HSCT HSCT NNP cord-005453-4057qib7 10224 12 for for IN cord-005453-4057qib7 10224 13 primary primary JJ cord-005453-4057qib7 10224 14 immune immune JJ cord-005453-4057qib7 10224 15 deficiency deficiency NN cord-005453-4057qib7 10225 1 Background background NN cord-005453-4057qib7 10225 2 : : : cord-005453-4057qib7 10225 3 Reactivation reactivation NN cord-005453-4057qib7 10225 4 of of IN cord-005453-4057qib7 10225 5 adenovirus adenovirus NN cord-005453-4057qib7 10225 6 is be VBZ cord-005453-4057qib7 10225 7 a a DT cord-005453-4057qib7 10225 8 severe severe JJ cord-005453-4057qib7 10225 9 complication complication NN cord-005453-4057qib7 10225 10 of of IN cord-005453-4057qib7 10225 11 HSCT HSCT NNP cord-005453-4057qib7 10225 12 associated associate VBN cord-005453-4057qib7 10225 13 with with IN cord-005453-4057qib7 10225 14 significant significant JJ cord-005453-4057qib7 10225 15 morbidity morbidity NN cord-005453-4057qib7 10225 16 and and CC cord-005453-4057qib7 10225 17 mortality mortality NN cord-005453-4057qib7 10225 18 , , , cord-005453-4057qib7 10225 19 particularly particularly RB cord-005453-4057qib7 10225 20 for for IN cord-005453-4057qib7 10225 21 children child NNS cord-005453-4057qib7 10225 22 with with IN cord-005453-4057qib7 10225 23 primary primary JJ cord-005453-4057qib7 10225 24 immune immune JJ cord-005453-4057qib7 10225 25 deficiency deficiency NN cord-005453-4057qib7 10225 26 ( ( -LRB- cord-005453-4057qib7 10225 27 PID PID NNP cord-005453-4057qib7 10225 28 ) ) -RRB- cord-005453-4057qib7 10225 29 . . . cord-005453-4057qib7 10226 1 The the DT cord-005453-4057qib7 10226 2 only only JJ cord-005453-4057qib7 10226 3 drug drug NN cord-005453-4057qib7 10226 4 currently currently RB cord-005453-4057qib7 10226 5 licensed license VBN cord-005453-4057qib7 10226 6 to to TO cord-005453-4057qib7 10226 7 treat treat VB cord-005453-4057qib7 10226 8 adenovirus adenovirus NN cord-005453-4057qib7 10226 9 infection infection NN cord-005453-4057qib7 10226 10 is be VBZ cord-005453-4057qib7 10226 11 cidofovir cidofovir NNS cord-005453-4057qib7 10226 12 . . . cord-005453-4057qib7 10227 1 Brincidofovir Brincidofovir NNP cord-005453-4057qib7 10227 2 is be VBZ cord-005453-4057qib7 10227 3 a a DT cord-005453-4057qib7 10227 4 lipidlinked lipidlinked JJ cord-005453-4057qib7 10227 5 derivative derivative NN cord-005453-4057qib7 10227 6 of of IN cord-005453-4057qib7 10227 7 cidofovir cidofovir NNS cord-005453-4057qib7 10227 8 which which WDT cord-005453-4057qib7 10227 9 has have VBZ cord-005453-4057qib7 10227 10 been be VBN cord-005453-4057qib7 10227 11 shown show VBN cord-005453-4057qib7 10227 12 to to TO cord-005453-4057qib7 10227 13 be be VB cord-005453-4057qib7 10227 14 a a DT cord-005453-4057qib7 10227 15 safe safe JJ cord-005453-4057qib7 10227 16 and and CC cord-005453-4057qib7 10227 17 effective effective JJ cord-005453-4057qib7 10227 18 alternative alternative JJ cord-005453-4057qib7 10227 19 treatment treatment NN cord-005453-4057qib7 10227 20 to to IN cord-005453-4057qib7 10227 21 cidofovir cidofovir NNS cord-005453-4057qib7 10227 22 . . . cord-005453-4057qib7 10228 1 There there EX cord-005453-4057qib7 10228 2 is be VBZ cord-005453-4057qib7 10228 3 limited limited JJ cord-005453-4057qib7 10228 4 data datum NNS cord-005453-4057qib7 10228 5 describing describe VBG cord-005453-4057qib7 10228 6 the the DT cord-005453-4057qib7 10228 7 use use NN cord-005453-4057qib7 10228 8 of of IN cord-005453-4057qib7 10228 9 brincidofovir brincidofovir NNS cord-005453-4057qib7 10228 10 in in IN cord-005453-4057qib7 10228 11 patients patient NNS cord-005453-4057qib7 10228 12 undergoing undergo VBG cord-005453-4057qib7 10228 13 HSCT HSCT NNP cord-005453-4057qib7 10228 14 for for IN cord-005453-4057qib7 10228 15 primary primary JJ cord-005453-4057qib7 10228 16 immune immune JJ cord-005453-4057qib7 10228 17 deficiency deficiency NN cord-005453-4057qib7 10228 18 . . . cord-005453-4057qib7 10229 1 We -PRON- PRP cord-005453-4057qib7 10229 2 reviewed review VBD cord-005453-4057qib7 10229 3 all all DT cord-005453-4057qib7 10229 4 patients patient NNS cord-005453-4057qib7 10229 5 who who WP cord-005453-4057qib7 10229 6 received receive VBD cord-005453-4057qib7 10229 7 brincidofovir brincidofovir NNS cord-005453-4057qib7 10229 8 after after IN cord-005453-4057qib7 10229 9 undergoing undergo VBG cord-005453-4057qib7 10229 10 HSCT HSCT NNP cord-005453-4057qib7 10229 11 for for IN cord-005453-4057qib7 10229 12 primary primary JJ cord-005453-4057qib7 10229 13 immune immune JJ cord-005453-4057qib7 10229 14 deficiencies deficiency NNS cord-005453-4057qib7 10229 15 between between IN cord-005453-4057qib7 10229 16 2016 2016 CD cord-005453-4057qib7 10229 17 and and CC cord-005453-4057qib7 10229 18 2018 2018 CD cord-005453-4057qib7 10229 19 at at IN cord-005453-4057qib7 10229 20 the the DT cord-005453-4057qib7 10229 21 Great Great NNP cord-005453-4057qib7 10229 22 North North NNP cord-005453-4057qib7 10229 23 Children Children NNPS cord-005453-4057qib7 10229 24 's 's POS cord-005453-4057qib7 10229 25 Hospital Hospital NNP cord-005453-4057qib7 10229 26 , , , cord-005453-4057qib7 10229 27 Newcastle Newcastle NNP cord-005453-4057qib7 10229 28 Upon upon IN cord-005453-4057qib7 10229 29 Tyne Tyne NNP cord-005453-4057qib7 10229 30 , , , cord-005453-4057qib7 10229 31 UK UK NNP cord-005453-4057qib7 10229 32 . . . cord-005453-4057qib7 10230 1 Results result NNS cord-005453-4057qib7 10230 2 : : : cord-005453-4057qib7 10231 1 Of of IN cord-005453-4057qib7 10231 2 78 78 CD cord-005453-4057qib7 10231 3 patients patient NNS cord-005453-4057qib7 10231 4 transplanted transplant VBN cord-005453-4057qib7 10231 5 for for IN cord-005453-4057qib7 10231 6 PID PID NNP cord-005453-4057qib7 10231 7 , , , cord-005453-4057qib7 10231 8 11 11 CD cord-005453-4057qib7 10231 9 developed develop VBD cord-005453-4057qib7 10231 10 significant significant JJ cord-005453-4057qib7 10231 11 adenoviraemia adenoviraemia NN cord-005453-4057qib7 10231 12 ( ( -LRB- cord-005453-4057qib7 10231 13 14 14 CD cord-005453-4057qib7 10231 14 % % NN cord-005453-4057qib7 10231 15 ) ) -RRB- cord-005453-4057qib7 10231 16 . . . cord-005453-4057qib7 10232 1 All all DT cord-005453-4057qib7 10232 2 were be VBD cord-005453-4057qib7 10232 3 treated treat VBN cord-005453-4057qib7 10232 4 with with IN cord-005453-4057qib7 10232 5 cidofovir cidofovir NNS cord-005453-4057qib7 10232 6 initially initially RB cord-005453-4057qib7 10232 7 but but CC cord-005453-4057qib7 10232 8 6 6 CD cord-005453-4057qib7 10232 9 were be VBD cord-005453-4057qib7 10232 10 switched switch VBN cord-005453-4057qib7 10232 11 to to IN cord-005453-4057qib7 10232 12 brincidofovir brincidofovir NNS cord-005453-4057qib7 10232 13 because because IN cord-005453-4057qib7 10232 14 of of IN cord-005453-4057qib7 10232 15 a a DT cord-005453-4057qib7 10232 16 failure failure NN cord-005453-4057qib7 10232 17 to to TO cord-005453-4057qib7 10232 18 respond respond VB cord-005453-4057qib7 10232 19 or or CC cord-005453-4057qib7 10232 20 because because IN cord-005453-4057qib7 10232 21 of of IN cord-005453-4057qib7 10232 22 renal renal JJ cord-005453-4057qib7 10232 23 toxicity toxicity NN cord-005453-4057qib7 10232 24 . . . cord-005453-4057qib7 10233 1 Of of IN cord-005453-4057qib7 10233 2 these these DT cord-005453-4057qib7 10233 3 , , , cord-005453-4057qib7 10233 4 4 4 CD cord-005453-4057qib7 10233 5 resolved resolve VBD cord-005453-4057qib7 10233 6 their -PRON- PRP$ cord-005453-4057qib7 10233 7 adenoviraemia adenoviraemia NN cord-005453-4057qib7 10233 8 within within IN cord-005453-4057qib7 10233 9 21 21 CD cord-005453-4057qib7 10233 10 days day NNS cord-005453-4057qib7 10233 11 of of IN cord-005453-4057qib7 10233 12 commencing commence VBG cord-005453-4057qib7 10233 13 treatment treatment NN cord-005453-4057qib7 10233 14 ( ( -LRB- cord-005453-4057qib7 10233 15 figure figure NN cord-005453-4057qib7 10233 16 1 1 CD cord-005453-4057qib7 10233 17 ) ) -RRB- cord-005453-4057qib7 10233 18 . . . cord-005453-4057qib7 10234 1 Donor donor NN cord-005453-4057qib7 10234 2 sources source NNS cord-005453-4057qib7 10234 3 were be VBD cord-005453-4057qib7 10234 4 TCR TCR NNP cord-005453-4057qib7 10235 1 alpha alpha NN cord-005453-4057qib7 10235 2 / / SYM cord-005453-4057qib7 10235 3 beta beta NN cord-005453-4057qib7 10236 1 /CD19 /CD19 NNP cord-005453-4057qib7 10236 2 depleted deplete VBN cord-005453-4057qib7 10236 3 haplo haplo NN cord-005453-4057qib7 10236 4 - - HYPH cord-005453-4057qib7 10236 5 identical identical JJ cord-005453-4057qib7 10236 6 ( ( -LRB- cord-005453-4057qib7 10236 7 n=4 n=4 JJ cord-005453-4057qib7 10236 8 ) ) -RRB- cord-005453-4057qib7 10237 1 , , , cord-005453-4057qib7 10237 2 TCR TCR NNP cord-005453-4057qib7 10237 3 alpha alpha NN cord-005453-4057qib7 10237 4 / / SYM cord-005453-4057qib7 10237 5 beta beta NN cord-005453-4057qib7 10237 6 / / SYM cord-005453-4057qib7 10237 7 CD19 CD19 NNP cord-005453-4057qib7 10237 8 depleted deplete VBD cord-005453-4057qib7 10237 9 MMUD MMUD NNP cord-005453-4057qib7 10237 10 ( ( -LRB- cord-005453-4057qib7 10237 11 n=1 n=1 NN cord-005453-4057qib7 10237 12 ) ) -RRB- cord-005453-4057qib7 10237 13 and and CC cord-005453-4057qib7 10237 14 12/12 12/12 CD cord-005453-4057qib7 10237 15 MUD mud NN cord-005453-4057qib7 10237 16 ( ( -LRB- cord-005453-4057qib7 10237 17 n=1 n=1 FW cord-005453-4057qib7 10237 18 ) ) -RRB- cord-005453-4057qib7 10237 19 . . . cord-005453-4057qib7 10238 1 Patients patient NNS cord-005453-4057qib7 10238 2 were be VBD cord-005453-4057qib7 10238 3 conditioned condition VBN cord-005453-4057qib7 10238 4 with with IN cord-005453-4057qib7 10238 5 Treosulphan Treosulphan NNP cord-005453-4057qib7 10238 6 / / SYM cord-005453-4057qib7 10238 7 Fludarabine Fludarabine NNP cord-005453-4057qib7 10238 8 / / SYM cord-005453-4057qib7 10238 9 Thiotepa Thiotepa NNP cord-005453-4057qib7 10238 10 / / SYM cord-005453-4057qib7 10238 11 ATG/ ATG/ NNP cord-005453-4057qib7 10238 12 Rituximab Rituximab NNP cord-005453-4057qib7 10238 13 ( ( -LRB- cord-005453-4057qib7 10238 14 n=4 n=4 NNS cord-005453-4057qib7 10238 15 ) ) -RRB- cord-005453-4057qib7 10238 16 , , , cord-005453-4057qib7 10238 17 Treosulphan Treosulphan NNP cord-005453-4057qib7 10238 18 / / SYM cord-005453-4057qib7 10238 19 Fludarabine Fludarabine NNP cord-005453-4057qib7 10238 20 / / SYM cord-005453-4057qib7 10238 21 ATG ATG NNP cord-005453-4057qib7 10238 22 / / SYM cord-005453-4057qib7 10238 23 Rituximab Rituximab NNP cord-005453-4057qib7 10238 24 ( ( -LRB- cord-005453-4057qib7 10238 25 n=1 n=1 NN cord-005453-4057qib7 10238 26 ) ) -RRB- cord-005453-4057qib7 10238 27 or or CC cord-005453-4057qib7 10238 28 Treosulphan Treosulphan NNP cord-005453-4057qib7 10238 29 / / SYM cord-005453-4057qib7 10238 30 Fludarabine Fludarabine NNP cord-005453-4057qib7 10238 31 / / SYM cord-005453-4057qib7 10238 32 Alemtuzumab/ alemtuzumab/ CC cord-005453-4057qib7 10238 33 GCSF GCSF NNP cord-005453-4057qib7 10238 34 / / SYM cord-005453-4057qib7 10238 35 Plerixafor Plerixafor NNP cord-005453-4057qib7 10238 36 ( ( -LRB- cord-005453-4057qib7 10238 37 n=1 n=1 NN cord-005453-4057qib7 10238 38 ) ) -RRB- cord-005453-4057qib7 10238 39 . . . cord-005453-4057qib7 10239 1 Occurrence occurrence NN cord-005453-4057qib7 10239 2 of of IN cord-005453-4057qib7 10239 3 aGVHD agvhd NN cord-005453-4057qib7 10239 4 and and CC cord-005453-4057qib7 10239 5 treatment treatment NN cord-005453-4057qib7 10239 6 of of IN cord-005453-4057qib7 10239 7 aGVHD aGVHD NNP cord-005453-4057qib7 10239 8 are be VBP cord-005453-4057qib7 10239 9 outlined outline VBN cord-005453-4057qib7 10239 10 in in IN cord-005453-4057qib7 10239 11 table table NN cord-005453-4057qib7 10239 12 1 1 CD cord-005453-4057qib7 10239 13 . . . cord-005453-4057qib7 10240 1 Patient patient NN cord-005453-4057qib7 10240 2 5 5 CD cord-005453-4057qib7 10240 3 died die VBD cord-005453-4057qib7 10240 4 +111 +111 NNP cord-005453-4057qib7 10240 5 days day NNS cord-005453-4057qib7 10240 6 post post NN cord-005453-4057qib7 10240 7 - - NN cord-005453-4057qib7 10240 8 transplant transplant NN cord-005453-4057qib7 10240 9 of of IN cord-005453-4057qib7 10240 10 multi multi JJ cord-005453-4057qib7 10240 11 - - JJ cord-005453-4057qib7 10240 12 organ organ JJ cord-005453-4057qib7 10240 13 failure failure NN cord-005453-4057qib7 10240 14 , , , cord-005453-4057qib7 10240 15 severe severe JJ cord-005453-4057qib7 10240 16 thrombotic thrombotic JJ cord-005453-4057qib7 10240 17 microangiopathy microangiopathy NN cord-005453-4057qib7 10240 18 and and CC cord-005453-4057qib7 10240 19 sepsis sepsis NN cord-005453-4057qib7 10240 20 . . . cord-005453-4057qib7 10241 1 Although although IN cord-005453-4057qib7 10241 2 Patient Patient NNP cord-005453-4057qib7 10241 3 2 2 CD cord-005453-4057qib7 10241 4 initially initially RB cord-005453-4057qib7 10241 5 responded respond VBD cord-005453-4057qib7 10241 6 to to IN cord-005453-4057qib7 10241 7 brincidofovir brincidofovir NNS cord-005453-4057qib7 10241 8 , , , cord-005453-4057qib7 10241 9 reactivation reactivation NN cord-005453-4057qib7 10241 10 occurred occur VBD cord-005453-4057qib7 10241 11 after after IN cord-005453-4057qib7 10241 12 cessation cessation NN cord-005453-4057qib7 10241 13 of of IN cord-005453-4057qib7 10241 14 treatment treatment NN cord-005453-4057qib7 10241 15 ; ; : cord-005453-4057qib7 10241 16 severe severe JJ cord-005453-4057qib7 10241 17 diarrhoea diarrhoea NN cord-005453-4057qib7 10241 18 precluded preclude VBD cord-005453-4057qib7 10241 19 the the DT cord-005453-4057qib7 10241 20 reintroduction reintroduction NN cord-005453-4057qib7 10241 21 of of IN cord-005453-4057qib7 10241 22 brincidofovir brincidofovir NNS cord-005453-4057qib7 10241 23 and and CC cord-005453-4057qib7 10241 24 the the DT cord-005453-4057qib7 10241 25 adenoviraemia adenoviraemia NN cord-005453-4057qib7 10241 26 persisted persist VBD cord-005453-4057qib7 10241 27 with with IN cord-005453-4057qib7 10241 28 poor poor JJ cord-005453-4057qib7 10241 29 immune immune JJ cord-005453-4057qib7 10241 30 reconstitution reconstitution NN cord-005453-4057qib7 10241 31 . . . cord-005453-4057qib7 10242 1 Treatment treatment NN cord-005453-4057qib7 10242 2 with with IN cord-005453-4057qib7 10242 3 addback addback NNP cord-005453-4057qib7 10242 4 T T NNP cord-005453-4057qib7 10242 5 cells cell NNS cord-005453-4057qib7 10242 6 was be VBD cord-005453-4057qib7 10242 7 attempted attempt VBN cord-005453-4057qib7 10242 8 however however RB cord-005453-4057qib7 10242 9 the the DT cord-005453-4057qib7 10242 10 patient patient NN cord-005453-4057qib7 10242 11 died die VBD cord-005453-4057qib7 10242 12 194 194 CD cord-005453-4057qib7 10242 13 days day NNS cord-005453-4057qib7 10242 14 post post JJ cord-005453-4057qib7 10242 15 - - NN cord-005453-4057qib7 10242 16 transplant transplant NN cord-005453-4057qib7 10242 17 after after IN cord-005453-4057qib7 10242 18 a a DT cord-005453-4057qib7 10242 19 cerebral cerebral JJ cord-005453-4057qib7 10242 20 haemorrhage haemorrhage NN cord-005453-4057qib7 10242 21 . . . cord-005453-4057qib7 10243 1 Patient Patient NNP cord-005453-4057qib7 10243 2 3 3 CD cord-005453-4057qib7 10243 3 had have VBD cord-005453-4057qib7 10243 4 long long RB cord-005453-4057qib7 10243 5 - - HYPH cord-005453-4057qib7 10243 6 standing stand VBG cord-005453-4057qib7 10243 7 chronic chronic JJ cord-005453-4057qib7 10243 8 diarrhoea diarrhoea NN cord-005453-4057qib7 10243 9 which which WDT cord-005453-4057qib7 10243 10 was be VBD cord-005453-4057qib7 10243 11 thought think VBN cord-005453-4057qib7 10243 12 not not RB cord-005453-4057qib7 10243 13 severe severe JJ cord-005453-4057qib7 10243 14 enough enough RB cord-005453-4057qib7 10243 15 to to TO cord-005453-4057qib7 10243 16 warrant warrant VB cord-005453-4057qib7 10243 17 cessation cessation NN cord-005453-4057qib7 10243 18 of of IN cord-005453-4057qib7 10243 19 brincidofovir brincidofovir NNS cord-005453-4057qib7 10243 20 treatment treatment NN cord-005453-4057qib7 10243 21 . . . cord-005453-4057qib7 10244 1 Conclusions conclusion NNS cord-005453-4057qib7 10244 2 : : : cord-005453-4057qib7 10245 1 The the DT cord-005453-4057qib7 10245 2 complete complete JJ cord-005453-4057qib7 10245 3 resolution resolution NN cord-005453-4057qib7 10245 4 of of IN cord-005453-4057qib7 10245 5 adenoviraemia adenoviraemia NN cord-005453-4057qib7 10245 6 in in IN cord-005453-4057qib7 10245 7 4/6 4/6 CD cord-005453-4057qib7 10245 8 patients patient NNS cord-005453-4057qib7 10245 9 who who WP cord-005453-4057qib7 10245 10 had have VBD cord-005453-4057qib7 10245 11 previously previously RB cord-005453-4057qib7 10245 12 failed fail VBN cord-005453-4057qib7 10245 13 to to TO cord-005453-4057qib7 10245 14 respond respond VB cord-005453-4057qib7 10245 15 to to IN cord-005453-4057qib7 10245 16 prior prior JJ cord-005453-4057qib7 10245 17 therapy therapy NN cord-005453-4057qib7 10245 18 with with IN cord-005453-4057qib7 10245 19 cidofovir cidofovir NNP cord-005453-4057qib7 10245 20 suggests suggest VBZ cord-005453-4057qib7 10245 21 that that IN cord-005453-4057qib7 10245 22 brincidofovir brincidofovir NNS cord-005453-4057qib7 10245 23 may may MD cord-005453-4057qib7 10245 24 be be VB cord-005453-4057qib7 10245 25 an an DT cord-005453-4057qib7 10245 26 effective effective JJ cord-005453-4057qib7 10245 27 treatment treatment NN cord-005453-4057qib7 10245 28 option option NN cord-005453-4057qib7 10245 29 for for IN cord-005453-4057qib7 10245 30 adenoviral adenoviral NNP cord-005453-4057qib7 10245 31 reactivation reactivation NN cord-005453-4057qib7 10245 32 post post NN cord-005453-4057qib7 10245 33 - - JJ cord-005453-4057qib7 10245 34 HSCT HSCT NNP cord-005453-4057qib7 10245 35 for for IN cord-005453-4057qib7 10245 36 PID PID NNP cord-005453-4057qib7 10245 37 . . . cord-005453-4057qib7 10246 1 However however RB cord-005453-4057qib7 10246 2 , , , cord-005453-4057qib7 10246 3 resolution resolution NN cord-005453-4057qib7 10246 4 of of IN cord-005453-4057qib7 10246 5 adenoviraemia adenoviraemia NNP cord-005453-4057qib7 10246 6 is be VBZ cord-005453-4057qib7 10246 7 influenced influence VBN cord-005453-4057qib7 10246 8 by by IN cord-005453-4057qib7 10246 9 many many JJ cord-005453-4057qib7 10246 10 other other JJ cord-005453-4057qib7 10246 11 factors factor NNS cord-005453-4057qib7 10246 12 , , , cord-005453-4057qib7 10246 13 including include VBG cord-005453-4057qib7 10246 14 the the DT cord-005453-4057qib7 10246 15 adequacy adequacy NN cord-005453-4057qib7 10246 16 of of IN cord-005453-4057qib7 10246 17 immune immune JJ cord-005453-4057qib7 10246 18 reconstitution reconstitution NN cord-005453-4057qib7 10246 19 , , , cord-005453-4057qib7 10246 20 the the DT cord-005453-4057qib7 10246 21 degree degree NN cord-005453-4057qib7 10246 22 of of IN cord-005453-4057qib7 10246 23 induced induce VBN cord-005453-4057qib7 10246 24 immune immune JJ cord-005453-4057qib7 10246 25 suppression suppression NN cord-005453-4057qib7 10246 26 and and CC cord-005453-4057qib7 10246 27 the the DT cord-005453-4057qib7 10246 28 presence presence NN cord-005453-4057qib7 10246 29 of of IN cord-005453-4057qib7 10246 30 comorbidities comorbiditie NNS cord-005453-4057qib7 10246 31 such such JJ cord-005453-4057qib7 10246 32 as as IN cord-005453-4057qib7 10246 33 GVHD GVHD NNP cord-005453-4057qib7 10246 34 . . . cord-005453-4057qib7 10247 1 Due due IN cord-005453-4057qib7 10247 2 to to IN cord-005453-4057qib7 10247 3 the the DT cord-005453-4057qib7 10247 4 small small JJ cord-005453-4057qib7 10247 5 sample sample NN cord-005453-4057qib7 10247 6 size size NN cord-005453-4057qib7 10247 7 it -PRON- PRP cord-005453-4057qib7 10247 8 was be VBD cord-005453-4057qib7 10247 9 difficult difficult JJ cord-005453-4057qib7 10247 10 to to TO cord-005453-4057qib7 10247 11 assess assess VB cord-005453-4057qib7 10247 12 the the DT cord-005453-4057qib7 10247 13 relative relative JJ cord-005453-4057qib7 10247 14 importance importance NN cord-005453-4057qib7 10247 15 of of IN cord-005453-4057qib7 10247 16 these these DT cord-005453-4057qib7 10247 17 factors factor NNS cord-005453-4057qib7 10247 18 in in IN cord-005453-4057qib7 10247 19 this this DT cord-005453-4057qib7 10247 20 cohort cohort NN cord-005453-4057qib7 10247 21 . . . cord-005453-4057qib7 10248 1 Brincidofovir Brincidofovir NNP cord-005453-4057qib7 10248 2 was be VBD cord-005453-4057qib7 10248 3 well well RB cord-005453-4057qib7 10248 4 tolerated tolerate VBN cord-005453-4057qib7 10248 5 however however RB cord-005453-4057qib7 10248 6 its -PRON- PRP$ cord-005453-4057qib7 10248 7 effectiveness effectiveness NN cord-005453-4057qib7 10248 8 may may MD cord-005453-4057qib7 10248 9 have have VB cord-005453-4057qib7 10248 10 been be VBN cord-005453-4057qib7 10248 11 limited limit VBN cord-005453-4057qib7 10248 12 by by IN cord-005453-4057qib7 10248 13 poor poor JJ cord-005453-4057qib7 10248 14 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 10248 15 function function NN cord-005453-4057qib7 10248 16 in in IN cord-005453-4057qib7 10248 17 one one CD cord-005453-4057qib7 10248 18 patient patient NN cord-005453-4057qib7 10248 19 ( ( -LRB- cord-005453-4057qib7 10248 20 Patient Patient NNP cord-005453-4057qib7 10248 21 3 3 CD cord-005453-4057qib7 10248 22 ) ) -RRB- cord-005453-4057qib7 10248 23 and and CC cord-005453-4057qib7 10248 24 could could MD cord-005453-4057qib7 10248 25 not not RB cord-005453-4057qib7 10248 26 be be VB cord-005453-4057qib7 10248 27 used use VBN cord-005453-4057qib7 10248 28 after after IN cord-005453-4057qib7 10248 29 a a DT cord-005453-4057qib7 10248 30 viral viral JJ cord-005453-4057qib7 10248 31 reactivation reactivation NN cord-005453-4057qib7 10248 32 in in IN cord-005453-4057qib7 10248 33 another another DT cord-005453-4057qib7 10248 34 for for IN cord-005453-4057qib7 10248 35 the the DT cord-005453-4057qib7 10248 36 same same JJ cord-005453-4057qib7 10248 37 reason reason NN cord-005453-4057qib7 10248 38 . . . cord-005453-4057qib7 10249 1 Further further JJ cord-005453-4057qib7 10249 2 studies study NNS cord-005453-4057qib7 10249 3 of of IN cord-005453-4057qib7 10249 4 the the DT cord-005453-4057qib7 10249 5 use use NN cord-005453-4057qib7 10249 6 of of IN cord-005453-4057qib7 10249 7 brincidofovir brincidofovir NNS cord-005453-4057qib7 10249 8 in in IN cord-005453-4057qib7 10249 9 this this DT cord-005453-4057qib7 10249 10 specific specific JJ cord-005453-4057qib7 10249 11 cohort cohort NN cord-005453-4057qib7 10249 12 are be VBP cord-005453-4057qib7 10249 13 needed need VBN cord-005453-4057qib7 10249 14 to to TO cord-005453-4057qib7 10249 15 clarify clarify VB cord-005453-4057qib7 10249 16 the the DT cord-005453-4057qib7 10249 17 role role NN cord-005453-4057qib7 10249 18 and and CC cord-005453-4057qib7 10249 19 effectiveness effectiveness NN cord-005453-4057qib7 10249 20 of of IN cord-005453-4057qib7 10249 21 this this DT cord-005453-4057qib7 10249 22 treatment treatment NN cord-005453-4057qib7 10249 23 . . . cord-005453-4057qib7 10250 1 Background background NN cord-005453-4057qib7 10250 2 : : : cord-005453-4057qib7 10251 1 There there EX cord-005453-4057qib7 10251 2 is be VBZ cord-005453-4057qib7 10251 3 a a DT cord-005453-4057qib7 10251 4 high high JJ cord-005453-4057qib7 10251 5 prevalence prevalence NN cord-005453-4057qib7 10251 6 of of IN cord-005453-4057qib7 10251 7 CMV CMV NNP cord-005453-4057qib7 10251 8 seropositivity seropositivity NN cord-005453-4057qib7 10251 9 in in IN cord-005453-4057qib7 10251 10 Algerian algerian JJ cord-005453-4057qib7 10251 11 population population NN cord-005453-4057qib7 10251 12 . . . cord-005453-4057qib7 10252 1 Because because IN cord-005453-4057qib7 10252 2 of of IN cord-005453-4057qib7 10252 3 high high JJ cord-005453-4057qib7 10252 4 morbidity morbidity NN cord-005453-4057qib7 10252 5 and and CC cord-005453-4057qib7 10252 6 mortality mortality NN cord-005453-4057qib7 10252 7 in in IN cord-005453-4057qib7 10252 8 pts pt NNS cord-005453-4057qib7 10252 9 who who WP cord-005453-4057qib7 10252 10 underwent undergo VBD cord-005453-4057qib7 10252 11 allo allo NNP cord-005453-4057qib7 10252 12 SCT SCT NNP cord-005453-4057qib7 10252 13 with with IN cord-005453-4057qib7 10252 14 CMV CMV NNP cord-005453-4057qib7 10252 15 reactivation reactivation NN cord-005453-4057qib7 10252 16 , , , cord-005453-4057qib7 10252 17 effective effective JJ cord-005453-4057qib7 10252 18 surveillance surveillance NN cord-005453-4057qib7 10252 19 and and CC cord-005453-4057qib7 10252 20 timely timely JJ cord-005453-4057qib7 10252 21 treatment treatment NN cord-005453-4057qib7 10252 22 using use VBG cord-005453-4057qib7 10252 23 anti anti JJ cord-005453-4057qib7 10252 24 - - JJ cord-005453-4057qib7 10252 25 viral viral JJ cord-005453-4057qib7 10252 26 therapy therapy NN cord-005453-4057qib7 10252 27 s s NNS cord-005453-4057qib7 10252 28 required require VBN cord-005453-4057qib7 10252 29 . . . cord-005453-4057qib7 10253 1 The the DT cord-005453-4057qib7 10253 2 risk risk NN cord-005453-4057qib7 10253 3 of of IN cord-005453-4057qib7 10253 4 CMV CMV NNP cord-005453-4057qib7 10253 5 reactivation reactivation NN cord-005453-4057qib7 10253 6 depends depend VBZ cord-005453-4057qib7 10253 7 on on IN cord-005453-4057qib7 10253 8 the the DT cord-005453-4057qib7 10253 9 type type NN cord-005453-4057qib7 10253 10 of of IN cord-005453-4057qib7 10253 11 stem stem NN cord-005453-4057qib7 10253 12 cell cell NN cord-005453-4057qib7 10253 13 source source NN cord-005453-4057qib7 10253 14 , , , cord-005453-4057qib7 10253 15 immunosuppression immunosuppression NN cord-005453-4057qib7 10253 16 ( ( -LRB- cord-005453-4057qib7 10253 17 IS be VBZ cord-005453-4057qib7 10253 18 ) ) -RRB- cord-005453-4057qib7 10253 19 and and CC cord-005453-4057qib7 10253 20 serological serological JJ cord-005453-4057qib7 10253 21 status status NN cord-005453-4057qib7 10253 22 of of IN cord-005453-4057qib7 10253 23 the the DT cord-005453-4057qib7 10253 24 donor/ donor/ CD cord-005453-4057qib7 10253 25 recipient recipient NN cord-005453-4057qib7 10253 26 pair pair NN cord-005453-4057qib7 10253 27 . . . cord-005453-4057qib7 10254 1 Methods method NNS cord-005453-4057qib7 10254 2 : : : cord-005453-4057qib7 10254 3 over over IN cord-005453-4057qib7 10254 4 a a DT cord-005453-4057qib7 10254 5 24 24 CD cord-005453-4057qib7 10254 6 months month NNS cord-005453-4057qib7 10254 7 period period NN cord-005453-4057qib7 10254 8 ( ( -LRB- cord-005453-4057qib7 10254 9 from from IN cord-005453-4057qib7 10254 10 01/01/2016 01/01/2016 CD cord-005453-4057qib7 10254 11 to to IN cord-005453-4057qib7 10254 12 31/12/2017 31/12/2017 CD cord-005453-4057qib7 10254 13 ) ) -RRB- cord-005453-4057qib7 10254 14 , , , cord-005453-4057qib7 10254 15 254 254 CD cord-005453-4057qib7 10254 16 pts pt NNS cord-005453-4057qib7 10254 17 underwent undergo VBD cord-005453-4057qib7 10254 18 allo allo NN cord-005453-4057qib7 10254 19 - - HYPH cord-005453-4057qib7 10254 20 HSCT HSCT NNP cord-005453-4057qib7 10254 21 for for IN cord-005453-4057qib7 10254 22 malignant malignant JJ cord-005453-4057qib7 10254 23 or or CC cord-005453-4057qib7 10254 24 non non JJ cord-005453-4057qib7 10254 25 - - JJ cord-005453-4057qib7 10254 26 malignant malignant JJ cord-005453-4057qib7 10254 27 hematology hematology NN cord-005453-4057qib7 10254 28 diseases disease NNS cord-005453-4057qib7 10254 29 of of IN cord-005453-4057qib7 10254 30 which which WDT cord-005453-4057qib7 10254 31 246 246 CD cord-005453-4057qib7 10254 32 pts pt NNS cord-005453-4057qib7 10254 33 are be VBP cord-005453-4057qib7 10254 34 evaluated evaluate VBN cord-005453-4057qib7 10254 35 for for IN cord-005453-4057qib7 10254 36 this this DT cord-005453-4057qib7 10254 37 study study NN cord-005453-4057qib7 10254 38 . . . cord-005453-4057qib7 10255 1 CMV CMV NNP cord-005453-4057qib7 10255 2 reactivation reactivation NN cord-005453-4057qib7 10255 3 was be VBD cord-005453-4057qib7 10255 4 observed observe VBN cord-005453-4057qib7 10255 5 in in IN cord-005453-4057qib7 10255 6 66 66 CD cord-005453-4057qib7 10255 7 pts pt NNS cord-005453-4057qib7 10255 8 ( ( -LRB- cord-005453-4057qib7 10255 9 26.82 26.82 CD cord-005453-4057qib7 10255 10 % % NN cord-005453-4057qib7 10255 11 ) ) -RRB- cord-005453-4057qib7 10256 1 ( ( -LRB- cord-005453-4057qib7 10256 2 AML AML NNP cord-005453-4057qib7 10256 3 : : : cord-005453-4057qib7 10256 4 33 33 CD cord-005453-4057qib7 10256 5 pts pt NNS cord-005453-4057qib7 10256 6 , , , cord-005453-4057qib7 10256 7 ALL all DT cord-005453-4057qib7 10256 8 : : : cord-005453-4057qib7 10256 9 8 8 CD cord-005453-4057qib7 10256 10 pts pt NNS cord-005453-4057qib7 10256 11 , , , cord-005453-4057qib7 10256 12 CML CML NNP cord-005453-4057qib7 10256 13 : : : cord-005453-4057qib7 10256 14 4 4 CD cord-005453-4057qib7 10256 15 pts pt NNS cord-005453-4057qib7 10256 16 , , , cord-005453-4057qib7 10256 17 multiple multiple JJ cord-005453-4057qib7 10256 18 Myeloma myeloma NN cord-005453-4057qib7 10256 19 : : : cord-005453-4057qib7 10256 20 2 2 CD cord-005453-4057qib7 10256 21 pt pt NN cord-005453-4057qib7 10256 22 , , , cord-005453-4057qib7 10256 23 NHL NHL NNP cord-005453-4057qib7 10256 24 skin skin NN cord-005453-4057qib7 10256 25 : : : cord-005453-4057qib7 10256 26 1 1 CD cord-005453-4057qib7 10256 27 pt pt NN cord-005453-4057qib7 10256 28 , , , cord-005453-4057qib7 10256 29 primary primary JJ cord-005453-4057qib7 10256 30 myelofibrosis myelofibrosis NN cord-005453-4057qib7 10256 31 : : : cord-005453-4057qib7 10256 32 1 1 CD cord-005453-4057qib7 10256 33 pt pt NN cord-005453-4057qib7 10256 34 , , , cord-005453-4057qib7 10256 35 Aplastic aplastic JJ cord-005453-4057qib7 10256 36 anemia anemia NN cord-005453-4057qib7 10256 37 : : : cord-005453-4057qib7 10256 38 14 14 CD cord-005453-4057qib7 10256 39 pts pt NNS cord-005453-4057qib7 10256 40 , , , cord-005453-4057qib7 10256 41 Fanconi Fanconi NNP cord-005453-4057qib7 10256 42 anemia anemia NN cord-005453-4057qib7 10256 43 : : : cord-005453-4057qib7 10256 44 2 2 CD cord-005453-4057qib7 10256 45 pts pt NNS cord-005453-4057qib7 10256 46 , , , cord-005453-4057qib7 10256 47 β β NN cord-005453-4057qib7 10256 48 - - HYPH cord-005453-4057qib7 10256 49 thalassemia thalassemia NN cord-005453-4057qib7 10256 50 : : : cord-005453-4057qib7 10256 51 1 1 CD cord-005453-4057qib7 10256 52 pt pt NN cord-005453-4057qib7 10256 53 ) ) -RRB- cord-005453-4057qib7 10256 54 , , , cord-005453-4057qib7 10256 55 with with IN cord-005453-4057qib7 10256 56 a a DT cord-005453-4057qib7 10256 57 median median JJ cord-005453-4057qib7 10256 58 age age NN cord-005453-4057qib7 10256 59 of of IN cord-005453-4057qib7 10256 60 30 30 CD cord-005453-4057qib7 10256 61 years year NNS cord-005453-4057qib7 10256 62 ( ( -LRB- cord-005453-4057qib7 10256 63 4 4 CD cord-005453-4057qib7 10256 64 - - SYM cord-005453-4057qib7 10256 65 54 54 CD cord-005453-4057qib7 10256 66 ) ) -RRB- cord-005453-4057qib7 10256 67 , , , cord-005453-4057qib7 10256 68 sex sex NN cord-005453-4057qib7 10256 69 ratio ratio NN cord-005453-4057qib7 10256 70 ( ( -LRB- cord-005453-4057qib7 10256 71 M M NNP cord-005453-4057qib7 10256 72 / / SYM cord-005453-4057qib7 10256 73 F F NNP cord-005453-4057qib7 10256 74 ) ) -RRB- cord-005453-4057qib7 10256 75 of of IN cord-005453-4057qib7 10256 76 1.75 1.75 CD cord-005453-4057qib7 10256 77 . . . cord-005453-4057qib7 10257 1 Allo Allo NNP cord-005453-4057qib7 10257 2 - - HYPH cord-005453-4057qib7 10257 3 HSCT HSCT NNP cord-005453-4057qib7 10257 4 done do VBN cord-005453-4057qib7 10257 5 with with IN cord-005453-4057qib7 10257 6 sibling sibling NN cord-005453-4057qib7 10257 7 donors donor NNS cord-005453-4057qib7 10257 8 : : : cord-005453-4057qib7 10257 9 51 51 CD cord-005453-4057qib7 10257 10 pts pt NNS cord-005453-4057qib7 10257 11 , , , cord-005453-4057qib7 10257 12 Haplo Haplo NNP cord-005453-4057qib7 10257 13 - - HYPH cord-005453-4057qib7 10257 14 identical identical JJ cord-005453-4057qib7 10257 15 donors donor NNS cord-005453-4057qib7 10257 16 : : : cord-005453-4057qib7 10257 17 14 14 CD cord-005453-4057qib7 10257 18 pts pt NNS cord-005453-4057qib7 10257 19 and and CC cord-005453-4057qib7 10257 20 Pheno Pheno NNP cord-005453-4057qib7 10257 21 - - HYPH cord-005453-4057qib7 10257 22 identical identical JJ cord-005453-4057qib7 10257 23 donor donor NN cord-005453-4057qib7 10257 24 : : : cord-005453-4057qib7 10257 25 1 1 CD cord-005453-4057qib7 10257 26 pt pt NN cord-005453-4057qib7 10257 27 . . . cord-005453-4057qib7 10258 1 All all DT cord-005453-4057qib7 10258 2 pts pt NNS cord-005453-4057qib7 10258 3 were be VBD cord-005453-4057qib7 10258 4 treated treat VBN cord-005453-4057qib7 10258 5 by by IN cord-005453-4057qib7 10258 6 chemotherapy chemotherapy NN cord-005453-4057qib7 10258 7 alone alone RB cord-005453-4057qib7 10258 8 with with IN cord-005453-4057qib7 10258 9 myéloablative myéloablative JJ cord-005453-4057qib7 10258 10 conditioning conditioning NN cord-005453-4057qib7 10258 11 ( ( -LRB- cord-005453-4057qib7 10258 12 MAC MAC NNP cord-005453-4057qib7 10258 13 ) ) -RRB- cord-005453-4057qib7 10258 14 in in IN cord-005453-4057qib7 10258 15 41 41 CD cord-005453-4057qib7 10258 16 pts pt NNS cord-005453-4057qib7 10258 17 and and CC cord-005453-4057qib7 10258 18 reduced reduce VBN cord-005453-4057qib7 10258 19 intensity intensity NN cord-005453-4057qib7 10258 20 ( ( -LRB- cord-005453-4057qib7 10258 21 RIC RIC NNP cord-005453-4057qib7 10258 22 ) ) -RRB- cord-005453-4057qib7 10258 23 in in IN cord-005453-4057qib7 10258 24 25 25 CD cord-005453-4057qib7 10258 25 pts pt NNS cord-005453-4057qib7 10258 26 . . . cord-005453-4057qib7 10259 1 All all DT cord-005453-4057qib7 10259 2 pts pt NNS cord-005453-4057qib7 10259 3 received receive VBD cord-005453-4057qib7 10259 4 peripheral peripheral JJ cord-005453-4057qib7 10259 5 blood blood NN cord-005453-4057qib7 10259 6 stem stem NN cord-005453-4057qib7 10259 7 cells cell NNS cord-005453-4057qib7 10259 8 with with IN cord-005453-4057qib7 10259 9 an an DT cord-005453-4057qib7 10259 10 average average JJ cord-005453-4057qib7 10259 11 rate rate NN cord-005453-4057qib7 10259 12 of of IN cord-005453-4057qib7 10259 13 CD34 CD34 NNP cord-005453-4057qib7 10259 14 + + CC cord-005453-4057qib7 10259 15 cells cell NNS cord-005453-4057qib7 10259 16 : : : cord-005453-4057qib7 10259 17 7 7 CD cord-005453-4057qib7 10259 18 , , , cord-005453-4057qib7 10259 19 8.10 8.10 CD cord-005453-4057qib7 10259 20 6 6 CD cord-005453-4057qib7 10260 1 /kg /kg NFP cord-005453-4057qib7 10260 2 ( ( -LRB- cord-005453-4057qib7 10260 3 3.4 3.4 CD cord-005453-4057qib7 10260 4 - - SYM cord-005453-4057qib7 10260 5 12.7 12.7 CD cord-005453-4057qib7 10260 6 ) ) -RRB- cord-005453-4057qib7 10260 7 . . . cord-005453-4057qib7 10261 1 Additional additional JJ cord-005453-4057qib7 10261 2 bone bone NN cord-005453-4057qib7 10261 3 marrow marrow NN cord-005453-4057qib7 10261 4 graft graft NN cord-005453-4057qib7 10261 5 was be VBD cord-005453-4057qib7 10261 6 used use VBN cord-005453-4057qib7 10261 7 in in IN cord-005453-4057qib7 10261 8 7 7 CD cord-005453-4057qib7 10261 9 pts pt NNS cord-005453-4057qib7 10261 10 that that WDT cord-005453-4057qib7 10261 11 received receive VBD cord-005453-4057qib7 10261 12 a a DT cord-005453-4057qib7 10261 13 haploidentical haploidentical JJ cord-005453-4057qib7 10261 14 graft graft NN cord-005453-4057qib7 10261 15 without without IN cord-005453-4057qib7 10261 16 PT PT NNP cord-005453-4057qib7 10261 17 - - HYPH cord-005453-4057qib7 10261 18 cy cy NNP cord-005453-4057qib7 10261 19 . . . cord-005453-4057qib7 10262 1 GVH GVH NNP cord-005453-4057qib7 10262 2 prophylaxis prophylaxis NN cord-005453-4057qib7 10262 3 associated associate VBD cord-005453-4057qib7 10262 4 cyclosporine cyclosporine NN cord-005453-4057qib7 10262 5 ( ( -LRB- cord-005453-4057qib7 10262 6 cSA cSA NNP cord-005453-4057qib7 10262 7 ) ) -RRB- cord-005453-4057qib7 10262 8 and and CC cord-005453-4057qib7 10262 9 methotrexate methotrexate NNP cord-005453-4057qib7 10262 10 ( ( -LRB- cord-005453-4057qib7 10262 11 sibling sibling NN cord-005453-4057qib7 10262 12 and and CC cord-005453-4057qib7 10262 13 phenoidentical phenoidentical JJ cord-005453-4057qib7 10262 14 ) ) -RRB- cord-005453-4057qib7 10262 15 ; ; : cord-005453-4057qib7 10262 16 cSA csa XX cord-005453-4057qib7 10262 17 - - HYPH cord-005453-4057qib7 10262 18 MTX MTX NNP cord-005453-4057qib7 10262 19 - - HYPH cord-005453-4057qib7 10262 20 MMF mmf NN cord-005453-4057qib7 10262 21 or or CC cord-005453-4057qib7 10262 22 cSA csa NN cord-005453-4057qib7 10262 23 - - HYPH cord-005453-4057qib7 10262 24 MTX MTX NNP cord-005453-4057qib7 10262 25 - - HYPH cord-005453-4057qib7 10262 26 Cyclophosphamid Cyclophosphamid NNP cord-005453-4057qib7 10262 27 ( ( -LRB- cord-005453-4057qib7 10262 28 haplo haplo NN cord-005453-4057qib7 10262 29 - - HYPH cord-005453-4057qib7 10262 30 identical identical JJ cord-005453-4057qib7 10262 31 ) ) -RRB- cord-005453-4057qib7 10262 32 . . . cord-005453-4057qib7 10263 1 Before before IN cord-005453-4057qib7 10263 2 transplantation transplantation NN cord-005453-4057qib7 10263 3 , , , cord-005453-4057qib7 10263 4 donor donor NN cord-005453-4057qib7 10263 5 / / SYM cord-005453-4057qib7 10263 6 recipient recipient NN cord-005453-4057qib7 10263 7 pair pair NN cord-005453-4057qib7 10263 8 is be VBZ cord-005453-4057qib7 10263 9 at at IN cord-005453-4057qib7 10263 10 high high JJ cord-005453-4057qib7 10263 11 risk risk NN cord-005453-4057qib7 10263 12 reactivation reactivation NN cord-005453-4057qib7 10263 13 in in IN cord-005453-4057qib7 10263 14 65 65 CD cord-005453-4057qib7 10263 15 pts pts NN cord-005453-4057qib7 10263 16 ( ( -LRB- cord-005453-4057qib7 10263 17 98.4 98.4 CD cord-005453-4057qib7 10263 18 % % NN cord-005453-4057qib7 10263 19 ) ) -RRB- cord-005453-4057qib7 10263 20 . . . cord-005453-4057qib7 10264 1 Detection detection NN cord-005453-4057qib7 10264 2 of of IN cord-005453-4057qib7 10264 3 CMV CMV NNP cord-005453-4057qib7 10264 4 reactivation reactivation NN cord-005453-4057qib7 10264 5 done do VBN cord-005453-4057qib7 10264 6 by by IN cord-005453-4057qib7 10264 7 Antigenaemia Antigenaemia NNP cord-005453-4057qib7 10264 8 pp65 pp65 NNP cord-005453-4057qib7 10264 9 or or CC cord-005453-4057qib7 10264 10 by by IN cord-005453-4057qib7 10264 11 quantitative quantitative JJ cord-005453-4057qib7 10264 12 PCR PCR NNP cord-005453-4057qib7 10264 13 weekly weekly NN cord-005453-4057qib7 10264 14 for for IN cord-005453-4057qib7 10264 15 the the DT cord-005453-4057qib7 10264 16 first first JJ cord-005453-4057qib7 10264 17 3 3 CD cord-005453-4057qib7 10264 18 months month NNS cord-005453-4057qib7 10264 19 and and CC cord-005453-4057qib7 10264 20 during during IN cord-005453-4057qib7 10264 21 an an DT cord-005453-4057qib7 10264 22 IS IS NNP cord-005453-4057qib7 10264 23 treatment treatment NN cord-005453-4057qib7 10264 24 for for IN cord-005453-4057qib7 10264 25 acute acute JJ cord-005453-4057qib7 10264 26 or or CC cord-005453-4057qib7 10264 27 chronic chronic JJ cord-005453-4057qib7 10264 28 GVHD GVHD NNP cord-005453-4057qib7 10264 29 . . . cord-005453-4057qib7 10265 1 Pre pre JJ cord-005453-4057qib7 10265 2 - - JJ cord-005453-4057qib7 10265 3 emptive emptive JJ cord-005453-4057qib7 10265 4 therapy therapy NN cord-005453-4057qib7 10265 5 is be VBZ cord-005453-4057qib7 10265 6 initiated initiate VBN cord-005453-4057qib7 10265 7 by by IN cord-005453-4057qib7 10265 8 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 10265 9 as as RB cord-005453-4057qib7 10265 10 soon soon RB cord-005453-4057qib7 10265 11 as as IN cord-005453-4057qib7 10265 12 positivity positivity NN cord-005453-4057qib7 10265 13 of of IN cord-005453-4057qib7 10265 14 antigenaemia antigenaemia NN cord-005453-4057qib7 10265 15 or or CC cord-005453-4057qib7 10265 16 increased increase VBN cord-005453-4057qib7 10265 17 viral viral JJ cord-005453-4057qib7 10265 18 load load NN cord-005453-4057qib7 10265 19 in in IN cord-005453-4057qib7 10265 20 PCR PCR NNP cord-005453-4057qib7 10265 21 . . . cord-005453-4057qib7 10266 1 Results result NNS cord-005453-4057qib7 10266 2 : : : cord-005453-4057qib7 10267 1 A a DT cord-005453-4057qib7 10267 2 first first JJ cord-005453-4057qib7 10267 3 reactivation reactivation NN cord-005453-4057qib7 10267 4 occurred occur VBD cord-005453-4057qib7 10267 5 on on IN cord-005453-4057qib7 10267 6 average average JJ cord-005453-4057qib7 10267 7 day day NN cord-005453-4057qib7 10267 8 44 44 CD cord-005453-4057qib7 10267 9 ( ( -LRB- cord-005453-4057qib7 10267 10 16 16 CD cord-005453-4057qib7 10267 11 - - SYM cord-005453-4057qib7 10267 12 83 83 CD cord-005453-4057qib7 10267 13 ) ) -RRB- cord-005453-4057qib7 10267 14 in in IN cord-005453-4057qib7 10267 15 66 66 CD cord-005453-4057qib7 10267 16 pts pt NNS cord-005453-4057qib7 10267 17 ( ( -LRB- cord-005453-4057qib7 10267 18 26.82 26.82 CD cord-005453-4057qib7 10267 19 % % NN cord-005453-4057qib7 10267 20 ) ) -RRB- cord-005453-4057qib7 10267 21 of of IN cord-005453-4057qib7 10267 22 which which WDT cord-005453-4057qib7 10267 23 32 32 CD cord-005453-4057qib7 10267 24 pts pt NNS cord-005453-4057qib7 10267 25 under under IN cord-005453-4057qib7 10267 26 Corticotherapy Corticotherapy NNP cord-005453-4057qib7 10267 27 for for IN cord-005453-4057qib7 10267 28 acute acute JJ cord-005453-4057qib7 10267 29 GVHD GVHD NNP cord-005453-4057qib7 10267 30 ( ( -LRB- cord-005453-4057qib7 10267 31 27 27 CD cord-005453-4057qib7 10267 32 pts pt NNS cord-005453-4057qib7 10267 33 ) ) -RRB- cord-005453-4057qib7 10267 34 , , , cord-005453-4057qib7 10267 35 Thrombotic Thrombotic NNP cord-005453-4057qib7 10267 36 Micro Micro NNP cord-005453-4057qib7 10267 37 - - HYPH cord-005453-4057qib7 10267 38 Angiopathy Angiopathy NNP cord-005453-4057qib7 10267 39 ( ( -LRB- cord-005453-4057qib7 10267 40 1 1 CD cord-005453-4057qib7 10267 41 pt pt NN cord-005453-4057qib7 10267 42 ) ) -RRB- cord-005453-4057qib7 10267 43 and and CC cord-005453-4057qib7 10267 44 renal renal JJ cord-005453-4057qib7 10267 45 failure failure NN cord-005453-4057qib7 10267 46 ( ( -LRB- cord-005453-4057qib7 10267 47 4 4 CD cord-005453-4057qib7 10267 48 pts pts CD cord-005453-4057qib7 10267 49 ) ) -RRB- cord-005453-4057qib7 10267 50 or or CC cord-005453-4057qib7 10267 51 due due IN cord-005453-4057qib7 10267 52 to to IN cord-005453-4057qib7 10267 53 a a DT cord-005453-4057qib7 10267 54 reinforced reinforce VBN cord-005453-4057qib7 10267 55 IS be VBZ cord-005453-4057qib7 10267 56 for for IN cord-005453-4057qib7 10267 57 Haplo Haplo NNP cord-005453-4057qib7 10267 58 - - HYPH cord-005453-4057qib7 10267 59 identical identical JJ cord-005453-4057qib7 10267 60 transplantation transplantation NN cord-005453-4057qib7 10267 61 ( ( -LRB- cord-005453-4057qib7 10267 62 5 5 CD cord-005453-4057qib7 10267 63 pts pts CD cord-005453-4057qib7 10267 64 ) ) -RRB- cord-005453-4057qib7 10267 65 . . . cord-005453-4057qib7 10268 1 One one CD cord-005453-4057qib7 10268 2 pt pt NN cord-005453-4057qib7 10268 3 with with IN cord-005453-4057qib7 10268 4 chronic chronic JJ cord-005453-4057qib7 10268 5 GVHD GVHD NNP cord-005453-4057qib7 10268 6 presented present VBD cord-005453-4057qib7 10268 7 a a DT cord-005453-4057qib7 10268 8 late late JJ cord-005453-4057qib7 10268 9 reactivation reactivation NN cord-005453-4057qib7 10268 10 18 18 CD cord-005453-4057qib7 10268 11 months month NNS cord-005453-4057qib7 10268 12 after after IN cord-005453-4057qib7 10268 13 transplant transplant NN cord-005453-4057qib7 10268 14 . . . cord-005453-4057qib7 10269 1 Twenty twenty CD cord-005453-4057qib7 10269 2 pts pt NNS cord-005453-4057qib7 10269 3 presented present VBD cord-005453-4057qib7 10269 4 a a DT cord-005453-4057qib7 10269 5 2 2 CD cord-005453-4057qib7 10269 6 nd nd NNP cord-005453-4057qib7 10269 7 reactivation reactivation NN cord-005453-4057qib7 10269 8 on on IN cord-005453-4057qib7 10269 9 average average JJ cord-005453-4057qib7 10269 10 day day NN cord-005453-4057qib7 10269 11 135 135 CD cord-005453-4057qib7 10269 12 ( ( -LRB- cord-005453-4057qib7 10269 13 106 106 CD cord-005453-4057qib7 10269 14 - - SYM cord-005453-4057qib7 10269 15 180 180 CD cord-005453-4057qib7 10269 16 ) ) -RRB- cord-005453-4057qib7 10269 17 and and CC cord-005453-4057qib7 10269 18 8 8 CD cord-005453-4057qib7 10269 19 pts pt NNS cord-005453-4057qib7 10269 20 a a DT cord-005453-4057qib7 10269 21 3 3 CD cord-005453-4057qib7 10269 22 rd rd NN cord-005453-4057qib7 10269 23 reactivation reactivation NN cord-005453-4057qib7 10269 24 on on IN cord-005453-4057qib7 10269 25 average average JJ cord-005453-4057qib7 10269 26 day day NN cord-005453-4057qib7 10269 27 136 136 CD cord-005453-4057qib7 10269 28 ( ( -LRB- cord-005453-4057qib7 10269 29 130 130 CD cord-005453-4057qib7 10269 30 - - SYM cord-005453-4057qib7 10269 31 143 143 CD cord-005453-4057qib7 10269 32 ) ) -RRB- cord-005453-4057qib7 10269 33 . . . cord-005453-4057qib7 10270 1 Pre pre JJ cord-005453-4057qib7 10270 2 - - JJ cord-005453-4057qib7 10270 3 emptive emptive JJ cord-005453-4057qib7 10270 4 treatment treatment NN cord-005453-4057qib7 10270 5 is be VBZ cord-005453-4057qib7 10270 6 introduced introduce VBN cord-005453-4057qib7 10270 7 in in IN cord-005453-4057qib7 10270 8 the the DT cord-005453-4057qib7 10270 9 first first JJ cord-005453-4057qib7 10270 10 episode episode NN cord-005453-4057qib7 10270 11 by by IN cord-005453-4057qib7 10270 12 a a DT cord-005453-4057qib7 10270 13 viral viral JJ cord-005453-4057qib7 10270 14 DNA dna NN cord-005453-4057qib7 10270 15 polymerase polymerase NN cord-005453-4057qib7 10270 16 inhibitor inhibitor NN cord-005453-4057qib7 10270 17 ( ( -LRB- cord-005453-4057qib7 10270 18 Ganciclovir ganciclovir NN cord-005453-4057qib7 10270 19 : : : cord-005453-4057qib7 10270 20 22 22 CD cord-005453-4057qib7 10270 21 pts pt NNS cord-005453-4057qib7 10270 22 ; ; : cord-005453-4057qib7 10270 23 Valganciclovir Valganciclovir NNP cord-005453-4057qib7 10270 24 : : : cord-005453-4057qib7 10270 25 43 43 CD cord-005453-4057qib7 10270 26 pts pt NNS cord-005453-4057qib7 10270 27 , , , cord-005453-4057qib7 10270 28 Foscarnet foscarnet NN cord-005453-4057qib7 10270 29 : : : cord-005453-4057qib7 10270 30 1 1 CD cord-005453-4057qib7 10270 31 pt pt NN cord-005453-4057qib7 10270 32 ) ) -RRB- cord-005453-4057qib7 10270 33 . . . cord-005453-4057qib7 10271 1 The the DT cord-005453-4057qib7 10271 2 negativity negativity NN cord-005453-4057qib7 10271 3 of of IN cord-005453-4057qib7 10271 4 antigenaemia antigenaemia NN cord-005453-4057qib7 10271 5 is be VBZ cord-005453-4057qib7 10271 6 observed observe VBN cord-005453-4057qib7 10271 7 on on IN cord-005453-4057qib7 10271 8 average average JJ cord-005453-4057qib7 10271 9 at at IN cord-005453-4057qib7 10271 10 5 5 CD cord-005453-4057qib7 10271 11 days day NNS cord-005453-4057qib7 10271 12 of of IN cord-005453-4057qib7 10271 13 treatment treatment NN cord-005453-4057qib7 10271 14 ( ( -LRB- cord-005453-4057qib7 10271 15 3 3 CD cord-005453-4057qib7 10271 16 ) ) -RRB- cord-005453-4057qib7 10271 17 ( ( -LRB- cord-005453-4057qib7 10271 18 4 4 LS cord-005453-4057qib7 10271 19 ) ) -RRB- cord-005453-4057qib7 10271 20 ( ( -LRB- cord-005453-4057qib7 10271 21 5 5 LS cord-005453-4057qib7 10271 22 ) ) -RRB- cord-005453-4057qib7 10271 23 ( ( -LRB- cord-005453-4057qib7 10271 24 6 6 LS cord-005453-4057qib7 10271 25 ) ) -RRB- cord-005453-4057qib7 10271 26 ( ( -LRB- cord-005453-4057qib7 10271 27 7 7 CD cord-005453-4057qib7 10271 28 ) ) -RRB- cord-005453-4057qib7 10271 29 . . . cord-005453-4057qib7 10272 1 Second second JJ cord-005453-4057qib7 10272 2 line line NN cord-005453-4057qib7 10272 3 treatment treatment NN cord-005453-4057qib7 10272 4 was be VBD cord-005453-4057qib7 10272 5 required require VBN cord-005453-4057qib7 10272 6 in in IN cord-005453-4057qib7 10272 7 14 14 CD cord-005453-4057qib7 10272 8 pts pt NNS cord-005453-4057qib7 10272 9 ( ( -LRB- cord-005453-4057qib7 10272 10 22 22 CD cord-005453-4057qib7 10272 11 % % NN cord-005453-4057qib7 10272 12 ) ) -RRB- cord-005453-4057qib7 10272 13 due due IN cord-005453-4057qib7 10272 14 to to IN cord-005453-4057qib7 10272 15 resistance resistance NN cord-005453-4057qib7 10272 16 ( ( -LRB- cord-005453-4057qib7 10272 17 12 12 CD cord-005453-4057qib7 10272 18 pts pt NNS cord-005453-4057qib7 10272 19 ) ) -RRB- cord-005453-4057qib7 10272 20 , , , cord-005453-4057qib7 10272 21 severe severe JJ cord-005453-4057qib7 10272 22 cytopenia cytopenia NNP cord-005453-4057qib7 10272 23 ( ( -LRB- cord-005453-4057qib7 10272 24 1pt 1pt NNP cord-005453-4057qib7 10272 25 ) ) -RRB- cord-005453-4057qib7 10272 26 or or CC cord-005453-4057qib7 10272 27 renal renal JJ cord-005453-4057qib7 10272 28 failure failure NN cord-005453-4057qib7 10272 29 ( ( -LRB- cord-005453-4057qib7 10272 30 1 1 CD cord-005453-4057qib7 10272 31 pt pt NN cord-005453-4057qib7 10272 32 ) ) -RRB- cord-005453-4057qib7 10272 33 . . . cord-005453-4057qib7 10273 1 The the DT cord-005453-4057qib7 10273 2 onset onset NN cord-005453-4057qib7 10273 3 of of IN cord-005453-4057qib7 10273 4 severe severe JJ cord-005453-4057qib7 10273 5 cytopenia cytopenia NNS cord-005453-4057qib7 10273 6 imposed impose VBD cord-005453-4057qib7 10273 7 a a DT cord-005453-4057qib7 10273 8 dose dose JJ cord-005453-4057qib7 10273 9 reduction reduction NN cord-005453-4057qib7 10273 10 ( ( -LRB- cord-005453-4057qib7 10273 11 4 4 CD cord-005453-4057qib7 10273 12 pts pts CD cord-005453-4057qib7 10273 13 ) ) -RRB- cord-005453-4057qib7 10273 14 or or CC cord-005453-4057qib7 10273 15 a a DT cord-005453-4057qib7 10273 16 therapeutic therapeutic JJ cord-005453-4057qib7 10273 17 stop stop NN cord-005453-4057qib7 10273 18 ( ( -LRB- cord-005453-4057qib7 10273 19 6 6 CD cord-005453-4057qib7 10273 20 pts pts CD cord-005453-4057qib7 10273 21 ) ) -RRB- cord-005453-4057qib7 10273 22 before before IN cord-005453-4057qib7 10273 23 15 15 CD cord-005453-4057qib7 10273 24 days day NNS cord-005453-4057qib7 10273 25 . . . cord-005453-4057qib7 10274 1 Two two CD cord-005453-4057qib7 10274 2 pts pt NNS cord-005453-4057qib7 10274 3 received receive VBD cord-005453-4057qib7 10274 4 additional additional JJ cord-005453-4057qib7 10274 5 maintenance maintenance NN cord-005453-4057qib7 10274 6 treatment treatment NN cord-005453-4057qib7 10274 7 for for IN cord-005453-4057qib7 10274 8 negativation negativation NN cord-005453-4057qib7 10274 9 delay delay NN cord-005453-4057qib7 10274 10 . . . cord-005453-4057qib7 10275 1 Three three CD cord-005453-4057qib7 10275 2 pts pt NNS cord-005453-4057qib7 10275 3 ( ( -LRB- cord-005453-4057qib7 10275 4 4.5 4.5 CD cord-005453-4057qib7 10275 5 % % NN cord-005453-4057qib7 10275 6 ) ) -RRB- cord-005453-4057qib7 10275 7 died die VBD cord-005453-4057qib7 10275 8 from from IN cord-005453-4057qib7 10275 9 CMV CMV NNP cord-005453-4057qib7 10275 10 infections infection NNS cord-005453-4057qib7 10275 11 resistant resistant JJ cord-005453-4057qib7 10275 12 to to IN cord-005453-4057qib7 10275 13 antiviral antiviral JJ cord-005453-4057qib7 10275 14 treatment treatment NN cord-005453-4057qib7 10276 1 ( ( -LRB- cord-005453-4057qib7 10276 2 pneumonia pneumonia NN cord-005453-4057qib7 10276 3 : : : cord-005453-4057qib7 10276 4 2 2 CD cord-005453-4057qib7 10276 5 , , , cord-005453-4057qib7 10276 6 Colitis colitis NN cord-005453-4057qib7 10276 7 : : : cord-005453-4057qib7 10276 8 1 1 CD cord-005453-4057qib7 10276 9 ) ) -RRB- cord-005453-4057qib7 10276 10 . . . cord-005453-4057qib7 10277 1 Conclusions conclusion NNS cord-005453-4057qib7 10277 2 : : : cord-005453-4057qib7 10278 1 CMV CMV NNP cord-005453-4057qib7 10278 2 infection infection NN cord-005453-4057qib7 10278 3 is be VBZ cord-005453-4057qib7 10278 4 a a DT cord-005453-4057qib7 10278 5 serious serious JJ cord-005453-4057qib7 10278 6 complication complication NN cord-005453-4057qib7 10278 7 after after IN cord-005453-4057qib7 10278 8 allo allo NN cord-005453-4057qib7 10278 9 - - HYPH cord-005453-4057qib7 10278 10 HSCT HSCT NNP cord-005453-4057qib7 10278 11 . . . cord-005453-4057qib7 10279 1 In in IN cord-005453-4057qib7 10279 2 the the DT cord-005453-4057qib7 10279 3 absence absence NN cord-005453-4057qib7 10279 4 of of IN cord-005453-4057qib7 10279 5 vaccination vaccination NN cord-005453-4057qib7 10279 6 , , , cord-005453-4057qib7 10279 7 the the DT cord-005453-4057qib7 10279 8 systematic systematic JJ cord-005453-4057qib7 10279 9 monitoring monitoring NN cord-005453-4057qib7 10279 10 for for IN cord-005453-4057qib7 10279 11 CMV CMV NNP cord-005453-4057qib7 10279 12 reactivation reactivation NN cord-005453-4057qib7 10279 13 is be VBZ cord-005453-4057qib7 10279 14 strongly strongly RB cord-005453-4057qib7 10279 15 recommended recommend VBN cord-005453-4057qib7 10279 16 for for IN cord-005453-4057qib7 10279 17 the the DT cord-005453-4057qib7 10279 18 establishment establishment NN cord-005453-4057qib7 10279 19 of of IN cord-005453-4057qib7 10279 20 a a DT cord-005453-4057qib7 10279 21 rapid rapid JJ cord-005453-4057qib7 10279 22 and and CC cord-005453-4057qib7 10279 23 effective effective JJ cord-005453-4057qib7 10279 24 preemptive preemptive JJ cord-005453-4057qib7 10279 25 treatment treatment NN cord-005453-4057qib7 10279 26 . . . cord-005453-4057qib7 10280 1 Disclosure disclosure NN cord-005453-4057qib7 10280 2 : : : cord-005453-4057qib7 10280 3 Nothing nothing NN cord-005453-4057qib7 10280 4 to to TO cord-005453-4057qib7 10280 5 declare declare VB cord-005453-4057qib7 10280 6 P456 P456 NNP cord-005453-4057qib7 10280 7 Abstract Abstract NNP cord-005453-4057qib7 10280 8 withdrawn withdraw VBN cord-005453-4057qib7 10280 9 . . . cord-005453-4057qib7 10281 1 Results result NNS cord-005453-4057qib7 10281 2 : : : cord-005453-4057qib7 10282 1 In in IN cord-005453-4057qib7 10282 2 transplanted transplanted JJ cord-005453-4057qib7 10282 3 group group NN cord-005453-4057qib7 10282 4 , , , cord-005453-4057qib7 10282 5 episodes episode NNS cord-005453-4057qib7 10282 6 of of IN cord-005453-4057qib7 10282 7 BKV BKV NNP cord-005453-4057qib7 10282 8 reactivation reactivation NN cord-005453-4057qib7 10282 9 occurred occur VBD cord-005453-4057qib7 10282 10 in in IN cord-005453-4057qib7 10282 11 54 54 CD cord-005453-4057qib7 10282 12 patients patient NNS cord-005453-4057qib7 10282 13 ( ( -LRB- cord-005453-4057qib7 10282 14 42 42 CD cord-005453-4057qib7 10282 15 % % NN cord-005453-4057qib7 10282 16 ) ) -RRB- cord-005453-4057qib7 10282 17 . . . cord-005453-4057qib7 10283 1 In in IN cord-005453-4057qib7 10283 2 26 26 CD cord-005453-4057qib7 10283 3 cases case NNS cord-005453-4057qib7 10283 4 only only RB cord-005453-4057qib7 10283 5 urine urine NN cord-005453-4057qib7 10283 6 colonization colonization NN cord-005453-4057qib7 10283 7 ( ( -LRB- cord-005453-4057qib7 10283 8 C C NNP cord-005453-4057qib7 10283 9 ) ) -RRB- cord-005453-4057qib7 10283 10 found find VBN cord-005453-4057qib7 10283 11 before before IN cord-005453-4057qib7 10283 12 HSCT HSCT NNP cord-005453-4057qib7 10283 13 . . . cord-005453-4057qib7 10284 1 In in IN cord-005453-4057qib7 10284 2 this this DT cord-005453-4057qib7 10284 3 group group NN cord-005453-4057qib7 10284 4 in in IN cord-005453-4057qib7 10284 5 10 10 CD cord-005453-4057qib7 10284 6 patients patient NNS cord-005453-4057qib7 10284 7 ( ( -LRB- cord-005453-4057qib7 10284 8 39 39 CD cord-005453-4057qib7 10284 9 % % NN cord-005453-4057qib7 10284 10 ) ) -RRB- cord-005453-4057qib7 10285 1 virus virus NN cord-005453-4057qib7 10285 2 was be VBD cord-005453-4057qib7 10285 3 transmitted transmit VBN cord-005453-4057qib7 10285 4 from from IN cord-005453-4057qib7 10285 5 urine urine NN cord-005453-4057qib7 10285 6 to to IN cord-005453-4057qib7 10285 7 the the DT cord-005453-4057qib7 10285 8 blood blood NN cord-005453-4057qib7 10285 9 ( ( -LRB- cord-005453-4057qib7 10285 10 B b NN cord-005453-4057qib7 10285 11 ) ) -RRB- cord-005453-4057qib7 10285 12 . . . cord-005453-4057qib7 10286 1 Dysuria Dysuria NNP cord-005453-4057qib7 10286 2 and/or and/or CC cord-005453-4057qib7 10286 3 HC HC NNP cord-005453-4057qib7 10286 4 were be VBD cord-005453-4057qib7 10286 5 observed observe VBN cord-005453-4057qib7 10286 6 in in IN cord-005453-4057qib7 10286 7 4/26 4/26 CD cord-005453-4057qib7 10286 8 ( ( -LRB- cord-005453-4057qib7 10286 9 15 15 CD cord-005453-4057qib7 10286 10 % % NN cord-005453-4057qib7 10286 11 ) ) -RRB- cord-005453-4057qib7 10286 12 patients patient NNS cord-005453-4057qib7 10286 13 . . . cord-005453-4057qib7 10287 1 All all DT cord-005453-4057qib7 10287 2 of of IN cord-005453-4057qib7 10287 3 them -PRON- PRP cord-005453-4057qib7 10287 4 ( ( -LRB- cord-005453-4057qib7 10287 5 100 100 CD cord-005453-4057qib7 10287 6 % % NN cord-005453-4057qib7 10287 7 ) ) -RRB- cord-005453-4057qib7 10287 8 had have VBD cord-005453-4057qib7 10287 9 urine urine NN cord-005453-4057qib7 10287 10 and and CC cord-005453-4057qib7 10287 11 serum serum NN cord-005453-4057qib7 10287 12 involvement involvement NN cord-005453-4057qib7 10287 13 . . . cord-005453-4057qib7 10288 1 In in IN cord-005453-4057qib7 10288 2 28 28 CD cord-005453-4057qib7 10288 3 cases case NNS cord-005453-4057qib7 10288 4 BKV BKV NNP cord-005453-4057qib7 10288 5 replication replication NN cord-005453-4057qib7 10288 6 was be VBD cord-005453-4057qib7 10288 7 found find VBN cord-005453-4057qib7 10288 8 after after IN cord-005453-4057qib7 10288 9 HSCT HSCT NNP cord-005453-4057qib7 10288 10 ( ( -LRB- cord-005453-4057qib7 10289 1 3 3 LS cord-005453-4057qib7 10289 2 -cases -cases : cord-005453-4057qib7 10289 3 detected detect VBN cord-005453-4057qib7 10289 4 in in IN cord-005453-4057qib7 10289 5 urine urine NN cord-005453-4057qib7 10289 6 , , , cord-005453-4057qib7 10289 7 25 25 CD cord-005453-4057qib7 10289 8 cases case NNS cord-005453-4057qib7 10289 9 - - : cord-005453-4057qib7 10289 10 bothserum bothserum NNS cord-005453-4057qib7 10289 11 and and CC cord-005453-4057qib7 10289 12 urine urine NN cord-005453-4057qib7 10289 13 ) ) -RRB- cord-005453-4057qib7 10289 14 . . . cord-005453-4057qib7 10290 1 Dysuric Dysuric NNP cord-005453-4057qib7 10290 2 syndromes syndrome NNS cord-005453-4057qib7 10291 1 and/or and/or CC cord-005453-4057qib7 10291 2 HC HC NNP cord-005453-4057qib7 10291 3 were be VBD cord-005453-4057qib7 10291 4 found find VBN cord-005453-4057qib7 10291 5 in in IN cord-005453-4057qib7 10291 6 5/28 5/28 CD cord-005453-4057qib7 10291 7 of of IN cord-005453-4057qib7 10291 8 cases case NNS cord-005453-4057qib7 10291 9 ( ( -LRB- cord-005453-4057qib7 10292 1 18%)-all 18%)-all CD cord-005453-4057qib7 10292 2 in in IN cord-005453-4057qib7 10292 3 patients patient NNS cord-005453-4057qib7 10292 4 with with IN cord-005453-4057qib7 10292 5 serum serum NN cord-005453-4057qib7 10292 6 and and CC cord-005453-4057qib7 10292 7 urine urine NN cord-005453-4057qib7 10292 8 involvement involvement NN cord-005453-4057qib7 10292 9 . . . cord-005453-4057qib7 10293 1 Urinary urinary JJ cord-005453-4057qib7 10293 2 tract tract NN cord-005453-4057qib7 10293 3 was be VBD cord-005453-4057qib7 10293 4 always always RB cord-005453-4057qib7 10293 5 first first JJ cord-005453-4057qib7 10293 6 location location NN cord-005453-4057qib7 10293 7 of of IN cord-005453-4057qib7 10293 8 the the DT cord-005453-4057qib7 10293 9 virus virus NN cord-005453-4057qib7 10293 10 . . . cord-005453-4057qib7 10294 1 There there EX cord-005453-4057qib7 10294 2 was be VBD cord-005453-4057qib7 10294 3 no no DT cord-005453-4057qib7 10294 4 case case NN cord-005453-4057qib7 10294 5 of of IN cord-005453-4057qib7 10294 6 isolated isolated JJ cord-005453-4057qib7 10294 7 serum serum NN cord-005453-4057qib7 10294 8 reactivation reactivation NN cord-005453-4057qib7 10294 9 . . . cord-005453-4057qib7 10295 1 The the DT cord-005453-4057qib7 10295 2 incidence incidence NN cord-005453-4057qib7 10295 3 of of IN cord-005453-4057qib7 10295 4 BK BK NNP cord-005453-4057qib7 10295 5 infection infection NN cord-005453-4057qib7 10295 6 was be VBD cord-005453-4057qib7 10295 7 higher high JJR cord-005453-4057qib7 10295 8 in in IN cord-005453-4057qib7 10295 9 patients patient NNS cord-005453-4057qib7 10295 10 older old JJR cord-005453-4057qib7 10295 11 than than IN cord-005453-4057qib7 10295 12 > > XX cord-005453-4057qib7 10295 13 5 5 CD cord-005453-4057qib7 10295 14 yrs yrs NN cord-005453-4057qib7 10296 1 ( ( -LRB- cord-005453-4057qib7 10296 2 p p NN cord-005453-4057qib7 10296 3 < < XX cord-005453-4057qib7 10296 4 0.05 0.05 CD cord-005453-4057qib7 10296 5 ) ) -RRB- cord-005453-4057qib7 10296 6 , , , cord-005453-4057qib7 10296 7 transplanted transplant VBN cord-005453-4057qib7 10296 8 from from IN cord-005453-4057qib7 10296 9 family family NN cord-005453-4057qib7 10296 10 donor donor NN cord-005453-4057qib7 10296 11 ( ( -LRB- cord-005453-4057qib7 10296 12 MSD MSD NNP cord-005453-4057qib7 10296 13 ) ) -RRB- cord-005453-4057qib7 10296 14 ( ( -LRB- cord-005453-4057qib7 10296 15 p p NN cord-005453-4057qib7 10296 16 < < XX cord-005453-4057qib7 10296 17 0.05 0.05 CD cord-005453-4057qib7 10296 18 ) ) -RRB- cord-005453-4057qib7 10296 19 . . . cord-005453-4057qib7 10297 1 MUD mud NN cord-005453-4057qib7 10297 2 recipients recipient NNS cord-005453-4057qib7 10297 3 had have VBD cord-005453-4057qib7 10297 4 more more RBR cord-005453-4057qib7 10297 5 often often RB cord-005453-4057qib7 10297 6 both both DT cord-005453-4057qib7 10297 7 serum serum NN cord-005453-4057qib7 10297 8 and and CC cord-005453-4057qib7 10297 9 urine urine NN cord-005453-4057qib7 10297 10 reactivation reactivation NN cord-005453-4057qib7 10297 11 ( ( -LRB- cord-005453-4057qib7 10297 12 p p NN cord-005453-4057qib7 10297 13 < < XX cord-005453-4057qib7 10297 14 0.05 0.05 CD cord-005453-4057qib7 10297 15 ) ) -RRB- cord-005453-4057qib7 10297 16 than than IN cord-005453-4057qib7 10297 17 isolated isolate VBN cord-005453-4057qib7 10297 18 urine urine NN cord-005453-4057qib7 10297 19 involvement involvement NN cord-005453-4057qib7 10297 20 . . . cord-005453-4057qib7 10298 1 Sex sex NN cord-005453-4057qib7 10298 2 , , , cord-005453-4057qib7 10298 3 day day NN cord-005453-4057qib7 10298 4 of of IN cord-005453-4057qib7 10298 5 neutrophil neutrophil NN cord-005453-4057qib7 10298 6 recovery recovery NN cord-005453-4057qib7 10298 7 , , , cord-005453-4057qib7 10298 8 conditioning conditioning NN cord-005453-4057qib7 10298 9 regimen regimen NN cord-005453-4057qib7 10298 10 , , , cord-005453-4057qib7 10298 11 or or CC cord-005453-4057qib7 10298 12 use use NN cord-005453-4057qib7 10298 13 of of IN cord-005453-4057qib7 10298 14 total total JJ cord-005453-4057qib7 10298 15 body body NN cord-005453-4057qib7 10298 16 irradiation irradiation NN cord-005453-4057qib7 10298 17 were be VBD cord-005453-4057qib7 10298 18 not not RB cord-005453-4057qib7 10298 19 significant significant JJ cord-005453-4057qib7 10298 20 risk risk NN cord-005453-4057qib7 10298 21 factors factor NNS cord-005453-4057qib7 10298 22 for for IN cord-005453-4057qib7 10298 23 BKV BKV NNP cord-005453-4057qib7 10298 24 infection infection NN cord-005453-4057qib7 10298 25 , , , cord-005453-4057qib7 10298 26 or or CC cord-005453-4057qib7 10298 27 HC HC NNP cord-005453-4057qib7 10298 28 . . . cord-005453-4057qib7 10299 1 Six six CD cord-005453-4057qib7 10299 2 patients patient NNS cord-005453-4057qib7 10299 3 were be VBD cord-005453-4057qib7 10299 4 treated treat VBN cord-005453-4057qib7 10299 5 with with IN cord-005453-4057qib7 10299 6 Cidofovir Cidofovir NNP cord-005453-4057qib7 10299 7 ( ( -LRB- cord-005453-4057qib7 10299 8 range range NNP cord-005453-4057qib7 10299 9 1 1 CD cord-005453-4057qib7 10299 10 - - SYM cord-005453-4057qib7 10299 11 4 4 CD cord-005453-4057qib7 10299 12 doses dose NNS cord-005453-4057qib7 10299 13 ) ) -RRB- cord-005453-4057qib7 10299 14 with with IN cord-005453-4057qib7 10299 15 good good JJ cord-005453-4057qib7 10299 16 response response NN cord-005453-4057qib7 10299 17 . . . cord-005453-4057qib7 10300 1 There there EX cord-005453-4057qib7 10300 2 was be VBD cord-005453-4057qib7 10300 3 no no DT cord-005453-4057qib7 10300 4 death death NN cord-005453-4057qib7 10300 5 due due IN cord-005453-4057qib7 10300 6 to to IN cord-005453-4057qib7 10300 7 evident evident JJ cord-005453-4057qib7 10300 8 BKV BKV NNP cord-005453-4057qib7 10300 9 infection infection NN cord-005453-4057qib7 10300 10 . . . cord-005453-4057qib7 10301 1 Conclusions conclusion NNS cord-005453-4057qib7 10301 2 : : : cord-005453-4057qib7 10302 1 BKV BKV NNP cord-005453-4057qib7 10302 2 reactivation reactivation NN cord-005453-4057qib7 10302 3 remains remain VBZ cord-005453-4057qib7 10302 4 one one CD cord-005453-4057qib7 10302 5 of of IN cord-005453-4057qib7 10302 6 the the DT cord-005453-4057qib7 10302 7 most most RBS cord-005453-4057qib7 10302 8 frequent frequent JJ cord-005453-4057qib7 10302 9 infectious infectious JJ cord-005453-4057qib7 10302 10 complication complication NN cord-005453-4057qib7 10302 11 in in IN cord-005453-4057qib7 10302 12 children child NNS cord-005453-4057qib7 10302 13 undergoing undergo VBG cord-005453-4057qib7 10302 14 allogeneic allogeneic IN cord-005453-4057qib7 10302 15 HSCT HSCT NNP cord-005453-4057qib7 10302 16 . . . cord-005453-4057qib7 10303 1 Most Most JJS cord-005453-4057qib7 10303 2 of of IN cord-005453-4057qib7 10303 3 patients patient NNS cord-005453-4057qib7 10303 4 experienced experience VBD cord-005453-4057qib7 10303 5 mild mild JJ cord-005453-4057qib7 10303 6 infection infection NN cord-005453-4057qib7 10303 7 and and CC cord-005453-4057qib7 10303 8 age age NN cord-005453-4057qib7 10303 9 < < XX cord-005453-4057qib7 10303 10 5 5 CD cord-005453-4057qib7 10303 11 years year NNS cord-005453-4057qib7 10303 12 was be VBD cord-005453-4057qib7 10303 13 the the DT cord-005453-4057qib7 10303 14 positive positive JJ cord-005453-4057qib7 10303 15 prognostic prognostic JJ cord-005453-4057qib7 10303 16 factor factor NN cord-005453-4057qib7 10303 17 influencing influence VBG cord-005453-4057qib7 10303 18 its -PRON- PRP$ cord-005453-4057qib7 10303 19 incidence incidence NN cord-005453-4057qib7 10303 20 . . . cord-005453-4057qib7 10304 1 BKV bkv NN cord-005453-4057qib7 10304 2 monitoring monitoring NN cord-005453-4057qib7 10304 3 and and CC cord-005453-4057qib7 10304 4 prompt prompt JJ cord-005453-4057qib7 10304 5 treatment treatment NN cord-005453-4057qib7 10304 6 of of IN cord-005453-4057qib7 10304 7 HC HC NNP cord-005453-4057qib7 10304 8 resulted result VBD cord-005453-4057qib7 10304 9 in in IN cord-005453-4057qib7 10304 10 excellent excellent JJ cord-005453-4057qib7 10304 11 outcome outcome NN cord-005453-4057qib7 10304 12 . . . cord-005453-4057qib7 10305 1 We -PRON- PRP cord-005453-4057qib7 10305 2 observed observe VBD cord-005453-4057qib7 10305 3 surprisingly surprisingly RB cord-005453-4057qib7 10305 4 high high JJ cord-005453-4057qib7 10305 5 rate rate NN cord-005453-4057qib7 10305 6 of of IN cord-005453-4057qib7 10305 7 new new JJ cord-005453-4057qib7 10305 8 BKV BKV NNP cord-005453-4057qib7 10305 9 replication replication NN cord-005453-4057qib7 10305 10 after after IN cord-005453-4057qib7 10305 11 HSCT HSCT NNP cord-005453-4057qib7 10305 12 . . . cord-005453-4057qib7 10306 1 Disclosure disclosure NN cord-005453-4057qib7 10306 2 : : : cord-005453-4057qib7 10306 3 Nothing nothing NN cord-005453-4057qib7 10306 4 to to TO cord-005453-4057qib7 10306 5 declare declare VB cord-005453-4057qib7 10306 6 Background background NN cord-005453-4057qib7 10306 7 : : : cord-005453-4057qib7 10306 8 High high JJ cord-005453-4057qib7 10306 9 - - HYPH cord-005453-4057qib7 10306 10 dose dose NN cord-005453-4057qib7 10306 11 chemotherapy chemotherapy NN cord-005453-4057qib7 10306 12 ( ( -LRB- cord-005453-4057qib7 10306 13 HD HD NNP cord-005453-4057qib7 10306 14 - - HYPH cord-005453-4057qib7 10306 15 CT CT NNP cord-005453-4057qib7 10306 16 ) ) -RRB- cord-005453-4057qib7 10306 17 and and CC cord-005453-4057qib7 10306 18 auto auto NN cord-005453-4057qib7 10306 19 PBSCT PBSCT NNP cord-005453-4057qib7 10306 20 have have VBP cord-005453-4057qib7 10306 21 been be VBN cord-005453-4057qib7 10306 22 the the DT cord-005453-4057qib7 10306 23 standard standard JJ cord-005453-4057qib7 10306 24 therapy therapy NN cord-005453-4057qib7 10306 25 for for IN cord-005453-4057qib7 10306 26 multiple multiple JJ cord-005453-4057qib7 10306 27 myeloma myeloma NN cord-005453-4057qib7 10306 28 ( ( -LRB- cord-005453-4057qib7 10306 29 MM MM NNP cord-005453-4057qib7 10306 30 ) ) -RRB- cord-005453-4057qib7 10306 31 for for IN cord-005453-4057qib7 10306 32 more more JJR cord-005453-4057qib7 10306 33 than than IN cord-005453-4057qib7 10306 34 two two CD cord-005453-4057qib7 10306 35 decades decade NNS cord-005453-4057qib7 10306 36 , , , cord-005453-4057qib7 10306 37 despite despite IN cord-005453-4057qib7 10306 38 a a DT cord-005453-4057qib7 10306 39 wide wide JJ cord-005453-4057qib7 10306 40 range range NN cord-005453-4057qib7 10306 41 of of IN cord-005453-4057qib7 10306 42 new new JJ cord-005453-4057qib7 10306 43 therapeutic therapeutic JJ cord-005453-4057qib7 10306 44 options option NNS cord-005453-4057qib7 10306 45 . . . cord-005453-4057qib7 10307 1 Recurrent recurrent JJ cord-005453-4057qib7 10307 2 / / SYM cord-005453-4057qib7 10307 3 refractory refractory JJ cord-005453-4057qib7 10307 4 malignant malignant JJ cord-005453-4057qib7 10307 5 lymphomas lymphoma NNS cord-005453-4057qib7 10307 6 and and CC cord-005453-4057qib7 10307 7 recurrent recurrent JJ cord-005453-4057qib7 10307 8 / / SYM cord-005453-4057qib7 10307 9 metastatic metastatic JJ cord-005453-4057qib7 10307 10 germ germ NN cord-005453-4057qib7 10307 11 cell cell NN cord-005453-4057qib7 10307 12 tumors tumor NNS cord-005453-4057qib7 10307 13 ( ( -LRB- cord-005453-4057qib7 10307 14 GCT GCT NNP cord-005453-4057qib7 10307 15 ) ) -RRB- cord-005453-4057qib7 10307 16 also also RB cord-005453-4057qib7 10307 17 benefit benefit VBP cord-005453-4057qib7 10307 18 from from IN cord-005453-4057qib7 10307 19 this this DT cord-005453-4057qib7 10307 20 intensive intensive JJ cord-005453-4057qib7 10307 21 therapy therapy NN cord-005453-4057qib7 10307 22 . . . cord-005453-4057qib7 10308 1 In in IN cord-005453-4057qib7 10308 2 comparison comparison NN cord-005453-4057qib7 10308 3 to to IN cord-005453-4057qib7 10308 4 allogeneic allogeneic NN cord-005453-4057qib7 10308 5 transplantation transplantation NN cord-005453-4057qib7 10308 6 , , , cord-005453-4057qib7 10308 7 this this DT cord-005453-4057qib7 10308 8 treatment treatment NN cord-005453-4057qib7 10308 9 is be VBZ cord-005453-4057qib7 10308 10 known know VBN cord-005453-4057qib7 10308 11 for for IN cord-005453-4057qib7 10308 12 lower low JJR cord-005453-4057qib7 10308 13 complication complication NN cord-005453-4057qib7 10308 14 rates rate NNS cord-005453-4057qib7 10308 15 , , , cord-005453-4057qib7 10308 16 e.g. e.g. IN cord-005453-4057qib7 10308 17 infections infection NNS cord-005453-4057qib7 10308 18 . . . cord-005453-4057qib7 10309 1 However however RB cord-005453-4057qib7 10309 2 previous previous JJ cord-005453-4057qib7 10309 3 studies study NNS cord-005453-4057qib7 10309 4 have have VBP cord-005453-4057qib7 10309 5 schown schown NN cord-005453-4057qib7 10309 6 that that IN cord-005453-4057qib7 10309 7 treatment treatment NN cord-005453-4057qib7 10309 8 related relate VBN cord-005453-4057qib7 10309 9 toxicity toxicity NN cord-005453-4057qib7 10309 10 may may MD cord-005453-4057qib7 10309 11 not not RB cord-005453-4057qib7 10309 12 be be VB cord-005453-4057qib7 10309 13 underestimated underestimate VBN cord-005453-4057qib7 10309 14 and and CC cord-005453-4057qib7 10309 15 depending depend VBG cord-005453-4057qib7 10309 16 on on IN cord-005453-4057qib7 10309 17 the the DT cord-005453-4057qib7 10309 18 conditioning conditioning NN cord-005453-4057qib7 10309 19 regimen regimen NN cord-005453-4057qib7 10309 20 used use VBN cord-005453-4057qib7 10309 21 . . . cord-005453-4057qib7 10310 1 Methods method NNS cord-005453-4057qib7 10310 2 : : : cord-005453-4057qib7 10310 3 We -PRON- PRP cord-005453-4057qib7 10310 4 retrospectively retrospectively RB cord-005453-4057qib7 10310 5 analyzed analyze VBD cord-005453-4057qib7 10310 6 193 193 CD cord-005453-4057qib7 10310 7 patients patient NNS cord-005453-4057qib7 10310 8 ( ( -LRB- cord-005453-4057qib7 10310 9 225 225 CD cord-005453-4057qib7 10310 10 cases case NNS cord-005453-4057qib7 10310 11 ) ) -RRB- cord-005453-4057qib7 10310 12 who who WP cord-005453-4057qib7 10310 13 underwent undergo VBD cord-005453-4057qib7 10310 14 HD HD NNP cord-005453-4057qib7 10310 15 - - HYPH cord-005453-4057qib7 10310 16 CT CT NNP cord-005453-4057qib7 10310 17 plus plus CC cord-005453-4057qib7 10310 18 auto auto NN cord-005453-4057qib7 10310 19 PBSCT PBSCT NNP cord-005453-4057qib7 10310 20 between between IN cord-005453-4057qib7 10310 21 2011 2011 CD cord-005453-4057qib7 10310 22 and and CC cord-005453-4057qib7 10310 23 2017 2017 CD cord-005453-4057qib7 10310 24 in in IN cord-005453-4057qib7 10310 25 a a DT cord-005453-4057qib7 10310 26 single single JJ cord-005453-4057qib7 10310 27 - - HYPH cord-005453-4057qib7 10310 28 center center NN cord-005453-4057qib7 10310 29 study study NN cord-005453-4057qib7 10310 30 . . . cord-005453-4057qib7 10311 1 To to TO cord-005453-4057qib7 10311 2 anlyze anlyze VB cord-005453-4057qib7 10311 3 the the DT cord-005453-4057qib7 10311 4 incidence incidence NN cord-005453-4057qib7 10311 5 of of IN cord-005453-4057qib7 10311 6 infections infection NNS cord-005453-4057qib7 10311 7 depending depend VBG cord-005453-4057qib7 10311 8 on on IN cord-005453-4057qib7 10311 9 the the DT cord-005453-4057qib7 10311 10 conditioning conditioning NN cord-005453-4057qib7 10311 11 regimen regimen NN cord-005453-4057qib7 10311 12 , , , cord-005453-4057qib7 10311 13 we -PRON- PRP cord-005453-4057qib7 10311 14 formed form VBD cord-005453-4057qib7 10311 15 the the DT cord-005453-4057qib7 10311 16 following follow VBG cord-005453-4057qib7 10311 17 categories category NNS cord-005453-4057qib7 10311 18 based base VBN cord-005453-4057qib7 10311 19 on on IN cord-005453-4057qib7 10311 20 the the DT cord-005453-4057qib7 10311 21 AGIHO AGIHO NNP cord-005453-4057qib7 10311 22 : : : cord-005453-4057qib7 10311 23 no no DT cord-005453-4057qib7 10311 24 infections infection NNS cord-005453-4057qib7 10311 25 , , , cord-005453-4057qib7 10311 26 neutropenic neutropenic JJ cord-005453-4057qib7 10311 27 fever fever NN cord-005453-4057qib7 10311 28 , , , cord-005453-4057qib7 10311 29 sepsis sepsis NN cord-005453-4057qib7 10311 30 and and CC cord-005453-4057qib7 10311 31 severe severe JJ cord-005453-4057qib7 10311 32 sepsis sepsis NN cord-005453-4057qib7 10311 33 . . . cord-005453-4057qib7 10312 1 Results result NNS cord-005453-4057qib7 10312 2 : : : cord-005453-4057qib7 10313 1 The the DT cord-005453-4057qib7 10313 2 median median JJ cord-005453-4057qib7 10313 3 age age NN cord-005453-4057qib7 10313 4 in in IN cord-005453-4057qib7 10313 5 this this DT cord-005453-4057qib7 10313 6 analysis analysis NN cord-005453-4057qib7 10313 7 was be VBD cord-005453-4057qib7 10313 8 59 59 CD cord-005453-4057qib7 10313 9 years year NNS cord-005453-4057qib7 10313 10 ; ; : cord-005453-4057qib7 10313 11 74.2 74.2 CD cord-005453-4057qib7 10313 12 % % NN cord-005453-4057qib7 10313 13 were be VBD cord-005453-4057qib7 10313 14 male male JJ cord-005453-4057qib7 10313 15 . . . cord-005453-4057qib7 10314 1 The the DT cord-005453-4057qib7 10314 2 most most RBS cord-005453-4057qib7 10314 3 frequent frequent JJ cord-005453-4057qib7 10314 4 diagnosis diagnosis NN cord-005453-4057qib7 10314 5 was be VBD cord-005453-4057qib7 10314 6 MM MM NNP cord-005453-4057qib7 10314 7 ( ( -LRB- cord-005453-4057qib7 10314 8 62.7 62.7 CD cord-005453-4057qib7 10314 9 % % NN cord-005453-4057qib7 10314 10 ) ) -RRB- cord-005453-4057qib7 10314 11 receiving receive VBG cord-005453-4057qib7 10314 12 high high JJ cord-005453-4057qib7 10314 13 dose dose NN cord-005453-4057qib7 10314 14 melphalan melphalan NN cord-005453-4057qib7 10314 15 ( ( -LRB- cord-005453-4057qib7 10314 16 MEL MEL NNP cord-005453-4057qib7 10314 17 ) ) -RRB- cord-005453-4057qib7 10314 18 , , , cord-005453-4057qib7 10314 19 followed follow VBN cord-005453-4057qib7 10314 20 by by IN cord-005453-4057qib7 10314 21 malignant malignant JJ cord-005453-4057qib7 10314 22 lymphoma lymphoma NN cord-005453-4057qib7 10314 23 ( ( -LRB- cord-005453-4057qib7 10314 24 26.7 26.7 CD cord-005453-4057qib7 10314 25 % % NN cord-005453-4057qib7 10314 26 ) ) -RRB- cord-005453-4057qib7 10314 27 receiving receive VBG cord-005453-4057qib7 10314 28 BEAM BEAM NNP cord-005453-4057qib7 10314 29 ( ( -LRB- cord-005453-4057qib7 10314 30 BCNU BCNU NNP cord-005453-4057qib7 10314 31 , , , cord-005453-4057qib7 10314 32 etoposide etoposide JJ cord-005453-4057qib7 10314 33 cytarabine cytarabine NN cord-005453-4057qib7 10314 34 , , , cord-005453-4057qib7 10314 35 melphalan melphalan NNP cord-005453-4057qib7 10314 36 ) ) -RRB- cord-005453-4057qib7 10314 37 and and CC cord-005453-4057qib7 10314 38 relapsed relapse VBD cord-005453-4057qib7 10314 39 / / SYM cord-005453-4057qib7 10314 40 metastatic metastatic JJ cord-005453-4057qib7 10314 41 germ germ NN cord-005453-4057qib7 10314 42 cell cell NN cord-005453-4057qib7 10314 43 tumours tumour NNS cord-005453-4057qib7 10314 44 ( ( -LRB- cord-005453-4057qib7 10314 45 GCT GCT NNP cord-005453-4057qib7 10314 46 ) ) -RRB- cord-005453-4057qib7 10314 47 ( ( -LRB- cord-005453-4057qib7 10314 48 9.8 9.8 CD cord-005453-4057qib7 10314 49 % % NN cord-005453-4057qib7 10314 50 ) ) -RRB- cord-005453-4057qib7 10314 51 receiving receive VBG cord-005453-4057qib7 10314 52 high high JJ cord-005453-4057qib7 10314 53 dose dose NN cord-005453-4057qib7 10314 54 carboplatin carboplatin NNS cord-005453-4057qib7 10314 55 / / SYM cord-005453-4057qib7 10314 56 etoposide etoposide JJ cord-005453-4057qib7 10314 57 ( ( -LRB- cord-005453-4057qib7 10314 58 CE CE NNP cord-005453-4057qib7 10314 59 ) ) -RRB- cord-005453-4057qib7 10314 60 . . . cord-005453-4057qib7 10315 1 8 8 CD cord-005453-4057qib7 10315 2 % % NN cord-005453-4057qib7 10315 3 of of IN cord-005453-4057qib7 10315 4 all all DT cord-005453-4057qib7 10315 5 patients patient NNS cord-005453-4057qib7 10315 6 developed develop VBD cord-005453-4057qib7 10315 7 severe severe JJ cord-005453-4057qib7 10315 8 sepsis sepsis NN cord-005453-4057qib7 10315 9 , , , cord-005453-4057qib7 10315 10 5 5 CD cord-005453-4057qib7 10315 11 patients patient NNS cord-005453-4057qib7 10315 12 had have VBD cord-005453-4057qib7 10315 13 to to TO cord-005453-4057qib7 10315 14 be be VB cord-005453-4057qib7 10315 15 ventilated ventilate VBN cord-005453-4057qib7 10315 16 and and CC cord-005453-4057qib7 10315 17 2 2 CD cord-005453-4057qib7 10315 18 patients patient NNS cord-005453-4057qib7 10315 19 died die VBD cord-005453-4057qib7 10315 20 . . . cord-005453-4057qib7 10316 1 Sepsis sepsis NN cord-005453-4057qib7 10316 2 was be VBD cord-005453-4057qib7 10316 3 documented document VBN cord-005453-4057qib7 10316 4 in in IN cord-005453-4057qib7 10316 5 25.3 25.3 CD cord-005453-4057qib7 10316 6 % % NN cord-005453-4057qib7 10316 7 of of IN cord-005453-4057qib7 10316 8 all all DT cord-005453-4057qib7 10316 9 cases case NNS cord-005453-4057qib7 10316 10 ( ( -LRB- cord-005453-4057qib7 10316 11 57 57 CD cord-005453-4057qib7 10316 12 cases case NNS cord-005453-4057qib7 10316 13 ) ) -RRB- cord-005453-4057qib7 10316 14 . . . cord-005453-4057qib7 10317 1 The the DT cord-005453-4057qib7 10317 2 majority majority NN cord-005453-4057qib7 10317 3 of of IN cord-005453-4057qib7 10317 4 patients patient NNS cord-005453-4057qib7 10317 5 ( ( -LRB- cord-005453-4057qib7 10317 6 58.2 58.2 CD cord-005453-4057qib7 10317 7 % % NN cord-005453-4057qib7 10317 8 , , , cord-005453-4057qib7 10317 9 131 131 CD cord-005453-4057qib7 10317 10 cases case NNS cord-005453-4057qib7 10317 11 ) ) -RRB- cord-005453-4057qib7 10317 12 developed develop VBD cord-005453-4057qib7 10317 13 neutropenic neutropenic JJ cord-005453-4057qib7 10317 14 fever fever NN cord-005453-4057qib7 10317 15 and and CC cord-005453-4057qib7 10317 16 8.4 8.4 CD cord-005453-4057qib7 10317 17 % % NN cord-005453-4057qib7 10317 18 ( ( -LRB- cord-005453-4057qib7 10317 19 19 19 CD cord-005453-4057qib7 10317 20 cases case NNS cord-005453-4057qib7 10317 21 ) ) -RRB- cord-005453-4057qib7 10317 22 didn´t didn´t . cord-005453-4057qib7 10318 1 have have VBP cord-005453-4057qib7 10318 2 any any DT cord-005453-4057qib7 10318 3 infection infection NN cord-005453-4057qib7 10318 4 complications complication NNS cord-005453-4057qib7 10318 5 . . . cord-005453-4057qib7 10319 1 The the DT cord-005453-4057qib7 10319 2 BEAM BEAM NNP cord-005453-4057qib7 10319 3 conditioning conditioning NN cord-005453-4057qib7 10319 4 regimen regimen NN cord-005453-4057qib7 10319 5 showed show VBD cord-005453-4057qib7 10319 6 the the DT cord-005453-4057qib7 10319 7 highest high JJS cord-005453-4057qib7 10319 8 tendency tendency NN cord-005453-4057qib7 10319 9 to to TO cord-005453-4057qib7 10319 10 result result VB cord-005453-4057qib7 10319 11 in in IN cord-005453-4057qib7 10319 12 a a DT cord-005453-4057qib7 10319 13 septic septic JJ cord-005453-4057qib7 10319 14 course course NN cord-005453-4057qib7 10319 15 ( ( -LRB- cord-005453-4057qib7 10319 16 43.3 43.3 CD cord-005453-4057qib7 10319 17 % % NN cord-005453-4057qib7 10319 18 ) ) -RRB- cord-005453-4057qib7 10319 19 , , , cord-005453-4057qib7 10319 20 followed follow VBN cord-005453-4057qib7 10319 21 by by IN cord-005453-4057qib7 10319 22 CE CE NNP cord-005453-4057qib7 10319 23 ( ( -LRB- cord-005453-4057qib7 10319 24 27.3 27.3 CD cord-005453-4057qib7 10319 25 % % NN cord-005453-4057qib7 10319 26 ) ) -RRB- cord-005453-4057qib7 10319 27 and and CC cord-005453-4057qib7 10319 28 MEL MEL NNP cord-005453-4057qib7 10319 29 ( ( -LRB- cord-005453-4057qib7 10319 30 24.1 24.1 CD cord-005453-4057qib7 10319 31 % % NN cord-005453-4057qib7 10319 32 ) ) -RRB- cord-005453-4057qib7 10319 33 . . . cord-005453-4057qib7 10320 1 The the DT cord-005453-4057qib7 10320 2 most most RBS cord-005453-4057qib7 10320 3 commonly commonly RB cord-005453-4057qib7 10320 4 documented document VBN cord-005453-4057qib7 10320 5 pathogen pathogen NN cord-005453-4057qib7 10320 6 in in IN cord-005453-4057qib7 10320 7 153 153 CD cord-005453-4057qib7 10320 8 blood blood NN cord-005453-4057qib7 10320 9 cultures culture NNS cord-005453-4057qib7 10320 10 was be VBD cord-005453-4057qib7 10320 11 S. S. NNP cord-005453-4057qib7 10320 12 epidermidis epidermidi NNS cord-005453-4057qib7 10320 13 ( ( -LRB- cord-005453-4057qib7 10320 14 41.7 41.7 CD cord-005453-4057qib7 10320 15 % % NN cord-005453-4057qib7 10320 16 ) ) -RRB- cord-005453-4057qib7 10320 17 , , , cord-005453-4057qib7 10320 18 followed follow VBN cord-005453-4057qib7 10320 19 by by IN cord-005453-4057qib7 10320 20 E. E. NNP cord-005453-4057qib7 10320 21 coli coli NNS cord-005453-4057qib7 10320 22 ( ( -LRB- cord-005453-4057qib7 10320 23 18.5 18.5 CD cord-005453-4057qib7 10320 24 % % NN cord-005453-4057qib7 10320 25 ) ) -RRB- cord-005453-4057qib7 10320 26 and and CC cord-005453-4057qib7 10320 27 S. S. NNP cord-005453-4057qib7 10320 28 mitis mitis NNP cord-005453-4057qib7 10320 29 ( ( -LRB- cord-005453-4057qib7 10320 30 9.9 9.9 CD cord-005453-4057qib7 10320 31 % % NN cord-005453-4057qib7 10320 32 ) ) -RRB- cord-005453-4057qib7 10320 33 . . . cord-005453-4057qib7 10321 1 Only only RB cord-005453-4057qib7 10321 2 in in IN cord-005453-4057qib7 10321 3 one one CD cord-005453-4057qib7 10321 4 blood blood NN cord-005453-4057qib7 10321 5 culture culture NN cord-005453-4057qib7 10321 6 we -PRON- PRP cord-005453-4057qib7 10321 7 detected detect VBD cord-005453-4057qib7 10321 8 a a DT cord-005453-4057qib7 10321 9 multi multi JJ cord-005453-4057qib7 10321 10 - - JJ cord-005453-4057qib7 10321 11 resistant resistant JJ cord-005453-4057qib7 10321 12 pathogen pathogen NN cord-005453-4057qib7 10321 13 ( ( -LRB- cord-005453-4057qib7 10321 14 3MRGN 3mrgn CD cord-005453-4057qib7 10321 15 E. E. NNP cord-005453-4057qib7 10321 16 coli coli NNS cord-005453-4057qib7 10321 17 ) ) -RRB- cord-005453-4057qib7 10321 18 . . . cord-005453-4057qib7 10322 1 P. P. NNP cord-005453-4057qib7 10322 2 aeruginosa aeruginosa NN cord-005453-4057qib7 10322 3 was be VBD cord-005453-4057qib7 10322 4 detected detect VBN cord-005453-4057qib7 10322 5 in in IN cord-005453-4057qib7 10322 6 4 4 CD cord-005453-4057qib7 10322 7 blood blood NN cord-005453-4057qib7 10322 8 cultures culture NNS cord-005453-4057qib7 10322 9 ( ( -LRB- cord-005453-4057qib7 10322 10 2.6 2.6 CD cord-005453-4057qib7 10322 11 % % NN cord-005453-4057qib7 10322 12 ) ) -RRB- cord-005453-4057qib7 10322 13 , , , cord-005453-4057qib7 10322 14 L. L. NNP cord-005453-4057qib7 10322 15 monocytogenes monocytogenes NN cord-005453-4057qib7 10322 16 in in IN cord-005453-4057qib7 10322 17 2 2 CD cord-005453-4057qib7 10322 18 ( ( -LRB- cord-005453-4057qib7 10322 19 1.3 1.3 CD cord-005453-4057qib7 10322 20 % % NN cord-005453-4057qib7 10322 21 ) ) -RRB- cord-005453-4057qib7 10322 22 and and CC cord-005453-4057qib7 10322 23 S. S. NNP cord-005453-4057qib7 10322 24 aureus aureus NN cord-005453-4057qib7 10322 25 in in IN cord-005453-4057qib7 10322 26 6 6 CD cord-005453-4057qib7 10322 27 ( ( -LRB- cord-005453-4057qib7 10322 28 4 4 CD cord-005453-4057qib7 10322 29 % % NN cord-005453-4057qib7 10322 30 ) ) -RRB- cord-005453-4057qib7 10322 31 . . . cord-005453-4057qib7 10323 1 77.8 77.8 CD cord-005453-4057qib7 10323 2 % % NN cord-005453-4057qib7 10323 3 of of IN cord-005453-4057qib7 10323 4 all all DT cord-005453-4057qib7 10323 5 patients patient NNS cord-005453-4057qib7 10323 6 developed develop VBD cord-005453-4057qib7 10323 7 diarrhea diarrhea NN cord-005453-4057qib7 10323 8 , , , cord-005453-4057qib7 10323 9 only only RB cord-005453-4057qib7 10323 10 in in IN cord-005453-4057qib7 10323 11 10.9 10.9 CD cord-005453-4057qib7 10323 12 % % NN cord-005453-4057qib7 10323 13 of of IN cord-005453-4057qib7 10323 14 these these DT cord-005453-4057qib7 10323 15 cases case NNS cord-005453-4057qib7 10323 16 we -PRON- PRP cord-005453-4057qib7 10323 17 could could MD cord-005453-4057qib7 10323 18 detect detect VB cord-005453-4057qib7 10323 19 C. C. NNP cord-005453-4057qib7 10323 20 difficile difficile NN cord-005453-4057qib7 10323 21 . . . cord-005453-4057qib7 10324 1 The the DT cord-005453-4057qib7 10324 2 conditioning conditioning NN cord-005453-4057qib7 10324 3 regimen regimen NN cord-005453-4057qib7 10324 4 shows show VBZ cord-005453-4057qib7 10324 5 no no DT cord-005453-4057qib7 10324 6 significant significant JJ cord-005453-4057qib7 10324 7 effect effect NN cord-005453-4057qib7 10324 8 on on IN cord-005453-4057qib7 10324 9 the the DT cord-005453-4057qib7 10324 10 incidence incidence NN cord-005453-4057qib7 10324 11 of of IN cord-005453-4057qib7 10324 12 C. C. NNP cord-005453-4057qib7 10324 13 difficile difficile NN cord-005453-4057qib7 10324 14 . . . cord-005453-4057qib7 10325 1 The the DT cord-005453-4057qib7 10325 2 mean mean NN cord-005453-4057qib7 10325 3 neutropenic neutropenic JJ cord-005453-4057qib7 10325 4 period period NN cord-005453-4057qib7 10325 5 was be VBD cord-005453-4057qib7 10325 6 13.5 13.5 CD cord-005453-4057qib7 10325 7 days day NNS cord-005453-4057qib7 10325 8 in in IN cord-005453-4057qib7 10325 9 malignant malignant JJ cord-005453-4057qib7 10325 10 lymphoma lymphoma NN cord-005453-4057qib7 10325 11 patients patient NNS cord-005453-4057qib7 10325 12 , , , cord-005453-4057qib7 10325 13 followed follow VBN cord-005453-4057qib7 10325 14 by by IN cord-005453-4057qib7 10325 15 10.8 10.8 CD cord-005453-4057qib7 10325 16 in in IN cord-005453-4057qib7 10325 17 MM MM NNP cord-005453-4057qib7 10325 18 patients patient NNS cord-005453-4057qib7 10325 19 and and CC cord-005453-4057qib7 10325 20 8.7 8.7 CD cord-005453-4057qib7 10325 21 days day NNS cord-005453-4057qib7 10325 22 in in IN cord-005453-4057qib7 10325 23 GCT GCT NNP cord-005453-4057qib7 10325 24 patients patient NNS cord-005453-4057qib7 10325 25 . . . cord-005453-4057qib7 10326 1 The the DT cord-005453-4057qib7 10326 2 hospital hospital NN cord-005453-4057qib7 10326 3 discharge discharge NN cord-005453-4057qib7 10326 4 , , , cord-005453-4057qib7 10326 5 calculated calculate VBN cord-005453-4057qib7 10326 6 from from IN cord-005453-4057qib7 10326 7 the the DT cord-005453-4057qib7 10326 8 day day NN cord-005453-4057qib7 10326 9 of of IN cord-005453-4057qib7 10326 10 transplantation transplantation NN cord-005453-4057qib7 10326 11 , , , cord-005453-4057qib7 10326 12 was be VBD cord-005453-4057qib7 10326 13 significantly significantly RB cord-005453-4057qib7 10326 14 different different JJ cord-005453-4057qib7 10326 15 : : : cord-005453-4057qib7 10326 16 for for IN cord-005453-4057qib7 10326 17 malignant malignant JJ cord-005453-4057qib7 10326 18 lymphoma lymphoma NN cord-005453-4057qib7 10327 1 the the DT cord-005453-4057qib7 10327 2 mean mean NN cord-005453-4057qib7 10327 3 was be VBD cord-005453-4057qib7 10327 4 20.8 20.8 CD cord-005453-4057qib7 10327 5 days day NNS cord-005453-4057qib7 10327 6 , , , cord-005453-4057qib7 10327 7 for for IN cord-005453-4057qib7 10327 8 MM MM NNP cord-005453-4057qib7 10327 9 19.6 19.6 CD cord-005453-4057qib7 10327 10 days day NNS cord-005453-4057qib7 10327 11 and and CC cord-005453-4057qib7 10327 12 for for IN cord-005453-4057qib7 10327 13 GCT GCT NNP cord-005453-4057qib7 10327 14 14.5 14.5 CD cord-005453-4057qib7 10327 15 days day NNS cord-005453-4057qib7 10327 16 . . . cord-005453-4057qib7 10328 1 Conclusions conclusion NNS cord-005453-4057qib7 10328 2 : : : cord-005453-4057qib7 10329 1 Our -PRON- PRP$ cord-005453-4057qib7 10329 2 data datum NNS cord-005453-4057qib7 10329 3 correspond correspond VBP cord-005453-4057qib7 10329 4 to to IN cord-005453-4057qib7 10329 5 former former JJ cord-005453-4057qib7 10329 6 published publish VBN cord-005453-4057qib7 10329 7 results result NNS cord-005453-4057qib7 10329 8 by by IN cord-005453-4057qib7 10329 9 many many JJ cord-005453-4057qib7 10329 10 groups group NNS cord-005453-4057qib7 10329 11 . . . cord-005453-4057qib7 10330 1 The the DT cord-005453-4057qib7 10330 2 BEAM BEAM NNP cord-005453-4057qib7 10330 3 regimen regimen NN cord-005453-4057qib7 10330 4 shows show VBZ cord-005453-4057qib7 10330 5 the the DT cord-005453-4057qib7 10330 6 highest high JJS cord-005453-4057qib7 10330 7 infectious infectious JJ cord-005453-4057qib7 10330 8 complication complication NN cord-005453-4057qib7 10330 9 rate rate NN cord-005453-4057qib7 10330 10 followed follow VBN cord-005453-4057qib7 10330 11 by by IN cord-005453-4057qib7 10330 12 CE CE NNP cord-005453-4057qib7 10330 13 and and CC cord-005453-4057qib7 10330 14 MEL MEL NNP cord-005453-4057qib7 10330 15 . . . cord-005453-4057qib7 10331 1 The the DT cord-005453-4057qib7 10331 2 duration duration NN cord-005453-4057qib7 10331 3 of of IN cord-005453-4057qib7 10331 4 neutropenia neutropenia NN cord-005453-4057qib7 10331 5 and and CC cord-005453-4057qib7 10331 6 hospital hospital NN cord-005453-4057qib7 10331 7 stay stay NN cord-005453-4057qib7 10331 8 depends depend VBZ cord-005453-4057qib7 10331 9 on on IN cord-005453-4057qib7 10331 10 the the DT cord-005453-4057qib7 10331 11 conditioning conditioning NN cord-005453-4057qib7 10331 12 regimen regimen NN cord-005453-4057qib7 10331 13 . . . cord-005453-4057qib7 10332 1 The the DT cord-005453-4057qib7 10332 2 type type NN cord-005453-4057qib7 10332 3 of of IN cord-005453-4057qib7 10332 4 infectious infectious JJ cord-005453-4057qib7 10332 5 complication complication NN cord-005453-4057qib7 10332 6 does do VBZ cord-005453-4057qib7 10332 7 n't not RB cord-005453-4057qib7 10332 8 effect effect VB cord-005453-4057qib7 10332 9 the the DT cord-005453-4057qib7 10332 10 progression progression NN cord-005453-4057qib7 10332 11 free free JJ cord-005453-4057qib7 10332 12 - - HYPH cord-005453-4057qib7 10332 13 and and CC cord-005453-4057qib7 10332 14 overall overall JJ cord-005453-4057qib7 10332 15 survival survival NN cord-005453-4057qib7 10332 16 in in IN cord-005453-4057qib7 10332 17 our -PRON- PRP$ cord-005453-4057qib7 10332 18 analysis analysis NN cord-005453-4057qib7 10332 19 . . . cord-005453-4057qib7 10333 1 Disclosure disclosure NN cord-005453-4057qib7 10333 2 : : : cord-005453-4057qib7 10333 3 Nothing nothing NN cord-005453-4057qib7 10333 4 to to TO cord-005453-4057qib7 10333 5 declare declare VB cord-005453-4057qib7 10333 6 . . . cord-005453-4057qib7 10334 1 Impact impact NN cord-005453-4057qib7 10334 2 of of IN cord-005453-4057qib7 10334 3 donor donor NN cord-005453-4057qib7 10334 4 and and CC cord-005453-4057qib7 10334 5 recipient recipient NN cord-005453-4057qib7 10334 6 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 10334 7 serostatus serostatus NN cord-005453-4057qib7 10334 8 on on IN cord-005453-4057qib7 10334 9 outcomes outcome NNS cord-005453-4057qib7 10334 10 of of IN cord-005453-4057qib7 10334 11 unrelated unrelated JJ cord-005453-4057qib7 10334 12 allogeneic allogeneic IN cord-005453-4057qib7 10334 13 haematopoietic haematopoietic JJ cord-005453-4057qib7 10334 14 stem stem NN cord-005453-4057qib7 10334 15 cell cell NN cord-005453-4057qib7 10334 16 transplantation transplantation NN cord-005453-4057qib7 10334 17 Background background NN cord-005453-4057qib7 10334 18 : : : cord-005453-4057qib7 10334 19 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 10334 20 ( ( -LRB- cord-005453-4057qib7 10334 21 CMV CMV NNP cord-005453-4057qib7 10334 22 ) ) -RRB- cord-005453-4057qib7 10334 23 is be VBZ cord-005453-4057qib7 10334 24 an an DT cord-005453-4057qib7 10334 25 important important JJ cord-005453-4057qib7 10334 26 cause cause NN cord-005453-4057qib7 10334 27 of of IN cord-005453-4057qib7 10334 28 morbidity morbidity NN cord-005453-4057qib7 10334 29 and and CC cord-005453-4057qib7 10334 30 mortality mortality NN cord-005453-4057qib7 10334 31 in in IN cord-005453-4057qib7 10334 32 allogeneic allogeneic JJ cord-005453-4057qib7 10334 33 haematopoietic haematopoietic JJ cord-005453-4057qib7 10334 34 stem stem NN cord-005453-4057qib7 10334 35 cell cell NN cord-005453-4057qib7 10334 36 transplant transplant NN cord-005453-4057qib7 10334 37 ( ( -LRB- cord-005453-4057qib7 10334 38 HSCT HSCT NNP cord-005453-4057qib7 10334 39 ) ) -RRB- cord-005453-4057qib7 10334 40 patients patient NNS cord-005453-4057qib7 10334 41 . . . cord-005453-4057qib7 10335 1 The the DT cord-005453-4057qib7 10335 2 aim aim NN cord-005453-4057qib7 10335 3 of of IN cord-005453-4057qib7 10335 4 our -PRON- PRP$ cord-005453-4057qib7 10335 5 study study NN cord-005453-4057qib7 10335 6 is be VBZ cord-005453-4057qib7 10335 7 to to TO cord-005453-4057qib7 10335 8 evaluate evaluate VB cord-005453-4057qib7 10335 9 the the DT cord-005453-4057qib7 10335 10 outcomes outcome NNS cord-005453-4057qib7 10335 11 of of IN cord-005453-4057qib7 10335 12 our -PRON- PRP$ cord-005453-4057qib7 10335 13 CMV CMV NNP cord-005453-4057qib7 10335 14 seropositive seropositive JJ cord-005453-4057qib7 10335 15 recipients recipient NNS cord-005453-4057qib7 10335 16 who who WP cord-005453-4057qib7 10335 17 received receive VBD cord-005453-4057qib7 10335 18 grafts graft NNS cord-005453-4057qib7 10335 19 from from IN cord-005453-4057qib7 10335 20 seropositive seropositive JJ cord-005453-4057qib7 10335 21 unrelated unrelated JJ cord-005453-4057qib7 10335 22 donors donor NNS cord-005453-4057qib7 10335 23 ( ( -LRB- cord-005453-4057qib7 10335 24 D+R+ D+R+ NNP cord-005453-4057qib7 10335 25 ) ) -RRB- cord-005453-4057qib7 10335 26 compared compare VBN cord-005453-4057qib7 10335 27 with with IN cord-005453-4057qib7 10335 28 grafts graft NNS cord-005453-4057qib7 10335 29 from from IN cord-005453-4057qib7 10335 30 seronegative seronegative JJ cord-005453-4057qib7 10335 31 unrelated unrelated JJ cord-005453-4057qib7 10335 32 donors donor NNS cord-005453-4057qib7 10335 33 ( ( -LRB- cord-005453-4057qib7 10335 34 D d NN cord-005453-4057qib7 10335 35 - - HYPH cord-005453-4057qib7 10335 36 R+ r+ NN cord-005453-4057qib7 10335 37 ) ) -RRB- cord-005453-4057qib7 10335 38 . . . cord-005453-4057qib7 10336 1 Methods method NNS cord-005453-4057qib7 10336 2 : : : cord-005453-4057qib7 10336 3 This this DT cord-005453-4057qib7 10336 4 is be VBZ cord-005453-4057qib7 10336 5 a a DT cord-005453-4057qib7 10336 6 retrospective retrospective JJ cord-005453-4057qib7 10336 7 single single JJ cord-005453-4057qib7 10336 8 center center NN cord-005453-4057qib7 10336 9 study study NN cord-005453-4057qib7 10336 10 on on IN cord-005453-4057qib7 10336 11 a a DT cord-005453-4057qib7 10336 12 series series NN cord-005453-4057qib7 10336 13 of of IN cord-005453-4057qib7 10336 14 CMV CMV NNP cord-005453-4057qib7 10336 15 seropositive seropositive JJ cord-005453-4057qib7 10336 16 recipients recipient NNS cord-005453-4057qib7 10336 17 who who WP cord-005453-4057qib7 10336 18 underwent undergo VBD cord-005453-4057qib7 10336 19 HSCT HSCT NNP cord-005453-4057qib7 10336 20 from from IN cord-005453-4057qib7 10336 21 unrelated unrelated JJ cord-005453-4057qib7 10336 22 donors donor NNS cord-005453-4057qib7 10336 23 between between IN cord-005453-4057qib7 10336 24 Febuary Febuary NNP cord-005453-4057qib7 10336 25 2012 2012 CD cord-005453-4057qib7 10336 26 to to IN cord-005453-4057qib7 10336 27 July July NNP cord-005453-4057qib7 10336 28 2018 2018 CD cord-005453-4057qib7 10336 29 . . . cord-005453-4057qib7 10337 1 A a DT cord-005453-4057qib7 10337 2 total total NN cord-005453-4057qib7 10337 3 of of IN cord-005453-4057qib7 10337 4 96 96 CD cord-005453-4057qib7 10337 5 patients patient NNS cord-005453-4057qib7 10337 6 were be VBD cord-005453-4057qib7 10337 7 analyzed analyze VBN cord-005453-4057qib7 10337 8 . . . cord-005453-4057qib7 10338 1 Their -PRON- PRP$ cord-005453-4057qib7 10338 2 clinical clinical JJ cord-005453-4057qib7 10338 3 course course NN cord-005453-4057qib7 10338 4 and and CC cord-005453-4057qib7 10338 5 laboratory laboratory NN cord-005453-4057qib7 10338 6 results result NNS cord-005453-4057qib7 10338 7 were be VBD cord-005453-4057qib7 10338 8 reviewed review VBN cord-005453-4057qib7 10338 9 for for IN cord-005453-4057qib7 10338 10 evidence evidence NN cord-005453-4057qib7 10338 11 of of IN cord-005453-4057qib7 10338 12 CMV CMV NNP cord-005453-4057qib7 10338 13 reactivation reactivation NN cord-005453-4057qib7 10338 14 and/or and/or CC cord-005453-4057qib7 10338 15 CMV CMV NNP cord-005453-4057qib7 10338 16 disease disease NN cord-005453-4057qib7 10338 17 . . . cord-005453-4057qib7 10339 1 We -PRON- PRP cord-005453-4057qib7 10339 2 defined define VBD cord-005453-4057qib7 10339 3 CMV CMV NNP cord-005453-4057qib7 10339 4 infection infection NN cord-005453-4057qib7 10339 5 as as IN cord-005453-4057qib7 10339 6 detection detection NN cord-005453-4057qib7 10339 7 of of IN cord-005453-4057qib7 10339 8 CMV CMV NNP cord-005453-4057qib7 10339 9 reactivation reactivation NN cord-005453-4057qib7 10339 10 or or CC cord-005453-4057qib7 10339 11 primary primary JJ cord-005453-4057qib7 10339 12 infection infection NN cord-005453-4057qib7 10339 13 by by IN cord-005453-4057qib7 10339 14 antigenaemia antigenaemia NN cord-005453-4057qib7 10339 15 or or CC cord-005453-4057qib7 10339 16 polymerase polymerase NN cord-005453-4057qib7 10339 17 chain chain NN cord-005453-4057qib7 10339 18 reaction reaction NN cord-005453-4057qib7 10339 19 ( ( -LRB- cord-005453-4057qib7 10339 20 PCR PCR NNP cord-005453-4057qib7 10339 21 ) ) -RRB- cord-005453-4057qib7 10339 22 assays assay NNS cord-005453-4057qib7 10339 23 , , , cord-005453-4057qib7 10339 24 but but CC cord-005453-4057qib7 10339 25 was be VBD cord-005453-4057qib7 10339 26 not not RB cord-005453-4057qib7 10339 27 accompanied accompany VBN cord-005453-4057qib7 10339 28 by by IN cord-005453-4057qib7 10339 29 signs sign NNS cord-005453-4057qib7 10339 30 and/or and/or CC cord-005453-4057qib7 10339 31 symptoms symptom NNS cord-005453-4057qib7 10339 32 suggestive suggestive JJ cord-005453-4057qib7 10339 33 of of IN cord-005453-4057qib7 10339 34 a a DT cord-005453-4057qib7 10339 35 systemic systemic JJ cord-005453-4057qib7 10339 36 disease disease NN cord-005453-4057qib7 10339 37 . . . cord-005453-4057qib7 10340 1 CMV CMV NNP cord-005453-4057qib7 10340 2 disease disease NN cord-005453-4057qib7 10340 3 occurred occur VBD cord-005453-4057qib7 10340 4 when when WRB cord-005453-4057qib7 10340 5 CMV CMV NNP cord-005453-4057qib7 10340 6 was be VBD cord-005453-4057qib7 10340 7 isolated isolate VBN cord-005453-4057qib7 10340 8 from from IN cord-005453-4057qib7 10340 9 any any DT cord-005453-4057qib7 10340 10 site site NN cord-005453-4057qib7 10340 11 in in IN cord-005453-4057qib7 10340 12 association association NN cord-005453-4057qib7 10340 13 with with IN cord-005453-4057qib7 10340 14 organspecific organspecific JJ cord-005453-4057qib7 10340 15 signs sign NNS cord-005453-4057qib7 10340 16 and/or and/or CC cord-005453-4057qib7 10340 17 symptoms symptom NNS cord-005453-4057qib7 10340 18 . . . cord-005453-4057qib7 10341 1 Monitoring monitor VBG cord-005453-4057qib7 10341 2 for for IN cord-005453-4057qib7 10341 3 CMV CMV NNP cord-005453-4057qib7 10341 4 infection infection NN cord-005453-4057qib7 10341 5 commenced commence VBD cord-005453-4057qib7 10341 6 upon upon IN cord-005453-4057qib7 10341 7 engraftment engraftment NNP cord-005453-4057qib7 10341 8 ( ( -LRB- cord-005453-4057qib7 10341 9 approximately approximately RB cord-005453-4057qib7 10341 10 Day day NN cord-005453-4057qib7 10341 11 +14 +14 CD cord-005453-4057qib7 10341 12 ) ) -RRB- cord-005453-4057qib7 10341 13 . . . cord-005453-4057qib7 10342 1 Peripheral peripheral JJ cord-005453-4057qib7 10342 2 blood blood NN cord-005453-4057qib7 10342 3 samples sample NNS cord-005453-4057qib7 10342 4 were be VBD cord-005453-4057qib7 10342 5 sent send VBN cord-005453-4057qib7 10342 6 twice twice RB cord-005453-4057qib7 10342 7 a a DT cord-005453-4057qib7 10342 8 week week NN cord-005453-4057qib7 10342 9 for for IN cord-005453-4057qib7 10342 10 CMV CMV NNP cord-005453-4057qib7 10342 11 antigenaemia antigenaemia NN cord-005453-4057qib7 10342 12 or or CC cord-005453-4057qib7 10342 13 CMV CMV NNP cord-005453-4057qib7 10342 14 quantitative quantitative JJ cord-005453-4057qib7 10342 15 PCR PCR NNP cord-005453-4057qib7 10342 16 . . . cord-005453-4057qib7 10343 1 The the DT cord-005453-4057qib7 10343 2 duration duration NN cord-005453-4057qib7 10343 3 of of IN cord-005453-4057qib7 10343 4 twice twice JJ cord-005453-4057qib7 10343 5 weekly weekly JJ cord-005453-4057qib7 10343 6 monitoring monitoring NN cord-005453-4057qib7 10343 7 was be VBD cord-005453-4057qib7 10343 8 at at IN cord-005453-4057qib7 10343 9 least least JJS cord-005453-4057qib7 10343 10 about about RB cord-005453-4057qib7 10343 11 100 100 CD cord-005453-4057qib7 10343 12 days day NNS cord-005453-4057qib7 10343 13 . . . cord-005453-4057qib7 10344 1 Longer long RBR cord-005453-4057qib7 10344 2 monitoring monitoring NN cord-005453-4057qib7 10344 3 was be VBD cord-005453-4057qib7 10344 4 performed perform VBN cord-005453-4057qib7 10344 5 in in IN cord-005453-4057qib7 10344 6 patients patient NNS cord-005453-4057qib7 10344 7 who who WP cord-005453-4057qib7 10344 8 experienced experience VBD cord-005453-4057qib7 10344 9 CMV CMV NNP cord-005453-4057qib7 10344 10 infection infection NN cord-005453-4057qib7 10344 11 after after IN cord-005453-4057qib7 10344 12 HSCT HSCT NNP cord-005453-4057qib7 10344 13 . . . cord-005453-4057qib7 10345 1 Results result NNS cord-005453-4057qib7 10345 2 : : : cord-005453-4057qib7 10346 1 All all DT cord-005453-4057qib7 10346 2 patients patient NNS cord-005453-4057qib7 10346 3 received receive VBD cord-005453-4057qib7 10346 4 graft graft NN cord-005453-4057qib7 10346 5 - - HYPH cord-005453-4057qib7 10346 6 versus versus IN cord-005453-4057qib7 10346 7 - - HYPH cord-005453-4057qib7 10346 8 host host NN cord-005453-4057qib7 10346 9 - - HYPH cord-005453-4057qib7 10346 10 disease disease NN cord-005453-4057qib7 10346 11 ( ( -LRB- cord-005453-4057qib7 10346 12 GVHD GVHD NNP cord-005453-4057qib7 10346 13 ) ) -RRB- cord-005453-4057qib7 10346 14 prophylaxis prophylaxis NN cord-005453-4057qib7 10346 15 using use VBG cord-005453-4057qib7 10346 16 Anti Anti NNP cord-005453-4057qib7 10346 17 - - NNP cord-005453-4057qib7 10346 18 Thymocyte Thymocyte NNP cord-005453-4057qib7 10346 19 globulin globulin NN cord-005453-4057qib7 10346 20 ( ( -LRB- cord-005453-4057qib7 10346 21 ATG ATG NNP cord-005453-4057qib7 10346 22 ) ) -RRB- cord-005453-4057qib7 10346 23 at at IN cord-005453-4057qib7 10346 24 4.5mg 4.5mg CD cord-005453-4057qib7 10346 25 / / SYM cord-005453-4057qib7 10346 26 kg kg NNS cord-005453-4057qib7 10346 27 in in IN cord-005453-4057qib7 10346 28 addition addition NN cord-005453-4057qib7 10346 29 to to IN cord-005453-4057qib7 10346 30 cyclosporin cyclosporin NN cord-005453-4057qib7 10346 31 or or CC cord-005453-4057qib7 10346 32 tacrolimus tacrolimus NN cord-005453-4057qib7 10346 33 . . . cord-005453-4057qib7 10347 1 Among among IN cord-005453-4057qib7 10347 2 the the DT cord-005453-4057qib7 10347 3 entire entire JJ cord-005453-4057qib7 10347 4 cohort cohort NN cord-005453-4057qib7 10347 5 of of IN cord-005453-4057qib7 10347 6 96 96 CD cord-005453-4057qib7 10347 7 patients patient NNS cord-005453-4057qib7 10347 8 , , , cord-005453-4057qib7 10347 9 72 72 CD cord-005453-4057qib7 10347 10 ( ( -LRB- cord-005453-4057qib7 10347 11 75 75 CD cord-005453-4057qib7 10347 12 % % NN cord-005453-4057qib7 10347 13 ) ) -RRB- cord-005453-4057qib7 10347 14 had have VBD cord-005453-4057qib7 10347 15 CMV CMV NNP cord-005453-4057qib7 10347 16 infection infection NN cord-005453-4057qib7 10347 17 , , , cord-005453-4057qib7 10347 18 including include VBG cord-005453-4057qib7 10347 19 23 23 CD cord-005453-4057qib7 10347 20 ( ( -LRB- cord-005453-4057qib7 10347 21 82.1 82.1 CD cord-005453-4057qib7 10347 22 % % NN cord-005453-4057qib7 10347 23 ) ) -RRB- cord-005453-4057qib7 10347 24 out out IN cord-005453-4057qib7 10347 25 of of IN cord-005453-4057qib7 10347 26 28 28 CD cord-005453-4057qib7 10347 27 patients patient NNS cord-005453-4057qib7 10347 28 from from IN cord-005453-4057qib7 10347 29 the the DT cord-005453-4057qib7 10347 30 D d NN cord-005453-4057qib7 10347 31 - - HYPH cord-005453-4057qib7 10347 32 R+ r+ NN cord-005453-4057qib7 10347 33 group group NN cord-005453-4057qib7 10347 34 and and CC cord-005453-4057qib7 10347 35 49 49 CD cord-005453-4057qib7 10347 36 ( ( -LRB- cord-005453-4057qib7 10347 37 72 72 CD cord-005453-4057qib7 10347 38 % % NN cord-005453-4057qib7 10347 39 ) ) -RRB- cord-005453-4057qib7 10347 40 out out IN cord-005453-4057qib7 10347 41 of of IN cord-005453-4057qib7 10347 42 68 68 CD cord-005453-4057qib7 10347 43 patients patient NNS cord-005453-4057qib7 10347 44 from from IN cord-005453-4057qib7 10347 45 the the DT cord-005453-4057qib7 10347 46 D+R D+R NNP cord-005453-4057qib7 10347 47 + + CC cord-005453-4057qib7 10347 48 group group NN cord-005453-4057qib7 10347 49 . . . cord-005453-4057qib7 10348 1 16 16 CD cord-005453-4057qib7 10348 2 patients patient NNS cord-005453-4057qib7 10348 3 ( ( -LRB- cord-005453-4057qib7 10348 4 57.1 57.1 CD cord-005453-4057qib7 10348 5 % % NN cord-005453-4057qib7 10348 6 ) ) -RRB- cord-005453-4057qib7 10348 7 from from IN cord-005453-4057qib7 10348 8 the the DT cord-005453-4057qib7 10348 9 D d NN cord-005453-4057qib7 10348 10 - - HYPH cord-005453-4057qib7 10348 11 R+ r+ NN cord-005453-4057qib7 10348 12 group group NN cord-005453-4057qib7 10348 13 and and CC cord-005453-4057qib7 10348 14 19 19 CD cord-005453-4057qib7 10348 15 patients patient NNS cord-005453-4057qib7 10348 16 ( ( -LRB- cord-005453-4057qib7 10348 17 27.5 27.5 CD cord-005453-4057qib7 10348 18 % % NN cord-005453-4057qib7 10348 19 ) ) -RRB- cord-005453-4057qib7 10348 20 from from IN cord-005453-4057qib7 10348 21 the the DT cord-005453-4057qib7 10348 22 D+R+ D+R+ NNP cord-005453-4057qib7 10348 23 group group NN cord-005453-4057qib7 10348 24 had have VBD cord-005453-4057qib7 10348 25 ≧2 ≧2 NNS cord-005453-4057qib7 10349 1 CMV CMV NNP cord-005453-4057qib7 10349 2 reactivation reactivation NN cord-005453-4057qib7 10349 3 above above IN cord-005453-4057qib7 10349 4 the the DT cord-005453-4057qib7 10349 5 threshold threshold NN cord-005453-4057qib7 10349 6 for for IN cord-005453-4057qib7 10349 7 preemptive preemptive JJ cord-005453-4057qib7 10349 8 therapy therapy NN cord-005453-4057qib7 10349 9 respectively respectively RB cord-005453-4057qib7 10349 10 ; ; : cord-005453-4057qib7 10349 11 p=0.007 p=0.007 VB cord-005453-4057qib7 10349 12 . . . cord-005453-4057qib7 10350 1 11 11 CD cord-005453-4057qib7 10350 2 patients patient NNS cord-005453-4057qib7 10350 3 developed develop VBD cord-005453-4057qib7 10350 4 CMV CMV NNP cord-005453-4057qib7 10350 5 disease disease NN cord-005453-4057qib7 10350 6 , , , cord-005453-4057qib7 10350 7 6 6 CD cord-005453-4057qib7 10350 8 ( ( -LRB- cord-005453-4057qib7 10350 9 21.4 21.4 CD cord-005453-4057qib7 10350 10 % % NN cord-005453-4057qib7 10350 11 ) ) -RRB- cord-005453-4057qib7 10350 12 from from IN cord-005453-4057qib7 10350 13 the the DT cord-005453-4057qib7 10350 14 D d NN cord-005453-4057qib7 10350 15 - - HYPH cord-005453-4057qib7 10350 16 R+ r+ NN cord-005453-4057qib7 10350 17 group group NN cord-005453-4057qib7 10350 18 and and CC cord-005453-4057qib7 10350 19 5 5 CD cord-005453-4057qib7 10350 20 ( ( -LRB- cord-005453-4057qib7 10350 21 7.4 7.4 CD cord-005453-4057qib7 10350 22 % % NN cord-005453-4057qib7 10350 23 ) ) -RRB- cord-005453-4057qib7 10350 24 from from IN cord-005453-4057qib7 10350 25 the the DT cord-005453-4057qib7 10350 26 D d NN cord-005453-4057qib7 10350 27 + + CC cord-005453-4057qib7 10350 28 R+ r+ NN cord-005453-4057qib7 10350 29 group group NN cord-005453-4057qib7 10350 30 . . . cord-005453-4057qib7 10351 1 CMV CMV NNP cord-005453-4057qib7 10351 2 resistance resistance NN cord-005453-4057qib7 10351 3 to to IN cord-005453-4057qib7 10351 4 both both DT cord-005453-4057qib7 10351 5 foscarnet foscarnet VB cord-005453-4057qib7 10351 6 and and CC cord-005453-4057qib7 10351 7 ganciclovir ganciclovir NNP cord-005453-4057qib7 10351 8 was be VBD cord-005453-4057qib7 10351 9 detected detect VBN cord-005453-4057qib7 10351 10 in in IN cord-005453-4057qib7 10351 11 3 3 CD cord-005453-4057qib7 10351 12 patients patient NNS cord-005453-4057qib7 10351 13 ( ( -LRB- cord-005453-4057qib7 10351 14 10.7 10.7 CD cord-005453-4057qib7 10351 15 % % NN cord-005453-4057qib7 10351 16 ) ) -RRB- cord-005453-4057qib7 10351 17 from from IN cord-005453-4057qib7 10351 18 the the DT cord-005453-4057qib7 10351 19 D d NN cord-005453-4057qib7 10351 20 - - HYPH cord-005453-4057qib7 10351 21 R+ r+ NN cord-005453-4057qib7 10351 22 group group NN cord-005453-4057qib7 10351 23 but but CC cord-005453-4057qib7 10351 24 none none NN cord-005453-4057qib7 10351 25 from from IN cord-005453-4057qib7 10351 26 the the DT cord-005453-4057qib7 10351 27 D+R+ D+R+ NNP cord-005453-4057qib7 10351 28 group group NN cord-005453-4057qib7 10351 29 . . . cord-005453-4057qib7 10352 1 2 2 CD cord-005453-4057qib7 10352 2 patients patient NNS cord-005453-4057qib7 10352 3 died die VBD cord-005453-4057qib7 10352 4 due due IN cord-005453-4057qib7 10352 5 to to IN cord-005453-4057qib7 10352 6 CMV CMV NNP cord-005453-4057qib7 10352 7 disease disease NN cord-005453-4057qib7 10352 8 , , , cord-005453-4057qib7 10352 9 both both DT cord-005453-4057qib7 10352 10 were be VBD cord-005453-4057qib7 10352 11 from from IN cord-005453-4057qib7 10352 12 D d NN cord-005453-4057qib7 10352 13 - - HYPH cord-005453-4057qib7 10352 14 R+ r+ NN cord-005453-4057qib7 10352 15 group group NN cord-005453-4057qib7 10352 16 . . . cord-005453-4057qib7 10353 1 2 2 CD cord-005453-4057qib7 10353 2 year year NN cord-005453-4057qib7 10353 3 overall overall JJ cord-005453-4057qib7 10353 4 survival survival NN cord-005453-4057qib7 10353 5 ( ( -LRB- cord-005453-4057qib7 10353 6 OS OS NNP cord-005453-4057qib7 10353 7 ) ) -RRB- cord-005453-4057qib7 10353 8 were be VBD cord-005453-4057qib7 10353 9 60 60 CD cord-005453-4057qib7 10353 10 % % NN cord-005453-4057qib7 10353 11 versus versus IN cord-005453-4057qib7 10353 12 55 55 CD cord-005453-4057qib7 10353 13 % % NN cord-005453-4057qib7 10353 14 for for IN cord-005453-4057qib7 10353 15 D d NN cord-005453-4057qib7 10353 16 - - HYPH cord-005453-4057qib7 10353 17 R+ r+ NN cord-005453-4057qib7 10353 18 group group NN cord-005453-4057qib7 10353 19 and and CC cord-005453-4057qib7 10353 20 D+R+ D+R+ NNP cord-005453-4057qib7 10353 21 group group NN cord-005453-4057qib7 10353 22 respectively respectively RB cord-005453-4057qib7 10353 23 ; ; . cord-005453-4057qib7 10354 1 p=0.706 p=0.706 NNP cord-005453-4057qib7 10354 2 . . . cord-005453-4057qib7 10355 1 Median median JJ cord-005453-4057qib7 10355 2 survival survival NN cord-005453-4057qib7 10355 3 was be VBD cord-005453-4057qib7 10355 4 not not RB cord-005453-4057qib7 10355 5 reached reach VBN cord-005453-4057qib7 10355 6 at at IN cord-005453-4057qib7 10355 7 2 2 CD cord-005453-4057qib7 10355 8 years year NNS cord-005453-4057qib7 10355 9 . . . cord-005453-4057qib7 10356 1 2 2 CD cord-005453-4057qib7 10356 2 year year NN cord-005453-4057qib7 10356 3 non non JJ cord-005453-4057qib7 10356 4 - - JJ cord-005453-4057qib7 10356 5 relapse relapse JJ cord-005453-4057qib7 10356 6 mortality mortality NN cord-005453-4057qib7 10356 7 ( ( -LRB- cord-005453-4057qib7 10356 8 NRM NRM NNP cord-005453-4057qib7 10356 9 ) ) -RRB- cord-005453-4057qib7 10356 10 were be VBD cord-005453-4057qib7 10356 11 35 35 CD cord-005453-4057qib7 10356 12 % % NN cord-005453-4057qib7 10356 13 for for IN cord-005453-4057qib7 10356 14 D d NN cord-005453-4057qib7 10356 15 - - HYPH cord-005453-4057qib7 10356 16 R+ r+ NN cord-005453-4057qib7 10356 17 group group NN cord-005453-4057qib7 10356 18 and and CC cord-005453-4057qib7 10356 19 24 24 CD cord-005453-4057qib7 10356 20 % % NN cord-005453-4057qib7 10356 21 for for IN cord-005453-4057qib7 10356 22 D d NN cord-005453-4057qib7 10356 23 + + CC cord-005453-4057qib7 10356 24 R+ r+ NN cord-005453-4057qib7 10356 25 group group NN cord-005453-4057qib7 10356 26 respectively respectively RB cord-005453-4057qib7 10356 27 ; ; : cord-005453-4057qib7 10356 28 p=0.37 p=0.37 NNP cord-005453-4057qib7 10356 29 . . . cord-005453-4057qib7 10357 1 Conclusions conclusion NNS cord-005453-4057qib7 10357 2 : : : cord-005453-4057qib7 10358 1 The the DT cord-005453-4057qib7 10358 2 incidence incidence NN cord-005453-4057qib7 10358 3 of of IN cord-005453-4057qib7 10358 4 recurrent recurrent JJ cord-005453-4057qib7 10358 5 CMV CMV NNP cord-005453-4057qib7 10358 6 infection infection NN cord-005453-4057qib7 10358 7 was be VBD cord-005453-4057qib7 10358 8 higher high JJR cord-005453-4057qib7 10358 9 in in IN cord-005453-4057qib7 10358 10 the the DT cord-005453-4057qib7 10358 11 D d NN cord-005453-4057qib7 10358 12 - - HYPH cord-005453-4057qib7 10358 13 R+ r+ NN cord-005453-4057qib7 10358 14 group group NN cord-005453-4057qib7 10358 15 compared compare VBN cord-005453-4057qib7 10358 16 to to IN cord-005453-4057qib7 10358 17 the the DT cord-005453-4057qib7 10358 18 D+R+ D+R+ NNP cord-005453-4057qib7 10358 19 group group NN cord-005453-4057qib7 10358 20 . . . cord-005453-4057qib7 10359 1 There there EX cord-005453-4057qib7 10359 2 were be VBD cord-005453-4057qib7 10359 3 no no DT cord-005453-4057qib7 10359 4 statistically statistically RB cord-005453-4057qib7 10359 5 significant significant JJ cord-005453-4057qib7 10359 6 differences difference NNS cord-005453-4057qib7 10359 7 between between IN cord-005453-4057qib7 10359 8 the the DT cord-005453-4057qib7 10359 9 2 2 CD cord-005453-4057qib7 10359 10 groups group NNS cord-005453-4057qib7 10359 11 in in IN cord-005453-4057qib7 10359 12 terms term NNS cord-005453-4057qib7 10359 13 of of IN cord-005453-4057qib7 10359 14 OS OS NNP cord-005453-4057qib7 10359 15 and and CC cord-005453-4057qib7 10359 16 NRM NRM NNP cord-005453-4057qib7 10359 17 . . . cord-005453-4057qib7 10360 1 However however RB cord-005453-4057qib7 10360 2 , , , cord-005453-4057qib7 10360 3 there there EX cord-005453-4057qib7 10360 4 was be VBD cord-005453-4057qib7 10360 5 a a DT cord-005453-4057qib7 10360 6 trend trend NN cord-005453-4057qib7 10360 7 towards towards IN cord-005453-4057qib7 10360 8 higher high JJR cord-005453-4057qib7 10360 9 NRM NRM NNP cord-005453-4057qib7 10360 10 in in IN cord-005453-4057qib7 10360 11 the the DT cord-005453-4057qib7 10360 12 D d NN cord-005453-4057qib7 10360 13 - - HYPH cord-005453-4057qib7 10360 14 R+ r+ NN cord-005453-4057qib7 10360 15 group group NN cord-005453-4057qib7 10360 16 compared compare VBN cord-005453-4057qib7 10360 17 to to IN cord-005453-4057qib7 10360 18 D+R+ D+R+ NNP cord-005453-4057qib7 10360 19 group group NN cord-005453-4057qib7 10360 20 . . . cord-005453-4057qib7 10361 1 Our -PRON- PRP$ cord-005453-4057qib7 10361 2 findings finding NNS cord-005453-4057qib7 10361 3 suggest suggest VBP cord-005453-4057qib7 10361 4 that that IN cord-005453-4057qib7 10361 5 for for IN cord-005453-4057qib7 10361 6 matched match VBN cord-005453-4057qib7 10361 7 unrelated unrelated JJ cord-005453-4057qib7 10361 8 HSCT HSCT NNP cord-005453-4057qib7 10361 9 , , , cord-005453-4057qib7 10361 10 it -PRON- PRP cord-005453-4057qib7 10361 11 may may MD cord-005453-4057qib7 10361 12 still still RB cord-005453-4057qib7 10361 13 be be VB cord-005453-4057qib7 10361 14 important important JJ cord-005453-4057qib7 10361 15 to to TO cord-005453-4057qib7 10361 16 select select VB cord-005453-4057qib7 10361 17 a a DT cord-005453-4057qib7 10361 18 seropositive seropositive JJ cord-005453-4057qib7 10361 19 donor donor NN cord-005453-4057qib7 10361 20 for for IN cord-005453-4057qib7 10361 21 a a DT cord-005453-4057qib7 10361 22 seropositive seropositive JJ cord-005453-4057qib7 10361 23 recipient recipient NN cord-005453-4057qib7 10361 24 . . . cord-005453-4057qib7 10362 1 Disclosure disclosure NN cord-005453-4057qib7 10362 2 : : : cord-005453-4057qib7 10363 1 None none NN cord-005453-4057qib7 10363 2 Background background NN cord-005453-4057qib7 10363 3 : : : cord-005453-4057qib7 10364 1 It´s It´s NNP cord-005453-4057qib7 10364 2 known know VBD cord-005453-4057qib7 10364 3 that that IN cord-005453-4057qib7 10364 4 some some DT cord-005453-4057qib7 10364 5 patients patient NNS cord-005453-4057qib7 10364 6 submitted submit VBN cord-005453-4057qib7 10364 7 to to IN cord-005453-4057qib7 10364 8 allogeneic allogeneic JJ cord-005453-4057qib7 10364 9 stem stem NN cord-005453-4057qib7 10364 10 cell cell NN cord-005453-4057qib7 10364 11 transplantation transplantation NN cord-005453-4057qib7 10364 12 ( ( -LRB- cord-005453-4057qib7 10364 13 ASCT ASCT NNP cord-005453-4057qib7 10364 14 ) ) -RRB- cord-005453-4057qib7 10364 15 could could MD cord-005453-4057qib7 10364 16 present present VB cord-005453-4057qib7 10364 17 a a DT cord-005453-4057qib7 10364 18 greater great JJR cord-005453-4057qib7 10364 19 susceptibility susceptibility NN cord-005453-4057qib7 10364 20 to to IN cord-005453-4057qib7 10364 21 infection infection NN cord-005453-4057qib7 10364 22 even even RB cord-005453-4057qib7 10364 23 when when WRB cord-005453-4057qib7 10364 24 they -PRON- PRP cord-005453-4057qib7 10364 25 are be VBP cord-005453-4057qib7 10364 26 in in IN cord-005453-4057qib7 10364 27 long long JJ cord-005453-4057qib7 10364 28 term term NN cord-005453-4057qib7 10364 29 complete complete JJ cord-005453-4057qib7 10364 30 remission remission NN cord-005453-4057qib7 10364 31 or or CC cord-005453-4057qib7 10364 32 potentially potentially RB cord-005453-4057qib7 10364 33 cured cure VBN cord-005453-4057qib7 10364 34 . . . cord-005453-4057qib7 10365 1 This this DT cord-005453-4057qib7 10365 2 fact fact NN cord-005453-4057qib7 10365 3 is be VBZ cord-005453-4057qib7 10365 4 related relate VBN cord-005453-4057qib7 10365 5 to to IN cord-005453-4057qib7 10365 6 the the DT cord-005453-4057qib7 10365 7 dynamic dynamic JJ cord-005453-4057qib7 10365 8 of of IN cord-005453-4057qib7 10365 9 immunological immunological JJ cord-005453-4057qib7 10365 10 recovery recovery NN cord-005453-4057qib7 10365 11 that that WDT cord-005453-4057qib7 10365 12 is be VBZ cord-005453-4057qib7 10365 13 variable variable JJ cord-005453-4057qib7 10365 14 in in IN cord-005453-4057qib7 10365 15 every every DT cord-005453-4057qib7 10365 16 single single JJ cord-005453-4057qib7 10365 17 patients patient NNS cord-005453-4057qib7 10365 18 and and CC cord-005453-4057qib7 10365 19 it -PRON- PRP cord-005453-4057qib7 10365 20 is be VBZ cord-005453-4057qib7 10365 21 dependent dependent JJ cord-005453-4057qib7 10365 22 from from IN cord-005453-4057qib7 10365 23 many many JJ cord-005453-4057qib7 10365 24 factors factor NNS cord-005453-4057qib7 10365 25 : : : cord-005453-4057qib7 10365 26 the the DT cord-005453-4057qib7 10365 27 haematological haematological JJ cord-005453-4057qib7 10365 28 disease disease NN cord-005453-4057qib7 10365 29 , , , cord-005453-4057qib7 10365 30 the the DT cord-005453-4057qib7 10365 31 conditioning conditioning NN cord-005453-4057qib7 10365 32 regimen regimen NN cord-005453-4057qib7 10365 33 , , , cord-005453-4057qib7 10365 34 the the DT cord-005453-4057qib7 10365 35 age age NN cord-005453-4057qib7 10365 36 of of IN cord-005453-4057qib7 10365 37 patient patient NN cord-005453-4057qib7 10365 38 and and CC cord-005453-4057qib7 10365 39 donor donor NN cord-005453-4057qib7 10365 40 , , , cord-005453-4057qib7 10365 41 the the DT cord-005453-4057qib7 10365 42 number number NN cord-005453-4057qib7 10365 43 of of IN cord-005453-4057qib7 10365 44 stem stem NN cord-005453-4057qib7 10365 45 cell cell NN cord-005453-4057qib7 10365 46 and and CC cord-005453-4057qib7 10365 47 lymphocytes lymphocyte NNS cord-005453-4057qib7 10365 48 infused infuse VBN cord-005453-4057qib7 10365 49 , , , cord-005453-4057qib7 10365 50 the the DT cord-005453-4057qib7 10365 51 anti anti JJ cord-005453-4057qib7 10365 52 - - JJ cord-005453-4057qib7 10365 53 GvHD gvhd JJ cord-005453-4057qib7 10365 54 prophylaxis prophylaxis NN cord-005453-4057qib7 10365 55 , , , cord-005453-4057qib7 10365 56 the the DT cord-005453-4057qib7 10365 57 use use NN cord-005453-4057qib7 10365 58 of of IN cord-005453-4057qib7 10365 59 anti anti NNS cord-005453-4057qib7 10365 60 - - NNS cord-005453-4057qib7 10365 61 Thimoglobulins Thimoglobulins NNPS cord-005453-4057qib7 10365 62 and and CC cord-005453-4057qib7 10365 63 others other NNS cord-005453-4057qib7 10365 64 . . . cord-005453-4057qib7 10366 1 In in IN cord-005453-4057qib7 10366 2 clinical clinical JJ cord-005453-4057qib7 10366 3 practise practise NN cord-005453-4057qib7 10366 4 we -PRON- PRP cord-005453-4057qib7 10366 5 can can MD cord-005453-4057qib7 10366 6 observe observe VB cord-005453-4057qib7 10366 7 patients patient NNS cord-005453-4057qib7 10366 8 who who WP cord-005453-4057qib7 10366 9 are be VBP cord-005453-4057qib7 10366 10 potentially potentially RB cord-005453-4057qib7 10366 11 cured cure VBN cord-005453-4057qib7 10366 12 , , , cord-005453-4057qib7 10366 13 who who WP cord-005453-4057qib7 10366 14 tapered taper VBD cord-005453-4057qib7 10366 15 and and CC cord-005453-4057qib7 10366 16 stopped stop VBD cord-005453-4057qib7 10366 17 the the DT cord-005453-4057qib7 10366 18 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 10366 19 treatment treatment NN cord-005453-4057qib7 10366 20 months month NNS cord-005453-4057qib7 10366 21 or or CC cord-005453-4057qib7 10366 22 years year NNS cord-005453-4057qib7 10366 23 ago ago RB cord-005453-4057qib7 10366 24 and and CC cord-005453-4057qib7 10366 25 who who WP cord-005453-4057qib7 10366 26 are be VBP cord-005453-4057qib7 10366 27 suddenly suddenly RB cord-005453-4057qib7 10366 28 graved grave VBN cord-005453-4057qib7 10366 29 from from IN cord-005453-4057qib7 10366 30 opportunistic opportunistic JJ cord-005453-4057qib7 10366 31 infections infection NNS cord-005453-4057qib7 10366 32 . . . cord-005453-4057qib7 10367 1 The the DT cord-005453-4057qib7 10367 2 largest large JJS cord-005453-4057qib7 10367 3 part part NN cord-005453-4057qib7 10367 4 of of IN cord-005453-4057qib7 10367 5 these these DT cord-005453-4057qib7 10367 6 infections infection NNS cord-005453-4057qib7 10367 7 is be VBZ cord-005453-4057qib7 10367 8 represented represent VBN cord-005453-4057qib7 10367 9 from from IN cord-005453-4057qib7 10367 10 Varicella varicella NN cord-005453-4057qib7 10367 11 - - HYPH cord-005453-4057qib7 10367 12 Zoster Zoster NNP cord-005453-4057qib7 10367 13 Virus virus NN cord-005453-4057qib7 10367 14 ( ( -LRB- cord-005453-4057qib7 10367 15 VZV VZV NNP cord-005453-4057qib7 10367 16 ) ) -RRB- cord-005453-4057qib7 10367 17 cutaneous cutaneous JJ cord-005453-4057qib7 10367 18 eruption eruption NN cord-005453-4057qib7 10367 19 . . . cord-005453-4057qib7 10368 1 Methods method NNS cord-005453-4057qib7 10368 2 : : : cord-005453-4057qib7 10368 3 In in IN cord-005453-4057qib7 10368 4 this this DT cord-005453-4057qib7 10368 5 report report NN cord-005453-4057qib7 10368 6 we -PRON- PRP cord-005453-4057qib7 10368 7 retrospectively retrospectively RB cord-005453-4057qib7 10368 8 analysed analyse VBD cord-005453-4057qib7 10368 9 a a DT cord-005453-4057qib7 10368 10 monocentric monocentric JJ cord-005453-4057qib7 10368 11 cohort cohort NN cord-005453-4057qib7 10368 12 of of IN cord-005453-4057qib7 10368 13 38 38 CD cord-005453-4057qib7 10368 14 patients patient NNS cord-005453-4057qib7 10368 15 submitted submit VBN cord-005453-4057qib7 10368 16 to to IN cord-005453-4057qib7 10368 17 ASCT ASCT NNP cord-005453-4057qib7 10368 18 for for IN cord-005453-4057qib7 10368 19 haematological haematological JJ cord-005453-4057qib7 10368 20 malignancies malignancy NNS cord-005453-4057qib7 10368 21 from from IN cord-005453-4057qib7 10368 22 a a DT cord-005453-4057qib7 10368 23 median median JJ cord-005453-4057qib7 10368 24 time time NN cord-005453-4057qib7 10368 25 of of IN cord-005453-4057qib7 10368 26 30 30 CD cord-005453-4057qib7 10368 27 months month NNS cord-005453-4057qib7 10368 28 . . . cord-005453-4057qib7 10369 1 All all DT cord-005453-4057qib7 10369 2 of of IN cord-005453-4057qib7 10369 3 them -PRON- PRP cord-005453-4057qib7 10369 4 were be VBD cord-005453-4057qib7 10369 5 free free JJ cord-005453-4057qib7 10369 6 of of IN cord-005453-4057qib7 10369 7 disease disease NN cord-005453-4057qib7 10369 8 . . . cord-005453-4057qib7 10370 1 They -PRON- PRP cord-005453-4057qib7 10370 2 stopped stop VBD cord-005453-4057qib7 10370 3 the the DT cord-005453-4057qib7 10370 4 immuno immuno JJ cord-005453-4057qib7 10370 5 - - HYPH cord-005453-4057qib7 10370 6 suppressive suppressive JJ cord-005453-4057qib7 10370 7 treatment treatment NN cord-005453-4057qib7 10370 8 in in IN cord-005453-4057qib7 10370 9 a a DT cord-005453-4057qib7 10370 10 median median JJ cord-005453-4057qib7 10370 11 time time NN cord-005453-4057qib7 10370 12 of of IN cord-005453-4057qib7 10370 13 270 270 CD cord-005453-4057qib7 10370 14 days day NNS cord-005453-4057qib7 10370 15 after after IN cord-005453-4057qib7 10370 16 ASCT ASCT NNP cord-005453-4057qib7 10370 17 ( ( -LRB- cord-005453-4057qib7 10370 18 range range NN cord-005453-4057qib7 10370 19 : : : cord-005453-4057qib7 10370 20 160 160 CD cord-005453-4057qib7 10370 21 - - HYPH cord-005453-4057qib7 10370 22 1642 1642 CD cord-005453-4057qib7 10370 23 ) ) -RRB- cord-005453-4057qib7 10370 24 and and CC cord-005453-4057qib7 10370 25 did do VBD cord-005453-4057qib7 10370 26 not not RB cord-005453-4057qib7 10370 27 present present VB cord-005453-4057qib7 10370 28 later later RBR cord-005453-4057qib7 10370 29 chronic chronic JJ cord-005453-4057qib7 10370 30 GvHD gvhd NN cord-005453-4057qib7 10370 31 needing need VBG cord-005453-4057qib7 10370 32 treatment treatment NN cord-005453-4057qib7 10370 33 neither neither CC cord-005453-4057qib7 10370 34 other other JJ cord-005453-4057qib7 10370 35 moderate moderate JJ cord-005453-4057qib7 10370 36 or or CC cord-005453-4057qib7 10370 37 severe severe JJ cord-005453-4057qib7 10370 38 chronic chronic JJ cord-005453-4057qib7 10370 39 post post NN cord-005453-4057qib7 10370 40 transplant transplant NN cord-005453-4057qib7 10370 41 complications complication NNS cord-005453-4057qib7 10370 42 nor nor CC cord-005453-4057qib7 10370 43 other other JJ cord-005453-4057qib7 10370 44 diseases disease NNS cord-005453-4057qib7 10370 45 . . . cord-005453-4057qib7 10371 1 Prophylactic prophylactic JJ cord-005453-4057qib7 10371 2 treatment treatment NN cord-005453-4057qib7 10371 3 with with IN cord-005453-4057qib7 10371 4 anti anti JJ cord-005453-4057qib7 10371 5 viral viral JJ cord-005453-4057qib7 10371 6 agents agent NNS cord-005453-4057qib7 10371 7 ( ( -LRB- cord-005453-4057qib7 10371 8 Acyclovir Acyclovir NNP cord-005453-4057qib7 10371 9 or or CC cord-005453-4057qib7 10371 10 Valacyclovir Valacyclovir NNP cord-005453-4057qib7 10371 11 ) ) -RRB- cord-005453-4057qib7 10371 12 has have VBZ cord-005453-4057qib7 10371 13 been be VBN cord-005453-4057qib7 10371 14 conducted conduct VBN cord-005453-4057qib7 10371 15 simultaneously simultaneously RB cord-005453-4057qib7 10371 16 to to IN cord-005453-4057qib7 10371 17 immuno immuno JJ cord-005453-4057qib7 10371 18 - - HYPH cord-005453-4057qib7 10371 19 suppressive suppressive JJ cord-005453-4057qib7 10371 20 treatment treatment NN cord-005453-4057qib7 10371 21 and and CC cord-005453-4057qib7 10371 22 for for IN cord-005453-4057qib7 10371 23 a a DT cord-005453-4057qib7 10371 24 period period NN cord-005453-4057qib7 10371 25 ranging range VBG cord-005453-4057qib7 10371 26 between between IN cord-005453-4057qib7 10371 27 1 1 CD cord-005453-4057qib7 10371 28 to to TO cord-005453-4057qib7 10371 29 6 6 CD cord-005453-4057qib7 10371 30 months month NNS cord-005453-4057qib7 10371 31 after after IN cord-005453-4057qib7 10371 32 its -PRON- PRP$ cord-005453-4057qib7 10371 33 suspension suspension NN cord-005453-4057qib7 10371 34 . . . cord-005453-4057qib7 10372 1 In in IN cord-005453-4057qib7 10372 2 this this DT cord-005453-4057qib7 10372 3 cohort cohort NN cord-005453-4057qib7 10372 4 of of IN cord-005453-4057qib7 10372 5 patients patient NNS cord-005453-4057qib7 10372 6 we -PRON- PRP cord-005453-4057qib7 10372 7 considered consider VBD cord-005453-4057qib7 10372 8 the the DT cord-005453-4057qib7 10372 9 incidence incidence NN cord-005453-4057qib7 10372 10 of of IN cord-005453-4057qib7 10372 11 VZV VZV NNP cord-005453-4057qib7 10372 12 eruption eruption NN cord-005453-4057qib7 10372 13 occurred occur VBD cord-005453-4057qib7 10372 14 after after IN cord-005453-4057qib7 10372 15 the the DT cord-005453-4057qib7 10372 16 suspension suspension NN cord-005453-4057qib7 10372 17 of of IN cord-005453-4057qib7 10372 18 the the DT cord-005453-4057qib7 10372 19 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 10372 20 treatment treatment NN cord-005453-4057qib7 10372 21 , , , cord-005453-4057qib7 10372 22 and and CC cord-005453-4057qib7 10372 23 we -PRON- PRP cord-005453-4057qib7 10372 24 analysed analyse VBD cord-005453-4057qib7 10372 25 the the DT cord-005453-4057qib7 10372 26 immunological immunological JJ cord-005453-4057qib7 10372 27 recovery recovery NN cord-005453-4057qib7 10372 28 in in IN cord-005453-4057qib7 10372 29 terms term NNS cord-005453-4057qib7 10372 30 of of IN cord-005453-4057qib7 10372 31 lymphocytes lymphocyte NNS cord-005453-4057qib7 10372 32 sub sub NN cord-005453-4057qib7 10372 33 - - JJ cord-005453-4057qib7 10372 34 population population NN cord-005453-4057qib7 10372 35 after after IN cord-005453-4057qib7 10372 36 6 6 CD cord-005453-4057qib7 10372 37 , , , cord-005453-4057qib7 10372 38 12 12 CD cord-005453-4057qib7 10372 39 , , , cord-005453-4057qib7 10372 40 18 18 CD cord-005453-4057qib7 10372 41 and and CC cord-005453-4057qib7 10372 42 24 24 CD cord-005453-4057qib7 10372 43 months month NNS cord-005453-4057qib7 10372 44 from from IN cord-005453-4057qib7 10372 45 ASCT ASCT NNP cord-005453-4057qib7 10372 46 . . . cord-005453-4057qib7 10373 1 Results result NNS cord-005453-4057qib7 10373 2 : : : cord-005453-4057qib7 10374 1 Of of IN cord-005453-4057qib7 10374 2 these these DT cord-005453-4057qib7 10374 3 38 38 CD cord-005453-4057qib7 10374 4 patients patient NNS cord-005453-4057qib7 10374 5 considered consider VBN cord-005453-4057qib7 10374 6 , , , cord-005453-4057qib7 10374 7 10 10 CD cord-005453-4057qib7 10374 8 developed develop VBD cord-005453-4057qib7 10374 9 at at IN cord-005453-4057qib7 10374 10 least least RBS cord-005453-4057qib7 10374 11 one one CD cord-005453-4057qib7 10374 12 VZV VZV NNP cord-005453-4057qib7 10374 13 manifestation manifestation NN cord-005453-4057qib7 10374 14 . . . cord-005453-4057qib7 10375 1 All all PDT cord-005453-4057qib7 10375 2 the the DT cord-005453-4057qib7 10375 3 VZV VZV NNP cord-005453-4057qib7 10375 4 presentation presentation NN cord-005453-4057qib7 10375 5 were be VBD cord-005453-4057qib7 10375 6 cutaneous cutaneous JJ cord-005453-4057qib7 10375 7 , , , cord-005453-4057qib7 10375 8 we -PRON- PRP cord-005453-4057qib7 10375 9 did do VBD cord-005453-4057qib7 10375 10 not not RB cord-005453-4057qib7 10375 11 observe observe VB cord-005453-4057qib7 10375 12 neurological neurological JJ cord-005453-4057qib7 10375 13 , , , cord-005453-4057qib7 10375 14 ophthalmic ophthalmic JJ cord-005453-4057qib7 10375 15 or or CC cord-005453-4057qib7 10375 16 visceral visceral JJ cord-005453-4057qib7 10375 17 presentation presentation NN cord-005453-4057qib7 10375 18 . . . cord-005453-4057qib7 10376 1 All all PDT cord-005453-4057qib7 10376 2 the the DT cord-005453-4057qib7 10376 3 VZV VZV NNP cord-005453-4057qib7 10376 4 manifestation manifestation NN cord-005453-4057qib7 10376 5 occurred occur VBD cord-005453-4057qib7 10376 6 in in IN cord-005453-4057qib7 10376 7 patients patient NNS cord-005453-4057qib7 10376 8 who who WP cord-005453-4057qib7 10376 9 ended end VBD cord-005453-4057qib7 10376 10 the the DT cord-005453-4057qib7 10376 11 anti anti JJ cord-005453-4057qib7 10376 12 - - JJ cord-005453-4057qib7 10376 13 viral viral JJ cord-005453-4057qib7 10376 14 prophylaxis prophylaxis NN cord-005453-4057qib7 10376 15 . . . cord-005453-4057qib7 10377 1 Median median JJ cord-005453-4057qib7 10377 2 time time NN cord-005453-4057qib7 10377 3 of of IN cord-005453-4057qib7 10377 4 presentation presentation NN cord-005453-4057qib7 10377 5 was be VBD cord-005453-4057qib7 10377 6 575 575 CD cord-005453-4057qib7 10377 7 days day NNS cord-005453-4057qib7 10377 8 after after IN cord-005453-4057qib7 10377 9 ASCT ASCT NNP cord-005453-4057qib7 10377 10 ( ( -LRB- cord-005453-4057qib7 10377 11 range range NN cord-005453-4057qib7 10377 12 : : : cord-005453-4057qib7 10377 13 174 174 CD cord-005453-4057qib7 10377 14 - - SYM cord-005453-4057qib7 10377 15 1642 1642 CD cord-005453-4057qib7 10377 16 ) ) -RRB- cord-005453-4057qib7 10378 1 The the DT cord-005453-4057qib7 10378 2 remaining remain VBG cord-005453-4057qib7 10378 3 28 28 CD cord-005453-4057qib7 10378 4 patients patient NNS cord-005453-4057qib7 10378 5 did do VBD cord-005453-4057qib7 10378 6 not not RB cord-005453-4057qib7 10378 7 present present VB cord-005453-4057qib7 10378 8 VZV VZV NNP cord-005453-4057qib7 10378 9 manifestation manifestation NN cord-005453-4057qib7 10378 10 nor nor CC cord-005453-4057qib7 10378 11 other other JJ cord-005453-4057qib7 10378 12 kind kind NN cord-005453-4057qib7 10378 13 of of IN cord-005453-4057qib7 10378 14 opportunistic opportunistic JJ cord-005453-4057qib7 10378 15 infection infection NN cord-005453-4057qib7 10378 16 despite despite IN cord-005453-4057qib7 10378 17 the the DT cord-005453-4057qib7 10378 18 absence absence NN cord-005453-4057qib7 10378 19 of of IN cord-005453-4057qib7 10378 20 anti anti JJ cord-005453-4057qib7 10378 21 - - JJ cord-005453-4057qib7 10378 22 viral viral JJ cord-005453-4057qib7 10378 23 prophylaxis prophylaxis NN cord-005453-4057qib7 10378 24 . . . cord-005453-4057qib7 10379 1 The the DT cord-005453-4057qib7 10379 2 analysis analysis NN cord-005453-4057qib7 10379 3 of of IN cord-005453-4057qib7 10379 4 lymphocyte lymphocyte NN cord-005453-4057qib7 10379 5 sub sub NN cord-005453-4057qib7 10379 6 - - HYPH cord-005453-4057qib7 10379 7 population population NN cord-005453-4057qib7 10379 8 after after IN cord-005453-4057qib7 10379 9 6 6 CD cord-005453-4057qib7 10379 10 - - HYPH cord-005453-4057qib7 10379 11 12 12 CD cord-005453-4057qib7 10379 12 - - SYM cord-005453-4057qib7 10379 13 18 18 CD cord-005453-4057qib7 10379 14 and and CC cord-005453-4057qib7 10379 15 24 24 CD cord-005453-4057qib7 10379 16 months month NNS cord-005453-4057qib7 10379 17 did do VBD cord-005453-4057qib7 10379 18 not not RB cord-005453-4057qib7 10379 19 show show VB cord-005453-4057qib7 10379 20 a a DT cord-005453-4057qib7 10379 21 significant significant JJ cord-005453-4057qib7 10379 22 difference difference NN cord-005453-4057qib7 10379 23 in in IN cord-005453-4057qib7 10379 24 B B NNP cord-005453-4057qib7 10379 25 , , , cord-005453-4057qib7 10379 26 T T NNP cord-005453-4057qib7 10379 27 , , , cord-005453-4057qib7 10379 28 T4 T4 NNP cord-005453-4057qib7 10379 29 , , , cord-005453-4057qib7 10379 30 T8 T8 NNP cord-005453-4057qib7 10379 31 and and CC cord-005453-4057qib7 10379 32 NK NK NNP cord-005453-4057qib7 10379 33 lymphocytes lymphocyte NNS cord-005453-4057qib7 10379 34 in in IN cord-005453-4057qib7 10379 35 the the DT cord-005453-4057qib7 10379 36 different different JJ cord-005453-4057qib7 10379 37 post post NN cord-005453-4057qib7 10379 38 transplant transplant NN cord-005453-4057qib7 10379 39 period period NN cord-005453-4057qib7 10379 40 . . . cord-005453-4057qib7 10380 1 Conclusions conclusion NNS cord-005453-4057qib7 10380 2 : : : cord-005453-4057qib7 10381 1 VZV VZV NNP cord-005453-4057qib7 10381 2 reactivation reactivation NN cord-005453-4057qib7 10381 3 seems seem VBZ cord-005453-4057qib7 10381 4 not not RB cord-005453-4057qib7 10381 5 to to TO cord-005453-4057qib7 10381 6 be be VB cord-005453-4057qib7 10381 7 correlated correlate VBN cord-005453-4057qib7 10381 8 with with IN cord-005453-4057qib7 10381 9 the the DT cord-005453-4057qib7 10381 10 number number NN cord-005453-4057qib7 10381 11 of of IN cord-005453-4057qib7 10381 12 the the DT cord-005453-4057qib7 10381 13 different different JJ cord-005453-4057qib7 10381 14 lymphocyte lymphocyte NN cord-005453-4057qib7 10381 15 subpopulations subpopulation NNS cord-005453-4057qib7 10381 16 in in IN cord-005453-4057qib7 10381 17 the the DT cord-005453-4057qib7 10381 18 post post JJ cord-005453-4057qib7 10381 19 transplant transplant NN cord-005453-4057qib7 10381 20 period period NN cord-005453-4057qib7 10381 21 . . . cord-005453-4057qib7 10382 1 Actually actually RB cord-005453-4057qib7 10382 2 it -PRON- PRP cord-005453-4057qib7 10382 3 is be VBZ cord-005453-4057qib7 10382 4 not not RB cord-005453-4057qib7 10382 5 possible possible JJ cord-005453-4057qib7 10382 6 to to TO cord-005453-4057qib7 10382 7 distinguish distinguish VB cord-005453-4057qib7 10382 8 patients patient NNS cord-005453-4057qib7 10382 9 more more RBR cord-005453-4057qib7 10382 10 suitable suitable JJ cord-005453-4057qib7 10382 11 of of IN cord-005453-4057qib7 10382 12 VZV VZV NNP cord-005453-4057qib7 10382 13 reactivation reactivation NN cord-005453-4057qib7 10382 14 on on IN cord-005453-4057qib7 10382 15 the the DT cord-005453-4057qib7 10382 16 basis basis NN cord-005453-4057qib7 10382 17 of of IN cord-005453-4057qib7 10382 18 lymphocyte lymphocyte NN cord-005453-4057qib7 10382 19 sub sub NN cord-005453-4057qib7 10382 20 - - HYPH cord-005453-4057qib7 10382 21 populations population NNS cord-005453-4057qib7 10382 22 analysis analysis NN cord-005453-4057qib7 10382 23 , , , cord-005453-4057qib7 10382 24 so so RB cord-005453-4057qib7 10382 25 anti anti JJ cord-005453-4057qib7 10382 26 - - JJ cord-005453-4057qib7 10382 27 viral viral JJ cord-005453-4057qib7 10382 28 prophylaxis prophylaxis NN cord-005453-4057qib7 10382 29 should should MD cord-005453-4057qib7 10382 30 be be VB cord-005453-4057qib7 10382 31 prolonged prolong VBN cord-005453-4057qib7 10382 32 for for IN cord-005453-4057qib7 10382 33 a a DT cord-005453-4057qib7 10382 34 medium medium JJ cord-005453-4057qib7 10382 35 period period NN cord-005453-4057qib7 10382 36 after after IN cord-005453-4057qib7 10382 37 suspension suspension NN cord-005453-4057qib7 10382 38 of of IN cord-005453-4057qib7 10382 39 immuno immuno JJ cord-005453-4057qib7 10382 40 - - JJ cord-005453-4057qib7 10382 41 suppressive suppressive JJ cord-005453-4057qib7 10382 42 drugs drug NNS cord-005453-4057qib7 10382 43 . . . cord-005453-4057qib7 10383 1 In in IN cord-005453-4057qib7 10383 2 absence absence NN cord-005453-4057qib7 10383 3 of of IN cord-005453-4057qib7 10383 4 anti anti JJ cord-005453-4057qib7 10383 5 viral viral JJ cord-005453-4057qib7 10383 6 prophylaxis prophylaxis NN cord-005453-4057qib7 10383 7 a a DT cord-005453-4057qib7 10383 8 careful careful JJ cord-005453-4057qib7 10383 9 clinical clinical JJ cord-005453-4057qib7 10383 10 surveillance surveillance NN cord-005453-4057qib7 10383 11 should should MD cord-005453-4057qib7 10383 12 be be VB cord-005453-4057qib7 10383 13 performed perform VBN cord-005453-4057qib7 10383 14 in in IN cord-005453-4057qib7 10383 15 order order NN cord-005453-4057qib7 10383 16 to to TO cord-005453-4057qib7 10383 17 treat treat VB cord-005453-4057qib7 10383 18 early early JJ cord-005453-4057qib7 10383 19 eventual eventual JJ cord-005453-4057qib7 10383 20 VZV VZV NNP cord-005453-4057qib7 10383 21 manifestations manifestation NNS cord-005453-4057qib7 10383 22 . . . cord-005453-4057qib7 10384 1 Disclosure disclosure NN cord-005453-4057qib7 10384 2 Background background NN cord-005453-4057qib7 10384 3 : : : cord-005453-4057qib7 10384 4 Infection infection NN cord-005453-4057qib7 10384 5 and and CC cord-005453-4057qib7 10384 6 disease disease NN cord-005453-4057qib7 10384 7 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 10384 8 ( ( -LRB- cord-005453-4057qib7 10384 9 CMV CMV NNP cord-005453-4057qib7 10384 10 ) ) -RRB- cord-005453-4057qib7 10384 11 are be VBP cord-005453-4057qib7 10384 12 common common JJ cord-005453-4057qib7 10384 13 problems problem NNS cord-005453-4057qib7 10384 14 in in IN cord-005453-4057qib7 10384 15 patients patient NNS cord-005453-4057qib7 10384 16 undergoing undergo VBG cord-005453-4057qib7 10384 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 10384 18 stem stem NN cord-005453-4057qib7 10384 19 cell cell NN cord-005453-4057qib7 10384 20 transplantation transplantation NN cord-005453-4057qib7 10384 21 ( ( -LRB- cord-005453-4057qib7 10384 22 HSCT HSCT NNP cord-005453-4057qib7 10384 23 ) ) -RRB- cord-005453-4057qib7 10384 24 . . . cord-005453-4057qib7 10385 1 CMV CMV NNP cord-005453-4057qib7 10385 2 infection infection NN cord-005453-4057qib7 10385 3 has have VBZ cord-005453-4057qib7 10385 4 a a DT cord-005453-4057qib7 10385 5 high high JJ cord-005453-4057qib7 10385 6 overall overall JJ cord-005453-4057qib7 10385 7 seroprevalence seroprevalence NN cord-005453-4057qib7 10385 8 , , , cord-005453-4057qib7 10385 9 therefore therefore RB cord-005453-4057qib7 10385 10 , , , cord-005453-4057qib7 10385 11 during during IN cord-005453-4057qib7 10385 12 the the DT cord-005453-4057qib7 10385 13 first first JJ cord-005453-4057qib7 10385 14 100days 100days CD cord-005453-4057qib7 10385 15 post post NN cord-005453-4057qib7 10385 16 - - JJ cord-005453-4057qib7 10385 17 HSCT HSCT NNP cord-005453-4057qib7 10385 18 , , , cord-005453-4057qib7 10385 19 it -PRON- PRP cord-005453-4057qib7 10385 20 is be VBZ cord-005453-4057qib7 10385 21 important important JJ cord-005453-4057qib7 10385 22 to to TO cord-005453-4057qib7 10385 23 prevent prevent VB cord-005453-4057qib7 10385 24 reactivation reactivation NN cord-005453-4057qib7 10385 25 of of IN cord-005453-4057qib7 10385 26 CMV CMV NNP cord-005453-4057qib7 10385 27 . . . cord-005453-4057qib7 10386 1 The the DT cord-005453-4057qib7 10386 2 international international JJ cord-005453-4057qib7 10386 3 clinical clinical JJ cord-005453-4057qib7 10386 4 recommendation recommendation NN cord-005453-4057qib7 10386 5 is be VBZ cord-005453-4057qib7 10386 6 the the DT cord-005453-4057qib7 10386 7 use use NN cord-005453-4057qib7 10386 8 of of IN cord-005453-4057qib7 10386 9 ganciclovir ganciclovir NNP cord-005453-4057qib7 10386 10 as as IN cord-005453-4057qib7 10386 11 prophylaxis prophylaxis NN cord-005453-4057qib7 10386 12 in in IN cord-005453-4057qib7 10386 13 HSCT HSCT NNP cord-005453-4057qib7 10386 14 patients patient NNS cord-005453-4057qib7 10386 15 ; ; : cord-005453-4057qib7 10386 16 however however RB cord-005453-4057qib7 10386 17 , , , cord-005453-4057qib7 10386 18 the the DT cord-005453-4057qib7 10386 19 cost cost NN cord-005453-4057qib7 10386 20 of of IN cord-005453-4057qib7 10386 21 this this DT cord-005453-4057qib7 10386 22 treatment treatment NN cord-005453-4057qib7 10386 23 is be VBZ cord-005453-4057qib7 10386 24 not not RB cord-005453-4057qib7 10386 25 accessible accessible JJ cord-005453-4057qib7 10386 26 for for IN cord-005453-4057qib7 10386 27 our -PRON- PRP$ cord-005453-4057qib7 10386 28 population population NN cord-005453-4057qib7 10386 29 . . . cord-005453-4057qib7 10387 1 In in IN cord-005453-4057qib7 10387 2 this this DT cord-005453-4057qib7 10387 3 respect respect NN cord-005453-4057qib7 10387 4 it -PRON- PRP cord-005453-4057qib7 10387 5 has have VBZ cord-005453-4057qib7 10387 6 been be VBN cord-005453-4057qib7 10387 7 used use VBN cord-005453-4057qib7 10387 8 as as IN cord-005453-4057qib7 10387 9 an an DT cord-005453-4057qib7 10387 10 alternative alternative JJ cord-005453-4057qib7 10387 11 Valganciclovir Valganciclovir NNPS cord-005453-4057qib7 10387 12 because because IN cord-005453-4057qib7 10387 13 of of IN cord-005453-4057qib7 10387 14 its -PRON- PRP$ cord-005453-4057qib7 10387 15 lower low JJR cord-005453-4057qib7 10387 16 cost cost NN cord-005453-4057qib7 10387 17 and and CC cord-005453-4057qib7 10387 18 oral oral JJ cord-005453-4057qib7 10387 19 administration administration NN cord-005453-4057qib7 10387 20 . . . cord-005453-4057qib7 10388 1 Our -PRON- PRP$ cord-005453-4057qib7 10388 2 study´s study´s NNP cord-005453-4057qib7 10388 3 aim aim NN cord-005453-4057qib7 10388 4 was be VBD cord-005453-4057qib7 10388 5 to to TO cord-005453-4057qib7 10388 6 assess assess VB cord-005453-4057qib7 10388 7 the the DT cord-005453-4057qib7 10388 8 response response NN cord-005453-4057qib7 10388 9 and and CC cord-005453-4057qib7 10388 10 safety safety NN cord-005453-4057qib7 10388 11 of of IN cord-005453-4057qib7 10388 12 valganciclovir valganciclovir NNP cord-005453-4057qib7 10388 13 in in IN cord-005453-4057qib7 10388 14 comparison comparison NN cord-005453-4057qib7 10388 15 with with IN cord-005453-4057qib7 10388 16 ganciclovir ganciclovir NNP cord-005453-4057qib7 10388 17 to to TO cord-005453-4057qib7 10388 18 prevent prevent VB cord-005453-4057qib7 10388 19 viremia viremia NN cord-005453-4057qib7 10388 20 and and CC cord-005453-4057qib7 10388 21 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 10388 22 disease disease NN cord-005453-4057qib7 10388 23 in in IN cord-005453-4057qib7 10388 24 patients patient NNS cord-005453-4057qib7 10388 25 undergoing undergo VBG cord-005453-4057qib7 10388 26 allogeneic allogeneic IN cord-005453-4057qib7 10388 27 HSCT HSCT NNP cord-005453-4057qib7 10388 28 Methods Methods NNPS cord-005453-4057qib7 10388 29 : : : cord-005453-4057qib7 10388 30 A a DT cord-005453-4057qib7 10388 31 retrospective retrospective JJ cord-005453-4057qib7 10388 32 study study NN cord-005453-4057qib7 10388 33 was be VBD cord-005453-4057qib7 10388 34 performed perform VBN cord-005453-4057qib7 10388 35 on on IN cord-005453-4057qib7 10388 36 patients patient NNS cord-005453-4057qib7 10388 37 who who WP cord-005453-4057qib7 10388 38 receive receive VBP cord-005453-4057qib7 10388 39 an an DT cord-005453-4057qib7 10388 40 HSCT HSCT NNP cord-005453-4057qib7 10388 41 - - HYPH cord-005453-4057qib7 10388 42 allo allo NN cord-005453-4057qib7 10388 43 between between IN cord-005453-4057qib7 10388 44 January January NNP cord-005453-4057qib7 10388 45 2014 2014 CD cord-005453-4057qib7 10388 46 and and CC cord-005453-4057qib7 10388 47 August August NNP cord-005453-4057qib7 10388 48 2018 2018 CD cord-005453-4057qib7 10388 49 . . . cord-005453-4057qib7 10389 1 Participants participant NNS cord-005453-4057qib7 10389 2 were be VBD cord-005453-4057qib7 10389 3 enrolled enrol VBN cord-005453-4057qib7 10389 4 in in IN cord-005453-4057qib7 10389 5 two two CD cord-005453-4057qib7 10389 6 groups group NNS cord-005453-4057qib7 10389 7 according accord VBG cord-005453-4057qib7 10389 8 to to IN cord-005453-4057qib7 10389 9 prophylaxis prophylaxis NN cord-005453-4057qib7 10389 10 treatment treatment NN cord-005453-4057qib7 10389 11 : : : cord-005453-4057qib7 10390 1 ( ( -LRB- cord-005453-4057qib7 10390 2 a a LS cord-005453-4057qib7 10390 3 ) ) -RRB- cord-005453-4057qib7 10390 4 ganciclovir ganciclovir NNP cord-005453-4057qib7 10390 5 5mg/ 5mg/ CD cord-005453-4057qib7 10391 1 k k NNP cord-005453-4057qib7 10392 1 once once RB cord-005453-4057qib7 10392 2 daily daily RB cord-005453-4057qib7 10392 3 and and CC cord-005453-4057qib7 10392 4 ( ( -LRB- cord-005453-4057qib7 10392 5 b b NN cord-005453-4057qib7 10392 6 ) ) -RRB- cord-005453-4057qib7 10392 7 valganciclovir valganciclovir VBZ cord-005453-4057qib7 10392 8 450 450 CD cord-005453-4057qib7 10392 9 mg mg NNS cord-005453-4057qib7 10392 10 twice twice RB cord-005453-4057qib7 10392 11 daily daily RB cord-005453-4057qib7 10392 12 for for IN cord-005453-4057qib7 10392 13 7 7 CD cord-005453-4057qib7 10392 14 days day NNS cord-005453-4057qib7 10392 15 pretransplant pretransplant NN cord-005453-4057qib7 10392 16 , , , cord-005453-4057qib7 10392 17 at at IN cord-005453-4057qib7 10392 18 day day NN cord-005453-4057qib7 10392 19 +100 +100 NNS cord-005453-4057qib7 10392 20 ; ; : cord-005453-4057qib7 10392 21 viremia viremia NNP cord-005453-4057qib7 10392 22 was be VBD cord-005453-4057qib7 10392 23 measured measure VBN cord-005453-4057qib7 10392 24 by by IN cord-005453-4057qib7 10392 25 PCR PCR NNP cord-005453-4057qib7 10392 26 . . . cord-005453-4057qib7 10393 1 Demographic demographic JJ cord-005453-4057qib7 10393 2 and and CC cord-005453-4057qib7 10393 3 clinical clinical JJ cord-005453-4057qib7 10393 4 information information NN cord-005453-4057qib7 10393 5 was be VBD cord-005453-4057qib7 10393 6 collected collect VBN cord-005453-4057qib7 10393 7 from from IN cord-005453-4057qib7 10393 8 medical medical JJ cord-005453-4057qib7 10393 9 records record NNS cord-005453-4057qib7 10393 10 and and CC cord-005453-4057qib7 10393 11 furthermore furthermore RB cord-005453-4057qib7 10393 12 analyzed analyze VBN cord-005453-4057qib7 10393 13 in in IN cord-005453-4057qib7 10393 14 SPSS SPSS NNP cord-005453-4057qib7 10393 15 v21 v21 NN cord-005453-4057qib7 10393 16 . . . cord-005453-4057qib7 10394 1 Results result NNS cord-005453-4057qib7 10394 2 : : : cord-005453-4057qib7 10394 3 Sixty sixty CD cord-005453-4057qib7 10394 4 - - HYPH cord-005453-4057qib7 10394 5 eight eight CD cord-005453-4057qib7 10394 6 patients patient NNS cord-005453-4057qib7 10394 7 were be VBD cord-005453-4057qib7 10394 8 enrolled enrol VBN cord-005453-4057qib7 10394 9 in in IN cord-005453-4057qib7 10394 10 the the DT cord-005453-4057qib7 10394 11 study study NN cord-005453-4057qib7 10394 12 , , , cord-005453-4057qib7 10394 13 54 54 CD cord-005453-4057qib7 10394 14 % % NN cord-005453-4057qib7 10394 15 male male NN cord-005453-4057qib7 10394 16 , , , cord-005453-4057qib7 10394 17 the the DT cord-005453-4057qib7 10394 18 median median JJ cord-005453-4057qib7 10394 19 age age NN cord-005453-4057qib7 10394 20 was be VBD cord-005453-4057qib7 10394 21 34 34 CD cord-005453-4057qib7 10394 22 years year NNS cord-005453-4057qib7 10394 23 ( ( -LRB- cord-005453-4057qib7 10394 24 19 19 CD cord-005453-4057qib7 10394 25 - - SYM cord-005453-4057qib7 10394 26 61 61 CD cord-005453-4057qib7 10394 27 ) ) -RRB- cord-005453-4057qib7 10394 28 with with IN cord-005453-4057qib7 10394 29 the the DT cord-005453-4057qib7 10394 30 following follow VBG cord-005453-4057qib7 10394 31 diagnoses diagnosis NNS cord-005453-4057qib7 10395 1 : : : cord-005453-4057qib7 10395 2 acute acute JJ cord-005453-4057qib7 10395 3 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 10395 4 leukemia leukemia NN cord-005453-4057qib7 10395 5 44 44 CD cord-005453-4057qib7 10395 6 % % NN cord-005453-4057qib7 10395 7 , , , cord-005453-4057qib7 10395 8 acute acute JJ cord-005453-4057qib7 10395 9 myeloblastic myeloblastic JJ cord-005453-4057qib7 10395 10 leukemia leukemia NN cord-005453-4057qib7 10395 11 26.5 26.5 CD cord-005453-4057qib7 10395 12 % % NN cord-005453-4057qib7 10395 13 , , , cord-005453-4057qib7 10395 14 granulocytic granulocytic JJ cord-005453-4057qib7 10395 15 chronic chronic JJ cord-005453-4057qib7 10395 16 leukemia leukemia NN cord-005453-4057qib7 10395 17 17.6 17.6 CD cord-005453-4057qib7 10395 18 % % NN cord-005453-4057qib7 10395 19 , , , cord-005453-4057qib7 10395 20 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 10395 21 syndrome syndrome NN cord-005453-4057qib7 10395 22 4.4 4.4 CD cord-005453-4057qib7 10395 23 % % NN cord-005453-4057qib7 10395 24 , , , cord-005453-4057qib7 10395 25 dendritic dendritic JJ cord-005453-4057qib7 10395 26 cell cell NN cord-005453-4057qib7 10395 27 neoplasia neoplasia NN cord-005453-4057qib7 10395 28 4.4 4.4 CD cord-005453-4057qib7 10395 29 % % NN cord-005453-4057qib7 10395 30 , , , cord-005453-4057qib7 10395 31 and and CC cord-005453-4057qib7 10395 32 aplastic aplastic JJ cord-005453-4057qib7 10395 33 anemia anemia NN cord-005453-4057qib7 10395 34 2.9 2.9 CD cord-005453-4057qib7 10395 35 % % NN cord-005453-4057qib7 10395 36 . . . cord-005453-4057qib7 10396 1 Ninety ninety CD cord-005453-4057qib7 10396 2 - - HYPH cord-005453-4057qib7 10396 3 one one CD cord-005453-4057qib7 10396 4 percet percet NNS cord-005453-4057qib7 10396 5 of of IN cord-005453-4057qib7 10396 6 the the DT cord-005453-4057qib7 10396 7 patients patient NNS cord-005453-4057qib7 10396 8 received receive VBD cord-005453-4057qib7 10396 9 a a DT cord-005453-4057qib7 10396 10 transplant transplant NN cord-005453-4057qib7 10396 11 from from IN cord-005453-4057qib7 10396 12 an an DT cord-005453-4057qib7 10396 13 identical identical JJ cord-005453-4057qib7 10396 14 HLA HLA NNP cord-005453-4057qib7 10396 15 donor donor NN cord-005453-4057qib7 10396 16 and and CC cord-005453-4057qib7 10396 17 8.8 8.8 CD cord-005453-4057qib7 10396 18 % % NN cord-005453-4057qib7 10396 19 received receive VBD cord-005453-4057qib7 10396 20 a a DT cord-005453-4057qib7 10396 21 haploidentical haploidentical JJ cord-005453-4057qib7 10396 22 transplant transplant NN cord-005453-4057qib7 10396 23 . . . cord-005453-4057qib7 10397 1 Thirty thirty CD cord-005453-4057qib7 10397 2 - - HYPH cord-005453-4057qib7 10397 3 four four CD cord-005453-4057qib7 10397 4 patients patient NNS cord-005453-4057qib7 10397 5 received receive VBD cord-005453-4057qib7 10397 6 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 10397 7 ( ( -LRB- cord-005453-4057qib7 10397 8 G1 G1 NNP cord-005453-4057qib7 10397 9 ) ) -RRB- cord-005453-4057qib7 10397 10 and and CC cord-005453-4057qib7 10397 11 thirtyfour thirtyfour NNP cord-005453-4057qib7 10397 12 Valganciclovir Valganciclovir NNP cord-005453-4057qib7 10397 13 ( ( -LRB- cord-005453-4057qib7 10397 14 G2 G2 NNP cord-005453-4057qib7 10397 15 ) ) -RRB- cord-005453-4057qib7 10397 16 . . . cord-005453-4057qib7 10398 1 Median median JJ cord-005453-4057qib7 10398 2 age age NN cord-005453-4057qib7 10398 3 was be VBD cord-005453-4057qib7 10398 4 39 39 CD cord-005453-4057qib7 10398 5 vs28 vs28 NNP cord-005453-4057qib7 10398 6 years year NNS cord-005453-4057qib7 10398 7 ( ( -LRB- cord-005453-4057qib7 10398 8 p=0.022 p=0.022 NNP cord-005453-4057qib7 10398 9 ) ) -RRB- cord-005453-4057qib7 10398 10 , , , cord-005453-4057qib7 10398 11 intermediate intermediate JJ cord-005453-4057qib7 10398 12 risk risk NN cord-005453-4057qib7 10398 13 CMV CMV NNP cord-005453-4057qib7 10398 14 85 85 CD cord-005453-4057qib7 10398 15 % % NN cord-005453-4057qib7 10398 16 vs vs IN cord-005453-4057qib7 10398 17 76 76 CD cord-005453-4057qib7 10398 18 ( ( -LRB- cord-005453-4057qib7 10398 19 p=0.048 p=0.048 NNP cord-005453-4057qib7 10398 20 ) ) -RRB- cord-005453-4057qib7 10398 21 , , , cord-005453-4057qib7 10398 22 associated associate VBN cord-005453-4057qib7 10398 23 bacterial bacterial JJ cord-005453-4057qib7 10398 24 infections infection NNS cord-005453-4057qib7 10398 25 was be VBD cord-005453-4057qib7 10398 26 15%vs 15%v VBN cord-005453-4057qib7 10398 27 32 32 CD cord-005453-4057qib7 10398 28 % % NN cord-005453-4057qib7 10398 29 ( ( -LRB- cord-005453-4057qib7 10398 30 p=0.15 p=0.15 NNP cord-005453-4057qib7 10398 31 ) ) -RRB- cord-005453-4057qib7 10398 32 , , , cord-005453-4057qib7 10398 33 and and CC cord-005453-4057qib7 10398 34 fungal fungal JJ cord-005453-4057qib7 10398 35 infections infection NNS cord-005453-4057qib7 10398 36 6 6 CD cord-005453-4057qib7 10398 37 % % NN cord-005453-4057qib7 10398 38 vs9 vs9 NN cord-005453-4057qib7 10398 39 % % NN cord-005453-4057qib7 10398 40 respectively respectively RB cord-005453-4057qib7 10398 41 ( ( -LRB- cord-005453-4057qib7 10398 42 p=0.5 p=0.5 NNP cord-005453-4057qib7 10398 43 ) ) -RRB- cord-005453-4057qib7 10398 44 . . . cord-005453-4057qib7 10399 1 The the DT cord-005453-4057qib7 10399 2 reactivation reactivation NN cord-005453-4057qib7 10399 3 by by IN cord-005453-4057qib7 10399 4 CMV CMV NNP cord-005453-4057qib7 10399 5 was be VBD cord-005453-4057qib7 10399 6 presented present VBN cord-005453-4057qib7 10399 7 in in IN cord-005453-4057qib7 10399 8 21 21 CD cord-005453-4057qib7 10399 9 % % NN cord-005453-4057qib7 10399 10 vs vs IN cord-005453-4057qib7 10399 11 15 15 CD cord-005453-4057qib7 10399 12 % % NN cord-005453-4057qib7 10399 13 respectively respectively RB cord-005453-4057qib7 10399 14 ( ( -LRB- cord-005453-4057qib7 10399 15 p=0.70 p=0.70 NN cord-005453-4057qib7 10399 16 ) ) -RRB- cord-005453-4057qib7 10399 17 . . . cord-005453-4057qib7 10400 1 There there EX cord-005453-4057qib7 10400 2 were be VBD cord-005453-4057qib7 10400 3 no no DT cord-005453-4057qib7 10400 4 significant significant JJ cord-005453-4057qib7 10400 5 differences difference NNS cord-005453-4057qib7 10400 6 in in IN cord-005453-4057qib7 10400 7 fever fever NN cord-005453-4057qib7 10400 8 , , , cord-005453-4057qib7 10400 9 bacterial bacterial JJ cord-005453-4057qib7 10400 10 isolation isolation NN cord-005453-4057qib7 10400 11 , , , cord-005453-4057qib7 10400 12 dysfunction dysfunction NN cord-005453-4057qib7 10400 13 or or CC cord-005453-4057qib7 10400 14 graft graft NN cord-005453-4057qib7 10400 15 failure failure NN cord-005453-4057qib7 10400 16 , , , cord-005453-4057qib7 10400 17 presence presence NN cord-005453-4057qib7 10400 18 and and CC cord-005453-4057qib7 10400 19 degree degree NN cord-005453-4057qib7 10400 20 of of IN cord-005453-4057qib7 10400 21 acute acute JJ cord-005453-4057qib7 10400 22 or or CC cord-005453-4057qib7 10400 23 chronic chronic JJ cord-005453-4057qib7 10400 24 GVHD GVHD NNP cord-005453-4057qib7 10400 25 and and CC cord-005453-4057qib7 10400 26 relapse relapse NN cord-005453-4057qib7 10400 27 of of IN cord-005453-4057qib7 10400 28 the the DT cord-005453-4057qib7 10400 29 disease disease NN cord-005453-4057qib7 10400 30 . . . cord-005453-4057qib7 10401 1 The the DT cord-005453-4057qib7 10401 2 most most RBS cord-005453-4057qib7 10401 3 relevant relevant JJ cord-005453-4057qib7 10401 4 characteristics characteristic NNS cord-005453-4057qib7 10401 5 and and CC cord-005453-4057qib7 10401 6 complications complication NNS cord-005453-4057qib7 10401 7 are be VBP cord-005453-4057qib7 10401 8 described describe VBN cord-005453-4057qib7 10401 9 in in IN cord-005453-4057qib7 10401 10 table table NN cord-005453-4057qib7 10401 11 1 1 CD cord-005453-4057qib7 10401 12 . . . cord-005453-4057qib7 10402 1 Within within IN cord-005453-4057qib7 10402 2 the the DT cord-005453-4057qib7 10402 3 whole whole JJ cord-005453-4057qib7 10402 4 group group NN cord-005453-4057qib7 10402 5 there there EX cord-005453-4057qib7 10402 6 were be VBD cord-005453-4057qib7 10402 7 28 28 CD cord-005453-4057qib7 10402 8 deaths death NNS cord-005453-4057qib7 10402 9 , , , cord-005453-4057qib7 10402 10 53 53 CD cord-005453-4057qib7 10402 11 % % NN cord-005453-4057qib7 10402 12 in in IN cord-005453-4057qib7 10402 13 the the DT cord-005453-4057qib7 10402 14 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 10402 15 group group NN cord-005453-4057qib7 10402 16 and and CC cord-005453-4057qib7 10402 17 32 32 CD cord-005453-4057qib7 10402 18 % % NN cord-005453-4057qib7 10402 19 in in IN cord-005453-4057qib7 10402 20 Valganciclovir Valganciclovir NNP cord-005453-4057qib7 10402 21 group group NN cord-005453-4057qib7 10402 22 ( ( -LRB- cord-005453-4057qib7 10402 23 p=0.14 p=0.14 NNP cord-005453-4057qib7 10402 24 ) ) -RRB- cord-005453-4057qib7 10402 25 , , , cord-005453-4057qib7 10402 26 overall overall JJ cord-005453-4057qib7 10402 27 survival survival NN cord-005453-4057qib7 10402 28 1-year 1-year CD cord-005453-4057qib7 10402 29 was be VBD cord-005453-4057qib7 10402 30 66 66 CD cord-005453-4057qib7 10402 31 % % NN cord-005453-4057qib7 10402 32 vs vs IN cord-005453-4057qib7 10402 33 80 80 CD cord-005453-4057qib7 10402 34 % % NN cord-005453-4057qib7 10403 1 ( ( -LRB- cord-005453-4057qib7 10403 2 p=0.58 p=0.58 JJ cord-005453-4057qib7 10403 3 ) ) -RRB- cord-005453-4057qib7 10403 4 respectively respectively RB cord-005453-4057qib7 10404 1 ; ; : cord-005453-4057qib7 10404 2 in in IN cord-005453-4057qib7 10404 3 both both DT cord-005453-4057qib7 10404 4 groups group NNS cord-005453-4057qib7 10404 5 72 72 CD cord-005453-4057qib7 10404 6 % % NN cord-005453-4057qib7 10404 7 was be VBD cord-005453-4057qib7 10404 8 associated associate VBN cord-005453-4057qib7 10404 9 with with IN cord-005453-4057qib7 10404 10 relapse relapse NN cord-005453-4057qib7 10404 11 and and CC cord-005453-4057qib7 10404 12 28 28 CD cord-005453-4057qib7 10404 13 % % NN cord-005453-4057qib7 10404 14 associated associate VBN cord-005453-4057qib7 10404 15 with with IN cord-005453-4057qib7 10404 16 transplantation transplantation NN cord-005453-4057qib7 10404 17 . . . cord-005453-4057qib7 10405 1 Conclusions conclusion NNS cord-005453-4057qib7 10405 2 : : : cord-005453-4057qib7 10406 1 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 10406 2 and and CC cord-005453-4057qib7 10406 3 Valganciclovir Valganciclovir NNPS cord-005453-4057qib7 10406 4 were be VBD cord-005453-4057qib7 10406 5 effective effective JJ cord-005453-4057qib7 10406 6 in in IN cord-005453-4057qib7 10406 7 preventing prevent VBG cord-005453-4057qib7 10406 8 the the DT cord-005453-4057qib7 10406 9 reactivation reactivation NN cord-005453-4057qib7 10406 10 of of IN cord-005453-4057qib7 10406 11 CMV CMV NNP cord-005453-4057qib7 10406 12 , , , cord-005453-4057qib7 10406 13 the the DT cord-005453-4057qib7 10406 14 only only JJ cord-005453-4057qib7 10406 15 statistically statistically RB cord-005453-4057qib7 10406 16 significant significant JJ cord-005453-4057qib7 10406 17 difference difference NN cord-005453-4057qib7 10407 1 was be VBD cord-005453-4057qib7 10407 2 that that IN cord-005453-4057qib7 10407 3 the the DT cord-005453-4057qib7 10407 4 presentation presentation NN cord-005453-4057qib7 10407 5 of of IN cord-005453-4057qib7 10407 6 the the DT cord-005453-4057qib7 10407 7 disease disease NN cord-005453-4057qib7 10407 8 appeared appear VBD cord-005453-4057qib7 10407 9 earlier early RBR cord-005453-4057qib7 10407 10 in in IN cord-005453-4057qib7 10407 11 the the DT cord-005453-4057qib7 10407 12 Valganciclovir Valganciclovir NNP cord-005453-4057qib7 10407 13 group group NN cord-005453-4057qib7 10407 14 . . . cord-005453-4057qib7 10408 1 No no DT cord-005453-4057qib7 10408 2 difference difference NN cord-005453-4057qib7 10408 3 in in IN cord-005453-4057qib7 10408 4 toxicity toxicity NN cord-005453-4057qib7 10408 5 between between IN cord-005453-4057qib7 10408 6 the the DT cord-005453-4057qib7 10408 7 groups group NNS cord-005453-4057qib7 10408 8 was be VBD cord-005453-4057qib7 10408 9 identified identify VBN cord-005453-4057qib7 10408 10 . . . cord-005453-4057qib7 10409 1 Disclosure disclosure NN cord-005453-4057qib7 10409 2 : : : cord-005453-4057qib7 10410 1 None none NN cord-005453-4057qib7 10410 2 declared declare VBD cord-005453-4057qib7 10410 3 Background background NN cord-005453-4057qib7 10410 4 : : : cord-005453-4057qib7 10411 1 Invasive invasive JJ cord-005453-4057qib7 10411 2 pulmonary pulmonary JJ cord-005453-4057qib7 10411 3 aspergillosis aspergillosis NN cord-005453-4057qib7 10411 4 ( ( -LRB- cord-005453-4057qib7 10411 5 IPA IPA NNP cord-005453-4057qib7 10411 6 ) ) -RRB- cord-005453-4057qib7 10411 7 is be VBZ cord-005453-4057qib7 10411 8 a a DT cord-005453-4057qib7 10411 9 severe severe JJ cord-005453-4057qib7 10411 10 and and CC cord-005453-4057qib7 10411 11 serious serious JJ cord-005453-4057qib7 10411 12 complication complication NN cord-005453-4057qib7 10411 13 that that WDT cord-005453-4057qib7 10411 14 occurs occur VBZ cord-005453-4057qib7 10411 15 in in IN cord-005453-4057qib7 10411 16 the the DT cord-005453-4057qib7 10411 17 immediate immediate JJ cord-005453-4057qib7 10411 18 post post JJ cord-005453-4057qib7 10411 19 - - JJ cord-005453-4057qib7 10411 20 transplant transplant JJ cord-005453-4057qib7 10411 21 period period NN cord-005453-4057qib7 10411 22 due due IN cord-005453-4057qib7 10411 23 to to IN cord-005453-4057qib7 10411 24 severe severe JJ cord-005453-4057qib7 10411 25 neutropenia neutropenia NN cord-005453-4057qib7 10411 26 or or CC cord-005453-4057qib7 10411 27 late late RB cord-005453-4057qib7 10411 28 usually usually RB cord-005453-4057qib7 10411 29 following follow VBG cord-005453-4057qib7 10411 30 prolonged prolong VBN cord-005453-4057qib7 10411 31 corticosteroid corticosteroid NN cord-005453-4057qib7 10411 32 therapy therapy NN cord-005453-4057qib7 10411 33 during during IN cord-005453-4057qib7 10411 34 treatment treatment NN cord-005453-4057qib7 10411 35 of of IN cord-005453-4057qib7 10411 36 graft graft NN cord-005453-4057qib7 10411 37 - - HYPH cord-005453-4057qib7 10411 38 versus versus IN cord-005453-4057qib7 10411 39 - - HYPH cord-005453-4057qib7 10411 40 host host NN cord-005453-4057qib7 10411 41 disease disease NN cord-005453-4057qib7 10411 42 ( ( -LRB- cord-005453-4057qib7 10411 43 GVHD GVHD NNP cord-005453-4057qib7 10411 44 ) ) -RRB- cord-005453-4057qib7 10411 45 . . . cord-005453-4057qib7 10412 1 The the DT cord-005453-4057qib7 10412 2 objective objective NN cord-005453-4057qib7 10412 3 of of IN cord-005453-4057qib7 10412 4 this this DT cord-005453-4057qib7 10412 5 study study NN cord-005453-4057qib7 10412 6 is be VBZ cord-005453-4057qib7 10412 7 to to TO cord-005453-4057qib7 10412 8 analyze analyze VB cord-005453-4057qib7 10412 9 the the DT cord-005453-4057qib7 10412 10 epidemiological epidemiological JJ cord-005453-4057qib7 10412 11 , , , cord-005453-4057qib7 10412 12 diagnostic diagnostic JJ cord-005453-4057qib7 10412 13 and and CC cord-005453-4057qib7 10412 14 evolutionary evolutionary JJ cord-005453-4057qib7 10412 15 characteristics characteristic NNS cord-005453-4057qib7 10412 16 of of IN cord-005453-4057qib7 10412 17 this this DT cord-005453-4057qib7 10412 18 major major JJ cord-005453-4057qib7 10412 19 complication complication NN cord-005453-4057qib7 10412 20 over over IN cord-005453-4057qib7 10412 21 a a DT cord-005453-4057qib7 10412 22 period period NN cord-005453-4057qib7 10412 23 of of IN cord-005453-4057qib7 10412 24 3 3 CD cord-005453-4057qib7 10412 25 years year NNS cord-005453-4057qib7 10412 26 . . . cord-005453-4057qib7 10413 1 Methods method NNS cord-005453-4057qib7 10413 2 : : : cord-005453-4057qib7 10413 3 From from IN cord-005453-4057qib7 10413 4 January January NNP cord-005453-4057qib7 10413 5 2015 2015 CD cord-005453-4057qib7 10413 6 to to IN cord-005453-4057qib7 10413 7 December December NNP cord-005453-4057qib7 10413 8 2017 2017 CD cord-005453-4057qib7 10413 9 , , , cord-005453-4057qib7 10413 10 392 392 CD cord-005453-4057qib7 10413 11 patients patient NNS cord-005453-4057qib7 10413 12 ( ( -LRB- cord-005453-4057qib7 10413 13 pts pts NNP cord-005453-4057qib7 10413 14 ) ) -RRB- cord-005453-4057qib7 10413 15 received receive VBD cord-005453-4057qib7 10413 16 an an DT cord-005453-4057qib7 10413 17 allogeneic allogeneic JJ cord-005453-4057qib7 10413 18 hematopoietic hematopoietic JJ cord-005453-4057qib7 10413 19 stem stem NN cord-005453-4057qib7 10413 20 cell cell NN cord-005453-4057qib7 10413 21 transplantation transplantation NN cord-005453-4057qib7 10413 22 ( ( -LRB- cord-005453-4057qib7 10413 23 allo allo NNP cord-005453-4057qib7 10413 24 HSCT HSCT NNP cord-005453-4057qib7 10413 25 ) ) -RRB- cord-005453-4057qib7 10413 26 for for IN cord-005453-4057qib7 10413 27 malignant malignant JJ cord-005453-4057qib7 10413 28 and and CC cord-005453-4057qib7 10413 29 nonmalignant nonmalignant JJ cord-005453-4057qib7 10413 30 haematological haematological JJ cord-005453-4057qib7 10413 31 diseases disease NNS cord-005453-4057qib7 10413 32 . . . cord-005453-4057qib7 10414 1 During during IN cord-005453-4057qib7 10414 2 the the DT cord-005453-4057qib7 10414 3 transplant transplant NN cord-005453-4057qib7 10414 4 procedure procedure NN cord-005453-4057qib7 10414 5 , , , cord-005453-4057qib7 10414 6 anti anti JJ cord-005453-4057qib7 10414 7 - - JJ cord-005453-4057qib7 10414 8 infectious infectious JJ cord-005453-4057qib7 10414 9 prophylaxis prophylaxis NN cord-005453-4057qib7 10414 10 consisted consist VBD cord-005453-4057qib7 10414 11 of of IN cord-005453-4057qib7 10414 12 pts pts NN cord-005453-4057qib7 10414 13 isolation isolation NN cord-005453-4057qib7 10414 14 , , , cord-005453-4057qib7 10414 15 digestive digestive JJ cord-005453-4057qib7 10414 16 decontamination decontamination NN cord-005453-4057qib7 10414 17 , , , cord-005453-4057qib7 10414 18 Fluconazole Fluconazole NNP cord-005453-4057qib7 10414 19 and and CC cord-005453-4057qib7 10414 20 Aciclovir Aciclovir NNP cord-005453-4057qib7 10414 21 . . . cord-005453-4057qib7 10415 1 Secondary secondary JJ cord-005453-4057qib7 10415 2 prophylaxis prophylaxis NN cord-005453-4057qib7 10415 3 done do VBN cord-005453-4057qib7 10415 4 for for IN cord-005453-4057qib7 10415 5 pts pt NNS cord-005453-4057qib7 10415 6 with with IN cord-005453-4057qib7 10415 7 prior prior JJ cord-005453-4057qib7 10415 8 history history NN cord-005453-4057qib7 10415 9 aspergillosis aspergillosis NN cord-005453-4057qib7 10415 10 . . . cord-005453-4057qib7 10416 1 During during IN cord-005453-4057qib7 10416 2 the the DT cord-005453-4057qib7 10416 3 follow follow NN cord-005453-4057qib7 10416 4 - - HYPH cord-005453-4057qib7 10416 5 up up NN cord-005453-4057qib7 10416 6 , , , cord-005453-4057qib7 10416 7 a a DT cord-005453-4057qib7 10416 8 standard standard JJ cord-005453-4057qib7 10416 9 chest chest NN cord-005453-4057qib7 10416 10 X x NN cord-005453-4057qib7 10416 11 - - NN cord-005453-4057qib7 10416 12 ray ray NN cord-005453-4057qib7 10416 13 is be VBZ cord-005453-4057qib7 10416 14 performed perform VBN cord-005453-4057qib7 10416 15 systematically systematically RB cord-005453-4057qib7 10416 16 at at IN cord-005453-4057qib7 10416 17 each each DT cord-005453-4057qib7 10416 18 control control NN cord-005453-4057qib7 10416 19 or or CC cord-005453-4057qib7 10416 20 in in IN cord-005453-4057qib7 10416 21 case case NN cord-005453-4057qib7 10416 22 of of IN cord-005453-4057qib7 10416 23 clinical clinical JJ cord-005453-4057qib7 10416 24 signs sign NNS cord-005453-4057qib7 10416 25 a a DT cord-005453-4057qib7 10416 26 thoracic thoracic JJ cord-005453-4057qib7 10416 27 CT ct NN cord-005453-4057qib7 10416 28 scan scan NN cord-005453-4057qib7 10416 29 is be VBZ cord-005453-4057qib7 10416 30 requested request VBN cord-005453-4057qib7 10416 31 from from IN cord-005453-4057qib7 10416 32 suspicion suspicion NN cord-005453-4057qib7 10416 33 . . . cord-005453-4057qib7 10417 1 The the DT cord-005453-4057qib7 10417 2 diagnosis diagnosis NN cord-005453-4057qib7 10417 3 of of IN cord-005453-4057qib7 10417 4 IPA IPA NNP cord-005453-4057qib7 10417 5 is be VBZ cord-005453-4057qib7 10417 6 made make VBN cord-005453-4057qib7 10417 7 according accord VBG cord-005453-4057qib7 10417 8 to to IN cord-005453-4057qib7 10417 9 the the DT cord-005453-4057qib7 10417 10 criteria criterion NNS cord-005453-4057qib7 10417 11 of of IN cord-005453-4057qib7 10417 12 the the DT cord-005453-4057qib7 10417 13 EORTC EORTC NNP cord-005453-4057qib7 10417 14 - - HYPH cord-005453-4057qib7 10417 15 MSG MSG NNP cord-005453-4057qib7 10417 16 based base VBN cord-005453-4057qib7 10417 17 on on IN cord-005453-4057qib7 10417 18 the the DT cord-005453-4057qib7 10417 19 predisposing predispose VBG cord-005453-4057qib7 10417 20 criteria criterion NNS cord-005453-4057qib7 10417 21 of of IN cord-005453-4057qib7 10417 22 the the DT cord-005453-4057qib7 10417 23 host host NN cord-005453-4057qib7 10417 24 and and CC cord-005453-4057qib7 10417 25 clinico clinico NN cord-005453-4057qib7 10417 26 - - HYPH cord-005453-4057qib7 10417 27 radiological radiological JJ cord-005453-4057qib7 10417 28 criteria criterion NNS cord-005453-4057qib7 10417 29 ( ( -LRB- cord-005453-4057qib7 10417 30 possible possible JJ cord-005453-4057qib7 10417 31 infection infection NN cord-005453-4057qib7 10417 32 ) ) -RRB- cord-005453-4057qib7 10417 33 . . . cord-005453-4057qib7 10418 1 Galactomannan Galactomannan NNP cord-005453-4057qib7 10418 2 antigen antigen NN cord-005453-4057qib7 10418 3 and and CC cord-005453-4057qib7 10418 4 histopathology histopathology NN cord-005453-4057qib7 10418 5 criteria criterion NNS cord-005453-4057qib7 10418 6 are be VBP cord-005453-4057qib7 10418 7 not not RB cord-005453-4057qib7 10418 8 common common JJ cord-005453-4057qib7 10418 9 practice practice NN cord-005453-4057qib7 10418 10 . . . cord-005453-4057qib7 10419 1 Results result NNS cord-005453-4057qib7 10419 2 : : : cord-005453-4057qib7 10420 1 A a DT cord-005453-4057qib7 10420 2 total total NN cord-005453-4057qib7 10420 3 of of IN cord-005453-4057qib7 10420 4 29 29 CD cord-005453-4057qib7 10420 5 IPA IPA NNP cord-005453-4057qib7 10420 6 episodes episode NNS cord-005453-4057qib7 10420 7 ( ( -LRB- cord-005453-4057qib7 10420 8 7 7 CD cord-005453-4057qib7 10420 9 % % NN cord-005453-4057qib7 10420 10 ) ) -RRB- cord-005453-4057qib7 10420 11 were be VBD cord-005453-4057qib7 10420 12 identified identify VBN cord-005453-4057qib7 10420 13 in in IN cord-005453-4057qib7 10420 14 26 26 CD cord-005453-4057qib7 10420 15 pts pt NNS cord-005453-4057qib7 10420 16 ( ( -LRB- cord-005453-4057qib7 10420 17 AML AML NNP cord-005453-4057qib7 10420 18 : : : cord-005453-4057qib7 10420 19 15 15 CD cord-005453-4057qib7 10420 20 , , , cord-005453-4057qib7 10420 21 AA AA NNP cord-005453-4057qib7 10420 22 : : : cord-005453-4057qib7 10420 23 5 5 CD cord-005453-4057qib7 10420 24 , , , cord-005453-4057qib7 10420 25 ALL all DT cord-005453-4057qib7 10420 26 3 3 CD cord-005453-4057qib7 10420 27 , , , cord-005453-4057qib7 10420 28 CML CML NNP cord-005453-4057qib7 10420 29 2 2 CD cord-005453-4057qib7 10420 30 , , , cord-005453-4057qib7 10420 31 MM MM NNP cord-005453-4057qib7 10420 32 1 1 CD cord-005453-4057qib7 10420 33 ) ) -RRB- cord-005453-4057qib7 10420 34 of of IN cord-005453-4057qib7 10420 35 median median JJ cord-005453-4057qib7 10420 36 age age NN cord-005453-4057qib7 10420 37 36 36 CD cord-005453-4057qib7 10420 38 ( ( -LRB- cord-005453-4057qib7 10420 39 8 8 CD cord-005453-4057qib7 10420 40 - - SYM cord-005453-4057qib7 10420 41 56 56 CD cord-005453-4057qib7 10420 42 ) ) -RRB- cord-005453-4057qib7 10420 43 , , , cord-005453-4057qib7 10420 44 sex sex NN cord-005453-4057qib7 10420 45 ratio ratio NN cord-005453-4057qib7 10420 46 : : : cord-005453-4057qib7 10420 47 0.44 0.44 CD cord-005453-4057qib7 10420 48 . . . cord-005453-4057qib7 10421 1 All all DT cord-005453-4057qib7 10421 2 of of IN cord-005453-4057qib7 10421 3 them -PRON- PRP cord-005453-4057qib7 10421 4 had have VBD cord-005453-4057qib7 10421 5 transplantation transplantation NN cord-005453-4057qib7 10421 6 from from IN cord-005453-4057qib7 10421 7 a a DT cord-005453-4057qib7 10421 8 family family NN cord-005453-4057qib7 10421 9 donor donor NN cord-005453-4057qib7 10421 10 ( ( -LRB- cord-005453-4057qib7 10421 11 geno geno NNP cord-005453-4057qib7 10421 12 - - HYPH cord-005453-4057qib7 10421 13 identical identical JJ cord-005453-4057qib7 10421 14 : : : cord-005453-4057qib7 10421 15 22 22 CD cord-005453-4057qib7 10421 16 , , , cord-005453-4057qib7 10421 17 haplo haplo NN cord-005453-4057qib7 10421 18 - - HYPH cord-005453-4057qib7 10421 19 identical identical JJ cord-005453-4057qib7 10421 20 : : : cord-005453-4057qib7 10421 21 4 4 LS cord-005453-4057qib7 10421 22 ) ) -RRB- cord-005453-4057qib7 10421 23 with with IN cord-005453-4057qib7 10421 24 conditioning conditioning NN cord-005453-4057qib7 10421 25 by by IN cord-005453-4057qib7 10421 26 chemotherapy chemotherapy NN cord-005453-4057qib7 10421 27 alone alone RB cord-005453-4057qib7 10421 28 and and CC cord-005453-4057qib7 10421 29 a a DT cord-005453-4057qib7 10421 30 graft graft NN cord-005453-4057qib7 10421 31 of of IN cord-005453-4057qib7 10421 32 CSP CSP NNP cord-005453-4057qib7 10421 33 ( ( -LRB- cord-005453-4057qib7 10421 34 24 24 CD cord-005453-4057qib7 10421 35 pts pt NNS cord-005453-4057qib7 10421 36 ) ) -RRB- cord-005453-4057qib7 10421 37 and and CC cord-005453-4057qib7 10421 38 peripheral peripheral JJ cord-005453-4057qib7 10421 39 stem stem NN cord-005453-4057qib7 10421 40 cells cell NNS cord-005453-4057qib7 10421 41 - - HYPH cord-005453-4057qib7 10421 42 bone bone NN cord-005453-4057qib7 10421 43 marrow marrow NN cord-005453-4057qib7 10421 44 ( ( -LRB- cord-005453-4057qib7 10421 45 2 2 CD cord-005453-4057qib7 10421 46 pts pts CD cord-005453-4057qib7 10421 47 ) ) -RRB- cord-005453-4057qib7 10421 48 . . . cord-005453-4057qib7 10422 1 All all DT cord-005453-4057qib7 10422 2 pts pts NN cord-005453-4057qib7 10422 3 had have VBD cord-005453-4057qib7 10422 4 at at RB cord-005453-4057qib7 10422 5 least least RBS cord-005453-4057qib7 10422 6 one one CD cord-005453-4057qib7 10422 7 predisposing predispose VBG cord-005453-4057qib7 10422 8 risk risk NN cord-005453-4057qib7 10422 9 factor factor NN cord-005453-4057qib7 10422 10 : : : cord-005453-4057qib7 10422 11 antecedent antecedent NN cord-005453-4057qib7 10422 12 of of IN cord-005453-4057qib7 10422 13 aspergillosis aspergillosis NNP cord-005453-4057qib7 10422 14 ( ( -LRB- cord-005453-4057qib7 10422 15 3 3 CD cord-005453-4057qib7 10422 16 pts pts CD cord-005453-4057qib7 10422 17 ) ) -RRB- cord-005453-4057qib7 10422 18 , , , cord-005453-4057qib7 10422 19 prolonged prolong VBN cord-005453-4057qib7 10422 20 neutropenia neutropenia NN cord-005453-4057qib7 10423 1 > > XX cord-005453-4057qib7 10423 2 10 10 CD cord-005453-4057qib7 10423 3 d d NN cord-005453-4057qib7 10423 4 ( ( -LRB- cord-005453-4057qib7 10423 5 5 5 CD cord-005453-4057qib7 10423 6 pts pts CD cord-005453-4057qib7 10423 7 ) ) -RRB- cord-005453-4057qib7 10423 8 , , , cord-005453-4057qib7 10423 9 acute acute JJ cord-005453-4057qib7 10423 10 GVHD GVHD NNP cord-005453-4057qib7 10423 11 ( ( -LRB- cord-005453-4057qib7 10423 12 8 8 CD cord-005453-4057qib7 10423 13 pts pt NNS cord-005453-4057qib7 10423 14 ) ) -RRB- cord-005453-4057qib7 10423 15 , , , cord-005453-4057qib7 10423 16 chronic chronic JJ cord-005453-4057qib7 10423 17 GVHD GVHD NNP cord-005453-4057qib7 10423 18 ( ( -LRB- cord-005453-4057qib7 10423 19 4 4 CD cord-005453-4057qib7 10423 20 pts pts CD cord-005453-4057qib7 10423 21 ) ) -RRB- cord-005453-4057qib7 10423 22 , , , cord-005453-4057qib7 10423 23 prolonged prolong VBN cord-005453-4057qib7 10423 24 corticosteroid corticosteroid NN cord-005453-4057qib7 10423 25 therapy therapy NN cord-005453-4057qib7 10423 26 ≥ ≥ CD cord-005453-4057qib7 10423 27 0,3 0,3 CD cord-005453-4057qib7 10424 1 mg mg NNP cord-005453-4057qib7 10425 1 /kg /kg NFP cord-005453-4057qib7 10425 2 / / SYM cord-005453-4057qib7 10425 3 day day NN cord-005453-4057qib7 10425 4 exceeding exceed VBG cord-005453-4057qib7 10425 5 21 21 CD cord-005453-4057qib7 10425 6 days day NNS cord-005453-4057qib7 10425 7 ( ( -LRB- cord-005453-4057qib7 10425 8 12 12 CD cord-005453-4057qib7 10425 9 pts pt NNS cord-005453-4057qib7 10425 10 ) ) -RRB- cord-005453-4057qib7 10425 11 . . . cord-005453-4057qib7 10426 1 The the DT cord-005453-4057qib7 10426 2 diagnosis diagnosis NN cord-005453-4057qib7 10426 3 of of IN cord-005453-4057qib7 10426 4 API API NNP cord-005453-4057qib7 10426 5 was be VBD cord-005453-4057qib7 10426 6 possible possible JJ cord-005453-4057qib7 10426 7 on on IN cord-005453-4057qib7 10426 8 average average JJ cord-005453-4057qib7 10426 9 at at IN cord-005453-4057qib7 10426 10 J172 J172 NNP cord-005453-4057qib7 10426 11 ( ( -LRB- cord-005453-4057qib7 10426 12 20 20 CD cord-005453-4057qib7 10426 13 - - SYM cord-005453-4057qib7 10426 14 930 930 CD cord-005453-4057qib7 10426 15 ) ) -RRB- cord-005453-4057qib7 10426 16 after after IN cord-005453-4057qib7 10426 17 appearance appearance NN cord-005453-4057qib7 10426 18 of of IN cord-005453-4057qib7 10426 19 clinical clinical JJ cord-005453-4057qib7 10426 20 signs sign NNS cord-005453-4057qib7 10426 21 ( ( -LRB- cord-005453-4057qib7 10426 22 in in IN cord-005453-4057qib7 10426 23 all all DT cord-005453-4057qib7 10426 24 cases case NNS cord-005453-4057qib7 10426 25 ) ) -RRB- cord-005453-4057qib7 10426 26 and and CC cord-005453-4057qib7 10426 27 evocative evocative JJ cord-005453-4057qib7 10426 28 radiological radiological JJ cord-005453-4057qib7 10426 29 in in IN cord-005453-4057qib7 10426 30 25 25 CD cord-005453-4057qib7 10426 31 cases case NNS cord-005453-4057qib7 10426 32 ( ( -LRB- cord-005453-4057qib7 10426 33 in in IN cord-005453-4057qib7 10426 34 4 4 CD cord-005453-4057qib7 10426 35 cases case NNS cord-005453-4057qib7 10426 36 , , , cord-005453-4057qib7 10426 37 the the DT cord-005453-4057qib7 10426 38 standard standard JJ cord-005453-4057qib7 10426 39 chest chest NN cord-005453-4057qib7 10426 40 x x NN cord-005453-4057qib7 10426 41 - - NN cord-005453-4057qib7 10426 42 ray ray NN cord-005453-4057qib7 10426 43 was be VBD cord-005453-4057qib7 10426 44 normal normal JJ cord-005453-4057qib7 10426 45 ) ) -RRB- cord-005453-4057qib7 10426 46 . . . cord-005453-4057qib7 10427 1 At at IN cord-005453-4057qib7 10427 2 the the DT cord-005453-4057qib7 10427 3 time time NN cord-005453-4057qib7 10427 4 of of IN cord-005453-4057qib7 10427 5 thoracic thoracic JJ cord-005453-4057qib7 10427 6 CT CT NNP cord-005453-4057qib7 10427 7 scan scan NN cord-005453-4057qib7 10427 8 , , , cord-005453-4057qib7 10427 9 11 11 CD cord-005453-4057qib7 10427 10 pts pt NNS cord-005453-4057qib7 10427 11 ( ( -LRB- cord-005453-4057qib7 10427 12 37 37 CD cord-005453-4057qib7 10427 13 % % NN cord-005453-4057qib7 10427 14 ) ) -RRB- cord-005453-4057qib7 10427 15 had have VBD cord-005453-4057qib7 10427 16 characteristic characteristic JJ cord-005453-4057qib7 10427 17 signs sign NNS cord-005453-4057qib7 10427 18 : : : cord-005453-4057qib7 10427 19 halo halo NNP cord-005453-4057qib7 10427 20 sign sign NN cord-005453-4057qib7 10427 21 ( ( -LRB- cord-005453-4057qib7 10427 22 6 6 CD cord-005453-4057qib7 10427 23 pts pts CD cord-005453-4057qib7 10427 24 ) ) -RRB- cord-005453-4057qib7 10427 25 , , , cord-005453-4057qib7 10427 26 crescent crescent NN cord-005453-4057qib7 10427 27 sign sign NN cord-005453-4057qib7 10427 28 ( ( -LRB- cord-005453-4057qib7 10427 29 1 1 CD cord-005453-4057qib7 10427 30 pt pt NN cord-005453-4057qib7 10427 31 ) ) -RRB- cord-005453-4057qib7 10427 32 and and CC cord-005453-4057qib7 10427 33 cavity cavity NN cord-005453-4057qib7 10427 34 ( ( -LRB- cord-005453-4057qib7 10427 35 4 4 CD cord-005453-4057qib7 10427 36 pts pts CD cord-005453-4057qib7 10427 37 ) ) -RRB- cord-005453-4057qib7 10427 38 . . . cord-005453-4057qib7 10428 1 Other other JJ cord-005453-4057qib7 10428 2 minor minor JJ cord-005453-4057qib7 10428 3 radiological radiological JJ cord-005453-4057qib7 10428 4 signs sign NNS cord-005453-4057qib7 10428 5 are be VBP cord-005453-4057qib7 10428 6 found find VBN cord-005453-4057qib7 10428 7 in in IN cord-005453-4057qib7 10428 8 the the DT cord-005453-4057qib7 10428 9 other other JJ cord-005453-4057qib7 10428 10 pts pt NNS cord-005453-4057qib7 10428 11 . . . cord-005453-4057qib7 10429 1 Empirical empirical JJ cord-005453-4057qib7 10429 2 first first JJ cord-005453-4057qib7 10429 3 - - HYPH cord-005453-4057qib7 10429 4 line line NN cord-005453-4057qib7 10429 5 antifungal antifungal JJ cord-005453-4057qib7 10429 6 therapy therapy NN cord-005453-4057qib7 10429 7 was be VBD cord-005453-4057qib7 10429 8 started start VBN cord-005453-4057qib7 10429 9 as as IN cord-005453-4057qib7 10429 10 monotherapy monotherapy NN cord-005453-4057qib7 10429 11 in in IN cord-005453-4057qib7 10429 12 14 14 CD cord-005453-4057qib7 10429 13 pts pt NNS cord-005453-4057qib7 10429 14 ( ( -LRB- cord-005453-4057qib7 10429 15 Voriconazole Voriconazole NNP cord-005453-4057qib7 10429 16 : : : cord-005453-4057qib7 10429 17 8 8 CD cord-005453-4057qib7 10429 18 , , , cord-005453-4057qib7 10429 19 Caspofungin Caspofungin NNP cord-005453-4057qib7 10429 20 : : : cord-005453-4057qib7 10429 21 6 6 CD cord-005453-4057qib7 10429 22 pts pts CD cord-005453-4057qib7 10429 23 ) ) -RRB- cord-005453-4057qib7 10429 24 or or CC cord-005453-4057qib7 10429 25 in in IN cord-005453-4057qib7 10429 26 combination combination NN cord-005453-4057qib7 10429 27 in in IN cord-005453-4057qib7 10429 28 12 12 CD cord-005453-4057qib7 10429 29 pts pt NNS cord-005453-4057qib7 10429 30 . . . cord-005453-4057qib7 10430 1 A a DT cord-005453-4057qib7 10430 2 secondline secondline NN cord-005453-4057qib7 10430 3 treatment treatment NN cord-005453-4057qib7 10430 4 was be VBD cord-005453-4057qib7 10430 5 required require VBN cord-005453-4057qib7 10430 6 in in IN cord-005453-4057qib7 10430 7 10 10 CD cord-005453-4057qib7 10430 8 pts pt NNS cord-005453-4057qib7 10430 9 for for IN cord-005453-4057qib7 10430 10 failure failure NN cord-005453-4057qib7 10430 11 after after IN cord-005453-4057qib7 10430 12 an an DT cord-005453-4057qib7 10430 13 average average JJ cord-005453-4057qib7 10430 14 duration duration NN cord-005453-4057qib7 10430 15 of of IN cord-005453-4057qib7 10430 16 7 7 CD cord-005453-4057qib7 10430 17 days day NNS cord-005453-4057qib7 10430 18 . . . cord-005453-4057qib7 10431 1 Three three CD cord-005453-4057qib7 10431 2 pts pt NNS cord-005453-4057qib7 10431 3 presented present VBD cord-005453-4057qib7 10431 4 a a DT cord-005453-4057qib7 10431 5 second second JJ cord-005453-4057qib7 10431 6 episode episode NN cord-005453-4057qib7 10431 7 after after IN cord-005453-4057qib7 10431 8 an an DT cord-005453-4057qib7 10431 9 average average JJ cord-005453-4057qib7 10431 10 delay delay NN cord-005453-4057qib7 10431 11 of of IN cord-005453-4057qib7 10431 12 5 5 CD cord-005453-4057qib7 10431 13 months month NNS cord-005453-4057qib7 10431 14 ( ( -LRB- cord-005453-4057qib7 10431 15 3 3 CD cord-005453-4057qib7 10431 16 ) ) -RRB- cord-005453-4057qib7 10431 17 ( ( -LRB- cord-005453-4057qib7 10431 18 4 4 LS cord-005453-4057qib7 10431 19 ) ) -RRB- cord-005453-4057qib7 10431 20 ( ( -LRB- cord-005453-4057qib7 10431 21 5 5 LS cord-005453-4057qib7 10431 22 ) ) -RRB- cord-005453-4057qib7 10431 23 ( ( -LRB- cord-005453-4057qib7 10431 24 6 6 LS cord-005453-4057qib7 10431 25 ) ) -RRB- cord-005453-4057qib7 10431 26 with with IN cord-005453-4057qib7 10431 27 a a DT cord-005453-4057qib7 10431 28 favorable favorable JJ cord-005453-4057qib7 10431 29 evolution evolution NN cord-005453-4057qib7 10431 30 of of IN cord-005453-4057qib7 10431 31 resumption resumption NN cord-005453-4057qib7 10431 32 of of IN cord-005453-4057qib7 10431 33 thetreatment thetreatment NN cord-005453-4057qib7 10431 34 . . . cord-005453-4057qib7 10432 1 Fourteen fourteen CD cord-005453-4057qib7 10432 2 pts pts NN cord-005453-4057qib7 10432 3 ( ( -LRB- cord-005453-4057qib7 10432 4 54 54 CD cord-005453-4057qib7 10432 5 % % NN cord-005453-4057qib7 10432 6 ) ) -RRB- cord-005453-4057qib7 10432 7 are be VBP cord-005453-4057qib7 10432 8 alive alive JJ cord-005453-4057qib7 10432 9 with with IN cord-005453-4057qib7 10432 10 complete complete JJ cord-005453-4057qib7 10432 11 resolution resolution NN cord-005453-4057qib7 10432 12 after after IN cord-005453-4057qib7 10432 13 a a DT cord-005453-4057qib7 10432 14 median median JJ cord-005453-4057qib7 10432 15 treatment treatment NN cord-005453-4057qib7 10432 16 time time NN cord-005453-4057qib7 10432 17 of of IN cord-005453-4057qib7 10432 18 10 10 CD cord-005453-4057qib7 10432 19 months month NNS cord-005453-4057qib7 10432 20 ( ( -LRB- cord-005453-4057qib7 10432 21 2 2 CD cord-005453-4057qib7 10432 22 - - SYM cord-005453-4057qib7 10432 23 19 19 CD cord-005453-4057qib7 10432 24 ) ) -RRB- cord-005453-4057qib7 10432 25 . . . cord-005453-4057qib7 10433 1 Twelve twelve CD cord-005453-4057qib7 10433 2 pts pt NNS cord-005453-4057qib7 10433 3 ( ( -LRB- cord-005453-4057qib7 10433 4 46 46 CD cord-005453-4057qib7 10433 5 % % NN cord-005453-4057qib7 10433 6 ) ) -RRB- cord-005453-4057qib7 10433 7 died die VBD cord-005453-4057qib7 10433 8 rapidly rapidly RB cord-005453-4057qib7 10433 9 on on IN cord-005453-4057qib7 10433 10 average average JJ cord-005453-4057qib7 10433 11 14 14 CD cord-005453-4057qib7 10433 12 days day NNS cord-005453-4057qib7 10433 13 after after IN cord-005453-4057qib7 10433 14 diagnosis diagnosis NN cord-005453-4057qib7 10433 15 ( ( -LRB- cord-005453-4057qib7 10433 16 IPA IPA NNP cord-005453-4057qib7 10433 17 11 11 CD cord-005453-4057qib7 10433 18 , , , cord-005453-4057qib7 10433 19 relapse relapse NN cord-005453-4057qib7 10433 20 of of IN cord-005453-4057qib7 10433 21 his -PRON- PRP$ cord-005453-4057qib7 10433 22 disease disease NN cord-005453-4057qib7 10433 23 : : : cord-005453-4057qib7 10433 24 1 1 LS cord-005453-4057qib7 10433 25 ) ) -RRB- cord-005453-4057qib7 10433 26 Conclusions conclusion NNS cord-005453-4057qib7 10433 27 : : : cord-005453-4057qib7 10434 1 IPA IPA NNP cord-005453-4057qib7 10434 2 occurring occur VBG cord-005453-4057qib7 10434 3 after after IN cord-005453-4057qib7 10434 4 an an DT cord-005453-4057qib7 10434 5 allograft allograft NN cord-005453-4057qib7 10434 6 of of IN cord-005453-4057qib7 10434 7 allo allo NN cord-005453-4057qib7 10434 8 - - HYPH cord-005453-4057qib7 10434 9 HSCT HSCT NNP cord-005453-4057qib7 10434 10 is be VBZ cord-005453-4057qib7 10434 11 a a DT cord-005453-4057qib7 10434 12 severe severe JJ cord-005453-4057qib7 10434 13 complication complication NN cord-005453-4057qib7 10434 14 with with IN cord-005453-4057qib7 10434 15 high high JJ cord-005453-4057qib7 10434 16 mortality mortality NN cord-005453-4057qib7 10434 17 . . . cord-005453-4057qib7 10435 1 It -PRON- PRP cord-005453-4057qib7 10435 2 is be VBZ cord-005453-4057qib7 10435 3 essential essential JJ cord-005453-4057qib7 10435 4 , , , cord-005453-4057qib7 10435 5 in in IN cord-005453-4057qib7 10435 6 each each DT cord-005453-4057qib7 10435 7 case case NN cord-005453-4057qib7 10435 8 , , , cord-005453-4057qib7 10435 9 to to TO cord-005453-4057qib7 10435 10 identify identify VB cord-005453-4057qib7 10435 11 the the DT cord-005453-4057qib7 10435 12 pts pts NN cord-005453-4057qib7 10435 13 with with IN cord-005453-4057qib7 10435 14 risk risk NN cord-005453-4057qib7 10435 15 factors factor NNS cord-005453-4057qib7 10435 16 , , , cord-005453-4057qib7 10435 17 perform perform VB cord-005453-4057qib7 10435 18 a a DT cord-005453-4057qib7 10435 19 thoracic thoracic JJ cord-005453-4057qib7 10435 20 CT ct NN cord-005453-4057qib7 10435 21 - - NN cord-005453-4057qib7 10435 22 scan scan NN cord-005453-4057qib7 10435 23 , , , cord-005453-4057qib7 10435 24 send send VB cord-005453-4057qib7 10435 25 serum serum NN cord-005453-4057qib7 10435 26 serology serology NN cord-005453-4057qib7 10435 27 for for IN cord-005453-4057qib7 10435 28 apergillus apergillus NNP cord-005453-4057qib7 10436 1 galactomannan galactomannan NNP cord-005453-4057qib7 10436 2 antigenand antigenand NNP cord-005453-4057qib7 10436 3 start start VB cord-005453-4057qib7 10436 4 specific specific JJ cord-005453-4057qib7 10436 5 treatment treatment NN cord-005453-4057qib7 10436 6 as as RB cord-005453-4057qib7 10436 7 soon soon RB cord-005453-4057qib7 10436 8 as as IN cord-005453-4057qib7 10436 9 possible possible JJ cord-005453-4057qib7 10436 10 while while IN cord-005453-4057qib7 10436 11 waiting wait VBG cord-005453-4057qib7 10436 12 to to TO cord-005453-4057qib7 10436 13 be be VB cord-005453-4057qib7 10436 14 able able JJ cord-005453-4057qib7 10436 15 to to TO cord-005453-4057qib7 10436 16 reinforce reinforce VB cord-005453-4057qib7 10436 17 the the DT cord-005453-4057qib7 10436 18 diagnosis diagnosis NN cord-005453-4057qib7 10436 19 by by IN cord-005453-4057qib7 10436 20 direct direct JJ cord-005453-4057qib7 10436 21 examination examination NN cord-005453-4057qib7 10436 22 or or CC cord-005453-4057qib7 10436 23 sputum sputum NN cord-005453-4057qib7 10436 24 or or CC cord-005453-4057qib7 10436 25 brochoalveolar brochoalveolar JJ cord-005453-4057qib7 10436 26 lavage lavage NN cord-005453-4057qib7 10436 27 with with IN cord-005453-4057qib7 10436 28 aspiration aspiration NN cord-005453-4057qib7 10436 29 . . . cord-005453-4057qib7 10437 1 Disclosure disclosure NN cord-005453-4057qib7 10437 2 : : : cord-005453-4057qib7 10437 3 Nothing nothing NN cord-005453-4057qib7 10437 4 to to TO cord-005453-4057qib7 10437 5 declare declare VB cord-005453-4057qib7 10437 6 Background background NN cord-005453-4057qib7 10437 7 : : : cord-005453-4057qib7 10437 8 CMV CMV NNP cord-005453-4057qib7 10437 9 ( ( -LRB- cord-005453-4057qib7 10437 10 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 10437 11 ) ) -RRB- cord-005453-4057qib7 10437 12 has have VBZ cord-005453-4057qib7 10437 13 a a DT cord-005453-4057qib7 10437 14 prevalence prevalence NN cord-005453-4057qib7 10437 15 varying vary VBG cord-005453-4057qib7 10437 16 between between IN cord-005453-4057qib7 10437 17 45 45 CD cord-005453-4057qib7 10437 18 - - SYM cord-005453-4057qib7 10437 19 100 100 CD cord-005453-4057qib7 10437 20 % % NN cord-005453-4057qib7 10437 21 . . . cord-005453-4057qib7 10438 1 Its -PRON- PRP$ cord-005453-4057qib7 10438 2 pathogenicity pathogenicity NN cord-005453-4057qib7 10438 3 is be VBZ cord-005453-4057qib7 10438 4 relatively relatively RB cord-005453-4057qib7 10438 5 low low JJ cord-005453-4057qib7 10438 6 in in IN cord-005453-4057qib7 10438 7 the the DT cord-005453-4057qib7 10438 8 general general JJ cord-005453-4057qib7 10438 9 population population NN cord-005453-4057qib7 10438 10 , , , cord-005453-4057qib7 10438 11 usually usually RB cord-005453-4057qib7 10438 12 resulting result VBG cord-005453-4057qib7 10438 13 in in IN cord-005453-4057qib7 10438 14 a a DT cord-005453-4057qib7 10438 15 selflimiting selflimite VBG cord-005453-4057qib7 10438 16 viral viral JJ cord-005453-4057qib7 10438 17 illness illness NN cord-005453-4057qib7 10438 18 . . . cord-005453-4057qib7 10439 1 In in IN cord-005453-4057qib7 10439 2 an an DT cord-005453-4057qib7 10439 3 immunosuppressed immunosuppressed JJ cord-005453-4057qib7 10439 4 host host NN cord-005453-4057qib7 10439 5 , , , cord-005453-4057qib7 10439 6 infection infection NN cord-005453-4057qib7 10439 7 can can MD cord-005453-4057qib7 10439 8 lead lead VB cord-005453-4057qib7 10439 9 to to IN cord-005453-4057qib7 10439 10 life life NN cord-005453-4057qib7 10439 11 threatening threaten VBG cord-005453-4057qib7 10439 12 illness illness NN cord-005453-4057qib7 10439 13 . . . cord-005453-4057qib7 10440 1 Disseminated disseminate VBN cord-005453-4057qib7 10440 2 CMV CMV NNP cord-005453-4057qib7 10440 3 infection infection NN cord-005453-4057qib7 10440 4 can can MD cord-005453-4057qib7 10440 5 manifest manifest VB cord-005453-4057qib7 10440 6 in in IN cord-005453-4057qib7 10440 7 a a DT cord-005453-4057qib7 10440 8 number number NN cord-005453-4057qib7 10440 9 of of IN cord-005453-4057qib7 10440 10 organs organ NNS cord-005453-4057qib7 10440 11 and and CC cord-005453-4057qib7 10440 12 is be VBZ cord-005453-4057qib7 10440 13 diagnosed diagnose VBN cord-005453-4057qib7 10440 14 using use VBG cord-005453-4057qib7 10440 15 internationally internationally RB cord-005453-4057qib7 10440 16 accepted accept VBN cord-005453-4057qib7 10440 17 criteria criterion NNS cord-005453-4057qib7 10440 18 . . . cord-005453-4057qib7 10441 1 In in IN cord-005453-4057qib7 10441 2 the the DT cord-005453-4057qib7 10441 3 post post JJ cord-005453-4057qib7 10441 4 solid solid JJ cord-005453-4057qib7 10441 5 organ organ NN cord-005453-4057qib7 10441 6 and and CC cord-005453-4057qib7 10441 7 stem stem NN cord-005453-4057qib7 10441 8 cell cell NN cord-005453-4057qib7 10441 9 transplant transplant NN cord-005453-4057qib7 10441 10 ( ( -LRB- cord-005453-4057qib7 10441 11 SCT SCT NNP cord-005453-4057qib7 10441 12 ) ) -RRB- cord-005453-4057qib7 10441 13 setting setting NN cord-005453-4057qib7 10441 14 , , , cord-005453-4057qib7 10441 15 it -PRON- PRP cord-005453-4057qib7 10441 16 is be VBZ cord-005453-4057qib7 10441 17 postulated postulate VBN cord-005453-4057qib7 10441 18 that that IN cord-005453-4057qib7 10441 19 it -PRON- PRP cord-005453-4057qib7 10441 20 is be VBZ cord-005453-4057qib7 10441 21 viral viral JJ cord-005453-4057qib7 10441 22 reactivation reactivation NN cord-005453-4057qib7 10441 23 , , , cord-005453-4057qib7 10441 24 rather rather RB cord-005453-4057qib7 10441 25 than than IN cord-005453-4057qib7 10441 26 primary primary JJ cord-005453-4057qib7 10441 27 reinfection reinfection NN cord-005453-4057qib7 10441 28 that that WDT cord-005453-4057qib7 10441 29 leads lead VBZ cord-005453-4057qib7 10441 30 to to IN cord-005453-4057qib7 10441 31 CMV CMV NNP cord-005453-4057qib7 10441 32 viraemia viraemia NN cord-005453-4057qib7 10441 33 . . . cord-005453-4057qib7 10442 1 Prevention prevention NN cord-005453-4057qib7 10442 2 of of IN cord-005453-4057qib7 10442 3 reactivation reactivation NN cord-005453-4057qib7 10442 4 requires require VBZ cord-005453-4057qib7 10442 5 the the DT cord-005453-4057qib7 10442 6 presence presence NN cord-005453-4057qib7 10442 7 of of IN cord-005453-4057qib7 10442 8 a a DT cord-005453-4057qib7 10442 9 competent competent JJ cord-005453-4057qib7 10442 10 immune immune JJ cord-005453-4057qib7 10442 11 system system NN cord-005453-4057qib7 10442 12 , , , cord-005453-4057qib7 10442 13 mediated mediate VBN cord-005453-4057qib7 10442 14 by by IN cord-005453-4057qib7 10442 15 T T NNP cord-005453-4057qib7 10442 16 - - HYPH cord-005453-4057qib7 10442 17 cells cell NNS cord-005453-4057qib7 10442 18 . . . cord-005453-4057qib7 10443 1 This this DT cord-005453-4057qib7 10443 2 accounts account VBZ cord-005453-4057qib7 10443 3 for for IN cord-005453-4057qib7 10443 4 the the DT cord-005453-4057qib7 10443 5 increased increase VBN cord-005453-4057qib7 10443 6 incidence incidence NN cord-005453-4057qib7 10443 7 in in IN cord-005453-4057qib7 10443 8 intensive intensive JJ cord-005453-4057qib7 10443 9 and and CC cord-005453-4057qib7 10443 10 T t NN cord-005453-4057qib7 10443 11 - - HYPH cord-005453-4057qib7 10443 12 cell cell NN cord-005453-4057qib7 10443 13 depleting deplete VBG cord-005453-4057qib7 10443 14 SCT SCT NNP cord-005453-4057qib7 10443 15 conditioning conditioning NN cord-005453-4057qib7 10443 16 regimens regimen NNS cord-005453-4057qib7 10443 17 . . . cord-005453-4057qib7 10444 1 Despite despite IN cord-005453-4057qib7 10444 2 improved improved JJ cord-005453-4057qib7 10444 3 outcomes outcome NNS cord-005453-4057qib7 10444 4 following follow VBG cord-005453-4057qib7 10444 5 the the DT cord-005453-4057qib7 10444 6 introduction introduction NN cord-005453-4057qib7 10444 7 of of IN cord-005453-4057qib7 10444 8 CMV CMV NNP cord-005453-4057qib7 10444 9 monitoring monitoring NN cord-005453-4057qib7 10444 10 by by IN cord-005453-4057qib7 10444 11 PCR PCR NNP cord-005453-4057qib7 10444 12 and and CC cord-005453-4057qib7 10444 13 pre pre JJ cord-005453-4057qib7 10444 14 - - JJ cord-005453-4057qib7 10444 15 emptive emptive JJ cord-005453-4057qib7 10444 16 treatments treatment NNS cord-005453-4057qib7 10444 17 ( ( -LRB- cord-005453-4057qib7 10444 18 current current JJ cord-005453-4057qib7 10444 19 UK UK NNP cord-005453-4057qib7 10444 20 guidance guidance NN cord-005453-4057qib7 10444 21 ) ) -RRB- cord-005453-4057qib7 10444 22 , , , cord-005453-4057qib7 10444 23 CMV CMV NNP cord-005453-4057qib7 10444 24 pneumonitis pneumonitis NN cord-005453-4057qib7 10444 25 still still RB cord-005453-4057qib7 10444 26 carries carry VBZ cord-005453-4057qib7 10444 27 a a DT cord-005453-4057qib7 10444 28 high high JJ cord-005453-4057qib7 10444 29 mortality mortality NN cord-005453-4057qib7 10444 30 . . . cord-005453-4057qib7 10445 1 The the DT cord-005453-4057qib7 10445 2 use use NN cord-005453-4057qib7 10445 3 of of IN cord-005453-4057qib7 10445 4 CMV CMV NNP cord-005453-4057qib7 10445 5 specific specific JJ cord-005453-4057qib7 10445 6 immunoglobulins immunoglobulin NNS cord-005453-4057qib7 10445 7 ( ( -LRB- cord-005453-4057qib7 10445 8 CMVIG CMVIG NNP cord-005453-4057qib7 10445 9 ) ) -RRB- cord-005453-4057qib7 10445 10 for for IN cord-005453-4057qib7 10445 11 the the DT cord-005453-4057qib7 10445 12 treatment treatment NN cord-005453-4057qib7 10445 13 of of IN cord-005453-4057qib7 10445 14 this this DT cord-005453-4057qib7 10445 15 complication complication NN cord-005453-4057qib7 10445 16 is be VBZ cord-005453-4057qib7 10445 17 generally generally RB cord-005453-4057qib7 10445 18 not not RB cord-005453-4057qib7 10445 19 recommended recommend VBN cord-005453-4057qib7 10445 20 post post NN cord-005453-4057qib7 10445 21 chemotherapy chemotherapy NN cord-005453-4057qib7 10445 22 or or CC cord-005453-4057qib7 10445 23 SCT SCT NNP cord-005453-4057qib7 10445 24 in in IN cord-005453-4057qib7 10445 25 haematological haematological JJ cord-005453-4057qib7 10445 26 cancers cancer NNS cord-005453-4057qib7 10445 27 due due JJ cord-005453-4057qib7 10445 28 to to IN cord-005453-4057qib7 10445 29 lack lack NN cord-005453-4057qib7 10445 30 of of IN cord-005453-4057qib7 10445 31 evidence evidence NN cord-005453-4057qib7 10445 32 . . . cord-005453-4057qib7 10446 1 However however RB cord-005453-4057qib7 10446 2 , , , cord-005453-4057qib7 10446 3 CMVIGs cmvig NNS cord-005453-4057qib7 10446 4 are be VBP cord-005453-4057qib7 10446 5 widely widely RB cord-005453-4057qib7 10446 6 used use VBN cord-005453-4057qib7 10446 7 in in IN cord-005453-4057qib7 10446 8 the the DT cord-005453-4057qib7 10446 9 setting setting NN cord-005453-4057qib7 10446 10 of of IN cord-005453-4057qib7 10446 11 CMV CMV NNP cord-005453-4057qib7 10446 12 reactivation reactivation NN cord-005453-4057qib7 10446 13 post post VBP cord-005453-4057qib7 10446 14 solid solid JJ cord-005453-4057qib7 10446 15 organ organ NN cord-005453-4057qib7 10446 16 transplants transplant NNS cord-005453-4057qib7 10446 17 . . . cord-005453-4057qib7 10447 1 We -PRON- PRP cord-005453-4057qib7 10447 2 report report VBP cord-005453-4057qib7 10447 3 the the DT cord-005453-4057qib7 10447 4 use use NN cord-005453-4057qib7 10447 5 of of IN cord-005453-4057qib7 10447 6 CMVIG CMVIG NNP cord-005453-4057qib7 10447 7 in in IN cord-005453-4057qib7 10447 8 patients patient NNS cord-005453-4057qib7 10447 9 with with IN cord-005453-4057qib7 10447 10 suspected suspect VBN cord-005453-4057qib7 10447 11 CMV CMV NNP cord-005453-4057qib7 10447 12 pneumonitis pneumonitis NN cord-005453-4057qib7 10447 13 at at IN cord-005453-4057qib7 10447 14 a a DT cord-005453-4057qib7 10447 15 single single JJ cord-005453-4057qib7 10447 16 UK UK NNP cord-005453-4057qib7 10447 17 centre centre NN cord-005453-4057qib7 10447 18 . . . cord-005453-4057qib7 10448 1 The the DT cord-005453-4057qib7 10448 2 aims aim NNS cord-005453-4057qib7 10448 3 of of IN cord-005453-4057qib7 10448 4 this this DT cord-005453-4057qib7 10448 5 retrospective retrospective JJ cord-005453-4057qib7 10448 6 study study NN cord-005453-4057qib7 10448 7 were be VBD cord-005453-4057qib7 10448 8 to to TO cord-005453-4057qib7 10448 9 establish establish VB cord-005453-4057qib7 10448 10 safety safety NN cord-005453-4057qib7 10448 11 and and CC cord-005453-4057qib7 10448 12 review review VB cord-005453-4057qib7 10448 13 efficacy efficacy NN cord-005453-4057qib7 10448 14 in in IN cord-005453-4057qib7 10448 15 this this DT cord-005453-4057qib7 10448 16 highly highly RB cord-005453-4057qib7 10448 17 immunocompromised immunocompromised JJ cord-005453-4057qib7 10448 18 group group NN cord-005453-4057qib7 10448 19 of of IN cord-005453-4057qib7 10448 20 patients patient NNS cord-005453-4057qib7 10448 21 . . . cord-005453-4057qib7 10449 1 Methods method NNS cord-005453-4057qib7 10449 2 : : : cord-005453-4057qib7 10450 1 Data datum NNS cord-005453-4057qib7 10450 2 was be VBD cord-005453-4057qib7 10450 3 collected collect VBN cord-005453-4057qib7 10450 4 retrospectively retrospectively RB cord-005453-4057qib7 10450 5 on on IN cord-005453-4057qib7 10450 6 the the DT cord-005453-4057qib7 10450 7 use use NN cord-005453-4057qib7 10450 8 of of IN cord-005453-4057qib7 10450 9 CMVIG CMVIG NNP cord-005453-4057qib7 10450 10 in in IN cord-005453-4057qib7 10450 11 patients patient NNS cord-005453-4057qib7 10450 12 with with IN cord-005453-4057qib7 10450 13 haematological haematological JJ cord-005453-4057qib7 10450 14 cancers cancer NNS cord-005453-4057qib7 10450 15 post post NN cord-005453-4057qib7 10450 16 SCT SCT NNP cord-005453-4057qib7 10450 17 or or CC cord-005453-4057qib7 10450 18 chemotherapy chemotherapy NN cord-005453-4057qib7 10450 19 alone alone RB cord-005453-4057qib7 10450 20 between between IN cord-005453-4057qib7 10450 21 2007 2007 CD cord-005453-4057qib7 10450 22 and and CC cord-005453-4057qib7 10450 23 2017 2017 CD cord-005453-4057qib7 10450 24 at at IN cord-005453-4057qib7 10450 25 Manchester Manchester NNP cord-005453-4057qib7 10450 26 Royal Royal NNP cord-005453-4057qib7 10450 27 Infirmary Infirmary NNP cord-005453-4057qib7 10450 28 , , , cord-005453-4057qib7 10450 29 UK UK NNP cord-005453-4057qib7 10450 30 . . . cord-005453-4057qib7 10451 1 All all DT cord-005453-4057qib7 10451 2 patients patient NNS cord-005453-4057qib7 10451 3 included include VBD cord-005453-4057qib7 10451 4 had have VBD cord-005453-4057qib7 10451 5 CMV CMV NNP cord-005453-4057qib7 10451 6 positive positive JJ cord-005453-4057qib7 10451 7 PCR pcr NN cord-005453-4057qib7 10451 8 in in IN cord-005453-4057qib7 10451 9 blood blood NN cord-005453-4057qib7 10451 10 ( ( -LRB- cord-005453-4057qib7 10451 11 and and CC cord-005453-4057qib7 10451 12 or or CC cord-005453-4057qib7 10451 13 from from IN cord-005453-4057qib7 10451 14 bronchoscopy bronchoscopy NN cord-005453-4057qib7 10451 15 ) ) -RRB- cord-005453-4057qib7 10451 16 , , , cord-005453-4057qib7 10451 17 as as RB cord-005453-4057qib7 10451 18 well well RB cord-005453-4057qib7 10451 19 as as IN cord-005453-4057qib7 10451 20 high high JJ cord-005453-4057qib7 10451 21 resolution resolution NN cord-005453-4057qib7 10451 22 CT CT NNP cord-005453-4057qib7 10451 23 imaging image VBG cord-005453-4057qib7 10451 24 evidence evidence NN cord-005453-4057qib7 10451 25 of of IN cord-005453-4057qib7 10451 26 CMV CMV NNP cord-005453-4057qib7 10451 27 infection infection NN cord-005453-4057qib7 10451 28 . . . cord-005453-4057qib7 10452 1 The the DT cord-005453-4057qib7 10452 2 data datum NNS cord-005453-4057qib7 10452 3 was be VBD cord-005453-4057qib7 10452 4 sourced source VBN cord-005453-4057qib7 10452 5 from from IN cord-005453-4057qib7 10452 6 pharmacy pharmacy NN cord-005453-4057qib7 10452 7 database database NN cord-005453-4057qib7 10452 8 and and CC cord-005453-4057qib7 10452 9 crossreferenced crossreference VBN cord-005453-4057qib7 10452 10 with with IN cord-005453-4057qib7 10452 11 a a DT cord-005453-4057qib7 10452 12 departmental departmental JJ cord-005453-4057qib7 10452 13 list list NN cord-005453-4057qib7 10452 14 . . . cord-005453-4057qib7 10453 1 For for IN cord-005453-4057qib7 10453 2 each each DT cord-005453-4057qib7 10453 3 patient patient NN cord-005453-4057qib7 10453 4 identified identify VBN cord-005453-4057qib7 10453 5 , , , cord-005453-4057qib7 10453 6 case case NN cord-005453-4057qib7 10453 7 notes note NNS cord-005453-4057qib7 10453 8 and and CC cord-005453-4057qib7 10453 9 prescriptions prescription NNS cord-005453-4057qib7 10453 10 were be VBD cord-005453-4057qib7 10453 11 sourced source VBN cord-005453-4057qib7 10453 12 . . . cord-005453-4057qib7 10454 1 Data datum NNS cord-005453-4057qib7 10454 2 collected collect VBD cord-005453-4057qib7 10454 3 included include VBN cord-005453-4057qib7 10454 4 patient patient JJ cord-005453-4057qib7 10454 5 baseline baseline JJ cord-005453-4057qib7 10454 6 characteristics characteristic NNS cord-005453-4057qib7 10454 7 , , , cord-005453-4057qib7 10454 8 timing timing NN cord-005453-4057qib7 10454 9 of of IN cord-005453-4057qib7 10454 10 treatment treatment NN cord-005453-4057qib7 10454 11 , , , cord-005453-4057qib7 10454 12 number number NN cord-005453-4057qib7 10454 13 of of IN cord-005453-4057qib7 10454 14 doses dose NNS cord-005453-4057qib7 10454 15 of of IN cord-005453-4057qib7 10454 16 CMVIG CMVIG NNP cord-005453-4057qib7 10454 17 and and CC cord-005453-4057qib7 10454 18 outcome outcome NN cord-005453-4057qib7 10454 19 . . . cord-005453-4057qib7 10455 1 Results result NNS cord-005453-4057qib7 10455 2 : : : cord-005453-4057qib7 10456 1 Eight eight CD cord-005453-4057qib7 10456 2 patients patient NNS cord-005453-4057qib7 10456 3 received receive VBD cord-005453-4057qib7 10456 4 CMVIG CMVIG NNP cord-005453-4057qib7 10456 5 for for IN cord-005453-4057qib7 10456 6 suspected suspect VBN cord-005453-4057qib7 10456 7 CMV CMV NNP cord-005453-4057qib7 10456 8 pneumonitis pneumonitis NN cord-005453-4057qib7 10456 9 . . . cord-005453-4057qib7 10457 1 Seven seven CD cord-005453-4057qib7 10457 2 patients patient NNS cord-005453-4057qib7 10457 3 were be VBD cord-005453-4057qib7 10457 4 post post JJ cord-005453-4057qib7 10457 5 SCT SCT NNP cord-005453-4057qib7 10457 6 and and CC cord-005453-4057qib7 10457 7 one one CD cord-005453-4057qib7 10457 8 patient patient NN cord-005453-4057qib7 10457 9 was be VBD cord-005453-4057qib7 10457 10 severely severely RB cord-005453-4057qib7 10457 11 immunosuppressed immunosuppressed JJ cord-005453-4057qib7 10457 12 with with IN cord-005453-4057qib7 10457 13 chemotherapy chemotherapy NN cord-005453-4057qib7 10457 14 alone alone JJ cord-005453-4057qib7 10457 15 . . . cord-005453-4057qib7 10458 1 Median median JJ cord-005453-4057qib7 10458 2 age age NN cord-005453-4057qib7 10458 3 was be VBD cord-005453-4057qib7 10458 4 40 40 CD cord-005453-4057qib7 10458 5 years year NNS cord-005453-4057qib7 10459 1 ( ( -LRB- cord-005453-4057qib7 10459 2 range range NNP cord-005453-4057qib7 10459 3 16 16 CD cord-005453-4057qib7 10459 4 - - SYM cord-005453-4057qib7 10459 5 68 68 CD cord-005453-4057qib7 10459 6 ) ) -RRB- cord-005453-4057qib7 10459 7 . . . cord-005453-4057qib7 10460 1 The the DT cord-005453-4057qib7 10460 2 CMVIG CMVIG NNP cord-005453-4057qib7 10460 3 regimen regimen NN cord-005453-4057qib7 10460 4 used use VBD cord-005453-4057qib7 10460 5 was be VBD cord-005453-4057qib7 10460 6 4ml 4ml JJ cord-005453-4057qib7 10460 7 / / SYM cord-005453-4057qib7 10460 8 kg kg NNS cord-005453-4057qib7 10460 9 of of IN cord-005453-4057qib7 10460 10 Cytotect Cytotect NNP cord-005453-4057qib7 10461 1 ® ® VBN cord-005453-4057qib7 10461 2 on on IN cord-005453-4057qib7 10461 3 days day NNS cord-005453-4057qib7 10461 4 0 0 CD cord-005453-4057qib7 10461 5 , , , cord-005453-4057qib7 10461 6 2 2 CD cord-005453-4057qib7 10461 7 , , , cord-005453-4057qib7 10461 8 4 4 CD cord-005453-4057qib7 10461 9 and and CC cord-005453-4057qib7 10461 10 6 6 CD cord-005453-4057qib7 10461 11 , , , cord-005453-4057qib7 10461 12 followed follow VBN cord-005453-4057qib7 10461 13 by by IN cord-005453-4057qib7 10461 14 2ml 2ml NNP cord-005453-4057qib7 10461 15 / / SYM cord-005453-4057qib7 10461 16 kg kg NN cord-005453-4057qib7 10461 17 every every DT cord-005453-4057qib7 10461 18 four four CD cord-005453-4057qib7 10461 19 days day NNS cord-005453-4057qib7 10461 20 until until IN cord-005453-4057qib7 10461 21 resolution resolution NN cord-005453-4057qib7 10461 22 of of IN cord-005453-4057qib7 10461 23 symptoms symptom NNS cord-005453-4057qib7 10461 24 . . . cord-005453-4057qib7 10462 1 There there EX cord-005453-4057qib7 10462 2 were be VBD cord-005453-4057qib7 10462 3 no no DT cord-005453-4057qib7 10462 4 infusion infusion NN cord-005453-4057qib7 10462 5 related relate VBN cord-005453-4057qib7 10462 6 reactions reaction NNS cord-005453-4057qib7 10462 7 observed observe VBD cord-005453-4057qib7 10462 8 . . . cord-005453-4057qib7 10463 1 Patients patient NNS cord-005453-4057qib7 10463 2 received receive VBD cord-005453-4057qib7 10463 3 a a DT cord-005453-4057qib7 10463 4 median median NN cord-005453-4057qib7 10463 5 of of IN cord-005453-4057qib7 10463 6 4 4 CD cord-005453-4057qib7 10463 7 doses dose NNS cord-005453-4057qib7 10463 8 of of IN cord-005453-4057qib7 10463 9 CMVIG CMVIG NNP cord-005453-4057qib7 10463 10 . . . cord-005453-4057qib7 10464 1 Four four CD cord-005453-4057qib7 10464 2 out out IN cord-005453-4057qib7 10464 3 of of IN cord-005453-4057qib7 10464 4 8 8 CD cord-005453-4057qib7 10464 5 patients patient NNS cord-005453-4057qib7 10464 6 responded respond VBD cord-005453-4057qib7 10464 7 to to IN cord-005453-4057qib7 10464 8 the the DT cord-005453-4057qib7 10464 9 treatment treatment NN cord-005453-4057qib7 10464 10 and and CC cord-005453-4057qib7 10464 11 showed show VBD cord-005453-4057qib7 10464 12 full full JJ cord-005453-4057qib7 10464 13 recovery recovery NN cord-005453-4057qib7 10464 14 but but CC cord-005453-4057qib7 10464 15 only only RB cord-005453-4057qib7 10464 16 3 3 CD cord-005453-4057qib7 10464 17 are be VBP cord-005453-4057qib7 10464 18 alive alive JJ cord-005453-4057qib7 10464 19 and and CC cord-005453-4057qib7 10464 20 well well RB cord-005453-4057qib7 10464 21 to to IN cord-005453-4057qib7 10464 22 date date NN cord-005453-4057qib7 10464 23 . . . cord-005453-4057qib7 10465 1 Conclusions conclusion NNS cord-005453-4057qib7 10465 2 : : : cord-005453-4057qib7 10466 1 This this DT cord-005453-4057qib7 10466 2 study study NN cord-005453-4057qib7 10466 3 shows show VBZ cord-005453-4057qib7 10466 4 that that IN cord-005453-4057qib7 10466 5 the the DT cord-005453-4057qib7 10466 6 use use NN cord-005453-4057qib7 10466 7 of of IN cord-005453-4057qib7 10466 8 CMVIG CMVIG NNP cord-005453-4057qib7 10466 9 is be VBZ cord-005453-4057qib7 10466 10 safe safe JJ cord-005453-4057qib7 10466 11 in in IN cord-005453-4057qib7 10466 12 the the DT cord-005453-4057qib7 10466 13 post post JJ cord-005453-4057qib7 10466 14 - - JJ cord-005453-4057qib7 10466 15 SCT sct JJ cord-005453-4057qib7 10466 16 setting setting NN cord-005453-4057qib7 10466 17 of of IN cord-005453-4057qib7 10466 18 acutely acutely RB cord-005453-4057qib7 10466 19 unwell unwell JJ cord-005453-4057qib7 10466 20 patients patient NNS cord-005453-4057qib7 10466 21 with with IN cord-005453-4057qib7 10466 22 multi multi JJ cord-005453-4057qib7 10466 23 - - JJ cord-005453-4057qib7 10466 24 organ organ JJ cord-005453-4057qib7 10466 25 failure failure NN cord-005453-4057qib7 10466 26 . . . cord-005453-4057qib7 10467 1 Despite despite IN cord-005453-4057qib7 10467 2 limitations limitation NNS cord-005453-4057qib7 10467 3 of of IN cord-005453-4057qib7 10467 4 retrospective retrospective JJ cord-005453-4057qib7 10467 5 studies study NNS cord-005453-4057qib7 10467 6 , , , cord-005453-4057qib7 10467 7 there there EX cord-005453-4057qib7 10467 8 appears appear VBZ cord-005453-4057qib7 10467 9 to to TO cord-005453-4057qib7 10467 10 be be VB cord-005453-4057qib7 10467 11 benefit benefit NN cord-005453-4057qib7 10467 12 for for IN cord-005453-4057qib7 10467 13 the the DT cord-005453-4057qib7 10467 14 use use NN cord-005453-4057qib7 10467 15 of of IN cord-005453-4057qib7 10467 16 CMVIG CMVIG NNP cord-005453-4057qib7 10467 17 in in IN cord-005453-4057qib7 10467 18 our -PRON- PRP$ cord-005453-4057qib7 10467 19 patient patient JJ cord-005453-4057qib7 10467 20 population population NN cord-005453-4057qib7 10467 21 , , , cord-005453-4057qib7 10467 22 with with IN cord-005453-4057qib7 10467 23 50 50 CD cord-005453-4057qib7 10467 24 % % NN cord-005453-4057qib7 10467 25 of of IN cord-005453-4057qib7 10467 26 patients patient NNS cord-005453-4057qib7 10467 27 showing show VBG cord-005453-4057qib7 10467 28 a a DT cord-005453-4057qib7 10467 29 full full JJ cord-005453-4057qib7 10467 30 recovery recovery NN cord-005453-4057qib7 10467 31 from from IN cord-005453-4057qib7 10467 32 that that DT cord-005453-4057qib7 10467 33 episode episode NN cord-005453-4057qib7 10467 34 . . . cord-005453-4057qib7 10468 1 Allogeneic Allogeneic NNP cord-005453-4057qib7 10468 2 SCT SCT NNP cord-005453-4057qib7 10468 3 plays play VBZ cord-005453-4057qib7 10468 4 a a DT cord-005453-4057qib7 10468 5 confounding confounding JJ cord-005453-4057qib7 10468 6 role role NN cord-005453-4057qib7 10468 7 in in IN cord-005453-4057qib7 10468 8 the the DT cord-005453-4057qib7 10468 9 outcome outcome NN cord-005453-4057qib7 10468 10 of of IN cord-005453-4057qib7 10468 11 patients patient NNS cord-005453-4057qib7 10468 12 although although IN cord-005453-4057qib7 10468 13 the the DT cord-005453-4057qib7 10468 14 numbers number NNS cord-005453-4057qib7 10468 15 in in IN cord-005453-4057qib7 10468 16 our -PRON- PRP$ cord-005453-4057qib7 10468 17 study study NN cord-005453-4057qib7 10468 18 are be VBP cord-005453-4057qib7 10468 19 small small JJ cord-005453-4057qib7 10468 20 . . . cord-005453-4057qib7 10469 1 There there EX cord-005453-4057qib7 10469 2 is be VBZ cord-005453-4057qib7 10469 3 clearly clearly RB cord-005453-4057qib7 10469 4 a a DT cord-005453-4057qib7 10469 5 need need NN cord-005453-4057qib7 10469 6 for for IN cord-005453-4057qib7 10469 7 better well JJR cord-005453-4057qib7 10469 8 treatments treatment NNS cord-005453-4057qib7 10469 9 of of IN cord-005453-4057qib7 10469 10 CMV CMV NNP cord-005453-4057qib7 10469 11 pneumonitis pneumonitis NN cord-005453-4057qib7 10469 12 . . . cord-005453-4057qib7 10470 1 CMVIG CMVIG NNP cord-005453-4057qib7 10470 2 is be VBZ cord-005453-4057qib7 10470 3 a a DT cord-005453-4057qib7 10470 4 promising promising JJ cord-005453-4057qib7 10470 5 treatment treatment NN cord-005453-4057qib7 10470 6 but but CC cord-005453-4057qib7 10470 7 further further JJ cord-005453-4057qib7 10470 8 studies study NNS cord-005453-4057qib7 10470 9 are be VBP cord-005453-4057qib7 10470 10 needed need VBN cord-005453-4057qib7 10470 11 to to TO cord-005453-4057qib7 10470 12 identify identify VB cord-005453-4057qib7 10470 13 the the DT cord-005453-4057qib7 10470 14 optimal optimal JJ cord-005453-4057qib7 10470 15 dosing dose VBG cord-005453-4057qib7 10470 16 regimen regimen NN cord-005453-4057qib7 10470 17 and and CC cord-005453-4057qib7 10470 18 provide provide VB cord-005453-4057qib7 10470 19 evidence evidence NN cord-005453-4057qib7 10470 20 of of IN cord-005453-4057qib7 10470 21 efficacy efficacy NN cord-005453-4057qib7 10470 22 . . . cord-005453-4057qib7 10471 1 Disclosure disclosure NN cord-005453-4057qib7 10471 2 : : : cord-005453-4057qib7 10472 1 Biotest Biotest NNP cord-005453-4057qib7 10472 2 - - HYPH cord-005453-4057qib7 10472 3 Honaria Honaria NNP cord-005453-4057qib7 10472 4 P464 P464 NNP cord-005453-4057qib7 10472 5 Abstract Abstract NNP cord-005453-4057qib7 10472 6 withdrawn withdraw VBN cord-005453-4057qib7 10472 7 . . . cord-005453-4057qib7 10473 1 Background background NN cord-005453-4057qib7 10473 2 : : : cord-005453-4057qib7 10474 1 The the DT cord-005453-4057qib7 10474 2 risk risk NN cord-005453-4057qib7 10474 3 of of IN cord-005453-4057qib7 10474 4 fungal fungal JJ cord-005453-4057qib7 10474 5 infection infection NN cord-005453-4057qib7 10474 6 related relate VBN cord-005453-4057qib7 10474 7 to to IN cord-005453-4057qib7 10474 8 allogeneic allogeneic NN cord-005453-4057qib7 10474 9 transplantation transplantation NN cord-005453-4057qib7 10474 10 is be VBZ cord-005453-4057qib7 10474 11 a a DT cord-005453-4057qib7 10474 12 well well RB cord-005453-4057qib7 10474 13 - - HYPH cord-005453-4057qib7 10474 14 known know VBN cord-005453-4057qib7 10474 15 cause cause NN cord-005453-4057qib7 10474 16 of of IN cord-005453-4057qib7 10474 17 morbidity morbidity NN cord-005453-4057qib7 10474 18 and and CC cord-005453-4057qib7 10474 19 mortality mortality NN cord-005453-4057qib7 10474 20 . . . cord-005453-4057qib7 10475 1 The the DT cord-005453-4057qib7 10475 2 main main JJ cord-005453-4057qib7 10475 3 agents agent NNS cord-005453-4057qib7 10475 4 implicated implicate VBN cord-005453-4057qib7 10475 5 are be VBP cord-005453-4057qib7 10475 6 yeast yeast NN cord-005453-4057qib7 10475 7 during during IN cord-005453-4057qib7 10475 8 the the DT cord-005453-4057qib7 10475 9 neutropenic neutropenic JJ cord-005453-4057qib7 10475 10 period period NN cord-005453-4057qib7 10475 11 and and CC cord-005453-4057qib7 10475 12 filamentous filamentous JJ cord-005453-4057qib7 10475 13 fungi fungus NNS cord-005453-4057qib7 10475 14 after after IN cord-005453-4057qib7 10475 15 this this DT cord-005453-4057qib7 10475 16 period period NN cord-005453-4057qib7 10475 17 . . . cord-005453-4057qib7 10476 1 Methods method NNS cord-005453-4057qib7 10476 2 : : : cord-005453-4057qib7 10476 3 We -PRON- PRP cord-005453-4057qib7 10476 4 decided decide VBD cord-005453-4057qib7 10476 5 to to TO cord-005453-4057qib7 10476 6 evaluate evaluate VB cord-005453-4057qib7 10476 7 the the DT cord-005453-4057qib7 10476 8 effectiveness effectiveness NN cord-005453-4057qib7 10476 9 of of IN cord-005453-4057qib7 10476 10 a a DT cord-005453-4057qib7 10476 11 prophylactic prophylactic JJ cord-005453-4057qib7 10476 12 regimen regimen NN cord-005453-4057qib7 10476 13 containing contain VBG cord-005453-4057qib7 10476 14 fluconazole fluconazole NN cord-005453-4057qib7 10476 15 since since IN cord-005453-4057qib7 10476 16 day day NN cord-005453-4057qib7 10476 17 -3 -3 NNP cord-005453-4057qib7 10476 18 . . . cord-005453-4057qib7 10477 1 After after IN cord-005453-4057qib7 10477 2 discharge discharge NN cord-005453-4057qib7 10477 3 fluconazole fluconazole NNP cord-005453-4057qib7 10477 4 was be VBD cord-005453-4057qib7 10477 5 kept keep VBN cord-005453-4057qib7 10477 6 until until IN cord-005453-4057qib7 10477 7 day day NN cord-005453-4057qib7 10477 8 or or CC cord-005453-4057qib7 10477 9 75 75 CD cord-005453-4057qib7 10477 10 or or CC cord-005453-4057qib7 10477 11 switched switch VBN cord-005453-4057qib7 10477 12 to to IN cord-005453-4057qib7 10477 13 posaconazole posaconazole NNP cord-005453-4057qib7 10477 14 in in IN cord-005453-4057qib7 10477 15 high high JJ cord-005453-4057qib7 10477 16 - - HYPH cord-005453-4057qib7 10477 17 risk risk NN cord-005453-4057qib7 10477 18 patients patient NNS cord-005453-4057qib7 10477 19 . . . cord-005453-4057qib7 10478 1 Patients patient NNS cord-005453-4057qib7 10478 2 with with IN cord-005453-4057qib7 10478 3 GvHD GvHD NNP cord-005453-4057qib7 10478 4 under under IN cord-005453-4057qib7 10478 5 steroids steroid NNS cord-005453-4057qib7 10478 6 were be VBD cord-005453-4057qib7 10478 7 kept keep VBN cord-005453-4057qib7 10478 8 under under IN cord-005453-4057qib7 10478 9 prophylaxis prophylaxis NN cord-005453-4057qib7 10478 10 . . . cord-005453-4057qib7 10479 1 The the DT cord-005453-4057qib7 10479 2 group group NN cord-005453-4057qib7 10479 3 of of IN cord-005453-4057qib7 10479 4 high high JJ cord-005453-4057qib7 10479 5 risk risk NN cord-005453-4057qib7 10479 6 patients patient NNS cord-005453-4057qib7 10479 7 was be VBD cord-005453-4057qib7 10479 8 defined define VBN cord-005453-4057qib7 10479 9 by by IN cord-005453-4057qib7 10479 10 one one CD cord-005453-4057qib7 10479 11 of of IN cord-005453-4057qib7 10479 12 the the DT cord-005453-4057qib7 10479 13 following follow VBG cord-005453-4057qib7 10479 14 variables variable NNS cord-005453-4057qib7 10479 15 : : : cord-005453-4057qib7 10479 16 1-Non 1-Non NNP cord-005453-4057qib7 10479 17 related related JJ cord-005453-4057qib7 10479 18 donors donor NNS cord-005453-4057qib7 10479 19 2-ATG 2-atg CD cord-005453-4057qib7 10479 20 , , , cord-005453-4057qib7 10479 21 campath campath NN cord-005453-4057qib7 10479 22 or or CC cord-005453-4057qib7 10479 23 fludarabine fludarabine NN cord-005453-4057qib7 10479 24 in in IN cord-005453-4057qib7 10479 25 the the DT cord-005453-4057qib7 10479 26 conditioning conditioning NN cord-005453-4057qib7 10479 27 3-Presence 3-presence CD cord-005453-4057qib7 10479 28 of of IN cord-005453-4057qib7 10479 29 GvHD GvHD NNP cord-005453-4057qib7 10479 30 with with IN cord-005453-4057qib7 10479 31 need need NN cord-005453-4057qib7 10479 32 of of IN cord-005453-4057qib7 10479 33 steroids steroid NNS cord-005453-4057qib7 10479 34 above above IN cord-005453-4057qib7 10479 35 0.5 0.5 CD cord-005453-4057qib7 10479 36 mg mg NNP cord-005453-4057qib7 10479 37 / / SYM cord-005453-4057qib7 10479 38 kg kg NNP cord-005453-4057qib7 10480 1 We -PRON- PRP cord-005453-4057qib7 10480 2 have have VBP cord-005453-4057qib7 10480 3 analyzed analyze VBN cord-005453-4057qib7 10480 4 the the DT cord-005453-4057qib7 10480 5 patients patient NNS cord-005453-4057qib7 10480 6 submitted submit VBN cord-005453-4057qib7 10480 7 to to IN cord-005453-4057qib7 10480 8 alloBMT allobmt RB cord-005453-4057qib7 10480 9 during during IN cord-005453-4057qib7 10480 10 2016 2016 CD cord-005453-4057qib7 10480 11 and and CC cord-005453-4057qib7 10480 12 2017 2017 CD cord-005453-4057qib7 10480 13 . . . cord-005453-4057qib7 10481 1 All all DT cord-005453-4057qib7 10481 2 patients patient NNS cord-005453-4057qib7 10481 3 were be VBD cord-005453-4057qib7 10481 4 first first RB cord-005453-4057qib7 10481 5 admitted admit VBN cord-005453-4057qib7 10481 6 to to IN cord-005453-4057qib7 10481 7 an an DT cord-005453-4057qib7 10481 8 isolation isolation NN cord-005453-4057qib7 10481 9 room room NN cord-005453-4057qib7 10481 10 with with IN cord-005453-4057qib7 10481 11 HEPA HEPA NNP cord-005453-4057qib7 10481 12 filters filter NNS cord-005453-4057qib7 10481 13 . . . cord-005453-4057qib7 10482 1 Patients patient NNS cord-005453-4057qib7 10482 2 under under IN cord-005453-4057qib7 10482 3 secondary secondary JJ cord-005453-4057qib7 10482 4 prophylaxis prophylaxis NN cord-005453-4057qib7 10482 5 were be VBD cord-005453-4057qib7 10482 6 excluded exclude VBN cord-005453-4057qib7 10482 7 . . . cord-005453-4057qib7 10483 1 Breakthrough breakthrough JJ cord-005453-4057qib7 10483 2 fungal fungal JJ cord-005453-4057qib7 10483 3 infections infection NNS cord-005453-4057qib7 10483 4 during during IN cord-005453-4057qib7 10483 5 the the DT cord-005453-4057qib7 10483 6 first first JJ cord-005453-4057qib7 10483 7 year year NN cord-005453-4057qib7 10483 8 and and CC cord-005453-4057qib7 10483 9 toxicity toxicity NN cord-005453-4057qib7 10483 10 leading lead VBG cord-005453-4057qib7 10483 11 to to IN cord-005453-4057qib7 10483 12 discontinuation discontinuation NN cord-005453-4057qib7 10483 13 was be VBD cord-005453-4057qib7 10483 14 evaluated evaluate VBN cord-005453-4057qib7 10483 15 . . . cord-005453-4057qib7 10484 1 Results result NNS cord-005453-4057qib7 10484 2 : : : cord-005453-4057qib7 10485 1 Sixty sixty CD cord-005453-4057qib7 10485 2 six six CD cord-005453-4057qib7 10485 3 patients patient NNS cord-005453-4057qib7 10485 4 were be VBD cord-005453-4057qib7 10485 5 included include VBN cord-005453-4057qib7 10485 6 with with IN cord-005453-4057qib7 10485 7 67 67 CD cord-005453-4057qib7 10485 8 transplants transplant NNS cord-005453-4057qib7 10485 9 . . . cord-005453-4057qib7 10486 1 Male male JJ cord-005453-4057qib7 10486 2 / / SYM cord-005453-4057qib7 10486 3 female female JJ cord-005453-4057qib7 10486 4 ratio ratio NN cord-005453-4057qib7 10486 5 was be VBD cord-005453-4057qib7 10486 6 36/30 36/30 CD cord-005453-4057qib7 10486 7 . . . cord-005453-4057qib7 10487 1 The the DT cord-005453-4057qib7 10487 2 age age NN cord-005453-4057qib7 10487 3 range range NN cord-005453-4057qib7 10487 4 was be VBD cord-005453-4057qib7 10487 5 0.6 0.6 CD cord-005453-4057qib7 10487 6 - - SYM cord-005453-4057qib7 10487 7 64 64 CD cord-005453-4057qib7 10487 8 yo yo NN cord-005453-4057qib7 10487 9 with with IN cord-005453-4057qib7 10487 10 a a DT cord-005453-4057qib7 10487 11 median median NN cord-005453-4057qib7 10487 12 of of IN cord-005453-4057qib7 10487 13 37 37 CD cord-005453-4057qib7 10487 14 . . . cord-005453-4057qib7 10488 1 Malignant malignant JJ cord-005453-4057qib7 10488 2 ( ( -LRB- cord-005453-4057qib7 10488 3 53 53 CD cord-005453-4057qib7 10488 4 ) ) -RRB- cord-005453-4057qib7 10488 5 and and CC cord-005453-4057qib7 10488 6 nonmalignant nonmalignant NNP cord-005453-4057qib7 10488 7 ( ( -LRB- cord-005453-4057qib7 10488 8 13)diagnosis 13)diagnosis CD cord-005453-4057qib7 10488 9 were be VBD cord-005453-4057qib7 10488 10 included include VBN cord-005453-4057qib7 10488 11 . . . cord-005453-4057qib7 10489 1 Donor donor NN cord-005453-4057qib7 10489 2 type type NN cord-005453-4057qib7 10489 3 was be VBD cord-005453-4057qib7 10489 4 Related relate VBN cord-005453-4057qib7 10489 5 ( ( -LRB- cord-005453-4057qib7 10489 6 16 16 CD cord-005453-4057qib7 10489 7 ) ) -RRB- cord-005453-4057qib7 10489 8 Haploidentical Haploidentical NNP cord-005453-4057qib7 10489 9 ( ( -LRB- cord-005453-4057qib7 10489 10 9 9 CD cord-005453-4057qib7 10489 11 ) ) -RRB- cord-005453-4057qib7 10489 12 and and CC cord-005453-4057qib7 10489 13 non non JJ cord-005453-4057qib7 10489 14 - - JJ cord-005453-4057qib7 10489 15 related related JJ cord-005453-4057qib7 10489 16 ( ( -LRB- cord-005453-4057qib7 10489 17 42 42 CD cord-005453-4057qib7 10489 18 ) ) -RRB- cord-005453-4057qib7 10489 19 . . . cord-005453-4057qib7 10490 1 The the DT cord-005453-4057qib7 10490 2 conditioning conditioning NN cord-005453-4057qib7 10490 3 regimen regimen NN cord-005453-4057qib7 10490 4 includes include VBZ cord-005453-4057qib7 10490 5 ATG ATG NNP cord-005453-4057qib7 10490 6 in in IN cord-005453-4057qib7 10490 7 21 21 CD cord-005453-4057qib7 10490 8 , , , cord-005453-4057qib7 10490 9 campath campath NN cord-005453-4057qib7 10490 10 in in IN cord-005453-4057qib7 10490 11 5 5 CD cord-005453-4057qib7 10490 12 and and CC cord-005453-4057qib7 10490 13 fludarabine fludarabine NN cord-005453-4057qib7 10490 14 in in IN cord-005453-4057qib7 10490 15 41 41 CD cord-005453-4057qib7 10490 16 . . . cord-005453-4057qib7 10491 1 Fourteen fourteen CD cord-005453-4057qib7 10491 2 patients patient NNS cord-005453-4057qib7 10491 3 were be VBD cord-005453-4057qib7 10491 4 treated treat VBN cord-005453-4057qib7 10491 5 after after IN cord-005453-4057qib7 10491 6 discharge discharge NN cord-005453-4057qib7 10491 7 with with IN cord-005453-4057qib7 10491 8 fluconazole fluconazole NN cord-005453-4057qib7 10491 9 and and CC cord-005453-4057qib7 10491 10 52 52 CD cord-005453-4057qib7 10491 11 with with IN cord-005453-4057qib7 10491 12 posaconazole posaconazole NNP cord-005453-4057qib7 10491 13 . . . cord-005453-4057qib7 10492 1 Three three CD cord-005453-4057qib7 10492 2 patients patient NNS cord-005453-4057qib7 10492 3 fluconazole fluconazole NN cord-005453-4057qib7 10492 4 were be VBD cord-005453-4057qib7 10492 5 switched switch VBN cord-005453-4057qib7 10492 6 to to IN cord-005453-4057qib7 10492 7 micafungin micafungin NNP cord-005453-4057qib7 10492 8 for for IN cord-005453-4057qib7 10492 9 hepatic hepatic JJ cord-005453-4057qib7 10492 10 toxicity toxicity NN cord-005453-4057qib7 10492 11 , , , cord-005453-4057qib7 10492 12 two two CD cord-005453-4057qib7 10492 13 cases case NNS cord-005453-4057qib7 10492 14 to to IN cord-005453-4057qib7 10492 15 amphotericin amphotericin NNS cord-005453-4057qib7 10492 16 due due IN cord-005453-4057qib7 10492 17 to to IN cord-005453-4057qib7 10492 18 persistent persistent JJ cord-005453-4057qib7 10492 19 fever fever NN cord-005453-4057qib7 10492 20 and and CC cord-005453-4057qib7 10492 21 in in IN cord-005453-4057qib7 10492 22 one one CD cord-005453-4057qib7 10492 23 case case NN cord-005453-4057qib7 10492 24 to to IN cord-005453-4057qib7 10492 25 caspofungin caspofungin NNP cord-005453-4057qib7 10492 26 for for IN cord-005453-4057qib7 10492 27 a a DT cord-005453-4057qib7 10492 28 proven prove VBN cord-005453-4057qib7 10492 29 fungal fungal JJ cord-005453-4057qib7 10492 30 infection infection NN cord-005453-4057qib7 10492 31 ( ( -LRB- cord-005453-4057qib7 10492 32 candida candida NNP cord-005453-4057qib7 10492 33 parapsilosis parapsilosis NN cord-005453-4057qib7 10492 34 in in IN cord-005453-4057qib7 10492 35 blood blood NN cord-005453-4057qib7 10492 36 stream stream NN cord-005453-4057qib7 10492 37 in in IN cord-005453-4057qib7 10492 38 day day NN cord-005453-4057qib7 10492 39 +18 +18 CD cord-005453-4057qib7 10492 40 ) ) -RRB- cord-005453-4057qib7 10492 41 . . . cord-005453-4057qib7 10493 1 After after IN cord-005453-4057qib7 10493 2 discharge discharge NN cord-005453-4057qib7 10493 3 and and CC cord-005453-4057qib7 10493 4 during during IN cord-005453-4057qib7 10493 5 the the DT cord-005453-4057qib7 10493 6 first first JJ cord-005453-4057qib7 10493 7 year year NN cord-005453-4057qib7 10493 8 of of IN cord-005453-4057qib7 10493 9 follow follow NN cord-005453-4057qib7 10493 10 - - HYPH cord-005453-4057qib7 10493 11 up up NN cord-005453-4057qib7 10493 12 a a DT cord-005453-4057qib7 10493 13 single single JJ cord-005453-4057qib7 10493 14 case case NN cord-005453-4057qib7 10493 15 of of IN cord-005453-4057qib7 10493 16 possible possible JJ cord-005453-4057qib7 10493 17 fungal fungal JJ cord-005453-4057qib7 10493 18 infection infection NN cord-005453-4057qib7 10493 19 was be VBD cord-005453-4057qib7 10493 20 diagnosed diagnose VBN cord-005453-4057qib7 10493 21 , , , cord-005453-4057qib7 10493 22 in in IN cord-005453-4057qib7 10493 23 a a DT cord-005453-4057qib7 10493 24 patient patient NN cord-005453-4057qib7 10493 25 with with IN cord-005453-4057qib7 10493 26 GvHD GvHD NNP cord-005453-4057qib7 10493 27 with with IN cord-005453-4057qib7 10493 28 a a DT cord-005453-4057qib7 10493 29 lung lung NN cord-005453-4057qib7 10493 30 nodule nodule NN cord-005453-4057qib7 10493 31 . . . cord-005453-4057qib7 10494 1 Conclusions conclusion NNS cord-005453-4057qib7 10494 2 : : : cord-005453-4057qib7 10495 1 During during IN cord-005453-4057qib7 10495 2 the the DT cord-005453-4057qib7 10495 3 neutropenic neutropenic JJ cord-005453-4057qib7 10495 4 period period NN cord-005453-4057qib7 10495 5 after after IN cord-005453-4057qib7 10495 6 transplantation transplantation NN cord-005453-4057qib7 10495 7 the the DT cord-005453-4057qib7 10495 8 main main JJ cord-005453-4057qib7 10495 9 risk risk NN cord-005453-4057qib7 10495 10 of of IN cord-005453-4057qib7 10495 11 fungal fungal JJ cord-005453-4057qib7 10495 12 infection infection NN cord-005453-4057qib7 10495 13 is be VBZ cord-005453-4057qib7 10495 14 associated associate VBN cord-005453-4057qib7 10495 15 with with IN cord-005453-4057qib7 10495 16 candidiasis candidiasi NNS cord-005453-4057qib7 10495 17 . . . cord-005453-4057qib7 10496 1 The the DT cord-005453-4057qib7 10496 2 greatest great JJS cord-005453-4057qib7 10496 3 risk risk NN cord-005453-4057qib7 10496 4 of of IN cord-005453-4057qib7 10496 5 aspergillosis aspergillosis NN cord-005453-4057qib7 10496 6 occurs occur VBZ cord-005453-4057qib7 10496 7 later later RB cord-005453-4057qib7 10496 8 and and CC cord-005453-4057qib7 10496 9 have have VBP cord-005453-4057qib7 10496 10 a a DT cord-005453-4057qib7 10496 11 significant significant JJ cord-005453-4057qib7 10496 12 relation relation NN cord-005453-4057qib7 10496 13 with with IN cord-005453-4057qib7 10496 14 GvHD GvHD NNP cord-005453-4057qib7 10496 15 . . . cord-005453-4057qib7 10497 1 Except except IN cord-005453-4057qib7 10497 2 for for IN cord-005453-4057qib7 10497 3 candida candida NN cord-005453-4057qib7 10497 4 parapsilosis parapsilosis NNP cord-005453-4057qib7 10497 5 the the DT cord-005453-4057qib7 10497 6 main main JJ cord-005453-4057qib7 10497 7 source source NN cord-005453-4057qib7 10497 8 of of IN cord-005453-4057qib7 10497 9 yeasts yeast NNS cord-005453-4057qib7 10497 10 are be VBP cord-005453-4057qib7 10497 11 the the DT cord-005453-4057qib7 10497 12 GI GI NNP cord-005453-4057qib7 10497 13 tract tract NN cord-005453-4057qib7 10497 14 . . . cord-005453-4057qib7 10498 1 The the DT cord-005453-4057qib7 10498 2 main main JJ cord-005453-4057qib7 10498 3 source source NN cord-005453-4057qib7 10498 4 of of IN cord-005453-4057qib7 10498 5 aspergillus aspergillus NN cord-005453-4057qib7 10498 6 are be VBP cord-005453-4057qib7 10498 7 aerosolized aerosolize VBN cord-005453-4057qib7 10498 8 particles particle NNS cord-005453-4057qib7 10498 9 retained retain VBN cord-005453-4057qib7 10498 10 by by IN cord-005453-4057qib7 10498 11 HEPA HEPA NNP cord-005453-4057qib7 10498 12 filters filter NNS cord-005453-4057qib7 10498 13 . . . cord-005453-4057qib7 10499 1 In in IN cord-005453-4057qib7 10499 2 patients patient NNS cord-005453-4057qib7 10499 3 without without IN cord-005453-4057qib7 10499 4 a a DT cord-005453-4057qib7 10499 5 previous previous JJ cord-005453-4057qib7 10499 6 episode episode NN cord-005453-4057qib7 10499 7 of of IN cord-005453-4057qib7 10499 8 fungal fungal JJ cord-005453-4057qib7 10499 9 infection infection NN cord-005453-4057qib7 10499 10 the the DT cord-005453-4057qib7 10499 11 main main JJ cord-005453-4057qib7 10499 12 risk risk NN cord-005453-4057qib7 10499 13 of of IN cord-005453-4057qib7 10499 14 filamentous filamentous JJ cord-005453-4057qib7 10499 15 fungi fungus NNS cord-005453-4057qib7 10499 16 occurs occur VBZ cord-005453-4057qib7 10499 17 only only RB cord-005453-4057qib7 10499 18 after after IN cord-005453-4057qib7 10499 19 discharge discharge NN cord-005453-4057qib7 10499 20 . . . cord-005453-4057qib7 10500 1 We -PRON- PRP cord-005453-4057qib7 10500 2 conclude conclude VBP cord-005453-4057qib7 10500 3 that that IN cord-005453-4057qib7 10500 4 fluconazole fluconazole NN cord-005453-4057qib7 10500 5 alone alone RB cord-005453-4057qib7 10500 6 or or CC cord-005453-4057qib7 10500 7 followed follow VBN cord-005453-4057qib7 10500 8 by by IN cord-005453-4057qib7 10500 9 posaconazole posaconazole NNP cord-005453-4057qib7 10500 10 in in IN cord-005453-4057qib7 10500 11 high high JJ cord-005453-4057qib7 10500 12 risk risk NN cord-005453-4057qib7 10500 13 patients patient NNS cord-005453-4057qib7 10500 14 is be VBZ cord-005453-4057qib7 10500 15 a a DT cord-005453-4057qib7 10500 16 feasible feasible JJ cord-005453-4057qib7 10500 17 and and CC cord-005453-4057qib7 10500 18 effective effective JJ cord-005453-4057qib7 10500 19 regimen regimen NN cord-005453-4057qib7 10500 20 for for IN cord-005453-4057qib7 10500 21 primary primary JJ cord-005453-4057qib7 10500 22 prophylaxis prophylaxis NN cord-005453-4057qib7 10500 23 , , , cord-005453-4057qib7 10500 24 in in IN cord-005453-4057qib7 10500 25 allogeneic allogeneic NN cord-005453-4057qib7 10500 26 transplantation transplantation NN cord-005453-4057qib7 10500 27 . . . cord-005453-4057qib7 10501 1 Disclosure disclosure NN cord-005453-4057qib7 10501 2 Background background NN cord-005453-4057qib7 10501 3 : : : cord-005453-4057qib7 10501 4 BK BK NNP cord-005453-4057qib7 10501 5 virus virus NN cord-005453-4057qib7 10501 6 - - HYPH cord-005453-4057qib7 10501 7 associated associate VBN cord-005453-4057qib7 10501 8 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 10501 9 cystitis cystitis NN cord-005453-4057qib7 10501 10 ( ( -LRB- cord-005453-4057qib7 10501 11 BKV BKV NNP cord-005453-4057qib7 10501 12 - - HYPH cord-005453-4057qib7 10501 13 HC HC NNP cord-005453-4057qib7 10501 14 ) ) -RRB- cord-005453-4057qib7 10501 15 has have VBZ cord-005453-4057qib7 10501 16 emerged emerge VBN cord-005453-4057qib7 10501 17 as as IN cord-005453-4057qib7 10501 18 a a DT cord-005453-4057qib7 10501 19 serious serious JJ cord-005453-4057qib7 10501 20 infection infection NN cord-005453-4057qib7 10501 21 after after IN cord-005453-4057qib7 10501 22 hematopoietic hematopoietic JJ cord-005453-4057qib7 10501 23 stem stem NN cord-005453-4057qib7 10501 24 cell cell NN cord-005453-4057qib7 10501 25 transplantation transplantation NN cord-005453-4057qib7 10501 26 ( ( -LRB- cord-005453-4057qib7 10501 27 HSCT HSCT NNP cord-005453-4057qib7 10501 28 ) ) -RRB- cord-005453-4057qib7 10501 29 . . . cord-005453-4057qib7 10502 1 It -PRON- PRP cord-005453-4057qib7 10502 2 is be VBZ cord-005453-4057qib7 10502 3 characterized characterize VBN cord-005453-4057qib7 10502 4 by by IN cord-005453-4057qib7 10502 5 painful painful JJ cord-005453-4057qib7 10502 6 hematuria hematuria NN cord-005453-4057qib7 10502 7 due due IN cord-005453-4057qib7 10502 8 to to IN cord-005453-4057qib7 10502 9 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 10502 10 inflammation inflammation NN cord-005453-4057qib7 10502 11 of of IN cord-005453-4057qib7 10502 12 the the DT cord-005453-4057qib7 10502 13 urinary urinary JJ cord-005453-4057qib7 10502 14 bladder bladder NN cord-005453-4057qib7 10502 15 mucosa mucosa NN cord-005453-4057qib7 10502 16 , , , cord-005453-4057qib7 10502 17 this this DT cord-005453-4057qib7 10502 18 causes cause VBZ cord-005453-4057qib7 10502 19 significant significant JJ cord-005453-4057qib7 10502 20 morbidity morbidity NN cord-005453-4057qib7 10502 21 , , , cord-005453-4057qib7 10502 22 prolonged prolonged JJ cord-005453-4057qib7 10502 23 hospital hospital NN cord-005453-4057qib7 10502 24 care care NN cord-005453-4057qib7 10502 25 with with IN cord-005453-4057qib7 10502 26 extensive extensive JJ cord-005453-4057qib7 10502 27 nursing nursing NN cord-005453-4057qib7 10502 28 requirements requirement NNS cord-005453-4057qib7 10502 29 and and CC cord-005453-4057qib7 10502 30 increases increase NNS cord-005453-4057qib7 10502 31 in in IN cord-005453-4057qib7 10502 32 healthcare healthcare NN cord-005453-4057qib7 10502 33 costs cost NNS cord-005453-4057qib7 10502 34 . . . cord-005453-4057qib7 10503 1 The the DT cord-005453-4057qib7 10503 2 purpose purpose NN cord-005453-4057qib7 10503 3 of of IN cord-005453-4057qib7 10503 4 this this DT cord-005453-4057qib7 10503 5 study study NN cord-005453-4057qib7 10503 6 is be VBZ cord-005453-4057qib7 10503 7 to to TO cord-005453-4057qib7 10503 8 determine determine VB cord-005453-4057qib7 10503 9 the the DT cord-005453-4057qib7 10503 10 incidence incidence NN cord-005453-4057qib7 10503 11 , , , cord-005453-4057qib7 10503 12 risk risk NN cord-005453-4057qib7 10503 13 factors factor NNS cord-005453-4057qib7 10503 14 , , , cord-005453-4057qib7 10503 15 and and CC cord-005453-4057qib7 10503 16 duration duration NN cord-005453-4057qib7 10503 17 of of IN cord-005453-4057qib7 10503 18 treatment treatment NN cord-005453-4057qib7 10503 19 in in IN cord-005453-4057qib7 10503 20 our -PRON- PRP$ cord-005453-4057qib7 10503 21 center center NN cord-005453-4057qib7 10503 22 . . . cord-005453-4057qib7 10504 1 Methods method NNS cord-005453-4057qib7 10504 2 : : : cord-005453-4057qib7 10504 3 We -PRON- PRP cord-005453-4057qib7 10504 4 performed perform VBD cord-005453-4057qib7 10504 5 a a DT cord-005453-4057qib7 10504 6 retrospective retrospective JJ cord-005453-4057qib7 10504 7 review review NN cord-005453-4057qib7 10504 8 of of IN cord-005453-4057qib7 10504 9 HSCT HSCT NNP cord-005453-4057qib7 10504 10 patients patient NNS cord-005453-4057qib7 10504 11 at at IN cord-005453-4057qib7 10504 12 Luis Luis NNP cord-005453-4057qib7 10504 13 Calvo Calvo NNP cord-005453-4057qib7 10504 14 Mackenna Mackenna NNP cord-005453-4057qib7 10504 15 Children´s Children´s NNP cord-005453-4057qib7 10504 16 Hospital Hospital NNP cord-005453-4057qib7 10504 17 in in IN cord-005453-4057qib7 10504 18 Santiago Santiago NNP cord-005453-4057qib7 10504 19 , , , cord-005453-4057qib7 10504 20 Chile Chile NNP cord-005453-4057qib7 10504 21 diagnosed diagnose VBD cord-005453-4057qib7 10504 22 with with IN cord-005453-4057qib7 10504 23 BKV BKV NNP cord-005453-4057qib7 10504 24 - - HYPH cord-005453-4057qib7 10504 25 HC HC NNP cord-005453-4057qib7 10504 26 , , , cord-005453-4057qib7 10504 27 from from IN cord-005453-4057qib7 10504 28 1st 1st JJ cord-005453-4057qib7 10504 29 January January NNP cord-005453-4057qib7 10504 30 2016 2016 CD cord-005453-4057qib7 10504 31 to to IN cord-005453-4057qib7 10504 32 30th 30th JJ cord-005453-4057qib7 10504 33 November November NNP cord-005453-4057qib7 10504 34 2018 2018 CD cord-005453-4057qib7 10504 35 . . . cord-005453-4057qib7 10505 1 We -PRON- PRP cord-005453-4057qib7 10505 2 investigated investigate VBD cord-005453-4057qib7 10505 3 the the DT cord-005453-4057qib7 10505 4 incidence incidence NN cord-005453-4057qib7 10505 5 , , , cord-005453-4057qib7 10505 6 risk risk NN cord-005453-4057qib7 10505 7 factors factor NNS cord-005453-4057qib7 10505 8 and and CC cord-005453-4057qib7 10505 9 duration duration NN cord-005453-4057qib7 10505 10 of of IN cord-005453-4057qib7 10505 11 treatment treatment NN cord-005453-4057qib7 10505 12 of of IN cord-005453-4057qib7 10505 13 BKV BKV NNP cord-005453-4057qib7 10505 14 - - HYPH cord-005453-4057qib7 10505 15 HC HC NNP cord-005453-4057qib7 10505 16 in in IN cord-005453-4057qib7 10505 17 paediatric paediatric JJ cord-005453-4057qib7 10505 18 patients patient NNS cord-005453-4057qib7 10505 19 undergoing undergo VBG cord-005453-4057qib7 10505 20 HSCT HSCT NNP cord-005453-4057qib7 10505 21 over over IN cord-005453-4057qib7 10505 22 a a DT cord-005453-4057qib7 10505 23 35 35 CD cord-005453-4057qib7 10505 24 months month NNS cord-005453-4057qib7 10505 25 period period NN cord-005453-4057qib7 10505 26 . . . cord-005453-4057qib7 10506 1 BKV BKV NNP cord-005453-4057qib7 10506 2 - - HYPH cord-005453-4057qib7 10506 3 HC HC NNP cord-005453-4057qib7 10506 4 was be VBD cord-005453-4057qib7 10506 5 defined define VBN cord-005453-4057qib7 10506 6 as as IN cord-005453-4057qib7 10506 7 BK BK NNP cord-005453-4057qib7 10506 8 virus virus NN cord-005453-4057qib7 10506 9 ( ( -LRB- cord-005453-4057qib7 10506 10 BKV bkv NN cord-005453-4057qib7 10506 11 ) ) -RRB- cord-005453-4057qib7 10506 12 detection detection NN cord-005453-4057qib7 10506 13 in in IN cord-005453-4057qib7 10506 14 urine urine NN cord-005453-4057qib7 10506 15 by by IN cord-005453-4057qib7 10506 16 PCR PCR NNP cord-005453-4057qib7 10506 17 testing testing NN cord-005453-4057qib7 10506 18 in in IN cord-005453-4057qib7 10506 19 association association NN cord-005453-4057qib7 10506 20 with with IN cord-005453-4057qib7 10506 21 clinical clinical JJ cord-005453-4057qib7 10506 22 symptoms symptom NNS cord-005453-4057qib7 10506 23 and and CC cord-005453-4057qib7 10506 24 hematuria hematuria NN cord-005453-4057qib7 10506 25 grade grade NN cord-005453-4057qib7 10506 26 2 2 CD cord-005453-4057qib7 10506 27 or or CC cord-005453-4057qib7 10506 28 higher high JJR cord-005453-4057qib7 10506 29 . . . cord-005453-4057qib7 10507 1 Sixty sixty CD cord-005453-4057qib7 10507 2 - - HYPH cord-005453-4057qib7 10507 3 seven seven CD cord-005453-4057qib7 10507 4 patients patient NNS cord-005453-4057qib7 10507 5 were be VBD cord-005453-4057qib7 10507 6 trasplanted trasplante VBN cord-005453-4057qib7 10507 7 during during IN cord-005453-4057qib7 10507 8 this this DT cord-005453-4057qib7 10507 9 period period NN cord-005453-4057qib7 10507 10 . . . cord-005453-4057qib7 10508 1 Results result NNS cord-005453-4057qib7 10508 2 : : : cord-005453-4057qib7 10509 1 Eleven eleven CD cord-005453-4057qib7 10509 2 patients patient NNS cord-005453-4057qib7 10509 3 were be VBD cord-005453-4057qib7 10509 4 diagnosed diagnose VBN cord-005453-4057qib7 10509 5 with with IN cord-005453-4057qib7 10509 6 BKV BKV NNP cord-005453-4057qib7 10509 7 - - HYPH cord-005453-4057qib7 10509 8 HC HC NNP cord-005453-4057qib7 10509 9 at at IN cord-005453-4057qib7 10509 10 our -PRON- PRP$ cord-005453-4057qib7 10509 11 institution institution NN cord-005453-4057qib7 10509 12 , , , cord-005453-4057qib7 10509 13 only only RB cord-005453-4057qib7 10509 14 one one CD cord-005453-4057qib7 10509 15 with with IN cord-005453-4057qib7 10509 16 BK BK NNP cord-005453-4057qib7 10509 17 viremia viremia NN cord-005453-4057qib7 10509 18 . . . cord-005453-4057qib7 10510 1 The the DT cord-005453-4057qib7 10510 2 cumulative cumulative JJ cord-005453-4057qib7 10510 3 incidence incidence NN cord-005453-4057qib7 10510 4 of of IN cord-005453-4057qib7 10510 5 BKV BKV NNP cord-005453-4057qib7 10510 6 - - HYPH cord-005453-4057qib7 10510 7 HC HC NNP cord-005453-4057qib7 10510 8 in in IN cord-005453-4057qib7 10510 9 our -PRON- PRP$ cord-005453-4057qib7 10510 10 series series NN cord-005453-4057qib7 10510 11 was be VBD cord-005453-4057qib7 10510 12 16 16 CD cord-005453-4057qib7 10510 13 % % NN cord-005453-4057qib7 10510 14 . . . cord-005453-4057qib7 10511 1 All all DT cord-005453-4057qib7 10511 2 of of IN cord-005453-4057qib7 10511 3 them -PRON- PRP cord-005453-4057qib7 10511 4 were be VBD cord-005453-4057qib7 10511 5 treated treat VBN cord-005453-4057qib7 10511 6 with with IN cord-005453-4057qib7 10511 7 cidofovir cidofovir NNS cord-005453-4057qib7 10511 8 . . . cord-005453-4057qib7 10512 1 The the DT cord-005453-4057qib7 10512 2 median median JJ cord-005453-4057qib7 10512 3 age age NN cord-005453-4057qib7 10512 4 at at IN cord-005453-4057qib7 10512 5 diagnosis diagnosis NN cord-005453-4057qib7 10512 6 was be VBD cord-005453-4057qib7 10512 7 9 9 CD cord-005453-4057qib7 10512 8 years year NNS cord-005453-4057qib7 10512 9 old old JJ cord-005453-4057qib7 10513 1 ( ( -LRB- cord-005453-4057qib7 10513 2 range range NN cord-005453-4057qib7 10513 3 : : : cord-005453-4057qib7 10513 4 3 3 CD cord-005453-4057qib7 10513 5 - - SYM cord-005453-4057qib7 10513 6 13 13 CD cord-005453-4057qib7 10513 7 y.o y.o NNP cord-005453-4057qib7 10513 8 . . NNP cord-005453-4057qib7 10513 9 ) ) -RRB- cord-005453-4057qib7 10513 10 . . . cord-005453-4057qib7 10514 1 The the DT cord-005453-4057qib7 10514 2 median median JJ cord-005453-4057qib7 10514 3 time time NN cord-005453-4057qib7 10514 4 from from IN cord-005453-4057qib7 10514 5 HSCT HSCT NNP cord-005453-4057qib7 10514 6 to to IN cord-005453-4057qib7 10514 7 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 10514 8 cystitis cystitis NN cord-005453-4057qib7 10514 9 ( ( -LRB- cord-005453-4057qib7 10514 10 HC HC NNP cord-005453-4057qib7 10514 11 ) ) -RRB- cord-005453-4057qib7 10514 12 was be VBD cord-005453-4057qib7 10514 13 40 40 CD cord-005453-4057qib7 10514 14 days day NNS cord-005453-4057qib7 10515 1 ( ( -LRB- cord-005453-4057qib7 10515 2 range range NN cord-005453-4057qib7 10515 3 : : : cord-005453-4057qib7 10515 4 25 25 CD cord-005453-4057qib7 10515 5 - - SYM cord-005453-4057qib7 10515 6 240 240 CD cord-005453-4057qib7 10515 7 days day NNS cord-005453-4057qib7 10515 8 ) ) -RRB- cord-005453-4057qib7 10515 9 , , , cord-005453-4057qib7 10515 10 the the DT cord-005453-4057qib7 10515 11 median median JJ cord-005453-4057qib7 10515 12 length length NN cord-005453-4057qib7 10515 13 of of IN cord-005453-4057qib7 10515 14 treatment treatment NN cord-005453-4057qib7 10515 15 was be VBD cord-005453-4057qib7 10515 16 9 9 CD cord-005453-4057qib7 10515 17 weeks week NNS cord-005453-4057qib7 10516 1 ( ( -LRB- cord-005453-4057qib7 10516 2 range range NN cord-005453-4057qib7 10516 3 : : : cord-005453-4057qib7 10516 4 2 2 CD cord-005453-4057qib7 10516 5 - - SYM cord-005453-4057qib7 10516 6 36 36 CD cord-005453-4057qib7 10516 7 ) ) -RRB- cord-005453-4057qib7 10516 8 . . . cord-005453-4057qib7 10517 1 All all DT cord-005453-4057qib7 10517 2 patients patient NNS cord-005453-4057qib7 10517 3 received receive VBD cord-005453-4057qib7 10517 4 myeloablative myeloablative JJ cord-005453-4057qib7 10517 5 conditioning conditioning NN cord-005453-4057qib7 10517 6 regimens regimen NNS cord-005453-4057qib7 10517 7 and and CC cord-005453-4057qib7 10517 8 used use VBN cord-005453-4057qib7 10517 9 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 10517 10 ( ( -LRB- cord-005453-4057qib7 10517 11 100 100 CD cord-005453-4057qib7 10517 12 % % NN cord-005453-4057qib7 10517 13 ) ) -RRB- cord-005453-4057qib7 10517 14 ; ; : cord-005453-4057qib7 10517 15 ten ten CD cord-005453-4057qib7 10517 16 ( ( -LRB- cord-005453-4057qib7 10517 17 90 90 CD cord-005453-4057qib7 10517 18 % % NN cord-005453-4057qib7 10517 19 ) ) -RRB- cord-005453-4057qib7 10517 20 were be VBD cord-005453-4057qib7 10517 21 unrelated unrelated JJ cord-005453-4057qib7 10517 22 cord cord NN cord-005453-4057qib7 10517 23 blood blood NN cord-005453-4057qib7 10517 24 transplant transplant NN cord-005453-4057qib7 10517 25 recipients recipient NNS cord-005453-4057qib7 10517 26 and and CC cord-005453-4057qib7 10517 27 nine nine CD cord-005453-4057qib7 10517 28 ( ( -LRB- cord-005453-4057qib7 10517 29 81 81 CD cord-005453-4057qib7 10517 30 % % NN cord-005453-4057qib7 10517 31 ) ) -RRB- cord-005453-4057qib7 10517 32 used use VBD cord-005453-4057qib7 10517 33 antithymocyte antithymocyte NNP cord-005453-4057qib7 10517 34 globulin globulin NN cord-005453-4057qib7 10517 35 . . . cord-005453-4057qib7 10518 1 A a DT cord-005453-4057qib7 10518 2 concomitant concomitant JJ cord-005453-4057qib7 10518 3 viral viral JJ cord-005453-4057qib7 10518 4 reactivation reactivation NN cord-005453-4057qib7 10518 5 ( ( -LRB- cord-005453-4057qib7 10518 6 CMV CMV NNP cord-005453-4057qib7 10518 7 / / SYM cord-005453-4057qib7 10518 8 VH6 VH6 NNP cord-005453-4057qib7 10518 9 ) ) -RRB- cord-005453-4057qib7 10518 10 was be VBD cord-005453-4057qib7 10518 11 demonstrated demonstrate VBN cord-005453-4057qib7 10518 12 in in IN cord-005453-4057qib7 10518 13 six six CD cord-005453-4057qib7 10518 14 ( ( -LRB- cord-005453-4057qib7 10518 15 56 56 CD cord-005453-4057qib7 10518 16 % % NN cord-005453-4057qib7 10518 17 ) ) -RRB- cord-005453-4057qib7 10518 18 patients patient NNS cord-005453-4057qib7 10518 19 . . . cord-005453-4057qib7 10519 1 No no DT cord-005453-4057qib7 10519 2 patient patient NN cord-005453-4057qib7 10519 3 died die VBD cord-005453-4057qib7 10519 4 due due IN cord-005453-4057qib7 10519 5 to to IN cord-005453-4057qib7 10519 6 BKV BKV NNP cord-005453-4057qib7 10519 7 - - HYPH cord-005453-4057qib7 10519 8 HC HC NNP cord-005453-4057qib7 10519 9 or or CC cord-005453-4057qib7 10519 10 its -PRON- PRP$ cord-005453-4057qib7 10519 11 complications complication NNS cord-005453-4057qib7 10519 12 , , , cord-005453-4057qib7 10519 13 but but CC cord-005453-4057qib7 10519 14 in in IN cord-005453-4057qib7 10519 15 the the DT cord-005453-4057qib7 10519 16 follow follow NN cord-005453-4057qib7 10519 17 up up RP cord-005453-4057qib7 10519 18 three three CD cord-005453-4057qib7 10519 19 patients patient NNS cord-005453-4057qib7 10519 20 died die VBD cord-005453-4057qib7 10519 21 , , , cord-005453-4057qib7 10519 22 one one CD cord-005453-4057qib7 10519 23 in in IN cord-005453-4057qib7 10519 24 relapse relapse NN cord-005453-4057qib7 10519 25 and and CC cord-005453-4057qib7 10519 26 two two CD cord-005453-4057qib7 10519 27 of of IN cord-005453-4057qib7 10519 28 other other JJ cord-005453-4057qib7 10519 29 post post NN cord-005453-4057qib7 10519 30 transplant´s transplant´s NNP cord-005453-4057qib7 10519 31 complications complication NNS cord-005453-4057qib7 10519 32 . . . cord-005453-4057qib7 10520 1 Conclusions conclusion NNS cord-005453-4057qib7 10520 2 : : : cord-005453-4057qib7 10521 1 BKV BKV NNP cord-005453-4057qib7 10521 2 - - HYPH cord-005453-4057qib7 10521 3 HC HC NNP cord-005453-4057qib7 10521 4 is be VBZ cord-005453-4057qib7 10521 5 the the DT cord-005453-4057qib7 10521 6 result result NN cord-005453-4057qib7 10521 7 of of IN cord-005453-4057qib7 10521 8 a a DT cord-005453-4057qib7 10521 9 complex complex JJ cord-005453-4057qib7 10521 10 interaction interaction NN cord-005453-4057qib7 10521 11 between between IN cord-005453-4057qib7 10521 12 patient patient JJ cord-005453-4057qib7 10521 13 characteristics characteristic NNS cord-005453-4057qib7 10521 14 , , , cord-005453-4057qib7 10521 15 donor donor NN cord-005453-4057qib7 10521 16 type type NN cord-005453-4057qib7 10521 17 and and CC cord-005453-4057qib7 10521 18 conditioning conditioning NN cord-005453-4057qib7 10521 19 regimen regimen NN cord-005453-4057qib7 10521 20 intensity intensity NN cord-005453-4057qib7 10521 21 . . . cord-005453-4057qib7 10522 1 These these DT cord-005453-4057qib7 10522 2 patients patient NNS cord-005453-4057qib7 10522 3 experienced experience VBD cord-005453-4057qib7 10522 4 significant significant JJ cord-005453-4057qib7 10522 5 morbidity morbidity NN cord-005453-4057qib7 10522 6 and and CC cord-005453-4057qib7 10522 7 prolonged prolong VBN cord-005453-4057qib7 10522 8 treatment treatment NN cord-005453-4057qib7 10522 9 . . . cord-005453-4057qib7 10523 1 In in IN cord-005453-4057qib7 10523 2 our -PRON- PRP$ cord-005453-4057qib7 10523 3 cohort cohort JJ cord-005453-4057qib7 10523 4 BKV BKV NNP cord-005453-4057qib7 10523 5 - - HYPH cord-005453-4057qib7 10523 6 HC HC NNP cord-005453-4057qib7 10523 7 of of IN cord-005453-4057qib7 10523 8 all all DT cord-005453-4057qib7 10523 9 patients patient NNS cord-005453-4057qib7 10523 10 but but CC cord-005453-4057qib7 10523 11 one one CD cord-005453-4057qib7 10523 12 were be VBD cord-005453-4057qib7 10523 13 transplanted transplant VBN cord-005453-4057qib7 10523 14 with with IN cord-005453-4057qib7 10523 15 an an DT cord-005453-4057qib7 10523 16 unrelated unrelated JJ cord-005453-4057qib7 10523 17 umbilical umbilical JJ cord-005453-4057qib7 10523 18 cord cord NN cord-005453-4057qib7 10523 19 blood blood NN cord-005453-4057qib7 10523 20 unit unit NN cord-005453-4057qib7 10523 21 , , , cord-005453-4057qib7 10523 22 all all DT cord-005453-4057qib7 10523 23 of of IN cord-005453-4057qib7 10523 24 them -PRON- PRP cord-005453-4057qib7 10523 25 received receive VBD cord-005453-4057qib7 10523 26 myeloablative myeloablative JJ cord-005453-4057qib7 10523 27 conditioning conditioning NN cord-005453-4057qib7 10523 28 regimen regimen NN cord-005453-4057qib7 10523 29 with with IN cord-005453-4057qib7 10523 30 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 10523 31 and and CC cord-005453-4057qib7 10523 32 most most JJS cord-005453-4057qib7 10523 33 of of IN cord-005453-4057qib7 10523 34 them -PRON- PRP cord-005453-4057qib7 10523 35 received receive VBD cord-005453-4057qib7 10523 36 anti anti JJ cord-005453-4057qib7 10523 37 - - JJ cord-005453-4057qib7 10523 38 thymocyte thymocyte JJ cord-005453-4057qib7 10523 39 globulin globulin NN cord-005453-4057qib7 10523 40 . . . cord-005453-4057qib7 10524 1 We -PRON- PRP cord-005453-4057qib7 10524 2 also also RB cord-005453-4057qib7 10524 3 observed observe VBD cord-005453-4057qib7 10524 4 frequently frequently RB cord-005453-4057qib7 10524 5 co co VBD cord-005453-4057qib7 10524 6 - - NN cord-005453-4057qib7 10524 7 existence existence NN cord-005453-4057qib7 10524 8 of of IN cord-005453-4057qib7 10524 9 viral viral JJ cord-005453-4057qib7 10524 10 infections infection NNS cord-005453-4057qib7 10524 11 from from IN cord-005453-4057qib7 10524 12 Herpes Herpes NNP cord-005453-4057qib7 10524 13 family family NN cord-005453-4057qib7 10524 14 as as IN cord-005453-4057qib7 10524 15 CMV CMV NNP cord-005453-4057qib7 10524 16 and and CC cord-005453-4057qib7 10524 17 VH6 VH6 NNP cord-005453-4057qib7 10524 18 . . . cord-005453-4057qib7 10525 1 The the DT cord-005453-4057qib7 10525 2 main main JJ cord-005453-4057qib7 10525 3 limitations limitation NNS cord-005453-4057qib7 10525 4 of of IN cord-005453-4057qib7 10525 5 this this DT cord-005453-4057qib7 10525 6 work work NN cord-005453-4057qib7 10525 7 are be VBP cord-005453-4057qib7 10525 8 its -PRON- PRP$ cord-005453-4057qib7 10525 9 retrospective retrospective JJ cord-005453-4057qib7 10525 10 nature nature NN cord-005453-4057qib7 10525 11 and and CC cord-005453-4057qib7 10525 12 it´s it´s NN cord-005453-4057qib7 10525 13 from from IN cord-005453-4057qib7 10525 14 a a DT cord-005453-4057qib7 10525 15 single single JJ cord-005453-4057qib7 10525 16 center center NN cord-005453-4057qib7 10525 17 . . . cord-005453-4057qib7 10526 1 More More JJR cord-005453-4057qib7 10526 2 studies study NNS cord-005453-4057qib7 10526 3 are be VBP cord-005453-4057qib7 10526 4 necessary necessary JJ cord-005453-4057qib7 10526 5 to to TO cord-005453-4057qib7 10526 6 better better RB cord-005453-4057qib7 10526 7 understand understand VB cord-005453-4057qib7 10526 8 the the DT cord-005453-4057qib7 10526 9 epidemiology epidemiology NN cord-005453-4057qib7 10526 10 and and CC cord-005453-4057qib7 10526 11 risk risk NN cord-005453-4057qib7 10526 12 factor factor NN cord-005453-4057qib7 10526 13 associated associate VBN cord-005453-4057qib7 10526 14 with with IN cord-005453-4057qib7 10526 15 BKV BKV NNP cord-005453-4057qib7 10526 16 - - HYPH cord-005453-4057qib7 10526 17 HC HC NNP cord-005453-4057qib7 10526 18 and and CC cord-005453-4057qib7 10526 19 the the DT cord-005453-4057qib7 10526 20 morbidities morbidity NNS cord-005453-4057qib7 10526 21 associated associate VBN cord-005453-4057qib7 10526 22 with with IN cord-005453-4057qib7 10526 23 its -PRON- PRP$ cord-005453-4057qib7 10526 24 treatment treatment NN cord-005453-4057qib7 10526 25 . . . cord-005453-4057qib7 10527 1 Disclosure disclosure NN cord-005453-4057qib7 10527 2 : : : cord-005453-4057qib7 10527 3 Nothing nothing NN cord-005453-4057qib7 10527 4 to to TO cord-005453-4057qib7 10527 5 declare declare VB cord-005453-4057qib7 10527 6 How how WRB cord-005453-4057qib7 10527 7 we -PRON- PRP cord-005453-4057qib7 10527 8 manage manage VBP cord-005453-4057qib7 10527 9 HHV-6 HHV-6 NNP cord-005453-4057qib7 10527 10 reactivation reactivation NN cord-005453-4057qib7 10527 11 in in IN cord-005453-4057qib7 10527 12 the the DT cord-005453-4057qib7 10527 13 posttransplant posttransplant NN cord-005453-4057qib7 10527 14 setting set VBG cord-005453-4057qib7 10527 15 Oscar Oscar NNP cord-005453-4057qib7 10527 16 Borsani Borsani NNP cord-005453-4057qib7 10527 17 1 1 CD cord-005453-4057qib7 10527 18 , , , cord-005453-4057qib7 10527 19 Anna Anna NNP cord-005453-4057qib7 10527 20 Amelia Amelia NNP cord-005453-4057qib7 10527 21 Colombo Colombo NNP cord-005453-4057qib7 10527 22 1 1 CD cord-005453-4057qib7 10527 23 , , , cord-005453-4057qib7 10527 24 Daniela Daniela NNP cord-005453-4057qib7 10527 25 Caldera Caldera NNP cord-005453-4057qib7 10527 26 1 1 CD cord-005453-4057qib7 10527 27 , , , cord-005453-4057qib7 10527 28 Paolo Paolo NNP cord-005453-4057qib7 10527 29 Bernasconi Bernasconi NNP cord-005453-4057qib7 10527 30 1 1 CD cord-005453-4057qib7 10527 31 1 1 CD cord-005453-4057qib7 10527 32 University University NNP cord-005453-4057qib7 10527 33 of of IN cord-005453-4057qib7 10527 34 Pavia Pavia NNP cord-005453-4057qib7 10527 35 , , , cord-005453-4057qib7 10527 36 San San NNP cord-005453-4057qib7 10527 37 Matteo Matteo NNP cord-005453-4057qib7 10527 38 Hospital Hospital NNP cord-005453-4057qib7 10527 39 , , , cord-005453-4057qib7 10527 40 Pavia Pavia NNP cord-005453-4057qib7 10527 41 , , , cord-005453-4057qib7 10527 42 Italy Italy NNP cord-005453-4057qib7 10527 43 Background Background NNP cord-005453-4057qib7 10527 44 : : : cord-005453-4057qib7 10528 1 HHV-6 HHV-6 NNP cord-005453-4057qib7 10528 2 encephalitis encephalitis RB cord-005453-4057qib7 10528 3 is be VBZ cord-005453-4057qib7 10528 4 a a DT cord-005453-4057qib7 10528 5 life life NN cord-005453-4057qib7 10528 6 - - HYPH cord-005453-4057qib7 10528 7 threatening threaten VBG cord-005453-4057qib7 10528 8 complication complication NN cord-005453-4057qib7 10528 9 in in IN cord-005453-4057qib7 10528 10 the the DT cord-005453-4057qib7 10528 11 post post JJ cord-005453-4057qib7 10528 12 - - JJ cord-005453-4057qib7 10528 13 transplant transplant JJ cord-005453-4057qib7 10528 14 setting setting NN cord-005453-4057qib7 10528 15 and and CC cord-005453-4057qib7 10528 16 it -PRON- PRP cord-005453-4057qib7 10528 17 develops develop VBZ cord-005453-4057qib7 10528 18 in in IN cord-005453-4057qib7 10528 19 about about RB cord-005453-4057qib7 10528 20 1 1 CD cord-005453-4057qib7 10528 21 % % NN cord-005453-4057qib7 10528 22 of of IN cord-005453-4057qib7 10528 23 patients patient NNS cord-005453-4057qib7 10528 24 receiving receive VBG cord-005453-4057qib7 10528 25 traditional traditional JJ cord-005453-4057qib7 10528 26 HSCT HSCT NNP cord-005453-4057qib7 10528 27 . . . cord-005453-4057qib7 10529 1 Several several JJ cord-005453-4057qib7 10529 2 risk risk NN cord-005453-4057qib7 10529 3 factors factor NNS cord-005453-4057qib7 10529 4 were be VBD cord-005453-4057qib7 10529 5 described describe VBN cord-005453-4057qib7 10529 6 . . . cord-005453-4057qib7 10530 1 A a DT cord-005453-4057qib7 10530 2 differential differential JJ cord-005453-4057qib7 10530 3 diagnosis diagnosis NN cord-005453-4057qib7 10530 4 between between IN cord-005453-4057qib7 10530 5 HHV-6 HHV-6 NNP cord-005453-4057qib7 10530 6 encephalitis encephalitis JJ cord-005453-4057qib7 10530 7 and and CC cord-005453-4057qib7 10530 8 other other JJ cord-005453-4057qib7 10530 9 neurological neurological JJ cord-005453-4057qib7 10530 10 complications complication NNS cord-005453-4057qib7 10530 11 is be VBZ cord-005453-4057qib7 10530 12 extremely extremely RB cord-005453-4057qib7 10530 13 important important JJ cord-005453-4057qib7 10530 14 but but CC cord-005453-4057qib7 10530 15 often often RB cord-005453-4057qib7 10530 16 not not RB cord-005453-4057qib7 10530 17 - - HYPH cord-005453-4057qib7 10530 18 easy easy JJ cord-005453-4057qib7 10530 19 to to TO cord-005453-4057qib7 10530 20 achieve achieve VB cord-005453-4057qib7 10530 21 because because IN cord-005453-4057qib7 10530 22 of of IN cord-005453-4057qib7 10530 23 the the DT cord-005453-4057qib7 10530 24 highly highly RB cord-005453-4057qib7 10530 25 heterogeneous heterogeneous JJ cord-005453-4057qib7 10530 26 clinical clinical JJ cord-005453-4057qib7 10530 27 and and CC cord-005453-4057qib7 10530 28 radiological radiological JJ cord-005453-4057qib7 10530 29 features feature NNS cord-005453-4057qib7 10530 30 and and CC cord-005453-4057qib7 10530 31 complexity complexity NN cord-005453-4057qib7 10530 32 of of IN cord-005453-4057qib7 10530 33 interpretation interpretation NN cord-005453-4057qib7 10530 34 , , , cord-005453-4057qib7 10530 35 especially especially RB cord-005453-4057qib7 10530 36 in in IN cord-005453-4057qib7 10530 37 transplanted transplanted JJ cord-005453-4057qib7 10530 38 patients patient NNS cord-005453-4057qib7 10530 39 . . . cord-005453-4057qib7 10531 1 Here here RB cord-005453-4057qib7 10531 2 we -PRON- PRP cord-005453-4057qib7 10531 3 described describe VBD cord-005453-4057qib7 10531 4 vignettes vignette NNS cord-005453-4057qib7 10531 5 that that WDT cord-005453-4057qib7 10531 6 represent represent VBP cord-005453-4057qib7 10531 7 and and CC cord-005453-4057qib7 10531 8 highlight highlight VBP cord-005453-4057qib7 10531 9 distinct distinct JJ cord-005453-4057qib7 10531 10 problems problem NNS cord-005453-4057qib7 10531 11 in in IN cord-005453-4057qib7 10531 12 the the DT cord-005453-4057qib7 10531 13 diagnosis diagnosis NN cord-005453-4057qib7 10531 14 and and CC cord-005453-4057qib7 10531 15 management management NN cord-005453-4057qib7 10531 16 of of IN cord-005453-4057qib7 10531 17 transplanted transplanted JJ cord-005453-4057qib7 10531 18 patients patient NNS cord-005453-4057qib7 10531 19 with with IN cord-005453-4057qib7 10531 20 suspected suspect VBN cord-005453-4057qib7 10531 21 HHV-6 HHV-6 NNP cord-005453-4057qib7 10531 22 reactivation reactivation NN cord-005453-4057qib7 10531 23 . . . cord-005453-4057qib7 10532 1 Methods method NNS cord-005453-4057qib7 10532 2 : : : cord-005453-4057qib7 10532 3 We -PRON- PRP cord-005453-4057qib7 10532 4 collected collect VBD cord-005453-4057qib7 10532 5 the the DT cord-005453-4057qib7 10532 6 clinical clinical JJ cord-005453-4057qib7 10532 7 , , , cord-005453-4057qib7 10532 8 laboratory laboratory NN cord-005453-4057qib7 10532 9 and and CC cord-005453-4057qib7 10532 10 radiological radiological JJ cord-005453-4057qib7 10532 11 ( ( -LRB- cord-005453-4057qib7 10532 12 electroencephalogram electroencephalogram NN cord-005453-4057qib7 10532 13 , , , cord-005453-4057qib7 10532 14 brain brain NN cord-005453-4057qib7 10532 15 MRI MRI NNP cord-005453-4057qib7 10532 16 and and CC cord-005453-4057qib7 10532 17 brain brain NN cord-005453-4057qib7 10532 18 CT CT NNP cord-005453-4057qib7 10532 19 ) ) -RRB- cord-005453-4057qib7 10532 20 data datum NNS cord-005453-4057qib7 10532 21 of of IN cord-005453-4057qib7 10532 22 transplanted transplanted JJ cord-005453-4057qib7 10532 23 patients patient NNS cord-005453-4057qib7 10532 24 who who WP cord-005453-4057qib7 10532 25 developed develop VBD cord-005453-4057qib7 10532 26 a a DT cord-005453-4057qib7 10532 27 neurological neurological JJ cord-005453-4057qib7 10532 28 syndrome syndrome NN cord-005453-4057qib7 10532 29 suspected suspect VBN cord-005453-4057qib7 10532 30 for for IN cord-005453-4057qib7 10532 31 HHV-6 HHV-6 NNP cord-005453-4057qib7 10532 32 reactivation reactivation NN cord-005453-4057qib7 10532 33 . . . cord-005453-4057qib7 10533 1 HHV-6 HHV-6 NNP cord-005453-4057qib7 10533 2 was be VBD cord-005453-4057qib7 10533 3 detected detect VBN cord-005453-4057qib7 10533 4 on on IN cord-005453-4057qib7 10533 5 serum serum NN cord-005453-4057qib7 10533 6 and and CC cord-005453-4057qib7 10533 7 CSF CSF NNP cord-005453-4057qib7 10533 8 using use VBG cord-005453-4057qib7 10533 9 RT RT NNP cord-005453-4057qib7 10533 10 - - HYPH cord-005453-4057qib7 10533 11 qPCR qPCR NNP cord-005453-4057qib7 10533 12 . . . cord-005453-4057qib7 10534 1 Results result NNS cord-005453-4057qib7 10534 2 : : : cord-005453-4057qib7 10534 3 1 1 LS cord-005453-4057qib7 10534 4 ) ) -RRB- cord-005453-4057qib7 10535 1 A a DT cord-005453-4057qib7 10535 2 61-years 61-years CD cord-005453-4057qib7 10535 3 - - HYPH cord-005453-4057qib7 10535 4 old old JJ cord-005453-4057qib7 10535 5 patient patient NN cord-005453-4057qib7 10535 6 developed develop VBD cord-005453-4057qib7 10535 7 a a DT cord-005453-4057qib7 10535 8 diffuse diffuse JJ cord-005453-4057qib7 10535 9 erythema erythema NN cord-005453-4057qib7 10535 10 and and CC cord-005453-4057qib7 10535 11 subsequent subsequent JJ cord-005453-4057qib7 10535 12 encephalitic encephalitic JJ cord-005453-4057qib7 10535 13 syndrome syndrome NN cord-005453-4057qib7 10535 14 following follow VBG cord-005453-4057qib7 10535 15 HSCT HSCT NNP cord-005453-4057qib7 10535 16 . . . cord-005453-4057qib7 10536 1 The the DT cord-005453-4057qib7 10536 2 brain brain NN cord-005453-4057qib7 10536 3 MRI MRI NNP cord-005453-4057qib7 10536 4 revealed reveal VBD cord-005453-4057qib7 10536 5 clear clear JJ cord-005453-4057qib7 10536 6 signs sign NNS cord-005453-4057qib7 10536 7 of of IN cord-005453-4057qib7 10536 8 limbic limbic JJ cord-005453-4057qib7 10536 9 encephalitic encephalitic JJ cord-005453-4057qib7 10536 10 and and CC cord-005453-4057qib7 10536 11 searching search VBG cord-005453-4057qib7 10536 12 for for IN cord-005453-4057qib7 10536 13 HHV-6 HHV-6 NNP cord-005453-4057qib7 10536 14 on on IN cord-005453-4057qib7 10536 15 serum serum NN cord-005453-4057qib7 10536 16 and and CC cord-005453-4057qib7 10536 17 CSF CSF NNP cord-005453-4057qib7 10536 18 revealed reveal VBD cord-005453-4057qib7 10536 19 150.000 150.000 CD cord-005453-4057qib7 10536 20 copies copy NNS cord-005453-4057qib7 10536 21 / / SYM cord-005453-4057qib7 10536 22 mL ml NN cord-005453-4057qib7 10536 23 and and CC cord-005453-4057qib7 10536 24 220.000 220.000 CD cord-005453-4057qib7 10536 25 copies copy NNS cord-005453-4057qib7 10536 26 / / SYM cord-005453-4057qib7 10536 27 ml ml NN cord-005453-4057qib7 10536 28 respectively respectively RB cord-005453-4057qib7 10536 29 . . . cord-005453-4057qib7 10537 1 An an DT cord-005453-4057qib7 10537 2 antiviral antiviral JJ cord-005453-4057qib7 10537 3 therapy therapy NN cord-005453-4057qib7 10537 4 was be VBD cord-005453-4057qib7 10537 5 started start VBN cord-005453-4057qib7 10537 6 but but CC cord-005453-4057qib7 10537 7 no no DT cord-005453-4057qib7 10537 8 clinical clinical JJ cord-005453-4057qib7 10537 9 benefit benefit NN cord-005453-4057qib7 10537 10 was be VBD cord-005453-4057qib7 10537 11 achieved achieve VBN cord-005453-4057qib7 10537 12 . . . cord-005453-4057qib7 10538 1 2 2 LS cord-005453-4057qib7 10538 2 ) ) -RRB- cord-005453-4057qib7 10539 1 A a DT cord-005453-4057qib7 10539 2 59-years 59-years CD cord-005453-4057qib7 10539 3 - - HYPH cord-005453-4057qib7 10539 4 old old JJ cord-005453-4057qib7 10539 5 patient patient NN cord-005453-4057qib7 10539 6 developed develop VBD cord-005453-4057qib7 10539 7 a a DT cord-005453-4057qib7 10539 8 typical typical JJ cord-005453-4057qib7 10539 9 neurological neurological JJ cord-005453-4057qib7 10539 10 syndrome syndrome NN cord-005453-4057qib7 10539 11 without without IN cord-005453-4057qib7 10539 12 brain brain NN cord-005453-4057qib7 10539 13 MRI MRI NNP cord-005453-4057qib7 10539 14 findings finding NNS cord-005453-4057qib7 10539 15 of of IN cord-005453-4057qib7 10539 16 encephalitis encephalitis NN cord-005453-4057qib7 10539 17 and and CC cord-005453-4057qib7 10539 18 with with IN cord-005453-4057qib7 10539 19 no no DT cord-005453-4057qib7 10539 20 evidence evidence NN cord-005453-4057qib7 10539 21 of of IN cord-005453-4057qib7 10539 22 skin skin NN cord-005453-4057qib7 10539 23 involvement involvement NN cord-005453-4057qib7 10539 24 . . . cord-005453-4057qib7 10540 1 The the DT cord-005453-4057qib7 10540 2 lumbar lumbar NN cord-005453-4057qib7 10540 3 puncture puncture NN cord-005453-4057qib7 10540 4 and and CC cord-005453-4057qib7 10540 5 CSF CSF NNP cord-005453-4057qib7 10540 6 analysis analysis NN cord-005453-4057qib7 10540 7 showed show VBD cord-005453-4057qib7 10540 8 a a DT cord-005453-4057qib7 10540 9 total total NN cord-005453-4057qib7 10540 10 of of IN cord-005453-4057qib7 10540 11 49.200 49.200 CD cord-005453-4057qib7 10540 12 HHV-6 HHV-6 NNP cord-005453-4057qib7 10540 13 DNA DNA NNP cord-005453-4057qib7 10540 14 copies copy NNS cord-005453-4057qib7 10540 15 / / SYM cord-005453-4057qib7 10540 16 mL. mL. NNP cord-005453-4057qib7 10540 17 Antiviral antiviral JJ cord-005453-4057qib7 10540 18 therapy therapy NN cord-005453-4057qib7 10540 19 with with IN cord-005453-4057qib7 10540 20 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 10540 21 and and CC cord-005453-4057qib7 10540 22 Foscarnet Foscarnet NNP cord-005453-4057qib7 10540 23 was be VBD cord-005453-4057qib7 10540 24 promptly promptly RB cord-005453-4057qib7 10540 25 started start VBN cord-005453-4057qib7 10540 26 with with IN cord-005453-4057qib7 10540 27 clinical clinical JJ cord-005453-4057qib7 10540 28 improvement improvement NN cord-005453-4057qib7 10540 29 and and CC cord-005453-4057qib7 10540 30 a a DT cord-005453-4057qib7 10540 31 drastically drastically JJ cord-005453-4057qib7 10540 32 reduction reduction NN cord-005453-4057qib7 10540 33 of of IN cord-005453-4057qib7 10540 34 HHV-6 HHV-6 NNP cord-005453-4057qib7 10540 35 DNA DNA NNP cord-005453-4057qib7 10540 36 on on IN cord-005453-4057qib7 10540 37 both both CC cord-005453-4057qib7 10540 38 CSF CSF NNP cord-005453-4057qib7 10540 39 and and CC cord-005453-4057qib7 10540 40 serum serum NN cord-005453-4057qib7 10540 41 . . . cord-005453-4057qib7 10541 1 A a DT cord-005453-4057qib7 10541 2 new new JJ cord-005453-4057qib7 10541 3 brain brain NN cord-005453-4057qib7 10542 1 MRI MRI NNP cord-005453-4057qib7 10542 2 revealed reveal VBD cord-005453-4057qib7 10542 3 an an DT cord-005453-4057qib7 10542 4 acute acute JJ cord-005453-4057qib7 10542 5 limbic limbic JJ cord-005453-4057qib7 10542 6 encephalitis encephalitis RB cord-005453-4057qib7 10542 7 . . . cord-005453-4057qib7 10543 1 3 3 LS cord-005453-4057qib7 10543 2 ) ) -RRB- cord-005453-4057qib7 10544 1 A a DT cord-005453-4057qib7 10544 2 slight slight JJ cord-005453-4057qib7 10544 3 neurological neurological JJ cord-005453-4057qib7 10544 4 syndrome syndrome NN cord-005453-4057qib7 10544 5 consisting consist VBG cord-005453-4057qib7 10544 6 of of IN cord-005453-4057qib7 10544 7 confusion confusion NN cord-005453-4057qib7 10544 8 and and CC cord-005453-4057qib7 10544 9 amnesia amnesia NN cord-005453-4057qib7 10544 10 developed develop VBN cord-005453-4057qib7 10544 11 in in IN cord-005453-4057qib7 10544 12 a a DT cord-005453-4057qib7 10544 13 49-years 49-years CD cord-005453-4057qib7 10544 14 - - HYPH cord-005453-4057qib7 10544 15 old old JJ cord-005453-4057qib7 10544 16 - - HYPH cord-005453-4057qib7 10544 17 patient patient NN cord-005453-4057qib7 10544 18 . . . cord-005453-4057qib7 10545 1 Brain Brain NNP cord-005453-4057qib7 10545 2 MRI MRI NNP cord-005453-4057qib7 10545 3 findings finding NNS cord-005453-4057qib7 10545 4 were be VBD cord-005453-4057qib7 10545 5 compatible compatible JJ cord-005453-4057qib7 10545 6 with with IN cord-005453-4057qib7 10545 7 a a DT cord-005453-4057qib7 10545 8 Wernicke Wernicke NNP cord-005453-4057qib7 10545 9 syndrome syndrome NN cord-005453-4057qib7 10545 10 , , , cord-005453-4057qib7 10545 11 but but CC cord-005453-4057qib7 10545 12 no no DT cord-005453-4057qib7 10545 13 improvement improvement NN cord-005453-4057qib7 10545 14 of of IN cord-005453-4057qib7 10545 15 neurologic neurologic JJ cord-005453-4057qib7 10545 16 symptoms symptom NNS cord-005453-4057qib7 10545 17 were be VBD cord-005453-4057qib7 10545 18 obtained obtain VBN cord-005453-4057qib7 10545 19 with with IN cord-005453-4057qib7 10545 20 thiamine thiamine NN cord-005453-4057qib7 10545 21 supplementation supplementation NN cord-005453-4057qib7 10545 22 . . . cord-005453-4057qib7 10546 1 CSF CSF NNP cord-005453-4057qib7 10546 2 analysis analysis NN cord-005453-4057qib7 10546 3 did do VBD cord-005453-4057qib7 10546 4 not not RB cord-005453-4057qib7 10546 5 revealed reveal VBN cord-005453-4057qib7 10546 6 HHV-6 HHV-6 NNP cord-005453-4057qib7 10546 7 DNA DNA NNP cord-005453-4057qib7 10546 8 , , , cord-005453-4057qib7 10546 9 which which WDT cord-005453-4057qib7 10546 10 was be VBD cord-005453-4057qib7 10546 11 detected detect VBN cord-005453-4057qib7 10546 12 at at IN cord-005453-4057qib7 10546 13 low low JJ cord-005453-4057qib7 10546 14 copies copy NNS cord-005453-4057qib7 10546 15 number number NN cord-005453-4057qib7 10546 16 on on IN cord-005453-4057qib7 10546 17 serum serum NN cord-005453-4057qib7 10546 18 analysis analysis NN cord-005453-4057qib7 10546 19 . . . cord-005453-4057qib7 10547 1 A a DT cord-005453-4057qib7 10547 2 second second JJ cord-005453-4057qib7 10547 3 brain brain NN cord-005453-4057qib7 10547 4 MRI MRI NNP cord-005453-4057qib7 10547 5 was be VBD cord-005453-4057qib7 10547 6 conclusive conclusive JJ cord-005453-4057qib7 10547 7 for for IN cord-005453-4057qib7 10547 8 limbic limbic NN cord-005453-4057qib7 10547 9 encephalitis encephalitis RB cord-005453-4057qib7 10547 10 , , , cord-005453-4057qib7 10547 11 so so IN cord-005453-4057qib7 10547 12 an an DT cord-005453-4057qib7 10547 13 antiviral antiviral JJ cord-005453-4057qib7 10547 14 therapy therapy NN cord-005453-4057qib7 10547 15 with with IN cord-005453-4057qib7 10547 16 Foscavir Foscavir NNP cord-005453-4057qib7 10547 17 was be VBD cord-005453-4057qib7 10547 18 started start VBN cord-005453-4057qib7 10547 19 and and CC cord-005453-4057qib7 10547 20 radiological radiological JJ cord-005453-4057qib7 10547 21 but but CC cord-005453-4057qib7 10547 22 not not RB cord-005453-4057qib7 10547 23 clinical clinical JJ cord-005453-4057qib7 10547 24 improvement improvement NN cord-005453-4057qib7 10547 25 was be VBD cord-005453-4057qib7 10547 26 noted note VBN cord-005453-4057qib7 10547 27 . . . cord-005453-4057qib7 10548 1 The the DT cord-005453-4057qib7 10548 2 patient patient NN cord-005453-4057qib7 10548 3 died die VBD cord-005453-4057qib7 10548 4 after after IN cord-005453-4057qib7 10548 5 few few JJ cord-005453-4057qib7 10548 6 days day NNS cord-005453-4057qib7 10548 7 . . . cord-005453-4057qib7 10549 1 4 4 LS cord-005453-4057qib7 10549 2 ) ) -RRB- cord-005453-4057qib7 10550 1 In in IN cord-005453-4057qib7 10550 2 the the DT cord-005453-4057qib7 10550 3 last last JJ cord-005453-4057qib7 10550 4 case case NN cord-005453-4057qib7 10550 5 we -PRON- PRP cord-005453-4057qib7 10550 6 present present VBP cord-005453-4057qib7 10550 7 a a DT cord-005453-4057qib7 10550 8 52-years 52-years CD cord-005453-4057qib7 10550 9 - - HYPH cord-005453-4057qib7 10550 10 old old JJ cord-005453-4057qib7 10550 11 patient patient NN cord-005453-4057qib7 10550 12 who who WP cord-005453-4057qib7 10550 13 developed develop VBD cord-005453-4057qib7 10550 14 a a DT cord-005453-4057qib7 10550 15 clinical clinical JJ cord-005453-4057qib7 10550 16 picture picture NN cord-005453-4057qib7 10550 17 of of IN cord-005453-4057qib7 10550 18 encephalopathy encephalopathy NN cord-005453-4057qib7 10550 19 ( ( -LRB- cord-005453-4057qib7 10550 20 i.e. i.e. FW cord-005453-4057qib7 10550 21 amnesia amnesia NN cord-005453-4057qib7 10550 22 , , , cord-005453-4057qib7 10550 23 ataxia ataxia NN cord-005453-4057qib7 10550 24 , , , cord-005453-4057qib7 10550 25 drowsiness drowsiness NN cord-005453-4057qib7 10550 26 , , , cord-005453-4057qib7 10550 27 weakness weakness NN cord-005453-4057qib7 10550 28 , , , cord-005453-4057qib7 10550 29 depression depression NN cord-005453-4057qib7 10550 30 ) ) -RRB- cord-005453-4057qib7 10550 31 with with IN cord-005453-4057qib7 10550 32 rapid rapid JJ cord-005453-4057qib7 10550 33 progression progression NN cord-005453-4057qib7 10550 34 to to IN cord-005453-4057qib7 10550 35 coma coma NN cord-005453-4057qib7 10550 36 after after IN cord-005453-4057qib7 10550 37 seventy seventy CD cord-005453-4057qib7 10550 38 - - HYPH cord-005453-4057qib7 10550 39 eight eight CD cord-005453-4057qib7 10550 40 days day NNS cord-005453-4057qib7 10550 41 from from IN cord-005453-4057qib7 10550 42 HSCT HSCT NNP cord-005453-4057qib7 10550 43 . . . cord-005453-4057qib7 10551 1 A a DT cord-005453-4057qib7 10551 2 brain brain NN cord-005453-4057qib7 10551 3 MRI MRI NNP cord-005453-4057qib7 10551 4 showed show VBD cord-005453-4057qib7 10551 5 a a DT cord-005453-4057qib7 10551 6 slight slight JJ cord-005453-4057qib7 10551 7 contrast contrast NN cord-005453-4057qib7 10551 8 enhancement enhancement NN cord-005453-4057qib7 10551 9 in in IN cord-005453-4057qib7 10551 10 parietal parietal JJ cord-005453-4057qib7 10551 11 - - HYPH cord-005453-4057qib7 10551 12 occipital occipital JJ cord-005453-4057qib7 10551 13 regions region NNS cord-005453-4057qib7 10551 14 . . . cord-005453-4057qib7 10552 1 During during IN cord-005453-4057qib7 10552 2 the the DT cord-005453-4057qib7 10552 3 recovery recovery NN cord-005453-4057qib7 10552 4 phase phase NN cord-005453-4057qib7 10552 5 from from IN cord-005453-4057qib7 10552 6 conditioning conditioning NN cord-005453-4057qib7 10552 7 - - HYPH cord-005453-4057qib7 10552 8 induced induce VBN cord-005453-4057qib7 10552 9 cytopenia cytopenia NNP cord-005453-4057qib7 10552 10 , , , cord-005453-4057qib7 10552 11 an an DT cord-005453-4057qib7 10552 12 increasing increase VBG cord-005453-4057qib7 10552 13 in in IN cord-005453-4057qib7 10552 14 serum serum NN cord-005453-4057qib7 10552 15 HHV-6 HHV-6 NNP cord-005453-4057qib7 10552 16 DNA DNA NNP cord-005453-4057qib7 10552 17 was be VBD cord-005453-4057qib7 10552 18 detected detect VBN cord-005453-4057qib7 10552 19 . . . cord-005453-4057qib7 10553 1 Searching search VBG cord-005453-4057qib7 10553 2 for for IN cord-005453-4057qib7 10553 3 HHV-6 HHV-6 NNP cord-005453-4057qib7 10553 4 DNA DNA NNP cord-005453-4057qib7 10553 5 on on IN cord-005453-4057qib7 10553 6 donor donor NN cord-005453-4057qib7 10553 7 's 's POS cord-005453-4057qib7 10553 8 follicles follicle NNS cord-005453-4057qib7 10553 9 showed show VBD cord-005453-4057qib7 10553 10 a a DT cord-005453-4057qib7 10553 11 chromosomally chromosomally RB cord-005453-4057qib7 10553 12 integrated integrate VBN cord-005453-4057qib7 10553 13 HHV-6 HHV-6 NNP cord-005453-4057qib7 10553 14 ( ( -LRB- cord-005453-4057qib7 10553 15 ciHHV-6 ciHHV-6 NNP cord-005453-4057qib7 10553 16 ) ) -RRB- cord-005453-4057qib7 10553 17 . . . cord-005453-4057qib7 10554 1 Cyclosporin Cyclosporin NNP cord-005453-4057qib7 10554 2 A a DT cord-005453-4057qib7 10554 3 ( ( -LRB- cord-005453-4057qib7 10554 4 CsA csa NN cord-005453-4057qib7 10554 5 ) ) -RRB- cord-005453-4057qib7 10554 6 was be VBD cord-005453-4057qib7 10554 7 interrupted interrupt VBN cord-005453-4057qib7 10554 8 and and CC cord-005453-4057qib7 10554 9 neurological neurological JJ cord-005453-4057qib7 10554 10 improvement improvement NN cord-005453-4057qib7 10554 11 was be VBD cord-005453-4057qib7 10554 12 observed observe VBN cord-005453-4057qib7 10554 13 in in IN cord-005453-4057qib7 10554 14 the the DT cord-005453-4057qib7 10554 15 following follow VBG cord-005453-4057qib7 10554 16 hours hour NNS cord-005453-4057qib7 10554 17 : : : cord-005453-4057qib7 10554 18 a a DT cord-005453-4057qib7 10554 19 diagnosis diagnosis NN cord-005453-4057qib7 10554 20 of of IN cord-005453-4057qib7 10554 21 PRES PRES NNP cord-005453-4057qib7 10554 22 was be VBD cord-005453-4057qib7 10554 23 made make VBN cord-005453-4057qib7 10554 24 . . . cord-005453-4057qib7 10555 1 Conclusions conclusion NNS cord-005453-4057qib7 10555 2 : : : cord-005453-4057qib7 10556 1 HHV-6 HHV-6 NNP cord-005453-4057qib7 10556 2 encephalitis encephalitis RB cord-005453-4057qib7 10556 3 should should MD cord-005453-4057qib7 10556 4 be be VB cord-005453-4057qib7 10556 5 suspected suspect VBN cord-005453-4057qib7 10556 6 in in IN cord-005453-4057qib7 10556 7 transplanted transplanted JJ cord-005453-4057qib7 10556 8 patients patient NNS cord-005453-4057qib7 10556 9 with with IN cord-005453-4057qib7 10556 10 a a DT cord-005453-4057qib7 10556 11 clinical clinical JJ cord-005453-4057qib7 10556 12 syndrome syndrome NN cord-005453-4057qib7 10556 13 of of IN cord-005453-4057qib7 10556 14 encephalopathy encephalopathy NN cord-005453-4057qib7 10556 15 . . . cord-005453-4057qib7 10557 1 PCR PCR NNP cord-005453-4057qib7 10557 2 detection detection NN cord-005453-4057qib7 10557 3 of of IN cord-005453-4057qib7 10557 4 HHV-6 HHV-6 NNP cord-005453-4057qib7 10557 5 DNA DNA NNP cord-005453-4057qib7 10557 6 in in IN cord-005453-4057qib7 10557 7 CSF csf NN cord-005453-4057qib7 10557 8 associated associate VBN cord-005453-4057qib7 10557 9 with with IN cord-005453-4057qib7 10557 10 either either DT cord-005453-4057qib7 10557 11 typical typical JJ cord-005453-4057qib7 10557 12 brain brain NN cord-005453-4057qib7 10557 13 MRI MRI NNP cord-005453-4057qib7 10557 14 abnormalities abnormality NNS cord-005453-4057qib7 10557 15 or or CC cord-005453-4057qib7 10557 16 a a DT cord-005453-4057qib7 10557 17 clinical clinical JJ cord-005453-4057qib7 10557 18 diagnosis diagnosis NN cord-005453-4057qib7 10557 19 of of IN cord-005453-4057qib7 10557 20 nonspecific nonspecific JJ cord-005453-4057qib7 10557 21 encephalopathy encephalopathy NN cord-005453-4057qib7 10557 22 must must MD cord-005453-4057qib7 10557 23 lead lead VB cord-005453-4057qib7 10557 24 to to IN cord-005453-4057qib7 10557 25 the the DT cord-005453-4057qib7 10557 26 urgent urgent JJ cord-005453-4057qib7 10557 27 initiation initiation NN cord-005453-4057qib7 10557 28 of of IN cord-005453-4057qib7 10557 29 systemic systemic JJ cord-005453-4057qib7 10557 30 antiviral antiviral JJ cord-005453-4057qib7 10557 31 treatment treatment NN cord-005453-4057qib7 10557 32 . . . cord-005453-4057qib7 10558 1 If if IN cord-005453-4057qib7 10558 2 an an DT cord-005453-4057qib7 10558 3 increase increase NN cord-005453-4057qib7 10558 4 of of IN cord-005453-4057qib7 10558 5 both both DT cord-005453-4057qib7 10558 6 serum serum NN cord-005453-4057qib7 10558 7 HHV-6 HHV-6 NNP cord-005453-4057qib7 10558 8 DNA DNA NNP cord-005453-4057qib7 10558 9 and and CC cord-005453-4057qib7 10558 10 WBC WBC NNP cord-005453-4057qib7 10558 11 is be VBZ cord-005453-4057qib7 10558 12 detected detect VBN cord-005453-4057qib7 10558 13 , , , cord-005453-4057qib7 10558 14 a a DT cord-005453-4057qib7 10558 15 ciHHV-6 ciHHV-6 NNP cord-005453-4057qib7 10558 16 should should MD cord-005453-4057qib7 10558 17 be be VB cord-005453-4057qib7 10558 18 confirmed confirm VBN cord-005453-4057qib7 10558 19 . . . cord-005453-4057qib7 10559 1 PRES PRES NNP cord-005453-4057qib7 10559 2 is be VBZ cord-005453-4057qib7 10559 3 an an DT cord-005453-4057qib7 10559 4 important important JJ cord-005453-4057qib7 10559 5 differential differential JJ cord-005453-4057qib7 10559 6 diagnosis diagnosis NN cord-005453-4057qib7 10559 7 in in IN cord-005453-4057qib7 10559 8 transplanted transplanted JJ cord-005453-4057qib7 10559 9 patients patient NNS cord-005453-4057qib7 10559 10 which which WDT cord-005453-4057qib7 10559 11 developed develop VBD cord-005453-4057qib7 10559 12 an an DT cord-005453-4057qib7 10559 13 encephalitic encephalitic JJ cord-005453-4057qib7 10559 14 syndrome syndrome NN cord-005453-4057qib7 10559 15 . . . cord-005453-4057qib7 10560 1 Disclosure disclosure NN cord-005453-4057qib7 10560 2 : : : cord-005453-4057qib7 10560 3 Nothing nothing NN cord-005453-4057qib7 10560 4 to to TO cord-005453-4057qib7 10560 5 declare declare VB cord-005453-4057qib7 10560 6 Background background NN cord-005453-4057qib7 10560 7 : : : cord-005453-4057qib7 10561 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 10561 2 ( ( -LRB- cord-005453-4057qib7 10561 3 CMV CMV NNP cord-005453-4057qib7 10561 4 ) ) -RRB- cord-005453-4057qib7 10561 5 infection infection NN cord-005453-4057qib7 10561 6 is be VBZ cord-005453-4057qib7 10561 7 a a DT cord-005453-4057qib7 10561 8 major major JJ cord-005453-4057qib7 10561 9 cause cause NN cord-005453-4057qib7 10561 10 of of IN cord-005453-4057qib7 10561 11 morbidity morbidity NN cord-005453-4057qib7 10561 12 and and CC cord-005453-4057qib7 10561 13 mortality mortality NN cord-005453-4057qib7 10561 14 after after IN cord-005453-4057qib7 10561 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 10561 16 stem stem NN cord-005453-4057qib7 10561 17 cell cell NN cord-005453-4057qib7 10561 18 transplantation transplantation NN cord-005453-4057qib7 10561 19 ( ( -LRB- cord-005453-4057qib7 10561 20 HSCT HSCT NNP cord-005453-4057qib7 10561 21 ) ) -RRB- cord-005453-4057qib7 10561 22 . . . cord-005453-4057qib7 10562 1 It -PRON- PRP cord-005453-4057qib7 10562 2 causes cause VBZ cord-005453-4057qib7 10562 3 end end NN cord-005453-4057qib7 10562 4 - - HYPH cord-005453-4057qib7 10562 5 organ organ NN cord-005453-4057qib7 10562 6 disease disease NN cord-005453-4057qib7 10562 7 , , , cord-005453-4057qib7 10562 8 multi multi JJ cord-005453-4057qib7 10562 9 - - JJ cord-005453-4057qib7 10562 10 organ organ JJ cord-005453-4057qib7 10562 11 dysfunction dysfunction NN cord-005453-4057qib7 10562 12 syndrome syndrome NN cord-005453-4057qib7 10562 13 , , , cord-005453-4057qib7 10562 14 graft graft NN cord-005453-4057qib7 10562 15 failure failure NN cord-005453-4057qib7 10562 16 , , , cord-005453-4057qib7 10562 17 increased increase VBN cord-005453-4057qib7 10562 18 susceptibility susceptibility NN cord-005453-4057qib7 10562 19 to to IN cord-005453-4057qib7 10562 20 infections infection NNS cord-005453-4057qib7 10562 21 and and CC cord-005453-4057qib7 10562 22 GVHD GVHD NNP cord-005453-4057qib7 10562 23 . . . cord-005453-4057qib7 10563 1 Greatest great JJS cord-005453-4057qib7 10563 2 risk risk NN cord-005453-4057qib7 10563 3 of of IN cord-005453-4057qib7 10563 4 CMV CMV NNP cord-005453-4057qib7 10563 5 infection infection NN cord-005453-4057qib7 10563 6 in in IN cord-005453-4057qib7 10563 7 a a DT cord-005453-4057qib7 10563 8 seropositive seropositive JJ cord-005453-4057qib7 10563 9 host host NN cord-005453-4057qib7 10563 10 is be VBZ cord-005453-4057qib7 10563 11 the the DT cord-005453-4057qib7 10563 12 reactivation reactivation NN cord-005453-4057qib7 10563 13 of of IN cord-005453-4057qib7 10563 14 latent latent JJ cord-005453-4057qib7 10563 15 virus virus NN cord-005453-4057qib7 10563 16 . . . cord-005453-4057qib7 10564 1 Methods method NNS cord-005453-4057qib7 10564 2 : : : cord-005453-4057qib7 10565 1 A a DT cord-005453-4057qib7 10565 2 prospective prospective JJ cord-005453-4057qib7 10565 3 descriptive descriptive JJ cord-005453-4057qib7 10565 4 study study NN cord-005453-4057qib7 10565 5 performed perform VBN cord-005453-4057qib7 10565 6 at at IN cord-005453-4057qib7 10565 7 Armed Armed NNP cord-005453-4057qib7 10565 8 Forces Forces NNPS cord-005453-4057qib7 10565 9 Bone Bone NNP cord-005453-4057qib7 10565 10 Marrow Marrow NNP cord-005453-4057qib7 10565 11 Transplant Transplant NNP cord-005453-4057qib7 10565 12 Centre Centre NNP cord-005453-4057qib7 10565 13 , , , cord-005453-4057qib7 10565 14 Rawalpindi Rawalpindi NNP cord-005453-4057qib7 10565 15 , , , cord-005453-4057qib7 10565 16 Pakistan Pakistan NNP cord-005453-4057qib7 10565 17 from from IN cord-005453-4057qib7 10565 18 Dec Dec NNP cord-005453-4057qib7 10565 19 2016 2016 CD cord-005453-4057qib7 10565 20 to to IN cord-005453-4057qib7 10565 21 Sep Sep NNP cord-005453-4057qib7 10565 22 2018 2018 CD cord-005453-4057qib7 10565 23 . . . cord-005453-4057qib7 10566 1 Hundred hundred CD cord-005453-4057qib7 10566 2 consecutive consecutive JJ cord-005453-4057qib7 10566 3 patients patient NNS cord-005453-4057qib7 10566 4 who who WP cord-005453-4057qib7 10566 5 underwent undergo VBD cord-005453-4057qib7 10566 6 HSCT HSCT NNP cord-005453-4057qib7 10566 7 were be VBD cord-005453-4057qib7 10566 8 followed follow VBN cord-005453-4057qib7 10566 9 with with IN cord-005453-4057qib7 10566 10 weekly weekly JJ cord-005453-4057qib7 10566 11 CMV CMV NNP cord-005453-4057qib7 10566 12 DNA DNA NNP cord-005453-4057qib7 10566 13 quantitative quantitative JJ cord-005453-4057qib7 10566 14 PCR pcr NN cord-005453-4057qib7 10566 15 from from IN cord-005453-4057qib7 10566 16 engraftment engraftment NN cord-005453-4057qib7 10566 17 till till IN cord-005453-4057qib7 10566 18 day day NN cord-005453-4057qib7 10566 19 100 100 CD cord-005453-4057qib7 10566 20 for for IN cord-005453-4057qib7 10566 21 CMV CMV NNP cord-005453-4057qib7 10566 22 reactivation reactivation NN cord-005453-4057qib7 10566 23 . . . cord-005453-4057qib7 10567 1 Patients patient NNS cord-005453-4057qib7 10567 2 in in IN cord-005453-4057qib7 10567 3 whom whom WP cord-005453-4057qib7 10567 4 CMV CMV NNP cord-005453-4057qib7 10567 5 PCR PCR NNP cord-005453-4057qib7 10567 6 showed show VBD cord-005453-4057qib7 10567 7 more more JJR cord-005453-4057qib7 10567 8 than than IN cord-005453-4057qib7 10567 9 2000 2000 CD cord-005453-4057qib7 10567 10 copies copy NNS cord-005453-4057qib7 10567 11 / / SYM cord-005453-4057qib7 10567 12 ml ml NNS cord-005453-4057qib7 10567 13 were be VBD cord-005453-4057qib7 10567 14 treated treat VBN cord-005453-4057qib7 10567 15 with with IN cord-005453-4057qib7 10567 16 antiviral antiviral JJ cord-005453-4057qib7 10567 17 therapy therapy NN cord-005453-4057qib7 10567 18 . . . cord-005453-4057qib7 10568 1 Factors factor NNS cord-005453-4057qib7 10568 2 associated associate VBN cord-005453-4057qib7 10568 3 with with IN cord-005453-4057qib7 10568 4 CMV CMV NNP cord-005453-4057qib7 10568 5 reactivation reactivation NN cord-005453-4057qib7 10568 6 , , , cord-005453-4057qib7 10568 7 outcome outcome NN cord-005453-4057qib7 10568 8 of of IN cord-005453-4057qib7 10568 9 antiviral antiviral JJ cord-005453-4057qib7 10568 10 therapy therapy NN cord-005453-4057qib7 10568 11 and and CC cord-005453-4057qib7 10568 12 effect effect NN cord-005453-4057qib7 10568 13 of of IN cord-005453-4057qib7 10568 14 CMV CMV NNP cord-005453-4057qib7 10568 15 on on IN cord-005453-4057qib7 10568 16 transplant transplant NN cord-005453-4057qib7 10568 17 outcome outcome NN cord-005453-4057qib7 10568 18 is be VBZ cord-005453-4057qib7 10568 19 studied study VBN cord-005453-4057qib7 10568 20 . . . cord-005453-4057qib7 10569 1 Results result NNS cord-005453-4057qib7 10569 2 : : : cord-005453-4057qib7 10570 1 Out out IN cord-005453-4057qib7 10570 2 of of IN cord-005453-4057qib7 10570 3 100 100 CD cord-005453-4057qib7 10570 4 cases case NNS cord-005453-4057qib7 10570 5 , , , cord-005453-4057qib7 10570 6 82 82 CD cord-005453-4057qib7 10570 7 were be VBD cord-005453-4057qib7 10570 8 HLA HLA NNP cord-005453-4057qib7 10570 9 matched match VBN cord-005453-4057qib7 10570 10 siblings sibling NNS cord-005453-4057qib7 10570 11 , , , cord-005453-4057qib7 10570 12 15 15 CD cord-005453-4057qib7 10570 13 were be VBD cord-005453-4057qib7 10570 14 matched match VBN cord-005453-4057qib7 10571 1 family family NN cord-005453-4057qib7 10571 2 donors donor NNS cord-005453-4057qib7 10571 3 and and CC cord-005453-4057qib7 10571 4 3 3 CD cord-005453-4057qib7 10571 5 were be VBD cord-005453-4057qib7 10571 6 haploidentical haploidentical JJ cord-005453-4057qib7 10571 7 transplants transplant NNS cord-005453-4057qib7 10572 1 There there EX cord-005453-4057qib7 10572 2 were be VBD cord-005453-4057qib7 10572 3 66 66 CD cord-005453-4057qib7 10572 4 males male NNS cord-005453-4057qib7 10572 5 and and CC cord-005453-4057qib7 10572 6 34 34 CD cord-005453-4057qib7 10572 7 females female NNS cord-005453-4057qib7 10572 8 . . . cord-005453-4057qib7 10573 1 Mean mean JJ cord-005453-4057qib7 10573 2 age age NN cord-005453-4057qib7 10573 3 was be VBD cord-005453-4057qib7 10573 4 11.9 11.9 CD cord-005453-4057qib7 10573 5 ±8.9 ±8.9 JJ cord-005453-4057qib7 10573 6 years year NNS cord-005453-4057qib7 10573 7 . . . cord-005453-4057qib7 10574 1 Fourty fourty CD cord-005453-4057qib7 10574 2 - - HYPH cord-005453-4057qib7 10574 3 two two CD cord-005453-4057qib7 10574 4 transplants transplant NNS cord-005453-4057qib7 10574 5 were be VBD cord-005453-4057qib7 10574 6 done do VBN cord-005453-4057qib7 10574 7 in in IN cord-005453-4057qib7 10574 8 thalassemia thalassemia NN cord-005453-4057qib7 10574 9 , , , cord-005453-4057qib7 10574 10 35 35 CD cord-005453-4057qib7 10574 11 in in IN cord-005453-4057qib7 10574 12 aplasia aplasia NNP cord-005453-4057qib7 10574 13 , , , cord-005453-4057qib7 10574 14 09 09 CD cord-005453-4057qib7 10574 15 in in IN cord-005453-4057qib7 10574 16 leukemias leukemia NNS cord-005453-4057qib7 10574 17 and and CC cord-005453-4057qib7 10574 18 14 14 CD cord-005453-4057qib7 10574 19 in in IN cord-005453-4057qib7 10574 20 other other JJ cord-005453-4057qib7 10574 21 hematological hematological JJ cord-005453-4057qib7 10574 22 disorders disorder NNS cord-005453-4057qib7 10574 23 and and CC cord-005453-4057qib7 10574 24 immune immune JJ cord-005453-4057qib7 10574 25 deficiencies deficiency NNS cord-005453-4057qib7 10574 26 . . . cord-005453-4057qib7 10575 1 Ninety ninety CD cord-005453-4057qib7 10575 2 - - HYPH cord-005453-4057qib7 10575 3 eight eight CD cord-005453-4057qib7 10575 4 recipients recipient NNS cord-005453-4057qib7 10575 5 and and CC cord-005453-4057qib7 10575 6 all all PDT cord-005453-4057qib7 10575 7 the the DT cord-005453-4057qib7 10575 8 donors donor NNS cord-005453-4057qib7 10575 9 were be VBD cord-005453-4057qib7 10575 10 CMV CMV NNP cord-005453-4057qib7 10575 11 seropositive seropositive JJ cord-005453-4057qib7 10575 12 before before IN cord-005453-4057qib7 10575 13 HSCT HSCT NNP cord-005453-4057qib7 10575 14 . . . cord-005453-4057qib7 10576 1 CMV CMV NNP cord-005453-4057qib7 10576 2 reactivation reactivation NN cord-005453-4057qib7 10576 3 was be VBD cord-005453-4057qib7 10576 4 seen see VBN cord-005453-4057qib7 10576 5 in in IN cord-005453-4057qib7 10576 6 81 81 CD cord-005453-4057qib7 10576 7 patients patient NNS cord-005453-4057qib7 10576 8 and and CC cord-005453-4057qib7 10576 9 42 42 CD cord-005453-4057qib7 10576 10 of of IN cord-005453-4057qib7 10576 11 them -PRON- PRP cord-005453-4057qib7 10576 12 had have VBD cord-005453-4057qib7 10576 13 CMV CMV NNP cord-005453-4057qib7 10576 14 viral viral JJ cord-005453-4057qib7 10576 15 load load NN cord-005453-4057qib7 10577 1 more more JJR cord-005453-4057qib7 10577 2 than than IN cord-005453-4057qib7 10577 3 2000 2000 CD cord-005453-4057qib7 10577 4 copies copy NNS cord-005453-4057qib7 10577 5 / / SYM cord-005453-4057qib7 10577 6 ml ml NN cord-005453-4057qib7 10577 7 and and CC cord-005453-4057qib7 10577 8 39 39 CD cord-005453-4057qib7 10577 9 patients patient NNS cord-005453-4057qib7 10577 10 had have VBD cord-005453-4057qib7 10577 11 CMV CMV NNP cord-005453-4057qib7 10577 12 viral viral JJ cord-005453-4057qib7 10577 13 load load NN cord-005453-4057qib7 10578 1 less less JJR cord-005453-4057qib7 10578 2 than than IN cord-005453-4057qib7 10578 3 2000 2000 CD cord-005453-4057qib7 10578 4 copies copy NNS cord-005453-4057qib7 10578 5 / / SYM cord-005453-4057qib7 10578 6 ml ml NN cord-005453-4057qib7 10578 7 . . . cord-005453-4057qib7 10579 1 Nineteen nineteen CD cord-005453-4057qib7 10579 2 patients patient NNS cord-005453-4057qib7 10579 3 had have VBD cord-005453-4057qib7 10579 4 no no DT cord-005453-4057qib7 10579 5 CMV CMV NNP cord-005453-4057qib7 10579 6 reactivation reactivation NN cord-005453-4057qib7 10579 7 . . . cord-005453-4057qib7 10580 1 Mean mean JJ cord-005453-4057qib7 10580 2 time time NN cord-005453-4057qib7 10580 3 to to IN cord-005453-4057qib7 10580 4 reactivation reactivation NN cord-005453-4057qib7 10580 5 since since IN cord-005453-4057qib7 10580 6 transplant transplant NN cord-005453-4057qib7 10580 7 was be VBD cord-005453-4057qib7 10580 8 36±19 36±19 NNP cord-005453-4057qib7 10580 9 days day NNS cord-005453-4057qib7 10580 10 . . . cord-005453-4057qib7 10581 1 Valganciclovir Valganciclovir NNP cord-005453-4057qib7 10581 2 was be VBD cord-005453-4057qib7 10581 3 given give VBN cord-005453-4057qib7 10581 4 in in IN cord-005453-4057qib7 10581 5 36 36 CD cord-005453-4057qib7 10581 6 patients patient NNS cord-005453-4057qib7 10581 7 due due JJ cord-005453-4057qib7 10581 8 to to IN cord-005453-4057qib7 10581 9 ease ease NN cord-005453-4057qib7 10581 10 of of IN cord-005453-4057qib7 10581 11 administration administration NN cord-005453-4057qib7 10581 12 and and CC cord-005453-4057qib7 10581 13 six six CD cord-005453-4057qib7 10581 14 patients patient NNS cord-005453-4057qib7 10581 15 were be VBD cord-005453-4057qib7 10581 16 treated treat VBN cord-005453-4057qib7 10581 17 with with IN cord-005453-4057qib7 10581 18 ganciclovir ganciclovir NNS cord-005453-4057qib7 10581 19 during during IN cord-005453-4057qib7 10581 20 their -PRON- PRP$ cord-005453-4057qib7 10581 21 hospital hospital NN cord-005453-4057qib7 10581 22 stay stay NN cord-005453-4057qib7 10581 23 . . . cord-005453-4057qib7 10582 1 Only only RB cord-005453-4057qib7 10582 2 one one CD cord-005453-4057qib7 10582 3 patient patient NN cord-005453-4057qib7 10582 4 had have VBD cord-005453-4057qib7 10582 5 resistant resistant JJ cord-005453-4057qib7 10582 6 disease disease NN cord-005453-4057qib7 10582 7 . . . cord-005453-4057qib7 10583 1 Mean mean JJ cord-005453-4057qib7 10583 2 time time NN cord-005453-4057qib7 10583 3 to to TO cord-005453-4057qib7 10583 4 clear clear JJ cord-005453-4057qib7 10583 5 viremia viremia NN cord-005453-4057qib7 10583 6 was be VBD cord-005453-4057qib7 10583 7 20±12.8 20±12.8 CD cord-005453-4057qib7 10583 8 days day NNS cord-005453-4057qib7 10583 9 . . . cord-005453-4057qib7 10584 1 The the DT cord-005453-4057qib7 10584 2 patients patient NNS cord-005453-4057qib7 10584 3 having have VBG cord-005453-4057qib7 10584 4 viral viral JJ cord-005453-4057qib7 10584 5 load load NN cord-005453-4057qib7 10584 6 less less JJR cord-005453-4057qib7 10584 7 than than IN cord-005453-4057qib7 10584 8 2000 2000 CD cord-005453-4057qib7 10584 9 copies copy NNS cord-005453-4057qib7 10584 10 / / SYM cord-005453-4057qib7 10584 11 ml ml NNS cord-005453-4057qib7 10584 12 , , , cord-005453-4057qib7 10584 13 subsequently subsequently RB cord-005453-4057qib7 10584 14 cleared clear VBD cord-005453-4057qib7 10584 15 CMV CMV NNP cord-005453-4057qib7 10584 16 without without IN cord-005453-4057qib7 10584 17 any any DT cord-005453-4057qib7 10584 18 treatment treatment NN cord-005453-4057qib7 10584 19 . . . cord-005453-4057qib7 10585 1 Antiviral antiviral JJ cord-005453-4057qib7 10585 2 agents agent NNS cord-005453-4057qib7 10585 3 ; ; : cord-005453-4057qib7 10585 4 ganciclovir ganciclovir NNP cord-005453-4057qib7 10585 5 and and CC cord-005453-4057qib7 10585 6 valganciclovir valganciclovir NNP cord-005453-4057qib7 10585 7 were be VBD cord-005453-4057qib7 10585 8 equally equally RB cord-005453-4057qib7 10585 9 effective effective JJ cord-005453-4057qib7 10585 10 for for IN cord-005453-4057qib7 10585 11 treating treat VBG cord-005453-4057qib7 10585 12 CMV CMV NNP cord-005453-4057qib7 10585 13 infection infection NN cord-005453-4057qib7 10585 14 with with IN cord-005453-4057qib7 10585 15 99 99 CD cord-005453-4057qib7 10585 16 % % NN cord-005453-4057qib7 10585 17 efficacy efficacy NN cord-005453-4057qib7 10585 18 , , , cord-005453-4057qib7 10585 19 however however RB cord-005453-4057qib7 10585 20 , , , cord-005453-4057qib7 10585 21 more more RBR cord-005453-4057qib7 10585 22 adverse adverse JJ cord-005453-4057qib7 10585 23 effects effect NNS cord-005453-4057qib7 10585 24 were be VBD cord-005453-4057qib7 10585 25 seen see VBN cord-005453-4057qib7 10585 26 with with IN cord-005453-4057qib7 10585 27 ganciclovir ganciclovir NNS cord-005453-4057qib7 10585 28 . . . cord-005453-4057qib7 10586 1 Myelosuppression Myelosuppression NNP cord-005453-4057qib7 10586 2 I I NNP cord-005453-4057qib7 10586 3 - - HYPH cord-005453-4057qib7 10586 4 III III NNP cord-005453-4057qib7 10586 5 was be VBD cord-005453-4057qib7 10586 6 seen see VBN cord-005453-4057qib7 10586 7 in in IN cord-005453-4057qib7 10586 8 24 24 CD cord-005453-4057qib7 10586 9 % % NN cord-005453-4057qib7 10586 10 patients patient NNS cord-005453-4057qib7 10586 11 treated treat VBN cord-005453-4057qib7 10586 12 with with IN cord-005453-4057qib7 10586 13 valganciclovir valganciclovir NNS cord-005453-4057qib7 10586 14 and and CC cord-005453-4057qib7 10586 15 in in IN cord-005453-4057qib7 10586 16 46 46 CD cord-005453-4057qib7 10586 17 % % NN cord-005453-4057qib7 10586 18 treated treat VBN cord-005453-4057qib7 10586 19 with with IN cord-005453-4057qib7 10586 20 valganciclovir valganciclovir NNP cord-005453-4057qib7 10586 21 . . . cord-005453-4057qib7 10587 1 Renal renal JJ cord-005453-4057qib7 10587 2 impairment impairment NN cord-005453-4057qib7 10588 1 I -PRON- PRP cord-005453-4057qib7 10588 2 - - HYPH cord-005453-4057qib7 10588 3 II II NNP cord-005453-4057qib7 10588 4 was be VBD cord-005453-4057qib7 10588 5 seen see VBN cord-005453-4057qib7 10588 6 in in IN cord-005453-4057qib7 10588 7 14 14 CD cord-005453-4057qib7 10588 8 % % NN cord-005453-4057qib7 10588 9 of of IN cord-005453-4057qib7 10588 10 valganciclovir valganciclovir NNS cord-005453-4057qib7 10588 11 and and CC cord-005453-4057qib7 10588 12 20 20 CD cord-005453-4057qib7 10588 13 % % NN cord-005453-4057qib7 10588 14 of of IN cord-005453-4057qib7 10588 15 ganciclovir ganciclovir NNS cord-005453-4057qib7 10588 16 treated treat VBN cord-005453-4057qib7 10588 17 patients patient NNS cord-005453-4057qib7 10588 18 . . . cord-005453-4057qib7 10589 1 Steroid Steroid NNP cord-005453-4057qib7 10589 2 administration administration NN cord-005453-4057qib7 10589 3 was be VBD cord-005453-4057qib7 10589 4 strongly strongly RB cord-005453-4057qib7 10589 5 associated associate VBN cord-005453-4057qib7 10589 6 with with IN cord-005453-4057qib7 10589 7 CMV CMV NNP cord-005453-4057qib7 10589 8 reactivation reactivation NN cord-005453-4057qib7 10589 9 ( ( -LRB- cord-005453-4057qib7 10589 10 p p NN cord-005453-4057qib7 10589 11 = = SYM cord-005453-4057qib7 10589 12 0.003 0.003 CD cord-005453-4057qib7 10589 13 ) ) -RRB- cord-005453-4057qib7 10589 14 . . . cord-005453-4057qib7 10590 1 No no DT cord-005453-4057qib7 10590 2 statistically statistically RB cord-005453-4057qib7 10590 3 significant significant JJ cord-005453-4057qib7 10590 4 association association NN cord-005453-4057qib7 10590 5 was be VBD cord-005453-4057qib7 10590 6 found find VBN cord-005453-4057qib7 10590 7 with with IN cord-005453-4057qib7 10590 8 the the DT cord-005453-4057qib7 10590 9 use use NN cord-005453-4057qib7 10590 10 of of IN cord-005453-4057qib7 10590 11 ATG ATG NNP cord-005453-4057qib7 10590 12 , , , cord-005453-4057qib7 10590 13 GVHD GVHD NNP cord-005453-4057qib7 10590 14 , , , cord-005453-4057qib7 10590 15 underlying underlie VBG cord-005453-4057qib7 10590 16 disease disease NN cord-005453-4057qib7 10590 17 , , , cord-005453-4057qib7 10590 18 ABO ABO NNP cord-005453-4057qib7 10590 19 or or CC cord-005453-4057qib7 10590 20 gender gender NN cord-005453-4057qib7 10590 21 mismatch mismatch NN cord-005453-4057qib7 10590 22 . . . cord-005453-4057qib7 10591 1 OS OS NNP cord-005453-4057qib7 10591 2 was be VBD cord-005453-4057qib7 10591 3 81.0 81.0 CD cord-005453-4057qib7 10591 4 % % NN cord-005453-4057qib7 10591 5 and and CC cord-005453-4057qib7 10591 6 93.1 93.1 CD cord-005453-4057qib7 10591 7 % % NN cord-005453-4057qib7 10591 8 in in IN cord-005453-4057qib7 10591 9 with with IN cord-005453-4057qib7 10591 10 and and CC cord-005453-4057qib7 10591 11 without without IN cord-005453-4057qib7 10591 12 CMV CMV NNP cord-005453-4057qib7 10591 13 Reactivation Reactivation NNP cord-005453-4057qib7 10591 14 ( ( -LRB- cord-005453-4057qib7 10591 15 p=0.1 p=0.1 NNP cord-005453-4057qib7 10591 16 ) ) -RRB- cord-005453-4057qib7 10591 17 and and CC cord-005453-4057qib7 10591 18 DFS DFS NNP cord-005453-4057qib7 10591 19 was be VBD cord-005453-4057qib7 10591 20 83.3 83.3 CD cord-005453-4057qib7 10591 21 % % NN cord-005453-4057qib7 10591 22 and and CC cord-005453-4057qib7 10591 23 96.6 96.6 CD cord-005453-4057qib7 10591 24 % % NN cord-005453-4057qib7 10591 25 in in IN cord-005453-4057qib7 10591 26 with with IN cord-005453-4057qib7 10591 27 and and CC cord-005453-4057qib7 10591 28 without without IN cord-005453-4057qib7 10592 1 CMV CMV NNP cord-005453-4057qib7 10592 2 Reactivation Reactivation NNP cord-005453-4057qib7 10592 3 ( ( -LRB- cord-005453-4057qib7 10592 4 p=0.06 p=0.06 NNP cord-005453-4057qib7 10592 5 ) ) -RRB- cord-005453-4057qib7 10592 6 Conclusions conclusion NNS cord-005453-4057qib7 10592 7 : : : cord-005453-4057qib7 10593 1 CMV CMV NNP cord-005453-4057qib7 10593 2 reactivation reactivation NN cord-005453-4057qib7 10593 3 was be VBD cord-005453-4057qib7 10593 4 seen see VBN cord-005453-4057qib7 10593 5 in in IN cord-005453-4057qib7 10593 6 81 81 CD cord-005453-4057qib7 10593 7 % % NN cord-005453-4057qib7 10593 8 of of IN cord-005453-4057qib7 10593 9 the the DT cord-005453-4057qib7 10593 10 transplant transplant NN cord-005453-4057qib7 10593 11 recipients recipient NNS cord-005453-4057qib7 10593 12 , , , cord-005453-4057qib7 10593 13 this this DT cord-005453-4057qib7 10593 14 is be VBZ cord-005453-4057qib7 10593 15 higher high JJR cord-005453-4057qib7 10593 16 compared compare VBN cord-005453-4057qib7 10593 17 to to IN cord-005453-4057qib7 10593 18 the the DT cord-005453-4057qib7 10593 19 western western JJ cord-005453-4057qib7 10593 20 world world NN cord-005453-4057qib7 10593 21 due due JJ cord-005453-4057qib7 10593 22 to to IN cord-005453-4057qib7 10593 23 high high JJ cord-005453-4057qib7 10593 24 CMV CMV NNP cord-005453-4057qib7 10593 25 seropositivity seropositivity NN cord-005453-4057qib7 10593 26 is be VBZ cord-005453-4057qib7 10593 27 this this DT cord-005453-4057qib7 10593 28 region region NN cord-005453-4057qib7 10593 29 . . . cord-005453-4057qib7 10594 1 Steroids Steroids NNP cord-005453-4057qib7 10594 2 administration administration NN cord-005453-4057qib7 10594 3 in in IN cord-005453-4057qib7 10594 4 post post JJ cord-005453-4057qib7 10594 5 - - JJ cord-005453-4057qib7 10594 6 transplant transplant JJ cord-005453-4057qib7 10594 7 period period NN cord-005453-4057qib7 10594 8 significantly significantly RB cord-005453-4057qib7 10594 9 increase increase VBP cord-005453-4057qib7 10594 10 the the DT cord-005453-4057qib7 10594 11 risk risk NN cord-005453-4057qib7 10594 12 of of IN cord-005453-4057qib7 10594 13 CMV CMV NNP cord-005453-4057qib7 10594 14 reactivation reactivation NN cord-005453-4057qib7 10594 15 . . . cord-005453-4057qib7 10595 1 Preemptive preemptive JJ cord-005453-4057qib7 10595 2 therapy therapy NN cord-005453-4057qib7 10595 3 with with IN cord-005453-4057qib7 10595 4 valganciclovir valganciclovir NNP cord-005453-4057qib7 10595 5 effectively effectively RB cord-005453-4057qib7 10595 6 treats treat VBZ cord-005453-4057qib7 10595 7 CMV CMV NNP cord-005453-4057qib7 10595 8 reactivation reactivation NN cord-005453-4057qib7 10595 9 with with IN cord-005453-4057qib7 10595 10 acceptable acceptable JJ cord-005453-4057qib7 10595 11 side side NN cord-005453-4057qib7 10595 12 effects effect NNS cord-005453-4057qib7 10595 13 . . . cord-005453-4057qib7 10596 1 Viral viral JJ cord-005453-4057qib7 10596 2 threshold threshold NN cord-005453-4057qib7 10596 3 for for IN cord-005453-4057qib7 10596 4 treatment treatment NN cord-005453-4057qib7 10596 5 should should MD cord-005453-4057qib7 10596 6 be be VB cord-005453-4057qib7 10596 7 decided decide VBN cord-005453-4057qib7 10596 8 considering consider VBG cord-005453-4057qib7 10596 9 the the DT cord-005453-4057qib7 10596 10 regional regional JJ cord-005453-4057qib7 10596 11 endemicity endemicity NN cord-005453-4057qib7 10596 12 . . . cord-005453-4057qib7 10597 1 CMV CMV NNP cord-005453-4057qib7 10597 2 adversely adversely RB cord-005453-4057qib7 10597 3 affects affect VBZ cord-005453-4057qib7 10597 4 the the DT cord-005453-4057qib7 10597 5 transplant transplant NN cord-005453-4057qib7 10597 6 outcome outcome NN cord-005453-4057qib7 10597 7 in in IN cord-005453-4057qib7 10597 8 terms term NNS cord-005453-4057qib7 10597 9 of of IN cord-005453-4057qib7 10597 10 DFS DFS NNP cord-005453-4057qib7 10597 11 and and CC cord-005453-4057qib7 10597 12 OS OS NNP cord-005453-4057qib7 10597 13 . . . cord-005453-4057qib7 10598 1 Disclosure disclosure NN cord-005453-4057qib7 10598 2 : : : cord-005453-4057qib7 10599 1 No no DT cord-005453-4057qib7 10599 2 conflict conflict NN cord-005453-4057qib7 10599 3 of of IN cord-005453-4057qib7 10599 4 interest interest NN cord-005453-4057qib7 10599 5 . . . cord-005453-4057qib7 10600 1 Acute acute JJ cord-005453-4057qib7 10600 2 nephritis nephritis NN cord-005453-4057qib7 10600 3 requiring require VBG cord-005453-4057qib7 10600 4 nephrectomy nephrectomy NN cord-005453-4057qib7 10600 5 caused cause VBN cord-005453-4057qib7 10600 6 by by IN cord-005453-4057qib7 10600 7 adenovirus adenovirus NN cord-005453-4057qib7 10600 8 ( ( -LRB- cord-005453-4057qib7 10600 9 HADV HADV NNP cord-005453-4057qib7 10600 10 ) ) -RRB- cord-005453-4057qib7 10600 11 and and CC cord-005453-4057qib7 10600 12 human human JJ cord-005453-4057qib7 10600 13 polyomavirus polyomavirus NNP cord-005453-4057qib7 10600 14 BK BK NNP cord-005453-4057qib7 10600 15 ( ( -LRB- cord-005453-4057qib7 10600 16 BKPYV BKPYV NNP cord-005453-4057qib7 10600 17 ) ) -RRB- cord-005453-4057qib7 10600 18 following follow VBG cord-005453-4057qib7 10600 19 allogeneic allogeneic NN cord-005453-4057qib7 10600 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 10600 21 stem stem NN cord-005453-4057qib7 10600 22 - - HYPH cord-005453-4057qib7 10600 23 cell cell NN cord-005453-4057qib7 10600 24 transplantation transplantation NN cord-005453-4057qib7 10600 25 in in IN cord-005453-4057qib7 10600 26 a a DT cord-005453-4057qib7 10600 27 patient patient NN cord-005453-4057qib7 10600 28 with with IN cord-005453-4057qib7 10600 29 PH+ PH+ NNP cord-005453-4057qib7 10601 1 all all DT cord-005453-4057qib7 10601 2 Background Background NNP cord-005453-4057qib7 10602 1 : : : cord-005453-4057qib7 10602 2 Adenovirus Adenovirus NNP cord-005453-4057qib7 10602 3 infection infection NN cord-005453-4057qib7 10602 4 represents represent VBZ cord-005453-4057qib7 10602 5 an an DT cord-005453-4057qib7 10602 6 important important JJ cord-005453-4057qib7 10602 7 cause cause NN cord-005453-4057qib7 10602 8 of of IN cord-005453-4057qib7 10602 9 morbidity morbidity NN cord-005453-4057qib7 10602 10 and and CC cord-005453-4057qib7 10602 11 mortality mortality NN cord-005453-4057qib7 10602 12 after after IN cord-005453-4057qib7 10602 13 allogeneic allogeneic JJ cord-005453-4057qib7 10602 14 hematopoietic hematopoietic JJ cord-005453-4057qib7 10602 15 stem stem NN cord-005453-4057qib7 10602 16 cell cell NN cord-005453-4057qib7 10602 17 transplantation transplantation NN cord-005453-4057qib7 10602 18 ( ( -LRB- cord-005453-4057qib7 10602 19 allo allo NN cord-005453-4057qib7 10602 20 - - HYPH cord-005453-4057qib7 10602 21 HSCT HSCT NNP cord-005453-4057qib7 10602 22 ) ) -RRB- cord-005453-4057qib7 10602 23 , , , cord-005453-4057qib7 10602 24 with with IN cord-005453-4057qib7 10602 25 no no DT cord-005453-4057qib7 10602 26 established establish VBN cord-005453-4057qib7 10602 27 therapy therapy NN cord-005453-4057qib7 10602 28 . . . cord-005453-4057qib7 10603 1 Although although IN cord-005453-4057qib7 10603 2 different different JJ cord-005453-4057qib7 10603 3 organs organ NNS cord-005453-4057qib7 10603 4 may may MD cord-005453-4057qib7 10603 5 be be VB cord-005453-4057qib7 10603 6 affected affect VBN cord-005453-4057qib7 10603 7 by by IN cord-005453-4057qib7 10603 8 disseminated disseminate VBN cord-005453-4057qib7 10603 9 HAdV hadv JJ cord-005453-4057qib7 10603 10 infections infection NNS cord-005453-4057qib7 10603 11 , , , cord-005453-4057qib7 10603 12 kidney kidney NN cord-005453-4057qib7 10603 13 involvement involvement NN cord-005453-4057qib7 10603 14 has have VBZ cord-005453-4057qib7 10603 15 been be VBN cord-005453-4057qib7 10603 16 rarely rarely RB cord-005453-4057qib7 10603 17 reported report VBN cord-005453-4057qib7 10603 18 . . . cord-005453-4057qib7 10604 1 Co Co NNS cord-005453-4057qib7 10604 2 - - NN cord-005453-4057qib7 10604 3 infection infection NN cord-005453-4057qib7 10604 4 of of IN cord-005453-4057qib7 10604 5 HAdV hadv NN cord-005453-4057qib7 10604 6 and and CC cord-005453-4057qib7 10604 7 BKPyV bkpyv NN cord-005453-4057qib7 10604 8 are be VBP cord-005453-4057qib7 10604 9 common common JJ cord-005453-4057qib7 10604 10 complication complication NN cord-005453-4057qib7 10604 11 in in IN cord-005453-4057qib7 10604 12 patients patient NNS cord-005453-4057qib7 10604 13 undergoing undergo VBG cord-005453-4057qib7 10604 14 allo allo NN cord-005453-4057qib7 10604 15 - - HYPH cord-005453-4057qib7 10604 16 HSCT HSCT NNP cord-005453-4057qib7 10604 17 , , , cord-005453-4057qib7 10604 18 but but CC cord-005453-4057qib7 10604 19 recent recent JJ cord-005453-4057qib7 10604 20 studies study NNS cord-005453-4057qib7 10604 21 demonstrate demonstrate VBP cord-005453-4057qib7 10604 22 that that IN cord-005453-4057qib7 10604 23 BKPyV bkpyv PRP cord-005453-4057qib7 10604 24 may may MD cord-005453-4057qib7 10604 25 facilitate facilitate VB cord-005453-4057qib7 10604 26 the the DT cord-005453-4057qib7 10604 27 replication replication NN cord-005453-4057qib7 10604 28 of of IN cord-005453-4057qib7 10604 29 HAdV hadv NN cord-005453-4057qib7 10604 30 and and CC cord-005453-4057qib7 10604 31 lead lead VB cord-005453-4057qib7 10604 32 to to IN cord-005453-4057qib7 10604 33 elevated elevated JJ cord-005453-4057qib7 10604 34 viremia viremia NN cord-005453-4057qib7 10604 35 with with IN cord-005453-4057qib7 10604 36 increased increase VBN cord-005453-4057qib7 10604 37 virulence virulence NN cord-005453-4057qib7 10604 38 and and CC cord-005453-4057qib7 10604 39 serious serious JJ cord-005453-4057qib7 10604 40 clinical clinical JJ cord-005453-4057qib7 10604 41 consequences consequence NNS cord-005453-4057qib7 10604 42 . . . cord-005453-4057qib7 10605 1 Here here RB cord-005453-4057qib7 10605 2 we -PRON- PRP cord-005453-4057qib7 10605 3 report report VBP cord-005453-4057qib7 10605 4 a a DT cord-005453-4057qib7 10605 5 case case NN cord-005453-4057qib7 10605 6 of of IN cord-005453-4057qib7 10605 7 an an DT cord-005453-4057qib7 10605 8 adult adult NN cord-005453-4057qib7 10605 9 patient patient NN cord-005453-4057qib7 10605 10 who who WP cord-005453-4057qib7 10605 11 required require VBD cord-005453-4057qib7 10605 12 a a DT cord-005453-4057qib7 10605 13 monolateral monolateral JJ cord-005453-4057qib7 10605 14 nephrectomy nephrectomy NN cord-005453-4057qib7 10605 15 due due IN cord-005453-4057qib7 10605 16 to to IN cord-005453-4057qib7 10605 17 HAdV hadv JJ cord-005453-4057qib7 10605 18 pyelonephritis pyelonephritis NN cord-005453-4057qib7 10605 19 as as IN cord-005453-4057qib7 10605 20 an an DT cord-005453-4057qib7 10605 21 early early JJ cord-005453-4057qib7 10605 22 complication complication NN cord-005453-4057qib7 10605 23 of of IN cord-005453-4057qib7 10605 24 allo allo NN cord-005453-4057qib7 10605 25 - - HYPH cord-005453-4057qib7 10605 26 HSCT HSCT NNP cord-005453-4057qib7 10605 27 for for IN cord-005453-4057qib7 10605 28 Philadelphia Philadelphia NNP cord-005453-4057qib7 10605 29 - - HYPH cord-005453-4057qib7 10605 30 positive positive JJ cord-005453-4057qib7 10605 31 acute acute JJ cord-005453-4057qib7 10605 32 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 10605 33 leukemia leukemia NN cord-005453-4057qib7 10606 1 ( ( -LRB- cord-005453-4057qib7 10606 2 Ph+ Ph+ NNP cord-005453-4057qib7 10606 3 ALL all DT cord-005453-4057qib7 10606 4 ) ) -RRB- cord-005453-4057qib7 10606 5 . . . cord-005453-4057qib7 10607 1 Methods method NNS cord-005453-4057qib7 10607 2 : : : cord-005453-4057qib7 10607 3 In in IN cord-005453-4057qib7 10607 4 September September NNP cord-005453-4057qib7 10607 5 2014 2014 CD cord-005453-4057qib7 10607 6 , , , cord-005453-4057qib7 10607 7 an an DT cord-005453-4057qib7 10607 8 ethiopian ethiopian JJ cord-005453-4057qib7 10607 9 gentleman gentleman NN cord-005453-4057qib7 10607 10 was be VBD cord-005453-4057qib7 10607 11 diagnosed diagnose VBN cord-005453-4057qib7 10607 12 with with IN cord-005453-4057qib7 10607 13 Ph+ Ph+ NNP cord-005453-4057qib7 10607 14 ALL all RB cord-005453-4057qib7 10607 15 at at IN cord-005453-4057qib7 10607 16 the the DT cord-005453-4057qib7 10607 17 age age NN cord-005453-4057qib7 10607 18 of of IN cord-005453-4057qib7 10607 19 24 24 CD cord-005453-4057qib7 10607 20 years year NNS cord-005453-4057qib7 10607 21 . . . cord-005453-4057qib7 10608 1 He -PRON- PRP cord-005453-4057qib7 10608 2 was be VBD cord-005453-4057qib7 10608 3 treated treat VBN cord-005453-4057qib7 10608 4 with with IN cord-005453-4057qib7 10608 5 polychemotherapy polychemotherapy NNP cord-005453-4057qib7 10608 6 in in IN cord-005453-4057qib7 10608 7 association association NNP cord-005453-4057qib7 10608 8 with with IN cord-005453-4057qib7 10608 9 the the DT cord-005453-4057qib7 10608 10 tyrosin tyrosin NNP cord-005453-4057qib7 10608 11 kinase kinase NNP cord-005453-4057qib7 10608 12 inhibitor inhibitor NN cord-005453-4057qib7 10608 13 imatinib imatinib NNP cord-005453-4057qib7 10608 14 mesylate mesylate NNP cord-005453-4057qib7 10608 15 achieving achieve VBG cord-005453-4057qib7 10608 16 a a DT cord-005453-4057qib7 10608 17 complete complete JJ cord-005453-4057qib7 10608 18 remission remission NN cord-005453-4057qib7 10608 19 ( ( -LRB- cord-005453-4057qib7 10608 20 CR CR NNP cord-005453-4057qib7 10608 21 ) ) -RRB- cord-005453-4057qib7 10608 22 . . . cord-005453-4057qib7 10609 1 One one CD cord-005453-4057qib7 10609 2 year year NN cord-005453-4057qib7 10609 3 later later RB cord-005453-4057qib7 10609 4 , , , cord-005453-4057qib7 10609 5 due due IN cord-005453-4057qib7 10609 6 to to IN cord-005453-4057qib7 10609 7 disease disease NN cord-005453-4057qib7 10609 8 relapse relapse VB cord-005453-4057qib7 10609 9 with with IN cord-005453-4057qib7 10609 10 CNS CNS NNP cord-005453-4057qib7 10609 11 involvement involvement NN cord-005453-4057qib7 10609 12 , , , cord-005453-4057qib7 10609 13 he -PRON- PRP cord-005453-4057qib7 10609 14 was be VBD cord-005453-4057qib7 10609 15 started start VBN cord-005453-4057qib7 10609 16 on on IN cord-005453-4057qib7 10609 17 vincristine vincristine NN cord-005453-4057qib7 10609 18 and and CC cord-005453-4057qib7 10609 19 dexamethasone dexamethasone NN cord-005453-4057qib7 10609 20 plus plus CC cord-005453-4057qib7 10609 21 imatinib imatinib JJ cord-005453-4057qib7 10609 22 treatment treatment NN cord-005453-4057qib7 10609 23 and and CC cord-005453-4057qib7 10609 24 in in IN cord-005453-4057qib7 10609 25 April April NNP cord-005453-4057qib7 10609 26 2017 2017 CD cord-005453-4057qib7 10609 27 he -PRON- PRP cord-005453-4057qib7 10609 28 was be VBD cord-005453-4057qib7 10609 29 referred refer VBN cord-005453-4057qib7 10609 30 to to IN cord-005453-4057qib7 10609 31 our -PRON- PRP$ cord-005453-4057qib7 10609 32 BMT BMT NNP cord-005453-4057qib7 10609 33 Center Center NNP cord-005453-4057qib7 10609 34 from from IN cord-005453-4057qib7 10609 35 Ethiopia Ethiopia NNP cord-005453-4057qib7 10609 36 . . . cord-005453-4057qib7 10610 1 Upon upon IN cord-005453-4057qib7 10610 2 confirmation confirmation NN cord-005453-4057qib7 10610 3 of of IN cord-005453-4057qib7 10610 4 the the DT cord-005453-4057qib7 10610 5 p210 p210 NN cord-005453-4057qib7 10610 6 Ph+ Ph+ NNP cord-005453-4057qib7 10610 7 B B NNP cord-005453-4057qib7 10610 8 - - : cord-005453-4057qib7 10610 9 ALL all DT cord-005453-4057qib7 10610 10 diagnosis diagnosis NN cord-005453-4057qib7 10610 11 , , , cord-005453-4057qib7 10610 12 therapy therapy NN cord-005453-4057qib7 10610 13 with with IN cord-005453-4057qib7 10610 14 the the DT cord-005453-4057qib7 10610 15 Scr Scr NNP cord-005453-4057qib7 10610 16 / / SYM cord-005453-4057qib7 10610 17 Abl Abl NNP cord-005453-4057qib7 10610 18 dual dual JJ cord-005453-4057qib7 10610 19 inhibitor inhibitor NN cord-005453-4057qib7 10610 20 dasatinib dasatinib NN cord-005453-4057qib7 10610 21 associated associate VBN cord-005453-4057qib7 10610 22 to to IN cord-005453-4057qib7 10610 23 intrathecal intrathecal JJ cord-005453-4057qib7 10610 24 chemotherapy chemotherapy NN cord-005453-4057qib7 10610 25 was be VBD cord-005453-4057qib7 10610 26 started start VBN cord-005453-4057qib7 10610 27 and and CC cord-005453-4057qib7 10610 28 a a DT cord-005453-4057qib7 10610 29 salvage salvage NN cord-005453-4057qib7 10610 30 treatment treatment NN cord-005453-4057qib7 10610 31 with with IN cord-005453-4057qib7 10610 32 inotuzumab inotuzumab NNS cord-005453-4057qib7 10610 33 ozogamicin ozogamicin NNS cord-005453-4057qib7 10610 34 followed follow VBN cord-005453-4057qib7 10610 35 by by IN cord-005453-4057qib7 10610 36 an an DT cord-005453-4057qib7 10610 37 allogeneic allogeneic JJ cord-005453-4057qib7 10610 38 HSCT HSCT NNP cord-005453-4057qib7 10610 39 from from IN cord-005453-4057qib7 10610 40 a a DT cord-005453-4057qib7 10610 41 HLA HLA NNP cord-005453-4057qib7 10610 42 - - HYPH cord-005453-4057qib7 10610 43 identical identical JJ cord-005453-4057qib7 10610 44 brother brother NN cord-005453-4057qib7 10610 45 was be VBD cord-005453-4057qib7 10610 46 planned plan VBN cord-005453-4057qib7 10610 47 . . . cord-005453-4057qib7 10611 1 Having have VBG cord-005453-4057qib7 10611 2 achieved achieve VBN cord-005453-4057qib7 10611 3 a a DT cord-005453-4057qib7 10611 4 documented document VBN cord-005453-4057qib7 10611 5 molecular molecular JJ cord-005453-4057qib7 10611 6 CR cr NN cord-005453-4057qib7 10611 7 disease disease NN cord-005453-4057qib7 10611 8 status status NN cord-005453-4057qib7 10611 9 , , , cord-005453-4057qib7 10611 10 in in IN cord-005453-4057qib7 10611 11 June June NNP cord-005453-4057qib7 10611 12 2017 2017 CD cord-005453-4057qib7 10611 13 the the DT cord-005453-4057qib7 10611 14 patient patient NN cord-005453-4057qib7 10611 15 underwent undergo VBD cord-005453-4057qib7 10611 16 allo allo NN cord-005453-4057qib7 10611 17 - - HYPH cord-005453-4057qib7 10611 18 HSCT HSCT NNP cord-005453-4057qib7 10611 19 following follow VBG cord-005453-4057qib7 10611 20 the the DT cord-005453-4057qib7 10611 21 fludarabine fludarabine NN cord-005453-4057qib7 10611 22 - - HYPH cord-005453-4057qib7 10611 23 melphalan melphalan NNP cord-005453-4057qib7 10611 24 reduced reduce VBN cord-005453-4057qib7 10611 25 - - HYPH cord-005453-4057qib7 10611 26 intensity intensity NN cord-005453-4057qib7 10611 27 conditioning conditioning NN cord-005453-4057qib7 10611 28 regimen regimen NN cord-005453-4057qib7 10611 29 . . . cord-005453-4057qib7 10612 1 Graft graft NN cord-005453-4057qib7 10612 2 - - HYPH cord-005453-4057qib7 10612 3 versus versus IN cord-005453-4057qib7 10612 4 - - HYPH cord-005453-4057qib7 10612 5 host host NN cord-005453-4057qib7 10612 6 prophylaxis prophylaxis NN cord-005453-4057qib7 10612 7 included include VBD cord-005453-4057qib7 10612 8 anti anti JJ cord-005453-4057qib7 10612 9 - - JJ cord-005453-4057qib7 10612 10 thymocyte thymocyte JJ cord-005453-4057qib7 10612 11 globulin globulin NN cord-005453-4057qib7 10612 12 , , , cord-005453-4057qib7 10612 13 cyclosporine cyclosporine NN cord-005453-4057qib7 10612 14 and and CC cord-005453-4057qib7 10612 15 mycophenolate mycophenolate NNP cord-005453-4057qib7 10613 1 mofetil mofetil NNP cord-005453-4057qib7 10613 2 Results result NNS cord-005453-4057qib7 10614 1 : : : cord-005453-4057qib7 10614 2 On on IN cord-005453-4057qib7 10614 3 day day NN cord-005453-4057qib7 10614 4 +24 +24 CD cord-005453-4057qib7 10614 5 post post NN cord-005453-4057qib7 10614 6 - - NN cord-005453-4057qib7 10614 7 transplantation transplantation JJ cord-005453-4057qib7 10614 8 the the DT cord-005453-4057qib7 10614 9 patient patient NN cord-005453-4057qib7 10614 10 developed develop VBD cord-005453-4057qib7 10614 11 macro macro NN cord-005453-4057qib7 10614 12 - - HYPH cord-005453-4057qib7 10614 13 hematuria hematuria NN cord-005453-4057qib7 10614 14 due due IN cord-005453-4057qib7 10614 15 to to IN cord-005453-4057qib7 10614 16 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 10614 17 cystitis cystitis NN cord-005453-4057qib7 10614 18 and and CC cord-005453-4057qib7 10614 19 a a DT cord-005453-4057qib7 10614 20 CT CT NNP cord-005453-4057qib7 10614 21 scan scan NN cord-005453-4057qib7 10614 22 unveiled unveil VBD cord-005453-4057qib7 10614 23 a a DT cord-005453-4057qib7 10614 24 left left JJ cord-005453-4057qib7 10614 25 pyelonephritis pyelonephritis NN cord-005453-4057qib7 10614 26 with with IN cord-005453-4057qib7 10614 27 marked marked JJ cord-005453-4057qib7 10614 28 kidney kidney NN cord-005453-4057qib7 10614 29 enlargement enlargement NN cord-005453-4057qib7 10614 30 . . . cord-005453-4057qib7 10615 1 Kidney kidney NN cord-005453-4057qib7 10615 2 microbial microbial JJ cord-005453-4057qib7 10615 3 investigations investigation NNS cord-005453-4057qib7 10615 4 were be VBD cord-005453-4057qib7 10615 5 all all DT cord-005453-4057qib7 10615 6 negative negative JJ cord-005453-4057qib7 10615 7 . . . cord-005453-4057qib7 10616 1 At at IN cord-005453-4057qib7 10616 2 the the DT cord-005453-4057qib7 10616 3 same same JJ cord-005453-4057qib7 10616 4 time time NN cord-005453-4057qib7 10616 5 , , , cord-005453-4057qib7 10616 6 HAdV hadv JJ cord-005453-4057qib7 10616 7 viremia viremia NN cord-005453-4057qib7 10616 8 with with IN cord-005453-4057qib7 10616 9 very very RB cord-005453-4057qib7 10616 10 high high JJ cord-005453-4057qib7 10616 11 copy copy NN cord-005453-4057qib7 10616 12 number number NN cord-005453-4057qib7 10616 13 ( ( -LRB- cord-005453-4057qib7 10616 14 > > NFP cord-005453-4057qib7 10616 15 25000000 25000000 CD cord-005453-4057qib7 10616 16 cp cp NNS cord-005453-4057qib7 10616 17 / / SYM cord-005453-4057qib7 10616 18 ml ml NN cord-005453-4057qib7 10616 19 ) ) -RRB- cord-005453-4057qib7 10616 20 was be VBD cord-005453-4057qib7 10616 21 documented document VBN cord-005453-4057qib7 10616 22 and and CC cord-005453-4057qib7 10616 23 also also RB cord-005453-4057qib7 10616 24 elevated elevate VBN cord-005453-4057qib7 10616 25 BKPyV bkpyv NN cord-005453-4057qib7 10616 26 ( ( -LRB- cord-005453-4057qib7 10617 1 > > NFP cord-005453-4057qib7 10617 2 25000000 25000000 CD cord-005453-4057qib7 10617 3 cp cp NNS cord-005453-4057qib7 10617 4 / / SYM cord-005453-4057qib7 10617 5 ml ml NNP cord-005453-4057qib7 10617 6 ) ) -RRB- cord-005453-4057qib7 10617 7 viruria viruria NNP cord-005453-4057qib7 10617 8 and and CC cord-005453-4057qib7 10617 9 viremia viremia NNP cord-005453-4057qib7 10617 10 ( ( -LRB- cord-005453-4057qib7 10617 11 6400 6400 CD cord-005453-4057qib7 10617 12 cp cp NN cord-005453-4057qib7 10617 13 / / SYM cord-005453-4057qib7 10617 14 ml ml NN cord-005453-4057qib7 10617 15 ) ) -RRB- cord-005453-4057qib7 10617 16 . . . cord-005453-4057qib7 10618 1 The the DT cord-005453-4057qib7 10618 2 genotyping genotyping NN cord-005453-4057qib7 10618 3 of of IN cord-005453-4057qib7 10618 4 HAdV hadv NN cord-005453-4057qib7 10618 5 evidenced evidenced JJ cord-005453-4057qib7 10618 6 serotype serotype NN cord-005453-4057qib7 10618 7 B11 B11 NNP cord-005453-4057qib7 10618 8 mainly mainly RB cord-005453-4057qib7 10618 9 involved involve VBN cord-005453-4057qib7 10618 10 in in IN cord-005453-4057qib7 10618 11 infections infection NNS cord-005453-4057qib7 10618 12 of of IN cord-005453-4057qib7 10618 13 the the DT cord-005453-4057qib7 10618 14 urinary urinary JJ cord-005453-4057qib7 10618 15 tract tract NN cord-005453-4057qib7 10618 16 . . . cord-005453-4057qib7 10619 1 Treatment treatment NN cord-005453-4057qib7 10619 2 with with IN cord-005453-4057qib7 10619 3 cidofovir cidofovir NNS cord-005453-4057qib7 10619 4 was be VBD cord-005453-4057qib7 10619 5 immediately immediately RB cord-005453-4057qib7 10619 6 started start VBN cord-005453-4057qib7 10619 7 ; ; : cord-005453-4057qib7 10619 8 nonetheless nonetheless RB cord-005453-4057qib7 10619 9 , , , cord-005453-4057qib7 10619 10 due due IN cord-005453-4057qib7 10619 11 to to IN cord-005453-4057qib7 10619 12 rapid rapid JJ cord-005453-4057qib7 10619 13 clinical clinical JJ cord-005453-4057qib7 10619 14 worsening worsen VBG cord-005453-4057qib7 10619 15 despite despite IN cord-005453-4057qib7 10619 16 maximal maximal JJ cord-005453-4057qib7 10619 17 antibiotic antibiotic JJ cord-005453-4057qib7 10619 18 therapy therapy NN cord-005453-4057qib7 10619 19 , , , cord-005453-4057qib7 10619 20 on on IN cord-005453-4057qib7 10619 21 day day NN cord-005453-4057qib7 10619 22 +50 +50 NN cord-005453-4057qib7 10619 23 a a DT cord-005453-4057qib7 10619 24 left left JJ cord-005453-4057qib7 10619 25 nephrectomy nephrectomy NN cord-005453-4057qib7 10619 26 was be VBD cord-005453-4057qib7 10619 27 performed perform VBN cord-005453-4057qib7 10619 28 , , , cord-005453-4057qib7 10619 29 which which WDT cord-005453-4057qib7 10619 30 led lead VBD cord-005453-4057qib7 10619 31 to to IN cord-005453-4057qib7 10619 32 a a DT cord-005453-4057qib7 10619 33 subsequent subsequent JJ cord-005453-4057qib7 10619 34 progressive progressive JJ cord-005453-4057qib7 10619 35 resolution resolution NN cord-005453-4057qib7 10619 36 of of IN cord-005453-4057qib7 10619 37 the the DT cord-005453-4057qib7 10619 38 clinical clinical JJ cord-005453-4057qib7 10619 39 symptoms symptom NNS cord-005453-4057qib7 10619 40 and and CC cord-005453-4057qib7 10619 41 negativization negativization NN cord-005453-4057qib7 10619 42 of of IN cord-005453-4057qib7 10619 43 HAdV HAdV NNP cord-005453-4057qib7 10619 44 and and CC cord-005453-4057qib7 10619 45 BKPyV BKPyV NNP cord-005453-4057qib7 10619 46 viremia viremia NN cord-005453-4057qib7 10619 47 and and CC cord-005453-4057qib7 10619 48 viruria viruria NNP cord-005453-4057qib7 10619 49 . . . cord-005453-4057qib7 10620 1 PCR PCR NNP cord-005453-4057qib7 10620 2 Real real JJ cord-005453-4057qib7 10620 3 time time NN cord-005453-4057qib7 10620 4 performed perform VBN cord-005453-4057qib7 10620 5 on on IN cord-005453-4057qib7 10620 6 the the DT cord-005453-4057qib7 10620 7 kidney kidney NN cord-005453-4057qib7 10620 8 tissue tissue NN cord-005453-4057qib7 10620 9 unveiled unveil VBD cord-005453-4057qib7 10620 10 very very RB cord-005453-4057qib7 10620 11 high high JJ cord-005453-4057qib7 10620 12 concentration concentration NN cord-005453-4057qib7 10620 13 of of IN cord-005453-4057qib7 10620 14 HAdV hadv JJ cord-005453-4057qib7 10620 15 copy copy NN cord-005453-4057qib7 10620 16 number number NN cord-005453-4057qib7 10620 17 . . . cord-005453-4057qib7 10621 1 Conclusions conclusion NNS cord-005453-4057qib7 10621 2 : : : cord-005453-4057qib7 10622 1 Acute acute JJ cord-005453-4057qib7 10622 2 pyelonephritis pyelonephritis NN cord-005453-4057qib7 10622 3 due due IN cord-005453-4057qib7 10622 4 to to IN cord-005453-4057qib7 10622 5 disseminated disseminate VBN cord-005453-4057qib7 10622 6 HAdV hadv JJ cord-005453-4057qib7 10622 7 infection infection NN cord-005453-4057qib7 10622 8 may may MD cord-005453-4057qib7 10622 9 represent represent VB cord-005453-4057qib7 10622 10 a a DT cord-005453-4057qib7 10622 11 possible possible JJ cord-005453-4057qib7 10622 12 cause cause NN cord-005453-4057qib7 10622 13 of of IN cord-005453-4057qib7 10622 14 severe severe JJ cord-005453-4057qib7 10622 15 complication complication NN cord-005453-4057qib7 10622 16 following follow VBG cord-005453-4057qib7 10622 17 allo allo NN cord-005453-4057qib7 10622 18 - - HYPH cord-005453-4057qib7 10622 19 HSCT HSCT NNP cord-005453-4057qib7 10622 20 . . . cord-005453-4057qib7 10623 1 Monitoring monitoring NN cord-005453-4057qib7 10623 2 of of IN cord-005453-4057qib7 10623 3 HAdV hadv JJ cord-005453-4057qib7 10623 4 copy copy NN cord-005453-4057qib7 10623 5 number number NN cord-005453-4057qib7 10623 6 is be VBZ cord-005453-4057qib7 10623 7 helpful helpful JJ cord-005453-4057qib7 10623 8 to to TO cord-005453-4057qib7 10623 9 evaluate evaluate VB cord-005453-4057qib7 10623 10 infection infection NN cord-005453-4057qib7 10623 11 severity severity NN cord-005453-4057qib7 10623 12 and and CC cord-005453-4057qib7 10623 13 response response NN cord-005453-4057qib7 10623 14 to to IN cord-005453-4057qib7 10623 15 treatment treatment NN cord-005453-4057qib7 10623 16 . . . cord-005453-4057qib7 10624 1 Co Co NNS cord-005453-4057qib7 10624 2 - - NN cord-005453-4057qib7 10624 3 infection infection NN cord-005453-4057qib7 10624 4 of of IN cord-005453-4057qib7 10624 5 HAdV hadv NN cord-005453-4057qib7 10624 6 and and CC cord-005453-4057qib7 10624 7 BKPyV bkpyv NN cord-005453-4057qib7 10624 8 in in IN cord-005453-4057qib7 10624 9 immunocompromised immunocompromised JJ cord-005453-4057qib7 10624 10 patients patient NNS cord-005453-4057qib7 10624 11 should should MD cord-005453-4057qib7 10624 12 be be VB cord-005453-4057qib7 10624 13 always always RB cord-005453-4057qib7 10624 14 considered consider VBN cord-005453-4057qib7 10624 15 likely likely JJ cord-005453-4057qib7 10624 16 to to TO cord-005453-4057qib7 10624 17 worsen worsen VB cord-005453-4057qib7 10624 18 clinical clinical JJ cord-005453-4057qib7 10624 19 course course NN cord-005453-4057qib7 10624 20 and and CC cord-005453-4057qib7 10624 21 outcome outcome NN cord-005453-4057qib7 10624 22 . . . cord-005453-4057qib7 10625 1 Disclosure disclosure NN cord-005453-4057qib7 10625 2 : : : cord-005453-4057qib7 10625 3 Nothing nothing NN cord-005453-4057qib7 10625 4 to to TO cord-005453-4057qib7 10625 5 declare declare VB cord-005453-4057qib7 10625 6 Background background NN cord-005453-4057qib7 10625 7 : : : cord-005453-4057qib7 10626 1 Infection infection NN cord-005453-4057qib7 10626 2 is be VBZ cord-005453-4057qib7 10626 3 a a DT cord-005453-4057qib7 10626 4 major major JJ cord-005453-4057qib7 10626 5 cause cause NN cord-005453-4057qib7 10626 6 of of IN cord-005453-4057qib7 10626 7 morbidity morbidity NN cord-005453-4057qib7 10626 8 and and CC cord-005453-4057qib7 10626 9 mortality mortality NN cord-005453-4057qib7 10626 10 in in IN cord-005453-4057qib7 10626 11 patients patient NNS cord-005453-4057qib7 10626 12 ( ( -LRB- cord-005453-4057qib7 10626 13 pts pts NNP cord-005453-4057qib7 10626 14 ) ) -RRB- cord-005453-4057qib7 10626 15 receiving receive VBG cord-005453-4057qib7 10626 16 an an DT cord-005453-4057qib7 10626 17 allo allo NN cord-005453-4057qib7 10626 18 - - HYPH cord-005453-4057qib7 10626 19 HSCT HSCT NNP cord-005453-4057qib7 10626 20 . . . cord-005453-4057qib7 10627 1 Its -PRON- PRP$ cord-005453-4057qib7 10627 2 severity severity NN cord-005453-4057qib7 10627 3 is be VBZ cord-005453-4057qib7 10627 4 related relate VBN cord-005453-4057qib7 10627 5 primarily primarily RB cord-005453-4057qib7 10627 6 to to IN cord-005453-4057qib7 10627 7 the the DT cord-005453-4057qib7 10627 8 depth depth NN cord-005453-4057qib7 10627 9 and and CC cord-005453-4057qib7 10627 10 duration duration NN cord-005453-4057qib7 10627 11 of of IN cord-005453-4057qib7 10627 12 neutropenia neutropenia NN cord-005453-4057qib7 10627 13 . . . cord-005453-4057qib7 10628 1 Febrile febrile JJ cord-005453-4057qib7 10628 2 neutropenia neutropenia NN cord-005453-4057qib7 10628 3 ( ( -LRB- cord-005453-4057qib7 10628 4 FN FN NNP cord-005453-4057qib7 10628 5 ) ) -RRB- cord-005453-4057qib7 10628 6 is be VBZ cord-005453-4057qib7 10628 7 defined define VBN cord-005453-4057qib7 10628 8 as as IN cord-005453-4057qib7 10628 9 a a DT cord-005453-4057qib7 10628 10 neutrophil neutrophil NN cord-005453-4057qib7 10628 11 count count NN cord-005453-4057qib7 10628 12 below below IN cord-005453-4057qib7 10628 13 500 500 CD cord-005453-4057qib7 10628 14 cells cell NNS cord-005453-4057qib7 10628 15 / / SYM cord-005453-4057qib7 10628 16 mm mm NNP cord-005453-4057qib7 10628 17 3 3 CD cord-005453-4057qib7 10628 18 and and CC cord-005453-4057qib7 10628 19 a a DT cord-005453-4057qib7 10628 20 fever fever NN cord-005453-4057qib7 10628 21 ≥ ≥ CD cord-005453-4057qib7 10628 22 38.3 38.3 CD cord-005453-4057qib7 10628 23 ° ° NN cord-005453-4057qib7 10628 24 C c NN cord-005453-4057qib7 10628 25 at at IN cord-005453-4057qib7 10628 26 a a DT cord-005453-4057qib7 10628 27 single single JJ cord-005453-4057qib7 10628 28 measurement measurement NN cord-005453-4057qib7 10628 29 or≥ or≥ NNP cord-005453-4057qib7 10628 30 38 38 CD cord-005453-4057qib7 10628 31 ° ° NN cord-005453-4057qib7 10628 32 C C NNP cord-005453-4057qib7 10628 33 2 2 CD cord-005453-4057qib7 10628 34 times time NNS cord-005453-4057qib7 10628 35 at at IN cord-005453-4057qib7 10628 36 one one CD cord-005453-4057qib7 10628 37 hour hour NN cord-005453-4057qib7 10628 38 intervals interval NNS cord-005453-4057qib7 10628 39 . . . cord-005453-4057qib7 10629 1 The the DT cord-005453-4057qib7 10629 2 objective objective NN cord-005453-4057qib7 10629 3 of of IN cord-005453-4057qib7 10629 4 our -PRON- PRP$ cord-005453-4057qib7 10629 5 study study NN cord-005453-4057qib7 10629 6 is be VBZ cord-005453-4057qib7 10629 7 to to TO cord-005453-4057qib7 10629 8 analyze analyze VB cord-005453-4057qib7 10629 9 the the DT cord-005453-4057qib7 10629 10 epidemiological epidemiological JJ cord-005453-4057qib7 10629 11 , , , cord-005453-4057qib7 10629 12 clinical clinical JJ cord-005453-4057qib7 10629 13 , , , cord-005453-4057qib7 10629 14 biological biological JJ cord-005453-4057qib7 10629 15 characteristics characteristic NNS cord-005453-4057qib7 10629 16 of of IN cord-005453-4057qib7 10629 17 febrile febrile JJ cord-005453-4057qib7 10629 18 episodes episode NNS cord-005453-4057qib7 10629 19 ( ( -LRB- cord-005453-4057qib7 10629 20 FE FE NNP cord-005453-4057qib7 10629 21 ) ) -RRB- cord-005453-4057qib7 10629 22 occurred occur VBD cord-005453-4057qib7 10629 23 in in IN cord-005453-4057qib7 10629 24 136 136 CD cord-005453-4057qib7 10629 25 pts pt NNS cord-005453-4057qib7 10629 26 who who WP cord-005453-4057qib7 10629 27 benefited benefit VBD cord-005453-4057qib7 10629 28 an an DT cord-005453-4057qib7 10629 29 allo allo NN cord-005453-4057qib7 10629 30 - - HYPH cord-005453-4057qib7 10629 31 CSH csh NN cord-005453-4057qib7 10629 32 over over IN cord-005453-4057qib7 10629 33 a a DT cord-005453-4057qib7 10629 34 period period NN cord-005453-4057qib7 10629 35 of of IN cord-005453-4057qib7 10629 36 2 2 CD cord-005453-4057qib7 10629 37 years year NNS cord-005453-4057qib7 10629 38 . . . cord-005453-4057qib7 10630 1 Methods method NNS cord-005453-4057qib7 10630 2 : : : cord-005453-4057qib7 10630 3 From from IN cord-005453-4057qib7 10630 4 January January NNP cord-005453-4057qib7 10630 5 2016 2016 CD cord-005453-4057qib7 10630 6 to to IN cord-005453-4057qib7 10630 7 December December NNP cord-005453-4057qib7 10630 8 2017 2017 CD cord-005453-4057qib7 10630 9 , , , cord-005453-4057qib7 10630 10 136 136 CD cord-005453-4057qib7 10630 11 allo allo NN cord-005453-4057qib7 10630 12 - - HYPH cord-005453-4057qib7 10630 13 HSCT HSCT NNP cord-005453-4057qib7 10630 14 were be VBD cord-005453-4057qib7 10630 15 performed perform VBN cord-005453-4057qib7 10630 16 in in IN cord-005453-4057qib7 10630 17 136 136 CD cord-005453-4057qib7 10630 18 pts pt NNS cord-005453-4057qib7 10630 19 including include VBG cord-005453-4057qib7 10630 20 106 106 CD cord-005453-4057qib7 10630 21 sibling sibling NN cord-005453-4057qib7 10630 22 - - HYPH cord-005453-4057qib7 10630 23 HLA HLA NNP cord-005453-4057qib7 10630 24 identical identical JJ cord-005453-4057qib7 10630 25 , , , cord-005453-4057qib7 10630 26 26 26 CD cord-005453-4057qib7 10630 27 haplo haplo NN cord-005453-4057qib7 10630 28 - - HYPH cord-005453-4057qib7 10630 29 identical identical JJ cord-005453-4057qib7 10630 30 and and CC cord-005453-4057qib7 10630 31 04 04 CD cord-005453-4057qib7 10630 32 phenoidentical phenoidentical JJ cord-005453-4057qib7 10630 33 for for IN cord-005453-4057qib7 10630 34 essentially essentially RB cord-005453-4057qib7 10630 35 acute acute JJ cord-005453-4057qib7 10630 36 leukemia leukemia NN cord-005453-4057qib7 10630 37 ( ( -LRB- cord-005453-4057qib7 10630 38 68 68 CD cord-005453-4057qib7 10630 39 pts pt NNS cord-005453-4057qib7 10630 40 , , , cord-005453-4057qib7 10630 41 50 50 CD cord-005453-4057qib7 10630 42 % % NN cord-005453-4057qib7 10630 43 ) ) -RRB- cord-005453-4057qib7 10630 44 , , , cord-005453-4057qib7 10630 45 acquired acquire VBN cord-005453-4057qib7 10630 46 and and CC cord-005453-4057qib7 10630 47 congenital congenital JJ cord-005453-4057qib7 10630 48 aplasia aplasia NNP cord-005453-4057qib7 10630 49 ( ( -LRB- cord-005453-4057qib7 10630 50 45 45 CD cord-005453-4057qib7 10630 51 pts pt NNS cord-005453-4057qib7 10630 52 , , , cord-005453-4057qib7 10630 53 33 33 CD cord-005453-4057qib7 10630 54 % % NN cord-005453-4057qib7 10630 55 ) ) -RRB- cord-005453-4057qib7 10630 56 . . . cord-005453-4057qib7 10631 1 The the DT cord-005453-4057qib7 10631 2 median median JJ cord-005453-4057qib7 10631 3 age age NN cord-005453-4057qib7 10631 4 is be VBZ cord-005453-4057qib7 10631 5 22 22 CD cord-005453-4057qib7 10631 6 years year NNS cord-005453-4057qib7 10631 7 ( ( -LRB- cord-005453-4057qib7 10631 8 3 3 CD cord-005453-4057qib7 10631 9 - - SYM cord-005453-4057qib7 10631 10 59 59 CD cord-005453-4057qib7 10631 11 ) ) -RRB- cord-005453-4057qib7 10631 12 and and CC cord-005453-4057qib7 10631 13 sex sex NN cord-005453-4057qib7 10631 14 - - HYPH cord-005453-4057qib7 10631 15 ratio ratio NN cord-005453-4057qib7 10631 16 ( ( -LRB- cord-005453-4057qib7 10631 17 M M NNP cord-005453-4057qib7 10631 18 / / SYM cord-005453-4057qib7 10631 19 F F NNP cord-005453-4057qib7 10631 20 ) ) -RRB- cord-005453-4057qib7 10631 21 : : : cord-005453-4057qib7 10632 1 1.72 1.72 CD cord-005453-4057qib7 10632 2 . . . cord-005453-4057qib7 10633 1 Prophylaxis prophylaxis NN cord-005453-4057qib7 10633 2 consisted consist VBD cord-005453-4057qib7 10633 3 on on IN cord-005453-4057qib7 10633 4 isolation isolation NN cord-005453-4057qib7 10633 5 sterile sterile JJ cord-005453-4057qib7 10633 6 room room NN cord-005453-4057qib7 10633 7 with with IN cord-005453-4057qib7 10633 8 laminar laminar JJ cord-005453-4057qib7 10633 9 flow flow NN cord-005453-4057qib7 10633 10 , , , cord-005453-4057qib7 10633 11 digestive digestive JJ cord-005453-4057qib7 10633 12 decontamination decontamination NN cord-005453-4057qib7 10633 13 , , , cord-005453-4057qib7 10633 14 fluconazole fluconazole NN cord-005453-4057qib7 10633 15 and and CC cord-005453-4057qib7 10633 16 Aciclovir Aciclovir NNP cord-005453-4057qib7 10633 17 . . . cord-005453-4057qib7 10634 1 Nine nine CD cord-005453-4057qib7 10634 2 pts pts NN cord-005453-4057qib7 10634 3 ( ( -LRB- cord-005453-4057qib7 10634 4 6.6 6.6 CD cord-005453-4057qib7 10634 5 % % NN cord-005453-4057qib7 10634 6 ) ) -RRB- cord-005453-4057qib7 10634 7 were be VBD cord-005453-4057qib7 10634 8 infected infect VBN cord-005453-4057qib7 10634 9 at at IN cord-005453-4057qib7 10634 10 the the DT cord-005453-4057qib7 10634 11 time time NN cord-005453-4057qib7 10634 12 of of IN cord-005453-4057qib7 10634 13 hospitalization hospitalization NN cord-005453-4057qib7 10634 14 ( ( -LRB- cord-005453-4057qib7 10634 15 cellulitis cellulitis NNP cord-005453-4057qib7 10634 16 03 03 CD cord-005453-4057qib7 10634 17 , , , cord-005453-4057qib7 10634 18 pneumoniae pneumoniae NN cord-005453-4057qib7 10634 19 02 02 CD cord-005453-4057qib7 10634 20 , , , cord-005453-4057qib7 10634 21 bacterial bacterial JJ cord-005453-4057qib7 10634 22 angina angina NN cord-005453-4057qib7 10634 23 01 01 CD cord-005453-4057qib7 10634 24 , , , cord-005453-4057qib7 10634 25 veinitis veinitis NNP cord-005453-4057qib7 10634 26 01 01 CD cord-005453-4057qib7 10634 27 , , , cord-005453-4057qib7 10634 28 bronchial bronchial JJ cord-005453-4057qib7 10634 29 pneumonia pneumonia NN cord-005453-4057qib7 10634 30 01 01 CD cord-005453-4057qib7 10634 31 , , , cord-005453-4057qib7 10634 32 furuncle furuncle NNP cord-005453-4057qib7 10634 33 cutaneous cutaneous JJ cord-005453-4057qib7 10634 34 01 01 CD cord-005453-4057qib7 10634 35 ) ) -RRB- cord-005453-4057qib7 10634 36 requiring require VBG cord-005453-4057qib7 10634 37 treatment treatment NN cord-005453-4057qib7 10634 38 with with IN cord-005453-4057qib7 10634 39 antibiotics antibiotic NNS cord-005453-4057qib7 10634 40 . . . cord-005453-4057qib7 10635 1 Conditioning conditioning NN cord-005453-4057qib7 10635 2 regimen regimen NN cord-005453-4057qib7 10635 3 is be VBZ cord-005453-4057qib7 10635 4 myeloablative myeloablative JJ cord-005453-4057qib7 10635 5 in in IN cord-005453-4057qib7 10635 6 all all DT cord-005453-4057qib7 10635 7 pts pt NNS cord-005453-4057qib7 10635 8 . . . cord-005453-4057qib7 10636 1 Anti anti JJ cord-005453-4057qib7 10636 2 - - JJ cord-005453-4057qib7 10636 3 thymocyte thymocyte JJ cord-005453-4057qib7 10636 4 globulin globulin NN cord-005453-4057qib7 10636 5 is be VBZ cord-005453-4057qib7 10636 6 used use VBN cord-005453-4057qib7 10636 7 in in IN cord-005453-4057qib7 10636 8 61 61 CD cord-005453-4057qib7 10636 9 pts pt NNS cord-005453-4057qib7 10636 10 ( ( -LRB- cord-005453-4057qib7 10636 11 44.8 44.8 CD cord-005453-4057qib7 10636 12 % % NN cord-005453-4057qib7 10636 13 ) ) -RRB- cord-005453-4057qib7 10636 14 . . . cord-005453-4057qib7 10637 1 Peripheral peripheral JJ cord-005453-4057qib7 10637 2 blood blood NN cord-005453-4057qib7 10637 3 stem stem NN cord-005453-4057qib7 10637 4 cells cell NNS cord-005453-4057qib7 10637 5 ( ( -LRB- cord-005453-4057qib7 10637 6 PBSC PBSC NNP cord-005453-4057qib7 10637 7 ) ) -RRB- cord-005453-4057qib7 10637 8 are be VBP cord-005453-4057qib7 10637 9 used use VBN cord-005453-4057qib7 10637 10 in in IN cord-005453-4057qib7 10637 11 117 117 CD cord-005453-4057qib7 10637 12 pts pt NNS cord-005453-4057qib7 10637 13 ( ( -LRB- cord-005453-4057qib7 10637 14 86 86 CD cord-005453-4057qib7 10637 15 % % NN cord-005453-4057qib7 10637 16 ) ) -RRB- cord-005453-4057qib7 10637 17 with with IN cord-005453-4057qib7 10637 18 an an DT cord-005453-4057qib7 10637 19 average average JJ cord-005453-4057qib7 10637 20 level level NN cord-005453-4057qib7 10637 21 of of IN cord-005453-4057qib7 10637 22 CD34 CD34 NNP cord-005453-4057qib7 10637 23 + + CC cord-005453-4057qib7 10637 24 cells cell NNS cord-005453-4057qib7 10637 25 : : : cord-005453-4057qib7 10637 26 7,5.10 7,5.10 CD cord-005453-4057qib7 10637 27 6 6 CD cord-005453-4057qib7 10638 1 /Kg /Kg . cord-005453-4057qib7 10639 1 ( ( -LRB- cord-005453-4057qib7 10639 2 2 2 CD cord-005453-4057qib7 10639 3 . . . cord-005453-4057qib7 10639 4 1 1 CD cord-005453-4057qib7 10639 5 - - SYM cord-005453-4057qib7 10639 6 19.8 19.8 CD cord-005453-4057qib7 10639 7 ) ) -RRB- cord-005453-4057qib7 10639 8 , , , cord-005453-4057qib7 10639 9 bone bone NN cord-005453-4057qib7 10639 10 marrow marrow NN cord-005453-4057qib7 10639 11 ( ( -LRB- cord-005453-4057qib7 10639 12 BM BM NNP cord-005453-4057qib7 10639 13 ) ) -RRB- cord-005453-4057qib7 10639 14 in in IN cord-005453-4057qib7 10639 15 5 5 CD cord-005453-4057qib7 10639 16 pts pt NNS cord-005453-4057qib7 10639 17 with with IN cord-005453-4057qib7 10639 18 a a DT cord-005453-4057qib7 10639 19 mean mean JJ cord-005453-4057qib7 10639 20 level level NN cord-005453-4057qib7 10639 21 of of IN cord-005453-4057qib7 10639 22 nucleated nucleated JJ cord-005453-4057qib7 10639 23 cells cell NNS cord-005453-4057qib7 10639 24 : : : cord-005453-4057qib7 10639 25 3.4 3.4 CD cord-005453-4057qib7 10639 26 X x SYM cord-005453-4057qib7 10639 27 10 10 CD cord-005453-4057qib7 10639 28 8 8 CD cord-005453-4057qib7 10639 29 /Kg /kg NN cord-005453-4057qib7 10639 30 ( ( -LRB- cord-005453-4057qib7 10639 31 0.8 0.8 CD cord-005453-4057qib7 10639 32 - - SYM cord-005453-4057qib7 10639 33 3.6 3.6 CD cord-005453-4057qib7 10639 34 ) ) -RRB- cord-005453-4057qib7 10639 35 and and CC cord-005453-4057qib7 10639 36 the the DT cord-005453-4057qib7 10639 37 association association NN cord-005453-4057qib7 10639 38 of of IN cord-005453-4057qib7 10639 39 PBSC PBSC NNP cord-005453-4057qib7 10639 40 - - HYPH cord-005453-4057qib7 10639 41 BM BM NNP cord-005453-4057qib7 10639 42 in in IN cord-005453-4057qib7 10639 43 14 14 CD cord-005453-4057qib7 10639 44 pts pt NNS cord-005453-4057qib7 10639 45 ( ( -LRB- cord-005453-4057qib7 10639 46 haplo haplo NN cord-005453-4057qib7 10639 47 - - HYPH cord-005453-4057qib7 10639 48 identical identical JJ cord-005453-4057qib7 10639 49 ) ) -RRB- cord-005453-4057qib7 10639 50 . . . cord-005453-4057qib7 10640 1 At at IN cord-005453-4057qib7 10640 2 each each DT cord-005453-4057qib7 10640 3 FE FE NNP cord-005453-4057qib7 10640 4 , , , cord-005453-4057qib7 10640 5 are be VBP cord-005453-4057qib7 10640 6 practiced practice VBN cord-005453-4057qib7 10640 7 : : : cord-005453-4057qib7 10641 1 chest chest NN cord-005453-4057qib7 10641 2 x x NN cord-005453-4057qib7 10641 3 - - NN cord-005453-4057qib7 10641 4 ray ray NN cord-005453-4057qib7 10641 5 , , , cord-005453-4057qib7 10641 6 procalcitonin procalcitonin NNS cord-005453-4057qib7 10641 7 test test NN cord-005453-4057qib7 10641 8 , , , cord-005453-4057qib7 10641 9 blood blood NN cord-005453-4057qib7 10641 10 culture culture NN cord-005453-4057qib7 10641 11 , , , cord-005453-4057qib7 10641 12 microbiological microbiological JJ cord-005453-4057qib7 10641 13 study study NN cord-005453-4057qib7 10641 14 of of IN cord-005453-4057qib7 10641 15 urine urine NN cord-005453-4057qib7 10641 16 and and CC cord-005453-4057qib7 10641 17 stool stool NN cord-005453-4057qib7 10641 18 ( ( -LRB- cord-005453-4057qib7 10641 19 if if IN cord-005453-4057qib7 10641 20 diarrhea diarrhea NN cord-005453-4057qib7 10641 21 ) ) -RRB- cord-005453-4057qib7 10641 22 . . . cord-005453-4057qib7 10642 1 Results result NNS cord-005453-4057qib7 10642 2 : : : cord-005453-4057qib7 10643 1 All all DT cord-005453-4057qib7 10643 2 pts pt NNS cord-005453-4057qib7 10643 3 showed show VBD cord-005453-4057qib7 10643 4 aplasia aplasia NNP cord-005453-4057qib7 10643 5 with with IN cord-005453-4057qib7 10643 6 an an DT cord-005453-4057qib7 10643 7 average average JJ cord-005453-4057qib7 10643 8 duration duration NN cord-005453-4057qib7 10643 9 of of IN cord-005453-4057qib7 10643 10 16 16 CD cord-005453-4057qib7 10643 11 days day NNS cord-005453-4057qib7 10643 12 ( ( -LRB- cord-005453-4057qib7 10643 13 6 6 CD cord-005453-4057qib7 10643 14 - - SYM cord-005453-4057qib7 10643 15 49 49 CD cord-005453-4057qib7 10643 16 ) ) -RRB- cord-005453-4057qib7 10643 17 , , , cord-005453-4057qib7 10643 18 neutrophil neutrophil NN cord-005453-4057qib7 10643 19 engraftment engraftment NN cord-005453-4057qib7 10643 20 was be VBD cord-005453-4057qib7 10643 21 observed observe VBN cord-005453-4057qib7 10643 22 at at IN cord-005453-4057qib7 10643 23 day day NN cord-005453-4057qib7 10643 24 18 18 CD cord-005453-4057qib7 10643 25 ( ( -LRB- cord-005453-4057qib7 10643 26 9 9 CD cord-005453-4057qib7 10643 27 - - SYM cord-005453-4057qib7 10643 28 31 31 CD cord-005453-4057qib7 10643 29 ) ) -RRB- cord-005453-4057qib7 10643 30 . . . cord-005453-4057qib7 10644 1 One one CD cord-005453-4057qib7 10644 2 hundred hundred CD cord-005453-4057qib7 10644 3 and and CC cord-005453-4057qib7 10644 4 twenty twenty CD cord-005453-4057qib7 10644 5 - - HYPH cord-005453-4057qib7 10644 6 nine nine CD cord-005453-4057qib7 10644 7 pts pt NNS cord-005453-4057qib7 10644 8 ( ( -LRB- cord-005453-4057qib7 10644 9 94.8 94.8 CD cord-005453-4057qib7 10644 10 % % NN cord-005453-4057qib7 10644 11 ) ) -RRB- cord-005453-4057qib7 10644 12 presented present VBD cord-005453-4057qib7 10644 13 205 205 CD cord-005453-4057qib7 10644 14 FE FE NNP cord-005453-4057qib7 10644 15 with with IN cord-005453-4057qib7 10644 16 an an DT cord-005453-4057qib7 10644 17 average average NN cord-005453-4057qib7 10644 18 of of IN cord-005453-4057qib7 10644 19 1.5 1.5 CD cord-005453-4057qib7 10644 20 per per IN cord-005453-4057qib7 10644 21 pt pt NN cord-005453-4057qib7 10644 22 . . . cord-005453-4057qib7 10645 1 Eleven eleven CD cord-005453-4057qib7 10645 2 pts pt NNS cord-005453-4057qib7 10645 3 ( ( -LRB- cord-005453-4057qib7 10645 4 8 8 CD cord-005453-4057qib7 10645 5 % % NN cord-005453-4057qib7 10645 6 ) ) -RRB- cord-005453-4057qib7 10645 7 had have VBD cord-005453-4057qib7 10645 8 3 3 CD cord-005453-4057qib7 10645 9 FE FE NNP cord-005453-4057qib7 10645 10 or or CC cord-005453-4057qib7 10645 11 more more JJR cord-005453-4057qib7 10645 12 . . . cord-005453-4057qib7 10646 1 Forty forty CD cord-005453-4057qib7 10646 2 nine nine CD cord-005453-4057qib7 10646 3 ( ( -LRB- cord-005453-4057qib7 10646 4 23,9 23,9 CD cord-005453-4057qib7 10646 5 % % NN cord-005453-4057qib7 10646 6 ) ) -RRB- cord-005453-4057qib7 10647 1 FE FE NNP cord-005453-4057qib7 10647 2 are be VBP cord-005453-4057qib7 10647 3 clinically clinically RB cord-005453-4057qib7 10647 4 documented document VBN cord-005453-4057qib7 10647 5 ( ( -LRB- cord-005453-4057qib7 10647 6 digestive digestive JJ cord-005453-4057qib7 10647 7 : : : cord-005453-4057qib7 10647 8 19 19 CD cord-005453-4057qib7 10647 9 , , , cord-005453-4057qib7 10647 10 skin skin NN cord-005453-4057qib7 10647 11 : : : cord-005453-4057qib7 10647 12 14 14 CD cord-005453-4057qib7 10647 13 , , , cord-005453-4057qib7 10647 14 pulmonary pulmonary JJ cord-005453-4057qib7 10647 15 : : : cord-005453-4057qib7 10647 16 11 11 CD cord-005453-4057qib7 10647 17 , , , cord-005453-4057qib7 10647 18 urinary urinary JJ cord-005453-4057qib7 10647 19 : : : cord-005453-4057qib7 10647 20 03 03 CD cord-005453-4057qib7 10648 1 , , , cord-005453-4057qib7 10648 2 Oto Oto NNP cord-005453-4057qib7 10648 3 - - HYPH cord-005453-4057qib7 10648 4 Rhino Rhino NNP cord-005453-4057qib7 10648 5 - - HYPH cord-005453-4057qib7 10648 6 Laryngology Laryngology NNP cord-005453-4057qib7 10648 7 : : : cord-005453-4057qib7 10648 8 02 02 CD cord-005453-4057qib7 10648 9 ) ) -RRB- cord-005453-4057qib7 10648 10 . . . cord-005453-4057qib7 10649 1 The the DT cord-005453-4057qib7 10649 2 blood blood NN cord-005453-4057qib7 10649 3 cultures culture NNS cord-005453-4057qib7 10649 4 are be VBP cord-005453-4057qib7 10649 5 made make VBN cord-005453-4057qib7 10649 6 at at IN cord-005453-4057qib7 10649 7 195 195 CD cord-005453-4057qib7 10649 8 FE FE NNP cord-005453-4057qib7 10649 9 , , , cord-005453-4057qib7 10649 10 136 136 CD cord-005453-4057qib7 10649 11 FE FE NNP cord-005453-4057qib7 10649 12 are be VBP cord-005453-4057qib7 10649 13 microbiologically microbiologically RB cord-005453-4057qib7 10649 14 documented document VBN cord-005453-4057qib7 10649 15 ( ( -LRB- cord-005453-4057qib7 10649 16 66 66 CD cord-005453-4057qib7 10649 17 % % NN cord-005453-4057qib7 10649 18 ): ): NN cord-005453-4057qib7 10649 19 gram gram JJ cord-005453-4057qib7 10649 20 - - HYPH cord-005453-4057qib7 10649 21 positive positive JJ cord-005453-4057qib7 10649 22 bacteremia bacteremia NN cord-005453-4057qib7 10649 23 in in IN cord-005453-4057qib7 10649 24 77 77 CD cord-005453-4057qib7 10649 25 % % NN cord-005453-4057qib7 10649 26 ( ( -LRB- cord-005453-4057qib7 10649 27 mainly mainly RB cord-005453-4057qib7 10649 28 coagulase coagulase JJ cord-005453-4057qib7 10649 29 negative negative JJ cord-005453-4057qib7 10649 30 staphylococci staphylococcus NNS cord-005453-4057qib7 10649 31 ) ) -RRB- cord-005453-4057qib7 10649 32 and and CC cord-005453-4057qib7 10649 33 gramnegative gramnegative JJ cord-005453-4057qib7 10649 34 bacilli bacilli JJ cord-005453-4057qib7 10649 35 in in IN cord-005453-4057qib7 10649 36 23 23 CD cord-005453-4057qib7 10649 37 % % NN cord-005453-4057qib7 10649 38 of of IN cord-005453-4057qib7 10649 39 cases case NNS cord-005453-4057qib7 10649 40 . . . cord-005453-4057qib7 10650 1 Procalcitonin Procalcitonin NNP cord-005453-4057qib7 10650 2 test test NN cord-005453-4057qib7 10650 3 performed perform VBN cord-005453-4057qib7 10650 4 during during IN cord-005453-4057qib7 10650 5 157 157 CD cord-005453-4057qib7 10650 6 FE FE NNP cord-005453-4057qib7 10650 7 : : : cord-005453-4057qib7 10650 8 normal normal JJ cord-005453-4057qib7 10650 9 ( ( -LRB- cord-005453-4057qib7 10650 10 32 32 CD cord-005453-4057qib7 10650 11 cases case NNS cord-005453-4057qib7 10650 12 ) ) -RRB- cord-005453-4057qib7 10650 13 , , , cord-005453-4057qib7 10650 14 probable probable JJ cord-005453-4057qib7 10650 15 infection infection NN cord-005453-4057qib7 10650 16 ( ( -LRB- cord-005453-4057qib7 10650 17 90 90 CD cord-005453-4057qib7 10650 18 cases case NNS cord-005453-4057qib7 10650 19 ) ) -RRB- cord-005453-4057qib7 10650 20 , , , cord-005453-4057qib7 10650 21 probable probable JJ cord-005453-4057qib7 10650 22 sepsis sepsis NN cord-005453-4057qib7 10650 23 ( ( -LRB- cord-005453-4057qib7 10650 24 15 15 CD cord-005453-4057qib7 10650 25 cases case NNS cord-005453-4057qib7 10650 26 ) ) -RRB- cord-005453-4057qib7 10650 27 , , , cord-005453-4057qib7 10650 28 severe severe JJ cord-005453-4057qib7 10650 29 sepsis sepsis NN cord-005453-4057qib7 10650 30 ( ( -LRB- cord-005453-4057qib7 10650 31 19 19 CD cord-005453-4057qib7 10650 32 cases case NNS cord-005453-4057qib7 10650 33 ) ) -RRB- cord-005453-4057qib7 10650 34 and and CC cord-005453-4057qib7 10650 35 septic septic JJ cord-005453-4057qib7 10650 36 shock shock NN cord-005453-4057qib7 10650 37 ( ( -LRB- cord-005453-4057qib7 10650 38 one one CD cord-005453-4057qib7 10650 39 case case NN cord-005453-4057qib7 10650 40 ) ) -RRB- cord-005453-4057qib7 10650 41 . . . cord-005453-4057qib7 10651 1 Empirical empirical JJ cord-005453-4057qib7 10651 2 double double JJ cord-005453-4057qib7 10651 3 antibiotic antibiotic JJ cord-005453-4057qib7 10651 4 therapy therapy NN cord-005453-4057qib7 10651 5 is be VBZ cord-005453-4057qib7 10651 6 initiated initiate VBN cord-005453-4057qib7 10651 7 in in IN cord-005453-4057qib7 10651 8 120 120 CD cord-005453-4057qib7 10651 9 pts pt NNS cord-005453-4057qib7 10651 10 without without IN cord-005453-4057qib7 10651 11 waiting wait VBG cord-005453-4057qib7 10651 12 for for IN cord-005453-4057qib7 10651 13 the the DT cord-005453-4057qib7 10651 14 results result NNS cord-005453-4057qib7 10651 15 of of IN cord-005453-4057qib7 10651 16 the the DT cord-005453-4057qib7 10651 17 microbiological microbiological JJ cord-005453-4057qib7 10651 18 study study NN cord-005453-4057qib7 10651 19 . . . cord-005453-4057qib7 10652 1 This this DT cord-005453-4057qib7 10652 2 association association NN cord-005453-4057qib7 10652 3 was be VBD cord-005453-4057qib7 10652 4 sufficient sufficient JJ cord-005453-4057qib7 10652 5 in in IN cord-005453-4057qib7 10652 6 15 15 CD cord-005453-4057qib7 10652 7 pts pt NNS cord-005453-4057qib7 10652 8 ( ( -LRB- cord-005453-4057qib7 10652 9 11 11 CD cord-005453-4057qib7 10652 10 % % NN cord-005453-4057qib7 10652 11 ) ) -RRB- cord-005453-4057qib7 10652 12 . . . cord-005453-4057qib7 10653 1 The the DT cord-005453-4057qib7 10653 2 transition transition NN cord-005453-4057qib7 10653 3 to to IN cord-005453-4057qib7 10653 4 a a DT cord-005453-4057qib7 10653 5 second second JJ cord-005453-4057qib7 10653 6 line line NN cord-005453-4057qib7 10653 7 was be VBD cord-005453-4057qib7 10653 8 needed need VBN cord-005453-4057qib7 10653 9 in in IN cord-005453-4057qib7 10653 10 114 114 CD cord-005453-4057qib7 10653 11 pts pt NNS cord-005453-4057qib7 10653 12 ( ( -LRB- cord-005453-4057qib7 10653 13 83.8 83.8 CD cord-005453-4057qib7 10653 14 % % NN cord-005453-4057qib7 10653 15 ) ) -RRB- cord-005453-4057qib7 10653 16 and and CC cord-005453-4057qib7 10653 17 third third JJ cord-005453-4057qib7 10653 18 line line NN cord-005453-4057qib7 10653 19 in in IN cord-005453-4057qib7 10653 20 82 82 CD cord-005453-4057qib7 10653 21 pts pt NNS cord-005453-4057qib7 10653 22 ( ( -LRB- cord-005453-4057qib7 10653 23 60 60 CD cord-005453-4057qib7 10653 24 % % NN cord-005453-4057qib7 10653 25 ) ) -RRB- cord-005453-4057qib7 10653 26 . . . cord-005453-4057qib7 10654 1 Antifungal Antifungal NNP cord-005453-4057qib7 10654 2 is be VBZ cord-005453-4057qib7 10654 3 added add VBN cord-005453-4057qib7 10654 4 in in IN cord-005453-4057qib7 10654 5 36 36 CD cord-005453-4057qib7 10654 6 cases case NNS cord-005453-4057qib7 10654 7 ( ( -LRB- cord-005453-4057qib7 10654 8 27 27 CD cord-005453-4057qib7 10654 9 % % NN cord-005453-4057qib7 10654 10 ) ) -RRB- cord-005453-4057qib7 10654 11 . . . cord-005453-4057qib7 10655 1 Eight eight CD cord-005453-4057qib7 10655 2 pts pt NNS cord-005453-4057qib7 10655 3 benefited benefit VBN cord-005453-4057qib7 10655 4 from from IN cord-005453-4057qib7 10655 5 G G NNP cord-005453-4057qib7 10655 6 - - HYPH cord-005453-4057qib7 10655 7 CSF CSF NNP cord-005453-4057qib7 10655 8 . . . cord-005453-4057qib7 10656 1 The the DT cord-005453-4057qib7 10656 2 evolution evolution NN cord-005453-4057qib7 10656 3 is be VBZ cord-005453-4057qib7 10656 4 favorable favorable JJ cord-005453-4057qib7 10656 5 in in IN cord-005453-4057qib7 10656 6 202 202 CD cord-005453-4057qib7 10656 7 FE FE NNP cord-005453-4057qib7 10656 8 ( ( -LRB- cord-005453-4057qib7 10656 9 98.5 98.5 CD cord-005453-4057qib7 10656 10 % % NN cord-005453-4057qib7 10656 11 ) ) -RRB- cord-005453-4057qib7 10656 12 , , , cord-005453-4057qib7 10656 13 apyrexia apyrexia NNP cord-005453-4057qib7 10656 14 obtained obtain VBN cord-005453-4057qib7 10656 15 after after IN cord-005453-4057qib7 10656 16 an an DT cord-005453-4057qib7 10656 17 average average NN cord-005453-4057qib7 10656 18 of of IN cord-005453-4057qib7 10656 19 3.3 3.3 CD cord-005453-4057qib7 10656 20 days day NNS cord-005453-4057qib7 10656 21 . . . cord-005453-4057qib7 10657 1 Three three CD cord-005453-4057qib7 10657 2 pts pt NNS cord-005453-4057qib7 10657 3 died die VBD cord-005453-4057qib7 10657 4 ( ( -LRB- cord-005453-4057qib7 10657 5 2 2 CD cord-005453-4057qib7 10657 6 % % NN cord-005453-4057qib7 10657 7 ) ) -RRB- cord-005453-4057qib7 10657 8 by by IN cord-005453-4057qib7 10657 9 severe severe JJ cord-005453-4057qib7 10657 10 sepsis sepsis NN cord-005453-4057qib7 10657 11 on on IN cord-005453-4057qib7 10657 12 a a DT cord-005453-4057qib7 10657 13 durable durable JJ cord-005453-4057qib7 10657 14 aplasia aplasia NN cord-005453-4057qib7 10657 15 , , , cord-005453-4057qib7 10657 16 2 2 CD cord-005453-4057qib7 10657 17 of of IN cord-005453-4057qib7 10657 18 which which WDT cord-005453-4057qib7 10657 19 had have VBD cord-005453-4057qib7 10657 20 a a DT cord-005453-4057qib7 10657 21 cellulitis cellulitis NN cord-005453-4057qib7 10657 22 before before IN cord-005453-4057qib7 10657 23 the the DT cord-005453-4057qib7 10657 24 conditioning conditioning NN cord-005453-4057qib7 10657 25 . . . cord-005453-4057qib7 10658 1 Conclusions conclusion NNS cord-005453-4057qib7 10658 2 : : : cord-005453-4057qib7 10658 3 FE fe NN cord-005453-4057qib7 10658 4 increase increase NN cord-005453-4057qib7 10658 5 morbidity morbidity NN cord-005453-4057qib7 10658 6 and and CC cord-005453-4057qib7 10658 7 mortality mortality NN cord-005453-4057qib7 10658 8 in in IN cord-005453-4057qib7 10658 9 allo allo NN cord-005453-4057qib7 10658 10 - - HYPH cord-005453-4057qib7 10658 11 HSCT HSCT NNP cord-005453-4057qib7 10658 12 so so IN cord-005453-4057qib7 10658 13 prophylactic prophylactic JJ cord-005453-4057qib7 10658 14 measures measure NNS cord-005453-4057qib7 10658 15 are be VBP cord-005453-4057qib7 10658 16 essential essential JJ cord-005453-4057qib7 10658 17 . . . cord-005453-4057qib7 10659 1 Empirical empirical JJ cord-005453-4057qib7 10659 2 antibiotics antibiotic NNS cord-005453-4057qib7 10659 3 treatment treatment NN cord-005453-4057qib7 10659 4 has have VBZ cord-005453-4057qib7 10659 5 to to TO cord-005453-4057qib7 10659 6 be be VB cord-005453-4057qib7 10659 7 instituted institute VBN cord-005453-4057qib7 10659 8 very very RB cord-005453-4057qib7 10659 9 quickly quickly RB cord-005453-4057qib7 10659 10 in in IN cord-005453-4057qib7 10659 11 the the DT cord-005453-4057qib7 10659 12 absence absence NN cord-005453-4057qib7 10659 13 of of IN cord-005453-4057qib7 10659 14 documentation documentation NN cord-005453-4057qib7 10659 15 . . . cord-005453-4057qib7 10660 1 Disclosure disclosure NN cord-005453-4057qib7 10660 2 : : : cord-005453-4057qib7 10660 3 Nothing nothing NN cord-005453-4057qib7 10660 4 to to TO cord-005453-4057qib7 10660 5 declare declare VB cord-005453-4057qib7 10660 6 P472 P472 NNP cord-005453-4057qib7 10660 7 Abstract Abstract NNP cord-005453-4057qib7 10660 8 withdrawn withdraw VBN cord-005453-4057qib7 10660 9 . . . cord-005453-4057qib7 10661 1 Atsushi Atsushi NNP cord-005453-4057qib7 10661 2 Satake Satake NNP cord-005453-4057qib7 10661 3 1 1 CD cord-005453-4057qib7 10661 4 , , , cord-005453-4057qib7 10661 5 Masaaki Masaaki NNP cord-005453-4057qib7 10661 6 Hotta Hotta NNP cord-005453-4057qib7 10661 7 1 1 CD cord-005453-4057qib7 10661 8 , , , cord-005453-4057qib7 10661 9 Ryo Ryo NNP cord-005453-4057qib7 10661 10 Saito Saito NNP cord-005453-4057qib7 10661 11 1 1 CD cord-005453-4057qib7 10661 12 , , , cord-005453-4057qib7 10661 13 Akiko Akiko NNP cord-005453-4057qib7 10661 14 Konishi Konishi NNP cord-005453-4057qib7 10661 15 1 1 CD cord-005453-4057qib7 10661 16 , , , cord-005453-4057qib7 10661 17 Hideaki Hideaki NNP cord-005453-4057qib7 10661 18 Yoshimura Yoshimura NNP cord-005453-4057qib7 10661 19 1 1 CD cord-005453-4057qib7 10661 20 , , , cord-005453-4057qib7 10661 21 Takahisa Takahisa NNP cord-005453-4057qib7 10661 22 Nakanishi Nakanishi NNP cord-005453-4057qib7 10661 23 1 1 CD cord-005453-4057qib7 10661 24 , , , cord-005453-4057qib7 10661 25 Shinya Shinya NNP cord-005453-4057qib7 10661 26 Fujita Fujita NNP cord-005453-4057qib7 10661 27 1 1 CD cord-005453-4057qib7 10661 28 , , , cord-005453-4057qib7 10661 29 Tomoki Tomoki NNP cord-005453-4057qib7 10661 30 Ito Ito NNP cord-005453-4057qib7 10661 31 1 1 CD cord-005453-4057qib7 10661 32 , , , cord-005453-4057qib7 10661 33 Kazuyoshi Kazuyoshi NNP cord-005453-4057qib7 10661 34 Ishii Ishii NNP cord-005453-4057qib7 10661 35 1 1 CD cord-005453-4057qib7 10662 1 , , , cord-005453-4057qib7 10662 2 Shosaku Shosaku NNP cord-005453-4057qib7 10662 3 Nomura Nomura NNP cord-005453-4057qib7 10662 4 1 1 CD cord-005453-4057qib7 10662 5 1 1 CD cord-005453-4057qib7 10662 6 Kansai Kansai NNP cord-005453-4057qib7 10662 7 Medical Medical NNP cord-005453-4057qib7 10662 8 University University NNP cord-005453-4057qib7 10662 9 , , , cord-005453-4057qib7 10662 10 Osaka Osaka NNP cord-005453-4057qib7 10662 11 , , , cord-005453-4057qib7 10662 12 Japan Japan NNP cord-005453-4057qib7 10662 13 Background Background NNP cord-005453-4057qib7 10662 14 : : : cord-005453-4057qib7 10662 15 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 10662 16 ( ( -LRB- cord-005453-4057qib7 10662 17 CMV CMV NNP cord-005453-4057qib7 10662 18 ) ) -RRB- cord-005453-4057qib7 10662 19 infection infection NN cord-005453-4057qib7 10662 20 remains remain VBZ cord-005453-4057qib7 10662 21 a a DT cord-005453-4057qib7 10662 22 common common JJ cord-005453-4057qib7 10662 23 complication complication NN cord-005453-4057qib7 10662 24 after after IN cord-005453-4057qib7 10662 25 allogeneic allogeneic JJ cord-005453-4057qib7 10662 26 hematopoietic hematopoietic JJ cord-005453-4057qib7 10662 27 stem stem NN cord-005453-4057qib7 10662 28 cell cell NN cord-005453-4057qib7 10662 29 transplantation transplantation NN cord-005453-4057qib7 10662 30 ( ( -LRB- cord-005453-4057qib7 10662 31 aHSCT aHSCT NNP cord-005453-4057qib7 10662 32 ) ) -RRB- cord-005453-4057qib7 10662 33 , , , cord-005453-4057qib7 10662 34 which which WDT cord-005453-4057qib7 10662 35 results result VBZ cord-005453-4057qib7 10662 36 in in IN cord-005453-4057qib7 10662 37 increased increase VBN cord-005453-4057qib7 10662 38 morbidity morbidity NN cord-005453-4057qib7 10662 39 and and CC cord-005453-4057qib7 10662 40 mortality mortality NN cord-005453-4057qib7 10662 41 . . . cord-005453-4057qib7 10663 1 Letermovir Letermovir NNP cord-005453-4057qib7 10663 2 is be VBZ cord-005453-4057qib7 10663 3 a a DT cord-005453-4057qib7 10663 4 novel novel JJ cord-005453-4057qib7 10663 5 anti anti AFX cord-005453-4057qib7 10663 6 CMV CMV NNP cord-005453-4057qib7 10663 7 drug drug NN cord-005453-4057qib7 10663 8 that that WDT cord-005453-4057qib7 10663 9 inhibits inhibit VBZ cord-005453-4057qib7 10663 10 the the DT cord-005453-4057qib7 10663 11 CMV CMV NNP cord-005453-4057qib7 10663 12 - - HYPH cord-005453-4057qib7 10663 13 terminase terminase NN cord-005453-4057qib7 10663 14 complex complex NN cord-005453-4057qib7 10663 15 . . . cord-005453-4057qib7 10664 1 The the DT cord-005453-4057qib7 10664 2 purpose purpose NN cord-005453-4057qib7 10664 3 of of IN cord-005453-4057qib7 10664 4 this this DT cord-005453-4057qib7 10664 5 retrospective retrospective JJ cord-005453-4057qib7 10664 6 study study NN cord-005453-4057qib7 10664 7 is be VBZ cord-005453-4057qib7 10664 8 to to TO cord-005453-4057qib7 10664 9 elucidate elucidate VB cord-005453-4057qib7 10664 10 the the DT cord-005453-4057qib7 10664 11 efficacy efficacy NN cord-005453-4057qib7 10664 12 and and CC cord-005453-4057qib7 10664 13 safety safety NN cord-005453-4057qib7 10664 14 of of IN cord-005453-4057qib7 10664 15 CMV CMV NNP cord-005453-4057qib7 10664 16 prophylaxis prophylaxis NN cord-005453-4057qib7 10664 17 with with IN cord-005453-4057qib7 10664 18 letermovir letermovir NNS cord-005453-4057qib7 10664 19 early early RB cord-005453-4057qib7 10664 20 after after IN cord-005453-4057qib7 10664 21 aHSCT ahsct NN cord-005453-4057qib7 10664 22 in in IN cord-005453-4057qib7 10664 23 clinical clinical JJ cord-005453-4057qib7 10664 24 practice practice NN cord-005453-4057qib7 10664 25 . . . cord-005453-4057qib7 10665 1 Methods method NNS cord-005453-4057qib7 10665 2 : : : cord-005453-4057qib7 10665 3 We -PRON- PRP cord-005453-4057qib7 10665 4 retrospectively retrospectively RB cord-005453-4057qib7 10665 5 analyzed analyze VBD cord-005453-4057qib7 10665 6 the the DT cord-005453-4057qib7 10665 7 incidence incidence NN cord-005453-4057qib7 10665 8 of of IN cord-005453-4057qib7 10665 9 CMV CMV NNP cord-005453-4057qib7 10665 10 infection infection NN cord-005453-4057qib7 10665 11 , , , cord-005453-4057qib7 10665 12 CMV CMV NNP cord-005453-4057qib7 10665 13 disease disease NN cord-005453-4057qib7 10665 14 , , , cord-005453-4057qib7 10665 15 preemptive preemptive JJ cord-005453-4057qib7 10665 16 therapy therapy NN cord-005453-4057qib7 10665 17 , , , cord-005453-4057qib7 10665 18 adverse adverse JJ cord-005453-4057qib7 10665 19 events event NNS cord-005453-4057qib7 10665 20 through through IN cord-005453-4057qib7 10665 21 week week NN cord-005453-4057qib7 10665 22 14 14 CD cord-005453-4057qib7 10665 23 after after IN cord-005453-4057qib7 10665 24 aHSCT aHSCT NNP cord-005453-4057qib7 10665 25 , , , cord-005453-4057qib7 10665 26 the the DT cord-005453-4057qib7 10665 27 rates rate NNS cord-005453-4057qib7 10665 28 of of IN cord-005453-4057qib7 10665 29 engraftment engraftment NN cord-005453-4057qib7 10665 30 and and CC cord-005453-4057qib7 10665 31 overall overall JJ cord-005453-4057qib7 10665 32 survival survival NN cord-005453-4057qib7 10665 33 . . . cord-005453-4057qib7 10666 1 All all DT cord-005453-4057qib7 10666 2 patients patient NNS cord-005453-4057qib7 10666 3 underwent undergo VBD cord-005453-4057qib7 10666 4 aHSCT ahsct RB cord-005453-4057qib7 10666 5 in in IN cord-005453-4057qib7 10666 6 our -PRON- PRP$ cord-005453-4057qib7 10666 7 institution institution NN cord-005453-4057qib7 10666 8 for for IN cord-005453-4057qib7 10666 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 10666 10 malignancies malignancy NNS cord-005453-4057qib7 10666 11 between between IN cord-005453-4057qib7 10666 12 May May NNP cord-005453-4057qib7 10666 13 2018 2018 CD cord-005453-4057qib7 10666 14 and and CC cord-005453-4057qib7 10666 15 Nov Nov NNP cord-005453-4057qib7 10666 16 2018 2018 CD cord-005453-4057qib7 10666 17 . . . cord-005453-4057qib7 10667 1 Data datum NNS cord-005453-4057qib7 10667 2 collected collect VBN cord-005453-4057qib7 10667 3 in in IN cord-005453-4057qib7 10667 4 this this DT cord-005453-4057qib7 10667 5 study study NN cord-005453-4057qib7 10667 6 included include VBD cord-005453-4057qib7 10667 7 patient patient NN cord-005453-4057qib7 10667 8 's 's POS cord-005453-4057qib7 10667 9 characteristics characteristic NNS cord-005453-4057qib7 10667 10 such such JJ cord-005453-4057qib7 10667 11 as as IN cord-005453-4057qib7 10667 12 age age NN cord-005453-4057qib7 10667 13 , , , cord-005453-4057qib7 10667 14 sex sex NN cord-005453-4057qib7 10667 15 , , , cord-005453-4057qib7 10667 16 disease disease NN cord-005453-4057qib7 10667 17 status status NN cord-005453-4057qib7 10667 18 , , , cord-005453-4057qib7 10667 19 donor donor NN cord-005453-4057qib7 10667 20 source source NN cord-005453-4057qib7 10667 21 and and CC cord-005453-4057qib7 10667 22 CMV CMV NNP cord-005453-4057qib7 10667 23 disease disease NN cord-005453-4057qib7 10667 24 risk risk NN cord-005453-4057qib7 10667 25 . . . cord-005453-4057qib7 10668 1 CMV CMV NNP cord-005453-4057qib7 10668 2 infection infection NN cord-005453-4057qib7 10668 3 was be VBD cord-005453-4057qib7 10668 4 evaluated evaluate VBN cord-005453-4057qib7 10668 5 by by IN cord-005453-4057qib7 10668 6 CMV CMV NNP cord-005453-4057qib7 10668 7 antigenemia antigenemia NN cord-005453-4057qib7 10668 8 . . . cord-005453-4057qib7 10669 1 This this DT cord-005453-4057qib7 10669 2 study study NN cord-005453-4057qib7 10669 3 was be VBD cord-005453-4057qib7 10669 4 approved approve VBN cord-005453-4057qib7 10669 5 by by IN cord-005453-4057qib7 10669 6 the the DT cord-005453-4057qib7 10669 7 Research Research NNP cord-005453-4057qib7 10669 8 Ethics Ethics NNP cord-005453-4057qib7 10669 9 Committee Committee NNP cord-005453-4057qib7 10669 10 of of IN cord-005453-4057qib7 10669 11 the the DT cord-005453-4057qib7 10669 12 Faculty Faculty NNP cord-005453-4057qib7 10669 13 of of IN cord-005453-4057qib7 10669 14 Medicine Medicine NNP cord-005453-4057qib7 10669 15 , , , cord-005453-4057qib7 10669 16 Kansai Kansai NNP cord-005453-4057qib7 10669 17 Medical Medical NNP cord-005453-4057qib7 10669 18 University University NNP cord-005453-4057qib7 10669 19 . . . cord-005453-4057qib7 10670 1 Results result NNS cord-005453-4057qib7 10670 2 : : : cord-005453-4057qib7 10671 1 Thirteen thirteen CD cord-005453-4057qib7 10671 2 patients patient NNS cord-005453-4057qib7 10671 3 ( ( -LRB- cord-005453-4057qib7 10671 4 male male JJ cord-005453-4057qib7 10671 5 9 9 CD cord-005453-4057qib7 10671 6 , , , cord-005453-4057qib7 10671 7 female female JJ cord-005453-4057qib7 10671 8 4 4 CD cord-005453-4057qib7 10671 9 ) ) -RRB- cord-005453-4057qib7 10671 10 underwent undergo VBD cord-005453-4057qib7 10671 11 aHSCT ahsct NN cord-005453-4057qib7 10671 12 and and CC cord-005453-4057qib7 10671 13 received receive VBD cord-005453-4057qib7 10671 14 CMV CMV NNP cord-005453-4057qib7 10671 15 prophylaxis prophylaxis NN cord-005453-4057qib7 10671 16 with with IN cord-005453-4057qib7 10671 17 letermovir letermovir NNS cord-005453-4057qib7 10671 18 . . . cord-005453-4057qib7 10672 1 The the DT cord-005453-4057qib7 10672 2 median median JJ cord-005453-4057qib7 10672 3 age age NN cord-005453-4057qib7 10672 4 was be VBD cord-005453-4057qib7 10672 5 54 54 CD cord-005453-4057qib7 10672 6 years year NNS cord-005453-4057qib7 10672 7 ( ( -LRB- cord-005453-4057qib7 10672 8 range range NN cord-005453-4057qib7 10672 9 , , , cord-005453-4057qib7 10672 10 18 18 CD cord-005453-4057qib7 10672 11 - - SYM cord-005453-4057qib7 10672 12 65 65 CD cord-005453-4057qib7 10672 13 years year NNS cord-005453-4057qib7 10672 14 ) ) -RRB- cord-005453-4057qib7 10672 15 . . . cord-005453-4057qib7 10673 1 Overall overall RB cord-005453-4057qib7 10673 2 , , , cord-005453-4057qib7 10673 3 10 10 CD cord-005453-4057qib7 10673 4 of of IN cord-005453-4057qib7 10673 5 13 13 CD cord-005453-4057qib7 10673 6 patients patient NNS cord-005453-4057qib7 10673 7 ( ( -LRB- cord-005453-4057qib7 10673 8 76.9 76.9 CD cord-005453-4057qib7 10673 9 % % NN cord-005453-4057qib7 10673 10 ) ) -RRB- cord-005453-4057qib7 10673 11 were be VBD cord-005453-4057qib7 10673 12 considered consider VBN cord-005453-4057qib7 10673 13 to to TO cord-005453-4057qib7 10673 14 be be VB cord-005453-4057qib7 10673 15 at at IN cord-005453-4057qib7 10673 16 high high JJ cord-005453-4057qib7 10673 17 risk risk NN cord-005453-4057qib7 10673 18 for for IN cord-005453-4057qib7 10673 19 CMV CMV NNP cord-005453-4057qib7 10673 20 , , , cord-005453-4057qib7 10673 21 including include VBG cord-005453-4057qib7 10673 22 5 5 CD cord-005453-4057qib7 10673 23 patients patient NNS cord-005453-4057qib7 10673 24 ( ( -LRB- cord-005453-4057qib7 10673 25 38.5 38.5 CD cord-005453-4057qib7 10673 26 % % NN cord-005453-4057qib7 10673 27 ) ) -RRB- cord-005453-4057qib7 10673 28 with with IN cord-005453-4057qib7 10673 29 haploidentical haploidentical JJ cord-005453-4057qib7 10673 30 donors donor NNS cord-005453-4057qib7 10673 31 , , , cord-005453-4057qib7 10673 32 and and CC cord-005453-4057qib7 10673 33 1 1 CD cord-005453-4057qib7 10673 34 ( ( -LRB- cord-005453-4057qib7 10673 35 7.7 7.7 CD cord-005453-4057qib7 10673 36 % % NN cord-005453-4057qib7 10673 37 ) ) -RRB- cord-005453-4057qib7 10673 38 with with IN cord-005453-4057qib7 10673 39 mismatched mismatched JJ cord-005453-4057qib7 10673 40 , , , cord-005453-4057qib7 10673 41 unrelated unrelated JJ cord-005453-4057qib7 10673 42 donors donor NNS cord-005453-4057qib7 10673 43 . . . cord-005453-4057qib7 10674 1 All all DT cord-005453-4057qib7 10674 2 patients patient NNS cord-005453-4057qib7 10674 3 began begin VBD cord-005453-4057qib7 10674 4 letermovir letermovir NNS cord-005453-4057qib7 10674 5 from from IN cord-005453-4057qib7 10674 6 day day NN cord-005453-4057qib7 10674 7 0 0 CD cord-005453-4057qib7 10674 8 after after IN cord-005453-4057qib7 10674 9 aHSCT ahsct NN cord-005453-4057qib7 10674 10 , , , cord-005453-4057qib7 10674 11 and and CC cord-005453-4057qib7 10674 12 achieved achieve VBN cord-005453-4057qib7 10674 13 engraftment engraftment NNP cord-005453-4057qib7 10674 14 ( ( -LRB- cord-005453-4057qib7 10674 15 median median NNP cord-005453-4057qib7 10674 16 17 17 CD cord-005453-4057qib7 10674 17 , , , cord-005453-4057qib7 10674 18 13 13 CD cord-005453-4057qib7 10674 19 - - SYM cord-005453-4057qib7 10674 20 22 22 CD cord-005453-4057qib7 10674 21 days day NNS cord-005453-4057qib7 10674 22 ) ) -RRB- cord-005453-4057qib7 10674 23 . . . cord-005453-4057qib7 10675 1 No no DT cord-005453-4057qib7 10675 2 patient patient NN cord-005453-4057qib7 10675 3 developed develop VBD cord-005453-4057qib7 10675 4 CMV CMV NNP cord-005453-4057qib7 10675 5 disease disease NN cord-005453-4057qib7 10675 6 and and CC cord-005453-4057qib7 10675 7 required require VBN cord-005453-4057qib7 10675 8 preemptive preemptive JJ cord-005453-4057qib7 10675 9 therapy therapy NN cord-005453-4057qib7 10675 10 . . . cord-005453-4057qib7 10676 1 One one CD cord-005453-4057qib7 10676 2 patient patient NN cord-005453-4057qib7 10676 3 died die VBD cord-005453-4057qib7 10676 4 of of IN cord-005453-4057qib7 10676 5 treatment treatment NN cord-005453-4057qib7 10676 6 - - HYPH cord-005453-4057qib7 10676 7 related relate VBN cord-005453-4057qib7 10676 8 mortality mortality NN cord-005453-4057qib7 10676 9 , , , cord-005453-4057qib7 10676 10 and and CC cord-005453-4057qib7 10676 11 2 2 CD cord-005453-4057qib7 10676 12 patients patient NNS cord-005453-4057qib7 10676 13 died die VBD cord-005453-4057qib7 10676 14 of of IN cord-005453-4057qib7 10676 15 acute acute JJ cord-005453-4057qib7 10676 16 GVHD GVHD NNP cord-005453-4057qib7 10676 17 . . . cord-005453-4057qib7 10677 1 Although although IN cord-005453-4057qib7 10677 2 one one CD cord-005453-4057qib7 10677 3 patient patient NN cord-005453-4057qib7 10677 4 discontinued discontinue VBD cord-005453-4057qib7 10677 5 letermovir letermovir NNS cord-005453-4057qib7 10677 6 before before IN cord-005453-4057qib7 10677 7 day day NN cord-005453-4057qib7 10677 8 100 100 CD cord-005453-4057qib7 10677 9 after after IN cord-005453-4057qib7 10677 10 aHSCT aHSCT NNP cord-005453-4057qib7 10677 11 because because IN cord-005453-4057qib7 10677 12 letermovir letermovir NNP cord-005453-4057qib7 10677 13 was be VBD cord-005453-4057qib7 10677 14 suspected suspect VBN cord-005453-4057qib7 10677 15 to to TO cord-005453-4057qib7 10677 16 be be VB cord-005453-4057qib7 10677 17 a a DT cord-005453-4057qib7 10677 18 cause cause NN cord-005453-4057qib7 10677 19 of of IN cord-005453-4057qib7 10677 20 persistent persistent JJ cord-005453-4057qib7 10677 21 nausea nausea NN cord-005453-4057qib7 10677 22 , , , cord-005453-4057qib7 10677 23 severe severe JJ cord-005453-4057qib7 10677 24 adverse adverse JJ cord-005453-4057qib7 10677 25 events event NNS cord-005453-4057qib7 10677 26 were be VBD cord-005453-4057qib7 10677 27 not not RB cord-005453-4057qib7 10677 28 observed observe VBN cord-005453-4057qib7 10677 29 . . . cord-005453-4057qib7 10678 1 Conclusions conclusion NNS cord-005453-4057qib7 10678 2 : : : cord-005453-4057qib7 10679 1 It -PRON- PRP cord-005453-4057qib7 10679 2 is be VBZ cord-005453-4057qib7 10679 3 still still RB cord-005453-4057qib7 10679 4 unknown unknown JJ cord-005453-4057qib7 10679 5 whether whether IN cord-005453-4057qib7 10679 6 CMV CMV NNP cord-005453-4057qib7 10679 7 prophylaxis prophylaxis NN cord-005453-4057qib7 10679 8 with with IN cord-005453-4057qib7 10679 9 letermovir letermovir NNP cord-005453-4057qib7 10679 10 improves improve VBZ cord-005453-4057qib7 10679 11 OS OS NNP cord-005453-4057qib7 10679 12 and and CC cord-005453-4057qib7 10679 13 reduces reduce VBZ cord-005453-4057qib7 10679 14 TRM TRM NNP cord-005453-4057qib7 10679 15 ; ; : cord-005453-4057qib7 10679 16 however however RB cord-005453-4057qib7 10679 17 , , , cord-005453-4057qib7 10679 18 our -PRON- PRP$ cord-005453-4057qib7 10679 19 data datum NNS cord-005453-4057qib7 10679 20 suggests suggest VBZ cord-005453-4057qib7 10679 21 that that IN cord-005453-4057qib7 10679 22 CMV CMV NNP cord-005453-4057qib7 10679 23 infection infection NN cord-005453-4057qib7 10679 24 is be VBZ cord-005453-4057qib7 10679 25 considerably considerably RB cord-005453-4057qib7 10679 26 inhibited inhibit VBN cord-005453-4057qib7 10679 27 by by IN cord-005453-4057qib7 10679 28 administration administration NN cord-005453-4057qib7 10679 29 of of IN cord-005453-4057qib7 10679 30 letermovir letermovir NNP cord-005453-4057qib7 10679 31 early early RB cord-005453-4057qib7 10679 32 after after IN cord-005453-4057qib7 10679 33 aHSCT ahsct NN cord-005453-4057qib7 10679 34 . . . cord-005453-4057qib7 10680 1 Clinical clinical JJ cord-005453-4057qib7 10680 2 Trial Trial NNP cord-005453-4057qib7 10680 3 Registry Registry NNP cord-005453-4057qib7 10680 4 : : : cord-005453-4057qib7 10681 1 Not not RB cord-005453-4057qib7 10681 2 applicable applicable JJ cord-005453-4057qib7 10681 3 . . . cord-005453-4057qib7 10682 1 Disclosure disclosure NN cord-005453-4057qib7 10682 2 : : : cord-005453-4057qib7 10683 1 The the DT cord-005453-4057qib7 10683 2 authors author NNS cord-005453-4057qib7 10683 3 declare declare VBP cord-005453-4057qib7 10683 4 noconflicts noconflict NNS cord-005453-4057qib7 10683 5 of of IN cord-005453-4057qib7 10683 6 interest interest NN cord-005453-4057qib7 10683 7 for for IN cord-005453-4057qib7 10683 8 this this DT cord-005453-4057qib7 10683 9 study study NN cord-005453-4057qib7 10683 10 . . . cord-005453-4057qib7 10684 1 Background background NN cord-005453-4057qib7 10684 2 : : : cord-005453-4057qib7 10684 3 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 10684 4 ( ( -LRB- cord-005453-4057qib7 10684 5 CMV CMV NNP cord-005453-4057qib7 10684 6 ) ) -RRB- cord-005453-4057qib7 10684 7 is be VBZ cord-005453-4057qib7 10684 8 cause cause NN cord-005453-4057qib7 10684 9 of of IN cord-005453-4057qib7 10684 10 increased increase VBN cord-005453-4057qib7 10684 11 morbidity morbidity NN cord-005453-4057qib7 10684 12 and and CC cord-005453-4057qib7 10684 13 mortality mortality NN cord-005453-4057qib7 10684 14 after after IN cord-005453-4057qib7 10684 15 transplantation transplantation NN cord-005453-4057qib7 10684 16 of of IN cord-005453-4057qib7 10684 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 10684 18 cells cell NNS cord-005453-4057qib7 10684 19 . . . cord-005453-4057qib7 10685 1 The the DT cord-005453-4057qib7 10685 2 pathogenesis pathogenesis NN cord-005453-4057qib7 10685 3 of of IN cord-005453-4057qib7 10685 4 CMV CMV NNP cord-005453-4057qib7 10685 5 disease disease NN cord-005453-4057qib7 10685 6 or or CC cord-005453-4057qib7 10685 7 infection infection NN cord-005453-4057qib7 10685 8 is be VBZ cord-005453-4057qib7 10685 9 complex complex JJ cord-005453-4057qib7 10685 10 with with IN cord-005453-4057qib7 10685 11 multiple multiple JJ cord-005453-4057qib7 10685 12 interactions interaction NNS cord-005453-4057qib7 10685 13 with with IN cord-005453-4057qib7 10685 14 the the DT cord-005453-4057qib7 10685 15 immune immune JJ cord-005453-4057qib7 10685 16 system system NN cord-005453-4057qib7 10685 17 , , , cord-005453-4057qib7 10685 18 mainly mainly RB cord-005453-4057qib7 10685 19 in in IN cord-005453-4057qib7 10685 20 acute acute JJ cord-005453-4057qib7 10685 21 and and CC cord-005453-4057qib7 10685 22 chronic chronic JJ cord-005453-4057qib7 10685 23 graft graft NN cord-005453-4057qib7 10685 24 - - HYPH cord-005453-4057qib7 10685 25 versus versus IN cord-005453-4057qib7 10685 26 - - HYPH cord-005453-4057qib7 10685 27 host host NN cord-005453-4057qib7 10685 28 disease disease NN cord-005453-4057qib7 10685 29 ( ( -LRB- cord-005453-4057qib7 10685 30 GVHD GVHD NNP cord-005453-4057qib7 10685 31 ) ) -RRB- cord-005453-4057qib7 10685 32 . . . cord-005453-4057qib7 10686 1 The the DT cord-005453-4057qib7 10686 2 aim aim NN cord-005453-4057qib7 10686 3 of of IN cord-005453-4057qib7 10686 4 this this DT cord-005453-4057qib7 10686 5 study study NN cord-005453-4057qib7 10686 6 is be VBZ cord-005453-4057qib7 10686 7 to to TO cord-005453-4057qib7 10686 8 analyze analyze VB cord-005453-4057qib7 10686 9 the the DT cord-005453-4057qib7 10686 10 risk risk NN cord-005453-4057qib7 10686 11 factors factor NNS cord-005453-4057qib7 10686 12 for for IN cord-005453-4057qib7 10686 13 the the DT cord-005453-4057qib7 10686 14 reactivation reactivation NN cord-005453-4057qib7 10686 15 of of IN cord-005453-4057qib7 10686 16 CMV CMV NNP cord-005453-4057qib7 10686 17 in in IN cord-005453-4057qib7 10686 18 patients patient NNS cord-005453-4057qib7 10686 19 undergoing undergo VBG cord-005453-4057qib7 10686 20 allogeneic allogeneic IN cord-005453-4057qib7 10686 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 10686 22 cell cell NN cord-005453-4057qib7 10686 23 transplantation transplantation NN cord-005453-4057qib7 10686 24 ( ( -LRB- cord-005453-4057qib7 10686 25 HCT HCT NNP cord-005453-4057qib7 10686 26 ) ) -RRB- cord-005453-4057qib7 10686 27 . . . cord-005453-4057qib7 10687 1 Methods method NNS cord-005453-4057qib7 10687 2 : : : cord-005453-4057qib7 10687 3 Prospective prospective JJ cord-005453-4057qib7 10687 4 descriptive descriptive JJ cord-005453-4057qib7 10687 5 study study NN cord-005453-4057qib7 10687 6 of of IN cord-005453-4057qib7 10687 7 the the DT cord-005453-4057qib7 10687 8 risk risk NN cord-005453-4057qib7 10687 9 factors factor NNS cord-005453-4057qib7 10687 10 for for IN cord-005453-4057qib7 10687 11 the the DT cord-005453-4057qib7 10687 12 reactivation reactivation NN cord-005453-4057qib7 10687 13 of of IN cord-005453-4057qib7 10687 14 CMV CMV NNP cord-005453-4057qib7 10687 15 in in IN cord-005453-4057qib7 10687 16 the the DT cord-005453-4057qib7 10687 17 described describe VBN cord-005453-4057qib7 10687 18 population population NN cord-005453-4057qib7 10687 19 . . . cord-005453-4057qib7 10688 1 Univariate univariate JJ cord-005453-4057qib7 10688 2 and and CC cord-005453-4057qib7 10688 3 multivariate multivariate JJ cord-005453-4057qib7 10688 4 analysis analysis NN cord-005453-4057qib7 10688 5 of of IN cord-005453-4057qib7 10688 6 the the DT cord-005453-4057qib7 10688 7 predisposing predisposing JJ cord-005453-4057qib7 10688 8 factors factor NNS cord-005453-4057qib7 10688 9 were be VBD cord-005453-4057qib7 10688 10 performed perform VBN cord-005453-4057qib7 10688 11 : : : cord-005453-4057qib7 10688 12 donor donor NN cord-005453-4057qib7 10688 13 graft graft NN cord-005453-4057qib7 10688 14 , , , cord-005453-4057qib7 10688 15 treatment treatment NN cord-005453-4057qib7 10688 16 with with IN cord-005453-4057qib7 10688 17 corticosteroids corticosteroid NNS cord-005453-4057qib7 10688 18 , , , cord-005453-4057qib7 10688 19 use use NN cord-005453-4057qib7 10688 20 of of IN cord-005453-4057qib7 10688 21 antithymoglobin antithymoglobin NN cord-005453-4057qib7 10688 22 , , , cord-005453-4057qib7 10688 23 serologic serologic NN cord-005453-4057qib7 10688 24 status status NN cord-005453-4057qib7 10688 25 , , , cord-005453-4057qib7 10688 26 conditioning conditioning NN cord-005453-4057qib7 10688 27 regimen regimen NN cord-005453-4057qib7 10688 28 and and CC cord-005453-4057qib7 10688 29 the the DT cord-005453-4057qib7 10688 30 presence presence NN cord-005453-4057qib7 10688 31 of of IN cord-005453-4057qib7 10688 32 GVHD GVHD NNP cord-005453-4057qib7 10688 33 . . . cord-005453-4057qib7 10689 1 Results result NNS cord-005453-4057qib7 10689 2 : : : cord-005453-4057qib7 10690 1 During during IN cord-005453-4057qib7 10690 2 the the DT cord-005453-4057qib7 10690 3 period period NN cord-005453-4057qib7 10690 4 between between IN cord-005453-4057qib7 10690 5 August August NNP cord-005453-4057qib7 10690 6 2014 2014 CD cord-005453-4057qib7 10690 7 until until IN cord-005453-4057qib7 10690 8 January January NNP cord-005453-4057qib7 10690 9 2017 2017 CD cord-005453-4057qib7 10690 10 , , , cord-005453-4057qib7 10690 11 71 71 CD cord-005453-4057qib7 10690 12 patients patient NNS cord-005453-4057qib7 10690 13 were be VBD cord-005453-4057qib7 10690 14 evaluated evaluate VBN cord-005453-4057qib7 10690 15 . . . cord-005453-4057qib7 10691 1 42.25 42.25 CD cord-005453-4057qib7 10691 2 % % NN cord-005453-4057qib7 10691 3 ( ( -LRB- cord-005453-4057qib7 10691 4 n:30 n:30 CD cord-005453-4057qib7 10691 5 ) ) -RRB- cord-005453-4057qib7 10691 6 had have VBD cord-005453-4057qib7 10691 7 reactivation reactivation NN cord-005453-4057qib7 10691 8 of of IN cord-005453-4057qib7 10691 9 CMV CMV NNP cord-005453-4057qib7 10691 10 . . . cord-005453-4057qib7 10692 1 Average average JJ cord-005453-4057qib7 10692 2 reactivation reactivation NN cord-005453-4057qib7 10692 3 was be VBD cord-005453-4057qib7 10692 4 58 58 CD cord-005453-4057qib7 10692 5 days day NNS cord-005453-4057qib7 10692 6 post post NN cord-005453-4057qib7 10692 7 transplant transplant NN cord-005453-4057qib7 10692 8 . . . cord-005453-4057qib7 10693 1 Both both DT cord-005453-4057qib7 10693 2 ( ( -LRB- cord-005453-4057qib7 10693 3 recipient recipient NN cord-005453-4057qib7 10693 4 and and CC cord-005453-4057qib7 10693 5 the the DT cord-005453-4057qib7 10693 6 donor donor NN cord-005453-4057qib7 10693 7 ) ) -RRB- cord-005453-4057qib7 10693 8 had have VBD cord-005453-4057qib7 10693 9 positive positive JJ cord-005453-4057qib7 10693 10 CMV CMV NNP cord-005453-4057qib7 10693 11 IgG igg NN cord-005453-4057qib7 10693 12 in in IN cord-005453-4057qib7 10693 13 78.9 78.9 CD cord-005453-4057qib7 10693 14 % % NN cord-005453-4057qib7 10693 15 . . . cord-005453-4057qib7 10694 1 In in IN cord-005453-4057qib7 10694 2 the the DT cord-005453-4057qib7 10694 3 univariate univariate JJ cord-005453-4057qib7 10694 4 analysis analysis NN cord-005453-4057qib7 10694 5 , , , cord-005453-4057qib7 10694 6 the the DT cord-005453-4057qib7 10694 7 reactivation reactivation NN cord-005453-4057qib7 10694 8 of of IN cord-005453-4057qib7 10694 9 CMV CMV NNP cord-005453-4057qib7 10694 10 was be VBD cord-005453-4057qib7 10694 11 associated associate VBN cord-005453-4057qib7 10694 12 with with IN cord-005453-4057qib7 10694 13 haploidentical haploidentical JJ cord-005453-4057qib7 10694 14 transplantation transplantation NN cord-005453-4057qib7 10694 15 ( ( -LRB- cord-005453-4057qib7 10694 16 p p NN cord-005453-4057qib7 10694 17 : : : cord-005453-4057qib7 10694 18 < < XX cord-005453-4057qib7 10694 19 0.01 0.01 CD cord-005453-4057qib7 10694 20 ) ) -RRB- cord-005453-4057qib7 10694 21 , , , cord-005453-4057qib7 10694 22 with with IN cord-005453-4057qib7 10694 23 the the DT cord-005453-4057qib7 10694 24 use use NN cord-005453-4057qib7 10694 25 of of IN cord-005453-4057qib7 10694 26 corticosteroids corticosteroid NNS cord-005453-4057qib7 10694 27 ( ( -LRB- cord-005453-4057qib7 10694 28 p p NN cord-005453-4057qib7 10694 29 : : : cord-005453-4057qib7 10694 30 < < XX cord-005453-4057qib7 10694 31 0.01 0.01 CD cord-005453-4057qib7 10694 32 ) ) -RRB- cord-005453-4057qib7 10694 33 and and CC cord-005453-4057qib7 10694 34 GVHD GVHD NNP cord-005453-4057qib7 10694 35 ( ( -LRB- cord-005453-4057qib7 10694 36 p p NN cord-005453-4057qib7 10694 37 : : : cord-005453-4057qib7 10694 38 < < XX cord-005453-4057qib7 10694 39 0.01 0.01 CD cord-005453-4057qib7 10694 40 ) ) -RRB- cord-005453-4057qib7 10694 41 . . . cord-005453-4057qib7 10695 1 In in IN cord-005453-4057qib7 10695 2 the the DT cord-005453-4057qib7 10695 3 multivariate multivariate JJ cord-005453-4057qib7 10695 4 analysis analysis NN cord-005453-4057qib7 10695 5 , , , cord-005453-4057qib7 10695 6 the the DT cord-005453-4057qib7 10695 7 haploidentical haploidentical JJ cord-005453-4057qib7 10695 8 transplant transplant NN cord-005453-4057qib7 10695 9 maintained maintain VBD cord-005453-4057qib7 10695 10 its -PRON- PRP$ cord-005453-4057qib7 10695 11 statistical statistical JJ cord-005453-4057qib7 10695 12 significance significance NN cord-005453-4057qib7 10695 13 in in IN cord-005453-4057qib7 10695 14 comparison comparison NN cord-005453-4057qib7 10695 15 with with IN cord-005453-4057qib7 10695 16 the the DT cord-005453-4057qib7 10695 17 related relate VBN cord-005453-4057qib7 10695 18 allogeneic allogeneic NN cord-005453-4057qib7 10695 19 transplant transplant NN cord-005453-4057qib7 10695 20 ( ( -LRB- cord-005453-4057qib7 10695 21 p p NN cord-005453-4057qib7 10695 22 : : : cord-005453-4057qib7 10695 23 0.0012 0.0012 CD cord-005453-4057qib7 10695 24 , , , cord-005453-4057qib7 10695 25 OR:7.07 OR:7.07 NNP cord-005453-4057qib7 10695 26 ; ; : cord-005453-4057qib7 10695 27 IC95%:2.4 IC95%:2.4 NNPS cord-005453-4057qib7 10695 28 - - HYPH cord-005453-4057qib7 10695 29 20.6 20.6 CD cord-005453-4057qib7 10695 30 ) ) -RRB- cord-005453-4057qib7 10695 31 as as RB cord-005453-4057qib7 10695 32 well well RB cord-005453-4057qib7 10695 33 as as IN cord-005453-4057qib7 10695 34 the the DT cord-005453-4057qib7 10695 35 use use NN cord-005453-4057qib7 10695 36 of of IN cord-005453-4057qib7 10695 37 corticosteroids corticosteroid NNS cord-005453-4057qib7 10695 38 ( ( -LRB- cord-005453-4057qib7 10695 39 p p NN cord-005453-4057qib7 10695 40 : : : cord-005453-4057qib7 10695 41 0.0014 0.0014 CD cord-005453-4057qib7 10695 42 , , , cord-005453-4057qib7 10695 43 OR:9.25 OR:9.25 NNP cord-005453-4057qib7 10695 44 ; ; : cord-005453-4057qib7 10695 45 IC95%:2.6 ic95%:2.6 CD cord-005453-4057qib7 10695 46 - - SYM cord-005453-4057qib7 10695 47 32.4 32.4 CD cord-005453-4057qib7 10695 48 ) ) -RRB- cord-005453-4057qib7 10695 49 . . . cord-005453-4057qib7 10696 1 100 100 CD cord-005453-4057qib7 10696 2 % % NN cord-005453-4057qib7 10696 3 of of IN cord-005453-4057qib7 10696 4 patients patient NNS cord-005453-4057qib7 10696 5 receiving receive VBG cord-005453-4057qib7 10696 6 corticosteroid corticosteroid JJ cord-005453-4057qib7 10696 7 treatment treatment NN cord-005453-4057qib7 10696 8 had have VBD cord-005453-4057qib7 10696 9 grade grade NN cord-005453-4057qib7 10696 10 II II NNP cord-005453-4057qib7 10696 11 / / SYM cord-005453-4057qib7 10696 12 III iii CD cord-005453-4057qib7 10696 13 GVHD GVHD NNP cord-005453-4057qib7 10696 14 . . . cord-005453-4057qib7 10697 1 The the DT cord-005453-4057qib7 10697 2 serologicac serologicac NN cord-005453-4057qib7 10697 3 status status NN cord-005453-4057qib7 10697 4 , , , cord-005453-4057qib7 10697 5 myeloablative myeloablative NNP cord-005453-4057qib7 10697 6 conditioning conditioning NN cord-005453-4057qib7 10697 7 regimen regimen NN cord-005453-4057qib7 10697 8 and and CC cord-005453-4057qib7 10697 9 the the DT cord-005453-4057qib7 10697 10 use use NN cord-005453-4057qib7 10697 11 of of IN cord-005453-4057qib7 10697 12 ATG ATG NNP cord-005453-4057qib7 10697 13 showed show VBD cord-005453-4057qib7 10697 14 no no DT cord-005453-4057qib7 10697 15 statistically statistically RB cord-005453-4057qib7 10697 16 significant significant JJ cord-005453-4057qib7 10697 17 association association NN cord-005453-4057qib7 10697 18 . . . cord-005453-4057qib7 10698 1 Conclusions conclusion NNS cord-005453-4057qib7 10698 2 : : : cord-005453-4057qib7 10699 1 In in IN cord-005453-4057qib7 10699 2 patients patient NNS cord-005453-4057qib7 10699 3 undergoing undergo VBG cord-005453-4057qib7 10699 4 allogeneic allogeneic IN cord-005453-4057qib7 10699 5 transplantation transplantation NN cord-005453-4057qib7 10699 6 , , , cord-005453-4057qib7 10699 7 were be VBD cord-005453-4057qib7 10699 8 found find VBN cord-005453-4057qib7 10699 9 as as IN cord-005453-4057qib7 10699 10 risk risk NN cord-005453-4057qib7 10699 11 factor factor NN cord-005453-4057qib7 10699 12 to to IN cord-005453-4057qib7 10699 13 reactivation reactivation NN cord-005453-4057qib7 10699 14 , , , cord-005453-4057qib7 10699 15 those those DT cord-005453-4057qib7 10699 16 who who WP cord-005453-4057qib7 10699 17 received receive VBD cord-005453-4057qib7 10699 18 haploidentic haploidentic JJ cord-005453-4057qib7 10699 19 transplantation transplantation NN cord-005453-4057qib7 10699 20 and and CC cord-005453-4057qib7 10699 21 treatment treatment NN cord-005453-4057qib7 10699 22 with with IN cord-005453-4057qib7 10699 23 corticosteroids corticosteroid NNS cord-005453-4057qib7 10699 24 . . . cord-005453-4057qib7 10700 1 Another another DT cord-005453-4057qib7 10700 2 risk risk NN cord-005453-4057qib7 10700 3 factor factor NN cord-005453-4057qib7 10700 4 that that WDT cord-005453-4057qib7 10700 5 showed show VBD cord-005453-4057qib7 10700 6 greater great JJR cord-005453-4057qib7 10700 7 reactivation reactivation NN cord-005453-4057qib7 10700 8 was be VBD cord-005453-4057qib7 10700 9 the the DT cord-005453-4057qib7 10700 10 presence presence NN cord-005453-4057qib7 10700 11 of of IN cord-005453-4057qib7 10700 12 GVHD GVHD NNP cord-005453-4057qib7 10700 13 . . . cord-005453-4057qib7 10701 1 Disclosure disclosure NN cord-005453-4057qib7 10701 2 : : : cord-005453-4057qib7 10701 3 nothing nothing NN cord-005453-4057qib7 10701 4 to to TO cord-005453-4057qib7 10701 5 declare declare VB cord-005453-4057qib7 10701 6 Methods method NNS cord-005453-4057qib7 10701 7 : : : cord-005453-4057qib7 10702 1 A a DT cord-005453-4057qib7 10702 2 37 37 CD cord-005453-4057qib7 10702 3 y y NN cord-005453-4057qib7 10702 4 / / SYM cord-005453-4057qib7 10702 5 o o NN cord-005453-4057qib7 10702 6 male male NN cord-005453-4057qib7 10702 7 was be VBD cord-005453-4057qib7 10702 8 referred refer VBN cord-005453-4057qib7 10702 9 for for IN cord-005453-4057qib7 10702 10 allogeneic allogeneic NN cord-005453-4057qib7 10702 11 transplant transplant NN cord-005453-4057qib7 10702 12 following follow VBG cord-005453-4057qib7 10702 13 3 3 CD cord-005453-4057qib7 10702 14 cycles cycle NNS cord-005453-4057qib7 10702 15 of of IN cord-005453-4057qib7 10702 16 induction induction NN cord-005453-4057qib7 10702 17 therapy therapy NN cord-005453-4057qib7 10702 18 for for IN cord-005453-4057qib7 10702 19 AML AML NNP cord-005453-4057qib7 10702 20 with with IN cord-005453-4057qib7 10702 21 complex complex JJ cord-005453-4057qib7 10702 22 karyotype karyotype NN cord-005453-4057qib7 10702 23 and and CC cord-005453-4057qib7 10702 24 AXSL1 axsl1 NN cord-005453-4057qib7 10702 25 mutation mutation NN cord-005453-4057qib7 10702 26 having have VBG cord-005453-4057qib7 10702 27 achieved achieve VBN cord-005453-4057qib7 10702 28 complete complete JJ cord-005453-4057qib7 10702 29 remission remission NN cord-005453-4057qib7 10702 30 following follow VBG cord-005453-4057qib7 10702 31 the the DT cord-005453-4057qib7 10702 32 first first JJ cord-005453-4057qib7 10702 33 cycle cycle NN cord-005453-4057qib7 10702 34 of of IN cord-005453-4057qib7 10702 35 chemotherapy chemotherapy NN cord-005453-4057qib7 10702 36 . . . cord-005453-4057qib7 10703 1 His -PRON- PRP$ cord-005453-4057qib7 10703 2 first first JJ cord-005453-4057qib7 10703 3 induction induction NN cord-005453-4057qib7 10703 4 cycle cycle NN cord-005453-4057qib7 10703 5 was be VBD cord-005453-4057qib7 10703 6 complicated complicate VBN cord-005453-4057qib7 10703 7 by by IN cord-005453-4057qib7 10703 8 a a DT cord-005453-4057qib7 10703 9 perianal perianal JJ cord-005453-4057qib7 10703 10 myeloid myeloid JJ cord-005453-4057qib7 10703 11 sarcoma sarcoma NN cord-005453-4057qib7 10703 12 which which WDT cord-005453-4057qib7 10703 13 became become VBD cord-005453-4057qib7 10703 14 infected infected JJ cord-005453-4057qib7 10703 15 and and CC cord-005453-4057qib7 10703 16 required require VBN cord-005453-4057qib7 10703 17 surgical surgical JJ cord-005453-4057qib7 10703 18 drainage drainage NN cord-005453-4057qib7 10703 19 and and CC cord-005453-4057qib7 10703 20 formation formation NN cord-005453-4057qib7 10703 21 of of IN cord-005453-4057qib7 10703 22 a a DT cord-005453-4057qib7 10703 23 defunctioning defunctione VBG cord-005453-4057qib7 10703 24 colostomy colostomy NN cord-005453-4057qib7 10703 25 . . . cord-005453-4057qib7 10704 1 Results result NNS cord-005453-4057qib7 10704 2 : : : cord-005453-4057qib7 10705 1 Following follow VBG cord-005453-4057qib7 10705 2 2 2 CD cord-005453-4057qib7 10705 3 allogeneic allogeneic NN cord-005453-4057qib7 10705 4 transplants transplant NNS cord-005453-4057qib7 10705 5 , , , cord-005453-4057qib7 10705 6 the the DT cord-005453-4057qib7 10705 7 first first JJ cord-005453-4057qib7 10705 8 complicated complicate VBN cord-005453-4057qib7 10705 9 by by IN cord-005453-4057qib7 10705 10 secondary secondary JJ cord-005453-4057qib7 10705 11 graft graft NN cord-005453-4057qib7 10705 12 failure failure NN cord-005453-4057qib7 10705 13 and and CC cord-005453-4057qib7 10705 14 the the DT cord-005453-4057qib7 10705 15 second second JJ cord-005453-4057qib7 10705 16 by by IN cord-005453-4057qib7 10705 17 primary primary JJ cord-005453-4057qib7 10705 18 graft graft NN cord-005453-4057qib7 10705 19 failure failure NN cord-005453-4057qib7 10705 20 he -PRON- PRP cord-005453-4057qib7 10705 21 presented present VBD cord-005453-4057qib7 10705 22 with with IN cord-005453-4057qib7 10705 23 two two CD cord-005453-4057qib7 10705 24 skin skin NN cord-005453-4057qib7 10705 25 lesions lesion NNS cord-005453-4057qib7 10705 26 , , , cord-005453-4057qib7 10705 27 with with IN cord-005453-4057qib7 10705 28 a a DT cord-005453-4057qib7 10705 29 third third JJ cord-005453-4057qib7 10705 30 lesion lesion NN cord-005453-4057qib7 10705 31 adjacent adjacent JJ cord-005453-4057qib7 10705 32 to to IN cord-005453-4057qib7 10705 33 his -PRON- PRP$ cord-005453-4057qib7 10705 34 stoma stoma NN cord-005453-4057qib7 10705 35 developing develop VBG cord-005453-4057qib7 10705 36 shortly shortly RB cord-005453-4057qib7 10705 37 after after IN cord-005453-4057qib7 10705 38 admission admission NN cord-005453-4057qib7 10705 39 . . . cord-005453-4057qib7 10706 1 All all DT cord-005453-4057qib7 10706 2 lesions lesion NNS cord-005453-4057qib7 10706 3 were be VBD cord-005453-4057qib7 10706 4 erythematous erythematous JJ cord-005453-4057qib7 10706 5 with with IN cord-005453-4057qib7 10706 6 central central JJ cord-005453-4057qib7 10706 7 necrosis necrosis NN cord-005453-4057qib7 10706 8 and and CC cord-005453-4057qib7 10706 9 progressed progress VBD cord-005453-4057qib7 10706 10 rapidly rapidly RB cord-005453-4057qib7 10706 11 in in IN cord-005453-4057qib7 10706 12 size size NN cord-005453-4057qib7 10706 13 over over IN cord-005453-4057qib7 10706 14 48 48 CD cord-005453-4057qib7 10706 15 hours hour NNS cord-005453-4057qib7 10706 16 . . . cord-005453-4057qib7 10707 1 Biopsy biopsy NN cord-005453-4057qib7 10707 2 of of IN cord-005453-4057qib7 10707 3 the the DT cord-005453-4057qib7 10707 4 skin skin NN cord-005453-4057qib7 10707 5 and and CC cord-005453-4057qib7 10707 6 para para NNP cord-005453-4057qib7 10707 7 - - HYPH cord-005453-4057qib7 10707 8 stomal stomal JJ cord-005453-4057qib7 10707 9 lesions lesion NNS cord-005453-4057qib7 10707 10 revealed reveal VBD cord-005453-4057qib7 10707 11 fungal fungal JJ cord-005453-4057qib7 10707 12 mycelia mycelium NNS cord-005453-4057qib7 10707 13 , , , cord-005453-4057qib7 10707 14 with with IN cord-005453-4057qib7 10707 15 culture culture NN cord-005453-4057qib7 10707 16 subsequently subsequently RB cord-005453-4057qib7 10707 17 identifying identify VBG cord-005453-4057qib7 10707 18 Rhizopus Rhizopus NNP cord-005453-4057qib7 10707 19 oryzae oryzae NN cord-005453-4057qib7 10707 20 . . . cord-005453-4057qib7 10708 1 Initial initial JJ cord-005453-4057qib7 10708 2 treatment treatment NN cord-005453-4057qib7 10708 3 was be VBD cord-005453-4057qib7 10708 4 with with IN cord-005453-4057qib7 10708 5 liposomal liposomal JJ cord-005453-4057qib7 10708 6 amphotericin amphotericin NNS cord-005453-4057qib7 10708 7 B B NNP cord-005453-4057qib7 10708 8 5mg 5mg NNP cord-005453-4057qib7 10708 9 / / SYM cord-005453-4057qib7 10708 10 kg kg NN cord-005453-4057qib7 10708 11 / / SYM cord-005453-4057qib7 10708 12 day day NN cord-005453-4057qib7 10708 13 followed follow VBN cord-005453-4057qib7 10708 14 by by IN cord-005453-4057qib7 10708 15 dose dose NN cord-005453-4057qib7 10708 16 escalation escalation NN cord-005453-4057qib7 10708 17 to to IN cord-005453-4057qib7 10708 18 10mg 10mg NNP cord-005453-4057qib7 10708 19 / / SYM cord-005453-4057qib7 10708 20 kg kg NN cord-005453-4057qib7 10708 21 / / SYM cord-005453-4057qib7 10708 22 day day NN cord-005453-4057qib7 10708 23 due due JJ cord-005453-4057qib7 10708 24 to to IN cord-005453-4057qib7 10708 25 the the DT cord-005453-4057qib7 10708 26 development development NN cord-005453-4057qib7 10708 27 of of IN cord-005453-4057qib7 10708 28 new new JJ cord-005453-4057qib7 10708 29 skin skin NN cord-005453-4057qib7 10708 30 lesions lesion NNS cord-005453-4057qib7 10708 31 . . . cord-005453-4057qib7 10709 1 The the DT cord-005453-4057qib7 10709 2 patient patient NN cord-005453-4057qib7 10709 3 had have VBD cord-005453-4057qib7 10709 4 been be VBN cord-005453-4057qib7 10709 5 taking take VBG cord-005453-4057qib7 10709 6 posaconazole posaconazole NNP cord-005453-4057qib7 10709 7 ( ( -LRB- cord-005453-4057qib7 10709 8 tablet tablet NN cord-005453-4057qib7 10709 9 ) ) -RRB- cord-005453-4057qib7 10709 10 prophylaxis prophylaxis NN cord-005453-4057qib7 10709 11 since since IN cord-005453-4057qib7 10709 12 his -PRON- PRP$ cord-005453-4057qib7 10709 13 first first JJ cord-005453-4057qib7 10709 14 allogeneic allogeneic NN cord-005453-4057qib7 10709 15 transplant transplant NN cord-005453-4057qib7 10709 16 and and CC cord-005453-4057qib7 10709 17 peripheral peripheral JJ cord-005453-4057qib7 10709 18 blood blood NN cord-005453-4057qib7 10709 19 drug drug NN cord-005453-4057qib7 10709 20 levels level NNS cord-005453-4057qib7 10709 21 checked check VBN cord-005453-4057qib7 10709 22 at at IN cord-005453-4057qib7 10709 23 the the DT cord-005453-4057qib7 10709 24 time time NN cord-005453-4057qib7 10709 25 of of IN cord-005453-4057qib7 10709 26 admission admission NN cord-005453-4057qib7 10709 27 were be VBD cord-005453-4057qib7 10709 28 therapeutic therapeutic JJ cord-005453-4057qib7 10709 29 confirming confirming NN cord-005453-4057qib7 10709 30 that that IN cord-005453-4057qib7 10709 31 this this DT cord-005453-4057qib7 10709 32 was be VBD cord-005453-4057qib7 10709 33 a a DT cord-005453-4057qib7 10709 34 breakthrough breakthrough JJ cord-005453-4057qib7 10709 35 fungal fungal NN cord-005453-4057qib7 10709 36 infection infection NN cord-005453-4057qib7 10709 37 . . . cord-005453-4057qib7 10710 1 Consequently consequently RB cord-005453-4057qib7 10710 2 posaconazole posaconazole NNP cord-005453-4057qib7 10710 3 was be VBD cord-005453-4057qib7 10710 4 stopped stop VBN cord-005453-4057qib7 10710 5 and and CC cord-005453-4057qib7 10710 6 isavuconazole isavuconazole NNP cord-005453-4057qib7 10710 7 added add VBD cord-005453-4057qib7 10710 8 to to IN cord-005453-4057qib7 10710 9 the the DT cord-005453-4057qib7 10710 10 treatment treatment NN cord-005453-4057qib7 10710 11 regimen regimen NN cord-005453-4057qib7 10710 12 . . . cord-005453-4057qib7 10711 1 Surgical surgical JJ cord-005453-4057qib7 10711 2 assessment assessment NN cord-005453-4057qib7 10711 3 was be VBD cord-005453-4057qib7 10711 4 undertaken undertake VBN cord-005453-4057qib7 10711 5 but but CC cord-005453-4057qib7 10711 6 surgery surgery NN cord-005453-4057qib7 10711 7 was be VBD cord-005453-4057qib7 10711 8 deferred defer VBN cord-005453-4057qib7 10711 9 on on IN cord-005453-4057qib7 10711 10 the the DT cord-005453-4057qib7 10711 11 basis basis NN cord-005453-4057qib7 10711 12 of of IN cord-005453-4057qib7 10711 13 high high JJ cord-005453-4057qib7 10711 14 risk risk NN cord-005453-4057qib7 10711 15 due due IN cord-005453-4057qib7 10711 16 to to IN cord-005453-4057qib7 10711 17 the the DT cord-005453-4057qib7 10711 18 extent extent NN cord-005453-4057qib7 10711 19 of of IN cord-005453-4057qib7 10711 20 the the DT cord-005453-4057qib7 10711 21 infection infection NN cord-005453-4057qib7 10711 22 and and CC cord-005453-4057qib7 10711 23 the the DT cord-005453-4057qib7 10711 24 patient´s patient´s NNP cord-005453-4057qib7 10711 25 profound profound JJ cord-005453-4057qib7 10711 26 pancytopenia pancytopenia NNP cord-005453-4057qib7 10711 27 . . . cord-005453-4057qib7 10712 1 The the DT cord-005453-4057qib7 10712 2 organism organism NN cord-005453-4057qib7 10712 3 was be VBD cord-005453-4057qib7 10712 4 tested test VBN cord-005453-4057qib7 10712 5 for for IN cord-005453-4057qib7 10712 6 in in FW cord-005453-4057qib7 10712 7 vitro vitro FW cord-005453-4057qib7 10712 8 susceptibilitiy susceptibilitiy NNP cord-005453-4057qib7 10712 9 and and CC cord-005453-4057qib7 10712 10 found find VBD cord-005453-4057qib7 10712 11 to to TO cord-005453-4057qib7 10712 12 be be VB cord-005453-4057qib7 10712 13 resistant resistant JJ cord-005453-4057qib7 10712 14 to to IN cord-005453-4057qib7 10712 15 posaconazole posaconazole NNP cord-005453-4057qib7 10712 16 ( ( -LRB- cord-005453-4057qib7 10712 17 MIC mic NN cord-005453-4057qib7 10712 18 > > XX cord-005453-4057qib7 10712 19 16mg 16mg NN cord-005453-4057qib7 10712 20 / / SYM cord-005453-4057qib7 10712 21 l l NN cord-005453-4057qib7 10712 22 ) ) -RRB- cord-005453-4057qib7 10712 23 , , , cord-005453-4057qib7 10712 24 with with IN cord-005453-4057qib7 10712 25 borderline borderline JJ cord-005453-4057qib7 10712 26 resistance resistance NN cord-005453-4057qib7 10712 27 to to IN cord-005453-4057qib7 10712 28 isavuconazole isavuconazole NNP cord-005453-4057qib7 10712 29 ( ( -LRB- cord-005453-4057qib7 10712 30 MIC MIC NNP cord-005453-4057qib7 10712 31 16mg 16mg NN cord-005453-4057qib7 10712 32 / / SYM cord-005453-4057qib7 10712 33 L L NNP cord-005453-4057qib7 10712 34 ) ) -RRB- cord-005453-4057qib7 10712 35 and and CC cord-005453-4057qib7 10712 36 sensitive sensitive JJ cord-005453-4057qib7 10712 37 to to IN cord-005453-4057qib7 10712 38 Amphotericin Amphotericin NNP cord-005453-4057qib7 10712 39 B B NNP cord-005453-4057qib7 10712 40 ( ( -LRB- cord-005453-4057qib7 10712 41 MIC mic NN cord-005453-4057qib7 10712 42 0.25mg 0.25mg CD cord-005453-4057qib7 10712 43 / / SYM cord-005453-4057qib7 10712 44 L l NN cord-005453-4057qib7 10712 45 ) ) -RRB- cord-005453-4057qib7 10712 46 ( ( -LRB- cord-005453-4057qib7 10712 47 PHE PHE NNP cord-005453-4057qib7 10712 48 Mycology Mycology NNP cord-005453-4057qib7 10712 49 Reference Reference NNP cord-005453-4057qib7 10712 50 Laboratory Laboratory NNP cord-005453-4057qib7 10712 51 , , , cord-005453-4057qib7 10712 52 England England NNP cord-005453-4057qib7 10712 53 ) ) -RRB- cord-005453-4057qib7 10712 54 . . . cord-005453-4057qib7 10713 1 Isavuconazole Isavuconazole NNP cord-005453-4057qib7 10713 2 was be VBD cord-005453-4057qib7 10713 3 therefore therefore RB cord-005453-4057qib7 10713 4 stopped stop VBN cord-005453-4057qib7 10713 5 and and CC cord-005453-4057qib7 10713 6 the the DT cord-005453-4057qib7 10713 7 patient patient NN cord-005453-4057qib7 10713 8 was be VBD cord-005453-4057qib7 10713 9 managed manage VBN cord-005453-4057qib7 10713 10 with with IN cord-005453-4057qib7 10713 11 liposomal liposomal JJ cord-005453-4057qib7 10713 12 amphotericin amphotericin NNS cord-005453-4057qib7 10713 13 B B NNP cord-005453-4057qib7 10713 14 along along IN cord-005453-4057qib7 10713 15 with with IN cord-005453-4057qib7 10713 16 daily daily JJ cord-005453-4057qib7 10713 17 granulocyte granulocyte NN cord-005453-4057qib7 10713 18 infusions infusion NNS cord-005453-4057qib7 10713 19 . . . cord-005453-4057qib7 10714 1 He -PRON- PRP cord-005453-4057qib7 10714 2 underwent undergo VBD cord-005453-4057qib7 10714 3 a a DT cord-005453-4057qib7 10714 4 third third JJ cord-005453-4057qib7 10714 5 allogeneic allogeneic NN cord-005453-4057qib7 10714 6 transplant transplant NN cord-005453-4057qib7 10714 7 using use VBG cord-005453-4057qib7 10714 8 a a DT cord-005453-4057qib7 10714 9 different different JJ cord-005453-4057qib7 10714 10 unrelated unrelated JJ cord-005453-4057qib7 10714 11 donor donor NN cord-005453-4057qib7 10714 12 and and CC cord-005453-4057qib7 10714 13 stable stable JJ cord-005453-4057qib7 10714 14 engraftment engraftment NN cord-005453-4057qib7 10714 15 was be VBD cord-005453-4057qib7 10714 16 achieved achieve VBN cord-005453-4057qib7 10714 17 . . . cord-005453-4057qib7 10715 1 Post post JJ cord-005453-4057qib7 10715 2 transplant transplant NN cord-005453-4057qib7 10715 3 there there EX cord-005453-4057qib7 10715 4 was be VBD cord-005453-4057qib7 10715 5 initially initially RB cord-005453-4057qib7 10715 6 an an DT cord-005453-4057qib7 10715 7 increase increase NN cord-005453-4057qib7 10715 8 in in IN cord-005453-4057qib7 10715 9 the the DT cord-005453-4057qib7 10715 10 size size NN cord-005453-4057qib7 10715 11 of of IN cord-005453-4057qib7 10715 12 the the DT cord-005453-4057qib7 10715 13 para para NNP cord-005453-4057qib7 10715 14 - - HYPH cord-005453-4057qib7 10715 15 stomal stomal NNP cord-005453-4057qib7 10715 16 lesion lesion NN cord-005453-4057qib7 10715 17 , , , cord-005453-4057qib7 10715 18 but but CC cord-005453-4057qib7 10715 19 no no DT cord-005453-4057qib7 10715 20 new new JJ cord-005453-4057qib7 10715 21 skin skin NN cord-005453-4057qib7 10715 22 lesions lesion NNS cord-005453-4057qib7 10715 23 developed develop VBN cord-005453-4057qib7 10715 24 . . . cord-005453-4057qib7 10716 1 Following follow VBG cord-005453-4057qib7 10716 2 engraftment engraftment NN cord-005453-4057qib7 10716 3 he -PRON- PRP cord-005453-4057qib7 10716 4 underwent undergo VBD cord-005453-4057qib7 10716 5 resection resection NN cord-005453-4057qib7 10716 6 of of IN cord-005453-4057qib7 10716 7 the the DT cord-005453-4057qib7 10716 8 stomal stomal NNP cord-005453-4057qib7 10716 9 lesion lesion NN cord-005453-4057qib7 10716 10 , , , cord-005453-4057qib7 10716 11 with with IN cord-005453-4057qib7 10716 12 primary primary JJ cord-005453-4057qib7 10716 13 closure closure NN cord-005453-4057qib7 10716 14 and and CC cord-005453-4057qib7 10716 15 re re NN cord-005453-4057qib7 10716 16 - - NN cord-005453-4057qib7 10716 17 siting siting NN cord-005453-4057qib7 10716 18 of of IN cord-005453-4057qib7 10716 19 his -PRON- PRP$ cord-005453-4057qib7 10716 20 stoma stoma NN cord-005453-4057qib7 10716 21 . . . cord-005453-4057qib7 10717 1 Amphotericin Amphotericin NNP cord-005453-4057qib7 10717 2 B B NNP cord-005453-4057qib7 10717 3 was be VBD cord-005453-4057qib7 10717 4 replaced replace VBN cord-005453-4057qib7 10717 5 by by IN cord-005453-4057qib7 10717 6 isavuconazole isavuconazole NNP cord-005453-4057qib7 10717 7 prophylaxis prophylaxis NN cord-005453-4057qib7 10717 8 on on IN cord-005453-4057qib7 10717 9 discharge discharge NN cord-005453-4057qib7 10717 10 and and CC cord-005453-4057qib7 10717 11 he -PRON- PRP cord-005453-4057qib7 10717 12 continues continue VBZ cord-005453-4057qib7 10717 13 to to TO cord-005453-4057qib7 10717 14 make make VB cord-005453-4057qib7 10717 15 an an DT cord-005453-4057qib7 10717 16 excellent excellent JJ cord-005453-4057qib7 10717 17 recovery recovery NN cord-005453-4057qib7 10717 18 . . . cord-005453-4057qib7 10718 1 Conclusions conclusion NNS cord-005453-4057qib7 10718 2 : : : cord-005453-4057qib7 10719 1 Whilst whilst IN cord-005453-4057qib7 10719 2 Aspergillus aspergillus NN cord-005453-4057qib7 10719 3 species specie NNS cord-005453-4057qib7 10719 4 remain remain VBP cord-005453-4057qib7 10719 5 the the DT cord-005453-4057qib7 10719 6 most most RBS cord-005453-4057qib7 10719 7 common common JJ cord-005453-4057qib7 10719 8 cause cause NN cord-005453-4057qib7 10719 9 of of IN cord-005453-4057qib7 10719 10 invasive invasive JJ cord-005453-4057qib7 10719 11 fungal fungal JJ cord-005453-4057qib7 10719 12 infections infection NNS cord-005453-4057qib7 10719 13 in in IN cord-005453-4057qib7 10719 14 allogeneic allogeneic NN cord-005453-4057qib7 10719 15 transplant transplant NN cord-005453-4057qib7 10719 16 patients patient NNS cord-005453-4057qib7 10719 17 , , , cord-005453-4057qib7 10719 18 other other JJ cord-005453-4057qib7 10719 19 species specie NNS cord-005453-4057qib7 10719 20 including include VBG cord-005453-4057qib7 10719 21 the the DT cord-005453-4057qib7 10719 22 Mucorales Mucorales NNPS cord-005453-4057qib7 10719 23 are be VBP cord-005453-4057qib7 10719 24 seen see VBN cord-005453-4057qib7 10719 25 , , , cord-005453-4057qib7 10719 26 and and CC cord-005453-4057qib7 10719 27 generally generally RB cord-005453-4057qib7 10719 28 associated associate VBN cord-005453-4057qib7 10719 29 with with IN cord-005453-4057qib7 10719 30 poorer poor JJR cord-005453-4057qib7 10719 31 outcomes outcome NNS cord-005453-4057qib7 10719 32 . . . cord-005453-4057qib7 10720 1 Whilst whilst IN cord-005453-4057qib7 10720 2 there there EX cord-005453-4057qib7 10720 3 are be VBP cord-005453-4057qib7 10720 4 standardised standardised JJ cord-005453-4057qib7 10720 5 methodologies methodology NNS cord-005453-4057qib7 10720 6 for for IN cord-005453-4057qib7 10720 7 susceptibility susceptibility NN cord-005453-4057qib7 10720 8 testing testing NN cord-005453-4057qib7 10720 9 , , , cord-005453-4057qib7 10720 10 fungi fungus NNS cord-005453-4057qib7 10720 11 specific specific JJ cord-005453-4057qib7 10720 12 cut cut NN cord-005453-4057qib7 10720 13 offs off NNS cord-005453-4057qib7 10720 14 based base VBN cord-005453-4057qib7 10720 15 on on IN cord-005453-4057qib7 10720 16 clinical clinical JJ cord-005453-4057qib7 10720 17 outcomes outcome NNS cord-005453-4057qib7 10720 18 are be VBP cord-005453-4057qib7 10720 19 only only RB cord-005453-4057qib7 10720 20 available available JJ cord-005453-4057qib7 10720 21 for for IN cord-005453-4057qib7 10720 22 a a DT cord-005453-4057qib7 10720 23 limited limited JJ cord-005453-4057qib7 10720 24 number number NN cord-005453-4057qib7 10720 25 of of IN cord-005453-4057qib7 10720 26 species/ species/ CD cord-005453-4057qib7 10720 27 antifungal antifungal JJ cord-005453-4057qib7 10720 28 agents agent NNS cord-005453-4057qib7 10720 29 . . . cord-005453-4057qib7 10721 1 In in IN cord-005453-4057qib7 10721 2 this this DT cord-005453-4057qib7 10721 3 case case NN cord-005453-4057qib7 10721 4 , , , cord-005453-4057qib7 10721 5 susceptibility susceptibility NN cord-005453-4057qib7 10721 6 testing testing NN cord-005453-4057qib7 10721 7 demonstrated demonstrate VBD cord-005453-4057qib7 10721 8 resistance resistance NN cord-005453-4057qib7 10721 9 to to IN cord-005453-4057qib7 10721 10 posaconazole posaconazole NNP cord-005453-4057qib7 10721 11 which which WDT cord-005453-4057qib7 10721 12 was be VBD cord-005453-4057qib7 10721 13 consistent consistent JJ cord-005453-4057qib7 10721 14 with with IN cord-005453-4057qib7 10721 15 the the DT cord-005453-4057qib7 10721 16 clinical clinical JJ cord-005453-4057qib7 10721 17 presentation presentation NN cord-005453-4057qib7 10721 18 of of IN cord-005453-4057qib7 10721 19 invasive invasive JJ cord-005453-4057qib7 10721 20 infection infection NN cord-005453-4057qib7 10721 21 despite despite IN cord-005453-4057qib7 10721 22 therapeutic therapeutic JJ cord-005453-4057qib7 10721 23 levels level NNS cord-005453-4057qib7 10721 24 of of IN cord-005453-4057qib7 10721 25 posaconazole posaconazole NN cord-005453-4057qib7 10721 26 . . . cord-005453-4057qib7 10722 1 It -PRON- PRP cord-005453-4057qib7 10722 2 is be VBZ cord-005453-4057qib7 10722 3 also also RB cord-005453-4057qib7 10722 4 worth worth JJ cord-005453-4057qib7 10722 5 noting note VBG cord-005453-4057qib7 10722 6 that that IN cord-005453-4057qib7 10722 7 an an DT cord-005453-4057qib7 10722 8 estimated estimate VBN cord-005453-4057qib7 10722 9 45 45 CD cord-005453-4057qib7 10722 10 % % NN cord-005453-4057qib7 10722 11 of of IN cord-005453-4057qib7 10722 12 R. R. NNP cord-005453-4057qib7 10722 13 oryzae oryzae NN cord-005453-4057qib7 10722 14 isolates isolate VBZ cord-005453-4057qib7 10722 15 in in IN cord-005453-4057qib7 10722 16 the the DT cord-005453-4057qib7 10722 17 UK UK NNP cord-005453-4057qib7 10722 18 are be VBP cord-005453-4057qib7 10722 19 resistant resistant JJ cord-005453-4057qib7 10722 20 to to IN cord-005453-4057qib7 10722 21 posaconazole posaconazole NNP cord-005453-4057qib7 10722 22 . . . cord-005453-4057qib7 10723 1 Treatment treatment NN cord-005453-4057qib7 10723 2 with with IN cord-005453-4057qib7 10723 3 high high JJ cord-005453-4057qib7 10723 4 dose dose NN cord-005453-4057qib7 10723 5 Amphotericin Amphotericin NNP cord-005453-4057qib7 10723 6 B B NNP cord-005453-4057qib7 10723 7 resulted result VBD cord-005453-4057qib7 10723 8 in in IN cord-005453-4057qib7 10723 9 improvement improvement NN cord-005453-4057qib7 10723 10 in in IN cord-005453-4057qib7 10723 11 small small JJ cord-005453-4057qib7 10723 12 skin skin NN cord-005453-4057qib7 10723 13 lesions lesion NNS cord-005453-4057qib7 10723 14 with with IN cord-005453-4057qib7 10723 15 stabilisation stabilisation NN cord-005453-4057qib7 10723 16 of of IN cord-005453-4057qib7 10723 17 the the DT cord-005453-4057qib7 10723 18 larger large JJR cord-005453-4057qib7 10723 19 stomal stomal NNP cord-005453-4057qib7 10723 20 lesion lesion NN cord-005453-4057qib7 10723 21 until until IN cord-005453-4057qib7 10723 22 count count NN cord-005453-4057qib7 10723 23 recovery recovery NN cord-005453-4057qib7 10723 24 allowed allow VBD cord-005453-4057qib7 10723 25 surgical surgical JJ cord-005453-4057qib7 10723 26 resection resection NN cord-005453-4057qib7 10723 27 . . . cord-005453-4057qib7 10724 1 Background background NN cord-005453-4057qib7 10724 2 : : : cord-005453-4057qib7 10725 1 Total total JJ cord-005453-4057qib7 10725 2 depletion depletion NN cord-005453-4057qib7 10725 3 of of IN cord-005453-4057qib7 10725 4 innate innate JJ cord-005453-4057qib7 10725 5 and and CC cord-005453-4057qib7 10725 6 adaptive adaptive JJ cord-005453-4057qib7 10725 7 immune immune JJ cord-005453-4057qib7 10725 8 cell cell NN cord-005453-4057qib7 10725 9 populations population NNS cord-005453-4057qib7 10725 10 occurs occur VBZ cord-005453-4057qib7 10725 11 after after IN cord-005453-4057qib7 10725 12 intensive intensive JJ cord-005453-4057qib7 10725 13 chemotherapy chemotherapy NN cord-005453-4057qib7 10725 14 and and CC cord-005453-4057qib7 10725 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 10725 16 stem stem NN cord-005453-4057qib7 10725 17 cell cell NN cord-005453-4057qib7 10725 18 transplantation transplantation NN cord-005453-4057qib7 10725 19 ( ( -LRB- cord-005453-4057qib7 10725 20 HSCT HSCT NNP cord-005453-4057qib7 10725 21 ) ) -RRB- cord-005453-4057qib7 10725 22 . . . cord-005453-4057qib7 10726 1 Both both DT cord-005453-4057qib7 10726 2 T t NN cord-005453-4057qib7 10726 3 and and CC cord-005453-4057qib7 10726 4 B b NN cord-005453-4057qib7 10726 5 lymphocyte lymphocyte NN cord-005453-4057qib7 10726 6 pools pool NNS cord-005453-4057qib7 10726 7 are be VBP cord-005453-4057qib7 10726 8 restored restore VBN cord-005453-4057qib7 10726 9 slower slow RBR cord-005453-4057qib7 10726 10 that that IN cord-005453-4057qib7 10726 11 myelomonocytic myelomonocytic JJ cord-005453-4057qib7 10726 12 populations population NNS cord-005453-4057qib7 10726 13 . . . cord-005453-4057qib7 10727 1 HSCT HSCT NNP cord-005453-4057qib7 10727 2 patients patient NNS cord-005453-4057qib7 10727 3 are be VBP cord-005453-4057qib7 10727 4 at at IN cord-005453-4057qib7 10727 5 high high JJ cord-005453-4057qib7 10727 6 risk risk NN cord-005453-4057qib7 10727 7 for for IN cord-005453-4057qib7 10727 8 bacterial bacterial JJ cord-005453-4057qib7 10727 9 and and CC cord-005453-4057qib7 10727 10 viral viral JJ cord-005453-4057qib7 10727 11 infections infection NNS cord-005453-4057qib7 10727 12 at at IN cord-005453-4057qib7 10727 13 early early JJ cord-005453-4057qib7 10727 14 terms term NNS cord-005453-4057qib7 10727 15 ( ( -LRB- cord-005453-4057qib7 10727 16 < < NNP cord-005453-4057qib7 10727 17 100 100 CD cord-005453-4057qib7 10727 18 days day NNS cord-005453-4057qib7 10727 19 ) ) -RRB- cord-005453-4057qib7 10727 20 post post JJ cord-005453-4057qib7 10727 21 - - NN cord-005453-4057qib7 10727 22 transplant transplant NN cord-005453-4057qib7 10727 23 . . . cord-005453-4057qib7 10728 1 The the DT cord-005453-4057qib7 10728 2 reconstitution reconstitution NN cord-005453-4057qib7 10728 3 of of IN cord-005453-4057qib7 10728 4 the the DT cord-005453-4057qib7 10728 5 immune immune JJ cord-005453-4057qib7 10728 6 system system NN cord-005453-4057qib7 10728 7 depends depend VBZ cord-005453-4057qib7 10728 8 on on IN cord-005453-4057qib7 10728 9 the the DT cord-005453-4057qib7 10728 10 time time NN cord-005453-4057qib7 10728 11 required require VBN cord-005453-4057qib7 10728 12 for for IN cord-005453-4057qib7 10728 13 stem stem NN cord-005453-4057qib7 10728 14 cell cell NN cord-005453-4057qib7 10728 15 recruitment recruitment NN cord-005453-4057qib7 10728 16 , , , cord-005453-4057qib7 10728 17 differentiation differentiation NN cord-005453-4057qib7 10728 18 , , , cord-005453-4057qib7 10728 19 expansion expansion NN cord-005453-4057qib7 10728 20 , , , cord-005453-4057qib7 10728 21 maturation maturation NN cord-005453-4057qib7 10728 22 and and CC cord-005453-4057qib7 10728 23 release release NN cord-005453-4057qib7 10728 24 into into IN cord-005453-4057qib7 10728 25 the the DT cord-005453-4057qib7 10728 26 bloodstream bloodstream NN cord-005453-4057qib7 10728 27 . . . cord-005453-4057qib7 10729 1 Restoration restoration NN cord-005453-4057qib7 10729 2 terms term NNS cord-005453-4057qib7 10729 3 for for IN cord-005453-4057qib7 10729 4 myeloid myeloid JJ cord-005453-4057qib7 10729 5 cells cell NNS cord-005453-4057qib7 10729 6 after after IN cord-005453-4057qib7 10729 7 HSCT HSCT NNP cord-005453-4057qib7 10729 8 are be VBP cord-005453-4057qib7 10729 9 usually usually RB cord-005453-4057qib7 10729 10 defined define VBN cord-005453-4057qib7 10729 11 as as IN cord-005453-4057qib7 10729 12 the the DT cord-005453-4057qib7 10729 13 1st 1st JJ cord-005453-4057qib7 10729 14 day day NN cord-005453-4057qib7 10729 15 with with IN cord-005453-4057qib7 10729 16 neutrophil neutrophil NN cord-005453-4057qib7 10729 17 count count NN cord-005453-4057qib7 10729 18 of of IN cord-005453-4057qib7 10729 19 ≥ ≥ CD cord-005453-4057qib7 10729 20 0.5 0.5 CD cord-005453-4057qib7 10729 21 x x SYM cord-005453-4057qib7 10729 22 10 10 CD cord-005453-4057qib7 10729 23 ^ ^ SYM cord-005453-4057qib7 10729 24 9 9 CD cord-005453-4057qib7 10729 25 / / SYM cord-005453-4057qib7 10729 26 L l NN cord-005453-4057qib7 10729 27 with with IN cord-005453-4057qib7 10729 28 mean mean JJ cord-005453-4057qib7 10729 29 recovery recovery NN cord-005453-4057qib7 10729 30 terms term NNS cord-005453-4057qib7 10729 31 of of IN cord-005453-4057qib7 10729 32 12 12 CD cord-005453-4057qib7 10729 33 to to TO cord-005453-4057qib7 10729 34 20 20 CD cord-005453-4057qib7 10729 35 days day NNS cord-005453-4057qib7 10729 36 . . . cord-005453-4057qib7 10730 1 High high JJ cord-005453-4057qib7 10730 2 occurrence occurrence NN cord-005453-4057qib7 10730 3 of of IN cord-005453-4057qib7 10730 4 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 10730 5 ( ( -LRB- cord-005453-4057qib7 10730 6 CMV CMV NNP cord-005453-4057qib7 10730 7 ) ) -RRB- cord-005453-4057qib7 10730 8 in in IN cord-005453-4057qib7 10730 9 HSCT HSCT NNP cord-005453-4057qib7 10730 10 patients patient NNS cord-005453-4057qib7 10730 11 mostly mostly RB cord-005453-4057qib7 10730 12 result result VBP cord-005453-4057qib7 10730 13 from from IN cord-005453-4057qib7 10730 14 reactivation reactivation NN cord-005453-4057qib7 10730 15 of of IN cord-005453-4057qib7 10730 16 a a DT cord-005453-4057qib7 10730 17 latent latent JJ cord-005453-4057qib7 10730 18 virus virus NN cord-005453-4057qib7 10730 19 acquired acquire VBN cord-005453-4057qib7 10730 20 in in IN cord-005453-4057qib7 10730 21 early early JJ cord-005453-4057qib7 10730 22 childhood childhood NN cord-005453-4057qib7 10730 23 . . . cord-005453-4057qib7 10731 1 However however RB cord-005453-4057qib7 10731 2 , , , cord-005453-4057qib7 10731 3 delayed delay VBN cord-005453-4057qib7 10731 4 immune immune JJ cord-005453-4057qib7 10731 5 reconstitution reconstitution NN cord-005453-4057qib7 10731 6 and and CC cord-005453-4057qib7 10731 7 subsequent subsequent JJ cord-005453-4057qib7 10731 8 infections infection NNS cord-005453-4057qib7 10731 9 such such JJ cord-005453-4057qib7 10731 10 as as IN cord-005453-4057qib7 10731 11 CMV CMV NNP cord-005453-4057qib7 10731 12 , , , cord-005453-4057qib7 10731 13 adenovirus adenovirus NN cord-005453-4057qib7 10731 14 ( ( -LRB- cord-005453-4057qib7 10731 15 ADV ADV NNP cord-005453-4057qib7 10731 16 ) ) -RRB- cord-005453-4057qib7 10731 17 or or CC cord-005453-4057qib7 10731 18 Herpes Herpes NNP cord-005453-4057qib7 10731 19 6 6 CD cord-005453-4057qib7 10732 1 ( ( -LRB- cord-005453-4057qib7 10732 2 HHV-6 HHV-6 NNP cord-005453-4057qib7 10732 3 ) ) -RRB- cord-005453-4057qib7 10732 4 diseases disease NNS cord-005453-4057qib7 10732 5 are be VBP cord-005453-4057qib7 10732 6 not not RB cord-005453-4057qib7 10732 7 unusual unusual JJ cord-005453-4057qib7 10732 8 and and CC cord-005453-4057qib7 10732 9 still still RB cord-005453-4057qib7 10732 10 constitute constitute VB cord-005453-4057qib7 10732 11 a a DT cord-005453-4057qib7 10732 12 major major JJ cord-005453-4057qib7 10732 13 cause cause NN cord-005453-4057qib7 10732 14 of of IN cord-005453-4057qib7 10732 15 death death NN cord-005453-4057qib7 10732 16 in in IN cord-005453-4057qib7 10732 17 Peru Peru NNP cord-005453-4057qib7 10732 18 . . . cord-005453-4057qib7 10733 1 Methods method NNS cord-005453-4057qib7 10733 2 : : : cord-005453-4057qib7 10733 3 Peruvian peruvian JJ cord-005453-4057qib7 10733 4 pediatric pediatric JJ cord-005453-4057qib7 10733 5 patients patient NNS cord-005453-4057qib7 10733 6 ( ( -LRB- cord-005453-4057qib7 10733 7 n=22 n=22 NNP cord-005453-4057qib7 10733 8 ) ) -RRB- cord-005453-4057qib7 10733 9 diagnosed diagnose VBN cord-005453-4057qib7 10733 10 with with IN cord-005453-4057qib7 10733 11 aplastic aplastic JJ cord-005453-4057qib7 10733 12 anemia anemia NN cord-005453-4057qib7 10733 13 , , , cord-005453-4057qib7 10733 14 MDS MDS NNP cord-005453-4057qib7 10733 15 , , , cord-005453-4057qib7 10733 16 AML AML NNP cord-005453-4057qib7 10733 17 or or CC cord-005453-4057qib7 10733 18 ALL all DT cord-005453-4057qib7 10733 19 underwent undergo VBD cord-005453-4057qib7 10733 20 a a DT cord-005453-4057qib7 10733 21 haploidentical haploidentical JJ cord-005453-4057qib7 10733 22 HSCT HSCT NNP cord-005453-4057qib7 10733 23 performed perform VBN cord-005453-4057qib7 10733 24 with with IN cord-005453-4057qib7 10733 25 the the DT cord-005453-4057qib7 10733 26 CliniMACS CliniMACS NNP cord-005453-4057qib7 10733 27 device device NN cord-005453-4057qib7 10733 28 . . . cord-005453-4057qib7 10734 1 Patients patient NNS cord-005453-4057qib7 10734 2 treated treat VBN cord-005453-4057qib7 10734 3 were be VBD cord-005453-4057qib7 10734 4 separated separate VBN cord-005453-4057qib7 10734 5 in in IN cord-005453-4057qib7 10734 6 two two CD cord-005453-4057qib7 10734 7 groups group NNS cord-005453-4057qib7 10734 8 . . . cord-005453-4057qib7 10735 1 The the DT cord-005453-4057qib7 10735 2 group group NN cord-005453-4057qib7 10735 3 of of IN cord-005453-4057qib7 10735 4 patients patient NNS cord-005453-4057qib7 10735 5 who who WP cord-005453-4057qib7 10735 6 received receive VBD cord-005453-4057qib7 10735 7 viral viral JJ cord-005453-4057qib7 10735 8 prophylaxis prophylaxis NN cord-005453-4057qib7 10735 9 ( ( -LRB- cord-005453-4057qib7 10735 10 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 10735 11 ) ) -RRB- cord-005453-4057qib7 10735 12 was be VBD cord-005453-4057qib7 10735 13 compared compare VBN cord-005453-4057qib7 10735 14 to to IN cord-005453-4057qib7 10735 15 the the DT cord-005453-4057qib7 10735 16 group group NN cord-005453-4057qib7 10735 17 that that WDT cord-005453-4057qib7 10735 18 did do VBD cord-005453-4057qib7 10735 19 not not RB cord-005453-4057qib7 10735 20 receive receive VB cord-005453-4057qib7 10735 21 any any DT cord-005453-4057qib7 10735 22 prophylaxis prophylaxis NN cord-005453-4057qib7 10735 23 treatment treatment NN cord-005453-4057qib7 10735 24 . . . cord-005453-4057qib7 10736 1 Viral viral JJ cord-005453-4057qib7 10736 2 reactivation reactivation NN cord-005453-4057qib7 10736 3 was be VBD cord-005453-4057qib7 10736 4 confirmed confirm VBN cord-005453-4057qib7 10736 5 by by IN cord-005453-4057qib7 10736 6 PCR PCR NNP cord-005453-4057qib7 10736 7 test test NN cord-005453-4057qib7 10736 8 twice twice PDT cord-005453-4057qib7 10736 9 a a DT cord-005453-4057qib7 10736 10 week week NN cord-005453-4057qib7 10736 11 and and CC cord-005453-4057qib7 10736 12 clinical clinical JJ cord-005453-4057qib7 10736 13 signs sign NNS cord-005453-4057qib7 10736 14 within within IN cord-005453-4057qib7 10736 15 15 15 CD cord-005453-4057qib7 10736 16 days day NNS cord-005453-4057qib7 10736 17 after after IN cord-005453-4057qib7 10736 18 HSCT HSCT NNP cord-005453-4057qib7 10736 19 . . . cord-005453-4057qib7 10737 1 Results result NNS cord-005453-4057qib7 10737 2 : : : cord-005453-4057qib7 10738 1 In in IN cord-005453-4057qib7 10738 2 the the DT cord-005453-4057qib7 10738 3 group group NN cord-005453-4057qib7 10738 4 that that WDT cord-005453-4057qib7 10738 5 didn´t didn´t NNP cord-005453-4057qib7 10738 6 received receive VBD cord-005453-4057qib7 10738 7 prophylactic prophylactic JJ cord-005453-4057qib7 10738 8 treatment treatment NN cord-005453-4057qib7 10738 9 , , , cord-005453-4057qib7 10738 10 engraftment engraftment NN cord-005453-4057qib7 10738 11 occurred occur VBD cord-005453-4057qib7 10738 12 close close RB cord-005453-4057qib7 10738 13 to to IN cord-005453-4057qib7 10738 14 day day NN cord-005453-4057qib7 10738 15 10 10 CD cord-005453-4057qib7 10738 16 post post NN cord-005453-4057qib7 10738 17 haplo haplo NN cord-005453-4057qib7 10738 18 - - HYPH cord-005453-4057qib7 10738 19 HSCT HSCT NNP cord-005453-4057qib7 10738 20 and and CC cord-005453-4057qib7 10738 21 none none NN cord-005453-4057qib7 10738 22 of of IN cord-005453-4057qib7 10738 23 the the DT cord-005453-4057qib7 10738 24 patients patient NNS cord-005453-4057qib7 10738 25 developed develop VBD cord-005453-4057qib7 10738 26 GvHD GvHD NNP cord-005453-4057qib7 10738 27 ( ( -LRB- cord-005453-4057qib7 10738 28 graft graft NN cord-005453-4057qib7 10738 29 versus versus IN cord-005453-4057qib7 10738 30 host host NN cord-005453-4057qib7 10738 31 disease disease NN cord-005453-4057qib7 10738 32 ) ) -RRB- cord-005453-4057qib7 10738 33 . . . cord-005453-4057qib7 10739 1 Nevertheless nevertheless RB cord-005453-4057qib7 10739 2 , , , cord-005453-4057qib7 10739 3 incidences incidence NNS cord-005453-4057qib7 10739 4 of of IN cord-005453-4057qib7 10739 5 CMV CMV NNP cord-005453-4057qib7 10739 6 , , , cord-005453-4057qib7 10739 7 HHV-6 HHV-6 NNP cord-005453-4057qib7 10739 8 and and CC cord-005453-4057qib7 10739 9 BKV BKV NNP cord-005453-4057qib7 10739 10 infections infection NNS cord-005453-4057qib7 10739 11 before before IN cord-005453-4057qib7 10739 12 day day NN cord-005453-4057qib7 10740 1 15 15 CD cord-005453-4057qib7 10740 2 post post NN cord-005453-4057qib7 10740 3 haplo haplo NNP cord-005453-4057qib7 10740 4 - - HYPH cord-005453-4057qib7 10740 5 HSCT HSCT NNP cord-005453-4057qib7 10740 6 were be VBD cord-005453-4057qib7 10740 7 still still RB cord-005453-4057qib7 10740 8 high high JJ cord-005453-4057qib7 10740 9 . . . cord-005453-4057qib7 10741 1 An an DT cord-005453-4057qib7 10741 2 overall overall JJ cord-005453-4057qib7 10741 3 survival survival NN cord-005453-4057qib7 10741 4 ( ( -LRB- cord-005453-4057qib7 10741 5 OS OS NNP cord-005453-4057qib7 10741 6 ) ) -RRB- cord-005453-4057qib7 10741 7 over over IN cord-005453-4057qib7 10741 8 65 65 CD cord-005453-4057qib7 10741 9 % % NN cord-005453-4057qib7 10741 10 with with IN cord-005453-4057qib7 10741 11 an an DT cord-005453-4057qib7 10741 12 IC IC NNP cord-005453-4057qib7 10741 13 95 95 CD cord-005453-4057qib7 10741 14 % % NN cord-005453-4057qib7 10741 15 was be VBD cord-005453-4057qib7 10741 16 reached reach VBN cord-005453-4057qib7 10741 17 at at IN cord-005453-4057qib7 10741 18 the the DT cord-005453-4057qib7 10741 19 end end NN cord-005453-4057qib7 10741 20 of of IN cord-005453-4057qib7 10741 21 the the DT cord-005453-4057qib7 10741 22 first first JJ cord-005453-4057qib7 10741 23 year year NN cord-005453-4057qib7 10741 24 . . . cord-005453-4057qib7 10742 1 On on IN cord-005453-4057qib7 10742 2 the the DT cord-005453-4057qib7 10742 3 other other JJ cord-005453-4057qib7 10742 4 hand hand NN cord-005453-4057qib7 10742 5 , , , cord-005453-4057qib7 10742 6 the the DT cord-005453-4057qib7 10742 7 group group NN cord-005453-4057qib7 10742 8 of of IN cord-005453-4057qib7 10742 9 patients patient NNS cord-005453-4057qib7 10742 10 that that WDT cord-005453-4057qib7 10742 11 received receive VBD cord-005453-4057qib7 10742 12 prophylaxis prophylaxis NN cord-005453-4057qib7 10742 13 with with IN cord-005453-4057qib7 10742 14 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 10742 15 did do VBD cord-005453-4057qib7 10742 16 not not RB cord-005453-4057qib7 10742 17 developed develop VBN cord-005453-4057qib7 10742 18 GvHD GvHD NNP cord-005453-4057qib7 10742 19 and and CC cord-005453-4057qib7 10742 20 reached reach VBD cord-005453-4057qib7 10742 21 the the DT cord-005453-4057qib7 10742 22 engraftment engraftment NN cord-005453-4057qib7 10742 23 close close JJ cord-005453-4057qib7 10742 24 to to IN cord-005453-4057qib7 10742 25 day day NN cord-005453-4057qib7 10742 26 10 10 CD cord-005453-4057qib7 10742 27 with with IN cord-005453-4057qib7 10742 28 a a DT cord-005453-4057qib7 10742 29 very very RB cord-005453-4057qib7 10742 30 low low JJ cord-005453-4057qib7 10742 31 viremia viremia NN cord-005453-4057qib7 10742 32 incidence incidence NN cord-005453-4057qib7 10742 33 after after IN cord-005453-4057qib7 10742 34 the the DT cord-005453-4057qib7 10742 35 first first JJ cord-005453-4057qib7 10742 36 month month NN cord-005453-4057qib7 10742 37 post post NN cord-005453-4057qib7 10742 38 haplo haplo NNP cord-005453-4057qib7 10742 39 - - HYPH cord-005453-4057qib7 10742 40 HSCT HSCT NNP cord-005453-4057qib7 10742 41 . . . cord-005453-4057qib7 10743 1 All all DT cord-005453-4057qib7 10743 2 viral viral JJ cord-005453-4057qib7 10743 3 reactivations reactivation NNS cord-005453-4057qib7 10743 4 were be VBD cord-005453-4057qib7 10743 5 caused cause VBN cord-005453-4057qib7 10743 6 by by IN cord-005453-4057qib7 10743 7 CMV CMV NNP cord-005453-4057qib7 10743 8 and and CC cord-005453-4057qib7 10743 9 the the DT cord-005453-4057qib7 10743 10 OS OS NNP cord-005453-4057qib7 10743 11 was be VBD cord-005453-4057qib7 10743 12 over over IN cord-005453-4057qib7 10743 13 91 91 CD cord-005453-4057qib7 10743 14 % % NN cord-005453-4057qib7 10743 15 with with IN cord-005453-4057qib7 10743 16 an an DT cord-005453-4057qib7 10743 17 IC IC NNP cord-005453-4057qib7 10743 18 95 95 CD cord-005453-4057qib7 10743 19 % % NN cord-005453-4057qib7 10743 20 at at IN cord-005453-4057qib7 10743 21 the the DT cord-005453-4057qib7 10743 22 end end NN cord-005453-4057qib7 10743 23 of of IN cord-005453-4057qib7 10743 24 the the DT cord-005453-4057qib7 10743 25 first first JJ cord-005453-4057qib7 10743 26 year year NN cord-005453-4057qib7 10743 27 . . . cord-005453-4057qib7 10744 1 Previous previous JJ cord-005453-4057qib7 10744 2 prophylaxis prophylaxis NN cord-005453-4057qib7 10744 3 to to IN cord-005453-4057qib7 10744 4 both both CC cord-005453-4057qib7 10744 5 the the DT cord-005453-4057qib7 10744 6 donor donor NN cord-005453-4057qib7 10744 7 and and CC cord-005453-4057qib7 10744 8 the the DT cord-005453-4057qib7 10744 9 receptor receptor NN cord-005453-4057qib7 10744 10 with with IN cord-005453-4057qib7 10744 11 Ganciclovir Ganciclovir NNP cord-005453-4057qib7 10744 12 ( ( -LRB- cord-005453-4057qib7 10744 13 5mg 5mg NNP cord-005453-4057qib7 10744 14 / / SYM cord-005453-4057qib7 10744 15 kg kg NN cord-005453-4057qib7 10744 16 ) ) -RRB- cord-005453-4057qib7 10744 17 every every DT cord-005453-4057qib7 10744 18 12 12 CD cord-005453-4057qib7 10744 19 hours hour NNS cord-005453-4057qib7 10744 20 before before RB cord-005453-4057qib7 10744 21 and and CC cord-005453-4057qib7 10744 22 during during IN cord-005453-4057qib7 10744 23 the the DT cord-005453-4057qib7 10744 24 conditioning conditioning NN cord-005453-4057qib7 10744 25 regimen regimen NN cord-005453-4057qib7 10744 26 has have VBZ cord-005453-4057qib7 10744 27 allowed allow VBN cord-005453-4057qib7 10744 28 a a DT cord-005453-4057qib7 10744 29 better well JJR cord-005453-4057qib7 10744 30 control control NN cord-005453-4057qib7 10744 31 of of IN cord-005453-4057qib7 10744 32 viral viral JJ cord-005453-4057qib7 10744 33 reactivation reactivation NN cord-005453-4057qib7 10744 34 . . . cord-005453-4057qib7 10745 1 Conclusions conclusion NNS cord-005453-4057qib7 10745 2 : : : cord-005453-4057qib7 10746 1 The the DT cord-005453-4057qib7 10746 2 attempts attempt NNS cord-005453-4057qib7 10746 3 to to TO cord-005453-4057qib7 10746 4 improve improve VB cord-005453-4057qib7 10746 5 immune immune JJ cord-005453-4057qib7 10746 6 function function NN cord-005453-4057qib7 10746 7 and and CC cord-005453-4057qib7 10746 8 reduce reduce VB cord-005453-4057qib7 10746 9 nonrelapse nonrelapse JJ cord-005453-4057qib7 10746 10 mortality mortality NN cord-005453-4057qib7 10746 11 from from IN cord-005453-4057qib7 10746 12 infectious infectious JJ cord-005453-4057qib7 10746 13 complications complication NNS cord-005453-4057qib7 10746 14 without without IN cord-005453-4057qib7 10746 15 increasing increase VBG cord-005453-4057qib7 10746 16 GvHD GvHD NNP cord-005453-4057qib7 10746 17 have have VBP cord-005453-4057qib7 10746 18 focused focus VBN cord-005453-4057qib7 10746 19 on on IN cord-005453-4057qib7 10746 20 a a DT cord-005453-4057qib7 10746 21 partial partial JJ cord-005453-4057qib7 10746 22 T t NN cord-005453-4057qib7 10746 23 cell cell NN cord-005453-4057qib7 10746 24 depleted deplete VBN cord-005453-4057qib7 10746 25 graft graft NN cord-005453-4057qib7 10746 26 , , , cord-005453-4057qib7 10746 27 such such JJ cord-005453-4057qib7 10746 28 as as IN cord-005453-4057qib7 10746 29 T T NNP cord-005453-4057qib7 10746 30 cell cell NN cord-005453-4057qib7 10746 31 depletion depletion NN cord-005453-4057qib7 10746 32 ( ( -LRB- cord-005453-4057qib7 10746 33 TCR TCR NNP cord-005453-4057qib7 10746 34 α α NNP cord-005453-4057qib7 10746 35 / / SYM cord-005453-4057qib7 10746 36 β β NN cord-005453-4057qib7 10746 37 ) ) -RRB- cord-005453-4057qib7 10746 38 . . . cord-005453-4057qib7 10747 1 This this DT cord-005453-4057qib7 10747 2 graft graft NN cord-005453-4057qib7 10747 3 retains retain VBZ cord-005453-4057qib7 10747 4 a a DT cord-005453-4057qib7 10747 5 large large JJ cord-005453-4057qib7 10747 6 numbers number NNS cord-005453-4057qib7 10747 7 of of IN cord-005453-4057qib7 10747 8 effector effector NN cord-005453-4057qib7 10747 9 cells cell NNS cord-005453-4057qib7 10747 10 , , , cord-005453-4057qib7 10747 11 such such JJ cord-005453-4057qib7 10747 12 as as IN cord-005453-4057qib7 10747 13 TcR TcR NNP cord-005453-4057qib7 10747 14 γ γ NNP cord-005453-4057qib7 10747 15 / / SYM cord-005453-4057qib7 10747 16 δ δ NN cord-005453-4057qib7 10747 17 and and CC cord-005453-4057qib7 10747 18 natural natural JJ cord-005453-4057qib7 10747 19 killer killer NN cord-005453-4057qib7 10747 20 cells cell NNS cord-005453-4057qib7 10747 21 . . . cord-005453-4057qib7 10748 1 However however RB cord-005453-4057qib7 10748 2 , , , cord-005453-4057qib7 10748 3 delayed delay VBN cord-005453-4057qib7 10748 4 immune immune JJ cord-005453-4057qib7 10748 5 reconstitution reconstitution NN cord-005453-4057qib7 10748 6 and and CC cord-005453-4057qib7 10748 7 subsequent subsequent JJ cord-005453-4057qib7 10748 8 infections infection NNS cord-005453-4057qib7 10748 9 are be VBP cord-005453-4057qib7 10748 10 a a DT cord-005453-4057qib7 10748 11 big big JJ cord-005453-4057qib7 10748 12 issue issue NN cord-005453-4057qib7 10748 13 . . . cord-005453-4057qib7 10749 1 A a DT cord-005453-4057qib7 10749 2 novel novel JJ cord-005453-4057qib7 10749 3 partial partial JJ cord-005453-4057qib7 10749 4 T t NN cord-005453-4057qib7 10749 5 cell cell NN cord-005453-4057qib7 10749 6 depletion depletion NN cord-005453-4057qib7 10749 7 strategy strategy NN cord-005453-4057qib7 10749 8 such such JJ cord-005453-4057qib7 10749 9 as as IN cord-005453-4057qib7 10749 10 depleted deplete VBN cord-005453-4057qib7 10749 11 naïve naïve JJ cord-005453-4057qib7 10749 12 T t NN cord-005453-4057qib7 10749 13 cells cell NNS cord-005453-4057qib7 10749 14 ( ( -LRB- cord-005453-4057qib7 10749 15 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 10749 16 T T NNP cord-005453-4057qib7 10749 17 cells cell NNS cord-005453-4057qib7 10749 18 ) ) -RRB- cord-005453-4057qib7 10749 19 could could MD cord-005453-4057qib7 10749 20 enhance enhance VB cord-005453-4057qib7 10749 21 the the DT cord-005453-4057qib7 10749 22 recovery recovery NN cord-005453-4057qib7 10749 23 of of IN cord-005453-4057qib7 10749 24 immune immune JJ cord-005453-4057qib7 10749 25 function function NN cord-005453-4057qib7 10749 26 after after IN cord-005453-4057qib7 10749 27 haplo haplo NN cord-005453-4057qib7 10749 28 - - HYPH cord-005453-4057qib7 10749 29 HSCT HSCT NNP cord-005453-4057qib7 10749 30 because because IN cord-005453-4057qib7 10749 31 donor donor NN cord-005453-4057qib7 10749 32 pathogen pathogen NN cord-005453-4057qib7 10749 33 memory memory NN cord-005453-4057qib7 10749 34 T T NNP cord-005453-4057qib7 10749 35 cells cell NNS cord-005453-4057qib7 10749 36 from from IN cord-005453-4057qib7 10749 37 the the DT cord-005453-4057qib7 10749 38 donor donor NN cord-005453-4057qib7 10749 39 are be VBP cord-005453-4057qib7 10749 40 retained retain VBN cord-005453-4057qib7 10749 41 . . . cord-005453-4057qib7 10750 1 It -PRON- PRP cord-005453-4057qib7 10750 2 is be VBZ cord-005453-4057qib7 10750 3 necessary necessary JJ cord-005453-4057qib7 10750 4 to to TO cord-005453-4057qib7 10750 5 increase increase VB cord-005453-4057qib7 10750 6 the the DT cord-005453-4057qib7 10750 7 studies study NNS cord-005453-4057qib7 10750 8 and and CC cord-005453-4057qib7 10750 9 the the DT cord-005453-4057qib7 10750 10 database database NN cord-005453-4057qib7 10750 11 to to TO cord-005453-4057qib7 10750 12 set set VB cord-005453-4057qib7 10750 13 the the DT cord-005453-4057qib7 10750 14 scheme scheme NN cord-005453-4057qib7 10750 15 of of IN cord-005453-4057qib7 10750 16 previous previous JJ cord-005453-4057qib7 10750 17 prophylaxis prophylaxis NN cord-005453-4057qib7 10750 18 to to IN cord-005453-4057qib7 10750 19 the the DT cord-005453-4057qib7 10750 20 recipient recipient NN cord-005453-4057qib7 10750 21 to to TO cord-005453-4057qib7 10750 22 contain contain VB cord-005453-4057qib7 10750 23 the the DT cord-005453-4057qib7 10750 24 viral viral JJ cord-005453-4057qib7 10750 25 reactivation reactivation NN cord-005453-4057qib7 10750 26 and and CC cord-005453-4057qib7 10750 27 to to TO cord-005453-4057qib7 10750 28 help help VB cord-005453-4057qib7 10750 29 a a DT cord-005453-4057qib7 10750 30 rapid rapid JJ cord-005453-4057qib7 10750 31 immune immune JJ cord-005453-4057qib7 10750 32 reconstitution reconstitution NN cord-005453-4057qib7 10750 33 . . . cord-005453-4057qib7 10751 1 Disclosure disclosure NN cord-005453-4057qib7 10751 2 : : : cord-005453-4057qib7 10751 3 No no DT cord-005453-4057qib7 10751 4 conflict conflict NN cord-005453-4057qib7 10751 5 of of IN cord-005453-4057qib7 10751 6 interest interest NN cord-005453-4057qib7 10751 7 is be VBZ cord-005453-4057qib7 10751 8 declared declare VBN cord-005453-4057qib7 10751 9 Information Information NNP cord-005453-4057qib7 10751 10 was be VBD cord-005453-4057qib7 10751 11 recovered recover VBN cord-005453-4057qib7 10751 12 from from IN cord-005453-4057qib7 10751 13 the the DT cord-005453-4057qib7 10751 14 medical medical JJ cord-005453-4057qib7 10751 15 records record NNS cord-005453-4057qib7 10751 16 . . . cord-005453-4057qib7 10752 1 Results result NNS cord-005453-4057qib7 10752 2 : : : cord-005453-4057qib7 10753 1 Thirty thirty CD cord-005453-4057qib7 10753 2 - - HYPH cord-005453-4057qib7 10753 3 four four CD cord-005453-4057qib7 10753 4 patients patient NNS cord-005453-4057qib7 10753 5 were be VBD cord-005453-4057qib7 10753 6 included include VBN cord-005453-4057qib7 10753 7 , , , cord-005453-4057qib7 10753 8 of of IN cord-005453-4057qib7 10753 9 them -PRON- PRP cord-005453-4057qib7 10753 10 with with IN cord-005453-4057qib7 10753 11 the the DT cord-005453-4057qib7 10753 12 following follow VBG cord-005453-4057qib7 10753 13 diagnoses diagnosis NNS cord-005453-4057qib7 10753 14 : : : cord-005453-4057qib7 10753 15 Acute acute JJ cord-005453-4057qib7 10753 16 leukemia leukemia NN cord-005453-4057qib7 10753 17 ( ( -LRB- cord-005453-4057qib7 10753 18 27 27 CD cord-005453-4057qib7 10753 19 ) ) -RRB- cord-005453-4057qib7 10753 20 , , , cord-005453-4057qib7 10753 21 granulocytic granulocytic JJ cord-005453-4057qib7 10753 22 chronic chronic JJ cord-005453-4057qib7 10753 23 leukemia leukemia NN cord-005453-4057qib7 10753 24 ( ( -LRB- cord-005453-4057qib7 10753 25 4 4 CD cord-005453-4057qib7 10753 26 ) ) -RRB- cord-005453-4057qib7 10753 27 , , , cord-005453-4057qib7 10753 28 dendritic dendritic JJ cord-005453-4057qib7 10753 29 cell cell NN cord-005453-4057qib7 10753 30 neoplasia neoplasia NN cord-005453-4057qib7 10753 31 ( ( -LRB- cord-005453-4057qib7 10753 32 2 2 CD cord-005453-4057qib7 10753 33 ) ) -RRB- cord-005453-4057qib7 10753 34 , , , cord-005453-4057qib7 10753 35 aplastic aplastic JJ cord-005453-4057qib7 10753 36 anemia anemia NN cord-005453-4057qib7 10753 37 ( ( -LRB- cord-005453-4057qib7 10753 38 1 1 CD cord-005453-4057qib7 10753 39 ) ) -RRB- cord-005453-4057qib7 10753 40 . . . cord-005453-4057qib7 10754 1 80 80 CD cord-005453-4057qib7 10754 2 % % NN cord-005453-4057qib7 10754 3 of of IN cord-005453-4057qib7 10754 4 the the DT cord-005453-4057qib7 10754 5 patients patient NNS cord-005453-4057qib7 10754 6 received receive VBD cord-005453-4057qib7 10754 7 a a DT cord-005453-4057qib7 10754 8 transplant transplant NN cord-005453-4057qib7 10754 9 from from IN cord-005453-4057qib7 10754 10 an an DT cord-005453-4057qib7 10754 11 identical identical JJ cord-005453-4057qib7 10754 12 HLA HLA NNP cord-005453-4057qib7 10754 13 donor donor NN cord-005453-4057qib7 10754 14 and and CC cord-005453-4057qib7 10754 15 20 20 CD cord-005453-4057qib7 10754 16 % % NN cord-005453-4057qib7 10754 17 received receive VBD cord-005453-4057qib7 10754 18 a a DT cord-005453-4057qib7 10754 19 haploidentical haploidentical JJ cord-005453-4057qib7 10754 20 transplant transplant NN cord-005453-4057qib7 10754 21 . . . cord-005453-4057qib7 10755 1 Mean mean JJ cord-005453-4057qib7 10755 2 age age NN cord-005453-4057qib7 10755 3 's 's POS cord-005453-4057qib7 10755 4 patients patient NNS cord-005453-4057qib7 10755 5 was be VBD cord-005453-4057qib7 10755 6 32 32 CD cord-005453-4057qib7 10755 7 years year NNS cord-005453-4057qib7 10755 8 ( ( -LRB- cord-005453-4057qib7 10755 9 19 19 CD cord-005453-4057qib7 10755 10 - - SYM cord-005453-4057qib7 10755 11 57 57 CD cord-005453-4057qib7 10755 12 ) ) -RRB- cord-005453-4057qib7 10755 13 . . . cord-005453-4057qib7 10756 1 Prophylaxis Prophylaxis NNP cord-005453-4057qib7 10756 2 with with IN cord-005453-4057qib7 10756 3 Posaconazole Posaconazole NNP cord-005453-4057qib7 10756 4 was be VBD cord-005453-4057qib7 10756 5 performed perform VBN cord-005453-4057qib7 10756 6 on on IN cord-005453-4057qib7 10756 7 44 44 CD cord-005453-4057qib7 10756 8 % % NN cord-005453-4057qib7 10756 9 of of IN cord-005453-4057qib7 10756 10 the the DT cord-005453-4057qib7 10756 11 patients patient NNS cord-005453-4057qib7 10756 12 with with IN cord-005453-4057qib7 10756 13 identical identical JJ cord-005453-4057qib7 10756 14 HLA HLA NNP cord-005453-4057qib7 10756 15 and and CC cord-005453-4057qib7 10756 16 86 86 CD cord-005453-4057qib7 10756 17 % % NN cord-005453-4057qib7 10756 18 on on IN cord-005453-4057qib7 10756 19 haploidentical haploidentical JJ cord-005453-4057qib7 10756 20 group group NN cord-005453-4057qib7 10756 21 ; ; : cord-005453-4057qib7 10756 22 the the DT cord-005453-4057qib7 10756 23 rest rest NN cord-005453-4057qib7 10756 24 of of IN cord-005453-4057qib7 10756 25 the the DT cord-005453-4057qib7 10756 26 patients patient NNS cord-005453-4057qib7 10756 27 received receive VBD cord-005453-4057qib7 10756 28 Fluconazole Fluconazole NNP cord-005453-4057qib7 10756 29 . . . cord-005453-4057qib7 10757 1 The the DT cord-005453-4057qib7 10757 2 posaconazole posaconazole NN cord-005453-4057qib7 10757 3 group group NN cord-005453-4057qib7 10757 4 presented present VBD cord-005453-4057qib7 10757 5 : : : cord-005453-4057qib7 10757 6 Fever fever NN cord-005453-4057qib7 10757 7 61 61 CD cord-005453-4057qib7 10757 8 % % NN cord-005453-4057qib7 10757 9 , , , cord-005453-4057qib7 10757 10 mucositis mucositis NNP cord-005453-4057qib7 10757 11 GI GI NNP cord-005453-4057qib7 10757 12 - - HYPH cord-005453-4057qib7 10757 13 II II NNP cord-005453-4057qib7 10757 14 94 94 CD cord-005453-4057qib7 10757 15 % % NN cord-005453-4057qib7 10757 16 , , , cord-005453-4057qib7 10757 17 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 10757 18 toxicity toxicity NN cord-005453-4057qib7 10757 19 GI GI NNP cord-005453-4057qib7 10757 20 - - HYPH cord-005453-4057qib7 10757 21 II II NNP cord-005453-4057qib7 10757 22 67 67 CD cord-005453-4057qib7 10757 23 % % NN cord-005453-4057qib7 10757 24 ( ( -LRB- cord-005453-4057qib7 10757 25 p= p= NNP cord-005453-4057qib7 10757 26 0.006 0.006 CD cord-005453-4057qib7 10757 27 ) ) -RRB- cord-005453-4057qib7 10757 28 , , , cord-005453-4057qib7 10757 29 hepatic hepatic JJ cord-005453-4057qib7 10757 30 toxicity toxicity NN cord-005453-4057qib7 10757 31 11 11 CD cord-005453-4057qib7 10757 32 % % NN cord-005453-4057qib7 10757 33 , , , cord-005453-4057qib7 10757 34 kidney kidney NN cord-005453-4057qib7 10757 35 toxicity toxicity NN cord-005453-4057qib7 10757 36 17 17 CD cord-005453-4057qib7 10757 37 % % NN cord-005453-4057qib7 10757 38 , , , cord-005453-4057qib7 10757 39 oral oral JJ cord-005453-4057qib7 10757 40 candidiasis candidiasis NN cord-005453-4057qib7 10757 41 100 100 CD cord-005453-4057qib7 10757 42 % % NN cord-005453-4057qib7 10757 43 . . . cord-005453-4057qib7 10758 1 During during IN cord-005453-4057qib7 10758 2 this this DT cord-005453-4057qib7 10758 3 period period NN cord-005453-4057qib7 10758 4 none none NN cord-005453-4057qib7 10758 5 of of IN cord-005453-4057qib7 10758 6 the the DT cord-005453-4057qib7 10758 7 patients patient NNS cord-005453-4057qib7 10758 8 presented present VBD cord-005453-4057qib7 10758 9 invasive invasive JJ cord-005453-4057qib7 10758 10 fungal fungal JJ cord-005453-4057qib7 10758 11 infection infection NN cord-005453-4057qib7 10758 12 in in IN cord-005453-4057qib7 10758 13 any any DT cord-005453-4057qib7 10758 14 group group NN cord-005453-4057qib7 10758 15 . . . cord-005453-4057qib7 10759 1 There there EX cord-005453-4057qib7 10759 2 were be VBD cord-005453-4057qib7 10759 3 2 2 CD cord-005453-4057qib7 10759 4 deceases decease NNS cord-005453-4057qib7 10759 5 , , , cord-005453-4057qib7 10759 6 one one CD cord-005453-4057qib7 10759 7 on on IN cord-005453-4057qib7 10759 8 each each DT cord-005453-4057qib7 10759 9 group group NN cord-005453-4057qib7 10759 10 and and CC cord-005453-4057qib7 10759 11 none none NN cord-005453-4057qib7 10759 12 related relate VBN cord-005453-4057qib7 10759 13 to to IN cord-005453-4057qib7 10759 14 a a DT cord-005453-4057qib7 10759 15 fungal fungal JJ cord-005453-4057qib7 10759 16 infection infection NN cord-005453-4057qib7 10759 17 . . . cord-005453-4057qib7 10760 1 The the DT cord-005453-4057qib7 10760 2 overall overall JJ cord-005453-4057qib7 10760 3 survival survival NN cord-005453-4057qib7 10760 4 was be VBD cord-005453-4057qib7 10760 5 of of IN cord-005453-4057qib7 10760 6 the the DT cord-005453-4057qib7 10760 7 92 92 CD cord-005453-4057qib7 10760 8 % % NN cord-005453-4057qib7 10760 9 versus versus IN cord-005453-4057qib7 10760 10 93 93 CD cord-005453-4057qib7 10760 11 % % NN cord-005453-4057qib7 10760 12 on on IN cord-005453-4057qib7 10760 13 the the DT cord-005453-4057qib7 10760 14 posaconazole posaconazole NNP cord-005453-4057qib7 10760 15 group group NN cord-005453-4057qib7 10760 16 and and CC cord-005453-4057qib7 10760 17 the the DT cord-005453-4057qib7 10760 18 fluconazole fluconazole NNP cord-005453-4057qib7 10760 19 group group NN cord-005453-4057qib7 10760 20 respectively respectively RB cord-005453-4057qib7 10760 21 . . . cord-005453-4057qib7 10761 1 Conclusions conclusion NNS cord-005453-4057qib7 10761 2 : : : cord-005453-4057qib7 10762 1 The the DT cord-005453-4057qib7 10762 2 prophylaxis prophylaxis NN cord-005453-4057qib7 10762 3 with with IN cord-005453-4057qib7 10762 4 posaconazole posaconazole NNP cord-005453-4057qib7 10762 5 and and CC cord-005453-4057qib7 10762 6 fluconazole fluconazole NNP cord-005453-4057qib7 10762 7 is be VBZ cord-005453-4057qib7 10762 8 effective effective JJ cord-005453-4057qib7 10762 9 on on IN cord-005453-4057qib7 10762 10 the the DT cord-005453-4057qib7 10762 11 prevention prevention NN cord-005453-4057qib7 10762 12 of of IN cord-005453-4057qib7 10762 13 invasive invasive JJ cord-005453-4057qib7 10762 14 fungal fungal JJ cord-005453-4057qib7 10762 15 infection infection NN cord-005453-4057qib7 10762 16 on on IN cord-005453-4057qib7 10762 17 the the DT cord-005453-4057qib7 10762 18 first first JJ cord-005453-4057qib7 10762 19 100 100 CD cord-005453-4057qib7 10762 20 days day NNS cord-005453-4057qib7 10762 21 . . . cord-005453-4057qib7 10763 1 The the DT cord-005453-4057qib7 10763 2 toxicity toxicity NN cord-005453-4057qib7 10763 3 was be VBD cord-005453-4057qib7 10763 4 similar similar JJ cord-005453-4057qib7 10763 5 on on IN cord-005453-4057qib7 10763 6 both both DT cord-005453-4057qib7 10763 7 groups group NNS cord-005453-4057qib7 10763 8 . . . cord-005453-4057qib7 10764 1 Posaconazole Posaconazole NNP cord-005453-4057qib7 10764 2 can can MD cord-005453-4057qib7 10764 3 be be VB cord-005453-4057qib7 10764 4 effective effective JJ cord-005453-4057qib7 10764 5 on on IN cord-005453-4057qib7 10764 6 the the DT cord-005453-4057qib7 10764 7 prevention prevention NN cord-005453-4057qib7 10764 8 of of IN cord-005453-4057qib7 10764 9 the the DT cord-005453-4057qib7 10764 10 haploidentical haploidentical JJ cord-005453-4057qib7 10764 11 type type NN cord-005453-4057qib7 10764 12 . . . cord-005453-4057qib7 10765 1 Is be VBZ cord-005453-4057qib7 10765 2 necessary necessary JJ cord-005453-4057qib7 10765 3 to to TO cord-005453-4057qib7 10765 4 continue continue VB cord-005453-4057qib7 10765 5 following follow VBG cord-005453-4057qib7 10765 6 the the DT cord-005453-4057qib7 10765 7 patients patient NNS cord-005453-4057qib7 10765 8 with with IN cord-005453-4057qib7 10765 9 infection infection NN cord-005453-4057qib7 10765 10 risk risk NN cord-005453-4057qib7 10765 11 on on IN cord-005453-4057qib7 10765 12 a a DT cord-005453-4057qib7 10765 13 long long JJ cord-005453-4057qib7 10765 14 - - HYPH cord-005453-4057qib7 10765 15 term term NN cord-005453-4057qib7 10765 16 period period NN cord-005453-4057qib7 10765 17 associated associate VBN cord-005453-4057qib7 10765 18 with with IN cord-005453-4057qib7 10765 19 the the DT cord-005453-4057qib7 10765 20 chronic chronic JJ cord-005453-4057qib7 10765 21 GVHD GVHD NNP cord-005453-4057qib7 10765 22 . . . cord-005453-4057qib7 10766 1 Disclosure disclosure NN cord-005453-4057qib7 10766 2 : : : cord-005453-4057qib7 10767 1 None none NN cord-005453-4057qib7 10767 2 declared declare VBD cord-005453-4057qib7 10767 3 Lymphoma Lymphoma NNP cord-005453-4057qib7 10768 1 These these DT cord-005453-4057qib7 10768 2 results result NNS cord-005453-4057qib7 10768 3 open open VBP cord-005453-4057qib7 10768 4 the the DT cord-005453-4057qib7 10768 5 question question NN cord-005453-4057qib7 10768 6 whether whether IN cord-005453-4057qib7 10768 7 allo allo NN cord-005453-4057qib7 10768 8 - - HYPH cord-005453-4057qib7 10768 9 SCT SCT NNP cord-005453-4057qib7 10768 10 should should MD cord-005453-4057qib7 10768 11 still still RB cord-005453-4057qib7 10768 12 be be VB cord-005453-4057qib7 10768 13 offered offer VBN cord-005453-4057qib7 10768 14 to to IN cord-005453-4057qib7 10768 15 these these DT cord-005453-4057qib7 10768 16 patients patient NNS cord-005453-4057qib7 10768 17 . . . cord-005453-4057qib7 10769 1 Methods method NNS cord-005453-4057qib7 10769 2 : : : cord-005453-4057qib7 10769 3 We -PRON- PRP cord-005453-4057qib7 10769 4 aimed aim VBD cord-005453-4057qib7 10769 5 to to TO cord-005453-4057qib7 10769 6 define define VB cord-005453-4057qib7 10769 7 the the DT cord-005453-4057qib7 10769 8 role role NN cord-005453-4057qib7 10769 9 of of IN cord-005453-4057qib7 10769 10 allo allo NNP cord-005453-4057qib7 10769 11 - - HYPH cord-005453-4057qib7 10769 12 SCT SCT NNP cord-005453-4057qib7 10769 13 in in IN cord-005453-4057qib7 10769 14 refractory refractory JJ cord-005453-4057qib7 10769 15 or or CC cord-005453-4057qib7 10769 16 relapsing relapse VBG cord-005453-4057qib7 10769 17 after after IN cord-005453-4057qib7 10769 18 two two CD cord-005453-4057qib7 10769 19 lines line NNS cord-005453-4057qib7 10769 20 de de IN cord-005453-4057qib7 10769 21 novo novo NNP cord-005453-4057qib7 10769 22 or or CC cord-005453-4057qib7 10769 23 transformed transform VBN cord-005453-4057qib7 10769 24 DLBCL DLBCL NNP cord-005453-4057qib7 10769 25 patients patient NNS cord-005453-4057qib7 10769 26 , , , cord-005453-4057qib7 10769 27 and and CC cord-005453-4057qib7 10769 28 its -PRON- PRP$ cord-005453-4057qib7 10769 29 comparison comparison NN cord-005453-4057qib7 10769 30 with with IN cord-005453-4057qib7 10769 31 ZUMA-1 ZUMA-1 NNP cord-005453-4057qib7 10769 32 CAR CAR NNP cord-005453-4057qib7 10769 33 - - HYPH cord-005453-4057qib7 10769 34 T t NN cord-005453-4057qib7 10769 35 cells cell NNS cord-005453-4057qib7 10769 36 trial trial NN cord-005453-4057qib7 10769 37 ( ( -LRB- cord-005453-4057qib7 10769 38 Neelapu Neelapu NNP cord-005453-4057qib7 10769 39 et et NNP cord-005453-4057qib7 10769 40 al al NNP cord-005453-4057qib7 10769 41 NEJM NEJM NNP cord-005453-4057qib7 10769 42 2017 2017 CD cord-005453-4057qib7 10769 43 ) ) -RRB- cord-005453-4057qib7 10769 44 . . . cord-005453-4057qib7 10770 1 We -PRON- PRP cord-005453-4057qib7 10770 2 analyse analyse VBP cord-005453-4057qib7 10770 3 long long JJ cord-005453-4057qib7 10770 4 - - HYPH cord-005453-4057qib7 10770 5 term term NN cord-005453-4057qib7 10770 6 allo allo NN cord-005453-4057qib7 10770 7 - - HYPH cord-005453-4057qib7 10770 8 SCT SCT NNP cord-005453-4057qib7 10770 9 results result NNS cord-005453-4057qib7 10770 10 in in IN cord-005453-4057qib7 10770 11 40 40 CD cord-005453-4057qib7 10770 12 de de NNP cord-005453-4057qib7 10770 13 novo novo NNP cord-005453-4057qib7 10770 14 ( ( -LRB- cord-005453-4057qib7 10770 15 n=23 n=23 NNP cord-005453-4057qib7 10770 16 ) ) -RRB- cord-005453-4057qib7 10770 17 or or CC cord-005453-4057qib7 10770 18 transformed transform VBN cord-005453-4057qib7 10770 19 DLBCL DLBCL NNP cord-005453-4057qib7 10770 20 ( ( -LRB- cord-005453-4057qib7 10770 21 n=17 n=17 NNP cord-005453-4057qib7 10770 22 ) ) -RRB- cord-005453-4057qib7 10770 23 out out IN cord-005453-4057qib7 10770 24 of of IN cord-005453-4057qib7 10770 25 the the DT cord-005453-4057qib7 10770 26 1000 1000 CD cord-005453-4057qib7 10770 27 allo allo NN cord-005453-4057qib7 10770 28 - - HYPH cord-005453-4057qib7 10770 29 SCT SCT NNP cord-005453-4057qib7 10770 30 performed perform VBN cord-005453-4057qib7 10770 31 in in IN cord-005453-4057qib7 10770 32 our -PRON- PRP$ cord-005453-4057qib7 10770 33 institution institution NN cord-005453-4057qib7 10770 34 between between IN cord-005453-4057qib7 10770 35 October October NNP cord-005453-4057qib7 10770 36 1995 1995 CD cord-005453-4057qib7 10770 37 to to IN cord-005453-4057qib7 10770 38 October October NNP cord-005453-4057qib7 10770 39 2018 2018 CD cord-005453-4057qib7 10770 40 . . . cord-005453-4057qib7 10771 1 Results result NNS cord-005453-4057qib7 10771 2 : : : cord-005453-4057qib7 10772 1 Patients patient NNS cord-005453-4057qib7 10772 2 and and CC cord-005453-4057qib7 10772 3 transplant transplant NN cord-005453-4057qib7 10772 4 characteristics characteristic NNS cord-005453-4057qib7 10772 5 are be VBP cord-005453-4057qib7 10772 6 summarized summarize VBN cord-005453-4057qib7 10772 7 in in IN cord-005453-4057qib7 10772 8 Table Table NNP cord-005453-4057qib7 10772 9 1 1 CD cord-005453-4057qib7 10772 10 . . . cord-005453-4057qib7 10773 1 Complete complete JJ cord-005453-4057qib7 10773 2 response response NN cord-005453-4057qib7 10773 3 ( ( -LRB- cord-005453-4057qib7 10773 4 CR cr NN cord-005453-4057qib7 10773 5 ) ) -RRB- cord-005453-4057qib7 10773 6 at at IN cord-005453-4057qib7 10773 7 100 100 CD cord-005453-4057qib7 10773 8 days day NNS cord-005453-4057qib7 10773 9 was be VBD cord-005453-4057qib7 10773 10 67,5 67,5 CD cord-005453-4057qib7 10773 11 % % NN cord-005453-4057qib7 10773 12 and and CC cord-005453-4057qib7 10773 13 83 83 CD cord-005453-4057qib7 10773 14 % % NN cord-005453-4057qib7 10773 15 of of IN cord-005453-4057qib7 10773 16 them -PRON- PRP cord-005453-4057qib7 10773 17 remain remain VBP cord-005453-4057qib7 10773 18 in in IN cord-005453-4057qib7 10773 19 CR CR NNP cord-005453-4057qib7 10773 20 at at IN cord-005453-4057qib7 10773 21 12 12 CD cord-005453-4057qib7 10773 22 months month NNS cord-005453-4057qib7 10773 23 . . . cord-005453-4057qib7 10774 1 With with IN cord-005453-4057qib7 10774 2 a a DT cord-005453-4057qib7 10774 3 median median JJ cord-005453-4057qib7 10774 4 follow follow NN cord-005453-4057qib7 10774 5 - - HYPH cord-005453-4057qib7 10774 6 up up NN cord-005453-4057qib7 10774 7 of of IN cord-005453-4057qib7 10774 8 46 46 CD cord-005453-4057qib7 10774 9 months month NNS cord-005453-4057qib7 10774 10 , , , cord-005453-4057qib7 10774 11 5-year 5-year CD cord-005453-4057qib7 10774 12 progression progression NN cord-005453-4057qib7 10774 13 - - HYPH cord-005453-4057qib7 10774 14 free free JJ cord-005453-4057qib7 10774 15 survival survival NN cord-005453-4057qib7 10774 16 ( ( -LRB- cord-005453-4057qib7 10774 17 PFS PFS NNP cord-005453-4057qib7 10774 18 ) ) -RRB- cord-005453-4057qib7 10774 19 was be VBD cord-005453-4057qib7 10774 20 54 54 CD cord-005453-4057qib7 10774 21 % % NN cord-005453-4057qib7 10774 22 and and CC cord-005453-4057qib7 10774 23 5-year 5-year CD cord-005453-4057qib7 10774 24 overall overall JJ cord-005453-4057qib7 10774 25 survival survival NN cord-005453-4057qib7 10774 26 ( ( -LRB- cord-005453-4057qib7 10774 27 OS OS NNP cord-005453-4057qib7 10774 28 ) ) -RRB- cord-005453-4057qib7 10774 29 48 48 CD cord-005453-4057qib7 10774 30 % % NN cord-005453-4057qib7 10774 31 , , , cord-005453-4057qib7 10774 32 with with IN cord-005453-4057qib7 10774 33 a a DT cord-005453-4057qib7 10774 34 3-year 3-year CD cord-005453-4057qib7 10774 35 transplant transplant NN cord-005453-4057qib7 10774 36 - - HYPH cord-005453-4057qib7 10774 37 related relate VBN cord-005453-4057qib7 10774 38 mortality mortality NN cord-005453-4057qib7 10774 39 of of IN cord-005453-4057qib7 10774 40 18 18 CD cord-005453-4057qib7 10774 41 % % NN cord-005453-4057qib7 10774 42 . . . cord-005453-4057qib7 10775 1 Refractoriness Refractoriness NNP cord-005453-4057qib7 10775 2 at at IN cord-005453-4057qib7 10775 3 the the DT cord-005453-4057qib7 10775 4 time time NN cord-005453-4057qib7 10775 5 of of IN cord-005453-4057qib7 10775 6 the the DT cord-005453-4057qib7 10775 7 transplant transplant NN cord-005453-4057qib7 10775 8 was be VBD cord-005453-4057qib7 10775 9 associated associate VBN cord-005453-4057qib7 10775 10 with with IN cord-005453-4057qib7 10775 11 a a DT cord-005453-4057qib7 10775 12 poorer poor JJR cord-005453-4057qib7 10775 13 prognosis prognosis NN cord-005453-4057qib7 10775 14 , , , cord-005453-4057qib7 10775 15 with with IN cord-005453-4057qib7 10775 16 only only RB cord-005453-4057qib7 10775 17 2 2 CD cord-005453-4057qib7 10775 18 out out IN cord-005453-4057qib7 10775 19 of of IN cord-005453-4057qib7 10775 20 9 9 CD cord-005453-4057qib7 10775 21 refractory refractory JJ cord-005453-4057qib7 10775 22 patients patient NNS cord-005453-4057qib7 10775 23 being be VBG cord-005453-4057qib7 10775 24 long long JJ cord-005453-4057qib7 10775 25 term term NN cord-005453-4057qib7 10775 26 survivors survivor NNS cord-005453-4057qib7 10775 27 ( ( -LRB- cord-005453-4057qib7 10775 28 Figure figure NN cord-005453-4057qib7 10775 29 1 1 CD cord-005453-4057qib7 10775 30 ) ) -RRB- cord-005453-4057qib7 10775 31 . . . cord-005453-4057qib7 10776 1 Similar similar JJ cord-005453-4057qib7 10776 2 results result NNS cord-005453-4057qib7 10776 3 were be VBD cord-005453-4057qib7 10776 4 reported report VBN cord-005453-4057qib7 10776 5 for for IN cord-005453-4057qib7 10776 6 ZUMA-1 zuma-1 CD cord-005453-4057qib7 10776 7 trial trial NN cord-005453-4057qib7 10776 8 , , , cord-005453-4057qib7 10776 9 with with IN cord-005453-4057qib7 10776 10 a a DT cord-005453-4057qib7 10776 11 best good JJS cord-005453-4057qib7 10776 12 response response NN cord-005453-4057qib7 10776 13 of of IN cord-005453-4057qib7 10776 14 55 55 CD cord-005453-4057qib7 10776 15 % % NN cord-005453-4057qib7 10776 16 CR cr NN cord-005453-4057qib7 10776 17 retained retain VBN cord-005453-4057qib7 10776 18 in in IN cord-005453-4057qib7 10776 19 79 79 CD cord-005453-4057qib7 10776 20 % % NN cord-005453-4057qib7 10776 21 of of IN cord-005453-4057qib7 10776 22 them -PRON- PRP cord-005453-4057qib7 10776 23 at at IN cord-005453-4057qib7 10776 24 12 12 CD cord-005453-4057qib7 10776 25 months month NNS cord-005453-4057qib7 10776 26 . . . cord-005453-4057qib7 10777 1 With with IN cord-005453-4057qib7 10777 2 a a DT cord-005453-4057qib7 10777 3 median median JJ cord-005453-4057qib7 10777 4 follow follow NN cord-005453-4057qib7 10777 5 - - HYPH cord-005453-4057qib7 10777 6 up up NN cord-005453-4057qib7 10777 7 of of IN cord-005453-4057qib7 10777 8 15 15 CD cord-005453-4057qib7 10777 9 months month NNS cord-005453-4057qib7 10777 10 , , , cord-005453-4057qib7 10777 11 18-months 18-months CD cord-005453-4057qib7 10777 12 PFS PFS NNP cord-005453-4057qib7 10777 13 was be VBD cord-005453-4057qib7 10777 14 41 41 CD cord-005453-4057qib7 10777 15 % % NN cord-005453-4057qib7 10777 16 and and CC cord-005453-4057qib7 10777 17 18-months 18-months CD cord-005453-4057qib7 10777 18 OS OS NNP cord-005453-4057qib7 10777 19 53 53 CD cord-005453-4057qib7 10777 20 % % NN cord-005453-4057qib7 10777 21 . . . cord-005453-4057qib7 10778 1 Patients patient NNS cord-005453-4057qib7 10778 2 characteristics characteristic NNS cord-005453-4057qib7 10778 3 did do VBD cord-005453-4057qib7 10778 4 not not RB cord-005453-4057qib7 10778 5 differ differ VB cord-005453-4057qib7 10778 6 in in IN cord-005453-4057qib7 10778 7 our -PRON- PRP$ cord-005453-4057qib7 10778 8 series series NN cord-005453-4057qib7 10778 9 and and CC cord-005453-4057qib7 10778 10 ZUMA-1 ZUMA-1 NNP cord-005453-4057qib7 10778 11 , , , cord-005453-4057qib7 10778 12 except except IN cord-005453-4057qib7 10778 13 that that IN cord-005453-4057qib7 10778 14 all all PDT cord-005453-4057qib7 10778 15 the the DT cord-005453-4057qib7 10778 16 patients patient NNS cord-005453-4057qib7 10778 17 in in IN cord-005453-4057qib7 10778 18 ZUMA-1 ZUMA-1 NNP cord-005453-4057qib7 10778 19 were be VBD cord-005453-4057qib7 10778 20 refractory refractory JJ cord-005453-4057qib7 10778 21 prior prior RB cord-005453-4057qib7 10778 22 to to IN cord-005453-4057qib7 10778 23 therapy therapy NN cord-005453-4057qib7 10778 24 ( ( -LRB- cord-005453-4057qib7 10778 25 Table table NN cord-005453-4057qib7 10778 26 1 1 CD cord-005453-4057qib7 10778 27 ) ) -RRB- cord-005453-4057qib7 10778 28 . . . cord-005453-4057qib7 10779 1 Conclusions conclusion NNS cord-005453-4057qib7 10779 2 : : : cord-005453-4057qib7 10780 1 Although although IN cord-005453-4057qib7 10780 2 very very RB cord-005453-4057qib7 10780 3 few few JJ cord-005453-4057qib7 10780 4 patients patient NNS cord-005453-4057qib7 10780 5 with with IN cord-005453-4057qib7 10780 6 de de NNP cord-005453-4057qib7 10780 7 novo novo NNP cord-005453-4057qib7 10780 8 or or CC cord-005453-4057qib7 10780 9 transformed transform VBN cord-005453-4057qib7 10780 10 DLBCL DLBCL NNS cord-005453-4057qib7 10780 11 are be VBP cord-005453-4057qib7 10780 12 offering offer VBG cord-005453-4057qib7 10780 13 an an DT cord-005453-4057qib7 10780 14 allo allo NN cord-005453-4057qib7 10780 15 - - HYPH cord-005453-4057qib7 10780 16 SCT sct NN cord-005453-4057qib7 10780 17 ( ( -LRB- cord-005453-4057qib7 10780 18 4 4 CD cord-005453-4057qib7 10780 19 % % NN cord-005453-4057qib7 10780 20 of of IN cord-005453-4057qib7 10780 21 all all DT cord-005453-4057qib7 10780 22 allo allo NN cord-005453-4057qib7 10780 23 - - HYPH cord-005453-4057qib7 10780 24 SCT SCT NNP cord-005453-4057qib7 10780 25 ) ) -RRB- cord-005453-4057qib7 10780 26 , , , cord-005453-4057qib7 10780 27 this this DT cord-005453-4057qib7 10780 28 is be VBZ cord-005453-4057qib7 10780 29 a a DT cord-005453-4057qib7 10780 30 curative curative JJ cord-005453-4057qib7 10780 31 option option NN cord-005453-4057qib7 10780 32 in in IN cord-005453-4057qib7 10780 33 chemosensitive chemosensitive JJ cord-005453-4057qib7 10780 34 patients patient NNS cord-005453-4057qib7 10780 35 and and CC cord-005453-4057qib7 10780 36 with with IN cord-005453-4057qib7 10780 37 more more RBR cord-005453-4057qib7 10780 38 mature mature JJ cord-005453-4057qib7 10780 39 data datum NNS cord-005453-4057qib7 10780 40 and and CC cord-005453-4057qib7 10780 41 longer long RBR cord-005453-4057qib7 10780 42 follow follow NN cord-005453-4057qib7 10780 43 - - HYPH cord-005453-4057qib7 10780 44 up up NN cord-005453-4057qib7 10780 45 than than IN cord-005453-4057qib7 10780 46 with with IN cord-005453-4057qib7 10780 47 CAR car NN cord-005453-4057qib7 10780 48 - - HYPH cord-005453-4057qib7 10780 49 T t NN cord-005453-4057qib7 10780 50 therapy therapy NN cord-005453-4057qib7 10780 51 ; ; : cord-005453-4057qib7 10780 52 for for IN cord-005453-4057qib7 10780 53 these these DT cord-005453-4057qib7 10780 54 reasons reason NNS cord-005453-4057qib7 10780 55 , , , cord-005453-4057qib7 10780 56 it -PRON- PRP cord-005453-4057qib7 10780 57 should should MD cord-005453-4057qib7 10780 58 still still RB cord-005453-4057qib7 10780 59 be be VB cord-005453-4057qib7 10780 60 offer offer NN cord-005453-4057qib7 10780 61 to to IN cord-005453-4057qib7 10780 62 these these DT cord-005453-4057qib7 10780 63 poor poor JJ cord-005453-4057qib7 10780 64 prognosis prognosis NN cord-005453-4057qib7 10780 65 patients patient NNS cord-005453-4057qib7 10780 66 . . . cord-005453-4057qib7 10781 1 Moreover moreover RB cord-005453-4057qib7 10781 2 , , , cord-005453-4057qib7 10781 3 almost almost RB cord-005453-4057qib7 10781 4 all all DT cord-005453-4057qib7 10781 5 patients patient NNS cord-005453-4057qib7 10781 6 have have VBP cord-005453-4057qib7 10781 7 now now RB cord-005453-4057qib7 10781 8 available available JJ cord-005453-4057qib7 10781 9 donor donor NN cord-005453-4057qib7 10781 10 , , , cord-005453-4057qib7 10781 11 better well JJR cord-005453-4057qib7 10781 12 graft graft NN cord-005453-4057qib7 10781 13 - - HYPH cord-005453-4057qib7 10781 14 versus versus IN cord-005453-4057qib7 10781 15 - - HYPH cord-005453-4057qib7 10781 16 host host NN cord-005453-4057qib7 10781 17 disease disease NN cord-005453-4057qib7 10781 18 prophylaxis prophylaxis NN cord-005453-4057qib7 10781 19 will will MD cord-005453-4057qib7 10781 20 decrease decrease VB cord-005453-4057qib7 10781 21 TRM TRM NNP cord-005453-4057qib7 10781 22 and and CC cord-005453-4057qib7 10781 23 morbidity morbidity NN cord-005453-4057qib7 10781 24 , , , cord-005453-4057qib7 10781 25 and and CC cord-005453-4057qib7 10781 26 new new JJ cord-005453-4057qib7 10781 27 therapies therapy NNS cord-005453-4057qib7 10781 28 will will MD cord-005453-4057qib7 10781 29 make make VB cord-005453-4057qib7 10781 30 more more JJR cord-005453-4057qib7 10781 31 patients patient NNS cord-005453-4057qib7 10781 32 in in IN cord-005453-4057qib7 10781 33 sensitive sensitive JJ cord-005453-4057qib7 10781 34 disease disease NN cord-005453-4057qib7 10781 35 before before IN cord-005453-4057qib7 10781 36 allo allo NNP cord-005453-4057qib7 10781 37 - - HYPH cord-005453-4057qib7 10781 38 SCT SCT NNP cord-005453-4057qib7 10781 39 . . . cord-005453-4057qib7 10782 1 Therefore therefore RB cord-005453-4057qib7 10782 2 , , , cord-005453-4057qib7 10782 3 allo allo NN cord-005453-4057qib7 10782 4 - - HYPH cord-005453-4057qib7 10782 5 SCT SCT NNP cord-005453-4057qib7 10782 6 and and CC cord-005453-4057qib7 10782 7 CAR CAR NNP cord-005453-4057qib7 10782 8 - - HYPH cord-005453-4057qib7 10782 9 T t NN cord-005453-4057qib7 10782 10 cells cell NNS cord-005453-4057qib7 10782 11 are be VBP cord-005453-4057qib7 10782 12 strategies strategy NNS cord-005453-4057qib7 10782 13 to to TO cord-005453-4057qib7 10782 14 be be VB cord-005453-4057qib7 10782 15 discussed discuss VBN cord-005453-4057qib7 10782 16 in in IN cord-005453-4057qib7 10782 17 every every DT cord-005453-4057qib7 10782 18 young young JJ cord-005453-4057qib7 10782 19 patient patient NN cord-005453-4057qib7 10782 20 with with IN cord-005453-4057qib7 10782 21 available available JJ cord-005453-4057qib7 10782 22 donor donor NN cord-005453-4057qib7 10782 23 . . . cord-005453-4057qib7 10783 1 Disclosure disclosure NN cord-005453-4057qib7 10783 2 : : : cord-005453-4057qib7 10783 3 Honoraria Honoraria NNP cord-005453-4057qib7 10783 4 as as IN cord-005453-4057qib7 10783 5 advisor advisor NN cord-005453-4057qib7 10783 6 or or CC cord-005453-4057qib7 10783 7 speaker speaker NN cord-005453-4057qib7 10783 8 from from IN cord-005453-4057qib7 10783 9 Gilead Gilead NNP cord-005453-4057qib7 10784 1 ( ( -LRB- cord-005453-4057qib7 10784 2 Methods method NNS cord-005453-4057qib7 10784 3 : : : cord-005453-4057qib7 10785 1 Consecutive consecutive JJ cord-005453-4057qib7 10785 2 patients patient NNS cord-005453-4057qib7 10785 3 transplanted transplant VBN cord-005453-4057qib7 10785 4 for for IN cord-005453-4057qib7 10785 5 HGBL HGBL NNP cord-005453-4057qib7 10785 6 ( ( -LRB- cord-005453-4057qib7 10785 7 excluding exclude VBG cord-005453-4057qib7 10785 8 Burkitts Burkitts NNP cord-005453-4057qib7 10785 9 lymphoma lymphoma NN cord-005453-4057qib7 10785 10 ) ) -RRB- cord-005453-4057qib7 10785 11 between between IN cord-005453-4057qib7 10785 12 2007 2007 CD cord-005453-4057qib7 10785 13 - - SYM cord-005453-4057qib7 10785 14 2017 2017 CD cord-005453-4057qib7 10785 15 in in IN cord-005453-4057qib7 10785 16 the the DT cord-005453-4057qib7 10785 17 EBMT EBMT NNP cord-005453-4057qib7 10785 18 database database NN cord-005453-4057qib7 10785 19 were be VBD cord-005453-4057qib7 10785 20 included include VBN cord-005453-4057qib7 10785 21 . . . cord-005453-4057qib7 10786 1 Data datum NNS cord-005453-4057qib7 10786 2 collected collect VBD cord-005453-4057qib7 10786 3 included include VBN cord-005453-4057qib7 10786 4 age age NN cord-005453-4057qib7 10786 5 , , , cord-005453-4057qib7 10786 6 sex sex NN cord-005453-4057qib7 10786 7 , , , cord-005453-4057qib7 10786 8 pathology pathology NN cord-005453-4057qib7 10786 9 subtype subtype NN cord-005453-4057qib7 10786 10 ( ( -LRB- cord-005453-4057qib7 10786 11 HGBL HGBL NNP cord-005453-4057qib7 10786 12 ( ( -LRB- cord-005453-4057qib7 10786 13 including include VBG cord-005453-4057qib7 10786 14 subtypes subtype NNS cord-005453-4057qib7 10786 15 ) ) -RRB- cord-005453-4057qib7 10786 16 , , , cord-005453-4057qib7 10786 17 tFL tFL NNP cord-005453-4057qib7 10786 18 , , , cord-005453-4057qib7 10786 19 DHL DHL NNP cord-005453-4057qib7 10786 20 ) ) -RRB- cord-005453-4057qib7 10786 21 , , , cord-005453-4057qib7 10786 22 disease disease NN cord-005453-4057qib7 10786 23 status status NN cord-005453-4057qib7 10786 24 at at IN cord-005453-4057qib7 10786 25 SCT SCT NNP cord-005453-4057qib7 10786 26 , , , cord-005453-4057qib7 10786 27 conditioning conditioning NN cord-005453-4057qib7 10786 28 ( ( -LRB- cord-005453-4057qib7 10786 29 MA MA NNP cord-005453-4057qib7 10786 30 vs vs IN cord-005453-4057qib7 10786 31 BEAM BEAM NNP cord-005453-4057qib7 10786 32 Cam Cam NNP cord-005453-4057qib7 10786 33 vs vs IN cord-005453-4057qib7 10786 34 Flu Flu NNP cord-005453-4057qib7 10786 35 - - HYPH cord-005453-4057qib7 10786 36 Mel Mel NNP cord-005453-4057qib7 10786 37 - - HYPH cord-005453-4057qib7 10786 38 Cam Cam NNP cord-005453-4057qib7 10786 39 / / SYM cord-005453-4057qib7 10786 40 ATG ATG NNP cord-005453-4057qib7 10786 41 ) ) -RRB- cord-005453-4057qib7 10786 42 , , , cord-005453-4057qib7 10786 43 engraftment engraftment NN cord-005453-4057qib7 10786 44 , , , cord-005453-4057qib7 10786 45 day day NN cord-005453-4057qib7 10786 46 100 100 CD cord-005453-4057qib7 10786 47 outcome outcome NN cord-005453-4057qib7 10786 48 , , , cord-005453-4057qib7 10786 49 TRM TRM NNP cord-005453-4057qib7 10786 50 , , , cord-005453-4057qib7 10786 51 OS OS NNP cord-005453-4057qib7 10786 52 and and CC cord-005453-4057qib7 10786 53 PFS PFS NNP cord-005453-4057qib7 10786 54 and and CC cord-005453-4057qib7 10786 55 eligibility eligibility NN cord-005453-4057qib7 10786 56 for for IN cord-005453-4057qib7 10786 57 EMEA EMEA NNP cord-005453-4057qib7 10786 58 licensed licensed JJ cord-005453-4057qib7 10786 59 indication indication NN cord-005453-4057qib7 10786 60 of of IN cord-005453-4057qib7 10786 61 CAR car NN cord-005453-4057qib7 10786 62 - - HYPH cord-005453-4057qib7 10786 63 T t NN cord-005453-4057qib7 10786 64 therapy therapy NN cord-005453-4057qib7 10786 65 . . . cord-005453-4057qib7 10787 1 Results result NNS cord-005453-4057qib7 10787 2 : : : cord-005453-4057qib7 10788 1 Fifty fifty CD cord-005453-4057qib7 10788 2 patients patient NNS cord-005453-4057qib7 10788 3 ( ( -LRB- cord-005453-4057qib7 10788 4 29 29 CD cord-005453-4057qib7 10788 5 M M NNP cord-005453-4057qib7 10788 6 , , , cord-005453-4057qib7 10788 7 21F 21F NNP cord-005453-4057qib7 10788 8 ) ) -RRB- cord-005453-4057qib7 10788 9 with with IN cord-005453-4057qib7 10788 10 a a DT cord-005453-4057qib7 10788 11 median median JJ cord-005453-4057qib7 10788 12 age age NN cord-005453-4057qib7 10788 13 of of IN cord-005453-4057qib7 10788 14 47 47 CD cord-005453-4057qib7 10788 15 at at IN cord-005453-4057qib7 10788 16 diagnosis diagnosis NN cord-005453-4057qib7 10788 17 and and CC cord-005453-4057qib7 10788 18 50 50 CD cord-005453-4057qib7 10788 19 at at IN cord-005453-4057qib7 10788 20 SCT SCT NNP cord-005453-4057qib7 10788 21 were be VBD cord-005453-4057qib7 10788 22 included include VBN cord-005453-4057qib7 10788 23 . . . cord-005453-4057qib7 10789 1 The the DT cord-005453-4057qib7 10789 2 subtypes subtype NNS cord-005453-4057qib7 10789 3 included include VBD cord-005453-4057qib7 10789 4 HGBL HGBL NNP cord-005453-4057qib7 10789 5 ( ( -LRB- cord-005453-4057qib7 10789 6 n=29 n=29 NNP cord-005453-4057qib7 10789 7 ) ) -RRB- cord-005453-4057qib7 10789 8 , , , cord-005453-4057qib7 10789 9 tFL tFL NNP cord-005453-4057qib7 10789 10 ( ( -LRB- cord-005453-4057qib7 10789 11 n=11 n=11 NNP cord-005453-4057qib7 10789 12 ) ) -RRB- cord-005453-4057qib7 10789 13 and and CC cord-005453-4057qib7 10789 14 DHL DHL NNP cord-005453-4057qib7 10789 15 ( ( -LRB- cord-005453-4057qib7 10789 16 n=10 n=10 NNP cord-005453-4057qib7 10789 17 ) ) -RRB- cord-005453-4057qib7 10789 18 . . . cord-005453-4057qib7 10790 1 Indications indication NNS cord-005453-4057qib7 10790 2 for for IN cord-005453-4057qib7 10790 3 SCT SCT NNP cord-005453-4057qib7 10790 4 were be VBD cord-005453-4057qib7 10790 5 : : : cord-005453-4057qib7 10790 6 primary primary JJ cord-005453-4057qib7 10790 7 refractory refractory NN cord-005453-4057qib7 10790 8 ( ( -LRB- cord-005453-4057qib7 10790 9 n=17 n=17 NNP cord-005453-4057qib7 10790 10 ) ) -RRB- cord-005453-4057qib7 10790 11 , , , cord-005453-4057qib7 10790 12 relapse relapse NN cord-005453-4057qib7 10790 13 < < XX cord-005453-4057qib7 10790 14 12 12 CD cord-005453-4057qib7 10790 15 months month NNS cord-005453-4057qib7 10790 16 after after IN cord-005453-4057qib7 10790 17 primary primary JJ cord-005453-4057qib7 10790 18 treatment treatment NN cord-005453-4057qib7 10790 19 ( ( -LRB- cord-005453-4057qib7 10790 20 n=12 n=12 NNP cord-005453-4057qib7 10790 21 ) ) -RRB- cord-005453-4057qib7 10790 22 , , , cord-005453-4057qib7 10790 23 previous previous JJ cord-005453-4057qib7 10790 24 autologous autologous JJ cord-005453-4057qib7 10790 25 - - HYPH cord-005453-4057qib7 10790 26 SCT SCT NNP cord-005453-4057qib7 10790 27 ( ( -LRB- cord-005453-4057qib7 10790 28 n=10 n=10 NNP cord-005453-4057qib7 10790 29 ) ) -RRB- cord-005453-4057qib7 10790 30 and and CC cord-005453-4057qib7 10790 31 DHL DHL NNP cord-005453-4057qib7 10790 32 ( ( -LRB- cord-005453-4057qib7 10790 33 n=11 n=11 NNP cord-005453-4057qib7 10790 34 ) ) -RRB- cord-005453-4057qib7 10790 35 . . . cord-005453-4057qib7 10791 1 The the DT cord-005453-4057qib7 10791 2 median median JJ cord-005453-4057qib7 10791 3 lines line NNS cord-005453-4057qib7 10791 4 of of IN cord-005453-4057qib7 10791 5 therapy therapy NN cord-005453-4057qib7 10791 6 was be VBD cord-005453-4057qib7 10791 7 4 4 CD cord-005453-4057qib7 10792 1 ( ( -LRB- cord-005453-4057qib7 10792 2 range range NN cord-005453-4057qib7 10792 3 1 1 CD cord-005453-4057qib7 10792 4 to to IN cord-005453-4057qib7 10792 5 6 6 CD cord-005453-4057qib7 10792 6 ) ) -RRB- cord-005453-4057qib7 10792 7 . . . cord-005453-4057qib7 10793 1 Conditioning conditioning NN cord-005453-4057qib7 10793 2 used use VBN cord-005453-4057qib7 10793 3 was be VBD cord-005453-4057qib7 10794 1 CyTBI cytbi CD cord-005453-4057qib7 10794 2 n=21 n=21 NN cord-005453-4057qib7 10794 3 , , , cord-005453-4057qib7 10794 4 Bu Bu NNP cord-005453-4057qib7 10794 5 / / SYM cord-005453-4057qib7 10794 6 Cy Cy NNP cord-005453-4057qib7 10795 1 n=1 n=1 UH cord-005453-4057qib7 10795 2 , , , cord-005453-4057qib7 10795 3 Etop Etop NNP cord-005453-4057qib7 10795 4 / / SYM cord-005453-4057qib7 10795 5 TBI TBI NNP cord-005453-4057qib7 10795 6 n=1 n=1 NN cord-005453-4057qib7 10795 7 , , , cord-005453-4057qib7 10795 8 FluBuCy FluBuCy NNPS cord-005453-4057qib7 10795 9 n=1 n=1 CC cord-005453-4057qib7 10795 10 , , . cord-005453-4057qib7 10796 1 BEAMCam beamcam RB cord-005453-4057qib7 10796 2 n=7 n=7 NNS cord-005453-4057qib7 10796 3 , , , cord-005453-4057qib7 10796 4 FMC FMC NNP cord-005453-4057qib7 10796 5 / / SYM cord-005453-4057qib7 10796 6 T T NNP cord-005453-4057qib7 10796 7 , , , cord-005453-4057qib7 10796 8 n= n= NNP cord-005453-4057qib7 10796 9 19 19 CD cord-005453-4057qib7 10796 10 . . . cord-005453-4057qib7 10797 1 All all DT cord-005453-4057qib7 10797 2 patients patient NNS cord-005453-4057qib7 10797 3 engrafted engraft VBN cord-005453-4057qib7 10797 4 with with IN cord-005453-4057qib7 10797 5 Neutrophil Neutrophil NNP cord-005453-4057qib7 10797 6 > > XX cord-005453-4057qib7 10797 7 1.0 1.0 CD cord-005453-4057qib7 10797 8 10 10 CD cord-005453-4057qib7 10797 9 9 9 CD cord-005453-4057qib7 10797 10 /L /L . cord-005453-4057qib7 10797 11 at at IN cord-005453-4057qib7 10797 12 median median JJ cord-005453-4057qib7 10797 13 15 15 CD cord-005453-4057qib7 10797 14 days day NNS cord-005453-4057qib7 10797 15 and and CC cord-005453-4057qib7 10797 16 platelets platelet NNS cord-005453-4057qib7 10797 17 > > NFP cord-005453-4057qib7 10797 18 20 20 CD cord-005453-4057qib7 10797 19 10 10 CD cord-005453-4057qib7 10797 20 9 9 CD cord-005453-4057qib7 10797 21 /L /L . cord-005453-4057qib7 10797 22 at at IN cord-005453-4057qib7 10797 23 median median JJ cord-005453-4057qib7 10797 24 17days 17days CD cord-005453-4057qib7 10797 25 . . . cord-005453-4057qib7 10798 1 The the DT cord-005453-4057qib7 10798 2 day day NN cord-005453-4057qib7 10798 3 100 100 CD cord-005453-4057qib7 10798 4 mortality mortality NN cord-005453-4057qib7 10798 5 was be VBD cord-005453-4057qib7 10798 6 8 8 CD cord-005453-4057qib7 10798 7 % % NN cord-005453-4057qib7 10798 8 ( ( -LRB- cord-005453-4057qib7 10798 9 progressive progressive JJ cord-005453-4057qib7 10798 10 disease disease NN cord-005453-4057qib7 10798 11 4 4 CD cord-005453-4057qib7 10798 12 % % NN cord-005453-4057qib7 10798 13 , , , cord-005453-4057qib7 10798 14 NRM NRM NNP cord-005453-4057qib7 10798 15 4 4 CD cord-005453-4057qib7 10798 16 % % NN cord-005453-4057qib7 10798 17 ) ) -RRB- cord-005453-4057qib7 10798 18 with with IN cord-005453-4057qib7 10798 19 a a DT cord-005453-4057qib7 10798 20 5 5 CD cord-005453-4057qib7 10798 21 year year NN cord-005453-4057qib7 10798 22 OS os NN cord-005453-4057qib7 10798 23 of of IN cord-005453-4057qib7 10798 24 56 56 CD cord-005453-4057qib7 10798 25 % % NN cord-005453-4057qib7 10798 26 and and CC cord-005453-4057qib7 10798 27 mortality mortality NN cord-005453-4057qib7 10798 28 due due IN cord-005453-4057qib7 10798 29 to to IN cord-005453-4057qib7 10798 30 progressive progressive JJ cord-005453-4057qib7 10798 31 disease disease NN cord-005453-4057qib7 10798 32 22 22 CD cord-005453-4057qib7 10798 33 % % NN cord-005453-4057qib7 10798 34 and and CC cord-005453-4057qib7 10798 35 NRM NRM NNP cord-005453-4057qib7 10798 36 16 16 CD cord-005453-4057qib7 10798 37 % % NN cord-005453-4057qib7 10798 38 . . . cord-005453-4057qib7 10799 1 Disease Disease NNP cord-005453-4057qib7 10799 2 subtype subtype NN cord-005453-4057qib7 10799 3 influenced influence VBD cord-005453-4057qib7 10799 4 outcome outcome NN cord-005453-4057qib7 10799 5 with with IN cord-005453-4057qib7 10799 6 an an DT cord-005453-4057qib7 10799 7 OS os NN cord-005453-4057qib7 10799 8 for for IN cord-005453-4057qib7 10799 9 primary primary JJ cord-005453-4057qib7 10799 10 refractory refractory JJ cord-005453-4057qib7 10799 11 HGBL HGBL NNP cord-005453-4057qib7 10799 12 , , , cord-005453-4057qib7 10799 13 relapsed relapse VBN cord-005453-4057qib7 10799 14 HGBL HGBL NNP cord-005453-4057qib7 10799 15 , , , cord-005453-4057qib7 10799 16 tFL tFL NNP cord-005453-4057qib7 10799 17 and and CC cord-005453-4057qib7 10799 18 DHL DHL NNP cord-005453-4057qib7 10799 19 respectively respectively RB cord-005453-4057qib7 10799 20 of of IN cord-005453-4057qib7 10799 21 53 53 CD cord-005453-4057qib7 10799 22 % % NN cord-005453-4057qib7 10799 23 , , , cord-005453-4057qib7 10799 24 58 58 CD cord-005453-4057qib7 10799 25 % % NN cord-005453-4057qib7 10799 26 , , , cord-005453-4057qib7 10799 27 57 57 CD cord-005453-4057qib7 10799 28 % % NN cord-005453-4057qib7 10799 29 and and CC cord-005453-4057qib7 10799 30 89 89 CD cord-005453-4057qib7 10799 31 % % NN cord-005453-4057qib7 10799 32 . . . cord-005453-4057qib7 10800 1 23 23 CD cord-005453-4057qib7 10800 2 patients patient NNS cord-005453-4057qib7 10800 3 were be VBD cord-005453-4057qib7 10800 4 eligible eligible JJ cord-005453-4057qib7 10800 5 for for IN cord-005453-4057qib7 10800 6 a a DT cord-005453-4057qib7 10800 7 licensed licensed JJ cord-005453-4057qib7 10800 8 CAR car NN cord-005453-4057qib7 10800 9 - - HYPH cord-005453-4057qib7 10800 10 T t NN cord-005453-4057qib7 10800 11 product product NN cord-005453-4057qib7 10800 12 . . . cord-005453-4057qib7 10801 1 Conclusions conclusion NNS cord-005453-4057qib7 10801 2 : : : cord-005453-4057qib7 10802 1 The the DT cord-005453-4057qib7 10802 2 outcome outcome NN cord-005453-4057qib7 10802 3 of of IN cord-005453-4057qib7 10802 4 these these DT cord-005453-4057qib7 10802 5 high high JJ cord-005453-4057qib7 10802 6 risk risk NN cord-005453-4057qib7 10802 7 HGBL HGBL NNP cord-005453-4057qib7 10802 8 patients patient NNS cord-005453-4057qib7 10802 9 have have VBP cord-005453-4057qib7 10802 10 an an DT cord-005453-4057qib7 10802 11 acceptable acceptable JJ cord-005453-4057qib7 10802 12 OS os NN cord-005453-4057qib7 10802 13 of of IN cord-005453-4057qib7 10802 14 56 56 CD cord-005453-4057qib7 10802 15 % % NN cord-005453-4057qib7 10802 16 , , , cord-005453-4057qib7 10802 17 with with IN cord-005453-4057qib7 10802 18 relapsed relapse VBN cord-005453-4057qib7 10802 19 disease disease NN cord-005453-4057qib7 10802 20 being be VBG cord-005453-4057qib7 10802 21 the the DT cord-005453-4057qib7 10802 22 commonest common JJS cord-005453-4057qib7 10802 23 cause cause NN cord-005453-4057qib7 10802 24 of of IN cord-005453-4057qib7 10802 25 mortality mortality NN cord-005453-4057qib7 10802 26 . . . cord-005453-4057qib7 10803 1 Patients patient NNS cord-005453-4057qib7 10803 2 with with IN cord-005453-4057qib7 10803 3 DHL DHL NNP cord-005453-4057qib7 10803 4 have have VBP cord-005453-4057qib7 10803 5 a a DT cord-005453-4057qib7 10803 6 particularly particularly RB cord-005453-4057qib7 10803 7 good good JJ cord-005453-4057qib7 10803 8 outcome outcome NN cord-005453-4057qib7 10803 9 in in IN cord-005453-4057qib7 10803 10 this this DT cord-005453-4057qib7 10803 11 series series NN cord-005453-4057qib7 10803 12 ; ; , cord-005453-4057qib7 10803 13 recent recent JJ cord-005453-4057qib7 10803 14 evidence evidence NN cord-005453-4057qib7 10803 15 indicates indicate VBZ cord-005453-4057qib7 10803 16 that that IN cord-005453-4057qib7 10803 17 some some DT cord-005453-4057qib7 10803 18 of of IN cord-005453-4057qib7 10803 19 these these DT cord-005453-4057qib7 10803 20 patients patient NNS cord-005453-4057qib7 10803 21 with with IN cord-005453-4057qib7 10803 22 a a DT cord-005453-4057qib7 10803 23 non non JJ cord-005453-4057qib7 10803 24 - - JJ cord-005453-4057qib7 10803 25 immunoglobulin immunoglobulin JJ cord-005453-4057qib7 10803 26 gene gene NN cord-005453-4057qib7 10803 27 associated associate VBD cord-005453-4057qib7 10803 28 MYC MYC NNP cord-005453-4057qib7 10803 29 translocation translocation NN cord-005453-4057qib7 10803 30 could could MD cord-005453-4057qib7 10803 31 be be VB cord-005453-4057qib7 10803 32 managed manage VBN cord-005453-4057qib7 10803 33 more more RBR cord-005453-4057qib7 10803 34 conservatively conservatively RB cord-005453-4057qib7 10803 35 ( ( -LRB- cord-005453-4057qib7 10803 36 ASH ASH NNP cord-005453-4057qib7 10803 37 Sehn Sehn NNP cord-005453-4057qib7 10803 38 ) ) -RRB- cord-005453-4057qib7 10803 39 . . . cord-005453-4057qib7 10804 1 The the DT cord-005453-4057qib7 10804 2 outcomes outcome NNS cord-005453-4057qib7 10804 3 achieved achieve VBN cord-005453-4057qib7 10804 4 with with IN cord-005453-4057qib7 10804 5 allogeneic allogeneic NN cord-005453-4057qib7 10804 6 - - HYPH cord-005453-4057qib7 10804 7 SCT sct NN cord-005453-4057qib7 10804 8 in in IN cord-005453-4057qib7 10804 9 this this DT cord-005453-4057qib7 10804 10 series series NN cord-005453-4057qib7 10804 11 will will MD cord-005453-4057qib7 10804 12 provide provide VB cord-005453-4057qib7 10804 13 a a DT cord-005453-4057qib7 10804 14 baseline baseline NN cord-005453-4057qib7 10804 15 for for IN cord-005453-4057qib7 10804 16 outcome outcome NN cord-005453-4057qib7 10804 17 assessment assessment NN cord-005453-4057qib7 10804 18 with with IN cord-005453-4057qib7 10804 19 a a DT cord-005453-4057qib7 10804 20 CART cart NN cord-005453-4057qib7 10804 21 program program NN cord-005453-4057qib7 10804 22 . . . cord-005453-4057qib7 10805 1 Disclosure disclosure NN cord-005453-4057qib7 10805 2 : : : cord-005453-4057qib7 10806 1 Nothing nothing NN cord-005453-4057qib7 10806 2 to to TO cord-005453-4057qib7 10806 3 Declare declare VB cord-005453-4057qib7 10806 4 Background background NN cord-005453-4057qib7 10806 5 : : : cord-005453-4057qib7 10806 6 Immune immune JJ cord-005453-4057qib7 10806 7 checkpoint checkpoint NN cord-005453-4057qib7 10806 8 inhibitors inhibitor NNS cord-005453-4057qib7 10806 9 ( ( -LRB- cord-005453-4057qib7 10806 10 ICI ICI NNP cord-005453-4057qib7 10806 11 ) ) -RRB- cord-005453-4057qib7 10806 12 allow allow VB cord-005453-4057qib7 10806 13 to to TO cord-005453-4057qib7 10806 14 achieve achieve VB cord-005453-4057qib7 10806 15 a a DT cord-005453-4057qib7 10806 16 durable durable JJ cord-005453-4057qib7 10806 17 remission remission NN cord-005453-4057qib7 10806 18 in in IN cord-005453-4057qib7 10806 19 patients patient NNS cord-005453-4057qib7 10806 20 with with IN cord-005453-4057qib7 10806 21 resistant resistant JJ cord-005453-4057qib7 10806 22 or or CC cord-005453-4057qib7 10806 23 refractory refractory JJ cord-005453-4057qib7 10806 24 ( ( -LRB- cord-005453-4057qib7 10806 25 r r NN cord-005453-4057qib7 10806 26 / / SYM cord-005453-4057qib7 10806 27 r r NN cord-005453-4057qib7 10806 28 ) ) -RRB- cord-005453-4057qib7 10806 29 classical classical JJ cord-005453-4057qib7 10806 30 Hodgkin Hodgkin NNP cord-005453-4057qib7 10806 31 lymphoma lymphoma NN cord-005453-4057qib7 10806 32 . . . cord-005453-4057qib7 10807 1 However however RB cord-005453-4057qib7 10807 2 , , , cord-005453-4057qib7 10807 3 the the DT cord-005453-4057qib7 10807 4 information information NN cord-005453-4057qib7 10807 5 about about IN cord-005453-4057qib7 10807 6 optimal optimal JJ cord-005453-4057qib7 10807 7 duration duration NN cord-005453-4057qib7 10807 8 of of IN cord-005453-4057qib7 10807 9 therapy therapy NN cord-005453-4057qib7 10807 10 and and CC cord-005453-4057qib7 10807 11 the the DT cord-005453-4057qib7 10807 12 prognosis prognosis NN cord-005453-4057qib7 10807 13 of of IN cord-005453-4057qib7 10807 14 the the DT cord-005453-4057qib7 10807 15 patients patient NNS cord-005453-4057qib7 10807 16 after after IN cord-005453-4057qib7 10807 17 ICI ICI NNP cord-005453-4057qib7 10807 18 cessation cessation NN cord-005453-4057qib7 10807 19 is be VBZ cord-005453-4057qib7 10807 20 limited limit VBN cord-005453-4057qib7 10807 21 ( ( -LRB- cord-005453-4057qib7 10807 22 Manson Manson NNP cord-005453-4057qib7 10807 23 , , , cord-005453-4057qib7 10807 24 Blood blood NN cord-005453-4057qib7 10807 25 2018 2018 CD cord-005453-4057qib7 10807 26 ) ) -RRB- cord-005453-4057qib7 10807 27 . . . cord-005453-4057qib7 10808 1 Therefore therefore RB cord-005453-4057qib7 10808 2 , , , cord-005453-4057qib7 10808 3 the the DT cord-005453-4057qib7 10808 4 optimal optimal JJ cord-005453-4057qib7 10808 5 role role NN cord-005453-4057qib7 10808 6 of of IN cord-005453-4057qib7 10808 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 10808 8 SCT SCT NNP cord-005453-4057qib7 10808 9 ( ( -LRB- cord-005453-4057qib7 10808 10 HSCT HSCT NNP cord-005453-4057qib7 10808 11 ) ) -RRB- cord-005453-4057qib7 10808 12 in in IN cord-005453-4057qib7 10808 13 this this DT cord-005453-4057qib7 10808 14 patient patient NN cord-005453-4057qib7 10808 15 group group NN cord-005453-4057qib7 10808 16 is be VBZ cord-005453-4057qib7 10808 17 not not RB cord-005453-4057qib7 10808 18 defined define VBN cord-005453-4057qib7 10808 19 . . . cord-005453-4057qib7 10809 1 Our -PRON- PRP$ cord-005453-4057qib7 10809 2 aim aim NN cord-005453-4057qib7 10809 3 was be VBD cord-005453-4057qib7 10809 4 to to TO cord-005453-4057qib7 10809 5 determine determine VB cord-005453-4057qib7 10809 6 remission remission NN cord-005453-4057qib7 10809 7 duration duration NN cord-005453-4057qib7 10809 8 in in IN cord-005453-4057qib7 10809 9 patients patient NNS cord-005453-4057qib7 10809 10 who who WP cord-005453-4057qib7 10809 11 discontinued discontinue VBD cord-005453-4057qib7 10809 12 ICI ICI NNP cord-005453-4057qib7 10810 1 monotherapy monotherapy IN cord-005453-4057qib7 10810 2 after after IN cord-005453-4057qib7 10810 3 achieving achieve VBG cord-005453-4057qib7 10810 4 complete complete JJ cord-005453-4057qib7 10810 5 remission remission NN cord-005453-4057qib7 10810 6 ( ( -LRB- cord-005453-4057qib7 10810 7 CR CR NNP cord-005453-4057qib7 10810 8 ) ) -RRB- cord-005453-4057qib7 10810 9 . . . cord-005453-4057qib7 10811 1 Methods method NNS cord-005453-4057qib7 10811 2 : : : cord-005453-4057qib7 10812 1 This this DT cord-005453-4057qib7 10812 2 analysis analysis NN cord-005453-4057qib7 10812 3 included include VBD cord-005453-4057qib7 10812 4 20 20 CD cord-005453-4057qib7 10812 5 patients patient NNS cord-005453-4057qib7 10812 6 ( ( -LRB- cord-005453-4057qib7 10812 7 5 5 CD cord-005453-4057qib7 10812 8 male/15 male/15 NNP cord-005453-4057qib7 10812 9 female female NN cord-005453-4057qib7 10812 10 ) ) -RRB- cord-005453-4057qib7 10812 11 aged age VBN cord-005453-4057qib7 10812 12 19 19 CD cord-005453-4057qib7 10812 13 to to IN cord-005453-4057qib7 10812 14 47 47 CD cord-005453-4057qib7 10813 1 ( ( -LRB- cord-005453-4057qib7 10813 2 median median NN cord-005453-4057qib7 10813 3 32 32 CD cord-005453-4057qib7 10813 4 years year NNS cord-005453-4057qib7 10813 5 ) ) -RRB- cord-005453-4057qib7 10813 6 with with IN cord-005453-4057qib7 10813 7 r r NNP cord-005453-4057qib7 10813 8 / / SYM cord-005453-4057qib7 10813 9 r r NN cord-005453-4057qib7 10813 10 classical classical JJ cord-005453-4057qib7 10813 11 Hodgkin Hodgkin NNP cord-005453-4057qib7 10813 12 lymphoma lymphoma NN cord-005453-4057qib7 10813 13 who who WP cord-005453-4057qib7 10813 14 were be VBD cord-005453-4057qib7 10813 15 treated treat VBN cord-005453-4057qib7 10813 16 with with IN cord-005453-4057qib7 10813 17 nivolumab nivolumab NNP cord-005453-4057qib7 10813 18 ( ( -LRB- cord-005453-4057qib7 10813 19 3 3 CD cord-005453-4057qib7 10813 20 mg mg NNP cord-005453-4057qib7 10813 21 / / SYM cord-005453-4057qib7 10813 22 kg kg NN cord-005453-4057qib7 10813 23 every every DT cord-005453-4057qib7 10813 24 14 14 CD cord-005453-4057qib7 10813 25 days day NNS cord-005453-4057qib7 10813 26 ) ) -RRB- cord-005453-4057qib7 10813 27 and and CC cord-005453-4057qib7 10813 28 achieved achieve VBD cord-005453-4057qib7 10813 29 CR CR NNP cord-005453-4057qib7 10813 30 . . . cord-005453-4057qib7 10814 1 Response response NN cord-005453-4057qib7 10814 2 was be VBD cord-005453-4057qib7 10814 3 assessed assess VBN cord-005453-4057qib7 10814 4 by by IN cord-005453-4057qib7 10815 1 positron positron NN cord-005453-4057qib7 10815 2 - - HYPH cord-005453-4057qib7 10815 3 emission emission NN cord-005453-4057qib7 10815 4 tomography tomography NN cord-005453-4057qib7 10815 5 / / SYM cord-005453-4057qib7 10815 6 computed compute VBN cord-005453-4057qib7 10815 7 tomography tomography NN cord-005453-4057qib7 10815 8 ( ( -LRB- cord-005453-4057qib7 10815 9 PET PET NNP cord-005453-4057qib7 10815 10 / / SYM cord-005453-4057qib7 10815 11 CT CT NNP cord-005453-4057qib7 10815 12 ) ) -RRB- cord-005453-4057qib7 10815 13 using use VBG cord-005453-4057qib7 10815 14 LYRIC LYRIC NNP cord-005453-4057qib7 10815 15 criteria criterion NNS cord-005453-4057qib7 10815 16 every every DT cord-005453-4057qib7 10815 17 3 3 CD cord-005453-4057qib7 10815 18 month month NN cord-005453-4057qib7 10815 19 . . . cord-005453-4057qib7 10816 1 After after IN cord-005453-4057qib7 10816 2 nivolumab nivolumab NNP cord-005453-4057qib7 10816 3 therapy therapy NN cord-005453-4057qib7 10816 4 had have VBD cord-005453-4057qib7 10816 5 been be VBN cord-005453-4057qib7 10816 6 stopped stop VBN cord-005453-4057qib7 10816 7 the the DT cord-005453-4057qib7 10816 8 patients patient NNS cord-005453-4057qib7 10816 9 received receive VBN cord-005453-4057qib7 10817 1 no no DT cord-005453-4057qib7 10817 2 other other JJ cord-005453-4057qib7 10817 3 treatment treatment NN cord-005453-4057qib7 10817 4 and and CC cord-005453-4057qib7 10817 5 disease disease NN cord-005453-4057qib7 10817 6 was be VBD cord-005453-4057qib7 10817 7 assessed assess VBN cord-005453-4057qib7 10817 8 every every DT cord-005453-4057qib7 10817 9 3 3 CD cord-005453-4057qib7 10817 10 months month NNS cord-005453-4057qib7 10817 11 by by IN cord-005453-4057qib7 10817 12 PET PET NNP cord-005453-4057qib7 10817 13 / / SYM cord-005453-4057qib7 10817 14 CT CT NNP cord-005453-4057qib7 10817 15 . . . cord-005453-4057qib7 10818 1 Median median JJ cord-005453-4057qib7 10818 2 follow follow NN cord-005453-4057qib7 10818 3 - - HYPH cord-005453-4057qib7 10818 4 up up NN cord-005453-4057qib7 10818 5 after after IN cord-005453-4057qib7 10818 6 therapy therapy NN cord-005453-4057qib7 10818 7 discontinuation discontinuation NN cord-005453-4057qib7 10818 8 was be VBD cord-005453-4057qib7 10818 9 20 20 CD cord-005453-4057qib7 10818 10 ( ( -LRB- cord-005453-4057qib7 10818 11 10 10 CD cord-005453-4057qib7 10818 12 - - SYM cord-005453-4057qib7 10818 13 21 21 CD cord-005453-4057qib7 10818 14 ) ) -RRB- cord-005453-4057qib7 10818 15 months month NNS cord-005453-4057qib7 10818 16 . . . cord-005453-4057qib7 10819 1 Results result NNS cord-005453-4057qib7 10819 2 : : : cord-005453-4057qib7 10820 1 At at IN cord-005453-4057qib7 10820 2 the the DT cord-005453-4057qib7 10820 3 moment moment NN cord-005453-4057qib7 10820 4 of of IN cord-005453-4057qib7 10820 5 therapy therapy NN cord-005453-4057qib7 10820 6 initiation initiation NN cord-005453-4057qib7 10820 7 14 14 CD cord-005453-4057qib7 10820 8 ( ( -LRB- cord-005453-4057qib7 10820 9 70 70 CD cord-005453-4057qib7 10820 10 % % NN cord-005453-4057qib7 10820 11 ) ) -RRB- cord-005453-4057qib7 10820 12 patients patient NNS cord-005453-4057qib7 10820 13 had have VBD cord-005453-4057qib7 10820 14 stage stage NN cord-005453-4057qib7 10820 15 4 4 CD cord-005453-4057qib7 10820 16 disease disease NN cord-005453-4057qib7 10820 17 , , , cord-005453-4057qib7 10820 18 11 11 CD cord-005453-4057qib7 10820 19 ( ( -LRB- cord-005453-4057qib7 10820 20 55 55 CD cord-005453-4057qib7 10820 21 % % NN cord-005453-4057qib7 10820 22 ) ) -RRB- cord-005453-4057qib7 10821 1 patients patient NNS cord-005453-4057qib7 10821 2 had have VBD cord-005453-4057qib7 10821 3 progressive progressive JJ cord-005453-4057qib7 10821 4 disease disease NN cord-005453-4057qib7 10821 5 ( ( -LRB- cord-005453-4057qib7 10821 6 PD PD NNP cord-005453-4057qib7 10821 7 ) ) -RRB- cord-005453-4057qib7 10821 8 , , , cord-005453-4057qib7 10821 9 4 4 CD cord-005453-4057qib7 10821 10 ( ( -LRB- cord-005453-4057qib7 10821 11 20 20 CD cord-005453-4057qib7 10821 12 % % NN cord-005453-4057qib7 10821 13 ) ) -RRB- cord-005453-4057qib7 10821 14 patients patient NNS cord-005453-4057qib7 10821 15 had have VBD cord-005453-4057qib7 10821 16 stable stable JJ cord-005453-4057qib7 10821 17 disease disease NN cord-005453-4057qib7 10821 18 , , , cord-005453-4057qib7 10821 19 3 3 CD cord-005453-4057qib7 10821 20 ( ( -LRB- cord-005453-4057qib7 10821 21 15 15 CD cord-005453-4057qib7 10821 22 % % NN cord-005453-4057qib7 10821 23 ) ) -RRB- cord-005453-4057qib7 10822 1 patients patient NNS cord-005453-4057qib7 10822 2 had have VBD cord-005453-4057qib7 10822 3 partial partial JJ cord-005453-4057qib7 10822 4 remission remission NN cord-005453-4057qib7 10822 5 and and CC cord-005453-4057qib7 10822 6 2 2 CD cord-005453-4057qib7 10822 7 ( ( -LRB- cord-005453-4057qib7 10822 8 10%)complete 10%)complete JJ cord-005453-4057qib7 10822 9 remission remission NN cord-005453-4057qib7 10822 10 ; ; : cord-005453-4057qib7 10822 11 12 12 CD cord-005453-4057qib7 10822 12 ( ( -LRB- cord-005453-4057qib7 10822 13 60 60 CD cord-005453-4057qib7 10822 14 % % NN cord-005453-4057qib7 10822 15 ) ) -RRB- cord-005453-4057qib7 10823 1 patients patient NNS cord-005453-4057qib7 10823 2 had have VBD cord-005453-4057qib7 10823 3 B b NN cord-005453-4057qib7 10823 4 - - HYPH cord-005453-4057qib7 10823 5 symptoms symptom NNS cord-005453-4057qib7 10823 6 and and CC cord-005453-4057qib7 10823 7 ECOG ECOG NNP cord-005453-4057qib7 10823 8 score score NN cord-005453-4057qib7 10824 1 > > XX cord-005453-4057qib7 10824 2 1 1 CD cord-005453-4057qib7 10824 3 . . . cord-005453-4057qib7 10825 1 The the DT cord-005453-4057qib7 10825 2 median median JJ cord-005453-4057qib7 10825 3 number number NN cord-005453-4057qib7 10825 4 of of IN cord-005453-4057qib7 10825 5 previous previous JJ cord-005453-4057qib7 10825 6 therapy therapy NN cord-005453-4057qib7 10825 7 lines line NNS cord-005453-4057qib7 10825 8 was be VBD cord-005453-4057qib7 10825 9 5 5 CD cord-005453-4057qib7 10825 10 ( ( -LRB- cord-005453-4057qib7 10825 11 3 3 CD cord-005453-4057qib7 10825 12 ) ) -RRB- cord-005453-4057qib7 10825 13 ( ( -LRB- cord-005453-4057qib7 10825 14 4 4 LS cord-005453-4057qib7 10825 15 ) ) -RRB- cord-005453-4057qib7 10825 16 ( ( -LRB- cord-005453-4057qib7 10825 17 5 5 LS cord-005453-4057qib7 10825 18 ) ) -RRB- cord-005453-4057qib7 10825 19 ( ( -LRB- cord-005453-4057qib7 10825 20 6 6 LS cord-005453-4057qib7 10825 21 ) ) -RRB- cord-005453-4057qib7 10825 22 ( ( -LRB- cord-005453-4057qib7 10825 23 7 7 LS cord-005453-4057qib7 10825 24 ) ) -RRB- cord-005453-4057qib7 10825 25 ( ( -LRB- cord-005453-4057qib7 10825 26 8) 8) NNP cord-005453-4057qib7 10825 27 ( ( -LRB- cord-005453-4057qib7 10825 28 9 9 CD cord-005453-4057qib7 10825 29 ) ) -RRB- cord-005453-4057qib7 10825 30 ( ( -LRB- cord-005453-4057qib7 10825 31 10 10 CD cord-005453-4057qib7 10825 32 ) ) -RRB- cord-005453-4057qib7 10825 33 . . . cord-005453-4057qib7 10826 1 Before before IN cord-005453-4057qib7 10826 2 nivolumab nivolumab NNP cord-005453-4057qib7 10826 3 initiation initiation NN cord-005453-4057qib7 10826 4 high high RB cord-005453-4057qib7 10826 5 dose dose NN cord-005453-4057qib7 10826 6 chemotherapy chemotherapy NN cord-005453-4057qib7 10826 7 with with IN cord-005453-4057qib7 10826 8 autologous autologous JJ cord-005453-4057qib7 10826 9 SCT SCT NNP cord-005453-4057qib7 10826 10 was be VBD cord-005453-4057qib7 10826 11 performed perform VBN cord-005453-4057qib7 10826 12 in in IN cord-005453-4057qib7 10826 13 9 9 CD cord-005453-4057qib7 10826 14 patients patient NNS cord-005453-4057qib7 10826 15 ( ( -LRB- cord-005453-4057qib7 10826 16 45 45 CD cord-005453-4057qib7 10826 17 % % NN cord-005453-4057qib7 10826 18 ) ) -RRB- cord-005453-4057qib7 10826 19 and and CC cord-005453-4057qib7 10826 20 8 8 CD cord-005453-4057qib7 10826 21 ( ( -LRB- cord-005453-4057qib7 10826 22 40 40 CD cord-005453-4057qib7 10826 23 % % NN cord-005453-4057qib7 10826 24 ) ) -RRB- cord-005453-4057qib7 10826 25 received receive VBD cord-005453-4057qib7 10826 26 brentuximab brentuximab NNP cord-005453-4057qib7 10826 27 vedotin vedotin NNP cord-005453-4057qib7 10826 28 . . . cord-005453-4057qib7 10827 1 The the DT cord-005453-4057qib7 10827 2 median median JJ cord-005453-4057qib7 10827 3 number number NN cord-005453-4057qib7 10827 4 of of IN cord-005453-4057qib7 10827 5 nivolumab nivolumab JJ cord-005453-4057qib7 10827 6 cycles cycle NNS cord-005453-4057qib7 10827 7 was be VBD cord-005453-4057qib7 10827 8 25 25 CD cord-005453-4057qib7 10827 9 ( ( -LRB- cord-005453-4057qib7 10827 10 18 18 CD cord-005453-4057qib7 10827 11 - - SYM cord-005453-4057qib7 10827 12 30 30 CD cord-005453-4057qib7 10827 13 ) ) -RRB- cord-005453-4057qib7 10827 14 . . . cord-005453-4057qib7 10828 1 CR CR NNP cord-005453-4057qib7 10828 2 was be VBD cord-005453-4057qib7 10828 3 achieved achieve VBN cord-005453-4057qib7 10828 4 after after IN cord-005453-4057qib7 10828 5 median median NN cord-005453-4057qib7 10828 6 of of IN cord-005453-4057qib7 10828 7 6 6 CD cord-005453-4057qib7 10828 8 ( ( -LRB- cord-005453-4057qib7 10828 9 6 6 CD cord-005453-4057qib7 10828 10 - - SYM cord-005453-4057qib7 10828 11 18 18 CD cord-005453-4057qib7 10828 12 ) ) -RRB- cord-005453-4057qib7 10828 13 cycles cycle NNS cord-005453-4057qib7 10828 14 . . . cord-005453-4057qib7 10829 1 The the DT cord-005453-4057qib7 10829 2 median median JJ cord-005453-4057qib7 10829 3 duration duration NN cord-005453-4057qib7 10829 4 of of IN cord-005453-4057qib7 10829 5 therapy therapy NN cord-005453-4057qib7 10829 6 after after IN cord-005453-4057qib7 10829 7 achievement achievement NN cord-005453-4057qib7 10829 8 of of IN cord-005453-4057qib7 10829 9 CR CR NNP cord-005453-4057qib7 10829 10 was be VBD cord-005453-4057qib7 10829 11 7 7 CD cord-005453-4057qib7 10829 12 ( ( -LRB- cord-005453-4057qib7 10829 13 1 1 CD cord-005453-4057qib7 10829 14 - - SYM cord-005453-4057qib7 10829 15 15 15 CD cord-005453-4057qib7 10829 16 ) ) -RRB- cord-005453-4057qib7 10829 17 months month NNS cord-005453-4057qib7 10829 18 . . . cord-005453-4057qib7 10830 1 At at IN cord-005453-4057qib7 10830 2 the the DT cord-005453-4057qib7 10830 3 time time NN cord-005453-4057qib7 10830 4 of of IN cord-005453-4057qib7 10830 5 analysis analysis NN cord-005453-4057qib7 10830 6 , , , cord-005453-4057qib7 10830 7 all all DT cord-005453-4057qib7 10830 8 patients patient NNS cord-005453-4057qib7 10830 9 were be VBD cord-005453-4057qib7 10830 10 alive alive JJ cord-005453-4057qib7 10830 11 , , , cord-005453-4057qib7 10830 12 8 8 CD cord-005453-4057qib7 10830 13 ( ( -LRB- cord-005453-4057qib7 10830 14 40 40 CD cord-005453-4057qib7 10830 15 % % NN cord-005453-4057qib7 10830 16 ) ) -RRB- cord-005453-4057qib7 10831 1 out out IN cord-005453-4057qib7 10831 2 of of IN cord-005453-4057qib7 10831 3 20 20 CD cord-005453-4057qib7 10831 4 patients patient NNS cord-005453-4057qib7 10831 5 relapsed relapse VBN cord-005453-4057qib7 10831 6 after after IN cord-005453-4057qib7 10831 7 therapy therapy NN cord-005453-4057qib7 10831 8 discontinuation discontinuation NN cord-005453-4057qib7 10831 9 . . . cord-005453-4057qib7 10832 1 The the DT cord-005453-4057qib7 10832 2 median median JJ cord-005453-4057qib7 10832 3 progression progression NN cord-005453-4057qib7 10832 4 - - HYPH cord-005453-4057qib7 10832 5 free free JJ cord-005453-4057qib7 10832 6 survival survival NN cord-005453-4057qib7 10832 7 ( ( -LRB- cord-005453-4057qib7 10832 8 PFS PFS NNP cord-005453-4057qib7 10832 9 ) ) -RRB- cord-005453-4057qib7 10832 10 for for IN cord-005453-4057qib7 10832 11 the the DT cord-005453-4057qib7 10832 12 total total JJ cord-005453-4057qib7 10832 13 group group NN cord-005453-4057qib7 10832 14 was be VBD cord-005453-4057qib7 10832 15 not not RB cord-005453-4057qib7 10832 16 achieved achieve VBN cord-005453-4057qib7 10832 17 . . . cord-005453-4057qib7 10833 1 Among among IN cord-005453-4057qib7 10833 2 patients patient NNS cord-005453-4057qib7 10833 3 with with IN cord-005453-4057qib7 10833 4 relapse relapse NN cord-005453-4057qib7 10833 5 , , , cord-005453-4057qib7 10833 6 the the DT cord-005453-4057qib7 10833 7 median median JJ cord-005453-4057qib7 10833 8 time time NN cord-005453-4057qib7 10833 9 before before IN cord-005453-4057qib7 10833 10 PD PD NNP cord-005453-4057qib7 10833 11 was be VBD cord-005453-4057qib7 10833 12 11 11 CD cord-005453-4057qib7 10833 13 ( ( -LRB- cord-005453-4057qib7 10833 14 5 5 CD cord-005453-4057qib7 10833 15 - - SYM cord-005453-4057qib7 10833 16 20 20 CD cord-005453-4057qib7 10833 17 ) ) -RRB- cord-005453-4057qib7 10833 18 months month NNS cord-005453-4057qib7 10833 19 . . . cord-005453-4057qib7 10834 1 After after IN cord-005453-4057qib7 10834 2 relapse relapse NN cord-005453-4057qib7 10834 3 all all DT cord-005453-4057qib7 10834 4 patients patient NNS cord-005453-4057qib7 10834 5 were be VBD cord-005453-4057qib7 10834 6 retreated retreat VBN cord-005453-4057qib7 10834 7 with with IN cord-005453-4057qib7 10834 8 nivolumab nivolumab NNP cord-005453-4057qib7 10834 9 monotherapy monotherapy NN cord-005453-4057qib7 10834 10 or or CC cord-005453-4057qib7 10834 11 with with IN cord-005453-4057qib7 10834 12 chemotherapy chemotherapy NN cord-005453-4057qib7 10834 13 combination combination NN cord-005453-4057qib7 10834 14 . . . cord-005453-4057qib7 10835 1 One one CD cord-005453-4057qib7 10835 2 patient patient NN cord-005453-4057qib7 10835 3 achieved achieve VBD cord-005453-4057qib7 10835 4 complete complete JJ cord-005453-4057qib7 10835 5 remission remission NN cord-005453-4057qib7 10835 6 ; ; : cord-005453-4057qib7 10835 7 1 1 CD cord-005453-4057qib7 10835 8 -partial -partial JJ cord-005453-4057qib7 10835 9 remission remission NN cord-005453-4057qib7 10835 10 ; ; : cord-005453-4057qib7 10835 11 1 1 CD cord-005453-4057qib7 10835 12 -indeterminate -indeterminate NN cord-005453-4057qib7 10835 13 response response NN cord-005453-4057qib7 10835 14 type type NN cord-005453-4057qib7 10835 15 2 2 CD cord-005453-4057qib7 10835 16 . . . cord-005453-4057qib7 10836 1 Other other JJ cord-005453-4057qib7 10836 2 patients patient NNS cord-005453-4057qib7 10836 3 are be VBP cord-005453-4057qib7 10836 4 continuing continue VBG cord-005453-4057qib7 10836 5 the the DT cord-005453-4057qib7 10836 6 therapy therapy NN cord-005453-4057qib7 10836 7 and and CC cord-005453-4057qib7 10836 8 their -PRON- PRP$ cord-005453-4057qib7 10836 9 response response NN cord-005453-4057qib7 10836 10 has have VBZ cord-005453-4057qib7 10836 11 not not RB cord-005453-4057qib7 10836 12 yet yet RB cord-005453-4057qib7 10836 13 been be VBN cord-005453-4057qib7 10836 14 evaluated evaluate VBN cord-005453-4057qib7 10836 15 . . . cord-005453-4057qib7 10837 1 Conclusions conclusion NNS cord-005453-4057qib7 10837 2 : : : cord-005453-4057qib7 10837 3 While while IN cord-005453-4057qib7 10837 4 complete complete JJ cord-005453-4057qib7 10837 5 response response NN cord-005453-4057qib7 10837 6 was be VBD cord-005453-4057qib7 10837 7 maintained maintain VBN cord-005453-4057qib7 10837 8 in in IN cord-005453-4057qib7 10837 9 some some DT cord-005453-4057qib7 10837 10 patients patient NNS cord-005453-4057qib7 10837 11 at at IN cord-005453-4057qib7 10837 12 median median NN cord-005453-4057qib7 10837 13 follow follow VB cord-005453-4057qib7 10837 14 up up IN cord-005453-4057qib7 10837 15 of of IN cord-005453-4057qib7 10837 16 20 20 CD cord-005453-4057qib7 10837 17 months month NNS cord-005453-4057qib7 10837 18 after after IN cord-005453-4057qib7 10837 19 nivolumab nivolumab NNP cord-005453-4057qib7 10837 20 therapy therapy NNP cord-005453-4057qib7 10837 21 cessation cessation NNP cord-005453-4057qib7 10837 22 , , , cord-005453-4057qib7 10837 23 the the DT cord-005453-4057qib7 10837 24 PFS PFS NNP cord-005453-4057qib7 10837 25 plateau plateau NN cord-005453-4057qib7 10837 26 was be VBD cord-005453-4057qib7 10837 27 not not RB cord-005453-4057qib7 10837 28 reached reach VBN cord-005453-4057qib7 10837 29 . . . cord-005453-4057qib7 10838 1 We -PRON- PRP cord-005453-4057qib7 10838 2 report report VBP cord-005453-4057qib7 10838 3 that that IN cord-005453-4057qib7 10838 4 patients patient NNS cord-005453-4057qib7 10838 5 with with IN cord-005453-4057qib7 10838 6 relapse relapse NN cord-005453-4057qib7 10838 7 after after IN cord-005453-4057qib7 10838 8 nivolumab nivolumab NNP cord-005453-4057qib7 10838 9 discontinuation discontinuation NN cord-005453-4057qib7 10838 10 sustained sustain VBD cord-005453-4057qib7 10838 11 sensitivity sensitivity NN cord-005453-4057qib7 10838 12 to to IN cord-005453-4057qib7 10838 13 nivolumab nivolumab NNP cord-005453-4057qib7 10838 14 and and CC cord-005453-4057qib7 10838 15 achieved achieve VBD cord-005453-4057qib7 10838 16 a a DT cord-005453-4057qib7 10838 17 response response NN cord-005453-4057qib7 10838 18 during during IN cord-005453-4057qib7 10838 19 retreatment retreatment NN cord-005453-4057qib7 10838 20 with with IN cord-005453-4057qib7 10838 21 nivolumab nivolumab NNP cord-005453-4057qib7 10838 22 monotherapy monotherapy NN cord-005453-4057qib7 10838 23 or or CC cord-005453-4057qib7 10838 24 with with IN cord-005453-4057qib7 10838 25 chemotherapy chemotherapy NN cord-005453-4057qib7 10838 26 combination combination NN cord-005453-4057qib7 10838 27 . . . cord-005453-4057qib7 10839 1 In in IN cord-005453-4057qib7 10839 2 patients patient NNS cord-005453-4057qib7 10839 3 with with IN cord-005453-4057qib7 10839 4 unsatisfactory unsatisfactory JJ cord-005453-4057qib7 10839 5 response response NN cord-005453-4057qib7 10839 6 to to IN cord-005453-4057qib7 10839 7 nivolumab nivolumab NNP cord-005453-4057qib7 10839 8 retreatment retreatment NN cord-005453-4057qib7 10839 9 , , , cord-005453-4057qib7 10839 10 HSCT HSCT NNP cord-005453-4057qib7 10839 11 option option NN cord-005453-4057qib7 10839 12 should should MD cord-005453-4057qib7 10839 13 be be VB cord-005453-4057qib7 10839 14 considered consider VBN cord-005453-4057qib7 10839 15 . . . cord-005453-4057qib7 10840 1 Disclosure disclosure NN cord-005453-4057qib7 10840 2 : : : cord-005453-4057qib7 10840 3 Nothing nothing NN cord-005453-4057qib7 10840 4 to to TO cord-005453-4057qib7 10840 5 declare declare VB cord-005453-4057qib7 10840 6 High High NNP cord-005453-4057qib7 10840 7 dose dose NN cord-005453-4057qib7 10840 8 chemotherapy chemotherapy NN cord-005453-4057qib7 10840 9 with with IN cord-005453-4057qib7 10840 10 autologous autologous JJ cord-005453-4057qib7 10840 11 stem stem NN cord-005453-4057qib7 10840 12 cell cell NN cord-005453-4057qib7 10840 13 transplantation transplantation NN cord-005453-4057qib7 10840 14 in in IN cord-005453-4057qib7 10840 15 primary primary JJ cord-005453-4057qib7 10840 16 central central JJ cord-005453-4057qib7 10840 17 nervous nervous JJ cord-005453-4057qib7 10840 18 system system NN cord-005453-4057qib7 10840 19 lymphoma lymphoma NN cord-005453-4057qib7 10840 20 : : : cord-005453-4057qib7 10841 1 Data datum NNS cord-005453-4057qib7 10841 2 from from IN cord-005453-4057qib7 10841 3 the the DT cord-005453-4057qib7 10841 4 japan japan NNP cord-005453-4057qib7 10841 5 society society NN cord-005453-4057qib7 10841 6 for for IN cord-005453-4057qib7 10841 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 10841 8 cell cell NN cord-005453-4057qib7 10841 9 transplantation transplantation NN cord-005453-4057qib7 10841 10 ( ( -LRB- cord-005453-4057qib7 10841 11 JSHCT JSHCT NNP cord-005453-4057qib7 10841 12 ) ) -RRB- cord-005453-4057qib7 10841 13 registry registry NN cord-005453-4057qib7 10841 14 Center Center NNP cord-005453-4057qib7 10841 15 Hospital Hospital NNP cord-005453-4057qib7 10841 16 , , , cord-005453-4057qib7 10841 17 Tokyo Tokyo NNP cord-005453-4057qib7 10841 18 , , , cord-005453-4057qib7 10841 19 Japan Japan NNP cord-005453-4057qib7 10841 20 , , , cord-005453-4057qib7 10841 21 4 4 CD cord-005453-4057qib7 10841 22 National National NNP cord-005453-4057qib7 10841 23 Cancer Cancer NNP cord-005453-4057qib7 10841 24 Institute Institute NNP cord-005453-4057qib7 10841 25 , , , cord-005453-4057qib7 10841 26 Bethesda Bethesda NNP cord-005453-4057qib7 10841 27 , , , cord-005453-4057qib7 10841 28 MD MD NNP cord-005453-4057qib7 10841 29 , , , cord-005453-4057qib7 10841 30 United United NNP cord-005453-4057qib7 10841 31 States States NNP cord-005453-4057qib7 10841 32 , , , cord-005453-4057qib7 10841 33 5 5 CD cord-005453-4057qib7 10841 34 Okayama Okayama NNP cord-005453-4057qib7 10841 35 University University NNP cord-005453-4057qib7 10841 36 Hospital Hospital NNP cord-005453-4057qib7 10841 37 , , , cord-005453-4057qib7 10841 38 Okayama Okayama NNP cord-005453-4057qib7 10841 39 , , , cord-005453-4057qib7 10841 40 Japan Japan NNP cord-005453-4057qib7 10841 41 , , , cord-005453-4057qib7 10841 42 6 6 CD cord-005453-4057qib7 10841 43 Kanazawa Kanazawa NNP cord-005453-4057qib7 10841 44 Medical Medical NNP cord-005453-4057qib7 10841 45 University University NNP cord-005453-4057qib7 10841 46 , , , cord-005453-4057qib7 10841 47 Uchinada Uchinada NNP cord-005453-4057qib7 10841 48 , , , cord-005453-4057qib7 10841 49 Japan Japan NNP cord-005453-4057qib7 10841 50 , , , cord-005453-4057qib7 10841 51 7 7 CD cord-005453-4057qib7 10841 52 Kyoto Kyoto NNP cord-005453-4057qib7 10841 53 University University NNP cord-005453-4057qib7 10841 54 , , , cord-005453-4057qib7 10841 55 Kyoto Kyoto NNP cord-005453-4057qib7 10841 56 , , , cord-005453-4057qib7 10841 57 Japan Japan NNP cord-005453-4057qib7 10841 58 , , , cord-005453-4057qib7 10841 59 8 8 CD cord-005453-4057qib7 10841 60 Aomori Aomori NNP cord-005453-4057qib7 10841 61 Prefectural Prefectural NNP cord-005453-4057qib7 10841 62 Central Central NNP cord-005453-4057qib7 10841 63 Hospital Hospital NNP cord-005453-4057qib7 10841 64 , , , cord-005453-4057qib7 10841 65 Aomori Aomori NNP cord-005453-4057qib7 10841 66 , , , cord-005453-4057qib7 10841 67 Japan Japan NNP cord-005453-4057qib7 10841 68 , , , cord-005453-4057qib7 10841 69 9 9 CD cord-005453-4057qib7 10841 70 Yamagata Yamagata NNP cord-005453-4057qib7 10841 71 Unversity Unversity NNP cord-005453-4057qib7 10841 72 School School NNP cord-005453-4057qib7 10841 73 of of IN cord-005453-4057qib7 10841 74 Medicine Medicine NNP cord-005453-4057qib7 10841 75 , , , cord-005453-4057qib7 10841 76 Yamagata Yamagata NNP cord-005453-4057qib7 10841 77 , , , cord-005453-4057qib7 10841 78 Japan Japan NNP cord-005453-4057qib7 10841 79 , , , cord-005453-4057qib7 10841 80 10 10 CD cord-005453-4057qib7 10841 81 Tenri Tenri NNP cord-005453-4057qib7 10841 82 Hospital Hospital NNP cord-005453-4057qib7 10841 83 , , , cord-005453-4057qib7 10841 84 Tenri Tenri NNP cord-005453-4057qib7 10841 85 , , , cord-005453-4057qib7 10841 86 Japan Japan NNP cord-005453-4057qib7 10841 87 , , , cord-005453-4057qib7 10841 88 11 11 CD cord-005453-4057qib7 10841 89 Hiroshima Hiroshima NNP cord-005453-4057qib7 10841 90 University University NNP cord-005453-4057qib7 10841 91 , , , cord-005453-4057qib7 10841 92 Hiroshima Hiroshima NNP cord-005453-4057qib7 10841 93 , , , cord-005453-4057qib7 10841 94 Japan Japan NNP cord-005453-4057qib7 10841 95 , , , cord-005453-4057qib7 10841 96 12 12 CD cord-005453-4057qib7 10841 97 Japanese Japanese NNP cord-005453-4057qib7 10841 98 Data Data NNPS cord-005453-4057qib7 10841 99 Center Center NNP cord-005453-4057qib7 10841 100 for for IN cord-005453-4057qib7 10841 101 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 10841 102 Cell Cell NNP cord-005453-4057qib7 10841 103 Transplantation Transplantation NNP cord-005453-4057qib7 10841 104 , , , cord-005453-4057qib7 10841 105 Nagoya Nagoya NNP cord-005453-4057qib7 10841 106 , , , cord-005453-4057qib7 10841 107 Japan Japan NNP cord-005453-4057qib7 10841 108 , , , cord-005453-4057qib7 10841 109 13 13 CD cord-005453-4057qib7 10841 110 Nagoya Nagoya NNP cord-005453-4057qib7 10841 111 University University NNP cord-005453-4057qib7 10841 112 Graduate Graduate NNP cord-005453-4057qib7 10841 113 School School NNP cord-005453-4057qib7 10841 114 of of IN cord-005453-4057qib7 10841 115 Medicine Medicine NNP cord-005453-4057qib7 10841 116 , , , cord-005453-4057qib7 10841 117 Nagoya Nagoya NNP cord-005453-4057qib7 10841 118 , , , cord-005453-4057qib7 10841 119 Japan Japan NNP cord-005453-4057qib7 10841 120 , , , cord-005453-4057qib7 10841 121 14 14 CD cord-005453-4057qib7 10841 122 Shimane Shimane NNP cord-005453-4057qib7 10841 123 University University NNP cord-005453-4057qib7 10841 124 Hospital Hospital NNP cord-005453-4057qib7 10841 125 , , , cord-005453-4057qib7 10841 126 Izumo Izumo NNP cord-005453-4057qib7 10841 127 , , , cord-005453-4057qib7 10842 1 Japan Japan NNP cord-005453-4057qib7 10842 2 Background Background NNP cord-005453-4057qib7 10842 3 : : : cord-005453-4057qib7 10842 4 High high JJ cord-005453-4057qib7 10842 5 - - HYPH cord-005453-4057qib7 10842 6 dose dose NN cord-005453-4057qib7 10842 7 chemotherapy chemotherapy NN cord-005453-4057qib7 10842 8 ( ( -LRB- cord-005453-4057qib7 10842 9 HDT HDT NNP cord-005453-4057qib7 10842 10 ) ) -RRB- cord-005453-4057qib7 10842 11 with with IN cord-005453-4057qib7 10842 12 autologous autologous JJ cord-005453-4057qib7 10842 13 stem stem NN cord-005453-4057qib7 10842 14 cell cell NN cord-005453-4057qib7 10842 15 transplantation transplantation NN cord-005453-4057qib7 10842 16 ( ( -LRB- cord-005453-4057qib7 10842 17 ASCT ASCT NNP cord-005453-4057qib7 10842 18 ) ) -RRB- cord-005453-4057qib7 10842 19 has have VBZ cord-005453-4057qib7 10842 20 been be VBN cord-005453-4057qib7 10842 21 shown show VBN cord-005453-4057qib7 10842 22 to to TO cord-005453-4057qib7 10842 23 improve improve VB cord-005453-4057qib7 10842 24 prognosis prognosis NN cord-005453-4057qib7 10842 25 of of IN cord-005453-4057qib7 10842 26 patients patient NNS cord-005453-4057qib7 10842 27 with with IN cord-005453-4057qib7 10842 28 central central JJ cord-005453-4057qib7 10842 29 nervous nervous JJ cord-005453-4057qib7 10842 30 system system NN cord-005453-4057qib7 10842 31 ( ( -LRB- cord-005453-4057qib7 10842 32 CNS CNS NNP cord-005453-4057qib7 10842 33 ) ) -RRB- cord-005453-4057qib7 10842 34 lymphoma lymphoma NN cord-005453-4057qib7 10842 35 . . . cord-005453-4057qib7 10843 1 Whereas whereas IN cord-005453-4057qib7 10843 2 the the DT cord-005453-4057qib7 10843 3 common common JJ cord-005453-4057qib7 10843 4 regimen regimen NN cord-005453-4057qib7 10843 5 of of IN cord-005453-4057qib7 10843 6 HDT HDT NNP cord-005453-4057qib7 10843 7 for for IN cord-005453-4057qib7 10843 8 PCNSL PCNSL NNP cord-005453-4057qib7 10843 9 in in IN cord-005453-4057qib7 10843 10 the the DT cord-005453-4057qib7 10843 11 Europe Europe NNP cord-005453-4057qib7 10843 12 and and CC cord-005453-4057qib7 10843 13 the the DT cord-005453-4057qib7 10843 14 US US NNP cord-005453-4057qib7 10843 15 is be VBZ cord-005453-4057qib7 10843 16 thiotepa thiotepa RB cord-005453-4057qib7 10843 17 - - HYPH cord-005453-4057qib7 10843 18 based base VBN cord-005453-4057qib7 10843 19 regimen regimen NN cord-005453-4057qib7 10843 20 , , , cord-005453-4057qib7 10843 21 e.g. e.g. RB cord-005453-4057qib7 10843 22 BCNU BCNU NNP cord-005453-4057qib7 10843 23 - - HYPH cord-005453-4057qib7 10843 24 Thiotepa Thiotepa NNP cord-005453-4057qib7 10843 25 , , , cord-005453-4057qib7 10844 1 TBC TBC NNP cord-005453-4057qib7 10844 2 ( ( -LRB- cord-005453-4057qib7 10844 3 Thiotepa Thiotepa NNP cord-005453-4057qib7 10844 4 - - HYPH cord-005453-4057qib7 10844 5 Busulfan Busulfan NNP cord-005453-4057qib7 10844 6 - - HYPH cord-005453-4057qib7 10844 7 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 10844 8 ) ) -RRB- cord-005453-4057qib7 10844 9 , , , cord-005453-4057qib7 10844 10 thiotepa thiotepa RB cord-005453-4057qib7 10844 11 - - HYPH cord-005453-4057qib7 10844 12 based base VBN cord-005453-4057qib7 10844 13 regimen regimen NN cord-005453-4057qib7 10844 14 was be VBD cord-005453-4057qib7 10844 15 only only RB cord-005453-4057qib7 10844 16 available available JJ cord-005453-4057qib7 10844 17 before before IN cord-005453-4057qib7 10844 18 discontinuation discontinuation NN cord-005453-4057qib7 10844 19 of of IN cord-005453-4057qib7 10844 20 thiotepa thiotepa NNS cord-005453-4057qib7 10844 21 in in IN cord-005453-4057qib7 10844 22 2009 2009 CD cord-005453-4057qib7 10844 23 in in IN cord-005453-4057qib7 10844 24 Japan Japan NNP cord-005453-4057qib7 10844 25 . . . cord-005453-4057qib7 10845 1 We -PRON- PRP cord-005453-4057qib7 10845 2 report report VBP cord-005453-4057qib7 10845 3 the the DT cord-005453-4057qib7 10845 4 results result NNS cord-005453-4057qib7 10845 5 of of IN cord-005453-4057qib7 10845 6 ASCT ASCT NNP cord-005453-4057qib7 10845 7 for for IN cord-005453-4057qib7 10845 8 PCNSL PCNSL NNP cord-005453-4057qib7 10845 9 from from IN cord-005453-4057qib7 10845 10 the the DT cord-005453-4057qib7 10845 11 Japan Japan NNP cord-005453-4057qib7 10845 12 Society Society NNP cord-005453-4057qib7 10845 13 for for IN cord-005453-4057qib7 10845 14 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 10845 15 Cell Cell NNP cord-005453-4057qib7 10845 16 Transplantation Transplantation NNP cord-005453-4057qib7 10845 17 ( ( -LRB- cord-005453-4057qib7 10845 18 JSHCT JSHCT NNP cord-005453-4057qib7 10845 19 ) ) -RRB- cord-005453-4057qib7 10845 20 Registry Registry NNP cord-005453-4057qib7 10845 21 . . . cord-005453-4057qib7 10846 1 Methods method NNS cord-005453-4057qib7 10846 2 : : : cord-005453-4057qib7 10847 1 Data datum NNS cord-005453-4057qib7 10847 2 from from IN cord-005453-4057qib7 10847 3 the the DT cord-005453-4057qib7 10847 4 JSHCT JSHCT NNP cord-005453-4057qib7 10847 5 registry registry NN cord-005453-4057qib7 10847 6 were be VBD cord-005453-4057qib7 10847 7 retrospectively retrospectively RB cord-005453-4057qib7 10847 8 analyzed analyze VBN cord-005453-4057qib7 10847 9 . . . cord-005453-4057qib7 10848 1 102 102 CD cord-005453-4057qib7 10848 2 patients patient NNS cord-005453-4057qib7 10848 3 with with IN cord-005453-4057qib7 10848 4 PCNSL PCNSL NNP cord-005453-4057qib7 10848 5 who who WP cord-005453-4057qib7 10848 6 received receive VBD cord-005453-4057qib7 10848 7 first first JJ cord-005453-4057qib7 10848 8 HDT HDT NNP cord-005453-4057qib7 10848 9 / / SYM cord-005453-4057qib7 10848 10 ASCT ASCT NNP cord-005453-4057qib7 10848 11 between between IN cord-005453-4057qib7 10848 12 2006 2006 CD cord-005453-4057qib7 10848 13 and and CC cord-005453-4057qib7 10848 14 2015 2015 CD cord-005453-4057qib7 10848 15 were be VBD cord-005453-4057qib7 10848 16 evaluated evaluate VBN cord-005453-4057qib7 10848 17 . . . cord-005453-4057qib7 10849 1 Distribution distribution NN cord-005453-4057qib7 10849 2 differences difference NNS cord-005453-4057qib7 10849 3 of of IN cord-005453-4057qib7 10849 4 clinical clinical JJ cord-005453-4057qib7 10849 5 characteristics characteristic NNS cord-005453-4057qib7 10849 6 between between IN cord-005453-4057qib7 10849 7 groups group NNS cord-005453-4057qib7 10849 8 were be VBD cord-005453-4057qib7 10849 9 analyzed analyze VBN cord-005453-4057qib7 10849 10 with with IN cord-005453-4057qib7 10849 11 Fisher´s fisher´s JJ cord-005453-4057qib7 10849 12 exact exact NN cord-005453-4057qib7 10849 13 or or CC cord-005453-4057qib7 10849 14 Mann Mann NNP cord-005453-4057qib7 10849 15 - - HYPH cord-005453-4057qib7 10849 16 Whitney Whitney NNP cord-005453-4057qib7 10849 17 U U NNP cord-005453-4057qib7 10849 18 tests test VBZ cord-005453-4057qib7 10849 19 . . . cord-005453-4057qib7 10850 1 Overall overall JJ cord-005453-4057qib7 10850 2 survival survival NN cord-005453-4057qib7 10850 3 ( ( -LRB- cord-005453-4057qib7 10850 4 OS OS NNP cord-005453-4057qib7 10850 5 ) ) -RRB- cord-005453-4057qib7 10850 6 and and CC cord-005453-4057qib7 10850 7 progression progression NN cord-005453-4057qib7 10850 8 free free JJ cord-005453-4057qib7 10850 9 survival survival NN cord-005453-4057qib7 10850 10 ( ( -LRB- cord-005453-4057qib7 10850 11 PFS PFS NNP cord-005453-4057qib7 10850 12 ) ) -RRB- cord-005453-4057qib7 10850 13 were be VBD cord-005453-4057qib7 10850 14 calculated calculate VBN cord-005453-4057qib7 10850 15 using use VBG cord-005453-4057qib7 10850 16 Kaplan Kaplan NNP cord-005453-4057qib7 10850 17 - - HYPH cord-005453-4057qib7 10850 18 Meier Meier NNP cord-005453-4057qib7 10850 19 method method NN cord-005453-4057qib7 10850 20 . . . cord-005453-4057qib7 10851 1 Two two CD cord-005453-4057qib7 10851 2 - - HYPH cord-005453-4057qib7 10851 3 group group NN cord-005453-4057qib7 10851 4 analysis analysis NN cord-005453-4057qib7 10851 5 of of IN cord-005453-4057qib7 10851 6 the the DT cord-005453-4057qib7 10851 7 cumulative cumulative JJ cord-005453-4057qib7 10851 8 incidence incidence NN cord-005453-4057qib7 10851 9 of of IN cord-005453-4057qib7 10851 10 relapse relapse NN cord-005453-4057qib7 10851 11 was be VBD cord-005453-4057qib7 10851 12 conducted conduct VBN cord-005453-4057qib7 10851 13 using use VBG cord-005453-4057qib7 10851 14 the the DT cord-005453-4057qib7 10851 15 Grey Grey NNP cord-005453-4057qib7 10851 16 test test NN cord-005453-4057qib7 10851 17 . . . cord-005453-4057qib7 10852 1 Factors factor NNS cord-005453-4057qib7 10852 2 were be VBD cord-005453-4057qib7 10852 3 analyzed analyze VBN cord-005453-4057qib7 10852 4 in in IN cord-005453-4057qib7 10852 5 univariable univariable JJ cord-005453-4057qib7 10852 6 analysis analysis NN cord-005453-4057qib7 10852 7 , , , cord-005453-4057qib7 10852 8 and and CC cord-005453-4057qib7 10852 9 all all DT cord-005453-4057qib7 10852 10 factors factor NNS cord-005453-4057qib7 10852 11 with with IN cord-005453-4057qib7 10852 12 P≤.1 P≤.1 NNS cord-005453-4057qib7 10852 13 were be VBD cord-005453-4057qib7 10852 14 retained retain VBN cord-005453-4057qib7 10852 15 in in IN cord-005453-4057qib7 10852 16 the the DT cord-005453-4057qib7 10852 17 multivariable multivariable JJ cord-005453-4057qib7 10852 18 model model NN cord-005453-4057qib7 10852 19 . . . cord-005453-4057qib7 10853 1 All all DT cord-005453-4057qib7 10853 2 P p NN cord-005453-4057qib7 10853 3 values value NNS cord-005453-4057qib7 10853 4 were be VBD cord-005453-4057qib7 10853 5 2 2 CD cord-005453-4057qib7 10853 6 sided sided JJ cord-005453-4057qib7 10853 7 , , , cord-005453-4057qib7 10853 8 and and CC cord-005453-4057qib7 10853 9 values value NNS cord-005453-4057qib7 10853 10 were be VBD cord-005453-4057qib7 10853 11 regarded regard VBN cord-005453-4057qib7 10853 12 statistically statistically RB cord-005453-4057qib7 10853 13 significant significant JJ cord-005453-4057qib7 10853 14 if if IN cord-005453-4057qib7 10853 15 P p NN cord-005453-4057qib7 10853 16 < < XX cord-005453-4057qib7 10853 17 .05 .05 NFP cord-005453-4057qib7 10853 18 . . . cord-005453-4057qib7 10854 1 Results result NNS cord-005453-4057qib7 10854 2 : : : cord-005453-4057qib7 10855 1 Median median JJ cord-005453-4057qib7 10855 2 age age NN cord-005453-4057qib7 10855 3 was be VBD cord-005453-4057qib7 10855 4 54 54 CD cord-005453-4057qib7 10855 5 months month NNS cord-005453-4057qib7 10856 1 ( ( -LRB- cord-005453-4057qib7 10856 2 range range NN cord-005453-4057qib7 10856 3 20 20 CD cord-005453-4057qib7 10856 4 - - SYM cord-005453-4057qib7 10856 5 74 74 CD cord-005453-4057qib7 10856 6 ) ) -RRB- cord-005453-4057qib7 10856 7 with with IN cord-005453-4057qib7 10856 8 15 15 CD cord-005453-4057qib7 10856 9 patients patient NNS cord-005453-4057qib7 10856 10 over over IN cord-005453-4057qib7 10856 11 64 64 CD cord-005453-4057qib7 10856 12 years year NNS cord-005453-4057qib7 10856 13 of of IN cord-005453-4057qib7 10856 14 age age NN cord-005453-4057qib7 10856 15 ; ; : cord-005453-4057qib7 10856 16 38 38 CD cord-005453-4057qib7 10856 17 males male NNS cord-005453-4057qib7 10856 18 and and CC cord-005453-4057qib7 10856 19 64 64 CD cord-005453-4057qib7 10856 20 females female NNS cord-005453-4057qib7 10856 21 . . . cord-005453-4057qib7 10857 1 ECOG ECOG NNP cord-005453-4057qib7 10857 2 - - HYPH cord-005453-4057qib7 10857 3 Performance Performance NNP cord-005453-4057qib7 10857 4 Status status NN cord-005453-4057qib7 10857 5 ( ( -LRB- cord-005453-4057qib7 10857 6 PS PS NNP cord-005453-4057qib7 10857 7 ) ) -RRB- cord-005453-4057qib7 10857 8 at at IN cord-005453-4057qib7 10857 9 diagnosis diagnosis NN cord-005453-4057qib7 10857 10 was be VBD cord-005453-4057qib7 10857 11 better well JJR cord-005453-4057qib7 10858 1 ( ( -LRB- cord-005453-4057qib7 10858 2 PS0 PS0 NNP cord-005453-4057qib7 10858 3 - - HYPH cord-005453-4057qib7 10858 4 1 1 CD cord-005453-4057qib7 10858 5 ) ) -RRB- cord-005453-4057qib7 10859 1 in in IN cord-005453-4057qib7 10859 2 86 86 CD cord-005453-4057qib7 10859 3 patients patient NNS cord-005453-4057qib7 10859 4 and and CC cord-005453-4057qib7 10859 5 poor poor JJ cord-005453-4057qib7 10859 6 ( ( -LRB- cord-005453-4057qib7 10859 7 PS2 PS2 NNP cord-005453-4057qib7 10859 8 - - HYPH cord-005453-4057qib7 10859 9 4 4 CD cord-005453-4057qib7 10859 10 ) ) -RRB- cord-005453-4057qib7 10859 11 in in IN cord-005453-4057qib7 10859 12 16 16 CD cord-005453-4057qib7 10859 13 patients patient NNS cord-005453-4057qib7 10859 14 . . . cord-005453-4057qib7 10860 1 Serum serum NN cord-005453-4057qib7 10860 2 lactate lactate NN cord-005453-4057qib7 10860 3 dehydrogenase dehydrogenase NN cord-005453-4057qib7 10860 4 ( ( -LRB- cord-005453-4057qib7 10860 5 LDH LDH NNP cord-005453-4057qib7 10860 6 ) ) -RRB- cord-005453-4057qib7 10860 7 levels level NNS cord-005453-4057qib7 10860 8 at at IN cord-005453-4057qib7 10860 9 diagnosis diagnosis NN cord-005453-4057qib7 10860 10 were be VBD cord-005453-4057qib7 10860 11 elevated elevate VBN cord-005453-4057qib7 10860 12 in in IN cord-005453-4057qib7 10860 13 17 17 CD cord-005453-4057qib7 10860 14 patients patient NNS cord-005453-4057qib7 10860 15 . . . cord-005453-4057qib7 10861 1 Karnofsky Karnofsky NNP cord-005453-4057qib7 10861 2 PS PS NNP cord-005453-4057qib7 10861 3 and and CC cord-005453-4057qib7 10861 4 Cerebrospinal cerebrospinal NN cord-005453-4057qib7 10861 5 fluid fluid NN cord-005453-4057qib7 10861 6 ( ( -LRB- cord-005453-4057qib7 10861 7 CSF CSF NNP cord-005453-4057qib7 10861 8 ) ) -RRB- cord-005453-4057qib7 10861 9 protein protein NN cord-005453-4057qib7 10861 10 concentration concentration NN cord-005453-4057qib7 10861 11 at at IN cord-005453-4057qib7 10861 12 diagnosis diagnosis NN cord-005453-4057qib7 10861 13 were be VBD cord-005453-4057qib7 10861 14 not not RB cord-005453-4057qib7 10861 15 collected collect VBN cord-005453-4057qib7 10861 16 in in IN cord-005453-4057qib7 10861 17 the the DT cord-005453-4057qib7 10861 18 registry registry NN cord-005453-4057qib7 10861 19 . . . cord-005453-4057qib7 10862 1 71 71 CD cord-005453-4057qib7 10862 2 patients patient NNS cord-005453-4057qib7 10862 3 were be VBD cord-005453-4057qib7 10862 4 in in IN cord-005453-4057qib7 10862 5 complete complete JJ cord-005453-4057qib7 10862 6 remission remission NN cord-005453-4057qib7 10862 7 ( ( -LRB- cord-005453-4057qib7 10862 8 CR CR NNP cord-005453-4057qib7 10862 9 ) ) -RRB- cord-005453-4057qib7 10862 10 , , , cord-005453-4057qib7 10862 11 21 21 CD cord-005453-4057qib7 10862 12 patients patient NNS cord-005453-4057qib7 10862 13 were be VBD cord-005453-4057qib7 10862 14 in in IN cord-005453-4057qib7 10862 15 partial partial JJ cord-005453-4057qib7 10862 16 response response NN cord-005453-4057qib7 10862 17 ( ( -LRB- cord-005453-4057qib7 10862 18 PR PR NNP cord-005453-4057qib7 10862 19 ) ) -RRB- cord-005453-4057qib7 10862 20 , , , cord-005453-4057qib7 10862 21 and and CC cord-005453-4057qib7 10862 22 7 7 CD cord-005453-4057qib7 10862 23 patients patient NNS cord-005453-4057qib7 10862 24 were be VBD cord-005453-4057qib7 10862 25 stable stable JJ cord-005453-4057qib7 10862 26 disease disease NN cord-005453-4057qib7 10862 27 ( ( -LRB- cord-005453-4057qib7 10862 28 SD SD NNP cord-005453-4057qib7 10862 29 ) ) -RRB- cord-005453-4057qib7 10862 30 or or CC cord-005453-4057qib7 10862 31 progressive progressive JJ cord-005453-4057qib7 10862 32 disease disease NN cord-005453-4057qib7 10862 33 ( ( -LRB- cord-005453-4057qib7 10862 34 PD PD NNP cord-005453-4057qib7 10862 35 ) ) -RRB- cord-005453-4057qib7 10862 36 at at IN cord-005453-4057qib7 10862 37 the the DT cord-005453-4057qib7 10862 38 time time NN cord-005453-4057qib7 10862 39 of of IN cord-005453-4057qib7 10862 40 HDT HDT NNP cord-005453-4057qib7 10862 41 / / SYM cord-005453-4057qib7 10862 42 ASCT ASCT NNP cord-005453-4057qib7 10862 43 . . . cord-005453-4057qib7 10863 1 After after IN cord-005453-4057qib7 10863 2 HDT HDT NNP cord-005453-4057qib7 10863 3 / / SYM cord-005453-4057qib7 10863 4 ASCT ASCT NNP cord-005453-4057qib7 10863 5 , , , cord-005453-4057qib7 10863 6 additional additional JJ cord-005453-4057qib7 10863 7 20 20 CD cord-005453-4057qib7 10863 8 patients patient NNS cord-005453-4057qib7 10863 9 achieved achieve VBD cord-005453-4057qib7 10863 10 CR CR NNP cord-005453-4057qib7 10863 11 . . . cord-005453-4057qib7 10864 1 With with IN cord-005453-4057qib7 10864 2 median median JJ cord-005453-4057qib7 10864 3 follow follow NN cord-005453-4057qib7 10864 4 - - HYPH cord-005453-4057qib7 10864 5 up up NN cord-005453-4057qib7 10864 6 period period NN cord-005453-4057qib7 10864 7 of of IN cord-005453-4057qib7 10864 8 44 44 CD cord-005453-4057qib7 10864 9 months month NNS cord-005453-4057qib7 10864 10 , , , cord-005453-4057qib7 10864 11 the the DT cord-005453-4057qib7 10864 12 5-year 5-year CD cord-005453-4057qib7 10864 13 OS OS NNP cord-005453-4057qib7 10864 14 and and CC cord-005453-4057qib7 10864 15 PFS PFS NNP cord-005453-4057qib7 10864 16 were be VBD cord-005453-4057qib7 10864 17 54.9 54.9 CD cord-005453-4057qib7 10864 18 % % NN cord-005453-4057qib7 10864 19 and and CC cord-005453-4057qib7 10864 20 38.4 38.4 CD cord-005453-4057qib7 10864 21 % % NN cord-005453-4057qib7 10864 22 , , , cord-005453-4057qib7 10864 23 respectively respectively RB cord-005453-4057qib7 10864 24 . . . cord-005453-4057qib7 10865 1 The the DT cord-005453-4057qib7 10865 2 was be VBD cord-005453-4057qib7 10865 3 no no DT cord-005453-4057qib7 10865 4 significant significant JJ cord-005453-4057qib7 10865 5 difference difference NN cord-005453-4057qib7 10865 6 in in IN cord-005453-4057qib7 10865 7 OS OS NNP cord-005453-4057qib7 10865 8 and and CC cord-005453-4057qib7 10865 9 PFS PFS NNP cord-005453-4057qib7 10865 10 between between IN cord-005453-4057qib7 10865 11 upfront upfront NN cord-005453-4057qib7 10865 12 and and CC cord-005453-4057qib7 10865 13 salvage salvage VB cord-005453-4057qib7 10865 14 HDT HDT NNP cord-005453-4057qib7 10865 15 / / SYM cord-005453-4057qib7 10865 16 ASCT ASCT NNP cord-005453-4057qib7 10865 17 . . . cord-005453-4057qib7 10866 1 Since since IN cord-005453-4057qib7 10866 2 thiotepa thiotepa NNP cord-005453-4057qib7 10866 3 , , , cord-005453-4057qib7 10866 4 a a DT cord-005453-4057qib7 10866 5 key key JJ cord-005453-4057qib7 10866 6 agent agent NN cord-005453-4057qib7 10866 7 in in IN cord-005453-4057qib7 10866 8 HDT HDT NNP cord-005453-4057qib7 10866 9 / / SYM cord-005453-4057qib7 10866 10 ASCT ASCT NNP cord-005453-4057qib7 10866 11 for for IN cord-005453-4057qib7 10866 12 PCNSL PCNSL NNP cord-005453-4057qib7 10866 13 , , , cord-005453-4057qib7 10866 14 has have VBZ cord-005453-4057qib7 10866 15 been be VBN cord-005453-4057qib7 10866 16 unavailable unavailable JJ cord-005453-4057qib7 10866 17 after after IN cord-005453-4057qib7 10866 18 the the DT cord-005453-4057qib7 10866 19 discontinuation discontinuation NN cord-005453-4057qib7 10866 20 in in IN cord-005453-4057qib7 10866 21 Japan Japan NNP cord-005453-4057qib7 10866 22 , , , cord-005453-4057qib7 10866 23 the the DT cord-005453-4057qib7 10866 24 HDT HDT NNP cord-005453-4057qib7 10866 25 regimens regimen NNS cord-005453-4057qib7 10866 26 used use VBN cord-005453-4057qib7 10866 27 were be VBD cord-005453-4057qib7 10866 28 not not RB cord-005453-4057qib7 10866 29 uniform uniform JJ cord-005453-4057qib7 10866 30 . . . cord-005453-4057qib7 10867 1 Thiotepa Thiotepa NNP cord-005453-4057qib7 10867 2 - - HYPH cord-005453-4057qib7 10867 3 containing contain VBG cord-005453-4057qib7 10867 4 HDT HDT NNP cord-005453-4057qib7 10867 5 was be VBD cord-005453-4057qib7 10867 6 received receive VBN cord-005453-4057qib7 10867 7 by by IN cord-005453-4057qib7 10867 8 16 16 CD cord-005453-4057qib7 10867 9 out out IN cord-005453-4057qib7 10867 10 of of IN cord-005453-4057qib7 10867 11 32 32 CD cord-005453-4057qib7 10867 12 patients patient NNS cord-005453-4057qib7 10867 13 before before IN cord-005453-4057qib7 10867 14 2010 2010 CD cord-005453-4057qib7 10867 15 , , , cord-005453-4057qib7 10867 16 but but CC cord-005453-4057qib7 10867 17 by by IN cord-005453-4057qib7 10867 18 2 2 CD cord-005453-4057qib7 10867 19 out out IN cord-005453-4057qib7 10867 20 of of IN cord-005453-4057qib7 10867 21 70 70 CD cord-005453-4057qib7 10867 22 patients patient NNS cord-005453-4057qib7 10867 23 after after IN cord-005453-4057qib7 10867 24 2011 2011 CD cord-005453-4057qib7 10867 25 . . . cord-005453-4057qib7 10868 1 Thiotepa Thiotepa NNP cord-005453-4057qib7 10868 2 - - HYPH cord-005453-4057qib7 10868 3 containing contain VBG cord-005453-4057qib7 10868 4 HDT HDT NNP cord-005453-4057qib7 10868 5 showed show VBD cord-005453-4057qib7 10868 6 improved improve VBN cord-005453-4057qib7 10868 7 PFS PFS NNP cord-005453-4057qib7 10868 8 ( ( -LRB- cord-005453-4057qib7 10868 9 P=.019 P=.019 NNP cord-005453-4057qib7 10868 10 ) ) -RRB- cord-005453-4057qib7 10868 11 , , , cord-005453-4057qib7 10868 12 lower low JJR cord-005453-4057qib7 10868 13 relapse relapse NN cord-005453-4057qib7 10868 14 ( ( -LRB- cord-005453-4057qib7 10868 15 P=.042 P=.042 NNP cord-005453-4057qib7 10868 16 ) ) -RRB- cord-005453-4057qib7 10868 17 and and CC cord-005453-4057qib7 10868 18 a a DT cord-005453-4057qib7 10868 19 trend trend NN cord-005453-4057qib7 10868 20 toward toward IN cord-005453-4057qib7 10868 21 a a DT cord-005453-4057qib7 10868 22 survival survival NN cord-005453-4057qib7 10868 23 benefit benefit NN cord-005453-4057qib7 10868 24 . . . cord-005453-4057qib7 10869 1 In in IN cord-005453-4057qib7 10869 2 the the DT cord-005453-4057qib7 10869 3 multivariate multivariate JJ cord-005453-4057qib7 10869 4 analysis analysis NN cord-005453-4057qib7 10869 5 , , , cord-005453-4057qib7 10869 6 non non JJ cord-005453-4057qib7 10869 7 - - JJ cord-005453-4057qib7 10869 8 complete complete JJ cord-005453-4057qib7 10869 9 remission remission NN cord-005453-4057qib7 10869 10 at at IN cord-005453-4057qib7 10869 11 HDT HDT NNP cord-005453-4057qib7 10869 12 / / SYM cord-005453-4057qib7 10869 13 ASCT ASCT NNP cord-005453-4057qib7 10869 14 was be VBD cord-005453-4057qib7 10869 15 an an DT cord-005453-4057qib7 10869 16 independent independent JJ cord-005453-4057qib7 10869 17 predictor predictor NN cord-005453-4057qib7 10869 18 for for IN cord-005453-4057qib7 10869 19 OS OS NNP cord-005453-4057qib7 10869 20 ( ( -LRB- cord-005453-4057qib7 10869 21 HR=2.40 HR=2.40 NNP cord-005453-4057qib7 10869 22 , , , cord-005453-4057qib7 10869 23 95%CI:1.25 95%ci:1.25 CD cord-005453-4057qib7 10869 24 - - SYM cord-005453-4057qib7 10869 25 4.58 4.58 CD cord-005453-4057qib7 10869 26 , , , cord-005453-4057qib7 10869 27 P=.008 p=.008 NN cord-005453-4057qib7 10869 28 ) ) -RRB- cord-005453-4057qib7 10869 29 and and CC cord-005453-4057qib7 10869 30 thiotepacontaining thiotepacontaine VBG cord-005453-4057qib7 10869 31 HDT HDT NNP cord-005453-4057qib7 10869 32 remained remain VBD cord-005453-4057qib7 10869 33 significant significant JJ cord-005453-4057qib7 10869 34 for for IN cord-005453-4057qib7 10869 35 PFS PFS NNP cord-005453-4057qib7 10869 36 ( ( -LRB- cord-005453-4057qib7 10869 37 HR=0.42 HR=0.42 NNP cord-005453-4057qib7 10869 38 , , , cord-005453-4057qib7 10869 39 95%CI:0.19 95%ci:0.19 CD cord-005453-4057qib7 10869 40 - - SYM cord-005453-4057qib7 10869 41 0.95 0.95 CD cord-005453-4057qib7 10869 42 , , , cord-005453-4057qib7 10869 43 P=.038 P=.038 NNP cord-005453-4057qib7 10869 44 ) ) -RRB- cord-005453-4057qib7 10869 45 . . . cord-005453-4057qib7 10870 1 [ [ -LRB- cord-005453-4057qib7 10870 2 [ [ -LRB- cord-005453-4057qib7 10870 3 P481 P481 NNP cord-005453-4057qib7 10870 4 Image Image NNP cord-005453-4057qib7 10870 5 ] ] -RRB- cord-005453-4057qib7 10870 6 1 1 CD cord-005453-4057qib7 10870 7 . . . cord-005453-4057qib7 10871 1 OS(A),PFS(B os(a),pfs(b LS cord-005453-4057qib7 10871 2 ) ) -RRB- cord-005453-4057qib7 10872 1 in in IN cord-005453-4057qib7 10872 2 all all DT cord-005453-4057qib7 10872 3 patients patient NNS cord-005453-4057qib7 10872 4 ( ( -LRB- cord-005453-4057qib7 10872 5 n=102 n=102 UH cord-005453-4057qib7 10872 6 ) ) -RRB- cord-005453-4057qib7 10872 7 and and CC cord-005453-4057qib7 10872 8 cumulative cumulative JJ cord-005453-4057qib7 10872 9 incidence incidence NN cord-005453-4057qib7 10872 10 of of IN cord-005453-4057qib7 10872 11 relapse relapse NN cord-005453-4057qib7 10872 12 in in IN cord-005453-4057qib7 10872 13 CR CR NNP cord-005453-4057qib7 10872 14 patients patient NNS cord-005453-4057qib7 10872 15 ( ( -LRB- cord-005453-4057qib7 10872 16 C C NNP cord-005453-4057qib7 10872 17 ; ; : cord-005453-4057qib7 10872 18 n=91 n=91 NNP cord-005453-4057qib7 10872 19 ) ) -RRB- cord-005453-4057qib7 10873 1 ] ] -RRB- cord-005453-4057qib7 10874 1 Conclusions conclusion NNS cord-005453-4057qib7 10874 2 : : : cord-005453-4057qib7 10875 1 Our -PRON- PRP$ cord-005453-4057qib7 10875 2 results result NNS cord-005453-4057qib7 10875 3 confirm confirm VBP cord-005453-4057qib7 10875 4 the the DT cord-005453-4057qib7 10875 5 activity activity NN cord-005453-4057qib7 10875 6 of of IN cord-005453-4057qib7 10875 7 thiotepacontaining thiotepacontaine VBG cord-005453-4057qib7 10875 8 regimen regimen NN cord-005453-4057qib7 10875 9 for for IN cord-005453-4057qib7 10875 10 HDT HDT NNP cord-005453-4057qib7 10875 11 / / SYM cord-005453-4057qib7 10875 12 ASCT ASCT NNP cord-005453-4057qib7 10875 13 in in IN cord-005453-4057qib7 10875 14 PCNSL PCNSL NNP cord-005453-4057qib7 10875 15 patients patient NNS cord-005453-4057qib7 10875 16 . . . cord-005453-4057qib7 10876 1 Currently currently RB cord-005453-4057qib7 10876 2 a a DT cord-005453-4057qib7 10876 3 pharmaceutical pharmaceutical JJ cord-005453-4057qib7 10876 4 company company NN cord-005453-4057qib7 10876 5 re re NN cord-005453-4057qib7 10876 6 - - VBN cord-005453-4057qib7 10876 7 develops develop VBZ cord-005453-4057qib7 10876 8 thiotepa thiotepa NNP cord-005453-4057qib7 10876 9 for for IN cord-005453-4057qib7 10876 10 new new JJ cord-005453-4057qib7 10876 11 approval approval NN cord-005453-4057qib7 10876 12 of of IN cord-005453-4057qib7 10876 13 HDT HDT NNP cord-005453-4057qib7 10876 14 / / SYM cord-005453-4057qib7 10876 15 ASCT ASCT NNP cord-005453-4057qib7 10876 16 in in IN cord-005453-4057qib7 10876 17 pediatric pediatric JJ cord-005453-4057qib7 10876 18 solid solid JJ cord-005453-4057qib7 10876 19 cancer cancer NN cord-005453-4057qib7 10876 20 and and CC cord-005453-4057qib7 10876 21 adult adult NN cord-005453-4057qib7 10876 22 lymphoma lymphoma NN cord-005453-4057qib7 10876 23 in in IN cord-005453-4057qib7 10876 24 Japan Japan NNP cord-005453-4057qib7 10876 25 ( ( -LRB- cord-005453-4057qib7 10876 26 JapicCTI-163433 JapicCTI-163433 NNP cord-005453-4057qib7 10876 27 ) ) -RRB- cord-005453-4057qib7 10876 28 . . . cord-005453-4057qib7 10877 1 Further further JJ cord-005453-4057qib7 10877 2 evaluation evaluation NN cord-005453-4057qib7 10877 3 with with IN cord-005453-4057qib7 10877 4 the the DT cord-005453-4057qib7 10877 5 thiotepa thiotepa NNS cord-005453-4057qib7 10877 6 by by IN cord-005453-4057qib7 10877 7 prospective prospective JJ cord-005453-4057qib7 10877 8 clinical clinical JJ cord-005453-4057qib7 10877 9 trials trial NNS cord-005453-4057qib7 10877 10 is be VBZ cord-005453-4057qib7 10877 11 warranted warrant VBN cord-005453-4057qib7 10877 12 . . . cord-005453-4057qib7 10878 1 Disclosure disclosure NN cord-005453-4057qib7 10878 2 Background background NN cord-005453-4057qib7 10878 3 : : : cord-005453-4057qib7 10878 4 T t NN cord-005453-4057qib7 10878 5 - - HYPH cord-005453-4057qib7 10878 6 cell cell NN cord-005453-4057qib7 10878 7 non non JJ cord-005453-4057qib7 10878 8 - - JJ cord-005453-4057qib7 10878 9 Hodgkin Hodgkin NNP cord-005453-4057qib7 10878 10 lymphomas lymphoma NNS cord-005453-4057qib7 10878 11 ( ( -LRB- cord-005453-4057qib7 10878 12 T T NNP cord-005453-4057qib7 10878 13 - - HYPH cord-005453-4057qib7 10878 14 NHL NHL NNP cord-005453-4057qib7 10878 15 ) ) -RRB- cord-005453-4057qib7 10878 16 are be VBP cord-005453-4057qib7 10878 17 rare rare JJ cord-005453-4057qib7 10878 18 diseases disease NNS cord-005453-4057qib7 10878 19 and and CC cord-005453-4057qib7 10878 20 they -PRON- PRP cord-005453-4057qib7 10878 21 are be VBP cord-005453-4057qib7 10878 22 associated associate VBN cord-005453-4057qib7 10878 23 with with IN cord-005453-4057qib7 10878 24 worse bad JJR cord-005453-4057qib7 10878 25 prognosis prognosis NN cord-005453-4057qib7 10878 26 when when WRB cord-005453-4057qib7 10878 27 compared compare VBN cord-005453-4057qib7 10878 28 to to IN cord-005453-4057qib7 10878 29 their -PRON- PRP$ cord-005453-4057qib7 10878 30 B b NN cord-005453-4057qib7 10878 31 - - HYPH cord-005453-4057qib7 10878 32 cell cell NN cord-005453-4057qib7 10878 33 counterparts counterpart NNS cord-005453-4057qib7 10878 34 . . . cord-005453-4057qib7 10879 1 Allogeneic allogeneic IN cord-005453-4057qib7 10879 2 stem stem VBP cord-005453-4057qib7 10879 3 cell cell NN cord-005453-4057qib7 10879 4 transplantation transplantation NN cord-005453-4057qib7 10879 5 ( ( -LRB- cord-005453-4057qib7 10879 6 allo allo FW cord-005453-4057qib7 10879 7 - - HYPH cord-005453-4057qib7 10879 8 SCT SCT NNP cord-005453-4057qib7 10879 9 ) ) -RRB- cord-005453-4057qib7 10879 10 may may MD cord-005453-4057qib7 10879 11 have have VB cord-005453-4057qib7 10879 12 a a DT cord-005453-4057qib7 10879 13 curative curative JJ cord-005453-4057qib7 10879 14 potential potential NN cord-005453-4057qib7 10879 15 for for IN cord-005453-4057qib7 10879 16 these these DT cord-005453-4057qib7 10879 17 patients patient NNS cord-005453-4057qib7 10879 18 due due JJ cord-005453-4057qib7 10879 19 to to IN cord-005453-4057qib7 10879 20 the the DT cord-005453-4057qib7 10879 21 graft graft NN cord-005453-4057qib7 10879 22 versus versus IN cord-005453-4057qib7 10879 23 lymphoma lymphoma NN cord-005453-4057qib7 10879 24 effect effect NN cord-005453-4057qib7 10879 25 . . . cord-005453-4057qib7 10880 1 However however RB cord-005453-4057qib7 10880 2 , , , cord-005453-4057qib7 10880 3 data datum NNS cord-005453-4057qib7 10880 4 is be VBZ cord-005453-4057qib7 10880 5 limited limit VBN cord-005453-4057qib7 10880 6 on on IN cord-005453-4057qib7 10880 7 the the DT cord-005453-4057qib7 10880 8 efficacy efficacy NN cord-005453-4057qib7 10880 9 of of IN cord-005453-4057qib7 10880 10 allo allo NNP cord-005453-4057qib7 10880 11 - - HYPH cord-005453-4057qib7 10880 12 SCT SCT NNP cord-005453-4057qib7 10880 13 for for IN cord-005453-4057qib7 10880 14 these these DT cord-005453-4057qib7 10880 15 diseases disease NNS cord-005453-4057qib7 10880 16 . . . cord-005453-4057qib7 10881 1 Methods method NNS cord-005453-4057qib7 10881 2 : : : cord-005453-4057qib7 10881 3 We -PRON- PRP cord-005453-4057qib7 10881 4 identified identify VBD cord-005453-4057qib7 10881 5 53 53 CD cord-005453-4057qib7 10881 6 patients patient NNS cord-005453-4057qib7 10881 7 ( ( -LRB- cord-005453-4057qib7 10881 8 32 32 CD cord-005453-4057qib7 10881 9 % % NN cord-005453-4057qib7 10881 10 females female NNS cord-005453-4057qib7 10881 11 ; ; : cord-005453-4057qib7 10881 12 median median JJ cord-005453-4057qib7 10881 13 age age NN cord-005453-4057qib7 10881 14 : : : cord-005453-4057qib7 10881 15 43 43 CD cord-005453-4057qib7 10881 16 y y NN cord-005453-4057qib7 10881 17 ; ; : cord-005453-4057qib7 10881 18 range,4 range,4 NNP cord-005453-4057qib7 10881 19 - - HYPH cord-005453-4057qib7 10881 20 67 67 CD cord-005453-4057qib7 10881 21 ) ) -RRB- cord-005453-4057qib7 10881 22 with with IN cord-005453-4057qib7 10881 23 T T NNP cord-005453-4057qib7 10881 24 - - HYPH cord-005453-4057qib7 10881 25 NHL NHL NNP cord-005453-4057qib7 10881 26 that that WDT cord-005453-4057qib7 10881 27 underwent undergo VBD cord-005453-4057qib7 10881 28 allo allo NN cord-005453-4057qib7 10881 29 - - HYPH cord-005453-4057qib7 10881 30 SCT SCT NNP cord-005453-4057qib7 10881 31 at at IN cord-005453-4057qib7 10881 32 University University NNP cord-005453-4057qib7 10881 33 Hospital Hospital NNP cord-005453-4057qib7 10881 34 Eppendorf Eppendorf NNP cord-005453-4057qib7 10881 35 between between IN cord-005453-4057qib7 10881 36 1992 1992 CD cord-005453-4057qib7 10881 37 and and CC cord-005453-4057qib7 10881 38 2017 2017 CD cord-005453-4057qib7 10881 39 . . . cord-005453-4057qib7 10882 1 Twenty twenty CD cord-005453-4057qib7 10882 2 - - HYPH cord-005453-4057qib7 10882 3 one one CD cord-005453-4057qib7 10882 4 patients patient NNS cord-005453-4057qib7 10882 5 ( ( -LRB- cord-005453-4057qib7 10882 6 underwent undergo VBD cord-005453-4057qib7 10882 7 allo allo NN cord-005453-4057qib7 10882 8 - - HYPH cord-005453-4057qib7 10882 9 SCT SCT NNP cord-005453-4057qib7 10882 10 from from IN cord-005453-4057qib7 10882 11 a a DT cord-005453-4057qib7 10882 12 matched match VBN cord-005453-4057qib7 10882 13 sibling sibling NN cord-005453-4057qib7 10882 14 donor donor NN cord-005453-4057qib7 10882 15 ( ( -LRB- cord-005453-4057qib7 10882 16 MSD MSD NNP cord-005453-4057qib7 10882 17 ) ) -RRB- cord-005453-4057qib7 10882 18 and and CC cord-005453-4057qib7 10882 19 32 32 CD cord-005453-4057qib7 10882 20 ( ( -LRB- cord-005453-4057qib7 10882 21 60 60 CD cord-005453-4057qib7 10882 22 % % NN cord-005453-4057qib7 10882 23 ) ) -RRB- cord-005453-4057qib7 10882 24 from from IN cord-005453-4057qib7 10882 25 a a DT cord-005453-4057qib7 10882 26 matched match VBN cord-005453-4057qib7 10882 27 unrelated unrelated JJ cord-005453-4057qib7 10882 28 donor donor NN cord-005453-4057qib7 10882 29 ( ( -LRB- cord-005453-4057qib7 10882 30 MUD mud NN cord-005453-4057qib7 10882 31 ) ) -RRB- cord-005453-4057qib7 10882 32 . . . cord-005453-4057qib7 10883 1 Sixteen sixteen CD cord-005453-4057qib7 10883 2 patients patient NNS cord-005453-4057qib7 10883 3 had have VBD cord-005453-4057qib7 10883 4 PTCL PTCL NNS cord-005453-4057qib7 10883 5 ( ( -LRB- cord-005453-4057qib7 10883 6 30 30 CD cord-005453-4057qib7 10883 7 % % NN cord-005453-4057qib7 10883 8 ) ) -RRB- cord-005453-4057qib7 10883 9 , , , cord-005453-4057qib7 10883 10 n=8 n=8 NN cord-005453-4057qib7 10883 11 ( ( -LRB- cord-005453-4057qib7 10883 12 15 15 CD cord-005453-4057qib7 10883 13 % % NN cord-005453-4057qib7 10883 14 ) ) -RRB- cord-005453-4057qib7 10883 15 anaplastic anaplastic JJ cord-005453-4057qib7 10883 16 large large JJ cord-005453-4057qib7 10883 17 - - HYPH cord-005453-4057qib7 10883 18 cell cell NN cord-005453-4057qib7 10883 19 lymphoma lymphoma NN cord-005453-4057qib7 10883 20 ( ( -LRB- cord-005453-4057qib7 10883 21 ALCL ALCL NNP cord-005453-4057qib7 10883 22 ) ) -RRB- cord-005453-4057qib7 10883 23 , , , cord-005453-4057qib7 10883 24 n=8 n=8 NN cord-005453-4057qib7 10883 25 ( ( -LRB- cord-005453-4057qib7 10883 26 15 15 CD cord-005453-4057qib7 10883 27 % % NN cord-005453-4057qib7 10883 28 ) ) -RRB- cord-005453-4057qib7 10883 29 angioimmunoblastic angioimmunoblastic JJ cord-005453-4057qib7 10883 30 large large JJ cord-005453-4057qib7 10883 31 cell cell NN cord-005453-4057qib7 10883 32 lymphoma lymphoma NN cord-005453-4057qib7 10883 33 , , , cord-005453-4057qib7 10883 34 n=8 n=8 NN cord-005453-4057qib7 10883 35 ( ( -LRB- cord-005453-4057qib7 10883 36 15 15 CD cord-005453-4057qib7 10883 37 % % NN cord-005453-4057qib7 10883 38 ) ) -RRB- cord-005453-4057qib7 10883 39 adult adult NN cord-005453-4057qib7 10883 40 T t NN cord-005453-4057qib7 10883 41 - - HYPH cord-005453-4057qib7 10883 42 cell cell NN cord-005453-4057qib7 10883 43 leukemia leukemia NN cord-005453-4057qib7 10883 44 / / SYM cord-005453-4057qib7 10883 45 lymphoma lymphoma NN cord-005453-4057qib7 10883 46 , , , cord-005453-4057qib7 10883 47 n=5 n=5 JJ cord-005453-4057qib7 10883 48 ( ( -LRB- cord-005453-4057qib7 10883 49 9 9 CD cord-005453-4057qib7 10883 50 % % NN cord-005453-4057qib7 10883 51 ) ) -RRB- cord-005453-4057qib7 10883 52 hepatosplenic hepatosplenic NNP cord-005453-4057qib7 10883 53 gamma gamma NNP cord-005453-4057qib7 10883 54 / / SYM cord-005453-4057qib7 10883 55 delta delta NNP cord-005453-4057qib7 10883 56 T t NN cord-005453-4057qib7 10883 57 - - HYPH cord-005453-4057qib7 10883 58 cell cell NN cord-005453-4057qib7 10883 59 lymphoma lymphoma NN cord-005453-4057qib7 10883 60 , , , cord-005453-4057qib7 10883 61 n=4 n=4 JJ cord-005453-4057qib7 10883 62 ( ( -LRB- cord-005453-4057qib7 10883 63 8 8 CD cord-005453-4057qib7 10883 64 % % NN cord-005453-4057qib7 10883 65 ) ) -RRB- cord-005453-4057qib7 10883 66 enteropathy enteropathy NNP cord-005453-4057qib7 10883 67 associated associate VBD cord-005453-4057qib7 10883 68 T t NN cord-005453-4057qib7 10883 69 - - HYPH cord-005453-4057qib7 10883 70 cell cell NN cord-005453-4057qib7 10883 71 lymphoma lymphoma NN cord-005453-4057qib7 10883 72 , , , cord-005453-4057qib7 10883 73 n=2 n=2 NNS cord-005453-4057qib7 10883 74 ( ( -LRB- cord-005453-4057qib7 10883 75 4 4 CD cord-005453-4057qib7 10883 76 % % NN cord-005453-4057qib7 10883 77 ) ) -RRB- cord-005453-4057qib7 10884 1 Tcell tcell JJ cord-005453-4057qib7 10884 2 - - HYPH cord-005453-4057qib7 10884 3 prolymphocytic prolymphocytic JJ cord-005453-4057qib7 10884 4 leukemia leukemia NN cord-005453-4057qib7 10884 5 , , , cord-005453-4057qib7 10884 6 and and CC cord-005453-4057qib7 10884 7 n=1 n=1 NN cord-005453-4057qib7 10884 8 ( ( -LRB- cord-005453-4057qib7 10884 9 2 2 CD cord-005453-4057qib7 10884 10 % % NN cord-005453-4057qib7 10884 11 ) ) -RRB- cord-005453-4057qib7 10885 1 each each DT cord-005453-4057qib7 10885 2 extranodal extranodal DT cord-005453-4057qib7 10885 3 T T NNP cord-005453-4057qib7 10885 4 / / SYM cord-005453-4057qib7 10885 5 NK nk NN cord-005453-4057qib7 10885 6 - - HYPH cord-005453-4057qib7 10885 7 cell cell NN cord-005453-4057qib7 10885 8 lymphoma lymphoma NN cord-005453-4057qib7 10885 9 , , , cord-005453-4057qib7 10885 10 cutaneous cutaneous JJ cord-005453-4057qib7 10885 11 T t NN cord-005453-4057qib7 10885 12 - - HYPH cord-005453-4057qib7 10885 13 cell cell NN cord-005453-4057qib7 10885 14 lymphoma lymphoma NN cord-005453-4057qib7 10885 15 as as IN cord-005453-4057qib7 10885 16 underlying underlie VBG cord-005453-4057qib7 10885 17 diagnosis diagnosis NN cord-005453-4057qib7 10885 18 . . . cord-005453-4057qib7 10886 1 The the DT cord-005453-4057qib7 10886 2 median median NN cord-005453-4057qib7 10886 3 Ann Ann NNP cord-005453-4057qib7 10886 4 Arbour Arbour NNP cord-005453-4057qib7 10886 5 stage stage NN cord-005453-4057qib7 10886 6 at at IN cord-005453-4057qib7 10886 7 diagnosis diagnosis NN cord-005453-4057qib7 10886 8 was be VBD cord-005453-4057qib7 10886 9 4 4 CD cord-005453-4057qib7 10887 1 ( ( -LRB- cord-005453-4057qib7 10887 2 range range NN cord-005453-4057qib7 10887 3 , , , cord-005453-4057qib7 10887 4 1 1 CD cord-005453-4057qib7 10887 5 - - SYM cord-005453-4057qib7 10887 6 4 4 CD cord-005453-4057qib7 10887 7 ) ) -RRB- cord-005453-4057qib7 10887 8 . . . cord-005453-4057qib7 10888 1 Ten ten CD cord-005453-4057qib7 10888 2 patients patient NNS cord-005453-4057qib7 10888 3 ( ( -LRB- cord-005453-4057qib7 10888 4 19 19 CD cord-005453-4057qib7 10888 5 % % NN cord-005453-4057qib7 10888 6 ) ) -RRB- cord-005453-4057qib7 10888 7 had have VBD cord-005453-4057qib7 10888 8 bone bone NN cord-005453-4057qib7 10888 9 marrow marrow NN cord-005453-4057qib7 10888 10 involvement involvement NN cord-005453-4057qib7 10888 11 at at IN cord-005453-4057qib7 10888 12 diagnosis diagnosis NN cord-005453-4057qib7 10888 13 . . . cord-005453-4057qib7 10889 1 All all DT cord-005453-4057qib7 10889 2 patients patient NNS cord-005453-4057qib7 10889 3 were be VBD cord-005453-4057qib7 10889 4 heavily heavily RB cord-005453-4057qib7 10889 5 pretreated pretreate VBN cord-005453-4057qib7 10889 6 , , , cord-005453-4057qib7 10889 7 17 17 CD cord-005453-4057qib7 10889 8 ( ( -LRB- cord-005453-4057qib7 10889 9 32 32 CD cord-005453-4057qib7 10889 10 % % NN cord-005453-4057qib7 10889 11 ) ) -RRB- cord-005453-4057qib7 10889 12 patients patient NNS cord-005453-4057qib7 10889 13 relapsed relapse VBD cord-005453-4057qib7 10889 14 post post JJ cord-005453-4057qib7 10889 15 autologous autologous JJ cord-005453-4057qib7 10889 16 stem stem NN cord-005453-4057qib7 10889 17 cell cell NN cord-005453-4057qib7 10889 18 transplant transplant NN cord-005453-4057qib7 10889 19 ( ( -LRB- cord-005453-4057qib7 10889 20 APSCT APSCT NNP cord-005453-4057qib7 10889 21 ) ) -RRB- cord-005453-4057qib7 10889 22 and and CC cord-005453-4057qib7 10889 23 one one CD cord-005453-4057qib7 10889 24 patient patient JJ cord-005453-4057qib7 10889 25 post post FW cord-005453-4057qib7 10889 26 allo allo FW cord-005453-4057qib7 10889 27 - - HYPH cord-005453-4057qib7 10889 28 SCT SCT NNP cord-005453-4057qib7 10889 29 . . . cord-005453-4057qib7 10890 1 Fifteen fifteen CD cord-005453-4057qib7 10890 2 patients patient NNS cord-005453-4057qib7 10890 3 ( ( -LRB- cord-005453-4057qib7 10890 4 28 28 CD cord-005453-4057qib7 10890 5 % % NN cord-005453-4057qib7 10890 6 ) ) -RRB- cord-005453-4057qib7 10890 7 were be VBD cord-005453-4057qib7 10890 8 transplanted transplant VBN cord-005453-4057qib7 10890 9 in in IN cord-005453-4057qib7 10890 10 complete complete JJ cord-005453-4057qib7 10890 11 remission remission NN cord-005453-4057qib7 10890 12 ( ( -LRB- cord-005453-4057qib7 10890 13 CR cr NN cord-005453-4057qib7 10890 14 ) ) -RRB- cord-005453-4057qib7 10890 15 ( ( -LRB- cord-005453-4057qib7 10890 16 10 10 CD cord-005453-4057qib7 10890 17 in in IN cord-005453-4057qib7 10890 18 1 1 CD cord-005453-4057qib7 10890 19 st st NNP cord-005453-4057qib7 10890 20 CR CR NNP cord-005453-4057qib7 10890 21 , , , cord-005453-4057qib7 10890 22 2 2 CD cord-005453-4057qib7 10890 23 in in IN cord-005453-4057qib7 10890 24 2 2 CD cord-005453-4057qib7 10890 25 nd nd NNP cord-005453-4057qib7 10890 26 CR CR NNP cord-005453-4057qib7 10890 27 ) ) -RRB- cord-005453-4057qib7 10890 28 , , . cord-005453-4057qib7 10891 1 n=13 n=13 NNP cord-005453-4057qib7 10891 2 ( ( -LRB- cord-005453-4057qib7 10891 3 25 25 CD cord-005453-4057qib7 10891 4 % % NN cord-005453-4057qib7 10891 5 ) ) -RRB- cord-005453-4057qib7 10892 1 in in IN cord-005453-4057qib7 10892 2 partial partial JJ cord-005453-4057qib7 10892 3 remission remission NN cord-005453-4057qib7 10892 4 ( ( -LRB- cord-005453-4057qib7 10892 5 PR PR NNP cord-005453-4057qib7 10892 6 ) ) -RRB- cord-005453-4057qib7 10892 7 , , , cord-005453-4057qib7 10892 8 and and CC cord-005453-4057qib7 10892 9 n=21 n=21 NN cord-005453-4057qib7 10892 10 ( ( -LRB- cord-005453-4057qib7 10892 11 40 40 CD cord-005453-4057qib7 10892 12 % % NN cord-005453-4057qib7 10892 13 ) ) -RRB- cord-005453-4057qib7 10892 14 with with IN cord-005453-4057qib7 10892 15 advanced advanced JJ cord-005453-4057qib7 10892 16 disease disease NN cord-005453-4057qib7 10892 17 . . . cord-005453-4057qib7 10893 1 Most Most JJS cord-005453-4057qib7 10893 2 of of IN cord-005453-4057qib7 10893 3 the the DT cord-005453-4057qib7 10893 4 patients patient NNS cord-005453-4057qib7 10893 5 received receive VBD cord-005453-4057qib7 10893 6 myeloablative myeloablative JJ cord-005453-4057qib7 10893 7 conditioning conditioning NN cord-005453-4057qib7 10893 8 ( ( -LRB- cord-005453-4057qib7 10893 9 91 91 CD cord-005453-4057qib7 10893 10 % % NN cord-005453-4057qib7 10893 11 ) ) -RRB- cord-005453-4057qib7 10893 12 . . . cord-005453-4057qib7 10894 1 Thirty thirty CD cord-005453-4057qib7 10894 2 - - HYPH cord-005453-4057qib7 10894 3 eight eight CD cord-005453-4057qib7 10894 4 ( ( -LRB- cord-005453-4057qib7 10894 5 72 72 CD cord-005453-4057qib7 10894 6 % % NN cord-005453-4057qib7 10894 7 ) ) -RRB- cord-005453-4057qib7 10894 8 patients patient NNS cord-005453-4057qib7 10894 9 received receive VBD cord-005453-4057qib7 10894 10 Total total JJ cord-005453-4057qib7 10894 11 body body NN cord-005453-4057qib7 10894 12 irradiation irradiation NN cord-005453-4057qib7 10894 13 based base VBN cord-005453-4057qib7 10894 14 regimens regimen NNS cord-005453-4057qib7 10894 15 and and CC cord-005453-4057qib7 10894 16 15 15 CD cord-005453-4057qib7 10894 17 ( ( -LRB- cord-005453-4057qib7 10894 18 28 28 CD cord-005453-4057qib7 10894 19 % % NN cord-005453-4057qib7 10894 20 ) ) -RRB- cord-005453-4057qib7 10894 21 received receive VBD cord-005453-4057qib7 10894 22 chemotherapy chemotherapy NN cord-005453-4057qib7 10894 23 based base VBN cord-005453-4057qib7 10894 24 regimens regimen NNS cord-005453-4057qib7 10894 25 . . . cord-005453-4057qib7 10895 1 Twenty twenty CD cord-005453-4057qib7 10895 2 patients patient NNS cord-005453-4057qib7 10895 3 ( ( -LRB- cord-005453-4057qib7 10895 4 38 38 CD cord-005453-4057qib7 10895 5 % % NN cord-005453-4057qib7 10895 6 ) ) -RRB- cord-005453-4057qib7 10895 7 received receive VBD cord-005453-4057qib7 10895 8 Anti Anti NNP cord-005453-4057qib7 10895 9 - - NNP cord-005453-4057qib7 10895 10 T t JJ cord-005453-4057qib7 10895 11 - - HYPH cord-005453-4057qib7 10895 12 lymphocyte lymphocyte NN cord-005453-4057qib7 10895 13 globulin globulin NN cord-005453-4057qib7 10895 14 ( ( -LRB- cord-005453-4057qib7 10895 15 ATLG ATLG NNP cord-005453-4057qib7 10895 16 Neovii Neovii NNP cord-005453-4057qib7 10895 17 ) ) -RRB- cord-005453-4057qib7 10895 18 , , , cord-005453-4057qib7 10895 19 and and CC cord-005453-4057qib7 10895 20 most most JJS cord-005453-4057qib7 10895 21 patients patient NNS cord-005453-4057qib7 10895 22 ( ( -LRB- cord-005453-4057qib7 10895 23 87 87 CD cord-005453-4057qib7 10895 24 % % NN cord-005453-4057qib7 10895 25 ) ) -RRB- cord-005453-4057qib7 10895 26 received receive VBD cord-005453-4057qib7 10895 27 G G NNP cord-005453-4057qib7 10895 28 - - HYPH cord-005453-4057qib7 10895 29 CSF CSF NNP cord-005453-4057qib7 10895 30 mobilized mobilize VBD cord-005453-4057qib7 10895 31 peripheral peripheral JJ cord-005453-4057qib7 10895 32 stem stem NN cord-005453-4057qib7 10895 33 cells cell NNS cord-005453-4057qib7 10895 34 . . . cord-005453-4057qib7 10896 1 Results result NNS cord-005453-4057qib7 10896 2 : : : cord-005453-4057qib7 10897 1 Overall overall RB cord-005453-4057qib7 10897 2 , , , cord-005453-4057qib7 10897 3 49 49 CD cord-005453-4057qib7 10897 4 patients patient NNS cord-005453-4057qib7 10897 5 ( ( -LRB- cord-005453-4057qib7 10897 6 92 92 CD cord-005453-4057qib7 10897 7 % % NN cord-005453-4057qib7 10897 8 ) ) -RRB- cord-005453-4057qib7 10897 9 had have VBD cord-005453-4057qib7 10897 10 neutrophil neutrophil NN cord-005453-4057qib7 10897 11 engraftment engraftment NN cord-005453-4057qib7 10897 12 ( ( -LRB- cord-005453-4057qib7 10897 13 median median JJ cord-005453-4057qib7 10897 14 days day NNS cord-005453-4057qib7 10897 15 : : : cord-005453-4057qib7 10897 16 13 13 CD cord-005453-4057qib7 10897 17 ; ; : cord-005453-4057qib7 10897 18 range,9 range,9 NNS cord-005453-4057qib7 10897 19 - - HYPH cord-005453-4057qib7 10897 20 36 36 CD cord-005453-4057qib7 10897 21 ) ) -RRB- cord-005453-4057qib7 10897 22 . . . cord-005453-4057qib7 10898 1 At at IN cord-005453-4057qib7 10898 2 day day NN cord-005453-4057qib7 10898 3 100 100 CD cord-005453-4057qib7 10898 4 , , , cord-005453-4057qib7 10898 5 the the DT cord-005453-4057qib7 10898 6 cumulative cumulative JJ cord-005453-4057qib7 10898 7 incidences incidence NNS cord-005453-4057qib7 10898 8 of of IN cord-005453-4057qib7 10898 9 grade grade NN cord-005453-4057qib7 10898 10 II II NNP cord-005453-4057qib7 10898 11 - - HYPH cord-005453-4057qib7 10898 12 IV IV NNP cord-005453-4057qib7 10898 13 and and CC cord-005453-4057qib7 10898 14 grade grade NN cord-005453-4057qib7 10898 15 III III NNP cord-005453-4057qib7 10898 16 - - HYPH cord-005453-4057qib7 10898 17 IV IV NNP cord-005453-4057qib7 10898 18 acute acute JJ cord-005453-4057qib7 10898 19 GVHD GVHD NNP cord-005453-4057qib7 10898 20 were be VBD cord-005453-4057qib7 10898 21 42 42 CD cord-005453-4057qib7 10898 22 % % NN cord-005453-4057qib7 10898 23 and and CC cord-005453-4057qib7 10898 24 15 15 CD cord-005453-4057qib7 10898 25 % % NN cord-005453-4057qib7 10898 26 , , , cord-005453-4057qib7 10898 27 respectively respectively RB cord-005453-4057qib7 10898 28 . . . cord-005453-4057qib7 10899 1 After after IN cord-005453-4057qib7 10899 2 a a DT cord-005453-4057qib7 10899 3 median median NN cord-005453-4057qib7 10899 4 follow follow NN cord-005453-4057qib7 10899 5 up up IN cord-005453-4057qib7 10899 6 of of IN cord-005453-4057qib7 10899 7 12 12 CD cord-005453-4057qib7 10899 8 months month NNS cord-005453-4057qib7 10899 9 ( ( -LRB- cord-005453-4057qib7 10899 10 range range NN cord-005453-4057qib7 10899 11 , , , cord-005453-4057qib7 10899 12 1 1 CD cord-005453-4057qib7 10899 13 - - SYM cord-005453-4057qib7 10899 14 171 171 CD cord-005453-4057qib7 10899 15 ) ) -RRB- cord-005453-4057qib7 10899 16 the the DT cord-005453-4057qib7 10899 17 cumulative cumulative JJ cord-005453-4057qib7 10899 18 incidences incidence NNS cord-005453-4057qib7 10899 19 of of IN cord-005453-4057qib7 10899 20 chronic chronic JJ cord-005453-4057qib7 10899 21 GVHD GVHD NNP cord-005453-4057qib7 10899 22 was be VBD cord-005453-4057qib7 10899 23 12 12 CD cord-005453-4057qib7 10899 24 % % NN cord-005453-4057qib7 10899 25 distributed distribute VBN cord-005453-4057qib7 10899 26 evenly evenly RB cord-005453-4057qib7 10899 27 between between IN cord-005453-4057qib7 10899 28 limited limited JJ cord-005453-4057qib7 10899 29 and and CC cord-005453-4057qib7 10899 30 extensive extensive JJ cord-005453-4057qib7 10899 31 . . . cord-005453-4057qib7 10900 1 Twenty twenty CD cord-005453-4057qib7 10900 2 nine nine CD cord-005453-4057qib7 10900 3 patients patient NNS cord-005453-4057qib7 10900 4 ( ( -LRB- cord-005453-4057qib7 10900 5 55 55 CD cord-005453-4057qib7 10900 6 % % NN cord-005453-4057qib7 10900 7 ) ) -RRB- cord-005453-4057qib7 10900 8 achieved achieve VBD cord-005453-4057qib7 10900 9 CR cr NN cord-005453-4057qib7 10900 10 after after IN cord-005453-4057qib7 10900 11 allo allo NN cord-005453-4057qib7 10900 12 - - HYPH cord-005453-4057qib7 10900 13 SCT SCT NNP cord-005453-4057qib7 10900 14 . . . cord-005453-4057qib7 10901 1 Median median JJ cord-005453-4057qib7 10901 2 overall overall JJ cord-005453-4057qib7 10901 3 survival survival NN cord-005453-4057qib7 10901 4 ( ( -LRB- cord-005453-4057qib7 10901 5 OS OS NNP cord-005453-4057qib7 10901 6 ) ) -RRB- cord-005453-4057qib7 10901 7 and and CC cord-005453-4057qib7 10901 8 disease disease NN cord-005453-4057qib7 10901 9 free free JJ cord-005453-4057qib7 10902 1 ( ( -LRB- cord-005453-4057qib7 10902 2 PFS PFS NNP cord-005453-4057qib7 10902 3 ) ) -RRB- cord-005453-4057qib7 10902 4 survival survival NN cord-005453-4057qib7 10902 5 were be VBD cord-005453-4057qib7 10902 6 44 44 CD cord-005453-4057qib7 10902 7 months month NNS cord-005453-4057qib7 10902 8 and and CC cord-005453-4057qib7 10902 9 12 12 CD cord-005453-4057qib7 10902 10 months month NNS cord-005453-4057qib7 10902 11 respectively respectively RB cord-005453-4057qib7 10902 12 . . . cord-005453-4057qib7 10903 1 The the DT cord-005453-4057qib7 10903 2 3 3 CD cord-005453-4057qib7 10903 3 year year NN cord-005453-4057qib7 10903 4 OS OS NNP cord-005453-4057qib7 10903 5 and and CC cord-005453-4057qib7 10903 6 PFS PFS NNP cord-005453-4057qib7 10903 7 were be VBD cord-005453-4057qib7 10903 8 50 50 CD cord-005453-4057qib7 10903 9 % % NN cord-005453-4057qib7 10903 10 and and CC cord-005453-4057qib7 10903 11 43 43 CD cord-005453-4057qib7 10903 12 % % NN cord-005453-4057qib7 10903 13 respectively respectively RB cord-005453-4057qib7 10903 14 . . . cord-005453-4057qib7 10904 1 Fourteen fourteen CD cord-005453-4057qib7 10904 2 ( ( -LRB- cord-005453-4057qib7 10904 3 26 26 CD cord-005453-4057qib7 10904 4 % % NN cord-005453-4057qib7 10904 5 ; ; : cord-005453-4057qib7 10904 6 95 95 CD cord-005453-4057qib7 10904 7 % % NN cord-005453-4057qib7 10904 8 CI CI NNP cord-005453-4057qib7 10904 9 [ [ -LRB- cord-005453-4057qib7 10904 10 0.15 0.15 CD cord-005453-4057qib7 10904 11 - - HYPH cord-005453-4057qib7 10904 12 0.40 0.40 CD cord-005453-4057qib7 10904 13 ] ] -RRB- cord-005453-4057qib7 10904 14 ) ) -RRB- cord-005453-4057qib7 10904 15 deaths death NNS cord-005453-4057qib7 10904 16 were be VBD cord-005453-4057qib7 10904 17 due due JJ cord-005453-4057qib7 10904 18 to to IN cord-005453-4057qib7 10904 19 non non JJ cord-005453-4057qib7 10904 20 relapse relapse NN cord-005453-4057qib7 10904 21 mortality mortality NN cord-005453-4057qib7 10904 22 ( ( -LRB- cord-005453-4057qib7 10904 23 NRM NRM NNP cord-005453-4057qib7 10904 24 ) ) -RRB- cord-005453-4057qib7 10904 25 and and CC cord-005453-4057qib7 10904 26 15 15 CD cord-005453-4057qib7 10904 27 patients patient NNS cord-005453-4057qib7 10904 28 ( ( -LRB- cord-005453-4057qib7 10904 29 28 28 CD cord-005453-4057qib7 10904 30 % % NN cord-005453-4057qib7 10904 31 ; ; : cord-005453-4057qib7 10904 32 95 95 CD cord-005453-4057qib7 10904 33 % % NN cord-005453-4057qib7 10904 34 CI CI NNP cord-005453-4057qib7 10904 35 [ [ -LRB- cord-005453-4057qib7 10904 36 0.17 0.17 CD cord-005453-4057qib7 10904 37 - - HYPH cord-005453-4057qib7 10904 38 0.42 0.42 CD cord-005453-4057qib7 10904 39 ] ] -RRB- cord-005453-4057qib7 10904 40 ) ) -RRB- cord-005453-4057qib7 10904 41 died die VBD cord-005453-4057qib7 10904 42 due due IN cord-005453-4057qib7 10904 43 to to IN cord-005453-4057qib7 10904 44 disease disease NN cord-005453-4057qib7 10904 45 progression progression NN cord-005453-4057qib7 10904 46 . . . cord-005453-4057qib7 10905 1 Patients patient NNS cord-005453-4057qib7 10905 2 with with IN cord-005453-4057qib7 10905 3 a a DT cord-005453-4057qib7 10905 4 male male JJ cord-005453-4057qib7 10905 5 donor donor NN cord-005453-4057qib7 10905 6 had have VBD cord-005453-4057qib7 10905 7 improved improve VBN cord-005453-4057qib7 10905 8 OS OS NNP cord-005453-4057qib7 10905 9 compared compare VBN cord-005453-4057qib7 10905 10 to to IN cord-005453-4057qib7 10905 11 those those DT cord-005453-4057qib7 10905 12 with with IN cord-005453-4057qib7 10905 13 a a DT cord-005453-4057qib7 10905 14 female female JJ cord-005453-4057qib7 10905 15 donor donor NN cord-005453-4057qib7 10905 16 ( ( -LRB- cord-005453-4057qib7 10905 17 3 3 CD cord-005453-4057qib7 10905 18 year year NN cord-005453-4057qib7 10905 19 OS os NN cord-005453-4057qib7 10905 20 male male JJ cord-005453-4057qib7 10905 21 56 56 CD cord-005453-4057qib7 10905 22 % % NN cord-005453-4057qib7 10905 23 , , , cord-005453-4057qib7 10905 24 Female female JJ cord-005453-4057qib7 10905 25 34 34 CD cord-005453-4057qib7 10905 26 % % NN cord-005453-4057qib7 10905 27 ; ; : cord-005453-4057qib7 10905 28 p=0.038 p=0.038 NNP cord-005453-4057qib7 10905 29 ) ) -RRB- cord-005453-4057qib7 10905 30 . . . cord-005453-4057qib7 10906 1 Patient patient JJ cord-005453-4057qib7 10906 2 gender gender NN cord-005453-4057qib7 10906 3 , , , cord-005453-4057qib7 10906 4 disease disease NN cord-005453-4057qib7 10906 5 subtype subtype NN cord-005453-4057qib7 10906 6 , , , cord-005453-4057qib7 10906 7 bone bone NN cord-005453-4057qib7 10906 8 marrow marrow NN cord-005453-4057qib7 10906 9 involvement involvement NN cord-005453-4057qib7 10906 10 , , , cord-005453-4057qib7 10906 11 type type NN cord-005453-4057qib7 10906 12 of of IN cord-005453-4057qib7 10906 13 allo allo NN cord-005453-4057qib7 10906 14 - - HYPH cord-005453-4057qib7 10906 15 SCT SCT NNP cord-005453-4057qib7 10906 16 , , , cord-005453-4057qib7 10906 17 donor donor NN cord-005453-4057qib7 10906 18 , , , cord-005453-4057qib7 10906 19 patient patient JJ cord-005453-4057qib7 10906 20 CMV CMV NNP cord-005453-4057qib7 10906 21 status status NN cord-005453-4057qib7 10906 22 , , , cord-005453-4057qib7 10906 23 ABO ABO NNP cord-005453-4057qib7 10906 24 incompatibility incompatibility NN cord-005453-4057qib7 10906 25 , , , cord-005453-4057qib7 10906 26 disease disease NN cord-005453-4057qib7 10906 27 stage stage NN cord-005453-4057qib7 10906 28 at at IN cord-005453-4057qib7 10906 29 diagnosis diagnosis NN cord-005453-4057qib7 10906 30 , , , cord-005453-4057qib7 10906 31 previous previous JJ cord-005453-4057qib7 10906 32 transplant transplant NN cord-005453-4057qib7 10906 33 , , , cord-005453-4057qib7 10906 34 disease disease NN cord-005453-4057qib7 10906 35 status status NN cord-005453-4057qib7 10906 36 at at IN cord-005453-4057qib7 10906 37 transplant transplant NN cord-005453-4057qib7 10906 38 , , , cord-005453-4057qib7 10906 39 conditioning conditioning NN cord-005453-4057qib7 10906 40 regimen regimen NN cord-005453-4057qib7 10906 41 , , , cord-005453-4057qib7 10906 42 ATG ATG NNP cord-005453-4057qib7 10906 43 and and CC cord-005453-4057qib7 10906 44 stem stem NN cord-005453-4057qib7 10906 45 cell cell NN cord-005453-4057qib7 10906 46 source source NN cord-005453-4057qib7 10906 47 had have VBD cord-005453-4057qib7 10906 48 no no DT cord-005453-4057qib7 10906 49 effect effect NN cord-005453-4057qib7 10906 50 on on IN cord-005453-4057qib7 10906 51 OS OS NNP cord-005453-4057qib7 10906 52 , , , cord-005453-4057qib7 10906 53 PFS PFS NNP cord-005453-4057qib7 10906 54 , , , cord-005453-4057qib7 10906 55 NRM NRM NNP cord-005453-4057qib7 10906 56 , , , cord-005453-4057qib7 10906 57 and and CC cord-005453-4057qib7 10906 58 post post NN cord-005453-4057qib7 10906 59 transplant transplant NN cord-005453-4057qib7 10906 60 complications complication NNS cord-005453-4057qib7 10906 61 . . . cord-005453-4057qib7 10907 1 Conclusions conclusion NNS cord-005453-4057qib7 10907 2 : : : cord-005453-4057qib7 10908 1 Acknowledging acknowledge VBG cord-005453-4057qib7 10908 2 the the DT cord-005453-4057qib7 10908 3 retrospective retrospective JJ cord-005453-4057qib7 10908 4 nature nature NN cord-005453-4057qib7 10908 5 , , , cord-005453-4057qib7 10908 6 our -PRON- PRP$ cord-005453-4057qib7 10908 7 study study NN cord-005453-4057qib7 10908 8 shows show VBZ cord-005453-4057qib7 10908 9 that that IN cord-005453-4057qib7 10908 10 allo allo NNP cord-005453-4057qib7 10908 11 - - HYPH cord-005453-4057qib7 10908 12 SCT SCT NNP cord-005453-4057qib7 10908 13 induces induce VBZ cord-005453-4057qib7 10908 14 high high JJ cord-005453-4057qib7 10908 15 rates rate NNS cord-005453-4057qib7 10908 16 of of IN cord-005453-4057qib7 10908 17 complete complete JJ cord-005453-4057qib7 10908 18 remission remission NN cord-005453-4057qib7 10908 19 , , , cord-005453-4057qib7 10908 20 and and CC cord-005453-4057qib7 10908 21 may may MD cord-005453-4057qib7 10908 22 have have VB cord-005453-4057qib7 10908 23 a a DT cord-005453-4057qib7 10908 24 curative curative JJ cord-005453-4057qib7 10908 25 potential potential NN cord-005453-4057qib7 10908 26 even even RB cord-005453-4057qib7 10908 27 in in IN cord-005453-4057qib7 10908 28 diseases disease NNS cord-005453-4057qib7 10908 29 relapsing relapse VBG cord-005453-4057qib7 10908 30 post post JJ cord-005453-4057qib7 10908 31 ASCT ASCT NNP cord-005453-4057qib7 10908 32 . . . cord-005453-4057qib7 10909 1 However however RB cord-005453-4057qib7 10909 2 our -PRON- PRP$ cord-005453-4057qib7 10909 3 findings finding NNS cord-005453-4057qib7 10909 4 need need VBP cord-005453-4057qib7 10909 5 to to TO cord-005453-4057qib7 10909 6 be be VB cord-005453-4057qib7 10909 7 confirmed confirm VBN cord-005453-4057qib7 10909 8 in in IN cord-005453-4057qib7 10909 9 larger large JJR cord-005453-4057qib7 10909 10 prospective prospective JJ cord-005453-4057qib7 10909 11 studies study NNS cord-005453-4057qib7 10909 12 . . . cord-005453-4057qib7 10910 1 Disclosure disclosure NN cord-005453-4057qib7 10910 2 : : : cord-005453-4057qib7 10910 3 No no DT cord-005453-4057qib7 10910 4 funding funding NN cord-005453-4057qib7 10910 5 , , , cord-005453-4057qib7 10910 6 no no DT cord-005453-4057qib7 10910 7 conflict conflict NN cord-005453-4057qib7 10910 8 of of IN cord-005453-4057qib7 10910 9 interest interest NN cord-005453-4057qib7 10910 10 P483 P483 NNP cord-005453-4057qib7 10910 11 Abstract Abstract NNP cord-005453-4057qib7 10910 12 already already RB cord-005453-4057qib7 10910 13 published publish VBN cord-005453-4057qib7 10910 14 . . . cord-005453-4057qib7 10911 1 At at IN cord-005453-4057qib7 10911 2 - - HYPH cord-005453-4057qib7 10911 3 home home NN cord-005453-4057qib7 10911 4 autologous autologous JJ cord-005453-4057qib7 10911 5 stem stem NN cord-005453-4057qib7 10911 6 cell cell NN cord-005453-4057qib7 10911 7 transplantation transplantation NN cord-005453-4057qib7 10911 8 in in IN cord-005453-4057qib7 10911 9 lymphoma lymphoma NN cord-005453-4057qib7 10911 10 patients patient NNS cord-005453-4057qib7 10911 11 : : : cord-005453-4057qib7 10911 12 Clinical clinical JJ cord-005453-4057qib7 10911 13 impact impact NN cord-005453-4057qib7 10911 14 of of IN cord-005453-4057qib7 10911 15 non non JJ cord-005453-4057qib7 10911 16 - - JJ cord-005453-4057qib7 10911 17 G g JJ cord-005453-4057qib7 10911 18 - - HYPH cord-005453-4057qib7 10911 19 CSF CSF NNP cord-005453-4057qib7 10911 20 administration administration NN cord-005453-4057qib7 10911 21 post post NN cord-005453-4057qib7 10911 22 - - NN cord-005453-4057qib7 10911 23 transplant transplant NN cord-005453-4057qib7 10911 24 Background background NN cord-005453-4057qib7 10911 25 : : : cord-005453-4057qib7 10912 1 Severe severe JJ cord-005453-4057qib7 10912 2 neutropenia neutropenia NN cord-005453-4057qib7 10912 3 remains remain VBZ cord-005453-4057qib7 10912 4 the the DT cord-005453-4057qib7 10912 5 main main JJ cord-005453-4057qib7 10912 6 cause cause NN cord-005453-4057qib7 10912 7 of of IN cord-005453-4057qib7 10912 8 morbidity morbidity NN cord-005453-4057qib7 10912 9 and and CC cord-005453-4057qib7 10912 10 mortality mortality NN cord-005453-4057qib7 10912 11 after after IN cord-005453-4057qib7 10912 12 autologous autologous JJ cord-005453-4057qib7 10912 13 stem stem NN cord-005453-4057qib7 10912 14 cell cell NN cord-005453-4057qib7 10912 15 transplantation transplantation NN cord-005453-4057qib7 10912 16 ( ( -LRB- cord-005453-4057qib7 10912 17 ASCT ASCT NNP cord-005453-4057qib7 10912 18 ) ) -RRB- cord-005453-4057qib7 10912 19 . . . cord-005453-4057qib7 10913 1 G G NNP cord-005453-4057qib7 10913 2 - - HYPH cord-005453-4057qib7 10913 3 CSF CSF NNP cord-005453-4057qib7 10913 4 administration administration NN cord-005453-4057qib7 10913 5 after after IN cord-005453-4057qib7 10913 6 ASCT ASCT NNP cord-005453-4057qib7 10913 7 is be VBZ cord-005453-4057qib7 10913 8 a a DT cord-005453-4057qib7 10913 9 common common JJ cord-005453-4057qib7 10913 10 practice practice NN cord-005453-4057qib7 10913 11 , , , cord-005453-4057qib7 10913 12 performed perform VBN cord-005453-4057qib7 10913 13 to to TO cord-005453-4057qib7 10913 14 reduce reduce VB cord-005453-4057qib7 10913 15 the the DT cord-005453-4057qib7 10913 16 duration duration NN cord-005453-4057qib7 10913 17 of of IN cord-005453-4057qib7 10913 18 neutropenia neutropenia NN cord-005453-4057qib7 10913 19 and and CC cord-005453-4057qib7 10913 20 its -PRON- PRP$ cord-005453-4057qib7 10913 21 complications complication NNS cord-005453-4057qib7 10913 22 . . . cord-005453-4057qib7 10914 1 In in IN cord-005453-4057qib7 10914 2 a a DT cord-005453-4057qib7 10914 3 previous previous JJ cord-005453-4057qib7 10914 4 work work NN cord-005453-4057qib7 10914 5 in in IN cord-005453-4057qib7 10914 6 patients patient NNS cord-005453-4057qib7 10914 7 with with IN cord-005453-4057qib7 10914 8 multiple multiple JJ cord-005453-4057qib7 10914 9 myeloma myeloma NN cord-005453-4057qib7 10914 10 managed manage VBN cord-005453-4057qib7 10914 11 at at IN cord-005453-4057qib7 10914 12 home home NN cord-005453-4057qib7 10914 13 after after IN cord-005453-4057qib7 10914 14 ASCT ASCT NNP cord-005453-4057qib7 10914 15 , , , cord-005453-4057qib7 10914 16 we -PRON- PRP cord-005453-4057qib7 10914 17 did do VBD cord-005453-4057qib7 10914 18 not not RB cord-005453-4057qib7 10914 19 observe observe VB cord-005453-4057qib7 10914 20 a a DT cord-005453-4057qib7 10914 21 deleterious deleterious JJ cord-005453-4057qib7 10914 22 clinical clinical JJ cord-005453-4057qib7 10914 23 impact impact NN cord-005453-4057qib7 10914 24 in in IN cord-005453-4057qib7 10914 25 those those DT cord-005453-4057qib7 10914 26 patients patient NNS cord-005453-4057qib7 10914 27 that that WDT cord-005453-4057qib7 10914 28 did do VBD cord-005453-4057qib7 10914 29 not not RB cord-005453-4057qib7 10914 30 receive receive VB cord-005453-4057qib7 10914 31 G G NNP cord-005453-4057qib7 10914 32 - - HYPH cord-005453-4057qib7 10914 33 CSF csf NN cord-005453-4057qib7 10914 34 post post NN cord-005453-4057qib7 10914 35 - - NN cord-005453-4057qib7 10914 36 transplant transplant NN cord-005453-4057qib7 10914 37 ( ( -LRB- cord-005453-4057qib7 10914 38 Martinez Martinez NNP cord-005453-4057qib7 10914 39 - - HYPH cord-005453-4057qib7 10914 40 Cibrian Cibrian NNP cord-005453-4057qib7 10914 41 N. N. NNP cord-005453-4057qib7 10914 42 et et NNP cord-005453-4057qib7 10914 43 al al NNP cord-005453-4057qib7 10914 44 , , , cord-005453-4057qib7 10914 45 BMT BMT NNP cord-005453-4057qib7 10914 46 2016 2016 CD cord-005453-4057qib7 10914 47 ) ) -RRB- cord-005453-4057qib7 10914 48 . . . cord-005453-4057qib7 10915 1 Despite despite IN cord-005453-4057qib7 10915 2 the the DT cord-005453-4057qib7 10915 3 fact fact NN cord-005453-4057qib7 10915 4 that that IN cord-005453-4057qib7 10915 5 lymphoma lymphoma NN cord-005453-4057qib7 10915 6 patients patient NNS cord-005453-4057qib7 10915 7 receive receive VBP cord-005453-4057qib7 10915 8 a a DT cord-005453-4057qib7 10915 9 more more RBR cord-005453-4057qib7 10915 10 intensive intensive JJ cord-005453-4057qib7 10915 11 conditioning conditioning NN cord-005453-4057qib7 10915 12 regimen regimen NN cord-005453-4057qib7 10915 13 that that IN cord-005453-4057qib7 10915 14 multiple multiple JJ cord-005453-4057qib7 10915 15 myeloma myeloma NN cord-005453-4057qib7 10915 16 patients patient NNS cord-005453-4057qib7 10915 17 , , , cord-005453-4057qib7 10915 18 we -PRON- PRP cord-005453-4057qib7 10915 19 hypothesized hypothesize VBD cord-005453-4057qib7 10915 20 that that IN cord-005453-4057qib7 10915 21 the the DT cord-005453-4057qib7 10915 22 use use NN cord-005453-4057qib7 10915 23 of of IN cord-005453-4057qib7 10915 24 G G NNP cord-005453-4057qib7 10915 25 - - HYPH cord-005453-4057qib7 10915 26 CSF CSF NNP cord-005453-4057qib7 10915 27 in in IN cord-005453-4057qib7 10915 28 lymphoma lymphoma NN cord-005453-4057qib7 10915 29 patients patient NNS cord-005453-4057qib7 10915 30 managed manage VBD cord-005453-4057qib7 10915 31 at at IN cord-005453-4057qib7 10915 32 home home NN cord-005453-4057qib7 10915 33 during during IN cord-005453-4057qib7 10915 34 the the DT cord-005453-4057qib7 10915 35 aplasia aplasia JJ cord-005453-4057qib7 10915 36 phase phase NN cord-005453-4057qib7 10915 37 of of IN cord-005453-4057qib7 10915 38 ASCT ASCT NNP cord-005453-4057qib7 10915 39 does do VBZ cord-005453-4057qib7 10915 40 not not RB cord-005453-4057qib7 10915 41 provide provide VB cord-005453-4057qib7 10915 42 a a DT cord-005453-4057qib7 10915 43 significant significant JJ cord-005453-4057qib7 10915 44 clinical clinical JJ cord-005453-4057qib7 10915 45 benefit benefit NN cord-005453-4057qib7 10915 46 . . . cord-005453-4057qib7 10916 1 Methods method NNS cord-005453-4057qib7 10916 2 : : : cord-005453-4057qib7 10917 1 93 93 CD cord-005453-4057qib7 10917 2 lymphoma lymphoma NN cord-005453-4057qib7 10917 3 patients patient NNS cord-005453-4057qib7 10917 4 were be VBD cord-005453-4057qib7 10917 5 managed manage VBN cord-005453-4057qib7 10917 6 at at IN cord-005453-4057qib7 10917 7 - - HYPH cord-005453-4057qib7 10917 8 home home NN cord-005453-4057qib7 10917 9 since since IN cord-005453-4057qib7 10917 10 day day NN cord-005453-4057qib7 10917 11 +1 +1 NNS cord-005453-4057qib7 10917 12 of of IN cord-005453-4057qib7 10917 13 ASCT ASCT NNP cord-005453-4057qib7 10917 14 . . . cord-005453-4057qib7 10918 1 Between between IN cord-005453-4057qib7 10918 2 February February NNP cord-005453-4057qib7 10918 3 2010 2010 CD cord-005453-4057qib7 10918 4 and and CC cord-005453-4057qib7 10918 5 July July NNP cord-005453-4057qib7 10918 6 2016 2016 CD cord-005453-4057qib7 10918 7 , , , cord-005453-4057qib7 10918 8 68 68 CD cord-005453-4057qib7 10918 9 patients patient NNS cord-005453-4057qib7 10918 10 received receive VBN cord-005453-4057qib7 10918 11 at at IN cord-005453-4057qib7 10918 12 - - HYPH cord-005453-4057qib7 10918 13 home home NN cord-005453-4057qib7 10918 14 G G NNP cord-005453-4057qib7 10918 15 - - HYPH cord-005453-4057qib7 10918 16 CSF CSF NNP cord-005453-4057qib7 10918 17 5 5 CD cord-005453-4057qib7 10918 18 μg μg NNP cord-005453-4057qib7 10918 19 / / SYM cord-005453-4057qib7 10918 20 kg kg NN cord-005453-4057qib7 10918 21 per per IN cord-005453-4057qib7 10918 22 day day NN cord-005453-4057qib7 10918 23 since since IN cord-005453-4057qib7 10918 24 day day NN cord-005453-4057qib7 10918 25 +7 +7 . cord-005453-4057qib7 10918 26 until until IN cord-005453-4057qib7 10918 27 their -PRON- PRP$ cord-005453-4057qib7 10918 28 ANC ANC NNP cord-005453-4057qib7 10918 29 reached reach VBD cord-005453-4057qib7 10918 30 1x10 1x10 CD cord-005453-4057qib7 10918 31 9 9 CD cord-005453-4057qib7 10918 32 /L /L . cord-005453-4057qib7 10918 33 ( ( -LRB- cord-005453-4057qib7 10918 34 G G NNP cord-005453-4057qib7 10918 35 - - HYPH cord-005453-4057qib7 10918 36 CSF CSF NNP cord-005453-4057qib7 10918 37 group group NN cord-005453-4057qib7 10918 38 ) ) -RRB- cord-005453-4057qib7 10918 39 and and CC cord-005453-4057qib7 10918 40 , , , cord-005453-4057qib7 10918 41 since since IN cord-005453-4057qib7 10918 42 August August NNP cord-005453-4057qib7 10918 43 2016 2016 CD cord-005453-4057qib7 10918 44 , , , cord-005453-4057qib7 10918 45 25 25 CD cord-005453-4057qib7 10918 46 patients patient NNS cord-005453-4057qib7 10918 47 did do VBD cord-005453-4057qib7 10918 48 not not RB cord-005453-4057qib7 10918 49 receive receive VB cord-005453-4057qib7 10918 50 G G NNP cord-005453-4057qib7 10918 51 - - HYPH cord-005453-4057qib7 10918 52 CSF CSF NNP cord-005453-4057qib7 10918 53 ( ( -LRB- cord-005453-4057qib7 10918 54 non non JJ cord-005453-4057qib7 10918 55 - - JJ cord-005453-4057qib7 10918 56 G g JJ cord-005453-4057qib7 10918 57 - - HYPH cord-005453-4057qib7 10918 58 CSF CSF NNP cord-005453-4057qib7 10918 59 group group NN cord-005453-4057qib7 10918 60 ) ) -RRB- cord-005453-4057qib7 10918 61 . . . cord-005453-4057qib7 10919 1 All all DT cord-005453-4057qib7 10919 2 patients patient NNS cord-005453-4057qib7 10919 3 were be VBD cord-005453-4057qib7 10919 4 conditioned condition VBN cord-005453-4057qib7 10919 5 with with IN cord-005453-4057qib7 10919 6 BEAM BEAM NNP cord-005453-4057qib7 10919 7 and and CC cord-005453-4057qib7 10919 8 received receive VBD cord-005453-4057qib7 10919 9 prophylaxis prophylaxis NN cord-005453-4057qib7 10919 10 with with IN cord-005453-4057qib7 10919 11 a a DT cord-005453-4057qib7 10919 12 quinolone quinolone NN cord-005453-4057qib7 10919 13 , , , cord-005453-4057qib7 10919 14 fluconazole fluconazole NN cord-005453-4057qib7 10919 15 , , , cord-005453-4057qib7 10919 16 aerosolized aerosolize VBN cord-005453-4057qib7 10919 17 pentamidine pentamidine NN cord-005453-4057qib7 10919 18 and and CC cord-005453-4057qib7 10919 19 low low JJ cord-005453-4057qib7 10919 20 - - HYPH cord-005453-4057qib7 10919 21 dose dose NN cord-005453-4057qib7 10919 22 acyclovir acyclovir NN cord-005453-4057qib7 10919 23 ( ( -LRB- cord-005453-4057qib7 10919 24 HVS+ HVS+ NNP cord-005453-4057qib7 10919 25 ) ) -RRB- cord-005453-4057qib7 10919 26 . . . cord-005453-4057qib7 10920 1 In in IN cord-005453-4057qib7 10920 2 all all DT cord-005453-4057qib7 10920 3 cases case NNS cord-005453-4057qib7 10920 4 we -PRON- PRP cord-005453-4057qib7 10920 5 added add VBD cord-005453-4057qib7 10920 6 primary primary JJ cord-005453-4057qib7 10920 7 prophylaxis prophylaxis NN cord-005453-4057qib7 10920 8 with with IN cord-005453-4057qib7 10920 9 piperacillin piperacillin NNP cord-005453-4057qib7 10920 10 - - HYPH cord-005453-4057qib7 10920 11 tazobactam tazobactam NNS cord-005453-4057qib7 10920 12 4.5 4.5 CD cord-005453-4057qib7 10920 13 g/8h g/8h NNP cord-005453-4057qib7 10920 14 i.v i.v NNP cord-005453-4057qib7 10920 15 . . NNP cord-005453-4057qib7 10920 16 , , , cord-005453-4057qib7 10920 17 using use VBG cord-005453-4057qib7 10920 18 a a DT cord-005453-4057qib7 10920 19 portable portable JJ cord-005453-4057qib7 10920 20 intermittent intermittent JJ cord-005453-4057qib7 10920 21 infusion infusion NN cord-005453-4057qib7 10920 22 pump pump NN cord-005453-4057qib7 10920 23 ( ( -LRB- cord-005453-4057qib7 10920 24 IIP IIP NNP cord-005453-4057qib7 10920 25 ) ) -RRB- cord-005453-4057qib7 10920 26 , , , cord-005453-4057qib7 10920 27 from from IN cord-005453-4057qib7 10920 28 an an DT cord-005453-4057qib7 10920 29 absolute absolute JJ cord-005453-4057qib7 10920 30 neutrophil neutrophil NN cord-005453-4057qib7 10920 31 count count NN cord-005453-4057qib7 10920 32 ( ( -LRB- cord-005453-4057qib7 10920 33 ANC ANC NNP cord-005453-4057qib7 10920 34 ) ) -RRB- cord-005453-4057qib7 10920 35 < < XX cord-005453-4057qib7 10920 36 0.5x10 0.5x10 CD cord-005453-4057qib7 10920 37 9 9 CD cord-005453-4057qib7 10920 38 /L /L . cord-005453-4057qib7 10920 39 until until IN cord-005453-4057qib7 10920 40 the the DT cord-005453-4057qib7 10920 41 first first JJ cord-005453-4057qib7 10920 42 day day NN cord-005453-4057qib7 10920 43 of of IN cord-005453-4057qib7 10920 44 fever fever NN cord-005453-4057qib7 10920 45 or or CC cord-005453-4057qib7 10920 46 until until IN cord-005453-4057qib7 10920 47 attaining attain VBG cord-005453-4057qib7 10920 48 an an DT cord-005453-4057qib7 10920 49 ANC ANC NNP cord-005453-4057qib7 10920 50 of of IN cord-005453-4057qib7 10920 51 1x10 1x10 CD cord-005453-4057qib7 10920 52 9 9 CD cord-005453-4057qib7 10921 1 /L. /L. . cord-005453-4057qib7 10922 1 First first JJ cord-005453-4057qib7 10922 2 - - HYPH cord-005453-4057qib7 10922 3 line line NN cord-005453-4057qib7 10922 4 therapy therapy NN cord-005453-4057qib7 10922 5 at at IN cord-005453-4057qib7 10922 6 home home NN cord-005453-4057qib7 10922 7 of of IN cord-005453-4057qib7 10922 8 neutropenic neutropenic JJ cord-005453-4057qib7 10922 9 fever fever NN cord-005453-4057qib7 10922 10 ( ( -LRB- cord-005453-4057qib7 10922 11 NF NF NNP cord-005453-4057qib7 10922 12 ) ) -RRB- cord-005453-4057qib7 10922 13 was be VBD cord-005453-4057qib7 10922 14 refrigerated refrigerate VBN cord-005453-4057qib7 10922 15 meropenem meropenem NNP cord-005453-4057qib7 10922 16 1 1 CD cord-005453-4057qib7 10922 17 g/8h g/8h NNP cord-005453-4057qib7 10922 18 i.v i.v NNP cord-005453-4057qib7 10922 19 using use VBG cord-005453-4057qib7 10922 20 a a DT cord-005453-4057qib7 10922 21 portable portable JJ cord-005453-4057qib7 10922 22 IIP IIP NNP cord-005453-4057qib7 10922 23 . . . cord-005453-4057qib7 10923 1 Fever fever NN cord-005453-4057qib7 10923 2 was be VBD cord-005453-4057qib7 10923 3 an an DT cord-005453-4057qib7 10923 4 indication indication NN cord-005453-4057qib7 10923 5 of of IN cord-005453-4057qib7 10923 6 immediate immediate JJ cord-005453-4057qib7 10923 7 visit visit NN cord-005453-4057qib7 10923 8 to to IN cord-005453-4057qib7 10923 9 the the DT cord-005453-4057qib7 10923 10 hospital hospital NN cord-005453-4057qib7 10923 11 , , , cord-005453-4057qib7 10923 12 and and CC cord-005453-4057qib7 10923 13 those those DT cord-005453-4057qib7 10923 14 patients patient NNS cord-005453-4057qib7 10923 15 presenting present VBG cord-005453-4057qib7 10923 16 with with IN cord-005453-4057qib7 10923 17 focal focal JJ cord-005453-4057qib7 10923 18 infection infection NN cord-005453-4057qib7 10923 19 or or CC cord-005453-4057qib7 10923 20 signs sign NNS cord-005453-4057qib7 10923 21 of of IN cord-005453-4057qib7 10923 22 severe severe JJ cord-005453-4057qib7 10923 23 sepsis sepsis NN cord-005453-4057qib7 10923 24 were be VBD cord-005453-4057qib7 10923 25 admitted admit VBN cord-005453-4057qib7 10923 26 . . . cord-005453-4057qib7 10924 1 Other other JJ cord-005453-4057qib7 10924 2 indications indication NNS cord-005453-4057qib7 10924 3 for for IN cord-005453-4057qib7 10924 4 readmission readmission NN cord-005453-4057qib7 10924 5 were be VBD cord-005453-4057qib7 10924 6 : : : cord-005453-4057qib7 10924 7 willingness willingness NN cord-005453-4057qib7 10924 8 of of IN cord-005453-4057qib7 10924 9 the the DT cord-005453-4057qib7 10924 10 patient patient NN cord-005453-4057qib7 10924 11 or or CC cord-005453-4057qib7 10924 12 caregiver caregiver NN cord-005453-4057qib7 10924 13 ; ; , cord-005453-4057qib7 10924 14 uncontrolled uncontrolled JJ cord-005453-4057qib7 10924 15 nausea nausea NN cord-005453-4057qib7 10924 16 , , , cord-005453-4057qib7 10924 17 vomiting vomiting NN cord-005453-4057qib7 10924 18 or or CC cord-005453-4057qib7 10924 19 diarrhea diarrhea NN cord-005453-4057qib7 10924 20 and and CC cord-005453-4057qib7 10924 21 mucositis mucositis NNP cord-005453-4057qib7 10924 22 requiring require VBG cord-005453-4057qib7 10924 23 total total JJ cord-005453-4057qib7 10924 24 parenteral parenteral JJ cord-005453-4057qib7 10924 25 nutrition nutrition NN cord-005453-4057qib7 10924 26 or or CC cord-005453-4057qib7 10924 27 i.v i.v NNP cord-005453-4057qib7 10924 28 . . NNP cord-005453-4057qib7 10924 29 morphics morphic NNS cord-005453-4057qib7 10924 30 . . . cord-005453-4057qib7 10925 1 Results result NNS cord-005453-4057qib7 10925 2 : : : cord-005453-4057qib7 10926 1 The the DT cord-005453-4057qib7 10926 2 main main JJ cord-005453-4057qib7 10926 3 characteristics characteristic NNS cord-005453-4057qib7 10926 4 of of IN cord-005453-4057qib7 10926 5 the the DT cord-005453-4057qib7 10926 6 patients patient NNS cord-005453-4057qib7 10926 7 are be VBP cord-005453-4057qib7 10926 8 shown show VBN cord-005453-4057qib7 10926 9 in in IN cord-005453-4057qib7 10926 10 table table NN cord-005453-4057qib7 10926 11 1 1 CD cord-005453-4057qib7 10926 12 . . . cord-005453-4057qib7 10927 1 There there EX cord-005453-4057qib7 10927 2 were be VBD cord-005453-4057qib7 10927 3 no no DT cord-005453-4057qib7 10927 4 differences difference NNS cord-005453-4057qib7 10927 5 between between IN cord-005453-4057qib7 10927 6 groups group NNS cord-005453-4057qib7 10927 7 with with IN cord-005453-4057qib7 10927 8 respect respect NN cord-005453-4057qib7 10927 9 to to IN cord-005453-4057qib7 10927 10 gender gender NN cord-005453-4057qib7 10927 11 , , , cord-005453-4057qib7 10927 12 diagnosis diagnosis NN cord-005453-4057qib7 10927 13 , , , cord-005453-4057qib7 10927 14 stage stage NN cord-005453-4057qib7 10927 15 of of IN cord-005453-4057qib7 10927 16 disease disease NN cord-005453-4057qib7 10927 17 , , , cord-005453-4057qib7 10927 18 comorbidity comorbidity NN cord-005453-4057qib7 10927 19 index index NN cord-005453-4057qib7 10927 20 ( ( -LRB- cord-005453-4057qib7 10927 21 HCT HCT NNP cord-005453-4057qib7 10927 22 - - HYPH cord-005453-4057qib7 10927 23 CI CI NNP cord-005453-4057qib7 10927 24 ) ) -RRB- cord-005453-4057qib7 10927 25 , , , cord-005453-4057qib7 10927 26 source source NN cord-005453-4057qib7 10927 27 of of IN cord-005453-4057qib7 10927 28 stem stem NN cord-005453-4057qib7 10927 29 cells cell NNS cord-005453-4057qib7 10927 30 ( ( -LRB- cord-005453-4057qib7 10927 31 peripheral peripheral JJ cord-005453-4057qib7 10927 32 blood blood NN cord-005453-4057qib7 10927 33 ) ) -RRB- cord-005453-4057qib7 10927 34 and and CC cord-005453-4057qib7 10927 35 CD34 CD34 NNP cord-005453-4057qib7 10927 36 + + CC cord-005453-4057qib7 10927 37 cell cell NN cord-005453-4057qib7 10927 38 dose dose NN cord-005453-4057qib7 10927 39 infused infuse VBN cord-005453-4057qib7 10927 40 . . . cord-005453-4057qib7 10928 1 The the DT cord-005453-4057qib7 10928 2 median median NN cord-005453-4057qib7 10928 3 ( ( -LRB- cord-005453-4057qib7 10928 4 range range NN cord-005453-4057qib7 10928 5 ) ) -RRB- cord-005453-4057qib7 10928 6 age age NN cord-005453-4057qib7 10928 7 ( ( -LRB- cord-005453-4057qib7 10928 8 years year NNS cord-005453-4057qib7 10928 9 ) ) -RRB- cord-005453-4057qib7 10928 10 was be VBD cord-005453-4057qib7 10928 11 44 44 CD cord-005453-4057qib7 10928 12 ( ( -LRB- cord-005453-4057qib7 10928 13 19 19 CD cord-005453-4057qib7 10928 14 - - SYM cord-005453-4057qib7 10928 15 71 71 CD cord-005453-4057qib7 10928 16 ) ) -RRB- cord-005453-4057qib7 10928 17 in in IN cord-005453-4057qib7 10928 18 G G NNP cord-005453-4057qib7 10928 19 - - HYPH cord-005453-4057qib7 10928 20 CSF CSF NNP cord-005453-4057qib7 10928 21 group group NN cord-005453-4057qib7 10928 22 and and CC cord-005453-4057qib7 10928 23 52 52 CD cord-005453-4057qib7 10928 24 in in IN cord-005453-4057qib7 10928 25 non non JJ cord-005453-4057qib7 10928 26 - - JJ cord-005453-4057qib7 10928 27 G g JJ cord-005453-4057qib7 10928 28 - - HYPH cord-005453-4057qib7 10928 29 CSF csf NN cord-005453-4057qib7 10928 30 group group NN cord-005453-4057qib7 10928 31 ( ( -LRB- cord-005453-4057qib7 10928 32 p=0.03 p=0.03 NN cord-005453-4057qib7 10928 33 ) ) -RRB- cord-005453-4057qib7 10928 34 . . . cord-005453-4057qib7 10929 1 Duration duration NN cord-005453-4057qib7 10929 2 of of IN cord-005453-4057qib7 10929 3 neutropenia neutropenia NN cord-005453-4057qib7 10929 4 less less JJR cord-005453-4057qib7 10929 5 than than IN cord-005453-4057qib7 10929 6 0.5 0.5 CD cord-005453-4057qib7 10929 7 x10 x10 CD cord-005453-4057qib7 10929 8 9 9 CD cord-005453-4057qib7 10929 9 /L /L , cord-005453-4057qib7 10929 10 was be VBD cord-005453-4057qib7 10929 11 significantly significantly RB cord-005453-4057qib7 10929 12 longer long JJR cord-005453-4057qib7 10929 13 in in IN cord-005453-4057qib7 10929 14 non non JJ cord-005453-4057qib7 10929 15 - - JJ cord-005453-4057qib7 10929 16 G g JJ cord-005453-4057qib7 10929 17 - - HYPH cord-005453-4057qib7 10929 18 CSF CSF NNP cord-005453-4057qib7 10929 19 group group NN cord-005453-4057qib7 10929 20 , , , cord-005453-4057qib7 10929 21 with with IN cord-005453-4057qib7 10929 22 a a DT cord-005453-4057qib7 10929 23 median median NN cord-005453-4057qib7 10929 24 of of IN cord-005453-4057qib7 10929 25 11 11 CD cord-005453-4057qib7 10929 26 days day NNS cord-005453-4057qib7 10929 27 ( ( -LRB- cord-005453-4057qib7 10929 28 range range VBP cord-005453-4057qib7 10929 29 6 6 CD cord-005453-4057qib7 10929 30 - - SYM cord-005453-4057qib7 10929 31 19 19 CD cord-005453-4057qib7 10929 32 ) ) -RRB- cord-005453-4057qib7 10929 33 , , , cord-005453-4057qib7 10929 34 compared compare VBN cord-005453-4057qib7 10929 35 with with IN cord-005453-4057qib7 10929 36 8 8 CD cord-005453-4057qib7 10929 37 ( ( -LRB- cord-005453-4057qib7 10929 38 range range NNP cord-005453-4057qib7 10929 39 6 6 CD cord-005453-4057qib7 10929 40 - - SYM cord-005453-4057qib7 10929 41 17 17 CD cord-005453-4057qib7 10929 42 ) ) -RRB- cord-005453-4057qib7 10929 43 in in IN cord-005453-4057qib7 10929 44 G G NNP cord-005453-4057qib7 10929 45 - - HYPH cord-005453-4057qib7 10929 46 CSF CSF NNP cord-005453-4057qib7 10929 47 group group NN cord-005453-4057qib7 10929 48 ( ( -LRB- cord-005453-4057qib7 10929 49 p p NN cord-005453-4057qib7 10929 50 < < XX cord-005453-4057qib7 10929 51 0.0001 0.0001 CD cord-005453-4057qib7 10929 52 ) ) -RRB- cord-005453-4057qib7 10929 53 . . . cord-005453-4057qib7 10930 1 Severe severe JJ cord-005453-4057qib7 10930 2 neutropenia neutropenia NN cord-005453-4057qib7 10930 3 , , , cord-005453-4057qib7 10930 4 less less JJR cord-005453-4057qib7 10930 5 than than IN cord-005453-4057qib7 10930 6 0.1x10 0.1x10 CD cord-005453-4057qib7 10930 7 9 9 CD cord-005453-4057qib7 10930 8 /L /L , cord-005453-4057qib7 10930 9 , , , cord-005453-4057qib7 10930 10 was be VBD cord-005453-4057qib7 10930 11 also also RB cord-005453-4057qib7 10930 12 longer long JJR cord-005453-4057qib7 10930 13 in in IN cord-005453-4057qib7 10930 14 the the DT cord-005453-4057qib7 10930 15 non non JJ cord-005453-4057qib7 10930 16 - - JJ cord-005453-4057qib7 10930 17 G g JJ cord-005453-4057qib7 10930 18 - - HYPH cord-005453-4057qib7 10930 19 CSF csf NN cord-005453-4057qib7 10930 20 group group NN cord-005453-4057qib7 10930 21 ( ( -LRB- cord-005453-4057qib7 10930 22 8 8 CD cord-005453-4057qib7 10930 23 days day NNS cord-005453-4057qib7 10930 24 ( ( -LRB- cord-005453-4057qib7 10930 25 4 4 CD cord-005453-4057qib7 10930 26 - - SYM cord-005453-4057qib7 10930 27 11 11 CD cord-005453-4057qib7 10930 28 ) ) -RRB- cord-005453-4057qib7 10930 29 vs. vs. FW cord-005453-4057qib7 10930 30 7 7 CD cord-005453-4057qib7 10930 31 ( ( -LRB- cord-005453-4057qib7 10930 32 5 5 CD cord-005453-4057qib7 10930 33 - - SYM cord-005453-4057qib7 10930 34 13 13 CD cord-005453-4057qib7 10930 35 ) ) -RRB- cord-005453-4057qib7 10930 36 ; ; : cord-005453-4057qib7 10930 37 p=0.014 p=0.014 NNS cord-005453-4057qib7 10930 38 ) ) -RRB- cord-005453-4057qib7 10930 39 . . . cord-005453-4057qib7 10931 1 No no DT cord-005453-4057qib7 10931 2 differences difference NNS cord-005453-4057qib7 10931 3 were be VBD cord-005453-4057qib7 10931 4 observed observe VBN cord-005453-4057qib7 10931 5 in in IN cord-005453-4057qib7 10931 6 the the DT cord-005453-4057qib7 10931 7 time time NN cord-005453-4057qib7 10931 8 to to IN cord-005453-4057qib7 10931 9 platelet platelet NN cord-005453-4057qib7 10931 10 engraftment engraftment NN cord-005453-4057qib7 10931 11 . . . cord-005453-4057qib7 10932 1 G G NNP cord-005453-4057qib7 10932 2 - - HYPH cord-005453-4057qib7 10932 3 CSF csf NN cord-005453-4057qib7 10932 4 post post JJ cord-005453-4057qib7 10932 5 - - JJ cord-005453-4057qib7 10932 6 transplant transplant JJ cord-005453-4057qib7 10932 7 avoidance avoidance NN cord-005453-4057qib7 10932 8 did do VBD cord-005453-4057qib7 10932 9 not not RB cord-005453-4057qib7 10932 10 influence influence VB cord-005453-4057qib7 10932 11 the the DT cord-005453-4057qib7 10932 12 incidence incidence NN cord-005453-4057qib7 10932 13 of of IN cord-005453-4057qib7 10932 14 neutropenic neutropenic JJ cord-005453-4057qib7 10932 15 fever fever NN cord-005453-4057qib7 10932 16 , , , cord-005453-4057qib7 10932 17 the the DT cord-005453-4057qib7 10932 18 first first JJ cord-005453-4057qib7 10932 19 day day NN cord-005453-4057qib7 10932 20 and and CC cord-005453-4057qib7 10932 21 duration duration NN cord-005453-4057qib7 10932 22 of of IN cord-005453-4057qib7 10932 23 fever fever NN cord-005453-4057qib7 10932 24 , , , cord-005453-4057qib7 10932 25 the the DT cord-005453-4057qib7 10932 26 incidence incidence NN cord-005453-4057qib7 10932 27 and and CC cord-005453-4057qib7 10932 28 severity severity NN cord-005453-4057qib7 10932 29 of of IN cord-005453-4057qib7 10932 30 oral oral JJ cord-005453-4057qib7 10932 31 mucositis mucositis NN cord-005453-4057qib7 10932 32 , , , cord-005453-4057qib7 10932 33 bacterial bacterial JJ cord-005453-4057qib7 10932 34 infections infection NNS cord-005453-4057qib7 10932 35 documented document VBN cord-005453-4057qib7 10932 36 and and CC cord-005453-4057qib7 10932 37 number number NN cord-005453-4057qib7 10932 38 of of IN cord-005453-4057qib7 10932 39 readmissions readmission NNS cord-005453-4057qib7 10932 40 . . . cord-005453-4057qib7 10933 1 The the DT cord-005453-4057qib7 10933 2 median median JJ cord-005453-4057qib7 10933 3 duration duration NN cord-005453-4057qib7 10933 4 of of IN cord-005453-4057qib7 10933 5 the the DT cord-005453-4057qib7 10933 6 whole whole JJ cord-005453-4057qib7 10933 7 procedure procedure NN cord-005453-4057qib7 10933 8 at at IN cord-005453-4057qib7 10933 9 - - HYPH cord-005453-4057qib7 10933 10 home home NN cord-005453-4057qib7 10933 11 was be VBD cord-005453-4057qib7 10933 12 1 1 CD cord-005453-4057qib7 10933 13 day day NN cord-005453-4057qib7 10933 14 shorter short JJR cord-005453-4057qib7 10933 15 in in IN cord-005453-4057qib7 10933 16 the the DT cord-005453-4057qib7 10933 17 G G NNP cord-005453-4057qib7 10933 18 - - HYPH cord-005453-4057qib7 10933 19 CSF CSF NNP cord-005453-4057qib7 10933 20 group group NN cord-005453-4057qib7 10933 21 ( ( -LRB- cord-005453-4057qib7 10933 22 14 14 CD cord-005453-4057qib7 10933 23 vs. vs. NN cord-005453-4057qib7 10933 24 15 15 CD cord-005453-4057qib7 10933 25 days day NNS cord-005453-4057qib7 10933 26 ; ; : cord-005453-4057qib7 10933 27 p=0.12 p=0.12 NN cord-005453-4057qib7 10933 28 ) ) -RRB- cord-005453-4057qib7 10933 29 . . . cord-005453-4057qib7 10934 1 Conclusions conclusion NNS cord-005453-4057qib7 10934 2 : : : cord-005453-4057qib7 10935 1 The the DT cord-005453-4057qib7 10935 2 policy policy NN cord-005453-4057qib7 10935 3 of of IN cord-005453-4057qib7 10935 4 not not RB cord-005453-4057qib7 10935 5 administering administer VBG cord-005453-4057qib7 10935 6 G G NNP cord-005453-4057qib7 10935 7 - - HYPH cord-005453-4057qib7 10935 8 CSF csf NN cord-005453-4057qib7 10935 9 post post NN cord-005453-4057qib7 10935 10 - - JJ cord-005453-4057qib7 10935 11 ASCT asct NN cord-005453-4057qib7 10935 12 in in IN cord-005453-4057qib7 10935 13 our -PRON- PRP$ cord-005453-4057qib7 10935 14 home home NN cord-005453-4057qib7 10935 15 - - HYPH cord-005453-4057qib7 10935 16 based base VBN cord-005453-4057qib7 10935 17 program program NN cord-005453-4057qib7 10935 18 for for IN cord-005453-4057qib7 10935 19 lymphoma lymphoma NN cord-005453-4057qib7 10935 20 patients patient NNS cord-005453-4057qib7 10935 21 , , , cord-005453-4057qib7 10935 22 that that WDT cord-005453-4057qib7 10935 23 include include VBP cord-005453-4057qib7 10935 24 intensive intensive JJ cord-005453-4057qib7 10935 25 bacterial bacterial JJ cord-005453-4057qib7 10935 26 prophylaxis prophylaxis NN cord-005453-4057qib7 10935 27 , , , cord-005453-4057qib7 10935 28 did do VBD cord-005453-4057qib7 10935 29 not not RB cord-005453-4057qib7 10935 30 have have VB cord-005453-4057qib7 10935 31 a a DT cord-005453-4057qib7 10935 32 deleterious deleterious JJ cord-005453-4057qib7 10935 33 impact impact NN cord-005453-4057qib7 10935 34 on on IN cord-005453-4057qib7 10935 35 the the DT cord-005453-4057qib7 10935 36 main main JJ cord-005453-4057qib7 10935 37 results result NNS cord-005453-4057qib7 10935 38 reviewed review VBN cord-005453-4057qib7 10935 39 , , , cord-005453-4057qib7 10935 40 which which WDT cord-005453-4057qib7 10935 41 suggests suggest VBZ cord-005453-4057qib7 10935 42 that that IN cord-005453-4057qib7 10935 43 elimination elimination NN cord-005453-4057qib7 10935 44 of of IN cord-005453-4057qib7 10935 45 its -PRON- PRP$ cord-005453-4057qib7 10935 46 use use NN cord-005453-4057qib7 10935 47 can can MD cord-005453-4057qib7 10935 48 be be VB cord-005453-4057qib7 10935 49 achieved achieve VBN cord-005453-4057qib7 10935 50 . . . cord-005453-4057qib7 10936 1 Disclosure disclosure NN cord-005453-4057qib7 10937 1 The the DT cord-005453-4057qib7 10937 2 aim aim NN cord-005453-4057qib7 10937 3 of of IN cord-005453-4057qib7 10937 4 this this DT cord-005453-4057qib7 10937 5 study study NN cord-005453-4057qib7 10937 6 was be VBD cord-005453-4057qib7 10937 7 to to TO cord-005453-4057qib7 10937 8 analyze analyze VB cord-005453-4057qib7 10937 9 the the DT cord-005453-4057qib7 10937 10 Spanish spanish JJ cord-005453-4057qib7 10937 11 experience experience NN cord-005453-4057qib7 10937 12 with with IN cord-005453-4057qib7 10937 13 patients patient NNS cord-005453-4057qib7 10937 14 diagnosed diagnose VBN cord-005453-4057qib7 10937 15 of of IN cord-005453-4057qib7 10937 16 NHL NHL NNP cord-005453-4057qib7 10937 17 who who WP cord-005453-4057qib7 10937 18 received receive VBD cord-005453-4057qib7 10937 19 HaploSCT HaploSCT NNP cord-005453-4057qib7 10937 20 with with IN cord-005453-4057qib7 10937 21 Pt Pt NNP cord-005453-4057qib7 10937 22 - - HYPH cord-005453-4057qib7 10937 23 Cy Cy NNP cord-005453-4057qib7 10937 24 . . . cord-005453-4057qib7 10938 1 Methods method NNS cord-005453-4057qib7 10938 2 : : : cord-005453-4057qib7 10939 1 Sixty sixty CD cord-005453-4057qib7 10939 2 patients patient NNS cord-005453-4057qib7 10939 3 who who WP cord-005453-4057qib7 10939 4 received receive VBD cord-005453-4057qib7 10939 5 HaploSCT HaploSCT NNP cord-005453-4057qib7 10939 6 with with IN cord-005453-4057qib7 10939 7 Pt Pt NNP cord-005453-4057qib7 10939 8 - - HYPH cord-005453-4057qib7 10939 9 CY CY NNP cord-005453-4057qib7 10939 10 in in IN cord-005453-4057qib7 10939 11 17 17 CD cord-005453-4057qib7 10939 12 Spanish spanish JJ cord-005453-4057qib7 10939 13 centers center NNS cord-005453-4057qib7 10939 14 from from IN cord-005453-4057qib7 10939 15 2012 2012 CD cord-005453-4057qib7 10939 16 to to IN cord-005453-4057qib7 10939 17 2016 2016 CD cord-005453-4057qib7 10939 18 were be VBD cord-005453-4057qib7 10939 19 analyzed analyze VBN cord-005453-4057qib7 10939 20 . . . cord-005453-4057qib7 10940 1 Patients patient NNS cord-005453-4057qib7 10940 2 were be VBD cord-005453-4057qib7 10940 3 followed follow VBN cord-005453-4057qib7 10940 4 - - HYPH cord-005453-4057qib7 10940 5 up up NN cord-005453-4057qib7 10940 6 until until IN cord-005453-4057qib7 10940 7 2017 2017 CD cord-005453-4057qib7 10940 8 . . . cord-005453-4057qib7 10941 1 GVHD GVHD NNP cord-005453-4057qib7 10941 2 prophylaxis prophylaxis NN cord-005453-4057qib7 10941 3 consisted consist VBD cord-005453-4057qib7 10941 4 in in IN cord-005453-4057qib7 10941 5 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 10941 6 50 50 CD cord-005453-4057qib7 10941 7 mg mg NNP cord-005453-4057qib7 10941 8 / / SYM cord-005453-4057qib7 10941 9 kg kg NNP cord-005453-4057qib7 10941 10 / / SYM cord-005453-4057qib7 10941 11 d d NN cord-005453-4057qib7 10941 12 on on IN cord-005453-4057qib7 10941 13 days day NNS cord-005453-4057qib7 10941 14 +3 +3 NNP cord-005453-4057qib7 10941 15 and and CC cord-005453-4057qib7 10941 16 +4 +4 NNP cord-005453-4057qib7 10941 17 , , , cord-005453-4057qib7 10941 18 and and CC cord-005453-4057qib7 10941 19 MMF mmf NN cord-005453-4057qib7 10941 20 and and CC cord-005453-4057qib7 10941 21 a a DT cord-005453-4057qib7 10941 22 calcineurin calcineurin JJ cord-005453-4057qib7 10941 23 inhibitor inhibitor NN cord-005453-4057qib7 10941 24 from from IN cord-005453-4057qib7 10941 25 day day NN cord-005453-4057qib7 10941 26 +5 +5 NFP cord-005453-4057qib7 10941 27 . . . cord-005453-4057qib7 10942 1 Results result NNS cord-005453-4057qib7 10942 2 : : : cord-005453-4057qib7 10943 1 Patients patient NNS cord-005453-4057qib7 10943 2 ' ' POS cord-005453-4057qib7 10943 3 characteristics characteristic NNS cord-005453-4057qib7 10943 4 are be VBP cord-005453-4057qib7 10943 5 summarized summarize VBN cord-005453-4057qib7 10943 6 on on IN cord-005453-4057qib7 10943 7 Table Table NNP cord-005453-4057qib7 10943 8 _SP cord-005453-4057qib7 10943 9 1 1 CD cord-005453-4057qib7 10943 10 . . . cord-005453-4057qib7 10944 1 Median median JJ cord-005453-4057qib7 10944 2 age age NN cord-005453-4057qib7 10944 3 of of IN cord-005453-4057qib7 10944 4 patients patient NNS cord-005453-4057qib7 10944 5 was be VBD cord-005453-4057qib7 10944 6 50 50 CD cord-005453-4057qib7 10944 7 , , , cord-005453-4057qib7 10944 8 75 75 CD cord-005453-4057qib7 10944 9 % % NN cord-005453-4057qib7 10944 10 male male NN cord-005453-4057qib7 10944 11 , , , cord-005453-4057qib7 10944 12 and and CC cord-005453-4057qib7 10944 13 diagnosed diagnose VBN cord-005453-4057qib7 10944 14 from from IN cord-005453-4057qib7 10944 15 T T NNP cord-005453-4057qib7 10944 16 cell cell NN cord-005453-4057qib7 10944 17 lymphoma lymphoma NN cord-005453-4057qib7 10944 18 ( ( -LRB- cord-005453-4057qib7 10944 19 37 37 CD cord-005453-4057qib7 10944 20 % % NN cord-005453-4057qib7 10944 21 ) ) -RRB- cord-005453-4057qib7 10944 22 . . . cord-005453-4057qib7 10945 1 Most Most JJS cord-005453-4057qib7 10945 2 of of IN cord-005453-4057qib7 10945 3 them -PRON- PRP cord-005453-4057qib7 10945 4 didn´t didn´t TO cord-005453-4057qib7 10945 5 achieve achieve VB cord-005453-4057qib7 10945 6 complete complete JJ cord-005453-4057qib7 10945 7 response response NN cord-005453-4057qib7 10945 8 prior prior RB cord-005453-4057qib7 10945 9 to to IN cord-005453-4057qib7 10945 10 transplant transplant NN cord-005453-4057qib7 10945 11 ( ( -LRB- cord-005453-4057qib7 10945 12 55 55 CD cord-005453-4057qib7 10945 13 % % NN cord-005453-4057qib7 10945 14 ) ) -RRB- cord-005453-4057qib7 10945 15 , , , cord-005453-4057qib7 10945 16 but but CC cord-005453-4057qib7 10945 17 only only RB cord-005453-4057qib7 10945 18 15 15 CD cord-005453-4057qib7 10945 19 % % NN cord-005453-4057qib7 10945 20 with with IN cord-005453-4057qib7 10945 21 active active JJ cord-005453-4057qib7 10945 22 disease disease NN cord-005453-4057qib7 10945 23 . . . cord-005453-4057qib7 10946 1 Up up IN cord-005453-4057qib7 10946 2 to to TO cord-005453-4057qib7 10946 3 63 63 CD cord-005453-4057qib7 10946 4 % % NN cord-005453-4057qib7 10946 5 of of IN cord-005453-4057qib7 10946 6 patients patient NNS cord-005453-4057qib7 10946 7 had have VBD cord-005453-4057qib7 10946 8 received receive VBN cord-005453-4057qib7 10946 9 previous previous JJ cord-005453-4057qib7 10946 10 transplant transplant NN cord-005453-4057qib7 10946 11 , , , cord-005453-4057qib7 10946 12 from from IN cord-005453-4057qib7 10946 13 which which WDT cord-005453-4057qib7 10946 14 5 5 CD cord-005453-4057qib7 10946 15 % % NN cord-005453-4057qib7 10946 16 was be VBD cord-005453-4057qib7 10946 17 an an DT cord-005453-4057qib7 10946 18 allogeneic allogeneic NN cord-005453-4057qib7 10946 19 transplantation transplantation NN cord-005453-4057qib7 10946 20 . . . cord-005453-4057qib7 10947 1 Source source NN cord-005453-4057qib7 10947 2 of of IN cord-005453-4057qib7 10947 3 stem stem NN cord-005453-4057qib7 10947 4 cells cell NNS cord-005453-4057qib7 10947 5 was be VBD cord-005453-4057qib7 10947 6 mainly mainly RB cord-005453-4057qib7 10947 7 peripheral peripheral JJ cord-005453-4057qib7 10947 8 blood blood NN cord-005453-4057qib7 10947 9 ( ( -LRB- cord-005453-4057qib7 10947 10 90 90 CD cord-005453-4057qib7 10947 11 % % NN cord-005453-4057qib7 10947 12 ) ) -RRB- cord-005453-4057qib7 10947 13 , , , cord-005453-4057qib7 10947 14 and and CC cord-005453-4057qib7 10947 15 reduced reduce VBN cord-005453-4057qib7 10947 16 intensity intensity NN cord-005453-4057qib7 10947 17 conditioning conditioning NN cord-005453-4057qib7 10947 18 was be VBD cord-005453-4057qib7 10947 19 the the DT cord-005453-4057qib7 10947 20 preferred preferred JJ cord-005453-4057qib7 10947 21 ( ( -LRB- cord-005453-4057qib7 10947 22 82 82 CD cord-005453-4057qib7 10947 23 % % NN cord-005453-4057qib7 10947 24 ) ) -RRB- cord-005453-4057qib7 10947 25 regimen regimen NN cord-005453-4057qib7 10947 26 . . . cord-005453-4057qib7 10948 1 Donors donor NNS cord-005453-4057qib7 10948 2 were be VBD cord-005453-4057qib7 10948 3 43 43 CD cord-005453-4057qib7 10948 4 % % NN cord-005453-4057qib7 10948 5 siblings sibling NNS cord-005453-4057qib7 10948 6 ( ( -LRB- cord-005453-4057qib7 10948 7 26 26 CD cord-005453-4057qib7 10948 8 ) ) -RRB- cord-005453-4057qib7 10948 9 , , , cord-005453-4057qib7 10948 10 38 38 CD cord-005453-4057qib7 10948 11 % % NN cord-005453-4057qib7 10948 12 offspring offspring NN cord-005453-4057qib7 10948 13 ( ( -LRB- cord-005453-4057qib7 10948 14 23 23 CD cord-005453-4057qib7 10948 15 ) ) -RRB- cord-005453-4057qib7 10948 16 , , , cord-005453-4057qib7 10948 17 and and CC cord-005453-4057qib7 10948 18 18 18 CD cord-005453-4057qib7 10948 19 % % NN cord-005453-4057qib7 10948 20 parents parent NNS cord-005453-4057qib7 10948 21 ( ( -LRB- cord-005453-4057qib7 10948 22 11 11 CD cord-005453-4057qib7 10948 23 ) ) -RRB- cord-005453-4057qib7 10948 24 . . . cord-005453-4057qib7 10949 1 Median median JJ cord-005453-4057qib7 10949 2 neutrophil neutrophil NN cord-005453-4057qib7 10949 3 and and CC cord-005453-4057qib7 10949 4 platelet platelet NN cord-005453-4057qib7 10949 5 engraftment engraftment NN cord-005453-4057qib7 10949 6 was be VBD cord-005453-4057qib7 10949 7 18 18 CD cord-005453-4057qib7 10949 8 ( ( -LRB- cord-005453-4057qib7 10949 9 16 16 CD cord-005453-4057qib7 10949 10 - - SYM cord-005453-4057qib7 10949 11 21 21 CD cord-005453-4057qib7 10949 12 ) ) -RRB- cord-005453-4057qib7 10949 13 and and CC cord-005453-4057qib7 10949 14 28 28 CD cord-005453-4057qib7 10949 15 ( ( -LRB- cord-005453-4057qib7 10949 16 20 20 CD cord-005453-4057qib7 10949 17 - - SYM cord-005453-4057qib7 10949 18 42 42 CD cord-005453-4057qib7 10949 19 ) ) -RRB- cord-005453-4057qib7 10949 20 days day NNS cord-005453-4057qib7 10949 21 , , , cord-005453-4057qib7 10949 22 respectively respectively RB cord-005453-4057qib7 10949 23 . . . cord-005453-4057qib7 10950 1 Acute acute JJ cord-005453-4057qib7 10950 2 GVHD GVHD NNP cord-005453-4057qib7 10950 3 grade grade NN cord-005453-4057qib7 10950 4 II II NNP cord-005453-4057qib7 10950 5 - - HYPH cord-005453-4057qib7 10950 6 IV IV NNP cord-005453-4057qib7 10950 7 rate rate NN cord-005453-4057qib7 10950 8 was be VBD cord-005453-4057qib7 10950 9 55 55 CD cord-005453-4057qib7 10950 10 % % NN cord-005453-4057qib7 10950 11 , , , cord-005453-4057qib7 10950 12 with with IN cord-005453-4057qib7 10950 13 only only RB cord-005453-4057qib7 10950 14 6 6 CD cord-005453-4057qib7 10950 15 patients patient NNS cord-005453-4057qib7 10950 16 developing develop VBG cord-005453-4057qib7 10950 17 grade grade NN cord-005453-4057qib7 10950 18 III III NNP cord-005453-4057qib7 10950 19 - - HYPH cord-005453-4057qib7 10950 20 IV IV NNP cord-005453-4057qib7 10950 21 ( ( -LRB- cord-005453-4057qib7 10950 22 10 10 CD cord-005453-4057qib7 10950 23 % % NN cord-005453-4057qib7 10950 24 ) ) -RRB- cord-005453-4057qib7 10950 25 . . . cord-005453-4057qib7 10951 1 Chronic chronic JJ cord-005453-4057qib7 10951 2 GVHD GVHD NNP cord-005453-4057qib7 10951 3 rate rate NN cord-005453-4057qib7 10951 4 was be VBD cord-005453-4057qib7 10951 5 17 17 CD cord-005453-4057qib7 10951 6 % % NN cord-005453-4057qib7 10951 7 , , , cord-005453-4057qib7 10951 8 and and CC cord-005453-4057qib7 10951 9 only only RB cord-005453-4057qib7 10951 10 in in IN cord-005453-4057qib7 10951 11 3 3 CD cord-005453-4057qib7 10951 12 ( ( -LRB- cord-005453-4057qib7 10951 13 5 5 CD cord-005453-4057qib7 10951 14 % % NN cord-005453-4057qib7 10951 15 ) ) -RRB- cord-005453-4057qib7 10951 16 was be VBD cord-005453-4057qib7 10951 17 extensive extensive JJ cord-005453-4057qib7 10951 18 . . . cord-005453-4057qib7 10952 1 Median median JJ cord-005453-4057qib7 10952 2 follow follow NN cord-005453-4057qib7 10952 3 - - HYPH cord-005453-4057qib7 10952 4 up up NN cord-005453-4057qib7 10952 5 was be VBD cord-005453-4057qib7 10952 6 14 14 CD cord-005453-4057qib7 10952 7 months month NNS cord-005453-4057qib7 10952 8 . . . cord-005453-4057qib7 10953 1 The the DT cord-005453-4057qib7 10953 2 2-year 2-year CD cord-005453-4057qib7 10953 3 overall overall JJ cord-005453-4057qib7 10953 4 survival survival NN cord-005453-4057qib7 10953 5 and and CC cord-005453-4057qib7 10953 6 event event NN cord-005453-4057qib7 10953 7 free free JJ cord-005453-4057qib7 10953 8 survival survival NN cord-005453-4057qib7 10953 9 was be VBD cord-005453-4057qib7 10953 10 43 43 CD cord-005453-4057qib7 10953 11 % % NN cord-005453-4057qib7 10953 12 and and CC cord-005453-4057qib7 10953 13 39 39 CD cord-005453-4057qib7 10953 14 % % NN cord-005453-4057qib7 10953 15 , , , cord-005453-4057qib7 10953 16 respectively respectively RB cord-005453-4057qib7 10953 17 . . . cord-005453-4057qib7 10954 1 The the DT cord-005453-4057qib7 10954 2 2-year 2-year CD cord-005453-4057qib7 10954 3 cumulative cumulative JJ cord-005453-4057qib7 10954 4 incidence incidence NN cord-005453-4057qib7 10954 5 of of IN cord-005453-4057qib7 10954 6 relapse relapse NN cord-005453-4057qib7 10954 7 was be VBD cord-005453-4057qib7 10954 8 14 14 CD cord-005453-4057qib7 10954 9 % % NN cord-005453-4057qib7 10954 10 and and CC cord-005453-4057qib7 10954 11 2-year 2-year CD cord-005453-4057qib7 10954 12 cumulative cumulative JJ cord-005453-4057qib7 10954 13 incidence incidence NN cord-005453-4057qib7 10954 14 of of IN cord-005453-4057qib7 10954 15 NRM NRM NNP cord-005453-4057qib7 10954 16 was be VBD cord-005453-4057qib7 10954 17 22 22 CD cord-005453-4057qib7 10954 18 % % NN cord-005453-4057qib7 10954 19 . . . cord-005453-4057qib7 10955 1 Conclusions conclusion NNS cord-005453-4057qib7 10955 2 : : : cord-005453-4057qib7 10956 1 Relapsed relapsed JJ cord-005453-4057qib7 10956 2 / / SYM cord-005453-4057qib7 10956 3 refractory refractory JJ cord-005453-4057qib7 10956 4 NHL NHL NNP cord-005453-4057qib7 10956 5 are be VBP cord-005453-4057qib7 10956 6 aggressive aggressive JJ cord-005453-4057qib7 10956 7 entities entity NNS cord-005453-4057qib7 10956 8 with with IN cord-005453-4057qib7 10956 9 a a DT cord-005453-4057qib7 10956 10 fatal fatal JJ cord-005453-4057qib7 10956 11 course course NN cord-005453-4057qib7 10956 12 in in IN cord-005453-4057qib7 10956 13 a a DT cord-005453-4057qib7 10956 14 short short JJ cord-005453-4057qib7 10956 15 period period NN cord-005453-4057qib7 10956 16 of of IN cord-005453-4057qib7 10956 17 time time NN cord-005453-4057qib7 10956 18 . . . cord-005453-4057qib7 10957 1 HaploSCT HaploSCT NNP cord-005453-4057qib7 10958 1 with with IN cord-005453-4057qib7 10958 2 Pt Pt NNP cord-005453-4057qib7 10958 3 - - HYPH cord-005453-4057qib7 10958 4 Cy Cy NNP cord-005453-4057qib7 10958 5 permit permit VB cord-005453-4057qib7 10958 6 a a DT cord-005453-4057qib7 10958 7 new new JJ cord-005453-4057qib7 10958 8 treatment treatment NN cord-005453-4057qib7 10958 9 option option NN cord-005453-4057qib7 10958 10 among among IN cord-005453-4057qib7 10958 11 these these DT cord-005453-4057qib7 10958 12 patients patient NNS cord-005453-4057qib7 10958 13 , , , cord-005453-4057qib7 10958 14 with with IN cord-005453-4057qib7 10958 15 acceptable acceptable JJ cord-005453-4057qib7 10958 16 outcomes outcome NNS cord-005453-4057qib7 10958 17 . . . cord-005453-4057qib7 10959 1 More More JJR cord-005453-4057qib7 10959 2 studies study NNS cord-005453-4057qib7 10959 3 are be VBP cord-005453-4057qib7 10959 4 needed need VBN cord-005453-4057qib7 10959 5 with with IN cord-005453-4057qib7 10959 6 a a DT cord-005453-4057qib7 10959 7 larger large JJR cord-005453-4057qib7 10959 8 cohort cohort NN cord-005453-4057qib7 10959 9 of of IN cord-005453-4057qib7 10959 10 patients patient NNS cord-005453-4057qib7 10959 11 and and CC cord-005453-4057qib7 10959 12 longer long RBR cord-005453-4057qib7 10959 13 follow follow VB cord-005453-4057qib7 10959 14 - - HYPH cord-005453-4057qib7 10959 15 up up NN cord-005453-4057qib7 10959 16 to to TO cord-005453-4057qib7 10959 17 confirm confirm VB cord-005453-4057qib7 10959 18 these these DT cord-005453-4057qib7 10959 19 results result NNS cord-005453-4057qib7 10959 20 . . . cord-005453-4057qib7 10960 1 Disclosure disclosure NN cord-005453-4057qib7 10960 2 : : : cord-005453-4057qib7 10960 3 Nothing nothing NN cord-005453-4057qib7 10960 4 to to TO cord-005453-4057qib7 10960 5 disclose disclose VB cord-005453-4057qib7 10960 6 . . . cord-005453-4057qib7 10961 1 Higher high JJR cord-005453-4057qib7 10961 2 SUV SUV NNP cord-005453-4057qib7 10961 3 at at IN cord-005453-4057qib7 10961 4 pre pre JJ cord-005453-4057qib7 10961 5 - - NN cord-005453-4057qib7 10961 6 transplant transplant NN cord-005453-4057qib7 10961 7 and and CC cord-005453-4057qib7 10961 8 day day NN cord-005453-4057qib7 10961 9 100 100 CD cord-005453-4057qib7 10962 1 posttransplant posttransplant NNP cord-005453-4057qib7 10962 2 pet pet NNP cord-005453-4057qib7 10962 3 scan scan NNP cord-005453-4057qib7 10962 4 both both DT cord-005453-4057qib7 10962 5 independently independently RB cord-005453-4057qib7 10962 6 predict predict VBP cord-005453-4057qib7 10962 7 inferior inferior JJ cord-005453-4057qib7 10962 8 survival survival NN cord-005453-4057qib7 10962 9 in in IN cord-005453-4057qib7 10962 10 patients patient NNS cord-005453-4057qib7 10962 11 with with IN cord-005453-4057qib7 10962 12 diffuse diffuse JJ cord-005453-4057qib7 10962 13 large large JJ cord-005453-4057qib7 10962 14 B b NN cord-005453-4057qib7 10962 15 cell cell NN cord-005453-4057qib7 10962 16 lymphoma lymphoma NN cord-005453-4057qib7 10962 17 Background background NN cord-005453-4057qib7 10962 18 : : : cord-005453-4057qib7 10963 1 Autologous autologous JJ cord-005453-4057qib7 10963 2 stem stem NN cord-005453-4057qib7 10963 3 cell cell NN cord-005453-4057qib7 10963 4 transplant transplant NN cord-005453-4057qib7 10963 5 ( ( -LRB- cord-005453-4057qib7 10963 6 auto auto NN cord-005453-4057qib7 10963 7 - - HYPH cord-005453-4057qib7 10963 8 HCT HCT NNP cord-005453-4057qib7 10963 9 ) ) -RRB- cord-005453-4057qib7 10963 10 can can MD cord-005453-4057qib7 10963 11 cure cure VB cord-005453-4057qib7 10963 12 some some DT cord-005453-4057qib7 10963 13 patients patient NNS cord-005453-4057qib7 10963 14 with with IN cord-005453-4057qib7 10963 15 relapsed relapse VBN cord-005453-4057qib7 10963 16 diffuse diffuse JJ cord-005453-4057qib7 10963 17 large large JJ cord-005453-4057qib7 10963 18 B b NN cord-005453-4057qib7 10963 19 - - HYPH cord-005453-4057qib7 10963 20 cell cell NN cord-005453-4057qib7 10963 21 lymphoma lymphoma NN cord-005453-4057qib7 10963 22 ( ( -LRB- cord-005453-4057qib7 10963 23 DLBCL DLBCL NNP cord-005453-4057qib7 10963 24 ) ) -RRB- cord-005453-4057qib7 10963 25 but but CC cord-005453-4057qib7 10963 26 relapse relapse NN cord-005453-4057qib7 10963 27 occurs occur VBZ cord-005453-4057qib7 10963 28 in in IN cord-005453-4057qib7 10963 29 about about RB cord-005453-4057qib7 10963 30 50 50 CD cord-005453-4057qib7 10963 31 % % NN cord-005453-4057qib7 10963 32 of of IN cord-005453-4057qib7 10963 33 patients patient NNS cord-005453-4057qib7 10963 34 . . . cord-005453-4057qib7 10964 1 While while IN cord-005453-4057qib7 10964 2 our -PRON- PRP$ cord-005453-4057qib7 10964 3 center center NN cord-005453-4057qib7 10964 4 and and CC cord-005453-4057qib7 10964 5 others other NNS cord-005453-4057qib7 10964 6 utilize utilize VBP cord-005453-4057qib7 10964 7 routine routine JJ cord-005453-4057qib7 10964 8 surveillance surveillance NN cord-005453-4057qib7 10964 9 imaging image VBG cord-005453-4057qib7 10964 10 post post JJ cord-005453-4057qib7 10964 11 - - NN cord-005453-4057qib7 10964 12 transplant transplant NN cord-005453-4057qib7 10964 13 , , , cord-005453-4057qib7 10964 14 the the DT cord-005453-4057qib7 10964 15 utility utility NN cord-005453-4057qib7 10964 16 in in IN cord-005453-4057qib7 10964 17 this this DT cord-005453-4057qib7 10964 18 setting setting NN cord-005453-4057qib7 10964 19 is be VBZ cord-005453-4057qib7 10964 20 unclear unclear JJ cord-005453-4057qib7 10964 21 . . . cord-005453-4057qib7 10965 1 Imaging imaging NN cord-005453-4057qib7 10965 2 is be VBZ cord-005453-4057qib7 10965 3 costly costly JJ cord-005453-4057qib7 10965 4 and and CC cord-005453-4057qib7 10965 5 exposes expose VBZ cord-005453-4057qib7 10965 6 patients patient NNS cord-005453-4057qib7 10965 7 to to IN cord-005453-4057qib7 10965 8 radiation radiation NN cord-005453-4057qib7 10965 9 . . . cord-005453-4057qib7 10966 1 Novel novel JJ cord-005453-4057qib7 10966 2 interventions intervention NNS cord-005453-4057qib7 10966 3 are be VBP cord-005453-4057qib7 10966 4 now now RB cord-005453-4057qib7 10966 5 available available JJ cord-005453-4057qib7 10966 6 for for IN cord-005453-4057qib7 10966 7 patients patient NNS cord-005453-4057qib7 10966 8 relapsing relapse VBG cord-005453-4057qib7 10966 9 after after IN cord-005453-4057qib7 10966 10 auto auto NN cord-005453-4057qib7 10966 11 - - HYPH cord-005453-4057qib7 10966 12 HCT hct NN cord-005453-4057qib7 10966 13 making make VBG cord-005453-4057qib7 10966 14 early early JJ cord-005453-4057qib7 10966 15 disease disease NN cord-005453-4057qib7 10966 16 recognition recognition NN cord-005453-4057qib7 10966 17 crucial crucial JJ cord-005453-4057qib7 10966 18 to to TO cord-005453-4057qib7 10966 19 intervene intervene VB cord-005453-4057qib7 10966 20 prior prior RB cord-005453-4057qib7 10966 21 to to IN cord-005453-4057qib7 10966 22 clinical clinical JJ cord-005453-4057qib7 10966 23 progression progression NN cord-005453-4057qib7 10966 24 . . . cord-005453-4057qib7 10967 1 Hence hence RB cord-005453-4057qib7 10967 2 , , , cord-005453-4057qib7 10967 3 we -PRON- PRP cord-005453-4057qib7 10967 4 studied study VBD cord-005453-4057qib7 10967 5 impact impact NN cord-005453-4057qib7 10967 6 of of IN cord-005453-4057qib7 10967 7 post post JJ cord-005453-4057qib7 10967 8 - - JJ cord-005453-4057qib7 10967 9 auto auto JJ cord-005453-4057qib7 10967 10 - - HYPH cord-005453-4057qib7 10967 11 HCT hct NN cord-005453-4057qib7 10967 12 surveillance surveillance NN cord-005453-4057qib7 10967 13 ( ( -LRB- cord-005453-4057qib7 10967 14 18)F 18)F NNP cord-005453-4057qib7 10967 15 - - HYPH cord-005453-4057qib7 10967 16 FDG FDG NNP cord-005453-4057qib7 10967 17 - - HYPH cord-005453-4057qib7 10967 18 PET PET NNP cord-005453-4057qib7 10967 19 CT CT NNP cord-005453-4057qib7 10967 20 at at IN cord-005453-4057qib7 10967 21 day day NN cord-005453-4057qib7 10967 22 100 100 CD cord-005453-4057qib7 10967 23 on on IN cord-005453-4057qib7 10967 24 transplant transplant NN cord-005453-4057qib7 10967 25 outcomes outcome NNS cord-005453-4057qib7 10967 26 . . . cord-005453-4057qib7 10968 1 Methods method NNS cord-005453-4057qib7 10968 2 : : : cord-005453-4057qib7 10968 3 We -PRON- PRP cord-005453-4057qib7 10968 4 analyzed analyze VBD cord-005453-4057qib7 10968 5 a a DT cord-005453-4057qib7 10968 6 cohort cohort NN cord-005453-4057qib7 10968 7 of of IN cord-005453-4057qib7 10968 8 131 131 CD cord-005453-4057qib7 10968 9 consecutive consecutive JJ cord-005453-4057qib7 10968 10 auto auto NN cord-005453-4057qib7 10968 11 - - HYPH cord-005453-4057qib7 10968 12 HCT hct NN cord-005453-4057qib7 10968 13 recipients recipient NNS cord-005453-4057qib7 10968 14 with with IN cord-005453-4057qib7 10968 15 relapsed relapse VBN cord-005453-4057qib7 10968 16 / / SYM cord-005453-4057qib7 10968 17 refractory refractory JJ cord-005453-4057qib7 10968 18 DLBCL DLBCL NNP cord-005453-4057qib7 10968 19 who who WP cord-005453-4057qib7 10968 20 then then RB cord-005453-4057qib7 10968 21 underwent undergo VBD cord-005453-4057qib7 10968 22 pre pre JJ cord-005453-4057qib7 10968 23 - - JJ cord-005453-4057qib7 10968 24 transplant transplant JJ cord-005453-4057qib7 10968 25 PET PET NNP cord-005453-4057qib7 10968 26 / / SYM cord-005453-4057qib7 10968 27 CT CT NNP cord-005453-4057qib7 10968 28 and and CC cord-005453-4057qib7 10968 29 surveillance surveillance NN cord-005453-4057qib7 10968 30 PET PET NNP cord-005453-4057qib7 10968 31 CT CT NNP cord-005453-4057qib7 10968 32 at at IN cord-005453-4057qib7 10968 33 day day NN cord-005453-4057qib7 10968 34 100 100 CD cord-005453-4057qib7 10968 35 ( ( -LRB- cord-005453-4057qib7 10968 36 Interquartile Interquartile NNP cord-005453-4057qib7 10968 37 range range NN cord-005453-4057qib7 10968 38 ( ( -LRB- cord-005453-4057qib7 10968 39 IQR IQR NNP cord-005453-4057qib7 10968 40 ) ) -RRB- cord-005453-4057qib7 10968 41 : : : cord-005453-4057qib7 10968 42 97 97 CD cord-005453-4057qib7 10968 43 - - SYM cord-005453-4057qib7 10968 44 103 103 CD cord-005453-4057qib7 10968 45 days day NNS cord-005453-4057qib7 10968 46 ) ) -RRB- cord-005453-4057qib7 10969 1 post post JJ cord-005453-4057qib7 10969 2 - - NN cord-005453-4057qib7 10969 3 HCT HCT NNP cord-005453-4057qib7 10969 4 at at IN cord-005453-4057qib7 10969 5 the the DT cord-005453-4057qib7 10969 6 University University NNP cord-005453-4057qib7 10969 7 of of IN cord-005453-4057qib7 10969 8 Minnesota Minnesota NNP cord-005453-4057qib7 10969 9 Medical Medical NNP cord-005453-4057qib7 10969 10 Center Center NNP cord-005453-4057qib7 10969 11 . . . cord-005453-4057qib7 10970 1 Univariate Univariate NNP cord-005453-4057qib7 10970 2 analysis analysis NN cord-005453-4057qib7 10970 3 was be VBD cord-005453-4057qib7 10970 4 performed perform VBN cord-005453-4057qib7 10970 5 to to TO cord-005453-4057qib7 10970 6 analyze analyze VB cord-005453-4057qib7 10970 7 PET pet NN cord-005453-4057qib7 10970 8 parameters parameter NNS cord-005453-4057qib7 10970 9 including include VBG cord-005453-4057qib7 10970 10 Deauville Deauville NNP cord-005453-4057qib7 10970 11 score score NN cord-005453-4057qib7 10970 12 ( ( -LRB- cord-005453-4057qib7 10970 13 D D NNP cord-005453-4057qib7 10970 14 ) ) -RRB- cord-005453-4057qib7 10970 15 , , , cord-005453-4057qib7 10970 16 standardized standardized JJ cord-005453-4057qib7 10970 17 uptake uptake NN cord-005453-4057qib7 10970 18 values value NNS cord-005453-4057qib7 10970 19 ( ( -LRB- cord-005453-4057qib7 10970 20 SUV SUV NNP cord-005453-4057qib7 10970 21 ) ) -RRB- cord-005453-4057qib7 10970 22 , , , cord-005453-4057qib7 10970 23 total total JJ cord-005453-4057qib7 10970 24 lesion lesion NN cord-005453-4057qib7 10970 25 glycolysis glycolysis NN cord-005453-4057qib7 10970 26 ( ( -LRB- cord-005453-4057qib7 10970 27 TLG TLG NNP cord-005453-4057qib7 10970 28 ) ) -RRB- cord-005453-4057qib7 10970 29 and and CC cord-005453-4057qib7 10970 30 total total JJ cord-005453-4057qib7 10970 31 metabolic metabolic JJ cord-005453-4057qib7 10970 32 tumor tumor NN cord-005453-4057qib7 10970 33 volume volume NN cord-005453-4057qib7 10970 34 ( ( -LRB- cord-005453-4057qib7 10970 35 TMTV TMTV NNP cord-005453-4057qib7 10970 36 ) ) -RRB- cord-005453-4057qib7 10970 37 as as IN cord-005453-4057qib7 10970 38 predictors predictor NNS cord-005453-4057qib7 10970 39 of of IN cord-005453-4057qib7 10970 40 relapse relapse NN cord-005453-4057qib7 10970 41 and and CC cord-005453-4057qib7 10970 42 survival survival NN cord-005453-4057qib7 10970 43 after after IN cord-005453-4057qib7 10970 44 auto auto NN cord-005453-4057qib7 10970 45 - - HYPH cord-005453-4057qib7 10970 46 HCT hct NN cord-005453-4057qib7 10970 47 . . . cord-005453-4057qib7 10971 1 In in IN cord-005453-4057qib7 10971 2 addition addition NN cord-005453-4057qib7 10971 3 , , , cord-005453-4057qib7 10971 4 we -PRON- PRP cord-005453-4057qib7 10971 5 assessed assess VBD cord-005453-4057qib7 10971 6 outcomes outcome NNS cord-005453-4057qib7 10971 7 of of IN cord-005453-4057qib7 10971 8 patients patient NNS cord-005453-4057qib7 10971 9 with with IN cord-005453-4057qib7 10971 10 clinically clinically RB cord-005453-4057qib7 10971 11 versus versus IN cord-005453-4057qib7 10971 12 radiographically radiographically RB cord-005453-4057qib7 10971 13 detected detect VBN cord-005453-4057qib7 10971 14 relapsed relapse VBN cord-005453-4057qib7 10971 15 DLBCL DLBCL NNP cord-005453-4057qib7 10971 16 after after IN cord-005453-4057qib7 10971 17 auto auto NN cord-005453-4057qib7 10971 18 - - HYPH cord-005453-4057qib7 10971 19 HCT hct NN cord-005453-4057qib7 10971 20 . . . cord-005453-4057qib7 10972 1 Other other JJ cord-005453-4057qib7 10972 2 pre pre JJ cord-005453-4057qib7 10972 3 - - JJ cord-005453-4057qib7 10972 4 HCT hct JJ cord-005453-4057qib7 10972 5 factors factor NNS cord-005453-4057qib7 10972 6 analyzed analyze VBD cord-005453-4057qib7 10972 7 included include VBN cord-005453-4057qib7 10972 8 age age NN cord-005453-4057qib7 10972 9 , , , cord-005453-4057qib7 10972 10 gender gender NN cord-005453-4057qib7 10972 11 , , , cord-005453-4057qib7 10972 12 conditioning conditioning NN cord-005453-4057qib7 10972 13 regimen regimen NN cord-005453-4057qib7 10972 14 , , , cord-005453-4057qib7 10972 15 performance performance NN cord-005453-4057qib7 10972 16 status status NN cord-005453-4057qib7 10972 17 , , , cord-005453-4057qib7 10972 18 consolidation consolidation NN cord-005453-4057qib7 10972 19 radiation radiation NN cord-005453-4057qib7 10972 20 therapy therapy NN cord-005453-4057qib7 10972 21 , , , cord-005453-4057qib7 10972 22 TMTV TMTV NNP cord-005453-4057qib7 10972 23 , , , cord-005453-4057qib7 10972 24 SUV SUV NNP cord-005453-4057qib7 10972 25 , , , cord-005453-4057qib7 10972 26 TLG TLG NNP cord-005453-4057qib7 10972 27 . . . cord-005453-4057qib7 10973 1 Results result NNS cord-005453-4057qib7 10973 2 : : : cord-005453-4057qib7 10974 1 Five five CD cord-005453-4057qib7 10974 2 - - HYPH cord-005453-4057qib7 10974 3 year year NN cord-005453-4057qib7 10974 4 cumulative cumulative JJ cord-005453-4057qib7 10974 5 incidence incidence NN cord-005453-4057qib7 10974 6 of of IN cord-005453-4057qib7 10974 7 relapse relapse NN cord-005453-4057qib7 10974 8 after after IN cord-005453-4057qib7 10974 9 auto auto NN cord-005453-4057qib7 10974 10 - - HYPH cord-005453-4057qib7 10974 11 HCT HCT NNP cord-005453-4057qib7 10974 12 was be VBD cord-005453-4057qib7 10974 13 50 50 CD cord-005453-4057qib7 10974 14 % % NN cord-005453-4057qib7 10974 15 ( ( -LRB- cord-005453-4057qib7 10974 16 95%CI 95%ci CD cord-005453-4057qib7 10974 17 39 39 CD cord-005453-4057qib7 10974 18 to to IN cord-005453-4057qib7 10974 19 59 59 CD cord-005453-4057qib7 10974 20 ) ) -RRB- cord-005453-4057qib7 10974 21 and and CC cord-005453-4057qib7 10974 22 overall overall JJ cord-005453-4057qib7 10974 23 survival survival NN cord-005453-4057qib7 10974 24 ( ( -LRB- cord-005453-4057qib7 10974 25 OS OS NNP cord-005453-4057qib7 10974 26 ) ) -RRB- cord-005453-4057qib7 10974 27 was be VBD cord-005453-4057qib7 10974 28 51 51 CD cord-005453-4057qib7 10974 29 % % NN cord-005453-4057qib7 10974 30 ( ( -LRB- cord-005453-4057qib7 10974 31 95 95 CD cord-005453-4057qib7 10974 32 % % NN cord-005453-4057qib7 10974 33 CI CI NNP cord-005453-4057qib7 10974 34 41 41 CD cord-005453-4057qib7 10974 35 to to IN cord-005453-4057qib7 10974 36 63 63 CD cord-005453-4057qib7 10974 37 ) ) -RRB- cord-005453-4057qib7 10974 38 . . . cord-005453-4057qib7 10975 1 Twelve twelve CD cord-005453-4057qib7 10975 2 ( ( -LRB- cord-005453-4057qib7 10975 3 9 9 CD cord-005453-4057qib7 10975 4 % % NN cord-005453-4057qib7 10975 5 ) ) -RRB- cord-005453-4057qib7 10975 6 relapsed relapse VBN cord-005453-4057qib7 10975 7 prior prior RB cord-005453-4057qib7 10975 8 to to IN cord-005453-4057qib7 10975 9 day day NN cord-005453-4057qib7 10975 10 100 100 CD cord-005453-4057qib7 10975 11 . . . cord-005453-4057qib7 10976 1 D d NN cord-005453-4057qib7 10976 2 - - HYPH cord-005453-4057qib7 10976 3 score score NN cord-005453-4057qib7 10976 4 for for IN cord-005453-4057qib7 10976 5 91 91 CD cord-005453-4057qib7 10976 6 patients patient NNS cord-005453-4057qib7 10976 7 with with IN cord-005453-4057qib7 10976 8 d100 d100 NNP cord-005453-4057qib7 10976 9 PET PET NNP cord-005453-4057qib7 10976 10 / / SYM cord-005453-4057qib7 10976 11 CT CT NNP cord-005453-4057qib7 10976 12 were be VBD cord-005453-4057qib7 10976 13 D1 d1 NN cord-005453-4057qib7 10976 14 ( ( -LRB- cord-005453-4057qib7 10976 15 22 22 CD cord-005453-4057qib7 10976 16 % % NN cord-005453-4057qib7 10976 17 ) ) -RRB- cord-005453-4057qib7 10976 18 , , , cord-005453-4057qib7 10976 19 D2 d2 NN cord-005453-4057qib7 10976 20 ( ( -LRB- cord-005453-4057qib7 10976 21 55 55 CD cord-005453-4057qib7 10976 22 % % NN cord-005453-4057qib7 10976 23 ) ) -RRB- cord-005453-4057qib7 10976 24 , , , cord-005453-4057qib7 10976 25 D3 D3 NNP cord-005453-4057qib7 10976 26 ( ( -LRB- cord-005453-4057qib7 10976 27 0 0 CD cord-005453-4057qib7 10976 28 % % NN cord-005453-4057qib7 10976 29 ) ) -RRB- cord-005453-4057qib7 10976 30 , , , cord-005453-4057qib7 10976 31 D4 D4 NNP cord-005453-4057qib7 10976 32 ( ( -LRB- cord-005453-4057qib7 10976 33 10 10 CD cord-005453-4057qib7 10976 34 % % NN cord-005453-4057qib7 10976 35 ) ) -RRB- cord-005453-4057qib7 10976 36 , , , cord-005453-4057qib7 10976 37 D5 D5 NNP cord-005453-4057qib7 10976 38 ( ( -LRB- cord-005453-4057qib7 10976 39 13 13 CD cord-005453-4057qib7 10976 40 % % NN cord-005453-4057qib7 10976 41 ) ) -RRB- cord-005453-4057qib7 10976 42 with with IN cord-005453-4057qib7 10976 43 median median JJ cord-005453-4057qib7 10976 44 survival survival NN cord-005453-4057qib7 10976 45 in in IN cord-005453-4057qib7 10976 46 years year NNS cord-005453-4057qib7 10976 47 for for IN cord-005453-4057qib7 10976 48 D1 d1 NN cord-005453-4057qib7 10976 49 , , , cord-005453-4057qib7 10976 50 D2 d2 NN cord-005453-4057qib7 10976 51 , , , cord-005453-4057qib7 10976 52 D4 d4 NN cord-005453-4057qib7 10976 53 and and CC cord-005453-4057qib7 10976 54 D5 d5 NN cord-005453-4057qib7 10976 55 of of IN cord-005453-4057qib7 10976 56 6.0 6.0 CD cord-005453-4057qib7 10976 57 , , , cord-005453-4057qib7 10976 58 6.8 6.8 CD cord-005453-4057qib7 10976 59 , , , cord-005453-4057qib7 10976 60 4.7 4.7 CD cord-005453-4057qib7 10976 61 , , , cord-005453-4057qib7 10976 62 and and CC cord-005453-4057qib7 10976 63 1.2 1.2 CD cord-005453-4057qib7 10976 64 , , , cord-005453-4057qib7 10976 65 respectively respectively RB cord-005453-4057qib7 10976 66 . . . cord-005453-4057qib7 10977 1 Mean mean JJ cord-005453-4057qib7 10977 2 SUV SUV NNP cord-005453-4057qib7 10977 3 varied vary VBN cord-005453-4057qib7 10977 4 from from IN cord-005453-4057qib7 10977 5 1.53 1.53 CD cord-005453-4057qib7 10977 6 ( ( -LRB- cord-005453-4057qib7 10977 7 D1 d1 NN cord-005453-4057qib7 10977 8 ) ) -RRB- cord-005453-4057qib7 10977 9 to to IN cord-005453-4057qib7 10977 10 17.9 17.9 CD cord-005453-4057qib7 10977 11 ( ( -LRB- cord-005453-4057qib7 10977 12 D5 D5 NNP cord-005453-4057qib7 10977 13 ) ) -RRB- cord-005453-4057qib7 10977 14 . . . cord-005453-4057qib7 10978 1 SUV SUV NNP cord-005453-4057qib7 10978 2 was be VBD cord-005453-4057qib7 10978 3 predictive predictive JJ cord-005453-4057qib7 10978 4 of of IN cord-005453-4057qib7 10978 5 relapse relapse NN cord-005453-4057qib7 10978 6 and and CC cord-005453-4057qib7 10978 7 OS os NN cord-005453-4057qib7 10978 8 . . . cord-005453-4057qib7 10979 1 Risk risk NN cord-005453-4057qib7 10979 2 of of IN cord-005453-4057qib7 10979 3 relapse relapse NN cord-005453-4057qib7 10979 4 increased increase VBD cord-005453-4057qib7 10979 5 with with IN cord-005453-4057qib7 10979 6 doubling double VBG cord-005453-4057qib7 10979 7 of of IN cord-005453-4057qib7 10979 8 SUV SUV NNP cord-005453-4057qib7 10979 9 ; ; : cord-005453-4057qib7 10979 10 2-fold 2-fold CD cord-005453-4057qib7 10979 11 higher high JJR cord-005453-4057qib7 10979 12 SUV SUV NNP cord-005453-4057qib7 10979 13 increased increase VBD cord-005453-4057qib7 10979 14 HR hr NN cord-005453-4057qib7 10979 15 by by IN cord-005453-4057qib7 10979 16 1.77 1.77 CD cord-005453-4057qib7 10979 17 ( ( -LRB- cord-005453-4057qib7 10979 18 95%CI 95%ci CD cord-005453-4057qib7 10979 19 1.34 1.34 CD cord-005453-4057qib7 10979 20 - - HYPH cord-005453-4057qib7 10979 21 2.33 2.33 CD cord-005453-4057qib7 10979 22 ; ; : cord-005453-4057qib7 10979 23 p= p= NN cord-005453-4057qib7 10979 24 0.01 0.01 CD cord-005453-4057qib7 10979 25 ) ) -RRB- cord-005453-4057qib7 10979 26 . . . cord-005453-4057qib7 10980 1 Mortality mortality NN cord-005453-4057qib7 10980 2 increased increase VBD cord-005453-4057qib7 10980 3 with with IN cord-005453-4057qib7 10980 4 doubling double VBG cord-005453-4057qib7 10980 5 of of IN cord-005453-4057qib7 10980 6 SUV suv NN cord-005453-4057qib7 10980 7 in in IN cord-005453-4057qib7 10980 8 both both DT cord-005453-4057qib7 10980 9 pre pre JJ cord-005453-4057qib7 10980 10 - - JJ cord-005453-4057qib7 10980 11 HCT hct JJ cord-005453-4057qib7 10980 12 ( ( -LRB- cord-005453-4057qib7 10980 13 2-fold 2-fold CD cord-005453-4057qib7 10980 14 increase increase NN cord-005453-4057qib7 10980 15 in in IN cord-005453-4057qib7 10980 16 SUV SUV NNP cord-005453-4057qib7 10980 17 associated associate VBN cord-005453-4057qib7 10980 18 with with IN cord-005453-4057qib7 10980 19 HR hr NN cord-005453-4057qib7 10980 20 1.46 1.46 CD cord-005453-4057qib7 10980 21 [ [ -LRB- cord-005453-4057qib7 10980 22 95 95 CD cord-005453-4057qib7 10980 23 % % NN cord-005453-4057qib7 10980 24 CI CI NNP cord-005453-4057qib7 10980 25 1.1 1.1 CD cord-005453-4057qib7 10980 26 to to IN cord-005453-4057qib7 10980 27 1.8 1.8 CD cord-005453-4057qib7 10980 28 ] ] -RRB- cord-005453-4057qib7 10980 29 ; ; : cord-005453-4057qib7 10980 30 p=0.01 p=0.01 NNP cord-005453-4057qib7 10980 31 ) ) -RRB- cord-005453-4057qib7 10980 32 as as RB cord-005453-4057qib7 10980 33 well well RB cord-005453-4057qib7 10980 34 as as IN cord-005453-4057qib7 10980 35 post post JJ cord-005453-4057qib7 10980 36 - - JJ cord-005453-4057qib7 10980 37 HCT hct JJ cord-005453-4057qib7 10980 38 PET pet NN cord-005453-4057qib7 10981 1 ( ( -LRB- cord-005453-4057qib7 10981 2 HR HR NNP cord-005453-4057qib7 10981 3 1.7 1.7 CD cord-005453-4057qib7 10981 4 [ [ -LRB- cord-005453-4057qib7 10981 5 95 95 CD cord-005453-4057qib7 10981 6 % % NN cord-005453-4057qib7 10981 7 CI CI NNP cord-005453-4057qib7 10982 1 1.3 1.3 CD cord-005453-4057qib7 10982 2 to to IN cord-005453-4057qib7 10982 3 2.3 2.3 CD cord-005453-4057qib7 10982 4 ] ] -RRB- cord-005453-4057qib7 10982 5 ; ; : cord-005453-4057qib7 10982 6 p=0 p=0 NNP cord-005453-4057qib7 10982 7 ) ) -RRB- cord-005453-4057qib7 10982 8 irrespective irrespective RB cord-005453-4057qib7 10982 9 of of IN cord-005453-4057qib7 10982 10 the the DT cord-005453-4057qib7 10982 11 bulk bulk NN cord-005453-4057qib7 10982 12 of of IN cord-005453-4057qib7 10982 13 tumor tumor NN cord-005453-4057qib7 10982 14 . . . cord-005453-4057qib7 10983 1 In in IN cord-005453-4057qib7 10983 2 addition addition NN cord-005453-4057qib7 10983 3 , , , cord-005453-4057qib7 10983 4 risk risk NN cord-005453-4057qib7 10983 5 of of IN cord-005453-4057qib7 10983 6 death death NN cord-005453-4057qib7 10983 7 was be VBD cord-005453-4057qib7 10983 8 4 4 CD cord-005453-4057qib7 10983 9 times time NNS cord-005453-4057qib7 10983 10 higher high JJR cord-005453-4057qib7 10983 11 in in IN cord-005453-4057qib7 10983 12 D5 D5 NNP cord-005453-4057qib7 10983 13 patients patient NNS cord-005453-4057qib7 10983 14 relative relative JJ cord-005453-4057qib7 10983 15 to to IN cord-005453-4057qib7 10983 16 D1 d1 NN cord-005453-4057qib7 10983 17 ( ( -LRB- cord-005453-4057qib7 10983 18 HR hr NN cord-005453-4057qib7 10983 19 4.10 4.10 CD cord-005453-4057qib7 10983 20 [ [ -LRB- cord-005453-4057qib7 10983 21 95 95 CD cord-005453-4057qib7 10983 22 % % NN cord-005453-4057qib7 10983 23 CI ci NN cord-005453-4057qib7 10983 24 = = SYM cord-005453-4057qib7 10983 25 1.56 1.56 CD cord-005453-4057qib7 10983 26 to to IN cord-005453-4057qib7 10983 27 10.77 10.77 CD cord-005453-4057qib7 10983 28 ] ] -RRB- cord-005453-4057qib7 10983 29 ; ; : cord-005453-4057qib7 10983 30 p≤0.01 p≤0.01 LS cord-005453-4057qib7 10983 31 ) ) -RRB- cord-005453-4057qib7 10983 32 . . . cord-005453-4057qib7 10984 1 Patients patient NNS cord-005453-4057qib7 10984 2 with with IN cord-005453-4057qib7 10984 3 D5 D5 NNP cord-005453-4057qib7 10984 4 ( ( -LRB- cord-005453-4057qib7 10984 5 n=12 n=12 NNP cord-005453-4057qib7 10984 6 ) ) -RRB- cord-005453-4057qib7 10984 7 had have VBD cord-005453-4057qib7 10984 8 higher high JJR cord-005453-4057qib7 10984 9 TMTV TMTV NNS cord-005453-4057qib7 10984 10 ( ( -LRB- cord-005453-4057qib7 10984 11 137 137 CD cord-005453-4057qib7 10984 12 cm cm NNS cord-005453-4057qib7 10984 13 3 3 CD cord-005453-4057qib7 10984 14 ) ) -RRB- cord-005453-4057qib7 10984 15 compared compare VBN cord-005453-4057qib7 10984 16 to to IN cord-005453-4057qib7 10984 17 D4 D4 NNP cord-005453-4057qib7 10984 18 ( ( -LRB- cord-005453-4057qib7 10984 19 n=9 n=9 NN cord-005453-4057qib7 10984 20 , , , cord-005453-4057qib7 10984 21 TMTV TMTV NNP cord-005453-4057qib7 10984 22 12.5 12.5 CD cord-005453-4057qib7 10984 23 cm cm NNS cord-005453-4057qib7 10984 24 3 3 CD cord-005453-4057qib7 10984 25 ) ) -RRB- cord-005453-4057qib7 10984 26 . . . cord-005453-4057qib7 10985 1 The the DT cord-005453-4057qib7 10985 2 hazard hazard NN cord-005453-4057qib7 10985 3 ratio ratio NN cord-005453-4057qib7 10985 4 for for IN cord-005453-4057qib7 10985 5 death death NN cord-005453-4057qib7 10985 6 following follow VBG cord-005453-4057qib7 10985 7 relapse relapse NN cord-005453-4057qib7 10985 8 was be VBD cord-005453-4057qib7 10985 9 2-fold 2-fold CD cord-005453-4057qib7 10985 10 higher high JJR cord-005453-4057qib7 10985 11 ( ( -LRB- cord-005453-4057qib7 10985 12 HR HR NNP cord-005453-4057qib7 10985 13 1.8 1.8 CD cord-005453-4057qib7 10985 14 [ [ -LRB- cord-005453-4057qib7 10985 15 95 95 CD cord-005453-4057qib7 10985 16 % % NN cord-005453-4057qib7 10985 17 CI CI NNP cord-005453-4057qib7 10985 18 0.9 0.9 CD cord-005453-4057qib7 10985 19 to to IN cord-005453-4057qib7 10985 20 3.4 3.4 CD cord-005453-4057qib7 10985 21 ] ] -RRB- cord-005453-4057qib7 10985 22 ; ; : cord-005453-4057qib7 10985 23 p=0.08 p=0.08 NNP cord-005453-4057qib7 10985 24 ) ) -RRB- cord-005453-4057qib7 10985 25 if if IN cord-005453-4057qib7 10985 26 relapse relapse NN cord-005453-4057qib7 10985 27 was be VBD cord-005453-4057qib7 10985 28 detected detect VBN cord-005453-4057qib7 10985 29 clinically clinically RB cord-005453-4057qib7 10985 30 versus versus IN cord-005453-4057qib7 10985 31 only only RB cord-005453-4057qib7 10985 32 radiographically radiographically RB cord-005453-4057qib7 10985 33 over over IN cord-005453-4057qib7 10985 34 a a DT cord-005453-4057qib7 10985 35 median median JJ cord-005453-4057qib7 10985 36 follow follow NN cord-005453-4057qib7 10985 37 - - HYPH cord-005453-4057qib7 10985 38 up up RP cord-005453-4057qib7 10985 39 time time NN cord-005453-4057qib7 10985 40 period period NN cord-005453-4057qib7 10985 41 of of IN cord-005453-4057qib7 10985 42 3.3 3.3 CD cord-005453-4057qib7 10985 43 years year NNS cord-005453-4057qib7 10985 44 . . . cord-005453-4057qib7 10986 1 Other other JJ cord-005453-4057qib7 10986 2 pretransplant pretransplant JJ cord-005453-4057qib7 10986 3 patient patient NN cord-005453-4057qib7 10986 4 and and CC cord-005453-4057qib7 10986 5 disease disease NN cord-005453-4057qib7 10986 6 characteristics characteristic NNS cord-005453-4057qib7 10986 7 did do VBD cord-005453-4057qib7 10986 8 not not RB cord-005453-4057qib7 10986 9 significantly significantly RB cord-005453-4057qib7 10986 10 influenced influence VBN cord-005453-4057qib7 10986 11 the the DT cord-005453-4057qib7 10986 12 outcomes outcome NNS cord-005453-4057qib7 10986 13 . . . cord-005453-4057qib7 10987 1 Conclusions conclusion NNS cord-005453-4057qib7 10987 2 : : : cord-005453-4057qib7 10988 1 In in IN cord-005453-4057qib7 10988 2 patients patient NNS cord-005453-4057qib7 10988 3 with with IN cord-005453-4057qib7 10988 4 R r NN cord-005453-4057qib7 10988 5 / / SYM cord-005453-4057qib7 10988 6 R r NN cord-005453-4057qib7 10988 7 DLBCL DLBCL NNP cord-005453-4057qib7 10988 8 undergoing undergo VBG cord-005453-4057qib7 10988 9 auto auto NN cord-005453-4057qib7 10988 10 - - HYPH cord-005453-4057qib7 10988 11 HCT hct NN cord-005453-4057qib7 10988 12 , , , cord-005453-4057qib7 10988 13 surveillance surveillance NN cord-005453-4057qib7 10988 14 PET PET NNP cord-005453-4057qib7 10988 15 / / SYM cord-005453-4057qib7 10988 16 CT CT NNP cord-005453-4057qib7 10988 17 at at IN cord-005453-4057qib7 10988 18 day day NN cord-005453-4057qib7 10988 19 100 100 CD cord-005453-4057qib7 10988 20 identified identify VBN cord-005453-4057qib7 10988 21 patients patient NNS cord-005453-4057qib7 10988 22 with with IN cord-005453-4057qib7 10988 23 poor poor JJ cord-005453-4057qib7 10988 24 survival~1 survival~1 NNP cord-005453-4057qib7 10988 25 year year NN cord-005453-4057qib7 10988 26 . . . cord-005453-4057qib7 10989 1 Higher high JJR cord-005453-4057qib7 10989 2 SUV SUV NNP cord-005453-4057qib7 10989 3 in in IN cord-005453-4057qib7 10989 4 both both DT cord-005453-4057qib7 10989 5 pre pre JJ cord-005453-4057qib7 10989 6 - - NN cord-005453-4057qib7 10989 7 transplant transplant NN cord-005453-4057qib7 10989 8 as as RB cord-005453-4057qib7 10989 9 well well RB cord-005453-4057qib7 10989 10 as as IN cord-005453-4057qib7 10989 11 post post JJ cord-005453-4057qib7 10989 12 - - JJ cord-005453-4057qib7 10989 13 HCT hct JJ cord-005453-4057qib7 10989 14 PET pet NN cord-005453-4057qib7 10989 15 was be VBD cord-005453-4057qib7 10989 16 predictive predictive JJ cord-005453-4057qib7 10989 17 of of IN cord-005453-4057qib7 10989 18 increased increase VBN cord-005453-4057qib7 10989 19 mortality mortality NN cord-005453-4057qib7 10989 20 . . . cord-005453-4057qib7 10990 1 These these DT cord-005453-4057qib7 10990 2 patients patient NNS cord-005453-4057qib7 10990 3 may may MD cord-005453-4057qib7 10990 4 benefit benefit VB cord-005453-4057qib7 10990 5 from from IN cord-005453-4057qib7 10990 6 novel novel JJ cord-005453-4057qib7 10990 7 treatments treatment NNS cord-005453-4057qib7 10990 8 . . . cord-005453-4057qib7 10991 1 [ [ -LRB- cord-005453-4057qib7 10991 2 There there EX cord-005453-4057qib7 10991 3 are be VBP cord-005453-4057qib7 10991 4 concerns concern NNS cord-005453-4057qib7 10991 5 about about IN cord-005453-4057qib7 10991 6 the the DT cord-005453-4057qib7 10991 7 risks risk NNS cord-005453-4057qib7 10991 8 of of IN cord-005453-4057qib7 10991 9 nivolumab nivolumab JJ cord-005453-4057qib7 10991 10 treatment treatment NN cord-005453-4057qib7 10991 11 before before RB cord-005453-4057qib7 10991 12 and and CC cord-005453-4057qib7 10991 13 after after IN cord-005453-4057qib7 10991 14 allo allo NN cord-005453-4057qib7 10991 15 - - HYPH cord-005453-4057qib7 10991 16 HSCT HSCT NNP cord-005453-4057qib7 10991 17 , , , cord-005453-4057qib7 10991 18 due due IN cord-005453-4057qib7 10991 19 to to IN cord-005453-4057qib7 10991 20 the the DT cord-005453-4057qib7 10991 21 risk risk NN cord-005453-4057qib7 10991 22 of of IN cord-005453-4057qib7 10991 23 heavy heavy JJ cord-005453-4057qib7 10991 24 GVHD GVHD NNP cord-005453-4057qib7 10991 25 , , , cord-005453-4057qib7 10991 26 thus thus RB cord-005453-4057qib7 10991 27 the the DT cord-005453-4057qib7 10991 28 place place NN cord-005453-4057qib7 10991 29 of of IN cord-005453-4057qib7 10991 30 immune immune JJ cord-005453-4057qib7 10991 31 checkpoints checkpoint NNS cord-005453-4057qib7 10991 32 inhibitors inhibitor NNS cord-005453-4057qib7 10991 33 is be VBZ cord-005453-4057qib7 10991 34 not not RB cord-005453-4057qib7 10991 35 yet yet RB cord-005453-4057qib7 10991 36 defined define VBN cord-005453-4057qib7 10991 37 . . . cord-005453-4057qib7 10992 1 This this DT cord-005453-4057qib7 10992 2 report report NN cord-005453-4057qib7 10992 3 include include VBP cord-005453-4057qib7 10992 4 analysis analysis NN cord-005453-4057qib7 10992 5 of of IN cord-005453-4057qib7 10992 6 our -PRON- PRP$ cord-005453-4057qib7 10992 7 center center NN cord-005453-4057qib7 10992 8 experience experience NN cord-005453-4057qib7 10992 9 of of IN cord-005453-4057qib7 10992 10 nivolumab nivolumab JJ cord-005453-4057qib7 10992 11 treatment treatment NN cord-005453-4057qib7 10992 12 in in IN cord-005453-4057qib7 10992 13 patients patient NNS cord-005453-4057qib7 10992 14 with with IN cord-005453-4057qib7 10992 15 r r NN cord-005453-4057qib7 10992 16 / / SYM cord-005453-4057qib7 10992 17 r r NN cord-005453-4057qib7 10992 18 HL HL NNP cord-005453-4057qib7 10992 19 before before RB cord-005453-4057qib7 10992 20 and and CC cord-005453-4057qib7 10992 21 after after IN cord-005453-4057qib7 10992 22 alloHSCT alloHSCT NNP cord-005453-4057qib7 10992 23 . . . cord-005453-4057qib7 10993 1 Methods method NNS cord-005453-4057qib7 10993 2 : : : cord-005453-4057qib7 10993 3 We -PRON- PRP cord-005453-4057qib7 10993 4 retrospectively retrospectively RB cord-005453-4057qib7 10993 5 evaluated evaluate VBD cord-005453-4057qib7 10993 6 the the DT cord-005453-4057qib7 10993 7 results result NNS cord-005453-4057qib7 10993 8 of of IN cord-005453-4057qib7 10993 9 alloHSCT allohsct NN cord-005453-4057qib7 10993 10 in in IN cord-005453-4057qib7 10993 11 86 86 CD cord-005453-4057qib7 10993 12 patients patient NNS cord-005453-4057qib7 10993 13 with with IN cord-005453-4057qib7 10993 14 r r NN cord-005453-4057qib7 10993 15 / / SYM cord-005453-4057qib7 10993 16 r r NN cord-005453-4057qib7 10993 17 cHL chl NN cord-005453-4057qib7 10993 18 who who WP cord-005453-4057qib7 10993 19 had have VBD cord-005453-4057qib7 10993 20 undergone undergo VBN cord-005453-4057qib7 10993 21 transplant transplant NN cord-005453-4057qib7 10993 22 from from IN cord-005453-4057qib7 10993 23 2002 2002 CD cord-005453-4057qib7 10993 24 to to IN cord-005453-4057qib7 10993 25 2018 2018 CD cord-005453-4057qib7 10993 26 . . . cord-005453-4057qib7 10994 1 The the DT cord-005453-4057qib7 10994 2 analysis analysis NN cord-005453-4057qib7 10994 3 included include VBD cord-005453-4057qib7 10994 4 patients patient NNS cord-005453-4057qib7 10994 5 received receive VBD cord-005453-4057qib7 10994 6 the the DT cord-005453-4057qib7 10994 7 FluBe flube NN cord-005453-4057qib7 10994 8 conditioning conditioning NN cord-005453-4057qib7 10994 9 and and CC cord-005453-4057qib7 10994 10 PTCy PTCy NNS cord-005453-4057qib7 10994 11 GVHD GVHD NNP cord-005453-4057qib7 10994 12 prophylaxis prophylaxis NN cord-005453-4057qib7 10994 13 . . . cord-005453-4057qib7 10995 1 In in IN cord-005453-4057qib7 10995 2 group group NN cord-005453-4057qib7 10995 3 A a DT cord-005453-4057qib7 10995 4 patients patient NNS cord-005453-4057qib7 10995 5 ( ( -LRB- cord-005453-4057qib7 10995 6 n=20 n=20 NN cord-005453-4057qib7 10995 7 ) ) -RRB- cord-005453-4057qib7 10995 8 received receive VBD cord-005453-4057qib7 10995 9 bridge bridge NN cord-005453-4057qib7 10995 10 therapy therapy NN cord-005453-4057qib7 10995 11 with with IN cord-005453-4057qib7 10995 12 Nivоlumab Nivоlumab NNP cord-005453-4057qib7 10995 13 and and CC cord-005453-4057qib7 10995 14 in in IN cord-005453-4057qib7 10995 15 group group NN cord-005453-4057qib7 10995 16 B b NN cord-005453-4057qib7 10995 17 patients patient NNS cord-005453-4057qib7 10995 18 ( ( -LRB- cord-005453-4057qib7 10995 19 n=34 n=34 NNP cord-005453-4057qib7 10995 20 ) ) -RRB- cord-005453-4057qib7 10995 21 received receive VBD cord-005453-4057qib7 10995 22 bridge bridge NN cord-005453-4057qib7 10995 23 therapy therapy NN cord-005453-4057qib7 10995 24 with with IN cord-005453-4057qib7 10995 25 Brentuximab Brentuximab NNP cord-005453-4057qib7 10995 26 vedotin vedotin NNP cord-005453-4057qib7 10995 27 or or CC cord-005453-4057qib7 10995 28 chemotherapy chemotherapy NN cord-005453-4057qib7 10995 29 - - HYPH cord-005453-4057qib7 10995 30 based base VBN cord-005453-4057qib7 10995 31 bridges bridge NNS cord-005453-4057qib7 10995 32 . . . cord-005453-4057qib7 10996 1 Time time NN cord-005453-4057qib7 10996 2 from from IN cord-005453-4057qib7 10996 3 the the DT cord-005453-4057qib7 10996 4 last last JJ cord-005453-4057qib7 10996 5 Nivolumab Nivolumab NNP cord-005453-4057qib7 10996 6 administration administration NN cord-005453-4057qib7 10996 7 to to IN cord-005453-4057qib7 10996 8 alloHSCT alloHSCT NNP cord-005453-4057qib7 10996 9 was be VBD cord-005453-4057qib7 10996 10 at at IN cord-005453-4057qib7 10996 11 least least JJS cord-005453-4057qib7 10996 12 2 2 CD cord-005453-4057qib7 10996 13 months month NNS cord-005453-4057qib7 10996 14 . . . cord-005453-4057qib7 10997 1 Results result NNS cord-005453-4057qib7 10997 2 : : : cord-005453-4057qib7 10998 1 At at IN cord-005453-4057qib7 10998 2 the the DT cord-005453-4057qib7 10998 3 time time NN cord-005453-4057qib7 10998 4 of of IN cord-005453-4057qib7 10998 5 analysis analysis NN cord-005453-4057qib7 10998 6 , , , cord-005453-4057qib7 10998 7 median median JJ cord-005453-4057qib7 10998 8 follow follow NN cord-005453-4057qib7 10998 9 - - HYPH cord-005453-4057qib7 10998 10 up up NN cord-005453-4057qib7 10998 11 was be VBD cord-005453-4057qib7 10998 12 12 12 CD cord-005453-4057qib7 10998 13 ( ( -LRB- cord-005453-4057qib7 10998 14 1 1 CD cord-005453-4057qib7 10998 15 - - SYM cord-005453-4057qib7 10998 16 20 20 CD cord-005453-4057qib7 10998 17 ) ) -RRB- cord-005453-4057qib7 10998 18 months month NNS cord-005453-4057qib7 10998 19 for for IN cord-005453-4057qib7 10998 20 group group NN cord-005453-4057qib7 10998 21 A A NNP cord-005453-4057qib7 10998 22 , , , cord-005453-4057qib7 10998 23 and and CC cord-005453-4057qib7 10998 24 15 15 CD cord-005453-4057qib7 10998 25 ( ( -LRB- cord-005453-4057qib7 10998 26 1 1 CD cord-005453-4057qib7 10998 27 - - SYM cord-005453-4057qib7 10998 28 64 64 CD cord-005453-4057qib7 10998 29 ) ) -RRB- cord-005453-4057qib7 10998 30 months month NNS cord-005453-4057qib7 10998 31 for for IN cord-005453-4057qib7 10998 32 group group NN cord-005453-4057qib7 10999 1 B. B. NNP cord-005453-4057qib7 10999 2 There there EX cord-005453-4057qib7 10999 3 was be VBD cord-005453-4057qib7 10999 4 no no DT cord-005453-4057qib7 10999 5 difference difference NN cord-005453-4057qib7 10999 6 in in IN cord-005453-4057qib7 10999 7 two two CD cord-005453-4057qib7 10999 8 - - HYPH cord-005453-4057qib7 10999 9 year year NN cord-005453-4057qib7 10999 10 OS os NN cord-005453-4057qib7 10999 11 ( ( -LRB- cord-005453-4057qib7 10999 12 p=0,39 p=0,39 NNP cord-005453-4057qib7 10999 13 ) ) -RRB- cord-005453-4057qib7 10999 14 with with IN cord-005453-4057qib7 10999 15 significantly significantly RB cord-005453-4057qib7 10999 16 better well JJR cord-005453-4057qib7 10999 17 EFS EFS NNP cord-005453-4057qib7 10999 18 ( ( -LRB- cord-005453-4057qib7 10999 19 p=0,025 p=0,025 NNP cord-005453-4057qib7 10999 20 ) ) -RRB- cord-005453-4057qib7 10999 21 for for IN cord-005453-4057qib7 10999 22 group group NN cord-005453-4057qib7 10999 23 A A NNP cord-005453-4057qib7 10999 24 versus versus IN cord-005453-4057qib7 10999 25 group group NN cord-005453-4057qib7 10999 26 B b NN cord-005453-4057qib7 10999 27 : : : cord-005453-4057qib7 10999 28 95 95 CD cord-005453-4057qib7 10999 29 % % NN cord-005453-4057qib7 10999 30 and and CC cord-005453-4057qib7 10999 31 95 95 CD cord-005453-4057qib7 10999 32 % % NN cord-005453-4057qib7 10999 33 vs vs IN cord-005453-4057qib7 10999 34 85,3 85,3 CD cord-005453-4057qib7 10999 35 % % NN cord-005453-4057qib7 10999 36 and and CC cord-005453-4057qib7 10999 37 62 62 CD cord-005453-4057qib7 10999 38 % % NN cord-005453-4057qib7 10999 39 respectively respectively RB cord-005453-4057qib7 10999 40 . . . cord-005453-4057qib7 11000 1 Relapse relapse NN cord-005453-4057qib7 11000 2 incidence incidence NN cord-005453-4057qib7 11000 3 was be VBD cord-005453-4057qib7 11000 4 0 0 CD cord-005453-4057qib7 11000 5 % % NN cord-005453-4057qib7 11000 6 for for IN cord-005453-4057qib7 11000 7 group group NN cord-005453-4057qib7 11000 8 A A NNP cord-005453-4057qib7 11000 9 versus versus IN cord-005453-4057qib7 11000 10 26,5 26,5 CD cord-005453-4057qib7 11000 11 % % NN cord-005453-4057qib7 11000 12 in in IN cord-005453-4057qib7 11000 13 group group NN cord-005453-4057qib7 11000 14 B B NNP cord-005453-4057qib7 11000 15 ( ( -LRB- cord-005453-4057qib7 11000 16 p=0,025 p=0,025 NNP cord-005453-4057qib7 11000 17 ) ) -RRB- cord-005453-4057qib7 11000 18 . . . cord-005453-4057qib7 11001 1 Cumulative cumulative JJ cord-005453-4057qib7 11001 2 incidence incidence NN cord-005453-4057qib7 11001 3 of of IN cord-005453-4057qib7 11001 4 non non JJ cord-005453-4057qib7 11001 5 - - JJ cord-005453-4057qib7 11001 6 relapse relapse JJ cord-005453-4057qib7 11001 7 mortality mortality NN cord-005453-4057qib7 11001 8 at at IN cord-005453-4057qib7 11001 9 2 2 CD cord-005453-4057qib7 11001 10 years year NNS cord-005453-4057qib7 11001 11 was be VBD cord-005453-4057qib7 11001 12 5,0 5,0 CD cord-005453-4057qib7 11001 13 % % NN cord-005453-4057qib7 11001 14 and and CC cord-005453-4057qib7 11001 15 13,8 13,8 CD cord-005453-4057qib7 11001 16 % % NN cord-005453-4057qib7 11001 17 in in IN cord-005453-4057qib7 11001 18 group group NN cord-005453-4057qib7 11001 19 A a NN cord-005453-4057qib7 11001 20 and and CC cord-005453-4057qib7 11001 21 group group NN cord-005453-4057qib7 11001 22 B b NN cord-005453-4057qib7 11001 23 , , , cord-005453-4057qib7 11001 24 respectively respectively RB cord-005453-4057qib7 11001 25 ( ( -LRB- cord-005453-4057qib7 11001 26 p=0,631 p=0,631 NNP cord-005453-4057qib7 11001 27 ) ) -RRB- cord-005453-4057qib7 11001 28 . . . cord-005453-4057qib7 11002 1 There there EX cord-005453-4057qib7 11002 2 was be VBD cord-005453-4057qib7 11002 3 no no DT cord-005453-4057qib7 11002 4 difference difference NN cord-005453-4057qib7 11002 5 in in IN cord-005453-4057qib7 11002 6 grade grade NN cord-005453-4057qib7 11002 7 II II NNP cord-005453-4057qib7 11002 8 - - HYPH cord-005453-4057qib7 11002 9 IV IV NNP cord-005453-4057qib7 11002 10 ( ( -LRB- cord-005453-4057qib7 11002 11 44 44 CD cord-005453-4057qib7 11002 12 % % NN cord-005453-4057qib7 11002 13 vs vs IN cord-005453-4057qib7 11002 14 27 27 CD cord-005453-4057qib7 11002 15 % % NN cord-005453-4057qib7 11002 16 , , , cord-005453-4057qib7 11002 17 p=0.23 p=0.23 NNP cord-005453-4057qib7 11002 18 ) ) -RRB- cord-005453-4057qib7 11002 19 and and CC cord-005453-4057qib7 11002 20 grade grade NN cord-005453-4057qib7 11002 21 III III NNP cord-005453-4057qib7 11002 22 - - HYPH cord-005453-4057qib7 11002 23 IV IV NNP cord-005453-4057qib7 11002 24 ( ( -LRB- cord-005453-4057qib7 11002 25 22 22 CD cord-005453-4057qib7 11002 26 % % NN cord-005453-4057qib7 11002 27 vs vs IN cord-005453-4057qib7 11002 28 13 13 CD cord-005453-4057qib7 11002 29 % % NN cord-005453-4057qib7 11002 30 , , , cord-005453-4057qib7 11002 31 p=0.3 p=0.3 NNP cord-005453-4057qib7 11002 32 ) ) -RRB- cord-005453-4057qib7 11002 33 aGVHD aGVHD NNP cord-005453-4057qib7 11002 34 , , , cord-005453-4057qib7 11002 35 as as RB cord-005453-4057qib7 11002 36 well well RB cord-005453-4057qib7 11002 37 as as IN cord-005453-4057qib7 11002 38 extensive extensive JJ cord-005453-4057qib7 11002 39 chronic chronic JJ cord-005453-4057qib7 11002 40 GVHD GVHD NNP cord-005453-4057qib7 11002 41 ( ( -LRB- cord-005453-4057qib7 11002 42 21 21 CD cord-005453-4057qib7 11002 43 % % NN cord-005453-4057qib7 11002 44 vs vs IN cord-005453-4057qib7 11002 45 28 28 CD cord-005453-4057qib7 11002 46 % % NN cord-005453-4057qib7 11002 47 , , , cord-005453-4057qib7 11002 48 p=0,83 p=0,83 NNP cord-005453-4057qib7 11002 49 ) ) -RRB- cord-005453-4057qib7 11002 50 in in IN cord-005453-4057qib7 11002 51 groups group NNS cord-005453-4057qib7 11002 52 A A NNP cord-005453-4057qib7 11002 53 and and CC cord-005453-4057qib7 11002 54 B b NN cord-005453-4057qib7 11002 55 , , , cord-005453-4057qib7 11002 56 respectively respectively RB cord-005453-4057qib7 11002 57 . . . cord-005453-4057qib7 11003 1 Ten ten CD cord-005453-4057qib7 11003 2 patients patient NNS cord-005453-4057qib7 11003 3 with with IN cord-005453-4057qib7 11003 4 relapse relapse NN cord-005453-4057qib7 11003 5 after after IN cord-005453-4057qib7 11003 6 alloHSCT alloHSCT NNP cord-005453-4057qib7 11003 7 were be VBD cord-005453-4057qib7 11003 8 treated treat VBN cord-005453-4057qib7 11003 9 with with IN cord-005453-4057qib7 11003 10 different different JJ cord-005453-4057qib7 11003 11 doses dose NNS cord-005453-4057qib7 11003 12 ( ( -LRB- cord-005453-4057qib7 11003 13 0,5 0,5 CD cord-005453-4057qib7 11003 14 - - SYM cord-005453-4057qib7 11003 15 3 3 CD cord-005453-4057qib7 11003 16 mg mg NNP cord-005453-4057qib7 11003 17 / / SYM cord-005453-4057qib7 11003 18 kg kg NNP cord-005453-4057qib7 11003 19 ) ) -RRB- cord-005453-4057qib7 11003 20 of of IN cord-005453-4057qib7 11003 21 nivolumab nivolumab NNP cord-005453-4057qib7 11003 22 in in IN cord-005453-4057qib7 11003 23 CIC725 CIC725 NNP cord-005453-4057qib7 11003 24 center center NN cord-005453-4057qib7 11003 25 . . . cord-005453-4057qib7 11004 1 At at IN cord-005453-4057qib7 11004 2 the the DT cord-005453-4057qib7 11004 3 median median NN cord-005453-4057qib7 11004 4 follow follow NN cord-005453-4057qib7 11004 5 up up IN cord-005453-4057qib7 11004 6 of of IN cord-005453-4057qib7 11004 7 16 16 CD cord-005453-4057qib7 11004 8 mo mo NN cord-005453-4057qib7 11004 9 ( ( -LRB- cord-005453-4057qib7 11004 10 0,6 0,6 CD cord-005453-4057qib7 11004 11 - - SYM cord-005453-4057qib7 11004 12 28 28 CD cord-005453-4057qib7 11004 13 ) ) -RRB- cord-005453-4057qib7 11004 14 all all DT cord-005453-4057qib7 11004 15 patients patient NNS cord-005453-4057qib7 11004 16 remain remain VBP cord-005453-4057qib7 11004 17 alive alive JJ cord-005453-4057qib7 11004 18 . . . cord-005453-4057qib7 11005 1 The the DT cord-005453-4057qib7 11005 2 objective objective JJ cord-005453-4057qib7 11005 3 response response NN cord-005453-4057qib7 11005 4 to to IN cord-005453-4057qib7 11005 5 therapy therapy NN cord-005453-4057qib7 11005 6 was be VBD cord-005453-4057qib7 11005 7 assessed assess VBN cord-005453-4057qib7 11005 8 in in IN cord-005453-4057qib7 11005 9 7 7 CD cord-005453-4057qib7 11005 10 patients patient NNS cord-005453-4057qib7 11005 11 noted note VBN cord-005453-4057qib7 11005 12 in in IN cord-005453-4057qib7 11005 13 all all DT cord-005453-4057qib7 11005 14 patients patient NNS cord-005453-4057qib7 11005 15 ( ( -LRB- cord-005453-4057qib7 11005 16 100 100 CD cord-005453-4057qib7 11005 17 % % NN cord-005453-4057qib7 11005 18 ) ) -RRB- cord-005453-4057qib7 11005 19 , , , cord-005453-4057qib7 11005 20 disregard disregard VB cord-005453-4057qib7 11005 21 the the DT cord-005453-4057qib7 11005 22 dose dose NN cord-005453-4057qib7 11005 23 of of IN cord-005453-4057qib7 11005 24 the the DT cord-005453-4057qib7 11005 25 nivolumab nivolumab NNP cord-005453-4057qib7 11005 26 : : : cord-005453-4057qib7 11006 1 CR CR NNP cord-005453-4057qib7 11006 2 in in IN cord-005453-4057qib7 11006 3 29 29 CD cord-005453-4057qib7 11006 4 % % NN cord-005453-4057qib7 11006 5 , , , cord-005453-4057qib7 11006 6 and and CC cord-005453-4057qib7 11006 7 PR PR NNP cord-005453-4057qib7 11006 8 in in IN cord-005453-4057qib7 11006 9 71 71 CD cord-005453-4057qib7 11006 10 % % NN cord-005453-4057qib7 11006 11 . . . cord-005453-4057qib7 11007 1 The the DT cord-005453-4057qib7 11007 2 response response NN cord-005453-4057qib7 11007 3 was be VBD cord-005453-4057qib7 11007 4 lost lose VBN cord-005453-4057qib7 11007 5 in in IN cord-005453-4057qib7 11007 6 four four CD cord-005453-4057qib7 11007 7 patients patient NNS cord-005453-4057qib7 11007 8 , , , cord-005453-4057qib7 11007 9 which which WDT cord-005453-4057qib7 11007 10 required require VBD cord-005453-4057qib7 11007 11 nivolumab nivolumab NNP cord-005453-4057qib7 11007 12 retreatment retreatment NN cord-005453-4057qib7 11007 13 . . . cord-005453-4057qib7 11008 1 None none NN cord-005453-4057qib7 11008 2 of of IN cord-005453-4057qib7 11008 3 the the DT cord-005453-4057qib7 11008 4 patients patient NNS cord-005453-4057qib7 11008 5 developed develop VBD cord-005453-4057qib7 11008 6 GVHD GVHD NNP cord-005453-4057qib7 11008 7 after after IN cord-005453-4057qib7 11008 8 nivolumab nivolumab NNP cord-005453-4057qib7 11008 9 administration administration NN cord-005453-4057qib7 11008 10 . . . cord-005453-4057qib7 11009 1 In in IN cord-005453-4057qib7 11009 2 this this DT cord-005453-4057qib7 11009 3 analysis analysis NN cord-005453-4057qib7 11009 4 , , , cord-005453-4057qib7 11009 5 there there EX cord-005453-4057qib7 11009 6 was be VBD cord-005453-4057qib7 11009 7 also also RB cord-005453-4057qib7 11009 8 no no DT cord-005453-4057qib7 11009 9 correlation correlation NN cord-005453-4057qib7 11009 10 between between IN cord-005453-4057qib7 11009 11 dose dose NN cord-005453-4057qib7 11009 12 of of IN cord-005453-4057qib7 11009 13 nivolumab nivolumab NNS cord-005453-4057qib7 11009 14 and and CC cord-005453-4057qib7 11009 15 incidence incidence NN cord-005453-4057qib7 11009 16 and and CC cord-005453-4057qib7 11009 17 severity severity NN cord-005453-4057qib7 11009 18 of of IN cord-005453-4057qib7 11009 19 adverse adverse JJ cord-005453-4057qib7 11009 20 events event NNS cord-005453-4057qib7 11009 21 . . . cord-005453-4057qib7 11010 1 Conclusions conclusion NNS cord-005453-4057qib7 11010 2 : : : cord-005453-4057qib7 11010 3 AlloHSCT AlloHSCT NNP cord-005453-4057qib7 11010 4 in in IN cord-005453-4057qib7 11010 5 combination combination NN cord-005453-4057qib7 11010 6 with with IN cord-005453-4057qib7 11010 7 immune immune JJ cord-005453-4057qib7 11010 8 checkpoints checkpoint NNS cord-005453-4057qib7 11011 1 inhibitors inhibitor NNS cord-005453-4057qib7 11011 2 is be VBZ cord-005453-4057qib7 11011 3 a a DT cord-005453-4057qib7 11011 4 good good JJ cord-005453-4057qib7 11011 5 option option NN cord-005453-4057qib7 11011 6 for for IN cord-005453-4057qib7 11011 7 patients patient NNS cord-005453-4057qib7 11011 8 with with IN cord-005453-4057qib7 11011 9 r r NN cord-005453-4057qib7 11011 10 / / SYM cord-005453-4057qib7 11011 11 r r NN cord-005453-4057qib7 11011 12 cHL chl NN cord-005453-4057qib7 11011 13 . . . cord-005453-4057qib7 11012 1 Consideration consideration NN cord-005453-4057qib7 11012 2 for for IN cord-005453-4057qib7 11012 3 immune immune NN cord-005453-4057qib7 11012 4 - - HYPH cord-005453-4057qib7 11012 5 mediated mediate VBN cord-005453-4057qib7 11012 6 toxicities toxicity NNS cord-005453-4057qib7 11012 7 and and CC cord-005453-4057qib7 11012 8 the the DT cord-005453-4057qib7 11012 9 potential potential NN cord-005453-4057qib7 11012 10 for for IN cord-005453-4057qib7 11012 11 increased increase VBN cord-005453-4057qib7 11012 12 graft graft NN cord-005453-4057qib7 11012 13 - - HYPH cord-005453-4057qib7 11012 14 versus versus IN cord-005453-4057qib7 11012 15 - - HYPH cord-005453-4057qib7 11012 16 host host NN cord-005453-4057qib7 11012 17 disease disease NN cord-005453-4057qib7 11012 18 remain remain VBP cord-005453-4057qib7 11012 19 important important JJ cord-005453-4057qib7 11012 20 . . . cord-005453-4057qib7 11013 1 Early early JJ cord-005453-4057qib7 11013 2 data datum NNS cord-005453-4057qib7 11013 3 suggest suggest VBP cord-005453-4057qib7 11013 4 that that IN cord-005453-4057qib7 11013 5 nivolumab nivolumab NNP cord-005453-4057qib7 11013 6 may may MD cord-005453-4057qib7 11013 7 be be VB cord-005453-4057qib7 11013 8 an an DT cord-005453-4057qib7 11013 9 efficient efficient JJ cord-005453-4057qib7 11013 10 therapy therapy NN cord-005453-4057qib7 11013 11 in in IN cord-005453-4057qib7 11013 12 patients patient NNS cord-005453-4057qib7 11013 13 with with IN cord-005453-4057qib7 11013 14 r r NN cord-005453-4057qib7 11013 15 / / SYM cord-005453-4057qib7 11013 16 r r NN cord-005453-4057qib7 11013 17 cHL chl NN cord-005453-4057qib7 11013 18 relapse relapse NN cord-005453-4057qib7 11013 19 after after IN cord-005453-4057qib7 11013 20 allo allo NN cord-005453-4057qib7 11013 21 - - HYPH cord-005453-4057qib7 11013 22 HSCT HSCT NNP cord-005453-4057qib7 11013 23 . . . cord-005453-4057qib7 11014 1 Further further JJ cord-005453-4057qib7 11014 2 research research NN cord-005453-4057qib7 11014 3 needed need VBN cord-005453-4057qib7 11014 4 . . . cord-005453-4057qib7 11015 1 Disclosure disclosure NN cord-005453-4057qib7 11015 2 : : : cord-005453-4057qib7 11016 1 The the DT cord-005453-4057qib7 11016 2 authors author NNS cord-005453-4057qib7 11016 3 declare declare VBP cord-005453-4057qib7 11016 4 no no DT cord-005453-4057qib7 11016 5 conflicts conflict NNS cord-005453-4057qib7 11016 6 of of IN cord-005453-4057qib7 11016 7 interest interest NN cord-005453-4057qib7 11016 8 . . . cord-005453-4057qib7 11017 1 Background background NN cord-005453-4057qib7 11017 2 : : : cord-005453-4057qib7 11018 1 Transformation transformation NN cord-005453-4057qib7 11018 2 to to TO cord-005453-4057qib7 11018 3 diffuse diffuse VB cord-005453-4057qib7 11018 4 large large JJ cord-005453-4057qib7 11018 5 B b NN cord-005453-4057qib7 11018 6 - - HYPH cord-005453-4057qib7 11018 7 cell cell NN cord-005453-4057qib7 11018 8 lymphoma lymphoma NN cord-005453-4057qib7 11018 9 ( ( -LRB- cord-005453-4057qib7 11018 10 DLBCL DLBCL NNP cord-005453-4057qib7 11018 11 ) ) -RRB- cord-005453-4057qib7 11018 12 is be VBZ cord-005453-4057qib7 11018 13 considered consider VBN cord-005453-4057qib7 11018 14 to to TO cord-005453-4057qib7 11018 15 be be VB cord-005453-4057qib7 11018 16 one one CD cord-005453-4057qib7 11018 17 of of IN cord-005453-4057qib7 11018 18 the the DT cord-005453-4057qib7 11018 19 most most RBS cord-005453-4057qib7 11018 20 unfavourable unfavourable JJ cord-005453-4057qib7 11018 21 events event NNS cord-005453-4057qib7 11018 22 of of IN cord-005453-4057qib7 11018 23 lymphoma lymphoma NN cord-005453-4057qib7 11018 24 natural natural JJ cord-005453-4057qib7 11018 25 history history NN cord-005453-4057qib7 11018 26 with with IN cord-005453-4057qib7 11018 27 poorer poor JJR cord-005453-4057qib7 11018 28 outcome outcome NN cord-005453-4057qib7 11018 29 as as IN cord-005453-4057qib7 11018 30 compared compare VBN cord-005453-4057qib7 11018 31 to to IN cord-005453-4057qib7 11018 32 de de NNP cord-005453-4057qib7 11018 33 novo novo NNP cord-005453-4057qib7 11018 34 DLBCL DLBCL NNP cord-005453-4057qib7 11018 35 ( ( -LRB- cord-005453-4057qib7 11018 36 Alonso Alonso NNP cord-005453-4057qib7 11018 37 - - HYPH cord-005453-4057qib7 11018 38 Álvarez Álvarez NNP cord-005453-4057qib7 11018 39 et et FW cord-005453-4057qib7 11018 40 al al NNP cord-005453-4057qib7 11018 41 , , , cord-005453-4057qib7 11018 42 BJH BJH NNP cord-005453-4057qib7 11018 43 2017 2017 CD cord-005453-4057qib7 11018 44 ) ) -RRB- cord-005453-4057qib7 11018 45 . . . cord-005453-4057qib7 11019 1 In in IN cord-005453-4057qib7 11019 2 patients patient NNS cord-005453-4057qib7 11019 3 suitable suitable JJ cord-005453-4057qib7 11019 4 for for IN cord-005453-4057qib7 11019 5 salvage salvage NN cord-005453-4057qib7 11019 6 therapy therapy NN cord-005453-4057qib7 11019 7 , , , cord-005453-4057qib7 11019 8 hematopoietic hematopoietic JJ cord-005453-4057qib7 11019 9 stem stem NN cord-005453-4057qib7 11019 10 - - HYPH cord-005453-4057qib7 11019 11 cell cell NN cord-005453-4057qib7 11019 12 transplantation transplantation NN cord-005453-4057qib7 11019 13 ( ( -LRB- cord-005453-4057qib7 11019 14 SCT SCT NNP cord-005453-4057qib7 11019 15 ) ) -RRB- cord-005453-4057qib7 11019 16 could could MD cord-005453-4057qib7 11019 17 be be VB cord-005453-4057qib7 11019 18 an an DT cord-005453-4057qib7 11019 19 option option NN cord-005453-4057qib7 11019 20 , , , cord-005453-4057qib7 11019 21 although although IN cord-005453-4057qib7 11019 22 its -PRON- PRP$ cord-005453-4057qib7 11019 23 role role NN cord-005453-4057qib7 11019 24 is be VBZ cord-005453-4057qib7 11019 25 not not RB cord-005453-4057qib7 11019 26 well well RB cord-005453-4057qib7 11019 27 stablished stablishe VBN cord-005453-4057qib7 11019 28 . . . cord-005453-4057qib7 11020 1 We -PRON- PRP cord-005453-4057qib7 11020 2 analyse analyse VBP cord-005453-4057qib7 11020 3 indication indication NN cord-005453-4057qib7 11020 4 and and CC cord-005453-4057qib7 11020 5 outcome outcome NN cord-005453-4057qib7 11020 6 after after IN cord-005453-4057qib7 11020 7 transplant transplant NN cord-005453-4057qib7 11020 8 in in IN cord-005453-4057qib7 11020 9 transformed transform VBN cord-005453-4057qib7 11020 10 DLBCL DLBCL NNP cord-005453-4057qib7 11020 11 at at IN cord-005453-4057qib7 11020 12 a a DT cord-005453-4057qib7 11020 13 single single JJ cord-005453-4057qib7 11020 14 Reference reference NN cord-005453-4057qib7 11020 15 Transplant Transplant NNP cord-005453-4057qib7 11020 16 Unit Unit NNP cord-005453-4057qib7 11020 17 . . . cord-005453-4057qib7 11021 1 Methods method NNS cord-005453-4057qib7 11021 2 : : : cord-005453-4057qib7 11022 1 Out out IN cord-005453-4057qib7 11022 2 of of IN cord-005453-4057qib7 11022 3 2565 2565 CD cord-005453-4057qib7 11022 4 total total NN cord-005453-4057qib7 11022 5 of of IN cord-005453-4057qib7 11022 6 transplants transplant NNS cord-005453-4057qib7 11022 7 performed perform VBN cord-005453-4057qib7 11022 8 at at IN cord-005453-4057qib7 11022 9 our -PRON- PRP$ cord-005453-4057qib7 11022 10 Unit Unit NNP cord-005453-4057qib7 11022 11 between between IN cord-005453-4057qib7 11022 12 1995 1995 CD cord-005453-4057qib7 11022 13 and and CC cord-005453-4057qib7 11022 14 2018 2018 CD cord-005453-4057qib7 11022 15 -1564 -1564 VBP cord-005453-4057qib7 11022 16 autologous autologous JJ cord-005453-4057qib7 11022 17 and and CC cord-005453-4057qib7 11022 18 1001 1001 CD cord-005453-4057qib7 11022 19 allogeneic-51 allogeneic-51 CD cord-005453-4057qib7 11022 20 were be VBD cord-005453-4057qib7 11022 21 DLBCL dlbcl RB cord-005453-4057qib7 11022 22 transformed transform VBN cord-005453-4057qib7 11022 23 from from IN cord-005453-4057qib7 11022 24 an an DT cord-005453-4057qib7 11022 25 indolent indolent JJ cord-005453-4057qib7 11022 26 NHL NHL NNP cord-005453-4057qib7 11022 27 . . . cord-005453-4057qib7 11023 1 Of of IN cord-005453-4057qib7 11023 2 them -PRON- PRP cord-005453-4057qib7 11023 3 , , , cord-005453-4057qib7 11023 4 36 36 CD cord-005453-4057qib7 11023 5 received receive VBD cord-005453-4057qib7 11023 6 an an DT cord-005453-4057qib7 11023 7 autologous autologous JJ cord-005453-4057qib7 11023 8 SCT SCT NNP cord-005453-4057qib7 11023 9 ( ( -LRB- cord-005453-4057qib7 11023 10 ASCT ASCT NNP cord-005453-4057qib7 11023 11 ) ) -RRB- cord-005453-4057qib7 11023 12 and and CC cord-005453-4057qib7 11023 13 15 15 CD cord-005453-4057qib7 11023 14 an an DT cord-005453-4057qib7 11023 15 allogeneic allogeneic NN cord-005453-4057qib7 11023 16 SCT sct NN cord-005453-4057qib7 11023 17 ( ( -LRB- cord-005453-4057qib7 11023 18 allo allo NN cord-005453-4057qib7 11023 19 - - HYPH cord-005453-4057qib7 11023 20 SCT SCT NNP cord-005453-4057qib7 11023 21 ) ) -RRB- cord-005453-4057qib7 11023 22 . . . cord-005453-4057qib7 11024 1 Results result NNS cord-005453-4057qib7 11024 2 : : : cord-005453-4057qib7 11025 1 Median median JJ cord-005453-4057qib7 11025 2 age age NN cord-005453-4057qib7 11025 3 was be VBD cord-005453-4057qib7 11025 4 60 60 CD cord-005453-4057qib7 11025 5 years year NNS cord-005453-4057qib7 11025 6 old old JJ cord-005453-4057qib7 11025 7 ( ( -LRB- cord-005453-4057qib7 11025 8 range range VBP cord-005453-4057qib7 11025 9 40 40 CD cord-005453-4057qib7 11025 10 - - SYM cord-005453-4057qib7 11025 11 69 69 CD cord-005453-4057qib7 11025 12 ) ) -RRB- cord-005453-4057qib7 11025 13 and and CC cord-005453-4057qib7 11025 14 52 52 CD cord-005453-4057qib7 11025 15 ( ( -LRB- cord-005453-4057qib7 11025 16 range range NN cord-005453-4057qib7 11025 17 35 35 CD cord-005453-4057qib7 11025 18 - - SYM cord-005453-4057qib7 11025 19 65 65 CD cord-005453-4057qib7 11025 20 ) ) -RRB- cord-005453-4057qib7 11025 21 for for IN cord-005453-4057qib7 11025 22 patients patient NNS cord-005453-4057qib7 11025 23 receiving receive VBG cord-005453-4057qib7 11025 24 ASCT ASCT NNP cord-005453-4057qib7 11025 25 and and CC cord-005453-4057qib7 11025 26 allo allo NN cord-005453-4057qib7 11025 27 - - HYPH cord-005453-4057qib7 11025 28 SCT SCT NNP cord-005453-4057qib7 11025 29 , , , cord-005453-4057qib7 11025 30 respectively respectively RB cord-005453-4057qib7 11025 31 . . . cord-005453-4057qib7 11026 1 All all DT cord-005453-4057qib7 11026 2 ASCT ASCT NNP cord-005453-4057qib7 11026 3 received receive VBD cord-005453-4057qib7 11026 4 BEAM BEAM NNP cord-005453-4057qib7 11026 5 as as IN cord-005453-4057qib7 11026 6 a a DT cord-005453-4057qib7 11026 7 conditioning conditioning NN cord-005453-4057qib7 11026 8 regimen regimen NN cord-005453-4057qib7 11026 9 and and CC cord-005453-4057qib7 11026 10 most most JJS cord-005453-4057qib7 11026 11 of of IN cord-005453-4057qib7 11026 12 the the DT cord-005453-4057qib7 11026 13 patients patient NNS cord-005453-4057qib7 11026 14 in in IN cord-005453-4057qib7 11026 15 the the DT cord-005453-4057qib7 11026 16 allo allo NNP cord-005453-4057qib7 11026 17 - - HYPH cord-005453-4057qib7 11026 18 SCT SCT NNP cord-005453-4057qib7 11026 19 group group NN cord-005453-4057qib7 11026 20 received receive VBD cord-005453-4057qib7 11026 21 a a DT cord-005453-4057qib7 11026 22 fludarabine fludarabine NN cord-005453-4057qib7 11026 23 / / SYM cord-005453-4057qib7 11026 24 melphalan melphalan NN cord-005453-4057qib7 11026 25 combination combination NN cord-005453-4057qib7 11026 26 ( ( -LRB- cord-005453-4057qib7 11026 27 73 73 CD cord-005453-4057qib7 11026 28 % % NN cord-005453-4057qib7 11026 29 ) ) -RRB- cord-005453-4057qib7 11026 30 . . . cord-005453-4057qib7 11027 1 GVHD GVHD NNP cord-005453-4057qib7 11027 2 prophylaxis prophylaxis NN cord-005453-4057qib7 11027 3 consisted consist VBD cord-005453-4057qib7 11027 4 on on IN cord-005453-4057qib7 11027 5 tacrolimus tacrolimus NNP cord-005453-4057qib7 11027 6 / / SYM cord-005453-4057qib7 11027 7 sirolimus sirolimus NN cord-005453-4057qib7 11027 8 combination combination NN cord-005453-4057qib7 11027 9 in in IN cord-005453-4057qib7 11027 10 87 87 CD cord-005453-4057qib7 11027 11 % % NN cord-005453-4057qib7 11027 12 and and CC cord-005453-4057qib7 11027 13 calcioneurin calcioneurin NNP cord-005453-4057qib7 11027 14 plus plus CC cord-005453-4057qib7 11027 15 methotrexate methotrexate NNP cord-005453-4057qib7 11027 16 in in IN cord-005453-4057qib7 11027 17 13 13 CD cord-005453-4057qib7 11027 18 % % NN cord-005453-4057qib7 11027 19 . . . cord-005453-4057qib7 11028 1 Regarding regard VBG cord-005453-4057qib7 11028 2 transplant transplant NN cord-005453-4057qib7 11028 3 disease disease NN cord-005453-4057qib7 11028 4 status status NN cord-005453-4057qib7 11028 5 , , , cord-005453-4057qib7 11028 6 28 28 CD cord-005453-4057qib7 11028 7 ( ( -LRB- cord-005453-4057qib7 11028 8 78 78 CD cord-005453-4057qib7 11028 9 % % NN cord-005453-4057qib7 11028 10 ) ) -RRB- cord-005453-4057qib7 11028 11 of of IN cord-005453-4057qib7 11028 12 the the DT cord-005453-4057qib7 11028 13 ASCT ASCT NNP cord-005453-4057qib7 11028 14 patients patient NNS cord-005453-4057qib7 11028 15 were be VBD cord-005453-4057qib7 11028 16 transplanted transplant VBN cord-005453-4057qib7 11028 17 in in IN cord-005453-4057qib7 11028 18 complete complete JJ cord-005453-4057qib7 11028 19 response response NN cord-005453-4057qib7 11028 20 ( ( -LRB- cord-005453-4057qib7 11028 21 CR CR NNP cord-005453-4057qib7 11028 22 ) ) -RRB- cord-005453-4057qib7 11028 23 . . . cord-005453-4057qib7 11029 1 In in IN cord-005453-4057qib7 11029 2 the the DT cord-005453-4057qib7 11029 3 allo allo NNP cord-005453-4057qib7 11029 4 - - HYPH cord-005453-4057qib7 11029 5 SCT SCT NNP cord-005453-4057qib7 11029 6 group group NN cord-005453-4057qib7 11029 7 , , , cord-005453-4057qib7 11029 8 11 11 CD cord-005453-4057qib7 11029 9 ( ( -LRB- cord-005453-4057qib7 11029 10 73 73 CD cord-005453-4057qib7 11029 11 % % NN cord-005453-4057qib7 11029 12 ) ) -RRB- cord-005453-4057qib7 11029 13 patients patient NNS cord-005453-4057qib7 11029 14 had have VBD cord-005453-4057qib7 11029 15 received receive VBN cord-005453-4057qib7 11029 16 three three CD cord-005453-4057qib7 11029 17 or or CC cord-005453-4057qib7 11029 18 more more JJR cord-005453-4057qib7 11029 19 treatment treatment NN cord-005453-4057qib7 11029 20 lines line NNS cord-005453-4057qib7 11029 21 before before IN cord-005453-4057qib7 11029 22 transplant transplant NN cord-005453-4057qib7 11029 23 and and CC cord-005453-4057qib7 11029 24 13 13 CD cord-005453-4057qib7 11029 25 patients patient NNS cord-005453-4057qib7 11029 26 ( ( -LRB- cord-005453-4057qib7 11029 27 87 87 CD cord-005453-4057qib7 11029 28 % % NN cord-005453-4057qib7 11029 29 ) ) -RRB- cord-005453-4057qib7 11029 30 had have VBD cord-005453-4057qib7 11029 31 received receive VBN cord-005453-4057qib7 11029 32 a a DT cord-005453-4057qib7 11029 33 previous previous JJ cord-005453-4057qib7 11029 34 ASCT ASCT NNP cord-005453-4057qib7 11029 35 , , , cord-005453-4057qib7 11029 36 being be VBG cord-005453-4057qib7 11029 37 11 11 CD cord-005453-4057qib7 11029 38 ( ( -LRB- cord-005453-4057qib7 11029 39 73 73 CD cord-005453-4057qib7 11029 40 % % NN cord-005453-4057qib7 11029 41 ) ) -RRB- cord-005453-4057qib7 11029 42 in in IN cord-005453-4057qib7 11029 43 CR CR NNP cord-005453-4057qib7 11029 44 , , , cord-005453-4057qib7 11029 45 3 3 CD cord-005453-4057qib7 11029 46 in in IN cord-005453-4057qib7 11029 47 partial partial JJ cord-005453-4057qib7 11029 48 response response NN cord-005453-4057qib7 11029 49 ( ( -LRB- cord-005453-4057qib7 11029 50 PR PR NNP cord-005453-4057qib7 11029 51 ) ) -RRB- cord-005453-4057qib7 11029 52 and and CC cord-005453-4057qib7 11029 53 1 1 CD cord-005453-4057qib7 11029 54 in in IN cord-005453-4057qib7 11029 55 progressive progressive JJ cord-005453-4057qib7 11029 56 disease disease NN cord-005453-4057qib7 11029 57 . . . cord-005453-4057qib7 11030 1 Transplant transplant NN cord-005453-4057qib7 11030 2 related relate VBN cord-005453-4057qib7 11030 3 mortality mortality NN cord-005453-4057qib7 11030 4 ( ( -LRB- cord-005453-4057qib7 11030 5 TRM TRM NNP cord-005453-4057qib7 11030 6 ) ) -RRB- cord-005453-4057qib7 11030 7 was be VBD cord-005453-4057qib7 11030 8 5.6 5.6 CD cord-005453-4057qib7 11030 9 % % NN cord-005453-4057qib7 11030 10 in in IN cord-005453-4057qib7 11030 11 the the DT cord-005453-4057qib7 11030 12 ASCT ASCT NNP cord-005453-4057qib7 11030 13 and and CC cord-005453-4057qib7 11030 14 27 27 CD cord-005453-4057qib7 11030 15 % % NN cord-005453-4057qib7 11031 1 In in IN cord-005453-4057qib7 11031 2 the the DT cord-005453-4057qib7 11031 3 allo allo NNP cord-005453-4057qib7 11031 4 - - HYPH cord-005453-4057qib7 11031 5 SCT sct NN cord-005453-4057qib7 11031 6 group group NN cord-005453-4057qib7 11031 7 . . . cord-005453-4057qib7 11032 1 Overall overall JJ cord-005453-4057qib7 11032 2 survival survival NN cord-005453-4057qib7 11032 3 ( ( -LRB- cord-005453-4057qib7 11032 4 OS OS NNP cord-005453-4057qib7 11032 5 ) ) -RRB- cord-005453-4057qib7 11032 6 and and CC cord-005453-4057qib7 11032 7 progression progression NN cord-005453-4057qib7 11032 8 - - HYPH cord-005453-4057qib7 11032 9 free free JJ cord-005453-4057qib7 11032 10 - - HYPH cord-005453-4057qib7 11032 11 survival survival NN cord-005453-4057qib7 11032 12 ( ( -LRB- cord-005453-4057qib7 11032 13 PFS PFS NNP cord-005453-4057qib7 11032 14 ) ) -RRB- cord-005453-4057qib7 11032 15 at at IN cord-005453-4057qib7 11032 16 25 25 CD cord-005453-4057qib7 11032 17 months month NNS cord-005453-4057qib7 11032 18 were be VBD cord-005453-4057qib7 11032 19 94 94 CD cord-005453-4057qib7 11032 20 % % NN cord-005453-4057qib7 11032 21 ( ( -LRB- cord-005453-4057qib7 11032 22 OS OS NNP cord-005453-4057qib7 11032 23 ) ) -RRB- cord-005453-4057qib7 11032 24 , , , cord-005453-4057qib7 11032 25 76 76 CD cord-005453-4057qib7 11032 26 % % NN cord-005453-4057qib7 11032 27 ( ( -LRB- cord-005453-4057qib7 11032 28 PFS PFS NNP cord-005453-4057qib7 11032 29 ) ) -RRB- cord-005453-4057qib7 11032 30 for for IN cord-005453-4057qib7 11032 31 patients patient NNS cord-005453-4057qib7 11032 32 receiving receive VBG cord-005453-4057qib7 11032 33 ASCT ASCT NNP cord-005453-4057qib7 11032 34 and and CC cord-005453-4057qib7 11032 35 63 63 CD cord-005453-4057qib7 11032 36 % % NN cord-005453-4057qib7 11032 37 ( ( -LRB- cord-005453-4057qib7 11032 38 OS OS NNP cord-005453-4057qib7 11032 39 ) ) -RRB- cord-005453-4057qib7 11032 40 and and CC cord-005453-4057qib7 11032 41 56 56 CD cord-005453-4057qib7 11032 42 % % NN cord-005453-4057qib7 11032 43 ( ( -LRB- cord-005453-4057qib7 11032 44 PFS PFS NNP cord-005453-4057qib7 11032 45 ) ) -RRB- cord-005453-4057qib7 11032 46 for for IN cord-005453-4057qib7 11032 47 allo allo NN cord-005453-4057qib7 11032 48 - - HYPH cord-005453-4057qib7 11032 49 SCT SCT NNP cord-005453-4057qib7 11032 50 . . . cord-005453-4057qib7 11033 1 With with IN cord-005453-4057qib7 11033 2 a a DT cord-005453-4057qib7 11033 3 median median NN cord-005453-4057qib7 11033 4 follow follow NN cord-005453-4057qib7 11033 5 up up IN cord-005453-4057qib7 11033 6 of of IN cord-005453-4057qib7 11033 7 57 57 CD cord-005453-4057qib7 11033 8 months month NNS cord-005453-4057qib7 11033 9 for for IN cord-005453-4057qib7 11033 10 patients patient NNS cord-005453-4057qib7 11033 11 receiving receive VBG cord-005453-4057qib7 11033 12 an an DT cord-005453-4057qib7 11033 13 ASCT ASCT NNP cord-005453-4057qib7 11033 14 , , , cord-005453-4057qib7 11033 15 21 21 CD cord-005453-4057qib7 11033 16 ( ( -LRB- cord-005453-4057qib7 11033 17 58 58 CD cord-005453-4057qib7 11033 18 % % NN cord-005453-4057qib7 11033 19 ) ) -RRB- cord-005453-4057qib7 11033 20 remain remain VBP cord-005453-4057qib7 11033 21 in in IN cord-005453-4057qib7 11033 22 CR CR NNP cord-005453-4057qib7 11033 23 . . . cord-005453-4057qib7 11034 1 In in IN cord-005453-4057qib7 11034 2 the the DT cord-005453-4057qib7 11034 3 allo allo NNP cord-005453-4057qib7 11034 4 - - HYPH cord-005453-4057qib7 11034 5 SCT SCT NNP cord-005453-4057qib7 11034 6 group group NN cord-005453-4057qib7 11034 7 median median NN cord-005453-4057qib7 11034 8 follow follow VBP cord-005453-4057qib7 11034 9 up up RP cord-005453-4057qib7 11034 10 is be VBZ cord-005453-4057qib7 11034 11 24 24 CD cord-005453-4057qib7 11034 12 months month NNS cord-005453-4057qib7 11034 13 for for IN cord-005453-4057qib7 11034 14 the the DT cord-005453-4057qib7 11034 15 whole whole JJ cord-005453-4057qib7 11034 16 group group NN cord-005453-4057qib7 11034 17 and and CC cord-005453-4057qib7 11034 18 50 50 CD cord-005453-4057qib7 11034 19 months month NNS cord-005453-4057qib7 11034 20 for for IN cord-005453-4057qib7 11034 21 alive alive JJ cord-005453-4057qib7 11034 22 patients patient NNS cord-005453-4057qib7 11034 23 ; ; : cord-005453-4057qib7 11034 24 9 9 CD cord-005453-4057qib7 11034 25 patients patient NNS cord-005453-4057qib7 11034 26 are be VBP cord-005453-4057qib7 11034 27 alive alive JJ cord-005453-4057qib7 11034 28 and and CC cord-005453-4057qib7 11034 29 disease disease NN cord-005453-4057qib7 11034 30 free free JJ cord-005453-4057qib7 11034 31 and and CC cord-005453-4057qib7 11034 32 6 6 CD cord-005453-4057qib7 11034 33 have have VBP cord-005453-4057qib7 11034 34 died die VBN cord-005453-4057qib7 11034 35 , , , cord-005453-4057qib7 11034 36 4 4 CD cord-005453-4057qib7 11034 37 due due IN cord-005453-4057qib7 11034 38 to to IN cord-005453-4057qib7 11034 39 TRM TRM NNP cord-005453-4057qib7 11034 40 ( ( -LRB- cord-005453-4057qib7 11034 41 28 28 CD cord-005453-4057qib7 11034 42 % % NN cord-005453-4057qib7 11034 43 ) ) -RRB- cord-005453-4057qib7 11034 44 . . . cord-005453-4057qib7 11035 1 Regarding regard VBG cord-005453-4057qib7 11035 2 progression progression NN cord-005453-4057qib7 11035 3 , , , cord-005453-4057qib7 11035 4 12 12 CD cord-005453-4057qib7 11035 5 ( ( -LRB- cord-005453-4057qib7 11035 6 33 33 CD cord-005453-4057qib7 11035 7 % % NN cord-005453-4057qib7 11035 8 ) ) -RRB- cord-005453-4057qib7 11035 9 have have VBP cord-005453-4057qib7 11035 10 progressed progress VBN cord-005453-4057qib7 11035 11 after after IN cord-005453-4057qib7 11035 12 autologous autologous JJ cord-005453-4057qib7 11035 13 transplant transplant NN cord-005453-4057qib7 11035 14 and and CC cord-005453-4057qib7 11035 15 2 2 CD cord-005453-4057qib7 11035 16 after after IN cord-005453-4057qib7 11035 17 allo allo NN cord-005453-4057qib7 11035 18 - - HYPH cord-005453-4057qib7 11035 19 SCT SCT NNP cord-005453-4057qib7 11035 20 . . . cord-005453-4057qib7 11036 1 Conclusions conclusion NNS cord-005453-4057qib7 11036 2 : : : cord-005453-4057qib7 11037 1 Indication indication NN cord-005453-4057qib7 11037 2 for for IN cord-005453-4057qib7 11037 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 11037 4 SCT SCT NNP cord-005453-4057qib7 11037 5 in in IN cord-005453-4057qib7 11037 6 transformed transform VBN cord-005453-4057qib7 11037 7 DLBCL DLBCL NNP cord-005453-4057qib7 11037 8 is be VBZ cord-005453-4057qib7 11037 9 stablished stablishe VBN cord-005453-4057qib7 11037 10 in in IN cord-005453-4057qib7 11037 11 few few JJ cord-005453-4057qib7 11037 12 patients patient NNS cord-005453-4057qib7 11037 13 . . . cord-005453-4057qib7 11038 1 Only only RB cord-005453-4057qib7 11038 2 2 2 CD cord-005453-4057qib7 11038 3 % % NN cord-005453-4057qib7 11038 4 of of IN cord-005453-4057qib7 11038 5 the the DT cord-005453-4057qib7 11038 6 patients patient NNS cord-005453-4057qib7 11038 7 in in IN cord-005453-4057qib7 11038 8 our -PRON- PRP$ cord-005453-4057qib7 11038 9 transplant transplant NN cord-005453-4057qib7 11038 10 Unit Unit NNP cord-005453-4057qib7 11038 11 receive receive VB cord-005453-4057qib7 11038 12 a a DT cord-005453-4057qib7 11038 13 transplant transplant NN cord-005453-4057qib7 11038 14 due due IN cord-005453-4057qib7 11038 15 to to IN cord-005453-4057qib7 11038 16 transformed transform VBN cord-005453-4057qib7 11038 17 lymphoma lymphoma NN cord-005453-4057qib7 11038 18 , , , cord-005453-4057qib7 11038 19 corresponding correspond VBG cord-005453-4057qib7 11038 20 to to IN cord-005453-4057qib7 11038 21 a a DT cord-005453-4057qib7 11038 22 2.3 2.3 CD cord-005453-4057qib7 11038 23 % % NN cord-005453-4057qib7 11038 24 of of IN cord-005453-4057qib7 11038 25 autologous autologous JJ cord-005453-4057qib7 11038 26 activity activity NN cord-005453-4057qib7 11038 27 and and CC cord-005453-4057qib7 11038 28 1.5 1.5 CD cord-005453-4057qib7 11038 29 % % NN cord-005453-4057qib7 11038 30 of of IN cord-005453-4057qib7 11038 31 allogeneic allogeneic NN cord-005453-4057qib7 11038 32 activity activity NN cord-005453-4057qib7 11038 33 . . . cord-005453-4057qib7 11039 1 According accord VBG cord-005453-4057qib7 11039 2 to to IN cord-005453-4057qib7 11039 3 our -PRON- PRP$ cord-005453-4057qib7 11039 4 results result NNS cord-005453-4057qib7 11039 5 transplant transplant NN cord-005453-4057qib7 11039 6 should should MD cord-005453-4057qib7 11039 7 be be VB cord-005453-4057qib7 11039 8 considered consider VBN cord-005453-4057qib7 11039 9 a a DT cord-005453-4057qib7 11039 10 curative curative JJ cord-005453-4057qib7 11039 11 option option NN cord-005453-4057qib7 11039 12 . . . cord-005453-4057qib7 11040 1 Most Most JJS cord-005453-4057qib7 11040 2 of of IN cord-005453-4057qib7 11040 3 our -PRON- PRP$ cord-005453-4057qib7 11040 4 patients patient NNS cord-005453-4057qib7 11040 5 were be VBD cord-005453-4057qib7 11040 6 transplanted transplant VBN cord-005453-4057qib7 11040 7 in in IN cord-005453-4057qib7 11040 8 CR CR NNP cord-005453-4057qib7 11040 9 , , , cord-005453-4057qib7 11040 10 so so RB cord-005453-4057qib7 11040 11 new new JJ cord-005453-4057qib7 11040 12 agents agent NNS cord-005453-4057qib7 11040 13 trying try VBG cord-005453-4057qib7 11040 14 to to TO cord-005453-4057qib7 11040 15 reach reach VB cord-005453-4057qib7 11040 16 best good JJS cord-005453-4057qib7 11040 17 response response NN cord-005453-4057qib7 11040 18 before before IN cord-005453-4057qib7 11040 19 transplant transplant NN cord-005453-4057qib7 11040 20 should should MD cord-005453-4057qib7 11040 21 be be VB cord-005453-4057qib7 11040 22 considered consider VBN cord-005453-4057qib7 11040 23 . . . cord-005453-4057qib7 11041 1 [ [ -LRB- cord-005453-4057qib7 11041 2 [ [ -LRB- cord-005453-4057qib7 11041 3 P488 P488 NNP cord-005453-4057qib7 11041 4 Image image NN cord-005453-4057qib7 11041 5 ] ] -RRB- cord-005453-4057qib7 11041 6 1 1 CD cord-005453-4057qib7 11041 7 . . . cord-005453-4057qib7 11041 8 _SP cord-005453-4057qib7 11042 1 Eva Eva NNP cord-005453-4057qib7 11042 2 Konirova Konirova NNP cord-005453-4057qib7 11042 3 1 1 CD cord-005453-4057qib7 11042 4 , , , cord-005453-4057qib7 11042 5 Antonin Antonin NNP cord-005453-4057qib7 11042 6 Vitek Vitek NNP cord-005453-4057qib7 11042 7 2 2 CD cord-005453-4057qib7 11042 8 , , , cord-005453-4057qib7 11042 9 Marta Marta NNP cord-005453-4057qib7 11042 10 Krejci Krejci NNP cord-005453-4057qib7 11042 11 3 3 CD cord-005453-4057qib7 11042 12 , , , cord-005453-4057qib7 11042 13 Edgar Edgar NNP cord-005453-4057qib7 11042 14 Faber Faber NNP cord-005453-4057qib7 11042 15 4 4 CD cord-005453-4057qib7 11042 16 , , , cord-005453-4057qib7 11042 17 Katerina Katerina NNP cord-005453-4057qib7 11042 18 Steinerova Steinerova NNP cord-005453-4057qib7 11042 19 5 5 CD cord-005453-4057qib7 11042 20 , , , cord-005453-4057qib7 11042 21 David David NNP cord-005453-4057qib7 11042 22 Belada Belada NNP cord-005453-4057qib7 11042 23 6 6 CD cord-005453-4057qib7 11042 24 , , , cord-005453-4057qib7 11042 25 Jan Jan NNP cord-005453-4057qib7 11042 26 Novak Novak NNP cord-005453-4057qib7 11042 27 7 7 CD cord-005453-4057qib7 11042 28 , , , cord-005453-4057qib7 11042 29 Juraj Juraj NNP cord-005453-4057qib7 11042 30 Duras Duras NNP cord-005453-4057qib7 11042 31 8 8 CD cord-005453-4057qib7 11042 32 , , , cord-005453-4057qib7 11042 33 Petr Petr NNP cord-005453-4057qib7 11042 34 Sedlacek Sedlacek NNP cord-005453-4057qib7 11042 35 9 9 CD cord-005453-4057qib7 11042 36 , , , cord-005453-4057qib7 11042 37 Veronika Veronika NNP cord-005453-4057qib7 11042 38 Valkova Valkova NNP cord-005453-4057qib7 11042 39 2 2 CD cord-005453-4057qib7 11042 40 , , , cord-005453-4057qib7 11042 41 Andrea Andrea NNP cord-005453-4057qib7 11042 42 Janikova Janikova NNP cord-005453-4057qib7 11042 43 3 3 CD cord-005453-4057qib7 11042 44 , , , cord-005453-4057qib7 11042 45 Ludek Ludek NNP cord-005453-4057qib7 11042 46 Raida Raida NNP cord-005453-4057qib7 11042 47 4 4 CD cord-005453-4057qib7 11042 48 , , , cord-005453-4057qib7 11042 49 Pavel Pavel NNP cord-005453-4057qib7 11042 50 Jindra Jindra NNP cord-005453-4057qib7 11042 51 5 5 CD cord-005453-4057qib7 11042 52 , , , cord-005453-4057qib7 11042 53 Pavel Pavel NNP cord-005453-4057qib7 11042 54 Zak Zak NNP cord-005453-4057qib7 11042 55 6 6 CD cord-005453-4057qib7 11042 56 , , , cord-005453-4057qib7 11042 57 Tomas Tomas NNP cord-005453-4057qib7 11042 58 Kozak Kozak NNP cord-005453-4057qib7 11042 59 10 10 CD cord-005453-4057qib7 11042 60 , , , cord-005453-4057qib7 11042 61 Marie Marie NNP cord-005453-4057qib7 11042 62 Trnkova Trnkova NNP cord-005453-4057qib7 11042 63 1 1 CD cord-005453-4057qib7 11042 64 , , , cord-005453-4057qib7 11042 65 Michal Michal NNP cord-005453-4057qib7 11042 66 Karas Karas NNP cord-005453-4057qib7 11042 67 5 5 CD cord-005453-4057qib7 11042 68 , , , cord-005453-4057qib7 11042 69 Marek Marek NNP cord-005453-4057qib7 11042 70 Trneny Trneny NNP cord-005453-4057qib7 11042 71 1 1 CD cord-005453-4057qib7 11042 72 management management NN cord-005453-4057qib7 11042 73 . . . cord-005453-4057qib7 11043 1 However however RB cord-005453-4057qib7 11043 2 , , , cord-005453-4057qib7 11043 3 differences difference NNS cord-005453-4057qib7 11043 4 in in IN cord-005453-4057qib7 11043 5 patient patient NN cord-005453-4057qib7 11043 6 's 's POS cord-005453-4057qib7 11043 7 characteristics characteristic NNS cord-005453-4057qib7 11043 8 as as RB cord-005453-4057qib7 11043 9 well well RB cord-005453-4057qib7 11043 10 as as IN cord-005453-4057qib7 11043 11 frequency frequency NN cord-005453-4057qib7 11043 12 of of IN cord-005453-4057qib7 11043 13 HSCT HSCT NNP cord-005453-4057qib7 11043 14 indication indication NN cord-005453-4057qib7 11043 15 in in IN cord-005453-4057qib7 11043 16 different different JJ cord-005453-4057qib7 11043 17 lymphoma lymphoma NN cord-005453-4057qib7 11043 18 subtypes subtype NNS cord-005453-4057qib7 11043 19 have have VBP cord-005453-4057qib7 11043 20 been be VBN cord-005453-4057qib7 11043 21 observed observe VBN cord-005453-4057qib7 11043 22 in in IN cord-005453-4057qib7 11043 23 the the DT cord-005453-4057qib7 11043 24 last last JJ cord-005453-4057qib7 11043 25 decade decade NN cord-005453-4057qib7 11043 26 . . . cord-005453-4057qib7 11044 1 The the DT cord-005453-4057qib7 11044 2 aim aim NN cord-005453-4057qib7 11044 3 of of IN cord-005453-4057qib7 11044 4 this this DT cord-005453-4057qib7 11044 5 study study NN cord-005453-4057qib7 11044 6 was be VBD cord-005453-4057qib7 11044 7 retrospective retrospective JJ cord-005453-4057qib7 11044 8 analysis analysis NN cord-005453-4057qib7 11044 9 of of IN cord-005453-4057qib7 11044 10 HSCT HSCT NNP cord-005453-4057qib7 11044 11 for for IN cord-005453-4057qib7 11044 12 lymphomas lymphoma NNS cord-005453-4057qib7 11044 13 in in IN cord-005453-4057qib7 11044 14 Czech Czech NNP cord-005453-4057qib7 11044 15 Republic Republic NNP cord-005453-4057qib7 11044 16 . . . cord-005453-4057qib7 11045 1 Methods method NNS cord-005453-4057qib7 11045 2 : : : cord-005453-4057qib7 11046 1 Data datum NNS cord-005453-4057qib7 11046 2 of of IN cord-005453-4057qib7 11046 3 adult adult NN cord-005453-4057qib7 11046 4 patients patient NNS cord-005453-4057qib7 11046 5 transplanted transplant VBN cord-005453-4057qib7 11046 6 between between IN cord-005453-4057qib7 11046 7 years year NNS cord-005453-4057qib7 11046 8 1993 1993 CD cord-005453-4057qib7 11046 9 - - SYM cord-005453-4057qib7 11046 10 2016 2016 CD cord-005453-4057qib7 11046 11 were be VBD cord-005453-4057qib7 11046 12 retrospectively retrospectively RB cord-005453-4057qib7 11046 13 analyzed analyze VBN cord-005453-4057qib7 11046 14 using use VBG cord-005453-4057qib7 11046 15 EBMT EBMT NNP cord-005453-4057qib7 11046 16 database database NN cord-005453-4057qib7 11046 17 . . . cord-005453-4057qib7 11047 1 Results result NNS cord-005453-4057qib7 11047 2 : : : cord-005453-4057qib7 11048 1 Between between IN cord-005453-4057qib7 11048 2 1993 1993 CD cord-005453-4057qib7 11048 3 and and CC cord-005453-4057qib7 11048 4 2016 2016 CD cord-005453-4057qib7 11048 5 , , , cord-005453-4057qib7 11048 6 2816 2816 CD cord-005453-4057qib7 11048 7 autologous autologous JJ cord-005453-4057qib7 11048 8 HSCT HSCT NNP cord-005453-4057qib7 11048 9 ( ( -LRB- cord-005453-4057qib7 11048 10 ASCT ASCT NNP cord-005453-4057qib7 11048 11 ) ) -RRB- cord-005453-4057qib7 11048 12 were be VBD cord-005453-4057qib7 11048 13 performed perform VBN cord-005453-4057qib7 11048 14 in in IN cord-005453-4057qib7 11048 15 2651 2651 CD cord-005453-4057qib7 11048 16 patients patient NNS cord-005453-4057qib7 11048 17 ( ( -LRB- cord-005453-4057qib7 11048 18 1511 1511 CD cord-005453-4057qib7 11048 19 men man NNS cord-005453-4057qib7 11048 20 , , , cord-005453-4057qib7 11048 21 57 57 CD cord-005453-4057qib7 11048 22 % % NN cord-005453-4057qib7 11048 23 ) ) -RRB- cord-005453-4057qib7 11048 24 with with IN cord-005453-4057qib7 11048 25 different different JJ cord-005453-4057qib7 11048 26 lymphoma lymphoma NN cord-005453-4057qib7 11048 27 subtypes subtype NNS cord-005453-4057qib7 11048 28 . . . cord-005453-4057qib7 11049 1 The the DT cord-005453-4057qib7 11049 2 median median JJ cord-005453-4057qib7 11049 3 age age NN cord-005453-4057qib7 11049 4 was be VBD cord-005453-4057qib7 11049 5 49 49 CD cord-005453-4057qib7 11049 6 years year NNS cord-005453-4057qib7 11050 1 ( ( -LRB- cord-005453-4057qib7 11050 2 range range NNP cord-005453-4057qib7 11050 3 18 18 CD cord-005453-4057qib7 11050 4 - - SYM cord-005453-4057qib7 11050 5 75 75 CD cord-005453-4057qib7 11050 6 ) ) -RRB- cord-005453-4057qib7 11050 7 . . . cord-005453-4057qib7 11051 1 Out out IN cord-005453-4057qib7 11051 2 of of IN cord-005453-4057qib7 11051 3 these these DT cord-005453-4057qib7 11051 4 , , , cord-005453-4057qib7 11051 5 2078 2078 CD cord-005453-4057qib7 11051 6 ( ( -LRB- cord-005453-4057qib7 11051 7 78 78 CD cord-005453-4057qib7 11051 8 % % NN cord-005453-4057qib7 11051 9 ) ) -RRB- cord-005453-4057qib7 11051 10 were be VBD cord-005453-4057qib7 11051 11 patients patient NNS cord-005453-4057qib7 11051 12 with with IN cord-005453-4057qib7 11051 13 non non JJ cord-005453-4057qib7 11051 14 - - JJ cord-005453-4057qib7 11051 15 Hodgkin hodgkin JJ cord-005453-4057qib7 11051 16 lymphoma lymphoma NN cord-005453-4057qib7 11051 17 ( ( -LRB- cord-005453-4057qib7 11051 18 NHL NHL NNP cord-005453-4057qib7 11051 19 ) ) -RRB- cord-005453-4057qib7 11051 20 , , , cord-005453-4057qib7 11051 21 569 569 CD cord-005453-4057qib7 11051 22 ( ( -LRB- cord-005453-4057qib7 11051 23 21 21 CD cord-005453-4057qib7 11051 24 % % NN cord-005453-4057qib7 11051 25 ) ) -RRB- cord-005453-4057qib7 11051 26 with with IN cord-005453-4057qib7 11051 27 Hodgkin Hodgkin NNP cord-005453-4057qib7 11051 28 lymphoma lymphoma NN cord-005453-4057qib7 11051 29 ( ( -LRB- cord-005453-4057qib7 11051 30 HL HL NNP cord-005453-4057qib7 11051 31 ) ) -RRB- cord-005453-4057qib7 11051 32 . . . cord-005453-4057qib7 11052 1 The the DT cord-005453-4057qib7 11052 2 NHL NHL NNP cord-005453-4057qib7 11052 3 group group NN cord-005453-4057qib7 11052 4 comprised comprise VBN cord-005453-4057qib7 11052 5 of of IN cord-005453-4057qib7 11052 6 diffuse diffuse JJ cord-005453-4057qib7 11052 7 large large JJ cord-005453-4057qib7 11052 8 B b NN cord-005453-4057qib7 11052 9 - - HYPH cord-005453-4057qib7 11052 10 cell cell NN cord-005453-4057qib7 11052 11 lymphoma lymphoma NN cord-005453-4057qib7 11052 12 ( ( -LRB- cord-005453-4057qib7 11052 13 DLBCL dlbcl RB cord-005453-4057qib7 11052 14 , , , cord-005453-4057qib7 11052 15 36 36 CD cord-005453-4057qib7 11052 16 % % NN cord-005453-4057qib7 11052 17 ) ) -RRB- cord-005453-4057qib7 11052 18 , , , cord-005453-4057qib7 11052 19 follicular follicular JJ cord-005453-4057qib7 11052 20 lymphoma lymphoma NN cord-005453-4057qib7 11052 21 ( ( -LRB- cord-005453-4057qib7 11052 22 FL FL NNP cord-005453-4057qib7 11052 23 , , , cord-005453-4057qib7 11052 24 18 18 CD cord-005453-4057qib7 11052 25 % % NN cord-005453-4057qib7 11052 26 ) ) -RRB- cord-005453-4057qib7 11052 27 , , , cord-005453-4057qib7 11052 28 mantle mantle NN cord-005453-4057qib7 11052 29 cell cell NN cord-005453-4057qib7 11052 30 lymphoma lymphoma NN cord-005453-4057qib7 11052 31 ( ( -LRB- cord-005453-4057qib7 11052 32 MCL MCL NNP cord-005453-4057qib7 11052 33 , , , cord-005453-4057qib7 11052 34 16 16 CD cord-005453-4057qib7 11052 35 % % NN cord-005453-4057qib7 11052 36 ) ) -RRB- cord-005453-4057qib7 11052 37 and and CC cord-005453-4057qib7 11052 38 T T NNP cord-005453-4057qib7 11052 39 - - HYPH cord-005453-4057qib7 11052 40 NHL NHL NNP cord-005453-4057qib7 11052 41 ( ( -LRB- cord-005453-4057qib7 11052 42 9 9 CD cord-005453-4057qib7 11052 43 % % NN cord-005453-4057qib7 11052 44 ) ) -RRB- cord-005453-4057qib7 11052 45 . . . cord-005453-4057qib7 11053 1 The the DT cord-005453-4057qib7 11053 2 frequency frequency NN cord-005453-4057qib7 11053 3 of of IN cord-005453-4057qib7 11053 4 ASCT ASCT NNP cord-005453-4057qib7 11053 5 in in IN cord-005453-4057qib7 11053 6 lymphomas lymphoma NNS cord-005453-4057qib7 11053 7 increased increase VBD cord-005453-4057qib7 11053 8 from from IN cord-005453-4057qib7 11053 9 1993 1993 CD cord-005453-4057qib7 11053 10 to to IN cord-005453-4057qib7 11053 11 2000 2000 CD cord-005453-4057qib7 11053 12 and and CC cord-005453-4057qib7 11053 13 has have VBZ cord-005453-4057qib7 11053 14 been be VBN cord-005453-4057qib7 11053 15 constant constant JJ cord-005453-4057qib7 11053 16 since since IN cord-005453-4057qib7 11053 17 2000 2000 CD cord-005453-4057qib7 11053 18 ( ( -LRB- cord-005453-4057qib7 11053 19 120 120 CD cord-005453-4057qib7 11053 20 - - SYM cord-005453-4057qib7 11053 21 130 130 CD cord-005453-4057qib7 11053 22 transplants transplant NNS cord-005453-4057qib7 11053 23 per per IN cord-005453-4057qib7 11053 24 year year NN cord-005453-4057qib7 11053 25 ) ) -RRB- cord-005453-4057qib7 11053 26 . . . cord-005453-4057qib7 11054 1 Differences difference NNS cord-005453-4057qib7 11054 2 in in IN cord-005453-4057qib7 11054 3 frequency frequency NN cord-005453-4057qib7 11054 4 of of IN cord-005453-4057qib7 11054 5 ASCT ASCT NNP cord-005453-4057qib7 11054 6 were be VBD cord-005453-4057qib7 11054 7 observed observe VBN cord-005453-4057qib7 11054 8 among among IN cord-005453-4057qib7 11054 9 lymphoma lymphoma NN cord-005453-4057qib7 11054 10 subtypes subtype NNS cord-005453-4057qib7 11055 1 -decreasing -decrease VBG cord-005453-4057qib7 11055 2 numbers number NNS cord-005453-4057qib7 11055 3 of of IN cord-005453-4057qib7 11055 4 DLBCL DLBCL NNP cord-005453-4057qib7 11055 5 and and CC cord-005453-4057qib7 11055 6 FL FL NNP cord-005453-4057qib7 11055 7 and and CC cord-005453-4057qib7 11055 8 increasing increase VBG cord-005453-4057qib7 11055 9 numbers number NNS cord-005453-4057qib7 11055 10 of of IN cord-005453-4057qib7 11055 11 T T NNP cord-005453-4057qib7 11055 12 - - HYPH cord-005453-4057qib7 11055 13 NHL NHL NNP cord-005453-4057qib7 11055 14 and and CC cord-005453-4057qib7 11055 15 MCL MCL NNP cord-005453-4057qib7 11055 16 , , , cord-005453-4057qib7 11055 17 with with IN cord-005453-4057qib7 11055 18 ASCT ASCT NNP cord-005453-4057qib7 11055 19 as as IN cord-005453-4057qib7 11055 20 part part NN cord-005453-4057qib7 11055 21 of of IN cord-005453-4057qib7 11055 22 the the DT cord-005453-4057qib7 11055 23 induction induction NN cord-005453-4057qib7 11055 24 therapy therapy NN cord-005453-4057qib7 11055 25 . . . cord-005453-4057qib7 11056 1 Between between IN cord-005453-4057qib7 11056 2 1996 1996 CD cord-005453-4057qib7 11056 3 and and CC cord-005453-4057qib7 11056 4 2016 2016 CD cord-005453-4057qib7 11056 5 a a DT cord-005453-4057qib7 11056 6 total total NN cord-005453-4057qib7 11056 7 of of IN cord-005453-4057qib7 11056 8 329 329 CD cord-005453-4057qib7 11056 9 allogeneic allogeneic NN cord-005453-4057qib7 11056 10 HSCT HSCT NNP cord-005453-4057qib7 11056 11 ( ( -LRB- cord-005453-4057qib7 11056 12 alloSCT alloSCT NNP cord-005453-4057qib7 11056 13 ) ) -RRB- cord-005453-4057qib7 11056 14 were be VBD cord-005453-4057qib7 11056 15 performed perform VBN cord-005453-4057qib7 11056 16 in in IN cord-005453-4057qib7 11056 17 319 319 CD cord-005453-4057qib7 11056 18 patients patient NNS cord-005453-4057qib7 11056 19 ( ( -LRB- cord-005453-4057qib7 11056 20 200 200 CD cord-005453-4057qib7 11056 21 men man NNS cord-005453-4057qib7 11056 22 , , , cord-005453-4057qib7 11056 23 63 63 CD cord-005453-4057qib7 11056 24 % % NN cord-005453-4057qib7 11056 25 ) ) -RRB- cord-005453-4057qib7 11056 26 . . . cord-005453-4057qib7 11057 1 Median median JJ cord-005453-4057qib7 11057 2 age age NN cord-005453-4057qib7 11057 3 was be VBD cord-005453-4057qib7 11057 4 46 46 CD cord-005453-4057qib7 11057 5 years year NNS cord-005453-4057qib7 11058 1 ( ( -LRB- cord-005453-4057qib7 11058 2 range range NNP cord-005453-4057qib7 11058 3 19 19 CD cord-005453-4057qib7 11058 4 - - SYM cord-005453-4057qib7 11058 5 66 66 CD cord-005453-4057qib7 11058 6 ) ) -RRB- cord-005453-4057qib7 11058 7 . . . cord-005453-4057qib7 11059 1 Out out IN cord-005453-4057qib7 11059 2 of of IN cord-005453-4057qib7 11059 3 these these DT cord-005453-4057qib7 11059 4 257 257 CD cord-005453-4057qib7 11059 5 ( ( -LRB- cord-005453-4057qib7 11059 6 81 81 CD cord-005453-4057qib7 11059 7 % % NN cord-005453-4057qib7 11059 8 ) ) -RRB- cord-005453-4057qib7 11059 9 were be VBD cord-005453-4057qib7 11059 10 patients patient NNS cord-005453-4057qib7 11059 11 with with IN cord-005453-4057qib7 11059 12 NHL NHL NNP cord-005453-4057qib7 11059 13 , , , cord-005453-4057qib7 11059 14 61 61 CD cord-005453-4057qib7 11059 15 ( ( -LRB- cord-005453-4057qib7 11059 16 18 18 CD cord-005453-4057qib7 11059 17 % % NN cord-005453-4057qib7 11059 18 ) ) -RRB- cord-005453-4057qib7 11059 19 HL HL NNP cord-005453-4057qib7 11059 20 . . . cord-005453-4057qib7 11060 1 The the DT cord-005453-4057qib7 11060 2 most most RBS cord-005453-4057qib7 11060 3 common common JJ cord-005453-4057qib7 11060 4 NHL NHL NNP cord-005453-4057qib7 11060 5 subtypes subtype NNS cord-005453-4057qib7 11060 6 were be VBD cord-005453-4057qib7 11060 7 FL FL NNP cord-005453-4057qib7 11060 8 ( ( -LRB- cord-005453-4057qib7 11060 9 27 27 CD cord-005453-4057qib7 11060 10 % % NN cord-005453-4057qib7 11060 11 ) ) -RRB- cord-005453-4057qib7 11060 12 , , , cord-005453-4057qib7 11060 13 MCL MCL NNP cord-005453-4057qib7 11060 14 ( ( -LRB- cord-005453-4057qib7 11060 15 22 22 CD cord-005453-4057qib7 11060 16 % % NN cord-005453-4057qib7 11060 17 ) ) -RRB- cord-005453-4057qib7 11060 18 , , , cord-005453-4057qib7 11060 19 T T NNP cord-005453-4057qib7 11060 20 - - HYPH cord-005453-4057qib7 11060 21 NHL NHL NNP cord-005453-4057qib7 11060 22 ( ( -LRB- cord-005453-4057qib7 11060 23 22 22 CD cord-005453-4057qib7 11060 24 % % NN cord-005453-4057qib7 11060 25 ) ) -RRB- cord-005453-4057qib7 11060 26 and and CC cord-005453-4057qib7 11060 27 DLBCL DLBCL NNP cord-005453-4057qib7 11060 28 ( ( -LRB- cord-005453-4057qib7 11060 29 16 16 CD cord-005453-4057qib7 11060 30 % % NN cord-005453-4057qib7 11060 31 ) ) -RRB- cord-005453-4057qib7 11060 32 . . . cord-005453-4057qib7 11061 1 In in IN cord-005453-4057qib7 11061 2 the the DT cord-005453-4057qib7 11061 3 last last JJ cord-005453-4057qib7 11061 4 10 10 CD cord-005453-4057qib7 11061 5 years year NNS cord-005453-4057qib7 11061 6 the the DT cord-005453-4057qib7 11061 7 number number NN cord-005453-4057qib7 11061 8 of of IN cord-005453-4057qib7 11061 9 alloSCT alloSCT NNP cord-005453-4057qib7 11061 10 for for IN cord-005453-4057qib7 11061 11 lymphoma lymphoma NN cord-005453-4057qib7 11061 12 is be VBZ cord-005453-4057qib7 11061 13 fluctuating fluctuate VBG cord-005453-4057qib7 11061 14 around around IN cord-005453-4057qib7 11061 15 20 20 CD cord-005453-4057qib7 11061 16 per per IN cord-005453-4057qib7 11061 17 year year NN cord-005453-4057qib7 11061 18 . . . cord-005453-4057qib7 11062 1 The the DT cord-005453-4057qib7 11062 2 median median JJ cord-005453-4057qib7 11062 3 age age NN cord-005453-4057qib7 11062 4 at at IN cord-005453-4057qib7 11062 5 ASCT ASCT NNP cord-005453-4057qib7 11062 6 was be VBD cord-005453-4057qib7 11062 7 significantly significantly RB cord-005453-4057qib7 11062 8 higher high JJR cord-005453-4057qib7 11062 9 in in IN cord-005453-4057qib7 11062 10 the the DT cord-005453-4057qib7 11062 11 years year NNS cord-005453-4057qib7 11062 12 2010 2010 CD cord-005453-4057qib7 11062 13 - - SYM cord-005453-4057qib7 11062 14 2016 2016 CD cord-005453-4057qib7 11062 15 vs vs IN cord-005453-4057qib7 11062 16 1993 1993 CD cord-005453-4057qib7 11062 17 - - SYM cord-005453-4057qib7 11062 18 2000 2000 CD cord-005453-4057qib7 11062 19 [ [ -LRB- cord-005453-4057qib7 11062 20 54.5 54.5 CD cord-005453-4057qib7 11062 21 ( ( -LRB- cord-005453-4057qib7 11062 22 18.1 18.1 CD cord-005453-4057qib7 11062 23 - - HYPH cord-005453-4057qib7 11062 24 74.8 74.8 CD cord-005453-4057qib7 11062 25 ) ) -RRB- cord-005453-4057qib7 11062 26 vs. vs. FW cord-005453-4057qib7 11062 27 40.9 40.9 CD cord-005453-4057qib7 11062 28 ( ( -LRB- cord-005453-4057qib7 11062 29 18.6 18.6 CD cord-005453-4057qib7 11062 30 - - HYPH cord-005453-4057qib7 11062 31 72.5 72.5 NNP cord-005453-4057qib7 11062 32 ) ) -RRB- cord-005453-4057qib7 11062 33 , , , cord-005453-4057qib7 11062 34 p p NN cord-005453-4057qib7 11062 35 < < XX cord-005453-4057qib7 11062 36 0.0001 0.0001 CD cord-005453-4057qib7 11062 37 , , , cord-005453-4057qib7 11062 38 fig fig NN cord-005453-4057qib7 11062 39 1 1 CD cord-005453-4057qib7 11062 40 ] ] -RRB- cord-005453-4057qib7 11062 41 , , , cord-005453-4057qib7 11062 42 while while IN cord-005453-4057qib7 11062 43 the the DT cord-005453-4057qib7 11062 44 increase increase NN cord-005453-4057qib7 11062 45 at at IN cord-005453-4057qib7 11062 46 alloSCT alloSCT NNP cord-005453-4057qib7 11062 47 [ [ -LRB- cord-005453-4057qib7 11062 48 46.5 46.5 CD cord-005453-4057qib7 11062 49 ( ( -LRB- cord-005453-4057qib7 11062 50 21.3 21.3 CD cord-005453-4057qib7 11062 51 - - HYPH cord-005453-4057qib7 11062 52 65.5 65.5 CD cord-005453-4057qib7 11062 53 ) ) -RRB- cord-005453-4057qib7 11062 54 vs vs IN cord-005453-4057qib7 11062 55 41.6(20.3 41.6(20.3 NNP cord-005453-4057qib7 11062 56 - - HYPH cord-005453-4057qib7 11062 57 64.5 64.5 CD cord-005453-4057qib7 11062 58 ) ) -RRB- cord-005453-4057qib7 11062 59 ] ] -RRB- cord-005453-4057qib7 11062 60 did do VBD cord-005453-4057qib7 11062 61 not not RB cord-005453-4057qib7 11062 62 reach reach VB cord-005453-4057qib7 11062 63 statistical statistical JJ cord-005453-4057qib7 11062 64 significance significance NN cord-005453-4057qib7 11062 65 ( ( -LRB- cord-005453-4057qib7 11062 66 p=0.07 p=0.07 NNP cord-005453-4057qib7 11062 67 ) ) -RRB- cord-005453-4057qib7 11062 68 . . . cord-005453-4057qib7 11063 1 With with IN cord-005453-4057qib7 11063 2 median median NN cord-005453-4057qib7 11063 3 follow follow VB cord-005453-4057qib7 11063 4 up up RP cord-005453-4057qib7 11063 5 for for IN cord-005453-4057qib7 11063 6 alloSCT alloSCT NNP cord-005453-4057qib7 11063 7 , , , cord-005453-4057qib7 11063 8 5 5 CD cord-005453-4057qib7 11063 9 y y NN cord-005453-4057qib7 11063 10 probability probability NN cord-005453-4057qib7 11063 11 OS OS NNP cord-005453-4057qib7 11063 12 for for IN cord-005453-4057qib7 11063 13 patient patient NN cord-005453-4057qib7 11063 14 transplanted transplant VBN cord-005453-4057qib7 11063 15 in in IN cord-005453-4057qib7 11063 16 the the DT cord-005453-4057qib7 11063 17 later later JJ cord-005453-4057qib7 11063 18 period period NN cord-005453-4057qib7 11063 19 2010 2010 CD cord-005453-4057qib7 11063 20 - - SYM cord-005453-4057qib7 11063 21 2016 2016 CD cord-005453-4057qib7 11063 22 was be VBD cord-005453-4057qib7 11063 23 in in IN cord-005453-4057qib7 11063 24 relapsed relapse VBN cord-005453-4057qib7 11063 25 DLBCL DLBCL NNP cord-005453-4057qib7 11063 26 25.7 25.7 CD cord-005453-4057qib7 11063 27 % % NN cord-005453-4057qib7 11063 28 , , , cord-005453-4057qib7 11063 29 in in IN cord-005453-4057qib7 11063 30 FL FL NNP cord-005453-4057qib7 11063 31 77.4 77.4 CD cord-005453-4057qib7 11063 32 % % NN cord-005453-4057qib7 11063 33 , , , cord-005453-4057qib7 11063 34 in in IN cord-005453-4057qib7 11063 35 HL HL NNP cord-005453-4057qib7 11063 36 51.0 51.0 CD cord-005453-4057qib7 11063 37 % % NN cord-005453-4057qib7 11063 38 and and CC cord-005453-4057qib7 11063 39 in in IN cord-005453-4057qib7 11063 40 MCL MCL NNP cord-005453-4057qib7 11063 41 45.7 45.7 CD cord-005453-4057qib7 11063 42 % % NN cord-005453-4057qib7 11063 43 , , , cord-005453-4057qib7 11063 44 5 5 CD cord-005453-4057qib7 11063 45 y y NN cord-005453-4057qib7 11063 46 OS os NN cord-005453-4057qib7 11063 47 for for IN cord-005453-4057qib7 11063 48 ASCT ASCT NNP cord-005453-4057qib7 11063 49 as as IN cord-005453-4057qib7 11063 50 part part NN cord-005453-4057qib7 11063 51 of of IN cord-005453-4057qib7 11063 52 first first JJ cord-005453-4057qib7 11063 53 line line NN cord-005453-4057qib7 11063 54 therapy therapy NN cord-005453-4057qib7 11063 55 in in IN cord-005453-4057qib7 11063 56 the the DT cord-005453-4057qib7 11063 57 same same JJ cord-005453-4057qib7 11063 58 period period NN cord-005453-4057qib7 11064 1 was be VBD cord-005453-4057qib7 11064 2 in in IN cord-005453-4057qib7 11064 3 MCL MCL NNP cord-005453-4057qib7 11064 4 78.1 78.1 CD cord-005453-4057qib7 11064 5 % % NN cord-005453-4057qib7 11064 6 and and CC cord-005453-4057qib7 11064 7 in in IN cord-005453-4057qib7 11064 8 T T NNP cord-005453-4057qib7 11064 9 - - HYPH cord-005453-4057qib7 11064 10 NHL NHL NNP cord-005453-4057qib7 11064 11 48.2 48.2 CD cord-005453-4057qib7 11064 12 % % NN cord-005453-4057qib7 11064 13 . . . cord-005453-4057qib7 11065 1 OS OS NNP cord-005453-4057qib7 11065 2 was be VBD cord-005453-4057qib7 11065 3 significantly significantly RB cord-005453-4057qib7 11065 4 better well JJR cord-005453-4057qib7 11065 5 in in IN cord-005453-4057qib7 11065 6 all all DT cord-005453-4057qib7 11065 7 patients patient NNS cord-005453-4057qib7 11065 8 who who WP cord-005453-4057qib7 11065 9 underwent undergo VBD cord-005453-4057qib7 11065 10 ASCT ASCT NNP cord-005453-4057qib7 11065 11 in in IN cord-005453-4057qib7 11065 12 the the DT cord-005453-4057qib7 11065 13 years year NNS cord-005453-4057qib7 11065 14 2010 2010 CD cord-005453-4057qib7 11065 15 - - SYM cord-005453-4057qib7 11065 16 2016 2016 CD cord-005453-4057qib7 11065 17 vs vs IN cord-005453-4057qib7 11065 18 1993 1993 CD cord-005453-4057qib7 11065 19 - - SYM cord-005453-4057qib7 11065 20 2000 2000 CD cord-005453-4057qib7 11065 21 ( ( -LRB- cord-005453-4057qib7 11065 22 70.% 70.% CD cord-005453-4057qib7 11065 23 vs. vs. IN cord-005453-4057qib7 11065 24 57 57 CD cord-005453-4057qib7 11065 25 .5 .5 CD cord-005453-4057qib7 11065 26 % % NN cord-005453-4057qib7 11065 27 , , , cord-005453-4057qib7 11065 28 p p NN cord-005453-4057qib7 11065 29 < < XX cord-005453-4057qib7 11065 30 0.0001 0.0001 CD cord-005453-4057qib7 11065 31 ) ) -RRB- cord-005453-4057qib7 11065 32 and and CC cord-005453-4057qib7 11065 33 there there EX cord-005453-4057qib7 11065 34 was be VBD cord-005453-4057qib7 11065 35 a a DT cord-005453-4057qib7 11065 36 trend trend NN cord-005453-4057qib7 11065 37 towards towards IN cord-005453-4057qib7 11065 38 better well JJR cord-005453-4057qib7 11065 39 OS os NN cord-005453-4057qib7 11065 40 in in IN cord-005453-4057qib7 11065 41 patients patient NNS cord-005453-4057qib7 11065 42 after after IN cord-005453-4057qib7 11065 43 alloSCT alloSCT NNP cord-005453-4057qib7 11065 44 ( ( -LRB- cord-005453-4057qib7 11065 45 with with IN cord-005453-4057qib7 11065 46 44.7 44.7 CD cord-005453-4057qib7 11065 47 % % NN cord-005453-4057qib7 11065 48 vs vs IN cord-005453-4057qib7 11065 49 23.5 23.5 CD cord-005453-4057qib7 11065 50 % % NN cord-005453-4057qib7 11065 51 , , , cord-005453-4057qib7 11065 52 p=0.1084 p=0.1084 '' cord-005453-4057qib7 11065 53 ) ) -RRB- cord-005453-4057qib7 11066 1 ( ( -LRB- cord-005453-4057qib7 11066 2 fig fig NNP cord-005453-4057qib7 11066 3 2 2 CD cord-005453-4057qib7 11066 4 ) ) -RRB- cord-005453-4057qib7 11066 5 . . . cord-005453-4057qib7 11067 1 Conclusions conclusion NNS cord-005453-4057qib7 11067 2 : : : cord-005453-4057qib7 11068 1 HSCT HSCT NNP cord-005453-4057qib7 11068 2 remains remain VBZ cord-005453-4057qib7 11068 3 important important JJ cord-005453-4057qib7 11068 4 treatment treatment NN cord-005453-4057qib7 11068 5 modality modality NN cord-005453-4057qib7 11068 6 for for IN cord-005453-4057qib7 11068 7 lymphomas lymphoma NNS cord-005453-4057qib7 11068 8 in in IN cord-005453-4057qib7 11068 9 the the DT cord-005453-4057qib7 11068 10 era era NN cord-005453-4057qib7 11068 11 of of IN cord-005453-4057qib7 11068 12 targeted targeted JJ cord-005453-4057qib7 11068 13 antibody antibody NN cord-005453-4057qib7 11068 14 and and CC cord-005453-4057qib7 11068 15 molecular molecular JJ cord-005453-4057qib7 11068 16 therapy therapy NN cord-005453-4057qib7 11068 17 and and CC cord-005453-4057qib7 11068 18 we -PRON- PRP cord-005453-4057qib7 11068 19 can can MD cord-005453-4057qib7 11068 20 transplant transplant VB cord-005453-4057qib7 11068 21 older old JJR cord-005453-4057qib7 11068 22 patients patient NNS cord-005453-4057qib7 11068 23 due due JJ cord-005453-4057qib7 11068 24 to to IN cord-005453-4057qib7 11068 25 better well JJR cord-005453-4057qib7 11068 26 supportive supportive JJ cord-005453-4057qib7 11068 27 treatment treatment NN cord-005453-4057qib7 11068 28 . . . cord-005453-4057qib7 11069 1 Acknowledgment acknowledgment NN cord-005453-4057qib7 11069 2 : : : cord-005453-4057qib7 11069 3 PROGRESS PROGRESS NNP cord-005453-4057qib7 11069 4 Q28 Q28 NNP cord-005453-4057qib7 11069 5 - - HYPH cord-005453-4057qib7 11069 6 9 9 CD cord-005453-4057qib7 11069 7 UK UK NNP cord-005453-4057qib7 11069 8 from from IN cord-005453-4057qib7 11069 9 the the DT cord-005453-4057qib7 11069 10 Czech Czech NNP cord-005453-4057qib7 11069 11 Ministry Ministry NNP cord-005453-4057qib7 11069 12 of of IN cord-005453-4057qib7 11069 13 Education Education NNP cord-005453-4057qib7 11069 14 Youth Youth NNP cord-005453-4057qib7 11069 15 and and CC cord-005453-4057qib7 11069 16 Sports Sports NNPS cord-005453-4057qib7 11069 17 Disclosure Disclosure NNP cord-005453-4057qib7 11069 18 : : : cord-005453-4057qib7 11069 19 Nothing nothing NN cord-005453-4057qib7 11069 20 to to TO cord-005453-4057qib7 11069 21 declare declare VB cord-005453-4057qib7 11069 22 Background background NN cord-005453-4057qib7 11069 23 : : : cord-005453-4057qib7 11069 24 Disease Disease NNP cord-005453-4057qib7 11069 25 chemosensitivity chemosensitivity NN cord-005453-4057qib7 11069 26 to to TO cord-005453-4057qib7 11069 27 salvage salvage VB cord-005453-4057qib7 11069 28 treatment treatment NN cord-005453-4057qib7 11069 29 has have VBZ cord-005453-4057qib7 11069 30 been be VBN cord-005453-4057qib7 11069 31 proven prove VBN cord-005453-4057qib7 11069 32 to to TO cord-005453-4057qib7 11069 33 be be VB cord-005453-4057qib7 11069 34 a a DT cord-005453-4057qib7 11069 35 major major JJ cord-005453-4057qib7 11069 36 predictive predictive JJ cord-005453-4057qib7 11069 37 factor factor NN cord-005453-4057qib7 11069 38 for for IN cord-005453-4057qib7 11069 39 a a DT cord-005453-4057qib7 11069 40 favorable favorable JJ cord-005453-4057qib7 11069 41 outcome outcome NN cord-005453-4057qib7 11069 42 after after IN cord-005453-4057qib7 11069 43 autologous autologous JJ cord-005453-4057qib7 11069 44 stem stem NN cord-005453-4057qib7 11069 45 cell cell NN cord-005453-4057qib7 11069 46 transplantation transplantation NN cord-005453-4057qib7 11069 47 ( ( -LRB- cord-005453-4057qib7 11069 48 ASCT ASCT NNP cord-005453-4057qib7 11069 49 ) ) -RRB- cord-005453-4057qib7 11069 50 for for IN cord-005453-4057qib7 11069 51 patients patient NNS cord-005453-4057qib7 11069 52 with with IN cord-005453-4057qib7 11069 53 refractory refractory JJ cord-005453-4057qib7 11069 54 lymphomas lymphoma NNS cord-005453-4057qib7 11069 55 . . . cord-005453-4057qib7 11070 1 Therefore therefore RB cord-005453-4057qib7 11070 2 the the DT cord-005453-4057qib7 11070 3 importance importance NN cord-005453-4057qib7 11070 4 of of IN cord-005453-4057qib7 11070 5 effective effective JJ cord-005453-4057qib7 11070 6 and and CC cord-005453-4057qib7 11070 7 safe safe JJ cord-005453-4057qib7 11070 8 salvageregimens salvageregimen NNS cord-005453-4057qib7 11070 9 is be VBZ cord-005453-4057qib7 11070 10 indisputable indisputable JJ cord-005453-4057qib7 11070 11 . . . cord-005453-4057qib7 11071 1 Methods method NNS cord-005453-4057qib7 11071 2 : : : cord-005453-4057qib7 11072 1 We -PRON- PRP cord-005453-4057qib7 11072 2 retrospectively retrospectively RB cord-005453-4057qib7 11072 3 compared compare VBD cord-005453-4057qib7 11072 4 the the DT cord-005453-4057qib7 11072 5 outcomes outcome NNS cord-005453-4057qib7 11072 6 in in IN cord-005453-4057qib7 11072 7 terms term NNS cord-005453-4057qib7 11072 8 of of IN cord-005453-4057qib7 11072 9 safety safety NN cord-005453-4057qib7 11072 10 and and CC cord-005453-4057qib7 11072 11 efficacy efficacy NN cord-005453-4057qib7 11072 12 , , , cord-005453-4057qib7 11072 13 in in IN cord-005453-4057qib7 11072 14 67 67 CD cord-005453-4057qib7 11072 15 ( ( -LRB- cord-005453-4057qib7 11072 16 HL:36 HL:36 NNP cord-005453-4057qib7 11072 17 , , , cord-005453-4057qib7 11072 18 NHL:31 NHL:31 NNP cord-005453-4057qib7 11072 19 ) ) -RRB- cord-005453-4057qib7 11072 20 patients patient NNS cord-005453-4057qib7 11072 21 , , , cord-005453-4057qib7 11072 22 with with IN cord-005453-4057qib7 11072 23 a a DT cord-005453-4057qib7 11072 24 median median JJ cord-005453-4057qib7 11072 25 age age NN cord-005453-4057qib7 11072 26 of of IN cord-005453-4057qib7 11072 27 34.5(16 34.5(16 CD cord-005453-4057qib7 11072 28 - - SYM cord-005453-4057qib7 11072 29 75 75 CD cord-005453-4057qib7 11072 30 ) ) -RRB- cord-005453-4057qib7 11072 31 years year NNS cord-005453-4057qib7 11072 32 , , , cord-005453-4057qib7 11072 33 who who WP cord-005453-4057qib7 11072 34 received receive VBD cord-005453-4057qib7 11072 35 as as IN cord-005453-4057qib7 11072 36 1 1 CD cord-005453-4057qib7 11072 37 st st NNP cord-005453-4057qib7 11072 38 salvage salvage NN cord-005453-4057qib7 11072 39 either either CC cord-005453-4057qib7 11072 40 DICEP DICEP NNP cord-005453-4057qib7 11073 1 [ [ -LRB- cord-005453-4057qib7 11073 2 Cyclophoshamide Cyclophoshamide NNP cord-005453-4057qib7 11073 3 ( ( -LRB- cord-005453-4057qib7 11073 4 1750 1750 CD cord-005453-4057qib7 11073 5 mg mg NNP cord-005453-4057qib7 11073 6 / / SYM cord-005453-4057qib7 11073 7 m m NNP cord-005453-4057qib7 11073 8 2 2 CD cord-005453-4057qib7 11073 9 ) ) -RRB- cord-005453-4057qib7 11073 10 , , , cord-005453-4057qib7 11073 11 Etoposide Etoposide NNP cord-005453-4057qib7 11073 12 ( ( -LRB- cord-005453-4057qib7 11073 13 350mg 350mg NNP cord-005453-4057qib7 11073 14 / / SYM cord-005453-4057qib7 11073 15 m m NNP cord-005453-4057qib7 11073 16 2 2 CD cord-005453-4057qib7 11073 17 ) ) -RRB- cord-005453-4057qib7 11073 18 , , . cord-005453-4057qib7 11074 1 Cisplatin cisplatin NN cord-005453-4057qib7 11074 2 ( ( -LRB- cord-005453-4057qib7 11074 3 35 35 CD cord-005453-4057qib7 11074 4 mg/ mg/ NN cord-005453-4057qib7 11074 5 m m NNP cord-005453-4057qib7 11074 6 2 2 CD cord-005453-4057qib7 11074 7 ) ) -RRB- cord-005453-4057qib7 11074 8 , , , cord-005453-4057qib7 11074 9 days day NNS cord-005453-4057qib7 11074 10 1 1 CD cord-005453-4057qib7 11074 11 - - SYM cord-005453-4057qib7 11074 12 3 3 CD cord-005453-4057qib7 11074 13 , , , cord-005453-4057qib7 11074 14 ( ( -LRB- cord-005453-4057qib7 11074 15 n=23 n=23 NN cord-005453-4057qib7 11074 16 ) ) -RRB- cord-005453-4057qib7 11074 17 ] ] -RRB- cord-005453-4057qib7 11074 18 or or CC cord-005453-4057qib7 11074 19 the the DT cord-005453-4057qib7 11074 20 widely widely RB cord-005453-4057qib7 11074 21 used use VBN cord-005453-4057qib7 11074 22 regimen regimen NN cord-005453-4057qib7 11074 23 ESHAP ESHAP NNP cord-005453-4057qib7 11074 24 ( ( -LRB- cord-005453-4057qib7 11074 25 n=44 n=44 NNP cord-005453-4057qib7 11074 26 ) ) -RRB- cord-005453-4057qib7 11074 27 . . . cord-005453-4057qib7 11075 1 Rituximab Rituximab NNP cord-005453-4057qib7 11075 2 was be VBD cord-005453-4057qib7 11075 3 additionally additionally RB cord-005453-4057qib7 11075 4 given give VBN cord-005453-4057qib7 11075 5 to to IN cord-005453-4057qib7 11075 6 all all DT cord-005453-4057qib7 11075 7 CD-20 CD-20 NNP cord-005453-4057qib7 11075 8 positive positive JJ cord-005453-4057qib7 11075 9 lymphoma lymphoma NN cord-005453-4057qib7 11075 10 patients patient NNS cord-005453-4057qib7 11075 11 . . . cord-005453-4057qib7 11076 1 The the DT cord-005453-4057qib7 11076 2 statistical statistical JJ cord-005453-4057qib7 11076 3 analysis analysis NN cord-005453-4057qib7 11076 4 based base VBN cord-005453-4057qib7 11076 5 on on IN cord-005453-4057qib7 11076 6 the the DT cord-005453-4057qib7 11076 7 independent independent JJ cord-005453-4057qib7 11076 8 T t NN cord-005453-4057qib7 11076 9 - - HYPH cord-005453-4057qib7 11076 10 test test NN cord-005453-4057qib7 11076 11 , , , cord-005453-4057qib7 11076 12 Kaplan Kaplan NNP cord-005453-4057qib7 11076 13 Meir Meir NNP cord-005453-4057qib7 11076 14 method method NN cord-005453-4057qib7 11076 15 and and CC cord-005453-4057qib7 11076 16 logrank logrank NN cord-005453-4057qib7 11076 17 test test NN cord-005453-4057qib7 11076 18 . . . cord-005453-4057qib7 11077 1 Results result NNS cord-005453-4057qib7 11077 2 : : : cord-005453-4057qib7 11078 1 The the DT cord-005453-4057qib7 11078 2 reason reason NN cord-005453-4057qib7 11078 3 for for IN cord-005453-4057qib7 11078 4 salvage salvage NN cord-005453-4057qib7 11078 5 treatment treatment NN cord-005453-4057qib7 11078 6 was be VBD cord-005453-4057qib7 11078 7 primary primary JJ cord-005453-4057qib7 11078 8 induction induction NN cord-005453-4057qib7 11078 9 failure failure NN cord-005453-4057qib7 11078 10 ( ( -LRB- cord-005453-4057qib7 11078 11 PIF PIF NNP cord-005453-4057qib7 11078 12 , , , cord-005453-4057qib7 11078 13 n=34 n=34 NNP cord-005453-4057qib7 11078 14 ) ) -RRB- cord-005453-4057qib7 11078 15 , , , cord-005453-4057qib7 11078 16 early early JJ cord-005453-4057qib7 11078 17 relapse relapse NN cord-005453-4057qib7 11078 18 ( ( -LRB- cord-005453-4057qib7 11078 19 < < NNP cord-005453-4057qib7 11078 20 12 12 CD cord-005453-4057qib7 11078 21 months month NNS cord-005453-4057qib7 11078 22 post post NN cord-005453-4057qib7 11078 23 induction induction NN cord-005453-4057qib7 11078 24 - - HYPH cord-005453-4057qib7 11078 25 remission remission NN cord-005453-4057qib7 11078 26 therapy therapy NN cord-005453-4057qib7 11078 27 n=14 n=14 NNP cord-005453-4057qib7 11078 28 ) ) -RRB- cord-005453-4057qib7 11078 29 and and CC cord-005453-4057qib7 11078 30 late late JJ cord-005453-4057qib7 11078 31 relapsed relapsed JJ cord-005453-4057qib7 11078 32 disease disease NN cord-005453-4057qib7 11078 33 ( ( -LRB- cord-005453-4057qib7 11078 34 n=19 n=19 NN cord-005453-4057qib7 11078 35 ) ) -RRB- cord-005453-4057qib7 11078 36 . . . cord-005453-4057qib7 11079 1 More more RBR cord-005453-4057qib7 11079 2 specifically specifically RB cord-005453-4057qib7 11079 3 , , , cord-005453-4057qib7 11079 4 19/23 19/23 CD cord-005453-4057qib7 11079 5 patients patient NNS cord-005453-4057qib7 11079 6 ( ( -LRB- cord-005453-4057qib7 11079 7 83 83 CD cord-005453-4057qib7 11079 8 % % NN cord-005453-4057qib7 11079 9 ) ) -RRB- cord-005453-4057qib7 11079 10 in in IN cord-005453-4057qib7 11079 11 the the DT cord-005453-4057qib7 11079 12 DICEP DICEP NNP cord-005453-4057qib7 11079 13 - - HYPH cord-005453-4057qib7 11079 14 group group NN cord-005453-4057qib7 11079 15 , , , cord-005453-4057qib7 11079 16 and and CC cord-005453-4057qib7 11079 17 29/44 29/44 CD cord-005453-4057qib7 11079 18 patients patient NNS cord-005453-4057qib7 11079 19 ( ( -LRB- cord-005453-4057qib7 11079 20 65 65 CD cord-005453-4057qib7 11079 21 % % NN cord-005453-4057qib7 11079 22 ) ) -RRB- cord-005453-4057qib7 11079 23 in in IN cord-005453-4057qib7 11079 24 the the DT cord-005453-4057qib7 11079 25 ESHAPgroup eshapgroup NN cord-005453-4057qib7 11079 26 were be VBD cord-005453-4057qib7 11079 27 assessed assess VBN cord-005453-4057qib7 11079 28 with with IN cord-005453-4057qib7 11079 29 PIF PIF NNP cord-005453-4057qib7 11079 30 or or CC cord-005453-4057qib7 11079 31 early early JJ cord-005453-4057qib7 11079 32 relapsed relapse VBN cord-005453-4057qib7 11079 33 disease disease NN cord-005453-4057qib7 11079 34 , , , cord-005453-4057qib7 11079 35 however however RB cord-005453-4057qib7 11079 36 this this DT cord-005453-4057qib7 11079 37 difference difference NN cord-005453-4057qib7 11079 38 was be VBD cord-005453-4057qib7 11079 39 not not RB cord-005453-4057qib7 11079 40 statistically statistically RB cord-005453-4057qib7 11079 41 significant significant JJ cord-005453-4057qib7 11079 42 . . . cord-005453-4057qib7 11080 1 Both both DT cord-005453-4057qib7 11080 2 regimens regimen NNS cord-005453-4057qib7 11080 3 were be VBD cord-005453-4057qib7 11080 4 well well RB cord-005453-4057qib7 11080 5 tolerated tolerate VBN cord-005453-4057qib7 11080 6 and and CC cord-005453-4057qib7 11080 7 no no DT cord-005453-4057qib7 11080 8 major major JJ cord-005453-4057qib7 11080 9 organ organ NN cord-005453-4057qib7 11080 10 toxicities toxicity NNS cord-005453-4057qib7 11080 11 were be VBD cord-005453-4057qib7 11080 12 noticed notice VBN cord-005453-4057qib7 11080 13 . . . cord-005453-4057qib7 11081 1 Eleven eleven CD cord-005453-4057qib7 11081 2 patients patient NNS cord-005453-4057qib7 11081 3 ( ( -LRB- cord-005453-4057qib7 11081 4 48 48 CD cord-005453-4057qib7 11081 5 % % NN cord-005453-4057qib7 11081 6 ) ) -RRB- cord-005453-4057qib7 11081 7 from from IN cord-005453-4057qib7 11081 8 the the DT cord-005453-4057qib7 11081 9 DICEP DICEP NNP cord-005453-4057qib7 11081 10 - - HYPH cord-005453-4057qib7 11081 11 group group NN cord-005453-4057qib7 11081 12 , , , cord-005453-4057qib7 11081 13 while while IN cord-005453-4057qib7 11081 14 only only RB cord-005453-4057qib7 11081 15 4(10 4(10 CD cord-005453-4057qib7 11081 16 % % NN cord-005453-4057qib7 11081 17 ) ) -RRB- cord-005453-4057qib7 11081 18 from from IN cord-005453-4057qib7 11081 19 the the DT cord-005453-4057qib7 11081 20 ESHAP ESHAP NNP cord-005453-4057qib7 11081 21 - - HYPH cord-005453-4057qib7 11081 22 group group NN cord-005453-4057qib7 11081 23 developed develop VBD cord-005453-4057qib7 11081 24 febrile febrile JJ cord-005453-4057qib7 11081 25 infections infection NNS cord-005453-4057qib7 11081 26 . . . cord-005453-4057qib7 11082 1 All all DT cord-005453-4057qib7 11082 2 patients patient NNS cord-005453-4057qib7 11082 3 were be VBD cord-005453-4057qib7 11082 4 successfully successfully RB cord-005453-4057qib7 11082 5 managed manage VBN cord-005453-4057qib7 11082 6 with with IN cord-005453-4057qib7 11082 7 the the DT cord-005453-4057qib7 11082 8 appropriate appropriate JJ cord-005453-4057qib7 11082 9 treatment treatment NN cord-005453-4057qib7 11082 10 and and CC cord-005453-4057qib7 11082 11 only only RB cord-005453-4057qib7 11082 12 one one CD cord-005453-4057qib7 11082 13 , , , cord-005453-4057qib7 11082 14 from from IN cord-005453-4057qib7 11082 15 the the DT cord-005453-4057qib7 11082 16 ESHAP ESHAP NNP cord-005453-4057qib7 11082 17 - - HYPH cord-005453-4057qib7 11082 18 group group NN cord-005453-4057qib7 11082 19 , , , cord-005453-4057qib7 11082 20 required require VBN cord-005453-4057qib7 11082 21 for for IN cord-005453-4057qib7 11082 22 short short JJ cord-005453-4057qib7 11082 23 period period NN cord-005453-4057qib7 11082 24 admission admission NN cord-005453-4057qib7 11082 25 to to IN cord-005453-4057qib7 11082 26 the the DT cord-005453-4057qib7 11082 27 intensive intensive JJ cord-005453-4057qib7 11082 28 care care NN cord-005453-4057qib7 11082 29 unit unit NN cord-005453-4057qib7 11082 30 . . . cord-005453-4057qib7 11083 1 After after IN cord-005453-4057qib7 11083 2 1 1 CD cord-005453-4057qib7 11083 3 cycle cycle NN cord-005453-4057qib7 11083 4 of of IN cord-005453-4057qib7 11083 5 DICEP DICEP NNP cord-005453-4057qib7 11083 6 and and CC cord-005453-4057qib7 11083 7 2 2 CD cord-005453-4057qib7 11083 8 cycles cycle NNS cord-005453-4057qib7 11083 9 of of IN cord-005453-4057qib7 11083 10 ESHAP ESHAP NNP cord-005453-4057qib7 11084 1 the the DT cord-005453-4057qib7 11084 2 disease disease NN cord-005453-4057qib7 11084 3 response response NN cord-005453-4057qib7 11084 4 was be VBD cord-005453-4057qib7 11084 5 re re VBN cord-005453-4057qib7 11084 6 - - VBN cord-005453-4057qib7 11084 7 assessed assess VBN cord-005453-4057qib7 11084 8 by by IN cord-005453-4057qib7 11084 9 PET PET NNP cord-005453-4057qib7 11084 10 / / SYM cord-005453-4057qib7 11084 11 CT CT NNP cord-005453-4057qib7 11084 12 scan scan NN cord-005453-4057qib7 11084 13 . . . cord-005453-4057qib7 11085 1 The the DT cord-005453-4057qib7 11085 2 overall overall JJ cord-005453-4057qib7 11085 3 response response NN cord-005453-4057qib7 11085 4 rate rate NN cord-005453-4057qib7 11085 5 ( ( -LRB- cord-005453-4057qib7 11085 6 > > NFP cord-005453-4057qib7 11085 7 50 50 CD cord-005453-4057qib7 11085 8 % % NN cord-005453-4057qib7 11085 9 tumor tumor NN cord-005453-4057qib7 11085 10 reduction reduction NN cord-005453-4057qib7 11085 11 ) ) -RRB- cord-005453-4057qib7 11085 12 was be VBD cord-005453-4057qib7 11085 13 significantly significantly RB cord-005453-4057qib7 11085 14 superior superior JJ cord-005453-4057qib7 11085 15 for for IN cord-005453-4057qib7 11085 16 the the DT cord-005453-4057qib7 11085 17 DICEP DICEP NNP cord-005453-4057qib7 11085 18 - - HYPH cord-005453-4057qib7 11085 19 regimen regimen NN cord-005453-4057qib7 11085 20 , , , cord-005453-4057qib7 11085 21 reaching reach VBG cord-005453-4057qib7 11085 22 92 92 CD cord-005453-4057qib7 11085 23 % % NN cord-005453-4057qib7 11085 24 ( ( -LRB- cord-005453-4057qib7 11085 25 21/23 21/23 CD cord-005453-4057qib7 11085 26 patients patient NNS cord-005453-4057qib7 11085 27 ) ) -RRB- cord-005453-4057qib7 11085 28 vs. vs. IN cord-005453-4057qib7 11085 29 64 64 CD cord-005453-4057qib7 11085 30 % % NN cord-005453-4057qib7 11085 31 ( ( -LRB- cord-005453-4057qib7 11085 32 27/44 27/44 CD cord-005453-4057qib7 11085 33 patients patient NNS cord-005453-4057qib7 11085 34 ) ) -RRB- cord-005453-4057qib7 11085 35 for for IN cord-005453-4057qib7 11085 36 ESHAPregimen ESHAPregimen NNP cord-005453-4057qib7 11085 37 ( ( -LRB- cord-005453-4057qib7 11085 38 p=0,003 p=0,003 NN cord-005453-4057qib7 11085 39 ) ) -RRB- cord-005453-4057qib7 11085 40 . . . cord-005453-4057qib7 11086 1 Eleven eleven CD cord-005453-4057qib7 11086 2 patients patient NNS cord-005453-4057qib7 11086 3 ( ( -LRB- cord-005453-4057qib7 11086 4 48 48 CD cord-005453-4057qib7 11086 5 % % NN cord-005453-4057qib7 11086 6 ) ) -RRB- cord-005453-4057qib7 11086 7 from from IN cord-005453-4057qib7 11086 8 the the DT cord-005453-4057qib7 11086 9 DICEP DICEP NNP cord-005453-4057qib7 11086 10 - - HYPH cord-005453-4057qib7 11086 11 group group NN cord-005453-4057qib7 11086 12 and and CC cord-005453-4057qib7 11086 13 14(30 14(30 CD cord-005453-4057qib7 11086 14 % % NN cord-005453-4057qib7 11086 15 ) ) -RRB- cord-005453-4057qib7 11086 16 from from IN cord-005453-4057qib7 11086 17 the the DT cord-005453-4057qib7 11086 18 ESHAP ESHAP NNP cord-005453-4057qib7 11086 19 - - HYPH cord-005453-4057qib7 11086 20 group group NN cord-005453-4057qib7 11086 21 achieved achieve VBD cord-005453-4057qib7 11086 22 complete complete JJ cord-005453-4057qib7 11086 23 metabolic metabolic JJ cord-005453-4057qib7 11086 24 remission remission NN cord-005453-4057qib7 11086 25 according accord VBG cord-005453-4057qib7 11086 26 to to IN cord-005453-4057qib7 11086 27 PET/ PET/ NNP cord-005453-4057qib7 11086 28 CT CT NNP cord-005453-4057qib7 11086 29 criteria criterion NNS cord-005453-4057qib7 11086 30 ( ( -LRB- cord-005453-4057qib7 11086 31 p p NN cord-005453-4057qib7 11086 32 = = SYM cord-005453-4057qib7 11086 33 ns ns NNP cord-005453-4057qib7 11086 34 ) ) -RRB- cord-005453-4057qib7 11086 35 . . . cord-005453-4057qib7 11087 1 The the DT cord-005453-4057qib7 11087 2 median median JJ cord-005453-4057qib7 11087 3 hospitalization hospitalization NN cord-005453-4057qib7 11087 4 period period NN cord-005453-4057qib7 11087 5 was be VBD cord-005453-4057qib7 11087 6 20(5 20(5 CD cord-005453-4057qib7 11087 7 - - SYM cord-005453-4057qib7 11087 8 25 25 CD cord-005453-4057qib7 11087 9 ) ) -RRB- cord-005453-4057qib7 11087 10 days day NNS cord-005453-4057qib7 11087 11 for for IN cord-005453-4057qib7 11087 12 the the DT cord-005453-4057qib7 11087 13 DICEP DICEP NNP cord-005453-4057qib7 11087 14 - - HYPH cord-005453-4057qib7 11087 15 group group NN cord-005453-4057qib7 11087 16 compared compare VBN cord-005453-4057qib7 11087 17 to to IN cord-005453-4057qib7 11087 18 10(10 10(10 CD cord-005453-4057qib7 11087 19 - - SYM cord-005453-4057qib7 11087 20 19 19 CD cord-005453-4057qib7 11087 21 ) ) -RRB- cord-005453-4057qib7 11087 22 days day NNS cord-005453-4057qib7 11087 23 for for IN cord-005453-4057qib7 11087 24 the the DT cord-005453-4057qib7 11087 25 ESHAP ESHAP NNP cord-005453-4057qib7 11087 26 - - HYPH cord-005453-4057qib7 11087 27 group group NN cord-005453-4057qib7 11087 28 . . . cord-005453-4057qib7 11088 1 However however RB cord-005453-4057qib7 11088 2 , , , cord-005453-4057qib7 11088 3 for for IN cord-005453-4057qib7 11088 4 the the DT cord-005453-4057qib7 11088 5 ESHAPgroup eshapgroup NN cord-005453-4057qib7 11088 6 , , , cord-005453-4057qib7 11088 7 an an DT cord-005453-4057qib7 11088 8 additional additional JJ cord-005453-4057qib7 11088 9 median median NN cord-005453-4057qib7 11088 10 of of IN cord-005453-4057qib7 11088 11 20(6 20(6 CD cord-005453-4057qib7 11088 12 - - SYM cord-005453-4057qib7 11088 13 33 33 CD cord-005453-4057qib7 11088 14 ) ) -RRB- cord-005453-4057qib7 11088 15 hospitalization hospitalization NN cord-005453-4057qib7 11088 16 days day NNS cord-005453-4057qib7 11088 17 were be VBD cord-005453-4057qib7 11088 18 required require VBN cord-005453-4057qib7 11088 19 , , , cord-005453-4057qib7 11088 20 since since IN cord-005453-4057qib7 11088 21 12 12 CD cord-005453-4057qib7 11088 22 of of IN cord-005453-4057qib7 11088 23 the the DT cord-005453-4057qib7 11088 24 non non NNS cord-005453-4057qib7 11088 25 - - NNS cord-005453-4057qib7 11088 26 responders responder NNS cord-005453-4057qib7 11088 27 patients patient NNS cord-005453-4057qib7 11088 28 received receive VBD cord-005453-4057qib7 11088 29 a a DT cord-005453-4057qib7 11088 30 2 2 CD cord-005453-4057qib7 11088 31 nd nd NNP cord-005453-4057qib7 11088 32 salvage salvage NN cord-005453-4057qib7 11088 33 before before IN cord-005453-4057qib7 11088 34 ASCT ASCT NNP cord-005453-4057qib7 11088 35 . . . cord-005453-4057qib7 11089 1 The the DT cord-005453-4057qib7 11089 2 mobilization mobilization NN cord-005453-4057qib7 11089 3 and and CC cord-005453-4057qib7 11089 4 stem stem NN cord-005453-4057qib7 11089 5 cell cell NN cord-005453-4057qib7 11089 6 collection collection NN cord-005453-4057qib7 11089 7 was be VBD cord-005453-4057qib7 11089 8 successful successful JJ cord-005453-4057qib7 11089 9 for for IN cord-005453-4057qib7 11089 10 both both DT cord-005453-4057qib7 11089 11 groups group NNS cord-005453-4057qib7 11089 12 , , , cord-005453-4057qib7 11089 13 though though IN cord-005453-4057qib7 11089 14 significant significant JJ cord-005453-4057qib7 11089 15 higher high JJR cord-005453-4057qib7 11089 16 number number NN cord-005453-4057qib7 11089 17 of of IN cord-005453-4057qib7 11089 18 CD34 CD34 NNP cord-005453-4057qib7 11089 19 + + CC cord-005453-4057qib7 11089 20 cells cell NNS cord-005453-4057qib7 11089 21 were be VBD cord-005453-4057qib7 11089 22 collected collect VBN cord-005453-4057qib7 11089 23 in in IN cord-005453-4057qib7 11089 24 the the DT cord-005453-4057qib7 11089 25 DICEP DICEP NNP cord-005453-4057qib7 11089 26 - - HYPH cord-005453-4057qib7 11089 27 group group NN cord-005453-4057qib7 11089 28 ( ( -LRB- cord-005453-4057qib7 11089 29 17.2x10 17.2x10 CD cord-005453-4057qib7 11089 30 3 3 CD cord-005453-4057qib7 11089 31 /kg /kg . cord-005453-4057qib7 11089 32 vs. vs. FW cord-005453-4057qib7 11089 33 5.4x10 5.4x10 CD cord-005453-4057qib7 11089 34 3 3 CD cord-005453-4057qib7 11090 1 /kg /kg NFP cord-005453-4057qib7 11090 2 , , , cord-005453-4057qib7 11090 3 p=0,001 p=0,001 NNP cord-005453-4057qib7 11090 4 ) ) -RRB- cord-005453-4057qib7 11090 5 . . . cord-005453-4057qib7 11091 1 All all DT cord-005453-4057qib7 11091 2 but but IN cord-005453-4057qib7 11091 3 two two CD cord-005453-4057qib7 11091 4 patients patient NNS cord-005453-4057qib7 11091 5 ( ( -LRB- cord-005453-4057qib7 11091 6 due due IN cord-005453-4057qib7 11091 7 to to IN cord-005453-4057qib7 11091 8 refractory refractory JJ cord-005453-4057qib7 11091 9 disease disease NN cord-005453-4057qib7 11091 10 ) ) -RRB- cord-005453-4057qib7 11091 11 underwent undergo VBD cord-005453-4057qib7 11091 12 ASCT ASCT NNP cord-005453-4057qib7 11091 13 . . . cord-005453-4057qib7 11092 1 Noticeably noticeably RB cord-005453-4057qib7 11092 2 , , , cord-005453-4057qib7 11092 3 the the DT cord-005453-4057qib7 11092 4 median median JJ cord-005453-4057qib7 11092 5 period period NN cord-005453-4057qib7 11092 6 from from IN cord-005453-4057qib7 11092 7 1 1 CD cord-005453-4057qib7 11092 8 st st NNP cord-005453-4057qib7 11092 9 salvage salvage NN cord-005453-4057qib7 11092 10 treatment treatment NN cord-005453-4057qib7 11092 11 to to IN cord-005453-4057qib7 11092 12 ASCT ASCT NNP cord-005453-4057qib7 11092 13 was be VBD cord-005453-4057qib7 11092 14 significantly significantly RB cord-005453-4057qib7 11092 15 shorter short JJR cord-005453-4057qib7 11092 16 for for IN cord-005453-4057qib7 11092 17 the the DT cord-005453-4057qib7 11092 18 DICEPgroup dicepgroup NN cord-005453-4057qib7 11092 19 ( ( -LRB- cord-005453-4057qib7 11092 20 64 64 CD cord-005453-4057qib7 11092 21 vs. vs. IN cord-005453-4057qib7 11092 22 128 128 CD cord-005453-4057qib7 11092 23 days day NNS cord-005453-4057qib7 11092 24 , , , cord-005453-4057qib7 11092 25 p=0,013 p=0,013 NNP cord-005453-4057qib7 11092 26 ) ) -RRB- cord-005453-4057qib7 11092 27 , , , cord-005453-4057qib7 11092 28 apparently apparently RB cord-005453-4057qib7 11092 29 because because IN cord-005453-4057qib7 11092 30 12 12 CD cord-005453-4057qib7 11092 31 non non NNS cord-005453-4057qib7 11092 32 - - NNS cord-005453-4057qib7 11092 33 responders responder NNS cord-005453-4057qib7 11092 34 patients patient NNS cord-005453-4057qib7 11092 35 from from IN cord-005453-4057qib7 11092 36 ESHAP ESHAP NNP cord-005453-4057qib7 11092 37 - - HYPH cord-005453-4057qib7 11092 38 group group NN cord-005453-4057qib7 11092 39 treated treat VBN cord-005453-4057qib7 11092 40 with with IN cord-005453-4057qib7 11092 41 a a DT cord-005453-4057qib7 11092 42 2 2 CD cord-005453-4057qib7 11092 43 nd nd NNP cord-005453-4057qib7 11092 44 salvage salvage NN cord-005453-4057qib7 11092 45 . . . cord-005453-4057qib7 11093 1 The the DT cord-005453-4057qib7 11093 2 3-years 3-years CD cord-005453-4057qib7 11093 3 overall overall JJ cord-005453-4057qib7 11093 4 and and CC cord-005453-4057qib7 11093 5 progression progression NN cord-005453-4057qib7 11093 6 free free JJ cord-005453-4057qib7 11093 7 survival survival NN cord-005453-4057qib7 11093 8 were be VBD cord-005453-4057qib7 11093 9 similar similar JJ cord-005453-4057qib7 11093 10 for for IN cord-005453-4057qib7 11093 11 DICEP DICEP NNP cord-005453-4057qib7 11093 12 - - : cord-005453-4057qib7 11093 13 and and CC cord-005453-4057qib7 11093 14 ESHAP ESHAP NNP cord-005453-4057qib7 11093 15 - - HYPH cord-005453-4057qib7 11093 16 groups group NNS cord-005453-4057qib7 11093 17 ( ( -LRB- cord-005453-4057qib7 11093 18 95 95 CD cord-005453-4057qib7 11093 19 % % NN cord-005453-4057qib7 11093 20 vs. vs. IN cord-005453-4057qib7 11093 21 88 88 CD cord-005453-4057qib7 11093 22 % % NN cord-005453-4057qib7 11093 23 and and CC cord-005453-4057qib7 11093 24 70 70 CD cord-005453-4057qib7 11093 25 % % NN cord-005453-4057qib7 11093 26 vs vs IN cord-005453-4057qib7 11093 27 80 80 CD cord-005453-4057qib7 11093 28 % % NN cord-005453-4057qib7 11093 29 respectively respectively RB cord-005453-4057qib7 11093 30 ) ) -RRB- cord-005453-4057qib7 11093 31 . . . cord-005453-4057qib7 11094 1 Two two CD cord-005453-4057qib7 11094 2 heavily heavily RB cord-005453-4057qib7 11094 3 pretreated pretreate VBD cord-005453-4057qib7 11094 4 patients patient NNS cord-005453-4057qib7 11094 5 from from IN cord-005453-4057qib7 11094 6 the the DT cord-005453-4057qib7 11094 7 ESHAP ESHAP NNP cord-005453-4057qib7 11094 8 - - HYPH cord-005453-4057qib7 11094 9 group group NN cord-005453-4057qib7 11094 10 developed develop VBD cord-005453-4057qib7 11094 11 secondary secondary JJ cord-005453-4057qib7 11094 12 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 11094 13 syndrome syndrome NN cord-005453-4057qib7 11094 14 post post NN cord-005453-4057qib7 11094 15 ASCT ASCT NNP cord-005453-4057qib7 11094 16 Conclusions Conclusions NNPS cord-005453-4057qib7 11094 17 : : : cord-005453-4057qib7 11095 1 In in IN cord-005453-4057qib7 11095 2 our -PRON- PRP$ cord-005453-4057qib7 11095 3 series series NN cord-005453-4057qib7 11095 4 of of IN cord-005453-4057qib7 11095 5 patients patient NNS cord-005453-4057qib7 11095 6 both both DT cord-005453-4057qib7 11095 7 regimens regimen NNS cord-005453-4057qib7 11095 8 proved prove VBD cord-005453-4057qib7 11095 9 to to TO cord-005453-4057qib7 11095 10 be be VB cord-005453-4057qib7 11095 11 safe safe JJ cord-005453-4057qib7 11095 12 . . . cord-005453-4057qib7 11096 1 Interestingly interestingly RB cord-005453-4057qib7 11096 2 , , , cord-005453-4057qib7 11096 3 despite despite IN cord-005453-4057qib7 11096 4 the the DT cord-005453-4057qib7 11096 5 fact fact NN cord-005453-4057qib7 11096 6 that that IN cord-005453-4057qib7 11096 7 more more JJR cord-005453-4057qib7 11096 8 patients patient NNS cord-005453-4057qib7 11096 9 in in IN cord-005453-4057qib7 11096 10 DICEP DICEP NNP cord-005453-4057qib7 11096 11 - - HYPH cord-005453-4057qib7 11096 12 group group NN cord-005453-4057qib7 11096 13 had have VBD cord-005453-4057qib7 11096 14 poor poor JJ cord-005453-4057qib7 11096 15 risk risk NN cord-005453-4057qib7 11096 16 disease disease NN cord-005453-4057qib7 11097 1 the the DT cord-005453-4057qib7 11097 2 DICEPregiment dicepregiment NN cord-005453-4057qib7 11097 3 was be VBD cord-005453-4057qib7 11097 4 significantly significantly RB cord-005453-4057qib7 11097 5 more more RBR cord-005453-4057qib7 11097 6 effective effective JJ cord-005453-4057qib7 11097 7 , , , cord-005453-4057qib7 11097 8 resulting result VBG cord-005453-4057qib7 11097 9 thus thus RB cord-005453-4057qib7 11097 10 in in IN cord-005453-4057qib7 11097 11 an an DT cord-005453-4057qib7 11097 12 earlier early JJR cord-005453-4057qib7 11097 13 ASCT ASCT NNP cord-005453-4057qib7 11097 14 , , , cord-005453-4057qib7 11097 15 less less JJR cord-005453-4057qib7 11097 16 exposure exposure NN cord-005453-4057qib7 11097 17 to to IN cord-005453-4057qib7 11097 18 chemotherapeutic chemotherapeutic JJ cord-005453-4057qib7 11097 19 agents agent NNS cord-005453-4057qib7 11097 20 , , , cord-005453-4057qib7 11097 21 that that WDT cord-005453-4057qib7 11097 22 might may MD cord-005453-4057qib7 11097 23 led lead VBD cord-005453-4057qib7 11097 24 in in IN cord-005453-4057qib7 11097 25 less less JJR cord-005453-4057qib7 11097 26 long long JJ cord-005453-4057qib7 11097 27 - - HYPH cord-005453-4057qib7 11097 28 term term NN cord-005453-4057qib7 11097 29 toxicity toxicity NN cord-005453-4057qib7 11097 30 . . . cord-005453-4057qib7 11098 1 Nevertheless nevertheless RB cord-005453-4057qib7 11098 2 , , , cord-005453-4057qib7 11098 3 prospective prospective JJ cord-005453-4057qib7 11098 4 trials trial NNS cord-005453-4057qib7 11098 5 with with IN cord-005453-4057qib7 11098 6 large large JJ cord-005453-4057qib7 11098 7 series series NN cord-005453-4057qib7 11098 8 of of IN cord-005453-4057qib7 11098 9 patients patient NNS cord-005453-4057qib7 11098 10 are be VBP cord-005453-4057qib7 11098 11 needed need VBN cord-005453-4057qib7 11098 12 to to TO cord-005453-4057qib7 11098 13 define define VB cord-005453-4057qib7 11098 14 the the DT cord-005453-4057qib7 11098 15 role role NN cord-005453-4057qib7 11098 16 of of IN cord-005453-4057qib7 11098 17 DICEP DICEP NNP cord-005453-4057qib7 11098 18 in in IN cord-005453-4057qib7 11098 19 the the DT cord-005453-4057qib7 11098 20 salvage salvage NN cord-005453-4057qib7 11098 21 treatment treatment NN cord-005453-4057qib7 11098 22 setting setting NN cord-005453-4057qib7 11098 23 . . . cord-005453-4057qib7 11099 1 Disclosure disclosure NN cord-005453-4057qib7 11099 2 : : : cord-005453-4057qib7 11099 3 no no DT cord-005453-4057qib7 11099 4 conflict conflict NN cord-005453-4057qib7 11099 5 of of IN cord-005453-4057qib7 11099 6 interest interest NN cord-005453-4057qib7 11099 7 Background background NN cord-005453-4057qib7 11099 8 : : : cord-005453-4057qib7 11100 1 Although although IN cord-005453-4057qib7 11100 2 autologous autologous JJ cord-005453-4057qib7 11100 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 11100 4 stem stem NN cord-005453-4057qib7 11100 5 cell cell NN cord-005453-4057qib7 11100 6 transplantation transplantation NN cord-005453-4057qib7 11100 7 ( ( -LRB- cord-005453-4057qib7 11100 8 auto auto NN cord-005453-4057qib7 11100 9 - - HYPH cord-005453-4057qib7 11100 10 HSCT HSCT NNP cord-005453-4057qib7 11100 11 ) ) -RRB- cord-005453-4057qib7 11100 12 is be VBZ cord-005453-4057qib7 11100 13 one one CD cord-005453-4057qib7 11100 14 of of IN cord-005453-4057qib7 11100 15 the the DT cord-005453-4057qib7 11100 16 best good JJS cord-005453-4057qib7 11100 17 curative curative JJ cord-005453-4057qib7 11100 18 strategies strategy NNS cord-005453-4057qib7 11100 19 for for IN cord-005453-4057qib7 11100 20 patients patient NNS cord-005453-4057qib7 11100 21 with with IN cord-005453-4057qib7 11100 22 chemosensitive chemosensitive JJ cord-005453-4057qib7 11100 23 T t NN cord-005453-4057qib7 11100 24 - - HYPH cord-005453-4057qib7 11100 25 cell cell NN cord-005453-4057qib7 11100 26 lymphoma lymphoma NN cord-005453-4057qib7 11100 27 , , , cord-005453-4057qib7 11100 28 major major JJ cord-005453-4057qib7 11100 29 limitation limitation NN cord-005453-4057qib7 11100 30 remains remain VBZ cord-005453-4057qib7 11100 31 a a DT cord-005453-4057qib7 11100 32 tumor tumor NN cord-005453-4057qib7 11100 33 contaminated contaminate VBN cord-005453-4057qib7 11100 34 graft graft NN cord-005453-4057qib7 11100 35 - - HYPH cord-005453-4057qib7 11100 36 related relate VBN cord-005453-4057qib7 11100 37 relapse relapse NN cord-005453-4057qib7 11100 38 or or CC cord-005453-4057qib7 11100 39 residual residual JJ cord-005453-4057qib7 11100 40 disease disease NN cord-005453-4057qib7 11100 41 after after IN cord-005453-4057qib7 11100 42 chemotherapy chemotherapy NN cord-005453-4057qib7 11100 43 . . . cord-005453-4057qib7 11101 1 Several several JJ cord-005453-4057qib7 11101 2 purging purging NN cord-005453-4057qib7 11101 3 methods method NNS cord-005453-4057qib7 11101 4 were be VBD cord-005453-4057qib7 11101 5 introduced introduce VBN cord-005453-4057qib7 11101 6 in in IN cord-005453-4057qib7 11101 7 auto auto NN cord-005453-4057qib7 11101 8 - - HYPH cord-005453-4057qib7 11101 9 HSCT HSCT NNP cord-005453-4057qib7 11101 10 for for IN cord-005453-4057qib7 11101 11 these these DT cord-005453-4057qib7 11101 12 limitations limitation NNS cord-005453-4057qib7 11101 13 , , , cord-005453-4057qib7 11101 14 however however RB cord-005453-4057qib7 11101 15 there there EX cord-005453-4057qib7 11101 16 are be VBP cord-005453-4057qib7 11101 17 few few JJ cord-005453-4057qib7 11101 18 studies study NNS cord-005453-4057qib7 11101 19 of of IN cord-005453-4057qib7 11101 20 ex ex NNP cord-005453-4057qib7 11101 21 vivo vivo NN cord-005453-4057qib7 11101 22 purging purging NN cord-005453-4057qib7 11101 23 of of IN cord-005453-4057qib7 11101 24 the the DT cord-005453-4057qib7 11101 25 autograft autograft NN cord-005453-4057qib7 11101 26 in in IN cord-005453-4057qib7 11101 27 lymphomas lymphoma NNS cord-005453-4057qib7 11101 28 , , , cord-005453-4057qib7 11101 29 especially especially RB cord-005453-4057qib7 11101 30 T t NN cord-005453-4057qib7 11101 31 - - HYPH cord-005453-4057qib7 11101 32 cell cell NN cord-005453-4057qib7 11101 33 lymphoma lymphoma NN cord-005453-4057qib7 11101 34 . . . cord-005453-4057qib7 11102 1 Therefore therefore RB cord-005453-4057qib7 11102 2 , , , cord-005453-4057qib7 11102 3 we -PRON- PRP cord-005453-4057qib7 11102 4 retrospectively retrospectively RB cord-005453-4057qib7 11102 5 analyzed analyze VBD cord-005453-4057qib7 11102 6 59 59 CD cord-005453-4057qib7 11102 7 consecutive consecutive JJ cord-005453-4057qib7 11102 8 T t NN cord-005453-4057qib7 11102 9 - - HYPH cord-005453-4057qib7 11102 10 cell cell NN cord-005453-4057qib7 11102 11 lymphoma lymphoma NN cord-005453-4057qib7 11102 12 patients patient NNS cord-005453-4057qib7 11102 13 receiving receive VBG cord-005453-4057qib7 11102 14 auto auto NN cord-005453-4057qib7 11102 15 - - HYPH cord-005453-4057qib7 11102 16 HSCT HSCT NNP cord-005453-4057qib7 11102 17 with with IN cord-005453-4057qib7 11102 18 / / SYM cord-005453-4057qib7 11102 19 without without IN cord-005453-4057qib7 11102 20 ex ex FW cord-005453-4057qib7 11102 21 vivo vivo NN cord-005453-4057qib7 11102 22 purging purging NN cord-005453-4057qib7 11102 23 . . . cord-005453-4057qib7 11103 1 Methods method NNS cord-005453-4057qib7 11103 2 : : : cord-005453-4057qib7 11104 1 Among among IN cord-005453-4057qib7 11104 2 them -PRON- PRP cord-005453-4057qib7 11104 3 , , , cord-005453-4057qib7 11104 4 33 33 CD cord-005453-4057qib7 11104 5 patients patient NNS cord-005453-4057qib7 11104 6 underwent undergo VBD cord-005453-4057qib7 11104 7 autograft autograft NN cord-005453-4057qib7 11104 8 manipulation manipulation NN cord-005453-4057qib7 11104 9 with with IN cord-005453-4057qib7 11104 10 ex ex FW cord-005453-4057qib7 11104 11 vivo vivo NN cord-005453-4057qib7 11104 12 purging purge VBG cord-005453-4057qib7 11104 13 by by IN cord-005453-4057qib7 11104 14 CD34 CD34 NNP cord-005453-4057qib7 11104 15 + + CC cord-005453-4057qib7 11104 16 cells cell NNS cord-005453-4057qib7 11104 17 selection selection NN cord-005453-4057qib7 11104 18 using use VBG cord-005453-4057qib7 11104 19 a a DT cord-005453-4057qib7 11104 20 CliniMACS CliniMACS NNP cord-005453-4057qib7 11104 21 device device NN cord-005453-4057qib7 11104 22 . . . cord-005453-4057qib7 11105 1 Results result NNS cord-005453-4057qib7 11105 2 : : : cord-005453-4057qib7 11106 1 With with IN cord-005453-4057qib7 11106 2 median median JJ cord-005453-4057qib7 11106 3 follow follow NN cord-005453-4057qib7 11106 4 - - HYPH cord-005453-4057qib7 11106 5 up up NN cord-005453-4057qib7 11106 6 duration duration NN cord-005453-4057qib7 11106 7 of of IN cord-005453-4057qib7 11106 8 42 42 CD cord-005453-4057qib7 11106 9 months month NNS cord-005453-4057qib7 11106 10 ( ( -LRB- cord-005453-4057qib7 11106 11 range range NN cord-005453-4057qib7 11106 12 , , , cord-005453-4057qib7 11106 13 6 6 CD cord-005453-4057qib7 11106 14 - - SYM cord-005453-4057qib7 11106 15 121 121 CD cord-005453-4057qib7 11106 16 months month NNS cord-005453-4057qib7 11106 17 ) ) -RRB- cord-005453-4057qib7 11106 18 , , , cord-005453-4057qib7 11106 19 3-year 3-year JJ cord-005453-4057qib7 11106 20 overall overall JJ cord-005453-4057qib7 11106 21 survival survival NN cord-005453-4057qib7 11106 22 ( ( -LRB- cord-005453-4057qib7 11106 23 OS os NN cord-005453-4057qib7 11106 24 ; ; : cord-005453-4057qib7 11106 25 73.8 73.8 CD cord-005453-4057qib7 11106 26 % % NN cord-005453-4057qib7 11106 27 vs. vs. NN cord-005453-4057qib7 11106 28 49.0 49.0 CD cord-005453-4057qib7 11106 29 % % NN cord-005453-4057qib7 11106 30 , , , cord-005453-4057qib7 11106 31 p=0.017 p=0.017 NNS cord-005453-4057qib7 11106 32 ) ) -RRB- cord-005453-4057qib7 11106 33 and and CC cord-005453-4057qib7 11106 34 3-year 3-year CD cord-005453-4057qib7 11106 35 progression progression NN cord-005453-4057qib7 11106 36 - - HYPH cord-005453-4057qib7 11106 37 free free JJ cord-005453-4057qib7 11106 38 survival survival NN cord-005453-4057qib7 11106 39 ( ( -LRB- cord-005453-4057qib7 11106 40 PFS PFS NNP cord-005453-4057qib7 11106 41 ; ; : cord-005453-4057qib7 11106 42 75.8 75.8 CD cord-005453-4057qib7 11106 43 % % NN cord-005453-4057qib7 11106 44 vs. vs. CC cord-005453-4057qib7 11106 45 52.4 52.4 CD cord-005453-4057qib7 11106 46 % % NN cord-005453-4057qib7 11106 47 , , , cord-005453-4057qib7 11106 48 p=0.039 p=0.039 JJ cord-005453-4057qib7 11106 49 ) ) -RRB- cord-005453-4057qib7 11106 50 in in IN cord-005453-4057qib7 11106 51 a a DT cord-005453-4057qib7 11106 52 purged purge VBN cord-005453-4057qib7 11106 53 and and CC cord-005453-4057qib7 11106 54 unpurged unpurged JJ cord-005453-4057qib7 11106 55 group group NN cord-005453-4057qib7 11106 56 , , , cord-005453-4057qib7 11106 57 respectively respectively RB cord-005453-4057qib7 11106 58 . . . cord-005453-4057qib7 11107 1 Transplant transplant NN cord-005453-4057qib7 11107 2 - - HYPH cord-005453-4057qib7 11107 3 related relate VBN cord-005453-4057qib7 11107 4 mortality mortality NN cord-005453-4057qib7 11107 5 was be VBD cord-005453-4057qib7 11107 6 observed observe VBN cord-005453-4057qib7 11107 7 in in IN cord-005453-4057qib7 11107 8 both both DT cord-005453-4057qib7 11107 9 groups group NNS cord-005453-4057qib7 11107 10 ( ( -LRB- cord-005453-4057qib7 11107 11 2 2 CD cord-005453-4057qib7 11107 12 patients patient NNS cord-005453-4057qib7 11107 13 of of IN cord-005453-4057qib7 11107 14 a a DT cord-005453-4057qib7 11107 15 purged purge VBN cord-005453-4057qib7 11107 16 group group NN cord-005453-4057qib7 11107 17 and and CC cord-005453-4057qib7 11107 18 1 1 CD cord-005453-4057qib7 11107 19 patient patient NN cord-005453-4057qib7 11107 20 of of IN cord-005453-4057qib7 11107 21 an an DT cord-005453-4057qib7 11107 22 unpurged unpurged JJ cord-005453-4057qib7 11107 23 group group NN cord-005453-4057qib7 11107 24 ) ) -RRB- cord-005453-4057qib7 11107 25 . . . cord-005453-4057qib7 11108 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 11108 2 ( ( -LRB- cord-005453-4057qib7 11108 3 10 10 CD cord-005453-4057qib7 11108 4 vs. vs. NN cord-005453-4057qib7 11108 5 9 9 CD cord-005453-4057qib7 11108 6 days day NNS cord-005453-4057qib7 11108 7 , , , cord-005453-4057qib7 11108 8 p=0.240 p=0.240 NNP cord-005453-4057qib7 11108 9 ) ) -RRB- cord-005453-4057qib7 11109 1 and and CC cord-005453-4057qib7 11109 2 platelet platelet NN cord-005453-4057qib7 11109 3 ( ( -LRB- cord-005453-4057qib7 11109 4 30 30 CD cord-005453-4057qib7 11109 5 vs. vs. NN cord-005453-4057qib7 11109 6 24 24 CD cord-005453-4057qib7 11109 7 days day NNS cord-005453-4057qib7 11109 8 , , , cord-005453-4057qib7 11109 9 p=0.055 p=0.055 NN cord-005453-4057qib7 11109 10 ) ) -RRB- cord-005453-4057qib7 11109 11 recovery recovery NN cord-005453-4057qib7 11109 12 were be VBD cord-005453-4057qib7 11109 13 similar similar JJ cord-005453-4057qib7 11109 14 in in IN cord-005453-4057qib7 11109 15 both both DT cord-005453-4057qib7 11109 16 group group NN cord-005453-4057qib7 11109 17 and and CC cord-005453-4057qib7 11109 18 there there EX cord-005453-4057qib7 11109 19 was be VBD cord-005453-4057qib7 11109 20 no no DT cord-005453-4057qib7 11109 21 engraftment engraftment NN cord-005453-4057qib7 11109 22 failure failure NN cord-005453-4057qib7 11109 23 . . . cord-005453-4057qib7 11110 1 On on IN cord-005453-4057qib7 11110 2 subgroup subgroup NN cord-005453-4057qib7 11110 3 analysis analysis NN cord-005453-4057qib7 11110 4 according accord VBG cord-005453-4057qib7 11110 5 to to IN cord-005453-4057qib7 11110 6 upfront upfront NN cord-005453-4057qib7 11110 7 and and CC cord-005453-4057qib7 11110 8 salvage salvage VB cord-005453-4057qib7 11110 9 auto auto NN cord-005453-4057qib7 11110 10 - - HYPH cord-005453-4057qib7 11110 11 HSCT HSCT NNP cord-005453-4057qib7 11110 12 , , , cord-005453-4057qib7 11110 13 while while IN cord-005453-4057qib7 11110 14 survival survival NN cord-005453-4057qib7 11110 15 outcomes outcome NNS cord-005453-4057qib7 11110 16 were be VBD cord-005453-4057qib7 11110 17 improved improve VBN cord-005453-4057qib7 11110 18 by by IN cord-005453-4057qib7 11110 19 stem stem NN cord-005453-4057qib7 11110 20 cell cell NN cord-005453-4057qib7 11110 21 purging purge VBG cord-005453-4057qib7 11110 22 in in IN cord-005453-4057qib7 11110 23 the the DT cord-005453-4057qib7 11110 24 upfront upfront JJ cord-005453-4057qib7 11110 25 auto auto NN cord-005453-4057qib7 11110 26 - - HYPH cord-005453-4057qib7 11110 27 HSCT HSCT NNP cord-005453-4057qib7 11110 28 ( ( -LRB- cord-005453-4057qib7 11110 29 OS OS NNP cord-005453-4057qib7 11110 30 with with IN cord-005453-4057qib7 11110 31 p=0.039 p=0.039 JJ cord-005453-4057qib7 11110 32 and and CC cord-005453-4057qib7 11110 33 PFS PFS NNP cord-005453-4057qib7 11110 34 with with IN cord-005453-4057qib7 11110 35 p=0.047 p=0.047 NNS cord-005453-4057qib7 11110 36 ) ) -RRB- cord-005453-4057qib7 11110 37 , , , cord-005453-4057qib7 11110 38 there there EX cord-005453-4057qib7 11110 39 were be VBD cord-005453-4057qib7 11110 40 no no DT cord-005453-4057qib7 11110 41 different different JJ cord-005453-4057qib7 11110 42 survival survival NN cord-005453-4057qib7 11110 43 outcomes outcome NNS cord-005453-4057qib7 11110 44 in in IN cord-005453-4057qib7 11110 45 salvage salvage NN cord-005453-4057qib7 11110 46 auto auto NN cord-005453-4057qib7 11110 47 - - HYPH cord-005453-4057qib7 11110 48 HSCT HSCT NNP cord-005453-4057qib7 11110 49 . . . cord-005453-4057qib7 11111 1 The the DT cord-005453-4057qib7 11111 2 unmanageable unmanageable JJ cord-005453-4057qib7 11111 3 late late JJ cord-005453-4057qib7 11111 4 - - HYPH cord-005453-4057qib7 11111 5 infectious infectious JJ cord-005453-4057qib7 11111 6 complications complication NNS cord-005453-4057qib7 11111 7 were be VBD cord-005453-4057qib7 11111 8 few few JJ cord-005453-4057qib7 11111 9 in in IN cord-005453-4057qib7 11111 10 both both DT cord-005453-4057qib7 11111 11 groups group NNS cord-005453-4057qib7 11111 12 except except IN cord-005453-4057qib7 11111 13 for for IN cord-005453-4057qib7 11111 14 predominantly predominantly RB cord-005453-4057qib7 11111 15 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 11111 16 reactivation reactivation NN cord-005453-4057qib7 11111 17 in in IN cord-005453-4057qib7 11111 18 a a DT cord-005453-4057qib7 11111 19 purged purge VBN cord-005453-4057qib7 11111 20 group group NN cord-005453-4057qib7 11111 21 ( ( -LRB- cord-005453-4057qib7 11111 22 3 3 CD cord-005453-4057qib7 11111 23 vs. vs. NN cord-005453-4057qib7 11111 24 1 1 CD cord-005453-4057qib7 11111 25 patient patient NN cord-005453-4057qib7 11111 26 ) ) -RRB- cord-005453-4057qib7 11111 27 . . . cord-005453-4057qib7 11112 1 Conclusions conclusion NNS cord-005453-4057qib7 11112 2 : : : cord-005453-4057qib7 11113 1 Although although IN cord-005453-4057qib7 11113 2 cohort cohort NN cord-005453-4057qib7 11113 3 was be VBD cord-005453-4057qib7 11113 4 a a DT cord-005453-4057qib7 11113 5 small small JJ cord-005453-4057qib7 11113 6 number number NN cord-005453-4057qib7 11113 7 , , , cord-005453-4057qib7 11113 8 ex ex NN cord-005453-4057qib7 11113 9 vivo vivo NN cord-005453-4057qib7 11113 10 graft graft NN cord-005453-4057qib7 11113 11 - - HYPH cord-005453-4057qib7 11113 12 purging purging NN cord-005453-4057qib7 11113 13 method method NN cord-005453-4057qib7 11113 14 was be VBD cord-005453-4057qib7 11113 15 feasible feasible JJ cord-005453-4057qib7 11113 16 and and CC cord-005453-4057qib7 11113 17 safe safe JJ cord-005453-4057qib7 11113 18 in in IN cord-005453-4057qib7 11113 19 T t NN cord-005453-4057qib7 11113 20 - - HYPH cord-005453-4057qib7 11113 21 cell cell NN cord-005453-4057qib7 11113 22 lymphomas lymphoma NNS cord-005453-4057qib7 11113 23 . . . cord-005453-4057qib7 11114 1 And and CC cord-005453-4057qib7 11114 2 this this DT cord-005453-4057qib7 11114 3 purging purge VBG cord-005453-4057qib7 11114 4 strategy strategy NN cord-005453-4057qib7 11114 5 observed observe VBD cord-005453-4057qib7 11114 6 the the DT cord-005453-4057qib7 11114 7 more more RBR cord-005453-4057qib7 11114 8 favorable favorable JJ cord-005453-4057qib7 11114 9 survival survival NN cord-005453-4057qib7 11114 10 outcomes outcome NNS cord-005453-4057qib7 11114 11 in in IN cord-005453-4057qib7 11114 12 the the DT cord-005453-4057qib7 11114 13 upfront upfront JJ cord-005453-4057qib7 11114 14 auto auto NN cord-005453-4057qib7 11114 15 - - HYPH cord-005453-4057qib7 11114 16 HSCT HSCT NNP cord-005453-4057qib7 11114 17 than than IN cord-005453-4057qib7 11114 18 salvage salvage NN cord-005453-4057qib7 11114 19 setting setting NN cord-005453-4057qib7 11114 20 . . . cord-005453-4057qib7 11115 1 Therefore therefore RB cord-005453-4057qib7 11115 2 , , , cord-005453-4057qib7 11115 3 further further JJ cord-005453-4057qib7 11115 4 randomized randomized JJ cord-005453-4057qib7 11115 5 studies study NNS cord-005453-4057qib7 11115 6 are be VBP cord-005453-4057qib7 11115 7 needed need VBN cord-005453-4057qib7 11115 8 to to TO cord-005453-4057qib7 11115 9 determine determine VB cord-005453-4057qib7 11115 10 the the DT cord-005453-4057qib7 11115 11 firm firm JJ cord-005453-4057qib7 11115 12 efficacy efficacy NN cord-005453-4057qib7 11115 13 of of IN cord-005453-4057qib7 11115 14 CD34 CD34 NNP cord-005453-4057qib7 11115 15 + + CC cord-005453-4057qib7 11115 16 purification purification NN cord-005453-4057qib7 11115 17 with with IN cord-005453-4057qib7 11115 18 the the DT cord-005453-4057qib7 11115 19 large large JJ cord-005453-4057qib7 11115 20 number number NN cord-005453-4057qib7 11115 21 of of IN cord-005453-4057qib7 11115 22 patients patient NNS cord-005453-4057qib7 11115 23 in in IN cord-005453-4057qib7 11115 24 auto auto NN cord-005453-4057qib7 11115 25 - - HYPH cord-005453-4057qib7 11115 26 HSCT HSCT NNP cord-005453-4057qib7 11115 27 for for IN cord-005453-4057qib7 11115 28 T T NNP cord-005453-4057qib7 11115 29 cell cell NN cord-005453-4057qib7 11115 30 - - HYPH cord-005453-4057qib7 11115 31 lymphomas lymphoma NNS cord-005453-4057qib7 11115 32 . . . cord-005453-4057qib7 11116 1 Disclosure disclosure NN cord-005453-4057qib7 11116 2 : : : cord-005453-4057qib7 11116 3 Nothing nothing NN cord-005453-4057qib7 11116 4 to to TO cord-005453-4057qib7 11116 5 declare declare VB cord-005453-4057qib7 11116 6 Nivolumab Nivolumab NNP cord-005453-4057qib7 11116 7 - - HYPH cord-005453-4057qib7 11116 8 based base VBN cord-005453-4057qib7 11116 9 regimens regimen NNS cord-005453-4057qib7 11116 10 in in IN cord-005453-4057qib7 11116 11 relapsed relapsed JJ cord-005453-4057qib7 11116 12 or or CC cord-005453-4057qib7 11116 13 refractory refractory JJ cord-005453-4057qib7 11116 14 non non AFX cord-005453-4057qib7 11116 15 hodgkin hodgkin NNP cord-005453-4057qib7 11116 16 lymphomas lymphoma NNS cord-005453-4057qib7 11116 17 : : : cord-005453-4057qib7 11116 18 The the DT cord-005453-4057qib7 11116 19 role role NN cord-005453-4057qib7 11116 20 of of IN cord-005453-4057qib7 11116 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 11116 22 stem stem NN cord-005453-4057qib7 11116 23 cells cell NNS cord-005453-4057qib7 11116 24 transplantation transplantation NN cord-005453-4057qib7 11116 25 Methods method NNS cord-005453-4057qib7 11117 1 : : : cord-005453-4057qib7 11117 2 We -PRON- PRP cord-005453-4057qib7 11117 3 analyzed analyze VBD cord-005453-4057qib7 11117 4 data datum NNS cord-005453-4057qib7 11117 5 of of IN cord-005453-4057qib7 11117 6 18 18 CD cord-005453-4057qib7 11117 7 patients patient NNS cord-005453-4057qib7 11117 8 with with IN cord-005453-4057qib7 11117 9 r r NN cord-005453-4057qib7 11117 10 / / SYM cord-005453-4057qib7 11117 11 r r NN cord-005453-4057qib7 11117 12 NHL NHL NNP cord-005453-4057qib7 11117 13 , , , cord-005453-4057qib7 11117 14 among among IN cord-005453-4057qib7 11117 15 them -PRON- PRP cord-005453-4057qib7 11117 16 n11 n11 NN cord-005453-4057qib7 11117 17 with with IN cord-005453-4057qib7 11117 18 Diffuse diffuse JJ cord-005453-4057qib7 11117 19 large large JJ cord-005453-4057qib7 11117 20 B b NN cord-005453-4057qib7 11117 21 - - HYPH cord-005453-4057qib7 11117 22 cell cell NN cord-005453-4057qib7 11117 23 lymphoma lymphoma NN cord-005453-4057qib7 11117 24 ( ( -LRB- cord-005453-4057qib7 11117 25 DLBCL DLBCL NNP cord-005453-4057qib7 11117 26 ) ) -RRB- cord-005453-4057qib7 11117 27 , , , cord-005453-4057qib7 11117 28 n5 n5 NNP cord-005453-4057qib7 11117 29 with with IN cord-005453-4057qib7 11117 30 Primary primary JJ cord-005453-4057qib7 11117 31 mediastinal mediastinal JJ cord-005453-4057qib7 11117 32 B b NN cord-005453-4057qib7 11117 33 - - HYPH cord-005453-4057qib7 11117 34 cell cell NN cord-005453-4057qib7 11117 35 lymphoma lymphoma NN cord-005453-4057qib7 11117 36 ( ( -LRB- cord-005453-4057qib7 11117 37 PMBCL PMBCL NNP cord-005453-4057qib7 11117 38 ) ) -RRB- cord-005453-4057qib7 11117 39 , , , cord-005453-4057qib7 11117 40 n1 n1 NNP cord-005453-4057qib7 11117 41 with with IN cord-005453-4057qib7 11117 42 Gray Gray NNP cord-005453-4057qib7 11117 43 zone zone NN cord-005453-4057qib7 11117 44 lymphoma lymphoma NN cord-005453-4057qib7 11117 45 ( ( -LRB- cord-005453-4057qib7 11117 46 GZL GZL NNP cord-005453-4057qib7 11117 47 ) ) -RRB- cord-005453-4057qib7 11117 48 and and CC cord-005453-4057qib7 11117 49 n1 n1 NNP cord-005453-4057qib7 11117 50 with with IN cord-005453-4057qib7 11117 51 Gamma Gamma NNP cord-005453-4057qib7 11117 52 - - HYPH cord-005453-4057qib7 11117 53 Delta Delta NNP cord-005453-4057qib7 11117 54 peripheral peripheral JJ cord-005453-4057qib7 11117 55 T t NN cord-005453-4057qib7 11117 56 - - HYPH cord-005453-4057qib7 11117 57 cell cell NN cord-005453-4057qib7 11117 58 lymphoma lymphoma NN cord-005453-4057qib7 11117 59 ( ( -LRB- cord-005453-4057qib7 11117 60 PTCL PTCL NNP cord-005453-4057qib7 11117 61 ) ) -RRB- cord-005453-4057qib7 11117 62 , , , cord-005453-4057qib7 11117 63 who who WP cord-005453-4057qib7 11117 64 received receive VBD cord-005453-4057qib7 11117 65 nivolumab nivolumab NNP cord-005453-4057qib7 11117 66 - - HYPH cord-005453-4057qib7 11117 67 based base VBN cord-005453-4057qib7 11117 68 regimens regimen NNS cord-005453-4057qib7 11117 69 . . . cord-005453-4057qib7 11118 1 The the DT cord-005453-4057qib7 11118 2 median median JJ cord-005453-4057qib7 11118 3 age age NN cord-005453-4057qib7 11118 4 was be VBD cord-005453-4057qib7 11118 5 37 37 CD cord-005453-4057qib7 11118 6 years year NNS cord-005453-4057qib7 11118 7 ( ( -LRB- cord-005453-4057qib7 11118 8 range range NN cord-005453-4057qib7 11118 9 , , , cord-005453-4057qib7 11118 10 18 18 CD cord-005453-4057qib7 11118 11 -64 -64 NN cord-005453-4057qib7 11118 12 years year NNS cord-005453-4057qib7 11118 13 ) ) -RRB- cord-005453-4057qib7 11118 14 . . . cord-005453-4057qib7 11119 1 Most Most JJS cord-005453-4057qib7 11119 2 of of IN cord-005453-4057qib7 11119 3 the the DT cord-005453-4057qib7 11119 4 patients patient NNS cord-005453-4057qib7 11119 5 n14 n14 NNP cord-005453-4057qib7 11119 6 ( ( -LRB- cord-005453-4057qib7 11119 7 78 78 CD cord-005453-4057qib7 11119 8 % % NN cord-005453-4057qib7 11119 9 ) ) -RRB- cord-005453-4057qib7 11119 10 had have VBD cord-005453-4057qib7 11119 11 a a DT cord-005453-4057qib7 11119 12 primary primary JJ cord-005453-4057qib7 11119 13 chemoresistant chemoresistant JJ cord-005453-4057qib7 11119 14 disease disease NN cord-005453-4057qib7 11119 15 , , . cord-005453-4057qib7 11120 1 the the DT cord-005453-4057qib7 11120 2 rest rest NN cord-005453-4057qib7 11120 3 patients patient NNS cord-005453-4057qib7 11120 4 n4 n4 NNP cord-005453-4057qib7 11120 5 ( ( -LRB- cord-005453-4057qib7 11120 6 22 22 CD cord-005453-4057qib7 11120 7 % % NN cord-005453-4057qib7 11120 8 ) ) -RRB- cord-005453-4057qib7 11120 9 had have VBD cord-005453-4057qib7 11120 10 a a DT cord-005453-4057qib7 11120 11 relapse relapse NN cord-005453-4057qib7 11120 12 . . . cord-005453-4057qib7 11121 1 The the DT cord-005453-4057qib7 11121 2 median median NN cord-005453-4057qib7 11121 3 of of IN cord-005453-4057qib7 11121 4 lines line NNS cord-005453-4057qib7 11121 5 of of IN cord-005453-4057qib7 11121 6 prior prior JJ cord-005453-4057qib7 11121 7 therapy therapy NN cord-005453-4057qib7 11121 8 was be VBD cord-005453-4057qib7 11121 9 3 3 CD cord-005453-4057qib7 11121 10 lines line NNS cord-005453-4057qib7 11121 11 ( ( -LRB- cord-005453-4057qib7 11121 12 range range NN cord-005453-4057qib7 11121 13 , , , cord-005453-4057qib7 11121 14 2 2 CD cord-005453-4057qib7 11121 15 - - SYM cord-005453-4057qib7 11121 16 6 6 CD cord-005453-4057qib7 11121 17 lines line NNS cord-005453-4057qib7 11121 18 ) ) -RRB- cord-005453-4057qib7 11121 19 . . . cord-005453-4057qib7 11122 1 All all DT cord-005453-4057qib7 11122 2 sixteen sixteen CD cord-005453-4057qib7 11122 3 patients patient NNS cord-005453-4057qib7 11122 4 with with IN cord-005453-4057qib7 11122 5 DLBCL DLBCL NNP cord-005453-4057qib7 11122 6 and and CC cord-005453-4057qib7 11122 7 PMBCL PMBCL NNP cord-005453-4057qib7 11122 8 received receive VBD cord-005453-4057qib7 11122 9 1 1 CD cord-005453-4057qib7 11122 10 -3 -3 NNP cord-005453-4057qib7 11122 11 cycles cycle NNS cord-005453-4057qib7 11122 12 of of IN cord-005453-4057qib7 11122 13 nivolumab nivolumab NNP cord-005453-4057qib7 11122 14 in in IN cord-005453-4057qib7 11122 15 combination combination NN cord-005453-4057qib7 11122 16 with with IN cord-005453-4057qib7 11122 17 bendamustine bendamustine NNP cord-005453-4057qib7 11122 18 , , , cord-005453-4057qib7 11122 19 gemcitabine gemcitabine NNP cord-005453-4057qib7 11122 20 and and CC cord-005453-4057qib7 11122 21 rituximab rituximab NN cord-005453-4057qib7 11122 22 ( ( -LRB- cord-005453-4057qib7 11122 23 BeGeRN BeGeRN NNP cord-005453-4057qib7 11122 24 ) ) -RRB- cord-005453-4057qib7 11122 25 . . . cord-005453-4057qib7 11123 1 The the DT cord-005453-4057qib7 11123 2 patient patient NN cord-005453-4057qib7 11123 3 with with IN cord-005453-4057qib7 11123 4 GZL GZL NNP cord-005453-4057qib7 11123 5 received receive VBD cord-005453-4057qib7 11123 6 5 5 CD cord-005453-4057qib7 11123 7 cycles cycle NNS cord-005453-4057qib7 11123 8 of of IN cord-005453-4057qib7 11123 9 nivolumab nivolumab NNP cord-005453-4057qib7 11123 10 in in IN cord-005453-4057qib7 11123 11 combination combination NN cord-005453-4057qib7 11123 12 with with IN cord-005453-4057qib7 11123 13 brentuximab brentuximab NNP cord-005453-4057qib7 11123 14 vedotin vedotin NNP cord-005453-4057qib7 11123 15 and and CC cord-005453-4057qib7 11123 16 EPOCH epoch NN cord-005453-4057qib7 11123 17 . . . cord-005453-4057qib7 11124 1 And and CC cord-005453-4057qib7 11124 2 the the DT cord-005453-4057qib7 11124 3 patient patient NN cord-005453-4057qib7 11124 4 with with IN cord-005453-4057qib7 11124 5 PTCL PTCL NNP cord-005453-4057qib7 11124 6 received receive VBD cord-005453-4057qib7 11124 7 10 10 CD cord-005453-4057qib7 11124 8 cycles cycle NNS cord-005453-4057qib7 11124 9 of of IN cord-005453-4057qib7 11124 10 nivolumab nivolumab NNP cord-005453-4057qib7 11124 11 monotherapy monotherapy NN cord-005453-4057qib7 11124 12 . . . cord-005453-4057qib7 11125 1 Results result NNS cord-005453-4057qib7 11125 2 : : : cord-005453-4057qib7 11126 1 At at IN cord-005453-4057qib7 11126 2 median median NN cord-005453-4057qib7 11126 3 follow follow VB cord-005453-4057qib7 11126 4 up up RB cord-005453-4057qib7 11126 5 8 8 CD cord-005453-4057qib7 11126 6 months month NNS cord-005453-4057qib7 11126 7 ( ( -LRB- cord-005453-4057qib7 11126 8 3 3 CD cord-005453-4057qib7 11126 9 - - SYM cord-005453-4057qib7 11126 10 16 16 CD cord-005453-4057qib7 11126 11 ) ) -RRB- cord-005453-4057qib7 11126 12 objective objective JJ cord-005453-4057qib7 11126 13 response response NN cord-005453-4057qib7 11126 14 ( ( -LRB- cord-005453-4057qib7 11126 15 OR OR NNP cord-005453-4057qib7 11126 16 ) ) -RRB- cord-005453-4057qib7 11126 17 after after IN cord-005453-4057qib7 11126 18 nivolumab nivolumab NNP cord-005453-4057qib7 11126 19 - - HYPH cord-005453-4057qib7 11126 20 based base VBN cord-005453-4057qib7 11126 21 regimens regimen NNS cord-005453-4057qib7 11126 22 was be VBD cord-005453-4057qib7 11126 23 noted note VBN cord-005453-4057qib7 11126 24 in in IN cord-005453-4057qib7 11126 25 n10 n10 NN cord-005453-4057qib7 11126 26 ( ( -LRB- cord-005453-4057qib7 11126 27 56 56 CD cord-005453-4057qib7 11126 28 % % NN cord-005453-4057qib7 11126 29 ) ) -RRB- cord-005453-4057qib7 11126 30 patients patient NNS cord-005453-4057qib7 11126 31 , , , cord-005453-4057qib7 11126 32 complete complete JJ cord-005453-4057qib7 11126 33 response response NN cord-005453-4057qib7 11126 34 ( ( -LRB- cord-005453-4057qib7 11126 35 CR CR NNP cord-005453-4057qib7 11126 36 ) ) -RRB- cord-005453-4057qib7 11126 37 and and CC cord-005453-4057qib7 11126 38 partial partial JJ cord-005453-4057qib7 11126 39 response response NN cord-005453-4057qib7 11126 40 ( ( -LRB- cord-005453-4057qib7 11126 41 PR PR NNP cord-005453-4057qib7 11126 42 ) ) -RRB- cord-005453-4057qib7 11126 43 in in IN cord-005453-4057qib7 11126 44 n9 n9 NNP cord-005453-4057qib7 11126 45 ( ( -LRB- cord-005453-4057qib7 11126 46 50 50 CD cord-005453-4057qib7 11126 47 % % NN cord-005453-4057qib7 11126 48 ) ) -RRB- cord-005453-4057qib7 11126 49 and and CC cord-005453-4057qib7 11126 50 n1 n1 NNP cord-005453-4057qib7 11126 51 ( ( -LRB- cord-005453-4057qib7 11126 52 6 6 CD cord-005453-4057qib7 11126 53 % % NN cord-005453-4057qib7 11126 54 ) ) -RRB- cord-005453-4057qib7 11126 55 patients patient NNS cord-005453-4057qib7 11126 56 , , , cord-005453-4057qib7 11126 57 respectively respectively RB cord-005453-4057qib7 11126 58 . . . cord-005453-4057qib7 11127 1 CR CR NNP cord-005453-4057qib7 11127 2 observed observe VBD cord-005453-4057qib7 11127 3 in in IN cord-005453-4057qib7 11127 4 n4 n4 CD cord-005453-4057qib7 11127 5 patients patient NNS cord-005453-4057qib7 11127 6 with with IN cord-005453-4057qib7 11127 7 DLBCL DLBCL NNP cord-005453-4057qib7 11127 8 , , , cord-005453-4057qib7 11127 9 n3 n3 NN cord-005453-4057qib7 11127 10 with with IN cord-005453-4057qib7 11127 11 PMBCL PMBCL NNP cord-005453-4057qib7 11127 12 , , , cord-005453-4057qib7 11127 13 n1 n1 NNP cord-005453-4057qib7 11127 14 with with IN cord-005453-4057qib7 11127 15 GZL GZL NNP cord-005453-4057qib7 11127 16 , , , cord-005453-4057qib7 11127 17 n1 n1 NNP cord-005453-4057qib7 11127 18 with with IN cord-005453-4057qib7 11127 19 PTCL PTCL NNP cord-005453-4057qib7 11127 20 . . . cord-005453-4057qib7 11128 1 And and CC cord-005453-4057qib7 11128 2 PR PR NNP cord-005453-4057qib7 11128 3 observed observe VBD cord-005453-4057qib7 11128 4 in in IN cord-005453-4057qib7 11128 5 1 1 CD cord-005453-4057qib7 11128 6 patient patient NN cord-005453-4057qib7 11128 7 with with IN cord-005453-4057qib7 11128 8 DLBCL DLBCL NNP cord-005453-4057qib7 11128 9 . . . cord-005453-4057qib7 11129 1 Two two CD cord-005453-4057qib7 11129 2 responding respond VBG cord-005453-4057qib7 11129 3 patients patient NNS cord-005453-4057qib7 11129 4 with with IN cord-005453-4057qib7 11129 5 DLBCL DLBCL NNP cord-005453-4057qib7 11129 6 underwent undergo VBN cord-005453-4057qib7 11129 7 auto auto NN cord-005453-4057qib7 11129 8 - - HYPH cord-005453-4057qib7 11129 9 HSCT HSCT NNP cord-005453-4057qib7 11129 10 . . . cord-005453-4057qib7 11130 1 And and CC cord-005453-4057qib7 11130 2 four four CD cord-005453-4057qib7 11130 3 responding respond VBG cord-005453-4057qib7 11130 4 patients patient NNS cord-005453-4057qib7 11130 5 ( ( -LRB- cord-005453-4057qib7 11130 6 n1 n1 NNP cord-005453-4057qib7 11130 7 DLBCL DLBCL NNP cord-005453-4057qib7 11130 8 , , , cord-005453-4057qib7 11130 9 n1 n1 NNP cord-005453-4057qib7 11130 10 PMBCL PMBCL NNP cord-005453-4057qib7 11130 11 , , , cord-005453-4057qib7 11130 12 n1 n1 NNP cord-005453-4057qib7 11130 13 GZL GZL NNP cord-005453-4057qib7 11130 14 , , , cord-005453-4057qib7 11130 15 n1 n1 NNP cord-005453-4057qib7 11130 16 PTCL PTCL NNP cord-005453-4057qib7 11130 17 ) ) -RRB- cord-005453-4057qib7 11130 18 received receive VBD cord-005453-4057qib7 11130 19 allogeneic allogeneic JJ cord-005453-4057qib7 11130 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 11130 21 stem stem NN cord-005453-4057qib7 11130 22 cells cell NNS cord-005453-4057qib7 11130 23 transplantation transplantation NN cord-005453-4057qib7 11130 24 ( ( -LRB- cord-005453-4057qib7 11130 25 allo allo NN cord-005453-4057qib7 11130 26 - - HYPH cord-005453-4057qib7 11130 27 HSCT HSCT NNP cord-005453-4057qib7 11130 28 ) ) -RRB- cord-005453-4057qib7 11130 29 . . . cord-005453-4057qib7 11131 1 The the DT cord-005453-4057qib7 11131 2 median median JJ cord-005453-4057qib7 11131 3 duration duration NN cord-005453-4057qib7 11131 4 of of IN cord-005453-4057qib7 11131 5 response response NN cord-005453-4057qib7 11131 6 for for IN cord-005453-4057qib7 11131 7 all all DT cord-005453-4057qib7 11131 8 n10 n10 CD cord-005453-4057qib7 11131 9 patients patient NNS cord-005453-4057qib7 11131 10 with with IN cord-005453-4057qib7 11131 11 OR or CC cord-005453-4057qib7 11131 12 was be VBD cord-005453-4057qib7 11131 13 5 5 CD cord-005453-4057qib7 11132 1 ( ( -LRB- cord-005453-4057qib7 11132 2 range range NN cord-005453-4057qib7 11132 3 : : : cord-005453-4057qib7 11132 4 3 3 CD cord-005453-4057qib7 11132 5 - - SYM cord-005453-4057qib7 11132 6 16 16 CD cord-005453-4057qib7 11132 7 + + SYM cord-005453-4057qib7 11132 8 ) ) -RRB- cord-005453-4057qib7 11132 9 months month NNS cord-005453-4057qib7 11132 10 . . . cord-005453-4057qib7 11133 1 Among among IN cord-005453-4057qib7 11133 2 n4 n4 NN cord-005453-4057qib7 11133 3 patients patient NNS cord-005453-4057qib7 11133 4 who who WP cord-005453-4057qib7 11133 5 achieved achieve VBD cord-005453-4057qib7 11133 6 OR or CC cord-005453-4057qib7 11133 7 without without IN cord-005453-4057qib7 11133 8 HSCT HSCT NNP cord-005453-4057qib7 11133 9 , , , cord-005453-4057qib7 11133 10 only only RB cord-005453-4057qib7 11133 11 n1 n1 NNP cord-005453-4057qib7 11133 12 remain remain VBP cord-005453-4057qib7 11133 13 in in IN cord-005453-4057qib7 11133 14 CR CR NNP cord-005453-4057qib7 11133 15 . . . cord-005453-4057qib7 11134 1 Two two CD cord-005453-4057qib7 11134 2 patients patient NNS cord-005453-4057qib7 11134 3 who who WP cord-005453-4057qib7 11134 4 received receive VBD cord-005453-4057qib7 11134 5 auto auto NN cord-005453-4057qib7 11134 6 - - HYPH cord-005453-4057qib7 11134 7 HSCT HSCT NNP cord-005453-4057qib7 11134 8 had have VBD cord-005453-4057qib7 11134 9 a a DT cord-005453-4057qib7 11134 10 relapse relapse NN cord-005453-4057qib7 11134 11 . . . cord-005453-4057qib7 11135 1 One one CD cord-005453-4057qib7 11135 2 patient patient NN cord-005453-4057qib7 11135 3 with with IN cord-005453-4057qib7 11135 4 DLBCL DLBCL NNP cord-005453-4057qib7 11135 5 improved improve VBN cord-005453-4057qib7 11135 6 the the DT cord-005453-4057qib7 11135 7 response response NN cord-005453-4057qib7 11135 8 after after IN cord-005453-4057qib7 11135 9 allo allo NN cord-005453-4057qib7 11135 10 - - HYPH cord-005453-4057qib7 11135 11 HSCT HSCT NNP cord-005453-4057qib7 11135 12 from from IN cord-005453-4057qib7 11135 13 PR PR NNP cord-005453-4057qib7 11135 14 to to IN cord-005453-4057qib7 11135 15 CR CR NNP cord-005453-4057qib7 11135 16 , , , cord-005453-4057qib7 11135 17 and and CC cord-005453-4057qib7 11135 18 all all DT cord-005453-4057qib7 11135 19 four four CD cord-005453-4057qib7 11135 20 patients patient NNS cord-005453-4057qib7 11135 21 with with IN cord-005453-4057qib7 11135 22 allo allo NN cord-005453-4057qib7 11135 23 - - HYPH cord-005453-4057qib7 11135 24 HSCT HSCT NNP cord-005453-4057qib7 11135 25 remain remain VBP cord-005453-4057qib7 11135 26 in in IN cord-005453-4057qib7 11135 27 CR CR NNP cord-005453-4057qib7 11135 28 . . . cord-005453-4057qib7 11136 1 The the DT cord-005453-4057qib7 11136 2 probabilities probability NNS cord-005453-4057qib7 11136 3 of of IN cord-005453-4057qib7 11136 4 1-year 1-year CD cord-005453-4057qib7 11136 5 OS OS NNP cord-005453-4057qib7 11136 6 and and CC cord-005453-4057qib7 11136 7 PFS PFS NNP cord-005453-4057qib7 11136 8 rates rate NNS cord-005453-4057qib7 11136 9 were be VBD cord-005453-4057qib7 11136 10 49 49 CD cord-005453-4057qib7 11136 11 % % NN cord-005453-4057qib7 11136 12 and and CC cord-005453-4057qib7 11136 13 31 31 CD cord-005453-4057qib7 11136 14 % % NN cord-005453-4057qib7 11136 15 , , , cord-005453-4057qib7 11136 16 respectively respectively RB cord-005453-4057qib7 11136 17 . . . cord-005453-4057qib7 11137 1 Conclusions conclusion NNS cord-005453-4057qib7 11137 2 : : : cord-005453-4057qib7 11138 1 Nivolumab Nivolumab NNP cord-005453-4057qib7 11138 2 - - HYPH cord-005453-4057qib7 11138 3 based base VBN cord-005453-4057qib7 11138 4 regimens regimen NNS cord-005453-4057qib7 11138 5 can can MD cord-005453-4057qib7 11138 6 lead lead VB cord-005453-4057qib7 11138 7 to to IN cord-005453-4057qib7 11138 8 an an DT cord-005453-4057qib7 11138 9 objective objective JJ cord-005453-4057qib7 11138 10 response response NN cord-005453-4057qib7 11138 11 in in IN cord-005453-4057qib7 11138 12 56 56 CD cord-005453-4057qib7 11138 13 % % NN cord-005453-4057qib7 11138 14 patients patient NNS cord-005453-4057qib7 11138 15 with with IN cord-005453-4057qib7 11138 16 r r NN cord-005453-4057qib7 11138 17 / / SYM cord-005453-4057qib7 11138 18 r r NN cord-005453-4057qib7 11138 19 NHL NHL NNP cord-005453-4057qib7 11138 20 . . . cord-005453-4057qib7 11139 1 However however RB cord-005453-4057qib7 11139 2 , , , cord-005453-4057qib7 11139 3 the the DT cord-005453-4057qib7 11139 4 durability durability NN cord-005453-4057qib7 11139 5 of of IN cord-005453-4057qib7 11139 6 response response NN cord-005453-4057qib7 11139 7 to to IN cord-005453-4057qib7 11139 8 therapy therapy NN cord-005453-4057qib7 11139 9 is be VBZ cord-005453-4057qib7 11139 10 not not RB cord-005453-4057qib7 11139 11 long long JJ cord-005453-4057qib7 11139 12 . . . cord-005453-4057qib7 11140 1 Nivolumab Nivolumab NNP cord-005453-4057qib7 11140 2 - - HYPH cord-005453-4057qib7 11140 3 based base VBN cord-005453-4057qib7 11140 4 regimens regimen NNS cord-005453-4057qib7 11140 5 can can MD cord-005453-4057qib7 11140 6 be be VB cord-005453-4057qib7 11140 7 used use VBN cord-005453-4057qib7 11140 8 as as IN cord-005453-4057qib7 11140 9 bridge bridge NN cord-005453-4057qib7 11140 10 to to IN cord-005453-4057qib7 11140 11 allo allo NN cord-005453-4057qib7 11140 12 - - HYPH cord-005453-4057qib7 11140 13 HSCT HSCT NNP cord-005453-4057qib7 11140 14 Disclosure Disclosure NNP cord-005453-4057qib7 11140 15 : : : cord-005453-4057qib7 11140 16 There there EX cord-005453-4057qib7 11140 17 are be VBP cord-005453-4057qib7 11140 18 no no DT cord-005453-4057qib7 11140 19 conflicts conflict NNS cord-005453-4057qib7 11140 20 of of IN cord-005453-4057qib7 11140 21 interest interest NN cord-005453-4057qib7 11140 22 to to TO cord-005453-4057qib7 11140 23 disclose disclose VB cord-005453-4057qib7 11140 24 Background background NN cord-005453-4057qib7 11140 25 : : : cord-005453-4057qib7 11140 26 Patients patient NNS cord-005453-4057qib7 11140 27 with with IN cord-005453-4057qib7 11140 28 aggressive aggressive JJ cord-005453-4057qib7 11140 29 non non JJ cord-005453-4057qib7 11140 30 - - JJ cord-005453-4057qib7 11140 31 Hodgkin hodgkin JJ cord-005453-4057qib7 11140 32 lymphoma lymphoma NN cord-005453-4057qib7 11140 33 ( ( -LRB- cord-005453-4057qib7 11140 34 NHL NHL NNP cord-005453-4057qib7 11140 35 ) ) -RRB- cord-005453-4057qib7 11140 36 who who WP cord-005453-4057qib7 11140 37 relapse relapse VBP cord-005453-4057qib7 11140 38 after after IN cord-005453-4057qib7 11140 39 autologous autologous JJ cord-005453-4057qib7 11140 40 stem stem NN cord-005453-4057qib7 11140 41 cell cell NN cord-005453-4057qib7 11140 42 transplantation transplantation NN cord-005453-4057qib7 11140 43 have have VBP cord-005453-4057qib7 11140 44 a a DT cord-005453-4057qib7 11140 45 dismal dismal JJ cord-005453-4057qib7 11140 46 outcome outcome NN cord-005453-4057qib7 11140 47 and and CC cord-005453-4057qib7 11140 48 could could MD cord-005453-4057qib7 11140 49 benefit benefit VB cord-005453-4057qib7 11140 50 from from IN cord-005453-4057qib7 11140 51 radiotherapy radiotherapy NN cord-005453-4057qib7 11140 52 , , , cord-005453-4057qib7 11140 53 allogeneic allogeneic NN cord-005453-4057qib7 11140 54 stem stem NN cord-005453-4057qib7 11140 55 cell cell NN cord-005453-4057qib7 11140 56 transplantation transplantation NN cord-005453-4057qib7 11140 57 or or CC cord-005453-4057qib7 11140 58 experimental experimental JJ cord-005453-4057qib7 11140 59 treatments treatment NNS cord-005453-4057qib7 11140 60 . . . cord-005453-4057qib7 11141 1 Systemic systemic JJ cord-005453-4057qib7 11141 2 inflammatory inflammatory JJ cord-005453-4057qib7 11141 3 parameters parameter NNS cord-005453-4057qib7 11141 4 at at IN cord-005453-4057qib7 11141 5 diagnosis diagnosis NN cord-005453-4057qib7 11141 6 have have VBP cord-005453-4057qib7 11141 7 demonstrated demonstrate VBN cord-005453-4057qib7 11141 8 to to TO cord-005453-4057qib7 11141 9 be be VB cord-005453-4057qib7 11141 10 useful useful JJ cord-005453-4057qib7 11141 11 to to TO cord-005453-4057qib7 11141 12 predict predict VB cord-005453-4057qib7 11141 13 lymphoma lymphoma NN cord-005453-4057qib7 11141 14 evolution evolution NN cord-005453-4057qib7 11141 15 . . . cord-005453-4057qib7 11142 1 Methods method NNS cord-005453-4057qib7 11142 2 : : : cord-005453-4057qib7 11142 3 We -PRON- PRP cord-005453-4057qib7 11142 4 conducted conduct VBD cord-005453-4057qib7 11142 5 a a DT cord-005453-4057qib7 11142 6 retrospective retrospective JJ cord-005453-4057qib7 11142 7 review review NN cord-005453-4057qib7 11142 8 of of IN cord-005453-4057qib7 11142 9 patients patient NNS cord-005453-4057qib7 11142 10 with with IN cord-005453-4057qib7 11142 11 aggressive aggressive JJ cord-005453-4057qib7 11142 12 NHL NHL NNP cord-005453-4057qib7 11142 13 who who WP cord-005453-4057qib7 11142 14 underwent undergo VBD cord-005453-4057qib7 11142 15 autologous autologous JJ cord-005453-4057qib7 11142 16 stem stem NN cord-005453-4057qib7 11142 17 cell cell NN cord-005453-4057qib7 11142 18 transplantation transplantation NN cord-005453-4057qib7 11142 19 ( ( -LRB- cord-005453-4057qib7 11142 20 ASTC ASTC NNP cord-005453-4057qib7 11142 21 ) ) -RRB- cord-005453-4057qib7 11142 22 to to TO cord-005453-4057qib7 11142 23 evaluate evaluate VB cord-005453-4057qib7 11142 24 the the DT cord-005453-4057qib7 11142 25 relationship relationship NN cord-005453-4057qib7 11142 26 between between IN cord-005453-4057qib7 11142 27 LDH LDH NNP cord-005453-4057qib7 11142 28 , , , cord-005453-4057qib7 11142 29 β2-microglobulin β2-microglobulin XX cord-005453-4057qib7 11142 30 , , , cord-005453-4057qib7 11142 31 inflammatory inflammatory JJ cord-005453-4057qib7 11142 32 parameters parameter NNS cord-005453-4057qib7 11142 33 ( ( -LRB- cord-005453-4057qib7 11142 34 lymphocyte lymphocyte NN cord-005453-4057qib7 11142 35 ( ( -LRB- cord-005453-4057qib7 11142 36 ALC ALC NNP cord-005453-4057qib7 11142 37 ) ) -RRB- cord-005453-4057qib7 11142 38 and and CC cord-005453-4057qib7 11142 39 monocyte monocyte NNP cord-005453-4057qib7 11142 40 count count NNP cord-005453-4057qib7 11142 41 ( ( -LRB- cord-005453-4057qib7 11142 42 AMC AMC NNP cord-005453-4057qib7 11142 43 ) ) -RRB- cord-005453-4057qib7 11142 44 , , , cord-005453-4057qib7 11142 45 ferritin ferritin NN cord-005453-4057qib7 11142 46 or or CC cord-005453-4057qib7 11142 47 C c NN cord-005453-4057qib7 11142 48 - - HYPH cord-005453-4057qib7 11142 49 reactive reactive JJ cord-005453-4057qib7 11142 50 protein protein NN cord-005453-4057qib7 11142 51 ) ) -RRB- cord-005453-4057qib7 11142 52 and and CC cord-005453-4057qib7 11142 53 imaging image VBG cord-005453-4057qib7 11142 54 techniques technique NNS cord-005453-4057qib7 11142 55 before before IN cord-005453-4057qib7 11142 56 and and CC cord-005453-4057qib7 11142 57 on on IN cord-005453-4057qib7 11142 58 day day NN cord-005453-4057qib7 11142 59 +100 +100 HYPH cord-005453-4057qib7 11142 60 post post NN cord-005453-4057qib7 11142 61 - - JJ cord-005453-4057qib7 11142 62 ASTC ASTC NNP cord-005453-4057qib7 11142 63 and and CC cord-005453-4057qib7 11142 64 progression progression NN cord-005453-4057qib7 11142 65 free free JJ cord-005453-4057qib7 11142 66 survival survival NN cord-005453-4057qib7 11142 67 ( ( -LRB- cord-005453-4057qib7 11142 68 PFS PFS NNP cord-005453-4057qib7 11142 69 ) ) -RRB- cord-005453-4057qib7 11142 70 , , , cord-005453-4057qib7 11142 71 as as RB cord-005453-4057qib7 11142 72 well well RB cord-005453-4057qib7 11142 73 as as IN cord-005453-4057qib7 11142 74 the the DT cord-005453-4057qib7 11142 75 role role NN cord-005453-4057qib7 11142 76 of of IN cord-005453-4057qib7 11142 77 residual residual JJ cord-005453-4057qib7 11142 78 disease disease NN cord-005453-4057qib7 11142 79 directed direct VBD cord-005453-4057qib7 11142 80 radiotherapy radiotherapy NNP cord-005453-4057qib7 11142 81 ( ( -LRB- cord-005453-4057qib7 11142 82 RT RT NNP cord-005453-4057qib7 11142 83 ) ) -RRB- cord-005453-4057qib7 11142 84 . . . cord-005453-4057qib7 11143 1 Results result NNS cord-005453-4057qib7 11143 2 : : : cord-005453-4057qib7 11144 1 One one CD cord-005453-4057qib7 11144 2 hundred hundred CD cord-005453-4057qib7 11144 3 and and CC cord-005453-4057qib7 11144 4 sixty sixty CD cord-005453-4057qib7 11144 5 patients patient NNS cord-005453-4057qib7 11144 6 with with IN cord-005453-4057qib7 11144 7 aggressive aggressive JJ cord-005453-4057qib7 11144 8 NHL NHL NNP cord-005453-4057qib7 11144 9 received receive VBD cord-005453-4057qib7 11144 10 ASCT ASCT NNP cord-005453-4057qib7 11144 11 as as IN cord-005453-4057qib7 11144 12 consolidation consolidation NN cord-005453-4057qib7 11144 13 treatment treatment NN cord-005453-4057qib7 11144 14 in in IN cord-005453-4057qib7 11144 15 our -PRON- PRP$ cord-005453-4057qib7 11144 16 center center NN cord-005453-4057qib7 11144 17 between between IN cord-005453-4057qib7 11144 18 2000 2000 CD cord-005453-4057qib7 11144 19 and and CC cord-005453-4057qib7 11144 20 2017 2017 CD cord-005453-4057qib7 11144 21 . . . cord-005453-4057qib7 11145 1 The the DT cord-005453-4057qib7 11145 2 most most RBS cord-005453-4057qib7 11145 3 common common JJ cord-005453-4057qib7 11145 4 diagnosis diagnosis NN cord-005453-4057qib7 11145 5 was be VBD cord-005453-4057qib7 11145 6 diffuse diffuse JJ cord-005453-4057qib7 11145 7 large large JJ cord-005453-4057qib7 11145 8 B b NN cord-005453-4057qib7 11145 9 - - HYPH cord-005453-4057qib7 11145 10 cell cell NN cord-005453-4057qib7 11145 11 lymphoma lymphoma NN cord-005453-4057qib7 11145 12 ( ( -LRB- cord-005453-4057qib7 11145 13 DLBCL DLBCL NNP cord-005453-4057qib7 11145 14 ) ) -RRB- cord-005453-4057qib7 11145 15 . . . cord-005453-4057qib7 11146 1 One one CD cord-005453-4057qib7 11146 2 hundred hundred CD cord-005453-4057qib7 11146 3 and and CC cord-005453-4057qib7 11146 4 nine nine CD cord-005453-4057qib7 11146 5 patients patient NNS cord-005453-4057qib7 11146 6 received receive VBD cord-005453-4057qib7 11146 7 upfront upfront JJ cord-005453-4057qib7 11146 8 ASCT ASCT NNP cord-005453-4057qib7 11146 9 for for IN cord-005453-4057qib7 11146 10 high high JJ cord-005453-4057qib7 11146 11 risk risk NN cord-005453-4057qib7 11146 12 DLBCL DLBCL NNP cord-005453-4057qib7 11146 13 ( ( -LRB- cord-005453-4057qib7 11146 14 defined define VBN cord-005453-4057qib7 11146 15 as as IN cord-005453-4057qib7 11146 16 age age NN cord-005453-4057qib7 11146 17 - - HYPH cord-005453-4057qib7 11146 18 adjusted adjust VBN cord-005453-4057qib7 11146 19 IPI IPI NNP cord-005453-4057qib7 11146 20 2 2 CD cord-005453-4057qib7 11146 21 - - HYPH cord-005453-4057qib7 11146 22 3)(n=28 3)(n=28 CD cord-005453-4057qib7 11146 23 ) ) -RRB- cord-005453-4057qib7 11146 24 or or CC cord-005453-4057qib7 11146 25 for for IN cord-005453-4057qib7 11146 26 having have VBG cord-005453-4057qib7 11146 27 received receive VBN cord-005453-4057qib7 11146 28 two two CD cord-005453-4057qib7 11146 29 or or CC cord-005453-4057qib7 11146 30 more more JJR cord-005453-4057qib7 11146 31 lines line NNS cord-005453-4057qib7 11146 32 to to TO cord-005453-4057qib7 11146 33 obtain obtain VB cord-005453-4057qib7 11146 34 first first JJ cord-005453-4057qib7 11146 35 complete complete JJ cord-005453-4057qib7 11146 36 remission remission NN cord-005453-4057qib7 11146 37 ( ( -LRB- cord-005453-4057qib7 11146 38 n=28 n=28 RB cord-005453-4057qib7 11146 39 ) ) -RRB- cord-005453-4057qib7 11146 40 , , , cord-005453-4057qib7 11146 41 for for IN cord-005453-4057qib7 11146 42 T t NN cord-005453-4057qib7 11146 43 - - HYPH cord-005453-4057qib7 11146 44 cell cell NN cord-005453-4057qib7 11146 45 lymphoma lymphoma NN cord-005453-4057qib7 11146 46 ( ( -LRB- cord-005453-4057qib7 11146 47 n=27 n=27 NNP cord-005453-4057qib7 11146 48 ) ) -RRB- cord-005453-4057qib7 11146 49 and and CC cord-005453-4057qib7 11146 50 for for IN cord-005453-4057qib7 11146 51 mantle mantle NN cord-005453-4057qib7 11146 52 cell cell NN cord-005453-4057qib7 11146 53 lymphoma lymphoma NN cord-005453-4057qib7 11146 54 ( ( -LRB- cord-005453-4057qib7 11146 55 n=26 n=26 RB cord-005453-4057qib7 11146 56 ) ) -RRB- cord-005453-4057qib7 11146 57 . . . cord-005453-4057qib7 11147 1 The the DT cord-005453-4057qib7 11147 2 rest rest NN cord-005453-4057qib7 11147 3 was be VBD cord-005453-4057qib7 11147 4 performed perform VBN cord-005453-4057qib7 11147 5 in in IN cord-005453-4057qib7 11147 6 relapsed relapsed JJ cord-005453-4057qib7 11147 7 lymphomas lymphoma NNS cord-005453-4057qib7 11147 8 . . . cord-005453-4057qib7 11148 1 Forty forty CD cord-005453-4057qib7 11148 2 - - HYPH cord-005453-4057qib7 11148 3 seven seven CD cord-005453-4057qib7 11148 4 patients patient NNS cord-005453-4057qib7 11148 5 ( ( -LRB- cord-005453-4057qib7 11148 6 29 29 CD cord-005453-4057qib7 11148 7 % % NN cord-005453-4057qib7 11148 8 ) ) -RRB- cord-005453-4057qib7 11148 9 relapsed relapse VBN cord-005453-4057qib7 11148 10 and and CC cord-005453-4057qib7 11148 11 PFS PFS NNP cord-005453-4057qib7 11148 12 was be VBD cord-005453-4057qib7 11148 13 110 110 CD cord-005453-4057qib7 11148 14 months month NNS cord-005453-4057qib7 11148 15 . . . cord-005453-4057qib7 11149 1 Pretransplant pretransplant JJ cord-005453-4057qib7 11149 2 response response NN cord-005453-4057qib7 11149 3 was be VBD cord-005453-4057qib7 11149 4 evaluated evaluate VBN cord-005453-4057qib7 11149 5 with with IN cord-005453-4057qib7 11149 6 CT CT NNP cord-005453-4057qib7 11149 7 scan scan NN cord-005453-4057qib7 11149 8 in in IN cord-005453-4057qib7 11149 9 66 66 CD cord-005453-4057qib7 11149 10 patients patient NNS cord-005453-4057qib7 11149 11 ( ( -LRB- cord-005453-4057qib7 11149 12 11 11 CD cord-005453-4057qib7 11149 13 of of IN cord-005453-4057qib7 11149 14 this this DT cord-005453-4057qib7 11149 15 with with IN cord-005453-4057qib7 11149 16 partial partial JJ cord-005453-4057qib7 11149 17 remission remission NN cord-005453-4057qib7 11149 18 ( ( -LRB- cord-005453-4057qib7 11149 19 CT CT NNP cord-005453-4057qib7 11149 20 - - HYPH cord-005453-4057qib7 11149 21 PR PR NNP cord-005453-4057qib7 11149 22 ) ) -RRB- cord-005453-4057qib7 11149 23 and and CC cord-005453-4057qib7 11149 24 94 94 CD cord-005453-4057qib7 11149 25 patients patient NNS cord-005453-4057qib7 11149 26 were be VBD cord-005453-4057qib7 11149 27 evaluated evaluate VBN cord-005453-4057qib7 11149 28 with with IN cord-005453-4057qib7 11149 29 FDGPET FDGPET NNP cord-005453-4057qib7 11149 30 / / SYM cord-005453-4057qib7 11149 31 CT CT NNP cord-005453-4057qib7 11149 32 ( ( -LRB- cord-005453-4057qib7 11149 33 27 27 CD cord-005453-4057qib7 11149 34 were be VBD cord-005453-4057qib7 11150 1 pretransplant pretransplant JJ cord-005453-4057qib7 11150 2 positive positive JJ cord-005453-4057qib7 11150 3 ( ( -LRB- cord-005453-4057qib7 11150 4 PET1 PET1 NNP cord-005453-4057qib7 11150 5 ) ) -RRB- cord-005453-4057qib7 11150 6 ; ; : cord-005453-4057qib7 11150 7 of of IN cord-005453-4057qib7 11150 8 these these DT cord-005453-4057qib7 11150 9 , , , cord-005453-4057qib7 11150 10 18 18 CD cord-005453-4057qib7 11150 11 patients patient NNS cord-005453-4057qib7 11150 12 maintained maintain VBD cord-005453-4057qib7 11150 13 positivity positivity NN cord-005453-4057qib7 11150 14 at at IN cord-005453-4057qib7 11150 15 day day NN cord-005453-4057qib7 11150 16 100 100 CD cord-005453-4057qib7 11150 17 after after IN cord-005453-4057qib7 11150 18 ASTC ASTC NNP cord-005453-4057qib7 11150 19 ( ( -LRB- cord-005453-4057qib7 11150 20 PET2 PET2 NNP cord-005453-4057qib7 11150 21 ) ) -RRB- cord-005453-4057qib7 11150 22 . . . cord-005453-4057qib7 11151 1 PFS PFS NNP cord-005453-4057qib7 11151 2 in in IN cord-005453-4057qib7 11151 3 patients patient NNS cord-005453-4057qib7 11151 4 with with IN cord-005453-4057qib7 11151 5 CT CT NNP cord-005453-4057qib7 11151 6 - - HYPH cord-005453-4057qib7 11151 7 PR PR NNP cord-005453-4057qib7 11151 8 was be VBD cord-005453-4057qib7 11151 9 46 46 CD cord-005453-4057qib7 11151 10 months month NNS cord-005453-4057qib7 11151 11 , , , cord-005453-4057qib7 11151 12 in in IN cord-005453-4057qib7 11151 13 PET1 PET1 NNP cord-005453-4057qib7 11151 14 positive positive JJ cord-005453-4057qib7 11151 15 ones one NNS cord-005453-4057qib7 11151 16 99 99 CD cord-005453-4057qib7 11151 17 months month NNS cord-005453-4057qib7 11151 18 and and CC cord-005453-4057qib7 11151 19 in in IN cord-005453-4057qib7 11151 20 PET2 PET2 NNP cord-005453-4057qib7 11151 21 positive positive JJ cord-005453-4057qib7 11151 22 ones one NNS cord-005453-4057qib7 11151 23 21 21 CD cord-005453-4057qib7 11151 24 months month NNS cord-005453-4057qib7 11151 25 . . . cord-005453-4057qib7 11152 1 Univariate Univariate NNP cord-005453-4057qib7 11152 2 analysis analysis NN cord-005453-4057qib7 11152 3 showed show VBD cord-005453-4057qib7 11152 4 PET2 PET2 NNP cord-005453-4057qib7 11152 5 positivity positivity NN cord-005453-4057qib7 11152 6 as as IN cord-005453-4057qib7 11152 7 the the DT cord-005453-4057qib7 11152 8 most most RBS cord-005453-4057qib7 11152 9 accurate accurate JJ cord-005453-4057qib7 11152 10 predictor predictor NN cord-005453-4057qib7 11152 11 of of IN cord-005453-4057qib7 11152 12 relapse relapse NN cord-005453-4057qib7 11152 13 ( ( -LRB- cord-005453-4057qib7 11152 14 HR HR NNP cord-005453-4057qib7 11152 15 3,13 3,13 NNP cord-005453-4057qib7 11152 16 , , , cord-005453-4057qib7 11152 17 p=0,004 p=0,004 NNP cord-005453-4057qib7 11152 18 ) ) -RRB- cord-005453-4057qib7 11152 19 followed follow VBN cord-005453-4057qib7 11152 20 by by IN cord-005453-4057qib7 11152 21 AMC AMC NNP cord-005453-4057qib7 11152 22 at at IN cord-005453-4057qib7 11152 23 day day NN cord-005453-4057qib7 11152 24 +100 +100 NNP cord-005453-4057qib7 11152 25 ( ( -LRB- cord-005453-4057qib7 11152 26 HR HR NNP cord-005453-4057qib7 11152 27 1,002 1,002 CD cord-005453-4057qib7 11152 28 , , , cord-005453-4057qib7 11152 29 p=0,13 p=0,13 NNP cord-005453-4057qib7 11152 30 ) ) -RRB- cord-005453-4057qib7 11152 31 , , , cord-005453-4057qib7 11152 32 albumin albumin NN cord-005453-4057qib7 11152 33 at at IN cord-005453-4057qib7 11152 34 day day NN cord-005453-4057qib7 11152 35 +100 +100 NNS cord-005453-4057qib7 11152 36 ( ( -LRB- cord-005453-4057qib7 11152 37 HR HR NNP cord-005453-4057qib7 11152 38 0,93 0,93 NN cord-005453-4057qib7 11152 39 , , , cord-005453-4057qib7 11152 40 p=0,03 p=0,03 NNP cord-005453-4057qib7 11152 41 ) ) -RRB- cord-005453-4057qib7 11152 42 , , , cord-005453-4057qib7 11152 43 LDH LDH NNP cord-005453-4057qib7 11152 44 at at IN cord-005453-4057qib7 11152 45 day day NN cord-005453-4057qib7 11152 46 +100 +100 NNP cord-005453-4057qib7 11152 47 ( ( -LRB- cord-005453-4057qib7 11152 48 HR HR NNP cord-005453-4057qib7 11152 49 1,002 1,002 CD cord-005453-4057qib7 11152 50 , , , cord-005453-4057qib7 11152 51 p p NN cord-005453-4057qib7 11152 52 < < XX cord-005453-4057qib7 11152 53 0,001 0,001 CD cord-005453-4057qib7 11152 54 ) ) -RRB- cord-005453-4057qib7 11152 55 and and CC cord-005453-4057qib7 11152 56 pretransplant pretransplant VB cord-005453-4057qib7 11152 57 ALC ALC NNP cord-005453-4057qib7 11152 58 / / SYM cord-005453-4057qib7 11152 59 AMC AMC NNP cord-005453-4057qib7 11152 60 ratio ratio NN cord-005453-4057qib7 11152 61 ( ( -LRB- cord-005453-4057qib7 11152 62 HR HR NNP cord-005453-4057qib7 11152 63 1,068 1,068 CD cord-005453-4057qib7 11152 64 p=0,008 p=0,008 NNP cord-005453-4057qib7 11152 65 ) ) -RRB- cord-005453-4057qib7 11152 66 . . . cord-005453-4057qib7 11153 1 Multivariate multivariate JJ cord-005453-4057qib7 11153 2 analysis analysis NN cord-005453-4057qib7 11153 3 only only RB cord-005453-4057qib7 11153 4 demonstrated demonstrate VBD cord-005453-4057qib7 11153 5 an an DT cord-005453-4057qib7 11153 6 association association NN cord-005453-4057qib7 11153 7 with with IN cord-005453-4057qib7 11153 8 PET2 PET2 NNP cord-005453-4057qib7 11153 9 positivity positivity NN cord-005453-4057qib7 11153 10 ( ( -LRB- cord-005453-4057qib7 11153 11 HR HR NNP cord-005453-4057qib7 11153 12 7,78 7,78 CD cord-005453-4057qib7 11153 13 ) ) -RRB- cord-005453-4057qib7 11154 1 p p NN cord-005453-4057qib7 11154 2 < < XX cord-005453-4057qib7 11154 3 001 001 CD cord-005453-4057qib7 11154 4 and and CC cord-005453-4057qib7 11154 5 LDH LDH NNP cord-005453-4057qib7 11154 6 in in IN cord-005453-4057qib7 11154 7 day day NN cord-005453-4057qib7 11154 8 +100 +100 NNS cord-005453-4057qib7 11154 9 ( ( -LRB- cord-005453-4057qib7 11154 10 HR HR NNP cord-005453-4057qib7 11154 11 1,008 1,008 CD cord-005453-4057qib7 11154 12 ) ) -RRB- cord-005453-4057qib7 11154 13 p=0,003 p=0,003 VBP cord-005453-4057qib7 11154 14 with with IN cord-005453-4057qib7 11154 15 PFS PFS NNP cord-005453-4057qib7 11154 16 . . . cord-005453-4057qib7 11155 1 Five five CD cord-005453-4057qib7 11155 2 and and CC cord-005453-4057qib7 11155 3 ten ten CD cord-005453-4057qib7 11155 4 years year NNS cord-005453-4057qib7 11155 5 overall overall JJ cord-005453-4057qib7 11155 6 survival survival NN cord-005453-4057qib7 11155 7 were be VBD cord-005453-4057qib7 11155 8 61 61 CD cord-005453-4057qib7 11155 9 % % NN cord-005453-4057qib7 11155 10 and and CC cord-005453-4057qib7 11155 11 37 37 CD cord-005453-4057qib7 11155 12 % % NN cord-005453-4057qib7 11155 13 in in IN cord-005453-4057qib7 11155 14 PET2 PET2 NNP cord-005453-4057qib7 11155 15 negative negative JJ cord-005453-4057qib7 11155 16 patients patient NNS cord-005453-4057qib7 11155 17 vs vs IN cord-005453-4057qib7 11155 18 25 25 CD cord-005453-4057qib7 11155 19 and and CC cord-005453-4057qib7 11155 20 5 5 CD cord-005453-4057qib7 11155 21 % % NN cord-005453-4057qib7 11155 22 in in IN cord-005453-4057qib7 11155 23 PET2 PET2 NNP cord-005453-4057qib7 11155 24 positive positive JJ cord-005453-4057qib7 11155 25 ones one NNS cord-005453-4057qib7 11156 1 ( ( -LRB- cord-005453-4057qib7 11156 2 p p NN cord-005453-4057qib7 11156 3 < < XX cord-005453-4057qib7 11156 4 0,01 0,01 NN cord-005453-4057qib7 11156 5 ) ) -RRB- cord-005453-4057qib7 11156 6 . . . cord-005453-4057qib7 11157 1 Eight eight CD cord-005453-4057qib7 11157 2 out out IN cord-005453-4057qib7 11157 3 of of IN cord-005453-4057qib7 11157 4 19 19 CD cord-005453-4057qib7 11157 5 patients patient NNS cord-005453-4057qib7 11157 6 with with IN cord-005453-4057qib7 11157 7 PET2 PET2 NNP cord-005453-4057qib7 11157 8 positivity positivity NN cord-005453-4057qib7 11157 9 did do VBD cord-005453-4057qib7 11157 10 not not RB cord-005453-4057qib7 11157 11 relapse relapse VB cord-005453-4057qib7 11157 12 . . . cord-005453-4057qib7 11158 1 Salvage salvage NN cord-005453-4057qib7 11158 2 radiation radiation NN cord-005453-4057qib7 11158 3 therapy therapy NN cord-005453-4057qib7 11158 4 was be VBD cord-005453-4057qib7 11158 5 used use VBN cord-005453-4057qib7 11158 6 in in IN cord-005453-4057qib7 11158 7 7 7 CD cord-005453-4057qib7 11158 8 patients patient NNS cord-005453-4057qib7 11158 9 with with IN cord-005453-4057qib7 11158 10 positive positive JJ cord-005453-4057qib7 11158 11 residual residual JJ cord-005453-4057qib7 11158 12 mass mass NN cord-005453-4057qib7 11158 13 and and CC cord-005453-4057qib7 11158 14 5 5 CD cord-005453-4057qib7 11158 15 of of IN cord-005453-4057qib7 11158 16 them -PRON- PRP cord-005453-4057qib7 11158 17 did do VBD cord-005453-4057qib7 11158 18 not not RB cord-005453-4057qib7 11158 19 relapse relapse VB cord-005453-4057qib7 11158 20 . . . cord-005453-4057qib7 11159 1 Two two CD cord-005453-4057qib7 11159 2 patients patient NNS cord-005453-4057qib7 11159 3 relapsed relapse VBD cord-005453-4057qib7 11159 4 : : : cord-005453-4057qib7 11160 1 one one CD cord-005453-4057qib7 11160 2 patient patient NN cord-005453-4057qib7 11160 3 had have VBD cord-005453-4057qib7 11160 4 residual residual JJ cord-005453-4057qib7 11160 5 mass mass NN cord-005453-4057qib7 11160 6 and and CC cord-005453-4057qib7 11160 7 another another DT cord-005453-4057qib7 11160 8 had have VBD cord-005453-4057qib7 11160 9 remote remote JJ cord-005453-4057qib7 11160 10 affectation affectation NN cord-005453-4057qib7 11160 11 from from IN cord-005453-4057qib7 11160 12 primary primary JJ cord-005453-4057qib7 11160 13 site site NN cord-005453-4057qib7 11160 14 and and CC cord-005453-4057qib7 11160 15 could could MD cord-005453-4057qib7 11160 16 be be VB cord-005453-4057qib7 11160 17 considered consider VBN cord-005453-4057qib7 11160 18 as as IN cord-005453-4057qib7 11160 19 progression progression NN cord-005453-4057qib7 11160 20 before before IN cord-005453-4057qib7 11160 21 day day NN cord-005453-4057qib7 11160 22 +100 +100 NNS cord-005453-4057qib7 11160 23 . . . cord-005453-4057qib7 11161 1 Conclusions conclusion NNS cord-005453-4057qib7 11161 2 : : : cord-005453-4057qib7 11162 1 Post Post NNP cord-005453-4057qib7 11162 2 ASCT ASCT NNP cord-005453-4057qib7 11163 1 FDGPET/ FDGPET/ NNP cord-005453-4057qib7 11163 2 CT CT NNP cord-005453-4057qib7 11163 3 is be VBZ cord-005453-4057qib7 11163 4 superior superior JJ cord-005453-4057qib7 11163 5 to to IN cord-005453-4057qib7 11163 6 conventional conventional JJ cord-005453-4057qib7 11163 7 CT CT NNP cord-005453-4057qib7 11163 8 in in IN cord-005453-4057qib7 11163 9 predicting predict VBG cord-005453-4057qib7 11163 10 outcome outcome NN cord-005453-4057qib7 11163 11 in in IN cord-005453-4057qib7 11163 12 aggressive aggressive JJ cord-005453-4057qib7 11163 13 lymphoma lymphoma NN cord-005453-4057qib7 11163 14 after after IN cord-005453-4057qib7 11163 15 ASTC ASTC NNP cord-005453-4057qib7 11163 16 . . . cord-005453-4057qib7 11164 1 Pre pre JJ cord-005453-4057qib7 11164 2 and and CC cord-005453-4057qib7 11164 3 post post VB cord-005453-4057qib7 11164 4 ASCT asct JJ cord-005453-4057qib7 11164 5 systemic systemic JJ cord-005453-4057qib7 11164 6 inflammatory inflammatory JJ cord-005453-4057qib7 11164 7 parameters parameter NNS cord-005453-4057qib7 11164 8 did do VBD cord-005453-4057qib7 11164 9 n't not RB cord-005453-4057qib7 11164 10 help help NN cord-005453-4057qib7 11164 11 to to TO cord-005453-4057qib7 11164 12 improve improve VB cord-005453-4057qib7 11164 13 the the DT cord-005453-4057qib7 11164 14 relapse relapse NN cord-005453-4057qib7 11164 15 risk risk NN cord-005453-4057qib7 11164 16 prediction prediction NN cord-005453-4057qib7 11164 17 . . . cord-005453-4057qib7 11165 1 Addition addition NN cord-005453-4057qib7 11165 2 of of IN cord-005453-4057qib7 11165 3 consolidative consolidative JJ cord-005453-4057qib7 11165 4 RT RT NNP cord-005453-4057qib7 11165 5 after after IN cord-005453-4057qib7 11165 6 ASTC ASTC NNP cord-005453-4057qib7 11165 7 has have VBZ cord-005453-4057qib7 11165 8 demonstrated demonstrate VBN cord-005453-4057qib7 11165 9 improvement improvement NN cord-005453-4057qib7 11165 10 in in IN cord-005453-4057qib7 11165 11 PFS PFS NNP cord-005453-4057qib7 11165 12 in in IN cord-005453-4057qib7 11165 13 patients patient NNS cord-005453-4057qib7 11165 14 with with IN cord-005453-4057qib7 11165 15 PET pet JJ cord-005453-4057qib7 11165 16 positivity positivity NN cord-005453-4057qib7 11165 17 . . . cord-005453-4057qib7 11166 1 It -PRON- PRP cord-005453-4057qib7 11166 2 would would MD cord-005453-4057qib7 11166 3 be be VB cord-005453-4057qib7 11166 4 neccesary neccesary JJ cord-005453-4057qib7 11166 5 to to TO cord-005453-4057qib7 11166 6 develop develop VB cord-005453-4057qib7 11166 7 randomized randomized JJ cord-005453-4057qib7 11166 8 trials trial NNS cord-005453-4057qib7 11166 9 to to TO cord-005453-4057qib7 11166 10 assess assess VB cord-005453-4057qib7 11166 11 the the DT cord-005453-4057qib7 11166 12 role role NN cord-005453-4057qib7 11166 13 of of IN cord-005453-4057qib7 11166 14 RT RT NNP cord-005453-4057qib7 11166 15 in in IN cord-005453-4057qib7 11166 16 residual residual JJ cord-005453-4057qib7 11166 17 disease disease NN cord-005453-4057qib7 11166 18 in in IN cord-005453-4057qib7 11166 19 advanced advanced JJ cord-005453-4057qib7 11166 20 aggressive aggressive JJ cord-005453-4057qib7 11166 21 NHL NHL NNP cord-005453-4057qib7 11166 22 with with IN cord-005453-4057qib7 11166 23 insufficient insufficient JJ cord-005453-4057qib7 11166 24 response response NN cord-005453-4057qib7 11166 25 to to IN cord-005453-4057qib7 11166 26 systemic systemic JJ cord-005453-4057qib7 11166 27 treatment treatment NN cord-005453-4057qib7 11166 28 with with IN cord-005453-4057qib7 11166 29 PET pet JJ cord-005453-4057qib7 11166 30 response response NN cord-005453-4057qib7 11166 31 evaluation evaluation NN cord-005453-4057qib7 11166 32 . . . cord-005453-4057qib7 11167 1 Disclosure disclosure NN cord-005453-4057qib7 11167 2 : : : cord-005453-4057qib7 11167 3 Nothing nothing NN cord-005453-4057qib7 11167 4 to to TO cord-005453-4057qib7 11167 5 declare declare VB cord-005453-4057qib7 11167 6 Long long JJ cord-005453-4057qib7 11167 7 term term NN cord-005453-4057qib7 11167 8 outcome outcome NN cord-005453-4057qib7 11167 9 of of IN cord-005453-4057qib7 11167 10 patients patient NNS cord-005453-4057qib7 11167 11 with with IN cord-005453-4057qib7 11167 12 lymphoid lymphoid JJ cord-005453-4057qib7 11167 13 malignancy malignancy NN cord-005453-4057qib7 11167 14 who who WP cord-005453-4057qib7 11167 15 underwent undergo VBD cord-005453-4057qib7 11167 16 high high JJ cord-005453-4057qib7 11167 17 dose dose NN cord-005453-4057qib7 11168 1 chemotherapy chemotherapy NN cord-005453-4057qib7 11168 2 followed follow VBD cord-005453-4057qib7 11168 3 autologous autologous JJ cord-005453-4057qib7 11168 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 11168 5 cell cell NN cord-005453-4057qib7 11168 6 transplantation transplantation NN cord-005453-4057qib7 11168 7 at at IN cord-005453-4057qib7 11168 8 a a DT cord-005453-4057qib7 11168 9 single single JJ cord-005453-4057qib7 11168 10 institution institution NN cord-005453-4057qib7 11168 11 over over IN cord-005453-4057qib7 11168 12 20 20 CD cord-005453-4057qib7 11168 13 years year NNS cord-005453-4057qib7 11168 14 Joanna Joanna NNP cord-005453-4057qib7 11168 15 Romejko Romejko NNP cord-005453-4057qib7 11168 16 - - HYPH cord-005453-4057qib7 11168 17 Jarosinska Jarosinska NNP cord-005453-4057qib7 11168 18 1 1 CD cord-005453-4057qib7 11168 19 , , , cord-005453-4057qib7 11168 20 Ewa Ewa NNP cord-005453-4057qib7 11168 21 Paszkiewicz Paszkiewicz NNP cord-005453-4057qib7 11168 22 - - HYPH cord-005453-4057qib7 11168 23 Kozik Kozik NNP cord-005453-4057qib7 11168 24 1 1 CD cord-005453-4057qib7 11168 25 , , , cord-005453-4057qib7 11168 26 Lukasz Lukasz NNP cord-005453-4057qib7 11168 27 Targonski Targonski NNP cord-005453-4057qib7 11168 28 1 1 CD cord-005453-4057qib7 11168 29 , , , cord-005453-4057qib7 11168 30 Lidia Lidia NNP cord-005453-4057qib7 11168 31 Popławska Popławska NNP cord-005453-4057qib7 11168 32 1 1 CD cord-005453-4057qib7 11168 33 , , , cord-005453-4057qib7 11168 34 Jan Jan NNP cord-005453-4057qib7 11168 35 Walewski Walewski NNP cord-005453-4057qib7 11168 36 1 1 CD cord-005453-4057qib7 11168 37 Background Background NNP cord-005453-4057qib7 11168 38 : : : cord-005453-4057qib7 11169 1 High high JJ cord-005453-4057qib7 11169 2 dose dose NN cord-005453-4057qib7 11169 3 chemotherapy chemotherapy NN cord-005453-4057qib7 11169 4 ( ( -LRB- cord-005453-4057qib7 11169 5 HDT HDT NNP cord-005453-4057qib7 11169 6 ) ) -RRB- cord-005453-4057qib7 11169 7 and and CC cord-005453-4057qib7 11169 8 autologous autologous JJ cord-005453-4057qib7 11169 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 11169 10 cell cell NN cord-005453-4057qib7 11169 11 transplantation transplantation NN cord-005453-4057qib7 11169 12 ( ( -LRB- cord-005453-4057qib7 11169 13 auto auto NN cord-005453-4057qib7 11169 14 - - HYPH cord-005453-4057qib7 11169 15 HCT HCT NNP cord-005453-4057qib7 11169 16 ) ) -RRB- cord-005453-4057qib7 11169 17 is be VBZ cord-005453-4057qib7 11169 18 a a DT cord-005453-4057qib7 11169 19 standard standard NN cord-005453-4057qib7 11169 20 of of IN cord-005453-4057qib7 11169 21 care care NN cord-005453-4057qib7 11169 22 for for IN cord-005453-4057qib7 11169 23 relapsed relapsed JJ cord-005453-4057qib7 11169 24 / / SYM cord-005453-4057qib7 11169 25 refractory refractory JJ cord-005453-4057qib7 11169 26 lymphoma lymphoma NN cord-005453-4057qib7 11169 27 patients patient NNS cord-005453-4057qib7 11169 28 ( ( -LRB- cord-005453-4057qib7 11169 29 pts pts NNP cord-005453-4057qib7 11169 30 ) ) -RRB- cord-005453-4057qib7 11169 31 or or CC cord-005453-4057qib7 11169 32 it -PRON- PRP cord-005453-4057qib7 11169 33 is be VBZ cord-005453-4057qib7 11169 34 used use VBN cord-005453-4057qib7 11169 35 as as IN cord-005453-4057qib7 11169 36 a a DT cord-005453-4057qib7 11169 37 consolidation consolidation NN cord-005453-4057qib7 11169 38 for for IN cord-005453-4057qib7 11169 39 myeloma myeloma NN cord-005453-4057qib7 11169 40 and and CC cord-005453-4057qib7 11169 41 high high JJ cord-005453-4057qib7 11169 42 risk risk NN cord-005453-4057qib7 11169 43 lymphoma lymphoma NN cord-005453-4057qib7 11169 44 patients patient NNS cord-005453-4057qib7 11169 45 in in IN cord-005453-4057qib7 11169 46 first first JJ cord-005453-4057qib7 11169 47 line line NN cord-005453-4057qib7 11169 48 treatment treatment NN cord-005453-4057qib7 11169 49 . . . cord-005453-4057qib7 11170 1 We -PRON- PRP cord-005453-4057qib7 11170 2 retrospectively retrospectively RB cord-005453-4057qib7 11170 3 evaluated evaluate VBD cord-005453-4057qib7 11170 4 long long JJ cord-005453-4057qib7 11170 5 - - HYPH cord-005453-4057qib7 11170 6 term term NN cord-005453-4057qib7 11170 7 outcome outcome NN cord-005453-4057qib7 11170 8 including include VBG cord-005453-4057qib7 11170 9 late late JJ cord-005453-4057qib7 11170 10 effects effect NNS cord-005453-4057qib7 11170 11 and and CC cord-005453-4057qib7 11170 12 risk risk NN cord-005453-4057qib7 11170 13 factors factor NNS cord-005453-4057qib7 11170 14 in in IN cord-005453-4057qib7 11170 15 patients patient NNS cord-005453-4057qib7 11170 16 with with IN cord-005453-4057qib7 11170 17 lymphoid lymphoid JJ cord-005453-4057qib7 11170 18 malignancy malignancy NN cord-005453-4057qib7 11170 19 who who WP cord-005453-4057qib7 11170 20 underwent undergo VBD cord-005453-4057qib7 11170 21 auto auto NN cord-005453-4057qib7 11170 22 - - HYPH cord-005453-4057qib7 11170 23 HCT hct NN cord-005453-4057qib7 11170 24 . . . cord-005453-4057qib7 11171 1 Methods method NNS cord-005453-4057qib7 11171 2 : : : cord-005453-4057qib7 11172 1 We -PRON- PRP cord-005453-4057qib7 11172 2 collected collect VBD cord-005453-4057qib7 11172 3 data datum NNS cord-005453-4057qib7 11172 4 from from IN cord-005453-4057qib7 11172 5 926 926 CD cord-005453-4057qib7 11172 6 consecutive consecutive JJ cord-005453-4057qib7 11172 7 patients patient NNS cord-005453-4057qib7 11172 8 with with IN cord-005453-4057qib7 11172 9 Hodgkin Hodgkin NNP cord-005453-4057qib7 11172 10 lymphoma lymphoma NN cord-005453-4057qib7 11172 11 ( ( -LRB- cord-005453-4057qib7 11172 12 HL HL NNP cord-005453-4057qib7 11172 13 ) ) -RRB- cord-005453-4057qib7 11172 14 ( ( -LRB- cord-005453-4057qib7 11172 15 n=326 n=326 NNP cord-005453-4057qib7 11172 16 ) ) -RRB- cord-005453-4057qib7 11172 17 , , , cord-005453-4057qib7 11172 18 aggressive aggressive JJ cord-005453-4057qib7 11172 19 B b NN cord-005453-4057qib7 11172 20 lymphoma lymphoma NN cord-005453-4057qib7 11172 21 ( ( -LRB- cord-005453-4057qib7 11172 22 DLBCL DLBCL NNP cord-005453-4057qib7 11172 23 ) ) -RRB- cord-005453-4057qib7 11172 24 ( ( -LRB- cord-005453-4057qib7 11172 25 n=186 n=186 NNP cord-005453-4057qib7 11172 26 ) ) -RRB- cord-005453-4057qib7 11172 27 , , , cord-005453-4057qib7 11172 28 myeloma myeloma NN cord-005453-4057qib7 11172 29 ( ( -LRB- cord-005453-4057qib7 11172 30 n=199 n=199 NNP cord-005453-4057qib7 11172 31 ) ) -RRB- cord-005453-4057qib7 11172 32 , , , cord-005453-4057qib7 11172 33 indolent indolent JJ cord-005453-4057qib7 11172 34 lymphoma lymphoma NN cord-005453-4057qib7 11172 35 ( ( -LRB- cord-005453-4057qib7 11172 36 n=30 n=30 NNP cord-005453-4057qib7 11172 37 ) ) -RRB- cord-005453-4057qib7 11172 38 , , , cord-005453-4057qib7 11172 39 mantle mantle NN cord-005453-4057qib7 11172 40 cell cell NN cord-005453-4057qib7 11172 41 lymphoma lymphoma NN cord-005453-4057qib7 11172 42 ( ( -LRB- cord-005453-4057qib7 11172 43 n=122 n=122 NNP cord-005453-4057qib7 11172 44 ) ) -RRB- cord-005453-4057qib7 11172 45 and and CC cord-005453-4057qib7 11172 46 peripheral peripheral JJ cord-005453-4057qib7 11172 47 T T NNP cord-005453-4057qib7 11172 48 cell cell NN cord-005453-4057qib7 11172 49 lymphoma lymphoma NN cord-005453-4057qib7 11172 50 ( ( -LRB- cord-005453-4057qib7 11172 51 n=63 n=63 NNP cord-005453-4057qib7 11172 52 ) ) -RRB- cord-005453-4057qib7 11172 53 who who WP cord-005453-4057qib7 11172 54 underwent undergo VBD cord-005453-4057qib7 11172 55 auto auto NN cord-005453-4057qib7 11172 56 - - HYPH cord-005453-4057qib7 11172 57 HCT hct NN cord-005453-4057qib7 11172 58 at at IN cord-005453-4057qib7 11172 59 our -PRON- PRP$ cord-005453-4057qib7 11172 60 institution institution NN cord-005453-4057qib7 11172 61 between between IN cord-005453-4057qib7 11172 62 1997 1997 CD cord-005453-4057qib7 11172 63 and and CC cord-005453-4057qib7 11172 64 2017 2017 CD cord-005453-4057qib7 11172 65 . . . cord-005453-4057qib7 11173 1 At at IN cord-005453-4057qib7 11173 2 transplant transplant NN cord-005453-4057qib7 11173 3 median median NN cord-005453-4057qib7 11173 4 ( ( -LRB- cord-005453-4057qib7 11173 5 range range NN cord-005453-4057qib7 11173 6 ) ) -RRB- cord-005453-4057qib7 11173 7 age age NN cord-005453-4057qib7 11173 8 was be VBD cord-005453-4057qib7 11173 9 46 46 CD cord-005453-4057qib7 11174 1 ( ( -LRB- cord-005453-4057qib7 11174 2 17 17 CD cord-005453-4057qib7 11174 3 - - SYM cord-005453-4057qib7 11174 4 71 71 CD cord-005453-4057qib7 11174 5 ) ) -RRB- cord-005453-4057qib7 11174 6 years year NNS cord-005453-4057qib7 11174 7 , , , cord-005453-4057qib7 11174 8 clinical clinical JJ cord-005453-4057qib7 11174 9 stage stage NN cord-005453-4057qib7 11174 10 III III NNP cord-005453-4057qib7 11174 11 / / SYM cord-005453-4057qib7 11174 12 IV IV NNP cord-005453-4057qib7 11174 13 was be VBD cord-005453-4057qib7 11174 14 found find VBN cord-005453-4057qib7 11174 15 in in IN cord-005453-4057qib7 11174 16 499 499 CD cord-005453-4057qib7 11174 17 of of IN cord-005453-4057qib7 11174 18 lymphoma lymphoma NN cord-005453-4057qib7 11174 19 pts pts NN cord-005453-4057qib7 11174 20 , , , cord-005453-4057qib7 11174 21 complete complete JJ cord-005453-4057qib7 11174 22 remission remission NN cord-005453-4057qib7 11174 23 , , , cord-005453-4057qib7 11174 24 partial partial JJ cord-005453-4057qib7 11174 25 remission remission NN cord-005453-4057qib7 11174 26 and and CC cord-005453-4057qib7 11174 27 stable/ stable/ CD cord-005453-4057qib7 11174 28 progressive progressive JJ cord-005453-4057qib7 11174 29 disease disease NN cord-005453-4057qib7 11174 30 occurred occur VBD cord-005453-4057qib7 11174 31 in in IN cord-005453-4057qib7 11174 32 462(50 462(50 CD cord-005453-4057qib7 11174 33 % % NN cord-005453-4057qib7 11174 34 ) ) -RRB- cord-005453-4057qib7 11174 35 , , , cord-005453-4057qib7 11174 36 397 397 CD cord-005453-4057qib7 11174 37 ( ( -LRB- cord-005453-4057qib7 11174 38 43 43 CD cord-005453-4057qib7 11174 39 % % NN cord-005453-4057qib7 11174 40 ) ) -RRB- cord-005453-4057qib7 11174 41 , , , cord-005453-4057qib7 11174 42 67 67 CD cord-005453-4057qib7 11174 43 ( ( -LRB- cord-005453-4057qib7 11174 44 7 7 CD cord-005453-4057qib7 11174 45 % % NN cord-005453-4057qib7 11174 46 ) ) -RRB- cord-005453-4057qib7 11174 47 pts pt NNS cord-005453-4057qib7 11174 48 , , , cord-005453-4057qib7 11174 49 respectively respectively RB cord-005453-4057qib7 11174 50 . . . cord-005453-4057qib7 11175 1 BEAM BEAM NNP cord-005453-4057qib7 11175 2 regimen regimen NN cord-005453-4057qib7 11175 3 was be VBD cord-005453-4057qib7 11175 4 used use VBN cord-005453-4057qib7 11175 5 in in IN cord-005453-4057qib7 11175 6 549 549 CD cord-005453-4057qib7 11175 7 pts pt NNS cord-005453-4057qib7 11175 8 ( ( -LRB- cord-005453-4057qib7 11175 9 59 59 CD cord-005453-4057qib7 11175 10 % % NN cord-005453-4057qib7 11175 11 ) ) -RRB- cord-005453-4057qib7 11175 12 , , , cord-005453-4057qib7 11175 13 Mel200 mel200 NN cord-005453-4057qib7 11175 14 in in IN cord-005453-4057qib7 11175 15 200 200 CD cord-005453-4057qib7 11175 16 pts pt NNS cord-005453-4057qib7 11175 17 ( ( -LRB- cord-005453-4057qib7 11175 18 23 23 CD cord-005453-4057qib7 11175 19 % % NN cord-005453-4057qib7 11175 20 ) ) -RRB- cord-005453-4057qib7 11175 21 and and CC cord-005453-4057qib7 11175 22 other other JJ cord-005453-4057qib7 11175 23 myeloablative myeloablative JJ cord-005453-4057qib7 11175 24 regimens regimen NNS cord-005453-4057qib7 11175 25 in in IN cord-005453-4057qib7 11175 26 177 177 CD cord-005453-4057qib7 11175 27 pts pt NNS cord-005453-4057qib7 11175 28 ( ( -LRB- cord-005453-4057qib7 11175 29 18 18 CD cord-005453-4057qib7 11175 30 % % NN cord-005453-4057qib7 11175 31 ) ) -RRB- cord-005453-4057qib7 11175 32 . . . cord-005453-4057qib7 11176 1 Results result NNS cord-005453-4057qib7 11176 2 62 62 CD cord-005453-4057qib7 11176 3 % % NN cord-005453-4057qib7 11176 4 ) ) -RRB- cord-005453-4057qib7 11176 5 ] ] -RRB- cord-005453-4057qib7 11176 6 , , , cord-005453-4057qib7 11176 7 respectively respectively RB cord-005453-4057qib7 11176 8 . . . cord-005453-4057qib7 11177 1 Partial partial JJ cord-005453-4057qib7 11177 2 remission remission NN cord-005453-4057qib7 11177 3 or or CC cord-005453-4057qib7 11177 4 stable stable JJ cord-005453-4057qib7 11177 5 disease disease NN cord-005453-4057qib7 11177 6 at at IN cord-005453-4057qib7 11177 7 transplant transplant NN cord-005453-4057qib7 11177 8 , , , cord-005453-4057qib7 11177 9 clinical clinical JJ cord-005453-4057qib7 11177 10 stage stage NN cord-005453-4057qib7 11177 11 III III NNP cord-005453-4057qib7 11177 12 or or CC cord-005453-4057qib7 11177 13 IV IV NNP cord-005453-4057qib7 11177 14 , , , cord-005453-4057qib7 11177 15 and and CC cord-005453-4057qib7 11177 16 age age NN cord-005453-4057qib7 11177 17 more more JJR cord-005453-4057qib7 11177 18 than than IN cord-005453-4057qib7 11177 19 60 60 CD cord-005453-4057qib7 11177 20 , , , cord-005453-4057qib7 11177 21 were be VBD cord-005453-4057qib7 11177 22 identified identify VBN cord-005453-4057qib7 11177 23 as as IN cord-005453-4057qib7 11177 24 risk risk NN cord-005453-4057qib7 11177 25 factors factor NNS cord-005453-4057qib7 11177 26 associated associate VBN cord-005453-4057qib7 11177 27 with with IN cord-005453-4057qib7 11177 28 inferior inferior JJ cord-005453-4057qib7 11177 29 OS OS NNP cord-005453-4057qib7 11177 30 and and CC cord-005453-4057qib7 11177 31 PFS PFS NNP cord-005453-4057qib7 11177 32 in in IN cord-005453-4057qib7 11177 33 univariate univariate JJ cord-005453-4057qib7 11177 34 and and CC cord-005453-4057qib7 11177 35 multivariate multivariate JJ cord-005453-4057qib7 11177 36 analysis analysis NN cord-005453-4057qib7 11177 37 . . . cord-005453-4057qib7 11178 1 Histopathologic Histopathologic NNP cord-005453-4057qib7 11178 2 diagnosis diagnosis NN cord-005453-4057qib7 11178 3 was be VBD cord-005453-4057qib7 11178 4 not not RB cord-005453-4057qib7 11178 5 a a DT cord-005453-4057qib7 11178 6 risk risk NN cord-005453-4057qib7 11178 7 factor factor NN cord-005453-4057qib7 11178 8 for for IN cord-005453-4057qib7 11178 9 OS OS NNP cord-005453-4057qib7 11178 10 and and CC cord-005453-4057qib7 11178 11 PFS PFS NNP cord-005453-4057qib7 11178 12 ( ( -LRB- cord-005453-4057qib7 11178 13 p p NN cord-005453-4057qib7 11178 14 = = SYM cord-005453-4057qib7 11178 15 NS NS NNP cord-005453-4057qib7 11178 16 ) ) -RRB- cord-005453-4057qib7 11178 17 . . . cord-005453-4057qib7 11179 1 The the DT cord-005453-4057qib7 11179 2 outcome outcome NN cord-005453-4057qib7 11179 3 of of IN cord-005453-4057qib7 11179 4 patients patient NNS cord-005453-4057qib7 11179 5 who who WP cord-005453-4057qib7 11179 6 underwent undergo VBD cord-005453-4057qib7 11179 7 auto auto NN cord-005453-4057qib7 11179 8 - - HYPH cord-005453-4057qib7 11179 9 HCT hct NN cord-005453-4057qib7 11179 10 between between IN cord-005453-4057qib7 11179 11 1997 1997 CD cord-005453-4057qib7 11179 12 - - SYM cord-005453-4057qib7 11179 13 2003 2003 CD cord-005453-4057qib7 11179 14 was be VBD cord-005453-4057qib7 11179 15 inferior inferior JJ cord-005453-4057qib7 11179 16 to to IN cord-005453-4057qib7 11179 17 the the DT cord-005453-4057qib7 11179 18 outcome outcome NN cord-005453-4057qib7 11179 19 of of IN cord-005453-4057qib7 11179 20 patients patient NNS cord-005453-4057qib7 11179 21 treated treat VBN cord-005453-4057qib7 11179 22 in in IN cord-005453-4057qib7 11179 23 2004 2004 CD cord-005453-4057qib7 11179 24 - - SYM cord-005453-4057qib7 11179 25 2010 2010 CD cord-005453-4057qib7 11179 26 or or CC cord-005453-4057qib7 11179 27 2011 2011 CD cord-005453-4057qib7 11179 28 - - SYM cord-005453-4057qib7 11179 29 2017 2017 CD cord-005453-4057qib7 11179 30 . . . cord-005453-4057qib7 11180 1 5- 5- CD cord-005453-4057qib7 11180 2 year year NN cord-005453-4057qib7 11180 3 OS OS NNP cord-005453-4057qib7 11180 4 was be VBD cord-005453-4057qib7 11180 5 53 53 CD cord-005453-4057qib7 11180 6 % % NN cord-005453-4057qib7 11180 7 , , , cord-005453-4057qib7 11180 8 68 68 CD cord-005453-4057qib7 11180 9 % % NN cord-005453-4057qib7 11180 10 , , , cord-005453-4057qib7 11180 11 73%(p 73%(p CD cord-005453-4057qib7 11180 12 < < XX cord-005453-4057qib7 11180 13 0.001 0.001 CD cord-005453-4057qib7 11180 14 ) ) -RRB- cord-005453-4057qib7 11180 15 and and CC cord-005453-4057qib7 11180 16 5 5 CD cord-005453-4057qib7 11180 17 year year NN cord-005453-4057qib7 11180 18 PFS PFS NNP cord-005453-4057qib7 11180 19 was be VBD cord-005453-4057qib7 11180 20 43 43 CD cord-005453-4057qib7 11180 21 % % NN cord-005453-4057qib7 11180 22 , , , cord-005453-4057qib7 11180 23 54 54 CD cord-005453-4057qib7 11180 24 % % NN cord-005453-4057qib7 11180 25 , , , cord-005453-4057qib7 11180 26 55 55 CD cord-005453-4057qib7 11180 27 % % NN cord-005453-4057qib7 11180 28 ( ( -LRB- cord-005453-4057qib7 11180 29 p p NN cord-005453-4057qib7 11180 30 < < XX cord-005453-4057qib7 11180 31 0.01 0.01 CD cord-005453-4057qib7 11180 32 ) ) -RRB- cord-005453-4057qib7 11180 33 , , , cord-005453-4057qib7 11180 34 respectively respectively RB cord-005453-4057qib7 11180 35 . . . cord-005453-4057qib7 11181 1 We -PRON- PRP cord-005453-4057qib7 11181 2 recorded record VBD cord-005453-4057qib7 11181 3 37 37 CD cord-005453-4057qib7 11181 4 ( ( -LRB- cord-005453-4057qib7 11181 5 4 4 CD cord-005453-4057qib7 11181 6 % % NN cord-005453-4057qib7 11181 7 ) ) -RRB- cord-005453-4057qib7 11181 8 cases case NNS cord-005453-4057qib7 11181 9 of of IN cord-005453-4057qib7 11181 10 second second JJ cord-005453-4057qib7 11181 11 primary primary JJ cord-005453-4057qib7 11181 12 cancer cancer NN cord-005453-4057qib7 11181 13 ( ( -LRB- cord-005453-4057qib7 11181 14 18 18 CD cord-005453-4057qib7 11181 15 solid solid JJ cord-005453-4057qib7 11181 16 tumors tumor NNS cord-005453-4057qib7 11181 17 and and CC cord-005453-4057qib7 11181 18 19 19 CD cord-005453-4057qib7 11181 19 hematologic hematologic JJ cord-005453-4057qib7 11181 20 cancers cancer NNS cord-005453-4057qib7 11181 21 ) ) -RRB- cord-005453-4057qib7 11181 22 . . . cord-005453-4057qib7 11182 1 Acute acute JJ cord-005453-4057qib7 11182 2 cardiotoxicity cardiotoxicity NN cord-005453-4057qib7 11182 3 occurred occur VBD cord-005453-4057qib7 11182 4 in in IN cord-005453-4057qib7 11182 5 5 5 CD cord-005453-4057qib7 11182 6 patients patient NNS cord-005453-4057qib7 11182 7 from from IN cord-005453-4057qib7 11182 8 1 1 CD cord-005453-4057qib7 11182 9 to to IN cord-005453-4057qib7 11182 10 15 15 CD cord-005453-4057qib7 11182 11 years year NNS cord-005453-4057qib7 11182 12 after after IN cord-005453-4057qib7 11182 13 transplant transplant NN cord-005453-4057qib7 11182 14 , , , cord-005453-4057qib7 11182 15 and and CC cord-005453-4057qib7 11182 16 required require VBD cord-005453-4057qib7 11182 17 heart heart NN cord-005453-4057qib7 11182 18 transplant transplant NN cord-005453-4057qib7 11182 19 in in IN cord-005453-4057qib7 11182 20 2 2 CD cord-005453-4057qib7 11182 21 patients patient NNS cord-005453-4057qib7 11182 22 . . . cord-005453-4057qib7 11183 1 326 326 CD cord-005453-4057qib7 11183 2 patients patient NNS cord-005453-4057qib7 11183 3 ( ( -LRB- cord-005453-4057qib7 11183 4 35 35 CD cord-005453-4057qib7 11183 5 % % NN cord-005453-4057qib7 11183 6 ) ) -RRB- cord-005453-4057qib7 11183 7 died die VBD cord-005453-4057qib7 11183 8 . . . cord-005453-4057qib7 11184 1 The the DT cord-005453-4057qib7 11184 2 main main JJ cord-005453-4057qib7 11184 3 causes cause NNS cord-005453-4057qib7 11184 4 of of IN cord-005453-4057qib7 11184 5 death death NN cord-005453-4057qib7 11184 6 were be VBD cord-005453-4057qib7 11184 7 progressive progressive JJ cord-005453-4057qib7 11184 8 disease disease NN cord-005453-4057qib7 11184 9 in in IN cord-005453-4057qib7 11184 10 271 271 CD cord-005453-4057qib7 11184 11 pts pt NNS cord-005453-4057qib7 11184 12 ( ( -LRB- cord-005453-4057qib7 11184 13 89 89 CD cord-005453-4057qib7 11184 14 % % NN cord-005453-4057qib7 11184 15 ) ) -RRB- cord-005453-4057qib7 11184 16 , , , cord-005453-4057qib7 11184 17 second second JJ cord-005453-4057qib7 11184 18 primary primary JJ cord-005453-4057qib7 11184 19 malignancy malignancy NN cord-005453-4057qib7 11184 20 in in IN cord-005453-4057qib7 11184 21 22 22 CD cord-005453-4057qib7 11184 22 pts pt NNS cord-005453-4057qib7 11184 23 ( ( -LRB- cord-005453-4057qib7 11184 24 6.7 6.7 CD cord-005453-4057qib7 11184 25 % % NN cord-005453-4057qib7 11184 26 ) ) -RRB- cord-005453-4057qib7 11185 1 Treatment treatment NN cord-005453-4057qib7 11185 2 related related JJ cord-005453-4057qib7 11185 3 mortality mortality NN cord-005453-4057qib7 11185 4 was be VBD cord-005453-4057qib7 11185 5 0.8 0.8 CD cord-005453-4057qib7 11185 6 % % NN cord-005453-4057qib7 11185 7 ( ( -LRB- cord-005453-4057qib7 11185 8 8 8 CD cord-005453-4057qib7 11185 9 pts pt NNS cord-005453-4057qib7 11185 10 ) ) -RRB- cord-005453-4057qib7 11185 11 , , , cord-005453-4057qib7 11185 12 and and CC cord-005453-4057qib7 11185 13 mortality mortality NN cord-005453-4057qib7 11185 14 within within IN cord-005453-4057qib7 11185 15 100 100 CD cord-005453-4057qib7 11185 16 days day NNS cord-005453-4057qib7 11185 17 was be VBD cord-005453-4057qib7 11185 18 22 22 CD cord-005453-4057qib7 11185 19 ( ( -LRB- cord-005453-4057qib7 11185 20 2,4 2,4 CD cord-005453-4057qib7 11185 21 % % NN cord-005453-4057qib7 11185 22 ) ) -RRB- cord-005453-4057qib7 11185 23 . . . cord-005453-4057qib7 11186 1 [ [ -LRB- cord-005453-4057qib7 11186 2 [ [ -LRB- cord-005453-4057qib7 11186 3 P494 p494 CD cord-005453-4057qib7 11186 4 Image image NN cord-005453-4057qib7 11186 5 ] ] -RRB- cord-005453-4057qib7 11186 6 1 1 CD cord-005453-4057qib7 11186 7 . . . cord-005453-4057qib7 11187 1 PFS PFS NNP cord-005453-4057qib7 11187 2 and and CC cord-005453-4057qib7 11187 3 OS OS NNP cord-005453-4057qib7 11187 4 in in IN cord-005453-4057qib7 11187 5 patients patient NNS cord-005453-4057qib7 11187 6 underwent undergo VBD cord-005453-4057qib7 11187 7 HDT HDT NNP cord-005453-4057qib7 11187 8 and and CC cord-005453-4057qib7 11187 9 auto auto NN cord-005453-4057qib7 11187 10 - - HYPH cord-005453-4057qib7 11187 11 HCT HCT NNP cord-005453-4057qib7 11187 12 1997 1997 CD cord-005453-4057qib7 11187 13 -2003 -2003 RBR cord-005453-4057qib7 11187 14 , , , cord-005453-4057qib7 11187 15 2004 2004 CD cord-005453-4057qib7 11187 16 -2010 -2010 NN cord-005453-4057qib7 11187 17 , , , cord-005453-4057qib7 11187 18 2011 2011 CD cord-005453-4057qib7 11187 19 -2017 -2017 . cord-005453-4057qib7 11188 1 Conclusions conclusion NNS cord-005453-4057qib7 11188 2 : : : cord-005453-4057qib7 11188 3 More More JJR cord-005453-4057qib7 11188 4 than than IN cord-005453-4057qib7 11188 5 45 45 CD cord-005453-4057qib7 11188 6 % % NN cord-005453-4057qib7 11188 7 of of IN cord-005453-4057qib7 11188 8 patients patient NNS cord-005453-4057qib7 11188 9 who who WP cord-005453-4057qib7 11188 10 underwent undergo VBD cord-005453-4057qib7 11188 11 HDT HDT NNP cord-005453-4057qib7 11188 12 and and CC cord-005453-4057qib7 11188 13 auto auto NN cord-005453-4057qib7 11188 14 - - HYPH cord-005453-4057qib7 11188 15 HCT HCT NNP cord-005453-4057qib7 11188 16 had have VBD cord-005453-4057qib7 11188 17 long long JJ cord-005453-4057qib7 11188 18 term term NN cord-005453-4057qib7 11188 19 survival survival NN cord-005453-4057qib7 11188 20 without without IN cord-005453-4057qib7 11188 21 progressive progressive JJ cord-005453-4057qib7 11188 22 disease disease NN cord-005453-4057qib7 11188 23 . . . cord-005453-4057qib7 11189 1 Older old JJR cord-005453-4057qib7 11189 2 age age NN cord-005453-4057qib7 11189 3 , , , cord-005453-4057qib7 11189 4 non non JJ cord-005453-4057qib7 11189 5 - - JJ cord-005453-4057qib7 11189 6 complete complete JJ cord-005453-4057qib7 11189 7 remission remission NN cord-005453-4057qib7 11189 8 at at IN cord-005453-4057qib7 11189 9 transplant transplant NN cord-005453-4057qib7 11189 10 , , , cord-005453-4057qib7 11189 11 advanced advanced JJ cord-005453-4057qib7 11189 12 stage stage NN cord-005453-4057qib7 11189 13 are be VBP cord-005453-4057qib7 11189 14 associated associate VBN cord-005453-4057qib7 11189 15 with with IN cord-005453-4057qib7 11189 16 poor poor JJ cord-005453-4057qib7 11189 17 outcome outcome NN cord-005453-4057qib7 11189 18 . . . cord-005453-4057qib7 11190 1 Patients patient NNS cord-005453-4057qib7 11190 2 recently recently RB cord-005453-4057qib7 11190 3 transplanted transplant VBN cord-005453-4057qib7 11190 4 had have VBD cord-005453-4057qib7 11190 5 a a DT cord-005453-4057qib7 11190 6 better well JJR cord-005453-4057qib7 11190 7 outcome outcome NN cord-005453-4057qib7 11190 8 than than IN cord-005453-4057qib7 11190 9 patients patient NNS cord-005453-4057qib7 11190 10 transplanted transplant VBN cord-005453-4057qib7 11190 11 before before IN cord-005453-4057qib7 11190 12 2004 2004 CD cord-005453-4057qib7 11190 13 . . . cord-005453-4057qib7 11191 1 Disclosure disclosure NN cord-005453-4057qib7 11191 2 : : : cord-005453-4057qib7 11191 3 Nothing nothing NN cord-005453-4057qib7 11191 4 to to TO cord-005453-4057qib7 11191 5 declare declare VB cord-005453-4057qib7 11191 6 Outcomes outcome NNS cord-005453-4057qib7 11191 7 after after IN cord-005453-4057qib7 11191 8 haploidentical haploidentical JJ cord-005453-4057qib7 11191 9 and and CC cord-005453-4057qib7 11191 10 matched match VBD cord-005453-4057qib7 11191 11 related relate VBN cord-005453-4057qib7 11191 12 HSCT HSCT NNP cord-005453-4057qib7 11191 13 in in IN cord-005453-4057qib7 11191 14 lymphoma lymphoma NN cord-005453-4057qib7 11191 15 do do VBP cord-005453-4057qib7 11191 16 not not RB cord-005453-4057qib7 11191 17 differ differ VB cord-005453-4057qib7 11191 18 significantly significantly RB cord-005453-4057qib7 11191 19 : : : cord-005453-4057qib7 11191 20 A a DT cord-005453-4057qib7 11191 21 single single JJ cord-005453-4057qib7 11191 22 center center NN cord-005453-4057qib7 11191 23 study study NN cord-005453-4057qib7 11191 24 Nadira Nadira NNP cord-005453-4057qib7 11191 25 Durakovic Durakovic NNP cord-005453-4057qib7 11191 26 1,2 1,2 CD cord-005453-4057qib7 11191 27 , , , cord-005453-4057qib7 11191 28 Zinaida Zinaida NNP cord-005453-4057qib7 11191 29 Perić Perić NNP cord-005453-4057qib7 11191 30 1,2 1,2 CD cord-005453-4057qib7 11191 31 , , , cord-005453-4057qib7 11191 32 Lana Lana NNP cord-005453-4057qib7 11191 33 Desnica Desnica NNP cord-005453-4057qib7 11191 34 2 2 CD cord-005453-4057qib7 11191 35 , , , cord-005453-4057qib7 11191 36 Ranka Ranka NNP cord-005453-4057qib7 11191 37 Serventi Serventi NNP cord-005453-4057qib7 11191 38 - - HYPH cord-005453-4057qib7 11191 39 Seiwerth Seiwerth NNP cord-005453-4057qib7 11191 40 2 2 CD cord-005453-4057qib7 11191 41 , , , cord-005453-4057qib7 11191 42 Sandra Sandra NNP cord-005453-4057qib7 11191 43 Bašić Bašić NNP cord-005453-4057qib7 11191 44 Kinda Kinda NNP cord-005453-4057qib7 11191 45 2 2 CD cord-005453-4057qib7 11191 46 , , , cord-005453-4057qib7 11191 47 Ivo Ivo NNP cord-005453-4057qib7 11191 48 Radman Radman NNP cord-005453-4057qib7 11191 49 - - HYPH cord-005453-4057qib7 11191 50 Livaja Livaja NNP cord-005453-4057qib7 11191 51 2 2 CD cord-005453-4057qib7 11191 52 , , , cord-005453-4057qib7 11191 53 Alen Alen NNP cord-005453-4057qib7 11191 54 Ostojić Ostojić NNP cord-005453-4057qib7 11191 55 2 2 CD cord-005453-4057qib7 11191 56 , , , cord-005453-4057qib7 11191 57 Ante Ante NNP cord-005453-4057qib7 11191 58 Vulić Vulić NNP cord-005453-4057qib7 11191 59 2 2 CD cord-005453-4057qib7 11191 60 , , , cord-005453-4057qib7 11191 61 Dražen Dražen NNP cord-005453-4057qib7 11191 62 Pulanić Pulanić NNP cord-005453-4057qib7 11191 63 1,2 1,2 CD cord-005453-4057qib7 11191 64 , , , cord-005453-4057qib7 11191 65 Pavle Pavle NNP cord-005453-4057qib7 11191 66 Rončević Rončević NNP cord-005453-4057qib7 11191 67 2 2 CD cord-005453-4057qib7 11191 68 , , , cord-005453-4057qib7 11191 69 Zorana Zorana NNP cord-005453-4057qib7 11191 70 Grubić Grubić NNP cord-005453-4057qib7 11191 71 2 2 CD cord-005453-4057qib7 11191 72 , , , cord-005453-4057qib7 11191 73 Igor Igor NNP cord-005453-4057qib7 11191 74 Aurer Aurer NNP cord-005453-4057qib7 11191 75 1,2 1,2 CD cord-005453-4057qib7 11191 76 , , , cord-005453-4057qib7 11191 77 Radovan Radovan NNP cord-005453-4057qib7 11191 78 Vrhovac Vrhovac NNP cord-005453-4057qib7 11191 79 1,2 1,2 CD cord-005453-4057qib7 11191 80 1 1 CD cord-005453-4057qib7 11191 81 University University NNP cord-005453-4057qib7 11191 82 of of IN cord-005453-4057qib7 11191 83 Zagreb Zagreb NNP cord-005453-4057qib7 11191 84 , , , cord-005453-4057qib7 11191 85 School School NNP cord-005453-4057qib7 11191 86 of of IN cord-005453-4057qib7 11191 87 Medicine Medicine NNP cord-005453-4057qib7 11191 88 , , , cord-005453-4057qib7 11191 89 Internal Internal NNP cord-005453-4057qib7 11191 90 Medicine Medicine NNP cord-005453-4057qib7 11191 91 , , , cord-005453-4057qib7 11191 92 Zagreb Zagreb NNP cord-005453-4057qib7 11191 93 , , , cord-005453-4057qib7 11191 94 Croatia Croatia NNP cord-005453-4057qib7 11191 95 , , , cord-005453-4057qib7 11191 96 2 2 CD cord-005453-4057qib7 11191 97 UHC UHC NNP cord-005453-4057qib7 11191 98 Zagreb Zagreb NNP cord-005453-4057qib7 11191 99 , , , cord-005453-4057qib7 11191 100 Zagreb Zagreb NNP cord-005453-4057qib7 11191 101 , , , cord-005453-4057qib7 11192 1 Croatia Croatia NNP cord-005453-4057qib7 11192 2 Background Background NNP cord-005453-4057qib7 11192 3 : : : cord-005453-4057qib7 11193 1 Allogeneic Allogeneic NNP cord-005453-4057qib7 11193 2 HSCT HSCT NNP cord-005453-4057qib7 11193 3 still still RB cord-005453-4057qib7 11193 4 offers offer VBZ cord-005453-4057qib7 11193 5 patients patient NNS cord-005453-4057qib7 11193 6 with with IN cord-005453-4057qib7 11193 7 relapsed relapse VBN cord-005453-4057qib7 11193 8 / / SYM cord-005453-4057qib7 11193 9 refractory refractory JJ cord-005453-4057qib7 11193 10 lymphoma lymphoma NN cord-005453-4057qib7 11193 11 the the DT cord-005453-4057qib7 11193 12 best good JJS cord-005453-4057qib7 11193 13 chance chance NN cord-005453-4057qib7 11193 14 of of IN cord-005453-4057qib7 11193 15 long long JJ cord-005453-4057qib7 11193 16 - - HYPH cord-005453-4057qib7 11193 17 term term NN cord-005453-4057qib7 11193 18 survival survival NN cord-005453-4057qib7 11193 19 . . . cord-005453-4057qib7 11194 1 In in IN cord-005453-4057qib7 11194 2 most most RBS cord-005453-4057qib7 11194 3 such such JJ cord-005453-4057qib7 11194 4 patients patient NNS cord-005453-4057qib7 11194 5 timing timing NN cord-005453-4057qib7 11194 6 of of IN cord-005453-4057qib7 11194 7 HSCT HSCT NNP cord-005453-4057qib7 11194 8 is be VBZ cord-005453-4057qib7 11194 9 crucial crucial JJ cord-005453-4057qib7 11194 10 , , , cord-005453-4057qib7 11194 11 therefore therefore RB cord-005453-4057qib7 11194 12 a a DT cord-005453-4057qib7 11194 13 related related JJ cord-005453-4057qib7 11194 14 donor donor NN cord-005453-4057qib7 11194 15 is be VBZ cord-005453-4057qib7 11194 16 preferred prefer VBN cord-005453-4057qib7 11194 17 . . . cord-005453-4057qib7 11195 1 We -PRON- PRP cord-005453-4057qib7 11195 2 analyzed analyze VBD cord-005453-4057qib7 11195 3 acute acute JJ cord-005453-4057qib7 11195 4 and and CC cord-005453-4057qib7 11195 5 chronic chronic JJ cord-005453-4057qib7 11195 6 GVHD GVHD NNP cord-005453-4057qib7 11195 7 incidence incidence NN cord-005453-4057qib7 11195 8 , , , cord-005453-4057qib7 11195 9 relapse relapse NN cord-005453-4057qib7 11195 10 and and CC cord-005453-4057qib7 11195 11 overall overall JJ cord-005453-4057qib7 11195 12 survival survival NN cord-005453-4057qib7 11195 13 , , , cord-005453-4057qib7 11195 14 but but CC cord-005453-4057qib7 11195 15 also also RB cord-005453-4057qib7 11195 16 time time NN cord-005453-4057qib7 11195 17 to to IN cord-005453-4057qib7 11195 18 immunosuppression immunosuppression NN cord-005453-4057qib7 11195 19 ( ( -LRB- cord-005453-4057qib7 11195 20 IS be VBZ cord-005453-4057qib7 11195 21 ) ) -RRB- cord-005453-4057qib7 11195 22 discontinuation discontinuation NN cord-005453-4057qib7 11195 23 and and CC cord-005453-4057qib7 11195 24 hematopoietic hematopoietic JJ cord-005453-4057qib7 11195 25 recovery recovery NN cord-005453-4057qib7 11195 26 comparing compare VBG cord-005453-4057qib7 11195 27 transplantation transplantation NN cord-005453-4057qib7 11195 28 using use VBG cord-005453-4057qib7 11195 29 haploidentical haploidentical JJ cord-005453-4057qib7 11195 30 ( ( -LRB- cord-005453-4057qib7 11195 31 haplo haplo NNP cord-005453-4057qib7 11195 32 ) ) -RRB- cord-005453-4057qib7 11195 33 and and CC cord-005453-4057qib7 11195 34 matched match VBD cord-005453-4057qib7 11195 35 related related JJ cord-005453-4057qib7 11195 36 donors donor NNS cord-005453-4057qib7 11195 37 ( ( -LRB- cord-005453-4057qib7 11195 38 MRD MRD NNP cord-005453-4057qib7 11195 39 ) ) -RRB- cord-005453-4057qib7 11195 40 in in IN cord-005453-4057qib7 11195 41 single single JJ cord-005453-4057qib7 11195 42 center center NN cord-005453-4057qib7 11195 43 in in IN cord-005453-4057qib7 11195 44 this this DT cord-005453-4057qib7 11195 45 indication indication NN cord-005453-4057qib7 11195 46 . . . cord-005453-4057qib7 11196 1 Methods method NNS cord-005453-4057qib7 11196 2 : : : cord-005453-4057qib7 11196 3 In in IN cord-005453-4057qib7 11196 4 the the DT cord-005453-4057qib7 11196 5 time time NN cord-005453-4057qib7 11196 6 period period NN cord-005453-4057qib7 11196 7 between between IN cord-005453-4057qib7 11196 8 5/2011 5/2011 CD cord-005453-4057qib7 11196 9 and and CC cord-005453-4057qib7 11196 10 5/2018 5/2018 CD cord-005453-4057qib7 11196 11 at at IN cord-005453-4057qib7 11196 12 UHC UHC NNP cord-005453-4057qib7 11196 13 Zagreb Zagreb NNP cord-005453-4057qib7 11196 14 , , , cord-005453-4057qib7 11196 15 Croatia Croatia NNP cord-005453-4057qib7 11196 16 , , , cord-005453-4057qib7 11196 17 10 10 CD cord-005453-4057qib7 11196 18 MRD MRD NNP cord-005453-4057qib7 11196 19 and and CC cord-005453-4057qib7 11196 20 13 13 CD cord-005453-4057qib7 11196 21 haplo haplo NN cord-005453-4057qib7 11196 22 transplantations transplantation NNS cord-005453-4057qib7 11196 23 in in IN cord-005453-4057qib7 11196 24 lymphoma lymphoma NN cord-005453-4057qib7 11196 25 were be VBD cord-005453-4057qib7 11196 26 done do VBN cord-005453-4057qib7 11196 27 , , , cord-005453-4057qib7 11196 28 15 15 CD cord-005453-4057qib7 11196 29 for for IN cord-005453-4057qib7 11196 30 Hodgkin Hodgkin NNP cord-005453-4057qib7 11196 31 and and CC cord-005453-4057qib7 11196 32 8 8 CD cord-005453-4057qib7 11196 33 for for IN cord-005453-4057qib7 11196 34 NHL NHL NNP cord-005453-4057qib7 11196 35 . . . cord-005453-4057qib7 11197 1 All all DT cord-005453-4057qib7 11197 2 patients patient NNS cord-005453-4057qib7 11197 3 transplanted transplant VBN cord-005453-4057qib7 11197 4 from from IN cord-005453-4057qib7 11197 5 haploidentical haploidentical JJ cord-005453-4057qib7 11197 6 donors donor NNS cord-005453-4057qib7 11197 7 received receive VBD cord-005453-4057qib7 11197 8 PTCY PTCY NNP cord-005453-4057qib7 11197 9 . . . cord-005453-4057qib7 11198 1 Data datum NNS cord-005453-4057qib7 11198 2 were be VBD cord-005453-4057qib7 11198 3 computed compute VBN cord-005453-4057qib7 11198 4 using use VBG cord-005453-4057qib7 11198 5 the the DT cord-005453-4057qib7 11198 6 R r NN cord-005453-4057qib7 11198 7 package package NN cord-005453-4057qib7 11198 8 . . . cord-005453-4057qib7 11199 1 The the DT cord-005453-4057qib7 11199 2 probability probability NN cord-005453-4057qib7 11199 3 of of IN cord-005453-4057qib7 11199 4 GVHD GVHD NNP cord-005453-4057qib7 11199 5 was be VBD cord-005453-4057qib7 11199 6 calculated calculate VBN cord-005453-4057qib7 11199 7 using use VBG cord-005453-4057qib7 11199 8 the the DT cord-005453-4057qib7 11199 9 cumulative cumulative JJ cord-005453-4057qib7 11199 10 incidence incidence NN cord-005453-4057qib7 11199 11 method method NN cord-005453-4057qib7 11199 12 and and CC cord-005453-4057qib7 11199 13 subgroups subgroup NNS cord-005453-4057qib7 11199 14 were be VBD cord-005453-4057qib7 11199 15 compared compare VBN cord-005453-4057qib7 11199 16 using use VBG cord-005453-4057qib7 11199 17 the the DT cord-005453-4057qib7 11199 18 Gray gray JJ cord-005453-4057qib7 11199 19 test test NN cord-005453-4057qib7 11199 20 . . . cord-005453-4057qib7 11200 1 Results result NNS cord-005453-4057qib7 11200 2 : : : cord-005453-4057qib7 11201 1 Median median JJ cord-005453-4057qib7 11201 2 age age NN cord-005453-4057qib7 11201 3 was be VBD cord-005453-4057qib7 11201 4 38 38 CD cord-005453-4057qib7 11201 5 ( ( -LRB- cord-005453-4057qib7 11201 6 19 19 CD cord-005453-4057qib7 11201 7 - - SYM cord-005453-4057qib7 11201 8 62 62 CD cord-005453-4057qib7 11201 9 ) ) -RRB- cord-005453-4057qib7 11201 10 years year NNS cord-005453-4057qib7 11201 11 ; ; : cord-005453-4057qib7 11201 12 36 36 CD cord-005453-4057qib7 11201 13 ( ( -LRB- cord-005453-4057qib7 11201 14 19 19 CD cord-005453-4057qib7 11201 15 - - SYM cord-005453-4057qib7 11201 16 62 62 CD cord-005453-4057qib7 11201 17 ) ) -RRB- cord-005453-4057qib7 11201 18 in in IN cord-005453-4057qib7 11201 19 haplo haplo NNP cord-005453-4057qib7 11201 20 and and CC cord-005453-4057qib7 11201 21 41 41 CD cord-005453-4057qib7 11201 22 ( ( -LRB- cord-005453-4057qib7 11201 23 25 25 CD cord-005453-4057qib7 11201 24 - - SYM cord-005453-4057qib7 11201 25 56 56 CD cord-005453-4057qib7 11201 26 ) ) -RRB- cord-005453-4057qib7 11201 27 in in IN cord-005453-4057qib7 11201 28 MRD MRD NNP cord-005453-4057qib7 11201 29 group group NN cord-005453-4057qib7 11201 30 . . . cord-005453-4057qib7 11202 1 Four four CD cord-005453-4057qib7 11202 2 patients patient NNS cord-005453-4057qib7 11202 3 were be VBD cord-005453-4057qib7 11202 4 in in IN cord-005453-4057qib7 11202 5 PR PR NNP cord-005453-4057qib7 11202 6 and and CC cord-005453-4057qib7 11202 7 9 9 CD cord-005453-4057qib7 11202 8 in in IN cord-005453-4057qib7 11202 9 CR CR NNP cord-005453-4057qib7 11202 10 in in IN cord-005453-4057qib7 11202 11 haplo haplo NNP cord-005453-4057qib7 11202 12 group group NN cord-005453-4057qib7 11202 13 , , , cord-005453-4057qib7 11202 14 while while IN cord-005453-4057qib7 11202 15 in in IN cord-005453-4057qib7 11202 16 MRD MRD NNP cord-005453-4057qib7 11202 17 group group NN cord-005453-4057qib7 11202 18 5 5 CD cord-005453-4057qib7 11202 19 patients patient NNS cord-005453-4057qib7 11202 20 were be VBD cord-005453-4057qib7 11202 21 in in IN cord-005453-4057qib7 11202 22 CR CR NNP cord-005453-4057qib7 11202 23 and and CC cord-005453-4057qib7 11202 24 5 5 CD cord-005453-4057qib7 11202 25 in in IN cord-005453-4057qib7 11202 26 PR PR NNP cord-005453-4057qib7 11202 27 . . . cord-005453-4057qib7 11203 1 In in IN cord-005453-4057qib7 11203 2 haplo haplo NNP cord-005453-4057qib7 11203 3 group group NN cord-005453-4057qib7 11203 4 12 12 CD cord-005453-4057qib7 11203 5 patients patient NNS cord-005453-4057qib7 11203 6 ( ( -LRB- cord-005453-4057qib7 11203 7 92 92 CD cord-005453-4057qib7 11203 8 % % NN cord-005453-4057qib7 11203 9 ) ) -RRB- cord-005453-4057qib7 11203 10 received receive VBD cord-005453-4057qib7 11203 11 bone bone NN cord-005453-4057qib7 11203 12 marrow marrow NN cord-005453-4057qib7 11203 13 ( ( -LRB- cord-005453-4057qib7 11203 14 BM BM NNP cord-005453-4057qib7 11203 15 ) ) -RRB- cord-005453-4057qib7 11203 16 and and CC cord-005453-4057qib7 11203 17 only only RB cord-005453-4057qib7 11203 18 1 1 CD cord-005453-4057qib7 11203 19 ( ( -LRB- cord-005453-4057qib7 11203 20 8 8 CD cord-005453-4057qib7 11203 21 % % NN cord-005453-4057qib7 11203 22 ) ) -RRB- cord-005453-4057qib7 11203 23 peripheral peripheral JJ cord-005453-4057qib7 11203 24 blood blood NN cord-005453-4057qib7 11203 25 stem stem NN cord-005453-4057qib7 11203 26 cells cell NNS cord-005453-4057qib7 11203 27 ( ( -LRB- cord-005453-4057qib7 11203 28 PBSC PBSC NNP cord-005453-4057qib7 11203 29 ) ) -RRB- cord-005453-4057qib7 11203 30 . . . cord-005453-4057qib7 11204 1 In in IN cord-005453-4057qib7 11204 2 MRD MRD NNP cord-005453-4057qib7 11204 3 group group NN cord-005453-4057qib7 11204 4 all all DT cord-005453-4057qib7 11204 5 patients patient NNS cord-005453-4057qib7 11204 6 received receive VBD cord-005453-4057qib7 11204 7 PBSC PBSC NNP cord-005453-4057qib7 11204 8 . . . cord-005453-4057qib7 11205 1 All all DT cord-005453-4057qib7 11205 2 patients patient NNS cord-005453-4057qib7 11205 3 in in IN cord-005453-4057qib7 11205 4 haplo haplo NNP cord-005453-4057qib7 11205 5 group group NN cord-005453-4057qib7 11205 6 received receive VBD cord-005453-4057qib7 11205 7 NMA NMA NNP cord-005453-4057qib7 11205 8 ( ( -LRB- cord-005453-4057qib7 11205 9 " " `` cord-005453-4057qib7 11205 10 Baltimore Baltimore NNP cord-005453-4057qib7 11205 11 " " '' cord-005453-4057qib7 11205 12 ) ) -RRB- cord-005453-4057qib7 11206 1 conditioning conditioning NN cord-005453-4057qib7 11206 2 with with IN cord-005453-4057qib7 11206 3 PTCY PTCY NNP cord-005453-4057qib7 11206 4 while while IN cord-005453-4057qib7 11206 5 in in IN cord-005453-4057qib7 11206 6 MRD MRD NNP cord-005453-4057qib7 11206 7 group group NN cord-005453-4057qib7 11206 8 9 9 CD cord-005453-4057qib7 11206 9 patients patient NNS cord-005453-4057qib7 11206 10 ( ( -LRB- cord-005453-4057qib7 11206 11 90 90 CD cord-005453-4057qib7 11206 12 % % NN cord-005453-4057qib7 11206 13 ) ) -RRB- cord-005453-4057qib7 11206 14 received receive VBD cord-005453-4057qib7 11206 15 Flu Flu NNP cord-005453-4057qib7 11206 16 - - HYPH cord-005453-4057qib7 11206 17 Bu2ATG Bu2ATG NNP cord-005453-4057qib7 11206 18 , , , cord-005453-4057qib7 11206 19 and and CC cord-005453-4057qib7 11206 20 only only RB cord-005453-4057qib7 11206 21 one one CD cord-005453-4057qib7 11206 22 received receive VBN cord-005453-4057qib7 11206 23 FluTBI flutbi NN cord-005453-4057qib7 11206 24 as as IN cord-005453-4057qib7 11206 25 conditioning conditioning NN cord-005453-4057qib7 11206 26 protocol protocol NN cord-005453-4057qib7 11206 27 . . . cord-005453-4057qib7 11207 1 In in IN cord-005453-4057qib7 11207 2 haplo haplo NN cord-005453-4057qib7 11207 3 group group NN cord-005453-4057qib7 11207 4 85 85 CD cord-005453-4057qib7 11207 5 % % NN cord-005453-4057qib7 11207 6 patients patient NNS cord-005453-4057qib7 11207 7 were be VBD cord-005453-4057qib7 11207 8 previously previously RB cord-005453-4057qib7 11207 9 treated treat VBN cord-005453-4057qib7 11207 10 with with IN cord-005453-4057qib7 11207 11 autologus autologus JJ cord-005453-4057qib7 11207 12 transplantation transplantation NN cord-005453-4057qib7 11207 13 , , , cord-005453-4057qib7 11207 14 80 80 CD cord-005453-4057qib7 11207 15 % % NN cord-005453-4057qib7 11207 16 in in IN cord-005453-4057qib7 11207 17 MRD MRD NNP cord-005453-4057qib7 11207 18 group group NN cord-005453-4057qib7 11207 19 . . . cord-005453-4057qib7 11208 1 There there EX cord-005453-4057qib7 11208 2 was be VBD cord-005453-4057qib7 11208 3 no no DT cord-005453-4057qib7 11208 4 significant significant JJ cord-005453-4057qib7 11208 5 difference difference NN cord-005453-4057qib7 11208 6 in in IN cord-005453-4057qib7 11208 7 time time NN cord-005453-4057qib7 11208 8 to to IN cord-005453-4057qib7 11208 9 IS be VBZ cord-005453-4057qib7 11208 10 discontinuation discontinuation NN cord-005453-4057qib7 11208 11 , , , cord-005453-4057qib7 11208 12 149 149 CD cord-005453-4057qib7 11208 13 and and CC cord-005453-4057qib7 11208 14 155 155 CD cord-005453-4057qib7 11208 15 days day NNS cord-005453-4057qib7 11208 16 in in IN cord-005453-4057qib7 11208 17 haplo haplo NNP cord-005453-4057qib7 11208 18 and and CC cord-005453-4057qib7 11208 19 MRD MRD NNP cord-005453-4057qib7 11208 20 group group NN cord-005453-4057qib7 11208 21 , , , cord-005453-4057qib7 11208 22 respectively respectively RB cord-005453-4057qib7 11208 23 . . . cord-005453-4057qib7 11209 1 Patients patient NNS cord-005453-4057qib7 11209 2 after after IN cord-005453-4057qib7 11209 3 haplo haplo NNP cord-005453-4057qib7 11209 4 recovered recover VBD cord-005453-4057qib7 11209 5 slower slow RBR cord-005453-4057qib7 11209 6 , , , cord-005453-4057qib7 11209 7 recovering recover VBG cord-005453-4057qib7 11209 8 ANC ANC NNP cord-005453-4057qib7 11209 9 after after IN cord-005453-4057qib7 11209 10 22.6 22.6 CD cord-005453-4057qib7 11209 11 days day NNS cord-005453-4057qib7 11209 12 ( ( -LRB- cord-005453-4057qib7 11209 13 95 95 CD cord-005453-4057qib7 11209 14 % % NN cord-005453-4057qib7 11209 15 CI CI NNP cord-005453-4057qib7 11209 16 , , , cord-005453-4057qib7 11209 17 17.7 17.7 CD cord-005453-4057qib7 11209 18 - - HYPH cord-005453-4057qib7 11209 19 27.4 27.4 CD cord-005453-4057qib7 11209 20 ) ) -RRB- cord-005453-4057qib7 11209 21 and and CC cord-005453-4057qib7 11209 22 16.5 16.5 CD cord-005453-4057qib7 11209 23 ( ( -LRB- cord-005453-4057qib7 11209 24 95 95 CD cord-005453-4057qib7 11209 25 % % NN cord-005453-4057qib7 11209 26 CI CI NNP cord-005453-4057qib7 11209 27 , , , cord-005453-4057qib7 11209 28 13.9 13.9 CD cord-005453-4057qib7 11209 29 - - SYM cord-005453-4057qib7 11209 30 19 19 CD cord-005453-4057qib7 11209 31 ) ) -RRB- cord-005453-4057qib7 11209 32 ( ( -LRB- cord-005453-4057qib7 11209 33 p=0.04 p=0.04 NN cord-005453-4057qib7 11209 34 ) ) -RRB- cord-005453-4057qib7 11209 35 and and CC cord-005453-4057qib7 11209 36 recovering recover VBG cord-005453-4057qib7 11209 37 platelets platelet NNS cord-005453-4057qib7 11209 38 after after IN cord-005453-4057qib7 11209 39 34.6 34.6 CD cord-005453-4057qib7 11209 40 days day NNS cord-005453-4057qib7 11209 41 ( ( -LRB- cord-005453-4057qib7 11209 42 95 95 CD cord-005453-4057qib7 11209 43 % % NN cord-005453-4057qib7 11209 44 CI CI NNP cord-005453-4057qib7 11209 45 , , , cord-005453-4057qib7 11209 46 15.5 15.5 CD cord-005453-4057qib7 11209 47 - - SYM cord-005453-4057qib7 11209 48 53.7 53.7 CD cord-005453-4057qib7 11209 49 ) ) -RRB- cord-005453-4057qib7 11209 50 and and CC cord-005453-4057qib7 11209 51 10.8 10.8 CD cord-005453-4057qib7 11209 52 ( ( -LRB- cord-005453-4057qib7 11209 53 95 95 CD cord-005453-4057qib7 11209 54 % % NN cord-005453-4057qib7 11209 55 CI ci NN cord-005453-4057qib7 11209 56 , , , cord-005453-4057qib7 11209 57 9.2 9.2 CD cord-005453-4057qib7 11209 58 - - HYPH cord-005453-4057qib7 11209 59 12.4 12.4 CD cord-005453-4057qib7 11209 60 ) ) -RRB- cord-005453-4057qib7 11209 61 ( ( -LRB- cord-005453-4057qib7 11209 62 p p NN cord-005453-4057qib7 11209 63 < < XX cord-005453-4057qib7 11209 64 0.01 0.01 CD cord-005453-4057qib7 11209 65 ) ) -RRB- cord-005453-4057qib7 11209 66 in in IN cord-005453-4057qib7 11209 67 haplo haplo NNP cord-005453-4057qib7 11209 68 and and CC cord-005453-4057qib7 11209 69 MRD MRD NNP cord-005453-4057qib7 11209 70 group group NN cord-005453-4057qib7 11209 71 . . . cord-005453-4057qib7 11210 1 With with IN cord-005453-4057qib7 11210 2 a a DT cord-005453-4057qib7 11210 3 median median NN cord-005453-4057qib7 11210 4 follow follow NN cord-005453-4057qib7 11210 5 up up IN cord-005453-4057qib7 11210 6 of of IN cord-005453-4057qib7 11210 7 469 469 CD cord-005453-4057qib7 11210 8 days day NNS cord-005453-4057qib7 11210 9 , , , cord-005453-4057qib7 11210 10 overall overall JJ cord-005453-4057qib7 11210 11 survival survival NN cord-005453-4057qib7 11210 12 was be VBD cord-005453-4057qib7 11210 13 83 83 CD cord-005453-4057qib7 11210 14 % % NN cord-005453-4057qib7 11210 15 ( ( -LRB- cord-005453-4057qib7 11210 16 95 95 CD cord-005453-4057qib7 11210 17 % % NN cord-005453-4057qib7 11210 18 CI CI NNP cord-005453-4057qib7 11210 19 , , , cord-005453-4057qib7 11210 20 63 63 CD cord-005453-4057qib7 11210 21 - - SYM cord-005453-4057qib7 11210 22 100 100 CD cord-005453-4057qib7 11210 23 ) ) -RRB- cord-005453-4057qib7 11210 24 in in IN cord-005453-4057qib7 11210 25 haplo haplo NNP cord-005453-4057qib7 11210 26 and and CC cord-005453-4057qib7 11210 27 80 80 CD cord-005453-4057qib7 11210 28 % % NN cord-005453-4057qib7 11210 29 ( ( -LRB- cord-005453-4057qib7 11210 30 95 95 CD cord-005453-4057qib7 11210 31 % % NN cord-005453-4057qib7 11210 32 CI CI NNP cord-005453-4057qib7 11210 33 , , , cord-005453-4057qib7 11210 34 59 59 CD cord-005453-4057qib7 11210 35 - - SYM cord-005453-4057qib7 11210 36 100 100 CD cord-005453-4057qib7 11210 37 ) ) -RRB- cord-005453-4057qib7 11210 38 in in IN cord-005453-4057qib7 11210 39 MRD MRD NNP cord-005453-4057qib7 11210 40 group group NN cord-005453-4057qib7 11210 41 . . . cord-005453-4057qib7 11211 1 TRM TRM NNP cord-005453-4057qib7 11211 2 was be VBD cord-005453-4057qib7 11211 3 8 8 CD cord-005453-4057qib7 11211 4 % % NN cord-005453-4057qib7 11211 5 in in IN cord-005453-4057qib7 11211 6 haplo haplo NN cord-005453-4057qib7 11211 7 and and CC cord-005453-4057qib7 11211 8 20 20 CD cord-005453-4057qib7 11211 9 % % NN cord-005453-4057qib7 11211 10 in in IN cord-005453-4057qib7 11211 11 MRD MRD NNP cord-005453-4057qib7 11211 12 group group NN cord-005453-4057qib7 11211 13 . . . cord-005453-4057qib7 11212 1 Cumulative cumulative JJ cord-005453-4057qib7 11212 2 incidence incidence NN cord-005453-4057qib7 11212 3 of of IN cord-005453-4057qib7 11212 4 aGVHD aGVHD NNP cord-005453-4057qib7 11212 5 II II NNP cord-005453-4057qib7 11212 6 - - HYPH cord-005453-4057qib7 11212 7 IV IV NNP cord-005453-4057qib7 11212 8 was be VBD cord-005453-4057qib7 11212 9 31 31 CD cord-005453-4057qib7 11212 10 % % NN cord-005453-4057qib7 11212 11 ( ( -LRB- cord-005453-4057qib7 11212 12 95 95 CD cord-005453-4057qib7 11212 13 % % NN cord-005453-4057qib7 11212 14 CI ci NN cord-005453-4057qib7 11212 15 , , , cord-005453-4057qib7 11212 16 9 9 CD cord-005453-4057qib7 11212 17 - - SYM cord-005453-4057qib7 11212 18 56 56 CD cord-005453-4057qib7 11212 19 ) ) -RRB- cord-005453-4057qib7 11212 20 and and CC cord-005453-4057qib7 11212 21 32 32 CD cord-005453-4057qib7 11212 22 % % NN cord-005453-4057qib7 11212 23 ( ( -LRB- cord-005453-4057qib7 11212 24 95 95 CD cord-005453-4057qib7 11212 25 % % NN cord-005453-4057qib7 11212 26 CI CI NNP cord-005453-4057qib7 11212 27 , , , cord-005453-4057qib7 11212 28 in in IN cord-005453-4057qib7 11212 29 haplo haplo NNP cord-005453-4057qib7 11212 30 and and CC cord-005453-4057qib7 11212 31 MRD MRD NNP cord-005453-4057qib7 11212 32 group group NN cord-005453-4057qib7 11212 33 , , , cord-005453-4057qib7 11212 34 respectively respectively RB cord-005453-4057qib7 11212 35 ( ( -LRB- cord-005453-4057qib7 11212 36 p=0.84 p=0.84 NNP cord-005453-4057qib7 11212 37 ) ) -RRB- cord-005453-4057qib7 11212 38 . . . cord-005453-4057qib7 11213 1 Cumulative cumulative JJ cord-005453-4057qib7 11213 2 incidence incidence NN cord-005453-4057qib7 11213 3 of of IN cord-005453-4057qib7 11213 4 cGVHD cGVHD NNP cord-005453-4057qib7 11213 5 requiring require VBG cord-005453-4057qib7 11213 6 treatment treatment NN cord-005453-4057qib7 11213 7 was be VBD cord-005453-4057qib7 11213 8 22 22 CD cord-005453-4057qib7 11213 9 % % NN cord-005453-4057qib7 11213 10 ( ( -LRB- cord-005453-4057qib7 11213 11 95 95 CD cord-005453-4057qib7 11213 12 % % NN cord-005453-4057qib7 11213 13 CI CI NNP cord-005453-4057qib7 11213 14 , , , cord-005453-4057qib7 11213 15 and and CC cord-005453-4057qib7 11213 16 MRD MRD NNP cord-005453-4057qib7 11213 17 20 20 CD cord-005453-4057qib7 11213 18 % % NN cord-005453-4057qib7 11213 19 ( ( -LRB- cord-005453-4057qib7 11213 20 95 95 CD cord-005453-4057qib7 11213 21 % % NN cord-005453-4057qib7 11213 22 CI ci NN cord-005453-4057qib7 11213 23 , , , cord-005453-4057qib7 11213 24 0 0 CD cord-005453-4057qib7 11213 25 - - SYM cord-005453-4057qib7 11213 26 62 62 CD cord-005453-4057qib7 11213 27 ) ) -RRB- cord-005453-4057qib7 11213 28 in in IN cord-005453-4057qib7 11213 29 haplo haplo NNP cord-005453-4057qib7 11213 30 and and CC cord-005453-4057qib7 11213 31 MRD MRD NNP cord-005453-4057qib7 11213 32 group group NN cord-005453-4057qib7 11213 33 , , , cord-005453-4057qib7 11213 34 respectively respectively RB cord-005453-4057qib7 11213 35 ( ( -LRB- cord-005453-4057qib7 11213 36 p=0.46 p=0.46 NNP cord-005453-4057qib7 11213 37 ) ) -RRB- cord-005453-4057qib7 11213 38 . . . cord-005453-4057qib7 11214 1 All all DT cord-005453-4057qib7 11214 2 cases case NNS cord-005453-4057qib7 11214 3 of of IN cord-005453-4057qib7 11214 4 cGVHD cGVHD NNP cord-005453-4057qib7 11214 5 developed develop VBN cord-005453-4057qib7 11214 6 after after IN cord-005453-4057qib7 11214 7 DLI DLI NNP cord-005453-4057qib7 11214 8 . . . cord-005453-4057qib7 11215 1 Cumulative cumulative JJ cord-005453-4057qib7 11215 2 incidence incidence NN cord-005453-4057qib7 11215 3 of of IN cord-005453-4057qib7 11215 4 relapse relapse NN cord-005453-4057qib7 11215 5 was be VBD cord-005453-4057qib7 11215 6 32 32 CD cord-005453-4057qib7 11215 7 % % NN cord-005453-4057qib7 11215 8 ( ( -LRB- cord-005453-4057qib7 11215 9 95 95 CD cord-005453-4057qib7 11215 10 % % NN cord-005453-4057qib7 11215 11 CI ci NN cord-005453-4057qib7 11215 12 , , , cord-005453-4057qib7 11215 13 9 9 CD cord-005453-4057qib7 11215 14 - - SYM cord-005453-4057qib7 11215 15 58 58 CD cord-005453-4057qib7 11215 16 ) ) -RRB- cord-005453-4057qib7 11215 17 and and CC cord-005453-4057qib7 11215 18 38 38 CD cord-005453-4057qib7 11215 19 % % NN cord-005453-4057qib7 11215 20 ( ( -LRB- cord-005453-4057qib7 11215 21 95 95 CD cord-005453-4057qib7 11215 22 % % NN cord-005453-4057qib7 11215 23 CI CI NNP cord-005453-4057qib7 11215 24 , , , cord-005453-4057qib7 11215 25 7 7 CD cord-005453-4057qib7 11215 26 - - SYM cord-005453-4057qib7 11215 27 72 72 CD cord-005453-4057qib7 11215 28 ) ) -RRB- cord-005453-4057qib7 11215 29 for for IN cord-005453-4057qib7 11215 30 haplo haplo NNP cord-005453-4057qib7 11215 31 and and CC cord-005453-4057qib7 11215 32 MRD MRD NNP cord-005453-4057qib7 11215 33 group group NN cord-005453-4057qib7 11215 34 , , , cord-005453-4057qib7 11215 35 respectively respectively RB cord-005453-4057qib7 11215 36 ( ( -LRB- cord-005453-4057qib7 11215 37 p=0.77 p=0.77 NNP cord-005453-4057qib7 11215 38 ) ) -RRB- cord-005453-4057qib7 11215 39 . . . cord-005453-4057qib7 11216 1 Conclusions conclusion NNS cord-005453-4057qib7 11216 2 : : : cord-005453-4057qib7 11217 1 We -PRON- PRP cord-005453-4057qib7 11217 2 found find VBD cord-005453-4057qib7 11217 3 no no DT cord-005453-4057qib7 11217 4 significant significant JJ cord-005453-4057qib7 11217 5 difference difference NN cord-005453-4057qib7 11217 6 in in IN cord-005453-4057qib7 11217 7 overall overall JJ cord-005453-4057qib7 11217 8 survival survival NN cord-005453-4057qib7 11217 9 , , , cord-005453-4057qib7 11217 10 relapse relapse NN cord-005453-4057qib7 11217 11 incidence incidence NN cord-005453-4057qib7 11217 12 , , , cord-005453-4057qib7 11217 13 aGVHD aGVHD NNP cord-005453-4057qib7 11217 14 and and CC cord-005453-4057qib7 11217 15 cGVHD cGVHD NNP cord-005453-4057qib7 11217 16 incidence incidence NN cord-005453-4057qib7 11217 17 between between IN cord-005453-4057qib7 11217 18 these these DT cord-005453-4057qib7 11217 19 two two CD cord-005453-4057qib7 11217 20 groups group NNS cord-005453-4057qib7 11217 21 . . . cord-005453-4057qib7 11218 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 11218 2 recovery recovery NN cord-005453-4057qib7 11218 3 was be VBD cord-005453-4057qib7 11218 4 slower slow JJR cord-005453-4057qib7 11218 5 after after IN cord-005453-4057qib7 11218 6 haploidentical haploidentical JJ cord-005453-4057qib7 11218 7 transplantation transplantation NN cord-005453-4057qib7 11218 8 , , , cord-005453-4057qib7 11218 9 but but CC cord-005453-4057qib7 11218 10 it -PRON- PRP cord-005453-4057qib7 11218 11 did do VBD cord-005453-4057qib7 11218 12 not not RB cord-005453-4057qib7 11218 13 influence influence VB cord-005453-4057qib7 11218 14 TRM TRM NNP cord-005453-4057qib7 11218 15 as as IN cord-005453-4057qib7 11218 16 it -PRON- PRP cord-005453-4057qib7 11218 17 was be VBD cord-005453-4057qib7 11218 18 higher high JJR cord-005453-4057qib7 11218 19 after after IN cord-005453-4057qib7 11218 20 MRD MRD NNP cord-005453-4057qib7 11218 21 . . . cord-005453-4057qib7 11219 1 Even even RB cord-005453-4057qib7 11219 2 though though IN cord-005453-4057qib7 11219 3 limited limit VBN cord-005453-4057qib7 11219 4 in in IN cord-005453-4057qib7 11219 5 number number NN cord-005453-4057qib7 11219 6 , , , cord-005453-4057qib7 11219 7 this this DT cord-005453-4057qib7 11219 8 data datum NNS cord-005453-4057qib7 11219 9 contribute contribute VBP cord-005453-4057qib7 11219 10 to to IN cord-005453-4057qib7 11219 11 the the DT cord-005453-4057qib7 11219 12 growing grow VBG cord-005453-4057qib7 11219 13 body body NN cord-005453-4057qib7 11219 14 of of IN cord-005453-4057qib7 11219 15 evidence evidence NN cord-005453-4057qib7 11219 16 that that IN cord-005453-4057qib7 11219 17 use use NN cord-005453-4057qib7 11219 18 of of IN cord-005453-4057qib7 11219 19 haploidentical haploidentical JJ cord-005453-4057qib7 11219 20 donors donor NNS cord-005453-4057qib7 11219 21 , , , cord-005453-4057qib7 11219 22 particularly particularly RB cord-005453-4057qib7 11219 23 in in IN cord-005453-4057qib7 11219 24 lymphoma lymphoma NN cord-005453-4057qib7 11219 25 setting setting NN cord-005453-4057qib7 11219 26 , , , cord-005453-4057qib7 11219 27 is be VBZ cord-005453-4057qib7 11219 28 as as RB cord-005453-4057qib7 11219 29 worthy worthy JJ cord-005453-4057qib7 11219 30 as as IN cord-005453-4057qib7 11219 31 using use VBG cord-005453-4057qib7 11219 32 matched match VBN cord-005453-4057qib7 11219 33 related related JJ cord-005453-4057qib7 11219 34 donors donor NNS cord-005453-4057qib7 11219 35 and and CC cord-005453-4057qib7 11219 36 should should MD cord-005453-4057qib7 11219 37 be be VB cord-005453-4057qib7 11219 38 at at IN cord-005453-4057qib7 11219 39 least least JJS cord-005453-4057qib7 11219 40 second second JJ cord-005453-4057qib7 11219 41 choice choice NN cord-005453-4057qib7 11219 42 in in IN cord-005453-4057qib7 11219 43 donor donor NN cord-005453-4057qib7 11219 44 selection selection NN cord-005453-4057qib7 11219 45 , , , cord-005453-4057qib7 11219 46 and and CC cord-005453-4057qib7 11219 47 in in IN cord-005453-4057qib7 11219 48 older old JJR cord-005453-4057qib7 11219 49 patients patient NNS cord-005453-4057qib7 11219 50 ( ( -LRB- cord-005453-4057qib7 11219 51 with with IN cord-005453-4057qib7 11219 52 older old JJR cord-005453-4057qib7 11219 53 donors donor NNS cord-005453-4057qib7 11219 54 ) ) -RRB- cord-005453-4057qib7 11219 55 probably probably RB cord-005453-4057qib7 11219 56 the the DT cord-005453-4057qib7 11219 57 first first JJ cord-005453-4057qib7 11219 58 one one CD cord-005453-4057qib7 11219 59 . . . cord-005453-4057qib7 11220 1 Disclosure disclosure NN cord-005453-4057qib7 11220 2 : : : cord-005453-4057qib7 11220 3 Nothing nothing NN cord-005453-4057qib7 11220 4 to to TO cord-005453-4057qib7 11220 5 declare declare VB cord-005453-4057qib7 11220 6 . . . cord-005453-4057qib7 11221 1 Adjuvant adjuvant NN cord-005453-4057qib7 11221 2 involved involve VBN cord-005453-4057qib7 11221 3 field field NN cord-005453-4057qib7 11221 4 radiotherapy radiotherapy NN cord-005453-4057qib7 11221 5 post post JJ cord-005453-4057qib7 11221 6 autologous autologous JJ cord-005453-4057qib7 11221 7 stem stem NN cord-005453-4057qib7 11221 8 cell cell NN cord-005453-4057qib7 11221 9 transplantation transplantation NN cord-005453-4057qib7 11221 10 for for IN cord-005453-4057qib7 11221 11 refractory refractory JJ cord-005453-4057qib7 11221 12 / / SYM cord-005453-4057qib7 11221 13 relapsed relapse VBN cord-005453-4057qib7 11221 14 lymphomas lymphoma NNS cord-005453-4057qib7 11222 1 results result NNS cord-005453-4057qib7 11222 2 in in IN cord-005453-4057qib7 11222 3 favorable favorable JJ cord-005453-4057qib7 11222 4 outcome outcome NN cord-005453-4057qib7 11222 5 with with IN cord-005453-4057qib7 11222 6 low low JJ cord-005453-4057qib7 11222 7 toxicity toxicity NN cord-005453-4057qib7 11222 8 : : : cord-005453-4057qib7 11222 9 A a DT cord-005453-4057qib7 11222 10 single single JJ cord-005453-4057qib7 11222 11 center center NN cord-005453-4057qib7 11222 12 experience experience NN cord-005453-4057qib7 11223 1 Background background NN cord-005453-4057qib7 11223 2 : : : cord-005453-4057qib7 11224 1 Involved involve VBN cord-005453-4057qib7 11224 2 field field NN cord-005453-4057qib7 11224 3 radiotherapy radiotherapy NN cord-005453-4057qib7 11224 4 ( ( -LRB- cord-005453-4057qib7 11224 5 IFRT IFRT NNP cord-005453-4057qib7 11224 6 ) ) -RRB- cord-005453-4057qib7 11224 7 to to IN cord-005453-4057qib7 11224 8 previous previous JJ cord-005453-4057qib7 11224 9 bulky bulky JJ cord-005453-4057qib7 11224 10 or or CC cord-005453-4057qib7 11224 11 localized localized JJ cord-005453-4057qib7 11224 12 residual residual JJ cord-005453-4057qib7 11224 13 disease disease NN cord-005453-4057qib7 11224 14 , , , cord-005453-4057qib7 11224 15 is be VBZ cord-005453-4057qib7 11224 16 a a DT cord-005453-4057qib7 11224 17 widely widely RB cord-005453-4057qib7 11224 18 used use VBN cord-005453-4057qib7 11224 19 treatment treatment NN cord-005453-4057qib7 11224 20 approach approach NN cord-005453-4057qib7 11224 21 to to TO cord-005453-4057qib7 11224 22 minimize minimize VB cord-005453-4057qib7 11224 23 the the DT cord-005453-4057qib7 11224 24 risk risk NN cord-005453-4057qib7 11224 25 of of IN cord-005453-4057qib7 11224 26 relapse relapse NN cord-005453-4057qib7 11224 27 post post JJ cord-005453-4057qib7 11224 28 autologous autologous JJ cord-005453-4057qib7 11224 29 stem stem NN cord-005453-4057qib7 11224 30 cell cell NN cord-005453-4057qib7 11224 31 transplantation transplantation NN cord-005453-4057qib7 11224 32 ( ( -LRB- cord-005453-4057qib7 11224 33 ASCT ASCT NNP cord-005453-4057qib7 11224 34 ) ) -RRB- cord-005453-4057qib7 11224 35 . . . cord-005453-4057qib7 11225 1 However however RB cord-005453-4057qib7 11225 2 , , , cord-005453-4057qib7 11225 3 the the DT cord-005453-4057qib7 11225 4 proper proper JJ cord-005453-4057qib7 11225 5 time time NN cord-005453-4057qib7 11225 6 for for IN cord-005453-4057qib7 11225 7 irradiation irradiation NN cord-005453-4057qib7 11225 8 treatment treatment NN cord-005453-4057qib7 11225 9 remains remain VBZ cord-005453-4057qib7 11225 10 controversial controversial JJ cord-005453-4057qib7 11225 11 . . . cord-005453-4057qib7 11226 1 Adjuvant Adjuvant NNP cord-005453-4057qib7 11226 2 IFRT IFRT NNP cord-005453-4057qib7 11226 3 ( ( -LRB- cord-005453-4057qib7 11226 4 adj adj NNP cord-005453-4057qib7 11226 5 - - HYPH cord-005453-4057qib7 11226 6 IFRT IFRT NNP cord-005453-4057qib7 11226 7 ) ) -RRB- cord-005453-4057qib7 11226 8 in in IN cord-005453-4057qib7 11226 9 pre pre JJ cord-005453-4057qib7 11226 10 - - JJ cord-005453-4057qib7 11226 11 ASCT asct JJ cord-005453-4057qib7 11226 12 period period NN cord-005453-4057qib7 11226 13 could could MD cord-005453-4057qib7 11226 14 cause cause VB cord-005453-4057qib7 11226 15 undesirable undesirable JJ cord-005453-4057qib7 11226 16 toxicity toxicity NN cord-005453-4057qib7 11226 17 which which WDT cord-005453-4057qib7 11226 18 might may MD cord-005453-4057qib7 11226 19 delays delay NNS cord-005453-4057qib7 11226 20 or or CC cord-005453-4057qib7 11226 21 even even RB cord-005453-4057qib7 11226 22 cancel cancel VB cord-005453-4057qib7 11226 23 the the DT cord-005453-4057qib7 11226 24 ASCT ASCT NNP cord-005453-4057qib7 11226 25 resulting result VBG cord-005453-4057qib7 11226 26 in in IN cord-005453-4057qib7 11226 27 increased increase VBN cord-005453-4057qib7 11226 28 risk risk NN cord-005453-4057qib7 11226 29 of of IN cord-005453-4057qib7 11226 30 relapse relapse NN cord-005453-4057qib7 11226 31 , , , cord-005453-4057qib7 11226 32 or or CC cord-005453-4057qib7 11226 33 could could MD cord-005453-4057qib7 11226 34 affect affect VB cord-005453-4057qib7 11226 35 the the DT cord-005453-4057qib7 11226 36 marrow marrow NN cord-005453-4057qib7 11226 37 environmental environmental JJ cord-005453-4057qib7 11226 38 and and CC cord-005453-4057qib7 11226 39 marrow marrow NN cord-005453-4057qib7 11226 40 niche niche NN cord-005453-4057qib7 11226 41 resulting result VBG cord-005453-4057qib7 11226 42 thus thus RB cord-005453-4057qib7 11226 43 in in IN cord-005453-4057qib7 11226 44 impaired impaired JJ cord-005453-4057qib7 11226 45 engraftment engraftment NN cord-005453-4057qib7 11226 46 . . . cord-005453-4057qib7 11227 1 On on IN cord-005453-4057qib7 11227 2 the the DT cord-005453-4057qib7 11227 3 other other JJ cord-005453-4057qib7 11227 4 hand hand NN cord-005453-4057qib7 11227 5 , , , cord-005453-4057qib7 11227 6 the the DT cord-005453-4057qib7 11227 7 ajd ajd NNP cord-005453-4057qib7 11227 8 - - HYPH cord-005453-4057qib7 11227 9 IFTR IFTR NNP cord-005453-4057qib7 11227 10 in in IN cord-005453-4057qib7 11227 11 the the DT cord-005453-4057qib7 11227 12 early early JJ cord-005453-4057qib7 11227 13 post post JJ cord-005453-4057qib7 11227 14 - - JJ cord-005453-4057qib7 11227 15 ASCT asct JJ cord-005453-4057qib7 11227 16 period period NN cord-005453-4057qib7 11227 17 , , , cord-005453-4057qib7 11227 18 upon upon IN cord-005453-4057qib7 11227 19 marrow marrow NN cord-005453-4057qib7 11227 20 recovery recovery NN cord-005453-4057qib7 11227 21 , , , cord-005453-4057qib7 11227 22 offers offer VBZ cord-005453-4057qib7 11227 23 a a DT cord-005453-4057qib7 11227 24 potential potential JJ cord-005453-4057qib7 11227 25 advantage advantage NN cord-005453-4057qib7 11227 26 by by IN cord-005453-4057qib7 11227 27 delivering deliver VBG cord-005453-4057qib7 11227 28 irradiation irradiation NN cord-005453-4057qib7 11227 29 after after IN cord-005453-4057qib7 11227 30 sufficient sufficient JJ cord-005453-4057qib7 11227 31 disease disease NN cord-005453-4057qib7 11227 32 response response NN cord-005453-4057qib7 11227 33 , , , cord-005453-4057qib7 11227 34 without without IN cord-005453-4057qib7 11227 35 affecting affect VBG cord-005453-4057qib7 11227 36 the the DT cord-005453-4057qib7 11227 37 engraftment engraftment NN cord-005453-4057qib7 11227 38 . . . cord-005453-4057qib7 11228 1 In in IN cord-005453-4057qib7 11228 2 this this DT cord-005453-4057qib7 11228 3 retrospective retrospective JJ cord-005453-4057qib7 11228 4 study study NN cord-005453-4057qib7 11228 5 we -PRON- PRP cord-005453-4057qib7 11228 6 evaluated evaluate VBD cord-005453-4057qib7 11228 7 the the DT cord-005453-4057qib7 11228 8 safety safety NN cord-005453-4057qib7 11228 9 and and CC cord-005453-4057qib7 11228 10 efficacy efficacy NN cord-005453-4057qib7 11228 11 of of IN cord-005453-4057qib7 11228 12 the the DT cord-005453-4057qib7 11228 13 IFRT IFRT NNP cord-005453-4057qib7 11228 14 as as IN cord-005453-4057qib7 11228 15 adjuvant adjuvant JJ cord-005453-4057qib7 11228 16 treatment treatment NN cord-005453-4057qib7 11228 17 in in IN cord-005453-4057qib7 11228 18 patients patient NNS cord-005453-4057qib7 11228 19 who who WP cord-005453-4057qib7 11228 20 had have VBD cord-005453-4057qib7 11228 21 previously previously RB cord-005453-4057qib7 11228 22 treated treat VBN cord-005453-4057qib7 11228 23 with with IN cord-005453-4057qib7 11228 24 ASCT ASCT NNP cord-005453-4057qib7 11228 25 for for IN cord-005453-4057qib7 11228 26 relapsed relapsed JJ cord-005453-4057qib7 11228 27 or or CC cord-005453-4057qib7 11228 28 refractory refractory JJ cord-005453-4057qib7 11228 29 lymphomas lymphoma NNS cord-005453-4057qib7 11228 30 . . . cord-005453-4057qib7 11229 1 Methods method NNS cord-005453-4057qib7 11229 2 : : : cord-005453-4057qib7 11229 3 Twenty twenty CD cord-005453-4057qib7 11229 4 - - HYPH cord-005453-4057qib7 11229 5 three three CD cord-005453-4057qib7 11229 6 patients patient NNS cord-005453-4057qib7 11229 7 ( ( -LRB- cord-005453-4057qib7 11229 8 Hodgkin=14 Hodgkin=14 NNP cord-005453-4057qib7 11229 9 , , , cord-005453-4057qib7 11229 10 Non non JJ cord-005453-4057qib7 11229 11 - - NN cord-005453-4057qib7 11229 12 Hodgkin=9 hodgkin=9 JJ cord-005453-4057qib7 11229 13 ) ) -RRB- cord-005453-4057qib7 11229 14 , , , cord-005453-4057qib7 11229 15 aged age VBN cord-005453-4057qib7 11229 16 of of IN cord-005453-4057qib7 11229 17 34(16 34(16 CD cord-005453-4057qib7 11229 18 - - SYM cord-005453-4057qib7 11229 19 76 76 CD cord-005453-4057qib7 11229 20 ) ) -RRB- cord-005453-4057qib7 11229 21 years year NNS cord-005453-4057qib7 11229 22 , , , cord-005453-4057qib7 11229 23 underwent undergo VBD cord-005453-4057qib7 11229 24 ASCT ASCT NNP cord-005453-4057qib7 11229 25 , , , cord-005453-4057qib7 11229 26 for for IN cord-005453-4057qib7 11229 27 primary primary JJ cord-005453-4057qib7 11229 28 refractory refractory NN cord-005453-4057qib7 11229 29 ( ( -LRB- cord-005453-4057qib7 11229 30 n=15 n=15 NNP cord-005453-4057qib7 11229 31 ) ) -RRB- cord-005453-4057qib7 11229 32 or or CC cord-005453-4057qib7 11229 33 relapsed relapse VBN cord-005453-4057qib7 11229 34 ( ( -LRB- cord-005453-4057qib7 11229 35 n=8 n=8 NN cord-005453-4057qib7 11229 36 ) ) -RRB- cord-005453-4057qib7 11229 37 disease disease NN cord-005453-4057qib7 11229 38 . . . cord-005453-4057qib7 11230 1 Patients patient NNS cord-005453-4057qib7 11230 2 who who WP cord-005453-4057qib7 11230 3 had have VBD cord-005453-4057qib7 11230 4 bulky bulky JJ cord-005453-4057qib7 11230 5 disease disease NN cord-005453-4057qib7 11230 6 at at IN cord-005453-4057qib7 11230 7 the the DT cord-005453-4057qib7 11230 8 time time NN cord-005453-4057qib7 11230 9 of of IN cord-005453-4057qib7 11230 10 relapse relapse NN cord-005453-4057qib7 11230 11 or or CC cord-005453-4057qib7 11230 12 those those DT cord-005453-4057qib7 11230 13 with with IN cord-005453-4057qib7 11230 14 residual residual JJ cord-005453-4057qib7 11230 15 mass mass JJ cord-005453-4057qib7 11230 16 post post NN cord-005453-4057qib7 11230 17 salvage salvage NN cord-005453-4057qib7 11230 18 treatment treatment NN cord-005453-4057qib7 11230 19 , , , cord-005453-4057qib7 11230 20 were be VBD cord-005453-4057qib7 11230 21 considered consider VBN cord-005453-4057qib7 11230 22 as as IN cord-005453-4057qib7 11230 23 candidates candidate NNS cord-005453-4057qib7 11230 24 for for IN cord-005453-4057qib7 11230 25 adj adj JJ cord-005453-4057qib7 11230 26 - - HYPH cord-005453-4057qib7 11230 27 IFRT IFRT NNP cord-005453-4057qib7 11230 28 , , , cord-005453-4057qib7 11230 29 early early RB cord-005453-4057qib7 11230 30 ( ( -LRB- cord-005453-4057qib7 11230 31 within within IN cord-005453-4057qib7 11230 32 2 2 CD cord-005453-4057qib7 11230 33 - - SYM cord-005453-4057qib7 11230 34 3 3 CD cord-005453-4057qib7 11230 35 months month NNS cord-005453-4057qib7 11230 36 ) ) -RRB- cord-005453-4057qib7 11230 37 after after IN cord-005453-4057qib7 11230 38 documentation documentation NN cord-005453-4057qib7 11230 39 of of IN cord-005453-4057qib7 11230 40 autologous autologous JJ cord-005453-4057qib7 11230 41 stem stem NN cord-005453-4057qib7 11230 42 cells cell NNS cord-005453-4057qib7 11230 43 engraftment engraftment NN cord-005453-4057qib7 11230 44 . . . cord-005453-4057qib7 11231 1 All all DT cord-005453-4057qib7 11231 2 patients patient NNS cord-005453-4057qib7 11231 3 proceeded proceed VBD cord-005453-4057qib7 11231 4 to to IN cord-005453-4057qib7 11231 5 ASCT ASCT NNP cord-005453-4057qib7 11231 6 with with IN cord-005453-4057qib7 11231 7 chemosensitive chemosensitive JJ cord-005453-4057qib7 11231 8 disease disease NN cord-005453-4057qib7 11231 9 after after IN cord-005453-4057qib7 11231 10 a a DT cord-005453-4057qib7 11231 11 median median NN cord-005453-4057qib7 11231 12 of of IN cord-005453-4057qib7 11231 13 2 2 CD cord-005453-4057qib7 11231 14 lines line NNS cord-005453-4057qib7 11231 15 of of IN cord-005453-4057qib7 11231 16 salvage salvage NN cord-005453-4057qib7 11231 17 therapy therapy NN cord-005453-4057qib7 11231 18 . . . cord-005453-4057qib7 11232 1 At at IN cord-005453-4057qib7 11232 2 the the DT cord-005453-4057qib7 11232 3 time time NN cord-005453-4057qib7 11232 4 of of IN cord-005453-4057qib7 11232 5 ASCT ASCT NNP cord-005453-4057qib7 11232 6 20 20 CD cord-005453-4057qib7 11232 7 patients patient NNS cord-005453-4057qib7 11232 8 ( ( -LRB- cord-005453-4057qib7 11232 9 80 80 CD cord-005453-4057qib7 11232 10 % % NN cord-005453-4057qib7 11232 11 ) ) -RRB- cord-005453-4057qib7 11232 12 had have VBD cord-005453-4057qib7 11232 13 residual residual JJ cord-005453-4057qib7 11232 14 disease disease NN cord-005453-4057qib7 11232 15 while while IN cord-005453-4057qib7 11232 16 4(20 4(20 CD cord-005453-4057qib7 11232 17 % % NN cord-005453-4057qib7 11232 18 ) ) -RRB- cord-005453-4057qib7 11232 19 evaluated evaluate VBN cord-005453-4057qib7 11232 20 to to TO cord-005453-4057qib7 11232 21 be be VB cord-005453-4057qib7 11232 22 in in IN cord-005453-4057qib7 11232 23 complete complete JJ cord-005453-4057qib7 11232 24 remission remission NN cord-005453-4057qib7 11232 25 . . . cord-005453-4057qib7 11233 1 The the DT cord-005453-4057qib7 11233 2 preparative preparative JJ cord-005453-4057qib7 11233 3 regimens regimen NNS cord-005453-4057qib7 11233 4 were be VBD cord-005453-4057qib7 11233 5 : : : cord-005453-4057qib7 11233 6 single single JJ cord-005453-4057qib7 11233 7 - - HYPH cord-005453-4057qib7 11233 8 agent agent NN cord-005453-4057qib7 11233 9 Melphalan Melphalan NNP cord-005453-4057qib7 11233 10 ( ( -LRB- cord-005453-4057qib7 11233 11 n=9 n=9 NN cord-005453-4057qib7 11233 12 ) ) -RRB- cord-005453-4057qib7 11233 13 , , , cord-005453-4057qib7 11233 14 Busulfan Busulfan NNP cord-005453-4057qib7 11233 15 - - HYPH cord-005453-4057qib7 11233 16 Etoposide Etoposide NNP cord-005453-4057qib7 11233 17 - - HYPH cord-005453-4057qib7 11233 18 Melphalan Melphalan NNP cord-005453-4057qib7 11233 19 ( ( -LRB- cord-005453-4057qib7 11233 20 n=7 n=7 NNS cord-005453-4057qib7 11233 21 ) ) -RRB- cord-005453-4057qib7 11233 22 , , , cord-005453-4057qib7 11233 23 BEAM BEAM NNP cord-005453-4057qib7 11233 24 ( ( -LRB- cord-005453-4057qib7 11233 25 n=5 n=5 NNP cord-005453-4057qib7 11233 26 ) ) -RRB- cord-005453-4057qib7 11233 27 and and CC cord-005453-4057qib7 11233 28 Bendamustin Bendamustin NNP cord-005453-4057qib7 11233 29 - - HYPH cord-005453-4057qib7 11233 30 Etoposide Etoposide NNP cord-005453-4057qib7 11233 31 - - HYPH cord-005453-4057qib7 11233 32 Cytarabine Cytarabine NNP cord-005453-4057qib7 11233 33 - - HYPH cord-005453-4057qib7 11233 34 Melphalan Melphalan NNP cord-005453-4057qib7 11233 35 ( ( -LRB- cord-005453-4057qib7 11233 36 n=3 n=3 NN cord-005453-4057qib7 11233 37 ) ) -RRB- cord-005453-4057qib7 11233 38 . . . cord-005453-4057qib7 11234 1 Filgrastim Filgrastim NNP cord-005453-4057qib7 11234 2 was be VBD cord-005453-4057qib7 11234 3 given give VBN cord-005453-4057qib7 11234 4 till till IN cord-005453-4057qib7 11234 5 neutrophills neutrophills NNP cord-005453-4057qib7 11234 6 recovery recovery NN cord-005453-4057qib7 11234 7 , , , cord-005453-4057qib7 11234 8 while while IN cord-005453-4057qib7 11234 9 prophylaxis prophylaxis NN cord-005453-4057qib7 11234 10 against against IN cord-005453-4057qib7 11234 11 bacteria bacteria NNS cord-005453-4057qib7 11234 12 , , , cord-005453-4057qib7 11234 13 fungus fungus NN cord-005453-4057qib7 11234 14 , , , cord-005453-4057qib7 11234 15 viruses virus NNS cord-005453-4057qib7 11234 16 and and CC cord-005453-4057qib7 11234 17 PCP PCP NNP cord-005453-4057qib7 11234 18 were be VBD cord-005453-4057qib7 11234 19 administered administer VBN cord-005453-4057qib7 11234 20 till till IN cord-005453-4057qib7 11234 21 the the DT cord-005453-4057qib7 11234 22 completion completion NN cord-005453-4057qib7 11234 23 of of IN cord-005453-4057qib7 11234 24 adj adj JJ cord-005453-4057qib7 11234 25 - - HYPH cord-005453-4057qib7 11234 26 IFRT IFRT NNP cord-005453-4057qib7 11234 27 . . . cord-005453-4057qib7 11235 1 Results result NNS cord-005453-4057qib7 11235 2 : : : cord-005453-4057qib7 11236 1 All all DT cord-005453-4057qib7 11236 2 patients patient NNS cord-005453-4057qib7 11236 3 engrafted engraft VBD cord-005453-4057qib7 11236 4 promptly promptly RB cord-005453-4057qib7 11236 5 and and CC cord-005453-4057qib7 11236 6 successfully successfully RB cord-005453-4057qib7 11236 7 . . . cord-005453-4057qib7 11237 1 No no DT cord-005453-4057qib7 11237 2 patient patient NN cord-005453-4057qib7 11237 3 experienced experience VBD cord-005453-4057qib7 11237 4 any any DT cord-005453-4057qib7 11237 5 severe severe JJ cord-005453-4057qib7 11237 6 toxicity toxicity NN cord-005453-4057qib7 11237 7 or or CC cord-005453-4057qib7 11237 8 active active JJ cord-005453-4057qib7 11237 9 infection infection NN cord-005453-4057qib7 11237 10 before before IN cord-005453-4057qib7 11237 11 adj adj JJ cord-005453-4057qib7 11237 12 - - HYPH cord-005453-4057qib7 11237 13 IFTR IFTR NNP cord-005453-4057qib7 11237 14 . . . cord-005453-4057qib7 11238 1 Though though IN cord-005453-4057qib7 11238 2 our -PRON- PRP$ cord-005453-4057qib7 11238 3 plan plan NN cord-005453-4057qib7 11238 4 was be VBD cord-005453-4057qib7 11238 5 to to TO cord-005453-4057qib7 11238 6 proceed proceed VB cord-005453-4057qib7 11238 7 with with IN cord-005453-4057qib7 11238 8 adj adj JJ cord-005453-4057qib7 11238 9 - - HYPH cord-005453-4057qib7 11238 10 IFRT ifrt NN cord-005453-4057qib7 11238 11 within within IN cord-005453-4057qib7 11238 12 3 3 CD cord-005453-4057qib7 11238 13 months month NNS cord-005453-4057qib7 11238 14 post post NN cord-005453-4057qib7 11238 15 ASCT ASCT NNP cord-005453-4057qib7 11238 16 , , , cord-005453-4057qib7 11238 17 finally finally RB cord-005453-4057qib7 11238 18 it -PRON- PRP cord-005453-4057qib7 11238 19 was be VBD cord-005453-4057qib7 11238 20 delivered deliver VBN cord-005453-4057qib7 11238 21 after after IN cord-005453-4057qib7 11238 22 a a DT cord-005453-4057qib7 11238 23 median median NN cord-005453-4057qib7 11238 24 of of IN cord-005453-4057qib7 11238 25 4.5 4.5 CD cord-005453-4057qib7 11238 26 ( ( -LRB- cord-005453-4057qib7 11238 27 2 2 CD cord-005453-4057qib7 11238 28 - - SYM cord-005453-4057qib7 11238 29 7 7 CD cord-005453-4057qib7 11238 30 ) ) -RRB- cord-005453-4057qib7 11238 31 months month NNS cord-005453-4057qib7 11238 32 ; ; : cord-005453-4057qib7 11238 33 the the DT cord-005453-4057qib7 11238 34 median median JJ cord-005453-4057qib7 11238 35 radiation radiation NN cord-005453-4057qib7 11238 36 dose dose NN cord-005453-4057qib7 11238 37 was be VBD cord-005453-4057qib7 11238 38 30(24 30(24 CD cord-005453-4057qib7 11238 39 - - SYM cord-005453-4057qib7 11238 40 36 36 CD cord-005453-4057qib7 11239 1 ) ) -RRB- cord-005453-4057qib7 11239 2 Gy Gy NNP cord-005453-4057qib7 11239 3 . . . cord-005453-4057qib7 11240 1 Ten ten CD cord-005453-4057qib7 11240 2 patients patient NNS cord-005453-4057qib7 11240 3 received receive VBD cord-005453-4057qib7 11240 4 radiotherapy radiotherapy NN cord-005453-4057qib7 11240 5 in in IN cord-005453-4057qib7 11240 6 the the DT cord-005453-4057qib7 11240 7 mediastinum mediastinum NN cord-005453-4057qib7 11240 8 , , , cord-005453-4057qib7 11240 9 9 9 CD cord-005453-4057qib7 11240 10 in in IN cord-005453-4057qib7 11240 11 the the DT cord-005453-4057qib7 11240 12 abdomen abdomen NN cord-005453-4057qib7 11240 13 / / SYM cord-005453-4057qib7 11240 14 pelvis/ pelvis/ JJ cord-005453-4057qib7 11240 15 inguinal inguinal JJ cord-005453-4057qib7 11240 16 area area NN cord-005453-4057qib7 11240 17 3 3 CD cord-005453-4057qib7 11240 18 in in IN cord-005453-4057qib7 11240 19 the the DT cord-005453-4057qib7 11240 20 neck neck NN cord-005453-4057qib7 11240 21 , , , cord-005453-4057qib7 11240 22 and and CC cord-005453-4057qib7 11240 23 1 1 CD cord-005453-4057qib7 11240 24 in in IN cord-005453-4057qib7 11240 25 the the DT cord-005453-4057qib7 11240 26 left left JJ cord-005453-4057qib7 11240 27 leg leg NN cord-005453-4057qib7 11240 28 . . . cord-005453-4057qib7 11241 1 The the DT cord-005453-4057qib7 11241 2 adj adj JJ cord-005453-4057qib7 11241 3 - - HYPH cord-005453-4057qib7 11241 4 IFRT IFRT NNP cord-005453-4057qib7 11241 5 was be VBD cord-005453-4057qib7 11241 6 well well RB cord-005453-4057qib7 11241 7 tolerated tolerate VBN cord-005453-4057qib7 11241 8 . . . cord-005453-4057qib7 11242 1 No no DT cord-005453-4057qib7 11242 2 patient patient NN cord-005453-4057qib7 11242 3 experienced experience VBD cord-005453-4057qib7 11242 4 toxicity toxicity NN cord-005453-4057qib7 11242 5 grade grade NN cord-005453-4057qib7 11242 6 > > XX cord-005453-4057qib7 11243 1 3 3 LS cord-005453-4057qib7 11244 1 and and CC cord-005453-4057qib7 11244 2 none none NN cord-005453-4057qib7 11244 3 required require VBD cord-005453-4057qib7 11244 4 hospitalization hospitalization NN cord-005453-4057qib7 11244 5 . . . cord-005453-4057qib7 11245 1 Currently currently RB cord-005453-4057qib7 11245 2 , , , cord-005453-4057qib7 11245 3 after after IN cord-005453-4057qib7 11245 4 a a DT cord-005453-4057qib7 11245 5 median median JJ cord-005453-4057qib7 11245 6 follow follow NN cord-005453-4057qib7 11245 7 - - HYPH cord-005453-4057qib7 11245 8 up up NN cord-005453-4057qib7 11245 9 of of IN cord-005453-4057qib7 11245 10 2(2 2(2 NNP cord-005453-4057qib7 11245 11 - - SYM cord-005453-4057qib7 11245 12 5 5 CD cord-005453-4057qib7 11245 13 ) ) -RRB- cord-005453-4057qib7 11245 14 years year NNS cord-005453-4057qib7 11245 15 , , , cord-005453-4057qib7 11245 16 19/23 19/23 CD cord-005453-4057qib7 11245 17 patients patient NNS cord-005453-4057qib7 11245 18 are be VBP cord-005453-4057qib7 11245 19 alive alive JJ cord-005453-4057qib7 11245 20 and and CC cord-005453-4057qib7 11245 21 well well RB cord-005453-4057qib7 11245 22 ; ; : cord-005453-4057qib7 11245 23 the the DT cord-005453-4057qib7 11245 24 5-years 5-years CD cord-005453-4057qib7 11245 25 overall overall JJ cord-005453-4057qib7 11245 26 and and CC cord-005453-4057qib7 11245 27 progression progression NN cord-005453-4057qib7 11245 28 free free JJ cord-005453-4057qib7 11245 29 survival survival NN cord-005453-4057qib7 11245 30 rates rate NNS cord-005453-4057qib7 11245 31 are be VBP cord-005453-4057qib7 11245 32 75 75 CD cord-005453-4057qib7 11245 33 % % NN cord-005453-4057qib7 11245 34 and and CC cord-005453-4057qib7 11245 35 55 55 CD cord-005453-4057qib7 11245 36 % % NN cord-005453-4057qib7 11245 37 respectively respectively RB cord-005453-4057qib7 11245 38 . . . cord-005453-4057qib7 11246 1 Four four CD cord-005453-4057qib7 11246 2 patients patient NNS cord-005453-4057qib7 11246 3 died die VBD cord-005453-4057qib7 11246 4 ; ; : cord-005453-4057qib7 11246 5 2 2 CD cord-005453-4057qib7 11246 6 due due JJ cord-005453-4057qib7 11246 7 to to IN cord-005453-4057qib7 11246 8 relapsed relapse VBN cord-005453-4057qib7 11246 9 disease disease NN cord-005453-4057qib7 11246 10 and and CC cord-005453-4057qib7 11246 11 2 2 CD cord-005453-4057qib7 11246 12 heavily heavily RB cord-005453-4057qib7 11246 13 pretreated pretreate VBN cord-005453-4057qib7 11246 14 patients patient NNS cord-005453-4057qib7 11246 15 due due JJ cord-005453-4057qib7 11246 16 to to IN cord-005453-4057qib7 11247 1 secondary secondary JJ cord-005453-4057qib7 11247 2 myelodyspalstic myelodyspalstic JJ cord-005453-4057qib7 11247 3 syndrome syndrome NN cord-005453-4057qib7 11247 4 Conclusions Conclusions NNPS cord-005453-4057qib7 11247 5 : : : cord-005453-4057qib7 11248 1 In in IN cord-005453-4057qib7 11248 2 our -PRON- PRP$ cord-005453-4057qib7 11248 3 study study NN cord-005453-4057qib7 11248 4 , , , cord-005453-4057qib7 11248 5 the the DT cord-005453-4057qib7 11248 6 adj adj JJ cord-005453-4057qib7 11248 7 - - HYPH cord-005453-4057qib7 11248 8 IFRT ifrt NN cord-005453-4057qib7 11248 9 in in IN cord-005453-4057qib7 11248 10 the the DT cord-005453-4057qib7 11248 11 early early JJ cord-005453-4057qib7 11248 12 post post JJ cord-005453-4057qib7 11248 13 transplant transplant NN cord-005453-4057qib7 11248 14 period period NN cord-005453-4057qib7 11248 15 demonstrated demonstrate VBD cord-005453-4057qib7 11248 16 a a DT cord-005453-4057qib7 11248 17 safe safe JJ cord-005453-4057qib7 11248 18 and and CC cord-005453-4057qib7 11248 19 well well RB cord-005453-4057qib7 11248 20 - - HYPH cord-005453-4057qib7 11248 21 tolerated tolerate VBN cord-005453-4057qib7 11248 22 profile profile NN cord-005453-4057qib7 11248 23 . . . cord-005453-4057qib7 11249 1 Taking take VBG cord-005453-4057qib7 11249 2 into into IN cord-005453-4057qib7 11249 3 consideration consideration NN cord-005453-4057qib7 11249 4 the the DT cord-005453-4057qib7 11249 5 poor poor JJ cord-005453-4057qib7 11249 6 risk risk NN cord-005453-4057qib7 11249 7 status status NN cord-005453-4057qib7 11249 8 of of IN cord-005453-4057qib7 11249 9 our -PRON- PRP$ cord-005453-4057qib7 11249 10 patients patient NNS cord-005453-4057qib7 11249 11 ( ( -LRB- cord-005453-4057qib7 11249 12 residual residual JJ cord-005453-4057qib7 11249 13 disease disease NN cord-005453-4057qib7 11249 14 post post NN cord-005453-4057qib7 11249 15 salvage salvage NN cord-005453-4057qib7 11249 16 regimen regimen NN cord-005453-4057qib7 11249 17 or or CC cord-005453-4057qib7 11249 18 bulky bulky JJ cord-005453-4057qib7 11249 19 disease disease NN cord-005453-4057qib7 11249 20 at at IN cord-005453-4057qib7 11249 21 the the DT cord-005453-4057qib7 11249 22 time time NN cord-005453-4057qib7 11249 23 of of IN cord-005453-4057qib7 11249 24 relapse relapse NN cord-005453-4057qib7 11249 25 ) ) -RRB- cord-005453-4057qib7 11249 26 , , , cord-005453-4057qib7 11249 27 the the DT cord-005453-4057qib7 11249 28 promising promising JJ cord-005453-4057qib7 11249 29 overall overall NN cord-005453-4057qib7 11249 30 and and CC cord-005453-4057qib7 11249 31 progression progression NN cord-005453-4057qib7 11249 32 free free JJ cord-005453-4057qib7 11249 33 survival survival NN cord-005453-4057qib7 11249 34 rates rate NNS cord-005453-4057qib7 11249 35 suggested suggest VBD cord-005453-4057qib7 11249 36 that that IN cord-005453-4057qib7 11249 37 adj adj JJ cord-005453-4057qib7 11249 38 - - HYPH cord-005453-4057qib7 11249 39 IFRT IFRT NNP cord-005453-4057qib7 11249 40 post post NN cord-005453-4057qib7 11249 41 ASCT ASCT NNP cord-005453-4057qib7 11249 42 is be VBZ cord-005453-4057qib7 11249 43 also also RB cord-005453-4057qib7 11249 44 an an DT cord-005453-4057qib7 11249 45 effective effective JJ cord-005453-4057qib7 11249 46 approach approach NN cord-005453-4057qib7 11249 47 . . . cord-005453-4057qib7 11250 1 Well well UH cord-005453-4057qib7 11250 2 designed design VBN cord-005453-4057qib7 11250 3 trials trial NNS cord-005453-4057qib7 11250 4 are be VBP cord-005453-4057qib7 11250 5 needed need VBN cord-005453-4057qib7 11250 6 to to TO cord-005453-4057qib7 11250 7 clarify clarify VB cord-005453-4057qib7 11250 8 the the DT cord-005453-4057qib7 11250 9 role role NN cord-005453-4057qib7 11250 10 and and CC cord-005453-4057qib7 11250 11 the the DT cord-005453-4057qib7 11250 12 appropriate appropriate JJ cord-005453-4057qib7 11250 13 time time NN cord-005453-4057qib7 11250 14 of of IN cord-005453-4057qib7 11250 15 radiotherapy radiotherapy NN cord-005453-4057qib7 11250 16 in in IN cord-005453-4057qib7 11250 17 the the DT cord-005453-4057qib7 11250 18 ASCT ASCT NNP cord-005453-4057qib7 11250 19 setting set VBG cord-005453-4057qib7 11250 20 Disclosure Disclosure NNP cord-005453-4057qib7 11250 21 : : : cord-005453-4057qib7 11250 22 No no DT cord-005453-4057qib7 11250 23 conflict conflict NN cord-005453-4057qib7 11250 24 of of IN cord-005453-4057qib7 11250 25 interest interest NN cord-005453-4057qib7 11250 26 Adverse adverse JJ cord-005453-4057qib7 11250 27 prognostic prognostic JJ cord-005453-4057qib7 11250 28 impact impact NN cord-005453-4057qib7 11250 29 of of IN cord-005453-4057qib7 11250 30 pre pre JJ cord-005453-4057qib7 11250 31 - - JJ cord-005453-4057qib7 11250 32 transplant transplant JJ cord-005453-4057qib7 11250 33 neutrophil/ neutrophil/ ADD cord-005453-4057qib7 11250 34 lymphocyte lymphocyte NN cord-005453-4057qib7 11250 35 ratio ratio NN cord-005453-4057qib7 11250 36 in in IN cord-005453-4057qib7 11250 37 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 11250 38 disorders disorder NNS cord-005453-4057qib7 11250 39 Background Background NNP cord-005453-4057qib7 11250 40 : : : cord-005453-4057qib7 11250 41 BrentuximabVedotin(BV brentuximabvedotin(bv RB cord-005453-4057qib7 11250 42 ) ) -RRB- cord-005453-4057qib7 11251 1 is be VBZ cord-005453-4057qib7 11251 2 a a DT cord-005453-4057qib7 11251 3 chimeric chimeric JJ cord-005453-4057qib7 11251 4 anti anti JJ cord-005453-4057qib7 11251 5 CD30 CD30 NNP cord-005453-4057qib7 11251 6 IgG1 igg1 NN cord-005453-4057qib7 11251 7 antibody antibody NN cord-005453-4057qib7 11251 8 , , , cord-005453-4057qib7 11251 9 conjugated conjugate VBN cord-005453-4057qib7 11251 10 to to IN cord-005453-4057qib7 11251 11 synthetic synthetic JJ cord-005453-4057qib7 11251 12 antitubulinmomomethylauristatin antitubulinmomomethylauristatin NNS cord-005453-4057qib7 11251 13 . . . cord-005453-4057qib7 11252 1 BV BV NNP cord-005453-4057qib7 11252 2 is be VBZ cord-005453-4057qib7 11252 3 approved approve VBN cord-005453-4057qib7 11252 4 for for IN cord-005453-4057qib7 11252 5 the the DT cord-005453-4057qib7 11252 6 treatment treatment NN cord-005453-4057qib7 11252 7 of of IN cord-005453-4057qib7 11252 8 classical classical JJ cord-005453-4057qib7 11252 9 Hodgkin Hodgkin NNP cord-005453-4057qib7 11252 10 lymphoma lymphoma NN cord-005453-4057qib7 11252 11 ( ( -LRB- cord-005453-4057qib7 11252 12 HL HL NNP cord-005453-4057qib7 11252 13 ) ) -RRB- cord-005453-4057qib7 11252 14 in in IN cord-005453-4057qib7 11252 15 relapse relapse NN cord-005453-4057qib7 11252 16 either either CC cord-005453-4057qib7 11252 17 after after IN cord-005453-4057qib7 11252 18 autologous autologous JJ cord-005453-4057qib7 11252 19 stem stem NN cord-005453-4057qib7 11252 20 cell cell NN cord-005453-4057qib7 11252 21 transplantation transplantation NN cord-005453-4057qib7 11252 22 ( ( -LRB- cord-005453-4057qib7 11252 23 ASCT ASCT NNP cord-005453-4057qib7 11252 24 ) ) -RRB- cord-005453-4057qib7 11252 25 or or CC cord-005453-4057qib7 11252 26 after after IN cord-005453-4057qib7 11252 27 two two CD cord-005453-4057qib7 11252 28 lines line NNS cord-005453-4057qib7 11252 29 of of IN cord-005453-4057qib7 11252 30 combination combination NN cord-005453-4057qib7 11252 31 chemotherapy chemotherapy NN cord-005453-4057qib7 11252 32 in in IN cord-005453-4057qib7 11252 33 transplant transplant NN cord-005453-4057qib7 11252 34 ineligible ineligible JJ cord-005453-4057qib7 11252 35 patients patient NNS cord-005453-4057qib7 11252 36 . . . cord-005453-4057qib7 11253 1 The the DT cord-005453-4057qib7 11253 2 AETHERA AETHERA NNP cord-005453-4057qib7 11253 3 trial trial NN cord-005453-4057qib7 11253 4 revealed reveal VBD cord-005453-4057qib7 11253 5 increased increase VBN cord-005453-4057qib7 11253 6 PFS PFS NNP cord-005453-4057qib7 11253 7 when when WRB cord-005453-4057qib7 11253 8 BV BV NNP cord-005453-4057qib7 11253 9 is be VBZ cord-005453-4057qib7 11253 10 used use VBN cord-005453-4057qib7 11253 11 as as IN cord-005453-4057qib7 11253 12 maintenance maintenance NN cord-005453-4057qib7 11253 13 therapy therapy NN cord-005453-4057qib7 11253 14 for for IN cord-005453-4057qib7 11253 15 16 16 CD cord-005453-4057qib7 11253 16 cycles cycle NNS cord-005453-4057qib7 11253 17 in in IN cord-005453-4057qib7 11253 18 high high JJ cord-005453-4057qib7 11253 19 risk risk NN cord-005453-4057qib7 11253 20 patients patient NNS cord-005453-4057qib7 11253 21 after after IN cord-005453-4057qib7 11253 22 ASCT ASCT NNP cord-005453-4057qib7 11253 23 . . . cord-005453-4057qib7 11254 1 However however RB cord-005453-4057qib7 11254 2 , , , cord-005453-4057qib7 11254 3 this this DT cord-005453-4057qib7 11254 4 schedule schedule NN cord-005453-4057qib7 11254 5 is be VBZ cord-005453-4057qib7 11254 6 associated associate VBN cord-005453-4057qib7 11254 7 with with IN cord-005453-4057qib7 11254 8 a a DT cord-005453-4057qib7 11254 9 high high JJ cord-005453-4057qib7 11254 10 cost cost NN cord-005453-4057qib7 11254 11 and and CC cord-005453-4057qib7 11254 12 significant significant JJ cord-005453-4057qib7 11254 13 toxicity toxicity NN cord-005453-4057qib7 11254 14 particularly particularly RB cord-005453-4057qib7 11254 15 in in IN cord-005453-4057qib7 11254 16 term term NN cord-005453-4057qib7 11254 17 of of IN cord-005453-4057qib7 11254 18 peripheral peripheral JJ cord-005453-4057qib7 11254 19 neuropathy neuropathy NN cord-005453-4057qib7 11254 20 . . . cord-005453-4057qib7 11255 1 Our -PRON- PRP$ cord-005453-4057qib7 11255 2 primary primary JJ cord-005453-4057qib7 11255 3 objective objective NN cord-005453-4057qib7 11255 4 is be VBZ cord-005453-4057qib7 11255 5 to to TO cord-005453-4057qib7 11255 6 assess assess VB cord-005453-4057qib7 11255 7 the the DT cord-005453-4057qib7 11255 8 efficacy efficacy NN cord-005453-4057qib7 11255 9 of of IN cord-005453-4057qib7 11255 10 4 4 CD cord-005453-4057qib7 11255 11 cycles cycle NNS cord-005453-4057qib7 11255 12 Brentuximab Brentuximab NNP cord-005453-4057qib7 11255 13 as as IN cord-005453-4057qib7 11255 14 consolidation consolidation NN cord-005453-4057qib7 11255 15 therapy therapy NN cord-005453-4057qib7 11255 16 after after IN cord-005453-4057qib7 11255 17 ASCT ASCT NNP cord-005453-4057qib7 11255 18 for for IN cord-005453-4057qib7 11255 19 relapsed relapse VBN cord-005453-4057qib7 11255 20 / / SYM cord-005453-4057qib7 11255 21 refractory refractory NN cord-005453-4057qib7 11255 22 ( ( -LRB- cord-005453-4057qib7 11255 23 R r NN cord-005453-4057qib7 11255 24 / / SYM cord-005453-4057qib7 11255 25 R r NN cord-005453-4057qib7 11255 26 ) ) -RRB- cord-005453-4057qib7 11255 27 HL HL NNP cord-005453-4057qib7 11255 28 . . . cord-005453-4057qib7 11256 1 Secondary secondary JJ cord-005453-4057qib7 11256 2 objectives objective NNS cord-005453-4057qib7 11256 3 include include VBP cord-005453-4057qib7 11256 4 side side NN cord-005453-4057qib7 11256 5 effects effect NNS cord-005453-4057qib7 11256 6 , , , cord-005453-4057qib7 11256 7 progression progression NN cord-005453-4057qib7 11256 8 free free JJ cord-005453-4057qib7 11256 9 survival survival NN cord-005453-4057qib7 11256 10 ( ( -LRB- cord-005453-4057qib7 11256 11 PFS PFS NNP cord-005453-4057qib7 11256 12 ) ) -RRB- cord-005453-4057qib7 11256 13 , , , cord-005453-4057qib7 11256 14 and and CC cord-005453-4057qib7 11256 15 overall overall JJ cord-005453-4057qib7 11256 16 Survival Survival NNP cord-005453-4057qib7 11256 17 ( ( -LRB- cord-005453-4057qib7 11256 18 OS OS NNP cord-005453-4057qib7 11256 19 ) ) -RRB- cord-005453-4057qib7 11256 20 . . . cord-005453-4057qib7 11257 1 Methods method NNS cord-005453-4057qib7 11257 2 : : : cord-005453-4057qib7 11257 3 This this DT cord-005453-4057qib7 11257 4 is be VBZ cord-005453-4057qib7 11257 5 a a DT cord-005453-4057qib7 11257 6 retrospective retrospective JJ cord-005453-4057qib7 11257 7 single single JJ cord-005453-4057qib7 11257 8 center center NN cord-005453-4057qib7 11257 9 analysis analysis NN cord-005453-4057qib7 11257 10 approved approve VBN cord-005453-4057qib7 11257 11 by by IN cord-005453-4057qib7 11257 12 the the DT cord-005453-4057qib7 11257 13 IRB IRB NNP cord-005453-4057qib7 11257 14 of of IN cord-005453-4057qib7 11257 15 the the DT cord-005453-4057qib7 11257 16 American American NNP cord-005453-4057qib7 11257 17 University University NNP cord-005453-4057qib7 11257 18 of of IN cord-005453-4057qib7 11257 19 Beirut Beirut NNP cord-005453-4057qib7 11257 20 Medical Medical NNP cord-005453-4057qib7 11257 21 Center Center NNP cord-005453-4057qib7 11257 22 . . . cord-005453-4057qib7 11258 1 We -PRON- PRP cord-005453-4057qib7 11258 2 included include VBD cord-005453-4057qib7 11258 3 in in IN cord-005453-4057qib7 11258 4 this this DT cord-005453-4057qib7 11258 5 study study NN cord-005453-4057qib7 11258 6 consecutive consecutive JJ cord-005453-4057qib7 11258 7 patients patient NNS cord-005453-4057qib7 11258 8 with with IN cord-005453-4057qib7 11258 9 R r NN cord-005453-4057qib7 11258 10 / / SYM cord-005453-4057qib7 11258 11 R r NN cord-005453-4057qib7 11258 12 HL HL NNP cord-005453-4057qib7 11258 13 who who WP cord-005453-4057qib7 11258 14 underwent undergo VBD cord-005453-4057qib7 11258 15 ASCT ASCT NNP cord-005453-4057qib7 11258 16 between between IN cord-005453-4057qib7 11258 17 2014 2014 CD cord-005453-4057qib7 11258 18 and and CC cord-005453-4057qib7 11258 19 2018 2018 CD cord-005453-4057qib7 11258 20 , , , cord-005453-4057qib7 11258 21 and and CC cord-005453-4057qib7 11258 22 received receive VBD cord-005453-4057qib7 11258 23 BV BV NNP cord-005453-4057qib7 11258 24 consolidation consolidation NN cord-005453-4057qib7 11258 25 post post NN cord-005453-4057qib7 11258 26 - - JJ cord-005453-4057qib7 11258 27 ASCT ASCT NNP cord-005453-4057qib7 11258 28 . . . cord-005453-4057qib7 11259 1 Results result NNS cord-005453-4057qib7 11259 2 : : : cord-005453-4057qib7 11260 1 We -PRON- PRP cord-005453-4057qib7 11260 2 identified identify VBD cord-005453-4057qib7 11260 3 18 18 CD cord-005453-4057qib7 11260 4 consecutive consecutive JJ cord-005453-4057qib7 11260 5 adult adult NN cord-005453-4057qib7 11260 6 patients patient NNS cord-005453-4057qib7 11260 7 with with IN cord-005453-4057qib7 11260 8 R r NN cord-005453-4057qib7 11260 9 / / SYM cord-005453-4057qib7 11260 10 R r NN cord-005453-4057qib7 11260 11 HL HL NNP cord-005453-4057qib7 11260 12 treated treat VBN cord-005453-4057qib7 11260 13 with with IN cord-005453-4057qib7 11260 14 BV BV NNP cord-005453-4057qib7 11260 15 1.8 1.8 CD cord-005453-4057qib7 11260 16 mg mg CD cord-005453-4057qib7 11261 1 /kg /kg NFP cord-005453-4057qib7 11261 2 IV IV NNP cord-005453-4057qib7 11262 1 every every DT cord-005453-4057qib7 11262 2 3 3 CD cord-005453-4057qib7 11262 3 weeks week NNS cord-005453-4057qib7 11262 4 as as IN cord-005453-4057qib7 11262 5 consolidation consolidation NN cord-005453-4057qib7 11262 6 therapy therapy NN cord-005453-4057qib7 11262 7 after after IN cord-005453-4057qib7 11262 8 ASCT ASCT NNP cord-005453-4057qib7 11262 9 . . . cord-005453-4057qib7 11263 1 The the DT cord-005453-4057qib7 11263 2 indications indication NNS cord-005453-4057qib7 11263 3 for for IN cord-005453-4057qib7 11263 4 BV BV NNP cord-005453-4057qib7 11263 5 consolidation consolidation NN cord-005453-4057qib7 11263 6 was be VBD cord-005453-4057qib7 11263 7 primary primary JJ cord-005453-4057qib7 11263 8 refractory refractory JJ cord-005453-4057qib7 11263 9 disease disease NN cord-005453-4057qib7 11263 10 in in IN cord-005453-4057qib7 11263 11 11 11 CD cord-005453-4057qib7 11263 12 patients patient NNS cord-005453-4057qib7 11263 13 ( ( -LRB- cord-005453-4057qib7 11263 14 61 61 CD cord-005453-4057qib7 11263 15 % % NN cord-005453-4057qib7 11263 16 ) ) -RRB- cord-005453-4057qib7 11263 17 , , , cord-005453-4057qib7 11263 18 early early JJ cord-005453-4057qib7 11263 19 relapse relapse NN cord-005453-4057qib7 11263 20 in in IN cord-005453-4057qib7 11263 21 6 6 CD cord-005453-4057qib7 11263 22 patients patient NNS cord-005453-4057qib7 11263 23 ( ( -LRB- cord-005453-4057qib7 11263 24 33 33 CD cord-005453-4057qib7 11263 25 % % NN cord-005453-4057qib7 11263 26 ) ) -RRB- cord-005453-4057qib7 11263 27 ( ( -LRB- cord-005453-4057qib7 11263 28 after after IN cord-005453-4057qib7 11263 29 a a DT cord-005453-4057qib7 11263 30 median median JJ cord-005453-4057qib7 11263 31 time time NN cord-005453-4057qib7 11263 32 of of IN cord-005453-4057qib7 11263 33 10 10 CD cord-005453-4057qib7 11263 34 months month NNS cord-005453-4057qib7 11263 35 ; ; : cord-005453-4057qib7 11263 36 range range NN cord-005453-4057qib7 11263 37 , , , cord-005453-4057qib7 11263 38 3 3 CD cord-005453-4057qib7 11263 39 - - SYM cord-005453-4057qib7 11263 40 11 11 CD cord-005453-4057qib7 11263 41 ) ) -RRB- cord-005453-4057qib7 11263 42 andextranodalinvolvement andextranodalinvolvement VBP cord-005453-4057qib7 11263 43 in in IN cord-005453-4057qib7 11263 44 one one CD cord-005453-4057qib7 11263 45 patient patient NN cord-005453-4057qib7 11263 46 ( ( -LRB- cord-005453-4057qib7 11263 47 6 6 CD cord-005453-4057qib7 11263 48 % % NN cord-005453-4057qib7 11263 49 ) ) -RRB- cord-005453-4057qib7 11263 50 . . . cord-005453-4057qib7 11264 1 The the DT cord-005453-4057qib7 11264 2 median median JJ cord-005453-4057qib7 11264 3 number number NN cord-005453-4057qib7 11264 4 of of IN cord-005453-4057qib7 11264 5 lines line NNS cord-005453-4057qib7 11264 6 of of IN cord-005453-4057qib7 11264 7 therapy therapy NN cord-005453-4057qib7 11264 8 pre pre JJ cord-005453-4057qib7 11264 9 - - NNP cord-005453-4057qib7 11264 10 ASCT ASCT NNP cord-005453-4057qib7 11264 11 was be VBD cord-005453-4057qib7 11264 12 3 3 CD cord-005453-4057qib7 11265 1 ( ( -LRB- cord-005453-4057qib7 11265 2 range range NN cord-005453-4057qib7 11265 3 , , , cord-005453-4057qib7 11265 4 2 2 CD cord-005453-4057qib7 11265 5 - - SYM cord-005453-4057qib7 11265 6 5 5 CD cord-005453-4057qib7 11265 7 ) ) -RRB- cord-005453-4057qib7 11265 8 . . . cord-005453-4057qib7 11266 1 The the DT cord-005453-4057qib7 11266 2 median median JJ cord-005453-4057qib7 11266 3 time time NN cord-005453-4057qib7 11266 4 to to IN cord-005453-4057qib7 11266 5 BV BV NNP cord-005453-4057qib7 11266 6 initiation initiation NN cord-005453-4057qib7 11266 7 post post JJ cord-005453-4057qib7 11266 8 - - JJ cord-005453-4057qib7 11266 9 ASCT ASCT NNP cord-005453-4057qib7 11266 10 was be VBD cord-005453-4057qib7 11266 11 76 76 CD cord-005453-4057qib7 11266 12 days day NNS cord-005453-4057qib7 11266 13 ( ( -LRB- cord-005453-4057qib7 11266 14 range range NN cord-005453-4057qib7 11266 15 , , , cord-005453-4057qib7 11266 16 35 35 CD cord-005453-4057qib7 11266 17 - - SYM cord-005453-4057qib7 11266 18 188 188 CD cord-005453-4057qib7 11266 19 ) ) -RRB- cord-005453-4057qib7 11266 20 . . . cord-005453-4057qib7 11267 1 Patients patient NNS cord-005453-4057qib7 11267 2 received receive VBD cord-005453-4057qib7 11267 3 a a DT cord-005453-4057qib7 11267 4 median median NN cord-005453-4057qib7 11267 5 of of IN cord-005453-4057qib7 11267 6 4 4 CD cord-005453-4057qib7 11267 7 cycles cycle NNS cord-005453-4057qib7 11267 8 ( ( -LRB- cord-005453-4057qib7 11267 9 range range VBP cord-005453-4057qib7 11267 10 , , , cord-005453-4057qib7 11267 11 3 3 CD cord-005453-4057qib7 11267 12 - - SYM cord-005453-4057qib7 11267 13 4 4 CD cord-005453-4057qib7 11267 14 ) ) -RRB- cord-005453-4057qib7 11267 15 of of IN cord-005453-4057qib7 11267 16 BV BV NNP cord-005453-4057qib7 11267 17 post post NNP cord-005453-4057qib7 11267 18 - - JJ cord-005453-4057qib7 11267 19 ASCT ASCT NNP cord-005453-4057qib7 11267 20 . . . cord-005453-4057qib7 11268 1 After after IN cord-005453-4057qib7 11268 2 a a DT cord-005453-4057qib7 11268 3 median median NN cord-005453-4057qib7 11268 4 follow follow NN cord-005453-4057qib7 11268 5 up up IN cord-005453-4057qib7 11268 6 of of IN cord-005453-4057qib7 11268 7 30 30 CD cord-005453-4057qib7 11268 8 months month NNS cord-005453-4057qib7 11268 9 ( ( -LRB- cord-005453-4057qib7 11268 10 range range NN cord-005453-4057qib7 11268 11 , , , cord-005453-4057qib7 11268 12 8 8 CD cord-005453-4057qib7 11268 13 - - SYM cord-005453-4057qib7 11268 14 50 50 CD cord-005453-4057qib7 11268 15 ) ) -RRB- cord-005453-4057qib7 11268 16 , , , cord-005453-4057qib7 11268 17 five five CD cord-005453-4057qib7 11268 18 ( ( -LRB- cord-005453-4057qib7 11268 19 28 28 CD cord-005453-4057qib7 11268 20 % % NN cord-005453-4057qib7 11268 21 ) ) -RRB- cord-005453-4057qib7 11268 22 patients patient NNS cord-005453-4057qib7 11268 23 relapsed relapse VBN cord-005453-4057qib7 11268 24 after after IN cord-005453-4057qib7 11268 25 ASCT ASCT NNP cord-005453-4057qib7 11268 26 . . . cord-005453-4057qib7 11269 1 The the DT cord-005453-4057qib7 11269 2 median median JJ cord-005453-4057qib7 11269 3 time time NN cord-005453-4057qib7 11269 4 to to TO cord-005453-4057qib7 11269 5 relapse relapse NN cord-005453-4057qib7 11269 6 was be VBD cord-005453-4057qib7 11269 7 7 7 CD cord-005453-4057qib7 11269 8 months month NNS cord-005453-4057qib7 11269 9 ( ( -LRB- cord-005453-4057qib7 11269 10 range range NN cord-005453-4057qib7 11269 11 , , , cord-005453-4057qib7 11269 12 4 4 CD cord-005453-4057qib7 11269 13 - - SYM cord-005453-4057qib7 11269 14 21 21 CD cord-005453-4057qib7 11269 15 ) ) -RRB- cord-005453-4057qib7 11269 16 . . . cord-005453-4057qib7 11270 1 Median median JJ cord-005453-4057qib7 11270 2 PFS PFS NNP cord-005453-4057qib7 11270 3 and and CC cord-005453-4057qib7 11270 4 OS OS NNP cord-005453-4057qib7 11270 5 were be VBD cord-005453-4057qib7 11270 6 not not RB cord-005453-4057qib7 11270 7 reached reach VBN cord-005453-4057qib7 11270 8 . . . cord-005453-4057qib7 11271 1 We -PRON- PRP cord-005453-4057qib7 11271 2 did do VBD cord-005453-4057qib7 11271 3 not not RB cord-005453-4057qib7 11271 4 observe observe VB cord-005453-4057qib7 11271 5 any any DT cord-005453-4057qib7 11271 6 significant significant JJ cord-005453-4057qib7 11271 7 toxicities toxicity NNS cord-005453-4057qib7 11271 8 during during IN cord-005453-4057qib7 11271 9 or or CC cord-005453-4057qib7 11271 10 after after IN cord-005453-4057qib7 11271 11 therapy therapy NN cord-005453-4057qib7 11271 12 . . . cord-005453-4057qib7 11272 1 Conclusions conclusion NNS cord-005453-4057qib7 11272 2 : : : cord-005453-4057qib7 11272 3 4 4 CD cord-005453-4057qib7 11272 4 cycles cycle NNS cord-005453-4057qib7 11272 5 of of IN cord-005453-4057qib7 11272 6 BV BV NNP cord-005453-4057qib7 11272 7 consolidation consolidation NN cord-005453-4057qib7 11272 8 after after IN cord-005453-4057qib7 11272 9 ASCT ASCT NNP cord-005453-4057qib7 11272 10 seem seem VBP cord-005453-4057qib7 11272 11 to to TO cord-005453-4057qib7 11272 12 be be VB cord-005453-4057qib7 11272 13 safe safe JJ cord-005453-4057qib7 11272 14 and and CC cord-005453-4057qib7 11272 15 effective effective JJ cord-005453-4057qib7 11272 16 in in IN cord-005453-4057qib7 11272 17 preventing prevent VBG cord-005453-4057qib7 11272 18 relapse relapse NN cord-005453-4057qib7 11273 1 , , , cord-005453-4057qib7 11273 2 however however RB cord-005453-4057qib7 11273 3 our -PRON- PRP$ cord-005453-4057qib7 11273 4 findings finding NNS cord-005453-4057qib7 11273 5 need need VBP cord-005453-4057qib7 11273 6 to to TO cord-005453-4057qib7 11273 7 be be VB cord-005453-4057qib7 11273 8 confirmed confirm VBN cord-005453-4057qib7 11273 9 with with IN cord-005453-4057qib7 11273 10 larger large JJR cord-005453-4057qib7 11273 11 prospective prospective JJ cord-005453-4057qib7 11273 12 studies study NNS cord-005453-4057qib7 11273 13 . . . cord-005453-4057qib7 11274 1 chemotherapy chemotherapy NN cord-005453-4057qib7 11274 2 or or CC cord-005453-4057qib7 11274 3 who who WP cord-005453-4057qib7 11274 4 progress progress VBP cord-005453-4057qib7 11274 5 after after IN cord-005453-4057qib7 11274 6 autoHSCT autoHSCT NNP cord-005453-4057qib7 11274 7 is be VBZ cord-005453-4057qib7 11274 8 poor poor JJ cord-005453-4057qib7 11274 9 . . . cord-005453-4057qib7 11275 1 Despite despite IN cord-005453-4057qib7 11275 2 introduction introduction NN cord-005453-4057qib7 11275 3 of of IN cord-005453-4057qib7 11275 4 novel novel JJ cord-005453-4057qib7 11275 5 agents agent NNS cord-005453-4057qib7 11275 6 like like IN cord-005453-4057qib7 11275 7 brentuximab brentuximab NNP cord-005453-4057qib7 11275 8 vedotin vedotin NNP cord-005453-4057qib7 11275 9 ( ( -LRB- cord-005453-4057qib7 11275 10 BV BV NNP cord-005453-4057qib7 11275 11 ) ) -RRB- cord-005453-4057qib7 11275 12 or or CC cord-005453-4057qib7 11275 13 nivolumab nivolumab NNP cord-005453-4057qib7 11275 14 , , , cord-005453-4057qib7 11275 15 alloHSCT alloHSCT NNP cord-005453-4057qib7 11275 16 appears appear VBZ cord-005453-4057qib7 11275 17 the the DT cord-005453-4057qib7 11275 18 most most RBS cord-005453-4057qib7 11275 19 effective effective JJ cord-005453-4057qib7 11275 20 treatment treatment NN cord-005453-4057qib7 11275 21 option option NN cord-005453-4057qib7 11275 22 with with IN cord-005453-4057qib7 11275 23 curative curative JJ cord-005453-4057qib7 11275 24 potential potential NN cord-005453-4057qib7 11275 25 . . . cord-005453-4057qib7 11276 1 The the DT cord-005453-4057qib7 11276 2 goal goal NN cord-005453-4057qib7 11276 3 of of IN cord-005453-4057qib7 11276 4 this this DT cord-005453-4057qib7 11276 5 study study NN cord-005453-4057qib7 11276 6 was be VBD cord-005453-4057qib7 11276 7 to to TO cord-005453-4057qib7 11276 8 evaluate evaluate VB cord-005453-4057qib7 11276 9 efficacy efficacy NN cord-005453-4057qib7 11276 10 of of IN cord-005453-4057qib7 11276 11 alloHSCT allohsct NN cord-005453-4057qib7 11276 12 for for IN cord-005453-4057qib7 11276 13 HL HL NNP cord-005453-4057qib7 11276 14 , , , cord-005453-4057qib7 11276 15 including include VBG cord-005453-4057qib7 11276 16 patients patient NNS cord-005453-4057qib7 11276 17 pre pre VB cord-005453-4057qib7 11276 18 - - VBN cord-005453-4057qib7 11276 19 treated treat VBN cord-005453-4057qib7 11276 20 with with IN cord-005453-4057qib7 11276 21 novel novel JJ cord-005453-4057qib7 11276 22 agents agent NNS cord-005453-4057qib7 11276 23 . . . cord-005453-4057qib7 11277 1 Methods method NNS cord-005453-4057qib7 11277 2 : : : cord-005453-4057qib7 11278 1 Between between IN cord-005453-4057qib7 11278 2 years year NNS cord-005453-4057qib7 11278 3 2012 2012 CD cord-005453-4057qib7 11278 4 - - SYM cord-005453-4057qib7 11278 5 2018 2018 CD cord-005453-4057qib7 11278 6 , , , cord-005453-4057qib7 11278 7 45 45 CD cord-005453-4057qib7 11278 8 patients patient NNS cord-005453-4057qib7 11278 9 ( ( -LRB- cord-005453-4057qib7 11278 10 including include VBG cord-005453-4057qib7 11278 11 23 23 CD cord-005453-4057qib7 11278 12 males male NNS cord-005453-4057qib7 11278 13 ) ) -RRB- cord-005453-4057qib7 11278 14 with with IN cord-005453-4057qib7 11278 15 HL HL NNP cord-005453-4057qib7 11278 16 were be VBD cord-005453-4057qib7 11278 17 treated treat VBN cord-005453-4057qib7 11278 18 with with IN cord-005453-4057qib7 11278 19 alloHSCT alloHSCT NNP cord-005453-4057qib7 11278 20 in in IN cord-005453-4057qib7 11278 21 MSC MSC NNP cord-005453-4057qib7 11278 22 Institute Institute NNP cord-005453-4057qib7 11278 23 of of IN cord-005453-4057qib7 11278 24 Oncology Oncology NNP cord-005453-4057qib7 11278 25 in in IN cord-005453-4057qib7 11278 26 Gliwice Gliwice NNP cord-005453-4057qib7 11278 27 , , , cord-005453-4057qib7 11278 28 Poland Poland NNP cord-005453-4057qib7 11278 29 . . . cord-005453-4057qib7 11279 1 Median median JJ cord-005453-4057qib7 11279 2 age age NN cord-005453-4057qib7 11279 3 was be VBD cord-005453-4057qib7 11279 4 32 32 CD cord-005453-4057qib7 11279 5 ( ( -LRB- cord-005453-4057qib7 11279 6 19 19 CD cord-005453-4057qib7 11279 7 - - SYM cord-005453-4057qib7 11279 8 57 57 CD cord-005453-4057qib7 11279 9 ) ) -RRB- cord-005453-4057qib7 11279 10 years year NNS cord-005453-4057qib7 11279 11 . . . cord-005453-4057qib7 11280 1 Median median JJ cord-005453-4057qib7 11280 2 lines line NNS cord-005453-4057qib7 11280 3 of of IN cord-005453-4057qib7 11280 4 preceding precede VBG cord-005453-4057qib7 11280 5 chemotherapy chemotherapy NN cord-005453-4057qib7 11280 6 was be VBD cord-005453-4057qib7 11280 7 4 4 CD cord-005453-4057qib7 11280 8 ( ( -LRB- cord-005453-4057qib7 11280 9 2 2 CD cord-005453-4057qib7 11280 10 - - SYM cord-005453-4057qib7 11280 11 8 8 CD cord-005453-4057qib7 11280 12 ) ) -RRB- cord-005453-4057qib7 11280 13 ; ; : cord-005453-4057qib7 11281 1 34 34 CD cord-005453-4057qib7 11281 2 ( ( -LRB- cord-005453-4057qib7 11281 3 76 76 CD cord-005453-4057qib7 11281 4 % % NN cord-005453-4057qib7 11281 5 ) ) -RRB- cord-005453-4057qib7 11281 6 patients patient NNS cord-005453-4057qib7 11281 7 had have VBD cord-005453-4057qib7 11281 8 been be VBN cord-005453-4057qib7 11281 9 pre pre VBN cord-005453-4057qib7 11281 10 - - VBN cord-005453-4057qib7 11281 11 treated treat VBN cord-005453-4057qib7 11282 1 with with IN cord-005453-4057qib7 11282 2 autoHSCT autoHSCT NNP cord-005453-4057qib7 11282 3 , , , cord-005453-4057qib7 11282 4 24 24 CD cord-005453-4057qib7 11282 5 ( ( -LRB- cord-005453-4057qib7 11282 6 53 53 CD cord-005453-4057qib7 11282 7 % % NN cord-005453-4057qib7 11282 8 ) ) -RRB- cord-005453-4057qib7 11282 9 with with IN cord-005453-4057qib7 11282 10 radiotherapy radiotherapy NN cord-005453-4057qib7 11282 11 , , , cord-005453-4057qib7 11282 12 17 17 CD cord-005453-4057qib7 11282 13 ( ( -LRB- cord-005453-4057qib7 11282 14 38 38 CD cord-005453-4057qib7 11282 15 % % NN cord-005453-4057qib7 11282 16 ) ) -RRB- cord-005453-4057qib7 11282 17 with with IN cord-005453-4057qib7 11282 18 BV BV NNP cord-005453-4057qib7 11282 19 , , , cord-005453-4057qib7 11282 20 7 7 CD cord-005453-4057qib7 11282 21 ( ( -LRB- cord-005453-4057qib7 11282 22 16 16 CD cord-005453-4057qib7 11282 23 % % NN cord-005453-4057qib7 11282 24 ) ) -RRB- cord-005453-4057qib7 11283 1 -with -with HYPH cord-005453-4057qib7 11283 2 nivolumab nivolumab NNP cord-005453-4057qib7 11283 3 . . . cord-005453-4057qib7 11284 1 Disease disease NN cord-005453-4057qib7 11284 2 status status NN cord-005453-4057qib7 11284 3 at at IN cord-005453-4057qib7 11284 4 alloHSCT alloHSCT NNP cord-005453-4057qib7 11284 5 was be VBD cord-005453-4057qib7 11284 6 as as IN cord-005453-4057qib7 11284 7 follows follow VBZ cord-005453-4057qib7 11284 8 : : : cord-005453-4057qib7 11284 9 CR-19 CR-19 NNP cord-005453-4057qib7 11284 10 , , , cord-005453-4057qib7 11284 11 PR-10 PR-10 NNP cord-005453-4057qib7 11284 12 , , , cord-005453-4057qib7 11284 13 NR-16 NR-16 NNP cord-005453-4057qib7 11284 14 . . . cord-005453-4057qib7 11285 1 Patients patient NNS cord-005453-4057qib7 11285 2 were be VBD cord-005453-4057qib7 11285 3 treated treat VBN cord-005453-4057qib7 11285 4 with with IN cord-005453-4057qib7 11285 5 HSCT HSCT NNP cord-005453-4057qib7 11285 6 from from IN cord-005453-4057qib7 11285 7 either either DT cord-005453-4057qib7 11285 8 HLA HLA NNP cord-005453-4057qib7 11285 9 - - HYPH cord-005453-4057qib7 11285 10 matched match VBN cord-005453-4057qib7 11285 11 sibling sibling NN cord-005453-4057qib7 11285 12 donor donor NN cord-005453-4057qib7 11285 13 ( ( -LRB- cord-005453-4057qib7 11285 14 MSD MSD NNP cord-005453-4057qib7 11285 15 , , , cord-005453-4057qib7 11285 16 n=21 n=21 NN cord-005453-4057qib7 11285 17 ) ) -RRB- cord-005453-4057qib7 11285 18 , , , cord-005453-4057qib7 11285 19 unrelated unrelated JJ cord-005453-4057qib7 11285 20 donor donor NN cord-005453-4057qib7 11285 21 ( ( -LRB- cord-005453-4057qib7 11285 22 URD URD NNP cord-005453-4057qib7 11285 23 , , , cord-005453-4057qib7 11285 24 n=18 n=18 NN cord-005453-4057qib7 11285 25 ) ) -RRB- cord-005453-4057qib7 11285 26 or or CC cord-005453-4057qib7 11285 27 haploidentical haploidentical JJ cord-005453-4057qib7 11285 28 donor donor NN cord-005453-4057qib7 11285 29 ( ( -LRB- cord-005453-4057qib7 11285 30 n=6 n=6 NNP cord-005453-4057qib7 11285 31 ) ) -RRB- cord-005453-4057qib7 11285 32 . . . cord-005453-4057qib7 11286 1 Conditioning conditioning NN cord-005453-4057qib7 11286 2 was be VBD cord-005453-4057qib7 11286 3 myeloablative myeloablative JJ cord-005453-4057qib7 11286 4 in in IN cord-005453-4057qib7 11286 5 21 21 CD cord-005453-4057qib7 11286 6 ( ( -LRB- cord-005453-4057qib7 11286 7 47 47 CD cord-005453-4057qib7 11286 8 % % NN cord-005453-4057qib7 11286 9 ) ) -RRB- cord-005453-4057qib7 11286 10 cases case NNS cord-005453-4057qib7 11286 11 . . . cord-005453-4057qib7 11287 1 Peripheral peripheral JJ cord-005453-4057qib7 11287 2 blood blood NN cord-005453-4057qib7 11287 3 was be VBD cord-005453-4057qib7 11287 4 used use VBN cord-005453-4057qib7 11287 5 as as IN cord-005453-4057qib7 11287 6 a a DT cord-005453-4057qib7 11287 7 source source NN cord-005453-4057qib7 11287 8 of of IN cord-005453-4057qib7 11287 9 stem stem NN cord-005453-4057qib7 11287 10 cells cell NNS cord-005453-4057qib7 11287 11 . . . cord-005453-4057qib7 11288 1 Results result NNS cord-005453-4057qib7 11288 2 : : : cord-005453-4057qib7 11289 1 All all DT cord-005453-4057qib7 11289 2 but but IN cord-005453-4057qib7 11289 3 one one CD cord-005453-4057qib7 11289 4 patient patient NN cord-005453-4057qib7 11289 5 engrafted engraft VBN cord-005453-4057qib7 11289 6 with with IN cord-005453-4057qib7 11289 7 median median JJ cord-005453-4057qib7 11289 8 time time NN cord-005453-4057qib7 11289 9 of of IN cord-005453-4057qib7 11289 10 neutrophil neutrophil NN cord-005453-4057qib7 11289 11 recovery recovery NN cord-005453-4057qib7 11289 12 of of IN cord-005453-4057qib7 11289 13 14 14 CD cord-005453-4057qib7 11289 14 ( ( -LRB- cord-005453-4057qib7 11289 15 9 9 CD cord-005453-4057qib7 11289 16 - - SYM cord-005453-4057qib7 11289 17 20 20 CD cord-005453-4057qib7 11289 18 ) ) -RRB- cord-005453-4057qib7 11289 19 days day NNS cord-005453-4057qib7 11289 20 . . . cord-005453-4057qib7 11290 1 The the DT cord-005453-4057qib7 11290 2 incidence incidence NN cord-005453-4057qib7 11290 3 of of IN cord-005453-4057qib7 11290 4 grade grade NN cord-005453-4057qib7 11290 5 2 2 CD cord-005453-4057qib7 11290 6 - - SYM cord-005453-4057qib7 11290 7 4 4 CD cord-005453-4057qib7 11290 8 and and CC cord-005453-4057qib7 11290 9 grade grade NN cord-005453-4057qib7 11290 10 3 3 CD cord-005453-4057qib7 11290 11 - - SYM cord-005453-4057qib7 11290 12 4 4 CD cord-005453-4057qib7 11290 13 acute acute JJ cord-005453-4057qib7 11290 14 GVHD GVHD NNP cord-005453-4057qib7 11290 15 was be VBD cord-005453-4057qib7 11290 16 16 16 CD cord-005453-4057qib7 11290 17 % % NN cord-005453-4057qib7 11290 18 and and CC cord-005453-4057qib7 11290 19 11 11 CD cord-005453-4057qib7 11290 20 % % NN cord-005453-4057qib7 11290 21 , , , cord-005453-4057qib7 11290 22 respectively respectively RB cord-005453-4057qib7 11290 23 , , , cord-005453-4057qib7 11290 24 while while IN cord-005453-4057qib7 11290 25 the the DT cord-005453-4057qib7 11290 26 incidence incidence NN cord-005453-4057qib7 11290 27 of of IN cord-005453-4057qib7 11290 28 chronic chronic JJ cord-005453-4057qib7 11290 29 GvHD gvhd NN cord-005453-4057qib7 11290 30 was be VBD cord-005453-4057qib7 11290 31 43 43 CD cord-005453-4057qib7 11290 32 % % NN cord-005453-4057qib7 11290 33 . . . cord-005453-4057qib7 11291 1 The the DT cord-005453-4057qib7 11291 2 probabilities probability NNS cord-005453-4057qib7 11291 3 of of IN cord-005453-4057qib7 11291 4 OS OS NNP cord-005453-4057qib7 11291 5 and and CC cord-005453-4057qib7 11291 6 PFS PFS NNP cord-005453-4057qib7 11291 7 at at IN cord-005453-4057qib7 11291 8 2 2 CD cord-005453-4057qib7 11291 9 years year NNS cord-005453-4057qib7 11291 10 were be VBD cord-005453-4057qib7 11291 11 54 54 CD cord-005453-4057qib7 11291 12 % % NN cord-005453-4057qib7 11291 13 ( ( -LRB- cord-005453-4057qib7 11291 14 + + CC cord-005453-4057qib7 11291 15 /-12 /-12 . cord-005453-4057qib7 11291 16 % % NN cord-005453-4057qib7 11291 17 ) ) -RRB- cord-005453-4057qib7 11291 18 and and CC cord-005453-4057qib7 11291 19 55 55 CD cord-005453-4057qib7 11291 20 % % NN cord-005453-4057qib7 11291 21 ( ( -LRB- cord-005453-4057qib7 11291 22 + + CC cord-005453-4057qib7 11291 23 /-8 /-8 CD cord-005453-4057qib7 11291 24 % % NN cord-005453-4057qib7 11291 25 ) ) -RRB- cord-005453-4057qib7 11291 26 , , , cord-005453-4057qib7 11291 27 respectively respectively RB cord-005453-4057qib7 11291 28 . . . cord-005453-4057qib7 11292 1 The the DT cord-005453-4057qib7 11292 2 incidences incidence NNS cord-005453-4057qib7 11292 3 of of IN cord-005453-4057qib7 11292 4 progression progression NN cord-005453-4057qib7 11292 5 and and CC cord-005453-4057qib7 11292 6 transplant transplant NN cord-005453-4057qib7 11292 7 - - HYPH cord-005453-4057qib7 11292 8 related relate VBN cord-005453-4057qib7 11292 9 mortality mortality NN cord-005453-4057qib7 11292 10 were be VBD cord-005453-4057qib7 11292 11 31 31 CD cord-005453-4057qib7 11292 12 % % NN cord-005453-4057qib7 11292 13 and and CC cord-005453-4057qib7 11292 14 14 14 CD cord-005453-4057qib7 11292 15 % % NN cord-005453-4057qib7 11292 16 , , , cord-005453-4057qib7 11292 17 respectively respectively RB cord-005453-4057qib7 11292 18 . . . cord-005453-4057qib7 11293 1 The the DT cord-005453-4057qib7 11293 2 2y 2y CD cord-005453-4057qib7 11293 3 PFS PFS NNP cord-005453-4057qib7 11293 4 rates rate NNS cord-005453-4057qib7 11293 5 were be VBD cord-005453-4057qib7 11293 6 42 42 CD cord-005453-4057qib7 11293 7 % % NN cord-005453-4057qib7 11293 8 for for IN cord-005453-4057qib7 11293 9 MSD MSD NNP cord-005453-4057qib7 11293 10 , , , cord-005453-4057qib7 11293 11 72 72 CD cord-005453-4057qib7 11293 12 % % NN cord-005453-4057qib7 11293 13 for for IN cord-005453-4057qib7 11293 14 URD URD NNP cord-005453-4057qib7 11293 15 and and CC cord-005453-4057qib7 11293 16 62 62 CD cord-005453-4057qib7 11293 17 % % NN cord-005453-4057qib7 11293 18 for for IN cord-005453-4057qib7 11293 19 haploidentical haploidentical JJ cord-005453-4057qib7 11293 20 donors donor NNS cord-005453-4057qib7 11293 21 . . . cord-005453-4057qib7 11294 1 In in IN cord-005453-4057qib7 11294 2 a a DT cord-005453-4057qib7 11294 3 univariate univariate JJ cord-005453-4057qib7 11294 4 analysis analysis NN cord-005453-4057qib7 11294 5 PFS PFS NNP cord-005453-4057qib7 11294 6 was be VBD cord-005453-4057qib7 11294 7 affected affect VBN cord-005453-4057qib7 11294 8 by by IN cord-005453-4057qib7 11294 9 recipient recipient NN cord-005453-4057qib7 11294 10 gender gender NN cord-005453-4057qib7 11294 11 ( ( -LRB- cord-005453-4057qib7 11294 12 female female JJ cord-005453-4057qib7 11294 13 -75 -75 CD cord-005453-4057qib7 11294 14 % % NN cord-005453-4057qib7 11294 15 , , , cord-005453-4057qib7 11294 16 male male JJ cord-005453-4057qib7 11294 17 -38 -38 NNP cord-005453-4057qib7 11294 18 % % NN cord-005453-4057qib7 11294 19 , , , cord-005453-4057qib7 11294 20 p=0.009 p=0.009 NN cord-005453-4057qib7 11294 21 ) ) -RRB- cord-005453-4057qib7 11294 22 and and CC cord-005453-4057qib7 11294 23 disease disease NN cord-005453-4057qib7 11294 24 status status NN cord-005453-4057qib7 11294 25 at at IN cord-005453-4057qib7 11294 26 alloHSCT alloHSCT NNP cord-005453-4057qib7 11294 27 ( ( -LRB- cord-005453-4057qib7 11294 28 CR CR NNP cord-005453-4057qib7 11294 29 -78 -78 NN cord-005453-4057qib7 11294 30 % % NN cord-005453-4057qib7 11294 31 , , , cord-005453-4057qib7 11294 32 PR PR NNP cord-005453-4057qib7 11294 33 -47 -47 CD cord-005453-4057qib7 11294 34 % % NN cord-005453-4057qib7 11294 35 , , , cord-005453-4057qib7 11294 36 NR NR NNP cord-005453-4057qib7 11294 37 -38 -38 NNP cord-005453-4057qib7 11294 38 % % NN cord-005453-4057qib7 11294 39 , , , cord-005453-4057qib7 11294 40 p=0.09 p=0.09 NNP cord-005453-4057qib7 11294 41 ) ) -RRB- cord-005453-4057qib7 11294 42 . . . cord-005453-4057qib7 11295 1 In in IN cord-005453-4057qib7 11295 2 a a DT cord-005453-4057qib7 11295 3 multivariate multivariate JJ cord-005453-4057qib7 11295 4 model model NN cord-005453-4057qib7 11295 5 the the DT cord-005453-4057qib7 11295 6 disease disease NN cord-005453-4057qib7 11295 7 status status NN cord-005453-4057qib7 11295 8 other other JJ cord-005453-4057qib7 11295 9 than than IN cord-005453-4057qib7 11295 10 CR CR NNP cord-005453-4057qib7 11295 11 was be VBD cord-005453-4057qib7 11295 12 the the DT cord-005453-4057qib7 11295 13 only only JJ cord-005453-4057qib7 11295 14 factor factor NN cord-005453-4057qib7 11295 15 associated associate VBN cord-005453-4057qib7 11295 16 with with IN cord-005453-4057qib7 11295 17 increased increase VBN cord-005453-4057qib7 11295 18 risk risk NN cord-005453-4057qib7 11295 19 of of IN cord-005453-4057qib7 11295 20 treatment treatment NN cord-005453-4057qib7 11295 21 failure failure NN cord-005453-4057qib7 11295 22 ( ( -LRB- cord-005453-4057qib7 11295 23 reverse reverse JJ cord-005453-4057qib7 11295 24 PFS PFS NNP cord-005453-4057qib7 11295 25 ) ) -RRB- cord-005453-4057qib7 11296 1 -HR=3.13 -hr=3.13 NN cord-005453-4057qib7 11296 2 , , , cord-005453-4057qib7 11296 3 95%CI 95%ci CD cord-005453-4057qib7 11296 4 1.45 1.45 CD cord-005453-4057qib7 11296 5 - - HYPH cord-005453-4057qib7 11296 6 6.76 6.76 CD cord-005453-4057qib7 11296 7 , , , cord-005453-4057qib7 11296 8 p=0.004 p=0.004 NNP cord-005453-4057qib7 11296 9 . . . cord-005453-4057qib7 11297 1 Neither neither DT cord-005453-4057qib7 11297 2 donor donor NN cord-005453-4057qib7 11297 3 type type NN cord-005453-4057qib7 11297 4 nor nor CC cord-005453-4057qib7 11297 5 conditioning conditioning NN cord-005453-4057qib7 11297 6 affected affect VBN cord-005453-4057qib7 11297 7 long long JJ cord-005453-4057qib7 11297 8 - - HYPH cord-005453-4057qib7 11297 9 term term NN cord-005453-4057qib7 11297 10 outcome outcome NN cord-005453-4057qib7 11297 11 . . . cord-005453-4057qib7 11298 1 Conclusions conclusion NNS cord-005453-4057qib7 11298 2 : : : cord-005453-4057qib7 11299 1 Results result NNS cord-005453-4057qib7 11299 2 of of IN cord-005453-4057qib7 11299 3 alloHSCT allohsct NN cord-005453-4057qib7 11299 4 for for IN cord-005453-4057qib7 11299 5 patients patient NNS cord-005453-4057qib7 11299 6 with with IN cord-005453-4057qib7 11299 7 relapsed relapse VBN cord-005453-4057qib7 11299 8 / / SYM cord-005453-4057qib7 11299 9 refractory refractory JJ cord-005453-4057qib7 11299 10 HL HL NNP cord-005453-4057qib7 11299 11 are be VBP cord-005453-4057qib7 11299 12 determined determine VBN cord-005453-4057qib7 11299 13 by by IN cord-005453-4057qib7 11299 14 disease disease NN cord-005453-4057qib7 11299 15 status status NN cord-005453-4057qib7 11299 16 at at IN cord-005453-4057qib7 11299 17 transplantation transplantation NN cord-005453-4057qib7 11299 18 . . . cord-005453-4057qib7 11300 1 Efforts effort NNS cord-005453-4057qib7 11300 2 should should MD cord-005453-4057qib7 11300 3 be be VB cord-005453-4057qib7 11300 4 done do VBN cord-005453-4057qib7 11300 5 to to TO cord-005453-4057qib7 11300 6 reduce reduce VB cord-005453-4057qib7 11300 7 tumour tumour NN cord-005453-4057qib7 11300 8 burden burden NN cord-005453-4057qib7 11300 9 before before IN cord-005453-4057qib7 11300 10 transplantation transplantation NN cord-005453-4057qib7 11300 11 , , , cord-005453-4057qib7 11300 12 optimally optimally RB cord-005453-4057qib7 11300 13 to to TO cord-005453-4057qib7 11300 14 achieve achieve VB cord-005453-4057qib7 11300 15 CR CR NNP cord-005453-4057qib7 11300 16 . . . cord-005453-4057qib7 11301 1 Disclosure disclosure NN cord-005453-4057qib7 11301 2 : : : cord-005453-4057qib7 11301 3 Nothing nothing NN cord-005453-4057qib7 11301 4 to to TO cord-005453-4057qib7 11301 5 declare declare VB cord-005453-4057qib7 11301 6 Background background NN cord-005453-4057qib7 11301 7 : : : cord-005453-4057qib7 11301 8 Brentuximab Brentuximab NNP cord-005453-4057qib7 11301 9 vedotin vedotin NNP cord-005453-4057qib7 11301 10 ( ( -LRB- cord-005453-4057qib7 11301 11 BV BV NNP cord-005453-4057qib7 11301 12 ) ) -RRB- cord-005453-4057qib7 11301 13 , , , cord-005453-4057qib7 11301 14 nivolumab nivolumab NNP cord-005453-4057qib7 11301 15 and and CC cord-005453-4057qib7 11301 16 pembrolizumab pembrolizumab NNP cord-005453-4057qib7 11301 17 have have VBP cord-005453-4057qib7 11301 18 been be VBN cord-005453-4057qib7 11301 19 assigned assign VBN cord-005453-4057qib7 11301 20 to to IN cord-005453-4057qib7 11301 21 chemorefractory chemorefractory JJ cord-005453-4057qib7 11301 22 Hodgkin Hodgkin NNP cord-005453-4057qib7 11301 23 lymphoma lymphoma NN cord-005453-4057qib7 11301 24 treatment treatment NN cord-005453-4057qib7 11301 25 . . . cord-005453-4057qib7 11302 1 Impact impact NN cord-005453-4057qib7 11302 2 of of IN cord-005453-4057qib7 11302 3 these these DT cord-005453-4057qib7 11302 4 agents agent NNS cord-005453-4057qib7 11302 5 on on IN cord-005453-4057qib7 11302 6 disease disease NN cord-005453-4057qib7 11302 7 - - HYPH cord-005453-4057qib7 11302 8 free free JJ cord-005453-4057qib7 11302 9 - - HYPH cord-005453-4057qib7 11302 10 survival survival NN cord-005453-4057qib7 11302 11 after after IN cord-005453-4057qib7 11302 12 autologous autologous JJ cord-005453-4057qib7 11302 13 stem stem NN cord-005453-4057qib7 11302 14 cell cell NN cord-005453-4057qib7 11302 15 transplantation transplantation NN cord-005453-4057qib7 11302 16 ( ( -LRB- cord-005453-4057qib7 11302 17 ASCT ASCT NNP cord-005453-4057qib7 11302 18 ) ) -RRB- cord-005453-4057qib7 11302 19 remains remain VBZ cord-005453-4057qib7 11302 20 under under IN cord-005453-4057qib7 11302 21 investigation investigation NN cord-005453-4057qib7 11302 22 . . . cord-005453-4057qib7 11303 1 Aim Aim NNP cord-005453-4057qib7 11303 2 of of IN cord-005453-4057qib7 11303 3 the the DT cord-005453-4057qib7 11303 4 study study NN cord-005453-4057qib7 11303 5 is be VBZ cord-005453-4057qib7 11303 6 to to TO cord-005453-4057qib7 11303 7 compare compare VB cord-005453-4057qib7 11303 8 BV BV NNP cord-005453-4057qib7 11303 9 - - : cord-005453-4057qib7 11303 10 and and CC cord-005453-4057qib7 11303 11 nivolumab nivolumab NNP cord-005453-4057qib7 11303 12 - - HYPH cord-005453-4057qib7 11303 13 treated treat VBN cord-005453-4057qib7 11303 14 patients patient NNS cord-005453-4057qib7 11303 15 with with IN cord-005453-4057qib7 11303 16 a a DT cord-005453-4057qib7 11303 17 control control NN cord-005453-4057qib7 11303 18 group group NN cord-005453-4057qib7 11303 19 . . . cord-005453-4057qib7 11304 1 Methods method NNS cord-005453-4057qib7 11304 2 : : : cord-005453-4057qib7 11304 3 Clinical clinical JJ cord-005453-4057qib7 11304 4 characteristics characteristic NNS cord-005453-4057qib7 11304 5 and and CC cord-005453-4057qib7 11304 6 outcomes outcome NNS cord-005453-4057qib7 11304 7 of of IN cord-005453-4057qib7 11304 8 chemo chemo NN cord-005453-4057qib7 11304 9 refractory refractory JJ cord-005453-4057qib7 11304 10 Hodgkin Hodgkin NNP cord-005453-4057qib7 11304 11 lymphoma lymphoma NN cord-005453-4057qib7 11304 12 patients patient NNS cord-005453-4057qib7 11304 13 who who WP cord-005453-4057qib7 11304 14 underwent undergo VBD cord-005453-4057qib7 11304 15 ASCT ASCT NNP cord-005453-4057qib7 11304 16 during during IN cord-005453-4057qib7 11304 17 2011 2011 CD cord-005453-4057qib7 11304 18 - - SYM cord-005453-4057qib7 11304 19 2017 2017 CD cord-005453-4057qib7 11304 20 . . . cord-005453-4057qib7 11305 1 Results result NNS cord-005453-4057qib7 11305 2 : : : cord-005453-4057qib7 11306 1 A a DT cord-005453-4057qib7 11306 2 total total NN cord-005453-4057qib7 11306 3 of of IN cord-005453-4057qib7 11306 4 56 56 CD cord-005453-4057qib7 11306 5 patients patient NNS cord-005453-4057qib7 11306 6 ( ( -LRB- cord-005453-4057qib7 11306 7 33 33 CD cord-005453-4057qib7 11306 8 men man NNS cord-005453-4057qib7 11306 9 ; ; : cord-005453-4057qib7 11306 10 21 21 CD cord-005453-4057qib7 11306 11 women woman NNS cord-005453-4057qib7 11306 12 , , , cord-005453-4057qib7 11306 13 median median JJ cord-005453-4057qib7 11306 14 age age NN cord-005453-4057qib7 11306 15 37 37 CD cord-005453-4057qib7 11306 16 years year NNS cord-005453-4057qib7 11306 17 old old JJ cord-005453-4057qib7 11306 18 , , , cord-005453-4057qib7 11306 19 19 19 CD cord-005453-4057qib7 11306 20 - - SYM cord-005453-4057qib7 11306 21 65 65 CD cord-005453-4057qib7 11306 22 ) ) -RRB- cord-005453-4057qib7 11306 23 were be VBD cord-005453-4057qib7 11306 24 treated treat VBN cord-005453-4057qib7 11306 25 with with IN cord-005453-4057qib7 11306 26 BV BV NNP cord-005453-4057qib7 11306 27 : : : cord-005453-4057qib7 11306 28 24 24 CD cord-005453-4057qib7 11306 29 pre pre JJ cord-005453-4057qib7 11306 30 - - NN cord-005453-4057qib7 11306 31 transplant transplant NN cord-005453-4057qib7 11306 32 , , , cord-005453-4057qib7 11306 33 30 30 CD cord-005453-4057qib7 11306 34 post post NN cord-005453-4057qib7 11306 35 - - JJ cord-005453-4057qib7 11306 36 transplant transplant NN cord-005453-4057qib7 11306 37 and and CC cord-005453-4057qib7 11306 38 7 7 CD cord-005453-4057qib7 11306 39 pre pre JJ cord-005453-4057qib7 11306 40 - - NN cord-005453-4057qib7 11306 41 and and CC cord-005453-4057qib7 11306 42 posttransplant posttransplant NN cord-005453-4057qib7 11306 43 . . . cord-005453-4057qib7 11307 1 Pre pre JJ cord-005453-4057qib7 11307 2 - - JJ cord-005453-4057qib7 11307 3 transplant transplant NN cord-005453-4057qib7 11307 4 BV BV NNP cord-005453-4057qib7 11307 5 patients patient NNS cord-005453-4057qib7 11307 6 had have VBD cord-005453-4057qib7 11307 7 primary primary JJ cord-005453-4057qib7 11307 8 refractory refractory JJ cord-005453-4057qib7 11307 9 disease disease NN cord-005453-4057qib7 11307 10 or or CC cord-005453-4057qib7 11307 11 early early JJ cord-005453-4057qib7 11307 12 relapse relapse NN cord-005453-4057qib7 11307 13 in in IN cord-005453-4057qib7 11307 14 the the DT cord-005453-4057qib7 11307 15 majority majority NN cord-005453-4057qib7 11307 16 ( ( -LRB- cord-005453-4057qib7 11307 17 92 92 CD cord-005453-4057qib7 11307 18 % % NN cord-005453-4057qib7 11307 19 ) ) -RRB- cord-005453-4057qib7 11307 20 . . . cord-005453-4057qib7 11308 1 Post post JJ cord-005453-4057qib7 11308 2 - - JJ cord-005453-4057qib7 11308 3 transplant transplant NN cord-005453-4057qib7 11308 4 treatment treatment NN cord-005453-4057qib7 11308 5 occurred occur VBD cord-005453-4057qib7 11308 6 in in IN cord-005453-4057qib7 11308 7 the the DT cord-005453-4057qib7 11308 8 context context NN cord-005453-4057qib7 11308 9 of of IN cord-005453-4057qib7 11308 10 relapsed relapse VBN cord-005453-4057qib7 11308 11 / / SYM cord-005453-4057qib7 11308 12 refractory refractory JJ cord-005453-4057qib7 11308 13 disease disease NN cord-005453-4057qib7 11308 14 in in IN cord-005453-4057qib7 11308 15 27 27 CD cord-005453-4057qib7 11308 16 patients patient NNS cord-005453-4057qib7 11308 17 ; ; : cord-005453-4057qib7 11308 18 12 12 CD cord-005453-4057qib7 11308 19 ( ( -LRB- cord-005453-4057qib7 11308 20 40 40 CD cord-005453-4057qib7 11308 21 % % NN cord-005453-4057qib7 11308 22 ) ) -RRB- cord-005453-4057qib7 11308 23 had have VBD cord-005453-4057qib7 11308 24 an an DT cord-005453-4057qib7 11308 25 allogeneic allogeneic NN cord-005453-4057qib7 11308 26 stem stem NN cord-005453-4057qib7 11308 27 cell cell NN cord-005453-4057qib7 11308 28 transplant transplant NN cord-005453-4057qib7 11308 29 . . . cord-005453-4057qib7 11309 1 Among among IN cord-005453-4057qib7 11309 2 them -PRON- PRP cord-005453-4057qib7 11309 3 , , , cord-005453-4057qib7 11309 4 6 6 CD cord-005453-4057qib7 11309 5 had have VBD cord-005453-4057qib7 11309 6 additional additional JJ cord-005453-4057qib7 11309 7 chemotherapy chemotherapy NN cord-005453-4057qib7 11309 8 and and CC cord-005453-4057qib7 11309 9 2 2 CD cord-005453-4057qib7 11309 10 nivolumab nivolumab NNS cord-005453-4057qib7 11309 11 , , , cord-005453-4057qib7 11309 12 gaining gain VBG cord-005453-4057qib7 11309 13 a a DT cord-005453-4057qib7 11309 14 complete complete JJ cord-005453-4057qib7 11309 15 metabolic metabolic JJ cord-005453-4057qib7 11309 16 response response NN cord-005453-4057qib7 11309 17 . . . cord-005453-4057qib7 11310 1 In in IN cord-005453-4057qib7 11310 2 the the DT cord-005453-4057qib7 11310 3 15 15 CD cord-005453-4057qib7 11310 4 rest rest NN cord-005453-4057qib7 11310 5 of of IN cord-005453-4057qib7 11310 6 patients patient NNS cord-005453-4057qib7 11310 7 , , , cord-005453-4057qib7 11310 8 change change NN cord-005453-4057qib7 11310 9 of of IN cord-005453-4057qib7 11310 10 treatment treatment NN cord-005453-4057qib7 11310 11 due due IN cord-005453-4057qib7 11310 12 to to IN cord-005453-4057qib7 11310 13 eventual eventual JJ cord-005453-4057qib7 11310 14 BV BV NNP cord-005453-4057qib7 11310 15 failure failure NN cord-005453-4057qib7 11310 16 occurred occur VBD cord-005453-4057qib7 11310 17 . . . cord-005453-4057qib7 11311 1 BV BV NNP cord-005453-4057qib7 11311 2 was be VBD cord-005453-4057qib7 11311 3 administered administer VBN cord-005453-4057qib7 11311 4 as as IN cord-005453-4057qib7 11311 5 a a DT cord-005453-4057qib7 11311 6 maintenance maintenance NN cord-005453-4057qib7 11311 7 treatment treatment NN cord-005453-4057qib7 11311 8 in in IN cord-005453-4057qib7 11311 9 10 10 CD cord-005453-4057qib7 11311 10 patients patient NNS cord-005453-4057qib7 11311 11 . . . cord-005453-4057qib7 11312 1 In in IN cord-005453-4057qib7 11312 2 six six CD cord-005453-4057qib7 11312 3 of of IN cord-005453-4057qib7 11312 4 them -PRON- PRP cord-005453-4057qib7 11312 5 BV BV NNP cord-005453-4057qib7 11312 6 had have VBD cord-005453-4057qib7 11312 7 already already RB cord-005453-4057qib7 11312 8 been be VBN cord-005453-4057qib7 11312 9 administered administer VBN cord-005453-4057qib7 11312 10 pre pre JJ cord-005453-4057qib7 11312 11 - - NN cord-005453-4057qib7 11312 12 transplant transplant NN cord-005453-4057qib7 11312 13 as as RB cord-005453-4057qib7 11312 14 well well RB cord-005453-4057qib7 11312 15 . . . cord-005453-4057qib7 11313 1 Out out IN cord-005453-4057qib7 11313 2 of of IN cord-005453-4057qib7 11313 3 maintenance maintenance NN cord-005453-4057qib7 11313 4 treatment treatment NN cord-005453-4057qib7 11313 5 patients patient NNS cord-005453-4057qib7 11313 6 , , , cord-005453-4057qib7 11313 7 2 2 CD cord-005453-4057qib7 11313 8 relapsed relapse VBD cord-005453-4057qib7 11313 9 and and CC cord-005453-4057qib7 11313 10 subsequently subsequently RB cord-005453-4057qib7 11313 11 received receive VBD cord-005453-4057qib7 11313 12 nivolumab nivolumab NNP cord-005453-4057qib7 11313 13 . . . cord-005453-4057qib7 11314 1 Two two CD cord-005453-4057qib7 11314 2 patients patient NNS cord-005453-4057qib7 11314 3 died die VBD cord-005453-4057qib7 11314 4 due due JJ cord-005453-4057qib7 11314 5 to to IN cord-005453-4057qib7 11314 6 prior prior JJ cord-005453-4057qib7 11314 7 chemotherapy chemotherapy NN cord-005453-4057qib7 11314 8 complications complication NNS cord-005453-4057qib7 11314 9 , , , cord-005453-4057qib7 11314 10 whereas whereas IN cord-005453-4057qib7 11314 11 13 13 CD cord-005453-4057qib7 11314 12 are be VBP cord-005453-4057qib7 11314 13 currently currently RB cord-005453-4057qib7 11314 14 on on IN cord-005453-4057qib7 11314 15 nivolumab nivolumab JJ cord-005453-4057qib7 11314 16 treatment treatment NN cord-005453-4057qib7 11314 17 . . . cord-005453-4057qib7 11315 1 PET pet NN cord-005453-4057qib7 11315 2 - - HYPH cord-005453-4057qib7 11315 3 based base VBN cord-005453-4057qib7 11315 4 response response NN cord-005453-4057qib7 11315 5 was be VBD cord-005453-4057qib7 11315 6 available available JJ cord-005453-4057qib7 11315 7 in in IN cord-005453-4057qib7 11315 8 6 6 CD cord-005453-4057qib7 11315 9 patients patient NNS cord-005453-4057qib7 11315 10 , , , cord-005453-4057qib7 11315 11 4 4 LS cord-005453-4057qib7 11315 12 having have VBG cord-005453-4057qib7 11315 13 a a DT cord-005453-4057qib7 11315 14 complete complete JJ cord-005453-4057qib7 11315 15 metabolic metabolic JJ cord-005453-4057qib7 11315 16 response response NN cord-005453-4057qib7 11315 17 ( ( -LRB- cord-005453-4057qib7 11315 18 CMR CMR NNP cord-005453-4057qib7 11315 19 ) ) -RRB- cord-005453-4057qib7 11315 20 and and CC cord-005453-4057qib7 11315 21 2 2 CD cord-005453-4057qib7 11315 22 a a DT cord-005453-4057qib7 11315 23 partial partial JJ cord-005453-4057qib7 11315 24 metabolic metabolic JJ cord-005453-4057qib7 11315 25 response response NN cord-005453-4057qib7 11315 26 . . . cord-005453-4057qib7 11316 1 Stable stable JJ cord-005453-4057qib7 11316 2 disease disease NN cord-005453-4057qib7 11316 3 was be VBD cord-005453-4057qib7 11316 4 achieved achieve VBN cord-005453-4057qib7 11316 5 by by IN cord-005453-4057qib7 11316 6 CTbased ctbased JJ cord-005453-4057qib7 11316 7 response response NN cord-005453-4057qib7 11316 8 in in IN cord-005453-4057qib7 11316 9 the the DT cord-005453-4057qib7 11316 10 rest rest NN cord-005453-4057qib7 11316 11 patients patient NNS cord-005453-4057qib7 11316 12 . . . cord-005453-4057qib7 11317 1 No no DT cord-005453-4057qib7 11317 2 major major JJ cord-005453-4057qib7 11317 3 toxicities toxicity NNS cord-005453-4057qib7 11317 4 were be VBD cord-005453-4057qib7 11317 5 observed observe VBN cord-005453-4057qib7 11317 6 . . . cord-005453-4057qib7 11318 1 One one CD cord-005453-4057qib7 11318 2 patient patient NN cord-005453-4057qib7 11318 3 presented present VBN cord-005453-4057qib7 11318 4 with with IN cord-005453-4057qib7 11318 5 grade grade NN cord-005453-4057qib7 11318 6 2 2 CD cord-005453-4057qib7 11318 7 asymptomatic asymptomatic JJ cord-005453-4057qib7 11318 8 hypothyroidism hypothyroidism NN cord-005453-4057qib7 11318 9 and and CC cord-005453-4057qib7 11318 10 one one CD cord-005453-4057qib7 11318 11 with with IN cord-005453-4057qib7 11318 12 grade grade NN cord-005453-4057qib7 11318 13 3 3 CD cord-005453-4057qib7 11318 14 anemia anemia NN cord-005453-4057qib7 11318 15 attributed attribute VBN cord-005453-4057qib7 11318 16 to to IN cord-005453-4057qib7 11318 17 non non JJ cord-005453-4057qib7 11318 18 - - JJ cord-005453-4057qib7 11318 19 inflammatory inflammatory JJ cord-005453-4057qib7 11318 20 upper upper JJ cord-005453-4057qib7 11318 21 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 11318 22 blood blood NN cord-005453-4057qib7 11318 23 loss loss NN cord-005453-4057qib7 11318 24 . . . cord-005453-4057qib7 11319 1 In in IN cord-005453-4057qib7 11319 2 total total JJ cord-005453-4057qib7 11319 3 , , , cord-005453-4057qib7 11319 4 20 20 CD cord-005453-4057qib7 11319 5 patients patient NNS cord-005453-4057qib7 11319 6 received receive VBD cord-005453-4057qib7 11319 7 anti anti JJ cord-005453-4057qib7 11319 8 - - JJ cord-005453-4057qib7 11319 9 PD1 pd1 JJ cord-005453-4057qib7 11319 10 treatment treatment NN cord-005453-4057qib7 11319 11 , , , cord-005453-4057qib7 11319 12 all all DT cord-005453-4057qib7 11319 13 post post NN cord-005453-4057qib7 11319 14 BV BV NNP cord-005453-4057qib7 11319 15 failure failure NN cord-005453-4057qib7 11319 16 . . . cord-005453-4057qib7 11320 1 With with IN cord-005453-4057qib7 11320 2 a a DT cord-005453-4057qib7 11320 3 median median JJ cord-005453-4057qib7 11320 4 follow follow NN cord-005453-4057qib7 11320 5 - - HYPH cord-005453-4057qib7 11320 6 up up NN cord-005453-4057qib7 11320 7 of of IN cord-005453-4057qib7 11320 8 34.3 34.3 CD cord-005453-4057qib7 11320 9 ( ( -LRB- cord-005453-4057qib7 11320 10 1.5 1.5 CD cord-005453-4057qib7 11320 11 - - SYM cord-005453-4057qib7 11320 12 202 202 CD cord-005453-4057qib7 11320 13 .2 .2 CD cord-005453-4057qib7 11320 14 ) ) -RRB- cord-005453-4057qib7 11320 15 months month NNS cord-005453-4057qib7 11320 16 , , , cord-005453-4057qib7 11320 17 5-year 5-year CD cord-005453-4057qib7 11320 18 overall overall JJ cord-005453-4057qib7 11320 19 survival survival NN cord-005453-4057qib7 11320 20 ( ( -LRB- cord-005453-4057qib7 11320 21 OS OS NNP cord-005453-4057qib7 11320 22 ) ) -RRB- cord-005453-4057qib7 11320 23 was be VBD cord-005453-4057qib7 11320 24 65.9 65.9 CD cord-005453-4057qib7 11320 25 % % NN cord-005453-4057qib7 11320 26 in in IN cord-005453-4057qib7 11320 27 patients patient NNS cord-005453-4057qib7 11320 28 treated treat VBN cord-005453-4057qib7 11320 29 only only RB cord-005453-4057qib7 11320 30 with with IN cord-005453-4057qib7 11320 31 BV BV NNP cord-005453-4057qib7 11320 32 compared compare VBN cord-005453-4057qib7 11320 33 to to IN cord-005453-4057qib7 11320 34 78.2 78.2 CD cord-005453-4057qib7 11320 35 % % NN cord-005453-4057qib7 11320 36 in in IN cord-005453-4057qib7 11320 37 patients patient NNS cord-005453-4057qib7 11320 38 treated treat VBN cord-005453-4057qib7 11320 39 with with IN cord-005453-4057qib7 11320 40 additional additional JJ cord-005453-4057qib7 11320 41 anti anti JJ cord-005453-4057qib7 11320 42 - - JJ cord-005453-4057qib7 11320 43 PD1 pd1 JJ cord-005453-4057qib7 11320 44 treatment treatment NN cord-005453-4057qib7 11320 45 ( ( -LRB- cord-005453-4057qib7 11320 46 p=0.356 p=0.356 VB cord-005453-4057qib7 11320 47 , , , cord-005453-4057qib7 11320 48 Figure figure NN cord-005453-4057qib7 11320 49 ) ) -RRB- cord-005453-4057qib7 11320 50 . . . cord-005453-4057qib7 11321 1 Median median JJ cord-005453-4057qib7 11321 2 OS os NN cord-005453-4057qib7 11321 3 for for IN cord-005453-4057qib7 11321 4 patients patient NNS cord-005453-4057qib7 11321 5 treated treat VBN cord-005453-4057qib7 11321 6 only only RB cord-005453-4057qib7 11321 7 with with IN cord-005453-4057qib7 11321 8 BV BV NNP cord-005453-4057qib7 11321 9 was be VBD cord-005453-4057qib7 11321 10 113.5 113.5 CD cord-005453-4057qib7 11321 11 months month NNS cord-005453-4057qib7 11321 12 , , , cord-005453-4057qib7 11321 13 whereas whereas IN cord-005453-4057qib7 11321 14 median median JJ cord-005453-4057qib7 11321 15 OS OS NNP cord-005453-4057qib7 11321 16 has have VBZ cord-005453-4057qib7 11321 17 not not RB cord-005453-4057qib7 11321 18 been be VBN cord-005453-4057qib7 11321 19 reached reach VBN cord-005453-4057qib7 11321 20 for for IN cord-005453-4057qib7 11321 21 patients patient NNS cord-005453-4057qib7 11321 22 that that WDT cord-005453-4057qib7 11321 23 received receive VBD cord-005453-4057qib7 11321 24 anti anti JJ cord-005453-4057qib7 11321 25 - - JJ cord-005453-4057qib7 11321 26 PD1 pd1 JJ cord-005453-4057qib7 11321 27 treatment treatment NN cord-005453-4057qib7 11321 28 . . . cord-005453-4057qib7 11322 1 Conclusions conclusion NNS cord-005453-4057qib7 11322 2 : : : cord-005453-4057qib7 11322 3 BV BV NNP cord-005453-4057qib7 11322 4 pre pre VBD cord-005453-4057qib7 11322 5 or or CC cord-005453-4057qib7 11322 6 post post JJ cord-005453-4057qib7 11322 7 - - JJ cord-005453-4057qib7 11322 8 transplant transplant JJ cord-005453-4057qib7 11322 9 and and CC cord-005453-4057qib7 11322 10 anti anti JJ cord-005453-4057qib7 11322 11 - - JJ cord-005453-4057qib7 11322 12 PD1 pd1 JJ cord-005453-4057qib7 11322 13 treatment treatment NN cord-005453-4057qib7 11322 14 post post NN cord-005453-4057qib7 11322 15 - - NN cord-005453-4057qib7 11322 16 transplant transplant NN cord-005453-4057qib7 11322 17 after after IN cord-005453-4057qib7 11322 18 BV BV NNP cord-005453-4057qib7 11322 19 failure failure NN cord-005453-4057qib7 11322 20 have have VBP cord-005453-4057qib7 11322 21 outstanding outstanding JJ cord-005453-4057qib7 11322 22 results result NNS cord-005453-4057qib7 11322 23 in in IN cord-005453-4057qib7 11322 24 chemo chemo NN cord-005453-4057qib7 11322 25 refractory refractory JJ cord-005453-4057qib7 11322 26 lymphoma lymphoma NN cord-005453-4057qib7 11322 27 patients patient NNS cord-005453-4057qib7 11322 28 . . . cord-005453-4057qib7 11323 1 Treatment treatment NN cord-005453-4057qib7 11323 2 sequence sequence NN cord-005453-4057qib7 11323 3 in in IN cord-005453-4057qib7 11323 4 allogeneic allogeneic NN cord-005453-4057qib7 11323 5 transplantation transplantation NN cord-005453-4057qib7 11324 1 eligible eligible JJ cord-005453-4057qib7 11324 2 patients patient NNS cord-005453-4057qib7 11324 3 remains remain VBZ cord-005453-4057qib7 11324 4 to to TO cord-005453-4057qib7 11324 5 be be VB cord-005453-4057qib7 11324 6 further further RB cord-005453-4057qib7 11324 7 studied study VBN cord-005453-4057qib7 11324 8 . . . cord-005453-4057qib7 11325 1 Disclosure disclosure NN cord-005453-4057qib7 11325 2 : : : cord-005453-4057qib7 11325 3 Nothing nothing NN cord-005453-4057qib7 11325 4 to to TO cord-005453-4057qib7 11325 5 declare declare VB cord-005453-4057qib7 11325 6 Background background NN cord-005453-4057qib7 11325 7 : : : cord-005453-4057qib7 11325 8 Allogeneic allogeneic NN cord-005453-4057qib7 11325 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 11325 10 cell cell NN cord-005453-4057qib7 11325 11 transplantation transplantation NN cord-005453-4057qib7 11325 12 ( ( -LRB- cord-005453-4057qib7 11325 13 allo allo NN cord-005453-4057qib7 11325 14 - - HYPH cord-005453-4057qib7 11325 15 HCT HCT NNP cord-005453-4057qib7 11325 16 ) ) -RRB- cord-005453-4057qib7 11325 17 with with IN cord-005453-4057qib7 11325 18 reduced reduce VBN cord-005453-4057qib7 11325 19 - - HYPH cord-005453-4057qib7 11325 20 intensity intensity NN cord-005453-4057qib7 11325 21 conditioning conditioning NN cord-005453-4057qib7 11325 22 ( ( -LRB- cord-005453-4057qib7 11325 23 RIC RIC NNP cord-005453-4057qib7 11325 24 ) ) -RRB- cord-005453-4057qib7 11325 25 has have VBZ cord-005453-4057qib7 11325 26 been be VBN cord-005453-4057qib7 11325 27 used use VBN cord-005453-4057qib7 11325 28 in in IN cord-005453-4057qib7 11325 29 heavily heavily RB cord-005453-4057qib7 11325 30 pretreated pretreate VBN cord-005453-4057qib7 11325 31 lymphoma lymphoma NN cord-005453-4057qib7 11325 32 patients patient NNS cord-005453-4057qib7 11325 33 with with IN cord-005453-4057qib7 11325 34 the the DT cord-005453-4057qib7 11325 35 promise promise NN cord-005453-4057qib7 11325 36 of of IN cord-005453-4057qib7 11325 37 decreased decrease VBN cord-005453-4057qib7 11325 38 treatment treatment NN cord-005453-4057qib7 11325 39 - - HYPH cord-005453-4057qib7 11325 40 related relate VBN cord-005453-4057qib7 11325 41 mortality mortality NN cord-005453-4057qib7 11325 42 . . . cord-005453-4057qib7 11326 1 Despite despite IN cord-005453-4057qib7 11326 2 improvements improvement NNS cord-005453-4057qib7 11326 3 in in IN cord-005453-4057qib7 11326 4 outcomes outcome NNS cord-005453-4057qib7 11326 5 of of IN cord-005453-4057qib7 11326 6 patients patient NNS cord-005453-4057qib7 11326 7 with with IN cord-005453-4057qib7 11326 8 lymphoid lymphoid JJ cord-005453-4057qib7 11326 9 neoplasms neoplasm NNS cord-005453-4057qib7 11326 10 , , , cord-005453-4057qib7 11326 11 several several JJ cord-005453-4057qib7 11326 12 new new JJ cord-005453-4057qib7 11326 13 agents agent NNS cord-005453-4057qib7 11326 14 emerge emerge VBP cord-005453-4057qib7 11326 15 as as IN cord-005453-4057qib7 11326 16 potential potential JJ cord-005453-4057qib7 11326 17 therapies therapy NNS cord-005453-4057qib7 11326 18 . . . cord-005453-4057qib7 11327 1 Therefore therefore RB cord-005453-4057qib7 11327 2 , , , cord-005453-4057qib7 11327 3 we -PRON- PRP cord-005453-4057qib7 11327 4 aimed aim VBD cord-005453-4057qib7 11327 5 to to TO cord-005453-4057qib7 11327 6 describe describe VB cord-005453-4057qib7 11327 7 our -PRON- PRP$ cord-005453-4057qib7 11327 8 long long JJ cord-005453-4057qib7 11327 9 - - HYPH cord-005453-4057qib7 11327 10 term term NN cord-005453-4057qib7 11327 11 experience experience NN cord-005453-4057qib7 11327 12 in in IN cord-005453-4057qib7 11327 13 patients patient NNS cord-005453-4057qib7 11327 14 with with IN cord-005453-4057qib7 11327 15 Hodgkin Hodgkin NNP cord-005453-4057qib7 11327 16 ( ( -LRB- cord-005453-4057qib7 11327 17 HL HL NNP cord-005453-4057qib7 11327 18 ) ) -RRB- cord-005453-4057qib7 11327 19 , , , cord-005453-4057qib7 11327 20 non non JJ cord-005453-4057qib7 11327 21 - - JJ cord-005453-4057qib7 11327 22 Hodgkin Hodgkin NNP cord-005453-4057qib7 11327 23 lymphomas lymphoma NNS cord-005453-4057qib7 11327 24 ( ( -LRB- cord-005453-4057qib7 11327 25 NHL NHL NNP cord-005453-4057qib7 11327 26 ) ) -RRB- cord-005453-4057qib7 11327 27 and and CC cord-005453-4057qib7 11327 28 chronic chronic JJ cord-005453-4057qib7 11327 29 lymphocytic lymphocytic JJ cord-005453-4057qib7 11327 30 leukemia leukemia NN cord-005453-4057qib7 11327 31 ( ( -LRB- cord-005453-4057qib7 11327 32 CLL CLL NNP cord-005453-4057qib7 11327 33 ) ) -RRB- cord-005453-4057qib7 11327 34 post post NN cord-005453-4057qib7 11327 35 allo allo NN cord-005453-4057qib7 11327 36 - - HYPH cord-005453-4057qib7 11327 37 HCT HCT NNP cord-005453-4057qib7 11327 38 . . . cord-005453-4057qib7 11328 1 Methods method NNS cord-005453-4057qib7 11328 2 : : : cord-005453-4057qib7 11328 3 In in IN cord-005453-4057qib7 11328 4 this this DT cord-005453-4057qib7 11328 5 retrospective retrospective JJ cord-005453-4057qib7 11328 6 study study NN cord-005453-4057qib7 11328 7 , , , cord-005453-4057qib7 11328 8 we -PRON- PRP cord-005453-4057qib7 11328 9 enrolled enrol VBD cord-005453-4057qib7 11328 10 consecutive consecutive JJ cord-005453-4057qib7 11328 11 patients patient NNS cord-005453-4057qib7 11328 12 who who WP cord-005453-4057qib7 11328 13 underwent undergo VBD cord-005453-4057qib7 11328 14 allo allo NN cord-005453-4057qib7 11328 15 - - HYPH cord-005453-4057qib7 11328 16 HCT hct NN cord-005453-4057qib7 11328 17 for for IN cord-005453-4057qib7 11328 18 lymphoid lymphoid JJ cord-005453-4057qib7 11328 19 neoplasms neoplasm NNS cord-005453-4057qib7 11328 20 in in IN cord-005453-4057qib7 11328 21 our -PRON- PRP$ cord-005453-4057qib7 11328 22 institution institution NN cord-005453-4057qib7 11328 23 ( ( -LRB- cord-005453-4057qib7 11328 24 2001 2001 CD cord-005453-4057qib7 11328 25 ) ) -RRB- cord-005453-4057qib7 11328 26 ( ( -LRB- cord-005453-4057qib7 11328 27 2002 2002 CD cord-005453-4057qib7 11328 28 ) ) -RRB- cord-005453-4057qib7 11329 1 ( ( -LRB- cord-005453-4057qib7 11329 2 2003 2003 CD cord-005453-4057qib7 11329 3 ) ) -RRB- cord-005453-4057qib7 11330 1 ( ( -LRB- cord-005453-4057qib7 11330 2 2004 2004 CD cord-005453-4057qib7 11330 3 ) ) -RRB- cord-005453-4057qib7 11331 1 ( ( -LRB- cord-005453-4057qib7 11331 2 2005 2005 CD cord-005453-4057qib7 11331 3 ) ) -RRB- cord-005453-4057qib7 11332 1 ( ( -LRB- cord-005453-4057qib7 11332 2 2006 2006 CD cord-005453-4057qib7 11332 3 ) ) -RRB- cord-005453-4057qib7 11333 1 ( ( -LRB- cord-005453-4057qib7 11333 2 2007 2007 CD cord-005453-4057qib7 11333 3 ) ) -RRB- cord-005453-4057qib7 11334 1 ( ( -LRB- cord-005453-4057qib7 11334 2 2008 2008 CD cord-005453-4057qib7 11334 3 ) ) -RRB- cord-005453-4057qib7 11335 1 ( ( -LRB- cord-005453-4057qib7 11335 2 2009 2009 CD cord-005453-4057qib7 11335 3 ) ) -RRB- cord-005453-4057qib7 11336 1 ( ( -LRB- cord-005453-4057qib7 11336 2 2010 2010 CD cord-005453-4057qib7 11336 3 ) ) -RRB- cord-005453-4057qib7 11337 1 ( ( -LRB- cord-005453-4057qib7 11337 2 2011 2011 CD cord-005453-4057qib7 11337 3 ) ) -RRB- cord-005453-4057qib7 11338 1 ( ( -LRB- cord-005453-4057qib7 11338 2 2012 2012 CD cord-005453-4057qib7 11338 3 ) ) -RRB- cord-005453-4057qib7 11339 1 ( ( -LRB- cord-005453-4057qib7 11339 2 2013 2013 CD cord-005453-4057qib7 11339 3 ) ) -RRB- cord-005453-4057qib7 11340 1 ( ( -LRB- cord-005453-4057qib7 11340 2 2014 2014 CD cord-005453-4057qib7 11340 3 ) ) -RRB- cord-005453-4057qib7 11340 4 ( ( -LRB- cord-005453-4057qib7 11340 5 2015 2015 CD cord-005453-4057qib7 11340 6 ) ) -RRB- cord-005453-4057qib7 11340 7 ( ( -LRB- cord-005453-4057qib7 11340 8 2016 2016 CD cord-005453-4057qib7 11340 9 ) ) -RRB- cord-005453-4057qib7 11340 10 ( ( -LRB- cord-005453-4057qib7 11340 11 2017 2017 CD cord-005453-4057qib7 11340 12 ) ) -RRB- cord-005453-4057qib7 11340 13 ( ( -LRB- cord-005453-4057qib7 11340 14 2018 2018 CD cord-005453-4057qib7 11340 15 ) ) -RRB- cord-005453-4057qib7 11340 16 . . . cord-005453-4057qib7 11341 1 Results result NNS cord-005453-4057qib7 11341 2 : : : cord-005453-4057qib7 11342 1 In in IN cord-005453-4057qib7 11342 2 total total NN cord-005453-4057qib7 11342 3 , , , cord-005453-4057qib7 11342 4 50 50 CD cord-005453-4057qib7 11342 5 patients patient NNS cord-005453-4057qib7 11342 6 ( ( -LRB- cord-005453-4057qib7 11342 7 male male JJ cord-005453-4057qib7 11342 8 : : : cord-005453-4057qib7 11342 9 female=35:25 female=35:25 CD cord-005453-4057qib7 11342 10 ) ) -RRB- cord-005453-4057qib7 11342 11 aged age VBN cord-005453-4057qib7 11342 12 36 36 CD cord-005453-4057qib7 11342 13 ( ( -LRB- cord-005453-4057qib7 11342 14 15 15 CD cord-005453-4057qib7 11342 15 - - SYM cord-005453-4057qib7 11342 16 64 64 CD cord-005453-4057qib7 11342 17 ) ) -RRB- cord-005453-4057qib7 11342 18 years year NNS cord-005453-4057qib7 11342 19 , , , cord-005453-4057qib7 11342 20 underwent undergo VBD cord-005453-4057qib7 11342 21 allo allo NN cord-005453-4057qib7 11342 22 - - HYPH cord-005453-4057qib7 11342 23 HCT hct NN cord-005453-4057qib7 11342 24 for for IN cord-005453-4057qib7 11342 25 HL HL NNP cord-005453-4057qib7 11342 26 ( ( -LRB- cord-005453-4057qib7 11342 27 n=24 n=24 NNP cord-005453-4057qib7 11342 28 ) ) -RRB- cord-005453-4057qib7 11342 29 , , , cord-005453-4057qib7 11342 30 NHL NHL NNP cord-005453-4057qib7 11342 31 ( ( -LRB- cord-005453-4057qib7 11342 32 n=21 n=21 NNP cord-005453-4057qib7 11342 33 ) ) -RRB- cord-005453-4057qib7 11342 34 and and CC cord-005453-4057qib7 11342 35 CLL CLL NNP cord-005453-4057qib7 11342 36 ( ( -LRB- cord-005453-4057qib7 11342 37 n=5 n=5 NNP cord-005453-4057qib7 11342 38 ) ) -RRB- cord-005453-4057qib7 11342 39 . . . cord-005453-4057qib7 11343 1 The the DT cord-005453-4057qib7 11343 2 majority majority NN cord-005453-4057qib7 11343 3 of of IN cord-005453-4057qib7 11343 4 patients patient NNS cord-005453-4057qib7 11343 5 were be VBD cord-005453-4057qib7 11343 6 diagnosed diagnose VBN cord-005453-4057qib7 11343 7 at at IN cord-005453-4057qib7 11343 8 stage stage NN cord-005453-4057qib7 11343 9 IV IV NNP cord-005453-4057qib7 11343 10 ( ( -LRB- cord-005453-4057qib7 11343 11 48 48 CD cord-005453-4057qib7 11343 12 % % NN cord-005453-4057qib7 11343 13 ) ) -RRB- cord-005453-4057qib7 11343 14 ; ; : cord-005453-4057qib7 11343 15 34 34 CD cord-005453-4057qib7 11343 16 % % NN cord-005453-4057qib7 11343 17 had have VBD cord-005453-4057qib7 11343 18 bone bone NN cord-005453-4057qib7 11343 19 marrow marrow NN cord-005453-4057qib7 11343 20 involvement involvement NN cord-005453-4057qib7 11343 21 and and CC cord-005453-4057qib7 11343 22 66 66 CD cord-005453-4057qib7 11343 23 % % NN cord-005453-4057qib7 11343 24 had have VBD cord-005453-4057qib7 11343 25 undergone undergo VBN cord-005453-4057qib7 11343 26 autologous autologous JJ cord-005453-4057qib7 11343 27 HCT hct NN cord-005453-4057qib7 11343 28 . . . cord-005453-4057qib7 11344 1 Most Most JJS cord-005453-4057qib7 11344 2 patients patient NNS cord-005453-4057qib7 11344 3 were be VBD cord-005453-4057qib7 11344 4 heavily heavily RB cord-005453-4057qib7 11344 5 pretreated pretreate VBN cord-005453-4057qib7 11344 6 ( ( -LRB- cord-005453-4057qib7 11344 7 median median NN cord-005453-4057qib7 11344 8 lines=4 lines=4 NNS cord-005453-4057qib7 11344 9 , , , cord-005453-4057qib7 11344 10 range range VBP cord-005453-4057qib7 11344 11 1 1 CD cord-005453-4057qib7 11344 12 - - SYM cord-005453-4057qib7 11344 13 11 11 CD cord-005453-4057qib7 11344 14 ) ) -RRB- cord-005453-4057qib7 11344 15 , , , cord-005453-4057qib7 11344 16 21 21 CD cord-005453-4057qib7 11344 17 of of IN cord-005453-4057qib7 11344 18 them -PRON- PRP cord-005453-4057qib7 11344 19 had have VBD cord-005453-4057qib7 11344 20 received receive VBN cord-005453-4057qib7 11344 21 more more JJR cord-005453-4057qib7 11344 22 than than IN cord-005453-4057qib7 11344 23 4 4 CD cord-005453-4057qib7 11344 24 treatment treatment NN cord-005453-4057qib7 11344 25 lines line NNS cord-005453-4057qib7 11344 26 and and CC cord-005453-4057qib7 11344 27 at at IN cord-005453-4057qib7 11344 28 the the DT cord-005453-4057qib7 11344 29 time time NN cord-005453-4057qib7 11344 30 of of IN cord-005453-4057qib7 11344 31 transplantation transplantation NN cord-005453-4057qib7 11344 32 only only RB cord-005453-4057qib7 11344 33 14 14 CD cord-005453-4057qib7 11344 34 had have VBD cord-005453-4057qib7 11344 35 complete complete JJ cord-005453-4057qib7 11344 36 response response NN cord-005453-4057qib7 11344 37 , , , cord-005453-4057qib7 11344 38 while while IN cord-005453-4057qib7 11344 39 9 9 CD cord-005453-4057qib7 11344 40 had have VBD cord-005453-4057qib7 11344 41 partial partial JJ cord-005453-4057qib7 11344 42 response response NN cord-005453-4057qib7 11344 43 and and CC cord-005453-4057qib7 11344 44 27 27 CD cord-005453-4057qib7 11344 45 were be VBD cord-005453-4057qib7 11344 46 refractory refractory JJ cord-005453-4057qib7 11344 47 . . . cord-005453-4057qib7 11345 1 According accord VBG cord-005453-4057qib7 11345 2 to to IN cord-005453-4057qib7 11345 3 Disease Disease NNP cord-005453-4057qib7 11345 4 - - HYPH cord-005453-4057qib7 11345 5 Risk Risk NNP cord-005453-4057qib7 11345 6 Index Index NNP cord-005453-4057qib7 11345 7 ( ( -LRB- cord-005453-4057qib7 11345 8 DRI DRI NNP cord-005453-4057qib7 11345 9 ) ) -RRB- cord-005453-4057qib7 11345 10 , , , cord-005453-4057qib7 11345 11 patients patient NNS cord-005453-4057qib7 11345 12 were be VBD cord-005453-4057qib7 11345 13 stratified stratify VBN cord-005453-4057qib7 11345 14 at at IN cord-005453-4057qib7 11345 15 low low JJ cord-005453-4057qib7 11345 16 ( ( -LRB- cord-005453-4057qib7 11345 17 n=11 n=11 NNP cord-005453-4057qib7 11345 18 , , , cord-005453-4057qib7 11345 19 23.4 23.4 CD cord-005453-4057qib7 11345 20 % % NN cord-005453-4057qib7 11345 21 ) ) -RRB- cord-005453-4057qib7 11345 22 , , , cord-005453-4057qib7 11345 23 intermediate intermediate JJ cord-005453-4057qib7 11345 24 ( ( -LRB- cord-005453-4057qib7 11345 25 n=12 n=12 NNP cord-005453-4057qib7 11345 26 , , , cord-005453-4057qib7 11345 27 25.5 25.5 CD cord-005453-4057qib7 11345 28 % % NN cord-005453-4057qib7 11345 29 ) ) -RRB- cord-005453-4057qib7 11345 30 , , , cord-005453-4057qib7 11345 31 high high JJ cord-005453-4057qib7 11345 32 ( ( -LRB- cord-005453-4057qib7 11345 33 n=20 n=20 NN cord-005453-4057qib7 11345 34 , , , cord-005453-4057qib7 11345 35 42.6 42.6 CD cord-005453-4057qib7 11345 36 % % NN cord-005453-4057qib7 11345 37 ) ) -RRB- cord-005453-4057qib7 11345 38 or or CC cord-005453-4057qib7 11345 39 very very RB cord-005453-4057qib7 11345 40 high high JJ cord-005453-4057qib7 11345 41 ( ( -LRB- cord-005453-4057qib7 11345 42 n=4 n=4 JJ cord-005453-4057qib7 11345 43 , , , cord-005453-4057qib7 11345 44 8.5 8.5 CD cord-005453-4057qib7 11345 45 % % NN cord-005453-4057qib7 11345 46 ) ) -RRB- cord-005453-4057qib7 11345 47 category category NN cord-005453-4057qib7 11345 48 . . . cord-005453-4057qib7 11346 1 Among among IN cord-005453-4057qib7 11346 2 patients patient NNS cord-005453-4057qib7 11346 3 with with IN cord-005453-4057qib7 11346 4 Hodgkin Hodgkin NNP cord-005453-4057qib7 11346 5 lymphoma lymphoma NN cord-005453-4057qib7 11346 6 , , , cord-005453-4057qib7 11346 7 Brentuximab Brentuximab NNP cord-005453-4057qib7 11346 8 vedotin vedotin NNP cord-005453-4057qib7 11346 9 was be VBD cord-005453-4057qib7 11346 10 administrated administrate VBN cord-005453-4057qib7 11346 11 in in IN cord-005453-4057qib7 11346 12 7 7 CD cord-005453-4057qib7 11346 13 and and CC cord-005453-4057qib7 11346 14 4 4 CD cord-005453-4057qib7 11346 15 of of IN cord-005453-4057qib7 11346 16 them -PRON- PRP cord-005453-4057qib7 11346 17 were be VBD cord-005453-4057qib7 11346 18 effectively effectively RB cord-005453-4057qib7 11346 19 bridged bridge VBN cord-005453-4057qib7 11346 20 to to IN cord-005453-4057qib7 11346 21 allo allo NN cord-005453-4057qib7 11346 22 - - HYPH cord-005453-4057qib7 11346 23 HCT hct NN cord-005453-4057qib7 11346 24 . . . cord-005453-4057qib7 11347 1 All all DT cord-005453-4057qib7 11347 2 patients patient NNS cord-005453-4057qib7 11347 3 received receive VBD cord-005453-4057qib7 11347 4 RIC RIC NNP cord-005453-4057qib7 11347 5 , , , cord-005453-4057qib7 11347 6 mainly mainly RB cord-005453-4057qib7 11347 7 Fludarabine Fludarabine NNP cord-005453-4057qib7 11347 8 ( ( -LRB- cord-005453-4057qib7 11347 9 150mg/ 150mg/ CD cord-005453-4057qib7 11347 10 m m CD cord-005453-4057qib7 11347 11 2 2 CD cord-005453-4057qib7 11347 12 ) ) -RRB- cord-005453-4057qib7 11347 13 -Cyclophosphamide -Cyclophosphamide . cord-005453-4057qib7 11348 1 ( ( -LRB- cord-005453-4057qib7 11348 2 2g/ 2g/ CD cord-005453-4057qib7 11348 3 m m CD cord-005453-4057qib7 11348 4 2 2 CD cord-005453-4057qib7 11348 5 ) ) -RRB- cord-005453-4057qib7 11348 6 in in IN cord-005453-4057qib7 11348 7 CLL CLL NNP cord-005453-4057qib7 11348 8 and and CC cord-005453-4057qib7 11348 9 NHL NHL NNP cord-005453-4057qib7 11348 10 and and CC cord-005453-4057qib7 11348 11 Thiotepa Thiotepa NNP cord-005453-4057qib7 11348 12 ( ( -LRB- cord-005453-4057qib7 11348 13 10mg 10mg NNP cord-005453-4057qib7 11348 14 / / SYM cord-005453-4057qib7 11348 15 kg)-Fludarabine kg)-Fludarabine NNP cord-005453-4057qib7 11348 16 ( ( -LRB- cord-005453-4057qib7 11348 17 120 120 CD cord-005453-4057qib7 11348 18 mg mg NNP cord-005453-4057qib7 11348 19 / / SYM cord-005453-4057qib7 11348 20 m m NN cord-005453-4057qib7 11348 21 2 2 CD cord-005453-4057qib7 11348 22 ) ) -RRB- cord-005453-4057qib7 11349 1 -Cyclophosphamide -cyclophosphamide RB cord-005453-4057qib7 11350 1 ( ( -LRB- cord-005453-4057qib7 11350 2 60mg 60mg NNP cord-005453-4057qib7 11350 3 / / SYM cord-005453-4057qib7 11350 4 kg kg NNP cord-005453-4057qib7 11350 5 ) ) -RRB- cord-005453-4057qib7 11350 6 in in IN cord-005453-4057qib7 11350 7 HL HL NNP cord-005453-4057qib7 11350 8 from from IN cord-005453-4057qib7 11350 9 matched match VBN cord-005453-4057qib7 11350 10 sibling sibling NN cord-005453-4057qib7 11350 11 ( ( -LRB- cord-005453-4057qib7 11350 12 n=27 n=27 NNP cord-005453-4057qib7 11350 13 ) ) -RRB- cord-005453-4057qib7 11350 14 , , , cord-005453-4057qib7 11350 15 matched match VBN cord-005453-4057qib7 11350 16 ( ( -LRB- cord-005453-4057qib7 11350 17 n=15 n=15 NNP cord-005453-4057qib7 11350 18 ) ) -RRB- cord-005453-4057qib7 11350 19 or or CC cord-005453-4057qib7 11350 20 mismatched mismatch VBN cord-005453-4057qib7 11350 21 unrelated unrelated JJ cord-005453-4057qib7 11350 22 ( ( -LRB- cord-005453-4057qib7 11350 23 n=8 n=8 NN cord-005453-4057qib7 11350 24 ) ) -RRB- cord-005453-4057qib7 11350 25 donors donor NNS cord-005453-4057qib7 11350 26 . . . cord-005453-4057qib7 11351 1 Graft graft NN cord-005453-4057qib7 11351 2 - - HYPH cord-005453-4057qib7 11351 3 versus versus IN cord-005453-4057qib7 11351 4 - - HYPH cord-005453-4057qib7 11351 5 host host NN cord-005453-4057qib7 11351 6 disease disease NN cord-005453-4057qib7 11351 7 ( ( -LRB- cord-005453-4057qib7 11351 8 GVHD GVHD NNP cord-005453-4057qib7 11351 9 ) ) -RRB- cord-005453-4057qib7 11351 10 prophylaxis prophylaxis NN cord-005453-4057qib7 11351 11 consisted consist VBD cord-005453-4057qib7 11351 12 of of IN cord-005453-4057qib7 11351 13 cyclosporine cyclosporine NN cord-005453-4057qib7 11351 14 or or CC cord-005453-4057qib7 11351 15 tacrolimus tacrolimus NN cord-005453-4057qib7 11351 16 and and CC cord-005453-4057qib7 11351 17 mycophenolate mycophenolate NNP cord-005453-4057qib7 11351 18 mofetil mofetil NNP cord-005453-4057qib7 11351 19 or or CC cord-005453-4057qib7 11351 20 short short JJ cord-005453-4057qib7 11351 21 - - HYPH cord-005453-4057qib7 11351 22 term term NN cord-005453-4057qib7 11351 23 methotrexate methotrexate NNP cord-005453-4057qib7 11351 24 and and CC cord-005453-4057qib7 11351 25 additional additional JJ cord-005453-4057qib7 11351 26 low low JJ cord-005453-4057qib7 11351 27 - - HYPH cord-005453-4057qib7 11351 28 dose dose NN cord-005453-4057qib7 11351 29 antithymocyte antithymocyte NNP cord-005453-4057qib7 11351 30 globulin globulin NN cord-005453-4057qib7 11351 31 ( ( -LRB- cord-005453-4057qib7 11351 32 5mg 5mg NNP cord-005453-4057qib7 11351 33 / / SYM cord-005453-4057qib7 11351 34 kg kg NNP cord-005453-4057qib7 11351 35 ) ) -RRB- cord-005453-4057qib7 11351 36 in in IN cord-005453-4057qib7 11351 37 unrelated unrelated JJ cord-005453-4057qib7 11351 38 donors donor NNS cord-005453-4057qib7 11351 39 . . . cord-005453-4057qib7 11352 1 Peripheral peripheral JJ cord-005453-4057qib7 11352 2 blood blood NN cord-005453-4057qib7 11352 3 was be VBD cord-005453-4057qib7 11352 4 the the DT cord-005453-4057qib7 11352 5 main main JJ cord-005453-4057qib7 11352 6 cell cell NN cord-005453-4057qib7 11352 7 source source NN cord-005453-4057qib7 11352 8 ( ( -LRB- cord-005453-4057qib7 11352 9 48/50 48/50 CD cord-005453-4057qib7 11352 10 ) ) -RRB- cord-005453-4057qib7 11352 11 and and CC cord-005453-4057qib7 11352 12 median median JJ cord-005453-4057qib7 11352 13 number number NN cord-005453-4057qib7 11352 14 of of IN cord-005453-4057qib7 11352 15 CD34 CD34 NNP cord-005453-4057qib7 11352 16 + + CC cord-005453-4057qib7 11352 17 cells cell NNS cord-005453-4057qib7 11352 18 infused infuse VBN cord-005453-4057qib7 11352 19 was be VBD cord-005453-4057qib7 11352 20 6.37x10 6.37x10 CD cord-005453-4057qib7 11352 21 6 6 CD cord-005453-4057qib7 11353 1 /kg /kg NFP cord-005453-4057qib7 11353 2 ( ( -LRB- cord-005453-4057qib7 11353 3 1.33 1.33 CD cord-005453-4057qib7 11353 4 - - SYM cord-005453-4057qib7 11353 5 14.5 14.5 CD cord-005453-4057qib7 11353 6 ) ) -RRB- cord-005453-4057qib7 11353 7 . . . cord-005453-4057qib7 11354 1 Two two CD cord-005453-4057qib7 11354 2 patients patient NNS cord-005453-4057qib7 11354 3 succumbed succumb VBD cord-005453-4057qib7 11354 4 to to IN cord-005453-4057qib7 11354 5 advanced advanced JJ cord-005453-4057qib7 11354 6 underlying underlying JJ cord-005453-4057qib7 11354 7 disease disease NN cord-005453-4057qib7 11354 8 before before IN cord-005453-4057qib7 11354 9 engraftment engraftment NN cord-005453-4057qib7 11354 10 ; ; : cord-005453-4057qib7 11354 11 while while IN cord-005453-4057qib7 11354 12 the the DT cord-005453-4057qib7 11354 13 other other JJ cord-005453-4057qib7 11354 14 engrafted engraft VBD cord-005453-4057qib7 11354 15 successfully successfully RB cord-005453-4057qib7 11354 16 . . . cord-005453-4057qib7 11355 1 Median median JJ cord-005453-4057qib7 11355 2 time time NN cord-005453-4057qib7 11355 3 until until IN cord-005453-4057qib7 11355 4 neutrophil neutrophil NN cord-005453-4057qib7 11355 5 and and CC cord-005453-4057qib7 11355 6 platelet platelet NN cord-005453-4057qib7 11355 7 engraftment engraftment NN cord-005453-4057qib7 11355 8 was be VBD cord-005453-4057qib7 11355 9 10 10 CD cord-005453-4057qib7 11355 10 and and CC cord-005453-4057qib7 11355 11 12 12 CD cord-005453-4057qib7 11355 12 days day NNS cord-005453-4057qib7 11355 13 respectively respectively RB cord-005453-4057qib7 11355 14 . . . cord-005453-4057qib7 11356 1 Eighteen eighteen CD cord-005453-4057qib7 11356 2 patients patient NNS cord-005453-4057qib7 11356 3 ( ( -LRB- cord-005453-4057qib7 11356 4 36.7 36.7 CD cord-005453-4057qib7 11356 5 % % NN cord-005453-4057qib7 11356 6 ) ) -RRB- cord-005453-4057qib7 11356 7 developed develop VBN cord-005453-4057qib7 11356 8 acute acute JJ cord-005453-4057qib7 11356 9 GVHD GVHD NNP cord-005453-4057qib7 11356 10 ( ( -LRB- cord-005453-4057qib7 11356 11 grade grade NN cord-005453-4057qib7 11356 12 III III NNP cord-005453-4057qib7 11356 13 - - HYPH cord-005453-4057qib7 11356 14 IV IV NNP cord-005453-4057qib7 11356 15 , , , cord-005453-4057qib7 11356 16 n=5 n=5 JJ cord-005453-4057qib7 11356 17 ) ) -RRB- cord-005453-4057qib7 11356 18 , , , cord-005453-4057qib7 11356 19 steroid steroid NN cord-005453-4057qib7 11356 20 sensitive sensitive JJ cord-005453-4057qib7 11356 21 in in IN cord-005453-4057qib7 11356 22 10 10 CD cord-005453-4057qib7 11356 23 ( ( -LRB- cord-005453-4057qib7 11356 24 62.5 62.5 CD cord-005453-4057qib7 11356 25 % % NN cord-005453-4057qib7 11356 26 ) ) -RRB- cord-005453-4057qib7 11356 27 and and CC cord-005453-4057qib7 11356 28 11 11 CD cord-005453-4057qib7 11356 29 relapsed relapse VBD cord-005453-4057qib7 11356 30 . . . cord-005453-4057qib7 11357 1 One one CD cord-005453-4057qib7 11357 2 - - HYPH cord-005453-4057qib7 11357 3 year year NN cord-005453-4057qib7 11357 4 cumulative cumulative JJ cord-005453-4057qib7 11357 5 incidence incidence NN cord-005453-4057qib7 11357 6 ( ( -LRB- cord-005453-4057qib7 11357 7 CI CI NNP cord-005453-4057qib7 11357 8 ) ) -RRB- cord-005453-4057qib7 11357 9 of of IN cord-005453-4057qib7 11357 10 extensive extensive JJ cord-005453-4057qib7 11357 11 chronic chronic JJ cord-005453-4057qib7 11357 12 GVHD GVHD NNP cord-005453-4057qib7 11357 13 was be VBD cord-005453-4057qib7 11357 14 78.2 78.2 CD cord-005453-4057qib7 11357 15 % % NN cord-005453-4057qib7 11357 16 , , , cord-005453-4057qib7 11357 17 and and CC cord-005453-4057qib7 11357 18 13 13 CD cord-005453-4057qib7 11357 19 patients patient NNS cord-005453-4057qib7 11357 20 required require VBD cord-005453-4057qib7 11357 21 more more JJR cord-005453-4057qib7 11357 22 than than IN cord-005453-4057qib7 11357 23 one one CD cord-005453-4057qib7 11357 24 additional additional JJ cord-005453-4057qib7 11357 25 line line NN cord-005453-4057qib7 11357 26 of of IN cord-005453-4057qib7 11357 27 immunosuppression immunosuppression NN cord-005453-4057qib7 11357 28 ( ( -LRB- cord-005453-4057qib7 11357 29 range range NNP cord-005453-4057qib7 11357 30 1 1 CD cord-005453-4057qib7 11357 31 - - SYM cord-005453-4057qib7 11357 32 5 5 CD cord-005453-4057qib7 11357 33 ) ) -RRB- cord-005453-4057qib7 11357 34 . . . cord-005453-4057qib7 11358 1 Ten ten CD cord-005453-4057qib7 11358 2 patients patient NNS cord-005453-4057qib7 11358 3 presented present VBD cord-005453-4057qib7 11358 4 CMV CMV NNP cord-005453-4057qib7 11358 5 reactivation reactivation NN cord-005453-4057qib7 11358 6 successfully successfully RB cord-005453-4057qib7 11358 7 treated treat VBN cord-005453-4057qib7 11358 8 with with IN cord-005453-4057qib7 11358 9 antiviral antiviral JJ cord-005453-4057qib7 11358 10 medication medication NN cord-005453-4057qib7 11358 11 and and CC cord-005453-4057qib7 11358 12 1 1 CD cord-005453-4057qib7 11358 13 patient patient NN cord-005453-4057qib7 11358 14 died die VBD cord-005453-4057qib7 11358 15 from from IN cord-005453-4057qib7 11358 16 HSV7 HSV7 NNP cord-005453-4057qib7 11358 17 encephalitis encephalitis NNP cord-005453-4057qib7 11358 18 . . . cord-005453-4057qib7 11359 1 With with IN cord-005453-4057qib7 11359 2 a a DT cord-005453-4057qib7 11359 3 median median JJ cord-005453-4057qib7 11359 4 follow follow NN cord-005453-4057qib7 11359 5 of of IN cord-005453-4057qib7 11359 6 3 3 CD cord-005453-4057qib7 11359 7 years year NNS cord-005453-4057qib7 11359 8 ( ( -LRB- cord-005453-4057qib7 11359 9 1 1 CD cord-005453-4057qib7 11359 10 - - SYM cord-005453-4057qib7 11359 11 16 16 CD cord-005453-4057qib7 11359 12 years year NNS cord-005453-4057qib7 11359 13 ) ) -RRB- cord-005453-4057qib7 11359 14 , , , cord-005453-4057qib7 11359 15 10-year 10-year CD cord-005453-4057qib7 11359 16 OS os NN cord-005453-4057qib7 11359 17 was be VBD cord-005453-4057qib7 11359 18 40.4 40.4 CD cord-005453-4057qib7 11359 19 % % NN cord-005453-4057qib7 11359 20 , , , cord-005453-4057qib7 11359 21 10-year 10-year CD cord-005453-4057qib7 11359 22 non non JJ cord-005453-4057qib7 11359 23 - - JJ cord-005453-4057qib7 11359 24 relapse relapse JJ cord-005453-4057qib7 11359 25 mortality mortality NN cord-005453-4057qib7 11359 26 CI CI NNP cord-005453-4057qib7 11359 27 23.4 23.4 CD cord-005453-4057qib7 11359 28 % % NN cord-005453-4057qib7 11359 29 and and CC cord-005453-4057qib7 11359 30 10year 10year JJ cord-005453-4057qib7 11359 31 DFS DFS NNP cord-005453-4057qib7 11359 32 32 32 CD cord-005453-4057qib7 11359 33 % % NN cord-005453-4057qib7 11359 34 . . . cord-005453-4057qib7 11360 1 There there EX cord-005453-4057qib7 11360 2 was be VBD cord-005453-4057qib7 11360 3 no no DT cord-005453-4057qib7 11360 4 difference difference NN cord-005453-4057qib7 11360 5 in in IN cord-005453-4057qib7 11360 6 survival survival NN cord-005453-4057qib7 11360 7 according accord VBG cord-005453-4057qib7 11360 8 to to IN cord-005453-4057qib7 11360 9 original original JJ cord-005453-4057qib7 11360 10 disease disease NN cord-005453-4057qib7 11360 11 ( ( -LRB- cord-005453-4057qib7 11360 12 5-year 5-year CD cord-005453-4057qib7 11360 13 OS os NN cord-005453-4057qib7 11360 14 for for IN cord-005453-4057qib7 11360 15 NHL=60.2 NHL=60.2 NNP cord-005453-4057qib7 11360 16 % % NN cord-005453-4057qib7 11360 17 , , , cord-005453-4057qib7 11360 18 HL=46.7 hl=46.7 UH cord-005453-4057qib7 11360 19 % % NN cord-005453-4057qib7 11360 20 , , , cord-005453-4057qib7 11360 21 CLL=31%% CLL=31%% NNS cord-005453-4057qib7 11360 22 , , , cord-005453-4057qib7 11360 23 p=0.67 p=0.67 NNP cord-005453-4057qib7 11360 24 ) ) -RRB- cord-005453-4057qib7 11360 25 . . . cord-005453-4057qib7 11361 1 Multivariate multivariate JJ cord-005453-4057qib7 11361 2 analysis analysis NN cord-005453-4057qib7 11361 3 revealed reveal VBD cord-005453-4057qib7 11361 4 high high JJ cord-005453-4057qib7 11361 5 and and CC cord-005453-4057qib7 11361 6 very very RB cord-005453-4057qib7 11361 7 high high JJ cord-005453-4057qib7 11361 8 DRI dri NN cord-005453-4057qib7 11361 9 as as IN cord-005453-4057qib7 11361 10 the the DT cord-005453-4057qib7 11361 11 single single JJ cord-005453-4057qib7 11361 12 predicting predict VBG cord-005453-4057qib7 11361 13 factor factor NN cord-005453-4057qib7 11361 14 of of IN cord-005453-4057qib7 11361 15 OS OS NNP cord-005453-4057qib7 11361 16 ( ( -LRB- cord-005453-4057qib7 11361 17 HR HR NNP cord-005453-4057qib7 11361 18 9.69 9.69 CD cord-005453-4057qib7 11361 19 , , , cord-005453-4057qib7 11361 20 CI CI NNP cord-005453-4057qib7 11361 21 1.55 1.55 CD cord-005453-4057qib7 11361 22 - - HYPH cord-005453-4057qib7 11361 23 60.55 60.55 CD cord-005453-4057qib7 11361 24 , , , cord-005453-4057qib7 11361 25 p=0.015 p=0.015 NNPS cord-005453-4057qib7 11361 26 ) ) -RRB- cord-005453-4057qib7 11361 27 , , , cord-005453-4057qib7 11361 28 when when WRB cord-005453-4057qib7 11361 29 assessing assess VBG cord-005453-4057qib7 11361 30 impact impact NN cord-005453-4057qib7 11361 31 of of IN cord-005453-4057qib7 11361 32 disease disease NN cord-005453-4057qib7 11361 33 , , , cord-005453-4057qib7 11361 34 DRI DRI NNP cord-005453-4057qib7 11361 35 , , , cord-005453-4057qib7 11361 36 prior prior JJ cord-005453-4057qib7 11361 37 treatment treatment NN cord-005453-4057qib7 11361 38 lines line NNS cord-005453-4057qib7 11361 39 , , , cord-005453-4057qib7 11361 40 gender gender NN cord-005453-4057qib7 11361 41 and and CC cord-005453-4057qib7 11361 42 bone bone NN cord-005453-4057qib7 11361 43 marrow marrow NN cord-005453-4057qib7 11361 44 infiltration infiltration NN cord-005453-4057qib7 11361 45 at at IN cord-005453-4057qib7 11361 46 diagnosis diagnosis NN cord-005453-4057qib7 11361 47 . . . cord-005453-4057qib7 11362 1 Conclusions conclusion NNS cord-005453-4057qib7 11362 2 : : : cord-005453-4057qib7 11363 1 Our -PRON- PRP$ cord-005453-4057qib7 11363 2 data datum NNS cord-005453-4057qib7 11363 3 suggest suggest VBP cord-005453-4057qib7 11363 4 that that IN cord-005453-4057qib7 11363 5 RIC RIC NNP cord-005453-4057qib7 11363 6 allo allo NNP cord-005453-4057qib7 11363 7 - - HYPH cord-005453-4057qib7 11363 8 HCT HCT NNP cord-005453-4057qib7 11363 9 provides provide VBZ cord-005453-4057qib7 11363 10 encouraging encourage VBG cord-005453-4057qib7 11363 11 survival survival NN cord-005453-4057qib7 11363 12 rates rate NNS cord-005453-4057qib7 11363 13 , , , cord-005453-4057qib7 11363 14 potentially potentially RB cord-005453-4057qib7 11363 15 offering offer VBG cord-005453-4057qib7 11363 16 the the DT cord-005453-4057qib7 11363 17 chance chance NN cord-005453-4057qib7 11363 18 of of IN cord-005453-4057qib7 11363 19 cure cure NN cord-005453-4057qib7 11363 20 , , , cord-005453-4057qib7 11363 21 with with IN cord-005453-4057qib7 11363 22 acceptable acceptable JJ cord-005453-4057qib7 11363 23 long long JJ cord-005453-4057qib7 11363 24 - - HYPH cord-005453-4057qib7 11363 25 term term NN cord-005453-4057qib7 11363 26 mortality mortality NN cord-005453-4057qib7 11363 27 in in IN cord-005453-4057qib7 11363 28 selected select VBN cord-005453-4057qib7 11363 29 high high JJ cord-005453-4057qib7 11363 30 - - HYPH cord-005453-4057qib7 11363 31 risk risk NN cord-005453-4057qib7 11363 32 patients patient NNS cord-005453-4057qib7 11363 33 with with IN cord-005453-4057qib7 11363 34 lymphoid lymphoid JJ cord-005453-4057qib7 11363 35 neoplasms neoplasm NNS cord-005453-4057qib7 11363 36 . . . cord-005453-4057qib7 11364 1 DRI DRI NNP cord-005453-4057qib7 11364 2 that that WDT cord-005453-4057qib7 11364 3 is be VBZ cord-005453-4057qib7 11364 4 mainly mainly RB cord-005453-4057qib7 11364 5 associated associate VBN cord-005453-4057qib7 11364 6 with with IN cord-005453-4057qib7 11364 7 disease disease NN cord-005453-4057qib7 11364 8 stage stage NN cord-005453-4057qib7 11364 9 at at IN cord-005453-4057qib7 11364 10 transplant transplant NN cord-005453-4057qib7 11364 11 independently independently RB cord-005453-4057qib7 11364 12 affects affect VBZ cord-005453-4057qib7 11364 13 survival survival NN cord-005453-4057qib7 11364 14 . . . cord-005453-4057qib7 11365 1 Therefore therefore RB cord-005453-4057qib7 11365 2 , , , cord-005453-4057qib7 11365 3 continued continue VBN cord-005453-4057qib7 11365 4 efforts effort NNS cord-005453-4057qib7 11365 5 are be VBP cord-005453-4057qib7 11365 6 necessary necessary JJ cord-005453-4057qib7 11365 7 for for IN cord-005453-4057qib7 11365 8 clinical clinical JJ cord-005453-4057qib7 11365 9 application application NN cord-005453-4057qib7 11365 10 of of IN cord-005453-4057qib7 11365 11 novel novel JJ cord-005453-4057qib7 11365 12 agents agent NNS cord-005453-4057qib7 11365 13 aiming aim VBG cord-005453-4057qib7 11365 14 to to TO cord-005453-4057qib7 11365 15 lower lower VB cord-005453-4057qib7 11365 16 disease disease NN cord-005453-4057qib7 11365 17 stage stage NN cord-005453-4057qib7 11365 18 pre pre JJ cord-005453-4057qib7 11365 19 - - NN cord-005453-4057qib7 11365 20 transplant transplant NN cord-005453-4057qib7 11365 21 . . . cord-005453-4057qib7 11366 1 Disclosure disclosure NN cord-005453-4057qib7 11366 2 : : : cord-005453-4057qib7 11366 3 Nothing nothing NN cord-005453-4057qib7 11366 4 to to TO cord-005453-4057qib7 11366 5 declare declare VB cord-005453-4057qib7 11366 6 Results result NNS cord-005453-4057qib7 11366 7 : : : cord-005453-4057qib7 11367 1 Six six CD cord-005453-4057qib7 11367 2 pts pt NNS cord-005453-4057qib7 11367 3 were be VBD cord-005453-4057qib7 11367 4 identified identify VBN cord-005453-4057qib7 11367 5 , , , cord-005453-4057qib7 11367 6 with with IN cord-005453-4057qib7 11367 7 a a DT cord-005453-4057qib7 11367 8 median median JJ cord-005453-4057qib7 11367 9 age age NN cord-005453-4057qib7 11367 10 of of IN cord-005453-4057qib7 11367 11 30 30 CD cord-005453-4057qib7 11367 12 years year NNS cord-005453-4057qib7 11367 13 at at IN cord-005453-4057qib7 11367 14 diagnosis diagnosis NN cord-005453-4057qib7 11367 15 : : : cord-005453-4057qib7 11367 16 five five CD cord-005453-4057qib7 11367 17 with with IN cord-005453-4057qib7 11367 18 HL HL NNP cord-005453-4057qib7 11367 19 nodular nodular JJ cord-005453-4057qib7 11367 20 sclerosis sclerosis NN cord-005453-4057qib7 11367 21 and and CC cord-005453-4057qib7 11367 22 1 1 CD cord-005453-4057qib7 11367 23 with with IN cord-005453-4057qib7 11367 24 lymphocyte lymphocyte NN cord-005453-4057qib7 11367 25 depletion depletion NN cord-005453-4057qib7 11367 26 . . . cord-005453-4057qib7 11368 1 The the DT cord-005453-4057qib7 11368 2 median median JJ cord-005453-4057qib7 11368 3 number number NN cord-005453-4057qib7 11368 4 of of IN cord-005453-4057qib7 11368 5 therapeutic therapeutic JJ cord-005453-4057qib7 11368 6 lines line NNS cord-005453-4057qib7 11368 7 prior prior RB cord-005453-4057qib7 11368 8 to to IN cord-005453-4057qib7 11368 9 allo allo NN cord-005453-4057qib7 11368 10 - - HYPH cord-005453-4057qib7 11368 11 HSCT HSCT NNP cord-005453-4057qib7 11368 12 was be VBD cord-005453-4057qib7 11368 13 5 5 CD cord-005453-4057qib7 11368 14 [ [ -LRB- cord-005453-4057qib7 11368 15 4 4 CD cord-005453-4057qib7 11368 16 - - SYM cord-005453-4057qib7 11368 17 10 10 CD cord-005453-4057qib7 11368 18 ] ] -RRB- cord-005453-4057qib7 11368 19 ; ; : cord-005453-4057qib7 11368 20 four four CD cord-005453-4057qib7 11368 21 pts pt NNS cord-005453-4057qib7 11368 22 were be VBD cord-005453-4057qib7 11368 23 previously previously RB cord-005453-4057qib7 11368 24 treated treat VBN cord-005453-4057qib7 11368 25 with with IN cord-005453-4057qib7 11368 26 Brentuximaband Brentuximaband NNP cord-005453-4057qib7 11368 27 two two CD cord-005453-4057qib7 11368 28 pts pt NNS cord-005453-4057qib7 11368 29 had have VBD cord-005453-4057qib7 11368 30 been be VBN cord-005453-4057qib7 11368 31 submitted submit VBN cord-005453-4057qib7 11368 32 to to IN cord-005453-4057qib7 11368 33 high high JJ cord-005453-4057qib7 11368 34 dose dose NN cord-005453-4057qib7 11368 35 chemotherapy chemotherapy NN cord-005453-4057qib7 11368 36 with with IN cord-005453-4057qib7 11368 37 autologous autologous JJ cord-005453-4057qib7 11368 38 bone bone NN cord-005453-4057qib7 11368 39 marrow marrow NN cord-005453-4057qib7 11368 40 support support NN cord-005453-4057qib7 11368 41 . . . cord-005453-4057qib7 11369 1 At at IN cord-005453-4057qib7 11369 2 the the DT cord-005453-4057qib7 11369 3 time time NN cord-005453-4057qib7 11369 4 of of IN cord-005453-4057qib7 11369 5 allo allo NN cord-005453-4057qib7 11369 6 - - HYPH cord-005453-4057qib7 11369 7 HSCT HSCT NNP cord-005453-4057qib7 11369 8 , , , cord-005453-4057qib7 11369 9 4 4 CD cord-005453-4057qib7 11369 10 pts pt NNS cord-005453-4057qib7 11369 11 had have VBD cord-005453-4057qib7 11369 12 progressive progressive JJ cord-005453-4057qib7 11369 13 disease disease NN cord-005453-4057qib7 11369 14 ( ( -LRB- cord-005453-4057qib7 11369 15 DP DP NNP cord-005453-4057qib7 11369 16 ) ) -RRB- cord-005453-4057qib7 11369 17 , , , cord-005453-4057qib7 11369 18 1 1 CD cord-005453-4057qib7 11369 19 was be VBD cord-005453-4057qib7 11369 20 in in IN cord-005453-4057qib7 11369 21 partial partial JJ cord-005453-4057qib7 11369 22 response response NN cord-005453-4057qib7 11369 23 and and CC cord-005453-4057qib7 11369 24 1 1 CD cord-005453-4057qib7 11369 25 in in IN cord-005453-4057qib7 11369 26 complete complete JJ cord-005453-4057qib7 11369 27 response response NN cord-005453-4057qib7 11369 28 ( ( -LRB- cord-005453-4057qib7 11369 29 CR CR NNP cord-005453-4057qib7 11369 30 ) ) -RRB- cord-005453-4057qib7 11369 31 . . . cord-005453-4057qib7 11370 1 Five five CD cord-005453-4057qib7 11370 2 allo allo NN cord-005453-4057qib7 11370 3 - - HYPH cord-005453-4057qib7 11370 4 HSCT HSCT NNP cord-005453-4057qib7 11370 5 were be VBD cord-005453-4057qib7 11370 6 performed perform VBN cord-005453-4057qib7 11370 7 with with IN cord-005453-4057qib7 11370 8 a a DT cord-005453-4057qib7 11370 9 related related JJ cord-005453-4057qib7 11370 10 donor donor NN cord-005453-4057qib7 11370 11 , , , cord-005453-4057qib7 11370 12 4 4 CD cord-005453-4057qib7 11370 13 of of IN cord-005453-4057qib7 11370 14 wich wich WP cord-005453-4057qib7 11370 15 were be VBD cord-005453-4057qib7 11370 16 haploidentical haploidentical JJ cord-005453-4057qib7 11370 17 ( ( -LRB- cord-005453-4057qib7 11370 18 2 2 CD cord-005453-4057qib7 11370 19 parents parent NNS cord-005453-4057qib7 11370 20 , , , cord-005453-4057qib7 11370 21 1 1 CD cord-005453-4057qib7 11370 22 sibling sibling NN cord-005453-4057qib7 11370 23 and and CC cord-005453-4057qib7 11370 24 1 1 CD cord-005453-4057qib7 11370 25 descendant descendant NN cord-005453-4057qib7 11370 26 ) ) -RRB- cord-005453-4057qib7 11370 27 and and CC cord-005453-4057qib7 11370 28 1 1 CD cord-005453-4057qib7 11370 29 with with IN cord-005453-4057qib7 11370 30 an an DT cord-005453-4057qib7 11370 31 unrelated unrelated JJ cord-005453-4057qib7 11370 32 donor donor NN cord-005453-4057qib7 11370 33 ( ( -LRB- cord-005453-4057qib7 11370 34 10/10 10/10 CD cord-005453-4057qib7 11370 35 ) ) -RRB- cord-005453-4057qib7 11370 36 . . . cord-005453-4057qib7 11371 1 Prophylaxis Prophylaxis NNP cord-005453-4057qib7 11371 2 for for IN cord-005453-4057qib7 11371 3 GvHD GvHD NNP cord-005453-4057qib7 11371 4 was be VBD cord-005453-4057qib7 11371 5 performed perform VBN cord-005453-4057qib7 11371 6 with with IN cord-005453-4057qib7 11371 7 tacrolimus tacrolimus NNP cord-005453-4057qib7 11371 8 and and CC cord-005453-4057qib7 11371 9 mycophenolate mycophenolate NNP cord-005453-4057qib7 11371 10 mofetil mofetil NNP cord-005453-4057qib7 11371 11 ( ( -LRB- cord-005453-4057qib7 11371 12 with with IN cord-005453-4057qib7 11371 13 post post JJ cord-005453-4057qib7 11371 14 - - JJ cord-005453-4057qib7 11371 15 transplant transplant JJ cord-005453-4057qib7 11371 16 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 11371 17 in in IN cord-005453-4057qib7 11371 18 haploidentical haploidentical JJ cord-005453-4057qib7 11371 19 allo allo NN cord-005453-4057qib7 11371 20 - - HYPH cord-005453-4057qib7 11371 21 HSCT HSCT NNP cord-005453-4057qib7 11371 22 ) ) -RRB- cord-005453-4057qib7 11371 23 . . . cord-005453-4057qib7 11372 1 On on IN cord-005453-4057qib7 11372 2 day day NN cord-005453-4057qib7 11372 3 +100 +100 NNS cord-005453-4057qib7 11372 4 evaluations evaluation NNS cord-005453-4057qib7 11372 5 , , , cord-005453-4057qib7 11372 6 5 5 CD cord-005453-4057qib7 11372 7 pts pt NNS cord-005453-4057qib7 11372 8 had have VBD cord-005453-4057qib7 11372 9 a a DT cord-005453-4057qib7 11372 10 CR cr NN cord-005453-4057qib7 11372 11 and and CC cord-005453-4057qib7 11372 12 1 1 CD cord-005453-4057qib7 11372 13 patient patient NN cord-005453-4057qib7 11372 14 ( ( -LRB- cord-005453-4057qib7 11372 15 pt pt NN cord-005453-4057qib7 11372 16 ) ) -RRB- cord-005453-4057qib7 11372 17 had have VBD cord-005453-4057qib7 11372 18 DP dp NN cord-005453-4057qib7 11372 19 . . . cord-005453-4057qib7 11373 1 The the DT cord-005453-4057qib7 11373 2 median median JJ cord-005453-4057qib7 11373 3 time time NN cord-005453-4057qib7 11373 4 to to TO cord-005453-4057qib7 11373 5 relapse relapse VB cord-005453-4057qib7 11373 6 after after IN cord-005453-4057qib7 11373 7 allo allo NN cord-005453-4057qib7 11373 8 - - HYPH cord-005453-4057qib7 11373 9 HSCT HSCT NNP cord-005453-4057qib7 11373 10 was be VBD cord-005453-4057qib7 11373 11 of of IN cord-005453-4057qib7 11373 12 12 12 CD cord-005453-4057qib7 11373 13 months month NNS cord-005453-4057qib7 11373 14 . . . cord-005453-4057qib7 11374 1 At at IN cord-005453-4057qib7 11374 2 the the DT cord-005453-4057qib7 11374 3 time time NN cord-005453-4057qib7 11374 4 of of IN cord-005453-4057qib7 11374 5 initiation initiation NN cord-005453-4057qib7 11374 6 of of IN cord-005453-4057qib7 11374 7 nivolumab nivolumab NNP cord-005453-4057qib7 11374 8 , , , cord-005453-4057qib7 11374 9 5 5 CD cord-005453-4057qib7 11374 10 pts pt NNS cord-005453-4057qib7 11374 11 were be VBD cord-005453-4057qib7 11374 12 under under IN cord-005453-4057qib7 11374 13 steroid steroid NN cord-005453-4057qib7 11374 14 therapy therapy NN cord-005453-4057qib7 11374 15 for for IN cord-005453-4057qib7 11374 16 disease disease NNP cord-005453-4057qib7 11374 17 control control NN cord-005453-4057qib7 11374 18 , , , cord-005453-4057qib7 11374 19 without without IN cord-005453-4057qib7 11374 20 other other JJ cord-005453-4057qib7 11374 21 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 11374 22 therapy therapy NN cord-005453-4057qib7 11374 23 . . . cord-005453-4057qib7 11375 1 The the DT cord-005453-4057qib7 11375 2 median median JJ cord-005453-4057qib7 11375 3 time time NN cord-005453-4057qib7 11375 4 between between IN cord-005453-4057qib7 11375 5 allo allo NN cord-005453-4057qib7 11375 6 - - HYPH cord-005453-4057qib7 11375 7 HSCT HSCT NNP cord-005453-4057qib7 11375 8 and and CC cord-005453-4057qib7 11375 9 the the DT cord-005453-4057qib7 11375 10 beginning beginning NN cord-005453-4057qib7 11375 11 of of IN cord-005453-4057qib7 11375 12 nivolumab nivolumab NNP cord-005453-4057qib7 11375 13 was be VBD cord-005453-4057qib7 11375 14 16 16 CD cord-005453-4057qib7 11375 15 months month NNS cord-005453-4057qib7 11375 16 . . . cord-005453-4057qib7 11376 1 The the DT cord-005453-4057qib7 11376 2 initial initial JJ cord-005453-4057qib7 11376 3 dose dose NN cord-005453-4057qib7 11376 4 was be VBD cord-005453-4057qib7 11376 5 1 1 CD cord-005453-4057qib7 11376 6 mg mg NNP cord-005453-4057qib7 11376 7 / / SYM cord-005453-4057qib7 11376 8 kg kg NNP cord-005453-4057qib7 11376 9 ( ( -LRB- cord-005453-4057qib7 11376 10 associated associate VBN cord-005453-4057qib7 11376 11 with with IN cord-005453-4057qib7 11376 12 corticosteroid corticosteroid NN cord-005453-4057qib7 11376 13 therapy therapy NN cord-005453-4057qib7 11376 14 ) ) -RRB- cord-005453-4057qib7 11376 15 , , , cord-005453-4057qib7 11376 16 escalated escalate VBD cord-005453-4057qib7 11376 17 up up RP cord-005453-4057qib7 11376 18 to to TO cord-005453-4057qib7 11376 19 3 3 CD cord-005453-4057qib7 11376 20 mg mg NNP cord-005453-4057qib7 11376 21 / / SYM cord-005453-4057qib7 11376 22 kg kg NNP cord-005453-4057qib7 11376 23 biweekly biweekly NN cord-005453-4057qib7 11376 24 , , , cord-005453-4057qib7 11376 25 according accord VBG cord-005453-4057qib7 11376 26 to to IN cord-005453-4057qib7 11376 27 patient patient NN cord-005453-4057qib7 11376 28 's 's POS cord-005453-4057qib7 11376 29 tolerance tolerance NN cord-005453-4057qib7 11376 30 . . . cord-005453-4057qib7 11377 1 After after IN cord-005453-4057qib7 11377 2 the the DT cord-005453-4057qib7 11377 3 start start NN cord-005453-4057qib7 11377 4 of of IN cord-005453-4057qib7 11377 5 nivolumab nivolumab NNP cord-005453-4057qib7 11377 6 , , , cord-005453-4057qib7 11377 7 3 3 CD cord-005453-4057qib7 11377 8 patients patient NNS cord-005453-4057qib7 11377 9 , , , cord-005453-4057qib7 11377 10 with with IN cord-005453-4057qib7 11377 11 previous previous JJ cord-005453-4057qib7 11377 12 GvHD GvHD NNP cord-005453-4057qib7 11377 13 manifestations manifestation NNS cord-005453-4057qib7 11377 14 , , , cord-005453-4057qib7 11377 15 presented present VBD cord-005453-4057qib7 11377 16 a a DT cord-005453-4057qib7 11377 17 worsening worsening NN cord-005453-4057qib7 11377 18 of of IN cord-005453-4057qib7 11377 19 the the DT cord-005453-4057qib7 11377 20 cutaneous cutaneous JJ cord-005453-4057qib7 11377 21 GvHD GvHD NNP cord-005453-4057qib7 11377 22 , , , cord-005453-4057qib7 11377 23 which which WDT cord-005453-4057qib7 11377 24 required require VBD cord-005453-4057qib7 11377 25 an an DT cord-005453-4057qib7 11377 26 escalation escalation NN cord-005453-4057qib7 11377 27 of of IN cord-005453-4057qib7 11377 28 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 11377 29 therapy therapy NN cord-005453-4057qib7 11377 30 . . . cord-005453-4057qib7 11378 1 As as IN cord-005453-4057qib7 11378 2 toxicity toxicity NN cord-005453-4057qib7 11378 3 , , , cord-005453-4057qib7 11378 4 1 1 CD cord-005453-4057qib7 11378 5 pt pt NN cord-005453-4057qib7 11378 6 had have VBD cord-005453-4057qib7 11378 7 a a DT cord-005453-4057qib7 11378 8 grade grade NN cord-005453-4057qib7 11378 9 4 4 CD cord-005453-4057qib7 11378 10 pneumonitis pneumonitis NN cord-005453-4057qib7 11378 11 , , , cord-005453-4057qib7 11378 12 1 1 CD cord-005453-4057qib7 11378 13 pt pt NN cord-005453-4057qib7 11378 14 had have VBD cord-005453-4057qib7 11378 15 a a DT cord-005453-4057qib7 11378 16 grade grade NN cord-005453-4057qib7 11378 17 4 4 CD cord-005453-4057qib7 11378 18 encephalitis encephalitis NN cord-005453-4057qib7 11378 19 / / SYM cord-005453-4057qib7 11378 20 hypophysitis hypophysitis NNP cord-005453-4057qib7 11378 21 , , , cord-005453-4057qib7 11378 22 1 1 CD cord-005453-4057qib7 11378 23 pt pt NN cord-005453-4057qib7 11378 24 had have VBD cord-005453-4057qib7 11378 25 a a DT cord-005453-4057qib7 11378 26 grade grade NN cord-005453-4057qib7 11378 27 4 4 CD cord-005453-4057qib7 11378 28 pancreatitis pancreatitis NN cord-005453-4057qib7 11378 29 , , , cord-005453-4057qib7 11378 30 2 2 CD cord-005453-4057qib7 11378 31 pts pt NNS cord-005453-4057qib7 11378 32 had have VBD cord-005453-4057qib7 11378 33 headache headache NN cord-005453-4057qib7 11378 34 ( ( -LRB- cord-005453-4057qib7 11378 35 grade grade NN cord-005453-4057qib7 11378 36 1 1 CD cord-005453-4057qib7 11378 37 and and CC cord-005453-4057qib7 11378 38 3 3 CD cord-005453-4057qib7 11378 39 ) ) -RRB- cord-005453-4057qib7 11378 40 , , , cord-005453-4057qib7 11378 41 2 2 CD cord-005453-4057qib7 11378 42 pts pt NNS cord-005453-4057qib7 11378 43 had have VBD cord-005453-4057qib7 11378 44 a a DT cord-005453-4057qib7 11378 45 grade grade NN cord-005453-4057qib7 11378 46 2 2 CD cord-005453-4057qib7 11378 47 - - SYM cord-005453-4057qib7 11378 48 3 3 CD cord-005453-4057qib7 11378 49 cutaneous cutaneous JJ cord-005453-4057qib7 11378 50 reation reation NN cord-005453-4057qib7 11378 51 . . . cord-005453-4057qib7 11379 1 With with IN cord-005453-4057qib7 11379 2 a a DT cord-005453-4057qib7 11379 3 median median JJ cord-005453-4057qib7 11379 4 follow follow NN cord-005453-4057qib7 11379 5 - - HYPH cord-005453-4057qib7 11379 6 up up NN cord-005453-4057qib7 11379 7 of of IN cord-005453-4057qib7 11379 8 13 13 CD cord-005453-4057qib7 11379 9 months month NNS cord-005453-4057qib7 11379 10 since since IN cord-005453-4057qib7 11379 11 nivolumab nivolumab NNP cord-005453-4057qib7 11379 12 treatment treatment NN cord-005453-4057qib7 11379 13 , , , cord-005453-4057qib7 11379 14 the the DT cord-005453-4057qib7 11379 15 overall overall JJ cord-005453-4057qib7 11379 16 response response NN cord-005453-4057qib7 11379 17 rate rate NN cord-005453-4057qib7 11379 18 was be VBD cord-005453-4057qib7 11379 19 100 100 CD cord-005453-4057qib7 11379 20 % % NN cord-005453-4057qib7 11379 21 : : : cord-005453-4057qib7 11379 22 1 1 CD cord-005453-4057qib7 11379 23 pt pt NN cord-005453-4057qib7 11379 24 obtained obtain VBD cord-005453-4057qib7 11379 25 CR CR NNP cord-005453-4057qib7 11379 26 and and CC cord-005453-4057qib7 11379 27 5 5 CD cord-005453-4057qib7 11379 28 pts pts NN cord-005453-4057qib7 11379 29 partial partial JJ cord-005453-4057qib7 11379 30 remission remission NN cord-005453-4057qib7 11379 31 . . . cord-005453-4057qib7 11380 1 Nevertheless nevertheless RB cord-005453-4057qib7 11380 2 , , , cord-005453-4057qib7 11380 3 there there EX cord-005453-4057qib7 11380 4 were be VBD cord-005453-4057qib7 11380 5 2 2 CD cord-005453-4057qib7 11380 6 deaths death NNS cord-005453-4057qib7 11380 7 after after IN cord-005453-4057qib7 11380 8 the the DT cord-005453-4057qib7 11380 9 onset onset NN cord-005453-4057qib7 11380 10 of of IN cord-005453-4057qib7 11380 11 nivolumab nivolumab NNP cord-005453-4057qib7 11380 12 : : : cord-005453-4057qib7 11380 13 1 1 CD cord-005453-4057qib7 11380 14 pt pt NN cord-005453-4057qib7 11380 15 at at IN cord-005453-4057qib7 11380 16 4 4 CD cord-005453-4057qib7 11380 17 monts mont NNS cord-005453-4057qib7 11380 18 with with IN cord-005453-4057qib7 11380 19 DP DP NNP cord-005453-4057qib7 11380 20 and and CC cord-005453-4057qib7 11380 21 another another DT cord-005453-4057qib7 11380 22 one one CD cord-005453-4057qib7 11380 23 due due IN cord-005453-4057qib7 11380 24 to to IN cord-005453-4057qib7 11380 25 acute acute JJ cord-005453-4057qib7 11380 26 myocardial myocardial JJ cord-005453-4057qib7 11380 27 infarction infarction NN cord-005453-4057qib7 11380 28 at at IN cord-005453-4057qib7 11380 29 16 16 CD cord-005453-4057qib7 11380 30 months month NNS cord-005453-4057qib7 11380 31 . . . cord-005453-4057qib7 11381 1 At at IN cord-005453-4057qib7 11381 2 the the DT cord-005453-4057qib7 11381 3 time time NN cord-005453-4057qib7 11381 4 of of IN cord-005453-4057qib7 11381 5 analysis analysis NN cord-005453-4057qib7 11381 6 , , , cord-005453-4057qib7 11381 7 3 3 CD cord-005453-4057qib7 11381 8 pts pt NNS cord-005453-4057qib7 11381 9 maintained maintain VBD cord-005453-4057qib7 11381 10 response response NN cord-005453-4057qib7 11381 11 under under IN cord-005453-4057qib7 11381 12 nivolumab nivolumab JJ cord-005453-4057qib7 11381 13 treatment treatment NN cord-005453-4057qib7 11381 14 ( ( -LRB- cord-005453-4057qib7 11381 15 median median JJ cord-005453-4057qib7 11381 16 cycles cycle NNS cord-005453-4057qib7 11381 17 26 26 CD cord-005453-4057qib7 11381 18 ) ) -RRB- cord-005453-4057qib7 11381 19 and and CC cord-005453-4057qib7 11381 20 1 1 CD cord-005453-4057qib7 11381 21 pt pt NN cord-005453-4057qib7 11381 22 had have VBD cord-005453-4057qib7 11381 23 therapy therapy NN cord-005453-4057qib7 11381 24 suspended suspend VBN cord-005453-4057qib7 11381 25 because because IN cord-005453-4057qib7 11381 26 of of IN cord-005453-4057qib7 11381 27 toxicity toxicity NN cord-005453-4057qib7 11381 28 . . . cord-005453-4057qib7 11382 1 Conclusions conclusion NNS cord-005453-4057qib7 11382 2 : : : cord-005453-4057qib7 11383 1 These these DT cord-005453-4057qib7 11383 2 results result NNS cord-005453-4057qib7 11383 3 demonstrate demonstrate VBP cord-005453-4057qib7 11383 4 the the DT cord-005453-4057qib7 11383 5 high high JJ cord-005453-4057qib7 11383 6 probability probability NN cord-005453-4057qib7 11383 7 of of IN cord-005453-4057qib7 11383 8 achieving achieve VBG cord-005453-4057qib7 11383 9 response response NN cord-005453-4057qib7 11383 10 with with IN cord-005453-4057qib7 11383 11 nivolumab nivolumab JJ cord-005453-4057qib7 11383 12 treatment treatment NN cord-005453-4057qib7 11383 13 in in IN cord-005453-4057qib7 11383 14 patients patient NNS cord-005453-4057qib7 11383 15 with with IN cord-005453-4057qib7 11383 16 RR RR NNP cord-005453-4057qib7 11383 17 - - HYPH cord-005453-4057qib7 11383 18 HL HL NNP cord-005453-4057qib7 11383 19 relapsing relapse VBG cord-005453-4057qib7 11383 20 after after IN cord-005453-4057qib7 11383 21 allo allo NN cord-005453-4057qib7 11383 22 - - HYPH cord-005453-4057qib7 11383 23 HSCT HSCT NNP cord-005453-4057qib7 11383 24 , , , cord-005453-4057qib7 11383 25 but but CC cord-005453-4057qib7 11383 26 adverse adverse JJ cord-005453-4057qib7 11383 27 events event NNS cord-005453-4057qib7 11383 28 of of IN cord-005453-4057qib7 11383 29 grade grade NN cord-005453-4057qib7 11383 30 4 4 CD cord-005453-4057qib7 11383 31 were be VBD cord-005453-4057qib7 11383 32 frequent frequent JJ cord-005453-4057qib7 11383 33 in in IN cord-005453-4057qib7 11383 34 this this DT cord-005453-4057qib7 11383 35 small small JJ cord-005453-4057qib7 11383 36 group group NN cord-005453-4057qib7 11383 37 , , , cord-005453-4057qib7 11383 38 and and CC cord-005453-4057qib7 11383 39 the the DT cord-005453-4057qib7 11383 40 treatment treatment NN cord-005453-4057qib7 11383 41 toxicity toxicity NN cord-005453-4057qib7 11383 42 was be VBD cord-005453-4057qib7 11383 43 significant significant JJ cord-005453-4057qib7 11383 44 . . . cord-005453-4057qib7 11384 1 Disclosure disclosure NN cord-005453-4057qib7 11384 2 : : : cord-005453-4057qib7 11384 3 Nothing nothing NN cord-005453-4057qib7 11384 4 to to TO cord-005453-4057qib7 11384 5 declare declare VB cord-005453-4057qib7 11384 6 Background background NN cord-005453-4057qib7 11384 7 : : : cord-005453-4057qib7 11385 1 Intravascular Intravascular VBN cord-005453-4057qib7 11385 2 large large JJ cord-005453-4057qib7 11385 3 B b NN cord-005453-4057qib7 11385 4 - - HYPH cord-005453-4057qib7 11385 5 cell cell NN cord-005453-4057qib7 11385 6 lymphoma lymphoma NN cord-005453-4057qib7 11385 7 ( ( -LRB- cord-005453-4057qib7 11385 8 IVLBCL IVLBCL NNP cord-005453-4057qib7 11385 9 ) ) -RRB- cord-005453-4057qib7 11385 10 is be VBZ cord-005453-4057qib7 11385 11 a a DT cord-005453-4057qib7 11385 12 rare rare JJ cord-005453-4057qib7 11385 13 form form NN cord-005453-4057qib7 11385 14 of of IN cord-005453-4057qib7 11385 15 large large JJ cord-005453-4057qib7 11385 16 B b NN cord-005453-4057qib7 11385 17 - - HYPH cord-005453-4057qib7 11385 18 cell cell NN cord-005453-4057qib7 11385 19 lymphoma lymphoma NN cord-005453-4057qib7 11385 20 with with IN cord-005453-4057qib7 11385 21 pathological pathological JJ cord-005453-4057qib7 11385 22 findings finding NNS cord-005453-4057qib7 11385 23 of of IN cord-005453-4057qib7 11385 24 intravascular intravascular JJ cord-005453-4057qib7 11385 25 proliferation proliferation NN cord-005453-4057qib7 11386 1 and/or and/or CC cord-005453-4057qib7 11386 2 sinusoidal sinusoidal JJ cord-005453-4057qib7 11386 3 involvement involvement NN cord-005453-4057qib7 11386 4 of of IN cord-005453-4057qib7 11386 5 lymphoma lymphoma NN cord-005453-4057qib7 11386 6 cells cell NNS cord-005453-4057qib7 11386 7 . . . cord-005453-4057qib7 11387 1 According accord VBG cord-005453-4057qib7 11387 2 to to IN cord-005453-4057qib7 11387 3 their -PRON- PRP$ cord-005453-4057qib7 11387 4 geographic geographic JJ cord-005453-4057qib7 11387 5 distribution distribution NN cord-005453-4057qib7 11387 6 , , , cord-005453-4057qib7 11387 7 IVLBCL IVLBCL NNP cord-005453-4057qib7 11387 8 could could MD cord-005453-4057qib7 11387 9 be be VB cord-005453-4057qib7 11387 10 dichotomized dichotomize VBN cord-005453-4057qib7 11387 11 into into IN cord-005453-4057qib7 11387 12 Asian asian JJ cord-005453-4057qib7 11387 13 and and CC cord-005453-4057qib7 11387 14 Western western JJ cord-005453-4057qib7 11387 15 variants variant NNS cord-005453-4057qib7 11387 16 . . . cord-005453-4057qib7 11388 1 Compared compare VBN cord-005453-4057qib7 11388 2 with with IN cord-005453-4057qib7 11388 3 the the DT cord-005453-4057qib7 11388 4 Western western JJ cord-005453-4057qib7 11388 5 variant variant NN cord-005453-4057qib7 11388 6 , , , cord-005453-4057qib7 11388 7 where where WRB cord-005453-4057qib7 11388 8 skin skin NN cord-005453-4057qib7 11388 9 involvement involvement NN cord-005453-4057qib7 11388 10 was be VBD cord-005453-4057qib7 11388 11 common common JJ cord-005453-4057qib7 11388 12 , , , cord-005453-4057qib7 11388 13 the the DT cord-005453-4057qib7 11388 14 Asian asian JJ cord-005453-4057qib7 11388 15 variant variant NN cord-005453-4057qib7 11388 16 was be VBD cord-005453-4057qib7 11388 17 reported report VBN cord-005453-4057qib7 11388 18 to to TO cord-005453-4057qib7 11388 19 involve involve VB cord-005453-4057qib7 11388 20 more more JJR cord-005453-4057qib7 11388 21 frequently frequently RB cord-005453-4057qib7 11388 22 the the DT cord-005453-4057qib7 11388 23 liver liver NN cord-005453-4057qib7 11388 24 , , , cord-005453-4057qib7 11388 25 spleen spleen NN cord-005453-4057qib7 11388 26 and and CC cord-005453-4057qib7 11388 27 bone bone NN cord-005453-4057qib7 11388 28 marrow marrow NN cord-005453-4057qib7 11388 29 , , , cord-005453-4057qib7 11388 30 and and CC cord-005453-4057qib7 11388 31 hemophagocytic hemophagocytic JJ cord-005453-4057qib7 11388 32 lymphohistiocytosis lymphohistiocytosis NNP cord-005453-4057qib7 11388 33 is be VBZ cord-005453-4057qib7 11388 34 more more RBR cord-005453-4057qib7 11388 35 common common JJ cord-005453-4057qib7 11388 36 in in IN cord-005453-4057qib7 11388 37 Asian asian JJ cord-005453-4057qib7 11388 38 variant variant NN cord-005453-4057qib7 11388 39 . . . cord-005453-4057qib7 11389 1 Diagnosis diagnosis NN cord-005453-4057qib7 11389 2 of of IN cord-005453-4057qib7 11389 3 IVLBL IVLBL NNP cord-005453-4057qib7 11389 4 is be VBZ cord-005453-4057qib7 11389 5 still still RB cord-005453-4057qib7 11389 6 difficult difficult JJ cord-005453-4057qib7 11389 7 because because IN cord-005453-4057qib7 11389 8 of of IN cord-005453-4057qib7 11389 9 the the DT cord-005453-4057qib7 11389 10 lack lack NN cord-005453-4057qib7 11389 11 of of IN cord-005453-4057qib7 11389 12 overt overt JJ cord-005453-4057qib7 11389 13 lymphadenopathy lymphadenopathy JJ cord-005453-4057qib7 11389 14 and and CC cord-005453-4057qib7 11389 15 peripheral peripheral JJ cord-005453-4057qib7 11389 16 blood blood NN cord-005453-4057qib7 11389 17 involvement involvement NN cord-005453-4057qib7 11389 18 . . . cord-005453-4057qib7 11390 1 Thus thus RB cord-005453-4057qib7 11390 2 , , , cord-005453-4057qib7 11390 3 timely timely RB cord-005453-4057qib7 11390 4 diagnosis diagnosis NN cord-005453-4057qib7 11390 5 and and CC cord-005453-4057qib7 11390 6 immediate immediate JJ cord-005453-4057qib7 11390 7 treatment treatment NN cord-005453-4057qib7 11390 8 remain remain VBP cord-005453-4057qib7 11390 9 as as IN cord-005453-4057qib7 11390 10 a a DT cord-005453-4057qib7 11390 11 challenge challenge NN cord-005453-4057qib7 11390 12 to to TO cord-005453-4057qib7 11390 13 improve improve VB cord-005453-4057qib7 11390 14 outcomes outcome NNS cord-005453-4057qib7 11390 15 for for IN cord-005453-4057qib7 11390 16 patients patient NNS cord-005453-4057qib7 11390 17 with with IN cord-005453-4057qib7 11390 18 the the DT cord-005453-4057qib7 11390 19 Asian asian JJ cord-005453-4057qib7 11390 20 variant variant NN cord-005453-4057qib7 11390 21 . . . cord-005453-4057qib7 11391 1 Therefore therefore RB cord-005453-4057qib7 11391 2 , , , cord-005453-4057qib7 11391 3 we -PRON- PRP cord-005453-4057qib7 11391 4 analyzed analyze VBD cord-005453-4057qib7 11391 5 the the DT cord-005453-4057qib7 11391 6 clinical clinical JJ cord-005453-4057qib7 11391 7 features feature NNS cord-005453-4057qib7 11391 8 and and CC cord-005453-4057qib7 11391 9 treatment treatment NN cord-005453-4057qib7 11391 10 outcomes outcome NNS cord-005453-4057qib7 11391 11 of of IN cord-005453-4057qib7 11391 12 patients patient NNS cord-005453-4057qib7 11391 13 with with IN cord-005453-4057qib7 11391 14 the the DT cord-005453-4057qib7 11391 15 Asian asian JJ cord-005453-4057qib7 11391 16 variant variant NN cord-005453-4057qib7 11391 17 of of IN cord-005453-4057qib7 11391 18 IVLBCL IVLBCL NNP cord-005453-4057qib7 11391 19 . . . cord-005453-4057qib7 11392 1 Methods method NNS cord-005453-4057qib7 11393 1 : : : cord-005453-4057qib7 11393 2 We -PRON- PRP cord-005453-4057qib7 11393 3 analyzed analyze VBD cord-005453-4057qib7 11393 4 46 46 CD cord-005453-4057qib7 11393 5 patients patient NNS cord-005453-4057qib7 11393 6 who who WP cord-005453-4057qib7 11393 7 were be VBD cord-005453-4057qib7 11393 8 diagnosed diagnose VBN cord-005453-4057qib7 11393 9 with with IN cord-005453-4057qib7 11393 10 IVLBCL IVLBCL NNP cord-005453-4057qib7 11393 11 between between IN cord-005453-4057qib7 11393 12 2001 2001 CD cord-005453-4057qib7 11393 13 and and CC cord-005453-4057qib7 11393 14 2018 2018 CD cord-005453-4057qib7 11393 15 . . . cord-005453-4057qib7 11394 1 All all DT cord-005453-4057qib7 11394 2 patients patient NNS cord-005453-4057qib7 11394 3 were be VBD cord-005453-4057qib7 11394 4 treated treat VBN cord-005453-4057qib7 11394 5 with with IN cord-005453-4057qib7 11394 6 rituximab rituximab NN cord-005453-4057qib7 11394 7 , , , cord-005453-4057qib7 11394 8 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 11394 9 , , , cord-005453-4057qib7 11394 10 doxorubicin doxorubicin NN cord-005453-4057qib7 11394 11 , , , cord-005453-4057qib7 11394 12 vincristine vincristine NN cord-005453-4057qib7 11394 13 , , , cord-005453-4057qib7 11394 14 and and CC cord-005453-4057qib7 11394 15 prednisone prednisone NNP cord-005453-4057qib7 11394 16 ( ( -LRB- cord-005453-4057qib7 11394 17 R r NN cord-005453-4057qib7 11394 18 - - HYPH cord-005453-4057qib7 11394 19 CHOP CHOP NNP cord-005453-4057qib7 11394 20 ) ) -RRB- cord-005453-4057qib7 11394 21 . . . cord-005453-4057qib7 11395 1 Results result NNS cord-005453-4057qib7 11395 2 : : : cord-005453-4057qib7 11396 1 Forty forty CD cord-005453-4057qib7 11396 2 - - HYPH cord-005453-4057qib7 11396 3 six six CD cord-005453-4057qib7 11396 4 patients patient NNS cord-005453-4057qib7 11396 5 were be VBD cord-005453-4057qib7 11396 6 diagnosed diagnose VBN cord-005453-4057qib7 11396 7 with with IN cord-005453-4057qib7 11396 8 IVLBCL IVLBCL NNP cord-005453-4057qib7 11396 9 , , , cord-005453-4057qib7 11396 10 and and CC cord-005453-4057qib7 11396 11 their -PRON- PRP$ cord-005453-4057qib7 11396 12 median median JJ cord-005453-4057qib7 11396 13 age age NN cord-005453-4057qib7 11396 14 at at IN cord-005453-4057qib7 11396 15 diagnosis diagnosis NN cord-005453-4057qib7 11396 16 was be VBD cord-005453-4057qib7 11396 17 62 62 CD cord-005453-4057qib7 11396 18 years year NNS cord-005453-4057qib7 11396 19 ( ( -LRB- cord-005453-4057qib7 11396 20 range range NN cord-005453-4057qib7 11396 21 : : : cord-005453-4057qib7 11396 22 34 34 CD cord-005453-4057qib7 11396 23 - - SYM cord-005453-4057qib7 11396 24 82 82 CD cord-005453-4057qib7 11396 25 years year NNS cord-005453-4057qib7 11396 26 ) ) -RRB- cord-005453-4057qib7 11396 27 . . . cord-005453-4057qib7 11397 1 Male male JJ cord-005453-4057qib7 11397 2 patients patient NNS cord-005453-4057qib7 11397 3 predominated predominate VBD cord-005453-4057qib7 11397 4 ( ( -LRB- cord-005453-4057qib7 11397 5 n=26 n=26 RB cord-005453-4057qib7 11397 6 , , , cord-005453-4057qib7 11397 7 57 57 CD cord-005453-4057qib7 11397 8 % % NN cord-005453-4057qib7 11397 9 ) ) -RRB- cord-005453-4057qib7 11397 10 , , , cord-005453-4057qib7 11397 11 and and CC cord-005453-4057qib7 11397 12 B b NN cord-005453-4057qib7 11397 13 symptoms symptom NNS cord-005453-4057qib7 11397 14 were be VBD cord-005453-4057qib7 11397 15 present present JJ cord-005453-4057qib7 11397 16 in in IN cord-005453-4057qib7 11397 17 31 31 CD cord-005453-4057qib7 11397 18 patients patient NNS cord-005453-4057qib7 11397 19 ( ( -LRB- cord-005453-4057qib7 11397 20 78 78 CD cord-005453-4057qib7 11397 21 % % NN cord-005453-4057qib7 11397 22 ) ) -RRB- cord-005453-4057qib7 11397 23 . . . cord-005453-4057qib7 11398 1 Hepatomegaly Hepatomegaly NNP cord-005453-4057qib7 11398 2 and/or and/or CC cord-005453-4057qib7 11398 3 splenomegaly splenomegaly NNS cord-005453-4057qib7 11398 4 were be VBD cord-005453-4057qib7 11398 5 observed observe VBN cord-005453-4057qib7 11398 6 in in IN cord-005453-4057qib7 11398 7 26 26 CD cord-005453-4057qib7 11398 8 patients patient NNS cord-005453-4057qib7 11398 9 ( ( -LRB- cord-005453-4057qib7 11398 10 57 57 CD cord-005453-4057qib7 11398 11 % % NN cord-005453-4057qib7 11398 12 ) ) -RRB- cord-005453-4057qib7 11398 13 , , , cord-005453-4057qib7 11398 14 whereas whereas IN cord-005453-4057qib7 11398 15 lymphadenopathy lymphadenopathy JJ cord-005453-4057qib7 11398 16 was be VBD cord-005453-4057qib7 11398 17 less less RBR cord-005453-4057qib7 11398 18 common common JJ cord-005453-4057qib7 11398 19 ( ( -LRB- cord-005453-4057qib7 11398 20 n n NN cord-005453-4057qib7 11398 21 = = SYM cord-005453-4057qib7 11398 22 22 22 CD cord-005453-4057qib7 11398 23 , , , cord-005453-4057qib7 11398 24 48 48 CD cord-005453-4057qib7 11398 25 % % NN cord-005453-4057qib7 11398 26 ) ) -RRB- cord-005453-4057qib7 11398 27 . . . cord-005453-4057qib7 11399 1 Bone bone NN cord-005453-4057qib7 11399 2 marrow marrow NN cord-005453-4057qib7 11399 3 and and CC cord-005453-4057qib7 11399 4 liver liver NN cord-005453-4057qib7 11399 5 were be VBD cord-005453-4057qib7 11399 6 the the DT cord-005453-4057qib7 11399 7 most most RBS cord-005453-4057qib7 11399 8 commonly commonly RB cord-005453-4057qib7 11399 9 involved involve VBN cord-005453-4057qib7 11399 10 extranodal extranodal JJ cord-005453-4057qib7 11399 11 organs organ NNS cord-005453-4057qib7 11399 12 ( ( -LRB- cord-005453-4057qib7 11399 13 54 54 CD cord-005453-4057qib7 11399 14 % % NN cord-005453-4057qib7 11399 15 , , , cord-005453-4057qib7 11399 16 and and CC cord-005453-4057qib7 11399 17 48 48 CD cord-005453-4057qib7 11399 18 % % NN cord-005453-4057qib7 11399 19 , , , cord-005453-4057qib7 11399 20 respectively respectively RB cord-005453-4057qib7 11399 21 ) ) -RRB- cord-005453-4057qib7 11399 22 and and CC cord-005453-4057qib7 11399 23 were be VBD cord-005453-4057qib7 11399 24 the the DT cord-005453-4057qib7 11399 25 most most RBS cord-005453-4057qib7 11399 26 common common JJ cord-005453-4057qib7 11399 27 sites site NNS cord-005453-4057qib7 11399 28 of of IN cord-005453-4057qib7 11399 29 biopsy biopsy NN cord-005453-4057qib7 11399 30 for for IN cord-005453-4057qib7 11399 31 diagnosis diagnosis NN cord-005453-4057qib7 11399 32 in in IN cord-005453-4057qib7 11399 33 this this DT cord-005453-4057qib7 11399 34 study study NN cord-005453-4057qib7 11399 35 . . . cord-005453-4057qib7 11400 1 All all DT cord-005453-4057qib7 11400 2 patients patient NNS cord-005453-4057qib7 11400 3 received receive VBD cord-005453-4057qib7 11400 4 R r NN cord-005453-4057qib7 11400 5 - - HYPH cord-005453-4057qib7 11400 6 CHOP chop NN cord-005453-4057qib7 11400 7 as as IN cord-005453-4057qib7 11400 8 a a DT cord-005453-4057qib7 11400 9 first first JJ cord-005453-4057qib7 11400 10 - - HYPH cord-005453-4057qib7 11400 11 line line NN cord-005453-4057qib7 11400 12 treatment treatment NN cord-005453-4057qib7 11400 13 after after IN cord-005453-4057qib7 11400 14 diagnosis diagnosis NN cord-005453-4057qib7 11400 15 with with IN cord-005453-4057qib7 11400 16 a a DT cord-005453-4057qib7 11400 17 median median JJ cord-005453-4057qib7 11400 18 number number NN cord-005453-4057qib7 11400 19 of of IN cord-005453-4057qib7 11400 20 six six CD cord-005453-4057qib7 11400 21 cycles cycle NNS cord-005453-4057qib7 11400 22 ( ( -LRB- cord-005453-4057qib7 11400 23 range range VBP cord-005453-4057qib7 11400 24 one one CD cord-005453-4057qib7 11400 25 to to IN cord-005453-4057qib7 11400 26 eight eight CD cord-005453-4057qib7 11400 27 ) ) -RRB- cord-005453-4057qib7 11400 28 . . . cord-005453-4057qib7 11401 1 At at IN cord-005453-4057qib7 11401 2 the the DT cord-005453-4057qib7 11401 3 end end NN cord-005453-4057qib7 11401 4 of of IN cord-005453-4057qib7 11401 5 treatment treatment NN cord-005453-4057qib7 11401 6 , , , cord-005453-4057qib7 11401 7 31 31 CD cord-005453-4057qib7 11401 8 patients patient NNS cord-005453-4057qib7 11401 9 achieved achieve VBD cord-005453-4057qib7 11401 10 a a DT cord-005453-4057qib7 11401 11 complete complete JJ cord-005453-4057qib7 11401 12 response response NN cord-005453-4057qib7 11401 13 ( ( -LRB- cord-005453-4057qib7 11401 14 CR CR NNP cord-005453-4057qib7 11401 15 ) ) -RRB- cord-005453-4057qib7 11401 16 , , , cord-005453-4057qib7 11401 17 whereas whereas IN cord-005453-4057qib7 11401 18 eight eight CD cord-005453-4057qib7 11401 19 patients patient NNS cord-005453-4057qib7 11401 20 showed show VBD cord-005453-4057qib7 11401 21 progression progression NN cord-005453-4057qib7 11401 22 . . . cord-005453-4057qib7 11402 1 Six six CD cord-005453-4057qib7 11402 2 patients patient NNS cord-005453-4057qib7 11402 3 died die VBD cord-005453-4057qib7 11402 4 after after IN cord-005453-4057qib7 11402 5 the the DT cord-005453-4057qib7 11402 6 first first JJ cord-005453-4057qib7 11402 7 or or CC cord-005453-4057qib7 11402 8 second second JJ cord-005453-4057qib7 11402 9 cycle cycle NN cord-005453-4057qib7 11402 10 of of IN cord-005453-4057qib7 11402 11 R r NN cord-005453-4057qib7 11402 12 - - HYPH cord-005453-4057qib7 11402 13 CHOP chop NN cord-005453-4057qib7 11402 14 , , , cord-005453-4057qib7 11402 15 and and CC cord-005453-4057qib7 11402 16 the the DT cord-005453-4057qib7 11402 17 causes cause NNS cord-005453-4057qib7 11402 18 of of IN cord-005453-4057qib7 11402 19 death death NN cord-005453-4057qib7 11402 20 were be VBD cord-005453-4057qib7 11402 21 treatment treatment NN cord-005453-4057qib7 11402 22 - - HYPH cord-005453-4057qib7 11402 23 related relate VBN cord-005453-4057qib7 11402 24 adverse adverse JJ cord-005453-4057qib7 11402 25 events event NNS cord-005453-4057qib7 11402 26 including include VBG cord-005453-4057qib7 11402 27 cytopenia cytopenia NNP cord-005453-4057qib7 11402 28 , , , cord-005453-4057qib7 11402 29 infectious infectious JJ cord-005453-4057qib7 11402 30 complications complication NNS cord-005453-4057qib7 11402 31 , , , cord-005453-4057qib7 11402 32 and and CC cord-005453-4057qib7 11402 33 pulmonary pulmonary JJ cord-005453-4057qib7 11402 34 hemorrhage hemorrhage NN cord-005453-4057qib7 11402 35 . . . cord-005453-4057qib7 11403 1 Upfront Upfront NNP cord-005453-4057qib7 11403 2 ASCT ASCT NNP cord-005453-4057qib7 11403 3 was be VBD cord-005453-4057qib7 11403 4 done do VBN cord-005453-4057qib7 11403 5 for for IN cord-005453-4057qib7 11403 6 two two CD cord-005453-4057qib7 11403 7 patients patient NNS cord-005453-4057qib7 11403 8 including include VBG cord-005453-4057qib7 11403 9 one one CD cord-005453-4057qib7 11403 10 patient patient NN cord-005453-4057qib7 11403 11 with with IN cord-005453-4057qib7 11403 12 CNS CNS NNP cord-005453-4057qib7 11403 13 involvement involvement NN cord-005453-4057qib7 11403 14 at at IN cord-005453-4057qib7 11403 15 diagnosis diagnosis NN cord-005453-4057qib7 11403 16 , , , cord-005453-4057qib7 11403 17 and and CC cord-005453-4057qib7 11403 18 these these DT cord-005453-4057qib7 11403 19 patients patient NNS cord-005453-4057qib7 11403 20 were be VBD cord-005453-4057qib7 11403 21 still still RB cord-005453-4057qib7 11403 22 alive alive JJ cord-005453-4057qib7 11403 23 at at IN cord-005453-4057qib7 11403 24 the the DT cord-005453-4057qib7 11403 25 time time NN cord-005453-4057qib7 11403 26 of of IN cord-005453-4057qib7 11403 27 analysis analysis NN cord-005453-4057qib7 11403 28 without without IN cord-005453-4057qib7 11403 29 evidence evidence NN cord-005453-4057qib7 11403 30 of of IN cord-005453-4057qib7 11403 31 relapse relapse NN cord-005453-4057qib7 11403 32 . . . cord-005453-4057qib7 11404 1 On on IN cord-005453-4057qib7 11404 2 the the DT cord-005453-4057qib7 11404 3 other other JJ cord-005453-4057qib7 11404 4 hand hand NN cord-005453-4057qib7 11404 5 , , , cord-005453-4057qib7 11404 6 the the DT cord-005453-4057qib7 11404 7 outcome outcome NN cord-005453-4057qib7 11404 8 of of IN cord-005453-4057qib7 11404 9 six six CD cord-005453-4057qib7 11404 10 patients patient NNS cord-005453-4057qib7 11404 11 undergoing undergo VBG cord-005453-4057qib7 11404 12 salvage salvage NN cord-005453-4057qib7 11404 13 ASCT ASCT NNP cord-005453-4057qib7 11404 14 after after IN cord-005453-4057qib7 11404 15 relapse relapse NN cord-005453-4057qib7 11404 16 was be VBD cord-005453-4057qib7 11404 17 poor poor JJ cord-005453-4057qib7 11404 18 ; ; : cord-005453-4057qib7 11404 19 thus thus RB cord-005453-4057qib7 11404 20 , , , cord-005453-4057qib7 11404 21 only only RB cord-005453-4057qib7 11404 22 one one CD cord-005453-4057qib7 11404 23 patient patient NN cord-005453-4057qib7 11404 24 was be VBD cord-005453-4057qib7 11404 25 alive alive JJ cord-005453-4057qib7 11404 26 . . . cord-005453-4057qib7 11405 1 Likewise likewise RB cord-005453-4057qib7 11405 2 , , , cord-005453-4057qib7 11405 3 patients patient NNS cord-005453-4057qib7 11405 4 with with IN cord-005453-4057qib7 11405 5 disease disease NN cord-005453-4057qib7 11405 6 progression progression NN cord-005453-4057qib7 11405 7 at at IN cord-005453-4057qib7 11405 8 the the DT cord-005453-4057qib7 11405 9 end end NN cord-005453-4057qib7 11405 10 of of IN cord-005453-4057qib7 11405 11 treatment treatment NN cord-005453-4057qib7 11405 12 with with IN cord-005453-4057qib7 11405 13 R r NN cord-005453-4057qib7 11405 14 - - HYPH cord-005453-4057qib7 11405 15 CHOP CHOP NNP cord-005453-4057qib7 11405 16 showed show VBD cord-005453-4057qib7 11405 17 dismal dismal JJ cord-005453-4057qib7 11405 18 prognoses prognosis NNS cord-005453-4057qib7 11405 19 even even RB cord-005453-4057qib7 11405 20 after after IN cord-005453-4057qib7 11405 21 salvage salvage NN cord-005453-4057qib7 11405 22 chemotherapy chemotherapy NN cord-005453-4057qib7 11405 23 except except IN cord-005453-4057qib7 11405 24 for for IN cord-005453-4057qib7 11405 25 one one CD cord-005453-4057qib7 11405 26 . . . cord-005453-4057qib7 11406 1 At at IN cord-005453-4057qib7 11406 2 a a DT cord-005453-4057qib7 11406 3 median median JJ cord-005453-4057qib7 11406 4 follow follow NN cord-005453-4057qib7 11406 5 - - HYPH cord-005453-4057qib7 11406 6 up up NN cord-005453-4057qib7 11406 7 of of IN cord-005453-4057qib7 11406 8 47.0 47.0 CD cord-005453-4057qib7 11406 9 months month NNS cord-005453-4057qib7 11406 10 ( ( -LRB- cord-005453-4057qib7 11406 11 95 95 CD cord-005453-4057qib7 11406 12 % % NN cord-005453-4057qib7 11406 13 confidence confidence NN cord-005453-4057qib7 11406 14 interval interval NN cord-005453-4057qib7 11406 15 , , , cord-005453-4057qib7 11406 16 CI CI NNP cord-005453-4057qib7 11406 17 25.0 25.0 CD cord-005453-4057qib7 11406 18 - - HYPH cord-005453-4057qib7 11406 19 69.0 69.0 CD cord-005453-4057qib7 11406 20 ) ) -RRB- cord-005453-4057qib7 11406 21 , , , cord-005453-4057qib7 11406 22 the the DT cord-005453-4057qib7 11406 23 median median JJ cord-005453-4057qib7 11406 24 overall overall JJ cord-005453-4057qib7 11406 25 survival survival NN cord-005453-4057qib7 11406 26 was be VBD cord-005453-4057qib7 11406 27 45.0 45.0 CD cord-005453-4057qib7 11406 28 months month NNS cord-005453-4057qib7 11406 29 ( ( -LRB- cord-005453-4057qib7 11406 30 95 95 CD cord-005453-4057qib7 11406 31 % % NN cord-005453-4057qib7 11406 32 CI CI NNP cord-005453-4057qib7 11406 33 25.8 25.8 CD cord-005453-4057qib7 11406 34 - - HYPH cord-005453-4057qib7 11406 35 64.2 64.2 CD cord-005453-4057qib7 11406 36 ) ) -RRB- cord-005453-4057qib7 11406 37 . . . cord-005453-4057qib7 11407 1 The the DT cord-005453-4057qib7 11407 2 treatment treatment NN cord-005453-4057qib7 11407 3 outcome outcome NN cord-005453-4057qib7 11407 4 of of IN cord-005453-4057qib7 11407 5 patients patient NNS cord-005453-4057qib7 11407 6 with with IN cord-005453-4057qib7 11407 7 the the DT cord-005453-4057qib7 11407 8 Asian asian JJ cord-005453-4057qib7 11407 9 variant variant NN cord-005453-4057qib7 11407 10 of of IN cord-005453-4057qib7 11407 11 IVLBCL IVLBCL NNP cord-005453-4057qib7 11407 12 is be VBZ cord-005453-4057qib7 11407 13 still still RB cord-005453-4057qib7 11407 14 not not RB cord-005453-4057qib7 11407 15 satisfactory satisfactory JJ cord-005453-4057qib7 11407 16 . . . cord-005453-4057qib7 11408 1 Although although IN cord-005453-4057qib7 11408 2 upfront upfront JJ cord-005453-4057qib7 11408 3 autologous autologous JJ cord-005453-4057qib7 11408 4 stem stem NN cord-005453-4057qib7 11408 5 cell cell NN cord-005453-4057qib7 11408 6 transplantation transplantation NN cord-005453-4057qib7 11408 7 might may MD cord-005453-4057qib7 11408 8 be be VB cord-005453-4057qib7 11408 9 effective effective JJ cord-005453-4057qib7 11408 10 for for IN cord-005453-4057qib7 11408 11 selected select VBN cord-005453-4057qib7 11408 12 patients patient NNS cord-005453-4057qib7 11408 13 at at IN cord-005453-4057qib7 11408 14 high high JJ cord-005453-4057qib7 11408 15 - - HYPH cord-005453-4057qib7 11408 16 risk risk NN cord-005453-4057qib7 11408 17 of of IN cord-005453-4057qib7 11408 18 relapse relapse NN cord-005453-4057qib7 11408 19 , , , cord-005453-4057qib7 11408 20 its -PRON- PRP$ cord-005453-4057qib7 11408 21 role role NN cord-005453-4057qib7 11408 22 is be VBZ cord-005453-4057qib7 11408 23 still still RB cord-005453-4057qib7 11408 24 not not RB cord-005453-4057qib7 11408 25 clear clear JJ cord-005453-4057qib7 11408 26 , , , cord-005453-4057qib7 11408 27 either either RB cord-005453-4057qib7 11408 28 . . . cord-005453-4057qib7 11409 1 Thus thus RB cord-005453-4057qib7 11409 2 , , , cord-005453-4057qib7 11409 3 further further JJ cord-005453-4057qib7 11409 4 study study NN cord-005453-4057qib7 11409 5 should should MD cord-005453-4057qib7 11409 6 be be VB cord-005453-4057qib7 11409 7 warranted warrant VBN cord-005453-4057qib7 11409 8 to to TO cord-005453-4057qib7 11409 9 develop develop VB cord-005453-4057qib7 11409 10 more more JJR cord-005453-4057qib7 11409 11 effective effective JJ cord-005453-4057qib7 11409 12 strategies strategy NNS cord-005453-4057qib7 11409 13 for for IN cord-005453-4057qib7 11409 14 diagnosis diagnosis NN cord-005453-4057qib7 11409 15 and and CC cord-005453-4057qib7 11409 16 treatment treatment NN cord-005453-4057qib7 11409 17 . . . cord-005453-4057qib7 11410 1 Clinical clinical JJ cord-005453-4057qib7 11410 2 Trial Trial NNP cord-005453-4057qib7 11410 3 Registry Registry NNP cord-005453-4057qib7 11410 4 : : : cord-005453-4057qib7 11411 1 Not not RB cord-005453-4057qib7 11411 2 applicable applicable JJ cord-005453-4057qib7 11411 3 Disclosure disclosure NN cord-005453-4057qib7 11411 4 : : : cord-005453-4057qib7 11411 5 Nothing nothing NN cord-005453-4057qib7 11411 6 to to TO cord-005453-4057qib7 11411 7 disclare disclare VB cord-005453-4057qib7 11411 8 _SP cord-005453-4057qib7 11411 9 Background Background NNP cord-005453-4057qib7 11411 10 : : : cord-005453-4057qib7 11411 11 Peripheral Peripheral NNP cord-005453-4057qib7 11411 12 T t NN cord-005453-4057qib7 11411 13 - - HYPH cord-005453-4057qib7 11411 14 cell cell NN cord-005453-4057qib7 11411 15 lymphomas lymphoma NNS cord-005453-4057qib7 11411 16 ( ( -LRB- cord-005453-4057qib7 11411 17 PTCLs ptcl NNS cord-005453-4057qib7 11411 18 ) ) -RRB- cord-005453-4057qib7 11411 19 are be VBP cord-005453-4057qib7 11411 20 about about RB cord-005453-4057qib7 11411 21 10 10 CD cord-005453-4057qib7 11411 22 % % NN cord-005453-4057qib7 11411 23 of of IN cord-005453-4057qib7 11411 24 non non JJ cord-005453-4057qib7 11411 25 - - JJ cord-005453-4057qib7 11411 26 Hodgkin´s hodgkin´s JJ cord-005453-4057qib7 11411 27 lymphomas lymphoma NNS cord-005453-4057qib7 11411 28 usually usually RB cord-005453-4057qib7 11411 29 with with IN cord-005453-4057qib7 11411 30 an an DT cord-005453-4057qib7 11411 31 aggressive aggressive JJ cord-005453-4057qib7 11411 32 clinical clinical JJ cord-005453-4057qib7 11411 33 course course NN cord-005453-4057qib7 11411 34 and and CC cord-005453-4057qib7 11411 35 unfavorable unfavorable JJ cord-005453-4057qib7 11411 36 prognosis prognosis NN cord-005453-4057qib7 11411 37 . . . cord-005453-4057qib7 11412 1 Given give VBN cord-005453-4057qib7 11412 2 their -PRON- PRP$ cord-005453-4057qib7 11412 3 heterogeneity heterogeneity NN cord-005453-4057qib7 11412 4 , , , cord-005453-4057qib7 11412 5 consensus consensus NN cord-005453-4057qib7 11412 6 on on IN cord-005453-4057qib7 11412 7 the the DT cord-005453-4057qib7 11412 8 best good JJS cord-005453-4057qib7 11412 9 first first JJ cord-005453-4057qib7 11412 10 - - HYPH cord-005453-4057qib7 11412 11 line line NN cord-005453-4057qib7 11412 12 treatment treatment NN cord-005453-4057qib7 11412 13 and and CC cord-005453-4057qib7 11412 14 the the DT cord-005453-4057qib7 11412 15 role role NN cord-005453-4057qib7 11412 16 of of IN cord-005453-4057qib7 11412 17 autologous autologous JJ cord-005453-4057qib7 11412 18 / / SYM cord-005453-4057qib7 11412 19 allogeneic allogeneic IN cord-005453-4057qib7 11412 20 ( ( -LRB- cord-005453-4057qib7 11412 21 ASCT ASCT NNP cord-005453-4057qib7 11412 22 / / SYM cord-005453-4057qib7 11412 23 alloSCT alloSCT NNP cord-005453-4057qib7 11412 24 ) ) -RRB- cord-005453-4057qib7 11412 25 stem stem NN cord-005453-4057qib7 11412 26 cell cell NN cord-005453-4057qib7 11412 27 transplantation transplantation NN cord-005453-4057qib7 11412 28 as as IN cord-005453-4057qib7 11412 29 consolidation consolidation NN cord-005453-4057qib7 11412 30 is be VBZ cord-005453-4057qib7 11412 31 controversial controversial JJ cord-005453-4057qib7 11412 32 . . . cord-005453-4057qib7 11413 1 Methods method NNS cord-005453-4057qib7 11413 2 : : : cord-005453-4057qib7 11414 1 We -PRON- PRP cord-005453-4057qib7 11414 2 evaluated evaluate VBD cord-005453-4057qib7 11414 3 the the DT cord-005453-4057qib7 11414 4 overall overall JJ cord-005453-4057qib7 11414 5 survival survival NN cord-005453-4057qib7 11414 6 ( ( -LRB- cord-005453-4057qib7 11414 7 OS OS NNP cord-005453-4057qib7 11414 8 ) ) -RRB- cord-005453-4057qib7 11414 9 , , , cord-005453-4057qib7 11414 10 progression progression NN cord-005453-4057qib7 11414 11 - - HYPH cord-005453-4057qib7 11414 12 free free JJ cord-005453-4057qib7 11414 13 survival survival NN cord-005453-4057qib7 11414 14 ( ( -LRB- cord-005453-4057qib7 11414 15 PFS PFS NNP cord-005453-4057qib7 11414 16 ) ) -RRB- cord-005453-4057qib7 11414 17 and and CC cord-005453-4057qib7 11414 18 toxicities toxicity NNS cord-005453-4057qib7 11414 19 of of IN cord-005453-4057qib7 11414 20 a a DT cord-005453-4057qib7 11414 21 cohort cohort NN cord-005453-4057qib7 11414 22 of of IN cord-005453-4057qib7 11414 23 patients patient NNS cord-005453-4057qib7 11414 24 with with IN cord-005453-4057qib7 11414 25 PTCLs ptcl NNS cord-005453-4057qib7 11414 26 submitted submit VBN cord-005453-4057qib7 11414 27 to to IN cord-005453-4057qib7 11414 28 ASCT ASCT NNP cord-005453-4057qib7 11414 29 / / SYM cord-005453-4057qib7 11414 30 alloSCT alloSCT NNP cord-005453-4057qib7 11414 31 intensification intensification NN cord-005453-4057qib7 11414 32 at at IN cord-005453-4057qib7 11414 33 our -PRON- PRP$ cord-005453-4057qib7 11414 34 institution institution NN cord-005453-4057qib7 11414 35 between between IN cord-005453-4057qib7 11414 36 January January NNP cord-005453-4057qib7 11414 37 2000 2000 CD cord-005453-4057qib7 11414 38 and and CC cord-005453-4057qib7 11414 39 July July NNP cord-005453-4057qib7 11414 40 2018 2018 CD cord-005453-4057qib7 11414 41 . . . cord-005453-4057qib7 11415 1 OS OS NNP cord-005453-4057qib7 11415 2 was be VBD cord-005453-4057qib7 11415 3 calculated calculate VBN cord-005453-4057qib7 11415 4 from from IN cord-005453-4057qib7 11415 5 the the DT cord-005453-4057qib7 11415 6 date date NN cord-005453-4057qib7 11415 7 of of IN cord-005453-4057qib7 11415 8 diagnosis diagnosis NN cord-005453-4057qib7 11415 9 until until IN cord-005453-4057qib7 11415 10 death death NN cord-005453-4057qib7 11415 11 . . . cord-005453-4057qib7 11416 1 PFS PFS NNP cord-005453-4057qib7 11416 2 was be VBD cord-005453-4057qib7 11416 3 measured measure VBN cord-005453-4057qib7 11416 4 from from IN cord-005453-4057qib7 11416 5 transplant transplant NN cord-005453-4057qib7 11416 6 until until IN cord-005453-4057qib7 11416 7 relapse relapse NN cord-005453-4057qib7 11416 8 , , , cord-005453-4057qib7 11416 9 progressive progressive JJ cord-005453-4057qib7 11416 10 disease disease NN cord-005453-4057qib7 11416 11 or or CC cord-005453-4057qib7 11416 12 last last JJ cord-005453-4057qib7 11416 13 follow follow NN cord-005453-4057qib7 11416 14 - - HYPH cord-005453-4057qib7 11416 15 up up NN cord-005453-4057qib7 11416 16 . . . cord-005453-4057qib7 11417 1 OS OS NNP cord-005453-4057qib7 11417 2 and and CC cord-005453-4057qib7 11417 3 PFS PFS NNP cord-005453-4057qib7 11417 4 rates rate NNS cord-005453-4057qib7 11417 5 were be VBD cord-005453-4057qib7 11417 6 estimated estimate VBN cord-005453-4057qib7 11417 7 using use VBG cord-005453-4057qib7 11417 8 the the DT cord-005453-4057qib7 11417 9 Kaplan Kaplan NNP cord-005453-4057qib7 11417 10 - - HYPH cord-005453-4057qib7 11417 11 Meier Meier NNP cord-005453-4057qib7 11417 12 method method NN cord-005453-4057qib7 11417 13 and and CC cord-005453-4057qib7 11417 14 compared compare VBN cord-005453-4057qib7 11417 15 with with IN cord-005453-4057qib7 11417 16 the the DT cord-005453-4057qib7 11417 17 Log Log NNP cord-005453-4057qib7 11417 18 - - HYPH cord-005453-4057qib7 11417 19 Rank Rank NNP cord-005453-4057qib7 11417 20 test test NN cord-005453-4057qib7 11417 21 . . . cord-005453-4057qib7 11418 1 Results result NNS cord-005453-4057qib7 11418 2 : : : cord-005453-4057qib7 11419 1 Twenty twenty CD cord-005453-4057qib7 11419 2 - - HYPH cord-005453-4057qib7 11419 3 six six CD cord-005453-4057qib7 11419 4 patients patient NNS cord-005453-4057qib7 11419 5 were be VBD cord-005453-4057qib7 11419 6 identified identify VBN cord-005453-4057qib7 11419 7 , , , cord-005453-4057qib7 11419 8 16 16 CD cord-005453-4057qib7 11419 9 female female JJ cord-005453-4057qib7 11419 10 ( ( -LRB- cord-005453-4057qib7 11419 11 61 61 CD cord-005453-4057qib7 11419 12 % % NN cord-005453-4057qib7 11419 13 ) ) -RRB- cord-005453-4057qib7 11419 14 , , , cord-005453-4057qib7 11419 15 median median JJ cord-005453-4057qib7 11419 16 age age NN cord-005453-4057qib7 11419 17 was be VBD cord-005453-4057qib7 11419 18 46 46 CD cord-005453-4057qib7 11419 19 years year NNS cord-005453-4057qib7 11420 1 ( ( -LRB- cord-005453-4057qib7 11420 2 range range NN cord-005453-4057qib7 11420 3 : : : cord-005453-4057qib7 11420 4 22 22 CD cord-005453-4057qib7 11420 5 to to IN cord-005453-4057qib7 11420 6 62 62 CD cord-005453-4057qib7 11420 7 ) ) -RRB- cord-005453-4057qib7 11420 8 . . . cord-005453-4057qib7 11421 1 Ninetytwo Ninetytwo NNP cord-005453-4057qib7 11421 2 percent percent NN cord-005453-4057qib7 11421 3 of of IN cord-005453-4057qib7 11421 4 patients patient NNS cord-005453-4057qib7 11421 5 presented present VBN cord-005453-4057qib7 11421 6 with with IN cord-005453-4057qib7 11421 7 advanced advanced JJ cord-005453-4057qib7 11421 8 - - HYPH cord-005453-4057qib7 11421 9 stage stage NN cord-005453-4057qib7 11421 10 disease disease NN cord-005453-4057qib7 11421 11 at at IN cord-005453-4057qib7 11421 12 diagnosis diagnosis NN cord-005453-4057qib7 11421 13 ( ( -LRB- cord-005453-4057qib7 11421 14 Ann Ann NNP cord-005453-4057qib7 11421 15 Arbor Arbor NNP cord-005453-4057qib7 11421 16 stage stage NN cord-005453-4057qib7 11421 17 III III NNP cord-005453-4057qib7 11421 18 or or CC cord-005453-4057qib7 11421 19 IV IV NNP cord-005453-4057qib7 11421 20 ) ) -RRB- cord-005453-4057qib7 11421 21 , , , cord-005453-4057qib7 11421 22 38 38 CD cord-005453-4057qib7 11421 23 % % NN cord-005453-4057qib7 11421 24 with with IN cord-005453-4057qib7 11421 25 B b NN cord-005453-4057qib7 11421 26 symptoms symptom NNS cord-005453-4057qib7 11421 27 . . . cord-005453-4057qib7 11422 1 According accord VBG cord-005453-4057qib7 11422 2 to to IN cord-005453-4057qib7 11422 3 the the DT cord-005453-4057qib7 11422 4 2016 2016 CD cord-005453-4057qib7 11422 5 WHO who WP cord-005453-4057qib7 11422 6 classification classification NN cord-005453-4057qib7 11422 7 , , , cord-005453-4057qib7 11422 8 histologic histologic JJ cord-005453-4057qib7 11422 9 PTCL PTCL NNS cord-005453-4057qib7 11422 10 subtypes subtype NNS cord-005453-4057qib7 11422 11 included include VBN cord-005453-4057qib7 11422 12 angioimmunoblastic angioimmunoblastic JJ cord-005453-4057qib7 11422 13 Tcell Tcell NNP cord-005453-4057qib7 11422 14 lymphoma lymphoma NN cord-005453-4057qib7 11422 15 ( ( -LRB- cord-005453-4057qib7 11422 16 n n NN cord-005453-4057qib7 11422 17 = = SYM cord-005453-4057qib7 11422 18 12 12 CD cord-005453-4057qib7 11422 19 ) ) -RRB- cord-005453-4057qib7 11422 20 ; ; : cord-005453-4057qib7 11422 21 PTCL PTCL NNP cord-005453-4057qib7 11422 22 not not RB cord-005453-4057qib7 11422 23 otherwise otherwise RB cord-005453-4057qib7 11422 24 specified specify VBN cord-005453-4057qib7 11422 25 ( ( -LRB- cord-005453-4057qib7 11422 26 n n NN cord-005453-4057qib7 11422 27 = = SYM cord-005453-4057qib7 11422 28 6 6 CD cord-005453-4057qib7 11422 29 ) ) -RRB- cord-005453-4057qib7 11422 30 ; ; , cord-005453-4057qib7 11422 31 anaplastic anaplastic JJ cord-005453-4057qib7 11422 32 large large JJ cord-005453-4057qib7 11422 33 cell cell NN cord-005453-4057qib7 11422 34 lymphoma lymphoma NN cord-005453-4057qib7 11422 35 , , , cord-005453-4057qib7 11422 36 ALK ALK NNP cord-005453-4057qib7 11422 37 - - HYPH cord-005453-4057qib7 11422 38 negative negative JJ cord-005453-4057qib7 11422 39 ( ( -LRB- cord-005453-4057qib7 11422 40 n n NN cord-005453-4057qib7 11422 41 = = SYM cord-005453-4057qib7 11422 42 5 5 CD cord-005453-4057qib7 11422 43 ) ) -RRB- cord-005453-4057qib7 11422 44 ; ; , cord-005453-4057qib7 11422 45 anaplastic anaplastic JJ cord-005453-4057qib7 11422 46 large large JJ cord-005453-4057qib7 11422 47 cell cell NN cord-005453-4057qib7 11422 48 lymphoma lymphoma NN cord-005453-4057qib7 11422 49 , , , cord-005453-4057qib7 11422 50 ALK ALK NNP cord-005453-4057qib7 11422 51 - - HYPH cord-005453-4057qib7 11422 52 positive positive JJ cord-005453-4057qib7 11422 53 ( ( -LRB- cord-005453-4057qib7 11422 54 n n NN cord-005453-4057qib7 11422 55 = = SYM cord-005453-4057qib7 11422 56 1 1 CD cord-005453-4057qib7 11422 57 ) ) -RRB- cord-005453-4057qib7 11422 58 ; ; , cord-005453-4057qib7 11422 59 nodal nodal JJ cord-005453-4057qib7 11422 60 peripheral peripheral JJ cord-005453-4057qib7 11422 61 T t NN cord-005453-4057qib7 11422 62 - - HYPH cord-005453-4057qib7 11422 63 cell cell NN cord-005453-4057qib7 11422 64 lymphoma lymphoma NN cord-005453-4057qib7 11422 65 with with IN cord-005453-4057qib7 11422 66 TFH TFH NNP cord-005453-4057qib7 11422 67 phenotype phenotype NN cord-005453-4057qib7 11422 68 ( ( -LRB- cord-005453-4057qib7 11422 69 n n NN cord-005453-4057qib7 11422 70 = = SYM cord-005453-4057qib7 11422 71 2 2 CD cord-005453-4057qib7 11422 72 ) ) -RRB- cord-005453-4057qib7 11422 73 . . . cord-005453-4057qib7 11423 1 Extranodal Extranodal NNP cord-005453-4057qib7 11423 2 NK NK NNP cord-005453-4057qib7 11423 3 / / SYM cord-005453-4057qib7 11423 4 T t NN cord-005453-4057qib7 11423 5 - - HYPH cord-005453-4057qib7 11423 6 cell cell NN cord-005453-4057qib7 11423 7 lymphoma lymphoma NN cord-005453-4057qib7 11423 8 , , , cord-005453-4057qib7 11423 9 nasal nasal NN cord-005453-4057qib7 11423 10 type type NN cord-005453-4057qib7 11423 11 and and CC cord-005453-4057qib7 11423 12 primary primary JJ cord-005453-4057qib7 11423 13 cutaneous cutaneous JJ cord-005453-4057qib7 11423 14 subtypes subtype NNS cord-005453-4057qib7 11423 15 were be VBD cord-005453-4057qib7 11423 16 excluded exclude VBN cord-005453-4057qib7 11423 17 . . . cord-005453-4057qib7 11424 1 The the DT cord-005453-4057qib7 11424 2 ageadjusted ageadjusted JJ cord-005453-4057qib7 11424 3 IPI IPI NNP cord-005453-4057qib7 11424 4 ( ( -LRB- cord-005453-4057qib7 11424 5 aaIPI aaipi UH cord-005453-4057qib7 11424 6 ) ) -RRB- cord-005453-4057qib7 11424 7 was be VBD cord-005453-4057qib7 11424 8 low low JJ cord-005453-4057qib7 11424 9 / / SYM cord-005453-4057qib7 11424 10 intermediate intermediate JJ cord-005453-4057qib7 11424 11 low low NN cord-005453-4057qib7 11424 12 in in IN cord-005453-4057qib7 11424 13 15 15 CD cord-005453-4057qib7 11424 14 patients patient NNS cord-005453-4057qib7 11424 15 ( ( -LRB- cord-005453-4057qib7 11424 16 57 57 CD cord-005453-4057qib7 11424 17 % % NN cord-005453-4057qib7 11424 18 ) ) -RRB- cord-005453-4057qib7 11424 19 and and CC cord-005453-4057qib7 11424 20 intermediate intermediate JJ cord-005453-4057qib7 11424 21 high high JJ cord-005453-4057qib7 11424 22 / / SYM cord-005453-4057qib7 11424 23 high high JJ cord-005453-4057qib7 11424 24 in in IN cord-005453-4057qib7 11424 25 11 11 CD cord-005453-4057qib7 11424 26 patients patient NNS cord-005453-4057qib7 11424 27 ( ( -LRB- cord-005453-4057qib7 11424 28 43 43 CD cord-005453-4057qib7 11424 29 % % NN cord-005453-4057qib7 11424 30 ) ) -RRB- cord-005453-4057qib7 11424 31 . . . cord-005453-4057qib7 11425 1 Twenty twenty CD cord-005453-4057qib7 11425 2 - - HYPH cord-005453-4057qib7 11425 3 seven seven CD cord-005453-4057qib7 11425 4 transplants transplant NNS cord-005453-4057qib7 11425 5 were be VBD cord-005453-4057qib7 11425 6 performed perform VBN cord-005453-4057qib7 11425 7 ( ( -LRB- cord-005453-4057qib7 11425 8 19 19 CD cord-005453-4057qib7 11425 9 ASCT ASCT NNP cord-005453-4057qib7 11425 10 , , , cord-005453-4057qib7 11425 11 8 8 CD cord-005453-4057qib7 11425 12 alloSCT alloSCT NNP cord-005453-4057qib7 11425 13 ) ) -RRB- cord-005453-4057qib7 11425 14 ; ; : cord-005453-4057qib7 11425 15 18 18 CD cord-005453-4057qib7 11425 16 were be VBD cord-005453-4057qib7 11425 17 consolidation consolidation NN cord-005453-4057qib7 11425 18 in in IN cord-005453-4057qib7 11425 19 1st 1st JJ cord-005453-4057qib7 11425 20 response response NN cord-005453-4057qib7 11425 21 ( ( -LRB- cord-005453-4057qib7 11425 22 16 16 CD cord-005453-4057qib7 11425 23 ASCT ASCT NNP cord-005453-4057qib7 11425 24 and and CC cord-005453-4057qib7 11425 25 2 2 CD cord-005453-4057qib7 11425 26 alloSCT alloSCT NNP cord-005453-4057qib7 11425 27 ) ) -RRB- cord-005453-4057qib7 11425 28 with with IN cord-005453-4057qib7 11425 29 16 16 CD cord-005453-4057qib7 11425 30 in in IN cord-005453-4057qib7 11425 31 Complete complete JJ cord-005453-4057qib7 11425 32 Remission remission NN cord-005453-4057qib7 11425 33 ( ( -LRB- cord-005453-4057qib7 11425 34 CR CR NNP cord-005453-4057qib7 11425 35 ) ) -RRB- cord-005453-4057qib7 11425 36 and and CC cord-005453-4057qib7 11425 37 2 2 CD cord-005453-4057qib7 11425 38 in in IN cord-005453-4057qib7 11425 39 Partial partial JJ cord-005453-4057qib7 11425 40 Remission Remission NNP cord-005453-4057qib7 11425 41 ( ( -LRB- cord-005453-4057qib7 11425 42 PR PR NNP cord-005453-4057qib7 11425 43 ) ) -RRB- cord-005453-4057qib7 11425 44 . . . cord-005453-4057qib7 11426 1 Nine nine CD cord-005453-4057qib7 11426 2 transplants transplant NNS cord-005453-4057qib7 11426 3 were be VBD cord-005453-4057qib7 11426 4 performed perform VBN cord-005453-4057qib7 11426 5 as as IN cord-005453-4057qib7 11426 6 consolidation consolidation NN cord-005453-4057qib7 11426 7 of of IN cord-005453-4057qib7 11426 8 2 2 CD cord-005453-4057qib7 11426 9 nd nd NNP cord-005453-4057qib7 11426 10 response response NN cord-005453-4057qib7 11426 11 ( ( -LRB- cord-005453-4057qib7 11426 12 3 3 CD cord-005453-4057qib7 11426 13 ASCT ASCT NNP cord-005453-4057qib7 11426 14 and and CC cord-005453-4057qib7 11426 15 6 6 CD cord-005453-4057qib7 11426 16 alloSCT alloSCT NNP cord-005453-4057qib7 11426 17 ) ) -RRB- cord-005453-4057qib7 11426 18 with with IN cord-005453-4057qib7 11426 19 4 4 CD cord-005453-4057qib7 11426 20 in in IN cord-005453-4057qib7 11426 21 CR CR NNP cord-005453-4057qib7 11426 22 and and CC cord-005453-4057qib7 11426 23 5 5 CD cord-005453-4057qib7 11426 24 PR pr NN cord-005453-4057qib7 11426 25 . . . cord-005453-4057qib7 11427 1 In in IN cord-005453-4057qib7 11427 2 1 1 CD cord-005453-4057qib7 11427 3 patient patient NN cord-005453-4057qib7 11427 4 alloSCT alloSCT NNP cord-005453-4057qib7 11427 5 was be VBD cord-005453-4057qib7 11427 6 performed perform VBN cord-005453-4057qib7 11427 7 after after IN cord-005453-4057qib7 11427 8 ASCT ASCT NNP cord-005453-4057qib7 11427 9 , , , cord-005453-4057qib7 11427 10 due due JJ cord-005453-4057qib7 11427 11 to to IN cord-005453-4057qib7 11427 12 early early JJ cord-005453-4057qib7 11427 13 relapse relapse NN cord-005453-4057qib7 11427 14 ( ( -LRB- cord-005453-4057qib7 11427 15 < < NNP cord-005453-4057qib7 11427 16 12 12 CD cord-005453-4057qib7 11427 17 months month NNS cord-005453-4057qib7 11427 18 ) ) -RRB- cord-005453-4057qib7 11427 19 . . . cord-005453-4057qib7 11428 1 BEAM BEAM NNP cord-005453-4057qib7 11428 2 regimen regimen NN cord-005453-4057qib7 11428 3 was be VBD cord-005453-4057qib7 11428 4 used use VBN cord-005453-4057qib7 11428 5 in in IN cord-005453-4057qib7 11428 6 ASCT ASCT NNP cord-005453-4057qib7 11428 7 as as IN cord-005453-4057qib7 11428 8 conditioning conditioning NN cord-005453-4057qib7 11428 9 and and CC cord-005453-4057qib7 11428 10 FluMEL flumel NN cord-005453-4057qib7 11428 11 in in IN cord-005453-4057qib7 11428 12 alloSCT alloSCT NNP cord-005453-4057qib7 11428 13 . . . cord-005453-4057qib7 11429 1 All all DT cord-005453-4057qib7 11429 2 patients patient NNS cord-005453-4057qib7 11429 3 engrafted engraft VBD cord-005453-4057qib7 11429 4 , , , cord-005453-4057qib7 11429 5 the the DT cord-005453-4057qib7 11429 6 median median JJ cord-005453-4057qib7 11429 7 time time NN cord-005453-4057qib7 11429 8 to to IN cord-005453-4057qib7 11429 9 leukocyte leukocyte NN cord-005453-4057qib7 11429 10 recovery recovery NN cord-005453-4057qib7 11430 1 > > XX cord-005453-4057qib7 11431 1 1,000 1,000 CD cord-005453-4057qib7 11432 1 /μL /μL : cord-005453-4057qib7 11432 2 was be VBD cord-005453-4057qib7 11432 3 14 14 CD cord-005453-4057qib7 11432 4 days day NNS cord-005453-4057qib7 11432 5 ( ( -LRB- cord-005453-4057qib7 11432 6 range range NN cord-005453-4057qib7 11432 7 , , , cord-005453-4057qib7 11432 8 11 11 CD cord-005453-4057qib7 11432 9 to to TO cord-005453-4057qib7 11432 10 25 25 CD cord-005453-4057qib7 11432 11 ) ) -RRB- cord-005453-4057qib7 11432 12 . . . cord-005453-4057qib7 11433 1 Four four CD cord-005453-4057qib7 11433 2 of of IN cord-005453-4057qib7 11433 3 the the DT cord-005453-4057qib7 11433 4 8 8 CD cord-005453-4057qib7 11433 5 pts pts NN cord-005453-4057qib7 11433 6 ( ( -LRB- cord-005453-4057qib7 11433 7 50 50 CD cord-005453-4057qib7 11433 8 % % NN cord-005453-4057qib7 11433 9 ) ) -RRB- cord-005453-4057qib7 11433 10 , , , cord-005453-4057qib7 11433 11 submitted submit VBN cord-005453-4057qib7 11433 12 to to IN cord-005453-4057qib7 11433 13 alloSCT alloSCT NNP cord-005453-4057qib7 11433 14 had have VBD cord-005453-4057qib7 11433 15 chronic chronic JJ cord-005453-4057qib7 11433 16 graft graft NN cord-005453-4057qib7 11433 17 versus versus IN cord-005453-4057qib7 11433 18 host host NN cord-005453-4057qib7 11433 19 disease disease NN cord-005453-4057qib7 11433 20 which which WDT cord-005453-4057qib7 11433 21 was be VBD cord-005453-4057qib7 11433 22 the the DT cord-005453-4057qib7 11433 23 most most RBS cord-005453-4057qib7 11433 24 relevant relevant JJ cord-005453-4057qib7 11433 25 complication complication NN cord-005453-4057qib7 11433 26 of of IN cord-005453-4057qib7 11433 27 this this DT cord-005453-4057qib7 11433 28 analysis analysis NN cord-005453-4057qib7 11433 29 . . . cord-005453-4057qib7 11434 1 Considering consider VBG cord-005453-4057qib7 11434 2 the the DT cord-005453-4057qib7 11434 3 whole whole JJ cord-005453-4057qib7 11434 4 cohort cohort NN cord-005453-4057qib7 11434 5 , , , cord-005453-4057qib7 11434 6 the the DT cord-005453-4057qib7 11434 7 median median JJ cord-005453-4057qib7 11434 8 follow follow NN cord-005453-4057qib7 11434 9 - - HYPH cord-005453-4057qib7 11434 10 up up NN cord-005453-4057qib7 11434 11 was be VBD cord-005453-4057qib7 11434 12 50.5 50.5 CD cord-005453-4057qib7 11434 13 months month NNS cord-005453-4057qib7 11434 14 ( ( -LRB- cord-005453-4057qib7 11434 15 range range NN cord-005453-4057qib7 11434 16 , , , cord-005453-4057qib7 11434 17 2 2 CD cord-005453-4057qib7 11434 18 to to IN cord-005453-4057qib7 11434 19 217 217 CD cord-005453-4057qib7 11434 20 ) ) -RRB- cord-005453-4057qib7 11434 21 . . . cord-005453-4057qib7 11435 1 The the DT cord-005453-4057qib7 11435 2 estimated estimate VBN cord-005453-4057qib7 11435 3 5-year 5-year CD cord-005453-4057qib7 11435 4 OS OS NNP cord-005453-4057qib7 11435 5 and and CC cord-005453-4057qib7 11435 6 PFS PFS NNP cord-005453-4057qib7 11435 7 were be VBD cord-005453-4057qib7 11435 8 77 77 CD cord-005453-4057qib7 11435 9 % % NN cord-005453-4057qib7 11435 10 and and CC cord-005453-4057qib7 11435 11 39 39 CD cord-005453-4057qib7 11435 12 % % NN cord-005453-4057qib7 11435 13 , , , cord-005453-4057qib7 11435 14 respectively respectively RB cord-005453-4057qib7 11435 15 . . . cord-005453-4057qib7 11436 1 Seven seven CD cord-005453-4057qib7 11436 2 patients patient NNS cord-005453-4057qib7 11436 3 relapsed relapse VBD cord-005453-4057qib7 11436 4 ( ( -LRB- cord-005453-4057qib7 11436 5 6 6 CD cord-005453-4057qib7 11436 6 early early JJ cord-005453-4057qib7 11436 7 ) ) -RRB- cord-005453-4057qib7 11436 8 all all DT cord-005453-4057qib7 11436 9 after after IN cord-005453-4057qib7 11436 10 ASCT ASCT NNP cord-005453-4057qib7 11436 11 , , , cord-005453-4057qib7 11436 12 there there EX cord-005453-4057qib7 11436 13 were be VBD cord-005453-4057qib7 11436 14 no no DT cord-005453-4057qib7 11436 15 relapses relapse NNS cord-005453-4057qib7 11436 16 after after IN cord-005453-4057qib7 11436 17 alloSCT alloSCT NNP cord-005453-4057qib7 11436 18 , , , cord-005453-4057qib7 11436 19 however however RB cord-005453-4057qib7 11436 20 , , , cord-005453-4057qib7 11436 21 the the DT cord-005453-4057qib7 11436 22 results result NNS cord-005453-4057qib7 11436 23 were be VBD cord-005453-4057qib7 11436 24 not not RB cord-005453-4057qib7 11436 25 statistically statistically RB cord-005453-4057qib7 11436 26 significant significant JJ cord-005453-4057qib7 11436 27 between between IN cord-005453-4057qib7 11436 28 the the DT cord-005453-4057qib7 11436 29 alloSCT alloSCT NNP cord-005453-4057qib7 11436 30 and and CC cord-005453-4057qib7 11436 31 ASCT ASCT NNP cord-005453-4057qib7 11436 32 groups group NNS cord-005453-4057qib7 11436 33 ; ; : cord-005453-4057qib7 11436 34 the the DT cord-005453-4057qib7 11436 35 5-year 5-year CD cord-005453-4057qib7 11436 36 OS OS NNP cord-005453-4057qib7 11436 37 rates rate NNS cord-005453-4057qib7 11436 38 were be VBD cord-005453-4057qib7 11436 39 87 87 CD cord-005453-4057qib7 11436 40 % % NN cord-005453-4057qib7 11436 41 and and CC cord-005453-4057qib7 11436 42 62 62 CD cord-005453-4057qib7 11436 43 % % NN cord-005453-4057qib7 11436 44 ( ( -LRB- cord-005453-4057qib7 11436 45 p p NN cord-005453-4057qib7 11436 46 = = SYM cord-005453-4057qib7 11436 47 0,16 0,16 NN cord-005453-4057qib7 11436 48 ) ) -RRB- cord-005453-4057qib7 11437 1 and and CC cord-005453-4057qib7 11437 2 the the DT cord-005453-4057qib7 11437 3 5year 5year JJ cord-005453-4057qib7 11437 4 PFS PFS NNP cord-005453-4057qib7 11437 5 rates rate NNS cord-005453-4057qib7 11437 6 were be VBD cord-005453-4057qib7 11437 7 85 85 CD cord-005453-4057qib7 11437 8 % % NN cord-005453-4057qib7 11437 9 and and CC cord-005453-4057qib7 11437 10 59 59 CD cord-005453-4057qib7 11437 11 % % NN cord-005453-4057qib7 11437 12 ( ( -LRB- cord-005453-4057qib7 11437 13 p p NN cord-005453-4057qib7 11437 14 = = SYM cord-005453-4057qib7 11437 15 0,26 0,26 CD cord-005453-4057qib7 11437 16 ) ) -RRB- cord-005453-4057qib7 11437 17 respectively respectively RB cord-005453-4057qib7 11437 18 . . . cord-005453-4057qib7 11438 1 For for IN cord-005453-4057qib7 11438 2 the the DT cord-005453-4057qib7 11438 3 all all DT cord-005453-4057qib7 11438 4 patients patient NNS cord-005453-4057qib7 11438 5 treatment treatment NN cord-005453-4057qib7 11438 6 - - HYPH cord-005453-4057qib7 11438 7 related relate VBN cord-005453-4057qib7 11438 8 mortality mortality NN cord-005453-4057qib7 11438 9 ( ( -LRB- cord-005453-4057qib7 11438 10 TRM TRM NNP cord-005453-4057qib7 11438 11 ) ) -RRB- cord-005453-4057qib7 11438 12 was be VBD cord-005453-4057qib7 11438 13 3,7 3,7 CD cord-005453-4057qib7 11438 14 % % NN cord-005453-4057qib7 11438 15 ; ; : cord-005453-4057qib7 11438 16 7 7 CD cord-005453-4057qib7 11438 17 patients patient NNS cord-005453-4057qib7 11438 18 died die VBD cord-005453-4057qib7 11438 19 , , , cord-005453-4057qib7 11438 20 6 6 CD cord-005453-4057qib7 11438 21 with with IN cord-005453-4057qib7 11438 22 progressive progressive JJ cord-005453-4057qib7 11438 23 disease disease NN cord-005453-4057qib7 11438 24 ( ( -LRB- cord-005453-4057qib7 11438 25 ASCT ASCT NNP cord-005453-4057qib7 11438 26 ) ) -RRB- cord-005453-4057qib7 11438 27 and and CC cord-005453-4057qib7 11438 28 1 1 CD cord-005453-4057qib7 11438 29 for for IN cord-005453-4057qib7 11438 30 hepatic hepatic JJ cord-005453-4057qib7 11438 31 toxicity toxicity NN cord-005453-4057qib7 11438 32 ( ( -LRB- cord-005453-4057qib7 11438 33 alloSCT alloSCT NNP cord-005453-4057qib7 11438 34 ) ) -RRB- cord-005453-4057qib7 11438 35 before before IN cord-005453-4057qib7 11438 36 D+100 D+100 NNS cord-005453-4057qib7 11438 37 . . . cord-005453-4057qib7 11439 1 Conclusions conclusion NNS cord-005453-4057qib7 11439 2 : : : cord-005453-4057qib7 11440 1 The the DT cord-005453-4057qib7 11440 2 results result NNS cord-005453-4057qib7 11440 3 of of IN cord-005453-4057qib7 11440 4 this this DT cord-005453-4057qib7 11440 5 retrospective retrospective JJ cord-005453-4057qib7 11440 6 study study NN cord-005453-4057qib7 11440 7 , , , cord-005453-4057qib7 11440 8 taking take VBG cord-005453-4057qib7 11440 9 into into IN cord-005453-4057qib7 11440 10 account account NN cord-005453-4057qib7 11440 11 the the DT cord-005453-4057qib7 11440 12 adverse adverse JJ cord-005453-4057qib7 11440 13 risk risk NN cord-005453-4057qib7 11440 14 profile profile NN cord-005453-4057qib7 11440 15 of of IN cord-005453-4057qib7 11440 16 the the DT cord-005453-4057qib7 11440 17 population population NN cord-005453-4057qib7 11440 18 , , , cord-005453-4057qib7 11440 19 suggest suggest VBP cord-005453-4057qib7 11440 20 that that IN cord-005453-4057qib7 11440 21 autologous autologous JJ cord-005453-4057qib7 11440 22 / / SYM cord-005453-4057qib7 11440 23 allogeneic allogeneic IN cord-005453-4057qib7 11440 24 stem stem NN cord-005453-4057qib7 11440 25 cell cell NN cord-005453-4057qib7 11440 26 transplantation transplantation NN cord-005453-4057qib7 11440 27 as as IN cord-005453-4057qib7 11440 28 an an DT cord-005453-4057qib7 11440 29 effective effective JJ cord-005453-4057qib7 11440 30 and and CC cord-005453-4057qib7 11440 31 safe safe JJ cord-005453-4057qib7 11440 32 option option NN cord-005453-4057qib7 11440 33 for for IN cord-005453-4057qib7 11440 34 the the DT cord-005453-4057qib7 11440 35 consolidation consolidation NN cord-005453-4057qib7 11440 36 of of IN cord-005453-4057qib7 11440 37 patients patient NNS cord-005453-4057qib7 11440 38 with with IN cord-005453-4057qib7 11440 39 PTCLs ptcl NNS cord-005453-4057qib7 11440 40 . . . cord-005453-4057qib7 11441 1 These these DT cord-005453-4057qib7 11441 2 results result NNS cord-005453-4057qib7 11441 3 need need VBP cord-005453-4057qib7 11441 4 to to TO cord-005453-4057qib7 11441 5 be be VB cord-005453-4057qib7 11441 6 validated validate VBN cord-005453-4057qib7 11441 7 in in IN cord-005453-4057qib7 11441 8 prospective prospective JJ cord-005453-4057qib7 11441 9 studies study NNS cord-005453-4057qib7 11441 10 , , , cord-005453-4057qib7 11441 11 including include VBG cord-005453-4057qib7 11441 12 a a DT cord-005453-4057qib7 11441 13 larger large JJR cord-005453-4057qib7 11441 14 number number NN cord-005453-4057qib7 11441 15 of of IN cord-005453-4057qib7 11441 16 patients patient NNS cord-005453-4057qib7 11441 17 . . . cord-005453-4057qib7 11442 1 Disclosure disclosure NN cord-005453-4057qib7 11442 2 Background background NN cord-005453-4057qib7 11442 3 : : : cord-005453-4057qib7 11443 1 Autologous autologous JJ cord-005453-4057qib7 11443 2 stem stem NN cord-005453-4057qib7 11443 3 cell cell NN cord-005453-4057qib7 11443 4 transplantation transplantation NN cord-005453-4057qib7 11443 5 is be VBZ cord-005453-4057qib7 11443 6 used use VBN cord-005453-4057qib7 11443 7 as as IN cord-005453-4057qib7 11443 8 consolidation consolidation NN cord-005453-4057qib7 11443 9 therapy therapy NN cord-005453-4057qib7 11443 10 in in IN cord-005453-4057qib7 11443 11 relapsed relapse VBN cord-005453-4057qib7 11443 12 lymphoma lymphoma NN cord-005453-4057qib7 11443 13 patients patient NNS cord-005453-4057qib7 11443 14 . . . cord-005453-4057qib7 11444 1 However however RB cord-005453-4057qib7 11444 2 , , , cord-005453-4057qib7 11444 3 outcome outcome NN cord-005453-4057qib7 11444 4 of of IN cord-005453-4057qib7 11444 5 lymphoma lymphoma NN cord-005453-4057qib7 11444 6 patients patient NNS cord-005453-4057qib7 11444 7 relapsing relapse VBG cord-005453-4057qib7 11444 8 after after IN cord-005453-4057qib7 11444 9 autologous autologous JJ cord-005453-4057qib7 11444 10 stem stem NN cord-005453-4057qib7 11444 11 cell cell NN cord-005453-4057qib7 11444 12 transplantation transplantation NN cord-005453-4057qib7 11444 13 is be VBZ cord-005453-4057qib7 11444 14 poor poor JJ cord-005453-4057qib7 11444 15 and and CC cord-005453-4057qib7 11444 16 allogeneic allogeneic IN cord-005453-4057qib7 11444 17 stem stem NN cord-005453-4057qib7 11444 18 cell cell NN cord-005453-4057qib7 11444 19 transplantation transplantation NN cord-005453-4057qib7 11444 20 which which WDT cord-005453-4057qib7 11444 21 can can MD cord-005453-4057qib7 11444 22 be be VB cord-005453-4057qib7 11444 23 curative curative JJ cord-005453-4057qib7 11444 24 is be VBZ cord-005453-4057qib7 11444 25 used use VBN cord-005453-4057qib7 11444 26 in in IN cord-005453-4057qib7 11444 27 the the DT cord-005453-4057qib7 11444 28 transplant transplant NN cord-005453-4057qib7 11444 29 eligible eligible JJ cord-005453-4057qib7 11444 30 patients patient NNS cord-005453-4057qib7 11444 31 in in IN cord-005453-4057qib7 11444 32 this this DT cord-005453-4057qib7 11444 33 setting setting NN cord-005453-4057qib7 11444 34 . . . cord-005453-4057qib7 11445 1 Besides besides RB cord-005453-4057qib7 11445 2 , , , cord-005453-4057qib7 11445 3 allogeneic allogeneic IN cord-005453-4057qib7 11445 4 stem stem NN cord-005453-4057qib7 11445 5 cell cell NN cord-005453-4057qib7 11445 6 transplantation transplantation NN cord-005453-4057qib7 11445 7 can can MD cord-005453-4057qib7 11445 8 be be VB cord-005453-4057qib7 11445 9 an an DT cord-005453-4057qib7 11445 10 option option NN cord-005453-4057qib7 11445 11 before before IN cord-005453-4057qib7 11445 12 autologous autologous JJ cord-005453-4057qib7 11445 13 stem stem NN cord-005453-4057qib7 11445 14 cell cell NN cord-005453-4057qib7 11445 15 transplantation transplantation NN cord-005453-4057qib7 11445 16 in in IN cord-005453-4057qib7 11445 17 some some DT cord-005453-4057qib7 11445 18 high high JJ cord-005453-4057qib7 11445 19 risk risk NN cord-005453-4057qib7 11445 20 patients patient NNS cord-005453-4057qib7 11445 21 . . . cord-005453-4057qib7 11446 1 In in IN cord-005453-4057qib7 11446 2 this this DT cord-005453-4057qib7 11446 3 study study NN cord-005453-4057qib7 11446 4 , , , cord-005453-4057qib7 11446 5 we -PRON- PRP cord-005453-4057qib7 11446 6 aimed aim VBD cord-005453-4057qib7 11446 7 to to TO cord-005453-4057qib7 11446 8 compare compare VB cord-005453-4057qib7 11446 9 the the DT cord-005453-4057qib7 11446 10 survival survival NN cord-005453-4057qib7 11446 11 rates rate NNS cord-005453-4057qib7 11446 12 of of IN cord-005453-4057qib7 11446 13 lymphoma lymphoma NN cord-005453-4057qib7 11446 14 patients patient NNS cord-005453-4057qib7 11446 15 older old JJR cord-005453-4057qib7 11446 16 than than IN cord-005453-4057qib7 11446 17 60 60 CD cord-005453-4057qib7 11446 18 years year NNS cord-005453-4057qib7 11446 19 of of IN cord-005453-4057qib7 11446 20 age age NN cord-005453-4057qib7 11446 21 and and CC cord-005453-4057qib7 11446 22 patients patient NNS cord-005453-4057qib7 11446 23 aged aged JJ cord-005453-4057qib7 11446 24 50 50 CD cord-005453-4057qib7 11446 25 - - SYM cord-005453-4057qib7 11446 26 60 60 CD cord-005453-4057qib7 11446 27 who who WP cord-005453-4057qib7 11446 28 had have VBD cord-005453-4057qib7 11446 29 undergone undergo VBN cord-005453-4057qib7 11446 30 allogeneic allogeneic NN cord-005453-4057qib7 11446 31 transplantation transplantation NN cord-005453-4057qib7 11446 32 in in IN cord-005453-4057qib7 11446 33 our -PRON- PRP$ cord-005453-4057qib7 11446 34 center center NN cord-005453-4057qib7 11446 35 . . . cord-005453-4057qib7 11447 1 Methods method NNS cord-005453-4057qib7 11447 2 : : : cord-005453-4057qib7 11447 3 We -PRON- PRP cord-005453-4057qib7 11447 4 collected collect VBD cord-005453-4057qib7 11447 5 the the DT cord-005453-4057qib7 11447 6 data datum NNS cord-005453-4057qib7 11447 7 of of IN cord-005453-4057qib7 11447 8 lymphoma lymphoma NN cord-005453-4057qib7 11447 9 patients patient NNS cord-005453-4057qib7 11447 10 older old JJR cord-005453-4057qib7 11447 11 than than IN cord-005453-4057qib7 11447 12 50 50 CD cord-005453-4057qib7 11447 13 years year NNS cord-005453-4057qib7 11447 14 of of IN cord-005453-4057qib7 11447 15 age age NN cord-005453-4057qib7 11447 16 who who WP cord-005453-4057qib7 11447 17 had have VBD cord-005453-4057qib7 11447 18 undergone undergo VBN cord-005453-4057qib7 11447 19 allogeneic allogeneic NN cord-005453-4057qib7 11447 20 transplantation transplantation NN cord-005453-4057qib7 11447 21 in in IN cord-005453-4057qib7 11447 22 our -PRON- PRP$ cord-005453-4057qib7 11447 23 center center NN cord-005453-4057qib7 11447 24 and and CC cord-005453-4057qib7 11447 25 analyzed analyze VBD cord-005453-4057qib7 11447 26 the the DT cord-005453-4057qib7 11447 27 results result NNS cord-005453-4057qib7 11447 28 by by IN cord-005453-4057qib7 11447 29 grouping group VBG cord-005453-4057qib7 11447 30 them -PRON- PRP cord-005453-4057qib7 11447 31 into into IN cord-005453-4057qib7 11447 32 2 2 CD cord-005453-4057qib7 11447 33 , , , cord-005453-4057qib7 11447 34 namely namely RB cord-005453-4057qib7 11447 35 the the DT cord-005453-4057qib7 11447 36 ones one NNS cord-005453-4057qib7 11447 37 between between IN cord-005453-4057qib7 11447 38 50 50 CD cord-005453-4057qib7 11447 39 - - SYM cord-005453-4057qib7 11447 40 60 60 CD cord-005453-4057qib7 11447 41 years year NNS cord-005453-4057qib7 11447 42 of of IN cord-005453-4057qib7 11447 43 age age NN cord-005453-4057qib7 11447 44 and and CC cord-005453-4057qib7 11447 45 the the DT cord-005453-4057qib7 11447 46 ones one NNS cord-005453-4057qib7 11447 47 over over IN cord-005453-4057qib7 11447 48 60 60 CD cord-005453-4057qib7 11447 49 years year NNS cord-005453-4057qib7 11447 50 of of IN cord-005453-4057qib7 11447 51 age age NN cord-005453-4057qib7 11447 52 . . . cord-005453-4057qib7 11448 1 [ [ -LRB- cord-005453-4057qib7 11448 2 [ [ -LRB- cord-005453-4057qib7 11448 3 P506 P506 NNP cord-005453-4057qib7 11448 4 Image image NN cord-005453-4057qib7 11448 5 ] ] -RRB- cord-005453-4057qib7 11448 6 1 1 CD cord-005453-4057qib7 11448 7 . . . cord-005453-4057qib7 11449 1 Figure figure NN cord-005453-4057qib7 11449 2 1 1 CD cord-005453-4057qib7 11449 3 Results result NNS cord-005453-4057qib7 11450 1 : : : cord-005453-4057qib7 11450 2 There there EX cord-005453-4057qib7 11450 3 were be VBD cord-005453-4057qib7 11450 4 42 42 CD cord-005453-4057qib7 11450 5 patients patient NNS cord-005453-4057qib7 11450 6 over over IN cord-005453-4057qib7 11450 7 the the DT cord-005453-4057qib7 11450 8 age age NN cord-005453-4057qib7 11450 9 of of IN cord-005453-4057qib7 11450 10 50 50 CD cord-005453-4057qib7 11450 11 who who WP cord-005453-4057qib7 11450 12 had have VBD cord-005453-4057qib7 11450 13 undergone undergo VBN cord-005453-4057qib7 11450 14 allogeneic allogeneic IN cord-005453-4057qib7 11450 15 stem stem NN cord-005453-4057qib7 11450 16 cell cell NN cord-005453-4057qib7 11450 17 trasplantation trasplantation NN cord-005453-4057qib7 11450 18 with with IN cord-005453-4057qib7 11450 19 the the DT cord-005453-4057qib7 11450 20 diagnosis diagnosis NN cord-005453-4057qib7 11450 21 of of IN cord-005453-4057qib7 11450 22 lmphoma lmphoma NNP cord-005453-4057qib7 11450 23 between between IN cord-005453-4057qib7 11450 24 2011 2011 CD cord-005453-4057qib7 11450 25 and and CC cord-005453-4057qib7 11450 26 2018 2018 CD cord-005453-4057qib7 11450 27 . . . cord-005453-4057qib7 11451 1 18 18 CD cord-005453-4057qib7 11451 2 of of IN cord-005453-4057qib7 11451 3 these these DT cord-005453-4057qib7 11451 4 patients patient NNS cord-005453-4057qib7 11451 5 were be VBD cord-005453-4057qib7 11451 6 over over IN cord-005453-4057qib7 11451 7 60 60 CD cord-005453-4057qib7 11451 8 years year NNS cord-005453-4057qib7 11451 9 of of IN cord-005453-4057qib7 11451 10 age age NN cord-005453-4057qib7 11451 11 . . . cord-005453-4057qib7 11452 1 37 37 CD cord-005453-4057qib7 11452 2 patients patient NNS cord-005453-4057qib7 11452 3 had have VBD cord-005453-4057qib7 11452 4 Non Non NNP cord-005453-4057qib7 11452 5 - - JJ cord-005453-4057qib7 11452 6 Hodgkin Hodgkin NNP cord-005453-4057qib7 11452 7 lymphoma lymphoma NN cord-005453-4057qib7 11452 8 and and CC cord-005453-4057qib7 11452 9 5 5 CD cord-005453-4057qib7 11452 10 patients patient NNS cord-005453-4057qib7 11452 11 had have VBD cord-005453-4057qib7 11452 12 Hodgkin Hodgkin NNP cord-005453-4057qib7 11452 13 lymphoma lymphoma NN cord-005453-4057qib7 11452 14 . . . cord-005453-4057qib7 11453 1 The the DT cord-005453-4057qib7 11453 2 characteristics characteristic NNS cord-005453-4057qib7 11453 3 of of IN cord-005453-4057qib7 11453 4 the the DT cord-005453-4057qib7 11453 5 patients patient NNS cord-005453-4057qib7 11453 6 are be VBP cord-005453-4057qib7 11453 7 summarized summarize VBN cord-005453-4057qib7 11453 8 in in IN cord-005453-4057qib7 11453 9 Table Table NNP cord-005453-4057qib7 11453 10 _SP cord-005453-4057qib7 11453 11 1 1 CD cord-005453-4057qib7 11453 12 . . . cord-005453-4057qib7 11454 1 Patients patient NNS cord-005453-4057qib7 11454 2 ' ' POS cord-005453-4057qib7 11454 3 comorbidity comorbidity NN cord-005453-4057qib7 11454 4 indexes index NNS cord-005453-4057qib7 11454 5 were be VBD cord-005453-4057qib7 11454 6 calculated calculate VBN cord-005453-4057qib7 11454 7 with with IN cord-005453-4057qib7 11454 8 Augmented Augmented NNP cord-005453-4057qib7 11454 9 HCT HCT NNP cord-005453-4057qib7 11454 10 - - HYPH cord-005453-4057qib7 11454 11 CI CI NNP cord-005453-4057qib7 11454 12 which which WDT cord-005453-4057qib7 11454 13 includes include VBZ cord-005453-4057qib7 11454 14 patients patient NNS cord-005453-4057qib7 11454 15 ' ' POS cord-005453-4057qib7 11454 16 pretransplant pretransplant JJ cord-005453-4057qib7 11454 17 ferritin ferritin NN cord-005453-4057qib7 11454 18 , , , cord-005453-4057qib7 11454 19 albümin albümin NNP cord-005453-4057qib7 11454 20 and and CC cord-005453-4057qib7 11454 21 thrombocyte thrombocyte NNP cord-005453-4057qib7 11454 22 counts count VBZ cord-005453-4057qib7 11454 23 as as IN cord-005453-4057qib7 11454 24 a a DT cord-005453-4057qib7 11454 25 variable variable NN cord-005453-4057qib7 11454 26 . . . cord-005453-4057qib7 11455 1 No no DT cord-005453-4057qib7 11455 2 difference difference NN cord-005453-4057qib7 11455 3 could could MD cord-005453-4057qib7 11455 4 be be VB cord-005453-4057qib7 11455 5 found find VBN cord-005453-4057qib7 11455 6 between between IN cord-005453-4057qib7 11455 7 groups group NNS cord-005453-4057qib7 11455 8 regarding regard VBG cord-005453-4057qib7 11455 9 neutrophil neutrophil NN cord-005453-4057qib7 11455 10 and and CC cord-005453-4057qib7 11455 11 platelet platelet NN cord-005453-4057qib7 11455 12 engraftment engraftment NN cord-005453-4057qib7 11455 13 times time NNS cord-005453-4057qib7 11455 14 and and CC cord-005453-4057qib7 11455 15 comorbidity comorbidity NN cord-005453-4057qib7 11455 16 indexes index NNS cord-005453-4057qib7 11455 17 . . . cord-005453-4057qib7 11456 1 However however RB cord-005453-4057qib7 11456 2 , , , cord-005453-4057qib7 11456 3 acute acute JJ cord-005453-4057qib7 11456 4 graft graft NN cord-005453-4057qib7 11456 5 versus versus IN cord-005453-4057qib7 11456 6 rate rate NN cord-005453-4057qib7 11456 7 and and CC cord-005453-4057qib7 11456 8 documented document VBD cord-005453-4057qib7 11456 9 bacterial bacterial JJ cord-005453-4057qib7 11456 10 infection infection NN cord-005453-4057qib7 11456 11 rate rate NN cord-005453-4057qib7 11456 12 during during IN cord-005453-4057qib7 11456 13 the the DT cord-005453-4057qib7 11456 14 hospitalization hospitalization NN cord-005453-4057qib7 11456 15 period period NN cord-005453-4057qib7 11456 16 were be VBD cord-005453-4057qib7 11456 17 higher high JJR cord-005453-4057qib7 11456 18 in in IN cord-005453-4057qib7 11456 19 the the DT cord-005453-4057qib7 11456 20 50 50 CD cord-005453-4057qib7 11456 21 - - SYM cord-005453-4057qib7 11456 22 60 60 CD cord-005453-4057qib7 11456 23 years year NNS cord-005453-4057qib7 11456 24 age age NN cord-005453-4057qib7 11456 25 group group NN cord-005453-4057qib7 11456 26 ( ( -LRB- cord-005453-4057qib7 11456 27 p=0,01 p=0,01 NN cord-005453-4057qib7 11456 28 ) ) -RRB- cord-005453-4057qib7 11456 29 . . . cord-005453-4057qib7 11457 1 100 100 CD cord-005453-4057qib7 11457 2 day day NN cord-005453-4057qib7 11457 3 mortality mortality NN cord-005453-4057qib7 11457 4 rate rate NN cord-005453-4057qib7 11457 5 and and CC cord-005453-4057qib7 11457 6 non non JJ cord-005453-4057qib7 11457 7 - - JJ cord-005453-4057qib7 11457 8 relapse relapse JJ cord-005453-4057qib7 11457 9 mortality mortality NN cord-005453-4057qib7 11457 10 rate rate NN cord-005453-4057qib7 11457 11 were be VBD cord-005453-4057qib7 11457 12 not not RB cord-005453-4057qib7 11457 13 different different JJ cord-005453-4057qib7 11457 14 between between IN cord-005453-4057qib7 11457 15 groups group NNS cord-005453-4057qib7 11457 16 . . . cord-005453-4057qib7 11458 1 More more RBR cord-005453-4057qib7 11458 2 importantly importantly RB cord-005453-4057qib7 11458 3 , , , cord-005453-4057qib7 11458 4 Progression progression NN cord-005453-4057qib7 11458 5 free free JJ cord-005453-4057qib7 11458 6 survival(PFS survival(pfs RB cord-005453-4057qib7 11458 7 ) ) -RRB- cord-005453-4057qib7 11458 8 and and CC cord-005453-4057qib7 11458 9 overall overall RB cord-005453-4057qib7 11458 10 survival(OS survival(os JJ cord-005453-4057qib7 11458 11 ) ) -RRB- cord-005453-4057qib7 11459 1 of of IN cord-005453-4057qib7 11459 2 patients patient NNS cord-005453-4057qib7 11459 3 in in IN cord-005453-4057qib7 11459 4 the the DT cord-005453-4057qib7 11459 5 50 50 CD cord-005453-4057qib7 11459 6 - - SYM cord-005453-4057qib7 11459 7 60 60 CD cord-005453-4057qib7 11459 8 years year NNS cord-005453-4057qib7 11459 9 age age NN cord-005453-4057qib7 11459 10 group group NN cord-005453-4057qib7 11459 11 and and CC cord-005453-4057qib7 11459 12 over over IN cord-005453-4057qib7 11459 13 60 60 CD cord-005453-4057qib7 11459 14 years year NNS cord-005453-4057qib7 11459 15 of of IN cord-005453-4057qib7 11459 16 age age NN cord-005453-4057qib7 11459 17 group group NN cord-005453-4057qib7 11459 18 were be VBD cord-005453-4057qib7 11459 19 not not RB cord-005453-4057qib7 11459 20 different different JJ cord-005453-4057qib7 11459 21 ( ( -LRB- cord-005453-4057qib7 11459 22 p=0,45 p=0,45 NNP cord-005453-4057qib7 11459 23 ) ) -RRB- cord-005453-4057qib7 11460 1 ( ( -LRB- cord-005453-4057qib7 11460 2 Figure figure NN cord-005453-4057qib7 11460 3 1 1 CD cord-005453-4057qib7 11460 4 ) ) -RRB- cord-005453-4057qib7 11460 5 Conclusions conclusion NNS cord-005453-4057qib7 11460 6 : : : cord-005453-4057qib7 11461 1 In in IN cord-005453-4057qib7 11461 2 the the DT cord-005453-4057qib7 11461 3 present present JJ cord-005453-4057qib7 11461 4 study study NN cord-005453-4057qib7 11461 5 , , , cord-005453-4057qib7 11461 6 although although IN cord-005453-4057qib7 11461 7 the the DT cord-005453-4057qib7 11461 8 number number NN cord-005453-4057qib7 11461 9 of of IN cord-005453-4057qib7 11461 10 patients patient NNS cord-005453-4057qib7 11461 11 is be VBZ cord-005453-4057qib7 11461 12 low low JJ cord-005453-4057qib7 11461 13 , , , cord-005453-4057qib7 11461 14 we -PRON- PRP cord-005453-4057qib7 11461 15 showed show VBD cord-005453-4057qib7 11461 16 that that IN cord-005453-4057qib7 11461 17 lymphoma lymphoma NN cord-005453-4057qib7 11461 18 patients patient NNS cord-005453-4057qib7 11461 19 over over IN cord-005453-4057qib7 11461 20 60 60 CD cord-005453-4057qib7 11461 21 years year NNS cord-005453-4057qib7 11461 22 of of IN cord-005453-4057qib7 11461 23 age age NN cord-005453-4057qib7 11461 24 have have VBP cord-005453-4057qib7 11461 25 similar similar JJ cord-005453-4057qib7 11461 26 outcomes outcome NNS cord-005453-4057qib7 11461 27 and and CC cord-005453-4057qib7 11461 28 transplant transplant NN cord-005453-4057qib7 11461 29 related relate VBN cord-005453-4057qib7 11461 30 toxicity toxicity NN cord-005453-4057qib7 11461 31 as as IN cord-005453-4057qib7 11461 32 the the DT cord-005453-4057qib7 11461 33 patients patient NNS cord-005453-4057qib7 11461 34 between between IN cord-005453-4057qib7 11461 35 50 50 CD cord-005453-4057qib7 11461 36 to to TO cord-005453-4057qib7 11461 37 60 60 CD cord-005453-4057qib7 11461 38 years year NNS cord-005453-4057qib7 11461 39 of of IN cord-005453-4057qib7 11461 40 age age NN cord-005453-4057qib7 11461 41 . . . cord-005453-4057qib7 11462 1 PFS PFS NNP cord-005453-4057qib7 11462 2 and and CC cord-005453-4057qib7 11462 3 OS OS NNP cord-005453-4057qib7 11462 4 were be VBD cord-005453-4057qib7 11462 5 very very RB cord-005453-4057qib7 11462 6 close close JJ cord-005453-4057qib7 11462 7 in in IN cord-005453-4057qib7 11462 8 this this DT cord-005453-4057qib7 11462 9 study study NN cord-005453-4057qib7 11462 10 . . . cord-005453-4057qib7 11463 1 We -PRON- PRP cord-005453-4057qib7 11463 2 think think VBP cord-005453-4057qib7 11463 3 that that IN cord-005453-4057qib7 11463 4 this this DT cord-005453-4057qib7 11463 5 may may MD cord-005453-4057qib7 11463 6 be be VB cord-005453-4057qib7 11463 7 due due JJ cord-005453-4057qib7 11463 8 to to IN cord-005453-4057qib7 11463 9 low low JJ cord-005453-4057qib7 11463 10 relapse relapse NN cord-005453-4057qib7 11463 11 rate rate NN cord-005453-4057qib7 11463 12 in in IN cord-005453-4057qib7 11463 13 the the DT cord-005453-4057qib7 11463 14 patients patient NNS cord-005453-4057qib7 11463 15 and and CC cord-005453-4057qib7 11463 16 high high JJ cord-005453-4057qib7 11463 17 mortality mortality NN cord-005453-4057qib7 11463 18 rate rate NN cord-005453-4057qib7 11463 19 in in IN cord-005453-4057qib7 11463 20 relapsing relapse VBG cord-005453-4057qib7 11463 21 patients patient NNS cord-005453-4057qib7 11463 22 . . . cord-005453-4057qib7 11464 1 In in IN cord-005453-4057qib7 11464 2 conclusion conclusion NN cord-005453-4057qib7 11464 3 , , , cord-005453-4057qib7 11464 4 allogeneic allogeneic IN cord-005453-4057qib7 11464 5 stem stem NN cord-005453-4057qib7 11464 6 cell cell NN cord-005453-4057qib7 11464 7 transplantation transplantation NN cord-005453-4057qib7 11464 8 which which WDT cord-005453-4057qib7 11464 9 has have VBZ cord-005453-4057qib7 11464 10 a a DT cord-005453-4057qib7 11464 11 curative curative JJ cord-005453-4057qib7 11464 12 potential potential NN cord-005453-4057qib7 11464 13 may may MD cord-005453-4057qib7 11464 14 be be VB cord-005453-4057qib7 11464 15 employed employ VBN cord-005453-4057qib7 11464 16 in in IN cord-005453-4057qib7 11464 17 transplant transplant NN cord-005453-4057qib7 11464 18 eligible eligible JJ cord-005453-4057qib7 11464 19 elderly elderly JJ cord-005453-4057qib7 11464 20 lymphoma lymphoma NN cord-005453-4057qib7 11464 21 patients patient NNS cord-005453-4057qib7 11464 22 Disclosure Disclosure NNP cord-005453-4057qib7 11464 23 : : : cord-005453-4057qib7 11464 24 Nothing nothing NN cord-005453-4057qib7 11464 25 to to TO cord-005453-4057qib7 11464 26 declare declare VB cord-005453-4057qib7 11464 27 Background background NN cord-005453-4057qib7 11464 28 : : : cord-005453-4057qib7 11464 29 Follicular follicular JJ cord-005453-4057qib7 11464 30 Lymphoma Lymphoma NNP cord-005453-4057qib7 11464 31 ( ( -LRB- cord-005453-4057qib7 11464 32 FL FL NNP cord-005453-4057qib7 11464 33 ) ) -RRB- cord-005453-4057qib7 11464 34 histologic histologic JJ cord-005453-4057qib7 11464 35 transformation transformation NN cord-005453-4057qib7 11464 36 consist consist VBP cord-005453-4057qib7 11464 37 on on IN cord-005453-4057qib7 11464 38 the the DT cord-005453-4057qib7 11464 39 development development NN cord-005453-4057qib7 11464 40 of of IN cord-005453-4057qib7 11464 41 an an DT cord-005453-4057qib7 11464 42 aggressive aggressive JJ cord-005453-4057qib7 11464 43 lymphoma lymphoma NN cord-005453-4057qib7 11464 44 , , , cord-005453-4057qib7 11464 45 usually usually RB cord-005453-4057qib7 11464 46 a a DT cord-005453-4057qib7 11464 47 diffuse diffuse JJ cord-005453-4057qib7 11464 48 large large JJ cord-005453-4057qib7 11464 49 B b NN cord-005453-4057qib7 11464 50 cell cell NN cord-005453-4057qib7 11464 51 lymphoma lymphoma NN cord-005453-4057qib7 11464 52 ( ( -LRB- cord-005453-4057qib7 11464 53 DLBCL DLBCL NNP cord-005453-4057qib7 11464 54 ) ) -RRB- cord-005453-4057qib7 11464 55 . . . cord-005453-4057qib7 11465 1 Histological histological JJ cord-005453-4057qib7 11465 2 transformation transformation NN cord-005453-4057qib7 11465 3 has have VBZ cord-005453-4057qib7 11465 4 been be VBN cord-005453-4057qib7 11465 5 considered consider VBN cord-005453-4057qib7 11465 6 to to TO cord-005453-4057qib7 11465 7 have have VB cord-005453-4057qib7 11465 8 poor poor JJ cord-005453-4057qib7 11465 9 prognosis prognosis NN cord-005453-4057qib7 11465 10 . . . cord-005453-4057qib7 11466 1 In in IN cord-005453-4057qib7 11466 2 pre pre JJ cord-005453-4057qib7 11466 3 - - JJ cord-005453-4057qib7 11466 4 rituximab rituximab JJ cord-005453-4057qib7 11466 5 era era NN cord-005453-4057qib7 11466 6 median median NN cord-005453-4057qib7 11466 7 OS os NN cord-005453-4057qib7 11466 8 ranged range VBD cord-005453-4057qib7 11466 9 between between IN cord-005453-4057qib7 11466 10 1 1 CD cord-005453-4057qib7 11466 11 and and CC cord-005453-4057qib7 11466 12 2 2 CD cord-005453-4057qib7 11466 13 years year NNS cord-005453-4057qib7 11466 14 , , , cord-005453-4057qib7 11466 15 however however RB cord-005453-4057qib7 11466 16 , , , cord-005453-4057qib7 11466 17 in in IN cord-005453-4057qib7 11466 18 recent recent JJ cord-005453-4057qib7 11466 19 series series NN cord-005453-4057qib7 11466 20 of of IN cord-005453-4057qib7 11466 21 patients patient NNS cord-005453-4057qib7 11466 22 treated treat VBN cord-005453-4057qib7 11466 23 with with IN cord-005453-4057qib7 11466 24 chemotherapy chemotherapy NN cord-005453-4057qib7 11466 25 plus plus CC cord-005453-4057qib7 11466 26 rituximab rituximab NN cord-005453-4057qib7 11466 27 , , , cord-005453-4057qib7 11466 28 the the DT cord-005453-4057qib7 11466 29 outcome outcome NN cord-005453-4057qib7 11466 30 of of IN cord-005453-4057qib7 11466 31 transformed transform VBN cord-005453-4057qib7 11466 32 FL FL NNP cord-005453-4057qib7 11466 33 has have VBZ cord-005453-4057qib7 11466 34 improved improve VBN cord-005453-4057qib7 11466 35 , , , cord-005453-4057qib7 11466 36 especially especially RB cord-005453-4057qib7 11466 37 in in IN cord-005453-4057qib7 11466 38 those those DT cord-005453-4057qib7 11466 39 that that WDT cord-005453-4057qib7 11466 40 receive receive VBP cord-005453-4057qib7 11466 41 Autologous autologous JJ cord-005453-4057qib7 11466 42 stem stem NN cord-005453-4057qib7 11466 43 cell cell NN cord-005453-4057qib7 11466 44 transplantation transplantation NN cord-005453-4057qib7 11466 45 ( ( -LRB- cord-005453-4057qib7 11466 46 ASCT ASCT NNP cord-005453-4057qib7 11466 47 ) ) -RRB- cord-005453-4057qib7 11466 48 , , , cord-005453-4057qib7 11466 49 who who WP cord-005453-4057qib7 11466 50 reach reach VBP cord-005453-4057qib7 11466 51 5-year 5-year CD cord-005453-4057qib7 11466 52 OS os NN cord-005453-4057qib7 11466 53 up up IN cord-005453-4057qib7 11466 54 to to TO cord-005453-4057qib7 11466 55 75 75 CD cord-005453-4057qib7 11466 56 % % NN cord-005453-4057qib7 11466 57 in in IN cord-005453-4057qib7 11466 58 some some DT cord-005453-4057qib7 11466 59 series series NN cord-005453-4057qib7 11466 60 . . . cord-005453-4057qib7 11467 1 Methods method NNS cord-005453-4057qib7 11467 2 : : : cord-005453-4057qib7 11467 3 We -PRON- PRP cord-005453-4057qib7 11467 4 have have VBP cord-005453-4057qib7 11467 5 retrospectively retrospectively RB cord-005453-4057qib7 11467 6 studied study VBN cord-005453-4057qib7 11467 7 19 19 CD cord-005453-4057qib7 11467 8 consecutive consecutive JJ cord-005453-4057qib7 11467 9 patients patient NNS cord-005453-4057qib7 11467 10 undergoing undergo VBG cord-005453-4057qib7 11467 11 ASCT ASCT NNP cord-005453-4057qib7 11467 12 for for IN cord-005453-4057qib7 11467 13 transformed transform VBN cord-005453-4057qib7 11467 14 FL FL NNP cord-005453-4057qib7 11467 15 between between IN cord-005453-4057qib7 11467 16 2006 2006 CD cord-005453-4057qib7 11467 17 and and CC cord-005453-4057qib7 11467 18 2015 2015 CD cord-005453-4057qib7 11467 19 in in IN cord-005453-4057qib7 11467 20 a a DT cord-005453-4057qib7 11467 21 tertiary tertiary JJ cord-005453-4057qib7 11467 22 center center NN cord-005453-4057qib7 11467 23 in in IN cord-005453-4057qib7 11467 24 the the DT cord-005453-4057qib7 11467 25 Basque Basque NNP cord-005453-4057qib7 11467 26 Country Country NNP cord-005453-4057qib7 11467 27 , , , cord-005453-4057qib7 11467 28 Spain Spain NNP cord-005453-4057qib7 11467 29 . . . cord-005453-4057qib7 11468 1 Patients patient NNS cord-005453-4057qib7 11468 2 were be VBD cord-005453-4057qib7 11468 3 considered consider VBN cord-005453-4057qib7 11468 4 to to TO cord-005453-4057qib7 11468 5 have have VB cord-005453-4057qib7 11468 6 a a DT cord-005453-4057qib7 11468 7 transformed transform VBN cord-005453-4057qib7 11468 8 FL FL NNP cord-005453-4057qib7 11468 9 if if IN cord-005453-4057qib7 11468 10 they -PRON- PRP cord-005453-4057qib7 11468 11 were be VBD cord-005453-4057qib7 11468 12 diagnosed diagnose VBN cord-005453-4057qib7 11468 13 of of IN cord-005453-4057qib7 11468 14 a a DT cord-005453-4057qib7 11468 15 DLBCL dlbcl NN cord-005453-4057qib7 11468 16 and and CC cord-005453-4057qib7 11468 17 they -PRON- PRP cord-005453-4057qib7 11468 18 have have VBP cord-005453-4057qib7 11468 19 previous previous JJ cord-005453-4057qib7 11468 20 history history NN cord-005453-4057qib7 11468 21 of of IN cord-005453-4057qib7 11468 22 FL FL NNP cord-005453-4057qib7 11468 23 or or CC cord-005453-4057qib7 11468 24 histological histological JJ cord-005453-4057qib7 11468 25 evidence evidence NN cord-005453-4057qib7 11468 26 of of IN cord-005453-4057qib7 11468 27 a a DT cord-005453-4057qib7 11468 28 FL FL NNP cord-005453-4057qib7 11468 29 in in IN cord-005453-4057qib7 11468 30 another another DT cord-005453-4057qib7 11468 31 location location NN cord-005453-4057qib7 11468 32 . . . cord-005453-4057qib7 11469 1 These these DT cord-005453-4057qib7 11469 2 patients patient NNS cord-005453-4057qib7 11469 3 were be VBD cord-005453-4057qib7 11469 4 compared compare VBN cord-005453-4057qib7 11469 5 to to IN cord-005453-4057qib7 11469 6 a a DT cord-005453-4057qib7 11469 7 retrospective retrospective JJ cord-005453-4057qib7 11469 8 cohort cohort NN cord-005453-4057qib7 11469 9 of of IN cord-005453-4057qib7 11469 10 38 38 CD cord-005453-4057qib7 11469 11 DLBCL DLBCL NNP cord-005453-4057qib7 11469 12 patients patient NNS cord-005453-4057qib7 11469 13 with with IN cord-005453-4057qib7 11469 14 high high JJ cord-005453-4057qib7 11469 15 IPI IPI NNP cord-005453-4057qib7 11469 16 or or CC cord-005453-4057qib7 11469 17 stage stage NN cord-005453-4057qib7 11469 18 that that WDT cord-005453-4057qib7 11469 19 received receive VBD cord-005453-4057qib7 11469 20 ASCT ASCT NNP cord-005453-4057qib7 11469 21 in in IN cord-005453-4057qib7 11469 22 first first JJ cord-005453-4057qib7 11469 23 remission remission NN cord-005453-4057qib7 11469 24 according accord VBG cord-005453-4057qib7 11469 25 to to IN cord-005453-4057qib7 11469 26 our -PRON- PRP$ cord-005453-4057qib7 11469 27 institution institution NN cord-005453-4057qib7 11469 28 strategy strategy NN cord-005453-4057qib7 11469 29 . . . cord-005453-4057qib7 11470 1 PFS PFS NNP cord-005453-4057qib7 11470 2 and and CC cord-005453-4057qib7 11470 3 OS OS NNP cord-005453-4057qib7 11470 4 were be VBD cord-005453-4057qib7 11470 5 calculated calculate VBN cord-005453-4057qib7 11470 6 from from IN cord-005453-4057qib7 11470 7 the the DT cord-005453-4057qib7 11470 8 time time NN cord-005453-4057qib7 11470 9 of of IN cord-005453-4057qib7 11470 10 the the DT cord-005453-4057qib7 11470 11 ASCT ASCT NNP cord-005453-4057qib7 11470 12 . . . cord-005453-4057qib7 11471 1 In in IN cord-005453-4057qib7 11471 2 the the DT cord-005453-4057qib7 11471 3 case case NN cord-005453-4057qib7 11471 4 of of IN cord-005453-4057qib7 11471 5 transformed transform VBN cord-005453-4057qib7 11471 6 FL FL NNP cord-005453-4057qib7 11471 7 , , , cord-005453-4057qib7 11471 8 both both CC cord-005453-4057qib7 11471 9 relapses relapse NNS cord-005453-4057qib7 11471 10 of of IN cord-005453-4057qib7 11471 11 the the DT cord-005453-4057qib7 11471 12 aggressive aggressive JJ cord-005453-4057qib7 11471 13 or or CC cord-005453-4057qib7 11471 14 indolent indolent JJ cord-005453-4057qib7 11471 15 lymphoma lymphoma NN cord-005453-4057qib7 11471 16 were be VBD cord-005453-4057qib7 11471 17 considered consider VBN cord-005453-4057qib7 11471 18 . . . cord-005453-4057qib7 11472 1 Survival survival NN cord-005453-4057qib7 11472 2 analysis analysis NN cord-005453-4057qib7 11472 3 was be VBD cord-005453-4057qib7 11472 4 performed perform VBN cord-005453-4057qib7 11472 5 with with IN cord-005453-4057qib7 11472 6 Kaplan Kaplan NNP cord-005453-4057qib7 11472 7 - - HYPH cord-005453-4057qib7 11472 8 Meyer Meyer NNP cord-005453-4057qib7 11472 9 estimator estimator NN cord-005453-4057qib7 11472 10 Results result VBZ cord-005453-4057qib7 11472 11 : : : cord-005453-4057qib7 11472 12 A a DT cord-005453-4057qib7 11472 13 total total NN cord-005453-4057qib7 11472 14 of of IN cord-005453-4057qib7 11472 15 19 19 CD cord-005453-4057qib7 11472 16 transformed transform VBN cord-005453-4057qib7 11472 17 FL FL NNP cord-005453-4057qib7 11472 18 and and CC cord-005453-4057qib7 11472 19 38 38 CD cord-005453-4057qib7 11472 20 DLBCL DLBCL NNP cord-005453-4057qib7 11472 21 patients patient NNS cord-005453-4057qib7 11472 22 were be VBD cord-005453-4057qib7 11472 23 studied study VBN cord-005453-4057qib7 11472 24 , , , cord-005453-4057qib7 11472 25 with with IN cord-005453-4057qib7 11472 26 a a DT cord-005453-4057qib7 11472 27 median median NN cord-005453-4057qib7 11472 28 follow follow NN cord-005453-4057qib7 11472 29 up up IN cord-005453-4057qib7 11472 30 of of IN cord-005453-4057qib7 11472 31 41.4 41.4 CD cord-005453-4057qib7 11472 32 and and CC cord-005453-4057qib7 11472 33 51.7 51.7 CD cord-005453-4057qib7 11472 34 months month NNS cord-005453-4057qib7 11472 35 respectively respectively RB cord-005453-4057qib7 11472 36 . . . cord-005453-4057qib7 11473 1 Patient patient JJ cord-005453-4057qib7 11473 2 characteristics characteristic NNS cord-005453-4057qib7 11473 3 are be VBP cord-005453-4057qib7 11473 4 described describe VBN cord-005453-4057qib7 11473 5 in in IN cord-005453-4057qib7 11473 6 table table NN cord-005453-4057qib7 11473 7 1 1 CD cord-005453-4057qib7 11473 8 . . . cord-005453-4057qib7 11474 1 3-year 3-year JJ cord-005453-4057qib7 11474 2 PFS PFS NNP cord-005453-4057qib7 11474 3 was be VBD cord-005453-4057qib7 11474 4 68 68 CD cord-005453-4057qib7 11474 5 % % NN cord-005453-4057qib7 11474 6 in in IN cord-005453-4057qib7 11474 7 transformed transform VBN cord-005453-4057qib7 11474 8 FL FL NNP cord-005453-4057qib7 11474 9 and and CC cord-005453-4057qib7 11474 10 81 81 CD cord-005453-4057qib7 11474 11 % % NN cord-005453-4057qib7 11474 12 in in IN cord-005453-4057qib7 11474 13 DLBCL DLBCL NNP cord-005453-4057qib7 11474 14 , , , cord-005453-4057qib7 11474 15 and and CC cord-005453-4057qib7 11474 16 3-year 3-year JJ cord-005453-4057qib7 11474 17 OS os NN cord-005453-4057qib7 11474 18 was be VBD cord-005453-4057qib7 11474 19 81 81 CD cord-005453-4057qib7 11474 20 % % NN cord-005453-4057qib7 11474 21 and and CC cord-005453-4057qib7 11474 22 84 84 CD cord-005453-4057qib7 11474 23 % % NN cord-005453-4057qib7 11474 24 , , , cord-005453-4057qib7 11474 25 respectively respectively RB cord-005453-4057qib7 11474 26 ( ( -LRB- cord-005453-4057qib7 11474 27 picture picture NN cord-005453-4057qib7 11474 28 1 1 CD cord-005453-4057qib7 11474 29 ) ) -RRB- cord-005453-4057qib7 11474 30 . . . cord-005453-4057qib7 11475 1 There there EX cord-005453-4057qib7 11475 2 were be VBD cord-005453-4057qib7 11475 3 no no DT cord-005453-4057qib7 11475 4 significant significant JJ cord-005453-4057qib7 11475 5 differences difference NNS cord-005453-4057qib7 11475 6 in in IN cord-005453-4057qib7 11475 7 PFS PFS NNP cord-005453-4057qib7 11475 8 or or CC cord-005453-4057qib7 11475 9 OS OS NNP cord-005453-4057qib7 11475 10 between between IN cord-005453-4057qib7 11475 11 this this DT cord-005453-4057qib7 11475 12 two two CD cord-005453-4057qib7 11475 13 groups group NNS cord-005453-4057qib7 11475 14 ( ( -LRB- cord-005453-4057qib7 11475 15 p p NN cord-005453-4057qib7 11475 16 = = SYM cord-005453-4057qib7 11475 17 0.44 0.44 CD cord-005453-4057qib7 11475 18 ) ) -RRB- cord-005453-4057qib7 11475 19 . . . cord-005453-4057qib7 11476 1 In in IN cord-005453-4057qib7 11476 2 both both DT cord-005453-4057qib7 11476 3 groups group NNS cord-005453-4057qib7 11476 4 all all DT cord-005453-4057qib7 11476 5 relapses relapse NNS cord-005453-4057qib7 11476 6 occurred occur VBD cord-005453-4057qib7 11476 7 in in IN cord-005453-4057qib7 11476 8 the the DT cord-005453-4057qib7 11476 9 first first JJ cord-005453-4057qib7 11476 10 three three CD cord-005453-4057qib7 11476 11 years year NNS cord-005453-4057qib7 11476 12 after after IN cord-005453-4057qib7 11476 13 ASCT ASCT NNP cord-005453-4057qib7 11476 14 . . . cord-005453-4057qib7 11477 1 Among among IN cord-005453-4057qib7 11477 2 the the DT cord-005453-4057qib7 11477 3 patients patient NNS cord-005453-4057qib7 11477 4 with with IN cord-005453-4057qib7 11477 5 transformed transform VBN cord-005453-4057qib7 11477 6 FL FL NNP cord-005453-4057qib7 11477 7 6 6 CD cord-005453-4057qib7 11477 8 relapses relapse NNS cord-005453-4057qib7 11477 9 were be VBD cord-005453-4057qib7 11477 10 observed observe VBN cord-005453-4057qib7 11477 11 . . . cord-005453-4057qib7 11478 1 Five five CD cord-005453-4057qib7 11478 2 of of IN cord-005453-4057qib7 11478 3 them -PRON- PRP cord-005453-4057qib7 11478 4 ( ( -LRB- cord-005453-4057qib7 11478 5 83 83 CD cord-005453-4057qib7 11478 6 % % NN cord-005453-4057qib7 11478 7 ) ) -RRB- cord-005453-4057qib7 11478 8 were be VBD cord-005453-4057qib7 11478 9 aggressive aggressive JJ cord-005453-4057qib7 11478 10 relapses relapse NNS cord-005453-4057qib7 11478 11 , , , cord-005453-4057qib7 11478 12 while while IN cord-005453-4057qib7 11478 13 only only RB cord-005453-4057qib7 11478 14 one one CD cord-005453-4057qib7 11478 15 patient patient NN cord-005453-4057qib7 11478 16 presented present VBD cord-005453-4057qib7 11478 17 relapse relapse NN cord-005453-4057qib7 11478 18 as as IN cord-005453-4057qib7 11478 19 an an DT cord-005453-4057qib7 11478 20 indolent indolent JJ cord-005453-4057qib7 11478 21 lymphoma lymphoma NN cord-005453-4057qib7 11478 22 ( ( -LRB- cord-005453-4057qib7 11478 23 FL FL NNP cord-005453-4057qib7 11478 24 histological histological JJ cord-005453-4057qib7 11478 25 grade grade NN cord-005453-4057qib7 11478 26 3A 3a NN cord-005453-4057qib7 11478 27 with with IN cord-005453-4057qib7 11478 28 an an DT cord-005453-4057qib7 11478 29 aggressive aggressive JJ cord-005453-4057qib7 11478 30 clinical clinical JJ cord-005453-4057qib7 11478 31 course course NN cord-005453-4057qib7 11478 32 ) ) -RRB- cord-005453-4057qib7 11478 33 . . . cord-005453-4057qib7 11479 1 [ [ -LRB- cord-005453-4057qib7 11479 2 [ [ -LRB- cord-005453-4057qib7 11479 3 P507 P507 NNP cord-005453-4057qib7 11479 4 Image image NN cord-005453-4057qib7 11479 5 ] ] -RRB- cord-005453-4057qib7 11479 6 1 1 CD cord-005453-4057qib7 11479 7 . . . cord-005453-4057qib7 11480 1 Image image NN cord-005453-4057qib7 11480 2 1 1 CD cord-005453-4057qib7 11480 3 : : : cord-005453-4057qib7 11480 4 Transformed transform VBN cord-005453-4057qib7 11480 5 FL FL NNP cord-005453-4057qib7 11480 6 and and CC cord-005453-4057qib7 11480 7 DLBCL DLBCL NNP cord-005453-4057qib7 11480 8 PFS PFS NNP cord-005453-4057qib7 11480 9 after after IN cord-005453-4057qib7 11480 10 ASCT ASCT NNP cord-005453-4057qib7 11480 11 ] ] -RRB- cord-005453-4057qib7 11481 1 Conclusions conclusion NNS cord-005453-4057qib7 11481 2 : : : cord-005453-4057qib7 11481 3 In in IN cord-005453-4057qib7 11481 4 our -PRON- PRP$ cord-005453-4057qib7 11481 5 experience experience NN cord-005453-4057qib7 11481 6 , , , cord-005453-4057qib7 11481 7 ASCT ASCT NNP cord-005453-4057qib7 11481 8 in in IN cord-005453-4057qib7 11481 9 transformed transform VBN cord-005453-4057qib7 11481 10 FL FL NNP cord-005453-4057qib7 11481 11 offers offer VBZ cord-005453-4057qib7 11481 12 good good JJ cord-005453-4057qib7 11481 13 results result NNS cord-005453-4057qib7 11481 14 , , , cord-005453-4057qib7 11481 15 similar similar JJ cord-005453-4057qib7 11481 16 to to IN cord-005453-4057qib7 11481 17 those those DT cord-005453-4057qib7 11481 18 in in IN cord-005453-4057qib7 11481 19 DLBCL DLBCL NNP cord-005453-4057qib7 11481 20 . . . cord-005453-4057qib7 11482 1 FL FL NNP cord-005453-4057qib7 11482 2 presents present VBZ cord-005453-4057qib7 11482 3 a a DT cord-005453-4057qib7 11482 4 natural natural JJ cord-005453-4057qib7 11482 5 course course NN cord-005453-4057qib7 11482 6 akin akin JJ cord-005453-4057qib7 11482 7 to to IN cord-005453-4057qib7 11482 8 that that DT cord-005453-4057qib7 11482 9 of of IN cord-005453-4057qib7 11482 10 DLBCL DLBCL NNP cord-005453-4057qib7 11482 11 , , , cord-005453-4057qib7 11482 12 with with IN cord-005453-4057qib7 11482 13 relapses relapse NNS cord-005453-4057qib7 11482 14 occurring occur VBG cord-005453-4057qib7 11482 15 early early RB cord-005453-4057qib7 11482 16 and and CC cord-005453-4057qib7 11482 17 survival survival NN cord-005453-4057qib7 11482 18 reaching reach VBG cord-005453-4057qib7 11482 19 a a DT cord-005453-4057qib7 11482 20 plateau plateau NN cord-005453-4057qib7 11482 21 . . . cord-005453-4057qib7 11483 1 This this DT cord-005453-4057qib7 11483 2 data data NN cord-005453-4057qib7 11483 3 suggests suggest VBZ cord-005453-4057qib7 11483 4 that that IN cord-005453-4057qib7 11483 5 some some DT cord-005453-4057qib7 11483 6 patients patient NNS cord-005453-4057qib7 11483 7 with with IN cord-005453-4057qib7 11483 8 transformed transform VBN cord-005453-4057qib7 11483 9 FL FL NNP cord-005453-4057qib7 11483 10 can can MD cord-005453-4057qib7 11483 11 be be VB cord-005453-4057qib7 11483 12 cured cure VBN cord-005453-4057qib7 11483 13 after after IN cord-005453-4057qib7 11483 14 ASCT ASCT NNP cord-005453-4057qib7 11483 15 . . . cord-005453-4057qib7 11484 1 Disclosure disclosure NN cord-005453-4057qib7 11484 2 : : : cord-005453-4057qib7 11484 3 Nothing nothing NN cord-005453-4057qib7 11484 4 to to TO cord-005453-4057qib7 11484 5 declare declare VB cord-005453-4057qib7 11484 6 . . . cord-005453-4057qib7 11485 1 Safety safety NN cord-005453-4057qib7 11485 2 and and CC cord-005453-4057qib7 11485 3 efficacy efficacy NN cord-005453-4057qib7 11485 4 of of IN cord-005453-4057qib7 11485 5 intensive intensive JJ cord-005453-4057qib7 11485 6 preconditioning preconditioning NN cord-005453-4057qib7 11485 7 regimen regimen NN cord-005453-4057qib7 11485 8 containing contain VBG cord-005453-4057qib7 11485 9 cladribine cladribine NN cord-005453-4057qib7 11485 10 in in IN cord-005453-4057qib7 11485 11 autologous autologous JJ cord-005453-4057qib7 11485 12 peripheral peripheral JJ cord-005453-4057qib7 11485 13 blood blood NN cord-005453-4057qib7 11485 14 stem stem NN cord-005453-4057qib7 11485 15 cell cell NN cord-005453-4057qib7 11485 16 transplantation transplantation NN cord-005453-4057qib7 11485 17 of of IN cord-005453-4057qib7 11485 18 refractory refractory JJ cord-005453-4057qib7 11485 19 and and CC cord-005453-4057qib7 11485 20 relapsed relapse VBD cord-005453-4057qib7 11485 21 young young JJ cord-005453-4057qib7 11485 22 highly highly RB cord-005453-4057qib7 11485 23 invasive invasive JJ cord-005453-4057qib7 11485 24 lymphoma lymphoma NN cord-005453-4057qib7 11485 25 Background background NN cord-005453-4057qib7 11485 26 : : : cord-005453-4057qib7 11485 27 Autologous autologous JJ cord-005453-4057qib7 11485 28 peripheral peripheral JJ cord-005453-4057qib7 11485 29 blood blood NN cord-005453-4057qib7 11485 30 stem stem NN cord-005453-4057qib7 11485 31 cell cell NN cord-005453-4057qib7 11485 32 transplantation transplantation NN cord-005453-4057qib7 11485 33 ( ( -LRB- cord-005453-4057qib7 11485 34 APBSCT APBSCT NNP cord-005453-4057qib7 11485 35 ) ) -RRB- cord-005453-4057qib7 11485 36 is be VBZ cord-005453-4057qib7 11485 37 one one CD cord-005453-4057qib7 11485 38 of of IN cord-005453-4057qib7 11485 39 the the DT cord-005453-4057qib7 11485 40 main main JJ cord-005453-4057qib7 11485 41 treatments treatment NNS cord-005453-4057qib7 11485 42 for for IN cord-005453-4057qib7 11485 43 patients patient NNS cord-005453-4057qib7 11485 44 with with IN cord-005453-4057qib7 11485 45 non non JJ cord-005453-4057qib7 11485 46 - - JJ cord-005453-4057qib7 11485 47 Hodgkin Hodgkin NNP cord-005453-4057qib7 11485 48 's 's POS cord-005453-4057qib7 11485 49 lymphoma lymphoma NN cord-005453-4057qib7 11485 50 ( ( -LRB- cord-005453-4057qib7 11485 51 NHL NHL NNP cord-005453-4057qib7 11485 52 ) ) -RRB- cord-005453-4057qib7 11485 53 . . . cord-005453-4057qib7 11486 1 Effective effective JJ cord-005453-4057qib7 11486 2 and and CC cord-005453-4057qib7 11486 3 safe safe JJ cord-005453-4057qib7 11486 4 conditioning conditioning NN cord-005453-4057qib7 11486 5 regimens regimen NNS cord-005453-4057qib7 11486 6 can can MD cord-005453-4057qib7 11486 7 improve improve VB cord-005453-4057qib7 11486 8 the the DT cord-005453-4057qib7 11486 9 cure cure NN cord-005453-4057qib7 11486 10 rate rate NN cord-005453-4057qib7 11486 11 of of IN cord-005453-4057qib7 11486 12 NHL NHL NNP cord-005453-4057qib7 11486 13 . . . cord-005453-4057qib7 11487 1 BEAM beam NN cord-005453-4057qib7 11487 2 is be VBZ cord-005453-4057qib7 11487 3 the the DT cord-005453-4057qib7 11487 4 most most RBS cord-005453-4057qib7 11487 5 common common JJ cord-005453-4057qib7 11487 6 pretreatment pretreatment NN cord-005453-4057qib7 11487 7 scheme scheme NN cord-005453-4057qib7 11487 8 , , , cord-005453-4057qib7 11487 9 but but CC cord-005453-4057qib7 11487 10 for for IN cord-005453-4057qib7 11487 11 refractory refractory JJ cord-005453-4057qib7 11487 12 and and CC cord-005453-4057qib7 11487 13 relapsed relapse VBD cord-005453-4057qib7 11487 14 young young JJ cord-005453-4057qib7 11487 15 highly highly RB cord-005453-4057qib7 11487 16 invasive invasive JJ cord-005453-4057qib7 11487 17 lymphoma lymphoma NN cord-005453-4057qib7 11487 18 , , , cord-005453-4057qib7 11487 19 especially especially RB cord-005453-4057qib7 11487 20 for for IN cord-005453-4057qib7 11487 21 dual dual JJ cord-005453-4057qib7 11487 22 - - HYPH cord-005453-4057qib7 11487 23 expression expression NN cord-005453-4057qib7 11487 24 DLBCL dlbcl NN cord-005453-4057qib7 11487 25 , , , cord-005453-4057qib7 11487 26 pretreatment pretreatment NN cord-005453-4057qib7 11487 27 needs need VBZ cord-005453-4057qib7 11487 28 to to TO cord-005453-4057qib7 11487 29 be be VB cord-005453-4057qib7 11487 30 strengthened strengthen VBN cord-005453-4057qib7 11487 31 . . . cord-005453-4057qib7 11488 1 Studies study NNS cord-005453-4057qib7 11488 2 have have VBP cord-005453-4057qib7 11488 3 shown show VBN cord-005453-4057qib7 11488 4 that that IN cord-005453-4057qib7 11488 5 the the DT cord-005453-4057qib7 11488 6 Cladribine Cladribine NNP cord-005453-4057qib7 11488 7 ( ( -LRB- cord-005453-4057qib7 11488 8 Clad)+Gemcitabine clad)+gemcitabine UH cord-005453-4057qib7 11488 9 ( ( -LRB- cord-005453-4057qib7 11488 10 Gem)+Busulfan Gem)+Busulfan NNP cord-005453-4057qib7 11488 11 ( ( -LRB- cord-005453-4057qib7 11488 12 Bu Bu NNP cord-005453-4057qib7 11488 13 ) ) -RRB- cord-005453-4057qib7 11488 14 combination combination NN cord-005453-4057qib7 11488 15 provides provide VBZ cord-005453-4057qib7 11488 16 synergistic synergistic JJ cord-005453-4057qib7 11488 17 cytotoxicity cytotoxicity NN cord-005453-4057qib7 11488 18 in in IN cord-005453-4057qib7 11488 19 lymphoma lymphoma NN cord-005453-4057qib7 11488 20 cell cell NN cord-005453-4057qib7 11488 21 lines line NNS cord-005453-4057qib7 11488 22 . . . cord-005453-4057qib7 11489 1 We -PRON- PRP cord-005453-4057qib7 11489 2 evaluated evaluate VBD cord-005453-4057qib7 11489 3 the the DT cord-005453-4057qib7 11489 4 the the DT cord-005453-4057qib7 11489 5 safety safety NN cord-005453-4057qib7 11489 6 and and CC cord-005453-4057qib7 11489 7 short short JJ cord-005453-4057qib7 11489 8 - - HYPH cord-005453-4057qib7 11489 9 term term NN cord-005453-4057qib7 11489 10 efficacy efficacy NN cord-005453-4057qib7 11489 11 of of IN cord-005453-4057qib7 11489 12 intensive intensive JJ cord-005453-4057qib7 11489 13 preconditioning preconditioning NN cord-005453-4057qib7 11489 14 regimen regimen NN cord-005453-4057qib7 11489 15 containing contain VBG cord-005453-4057qib7 11489 16 cladribine cladribine NNP cord-005453-4057qib7 11489 17 ( ( -LRB- cord-005453-4057qib7 11489 18 Clad+GEM+BU Clad+GEM+BU NNP cord-005453-4057qib7 11489 19 ) ) -RRB- cord-005453-4057qib7 11489 20 for for IN cord-005453-4057qib7 11489 21 refractory refractory JJ cord-005453-4057qib7 11489 22 and and CC cord-005453-4057qib7 11489 23 relapsed relapse VBD cord-005453-4057qib7 11489 24 young young JJ cord-005453-4057qib7 11489 25 highly highly RB cord-005453-4057qib7 11489 26 invasive invasive JJ cord-005453-4057qib7 11489 27 lymphoma lymphoma NN cord-005453-4057qib7 11489 28 undergoing undergo VBG cord-005453-4057qib7 11489 29 APBSCT APBSCT NNP cord-005453-4057qib7 11489 30 . . . cord-005453-4057qib7 11490 1 Methods method NNS cord-005453-4057qib7 11490 2 : : : cord-005453-4057qib7 11491 1 Ten ten CD cord-005453-4057qib7 11491 2 patients patient NNS cord-005453-4057qib7 11491 3 with with IN cord-005453-4057qib7 11491 4 NHL NHL NNP cord-005453-4057qib7 11491 5 received receive VBD cord-005453-4057qib7 11491 6 APBSCT APBSCT NNP cord-005453-4057qib7 11491 7 . . . cord-005453-4057qib7 11492 1 CA)CTX+ CA)CTX+ NNP cord-005453-4057qib7 11492 2 Ara Ara NNP cord-005453-4057qib7 11492 3 - - HYPH cord-005453-4057qib7 11492 4 C C NNP cord-005453-4057qib7 11492 5 ) ) -RRB- cord-005453-4057qib7 11492 6 therapy therapy NN cord-005453-4057qib7 11492 7 followed follow VBN cord-005453-4057qib7 11492 8 by by IN cord-005453-4057qib7 11492 9 G G NNP cord-005453-4057qib7 11492 10 - - HYPH cord-005453-4057qib7 11492 11 CSF CSF NNP cord-005453-4057qib7 11492 12 was be VBD cord-005453-4057qib7 11492 13 used use VBN cord-005453-4057qib7 11492 14 for for IN cord-005453-4057qib7 11492 15 PBSC PBSC NNP cord-005453-4057qib7 11492 16 mobilization mobilization NN cord-005453-4057qib7 11492 17 . . . cord-005453-4057qib7 11493 1 Sevenr Sevenr NNP cord-005453-4057qib7 11493 2 patients patient NNS cord-005453-4057qib7 11493 3 received receive VBD cord-005453-4057qib7 11493 4 conditioning conditioning NN cord-005453-4057qib7 11493 5 regimens regimen NNS cord-005453-4057qib7 11493 6 of of IN cord-005453-4057qib7 11493 7 BEAM(BEAM beam(beam JJ cord-005453-4057qib7 11493 8 group group NN cord-005453-4057qib7 11493 9 ) ) -RRB- cord-005453-4057qib7 11493 10 : : : cord-005453-4057qib7 11493 11 BCNU BCNU NNP cord-005453-4057qib7 11493 12 300mg/ 300mg/ CD cord-005453-4057qib7 11493 13 m m CD cord-005453-4057qib7 11493 14 2 2 CD cord-005453-4057qib7 11493 15 · · NFP cord-005453-4057qib7 11494 1 d d NNP cord-005453-4057qib7 11494 2 -1 -1 NNP cord-005453-4057qib7 11494 3 ×1d ×1d NNP cord-005453-4057qib7 11494 4 ( ( -LRB- cord-005453-4057qib7 11494 5 -7d -7d : cord-005453-4057qib7 11494 6 ) ) -RRB- cord-005453-4057qib7 11494 7 , , . cord-005453-4057qib7 11495 1 VP16 VP16 NNP cord-005453-4057qib7 11495 2 100mg 100mg NNP cord-005453-4057qib7 11495 3 / / SYM cord-005453-4057qib7 11495 4 m m NN cord-005453-4057qib7 11495 5 2 2 CD cord-005453-4057qib7 11495 6 · · NFP cord-005453-4057qib7 11495 7 Q12h×4d q12h×4d XX cord-005453-4057qib7 11495 8 ( ( -LRB- cord-005453-4057qib7 11495 9 -6d--3d -6d--3d NNP cord-005453-4057qib7 11495 10 ) ) -RRB- cord-005453-4057qib7 11495 11 , , . cord-005453-4057qib7 11496 1 Ara Ara NNP cord-005453-4057qib7 11496 2 - - HYPH cord-005453-4057qib7 11496 3 C C NNP cord-005453-4057qib7 11496 4 200mg 200mg NNP cord-005453-4057qib7 11496 5 / / SYM cord-005453-4057qib7 11496 6 m m NN cord-005453-4057qib7 11496 7 2 2 CD cord-005453-4057qib7 11496 8 · · NFP cord-005453-4057qib7 11496 9 q12h×4 q12h×4 NNP cord-005453-4057qib7 11496 10 d d XX cord-005453-4057qib7 11496 11 ( ( -LRB- cord-005453-4057qib7 11497 1 -6d--3d -6d--3d NN cord-005453-4057qib7 11497 2 ) ) -RRB- cord-005453-4057qib7 11497 3 , , , cord-005453-4057qib7 11497 4 Mel Mel NNP cord-005453-4057qib7 11497 5 140mg 140mg NNP cord-005453-4057qib7 11497 6 / / SYM cord-005453-4057qib7 11497 7 m m NN cord-005453-4057qib7 11497 8 2 2 CD cord-005453-4057qib7 11497 9 · · NFP cord-005453-4057qib7 11497 10 d d NN cord-005453-4057qib7 11497 11 -1 -1 NN cord-005453-4057qib7 11497 12 ×1d ×1d NNP cord-005453-4057qib7 11497 13 ( ( -LRB- cord-005453-4057qib7 11497 14 -2d -2d NFP cord-005453-4057qib7 11497 15 ) ) -RRB- cord-005453-4057qib7 11497 16 . . . cord-005453-4057qib7 11498 1 Three three CD cord-005453-4057qib7 11498 2 patients patient NNS cord-005453-4057qib7 11498 3 received receive VBD cord-005453-4057qib7 11498 4 intensive intensive JJ cord-005453-4057qib7 11498 5 preconditioning preconditioning NN cord-005453-4057qib7 11498 6 regimen regimen NN cord-005453-4057qib7 11498 7 containing contain VBG cord-005453-4057qib7 11498 8 cladribine cladribine NNP cord-005453-4057qib7 11498 9 ( ( -LRB- cord-005453-4057qib7 11498 10 CLGB CLGB NNP cord-005453-4057qib7 11498 11 group group NN cord-005453-4057qib7 11498 12 ) ) -RRB- cord-005453-4057qib7 11498 13 : : : cord-005453-4057qib7 11499 1 CLad CLad NNP cord-005453-4057qib7 11499 2 5 5 CD cord-005453-4057qib7 11499 3 mg mg NN cord-005453-4057qib7 11500 1 /m /m NNP cord-005453-4057qib7 11500 2 2 2 LS cord-005453-4057qib7 11500 3 · · NFP cord-005453-4057qib7 11500 4 d d NN cord-005453-4057qib7 11500 5 -1 -1 NNP cord-005453-4057qib7 11501 1 ×5d ×5d NNP cord-005453-4057qib7 11501 2 ( ( -LRB- cord-005453-4057qib7 11501 3 -6d--2d -6d--2d NNP cord-005453-4057qib7 11501 4 ) ) -RRB- cord-005453-4057qib7 11501 5 , , . cord-005453-4057qib7 11502 1 GEM2500mg GEM2500mg NNP cord-005453-4057qib7 11502 2 / / SYM cord-005453-4057qib7 11502 3 m m NN cord-005453-4057qib7 11502 4 2 2 CD cord-005453-4057qib7 11502 5 · · NFP cord-005453-4057qib7 11502 6 d d NN cord-005453-4057qib7 11502 7 -1 -1 NNP cord-005453-4057qib7 11502 8 ×2d ×2d NNP cord-005453-4057qib7 11502 9 ( ( -LRB- cord-005453-4057qib7 11502 10 -6d -6d UH cord-005453-4057qib7 11502 11 , , , cord-005453-4057qib7 11502 12 -2d -2d NNP cord-005453-4057qib7 11502 13 ) ) -RRB- cord-005453-4057qib7 11502 14 , , . cord-005453-4057qib7 11503 1 BU0.8mg BU0.8mg NNP cord-005453-4057qib7 11503 2 / / SYM cord-005453-4057qib7 11503 3 Kg Kg NNP cord-005453-4057qib7 11503 4 Q6h×4d Q6h×4d NNP cord-005453-4057qib7 11503 5 ( ( -LRB- cord-005453-4057qib7 11503 6 -6d--3d -6d--3d NNP cord-005453-4057qib7 11503 7 ) ) -RRB- cord-005453-4057qib7 11503 8 . . . cord-005453-4057qib7 11504 1 Follow follow VB cord-005453-4057qib7 11504 2 - - HYPH cord-005453-4057qib7 11504 3 up up RP cord-005453-4057qib7 11504 4 date date NN cord-005453-4057qib7 11504 5 expires expire VBZ cord-005453-4057qib7 11504 6 on on IN cord-005453-4057qib7 11504 7 December December NNP cord-005453-4057qib7 11504 8 1 1 CD cord-005453-4057qib7 11504 9 , , , cord-005453-4057qib7 11504 10 2018 2018 CD cord-005453-4057qib7 11504 11 . . . cord-005453-4057qib7 11505 1 Results result NNS cord-005453-4057qib7 11505 2 : : : cord-005453-4057qib7 11506 1 The the DT cord-005453-4057qib7 11506 2 age age NN cord-005453-4057qib7 11506 3 of of IN cord-005453-4057qib7 11506 4 3 3 CD cord-005453-4057qib7 11506 5 patients patient NNS cord-005453-4057qib7 11506 6 in in IN cord-005453-4057qib7 11506 7 CLGB CLGB NNP cord-005453-4057qib7 11506 8 group group NN cord-005453-4057qib7 11506 9 was be VBD cord-005453-4057qib7 11506 10 41 41 CD cord-005453-4057qib7 11506 11 , , , cord-005453-4057qib7 11506 12 12 12 CD cord-005453-4057qib7 11506 13 and and CC cord-005453-4057qib7 11506 14 50 50 CD cord-005453-4057qib7 11506 15 years year NNS cord-005453-4057qib7 11506 16 , , , cord-005453-4057qib7 11506 17 respectively respectively RB cord-005453-4057qib7 11506 18 . . . cord-005453-4057qib7 11507 1 Two two CD cord-005453-4057qib7 11507 2 patients patient NNS cord-005453-4057qib7 11507 3 were be VBD cord-005453-4057qib7 11507 4 diagnosed diagnose VBN cord-005453-4057qib7 11507 5 as as IN cord-005453-4057qib7 11507 6 diffuse diffuse JJ cord-005453-4057qib7 11507 7 large large JJ cord-005453-4057qib7 11507 8 B b NN cord-005453-4057qib7 11507 9 - - HYPH cord-005453-4057qib7 11507 10 cell cell NN cord-005453-4057qib7 11507 11 lymphoma lymphoma NN cord-005453-4057qib7 11507 12 with with IN cord-005453-4057qib7 11507 13 double double JJ cord-005453-4057qib7 11507 14 expression expression NN cord-005453-4057qib7 11507 15 and and CC cord-005453-4057qib7 11507 16 one one NN cord-005453-4057qib7 11507 17 was be VBD cord-005453-4057qib7 11507 18 diffuse diffuse JJ cord-005453-4057qib7 11507 19 large large JJ cord-005453-4057qib7 11507 20 B b NN cord-005453-4057qib7 11507 21 - - HYPH cord-005453-4057qib7 11507 22 cell cell NN cord-005453-4057qib7 11507 23 lymphoma lymphoma NN cord-005453-4057qib7 11507 24 with with IN cord-005453-4057qib7 11507 25 two two CD cord-005453-4057qib7 11507 26 recurrences recurrence NNS cord-005453-4057qib7 11507 27 . . . cord-005453-4057qib7 11508 1 The the DT cord-005453-4057qib7 11508 2 patients patient NNS cord-005453-4057qib7 11508 3 of of IN cord-005453-4057qib7 11508 4 BEAM BEAM NNP cord-005453-4057qib7 11508 5 group group NN cord-005453-4057qib7 11508 6 were be VBD cord-005453-4057qib7 11508 7 all all DT cord-005453-4057qib7 11508 8 high high JJ cord-005453-4057qib7 11508 9 - - HYPH cord-005453-4057qib7 11508 10 risk risk NN cord-005453-4057qib7 11508 11 , , , cord-005453-4057qib7 11508 12 relapsed relapsed JJ cord-005453-4057qib7 11508 13 and and CC cord-005453-4057qib7 11508 14 refractory refractory JJ cord-005453-4057qib7 11508 15 NHL.All NHL.All NNP cord-005453-4057qib7 11508 16 patients patient NNS cord-005453-4057qib7 11508 17 were be VBD cord-005453-4057qib7 11508 18 successfully successfully RB cord-005453-4057qib7 11508 19 engrafted engraft VBN cord-005453-4057qib7 11508 20 after after IN cord-005453-4057qib7 11508 21 infusing infuse VBG cord-005453-4057qib7 11508 22 APBSC APBSC NNS cord-005453-4057qib7 11508 23 . . . cord-005453-4057qib7 11509 1 The the DT cord-005453-4057qib7 11509 2 average average JJ cord-005453-4057qib7 11509 3 lowest low JJS cord-005453-4057qib7 11509 4 leukocyte leukocyte NN cord-005453-4057qib7 11509 5 in in IN cord-005453-4057qib7 11509 6 CLGB CLGB NNP cord-005453-4057qib7 11509 7 group group NN cord-005453-4057qib7 11509 8 and and CC cord-005453-4057qib7 11509 9 BEAM BEAM NNP cord-005453-4057qib7 11509 10 group group NN cord-005453-4057qib7 11509 11 were be VBD cord-005453-4057qib7 11509 12 ( ( -LRB- cord-005453-4057qib7 11509 13 0.023 0.023 CD cord-005453-4057qib7 11509 14 ±0.023 ±0.023 NN cord-005453-4057qib7 11509 15 ) ) -RRB- cord-005453-4057qib7 11510 1 ×10 ×10 NNS cord-005453-4057qib7 11510 2 9 9 CD cord-005453-4057qib7 11510 3 /L /L , cord-005453-4057qib7 11510 4 VS VS NNP cord-005453-4057qib7 11510 5 ( ( -LRB- cord-005453-4057qib7 11510 6 0.237±0.2033)×10 0.237±0.2033)×10 CD cord-005453-4057qib7 11510 7 9 9 CD cord-005453-4057qib7 11510 8 /L /l CD cord-005453-4057qib7 11510 9 , , , cord-005453-4057qib7 11510 10 respectively respectively RB cord-005453-4057qib7 11510 11 . . . cord-005453-4057qib7 11511 1 The the DT cord-005453-4057qib7 11511 2 average average JJ cord-005453-4057qib7 11511 3 lowest low JJS cord-005453-4057qib7 11511 4 leukocyte leukocyte NN cord-005453-4057qib7 11511 5 in in IN cord-005453-4057qib7 11511 6 CLGB CLGB NNP cord-005453-4057qib7 11511 7 group group NN cord-005453-4057qib7 11511 8 was be VBD cord-005453-4057qib7 11511 9 lower low JJR cord-005453-4057qib7 11511 10 than than IN cord-005453-4057qib7 11511 11 that that DT cord-005453-4057qib7 11511 12 in in IN cord-005453-4057qib7 11511 13 BEAM BEAM NNP cord-005453-4057qib7 11511 14 group group NN cord-005453-4057qib7 11511 15 . . . cord-005453-4057qib7 11512 1 The the DT cord-005453-4057qib7 11512 2 average average JJ cord-005453-4057qib7 11512 3 time time NN cord-005453-4057qib7 11512 4 to to IN cord-005453-4057qib7 11512 5 ANC ANC NNP cord-005453-4057qib7 11512 6 < < XX cord-005453-4057qib7 11512 7 0.5×109 0.5×109 ADD cord-005453-4057qib7 11513 1 / / NFP cord-005453-4057qib7 11514 1 L L NNP cord-005453-4057qib7 11514 2 in in IN cord-005453-4057qib7 11514 3 CLGB CLGB NNP cord-005453-4057qib7 11514 4 group group NN cord-005453-4057qib7 11514 5 and and CC cord-005453-4057qib7 11514 6 BEAM BEAM NNP cord-005453-4057qib7 11514 7 group group NN cord-005453-4057qib7 11514 8 were be VBD cord-005453-4057qib7 11514 9 1.33d 1.33d CD cord-005453-4057qib7 11514 10 ±1.53d ±1.53d NN cord-005453-4057qib7 11514 11 VS VS NNP cord-005453-4057qib7 11514 12 3.57d±2.07d 3.57d±2.07d CD cord-005453-4057qib7 11514 13 . . . cord-005453-4057qib7 11515 1 The the DT cord-005453-4057qib7 11515 2 average average JJ cord-005453-4057qib7 11515 3 time time NN cord-005453-4057qib7 11515 4 to to IN cord-005453-4057qib7 11515 5 ANC≥0.5×10 anc≥0.5×10 NN cord-005453-4057qib7 11515 6 9 9 CD cord-005453-4057qib7 11515 7 /L /L . cord-005453-4057qib7 11515 8 in in IN cord-005453-4057qib7 11515 9 CLGB CLGB NNP cord-005453-4057qib7 11515 10 group group NN cord-005453-4057qib7 11515 11 and and CC cord-005453-4057qib7 11515 12 BEAM BEAM NNP cord-005453-4057qib7 11515 13 group group NN cord-005453-4057qib7 11515 14 were be VBD cord-005453-4057qib7 11515 15 9.0d±1.0d 9.0d±1.0d CD cord-005453-4057qib7 11515 16 VS VS NNP cord-005453-4057qib7 11515 17 10.0d±2.6d 10.0d±2.6d CD cord-005453-4057qib7 11515 18 ; ; : cord-005453-4057qib7 11515 19 The the DT cord-005453-4057qib7 11515 20 average average JJ cord-005453-4057qib7 11515 21 time time NN cord-005453-4057qib7 11515 22 to to IN cord-005453-4057qib7 11515 23 PLT≥20×10 PLT≥20×10 NNP cord-005453-4057qib7 11515 24 9 9 CD cord-005453-4057qib7 11515 25 /L /l CD cord-005453-4057qib7 11515 26 of of IN cord-005453-4057qib7 11515 27 CLGB CLGB NNP cord-005453-4057qib7 11515 28 group group NN cord-005453-4057qib7 11515 29 was be VBD cord-005453-4057qib7 11515 30 not not RB cord-005453-4057qib7 11515 31 different different JJ cord-005453-4057qib7 11515 32 to to IN cord-005453-4057qib7 11515 33 that that DT cord-005453-4057qib7 11515 34 of of IN cord-005453-4057qib7 11515 35 BEAM BEAM NNP cord-005453-4057qib7 11515 36 group group NN cord-005453-4057qib7 11515 37 ( ( -LRB- cord-005453-4057qib7 11515 38 8.0d±1.0d 8.0d±1.0d IN cord-005453-4057qib7 11515 39 VS VS NNP cord-005453-4057qib7 11515 40 9.6d±2.2d 9.6d±2.2d CD cord-005453-4057qib7 11515 41 ) ) -RRB- cord-005453-4057qib7 11516 1 the the DT cord-005453-4057qib7 11516 2 average average JJ cord-005453-4057qib7 11516 3 time time NN cord-005453-4057qib7 11516 4 of of IN cord-005453-4057qib7 11516 5 neutropenia neutropenia NN cord-005453-4057qib7 11516 6 was be VBD cord-005453-4057qib7 11516 7 n't not RB cord-005453-4057qib7 11516 8 significantly significantly RB cord-005453-4057qib7 11516 9 different different JJ cord-005453-4057qib7 11516 10 in in IN cord-005453-4057qib7 11516 11 two two CD cord-005453-4057qib7 11516 12 groups group NNS cord-005453-4057qib7 11516 13 ( ( -LRB- cord-005453-4057qib7 11516 14 8.33d±3.1d 8.33d±3.1d CD cord-005453-4057qib7 11516 15 VS VS NNP cord-005453-4057qib7 11516 16 8.0d±2.1d 8.0d±2.1d NN cord-005453-4057qib7 11516 17 ) ) -RRB- cord-005453-4057qib7 11516 18 . . . cord-005453-4057qib7 11517 1 The the DT cord-005453-4057qib7 11517 2 adverse adverse JJ cord-005453-4057qib7 11517 3 reactions reaction NNS cord-005453-4057qib7 11517 4 of of IN cord-005453-4057qib7 11517 5 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 11517 6 tract tract NN cord-005453-4057qib7 11517 7 and and CC cord-005453-4057qib7 11517 8 oral oral JJ cord-005453-4057qib7 11517 9 mucosa mucosa NN cord-005453-4057qib7 11517 10 were be VBD cord-005453-4057qib7 11517 11 close close JJ cord-005453-4057qib7 11517 12 in in IN cord-005453-4057qib7 11517 13 tow tow NN cord-005453-4057qib7 11517 14 groups group NNS cord-005453-4057qib7 11517 15 . . . cord-005453-4057qib7 11518 1 VOD VOD NNP cord-005453-4057qib7 11518 2 , , , cord-005453-4057qib7 11518 3 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 11518 4 cystitis cystitis NN cord-005453-4057qib7 11518 5 , , , cord-005453-4057qib7 11518 6 pretreatment pretreatment NN cord-005453-4057qib7 11518 7 - - HYPH cord-005453-4057qib7 11518 8 related relate VBN cord-005453-4057qib7 11518 9 interstitial interstitial JJ cord-005453-4057qib7 11518 10 pneumonia pneumonia NN cord-005453-4057qib7 11518 11 , , , cord-005453-4057qib7 11518 12 Liver liver NN cord-005453-4057qib7 11518 13 and and CC cord-005453-4057qib7 11518 14 kidney kidney NN cord-005453-4057qib7 11518 15 dysfunction dysfunction NN cord-005453-4057qib7 11518 16 were be VBD cord-005453-4057qib7 11518 17 not not RB cord-005453-4057qib7 11518 18 happened happen VBN cord-005453-4057qib7 11518 19 in in IN cord-005453-4057qib7 11518 20 tow tow NN cord-005453-4057qib7 11518 21 groups group NNS cord-005453-4057qib7 11518 22 . . . cord-005453-4057qib7 11519 1 The the DT cord-005453-4057qib7 11519 2 rate rate NN cord-005453-4057qib7 11519 3 of of IN cord-005453-4057qib7 11519 4 infectious infectious JJ cord-005453-4057qib7 11519 5 fever fever NN cord-005453-4057qib7 11519 6 was be VBD cord-005453-4057qib7 11519 7 close close JJ cord-005453-4057qib7 11519 8 in in IN cord-005453-4057qib7 11519 9 two two CD cord-005453-4057qib7 11519 10 groups group NNS cord-005453-4057qib7 11519 11 ( ( -LRB- cord-005453-4057qib7 11519 12 2/3 2/3 CD cord-005453-4057qib7 11519 13 VS VS NNP cord-005453-4057qib7 11519 14 4/7 4/7 CD cord-005453-4057qib7 11519 15 ) ) -RRB- cord-005453-4057qib7 11519 16 . . . cord-005453-4057qib7 11520 1 The the DT cord-005453-4057qib7 11520 2 median median JJ cord-005453-4057qib7 11520 3 followup followup JJ cord-005453-4057qib7 11520 4 period period NN cord-005453-4057qib7 11520 5 in in IN cord-005453-4057qib7 11520 6 BEAM BEAM NNP cord-005453-4057qib7 11520 7 group group NN cord-005453-4057qib7 11520 8 was be VBD cord-005453-4057qib7 11520 9 9 9 CD cord-005453-4057qib7 11520 10 ( ( -LRB- cord-005453-4057qib7 11520 11 1~19 1~19 CD cord-005453-4057qib7 11520 12 ) ) -RRB- cord-005453-4057qib7 11520 13 months month NNS cord-005453-4057qib7 11520 14 . . . cord-005453-4057qib7 11521 1 In in IN cord-005453-4057qib7 11521 2 the the DT cord-005453-4057qib7 11521 3 BEAM BEAM NNP cord-005453-4057qib7 11521 4 group group NN cord-005453-4057qib7 11521 5 , , , cord-005453-4057qib7 11521 6 a a DT cord-005453-4057qib7 11521 7 patient patient NN cord-005453-4057qib7 11521 8 died die VBD cord-005453-4057qib7 11521 9 20 20 CD cord-005453-4057qib7 11521 10 days day NNS cord-005453-4057qib7 11521 11 after after IN cord-005453-4057qib7 11521 12 transplantation transplantation NN cord-005453-4057qib7 11521 13 , , , cord-005453-4057qib7 11521 14 because because IN cord-005453-4057qib7 11521 15 he -PRON- PRP cord-005453-4057qib7 11521 16 was be VBD cord-005453-4057qib7 11521 17 diagnosed diagnose VBN cord-005453-4057qib7 11521 18 with with IN cord-005453-4057qib7 11521 19 recurrent recurrent JJ cord-005453-4057qib7 11521 20 NKT NKT NNP cord-005453-4057qib7 11521 21 cell cell NN cord-005453-4057qib7 11521 22 lymphoma lymphoma NN cord-005453-4057qib7 11521 23 and and CC cord-005453-4057qib7 11521 24 intracranial intracranial JJ cord-005453-4057qib7 11521 25 infection infection NN cord-005453-4057qib7 11521 26 caused cause VBN cord-005453-4057qib7 11521 27 by by IN cord-005453-4057qib7 11521 28 severe severe JJ cord-005453-4057qib7 11521 29 sinus sinus NN cord-005453-4057qib7 11521 30 infection infection NN cord-005453-4057qib7 11521 31 . . . cord-005453-4057qib7 11522 1 Another another DT cord-005453-4057qib7 11522 2 case case NN cord-005453-4057qib7 11522 3 of of IN cord-005453-4057qib7 11522 4 BEAM BEAM NNP cord-005453-4057qib7 11522 5 group group NN cord-005453-4057qib7 11522 6 was be VBD cord-005453-4057qib7 11522 7 diagnosed diagnose VBN cord-005453-4057qib7 11522 8 as as IN cord-005453-4057qib7 11522 9 double double RB cord-005453-4057qib7 11522 10 - - HYPH cord-005453-4057qib7 11522 11 expressed express VBN cord-005453-4057qib7 11522 12 DLBCL DLBCL NNP cord-005453-4057qib7 11522 13 , , , cord-005453-4057qib7 11522 14 which which WDT cord-005453-4057qib7 11522 15 relapsed relapse VBD cord-005453-4057qib7 11522 16 3 3 CD cord-005453-4057qib7 11522 17 months month NNS cord-005453-4057qib7 11522 18 after after IN cord-005453-4057qib7 11522 19 transplantation transplantation NN cord-005453-4057qib7 11522 20 . . . cord-005453-4057qib7 11523 1 The the DT cord-005453-4057qib7 11523 2 remaining remain VBG cord-005453-4057qib7 11523 3 patients patient NNS cord-005453-4057qib7 11523 4 in in IN cord-005453-4057qib7 11523 5 EBMT EBMT NNP cord-005453-4057qib7 11523 6 group group NN cord-005453-4057qib7 11523 7 survived survive VBD cord-005453-4057qib7 11523 8 disease disease NN cord-005453-4057qib7 11523 9 - - HYPH cord-005453-4057qib7 11523 10 free free JJ cord-005453-4057qib7 11523 11 . . . cord-005453-4057qib7 11524 1 The the DT cord-005453-4057qib7 11524 2 follow follow VB cord-005453-4057qib7 11524 3 - - HYPH cord-005453-4057qib7 11524 4 up up NN cord-005453-4057qib7 11524 5 time time NN cord-005453-4057qib7 11524 6 of of IN cord-005453-4057qib7 11524 7 3 3 CD cord-005453-4057qib7 11524 8 patients patient NNS cord-005453-4057qib7 11524 9 in in IN cord-005453-4057qib7 11524 10 CLGB CLGB NNP cord-005453-4057qib7 11524 11 group group NN cord-005453-4057qib7 11524 12 were be VBD cord-005453-4057qib7 11524 13 2 2 CD cord-005453-4057qib7 11524 14 months month NNS cord-005453-4057qib7 11524 15 , , , cord-005453-4057qib7 11524 16 3 3 CD cord-005453-4057qib7 11524 17 months month NNS cord-005453-4057qib7 11524 18 and and CC cord-005453-4057qib7 11524 19 9 9 CD cord-005453-4057qib7 11524 20 months month NNS cord-005453-4057qib7 11524 21 respectively respectively RB cord-005453-4057qib7 11524 22 . . . cord-005453-4057qib7 11525 1 All all DT cord-005453-4057qib7 11525 2 patients patient NNS cord-005453-4057qib7 11525 3 survived survive VBD cord-005453-4057qib7 11525 4 without without IN cord-005453-4057qib7 11525 5 disease disease NN cord-005453-4057qib7 11525 6 . . . cord-005453-4057qib7 11526 1 However however RB cord-005453-4057qib7 11526 2 , , , cord-005453-4057qib7 11526 3 the the DT cord-005453-4057qib7 11526 4 follow follow NN cord-005453-4057qib7 11526 5 - - HYPH cord-005453-4057qib7 11526 6 up up NN cord-005453-4057qib7 11526 7 time time NN cord-005453-4057qib7 11526 8 is be VBZ cord-005453-4057qib7 11526 9 short short JJ cord-005453-4057qib7 11526 10 and and CC cord-005453-4057qib7 11526 11 needs need VBZ cord-005453-4057qib7 11526 12 long long JJ cord-005453-4057qib7 11526 13 - - HYPH cord-005453-4057qib7 11526 14 term term NN cord-005453-4057qib7 11526 15 follow follow NN cord-005453-4057qib7 11526 16 - - HYPH cord-005453-4057qib7 11526 17 up up NN cord-005453-4057qib7 11526 18 . . . cord-005453-4057qib7 11527 1 Conclusions conclusion NNS cord-005453-4057qib7 11527 2 : : : cord-005453-4057qib7 11528 1 The the DT cord-005453-4057qib7 11528 2 treatment treatment NN cord-005453-4057qib7 11528 3 of of IN cord-005453-4057qib7 11528 4 intensive intensive JJ cord-005453-4057qib7 11528 5 preconditioning preconditioning NN cord-005453-4057qib7 11528 6 regimen regimen NN cord-005453-4057qib7 11528 7 containing contain VBG cord-005453-4057qib7 11528 8 Cladribine Cladribine NNP cord-005453-4057qib7 11528 9 ( ( -LRB- cord-005453-4057qib7 11528 10 CLGB CLGB NNP cord-005453-4057qib7 11528 11 ) ) -RRB- cord-005453-4057qib7 11528 12 for for IN cord-005453-4057qib7 11528 13 refractory refractory JJ cord-005453-4057qib7 11528 14 and and CC cord-005453-4057qib7 11528 15 relapsed relapse VBD cord-005453-4057qib7 11528 16 young young JJ cord-005453-4057qib7 11528 17 highly highly RB cord-005453-4057qib7 11528 18 invasive invasive JJ cord-005453-4057qib7 11528 19 lymphoma lymphoma NN cord-005453-4057qib7 11528 20 undergoing undergo VBG cord-005453-4057qib7 11528 21 APBSCT APBSCT NNP cord-005453-4057qib7 11528 22 is be VBZ cord-005453-4057qib7 11528 23 safe safe JJ cord-005453-4057qib7 11528 24 . . . cord-005453-4057qib7 11529 1 The the DT cord-005453-4057qib7 11529 2 time time NN cord-005453-4057qib7 11529 3 of of IN cord-005453-4057qib7 11529 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 11529 5 reconstruction reconstruction NN cord-005453-4057qib7 11529 6 is be VBZ cord-005453-4057qib7 11529 7 short short JJ cord-005453-4057qib7 11529 8 , , , cord-005453-4057qib7 11529 9 and and CC cord-005453-4057qib7 11529 10 the the DT cord-005453-4057qib7 11529 11 adverse adverse JJ cord-005453-4057qib7 11529 12 effects effect NNS cord-005453-4057qib7 11529 13 is be VBZ cord-005453-4057qib7 11529 14 tolerable tolerable JJ cord-005453-4057qib7 11529 15 for for IN cord-005453-4057qib7 11529 16 patients patient NNS cord-005453-4057qib7 11529 17 with with IN cord-005453-4057qib7 11529 18 refractory refractory JJ cord-005453-4057qib7 11529 19 and and CC cord-005453-4057qib7 11529 20 relapsed relapse VBD cord-005453-4057qib7 11529 21 young young JJ cord-005453-4057qib7 11529 22 highly highly RB cord-005453-4057qib7 11529 23 invasive invasive JJ cord-005453-4057qib7 11529 24 lymphoma lymphoma NN cord-005453-4057qib7 11529 25 . . . cord-005453-4057qib7 11530 1 The the DT cord-005453-4057qib7 11530 2 current current JJ cord-005453-4057qib7 11530 3 short short JJ cord-005453-4057qib7 11530 4 - - HYPH cord-005453-4057qib7 11530 5 term term NN cord-005453-4057qib7 11530 6 outcome outcome NN cord-005453-4057qib7 11530 7 is be VBZ cord-005453-4057qib7 11530 8 good good JJ cord-005453-4057qib7 11530 9 , , , cord-005453-4057qib7 11530 10 but but CC cord-005453-4057qib7 11530 11 the the DT cord-005453-4057qib7 11530 12 long long JJ cord-005453-4057qib7 11530 13 - - HYPH cord-005453-4057qib7 11530 14 term term NN cord-005453-4057qib7 11530 15 effect effect NN cord-005453-4057qib7 11530 16 need need VBP cord-005453-4057qib7 11530 17 a a DT cord-005453-4057qib7 11530 18 longer long JJR cord-005453-4057qib7 11530 19 time time NN cord-005453-4057qib7 11530 20 to to TO cord-005453-4057qib7 11530 21 follow follow VB cord-005453-4057qib7 11530 22 - - HYPH cord-005453-4057qib7 11530 23 up up NN cord-005453-4057qib7 11530 24 . . . cord-005453-4057qib7 11531 1 Disclosure disclosure NN cord-005453-4057qib7 11531 2 : : : cord-005453-4057qib7 11532 1 This this DT cord-005453-4057qib7 11532 2 work work NN cord-005453-4057qib7 11532 3 was be VBD cord-005453-4057qib7 11532 4 supported support VBN cord-005453-4057qib7 11532 5 by by IN cord-005453-4057qib7 11532 6 National National NNP cord-005453-4057qib7 11532 7 Nature Nature NNP cord-005453-4057qib7 11532 8 Sciences Sciences NNPS cord-005453-4057qib7 11532 9 Found find VBN cord-005453-4057qib7 11532 10 of of IN cord-005453-4057qib7 11532 11 China China NNP cord-005453-4057qib7 11532 12 ( ( -LRB- cord-005453-4057qib7 11532 13 81300417 81300417 CD cord-005453-4057qib7 11532 14 ) ) -RRB- cord-005453-4057qib7 11532 15 . . . cord-005453-4057qib7 11533 1 There there EX cord-005453-4057qib7 11533 2 is be VBZ cord-005453-4057qib7 11533 3 no no DT cord-005453-4057qib7 11533 4 disclosure disclosure NN cord-005453-4057qib7 11533 5 of of IN cord-005453-4057qib7 11533 6 conflict conflict NN cord-005453-4057qib7 11533 7 of of IN cord-005453-4057qib7 11533 8 interest interest NN cord-005453-4057qib7 11533 9 . . . cord-005453-4057qib7 11534 1 The the DT cord-005453-4057qib7 11534 2 all all DT cord-005453-4057qib7 11534 3 authors author NNS cord-005453-4057qib7 11534 4 name name VBP cord-005453-4057qib7 11534 5 : : : cord-005453-4057qib7 11535 1 Xiang Xiang NNP cord-005453-4057qib7 11535 2 - - HYPH cord-005453-4057qib7 11535 3 Li Li NNP cord-005453-4057qib7 11535 4 Chen Chen NNP cord-005453-4057qib7 11535 5 , , , cord-005453-4057qib7 11535 6 Yu Yu NNP cord-005453-4057qib7 11535 7 - - HYPH cord-005453-4057qib7 11535 8 Zhu Zhu NNP cord-005453-4057qib7 11535 9 Zang Zang NNP cord-005453-4057qib7 11535 10 , , , cord-005453-4057qib7 11535 11 Wen Wen NNP cord-005453-4057qib7 11535 12 - - HYPH cord-005453-4057qib7 11535 13 Hui Hui NNP cord-005453-4057qib7 11535 14 Zhang Zhang NNP cord-005453-4057qib7 11535 15 , , , cord-005453-4057qib7 11535 16 Yin Yin NNP cord-005453-4057qib7 11535 17 Zhang Zhang NNP cord-005453-4057qib7 11535 18 , , , cord-005453-4057qib7 11535 19 Zhong Zhong NNP cord-005453-4057qib7 11535 20 - - HYPH cord-005453-4057qib7 11535 21 Wen Wen NNP cord-005453-4057qib7 11535 22 Liu Liu NNP cord-005453-4057qib7 11535 23 , , , cord-005453-4057qib7 11535 24 Ping Ping NNP cord-005453-4057qib7 11535 25 - - HYPH cord-005453-4057qib7 11535 26 Chong Chong NNP cord-005453-4057qib7 11535 27 Lei Lei NNP cord-005453-4057qib7 11535 28 , , , cord-005453-4057qib7 11535 29 Jing Jing NNP cord-005453-4057qib7 11535 30 Yang Yang NNP cord-005453-4057qib7 11535 31 , , , cord-005453-4057qib7 11535 32 Yu Yu NNP cord-005453-4057qib7 11535 33 - - HYPH cord-005453-4057qib7 11535 34 Qing Qing NNP cord-005453-4057qib7 11535 35 Chen Chen NNP cord-005453-4057qib7 11535 36 , , , cord-005453-4057qib7 11535 37 Kai Kai NNP cord-005453-4057qib7 11535 38 Sun Sun NNP cord-005453-4057qib7 11535 39 . . . cord-005453-4057qib7 11536 1 Background background NN cord-005453-4057qib7 11536 2 : : : cord-005453-4057qib7 11537 1 Small small JJ cord-005453-4057qib7 11537 2 part part NN cord-005453-4057qib7 11537 3 of of IN cord-005453-4057qib7 11537 4 children child NNS cord-005453-4057qib7 11537 5 with with IN cord-005453-4057qib7 11537 6 Hodgkin Hodgkin NNP cord-005453-4057qib7 11537 7 Disease Disease NNP cord-005453-4057qib7 11537 8 ( ( -LRB- cord-005453-4057qib7 11537 9 HD HD NNP cord-005453-4057qib7 11537 10 ) ) -RRB- cord-005453-4057qib7 11537 11 demonstrate demonstrate VB cord-005453-4057qib7 11537 12 initial initial JJ cord-005453-4057qib7 11537 13 resistance resistance NN cord-005453-4057qib7 11537 14 to to IN cord-005453-4057qib7 11537 15 the the DT cord-005453-4057qib7 11537 16 standard standard NN cord-005453-4057qib7 11537 17 and and CC cord-005453-4057qib7 11537 18 even even RB cord-005453-4057qib7 11537 19 " " `` cord-005453-4057qib7 11537 20 salvage salvage VB cord-005453-4057qib7 11537 21 " " '' cord-005453-4057qib7 11537 22 chemotherapy chemotherapy NN cord-005453-4057qib7 11537 23 and and CC cord-005453-4057qib7 11537 24 need need VB cord-005453-4057qib7 11537 25 innovative innovative JJ cord-005453-4057qib7 11537 26 drugs drug NNS cord-005453-4057qib7 11537 27 for for IN cord-005453-4057qib7 11537 28 the the DT cord-005453-4057qib7 11537 29 treatment treatment NN cord-005453-4057qib7 11537 30 . . . cord-005453-4057qib7 11538 1 Methods method NNS cord-005453-4057qib7 11538 2 : : : cord-005453-4057qib7 11538 3 A a DT cord-005453-4057qib7 11538 4 15-year 15-year JJ cord-005453-4057qib7 11538 5 girl girl NN cord-005453-4057qib7 11538 6 was be VBD cord-005453-4057qib7 11538 7 diagnosed diagnose VBN cord-005453-4057qib7 11538 8 with with IN cord-005453-4057qib7 11538 9 classical classical JJ cord-005453-4057qib7 11538 10 HD hd NN cord-005453-4057qib7 11538 11 ( ( -LRB- cord-005453-4057qib7 11538 12 nodular nodular JJ cord-005453-4057qib7 11538 13 sclerosis)corresponding sclerosis)corresponding NNP cord-005453-4057qib7 11538 14 to to TO cord-005453-4057qib7 11538 15 stage stage NN cord-005453-4057qib7 11538 16 II II NNP cord-005453-4057qib7 11538 17 E e NN cord-005453-4057qib7 11538 18 B b NN cord-005453-4057qib7 11538 19 ( ( -LRB- cord-005453-4057qib7 11538 20 fever fever NN cord-005453-4057qib7 11538 21 > > XX cord-005453-4057qib7 11538 22 38 38 CD cord-005453-4057qib7 11538 23 ° ° NN cord-005453-4057qib7 11538 24 C c NN cord-005453-4057qib7 11538 25 ) ) -RRB- cord-005453-4057qib7 11538 26 in in IN cord-005453-4057qib7 11538 27 April April NNP cord-005453-4057qib7 11538 28 2016.After 2016.after CD cord-005453-4057qib7 11539 1 two two CD cord-005453-4057qib7 11539 2 cycles cycle NNS cord-005453-4057qib7 11539 3 of of IN cord-005453-4057qib7 11539 4 OEPA OEPA NNP cord-005453-4057qib7 11539 5 ( ( -LRB- cord-005453-4057qib7 11539 6 vincristine vincristine NN cord-005453-4057qib7 11539 7 , , , cord-005453-4057qib7 11539 8 etoposide etoposide RB cord-005453-4057qib7 11539 9 , , , cord-005453-4057qib7 11539 10 prednisone prednisone NN cord-005453-4057qib7 11539 11 and and CC cord-005453-4057qib7 11539 12 doxorubicin doxorubicin NN cord-005453-4057qib7 11539 13 ) ) -RRB- cord-005453-4057qib7 11539 14 and and CC cord-005453-4057qib7 11539 15 next next JJ cord-005453-4057qib7 11539 16 two two CD cord-005453-4057qib7 11539 17 cycles cycle NNS cord-005453-4057qib7 11539 18 COPP COPP NNP cord-005453-4057qib7 11539 19 ( ( -LRB- cord-005453-4057qib7 11539 20 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 11539 21 , , , cord-005453-4057qib7 11539 22 vincristine vincristine NN cord-005453-4057qib7 11539 23 , , , cord-005453-4057qib7 11539 24 prednisone prednisone NN cord-005453-4057qib7 11539 25 and and CC cord-005453-4057qib7 11539 26 procarbazine procarbazine NN cord-005453-4057qib7 11539 27 ) ) -RRB- cord-005453-4057qib7 11540 1 the the DT cord-005453-4057qib7 11540 2 patient patient NN cord-005453-4057qib7 11540 3 again again RB cord-005453-4057qib7 11540 4 had have VBD cord-005453-4057qib7 11540 5 progressive progressive JJ cord-005453-4057qib7 11540 6 disease disease NN cord-005453-4057qib7 11540 7 . . . cord-005453-4057qib7 11541 1 As as IN cord-005453-4057qib7 11541 2 the the DT cord-005453-4057qib7 11541 3 patient patient NN cord-005453-4057qib7 11541 4 achieved achieve VBD cord-005453-4057qib7 11541 5 a a DT cord-005453-4057qib7 11541 6 partial partial JJ cord-005453-4057qib7 11541 7 response response NN cord-005453-4057qib7 11541 8 ( ( -LRB- cord-005453-4057qib7 11541 9 PR PR NNP cord-005453-4057qib7 11541 10 ) ) -RRB- cord-005453-4057qib7 11541 11 after after IN cord-005453-4057qib7 11541 12 " " `` cord-005453-4057qib7 11541 13 Salvage"therapy Salvage"therapy NNP cord-005453-4057qib7 11541 14 with with IN cord-005453-4057qib7 11541 15 two two CD cord-005453-4057qib7 11541 16 cycles cycle NNS cord-005453-4057qib7 11541 17 of of IN cord-005453-4057qib7 11541 18 IGEV IGEV NNP cord-005453-4057qib7 11541 19 ( ( -LRB- cord-005453-4057qib7 11541 20 ifosfamide ifosfamide NNP cord-005453-4057qib7 11541 21 , , , cord-005453-4057qib7 11541 22 gemcitabine gemcitabine NNP cord-005453-4057qib7 11541 23 , , , cord-005453-4057qib7 11541 24 vinorelbine vinorelbine NNP cord-005453-4057qib7 11541 25 , , , cord-005453-4057qib7 11541 26 and and CC cord-005453-4057qib7 11541 27 prednisone prednisone NNP cord-005453-4057qib7 11541 28 ) ) -RRB- cord-005453-4057qib7 11541 29 , , , cord-005453-4057qib7 11541 30 she -PRON- PRP cord-005453-4057qib7 11541 31 received receive VBD cord-005453-4057qib7 11541 32 auto auto NN cord-005453-4057qib7 11541 33 - - HYPH cord-005453-4057qib7 11541 34 SCT SCT NNP cord-005453-4057qib7 11541 35 in in IN cord-005453-4057qib7 11541 36 February February NNP cord-005453-4057qib7 11541 37 2017 2017 CD cord-005453-4057qib7 11541 38 ( ( -LRB- cord-005453-4057qib7 11541 39 patient patient JJ cord-005453-4057qib7 11541 40 status status NN cord-005453-4057qib7 11541 41 before before IN cord-005453-4057qib7 11541 42 auto auto NN cord-005453-4057qib7 11541 43 - - HYPH cord-005453-4057qib7 11541 44 SCT SCT NNP cord-005453-4057qib7 11541 45 was be VBD cord-005453-4057qib7 11541 46 PR PR NNP cord-005453-4057qib7 11541 47 ) ) -RRB- cord-005453-4057qib7 11541 48 . . . cord-005453-4057qib7 11542 1 We -PRON- PRP cord-005453-4057qib7 11542 2 used use VBD cord-005453-4057qib7 11542 3 CCNU CCNU NNP cord-005453-4057qib7 11542 4 - - HYPH cord-005453-4057qib7 11542 5 containing contain VBG cord-005453-4057qib7 11542 6 conditioning conditioning NN cord-005453-4057qib7 11542 7 regimen regimen NN cord-005453-4057qib7 11542 8 CEM CEM NNP cord-005453-4057qib7 11542 9 : : : cord-005453-4057qib7 11543 1 Lomustine Lomustine NNP cord-005453-4057qib7 11543 2 ( ( -LRB- cord-005453-4057qib7 11543 3 CCNU CCNU NNP cord-005453-4057qib7 11543 4 ) ) -RRB- cord-005453-4057qib7 11544 1 300 300 CD cord-005453-4057qib7 11545 1 mg mg NNP cord-005453-4057qib7 11545 2 / / SYM cord-005453-4057qib7 11545 3 m m NNP cord-005453-4057qib7 11545 4 2 2 CD cord-005453-4057qib7 11545 5 + + CC cord-005453-4057qib7 11546 1 Etoposide etoposide RB cord-005453-4057qib7 11546 2 1200 1200 CD cord-005453-4057qib7 11547 1 mg mg NNP cord-005453-4057qib7 11547 2 / / SYM cord-005453-4057qib7 11547 3 m m NN cord-005453-4057qib7 11547 4 2 2 CD cord-005453-4057qib7 11548 1 + + CC cord-005453-4057qib7 11548 2 Melphalan Melphalan NNP cord-005453-4057qib7 11548 3 180 180 CD cord-005453-4057qib7 11548 4 mg mg NNP cord-005453-4057qib7 11548 5 / / SYM cord-005453-4057qib7 11548 6 m m NN cord-005453-4057qib7 11548 7 2 2 CD cord-005453-4057qib7 11548 8 . . . cord-005453-4057qib7 11549 1 At at IN cord-005453-4057qib7 11549 2 Day day NN cord-005453-4057qib7 11549 3 +90 +90 CD cord-005453-4057qib7 11549 4 after after IN cord-005453-4057qib7 11549 5 auto auto NN cord-005453-4057qib7 11549 6 - - HYPH cord-005453-4057qib7 11549 7 SCT SCT NNP cord-005453-4057qib7 11549 8 , , , cord-005453-4057qib7 11549 9 the the DT cord-005453-4057qib7 11549 10 patient patient NN cord-005453-4057qib7 11549 11 again again RB cord-005453-4057qib7 11549 12 demonstrated demonstrate VBD cord-005453-4057qib7 11549 13 progression progression NN cord-005453-4057qib7 11549 14 of of IN cord-005453-4057qib7 11549 15 the the DT cord-005453-4057qib7 11549 16 disease disease NN cord-005453-4057qib7 11549 17 : : : cord-005453-4057qib7 11550 1 PET PET NNP cord-005453-4057qib7 11550 2 / / SYM cord-005453-4057qib7 11550 3 CT CT NNP cord-005453-4057qib7 11550 4 - - HYPH cord-005453-4057qib7 11550 5 examination examination NN cord-005453-4057qib7 11550 6 showed show VBD cord-005453-4057qib7 11550 7 mediastinal mediastinal JJ cord-005453-4057qib7 11550 8 tumor tumor NN cord-005453-4057qib7 11550 9 mass mass NN cord-005453-4057qib7 11550 10 enlargement enlargement NN cord-005453-4057qib7 11550 11 with with IN cord-005453-4057qib7 11550 12 increased increase VBN cord-005453-4057qib7 11550 13 left left JJ cord-005453-4057qib7 11550 14 lung lung NN cord-005453-4057qib7 11550 15 nodule nodule NN cord-005453-4057qib7 11550 16 simultaneously simultaneously RB cord-005453-4057qib7 11550 17 to to IN cord-005453-4057qib7 11550 18 short short JJ cord-005453-4057qib7 11550 19 metabolic metabolic JJ cord-005453-4057qib7 11550 20 activity activity NN cord-005453-4057qib7 11550 21 . . . cord-005453-4057qib7 11551 1 Patient Patient NNP cord-005453-4057qib7 11551 2 was be VBD cord-005453-4057qib7 11551 3 under under IN cord-005453-4057qib7 11551 4 observation observation NN cord-005453-4057qib7 11551 5 . . . cord-005453-4057qib7 11552 1 At at IN cord-005453-4057qib7 11552 2 Day day NN cord-005453-4057qib7 11552 3 +140 +140 XX cord-005453-4057qib7 11552 4 the the DT cord-005453-4057qib7 11552 5 disease disease NN cord-005453-4057qib7 11552 6 had have VBD cord-005453-4057qib7 11552 7 relapsed relapse VBN cord-005453-4057qib7 11552 8 and and CC cord-005453-4057qib7 11552 9 progressed progress VBN cord-005453-4057qib7 11552 10 -examination -examination NN cord-005453-4057qib7 11552 11 by by IN cord-005453-4057qib7 11552 12 PET PET NNP cord-005453-4057qib7 11552 13 / / SYM cord-005453-4057qib7 11552 14 CT CT NNP cord-005453-4057qib7 11552 15 demonstrated demonstrate VBD cord-005453-4057qib7 11552 16 multifocal multifocal JJ cord-005453-4057qib7 11552 17 progressive progressive JJ cord-005453-4057qib7 11552 18 disease disease NN cord-005453-4057qib7 11552 19 with with IN cord-005453-4057qib7 11552 20 multiple multiple JJ cord-005453-4057qib7 11552 21 pulmonary pulmonary JJ cord-005453-4057qib7 11552 22 lesions lesion NNS cord-005453-4057qib7 11552 23 and and CC cord-005453-4057qib7 11552 24 increased increase VBN cord-005453-4057qib7 11552 25 metabolism metabolism NN cord-005453-4057qib7 11552 26 in in IN cord-005453-4057qib7 11552 27 comparison comparison NN cord-005453-4057qib7 11552 28 with with IN cord-005453-4057qib7 11552 29 the the DT cord-005453-4057qib7 11552 30 previous previous JJ cord-005453-4057qib7 11552 31 PET PET NNP cord-005453-4057qib7 11552 32 / / SYM cord-005453-4057qib7 11552 33 CT CT NNP cord-005453-4057qib7 11552 34 scan scan NN cord-005453-4057qib7 11552 35 . . . cord-005453-4057qib7 11553 1 In in IN cord-005453-4057qib7 11553 2 July July NNP cord-005453-4057qib7 11553 3 - - HYPH cord-005453-4057qib7 11553 4 October October NNP cord-005453-4057qib7 11553 5 2017 2017 CD cord-005453-4057qib7 11553 6 , , , cord-005453-4057qib7 11553 7 the the DT cord-005453-4057qib7 11553 8 patient patient NN cord-005453-4057qib7 11553 9 had have VBD cord-005453-4057qib7 11553 10 Salvage salvage NN cord-005453-4057qib7 11553 11 chemotherapy chemotherapy NN cord-005453-4057qib7 11553 12 with with IN cord-005453-4057qib7 11553 13 a a DT cord-005453-4057qib7 11553 14 combination combination NN cord-005453-4057qib7 11553 15 of of IN cord-005453-4057qib7 11553 16 Brentuximab Brentuximab NNP cord-005453-4057qib7 11553 17 vedotin vedotin NNP cord-005453-4057qib7 11553 18 ( ( -LRB- cord-005453-4057qib7 11553 19 BV BV NNP cord-005453-4057qib7 11553 20 ) ) -RRB- cord-005453-4057qib7 11553 21 ( ( -LRB- cord-005453-4057qib7 11553 22 BV BV NNP cord-005453-4057qib7 11553 23 DHAP DHAP NNP cord-005453-4057qib7 11553 24 ( ( -LRB- cord-005453-4057qib7 11553 25 dexamethasone dexamethasone NN cord-005453-4057qib7 11553 26 , , , cord-005453-4057qib7 11553 27 cytarabine cytarabine NN cord-005453-4057qib7 11553 28 , , , cord-005453-4057qib7 11553 29 cisplatin cisplatin NN cord-005453-4057qib7 11553 30 ) ) -RRB- cord-005453-4057qib7 11553 31 + + SYM cord-005453-4057qib7 11553 32 BV BV NNP cord-005453-4057qib7 11553 33 ( ( -LRB- cord-005453-4057qib7 11553 34 without without IN cord-005453-4057qib7 11553 35 chemotherapy chemotherapy NN cord-005453-4057qib7 11553 36 due due IN cord-005453-4057qib7 11553 37 to to IN cord-005453-4057qib7 11553 38 suspected suspect VBN cord-005453-4057qib7 11553 39 invasive invasive JJ cord-005453-4057qib7 11553 40 mycosis mycosi NNS cord-005453-4057qib7 11553 41 ) ) -RRB- cord-005453-4057qib7 11553 42 + + SYM cord-005453-4057qib7 11553 43 BV BV NNP cord-005453-4057qib7 11553 44 DHAP DHAP NNP cord-005453-4057qib7 11553 45 ) ) -RRB- cord-005453-4057qib7 11553 46 , , , cord-005453-4057qib7 11553 47 however however RB cord-005453-4057qib7 11553 48 , , , cord-005453-4057qib7 11553 49 only only JJ cord-005453-4057qib7 11553 50 partial partial JJ cord-005453-4057qib7 11553 51 PET pet NN cord-005453-4057qib7 11553 52 - - HYPH cord-005453-4057qib7 11553 53 positive positive JJ cord-005453-4057qib7 11553 54 remission remission NN cord-005453-4057qib7 11553 55 was be VBD cord-005453-4057qib7 11553 56 achieved achieve VBN cord-005453-4057qib7 11553 57 . . . cord-005453-4057qib7 11554 1 Because because IN cord-005453-4057qib7 11554 2 of of IN cord-005453-4057qib7 11554 3 many many JJ cord-005453-4057qib7 11554 4 times time NNS cord-005453-4057qib7 11554 5 relapsed relapsed JJ cord-005453-4057qib7 11554 6 and and CC cord-005453-4057qib7 11554 7 progressed progress VBD cord-005453-4057qib7 11554 8 disease disease NN cord-005453-4057qib7 11554 9 Pembrolizumab Pembrolizumab NNP cord-005453-4057qib7 11554 10 therapy therapy NN cord-005453-4057qib7 11554 11 was be VBD cord-005453-4057qib7 11554 12 started start VBN cord-005453-4057qib7 11554 13 in in IN cord-005453-4057qib7 11554 14 October October NNP cord-005453-4057qib7 11554 15 2017 2017 CD cord-005453-4057qib7 11555 1 : : : cord-005453-4057qib7 11555 2 2 2 CD cord-005453-4057qib7 11555 3 mg mg NNP cord-005453-4057qib7 11555 4 / / SYM cord-005453-4057qib7 11555 5 kg kg NNP cord-005453-4057qib7 11555 6 every every DT cord-005453-4057qib7 11555 7 three three CD cord-005453-4057qib7 11555 8 weeks week NNS cord-005453-4057qib7 11556 1 four four CD cord-005453-4057qib7 11556 2 cycles cycle NNS cord-005453-4057qib7 11556 3 totally totally RB cord-005453-4057qib7 11556 4 . . . cord-005453-4057qib7 11557 1 Toxic toxic JJ cord-005453-4057qib7 11557 2 effects effect NNS cord-005453-4057qib7 11557 3 and and CC cord-005453-4057qib7 11557 4 serious serious JJ cord-005453-4057qib7 11557 5 complications complication NNS cord-005453-4057qib7 11557 6 during during IN cord-005453-4057qib7 11557 7 and and CC cord-005453-4057qib7 11557 8 after after IN cord-005453-4057qib7 11557 9 therapy therapy NN cord-005453-4057qib7 11557 10 by by IN cord-005453-4057qib7 11557 11 Pembrolizumab Pembrolizumab NNP cord-005453-4057qib7 11557 12 were be VBD cord-005453-4057qib7 11557 13 not not RB cord-005453-4057qib7 11557 14 observed observe VBN cord-005453-4057qib7 11557 15 . . . cord-005453-4057qib7 11558 1 In in IN cord-005453-4057qib7 11558 2 February February NNP cord-005453-4057qib7 11558 3 2018 2018 CD cord-005453-4057qib7 11558 4 , , , cord-005453-4057qib7 11558 5 after after IN cord-005453-4057qib7 11558 6 Pembrolizumab Pembrolizumab NNP cord-005453-4057qib7 11558 7 # # $ cord-005453-4057qib7 11558 8 4 4 CD cord-005453-4057qib7 11558 9 , , , cord-005453-4057qib7 11558 10 the the DT cord-005453-4057qib7 11558 11 patient patient NN cord-005453-4057qib7 11558 12 showed show VBD cord-005453-4057qib7 11558 13 complete complete JJ cord-005453-4057qib7 11558 14 metabolic metabolic JJ cord-005453-4057qib7 11558 15 remission remission NN cord-005453-4057qib7 11558 16 of of IN cord-005453-4057qib7 11558 17 the the DT cord-005453-4057qib7 11558 18 disease disease NN cord-005453-4057qib7 11558 19 by by IN cord-005453-4057qib7 11558 20 control control NNP cord-005453-4057qib7 11558 21 PET PET NNP cord-005453-4057qib7 11558 22 - - HYPH cord-005453-4057qib7 11558 23 CT CT NNP cord-005453-4057qib7 11558 24 . . . cord-005453-4057qib7 11559 1 In in IN cord-005453-4057qib7 11559 2 April April NNP cord-005453-4057qib7 11559 3 2018 2018 CD cord-005453-4057qib7 11559 4 , , , cord-005453-4057qib7 11559 5 the the DT cord-005453-4057qib7 11559 6 patient patient NN cord-005453-4057qib7 11559 7 received receive VBD cord-005453-4057qib7 11559 8 haplo haplo NNP cord-005453-4057qib7 11559 9 - - HYPH cord-005453-4057qib7 11559 10 SCT SCT NNP cord-005453-4057qib7 11559 11 with with IN cord-005453-4057qib7 11559 12 post post JJ cord-005453-4057qib7 11559 13 - - JJ cord-005453-4057qib7 11559 14 transplant transplant JJ cord-005453-4057qib7 11559 15 HD hd NN cord-005453-4057qib7 11559 16 - - HYPH cord-005453-4057qib7 11559 17 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 11559 18 . . . cord-005453-4057qib7 11560 1 We -PRON- PRP cord-005453-4057qib7 11560 2 used use VBD cord-005453-4057qib7 11560 3 conditioning conditioning NN cord-005453-4057qib7 11560 4 modes mode NNS cord-005453-4057qib7 11560 5 with with IN cord-005453-4057qib7 11560 6 reduced reduce VBN cord-005453-4057qib7 11560 7 toxicity toxicity NN cord-005453-4057qib7 11560 8 ( ( -LRB- cord-005453-4057qib7 11561 1 Fludarabin Fludarabin NNP cord-005453-4057qib7 11561 2 150mg 150mg NNP cord-005453-4057qib7 11561 3 / / SYM cord-005453-4057qib7 11561 4 m m NN cord-005453-4057qib7 11561 5 2 2 CD cord-005453-4057qib7 11561 6 + + SYM cord-005453-4057qib7 11561 7 Treosulfan Treosulfan NNP cord-005453-4057qib7 11561 8 42g 42g NNS cord-005453-4057qib7 11561 9 / / SYM cord-005453-4057qib7 11561 10 m m CD cord-005453-4057qib7 11561 11 2 2 CD cord-005453-4057qib7 11561 12 ) ) -RRB- cord-005453-4057qib7 11561 13 , , , cord-005453-4057qib7 11561 14 high high JJ cord-005453-4057qib7 11561 15 doses dose NNS cord-005453-4057qib7 11561 16 of of IN cord-005453-4057qib7 11561 17 Cy Cy NNP cord-005453-4057qib7 11561 18 ( ( -LRB- cord-005453-4057qib7 11561 19 50 50 CD cord-005453-4057qib7 11561 20 mg mg NNP cord-005453-4057qib7 11561 21 / / SYM cord-005453-4057qib7 11561 22 kg kg NNP cord-005453-4057qib7 11561 23 ) ) -RRB- cord-005453-4057qib7 11561 24 on on IN cord-005453-4057qib7 11561 25 days day NNS cord-005453-4057qib7 11561 26 +3 +3 NNP cord-005453-4057qib7 11561 27 and and CC cord-005453-4057qib7 11561 28 +4 +4 NN cord-005453-4057qib7 11561 29 . . . cord-005453-4057qib7 11562 1 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 11562 2 and and CC cord-005453-4057qib7 11562 3 mycophenolate mycophenolate NNP cord-005453-4057qib7 11562 4 mofetil mofetil NNP cord-005453-4057qib7 11562 5 started start VBD cord-005453-4057qib7 11562 6 on on IN cord-005453-4057qib7 11562 7 day day NN cord-005453-4057qib7 11562 8 +5 +5 NFP cord-005453-4057qib7 11562 9 . . . cord-005453-4057qib7 11563 1 MMF MMF NNP cord-005453-4057qib7 11563 2 was be VBD cord-005453-4057qib7 11563 3 terminated terminate VBN cord-005453-4057qib7 11563 4 on on IN cord-005453-4057qib7 11563 5 day day NN cord-005453-4057qib7 11563 6 35 35 CD cord-005453-4057qib7 11563 7 , , , cord-005453-4057qib7 11563 8 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 11563 9 -on -on . cord-005453-4057qib7 11563 10 day day NN cord-005453-4057qib7 11563 11 180 180 CD cord-005453-4057qib7 11563 12 . . . cord-005453-4057qib7 11564 1 Patient Patient NNP cord-005453-4057qib7 11564 2 did do VBD cord-005453-4057qib7 11564 3 not not RB cord-005453-4057qib7 11564 4 have have VB cord-005453-4057qib7 11564 5 acute acute JJ cord-005453-4057qib7 11564 6 and and CC cord-005453-4057qib7 11564 7 chronic chronic JJ cord-005453-4057qib7 11564 8 GVHD GVHD NNP cord-005453-4057qib7 11564 9 . . . cord-005453-4057qib7 11565 1 Results result NNS cord-005453-4057qib7 11565 2 : : : cord-005453-4057qib7 11566 1 At at IN cord-005453-4057qib7 11566 2 the the DT cord-005453-4057qib7 11566 3 moment moment NN cord-005453-4057qib7 11566 4 the the DT cord-005453-4057qib7 11566 5 patient patient NN cord-005453-4057qib7 11566 6 is be VBZ cord-005453-4057qib7 11566 7 alive alive JJ cord-005453-4057qib7 11566 8 and and CC cord-005453-4057qib7 11566 9 still still RB cord-005453-4057qib7 11566 10 in in IN cord-005453-4057qib7 11566 11 PET pet NN cord-005453-4057qib7 11566 12 - - HYPH cord-005453-4057qib7 11566 13 negative negative JJ cord-005453-4057qib7 11566 14 CR cr NN cord-005453-4057qib7 11566 15 with with IN cord-005453-4057qib7 11566 16 duration duration NN cord-005453-4057qib7 11566 17 more more JJR cord-005453-4057qib7 11566 18 than than IN cord-005453-4057qib7 11566 19 9 9 CD cord-005453-4057qib7 11566 20 mo mo NN cord-005453-4057qib7 11566 21 . . . cord-005453-4057qib7 11567 1 Conclusions conclusion NNS cord-005453-4057qib7 11567 2 : : : cord-005453-4057qib7 11568 1 Pembrolizumab Pembrolizumab NNP cord-005453-4057qib7 11568 2 has have VBZ cord-005453-4057qib7 11568 3 demonstrated demonstrate VBN cord-005453-4057qib7 11568 4 high high JJ cord-005453-4057qib7 11568 5 activity activity NN cord-005453-4057qib7 11568 6 against against IN cord-005453-4057qib7 11568 7 resistant resistant JJ cord-005453-4057qib7 11568 8 HD hd NN cord-005453-4057qib7 11568 9 even even RB cord-005453-4057qib7 11568 10 after after IN cord-005453-4057qib7 11568 11 post post JJ cord-005453-4057qib7 11568 12 - - JJ cord-005453-4057qib7 11568 13 auto auto JJ cord-005453-4057qib7 11568 14 - - HYPH cord-005453-4057qib7 11568 15 SCT sct NN cord-005453-4057qib7 11568 16 progression progression NN cord-005453-4057qib7 11568 17 with with IN cord-005453-4057qib7 11568 18 good good JJ cord-005453-4057qib7 11568 19 tolerability tolerability NN cord-005453-4057qib7 11568 20 for for IN cord-005453-4057qib7 11568 21 the the DT cord-005453-4057qib7 11568 22 sick sick JJ cord-005453-4057qib7 11568 23 child child NN cord-005453-4057qib7 11568 24 . . . cord-005453-4057qib7 11569 1 Disclosure disclosure NN cord-005453-4057qib7 11569 2 : : : cord-005453-4057qib7 11569 3 Nothing nothing NN cord-005453-4057qib7 11569 4 to to TO cord-005453-4057qib7 11569 5 declare declare VB cord-005453-4057qib7 11569 6 P510 P510 NNP cord-005453-4057qib7 11569 7 High High NNP cord-005453-4057qib7 11569 8 dose dose NN cord-005453-4057qib7 11569 9 chemotherapy chemotherapy NN cord-005453-4057qib7 11569 10 followed follow VBN cord-005453-4057qib7 11569 11 by by IN cord-005453-4057qib7 11569 12 autolougous autolougous JJ cord-005453-4057qib7 11569 13 peripheral peripheral JJ cord-005453-4057qib7 11569 14 blood blood NN cord-005453-4057qib7 11569 15 stem stem NN cord-005453-4057qib7 11569 16 cell cell NN cord-005453-4057qib7 11569 17 transplantation transplantation NN cord-005453-4057qib7 11569 18 ( ( -LRB- cord-005453-4057qib7 11569 19 ASCT ASCT NNP cord-005453-4057qib7 11569 20 ) ) -RRB- cord-005453-4057qib7 11569 21 in in IN cord-005453-4057qib7 11569 22 diffuse diffuse JJ cord-005453-4057qib7 11569 23 large large JJ cord-005453-4057qib7 11569 24 B b NN cord-005453-4057qib7 11569 25 cell cell NN cord-005453-4057qib7 11569 26 lymphoma lymphoma NN cord-005453-4057qib7 11569 27 ( ( -LRB- cord-005453-4057qib7 11569 28 DLBCL DLBCL NNP cord-005453-4057qib7 11569 29 ) ) -RRB- cord-005453-4057qib7 11570 1 Median median JJ cord-005453-4057qib7 11570 2 age age NN cord-005453-4057qib7 11570 3 is be VBZ cord-005453-4057qib7 11570 4 38,9 38,9 CD cord-005453-4057qib7 11570 5 years year NNS cord-005453-4057qib7 11570 6 ( ( -LRB- cord-005453-4057qib7 11570 7 14 14 CD cord-005453-4057qib7 11570 8 to to TO cord-005453-4057qib7 11570 9 67 67 CD cord-005453-4057qib7 11570 10 ) ) -RRB- cord-005453-4057qib7 11570 11 and and CC cord-005453-4057qib7 11570 12 sex sex NN cord-005453-4057qib7 11570 13 ratio ratio NN cord-005453-4057qib7 11570 14 ( ( -LRB- cord-005453-4057qib7 11570 15 M M NNP cord-005453-4057qib7 11570 16 / / SYM cord-005453-4057qib7 11570 17 F F NNP cord-005453-4057qib7 11570 18 ) ) -RRB- cord-005453-4057qib7 11570 19 1.14 1.14 CD cord-005453-4057qib7 11570 20 ; ; : cord-005453-4057qib7 11570 21 Ann Ann NNP cord-005453-4057qib7 11570 22 Arbor Arbor NNP cord-005453-4057qib7 11570 23 stage stage NN cord-005453-4057qib7 11570 24 III III NNP cord-005453-4057qib7 11570 25 - - HYPH cord-005453-4057qib7 11570 26 IV IV NNP cord-005453-4057qib7 11570 27 : : : cord-005453-4057qib7 11570 28 104 104 CD cord-005453-4057qib7 11570 29 pts pt NNS cord-005453-4057qib7 11570 30 . . . cord-005453-4057qib7 11571 1 Before before IN cord-005453-4057qib7 11571 2 HDT HDT NNP cord-005453-4057qib7 11571 3 induction induction NN cord-005453-4057qib7 11571 4 chemotherapy chemotherapy NN cord-005453-4057qib7 11571 5 ( ( -LRB- cord-005453-4057qib7 11571 6 CHOP chop NN cord-005453-4057qib7 11571 7 , , , cord-005453-4057qib7 11571 8 C2H2OPA C2H2OPA NNP cord-005453-4057qib7 11571 9 ) ) -RRB- cord-005453-4057qib7 11571 10 was be VBD cord-005453-4057qib7 11571 11 instituted institute VBN cord-005453-4057qib7 11571 12 and and CC cord-005453-4057qib7 11571 13 associated associate VBN cord-005453-4057qib7 11571 14 with with IN cord-005453-4057qib7 11571 15 Rituximab Rituximab NNP cord-005453-4057qib7 11571 16 in in IN cord-005453-4057qib7 11571 17 100 100 CD cord-005453-4057qib7 11571 18 pts pt NNS cord-005453-4057qib7 11571 19 ( ( -LRB- cord-005453-4057qib7 11571 20 66,6 66,6 CD cord-005453-4057qib7 11571 21 % % NN cord-005453-4057qib7 11571 22 ) ) -RRB- cord-005453-4057qib7 11571 23 , , , cord-005453-4057qib7 11571 24 49 49 CD cord-005453-4057qib7 11571 25 pts pt NNS cord-005453-4057qib7 11571 26 ( ( -LRB- cord-005453-4057qib7 11571 27 32,7 32,7 CD cord-005453-4057qib7 11571 28 % % NN cord-005453-4057qib7 11571 29 ) ) -RRB- cord-005453-4057qib7 11571 30 received receive VBD cord-005453-4057qib7 11571 31 more more JJR cord-005453-4057qib7 11571 32 than than IN cord-005453-4057qib7 11571 33 2 2 CD cord-005453-4057qib7 11571 34 treatment treatment NN cord-005453-4057qib7 11571 35 lines line NNS cord-005453-4057qib7 11571 36 and and CC cord-005453-4057qib7 11571 37 16 16 CD cord-005453-4057qib7 11571 38 pts pt NNS cord-005453-4057qib7 11571 39 ( ( -LRB- cord-005453-4057qib7 11571 40 10,7 10,7 CD cord-005453-4057qib7 11571 41 % % NN cord-005453-4057qib7 11571 42 ) ) -RRB- cord-005453-4057qib7 11571 43 received receive VBD cord-005453-4057qib7 11571 44 complementary complementary JJ cord-005453-4057qib7 11571 45 radiotherapy radiotherapy NN cord-005453-4057qib7 11571 46 . . . cord-005453-4057qib7 11572 1 Transplant transplant NN cord-005453-4057qib7 11572 2 disease disease NN cord-005453-4057qib7 11572 3 status status NN cord-005453-4057qib7 11572 4 before before IN cord-005453-4057qib7 11572 5 HDT HDT NNP cord-005453-4057qib7 11572 6 was be VBD cord-005453-4057qib7 11572 7 complete complete JJ cord-005453-4057qib7 11572 8 remission remission NN cord-005453-4057qib7 11572 9 ( ( -LRB- cord-005453-4057qib7 11572 10 CR CR NNP cord-005453-4057qib7 11572 11 ) ) -RRB- cord-005453-4057qib7 11572 12 in in IN cord-005453-4057qib7 11572 13 93 93 CD cord-005453-4057qib7 11572 14 pts pt NNS cord-005453-4057qib7 11572 15 , , , cord-005453-4057qib7 11572 16 partial partial JJ cord-005453-4057qib7 11572 17 remission remission NN cord-005453-4057qib7 11572 18 in in IN cord-005453-4057qib7 11572 19 55 55 CD cord-005453-4057qib7 11572 20 pts pt NNS cord-005453-4057qib7 11572 21 ( ( -LRB- cord-005453-4057qib7 11572 22 RP RP NNP cord-005453-4057qib7 11572 23 ) ) -RRB- cord-005453-4057qib7 11572 24 and and CC cord-005453-4057qib7 11572 25 disease disease NN cord-005453-4057qib7 11572 26 progression progression NN cord-005453-4057qib7 11572 27 in in IN cord-005453-4057qib7 11572 28 2 2 CD cord-005453-4057qib7 11572 29 pts pt NNS cord-005453-4057qib7 11572 30 . . . cord-005453-4057qib7 11573 1 The the DT cord-005453-4057qib7 11573 2 delay delay NN cord-005453-4057qib7 11573 3 from from IN cord-005453-4057qib7 11573 4 diagnosis diagnosis NN cord-005453-4057qib7 11573 5 to to IN cord-005453-4057qib7 11573 6 HDT HDT NNP cord-005453-4057qib7 11573 7 is be VBZ cord-005453-4057qib7 11573 8 11,7 11,7 CD cord-005453-4057qib7 11573 9 months month NNS cord-005453-4057qib7 11573 10 ( ( -LRB- cord-005453-4057qib7 11573 11 4 4 CD cord-005453-4057qib7 11573 12 - - SYM cord-005453-4057qib7 11573 13 103 103 CD cord-005453-4057qib7 11573 14 ) ) -RRB- cord-005453-4057qib7 11573 15 . . . cord-005453-4057qib7 11574 1 The the DT cord-005453-4057qib7 11574 2 HDT HDT NNP cord-005453-4057qib7 11574 3 protocols protocol NNS cord-005453-4057qib7 11574 4 used use VBN cord-005453-4057qib7 11574 5 are be VBP cord-005453-4057qib7 11574 6 : : : cord-005453-4057qib7 11574 7 Tutshka tutshka NN cord-005453-4057qib7 11574 8 : : : cord-005453-4057qib7 11574 9 87 87 CD cord-005453-4057qib7 11574 10 pts pt NNS cord-005453-4057qib7 11574 11 , , , cord-005453-4057qib7 11574 12 Tutshka+VP16 Tutshka+VP16 NNP cord-005453-4057qib7 11574 13 : : : cord-005453-4057qib7 11574 14 42 42 CD cord-005453-4057qib7 11574 15 pts pt NNS cord-005453-4057qib7 11574 16 , , , cord-005453-4057qib7 11574 17 BAM BAM NNP cord-005453-4057qib7 11574 18 12 12 CD cord-005453-4057qib7 11574 19 ( ( -LRB- cord-005453-4057qib7 11574 20 Busulfan Busulfan NNP cord-005453-4057qib7 11574 21 + + CC cord-005453-4057qib7 11574 22 Cytarabine+Melphalan cytarabine+melphalan NN cord-005453-4057qib7 11574 23 ) ) -RRB- cord-005453-4057qib7 11575 1 : : : cord-005453-4057qib7 11575 2 16 16 CD cord-005453-4057qib7 11575 3 pts pt NNS cord-005453-4057qib7 11575 4 et et FW cord-005453-4057qib7 11575 5 BEAM beam NN cord-005453-4057qib7 11575 6 : : : cord-005453-4057qib7 11575 7 5 5 CD cord-005453-4057qib7 11575 8 pts pt NNS cord-005453-4057qib7 11575 9 . . . cord-005453-4057qib7 11576 1 All all DT cord-005453-4057qib7 11576 2 pts pt NNS cord-005453-4057qib7 11576 3 received receive VBD cord-005453-4057qib7 11576 4 , , , cord-005453-4057qib7 11576 5 after after IN cord-005453-4057qib7 11576 6 thawing thawing NN cord-005453-4057qib7 11576 7 , , , cord-005453-4057qib7 11576 8 mobilized mobilize VBD cord-005453-4057qib7 11576 9 PBSC PBSC NNP cord-005453-4057qib7 11576 10 obtained obtain VBN cord-005453-4057qib7 11576 11 by by IN cord-005453-4057qib7 11576 12 G G NNP cord-005453-4057qib7 11576 13 - - HYPH cord-005453-4057qib7 11576 14 CSF csf NN cord-005453-4057qib7 11576 15 mobilization mobilization NN cord-005453-4057qib7 11576 16 ( ( -LRB- cord-005453-4057qib7 11576 17 15μg 15μg NNP cord-005453-4057qib7 11576 18 / / SYM cord-005453-4057qib7 11576 19 Kg Kg NNP cord-005453-4057qib7 11576 20 / / SYM cord-005453-4057qib7 11576 21 d d NN cord-005453-4057qib7 11576 22 , , , cord-005453-4057qib7 11576 23 5 5 CD cord-005453-4057qib7 11576 24 days day NNS cord-005453-4057qib7 11576 25 ) ) -RRB- cord-005453-4057qib7 11576 26 alone alone RB cord-005453-4057qib7 11576 27 and and CC cord-005453-4057qib7 11576 28 froze freeze VBD cord-005453-4057qib7 11576 29 in in IN cord-005453-4057qib7 11576 30 liquid liquid JJ cord-005453-4057qib7 11576 31 nitrogen nitrogen NN cord-005453-4057qib7 11576 32 . . . cord-005453-4057qib7 11577 1 The the DT cord-005453-4057qib7 11577 2 median median JJ cord-005453-4057qib7 11577 3 rate rate NN cord-005453-4057qib7 11577 4 CD34 CD34 NNP cord-005453-4057qib7 11578 1 + + CC cord-005453-4057qib7 11578 2 cells cell NNS cord-005453-4057qib7 11578 3 infused infuse VBN cord-005453-4057qib7 11578 4 is be VBZ cord-005453-4057qib7 11578 5 3,6 3,6 CD cord-005453-4057qib7 11578 6 x x SYM cord-005453-4057qib7 11578 7 10 10 CD cord-005453-4057qib7 11578 8 6 6 CD cord-005453-4057qib7 11579 1 /Kg /Kg . cord-005453-4057qib7 11580 1 ( ( -LRB- cord-005453-4057qib7 11580 2 0 0 CD cord-005453-4057qib7 11580 3 . . . cord-005453-4057qib7 11580 4 87 87 CD cord-005453-4057qib7 11580 5 - - SYM cord-005453-4057qib7 11580 6 17.36 17.36 CD cord-005453-4057qib7 11580 7 ) ) -RRB- cord-005453-4057qib7 11580 8 . . . cord-005453-4057qib7 11581 1 The the DT cord-005453-4057qib7 11581 2 median median JJ cord-005453-4057qib7 11581 3 follow follow NN cord-005453-4057qib7 11581 4 - - HYPH cord-005453-4057qib7 11581 5 up up NN cord-005453-4057qib7 11581 6 at at IN cord-005453-4057qib7 11581 7 12/31/2017 12/31/2017 CD cord-005453-4057qib7 11581 8 is be VBZ cord-005453-4057qib7 11581 9 67 67 CD cord-005453-4057qib7 11581 10 months month NNS cord-005453-4057qib7 11581 11 . . . cord-005453-4057qib7 11582 1 Results result NNS cord-005453-4057qib7 11582 2 : : : cord-005453-4057qib7 11582 3 the the DT cord-005453-4057qib7 11582 4 median median JJ cord-005453-4057qib7 11582 5 time time NN cord-005453-4057qib7 11582 6 to to TO cord-005453-4057qib7 11582 7 graft graft VB cord-005453-4057qib7 11582 8 ( ( -LRB- cord-005453-4057qib7 11582 9 PNC PNC NNP cord-005453-4057qib7 11582 10 > > XX cord-005453-4057qib7 11582 11 0.5 0.5 CD cord-005453-4057qib7 11582 12 x x SYM cord-005453-4057qib7 11582 13 10 10 CD cord-005453-4057qib7 11582 14 9 9 CD cord-005453-4057qib7 11582 15 /l /l NN cord-005453-4057qib7 11582 16 ) ) -RRB- cord-005453-4057qib7 11582 17 was be VBD cord-005453-4057qib7 11582 18 13 13 CD cord-005453-4057qib7 11582 19 days day NNS cord-005453-4057qib7 11582 20 ( ( -LRB- cord-005453-4057qib7 11582 21 9 9 CD cord-005453-4057qib7 11582 22 - - SYM cord-005453-4057qib7 11582 23 18 18 CD cord-005453-4057qib7 11582 24 ) ) -RRB- cord-005453-4057qib7 11582 25 . . . cord-005453-4057qib7 11583 1 Ten ten CD cord-005453-4057qib7 11583 2 early early JJ cord-005453-4057qib7 11583 3 deaths death NNS cord-005453-4057qib7 11583 4 were be VBD cord-005453-4057qib7 11583 5 observed observe VBN cord-005453-4057qib7 11583 6 including include VBG cord-005453-4057qib7 11583 7 8 8 CD cord-005453-4057qib7 11583 8 infection infection NN cord-005453-4057qib7 11583 9 ( ( -LRB- cord-005453-4057qib7 11583 10 TRM TRM NNP cord-005453-4057qib7 11583 11 : : : cord-005453-4057qib7 11583 12 6,6 6,6 CD cord-005453-4057qib7 11583 13 % % NN cord-005453-4057qib7 11583 14 ) ) -RRB- cord-005453-4057qib7 11583 15 and and CC cord-005453-4057qib7 11583 16 3 3 CD cord-005453-4057qib7 11583 17 in in IN cord-005453-4057qib7 11583 18 disease disease NN cord-005453-4057qib7 11583 19 progression progression NN cord-005453-4057qib7 11583 20 at at IN cord-005453-4057qib7 11583 21 3 3 CD cord-005453-4057qib7 11583 22 months month NNS cord-005453-4057qib7 11583 23 . . . cord-005453-4057qib7 11584 1 After after IN cord-005453-4057qib7 11584 2 3 3 CD cord-005453-4057qib7 11584 3 months month NNS cord-005453-4057qib7 11584 4 of of IN cord-005453-4057qib7 11584 5 HDT HDT NNP cord-005453-4057qib7 11584 6 137 137 CD cord-005453-4057qib7 11584 7 pts pt NNS cord-005453-4057qib7 11584 8 are be VBP cord-005453-4057qib7 11584 9 assessable assessable JJ cord-005453-4057qib7 11584 10 including include VBG cord-005453-4057qib7 11584 11 128 128 CD cord-005453-4057qib7 11584 12 pts pt NNS cord-005453-4057qib7 11584 13 in in IN cord-005453-4057qib7 11584 14 CR CR NNP cord-005453-4057qib7 11584 15 ( ( -LRB- cord-005453-4057qib7 11584 16 93,4 93,4 CD cord-005453-4057qib7 11584 17 % % NN cord-005453-4057qib7 11584 18 ) ) -RRB- cord-005453-4057qib7 11584 19 and and CC cord-005453-4057qib7 11584 20 9 9 CD cord-005453-4057qib7 11584 21 pts pt NNS cord-005453-4057qib7 11584 22 in in IN cord-005453-4057qib7 11584 23 PR PR NNP cord-005453-4057qib7 11584 24 ( ( -LRB- cord-005453-4057qib7 11584 25 6,6 6,6 CD cord-005453-4057qib7 11584 26 % % NN cord-005453-4057qib7 11584 27 ) ) -RRB- cord-005453-4057qib7 11584 28 . . . cord-005453-4057qib7 11585 1 Relapse relapse NN cord-005453-4057qib7 11585 2 was be VBD cord-005453-4057qib7 11585 3 observed observe VBN cord-005453-4057qib7 11585 4 in in IN cord-005453-4057qib7 11585 5 31 31 CD cord-005453-4057qib7 11585 6 pts pt NNS cord-005453-4057qib7 11585 7 ( ( -LRB- cord-005453-4057qib7 11585 8 22.6 22.6 CD cord-005453-4057qib7 11585 9 % % NN cord-005453-4057qib7 11585 10 ) ) -RRB- cord-005453-4057qib7 11585 11 and and CC cord-005453-4057qib7 11585 12 it -PRON- PRP cord-005453-4057qib7 11585 13 was be VBD cord-005453-4057qib7 11585 14 earlier early JJR cord-005453-4057qib7 11585 15 relapse relapse NN cord-005453-4057qib7 11585 16 in in IN cord-005453-4057qib7 11585 17 a a DT cord-005453-4057qib7 11585 18 period period NN cord-005453-4057qib7 11585 19 of of IN cord-005453-4057qib7 11585 20 24 24 CD cord-005453-4057qib7 11585 21 months month NNS cord-005453-4057qib7 11585 22 in in IN cord-005453-4057qib7 11585 23 15 15 CD cord-005453-4057qib7 11585 24 pts pt NNS cord-005453-4057qib7 11585 25 ( ( -LRB- cord-005453-4057qib7 11585 26 48 48 CD cord-005453-4057qib7 11585 27 % % NN cord-005453-4057qib7 11585 28 ) ) -RRB- cord-005453-4057qib7 11585 29 . . . cord-005453-4057qib7 11586 1 Deaths death NNS cord-005453-4057qib7 11586 2 were be VBD cord-005453-4057qib7 11586 3 among among IN cord-005453-4057qib7 11586 4 39/150 39/150 CD cord-005453-4057qib7 11586 5 pts pt NNS cord-005453-4057qib7 11586 6 ( ( -LRB- cord-005453-4057qib7 11586 7 26 26 CD cord-005453-4057qib7 11586 8 % % NN cord-005453-4057qib7 11586 9 ) ) -RRB- cord-005453-4057qib7 11586 10 . . . cord-005453-4057qib7 11587 1 Persistent persistent JJ cord-005453-4057qib7 11587 2 CR CR NNP cord-005453-4057qib7 11587 3 was be VBD cord-005453-4057qib7 11587 4 achieved achieve VBN cord-005453-4057qib7 11587 5 in in IN cord-005453-4057qib7 11587 6 112/137 112/137 CD cord-005453-4057qib7 11587 7 pts pt NNS cord-005453-4057qib7 11587 8 ( ( -LRB- cord-005453-4057qib7 11587 9 81,8 81,8 CD cord-005453-4057qib7 11587 10 % % NN cord-005453-4057qib7 11587 11 ) ) -RRB- cord-005453-4057qib7 11587 12 including include VBG cord-005453-4057qib7 11587 13 23/30 23/30 CD cord-005453-4057qib7 11587 14 ( ( -LRB- cord-005453-4057qib7 11587 15 76,6 76,6 CD cord-005453-4057qib7 11587 16 % % NN cord-005453-4057qib7 11587 17 ) ) -RRB- cord-005453-4057qib7 11587 18 MLCL MLCL NNP cord-005453-4057qib7 11587 19 and and CC cord-005453-4057qib7 11587 20 89/107 89/107 CD cord-005453-4057qib7 11587 21 ( ( -LRB- cord-005453-4057qib7 11587 22 83,1 83,1 CD cord-005453-4057qib7 11587 23 % % NN cord-005453-4057qib7 11587 24 ) ) -RRB- cord-005453-4057qib7 11588 1 others other NNS cord-005453-4057qib7 11588 2 DLBCL dlbcl VBP cord-005453-4057qib7 11588 3 . . . cord-005453-4057qib7 11589 1 The the DT cord-005453-4057qib7 11589 2 overall overall JJ cord-005453-4057qib7 11589 3 survival survival NN cord-005453-4057qib7 11589 4 ( ( -LRB- cord-005453-4057qib7 11589 5 OS OS NNP cord-005453-4057qib7 11589 6 ) ) -RRB- cord-005453-4057qib7 11589 7 and and CC cord-005453-4057qib7 11589 8 event event VB cord-005453-4057qib7 11589 9 free free JJ cord-005453-4057qib7 11589 10 survival survival NN cord-005453-4057qib7 11589 11 ( ( -LRB- cord-005453-4057qib7 11589 12 EFS EFS NNP cord-005453-4057qib7 11589 13 ) ) -RRB- cord-005453-4057qib7 11589 14 at at IN cord-005453-4057qib7 11589 15 10 10 CD cord-005453-4057qib7 11589 16 years year NNS cord-005453-4057qib7 11589 17 are be VBP cord-005453-4057qib7 11589 18 respectively respectively RB cord-005453-4057qib7 11589 19 68 68 CD cord-005453-4057qib7 11589 20 % % NN cord-005453-4057qib7 11589 21 and and CC cord-005453-4057qib7 11589 22 64 64 CD cord-005453-4057qib7 11589 23 % % NN cord-005453-4057qib7 11589 24 . . . cord-005453-4057qib7 11590 1 The the DT cord-005453-4057qib7 11590 2 OS OS NNP cord-005453-4057qib7 11590 3 and and CC cord-005453-4057qib7 11590 4 EFS EFS NNP cord-005453-4057qib7 11590 5 are be VBP cord-005453-4057qib7 11590 6 better well JJR cord-005453-4057qib7 11590 7 in in IN cord-005453-4057qib7 11590 8 patients patient NNS cord-005453-4057qib7 11590 9 who who WP cord-005453-4057qib7 11590 10 received receive VBD cord-005453-4057qib7 11590 11 Rituximab Rituximab NNP cord-005453-4057qib7 11590 12 in in IN cord-005453-4057qib7 11590 13 initial initial JJ cord-005453-4057qib7 11590 14 therapy therapy NN cord-005453-4057qib7 11590 15 : : : cord-005453-4057qib7 11590 16 OS OS NNP cord-005453-4057qib7 11590 17 ( ( -LRB- cord-005453-4057qib7 11590 18 79 79 CD cord-005453-4057qib7 11590 19 % % NN cord-005453-4057qib7 11590 20 vs vs IN cord-005453-4057qib7 11590 21 54 54 CD cord-005453-4057qib7 11590 22 % % NN cord-005453-4057qib7 11590 23 ; ; : cord-005453-4057qib7 11590 24 p p NN cord-005453-4057qib7 11590 25 < < XX cord-005453-4057qib7 11590 26 0,001 0,001 CD cord-005453-4057qib7 11590 27 ) ) -RRB- cord-005453-4057qib7 11590 28 et et FW cord-005453-4057qib7 11590 29 EFS EFS NNP cord-005453-4057qib7 11590 30 ( ( -LRB- cord-005453-4057qib7 11590 31 79 79 CD cord-005453-4057qib7 11590 32 % % NN cord-005453-4057qib7 11590 33 vs vs IN cord-005453-4057qib7 11590 34 46 46 CD cord-005453-4057qib7 11590 35 % % NN cord-005453-4057qib7 11590 36 ; ; . cord-005453-4057qib7 11591 1 p p LS cord-005453-4057qib7 11591 2 < < XX cord-005453-4057qib7 11591 3 0,001 0,001 CD cord-005453-4057qib7 11591 4 ) ) -RRB- cord-005453-4057qib7 11591 5 . . . cord-005453-4057qib7 11592 1 Herein herein RB cord-005453-4057qib7 11592 2 , , , cord-005453-4057qib7 11592 3 we -PRON- PRP cord-005453-4057qib7 11592 4 present present VBP cord-005453-4057qib7 11592 5 one one CD cord-005453-4057qib7 11592 6 patient patient NN cord-005453-4057qib7 11592 7 with with IN cord-005453-4057qib7 11592 8 refractory refractory JJ cord-005453-4057qib7 11592 9 MCL MCL NNP cord-005453-4057qib7 11592 10 , , , cord-005453-4057qib7 11592 11 who who WP cord-005453-4057qib7 11592 12 were be VBD cord-005453-4057qib7 11592 13 insensitive insensitive JJ cord-005453-4057qib7 11592 14 to to IN cord-005453-4057qib7 11592 15 chemotherapy chemotherapy NN cord-005453-4057qib7 11592 16 and and CC cord-005453-4057qib7 11592 17 then then RB cord-005453-4057qib7 11592 18 experienced experience VBD cord-005453-4057qib7 11592 19 a a DT cord-005453-4057qib7 11592 20 dramatic dramatic JJ cord-005453-4057qib7 11592 21 improvement improvement NN cord-005453-4057qib7 11592 22 with with IN cord-005453-4057qib7 11592 23 ibrutinib ibrutinib NNP cord-005453-4057qib7 11592 24 mono mono NN cord-005453-4057qib7 11592 25 - - HYPH cord-005453-4057qib7 11592 26 therapy therapy NN cord-005453-4057qib7 11592 27 but but CC cord-005453-4057qib7 11592 28 later later RB cord-005453-4057qib7 11592 29 developed develop VBD cord-005453-4057qib7 11592 30 ibrutinib ibrutinib NN cord-005453-4057qib7 11592 31 resistance resistance NN cord-005453-4057qib7 11592 32 , , , cord-005453-4057qib7 11592 33 ultimately ultimately RB cord-005453-4057qib7 11592 34 resulting result VBG cord-005453-4057qib7 11592 35 in in IN cord-005453-4057qib7 11592 36 the the DT cord-005453-4057qib7 11592 37 deterioration deterioration NN cord-005453-4057qib7 11592 38 of of IN cord-005453-4057qib7 11592 39 disease disease NN cord-005453-4057qib7 11592 40 and and CC cord-005453-4057qib7 11592 41 death death NN cord-005453-4057qib7 11592 42 . . . cord-005453-4057qib7 11593 1 Methods method NNS cord-005453-4057qib7 11593 2 : : : cord-005453-4057qib7 11593 3 We -PRON- PRP cord-005453-4057qib7 11593 4 give give VBP cord-005453-4057qib7 11593 5 the the DT cord-005453-4057qib7 11593 6 patient patient NN cord-005453-4057qib7 11593 7 several several JJ cord-005453-4057qib7 11593 8 examinations examination NNS cord-005453-4057qib7 11593 9 including include VBG cord-005453-4057qib7 11593 10 Ultrasound ultrasound NN cord-005453-4057qib7 11593 11 , , , cord-005453-4057qib7 11593 12 bone bone NN cord-005453-4057qib7 11593 13 marrow marrow NN cord-005453-4057qib7 11593 14 biopsy biopsy NN cord-005453-4057qib7 11593 15 , , , cord-005453-4057qib7 11593 16 lymph lymph NN cord-005453-4057qib7 11593 17 node node NN cord-005453-4057qib7 11593 18 biopsy biopsy NN cord-005453-4057qib7 11593 19 , , , cord-005453-4057qib7 11593 20 Exome Exome NNP cord-005453-4057qib7 11593 21 Sequencing Sequencing NNP cord-005453-4057qib7 11593 22 , , , cord-005453-4057qib7 11593 23 Sanger Sanger NNP cord-005453-4057qib7 11593 24 sequencing sequencing NN cord-005453-4057qib7 11593 25 , , , cord-005453-4057qib7 11593 26 and and CC cord-005453-4057qib7 11593 27 so so RB cord-005453-4057qib7 11593 28 on on RB cord-005453-4057qib7 11593 29 . . . cord-005453-4057qib7 11594 1 For for IN cord-005453-4057qib7 11594 2 the the DT cord-005453-4057qib7 11594 3 treatment treatment NN cord-005453-4057qib7 11594 4 of of IN cord-005453-4057qib7 11594 5 lymphoma lymphoma NN cord-005453-4057qib7 11594 6 , , , cord-005453-4057qib7 11594 7 the the DT cord-005453-4057qib7 11594 8 patient patient NN cord-005453-4057qib7 11594 9 received receive VBD cord-005453-4057qib7 11594 10 chemotherapy chemotherapy NN cord-005453-4057qib7 11594 11 , , , cord-005453-4057qib7 11594 12 including include VBG cord-005453-4057qib7 11594 13 1 1 CD cord-005453-4057qib7 11594 14 course course NN cord-005453-4057qib7 11594 15 of of IN cord-005453-4057qib7 11594 16 CHOP(cyclophosphamide CHOP(cyclophosphamide NNP cord-005453-4057qib7 11594 17 1.3 1.3 CD cord-005453-4057qib7 11594 18 g g NN cord-005453-4057qib7 11594 19 day day NN cord-005453-4057qib7 11594 20 1 1 CD cord-005453-4057qib7 11594 21 , , , cord-005453-4057qib7 11595 1 doxorubicin doxorubicin NN cord-005453-4057qib7 11595 2 40 40 CD cord-005453-4057qib7 11595 3 mg mg NNP cord-005453-4057qib7 11595 4 day day NN cord-005453-4057qib7 11595 5 1,Vinorelbine 1,vinorelbine CD cord-005453-4057qib7 11595 6 40 40 CD cord-005453-4057qib7 11595 7 mg mg NNP cord-005453-4057qib7 11595 8 day day NN cord-005453-4057qib7 11595 9 1 1 CD cord-005453-4057qib7 11595 10 , , , cord-005453-4057qib7 11595 11 and and CC cord-005453-4057qib7 11595 12 dexamethasone dexamethasone NN cord-005453-4057qib7 11595 13 15 15 CD cord-005453-4057qib7 11595 14 mg mg NN cord-005453-4057qib7 11595 15 from from IN cord-005453-4057qib7 11595 16 day day NN cord-005453-4057qib7 11595 17 1 1 CD cord-005453-4057qib7 11595 18 to to IN cord-005453-4057qib7 11595 19 5 5 CD cord-005453-4057qib7 11595 20 ) ) -RRB- cord-005453-4057qib7 11595 21 and and CC cord-005453-4057qib7 11595 22 1 1 CD cord-005453-4057qib7 11595 23 course course NN cord-005453-4057qib7 11595 24 of of IN cord-005453-4057qib7 11595 25 R r NN cord-005453-4057qib7 11595 26 - - HYPH cord-005453-4057qib7 11595 27 DHAP DHAP NNP cord-005453-4057qib7 11595 28 ( ( -LRB- cord-005453-4057qib7 11595 29 rituximab rituximab RB cord-005453-4057qib7 11595 30 600 600 CD cord-005453-4057qib7 11595 31 mg mg NNS cord-005453-4057qib7 11595 32 day0 day0 NN cord-005453-4057qib7 11595 33 , , , cord-005453-4057qib7 11595 34 cytarabine cytarabine RB cord-005453-4057qib7 11595 35 2 2 CD cord-005453-4057qib7 11595 36 g g NN cord-005453-4057qib7 11595 37 q12 q12 NN cord-005453-4057qib7 11595 38 day day NN cord-005453-4057qib7 11595 39 1 1 CD cord-005453-4057qib7 11595 40 , , , cord-005453-4057qib7 11596 1 Cisplatin cisplatin NN cord-005453-4057qib7 11596 2 100 100 CD cord-005453-4057qib7 11596 3 mg mg NNP cord-005453-4057qib7 11596 4 day day NN cord-005453-4057qib7 11596 5 1,dexamethasone 1,dexamethasone CD cord-005453-4057qib7 11596 6 20 20 CD cord-005453-4057qib7 11596 7 mg mg RB cord-005453-4057qib7 11596 8 from from IN cord-005453-4057qib7 11596 9 day day NN cord-005453-4057qib7 11596 10 1 1 CD cord-005453-4057qib7 11596 11 to to IN cord-005453-4057qib7 11596 12 5)in 5)in CD cord-005453-4057qib7 11596 13 succession succession NN cord-005453-4057qib7 11596 14 . . . cord-005453-4057qib7 11597 1 Because because IN cord-005453-4057qib7 11597 2 of of IN cord-005453-4057qib7 11597 3 the the DT cord-005453-4057qib7 11597 4 failure failure NN cord-005453-4057qib7 11597 5 to to TO cord-005453-4057qib7 11597 6 control control VB cord-005453-4057qib7 11597 7 disease disease NN cord-005453-4057qib7 11597 8 progression progression NN cord-005453-4057qib7 11597 9 , , , cord-005453-4057qib7 11597 10 ibrutinib ibrutinib NNP cord-005453-4057qib7 11598 1 560 560 CD cord-005453-4057qib7 11598 2 mg mg NN cord-005453-4057qib7 11598 3 qd qd NNP cord-005453-4057qib7 11598 4 was be VBD cord-005453-4057qib7 11598 5 used use VBN cord-005453-4057qib7 11598 6 until until IN cord-005453-4057qib7 11598 7 the the DT cord-005453-4057qib7 11598 8 patient patient NN cord-005453-4057qib7 11598 9 died die VBD cord-005453-4057qib7 11598 10 . . . cord-005453-4057qib7 11599 1 Results result NNS cord-005453-4057qib7 11599 2 : : : cord-005453-4057qib7 11600 1 The the DT cord-005453-4057qib7 11600 2 64-year 64-year JJ cord-005453-4057qib7 11600 3 - - HYPH cord-005453-4057qib7 11600 4 old old JJ cord-005453-4057qib7 11600 5 man man NN cord-005453-4057qib7 11600 6 initially initially RB cord-005453-4057qib7 11600 7 referred refer VBD cord-005453-4057qib7 11600 8 to to IN cord-005453-4057qib7 11600 9 our -PRON- PRP$ cord-005453-4057qib7 11600 10 hospital hospital NN cord-005453-4057qib7 11600 11 for for IN cord-005453-4057qib7 11600 12 complaints complaint NNS cord-005453-4057qib7 11600 13 of of IN cord-005453-4057qib7 11600 14 abdominal abdominal JJ cord-005453-4057qib7 11600 15 pain pain NN cord-005453-4057qib7 11600 16 and and CC cord-005453-4057qib7 11600 17 distention distention NN cord-005453-4057qib7 11600 18 over over IN cord-005453-4057qib7 11600 19 2 2 CD cord-005453-4057qib7 11600 20 months month NNS cord-005453-4057qib7 11600 21 . . . cord-005453-4057qib7 11601 1 Ultrasound ultrasound NN cord-005453-4057qib7 11601 2 showed show VBD cord-005453-4057qib7 11601 3 splenomegaly splenomegaly JJ cord-005453-4057qib7 11601 4 and and CC cord-005453-4057qib7 11601 5 multiple multiple JJ cord-005453-4057qib7 11601 6 enlarged enlarged JJ cord-005453-4057qib7 11601 7 retroperitoneal retroperitoneal JJ cord-005453-4057qib7 11601 8 lymph lymph NN cord-005453-4057qib7 11601 9 nodes node NNS cord-005453-4057qib7 11601 10 . . . cord-005453-4057qib7 11602 1 Excisional Excisional NNP cord-005453-4057qib7 11602 2 biopsy biopsy NN cord-005453-4057qib7 11602 3 conducted conduct VBN cord-005453-4057qib7 11602 4 on on IN cord-005453-4057qib7 11602 5 the the DT cord-005453-4057qib7 11602 6 right right JJ cord-005453-4057qib7 11602 7 neck neck NN cord-005453-4057qib7 11602 8 lymph lymph NN cord-005453-4057qib7 11602 9 node node NN cord-005453-4057qib7 11602 10 revealed reveal VBD cord-005453-4057qib7 11602 11 the the DT cord-005453-4057qib7 11602 12 presence presence NN cord-005453-4057qib7 11602 13 of of IN cord-005453-4057qib7 11602 14 malignant malignant JJ cord-005453-4057qib7 11602 15 cells cell NNS cord-005453-4057qib7 11602 16 . . . cord-005453-4057qib7 11603 1 Immunohistochemically immunohistochemically RB cord-005453-4057qib7 11603 2 , , , cord-005453-4057qib7 11603 3 the the DT cord-005453-4057qib7 11603 4 neoplastic neoplastic JJ cord-005453-4057qib7 11603 5 cells cell NNS cord-005453-4057qib7 11603 6 were be VBD cord-005453-4057qib7 11603 7 positive positive JJ cord-005453-4057qib7 11603 8 for for IN cord-005453-4057qib7 11603 9 Bcl2 Bcl2 NNP cord-005453-4057qib7 11603 10 , , , cord-005453-4057qib7 11603 11 Bcl6,CD20 Bcl6,CD20 NNP cord-005453-4057qib7 11603 12 , , , cord-005453-4057qib7 11603 13 CD5 CD5 NNP cord-005453-4057qib7 11603 14 , , , cord-005453-4057qib7 11603 15 CD79a CD79a NNP cord-005453-4057qib7 11603 16 , , , cord-005453-4057qib7 11603 17 CD43 CD43 NNP cord-005453-4057qib7 11603 18 , , , cord-005453-4057qib7 11603 19 Ki-67(50 ki-67(50 NN cord-005453-4057qib7 11603 20 % % NN cord-005453-4057qib7 11603 21 ) ) -RRB- cord-005453-4057qib7 11603 22 , , , cord-005453-4057qib7 11603 23 SOX11 SOX11 NNP cord-005453-4057qib7 11603 24 , , , cord-005453-4057qib7 11603 25 CD21 CD21 NNP cord-005453-4057qib7 11603 26 ( ( -LRB- cord-005453-4057qib7 11603 27 FDC FDC NNP cord-005453-4057qib7 11603 28 ) ) -RRB- cord-005453-4057qib7 11603 29 and and CC cord-005453-4057qib7 11603 30 Cyclin Cyclin NNP cord-005453-4057qib7 11603 31 D1 D1 NNP cord-005453-4057qib7 11603 32 and and CC cord-005453-4057qib7 11603 33 negative negative JJ cord-005453-4057qib7 11603 34 for for IN cord-005453-4057qib7 11603 35 CD10 CD10 NNP cord-005453-4057qib7 11603 36 , , , cord-005453-4057qib7 11603 37 CD23 CD23 NNP cord-005453-4057qib7 11603 38 and and CC cord-005453-4057qib7 11603 39 CD3 CD3 NNP cord-005453-4057qib7 11603 40 ; ; : cord-005453-4057qib7 11603 41 Fluorescence Fluorescence NNP cord-005453-4057qib7 11603 42 In in IN cord-005453-4057qib7 11603 43 Situ Situ NNP cord-005453-4057qib7 11603 44 Hybridization(FISH Hybridization(FISH NNP cord-005453-4057qib7 11603 45 ) ) -RRB- cord-005453-4057qib7 11603 46 showed show VBD cord-005453-4057qib7 11603 47 IGH/ igh/ NN cord-005453-4057qib7 11603 48 CCND1,t(11;14 ccnd1,t(11;14 NN cord-005453-4057qib7 11603 49 ) ) -RRB- cord-005453-4057qib7 11604 1 90%.Thus 90%.thus LS cord-005453-4057qib7 11604 2 a a DT cord-005453-4057qib7 11604 3 diagnosis diagnosis NN cord-005453-4057qib7 11604 4 of of IN cord-005453-4057qib7 11604 5 MCL MCL NNP cord-005453-4057qib7 11604 6 was be VBD cord-005453-4057qib7 11604 7 confirmed confirm VBN cord-005453-4057qib7 11604 8 . . . cord-005453-4057qib7 11605 1 2 2 LS cord-005453-4057qib7 11605 2 course course NN cord-005453-4057qib7 11605 3 of of IN cord-005453-4057qib7 11605 4 therapeutic therapeutic JJ cord-005453-4057qib7 11605 5 chemotherapy chemotherapy NN cord-005453-4057qib7 11605 6 were be VBD cord-005453-4057qib7 11605 7 applied apply VBN cord-005453-4057qib7 11605 8 to to IN cord-005453-4057qib7 11605 9 the the DT cord-005453-4057qib7 11605 10 patient patient NN cord-005453-4057qib7 11605 11 but but CC cord-005453-4057qib7 11605 12 he -PRON- PRP cord-005453-4057qib7 11605 13 did do VBD cord-005453-4057qib7 11605 14 not not RB cord-005453-4057qib7 11605 15 respond respond VB cord-005453-4057qib7 11605 16 well well RB cord-005453-4057qib7 11605 17 . . . cord-005453-4057qib7 11606 1 He -PRON- PRP cord-005453-4057qib7 11606 2 suffered suffer VBD cord-005453-4057qib7 11606 3 recurrent recurrent JJ cord-005453-4057qib7 11606 4 fever fever NN cord-005453-4057qib7 11606 5 , , , cord-005453-4057qib7 11606 6 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 11606 7 , , , cord-005453-4057qib7 11606 8 left leave VBD cord-005453-4057qib7 11606 9 abdominal abdominal JJ cord-005453-4057qib7 11606 10 pain pain NN cord-005453-4057qib7 11606 11 , , , cord-005453-4057qib7 11606 12 splenomegaly splenomegaly NN cord-005453-4057qib7 11606 13 and and CC cord-005453-4057qib7 11606 14 multiple multiple JJ cord-005453-4057qib7 11606 15 enlarged enlarged JJ cord-005453-4057qib7 11606 16 lymph lymph NN cord-005453-4057qib7 11606 17 nodes node NNS cord-005453-4057qib7 11606 18 . . . cord-005453-4057qib7 11607 1 Then then RB cord-005453-4057qib7 11607 2 he -PRON- PRP cord-005453-4057qib7 11607 3 received receive VBD cord-005453-4057qib7 11607 4 ibrutinib ibrutinib NNP cord-005453-4057qib7 11607 5 mono mono NN cord-005453-4057qib7 11607 6 - - HYPH cord-005453-4057qib7 11607 7 therapy therapy NN cord-005453-4057qib7 11607 8 , , , cord-005453-4057qib7 11607 9 and and CC cord-005453-4057qib7 11607 10 experienced experience VBD cord-005453-4057qib7 11607 11 a a DT cord-005453-4057qib7 11607 12 dramatic dramatic JJ cord-005453-4057qib7 11607 13 improvement improvement NN cord-005453-4057qib7 11607 14 as as IN cord-005453-4057qib7 11607 15 his -PRON- PRP$ cord-005453-4057qib7 11607 16 body body NN cord-005453-4057qib7 11607 17 temperature temperature NN cord-005453-4057qib7 11607 18 was be VBD cord-005453-4057qib7 11607 19 controlled control VBN cord-005453-4057qib7 11607 20 , , , cord-005453-4057qib7 11607 21 his -PRON- PRP$ cord-005453-4057qib7 11607 22 hemogram hemogram NN cord-005453-4057qib7 11607 23 became become VBD cord-005453-4057qib7 11607 24 normal normal JJ cord-005453-4057qib7 11607 25 and and CC cord-005453-4057qib7 11607 26 his -PRON- PRP$ cord-005453-4057qib7 11607 27 spleen spleen NNS cord-005453-4057qib7 11607 28 and and CC cord-005453-4057qib7 11607 29 lymph lymph NN cord-005453-4057qib7 11607 30 node node NN cord-005453-4057qib7 11607 31 tapered taper VBN cord-005453-4057qib7 11607 32 . . . cord-005453-4057qib7 11608 1 After after IN cord-005453-4057qib7 11608 2 about about RB cord-005453-4057qib7 11608 3 6 6 CD cord-005453-4057qib7 11608 4 months month NNS cord-005453-4057qib7 11608 5 response response NN cord-005453-4057qib7 11608 6 of of IN cord-005453-4057qib7 11608 7 ibrutinib ibrutinib NNP cord-005453-4057qib7 11608 8 , , , cord-005453-4057qib7 11608 9 the the DT cord-005453-4057qib7 11608 10 disease disease NN cord-005453-4057qib7 11608 11 deteriorated deteriorate VBD cord-005453-4057qib7 11608 12 rapidly rapidly RB cord-005453-4057qib7 11608 13 and and CC cord-005453-4057qib7 11608 14 he -PRON- PRP cord-005453-4057qib7 11608 15 died die VBD cord-005453-4057qib7 11608 16 very very RB cord-005453-4057qib7 11608 17 soon soon RB cord-005453-4057qib7 11608 18 . . . cord-005453-4057qib7 11609 1 Exome Exome NNP cord-005453-4057qib7 11609 2 sequencing sequencing NN cord-005453-4057qib7 11609 3 from from IN cord-005453-4057qib7 11609 4 the the DT cord-005453-4057qib7 11609 5 patient patient JJ cord-005453-4057qib7 11609 6 peripheral peripheral JJ cord-005453-4057qib7 11609 7 blood blood NN cord-005453-4057qib7 11609 8 at at IN cord-005453-4057qib7 11609 9 this this DT cord-005453-4057qib7 11609 10 time time NN cord-005453-4057qib7 11609 11 detected detect VBD cord-005453-4057qib7 11609 12 one one CD cord-005453-4057qib7 11609 13 missense missense JJ cord-005453-4057qib7 11609 14 mutation mutation NN cord-005453-4057qib7 11609 15 in in IN cord-005453-4057qib7 11609 16 exon exon NN cord-005453-4057qib7 11609 17 5 5 CD cord-005453-4057qib7 11609 18 of of IN cord-005453-4057qib7 11609 19 TP53 TP53 NNP cord-005453-4057qib7 11609 20 at at IN cord-005453-4057qib7 11609 21 nucleotide nucleotide JJ cord-005453-4057qib7 11609 22 524 524 CD cord-005453-4057qib7 11609 23 G g NN cord-005453-4057qib7 11610 1 > > XX cord-005453-4057qib7 11611 1 A a DT cord-005453-4057qib7 11611 2 , , , cord-005453-4057qib7 11611 3 resulting result VBG cord-005453-4057qib7 11611 4 in in IN cord-005453-4057qib7 11611 5 an an DT cord-005453-4057qib7 11611 6 Argnine Argnine NNP cord-005453-4057qib7 11611 7 to to IN cord-005453-4057qib7 11611 8 Histidine Histidine NNP cord-005453-4057qib7 11611 9 change change NN cord-005453-4057qib7 11611 10 at at IN cord-005453-4057qib7 11611 11 amino amino NN cord-005453-4057qib7 11611 12 acid acid NN cord-005453-4057qib7 11611 13 175 175 CD cord-005453-4057qib7 11612 1 ( ( -LRB- cord-005453-4057qib7 11612 2 p p NN cord-005453-4057qib7 11612 3 . . . cord-005453-4057qib7 11612 4 Arg175His Arg175His '' cord-005453-4057qib7 11612 5 ) ) -RRB- cord-005453-4057qib7 11612 6 . . . cord-005453-4057qib7 11613 1 But but CC cord-005453-4057qib7 11613 2 Sanger Sanger NNP cord-005453-4057qib7 11613 3 sequencing sequencing NN cord-005453-4057qib7 11613 4 of of IN cord-005453-4057qib7 11613 5 the the DT cord-005453-4057qib7 11613 6 patient patient NN cord-005453-4057qib7 11613 7 bone bone NN cord-005453-4057qib7 11613 8 marrow marrow NN cord-005453-4057qib7 11613 9 FFPE FFPE NNP cord-005453-4057qib7 11613 10 sample sample NN cord-005453-4057qib7 11613 11 at at IN cord-005453-4057qib7 11613 12 the the DT cord-005453-4057qib7 11613 13 time time NN cord-005453-4057qib7 11613 14 of of IN cord-005453-4057qib7 11613 15 original original JJ cord-005453-4057qib7 11613 16 diagnosis diagnosis NN cord-005453-4057qib7 11613 17 did do VBD cord-005453-4057qib7 11613 18 not not RB cord-005453-4057qib7 11613 19 detect detect VB cord-005453-4057qib7 11613 20 this this DT cord-005453-4057qib7 11613 21 mutation mutation NN cord-005453-4057qib7 11613 22 . . . cord-005453-4057qib7 11614 1 Conclusions conclusion NNS cord-005453-4057qib7 11614 2 : : : cord-005453-4057qib7 11615 1 Thus thus RB cord-005453-4057qib7 11615 2 , , , cord-005453-4057qib7 11615 3 our -PRON- PRP$ cord-005453-4057qib7 11615 4 study study NN cord-005453-4057qib7 11615 5 reported report VBD cord-005453-4057qib7 11615 6 a a DT cord-005453-4057qib7 11615 7 TP53 TP53 NNP cord-005453-4057qib7 11615 8 R175H r175h NN cord-005453-4057qib7 11615 9 mutation mutation NN cord-005453-4057qib7 11615 10 MCL mcl NN cord-005453-4057qib7 11615 11 patient patient NN cord-005453-4057qib7 11615 12 who who WP cord-005453-4057qib7 11615 13 developed develop VBD cord-005453-4057qib7 11615 14 ibrutinib ibrutinib NN cord-005453-4057qib7 11615 15 resistance resistance NN cord-005453-4057qib7 11615 16 and and CC cord-005453-4057qib7 11615 17 progressed progress VBD cord-005453-4057qib7 11615 18 aggresively aggresively RB cord-005453-4057qib7 11615 19 , , , cord-005453-4057qib7 11615 20 which which WDT cord-005453-4057qib7 11615 21 may may MD cord-005453-4057qib7 11615 22 open open VB cord-005453-4057qib7 11615 23 new new JJ cord-005453-4057qib7 11615 24 insight insight NN cord-005453-4057qib7 11615 25 for for IN cord-005453-4057qib7 11615 26 future future JJ cord-005453-4057qib7 11615 27 effort effort NN cord-005453-4057qib7 11615 28 for for IN cord-005453-4057qib7 11615 29 alternative alternative JJ cord-005453-4057qib7 11615 30 therapeutic therapeutic JJ cord-005453-4057qib7 11615 31 strategies strategy NNS cord-005453-4057qib7 11615 32 in in IN cord-005453-4057qib7 11615 33 ibrutinib ibrutinib NN cord-005453-4057qib7 11615 34 - - HYPH cord-005453-4057qib7 11615 35 refractory refractory JJ cord-005453-4057qib7 11615 36 MCL mcl NN cord-005453-4057qib7 11615 37 . . . cord-005453-4057qib7 11616 1 Disclosure disclosure NN cord-005453-4057qib7 11616 2 : : : cord-005453-4057qib7 11616 3 Nothing nothing NN cord-005453-4057qib7 11616 4 to to TO cord-005453-4057qib7 11616 5 declare declare VB cord-005453-4057qib7 11616 6 . . . cord-005453-4057qib7 11617 1 Minimal minimal JJ cord-005453-4057qib7 11617 2 residual residual JJ cord-005453-4057qib7 11617 3 disease disease NN cord-005453-4057qib7 11617 4 , , , cord-005453-4057qib7 11617 5 tolerance tolerance NN cord-005453-4057qib7 11617 6 , , , cord-005453-4057qib7 11617 7 chimerism chimerism NN cord-005453-4057qib7 11617 8 and and CC cord-005453-4057qib7 11617 9 immune immune JJ cord-005453-4057qib7 11617 10 reconstitution reconstitution NN cord-005453-4057qib7 11617 11 Peripheral peripheral JJ cord-005453-4057qib7 11617 12 blood blood NN cord-005453-4057qib7 11617 13 samples sample NNS cord-005453-4057qib7 11617 14 were be VBD cord-005453-4057qib7 11617 15 obtained obtain VBN cord-005453-4057qib7 11617 16 for for IN cord-005453-4057qib7 11617 17 routine routine JJ cord-005453-4057qib7 11617 18 analysis analysis NN cord-005453-4057qib7 11617 19 at at IN cord-005453-4057qib7 11617 20 several several JJ cord-005453-4057qib7 11617 21 time time NN cord-005453-4057qib7 11617 22 points point NNS cord-005453-4057qib7 11617 23 after after IN cord-005453-4057qib7 11617 24 HSCT HSCT NNP cord-005453-4057qib7 11617 25 . . . cord-005453-4057qib7 11618 1 All all DT cord-005453-4057qib7 11618 2 available available JJ cord-005453-4057qib7 11618 3 blood blood NN cord-005453-4057qib7 11618 4 samples sample NNS cord-005453-4057qib7 11618 5 between between IN cord-005453-4057qib7 11618 6 0.5 0.5 CD cord-005453-4057qib7 11618 7 and and CC cord-005453-4057qib7 11618 8 2 2 CD cord-005453-4057qib7 11618 9 years year NNS cord-005453-4057qib7 11618 10 were be VBD cord-005453-4057qib7 11618 11 used use VBN cord-005453-4057qib7 11618 12 in in IN cord-005453-4057qib7 11618 13 the the DT cord-005453-4057qib7 11618 14 analysis analysis NN cord-005453-4057qib7 11618 15 . . . cord-005453-4057qib7 11619 1 To to TO cord-005453-4057qib7 11619 2 assess assess VB cord-005453-4057qib7 11619 3 changes change NNS cord-005453-4057qib7 11619 4 in in IN cord-005453-4057qib7 11619 5 the the DT cord-005453-4057qib7 11619 6 CD19+B CD19+B NNP cord-005453-4057qib7 11619 7 and and CC cord-005453-4057qib7 11619 8 CD19 CD19 NNP cord-005453-4057qib7 11619 9 + + CC cord-005453-4057qib7 11619 10 CD27+memory cd27+memory NN cord-005453-4057qib7 11619 11 B b NN cord-005453-4057qib7 11619 12 cell cell NN cord-005453-4057qib7 11619 13 counts count VBZ cord-005453-4057qib7 11619 14 over over IN cord-005453-4057qib7 11619 15 time time NN cord-005453-4057qib7 11619 16 while while IN cord-005453-4057qib7 11619 17 accounting account VBG cord-005453-4057qib7 11619 18 for for IN cord-005453-4057qib7 11619 19 the the DT cord-005453-4057qib7 11619 20 correlation correlation NN cord-005453-4057qib7 11619 21 between between IN cord-005453-4057qib7 11619 22 the the DT cord-005453-4057qib7 11619 23 repeated repeat VBN cord-005453-4057qib7 11619 24 measurements measurement NNS cord-005453-4057qib7 11619 25 of of IN cord-005453-4057qib7 11619 26 each each DT cord-005453-4057qib7 11619 27 patient patient NN cord-005453-4057qib7 11619 28 , , , cord-005453-4057qib7 11619 29 we -PRON- PRP cord-005453-4057qib7 11619 30 used use VBD cord-005453-4057qib7 11619 31 linear linear JJ cord-005453-4057qib7 11619 32 mixed mixed JJ cord-005453-4057qib7 11619 33 - - HYPH cord-005453-4057qib7 11619 34 effects effect NNS cord-005453-4057qib7 11619 35 models model NNS cord-005453-4057qib7 11619 36 . . . cord-005453-4057qib7 11620 1 Wilcoxon Wilcoxon NNP cord-005453-4057qib7 11620 2 rank rank NN cord-005453-4057qib7 11620 3 test test NN cord-005453-4057qib7 11620 4 , , , cord-005453-4057qib7 11620 5 Kruskal Kruskal NNP cord-005453-4057qib7 11620 6 - - HYPH cord-005453-4057qib7 11620 7 Wallis Wallis NNP cord-005453-4057qib7 11620 8 test test NN cord-005453-4057qib7 11620 9 and and CC cord-005453-4057qib7 11620 10 linear linear JJ cord-005453-4057qib7 11620 11 regression regression NN cord-005453-4057qib7 11620 12 were be VBD cord-005453-4057qib7 11620 13 used use VBN cord-005453-4057qib7 11620 14 for for IN cord-005453-4057qib7 11620 15 univariate univariate JJ cord-005453-4057qib7 11620 16 analysis analysis NN cord-005453-4057qib7 11620 17 . . . cord-005453-4057qib7 11621 1 Results result NNS cord-005453-4057qib7 11621 2 : : : cord-005453-4057qib7 11622 1 At at IN cord-005453-4057qib7 11622 2 one one CD cord-005453-4057qib7 11622 3 year year NN cord-005453-4057qib7 11622 4 after after IN cord-005453-4057qib7 11622 5 HSCT HSCT NNP cord-005453-4057qib7 11622 6 , , , cord-005453-4057qib7 11622 7 univariate univariate JJ cord-005453-4057qib7 11622 8 analysis analysis NN cord-005453-4057qib7 11622 9 showed show VBD cord-005453-4057qib7 11622 10 that that IN cord-005453-4057qib7 11622 11 patients patient NNS cord-005453-4057qib7 11622 12 transplanted transplant VBN cord-005453-4057qib7 11622 13 with with IN cord-005453-4057qib7 11622 14 a a DT cord-005453-4057qib7 11622 15 CB CB NNP cord-005453-4057qib7 11622 16 graft graft NN cord-005453-4057qib7 11622 17 compared compare VBN cord-005453-4057qib7 11622 18 to to IN cord-005453-4057qib7 11622 19 BM BM NNP cord-005453-4057qib7 11622 20 and and CC cord-005453-4057qib7 11622 21 PBSC PBSC NNP cord-005453-4057qib7 11622 22 had have VBD cord-005453-4057qib7 11622 23 a a DT cord-005453-4057qib7 11622 24 significantly significantly RB cord-005453-4057qib7 11622 25 higher high JJR cord-005453-4057qib7 11622 26 absolute absolute JJ cord-005453-4057qib7 11622 27 number number NN cord-005453-4057qib7 11622 28 of of IN cord-005453-4057qib7 11622 29 B b NN cord-005453-4057qib7 11622 30 cells cell NNS cord-005453-4057qib7 11622 31 ( ( -LRB- cord-005453-4057qib7 11622 32 median median NN cord-005453-4057qib7 11622 33 BM= BM= NNP cord-005453-4057qib7 11622 34 501 501 CD cord-005453-4057qib7 11622 35 , , , cord-005453-4057qib7 11622 36 median median NN cord-005453-4057qib7 11622 37 CB=1402 cb=1402 NN cord-005453-4057qib7 11622 38 , , , cord-005453-4057qib7 11622 39 median median JJ cord-005453-4057qib7 11622 40 PBSC=502 pbsc=502 NN cord-005453-4057qib7 11622 41 cells/ cells/ CD cord-005453-4057qib7 11623 1 μl μl UH cord-005453-4057qib7 11623 2 , , , cord-005453-4057qib7 11623 3 P=1.4e-5 P=1.4e-5 NNP cord-005453-4057qib7 11623 4 ) ) -RRB- cord-005453-4057qib7 11624 1 and and CC cord-005453-4057qib7 11624 2 memory memory NN cord-005453-4057qib7 11624 3 B b NN cord-005453-4057qib7 11624 4 cells cell NNS cord-005453-4057qib7 11624 5 ( ( -LRB- cord-005453-4057qib7 11624 6 median median JJ cord-005453-4057qib7 11624 7 BM= BM= NNP cord-005453-4057qib7 11624 8 26 26 CD cord-005453-4057qib7 11624 9 , , , cord-005453-4057qib7 11624 10 median median NN cord-005453-4057qib7 11624 11 CB=75 CB=75 NNP cord-005453-4057qib7 11624 12 , , , cord-005453-4057qib7 11624 13 median median JJ cord-005453-4057qib7 11624 14 PBSC=23 PBSC=23 NNP cord-005453-4057qib7 11624 15 cells/ cells/ CD cord-005453-4057qib7 11625 1 μl μl UH cord-005453-4057qib7 11625 2 , , , cord-005453-4057qib7 11625 3 . . . cord-005453-4057qib7 11626 1 Recipients recipient NNS cord-005453-4057qib7 11626 2 with with IN cord-005453-4057qib7 11626 3 age age NN cord-005453-4057qib7 11626 4 under under IN cord-005453-4057qib7 11626 5 5 5 CD cord-005453-4057qib7 11626 6 years year NNS cord-005453-4057qib7 11626 7 had have VBD cord-005453-4057qib7 11626 8 significantly significantly RB cord-005453-4057qib7 11626 9 higher high JJR cord-005453-4057qib7 11626 10 absolute absolute JJ cord-005453-4057qib7 11626 11 numbers number NNS cord-005453-4057qib7 11626 12 of of IN cord-005453-4057qib7 11626 13 B b NN cord-005453-4057qib7 11626 14 ( ( -LRB- cord-005453-4057qib7 11626 15 median=919 median=919 NNP cord-005453-4057qib7 11626 16 , , , cord-005453-4057qib7 11626 17 median=473 median=473 NN cord-005453-4057qib7 11626 18 cells/ cells/ CD cord-005453-4057qib7 11627 1 μl μl UH cord-005453-4057qib7 11627 2 , , , cord-005453-4057qib7 11627 3 P=2.9e-4 p=2.9e-4 ADD cord-005453-4057qib7 11627 4 ) ) -RRB- cord-005453-4057qib7 11627 5 and and CC cord-005453-4057qib7 11627 6 memory memory NN cord-005453-4057qib7 11627 7 B b NN cord-005453-4057qib7 11627 8 cells cell NNS cord-005453-4057qib7 11627 9 ( ( -LRB- cord-005453-4057qib7 11627 10 median=54 median=54 NNP cord-005453-4057qib7 11627 11 , , , cord-005453-4057qib7 11627 12 median=22 median=22 NNP cord-005453-4057qib7 11627 13 cells cell NNS cord-005453-4057qib7 11627 14 / / SYM cord-005453-4057qib7 11627 15 μl μl NN cord-005453-4057qib7 11627 16 , , , cord-005453-4057qib7 11627 17 P=2.7e-5 p=2.7e-5 NN cord-005453-4057qib7 11627 18 ) ) -RRB- cord-005453-4057qib7 11628 1 than than IN cord-005453-4057qib7 11628 2 above above IN cord-005453-4057qib7 11628 3 5 5 CD cord-005453-4057qib7 11628 4 years year NNS cord-005453-4057qib7 11628 5 . . . cord-005453-4057qib7 11629 1 Increase increase VB cord-005453-4057qib7 11629 2 in in IN cord-005453-4057qib7 11629 3 donor donor NN cord-005453-4057qib7 11629 4 age age NN cord-005453-4057qib7 11629 5 was be VBD cord-005453-4057qib7 11629 6 associated associate VBN cord-005453-4057qib7 11629 7 with with IN cord-005453-4057qib7 11629 8 a a DT cord-005453-4057qib7 11629 9 decreasing decrease VBG cord-005453-4057qib7 11629 10 effect effect NN cord-005453-4057qib7 11629 11 on on IN cord-005453-4057qib7 11629 12 B b NN cord-005453-4057qib7 11629 13 cell cell NN cord-005453-4057qib7 11630 1 ( ( -LRB- cord-005453-4057qib7 11630 2 R r NN cord-005453-4057qib7 11630 3 2 2 CD cord-005453-4057qib7 11630 4 = = SYM cord-005453-4057qib7 11630 5 0.35 0.35 CD cord-005453-4057qib7 11630 6 , , , cord-005453-4057qib7 11630 7 P=5.9e-14 P=5.9e-14 NNP cord-005453-4057qib7 11630 8 ) ) -RRB- cord-005453-4057qib7 11630 9 and and CC cord-005453-4057qib7 11630 10 memory memory NN cord-005453-4057qib7 11630 11 B b NN cord-005453-4057qib7 11630 12 cell cell NN cord-005453-4057qib7 11630 13 ( ( -LRB- cord-005453-4057qib7 11630 14 R r NN cord-005453-4057qib7 11630 15 2 2 CD cord-005453-4057qib7 11630 16 = = SYM cord-005453-4057qib7 11630 17 0.25 0.25 CD cord-005453-4057qib7 11630 18 , , , cord-005453-4057qib7 11630 19 P=2.1e-8 p=2.1e-8 CD cord-005453-4057qib7 11630 20 ) ) -RRB- cord-005453-4057qib7 11630 21 reconstitution reconstitution NN cord-005453-4057qib7 11630 22 as as IN cord-005453-4057qib7 11630 23 determined determine VBN cord-005453-4057qib7 11630 24 in in IN cord-005453-4057qib7 11630 25 regression regression NN cord-005453-4057qib7 11630 26 analysis analysis NN cord-005453-4057qib7 11630 27 . . . cord-005453-4057qib7 11631 1 Following follow VBG cord-005453-4057qib7 11631 2 univariate univariate JJ cord-005453-4057qib7 11631 3 analysis analysis NN cord-005453-4057qib7 11631 4 , , , cord-005453-4057qib7 11631 5 we -PRON- PRP cord-005453-4057qib7 11631 6 analysed analyse VBD cord-005453-4057qib7 11631 7 these these DT cord-005453-4057qib7 11631 8 factors factor NNS cord-005453-4057qib7 11631 9 in in IN cord-005453-4057qib7 11631 10 a a DT cord-005453-4057qib7 11631 11 mixed mixed JJ cord-005453-4057qib7 11631 12 effects effect NNS cord-005453-4057qib7 11631 13 model model NN cord-005453-4057qib7 11631 14 to to TO cord-005453-4057qib7 11631 15 assess assess VB cord-005453-4057qib7 11631 16 the the DT cord-005453-4057qib7 11631 17 relation relation NN cord-005453-4057qib7 11631 18 with with IN cord-005453-4057qib7 11631 19 differences difference NNS cord-005453-4057qib7 11631 20 in in IN cord-005453-4057qib7 11631 21 B b NN cord-005453-4057qib7 11631 22 cell cell NN cord-005453-4057qib7 11631 23 or or CC cord-005453-4057qib7 11631 24 memory memory NN cord-005453-4057qib7 11631 25 B b NN cord-005453-4057qib7 11631 26 cell cell NN cord-005453-4057qib7 11631 27 numbers number NNS cord-005453-4057qib7 11631 28 0.5 0.5 CD cord-005453-4057qib7 11631 29 - - HYPH cord-005453-4057qib7 11631 30 2 2 CD cord-005453-4057qib7 11631 31 years year NNS cord-005453-4057qib7 11631 32 after after IN cord-005453-4057qib7 11631 33 HSCT HSCT NNP cord-005453-4057qib7 11631 34 . . . cord-005453-4057qib7 11632 1 In in IN cord-005453-4057qib7 11632 2 our -PRON- PRP$ cord-005453-4057qib7 11632 3 analysis analysis NN cord-005453-4057qib7 11632 4 we -PRON- PRP cord-005453-4057qib7 11632 5 found find VBD cord-005453-4057qib7 11632 6 significant significant JJ cord-005453-4057qib7 11632 7 decreasing decrease VBG cord-005453-4057qib7 11632 8 B b NN cord-005453-4057qib7 11632 9 cell cell NN cord-005453-4057qib7 11632 10 and and CC cord-005453-4057qib7 11632 11 memory memory NN cord-005453-4057qib7 11632 12 B b NN cord-005453-4057qib7 11632 13 cell cell NN cord-005453-4057qib7 11632 14 numbers number NNS cord-005453-4057qib7 11632 15 with with IN cord-005453-4057qib7 11632 16 increasing increase VBG cord-005453-4057qib7 11632 17 donor donor NN cord-005453-4057qib7 11632 18 age age NN cord-005453-4057qib7 11632 19 corrected correct VBD cord-005453-4057qib7 11632 20 for for IN cord-005453-4057qib7 11632 21 recipient recipient NN cord-005453-4057qib7 11632 22 age age NN cord-005453-4057qib7 11632 23 and and CC cord-005453-4057qib7 11632 24 source source NN cord-005453-4057qib7 11632 25 ( ( -LRB- cord-005453-4057qib7 11632 26 both both DT cord-005453-4057qib7 11632 27 P p NN cord-005453-4057qib7 11632 28 < < XX cord-005453-4057qib7 11632 29 0.001 0.001 CD cord-005453-4057qib7 11632 30 ) ) -RRB- cord-005453-4057qib7 11632 31 . . . cord-005453-4057qib7 11633 1 Increasing increase VBG cord-005453-4057qib7 11633 2 recipient recipient NN cord-005453-4057qib7 11633 3 age age NN cord-005453-4057qib7 11633 4 also also RB cord-005453-4057qib7 11633 5 showed show VBD cord-005453-4057qib7 11633 6 a a DT cord-005453-4057qib7 11633 7 significant significant JJ cord-005453-4057qib7 11633 8 decrease decrease NN cord-005453-4057qib7 11633 9 in in IN cord-005453-4057qib7 11634 1 B b NN cord-005453-4057qib7 11634 2 cell cell NN cord-005453-4057qib7 11634 3 and and CC cord-005453-4057qib7 11634 4 memory memory NN cord-005453-4057qib7 11634 5 B b NN cord-005453-4057qib7 11634 6 cell cell NN cord-005453-4057qib7 11634 7 numbers number NNS cord-005453-4057qib7 11634 8 ( ( -LRB- cord-005453-4057qib7 11634 9 both both DT cord-005453-4057qib7 11634 10 P p NN cord-005453-4057qib7 11634 11 < < XX cord-005453-4057qib7 11634 12 0.001 0.001 CD cord-005453-4057qib7 11634 13 ) ) -RRB- cord-005453-4057qib7 11634 14 but but CC cord-005453-4057qib7 11635 1 there there EX cord-005453-4057qib7 11635 2 was be VBD cord-005453-4057qib7 11635 3 no no DT cord-005453-4057qib7 11635 4 significant significant JJ cord-005453-4057qib7 11635 5 influence influence NN cord-005453-4057qib7 11635 6 of of IN cord-005453-4057qib7 11635 7 donor donor NN cord-005453-4057qib7 11635 8 source source NN cord-005453-4057qib7 11635 9 ( ( -LRB- cord-005453-4057qib7 11635 10 Figure figure NN cord-005453-4057qib7 11635 11 1 1 CD cord-005453-4057qib7 11635 12 ) ) -RRB- cord-005453-4057qib7 11635 13 . . . cord-005453-4057qib7 11636 1 Conclusions conclusion NNS cord-005453-4057qib7 11636 2 : : : cord-005453-4057qib7 11637 1 B b NN cord-005453-4057qib7 11637 2 cell cell NN cord-005453-4057qib7 11637 3 and and CC cord-005453-4057qib7 11637 4 memory memory NN cord-005453-4057qib7 11637 5 B b NN cord-005453-4057qib7 11637 6 cell cell NN cord-005453-4057qib7 11637 7 numbers number NNS cord-005453-4057qib7 11637 8 after after IN cord-005453-4057qib7 11637 9 HSCT HSCT NNP cord-005453-4057qib7 11637 10 are be VBP cord-005453-4057qib7 11637 11 influenced influence VBN cord-005453-4057qib7 11637 12 by by IN cord-005453-4057qib7 11637 13 donor donor NN cord-005453-4057qib7 11637 14 and and CC cord-005453-4057qib7 11637 15 recipient recipient NN cord-005453-4057qib7 11637 16 age age NN cord-005453-4057qib7 11637 17 but but CC cord-005453-4057qib7 11637 18 not not RB cord-005453-4057qib7 11637 19 by by IN cord-005453-4057qib7 11637 20 donor donor NN cord-005453-4057qib7 11637 21 source source NN cord-005453-4057qib7 11637 22 . . . cord-005453-4057qib7 11638 1 Older old JJR cord-005453-4057qib7 11638 2 donors donor NNS cord-005453-4057qib7 11638 3 and and CC cord-005453-4057qib7 11638 4 recipients recipient NNS cord-005453-4057qib7 11638 5 show show VBP cord-005453-4057qib7 11638 6 a a DT cord-005453-4057qib7 11638 7 decrease decrease NN cord-005453-4057qib7 11638 8 in in IN cord-005453-4057qib7 11638 9 B b NN cord-005453-4057qib7 11638 10 cells cell NNS cord-005453-4057qib7 11638 11 and and CC cord-005453-4057qib7 11638 12 memory memory NN cord-005453-4057qib7 11638 13 B b NN cord-005453-4057qib7 11638 14 cells cell NNS cord-005453-4057qib7 11638 15 numbers number NNS cord-005453-4057qib7 11638 16 0.5 0.5 CD cord-005453-4057qib7 11638 17 - - HYPH cord-005453-4057qib7 11638 18 2 2 CD cord-005453-4057qib7 11638 19 years year NNS cord-005453-4057qib7 11638 20 after after IN cord-005453-4057qib7 11638 21 HSCT HSCT NNP cord-005453-4057qib7 11638 22 . . . cord-005453-4057qib7 11639 1 [ [ -LRB- cord-005453-4057qib7 11639 2 [ [ -LRB- cord-005453-4057qib7 11639 3 P512 P512 NNP cord-005453-4057qib7 11639 4 Image Image NNP cord-005453-4057qib7 11639 5 ] ] -RRB- cord-005453-4057qib7 11639 6 1 1 CD cord-005453-4057qib7 11639 7 . . . cord-005453-4057qib7 11640 1 Figure figure NN cord-005453-4057qib7 11640 2 1 1 CD cord-005453-4057qib7 11640 3 . . . cord-005453-4057qib7 11641 1 B b NN cord-005453-4057qib7 11641 2 cell cell NN cord-005453-4057qib7 11641 3 development development NN cord-005453-4057qib7 11641 4 and and CC cord-005453-4057qib7 11641 5 donor donor NN cord-005453-4057qib7 11641 6 age age NN cord-005453-4057qib7 11641 7 . . . cord-005453-4057qib7 11642 1 Green Green NNP cord-005453-4057qib7 11642 2 shows show VBZ cord-005453-4057qib7 11642 3 CB CB NNP cord-005453-4057qib7 11642 4 , , , cord-005453-4057qib7 11642 5 red red JJ cord-005453-4057qib7 11642 6 BM BM NNP cord-005453-4057qib7 11642 7 , , , cord-005453-4057qib7 11642 8 blue blue JJ cord-005453-4057qib7 11642 9 PBSC PBSC NNP cord-005453-4057qib7 11642 10 at at IN cord-005453-4057qib7 11642 11 mean mean JJ cord-005453-4057qib7 11642 12 donor donor NN cord-005453-4057qib7 11642 13 age age NN cord-005453-4057qib7 11642 14 . . . cord-005453-4057qib7 11642 15 ] ] -RRB- cord-005453-4057qib7 11643 1 1 1 CD cord-005453-4057qib7 11643 2 Copenhagen Copenhagen NNP cord-005453-4057qib7 11643 3 University University NNP cord-005453-4057qib7 11643 4 Hospital Hospital NNP cord-005453-4057qib7 11643 5 Rigshospitalet Rigshospitalet NNP cord-005453-4057qib7 11643 6 , , , cord-005453-4057qib7 11643 7 Copenhagen Copenhagen NNP cord-005453-4057qib7 11643 8 , , , cord-005453-4057qib7 11643 9 Denmark Denmark NNP cord-005453-4057qib7 11643 10 , , , cord-005453-4057qib7 11643 11 2 2 CD cord-005453-4057qib7 11643 12 Leiden Leiden NNP cord-005453-4057qib7 11643 13 University University NNP cord-005453-4057qib7 11643 14 Medical Medical NNP cord-005453-4057qib7 11643 15 Center Center NNP cord-005453-4057qib7 11643 16 , , , cord-005453-4057qib7 11643 17 Leiden Leiden NNP cord-005453-4057qib7 11643 18 , , , cord-005453-4057qib7 11644 1 Netherlands Netherlands NNP cord-005453-4057qib7 11644 2 Background Background NNP cord-005453-4057qib7 11644 3 : : : cord-005453-4057qib7 11645 1 The the DT cord-005453-4057qib7 11645 2 outcome outcome NN cord-005453-4057qib7 11645 3 of of IN cord-005453-4057qib7 11645 4 allogeneic allogeneic NN cord-005453-4057qib7 11645 5 HSCT HSCT NNP cord-005453-4057qib7 11645 6 is be VBZ cord-005453-4057qib7 11645 7 challenged challenge VBN cord-005453-4057qib7 11645 8 by by IN cord-005453-4057qib7 11645 9 a a DT cord-005453-4057qib7 11645 10 delayed delayed JJ cord-005453-4057qib7 11645 11 and and CC cord-005453-4057qib7 11645 12 long long RB cord-005453-4057qib7 11645 13 - - HYPH cord-005453-4057qib7 11645 14 lasting last VBG cord-005453-4057qib7 11645 15 imbalanced imbalanced JJ cord-005453-4057qib7 11645 16 T t NN cord-005453-4057qib7 11645 17 - - HYPH cord-005453-4057qib7 11645 18 cell cell NN cord-005453-4057qib7 11645 19 reconstitution reconstitution NN cord-005453-4057qib7 11645 20 increasing increase VBG cord-005453-4057qib7 11645 21 the the DT cord-005453-4057qib7 11645 22 risk risk NN cord-005453-4057qib7 11645 23 of of IN cord-005453-4057qib7 11645 24 acute acute JJ cord-005453-4057qib7 11645 25 GvHD gvhd NN cord-005453-4057qib7 11645 26 , , , cord-005453-4057qib7 11645 27 infections infection NNS cord-005453-4057qib7 11645 28 and and CC cord-005453-4057qib7 11645 29 disease disease NN cord-005453-4057qib7 11645 30 progression progression NN cord-005453-4057qib7 11645 31 . . . cord-005453-4057qib7 11646 1 Although although IN cord-005453-4057qib7 11646 2 the the DT cord-005453-4057qib7 11646 3 role role NN cord-005453-4057qib7 11646 4 of of IN cord-005453-4057qib7 11646 5 differentially differentially RB cord-005453-4057qib7 11646 6 and and CC cord-005453-4057qib7 11646 7 functionally functionally RB cord-005453-4057qib7 11646 8 distinct distinct JJ cord-005453-4057qib7 11646 9 T t NN cord-005453-4057qib7 11646 10 - - HYPH cord-005453-4057qib7 11646 11 cell cell NN cord-005453-4057qib7 11646 12 subsets subset NNS cord-005453-4057qib7 11646 13 in in IN cord-005453-4057qib7 11646 14 the the DT cord-005453-4057qib7 11646 15 development development NN cord-005453-4057qib7 11646 16 of of IN cord-005453-4057qib7 11646 17 complications complication NNS cord-005453-4057qib7 11646 18 has have VBZ cord-005453-4057qib7 11646 19 been be VBN cord-005453-4057qib7 11646 20 addressed address VBN cord-005453-4057qib7 11646 21 , , , cord-005453-4057qib7 11646 22 little little JJ cord-005453-4057qib7 11646 23 is be VBZ cord-005453-4057qib7 11646 24 known know VBN cord-005453-4057qib7 11646 25 about about IN cord-005453-4057qib7 11646 26 the the DT cord-005453-4057qib7 11646 27 factors factor NNS cord-005453-4057qib7 11646 28 controlling control VBG cord-005453-4057qib7 11646 29 their -PRON- PRP$ cord-005453-4057qib7 11646 30 recovery recovery NN cord-005453-4057qib7 11646 31 . . . cord-005453-4057qib7 11647 1 In in IN cord-005453-4057qib7 11647 2 this this DT cord-005453-4057qib7 11647 3 study study NN cord-005453-4057qib7 11647 4 , , , cord-005453-4057qib7 11647 5 we -PRON- PRP cord-005453-4057qib7 11647 6 investigated investigate VBD cord-005453-4057qib7 11647 7 the the DT cord-005453-4057qib7 11647 8 impact impact NN cord-005453-4057qib7 11647 9 of of IN cord-005453-4057qib7 11647 10 immuneregulating immuneregulate VBG cord-005453-4057qib7 11647 11 and and CC cord-005453-4057qib7 11647 12 homeostatic homeostatic JJ cord-005453-4057qib7 11647 13 cytokines cytokine NNS cord-005453-4057qib7 11647 14 on on IN cord-005453-4057qib7 11647 15 the the DT cord-005453-4057qib7 11647 16 reconstitution reconstitution NN cord-005453-4057qib7 11647 17 of of IN cord-005453-4057qib7 11647 18 functionally functionally RB cord-005453-4057qib7 11647 19 distinct distinct JJ cord-005453-4057qib7 11647 20 T t NN cord-005453-4057qib7 11647 21 - - HYPH cord-005453-4057qib7 11647 22 cell cell NN cord-005453-4057qib7 11647 23 subsets subset NNS cord-005453-4057qib7 11647 24 and and CC cord-005453-4057qib7 11647 25 associated associate VBN cord-005453-4057qib7 11647 26 clinical clinical JJ cord-005453-4057qib7 11647 27 outcomes outcome NNS cord-005453-4057qib7 11647 28 . . . cord-005453-4057qib7 11648 1 Methods method NNS cord-005453-4057qib7 11648 2 : : : cord-005453-4057qib7 11648 3 We -PRON- PRP cord-005453-4057qib7 11648 4 included include VBD cord-005453-4057qib7 11648 5 80 80 CD cord-005453-4057qib7 11648 6 children child NNS cord-005453-4057qib7 11648 7 undergoing undergo VBG cord-005453-4057qib7 11648 8 allogeneic allogeneic IN cord-005453-4057qib7 11648 9 HSCT HSCT NNP cord-005453-4057qib7 11648 10 for for IN cord-005453-4057qib7 11648 11 ALL all DT cord-005453-4057qib7 11648 12 ( ( -LRB- cord-005453-4057qib7 11648 13 n=46 n=46 JJ cord-005453-4057qib7 11648 14 ) ) -RRB- cord-005453-4057qib7 11648 15 or or CC cord-005453-4057qib7 11648 16 AML AML NNP cord-005453-4057qib7 11648 17 ( ( -LRB- cord-005453-4057qib7 11648 18 n=34 n=34 NNP cord-005453-4057qib7 11648 19 ) ) -RRB- cord-005453-4057qib7 11648 20 with with IN cord-005453-4057qib7 11648 21 a a DT cord-005453-4057qib7 11648 22 median median JJ cord-005453-4057qib7 11648 23 age age NN cord-005453-4057qib7 11648 24 of of IN cord-005453-4057qib7 11648 25 8.3 8.3 CD cord-005453-4057qib7 11648 26 years year NNS cord-005453-4057qib7 11649 1 ( ( -LRB- cord-005453-4057qib7 11649 2 range range NN cord-005453-4057qib7 11649 3 : : : cord-005453-4057qib7 11649 4 0.8 0.8 CD cord-005453-4057qib7 11649 5 - - HYPH cord-005453-4057qib7 11649 6 17.8 17.8 CD cord-005453-4057qib7 11649 7 ) ) -RRB- cord-005453-4057qib7 11649 8 . . . cord-005453-4057qib7 11650 1 Donors donor NNS cord-005453-4057qib7 11650 2 were be VBD cord-005453-4057qib7 11650 3 either either CC cord-005453-4057qib7 11650 4 MRD MRD NNP cord-005453-4057qib7 11650 5 ( ( -LRB- cord-005453-4057qib7 11650 6 n=21 n=21 NNP cord-005453-4057qib7 11650 7 ) ) -RRB- cord-005453-4057qib7 11650 8 , , , cord-005453-4057qib7 11650 9 MUD MUD NNP cord-005453-4057qib7 11650 10 ( ( -LRB- cord-005453-4057qib7 11650 11 n=45 n=45 NNS cord-005453-4057qib7 11650 12 ) ) -RRB- cord-005453-4057qib7 11650 13 or or CC cord-005453-4057qib7 11650 14 MMUD MMUD NNP cord-005453-4057qib7 11650 15 ( ( -LRB- cord-005453-4057qib7 11650 16 n=14 n=14 NNP cord-005453-4057qib7 11650 17 ) ) -RRB- cord-005453-4057qib7 11650 18 . . . cord-005453-4057qib7 11651 1 BM BM NNP cord-005453-4057qib7 11651 2 ( ( -LRB- cord-005453-4057qib7 11651 3 n=70 n=70 NNP cord-005453-4057qib7 11651 4 ) ) -RRB- cord-005453-4057qib7 11651 5 or or CC cord-005453-4057qib7 11651 6 PB PB NNP cord-005453-4057qib7 11651 7 ( ( -LRB- cord-005453-4057qib7 11651 8 n=10 n=10 NNP cord-005453-4057qib7 11651 9 ) ) -RRB- cord-005453-4057qib7 11651 10 were be VBD cord-005453-4057qib7 11651 11 used use VBN cord-005453-4057qib7 11651 12 as as IN cord-005453-4057qib7 11651 13 stem stem NN cord-005453-4057qib7 11651 14 cell cell NN cord-005453-4057qib7 11651 15 source source NN cord-005453-4057qib7 11651 16 . . . cord-005453-4057qib7 11652 1 Conditioning conditioning NN cord-005453-4057qib7 11652 2 regimens regimen NNS cord-005453-4057qib7 11652 3 were be VBD cord-005453-4057qib7 11652 4 based base VBN cord-005453-4057qib7 11652 5 on on IN cord-005453-4057qib7 11652 6 TBI TBI NNP cord-005453-4057qib7 11652 7 ( ( -LRB- cord-005453-4057qib7 11652 8 n=25 n=25 NNP cord-005453-4057qib7 11652 9 ) ) -RRB- cord-005453-4057qib7 11652 10 or or CC cord-005453-4057qib7 11652 11 highdose highdose NN cord-005453-4057qib7 11652 12 chemotherapy chemotherapy NN cord-005453-4057qib7 11652 13 alone alone JJ cord-005453-4057qib7 11652 14 ( ( -LRB- cord-005453-4057qib7 11652 15 n=55 n=55 NNP cord-005453-4057qib7 11652 16 ) ) -RRB- cord-005453-4057qib7 11652 17 and and CC cord-005453-4057qib7 11652 18 included include VBD cord-005453-4057qib7 11652 19 ATG ATG NNP cord-005453-4057qib7 11652 20 in in IN cord-005453-4057qib7 11652 21 58 58 CD cord-005453-4057qib7 11652 22 patients patient NNS cord-005453-4057qib7 11652 23 . . . cord-005453-4057qib7 11653 1 Thirty thirty CD cord-005453-4057qib7 11653 2 age age NN cord-005453-4057qib7 11653 3 - - HYPH cord-005453-4057qib7 11653 4 matched match VBN cord-005453-4057qib7 11653 5 healthy healthy JJ cord-005453-4057qib7 11653 6 children child NNS cord-005453-4057qib7 11653 7 were be VBD cord-005453-4057qib7 11653 8 included include VBN cord-005453-4057qib7 11653 9 as as IN cord-005453-4057qib7 11653 10 controls control NNS cord-005453-4057qib7 11653 11 . . . cord-005453-4057qib7 11654 1 Cytokines Cytokines NNP cord-005453-4057qib7 11654 2 ( ( -LRB- cord-005453-4057qib7 11654 3 IL-7 IL-7 NNP cord-005453-4057qib7 11654 4 , , , cord-005453-4057qib7 11654 5 IL-15 IL-15 NNP cord-005453-4057qib7 11654 6 , , , cord-005453-4057qib7 11654 7 IL-18 IL-18 NNP cord-005453-4057qib7 11654 8 , , , cord-005453-4057qib7 11654 9 SCF SCF NNP cord-005453-4057qib7 11654 10 , , , cord-005453-4057qib7 11654 11 IL-6 IL-6 NNP cord-005453-4057qib7 11654 12 , , , cord-005453-4057qib7 11654 13 IL-2 IL-2 NNP cord-005453-4057qib7 11654 14 and and CC cord-005453-4057qib7 11654 15 TNFα TNFα NNP cord-005453-4057qib7 11654 16 ) ) -RRB- cord-005453-4057qib7 11654 17 and and CC cord-005453-4057qib7 11654 18 active active JJ cord-005453-4057qib7 11654 19 ATG ATG NNP cord-005453-4057qib7 11654 20 in in IN cord-005453-4057qib7 11654 21 plasma plasma NN cord-005453-4057qib7 11654 22 were be VBD cord-005453-4057qib7 11654 23 longitudinally longitudinally RB cord-005453-4057qib7 11654 24 measured measure VBN cord-005453-4057qib7 11654 25 from from IN cord-005453-4057qib7 11654 26 before before IN cord-005453-4057qib7 11654 27 conditioning conditioning NN cord-005453-4057qib7 11654 28 until until IN cord-005453-4057qib7 11654 29 3 3 CD cord-005453-4057qib7 11654 30 months month NNS cord-005453-4057qib7 11654 31 after after IN cord-005453-4057qib7 11654 32 HSCT HSCT NNP cord-005453-4057qib7 11654 33 ( ( -LRB- cord-005453-4057qib7 11654 34 n=80 n=80 NNP cord-005453-4057qib7 11654 35 ) ) -RRB- cord-005453-4057qib7 11654 36 along along IN cord-005453-4057qib7 11654 37 with with IN cord-005453-4057qib7 11654 38 an an DT cord-005453-4057qib7 11654 39 extended extended JJ cord-005453-4057qib7 11654 40 phenotyping phenotyping NN cord-005453-4057qib7 11654 41 of of IN cord-005453-4057qib7 11654 42 T t NN cord-005453-4057qib7 11654 43 - - HYPH cord-005453-4057qib7 11654 44 cell cell NN cord-005453-4057qib7 11654 45 maturation maturation NN cord-005453-4057qib7 11654 46 and and CC cord-005453-4057qib7 11654 47 differentiation differentiation NN cord-005453-4057qib7 11654 48 by by IN cord-005453-4057qib7 11654 49 flow flow NN cord-005453-4057qib7 11654 50 cytometry cytometry NN cord-005453-4057qib7 11654 51 ( ( -LRB- cord-005453-4057qib7 11654 52 n=41 n=41 RB cord-005453-4057qib7 11654 53 ) ) -RRB- cord-005453-4057qib7 11654 54 . . . cord-005453-4057qib7 11655 1 Results result NNS cord-005453-4057qib7 11655 2 : : : cord-005453-4057qib7 11656 1 The the DT cord-005453-4057qib7 11656 2 homeostatic homeostatic JJ cord-005453-4057qib7 11656 3 cytokines cytokine NNS cord-005453-4057qib7 11656 4 IL-7 IL-7 NNP cord-005453-4057qib7 11656 5 and and CC cord-005453-4057qib7 11656 6 IL-15 IL-15 NNP cord-005453-4057qib7 11656 7 increased increase VBD cord-005453-4057qib7 11656 8 from from IN cord-005453-4057qib7 11656 9 pre pre JJ cord-005453-4057qib7 11656 10 - - JJ cord-005453-4057qib7 11656 11 conditioning conditioning NN cord-005453-4057qib7 11656 12 to to TO cord-005453-4057qib7 11656 13 peak peak VB cord-005453-4057qib7 11656 14 1 1 CD cord-005453-4057qib7 11656 15 - - SYM cord-005453-4057qib7 11656 16 2 2 CD cord-005453-4057qib7 11656 17 weeks week NNS cord-005453-4057qib7 11656 18 post post NN cord-005453-4057qib7 11656 19 - - JJ cord-005453-4057qib7 11656 20 HSCT HSCT NNP cord-005453-4057qib7 11656 21 and and CC cord-005453-4057qib7 11656 22 gradually gradually RB cord-005453-4057qib7 11656 23 declined decline VBD cord-005453-4057qib7 11656 24 thereafter thereafter RB cord-005453-4057qib7 11656 25 . . . cord-005453-4057qib7 11657 1 IL-6 IL-6 NNP cord-005453-4057qib7 11657 2 levels level NNS cord-005453-4057qib7 11657 3 were be VBD cord-005453-4057qib7 11657 4 shortly shortly RB cord-005453-4057qib7 11657 5 elevated elevate VBN cord-005453-4057qib7 11657 6 , , , cord-005453-4057qib7 11657 7 while while IN cord-005453-4057qib7 11657 8 IL-18 IL-18 NNP cord-005453-4057qib7 11657 9 and and CC cord-005453-4057qib7 11657 10 SCF SCF NNP cord-005453-4057qib7 11657 11 remained remain VBD cord-005453-4057qib7 11657 12 relatively relatively RB cord-005453-4057qib7 11657 13 stable stable JJ cord-005453-4057qib7 11657 14 , , , cord-005453-4057qib7 11657 15 and and CC cord-005453-4057qib7 11657 16 IL-2 IL-2 NNP cord-005453-4057qib7 11657 17 and and CC cord-005453-4057qib7 11657 18 TNF TNF NNP cord-005453-4057qib7 11657 19 - - HYPH cord-005453-4057qib7 11657 20 α α NNP cord-005453-4057qib7 11657 21 levels level NNS cord-005453-4057qib7 11657 22 were be VBD cord-005453-4057qib7 11657 23 below below IN cord-005453-4057qib7 11657 24 threshold threshold NN cord-005453-4057qib7 11657 25 of of IN cord-005453-4057qib7 11657 26 detection detection NN cord-005453-4057qib7 11657 27 at at IN cord-005453-4057qib7 11657 28 all all DT cord-005453-4057qib7 11657 29 time time NN cord-005453-4057qib7 11657 30 points point NNS cord-005453-4057qib7 11657 31 . . . cord-005453-4057qib7 11658 1 The the DT cord-005453-4057qib7 11658 2 early early JJ cord-005453-4057qib7 11658 3 rise rise NN cord-005453-4057qib7 11658 4 of of IN cord-005453-4057qib7 11658 5 IL-7 IL-7 NNP cord-005453-4057qib7 11658 6 and and CC cord-005453-4057qib7 11658 7 IL-15 IL-15 NNP cord-005453-4057qib7 11658 8 was be VBD cord-005453-4057qib7 11658 9 strongly strongly RB cord-005453-4057qib7 11658 10 associated associate VBN cord-005453-4057qib7 11658 11 with with IN cord-005453-4057qib7 11658 12 the the DT cord-005453-4057qib7 11658 13 degree degree NN cord-005453-4057qib7 11658 14 of of IN cord-005453-4057qib7 11658 15 T t NN cord-005453-4057qib7 11658 16 - - HYPH cord-005453-4057qib7 11658 17 cell cell NN cord-005453-4057qib7 11658 18 depletion depletion NN cord-005453-4057qib7 11658 19 by by IN cord-005453-4057qib7 11658 20 ATG ATG NNP cord-005453-4057qib7 11658 21 , , , cord-005453-4057qib7 11658 22 while while IN cord-005453-4057qib7 11658 23 IL-15 IL-15 NNP cord-005453-4057qib7 11658 24 also also RB cord-005453-4057qib7 11658 25 correlated correlate VBD cord-005453-4057qib7 11658 26 with with IN cord-005453-4057qib7 11658 27 markers marker NNS cord-005453-4057qib7 11658 28 of of IN cord-005453-4057qib7 11658 29 systemic systemic JJ cord-005453-4057qib7 11658 30 inflammation inflammation NN cord-005453-4057qib7 11658 31 . . . cord-005453-4057qib7 11659 1 IL-7 IL-7 NNP cord-005453-4057qib7 11659 2 and and CC cord-005453-4057qib7 11659 3 IL-15 IL-15 NNP cord-005453-4057qib7 11659 4 levels level NNS cord-005453-4057qib7 11659 5 were be VBD cord-005453-4057qib7 11659 6 significantly significantly RB cord-005453-4057qib7 11659 7 higher high JJR cord-005453-4057qib7 11659 8 in in IN cord-005453-4057qib7 11659 9 children child NNS cord-005453-4057qib7 11659 10 treated treat VBN cord-005453-4057qib7 11659 11 with with IN cord-005453-4057qib7 11659 12 ATG ATG NNP cord-005453-4057qib7 11659 13 ( ( -LRB- cord-005453-4057qib7 11659 14 P p NN cord-005453-4057qib7 11659 15 < < XX cord-005453-4057qib7 11659 16 0.001 0.001 CD cord-005453-4057qib7 11659 17 ) ) -RRB- cord-005453-4057qib7 11659 18 and and CC cord-005453-4057qib7 11659 19 correlated correlate VBD cord-005453-4057qib7 11659 20 with with IN cord-005453-4057qib7 11659 21 both both DT cord-005453-4057qib7 11659 22 longer long JJR cord-005453-4057qib7 11659 23 exposure exposure NN cord-005453-4057qib7 11659 24 to to IN cord-005453-4057qib7 11659 25 ATG ATG NNP cord-005453-4057qib7 11659 26 ( ( -LRB- cord-005453-4057qib7 11659 27 P p NN cord-005453-4057qib7 11659 28 < < XX cord-005453-4057qib7 11659 29 0.001 0.001 CD cord-005453-4057qib7 11659 30 ) ) -RRB- cord-005453-4057qib7 11659 31 and and CC cord-005453-4057qib7 11659 32 increased increase VBN cord-005453-4057qib7 11659 33 levels level NNS cord-005453-4057qib7 11659 34 of of IN cord-005453-4057qib7 11659 35 active active JJ cord-005453-4057qib7 11659 36 ATG ATG NNP cord-005453-4057qib7 11659 37 ( ( -LRB- cord-005453-4057qib7 11659 38 day day NN cord-005453-4057qib7 11659 39 +21 +21 CD cord-005453-4057qib7 11659 40 : : : cord-005453-4057qib7 11659 41 IL-7 IL-7 NNP cord-005453-4057qib7 11660 1 : : : cord-005453-4057qib7 11660 2 r=0.71 r=0.71 NNP cord-005453-4057qib7 11660 3 , , , cord-005453-4057qib7 11660 4 P p NN cord-005453-4057qib7 11660 5 < < XX cord-005453-4057qib7 11660 6 0.0001 0.0001 CD cord-005453-4057qib7 11660 7 ; ; : cord-005453-4057qib7 11660 8 IL-15 il-15 RB cord-005453-4057qib7 11660 9 : : : cord-005453-4057qib7 11660 10 r=0.61 r=0.61 NNP cord-005453-4057qib7 11660 11 , , , cord-005453-4057qib7 11660 12 P p NN cord-005453-4057qib7 11660 13 < < XX cord-005453-4057qib7 11660 14 0.0001 0.0001 CD cord-005453-4057qib7 11660 15 ) ) -RRB- cord-005453-4057qib7 11660 16 , , , cord-005453-4057qib7 11660 17 indicating indicate VBG cord-005453-4057qib7 11660 18 that that IN cord-005453-4057qib7 11660 19 high high JJ cord-005453-4057qib7 11660 20 levels level NNS cord-005453-4057qib7 11660 21 of of IN cord-005453-4057qib7 11660 22 these these DT cord-005453-4057qib7 11660 23 cytokines cytokine NNS cord-005453-4057qib7 11660 24 reflected reflect VBD cord-005453-4057qib7 11660 25 more more RBR cord-005453-4057qib7 11660 26 pronounced pronounced JJ cord-005453-4057qib7 11660 27 T t NN cord-005453-4057qib7 11660 28 - - HYPH cord-005453-4057qib7 11660 29 cell cell NN cord-005453-4057qib7 11660 30 depletion depletion NN cord-005453-4057qib7 11660 31 during during IN cord-005453-4057qib7 11660 32 lymphopenia lymphopenia NNP cord-005453-4057qib7 11660 33 . . . cord-005453-4057qib7 11661 1 Higher high JJR cord-005453-4057qib7 11661 2 circulating circulate VBG cord-005453-4057qib7 11661 3 levels level NNS cord-005453-4057qib7 11661 4 of of IN cord-005453-4057qib7 11661 5 IL-7 IL-7 NNP cord-005453-4057qib7 11661 6 and and CC cord-005453-4057qib7 11661 7 IL-15 IL-15 NNP cord-005453-4057qib7 11661 8 were be VBD cord-005453-4057qib7 11661 9 associated associate VBN cord-005453-4057qib7 11661 10 with with IN cord-005453-4057qib7 11661 11 a a DT cord-005453-4057qib7 11661 12 slow slow JJ cord-005453-4057qib7 11661 13 recovery recovery NN cord-005453-4057qib7 11661 14 of of IN cord-005453-4057qib7 11661 15 CD3 CD3 NNP cord-005453-4057qib7 11661 16 + + CC cord-005453-4057qib7 11661 17 , , , cord-005453-4057qib7 11661 18 CD4 CD4 NNP cord-005453-4057qib7 11661 19 + + CC cord-005453-4057qib7 11661 20 and and CC cord-005453-4057qib7 11661 21 CD8 CD8 NNP cord-005453-4057qib7 11661 22 + + CC cord-005453-4057qib7 11661 23 T t NN cord-005453-4057qib7 11661 24 - - HYPH cord-005453-4057qib7 11661 25 cell cell NN cord-005453-4057qib7 11661 26 counts count NNS cord-005453-4057qib7 11661 27 at at IN cord-005453-4057qib7 11661 28 day day NN cord-005453-4057qib7 11661 29 +30 +30 CD cord-005453-4057qib7 11661 30 and and CC cord-005453-4057qib7 11661 31 +60 +60 NNP cord-005453-4057qib7 11661 32 post post NN cord-005453-4057qib7 11661 33 - - JJ cord-005453-4057qib7 11661 34 HSCT HSCT NNP cord-005453-4057qib7 11661 35 ( ( -LRB- cord-005453-4057qib7 11661 36 P p NN cord-005453-4057qib7 11661 37 < < XX cord-005453-4057qib7 11661 38 0.05 0.05 CD cord-005453-4057qib7 11661 39 ) ) -RRB- cord-005453-4057qib7 11661 40 , , , cord-005453-4057qib7 11661 41 while while IN cord-005453-4057qib7 11661 42 the the DT cord-005453-4057qib7 11661 43 remaining remain VBG cord-005453-4057qib7 11661 44 cytokines cytokine NNS cord-005453-4057qib7 11661 45 did do VBD cord-005453-4057qib7 11661 46 not not RB cord-005453-4057qib7 11661 47 correlate correlate VB cord-005453-4057qib7 11661 48 with with IN cord-005453-4057qib7 11661 49 immune immune JJ cord-005453-4057qib7 11661 50 reconstitution reconstitution NN cord-005453-4057qib7 11661 51 . . . cord-005453-4057qib7 11662 1 Looking look VBG cord-005453-4057qib7 11662 2 into into IN cord-005453-4057qib7 11662 3 T t NN cord-005453-4057qib7 11662 4 - - HYPH cord-005453-4057qib7 11662 5 cell cell NN cord-005453-4057qib7 11662 6 subpopulations subpopulation NNS cord-005453-4057qib7 11662 7 , , , cord-005453-4057qib7 11662 8 increased increase VBN cord-005453-4057qib7 11662 9 levels level NNS cord-005453-4057qib7 11662 10 of of IN cord-005453-4057qib7 11662 11 IL-7 IL-7 NNP cord-005453-4057qib7 11662 12 and and CC cord-005453-4057qib7 11662 13 IL-15 IL-15 NNP cord-005453-4057qib7 11662 14 during during IN cord-005453-4057qib7 11662 15 the the DT cord-005453-4057qib7 11662 16 first first JJ cord-005453-4057qib7 11662 17 month month NN cord-005453-4057qib7 11662 18 post post NN cord-005453-4057qib7 11662 19 - - NN cord-005453-4057qib7 11662 20 transplant transplant NN cord-005453-4057qib7 11662 21 were be VBD cord-005453-4057qib7 11662 22 associated associate VBN cord-005453-4057qib7 11662 23 with with IN cord-005453-4057qib7 11662 24 lower low JJR cord-005453-4057qib7 11662 25 numbers number NNS cord-005453-4057qib7 11662 26 of of IN cord-005453-4057qib7 11662 27 naïve naïve JJ cord-005453-4057qib7 11662 28 T t NN cord-005453-4057qib7 11662 29 cells cell NNS cord-005453-4057qib7 11662 30 and and CC cord-005453-4057qib7 11662 31 correlated correlate VBD cord-005453-4057qib7 11662 32 with with IN cord-005453-4057qib7 11662 33 an an DT cord-005453-4057qib7 11662 34 increased increase VBN cord-005453-4057qib7 11662 35 proportion proportion NN cord-005453-4057qib7 11662 36 of of IN cord-005453-4057qib7 11662 37 CD4 CD4 NNP cord-005453-4057qib7 11662 38 + + CC cord-005453-4057qib7 11663 1 and and CC cord-005453-4057qib7 11663 2 CD8 CD8 NNP cord-005453-4057qib7 11663 3 + + CC cord-005453-4057qib7 11663 4 effector effector NN cord-005453-4057qib7 11663 5 memory memory NN cord-005453-4057qib7 11663 6 cells cell NNS cord-005453-4057qib7 11663 7 ( ( -LRB- cord-005453-4057qib7 11663 8 Figure figure NN cord-005453-4057qib7 11663 9 ) ) -RRB- cord-005453-4057qib7 11663 10 . . . cord-005453-4057qib7 11664 1 No no DT cord-005453-4057qib7 11664 2 differential differential JJ cord-005453-4057qib7 11664 3 effect effect NN cord-005453-4057qib7 11664 4 of of IN cord-005453-4057qib7 11664 5 cytokines cytokine NNS cord-005453-4057qib7 11664 6 on on IN cord-005453-4057qib7 11664 7 polarization polarization NN cord-005453-4057qib7 11664 8 of of IN cord-005453-4057qib7 11664 9 CD4 CD4 NNP cord-005453-4057qib7 11664 10 + + CC cord-005453-4057qib7 11664 11 T T NNP cord-005453-4057qib7 11664 12 cells cell NNS cord-005453-4057qib7 11664 13 into into IN cord-005453-4057qib7 11664 14 Th1 th1 NN cord-005453-4057qib7 11664 15 , , , cord-005453-4057qib7 11664 16 Th2 th2 CD cord-005453-4057qib7 11664 17 , , , cord-005453-4057qib7 11664 18 Th17 Th17 NNP cord-005453-4057qib7 11665 1 cells cell NNS cord-005453-4057qib7 11665 2 or or CC cord-005453-4057qib7 11665 3 Treg Treg NNP cord-005453-4057qib7 11665 4 cells cell NNS cord-005453-4057qib7 11665 5 was be VBD cord-005453-4057qib7 11665 6 found find VBN cord-005453-4057qib7 11665 7 . . . cord-005453-4057qib7 11666 1 In in IN cord-005453-4057qib7 11666 2 ATG ATG NNP cord-005453-4057qib7 11666 3 - - HYPH cord-005453-4057qib7 11666 4 treated treat VBN cord-005453-4057qib7 11666 5 patients patient NNS cord-005453-4057qib7 11666 6 , , , cord-005453-4057qib7 11666 7 IL-7 IL-7 NNP cord-005453-4057qib7 11666 8 and and CC cord-005453-4057qib7 11666 9 IL-15 IL-15 NNP cord-005453-4057qib7 11666 10 levels level NNS cord-005453-4057qib7 11666 11 at at IN cord-005453-4057qib7 11666 12 day day NN cord-005453-4057qib7 11666 13 +14 +14 CD cord-005453-4057qib7 11666 14 were be VBD cord-005453-4057qib7 11666 15 significantly significantly RB cord-005453-4057qib7 11666 16 lower low JJR cord-005453-4057qib7 11666 17 in in IN cord-005453-4057qib7 11666 18 patients patient NNS cord-005453-4057qib7 11666 19 developing develop VBG cord-005453-4057qib7 11666 20 acute acute JJ cord-005453-4057qib7 11666 21 GvHD GvHD NNP cord-005453-4057qib7 11666 22 grade grade NN cord-005453-4057qib7 11666 23 II II NNP cord-005453-4057qib7 11666 24 - - HYPH cord-005453-4057qib7 11666 25 IV IV NNP cord-005453-4057qib7 11666 26 ( ( -LRB- cord-005453-4057qib7 11666 27 P=0.0007 P=0.0007 NNP cord-005453-4057qib7 11666 28 and and CC cord-005453-4057qib7 11666 29 P=0.0007 P=0.0007 NNP cord-005453-4057qib7 11666 30 , , , cord-005453-4057qib7 11666 31 respectively respectively RB cord-005453-4057qib7 11666 32 ) ) -RRB- cord-005453-4057qib7 11666 33 . . . cord-005453-4057qib7 11667 1 In in IN cord-005453-4057qib7 11667 2 the the DT cord-005453-4057qib7 11667 3 total total JJ cord-005453-4057qib7 11667 4 cohort cohort NN cord-005453-4057qib7 11667 5 , , , cord-005453-4057qib7 11667 6 increased increase VBD cord-005453-4057qib7 11667 7 IL-7 IL-7 NNP cord-005453-4057qib7 11667 8 levels level NNS cord-005453-4057qib7 11667 9 were be VBD cord-005453-4057qib7 11667 10 associated associate VBN cord-005453-4057qib7 11667 11 with with IN cord-005453-4057qib7 11667 12 a a DT cord-005453-4057qib7 11667 13 reactivation reactivation NN cord-005453-4057qib7 11667 14 of of IN cord-005453-4057qib7 11667 15 EBV EBV NNP cord-005453-4057qib7 11667 16 ( ( -LRB- cord-005453-4057qib7 11667 17 P=0.040 P=0.040 NNP cord-005453-4057qib7 11667 18 ) ) -RRB- cord-005453-4057qib7 11667 19 . . . cord-005453-4057qib7 11668 1 Conclusions conclusion NNS cord-005453-4057qib7 11668 2 : : : cord-005453-4057qib7 11669 1 These these DT cord-005453-4057qib7 11669 2 findings finding NNS cord-005453-4057qib7 11669 3 suggest suggest VBP cord-005453-4057qib7 11669 4 that that IN cord-005453-4057qib7 11669 5 quantification quantification NN cord-005453-4057qib7 11669 6 of of IN cord-005453-4057qib7 11669 7 IL-7 IL-7 NNP cord-005453-4057qib7 11669 8 and and CC cord-005453-4057qib7 11669 9 IL-15 IL-15 NNP cord-005453-4057qib7 11669 10 can can MD cord-005453-4057qib7 11669 11 be be VB cord-005453-4057qib7 11669 12 indicative indicative JJ cord-005453-4057qib7 11669 13 for for IN cord-005453-4057qib7 11669 14 the the DT cord-005453-4057qib7 11669 15 degree degree NN cord-005453-4057qib7 11669 16 of of IN cord-005453-4057qib7 11669 17 T t NN cord-005453-4057qib7 11669 18 - - HYPH cord-005453-4057qib7 11669 19 cell cell NN cord-005453-4057qib7 11669 20 depletion depletion NN cord-005453-4057qib7 11669 21 during during IN cord-005453-4057qib7 11669 22 the the DT cord-005453-4057qib7 11669 23 first first JJ cord-005453-4057qib7 11669 24 weeks week NNS cord-005453-4057qib7 11669 25 after after IN cord-005453-4057qib7 11669 26 HSCT HSCT NNP cord-005453-4057qib7 11669 27 and and CC cord-005453-4057qib7 11669 28 predictive predictive JJ cord-005453-4057qib7 11669 29 of of IN cord-005453-4057qib7 11669 30 complications complication NNS cord-005453-4057qib7 11669 31 . . . cord-005453-4057qib7 11670 1 Overall overall RB cord-005453-4057qib7 11670 2 , , , cord-005453-4057qib7 11670 3 these these DT cord-005453-4057qib7 11670 4 results result NNS cord-005453-4057qib7 11670 5 indicate indicate VBP cord-005453-4057qib7 11670 6 that that IN cord-005453-4057qib7 11670 7 the the DT cord-005453-4057qib7 11670 8 lymphopenia lymphopenia NNP cord-005453-4057qib7 11670 9 - - HYPH cord-005453-4057qib7 11670 10 induced induce VBN cord-005453-4057qib7 11670 11 elevation elevation NN cord-005453-4057qib7 11670 12 of of IN cord-005453-4057qib7 11670 13 IL-7 IL-7 NNP cord-005453-4057qib7 11670 14 and and CC cord-005453-4057qib7 11670 15 IL-15 IL-15 NNP cord-005453-4057qib7 11670 16 is be VBZ cord-005453-4057qib7 11670 17 a a DT cord-005453-4057qib7 11670 18 major major JJ cord-005453-4057qib7 11670 19 driver driver NN cord-005453-4057qib7 11670 20 of of IN cord-005453-4057qib7 11670 21 the the DT cord-005453-4057qib7 11670 22 initial initial JJ cord-005453-4057qib7 11670 23 expansion expansion NN cord-005453-4057qib7 11670 24 of of IN cord-005453-4057qib7 11670 25 donor donor NN cord-005453-4057qib7 11670 26 T t NN cord-005453-4057qib7 11670 27 - - HYPH cord-005453-4057qib7 11670 28 cells cell NNS cord-005453-4057qib7 11670 29 . . . cord-005453-4057qib7 11671 1 Background background NN cord-005453-4057qib7 11671 2 : : : cord-005453-4057qib7 11672 1 Mathematical mathematical JJ cord-005453-4057qib7 11672 2 kinetic kinetic JJ cord-005453-4057qib7 11672 3 models model NNS cord-005453-4057qib7 11672 4 were be VBD cord-005453-4057qib7 11672 5 adopted adopt VBN cord-005453-4057qib7 11672 6 to to TO cord-005453-4057qib7 11672 7 study study VB cord-005453-4057qib7 11672 8 immune immune JJ cord-005453-4057qib7 11672 9 cell cell NN cord-005453-4057qib7 11672 10 reconstitution reconstitution NN cord-005453-4057qib7 11672 11 after after IN cord-005453-4057qib7 11672 12 allogeneic allogeneic JJ cord-005453-4057qib7 11672 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 11672 14 stem stem NN cord-005453-4057qib7 11672 15 cell cell NN cord-005453-4057qib7 11672 16 transplantation transplantation NN cord-005453-4057qib7 11672 17 ( ( -LRB- cord-005453-4057qib7 11672 18 allo allo NN cord-005453-4057qib7 11672 19 - - HYPH cord-005453-4057qib7 11672 20 HSCT HSCT NNP cord-005453-4057qib7 11672 21 ) ) -RRB- cord-005453-4057qib7 11672 22 . . . cord-005453-4057qib7 11673 1 The the DT cord-005453-4057qib7 11673 2 associations association NNS cord-005453-4057qib7 11673 3 between between IN cord-005453-4057qib7 11673 4 acute acute JJ cord-005453-4057qib7 11673 5 graft graft NN cord-005453-4057qib7 11673 6 - - HYPH cord-005453-4057qib7 11673 7 versus versus IN cord-005453-4057qib7 11673 8 - - HYPH cord-005453-4057qib7 11673 9 host host NN cord-005453-4057qib7 11673 10 disease disease NN cord-005453-4057qib7 11673 11 ( ( -LRB- cord-005453-4057qib7 11673 12 aGVHD aGVHD NNP cord-005453-4057qib7 11673 13 ) ) -RRB- cord-005453-4057qib7 11673 14 , , , cord-005453-4057qib7 11673 15 relapse relapse NN cord-005453-4057qib7 11673 16 and and CC cord-005453-4057qib7 11673 17 the the DT cord-005453-4057qib7 11673 18 immune immune JJ cord-005453-4057qib7 11673 19 cell cell NN cord-005453-4057qib7 11673 20 reconstitution reconstitution NN cord-005453-4057qib7 11673 21 kinetic kinetic JJ cord-005453-4057qib7 11673 22 models model NNS cord-005453-4057qib7 11673 23 were be VBD cord-005453-4057qib7 11673 24 explored explore VBN cord-005453-4057qib7 11673 25 . . . cord-005453-4057qib7 11674 1 Methods method NNS cord-005453-4057qib7 11674 2 : : : cord-005453-4057qib7 11674 3 From from IN cord-005453-4057qib7 11674 4 June June NNP cord-005453-4057qib7 11674 5 1 1 CD cord-005453-4057qib7 11674 6 , , , cord-005453-4057qib7 11674 7 2011 2011 CD cord-005453-4057qib7 11674 8 to to IN cord-005453-4057qib7 11674 9 May May NNP cord-005453-4057qib7 11674 10 31 31 CD cord-005453-4057qib7 11674 11 , , , cord-005453-4057qib7 11674 12 2015 2015 CD cord-005453-4057qib7 11674 13 , , , cord-005453-4057qib7 11674 14 sixty sixty CD cord-005453-4057qib7 11674 15 - - HYPH cord-005453-4057qib7 11674 16 five five CD cord-005453-4057qib7 11674 17 patients patient NNS cord-005453-4057qib7 11674 18 with with IN cord-005453-4057qib7 11674 19 hematological hematological JJ cord-005453-4057qib7 11674 20 malignancies malignancy NNS cord-005453-4057qib7 11674 21 after after IN cord-005453-4057qib7 11674 22 allo allo NN cord-005453-4057qib7 11674 23 - - HYPH cord-005453-4057qib7 11674 24 HSCT HSCT NNP cord-005453-4057qib7 11674 25 were be VBD cord-005453-4057qib7 11674 26 recruited recruit VBN cord-005453-4057qib7 11674 27 . . . cord-005453-4057qib7 11675 1 Peripheral peripheral JJ cord-005453-4057qib7 11675 2 blood blood NN cord-005453-4057qib7 11675 3 was be VBD cord-005453-4057qib7 11675 4 collected collect VBN cord-005453-4057qib7 11675 5 on on IN cord-005453-4057qib7 11675 6 +14 +14 CD cord-005453-4057qib7 11675 7 day day NN cord-005453-4057qib7 11675 8 , , , cord-005453-4057qib7 11675 9 +28 +28 NNP cord-005453-4057qib7 11675 10 day day NN cord-005453-4057qib7 11675 11 , , , cord-005453-4057qib7 11675 12 +42 +42 NNP cord-005453-4057qib7 11675 13 day day NN cord-005453-4057qib7 11675 14 and and CC cord-005453-4057qib7 11675 15 in in IN cord-005453-4057qib7 11675 16 +2 +2 CD cord-005453-4057qib7 11675 17 month month NN cord-005453-4057qib7 11675 18 , , , cord-005453-4057qib7 11675 19 +3 +3 NNP cord-005453-4057qib7 11675 20 month month NN cord-005453-4057qib7 11675 21 , , , cord-005453-4057qib7 11675 22 +6 +6 CD cord-005453-4057qib7 11675 23 month month NN cord-005453-4057qib7 11675 24 , , , cord-005453-4057qib7 11675 25 +9 +9 CD cord-005453-4057qib7 11675 26 month month NN cord-005453-4057qib7 11675 27 , , , cord-005453-4057qib7 11676 1 +12 +12 CD cord-005453-4057qib7 11676 2 month month NN cord-005453-4057qib7 11676 3 , , , cord-005453-4057qib7 11676 4 +18 +18 CD cord-005453-4057qib7 11676 5 month month NN cord-005453-4057qib7 11676 6 , , , cord-005453-4057qib7 11677 1 +24 +24 NNP cord-005453-4057qib7 11677 2 month month NN cord-005453-4057qib7 11677 3 . . . cord-005453-4057qib7 11678 1 Lymphocyte lymphocyte NN cord-005453-4057qib7 11678 2 subsets subset NNS cord-005453-4057qib7 11678 3 were be VBD cord-005453-4057qib7 11678 4 determined determine VBN cord-005453-4057qib7 11678 5 by by IN cord-005453-4057qib7 11678 6 flow flow NN cord-005453-4057qib7 11678 7 cytometry cytometry NN cord-005453-4057qib7 11678 8 , , , cord-005453-4057qib7 11678 9 including include VBG cord-005453-4057qib7 11678 10 in in IN cord-005453-4057qib7 11678 11 total total JJ cord-005453-4057qib7 11678 12 T t NN cord-005453-4057qib7 11678 13 lymphocytes lymphocyte NNS cord-005453-4057qib7 11678 14 ( ( -LRB- cord-005453-4057qib7 11678 15 CD3 CD3 NNP cord-005453-4057qib7 11678 16 + + SYM cord-005453-4057qib7 11678 17 ) ) -RRB- cord-005453-4057qib7 11678 18 , , , cord-005453-4057qib7 11678 19 helper helper NN cord-005453-4057qib7 11678 20 T t NN cord-005453-4057qib7 11678 21 cells cell NNS cord-005453-4057qib7 11678 22 ( ( -LRB- cord-005453-4057qib7 11678 23 CD3 CD3 NNP cord-005453-4057qib7 11678 24 + + CC cord-005453-4057qib7 11678 25 CD4 CD4 NNP cord-005453-4057qib7 11678 26 + + CC cord-005453-4057qib7 11678 27 ) ) -RRB- cord-005453-4057qib7 11678 28 , , , cord-005453-4057qib7 11678 29 cytotoxic cytotoxic JJ cord-005453-4057qib7 11678 30 T t NN cord-005453-4057qib7 11678 31 cells cell NNS cord-005453-4057qib7 11678 32 ( ( -LRB- cord-005453-4057qib7 11678 33 CD3 CD3 NNP cord-005453-4057qib7 11678 34 + + CC cord-005453-4057qib7 11678 35 CD8 CD8 NNP cord-005453-4057qib7 11678 36 + + SYM cord-005453-4057qib7 11678 37 ) ) -RRB- cord-005453-4057qib7 11678 38 , , , cord-005453-4057qib7 11678 39 CD4 CD4 NNP cord-005453-4057qib7 11678 40 / / SYM cord-005453-4057qib7 11678 41 CD8 CD8 NNP cord-005453-4057qib7 11678 42 ratio ratio NN cord-005453-4057qib7 11678 43 , , , cord-005453-4057qib7 11678 44 nature nature NN cord-005453-4057qib7 11678 45 killer killer NN cord-005453-4057qib7 11678 46 ( ( -LRB- cord-005453-4057qib7 11678 47 NK NK NNP cord-005453-4057qib7 11678 48 ) ) -RRB- cord-005453-4057qib7 11678 49 cells cell NNS cord-005453-4057qib7 11678 50 ( ( -LRB- cord-005453-4057qib7 11678 51 CD3 CD3 NNP cord-005453-4057qib7 11678 52 -CD56 -cd56 NN cord-005453-4057qib7 11679 1 + + LS cord-005453-4057qib7 11679 2 ) ) -RRB- cord-005453-4057qib7 11679 3 , , , cord-005453-4057qib7 11679 4 NKT NKT NNP cord-005453-4057qib7 11679 5 cells cell NNS cord-005453-4057qib7 11679 6 ( ( -LRB- cord-005453-4057qib7 11679 7 CD3 CD3 NNP cord-005453-4057qib7 11679 8 + + CC cord-005453-4057qib7 11679 9 CD56 CD56 NNP cord-005453-4057qib7 11680 1 + + LS cord-005453-4057qib7 11680 2 ) ) -RRB- cord-005453-4057qib7 11680 3 , , , cord-005453-4057qib7 11680 4 B b NN cord-005453-4057qib7 11680 5 lymphocyte lymphocyte NN cord-005453-4057qib7 11680 6 ( ( -LRB- cord-005453-4057qib7 11680 7 CD19 CD19 NNP cord-005453-4057qib7 11680 8 + + CC cord-005453-4057qib7 11680 9 ) ) -RRB- cord-005453-4057qib7 11680 10 , , , cord-005453-4057qib7 11680 11 naive naive JJ cord-005453-4057qib7 11680 12 T t NN cord-005453-4057qib7 11680 13 cells cell NNS cord-005453-4057qib7 11680 14 ( ( -LRB- cord-005453-4057qib7 11680 15 CD3 CD3 NNP cord-005453-4057qib7 11680 16 + + CC cord-005453-4057qib7 11680 17 HLA HLA NNP cord-005453-4057qib7 11680 18 - - HYPH cord-005453-4057qib7 11680 19 DR DR NNP cord-005453-4057qib7 11680 20 + + CC cord-005453-4057qib7 11680 21 ) ) -RRB- cord-005453-4057qib7 11680 22 , , , cord-005453-4057qib7 11680 23 static static JJ cord-005453-4057qib7 11680 24 T t NN cord-005453-4057qib7 11680 25 cells cell NNS cord-005453-4057qib7 11680 26 ( ( -LRB- cord-005453-4057qib7 11680 27 CD3 CD3 NNP cord-005453-4057qib7 11680 28 + + CC cord-005453-4057qib7 11680 29 HLA HLA NNP cord-005453-4057qib7 11680 30 - - HYPH cord-005453-4057qib7 11680 31 DR DR NNP cord-005453-4057qib7 11680 32 - - , cord-005453-4057qib7 11680 33 ) ) -RRB- cord-005453-4057qib7 11680 34 , , , cord-005453-4057qib7 11680 35 and and CC cord-005453-4057qib7 11680 36 regulatory regulatory JJ cord-005453-4057qib7 11680 37 T t NN cord-005453-4057qib7 11680 38 cells cell NNS cord-005453-4057qib7 11680 39 ( ( -LRB- cord-005453-4057qib7 11680 40 CD4 CD4 NNP cord-005453-4057qib7 11680 41 + + CC cord-005453-4057qib7 11681 1 CD25 cd25 JJ cord-005453-4057qib7 11681 2 high high RB cord-005453-4057qib7 11682 1 Foxp3 foxp3 JJ cord-005453-4057qib7 11682 2 + + CC cord-005453-4057qib7 11682 3 ) ) -RRB- cord-005453-4057qib7 11682 4 . . . cord-005453-4057qib7 11683 1 Mathematical mathematical JJ cord-005453-4057qib7 11683 2 kinetic kinetic JJ cord-005453-4057qib7 11683 3 models model NNS cord-005453-4057qib7 11683 4 were be VBD cord-005453-4057qib7 11683 5 calculated calculate VBN cord-005453-4057qib7 11683 6 for for IN cord-005453-4057qib7 11683 7 immune immune JJ cord-005453-4057qib7 11683 8 cell cell NN cord-005453-4057qib7 11683 9 reconstitution reconstitution NN cord-005453-4057qib7 11683 10 with with IN cord-005453-4057qib7 11683 11 SPSS SPSS NNP cord-005453-4057qib7 11683 12 . . . cord-005453-4057qib7 11684 1 Results result NNS cord-005453-4057qib7 11684 2 : : : cord-005453-4057qib7 11685 1 After after IN cord-005453-4057qib7 11685 2 allo allo NN cord-005453-4057qib7 11685 3 - - HYPH cord-005453-4057qib7 11685 4 HSCT HSCT NNP cord-005453-4057qib7 11685 5 , , , cord-005453-4057qib7 11685 6 a a DT cord-005453-4057qib7 11685 7 logarithmic logarithmic JJ cord-005453-4057qib7 11685 8 curve curve NN cord-005453-4057qib7 11685 9 model model NN cord-005453-4057qib7 11685 10 was be VBD cord-005453-4057qib7 11685 11 observed observe VBN cord-005453-4057qib7 11685 12 for for IN cord-005453-4057qib7 11685 13 CD3 CD3 NNP cord-005453-4057qib7 11685 14 + + CC cord-005453-4057qib7 11685 15 T T NNP cord-005453-4057qib7 11685 16 cells cell NNS cord-005453-4057qib7 11685 17 . . . cord-005453-4057qib7 11686 1 Cubic cubic JJ cord-005453-4057qib7 11686 2 curve curve NN cord-005453-4057qib7 11686 3 models model NNS cord-005453-4057qib7 11686 4 were be VBD cord-005453-4057qib7 11686 5 observed observe VBN cord-005453-4057qib7 11686 6 for for IN cord-005453-4057qib7 11686 7 CD3 CD3 NNP cord-005453-4057qib7 11686 8 + + SYM cord-005453-4057qib7 11686 9 CD4 CD4 NNP cord-005453-4057qib7 11686 10 + + CC cord-005453-4057qib7 11686 11 T t NN cord-005453-4057qib7 11686 12 cells cell NNS cord-005453-4057qib7 11686 13 , , , cord-005453-4057qib7 11686 14 CD4 CD4 NNP cord-005453-4057qib7 11686 15 + + CC cord-005453-4057qib7 11687 1 CD25 CD25 NNP cord-005453-4057qib7 11688 1 high+ high+ NNP cord-005453-4057qib7 11688 2 Foxp3 Foxp3 NNP cord-005453-4057qib7 11688 3 + + CC cord-005453-4057qib7 11688 4 T T NNP cord-005453-4057qib7 11688 5 cell cell NN cord-005453-4057qib7 11688 6 , , , cord-005453-4057qib7 11688 7 CD3 CD3 NNP cord-005453-4057qib7 11688 8 + + CC cord-005453-4057qib7 11688 9 HLA HLA NNP cord-005453-4057qib7 11688 10 - - HYPH cord-005453-4057qib7 11688 11 DR DR NNP cord-005453-4057qib7 11688 12 -T -T : cord-005453-4057qib7 11688 13 cells cell NNS cord-005453-4057qib7 11688 14 , , , cord-005453-4057qib7 11688 15 CD3 CD3 NNP cord-005453-4057qib7 11688 16 + + CC cord-005453-4057qib7 11688 17 CD56 CD56 NNP cord-005453-4057qib7 11688 18 + + SYM cord-005453-4057qib7 11688 19 NKT NKT NNP cord-005453-4057qib7 11688 20 cells cell NNS cord-005453-4057qib7 11688 21 , , , cord-005453-4057qib7 11688 22 CD19 CD19 NNP cord-005453-4057qib7 11688 23 + + CC cord-005453-4057qib7 11688 24 B b NN cord-005453-4057qib7 11688 25 cells cell NNS cord-005453-4057qib7 11688 26 . . . cord-005453-4057qib7 11689 1 CD3 CD3 NNP cord-005453-4057qib7 11689 2 + + CC cord-005453-4057qib7 11689 3 CD8 CD8 NNP cord-005453-4057qib7 11689 4 + + CC cord-005453-4057qib7 11689 5 T T NNP cord-005453-4057qib7 11689 6 cells cell NNS cord-005453-4057qib7 11689 7 , , , cord-005453-4057qib7 11689 8 CD3 CD3 NNP cord-005453-4057qib7 11689 9 + + CC cord-005453-4057qib7 11689 10 HLA HLA NNP cord-005453-4057qib7 11689 11 - - HYPH cord-005453-4057qib7 11689 12 DR DR NNP cord-005453-4057qib7 11689 13 + + CC cord-005453-4057qib7 11689 14 T t NN cord-005453-4057qib7 11689 15 cells cell NNS cord-005453-4057qib7 11689 16 , , , cord-005453-4057qib7 11689 17 and and CC cord-005453-4057qib7 11689 18 CD3 CD3 NNP cord-005453-4057qib7 11689 19 -CD56 -cd56 NN cord-005453-4057qib7 11690 1 + + CC cord-005453-4057qib7 11691 1 NK NK NNP cord-005453-4057qib7 11691 2 cells cell NNS cord-005453-4057qib7 11691 3 showed show VBD cord-005453-4057qib7 11691 4 S s NN cord-005453-4057qib7 11691 5 type type NN cord-005453-4057qib7 11691 6 curve curve NN cord-005453-4057qib7 11691 7 models model NNS cord-005453-4057qib7 11691 8 . . . cord-005453-4057qib7 11692 1 Considering consider VBG cord-005453-4057qib7 11692 2 T t NN cord-005453-4057qib7 11692 3 cells cell NNS cord-005453-4057qib7 11692 4 were be VBD cord-005453-4057qib7 11692 5 the the DT cord-005453-4057qib7 11692 6 major major JJ cord-005453-4057qib7 11692 7 mediators mediator NNS cord-005453-4057qib7 11692 8 for for IN cord-005453-4057qib7 11692 9 aGVHD aGVHD NNP cord-005453-4057qib7 11692 10 and and CC cord-005453-4057qib7 11692 11 graft graft NN cord-005453-4057qib7 11692 12 - - HYPH cord-005453-4057qib7 11692 13 versusleukemia versusleukemia NN cord-005453-4057qib7 11692 14 effect effect NN cord-005453-4057qib7 11692 15 after after IN cord-005453-4057qib7 11692 16 allo allo NN cord-005453-4057qib7 11692 17 - - HYPH cord-005453-4057qib7 11692 18 HSCT HSCT NNP cord-005453-4057qib7 11692 19 . . . cord-005453-4057qib7 11693 1 With with IN cord-005453-4057qib7 11693 2 established establish VBN cord-005453-4057qib7 11693 3 immune immune JJ cord-005453-4057qib7 11693 4 cell cell NN cord-005453-4057qib7 11693 5 kinetic kinetic JJ cord-005453-4057qib7 11693 6 models model NNS cord-005453-4057qib7 11693 7 , , , cord-005453-4057qib7 11693 8 we -PRON- PRP cord-005453-4057qib7 11693 9 found find VBD cord-005453-4057qib7 11693 10 that that IN cord-005453-4057qib7 11693 11 different different JJ cord-005453-4057qib7 11693 12 curve curve NN cord-005453-4057qib7 11693 13 models model NNS cord-005453-4057qib7 11693 14 were be VBD cord-005453-4057qib7 11693 15 observed observe VBN cord-005453-4057qib7 11693 16 between between IN cord-005453-4057qib7 11693 17 patients patient NNS cord-005453-4057qib7 11693 18 with with IN cord-005453-4057qib7 11693 19 and and CC cord-005453-4057qib7 11693 20 without without IN cord-005453-4057qib7 11693 21 aGVHD agvhd NN cord-005453-4057qib7 11693 22 after after IN cord-005453-4057qib7 11693 23 allo allo NN cord-005453-4057qib7 11693 24 - - HYPH cord-005453-4057qib7 11693 25 HSCT HSCT NNP cord-005453-4057qib7 11693 26 . . . cord-005453-4057qib7 11694 1 Although although IN cord-005453-4057qib7 11694 2 the the DT cord-005453-4057qib7 11694 3 kinetic kinetic JJ cord-005453-4057qib7 11694 4 models model NNS cord-005453-4057qib7 11694 5 were be VBD cord-005453-4057qib7 11694 6 almost almost RB cord-005453-4057qib7 11694 7 the the DT cord-005453-4057qib7 11694 8 same same JJ cord-005453-4057qib7 11694 9 for for IN cord-005453-4057qib7 11694 10 leukemia leukemia NN cord-005453-4057qib7 11694 11 - - HYPH cord-005453-4057qib7 11694 12 free free JJ cord-005453-4057qib7 11694 13 and and CC cord-005453-4057qib7 11694 14 relapsed relapsed JJ cord-005453-4057qib7 11694 15 patients patient NNS cord-005453-4057qib7 11694 16 in in IN cord-005453-4057qib7 11694 17 the the DT cord-005453-4057qib7 11694 18 first first JJ cord-005453-4057qib7 11694 19 3 3 CD cord-005453-4057qib7 11694 20 months month NNS cord-005453-4057qib7 11694 21 after after IN cord-005453-4057qib7 11694 22 allo allo NN cord-005453-4057qib7 11694 23 - - HYPH cord-005453-4057qib7 11694 24 HSCT HSCT NNP cord-005453-4057qib7 11694 25 , , , cord-005453-4057qib7 11694 26 significantly significantly RB cord-005453-4057qib7 11694 27 different different JJ cord-005453-4057qib7 11694 28 kinetic kinetic JJ cord-005453-4057qib7 11694 29 curves curve NNS cord-005453-4057qib7 11694 30 could could MD cord-005453-4057qib7 11694 31 be be VB cord-005453-4057qib7 11694 32 observed observe VBN cord-005453-4057qib7 11694 33 thereafter thereafter RB cord-005453-4057qib7 11694 34 . . . cord-005453-4057qib7 11695 1 Conclusions conclusion NNS cord-005453-4057qib7 11695 2 : : : cord-005453-4057qib7 11696 1 The the DT cord-005453-4057qib7 11696 2 immune immune JJ cord-005453-4057qib7 11696 3 cell cell NN cord-005453-4057qib7 11696 4 reconstitution reconstitution NN cord-005453-4057qib7 11696 5 showed show VBD cord-005453-4057qib7 11696 6 different different JJ cord-005453-4057qib7 11696 7 mathematical mathematical JJ cord-005453-4057qib7 11696 8 curve curve NN cord-005453-4057qib7 11696 9 models model NNS cord-005453-4057qib7 11696 10 after after IN cord-005453-4057qib7 11696 11 allo allo NN cord-005453-4057qib7 11696 12 - - HYPH cord-005453-4057qib7 11696 13 HSCT HSCT NNP cord-005453-4057qib7 11696 14 . . . cord-005453-4057qib7 11697 1 Kinetic kinetic JJ cord-005453-4057qib7 11697 2 reconstitution reconstitution NN cord-005453-4057qib7 11697 3 model model NN cord-005453-4057qib7 11697 4 of of IN cord-005453-4057qib7 11697 5 certain certain JJ cord-005453-4057qib7 11697 6 immune immune JJ cord-005453-4057qib7 11697 7 cell cell NN cord-005453-4057qib7 11697 8 was be VBD cord-005453-4057qib7 11697 9 associated associate VBN cord-005453-4057qib7 11697 10 with with IN cord-005453-4057qib7 11697 11 aGVHD agvhd NN cord-005453-4057qib7 11697 12 and and CC cord-005453-4057qib7 11697 13 relapse relapse NN cord-005453-4057qib7 11697 14 . . . cord-005453-4057qib7 11698 1 Hence hence RB cord-005453-4057qib7 11698 2 , , , cord-005453-4057qib7 11698 3 mathematical mathematical JJ cord-005453-4057qib7 11698 4 kinetic kinetic JJ cord-005453-4057qib7 11698 5 models model NNS cord-005453-4057qib7 11698 6 of of IN cord-005453-4057qib7 11698 7 immune immune JJ cord-005453-4057qib7 11698 8 cell cell NN cord-005453-4057qib7 11698 9 reconstitution reconstitution NN cord-005453-4057qib7 11698 10 may may MD cord-005453-4057qib7 11698 11 be be VB cord-005453-4057qib7 11698 12 potential potential JJ cord-005453-4057qib7 11698 13 indictor indictor NN cord-005453-4057qib7 11698 14 for for IN cord-005453-4057qib7 11698 15 predicting predict VBG cord-005453-4057qib7 11698 16 aGVHD agvhd NN cord-005453-4057qib7 11698 17 and and CC cord-005453-4057qib7 11698 18 relapse relapse VB cord-005453-4057qib7 11698 19 after after IN cord-005453-4057qib7 11698 20 allo allo NN cord-005453-4057qib7 11698 21 - - HYPH cord-005453-4057qib7 11698 22 HSCT HSCT NNP cord-005453-4057qib7 11698 23 . . . cord-005453-4057qib7 11699 1 Disclosure disclosure NN cord-005453-4057qib7 11699 2 : : : cord-005453-4057qib7 11699 3 Nothing nothing NN cord-005453-4057qib7 11699 4 to to TO cord-005453-4057qib7 11699 5 declare declare VB cord-005453-4057qib7 11699 6 Lineage Lineage NNP cord-005453-4057qib7 11699 7 specific specific JJ cord-005453-4057qib7 11699 8 chimerism chimerism NN cord-005453-4057qib7 11699 9 analysis analysis NN cord-005453-4057qib7 11699 10 in in IN cord-005453-4057qib7 11699 11 pediatric pediatric JJ cord-005453-4057qib7 11699 12 patients patient NNS cord-005453-4057qib7 11699 13 following follow VBG cord-005453-4057qib7 11699 14 allogeneic allogeneic IN cord-005453-4057qib7 11699 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 11699 16 cell cell NN cord-005453-4057qib7 11699 17 transplantation transplantation NN cord-005453-4057qib7 11699 18 ( ( -LRB- cord-005453-4057qib7 11699 19 HCT HCT NNP cord-005453-4057qib7 11699 20 Background background NN cord-005453-4057qib7 11699 21 : : : cord-005453-4057qib7 11700 1 The the DT cord-005453-4057qib7 11700 2 outcome outcome NN cord-005453-4057qib7 11700 3 of of IN cord-005453-4057qib7 11700 4 allogeneic allogeneic NN cord-005453-4057qib7 11700 5 HCT hct NN cord-005453-4057qib7 11700 6 is be VBZ cord-005453-4057qib7 11700 7 dependent dependent JJ cord-005453-4057qib7 11700 8 on on IN cord-005453-4057qib7 11700 9 several several JJ cord-005453-4057qib7 11700 10 variables variable NNS cord-005453-4057qib7 11700 11 that that WDT cord-005453-4057qib7 11700 12 include include VBP cord-005453-4057qib7 11700 13 patient patient JJ cord-005453-4057qib7 11700 14 age age NN cord-005453-4057qib7 11700 15 , , , cord-005453-4057qib7 11700 16 disease disease NN cord-005453-4057qib7 11700 17 and and CC cord-005453-4057qib7 11700 18 stage stage NN cord-005453-4057qib7 11700 19 , , , cord-005453-4057qib7 11700 20 cytoreduction cytoreduction NN cord-005453-4057qib7 11700 21 , , , cord-005453-4057qib7 11700 22 graft graft NN cord-005453-4057qib7 11700 23 , , , cord-005453-4057qib7 11700 24 graft graft NN cord-005453-4057qib7 11700 25 manipulation manipulation NN cord-005453-4057qib7 11700 26 , , , cord-005453-4057qib7 11700 27 and and CC cord-005453-4057qib7 11700 28 graft graft NN cord-005453-4057qib7 11700 29 versus versus IN cord-005453-4057qib7 11700 30 host host NN cord-005453-4057qib7 11700 31 disease disease NN cord-005453-4057qib7 11700 32 ( ( -LRB- cord-005453-4057qib7 11700 33 GvHD GvHD NNP cord-005453-4057qib7 11700 34 ) ) -RRB- cord-005453-4057qib7 11700 35 prophylaxis prophylaxis NN cord-005453-4057qib7 11700 36 . . . cord-005453-4057qib7 11701 1 One one CD cord-005453-4057qib7 11701 2 aspect aspect NN cord-005453-4057qib7 11701 3 of of IN cord-005453-4057qib7 11701 4 HCT hct NN cord-005453-4057qib7 11701 5 that that WDT cord-005453-4057qib7 11701 6 remains remain VBZ cord-005453-4057qib7 11701 7 poorly poorly RB cord-005453-4057qib7 11701 8 defined define VBN cord-005453-4057qib7 11701 9 and and CC cord-005453-4057qib7 11701 10 studied study VBN cord-005453-4057qib7 11701 11 is be VBZ cord-005453-4057qib7 11701 12 the the DT cord-005453-4057qib7 11701 13 donor/ donor/ CD cord-005453-4057qib7 11701 14 host host NN cord-005453-4057qib7 11701 15 ( ( -LRB- cord-005453-4057qib7 11701 16 D d NN cord-005453-4057qib7 11701 17 / / SYM cord-005453-4057qib7 11701 18 H h NN cord-005453-4057qib7 11701 19 ) ) -RRB- cord-005453-4057qib7 11701 20 chimerism chimerism NN cord-005453-4057qib7 11701 21 post post NN cord-005453-4057qib7 11701 22 HCT hct NN cord-005453-4057qib7 11701 23 . . . cord-005453-4057qib7 11702 1 Since since IN cord-005453-4057qib7 11702 2 2010 2010 CD cord-005453-4057qib7 11702 3 , , , cord-005453-4057qib7 11702 4 we -PRON- PRP cord-005453-4057qib7 11702 5 followed follow VBD cord-005453-4057qib7 11702 6 patients patient NNS cord-005453-4057qib7 11702 7 with with IN cord-005453-4057qib7 11702 8 D D NNP cord-005453-4057qib7 11702 9 / / SYM cord-005453-4057qib7 11702 10 H h NN cord-005453-4057qib7 11702 11 lineage lineage NN cord-005453-4057qib7 11702 12 specific specific JJ cord-005453-4057qib7 11702 13 chimerism chimerism NN cord-005453-4057qib7 11702 14 post post NN cord-005453-4057qib7 11702 15 HCT hct NN cord-005453-4057qib7 11702 16 . . . cord-005453-4057qib7 11703 1 Analyses analysis NNS cord-005453-4057qib7 11703 2 were be VBD cord-005453-4057qib7 11703 3 performed perform VBN cord-005453-4057qib7 11703 4 by by IN cord-005453-4057qib7 11703 5 short short JJ cord-005453-4057qib7 11703 6 tandem tandem NN cord-005453-4057qib7 11703 7 repeat repeat NN cord-005453-4057qib7 11703 8 ( ( -LRB- cord-005453-4057qib7 11704 1 STR STR NNP cord-005453-4057qib7 11704 2 ) ) -RRB- cord-005453-4057qib7 11704 3 polymorphism polymorphism NN cord-005453-4057qib7 11704 4 analysis analysis NN cord-005453-4057qib7 11704 5 at at IN cord-005453-4057qib7 11704 6 the the DT cord-005453-4057qib7 11704 7 American American NNP cord-005453-4057qib7 11704 8 Red Red NNP cord-005453-4057qib7 11704 9 Cross Cross NNP cord-005453-4057qib7 11704 10 Blood Blood NNP cord-005453-4057qib7 11704 11 Services Services NNP cord-005453-4057qib7 11704 12 ( ( -LRB- cord-005453-4057qib7 11704 13 Philadelphia Philadelphia NNP cord-005453-4057qib7 11704 14 , , , cord-005453-4057qib7 11704 15 PA PA NNP cord-005453-4057qib7 11704 16 ) ) -RRB- cord-005453-4057qib7 11704 17 . . . cord-005453-4057qib7 11705 1 Studies study NNS cord-005453-4057qib7 11705 2 were be VBD cord-005453-4057qib7 11705 3 performed perform VBN cord-005453-4057qib7 11705 4 on on IN cord-005453-4057qib7 11705 5 blood blood NN cord-005453-4057qib7 11705 6 total total JJ cord-005453-4057qib7 11705 7 leukocytes leukocyte NNS cord-005453-4057qib7 11705 8 , , , cord-005453-4057qib7 11705 9 myeloid myeloid NN cord-005453-4057qib7 11705 10 / / SYM cord-005453-4057qib7 11705 11 neutrophil neutrophil NN cord-005453-4057qib7 11705 12 Cells cell NNS cord-005453-4057qib7 11705 13 , , , cord-005453-4057qib7 11705 14 T t NN cord-005453-4057qib7 11705 15 - - HYPH cord-005453-4057qib7 11705 16 cells cell NNS cord-005453-4057qib7 11705 17 , , , cord-005453-4057qib7 11705 18 Bcells Bcells NNP cord-005453-4057qib7 11705 19 , , , cord-005453-4057qib7 11705 20 and and CC cord-005453-4057qib7 11705 21 NK nk NN cord-005453-4057qib7 11705 22 - - HYPH cord-005453-4057qib7 11705 23 cells cell NNS cord-005453-4057qib7 11705 24 . . . cord-005453-4057qib7 11706 1 Methods method NNS cord-005453-4057qib7 11706 2 : : : cord-005453-4057qib7 11706 3 In in IN cord-005453-4057qib7 11706 4 this this DT cord-005453-4057qib7 11706 5 retrospective retrospective JJ cord-005453-4057qib7 11706 6 study study NN cord-005453-4057qib7 11706 7 , , , cord-005453-4057qib7 11706 8 the the DT cord-005453-4057qib7 11706 9 charts chart NNS cord-005453-4057qib7 11706 10 of of IN cord-005453-4057qib7 11706 11 154 154 CD cord-005453-4057qib7 11706 12 consecutive consecutive JJ cord-005453-4057qib7 11706 13 patients patient NNS cord-005453-4057qib7 11706 14 who who WP cord-005453-4057qib7 11706 15 underwent undergo VBD cord-005453-4057qib7 11706 16 allogeneic allogeneic JJ cord-005453-4057qib7 11706 17 HCT hct NN cord-005453-4057qib7 11706 18 between between IN cord-005453-4057qib7 11706 19 January January NNP cord-005453-4057qib7 11706 20 2010 2010 CD cord-005453-4057qib7 11706 21 to to IN cord-005453-4057qib7 11706 22 June June NNP cord-005453-4057qib7 11706 23 2015 2015 CD cord-005453-4057qib7 11706 24 on on IN cord-005453-4057qib7 11706 25 the the DT cord-005453-4057qib7 11706 26 Pediatric Pediatric NNP cord-005453-4057qib7 11706 27 Bone Bone NNP cord-005453-4057qib7 11706 28 Marrow Marrow NNP cord-005453-4057qib7 11706 29 Transplant Transplant NNP cord-005453-4057qib7 11706 30 Service Service NNP cord-005453-4057qib7 11706 31 at at IN cord-005453-4057qib7 11706 32 MSKCC MSKCC NNS cord-005453-4057qib7 11706 33 were be VBD cord-005453-4057qib7 11706 34 retrospectively retrospectively RB cord-005453-4057qib7 11706 35 reviewed review VBN cord-005453-4057qib7 11706 36 . . . cord-005453-4057qib7 11707 1 Lineage lineage NN cord-005453-4057qib7 11707 2 specific specific JJ cord-005453-4057qib7 11707 3 donor donor NN cord-005453-4057qib7 11707 4 chimerism chimerism NN cord-005453-4057qib7 11707 5 post post NN cord-005453-4057qib7 11707 6 HCT HCT NNP cord-005453-4057qib7 11707 7 was be VBD cord-005453-4057qib7 11707 8 studied study VBN cord-005453-4057qib7 11707 9 including include VBG cord-005453-4057qib7 11707 10 D d NN cord-005453-4057qib7 11707 11 / / SYM cord-005453-4057qib7 11707 12 H h NN cord-005453-4057qib7 11707 13 chimerism chimerism NN cord-005453-4057qib7 11707 14 trend trend NN cord-005453-4057qib7 11707 15 , , , cord-005453-4057qib7 11707 16 and and CC cord-005453-4057qib7 11707 17 factors factor NNS cord-005453-4057qib7 11707 18 with with IN cord-005453-4057qib7 11707 19 potential potential JJ cord-005453-4057qib7 11707 20 impact impact NN cord-005453-4057qib7 11707 21 on on IN cord-005453-4057qib7 11707 22 chimerism chimerism NN cord-005453-4057qib7 11707 23 including include VBG cord-005453-4057qib7 11707 24 : : : cord-005453-4057qib7 11707 25 age age NN cord-005453-4057qib7 11707 26 , , , cord-005453-4057qib7 11707 27 disease disease NN cord-005453-4057qib7 11707 28 , , , cord-005453-4057qib7 11707 29 graft graft NN cord-005453-4057qib7 11707 30 source source NN cord-005453-4057qib7 11707 31 , , , cord-005453-4057qib7 11707 32 and and CC cord-005453-4057qib7 11707 33 T t NN cord-005453-4057qib7 11707 34 - - HYPH cord-005453-4057qib7 11707 35 cell cell NN cord-005453-4057qib7 11707 36 depletion depletion NN cord-005453-4057qib7 11707 37 ( ( -LRB- cord-005453-4057qib7 11707 38 TCD TCD NNP cord-005453-4057qib7 11707 39 ) ) -RRB- cord-005453-4057qib7 11707 40 . . . cord-005453-4057qib7 11708 1 Preliminary preliminary JJ cord-005453-4057qib7 11708 2 analyzes analyze VBZ cord-005453-4057qib7 11708 3 performed perform VBN cord-005453-4057qib7 11708 4 on on IN cord-005453-4057qib7 11708 5 this this DT cord-005453-4057qib7 11708 6 cohort cohort NN cord-005453-4057qib7 11708 7 included include VBD cord-005453-4057qib7 11708 8 Wilcoxon Wilcoxon NNP cord-005453-4057qib7 11708 9 Rank Rank NNP cord-005453-4057qib7 11708 10 Test Test NNP cord-005453-4057qib7 11708 11 and and CC cord-005453-4057qib7 11708 12 cox cox NNP cord-005453-4057qib7 11708 13 proportional proportional JJ cord-005453-4057qib7 11708 14 hazard hazard NN cord-005453-4057qib7 11708 15 analyses analysis NNS cord-005453-4057qib7 11708 16 . . . cord-005453-4057qib7 11709 1 Results result NNS cord-005453-4057qib7 11709 2 : : : cord-005453-4057qib7 11709 3 137 137 CD cord-005453-4057qib7 11709 4 patients patient NNS cord-005453-4057qib7 11709 5 were be VBD cord-005453-4057qib7 11709 6 selected select VBN cord-005453-4057qib7 11709 7 based base VBN cord-005453-4057qib7 11709 8 on on IN cord-005453-4057qib7 11709 9 the the DT cord-005453-4057qib7 11709 10 number number NN cord-005453-4057qib7 11709 11 of of IN cord-005453-4057qib7 11709 12 analyses analysis NNS cord-005453-4057qib7 11709 13 . . . cord-005453-4057qib7 11710 1 The the DT cord-005453-4057qib7 11710 2 median median JJ cord-005453-4057qib7 11710 3 age age NN cord-005453-4057qib7 11710 4 was be VBD cord-005453-4057qib7 11710 5 11.3 11.3 CD cord-005453-4057qib7 11710 6 years year NNS cord-005453-4057qib7 11710 7 . . . cord-005453-4057qib7 11711 1 Patients patient NNS cord-005453-4057qib7 11711 2 had have VBD cord-005453-4057qib7 11711 3 hematologic hematologic JJ cord-005453-4057qib7 11711 4 malignancies malignancy NNS cord-005453-4057qib7 11711 5 ( ( -LRB- cord-005453-4057qib7 11711 6 N=95 N=95 NNP cord-005453-4057qib7 11711 7 ) ) -RRB- cord-005453-4057qib7 11711 8 or or CC cord-005453-4057qib7 11711 9 non non JJ cord-005453-4057qib7 11711 10 - - JJ cord-005453-4057qib7 11711 11 malignant malignant JJ cord-005453-4057qib7 11711 12 hematologic hematologic JJ cord-005453-4057qib7 11711 13 diseases disease NNS cord-005453-4057qib7 11711 14 ( ( -LRB- cord-005453-4057qib7 11711 15 N=27 N=27 NNP cord-005453-4057qib7 11711 16 ) ) -RRB- cord-005453-4057qib7 11711 17 , , , cord-005453-4057qib7 11711 18 or or CC cord-005453-4057qib7 11711 19 immune immune JJ cord-005453-4057qib7 11711 20 disorders disorder NNS cord-005453-4057qib7 11711 21 ( ( -LRB- cord-005453-4057qib7 11711 22 N=15 N=15 NNP cord-005453-4057qib7 11711 23 ) ) -RRB- cord-005453-4057qib7 11711 24 . . . cord-005453-4057qib7 11712 1 Cytoreduction Cytoreduction NNP cord-005453-4057qib7 11712 2 included include VBD cord-005453-4057qib7 11712 3 TBI-(N=42 TBI-(N=42 NNP cord-005453-4057qib7 11712 4 ) ) -RRB- cord-005453-4057qib7 11712 5 , , , cord-005453-4057qib7 11712 6 or or CC cord-005453-4057qib7 11712 7 chemotherapybased chemotherapybase VBN cord-005453-4057qib7 11712 8 regiments regiment NNS cord-005453-4057qib7 11712 9 ( ( -LRB- cord-005453-4057qib7 11712 10 N=98 N=98 NNP cord-005453-4057qib7 11712 11 ) ) -RRB- cord-005453-4057qib7 11712 12 . . . cord-005453-4057qib7 11713 1 Patients patient NNS cord-005453-4057qib7 11713 2 were be VBD cord-005453-4057qib7 11713 3 recipients recipient NNS cord-005453-4057qib7 11713 4 of of IN cord-005453-4057qib7 11713 5 T t NN cord-005453-4057qib7 11713 6 - - HYPH cord-005453-4057qib7 11713 7 cell cell NN cord-005453-4057qib7 11713 8 depleted deplete VBN cord-005453-4057qib7 11713 9 marrow marrow NN cord-005453-4057qib7 11713 10 or or CC cord-005453-4057qib7 11713 11 peripheral peripheral JJ cord-005453-4057qib7 11713 12 blood blood NN cord-005453-4057qib7 11713 13 grafts graft NNS cord-005453-4057qib7 11713 14 ( ( -LRB- cord-005453-4057qib7 11713 15 N=101 N=101 NNP cord-005453-4057qib7 11713 16 ) ) -RRB- cord-005453-4057qib7 11713 17 , , , cord-005453-4057qib7 11713 18 unmodified unmodified JJ cord-005453-4057qib7 11713 19 marrow marrow NN cord-005453-4057qib7 11713 20 or or CC cord-005453-4057qib7 11713 21 peripheral peripheral JJ cord-005453-4057qib7 11713 22 blood blood NN cord-005453-4057qib7 11713 23 grafts graft NNS cord-005453-4057qib7 11713 24 ( ( -LRB- cord-005453-4057qib7 11713 25 N=28 N=28 NNP cord-005453-4057qib7 11713 26 ) ) -RRB- cord-005453-4057qib7 11713 27 or or CC cord-005453-4057qib7 11713 28 cord cord NN cord-005453-4057qib7 11713 29 blood blood NN cord-005453-4057qib7 11713 30 grafts graft NNS cord-005453-4057qib7 11713 31 ( ( -LRB- cord-005453-4057qib7 11713 32 N=8 N=8 NNP cord-005453-4057qib7 11713 33 ) ) -RRB- cord-005453-4057qib7 11713 34 . . . cord-005453-4057qib7 11714 1 Full full JJ cord-005453-4057qib7 11714 2 donor donor NN cord-005453-4057qib7 11714 3 chimerism chimerism NN cord-005453-4057qib7 11714 4 of of IN cord-005453-4057qib7 11714 5 myeloid myeloid NN cord-005453-4057qib7 11714 6 cells cell NNS cord-005453-4057qib7 11714 7 , , , cord-005453-4057qib7 11714 8 B b NN cord-005453-4057qib7 11714 9 - - HYPH cord-005453-4057qib7 11714 10 cells cell NNS cord-005453-4057qib7 11714 11 and and CC cord-005453-4057qib7 11714 12 NKcells nkcell NNS cord-005453-4057qib7 11714 13 , , , cord-005453-4057qib7 11714 14 but but CC cord-005453-4057qib7 11714 15 not not RB cord-005453-4057qib7 11714 16 T t NN cord-005453-4057qib7 11714 17 - - HYPH cord-005453-4057qib7 11714 18 cells cell NNS cord-005453-4057qib7 11714 19 occurred occur VBD cord-005453-4057qib7 11714 20 early early JJ cord-005453-4057qib7 11714 21 post post NN cord-005453-4057qib7 11714 22 - - NN cord-005453-4057qib7 11714 23 transplant transplant NN cord-005453-4057qib7 11714 24 . . . cord-005453-4057qib7 11715 1 There there EX cord-005453-4057qib7 11715 2 was be VBD cord-005453-4057qib7 11715 3 no no DT cord-005453-4057qib7 11715 4 difference difference NN cord-005453-4057qib7 11715 5 in in IN cord-005453-4057qib7 11715 6 the the DT cord-005453-4057qib7 11715 7 percentage percentage NN cord-005453-4057qib7 11715 8 of of IN cord-005453-4057qib7 11715 9 total total JJ cord-005453-4057qib7 11715 10 donor donor NN cord-005453-4057qib7 11715 11 leukocytes leukocyte NNS cord-005453-4057qib7 11715 12 at at IN cord-005453-4057qib7 11715 13 3 3 CD cord-005453-4057qib7 11715 14 months month NNS cord-005453-4057qib7 11715 15 vs. vs. IN cord-005453-4057qib7 11715 16 12 12 CD cord-005453-4057qib7 11715 17 months month NNS cord-005453-4057qib7 11716 1 post post NNP cord-005453-4057qib7 11716 2 HSCT HSCT NNP cord-005453-4057qib7 11716 3 ( ( -LRB- cord-005453-4057qib7 11716 4 n=30 n=30 NNP cord-005453-4057qib7 11716 5 ) ) -RRB- cord-005453-4057qib7 11716 6 , , , cord-005453-4057qib7 11716 7 while while IN cord-005453-4057qib7 11716 8 the the DT cord-005453-4057qib7 11716 9 median median NN cord-005453-4057qib7 11716 10 of of IN cord-005453-4057qib7 11716 11 donor donor NN cord-005453-4057qib7 11716 12 T t NN cord-005453-4057qib7 11716 13 - - HYPH cord-005453-4057qib7 11716 14 cell cell NN cord-005453-4057qib7 11716 15 chimerism chimerism NN cord-005453-4057qib7 11716 16 was be VBD cord-005453-4057qib7 11716 17 51 51 CD cord-005453-4057qib7 11716 18 % % NN cord-005453-4057qib7 11716 19 at at IN cord-005453-4057qib7 11716 20 3 3 CD cord-005453-4057qib7 11716 21 months month NNS cord-005453-4057qib7 11716 22 and and CC cord-005453-4057qib7 11716 23 91 91 CD cord-005453-4057qib7 11716 24 % % NN cord-005453-4057qib7 11716 25 at at IN cord-005453-4057qib7 11716 26 12 12 CD cord-005453-4057qib7 11716 27 months month NNS cord-005453-4057qib7 11717 1 post post NNP cord-005453-4057qib7 11717 2 HSCT HSCT NNP cord-005453-4057qib7 11717 3 ( ( -LRB- cord-005453-4057qib7 11717 4 p p NN cord-005453-4057qib7 11717 5 < < XX cord-005453-4057qib7 11717 6 0.0001 0.0001 CD cord-005453-4057qib7 11717 7 , , , cord-005453-4057qib7 11717 8 N=42 N=42 NNP cord-005453-4057qib7 11717 9 ) ) -RRB- cord-005453-4057qib7 11717 10 . . . cord-005453-4057qib7 11718 1 Figure figure NN cord-005453-4057qib7 11718 2 1 1 CD cord-005453-4057qib7 11718 3 shows show VBZ cord-005453-4057qib7 11718 4 the the DT cord-005453-4057qib7 11718 5 impact impact NN cord-005453-4057qib7 11718 6 of of IN cord-005453-4057qib7 11718 7 different different JJ cord-005453-4057qib7 11718 8 factors factor NNS cord-005453-4057qib7 11718 9 including include VBG cord-005453-4057qib7 11718 10 : : : cord-005453-4057qib7 11718 11 ( ( -LRB- cord-005453-4057qib7 11718 12 A a NN cord-005453-4057qib7 11718 13 ) ) -RRB- cord-005453-4057qib7 11718 14 the the DT cord-005453-4057qib7 11718 15 use use NN cord-005453-4057qib7 11718 16 of of IN cord-005453-4057qib7 11718 17 TBI TBI NNP cord-005453-4057qib7 11718 18 - - : cord-005453-4057qib7 11718 19 or or CC cord-005453-4057qib7 11718 20 chemotherapy chemotherapy NN cord-005453-4057qib7 11718 21 - - HYPH cord-005453-4057qib7 11718 22 based base VBN cord-005453-4057qib7 11718 23 regimens regimen NNS cord-005453-4057qib7 11718 24 , , , cord-005453-4057qib7 11718 25 ( ( -LRB- cord-005453-4057qib7 11718 26 B b NN cord-005453-4057qib7 11718 27 ) ) -RRB- cord-005453-4057qib7 11718 28 age age NN cord-005453-4057qib7 11718 29 ( ( -LRB- cord-005453-4057qib7 11718 30 < < XX cord-005453-4057qib7 11718 31 or or CC cord-005453-4057qib7 11718 32 > > XX cord-005453-4057qib7 11718 33 3 3 CD cord-005453-4057qib7 11718 34 years year NNS cord-005453-4057qib7 11718 35 ) ) -RRB- cord-005453-4057qib7 11718 36 , , , cord-005453-4057qib7 11718 37 and and CC cord-005453-4057qib7 11718 38 ( ( -LRB- cord-005453-4057qib7 11718 39 C c NN cord-005453-4057qib7 11718 40 ) ) -RRB- cord-005453-4057qib7 11718 41 type type NN cord-005453-4057qib7 11718 42 of of IN cord-005453-4057qib7 11718 43 graft graft NN cord-005453-4057qib7 11718 44 ( ( -LRB- cord-005453-4057qib7 11718 45 T t NN cord-005453-4057qib7 11718 46 - - HYPH cord-005453-4057qib7 11718 47 cell cell NN cord-005453-4057qib7 11718 48 depleted deplete VBN cord-005453-4057qib7 11718 49 Vs Vs NNP cord-005453-4057qib7 11718 50 unmodified unmodified JJ cord-005453-4057qib7 11718 51 Vs Vs NNP cord-005453-4057qib7 11718 52 Cord Cord NNP cord-005453-4057qib7 11718 53 Blood blood NN cord-005453-4057qib7 11718 54 ) ) -RRB- cord-005453-4057qib7 11718 55 . . . cord-005453-4057qib7 11719 1 Donor donor NN cord-005453-4057qib7 11719 2 total total JJ cord-005453-4057qib7 11719 3 leukocytes leukocyte NNS cord-005453-4057qib7 11719 4 chimerism chimerism NN cord-005453-4057qib7 11719 5 was be VBD cord-005453-4057qib7 11719 6 significantly significantly RB cord-005453-4057qib7 11719 7 lower low JJR cord-005453-4057qib7 11719 8 at at IN cord-005453-4057qib7 11719 9 12 12 CD cord-005453-4057qib7 11719 10 months month NNS cord-005453-4057qib7 11719 11 as as IN cord-005453-4057qib7 11719 12 compared compare VBN cord-005453-4057qib7 11719 13 to to IN cord-005453-4057qib7 11719 14 3 3 CD cord-005453-4057qib7 11719 15 months month NNS cord-005453-4057qib7 11719 16 for for IN cord-005453-4057qib7 11719 17 patients patient NNS cord-005453-4057qib7 11719 18 < < XX cord-005453-4057qib7 11719 19 3 3 CD cord-005453-4057qib7 11719 20 years year NNS cord-005453-4057qib7 11719 21 of of IN cord-005453-4057qib7 11719 22 age age NN cord-005453-4057qib7 11719 23 ( ( -LRB- cord-005453-4057qib7 11719 24 p=0.012 p=0.012 NNP cord-005453-4057qib7 11719 25 ) ) -RRB- cord-005453-4057qib7 11719 26 . . . cord-005453-4057qib7 11720 1 For for IN cord-005453-4057qib7 11720 2 most most JJS cord-005453-4057qib7 11720 3 grafts graft NNS cord-005453-4057qib7 11720 4 , , , cord-005453-4057qib7 11720 5 full full JJ cord-005453-4057qib7 11720 6 donor donor NN cord-005453-4057qib7 11720 7 chimerism chimerism NN cord-005453-4057qib7 11720 8 of of IN cord-005453-4057qib7 11720 9 T t NN cord-005453-4057qib7 11720 10 - - HYPH cord-005453-4057qib7 11720 11 cells cell NNS cord-005453-4057qib7 11720 12 occurred occur VBD cord-005453-4057qib7 11720 13 early early RB cord-005453-4057qib7 11720 14 , , , cord-005453-4057qib7 11720 15 while while IN cord-005453-4057qib7 11720 16 for for IN cord-005453-4057qib7 11720 17 T t NN cord-005453-4057qib7 11720 18 - - HYPH cord-005453-4057qib7 11720 19 cell cell NN cord-005453-4057qib7 11720 20 depleted deplete VBN cord-005453-4057qib7 11720 21 transplants transplant NNS cord-005453-4057qib7 11720 22 , , , cord-005453-4057qib7 11720 23 it -PRON- PRP cord-005453-4057qib7 11720 24 took take VBD cord-005453-4057qib7 11720 25 up up RP cord-005453-4057qib7 11720 26 to to IN cord-005453-4057qib7 11720 27 one one CD cord-005453-4057qib7 11720 28 year year NN cord-005453-4057qib7 11720 29 to to TO cord-005453-4057qib7 11720 30 complete complete VB cord-005453-4057qib7 11720 31 . . . cord-005453-4057qib7 11721 1 Cord cord NN cord-005453-4057qib7 11721 2 blood blood NN cord-005453-4057qib7 11721 3 grafts graft NNS cord-005453-4057qib7 11721 4 were be VBD cord-005453-4057qib7 11721 5 associated associate VBN cord-005453-4057qib7 11721 6 with with IN cord-005453-4057qib7 11721 7 high high JJ cord-005453-4057qib7 11721 8 T t NN cord-005453-4057qib7 11721 9 - - HYPH cord-005453-4057qib7 11721 10 cell cell NN cord-005453-4057qib7 11721 11 donor donor NN cord-005453-4057qib7 11721 12 chimerism chimerism NN cord-005453-4057qib7 11721 13 throughout throughout IN cord-005453-4057qib7 11721 14 the the DT cord-005453-4057qib7 11721 15 post post JJ cord-005453-4057qib7 11721 16 - - JJ cord-005453-4057qib7 11721 17 transplant transplant JJ cord-005453-4057qib7 11721 18 period period NN cord-005453-4057qib7 11721 19 . . . cord-005453-4057qib7 11722 1 There there EX cord-005453-4057qib7 11722 2 was be VBD cord-005453-4057qib7 11722 3 a a DT cord-005453-4057qib7 11722 4 significant significant JJ cord-005453-4057qib7 11722 5 difference difference NN cord-005453-4057qib7 11722 6 in in IN cord-005453-4057qib7 11722 7 the the DT cord-005453-4057qib7 11722 8 % % NN cord-005453-4057qib7 11722 9 donor donor NN cord-005453-4057qib7 11722 10 T t NN cord-005453-4057qib7 11722 11 - - HYPH cord-005453-4057qib7 11722 12 cells cell NNS cord-005453-4057qib7 11722 13 at at IN cord-005453-4057qib7 11722 14 3 3 CD cord-005453-4057qib7 11722 15 and and CC cord-005453-4057qib7 11722 16 12 12 CD cord-005453-4057qib7 11722 17 months month NNS cord-005453-4057qib7 11722 18 post post NN cord-005453-4057qib7 11722 19 HCT hct NN cord-005453-4057qib7 11722 20 when when WRB cord-005453-4057qib7 11722 21 comparing compare VBG cord-005453-4057qib7 11722 22 T t NN cord-005453-4057qib7 11722 23 - - HYPH cord-005453-4057qib7 11722 24 cell cell NN cord-005453-4057qib7 11722 25 depleted deplete VBN cord-005453-4057qib7 11722 26 and and CC cord-005453-4057qib7 11722 27 unmodified unmodified JJ cord-005453-4057qib7 11722 28 grafts graft NNS cord-005453-4057qib7 11722 29 ( ( -LRB- cord-005453-4057qib7 11722 30 p=0.015 p=0.015 NNP cord-005453-4057qib7 11722 31 ) ) -RRB- cord-005453-4057qib7 11722 32 . . . cord-005453-4057qib7 11723 1 Conclusions conclusion NNS cord-005453-4057qib7 11723 2 : : : cord-005453-4057qib7 11724 1 This this DT cord-005453-4057qib7 11724 2 preliminary preliminary JJ cord-005453-4057qib7 11724 3 analysis analysis NN cord-005453-4057qib7 11724 4 of of IN cord-005453-4057qib7 11724 5 lineage lineage NN cord-005453-4057qib7 11724 6 specific specific JJ cord-005453-4057qib7 11724 7 chimerism chimerism NN cord-005453-4057qib7 11724 8 post post JJ cord-005453-4057qib7 11724 9 - - JJ cord-005453-4057qib7 11724 10 transplant transplant NN cord-005453-4057qib7 11724 11 showed show VBD cord-005453-4057qib7 11724 12 that that IN cord-005453-4057qib7 11724 13 donor donor NN cord-005453-4057qib7 11724 14 Tcells Tcells NNP cord-005453-4057qib7 11724 15 may may MD cord-005453-4057qib7 11724 16 take take VB cord-005453-4057qib7 11724 17 one one CD cord-005453-4057qib7 11724 18 year year NN cord-005453-4057qib7 11724 19 to to TO cord-005453-4057qib7 11724 20 fully fully RB cord-005453-4057qib7 11724 21 recover recover VB cord-005453-4057qib7 11724 22 post post NN cord-005453-4057qib7 11724 23 - - JJ cord-005453-4057qib7 11724 24 transplant transplant NN cord-005453-4057qib7 11724 25 , , , cord-005453-4057qib7 11724 26 mostly mostly RB cord-005453-4057qib7 11724 27 following follow VBG cord-005453-4057qib7 11724 28 T t NN cord-005453-4057qib7 11724 29 - - HYPH cord-005453-4057qib7 11724 30 cell cell NN cord-005453-4057qib7 11724 31 depleted deplete VBN cord-005453-4057qib7 11724 32 grafts graft NNS cord-005453-4057qib7 11724 33 , , , cord-005453-4057qib7 11724 34 without without IN cord-005453-4057qib7 11724 35 intervention intervention NN cord-005453-4057qib7 11724 36 . . . cord-005453-4057qib7 11725 1 Cord cord NN cord-005453-4057qib7 11725 2 blood blood NN cord-005453-4057qib7 11725 3 grafts graft NNS cord-005453-4057qib7 11725 4 were be VBD cord-005453-4057qib7 11725 5 associated associate VBN cord-005453-4057qib7 11725 6 with with IN cord-005453-4057qib7 11725 7 high high JJ cord-005453-4057qib7 11725 8 donor donor NN cord-005453-4057qib7 11725 9 chimerism chimerism NN cord-005453-4057qib7 11725 10 throughout throughout IN cord-005453-4057qib7 11725 11 the the DT cord-005453-4057qib7 11725 12 post post JJ cord-005453-4057qib7 11725 13 - - JJ cord-005453-4057qib7 11725 14 transplant transplant JJ cord-005453-4057qib7 11725 15 period period NN cord-005453-4057qib7 11725 16 . . . cord-005453-4057qib7 11726 1 Lastly lastly RB cord-005453-4057qib7 11726 2 , , , cord-005453-4057qib7 11726 3 factors factor NNS cord-005453-4057qib7 11726 4 associated associate VBN cord-005453-4057qib7 11726 5 with with IN cord-005453-4057qib7 11726 6 loss loss NN cord-005453-4057qib7 11726 7 of of IN cord-005453-4057qib7 11726 8 donor donor NN cord-005453-4057qib7 11726 9 chimerism chimerism NN cord-005453-4057qib7 11726 10 posttransplant posttransplant NN cord-005453-4057qib7 11726 11 were be VBD cord-005453-4057qib7 11726 12 younger young JJR cord-005453-4057qib7 11726 13 age age NN cord-005453-4057qib7 11726 14 and and CC cord-005453-4057qib7 11726 15 non non JJ cord-005453-4057qib7 11726 16 - - JJ cord-005453-4057qib7 11726 17 malignant malignant JJ cord-005453-4057qib7 11726 18 disorders disorder NNS cord-005453-4057qib7 11726 19 . . . cord-005453-4057qib7 11727 1 More More JJR cord-005453-4057qib7 11727 2 in in IN cord-005453-4057qib7 11727 3 - - HYPH cord-005453-4057qib7 11727 4 depth depth NN cord-005453-4057qib7 11727 5 analyses analysis NNS cord-005453-4057qib7 11727 6 are be VBP cord-005453-4057qib7 11727 7 being be VBG cord-005453-4057qib7 11727 8 performed perform VBN cord-005453-4057qib7 11727 9 including include VBG cord-005453-4057qib7 11727 10 the the DT cord-005453-4057qib7 11727 11 relation relation NN cord-005453-4057qib7 11727 12 of of IN cord-005453-4057qib7 11727 13 chimerism chimerism NN cord-005453-4057qib7 11727 14 and and CC cord-005453-4057qib7 11727 15 HCT hct NN cord-005453-4057qib7 11727 16 outcome outcome NN cord-005453-4057qib7 11727 17 . . . cord-005453-4057qib7 11728 1 Disclosure disclosure NN cord-005453-4057qib7 11728 2 : : : cord-005453-4057qib7 11729 1 Eileen Eileen NNP cord-005453-4057qib7 11729 2 Nicoletti Nicoletti NNP cord-005453-4057qib7 11730 1 -Employee -Employee NNP cord-005453-4057qib7 11730 2 Rocket Rocket NNP cord-005453-4057qib7 11730 3 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 11730 4 , , , cord-005453-4057qib7 11730 5 Susan Susan NNP cord-005453-4057qib7 11730 6 Prockop Prockop NNP cord-005453-4057qib7 11731 1 -Investigator -Investigator NNP cord-005453-4057qib7 11732 1 Atara Atara NNP cord-005453-4057qib7 11732 2 Biotherapeutics Biotherapeutics NNPS cord-005453-4057qib7 11732 3 -Research -Research : cord-005453-4057qib7 11732 4 funding funding NN cord-005453-4057qib7 11732 5 , , , cord-005453-4057qib7 11732 6 Susan Susan NNP cord-005453-4057qib7 11732 7 Prockop Prockop NNP cord-005453-4057qib7 11733 1 -Mesoblast -mesoblast RB cord-005453-4057qib7 11734 1 -Research -Research : cord-005453-4057qib7 11734 2 funding funding NN cord-005453-4057qib7 11734 3 , , , cord-005453-4057qib7 11734 4 Nancy Nancy NNP cord-005453-4057qib7 11734 5 Kernan Kernan NNP cord-005453-4057qib7 11735 1 -Gentium -gentium LS cord-005453-4057qib7 11735 2 -support -support XX cord-005453-4057qib7 11735 3 ; ; : cord-005453-4057qib7 11735 4 Jazz Jazz NNP cord-005453-4057qib7 11735 5 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 11735 6 -Support -Support NNP cord-005453-4057qib7 11735 7 , , , cord-005453-4057qib7 11735 8 Richard Richard NNP cord-005453-4057qib7 11735 9 O´Reilly o´reilly RB cord-005453-4057qib7 11735 10 -Atara -Atara . cord-005453-4057qib7 11735 11 Biotherapeutics Biotherapeutics NNPS cord-005453-4057qib7 11735 12 -Royalty -royalty RB cord-005453-4057qib7 11735 13 , , , cord-005453-4057qib7 11735 14 Consultancy Consultancy NNP cord-005453-4057qib7 11735 15 and and CC cord-005453-4057qib7 11735 16 Research Research NNP cord-005453-4057qib7 11735 17 , , , cord-005453-4057qib7 11736 1 Jaap Jaap NNP cord-005453-4057qib7 11736 2 Jan Jan NNP cord-005453-4057qib7 11736 3 Boelens Boelens NNP cord-005453-4057qib7 11736 4 -Bluebird -Bluebird VBZ cord-005453-4057qib7 11736 5 Bio Bio NNP cord-005453-4057qib7 11737 1 -Consultancy -Consultancy NNP cord-005453-4057qib7 11737 2 , , , cord-005453-4057qib7 11737 3 Avrobio Avrobio NNP cord-005453-4057qib7 11737 4 -Consultancy -Consultancy NNP cord-005453-4057qib7 11738 1 ; ; : cord-005453-4057qib7 11738 2 Jaap Jaap NNP cord-005453-4057qib7 11738 3 Jan Jan NNP cord-005453-4057qib7 11738 4 Boelens Boelens NNP cord-005453-4057qib7 11739 1 -Chimerix -Chimerix . cord-005453-4057qib7 11740 1 -Consultancy -Consultancy NNP cord-005453-4057qib7 11741 1 ; ; : cord-005453-4057qib7 11741 2 Magenta Magenta NNP cord-005453-4057qib7 11741 3 -Consultancy -Consultancy NNP cord-005453-4057qib7 11741 4 Background Background NNP cord-005453-4057qib7 11741 5 : : : cord-005453-4057qib7 11742 1 The the DT cord-005453-4057qib7 11742 2 success success NN cord-005453-4057qib7 11742 3 of of IN cord-005453-4057qib7 11742 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 11742 5 stem stem NN cord-005453-4057qib7 11742 6 cell cell NN cord-005453-4057qib7 11742 7 transplantation transplantation NN cord-005453-4057qib7 11742 8 ( ( -LRB- cord-005453-4057qib7 11742 9 HSCT HSCT NNP cord-005453-4057qib7 11742 10 ) ) -RRB- cord-005453-4057qib7 11742 11 lies lie VBZ cord-005453-4057qib7 11742 12 with with IN cord-005453-4057qib7 11742 13 the the DT cord-005453-4057qib7 11742 14 ability ability NN cord-005453-4057qib7 11742 15 of of IN cord-005453-4057qib7 11742 16 the the DT cord-005453-4057qib7 11742 17 engrafted engraft VBN cord-005453-4057qib7 11742 18 immune immune JJ cord-005453-4057qib7 11742 19 system system NN cord-005453-4057qib7 11742 20 to to TO cord-005453-4057qib7 11742 21 remove remove VB cord-005453-4057qib7 11742 22 residual residual JJ cord-005453-4057qib7 11742 23 leukemia leukemia NN cord-005453-4057qib7 11742 24 cells cell NNS cord-005453-4057qib7 11742 25 via via IN cord-005453-4057qib7 11742 26 a a DT cord-005453-4057qib7 11742 27 graft graft NN cord-005453-4057qib7 11742 28 - - HYPH cord-005453-4057qib7 11742 29 versus versus IN cord-005453-4057qib7 11742 30 - - HYPH cord-005453-4057qib7 11742 31 leukemia leukemia NN cord-005453-4057qib7 11742 32 effect effect NN cord-005453-4057qib7 11742 33 . . . cord-005453-4057qib7 11743 1 Despite despite IN cord-005453-4057qib7 11743 2 this this DT cord-005453-4057qib7 11743 3 , , , cord-005453-4057qib7 11743 4 relapse relapse NN cord-005453-4057qib7 11743 5 remains remain VBZ cord-005453-4057qib7 11743 6 the the DT cord-005453-4057qib7 11743 7 major major JJ cord-005453-4057qib7 11743 8 cause cause NN cord-005453-4057qib7 11743 9 of of IN cord-005453-4057qib7 11743 10 mortality mortality NN cord-005453-4057qib7 11743 11 among among IN cord-005453-4057qib7 11743 12 patients patient NNS cord-005453-4057qib7 11743 13 receiving receive VBG cord-005453-4057qib7 11743 14 HSCT HSCT NNP cord-005453-4057qib7 11743 15 . . . cord-005453-4057qib7 11744 1 One one CD cord-005453-4057qib7 11744 2 of of IN cord-005453-4057qib7 11744 3 the the DT cord-005453-4057qib7 11744 4 immune immune JJ cord-005453-4057qib7 11744 5 evasion evasion NN cord-005453-4057qib7 11744 6 mechanisms mechanism NNS cord-005453-4057qib7 11744 7 of of IN cord-005453-4057qib7 11744 8 leukemic leukemic JJ cord-005453-4057qib7 11744 9 cells cell NNS cord-005453-4057qib7 11744 10 to to TO cord-005453-4057qib7 11744 11 escape escape VB cord-005453-4057qib7 11744 12 from from IN cord-005453-4057qib7 11744 13 donor donor NN cord-005453-4057qib7 11744 14 T t NN cord-005453-4057qib7 11744 15 cell cell NN cord-005453-4057qib7 11744 16 recognition recognition NN cord-005453-4057qib7 11744 17 in in IN cord-005453-4057qib7 11744 18 haplo haplo NNP cord-005453-4057qib7 11744 19 - - HYPH cord-005453-4057qib7 11744 20 HSCT HSCT NNP cord-005453-4057qib7 11744 21 is be VBZ cord-005453-4057qib7 11744 22 the the DT cord-005453-4057qib7 11744 23 genomic genomic JJ cord-005453-4057qib7 11744 24 loss loss NN cord-005453-4057qib7 11744 25 of of IN cord-005453-4057qib7 11744 26 the the DT cord-005453-4057qib7 11744 27 patient patient JJ cord-005453-4057qib7 11744 28 specific specific JJ cord-005453-4057qib7 11744 29 HLA HLA NNP cord-005453-4057qib7 11744 30 . . . cord-005453-4057qib7 11745 1 It -PRON- PRP cord-005453-4057qib7 11745 2 has have VBZ cord-005453-4057qib7 11745 3 been be VBN cord-005453-4057qib7 11745 4 described describe VBN cord-005453-4057qib7 11745 5 in in IN cord-005453-4057qib7 11745 6 20 20 CD cord-005453-4057qib7 11745 7 - - SYM cord-005453-4057qib7 11745 8 30 30 CD cord-005453-4057qib7 11745 9 % % NN cord-005453-4057qib7 11745 10 of of IN cord-005453-4057qib7 11745 11 acute acute JJ cord-005453-4057qib7 11745 12 myeloid myeloid NN cord-005453-4057qib7 11745 13 leukemia leukemia NN cord-005453-4057qib7 11745 14 ( ( -LRB- cord-005453-4057qib7 11745 15 AML AML NNP cord-005453-4057qib7 11745 16 ) ) -RRB- cord-005453-4057qib7 11745 17 and and CC cord-005453-4057qib7 11745 18 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 11745 19 syndrome syndrome NN cord-005453-4057qib7 11745 20 ( ( -LRB- cord-005453-4057qib7 11745 21 MDS MDS NNP cord-005453-4057qib7 11745 22 ) ) -RRB- cord-005453-4057qib7 11745 23 relapses relapse NNS cord-005453-4057qib7 11745 24 after after IN cord-005453-4057qib7 11745 25 haplo haplo NN cord-005453-4057qib7 11745 26 - - HYPH cord-005453-4057qib7 11745 27 HSCT HSCT NNP cord-005453-4057qib7 11745 28 . . . cord-005453-4057qib7 11746 1 The the DT cord-005453-4057qib7 11746 2 aim aim NN cord-005453-4057qib7 11746 3 of of IN cord-005453-4057qib7 11746 4 this this DT cord-005453-4057qib7 11746 5 study study NN cord-005453-4057qib7 11746 6 was be VBD cord-005453-4057qib7 11746 7 to to TO cord-005453-4057qib7 11746 8 analyze analyze VB cord-005453-4057qib7 11746 9 HLA HLA NNP cord-005453-4057qib7 11746 10 loss loss NN cord-005453-4057qib7 11746 11 in in IN cord-005453-4057qib7 11746 12 a a DT cord-005453-4057qib7 11746 13 large large JJ cord-005453-4057qib7 11746 14 cohort cohort NN cord-005453-4057qib7 11746 15 of of IN cord-005453-4057qib7 11746 16 patients patient NNS cord-005453-4057qib7 11746 17 who who WP cord-005453-4057qib7 11746 18 relapsed relapse VBD cord-005453-4057qib7 11746 19 after after IN cord-005453-4057qib7 11746 20 T t NN cord-005453-4057qib7 11746 21 - - HYPH cord-005453-4057qib7 11746 22 cell cell NN cord-005453-4057qib7 11746 23 replete replete JJ cord-005453-4057qib7 11746 24 haploidentical haploidentical JJ cord-005453-4057qib7 11746 25 transplantation transplantation NN cord-005453-4057qib7 11746 26 with with IN cord-005453-4057qib7 11746 27 posttransplant posttransplant NN cord-005453-4057qib7 11746 28 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 11746 29 . . . cord-005453-4057qib7 11747 1 Methods method NNS cord-005453-4057qib7 11747 2 : : : cord-005453-4057qib7 11748 1 From from IN cord-005453-4057qib7 11748 2 December December NNP cord-005453-4057qib7 11748 3 2007 2007 CD cord-005453-4057qib7 11748 4 to to IN cord-005453-4057qib7 11748 5 September September NNP cord-005453-4057qib7 11748 6 2018 2018 CD cord-005453-4057qib7 11748 7 , , , cord-005453-4057qib7 11748 8 180 180 CD cord-005453-4057qib7 11748 9 patients patient NNS cord-005453-4057qib7 11748 10 with with IN cord-005453-4057qib7 11748 11 hematological hematological JJ cord-005453-4057qib7 11748 12 malignancies malignancy NNS cord-005453-4057qib7 11748 13 who who WP cord-005453-4057qib7 11748 14 received receive VBD cord-005453-4057qib7 11748 15 a a DT cord-005453-4057qib7 11748 16 haplo haplo NN cord-005453-4057qib7 11748 17 - - HYPH cord-005453-4057qib7 11748 18 HSCT HSCT NNP cord-005453-4057qib7 11748 19 were be VBD cord-005453-4057qib7 11748 20 recruited recruit VBN cord-005453-4057qib7 11748 21 . . . cord-005453-4057qib7 11749 1 Among among IN cord-005453-4057qib7 11749 2 them -PRON- PRP cord-005453-4057qib7 11749 3 , , , cord-005453-4057qib7 11749 4 31 31 CD cord-005453-4057qib7 11749 5 patients patient NNS cord-005453-4057qib7 11749 6 presented present VBD cord-005453-4057qib7 11749 7 a a DT cord-005453-4057qib7 11749 8 relapse relapse NN cord-005453-4057qib7 11749 9 after after IN cord-005453-4057qib7 11749 10 haplo haplo NN cord-005453-4057qib7 11749 11 - - HYPH cord-005453-4057qib7 11749 12 HSCT HSCT NNP cord-005453-4057qib7 11749 13 . . . cord-005453-4057qib7 11750 1 HLA HLA NNP cord-005453-4057qib7 11750 2 typing typing NN cord-005453-4057qib7 11750 3 was be VBD cord-005453-4057qib7 11750 4 performed perform VBN cord-005453-4057qib7 11750 5 by by IN cord-005453-4057qib7 11750 6 real real JJ cord-005453-4057qib7 11750 7 - - HYPH cord-005453-4057qib7 11750 8 time time NN cord-005453-4057qib7 11750 9 PCR PCR NNP cord-005453-4057qib7 11750 10 using use VBG cord-005453-4057qib7 11750 11 HLA HLA NNP cord-005453-4057qib7 11750 12 - - HYPH cord-005453-4057qib7 11750 13 KMR KMR NNP cord-005453-4057qib7 11750 14 kit kit NN cord-005453-4057qib7 11750 15 ( ( -LRB- cord-005453-4057qib7 11750 16 GenDX gendx NN cord-005453-4057qib7 11750 17 , , , cord-005453-4057qib7 11750 18 Netherlands).Nine Netherlands).Nine NNP cord-005453-4057qib7 11750 19 patients patient NNS cord-005453-4057qib7 11750 20 were be VBD cord-005453-4057qib7 11750 21 excluded exclude VBN cord-005453-4057qib7 11750 22 from from IN cord-005453-4057qib7 11750 23 the the DT cord-005453-4057qib7 11750 24 analysis analysis NN cord-005453-4057qib7 11750 25 because because IN cord-005453-4057qib7 11750 26 the the DT cord-005453-4057qib7 11750 27 kit kit NN cord-005453-4057qib7 11750 28 employed employ VBN cord-005453-4057qib7 11750 29 did do VBD cord-005453-4057qib7 11750 30 not not RB cord-005453-4057qib7 11750 31 include include VB cord-005453-4057qib7 11750 32 the the DT cord-005453-4057qib7 11750 33 recipientspecific recipientspecific NNP cord-005453-4057qib7 11750 34 HLA HLA NNP cord-005453-4057qib7 11750 35 . . . cord-005453-4057qib7 11751 1 Thus thus RB cord-005453-4057qib7 11751 2 , , , cord-005453-4057qib7 11751 3 a a DT cord-005453-4057qib7 11751 4 total total NN cord-005453-4057qib7 11751 5 of of IN cord-005453-4057qib7 11751 6 22 22 CD cord-005453-4057qib7 11751 7 relapse relapse NN cord-005453-4057qib7 11751 8 cases case NNS cord-005453-4057qib7 11751 9 were be VBD cord-005453-4057qib7 11751 10 analyzed analyze VBN cord-005453-4057qib7 11751 11 . . . cord-005453-4057qib7 11752 1 The the DT cord-005453-4057qib7 11752 2 analysis analysis NN cord-005453-4057qib7 11752 3 of of IN cord-005453-4057qib7 11752 4 chimerism chimerism NN cord-005453-4057qib7 11752 5 was be VBD cord-005453-4057qib7 11752 6 carried carry VBN cord-005453-4057qib7 11752 7 out out RP cord-005453-4057qib7 11752 8 using use VBG cord-005453-4057qib7 11752 9 short short JJ cord-005453-4057qib7 11752 10 tandem tandem NN cord-005453-4057qib7 11752 11 repeat repeat NN cord-005453-4057qib7 11752 12 PCR pcr NN cord-005453-4057qib7 11752 13 amplification amplification NN cord-005453-4057qib7 11752 14 ( ( -LRB- cord-005453-4057qib7 11752 15 AmpFlSTR AmpFlSTR NNP cord-005453-4057qib7 11753 1 SGM SGM NNP cord-005453-4057qib7 11753 2 Plus Plus NNP cord-005453-4057qib7 11753 3 , , , cord-005453-4057qib7 11753 4 Thermo Thermo NNP cord-005453-4057qib7 11753 5 Fisher Fisher NNP cord-005453-4057qib7 11753 6 , , , cord-005453-4057qib7 11753 7 USA USA NNP cord-005453-4057qib7 11753 8 ) ) -RRB- cord-005453-4057qib7 11753 9 with with IN cord-005453-4057qib7 11753 10 a a DT cord-005453-4057qib7 11753 11 sensitivity sensitivity NN cord-005453-4057qib7 11753 12 of of IN cord-005453-4057qib7 11753 13 1 1 CD cord-005453-4057qib7 11753 14 % % NN cord-005453-4057qib7 11753 15 . . . cord-005453-4057qib7 11754 1 Results result NNS cord-005453-4057qib7 11754 2 : : : cord-005453-4057qib7 11755 1 Genomic genomic JJ cord-005453-4057qib7 11755 2 loss loss NN cord-005453-4057qib7 11755 3 of of IN cord-005453-4057qib7 11755 4 the the DT cord-005453-4057qib7 11755 5 patient patient NN cord-005453-4057qib7 11755 6 HLA HLA NNP cord-005453-4057qib7 11755 7 occurred occur VBD cord-005453-4057qib7 11755 8 in in IN cord-005453-4057qib7 11755 9 6/ 6/ CD cord-005453-4057qib7 11755 10 22 22 CD cord-005453-4057qib7 11755 11 patients patient NNS cord-005453-4057qib7 11755 12 ( ( -LRB- cord-005453-4057qib7 11755 13 27 27 CD cord-005453-4057qib7 11755 14 % % NN cord-005453-4057qib7 11755 15 ) ) -RRB- cord-005453-4057qib7 11756 1 ( ( -LRB- cord-005453-4057qib7 11756 2 Table table NN cord-005453-4057qib7 11756 3 1 1 CD cord-005453-4057qib7 11756 4 ) ) -RRB- cord-005453-4057qib7 11756 5 . . . cord-005453-4057qib7 11757 1 These these DT cord-005453-4057qib7 11757 2 patients patient NNS cord-005453-4057qib7 11757 3 presented present VBD cord-005453-4057qib7 11757 4 different different JJ cord-005453-4057qib7 11757 5 hematological hematological JJ cord-005453-4057qib7 11757 6 neoplasms neoplasm NNS cord-005453-4057qib7 11757 7 . . . cord-005453-4057qib7 11758 1 Interestingly interestingly RB cord-005453-4057qib7 11758 2 , , , cord-005453-4057qib7 11758 3 4 4 CD cord-005453-4057qib7 11758 4 patients patient NNS cord-005453-4057qib7 11758 5 presented present VBN cord-005453-4057qib7 11758 6 lymphoid lymphoid JJ cord-005453-4057qib7 11758 7 neoplasm neoplasm NN cord-005453-4057qib7 11758 8 ( ( -LRB- cord-005453-4057qib7 11758 9 1 1 CD cord-005453-4057qib7 11758 10 acute acute JJ cord-005453-4057qib7 11758 11 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 11758 12 leukemia leukemia NN cord-005453-4057qib7 11758 13 ( ( -LRB- cord-005453-4057qib7 11758 14 ALL ALL NNP cord-005453-4057qib7 11758 15 - - HYPH cord-005453-4057qib7 11758 16 T T NNP cord-005453-4057qib7 11758 17 ) ) -RRB- cord-005453-4057qib7 11758 18 , , , cord-005453-4057qib7 11758 19 1 1 CD cord-005453-4057qib7 11758 20 dentritic dentritic JJ cord-005453-4057qib7 11758 21 cell cell NN cord-005453-4057qib7 11758 22 leukemia leukemia NN cord-005453-4057qib7 11758 23 ( ( -LRB- cord-005453-4057qib7 11758 24 DCL DCL NNP cord-005453-4057qib7 11758 25 ) ) -RRB- cord-005453-4057qib7 11758 26 and and CC cord-005453-4057qib7 11758 27 2 2 CD cord-005453-4057qib7 11758 28 hodking´s hodking´s CD cord-005453-4057qib7 11758 29 lymphoma lymphoma NN cord-005453-4057qib7 11758 30 ( ( -LRB- cord-005453-4057qib7 11758 31 HL HL NNP cord-005453-4057qib7 11758 32 ) ) -RRB- cord-005453-4057qib7 11758 33 ) ) -RRB- cord-005453-4057qib7 11758 34 . . . cord-005453-4057qib7 11759 1 HLA HLA NNP cord-005453-4057qib7 11759 2 loss loss NN cord-005453-4057qib7 11759 3 relapses relapse NNS cord-005453-4057qib7 11759 4 occurred occur VBD cord-005453-4057qib7 11759 5 later later RB cord-005453-4057qib7 11759 6 than than IN cord-005453-4057qib7 11759 7 classical classical JJ cord-005453-4057qib7 11759 8 relapses relapse NNS cord-005453-4057qib7 11759 9 ( ( -LRB- cord-005453-4057qib7 11759 10 370 370 CD cord-005453-4057qib7 11759 11 vs.166 vs.166 NNP cord-005453-4057qib7 11759 12 days day NNS cord-005453-4057qib7 11759 13 ) ) -RRB- cord-005453-4057qib7 11759 14 . . . cord-005453-4057qib7 11760 1 Regarding regard VBG cord-005453-4057qib7 11760 2 the the DT cord-005453-4057qib7 11760 3 treatment treatment NN cord-005453-4057qib7 11760 4 received receive VBN cord-005453-4057qib7 11760 5 ( ( -LRB- cord-005453-4057qib7 11760 6 Table table NN cord-005453-4057qib7 11760 7 1 1 CD cord-005453-4057qib7 11760 8 ) ) -RRB- cord-005453-4057qib7 11760 9 , , , cord-005453-4057qib7 11760 10 four four CD cord-005453-4057qib7 11760 11 patients patient NNS cord-005453-4057qib7 11760 12 were be VBD cord-005453-4057qib7 11760 13 studied study VBN cord-005453-4057qib7 11760 14 retrospectively retrospectively RB cord-005453-4057qib7 11760 15 . . . cord-005453-4057qib7 11761 1 Three three CD cord-005453-4057qib7 11761 2 of of IN cord-005453-4057qib7 11761 3 them -PRON- PRP cord-005453-4057qib7 11761 4 were be VBD cord-005453-4057qib7 11761 5 treated treat VBN cord-005453-4057qib7 11761 6 with with IN cord-005453-4057qib7 11761 7 donor donor NN cord-005453-4057qib7 11761 8 lymphocyte lymphocyte NN cord-005453-4057qib7 11761 9 infusions infusion NNS cord-005453-4057qib7 11761 10 ( ( -LRB- cord-005453-4057qib7 11761 11 DLIs DLIs NNP cord-005453-4057qib7 11761 12 ) ) -RRB- cord-005453-4057qib7 11761 13 + + CC cord-005453-4057qib7 11761 14 chemotherapy chemotherapy NN cord-005453-4057qib7 11761 15 or or CC cord-005453-4057qib7 11761 16 other other JJ cord-005453-4057qib7 11761 17 drugs drug NNS cord-005453-4057qib7 11761 18 at at IN cord-005453-4057qib7 11761 19 the the DT cord-005453-4057qib7 11761 20 time time NN cord-005453-4057qib7 11761 21 of of IN cord-005453-4057qib7 11761 22 the the DT cord-005453-4057qib7 11761 23 relapse relapse NN cord-005453-4057qib7 11761 24 . . . cord-005453-4057qib7 11762 1 The the DT cord-005453-4057qib7 11762 2 other other JJ cord-005453-4057qib7 11762 3 patient patient NN cord-005453-4057qib7 11762 4 did do VBD cord-005453-4057qib7 11762 5 not not RB cord-005453-4057qib7 11762 6 receive receive VB cord-005453-4057qib7 11762 7 any any DT cord-005453-4057qib7 11762 8 treatment treatment NN cord-005453-4057qib7 11762 9 . . . cord-005453-4057qib7 11763 1 In in IN cord-005453-4057qib7 11763 2 the the DT cord-005453-4057qib7 11763 3 end end NN cord-005453-4057qib7 11763 4 , , , cord-005453-4057qib7 11763 5 all all DT cord-005453-4057qib7 11763 6 4 4 CD cord-005453-4057qib7 11763 7 patients patient NNS cord-005453-4057qib7 11763 8 died die VBD cord-005453-4057qib7 11763 9 from from IN cord-005453-4057qib7 11763 10 disease disease NN cord-005453-4057qib7 11763 11 progression progression NN cord-005453-4057qib7 11763 12 . . . cord-005453-4057qib7 11764 1 Prospectively prospectively RB cord-005453-4057qib7 11764 2 , , , cord-005453-4057qib7 11764 3 we -PRON- PRP cord-005453-4057qib7 11764 4 detected detect VBD cord-005453-4057qib7 11764 5 HLA HLA NNP cord-005453-4057qib7 11764 6 loss loss NN cord-005453-4057qib7 11764 7 at at IN cord-005453-4057qib7 11764 8 relapse relapse NN cord-005453-4057qib7 11764 9 in in IN cord-005453-4057qib7 11764 10 other other JJ cord-005453-4057qib7 11764 11 two two CD cord-005453-4057qib7 11764 12 patients patient NNS cord-005453-4057qib7 11764 13 . . . cord-005453-4057qib7 11765 1 At at IN cord-005453-4057qib7 11765 2 the the DT cord-005453-4057qib7 11765 3 moment moment NN cord-005453-4057qib7 11765 4 of of IN cord-005453-4057qib7 11765 5 relapse relapse NN cord-005453-4057qib7 11765 6 , , , cord-005453-4057qib7 11765 7 the the DT cord-005453-4057qib7 11765 8 first first JJ cord-005453-4057qib7 11765 9 case case NN cord-005453-4057qib7 11765 10 received receive VBD cord-005453-4057qib7 11765 11 brentuximab brentuximab NNS cord-005453-4057qib7 11765 12 + + CC cord-005453-4057qib7 11765 13 Haplo Haplo NNP cord-005453-4057qib7 11765 14 - - HYPH cord-005453-4057qib7 11765 15 HSCT HSCT NNP cord-005453-4057qib7 11765 16 from from IN cord-005453-4057qib7 11765 17 alternative alternative JJ cord-005453-4057qib7 11765 18 donor donor NN cord-005453-4057qib7 11765 19 and and CC cord-005453-4057qib7 11765 20 the the DT cord-005453-4057qib7 11765 21 other other JJ cord-005453-4057qib7 11765 22 case case NN cord-005453-4057qib7 11765 23 received receive VBD cord-005453-4057qib7 11765 24 daratumumab daratumumab NNP cord-005453-4057qib7 11765 25 + + CC cord-005453-4057qib7 11765 26 Haplo Haplo NNP cord-005453-4057qib7 11765 27 - - HYPH cord-005453-4057qib7 11765 28 HSCT HSCT NNP cord-005453-4057qib7 11765 29 ( ( -LRB- cord-005453-4057qib7 11765 30 pending pende VBG cord-005453-4057qib7 11765 31 ) ) -RRB- cord-005453-4057qib7 11765 32 . . . cord-005453-4057qib7 11766 1 Both both DT cord-005453-4057qib7 11766 2 patients patient NNS cord-005453-4057qib7 11766 3 are be VBP cord-005453-4057qib7 11766 4 alive alive JJ cord-005453-4057qib7 11766 5 , , , cord-005453-4057qib7 11766 6 the the DT cord-005453-4057qib7 11766 7 first first JJ cord-005453-4057qib7 11766 8 one one CD cord-005453-4057qib7 11766 9 in in IN cord-005453-4057qib7 11766 10 complete complete JJ cord-005453-4057qib7 11766 11 remission remission NN cord-005453-4057qib7 11766 12 ( ( -LRB- cord-005453-4057qib7 11766 13 CR CR NNP cord-005453-4057qib7 11766 14 ) ) -RRB- cord-005453-4057qib7 11766 15 and and CC cord-005453-4057qib7 11766 16 the the DT cord-005453-4057qib7 11766 17 second second JJ cord-005453-4057qib7 11766 18 one one CD cord-005453-4057qib7 11766 19 in in IN cord-005453-4057qib7 11766 20 partial partial JJ cord-005453-4057qib7 11766 21 remission remission NN cord-005453-4057qib7 11766 22 ( ( -LRB- cord-005453-4057qib7 11766 23 PR PR NNP cord-005453-4057qib7 11766 24 ) ) -RRB- cord-005453-4057qib7 11766 25 . . . cord-005453-4057qib7 11767 1 Conclusions conclusion NNS cord-005453-4057qib7 11767 2 : : : cord-005453-4057qib7 11768 1 The the DT cord-005453-4057qib7 11768 2 frequency frequency NN cord-005453-4057qib7 11768 3 of of IN cord-005453-4057qib7 11768 4 HLA HLA NNP cord-005453-4057qib7 11768 5 loss loss NN cord-005453-4057qib7 11768 6 at at IN cord-005453-4057qib7 11768 7 relapse relapse NN cord-005453-4057qib7 11768 8 is be VBZ cord-005453-4057qib7 11768 9 similar similar JJ cord-005453-4057qib7 11768 10 in in IN cord-005453-4057qib7 11768 11 our -PRON- PRP$ cord-005453-4057qib7 11768 12 cohort cohort NN cord-005453-4057qib7 11768 13 to to IN cord-005453-4057qib7 11768 14 what what WP cord-005453-4057qib7 11768 15 is be VBZ cord-005453-4057qib7 11768 16 described describe VBN cord-005453-4057qib7 11768 17 in in IN cord-005453-4057qib7 11768 18 the the DT cord-005453-4057qib7 11768 19 literature literature NN cord-005453-4057qib7 11768 20 . . . cord-005453-4057qib7 11769 1 HLA HLA NNP cord-005453-4057qib7 11769 2 loss loss NN cord-005453-4057qib7 11769 3 has have VBZ cord-005453-4057qib7 11769 4 been be VBN cord-005453-4057qib7 11769 5 identified identify VBN cord-005453-4057qib7 11769 6 in in IN cord-005453-4057qib7 11769 7 patients patient NNS cord-005453-4057qib7 11769 8 with with IN cord-005453-4057qib7 11769 9 lymphoid lymphoid JJ cord-005453-4057qib7 11769 10 neoplasms neoplasm NNS cord-005453-4057qib7 11769 11 , , , cord-005453-4057qib7 11769 12 while while IN cord-005453-4057qib7 11769 13 this this DT cord-005453-4057qib7 11769 14 mechanism mechanism NN cord-005453-4057qib7 11769 15 has have VBZ cord-005453-4057qib7 11769 16 not not RB cord-005453-4057qib7 11769 17 been be VBN cord-005453-4057qib7 11769 18 previously previously RB cord-005453-4057qib7 11769 19 described describe VBN cord-005453-4057qib7 11769 20 in in IN cord-005453-4057qib7 11769 21 such such JJ cord-005453-4057qib7 11769 22 diseases disease NNS cord-005453-4057qib7 11769 23 . . . cord-005453-4057qib7 11770 1 The the DT cord-005453-4057qib7 11770 2 analysis analysis NN cord-005453-4057qib7 11770 3 of of IN cord-005453-4057qib7 11770 4 this this DT cord-005453-4057qib7 11770 5 immune immune JJ cord-005453-4057qib7 11770 6 evasion evasion NN cord-005453-4057qib7 11770 7 mechanism mechanism NN cord-005453-4057qib7 11770 8 should should MD cord-005453-4057qib7 11770 9 be be VB cord-005453-4057qib7 11770 10 implemented implement VBN cord-005453-4057qib7 11770 11 in in IN cord-005453-4057qib7 11770 12 the the DT cord-005453-4057qib7 11770 13 routine routine JJ cord-005453-4057qib7 11770 14 screening screening NN cord-005453-4057qib7 11770 15 of of IN cord-005453-4057qib7 11770 16 patients patient NNS cord-005453-4057qib7 11770 17 transplanted transplant VBN cord-005453-4057qib7 11770 18 from from IN cord-005453-4057qib7 11770 19 haploidentical haploidentical JJ cord-005453-4057qib7 11770 20 donors donor NNS cord-005453-4057qib7 11770 21 in in IN cord-005453-4057qib7 11770 22 order order NN cord-005453-4057qib7 11770 23 to to TO cord-005453-4057qib7 11770 24 design design VB cord-005453-4057qib7 11770 25 effective effective JJ cord-005453-4057qib7 11770 26 rescue rescue NN cord-005453-4057qib7 11770 27 strategies strategy NNS cord-005453-4057qib7 11770 28 . . . cord-005453-4057qib7 11771 1 These these DT cord-005453-4057qib7 11771 2 treatments treatment NNS cord-005453-4057qib7 11771 3 should should MD cord-005453-4057qib7 11771 4 not not RB cord-005453-4057qib7 11771 5 be be VB cord-005453-4057qib7 11771 6 based base VBN cord-005453-4057qib7 11771 7 on on IN cord-005453-4057qib7 11771 8 DLIs dli NNS cord-005453-4057qib7 11771 9 or or CC cord-005453-4057qib7 11771 10 second second JJ cord-005453-4057qib7 11771 11 transplantation transplantation NN cord-005453-4057qib7 11771 12 with with IN cord-005453-4057qib7 11771 13 the the DT cord-005453-4057qib7 11771 14 same same JJ cord-005453-4057qib7 11771 15 donor donor NN cord-005453-4057qib7 11771 16 , , , cord-005453-4057qib7 11771 17 instead instead RB cord-005453-4057qib7 11771 18 , , , cord-005453-4057qib7 11771 19 alternative alternative JJ cord-005453-4057qib7 11771 20 donors donor NNS cord-005453-4057qib7 11771 21 should should MD cord-005453-4057qib7 11771 22 be be VB cord-005453-4057qib7 11771 23 used use VBN cord-005453-4057qib7 11771 24 . . . cord-005453-4057qib7 11772 1 Background background NN cord-005453-4057qib7 11772 2 : : : cord-005453-4057qib7 11773 1 An an DT cord-005453-4057qib7 11773 2 adequate adequate JJ cord-005453-4057qib7 11773 3 immune immune JJ cord-005453-4057qib7 11773 4 reconstitution reconstitution NN cord-005453-4057qib7 11773 5 ( ( -LRB- cord-005453-4057qib7 11773 6 IR IR NNP cord-005453-4057qib7 11773 7 ) ) -RRB- cord-005453-4057qib7 11773 8 is be VBZ cord-005453-4057qib7 11773 9 crucial crucial JJ cord-005453-4057qib7 11773 10 to to TO cord-005453-4057qib7 11773 11 reduce reduce VB cord-005453-4057qib7 11773 12 transplant transplant NN cord-005453-4057qib7 11773 13 toxicity toxicity NN cord-005453-4057qib7 11773 14 , , , cord-005453-4057qib7 11773 15 relapse relapse NN cord-005453-4057qib7 11773 16 rate rate NN cord-005453-4057qib7 11773 17 and and CC cord-005453-4057qib7 11773 18 mortality mortality NN cord-005453-4057qib7 11773 19 after after IN cord-005453-4057qib7 11773 20 allogeneic allogeneic NN cord-005453-4057qib7 11773 21 stem stem NN cord-005453-4057qib7 11773 22 cell cell NN cord-005453-4057qib7 11773 23 transplantation transplantation NN cord-005453-4057qib7 11773 24 ( ( -LRB- cord-005453-4057qib7 11773 25 alloHSCT alloHSCT NNP cord-005453-4057qib7 11773 26 ) ) -RRB- cord-005453-4057qib7 11773 27 . . . cord-005453-4057qib7 11774 1 The the DT cord-005453-4057qib7 11774 2 aim aim NN cord-005453-4057qib7 11774 3 of of IN cord-005453-4057qib7 11774 4 this this DT cord-005453-4057qib7 11774 5 , , , cord-005453-4057qib7 11774 6 single single JJ cord-005453-4057qib7 11774 7 center center NN cord-005453-4057qib7 11774 8 retrospective retrospective JJ cord-005453-4057qib7 11774 9 study study NN cord-005453-4057qib7 11774 10 was be VBD cord-005453-4057qib7 11774 11 to to TO cord-005453-4057qib7 11774 12 investigate investigate VB cord-005453-4057qib7 11774 13 the the DT cord-005453-4057qib7 11774 14 correlation correlation NN cord-005453-4057qib7 11774 15 between between IN cord-005453-4057qib7 11774 16 the the DT cord-005453-4057qib7 11774 17 recovery recovery NN cord-005453-4057qib7 11774 18 of of IN cord-005453-4057qib7 11774 19 different different JJ cord-005453-4057qib7 11774 20 lymphocyte lymphocyte NN cord-005453-4057qib7 11774 21 subpopulations subpopulation NNS cord-005453-4057qib7 11774 22 with with IN cord-005453-4057qib7 11774 23 the the DT cord-005453-4057qib7 11774 24 main main JJ cord-005453-4057qib7 11774 25 transplant transplant NN cord-005453-4057qib7 11774 26 outcomes outcome NNS cord-005453-4057qib7 11774 27 , , , cord-005453-4057qib7 11774 28 including include VBG cord-005453-4057qib7 11774 29 overall overall JJ cord-005453-4057qib7 11774 30 survival survival NN cord-005453-4057qib7 11774 31 ( ( -LRB- cord-005453-4057qib7 11774 32 OS OS NNP cord-005453-4057qib7 11774 33 ) ) -RRB- cord-005453-4057qib7 11774 34 , , , cord-005453-4057qib7 11774 35 disease disease NNP cord-005453-4057qib7 11774 36 free free JJ cord-005453-4057qib7 11774 37 survival survival NN cord-005453-4057qib7 11774 38 ( ( -LRB- cord-005453-4057qib7 11774 39 DFS DFS NNP cord-005453-4057qib7 11774 40 ) ) -RRB- cord-005453-4057qib7 11774 41 and and CC cord-005453-4057qib7 11774 42 non non JJ cord-005453-4057qib7 11774 43 - - JJ cord-005453-4057qib7 11774 44 relapse relapse JJ cord-005453-4057qib7 11774 45 mortality mortality NN cord-005453-4057qib7 11774 46 ( ( -LRB- cord-005453-4057qib7 11774 47 NRM NRM NNP cord-005453-4057qib7 11774 48 ) ) -RRB- cord-005453-4057qib7 11774 49 . . . cord-005453-4057qib7 11775 1 Methods method NNS cord-005453-4057qib7 11775 2 : : : cord-005453-4057qib7 11775 3 We -PRON- PRP cord-005453-4057qib7 11775 4 analyzed analyze VBD cord-005453-4057qib7 11775 5 the the DT cord-005453-4057qib7 11775 6 IR IR NNP cord-005453-4057qib7 11775 7 of of IN cord-005453-4057qib7 11775 8 177 177 CD cord-005453-4057qib7 11775 9 adult adult NN cord-005453-4057qib7 11775 10 patients patient NNS cord-005453-4057qib7 11775 11 ( ( -LRB- cord-005453-4057qib7 11775 12 AML AML NNP cord-005453-4057qib7 11775 13 n=62 n=62 NN cord-005453-4057qib7 11775 14 , , , cord-005453-4057qib7 11775 15 ALL all DT cord-005453-4057qib7 11775 16 n=41 n=41 NN cord-005453-4057qib7 11775 17 , , , cord-005453-4057qib7 11775 18 MDS MDS NNP cord-005453-4057qib7 11775 19 n= n= NNP cord-005453-4057qib7 11775 20 24 24 CD cord-005453-4057qib7 11775 21 , , , cord-005453-4057qib7 11775 22 NHL NHL NNP cord-005453-4057qib7 11775 23 n=9 n=9 NN cord-005453-4057qib7 11775 24 , , , cord-005453-4057qib7 11775 25 HD HD NNP cord-005453-4057qib7 11775 26 n=2 n=2 NNS cord-005453-4057qib7 11775 27 , , , cord-005453-4057qib7 11775 28 CLL CLL NNP cord-005453-4057qib7 11775 29 n=4 n=4 NNS cord-005453-4057qib7 11775 30 , , , cord-005453-4057qib7 11775 31 CML CML NNP cord-005453-4057qib7 11775 32 n=7 n=7 NNS cord-005453-4057qib7 11775 33 , , , cord-005453-4057qib7 11775 34 MM MM NNP cord-005453-4057qib7 11775 35 , , , cord-005453-4057qib7 11775 36 n=11 n=11 NNP cord-005453-4057qib7 11775 37 , , , cord-005453-4057qib7 11775 38 MPN MPN NNP cord-005453-4057qib7 11775 39 n=10 n=10 NNP cord-005453-4057qib7 11775 40 ) ) -RRB- cord-005453-4057qib7 11775 41 who who WP cord-005453-4057qib7 11775 42 underwent undergo VBD cord-005453-4057qib7 11775 43 ( ( -LRB- cord-005453-4057qib7 11775 44 alloHSCT alloHSCT NNP cord-005453-4057qib7 11775 45 ) ) -RRB- cord-005453-4057qib7 11775 46 between between IN cord-005453-4057qib7 11775 47 January January NNP cord-005453-4057qib7 11775 48 2013 2013 CD cord-005453-4057qib7 11775 49 and and CC cord-005453-4057qib7 11775 50 March March NNP cord-005453-4057qib7 11775 51 2017 2017 CD cord-005453-4057qib7 11775 52 . . . cord-005453-4057qib7 11776 1 Median median JJ cord-005453-4057qib7 11776 2 age age NN cord-005453-4057qib7 11776 3 at at IN cord-005453-4057qib7 11776 4 transplant transplant NN cord-005453-4057qib7 11776 5 was be VBD cord-005453-4057qib7 11776 6 52 52 CD cord-005453-4057qib7 11776 7 years year NNS cord-005453-4057qib7 11777 1 ( ( -LRB- cord-005453-4057qib7 11777 2 range range NNP cord-005453-4057qib7 11777 3 17 17 CD cord-005453-4057qib7 11777 4 . . . cord-005453-4057qib7 11778 1 3 3 LS cord-005453-4057qib7 11778 2 - - SYM cord-005453-4057qib7 11778 3 71.3 71.3 CD cord-005453-4057qib7 11778 4 ) ) -RRB- cord-005453-4057qib7 11778 5 with with IN cord-005453-4057qib7 11778 6 male male JJ cord-005453-4057qib7 11778 7 / / SYM cord-005453-4057qib7 11778 8 female female JJ cord-005453-4057qib7 11778 9 ratio ratio NN cord-005453-4057qib7 11778 10 of of IN cord-005453-4057qib7 11778 11 62 62 CD cord-005453-4057qib7 11778 12 % % NN cord-005453-4057qib7 11778 13 . . . cord-005453-4057qib7 11779 1 Donors donor NNS cord-005453-4057qib7 11779 2 were be VBD cord-005453-4057qib7 11779 3 HLAidentical hlaidentical JJ cord-005453-4057qib7 11779 4 siblings sibling NNS cord-005453-4057qib7 11779 5 ( ( -LRB- cord-005453-4057qib7 11779 6 n=39 n=39 NNP cord-005453-4057qib7 11779 7 , , , cord-005453-4057qib7 11779 8 22 22 CD cord-005453-4057qib7 11779 9 % % NN cord-005453-4057qib7 11779 10 ) ) -RRB- cord-005453-4057qib7 11779 11 , , , cord-005453-4057qib7 11779 12 family family NN cord-005453-4057qib7 11779 13 haploidentical haploidentical JJ cord-005453-4057qib7 11779 14 ( ( -LRB- cord-005453-4057qib7 11779 15 n=11 n=11 NNP cord-005453-4057qib7 11779 16 , , , cord-005453-4057qib7 11779 17 6 6 CD cord-005453-4057qib7 11779 18 % % NN cord-005453-4057qib7 11779 19 ) ) -RRB- cord-005453-4057qib7 11779 20 , , , cord-005453-4057qib7 11779 21 matched match VBN cord-005453-4057qib7 11779 22 unrelated unrelated JJ cord-005453-4057qib7 11779 23 ( ( -LRB- cord-005453-4057qib7 11779 24 109 109 CD cord-005453-4057qib7 11779 25 , , , cord-005453-4057qib7 11779 26 62 62 CD cord-005453-4057qib7 11779 27 % % NN cord-005453-4057qib7 11779 28 ) ) -RRB- cord-005453-4057qib7 11779 29 , , , cord-005453-4057qib7 11779 30 mismatched mismatch VBN cord-005453-4057qib7 11779 31 unrelated unrelated JJ cord-005453-4057qib7 11779 32 ( ( -LRB- cord-005453-4057qib7 11779 33 n=11 n=11 FW cord-005453-4057qib7 11779 34 , , , cord-005453-4057qib7 11779 35 6 6 CD cord-005453-4057qib7 11779 36 % % NN cord-005453-4057qib7 11779 37 ) ) -RRB- cord-005453-4057qib7 11779 38 and and CC cord-005453-4057qib7 11779 39 cord cord NN cord-005453-4057qib7 11779 40 blood blood NN cord-005453-4057qib7 11779 41 units unit NNS cord-005453-4057qib7 11779 42 ( ( -LRB- cord-005453-4057qib7 11779 43 n=7 n=7 NNS cord-005453-4057qib7 11779 44 , , , cord-005453-4057qib7 11779 45 4 4 CD cord-005453-4057qib7 11779 46 % % NN cord-005453-4057qib7 11779 47 ) ) -RRB- cord-005453-4057qib7 11779 48 . . . cord-005453-4057qib7 11780 1 The the DT cord-005453-4057qib7 11780 2 stem stem NN cord-005453-4057qib7 11780 3 cell cell NN cord-005453-4057qib7 11780 4 source source NN cord-005453-4057qib7 11780 5 was be VBD cord-005453-4057qib7 11780 6 the the DT cord-005453-4057qib7 11780 7 bone bone NN cord-005453-4057qib7 11780 8 marrow marrow NN cord-005453-4057qib7 11780 9 ( ( -LRB- cord-005453-4057qib7 11780 10 BM BM NNP cord-005453-4057qib7 11780 11 ) ) -RRB- cord-005453-4057qib7 11780 12 in in IN cord-005453-4057qib7 11780 13 30 30 CD cord-005453-4057qib7 11780 14 patients patient NNS cord-005453-4057qib7 11780 15 ( ( -LRB- cord-005453-4057qib7 11780 16 17 17 CD cord-005453-4057qib7 11780 17 % % NN cord-005453-4057qib7 11780 18 ) ) -RRB- cord-005453-4057qib7 11780 19 , , , cord-005453-4057qib7 11780 20 the the DT cord-005453-4057qib7 11780 21 cord cord NN cord-005453-4057qib7 11780 22 blood blood NN cord-005453-4057qib7 11780 23 in in IN cord-005453-4057qib7 11780 24 7 7 CD cord-005453-4057qib7 11780 25 ( ( -LRB- cord-005453-4057qib7 11780 26 4 4 CD cord-005453-4057qib7 11780 27 % % NN cord-005453-4057qib7 11780 28 ) ) -RRB- cord-005453-4057qib7 11780 29 and and CC cord-005453-4057qib7 11780 30 G G NNP cord-005453-4057qib7 11780 31 - - HYPH cord-005453-4057qib7 11780 32 CSF CSF NNP cord-005453-4057qib7 11780 33 mobilized mobilize VBD cord-005453-4057qib7 11780 34 peripheral peripheral JJ cord-005453-4057qib7 11780 35 blood blood NN cord-005453-4057qib7 11780 36 in in IN cord-005453-4057qib7 11780 37 140 140 CD cord-005453-4057qib7 11780 38 ( ( -LRB- cord-005453-4057qib7 11780 39 79 79 CD cord-005453-4057qib7 11780 40 % % NN cord-005453-4057qib7 11780 41 ) ) -RRB- cord-005453-4057qib7 11780 42 . . . cord-005453-4057qib7 11781 1 The the DT cord-005453-4057qib7 11781 2 conditioning conditioning NN cord-005453-4057qib7 11781 3 regimen regimen NN cord-005453-4057qib7 11781 4 was be VBD cord-005453-4057qib7 11781 5 myeloablative myeloablative JJ cord-005453-4057qib7 11781 6 in in IN cord-005453-4057qib7 11781 7 99(56 99(56 CD cord-005453-4057qib7 11781 8 % % NN cord-005453-4057qib7 11781 9 ) ) -RRB- cord-005453-4057qib7 11781 10 transplant transplant NN cord-005453-4057qib7 11781 11 , , , cord-005453-4057qib7 11781 12 reduced reduced JJ cord-005453-4057qib7 11781 13 intensity intensity NN cord-005453-4057qib7 11781 14 in in IN cord-005453-4057qib7 11781 15 75 75 CD cord-005453-4057qib7 11781 16 ( ( -LRB- cord-005453-4057qib7 11781 17 42 42 CD cord-005453-4057qib7 11781 18 % % NN cord-005453-4057qib7 11781 19 ) ) -RRB- cord-005453-4057qib7 11781 20 and and CC cord-005453-4057qib7 11781 21 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 11781 22 in in IN cord-005453-4057qib7 11781 23 3 3 CD cord-005453-4057qib7 11781 24 ( ( -LRB- cord-005453-4057qib7 11781 25 2 2 CD cord-005453-4057qib7 11781 26 % % NN cord-005453-4057qib7 11781 27 ) ) -RRB- cord-005453-4057qib7 11781 28 . . . cord-005453-4057qib7 11782 1 GVHD GVHD NNP cord-005453-4057qib7 11782 2 prophylaxis prophylaxis NN cord-005453-4057qib7 11782 3 was be VBD cord-005453-4057qib7 11782 4 based base VBN cord-005453-4057qib7 11782 5 on on IN cord-005453-4057qib7 11782 6 calcineurin calcineurin NNP cord-005453-4057qib7 11782 7 inhibitors inhibitor NNS cord-005453-4057qib7 11782 8 in in IN cord-005453-4057qib7 11782 9 combination combination NN cord-005453-4057qib7 11782 10 with with IN cord-005453-4057qib7 11782 11 Methotrexate Methotrexate NNP cord-005453-4057qib7 11782 12 or or CC cord-005453-4057qib7 11782 13 Mofetil Mofetil NNP cord-005453-4057qib7 11782 14 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 11782 15 . . . cord-005453-4057qib7 11783 1 Antilymphocytes Antilymphocytes NNPS cord-005453-4057qib7 11783 2 Immunoglobulins Immunoglobulins NNP cord-005453-4057qib7 11783 3 was be VBD cord-005453-4057qib7 11783 4 used use VBN cord-005453-4057qib7 11783 5 in in IN cord-005453-4057qib7 11783 6 145 145 CD cord-005453-4057qib7 11783 7 patients patient NNS cord-005453-4057qib7 11783 8 ( ( -LRB- cord-005453-4057qib7 11783 9 81 81 CD cord-005453-4057qib7 11783 10 % % NN cord-005453-4057qib7 11783 11 ) ) -RRB- cord-005453-4057qib7 11783 12 ( ( -LRB- cord-005453-4057qib7 11783 13 Anti Anti NNP cord-005453-4057qib7 11783 14 Thymocytes Thymocytes NNP cord-005453-4057qib7 11783 15 Globulin Globulin NNP cord-005453-4057qib7 11783 16 , , , cord-005453-4057qib7 11783 17 ATG ATG NNP cord-005453-4057qib7 11783 18 Sanofi Sanofi NNP cord-005453-4057qib7 11783 19 - - HYPH cord-005453-4057qib7 11783 20 Genzyme Genzyme NNP cord-005453-4057qib7 11783 21 in in IN cord-005453-4057qib7 11783 22 114 114 CD cord-005453-4057qib7 11783 23 or or CC cord-005453-4057qib7 11783 24 Anti Anti NNP cord-005453-4057qib7 11783 25 T T NNP cord-005453-4057qib7 11783 26 - - HYPH cord-005453-4057qib7 11783 27 lymphocyte lymphocyte NN cord-005453-4057qib7 11783 28 globulin globulin NN cord-005453-4057qib7 11783 29 , , , cord-005453-4057qib7 11783 30 ATLG ATLG NNP cord-005453-4057qib7 11783 31 -Neovii -neovii VBP cord-005453-4057qib7 11783 32 Biotech Biotech NNP cord-005453-4057qib7 11783 33 , , , cord-005453-4057qib7 11783 34 in in IN cord-005453-4057qib7 11783 35 31 31 CD cord-005453-4057qib7 11783 36 ) ) -RRB- cord-005453-4057qib7 11783 37 . . . cord-005453-4057qib7 11784 1 The the DT cord-005453-4057qib7 11784 2 peripheral peripheral JJ cord-005453-4057qib7 11784 3 blood blood NN cord-005453-4057qib7 11784 4 lymphocyte lymphocyte NN cord-005453-4057qib7 11784 5 subsets subset NNS cord-005453-4057qib7 11784 6 ( ( -LRB- cord-005453-4057qib7 11784 7 CD3 CD3 NNP cord-005453-4057qib7 11784 8 + + CC cord-005453-4057qib7 11784 9 , , , cord-005453-4057qib7 11784 10 CD3+CD4 cd3+cd4 CD cord-005453-4057qib7 11784 11 + + CC cord-005453-4057qib7 11784 12 , , , cord-005453-4057qib7 11784 13 CD3+CD8 CD3+CD8 NNP cord-005453-4057qib7 11784 14 + + SYM cord-005453-4057qib7 11784 15 , , , cord-005453-4057qib7 11784 16 CD19 CD19 NNP cord-005453-4057qib7 11784 17 + + CC cord-005453-4057qib7 11784 18 ( ( -LRB- cord-005453-4057qib7 11784 19 B b NN cord-005453-4057qib7 11784 20 cells cell NNS cord-005453-4057qib7 11784 21 ) ) -RRB- cord-005453-4057qib7 11784 22 and and CC cord-005453-4057qib7 11784 23 CD16+CD56 CD16+CD56 NNP cord-005453-4057qib7 11784 24 + + CC cord-005453-4057qib7 11785 1 ( ( -LRB- cord-005453-4057qib7 11785 2 NK NK NNP cord-005453-4057qib7 11785 3 ) ) -RRB- cord-005453-4057qib7 11785 4 were be VBD cord-005453-4057qib7 11785 5 analyzed analyze VBN cord-005453-4057qib7 11785 6 by by IN cord-005453-4057qib7 11785 7 flow flow NN cord-005453-4057qib7 11785 8 cytometry cytometry NN cord-005453-4057qib7 11785 9 at at IN cord-005453-4057qib7 11785 10 1 1 CD cord-005453-4057qib7 11785 11 , , , cord-005453-4057qib7 11785 12 2 2 CD cord-005453-4057qib7 11785 13 , , , cord-005453-4057qib7 11785 14 3 3 CD cord-005453-4057qib7 11785 15 , , , cord-005453-4057qib7 11785 16 6 6 CD cord-005453-4057qib7 11785 17 , , , cord-005453-4057qib7 11785 18 12 12 CD cord-005453-4057qib7 11785 19 and and CC cord-005453-4057qib7 11785 20 24 24 CD cord-005453-4057qib7 11785 21 months month NNS cord-005453-4057qib7 11785 22 after after IN cord-005453-4057qib7 11785 23 HSCT HSCT NNP cord-005453-4057qib7 11785 24 . . . cord-005453-4057qib7 11786 1 Post post JJ cord-005453-4057qib7 11786 2 - - JJ cord-005453-4057qib7 11786 3 transplant transplant NN cord-005453-4057qib7 11786 4 engraftment engraftment NN cord-005453-4057qib7 11786 5 was be VBD cord-005453-4057qib7 11786 6 molecularly molecularly RB cord-005453-4057qib7 11786 7 determined determine VBN cord-005453-4057qib7 11786 8 by by IN cord-005453-4057qib7 11786 9 VNTR VNTR NNP cord-005453-4057qib7 11786 10 analysis analysis NN cord-005453-4057qib7 11786 11 . . . cord-005453-4057qib7 11787 1 Results result NNS cord-005453-4057qib7 11787 2 : : : cord-005453-4057qib7 11788 1 As as IN cord-005453-4057qib7 11788 2 detailed detailed JJ cord-005453-4057qib7 11788 3 in in IN cord-005453-4057qib7 11788 4 Table table NN cord-005453-4057qib7 11788 5 1 1 CD cord-005453-4057qib7 11788 6 the the DT cord-005453-4057qib7 11788 7 proportion proportion NN cord-005453-4057qib7 11788 8 of of IN cord-005453-4057qib7 11788 9 full full JJ cord-005453-4057qib7 11788 10 donor donor NN cord-005453-4057qib7 11788 11 chimerism chimerism NN cord-005453-4057qib7 11788 12 analyzed analyze VBN cord-005453-4057qib7 11788 13 in in IN cord-005453-4057qib7 11788 14 the the DT cord-005453-4057qib7 11788 15 peripheral peripheral JJ cord-005453-4057qib7 11788 16 blood blood NN cord-005453-4057qib7 11788 17 T t NN cord-005453-4057qib7 11788 18 lymphocytes lymphocyte NNS cord-005453-4057qib7 11788 19 improved improve VBN cord-005453-4057qib7 11788 20 progressively progressively RB cord-005453-4057qib7 11788 21 after after IN cord-005453-4057qib7 11788 22 transplantation transplantation NN cord-005453-4057qib7 11788 23 and and CC cord-005453-4057qib7 11788 24 the the DT cord-005453-4057qib7 11788 25 same same JJ cord-005453-4057qib7 11788 26 pattern pattern NN cord-005453-4057qib7 11788 27 was be VBD cord-005453-4057qib7 11788 28 observed observe VBN cord-005453-4057qib7 11788 29 when when WRB cord-005453-4057qib7 11788 30 the the DT cord-005453-4057qib7 11788 31 chimeric chimeric JJ cord-005453-4057qib7 11788 32 status status NN cord-005453-4057qib7 11788 33 was be VBD cord-005453-4057qib7 11788 34 measured measure VBN cord-005453-4057qib7 11788 35 in in IN cord-005453-4057qib7 11788 36 bone bone NN cord-005453-4057qib7 11788 37 marrow marrow NN cord-005453-4057qib7 11788 38 mononuclear mononuclear NN cord-005453-4057qib7 11788 39 cells cell NNS cord-005453-4057qib7 11788 40 . . . cord-005453-4057qib7 11789 1 To to TO cord-005453-4057qib7 11789 2 favor favor VB cord-005453-4057qib7 11789 3 the the DT cord-005453-4057qib7 11789 4 achievement achievement NN cord-005453-4057qib7 11789 5 of of IN cord-005453-4057qib7 11789 6 a a DT cord-005453-4057qib7 11789 7 full full JJ cord-005453-4057qib7 11789 8 donor donor NN cord-005453-4057qib7 11789 9 chimerism chimerism NN cord-005453-4057qib7 11789 10 , , , cord-005453-4057qib7 11789 11 DLI DLI NNP cord-005453-4057qib7 11789 12 were be VBD cord-005453-4057qib7 11789 13 performed perform VBN cord-005453-4057qib7 11789 14 in in IN cord-005453-4057qib7 11789 15 26 26 CD cord-005453-4057qib7 11789 16 patients patient NNS cord-005453-4057qib7 11789 17 starting start VBG cord-005453-4057qib7 11789 18 at at IN cord-005453-4057qib7 11789 19 the the DT cord-005453-4057qib7 11789 20 median median NN cord-005453-4057qib7 11789 21 of of IN cord-005453-4057qib7 11789 22 96 96 CD cord-005453-4057qib7 11789 23 days day NNS cord-005453-4057qib7 11789 24 after after IN cord-005453-4057qib7 11789 25 transplant transplant NN cord-005453-4057qib7 11789 26 ( ( -LRB- cord-005453-4057qib7 11789 27 range:34 range:34 NN cord-005453-4057qib7 11789 28 - - HYPH cord-005453-4057qib7 11789 29 447 447 CD cord-005453-4057qib7 11789 30 ) ) -RRB- cord-005453-4057qib7 11789 31 . . . cord-005453-4057qib7 11790 1 With with IN cord-005453-4057qib7 11790 2 a a DT cord-005453-4057qib7 11790 3 median median JJ cord-005453-4057qib7 11790 4 follow follow NN cord-005453-4057qib7 11790 5 - - HYPH cord-005453-4057qib7 11790 6 up up RP cord-005453-4057qib7 11790 7 observation observation NN cord-005453-4057qib7 11790 8 of of IN cord-005453-4057qib7 11790 9 25 25 CD cord-005453-4057qib7 11790 10 months month NNS cord-005453-4057qib7 11790 11 ( ( -LRB- cord-005453-4057qib7 11790 12 range range VBP cord-005453-4057qib7 11790 13 7 7 CD cord-005453-4057qib7 11790 14 - - SYM cord-005453-4057qib7 11790 15 61 61 CD cord-005453-4057qib7 11790 16 ) ) -RRB- cord-005453-4057qib7 11790 17 , , , cord-005453-4057qib7 11790 18 the the DT cord-005453-4057qib7 11790 19 one one CD cord-005453-4057qib7 11790 20 year year NN cord-005453-4057qib7 11790 21 OS OS NNP cord-005453-4057qib7 11790 22 and and CC cord-005453-4057qib7 11790 23 NRM NRM NNP cord-005453-4057qib7 11790 24 was be VBD cord-005453-4057qib7 11790 25 88 88 CD cord-005453-4057qib7 11790 26 % % NN cord-005453-4057qib7 11790 27 and and CC cord-005453-4057qib7 11790 28 5 5 CD cord-005453-4057qib7 11790 29 % % NN cord-005453-4057qib7 11790 30 , , , cord-005453-4057qib7 11790 31 respectively respectively RB cord-005453-4057qib7 11790 32 . . . cord-005453-4057qib7 11791 1 At at IN cord-005453-4057qib7 11791 2 6 6 CD cord-005453-4057qib7 11791 3 months month NNS cord-005453-4057qib7 11791 4 after after IN cord-005453-4057qib7 11791 5 alloHSCT alloHSCT NNP cord-005453-4057qib7 11791 6 , , , cord-005453-4057qib7 11791 7 the the DT cord-005453-4057qib7 11791 8 achievement achievement NN cord-005453-4057qib7 11791 9 of of IN cord-005453-4057qib7 11791 10 values value NNS cord-005453-4057qib7 11791 11 higher high JJR cord-005453-4057qib7 11791 12 than than IN cord-005453-4057qib7 11791 13 75 75 CD cord-005453-4057qib7 11791 14 , , , cord-005453-4057qib7 11791 15 175 175 CD cord-005453-4057qib7 11791 16 and and CC cord-005453-4057qib7 11791 17 65 65 CD cord-005453-4057qib7 11791 18 /μL /μL : cord-005453-4057qib7 11791 19 for for IN cord-005453-4057qib7 11791 20 CD4 CD4 NNP cord-005453-4057qib7 11791 21 + + CC cord-005453-4057qib7 11791 22 , , , cord-005453-4057qib7 11791 23 CD8 CD8 NNP cord-005453-4057qib7 11791 24 + + CC cord-005453-4057qib7 11791 25 and and CC cord-005453-4057qib7 11791 26 NK NK NNP cord-005453-4057qib7 11791 27 cells cell NNS cord-005453-4057qib7 11791 28 , , , cord-005453-4057qib7 11791 29 respectively respectively RB cord-005453-4057qib7 11791 30 was be VBD cord-005453-4057qib7 11791 31 significantly significantly RB cord-005453-4057qib7 11791 32 associated associate VBN cord-005453-4057qib7 11791 33 to to IN cord-005453-4057qib7 11791 34 a a DT cord-005453-4057qib7 11791 35 better well JJR cord-005453-4057qib7 11791 36 OS os NN cord-005453-4057qib7 11791 37 ( ( -LRB- cord-005453-4057qib7 11791 38 Figure figure NN cord-005453-4057qib7 11791 39 1 1 CD cord-005453-4057qib7 11791 40 ) ) -RRB- cord-005453-4057qib7 11791 41 , , , cord-005453-4057qib7 11791 42 DFS DFS NNP cord-005453-4057qib7 11791 43 ( ( -LRB- cord-005453-4057qib7 11791 44 P p NN cord-005453-4057qib7 11791 45 = = SYM cord-005453-4057qib7 11791 46 0.05 0.05 CD cord-005453-4057qib7 11791 47 ) ) -RRB- cord-005453-4057qib7 11791 48 , , , cord-005453-4057qib7 11791 49 and and CC cord-005453-4057qib7 11791 50 to to IN cord-005453-4057qib7 11791 51 a a DT cord-005453-4057qib7 11791 52 lower low JJR cord-005453-4057qib7 11791 53 NRM NRM NNP cord-005453-4057qib7 11791 54 ( ( -LRB- cord-005453-4057qib7 11791 55 P p NN cord-005453-4057qib7 11791 56 < < XX cord-005453-4057qib7 11791 57 0.001 0.001 CD cord-005453-4057qib7 11791 58 for for IN cord-005453-4057qib7 11791 59 CD4 CD4 NNP cord-005453-4057qib7 11791 60 + + CC cord-005453-4057qib7 11791 61 and and CC cord-005453-4057qib7 11791 62 CD8 CD8 NNP cord-005453-4057qib7 11791 63 + + SYM cord-005453-4057qib7 11791 64 , , , cord-005453-4057qib7 11791 65 P= P= NNP cord-005453-4057qib7 11791 66 0.0034 0.0034 CD cord-005453-4057qib7 11791 67 for for IN cord-005453-4057qib7 11791 68 NK NK NNP cord-005453-4057qib7 11791 69 ) ) -RRB- cord-005453-4057qib7 11791 70 . . . cord-005453-4057qib7 11792 1 A a DT cord-005453-4057qib7 11792 2 better well JJR cord-005453-4057qib7 11792 3 lymphoid lymphoid JJ cord-005453-4057qib7 11792 4 reconstitution reconstitution NN cord-005453-4057qib7 11792 5 was be VBD cord-005453-4057qib7 11792 6 observed observe VBN cord-005453-4057qib7 11792 7 after after IN cord-005453-4057qib7 11792 8 the the DT cord-005453-4057qib7 11792 9 use use NN cord-005453-4057qib7 11792 10 of of IN cord-005453-4057qib7 11792 11 either either CC cord-005453-4057qib7 11792 12 a a DT cord-005453-4057qib7 11792 13 sibling sibling NN cord-005453-4057qib7 11792 14 or or CC cord-005453-4057qib7 11792 15 a a DT cord-005453-4057qib7 11792 16 haplo haplo NN cord-005453-4057qib7 11792 17 donor donor NN cord-005453-4057qib7 11792 18 than than IN cord-005453-4057qib7 11792 19 a a DT cord-005453-4057qib7 11792 20 matched match VBN cord-005453-4057qib7 11792 21 unrelated unrelated JJ cord-005453-4057qib7 11792 22 or or CC cord-005453-4057qib7 11792 23 cord cord NN cord-005453-4057qib7 11792 24 blood blood NN cord-005453-4057qib7 11792 25 donors donor NNS cord-005453-4057qib7 11792 26 . . . cord-005453-4057qib7 11793 1 The the DT cord-005453-4057qib7 11793 2 use use NN cord-005453-4057qib7 11793 3 of of IN cord-005453-4057qib7 11793 4 ATG ATG NNP cord-005453-4057qib7 11793 5 was be VBD cord-005453-4057qib7 11793 6 significantly significantly RB cord-005453-4057qib7 11793 7 associated associate VBN cord-005453-4057qib7 11793 8 with with IN cord-005453-4057qib7 11793 9 a a DT cord-005453-4057qib7 11793 10 delayed delay VBN cord-005453-4057qib7 11793 11 CD4 CD4 NNP cord-005453-4057qib7 11793 12 + + CC cord-005453-4057qib7 11793 13 recovery recovery NN cord-005453-4057qib7 11793 14 but but CC cord-005453-4057qib7 11793 15 with with IN cord-005453-4057qib7 11793 16 a a DT cord-005453-4057qib7 11793 17 faster fast JJR cord-005453-4057qib7 11793 18 NK NK NNP cord-005453-4057qib7 11793 19 cells cell NNS cord-005453-4057qib7 11793 20 reconstitution reconstitution NN cord-005453-4057qib7 11793 21 . . . cord-005453-4057qib7 11794 1 Conclusions conclusion NNS cord-005453-4057qib7 11794 2 : : : cord-005453-4057qib7 11795 1 At at IN cord-005453-4057qib7 11795 2 six six CD cord-005453-4057qib7 11795 3 months month NNS cord-005453-4057qib7 11795 4 after after IN cord-005453-4057qib7 11795 5 alloHSCT alloHSCT NNP cord-005453-4057qib7 11795 6 , , , cord-005453-4057qib7 11795 7 recovery recovery NN cord-005453-4057qib7 11795 8 of of IN cord-005453-4057qib7 11795 9 CD4 CD4 NNP cord-005453-4057qib7 11795 10 + + CC cord-005453-4057qib7 11795 11 and and CC cord-005453-4057qib7 11795 12 NK NK NNP cord-005453-4057qib7 11795 13 cells cell NNS cord-005453-4057qib7 11795 14 predicts predict VBZ cord-005453-4057qib7 11795 15 survival survival NN cord-005453-4057qib7 11795 16 . . . cord-005453-4057qib7 11796 1 Monitoring monitoring NN cord-005453-4057qib7 11796 2 of of IN cord-005453-4057qib7 11796 3 immune immune JJ cord-005453-4057qib7 11796 4 recovery recovery NN cord-005453-4057qib7 11796 5 may may MD cord-005453-4057qib7 11796 6 help help VB cord-005453-4057qib7 11796 7 to to TO cord-005453-4057qib7 11796 8 guide guide VB cord-005453-4057qib7 11796 9 pre pre VB cord-005453-4057qib7 11796 10 and and CC cord-005453-4057qib7 11796 11 post post JJ cord-005453-4057qib7 11796 12 - - JJ cord-005453-4057qib7 11796 13 transplant transplant JJ cord-005453-4057qib7 11796 14 treatment treatment NN cord-005453-4057qib7 11796 15 strategies strategy NNS cord-005453-4057qib7 11796 16 . . . cord-005453-4057qib7 11797 1 Days day NNS cord-005453-4057qib7 11797 2 infections infection NNS cord-005453-4057qib7 11797 3 and and CC cord-005453-4057qib7 11797 4 disease disease NN cord-005453-4057qib7 11797 5 control control NN cord-005453-4057qib7 11797 6 . . . cord-005453-4057qib7 11798 1 Several several JJ cord-005453-4057qib7 11798 2 groups group NNS cord-005453-4057qib7 11798 3 have have VBP cord-005453-4057qib7 11798 4 demonstrated demonstrate VBN cord-005453-4057qib7 11798 5 the the DT cord-005453-4057qib7 11798 6 independent independent JJ cord-005453-4057qib7 11798 7 prognostic prognostic JJ cord-005453-4057qib7 11798 8 value value NN cord-005453-4057qib7 11798 9 of of IN cord-005453-4057qib7 11798 10 different different JJ cord-005453-4057qib7 11798 11 lymphocyte lymphocyte NN cord-005453-4057qib7 11798 12 subpopulations subpopulation NNS cord-005453-4057qib7 11798 13 in in IN cord-005453-4057qib7 11798 14 HSCT HSCT NNP cord-005453-4057qib7 11798 15 outcomes outcome NNS cord-005453-4057qib7 11798 16 . . . cord-005453-4057qib7 11799 1 Posttransplant Posttransplant NNP cord-005453-4057qib7 11799 2 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 11800 1 ( ( -LRB- cord-005453-4057qib7 11800 2 PT PT NNP cord-005453-4057qib7 11800 3 - - HYPH cord-005453-4057qib7 11800 4 Cy Cy NNP cord-005453-4057qib7 11800 5 ) ) -RRB- cord-005453-4057qib7 11800 6 effectively effectively RB cord-005453-4057qib7 11800 7 prevents prevent VBZ cord-005453-4057qib7 11800 8 GVHD GVHD NNP cord-005453-4057qib7 11800 9 after after IN cord-005453-4057qib7 11800 10 HLA HLA NNP cord-005453-4057qib7 11800 11 - - HYPH cord-005453-4057qib7 11800 12 haploidentical haploidentical JJ cord-005453-4057qib7 11800 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 11800 14 stem stem NN cord-005453-4057qib7 11800 15 cell cell NN cord-005453-4057qib7 11800 16 transplantation transplantation NN cord-005453-4057qib7 11800 17 ( ( -LRB- cord-005453-4057qib7 11800 18 Haplo Haplo NNP cord-005453-4057qib7 11800 19 ) ) -RRB- cord-005453-4057qib7 11800 20 . . . cord-005453-4057qib7 11801 1 The the DT cord-005453-4057qib7 11801 2 use use NN cord-005453-4057qib7 11801 3 of of IN cord-005453-4057qib7 11801 4 PT PT NNP cord-005453-4057qib7 11801 5 - - HYPH cord-005453-4057qib7 11801 6 Cy Cy NNP cord-005453-4057qib7 11801 7 in in IN cord-005453-4057qib7 11801 8 HLA HLA NNP cord-005453-4057qib7 11801 9 matched match VBN cord-005453-4057qib7 11801 10 related relate VBN cord-005453-4057qib7 11801 11 ( ( -LRB- cord-005453-4057qib7 11801 12 MRD MRD NNP cord-005453-4057qib7 11801 13 ) ) -RRB- cord-005453-4057qib7 11801 14 or or CC cord-005453-4057qib7 11801 15 unrelated unrelated JJ cord-005453-4057qib7 11801 16 ( ( -LRB- cord-005453-4057qib7 11801 17 MUD mud NN cord-005453-4057qib7 11801 18 ) ) -RRB- cord-005453-4057qib7 11801 19 donors donor NNS cord-005453-4057qib7 11801 20 HSCT HSCT NNP cord-005453-4057qib7 11801 21 , , , cord-005453-4057qib7 11801 22 although although IN cord-005453-4057qib7 11801 23 less less RBR cord-005453-4057qib7 11801 24 explored explore VBN cord-005453-4057qib7 11801 25 , , , cord-005453-4057qib7 11801 26 has have VBZ cord-005453-4057qib7 11801 27 also also RB cord-005453-4057qib7 11801 28 been be VBN cord-005453-4057qib7 11801 29 introduced introduce VBN cord-005453-4057qib7 11801 30 . . . cord-005453-4057qib7 11802 1 The the DT cord-005453-4057qib7 11802 2 aim aim NN cord-005453-4057qib7 11802 3 of of IN cord-005453-4057qib7 11802 4 this this DT cord-005453-4057qib7 11802 5 study study NN cord-005453-4057qib7 11802 6 was be VBD cord-005453-4057qib7 11802 7 to to TO cord-005453-4057qib7 11802 8 compare compare VB cord-005453-4057qib7 11802 9 the the DT cord-005453-4057qib7 11802 10 early early JJ cord-005453-4057qib7 11802 11 immune immune JJ cord-005453-4057qib7 11802 12 reconstitution reconstitution NN cord-005453-4057qib7 11802 13 after after IN cord-005453-4057qib7 11802 14 allogeneic allogeneic NN cord-005453-4057qib7 11802 15 HSCT HSCT NNP cord-005453-4057qib7 11802 16 from from IN cord-005453-4057qib7 11802 17 haploidentical haploidentical JJ cord-005453-4057qib7 11802 18 and and CC cord-005453-4057qib7 11802 19 HLA HLA NNP cord-005453-4057qib7 11802 20 - - HYPH cord-005453-4057qib7 11802 21 matched match VBN cord-005453-4057qib7 11802 22 donors donor NNS cord-005453-4057qib7 11802 23 using use VBG cord-005453-4057qib7 11802 24 PT PT NNP cord-005453-4057qib7 11802 25 - - HYPH cord-005453-4057qib7 11802 26 Cy Cy NNP cord-005453-4057qib7 11802 27 . . . cord-005453-4057qib7 11803 1 Methods method NNS cord-005453-4057qib7 11803 2 : : : cord-005453-4057qib7 11804 1 One one CD cord-005453-4057qib7 11804 2 hundred hundred CD cord-005453-4057qib7 11804 3 and and CC cord-005453-4057qib7 11804 4 sixty sixty CD cord-005453-4057qib7 11804 5 - - HYPH cord-005453-4057qib7 11804 6 four four CD cord-005453-4057qib7 11804 7 HSCT HSCT NNP cord-005453-4057qib7 11804 8 performed perform VBN cord-005453-4057qib7 11804 9 in in IN cord-005453-4057qib7 11804 10 our -PRON- PRP$ cord-005453-4057qib7 11804 11 center center NN cord-005453-4057qib7 11804 12 were be VBD cord-005453-4057qib7 11804 13 analyzed analyze VBN cord-005453-4057qib7 11804 14 : : : cord-005453-4057qib7 11804 15 125 125 CD cord-005453-4057qib7 11804 16 Haplo Haplo NNP cord-005453-4057qib7 11804 17 performed perform VBN cord-005453-4057qib7 11804 18 between between IN cord-005453-4057qib7 11804 19 2011 2011 CD cord-005453-4057qib7 11804 20 and and CC cord-005453-4057qib7 11804 21 2017 2017 CD cord-005453-4057qib7 11804 22 and and CC cord-005453-4057qib7 11804 23 39 39 CD cord-005453-4057qib7 11804 24 HSCT HSCT NNP cord-005453-4057qib7 11804 25 from from IN cord-005453-4057qib7 11804 26 HLA HLA NNP cord-005453-4057qib7 11804 27 - - HYPH cord-005453-4057qib7 11804 28 identical identical JJ cord-005453-4057qib7 11804 29 donors donor NNS cord-005453-4057qib7 11804 30 ( ( -LRB- cord-005453-4057qib7 11804 31 19 19 CD cord-005453-4057qib7 11804 32 consecutive consecutive JJ cord-005453-4057qib7 11804 33 MRD MRD NNP cord-005453-4057qib7 11804 34 SCT SCT NNP cord-005453-4057qib7 11804 35 performed perform VBN cord-005453-4057qib7 11804 36 with with IN cord-005453-4057qib7 11804 37 PT PT NNP cord-005453-4057qib7 11804 38 - - HYPH cord-005453-4057qib7 11804 39 Cy Cy NNP cord-005453-4057qib7 11804 40 between between IN cord-005453-4057qib7 11804 41 2016 2016 CD cord-005453-4057qib7 11804 42 and and CC cord-005453-4057qib7 11804 43 2017 2017 CD cord-005453-4057qib7 11804 44 and and CC cord-005453-4057qib7 11804 45 20 20 CD cord-005453-4057qib7 11804 46 MUD mud NN cord-005453-4057qib7 11804 47 SCT SCT NNP cord-005453-4057qib7 11804 48 with with IN cord-005453-4057qib7 11804 49 PT PT NNP cord-005453-4057qib7 11804 50 - - HYPH cord-005453-4057qib7 11804 51 CY CY NNP cord-005453-4057qib7 11804 52 between between IN cord-005453-4057qib7 11804 53 2014 2014 CD cord-005453-4057qib7 11804 54 and and CC cord-005453-4057qib7 11804 55 2017 2017 CD cord-005453-4057qib7 11804 56 ) ) -RRB- cord-005453-4057qib7 11804 57 . . . cord-005453-4057qib7 11805 1 PT PT NNP cord-005453-4057qib7 11805 2 - - HYPH cord-005453-4057qib7 11805 3 Cy Cy NNP cord-005453-4057qib7 11805 4 was be VBD cord-005453-4057qib7 11805 5 administered administer VBN cord-005453-4057qib7 11805 6 at at IN cord-005453-4057qib7 11805 7 50mg 50mg CD cord-005453-4057qib7 11805 8 / / SYM cord-005453-4057qib7 11805 9 kg kg NN cord-005453-4057qib7 11805 10 / / SYM cord-005453-4057qib7 11805 11 d d NN cord-005453-4057qib7 11805 12 in in IN cord-005453-4057qib7 11805 13 days day NNS cord-005453-4057qib7 11805 14 +3 +3 NNP cord-005453-4057qib7 11805 15 and and CC cord-005453-4057qib7 11805 16 +4 +4 NNP cord-005453-4057qib7 11805 17 postransplant postransplant NN cord-005453-4057qib7 11805 18 , , , cord-005453-4057qib7 11805 19 followed follow VBN cord-005453-4057qib7 11805 20 by by IN cord-005453-4057qib7 11805 21 MMF MMF NNP cord-005453-4057qib7 11805 22 10mg 10mg NNP cord-005453-4057qib7 11805 23 / / SYM cord-005453-4057qib7 11805 24 kg/ kg/ NNP cord-005453-4057qib7 11805 25 d d NNP cord-005453-4057qib7 11805 26 and and CC cord-005453-4057qib7 11805 27 a a DT cord-005453-4057qib7 11805 28 calcineurin calcineurin JJ cord-005453-4057qib7 11805 29 inhibitor inhibitor NN cord-005453-4057qib7 11806 1 ( ( -LRB- cord-005453-4057qib7 11806 2 Ciclosporina Ciclosporina NNP cord-005453-4057qib7 11806 3 A A NNP cord-005453-4057qib7 11806 4 or or CC cord-005453-4057qib7 11806 5 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 11806 6 ) ) -RRB- cord-005453-4057qib7 11806 7 from from IN cord-005453-4057qib7 11806 8 day day NN cord-005453-4057qib7 11806 9 +5 +5 NFP cord-005453-4057qib7 11806 10 ahead ahead RB cord-005453-4057qib7 11806 11 . . . cord-005453-4057qib7 11807 1 We -PRON- PRP cord-005453-4057qib7 11807 2 retrospectively retrospectively RB cord-005453-4057qib7 11807 3 compared compare VBD cord-005453-4057qib7 11807 4 early early JJ cord-005453-4057qib7 11807 5 immune immune JJ cord-005453-4057qib7 11807 6 reconstitution reconstitution NN cord-005453-4057qib7 11807 7 at at IN cord-005453-4057qib7 11807 8 day day NN cord-005453-4057qib7 11807 9 +30 +30 CD cord-005453-4057qib7 11807 10 and and CC cord-005453-4057qib7 11807 11 day day NN cord-005453-4057qib7 11807 12 +90 +90 CD cord-005453-4057qib7 11807 13 among among IN cord-005453-4057qib7 11807 14 these these DT cord-005453-4057qib7 11807 15 three three CD cord-005453-4057qib7 11807 16 populations population NNS cord-005453-4057qib7 11807 17 . . . cord-005453-4057qib7 11808 1 Early early RB cord-005453-4057qib7 11808 2 IR IR NNP cord-005453-4057qib7 11808 3 was be VBD cord-005453-4057qib7 11808 4 assessed assess VBN cord-005453-4057qib7 11808 5 through through IN cord-005453-4057qib7 11808 6 the the DT cord-005453-4057qib7 11808 7 analysis analysis NN cord-005453-4057qib7 11808 8 of of IN cord-005453-4057qib7 11808 9 lymphocyte lymphocyte NN cord-005453-4057qib7 11808 10 subpopulations subpopulation NNS cord-005453-4057qib7 11808 11 including include VBG cord-005453-4057qib7 11808 12 total total JJ cord-005453-4057qib7 11808 13 T t NN cord-005453-4057qib7 11808 14 lymphocytes lymphocyte NNS cord-005453-4057qib7 11808 15 CD3 CD3 NNP cord-005453-4057qib7 11808 16 + + CC cord-005453-4057qib7 11808 17 , , , cord-005453-4057qib7 11808 18 CD4 CD4 NNP cord-005453-4057qib7 11808 19 + + CC cord-005453-4057qib7 11808 20 and and CC cord-005453-4057qib7 11808 21 CD8+subpopulations cd8+subpopulation NNS cord-005453-4057qib7 11808 22 , , , cord-005453-4057qib7 11808 23 NK NK NNP cord-005453-4057qib7 11808 24 CD3-CD56 cd3-cd56 NN cord-005453-4057qib7 11808 25 + + CC cord-005453-4057qib7 11808 26 cells cell NNS cord-005453-4057qib7 11808 27 , , , cord-005453-4057qib7 11808 28 CD56 cd56 NN cord-005453-4057qib7 11808 29 + + CC cord-005453-4057qib7 11808 30 bright bright JJ cord-005453-4057qib7 11808 31 immature immature JJ cord-005453-4057qib7 11808 32 subpopulation subpopulation NN cord-005453-4057qib7 11808 33 and and CC cord-005453-4057qib7 11808 34 total total NN cord-005453-4057qib7 11808 35 B b NN cord-005453-4057qib7 11808 36 CD19 CD19 NNP cord-005453-4057qib7 11809 1 + + CC cord-005453-4057qib7 11809 2 lymphocytes lymphocyte NNS cord-005453-4057qib7 11809 3 .. .. . cord-005453-4057qib7 11810 1 Lymphocytes lymphocytes NN cord-005453-4057qib7 11810 2 subpopulations subpopulation NNS cord-005453-4057qib7 11810 3 were be VBD cord-005453-4057qib7 11810 4 determined determine VBN cord-005453-4057qib7 11810 5 by by IN cord-005453-4057qib7 11810 6 multiparametric multiparametric JJ cord-005453-4057qib7 11810 7 flow flow NN cord-005453-4057qib7 11810 8 cytometry cytometry NN cord-005453-4057qib7 11810 9 ( ( -LRB- cord-005453-4057qib7 11810 10 FC500 FC500 NNP cord-005453-4057qib7 11810 11 and and CC cord-005453-4057qib7 11810 12 Navios Navios NNP cord-005453-4057qib7 11810 13 , , , cord-005453-4057qib7 11810 14 Beckman Beckman NNP cord-005453-4057qib7 11810 15 Coulter Coulter NNP cord-005453-4057qib7 11810 16 ® ® POS cord-005453-4057qib7 11810 17 ) ) -RRB- cord-005453-4057qib7 11810 18 . . . cord-005453-4057qib7 11811 1 Results result NNS cord-005453-4057qib7 11811 2 : : : cord-005453-4057qib7 11812 1 All all DT cord-005453-4057qib7 11812 2 patients patient NNS cord-005453-4057qib7 11812 3 , , , cord-005453-4057qib7 11812 4 but but CC cord-005453-4057qib7 11812 5 1 1 CD cord-005453-4057qib7 11812 6 MUD mud NN cord-005453-4057qib7 11812 7 and and CC cord-005453-4057qib7 11812 8 1 1 CD cord-005453-4057qib7 11812 9 Haplo Haplo NNP cord-005453-4057qib7 11812 10 , , , cord-005453-4057qib7 11812 11 received receive VBD cord-005453-4057qib7 11812 12 PB PB NNP cord-005453-4057qib7 11812 13 as as IN cord-005453-4057qib7 11812 14 stem stem NN cord-005453-4057qib7 11812 15 cell cell NN cord-005453-4057qib7 11812 16 source source NN cord-005453-4057qib7 11812 17 . . . cord-005453-4057qib7 11813 1 46 46 CD cord-005453-4057qib7 11813 2 patients patient NNS cord-005453-4057qib7 11813 3 received receive VBD cord-005453-4057qib7 11813 4 prior prior JJ cord-005453-4057qib7 11813 5 transplant transplant NN cord-005453-4057qib7 11813 6 in in IN cord-005453-4057qib7 11813 7 Haplo Haplo NNP cord-005453-4057qib7 11813 8 group group NN cord-005453-4057qib7 11813 9 . . . cord-005453-4057qib7 11814 1 Patient´s patient´s JJ cord-005453-4057qib7 11814 2 characteristics characteristic NNS cord-005453-4057qib7 11814 3 are be VBP cord-005453-4057qib7 11814 4 shown show VBN cord-005453-4057qib7 11814 5 in in IN cord-005453-4057qib7 11814 6 table table NN cord-005453-4057qib7 11814 7 1 1 CD cord-005453-4057qib7 11814 8 . . . cord-005453-4057qib7 11815 1 Patients patient NNS cord-005453-4057qib7 11815 2 who who WP cord-005453-4057qib7 11815 3 received receive VBD cord-005453-4057qib7 11815 4 HSCT HSCT NNP cord-005453-4057qib7 11815 5 from from IN cord-005453-4057qib7 11815 6 MRD MRD NNP cord-005453-4057qib7 11815 7 showed show VBD cord-005453-4057qib7 11815 8 the the DT cord-005453-4057qib7 11815 9 fastest fast JJS cord-005453-4057qib7 11815 10 IR IR NNP cord-005453-4057qib7 11815 11 , , , cord-005453-4057qib7 11815 12 with with IN cord-005453-4057qib7 11815 13 statistically statistically RB cord-005453-4057qib7 11815 14 significant significant JJ cord-005453-4057qib7 11815 15 differences difference NNS cord-005453-4057qib7 11815 16 compared compare VBN cord-005453-4057qib7 11815 17 to to IN cord-005453-4057qib7 11815 18 Haplo Haplo NNP cord-005453-4057qib7 11815 19 in in IN cord-005453-4057qib7 11815 20 almost almost RB cord-005453-4057qib7 11815 21 all all DT cord-005453-4057qib7 11815 22 lymphocyte lymphocyte NN cord-005453-4057qib7 11815 23 populations population NNS cord-005453-4057qib7 11815 24 at at IN cord-005453-4057qib7 11815 25 day day NN cord-005453-4057qib7 11815 26 +30 +30 CD cord-005453-4057qib7 11815 27 ( ( -LRB- cord-005453-4057qib7 11815 28 CD3 CD3 NNP cord-005453-4057qib7 11815 29 + + CC cord-005453-4057qib7 11815 30 , , , cord-005453-4057qib7 11815 31 CD4 CD4 NNP cord-005453-4057qib7 11815 32 + + CC cord-005453-4057qib7 11815 33 , , , cord-005453-4057qib7 11815 34 CD8 CD8 NNP cord-005453-4057qib7 11815 35 + + CC cord-005453-4057qib7 11815 36 and and CC cord-005453-4057qib7 11815 37 NK NK NNP cord-005453-4057qib7 11815 38 cells cell NNS cord-005453-4057qib7 11815 39 ) ) -RRB- cord-005453-4057qib7 11815 40 , , , cord-005453-4057qib7 11815 41 and and CC cord-005453-4057qib7 11815 42 also also RB cord-005453-4057qib7 11815 43 in in IN cord-005453-4057qib7 11815 44 CD3 CD3 NNP cord-005453-4057qib7 11816 1 + + CC cord-005453-4057qib7 11816 2 , , , cord-005453-4057qib7 11816 3 CD8 CD8 NNP cord-005453-4057qib7 11816 4 + + CC cord-005453-4057qib7 11816 5 and and CC cord-005453-4057qib7 11816 6 B b NN cord-005453-4057qib7 11816 7 lymphocytes lymphocyte NNS cord-005453-4057qib7 11816 8 at at IN cord-005453-4057qib7 11816 9 day day NN cord-005453-4057qib7 11816 10 +90 +90 CD cord-005453-4057qib7 11816 11 . . . cord-005453-4057qib7 11817 1 Comparison comparison NN cord-005453-4057qib7 11817 2 between between IN cord-005453-4057qib7 11817 3 Haplo Haplo NNP cord-005453-4057qib7 11817 4 and and CC cord-005453-4057qib7 11817 5 MUD MUD NNP cord-005453-4057qib7 11817 6 HSCT HSCT NNP cord-005453-4057qib7 11817 7 showed show VBD cord-005453-4057qib7 11817 8 better well JJR cord-005453-4057qib7 11817 9 IR IR NNP cord-005453-4057qib7 11817 10 among among IN cord-005453-4057qib7 11817 11 Haplo Haplo NNP cord-005453-4057qib7 11817 12 , , , cord-005453-4057qib7 11817 13 demonstrated demonstrate VBN cord-005453-4057qib7 11817 14 by by IN cord-005453-4057qib7 11817 15 higher high JJR cord-005453-4057qib7 11817 16 counts count NNS cord-005453-4057qib7 11817 17 in in IN cord-005453-4057qib7 11817 18 CD3+,CD4 CD3+,CD4 NNP cord-005453-4057qib7 11818 1 + + CC cord-005453-4057qib7 11818 2 , , , cord-005453-4057qib7 11818 3 CD8 CD8 NNP cord-005453-4057qib7 11818 4 + + CC cord-005453-4057qib7 11818 5 and and CC cord-005453-4057qib7 11818 6 NK NK NNP cord-005453-4057qib7 11818 7 cell cell NN cord-005453-4057qib7 11818 8 counts count VBZ cord-005453-4057qib7 11818 9 at at IN cord-005453-4057qib7 11818 10 day day NN cord-005453-4057qib7 11818 11 +30 +30 CD cord-005453-4057qib7 11818 12 . . . cord-005453-4057qib7 11819 1 No no DT cord-005453-4057qib7 11819 2 differences difference NNS cord-005453-4057qib7 11819 3 were be VBD cord-005453-4057qib7 11819 4 seen see VBN cord-005453-4057qib7 11819 5 at at IN cord-005453-4057qib7 11819 6 day day NN cord-005453-4057qib7 11819 7 +90 +90 CD cord-005453-4057qib7 11819 8 . . . cord-005453-4057qib7 11820 1 ( ( -LRB- cord-005453-4057qib7 11820 2 Figure figure NN cord-005453-4057qib7 11820 3 1 1 CD cord-005453-4057qib7 11820 4 ) ) -RRB- cord-005453-4057qib7 11820 5 . . . cord-005453-4057qib7 11821 1 Percentage percentage NN cord-005453-4057qib7 11821 2 of of IN cord-005453-4057qib7 11821 3 immature immature JJ cord-005453-4057qib7 11821 4 CD56 CD56 NNP cord-005453-4057qib7 11821 5 bright bright JJ cord-005453-4057qib7 11821 6 NK NK NNP cord-005453-4057qib7 11821 7 cells cell NNS cord-005453-4057qib7 11821 8 was be VBD cord-005453-4057qib7 11821 9 higher high JJR cord-005453-4057qib7 11821 10 in in IN cord-005453-4057qib7 11821 11 MUD mud NN cord-005453-4057qib7 11821 12 HSCT HSCT NNP cord-005453-4057qib7 11821 13 at at IN cord-005453-4057qib7 11821 14 +30 +30 CD cord-005453-4057qib7 11821 15 , , , cord-005453-4057qib7 11821 16 with with IN cord-005453-4057qib7 11821 17 no no DT cord-005453-4057qib7 11821 18 differences difference NNS cord-005453-4057qib7 11821 19 between between IN cord-005453-4057qib7 11821 20 Haplo Haplo NNP cord-005453-4057qib7 11821 21 and and CC cord-005453-4057qib7 11821 22 MRD MRD NNP cord-005453-4057qib7 11821 23 HSCT HSCT NNP cord-005453-4057qib7 11821 24 . . . cord-005453-4057qib7 11822 1 Conclusions conclusion NNS cord-005453-4057qib7 11822 2 : : : cord-005453-4057qib7 11823 1 In in IN cord-005453-4057qib7 11823 2 our -PRON- PRP$ cord-005453-4057qib7 11823 3 cohort cohort NN cord-005453-4057qib7 11823 4 of of IN cord-005453-4057qib7 11823 5 patients patient NNS cord-005453-4057qib7 11823 6 with with IN cord-005453-4057qib7 11823 7 PT PT NNP cord-005453-4057qib7 11823 8 - - HYPH cord-005453-4057qib7 11823 9 CY CY NNP cord-005453-4057qib7 11823 10 based base VBN cord-005453-4057qib7 11823 11 GVHD GVHD NNP cord-005453-4057qib7 11823 12 prophylaxis prophylaxis JJ cord-005453-4057qib7 11823 13 regimen regimen NN cord-005453-4057qib7 11823 14 , , , cord-005453-4057qib7 11823 15 those those DT cord-005453-4057qib7 11823 16 who who WP cord-005453-4057qib7 11823 17 received receive VBD cord-005453-4057qib7 11823 18 HSCT HSCT NNP cord-005453-4057qib7 11823 19 from from IN cord-005453-4057qib7 11823 20 MRD MRD NNP cord-005453-4057qib7 11823 21 showed show VBD cord-005453-4057qib7 11823 22 the the DT cord-005453-4057qib7 11823 23 earliest early JJS cord-005453-4057qib7 11823 24 immune immune JJ cord-005453-4057qib7 11823 25 reconstitution reconstitution NN cord-005453-4057qib7 11823 26 compared compare VBN cord-005453-4057qib7 11823 27 to to IN cord-005453-4057qib7 11823 28 Haplo Haplo NNP cord-005453-4057qib7 11823 29 and and CC cord-005453-4057qib7 11823 30 MUD MUD NNP cord-005453-4057qib7 11823 31 at at IN cord-005453-4057qib7 11823 32 day day NN cord-005453-4057qib7 11823 33 +30 +30 CD cord-005453-4057qib7 11823 34 and and CC cord-005453-4057qib7 11823 35 +90 +90 NN cord-005453-4057qib7 11823 36 . . . cord-005453-4057qib7 11824 1 Haplo Haplo NNP cord-005453-4057qib7 11824 2 showed show VBD cord-005453-4057qib7 11824 3 better well JJR cord-005453-4057qib7 11824 4 IR IR NNP cord-005453-4057qib7 11824 5 compared compare VBN cord-005453-4057qib7 11824 6 to to IN cord-005453-4057qib7 11824 7 MUD mud NN cord-005453-4057qib7 11824 8 at at IN cord-005453-4057qib7 11824 9 day day NN cord-005453-4057qib7 11824 10 +30 +30 CD cord-005453-4057qib7 11824 11 . . . cord-005453-4057qib7 11825 1 NK NK NNP cord-005453-4057qib7 11825 2 maturation maturation NN cord-005453-4057qib7 11825 3 at at IN cord-005453-4057qib7 11825 4 day day NN cord-005453-4057qib7 11825 5 +30 +30 CD cord-005453-4057qib7 11825 6 was be VBD cord-005453-4057qib7 11825 7 a a DT cord-005453-4057qib7 11825 8 little little JJ cord-005453-4057qib7 11825 9 better well JJR cord-005453-4057qib7 11825 10 among among IN cord-005453-4057qib7 11825 11 Haplo Haplo NNP cord-005453-4057qib7 11825 12 and and CC cord-005453-4057qib7 11825 13 MRD MRD NNP cord-005453-4057qib7 11825 14 HSCT HSCT NNP cord-005453-4057qib7 11825 15 recipients recipient NNS cord-005453-4057qib7 11825 16 than than IN cord-005453-4057qib7 11825 17 MUD mud NN cord-005453-4057qib7 11825 18 HSCT HSCT NNP cord-005453-4057qib7 11825 19 patients patient NNS cord-005453-4057qib7 11825 20 . . . cord-005453-4057qib7 11826 1 In in IN cord-005453-4057qib7 11826 2 our -PRON- PRP$ cord-005453-4057qib7 11826 3 experience experience NN cord-005453-4057qib7 11826 4 , , , cord-005453-4057qib7 11826 5 using use VBG cord-005453-4057qib7 11826 6 mostly mostly RB cord-005453-4057qib7 11826 7 PBSC PBSC NNP cord-005453-4057qib7 11826 8 as as IN cord-005453-4057qib7 11826 9 graft graft NN cord-005453-4057qib7 11826 10 source source NN cord-005453-4057qib7 11826 11 , , , cord-005453-4057qib7 11826 12 type type NN cord-005453-4057qib7 11826 13 of of IN cord-005453-4057qib7 11826 14 donor donor NN cord-005453-4057qib7 11826 15 influenced influence VBN cord-005453-4057qib7 11826 16 early early JJ cord-005453-4057qib7 11826 17 IR IR NNP cord-005453-4057qib7 11826 18 in in IN cord-005453-4057qib7 11826 19 PT PT NNP cord-005453-4057qib7 11826 20 - - HYPH cord-005453-4057qib7 11826 21 Cy Cy NNP cord-005453-4057qib7 11826 22 based base VBN cord-005453-4057qib7 11826 23 HSCT HSCT NNP cord-005453-4057qib7 11826 24 , , , cord-005453-4057qib7 11826 25 Background background NN cord-005453-4057qib7 11826 26 : : : cord-005453-4057qib7 11826 27 Cell cell NN cord-005453-4057qib7 11826 28 - - HYPH cord-005453-4057qib7 11826 29 free free JJ cord-005453-4057qib7 11826 30 DNA dna NN cord-005453-4057qib7 11826 31 ( ( -LRB- cord-005453-4057qib7 11826 32 cfDNA cfDNA VBG cord-005453-4057qib7 11826 33 ) ) -RRB- cord-005453-4057qib7 11826 34 isolated isolate VBN cord-005453-4057qib7 11826 35 from from IN cord-005453-4057qib7 11826 36 plasma plasma NN cord-005453-4057qib7 11826 37 or or CC cord-005453-4057qib7 11826 38 serum serum NN cord-005453-4057qib7 11826 39 has have VBZ cord-005453-4057qib7 11826 40 received receive VBN cord-005453-4057qib7 11826 41 increasing increase VBG cord-005453-4057qib7 11826 42 interest interest NN cord-005453-4057qib7 11826 43 for for IN cord-005453-4057qib7 11826 44 diagnostic diagnostic JJ cord-005453-4057qib7 11826 45 applications application NNS cord-005453-4057qib7 11826 46 . . . cord-005453-4057qib7 11827 1 However however RB cord-005453-4057qib7 11827 2 , , , cord-005453-4057qib7 11827 3 the the DT cord-005453-4057qib7 11827 4 reported report VBN cord-005453-4057qib7 11827 5 clinical clinical JJ cord-005453-4057qib7 11827 6 usefulness usefulness NN cord-005453-4057qib7 11827 7 of of IN cord-005453-4057qib7 11827 8 cfDNA cfdna RB cord-005453-4057qib7 11827 9 in in IN cord-005453-4057qib7 11827 10 patients patient NNS cord-005453-4057qib7 11827 11 undergoing undergo VBG cord-005453-4057qib7 11827 12 allogeneic allogeneic IN cord-005453-4057qib7 11827 13 cell cell NN cord-005453-4057qib7 11827 14 transplantation transplantation NN cord-005453-4057qib7 11827 15 ( ( -LRB- cord-005453-4057qib7 11827 16 HSCT HSCT NNP cord-005453-4057qib7 11827 17 ) ) -RRB- cord-005453-4057qib7 11827 18 is be VBZ cord-005453-4057qib7 11827 19 scarce scarce JJ cord-005453-4057qib7 11827 20 . . . cord-005453-4057qib7 11828 1 Methods method NNS cord-005453-4057qib7 11828 2 : : : cord-005453-4057qib7 11828 3 The the DT cord-005453-4057qib7 11828 4 chimeric chimeric JJ cord-005453-4057qib7 11828 5 status status NN cord-005453-4057qib7 11828 6 both both CC cord-005453-4057qib7 11828 7 in in IN cord-005453-4057qib7 11828 8 peripheral peripheral JJ cord-005453-4057qib7 11828 9 blood blood NN cord-005453-4057qib7 11828 10 and and CC cord-005453-4057qib7 11828 11 in in IN cord-005453-4057qib7 11828 12 cfDNA cfdna RB cord-005453-4057qib7 11828 13 obtained obtain VBN cord-005453-4057qib7 11828 14 from from IN cord-005453-4057qib7 11828 15 plasma plasma NN cord-005453-4057qib7 11828 16 was be VBD cord-005453-4057qib7 11828 17 investigated investigate VBN cord-005453-4057qib7 11828 18 in in IN cord-005453-4057qib7 11828 19 110 110 CD cord-005453-4057qib7 11828 20 patients patient NNS cord-005453-4057qib7 11828 21 undergoing undergo VBG cord-005453-4057qib7 11828 22 HSCT HSCT NNP cord-005453-4057qib7 11828 23 . . . cord-005453-4057qib7 11829 1 DNA DNA NNP cord-005453-4057qib7 11829 2 and and CC cord-005453-4057qib7 11829 3 RNA RNA NNP cord-005453-4057qib7 11829 4 were be VBD cord-005453-4057qib7 11829 5 isolated isolate VBN cord-005453-4057qib7 11829 6 from from IN cord-005453-4057qib7 11829 7 plasma plasma NN cord-005453-4057qib7 11829 8 within within IN cord-005453-4057qib7 11829 9 four four CD cord-005453-4057qib7 11829 10 hours hour NNS cord-005453-4057qib7 11829 11 of of IN cord-005453-4057qib7 11829 12 blood blood NN cord-005453-4057qib7 11829 13 draw draw NN cord-005453-4057qib7 11829 14 . . . cord-005453-4057qib7 11830 1 Patients patient NNS cord-005453-4057qib7 11830 2 were be VBD cord-005453-4057qib7 11830 3 evaluated evaluate VBN cord-005453-4057qib7 11830 4 for for IN cord-005453-4057qib7 11830 5 chimerism chimerism NN cord-005453-4057qib7 11830 6 at at IN cord-005453-4057qib7 11830 7 day day NN cord-005453-4057qib7 11830 8 +30 +30 CD cord-005453-4057qib7 11830 9 , , , cord-005453-4057qib7 11830 10 +100 +100 NNP cord-005453-4057qib7 11830 11 and and CC cord-005453-4057qib7 11830 12 +365 +365 NNP cord-005453-4057qib7 11830 13 post post NN cord-005453-4057qib7 11830 14 - - NN cord-005453-4057qib7 11830 15 transplant transplant NN cord-005453-4057qib7 11830 16 . . . cord-005453-4057qib7 11831 1 A a DT cord-005453-4057qib7 11831 2 panel panel NN cord-005453-4057qib7 11831 3 of of IN cord-005453-4057qib7 11831 4 seven seven CD cord-005453-4057qib7 11831 5 microsatellites microsatellite NNS cord-005453-4057qib7 11831 6 was be VBD cord-005453-4057qib7 11831 7 amplified amplify VBN cord-005453-4057qib7 11831 8 by by IN cord-005453-4057qib7 11831 9 PCR PCR NNP cord-005453-4057qib7 11831 10 for for IN cord-005453-4057qib7 11831 11 chimerism chimerism NN cord-005453-4057qib7 11831 12 detection detection NN cord-005453-4057qib7 11831 13 and and CC cord-005453-4057qib7 11831 14 PCR PCR NNP cord-005453-4057qib7 11831 15 products product NNS cord-005453-4057qib7 11831 16 were be VBD cord-005453-4057qib7 11831 17 analysed analyse VBN cord-005453-4057qib7 11831 18 by by IN cord-005453-4057qib7 11831 19 capillary capillary JJ cord-005453-4057qib7 11831 20 electrophoresis electrophoresis NN cord-005453-4057qib7 11831 21 . . . cord-005453-4057qib7 11832 1 For for IN cord-005453-4057qib7 11832 2 further further JJ cord-005453-4057qib7 11832 3 cfDNA cfDNA JJR cord-005453-4057qib7 11832 4 characterization characterization NN cord-005453-4057qib7 11832 5 the the DT cord-005453-4057qib7 11832 6 micro micro NNP cord-005453-4057qib7 11832 7 RNA RNA NNP cord-005453-4057qib7 11832 8 ( ( -LRB- cord-005453-4057qib7 11832 9 miRNA miRNA NNP cord-005453-4057qib7 11832 10 ) ) -RRB- cord-005453-4057qib7 11832 11 200c 200c NNP cord-005453-4057qib7 11832 12 was be VBD cord-005453-4057qib7 11832 13 analysed analyse VBN cord-005453-4057qib7 11832 14 using use VBG cord-005453-4057qib7 11832 15 digital digital JJ cord-005453-4057qib7 11832 16 PCR PCR NNP cord-005453-4057qib7 11832 17 . . . cord-005453-4057qib7 11833 1 Mutations mutation NNS cord-005453-4057qib7 11833 2 frequently frequently RB cord-005453-4057qib7 11833 3 used use VBD cord-005453-4057qib7 11833 4 for for IN cord-005453-4057qib7 11833 5 minimal minimal JJ cord-005453-4057qib7 11833 6 residual residual JJ cord-005453-4057qib7 11833 7 disease disease NN cord-005453-4057qib7 11833 8 assessment assessment NN cord-005453-4057qib7 11833 9 such such JJ cord-005453-4057qib7 11833 10 as as IN cord-005453-4057qib7 11833 11 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 11833 12 , , , cord-005453-4057qib7 11833 13 NPM1 NPM1 NNP cord-005453-4057qib7 11833 14 and and CC cord-005453-4057qib7 11833 15 JAK2 JAK2 NNP cord-005453-4057qib7 11833 16 were be VBD cord-005453-4057qib7 11833 17 also also RB cord-005453-4057qib7 11833 18 investigated investigate VBN cord-005453-4057qib7 11833 19 in in IN cord-005453-4057qib7 11833 20 cfDNA cfdna ADD cord-005453-4057qib7 11833 21 . . . cord-005453-4057qib7 11834 1 Results result NNS cord-005453-4057qib7 11834 2 : : : cord-005453-4057qib7 11835 1 The the DT cord-005453-4057qib7 11835 2 mean mean NN cord-005453-4057qib7 11835 3 cfDNA cfdna JJ cord-005453-4057qib7 11835 4 concentration concentration NN cord-005453-4057qib7 11835 5 in in IN cord-005453-4057qib7 11835 6 transplanted transplanted JJ cord-005453-4057qib7 11835 7 patients patient NNS cord-005453-4057qib7 11835 8 was be VBD cord-005453-4057qib7 11835 9 469 469 CD cord-005453-4057qib7 11835 10 ng ng NNP cord-005453-4057qib7 11835 11 / / SYM cord-005453-4057qib7 11835 12 ml ml XX cord-005453-4057qib7 11835 13 , , , cord-005453-4057qib7 11835 14 while while IN cord-005453-4057qib7 11835 15 in in IN cord-005453-4057qib7 11835 16 healthy healthy JJ cord-005453-4057qib7 11835 17 donors donor NNS cord-005453-4057qib7 11835 18 used use VBN cord-005453-4057qib7 11835 19 as as IN cord-005453-4057qib7 11835 20 control control NN cord-005453-4057qib7 11835 21 group group NN cord-005453-4057qib7 11835 22 ( ( -LRB- cord-005453-4057qib7 11835 23 n=20 n=20 NNP cord-005453-4057qib7 11835 24 ) ) -RRB- cord-005453-4057qib7 11835 25 was be VBD cord-005453-4057qib7 11835 26 119 119 CD cord-005453-4057qib7 11835 27 ng ng NN cord-005453-4057qib7 11835 28 / / SYM cord-005453-4057qib7 11835 29 ml ml NN cord-005453-4057qib7 11835 30 . . . cord-005453-4057qib7 11836 1 The the DT cord-005453-4057qib7 11836 2 mean mean NN cord-005453-4057qib7 11836 3 cfDNA cfdna JJ cord-005453-4057qib7 11836 4 concentration concentration NN cord-005453-4057qib7 11836 5 difference difference NN cord-005453-4057qib7 11836 6 between between IN cord-005453-4057qib7 11836 7 both both DT cord-005453-4057qib7 11836 8 groups group NNS cord-005453-4057qib7 11836 9 reached reach VBD cord-005453-4057qib7 11836 10 statistical statistical JJ cord-005453-4057qib7 11836 11 significance significance NN cord-005453-4057qib7 11836 12 ( ( -LRB- cord-005453-4057qib7 11836 13 p= p= NNP cord-005453-4057qib7 11836 14 0.0197 0.0197 CD cord-005453-4057qib7 11836 15 ) ) -RRB- cord-005453-4057qib7 11836 16 . . . cord-005453-4057qib7 11837 1 When when WRB cord-005453-4057qib7 11837 2 analysing analyse VBG cord-005453-4057qib7 11837 3 cfDNA cfdna RB cord-005453-4057qib7 11837 4 from from IN cord-005453-4057qib7 11837 5 transplanted transplanted JJ cord-005453-4057qib7 11837 6 patients patient NNS cord-005453-4057qib7 11837 7 and and CC cord-005453-4057qib7 11837 8 in in IN cord-005453-4057qib7 11837 9 the the DT cord-005453-4057qib7 11837 10 control control NN cord-005453-4057qib7 11837 11 group group NN cord-005453-4057qib7 11837 12 we -PRON- PRP cord-005453-4057qib7 11837 13 could could MD cord-005453-4057qib7 11837 14 not not RB cord-005453-4057qib7 11837 15 detect detect VB cord-005453-4057qib7 11837 16 DNA dna NN cord-005453-4057qib7 11837 17 fragments fragment NNS cord-005453-4057qib7 11837 18 larger large JJR cord-005453-4057qib7 11837 19 than than IN cord-005453-4057qib7 11837 20 400 400 CD cord-005453-4057qib7 11837 21 bp bp NNS cord-005453-4057qib7 11837 22 and and CC cord-005453-4057qib7 11838 1 the the DT cord-005453-4057qib7 11838 2 size size NN cord-005453-4057qib7 11838 3 range range NN cord-005453-4057qib7 11838 4 of of IN cord-005453-4057qib7 11838 5 the the DT cord-005453-4057qib7 11838 6 analysed analyse VBN cord-005453-4057qib7 11838 7 fragments fragment NNS cord-005453-4057qib7 11838 8 was be VBD cord-005453-4057qib7 11838 9 between between IN cord-005453-4057qib7 11838 10 80 80 CD cord-005453-4057qib7 11838 11 and and CC cord-005453-4057qib7 11838 12 200 200 CD cord-005453-4057qib7 11838 13 bp bp NNS cord-005453-4057qib7 11838 14 . . . cord-005453-4057qib7 11839 1 In in IN cord-005453-4057qib7 11839 2 41 41 CD cord-005453-4057qib7 11839 3 out out IN cord-005453-4057qib7 11839 4 of of IN cord-005453-4057qib7 11839 5 110 110 CD cord-005453-4057qib7 11839 6 patients patient NNS cord-005453-4057qib7 11839 7 a a DT cord-005453-4057qib7 11839 8 mixture mixture NN cord-005453-4057qib7 11839 9 of of IN cord-005453-4057qib7 11839 10 donor donor NN cord-005453-4057qib7 11839 11 and and CC cord-005453-4057qib7 11839 12 recipient recipient NN cord-005453-4057qib7 11839 13 cfDNA cfDNA . cord-005453-4057qib7 11840 1 ( ( -LRB- cord-005453-4057qib7 11840 2 MC MC NNP cord-005453-4057qib7 11840 3 ) ) -RRB- cord-005453-4057qib7 11840 4 was be VBD cord-005453-4057qib7 11840 5 detected detect VBN cord-005453-4057qib7 11840 6 . . . cord-005453-4057qib7 11841 1 With with IN cord-005453-4057qib7 11841 2 the the DT cord-005453-4057qib7 11841 3 exception exception NN cord-005453-4057qib7 11841 4 of of IN cord-005453-4057qib7 11841 5 three three CD cord-005453-4057qib7 11841 6 patients patient NNS cord-005453-4057qib7 11841 7 relapsing relapse VBG cord-005453-4057qib7 11841 8 after after IN cord-005453-4057qib7 11841 9 transplant transplant NN cord-005453-4057qib7 11841 10 in in IN cord-005453-4057qib7 11841 11 which which WDT cord-005453-4057qib7 11841 12 MC MC NNP cord-005453-4057qib7 11841 13 was be VBD cord-005453-4057qib7 11841 14 detected detect VBN cord-005453-4057qib7 11841 15 both both CC cord-005453-4057qib7 11841 16 in in IN cord-005453-4057qib7 11841 17 peripheral peripheral JJ cord-005453-4057qib7 11841 18 blood blood NN cord-005453-4057qib7 11841 19 and and CC cord-005453-4057qib7 11841 20 plasma plasma NN cord-005453-4057qib7 11841 21 in in IN cord-005453-4057qib7 11841 22 the the DT cord-005453-4057qib7 11841 23 rest rest NN cord-005453-4057qib7 11841 24 of of IN cord-005453-4057qib7 11841 25 the the DT cord-005453-4057qib7 11841 26 patients patient NNS cord-005453-4057qib7 11841 27 ( ( -LRB- cord-005453-4057qib7 11841 28 n=38 n=38 RB cord-005453-4057qib7 11841 29 ) ) -RRB- cord-005453-4057qib7 11842 1 MC MC NNP cord-005453-4057qib7 11842 2 was be VBD cord-005453-4057qib7 11842 3 detected detect VBN cord-005453-4057qib7 11842 4 only only RB cord-005453-4057qib7 11842 5 in in IN cord-005453-4057qib7 11842 6 plasma plasma NN cord-005453-4057qib7 11842 7 . . . cord-005453-4057qib7 11843 1 The the DT cord-005453-4057qib7 11843 2 mean mean JJ cord-005453-4057qib7 11843 3 percentage percentage NN cord-005453-4057qib7 11843 4 of of IN cord-005453-4057qib7 11843 5 recipient recipient NN cord-005453-4057qib7 11843 6 cfDNA cfdna RB cord-005453-4057qib7 11843 7 in in IN cord-005453-4057qib7 11843 8 the the DT cord-005453-4057qib7 11843 9 plasma plasma NN cord-005453-4057qib7 11843 10 samples sample NNS cord-005453-4057qib7 11843 11 was be VBD cord-005453-4057qib7 11843 12 18 18 CD cord-005453-4057qib7 11843 13 % % NN cord-005453-4057qib7 11843 14 ( ( -LRB- cord-005453-4057qib7 11843 15 range range NN cord-005453-4057qib7 11843 16 : : : cord-005453-4057qib7 11843 17 1 1 CD cord-005453-4057qib7 11843 18 - - SYM cord-005453-4057qib7 11843 19 81 81 CD cord-005453-4057qib7 11843 20 % % NN cord-005453-4057qib7 11843 21 ) ) -RRB- cord-005453-4057qib7 11843 22 . . . cord-005453-4057qib7 11844 1 All all PDT cord-005453-4057qib7 11844 2 the the DT cord-005453-4057qib7 11844 3 patients patient NNS cord-005453-4057qib7 11844 4 with with IN cord-005453-4057qib7 11844 5 acute acute JJ cord-005453-4057qib7 11844 6 GvHD GvHD NNP cord-005453-4057qib7 11844 7 ( ( -LRB- cord-005453-4057qib7 11844 8 aGvHD agvhd NN cord-005453-4057qib7 11844 9 ) ) -RRB- cord-005453-4057qib7 11844 10 ( ( -LRB- cord-005453-4057qib7 11844 11 grade grade NN cord-005453-4057qib7 11844 12 : : : cord-005453-4057qib7 11844 13 I I NNP cord-005453-4057qib7 11844 14 - - HYPH cord-005453-4057qib7 11844 15 IV IV NNP cord-005453-4057qib7 11844 16 ) ) -RRB- cord-005453-4057qib7 11844 17 ( ( -LRB- cord-005453-4057qib7 11844 18 n=15 n=15 NNP cord-005453-4057qib7 11844 19 ) ) -RRB- cord-005453-4057qib7 11844 20 showed show VBD cord-005453-4057qib7 11844 21 MC MC NNP cord-005453-4057qib7 11844 22 in in IN cord-005453-4057qib7 11844 23 plasma plasma NN cord-005453-4057qib7 11844 24 at at IN cord-005453-4057qib7 11844 25 least least JJS cord-005453-4057qib7 11844 26 in in IN cord-005453-4057qib7 11844 27 one one CD cord-005453-4057qib7 11844 28 of of IN cord-005453-4057qib7 11844 29 the the DT cord-005453-4057qib7 11844 30 time time NN cord-005453-4057qib7 11844 31 - - HYPH cord-005453-4057qib7 11844 32 point point NN cord-005453-4057qib7 11844 33 tested test VBN cord-005453-4057qib7 11844 34 . . . cord-005453-4057qib7 11845 1 No no DT cord-005453-4057qib7 11845 2 significant significant JJ cord-005453-4057qib7 11845 3 difference difference NN cord-005453-4057qib7 11845 4 was be VBD cord-005453-4057qib7 11845 5 found find VBN cord-005453-4057qib7 11845 6 in in IN cord-005453-4057qib7 11845 7 the the DT cord-005453-4057qib7 11845 8 mean mean JJ cord-005453-4057qib7 11845 9 recipient recipient NN cord-005453-4057qib7 11845 10 cfDNA cfdna JJ cord-005453-4057qib7 11845 11 percentage percentage NN cord-005453-4057qib7 11845 12 in in IN cord-005453-4057qib7 11845 13 patients patient NNS cord-005453-4057qib7 11845 14 with with IN cord-005453-4057qib7 11845 15 aGvHD aGvHD . cord-005453-4057qib7 11845 16 grade grade NN cord-005453-4057qib7 11845 17 I I NNP cord-005453-4057qib7 11845 18 - - HYPH cord-005453-4057qib7 11845 19 II II NNP cord-005453-4057qib7 11845 20 when when WRB cord-005453-4057qib7 11845 21 compared compare VBN cord-005453-4057qib7 11845 22 with with IN cord-005453-4057qib7 11845 23 grade grade NN cord-005453-4057qib7 11845 24 III III NNP cord-005453-4057qib7 11845 25 - - HYPH cord-005453-4057qib7 11845 26 IV IV NNP cord-005453-4057qib7 11845 27 . . . cord-005453-4057qib7 11846 1 Meanwhile meanwhile RB cord-005453-4057qib7 11846 2 in in IN cord-005453-4057qib7 11846 3 the the DT cord-005453-4057qib7 11846 4 group group NN cord-005453-4057qib7 11846 5 of of IN cord-005453-4057qib7 11846 6 patients patient NNS cord-005453-4057qib7 11846 7 with with IN cord-005453-4057qib7 11846 8 chronic chronic JJ cord-005453-4057qib7 11846 9 GvHD GvHD NNP cord-005453-4057qib7 11846 10 ( ( -LRB- cord-005453-4057qib7 11847 1 n=42 n=42 NNP cord-005453-4057qib7 11847 2 ) ) -RRB- cord-005453-4057qib7 11847 3 MC MC NNP cord-005453-4057qib7 11847 4 in in IN cord-005453-4057qib7 11847 5 plasma plasma NN cord-005453-4057qib7 11847 6 was be VBD cord-005453-4057qib7 11847 7 detected detect VBN cord-005453-4057qib7 11847 8 in in IN cord-005453-4057qib7 11847 9 13 13 CD cord-005453-4057qib7 11847 10 patients patient NNS cord-005453-4057qib7 11847 11 . . . cord-005453-4057qib7 11848 1 In in IN cord-005453-4057qib7 11848 2 those those DT cord-005453-4057qib7 11848 3 patients patient NNS cord-005453-4057qib7 11848 4 with with IN cord-005453-4057qib7 11848 5 clinical clinical JJ cord-005453-4057qib7 11848 6 improvement improvement NN cord-005453-4057qib7 11848 7 of of IN cord-005453-4057qib7 11848 8 aGvHD agvhd NN cord-005453-4057qib7 11848 9 ( ( -LRB- cord-005453-4057qib7 11848 10 n=6 n=6 NNP cord-005453-4057qib7 11848 11 ) ) -RRB- cord-005453-4057qib7 11848 12 a a DT cord-005453-4057qib7 11848 13 decrease decrease NN cord-005453-4057qib7 11848 14 in in IN cord-005453-4057qib7 11848 15 the the DT cord-005453-4057qib7 11848 16 percentage percentage NN cord-005453-4057qib7 11848 17 of of IN cord-005453-4057qib7 11848 18 recipient recipient NN cord-005453-4057qib7 11848 19 cfDNA cfDNA NNPS cord-005453-4057qib7 11848 20 was be VBD cord-005453-4057qib7 11848 21 observed observe VBN cord-005453-4057qib7 11848 22 during during IN cord-005453-4057qib7 11848 23 treatment treatment NN cord-005453-4057qib7 11848 24 . . . cord-005453-4057qib7 11849 1 In in IN cord-005453-4057qib7 11849 2 patients patient NNS cord-005453-4057qib7 11849 3 without without IN cord-005453-4057qib7 11849 4 improvement improvement NN cord-005453-4057qib7 11849 5 or or CC cord-005453-4057qib7 11849 6 even even RB cord-005453-4057qib7 11849 7 aGvHD agvhd NN cord-005453-4057qib7 11849 8 worsening worsen VBG cord-005453-4057qib7 11849 9 ( ( -LRB- cord-005453-4057qib7 11849 10 n=5 n=5 JJ cord-005453-4057qib7 11849 11 ) ) -RRB- cord-005453-4057qib7 11849 12 stable stable JJ cord-005453-4057qib7 11849 13 or or CC cord-005453-4057qib7 11849 14 increasing increase VBG cord-005453-4057qib7 11849 15 recipient recipient NN cord-005453-4057qib7 11849 16 cfDNA cfdna JJ cord-005453-4057qib7 11849 17 percentage percentage NN cord-005453-4057qib7 11849 18 was be VBD cord-005453-4057qib7 11849 19 detected detect VBN cord-005453-4057qib7 11849 20 . . . cord-005453-4057qib7 11850 1 Since since IN cord-005453-4057qib7 11850 2 recipient recipient NN cord-005453-4057qib7 11850 3 cfDNA cfdna EX cord-005453-4057qib7 11850 4 can can MD cord-005453-4057qib7 11850 5 be be VB cord-005453-4057qib7 11850 6 detected detect VBN cord-005453-4057qib7 11850 7 in in IN cord-005453-4057qib7 11850 8 patients patient NNS cord-005453-4057qib7 11850 9 without without IN cord-005453-4057qib7 11850 10 transplant transplant NN cord-005453-4057qib7 11850 11 - - HYPH cord-005453-4057qib7 11850 12 related relate VBN cord-005453-4057qib7 11850 13 complications complication NNS cord-005453-4057qib7 11850 14 we -PRON- PRP cord-005453-4057qib7 11850 15 analysed analyse VBD cord-005453-4057qib7 11850 16 the the DT cord-005453-4057qib7 11850 17 miRNA miRNA NNP cord-005453-4057qib7 11850 18 200c 200c CD cord-005453-4057qib7 11850 19 expression expression NN cord-005453-4057qib7 11850 20 in in IN cord-005453-4057qib7 11850 21 all all DT cord-005453-4057qib7 11850 22 patients patient NNS cord-005453-4057qib7 11850 23 with with IN cord-005453-4057qib7 11850 24 recipient recipient NN cord-005453-4057qib7 11850 25 cfDNA cfdna RB cord-005453-4057qib7 11850 26 . . . cord-005453-4057qib7 11851 1 A a DT cord-005453-4057qib7 11851 2 significant significant JJ cord-005453-4057qib7 11851 3 difference difference NN cord-005453-4057qib7 11851 4 was be VBD cord-005453-4057qib7 11851 5 found find VBN cord-005453-4057qib7 11851 6 in in IN cord-005453-4057qib7 11851 7 the the DT cord-005453-4057qib7 11851 8 miRNA miRNA NNP cord-005453-4057qib7 11851 9 200c 200c CD cord-005453-4057qib7 11851 10 expression expression NN cord-005453-4057qib7 11851 11 in in IN cord-005453-4057qib7 11851 12 patients patient NNS cord-005453-4057qib7 11851 13 with with IN cord-005453-4057qib7 11851 14 aGvHD agvhd NN cord-005453-4057qib7 11851 15 ( ( -LRB- cord-005453-4057qib7 11851 16 mean mean VB cord-005453-4057qib7 11851 17 miRNA miRNA NNP cord-005453-4057qib7 11851 18 200c 200c NNP cord-005453-4057qib7 11851 19 : : : cord-005453-4057qib7 11852 1 9.7 9.7 CD cord-005453-4057qib7 11852 2 miRNA miRNA NNP cord-005453-4057qib7 11852 3 200c 200c NNP cord-005453-4057qib7 11852 4 copies/10 copies/10 NNP cord-005453-4057qib7 11852 5 4 4 CD cord-005453-4057qib7 11852 6 U6 U6 NNP cord-005453-4057qib7 11852 7 copies copy NNS cord-005453-4057qib7 11852 8 ) ) -RRB- cord-005453-4057qib7 11852 9 when when WRB cord-005453-4057qib7 11852 10 compared compare VBN cord-005453-4057qib7 11852 11 with with IN cord-005453-4057qib7 11852 12 patients patient NNS cord-005453-4057qib7 11852 13 without without IN cord-005453-4057qib7 11852 14 GvHD GvHD NNP cord-005453-4057qib7 11852 15 ( ( -LRB- cord-005453-4057qib7 11852 16 mean mean VB cord-005453-4057qib7 11852 17 miRNA miRNA NNP cord-005453-4057qib7 11852 18 200c 200c NNP cord-005453-4057qib7 11852 19 : : : cord-005453-4057qib7 11853 1 35.4 35.4 CD cord-005453-4057qib7 11853 2 miRNA miRNA NNP cord-005453-4057qib7 11853 3 copies/10 copies/10 NNP cord-005453-4057qib7 11853 4 4 4 CD cord-005453-4057qib7 11853 5 U6 U6 NNP cord-005453-4057qib7 11853 6 copies copy NNS cord-005453-4057qib7 11853 7 ) ) -RRB- cord-005453-4057qib7 11853 8 . . . cord-005453-4057qib7 11854 1 In in IN cord-005453-4057qib7 11854 2 those those DT cord-005453-4057qib7 11854 3 patients patient NNS cord-005453-4057qib7 11854 4 with with IN cord-005453-4057qib7 11854 5 extramedullary extramedullary JJ cord-005453-4057qib7 11854 6 AML AML NNP cord-005453-4057qib7 11854 7 relapse relapse NN cord-005453-4057qib7 11854 8 ( ( -LRB- cord-005453-4057qib7 11854 9 n=3 n=3 NN cord-005453-4057qib7 11854 10 ) ) -RRB- cord-005453-4057qib7 11854 11 frequent frequent JJ cord-005453-4057qib7 11854 12 mutations mutation NNS cord-005453-4057qib7 11854 13 ( ( -LRB- cord-005453-4057qib7 11854 14 FLT3-ITD flt3-itd VB cord-005453-4057qib7 11854 15 , , , cord-005453-4057qib7 11854 16 NPM1 NPM1 NNP cord-005453-4057qib7 11854 17 ) ) -RRB- cord-005453-4057qib7 11855 1 were be VBD cord-005453-4057qib7 11855 2 only only RB cord-005453-4057qib7 11855 3 detected detect VBN cord-005453-4057qib7 11855 4 in in IN cord-005453-4057qib7 11855 5 the the DT cord-005453-4057qib7 11855 6 cfDNA cfdna JJ cord-005453-4057qib7 11855 7 fraction fraction NN cord-005453-4057qib7 11855 8 . . . cord-005453-4057qib7 11856 1 Conclusions conclusion NNS cord-005453-4057qib7 11856 2 : : : cord-005453-4057qib7 11857 1 Longitudinal longitudinal JJ cord-005453-4057qib7 11857 2 analysis analysis NN cord-005453-4057qib7 11857 3 of of IN cord-005453-4057qib7 11857 4 cfDNA cfDNA NNP cord-005453-4057qib7 11857 5 represents represent VBZ cord-005453-4057qib7 11857 6 a a DT cord-005453-4057qib7 11857 7 useful useful JJ cord-005453-4057qib7 11857 8 complementary complementary JJ cord-005453-4057qib7 11857 9 tool tool NN cord-005453-4057qib7 11857 10 in in IN cord-005453-4057qib7 11857 11 particular particular JJ cord-005453-4057qib7 11857 12 for for IN cord-005453-4057qib7 11857 13 those those DT cord-005453-4057qib7 11857 14 patients patient NNS cord-005453-4057qib7 11857 15 with with IN cord-005453-4057qib7 11857 16 clinical clinical JJ cord-005453-4057qib7 11857 17 complications complication NNS cord-005453-4057qib7 11857 18 after after IN cord-005453-4057qib7 11857 19 HSCT HSCT NNP cord-005453-4057qib7 11857 20 . . . cord-005453-4057qib7 11858 1 Disclosure disclosure NN cord-005453-4057qib7 11858 2 : : : cord-005453-4057qib7 11858 3 Nothing nothing NN cord-005453-4057qib7 11858 4 to to TO cord-005453-4057qib7 11858 5 declare declare VB cord-005453-4057qib7 11858 6 Comparison comparison NN cord-005453-4057qib7 11858 7 of of IN cord-005453-4057qib7 11858 8 the the DT cord-005453-4057qib7 11858 9 impact impact NN cord-005453-4057qib7 11858 10 of of IN cord-005453-4057qib7 11858 11 ATG ATG NNP cord-005453-4057qib7 11858 12 / / SYM cord-005453-4057qib7 11858 13 PT PT NNP cord-005453-4057qib7 11858 14 - - HYPH cord-005453-4057qib7 11858 15 CY CY NNP cord-005453-4057qib7 11858 16 - - HYPH cord-005453-4057qib7 11858 17 based base VBN cord-005453-4057qib7 11858 18 and and CC cord-005453-4057qib7 11858 19 TCR TCR NNP cord-005453-4057qib7 11858 20 αβ αβ NN cord-005453-4057qib7 11858 21 - - HYPH cord-005453-4057qib7 11858 22 depletion depletion NN cord-005453-4057qib7 11858 23 as as IN cord-005453-4057qib7 11858 24 GVHD GVHD NNP cord-005453-4057qib7 11858 25 prophylaxis prophylaxis NN cord-005453-4057qib7 11858 26 regimens regimen NNS cord-005453-4057qib7 11858 27 on on IN cord-005453-4057qib7 11858 28 the the DT cord-005453-4057qib7 11858 29 recovery recovery NN cord-005453-4057qib7 11858 30 of of IN cord-005453-4057qib7 11858 31 memory memory NN cord-005453-4057qib7 11858 32 T t NN cord-005453-4057qib7 11858 33 - - HYPH cord-005453-4057qib7 11858 34 cell cell NN cord-005453-4057qib7 11858 35 compartment compartment NN cord-005453-4057qib7 11858 36 Background background NN cord-005453-4057qib7 11858 37 : : : cord-005453-4057qib7 11859 1 Over over IN cord-005453-4057qib7 11859 2 recent recent JJ cord-005453-4057qib7 11859 3 years year NNS cord-005453-4057qib7 11859 4 haploidentical haploidentical JJ cord-005453-4057qib7 11859 5 and and CC cord-005453-4057qib7 11859 6 HLAmismatched hlamismatched JJ cord-005453-4057qib7 11859 7 donors donor NNS cord-005453-4057qib7 11859 8 have have VBP cord-005453-4057qib7 11859 9 been be VBN cord-005453-4057qib7 11859 10 increasingly increasingly RB cord-005453-4057qib7 11859 11 adopted adopt VBN cord-005453-4057qib7 11859 12 as as IN cord-005453-4057qib7 11859 13 a a DT cord-005453-4057qib7 11859 14 valid valid JJ cord-005453-4057qib7 11859 15 donor donor NN cord-005453-4057qib7 11859 16 source source NN cord-005453-4057qib7 11859 17 . . . cord-005453-4057qib7 11860 1 Modern modern JJ cord-005453-4057qib7 11860 2 graft graft NN cord-005453-4057qib7 11860 3 - - HYPH cord-005453-4057qib7 11860 4 versus versus IN cord-005453-4057qib7 11860 5 - - HYPH cord-005453-4057qib7 11860 6 host host NN cord-005453-4057qib7 11860 7 disease disease NN cord-005453-4057qib7 11860 8 ( ( -LRB- cord-005453-4057qib7 11861 1 GVHD GVHD NNP cord-005453-4057qib7 11861 2 ) ) -RRB- cord-005453-4057qib7 11861 3 prophylaxis prophylaxis NN cord-005453-4057qib7 11861 4 regimens regimen NNS cord-005453-4057qib7 11861 5 such such JJ cord-005453-4057qib7 11861 6 as as IN cord-005453-4057qib7 11861 7 drug drug NN cord-005453-4057qib7 11861 8 - - HYPH cord-005453-4057qib7 11861 9 based base VBN cord-005453-4057qib7 11861 10 ( ( -LRB- cord-005453-4057qib7 11861 11 antithymocyte antithymocyte NNP cord-005453-4057qib7 11861 12 globulin globulin NN cord-005453-4057qib7 11861 13 ( ( -LRB- cord-005453-4057qib7 11861 14 ATG ATG NNP cord-005453-4057qib7 11861 15 ) ) -RRB- cord-005453-4057qib7 11861 16 , , , cord-005453-4057qib7 11861 17 post post JJ cord-005453-4057qib7 11861 18 - - JJ cord-005453-4057qib7 11861 19 transplant transplant NN cord-005453-4057qib7 11861 20 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 11861 21 ( ( -LRB- cord-005453-4057qib7 11861 22 PT PT NNP cord-005453-4057qib7 11861 23 - - HYPH cord-005453-4057qib7 11861 24 Cy Cy NNP cord-005453-4057qib7 11861 25 ) ) -RRB- cord-005453-4057qib7 11861 26 ) ) -RRB- cord-005453-4057qib7 11861 27 or or CC cord-005453-4057qib7 11861 28 graft graft NN cord-005453-4057qib7 11861 29 - - HYPH cord-005453-4057qib7 11861 30 manipulated manipulate VBN cord-005453-4057qib7 11861 31 ( ( -LRB- cord-005453-4057qib7 11861 32 TCR TCR NNP cord-005453-4057qib7 11861 33 αβ αβ NN cord-005453-4057qib7 11861 34 - - HYPH cord-005453-4057qib7 11861 35 depletion depletion NN cord-005453-4057qib7 11861 36 ) ) -RRB- cord-005453-4057qib7 11861 37 demonstrate demonstrate VB cord-005453-4057qib7 11861 38 effective effective JJ cord-005453-4057qib7 11861 39 prevention prevention NN cord-005453-4057qib7 11861 40 of of IN cord-005453-4057qib7 11861 41 GVHD GVHD NNP cord-005453-4057qib7 11861 42 . . . cord-005453-4057qib7 11862 1 Here here RB cord-005453-4057qib7 11862 2 we -PRON- PRP cord-005453-4057qib7 11862 3 report report VBP cord-005453-4057qib7 11862 4 our -PRON- PRP$ cord-005453-4057qib7 11862 5 data datum NNS cord-005453-4057qib7 11862 6 about about IN cord-005453-4057qib7 11862 7 an an DT cord-005453-4057qib7 11862 8 influence influence NN cord-005453-4057qib7 11862 9 of of IN cord-005453-4057qib7 11862 10 different different JJ cord-005453-4057qib7 11862 11 GVHD GVHD NNP cord-005453-4057qib7 11862 12 prophylaxis prophylaxis NN cord-005453-4057qib7 11862 13 regimens regimen NNS cord-005453-4057qib7 11862 14 after after IN cord-005453-4057qib7 11862 15 allo allo NN cord-005453-4057qib7 11862 16 - - HYPH cord-005453-4057qib7 11862 17 HSCT HSCT NNP cord-005453-4057qib7 11862 18 with with IN cord-005453-4057qib7 11862 19 PBSC PBSC NNP cord-005453-4057qib7 11862 20 as as IN cord-005453-4057qib7 11862 21 a a DT cord-005453-4057qib7 11862 22 graft graft NN cord-005453-4057qib7 11862 23 source source NN cord-005453-4057qib7 11862 24 on on IN cord-005453-4057qib7 11862 25 CD8 CD8 NNP cord-005453-4057qib7 11862 26 + + CC cord-005453-4057qib7 11862 27 memory memory NN cord-005453-4057qib7 11862 28 T T NNP cord-005453-4057qib7 11862 29 - - HYPH cord-005453-4057qib7 11862 30 cells cell NNS cord-005453-4057qib7 11862 31 recovery recovery NN cord-005453-4057qib7 11862 32 . . . cord-005453-4057qib7 11863 1 Methods method NNS cord-005453-4057qib7 11863 2 : : : cord-005453-4057qib7 11863 3 Our -PRON- PRP$ cord-005453-4057qib7 11863 4 study study NN cord-005453-4057qib7 11863 5 comprised comprise VBD cord-005453-4057qib7 11863 6 32 32 CD cord-005453-4057qib7 11863 7 leukemia leukemia NN cord-005453-4057qib7 11863 8 patients patient NNS cord-005453-4057qib7 11863 9 who who WP cord-005453-4057qib7 11863 10 underwent undergo VBD cord-005453-4057qib7 11863 11 allo allo NN cord-005453-4057qib7 11863 12 - - HYPH cord-005453-4057qib7 11863 13 HSCT HSCT NNP cord-005453-4057qib7 11863 14 with with IN cord-005453-4057qib7 11863 15 PBSC PBSC NNP cord-005453-4057qib7 11863 16 as as IN cord-005453-4057qib7 11863 17 a a DT cord-005453-4057qib7 11863 18 graft graft NN cord-005453-4057qib7 11863 19 source source NN cord-005453-4057qib7 11863 20 in in IN cord-005453-4057qib7 11863 21 National National NNP cord-005453-4057qib7 11863 22 Research Research NNP cord-005453-4057qib7 11863 23 Center Center NNP cord-005453-4057qib7 11863 24 for for IN cord-005453-4057qib7 11863 25 Hematology Hematology NNP cord-005453-4057qib7 11863 26 , , , cord-005453-4057qib7 11863 27 Moscow Moscow NNP cord-005453-4057qib7 11863 28 , , , cord-005453-4057qib7 11863 29 Russia Russia NNP cord-005453-4057qib7 11863 30 . . . cord-005453-4057qib7 11864 1 Detailed detailed JJ cord-005453-4057qib7 11864 2 patients patient NNS cord-005453-4057qib7 11864 3 characteristics characteristic NNS cord-005453-4057qib7 11864 4 are be VBP cord-005453-4057qib7 11864 5 presented present VBN cord-005453-4057qib7 11864 6 in in IN cord-005453-4057qib7 11864 7 Table Table NNP cord-005453-4057qib7 11864 8 1 1 CD cord-005453-4057qib7 11864 9 . . . cord-005453-4057qib7 11865 1 Peripheral peripheral JJ cord-005453-4057qib7 11865 2 blood blood NN cord-005453-4057qib7 11865 3 samples sample NNS cord-005453-4057qib7 11865 4 were be VBD cord-005453-4057qib7 11865 5 collected collect VBN cord-005453-4057qib7 11865 6 on on IN cord-005453-4057qib7 11865 7 day day NN cord-005453-4057qib7 11865 8 +30 +30 CD cord-005453-4057qib7 11865 9 , , , cord-005453-4057qib7 11865 10 +60 +60 NNP cord-005453-4057qib7 11865 11 and and CC cord-005453-4057qib7 11865 12 +90 +90 NN cord-005453-4057qib7 11865 13 after after IN cord-005453-4057qib7 11865 14 allo allo NN cord-005453-4057qib7 11865 15 - - HYPH cord-005453-4057qib7 11865 16 HSCT HSCT NNP cord-005453-4057qib7 11865 17 . . . cord-005453-4057qib7 11866 1 Flow flow NN cord-005453-4057qib7 11866 2 cytometry cytometry NN cord-005453-4057qib7 11866 3 analysis analysis NN cord-005453-4057qib7 11866 4 was be VBD cord-005453-4057qib7 11866 5 performed perform VBN cord-005453-4057qib7 11866 6 on on IN cord-005453-4057qib7 11866 7 BD BD NNP cord-005453-4057qib7 11866 8 FACS FACS NNP cord-005453-4057qib7 11866 9 Canto Canto NNP cord-005453-4057qib7 11866 10 II II NNP cord-005453-4057qib7 11867 1 ( ( -LRB- cord-005453-4057qib7 11867 2 Becton Becton NNP cord-005453-4057qib7 11867 3 Dickinson Dickinson NNP cord-005453-4057qib7 11867 4 , , , cord-005453-4057qib7 11867 5 USA USA NNP cord-005453-4057qib7 11867 6 ) ) -RRB- cord-005453-4057qib7 11867 7 to to TO cord-005453-4057qib7 11867 8 define define VB cord-005453-4057qib7 11867 9 T t NN cord-005453-4057qib7 11867 10 - - HYPH cord-005453-4057qib7 11867 11 memory memory NN cord-005453-4057qib7 11867 12 subsets subset NNS cord-005453-4057qib7 11867 13 : : : cord-005453-4057qib7 11867 14 T t NN cord-005453-4057qib7 11867 15 - - HYPH cord-005453-4057qib7 11867 16 naive naive JJ cord-005453-4057qib7 11867 17 and and CC cord-005453-4057qib7 11867 18 T t NN cord-005453-4057qib7 11867 19 - - HYPH cord-005453-4057qib7 11867 20 stem stem NN cord-005453-4057qib7 11867 21 cell cell NN cord-005453-4057qib7 11867 22 memory memory NN cord-005453-4057qib7 11868 1 ( ( -LRB- cord-005453-4057qib7 11868 2 Tnv+Tscm Tnv+Tscm NNP cord-005453-4057qib7 11868 3 ) ) -RRB- cord-005453-4057qib7 11869 1 -CD8+CD45R0-CCR7 -CD8+CD45R0-CCR7 . cord-005453-4057qib7 11870 1 + + CC cord-005453-4057qib7 11871 1 CD28 CD28 NNP cord-005453-4057qib7 11872 1 + + CC cord-005453-4057qib7 11872 2 ; ; : cord-005453-4057qib7 11872 3 T t JJ cord-005453-4057qib7 11872 4 - - HYPH cord-005453-4057qib7 11872 5 central central JJ cord-005453-4057qib7 11872 6 memory memory NN cord-005453-4057qib7 11872 7 ( ( -LRB- cord-005453-4057qib7 11872 8 Tcm Tcm NNP cord-005453-4057qib7 11872 9 ) ) -RRB- cord-005453-4057qib7 11872 10 -CD8+CD45R0 -CD8+CD45R0 : cord-005453-4057qib7 11872 11 + + CC cord-005453-4057qib7 11872 12 CCR7+CD28 CCR7+CD28 NNP cord-005453-4057qib7 11872 13 + + CC cord-005453-4057qib7 11872 14 ; ; : cord-005453-4057qib7 11872 15 T t JJ cord-005453-4057qib7 11872 16 - - HYPH cord-005453-4057qib7 11872 17 transitional transitional JJ cord-005453-4057qib7 11872 18 memory memory NN cord-005453-4057qib7 11872 19 ( ( -LRB- cord-005453-4057qib7 11872 20 Ttm Ttm NNP cord-005453-4057qib7 11872 21 ) ) -RRB- cord-005453-4057qib7 11872 22 -CD8 -CD8 . cord-005453-4057qib7 11873 1 + + CC cord-005453-4057qib7 11874 1 CD45R0+CCR7-CD28 CD45R0+CCR7-CD28 NNP cord-005453-4057qib7 11875 1 + + CC cord-005453-4057qib7 11875 2 ; ; : cord-005453-4057qib7 11875 3 T t NN cord-005453-4057qib7 11875 4 - - HYPH cord-005453-4057qib7 11875 5 effector effector NN cord-005453-4057qib7 11875 6 memory memory NN cord-005453-4057qib7 11875 7 ( ( -LRB- cord-005453-4057qib7 11875 8 Tem Tem NNP cord-005453-4057qib7 11875 9 ) ) -RRB- cord-005453-4057qib7 11875 10 -CD8+CD45R0+CCR7-CD28- -cd8+cd45r0+ccr7-cd28- NN cord-005453-4057qib7 11875 11 ; ; : cord-005453-4057qib7 11875 12 T t NN cord-005453-4057qib7 11875 13 - - HYPH cord-005453-4057qib7 11875 14 terminal terminal NN cord-005453-4057qib7 11875 15 effector effector NN cord-005453-4057qib7 11875 16 ( ( -LRB- cord-005453-4057qib7 11875 17 Tte Tte NNP cord-005453-4057qib7 11875 18 ) ) -RRB- cord-005453-4057qib7 11875 19 -CD8+CD45R0-CCR7-CD28- -cd8+cd45r0-ccr7-cd28- ADD cord-005453-4057qib7 11875 20 . . . cord-005453-4057qib7 11876 1 Sysmex Sysmex NNP cord-005453-4057qib7 11876 2 XE-2100 XE-2100 NNS cord-005453-4057qib7 11876 3 was be VBD cord-005453-4057qib7 11876 4 used use VBN cord-005453-4057qib7 11876 5 to to TO cord-005453-4057qib7 11876 6 calculate calculate VB cord-005453-4057qib7 11876 7 absolute absolute JJ cord-005453-4057qib7 11876 8 count count NN cord-005453-4057qib7 11876 9 of of IN cord-005453-4057qib7 11876 10 different different JJ cord-005453-4057qib7 11876 11 T t NN cord-005453-4057qib7 11876 12 - - HYPH cord-005453-4057qib7 11876 13 memory memory NN cord-005453-4057qib7 11876 14 cell cell NN cord-005453-4057qib7 11876 15 subsets subset NNS cord-005453-4057qib7 11876 16 . . . cord-005453-4057qib7 11877 1 Mann Mann NNP cord-005453-4057qib7 11877 2 - - HYPH cord-005453-4057qib7 11877 3 Whitney Whitney NNP cord-005453-4057qib7 11877 4 U U NNP cord-005453-4057qib7 11877 5 test test NN cord-005453-4057qib7 11877 6 was be VBD cord-005453-4057qib7 11877 7 used use VBN cord-005453-4057qib7 11877 8 for for IN cord-005453-4057qib7 11877 9 nonparametric nonparametric JJ cord-005453-4057qib7 11877 10 data datum NNS cord-005453-4057qib7 11877 11 analysis analysis NN cord-005453-4057qib7 11877 12 . . . cord-005453-4057qib7 11878 1 A a DT cord-005453-4057qib7 11878 2 p p NN cord-005453-4057qib7 11878 3 - - HYPH cord-005453-4057qib7 11878 4 value value NN cord-005453-4057qib7 11878 5 less less JJR cord-005453-4057qib7 11878 6 than than IN cord-005453-4057qib7 11878 7 0.05 0.05 CD cord-005453-4057qib7 11878 8 was be VBD cord-005453-4057qib7 11878 9 considered consider VBN cord-005453-4057qib7 11878 10 as as RB cord-005453-4057qib7 11878 11 significant significant JJ cord-005453-4057qib7 11878 12 . . . cord-005453-4057qib7 11879 1 Results result NNS cord-005453-4057qib7 11879 2 : : : cord-005453-4057qib7 11879 3 Results result NNS cord-005453-4057qib7 11879 4 of of IN cord-005453-4057qib7 11879 5 Mann Mann NNP cord-005453-4057qib7 11879 6 - - HYPH cord-005453-4057qib7 11879 7 Whitney Whitney NNP cord-005453-4057qib7 11879 8 U U NNP cord-005453-4057qib7 11879 9 test test NN cord-005453-4057qib7 11879 10 ( ( -LRB- cord-005453-4057qib7 11879 11 calculated calculate VBN cord-005453-4057qib7 11879 12 pvalues pvalues NNP cord-005453-4057qib7 11879 13 ) ) -RRB- cord-005453-4057qib7 11880 1 to to TO cord-005453-4057qib7 11880 2 compare compare VB cord-005453-4057qib7 11880 3 absolute absolute JJ cord-005453-4057qib7 11880 4 number number NN cord-005453-4057qib7 11880 5 of of IN cord-005453-4057qib7 11880 6 T t NN cord-005453-4057qib7 11880 7 - - HYPH cord-005453-4057qib7 11880 8 memory memory NN cord-005453-4057qib7 11880 9 cell cell NN cord-005453-4057qib7 11880 10 subsets subset NNS cord-005453-4057qib7 11880 11 in in IN cord-005453-4057qib7 11880 12 terms term NNS cord-005453-4057qib7 11880 13 of of IN cord-005453-4057qib7 11880 14 different different JJ cord-005453-4057qib7 11880 15 GVHD GVHD NNP cord-005453-4057qib7 11880 16 prophylaxis prophylaxis NN cord-005453-4057qib7 11880 17 regimens regimen NNS cord-005453-4057qib7 11880 18 are be VBP cord-005453-4057qib7 11880 19 presented present VBN cord-005453-4057qib7 11880 20 in in IN cord-005453-4057qib7 11880 21 Figure figure NN cord-005453-4057qib7 11880 22 1 1 CD cord-005453-4057qib7 11880 23 . . . cord-005453-4057qib7 11881 1 During during IN cord-005453-4057qib7 11881 2 all all DT cord-005453-4057qib7 11881 3 follow follow VB cord-005453-4057qib7 11881 4 - - HYPH cord-005453-4057qib7 11881 5 up up NN cord-005453-4057qib7 11881 6 period period NN cord-005453-4057qib7 11881 7 the the DT cord-005453-4057qib7 11881 8 number number NN cord-005453-4057qib7 11881 9 of of IN cord-005453-4057qib7 11881 10 Tnv+scm Tnv+scm NNP cord-005453-4057qib7 11881 11 and and CC cord-005453-4057qib7 11881 12 Tcm Tcm NNP cord-005453-4057qib7 11881 13 remains remain VBZ cord-005453-4057qib7 11881 14 significantly significantly RB cord-005453-4057qib7 11881 15 reduced reduce VBN cord-005453-4057qib7 11881 16 after after IN cord-005453-4057qib7 11881 17 ATG+PT ATG+PT NNP cord-005453-4057qib7 11881 18 - - HYPH cord-005453-4057qib7 11881 19 Cy Cy NNP cord-005453-4057qib7 11881 20 or or CC cord-005453-4057qib7 11881 21 TCR TCR NNP cord-005453-4057qib7 11881 22 αβ αβ NN cord-005453-4057qib7 11881 23 - - HYPH cord-005453-4057qib7 11881 24 depletion depletion NN cord-005453-4057qib7 11881 25 compared compare VBN cord-005453-4057qib7 11881 26 to to IN cord-005453-4057qib7 11881 27 ATG ATG NNP cord-005453-4057qib7 11881 28 - - HYPH cord-005453-4057qib7 11881 29 based base VBN cord-005453-4057qib7 11881 30 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 11881 31 regimen regimen NN cord-005453-4057qib7 11881 32 . . . cord-005453-4057qib7 11882 1 On on IN cord-005453-4057qib7 11882 2 day day NN cord-005453-4057qib7 11882 3 +30 +30 CD cord-005453-4057qib7 11882 4 we -PRON- PRP cord-005453-4057qib7 11882 5 observe observe VBP cord-005453-4057qib7 11882 6 no no DT cord-005453-4057qib7 11882 7 difference difference NN cord-005453-4057qib7 11882 8 in in IN cord-005453-4057qib7 11882 9 the the DT cord-005453-4057qib7 11882 10 number number NN cord-005453-4057qib7 11882 11 of of IN cord-005453-4057qib7 11882 12 Tnv+scm Tnv+scm NNP cord-005453-4057qib7 11882 13 and and CC cord-005453-4057qib7 11882 14 Tcm Tcm NNP cord-005453-4057qib7 11882 15 cells cell NNS cord-005453-4057qib7 11882 16 after after IN cord-005453-4057qib7 11882 17 ATG+PT ATG+PT NNP cord-005453-4057qib7 11882 18 - - HYPH cord-005453-4057qib7 11882 19 Cy Cy NNP cord-005453-4057qib7 11882 20 or or CC cord-005453-4057qib7 11882 21 TCR TCR NNP cord-005453-4057qib7 11882 22 αβ αβ NN cord-005453-4057qib7 11882 23 - - HYPH cord-005453-4057qib7 11882 24 depletion depletion NN cord-005453-4057qib7 11882 25 . . . cord-005453-4057qib7 11883 1 Terminally terminally RB cord-005453-4057qib7 11883 2 differentiated differentiate VBN cord-005453-4057qib7 11883 3 CD8 CD8 NNP cord-005453-4057qib7 11883 4 + + CC cord-005453-4057qib7 11883 5 cells cell NNS cord-005453-4057qib7 11883 6 ( ( -LRB- cord-005453-4057qib7 11884 1 Ttm Ttm NNP cord-005453-4057qib7 11884 2 , , , cord-005453-4057qib7 11884 3 Tem Tem NNP cord-005453-4057qib7 11884 4 , , , cord-005453-4057qib7 11884 5 Tte Tte NNP cord-005453-4057qib7 11884 6 ) ) -RRB- cord-005453-4057qib7 11884 7 count count NN cord-005453-4057qib7 11884 8 is be VBZ cord-005453-4057qib7 11884 9 significantly significantly RB cord-005453-4057qib7 11884 10 lowered lower VBN cord-005453-4057qib7 11884 11 in in IN cord-005453-4057qib7 11884 12 TCR TCR NNP cord-005453-4057qib7 11884 13 αβ αβ NN cord-005453-4057qib7 11884 14 - - HYPH cord-005453-4057qib7 11884 15 depletion depletion NN cord-005453-4057qib7 11884 16 patients patient NNS cord-005453-4057qib7 11884 17 group group NN cord-005453-4057qib7 11884 18 in in IN cord-005453-4057qib7 11884 19 comparison comparison NN cord-005453-4057qib7 11884 20 to to IN cord-005453-4057qib7 11884 21 ATG+PT ATG+PT NNP cord-005453-4057qib7 11884 22 - - HYPH cord-005453-4057qib7 11884 23 Cy Cy NNP cord-005453-4057qib7 11884 24 . . . cord-005453-4057qib7 11885 1 Nevertheless nevertheless RB cord-005453-4057qib7 11885 2 recovery recovery NN cord-005453-4057qib7 11885 3 of of IN cord-005453-4057qib7 11885 4 Tnv+scm Tnv+scm NNP cord-005453-4057qib7 11885 5 and and CC cord-005453-4057qib7 11885 6 Tcm Tcm NNP cord-005453-4057qib7 11885 7 after after IN cord-005453-4057qib7 11885 8 PT PT NNP cord-005453-4057qib7 11885 9 - - HYPH cord-005453-4057qib7 11885 10 Cy Cy NNP cord-005453-4057qib7 11885 11 is be VBZ cord-005453-4057qib7 11885 12 faster fast JJR cord-005453-4057qib7 11885 13 than than IN cord-005453-4057qib7 11885 14 after after IN cord-005453-4057qib7 11885 15 TCR TCR NNP cord-005453-4057qib7 11885 16 αβ αβ NN cord-005453-4057qib7 11885 17 - - HYPH cord-005453-4057qib7 11885 18 depletion depletion NN cord-005453-4057qib7 11885 19 . . . cord-005453-4057qib7 11886 1 Conclusions conclusion NNS cord-005453-4057qib7 11886 2 : : : cord-005453-4057qib7 11887 1 According accord VBG cord-005453-4057qib7 11887 2 to to IN cord-005453-4057qib7 11887 3 our -PRON- PRP$ cord-005453-4057qib7 11887 4 data datum NNS cord-005453-4057qib7 11887 5 the the DT cord-005453-4057qib7 11887 6 mechanism mechanism NN cord-005453-4057qib7 11887 7 of of IN cord-005453-4057qib7 11887 8 PT PT NNP cord-005453-4057qib7 11887 9 - - HYPH cord-005453-4057qib7 11887 10 Cy Cy NNP cord-005453-4057qib7 11887 11 is be VBZ cord-005453-4057qib7 11887 12 seems seem VBZ cord-005453-4057qib7 11887 13 to to TO cord-005453-4057qib7 11887 14 be be VB cord-005453-4057qib7 11887 15 more more RBR cord-005453-4057qib7 11887 16 selective selective JJ cord-005453-4057qib7 11887 17 compared compare VBN cord-005453-4057qib7 11887 18 to to IN cord-005453-4057qib7 11887 19 TCR TCR NNP cord-005453-4057qib7 11887 20 αβ αβ NN cord-005453-4057qib7 11887 21 - - HYPH cord-005453-4057qib7 11887 22 depletion depletion NN cord-005453-4057qib7 11887 23 due due IN cord-005453-4057qib7 11887 24 to to IN cord-005453-4057qib7 11887 25 its -PRON- PRP$ cord-005453-4057qib7 11887 26 transient transient JJ cord-005453-4057qib7 11887 27 impact impact NN cord-005453-4057qib7 11887 28 just just RB cord-005453-4057qib7 11887 29 on on IN cord-005453-4057qib7 11887 30 Tnv+scm Tnv+scm NNP cord-005453-4057qib7 11887 31 and and CC cord-005453-4057qib7 11887 32 Tcm Tcm NNP cord-005453-4057qib7 11887 33 without without IN cord-005453-4057qib7 11887 34 affecting affect VBG cord-005453-4057qib7 11887 35 on on IN cord-005453-4057qib7 11887 36 the the DT cord-005453-4057qib7 11887 37 effector effector JJ cord-005453-4057qib7 11887 38 pool pool NN cord-005453-4057qib7 11887 39 . . . cord-005453-4057qib7 11888 1 Through through IN cord-005453-4057qib7 11888 2 this this DT cord-005453-4057qib7 11888 3 it -PRON- PRP cord-005453-4057qib7 11888 4 may may MD cord-005453-4057qib7 11888 5 lead lead VB cord-005453-4057qib7 11888 6 to to IN cord-005453-4057qib7 11888 7 delayed delay VBN cord-005453-4057qib7 11888 8 reconstitution reconstitution NN cord-005453-4057qib7 11888 9 of of IN cord-005453-4057qib7 11888 10 adaptive adaptive JJ cord-005453-4057qib7 11888 11 immunity immunity NN cord-005453-4057qib7 11888 12 after after IN cord-005453-4057qib7 11888 13 TCR TCR NNP cord-005453-4057qib7 11888 14 αβ αβ NN cord-005453-4057qib7 11888 15 - - HYPH cord-005453-4057qib7 11888 16 depletion depletion NN cord-005453-4057qib7 11888 17 compared compare VBN cord-005453-4057qib7 11888 18 to to IN cord-005453-4057qib7 11888 19 using use VBG cord-005453-4057qib7 11888 20 PT PT NNP cord-005453-4057qib7 11888 21 - - HYPH cord-005453-4057qib7 11888 22 Cy Cy NNP cord-005453-4057qib7 11888 23 . . . cord-005453-4057qib7 11889 1 Clinical clinical JJ cord-005453-4057qib7 11889 2 relevance relevance NN cord-005453-4057qib7 11889 3 of of IN cord-005453-4057qib7 11889 4 the the DT cord-005453-4057qib7 11889 5 quantitative quantitative JJ cord-005453-4057qib7 11889 6 characteristics characteristic NNS cord-005453-4057qib7 11889 7 of of IN cord-005453-4057qib7 11889 8 immune immune JJ cord-005453-4057qib7 11889 9 recovery recovery NN cord-005453-4057qib7 11889 10 in in IN cord-005453-4057qib7 11889 11 the the DT cord-005453-4057qib7 11889 12 context context NN cord-005453-4057qib7 11889 13 of of IN cord-005453-4057qib7 11889 14 different different JJ cord-005453-4057qib7 11889 15 approaches approach NNS cord-005453-4057qib7 11889 16 to to IN cord-005453-4057qib7 11889 17 GVHD GVHD NNP cord-005453-4057qib7 11889 18 prevention prevention NN cord-005453-4057qib7 11889 19 remains remain VBZ cord-005453-4057qib7 11889 20 to to TO cord-005453-4057qib7 11889 21 be be VB cord-005453-4057qib7 11889 22 established establish VBN cord-005453-4057qib7 11889 23 . . . cord-005453-4057qib7 11890 1 Background background NN cord-005453-4057qib7 11890 2 : : : cord-005453-4057qib7 11891 1 Immune immune JJ cord-005453-4057qib7 11891 2 effector effector NN cord-005453-4057qib7 11891 3 cells cell NNS cord-005453-4057qib7 11891 4 , , , cord-005453-4057qib7 11891 5 belonging belong VBG cord-005453-4057qib7 11891 6 to to IN cord-005453-4057qib7 11891 7 either either CC cord-005453-4057qib7 11891 8 innate innate JJ cord-005453-4057qib7 11891 9 or or CC cord-005453-4057qib7 11891 10 acquired acquire VBN cord-005453-4057qib7 11891 11 immunity immunity NN cord-005453-4057qib7 11891 12 , , , cord-005453-4057qib7 11891 13 play play VB cord-005453-4057qib7 11891 14 a a DT cord-005453-4057qib7 11891 15 key key JJ cord-005453-4057qib7 11891 16 role role NN cord-005453-4057qib7 11891 17 on on IN cord-005453-4057qib7 11891 18 preventing prevent VBG cord-005453-4057qib7 11891 19 disease disease NN cord-005453-4057qib7 11891 20 relapse relapse NN cord-005453-4057qib7 11891 21 after after IN cord-005453-4057qib7 11891 22 allogeneic allogeneic JJ cord-005453-4057qib7 11891 23 Haematopoietic Haematopoietic NNP cord-005453-4057qib7 11891 24 Stem Stem NNP cord-005453-4057qib7 11891 25 Cell Cell NNP cord-005453-4057qib7 11891 26 Transplantation transplantation NN cord-005453-4057qib7 11891 27 ( ( -LRB- cord-005453-4057qib7 11891 28 HSCT HSCT NNP cord-005453-4057qib7 11891 29 ) ) -RRB- cord-005453-4057qib7 11891 30 . . . cord-005453-4057qib7 11892 1 Most Most JJS cord-005453-4057qib7 11892 2 of of IN cord-005453-4057qib7 11892 3 known know VBN cord-005453-4057qib7 11892 4 immune immune JJ cord-005453-4057qib7 11892 5 effector effector NN cord-005453-4057qib7 11892 6 are be VBP cord-005453-4057qib7 11892 7 CD3 CD3 NNP cord-005453-4057qib7 11892 8 + + SYM cord-005453-4057qib7 11892 9 CD8 CD8 NNP cord-005453-4057qib7 11892 10 + + CC cord-005453-4057qib7 11892 11 T T NNP cord-005453-4057qib7 11892 12 - - HYPH cord-005453-4057qib7 11892 13 cells cell NNS cord-005453-4057qib7 11892 14 and and CC cord-005453-4057qib7 11892 15 CD3 CD3 NNP cord-005453-4057qib7 11892 16 -CD56 -cd56 NN cord-005453-4057qib7 11892 17 + + NNP cord-005453-4057qib7 11892 18 Natural Natural NNP cord-005453-4057qib7 11892 19 Killer Killer NNP cord-005453-4057qib7 11892 20 lymphocytes lymphocyte NNS cord-005453-4057qib7 11892 21 , , , cord-005453-4057qib7 11892 22 while while IN cord-005453-4057qib7 11892 23 CD3 CD3 NNP cord-005453-4057qib7 11892 24 + + SYM cord-005453-4057qib7 11892 25 CD4 CD4 NNP cord-005453-4057qib7 11892 26 + + CC cord-005453-4057qib7 11892 27 cells cell NNS cord-005453-4057qib7 11892 28 act act VBP cord-005453-4057qib7 11892 29 as as IN cord-005453-4057qib7 11892 30 modulatory modulatory JJ cord-005453-4057qib7 11892 31 and and CC cord-005453-4057qib7 11892 32 regulatory regulatory JJ cord-005453-4057qib7 11892 33 cells cell NNS cord-005453-4057qib7 11892 34 . . . cord-005453-4057qib7 11893 1 The the DT cord-005453-4057qib7 11893 2 early early JJ cord-005453-4057qib7 11893 3 post post JJ cord-005453-4057qib7 11893 4 - - JJ cord-005453-4057qib7 11893 5 HSCT hsct JJ cord-005453-4057qib7 11893 6 ratio ratio NN cord-005453-4057qib7 11893 7 between between IN cord-005453-4057qib7 11893 8 these these DT cord-005453-4057qib7 11893 9 cellular cellular JJ cord-005453-4057qib7 11893 10 subsets subset NNS cord-005453-4057qib7 11893 11 may may MD cord-005453-4057qib7 11893 12 be be VB cord-005453-4057qib7 11893 13 an an DT cord-005453-4057qib7 11893 14 indicator indicator NN cord-005453-4057qib7 11893 15 of of IN cord-005453-4057qib7 11893 16 Graft Graft NNP cord-005453-4057qib7 11893 17 vs vs IN cord-005453-4057qib7 11893 18 - - HYPH cord-005453-4057qib7 11893 19 Tumor tumor NN cord-005453-4057qib7 11893 20 ( ( -LRB- cord-005453-4057qib7 11893 21 GVT GVT NNP cord-005453-4057qib7 11893 22 ) ) -RRB- cord-005453-4057qib7 11893 23 effect effect NN cord-005453-4057qib7 11893 24 . . . cord-005453-4057qib7 11894 1 Methods method NNS cord-005453-4057qib7 11894 2 : : : cord-005453-4057qib7 11894 3 We -PRON- PRP cord-005453-4057qib7 11894 4 retrospectively retrospectively RB cord-005453-4057qib7 11894 5 revised revise VBD cord-005453-4057qib7 11894 6 the the DT cord-005453-4057qib7 11894 7 immune immune JJ cord-005453-4057qib7 11894 8 recovery recovery NN cord-005453-4057qib7 11894 9 of of IN cord-005453-4057qib7 11894 10 117 117 CD cord-005453-4057qib7 11894 11 allogeneic allogeneic NN cord-005453-4057qib7 11894 12 HSCT HSCT NNP cord-005453-4057qib7 11894 13 performed perform VBN cord-005453-4057qib7 11894 14 at at IN cord-005453-4057qib7 11894 15 our -PRON- PRP$ cord-005453-4057qib7 11894 16 Institution Institution NNP cord-005453-4057qib7 11894 17 from from IN cord-005453-4057qib7 11894 18 2013 2013 CD cord-005453-4057qib7 11894 19 to to IN cord-005453-4057qib7 11894 20 2017 2017 CD cord-005453-4057qib7 11894 21 , , , cord-005453-4057qib7 11894 22 analysed analyse VBN cord-005453-4057qib7 11894 23 on on IN cord-005453-4057qib7 11894 24 peripheral peripheral JJ cord-005453-4057qib7 11894 25 blood blood NN cord-005453-4057qib7 11894 26 by by IN cord-005453-4057qib7 11894 27 multiparametric multiparametric JJ cord-005453-4057qib7 11894 28 flow flow NN cord-005453-4057qib7 11894 29 cytometry cytometry NN cord-005453-4057qib7 11894 30 lymphocyte lymphocyte NN cord-005453-4057qib7 11894 31 subpopulations subpopulation NNS cord-005453-4057qib7 11894 32 panel panel NN cord-005453-4057qib7 11894 33 . . . cord-005453-4057qib7 11895 1 DIagnosis DIagnosis NNP cord-005453-4057qib7 11895 2 were be VBD cord-005453-4057qib7 11895 3 Acute acute JJ cord-005453-4057qib7 11895 4 Leukemias Leukemias NNPS cord-005453-4057qib7 11895 5 ( ( -LRB- cord-005453-4057qib7 11895 6 69 69 CD cord-005453-4057qib7 11895 7 % % NN cord-005453-4057qib7 11895 8 ) ) -RRB- cord-005453-4057qib7 11895 9 , , , cord-005453-4057qib7 11895 10 Chronic Chronic NNP cord-005453-4057qib7 11895 11 Myeloproliferative Myeloproliferative NNP cord-005453-4057qib7 11895 12 Neoplasms Neoplasms NNP cord-005453-4057qib7 11895 13 ( ( -LRB- cord-005453-4057qib7 11895 14 10 10 CD cord-005453-4057qib7 11895 15 % % NN cord-005453-4057qib7 11895 16 ) ) -RRB- cord-005453-4057qib7 11895 17 , , , cord-005453-4057qib7 11895 18 Lymphomas lymphoma NNS cord-005453-4057qib7 11895 19 ( ( -LRB- cord-005453-4057qib7 11895 20 10 10 CD cord-005453-4057qib7 11895 21 % % NN cord-005453-4057qib7 11895 22 ) ) -RRB- cord-005453-4057qib7 11895 23 , , , cord-005453-4057qib7 11895 24 Myelodysplastic Myelodysplastic NNP cord-005453-4057qib7 11895 25 Syndromes syndrome NNS cord-005453-4057qib7 11895 26 ( ( -LRB- cord-005453-4057qib7 11895 27 5 5 CD cord-005453-4057qib7 11895 28 % % NN cord-005453-4057qib7 11895 29 ) ) -RRB- cord-005453-4057qib7 11895 30 , , , cord-005453-4057qib7 11895 31 Multiple Multiple NNP cord-005453-4057qib7 11895 32 Myeloma Myeloma NNP cord-005453-4057qib7 11895 33 ( ( -LRB- cord-005453-4057qib7 11895 34 3 3 CD cord-005453-4057qib7 11895 35 % % NN cord-005453-4057qib7 11895 36 ) ) -RRB- cord-005453-4057qib7 11895 37 and and CC cord-005453-4057qib7 11895 38 Severe severe JJ cord-005453-4057qib7 11895 39 Aplastic Aplastic NNP cord-005453-4057qib7 11895 40 Anemia anemia NN cord-005453-4057qib7 11895 41 ( ( -LRB- cord-005453-4057qib7 11895 42 3 3 CD cord-005453-4057qib7 11895 43 % % NN cord-005453-4057qib7 11895 44 ) ) -RRB- cord-005453-4057qib7 11895 45 . . . cord-005453-4057qib7 11896 1 We -PRON- PRP cord-005453-4057qib7 11896 2 established establish VBD cord-005453-4057qib7 11896 3 2 2 CD cord-005453-4057qib7 11896 4 early early JJ cord-005453-4057qib7 11896 5 time time NN cord-005453-4057qib7 11896 6 - - HYPH cord-005453-4057qib7 11896 7 points point NNS cord-005453-4057qib7 11896 8 of of IN cord-005453-4057qib7 11896 9 evaluation evaluation NN cord-005453-4057qib7 11896 10 , , , cord-005453-4057qib7 11896 11 30 30 CD cord-005453-4057qib7 11896 12 and and CC cord-005453-4057qib7 11896 13 60 60 CD cord-005453-4057qib7 11896 14 days day NNS cord-005453-4057qib7 11896 15 from from IN cord-005453-4057qib7 11896 16 the the DT cord-005453-4057qib7 11896 17 graft graft NN cord-005453-4057qib7 11896 18 infusion infusion NN cord-005453-4057qib7 11896 19 , , , cord-005453-4057qib7 11896 20 to to TO cord-005453-4057qib7 11896 21 analyse analyse VB cord-005453-4057qib7 11896 22 the the DT cord-005453-4057qib7 11896 23 differences difference NNS cord-005453-4057qib7 11896 24 in in IN cord-005453-4057qib7 11896 25 disease disease NN cord-005453-4057qib7 11896 26 free free JJ cord-005453-4057qib7 11896 27 survival survival NN cord-005453-4057qib7 11896 28 ( ( -LRB- cord-005453-4057qib7 11896 29 DFS DFS NNP cord-005453-4057qib7 11896 30 ) ) -RRB- cord-005453-4057qib7 11896 31 and and CC cord-005453-4057qib7 11896 32 overall overall JJ cord-005453-4057qib7 11896 33 survival survival NN cord-005453-4057qib7 11896 34 ( ( -LRB- cord-005453-4057qib7 11896 35 OS OS NNP cord-005453-4057qib7 11896 36 ) ) -RRB- cord-005453-4057qib7 11896 37 between between IN cord-005453-4057qib7 11896 38 patients patient NNS cord-005453-4057qib7 11896 39 according accord VBG cord-005453-4057qib7 11896 40 to to IN cord-005453-4057qib7 11896 41 the the DT cord-005453-4057qib7 11896 42 CD3 CD3 NNP cord-005453-4057qib7 11896 43 + + SYM cord-005453-4057qib7 11896 44 CD8 CD8 NNP cord-005453-4057qib7 11896 45 + + CC cord-005453-4057qib7 11897 1 x x SYM cord-005453-4057qib7 11897 2 CD3 CD3 NNP cord-005453-4057qib7 11897 3 -CD56 -cd56 NN cord-005453-4057qib7 11898 1 + + CC cord-005453-4057qib7 11898 2 / / SYM cord-005453-4057qib7 11898 3 CD3 CD3 NNP cord-005453-4057qib7 11898 4 + + CC cord-005453-4057qib7 11898 5 CD4 CD4 NNP cord-005453-4057qib7 11898 6 + + CC cord-005453-4057qib7 11898 7 ratio ratio NN cord-005453-4057qib7 11898 8 . . . cord-005453-4057qib7 11899 1 Results result NNS cord-005453-4057qib7 11899 2 : : : cord-005453-4057qib7 11900 1 Median median JJ cord-005453-4057qib7 11900 2 ratio ratio NN cord-005453-4057qib7 11900 3 at at IN cord-005453-4057qib7 11900 4 +60 +60 CD cord-005453-4057qib7 11900 5 days day NNS cord-005453-4057qib7 11900 6 was be VBD cord-005453-4057qib7 11900 7 of of IN cord-005453-4057qib7 11900 8 0,5667 0,5667 CD cord-005453-4057qib7 11900 9 . . . cord-005453-4057qib7 11901 1 At at IN cord-005453-4057qib7 11901 2 this this DT cord-005453-4057qib7 11901 3 time time NN cord-005453-4057qib7 11901 4 point point NN cord-005453-4057qib7 11901 5 , , , cord-005453-4057qib7 11901 6 patients patient NNS cord-005453-4057qib7 11901 7 who who WP cord-005453-4057qib7 11901 8 showed show VBD cord-005453-4057qib7 11901 9 the the DT cord-005453-4057qib7 11901 10 ratio ratio NN cord-005453-4057qib7 11901 11 higher high JJR cord-005453-4057qib7 11901 12 than than IN cord-005453-4057qib7 11901 13 the the DT cord-005453-4057qib7 11901 14 median median NN cord-005453-4057qib7 11901 15 had have VBD cord-005453-4057qib7 11901 16 both both CC cord-005453-4057qib7 11901 17 a a DT cord-005453-4057qib7 11901 18 better well JJR cord-005453-4057qib7 11901 19 DFS DFS NNP cord-005453-4057qib7 11901 20 ( ( -LRB- cord-005453-4057qib7 11901 21 median median JJ cord-005453-4057qib7 11901 22 DFS DFS NNP cord-005453-4057qib7 11901 23 time time NN cord-005453-4057qib7 11901 24 not not RB cord-005453-4057qib7 11901 25 reached reach VBN cord-005453-4057qib7 11901 26 vs vs IN cord-005453-4057qib7 11901 27 12 12 CD cord-005453-4057qib7 11901 28 months month NNS cord-005453-4057qib7 11901 29 ; ; : cord-005453-4057qib7 11901 30 p p NN cord-005453-4057qib7 11901 31 = = SYM cord-005453-4057qib7 11901 32 0,018 0,018 CD cord-005453-4057qib7 11901 33 ) ) -RRB- cord-005453-4057qib7 11902 1 ( ( -LRB- cord-005453-4057qib7 11902 2 Figure figure NN cord-005453-4057qib7 11902 3 1 1 CD cord-005453-4057qib7 11902 4 ) ) -RRB- cord-005453-4057qib7 11902 5 and and CC cord-005453-4057qib7 11902 6 OS OS NNP cord-005453-4057qib7 11902 7 ( ( -LRB- cord-005453-4057qib7 11902 8 median median JJ cord-005453-4057qib7 11902 9 OS OS NNP cord-005453-4057qib7 11902 10 time time NN cord-005453-4057qib7 11902 11 not not RB cord-005453-4057qib7 11902 12 reached reach VBN cord-005453-4057qib7 11902 13 vs vs IN cord-005453-4057qib7 11902 14 13 13 CD cord-005453-4057qib7 11902 15 months month NNS cord-005453-4057qib7 11902 16 ; ; : cord-005453-4057qib7 11902 17 p p NN cord-005453-4057qib7 11902 18 = = SYM cord-005453-4057qib7 11902 19 0,014 0,014 CD cord-005453-4057qib7 11902 20 ) ) -RRB- cord-005453-4057qib7 11902 21 . . . cord-005453-4057qib7 11903 1 Likewise likewise RB cord-005453-4057qib7 11903 2 , , , cord-005453-4057qib7 11903 3 ratio ratio NN cord-005453-4057qib7 11903 4 at at IN cord-005453-4057qib7 11903 5 +30 +30 CD cord-005453-4057qib7 11903 6 showed show VBD cord-005453-4057qib7 11903 7 an an DT cord-005453-4057qib7 11903 8 advantage advantage NN cord-005453-4057qib7 11903 9 on on IN cord-005453-4057qib7 11903 10 DFS DFS NNP cord-005453-4057qib7 11903 11 ( ( -LRB- cord-005453-4057qib7 11903 12 p p NN cord-005453-4057qib7 11903 13 = = SYM cord-005453-4057qib7 11903 14 0,027 0,027 CD cord-005453-4057qib7 11903 15 ) ) -RRB- cord-005453-4057qib7 11903 16 , , , cord-005453-4057qib7 11903 17 and and CC cord-005453-4057qib7 11903 18 not not RB cord-005453-4057qib7 11903 19 on on IN cord-005453-4057qib7 11903 20 OS OS NNP cord-005453-4057qib7 11903 21 ( ( -LRB- cord-005453-4057qib7 11903 22 p p NN cord-005453-4057qib7 11903 23 = = SYM cord-005453-4057qib7 11903 24 0,06 0,06 CD cord-005453-4057qib7 11903 25 ) ) -RRB- cord-005453-4057qib7 11903 26 . . . cord-005453-4057qib7 11904 1 Other other JJ cord-005453-4057qib7 11904 2 factors factor NNS cord-005453-4057qib7 11904 3 possibly possibly RB cord-005453-4057qib7 11904 4 affecting affect VBG cord-005453-4057qib7 11904 5 both both CC cord-005453-4057qib7 11904 6 DFS DFS NNP cord-005453-4057qib7 11904 7 and and CC cord-005453-4057qib7 11904 8 OS OS NNP cord-005453-4057qib7 11904 9 were be VBD cord-005453-4057qib7 11904 10 analysed analyse VBN cord-005453-4057qib7 11904 11 in in IN cord-005453-4057qib7 11904 12 univariate univariate JJ cord-005453-4057qib7 11904 13 analysis analysis NN cord-005453-4057qib7 11904 14 , , , cord-005453-4057qib7 11904 15 such such JJ cord-005453-4057qib7 11904 16 as as IN cord-005453-4057qib7 11904 17 the the DT cord-005453-4057qib7 11904 18 use use NN cord-005453-4057qib7 11904 19 of of IN cord-005453-4057qib7 11904 20 antithymocyte antithymocyte NNP cord-005453-4057qib7 11904 21 globulin globulin NN cord-005453-4057qib7 11904 22 ( ( -LRB- cord-005453-4057qib7 11904 23 ATG ATG NNP cord-005453-4057qib7 11904 24 ) ) -RRB- cord-005453-4057qib7 11904 25 , , , cord-005453-4057qib7 11904 26 conditioning conditioning NN cord-005453-4057qib7 11904 27 regimen regimen NN cord-005453-4057qib7 11904 28 intensity intensity NN cord-005453-4057qib7 11904 29 , , , cord-005453-4057qib7 11904 30 graft graft NN cord-005453-4057qib7 11904 31 source source NN cord-005453-4057qib7 11904 32 , , , cord-005453-4057qib7 11904 33 HLA HLA NNP cord-005453-4057qib7 11904 34 - - HYPH cord-005453-4057qib7 11904 35 matching matching NN cord-005453-4057qib7 11904 36 and and CC cord-005453-4057qib7 11904 37 disease disease NN cord-005453-4057qib7 11904 38 status status NN cord-005453-4057qib7 11904 39 at at IN cord-005453-4057qib7 11904 40 HSCT HSCT NNP cord-005453-4057qib7 11904 41 , , , cord-005453-4057qib7 11904 42 the the DT cord-005453-4057qib7 11904 43 latter latter JJ cord-005453-4057qib7 11904 44 being be VBG cord-005453-4057qib7 11904 45 the the DT cord-005453-4057qib7 11904 46 only only JJ cord-005453-4057qib7 11904 47 variable variable NN cord-005453-4057qib7 11904 48 with with IN cord-005453-4057qib7 11904 49 a a DT cord-005453-4057qib7 11904 50 significantly significantly RB cord-005453-4057qib7 11904 51 detrimental detrimental JJ cord-005453-4057qib7 11904 52 impact impact NN cord-005453-4057qib7 11904 53 on on IN cord-005453-4057qib7 11904 54 both both CC cord-005453-4057qib7 11904 55 OS OS NNP cord-005453-4057qib7 11904 56 and and CC cord-005453-4057qib7 11904 57 DFS DFS NNP cord-005453-4057qib7 11904 58 . . . cord-005453-4057qib7 11905 1 Disease disease NN cord-005453-4057qib7 11905 2 status status NN cord-005453-4057qib7 11905 3 was be VBD cord-005453-4057qib7 11905 4 confirmed confirm VBN cord-005453-4057qib7 11905 5 an an DT cord-005453-4057qib7 11905 6 independent independent JJ cord-005453-4057qib7 11905 7 valriable valriable NN cord-005453-4057qib7 11905 8 associated associate VBN cord-005453-4057qib7 11905 9 with with IN cord-005453-4057qib7 11905 10 both both DT cord-005453-4057qib7 11905 11 DFS DFS NNP cord-005453-4057qib7 11905 12 and and CC cord-005453-4057qib7 11905 13 OS OS NNP cord-005453-4057qib7 11905 14 as as RB cord-005453-4057qib7 11905 15 well well RB cord-005453-4057qib7 11905 16 as as IN cord-005453-4057qib7 11905 17 +60 +60 CD cord-005453-4057qib7 11905 18 ratio ratio NN cord-005453-4057qib7 11905 19 both both CC cord-005453-4057qib7 11905 20 on on IN cord-005453-4057qib7 11905 21 DFS DFS NNP cord-005453-4057qib7 11905 22 ( ( -LRB- cord-005453-4057qib7 11905 23 Hazard Hazard NNP cord-005453-4057qib7 11905 24 Ratio Ratio NNP cord-005453-4057qib7 11905 25 [ [ -LRB- cord-005453-4057qib7 11905 26 HR HR NNP cord-005453-4057qib7 11905 27 ] ] -RRB- cord-005453-4057qib7 11905 28 -2,721 -2,721 . cord-005453-4057qib7 11906 1 ; ; : cord-005453-4057qib7 11906 2 p p NN cord-005453-4057qib7 11906 3 = = SYM cord-005453-4057qib7 11906 4 0,015 0,015 CD cord-005453-4057qib7 11906 5 ) ) -RRB- cord-005453-4057qib7 11907 1 and and CC cord-005453-4057qib7 11907 2 OS OS NNP cord-005453-4057qib7 11907 3 ( ( -LRB- cord-005453-4057qib7 11907 4 HR HR NNP cord-005453-4057qib7 11907 5 2,627 2,627 CD cord-005453-4057qib7 11907 6 ; ; : cord-005453-4057qib7 11907 7 p p NN cord-005453-4057qib7 11907 8 = = SYM cord-005453-4057qib7 11907 9 0,022 0,022 CD cord-005453-4057qib7 11907 10 ) ) -RRB- cord-005453-4057qib7 11907 11 . . . cord-005453-4057qib7 11908 1 Conclusions conclusion NNS cord-005453-4057qib7 11908 2 : : : cord-005453-4057qib7 11909 1 Our -PRON- PRP$ cord-005453-4057qib7 11909 2 data datum NNS cord-005453-4057qib7 11909 3 show show VBP cord-005453-4057qib7 11909 4 that that IN cord-005453-4057qib7 11909 5 CD3 CD3 NNP cord-005453-4057qib7 11909 6 + + SYM cord-005453-4057qib7 11909 7 CD8 CD8 NNP cord-005453-4057qib7 11909 8 + + CC cord-005453-4057qib7 11909 9 x x SYM cord-005453-4057qib7 11909 10 CD3 CD3 NNP cord-005453-4057qib7 11909 11 -CD56 -cd56 NN cord-005453-4057qib7 11909 12 + + NNP cord-005453-4057qib7 11909 13 / / SYM cord-005453-4057qib7 11909 14 CD3 CD3 NNP cord-005453-4057qib7 11910 1 + + CC cord-005453-4057qib7 11911 1 CD4 CD4 NNP cord-005453-4057qib7 11911 2 + + CC cord-005453-4057qib7 11911 3 ratio ratio NN cord-005453-4057qib7 11911 4 assessed assess VBN cord-005453-4057qib7 11911 5 at at IN cord-005453-4057qib7 11911 6 +60 +60 NNP cord-005453-4057qib7 11911 7 is be VBZ cord-005453-4057qib7 11911 8 and and CC cord-005453-4057qib7 11911 9 independent independent JJ cord-005453-4057qib7 11911 10 predictor predictor NN cord-005453-4057qib7 11911 11 of of IN cord-005453-4057qib7 11911 12 transplant transplant NN cord-005453-4057qib7 11911 13 outcome outcome NN cord-005453-4057qib7 11911 14 , , , cord-005453-4057qib7 11911 15 possibly possibly RB cord-005453-4057qib7 11911 16 representing represent VBG cord-005453-4057qib7 11911 17 a a DT cord-005453-4057qib7 11911 18 row row NN cord-005453-4057qib7 11911 19 indicator indicator NN cord-005453-4057qib7 11911 20 of of IN cord-005453-4057qib7 11911 21 anti anti JJ cord-005453-4057qib7 11911 22 - - JJ cord-005453-4057qib7 11911 23 leukemic leukemic JJ cord-005453-4057qib7 11911 24 immune immune JJ cord-005453-4057qib7 11911 25 surveillance surveillance NN cord-005453-4057qib7 11911 26 . . . cord-005453-4057qib7 11912 1 The the DT cord-005453-4057qib7 11912 2 integration integration NN cord-005453-4057qib7 11912 3 of of IN cord-005453-4057qib7 11912 4 this this DT cord-005453-4057qib7 11912 5 index index NN cord-005453-4057qib7 11912 6 with with IN cord-005453-4057qib7 11912 7 other other JJ cord-005453-4057qib7 11912 8 known know VBN cord-005453-4057qib7 11912 9 outcome outcome NN cord-005453-4057qib7 11912 10 predictors predictor NNS cord-005453-4057qib7 11912 11 may may MD cord-005453-4057qib7 11912 12 help help VB cord-005453-4057qib7 11912 13 in in IN cord-005453-4057qib7 11912 14 improving improve VBG cord-005453-4057qib7 11912 15 the the DT cord-005453-4057qib7 11912 16 management management NN cord-005453-4057qib7 11912 17 of of IN cord-005453-4057qib7 11912 18 post post JJ cord-005453-4057qib7 11912 19 - - JJ cord-005453-4057qib7 11912 20 transplant transplant JJ cord-005453-4057qib7 11912 21 phase phase NN cord-005453-4057qib7 11912 22 . . . cord-005453-4057qib7 11913 1 [ [ -LRB- cord-005453-4057qib7 11913 2 [ [ -LRB- cord-005453-4057qib7 11913 3 P524 P524 NNP cord-005453-4057qib7 11913 4 Image image NN cord-005453-4057qib7 11913 5 ] ] -RRB- cord-005453-4057qib7 11913 6 1 1 CD cord-005453-4057qib7 11913 7 . . . cord-005453-4057qib7 11914 1 Figure figure NN cord-005453-4057qib7 11914 2 1 1 CD cord-005453-4057qib7 11914 3 Background background NN cord-005453-4057qib7 11914 4 : : : cord-005453-4057qib7 11915 1 Allogeneic allogeneic IN cord-005453-4057qib7 11915 2 stem stem VBP cord-005453-4057qib7 11915 3 cell cell NN cord-005453-4057qib7 11915 4 transplantation transplantation NN cord-005453-4057qib7 11915 5 ( ( -LRB- cord-005453-4057qib7 11915 6 alo alo NNP cord-005453-4057qib7 11915 7 - - HYPH cord-005453-4057qib7 11915 8 HSCT HSCT NNP cord-005453-4057qib7 11915 9 ) ) -RRB- cord-005453-4057qib7 11915 10 is be VBZ cord-005453-4057qib7 11915 11 a a DT cord-005453-4057qib7 11915 12 curative curative JJ cord-005453-4057qib7 11915 13 treatment treatment NN cord-005453-4057qib7 11916 1 but but CC cord-005453-4057qib7 11916 2 it -PRON- PRP cord-005453-4057qib7 11916 3 is be VBZ cord-005453-4057qib7 11916 4 associated associate VBN cord-005453-4057qib7 11916 5 with with IN cord-005453-4057qib7 11916 6 lifethreatening lifethreatening JJ cord-005453-4057qib7 11916 7 complications complication NNS cord-005453-4057qib7 11916 8 . . . cord-005453-4057qib7 11917 1 Most Most JJS cord-005453-4057qib7 11917 2 deaths death NNS cord-005453-4057qib7 11917 3 are be VBP cord-005453-4057qib7 11917 4 due due JJ cord-005453-4057qib7 11917 5 to to IN cord-005453-4057qib7 11917 6 relapse relapse NN cord-005453-4057qib7 11917 7 , , , cord-005453-4057qib7 11917 8 graft graft NN cord-005453-4057qib7 11917 9 versus versus IN cord-005453-4057qib7 11917 10 host host NN cord-005453-4057qib7 11917 11 disease disease NN cord-005453-4057qib7 11917 12 ( ( -LRB- cord-005453-4057qib7 11917 13 GvHD GvHD NNP cord-005453-4057qib7 11917 14 ) ) -RRB- cord-005453-4057qib7 11917 15 and and CC cord-005453-4057qib7 11917 16 infection infection NN cord-005453-4057qib7 11917 17 . . . cord-005453-4057qib7 11918 1 The the DT cord-005453-4057qib7 11918 2 pattern pattern NN cord-005453-4057qib7 11918 3 and and CC cord-005453-4057qib7 11918 4 quality quality NN cord-005453-4057qib7 11918 5 of of IN cord-005453-4057qib7 11918 6 the the DT cord-005453-4057qib7 11918 7 immune immune JJ cord-005453-4057qib7 11918 8 reconstitution reconstitution NN cord-005453-4057qib7 11918 9 ( ( -LRB- cord-005453-4057qib7 11918 10 IR IR NNP cord-005453-4057qib7 11918 11 ) ) -RRB- cord-005453-4057qib7 11918 12 after after IN cord-005453-4057qib7 11918 13 transplantation transplantation NN cord-005453-4057qib7 11918 14 may may MD cord-005453-4057qib7 11918 15 affect affect VB cord-005453-4057qib7 11918 16 these these DT cord-005453-4057qib7 11918 17 outcomes outcome NNS cord-005453-4057qib7 11918 18 . . . cord-005453-4057qib7 11919 1 However however RB cord-005453-4057qib7 11919 2 , , , cord-005453-4057qib7 11919 3 there there EX cord-005453-4057qib7 11919 4 are be VBP cord-005453-4057qib7 11919 5 limited limited JJ cord-005453-4057qib7 11919 6 data datum NNS cord-005453-4057qib7 11919 7 on on IN cord-005453-4057qib7 11919 8 the the DT cord-005453-4057qib7 11919 9 association association NN cord-005453-4057qib7 11919 10 of of IN cord-005453-4057qib7 11919 11 the the DT cord-005453-4057qib7 11919 12 quality quality NN cord-005453-4057qib7 11919 13 of of IN cord-005453-4057qib7 11919 14 the the DT cord-005453-4057qib7 11919 15 IR IR NNP cord-005453-4057qib7 11919 16 and and CC cord-005453-4057qib7 11919 17 either either CC cord-005453-4057qib7 11919 18 the the DT cord-005453-4057qib7 11919 19 development development NN cord-005453-4057qib7 11919 20 of of IN cord-005453-4057qib7 11919 21 GVHD GVHD NNP cord-005453-4057qib7 11919 22 and and CC cord-005453-4057qib7 11919 23 survival survival NN cord-005453-4057qib7 11919 24 . . . cord-005453-4057qib7 11920 1 Methods method NNS cord-005453-4057qib7 11920 2 : : : cord-005453-4057qib7 11920 3 Eighty eighty CD cord-005453-4057qib7 11920 4 - - HYPH cord-005453-4057qib7 11920 5 five five CD cord-005453-4057qib7 11920 6 patients patient NNS cord-005453-4057qib7 11920 7 who who WP cord-005453-4057qib7 11920 8 received receive VBD cord-005453-4057qib7 11920 9 a a DT cord-005453-4057qib7 11920 10 non non JJ cord-005453-4057qib7 11920 11 T t NN cord-005453-4057qib7 11920 12 - - HYPH cord-005453-4057qib7 11920 13 cell cell NN cord-005453-4057qib7 11920 14 depleted deplete VBN cord-005453-4057qib7 11920 15 alo alo NNP cord-005453-4057qib7 11920 16 - - HYPH cord-005453-4057qib7 11920 17 HSCT HSCT NNP cord-005453-4057qib7 11920 18 in in IN cord-005453-4057qib7 11920 19 our -PRON- PRP$ cord-005453-4057qib7 11920 20 center center NN cord-005453-4057qib7 11920 21 from from IN cord-005453-4057qib7 11920 22 2011 2011 CD cord-005453-4057qib7 11920 23 to to IN cord-005453-4057qib7 11920 24 2014 2014 CD cord-005453-4057qib7 11920 25 were be VBD cord-005453-4057qib7 11920 26 prospectively prospectively RB cord-005453-4057qib7 11920 27 studied study VBN cord-005453-4057qib7 11920 28 . . . cord-005453-4057qib7 11921 1 Most Most JJS cord-005453-4057qib7 11921 2 patients patient NNS cord-005453-4057qib7 11921 3 received receive VBD cord-005453-4057qib7 11921 4 HLA HLA NNP cord-005453-4057qib7 11921 5 - - HYPH cord-005453-4057qib7 11921 6 identical identical JJ cord-005453-4057qib7 11921 7 grafts graft NNS cord-005453-4057qib7 11921 8 . . . cord-005453-4057qib7 11922 1 Total total JJ cord-005453-4057qib7 11922 2 CD4 CD4 NNP cord-005453-4057qib7 11922 3 + + CC cord-005453-4057qib7 11922 4 and and CC cord-005453-4057qib7 11922 5 CD8 CD8 NNP cord-005453-4057qib7 11922 6 + + CC cord-005453-4057qib7 11922 7 T T NNP cord-005453-4057qib7 11922 8 cells cell NNS cord-005453-4057qib7 11922 9 , , , cord-005453-4057qib7 11923 1 CCR7+CD4 CCR7+CD4 NNP cord-005453-4057qib7 11923 2 + + CC cord-005453-4057qib7 11924 1 and and CC cord-005453-4057qib7 11924 2 CCR7+CD8 CCR7+CD8 NNP cord-005453-4057qib7 11925 1 + + JJ cord-005453-4057qib7 11925 2 ( ( -LRB- cord-005453-4057qib7 11925 3 which which WDT cord-005453-4057qib7 11925 4 include include VBP cord-005453-4057qib7 11925 5 both both DT cord-005453-4057qib7 11925 6 naïve naïve JJ cord-005453-4057qib7 11925 7 and and CC cord-005453-4057qib7 11925 8 central central JJ cord-005453-4057qib7 11925 9 memory memory NN cord-005453-4057qib7 11925 10 T T NNP cord-005453-4057qib7 11925 11 cells cell NNS cord-005453-4057qib7 11925 12 ) ) -RRB- cord-005453-4057qib7 11925 13 and and CC cord-005453-4057qib7 11925 14 naïve naïve JJ cord-005453-4057qib7 11925 15 CCR7+CD62L+ CCR7+CD62L+ NNS cord-005453-4057qib7 11925 16 T t NN cord-005453-4057qib7 11925 17 lymphocytes lymphocyte NNS cord-005453-4057qib7 11925 18 were be VBD cord-005453-4057qib7 11925 19 quantified quantify VBN cord-005453-4057qib7 11925 20 by by IN cord-005453-4057qib7 11925 21 flow flow NN cord-005453-4057qib7 11925 22 cytometry cytometry NN cord-005453-4057qib7 11925 23 . . . cord-005453-4057qib7 11926 1 Data datum NNS cord-005453-4057qib7 11926 2 were be VBD cord-005453-4057qib7 11926 3 collected collect VBN cord-005453-4057qib7 11926 4 at at IN cord-005453-4057qib7 11926 5 days day NNS cord-005453-4057qib7 11926 6 +30 +30 CD cord-005453-4057qib7 11926 7 , , , cord-005453-4057qib7 11926 8 +60 +60 NNP cord-005453-4057qib7 11926 9 , , , cord-005453-4057qib7 11926 10 +90 +90 CD cord-005453-4057qib7 11926 11 , , , cord-005453-4057qib7 11926 12 +180 +180 NNP cord-005453-4057qib7 11926 13 and and CC cord-005453-4057qib7 11926 14 +360 +360 NNP cord-005453-4057qib7 11926 15 after after IN cord-005453-4057qib7 11926 16 alo alo JJ cord-005453-4057qib7 11926 17 - - HYPH cord-005453-4057qib7 11926 18 HSCT HSCT NNP cord-005453-4057qib7 11926 19 . . . cord-005453-4057qib7 11927 1 The the DT cord-005453-4057qib7 11927 2 association association NN cord-005453-4057qib7 11927 3 between between IN cord-005453-4057qib7 11927 4 IR IR NNP cord-005453-4057qib7 11927 5 and and CC cord-005453-4057qib7 11927 6 the the DT cord-005453-4057qib7 11927 7 GVHD GVHD NNP cord-005453-4057qib7 11927 8 was be VBD cord-005453-4057qib7 11927 9 studied study VBN cord-005453-4057qib7 11927 10 through through IN cord-005453-4057qib7 11927 11 an an DT cord-005453-4057qib7 11927 12 ANOVA anova NN cord-005453-4057qib7 11927 13 . . . cord-005453-4057qib7 11928 1 For for IN cord-005453-4057qib7 11928 2 the the DT cord-005453-4057qib7 11928 3 multivariate multivariate JJ cord-005453-4057qib7 11928 4 analysis analysis NN cord-005453-4057qib7 11928 5 , , , cord-005453-4057qib7 11928 6 a a DT cord-005453-4057qib7 11928 7 logistic logistic JJ cord-005453-4057qib7 11928 8 regression regression NN cord-005453-4057qib7 11928 9 was be VBD cord-005453-4057qib7 11928 10 performed perform VBN cord-005453-4057qib7 11928 11 including include VBG cord-005453-4057qib7 11928 12 those those DT cord-005453-4057qib7 11928 13 confusing confuse VBG cord-005453-4057qib7 11928 14 clinical clinical JJ cord-005453-4057qib7 11928 15 variables variable NNS cord-005453-4057qib7 11928 16 that that WDT cord-005453-4057qib7 11928 17 were be VBD cord-005453-4057qib7 11928 18 significant significant JJ cord-005453-4057qib7 11928 19 in in IN cord-005453-4057qib7 11928 20 the the DT cord-005453-4057qib7 11928 21 univariate univariate JJ cord-005453-4057qib7 11928 22 analysis analysis NN cord-005453-4057qib7 11928 23 ( ( -LRB- cord-005453-4057qib7 11928 24 p≤0.10 p≤0.10 NN cord-005453-4057qib7 11928 25 ) ) -RRB- cord-005453-4057qib7 11928 26 . . . cord-005453-4057qib7 11929 1 The the DT cord-005453-4057qib7 11929 2 study study NN cord-005453-4057qib7 11929 3 of of IN cord-005453-4057qib7 11929 4 overall overall JJ cord-005453-4057qib7 11929 5 survival survival NN cord-005453-4057qib7 11929 6 ( ( -LRB- cord-005453-4057qib7 11929 7 OS OS NNP cord-005453-4057qib7 11929 8 ) ) -RRB- cord-005453-4057qib7 11929 9 versus versus IN cord-005453-4057qib7 11929 10 IR IR NNP cord-005453-4057qib7 11929 11 was be VBD cord-005453-4057qib7 11929 12 performed perform VBN cord-005453-4057qib7 11929 13 with with IN cord-005453-4057qib7 11929 14 a a DT cord-005453-4057qib7 11929 15 cox cox NNP cord-005453-4057qib7 11929 16 regression regression NN cord-005453-4057qib7 11929 17 model model NN cord-005453-4057qib7 11929 18 . . . cord-005453-4057qib7 11930 1 Results result NNS cord-005453-4057qib7 11930 2 : : : cord-005453-4057qib7 11931 1 Total total JJ cord-005453-4057qib7 11931 2 CD3 CD3 NNP cord-005453-4057qib7 11931 3 + + CC cord-005453-4057qib7 11931 4 T t NN cord-005453-4057qib7 11931 5 lymphocytes lymphocyte NNS cord-005453-4057qib7 11931 6 reached reach VBD cord-005453-4057qib7 11931 7 normal normal JJ cord-005453-4057qib7 11931 8 numbers number NNS cord-005453-4057qib7 11931 9 within within IN cord-005453-4057qib7 11931 10 the the DT cord-005453-4057qib7 11931 11 first first JJ cord-005453-4057qib7 11931 12 two two CD cord-005453-4057qib7 11931 13 months month NNS cord-005453-4057qib7 11931 14 . . . cord-005453-4057qib7 11932 1 Median median JJ cord-005453-4057qib7 11932 2 T T NNP cord-005453-4057qib7 11932 3 CD8 CD8 NNP cord-005453-4057qib7 11932 4 + + CC cord-005453-4057qib7 11932 5 count count NN cord-005453-4057qib7 11932 6 was be VBD cord-005453-4057qib7 11933 1 263 263 CD cord-005453-4057qib7 11933 2 cells cell NNS cord-005453-4057qib7 11933 3 / / SYM cord-005453-4057qib7 11933 4 ul ul NN cord-005453-4057qib7 11933 5 after after IN cord-005453-4057qib7 11933 6 one one CD cord-005453-4057qib7 11933 7 month month NN cord-005453-4057qib7 11933 8 , , , cord-005453-4057qib7 11933 9 which which WDT cord-005453-4057qib7 11933 10 is be VBZ cord-005453-4057qib7 11933 11 within within IN cord-005453-4057qib7 11933 12 the the DT cord-005453-4057qib7 11933 13 normal normal JJ cord-005453-4057qib7 11933 14 range range NN cord-005453-4057qib7 11933 15 . . . cord-005453-4057qib7 11934 1 Conversely conversely RB cord-005453-4057qib7 11934 2 , , , cord-005453-4057qib7 11934 3 it -PRON- PRP cord-005453-4057qib7 11934 4 took take VBD cord-005453-4057qib7 11934 5 nearly nearly RB cord-005453-4057qib7 11934 6 one one CD cord-005453-4057qib7 11934 7 year year NN cord-005453-4057qib7 11934 8 to to TO cord-005453-4057qib7 11934 9 get get VB cord-005453-4057qib7 11934 10 normal normal JJ cord-005453-4057qib7 11934 11 counts count NNS cord-005453-4057qib7 11934 12 of of IN cord-005453-4057qib7 11934 13 CD4 CD4 NNP cord-005453-4057qib7 11934 14 + + CC cord-005453-4057qib7 11934 15 T t NN cord-005453-4057qib7 11934 16 cells cell NNS cord-005453-4057qib7 11934 17 ( ( -LRB- cord-005453-4057qib7 11934 18 542 542 CD cord-005453-4057qib7 11934 19 cells cell NNS cord-005453-4057qib7 11934 20 / / SYM cord-005453-4057qib7 11934 21 ul ul NN cord-005453-4057qib7 11934 22 ) ) -RRB- cord-005453-4057qib7 11934 23 . . . cord-005453-4057qib7 11935 1 The the DT cord-005453-4057qib7 11935 2 only only JJ cord-005453-4057qib7 11935 3 two two CD cord-005453-4057qib7 11935 4 clinical clinical JJ cord-005453-4057qib7 11935 5 parameters parameter NNS cord-005453-4057qib7 11935 6 conditioning condition VBG cord-005453-4057qib7 11935 7 a a DT cord-005453-4057qib7 11935 8 worse bad JJR cord-005453-4057qib7 11935 9 recovery recovery NN cord-005453-4057qib7 11935 10 of of IN cord-005453-4057qib7 11935 11 the the DT cord-005453-4057qib7 11935 12 CD4 CD4 NNP cord-005453-4057qib7 11935 13 + + CC cord-005453-4057qib7 11935 14 T t NN cord-005453-4057qib7 11935 15 cells cell NNS cord-005453-4057qib7 11935 16 were be VBD cord-005453-4057qib7 11935 17 the the DT cord-005453-4057qib7 11935 18 previous previous JJ cord-005453-4057qib7 11935 19 alosensitization alosensitization NN cord-005453-4057qib7 11935 20 of of IN cord-005453-4057qib7 11935 21 the the DT cord-005453-4057qib7 11935 22 donor donor NN cord-005453-4057qib7 11935 23 and and CC cord-005453-4057qib7 11935 24 the the DT cord-005453-4057qib7 11935 25 sex sex NN cord-005453-4057qib7 11935 26 , , , cord-005453-4057qib7 11935 27 being be VBG cord-005453-4057qib7 11935 28 female female JJ cord-005453-4057qib7 11935 29 donor donor NN cord-005453-4057qib7 11935 30 and and CC cord-005453-4057qib7 11935 31 male male NN cord-005453-4057qib7 11935 32 recipient recipient NN cord-005453-4057qib7 11935 33 the the DT cord-005453-4057qib7 11935 34 worst bad JJS cord-005453-4057qib7 11935 35 combination combination NN cord-005453-4057qib7 11935 36 for for IN cord-005453-4057qib7 11935 37 the the DT cord-005453-4057qib7 11935 38 IR IR NNP cord-005453-4057qib7 11935 39 . . . cord-005453-4057qib7 11936 1 No no DT cord-005453-4057qib7 11936 2 parameters parameter NNS cord-005453-4057qib7 11936 3 influenced influence VBD cord-005453-4057qib7 11936 4 the the DT cord-005453-4057qib7 11936 5 quality quality NN cord-005453-4057qib7 11936 6 of of IN cord-005453-4057qib7 11936 7 the the DT cord-005453-4057qib7 11936 8 reconstitution reconstitution NN cord-005453-4057qib7 11936 9 of of IN cord-005453-4057qib7 11936 10 CD8 CD8 NNP cord-005453-4057qib7 11936 11 + + CC cord-005453-4057qib7 11936 12 T T NNP cord-005453-4057qib7 11936 13 cells cell NNS cord-005453-4057qib7 11936 14 . . . cord-005453-4057qib7 11937 1 Of of IN cord-005453-4057qib7 11937 2 note note NN cord-005453-4057qib7 11937 3 , , , cord-005453-4057qib7 11937 4 the the DT cord-005453-4057qib7 11937 5 age age NN cord-005453-4057qib7 11937 6 or or CC cord-005453-4057qib7 11937 7 the the DT cord-005453-4057qib7 11937 8 HLA HLA NNP cord-005453-4057qib7 11937 9 status status NN cord-005453-4057qib7 11937 10 did do VBD cord-005453-4057qib7 11937 11 not not RB cord-005453-4057qib7 11937 12 influence influence VB cord-005453-4057qib7 11937 13 the the DT cord-005453-4057qib7 11937 14 quality quality NN cord-005453-4057qib7 11937 15 of of IN cord-005453-4057qib7 11937 16 the the DT cord-005453-4057qib7 11937 17 IR IR NNP cord-005453-4057qib7 11937 18 . . . cord-005453-4057qib7 11938 1 When when WRB cord-005453-4057qib7 11938 2 the the DT cord-005453-4057qib7 11938 3 patients patient NNS cord-005453-4057qib7 11938 4 were be VBD cord-005453-4057qib7 11938 5 divided divide VBN cord-005453-4057qib7 11938 6 into into IN cord-005453-4057qib7 11938 7 GVHD GVHD NNP cord-005453-4057qib7 11938 8 and and CC cord-005453-4057qib7 11938 9 no no DT cord-005453-4057qib7 11938 10 GVHD GVHD NNP cord-005453-4057qib7 11938 11 , , , cord-005453-4057qib7 11938 12 we -PRON- PRP cord-005453-4057qib7 11938 13 found find VBD cord-005453-4057qib7 11938 14 no no DT cord-005453-4057qib7 11938 15 differences difference NNS cord-005453-4057qib7 11938 16 in in IN cord-005453-4057qib7 11938 17 the the DT cord-005453-4057qib7 11938 18 recovery recovery NN cord-005453-4057qib7 11938 19 of of IN cord-005453-4057qib7 11938 20 either either CC cord-005453-4057qib7 11938 21 the the DT cord-005453-4057qib7 11938 22 proportion proportion NN cord-005453-4057qib7 11938 23 or or CC cord-005453-4057qib7 11938 24 absolute absolute JJ cord-005453-4057qib7 11938 25 count count NN cord-005453-4057qib7 11938 26 of of IN cord-005453-4057qib7 11938 27 every every DT cord-005453-4057qib7 11938 28 T T NNP cord-005453-4057qib7 11938 29 cell cell NN cord-005453-4057qib7 11938 30 subpopulation subpopulation NN cord-005453-4057qib7 11938 31 , , , cord-005453-4057qib7 11938 32 including include VBG cord-005453-4057qib7 11938 33 total total JJ cord-005453-4057qib7 11938 34 T t NN cord-005453-4057qib7 11938 35 cells cell NNS cord-005453-4057qib7 11938 36 as as RB cord-005453-4057qib7 11938 37 well well RB cord-005453-4057qib7 11938 38 as as IN cord-005453-4057qib7 11938 39 naïve naïve JJ cord-005453-4057qib7 11938 40 / / SYM cord-005453-4057qib7 11938 41 central central JJ cord-005453-4057qib7 11938 42 memory memory NN cord-005453-4057qib7 11938 43 T T NNP cord-005453-4057qib7 11938 44 cells cell NNS cord-005453-4057qib7 11938 45 , , , cord-005453-4057qib7 11938 46 both both CC cord-005453-4057qib7 11938 47 CD4 CD4 NNP cord-005453-4057qib7 11938 48 + + CC cord-005453-4057qib7 11938 49 and and CC cord-005453-4057qib7 11938 50 CD8 CD8 NNP cord-005453-4057qib7 11938 51 + + CC cord-005453-4057qib7 11938 52 . . . cord-005453-4057qib7 11939 1 Finally finally RB cord-005453-4057qib7 11939 2 , , , cord-005453-4057qib7 11939 3 a a DT cord-005453-4057qib7 11939 4 multivariant multivariant JJ cord-005453-4057qib7 11939 5 analysis analysis NN cord-005453-4057qib7 11939 6 confirmed confirm VBD cord-005453-4057qib7 11939 7 that that IN cord-005453-4057qib7 11939 8 the the DT cord-005453-4057qib7 11939 9 absolute absolute JJ cord-005453-4057qib7 11939 10 counts count NNS cord-005453-4057qib7 11939 11 of of IN cord-005453-4057qib7 11939 12 CD4+CCR7 cd4+ccr7 NN cord-005453-4057qib7 11939 13 + + CC cord-005453-4057qib7 11939 14 T t NN cord-005453-4057qib7 11939 15 cells cell NNS cord-005453-4057qib7 11939 16 at at IN cord-005453-4057qib7 11939 17 day day NN cord-005453-4057qib7 11939 18 +90 +90 NFP cord-005453-4057qib7 11939 19 as as RB cord-005453-4057qib7 11939 20 well well RB cord-005453-4057qib7 11939 21 as as IN cord-005453-4057qib7 11939 22 the the DT cord-005453-4057qib7 11939 23 absolute absolute JJ cord-005453-4057qib7 11939 24 counts count NNS cord-005453-4057qib7 11939 25 of of IN cord-005453-4057qib7 11939 26 both both DT cord-005453-4057qib7 11939 27 CD4+CCR7 cd4+ccr7 NN cord-005453-4057qib7 11939 28 + + CC cord-005453-4057qib7 11939 29 T t NN cord-005453-4057qib7 11939 30 cells cell NNS cord-005453-4057qib7 11939 31 and and CC cord-005453-4057qib7 11939 32 naïve naïve JJ cord-005453-4057qib7 11939 33 CD4+CCR7+CD62L+ CD4+CCR7+CD62L+ NNS cord-005453-4057qib7 11939 34 at at IN cord-005453-4057qib7 11939 35 day day NN cord-005453-4057qib7 11939 36 +180 +180 NNP cord-005453-4057qib7 11939 37 were be VBD cord-005453-4057qib7 11939 38 associated associate VBN cord-005453-4057qib7 11939 39 with with IN cord-005453-4057qib7 11939 40 better well JJR cord-005453-4057qib7 11939 41 OS OS NNP cord-005453-4057qib7 11939 42 . . . cord-005453-4057qib7 11940 1 Conclusions conclusion NNS cord-005453-4057qib7 11940 2 : : : cord-005453-4057qib7 11941 1 In in IN cord-005453-4057qib7 11941 2 conclusion conclusion NN cord-005453-4057qib7 11941 3 , , , cord-005453-4057qib7 11941 4 neither neither CC cord-005453-4057qib7 11941 5 the the DT cord-005453-4057qib7 11941 6 development development NN cord-005453-4057qib7 11941 7 of of IN cord-005453-4057qib7 11941 8 GVHD GVHD NNP cord-005453-4057qib7 11941 9 nor nor CC cord-005453-4057qib7 11941 10 other other JJ cord-005453-4057qib7 11941 11 relevant relevant JJ cord-005453-4057qib7 11941 12 parameters parameter NNS cord-005453-4057qib7 11941 13 seem seem VBP cord-005453-4057qib7 11941 14 to to TO cord-005453-4057qib7 11941 15 play play VB cord-005453-4057qib7 11941 16 a a DT cord-005453-4057qib7 11941 17 determinant determinant JJ cord-005453-4057qib7 11941 18 role role NN cord-005453-4057qib7 11941 19 in in IN cord-005453-4057qib7 11941 20 the the DT cord-005453-4057qib7 11941 21 quality quality NN cord-005453-4057qib7 11941 22 of of IN cord-005453-4057qib7 11941 23 the the DT cord-005453-4057qib7 11941 24 IR IR NNP cord-005453-4057qib7 11941 25 . . . cord-005453-4057qib7 11942 1 To to IN cord-005453-4057qib7 11942 2 our -PRON- PRP$ cord-005453-4057qib7 11942 3 knowledge knowledge NN cord-005453-4057qib7 11942 4 this this DT cord-005453-4057qib7 11942 5 is be VBZ cord-005453-4057qib7 11942 6 the the DT cord-005453-4057qib7 11942 7 first first JJ cord-005453-4057qib7 11942 8 study study NN cord-005453-4057qib7 11942 9 which which WDT cord-005453-4057qib7 11942 10 demonstrate demonstrate VBP cord-005453-4057qib7 11942 11 a a DT cord-005453-4057qib7 11942 12 clear clear JJ cord-005453-4057qib7 11942 13 association association NN cord-005453-4057qib7 11942 14 between between IN cord-005453-4057qib7 11942 15 the the DT cord-005453-4057qib7 11942 16 recovery recovery NN cord-005453-4057qib7 11942 17 of of IN cord-005453-4057qib7 11942 18 naïve naïve JJ cord-005453-4057qib7 11942 19 CD4 CD4 NNP cord-005453-4057qib7 11942 20 + + CC cord-005453-4057qib7 11942 21 T t NN cord-005453-4057qib7 11942 22 cells cell NNS cord-005453-4057qib7 11942 23 measured measure VBN cord-005453-4057qib7 11942 24 by by IN cord-005453-4057qib7 11942 25 flow flow NN cord-005453-4057qib7 11942 26 cytometry cytometry NN cord-005453-4057qib7 11942 27 and and CC cord-005453-4057qib7 11942 28 the the DT cord-005453-4057qib7 11942 29 OS OS NNP cord-005453-4057qib7 11942 30 . . . cord-005453-4057qib7 11943 1 Disclosure disclosure NN cord-005453-4057qib7 11943 2 : : : cord-005453-4057qib7 11943 3 Nothing nothing NN cord-005453-4057qib7 11943 4 to to TO cord-005453-4057qib7 11943 5 declare declare VB cord-005453-4057qib7 11943 6 P526 p526 CD cord-005453-4057qib7 11943 7 Abstract Abstract NNP cord-005453-4057qib7 11943 8 already already RB cord-005453-4057qib7 11943 9 published publish VBN cord-005453-4057qib7 11943 10 . . . cord-005453-4057qib7 11944 1 Azacitidine Azacitidine NNP cord-005453-4057qib7 11944 2 ( ( -LRB- cord-005453-4057qib7 11944 3 AZA AZA NNP cord-005453-4057qib7 11944 4 ) ) -RRB- cord-005453-4057qib7 11944 5 for for IN cord-005453-4057qib7 11944 6 prophylaxis prophylaxis NN cord-005453-4057qib7 11944 7 or or CC cord-005453-4057qib7 11944 8 pre pre JJ cord-005453-4057qib7 11944 9 - - JJ cord-005453-4057qib7 11944 10 emptive emptive JJ cord-005453-4057qib7 11944 11 therapy therapy NN cord-005453-4057qib7 11944 12 for for IN cord-005453-4057qib7 11944 13 myeloid myeloid JJ cord-005453-4057qib7 11944 14 neoplasms neoplasm NNS cord-005453-4057qib7 11944 15 after after IN cord-005453-4057qib7 11944 16 allogeneic allogeneic NN cord-005453-4057qib7 11944 17 stem stem NN cord-005453-4057qib7 11944 18 cell cell NN cord-005453-4057qib7 11944 19 transplantation transplantation NN cord-005453-4057qib7 11944 20 whom whom WP cord-005453-4057qib7 11944 21 21 21 CD cord-005453-4057qib7 11944 22 were be VBD cord-005453-4057qib7 11944 23 treated treat VBN cord-005453-4057qib7 11944 24 prophylactically prophylactically RB cord-005453-4057qib7 11944 25 and and CC cord-005453-4057qib7 11944 26 11 11 CD cord-005453-4057qib7 11944 27 preemptively preemptively RB cord-005453-4057qib7 11944 28 . . . cord-005453-4057qib7 11945 1 Median median JJ cord-005453-4057qib7 11945 2 age age NN cord-005453-4057qib7 11945 3 was be VBD cord-005453-4057qib7 11945 4 55 55 CD cord-005453-4057qib7 11945 5 years year NNS cord-005453-4057qib7 11946 1 [ [ -LRB- cord-005453-4057qib7 11946 2 range range NN cord-005453-4057qib7 11946 3 , , , cord-005453-4057qib7 11946 4 15 15 CD cord-005453-4057qib7 11946 5 - - SYM cord-005453-4057qib7 11946 6 69 69 CD cord-005453-4057qib7 11946 7 ] ] -RRB- cord-005453-4057qib7 11946 8 and and CC cord-005453-4057qib7 11946 9 all all DT cord-005453-4057qib7 11946 10 patients patient NNS cord-005453-4057qib7 11946 11 had have VBD cord-005453-4057qib7 11946 12 a a DT cord-005453-4057qib7 11946 13 diagnosis diagnosis NN cord-005453-4057qib7 11946 14 of of IN cord-005453-4057qib7 11946 15 AML AML NNP cord-005453-4057qib7 11946 16 or or CC cord-005453-4057qib7 11946 17 high high JJ cord-005453-4057qib7 11946 18 - - HYPH cord-005453-4057qib7 11946 19 risk risk NN cord-005453-4057qib7 11946 20 MDS MDS NNP cord-005453-4057qib7 11946 21 . . . cord-005453-4057qib7 11947 1 Prophylactic prophylactic JJ cord-005453-4057qib7 11947 2 treatment treatment NN cord-005453-4057qib7 11947 3 consisted consist VBD cord-005453-4057qib7 11947 4 of of IN cord-005453-4057qib7 11947 5 AZA AZA NNP cord-005453-4057qib7 11947 6 32 32 CD cord-005453-4057qib7 11948 1 mg mg NNP cord-005453-4057qib7 11948 2 / / SYM cord-005453-4057qib7 11948 3 m m NNP cord-005453-4057qib7 11948 4 2 2 CD cord-005453-4057qib7 11948 5 for for IN cord-005453-4057qib7 11948 6 5 5 CD cord-005453-4057qib7 11948 7 days day NNS cord-005453-4057qib7 11948 8 in in IN cord-005453-4057qib7 11948 9 cycles cycle NNS cord-005453-4057qib7 11948 10 of of IN cord-005453-4057qib7 11948 11 28 28 CD cord-005453-4057qib7 11948 12 days day NNS cord-005453-4057qib7 11948 13 . . . cord-005453-4057qib7 11949 1 In in IN cord-005453-4057qib7 11949 2 the the DT cord-005453-4057qib7 11949 3 pre pre JJ cord-005453-4057qib7 11949 4 - - JJ cord-005453-4057qib7 11949 5 emptive emptive JJ cord-005453-4057qib7 11949 6 setting setting NN cord-005453-4057qib7 11949 7 , , , cord-005453-4057qib7 11949 8 5 5 CD cord-005453-4057qib7 11949 9 patients patient NNS cord-005453-4057qib7 11949 10 received receive VBD cord-005453-4057qib7 11949 11 75 75 CD cord-005453-4057qib7 11949 12 mg mg NNP cord-005453-4057qib7 11949 13 / / SYM cord-005453-4057qib7 11949 14 m m NNP cord-005453-4057qib7 11949 15 2 2 CD cord-005453-4057qib7 11949 16 for for IN cord-005453-4057qib7 11949 17 7 7 CD cord-005453-4057qib7 11949 18 days day NNS cord-005453-4057qib7 11949 19 per per IN cord-005453-4057qib7 11949 20 cycle cycle NN cord-005453-4057qib7 11949 21 and and CC cord-005453-4057qib7 11949 22 6 6 CD cord-005453-4057qib7 11949 23 patients patient NNS cord-005453-4057qib7 11949 24 75 75 CD cord-005453-4057qib7 11949 25 mg mg NNP cord-005453-4057qib7 11949 26 / / SYM cord-005453-4057qib7 11949 27 m m NN cord-005453-4057qib7 11949 28 2 2 CD cord-005453-4057qib7 11949 29 for for IN cord-005453-4057qib7 11949 30 5 5 CD cord-005453-4057qib7 11949 31 days day NNS cord-005453-4057qib7 11949 32 per per IN cord-005453-4057qib7 11949 33 cycle cycle NN cord-005453-4057qib7 11949 34 . . . cord-005453-4057qib7 11950 1 A a DT cord-005453-4057qib7 11950 2 median median NN cord-005453-4057qib7 11950 3 of of IN cord-005453-4057qib7 11950 4 6 6 CD cord-005453-4057qib7 11950 5 cycles cycle NNS cord-005453-4057qib7 11950 6 [ [ -LRB- cord-005453-4057qib7 11950 7 range range NN cord-005453-4057qib7 11950 8 , , , cord-005453-4057qib7 11950 9 [ [ -LRB- cord-005453-4057qib7 11950 10 1 1 CD cord-005453-4057qib7 11950 11 ] ] -RRB- cord-005453-4057qib7 11950 12 [ [ -LRB- cord-005453-4057qib7 11950 13 2 2 CD cord-005453-4057qib7 11950 14 ] ] -RRB- cord-005453-4057qib7 11950 15 [ [ -LRB- cord-005453-4057qib7 11950 16 3 3 CD cord-005453-4057qib7 11950 17 ] ] -RRB- cord-005453-4057qib7 11950 18 [ [ -LRB- cord-005453-4057qib7 11950 19 4 4 CD cord-005453-4057qib7 11950 20 ] ] -RRB- cord-005453-4057qib7 11950 21 [ [ -LRB- cord-005453-4057qib7 11950 22 5 5 CD cord-005453-4057qib7 11950 23 ] ] -RRB- cord-005453-4057qib7 11950 24 [ [ -LRB- cord-005453-4057qib7 11950 25 6 6 CD cord-005453-4057qib7 11950 26 ] ] -RRB- cord-005453-4057qib7 11950 27 [ [ -LRB- cord-005453-4057qib7 11950 28 7 7 CD cord-005453-4057qib7 11950 29 ] ] -RRB- cord-005453-4057qib7 11950 30 [ [ -LRB- cord-005453-4057qib7 11950 31 8 8 CD cord-005453-4057qib7 11950 32 ] ] -RRB- cord-005453-4057qib7 11950 33 [ [ -LRB- cord-005453-4057qib7 11950 34 9 9 CD cord-005453-4057qib7 11950 35 ] ] -RRB- cord-005453-4057qib7 11950 36 [ [ -LRB- cord-005453-4057qib7 11950 37 10 10 CD cord-005453-4057qib7 11950 38 ] ] -RRB- cord-005453-4057qib7 11950 39 [ [ -LRB- cord-005453-4057qib7 11950 40 11 11 CD cord-005453-4057qib7 11950 41 ] ] -RRB- cord-005453-4057qib7 11950 42 [ [ -LRB- cord-005453-4057qib7 11950 43 12 12 CD cord-005453-4057qib7 11950 44 ] ] -RRB- cord-005453-4057qib7 11950 45 [ [ -LRB- cord-005453-4057qib7 11950 46 13 13 CD cord-005453-4057qib7 11950 47 ] ] -RRB- cord-005453-4057qib7 11950 48 [ [ -LRB- cord-005453-4057qib7 11950 49 14 14 CD cord-005453-4057qib7 11950 50 ] ] -RRB- cord-005453-4057qib7 11950 51 [ [ -LRB- cord-005453-4057qib7 11950 52 15 15 CD cord-005453-4057qib7 11950 53 ] ] -RRB- cord-005453-4057qib7 11950 54 [ [ -LRB- cord-005453-4057qib7 11950 55 16 16 CD cord-005453-4057qib7 11950 56 ] ] -RRB- cord-005453-4057qib7 11950 57 [ [ -LRB- cord-005453-4057qib7 11950 58 17 17 CD cord-005453-4057qib7 11950 59 ] ] -RRB- cord-005453-4057qib7 11950 60 [ [ -LRB- cord-005453-4057qib7 11950 61 18 18 CD cord-005453-4057qib7 11950 62 ] ] -RRB- cord-005453-4057qib7 11950 63 was be VBD cord-005453-4057qib7 11950 64 administered administer VBN cord-005453-4057qib7 11950 65 in in IN cord-005453-4057qib7 11950 66 the the DT cord-005453-4057qib7 11950 67 prophylactic prophylactic JJ cord-005453-4057qib7 11950 68 group group NN cord-005453-4057qib7 11950 69 and and CC cord-005453-4057qib7 11950 70 of of IN cord-005453-4057qib7 11950 71 4 4 CD cord-005453-4057qib7 11950 72 cycles cycle NNS cord-005453-4057qib7 11950 73 [ [ -LRB- cord-005453-4057qib7 11950 74 range range NN cord-005453-4057qib7 11950 75 , , , cord-005453-4057qib7 11950 76 4 4 CD cord-005453-4057qib7 11950 77 - - SYM cord-005453-4057qib7 11950 78 22 22 CD cord-005453-4057qib7 11950 79 ] ] -RRB- cord-005453-4057qib7 11950 80 in in IN cord-005453-4057qib7 11950 81 the the DT cord-005453-4057qib7 11950 82 pre pre JJ cord-005453-4057qib7 11950 83 - - JJ cord-005453-4057qib7 11950 84 emptive emptive JJ cord-005453-4057qib7 11950 85 group group NN cord-005453-4057qib7 11950 86 . . . cord-005453-4057qib7 11951 1 Ten ten CD cord-005453-4057qib7 11951 2 patients patient NNS cord-005453-4057qib7 11951 3 also also RB cord-005453-4057qib7 11951 4 received receive VBD cord-005453-4057qib7 11951 5 at at IN cord-005453-4057qib7 11951 6 least least JJS cord-005453-4057qib7 11951 7 one one CD cord-005453-4057qib7 11951 8 DLI DLI NNP cord-005453-4057qib7 11951 9 after after IN cord-005453-4057qib7 11951 10 the the DT cord-005453-4057qib7 11951 11 third third JJ cord-005453-4057qib7 11951 12 AZA AZA NNP cord-005453-4057qib7 11951 13 cycle cycle NN cord-005453-4057qib7 11951 14 : : : cord-005453-4057qib7 11951 15 8 8 CD cord-005453-4057qib7 11951 16 patients patient NNS cord-005453-4057qib7 11951 17 in in IN cord-005453-4057qib7 11951 18 the the DT cord-005453-4057qib7 11951 19 prophylactic prophylactic JJ cord-005453-4057qib7 11951 20 group group NN cord-005453-4057qib7 11951 21 and and CC cord-005453-4057qib7 11951 22 2 2 CD cord-005453-4057qib7 11951 23 patients patient NNS cord-005453-4057qib7 11951 24 in in IN cord-005453-4057qib7 11951 25 the the DT cord-005453-4057qib7 11951 26 pre pre JJ cord-005453-4057qib7 11951 27 - - JJ cord-005453-4057qib7 11951 28 emptive emptive JJ cord-005453-4057qib7 11951 29 one one CD cord-005453-4057qib7 11951 30 . . . cord-005453-4057qib7 11952 1 Results result NNS cord-005453-4057qib7 11952 2 : : : cord-005453-4057qib7 11953 1 During during IN cord-005453-4057qib7 11953 2 follow follow NN cord-005453-4057qib7 11953 3 - - HYPH cord-005453-4057qib7 11953 4 up up NN cord-005453-4057qib7 11953 5 , , , cord-005453-4057qib7 11953 6 10 10 CD cord-005453-4057qib7 11953 7 patients patient NNS cord-005453-4057qib7 11953 8 had have VBD cord-005453-4057qib7 11953 9 significant significant JJ cord-005453-4057qib7 11953 10 delays delay NNS cord-005453-4057qib7 11953 11 in in IN cord-005453-4057qib7 11953 12 treatment treatment NN cord-005453-4057qib7 11953 13 plan plan NN cord-005453-4057qib7 11953 14 due due JJ cord-005453-4057qib7 11953 15 to to IN cord-005453-4057qib7 11953 16 transitory transitory JJ cord-005453-4057qib7 11953 17 mild mild JJ cord-005453-4057qib7 11953 18 complications complication NNS cord-005453-4057qib7 11953 19 . . . cord-005453-4057qib7 11954 1 However however RB cord-005453-4057qib7 11954 2 , , , cord-005453-4057qib7 11954 3 15 15 CD cord-005453-4057qib7 11954 4 % % NN cord-005453-4057qib7 11954 5 of of IN cord-005453-4057qib7 11954 6 patients patient NNS cord-005453-4057qib7 11954 7 ( ( -LRB- cord-005453-4057qib7 11954 8 n=5 n=5 NNP cord-005453-4057qib7 11954 9 ) ) -RRB- cord-005453-4057qib7 11954 10 presented present VBD cord-005453-4057qib7 11954 11 infectious infectious JJ cord-005453-4057qib7 11954 12 complications complication NNS cord-005453-4057qib7 11954 13 requiring require VBG cord-005453-4057qib7 11954 14 hospitalisation hospitalisation NN cord-005453-4057qib7 11954 15 and and CC cord-005453-4057qib7 11954 16 40 40 CD cord-005453-4057qib7 11954 17 % % NN cord-005453-4057qib7 11954 18 of of IN cord-005453-4057qib7 11954 19 patients patient NNS cord-005453-4057qib7 11954 20 ( ( -LRB- cord-005453-4057qib7 11954 21 n=10 n=10 NNP cord-005453-4057qib7 11954 22 in in IN cord-005453-4057qib7 11954 23 the the DT cord-005453-4057qib7 11954 24 prophylaxis prophylaxis NN cord-005453-4057qib7 11954 25 group group NN cord-005453-4057qib7 11954 26 and and CC cord-005453-4057qib7 11954 27 3 3 CD cord-005453-4057qib7 11954 28 in in IN cord-005453-4057qib7 11954 29 the the DT cord-005453-4057qib7 11954 30 pre pre JJ cord-005453-4057qib7 11954 31 - - JJ cord-005453-4057qib7 11954 32 emptive emptive JJ cord-005453-4057qib7 11954 33 group group NN cord-005453-4057qib7 11954 34 ) ) -RRB- cord-005453-4057qib7 11954 35 presented present VBD cord-005453-4057qib7 11954 36 some some DT cord-005453-4057qib7 11954 37 form form NN cord-005453-4057qib7 11954 38 of of IN cord-005453-4057qib7 11954 39 GvHD GvHD NNP cord-005453-4057qib7 11954 40 . . . cord-005453-4057qib7 11955 1 In in IN cord-005453-4057qib7 11955 2 patients patient NNS cord-005453-4057qib7 11955 3 who who WP cord-005453-4057qib7 11955 4 developed develop VBD cord-005453-4057qib7 11955 5 GvHD GvHD NNP cord-005453-4057qib7 11955 6 , , , cord-005453-4057qib7 11955 7 3 3 CD cord-005453-4057qib7 11955 8 had have VBD cord-005453-4057qib7 11955 9 to to TO cord-005453-4057qib7 11955 10 discontinue discontinue VB cord-005453-4057qib7 11955 11 treatment treatment NN cord-005453-4057qib7 11955 12 ( ( -LRB- cord-005453-4057qib7 11955 13 all all DT cord-005453-4057qib7 11955 14 in in IN cord-005453-4057qib7 11955 15 the the DT cord-005453-4057qib7 11955 16 prophylaxis prophylaxis NN cord-005453-4057qib7 11955 17 group group NN cord-005453-4057qib7 11955 18 ) ) -RRB- cord-005453-4057qib7 11955 19 ; ; : cord-005453-4057qib7 11955 20 also also RB cord-005453-4057qib7 11955 21 8 8 CD cord-005453-4057qib7 11955 22 patients patient NNS cord-005453-4057qib7 11955 23 discontinued discontinue VBD cord-005453-4057qib7 11955 24 treatment treatment NN cord-005453-4057qib7 11955 25 due due IN cord-005453-4057qib7 11955 26 to to IN cord-005453-4057qib7 11955 27 disease disease NN cord-005453-4057qib7 11955 28 progression progression NN cord-005453-4057qib7 11955 29 . . . cord-005453-4057qib7 11956 1 The the DT cord-005453-4057qib7 11956 2 overall overall JJ cord-005453-4057qib7 11956 3 drop drop NN cord-005453-4057qib7 11956 4 - - HYPH cord-005453-4057qib7 11956 5 out out RP cord-005453-4057qib7 11956 6 rate rate NN cord-005453-4057qib7 11956 7 was be VBD cord-005453-4057qib7 11956 8 37.5 37.5 CD cord-005453-4057qib7 11956 9 % % NN cord-005453-4057qib7 11956 10 ( ( -LRB- cord-005453-4057qib7 11956 11 n=12 n=12 NNP cord-005453-4057qib7 11956 12 ) ) -RRB- cord-005453-4057qib7 11956 13 . . . cord-005453-4057qib7 11957 1 Survival survival NN cord-005453-4057qib7 11957 2 was be VBD cord-005453-4057qib7 11957 3 analysed analyse VBN cord-005453-4057qib7 11957 4 from from IN cord-005453-4057qib7 11957 5 initiation initiation NN cord-005453-4057qib7 11957 6 of of IN cord-005453-4057qib7 11957 7 treatment treatment NN cord-005453-4057qib7 11957 8 with with IN cord-005453-4057qib7 11957 9 AZA AZA NNP cord-005453-4057qib7 11957 10 and and CC cord-005453-4057qib7 11957 11 median median JJ cord-005453-4057qib7 11957 12 follow follow NN cord-005453-4057qib7 11957 13 - - HYPH cord-005453-4057qib7 11957 14 up up NN cord-005453-4057qib7 11957 15 was be VBD cord-005453-4057qib7 11957 16 16 16 CD cord-005453-4057qib7 11957 17 months month NNS cord-005453-4057qib7 11957 18 . . . cord-005453-4057qib7 11958 1 One one CD cord-005453-4057qib7 11958 2 - - HYPH cord-005453-4057qib7 11958 3 year year NN cord-005453-4057qib7 11958 4 EFS efs NN cord-005453-4057qib7 11958 5 was be VBD cord-005453-4057qib7 11958 6 95 95 CD cord-005453-4057qib7 11958 7 % % NN cord-005453-4057qib7 11958 8 in in IN cord-005453-4057qib7 11958 9 the the DT cord-005453-4057qib7 11958 10 prophylaxis prophylaxis NN cord-005453-4057qib7 11958 11 group group NN cord-005453-4057qib7 11958 12 , , , cord-005453-4057qib7 11958 13 with with IN cord-005453-4057qib7 11958 14 only only RB cord-005453-4057qib7 11958 15 one one CD cord-005453-4057qib7 11958 16 patient patient NN cord-005453-4057qib7 11958 17 relapsing relapse VBG cord-005453-4057qib7 11958 18 and and CC cord-005453-4057qib7 11958 19 no no DT cord-005453-4057qib7 11958 20 deaths death NNS cord-005453-4057qib7 11958 21 . . . cord-005453-4057qib7 11959 1 In in IN cord-005453-4057qib7 11959 2 the the DT cord-005453-4057qib7 11959 3 pre pre JJ cord-005453-4057qib7 11959 4 - - JJ cord-005453-4057qib7 11959 5 emptive emptive JJ cord-005453-4057qib7 11959 6 group group NN cord-005453-4057qib7 11959 7 , , , cord-005453-4057qib7 11959 8 the the DT cord-005453-4057qib7 11959 9 1-year 1-year CD cord-005453-4057qib7 11959 10 EFS EFS NNP cord-005453-4057qib7 11959 11 was be VBD cord-005453-4057qib7 11959 12 45 45 CD cord-005453-4057qib7 11959 13 % % NN cord-005453-4057qib7 11959 14 and and CC cord-005453-4057qib7 11959 15 the the DT cord-005453-4057qib7 11959 16 median median JJ cord-005453-4057qib7 11959 17 EFS efs NN cord-005453-4057qib7 11959 18 was be VBD cord-005453-4057qib7 11959 19 6 6 CD cord-005453-4057qib7 11959 20 months month NNS cord-005453-4057qib7 11959 21 ; ; : cord-005453-4057qib7 11960 1 1-year 1-year CD cord-005453-4057qib7 11960 2 OS OS NNP cord-005453-4057qib7 11960 3 was be VBD cord-005453-4057qib7 11960 4 70 70 CD cord-005453-4057qib7 11960 5 % % NN cord-005453-4057qib7 11960 6 and and CC cord-005453-4057qib7 11960 7 median median JJ cord-005453-4057qib7 11960 8 OS OS NNP cord-005453-4057qib7 11960 9 was be VBD cord-005453-4057qib7 11960 10 24 24 CD cord-005453-4057qib7 11960 11 months month NNS cord-005453-4057qib7 11960 12 . . . cord-005453-4057qib7 11961 1 Conclusions conclusion NNS cord-005453-4057qib7 11961 2 : : : cord-005453-4057qib7 11962 1 We -PRON- PRP cord-005453-4057qib7 11962 2 conclude conclude VBP cord-005453-4057qib7 11962 3 that that IN cord-005453-4057qib7 11962 4 post post JJ cord-005453-4057qib7 11962 5 - - JJ cord-005453-4057qib7 11962 6 transplant transplant JJ cord-005453-4057qib7 11962 7 AZA AZA NNP cord-005453-4057qib7 11962 8 treatment treatment NN cord-005453-4057qib7 11962 9 is be VBZ cord-005453-4057qib7 11962 10 a a DT cord-005453-4057qib7 11962 11 well well RB cord-005453-4057qib7 11962 12 - - HYPH cord-005453-4057qib7 11962 13 tolerated tolerate VBN cord-005453-4057qib7 11962 14 therapy therapy NN cord-005453-4057qib7 11962 15 , , , cord-005453-4057qib7 11962 16 but but CC cord-005453-4057qib7 11962 17 the the DT cord-005453-4057qib7 11962 18 incidence incidence NN cord-005453-4057qib7 11962 19 of of IN cord-005453-4057qib7 11962 20 side side NN cord-005453-4057qib7 11962 21 effects effect NNS cord-005453-4057qib7 11962 22 remains remain VBZ cord-005453-4057qib7 11962 23 discordant discordant JJ cord-005453-4057qib7 11962 24 in in IN cord-005453-4057qib7 11962 25 the the DT cord-005453-4057qib7 11962 26 literature literature NN cord-005453-4057qib7 11962 27 . . . cord-005453-4057qib7 11963 1 Results result NNS cord-005453-4057qib7 11963 2 in in IN cord-005453-4057qib7 11963 3 the the DT cord-005453-4057qib7 11963 4 prophylaxis prophylaxis NN cord-005453-4057qib7 11963 5 group group NN cord-005453-4057qib7 11963 6 are be VBP cord-005453-4057qib7 11963 7 excellent excellent JJ cord-005453-4057qib7 11963 8 , , , cord-005453-4057qib7 11963 9 but but CC cord-005453-4057qib7 11963 10 patients patient NNS cord-005453-4057qib7 11963 11 with with IN cord-005453-4057qib7 11963 12 positive positive JJ cord-005453-4057qib7 11963 13 minimal minimal JJ cord-005453-4057qib7 11963 14 residual residual JJ cord-005453-4057qib7 11963 15 disease disease NN cord-005453-4057qib7 11963 16 treated treat VBN cord-005453-4057qib7 11963 17 pre pre NNP cord-005453-4057qib7 11963 18 - - NN cord-005453-4057qib7 11963 19 emptively emptively NNP cord-005453-4057qib7 11963 20 had have VBD cord-005453-4057qib7 11963 21 a a DT cord-005453-4057qib7 11963 22 lower low JJR cord-005453-4057qib7 11963 23 outcome outcome NN cord-005453-4057qib7 11963 24 with with IN cord-005453-4057qib7 11963 25 only only JJ cord-005453-4057qib7 11963 26 stabilisation stabilisation NN cord-005453-4057qib7 11963 27 of of IN cord-005453-4057qib7 11963 28 the the DT cord-005453-4057qib7 11963 29 disease disease NN cord-005453-4057qib7 11963 30 . . . cord-005453-4057qib7 11964 1 Randomised randomised JJ cord-005453-4057qib7 11964 2 prospective prospective JJ cord-005453-4057qib7 11964 3 trials trial NNS cord-005453-4057qib7 11964 4 are be VBP cord-005453-4057qib7 11964 5 needed need VBN cord-005453-4057qib7 11964 6 to to TO cord-005453-4057qib7 11964 7 define define VB cord-005453-4057qib7 11964 8 patients patient NNS cord-005453-4057qib7 11964 9 who who WP cord-005453-4057qib7 11964 10 would would MD cord-005453-4057qib7 11964 11 benefit benefit VB cord-005453-4057qib7 11964 12 the the DT cord-005453-4057qib7 11964 13 most most JJS cord-005453-4057qib7 11964 14 from from IN cord-005453-4057qib7 11964 15 this this DT cord-005453-4057qib7 11964 16 treatment treatment NN cord-005453-4057qib7 11964 17 and and CC cord-005453-4057qib7 11964 18 at at IN cord-005453-4057qib7 11964 19 what what WP cord-005453-4057qib7 11964 20 timing timing NN cord-005453-4057qib7 11964 21 , , , cord-005453-4057qib7 11964 22 dosage dosage NN cord-005453-4057qib7 11964 23 and and CC cord-005453-4057qib7 11964 24 duration duration NN cord-005453-4057qib7 11964 25 of of IN cord-005453-4057qib7 11964 26 treatment treatment NN cord-005453-4057qib7 11964 27 . . . cord-005453-4057qib7 11965 1 Disclosure disclosure NN cord-005453-4057qib7 11965 2 : : : cord-005453-4057qib7 11965 3 Nothing nothing NN cord-005453-4057qib7 11965 4 to to TO cord-005453-4057qib7 11965 5 declare declare VB cord-005453-4057qib7 11965 6 . . . cord-005453-4057qib7 11966 1 Abstract Abstract NNP cord-005453-4057qib7 11966 2 already already RB cord-005453-4057qib7 11966 3 published publish VBN cord-005453-4057qib7 11966 4 . . . cord-005453-4057qib7 11967 1 Results result NNS cord-005453-4057qib7 11967 2 : : : cord-005453-4057qib7 11968 1 All all DT cord-005453-4057qib7 11968 2 subjects subject NNS cord-005453-4057qib7 11968 3 experienced experience VBD cord-005453-4057qib7 11968 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 11968 5 engraftment engraftment NN cord-005453-4057qib7 11968 6 at at IN cord-005453-4057qib7 11968 7 a a DT cord-005453-4057qib7 11968 8 median median NN cord-005453-4057qib7 11968 9 of of IN cord-005453-4057qib7 11968 10 17 17 CD cord-005453-4057qib7 11968 11 days day NNS cord-005453-4057qib7 11968 12 ( ( -LRB- cord-005453-4057qib7 11968 13 range range NNP cord-005453-4057qib7 11968 14 14 14 CD cord-005453-4057qib7 11968 15 - - SYM cord-005453-4057qib7 11968 16 20 20 CD cord-005453-4057qib7 11968 17 ) ) -RRB- cord-005453-4057qib7 11968 18 and and CC cord-005453-4057qib7 11968 19 demonstrated demonstrate VBD cord-005453-4057qib7 11968 20 full full JJ cord-005453-4057qib7 11968 21 donor donor NN cord-005453-4057qib7 11968 22 myeloid myeloid NN cord-005453-4057qib7 11968 23 chimerism chimerism NN cord-005453-4057qib7 11968 24 . . . cord-005453-4057qib7 11969 1 M M NNP cord-005453-4057qib7 11969 2 - - HYPH cord-005453-4057qib7 11969 3 MDSC MDSC NNP cord-005453-4057qib7 11969 4 and and CC cord-005453-4057qib7 11969 5 PMN PMN NNP cord-005453-4057qib7 11969 6 - - HYPH cord-005453-4057qib7 11969 7 MDSC MDSC NNP cord-005453-4057qib7 11969 8 recovery recovery NN cord-005453-4057qib7 11969 9 peaked peak VBD cord-005453-4057qib7 11969 10 at at IN cord-005453-4057qib7 11969 11 a a DT cord-005453-4057qib7 11969 12 median median NN cord-005453-4057qib7 11969 13 of of IN cord-005453-4057qib7 11969 14 22 22 CD cord-005453-4057qib7 11969 15 days day NNS cord-005453-4057qib7 11969 16 posttransplant posttransplant NNP cord-005453-4057qib7 11969 17 . . . cord-005453-4057qib7 11970 1 The the DT cord-005453-4057qib7 11970 2 median median JJ cord-005453-4057qib7 11970 3 peak peak NN cord-005453-4057qib7 11970 4 absolute absolute JJ cord-005453-4057qib7 11970 5 M M NNP cord-005453-4057qib7 11970 6 - - HYPH cord-005453-4057qib7 11970 7 MDSC MDSC NNP cord-005453-4057qib7 11970 8 count count NN cord-005453-4057qib7 11970 9 was be VBD cord-005453-4057qib7 11970 10 9,828 9,828 CD cord-005453-4057qib7 11970 11 cell cell NN cord-005453-4057qib7 11970 12 / / SYM cord-005453-4057qib7 11970 13 mL ml NN cord-005453-4057qib7 11970 14 ( ( -LRB- cord-005453-4057qib7 11970 15 range range NN cord-005453-4057qib7 11970 16 9,180 9,180 CD cord-005453-4057qib7 11970 17 - - HYPH cord-005453-4057qib7 11970 18 41,120 41,120 CD cord-005453-4057qib7 11970 19 / / SYM cord-005453-4057qib7 11970 20 mL ml NN cord-005453-4057qib7 11970 21 ) ) -RRB- cord-005453-4057qib7 11970 22 representing represent VBG cord-005453-4057qib7 11970 23 a a DT cord-005453-4057qib7 11970 24 range range NN cord-005453-4057qib7 11970 25 of of IN cord-005453-4057qib7 11970 26 1.5 1.5 CD cord-005453-4057qib7 11970 27 % % NN cord-005453-4057qib7 11970 28 to to IN cord-005453-4057qib7 11970 29 4.8 4.8 CD cord-005453-4057qib7 11970 30 % % NN cord-005453-4057qib7 11970 31 of of IN cord-005453-4057qib7 11970 32 PBMCs pbmc NNS cord-005453-4057qib7 11970 33 . . . cord-005453-4057qib7 11971 1 The the DT cord-005453-4057qib7 11971 2 PMN PMN NNP cord-005453-4057qib7 11971 3 - - HYPH cord-005453-4057qib7 11971 4 MDSC MDSC NNP cord-005453-4057qib7 11971 5 peak peak NN cord-005453-4057qib7 11971 6 was be VBD cord-005453-4057qib7 11971 7 more more RBR cord-005453-4057qib7 11971 8 robust robust JJ cord-005453-4057qib7 11971 9 , , , cord-005453-4057qib7 11971 10 with with IN cord-005453-4057qib7 11971 11 a a DT cord-005453-4057qib7 11971 12 median median JJ cord-005453-4057qib7 11971 13 absolute absolute JJ cord-005453-4057qib7 11971 14 peak peak NN cord-005453-4057qib7 11971 15 of of IN cord-005453-4057qib7 11971 16 103,730 103,730 CD cord-005453-4057qib7 11971 17 cells cell NNS cord-005453-4057qib7 11971 18 / / SYM cord-005453-4057qib7 11971 19 mL ml NN cord-005453-4057qib7 11972 1 ( ( -LRB- cord-005453-4057qib7 11972 2 range range NN cord-005453-4057qib7 11972 3 11,330 11,330 CD cord-005453-4057qib7 11972 4 - - HYPH cord-005453-4057qib7 11972 5 676,800 676,800 CD cord-005453-4057qib7 11972 6 / / SYM cord-005453-4057qib7 11972 7 mL ml NN cord-005453-4057qib7 11972 8 ) ) -RRB- cord-005453-4057qib7 11972 9 representing represent VBG cord-005453-4057qib7 11972 10 a a DT cord-005453-4057qib7 11972 11 median median NN cord-005453-4057qib7 11972 12 of of IN cord-005453-4057qib7 11972 13 25.3 25.3 CD cord-005453-4057qib7 11972 14 % % NN cord-005453-4057qib7 11972 15 of of IN cord-005453-4057qib7 11972 16 PBMCs pbmc NNS cord-005453-4057qib7 11972 17 ( ( -LRB- cord-005453-4057qib7 11972 18 range range VB cord-005453-4057qib7 11972 19 10 10 CD cord-005453-4057qib7 11972 20 . . . cord-005453-4057qib7 11973 1 3 3 LS cord-005453-4057qib7 11973 2 - - SYM cord-005453-4057qib7 11973 3 44.2 44.2 CD cord-005453-4057qib7 11973 4 % % NN cord-005453-4057qib7 11973 5 ) ) -RRB- cord-005453-4057qib7 11973 6 . . . cord-005453-4057qib7 11974 1 Of of IN cord-005453-4057qib7 11974 2 note note NN cord-005453-4057qib7 11974 3 , , , cord-005453-4057qib7 11974 4 the the DT cord-005453-4057qib7 11974 5 one one CD cord-005453-4057qib7 11974 6 patient patient NN cord-005453-4057qib7 11974 7 who who WP cord-005453-4057qib7 11974 8 developed develop VBD cord-005453-4057qib7 11974 9 severe severe JJ cord-005453-4057qib7 11974 10 , , , cord-005453-4057qib7 11974 11 life life NN cord-005453-4057qib7 11974 12 - - HYPH cord-005453-4057qib7 11974 13 threatening threaten VBG cord-005453-4057qib7 11974 14 GVHD GVHD NNP cord-005453-4057qib7 11974 15 had have VBD cord-005453-4057qib7 11974 16 the the DT cord-005453-4057qib7 11974 17 lowest low JJS cord-005453-4057qib7 11974 18 absolute absolute JJ cord-005453-4057qib7 11974 19 and and CC cord-005453-4057qib7 11974 20 relative relative JJ cord-005453-4057qib7 11974 21 PMN PMN NNP cord-005453-4057qib7 11974 22 - - HYPH cord-005453-4057qib7 11974 23 MDSC MDSC NNP cord-005453-4057qib7 11974 24 recovery recovery NN cord-005453-4057qib7 11974 25 ( ( -LRB- cord-005453-4057qib7 11974 26 11,330 11,330 CD cord-005453-4057qib7 11974 27 cells cell NNS cord-005453-4057qib7 11974 28 / / SYM cord-005453-4057qib7 11974 29 mL ml NN cord-005453-4057qib7 11974 30 and and CC cord-005453-4057qib7 11974 31 10.3 10.3 CD cord-005453-4057qib7 11974 32 % % NN cord-005453-4057qib7 11974 33 of of IN cord-005453-4057qib7 11974 34 total total JJ cord-005453-4057qib7 11974 35 PBMCs pbmc NNS cord-005453-4057qib7 11974 36 ) ) -RRB- cord-005453-4057qib7 11974 37 . . . cord-005453-4057qib7 11975 1 Recovery recovery NN cord-005453-4057qib7 11975 2 of of IN cord-005453-4057qib7 11975 3 M M NNP cord-005453-4057qib7 11975 4 - - HYPH cord-005453-4057qib7 11975 5 and and CC cord-005453-4057qib7 11975 6 PMN PMN NNP cord-005453-4057qib7 11975 7 - - HYPH cord-005453-4057qib7 11975 8 MDSCs MDSCs NNP cord-005453-4057qib7 11975 9 occurred occur VBD cord-005453-4057qib7 11975 10 at at IN cord-005453-4057qib7 11975 11 a a DT cord-005453-4057qib7 11975 12 similar similar JJ cord-005453-4057qib7 11975 13 tempo tempo NN cord-005453-4057qib7 11975 14 and and CC cord-005453-4057qib7 11975 15 magnitude magnitude NN cord-005453-4057qib7 11975 16 in in IN cord-005453-4057qib7 11975 17 two two CD cord-005453-4057qib7 11975 18 recipients recipient NNS cord-005453-4057qib7 11975 19 of of IN cord-005453-4057qib7 11975 20 standard standard JJ cord-005453-4057qib7 11975 21 GVHD GVHD NNP cord-005453-4057qib7 11975 22 prophylaxis prophylaxis NN cord-005453-4057qib7 11975 23 ( ( -LRB- cord-005453-4057qib7 11975 24 tacrolimus tacrolimus NNP cord-005453-4057qib7 11975 25 / / SYM cord-005453-4057qib7 11975 26 methotrexate methotrexate NNP cord-005453-4057qib7 11975 27 ) ) -RRB- cord-005453-4057qib7 11975 28 . . . cord-005453-4057qib7 11976 1 However however RB cord-005453-4057qib7 11976 2 , , , cord-005453-4057qib7 11976 3 while while IN cord-005453-4057qib7 11976 4 MDSCs mdsc NNS cord-005453-4057qib7 11976 5 isolated isolate VBN cord-005453-4057qib7 11976 6 from from IN cord-005453-4057qib7 11976 7 PTCy PTCy NNS cord-005453-4057qib7 11976 8 recipients recipient NNS cord-005453-4057qib7 11976 9 exhibited exhibit VBD cord-005453-4057qib7 11976 10 clear clear JJ cord-005453-4057qib7 11976 11 T t NN cord-005453-4057qib7 11976 12 - - HYPH cord-005453-4057qib7 11976 13 cell cell NN cord-005453-4057qib7 11976 14 suppressive suppressive JJ cord-005453-4057qib7 11976 15 capacity capacity NN cord-005453-4057qib7 11976 16 , , , cord-005453-4057qib7 11976 17 those those DT cord-005453-4057qib7 11976 18 from from IN cord-005453-4057qib7 11976 19 the the DT cord-005453-4057qib7 11976 20 comparison comparison NN cord-005453-4057qib7 11976 21 patients patient NNS cord-005453-4057qib7 11976 22 did do VBD cord-005453-4057qib7 11976 23 not not RB cord-005453-4057qib7 11976 24 ( ( -LRB- cord-005453-4057qib7 11976 25 see see VB cord-005453-4057qib7 11976 26 Figure figure NN cord-005453-4057qib7 11976 27 ) ) -RRB- cord-005453-4057qib7 11976 28 . . . cord-005453-4057qib7 11977 1 Conclusions conclusion NNS cord-005453-4057qib7 11977 2 : : : cord-005453-4057qib7 11978 1 MDSCs mdsc NNS cord-005453-4057qib7 11978 2 recover recover VB cord-005453-4057qib7 11978 3 rapidly rapidly RB cord-005453-4057qib7 11978 4 and and CC cord-005453-4057qib7 11978 5 robustly robustly RB cord-005453-4057qib7 11978 6 after after IN cord-005453-4057qib7 11978 7 alloHCT allohct XX cord-005453-4057qib7 11978 8 using use VBG cord-005453-4057qib7 11978 9 PTCy PTCy NNS cord-005453-4057qib7 11978 10 as as IN cord-005453-4057qib7 11978 11 GVHD GVHD NNP cord-005453-4057qib7 11978 12 prophylaxis prophylaxis NN cord-005453-4057qib7 11978 13 , , , cord-005453-4057qib7 11978 14 and and CC cord-005453-4057qib7 11978 15 may may MD cord-005453-4057qib7 11978 16 play play VB cord-005453-4057qib7 11978 17 a a DT cord-005453-4057qib7 11978 18 role role NN cord-005453-4057qib7 11978 19 in in IN cord-005453-4057qib7 11978 20 mitigating mitigate VBG cord-005453-4057qib7 11978 21 GVHD GVHD NNP cord-005453-4057qib7 11978 22 risk risk NN cord-005453-4057qib7 11978 23 by by IN cord-005453-4057qib7 11978 24 mediating mediate VBG cord-005453-4057qib7 11978 25 T T NNP cord-005453-4057qib7 11978 26 - - HYPH cord-005453-4057qib7 11978 27 cell cell NN cord-005453-4057qib7 11978 28 suppression suppression NN cord-005453-4057qib7 11978 29 . . . cord-005453-4057qib7 11979 1 This this DT cord-005453-4057qib7 11979 2 may may MD cord-005453-4057qib7 11979 3 be be VB cord-005453-4057qib7 11979 4 a a DT cord-005453-4057qib7 11979 5 mechanism mechanism NN cord-005453-4057qib7 11979 6 by by IN cord-005453-4057qib7 11979 7 which which WDT cord-005453-4057qib7 11979 8 PTCy PTCy VBZ cord-005453-4057qib7 11979 9 results result NNS cord-005453-4057qib7 11979 10 in in IN cord-005453-4057qib7 11979 11 donor donor NN cord-005453-4057qib7 11979 12 - - HYPH cord-005453-4057qib7 11979 13 recipient recipient NN cord-005453-4057qib7 11979 14 tolerance tolerance NN cord-005453-4057qib7 11979 15 . . . cord-005453-4057qib7 11980 1 Background background NN cord-005453-4057qib7 11980 2 : : : cord-005453-4057qib7 11981 1 High high JJ cord-005453-4057qib7 11981 2 dose dose NN cord-005453-4057qib7 11981 3 chemotherapy chemotherapy NN cord-005453-4057qib7 11981 4 followed follow VBN cord-005453-4057qib7 11981 5 by by IN cord-005453-4057qib7 11981 6 autologous autologous JJ cord-005453-4057qib7 11981 7 stem stem NN cord-005453-4057qib7 11981 8 cell cell NN cord-005453-4057qib7 11981 9 transplantation transplantation NN cord-005453-4057qib7 11981 10 ( ( -LRB- cord-005453-4057qib7 11981 11 ASCT ASCT NNP cord-005453-4057qib7 11981 12 ) ) -RRB- cord-005453-4057qib7 11981 13 offers offer VBZ cord-005453-4057qib7 11981 14 a a DT cord-005453-4057qib7 11981 15 cure cure NN cord-005453-4057qib7 11981 16 in in IN cord-005453-4057qib7 11981 17 the the DT cord-005453-4057qib7 11981 18 upfront upfront NN cord-005453-4057qib7 11981 19 and and CC cord-005453-4057qib7 11981 20 relapsed relapse VBD cord-005453-4057qib7 11981 21 setting setting NN cord-005453-4057qib7 11981 22 in in IN cord-005453-4057qib7 11981 23 both both DT cord-005453-4057qib7 11981 24 Hodgkin Hodgkin NNP cord-005453-4057qib7 11981 25 ( ( -LRB- cord-005453-4057qib7 11981 26 HL HL NNP cord-005453-4057qib7 11981 27 ) ) -RRB- cord-005453-4057qib7 11981 28 and and CC cord-005453-4057qib7 11981 29 non non JJ cord-005453-4057qib7 11981 30 - - JJ cord-005453-4057qib7 11981 31 Hodgkin hodgkin JJ cord-005453-4057qib7 11981 32 lymphoma lymphoma NN cord-005453-4057qib7 11981 33 ( ( -LRB- cord-005453-4057qib7 11981 34 NHL NHL NNP cord-005453-4057qib7 11981 35 ) ) -RRB- cord-005453-4057qib7 11981 36 . . . cord-005453-4057qib7 11982 1 ASCT ASCT NNP cord-005453-4057qib7 11982 2 also also RB cord-005453-4057qib7 11982 3 remains remain VBZ cord-005453-4057qib7 11982 4 standard standard NN cord-005453-4057qib7 11982 5 of of IN cord-005453-4057qib7 11982 6 care care NN cord-005453-4057qib7 11982 7 in in IN cord-005453-4057qib7 11982 8 previously previously RB cord-005453-4057qib7 11982 9 untreated untreated JJ cord-005453-4057qib7 11982 10 multiple multiple JJ cord-005453-4057qib7 11982 11 myeloma myeloma NN cord-005453-4057qib7 11982 12 ( ( -LRB- cord-005453-4057qib7 11982 13 MM MM NNP cord-005453-4057qib7 11982 14 ) ) -RRB- cord-005453-4057qib7 11982 15 patients patient NNS cord-005453-4057qib7 11982 16 after after IN cord-005453-4057qib7 11982 17 induction induction NN cord-005453-4057qib7 11982 18 therapy therapy NN cord-005453-4057qib7 11982 19 , , , cord-005453-4057qib7 11982 20 if if IN cord-005453-4057qib7 11982 21 eligible eligible JJ cord-005453-4057qib7 11982 22 . . . cord-005453-4057qib7 11983 1 The the DT cord-005453-4057qib7 11983 2 availability availability NN cord-005453-4057qib7 11983 3 of of IN cord-005453-4057qib7 11983 4 new new JJ cord-005453-4057qib7 11983 5 cellular cellular JJ cord-005453-4057qib7 11983 6 or or CC cord-005453-4057qib7 11983 7 other other JJ cord-005453-4057qib7 11983 8 immune immune JJ cord-005453-4057qib7 11983 9 therapies therapy NNS cord-005453-4057qib7 11983 10 that that WDT cord-005453-4057qib7 11983 11 can can MD cord-005453-4057qib7 11983 12 be be VB cord-005453-4057qib7 11983 13 used use VBN cord-005453-4057qib7 11983 14 after after IN cord-005453-4057qib7 11983 15 ASCT ASCT NNP cord-005453-4057qib7 11983 16 underscores underscore VBZ cord-005453-4057qib7 11983 17 the the DT cord-005453-4057qib7 11983 18 potential potential JJ cord-005453-4057qib7 11983 19 importance importance NN cord-005453-4057qib7 11983 20 of of IN cord-005453-4057qib7 11983 21 monitoring monitor VBG cord-005453-4057qib7 11983 22 immune immune JJ cord-005453-4057qib7 11983 23 reconstitution reconstitution NN cord-005453-4057qib7 11983 24 after after IN cord-005453-4057qib7 11983 25 ASCT ASCT NNP cord-005453-4057qib7 11983 26 . . . cord-005453-4057qib7 11984 1 Methods method NNS cord-005453-4057qib7 11984 2 : : : cord-005453-4057qib7 11985 1 Immune immune JJ cord-005453-4057qib7 11985 2 reconstitution reconstitution NN cord-005453-4057qib7 11985 3 panels panel NNS cord-005453-4057qib7 11985 4 ( ( -LRB- cord-005453-4057qib7 11985 5 IRP IRP NNP cord-005453-4057qib7 11985 6 ) ) -RRB- cord-005453-4057qib7 11985 7 were be VBD cord-005453-4057qib7 11985 8 evaluated evaluate VBN cord-005453-4057qib7 11985 9 retrospectively retrospectively RB cord-005453-4057qib7 11985 10 in in IN cord-005453-4057qib7 11985 11 all all DT cord-005453-4057qib7 11985 12 lymphoma lymphoma NN cord-005453-4057qib7 11985 13 and and CC cord-005453-4057qib7 11985 14 MM MM NNP cord-005453-4057qib7 11985 15 patients patient NNS cord-005453-4057qib7 11985 16 over over IN cord-005453-4057qib7 11985 17 a a DT cord-005453-4057qib7 11985 18 5-year 5-year CD cord-005453-4057qib7 11985 19 span span NN cord-005453-4057qib7 11985 20 ( ( -LRB- cord-005453-4057qib7 11985 21 2012 2012 CD cord-005453-4057qib7 11985 22 - - SYM cord-005453-4057qib7 11985 23 2017 2017 CD cord-005453-4057qib7 11985 24 ) ) -RRB- cord-005453-4057qib7 11985 25 whom whom WP cord-005453-4057qib7 11985 26 underwent undergo VBD cord-005453-4057qib7 11985 27 ASCT ASCT NNP cord-005453-4057qib7 11985 28 at at IN cord-005453-4057qib7 11985 29 our -PRON- PRP$ cord-005453-4057qib7 11985 30 institution institution NN cord-005453-4057qib7 11985 31 . . . cord-005453-4057qib7 11986 1 Patients patient NNS cord-005453-4057qib7 11986 2 were be VBD cord-005453-4057qib7 11986 3 included include VBN cord-005453-4057qib7 11986 4 if if IN cord-005453-4057qib7 11986 5 they -PRON- PRP cord-005453-4057qib7 11986 6 had have VBD cord-005453-4057qib7 11986 7 a a DT cord-005453-4057qib7 11986 8 pre pre JJ cord-005453-4057qib7 11986 9 - - JJ cord-005453-4057qib7 11986 10 ASCT ASCT NNP cord-005453-4057qib7 11986 11 measured measure VBN cord-005453-4057qib7 11986 12 within within IN cord-005453-4057qib7 11986 13 30 30 CD cord-005453-4057qib7 11986 14 days day NNS cord-005453-4057qib7 11986 15 of of IN cord-005453-4057qib7 11986 16 ASCT ASCT NNP cord-005453-4057qib7 11986 17 and and CC cord-005453-4057qib7 11986 18 two two CD cord-005453-4057qib7 11986 19 other other JJ cord-005453-4057qib7 11986 20 IRP IRP NNP cord-005453-4057qib7 11986 21 at at IN cord-005453-4057qib7 11986 22 any any DT cord-005453-4057qib7 11986 23 of of IN cord-005453-4057qib7 11986 24 the the DT cord-005453-4057qib7 11986 25 following follow VBG cord-005453-4057qib7 11986 26 timepoints timepoint NNS cord-005453-4057qib7 11986 27 ( ( -LRB- cord-005453-4057qib7 11986 28 1 1 CD cord-005453-4057qib7 11986 29 ) ) -RRB- cord-005453-4057qib7 11986 30 day day NN cord-005453-4057qib7 11986 31 30 30 CD cord-005453-4057qib7 11986 32 - - SYM cord-005453-4057qib7 11986 33 45 45 CD cord-005453-4057qib7 11986 34 , , , cord-005453-4057qib7 11986 35 ( ( -LRB- cord-005453-4057qib7 11986 36 2 2 LS cord-005453-4057qib7 11986 37 ) ) -RRB- cord-005453-4057qib7 11986 38 day day NN cord-005453-4057qib7 11986 39 60 60 CD cord-005453-4057qib7 11986 40 - - SYM cord-005453-4057qib7 11986 41 90 90 CD cord-005453-4057qib7 11986 42 , , , cord-005453-4057qib7 11986 43 and and CC cord-005453-4057qib7 11986 44 ( ( -LRB- cord-005453-4057qib7 11986 45 3 3 LS cord-005453-4057qib7 11986 46 ) ) -RRB- cord-005453-4057qib7 11986 47 at at IN cord-005453-4057qib7 11986 48 1-year 1-year CD cord-005453-4057qib7 11986 49 post post JJ cord-005453-4057qib7 11986 50 - - JJ cord-005453-4057qib7 11986 51 ASCT asct JJ cord-005453-4057qib7 11986 52 . . . cord-005453-4057qib7 11987 1 Patients patient NNS cord-005453-4057qib7 11987 2 in in IN cord-005453-4057qib7 11987 3 the the DT cord-005453-4057qib7 11987 4 lymphoma lymphoma NN cord-005453-4057qib7 11987 5 cohort cohort NN cord-005453-4057qib7 11987 6 had have VBD cord-005453-4057qib7 11987 7 their -PRON- PRP$ cord-005453-4057qib7 11987 8 IRP IRP NNP cord-005453-4057qib7 11987 9 excluded exclude VBN cord-005453-4057qib7 11987 10 if if IN cord-005453-4057qib7 11987 11 they -PRON- PRP cord-005453-4057qib7 11987 12 had have VBD cord-005453-4057qib7 11987 13 additional additional JJ cord-005453-4057qib7 11987 14 treatment treatment NN cord-005453-4057qib7 11987 15 within within IN cord-005453-4057qib7 11987 16 the the DT cord-005453-4057qib7 11987 17 first first JJ cord-005453-4057qib7 11987 18 year year NN cord-005453-4057qib7 11987 19 post post NN cord-005453-4057qib7 11987 20 - - JJ cord-005453-4057qib7 11987 21 ASCT asct JJ cord-005453-4057qib7 11987 22 ( ( -LRB- cord-005453-4057qib7 11987 23 other other JJ cord-005453-4057qib7 11987 24 than than IN cord-005453-4057qib7 11987 25 maintenance maintenance NN cord-005453-4057qib7 11987 26 rituximab rituximab NNP cord-005453-4057qib7 11987 27 ) ) -RRB- cord-005453-4057qib7 11987 28 . . . cord-005453-4057qib7 11988 1 Mononuclear Mononuclear NNP cord-005453-4057qib7 11988 2 cells cell NNS cord-005453-4057qib7 11988 3 from from IN cord-005453-4057qib7 11988 4 peripheral peripheral JJ cord-005453-4057qib7 11988 5 blood blood NN cord-005453-4057qib7 11988 6 were be VBD cord-005453-4057qib7 11988 7 analyzed analyze VBN cord-005453-4057qib7 11988 8 by by IN cord-005453-4057qib7 11988 9 flow flow NN cord-005453-4057qib7 11988 10 cytometry cytometry NN cord-005453-4057qib7 11988 11 for for IN cord-005453-4057qib7 11988 12 assessment assessment NN cord-005453-4057qib7 11988 13 of of IN cord-005453-4057qib7 11988 14 lymphocyte lymphocyte NN cord-005453-4057qib7 11988 15 phenotype phenotype NN cord-005453-4057qib7 11988 16 and and CC cord-005453-4057qib7 11988 17 numbers number NNS cord-005453-4057qib7 11988 18 . . . cord-005453-4057qib7 11989 1 Absolute absolute JJ cord-005453-4057qib7 11989 2 values value NNS cord-005453-4057qib7 11989 3 were be VBD cord-005453-4057qib7 11989 4 compared compare VBN cord-005453-4057qib7 11989 5 using use VBG cord-005453-4057qib7 11989 6 the the DT cord-005453-4057qib7 11989 7 Mann Mann NNP cord-005453-4057qib7 11989 8 - - HYPH cord-005453-4057qib7 11989 9 Whitney Whitney NNP cord-005453-4057qib7 11989 10 U U NNP cord-005453-4057qib7 11989 11 test test NN cord-005453-4057qib7 11989 12 . . . cord-005453-4057qib7 11990 1 Results result NNS cord-005453-4057qib7 11990 2 : : : cord-005453-4057qib7 11991 1 The the DT cord-005453-4057qib7 11991 2 data datum NNS cord-005453-4057qib7 11991 3 on on IN cord-005453-4057qib7 11991 4 78 78 CD cord-005453-4057qib7 11991 5 patients patient NNS cord-005453-4057qib7 11991 6 were be VBD cord-005453-4057qib7 11991 7 available available JJ cord-005453-4057qib7 11991 8 for for IN cord-005453-4057qib7 11991 9 analysis analysis NN cord-005453-4057qib7 11991 10 ( ( -LRB- cord-005453-4057qib7 11991 11 50 50 CD cord-005453-4057qib7 11991 12 MM MM NNP cord-005453-4057qib7 11991 13 , , , cord-005453-4057qib7 11991 14 24 24 CD cord-005453-4057qib7 11991 15 NHL NHL NNP cord-005453-4057qib7 11991 16 , , , cord-005453-4057qib7 11991 17 4 4 CD cord-005453-4057qib7 11991 18 HL HL NNP cord-005453-4057qib7 11991 19 ) ) -RRB- cord-005453-4057qib7 11991 20 . . . cord-005453-4057qib7 11992 1 All all DT cord-005453-4057qib7 11992 2 lymphoma lymphoma NN cord-005453-4057qib7 11992 3 patients patient NNS cord-005453-4057qib7 11992 4 were be VBD cord-005453-4057qib7 11992 5 conditioned condition VBN cord-005453-4057qib7 11992 6 with with IN cord-005453-4057qib7 11992 7 BEAM BEAM NNP cord-005453-4057qib7 11992 8 . . . cord-005453-4057qib7 11993 1 All all DT cord-005453-4057qib7 11993 2 MM MM NNP cord-005453-4057qib7 11993 3 patients patient NNS cord-005453-4057qib7 11993 4 were be VBD cord-005453-4057qib7 11993 5 conditioned condition VBN cord-005453-4057qib7 11993 6 with with IN cord-005453-4057qib7 11993 7 a a DT cord-005453-4057qib7 11993 8 standard standard JJ cord-005453-4057qib7 11993 9 high high JJ cord-005453-4057qib7 11993 10 dose dose NN cord-005453-4057qib7 11993 11 melphalan melphalan NNP cord-005453-4057qib7 11993 12 regimen regimen NN cord-005453-4057qib7 11993 13 . . . cord-005453-4057qib7 11994 1 The the DT cord-005453-4057qib7 11994 2 median median JJ cord-005453-4057qib7 11994 3 pre pre JJ cord-005453-4057qib7 11994 4 - - JJ cord-005453-4057qib7 11994 5 ASCT asct JJ cord-005453-4057qib7 11994 6 absolute absolute JJ cord-005453-4057qib7 11994 7 CD3 CD3 NNP cord-005453-4057qib7 11994 8 counts count VBZ cord-005453-4057qib7 11994 9 in in IN cord-005453-4057qib7 11994 10 the the DT cord-005453-4057qib7 11994 11 lymphoma lymphoma NN cord-005453-4057qib7 11994 12 cohort cohort NN cord-005453-4057qib7 11994 13 were be VBD cord-005453-4057qib7 11994 14 significantly significantly RB cord-005453-4057qib7 11994 15 lower low JJR cord-005453-4057qib7 11994 16 than than IN cord-005453-4057qib7 11994 17 the the DT cord-005453-4057qib7 11994 18 MM MM NNP cord-005453-4057qib7 11994 19 cohort cohort NN cord-005453-4057qib7 11994 20 at at IN cord-005453-4057qib7 11994 21 1709 1709 CD cord-005453-4057qib7 11994 22 cells cell NNS cord-005453-4057qib7 11995 1 / / NFP cord-005453-4057qib7 11996 1 μL μL . cord-005453-4057qib7 11997 1 vs vs IN cord-005453-4057qib7 11997 2 3309 3309 CD cord-005453-4057qib7 11997 3 cells/ cells/ CD cord-005453-4057qib7 11998 1 μL μL NNP cord-005453-4057qib7 11998 2 , , , cord-005453-4057qib7 11999 1 respectively respectively RB cord-005453-4057qib7 11999 2 ( ( -LRB- cord-005453-4057qib7 11999 3 P=0.049 P=0.049 NNP cord-005453-4057qib7 11999 4 ) ) -RRB- cord-005453-4057qib7 11999 5 . . . cord-005453-4057qib7 12000 1 However however RB cord-005453-4057qib7 12000 2 , , , cord-005453-4057qib7 12000 3 the the DT cord-005453-4057qib7 12000 4 MM MM NNP cord-005453-4057qib7 12000 5 cohort cohort NN cord-005453-4057qib7 12000 6 exhibited exhibit VBD cord-005453-4057qib7 12000 7 a a DT cord-005453-4057qib7 12000 8 greater great JJR cord-005453-4057qib7 12000 9 percent percent NN cord-005453-4057qib7 12000 10 reduction reduction NN cord-005453-4057qib7 12000 11 in in IN cord-005453-4057qib7 12000 12 CD3 CD3 NNP cord-005453-4057qib7 12000 13 cells cell NNS cord-005453-4057qib7 12000 14 on on IN cord-005453-4057qib7 12000 15 day day NN cord-005453-4057qib7 12000 16 30 30 CD cord-005453-4057qib7 12000 17 at at IN cord-005453-4057qib7 12000 18 85.3 85.3 CD cord-005453-4057qib7 12000 19 % % NN cord-005453-4057qib7 12000 20 vs vs IN cord-005453-4057qib7 12000 21 63.5 63.5 CD cord-005453-4057qib7 12000 22 % % NN cord-005453-4057qib7 12000 23 , , , cord-005453-4057qib7 12000 24 respectively respectively RB cord-005453-4057qib7 12000 25 which which WDT cord-005453-4057qib7 12000 26 continued continue VBD cord-005453-4057qib7 12000 27 through through IN cord-005453-4057qib7 12000 28 day day NN cord-005453-4057qib7 12000 29 365 365 CD cord-005453-4057qib7 12000 30 at at IN cord-005453-4057qib7 12000 31 79.8 79.8 CD cord-005453-4057qib7 12000 32 % % NN cord-005453-4057qib7 12000 33 vs vs IN cord-005453-4057qib7 12000 34 70.3 70.3 CD cord-005453-4057qib7 12000 35 % % NN cord-005453-4057qib7 12000 36 , , , cord-005453-4057qib7 12000 37 respectively respectively RB cord-005453-4057qib7 12000 38 . . . cord-005453-4057qib7 12001 1 This this DT cord-005453-4057qib7 12001 2 led lead VBD cord-005453-4057qib7 12001 3 to to IN cord-005453-4057qib7 12001 4 nonsignificant nonsignificant JJ cord-005453-4057qib7 12001 5 changes change NNS cord-005453-4057qib7 12001 6 in in IN cord-005453-4057qib7 12001 7 absolute absolute JJ cord-005453-4057qib7 12001 8 CD3 CD3 NNP cord-005453-4057qib7 12001 9 count count NN cord-005453-4057qib7 12001 10 by by IN cord-005453-4057qib7 12001 11 day day NN cord-005453-4057qib7 12001 12 365 365 CD cord-005453-4057qib7 12001 13 at at IN cord-005453-4057qib7 12001 14 667 667 CD cord-005453-4057qib7 12001 15 cells/ cells/ CD cord-005453-4057qib7 12002 1 μL μL . cord-005453-4057qib7 12003 1 vs vs IN cord-005453-4057qib7 12003 2 507 507 CD cord-005453-4057qib7 12003 3 cells cell NNS cord-005453-4057qib7 12003 4 / / SYM cord-005453-4057qib7 12003 5 μL μl NN cord-005453-4057qib7 12003 6 , , , cord-005453-4057qib7 12003 7 respectively respectively RB cord-005453-4057qib7 12003 8 ( ( -LRB- cord-005453-4057qib7 12003 9 P=0.39 p=0.39 NN cord-005453-4057qib7 12003 10 ) ) -RRB- cord-005453-4057qib7 12003 11 ( ( -LRB- cord-005453-4057qib7 12003 12 figure figure NN cord-005453-4057qib7 12003 13 1 1 CD cord-005453-4057qib7 12003 14 ) ) -RRB- cord-005453-4057qib7 12003 15 . . . cord-005453-4057qib7 12004 1 The the DT cord-005453-4057qib7 12004 2 median median JJ cord-005453-4057qib7 12004 3 absolute absolute JJ cord-005453-4057qib7 12004 4 CD4 CD4 NNP cord-005453-4057qib7 12004 5 count count NN cord-005453-4057qib7 12004 6 pre pre JJ cord-005453-4057qib7 12004 7 - - JJ cord-005453-4057qib7 12004 8 ASCT ASCT NNP cord-005453-4057qib7 12004 9 for for IN cord-005453-4057qib7 12004 10 MM MM NNP cord-005453-4057qib7 12004 11 and and CC cord-005453-4057qib7 12004 12 lymphoma lymphoma NN cord-005453-4057qib7 12004 13 cohorts cohort NNS cord-005453-4057qib7 12004 14 were be VBD cord-005453-4057qib7 12004 15 2101 2101 CD cord-005453-4057qib7 12004 16 cells/ cells/ CD cord-005453-4057qib7 12005 1 μL μL NNP cord-005453-4057qib7 12005 2 and and CC cord-005453-4057qib7 12005 3 863 863 CD cord-005453-4057qib7 12005 4 cells/ cells/ CD cord-005453-4057qib7 12006 1 μL μL NNP cord-005453-4057qib7 12006 2 , , , cord-005453-4057qib7 12007 1 respectively respectively RB cord-005453-4057qib7 12007 2 ( ( -LRB- cord-005453-4057qib7 12007 3 P=0.007 p=0.007 NN cord-005453-4057qib7 12007 4 ) ) -RRB- cord-005453-4057qib7 12007 5 . . . cord-005453-4057qib7 12008 1 Similarly similarly RB cord-005453-4057qib7 12008 2 , , , cord-005453-4057qib7 12008 3 a a DT cord-005453-4057qib7 12008 4 greater great JJR cord-005453-4057qib7 12008 5 percent percent NN cord-005453-4057qib7 12008 6 reduction reduction NN cord-005453-4057qib7 12008 7 in in IN cord-005453-4057qib7 12008 8 CD4 CD4 NNP cord-005453-4057qib7 12008 9 cells cell NNS cord-005453-4057qib7 12008 10 led lead VBD cord-005453-4057qib7 12008 11 to to IN cord-005453-4057qib7 12008 12 comparable comparable JJ cord-005453-4057qib7 12008 13 absolute absolute JJ cord-005453-4057qib7 12008 14 counts count NNS cord-005453-4057qib7 12008 15 on on IN cord-005453-4057qib7 12008 16 day day NN cord-005453-4057qib7 12008 17 365 365 CD cord-005453-4057qib7 12008 18 at at IN cord-005453-4057qib7 12008 19 310 310 CD cord-005453-4057qib7 12008 20 cells/ cells/ CD cord-005453-4057qib7 12009 1 μL μL . cord-005453-4057qib7 12010 1 vs vs IN cord-005453-4057qib7 12010 2 298 298 CD cord-005453-4057qib7 12010 3 cells cell NNS cord-005453-4057qib7 12010 4 / / SYM cord-005453-4057qib7 12010 5 μL μl NN cord-005453-4057qib7 12010 6 , , , cord-005453-4057qib7 12010 7 respectively respectively RB cord-005453-4057qib7 12010 8 ( ( -LRB- cord-005453-4057qib7 12010 9 P=0.322 P=0.322 NNP cord-005453-4057qib7 12010 10 ) ) -RRB- cord-005453-4057qib7 12010 11 . . . cord-005453-4057qib7 12011 1 The the DT cord-005453-4057qib7 12011 2 failure failure NN cord-005453-4057qib7 12011 3 of of IN cord-005453-4057qib7 12011 4 post post JJ cord-005453-4057qib7 12011 5 - - JJ cord-005453-4057qib7 12011 6 ASCT asct JJ cord-005453-4057qib7 12011 7 CD3 cd3 NN cord-005453-4057qib7 12011 8 reconstitution reconstitution NN cord-005453-4057qib7 12011 9 to to TO cord-005453-4057qib7 12011 10 pre pre JJ cord-005453-4057qib7 12011 11 - - JJ cord-005453-4057qib7 12011 12 ASCT asct JJ cord-005453-4057qib7 12011 13 levels level NNS cord-005453-4057qib7 12011 14 was be VBD cord-005453-4057qib7 12011 15 driven drive VBN cord-005453-4057qib7 12011 16 by by IN cord-005453-4057qib7 12011 17 lack lack NN cord-005453-4057qib7 12011 18 of of IN cord-005453-4057qib7 12011 19 CD4 CD4 NNP cord-005453-4057qib7 12011 20 + + CC cord-005453-4057qib7 12011 21 cell cell NN cord-005453-4057qib7 12011 22 recovery recovery NN cord-005453-4057qib7 12011 23 , , , cord-005453-4057qib7 12011 24 namely namely RB cord-005453-4057qib7 12011 25 CD4+CD45RA+ CD4+CD45RA+ NNP cord-005453-4057qib7 12011 26 cells cell NNS cord-005453-4057qib7 12011 27 with with IN cord-005453-4057qib7 12011 28 a a DT cord-005453-4057qib7 12011 29 median median NN cord-005453-4057qib7 12011 30 of of IN cord-005453-4057qib7 12011 31 21 21 CD cord-005453-4057qib7 12011 32 cells/ cells/ CD cord-005453-4057qib7 12012 1 μL μL NNP cord-005453-4057qib7 12012 2 and and CC cord-005453-4057qib7 12012 3 20 20 CD cord-005453-4057qib7 12012 4 cells/ cells/ CD cord-005453-4057qib7 12013 1 μL μL . cord-005453-4057qib7 12014 1 in in IN cord-005453-4057qib7 12014 2 the the DT cord-005453-4057qib7 12014 3 MM MM NNP cord-005453-4057qib7 12014 4 and and CC cord-005453-4057qib7 12014 5 lymphoma lymphoma NN cord-005453-4057qib7 12014 6 cohorts cohort NNS cord-005453-4057qib7 12014 7 , , , cord-005453-4057qib7 12014 8 respectively respectively RB cord-005453-4057qib7 12014 9 at at IN cord-005453-4057qib7 12014 10 day day NN cord-005453-4057qib7 12014 11 365 365 CD cord-005453-4057qib7 12014 12 ( ( -LRB- cord-005453-4057qib7 12014 13 figures figure NNS cord-005453-4057qib7 12014 14 2 2 CD cord-005453-4057qib7 12014 15 and and CC cord-005453-4057qib7 12014 16 3 3 CD cord-005453-4057qib7 12014 17 ) ) -RRB- cord-005453-4057qib7 12014 18 . . . cord-005453-4057qib7 12015 1 This this DT cord-005453-4057qib7 12015 2 led lead VBD cord-005453-4057qib7 12015 3 to to IN cord-005453-4057qib7 12015 4 markedly markedly RB cord-005453-4057qib7 12015 5 diminished diminish VBN cord-005453-4057qib7 12015 6 CD4 CD4 NNP cord-005453-4057qib7 12015 7 : : : cord-005453-4057qib7 12015 8 CD8 CD8 NNP cord-005453-4057qib7 12015 9 ratios ratio NNS cord-005453-4057qib7 12015 10 through through IN cord-005453-4057qib7 12015 11 day day NN cord-005453-4057qib7 12015 12 365 365 CD cord-005453-4057qib7 12015 13 ( ( -LRB- cord-005453-4057qib7 12015 14 figure figure NN cord-005453-4057qib7 12015 15 4 4 CD cord-005453-4057qib7 12015 16 ) ) -RRB- cord-005453-4057qib7 12015 17 . . . cord-005453-4057qib7 12016 1 [ [ -LRB- cord-005453-4057qib7 12016 2 [ [ -LRB- cord-005453-4057qib7 12016 3 P531 p531 CD cord-005453-4057qib7 12016 4 Image image NN cord-005453-4057qib7 12016 5 ] ] -RRB- cord-005453-4057qib7 12016 6 1 1 CD cord-005453-4057qib7 12016 7 . . . cord-005453-4057qib7 12017 1 Conclusions conclusion NNS cord-005453-4057qib7 12017 2 : : : cord-005453-4057qib7 12018 1 Impaired impaired JJ cord-005453-4057qib7 12018 2 T t NN cord-005453-4057qib7 12018 3 - - HYPH cord-005453-4057qib7 12018 4 cell cell NN cord-005453-4057qib7 12018 5 reconstitution reconstitution NN cord-005453-4057qib7 12018 6 in in IN cord-005453-4057qib7 12018 7 both both DT cord-005453-4057qib7 12018 8 lymphoma lymphoma NN cord-005453-4057qib7 12018 9 and and CC cord-005453-4057qib7 12018 10 MM MM NNP cord-005453-4057qib7 12018 11 continues continue VBZ cord-005453-4057qib7 12018 12 through through IN cord-005453-4057qib7 12018 13 1-year 1-year CD cord-005453-4057qib7 12018 14 post post JJ cord-005453-4057qib7 12018 15 - - JJ cord-005453-4057qib7 12018 16 ASCT asct JJ cord-005453-4057qib7 12018 17 . . . cord-005453-4057qib7 12019 1 As as IN cord-005453-4057qib7 12019 2 shown show VBN cord-005453-4057qib7 12019 3 , , , cord-005453-4057qib7 12019 4 a a DT cord-005453-4057qib7 12019 5 larger large JJR cord-005453-4057qib7 12019 6 percent percent NN cord-005453-4057qib7 12019 7 reduction reduction NN cord-005453-4057qib7 12019 8 in in IN cord-005453-4057qib7 12019 9 median median JJ cord-005453-4057qib7 12019 10 CD3 CD3 NNP cord-005453-4057qib7 12019 11 and and CC cord-005453-4057qib7 12019 12 CD4 CD4 NNP cord-005453-4057qib7 12019 13 counts count VBZ cord-005453-4057qib7 12019 14 through through IN cord-005453-4057qib7 12019 15 day day NN cord-005453-4057qib7 12019 16 365 365 CD cord-005453-4057qib7 12019 17 was be VBD cord-005453-4057qib7 12019 18 appreciated appreciate VBN cord-005453-4057qib7 12019 19 in in IN cord-005453-4057qib7 12019 20 MM MM NNP cord-005453-4057qib7 12019 21 compared compare VBN cord-005453-4057qib7 12019 22 to to IN cord-005453-4057qib7 12019 23 lymphoma lymphoma NN cord-005453-4057qib7 12019 24 leading lead VBG cord-005453-4057qib7 12019 25 to to IN cord-005453-4057qib7 12019 26 the the DT cord-005453-4057qib7 12019 27 nonsignificant nonsignificant JJ cord-005453-4057qib7 12019 28 differences difference NNS cord-005453-4057qib7 12019 29 in in IN cord-005453-4057qib7 12019 30 the the DT cord-005453-4057qib7 12019 31 post post JJ cord-005453-4057qib7 12019 32 - - JJ cord-005453-4057qib7 12019 33 ASCT asct JJ cord-005453-4057qib7 12019 34 absolute absolute JJ cord-005453-4057qib7 12019 35 counts count NNS cord-005453-4057qib7 12019 36 despite despite IN cord-005453-4057qib7 12019 37 significantly significantly RB cord-005453-4057qib7 12019 38 higher high JJR cord-005453-4057qib7 12019 39 pre pre JJ cord-005453-4057qib7 12019 40 - - JJ cord-005453-4057qib7 12019 41 ASCT asct JJ cord-005453-4057qib7 12019 42 counts count NNS cord-005453-4057qib7 12019 43 in in IN cord-005453-4057qib7 12019 44 the the DT cord-005453-4057qib7 12019 45 MM MM NNP cord-005453-4057qib7 12019 46 cohort cohort NN cord-005453-4057qib7 12019 47 . . . cord-005453-4057qib7 12020 1 Impaired impaired JJ cord-005453-4057qib7 12020 2 recovery recovery NN cord-005453-4057qib7 12020 3 of of IN cord-005453-4057qib7 12020 4 CD4 CD4 NNP cord-005453-4057qib7 12020 5 T T NNP cord-005453-4057qib7 12020 6 - - HYPH cord-005453-4057qib7 12020 7 cells cell NNS cord-005453-4057qib7 12020 8 may may MD cord-005453-4057qib7 12020 9 increase increase VB cord-005453-4057qib7 12020 10 the the DT cord-005453-4057qib7 12020 11 risk risk NN cord-005453-4057qib7 12020 12 of of IN cord-005453-4057qib7 12020 13 opportunistic opportunistic JJ cord-005453-4057qib7 12020 14 infections infection NNS cord-005453-4057qib7 12020 15 , , , cord-005453-4057qib7 12020 16 decrease decrease VB cord-005453-4057qib7 12020 17 the the DT cord-005453-4057qib7 12020 18 response response NN cord-005453-4057qib7 12020 19 to to IN cord-005453-4057qib7 12020 20 vaccination vaccination NN cord-005453-4057qib7 12020 21 and and CC cord-005453-4057qib7 12020 22 lead lead VB cord-005453-4057qib7 12020 23 to to IN cord-005453-4057qib7 12020 24 ineffective ineffective JJ cord-005453-4057qib7 12020 25 anti anti JJ cord-005453-4057qib7 12020 26 - - JJ cord-005453-4057qib7 12020 27 tumor tumor JJ cord-005453-4057qib7 12020 28 response response NN cord-005453-4057qib7 12020 29 . . . cord-005453-4057qib7 12021 1 Further further JJ cord-005453-4057qib7 12021 2 prospective prospective JJ cord-005453-4057qib7 12021 3 and and CC cord-005453-4057qib7 12021 4 larger large JJR cord-005453-4057qib7 12021 5 retrospective retrospective JJ cord-005453-4057qib7 12021 6 studies study NNS cord-005453-4057qib7 12021 7 like like IN cord-005453-4057qib7 12021 8 this this DT cord-005453-4057qib7 12021 9 should should MD cord-005453-4057qib7 12021 10 continue continue VB cord-005453-4057qib7 12021 11 in in IN cord-005453-4057qib7 12021 12 the the DT cord-005453-4057qib7 12021 13 modern modern JJ cord-005453-4057qib7 12021 14 - - HYPH cord-005453-4057qib7 12021 15 era era NN cord-005453-4057qib7 12021 16 as as IN cord-005453-4057qib7 12021 17 they -PRON- PRP cord-005453-4057qib7 12021 18 may may MD cord-005453-4057qib7 12021 19 help help VB cord-005453-4057qib7 12021 20 predict predict VB cord-005453-4057qib7 12021 21 responses response NNS cord-005453-4057qib7 12021 22 to to IN cord-005453-4057qib7 12021 23 further further JJ cord-005453-4057qib7 12021 24 interventions intervention NNS cord-005453-4057qib7 12021 25 requiring require VBG cord-005453-4057qib7 12021 26 a a DT cord-005453-4057qib7 12021 27 robust robust JJ cord-005453-4057qib7 12021 28 T t NN cord-005453-4057qib7 12021 29 - - HYPH cord-005453-4057qib7 12021 30 cell cell NN cord-005453-4057qib7 12021 31 repertoire repertoire NN cord-005453-4057qib7 12021 32 for for IN cord-005453-4057qib7 12021 33 maximal maximal JJ cord-005453-4057qib7 12021 34 efficacy efficacy NN cord-005453-4057qib7 12021 35 such such JJ cord-005453-4057qib7 12021 36 as as IN cord-005453-4057qib7 12021 37 CAR car NN cord-005453-4057qib7 12021 38 - - HYPH cord-005453-4057qib7 12021 39 T t NN cord-005453-4057qib7 12021 40 cell cell NN cord-005453-4057qib7 12021 41 and and CC cord-005453-4057qib7 12021 42 BiTE bite NN cord-005453-4057qib7 12021 43 therapies therapy NNS cord-005453-4057qib7 12021 44 . . . cord-005453-4057qib7 12022 1 Disclosure disclosure NN cord-005453-4057qib7 12022 2 : : : cord-005453-4057qib7 12023 1 Nothing nothing NN cord-005453-4057qib7 12023 2 to to TO cord-005453-4057qib7 12023 3 declare declare VB cord-005453-4057qib7 12023 4 P532 P532 NNP cord-005453-4057qib7 12023 5 Peri Peri NNP cord-005453-4057qib7 12023 6 - - HYPH cord-005453-4057qib7 12023 7 transplant transplant NN cord-005453-4057qib7 12023 8 detection detection NN cord-005453-4057qib7 12023 9 of of IN cord-005453-4057qib7 12023 10 measurable measurable JJ cord-005453-4057qib7 12023 11 residual residual JJ cord-005453-4057qib7 12023 12 disease disease NN cord-005453-4057qib7 12023 13 by by IN cord-005453-4057qib7 12023 14 multicolor multicolor JJ cord-005453-4057qib7 12023 15 flow flow NN cord-005453-4057qib7 12023 16 cytometry cytometry NN cord-005453-4057qib7 12023 17 is be VBZ cord-005453-4057qib7 12023 18 highly highly RB cord-005453-4057qib7 12023 19 predictive predictive JJ cord-005453-4057qib7 12023 20 for for IN cord-005453-4057qib7 12023 21 relapse relapse NN cord-005453-4057qib7 12023 22 in in IN cord-005453-4057qib7 12023 23 acute acute JJ cord-005453-4057qib7 12023 24 myeloid myeloid JJ cord-005453-4057qib7 12023 25 leukemia leukemia NN cord-005453-4057qib7 12023 26 patients patient NNS cord-005453-4057qib7 12024 1 Background background NN cord-005453-4057qib7 12024 2 : : : cord-005453-4057qib7 12025 1 Presence presence NN cord-005453-4057qib7 12025 2 of of IN cord-005453-4057qib7 12025 3 measurable measurable JJ cord-005453-4057qib7 12025 4 residual residual JJ cord-005453-4057qib7 12025 5 disease disease NN cord-005453-4057qib7 12025 6 ( ( -LRB- cord-005453-4057qib7 12025 7 MRD MRD NNP cord-005453-4057qib7 12025 8 ) ) -RRB- cord-005453-4057qib7 12025 9 prior prior RB cord-005453-4057qib7 12025 10 to to IN cord-005453-4057qib7 12025 11 allo allo NNP cord-005453-4057qib7 12025 12 - - HYPH cord-005453-4057qib7 12025 13 SCT SCT NNP cord-005453-4057qib7 12025 14 has have VBZ cord-005453-4057qib7 12025 15 been be VBN cord-005453-4057qib7 12025 16 shown show VBN cord-005453-4057qib7 12025 17 to to TO cord-005453-4057qib7 12025 18 be be VB cord-005453-4057qib7 12025 19 predictive predictive JJ cord-005453-4057qib7 12025 20 for for IN cord-005453-4057qib7 12025 21 survival survival NN cord-005453-4057qib7 12025 22 in in IN cord-005453-4057qib7 12025 23 patients patient NNS cord-005453-4057qib7 12025 24 in in IN cord-005453-4057qib7 12025 25 hematological hematological JJ cord-005453-4057qib7 12025 26 CR cr NN cord-005453-4057qib7 12025 27 of of IN cord-005453-4057qib7 12025 28 AML AML NNP cord-005453-4057qib7 12025 29 . . . cord-005453-4057qib7 12026 1 In in IN cord-005453-4057qib7 12026 2 this this DT cord-005453-4057qib7 12026 3 study study NN cord-005453-4057qib7 12026 4 we -PRON- PRP cord-005453-4057qib7 12026 5 analyzed analyze VBD cord-005453-4057qib7 12026 6 the the DT cord-005453-4057qib7 12026 7 impact impact NN cord-005453-4057qib7 12026 8 of of IN cord-005453-4057qib7 12026 9 MRD MRD NNP cord-005453-4057qib7 12026 10 in in IN cord-005453-4057qib7 12026 11 such such JJ cord-005453-4057qib7 12026 12 patients patient NNS cord-005453-4057qib7 12026 13 measured measure VBN cord-005453-4057qib7 12026 14 by by IN cord-005453-4057qib7 12026 15 8-color 8-color CD cord-005453-4057qib7 12026 16 multiparameter multiparameter NNP cord-005453-4057qib7 12026 17 flow flow NN cord-005453-4057qib7 12026 18 cytometry cytometry NN cord-005453-4057qib7 12026 19 ( ( -LRB- cord-005453-4057qib7 12026 20 MFC MFC NNP cord-005453-4057qib7 12026 21 ) ) -RRB- cord-005453-4057qib7 12026 22 prior prior RB cord-005453-4057qib7 12026 23 to to IN cord-005453-4057qib7 12026 24 and and CC cord-005453-4057qib7 12026 25 on on IN cord-005453-4057qib7 12026 26 day day NN cord-005453-4057qib7 12026 27 +100 +100 HYPH cord-005453-4057qib7 12026 28 post post NN cord-005453-4057qib7 12026 29 - - NN cord-005453-4057qib7 12026 30 transplant transplant NN cord-005453-4057qib7 12026 31 . . . cord-005453-4057qib7 12027 1 Methods method NNS cord-005453-4057qib7 12027 2 : : : cord-005453-4057qib7 12027 3 The the DT cord-005453-4057qib7 12027 4 bone bone NN cord-005453-4057qib7 12027 5 marrow marrow NN cord-005453-4057qib7 12027 6 samples sample NNS cord-005453-4057qib7 12027 7 immediately immediately RB cord-005453-4057qib7 12027 8 prior prior RB cord-005453-4057qib7 12027 9 to to IN cord-005453-4057qib7 12027 10 allo allo NNP cord-005453-4057qib7 12027 11 - - HYPH cord-005453-4057qib7 12027 12 SCT SCT NNP cord-005453-4057qib7 12027 13 and and CC cord-005453-4057qib7 12027 14 on on IN cord-005453-4057qib7 12027 15 day day NN cord-005453-4057qib7 12027 16 +100 +100 HYPH cord-005453-4057qib7 12027 17 post post NN cord-005453-4057qib7 12027 18 - - NN cord-005453-4057qib7 12027 19 transplant transplant NN cord-005453-4057qib7 12027 20 were be VBD cord-005453-4057qib7 12027 21 retrospectively retrospectively RB cord-005453-4057qib7 12027 22 analyzed analyze VBN cord-005453-4057qib7 12027 23 . . . cord-005453-4057qib7 12028 1 MRD MRD NNP cord-005453-4057qib7 12028 2 evaluation evaluation NN cord-005453-4057qib7 12028 3 was be VBD cord-005453-4057qib7 12028 4 carried carry VBN cord-005453-4057qib7 12028 5 out out RP cord-005453-4057qib7 12028 6 with with IN cord-005453-4057qib7 12028 7 antibodies antibody NNS cord-005453-4057qib7 12028 8 against against IN cord-005453-4057qib7 12028 9 : : : cord-005453-4057qib7 12029 1 ( ( -LRB- cord-005453-4057qib7 12029 2 1 1 LS cord-005453-4057qib7 12029 3 ) ) -RRB- cord-005453-4057qib7 12029 4 Results result NNS cord-005453-4057qib7 12029 5 : : : cord-005453-4057qib7 12030 1 A a DT cord-005453-4057qib7 12030 2 number number NN cord-005453-4057qib7 12030 3 of of IN cord-005453-4057qib7 12030 4 55 55 CD cord-005453-4057qib7 12030 5 AML AML NNP cord-005453-4057qib7 12030 6 patients patient NNS cord-005453-4057qib7 12030 7 ( ( -LRB- cord-005453-4057qib7 12030 8 male male JJ cord-005453-4057qib7 12030 9 , , , cord-005453-4057qib7 12030 10 n=35 n=35 RB cord-005453-4057qib7 12030 11 ) ) -RRB- cord-005453-4057qib7 12030 12 with with IN cord-005453-4057qib7 12030 13 median median JJ cord-005453-4057qib7 12030 14 age age NN cord-005453-4057qib7 12030 15 of of IN cord-005453-4057qib7 12030 16 57 57 CD cord-005453-4057qib7 12030 17 years year NNS cord-005453-4057qib7 12030 18 ( ( -LRB- cord-005453-4057qib7 12030 19 23 23 CD cord-005453-4057qib7 12030 20 - - SYM cord-005453-4057qib7 12030 21 77 77 CD cord-005453-4057qib7 12030 22 ) ) -RRB- cord-005453-4057qib7 12030 23 in in IN cord-005453-4057qib7 12030 24 hematological hematological JJ cord-005453-4057qib7 12030 25 CR cr NN cord-005453-4057qib7 12030 26 prior prior RB cord-005453-4057qib7 12030 27 to to IN cord-005453-4057qib7 12030 28 allo allo NNP cord-005453-4057qib7 12030 29 - - HYPH cord-005453-4057qib7 12030 30 SCT SCT NNP cord-005453-4057qib7 12030 31 were be VBD cord-005453-4057qib7 12030 32 enrolled enrol VBN cord-005453-4057qib7 12030 33 in in IN cord-005453-4057qib7 12030 34 the the DT cord-005453-4057qib7 12030 35 study study NN cord-005453-4057qib7 12030 36 . . . cord-005453-4057qib7 12031 1 We -PRON- PRP cord-005453-4057qib7 12031 2 observed observe VBD cord-005453-4057qib7 12031 3 lower low JJR cord-005453-4057qib7 12031 4 survival survival NN cord-005453-4057qib7 12031 5 in in IN cord-005453-4057qib7 12031 6 patients patient NNS cord-005453-4057qib7 12031 7 with with IN cord-005453-4057qib7 12031 8 MRD MRD NNP cord-005453-4057qib7 12031 9 by by IN cord-005453-4057qib7 12031 10 MFC MFC NNP cord-005453-4057qib7 12031 11 pre pre NN cord-005453-4057qib7 12031 12 - - NN cord-005453-4057qib7 12031 13 transplant transplant JJ cord-005453-4057qib7 12031 14 ( ( -LRB- cord-005453-4057qib7 12031 15 2y 2y NNP cord-005453-4057qib7 12031 16 OS OS NNP cord-005453-4057qib7 12031 17 : : : cord-005453-4057qib7 12031 18 61 61 CD cord-005453-4057qib7 12031 19 % % NN cord-005453-4057qib7 12031 20 ( ( -LRB- cord-005453-4057qib7 12031 21 41 41 CD cord-005453-4057qib7 12031 22 - - SYM cord-005453-4057qib7 12031 23 81 81 CD cord-005453-4057qib7 12031 24 % % NN cord-005453-4057qib7 12031 25 ) ) -RRB- cord-005453-4057qib7 12031 26 vs. vs. NN cord-005453-4057qib7 12031 27 92 92 CD cord-005453-4057qib7 12031 28 % % NN cord-005453-4057qib7 12031 29 ( ( -LRB- cord-005453-4057qib7 12031 30 82 82 CD cord-005453-4057qib7 12031 31 - - SYM cord-005453-4057qib7 12031 32 100 100 CD cord-005453-4057qib7 12031 33 % % NN cord-005453-4057qib7 12031 34 ) ) -RRB- cord-005453-4057qib7 12031 35 , , , cord-005453-4057qib7 12031 36 p=0.018 p=0.018 NNP cord-005453-4057qib7 12031 37 ) ) -RRB- cord-005453-4057qib7 12031 38 due due JJ cord-005453-4057qib7 12031 39 to to IN cord-005453-4057qib7 12031 40 increased increase VBN cord-005453-4057qib7 12031 41 relapse relapse NN cord-005453-4057qib7 12031 42 incidence incidence NN cord-005453-4057qib7 12031 43 ( ( -LRB- cord-005453-4057qib7 12031 44 35 35 CD cord-005453-4057qib7 12031 45 % % NN cord-005453-4057qib7 12031 46 ( ( -LRB- cord-005453-4057qib7 12031 47 17 17 CD cord-005453-4057qib7 12031 48 - - SYM cord-005453-4057qib7 12031 49 53 53 CD cord-005453-4057qib7 12031 50 % % NN cord-005453-4057qib7 12031 51 ) ) -RRB- cord-005453-4057qib7 12031 52 vs. vs. IN cord-005453-4057qib7 12031 53 8 8 CD cord-005453-4057qib7 12031 54 % % NN cord-005453-4057qib7 12031 55 ( ( -LRB- cord-005453-4057qib7 12031 56 0 0 CD cord-005453-4057qib7 12031 57 - - SYM cord-005453-4057qib7 12031 58 18 18 CD cord-005453-4057qib7 12031 59 % % NN cord-005453-4057qib7 12031 60 ) ) -RRB- cord-005453-4057qib7 12031 61 , , , cord-005453-4057qib7 12031 62 p=0.009 p=0.009 NN cord-005453-4057qib7 12031 63 ) ) -RRB- cord-005453-4057qib7 12031 64 . . . cord-005453-4057qib7 12032 1 In in IN cord-005453-4057qib7 12032 2 multivariate multivariate JJ cord-005453-4057qib7 12032 3 analysis analysis NN cord-005453-4057qib7 12032 4 , , , cord-005453-4057qib7 12032 5 MRD MRD NNP cord-005453-4057qib7 12032 6 pos pos NNP cord-005453-4057qib7 12032 7 prior prior RB cord-005453-4057qib7 12032 8 to to IN cord-005453-4057qib7 12032 9 allo allo NNP cord-005453-4057qib7 12032 10 - - HYPH cord-005453-4057qib7 12032 11 SCT SCT NNP cord-005453-4057qib7 12032 12 has have VBZ cord-005453-4057qib7 12032 13 strong strong JJ cord-005453-4057qib7 12032 14 significant significant JJ cord-005453-4057qib7 12032 15 impact impact NN cord-005453-4057qib7 12032 16 on on IN cord-005453-4057qib7 12032 17 OS OS NNP cord-005453-4057qib7 12032 18 ( ( -LRB- cord-005453-4057qib7 12032 19 HR HR NNP cord-005453-4057qib7 12032 20 6.5 6.5 CD cord-005453-4057qib7 12032 21 ( ( -LRB- cord-005453-4057qib7 12032 22 1.5 1.5 CD cord-005453-4057qib7 12032 23 -30 -30 CD cord-005453-4057qib7 12032 24 ) ) -RRB- cord-005453-4057qib7 12032 25 , , , cord-005453-4057qib7 12032 26 p=0.015 p=0.015 NNP cord-005453-4057qib7 12032 27 ) ) -RRB- cord-005453-4057qib7 12032 28 . . . cord-005453-4057qib7 12033 1 Of of IN cord-005453-4057qib7 12033 2 55 55 CD cord-005453-4057qib7 12033 3 patients patient NNS cord-005453-4057qib7 12033 4 , , , cord-005453-4057qib7 12033 5 a a DT cord-005453-4057qib7 12033 6 sample sample NN cord-005453-4057qib7 12033 7 both both CC cord-005453-4057qib7 12033 8 before before IN cord-005453-4057qib7 12033 9 and and CC cord-005453-4057qib7 12033 10 on on IN cord-005453-4057qib7 12033 11 day day NN cord-005453-4057qib7 12033 12 +100 +100 NNS cord-005453-4057qib7 12033 13 after after IN cord-005453-4057qib7 12033 14 transplantation transplantation NN cord-005453-4057qib7 12033 15 was be VBD cord-005453-4057qib7 12033 16 available available JJ cord-005453-4057qib7 12033 17 in in IN cord-005453-4057qib7 12033 18 33 33 CD cord-005453-4057qib7 12033 19 patients patient NNS cord-005453-4057qib7 12033 20 . . . cord-005453-4057qib7 12034 1 Of of IN cord-005453-4057qib7 12034 2 those those DT cord-005453-4057qib7 12034 3 33 33 CD cord-005453-4057qib7 12034 4 patients patient NNS cord-005453-4057qib7 12034 5 , , , cord-005453-4057qib7 12034 6 15 15 CD cord-005453-4057qib7 12034 7 ( ( -LRB- cord-005453-4057qib7 12034 8 46 46 CD cord-005453-4057qib7 12034 9 % % NN cord-005453-4057qib7 12034 10 ) ) -RRB- cord-005453-4057qib7 12034 11 were be VBD cord-005453-4057qib7 12034 12 MRD MRD NNP cord-005453-4057qib7 12034 13 negative negative JJ cord-005453-4057qib7 12034 14 prior prior RB cord-005453-4057qib7 12034 15 to to IN cord-005453-4057qib7 12034 16 transplant transplant NN cord-005453-4057qib7 12034 17 and and CC cord-005453-4057qib7 12034 18 on on IN cord-005453-4057qib7 12034 19 day day NN cord-005453-4057qib7 12034 20 +100 +100 NNS cord-005453-4057qib7 12034 21 ( ( -LRB- cord-005453-4057qib7 12034 22 MRD MRD NNP cord-005453-4057qib7 12034 23 neg neg NNP cord-005453-4057qib7 12034 24 / / SYM cord-005453-4057qib7 12034 25 neg neg NNP cord-005453-4057qib7 12034 26 ) ) -RRB- cord-005453-4057qib7 12034 27 ; ; : cord-005453-4057qib7 12034 28 14 14 CD cord-005453-4057qib7 12034 29 ( ( -LRB- cord-005453-4057qib7 12034 30 42 42 CD cord-005453-4057qib7 12034 31 % % NN cord-005453-4057qib7 12034 32 ) ) -RRB- cord-005453-4057qib7 12034 33 patients patient NNS cord-005453-4057qib7 12034 34 were be VBD cord-005453-4057qib7 12034 35 MRD MRD NNP cord-005453-4057qib7 12034 36 positive positive JJ cord-005453-4057qib7 12034 37 prior prior RB cord-005453-4057qib7 12034 38 to to IN cord-005453-4057qib7 12034 39 transplant transplant NN cord-005453-4057qib7 12034 40 and and CC cord-005453-4057qib7 12034 41 negative negative JJ cord-005453-4057qib7 12034 42 at at IN cord-005453-4057qib7 12034 43 day day NN cord-005453-4057qib7 12034 44 +100 +100 . cord-005453-4057qib7 12035 1 ( ( -LRB- cord-005453-4057qib7 12035 2 MRD MRD NNP cord-005453-4057qib7 12035 3 pos pos NNP cord-005453-4057qib7 12035 4 / / SYM cord-005453-4057qib7 12035 5 neg neg NNP cord-005453-4057qib7 12035 6 ) ) -RRB- cord-005453-4057qib7 12035 7 ; ; : cord-005453-4057qib7 12035 8 and and CC cord-005453-4057qib7 12035 9 4 4 CD cord-005453-4057qib7 12035 10 ( ( -LRB- cord-005453-4057qib7 12035 11 12 12 CD cord-005453-4057qib7 12035 12 % % NN cord-005453-4057qib7 12035 13 ) ) -RRB- cord-005453-4057qib7 12035 14 patients patient NNS cord-005453-4057qib7 12035 15 were be VBD cord-005453-4057qib7 12035 16 MRD MRD NNP cord-005453-4057qib7 12035 17 positive positive JJ cord-005453-4057qib7 12035 18 at at IN cord-005453-4057qib7 12035 19 both both DT cord-005453-4057qib7 12035 20 timepoints timepoint NNS cord-005453-4057qib7 12035 21 ( ( -LRB- cord-005453-4057qib7 12035 22 MRD MRD NNP cord-005453-4057qib7 12035 23 pos pos NNP cord-005453-4057qib7 12035 24 / / SYM cord-005453-4057qib7 12035 25 pos pos NNP cord-005453-4057qib7 12035 26 ) ) -RRB- cord-005453-4057qib7 12035 27 . . . cord-005453-4057qib7 12036 1 DFS DFS NNP cord-005453-4057qib7 12036 2 and and CC cord-005453-4057qib7 12036 3 OS OS NNP cord-005453-4057qib7 12036 4 for for IN cord-005453-4057qib7 12036 5 these these DT cord-005453-4057qib7 12036 6 three three CD cord-005453-4057qib7 12036 7 groups group NNS cord-005453-4057qib7 12036 8 were be VBD cord-005453-4057qib7 12036 9 as as IN cord-005453-4057qib7 12036 10 follow follow NN cord-005453-4057qib7 12036 11 : : : cord-005453-4057qib7 12037 1 2y 2y NNP cord-005453-4057qib7 12037 2 DFS DFS NNP cord-005453-4057qib7 12037 3 : : : cord-005453-4057qib7 12038 1 MRD MRD NNP cord-005453-4057qib7 12038 2 neg neg NNP cord-005453-4057qib7 12038 3 / / SYM cord-005453-4057qib7 12038 4 neg neg NN cord-005453-4057qib7 12038 5 : : : cord-005453-4057qib7 12038 6 93 93 CD cord-005453-4057qib7 12038 7 % % NN cord-005453-4057qib7 12038 8 ( ( -LRB- cord-005453-4057qib7 12038 9 80 80 CD cord-005453-4057qib7 12038 10 - - SYM cord-005453-4057qib7 12038 11 100 100 CD cord-005453-4057qib7 12038 12 % % NN cord-005453-4057qib7 12038 13 ) ) -RRB- cord-005453-4057qib7 12038 14 , , , cord-005453-4057qib7 12038 15 MRD MRD NNP cord-005453-4057qib7 12038 16 pos pos NNP cord-005453-4057qib7 12038 17 / / SYM cord-005453-4057qib7 12038 18 neg neg NN cord-005453-4057qib7 12038 19 : : : cord-005453-4057qib7 12038 20 78 78 CD cord-005453-4057qib7 12038 21 % % NN cord-005453-4057qib7 12038 22 ( ( -LRB- cord-005453-4057qib7 12038 23 56 56 CD cord-005453-4057qib7 12038 24 - - SYM cord-005453-4057qib7 12038 25 100 100 CD cord-005453-4057qib7 12038 26 % % NN cord-005453-4057qib7 12038 27 ) ) -RRB- cord-005453-4057qib7 12038 28 ; ; : cord-005453-4057qib7 12038 29 MRD MRD NNP cord-005453-4057qib7 12038 30 pos pos NNP cord-005453-4057qib7 12038 31 / / SYM cord-005453-4057qib7 12038 32 pos pos NN cord-005453-4057qib7 12038 33 : : : cord-005453-4057qib7 12038 34 25 25 CD cord-005453-4057qib7 12038 35 % % NN cord-005453-4057qib7 12038 36 ( ( -LRB- cord-005453-4057qib7 12038 37 0 0 CD cord-005453-4057qib7 12038 38 - - SYM cord-005453-4057qib7 12038 39 75 75 CD cord-005453-4057qib7 12038 40 % % NN cord-005453-4057qib7 12038 41 , , , cord-005453-4057qib7 12038 42 p=0.006 p=0.006 NNP cord-005453-4057qib7 12038 43 ) ) -RRB- cord-005453-4057qib7 12038 44 ; ; : cord-005453-4057qib7 12038 45 2y 2y NNP cord-005453-4057qib7 12038 46 OS OS NNP cord-005453-4057qib7 12038 47 : : : cord-005453-4057qib7 12039 1 MRD MRD NNP cord-005453-4057qib7 12039 2 neg neg NNP cord-005453-4057qib7 12039 3 / / SYM cord-005453-4057qib7 12039 4 neg neg NNP cord-005453-4057qib7 12039 5 : : : cord-005453-4057qib7 12039 6 100 100 CD cord-005453-4057qib7 12039 7 % % NN cord-005453-4057qib7 12039 8 ; ; : cord-005453-4057qib7 12039 9 MRD MRD NNP cord-005453-4057qib7 12039 10 pos pos NNP cord-005453-4057qib7 12039 11 / / SYM cord-005453-4057qib7 12039 12 neg neg NN cord-005453-4057qib7 12039 13 : : : cord-005453-4057qib7 12039 14 93 93 CD cord-005453-4057qib7 12039 15 % % NN cord-005453-4057qib7 12039 16 ( ( -LRB- cord-005453-4057qib7 12039 17 79 79 CD cord-005453-4057qib7 12039 18 - - SYM cord-005453-4057qib7 12039 19 100 100 CD cord-005453-4057qib7 12039 20 % % NN cord-005453-4057qib7 12039 21 ) ) -RRB- cord-005453-4057qib7 12039 22 ; ; : cord-005453-4057qib7 12039 23 MRD MRD NNP cord-005453-4057qib7 12039 24 pos pos NNP cord-005453-4057qib7 12039 25 / / SYM cord-005453-4057qib7 12039 26 pos pos NN cord-005453-4057qib7 12039 27 : : : cord-005453-4057qib7 12039 28 25 25 CD cord-005453-4057qib7 12039 29 % % NN cord-005453-4057qib7 12039 30 ( ( -LRB- cord-005453-4057qib7 12039 31 0 0 CD cord-005453-4057qib7 12039 32 - - SYM cord-005453-4057qib7 12039 33 75 75 CD cord-005453-4057qib7 12039 34 % % NN cord-005453-4057qib7 12039 35 , , , cord-005453-4057qib7 12039 36 p p NN cord-005453-4057qib7 12039 37 < < XX cord-005453-4057qib7 12039 38 0.001 0.001 CD cord-005453-4057qib7 12039 39 ) ) -RRB- cord-005453-4057qib7 12039 40 . . . cord-005453-4057qib7 12040 1 Upon upon IN cord-005453-4057qib7 12040 2 multivariate multivariate JJ cord-005453-4057qib7 12040 3 analysis analysis NN cord-005453-4057qib7 12040 4 , , , cord-005453-4057qib7 12040 5 the the DT cord-005453-4057qib7 12040 6 MRD MRD NNP cord-005453-4057qib7 12040 7 status status NN cord-005453-4057qib7 12040 8 prior prior RB cord-005453-4057qib7 12040 9 to to IN cord-005453-4057qib7 12040 10 transplant transplant NN cord-005453-4057qib7 12040 11 and and CC cord-005453-4057qib7 12040 12 on on IN cord-005453-4057qib7 12040 13 day day NN cord-005453-4057qib7 12040 14 +100 +100 NNP cord-005453-4057qib7 12040 15 showed show VBD cord-005453-4057qib7 12040 16 strong strong JJ cord-005453-4057qib7 12040 17 significant significant JJ cord-005453-4057qib7 12040 18 impact impact NN cord-005453-4057qib7 12040 19 on on IN cord-005453-4057qib7 12040 20 DFS DFS NNP cord-005453-4057qib7 12040 21 ( ( -LRB- cord-005453-4057qib7 12040 22 HR HR NNP cord-005453-4057qib7 12040 23 3.6 3.6 CD cord-005453-4057qib7 12040 24 ( ( -LRB- cord-005453-4057qib7 12040 25 1.3 1.3 CD cord-005453-4057qib7 12040 26 -9.9 -9.9 NFP cord-005453-4057qib7 12040 27 ) ) -RRB- cord-005453-4057qib7 12040 28 , , , cord-005453-4057qib7 12040 29 p=0.01 p=0.01 NNP cord-005453-4057qib7 12040 30 ) ) -RRB- cord-005453-4057qib7 12040 31 and and CC cord-005453-4057qib7 12040 32 OS OS NNP cord-005453-4057qib7 12040 33 ) ) -RRB- cord-005453-4057qib7 12040 34 , , , cord-005453-4057qib7 12040 35 p=0.017 p=0.017 NNS cord-005453-4057qib7 12040 36 ) ) -RRB- cord-005453-4057qib7 12040 37 . . . cord-005453-4057qib7 12041 1 We -PRON- PRP cord-005453-4057qib7 12041 2 did do VBD cord-005453-4057qib7 12041 3 not not RB cord-005453-4057qib7 12041 4 observe observe VB cord-005453-4057qib7 12041 5 any any DT cord-005453-4057qib7 12041 6 significant significant JJ cord-005453-4057qib7 12041 7 impact impact NN cord-005453-4057qib7 12041 8 of of IN cord-005453-4057qib7 12041 9 other other JJ cord-005453-4057qib7 12041 10 factors factor NNS cord-005453-4057qib7 12041 11 included include VBN cord-005453-4057qib7 12041 12 in in IN cord-005453-4057qib7 12041 13 the the DT cord-005453-4057qib7 12041 14 multivariate multivariate JJ cord-005453-4057qib7 12041 15 analysis analysis NN cord-005453-4057qib7 12041 16 ( ( -LRB- cord-005453-4057qib7 12041 17 patient patient NN cord-005453-4057qib7 12041 18 's 's POS cord-005453-4057qib7 12041 19 age age NN cord-005453-4057qib7 12041 20 , , , cord-005453-4057qib7 12041 21 patient patient NNP cord-005453-4057qib7 12041 22 's 's POS cord-005453-4057qib7 12041 23 sex sex NN cord-005453-4057qib7 12041 24 , , , cord-005453-4057qib7 12041 25 and and CC cord-005453-4057qib7 12041 26 recipient/ recipient/ JJ cord-005453-4057qib7 12041 27 donor donor NN cord-005453-4057qib7 12041 28 sex sex NN cord-005453-4057qib7 12041 29 constellation constellation NN cord-005453-4057qib7 12041 30 ) ) -RRB- cord-005453-4057qib7 12041 31 . . . cord-005453-4057qib7 12042 1 Conclusions conclusion NNS cord-005453-4057qib7 12042 2 : : : cord-005453-4057qib7 12043 1 MRD MRD NNP cord-005453-4057qib7 12043 2 positivity positivity NN cord-005453-4057qib7 12043 3 prior prior RB cord-005453-4057qib7 12043 4 to to IN cord-005453-4057qib7 12043 5 allotransplant allotransplant JJ cord-005453-4057qib7 12043 6 and and CC cord-005453-4057qib7 12043 7 at at IN cord-005453-4057qib7 12043 8 day day NN cord-005453-4057qib7 12043 9 +100 +100 NNS cord-005453-4057qib7 12043 10 by by IN cord-005453-4057qib7 12043 11 MFC MFC NNP cord-005453-4057qib7 12043 12 is be VBZ cord-005453-4057qib7 12043 13 highly highly RB cord-005453-4057qib7 12043 14 predictive predictive JJ cord-005453-4057qib7 12043 15 for for IN cord-005453-4057qib7 12043 16 survival survival NN cord-005453-4057qib7 12043 17 after after IN cord-005453-4057qib7 12043 18 allo allo NN cord-005453-4057qib7 12043 19 - - HYPH cord-005453-4057qib7 12043 20 SCT SCT NNP cord-005453-4057qib7 12043 21 . . . cord-005453-4057qib7 12044 1 Disclosure disclosure NN cord-005453-4057qib7 12044 2 : : : cord-005453-4057qib7 12044 3 Nothing nothing NN cord-005453-4057qib7 12044 4 to to TO cord-005453-4057qib7 12044 5 declaire declaire VB cord-005453-4057qib7 12044 6 Background background NN cord-005453-4057qib7 12044 7 : : : cord-005453-4057qib7 12045 1 Immune immune JJ cord-005453-4057qib7 12045 2 reconstitution reconstitution NN cord-005453-4057qib7 12045 3 is be VBZ cord-005453-4057qib7 12045 4 a a DT cord-005453-4057qib7 12045 5 critical critical JJ cord-005453-4057qib7 12045 6 factor factor NN cord-005453-4057qib7 12045 7 for for IN cord-005453-4057qib7 12045 8 risk risk NN cord-005453-4057qib7 12045 9 assessment assessment NN cord-005453-4057qib7 12045 10 of of IN cord-005453-4057qib7 12045 11 life life NN cord-005453-4057qib7 12045 12 threatening threaten VBG cord-005453-4057qib7 12045 13 infections infection NNS cord-005453-4057qib7 12045 14 and and CC cord-005453-4057qib7 12045 15 long long JJ cord-005453-4057qib7 12045 16 - - HYPH cord-005453-4057qib7 12045 17 term term NN cord-005453-4057qib7 12045 18 survival survival NN cord-005453-4057qib7 12045 19 in in IN cord-005453-4057qib7 12045 20 patients patient NNS cord-005453-4057qib7 12045 21 undergoing undergo VBG cord-005453-4057qib7 12045 22 allogeneic allogeneic IN cord-005453-4057qib7 12045 23 cell cell NN cord-005453-4057qib7 12045 24 transplantation transplantation NN cord-005453-4057qib7 12045 25 ( ( -LRB- cord-005453-4057qib7 12045 26 HSCT HSCT NNP cord-005453-4057qib7 12045 27 ) ) -RRB- cord-005453-4057qib7 12045 28 . . . cord-005453-4057qib7 12046 1 Methods method NNS cord-005453-4057qib7 12046 2 : : : cord-005453-4057qib7 12046 3 Immune immune JJ cord-005453-4057qib7 12046 4 cell cell NN cord-005453-4057qib7 12046 5 subsets subset NNS cord-005453-4057qib7 12046 6 ( ( -LRB- cord-005453-4057qib7 12046 7 CD19 CD19 NNP cord-005453-4057qib7 12046 8 , , , cord-005453-4057qib7 12046 9 CD4 CD4 NNP cord-005453-4057qib7 12046 10 , , , cord-005453-4057qib7 12046 11 CD8 CD8 NNP cord-005453-4057qib7 12046 12 , , , cord-005453-4057qib7 12046 13 CD56 CD56 NNP cord-005453-4057qib7 12046 14 , , , cord-005453-4057qib7 12046 15 CD25+CD127- cd25+cd127- NN cord-005453-4057qib7 12046 16 ) ) -RRB- cord-005453-4057qib7 12046 17 were be VBD cord-005453-4057qib7 12046 18 quantified quantify VBN cord-005453-4057qib7 12046 19 by by IN cord-005453-4057qib7 12046 20 flow flow NN cord-005453-4057qib7 12046 21 cytometry cytometry NN cord-005453-4057qib7 12046 22 . . . cord-005453-4057qib7 12047 1 TREC TREC NNP cord-005453-4057qib7 12047 2 and and CC cord-005453-4057qib7 12047 3 KREC KREC NNP cord-005453-4057qib7 12047 4 were be VBD cord-005453-4057qib7 12047 5 quantified quantify VBN cord-005453-4057qib7 12047 6 simultaneously simultaneously RB cord-005453-4057qib7 12047 7 using use VBG cord-005453-4057qib7 12047 8 droplet droplet NN cord-005453-4057qib7 12047 9 digital digital JJ cord-005453-4057qib7 12047 10 PCR PCR NNP cord-005453-4057qib7 12047 11 ( ( -LRB- cord-005453-4057qib7 12047 12 dPCR dPCR NNP cord-005453-4057qib7 12047 13 ) ) -RRB- cord-005453-4057qib7 12047 14 . . . cord-005453-4057qib7 12048 1 A a DT cord-005453-4057qib7 12048 2 total total NN cord-005453-4057qib7 12048 3 of of IN cord-005453-4057qib7 12048 4 31 31 CD cord-005453-4057qib7 12048 5 patients patient NNS cord-005453-4057qib7 12048 6 were be VBD cord-005453-4057qib7 12048 7 evaluated evaluate VBN cord-005453-4057qib7 12048 8 . . . cord-005453-4057qib7 12049 1 Mean mean JJ cord-005453-4057qib7 12049 2 age age NN cord-005453-4057qib7 12049 3 at at IN cord-005453-4057qib7 12049 4 transplant transplant NN cord-005453-4057qib7 12049 5 was be VBD cord-005453-4057qib7 12049 6 56 56 CD cord-005453-4057qib7 12049 7 years year NNS cord-005453-4057qib7 12050 1 ( ( -LRB- cord-005453-4057qib7 12050 2 range range NN cord-005453-4057qib7 12050 3 : : : cord-005453-4057qib7 12050 4 18 18 CD cord-005453-4057qib7 12050 5 - - SYM cord-005453-4057qib7 12050 6 74 74 CD cord-005453-4057qib7 12050 7 years year NNS cord-005453-4057qib7 12050 8 ) ) -RRB- cord-005453-4057qib7 12051 1 Samples sample NNS cord-005453-4057qib7 12051 2 were be VBD cord-005453-4057qib7 12051 3 obtained obtain VBN cord-005453-4057qib7 12051 4 before before IN cord-005453-4057qib7 12051 5 HSCT HSCT NNP cord-005453-4057qib7 12051 6 and and CC cord-005453-4057qib7 12051 7 at at IN cord-005453-4057qib7 12051 8 day day NN cord-005453-4057qib7 12051 9 30 30 CD cord-005453-4057qib7 12051 10 , , , cord-005453-4057qib7 12051 11 100 100 CD cord-005453-4057qib7 12051 12 and and CC cord-005453-4057qib7 12051 13 365 365 CD cord-005453-4057qib7 12051 14 after after IN cord-005453-4057qib7 12051 15 HSCT HSCT NNP cord-005453-4057qib7 12051 16 . . . cord-005453-4057qib7 12052 1 Results result NNS cord-005453-4057qib7 12052 2 : : : cord-005453-4057qib7 12053 1 Absolute absolute JJ cord-005453-4057qib7 12053 2 numbers number NNS cord-005453-4057qib7 12053 3 of of IN cord-005453-4057qib7 12053 4 CD3 CD3 NNP cord-005453-4057qib7 12053 5 and and CC cord-005453-4057qib7 12053 6 CD19 CD19 NNP cord-005453-4057qib7 12053 7 cells cell NNS cord-005453-4057qib7 12053 8 remained remain VBD cord-005453-4057qib7 12053 9 below below IN cord-005453-4057qib7 12053 10 pre pre JJ cord-005453-4057qib7 12053 11 - - JJ cord-005453-4057qib7 12053 12 transplant transplant JJ cord-005453-4057qib7 12053 13 levels level NNS cord-005453-4057qib7 12053 14 until until IN cord-005453-4057qib7 12053 15 day day NN cord-005453-4057qib7 12053 16 100 100 CD cord-005453-4057qib7 12053 17 , , , cord-005453-4057qib7 12053 18 increasing increase VBG cord-005453-4057qib7 12053 19 further far RBR cord-005453-4057qib7 12053 20 and and CC cord-005453-4057qib7 12053 21 eventually eventually RB cord-005453-4057qib7 12053 22 reaching reach VBG cord-005453-4057qib7 12053 23 pre pre JJ cord-005453-4057qib7 12053 24 - - JJ cord-005453-4057qib7 12053 25 transplant transplant JJ cord-005453-4057qib7 12053 26 levels level NNS cord-005453-4057qib7 12053 27 one one CD cord-005453-4057qib7 12053 28 year year NN cord-005453-4057qib7 12053 29 after after IN cord-005453-4057qib7 12053 30 HSCT HSCT NNP cord-005453-4057qib7 12053 31 . . . cord-005453-4057qib7 12054 1 Absolute absolute JJ cord-005453-4057qib7 12054 2 counts count NNS cord-005453-4057qib7 12054 3 of of IN cord-005453-4057qib7 12054 4 CD4 CD4 NNP cord-005453-4057qib7 12054 5 and and CC cord-005453-4057qib7 12054 6 CD25+CD127-cells CD25+CD127-cells NNP cord-005453-4057qib7 12054 7 remained remain VBD cord-005453-4057qib7 12054 8 below below IN cord-005453-4057qib7 12054 9 pre pre JJ cord-005453-4057qib7 12054 10 - - JJ cord-005453-4057qib7 12054 11 transplant transplant JJ cord-005453-4057qib7 12054 12 levels level NNS cord-005453-4057qib7 12054 13 beyond beyond IN cord-005453-4057qib7 12054 14 one one CD cord-005453-4057qib7 12054 15 year year NN cord-005453-4057qib7 12054 16 after after IN cord-005453-4057qib7 12054 17 HSCT HSCT NNP cord-005453-4057qib7 12054 18 . . . cord-005453-4057qib7 12055 1 CD56 cd56 NN cord-005453-4057qib7 12055 2 cells cell NNS cord-005453-4057qib7 12055 3 were be VBD cord-005453-4057qib7 12055 4 characterized characterize VBN cord-005453-4057qib7 12055 5 by by IN cord-005453-4057qib7 12055 6 fast fast JJ cord-005453-4057qib7 12055 7 reconstitution reconstitution NN cord-005453-4057qib7 12055 8 kinetics kinetics NN cord-005453-4057qib7 12055 9 , , , cord-005453-4057qib7 12055 10 reaching reach VBG cord-005453-4057qib7 12055 11 pre pre JJ cord-005453-4057qib7 12055 12 - - JJ cord-005453-4057qib7 12055 13 transplant transplant JJ cord-005453-4057qib7 12055 14 levels level NNS cord-005453-4057qib7 12055 15 already already RB cord-005453-4057qib7 12055 16 at at IN cord-005453-4057qib7 12055 17 day day NN cord-005453-4057qib7 12055 18 30 30 CD cord-005453-4057qib7 12055 19 . . . cord-005453-4057qib7 12056 1 B b NN cord-005453-4057qib7 12056 2 cells cell NNS cord-005453-4057qib7 12056 3 correlated correlate VBN cord-005453-4057qib7 12056 4 with with IN cord-005453-4057qib7 12056 5 KREC KREC NNP cord-005453-4057qib7 12056 6 levels level NNS cord-005453-4057qib7 12056 7 at at IN cord-005453-4057qib7 12056 8 all all DT cord-005453-4057qib7 12056 9 time time NN cord-005453-4057qib7 12056 10 - - HYPH cord-005453-4057qib7 12056 11 points point NNS cord-005453-4057qib7 12056 12 tested test VBN cord-005453-4057qib7 12056 13 , , , cord-005453-4057qib7 12056 14 whereas whereas IN cord-005453-4057qib7 12056 15 T t NN cord-005453-4057qib7 12056 16 cells cell NNS cord-005453-4057qib7 12056 17 correlated correlate VBN cord-005453-4057qib7 12056 18 with with IN cord-005453-4057qib7 12056 19 TREC TREC NNP cord-005453-4057qib7 12056 20 levels level NNS cord-005453-4057qib7 12056 21 only only RB cord-005453-4057qib7 12056 22 one one CD cord-005453-4057qib7 12056 23 year year NN cord-005453-4057qib7 12056 24 after after IN cord-005453-4057qib7 12056 25 transplantation transplantation NN cord-005453-4057qib7 12056 26 . . . cord-005453-4057qib7 12057 1 When when WRB cord-005453-4057qib7 12057 2 we -PRON- PRP cord-005453-4057qib7 12057 3 compared compare VBD cord-005453-4057qib7 12057 4 cell cell NN cord-005453-4057qib7 12057 5 subsets subset NNS cord-005453-4057qib7 12057 6 , , , cord-005453-4057qib7 12057 7 TREC TREC NNP cord-005453-4057qib7 12057 8 , , , cord-005453-4057qib7 12057 9 KREC KREC NNP cord-005453-4057qib7 12057 10 levels level NNS cord-005453-4057qib7 12057 11 and and CC cord-005453-4057qib7 12057 12 the the DT cord-005453-4057qib7 12057 13 reconstitution reconstitution NN cord-005453-4057qib7 12057 14 kinetics kinetics NN cord-005453-4057qib7 12057 15 thereof thereof RB cord-005453-4057qib7 12057 16 between between IN cord-005453-4057qib7 12057 17 patients patient NNS cord-005453-4057qib7 12057 18 with with IN cord-005453-4057qib7 12057 19 reduced reduce VBN cord-005453-4057qib7 12057 20 intensity intensity NN cord-005453-4057qib7 12057 21 conditioning conditioning NN cord-005453-4057qib7 12057 22 ( ( -LRB- cord-005453-4057qib7 12057 23 n=26 n=26 RB cord-005453-4057qib7 12057 24 ) ) -RRB- cord-005453-4057qib7 12057 25 or or CC cord-005453-4057qib7 12057 26 full full JJ cord-005453-4057qib7 12057 27 conditioning conditioning NN cord-005453-4057qib7 12057 28 ( ( -LRB- cord-005453-4057qib7 12057 29 n=5 n=5 JJ cord-005453-4057qib7 12057 30 ) ) -RRB- cord-005453-4057qib7 12057 31 no no DT cord-005453-4057qib7 12057 32 significant significant JJ cord-005453-4057qib7 12057 33 differences difference NNS cord-005453-4057qib7 12057 34 were be VBD cord-005453-4057qib7 12057 35 observed observe VBN cord-005453-4057qib7 12057 36 . . . cord-005453-4057qib7 12058 1 Patients patient NNS cord-005453-4057qib7 12058 2 with with IN cord-005453-4057qib7 12058 3 pre pre JJ cord-005453-4057qib7 12058 4 - - JJ cord-005453-4057qib7 12058 5 transplant transplant JJ cord-005453-4057qib7 12058 6 TREC TREC NNP cord-005453-4057qib7 12058 7 levels level NNS cord-005453-4057qib7 12058 8 above above IN cord-005453-4057qib7 12058 9 the the DT cord-005453-4057qib7 12058 10 mean mean NN cord-005453-4057qib7 12058 11 ( ( -LRB- cord-005453-4057qib7 12058 12 200 200 CD cord-005453-4057qib7 12058 13 TREC TREC NNP cord-005453-4057qib7 12058 14 copies copy NNS cord-005453-4057qib7 12058 15 / / SYM cord-005453-4057qib7 12058 16 ml ml NN cord-005453-4057qib7 12058 17 blood blood NN cord-005453-4057qib7 12058 18 ) ) -RRB- cord-005453-4057qib7 12058 19 showed show VBD cord-005453-4057qib7 12058 20 higher high JJR cord-005453-4057qib7 12058 21 TREC TREC NNP cord-005453-4057qib7 12058 22 levels level NNS cord-005453-4057qib7 12058 23 and and CC cord-005453-4057qib7 12058 24 a a DT cord-005453-4057qib7 12058 25 faster fast JJR cord-005453-4057qib7 12058 26 T t NN cord-005453-4057qib7 12058 27 - - HYPH cord-005453-4057qib7 12058 28 cell cell NN cord-005453-4057qib7 12058 29 reconstitution reconstitution NN cord-005453-4057qib7 12058 30 after after IN cord-005453-4057qib7 12058 31 HSCT HSCT NNP cord-005453-4057qib7 12058 32 suggesting suggest VBG cord-005453-4057qib7 12058 33 that that IN cord-005453-4057qib7 12058 34 Tcell Tcell NNP cord-005453-4057qib7 12058 35 reconstitution reconstitution NN cord-005453-4057qib7 12058 36 can can MD cord-005453-4057qib7 12058 37 be be VB cord-005453-4057qib7 12058 38 predicted predict VBN cord-005453-4057qib7 12058 39 by by IN cord-005453-4057qib7 12058 40 analysing analyse VBG cord-005453-4057qib7 12058 41 thymic thymic JJ cord-005453-4057qib7 12058 42 functionality functionality NN cord-005453-4057qib7 12058 43 before before IN cord-005453-4057qib7 12058 44 transplantation transplantation NN cord-005453-4057qib7 12058 45 . . . cord-005453-4057qib7 12059 1 Indeed indeed RB cord-005453-4057qib7 12059 2 , , , cord-005453-4057qib7 12059 3 in in IN cord-005453-4057qib7 12059 4 patients patient NNS cord-005453-4057qib7 12059 5 with with IN cord-005453-4057qib7 12059 6 a a DT cord-005453-4057qib7 12059 7 pre pre JJ cord-005453-4057qib7 12059 8 - - JJ cord-005453-4057qib7 12059 9 transplant transplant JJ cord-005453-4057qib7 12059 10 TREC TREC NNP cord-005453-4057qib7 12059 11 above above IN cord-005453-4057qib7 12059 12 200 200 CD cord-005453-4057qib7 12059 13 TREC TREC NNP cord-005453-4057qib7 12059 14 copies/ copies/ XX cord-005453-4057qib7 12060 1 ml ml LS cord-005453-4057qib7 12060 2 blood blood NN cord-005453-4057qib7 12060 3 , , , cord-005453-4057qib7 12060 4 the the DT cord-005453-4057qib7 12060 5 positive positive JJ cord-005453-4057qib7 12060 6 predictive predictive JJ cord-005453-4057qib7 12060 7 value value NN cord-005453-4057qib7 12060 8 for for IN cord-005453-4057qib7 12060 9 an an DT cord-005453-4057qib7 12060 10 efficient efficient JJ cord-005453-4057qib7 12060 11 T t NN cord-005453-4057qib7 12060 12 - - HYPH cord-005453-4057qib7 12060 13 cell cell NN cord-005453-4057qib7 12060 14 reconstitution reconstitution NN cord-005453-4057qib7 12060 15 was be VBD cord-005453-4057qib7 12060 16 0.889 0.889 CD cord-005453-4057qib7 12060 17 ( ( -LRB- cord-005453-4057qib7 12060 18 p=0.012 p=0.012 NNP cord-005453-4057qib7 12060 19 ) ) -RRB- cord-005453-4057qib7 12060 20 . . . cord-005453-4057qib7 12061 1 We -PRON- PRP cord-005453-4057qib7 12061 2 analysed analyse VBD cord-005453-4057qib7 12061 3 the the DT cord-005453-4057qib7 12061 4 recovery recovery NN cord-005453-4057qib7 12061 5 kinetics kinetic NNS cord-005453-4057qib7 12061 6 of of IN cord-005453-4057qib7 12061 7 the the DT cord-005453-4057qib7 12061 8 cell cell NN cord-005453-4057qib7 12061 9 subsets subset NNS cord-005453-4057qib7 12061 10 , , , cord-005453-4057qib7 12061 11 TREC TREC NNP cord-005453-4057qib7 12061 12 and and CC cord-005453-4057qib7 12061 13 KREC KREC NNP cord-005453-4057qib7 12061 14 levels level NNS cord-005453-4057qib7 12061 15 in in IN cord-005453-4057qib7 12061 16 patients patient NNS cord-005453-4057qib7 12061 17 with with IN cord-005453-4057qib7 12061 18 and and CC cord-005453-4057qib7 12061 19 without without IN cord-005453-4057qib7 12061 20 transplant transplant NN cord-005453-4057qib7 12061 21 - - HYPH cord-005453-4057qib7 12061 22 related relate VBN cord-005453-4057qib7 12061 23 complications complication NNS cord-005453-4057qib7 12061 24 . . . cord-005453-4057qib7 12062 1 Patients patient NNS cord-005453-4057qib7 12062 2 with with IN cord-005453-4057qib7 12062 3 either either DT cord-005453-4057qib7 12062 4 acute acute JJ cord-005453-4057qib7 12062 5 graft graft NN cord-005453-4057qib7 12062 6 - - HYPH cord-005453-4057qib7 12062 7 versus versus IN cord-005453-4057qib7 12062 8 - - HYPH cord-005453-4057qib7 12062 9 host host NN cord-005453-4057qib7 12062 10 disease disease NN cord-005453-4057qib7 12062 11 or or CC cord-005453-4057qib7 12062 12 severe severe JJ cord-005453-4057qib7 12062 13 infections infection NNS cord-005453-4057qib7 12062 14 showed show VBD cord-005453-4057qib7 12062 15 a a DT cord-005453-4057qib7 12062 16 slower slow JJR cord-005453-4057qib7 12062 17 TREC trec JJ cord-005453-4057qib7 12062 18 reconstitution reconstitution NN cord-005453-4057qib7 12062 19 when when WRB cord-005453-4057qib7 12062 20 compared compare VBN cord-005453-4057qib7 12062 21 with with IN cord-005453-4057qib7 12062 22 patients patient NNS cord-005453-4057qib7 12062 23 without without IN cord-005453-4057qib7 12062 24 complications complication NNS cord-005453-4057qib7 12062 25 . . . cord-005453-4057qib7 12063 1 Conclusions conclusion NNS cord-005453-4057qib7 12063 2 : : : cord-005453-4057qib7 12064 1 Our -PRON- PRP$ cord-005453-4057qib7 12064 2 data datum NNS cord-005453-4057qib7 12064 3 suggest suggest VBP cord-005453-4057qib7 12064 4 that that IN cord-005453-4057qib7 12064 5 the the DT cord-005453-4057qib7 12064 6 analysis analysis NN cord-005453-4057qib7 12064 7 of of IN cord-005453-4057qib7 12064 8 immune immune JJ cord-005453-4057qib7 12064 9 cell cell NN cord-005453-4057qib7 12064 10 subsets subset NNS cord-005453-4057qib7 12064 11 together together RB cord-005453-4057qib7 12064 12 with with IN cord-005453-4057qib7 12064 13 TREC TREC NNP cord-005453-4057qib7 12064 14 and and CC cord-005453-4057qib7 12064 15 KREC KREC NNP cord-005453-4057qib7 12064 16 quantification quantification NN cord-005453-4057qib7 12064 17 can can MD cord-005453-4057qib7 12064 18 be be VB cord-005453-4057qib7 12064 19 used use VBN cord-005453-4057qib7 12064 20 to to TO cord-005453-4057qib7 12064 21 evaluate evaluate VB cord-005453-4057qib7 12064 22 the the DT cord-005453-4057qib7 12064 23 immune immune JJ cord-005453-4057qib7 12064 24 reconstitution reconstitution NN cord-005453-4057qib7 12064 25 process process NN cord-005453-4057qib7 12064 26 after after IN cord-005453-4057qib7 12064 27 HSCT HSCT NNP cord-005453-4057qib7 12064 28 . . . cord-005453-4057qib7 12065 1 Pre pre JJ cord-005453-4057qib7 12065 2 - - JJ cord-005453-4057qib7 12065 3 transplant transplant JJ cord-005453-4057qib7 12065 4 TREC TREC NNP cord-005453-4057qib7 12065 5 levels level NNS cord-005453-4057qib7 12065 6 allow allow VBP cord-005453-4057qib7 12065 7 T t NN cord-005453-4057qib7 12065 8 - - HYPH cord-005453-4057qib7 12065 9 cell cell NN cord-005453-4057qib7 12065 10 reconstitution reconstitution NN cord-005453-4057qib7 12065 11 efficiency efficiency NN cord-005453-4057qib7 12065 12 prediction prediction NN cord-005453-4057qib7 12065 13 after after IN cord-005453-4057qib7 12065 14 HSCT HSCT NNP cord-005453-4057qib7 12065 15 . . . cord-005453-4057qib7 12066 1 Disclosure disclosure NN cord-005453-4057qib7 12066 2 : : : cord-005453-4057qib7 12066 3 Nothing nothing NN cord-005453-4057qib7 12066 4 to to TO cord-005453-4057qib7 12066 5 declare declare VB cord-005453-4057qib7 12066 6 Background background NN cord-005453-4057qib7 12066 7 : : : cord-005453-4057qib7 12066 8 Falling fall VBG cord-005453-4057qib7 12066 9 donor donor NN cord-005453-4057qib7 12066 10 / / SYM cord-005453-4057qib7 12066 11 mixed mix VBN cord-005453-4057qib7 12066 12 chimerism chimerism NN cord-005453-4057qib7 12066 13 after after IN cord-005453-4057qib7 12066 14 allogeneic allogeneic NN cord-005453-4057qib7 12066 15 haematopoetic haematopoetic JJ cord-005453-4057qib7 12066 16 stem stem NN cord-005453-4057qib7 12066 17 cell cell NN cord-005453-4057qib7 12066 18 transplant transplant NN cord-005453-4057qib7 12066 19 ( ( -LRB- cord-005453-4057qib7 12066 20 SCT SCT NNP cord-005453-4057qib7 12066 21 ) ) -RRB- cord-005453-4057qib7 12066 22 is be VBZ cord-005453-4057qib7 12066 23 associated associate VBN cord-005453-4057qib7 12066 24 with with IN cord-005453-4057qib7 12066 25 an an DT cord-005453-4057qib7 12066 26 increased increase VBN cord-005453-4057qib7 12066 27 risk risk NN cord-005453-4057qib7 12066 28 of of IN cord-005453-4057qib7 12066 29 relapse relapse NN cord-005453-4057qib7 12066 30 and and CC cord-005453-4057qib7 12066 31 the the DT cord-005453-4057qib7 12066 32 potential potential NN cord-005453-4057qib7 12066 33 for for IN cord-005453-4057qib7 12066 34 graft graft NN cord-005453-4057qib7 12066 35 rejection rejection NN cord-005453-4057qib7 12066 36 . . . cord-005453-4057qib7 12067 1 Donor donor NN cord-005453-4057qib7 12067 2 lymphocyte lymphocyte NN cord-005453-4057qib7 12067 3 infusions infusion NNS cord-005453-4057qib7 12067 4 ( ( -LRB- cord-005453-4057qib7 12067 5 DLI DLI NNP cord-005453-4057qib7 12067 6 ) ) -RRB- cord-005453-4057qib7 12067 7 are be VBP cord-005453-4057qib7 12067 8 often often RB cord-005453-4057qib7 12067 9 administered administer VBN cord-005453-4057qib7 12067 10 in in IN cord-005453-4057qib7 12067 11 patients patient NNS cord-005453-4057qib7 12067 12 with with IN cord-005453-4057qib7 12067 13 mixed mixed JJ cord-005453-4057qib7 12067 14 chimerism chimerism NN cord-005453-4057qib7 12067 15 to to TO cord-005453-4057qib7 12067 16 achieve achieve VB cord-005453-4057qib7 12067 17 full full JJ cord-005453-4057qib7 12067 18 donor donor NN cord-005453-4057qib7 12067 19 chimerism chimerism NN cord-005453-4057qib7 12067 20 but but CC cord-005453-4057qib7 12067 21 there there EX cord-005453-4057qib7 12067 22 is be VBZ cord-005453-4057qib7 12067 23 little little JJ cord-005453-4057qib7 12067 24 data datum NNS cord-005453-4057qib7 12067 25 on on IN cord-005453-4057qib7 12067 26 long long JJ cord-005453-4057qib7 12067 27 term term NN cord-005453-4057qib7 12067 28 outcomes outcome NNS cord-005453-4057qib7 12067 29 for for IN cord-005453-4057qib7 12067 30 DLI DLI NNP cord-005453-4057qib7 12067 31 given give VBN cord-005453-4057qib7 12067 32 for for IN cord-005453-4057qib7 12067 33 persistent persistent JJ cord-005453-4057qib7 12067 34 mixed mixed JJ cord-005453-4057qib7 12067 35 chimerism chimerism NN cord-005453-4057qib7 12067 36 . . . cord-005453-4057qib7 12068 1 Methods method NNS cord-005453-4057qib7 12068 2 : : : cord-005453-4057qib7 12069 1 A a DT cord-005453-4057qib7 12069 2 retrospective retrospective JJ cord-005453-4057qib7 12069 3 analysis analysis NN cord-005453-4057qib7 12069 4 of of IN cord-005453-4057qib7 12069 5 all all DT cord-005453-4057qib7 12069 6 patients patient NNS cord-005453-4057qib7 12069 7 administered administer VBD cord-005453-4057qib7 12069 8 DLI DLI NNP cord-005453-4057qib7 12069 9 for for IN cord-005453-4057qib7 12069 10 mixed mixed JJ cord-005453-4057qib7 12069 11 chimerism chimerism NN cord-005453-4057qib7 12069 12 between between IN cord-005453-4057qib7 12069 13 2008 2008 CD cord-005453-4057qib7 12069 14 to to IN cord-005453-4057qib7 12069 15 January January NNP cord-005453-4057qib7 12069 16 2017 2017 CD cord-005453-4057qib7 12069 17 was be VBD cord-005453-4057qib7 12069 18 performed perform VBN cord-005453-4057qib7 12069 19 . . . cord-005453-4057qib7 12070 1 All all DT cord-005453-4057qib7 12070 2 patients patient NNS cord-005453-4057qib7 12070 3 were be VBD cord-005453-4057qib7 12070 4 transplanted transplant VBN cord-005453-4057qib7 12070 5 at at IN cord-005453-4057qib7 12070 6 the the DT cord-005453-4057qib7 12070 7 University University NNP cord-005453-4057qib7 12070 8 Hospital Hospital NNP cord-005453-4057qib7 12070 9 of of IN cord-005453-4057qib7 12070 10 Wales Wales NNP cord-005453-4057qib7 12070 11 within within IN cord-005453-4057qib7 12070 12 the the DT cord-005453-4057qib7 12070 13 South South NNP cord-005453-4057qib7 12070 14 Wales Wales NNP cord-005453-4057qib7 12070 15 Blood Blood NNP cord-005453-4057qib7 12070 16 and and CC cord-005453-4057qib7 12070 17 Marrow Marrow NNP cord-005453-4057qib7 12070 18 Transplant Transplant NNP cord-005453-4057qib7 12070 19 ( ( -LRB- cord-005453-4057qib7 12070 20 SWBMT SWBMT NNP cord-005453-4057qib7 12070 21 ) ) -RRB- cord-005453-4057qib7 12070 22 Programme Programme NNP cord-005453-4057qib7 12070 23 . . . cord-005453-4057qib7 12071 1 Patients patient NNS cord-005453-4057qib7 12071 2 were be VBD cord-005453-4057qib7 12071 3 identified identify VBN cord-005453-4057qib7 12071 4 by by IN cord-005453-4057qib7 12071 5 the the DT cord-005453-4057qib7 12071 6 SWBMT SWBMT NNP cord-005453-4057qib7 12071 7 database database NN cord-005453-4057qib7 12071 8 and and CC cord-005453-4057qib7 12071 9 additional additional JJ cord-005453-4057qib7 12071 10 outcome outcome NN cord-005453-4057qib7 12071 11 data datum NNS cord-005453-4057qib7 12071 12 gathered gather VBN cord-005453-4057qib7 12071 13 by by IN cord-005453-4057qib7 12071 14 review review NN cord-005453-4057qib7 12071 15 of of IN cord-005453-4057qib7 12071 16 patients patient NNS cord-005453-4057qib7 12071 17 ' ' POS cord-005453-4057qib7 12071 18 medical medical JJ cord-005453-4057qib7 12071 19 records record NNS cord-005453-4057qib7 12071 20 . . . cord-005453-4057qib7 12072 1 Results result NNS cord-005453-4057qib7 12072 2 : : : cord-005453-4057qib7 12073 1 58 58 CD cord-005453-4057qib7 12073 2 patients patient NNS cord-005453-4057qib7 12073 3 were be VBD cord-005453-4057qib7 12073 4 treated treat VBN cord-005453-4057qib7 12073 5 with with IN cord-005453-4057qib7 12073 6 111 111 CD cord-005453-4057qib7 12073 7 donor donor NN cord-005453-4057qib7 12073 8 lymphocyte lymphocyte NN cord-005453-4057qib7 12073 9 infusions infusion NNS cord-005453-4057qib7 12073 10 between between IN cord-005453-4057qib7 12073 11 2008 2008 CD cord-005453-4057qib7 12073 12 and and CC cord-005453-4057qib7 12073 13 January January NNP cord-005453-4057qib7 12073 14 2017 2017 CD cord-005453-4057qib7 12073 15 . . . cord-005453-4057qib7 12074 1 Thirty thirty CD cord-005453-4057qib7 12074 2 one one CD cord-005453-4057qib7 12074 3 patients patient NNS cord-005453-4057qib7 12074 4 treated treat VBN cord-005453-4057qib7 12074 5 for for IN cord-005453-4057qib7 12074 6 relapse relapse NN cord-005453-4057qib7 12074 7 ( ( -LRB- cord-005453-4057qib7 12074 8 with with IN cord-005453-4057qib7 12074 9 or or CC cord-005453-4057qib7 12074 10 without without IN cord-005453-4057qib7 12074 11 mixed mixed JJ cord-005453-4057qib7 12074 12 chimerism chimerism NN cord-005453-4057qib7 12074 13 ) ) -RRB- cord-005453-4057qib7 12074 14 were be VBD cord-005453-4057qib7 12074 15 excluded exclude VBN cord-005453-4057qib7 12074 16 as as IN cord-005453-4057qib7 12074 17 was be VBD cord-005453-4057qib7 12074 18 a a DT cord-005453-4057qib7 12074 19 further further JJ cord-005453-4057qib7 12074 20 patient patient NN cord-005453-4057qib7 12074 21 with with IN cord-005453-4057qib7 12074 22 a a DT cord-005453-4057qib7 12074 23 mismatched mismatched JJ cord-005453-4057qib7 12074 24 donor donor NN cord-005453-4057qib7 12074 25 . . . cord-005453-4057qib7 12075 1 The the DT cord-005453-4057qib7 12075 2 rest rest NN cord-005453-4057qib7 12075 3 were be VBD cord-005453-4057qib7 12075 4 10/10 10/10 CD cord-005453-4057qib7 12075 5 match match NN cord-005453-4057qib7 12075 6 . . . cord-005453-4057qib7 12076 1 Twenty twenty CD cord-005453-4057qib7 12076 2 six six CD cord-005453-4057qib7 12076 3 patients patient NNS cord-005453-4057qib7 12076 4 received receive VBD cord-005453-4057qib7 12076 5 a a DT cord-005453-4057qib7 12076 6 total total NN cord-005453-4057qib7 12076 7 of of IN cord-005453-4057qib7 12076 8 54 54 CD cord-005453-4057qib7 12076 9 donor donor NN cord-005453-4057qib7 12076 10 lymphocyte lymphocyte NN cord-005453-4057qib7 12076 11 infusions infusion NNS cord-005453-4057qib7 12076 12 for for IN cord-005453-4057qib7 12076 13 mixed mixed JJ cord-005453-4057qib7 12076 14 chimerism chimerism NN cord-005453-4057qib7 12076 15 alone alone RB cord-005453-4057qib7 12076 16 . . . cord-005453-4057qib7 12077 1 The the DT cord-005453-4057qib7 12077 2 median median JJ cord-005453-4057qib7 12077 3 age age NN cord-005453-4057qib7 12077 4 was be VBD cord-005453-4057qib7 12077 5 63 63 CD cord-005453-4057qib7 12077 6 years year NNS cord-005453-4057qib7 12078 1 ( ( -LRB- cord-005453-4057qib7 12078 2 range range NN cord-005453-4057qib7 12078 3 : : : cord-005453-4057qib7 12078 4 27 27 CD cord-005453-4057qib7 12078 5 - - SYM cord-005453-4057qib7 12078 6 71 71 CD cord-005453-4057qib7 12078 7 ) ) -RRB- cord-005453-4057qib7 12078 8 with with IN cord-005453-4057qib7 12078 9 65 65 CD cord-005453-4057qib7 12078 10 % % NN cord-005453-4057qib7 12078 11 women woman NNS cord-005453-4057qib7 12078 12 . . . cord-005453-4057qib7 12079 1 Fourteen fourteen CD cord-005453-4057qib7 12079 2 ( ( -LRB- cord-005453-4057qib7 12079 3 54 54 CD cord-005453-4057qib7 12079 4 % % NN cord-005453-4057qib7 12079 5 ) ) -RRB- cord-005453-4057qib7 12079 6 of of IN cord-005453-4057qib7 12079 7 the the DT cord-005453-4057qib7 12079 8 patients patient NNS cord-005453-4057qib7 12079 9 had have VBD cord-005453-4057qib7 12079 10 sibling sibling NN cord-005453-4057qib7 12079 11 donor donor NN cord-005453-4057qib7 12079 12 transplants transplant NNS cord-005453-4057qib7 12079 13 and and CC cord-005453-4057qib7 12079 14 twelve twelve CD cord-005453-4057qib7 12079 15 ( ( -LRB- cord-005453-4057qib7 12079 16 46 46 CD cord-005453-4057qib7 12079 17 % % NN cord-005453-4057qib7 12079 18 ) ) -RRB- cord-005453-4057qib7 12079 19 from from IN cord-005453-4057qib7 12079 20 matched match VBN cord-005453-4057qib7 12079 21 unrelated unrelated JJ cord-005453-4057qib7 12079 22 donors donor NNS cord-005453-4057qib7 12079 23 . . . cord-005453-4057qib7 12080 1 Indications indication NNS cord-005453-4057qib7 12080 2 for for IN cord-005453-4057qib7 12080 3 transplant transplant NN cord-005453-4057qib7 12080 4 were be VBD cord-005453-4057qib7 12080 5 : : : cord-005453-4057qib7 12080 6 for for IN cord-005453-4057qib7 12080 7 AML AML NNP cord-005453-4057qib7 12080 8 or or CC cord-005453-4057qib7 12080 9 sAML saml NN cord-005453-4057qib7 12081 1 ( ( -LRB- cord-005453-4057qib7 12081 2 n=16 n=16 NNP cord-005453-4057qib7 12081 3 ) ) -RRB- cord-005453-4057qib7 12081 4 , , , cord-005453-4057qib7 12081 5 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 12081 6 ( ( -LRB- cord-005453-4057qib7 12081 7 n=4 n=4 NNP cord-005453-4057qib7 12081 8 ) ) -RRB- cord-005453-4057qib7 12081 9 , , , cord-005453-4057qib7 12081 10 MDS MDS NNP cord-005453-4057qib7 12081 11 ( ( -LRB- cord-005453-4057qib7 12081 12 n=3 n=3 NN cord-005453-4057qib7 12081 13 ) ) -RRB- cord-005453-4057qib7 12081 14 , , , cord-005453-4057qib7 12081 15 Hodgkin Hodgkin NNP cord-005453-4057qib7 12081 16 lymphoma lymphoma NN cord-005453-4057qib7 12081 17 ( ( -LRB- cord-005453-4057qib7 12081 18 n=1 n=1 CD cord-005453-4057qib7 12081 19 ) ) -RRB- cord-005453-4057qib7 12081 20 , , , cord-005453-4057qib7 12081 21 non non JJ cord-005453-4057qib7 12081 22 - - JJ cord-005453-4057qib7 12081 23 Hodgkin Hodgkin NNP cord-005453-4057qib7 12081 24 lymphoma lymphoma NN cord-005453-4057qib7 12081 25 ( ( -LRB- cord-005453-4057qib7 12081 26 n=1 n=1 FW cord-005453-4057qib7 12081 27 ) ) -RRB- cord-005453-4057qib7 12081 28 and and CC cord-005453-4057qib7 12081 29 ALL all DT cord-005453-4057qib7 12081 30 ( ( -LRB- cord-005453-4057qib7 12081 31 n=1 n=1 JJ cord-005453-4057qib7 12081 32 ) ) -RRB- cord-005453-4057qib7 12081 33 . . . cord-005453-4057qib7 12082 1 Escalating escalate VBG cord-005453-4057qib7 12082 2 doses dose NNS cord-005453-4057qib7 12082 3 of of IN cord-005453-4057qib7 12082 4 donor donor NN cord-005453-4057qib7 12082 5 CD3 cd3 NN cord-005453-4057qib7 12083 1 + + CC cord-005453-4057qib7 12083 2 T t NN cord-005453-4057qib7 12083 3 cells cell NNS cord-005453-4057qib7 12083 4 were be VBD cord-005453-4057qib7 12083 5 administered administer VBN cord-005453-4057qib7 12083 6 commencing commence VBG cord-005453-4057qib7 12083 7 at at IN cord-005453-4057qib7 12083 8 5×10 5×10 CD cord-005453-4057qib7 12083 9 5 5 CD cord-005453-4057qib7 12083 10 /kg /kg NN cord-005453-4057qib7 12083 11 to to IN cord-005453-4057qib7 12083 12 5×10 5×10 CD cord-005453-4057qib7 12083 13 6 6 CD cord-005453-4057qib7 12083 14 /kg /kg . cord-005453-4057qib7 12083 15 then then RB cord-005453-4057qib7 12083 16 increased increase VBN cord-005453-4057qib7 12083 17 at at IN cord-005453-4057qib7 12083 18 half half JJ cord-005453-4057qib7 12083 19 log log NN cord-005453-4057qib7 12083 20 increments increment NNS cord-005453-4057qib7 12083 21 according accord VBG cord-005453-4057qib7 12083 22 to to IN cord-005453-4057qib7 12083 23 chimerism chimerism NN cord-005453-4057qib7 12083 24 results result NNS cord-005453-4057qib7 12083 25 until until IN cord-005453-4057qib7 12083 26 full full JJ cord-005453-4057qib7 12083 27 donor donor NN cord-005453-4057qib7 12083 28 chimerism chimerism NN cord-005453-4057qib7 12083 29 was be VBD cord-005453-4057qib7 12083 30 achieved achieve VBN cord-005453-4057qib7 12083 31 . . . cord-005453-4057qib7 12084 1 The the DT cord-005453-4057qib7 12084 2 median median JJ cord-005453-4057qib7 12084 3 number number NN cord-005453-4057qib7 12084 4 of of IN cord-005453-4057qib7 12084 5 doses dose NNS cord-005453-4057qib7 12084 6 administered administer VBN cord-005453-4057qib7 12084 7 was be VBD cord-005453-4057qib7 12084 8 2 2 CD cord-005453-4057qib7 12085 1 ( ( -LRB- cord-005453-4057qib7 12085 2 range range NNP cord-005453-4057qib7 12085 3 1 1 CD cord-005453-4057qib7 12085 4 - - SYM cord-005453-4057qib7 12085 5 5 5 CD cord-005453-4057qib7 12085 6 ) ) -RRB- cord-005453-4057qib7 12085 7 . . . cord-005453-4057qib7 12086 1 The the DT cord-005453-4057qib7 12086 2 median median JJ cord-005453-4057qib7 12086 3 interval interval NN cord-005453-4057qib7 12086 4 was be VBD cord-005453-4057qib7 12086 5 94 94 CD cord-005453-4057qib7 12086 6 days day NNS cord-005453-4057qib7 12086 7 ( ( -LRB- cord-005453-4057qib7 12086 8 range range VBP cord-005453-4057qib7 12086 9 48 48 CD cord-005453-4057qib7 12086 10 - - SYM cord-005453-4057qib7 12086 11 408 408 CD cord-005453-4057qib7 12086 12 ) ) -RRB- cord-005453-4057qib7 12086 13 . . . cord-005453-4057qib7 12087 1 The the DT cord-005453-4057qib7 12087 2 median median JJ cord-005453-4057qib7 12087 3 dose dose NN cord-005453-4057qib7 12087 4 was be VBD cord-005453-4057qib7 12087 5 1×10 1×10 CD cord-005453-4057qib7 12087 6 6 6 CD cord-005453-4057qib7 12087 7 / / SYM cord-005453-4057qib7 12087 8 kg kg NN cord-005453-4057qib7 12088 1 ( ( -LRB- cord-005453-4057qib7 12088 2 range range VBP cord-005453-4057qib7 12088 3 5×10 5×10 CD cord-005453-4057qib7 12088 4 5 5 CD cord-005453-4057qib7 12088 5 -6×10 -6×10 NNP cord-005453-4057qib7 12088 6 7 7 CD cord-005453-4057qib7 12088 7 ) ) -RRB- cord-005453-4057qib7 12088 8 . . . cord-005453-4057qib7 12089 1 Seventeen seventeen CD cord-005453-4057qib7 12089 2 patients patient NNS cord-005453-4057qib7 12089 3 ( ( -LRB- cord-005453-4057qib7 12089 4 65 65 CD cord-005453-4057qib7 12089 5 % % NN cord-005453-4057qib7 12089 6 ) ) -RRB- cord-005453-4057qib7 12089 7 achieved achieve VBN cord-005453-4057qib7 12089 8 full full JJ cord-005453-4057qib7 12089 9 donor donor NN cord-005453-4057qib7 12089 10 chimerism chimerism NN cord-005453-4057qib7 12089 11 and and CC cord-005453-4057qib7 12089 12 remained remain VBD cord-005453-4057qib7 12089 13 so so RB cord-005453-4057qib7 12089 14 until until IN cord-005453-4057qib7 12089 15 most most JJS cord-005453-4057qib7 12089 16 recent recent JJ cord-005453-4057qib7 12089 17 follow follow VBP cord-005453-4057qib7 12089 18 up up RP cord-005453-4057qib7 12089 19 ( ( -LRB- cord-005453-4057qib7 12089 20 median median NN cord-005453-4057qib7 12089 21 25 25 CD cord-005453-4057qib7 12089 22 months month NNS cord-005453-4057qib7 12089 23 , , , cord-005453-4057qib7 12090 1 range range NNP cord-005453-4057qib7 12090 2 12 12 CD cord-005453-4057qib7 12090 3 - - SYM cord-005453-4057qib7 12090 4 64 64 CD cord-005453-4057qib7 12090 5 ) ) -RRB- cord-005453-4057qib7 12090 6 . . . cord-005453-4057qib7 12091 1 One one CD cord-005453-4057qib7 12091 2 patient patient NN cord-005453-4057qib7 12091 3 continued continue VBD cord-005453-4057qib7 12091 4 to to TO cord-005453-4057qib7 12091 5 receive receive VB cord-005453-4057qib7 12091 6 DLI DLI NNP cord-005453-4057qib7 12091 7 after after IN cord-005453-4057qib7 12091 8 the the DT cord-005453-4057qib7 12091 9 study study NN cord-005453-4057qib7 12091 10 period period NN cord-005453-4057qib7 12091 11 and and CC cord-005453-4057qib7 12091 12 later later RB cord-005453-4057qib7 12091 13 reverted revert VBN cord-005453-4057qib7 12091 14 to to IN cord-005453-4057qib7 12091 15 full full JJ cord-005453-4057qib7 12091 16 donor donor NN cord-005453-4057qib7 12091 17 . . . cord-005453-4057qib7 12092 1 Two two CD cord-005453-4057qib7 12092 2 patients patient NNS cord-005453-4057qib7 12092 3 had have VBD cord-005453-4057qib7 12092 4 ongoing ongoing JJ cord-005453-4057qib7 12092 5 mixed mixed JJ cord-005453-4057qib7 12092 6 chimerism chimerism NN cord-005453-4057qib7 12092 7 with with IN cord-005453-4057qib7 12092 8 no no DT cord-005453-4057qib7 12092 9 evidence evidence NN cord-005453-4057qib7 12092 10 of of IN cord-005453-4057qib7 12092 11 relapse relapse NN cord-005453-4057qib7 12092 12 . . . cord-005453-4057qib7 12093 1 Two two CD cord-005453-4057qib7 12093 2 patients patient NNS cord-005453-4057qib7 12093 3 relapsed relapse VBD cord-005453-4057qib7 12093 4 ; ; : cord-005453-4057qib7 12093 5 one one CD cord-005453-4057qib7 12093 6 of of IN cord-005453-4057qib7 12093 7 whom whom WP cord-005453-4057qib7 12093 8 later later RB cord-005453-4057qib7 12093 9 achieved achieve VBD cord-005453-4057qib7 12093 10 remission remission NN cord-005453-4057qib7 12093 11 . . . cord-005453-4057qib7 12094 1 There there EX cord-005453-4057qib7 12094 2 were be VBD cord-005453-4057qib7 12094 3 six six CD cord-005453-4057qib7 12094 4 cases case NNS cord-005453-4057qib7 12094 5 of of IN cord-005453-4057qib7 12094 6 GvHD GvHD NNP cord-005453-4057qib7 12094 7 ; ; : cord-005453-4057qib7 12094 8 acute acute JJ cord-005453-4057qib7 12094 9 GvHD GvHD NNP cord-005453-4057qib7 12094 10 ( ( -LRB- cord-005453-4057qib7 12095 1 grade grade NN cord-005453-4057qib7 12095 2 II II NNP cord-005453-4057qib7 12095 3 n=2 n=2 NNS cord-005453-4057qib7 12095 4 , , , cord-005453-4057qib7 12095 5 grade grade NN cord-005453-4057qib7 12095 6 III iii CD cord-005453-4057qib7 12095 7 n=1 n=1 NN cord-005453-4057qib7 12095 8 ) ) -RRB- cord-005453-4057qib7 12095 9 and and CC cord-005453-4057qib7 12095 10 2 2 CD cord-005453-4057qib7 12095 11 cases case NNS cord-005453-4057qib7 12095 12 of of IN cord-005453-4057qib7 12095 13 chronic chronic JJ cord-005453-4057qib7 12095 14 extensive extensive JJ cord-005453-4057qib7 12095 15 GvHD gvhd NN cord-005453-4057qib7 12095 16 . . . cord-005453-4057qib7 12096 1 One one CD cord-005453-4057qib7 12096 2 patient patient NN cord-005453-4057qib7 12096 3 had have VBD cord-005453-4057qib7 12096 4 GvHD GvHD NNP cord-005453-4057qib7 12096 5 features feature NNS cord-005453-4057qib7 12096 6 consistent consistent JJ cord-005453-4057qib7 12096 7 with with IN cord-005453-4057qib7 12096 8 overlap overlap NN cord-005453-4057qib7 12096 9 syndrome syndrome NN cord-005453-4057qib7 12096 10 . . . cord-005453-4057qib7 12097 1 A a DT cord-005453-4057qib7 12097 2 total total NN cord-005453-4057qib7 12097 3 of of IN cord-005453-4057qib7 12097 4 five five CD cord-005453-4057qib7 12097 5 patients patient NNS cord-005453-4057qib7 12097 6 died die VBD cord-005453-4057qib7 12097 7 , , , cord-005453-4057qib7 12097 8 four four CD cord-005453-4057qib7 12097 9 due due JJ cord-005453-4057qib7 12097 10 to to IN cord-005453-4057qib7 12097 11 infection infection NN cord-005453-4057qib7 12097 12 ( ( -LRB- cord-005453-4057qib7 12097 13 one one CD cord-005453-4057qib7 12097 14 in in IN cord-005453-4057qib7 12097 15 a a DT cord-005453-4057qib7 12097 16 patient patient NN cord-005453-4057qib7 12097 17 with with IN cord-005453-4057qib7 12097 18 GvHD GvHD NNP cord-005453-4057qib7 12097 19 ) ) -RRB- cord-005453-4057qib7 12097 20 and and CC cord-005453-4057qib7 12097 21 one one CD cord-005453-4057qib7 12097 22 due due IN cord-005453-4057qib7 12097 23 to to IN cord-005453-4057qib7 12097 24 cardiac cardiac JJ cord-005453-4057qib7 12097 25 toxicity toxicity NN cord-005453-4057qib7 12097 26 from from IN cord-005453-4057qib7 12097 27 previous previous JJ cord-005453-4057qib7 12097 28 treatment treatment NN cord-005453-4057qib7 12097 29 ( ( -LRB- cord-005453-4057qib7 12097 30 confirmed confirm VBN cord-005453-4057qib7 12097 31 on on IN cord-005453-4057qib7 12097 32 post post JJ cord-005453-4057qib7 12097 33 - - JJ cord-005453-4057qib7 12097 34 mortem mortem JJ cord-005453-4057qib7 12097 35 ) ) -RRB- cord-005453-4057qib7 12097 36 . . . cord-005453-4057qib7 12098 1 Conclusions conclusion NNS cord-005453-4057qib7 12098 2 : : : cord-005453-4057qib7 12099 1 The the DT cord-005453-4057qib7 12099 2 results result NNS cord-005453-4057qib7 12099 3 of of IN cord-005453-4057qib7 12099 4 our -PRON- PRP$ cord-005453-4057qib7 12099 5 single single JJ cord-005453-4057qib7 12099 6 centre centre NN cord-005453-4057qib7 12099 7 study study NN cord-005453-4057qib7 12099 8 help help NN cord-005453-4057qib7 12099 9 reinforce reinforce VB cord-005453-4057qib7 12099 10 the the DT cord-005453-4057qib7 12099 11 evidence evidence NN cord-005453-4057qib7 12099 12 for for IN cord-005453-4057qib7 12099 13 DLI DLI NNP cord-005453-4057qib7 12099 14 in in IN cord-005453-4057qib7 12099 15 establishing establish VBG cord-005453-4057qib7 12099 16 full full JJ cord-005453-4057qib7 12099 17 donor donor NN cord-005453-4057qib7 12099 18 chimerism chimerism NN cord-005453-4057qib7 12099 19 when when WRB cord-005453-4057qib7 12099 20 mixed mixed JJ cord-005453-4057qib7 12099 21 chimerism chimerism NN cord-005453-4057qib7 12099 22 is be VBZ cord-005453-4057qib7 12099 23 detected detect VBN cord-005453-4057qib7 12099 24 in in IN cord-005453-4057qib7 12099 25 the the DT cord-005453-4057qib7 12099 26 absence absence NN cord-005453-4057qib7 12099 27 of of IN cord-005453-4057qib7 12099 28 relapse relapse NN cord-005453-4057qib7 12099 29 . . . cord-005453-4057qib7 12100 1 Incremental incremental JJ cord-005453-4057qib7 12100 2 DLI DLI NNP cord-005453-4057qib7 12100 3 dosing dosing NN cord-005453-4057qib7 12100 4 is be VBZ cord-005453-4057qib7 12100 5 an an DT cord-005453-4057qib7 12100 6 effective effective JJ cord-005453-4057qib7 12100 7 strategy strategy NN cord-005453-4057qib7 12100 8 and and CC cord-005453-4057qib7 12100 9 associated associate VBN cord-005453-4057qib7 12100 10 with with IN cord-005453-4057qib7 12100 11 a a DT cord-005453-4057qib7 12100 12 low low JJ cord-005453-4057qib7 12100 13 relapse relapse NN cord-005453-4057qib7 12100 14 rate rate NN cord-005453-4057qib7 12100 15 . . . cord-005453-4057qib7 12101 1 Caution caution NN cord-005453-4057qib7 12101 2 should should MD cord-005453-4057qib7 12101 3 still still RB cord-005453-4057qib7 12101 4 be be VB cord-005453-4057qib7 12101 5 given give VBN cord-005453-4057qib7 12101 6 to to IN cord-005453-4057qib7 12101 7 the the DT cord-005453-4057qib7 12101 8 risk risk NN cord-005453-4057qib7 12101 9 of of IN cord-005453-4057qib7 12101 10 GvHD GvHD NNP cord-005453-4057qib7 12101 11 following follow VBG cord-005453-4057qib7 12101 12 DLI DLI NNP cord-005453-4057qib7 12101 13 , , , cord-005453-4057qib7 12101 14 however however RB cord-005453-4057qib7 12101 15 the the DT cord-005453-4057qib7 12101 16 risk risk NN cord-005453-4057qib7 12101 17 appears appear VBZ cord-005453-4057qib7 12101 18 to to TO cord-005453-4057qib7 12101 19 be be VB cord-005453-4057qib7 12101 20 low low JJ cord-005453-4057qib7 12101 21 in in IN cord-005453-4057qib7 12101 22 this this DT cord-005453-4057qib7 12101 23 study study NN cord-005453-4057qib7 12101 24 . . . cord-005453-4057qib7 12102 1 Larger large JJR cord-005453-4057qib7 12102 2 prospective prospective JJ cord-005453-4057qib7 12102 3 studies study NNS cord-005453-4057qib7 12102 4 are be VBP cord-005453-4057qib7 12102 5 ongoing ongoing JJ cord-005453-4057qib7 12102 6 to to TO cord-005453-4057qib7 12102 7 address address VB cord-005453-4057qib7 12102 8 the the DT cord-005453-4057qib7 12102 9 optimal optimal JJ cord-005453-4057qib7 12102 10 dosing dosing NN cord-005453-4057qib7 12102 11 strategy strategy NN cord-005453-4057qib7 12102 12 for for IN cord-005453-4057qib7 12102 13 DLI DLI NNP cord-005453-4057qib7 12102 14 post post NN cord-005453-4057qib7 12102 15 - - NN cord-005453-4057qib7 12102 16 transplant transplant NN cord-005453-4057qib7 12102 17 . . . cord-005453-4057qib7 12103 1 Disclosure disclosure NN cord-005453-4057qib7 12103 2 : : : cord-005453-4057qib7 12103 3 Nothing nothing NN cord-005453-4057qib7 12103 4 to to TO cord-005453-4057qib7 12103 5 declare declare VB cord-005453-4057qib7 12103 6 Hypomethylating Hypomethylating NNP cord-005453-4057qib7 12103 7 agents agent NNS cord-005453-4057qib7 12103 8 for for IN cord-005453-4057qib7 12103 9 the the DT cord-005453-4057qib7 12103 10 treatment treatment NN cord-005453-4057qib7 12103 11 of of IN cord-005453-4057qib7 12103 12 relapsed relapsed JJ cord-005453-4057qib7 12103 13 acute acute JJ cord-005453-4057qib7 12103 14 myeloid myeloid NN cord-005453-4057qib7 12103 15 leukemia leukemia NN cord-005453-4057qib7 12103 16 after after IN cord-005453-4057qib7 12103 17 allogeneic allogeneic NN cord-005453-4057qib7 12103 18 blood blood NN cord-005453-4057qib7 12103 19 stem stem NN cord-005453-4057qib7 12103 20 cell cell NN cord-005453-4057qib7 12103 21 transplantation transplantation NN cord-005453-4057qib7 12103 22 : : : cord-005453-4057qib7 12103 23 A a DT cord-005453-4057qib7 12103 24 single single JJ cord-005453-4057qib7 12103 25 center center NN cord-005453-4057qib7 12103 26 experience experience NN cord-005453-4057qib7 12103 27 Mariarita Mariarita NNP cord-005453-4057qib7 12103 28 Sciume Sciume NNP cord-005453-4057qib7 12103 29 1 1 CD cord-005453-4057qib7 12103 30 , , , cord-005453-4057qib7 12103 31 Giorgia Giorgia NNP cord-005453-4057qib7 12103 32 Saporiti Saporiti NNP cord-005453-4057qib7 12103 33 1 1 CD cord-005453-4057qib7 12103 34 , , , cord-005453-4057qib7 12103 35 Elena Elena NNP cord-005453-4057qib7 12103 36 Tagliaferri Tagliaferri NNP cord-005453-4057qib7 12103 37 1 1 CD cord-005453-4057qib7 12103 38 , , , cord-005453-4057qib7 12103 39 Nicola Nicola NNP cord-005453-4057qib7 12103 40 Fracchiolla Fracchiolla NNP cord-005453-4057qib7 12103 41 1 1 CD cord-005453-4057qib7 12103 42 , , , cord-005453-4057qib7 12103 43 Federica Federica NNP cord-005453-4057qib7 12103 44 Grifoni Grifoni NNP cord-005453-4057qib7 12103 45 1 1 CD cord-005453-4057qib7 12103 46 , , , cord-005453-4057qib7 12103 47 Giorgia Giorgia NNP cord-005453-4057qib7 12103 48 Levati Levati NNP cord-005453-4057qib7 12103 49 1 1 CD cord-005453-4057qib7 12103 50 , , , cord-005453-4057qib7 12103 51 Luca Luca NNP cord-005453-4057qib7 12103 52 Baldini Baldini NNP cord-005453-4057qib7 12103 53 1 1 CD cord-005453-4057qib7 12103 54 , , , cord-005453-4057qib7 12103 55 Francesco Francesco NNP cord-005453-4057qib7 12103 56 Onida Onida NNP cord-005453-4057qib7 12103 57 1 1 CD cord-005453-4057qib7 12103 58 the the DT cord-005453-4057qib7 12103 59 post post JJ cord-005453-4057qib7 12103 60 - - JJ cord-005453-4057qib7 12103 61 transplant transplant JJ cord-005453-4057qib7 12103 62 period period NN cord-005453-4057qib7 12103 63 with with IN cord-005453-4057qib7 12103 64 well well RB cord-005453-4057qib7 12103 65 - - HYPH cord-005453-4057qib7 12103 66 balanced balance VBN cord-005453-4057qib7 12103 67 profile profile NN cord-005453-4057qib7 12103 68 of of IN cord-005453-4057qib7 12103 69 good good JJ cord-005453-4057qib7 12103 70 efficacy efficacy NN cord-005453-4057qib7 12103 71 and and CC cord-005453-4057qib7 12103 72 moderate moderate JJ cord-005453-4057qib7 12103 73 toxicity toxicity NN cord-005453-4057qib7 12103 74 . . . cord-005453-4057qib7 12104 1 We -PRON- PRP cord-005453-4057qib7 12104 2 retrospectively retrospectively RB cord-005453-4057qib7 12104 3 evaluated evaluate VBD cord-005453-4057qib7 12104 4 the the DT cord-005453-4057qib7 12104 5 safety safety NN cord-005453-4057qib7 12104 6 and and CC cord-005453-4057qib7 12104 7 efficacy efficacy NN cord-005453-4057qib7 12104 8 of of IN cord-005453-4057qib7 12104 9 HMA HMA NNP cord-005453-4057qib7 12104 10 + + CC cord-005453-4057qib7 12104 11 /-DLI /-DLI . cord-005453-4057qib7 12105 1 in in IN cord-005453-4057qib7 12105 2 a a DT cord-005453-4057qib7 12105 3 reallife reallife JJ cord-005453-4057qib7 12105 4 cohort cohort NN cord-005453-4057qib7 12105 5 of of IN cord-005453-4057qib7 12105 6 AML AML NNP cord-005453-4057qib7 12105 7 patients patient NNS cord-005453-4057qib7 12105 8 relapsing relapse VBG cord-005453-4057qib7 12105 9 after after IN cord-005453-4057qib7 12105 10 allo allo NN cord-005453-4057qib7 12105 11 - - HYPH cord-005453-4057qib7 12105 12 SCT SCT NNP cord-005453-4057qib7 12105 13 . . . cord-005453-4057qib7 12106 1 Methods method NNS cord-005453-4057qib7 12106 2 : : : cord-005453-4057qib7 12107 1 Data datum NNS cord-005453-4057qib7 12107 2 from from IN cord-005453-4057qib7 12107 3 all all DT cord-005453-4057qib7 12107 4 patients patient NNS cord-005453-4057qib7 12107 5 with with IN cord-005453-4057qib7 12107 6 AML AML NNP cord-005453-4057qib7 12107 7 who who WP cord-005453-4057qib7 12107 8 underwent undergo VBD cord-005453-4057qib7 12107 9 allo allo NNP cord-005453-4057qib7 12107 10 - - HYPH cord-005453-4057qib7 12107 11 SCT SCT NNP cord-005453-4057qib7 12107 12 at at IN cord-005453-4057qib7 12107 13 our -PRON- PRP$ cord-005453-4057qib7 12107 14 Institution Institution NNP cord-005453-4057qib7 12107 15 in in IN cord-005453-4057qib7 12107 16 the the DT cord-005453-4057qib7 12107 17 last last JJ cord-005453-4057qib7 12107 18 6 6 CD cord-005453-4057qib7 12107 19 years year NNS cord-005453-4057qib7 12107 20 and and CC cord-005453-4057qib7 12107 21 subsequently subsequently RB cord-005453-4057qib7 12107 22 received receive VBD cord-005453-4057qib7 12107 23 HMA HMA NNP cord-005453-4057qib7 12107 24 as as IN cord-005453-4057qib7 12107 25 a a DT cord-005453-4057qib7 12107 26 salvage salvage NN cord-005453-4057qib7 12107 27 treatment treatment NN cord-005453-4057qib7 12107 28 for for IN cord-005453-4057qib7 12107 29 disease disease NN cord-005453-4057qib7 12107 30 recurrence recurrence NN cord-005453-4057qib7 12107 31 or or CC cord-005453-4057qib7 12107 32 preemptively preemptively RB cord-005453-4057qib7 12107 33 for for IN cord-005453-4057qib7 12107 34 loss loss NN cord-005453-4057qib7 12107 35 of of IN cord-005453-4057qib7 12107 36 complete complete JJ cord-005453-4057qib7 12107 37 donor donor NN cord-005453-4057qib7 12107 38 chimerism chimerism NN cord-005453-4057qib7 12107 39 were be VBD cord-005453-4057qib7 12107 40 collected collect VBN cord-005453-4057qib7 12107 41 . . . cord-005453-4057qib7 12108 1 Results result NNS cord-005453-4057qib7 12108 2 : : : cord-005453-4057qib7 12109 1 Eleven eleven CD cord-005453-4057qib7 12109 2 patients patient NNS cord-005453-4057qib7 12109 3 with with IN cord-005453-4057qib7 12109 4 a a DT cord-005453-4057qib7 12109 5 median median JJ cord-005453-4057qib7 12109 6 age age NN cord-005453-4057qib7 12109 7 of of IN cord-005453-4057qib7 12109 8 64 64 CD cord-005453-4057qib7 12109 9 years year NNS cord-005453-4057qib7 12109 10 ( ( -LRB- cord-005453-4057qib7 12109 11 range range NN cord-005453-4057qib7 12109 12 41 41 CD cord-005453-4057qib7 12109 13 - - SYM cord-005453-4057qib7 12109 14 66 66 CD cord-005453-4057qib7 12109 15 ) ) -RRB- cord-005453-4057qib7 12109 16 were be VBD cord-005453-4057qib7 12109 17 identified identify VBN cord-005453-4057qib7 12109 18 ; ; : cord-005453-4057qib7 12109 19 median median JJ cord-005453-4057qib7 12109 20 time time NN cord-005453-4057qib7 12109 21 between between IN cord-005453-4057qib7 12109 22 allo allo NN cord-005453-4057qib7 12109 23 - - HYPH cord-005453-4057qib7 12109 24 SCT sct NN cord-005453-4057qib7 12109 25 and and CC cord-005453-4057qib7 12109 26 time time NN cord-005453-4057qib7 12109 27 to to IN cord-005453-4057qib7 12109 28 HMA HMA NNP cord-005453-4057qib7 12109 29 therapy therapy NN cord-005453-4057qib7 12109 30 was be VBD cord-005453-4057qib7 12109 31 10 10 CD cord-005453-4057qib7 12109 32 months month NNS cord-005453-4057qib7 12110 1 ( ( -LRB- cord-005453-4057qib7 12110 2 range range NNP cord-005453-4057qib7 12110 3 4 4 CD cord-005453-4057qib7 12110 4 - - SYM cord-005453-4057qib7 12110 5 42 42 CD cord-005453-4057qib7 12110 6 ) ) -RRB- cord-005453-4057qib7 12110 7 . . . cord-005453-4057qib7 12111 1 According accord VBG cord-005453-4057qib7 12111 2 to to IN cord-005453-4057qib7 12111 3 ELN ELN NNP cord-005453-4057qib7 12111 4 genetic genetic JJ cord-005453-4057qib7 12111 5 risk risk NN cord-005453-4057qib7 12111 6 stratification stratification NN cord-005453-4057qib7 12111 7 , , , cord-005453-4057qib7 12111 8 2 2 CD cord-005453-4057qib7 12111 9 patients patient NNS cord-005453-4057qib7 12111 10 were be VBD cord-005453-4057qib7 12111 11 classified classify VBN cord-005453-4057qib7 12111 12 in in IN cord-005453-4057qib7 12111 13 the the DT cord-005453-4057qib7 12111 14 favorable favorable JJ cord-005453-4057qib7 12111 15 group group NN cord-005453-4057qib7 12111 16 , , , cord-005453-4057qib7 12111 17 3 3 CD cord-005453-4057qib7 12111 18 in in IN cord-005453-4057qib7 12111 19 the the DT cord-005453-4057qib7 12111 20 intermediate intermediate NN cord-005453-4057qib7 12111 21 - - : cord-005453-4057qib7 12111 22 I i NN cord-005453-4057qib7 12111 23 , , , cord-005453-4057qib7 12111 24 2 2 CD cord-005453-4057qib7 12111 25 in in IN cord-005453-4057qib7 12111 26 the the DT cord-005453-4057qib7 12111 27 intermediate intermediate JJ cord-005453-4057qib7 12111 28 - - HYPH cord-005453-4057qib7 12111 29 II II NNP cord-005453-4057qib7 12111 30 and and CC cord-005453-4057qib7 12111 31 4 4 CD cord-005453-4057qib7 12111 32 in in IN cord-005453-4057qib7 12111 33 the the DT cord-005453-4057qib7 12111 34 adverse adverse JJ cord-005453-4057qib7 12111 35 one one CD cord-005453-4057qib7 12111 36 . . . cord-005453-4057qib7 12112 1 Six six CD cord-005453-4057qib7 12112 2 patients patient NNS cord-005453-4057qib7 12112 3 were be VBD cord-005453-4057qib7 12112 4 treated treat VBN cord-005453-4057qib7 12112 5 with with IN cord-005453-4057qib7 12112 6 AZA AZA NNP cord-005453-4057qib7 12112 7 , , , cord-005453-4057qib7 12112 8 whereas whereas IN cord-005453-4057qib7 12112 9 the the DT cord-005453-4057qib7 12112 10 remaining remain VBG cord-005453-4057qib7 12112 11 5 5 CD cord-005453-4057qib7 12112 12 patients patient NNS cord-005453-4057qib7 12112 13 with with IN cord-005453-4057qib7 12112 14 DAC DAC NNP cord-005453-4057qib7 12112 15 . . . cord-005453-4057qib7 12113 1 The the DT cord-005453-4057qib7 12113 2 cycles cycle NNS cord-005453-4057qib7 12113 3 were be VBD cord-005453-4057qib7 12113 4 repeated repeat VBN cord-005453-4057qib7 12113 5 every every DT cord-005453-4057qib7 12113 6 28 28 CD cord-005453-4057qib7 12113 7 days day NNS cord-005453-4057qib7 12113 8 . . . cord-005453-4057qib7 12114 1 Ten ten CD cord-005453-4057qib7 12114 2 patients patient NNS cord-005453-4057qib7 12114 3 ( ( -LRB- cord-005453-4057qib7 12114 4 91 91 CD cord-005453-4057qib7 12114 5 % % NN cord-005453-4057qib7 12114 6 ) ) -RRB- cord-005453-4057qib7 12114 7 started start VBD cord-005453-4057qib7 12114 8 HMA HMA NNP cord-005453-4057qib7 12114 9 for for IN cord-005453-4057qib7 12114 10 morphological morphological JJ cord-005453-4057qib7 12114 11 AML AML NNP cord-005453-4057qib7 12114 12 relapse relapse NN cord-005453-4057qib7 12114 13 , , , cord-005453-4057qib7 12114 14 while while IN cord-005453-4057qib7 12114 15 one one CD cord-005453-4057qib7 12114 16 patient patient NN cord-005453-4057qib7 12114 17 received receive VBD cord-005453-4057qib7 12114 18 AZA AZA NNP cord-005453-4057qib7 12114 19 as as IN cord-005453-4057qib7 12114 20 a a DT cord-005453-4057qib7 12114 21 sequential sequential JJ cord-005453-4057qib7 12114 22 treatment treatment NN cord-005453-4057qib7 12114 23 after after IN cord-005453-4057qib7 12114 24 DLI DLI NNP cord-005453-4057qib7 12114 25 administered administer VBD cord-005453-4057qib7 12114 26 for for IN cord-005453-4057qib7 12114 27 loss loss NN cord-005453-4057qib7 12114 28 of of IN cord-005453-4057qib7 12114 29 complete complete JJ cord-005453-4057qib7 12114 30 donor donor NN cord-005453-4057qib7 12114 31 chimerism chimerism NN cord-005453-4057qib7 12114 32 . . . cord-005453-4057qib7 12115 1 Median median JJ cord-005453-4057qib7 12115 2 number number NN cord-005453-4057qib7 12115 3 of of IN cord-005453-4057qib7 12115 4 cycles cycle NNS cord-005453-4057qib7 12115 5 was be VBD cord-005453-4057qib7 12115 6 3 3 CD cord-005453-4057qib7 12116 1 ( ( -LRB- cord-005453-4057qib7 12116 2 range range NN cord-005453-4057qib7 12116 3 1 1 CD cord-005453-4057qib7 12116 4 -20 -20 CD cord-005453-4057qib7 12116 5 ) ) -RRB- cord-005453-4057qib7 12116 6 . . . cord-005453-4057qib7 12117 1 Treatment treatment NN cord-005453-4057qib7 12117 2 strategy strategy NN cord-005453-4057qib7 12117 3 included include VBD cord-005453-4057qib7 12117 4 combination combination NN cord-005453-4057qib7 12117 5 with with IN cord-005453-4057qib7 12117 6 DLI DLI NNP cord-005453-4057qib7 12117 7 in in IN cord-005453-4057qib7 12117 8 5 5 CD cord-005453-4057qib7 12117 9 patients patient NNS cord-005453-4057qib7 12117 10 ( ( -LRB- cord-005453-4057qib7 12117 11 2 2 CD cord-005453-4057qib7 12117 12 in in IN cord-005453-4057qib7 12117 13 the the DT cord-005453-4057qib7 12117 14 DAC DAC NNP cord-005453-4057qib7 12117 15 cohort cohort NN cord-005453-4057qib7 12117 16 , , , cord-005453-4057qib7 12117 17 3 3 CD cord-005453-4057qib7 12117 18 in in IN cord-005453-4057qib7 12117 19 the the DT cord-005453-4057qib7 12117 20 AZA AZA NNP cord-005453-4057qib7 12117 21 cohort cohort NN cord-005453-4057qib7 12117 22 ) ) -RRB- cord-005453-4057qib7 12117 23 , , , cord-005453-4057qib7 12117 24 while while IN cord-005453-4057qib7 12117 25 in in IN cord-005453-4057qib7 12117 26 one one CD cord-005453-4057qib7 12117 27 case case NN cord-005453-4057qib7 12117 28 of of IN cord-005453-4057qib7 12117 29 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 12117 30 + + CC cord-005453-4057qib7 12117 31 AML AML NNP cord-005453-4057qib7 12117 32 sorafenib sorafenib NNP cord-005453-4057qib7 12117 33 was be VBD cord-005453-4057qib7 12117 34 also also RB cord-005453-4057qib7 12117 35 associated associate VBN cord-005453-4057qib7 12117 36 to to IN cord-005453-4057qib7 12117 37 DAC DAC NNP cord-005453-4057qib7 12117 38 and and CC cord-005453-4057qib7 12117 39 DLI DLI NNP cord-005453-4057qib7 12117 40 . . . cord-005453-4057qib7 12118 1 No no DT cord-005453-4057qib7 12118 2 grade grade NN cord-005453-4057qib7 12118 3 3/4 3/4 CD cord-005453-4057qib7 12118 4 toxicities toxicity NNS cord-005453-4057qib7 12118 5 and and CC cord-005453-4057qib7 12118 6 no no DT cord-005453-4057qib7 12118 7 acute acute JJ cord-005453-4057qib7 12118 8 GvHD gvhd NN cord-005453-4057qib7 12118 9 occurred occur VBD cord-005453-4057qib7 12118 10 . . . cord-005453-4057qib7 12119 1 A a DT cord-005453-4057qib7 12119 2 clinically clinically RB cord-005453-4057qib7 12119 3 significant significant JJ cord-005453-4057qib7 12119 4 response response NN cord-005453-4057qib7 12119 5 was be VBD cord-005453-4057qib7 12119 6 observed observe VBN cord-005453-4057qib7 12119 7 in in IN cord-005453-4057qib7 12119 8 four four CD cord-005453-4057qib7 12119 9 patients patient NNS cord-005453-4057qib7 12119 10 ( ( -LRB- cord-005453-4057qib7 12119 11 36 36 CD cord-005453-4057qib7 12119 12 % % NN cord-005453-4057qib7 12119 13 ) ) -RRB- cord-005453-4057qib7 12119 14 , , , cord-005453-4057qib7 12119 15 all all DT cord-005453-4057qib7 12119 16 receiving receive VBG cord-005453-4057qib7 12119 17 at at IN cord-005453-4057qib7 12119 18 least least JJS cord-005453-4057qib7 12119 19 4 4 CD cord-005453-4057qib7 12119 20 cycles cycle NNS cord-005453-4057qib7 12119 21 of of IN cord-005453-4057qib7 12119 22 HMA HMA NNP cord-005453-4057qib7 12119 23 therapy therapy NN cord-005453-4057qib7 12119 24 ; ; : cord-005453-4057qib7 12119 25 in in IN cord-005453-4057qib7 12119 26 particular particular JJ cord-005453-4057qib7 12119 27 , , , cord-005453-4057qib7 12119 28 a a DT cord-005453-4057qib7 12119 29 complete complete JJ cord-005453-4057qib7 12119 30 remission remission NN cord-005453-4057qib7 12119 31 ( ( -LRB- cord-005453-4057qib7 12119 32 CR CR NNP cord-005453-4057qib7 12119 33 ) ) -RRB- cord-005453-4057qib7 12119 34 was be VBD cord-005453-4057qib7 12119 35 achieved achieve VBN cord-005453-4057qib7 12119 36 in in IN cord-005453-4057qib7 12119 37 3/10 3/10 CD cord-005453-4057qib7 12119 38 patients patient NNS cord-005453-4057qib7 12119 39 treated treat VBN cord-005453-4057qib7 12119 40 for for IN cord-005453-4057qib7 12119 41 morphological morphological JJ cord-005453-4057qib7 12119 42 relapse relapse NN cord-005453-4057qib7 12119 43 , , , cord-005453-4057qib7 12119 44 including include VBG cord-005453-4057qib7 12119 45 the the DT cord-005453-4057qib7 12119 46 one one NN cord-005453-4057qib7 12119 47 who who WP cord-005453-4057qib7 12119 48 received receive VBD cord-005453-4057qib7 12119 49 the the DT cord-005453-4057qib7 12119 50 DAC DAC NNP cord-005453-4057qib7 12119 51 / / SYM cord-005453-4057qib7 12119 52 DLI DLI NNP cord-005453-4057qib7 12119 53 / / SYM cord-005453-4057qib7 12119 54 sorafenib sorafenib NNP cord-005453-4057qib7 12119 55 combination combination NNP cord-005453-4057qib7 12119 56 and and CC cord-005453-4057qib7 12119 57 one one CD cord-005453-4057qib7 12119 58 ( ( -LRB- cord-005453-4057qib7 12119 59 favorable favorable JJ cord-005453-4057qib7 12119 60 ELN ELN NNP cord-005453-4057qib7 12119 61 risk risk NN cord-005453-4057qib7 12119 62 ) ) -RRB- cord-005453-4057qib7 12119 63 who who WP cord-005453-4057qib7 12119 64 received receive VBD cord-005453-4057qib7 12119 65 AZA AZA NNP cord-005453-4057qib7 12119 66 alone alone JJ cord-005453-4057qib7 12119 67 ( ( -LRB- cord-005453-4057qib7 12119 68 not not RB cord-005453-4057qib7 12119 69 eligible eligible JJ cord-005453-4057qib7 12119 70 for for IN cord-005453-4057qib7 12119 71 DLI DLI NNP cord-005453-4057qib7 12119 72 due due IN cord-005453-4057qib7 12119 73 to to IN cord-005453-4057qib7 12119 74 a a DT cord-005453-4057qib7 12119 75 concomitant concomitant JJ cord-005453-4057qib7 12119 76 lateonset lateonset NN cord-005453-4057qib7 12119 77 cutaneous cutaneous JJ cord-005453-4057qib7 12119 78 grade grade NN cord-005453-4057qib7 12119 79 2 2 CD cord-005453-4057qib7 12119 80 GvHD GvHD NNP cord-005453-4057qib7 12119 81 ) ) -RRB- cord-005453-4057qib7 12119 82 . . . cord-005453-4057qib7 12120 1 Of of IN cord-005453-4057qib7 12120 2 interest interest NN cord-005453-4057qib7 12120 3 , , , cord-005453-4057qib7 12120 4 the the DT cord-005453-4057qib7 12120 5 latter latter JJ cord-005453-4057qib7 12120 6 patient patient NN cord-005453-4057qib7 12120 7 also also RB cord-005453-4057qib7 12120 8 displayed display VBD cord-005453-4057qib7 12120 9 a a DT cord-005453-4057qib7 12120 10 resolution resolution NN cord-005453-4057qib7 12120 11 of of IN cord-005453-4057qib7 12120 12 the the DT cord-005453-4057qib7 12120 13 cutaneous cutaneous JJ cord-005453-4057qib7 12120 14 GvHD gvhd NN cord-005453-4057qib7 12120 15 . . . cord-005453-4057qib7 12121 1 Full full JJ cord-005453-4057qib7 12121 2 donor donor NN cord-005453-4057qib7 12121 3 chimerism chimerism NN cord-005453-4057qib7 12121 4 recovery recovery NN cord-005453-4057qib7 12121 5 with with IN cord-005453-4057qib7 12121 6 no no DT cord-005453-4057qib7 12121 7 GvHD gvhd NN cord-005453-4057qib7 12121 8 was be VBD cord-005453-4057qib7 12121 9 observed observe VBN cord-005453-4057qib7 12121 10 in in IN cord-005453-4057qib7 12121 11 the the DT cord-005453-4057qib7 12121 12 patient patient NN cord-005453-4057qib7 12121 13 who who WP cord-005453-4057qib7 12121 14 received receive VBD cord-005453-4057qib7 12121 15 AZA AZA NNP cord-005453-4057qib7 12121 16 for for IN cord-005453-4057qib7 12121 17 the the DT cord-005453-4057qib7 12121 18 progressive progressive JJ cord-005453-4057qib7 12121 19 donor donor NN cord-005453-4057qib7 12121 20 chimerism chimerism NN cord-005453-4057qib7 12121 21 loss loss NN cord-005453-4057qib7 12121 22 not not RB cord-005453-4057qib7 12121 23 responding respond VBG cord-005453-4057qib7 12121 24 to to IN cord-005453-4057qib7 12121 25 DLI DLI NNP cord-005453-4057qib7 12121 26 alone alone JJ cord-005453-4057qib7 12121 27 . . . cord-005453-4057qib7 12122 1 With with IN cord-005453-4057qib7 12122 2 a a DT cord-005453-4057qib7 12122 3 median median JJ cord-005453-4057qib7 12122 4 follow follow NN cord-005453-4057qib7 12122 5 - - HYPH cord-005453-4057qib7 12122 6 up up NN cord-005453-4057qib7 12122 7 of of IN cord-005453-4057qib7 12122 8 7 7 CD cord-005453-4057qib7 12122 9 months month NNS cord-005453-4057qib7 12122 10 ( ( -LRB- cord-005453-4057qib7 12122 11 range range VBP cord-005453-4057qib7 12122 12 4 4 CD cord-005453-4057qib7 12122 13 - - SYM cord-005453-4057qib7 12122 14 29 29 CD cord-005453-4057qib7 12122 15 ) ) -RRB- cord-005453-4057qib7 12122 16 , , , cord-005453-4057qib7 12122 17 the the DT cord-005453-4057qib7 12122 18 median median JJ cord-005453-4057qib7 12122 19 OS OS NNP cord-005453-4057qib7 12122 20 from from IN cord-005453-4057qib7 12122 21 HMA HMA NNP cord-005453-4057qib7 12122 22 treatment treatment NN cord-005453-4057qib7 12122 23 in in IN cord-005453-4057qib7 12122 24 responding respond VBG cord-005453-4057qib7 12122 25 patients patient NNS cord-005453-4057qib7 12122 26 was be VBD cord-005453-4057qib7 12122 27 16 16 CD cord-005453-4057qib7 12122 28 months month NNS cord-005453-4057qib7 12123 1 ( ( -LRB- cord-005453-4057qib7 12123 2 range range NNP cord-005453-4057qib7 12123 3 4 4 CD cord-005453-4057qib7 12123 4 - - SYM cord-005453-4057qib7 12123 5 29 29 CD cord-005453-4057qib7 12123 6 ) ) -RRB- cord-005453-4057qib7 12123 7 ; ; : cord-005453-4057qib7 12123 8 at at IN cord-005453-4057qib7 12123 9 the the DT cord-005453-4057qib7 12123 10 time time NN cord-005453-4057qib7 12123 11 of of IN cord-005453-4057qib7 12123 12 data datum NNS cord-005453-4057qib7 12123 13 collection collection NN cord-005453-4057qib7 12123 14 responses response NNS cord-005453-4057qib7 12123 15 were be VBD cord-005453-4057qib7 12123 16 maintained maintain VBN cord-005453-4057qib7 12123 17 in in IN cord-005453-4057qib7 12123 18 all all DT cord-005453-4057qib7 12123 19 four four CD cord-005453-4057qib7 12123 20 patients patient NNS cord-005453-4057qib7 12123 21 . . . cord-005453-4057qib7 12124 1 Seven seven CD cord-005453-4057qib7 12124 2 patients patient NNS cord-005453-4057qib7 12124 3 had have VBD cord-005453-4057qib7 12124 4 died die VBN cord-005453-4057qib7 12124 5 , , , cord-005453-4057qib7 12124 6 six six CD cord-005453-4057qib7 12124 7 from from IN cord-005453-4057qib7 12124 8 AML AML NNP cord-005453-4057qib7 12124 9 progression progression NN cord-005453-4057qib7 12124 10 and and CC cord-005453-4057qib7 12124 11 one one CD cord-005453-4057qib7 12124 12 for for IN cord-005453-4057qib7 12124 13 severe severe JJ cord-005453-4057qib7 12124 14 intestinal intestinal JJ cord-005453-4057qib7 12124 15 GvHD gvhd NN cord-005453-4057qib7 12124 16 occurring occur VBG cord-005453-4057qib7 12124 17 after after IN cord-005453-4057qib7 12124 18 failure failure NN cord-005453-4057qib7 12124 19 of of IN cord-005453-4057qib7 12124 20 DLI+AZA dli+aza NN cord-005453-4057qib7 12124 21 and and CC cord-005453-4057qib7 12124 22 a a DT cord-005453-4057qib7 12124 23 following follow VBG cord-005453-4057qib7 12124 24 salvage salvage NN cord-005453-4057qib7 12124 25 induction induction NN cord-005453-4057qib7 12124 26 chemotherapy chemotherapy NN cord-005453-4057qib7 12124 27 treatment treatment NN cord-005453-4057qib7 12124 28 . . . cord-005453-4057qib7 12125 1 Conclusions conclusion NNS cord-005453-4057qib7 12125 2 : : : cord-005453-4057qib7 12126 1 Although although IN cord-005453-4057qib7 12126 2 arising arise VBG cord-005453-4057qib7 12126 3 from from IN cord-005453-4057qib7 12126 4 a a DT cord-005453-4057qib7 12126 5 limited limited JJ cord-005453-4057qib7 12126 6 number number NN cord-005453-4057qib7 12126 7 of of IN cord-005453-4057qib7 12126 8 patients patient NNS cord-005453-4057qib7 12126 9 , , , cord-005453-4057qib7 12126 10 our -PRON- PRP$ cord-005453-4057qib7 12126 11 real real JJ cord-005453-4057qib7 12126 12 - - HYPH cord-005453-4057qib7 12126 13 life life NN cord-005453-4057qib7 12126 14 experience experience NN cord-005453-4057qib7 12126 15 of of IN cord-005453-4057qib7 12126 16 treatment treatment NN cord-005453-4057qib7 12126 17 with with IN cord-005453-4057qib7 12126 18 HMAs hma NNS cord-005453-4057qib7 12126 19 + + CC cord-005453-4057qib7 12126 20 /-DLI /-DLI . cord-005453-4057qib7 12127 1 in in IN cord-005453-4057qib7 12127 2 AML AML NNP cord-005453-4057qib7 12127 3 patients patient NNS cord-005453-4057qib7 12127 4 relapsing relapse VBG cord-005453-4057qib7 12127 5 after after IN cord-005453-4057qib7 12127 6 allo allo NN cord-005453-4057qib7 12127 7 - - HYPH cord-005453-4057qib7 12127 8 SCT SCT NNP cord-005453-4057qib7 12127 9 showed show VBD cord-005453-4057qib7 12127 10 a a DT cord-005453-4057qib7 12127 11 general general JJ cord-005453-4057qib7 12127 12 very very RB cord-005453-4057qib7 12127 13 good good JJ cord-005453-4057qib7 12127 14 safety safety NN cord-005453-4057qib7 12127 15 profile profile NN cord-005453-4057qib7 12127 16 and and CC cord-005453-4057qib7 12127 17 promising promising JJ cord-005453-4057qib7 12127 18 antileukemic antileukemic JJ cord-005453-4057qib7 12127 19 activity activity NN cord-005453-4057qib7 12127 20 , , , cord-005453-4057qib7 12127 21 altogether altogether RB cord-005453-4057qib7 12127 22 suggesting suggest VBG cord-005453-4057qib7 12127 23 a a DT cord-005453-4057qib7 12127 24 facilitation facilitation NN cord-005453-4057qib7 12127 25 of of IN cord-005453-4057qib7 12127 26 the the DT cord-005453-4057qib7 12127 27 graftversus graftversus NN cord-005453-4057qib7 12127 28 - - HYPH cord-005453-4057qib7 12127 29 leukemia leukemia NN cord-005453-4057qib7 12127 30 effect effect NN cord-005453-4057qib7 12127 31 ( ( -LRB- cord-005453-4057qib7 12127 32 GvL gvl NN cord-005453-4057qib7 12127 33 ) ) -RRB- cord-005453-4057qib7 12127 34 associated associate VBN cord-005453-4057qib7 12127 35 to to IN cord-005453-4057qib7 12127 36 a a DT cord-005453-4057qib7 12127 37 possible possible JJ cord-005453-4057qib7 12127 38 suppression suppression NN cord-005453-4057qib7 12127 39 of of IN cord-005453-4057qib7 12127 40 the the DT cord-005453-4057qib7 12127 41 GvH gvh JJ cord-005453-4057qib7 12127 42 reaction reaction NN cord-005453-4057qib7 12127 43 . . . cord-005453-4057qib7 12128 1 Disclosure disclosure NN cord-005453-4057qib7 12128 2 : : : cord-005453-4057qib7 12128 3 Nothing nothing NN cord-005453-4057qib7 12128 4 to to TO cord-005453-4057qib7 12128 5 declare declare VB cord-005453-4057qib7 12128 6 Conclusions conclusion NNS cord-005453-4057qib7 12128 7 : : : cord-005453-4057qib7 12128 8 In in IN cord-005453-4057qib7 12128 9 this this DT cord-005453-4057qib7 12128 10 study study NN cord-005453-4057qib7 12128 11 , , , cord-005453-4057qib7 12128 12 CD4-positive cd4-positive JJ cord-005453-4057qib7 12128 13 cell cell NN cord-005453-4057qib7 12128 14 count count NN cord-005453-4057qib7 12128 15 and and CC cord-005453-4057qib7 12128 16 IgG IgG NNP cord-005453-4057qib7 12128 17 value value NN cord-005453-4057qib7 12128 18 had have VBD cord-005453-4057qib7 12128 19 recovered recover VBN cord-005453-4057qib7 12128 20 about about RB cord-005453-4057qib7 12128 21 15 15 CD cord-005453-4057qib7 12128 22 months month NNS cord-005453-4057qib7 12128 23 after after IN cord-005453-4057qib7 12128 24 SCT SCT NNP cord-005453-4057qib7 12128 25 . . . cord-005453-4057qib7 12129 1 In in IN cord-005453-4057qib7 12129 2 our -PRON- PRP$ cord-005453-4057qib7 12129 3 institute institute NN cord-005453-4057qib7 12129 4 , , , cord-005453-4057qib7 12129 5 we -PRON- PRP cord-005453-4057qib7 12129 6 have have VBP cord-005453-4057qib7 12129 7 achieved achieve VBN cord-005453-4057qib7 12129 8 a a DT cord-005453-4057qib7 12129 9 low low JJ cord-005453-4057qib7 12129 10 incidence incidence NN cord-005453-4057qib7 12129 11 of of IN cord-005453-4057qib7 12129 12 infection infection NN cord-005453-4057qib7 12129 13 by by IN cord-005453-4057qib7 12129 14 education education NN cord-005453-4057qib7 12129 15 and and CC cord-005453-4057qib7 12129 16 medication medication NN cord-005453-4057qib7 12129 17 for for IN cord-005453-4057qib7 12129 18 patients patient NNS cord-005453-4057qib7 12129 19 until until IN cord-005453-4057qib7 12129 20 recovery recovery NN cord-005453-4057qib7 12129 21 of of IN cord-005453-4057qib7 12129 22 CD4-positive cd4-positive JJ cord-005453-4057qib7 12129 23 cell cell NN cord-005453-4057qib7 12129 24 count count NN cord-005453-4057qib7 12129 25 and and CC cord-005453-4057qib7 12130 1 IgG. IgG. NNP cord-005453-4057qib7 12131 1 However however RB cord-005453-4057qib7 12131 2 , , , cord-005453-4057qib7 12131 3 we -PRON- PRP cord-005453-4057qib7 12131 4 found find VBD cord-005453-4057qib7 12131 5 a a DT cord-005453-4057qib7 12131 6 higher high JJR cord-005453-4057qib7 12131 7 incidence incidence NN cord-005453-4057qib7 12131 8 of of IN cord-005453-4057qib7 12131 9 infection infection NN cord-005453-4057qib7 12131 10 after after IN cord-005453-4057qib7 12131 11 recovery recovery NN cord-005453-4057qib7 12131 12 of of IN cord-005453-4057qib7 12131 13 CD4-positive cd4-positive JJ cord-005453-4057qib7 12131 14 cell cell NN cord-005453-4057qib7 12131 15 count count NN cord-005453-4057qib7 12131 16 and and CC cord-005453-4057qib7 12132 1 IgG. IgG. NNP cord-005453-4057qib7 12133 1 At at IN cord-005453-4057qib7 12133 2 12 12 CD cord-005453-4057qib7 12133 3 - - SYM cord-005453-4057qib7 12133 4 15 15 CD cord-005453-4057qib7 12133 5 months month NNS cord-005453-4057qib7 12133 6 after after IN cord-005453-4057qib7 12133 7 SCT SCT NNP cord-005453-4057qib7 12133 8 , , , cord-005453-4057qib7 12133 9 administration administration NN cord-005453-4057qib7 12133 10 of of IN cord-005453-4057qib7 12133 11 prophylactic prophylactic JJ cord-005453-4057qib7 12133 12 medications medication NNS cord-005453-4057qib7 12133 13 such such JJ cord-005453-4057qib7 12133 14 as as IN cord-005453-4057qib7 12133 15 sulfamethoxazole sulfamethoxazole NNP cord-005453-4057qib7 12133 16 - - HYPH cord-005453-4057qib7 12133 17 trimethoprim trimethoprim NNP cord-005453-4057qib7 12133 18 were be VBD cord-005453-4057qib7 12133 19 terminated terminate VBN cord-005453-4057qib7 12133 20 and and CC cord-005453-4057qib7 12133 21 social social JJ cord-005453-4057qib7 12133 22 comeback comeback NN cord-005453-4057qib7 12133 23 such such JJ cord-005453-4057qib7 12133 24 as as IN cord-005453-4057qib7 12133 25 return return NN cord-005453-4057qib7 12133 26 to to IN cord-005453-4057qib7 12133 27 school school NN cord-005453-4057qib7 12133 28 or or CC cord-005453-4057qib7 12133 29 work work NN cord-005453-4057qib7 12133 30 were be VBD cord-005453-4057qib7 12133 31 achieved achieve VBN cord-005453-4057qib7 12133 32 in in IN cord-005453-4057qib7 12133 33 most most JJS cord-005453-4057qib7 12133 34 patients patient NNS cord-005453-4057qib7 12133 35 . . . cord-005453-4057qib7 12134 1 It -PRON- PRP cord-005453-4057qib7 12134 2 is be VBZ cord-005453-4057qib7 12134 3 possible possible JJ cord-005453-4057qib7 12134 4 that that IN cord-005453-4057qib7 12134 5 the the DT cord-005453-4057qib7 12134 6 high high JJ cord-005453-4057qib7 12134 7 incidence incidence NN cord-005453-4057qib7 12134 8 of of IN cord-005453-4057qib7 12134 9 community community NN cord-005453-4057qib7 12134 10 - - HYPH cord-005453-4057qib7 12134 11 acquired acquire VBN cord-005453-4057qib7 12134 12 infection infection NN cord-005453-4057qib7 12134 13 was be VBD cord-005453-4057qib7 12134 14 associated associate VBN cord-005453-4057qib7 12134 15 with with IN cord-005453-4057qib7 12134 16 their -PRON- PRP$ cord-005453-4057qib7 12134 17 comeback comeback NN cord-005453-4057qib7 12134 18 . . . cord-005453-4057qib7 12135 1 Thus thus RB cord-005453-4057qib7 12135 2 , , , cord-005453-4057qib7 12135 3 we -PRON- PRP cord-005453-4057qib7 12135 4 should should MD cord-005453-4057qib7 12135 5 consider consider VB cord-005453-4057qib7 12135 6 additional additional JJ cord-005453-4057qib7 12135 7 prevention prevention NN cord-005453-4057qib7 12135 8 of of IN cord-005453-4057qib7 12135 9 infection infection NN cord-005453-4057qib7 12135 10 for for IN cord-005453-4057qib7 12135 11 patients patient NNS cord-005453-4057qib7 12135 12 in in IN cord-005453-4057qib7 12135 13 this this DT cord-005453-4057qib7 12135 14 period period NN cord-005453-4057qib7 12135 15 and and CC cord-005453-4057qib7 12135 16 further further JJ cord-005453-4057qib7 12135 17 evaluation evaluation NN cord-005453-4057qib7 12135 18 of of IN cord-005453-4057qib7 12135 19 immunological immunological JJ cord-005453-4057qib7 12135 20 markers marker NNS cord-005453-4057qib7 12135 21 is be VBZ cord-005453-4057qib7 12135 22 needed need VBN cord-005453-4057qib7 12135 23 . . . cord-005453-4057qib7 12136 1 Disclosure disclosure NN cord-005453-4057qib7 12136 2 : : : cord-005453-4057qib7 12136 3 No no DT cord-005453-4057qib7 12136 4 potential potential JJ cord-005453-4057qib7 12136 5 conflicts conflict NNS cord-005453-4057qib7 12136 6 of of IN cord-005453-4057qib7 12136 7 interest interest NN cord-005453-4057qib7 12136 8 were be VBD cord-005453-4057qib7 12136 9 disclosed disclose VBN cord-005453-4057qib7 12136 10 . . . cord-005453-4057qib7 12137 1 Effect effect NN cord-005453-4057qib7 12137 2 of of IN cord-005453-4057qib7 12137 3 minimal minimal JJ cord-005453-4057qib7 12137 4 residual residual JJ cord-005453-4057qib7 12137 5 disease disease NN cord-005453-4057qib7 12137 6 before before IN cord-005453-4057qib7 12137 7 transplantation transplantation NN cord-005453-4057qib7 12137 8 on on IN cord-005453-4057qib7 12137 9 the the DT cord-005453-4057qib7 12137 10 outcome outcome NN cord-005453-4057qib7 12137 11 of of IN cord-005453-4057qib7 12137 12 haplo haplo NN cord-005453-4057qib7 12137 13 - - HYPH cord-005453-4057qib7 12137 14 identical identical JJ cord-005453-4057qib7 12137 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 12137 16 stem stem NN cord-005453-4057qib7 12137 17 cell cell NN cord-005453-4057qib7 12137 18 transplantation transplantation NN cord-005453-4057qib7 12137 19 for for IN cord-005453-4057qib7 12137 20 high high JJ cord-005453-4057qib7 12137 21 - - HYPH cord-005453-4057qib7 12137 22 risk risk NN cord-005453-4057qib7 12137 23 acute acute JJ cord-005453-4057qib7 12137 24 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 12137 25 leukemia leukemia NN cord-005453-4057qib7 12137 26 Yehui Yehui NNP cord-005453-4057qib7 12137 27 Tan Tan NNP cord-005453-4057qib7 12137 28 1 1 CD cord-005453-4057qib7 12137 29 , , , cord-005453-4057qib7 12137 30 Sujun Sujun NNP cord-005453-4057qib7 12137 31 Gao Gao NNP cord-005453-4057qib7 12137 32 1 1 CD cord-005453-4057qib7 12137 33 , , , cord-005453-4057qib7 12137 34 Xiaoliang Xiaoliang NNP cord-005453-4057qib7 12137 35 Liu Liu NNP cord-005453-4057qib7 12137 36 1 1 CD cord-005453-4057qib7 12137 37 , , , cord-005453-4057qib7 12137 38 Long Long NNP cord-005453-4057qib7 12137 39 Su Su NNP cord-005453-4057qib7 12137 40 1 1 CD cord-005453-4057qib7 12137 41 , , , cord-005453-4057qib7 12137 42 Wei Wei NNP cord-005453-4057qib7 12137 43 Han Han NNP cord-005453-4057qib7 12137 44 1 1 CD cord-005453-4057qib7 12137 45 , , , cord-005453-4057qib7 12137 46 Yu Yu NNP cord-005453-4057qib7 12137 47 Liu Liu NNP cord-005453-4057qib7 12137 48 1 1 CD cord-005453-4057qib7 12137 49 , , , cord-005453-4057qib7 12137 50 Yangzhi Yangzhi NNP cord-005453-4057qib7 12137 51 Zhao Zhao NNP cord-005453-4057qib7 12137 52 1 1 CD cord-005453-4057qib7 12137 53 Background background NN cord-005453-4057qib7 12137 54 : : : cord-005453-4057qib7 12138 1 To to TO cord-005453-4057qib7 12138 2 analyze analyze VB cord-005453-4057qib7 12138 3 the the DT cord-005453-4057qib7 12138 4 effect effect NN cord-005453-4057qib7 12138 5 of of IN cord-005453-4057qib7 12138 6 haploid haploid JJ cord-005453-4057qib7 12138 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 12138 8 stem stem NN cord-005453-4057qib7 12138 9 cell cell NN cord-005453-4057qib7 12138 10 transplantation transplantation NN cord-005453-4057qib7 12138 11 ( ( -LRB- cord-005453-4057qib7 12138 12 HID HID NNP cord-005453-4057qib7 12138 13 - - HYPH cord-005453-4057qib7 12138 14 HSCT HSCT NNP cord-005453-4057qib7 12138 15 ) ) -RRB- cord-005453-4057qib7 12138 16 on on IN cord-005453-4057qib7 12138 17 high high JJ cord-005453-4057qib7 12138 18 - - HYPH cord-005453-4057qib7 12138 19 risk risk NN cord-005453-4057qib7 12138 20 acute acute JJ cord-005453-4057qib7 12138 21 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 12138 22 leukemia leukemia NN cord-005453-4057qib7 12138 23 ( ( -LRB- cord-005453-4057qib7 12138 24 ALL all DT cord-005453-4057qib7 12138 25 ) ) -RRB- cord-005453-4057qib7 12138 26 , , , cord-005453-4057qib7 12138 27 and and CC cord-005453-4057qib7 12138 28 to to TO cord-005453-4057qib7 12138 29 explore explore VB cord-005453-4057qib7 12138 30 the the DT cord-005453-4057qib7 12138 31 effect effect NN cord-005453-4057qib7 12138 32 of of IN cord-005453-4057qib7 12138 33 minimal minimal JJ cord-005453-4057qib7 12138 34 residual residual JJ cord-005453-4057qib7 12138 35 disease disease NN cord-005453-4057qib7 12138 36 ( ( -LRB- cord-005453-4057qib7 12138 37 MRD MRD NNP cord-005453-4057qib7 12138 38 ) ) -RRB- cord-005453-4057qib7 12138 39 before before IN cord-005453-4057qib7 12138 40 transplant transplant NN cord-005453-4057qib7 12138 41 on on IN cord-005453-4057qib7 12138 42 the the DT cord-005453-4057qib7 12138 43 prognosis prognosis NN cord-005453-4057qib7 12138 44 . . . cord-005453-4057qib7 12139 1 Methods method NNS cord-005453-4057qib7 12139 2 : : : cord-005453-4057qib7 12139 3 A a DT cord-005453-4057qib7 12139 4 retrospective retrospective JJ cord-005453-4057qib7 12139 5 analysis analysis NN cord-005453-4057qib7 12139 6 was be VBD cord-005453-4057qib7 12139 7 made make VBN cord-005453-4057qib7 12139 8 on on IN cord-005453-4057qib7 12139 9 39 39 CD cord-005453-4057qib7 12139 10 high high JJ cord-005453-4057qib7 12139 11 risk risk NN cord-005453-4057qib7 12139 12 ALL all DT cord-005453-4057qib7 12139 13 patients patient NNS cord-005453-4057qib7 12139 14 accepted accept VBD cord-005453-4057qib7 12139 15 HID HID NNP cord-005453-4057qib7 12139 16 - - HYPH cord-005453-4057qib7 12139 17 HSCT HSCT NNP cord-005453-4057qib7 12139 18 in in IN cord-005453-4057qib7 12139 19 our -PRON- PRP$ cord-005453-4057qib7 12139 20 hospital hospital NN cord-005453-4057qib7 12139 21 from from IN cord-005453-4057qib7 12139 22 January January NNP cord-005453-4057qib7 12139 23 2013 2013 CD cord-005453-4057qib7 12139 24 to to IN cord-005453-4057qib7 12139 25 January January NNP cord-005453-4057qib7 12139 26 2018 2018 CD cord-005453-4057qib7 12139 27 . . . cord-005453-4057qib7 12140 1 The the DT cord-005453-4057qib7 12140 2 clinical clinical JJ cord-005453-4057qib7 12140 3 features feature NNS cord-005453-4057qib7 12140 4 , , , cord-005453-4057qib7 12140 5 stem stem NN cord-005453-4057qib7 12140 6 cell cell NN cord-005453-4057qib7 12140 7 implantation implantation NN cord-005453-4057qib7 12140 8 , , , cord-005453-4057qib7 12140 9 complications complication NNS cord-005453-4057qib7 12140 10 , , , cord-005453-4057qib7 12140 11 survival survival NN cord-005453-4057qib7 12140 12 and and CC cord-005453-4057qib7 12140 13 recurrence recurrence NN cord-005453-4057qib7 12140 14 were be VBD cord-005453-4057qib7 12140 15 compared compare VBN cord-005453-4057qib7 12140 16 between between IN cord-005453-4057qib7 12140 17 pre pre JJ cord-005453-4057qib7 12140 18 - - JJ cord-005453-4057qib7 12140 19 transplant transplant NN cord-005453-4057qib7 12140 20 MRD MRD NNP cord-005453-4057qib7 12140 21 + + SYM cord-005453-4057qib7 12140 22 and and CC cord-005453-4057qib7 12140 23 MRDpatients mrdpatient NNS cord-005453-4057qib7 12140 24 . . . cord-005453-4057qib7 12141 1 Results result NNS cord-005453-4057qib7 12141 2 : : : cord-005453-4057qib7 12142 1 All all PDT cord-005453-4057qib7 12142 2 the the DT cord-005453-4057qib7 12142 3 39 39 CD cord-005453-4057qib7 12142 4 patients patient NNS cord-005453-4057qib7 12142 5 got get VBD cord-005453-4057qib7 12142 6 successfully successfully RB cord-005453-4057qib7 12142 7 implanted implant VBN cord-005453-4057qib7 12142 8 . . . cord-005453-4057qib7 12143 1 The the DT cord-005453-4057qib7 12143 2 overall overall JJ cord-005453-4057qib7 12143 3 survival survival NN cord-005453-4057qib7 12143 4 ( ( -LRB- cord-005453-4057qib7 12143 5 OS OS NNP cord-005453-4057qib7 12143 6 ) ) -RRB- cord-005453-4057qib7 12143 7 was be VBD cord-005453-4057qib7 12143 8 54.67 54.67 CD cord-005453-4057qib7 12143 9 % % NN cord-005453-4057qib7 12143 10 , , , cord-005453-4057qib7 12143 11 the the DT cord-005453-4057qib7 12143 12 disease disease NN cord-005453-4057qib7 12143 13 free free JJ cord-005453-4057qib7 12143 14 survival survival NN cord-005453-4057qib7 12143 15 ( ( -LRB- cord-005453-4057qib7 12143 16 DFS DFS NNP cord-005453-4057qib7 12143 17 ) ) -RRB- cord-005453-4057qib7 12143 18 was be VBD cord-005453-4057qib7 12143 19 40.96 40.96 CD cord-005453-4057qib7 12143 20 % % NN cord-005453-4057qib7 12143 21 , , , cord-005453-4057qib7 12143 22 the the DT cord-005453-4057qib7 12143 23 incidence incidence NN cord-005453-4057qib7 12143 24 of of IN cord-005453-4057qib7 12143 25 acute acute JJ cord-005453-4057qib7 12143 26 graft graft NN cord-005453-4057qib7 12143 27 versus versus IN cord-005453-4057qib7 12143 28 host host NN cord-005453-4057qib7 12143 29 disease disease NN cord-005453-4057qib7 12143 30 ( ( -LRB- cord-005453-4057qib7 12143 31 aGVHD aGVHD NNP cord-005453-4057qib7 12143 32 ) ) -RRB- cord-005453-4057qib7 12143 33 was be VBD cord-005453-4057qib7 12143 34 53.8 53.8 CD cord-005453-4057qib7 12143 35 % % NN cord-005453-4057qib7 12143 36 , , , cord-005453-4057qib7 12143 37 including include VBG cord-005453-4057qib7 12143 38 23.1 23.1 CD cord-005453-4057qib7 12143 39 % % NN cord-005453-4057qib7 12143 40 II II NNP cord-005453-4057qib7 12143 41 ~ ~ NFP cord-005453-4057qib7 12143 42 IV IV NNP cord-005453-4057qib7 12143 43 degree degree NN cord-005453-4057qib7 12143 44 aGVHD agvhd NN cord-005453-4057qib7 12143 45 and and CC cord-005453-4057qib7 12143 46 2.6 2.6 CD cord-005453-4057qib7 12143 47 % % NN cord-005453-4057qib7 12143 48 III iii CD cord-005453-4057qib7 12144 1 ~IV ~IV NFP cord-005453-4057qib7 12144 2 degree degree NN cord-005453-4057qib7 12144 3 aGVHD aGVHD NNP cord-005453-4057qib7 12144 4 . . . cord-005453-4057qib7 12145 1 There there EX cord-005453-4057qib7 12145 2 was be VBD cord-005453-4057qib7 12145 3 no no DT cord-005453-4057qib7 12145 4 significant significant JJ cord-005453-4057qib7 12145 5 difference difference NN cord-005453-4057qib7 12145 6 in in IN cord-005453-4057qib7 12145 7 stem stem NN cord-005453-4057qib7 12145 8 cell cell NN cord-005453-4057qib7 12145 9 implantation implantation NN cord-005453-4057qib7 12145 10 , , , cord-005453-4057qib7 12145 11 GVHD GVHD NNP cord-005453-4057qib7 12145 12 , , , cord-005453-4057qib7 12145 13 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 12145 14 and and CC cord-005453-4057qib7 12145 15 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 12145 16 cystitis cystitis NN cord-005453-4057qib7 12145 17 between between IN cord-005453-4057qib7 12145 18 MRD MRD NNP cord-005453-4057qib7 12145 19 + + SYM cord-005453-4057qib7 12145 20 and and CC cord-005453-4057qib7 12145 21 MRDpatients mrdpatient NNS cord-005453-4057qib7 12145 22 . . . cord-005453-4057qib7 12146 1 DFS DFS NNP cord-005453-4057qib7 12146 2 and and CC cord-005453-4057qib7 12146 3 OS OS NNP cord-005453-4057qib7 12146 4 in in IN cord-005453-4057qib7 12146 5 MRD MRD NNP cord-005453-4057qib7 12146 6 + + CC cord-005453-4057qib7 12146 7 patients patient NNS cord-005453-4057qib7 12146 8 were be VBD cord-005453-4057qib7 12146 9 significantly significantly RB cord-005453-4057qib7 12146 10 lower low JJR cord-005453-4057qib7 12146 11 than than IN cord-005453-4057qib7 12146 12 those those DT cord-005453-4057qib7 12146 13 in in IN cord-005453-4057qib7 12146 14 MRD MRD NNP cord-005453-4057qib7 12146 15 -patients -patients NNP cord-005453-4057qib7 12146 16 , , , cord-005453-4057qib7 12146 17 and and CC cord-005453-4057qib7 12146 18 the the DT cord-005453-4057qib7 12146 19 cumulative cumulative JJ cord-005453-4057qib7 12146 20 RR rr NN cord-005453-4057qib7 12146 21 rate rate NN cord-005453-4057qib7 12146 22 increased increase VBD cord-005453-4057qib7 12146 23 significantly significantly RB cord-005453-4057qib7 12146 24 , , , cord-005453-4057qib7 12146 25 there there EX cord-005453-4057qib7 12146 26 was be VBD cord-005453-4057qib7 12146 27 no no DT cord-005453-4057qib7 12146 28 significant significant JJ cord-005453-4057qib7 12146 29 difference difference NN cord-005453-4057qib7 12146 30 in in IN cord-005453-4057qib7 12146 31 cumulative cumulative JJ cord-005453-4057qib7 12146 32 TRM TRM NNP cord-005453-4057qib7 12146 33 . . . cord-005453-4057qib7 12147 1 Conclusions conclusion NNS cord-005453-4057qib7 12147 2 : : : cord-005453-4057qib7 12147 3 HID HID NNP cord-005453-4057qib7 12147 4 - - HYPH cord-005453-4057qib7 12147 5 HSCT HSCT NNP cord-005453-4057qib7 12147 6 was be VBD cord-005453-4057qib7 12147 7 an an DT cord-005453-4057qib7 12147 8 effective effective JJ cord-005453-4057qib7 12147 9 method method NN cord-005453-4057qib7 12147 10 to to TO cord-005453-4057qib7 12147 11 treat treat VB cord-005453-4057qib7 12147 12 high high JJ cord-005453-4057qib7 12147 13 risk risk NN cord-005453-4057qib7 12147 14 ALL all DT cord-005453-4057qib7 12147 15 , , , cord-005453-4057qib7 12147 16 but but CC cord-005453-4057qib7 12147 17 MRD MRD NNP cord-005453-4057qib7 12147 18 + + SYM cord-005453-4057qib7 12147 19 patients patient NNS cord-005453-4057qib7 12147 20 had have VBD cord-005453-4057qib7 12147 21 high high JJ cord-005453-4057qib7 12147 22 recurrence recurrence NN cord-005453-4057qib7 12147 23 rate rate NN cord-005453-4057qib7 12147 24 and and CC cord-005453-4057qib7 12147 25 poor poor JJ cord-005453-4057qib7 12147 26 prognosis prognosis NN cord-005453-4057qib7 12147 27 . . . cord-005453-4057qib7 12148 1 Strategy Strategy NNP cord-005453-4057qib7 12148 2 Adjustment Adjustment NNP cord-005453-4057qib7 12148 3 should should MD cord-005453-4057qib7 12148 4 be be VB cord-005453-4057qib7 12148 5 considered consider VBN cord-005453-4057qib7 12148 6 to to TO cord-005453-4057qib7 12148 7 reduce reduce VB cord-005453-4057qib7 12148 8 tumor tumor NN cord-005453-4057qib7 12148 9 residual residual JJ cord-005453-4057qib7 12148 10 and and CC cord-005453-4057qib7 12148 11 the the DT cord-005453-4057qib7 12148 12 transplantation transplantation NN cord-005453-4057qib7 12148 13 strategy strategy NN cord-005453-4057qib7 12148 14 should should MD cord-005453-4057qib7 12148 15 be be VB cord-005453-4057qib7 12148 16 optimized optimize VBN cord-005453-4057qib7 12148 17 for for IN cord-005453-4057qib7 12148 18 these these DT cord-005453-4057qib7 12148 19 kind kind NN cord-005453-4057qib7 12148 20 of of IN cord-005453-4057qib7 12148 21 high high JJ cord-005453-4057qib7 12148 22 risk risk NN cord-005453-4057qib7 12148 23 patients patient NNS cord-005453-4057qib7 12148 24 , , , cord-005453-4057qib7 12148 25 so so IN cord-005453-4057qib7 12148 26 as as IN cord-005453-4057qib7 12148 27 to to TO cord-005453-4057qib7 12148 28 improve improve VB cord-005453-4057qib7 12148 29 survival survival NN cord-005453-4057qib7 12148 30 rate rate NN cord-005453-4057qib7 12148 31 . . . cord-005453-4057qib7 12149 1 Disclosure disclosure NN cord-005453-4057qib7 12149 2 : : : cord-005453-4057qib7 12149 3 Nothing nothing NN cord-005453-4057qib7 12149 4 to to TO cord-005453-4057qib7 12149 5 declare declare VB cord-005453-4057qib7 12149 6 Background background NN cord-005453-4057qib7 12149 7 : : : cord-005453-4057qib7 12150 1 Lymphocytes lymphocyte NNS cord-005453-4057qib7 12150 2 are be VBP cord-005453-4057qib7 12150 3 responsible responsible JJ cord-005453-4057qib7 12150 4 for for IN cord-005453-4057qib7 12150 5 the the DT cord-005453-4057qib7 12150 6 cellular cellular JJ cord-005453-4057qib7 12150 7 and and CC cord-005453-4057qib7 12150 8 humoral humoral JJ cord-005453-4057qib7 12150 9 immunity immunity NN cord-005453-4057qib7 12150 10 and and CC cord-005453-4057qib7 12150 11 , , , cord-005453-4057qib7 12150 12 consequently consequently RB cord-005453-4057qib7 12150 13 , , , cord-005453-4057qib7 12150 14 its -PRON- PRP$ cord-005453-4057qib7 12150 15 recovery recovery NN cord-005453-4057qib7 12150 16 after after IN cord-005453-4057qib7 12150 17 allo allo NN cord-005453-4057qib7 12150 18 - - HYPH cord-005453-4057qib7 12150 19 HSCT HSCT NNP cord-005453-4057qib7 12150 20 might may MD cord-005453-4057qib7 12150 21 be be VB cord-005453-4057qib7 12150 22 linked link VBN cord-005453-4057qib7 12150 23 with with IN cord-005453-4057qib7 12150 24 the the DT cord-005453-4057qib7 12150 25 survival survival NN cord-005453-4057qib7 12150 26 after after IN cord-005453-4057qib7 12150 27 the the DT cord-005453-4057qib7 12150 28 procedure procedure NN cord-005453-4057qib7 12150 29 . . . cord-005453-4057qib7 12151 1 The the DT cord-005453-4057qib7 12151 2 aim aim NN cord-005453-4057qib7 12151 3 of of IN cord-005453-4057qib7 12151 4 this this DT cord-005453-4057qib7 12151 5 study study NN cord-005453-4057qib7 12151 6 was be VBD cord-005453-4057qib7 12151 7 to to TO cord-005453-4057qib7 12151 8 analyze analyze VB cord-005453-4057qib7 12151 9 this this DT cord-005453-4057qib7 12151 10 hypothesis hypothesis NN cord-005453-4057qib7 12151 11 in in IN cord-005453-4057qib7 12151 12 our -PRON- PRP$ cord-005453-4057qib7 12151 13 series series NN cord-005453-4057qib7 12151 14 of of IN cord-005453-4057qib7 12151 15 patients patient NNS cord-005453-4057qib7 12151 16 . . . cord-005453-4057qib7 12152 1 Methods method NNS cord-005453-4057qib7 12152 2 : : : cord-005453-4057qib7 12152 3 All all PDT cord-005453-4057qib7 12152 4 the the DT cord-005453-4057qib7 12152 5 209 209 CD cord-005453-4057qib7 12152 6 allo allo NN cord-005453-4057qib7 12152 7 - - HYPH cord-005453-4057qib7 12152 8 HSCT HSCT NNP cord-005453-4057qib7 12152 9 performed perform VBD cord-005453-4057qib7 12152 10 in in IN cord-005453-4057qib7 12152 11 our -PRON- PRP$ cord-005453-4057qib7 12152 12 center center NN cord-005453-4057qib7 12152 13 from from IN cord-005453-4057qib7 12152 14 January January NNP cord-005453-4057qib7 12152 15 2015 2015 CD cord-005453-4057qib7 12152 16 through through IN cord-005453-4057qib7 12152 17 July July NNP cord-005453-4057qib7 12152 18 2018 2018 CD cord-005453-4057qib7 12152 19 were be VBD cord-005453-4057qib7 12152 20 included include VBN cord-005453-4057qib7 12152 21 in in IN cord-005453-4057qib7 12152 22 the the DT cord-005453-4057qib7 12152 23 analysis analysis NN cord-005453-4057qib7 12152 24 . . . cord-005453-4057qib7 12153 1 Median median JJ cord-005453-4057qib7 12153 2 age age NN cord-005453-4057qib7 12153 3 was be VBD cord-005453-4057qib7 12153 4 52 52 CD cord-005453-4057qib7 12153 5 years year NNS cord-005453-4057qib7 12154 1 ( ( -LRB- cord-005453-4057qib7 12154 2 range range NN cord-005453-4057qib7 12154 3 : : : cord-005453-4057qib7 12154 4 7 7 CD cord-005453-4057qib7 12154 5 - - SYM cord-005453-4057qib7 12154 6 69 69 CD cord-005453-4057qib7 12154 7 ) ) -RRB- cord-005453-4057qib7 12154 8 . . . cord-005453-4057qib7 12155 1 122 122 CD cord-005453-4057qib7 12155 2 pts pt NNS cord-005453-4057qib7 12155 3 were be VBD cord-005453-4057qib7 12155 4 male male JJ cord-005453-4057qib7 12155 5 ( ( -LRB- cord-005453-4057qib7 12155 6 58,4 58,4 CD cord-005453-4057qib7 12155 7 % % NN cord-005453-4057qib7 12155 8 ) ) -RRB- cord-005453-4057qib7 12155 9 and and CC cord-005453-4057qib7 12155 10 87 87 CD cord-005453-4057qib7 12155 11 were be VBD cord-005453-4057qib7 12155 12 female female JJ cord-005453-4057qib7 12155 13 ( ( -LRB- cord-005453-4057qib7 12155 14 41,6 41,6 CD cord-005453-4057qib7 12155 15 % % NN cord-005453-4057qib7 12155 16 ) ) -RRB- cord-005453-4057qib7 12155 17 . . . cord-005453-4057qib7 12156 1 Baseline baseline JJ cord-005453-4057qib7 12156 2 diseases disease NNS cord-005453-4057qib7 12156 3 were be VBD cord-005453-4057qib7 12156 4 : : : cord-005453-4057qib7 12156 5 69 69 CD cord-005453-4057qib7 12156 6 AML AML NNP cord-005453-4057qib7 12156 7 , , , cord-005453-4057qib7 12156 8 49 49 CD cord-005453-4057qib7 12156 9 LPD LPD NNP cord-005453-4057qib7 12156 10 , , , cord-005453-4057qib7 12156 11 31 31 CD cord-005453-4057qib7 12156 12 MDS MDS NNP cord-005453-4057qib7 12156 13 , , , cord-005453-4057qib7 12156 14 28 28 CD cord-005453-4057qib7 12156 15 ALL all DT cord-005453-4057qib7 12156 16 , , , cord-005453-4057qib7 12156 17 16 16 CD cord-005453-4057qib7 12156 18 MPD MPD NNP cord-005453-4057qib7 12156 19 , , , cord-005453-4057qib7 12156 20 10 10 CD cord-005453-4057qib7 12156 21 MM mm NN cord-005453-4057qib7 12156 22 , , , cord-005453-4057qib7 12156 23 and and CC cord-005453-4057qib7 12156 24 6 6 CD cord-005453-4057qib7 12156 25 BMF bmf NN cord-005453-4057qib7 12156 26 . . . cord-005453-4057qib7 12157 1 Donor donor NN cord-005453-4057qib7 12157 2 was be VBD cord-005453-4057qib7 12157 3 unrelated unrelated JJ cord-005453-4057qib7 12157 4 in in IN cord-005453-4057qib7 12157 5 113 113 CD cord-005453-4057qib7 12157 6 ( ( -LRB- cord-005453-4057qib7 12157 7 54,1 54,1 CD cord-005453-4057qib7 12157 8 % % NN cord-005453-4057qib7 12157 9 ) ) -RRB- cord-005453-4057qib7 12157 10 , , , cord-005453-4057qib7 12157 11 and and CC cord-005453-4057qib7 12157 12 was be VBD cord-005453-4057qib7 12157 13 family family NN cord-005453-4057qib7 12157 14 in in IN cord-005453-4057qib7 12157 15 96 96 CD cord-005453-4057qib7 12157 16 cases case NNS cord-005453-4057qib7 12157 17 ( ( -LRB- cord-005453-4057qib7 12157 18 45,9 45,9 CD cord-005453-4057qib7 12157 19 % % NN cord-005453-4057qib7 12157 20 ) ) -RRB- cord-005453-4057qib7 12157 21 ( ( -LRB- cord-005453-4057qib7 12157 22 including include VBG cord-005453-4057qib7 12157 23 31 31 CD cord-005453-4057qib7 12157 24 haplo haplo NN cord-005453-4057qib7 12157 25 - - HYPH cord-005453-4057qib7 12157 26 identical identical JJ cord-005453-4057qib7 12157 27 ) ) -RRB- cord-005453-4057qib7 12157 28 . . . cord-005453-4057qib7 12158 1 Stem stem JJ cord-005453-4057qib7 12158 2 cell cell NN cord-005453-4057qib7 12158 3 source source NN cord-005453-4057qib7 12158 4 was be VBD cord-005453-4057qib7 12158 5 PB PB NNP cord-005453-4057qib7 12158 6 in in IN cord-005453-4057qib7 12158 7 195 195 CD cord-005453-4057qib7 12158 8 ( ( -LRB- cord-005453-4057qib7 12158 9 93 93 CD cord-005453-4057qib7 12158 10 , , , cord-005453-4057qib7 12158 11 3 3 CD cord-005453-4057qib7 12158 12 % % NN cord-005453-4057qib7 12158 13 ) ) -RRB- cord-005453-4057qib7 12158 14 and and CC cord-005453-4057qib7 12158 15 BM BM NNP cord-005453-4057qib7 12158 16 in in IN cord-005453-4057qib7 12158 17 14 14 CD cord-005453-4057qib7 12158 18 pts pt NNS cord-005453-4057qib7 12158 19 ( ( -LRB- cord-005453-4057qib7 12158 20 6,7 6,7 CD cord-005453-4057qib7 12158 21 % % NN cord-005453-4057qib7 12158 22 ) ) -RRB- cord-005453-4057qib7 12158 23 . . . cord-005453-4057qib7 12159 1 Conditioning conditioning NN cord-005453-4057qib7 12159 2 regimen regimen NN cord-005453-4057qib7 12159 3 was be VBD cord-005453-4057qib7 12159 4 reduced reduce VBN cord-005453-4057qib7 12159 5 in in IN cord-005453-4057qib7 12159 6 111 111 CD cord-005453-4057qib7 12159 7 procedures procedure NNS cord-005453-4057qib7 12159 8 ( ( -LRB- cord-005453-4057qib7 12159 9 53,1 53,1 CD cord-005453-4057qib7 12159 10 % % NN cord-005453-4057qib7 12159 11 ) ) -RRB- cord-005453-4057qib7 12159 12 and and CC cord-005453-4057qib7 12159 13 intensive intensive JJ cord-005453-4057qib7 12159 14 in in IN cord-005453-4057qib7 12159 15 98 98 CD cord-005453-4057qib7 12159 16 ( ( -LRB- cord-005453-4057qib7 12159 17 46,9 46,9 CD cord-005453-4057qib7 12159 18 % % NN cord-005453-4057qib7 12159 19 ) ) -RRB- cord-005453-4057qib7 12159 20 ( ( -LRB- cord-005453-4057qib7 12159 21 including include VBG cord-005453-4057qib7 12159 22 just just RB cord-005453-4057qib7 12159 23 one one CD cord-005453-4057qib7 12159 24 non non JJ cord-005453-4057qib7 12159 25 - - JJ cord-005453-4057qib7 12159 26 myeloablative myeloablative JJ cord-005453-4057qib7 12159 27 ) ) -RRB- cord-005453-4057qib7 12159 28 . . . cord-005453-4057qib7 12160 1 Overall overall JJ cord-005453-4057qib7 12160 2 mortalities mortality NNS cord-005453-4057qib7 12160 3 at at IN cord-005453-4057qib7 12160 4 days day NNS cord-005453-4057qib7 12160 5 +100 +100 NNS cord-005453-4057qib7 12160 6 and and CC cord-005453-4057qib7 12160 7 +365 +365 NNP cord-005453-4057qib7 12161 1 ( ( -LRB- cord-005453-4057qib7 12161 2 the the DT cord-005453-4057qib7 12161 3 latter latter JJ cord-005453-4057qib7 12161 4 in in IN cord-005453-4057qib7 12161 5 patients patient NNS cord-005453-4057qib7 12161 6 with with IN cord-005453-4057qib7 12161 7 follow follow VB cord-005453-4057qib7 12161 8 - - HYPH cord-005453-4057qib7 12161 9 up up NN cord-005453-4057qib7 12161 10 superior superior JJ cord-005453-4057qib7 12161 11 to to IN cord-005453-4057qib7 12161 12 1 1 CD cord-005453-4057qib7 12161 13 year year NN cord-005453-4057qib7 12161 14 ) ) -RRB- cord-005453-4057qib7 12161 15 were be VBD cord-005453-4057qib7 12161 16 9,1 9,1 CD cord-005453-4057qib7 12161 17 % % NN cord-005453-4057qib7 12161 18 and and CC cord-005453-4057qib7 12161 19 24,9 24,9 CD cord-005453-4057qib7 12161 20 % % NN cord-005453-4057qib7 12161 21 , , , cord-005453-4057qib7 12161 22 respectively respectively RB cord-005453-4057qib7 12161 23 . . . cord-005453-4057qib7 12162 1 Median median JJ cord-005453-4057qib7 12162 2 follow follow NN cord-005453-4057qib7 12162 3 - - HYPH cord-005453-4057qib7 12162 4 up up NN cord-005453-4057qib7 12162 5 was be VBD cord-005453-4057qib7 12162 6 25 25 CD cord-005453-4057qib7 12162 7 months month NNS cord-005453-4057qib7 12163 1 ( ( -LRB- cord-005453-4057qib7 12163 2 range range NN cord-005453-4057qib7 12163 3 : : : cord-005453-4057qib7 12163 4 4 4 CD cord-005453-4057qib7 12163 5 - - SYM cord-005453-4057qib7 12163 6 47 47 CD cord-005453-4057qib7 12163 7 ) ) -RRB- cord-005453-4057qib7 12163 8 . . . cord-005453-4057qib7 12164 1 Evolution evolution NN cord-005453-4057qib7 12164 2 of of IN cord-005453-4057qib7 12164 3 absolute absolute JJ cord-005453-4057qib7 12164 4 lymphocyte lymphocyte NN cord-005453-4057qib7 12164 5 counts count NNS cord-005453-4057qib7 12164 6 ( ( -LRB- cord-005453-4057qib7 12164 7 ALC ALC NNP cord-005453-4057qib7 12164 8 ) ) -RRB- cord-005453-4057qib7 12164 9 and and CC cord-005453-4057qib7 12164 10 subpopulations subpopulation NNS cord-005453-4057qib7 12164 11 at at IN cord-005453-4057qib7 12164 12 pre pre JJ cord-005453-4057qib7 12164 13 - - JJ cord-005453-4057qib7 12164 14 HSCT HSCT NNP cord-005453-4057qib7 12164 15 and and CC cord-005453-4057qib7 12164 16 during during IN cord-005453-4057qib7 12164 17 the the DT cord-005453-4057qib7 12164 18 first first JJ cord-005453-4057qib7 12164 19 year year NN cord-005453-4057qib7 12164 20 after after IN cord-005453-4057qib7 12164 21 allo allo NN cord-005453-4057qib7 12164 22 - - HYPH cord-005453-4057qib7 12164 23 HSCT HSCT NNP cord-005453-4057qib7 12164 24 were be VBD cord-005453-4057qib7 12164 25 analyzed analyze VBN cord-005453-4057qib7 12164 26 . . . cord-005453-4057qib7 12165 1 Results result NNS cord-005453-4057qib7 12165 2 : : : cord-005453-4057qib7 12166 1 As as IN cord-005453-4057qib7 12166 2 shown show VBN cord-005453-4057qib7 12166 3 in in IN cord-005453-4057qib7 12166 4 table table NN cord-005453-4057qib7 12166 5 1 1 CD cord-005453-4057qib7 12166 6 , , , cord-005453-4057qib7 12166 7 ALC ALC NNP cord-005453-4057qib7 12166 8 and and CC cord-005453-4057qib7 12166 9 CD4 CD4 NNP cord-005453-4057qib7 12166 10 + + CC cord-005453-4057qib7 12166 11 lymphocytes lymphocyte NNS cord-005453-4057qib7 12166 12 decreased decrease VBD cord-005453-4057qib7 12166 13 after after IN cord-005453-4057qib7 12166 14 conditioning conditioning NN cord-005453-4057qib7 12166 15 therapy therapy NN cord-005453-4057qib7 12166 16 , , , cord-005453-4057qib7 12166 17 and and CC cord-005453-4057qib7 12166 18 recovered recover VBD cord-005453-4057qib7 12166 19 progressively progressively RB cord-005453-4057qib7 12166 20 during during IN cord-005453-4057qib7 12166 21 the the DT cord-005453-4057qib7 12166 22 post post JJ cord-005453-4057qib7 12166 23 - - JJ cord-005453-4057qib7 12166 24 HSCT hsct JJ cord-005453-4057qib7 12166 25 period period NN cord-005453-4057qib7 12166 26 . . . cord-005453-4057qib7 12167 1 At at IN cord-005453-4057qib7 12167 2 day day NN cord-005453-4057qib7 12167 3 +365 +365 NNP cord-005453-4057qib7 12167 4 , , , cord-005453-4057qib7 12167 5 majority majority NN cord-005453-4057qib7 12167 6 of of IN cord-005453-4057qib7 12167 7 patients patient NNS cord-005453-4057qib7 12167 8 had have VBD cord-005453-4057qib7 12167 9 > > $ cord-005453-4057qib7 12167 10 1000 1000 CD cord-005453-4057qib7 12167 11 ALC alc NN cord-005453-4057qib7 12167 12 / / SYM cord-005453-4057qib7 12167 13 mcL mcl NN cord-005453-4057qib7 12167 14 , , , cord-005453-4057qib7 12167 15 clearly clearly RB cord-005453-4057qib7 12167 16 improved improve VBN cord-005453-4057qib7 12167 17 compared compare VBN cord-005453-4057qib7 12167 18 to to IN cord-005453-4057qib7 12167 19 admission admission NN cord-005453-4057qib7 12167 20 values value NNS cord-005453-4057qib7 12167 21 . . . cord-005453-4057qib7 12168 1 CD4 CD4 NNP cord-005453-4057qib7 12168 2 + + CC cord-005453-4057qib7 12168 3 lymphocytes lymphocyte NNS cord-005453-4057qib7 12168 4 at at IN cord-005453-4057qib7 12168 5 day day NN cord-005453-4057qib7 12168 6 +100 +100 NNP cord-005453-4057qib7 12168 7 was be VBD cord-005453-4057qib7 12168 8 still still RB cord-005453-4057qib7 12168 9 very very RB cord-005453-4057qib7 12168 10 low low JJ cord-005453-4057qib7 12168 11 , , , cord-005453-4057qib7 12168 12 but but CC cord-005453-4057qib7 12168 13 at at IN cord-005453-4057qib7 12168 14 day day NN cord-005453-4057qib7 12168 15 +365 +365 XX cord-005453-4057qib7 12168 16 around around RB cord-005453-4057qib7 12169 1 half half NN cord-005453-4057qib7 12169 2 of of IN cord-005453-4057qib7 12169 3 the the DT cord-005453-4057qib7 12169 4 series series NN cord-005453-4057qib7 12169 5 had have VBD cord-005453-4057qib7 12169 6 200 200 CD cord-005453-4057qib7 12169 7 - - SYM cord-005453-4057qib7 12169 8 500 500 CD cord-005453-4057qib7 12169 9 / / SYM cord-005453-4057qib7 12169 10 mcL. mcl. NN cord-005453-4057qib7 12170 1 We -PRON- PRP cord-005453-4057qib7 12170 2 found find VBD cord-005453-4057qib7 12170 3 a a DT cord-005453-4057qib7 12170 4 strong strong JJ cord-005453-4057qib7 12170 5 link link NN cord-005453-4057qib7 12170 6 between between IN cord-005453-4057qib7 12170 7 ALC ALC NNP cord-005453-4057qib7 12170 8 , , , cord-005453-4057qib7 12170 9 CD4 CD4 NNP cord-005453-4057qib7 12170 10 + + CC cord-005453-4057qib7 12170 11 lymphocytes lymphocyte NNS cord-005453-4057qib7 12170 12 , , , cord-005453-4057qib7 12170 13 and and CC cord-005453-4057qib7 12171 1 CD19 CD19 NNP cord-005453-4057qib7 12171 2 + + CC cord-005453-4057qib7 12171 3 lymphocytes lymphocyte NNS cord-005453-4057qib7 12171 4 at at IN cord-005453-4057qib7 12171 5 days day NNS cord-005453-4057qib7 12171 6 +30 +30 CD cord-005453-4057qib7 12171 7 and and CC cord-005453-4057qib7 12171 8 day day NN cord-005453-4057qib7 12171 9 +100 +100 NNS cord-005453-4057qib7 12171 10 with with IN cord-005453-4057qib7 12171 11 overall overall JJ cord-005453-4057qib7 12171 12 survival survival NN cord-005453-4057qib7 12171 13 at at IN cord-005453-4057qib7 12171 14 day day NN cord-005453-4057qib7 12171 15 +365 +365 NNP cord-005453-4057qib7 12171 16 of of IN cord-005453-4057qib7 12171 17 the the DT cord-005453-4057qib7 12171 18 series series NN cord-005453-4057qib7 12171 19 ( ( -LRB- cord-005453-4057qib7 12171 20 table table NN cord-005453-4057qib7 12171 21 2 2 CD cord-005453-4057qib7 12171 22 ) ) -RRB- cord-005453-4057qib7 12171 23 . . . cord-005453-4057qib7 12172 1 Conclusions conclusion NNS cord-005453-4057qib7 12172 2 : : : cord-005453-4057qib7 12173 1 In in IN cord-005453-4057qib7 12173 2 our -PRON- PRP$ cord-005453-4057qib7 12173 3 series series NN cord-005453-4057qib7 12173 4 , , , cord-005453-4057qib7 12173 5 immunity immunity NN cord-005453-4057qib7 12173 6 recovery recovery NN cord-005453-4057qib7 12173 7 was be VBD cord-005453-4057qib7 12173 8 a a DT cord-005453-4057qib7 12173 9 late late JJ cord-005453-4057qib7 12173 10 event event NN cord-005453-4057qib7 12173 11 for for IN cord-005453-4057qib7 12173 12 majority majority NN cord-005453-4057qib7 12173 13 of of IN cord-005453-4057qib7 12173 14 patients patient NNS cord-005453-4057qib7 12173 15 undergoing undergo VBG cord-005453-4057qib7 12173 16 allo allo NN cord-005453-4057qib7 12173 17 - - HYPH cord-005453-4057qib7 12173 18 HSCT HSCT NNP cord-005453-4057qib7 12173 19 . . . cord-005453-4057qib7 12174 1 In in IN cord-005453-4057qib7 12174 2 addition addition NN cord-005453-4057qib7 12174 3 , , , cord-005453-4057qib7 12174 4 in in IN cord-005453-4057qib7 12174 5 our -PRON- PRP$ cord-005453-4057qib7 12174 6 experience experience NN cord-005453-4057qib7 12174 7 , , , cord-005453-4057qib7 12174 8 the the DT cord-005453-4057qib7 12174 9 precocity precocity NN cord-005453-4057qib7 12174 10 and and CC cord-005453-4057qib7 12174 11 quality quality NN cord-005453-4057qib7 12174 12 of of IN cord-005453-4057qib7 12174 13 the the DT cord-005453-4057qib7 12174 14 ALC ALC NNP cord-005453-4057qib7 12174 15 , , , cord-005453-4057qib7 12174 16 CD4 CD4 NNP cord-005453-4057qib7 12174 17 + + CC cord-005453-4057qib7 12174 18 , , , cord-005453-4057qib7 12174 19 and and CC cord-005453-4057qib7 12174 20 CD19 CD19 NNP cord-005453-4057qib7 12174 21 + + CC cord-005453-4057qib7 12174 22 cells cell NNS cord-005453-4057qib7 12174 23 recovery recovery NN cord-005453-4057qib7 12174 24 was be VBD cord-005453-4057qib7 12174 25 clearly clearly RB cord-005453-4057qib7 12174 26 linked link VBN cord-005453-4057qib7 12174 27 with with IN cord-005453-4057qib7 12174 28 long long JJ cord-005453-4057qib7 12174 29 - - HYPH cord-005453-4057qib7 12174 30 term term NN cord-005453-4057qib7 12174 31 survival survival NN cord-005453-4057qib7 12174 32 . . . cord-005453-4057qib7 12175 1 Background background NN cord-005453-4057qib7 12175 2 : : : cord-005453-4057qib7 12176 1 The the DT cord-005453-4057qib7 12176 2 reconstitution reconstitution NN cord-005453-4057qib7 12176 3 of of IN cord-005453-4057qib7 12176 4 T T NNP cord-005453-4057qib7 12176 5 and and CC cord-005453-4057qib7 12176 6 Natural Natural NNP cord-005453-4057qib7 12176 7 Killer Killer NNP cord-005453-4057qib7 12176 8 ( ( -LRB- cord-005453-4057qib7 12176 9 NK NK NNP cord-005453-4057qib7 12176 10 ) ) -RRB- cord-005453-4057qib7 12176 11 cells cell NNS cord-005453-4057qib7 12176 12 after after IN cord-005453-4057qib7 12176 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 12176 14 stem stem NN cord-005453-4057qib7 12176 15 cell cell NN cord-005453-4057qib7 12176 16 transplantation transplantation NN cord-005453-4057qib7 12176 17 ( ( -LRB- cord-005453-4057qib7 12176 18 HSCT HSCT NNP cord-005453-4057qib7 12176 19 ) ) -RRB- cord-005453-4057qib7 12176 20 strongly strongly RB cord-005453-4057qib7 12176 21 influences influence VBZ cord-005453-4057qib7 12176 22 the the DT cord-005453-4057qib7 12176 23 outcome outcome NN cord-005453-4057qib7 12176 24 of of IN cord-005453-4057qib7 12176 25 HSCT HSCT NNP cord-005453-4057qib7 12176 26 including include VBG cord-005453-4057qib7 12176 27 viral viral JJ cord-005453-4057qib7 12176 28 infection infection NN cord-005453-4057qib7 12176 29 and and CC cord-005453-4057qib7 12176 30 graft graft NN cord-005453-4057qib7 12176 31 versus versus IN cord-005453-4057qib7 12176 32 - - HYPH cord-005453-4057qib7 12176 33 host host NN cord-005453-4057qib7 12176 34 disease disease NN cord-005453-4057qib7 12176 35 ( ( -LRB- cord-005453-4057qib7 12176 36 GVHD GVHD NNP cord-005453-4057qib7 12176 37 ) ) -RRB- cord-005453-4057qib7 12176 38 . . . cord-005453-4057qib7 12177 1 The the DT cord-005453-4057qib7 12177 2 purpose purpose NN cord-005453-4057qib7 12177 3 of of IN cord-005453-4057qib7 12177 4 this this DT cord-005453-4057qib7 12177 5 study study NN cord-005453-4057qib7 12177 6 was be VBD cord-005453-4057qib7 12177 7 to to TO cord-005453-4057qib7 12177 8 investigate investigate VB cord-005453-4057qib7 12177 9 the the DT cord-005453-4057qib7 12177 10 clinical clinical JJ cord-005453-4057qib7 12177 11 efficacy efficacy NN cord-005453-4057qib7 12177 12 of of IN cord-005453-4057qib7 12177 13 immune immune JJ cord-005453-4057qib7 12177 14 reconstitution reconstitution NN cord-005453-4057qib7 12177 15 including include VBG cord-005453-4057qib7 12177 16 T T NNP cord-005453-4057qib7 12177 17 and and CC cord-005453-4057qib7 12177 18 NK NK NNP cord-005453-4057qib7 12177 19 cells cell NNS cord-005453-4057qib7 12177 20 after after IN cord-005453-4057qib7 12177 21 HSCT HSCT NNP cord-005453-4057qib7 12177 22 in in IN cord-005453-4057qib7 12177 23 children child NNS cord-005453-4057qib7 12177 24 . . . cord-005453-4057qib7 12178 1 Methods method NNS cord-005453-4057qib7 12179 1 : : : cord-005453-4057qib7 12179 2 We -PRON- PRP cord-005453-4057qib7 12179 3 reviewed review VBD cord-005453-4057qib7 12179 4 the the DT cord-005453-4057qib7 12179 5 records record NNS cord-005453-4057qib7 12179 6 of of IN cord-005453-4057qib7 12179 7 30 30 CD cord-005453-4057qib7 12179 8 patients patient NNS cord-005453-4057qib7 12179 9 who who WP cord-005453-4057qib7 12179 10 undergoing undergo VBG cord-005453-4057qib7 12179 11 allogeneic allogeneic IN cord-005453-4057qib7 12179 12 HSCT HSCT NNP cord-005453-4057qib7 12179 13 in in IN cord-005453-4057qib7 12179 14 Department Department NNP cord-005453-4057qib7 12179 15 of of IN cord-005453-4057qib7 12179 16 Pediatrics Pediatrics NNP cord-005453-4057qib7 12179 17 , , , cord-005453-4057qib7 12179 18 Pusan Pusan NNP cord-005453-4057qib7 12179 19 National National NNP cord-005453-4057qib7 12179 20 University University NNP cord-005453-4057qib7 12179 21 Children Children NNP cord-005453-4057qib7 12179 22 's 's POS cord-005453-4057qib7 12179 23 Hospital Hospital NNP cord-005453-4057qib7 12179 24 , , , cord-005453-4057qib7 12179 25 from from IN cord-005453-4057qib7 12179 26 January January NNP cord-005453-4057qib7 12179 27 2013 2013 CD cord-005453-4057qib7 12179 28 to to IN cord-005453-4057qib7 12179 29 July July NNP cord-005453-4057qib7 12179 30 2017 2017 CD cord-005453-4057qib7 12179 31 . . . cord-005453-4057qib7 12180 1 The the DT cord-005453-4057qib7 12180 2 counts count NNS cord-005453-4057qib7 12180 3 of of IN cord-005453-4057qib7 12180 4 T t NN cord-005453-4057qib7 12180 5 lymphocyte lymphocyte NN cord-005453-4057qib7 12180 6 subsets subset NNS cord-005453-4057qib7 12180 7 and and CC cord-005453-4057qib7 12180 8 NK NK NNP cord-005453-4057qib7 12180 9 cells cell NNS cord-005453-4057qib7 12180 10 was be VBD cord-005453-4057qib7 12180 11 monitored monitor VBN cord-005453-4057qib7 12180 12 in in IN cord-005453-4057qib7 12180 13 peripheral peripheral JJ cord-005453-4057qib7 12180 14 blood blood NN cord-005453-4057qib7 12180 15 by by IN cord-005453-4057qib7 12180 16 flow flow NN cord-005453-4057qib7 12180 17 cytometric cytometric NN cord-005453-4057qib7 12180 18 technique technique NN cord-005453-4057qib7 12180 19 during during IN cord-005453-4057qib7 12180 20 1 1 CD cord-005453-4057qib7 12180 21 , , , cord-005453-4057qib7 12180 22 3 3 CD cord-005453-4057qib7 12180 23 , , , cord-005453-4057qib7 12180 24 6 6 CD cord-005453-4057qib7 12180 25 , , , cord-005453-4057qib7 12180 26 and and CC cord-005453-4057qib7 12180 27 12 12 CD cord-005453-4057qib7 12180 28 months month NNS cord-005453-4057qib7 12180 29 post post NN cord-005453-4057qib7 12180 30 - - JJ cord-005453-4057qib7 12180 31 HSCT HSCT NNP cord-005453-4057qib7 12180 32 . . . cord-005453-4057qib7 12181 1 Blood blood NN cord-005453-4057qib7 12181 2 samples sample NNS cord-005453-4057qib7 12181 3 for for IN cord-005453-4057qib7 12181 4 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 12181 5 ( ( -LRB- cord-005453-4057qib7 12181 6 CMV CMV NNP cord-005453-4057qib7 12181 7 ) ) -RRB- cord-005453-4057qib7 12181 8 and and CC cord-005453-4057qib7 12181 9 Epstein Epstein NNP cord-005453-4057qib7 12181 10 - - HYPH cord-005453-4057qib7 12181 11 Barr Barr NNP cord-005453-4057qib7 12181 12 virus virus NN cord-005453-4057qib7 12181 13 ( ( -LRB- cord-005453-4057qib7 12181 14 EBV EBV NNP cord-005453-4057qib7 12181 15 ) ) -RRB- cord-005453-4057qib7 12181 16 monitoring monitoring NN cord-005453-4057qib7 12181 17 were be VBD cord-005453-4057qib7 12181 18 tested test VBN cord-005453-4057qib7 12181 19 by by IN cord-005453-4057qib7 12181 20 real real JJ cord-005453-4057qib7 12181 21 - - HYPH cord-005453-4057qib7 12181 22 time time NN cord-005453-4057qib7 12181 23 PCR pcr NN cord-005453-4057qib7 12181 24 assay assay NN cord-005453-4057qib7 12181 25 . . . cord-005453-4057qib7 12182 1 Results result NNS cord-005453-4057qib7 12182 2 : : : cord-005453-4057qib7 12183 1 For for IN cord-005453-4057qib7 12183 2 total total NN cord-005453-4057qib7 12183 3 of of IN cord-005453-4057qib7 12183 4 30 30 CD cord-005453-4057qib7 12183 5 patients patient NNS cord-005453-4057qib7 12183 6 , , , cord-005453-4057qib7 12183 7 the the DT cord-005453-4057qib7 12183 8 mean mean JJ cord-005453-4057qib7 12183 9 age age NN cord-005453-4057qib7 12183 10 was be VBD cord-005453-4057qib7 12183 11 9.1 9.1 CD cord-005453-4057qib7 12183 12 years year NNS cord-005453-4057qib7 12183 13 ( ( -LRB- cord-005453-4057qib7 12183 14 range range NN cord-005453-4057qib7 12183 15 , , , cord-005453-4057qib7 12183 16 9 9 CD cord-005453-4057qib7 12183 17 months-19 months-19 CD cord-005453-4057qib7 12183 18 years year NNS cord-005453-4057qib7 12183 19 ) ) -RRB- cord-005453-4057qib7 12183 20 , , , cord-005453-4057qib7 12183 21 16 16 CD cord-005453-4057qib7 12183 22 of of IN cord-005453-4057qib7 12183 23 the the DT cord-005453-4057qib7 12183 24 patients patient NNS cord-005453-4057qib7 12183 25 were be VBD cord-005453-4057qib7 12184 1 boys boy NNS cord-005453-4057qib7 12184 2 and and CC cord-005453-4057qib7 12184 3 14 14 CD cord-005453-4057qib7 12184 4 was be VBD cord-005453-4057qib7 12184 5 girl girl NN cord-005453-4057qib7 12184 6 . . . cord-005453-4057qib7 12185 1 Out out IN cord-005453-4057qib7 12185 2 of of IN cord-005453-4057qib7 12185 3 a a DT cord-005453-4057qib7 12185 4 total total JJ cord-005453-4057qib7 12185 5 30 30 CD cord-005453-4057qib7 12185 6 patients patient NNS cord-005453-4057qib7 12185 7 without without IN cord-005453-4057qib7 12185 8 pre pre JJ cord-005453-4057qib7 12185 9 - - JJ cord-005453-4057qib7 12185 10 HSCT HSCT NNP cord-005453-4057qib7 12185 11 CMV CMV NNP cord-005453-4057qib7 12185 12 viremia viremia NN cord-005453-4057qib7 12185 13 or or CC cord-005453-4057qib7 12185 14 CMV CMV NNP cord-005453-4057qib7 12185 15 infection infection NN cord-005453-4057qib7 12185 16 , , , cord-005453-4057qib7 12185 17 10 10 CD cord-005453-4057qib7 12185 18 ( ( -LRB- cord-005453-4057qib7 12185 19 33.3 33.3 CD cord-005453-4057qib7 12185 20 % % NN cord-005453-4057qib7 12185 21 ) ) -RRB- cord-005453-4057qib7 12185 22 recipients recipient NNS cord-005453-4057qib7 12185 23 experienced experience VBD cord-005453-4057qib7 12185 24 CMV CMV NNP cord-005453-4057qib7 12185 25 infection infection NN cord-005453-4057qib7 12185 26 . . . cord-005453-4057qib7 12186 1 The the DT cord-005453-4057qib7 12186 2 number number NN cord-005453-4057qib7 12186 3 of of IN cord-005453-4057qib7 12186 4 CD8 CD8 NNP cord-005453-4057qib7 12186 5 + + CC cord-005453-4057qib7 12186 6 T T NNP cord-005453-4057qib7 12186 7 cells cell NNS cord-005453-4057qib7 12186 8 in in IN cord-005453-4057qib7 12186 9 3 3 CD cord-005453-4057qib7 12186 10 and and CC cord-005453-4057qib7 12186 11 6 6 CD cord-005453-4057qib7 12186 12 months month NNS cord-005453-4057qib7 12186 13 post post NN cord-005453-4057qib7 12186 14 - - JJ cord-005453-4057qib7 12186 15 HSCT HSCT NNP cord-005453-4057qib7 12186 16 was be VBD cord-005453-4057qib7 12186 17 significantly significantly RB cord-005453-4057qib7 12186 18 higher high JJR cord-005453-4057qib7 12186 19 in in IN cord-005453-4057qib7 12186 20 patients patient NNS cord-005453-4057qib7 12186 21 with with IN cord-005453-4057qib7 12186 22 CMV CMV NNP cord-005453-4057qib7 12186 23 reactivation reactivation NN cord-005453-4057qib7 12186 24 compared compare VBN cord-005453-4057qib7 12186 25 to to IN cord-005453-4057qib7 12186 26 patients patient NNS cord-005453-4057qib7 12186 27 without without IN cord-005453-4057qib7 12186 28 ( ( -LRB- cord-005453-4057qib7 12186 29 median median JJ cord-005453-4057qib7 12186 30 1066.11/ 1066.11/ CD cord-005453-4057qib7 12187 1 μL μL . cord-005453-4057qib7 12188 1 vs. vs. FW cord-005453-4057qib7 12189 1 979.0 979.0 CD cord-005453-4057qib7 12189 2 / / SYM cord-005453-4057qib7 12189 3 μL μL NNP cord-005453-4057qib7 12189 4 , , , cord-005453-4057qib7 12189 5 P=0.004 p=0.004 NN cord-005453-4057qib7 12189 6 , , , cord-005453-4057qib7 12189 7 and and CC cord-005453-4057qib7 12189 8 1047.45/ 1047.45/ CD cord-005453-4057qib7 12190 1 μL μL . cord-005453-4057qib7 12191 1 vs. vs. FW cord-005453-4057qib7 12191 2 551.44 551.44 CD cord-005453-4057qib7 12192 1 /μL /μL NFP cord-005453-4057qib7 12192 2 , , , cord-005453-4057qib7 12192 3 P=0.002 P=0.002 NNP cord-005453-4057qib7 12192 4 ) ) -RRB- cord-005453-4057qib7 12192 5 . . . cord-005453-4057qib7 12193 1 In in IN cord-005453-4057qib7 12193 2 6 6 CD cord-005453-4057qib7 12193 3 ( ( -LRB- cord-005453-4057qib7 12193 4 20 20 CD cord-005453-4057qib7 12193 5 % % NN cord-005453-4057qib7 12193 6 ) ) -RRB- cord-005453-4057qib7 12193 7 recipients recipient NNS cord-005453-4057qib7 12193 8 presented present VBD cord-005453-4057qib7 12193 9 acute acute JJ cord-005453-4057qib7 12193 10 GVHD GVHD NNP cord-005453-4057qib7 12193 11 , , , cord-005453-4057qib7 12193 12 the the DT cord-005453-4057qib7 12193 13 number number NN cord-005453-4057qib7 12193 14 of of IN cord-005453-4057qib7 12193 15 CD4 CD4 NNP cord-005453-4057qib7 12193 16 + + CC cord-005453-4057qib7 12193 17 T T NNP cord-005453-4057qib7 12193 18 cells cell NNS cord-005453-4057qib7 12193 19 in in IN cord-005453-4057qib7 12193 20 1 1 CD cord-005453-4057qib7 12193 21 and and CC cord-005453-4057qib7 12193 22 3 3 CD cord-005453-4057qib7 12193 23 months month NNS cord-005453-4057qib7 12193 24 post post JJ cord-005453-4057qib7 12193 25 - - JJ cord-005453-4057qib7 12193 26 HSCT HSCT NNP cord-005453-4057qib7 12193 27 was be VBD cord-005453-4057qib7 12193 28 significantly significantly RB cord-005453-4057qib7 12193 29 lower low JJR cord-005453-4057qib7 12193 30 in in IN cord-005453-4057qib7 12193 31 patients patient NNS cord-005453-4057qib7 12193 32 with with IN cord-005453-4057qib7 12193 33 acute acute JJ cord-005453-4057qib7 12193 34 GVHD GVHD NNP cord-005453-4057qib7 12193 35 compared compare VBN cord-005453-4057qib7 12193 36 to to IN cord-005453-4057qib7 12193 37 patients patient NNS cord-005453-4057qib7 12193 38 without without IN cord-005453-4057qib7 12193 39 ( ( -LRB- cord-005453-4057qib7 12193 40 median median NN cord-005453-4057qib7 12193 41 239.13/ 239.13/ CD cord-005453-4057qib7 12194 1 μL μL . cord-005453-4057qib7 12195 1 vs. vs. FW cord-005453-4057qib7 12196 1 365.0 365.0 CD cord-005453-4057qib7 12196 2 / / SYM cord-005453-4057qib7 12196 3 μL μL NNP cord-005453-4057qib7 12196 4 , , , cord-005453-4057qib7 12196 5 P=0.045 p=0.045 NN cord-005453-4057qib7 12196 6 , , , cord-005453-4057qib7 12196 7 and and CC cord-005453-4057qib7 12197 1 165.2 165.2 CD cord-005453-4057qib7 12197 2 / / SYM cord-005453-4057qib7 12197 3 μL μl NN cord-005453-4057qib7 12197 4 vs. vs. IN cord-005453-4057qib7 12197 5 344.27 344.27 CD cord-005453-4057qib7 12197 6 / / SYM cord-005453-4057qib7 12197 7 μL μL NNP cord-005453-4057qib7 12197 8 , , , cord-005453-4057qib7 12197 9 P=0.035 p=0.035 NN cord-005453-4057qib7 12197 10 ) ) -RRB- cord-005453-4057qib7 12197 11 . . . cord-005453-4057qib7 12198 1 The the DT cord-005453-4057qib7 12198 2 number number NN cord-005453-4057qib7 12198 3 of of IN cord-005453-4057qib7 12198 4 NK NK NNP cord-005453-4057qib7 12198 5 cells cell NNS cord-005453-4057qib7 12198 6 in in IN cord-005453-4057qib7 12198 7 1 1 CD cord-005453-4057qib7 12198 8 months month NNS cord-005453-4057qib7 12198 9 post post NN cord-005453-4057qib7 12198 10 - - JJ cord-005453-4057qib7 12198 11 HSCT HSCT NNP cord-005453-4057qib7 12198 12 was be VBD cord-005453-4057qib7 12198 13 significantly significantly RB cord-005453-4057qib7 12198 14 lower low JJR cord-005453-4057qib7 12198 15 in in IN cord-005453-4057qib7 12198 16 patients patient NNS cord-005453-4057qib7 12198 17 with with IN cord-005453-4057qib7 12198 18 CMV CMV NNP cord-005453-4057qib7 12198 19 reactivation reactivation NN cord-005453-4057qib7 12198 20 and and CC cord-005453-4057qib7 12198 21 acute acute JJ cord-005453-4057qib7 12198 22 GVHD GVHD NNP cord-005453-4057qib7 12198 23 compared compare VBN cord-005453-4057qib7 12198 24 to to IN cord-005453-4057qib7 12198 25 patients patient NNS cord-005453-4057qib7 12198 26 without without IN cord-005453-4057qib7 12198 27 ( ( -LRB- cord-005453-4057qib7 12199 1 258.5 258.5 CD cord-005453-4057qib7 12199 2 / / SYM cord-005453-4057qib7 12199 3 μL μl NN cord-005453-4057qib7 12199 4 vs. vs. IN cord-005453-4057qib7 12199 5 501.67 501.67 CD cord-005453-4057qib7 12200 1 /μL /μL NFP cord-005453-4057qib7 12200 2 , , , cord-005453-4057qib7 12200 3 P=0.004 P=0.004 NNP cord-005453-4057qib7 12200 4 , , , cord-005453-4057qib7 12200 5 and and CC cord-005453-4057qib7 12200 6 162.5 162.5 CD cord-005453-4057qib7 12201 1 /μL /μL NFP cord-005453-4057qib7 12201 2 vs. vs. IN cord-005453-4057qib7 12201 3 464.88/ 464.88/ CD cord-005453-4057qib7 12202 1 μL μL NNP cord-005453-4057qib7 12202 2 , , , cord-005453-4057qib7 12202 3 P=0.027 p=0.027 RB cord-005453-4057qib7 12202 4 , , , cord-005453-4057qib7 12202 5 respectively respectively RB cord-005453-4057qib7 12202 6 ) ) -RRB- cord-005453-4057qib7 12202 7 . . . cord-005453-4057qib7 12203 1 In in IN cord-005453-4057qib7 12203 2 multivariable multivariable JJ cord-005453-4057qib7 12203 3 analysis analysis NN cord-005453-4057qib7 12203 4 , , , cord-005453-4057qib7 12203 5 acute acute JJ cord-005453-4057qib7 12203 6 GVHD GVHD NNP cord-005453-4057qib7 12203 7 was be VBD cord-005453-4057qib7 12203 8 shown show VBN cord-005453-4057qib7 12203 9 to to TO cord-005453-4057qib7 12203 10 be be VB cord-005453-4057qib7 12203 11 the the DT cord-005453-4057qib7 12203 12 decisive decisive JJ cord-005453-4057qib7 12203 13 factor factor NN cord-005453-4057qib7 12203 14 influencing influence VBG cord-005453-4057qib7 12203 15 total total JJ cord-005453-4057qib7 12203 16 T t NN cord-005453-4057qib7 12203 17 cells cell NNS cord-005453-4057qib7 12203 18 ( ( -LRB- cord-005453-4057qib7 12203 19 P=0.028 p=0.028 NN cord-005453-4057qib7 12203 20 ) ) -RRB- cord-005453-4057qib7 12203 21 and and CC cord-005453-4057qib7 12203 22 CMV CMV NNP cord-005453-4057qib7 12203 23 reactivation reactivation NN cord-005453-4057qib7 12203 24 was be VBD cord-005453-4057qib7 12203 25 independently independently RB cord-005453-4057qib7 12203 26 associated associate VBN cord-005453-4057qib7 12203 27 with with IN cord-005453-4057qib7 12203 28 CD8 CD8 NNP cord-005453-4057qib7 12203 29 + + CC cord-005453-4057qib7 12203 30 T T NNP cord-005453-4057qib7 12203 31 cells cell NNS cord-005453-4057qib7 12203 32 ( ( -LRB- cord-005453-4057qib7 12203 33 P=0.026 P=0.026 NNP cord-005453-4057qib7 12203 34 ) ) -RRB- cord-005453-4057qib7 12203 35 . . . cord-005453-4057qib7 12204 1 The the DT cord-005453-4057qib7 12204 2 CD4 CD4 NNP cord-005453-4057qib7 12204 3 + + CC cord-005453-4057qib7 12204 4 T t NN cord-005453-4057qib7 12204 5 cells cell NNS cord-005453-4057qib7 12204 6 counts count NNS cord-005453-4057qib7 12204 7 were be VBD cord-005453-4057qib7 12204 8 associated associate VBN cord-005453-4057qib7 12204 9 with with IN cord-005453-4057qib7 12204 10 prior prior JJ cord-005453-4057qib7 12204 11 HSCT HSCT NNP cord-005453-4057qib7 12204 12 history history NN cord-005453-4057qib7 12204 13 and and CC cord-005453-4057qib7 12204 14 acute acute JJ cord-005453-4057qib7 12204 15 GVHD GVHD NNP cord-005453-4057qib7 12204 16 ( ( -LRB- cord-005453-4057qib7 12204 17 P=0.042 P=0.042 NNP cord-005453-4057qib7 12204 18 and and CC cord-005453-4057qib7 12204 19 P=0.038 P=0.038 NNP cord-005453-4057qib7 12204 20 ) ) -RRB- cord-005453-4057qib7 12204 21 , , , cord-005453-4057qib7 12204 22 and and CC cord-005453-4057qib7 12204 23 the the DT cord-005453-4057qib7 12204 24 CD8 CD8 NNP cord-005453-4057qib7 12204 25 + + CC cord-005453-4057qib7 12204 26 T T NNP cord-005453-4057qib7 12204 27 cells cell NNS cord-005453-4057qib7 12204 28 counts count NNS cord-005453-4057qib7 12204 29 were be VBD cord-005453-4057qib7 12204 30 also also RB cord-005453-4057qib7 12204 31 significantly significantly RB cord-005453-4057qib7 12204 32 associated associate VBN cord-005453-4057qib7 12204 33 with with IN cord-005453-4057qib7 12204 34 donor donor NN cord-005453-4057qib7 12204 35 type type NN cord-005453-4057qib7 12204 36 ( ( -LRB- cord-005453-4057qib7 12204 37 P=0.016 P=0.016 NNP cord-005453-4057qib7 12204 38 ) ) -RRB- cord-005453-4057qib7 12204 39 . . . cord-005453-4057qib7 12205 1 Conclusions conclusion NNS cord-005453-4057qib7 12205 2 : : : cord-005453-4057qib7 12206 1 Overall overall RB cord-005453-4057qib7 12206 2 , , , cord-005453-4057qib7 12206 3 our -PRON- PRP$ cord-005453-4057qib7 12206 4 study study NN cord-005453-4057qib7 12206 5 documents document NNS cord-005453-4057qib7 12206 6 that that WDT cord-005453-4057qib7 12206 7 immune immune JJ cord-005453-4057qib7 12206 8 reconstitution reconstitution NN cord-005453-4057qib7 12206 9 of of IN cord-005453-4057qib7 12206 10 CD4 CD4 NNP cord-005453-4057qib7 12206 11 + + CC cord-005453-4057qib7 12206 12 , , , cord-005453-4057qib7 12206 13 CD8 CD8 NNP cord-005453-4057qib7 12206 14 + + CC cord-005453-4057qib7 12206 15 T T NNP cord-005453-4057qib7 12206 16 cells cell NNS cord-005453-4057qib7 12206 17 and and CC cord-005453-4057qib7 12206 18 NK NK NNP cord-005453-4057qib7 12206 19 cells cell NNS cord-005453-4057qib7 12206 20 is be VBZ cord-005453-4057qib7 12206 21 strongly strongly RB cord-005453-4057qib7 12206 22 associated associate VBN cord-005453-4057qib7 12206 23 with with IN cord-005453-4057qib7 12206 24 CMV CMV NNP cord-005453-4057qib7 12206 25 reactivation reactivation NN cord-005453-4057qib7 12206 26 and and CC cord-005453-4057qib7 12206 27 acute acute JJ cord-005453-4057qib7 12206 28 GVHD GVHD NNP cord-005453-4057qib7 12206 29 . . . cord-005453-4057qib7 12207 1 Additionally additionally RB cord-005453-4057qib7 12207 2 , , , cord-005453-4057qib7 12207 3 we -PRON- PRP cord-005453-4057qib7 12207 4 show show VBP cord-005453-4057qib7 12207 5 that that IN cord-005453-4057qib7 12207 6 acute acute JJ cord-005453-4057qib7 12207 7 GVHD GVHD NNP cord-005453-4057qib7 12207 8 is be VBZ cord-005453-4057qib7 12207 9 influenced influence VBN cord-005453-4057qib7 12207 10 by by IN cord-005453-4057qib7 12207 11 lack lack NN cord-005453-4057qib7 12207 12 of of IN cord-005453-4057qib7 12207 13 sufficient sufficient JJ cord-005453-4057qib7 12207 14 numbers number NNS cord-005453-4057qib7 12207 15 of of IN cord-005453-4057qib7 12207 16 NK NK NNP cord-005453-4057qib7 12207 17 cells cell NNS cord-005453-4057qib7 12207 18 as as RB cord-005453-4057qib7 12207 19 well well RB cord-005453-4057qib7 12207 20 as as IN cord-005453-4057qib7 12207 21 CD4 CD4 NNP cord-005453-4057qib7 12207 22 + + CC cord-005453-4057qib7 12207 23 T T NNP cord-005453-4057qib7 12207 24 cells cell NNS cord-005453-4057qib7 12207 25 early early RB cord-005453-4057qib7 12207 26 after after IN cord-005453-4057qib7 12207 27 SCT SCT NNP cord-005453-4057qib7 12207 28 . . . cord-005453-4057qib7 12208 1 CD8 CD8 NNP cord-005453-4057qib7 12208 2 + + CC cord-005453-4057qib7 12208 3 T T NNP cord-005453-4057qib7 12208 4 cells cell NNS cord-005453-4057qib7 12208 5 , , , cord-005453-4057qib7 12208 6 on on IN cord-005453-4057qib7 12208 7 the the DT cord-005453-4057qib7 12208 8 other other JJ cord-005453-4057qib7 12208 9 hand hand NN cord-005453-4057qib7 12208 10 , , , cord-005453-4057qib7 12208 11 significantly significantly RB cord-005453-4057qib7 12208 12 increase increase VBP cord-005453-4057qib7 12208 13 after after IN cord-005453-4057qib7 12208 14 CMV cmv NN cord-005453-4057qib7 12208 15 - - HYPH cord-005453-4057qib7 12208 16 reactivation reactivation NN cord-005453-4057qib7 12208 17 and and CC cord-005453-4057qib7 12208 18 most most RBS cord-005453-4057qib7 12208 19 likely likely RB cord-005453-4057qib7 12208 20 play play VBP cord-005453-4057qib7 12208 21 an an DT cord-005453-4057qib7 12208 22 important important JJ cord-005453-4057qib7 12208 23 role role NN cord-005453-4057qib7 12208 24 in in IN cord-005453-4057qib7 12208 25 reactivation reactivation NN cord-005453-4057qib7 12208 26 . . . cord-005453-4057qib7 12209 1 Disclosure disclosure NN cord-005453-4057qib7 12209 2 : : : cord-005453-4057qib7 12209 3 Nothing nothing NN cord-005453-4057qib7 12209 4 to to TO cord-005453-4057qib7 12209 5 declare declare VB cord-005453-4057qib7 12209 6 Background background NN cord-005453-4057qib7 12209 7 : : : cord-005453-4057qib7 12209 8 Curative curative JJ cord-005453-4057qib7 12209 9 effect effect NN cord-005453-4057qib7 12209 10 of of IN cord-005453-4057qib7 12209 11 allogeneic allogeneic NN cord-005453-4057qib7 12209 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 12209 13 stem stem NN cord-005453-4057qib7 12209 14 cell cell NN cord-005453-4057qib7 12209 15 transplantation transplantation NN cord-005453-4057qib7 12209 16 ( ( -LRB- cord-005453-4057qib7 12209 17 allo allo NN cord-005453-4057qib7 12209 18 - - HYPH cord-005453-4057qib7 12209 19 HSCT HSCT NNP cord-005453-4057qib7 12209 20 ) ) -RRB- cord-005453-4057qib7 12209 21 depends depend VBZ cord-005453-4057qib7 12209 22 on on IN cord-005453-4057qib7 12209 23 the the DT cord-005453-4057qib7 12209 24 alloreactive alloreactive JJ cord-005453-4057qib7 12209 25 T t NN cord-005453-4057qib7 12209 26 - - HYPH cord-005453-4057qib7 12209 27 cell cell NN cord-005453-4057qib7 12209 28 immune immune JJ cord-005453-4057qib7 12209 29 response response NN cord-005453-4057qib7 12209 30 toward toward IN cord-005453-4057qib7 12209 31 residual residual JJ cord-005453-4057qib7 12209 32 malignant malignant JJ cord-005453-4057qib7 12209 33 cells cell NNS cord-005453-4057qib7 12210 1 -graft -graft NN cord-005453-4057qib7 12210 2 - - HYPH cord-005453-4057qib7 12210 3 versus versus IN cord-005453-4057qib7 12210 4 - - HYPH cord-005453-4057qib7 12210 5 leukemia leukemia NN cord-005453-4057qib7 12210 6 reaction reaction NN cord-005453-4057qib7 12210 7 . . . cord-005453-4057qib7 12211 1 However however RB cord-005453-4057qib7 12211 2 , , , cord-005453-4057qib7 12211 3 alloreactive alloreactive JJ cord-005453-4057qib7 12211 4 population population NN cord-005453-4057qib7 12211 5 has have VBZ cord-005453-4057qib7 12211 6 not not RB cord-005453-4057qib7 12211 7 been be VBN cord-005453-4057qib7 12211 8 phenotypically phenotypically RB cord-005453-4057qib7 12211 9 defined define VBN cord-005453-4057qib7 12211 10 . . . cord-005453-4057qib7 12212 1 Recent recent JJ cord-005453-4057qib7 12212 2 studies study NNS cord-005453-4057qib7 12212 3 suggest suggest VBP cord-005453-4057qib7 12212 4 that that IN cord-005453-4057qib7 12212 5 alloreactive alloreactive NNP cord-005453-4057qib7 12212 6 T T NNP cord-005453-4057qib7 12212 7 cells cell NNS cord-005453-4057qib7 12212 8 express express VBP cord-005453-4057qib7 12212 9 both both DT cord-005453-4057qib7 12212 10 costimulatory costimulatory JJ cord-005453-4057qib7 12212 11 and and CC cord-005453-4057qib7 12212 12 inhibitory inhibitory JJ cord-005453-4057qib7 12212 13 receptors receptor NNS cord-005453-4057qib7 12212 14 simultaneously simultaneously RB cord-005453-4057qib7 12212 15 . . . cord-005453-4057qib7 12213 1 Exhaustion exhaustion NN cord-005453-4057qib7 12213 2 caused cause VBN cord-005453-4057qib7 12213 3 by by IN cord-005453-4057qib7 12213 4 the the DT cord-005453-4057qib7 12213 5 inhibitory inhibitory JJ cord-005453-4057qib7 12213 6 signaling signaling NN cord-005453-4057qib7 12213 7 dampens dampen VBZ cord-005453-4057qib7 12213 8 Tcell Tcell NNP cord-005453-4057qib7 12213 9 functionality functionality NN cord-005453-4057qib7 12213 10 , , , cord-005453-4057qib7 12213 11 which which WDT cord-005453-4057qib7 12213 12 could could MD cord-005453-4057qib7 12213 13 lead lead VB cord-005453-4057qib7 12213 14 to to IN cord-005453-4057qib7 12213 15 the the DT cord-005453-4057qib7 12213 16 disease disease NN cord-005453-4057qib7 12213 17 relapse relapse VB cord-005453-4057qib7 12213 18 . . . cord-005453-4057qib7 12214 1 Here here RB cord-005453-4057qib7 12214 2 we -PRON- PRP cord-005453-4057qib7 12214 3 aimed aim VBD cord-005453-4057qib7 12214 4 to to TO cord-005453-4057qib7 12214 5 investigate investigate VB cord-005453-4057qib7 12214 6 the the DT cord-005453-4057qib7 12214 7 expression expression NN cord-005453-4057qib7 12214 8 of of IN cord-005453-4057qib7 12214 9 costimulatory costimulatory NN cord-005453-4057qib7 12214 10 and and CC cord-005453-4057qib7 12214 11 inhibitory inhibitory JJ cord-005453-4057qib7 12214 12 receptors receptor NNS cord-005453-4057qib7 12214 13 on on IN cord-005453-4057qib7 12214 14 antigen antigen NN cord-005453-4057qib7 12214 15 - - HYPH cord-005453-4057qib7 12214 16 experienced experience VBN cord-005453-4057qib7 12214 17 T T NNP cord-005453-4057qib7 12214 18 cells cell NNS cord-005453-4057qib7 12214 19 after after IN cord-005453-4057qib7 12214 20 transplantation transplantation NN cord-005453-4057qib7 12214 21 , , , cord-005453-4057qib7 12214 22 to to TO cord-005453-4057qib7 12214 23 isolate isolate VB cord-005453-4057qib7 12214 24 subpopulation subpopulation NN cord-005453-4057qib7 12214 25 specific specific JJ cord-005453-4057qib7 12214 26 for for IN cord-005453-4057qib7 12214 27 allo allo NN cord-005453-4057qib7 12214 28 - - HYPH cord-005453-4057qib7 12214 29 HSCT HSCT NNP cord-005453-4057qib7 12214 30 patients patient NNS cord-005453-4057qib7 12214 31 and and CC cord-005453-4057qib7 12214 32 analyze analyze VB cord-005453-4057qib7 12214 33 their -PRON- PRP$ cord-005453-4057qib7 12214 34 T t NN cord-005453-4057qib7 12214 35 - - HYPH cord-005453-4057qib7 12214 36 cell cell NN cord-005453-4057qib7 12214 37 receptor receptor NN cord-005453-4057qib7 12214 38 ( ( -LRB- cord-005453-4057qib7 12214 39 TCR TCR NNP cord-005453-4057qib7 12214 40 ) ) -RRB- cord-005453-4057qib7 12214 41 repertoire repertoire NN cord-005453-4057qib7 12214 42 . . . cord-005453-4057qib7 12215 1 Methods method NNS cord-005453-4057qib7 12215 2 : : : cord-005453-4057qib7 12215 3 Expression expression NN cord-005453-4057qib7 12215 4 of of IN cord-005453-4057qib7 12215 5 coinhibitory coinhibitory NNP cord-005453-4057qib7 12215 6 and and CC cord-005453-4057qib7 12215 7 costimulatory costimulatory NNP cord-005453-4057qib7 12215 8 molecules molecule NNS cord-005453-4057qib7 12215 9 on on IN cord-005453-4057qib7 12215 10 PBMCs pbmcs JJ cord-005453-4057qib7 12215 11 patients patient NNS cord-005453-4057qib7 12215 12 at at IN cord-005453-4057qib7 12215 13 various various JJ cord-005453-4057qib7 12215 14 time time NN cord-005453-4057qib7 12215 15 points point NNS cord-005453-4057qib7 12215 16 after after IN cord-005453-4057qib7 12215 17 allo allo NN cord-005453-4057qib7 12215 18 - - HYPH cord-005453-4057qib7 12215 19 HSCT HSCT NNP cord-005453-4057qib7 12215 20 was be VBD cord-005453-4057qib7 12215 21 analyzed analyze VBN cord-005453-4057qib7 12215 22 for for IN cord-005453-4057qib7 12215 23 expression expression NN cord-005453-4057qib7 12215 24 of of IN cord-005453-4057qib7 12215 25 : : : cord-005453-4057qib7 12215 26 CD3 CD3 NNP cord-005453-4057qib7 12215 27 , , , cord-005453-4057qib7 12215 28 CD8 CD8 NNP cord-005453-4057qib7 12215 29 , , , cord-005453-4057qib7 12215 30 CD4 CD4 NNP cord-005453-4057qib7 12215 31 , , , cord-005453-4057qib7 12215 32 CD45RA CD45RA NNP cord-005453-4057qib7 12215 33 , , , cord-005453-4057qib7 12215 34 CCR7 CCR7 NNP cord-005453-4057qib7 12215 35 , , , cord-005453-4057qib7 12215 36 CD95 CD95 NNP cord-005453-4057qib7 12215 37 , , , cord-005453-4057qib7 12215 38 CD27 CD27 NNP cord-005453-4057qib7 12215 39 , , , cord-005453-4057qib7 12215 40 CD28 CD28 NNP cord-005453-4057qib7 12215 41 , , , cord-005453-4057qib7 12215 42 KLRG1 klrg1 XX cord-005453-4057qib7 12215 43 , , , cord-005453-4057qib7 12215 44 TIGIT TIGIT NNP cord-005453-4057qib7 12215 45 , , , cord-005453-4057qib7 12215 46 PD1 PD1 NNP cord-005453-4057qib7 12215 47 , , , cord-005453-4057qib7 12215 48 CD137 CD137 NNP cord-005453-4057qib7 12215 49 and and CC cord-005453-4057qib7 12215 50 OX40 OX40 NNP cord-005453-4057qib7 12215 51 by by IN cord-005453-4057qib7 12215 52 flow flow NN cord-005453-4057qib7 12215 53 cytometry cytometry NN cord-005453-4057qib7 12215 54 and and CC cord-005453-4057qib7 12215 55 compared compare VBN cord-005453-4057qib7 12215 56 to to IN cord-005453-4057qib7 12215 57 healthy healthy JJ cord-005453-4057qib7 12215 58 donors donor NNS cord-005453-4057qib7 12215 59 . . . cord-005453-4057qib7 12216 1 CD3+CD8+CD95-CD27 CD3+CD8+CD95-CD27 NNP cord-005453-4057qib7 12216 2 + + . cord-005453-4057qib7 12217 1 CD28+PD1+TIGIT+ CD28+PD1+TIGIT+ NNP cord-005453-4057qib7 12217 2 fraction fraction NNP cord-005453-4057qib7 12217 3 and and CC cord-005453-4057qib7 12217 4 CD3 CD3 NNP cord-005453-4057qib7 12217 5 + + CC cord-005453-4057qib7 12217 6 CD8 CD8 NNP cord-005453-4057qib7 12218 1 + + CC cord-005453-4057qib7 12219 1 control control NN cord-005453-4057qib7 12219 2 fractions fraction NNS cord-005453-4057qib7 12219 3 were be VBD cord-005453-4057qib7 12219 4 separated separate VBN cord-005453-4057qib7 12219 5 on on IN cord-005453-4057qib7 12219 6 FACS FACS NNP cord-005453-4057qib7 12219 7 Aria Aria NNP cord-005453-4057qib7 12219 8 II II NNP cord-005453-4057qib7 12219 9 cell cell NN cord-005453-4057qib7 12219 10 sorter sorter NN cord-005453-4057qib7 12219 11 . . . cord-005453-4057qib7 12220 1 Double double JJ cord-005453-4057qib7 12220 2 barcoded barcoded JJ cord-005453-4057qib7 12220 3 cDNA cdna NN cord-005453-4057qib7 12220 4 libraries library NNS cord-005453-4057qib7 12220 5 of of IN cord-005453-4057qib7 12220 6 TCR TCR NNP cord-005453-4057qib7 12220 7 beta beta NN cord-005453-4057qib7 12220 8 - - HYPH cord-005453-4057qib7 12220 9 chains chain NNS cord-005453-4057qib7 12220 10 for for IN cord-005453-4057qib7 12220 11 both both DT cord-005453-4057qib7 12220 12 fractions fraction NNS cord-005453-4057qib7 12220 13 were be VBD cord-005453-4057qib7 12220 14 prepared prepare VBN cord-005453-4057qib7 12220 15 and and CC cord-005453-4057qib7 12220 16 analyzed analyze VBN cord-005453-4057qib7 12220 17 by by IN cord-005453-4057qib7 12220 18 sequencing sequence VBG cord-005453-4057qib7 12220 19 on on IN cord-005453-4057qib7 12220 20 Illumina Illumina NNP cord-005453-4057qib7 12220 21 platform platform NN cord-005453-4057qib7 12220 22 . . . cord-005453-4057qib7 12221 1 Sequencing sequencing NN cord-005453-4057qib7 12221 2 results result NNS cord-005453-4057qib7 12221 3 were be VBD cord-005453-4057qib7 12221 4 processed process VBN cord-005453-4057qib7 12221 5 by by IN cord-005453-4057qib7 12221 6 MiGEC MiGEC NNP cord-005453-4057qib7 12221 7 , , , cord-005453-4057qib7 12221 8 MiXCR MiXCR NNP cord-005453-4057qib7 12221 9 and and CC cord-005453-4057qib7 12221 10 VDJTools vdjtool VBZ cord-005453-4057qib7 12221 11 software software NN cord-005453-4057qib7 12221 12 . . . cord-005453-4057qib7 12222 1 Enriched enriched JJ cord-005453-4057qib7 12222 2 clones clone NNS cord-005453-4057qib7 12222 3 were be VBD cord-005453-4057qib7 12222 4 identified identify VBN cord-005453-4057qib7 12222 5 by by IN cord-005453-4057qib7 12222 6 Fisher Fisher NNP cord-005453-4057qib7 12222 7 's 's POS cord-005453-4057qib7 12222 8 exact exact JJ cord-005453-4057qib7 12222 9 test test NN cord-005453-4057qib7 12222 10 ( ( -LRB- cord-005453-4057qib7 12222 11 p>10 p>10 NN cord-005453-4057qib7 12222 12 -10 -10 CD cord-005453-4057qib7 12222 13 ) ) -RRB- cord-005453-4057qib7 12222 14 . . . cord-005453-4057qib7 12223 1 Results result NNS cord-005453-4057qib7 12223 2 : : : cord-005453-4057qib7 12224 1 We -PRON- PRP cord-005453-4057qib7 12224 2 did do VBD cord-005453-4057qib7 12224 3 not not RB cord-005453-4057qib7 12224 4 find find VB cord-005453-4057qib7 12224 5 any any DT cord-005453-4057qib7 12224 6 significant significant JJ cord-005453-4057qib7 12224 7 differences difference NNS cord-005453-4057qib7 12224 8 between between IN cord-005453-4057qib7 12224 9 patients patient NNS cord-005453-4057qib7 12224 10 after after IN cord-005453-4057qib7 12224 11 allo allo NN cord-005453-4057qib7 12224 12 - - HYPH cord-005453-4057qib7 12224 13 HSCT HSCT NNP cord-005453-4057qib7 12224 14 and and CC cord-005453-4057qib7 12224 15 healthy healthy JJ cord-005453-4057qib7 12224 16 donors donor NNS cord-005453-4057qib7 12224 17 in in IN cord-005453-4057qib7 12224 18 single single JJ cord-005453-4057qib7 12224 19 marker marker NN cord-005453-4057qib7 12224 20 's 's POS cord-005453-4057qib7 12224 21 expression expression NN cord-005453-4057qib7 12224 22 , , , cord-005453-4057qib7 12224 23 but but CC cord-005453-4057qib7 12224 24 , , , cord-005453-4057qib7 12224 25 when when WRB cord-005453-4057qib7 12224 26 considering consider VBG cord-005453-4057qib7 12224 27 coexpression coexpression NN cord-005453-4057qib7 12224 28 of of IN cord-005453-4057qib7 12224 29 co co JJ cord-005453-4057qib7 12224 30 - - JJ cord-005453-4057qib7 12224 31 stimulatory stimulatory JJ cord-005453-4057qib7 12224 32 and and CC cord-005453-4057qib7 12224 33 inhibitory inhibitory JJ cord-005453-4057qib7 12224 34 molecules molecule NNS cord-005453-4057qib7 12224 35 on on IN cord-005453-4057qib7 12224 36 T t NN cord-005453-4057qib7 12224 37 cells cell NNS cord-005453-4057qib7 12224 38 we -PRON- PRP cord-005453-4057qib7 12224 39 found find VBD cord-005453-4057qib7 12224 40 that that IN cord-005453-4057qib7 12224 41 CD3+CD8+CD95-CD27+CD28 CD3+CD8+CD95-CD27+CD28 NNP cord-005453-4057qib7 12224 42 + + SYM cord-005453-4057qib7 12224 43 PD1+TIGIT+ pd1+tigit+ NN cord-005453-4057qib7 12224 44 subpopulation subpopulation NN cord-005453-4057qib7 12224 45 was be VBD cord-005453-4057qib7 12224 46 significantly significantly RB cord-005453-4057qib7 12224 47 increased increase VBN cord-005453-4057qib7 12224 48 in in IN cord-005453-4057qib7 12224 49 allo allo NN cord-005453-4057qib7 12224 50 - - HYPH cord-005453-4057qib7 12224 51 HSCT HSCT NNP cord-005453-4057qib7 12224 52 patients patient NNS cord-005453-4057qib7 12224 53 . . . cord-005453-4057qib7 12225 1 Moreover moreover RB cord-005453-4057qib7 12225 2 it -PRON- PRP cord-005453-4057qib7 12225 3 increased increase VBD cord-005453-4057qib7 12225 4 with with IN cord-005453-4057qib7 12225 5 the the DT cord-005453-4057qib7 12225 6 time time NN cord-005453-4057qib7 12225 7 since since IN cord-005453-4057qib7 12225 8 the the DT cord-005453-4057qib7 12225 9 transplantation transplantation NN cord-005453-4057qib7 12225 10 ( ( -LRB- cord-005453-4057qib7 12225 11 Fig Fig NNP cord-005453-4057qib7 12225 12 . . . cord-005453-4057qib7 12225 13 1 1 CD cord-005453-4057qib7 12225 14 ) ) -RRB- cord-005453-4057qib7 12225 15 . . . cord-005453-4057qib7 12226 1 This this DT cord-005453-4057qib7 12226 2 population population NN cord-005453-4057qib7 12226 3 was be VBD cord-005453-4057qib7 12226 4 isolated isolate VBN cord-005453-4057qib7 12226 5 by by IN cord-005453-4057qib7 12226 6 cell cell NN cord-005453-4057qib7 12226 7 sorting sorting NN cord-005453-4057qib7 12226 8 and and CC cord-005453-4057qib7 12226 9 alongside alongside RB cord-005453-4057qib7 12226 10 with with IN cord-005453-4057qib7 12226 11 total total JJ cord-005453-4057qib7 12226 12 CD8 CD8 NNP cord-005453-4057qib7 12226 13 + + CC cord-005453-4057qib7 12226 14 fraction fraction NN cord-005453-4057qib7 12226 15 subjected subject VBN cord-005453-4057qib7 12226 16 to to IN cord-005453-4057qib7 12226 17 TCR TCR NNP cord-005453-4057qib7 12226 18 beta beta JJ cord-005453-4057qib7 12226 19 - - HYPH cord-005453-4057qib7 12226 20 chain chain NN cord-005453-4057qib7 12226 21 repertoire repertoire NN cord-005453-4057qib7 12226 22 sequencing sequencing NN cord-005453-4057qib7 12226 23 . . . cord-005453-4057qib7 12227 1 The the DT cord-005453-4057qib7 12227 2 population population NN cord-005453-4057qib7 12227 3 contained contain VBD cord-005453-4057qib7 12227 4 clones clone NNS cord-005453-4057qib7 12227 5 significantly significantly RB cord-005453-4057qib7 12227 6 enriched enrich VBN cord-005453-4057qib7 12227 7 compared compare VBN cord-005453-4057qib7 12227 8 with with IN cord-005453-4057qib7 12227 9 CD8 CD8 NNP cord-005453-4057qib7 12227 10 + + CC cord-005453-4057qib7 12227 11 fraction fraction NN cord-005453-4057qib7 12227 12 representing represent VBG cord-005453-4057qib7 12227 13 potentially potentially RB cord-005453-4057qib7 12227 14 alloreactive alloreactive JJ cord-005453-4057qib7 12227 15 cells cell NNS cord-005453-4057qib7 12227 16 . . . cord-005453-4057qib7 12228 1 This this DT cord-005453-4057qib7 12228 2 hypothesis hypothesis NN cord-005453-4057qib7 12228 3 is be VBZ cord-005453-4057qib7 12228 4 further further RB cord-005453-4057qib7 12228 5 supported support VBN cord-005453-4057qib7 12228 6 by by IN cord-005453-4057qib7 12228 7 the the DT cord-005453-4057qib7 12228 8 notion notion NN cord-005453-4057qib7 12228 9 that that IN cord-005453-4057qib7 12228 10 the the DT cord-005453-4057qib7 12228 11 level level NN cord-005453-4057qib7 12228 12 of of IN cord-005453-4057qib7 12228 13 expression expression NN cord-005453-4057qib7 12228 14 of of IN cord-005453-4057qib7 12228 15 CD27 CD27 NNP cord-005453-4057qib7 12228 16 and and CC cord-005453-4057qib7 12228 17 CD28 CD28 NNP cord-005453-4057qib7 12228 18 co co VBD cord-005453-4057qib7 12228 19 - - JJ cord-005453-4057qib7 12228 20 stimulatory stimulatory JJ cord-005453-4057qib7 12228 21 molecules molecule NNS cord-005453-4057qib7 12228 22 is be VBZ cord-005453-4057qib7 12228 23 lower low JJR cord-005453-4057qib7 12228 24 in in IN cord-005453-4057qib7 12228 25 the the DT cord-005453-4057qib7 12228 26 group group NN cord-005453-4057qib7 12228 27 of of IN cord-005453-4057qib7 12228 28 patients patient NNS cord-005453-4057qib7 12228 29 who who WP cord-005453-4057qib7 12228 30 subsequently subsequently RB cord-005453-4057qib7 12228 31 relapsed relapse VBD cord-005453-4057qib7 12228 32 , , , cord-005453-4057qib7 12228 33 compared compare VBN cord-005453-4057qib7 12228 34 with with IN cord-005453-4057qib7 12228 35 the the DT cord-005453-4057qib7 12228 36 patients patient NNS cord-005453-4057qib7 12228 37 with with IN cord-005453-4057qib7 12228 38 complete complete JJ cord-005453-4057qib7 12228 39 remission remission NN cord-005453-4057qib7 12228 40 , , , cord-005453-4057qib7 12228 41 while while IN cord-005453-4057qib7 12228 42 the the DT cord-005453-4057qib7 12228 43 expression expression NN cord-005453-4057qib7 12228 44 of of IN cord-005453-4057qib7 12228 45 inhibitory inhibitory JJ cord-005453-4057qib7 12228 46 receptors receptor NNS cord-005453-4057qib7 12228 47 was be VBD cord-005453-4057qib7 12228 48 high high JJ cord-005453-4057qib7 12228 49 in in IN cord-005453-4057qib7 12228 50 both both DT cord-005453-4057qib7 12228 51 groups group NNS cord-005453-4057qib7 12228 52 . . . cord-005453-4057qib7 12229 1 Conclusions conclusion NNS cord-005453-4057qib7 12229 2 : : : cord-005453-4057qib7 12230 1 According accord VBG cord-005453-4057qib7 12230 2 to to IN cord-005453-4057qib7 12230 3 our -PRON- PRP$ cord-005453-4057qib7 12230 4 data data NN cord-005453-4057qib7 12230 5 patients patient NNS cord-005453-4057qib7 12230 6 after after IN cord-005453-4057qib7 12230 7 allo allo NN cord-005453-4057qib7 12230 8 - - HYPH cord-005453-4057qib7 12230 9 HSCT HSCT NNP cord-005453-4057qib7 12230 10 have have VBP cord-005453-4057qib7 12230 11 a a DT cord-005453-4057qib7 12230 12 phenotypically phenotypically RB cord-005453-4057qib7 12230 13 distinct distinct JJ cord-005453-4057qib7 12230 14 T t NN cord-005453-4057qib7 12230 15 - - HYPH cord-005453-4057qib7 12230 16 cell cell NN cord-005453-4057qib7 12230 17 population population NN cord-005453-4057qib7 12230 18 characterized characterize VBN cord-005453-4057qib7 12230 19 by by IN cord-005453-4057qib7 12230 20 simultaneous simultaneous JJ cord-005453-4057qib7 12230 21 expression expression NN cord-005453-4057qib7 12230 22 of of IN cord-005453-4057qib7 12230 23 costimulatory costimulatory NN cord-005453-4057qib7 12230 24 and and CC cord-005453-4057qib7 12230 25 inhibitory inhibitory JJ cord-005453-4057qib7 12230 26 markers marker NNS cord-005453-4057qib7 12230 27 . . . cord-005453-4057qib7 12231 1 This this DT cord-005453-4057qib7 12231 2 population population NN cord-005453-4057qib7 12231 3 contains contain VBZ cord-005453-4057qib7 12231 4 specifically specifically RB cord-005453-4057qib7 12231 5 enriched enrich VBN cord-005453-4057qib7 12231 6 clones clone NNS cord-005453-4057qib7 12231 7 , , , cord-005453-4057qib7 12231 8 which which WDT cord-005453-4057qib7 12231 9 may may MD cord-005453-4057qib7 12231 10 be be VB cord-005453-4057qib7 12231 11 specific specific JJ cord-005453-4057qib7 12231 12 for for IN cord-005453-4057qib7 12231 13 alloantigens alloantigens NNP cord-005453-4057qib7 12231 14 . . . cord-005453-4057qib7 12232 1 Further further JJ cord-005453-4057qib7 12232 2 functional functional JJ cord-005453-4057qib7 12232 3 assays assay NNS cord-005453-4057qib7 12232 4 are be VBP cord-005453-4057qib7 12232 5 needed need VBN cord-005453-4057qib7 12232 6 to to TO cord-005453-4057qib7 12232 7 confirm confirm VB cord-005453-4057qib7 12232 8 the the DT cord-005453-4057qib7 12232 9 alloreactive alloreactive JJ cord-005453-4057qib7 12232 10 potential potential NN cord-005453-4057qib7 12232 11 of of IN cord-005453-4057qib7 12232 12 this this DT cord-005453-4057qib7 12232 13 subpopulation subpopulation NN cord-005453-4057qib7 12232 14 . . . cord-005453-4057qib7 12233 1 Besides besides IN cord-005453-4057qib7 12233 2 low low JJ cord-005453-4057qib7 12233 3 expression expression NN cord-005453-4057qib7 12233 4 of of IN cord-005453-4057qib7 12233 5 costimulatory costimulatory NN cord-005453-4057qib7 12233 6 molecules molecule NNS cord-005453-4057qib7 12233 7 combined combine VBN cord-005453-4057qib7 12233 8 with with IN cord-005453-4057qib7 12233 9 high high JJ cord-005453-4057qib7 12233 10 expression expression NN cord-005453-4057qib7 12233 11 of of IN cord-005453-4057qib7 12233 12 inhibitory inhibitory JJ cord-005453-4057qib7 12233 13 receptors receptor NNS cord-005453-4057qib7 12233 14 on on IN cord-005453-4057qib7 12233 15 antigen antigen NN cord-005453-4057qib7 12233 16 - - HYPH cord-005453-4057qib7 12233 17 experienced experience VBN cord-005453-4057qib7 12233 18 T t NN cord-005453-4057qib7 12233 19 - - HYPH cord-005453-4057qib7 12233 20 cells cell NNS cord-005453-4057qib7 12233 21 of of IN cord-005453-4057qib7 12233 22 patients patient NNS cord-005453-4057qib7 12233 23 after after IN cord-005453-4057qib7 12233 24 allo allo NN cord-005453-4057qib7 12233 25 - - HYPH cord-005453-4057qib7 12233 26 HSCT HSCT NNP cord-005453-4057qib7 12233 27 might may MD cord-005453-4057qib7 12233 28 be be VB cord-005453-4057qib7 12233 29 associated associate VBN cord-005453-4057qib7 12233 30 with with IN cord-005453-4057qib7 12233 31 a a DT cord-005453-4057qib7 12233 32 disease disease NN cord-005453-4057qib7 12233 33 relapse relapse NN cord-005453-4057qib7 12233 34 . . . cord-005453-4057qib7 12234 1 Fondazione Fondazione NNP cord-005453-4057qib7 12234 2 MBBM MBBM NNP cord-005453-4057qib7 12234 3 , , , cord-005453-4057qib7 12234 4 Monza Monza NNP cord-005453-4057qib7 12234 5 , , , cord-005453-4057qib7 12234 6 Italy Italy NNP cord-005453-4057qib7 12234 7 , , , cord-005453-4057qib7 12234 8 3 3 CD cord-005453-4057qib7 12234 9 Ospedale Ospedale NNP cord-005453-4057qib7 12234 10 San San NNP cord-005453-4057qib7 12234 11 Gerardo Gerardo NNP cord-005453-4057qib7 12234 12 , , , cord-005453-4057qib7 12234 13 Laboratorio Laboratorio NNP cord-005453-4057qib7 12234 14 Stefano Stefano NNP cord-005453-4057qib7 12234 15 Verri Verri NNP cord-005453-4057qib7 12234 16 , , , cord-005453-4057qib7 12234 17 Monza Monza NNP cord-005453-4057qib7 12234 18 , , , cord-005453-4057qib7 12234 19 Italy Italy NNP cord-005453-4057qib7 12234 20 Background Background NNP cord-005453-4057qib7 12234 21 : : : cord-005453-4057qib7 12234 22 Poor poor JJ cord-005453-4057qib7 12234 23 graft graft NN cord-005453-4057qib7 12234 24 function function NN cord-005453-4057qib7 12234 25 ( ( -LRB- cord-005453-4057qib7 12234 26 PGF PGF NNP cord-005453-4057qib7 12234 27 ) ) -RRB- cord-005453-4057qib7 12234 28 is be VBZ cord-005453-4057qib7 12234 29 a a DT cord-005453-4057qib7 12234 30 severe severe JJ cord-005453-4057qib7 12234 31 complication complication NN cord-005453-4057qib7 12234 32 after after IN cord-005453-4057qib7 12234 33 HSCT HSCT NNP cord-005453-4057qib7 12234 34 , , , cord-005453-4057qib7 12234 35 with with IN cord-005453-4057qib7 12234 36 a a DT cord-005453-4057qib7 12234 37 high high JJ cord-005453-4057qib7 12234 38 risk risk NN cord-005453-4057qib7 12234 39 of of IN cord-005453-4057qib7 12234 40 morbidity morbidity NN cord-005453-4057qib7 12234 41 and and CC cord-005453-4057qib7 12234 42 mortality mortality NN cord-005453-4057qib7 12234 43 , , , cord-005453-4057qib7 12234 44 mainly mainly RB cord-005453-4057qib7 12234 45 due due IN cord-005453-4057qib7 12234 46 to to IN cord-005453-4057qib7 12234 47 infections infection NNS cord-005453-4057qib7 12234 48 . . . cord-005453-4057qib7 12235 1 Donor Donor NNP cord-005453-4057qib7 12235 2 CD34 CD34 NNP cord-005453-4057qib7 12235 3 + + CC cord-005453-4057qib7 12235 4 SCB SCB NNP cord-005453-4057qib7 12235 5 seems seem VBZ cord-005453-4057qib7 12235 6 to to TO cord-005453-4057qib7 12235 7 offer offer VB cord-005453-4057qib7 12235 8 high high JJ cord-005453-4057qib7 12235 9 chances chance NNS cord-005453-4057qib7 12235 10 of of IN cord-005453-4057qib7 12235 11 haematological haematological NN cord-005453-4057qib7 12235 12 recovery recovery NN cord-005453-4057qib7 12235 13 , , , cord-005453-4057qib7 12235 14 not not RB cord-005453-4057qib7 12235 15 jeopardized jeopardize VBN cord-005453-4057qib7 12235 16 by by IN cord-005453-4057qib7 12235 17 GvHD GvHD NNP cord-005453-4057qib7 12235 18 . . . cord-005453-4057qib7 12236 1 However however RB cord-005453-4057qib7 12236 2 , , , cord-005453-4057qib7 12236 3 pediatric pediatric JJ cord-005453-4057qib7 12236 4 reports report NNS cord-005453-4057qib7 12236 5 remain remain VBP cord-005453-4057qib7 12236 6 scarce scarce JJ cord-005453-4057qib7 12236 7 . . . cord-005453-4057qib7 12237 1 Methods method NNS cord-005453-4057qib7 12237 2 : : : cord-005453-4057qib7 12237 3 19 19 CD cord-005453-4057qib7 12237 4 out out IN cord-005453-4057qib7 12237 5 of of IN cord-005453-4057qib7 12237 6 215 215 CD cord-005453-4057qib7 12237 7 patients patient NNS cord-005453-4057qib7 12237 8 undergoing undergo VBG cord-005453-4057qib7 12237 9 transplantation transplantation NN cord-005453-4057qib7 12237 10 in in IN cord-005453-4057qib7 12237 11 our -PRON- PRP$ cord-005453-4057qib7 12237 12 pediatric pediatric JJ cord-005453-4057qib7 12237 13 unit unit NN cord-005453-4057qib7 12237 14 from from IN cord-005453-4057qib7 12237 15 2012 2012 CD cord-005453-4057qib7 12237 16 to to IN cord-005453-4057qib7 12237 17 2018 2018 CD cord-005453-4057qib7 12237 18 have have VBP cord-005453-4057qib7 12237 19 been be VBN cord-005453-4057qib7 12237 20 retrospectively retrospectively RB cord-005453-4057qib7 12237 21 evaluated evaluate VBN cord-005453-4057qib7 12237 22 for for IN cord-005453-4057qib7 12237 23 at at RB cord-005453-4057qib7 12237 24 least least JJS cord-005453-4057qib7 12237 25 2 2 CD cord-005453-4057qib7 12237 26 line line NN cord-005453-4057qib7 12237 27 persistent persistent JJ cord-005453-4057qib7 12237 28 cytopenia cytopenia NNS cord-005453-4057qib7 12237 29 ( ( -LRB- cord-005453-4057qib7 12237 30 Hb Hb NNP cord-005453-4057qib7 12237 31 < < XX cord-005453-4057qib7 12237 32 9.5g 9.5g CD cord-005453-4057qib7 12237 33 / / SYM cord-005453-4057qib7 12237 34 dl dl NN cord-005453-4057qib7 12237 35 , , , cord-005453-4057qib7 12237 36 PLT PLT NNP cord-005453-4057qib7 12237 37 < < XX cord-005453-4057qib7 12237 38 30000 30000 CD cord-005453-4057qib7 12237 39 / / SYM cord-005453-4057qib7 12237 40 mmc mmc NN cord-005453-4057qib7 12237 41 , , , cord-005453-4057qib7 12237 42 N N NNP cord-005453-4057qib7 12237 43 < < XX cord-005453-4057qib7 12237 44 1000/ 1000/ CD cord-005453-4057qib7 12237 45 mmc mmc NNS cord-005453-4057qib7 12237 46 ) ) -RRB- cord-005453-4057qib7 12237 47 and/or and/or CC cord-005453-4057qib7 12237 48 transfusion transfusion NN cord-005453-4057qib7 12237 49 - - HYPH cord-005453-4057qib7 12237 50 dependency dependency NN cord-005453-4057qib7 12237 51 beyond beyond IN cord-005453-4057qib7 12237 52 3 3 CD cord-005453-4057qib7 12237 53 months month NNS cord-005453-4057qib7 12237 54 after after IN cord-005453-4057qib7 12237 55 HSCT HSCT NNP cord-005453-4057qib7 12237 56 in in IN cord-005453-4057qib7 12237 57 the the DT cord-005453-4057qib7 12237 58 presence presence NN cord-005453-4057qib7 12237 59 of of IN cord-005453-4057qib7 12237 60 full full JJ cord-005453-4057qib7 12237 61 donor donor NN cord-005453-4057qib7 12237 62 chimerism chimerism NN cord-005453-4057qib7 12237 63 . . . cord-005453-4057qib7 12238 1 Bone bone NN cord-005453-4057qib7 12238 2 marrow marrow NN cord-005453-4057qib7 12238 3 cellularity cellularity NN cord-005453-4057qib7 12238 4 was be VBD cord-005453-4057qib7 12238 5 evaluated evaluate VBN cord-005453-4057qib7 12238 6 through through IN cord-005453-4057qib7 12238 7 biopsy biopsy NN cord-005453-4057qib7 12238 8 as as IN cord-005453-4057qib7 12238 9 further further JJ cord-005453-4057qib7 12238 10 indicator indicator NN cord-005453-4057qib7 12238 11 of of IN cord-005453-4057qib7 12238 12 PGF PGF NNP cord-005453-4057qib7 12238 13 . . . cord-005453-4057qib7 12239 1 ( ( -LRB- cord-005453-4057qib7 12239 2 1/8 1/8 CD cord-005453-4057qib7 12239 3 ) ) -RRB- cord-005453-4057qib7 12239 4 to to TO cord-005453-4057qib7 12239 5 donate donate VB cord-005453-4057qib7 12239 6 or or CC cord-005453-4057qib7 12239 7 medical medical JJ cord-005453-4057qib7 12239 8 decision decision NN cord-005453-4057qib7 12239 9 ( ( -LRB- cord-005453-4057qib7 12239 10 7/8 7/8 CD cord-005453-4057qib7 12239 11 ) ) -RRB- cord-005453-4057qib7 12239 12 . . . cord-005453-4057qib7 12240 1 Bone bone NN cord-005453-4057qib7 12240 2 marrow marrow NN cord-005453-4057qib7 12240 3 cellularity cellularity NN cord-005453-4057qib7 12240 4 was be VBD cord-005453-4057qib7 12240 5 < < XX cord-005453-4057qib7 12240 6 5 5 CD cord-005453-4057qib7 12240 7 % % NN cord-005453-4057qib7 12240 8 in in IN cord-005453-4057qib7 12240 9 50 50 CD cord-005453-4057qib7 12240 10 % % NN cord-005453-4057qib7 12240 11 of of IN cord-005453-4057qib7 12240 12 the the DT cord-005453-4057qib7 12240 13 patients patient NNS cord-005453-4057qib7 12240 14 who who WP cord-005453-4057qib7 12240 15 underwent undergo VBD cord-005453-4057qib7 12240 16 SCB SCB NNP cord-005453-4057qib7 12240 17 for for IN cord-005453-4057qib7 12240 18 which which WDT cord-005453-4057qib7 12240 19 the the DT cord-005453-4057qib7 12240 20 histology histology NN cord-005453-4057qib7 12240 21 was be VBD cord-005453-4057qib7 12240 22 available available JJ cord-005453-4057qib7 12240 23 ( ( -LRB- cord-005453-4057qib7 12240 24 8 8 CD cord-005453-4057qib7 12240 25 cases case NNS cord-005453-4057qib7 12240 26 ) ) -RRB- cord-005453-4057qib7 12240 27 , , , cord-005453-4057qib7 12240 28 and and CC cord-005453-4057qib7 12240 29 25 25 CD cord-005453-4057qib7 12240 30 % % NN cord-005453-4057qib7 12240 31 in in IN cord-005453-4057qib7 12240 32 those those DT cord-005453-4057qib7 12240 33 who who WP cord-005453-4057qib7 12240 34 have have VBP cord-005453-4057qib7 12240 35 not not RB cord-005453-4057qib7 12240 36 been be VBN cord-005453-4057qib7 12240 37 treated treat VBN cord-005453-4057qib7 12240 38 ( ( -LRB- cord-005453-4057qib7 12240 39 2/8 2/8 CD cord-005453-4057qib7 12240 40 ) ) -RRB- cord-005453-4057qib7 12240 41 . . . cord-005453-4057qib7 12241 1 At at IN cord-005453-4057qib7 12241 2 30 30 CD cord-005453-4057qib7 12241 3 days day NNS cord-005453-4057qib7 12241 4 after after IN cord-005453-4057qib7 12241 5 SCB SCB NNP cord-005453-4057qib7 12241 6 10/11 10/11 CD cord-005453-4057qib7 12241 7 ( ( -LRB- cord-005453-4057qib7 12241 8 91 91 CD cord-005453-4057qib7 12241 9 % % NN cord-005453-4057qib7 12241 10 ) ) -RRB- cord-005453-4057qib7 12241 11 patients patient NNS cord-005453-4057qib7 12241 12 had have VBD cord-005453-4057qib7 12241 13 hematological hematological JJ cord-005453-4057qib7 12241 14 response response NN cord-005453-4057qib7 12241 15 , , , cord-005453-4057qib7 12241 16 which which WDT cord-005453-4057qib7 12241 17 was be VBD cord-005453-4057qib7 12241 18 complete complete JJ cord-005453-4057qib7 12241 19 in in IN cord-005453-4057qib7 12241 20 46 46 CD cord-005453-4057qib7 12241 21 % % NN cord-005453-4057qib7 12241 22 and and CC cord-005453-4057qib7 12241 23 partial partial JJ cord-005453-4057qib7 12241 24 in in IN cord-005453-4057qib7 12241 25 45 45 CD cord-005453-4057qib7 12241 26 % % NN cord-005453-4057qib7 12241 27 of of IN cord-005453-4057qib7 12241 28 the the DT cord-005453-4057qib7 12241 29 patients patient NNS cord-005453-4057qib7 12241 30 . . . cord-005453-4057qib7 12242 1 Only only RB cord-005453-4057qib7 12242 2 1 1 CD cord-005453-4057qib7 12242 3 patient patient NN cord-005453-4057qib7 12242 4 had have VBD cord-005453-4057qib7 12242 5 no no DT cord-005453-4057qib7 12242 6 response response NN cord-005453-4057qib7 12242 7 . . . cord-005453-4057qib7 12243 1 The the DT cord-005453-4057qib7 12243 2 infusion infusion NN cord-005453-4057qib7 12243 3 was be VBD cord-005453-4057qib7 12243 4 always always RB cord-005453-4057qib7 12243 5 well well RB cord-005453-4057qib7 12243 6 tolerated tolerate VBN cord-005453-4057qib7 12243 7 with with IN cord-005453-4057qib7 12243 8 no no DT cord-005453-4057qib7 12243 9 adverse adverse JJ cord-005453-4057qib7 12243 10 events event NNS cord-005453-4057qib7 12243 11 , , , cord-005453-4057qib7 12243 12 and and CC cord-005453-4057qib7 12243 13 no no DT cord-005453-4057qib7 12243 14 worsening worsening NN cord-005453-4057qib7 12243 15 of of IN cord-005453-4057qib7 12243 16 GvHD GvHD NNP cord-005453-4057qib7 12243 17 . . . cord-005453-4057qib7 12244 1 Haematological Haematological NNP cord-005453-4057qib7 12244 2 recovery recovery NN cord-005453-4057qib7 12244 3 occurred occur VBD cord-005453-4057qib7 12244 4 spontaneously spontaneously RB cord-005453-4057qib7 12244 5 at at IN cord-005453-4057qib7 12244 6 30 30 CD cord-005453-4057qib7 12244 7 days day NNS cord-005453-4057qib7 12244 8 after after IN cord-005453-4057qib7 12244 9 bone bone NN cord-005453-4057qib7 12244 10 marrow marrow NN cord-005453-4057qib7 12244 11 biopsy biopsy NN cord-005453-4057qib7 12244 12 in in IN cord-005453-4057qib7 12244 13 a a DT cord-005453-4057qib7 12244 14 significantly significantly RB cord-005453-4057qib7 12244 15 lower low JJR cord-005453-4057qib7 12244 16 proportion proportion NN cord-005453-4057qib7 12244 17 of of IN cord-005453-4057qib7 12244 18 patients patient NNS cord-005453-4057qib7 12244 19 ( ( -LRB- cord-005453-4057qib7 12244 20 2/8 2/8 CD cord-005453-4057qib7 12244 21 , , , cord-005453-4057qib7 12244 22 25 25 CD cord-005453-4057qib7 12244 23 % % NN cord-005453-4057qib7 12244 24 , , , cord-005453-4057qib7 12244 25 p p NN cord-005453-4057qib7 12244 26 < < XX cord-005453-4057qib7 12244 27 0.05 0.05 CD cord-005453-4057qib7 12244 28 ) ) -RRB- cord-005453-4057qib7 12244 29 within within IN cord-005453-4057qib7 12244 30 the the DT cord-005453-4057qib7 12244 31 non non JJ cord-005453-4057qib7 12244 32 - - JJ cord-005453-4057qib7 12244 33 SCB SCB NNP cord-005453-4057qib7 12244 34 group group NN cord-005453-4057qib7 12244 35 . . . cord-005453-4057qib7 12245 1 In in IN cord-005453-4057qib7 12245 2 two two CD cord-005453-4057qib7 12245 3 cases case NNS cord-005453-4057qib7 12245 4 platelets platelet NNS cord-005453-4057qib7 12245 5 engraftment engraftment NN cord-005453-4057qib7 12245 6 was be VBD cord-005453-4057qib7 12245 7 significantly significantly RB cord-005453-4057qib7 12245 8 delayed delay VBN cord-005453-4057qib7 12245 9 , , , cord-005453-4057qib7 12245 10 up up IN cord-005453-4057qib7 12245 11 to to IN cord-005453-4057qib7 12245 12 one one CD cord-005453-4057qib7 12245 13 year year NN cord-005453-4057qib7 12245 14 after after IN cord-005453-4057qib7 12245 15 bone bone NN cord-005453-4057qib7 12245 16 marrow marrow NN cord-005453-4057qib7 12245 17 biopsy biopsy NN cord-005453-4057qib7 12245 18 and and CC cord-005453-4057qib7 12245 19 in in IN cord-005453-4057qib7 12245 20 one one CD cord-005453-4057qib7 12245 21 case case NN cord-005453-4057qib7 12245 22 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 12245 23 persists persist VBZ cord-005453-4057qib7 12245 24 and and CC cord-005453-4057qib7 12245 25 the the DT cord-005453-4057qib7 12245 26 patient patient NN cord-005453-4057qib7 12245 27 is be VBZ cord-005453-4057qib7 12245 28 still still RB cord-005453-4057qib7 12245 29 receiving receive VBG cord-005453-4057qib7 12245 30 thrombopoietin thrombopoietin NNP cord-005453-4057qib7 12245 31 agonists agonist NNS cord-005453-4057qib7 12245 32 and and CC cord-005453-4057qib7 12245 33 red red JJ cord-005453-4057qib7 12245 34 blood blood NN cord-005453-4057qib7 12245 35 cells cell NNS cord-005453-4057qib7 12245 36 transfusions transfusion NNS cord-005453-4057qib7 12245 37 at at IN cord-005453-4057qib7 12245 38 9 9 CD cord-005453-4057qib7 12245 39 months month NNS cord-005453-4057qib7 12245 40 after after IN cord-005453-4057qib7 12245 41 bone bone NN cord-005453-4057qib7 12245 42 marrow marrow NN cord-005453-4057qib7 12245 43 biopsy biopsy NN cord-005453-4057qib7 12245 44 . . . cord-005453-4057qib7 12246 1 Conclusions conclusion NNS cord-005453-4057qib7 12246 2 : : : cord-005453-4057qib7 12247 1 A a DT cord-005453-4057qib7 12247 2 stem stem NN cord-005453-4057qib7 12247 3 cell cell NN cord-005453-4057qib7 12247 4 boost boost NN cord-005453-4057qib7 12247 5 matched match VBD cord-005453-4057qib7 12247 6 the the DT cord-005453-4057qib7 12247 7 goal goal NN cord-005453-4057qib7 12247 8 to to TO cord-005453-4057qib7 12247 9 yield yield VB cord-005453-4057qib7 12247 10 count count NN cord-005453-4057qib7 12247 11 recovery recovery NN cord-005453-4057qib7 12247 12 in in IN cord-005453-4057qib7 12247 13 our -PRON- PRP$ cord-005453-4057qib7 12247 14 cohort cohort NN cord-005453-4057qib7 12247 15 . . . cord-005453-4057qib7 12248 1 Viral viral JJ cord-005453-4057qib7 12248 2 infections infection NNS cord-005453-4057qib7 12248 3 and and CC cord-005453-4057qib7 12248 4 GvHD GvHD NNP cord-005453-4057qib7 12248 5 may may MD cord-005453-4057qib7 12248 6 be be VB cord-005453-4057qib7 12248 7 possible possible JJ cord-005453-4057qib7 12248 8 risk risk NN cord-005453-4057qib7 12248 9 factors factor NNS cord-005453-4057qib7 12248 10 for for IN cord-005453-4057qib7 12248 11 PGF.Bilinear PGF.Bilinear NNP cord-005453-4057qib7 12248 12 or or CC cord-005453-4057qib7 12248 13 trilinear trilinear NN cord-005453-4057qib7 12248 14 cytopenia cytopenia NNP cord-005453-4057qib7 12248 15 with with IN cord-005453-4057qib7 12248 16 transfusion transfusion NN cord-005453-4057qib7 12248 17 dependency dependency NN cord-005453-4057qib7 12248 18 and and CC cord-005453-4057qib7 12248 19 BOM BOM NNP cord-005453-4057qib7 12248 20 cellularity cellularity NNP cord-005453-4057qib7 12248 21 < < XX cord-005453-4057qib7 12248 22 5 5 CD cord-005453-4057qib7 12248 23 % % NN cord-005453-4057qib7 12248 24 and and CC cord-005453-4057qib7 12248 25 full full JJ cord-005453-4057qib7 12248 26 donor donor NN cord-005453-4057qib7 12248 27 chimerism chimerism NN cord-005453-4057qib7 12248 28 are be VBP cord-005453-4057qib7 12248 29 good good JJ cord-005453-4057qib7 12248 30 indications indication NNS cord-005453-4057qib7 12248 31 for for IN cord-005453-4057qib7 12248 32 SCB SCB NNP cord-005453-4057qib7 12248 33 , , , cord-005453-4057qib7 12248 34 that that WDT cord-005453-4057qib7 12248 35 can can MD cord-005453-4057qib7 12248 36 provide provide VB cord-005453-4057qib7 12248 37 a a DT cord-005453-4057qib7 12248 38 significantly significantly RB cord-005453-4057qib7 12248 39 earlier early JJR cord-005453-4057qib7 12248 40 hematological hematological JJ cord-005453-4057qib7 12248 41 reconstitution reconstitution NN cord-005453-4057qib7 12248 42 , , , cord-005453-4057qib7 12248 43 without without IN cord-005453-4057qib7 12248 44 risks risk NNS cord-005453-4057qib7 12248 45 of of IN cord-005453-4057qib7 12248 46 GvHD GvHD NNP cord-005453-4057qib7 12248 47 . . . cord-005453-4057qib7 12249 1 Due due IN cord-005453-4057qib7 12249 2 to to IN cord-005453-4057qib7 12249 3 the the DT cord-005453-4057qib7 12249 4 proved prove VBN cord-005453-4057qib7 12249 5 early early JJ cord-005453-4057qib7 12249 6 efficacy efficacy NN cord-005453-4057qib7 12249 7 and and CC cord-005453-4057qib7 12249 8 safety safety NN cord-005453-4057qib7 12249 9 of of IN cord-005453-4057qib7 12249 10 CD34 CD34 NNP cord-005453-4057qib7 12249 11 + + CC cord-005453-4057qib7 12249 12 stem stem NN cord-005453-4057qib7 12249 13 cell cell NN cord-005453-4057qib7 12249 14 infusion infusion NN cord-005453-4057qib7 12249 15 , , , cord-005453-4057qib7 12249 16 we -PRON- PRP cord-005453-4057qib7 12249 17 suggest suggest VBP cord-005453-4057qib7 12249 18 that that IN cord-005453-4057qib7 12249 19 this this DT cord-005453-4057qib7 12249 20 procedure procedure NN cord-005453-4057qib7 12249 21 should should MD cord-005453-4057qib7 12249 22 be be VB cord-005453-4057qib7 12249 23 taken take VBN cord-005453-4057qib7 12249 24 in in IN cord-005453-4057qib7 12249 25 consideration consideration NN cord-005453-4057qib7 12249 26 in in IN cord-005453-4057qib7 12249 27 children child NNS cord-005453-4057qib7 12249 28 with with IN cord-005453-4057qib7 12249 29 severe severe JJ cord-005453-4057qib7 12249 30 bone bone NN cord-005453-4057qib7 12249 31 marrow marrow NN cord-005453-4057qib7 12249 32 hypoplasia hypoplasia NN cord-005453-4057qib7 12249 33 and and CC cord-005453-4057qib7 12249 34 persistent persistent JJ cord-005453-4057qib7 12249 35 cytopenia cytopenia NNS cord-005453-4057qib7 12249 36 after after IN cord-005453-4057qib7 12249 37 HSCT HSCT NNP cord-005453-4057qib7 12249 38 . . . cord-005453-4057qib7 12250 1 Disclosure disclosure NN cord-005453-4057qib7 12250 2 Background background NN cord-005453-4057qib7 12250 3 : : : cord-005453-4057qib7 12251 1 As as IN cord-005453-4057qib7 12251 2 allogeneic allogeneic IN cord-005453-4057qib7 12251 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 12251 4 stem stem NN cord-005453-4057qib7 12251 5 cell cell NN cord-005453-4057qib7 12251 6 transplantation transplantation NN cord-005453-4057qib7 12251 7 ( ( -LRB- cord-005453-4057qib7 12251 8 HSCT HSCT NNP cord-005453-4057qib7 12251 9 ) ) -RRB- cord-005453-4057qib7 12251 10 is be VBZ cord-005453-4057qib7 12251 11 sometimes sometimes RB cord-005453-4057qib7 12251 12 performed perform VBN cord-005453-4057qib7 12251 13 despite despite IN cord-005453-4057qib7 12251 14 erythrocyte erythrocyte NN cord-005453-4057qib7 12251 15 's 's POS cord-005453-4057qib7 12251 16 antigens antigen NNS cord-005453-4057qib7 12251 17 incompatibility incompatibility NN cord-005453-4057qib7 12251 18 and and CC cord-005453-4057qib7 12251 19 mismatch mismatch NN cord-005453-4057qib7 12251 20 , , , cord-005453-4057qib7 12251 21 it -PRON- PRP cord-005453-4057qib7 12251 22 is be VBZ cord-005453-4057qib7 12251 23 essential essential JJ cord-005453-4057qib7 12251 24 to to TO cord-005453-4057qib7 12251 25 carefully carefully RB cord-005453-4057qib7 12251 26 track track VB cord-005453-4057qib7 12251 27 patients patient NNS cord-005453-4057qib7 12251 28 ' ' POS cord-005453-4057qib7 12251 29 genotypes genotype NNS cord-005453-4057qib7 12251 30 after after IN cord-005453-4057qib7 12251 31 it -PRON- PRP cord-005453-4057qib7 12251 32 . . . cord-005453-4057qib7 12252 1 Methods method NNS cord-005453-4057qib7 12252 2 : : : cord-005453-4057qib7 12252 3 For for IN cord-005453-4057qib7 12252 4 the the DT cord-005453-4057qib7 12252 5 study study NN cord-005453-4057qib7 12252 6 we -PRON- PRP cord-005453-4057qib7 12252 7 used use VBD cord-005453-4057qib7 12252 8 erythrocytes erythrocyte NNS cord-005453-4057qib7 12252 9 ( ( -LRB- cord-005453-4057qib7 12252 10 N=189 N=189 NNP cord-005453-4057qib7 12252 11 ) ) -RRB- cord-005453-4057qib7 12252 12 and and CC cord-005453-4057qib7 12252 13 DNA DNA NNP cord-005453-4057qib7 12252 14 ( ( -LRB- cord-005453-4057qib7 12252 15 N=20 N=20 NNP cord-005453-4057qib7 12252 16 ) ) -RRB- cord-005453-4057qib7 12252 17 from from IN cord-005453-4057qib7 12252 18 patients patient NNS cord-005453-4057qib7 12252 19 undergoing undergo VBG cord-005453-4057qib7 12252 20 ABO ABO NNP cord-005453-4057qib7 12252 21 - - : cord-005453-4057qib7 12252 22 or or CC cord-005453-4057qib7 12252 23 Rhesus Rhesus NNP cord-005453-4057qib7 12252 24 - - HYPH cord-005453-4057qib7 12252 25 mismatch mismatch NN cord-005453-4057qib7 12252 26 HSCT HSCT NNP cord-005453-4057qib7 12252 27 and and CC cord-005453-4057qib7 12252 28 their -PRON- PRP$ cord-005453-4057qib7 12252 29 donors donor NNS cord-005453-4057qib7 12252 30 . . . cord-005453-4057qib7 12253 1 We -PRON- PRP cord-005453-4057qib7 12253 2 used use VBD cord-005453-4057qib7 12253 3 posttransplant posttransplant NNP cord-005453-4057qib7 12253 4 no no DT cord-005453-4057qib7 12253 5 transfused transfuse VBN cord-005453-4057qib7 12253 6 patients patient NNS cord-005453-4057qib7 12253 7 on on IN cord-005453-4057qib7 12253 8 the the DT cord-005453-4057qib7 12253 9 periods period NNS cord-005453-4057qib7 12253 10 according accord VBG cord-005453-4057qib7 12253 11 transplant transplant NN cord-005453-4057qib7 12253 12 protocol protocol NN cord-005453-4057qib7 12253 13 by by IN cord-005453-4057qib7 12253 14 hemagglutination hemagglutination NN cord-005453-4057qib7 12253 15 methods method NNS cord-005453-4057qib7 12253 16 in in IN cord-005453-4057qib7 12253 17 plate plate NN cord-005453-4057qib7 12253 18 and and CC cord-005453-4057qib7 12253 19 tube tube NN cord-005453-4057qib7 12253 20 using use VBG cord-005453-4057qib7 12253 21 monoclonal monoclonal JJ cord-005453-4057qib7 12253 22 antibodies antibody NNS cord-005453-4057qib7 12253 23 to to IN cord-005453-4057qib7 12253 24 ABO ABO NNP cord-005453-4057qib7 12253 25 and and CC cord-005453-4057qib7 12253 26 Rhesus Rhesus NNP cord-005453-4057qib7 12253 27 antigens antigen NNS cord-005453-4057qib7 12253 28 ( ( -LRB- cord-005453-4057qib7 12253 29 Hematolog Hematolog NNP cord-005453-4057qib7 12253 30 , , , cord-005453-4057qib7 12253 31 Russia Russia NNP cord-005453-4057qib7 12253 32 ) ) -RRB- cord-005453-4057qib7 12253 33 . . . cord-005453-4057qib7 12254 1 We -PRON- PRP cord-005453-4057qib7 12254 2 extracted extract VBD cord-005453-4057qib7 12254 3 DNA DNA NNP cord-005453-4057qib7 12254 4 with with IN cord-005453-4057qib7 12254 5 DNA dna NN cord-005453-4057qib7 12254 6 kit kit NN cord-005453-4057qib7 12254 7 ( ( -LRB- cord-005453-4057qib7 12254 8 BAG bag NN cord-005453-4057qib7 12254 9 , , , cord-005453-4057qib7 12254 10 Germany Germany NNP cord-005453-4057qib7 12254 11 ) ) -RRB- cord-005453-4057qib7 12254 12 and and CC cord-005453-4057qib7 12254 13 conducted conduct VBD cord-005453-4057qib7 12254 14 PCR PCR NNP cord-005453-4057qib7 12254 15 - - HYPH cord-005453-4057qib7 12254 16 SSP SSP NNP cord-005453-4057qib7 12254 17 with with IN cord-005453-4057qib7 12254 18 kits kit NNS cord-005453-4057qib7 12254 19 ABO ABO NNP cord-005453-4057qib7 12254 20 - - HYPH cord-005453-4057qib7 12254 21 Type Type NNP cord-005453-4057qib7 12254 22 , , , cord-005453-4057qib7 12254 23 RH RH NNP cord-005453-4057qib7 12254 24 - - HYPH cord-005453-4057qib7 12254 25 Type Type NNP cord-005453-4057qib7 12254 26 ( ( -LRB- cord-005453-4057qib7 12254 27 BAG bag NN cord-005453-4057qib7 12254 28 , , , cord-005453-4057qib7 12254 29 Germany Germany NNP cord-005453-4057qib7 12254 30 ) ) -RRB- cord-005453-4057qib7 12254 31 . . . cord-005453-4057qib7 12255 1 Chimerism chimerism NN cord-005453-4057qib7 12255 2 was be VBD cord-005453-4057qib7 12255 3 assessed assess VBN cord-005453-4057qib7 12255 4 by by IN cord-005453-4057qib7 12255 5 the the DT cord-005453-4057qib7 12255 6 STR STR NNP cord-005453-4057qib7 12255 7 - - HYPH cord-005453-4057qib7 12255 8 PCR PCR NNP cord-005453-4057qib7 12255 9 analysis analysis NN cord-005453-4057qib7 12255 10 with with IN cord-005453-4057qib7 12255 11 COrDIS COrDIS NNP cord-005453-4057qib7 12255 12 Plus Plus NNP cord-005453-4057qib7 12255 13 multiplex multiplex JJ cord-005453-4057qib7 12255 14 kit kit NN cord-005453-4057qib7 12255 15 for for IN cord-005453-4057qib7 12255 16 amplification amplification NN cord-005453-4057qib7 12255 17 of of IN cord-005453-4057qib7 12255 18 19 19 CD cord-005453-4057qib7 12255 19 polymorphic polymorphic JJ cord-005453-4057qib7 12255 20 STRmarkers strmarker NNS cord-005453-4057qib7 12255 21 and and CC cord-005453-4057qib7 12255 22 amelogenin amelogenin NNP cord-005453-4057qib7 12255 23 loci locus NNS cord-005453-4057qib7 12255 24 . . . cord-005453-4057qib7 12256 1 The the DT cord-005453-4057qib7 12256 2 fragment fragment NN cord-005453-4057qib7 12256 3 analysis analysis NN cord-005453-4057qib7 12256 4 was be VBD cord-005453-4057qib7 12256 5 performed perform VBN cord-005453-4057qib7 12256 6 on on IN cord-005453-4057qib7 12256 7 a a DT cord-005453-4057qib7 12256 8 3130 3130 CD cord-005453-4057qib7 12256 9 Genetic Genetic NNP cord-005453-4057qib7 12256 10 Analyzer Analyzer NNP cord-005453-4057qib7 12256 11 . . . cord-005453-4057qib7 12257 1 Informative informative JJ cord-005453-4057qib7 12257 2 loci locus NNS cord-005453-4057qib7 12257 3 were be VBD cord-005453-4057qib7 12257 4 chosen choose VBN cord-005453-4057qib7 12257 5 by by IN cord-005453-4057qib7 12257 6 comparison comparison NN cord-005453-4057qib7 12257 7 of of IN cord-005453-4057qib7 12257 8 pretransplant pretransplant JJ cord-005453-4057qib7 12257 9 patient patient NN cord-005453-4057qib7 12257 10 's 's POS cord-005453-4057qib7 12257 11 and and CC cord-005453-4057qib7 12257 12 donor donor NN cord-005453-4057qib7 12257 13 's 's POS cord-005453-4057qib7 12257 14 DNA dna NN cord-005453-4057qib7 12257 15 . . . cord-005453-4057qib7 12258 1 The the DT cord-005453-4057qib7 12258 2 percentage percentage NN cord-005453-4057qib7 12258 3 of of IN cord-005453-4057qib7 12258 4 donor donor NN cord-005453-4057qib7 12258 5 chimerism chimerism NN cord-005453-4057qib7 12258 6 was be VBD cord-005453-4057qib7 12258 7 calculated calculate VBN cord-005453-4057qib7 12258 8 using use VBG cord-005453-4057qib7 12258 9 standard standard JJ cord-005453-4057qib7 12258 10 formula formula NN cord-005453-4057qib7 12258 11 . . . cord-005453-4057qib7 12259 1 Precise precise JJ cord-005453-4057qib7 12259 2 RHCE RHCE NNP cord-005453-4057qib7 12259 3 and and CC cord-005453-4057qib7 12259 4 ABO ABO NNP cord-005453-4057qib7 12259 5 genotypes genotype NNS cord-005453-4057qib7 12259 6 were be VBD cord-005453-4057qib7 12259 7 determined determine VBN cord-005453-4057qib7 12259 8 by by IN cord-005453-4057qib7 12259 9 direct direct JJ cord-005453-4057qib7 12259 10 Sanger Sanger NNP cord-005453-4057qib7 12259 11 sequencing sequencing NN cord-005453-4057qib7 12259 12 . . . cord-005453-4057qib7 12260 1 We -PRON- PRP cord-005453-4057qib7 12260 2 revealed reveal VBD cord-005453-4057qib7 12260 3 3 3 CD cord-005453-4057qib7 12260 4 patients patient NNS cord-005453-4057qib7 12260 5 with with IN cord-005453-4057qib7 12260 6 unexpected unexpected JJ cord-005453-4057qib7 12260 7 erythrocyte erythrocyte NN cord-005453-4057qib7 12260 8 ABO ABO NNP cord-005453-4057qib7 12260 9 , , , cord-005453-4057qib7 12260 10 Rhesus Rhesus NNP cord-005453-4057qib7 12260 11 phenotypes phenotype NNS cord-005453-4057qib7 12260 12 and and CC cord-005453-4057qib7 12260 13 genotypes genotype NNS cord-005453-4057qib7 12260 14 after after IN cord-005453-4057qib7 12260 15 HSCT HSCT NNP cord-005453-4057qib7 12260 16 on on IN cord-005453-4057qib7 12260 17 +30 +30 NNP cord-005453-4057qib7 12260 18 ( ( -LRB- cord-005453-4057qib7 12260 19 2 2 CD cord-005453-4057qib7 12260 20 patients patient NNS cord-005453-4057qib7 12260 21 ) ) -RRB- cord-005453-4057qib7 12260 22 and and CC cord-005453-4057qib7 12260 23 +160 +160 NNP cord-005453-4057qib7 12260 24 days day NNS cord-005453-4057qib7 12260 25 ( ( -LRB- cord-005453-4057qib7 12260 26 all all DT cord-005453-4057qib7 12260 27 patients patient NNS cord-005453-4057qib7 12260 28 ) ) -RRB- cord-005453-4057qib7 12260 29 . . . cord-005453-4057qib7 12261 1 Chimerism chimerism NN cord-005453-4057qib7 12261 2 analyses analysis NNS cord-005453-4057qib7 12261 3 on on IN cord-005453-4057qib7 12261 4 STR STR NNP cord-005453-4057qib7 12261 5 showed show VBD cord-005453-4057qib7 12261 6 in in IN cord-005453-4057qib7 12262 1 A.E.Kh a.e.kh RB cord-005453-4057qib7 12262 2 . . . cord-005453-4057qib7 12263 1 and and CC cord-005453-4057qib7 12263 2 G.L.V. G.L.V. NNP cord-005453-4057qib7 12263 3 patients patient NNS cord-005453-4057qib7 12263 4 99 99 CD cord-005453-4057qib7 12263 5 % % NN cord-005453-4057qib7 12263 6 of of IN cord-005453-4057qib7 12263 7 donor donor NN cord-005453-4057qib7 12263 8 's 's POS cord-005453-4057qib7 12263 9 DNA dna NN cord-005453-4057qib7 12263 10 and and CC cord-005453-4057qib7 12263 11 less less JJR cord-005453-4057qib7 12263 12 than than IN cord-005453-4057qib7 12263 13 1 1 CD cord-005453-4057qib7 12263 14 % % NN cord-005453-4057qib7 12263 15 of of IN cord-005453-4057qib7 12263 16 recipient recipient NN cord-005453-4057qib7 12263 17 's 's POS cord-005453-4057qib7 12263 18 one one CD cord-005453-4057qib7 12263 19 . . . cord-005453-4057qib7 12264 1 B.N.A. B.N.A. NNP cord-005453-4057qib7 12264 2 patient patient NN cord-005453-4057qib7 12264 3 was be VBD cord-005453-4057qib7 12264 4 relapsed relapse VBN cord-005453-4057qib7 12264 5 and and CC cord-005453-4057qib7 12264 6 chimerism chimerism NN cord-005453-4057qib7 12264 7 analysis analysis NN cord-005453-4057qib7 12264 8 revealed reveal VBD cord-005453-4057qib7 12264 9 95 95 CD cord-005453-4057qib7 12264 10 % % NN cord-005453-4057qib7 12264 11 of of IN cord-005453-4057qib7 12264 12 recipient recipient NN cord-005453-4057qib7 12264 13 's 's POS cord-005453-4057qib7 12264 14 DNA dna NN cord-005453-4057qib7 12264 15 and and CC cord-005453-4057qib7 12264 16 5 5 CD cord-005453-4057qib7 12264 17 % % NN cord-005453-4057qib7 12264 18 of of IN cord-005453-4057qib7 12264 19 donor donor NN cord-005453-4057qib7 12264 20 's 's POS cord-005453-4057qib7 12264 21 one one CD cord-005453-4057qib7 12264 22 . . . cord-005453-4057qib7 12265 1 Using use VBG cord-005453-4057qib7 12265 2 serological serological JJ cord-005453-4057qib7 12265 3 methods method NNS cord-005453-4057qib7 12265 4 and and CC cord-005453-4057qib7 12265 5 PCR PCR NNP cord-005453-4057qib7 12265 6 - - HYPH cord-005453-4057qib7 12265 7 SSP SSP NNP cord-005453-4057qib7 12266 1 we -PRON- PRP cord-005453-4057qib7 12266 2 revealed reveal VBD cord-005453-4057qib7 12266 3 genotypes genotype NNS cord-005453-4057qib7 12266 4 ABO ABO NNP cord-005453-4057qib7 12266 5 * * NFP cord-005453-4057qib7 12266 6 A1B1 A1B1 NNP cord-005453-4057qib7 12266 7 ; ; : cord-005453-4057qib7 12266 8 RHD+ RHD+ NNP cord-005453-4057qib7 12266 9 ; ; : cord-005453-4057qib7 12266 10 RHCE RHCE NNP cord-005453-4057qib7 12266 11 * * NFP cord-005453-4057qib7 12266 12 CcEe CcEe NNP cord-005453-4057qib7 12266 13 in in IN cord-005453-4057qib7 12266 14 patient patient NN cord-005453-4057qib7 12266 15 A. a. NN cord-005453-4057qib7 12266 16 E.Kh E.Kh NNP cord-005453-4057qib7 12266 17 . . . cord-005453-4057qib7 12267 1 before before IN cord-005453-4057qib7 12267 2 HSCT HSCT NNP cord-005453-4057qib7 12267 3 , , , cord-005453-4057qib7 12267 4 ABO ABO NNP cord-005453-4057qib7 12267 5 * * NFP cord-005453-4057qib7 12267 6 A2O1 A2O1 NNP cord-005453-4057qib7 12267 7 ; ; : cord-005453-4057qib7 12267 8 RHD+ RHD+ NNP cord-005453-4057qib7 12267 9 ; ; : cord-005453-4057qib7 12267 10 RHCE RHCE NNP cord-005453-4057qib7 12268 1 * * NFP cord-005453-4057qib7 12268 2 Ccee Ccee NNP cord-005453-4057qib7 12268 3 in in IN cord-005453-4057qib7 12268 4 her -PRON- PRP$ cord-005453-4057qib7 12268 5 donor donor NN cord-005453-4057qib7 12268 6 , , , cord-005453-4057qib7 12268 7 and and CC cord-005453-4057qib7 12268 8 ABO ABO NNP cord-005453-4057qib7 12268 9 * * NFP cord-005453-4057qib7 12268 10 A1A2 A1A2 NNP cord-005453-4057qib7 12268 11 ; ; : cord-005453-4057qib7 12268 12 RHD+ RHD+ NNP cord-005453-4057qib7 12268 13 ; ; : cord-005453-4057qib7 12268 14 RHCE RHCE NNP cord-005453-4057qib7 12269 1 * * NFP cord-005453-4057qib7 12269 2 Ccee Ccee NNP cord-005453-4057qib7 12269 3 on on RP cord-005453-4057qib7 12269 4 +30d +30d NN cord-005453-4057qib7 12269 5 after after IN cord-005453-4057qib7 12269 6 HSCT HSCT NNP cord-005453-4057qib7 12269 7 . . . cord-005453-4057qib7 12270 1 Genotype Genotype NNP cord-005453-4057qib7 12270 2 A1A2 A1A2 NNP cord-005453-4057qib7 12270 3 was be VBD cord-005453-4057qib7 12270 4 no no DT cord-005453-4057qib7 12270 5 recipient recipient NN cord-005453-4057qib7 12270 6 's 's POS cord-005453-4057qib7 12270 7 neither neither DT cord-005453-4057qib7 12270 8 donor donor NN cord-005453-4057qib7 12270 9 's 's POS cord-005453-4057qib7 12270 10 origin origin NN cord-005453-4057qib7 12270 11 . . . cord-005453-4057qib7 12271 1 Direct direct JJ cord-005453-4057qib7 12271 2 sequencing sequencing NN cord-005453-4057qib7 12271 3 did do VBD cord-005453-4057qib7 12271 4 not not RB cord-005453-4057qib7 12271 5 prove prove VB cord-005453-4057qib7 12271 6 this this DT cord-005453-4057qib7 12271 7 genotype genotype NN cord-005453-4057qib7 12271 8 , , , cord-005453-4057qib7 12271 9 but but CC cord-005453-4057qib7 12271 10 revealed reveal VBD cord-005453-4057qib7 12271 11 donor donor NN cord-005453-4057qib7 12271 12 's 's POS cord-005453-4057qib7 12271 13 one one CD cord-005453-4057qib7 12271 14 . . . cord-005453-4057qib7 12272 1 On on IN cord-005453-4057qib7 12272 2 +160d +160d JJ cord-005453-4057qib7 12272 3 serological serological JJ cord-005453-4057qib7 12272 4 methods method NNS cord-005453-4057qib7 12272 5 and and CC cord-005453-4057qib7 12272 6 PCR PCR NNP cord-005453-4057qib7 12272 7 - - HYPH cord-005453-4057qib7 12272 8 SSP SSP NNP cord-005453-4057qib7 12272 9 also also RB cord-005453-4057qib7 12272 10 revealed reveal VBD cord-005453-4057qib7 12272 11 donor donor NN cord-005453-4057qib7 12272 12 's 's POS cord-005453-4057qib7 12272 13 genotype genotype NN cord-005453-4057qib7 12272 14 in in IN cord-005453-4057qib7 12272 15 this this DT cord-005453-4057qib7 12272 16 patient patient NN cord-005453-4057qib7 12272 17 . . . cord-005453-4057qib7 12273 1 Patient Patient NNP cord-005453-4057qib7 12273 2 B.N.A. B.N.A. NNP cord-005453-4057qib7 12273 3 had have VBD cord-005453-4057qib7 12273 4 genotypes genotype NNS cord-005453-4057qib7 12273 5 ABO ABO NNP cord-005453-4057qib7 12274 1 * * NFP cord-005453-4057qib7 12274 2 O01 O01 NNP cord-005453-4057qib7 12274 3 / / SYM cord-005453-4057qib7 12274 4 O01 O01 NNP cord-005453-4057qib7 12274 5 ; ; : cord-005453-4057qib7 12274 6 RHD+ RHD+ NNP cord-005453-4057qib7 12274 7 ; ; : cord-005453-4057qib7 12274 8 RHCE RHCE NNP cord-005453-4057qib7 12275 1 * * NFP cord-005453-4057qib7 12275 2 C C NNP cord-005453-4057qib7 12275 3 w w NNP cord-005453-4057qib7 12275 4 cEe cEe NNP cord-005453-4057qib7 12275 5 before before IN cord-005453-4057qib7 12275 6 HSCT HSCT NNP cord-005453-4057qib7 12275 7 , , , cord-005453-4057qib7 12275 8 her -PRON- PRP$ cord-005453-4057qib7 12275 9 donor donor NN cord-005453-4057qib7 12276 1 -ABO -ABO . cord-005453-4057qib7 12277 1 * * NFP cord-005453-4057qib7 12277 2 B1O1 B1O1 NNP cord-005453-4057qib7 12277 3 ; ; : cord-005453-4057qib7 12277 4 RHD RHD NNP cord-005453-4057qib7 12277 5 + + CC cord-005453-4057qib7 12277 6 ; ; : cord-005453-4057qib7 12277 7 RHCE RHCE NNP cord-005453-4057qib7 12277 8 * * NFP cord-005453-4057qib7 12277 9 Ccee Ccee NNP cord-005453-4057qib7 12277 10 . . . cord-005453-4057qib7 12278 1 On on IN cord-005453-4057qib7 12278 2 +160d +160d PDT cord-005453-4057qib7 12278 3 this this DT cord-005453-4057qib7 12278 4 patient patient NN cord-005453-4057qib7 12278 5 relapsed relapse VBD cord-005453-4057qib7 12278 6 , , , cord-005453-4057qib7 12278 7 but but CC cord-005453-4057qib7 12278 8 Rhesus Rhesus NNP cord-005453-4057qib7 12278 9 genotype genotype NN cord-005453-4057qib7 12278 10 has have VBZ cord-005453-4057qib7 12278 11 been be VBN cord-005453-4057qib7 12278 12 detected detect VBN cord-005453-4057qib7 12278 13 as as IN cord-005453-4057qib7 12278 14 RHD+ RHD+ NNP cord-005453-4057qib7 12278 15 ; ; : cord-005453-4057qib7 12278 16 RHCE RHCE NNP cord-005453-4057qib7 12279 1 * * NFP cord-005453-4057qib7 12279 2 C C NNP cord-005453-4057qib7 12279 3 wcee wcee NN cord-005453-4057qib7 12279 4 ( ( -LRB- cord-005453-4057qib7 12279 5 lack lack NN cord-005453-4057qib7 12279 6 E e NN cord-005453-4057qib7 12279 7 gene gene NN cord-005453-4057qib7 12279 8 ) ) -RRB- cord-005453-4057qib7 12279 9 . . . cord-005453-4057qib7 12280 1 Direct direct JJ cord-005453-4057qib7 12280 2 sequencing sequencing NN cord-005453-4057qib7 12280 3 revealed reveal VBD cord-005453-4057qib7 12280 4 gene gene NN cord-005453-4057qib7 12280 5 RHCE*Ee rhce*ee NN cord-005453-4057qib7 12280 6 . . . cord-005453-4057qib7 12281 1 ABO ABO NNP cord-005453-4057qib7 12281 2 genotype genotype NN cord-005453-4057qib7 12281 3 was be VBD cord-005453-4057qib7 12281 4 recipient recipient NN cord-005453-4057qib7 12281 5 's 's POS cord-005453-4057qib7 12281 6 origin origin NN cord-005453-4057qib7 12281 7 -O1O1 -o1o1 XX cord-005453-4057qib7 12281 8 . . . cord-005453-4057qib7 12282 1 In in IN cord-005453-4057qib7 12282 2 patient patient NN cord-005453-4057qib7 12282 3 G.L.V. G.L.V. NNP cord-005453-4057qib7 12282 4 using use VBG cord-005453-4057qib7 12282 5 serological serological JJ cord-005453-4057qib7 12282 6 and and CC cord-005453-4057qib7 12282 7 PCR PCR NNP cord-005453-4057qib7 12282 8 - - HYPH cord-005453-4057qib7 12282 9 SSP SSP NNP cord-005453-4057qib7 12282 10 methods method NNS cord-005453-4057qib7 12282 11 we -PRON- PRP cord-005453-4057qib7 12282 12 determined determine VBD cord-005453-4057qib7 12282 13 genotypes genotype NNS cord-005453-4057qib7 12282 14 ABO ABO NNP cord-005453-4057qib7 12282 15 * * NFP cord-005453-4057qib7 12282 16 O01 O01 NNP cord-005453-4057qib7 12282 17 / / SYM cord-005453-4057qib7 12282 18 O01 O01 NNP cord-005453-4057qib7 12282 19 ; ; : cord-005453-4057qib7 12282 20 RHD RHD NNP cord-005453-4057qib7 12282 21 + + CC cord-005453-4057qib7 12282 22 ; ; : cord-005453-4057qib7 12282 23 RHCE RHCE NNP cord-005453-4057qib7 12282 24 * * NFP cord-005453-4057qib7 12282 25 CCee CCee NNP cord-005453-4057qib7 12282 26 genotype genotype NN cord-005453-4057qib7 12282 27 before before IN cord-005453-4057qib7 12282 28 HSCT HSCT NNP cord-005453-4057qib7 12282 29 , , , cord-005453-4057qib7 12282 30 and and CC cord-005453-4057qib7 12282 31 ABO ABO NNP cord-005453-4057qib7 12282 32 * * NFP cord-005453-4057qib7 12282 33 A1/ A1/ NNP cord-005453-4057qib7 12282 34 O01 O01 NNP cord-005453-4057qib7 12282 35 ; ; : cord-005453-4057qib7 12282 36 RHD+ RHD+ NNP cord-005453-4057qib7 12282 37 ; ; : cord-005453-4057qib7 12282 38 RHCE RHCE NNP cord-005453-4057qib7 12282 39 * * NFP cord-005453-4057qib7 12282 40 CcEe CcEe NNP cord-005453-4057qib7 12282 41 genotype genotype NN cord-005453-4057qib7 12282 42 in in IN cord-005453-4057qib7 12282 43 her -PRON- PRP$ cord-005453-4057qib7 12282 44 HSC HSC NNP cord-005453-4057qib7 12282 45 donor donor NN cord-005453-4057qib7 12282 46 . . . cord-005453-4057qib7 12283 1 On on IN cord-005453-4057qib7 12283 2 +30d +30d NN cord-005453-4057qib7 12283 3 patient patient NN cord-005453-4057qib7 12283 4 had have VBD cord-005453-4057qib7 12283 5 unexpected unexpected JJ cord-005453-4057qib7 12283 6 genotype genotype NN cord-005453-4057qib7 12283 7 ABO ABO NNP cord-005453-4057qib7 12283 8 * * NFP cord-005453-4057qib7 12284 1 O01 O01 NNP cord-005453-4057qib7 12284 2 / / SYM cord-005453-4057qib7 12284 3 O01 O01 NNP cord-005453-4057qib7 12284 4 ( ( -LRB- cord-005453-4057qib7 12284 5 a a DT cord-005453-4057qib7 12284 6 lack lack NN cord-005453-4057qib7 12284 7 of of IN cord-005453-4057qib7 12284 8 A a DT cord-005453-4057qib7 12284 9 antigen antigen NN cord-005453-4057qib7 12284 10 ) ) -RRB- cord-005453-4057qib7 12284 11 ; ; : cord-005453-4057qib7 12284 12 RHCE RHCE NNP cord-005453-4057qib7 12284 13 * * NFP cord-005453-4057qib7 12285 1 Ccee Ccee NNP cord-005453-4057qib7 12285 2 ( ( -LRB- cord-005453-4057qib7 12285 3 a a DT cord-005453-4057qib7 12285 4 lack lack NN cord-005453-4057qib7 12285 5 of of IN cord-005453-4057qib7 12285 6 E e NN cord-005453-4057qib7 12285 7 antigen antigen NN cord-005453-4057qib7 12285 8 ) ) -RRB- cord-005453-4057qib7 12285 9 . . . cord-005453-4057qib7 12286 1 In in IN cord-005453-4057qib7 12286 2 order order NN cord-005453-4057qib7 12286 3 to to TO cord-005453-4057qib7 12286 4 explain explain VB cord-005453-4057qib7 12286 5 unexpected unexpected JJ cord-005453-4057qib7 12286 6 patient patient NN cord-005453-4057qib7 12286 7 's 's POS cord-005453-4057qib7 12286 8 genotypes genotype NNS cord-005453-4057qib7 12286 9 after after IN cord-005453-4057qib7 12286 10 HSCT HSCT NNP cord-005453-4057qib7 12286 11 we -PRON- PRP cord-005453-4057qib7 12286 12 sequenced sequence VBD cord-005453-4057qib7 12286 13 her -PRON- PRP$ cord-005453-4057qib7 12286 14 RHCE RHCE NNP cord-005453-4057qib7 12286 15 and and CC cord-005453-4057qib7 12286 16 ABO ABO NNP cord-005453-4057qib7 12286 17 genes gene NNS cord-005453-4057qib7 12286 18 and and CC cord-005453-4057qib7 12286 19 found find VBD cord-005453-4057qib7 12286 20 donor donor NN cord-005453-4057qib7 12286 21 's 's POS cord-005453-4057qib7 12286 22 genotype genotype NN cord-005453-4057qib7 12286 23 CcEe CcEe NNP cord-005453-4057qib7 12286 24 ; ; : cord-005453-4057qib7 12286 25 A1O1 A1O1 NNP cord-005453-4057qib7 12286 26 that that WDT cord-005453-4057qib7 12286 27 was be VBD cord-005453-4057qib7 12286 28 in in IN cord-005453-4057qib7 12286 29 agreement agreement NN cord-005453-4057qib7 12286 30 with with IN cord-005453-4057qib7 12286 31 results result NNS cord-005453-4057qib7 12286 32 of of IN cord-005453-4057qib7 12286 33 STR STR NNP cord-005453-4057qib7 12286 34 analysis analysis NN cord-005453-4057qib7 12286 35 . . . cord-005453-4057qib7 12287 1 To to TO cord-005453-4057qib7 12287 2 resolve resolve VB cord-005453-4057qib7 12287 3 discrepancies discrepancy NNS cord-005453-4057qib7 12287 4 between between IN cord-005453-4057qib7 12287 5 serological serological JJ cord-005453-4057qib7 12287 6 , , , cord-005453-4057qib7 12287 7 PCR PCR NNP cord-005453-4057qib7 12287 8 - - HYPH cord-005453-4057qib7 12287 9 SSP SSP NNP cord-005453-4057qib7 12287 10 and and CC cord-005453-4057qib7 12287 11 sequencing sequence VBG cord-005453-4057qib7 12287 12 analysis analysis NN cord-005453-4057qib7 12287 13 data datum NNS cord-005453-4057qib7 12287 14 we -PRON- PRP cord-005453-4057qib7 12287 15 sequenced sequence VBD cord-005453-4057qib7 12287 16 patient patient NN cord-005453-4057qib7 12287 17 's 's POS cord-005453-4057qib7 12287 18 RHCE RHCE NNP cord-005453-4057qib7 12287 19 cDNA cdna NN cord-005453-4057qib7 12287 20 and and CC cord-005453-4057qib7 12287 21 observed observe VBD cord-005453-4057qib7 12287 22 only only RB cord-005453-4057qib7 12287 23 Ce Ce NNP cord-005453-4057qib7 12287 24 allele allele NN cord-005453-4057qib7 12287 25 . . . cord-005453-4057qib7 12288 1 At at IN cord-005453-4057qib7 12288 2 present present JJ cord-005453-4057qib7 12288 3 time time NN cord-005453-4057qib7 12288 4 the the DT cord-005453-4057qib7 12288 5 molecular molecular JJ cord-005453-4057qib7 12288 6 basis basis NN cord-005453-4057qib7 12288 7 of of IN cord-005453-4057qib7 12288 8 selective selective JJ cord-005453-4057qib7 12288 9 inactivation inactivation NN cord-005453-4057qib7 12288 10 one one CD cord-005453-4057qib7 12288 11 of of IN cord-005453-4057qib7 12288 12 the the DT cord-005453-4057qib7 12288 13 two two CD cord-005453-4057qib7 12288 14 RHCE RHCE NNP cord-005453-4057qib7 12288 15 alleles allele NNS cord-005453-4057qib7 12288 16 is be VBZ cord-005453-4057qib7 12288 17 not not RB cord-005453-4057qib7 12288 18 clear clear JJ cord-005453-4057qib7 12288 19 . . . cord-005453-4057qib7 12289 1 On on IN cord-005453-4057qib7 12289 2 +160d +160d JJ cord-005453-4057qib7 12289 3 patient patient NN cord-005453-4057qib7 12289 4 had have VBD cord-005453-4057qib7 12289 5 donor donor NN cord-005453-4057qib7 12289 6 's 's POS cord-005453-4057qib7 12289 7 genotype genotype NN cord-005453-4057qib7 12289 8 . . . cord-005453-4057qib7 12290 1 Conclusions conclusion NNS cord-005453-4057qib7 12290 2 : : : cord-005453-4057qib7 12291 1 What what WDT cord-005453-4057qib7 12291 2 kind kind NN cord-005453-4057qib7 12291 3 of of IN cord-005453-4057qib7 12291 4 mechanisms mechanism NNS cord-005453-4057qib7 12291 5 led lead VBN cord-005453-4057qib7 12291 6 to to IN cord-005453-4057qib7 12291 7 discrepancies discrepancy NNS cord-005453-4057qib7 12291 8 between between IN cord-005453-4057qib7 12291 9 results result NNS cord-005453-4057qib7 12291 10 obtained obtain VBN cord-005453-4057qib7 12291 11 by by IN cord-005453-4057qib7 12291 12 different different JJ cord-005453-4057qib7 12291 13 laboratory laboratory NN cord-005453-4057qib7 12291 14 methods method NNS cord-005453-4057qib7 12291 15 are be VBP cord-005453-4057qib7 12291 16 still still RB cord-005453-4057qib7 12291 17 not not RB cord-005453-4057qib7 12291 18 clear clear JJ cord-005453-4057qib7 12291 19 . . . cord-005453-4057qib7 12292 1 An an DT cord-005453-4057qib7 12292 2 interesting interesting JJ cord-005453-4057qib7 12292 3 case case NN cord-005453-4057qib7 12292 4 of of IN cord-005453-4057qib7 12292 5 expression expression NN cord-005453-4057qib7 12292 6 of of IN cord-005453-4057qib7 12292 7 only only RB cord-005453-4057qib7 12292 8 one one CD cord-005453-4057qib7 12292 9 RHCE RHCE NNP cord-005453-4057qib7 12292 10 allele allele NN cord-005453-4057qib7 12292 11 in in IN cord-005453-4057qib7 12292 12 patient patient NN cord-005453-4057qib7 12292 13 G.L.V. G.L.V. NNP cord-005453-4057qib7 12292 14 allows allow VBZ cord-005453-4057qib7 12292 15 us -PRON- PRP cord-005453-4057qib7 12292 16 to to TO cord-005453-4057qib7 12292 17 suggest suggest VB cord-005453-4057qib7 12292 18 involvement involvement NN cord-005453-4057qib7 12292 19 of of IN cord-005453-4057qib7 12292 20 some some DT cord-005453-4057qib7 12292 21 epigenetic epigenetic JJ cord-005453-4057qib7 12292 22 mechanisms mechanism NNS cord-005453-4057qib7 12292 23 like like IN cord-005453-4057qib7 12292 24 DNA dna NN cord-005453-4057qib7 12292 25 methylation methylation NNS cord-005453-4057qib7 12292 26 or or CC cord-005453-4057qib7 12292 27 histone histone NN cord-005453-4057qib7 12292 28 modification modification NN cord-005453-4057qib7 12292 29 in in IN cord-005453-4057qib7 12292 30 this this DT cord-005453-4057qib7 12292 31 process process NN cord-005453-4057qib7 12292 32 . . . cord-005453-4057qib7 12293 1 Clinical clinical JJ cord-005453-4057qib7 12293 2 Background background NN cord-005453-4057qib7 12293 3 : : : cord-005453-4057qib7 12294 1 In in IN cord-005453-4057qib7 12294 2 relapsed relapsed JJ cord-005453-4057qib7 12294 3 patients patient NNS cord-005453-4057qib7 12294 4 with with IN cord-005453-4057qib7 12294 5 acute acute JJ cord-005453-4057qib7 12294 6 B b NN cord-005453-4057qib7 12294 7 -lymphoblastic -lymphoblastic CD cord-005453-4057qib7 12295 1 leukemia leukemia NN cord-005453-4057qib7 12295 2 ( ( -LRB- cord-005453-4057qib7 12295 3 ALL ALL NNP cord-005453-4057qib7 12295 4 - - HYPH cord-005453-4057qib7 12295 5 B b NN cord-005453-4057qib7 12295 6 ) ) -RRB- cord-005453-4057qib7 12295 7 who who WP cord-005453-4057qib7 12295 8 achieved achieve VBD cord-005453-4057qib7 12295 9 complete complete JJ cord-005453-4057qib7 12295 10 remission remission NN cord-005453-4057qib7 12295 11 ( ( -LRB- cord-005453-4057qib7 12295 12 CR CR NNP cord-005453-4057qib7 12295 13 ) ) -RRB- cord-005453-4057qib7 12295 14 after after IN cord-005453-4057qib7 12295 15 re re NN cord-005453-4057qib7 12295 16 - - NN cord-005453-4057qib7 12295 17 induction induction NN cord-005453-4057qib7 12295 18 therapy therapy NN cord-005453-4057qib7 12295 19 , , , cord-005453-4057qib7 12295 20 minimal minimal JJ cord-005453-4057qib7 12295 21 residual residual JJ cord-005453-4057qib7 12295 22 disease disease NN cord-005453-4057qib7 12295 23 ( ( -LRB- cord-005453-4057qib7 12295 24 MRD MRD NNP cord-005453-4057qib7 12295 25 ; ; : cord-005453-4057qib7 12295 26 ≥10 ≥10 NNP cord-005453-4057qib7 12295 27 -3 -3 NNP cord-005453-4057qib7 12295 28 ALL ALL NNP cord-005453-4057qib7 12295 29 - - HYPH cord-005453-4057qib7 12295 30 B b NN cord-005453-4057qib7 12295 31 cells cell NNS cord-005453-4057qib7 12295 32 / / SYM cord-005453-4057qib7 12295 33 ul ul NN cord-005453-4057qib7 12295 34 ) ) -RRB- cord-005453-4057qib7 12295 35 is be VBZ cord-005453-4057qib7 12295 36 often often RB cord-005453-4057qib7 12295 37 detected detect VBN cord-005453-4057qib7 12295 38 . . . cord-005453-4057qib7 12296 1 According accord VBG cord-005453-4057qib7 12296 2 to to IN cord-005453-4057qib7 12296 3 available available JJ cord-005453-4057qib7 12296 4 data datum NNS cord-005453-4057qib7 12296 5 , , , cord-005453-4057qib7 12296 6 such such JJ cord-005453-4057qib7 12296 7 condition condition NN cord-005453-4057qib7 12296 8 varies vary VBZ cord-005453-4057qib7 12296 9 from from IN cord-005453-4057qib7 12296 10 30 30 CD cord-005453-4057qib7 12296 11 % % NN cord-005453-4057qib7 12296 12 to to IN cord-005453-4057qib7 12296 13 even even RB cord-005453-4057qib7 12296 14 50 50 CD cord-005453-4057qib7 12296 15 % % NN cord-005453-4057qib7 12296 16 of of IN cord-005453-4057qib7 12296 17 cases case NNS cord-005453-4057qib7 12296 18 , , , cord-005453-4057qib7 12296 19 as as IN cord-005453-4057qib7 12296 20 assessed assess VBN cord-005453-4057qib7 12296 21 by by IN cord-005453-4057qib7 12296 22 PCR PCR NNP cord-005453-4057qib7 12296 23 or or CC cord-005453-4057qib7 12296 24 flow flow VB cord-005453-4057qib7 12296 25 cytometry cytometry NN cord-005453-4057qib7 12296 26 ( ( -LRB- cord-005453-4057qib7 12296 27 FC FC NNP cord-005453-4057qib7 12296 28 ) ) -RRB- cord-005453-4057qib7 12296 29 , , , cord-005453-4057qib7 12296 30 while while IN cord-005453-4057qib7 12296 31 the the DT cord-005453-4057qib7 12296 32 presence presence NN cord-005453-4057qib7 12296 33 of of IN cord-005453-4057qib7 12296 34 MRD MRD NNP cord-005453-4057qib7 12296 35 is be VBZ cord-005453-4057qib7 12296 36 the the DT cord-005453-4057qib7 12296 37 most most RBS cord-005453-4057qib7 12296 38 important important JJ cord-005453-4057qib7 12296 39 risk risk NN cord-005453-4057qib7 12296 40 factor factor NN cord-005453-4057qib7 12296 41 for for IN cord-005453-4057qib7 12296 42 ALL all DT cord-005453-4057qib7 12296 43 recurrence recurrence NN cord-005453-4057qib7 12296 44 . . . cord-005453-4057qib7 12297 1 In in IN cord-005453-4057qib7 12297 2 this this DT cord-005453-4057qib7 12297 3 abstract abstract NN cord-005453-4057qib7 12297 4 , , , cord-005453-4057qib7 12297 5 we -PRON- PRP cord-005453-4057qib7 12297 6 describe describe VBP cord-005453-4057qib7 12297 7 our -PRON- PRP$ cord-005453-4057qib7 12297 8 experience experience NN cord-005453-4057qib7 12297 9 with with IN cord-005453-4057qib7 12297 10 bridging bridge VBG cord-005453-4057qib7 12297 11 therapy therapy NN cord-005453-4057qib7 12297 12 using use VBG cord-005453-4057qib7 12297 13 blinatumomab blinatumomab JJ cord-005453-4057qib7 12297 14 infusion infusion NN cord-005453-4057qib7 12297 15 after after IN cord-005453-4057qib7 12297 16 re re NN cord-005453-4057qib7 12297 17 - - NN cord-005453-4057qib7 12297 18 induction induction JJ cord-005453-4057qib7 12297 19 regimens regimen NNS cord-005453-4057qib7 12297 20 and and CC cord-005453-4057qib7 12297 21 before before IN cord-005453-4057qib7 12297 22 the the DT cord-005453-4057qib7 12297 23 planned plan VBN cord-005453-4057qib7 12297 24 allogeneic allogeneic NN cord-005453-4057qib7 12297 25 stem stem NN cord-005453-4057qib7 12297 26 cell cell NN cord-005453-4057qib7 12297 27 transplantation transplantation NN cord-005453-4057qib7 12297 28 ( ( -LRB- cord-005453-4057qib7 12297 29 allo allo FW cord-005453-4057qib7 12297 30 - - HYPH cord-005453-4057qib7 12297 31 SCT SCT NNP cord-005453-4057qib7 12297 32 ) ) -RRB- cord-005453-4057qib7 12297 33 . . . cord-005453-4057qib7 12298 1 The the DT cord-005453-4057qib7 12298 2 procedure procedure NN cord-005453-4057qib7 12298 3 was be VBD cord-005453-4057qib7 12298 4 performed perform VBN cord-005453-4057qib7 12298 5 in in IN cord-005453-4057qib7 12298 6 three three CD cord-005453-4057qib7 12298 7 young young JJ cord-005453-4057qib7 12298 8 men man NNS cord-005453-4057qib7 12298 9 suffering suffer VBG cord-005453-4057qib7 12298 10 from from IN cord-005453-4057qib7 12298 11 relapsed relapse VBN cord-005453-4057qib7 12298 12 Ph Ph NNP cord-005453-4057qib7 12298 13 ( ( -LRB- cord-005453-4057qib7 12298 14 - - : cord-005453-4057qib7 12298 15 ) ) -RRB- cord-005453-4057qib7 12298 16 ALL ALL NNP cord-005453-4057qib7 12298 17 - - HYPH cord-005453-4057qib7 12298 18 B b NN cord-005453-4057qib7 12298 19 at at IN cord-005453-4057qib7 12298 20 the the DT cord-005453-4057qib7 12298 21 age age NN cord-005453-4057qib7 12298 22 of of IN cord-005453-4057qib7 12298 23 19 19 CD cord-005453-4057qib7 12298 24 , , , cord-005453-4057qib7 12298 25 22 22 CD cord-005453-4057qib7 12298 26 and and CC cord-005453-4057qib7 12298 27 34 34 CD cord-005453-4057qib7 12298 28 years year NNS cord-005453-4057qib7 12298 29 . . . cord-005453-4057qib7 12299 1 In in IN cord-005453-4057qib7 12299 2 the the DT cord-005453-4057qib7 12299 3 first first JJ cord-005453-4057qib7 12299 4 case case NN cord-005453-4057qib7 12299 5 ( ( -LRB- cord-005453-4057qib7 12299 6 19yo 19yo NNP cord-005453-4057qib7 12299 7 ) ) -RRB- cord-005453-4057qib7 12299 8 , , , cord-005453-4057qib7 12299 9 relapse relapse VB cord-005453-4057qib7 12299 10 with with IN cord-005453-4057qib7 12299 11 previous previous JJ cord-005453-4057qib7 12299 12 MRD MRD NNP cord-005453-4057qib7 12299 13 accounting account VBG cord-005453-4057qib7 12299 14 for for IN cord-005453-4057qib7 12299 15 2.7 2.7 CD cord-005453-4057qib7 12299 16 % % NN cord-005453-4057qib7 12299 17 occurred occur VBD cord-005453-4057qib7 12299 18 15 15 CD cord-005453-4057qib7 12299 19 months month NNS cord-005453-4057qib7 12299 20 after after IN cord-005453-4057qib7 12299 21 CR1 CR1 NNP cord-005453-4057qib7 12299 22 MRD MRD NNP cord-005453-4057qib7 12299 23 neg neg NNP cord-005453-4057qib7 12299 24 . . . cord-005453-4057qib7 12300 1 In in IN cord-005453-4057qib7 12300 2 the the DT cord-005453-4057qib7 12300 3 next next JJ cord-005453-4057qib7 12300 4 patient patient NN cord-005453-4057qib7 12300 5 ( ( -LRB- cord-005453-4057qib7 12300 6 22yo 22yo JJ cord-005453-4057qib7 12300 7 ) ) -RRB- cord-005453-4057qib7 12301 1 the the DT cord-005453-4057qib7 12301 2 second second JJ cord-005453-4057qib7 12301 3 relapse relapse NN cord-005453-4057qib7 12301 4 with with IN cord-005453-4057qib7 12301 5 central central JJ cord-005453-4057qib7 12301 6 nervous nervous JJ cord-005453-4057qib7 12301 7 system system NN cord-005453-4057qib7 12302 1 ( ( -LRB- cord-005453-4057qib7 12302 2 CNS CNS NNP cord-005453-4057qib7 12302 3 ) ) -RRB- cord-005453-4057qib7 12302 4 involvement involvement NN cord-005453-4057qib7 12302 5 occurred occur VBD cord-005453-4057qib7 12302 6 5 5 CD cord-005453-4057qib7 12302 7 months month NNS cord-005453-4057qib7 12302 8 after after IN cord-005453-4057qib7 12302 9 allo allo NN cord-005453-4057qib7 12302 10 - - HYPH cord-005453-4057qib7 12302 11 SCT SCT NNP cord-005453-4057qib7 12302 12 performed perform VBN cord-005453-4057qib7 12302 13 in in IN cord-005453-4057qib7 12302 14 CR2 CR2 NNP cord-005453-4057qib7 12302 15 ( ( -LRB- cord-005453-4057qib7 12302 16 26 26 CD cord-005453-4057qib7 12302 17 months month NNS cord-005453-4057qib7 12302 18 after after IN cord-005453-4057qib7 12302 19 CR1 CR1 NNP cord-005453-4057qib7 12302 20 , , , cord-005453-4057qib7 12302 21 MRD MRD NNP cord-005453-4057qib7 12302 22 neg neg NNP cord-005453-4057qib7 12302 23 ) ) -RRB- cord-005453-4057qib7 12302 24 , , , cord-005453-4057qib7 12302 25 while while IN cord-005453-4057qib7 12302 26 in in IN cord-005453-4057qib7 12302 27 the the DT cord-005453-4057qib7 12302 28 third third JJ cord-005453-4057qib7 12302 29 patient patient NN cord-005453-4057qib7 12302 30 ( ( -LRB- cord-005453-4057qib7 12302 31 34yo 34yo JJ cord-005453-4057qib7 12302 32 ) ) -RRB- cord-005453-4057qib7 12302 33 , , , cord-005453-4057qib7 12302 34 recurrence recurrence NN cord-005453-4057qib7 12302 35 with with IN cord-005453-4057qib7 12302 36 CNS CNS NNP cord-005453-4057qib7 12302 37 and and CC cord-005453-4057qib7 12302 38 testis testis NN cord-005453-4057qib7 12302 39 involvement involvement NN cord-005453-4057qib7 12302 40 occurred occur VBD cord-005453-4057qib7 12302 41 12 12 CD cord-005453-4057qib7 12302 42 years year NNS cord-005453-4057qib7 12302 43 after after IN cord-005453-4057qib7 12302 44 CR1 CR1 NNP cord-005453-4057qib7 12302 45 ( ( -LRB- cord-005453-4057qib7 12302 46 MRD MRD NNP cord-005453-4057qib7 12302 47 neg neg NNP cord-005453-4057qib7 12302 48 ) ) -RRB- cord-005453-4057qib7 12302 49 . . . cord-005453-4057qib7 12303 1 All all DT cord-005453-4057qib7 12303 2 patients patient NNS cord-005453-4057qib7 12303 3 underwent undergo VBD cord-005453-4057qib7 12303 4 chemotherapy chemotherapy NN cord-005453-4057qib7 12303 5 ( ( -LRB- cord-005453-4057qib7 12303 6 FLAM FLAM NNP cord-005453-4057qib7 12303 7 , , , cord-005453-4057qib7 12303 8 HyperCVAD HyperCVAD NNP cord-005453-4057qib7 12303 9 and and CC cord-005453-4057qib7 12303 10 DNR DNR NNP cord-005453-4057qib7 12303 11 / / SYM cord-005453-4057qib7 12303 12 VCR VCR NNP cord-005453-4057qib7 12303 13 / / SYM cord-005453-4057qib7 12303 14 PegAsp PegAsp NNP cord-005453-4057qib7 12303 15 / / SYM cord-005453-4057qib7 12303 16 Dexa Dexa NNP cord-005453-4057qib7 12303 17 regimens regimen NNS cord-005453-4057qib7 12303 18 respectively respectively RB cord-005453-4057qib7 12303 19 ) ) -RRB- cord-005453-4057qib7 12303 20 followed follow VBN cord-005453-4057qib7 12303 21 by by IN cord-005453-4057qib7 12303 22 one one CD cord-005453-4057qib7 12303 23 cycle cycle NN cord-005453-4057qib7 12303 24 of of IN cord-005453-4057qib7 12303 25 blinatumomab blinatumomab NN cord-005453-4057qib7 12303 26 ( ( -LRB- cord-005453-4057qib7 12303 27 at at IN cord-005453-4057qib7 12303 28 a a DT cord-005453-4057qib7 12303 29 dose dose NN cord-005453-4057qib7 12303 30 of of IN cord-005453-4057qib7 12303 31 9mcg 9mcg CD cord-005453-4057qib7 12303 32 / / SYM cord-005453-4057qib7 12303 33 d d NN cord-005453-4057qib7 12303 34 on on IN cord-005453-4057qib7 12303 35 days day NNS cord-005453-4057qib7 12303 36 1 1 CD cord-005453-4057qib7 12303 37 - - SYM cord-005453-4057qib7 12303 38 7 7 CD cord-005453-4057qib7 12303 39 , , , cord-005453-4057qib7 12303 40 followed follow VBN cord-005453-4057qib7 12303 41 by by IN cord-005453-4057qib7 12303 42 28mcg 28mcg CD cord-005453-4057qib7 12303 43 / / SYM cord-005453-4057qib7 12303 44 d d NN cord-005453-4057qib7 12303 45 on on IN cord-005453-4057qib7 12303 46 days day NNS cord-005453-4057qib7 12303 47 8 8 CD cord-005453-4057qib7 12303 48 - - SYM cord-005453-4057qib7 12303 49 28 28 CD cord-005453-4057qib7 12303 50 in in IN cord-005453-4057qib7 12303 51 a a DT cord-005453-4057qib7 12303 52 continuous continuous JJ cord-005453-4057qib7 12303 53 infusion infusion NN cord-005453-4057qib7 12303 54 ) ) -RRB- cord-005453-4057qib7 12303 55 and and CC cord-005453-4057qib7 12303 56 allo allo NN cord-005453-4057qib7 12303 57 - - HYPH cord-005453-4057qib7 12303 58 SCT SCT NNP cord-005453-4057qib7 12303 59 ( ( -LRB- cord-005453-4057qib7 12303 60 using use VBG cord-005453-4057qib7 12303 61 Eto Eto NNP cord-005453-4057qib7 12303 62 / / SYM cord-005453-4057qib7 12303 63 Cy Cy NNP cord-005453-4057qib7 12303 64 / / SYM cord-005453-4057qib7 12303 65 TBI TBI NNP cord-005453-4057qib7 12303 66 / / SYM cord-005453-4057qib7 12303 67 ATG/ atg/ JJ cord-005453-4057qib7 12303 68 conditioning conditioning NN cord-005453-4057qib7 12303 69 regimen regimen NN cord-005453-4057qib7 12303 70 for for IN cord-005453-4057qib7 12303 71 Ist Ist NNP cord-005453-4057qib7 12303 72 and and CC cord-005453-4057qib7 12303 73 IIIrd IIIrd NNP cord-005453-4057qib7 12303 74 patient patient NN cord-005453-4057qib7 12303 75 and and CC cord-005453-4057qib7 12303 76 BuCy2 BuCy2 NNS cord-005453-4057qib7 12303 77 for for IN cord-005453-4057qib7 12303 78 IInd IInd NNP cord-005453-4057qib7 12303 79 patient patient JJ cord-005453-4057qib7 12303 80 ; ; : cord-005453-4057qib7 12303 81 using use VBG cord-005453-4057qib7 12303 82 matched match VBN cord-005453-4057qib7 12303 83 unrelated unrelated JJ cord-005453-4057qib7 12303 84 donor donor NN cord-005453-4057qib7 12303 85 ( ( -LRB- cord-005453-4057qib7 12303 86 MUD mud NN cord-005453-4057qib7 12303 87 , , , cord-005453-4057qib7 12303 88 Ist Ist NNP cord-005453-4057qib7 12303 89 and and CC cord-005453-4057qib7 12303 90 IIIrd IIIrd NNP cord-005453-4057qib7 12303 91 patient patient JJ cord-005453-4057qib7 12303 92 ) ) -RRB- cord-005453-4057qib7 12303 93 or or CC cord-005453-4057qib7 12303 94 matched match VBN cord-005453-4057qib7 12303 95 related related JJ cord-005453-4057qib7 12303 96 donor donor NN cord-005453-4057qib7 12303 97 ( ( -LRB- cord-005453-4057qib7 12303 98 IInd IInd NNP cord-005453-4057qib7 12303 99 patient patient NN cord-005453-4057qib7 12303 100 ) ) -RRB- cord-005453-4057qib7 12303 101 ) ) -RRB- cord-005453-4057qib7 12303 102 . . . cord-005453-4057qib7 12304 1 MRD MRD NNP cord-005453-4057qib7 12304 2 status status NN cord-005453-4057qib7 12304 3 was be VBD cord-005453-4057qib7 12304 4 assessed assess VBN cord-005453-4057qib7 12304 5 after after IN cord-005453-4057qib7 12304 6 each each DT cord-005453-4057qib7 12304 7 cycle cycle NN cord-005453-4057qib7 12304 8 of of IN cord-005453-4057qib7 12304 9 blinatumomab blinatumomab NN cord-005453-4057qib7 12304 10 by by IN cord-005453-4057qib7 12304 11 FC FC NNP cord-005453-4057qib7 12304 12 . . . cord-005453-4057qib7 12305 1 Results result NNS cord-005453-4057qib7 12305 2 : : : cord-005453-4057qib7 12306 1 All all DT cord-005453-4057qib7 12306 2 patients patient NNS cord-005453-4057qib7 12306 3 achieved achieve VBD cord-005453-4057qib7 12306 4 CR CR NNP cord-005453-4057qib7 12306 5 MRD MRD NNP cord-005453-4057qib7 12306 6 pos pos NN cord-005453-4057qib7 12306 7 after after IN cord-005453-4057qib7 12306 8 reinduction reinduction NN cord-005453-4057qib7 12306 9 therapy therapy NN cord-005453-4057qib7 12306 10 followed follow VBN cord-005453-4057qib7 12306 11 by by IN cord-005453-4057qib7 12306 12 clearance clearance NN cord-005453-4057qib7 12306 13 of of IN cord-005453-4057qib7 12306 14 MRD MRD NNP cord-005453-4057qib7 12306 15 after after IN cord-005453-4057qib7 12306 16 blinatumomab blinatumomab NNP cord-005453-4057qib7 12306 17 course course NN cord-005453-4057qib7 12306 18 ( ( -LRB- cord-005453-4057qib7 12306 19 Tab Tab NNP cord-005453-4057qib7 12306 20 . . . cord-005453-4057qib7 12306 21 1 1 CD cord-005453-4057qib7 12306 22 ) ) -RRB- cord-005453-4057qib7 12306 23 . . . cord-005453-4057qib7 12307 1 The the DT cord-005453-4057qib7 12307 2 second second JJ cord-005453-4057qib7 12307 3 patient patient NN cord-005453-4057qib7 12307 4 , , , cord-005453-4057qib7 12307 5 due due IN cord-005453-4057qib7 12307 6 to to IN cord-005453-4057qib7 12307 7 positive positive JJ cord-005453-4057qib7 12307 8 MRD MRD NNP cord-005453-4057qib7 12307 9 6 6 CD cord-005453-4057qib7 12307 10 months month NNS cord-005453-4057qib7 12307 11 after after IN cord-005453-4057qib7 12307 12 allo allo NN cord-005453-4057qib7 12307 13 - - HYPH cord-005453-4057qib7 12307 14 SCT SCT NNP cord-005453-4057qib7 12307 15 received receive VBD cord-005453-4057qib7 12307 16 4 4 CD cord-005453-4057qib7 12307 17 donor donor NN cord-005453-4057qib7 12307 18 lymphocyte lymphocyte NN cord-005453-4057qib7 12307 19 infusions infusion NNS cord-005453-4057qib7 12307 20 additionally additionally RB cord-005453-4057qib7 12307 21 . . . cord-005453-4057qib7 12308 1 During during IN cord-005453-4057qib7 12308 2 the the DT cord-005453-4057qib7 12308 3 administration administration NN cord-005453-4057qib7 12308 4 of of IN cord-005453-4057qib7 12308 5 blinatumomab blinatumomab NNP cord-005453-4057qib7 12308 6 , , , cord-005453-4057qib7 12308 7 no no DT cord-005453-4057qib7 12308 8 adverse adverse JJ cord-005453-4057qib7 12308 9 events event NNS cord-005453-4057qib7 12308 10 ( ( -LRB- cord-005453-4057qib7 12308 11 AEs AEs NNP cord-005453-4057qib7 12308 12 ) ) -RRB- cord-005453-4057qib7 12308 13 were be VBD cord-005453-4057qib7 12308 14 observed observe VBN cord-005453-4057qib7 12308 15 in in IN cord-005453-4057qib7 12308 16 grade grade NN cord-005453-4057qib7 12308 17 3 3 CD cord-005453-4057qib7 12308 18 or or CC cord-005453-4057qib7 12308 19 4 4 CD cord-005453-4057qib7 12308 20 . . . cord-005453-4057qib7 12309 1 One one CD cord-005453-4057qib7 12309 2 patient patient NN cord-005453-4057qib7 12309 3 developed develop VBD cord-005453-4057qib7 12309 4 cytokine cytokine NN cord-005453-4057qib7 12309 5 release release NN cord-005453-4057qib7 12309 6 syndrome syndrome NN cord-005453-4057qib7 12309 7 in in IN cord-005453-4057qib7 12309 8 grade grade NN cord-005453-4057qib7 12309 9 1 1 CD cord-005453-4057qib7 12309 10 . . . cord-005453-4057qib7 12310 1 The the DT cord-005453-4057qib7 12310 2 progression progression NN cord-005453-4057qib7 12310 3 free free JJ cord-005453-4057qib7 12310 4 survival survival NN cord-005453-4057qib7 12310 5 , , , cord-005453-4057qib7 12310 6 time time NN cord-005453-4057qib7 12310 7 to to IN cord-005453-4057qib7 12310 8 positive positive JJ cord-005453-4057qib7 12310 9 MRD MRD NNP cord-005453-4057qib7 12310 10 and and CC cord-005453-4057qib7 12310 11 follow follow VB cord-005453-4057qib7 12310 12 up up RP cord-005453-4057qib7 12310 13 are be VBP cord-005453-4057qib7 12310 14 presented present VBN cord-005453-4057qib7 12310 15 in in IN cord-005453-4057qib7 12310 16 Tab Tab NNP cord-005453-4057qib7 12310 17 1 1 CD cord-005453-4057qib7 12310 18 . . . cord-005453-4057qib7 12311 1 Conclusions conclusion NNS cord-005453-4057qib7 12311 2 : : : cord-005453-4057qib7 12312 1 The the DT cord-005453-4057qib7 12312 2 use use NN cord-005453-4057qib7 12312 3 of of IN cord-005453-4057qib7 12312 4 blinatumomab blinatumomab NN cord-005453-4057qib7 12312 5 as as IN cord-005453-4057qib7 12312 6 a a DT cord-005453-4057qib7 12312 7 bridging bridge VBG cord-005453-4057qib7 12312 8 therapy therapy NN cord-005453-4057qib7 12312 9 between between IN cord-005453-4057qib7 12312 10 re re NN cord-005453-4057qib7 12312 11 - - NN cord-005453-4057qib7 12312 12 induction induction JJ cord-005453-4057qib7 12312 13 regimens regimen NNS cord-005453-4057qib7 12312 14 and and CC cord-005453-4057qib7 12312 15 allo allo NN cord-005453-4057qib7 12312 16 - - HYPH cord-005453-4057qib7 12312 17 SCT sct NN cord-005453-4057qib7 12312 18 in in IN cord-005453-4057qib7 12312 19 patients patient NNS cord-005453-4057qib7 12312 20 with with IN cord-005453-4057qib7 12312 21 ALL all DT cord-005453-4057qib7 12312 22 - - HYPH cord-005453-4057qib7 12312 23 B B NNP cord-005453-4057qib7 12312 24 and and CC cord-005453-4057qib7 12312 25 MRD MRD NNP cord-005453-4057qib7 12312 26 pos pos NNP cord-005453-4057qib7 12312 27 appears appear VBZ cord-005453-4057qib7 12312 28 to to TO cord-005453-4057qib7 12312 29 be be VB cord-005453-4057qib7 12312 30 safe safe JJ cord-005453-4057qib7 12312 31 and and CC cord-005453-4057qib7 12312 32 leads lead VBZ cord-005453-4057qib7 12312 33 to to IN cord-005453-4057qib7 12312 34 the the DT cord-005453-4057qib7 12312 35 clearance clearance NN cord-005453-4057qib7 12312 36 of of IN cord-005453-4057qib7 12312 37 MRD MRD NNP cord-005453-4057qib7 12312 38 which which WDT cord-005453-4057qib7 12312 39 may may MD cord-005453-4057qib7 12312 40 be be VB cord-005453-4057qib7 12312 41 crucial crucial JJ cord-005453-4057qib7 12312 42 in in IN cord-005453-4057qib7 12312 43 OS OS NNP cord-005453-4057qib7 12312 44 and and CC cord-005453-4057qib7 12312 45 PFS PFS NNP cord-005453-4057qib7 12312 46 prolongation prolongation NN cord-005453-4057qib7 12312 47 after after IN cord-005453-4057qib7 12312 48 following follow VBG cord-005453-4057qib7 12312 49 allo allo NN cord-005453-4057qib7 12312 50 - - HYPH cord-005453-4057qib7 12312 51 SCT sct NN cord-005453-4057qib7 12312 52 . . . cord-005453-4057qib7 12313 1 Future future JJ cord-005453-4057qib7 12313 2 studies study NNS cord-005453-4057qib7 12313 3 on on IN cord-005453-4057qib7 12313 4 larger large JJR cord-005453-4057qib7 12313 5 groups group NNS cord-005453-4057qib7 12313 6 of of IN cord-005453-4057qib7 12313 7 patients patient NNS cord-005453-4057qib7 12313 8 are be VBP cord-005453-4057qib7 12313 9 necessary necessary JJ cord-005453-4057qib7 12313 10 to to TO cord-005453-4057qib7 12313 11 confirm confirm VB cord-005453-4057qib7 12313 12 this this DT cord-005453-4057qib7 12313 13 thesis thesis NN cord-005453-4057qib7 12313 14 . . . cord-005453-4057qib7 12314 1 Background background NN cord-005453-4057qib7 12314 2 : : : cord-005453-4057qib7 12315 1 Haploidentical Haploidentical NNP cord-005453-4057qib7 12315 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 12315 3 stem stem NN cord-005453-4057qib7 12315 4 cell cell NN cord-005453-4057qib7 12315 5 transplantation transplantation NN cord-005453-4057qib7 12315 6 ( ( -LRB- cord-005453-4057qib7 12315 7 HSCT HSCT NNP cord-005453-4057qib7 12315 8 ) ) -RRB- cord-005453-4057qib7 12315 9 is be VBZ cord-005453-4057qib7 12315 10 considered consider VBN cord-005453-4057qib7 12315 11 an an DT cord-005453-4057qib7 12315 12 alternative alternative JJ cord-005453-4057qib7 12315 13 treatment treatment NN cord-005453-4057qib7 12315 14 for for IN cord-005453-4057qib7 12315 15 hematologic hematologic JJ cord-005453-4057qib7 12315 16 malignancies malignancy NNS cord-005453-4057qib7 12315 17 in in IN cord-005453-4057qib7 12315 18 patients patient NNS cord-005453-4057qib7 12315 19 who who WP cord-005453-4057qib7 12315 20 do do VBP cord-005453-4057qib7 12315 21 not not RB cord-005453-4057qib7 12315 22 have have VB cord-005453-4057qib7 12315 23 an an DT cord-005453-4057qib7 12315 24 HLA HLA NNP cord-005453-4057qib7 12315 25 - - HYPH cord-005453-4057qib7 12315 26 identical identical JJ cord-005453-4057qib7 12315 27 sibling sibling NN cord-005453-4057qib7 12315 28 donor donor NN cord-005453-4057qib7 12315 29 [ [ -LRB- cord-005453-4057qib7 12315 30 1 1 CD cord-005453-4057qib7 12315 31 ] ] -RRB- cord-005453-4057qib7 12315 32 . . . cord-005453-4057qib7 12316 1 Since since IN cord-005453-4057qib7 12316 2 infections infection NNS cord-005453-4057qib7 12316 3 and and CC cord-005453-4057qib7 12316 4 disease disease NN cord-005453-4057qib7 12316 5 relapse relapse NN cord-005453-4057qib7 12316 6 resulting result VBG cord-005453-4057qib7 12316 7 from from IN cord-005453-4057qib7 12316 8 delayed delay VBN cord-005453-4057qib7 12316 9 immune immune JJ cord-005453-4057qib7 12316 10 reconstitution reconstitution NN cord-005453-4057qib7 12316 11 ( ( -LRB- cord-005453-4057qib7 12316 12 IR IR NNP cord-005453-4057qib7 12316 13 ) ) -RRB- cord-005453-4057qib7 12316 14 are be VBP cord-005453-4057qib7 12316 15 the the DT cord-005453-4057qib7 12316 16 most most RBS cord-005453-4057qib7 12316 17 common common JJ cord-005453-4057qib7 12316 18 causes cause NNS cord-005453-4057qib7 12316 19 of of IN cord-005453-4057qib7 12316 20 mortality mortality NN cord-005453-4057qib7 12316 21 among among IN cord-005453-4057qib7 12316 22 patients patient NNS cord-005453-4057qib7 12316 23 undergoing undergo VBG cord-005453-4057qib7 12316 24 haploidentical haploidentical JJ cord-005453-4057qib7 12316 25 - - HYPH cord-005453-4057qib7 12316 26 HSCT HSCT NNP cord-005453-4057qib7 12316 27 [ [ -LRB- cord-005453-4057qib7 12316 28 2 2 CD cord-005453-4057qib7 12316 29 ] ] -RRB- cord-005453-4057qib7 12316 30 , , , cord-005453-4057qib7 12316 31 timely timely RB cord-005453-4057qib7 12316 32 IR IR NNP cord-005453-4057qib7 12316 33 is be VBZ cord-005453-4057qib7 12316 34 essential essential JJ cord-005453-4057qib7 12316 35 in in IN cord-005453-4057qib7 12316 36 the the DT cord-005453-4057qib7 12316 37 recovery recovery NN cord-005453-4057qib7 12316 38 and and CC cord-005453-4057qib7 12316 39 survival survival NN cord-005453-4057qib7 12316 40 of of IN cord-005453-4057qib7 12316 41 these these DT cord-005453-4057qib7 12316 42 patients patient NNS cord-005453-4057qib7 12316 43 . . . cord-005453-4057qib7 12317 1 The the DT cord-005453-4057qib7 12317 2 aim aim NN cord-005453-4057qib7 12317 3 of of IN cord-005453-4057qib7 12317 4 this this DT cord-005453-4057qib7 12317 5 study study NN cord-005453-4057qib7 12317 6 is be VBZ cord-005453-4057qib7 12317 7 to to TO cord-005453-4057qib7 12317 8 describe describe VB cord-005453-4057qib7 12317 9 the the DT cord-005453-4057qib7 12317 10 evolution evolution NN cord-005453-4057qib7 12317 11 of of IN cord-005453-4057qib7 12317 12 IR IR NNP cord-005453-4057qib7 12317 13 after after IN cord-005453-4057qib7 12317 14 haploidentical haploidentical JJ cord-005453-4057qib7 12317 15 - - HYPH cord-005453-4057qib7 12317 16 HSCT HSCT NNP cord-005453-4057qib7 12317 17 and and CC cord-005453-4057qib7 12317 18 to to TO cord-005453-4057qib7 12317 19 estimate estimate VB cord-005453-4057qib7 12317 20 survival survival NN cord-005453-4057qib7 12317 21 rates rate NNS cord-005453-4057qib7 12317 22 in in IN cord-005453-4057qib7 12317 23 patients patient NNS cord-005453-4057qib7 12317 24 with with IN cord-005453-4057qib7 12317 25 delayed delay VBN cord-005453-4057qib7 12317 26 vs. vs. IN cord-005453-4057qib7 12317 27 adequate adequate JJ cord-005453-4057qib7 12317 28 reconstitution reconstitution NN cord-005453-4057qib7 12317 29 in in IN cord-005453-4057qib7 12317 30 a a DT cord-005453-4057qib7 12317 31 single single JJ cord-005453-4057qib7 12317 32 center center NN cord-005453-4057qib7 12317 33 in in IN cord-005453-4057qib7 12317 34 Colombia Colombia NNP cord-005453-4057qib7 12317 35 , , , cord-005453-4057qib7 12317 36 South South NNP cord-005453-4057qib7 12317 37 America America NNP cord-005453-4057qib7 12317 38 . . . cord-005453-4057qib7 12318 1 Methods method NNS cord-005453-4057qib7 12318 2 : : : cord-005453-4057qib7 12319 1 A a DT cord-005453-4057qib7 12319 2 retrospective retrospective JJ cord-005453-4057qib7 12319 3 cohort cohort NN cord-005453-4057qib7 12319 4 study study NN cord-005453-4057qib7 12319 5 was be VBD cord-005453-4057qib7 12319 6 conducted conduct VBN cord-005453-4057qib7 12319 7 on on IN cord-005453-4057qib7 12319 8 26 26 CD cord-005453-4057qib7 12319 9 consecutive consecutive JJ cord-005453-4057qib7 12319 10 adult adult NN cord-005453-4057qib7 12319 11 haploidentical haploidentical JJ cord-005453-4057qib7 12319 12 - - HYPH cord-005453-4057qib7 12319 13 HSCT HSCT NNP cord-005453-4057qib7 12319 14 recipients recipient NNS cord-005453-4057qib7 12319 15 at at IN cord-005453-4057qib7 12319 16 a a DT cord-005453-4057qib7 12319 17 tertiary tertiary JJ cord-005453-4057qib7 12319 18 referral referral NN cord-005453-4057qib7 12319 19 center center NN cord-005453-4057qib7 12319 20 . . . cord-005453-4057qib7 12320 1 CD4+cells CD4+cells NNP cord-005453-4057qib7 12320 2 , , , cord-005453-4057qib7 12320 3 CD8+cells CD8+cells NNPS cord-005453-4057qib7 12320 4 , , , cord-005453-4057qib7 12320 5 CD3+cells CD3+cells NNP cord-005453-4057qib7 12320 6 , , , cord-005453-4057qib7 12320 7 and and CC cord-005453-4057qib7 12320 8 immunoglobulins immunoglobulin NNS cord-005453-4057qib7 12320 9 levels level NNS cord-005453-4057qib7 12320 10 were be VBD cord-005453-4057qib7 12320 11 monitored monitor VBN cord-005453-4057qib7 12320 12 before before IN cord-005453-4057qib7 12320 13 HSCT HSCT NNP cord-005453-4057qib7 12320 14 , , , cord-005453-4057qib7 12320 15 at at IN cord-005453-4057qib7 12320 16 first first JJ cord-005453-4057qib7 12320 17 month month NN cord-005453-4057qib7 12320 18 , , , cord-005453-4057qib7 12320 19 and and CC cord-005453-4057qib7 12320 20 then then RB cord-005453-4057qib7 12320 21 every every DT cord-005453-4057qib7 12320 22 three three CD cord-005453-4057qib7 12320 23 months month NNS cord-005453-4057qib7 12320 24 for for IN cord-005453-4057qib7 12320 25 the the DT cord-005453-4057qib7 12320 26 first first JJ cord-005453-4057qib7 12320 27 two two CD cord-005453-4057qib7 12320 28 years year NNS cord-005453-4057qib7 12320 29 post post NN cord-005453-4057qib7 12320 30 - - NN cord-005453-4057qib7 12320 31 transplantation transplantation NN cord-005453-4057qib7 12320 32 . . . cord-005453-4057qib7 12321 1 Descriptive descriptive JJ cord-005453-4057qib7 12321 2 statistics statistic NNS cord-005453-4057qib7 12321 3 were be VBD cord-005453-4057qib7 12321 4 used use VBN cord-005453-4057qib7 12321 5 to to TO cord-005453-4057qib7 12321 6 analyze analyze VB cord-005453-4057qib7 12321 7 patient patient NN cord-005453-4057qib7 12321 8 's 's POS cord-005453-4057qib7 12321 9 clinical clinical JJ cord-005453-4057qib7 12321 10 characteristics characteristic NNS cord-005453-4057qib7 12321 11 . . . cord-005453-4057qib7 12322 1 The the DT cord-005453-4057qib7 12322 2 Kaplan Kaplan NNP cord-005453-4057qib7 12322 3 - - HYPH cord-005453-4057qib7 12322 4 Meier Meier NNP cord-005453-4057qib7 12322 5 method method NN cord-005453-4057qib7 12322 6 was be VBD cord-005453-4057qib7 12322 7 used use VBN cord-005453-4057qib7 12322 8 to to TO cord-005453-4057qib7 12322 9 assess assess VB cord-005453-4057qib7 12322 10 overall overall JJ cord-005453-4057qib7 12322 11 survival survival NN cord-005453-4057qib7 12322 12 ( ( -LRB- cord-005453-4057qib7 12322 13 OS OS NNP cord-005453-4057qib7 12322 14 ) ) -RRB- cord-005453-4057qib7 12322 15 and and CC cord-005453-4057qib7 12322 16 relapse relapse NN cord-005453-4057qib7 12322 17 - - HYPH cord-005453-4057qib7 12322 18 free free JJ cord-005453-4057qib7 12322 19 survival survival NN cord-005453-4057qib7 12322 20 ( ( -LRB- cord-005453-4057qib7 12322 21 RFS RFS NNP cord-005453-4057qib7 12322 22 ) ) -RRB- cord-005453-4057qib7 12322 23 rates rate NNS cord-005453-4057qib7 12322 24 . . . cord-005453-4057qib7 12323 1 Results result NNS cord-005453-4057qib7 12323 2 : : : cord-005453-4057qib7 12324 1 Twenty twenty CD cord-005453-4057qib7 12324 2 - - HYPH cord-005453-4057qib7 12324 3 six six CD cord-005453-4057qib7 12324 4 patients patient NNS cord-005453-4057qib7 12324 5 were be VBD cord-005453-4057qib7 12324 6 included include VBN cord-005453-4057qib7 12324 7 ( ( -LRB- cord-005453-4057qib7 12324 8 50 50 CD cord-005453-4057qib7 12324 9 % % NN cord-005453-4057qib7 12324 10 were be VBD cord-005453-4057qib7 12324 11 male male JJ cord-005453-4057qib7 12324 12 ) ) -RRB- cord-005453-4057qib7 12324 13 , , , cord-005453-4057qib7 12324 14 with with IN cord-005453-4057qib7 12324 15 a a DT cord-005453-4057qib7 12324 16 median median JJ cord-005453-4057qib7 12324 17 age age NN cord-005453-4057qib7 12324 18 of of IN cord-005453-4057qib7 12324 19 25.5 25.5 CD cord-005453-4057qib7 12324 20 years year NNS cord-005453-4057qib7 12325 1 ( ( -LRB- cord-005453-4057qib7 12325 2 range range NNP cord-005453-4057qib7 12325 3 16 16 CD cord-005453-4057qib7 12325 4 - - SYM cord-005453-4057qib7 12325 5 59 59 CD cord-005453-4057qib7 12325 6 ) ) -RRB- cord-005453-4057qib7 12325 7 . . . cord-005453-4057qib7 12326 1 The the DT cord-005453-4057qib7 12326 2 most most RBS cord-005453-4057qib7 12326 3 common common JJ cord-005453-4057qib7 12326 4 indication indication NN cord-005453-4057qib7 12326 5 for for IN cord-005453-4057qib7 12326 6 haploidentical haploidentical JJ cord-005453-4057qib7 12326 7 HSCT HSCT NNP cord-005453-4057qib7 12326 8 was be VBD cord-005453-4057qib7 12326 9 acute acute JJ cord-005453-4057qib7 12326 10 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 12326 11 leukemia leukemia NN cord-005453-4057qib7 12326 12 ( ( -LRB- cord-005453-4057qib7 12326 13 n=21 n=21 NNP cord-005453-4057qib7 12326 14 , , , cord-005453-4057qib7 12326 15 80.8 80.8 CD cord-005453-4057qib7 12326 16 % % NN cord-005453-4057qib7 12326 17 ) ) -RRB- cord-005453-4057qib7 12326 18 , , , cord-005453-4057qib7 12326 19 followed follow VBN cord-005453-4057qib7 12326 20 by by IN cord-005453-4057qib7 12326 21 non non JJ cord-005453-4057qib7 12326 22 - - JJ cord-005453-4057qib7 12326 23 Hodgkin Hodgkin NNP cord-005453-4057qib7 12326 24 lymphoma lymphoma NN cord-005453-4057qib7 12326 25 ( ( -LRB- cord-005453-4057qib7 12326 26 n=3 n=3 NN cord-005453-4057qib7 12326 27 , , , cord-005453-4057qib7 12326 28 11 11 CD cord-005453-4057qib7 12326 29 .5 .5 CD cord-005453-4057qib7 12326 30 % % NN cord-005453-4057qib7 12326 31 ) ) -RRB- cord-005453-4057qib7 12326 32 and and CC cord-005453-4057qib7 12326 33 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 12326 34 syndrome syndrome NN cord-005453-4057qib7 12326 35 ( ( -LRB- cord-005453-4057qib7 12326 36 n=2 n=2 NNS cord-005453-4057qib7 12326 37 , , , cord-005453-4057qib7 12326 38 7.7 7.7 CD cord-005453-4057qib7 12326 39 % % NN cord-005453-4057qib7 12326 40 ) ) -RRB- cord-005453-4057qib7 12326 41 . . . cord-005453-4057qib7 12327 1 All all DT cord-005453-4057qib7 12327 2 patients patient NNS cord-005453-4057qib7 12327 3 received receive VBD cord-005453-4057qib7 12327 4 GvHD GvHD NNP cord-005453-4057qib7 12327 5 prophylaxis prophylaxis NN cord-005453-4057qib7 12327 6 therapy therapy NN cord-005453-4057qib7 12327 7 with with IN cord-005453-4057qib7 12327 8 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12327 9 , , , cord-005453-4057qib7 12327 10 tacrolimus tacrolimus NNP cord-005453-4057qib7 12327 11 , , , cord-005453-4057qib7 12327 12 and and CC cord-005453-4057qib7 12327 13 mycophenolate mycophenolate NNP cord-005453-4057qib7 12327 14 mofetil mofetil NNP cord-005453-4057qib7 12327 15 . . . cord-005453-4057qib7 12328 1 Fifteen fifteen CD cord-005453-4057qib7 12328 2 patients patient NNS cord-005453-4057qib7 12328 3 ( ( -LRB- cord-005453-4057qib7 12328 4 57.7 57.7 CD cord-005453-4057qib7 12328 5 % % NN cord-005453-4057qib7 12328 6 ) ) -RRB- cord-005453-4057qib7 12328 7 presented present VBD cord-005453-4057qib7 12328 8 cytomegalovirus cytomegalovirus JJ cord-005453-4057qib7 12328 9 reactivation reactivation NN cord-005453-4057qib7 12328 10 ( ( -LRB- cord-005453-4057qib7 12328 11 25/26 25/26 CD cord-005453-4057qib7 12328 12 at at IN cord-005453-4057qib7 12328 13 risk risk NN cord-005453-4057qib7 12328 14 ) ) -RRB- cord-005453-4057qib7 12328 15 , , , cord-005453-4057qib7 12328 16 5 5 CD cord-005453-4057qib7 12328 17 patients patient NNS cord-005453-4057qib7 12328 18 ( ( -LRB- cord-005453-4057qib7 12328 19 19.2 19.2 CD cord-005453-4057qib7 12328 20 % % NN cord-005453-4057qib7 12328 21 ) ) -RRB- cord-005453-4057qib7 12328 22 Epstein Epstein NNP cord-005453-4057qib7 12328 23 - - HYPH cord-005453-4057qib7 12328 24 Barr Barr NNP cord-005453-4057qib7 12328 25 virus virus NN cord-005453-4057qib7 12328 26 reactivation reactivation NN cord-005453-4057qib7 12328 27 , , , cord-005453-4057qib7 12328 28 and and CC cord-005453-4057qib7 12328 29 4 4 CD cord-005453-4057qib7 12328 30 patients patient NNS cord-005453-4057qib7 12328 31 ( ( -LRB- cord-005453-4057qib7 12328 32 15.4 15.4 CD cord-005453-4057qib7 12328 33 % % NN cord-005453-4057qib7 12328 34 ) ) -RRB- cord-005453-4057qib7 12328 35 developed develop VBD cord-005453-4057qib7 12328 36 adenovirus adenovirus NN cord-005453-4057qib7 12328 37 infection infection NN cord-005453-4057qib7 12328 38 . . . cord-005453-4057qib7 12329 1 Median median JJ cord-005453-4057qib7 12329 2 time time NN cord-005453-4057qib7 12329 3 to to IN cord-005453-4057qib7 12329 4 neutrophil neutrophil NN cord-005453-4057qib7 12329 5 engraftment engraftment NN cord-005453-4057qib7 12330 1 ( ( -LRB- cord-005453-4057qib7 12330 2 neutrophils>0.5×10 neutrophils>0.5×10 NNP cord-005453-4057qib7 12330 3 9 9 CD cord-005453-4057qib7 12330 4 /L /L . cord-005453-4057qib7 12330 5 ) ) -RRB- cord-005453-4057qib7 12330 6 was be VBD cord-005453-4057qib7 12330 7 15 15 CD cord-005453-4057qib7 12330 8 days day NNS cord-005453-4057qib7 12330 9 ( ( -LRB- cord-005453-4057qib7 12330 10 range12 range12 NNP cord-005453-4057qib7 12330 11 - - HYPH cord-005453-4057qib7 12330 12 29 29 CD cord-005453-4057qib7 12330 13 ) ) -RRB- cord-005453-4057qib7 12330 14 for for IN cord-005453-4057qib7 12330 15 the the DT cord-005453-4057qib7 12330 16 23 23 CD cord-005453-4057qib7 12330 17 patients patient NNS cord-005453-4057qib7 12330 18 recipients recipient NNS cord-005453-4057qib7 12330 19 of of IN cord-005453-4057qib7 12330 20 peripheral peripheral JJ cord-005453-4057qib7 12330 21 blood blood NN cord-005453-4057qib7 12330 22 progenitor progenitor NN cord-005453-4057qib7 12330 23 cells cell NNS cord-005453-4057qib7 12330 24 ( ( -LRB- cord-005453-4057qib7 12330 25 PBPCs pbpc NNS cord-005453-4057qib7 12330 26 ) ) -RRB- cord-005453-4057qib7 12330 27 and and CC cord-005453-4057qib7 12330 28 21 21 CD cord-005453-4057qib7 12330 29 days day NNS cord-005453-4057qib7 12330 30 ( ( -LRB- cord-005453-4057qib7 12330 31 range20 range20 NNP cord-005453-4057qib7 12330 32 - - HYPH cord-005453-4057qib7 12330 33 27 27 CD cord-005453-4057qib7 12330 34 ) ) -RRB- cord-005453-4057qib7 12330 35 for for IN cord-005453-4057qib7 12330 36 the the DT cord-005453-4057qib7 12330 37 three three CD cord-005453-4057qib7 12330 38 remaining remain VBG cord-005453-4057qib7 12330 39 bone bone NN cord-005453-4057qib7 12330 40 marrow marrow NN cord-005453-4057qib7 12330 41 recipients recipient NNS cord-005453-4057qib7 12330 42 . . . cord-005453-4057qib7 12331 1 Platelet platelet NN cord-005453-4057qib7 12331 2 engraftment engraftment NN cord-005453-4057qib7 12331 3 , , , cord-005453-4057qib7 12331 4 defined define VBN cord-005453-4057qib7 12331 5 as as IN cord-005453-4057qib7 12331 6 > > XX cord-005453-4057qib7 12331 7 20,000 20,000 CD cord-005453-4057qib7 12331 8 platelets/ platelets/ SYM cord-005453-4057qib7 12331 9 mm mm NN cord-005453-4057qib7 12331 10 3 3 CD cord-005453-4057qib7 12331 11 Background Background NNP cord-005453-4057qib7 12331 12 : : : cord-005453-4057qib7 12331 13 Daratumumab Daratumumab NNP cord-005453-4057qib7 12331 14 is be VBZ cord-005453-4057qib7 12331 15 a a DT cord-005453-4057qib7 12331 16 human human JJ cord-005453-4057qib7 12331 17 monoclonal monoclonal JJ cord-005453-4057qib7 12331 18 antibody antibody NN cord-005453-4057qib7 12331 19 directed direct VBN cord-005453-4057qib7 12331 20 against against IN cord-005453-4057qib7 12331 21 the the DT cord-005453-4057qib7 12331 22 glycoprotein glycoprotein NN cord-005453-4057qib7 12331 23 CD38 CD38 NNP cord-005453-4057qib7 12331 24 that that WDT cord-005453-4057qib7 12331 25 is be VBZ cord-005453-4057qib7 12331 26 overexpressed overexpresse VBN cord-005453-4057qib7 12331 27 on on IN cord-005453-4057qib7 12331 28 the the DT cord-005453-4057qib7 12331 29 surface surface NN cord-005453-4057qib7 12331 30 of of IN cord-005453-4057qib7 12331 31 plasma plasma NN cord-005453-4057qib7 12331 32 cells cell NNS cord-005453-4057qib7 12331 33 in in IN cord-005453-4057qib7 12331 34 multiple multiple JJ cord-005453-4057qib7 12331 35 myeloma myeloma NN cord-005453-4057qib7 12331 36 patients patient NNS cord-005453-4057qib7 12331 37 . . . cord-005453-4057qib7 12332 1 It -PRON- PRP cord-005453-4057qib7 12332 2 is be VBZ cord-005453-4057qib7 12332 3 approved approve VBN cord-005453-4057qib7 12332 4 as as IN cord-005453-4057qib7 12332 5 second second JJ cord-005453-4057qib7 12332 6 line line NN cord-005453-4057qib7 12332 7 therapy therapy NN cord-005453-4057qib7 12332 8 either either CC cord-005453-4057qib7 12332 9 as as IN cord-005453-4057qib7 12332 10 single single JJ cord-005453-4057qib7 12332 11 agent agent NN cord-005453-4057qib7 12332 12 therapy therapy NN cord-005453-4057qib7 12332 13 or or CC cord-005453-4057qib7 12332 14 in in IN cord-005453-4057qib7 12332 15 combination combination NN cord-005453-4057qib7 12332 16 with with IN cord-005453-4057qib7 12332 17 lenalidomide lenalidomide NN cord-005453-4057qib7 12332 18 or or CC cord-005453-4057qib7 12332 19 bortezomib bortezomib NNP cord-005453-4057qib7 12332 20 for for IN cord-005453-4057qib7 12332 21 the the DT cord-005453-4057qib7 12332 22 treatment treatment NN cord-005453-4057qib7 12332 23 of of IN cord-005453-4057qib7 12332 24 patients patient NNS cord-005453-4057qib7 12332 25 with with IN cord-005453-4057qib7 12332 26 relapsed relapse VBN cord-005453-4057qib7 12332 27 / / SYM cord-005453-4057qib7 12332 28 refractory refractory JJ cord-005453-4057qib7 12332 29 multiple multiple JJ cord-005453-4057qib7 12332 30 myeloma myeloma NN cord-005453-4057qib7 12332 31 . . . cord-005453-4057qib7 12333 1 Despite despite IN cord-005453-4057qib7 12333 2 the the DT cord-005453-4057qib7 12333 3 curative curative JJ cord-005453-4057qib7 12333 4 potential potential NN cord-005453-4057qib7 12333 5 of of IN cord-005453-4057qib7 12333 6 an an DT cord-005453-4057qib7 12333 7 allo allo NN cord-005453-4057qib7 12333 8 - - HYPH cord-005453-4057qib7 12333 9 SCT SCT NNP cord-005453-4057qib7 12333 10 , , , cord-005453-4057qib7 12333 11 the the DT cord-005453-4057qib7 12333 12 high high JJ cord-005453-4057qib7 12333 13 relapse relapse NN cord-005453-4057qib7 12333 14 rate rate NN cord-005453-4057qib7 12333 15 remains remain VBZ cord-005453-4057qib7 12333 16 a a DT cord-005453-4057qib7 12333 17 clinical clinical JJ cord-005453-4057qib7 12333 18 problem problem NN cord-005453-4057qib7 12333 19 . . . cord-005453-4057qib7 12334 1 Data datum NNS cord-005453-4057qib7 12334 2 addressing address VBG cord-005453-4057qib7 12334 3 the the DT cord-005453-4057qib7 12334 4 choice choice NN cord-005453-4057qib7 12334 5 of of IN cord-005453-4057qib7 12334 6 an an DT cord-005453-4057qib7 12334 7 optimal optimal JJ cord-005453-4057qib7 12334 8 salvage salvage NN cord-005453-4057qib7 12334 9 therapy therapy NN cord-005453-4057qib7 12334 10 regime regime NN cord-005453-4057qib7 12334 11 for for IN cord-005453-4057qib7 12334 12 these these DT cord-005453-4057qib7 12334 13 heavily heavily RB cord-005453-4057qib7 12334 14 pre pre JJ cord-005453-4057qib7 12334 15 - - JJ cord-005453-4057qib7 12334 16 treated treat VBN cord-005453-4057qib7 12334 17 patients patient NNS cord-005453-4057qib7 12334 18 is be VBZ cord-005453-4057qib7 12334 19 missing miss VBG cord-005453-4057qib7 12334 20 . . . cord-005453-4057qib7 12335 1 Methods method NNS cord-005453-4057qib7 12335 2 : : : cord-005453-4057qib7 12336 1 From from IN cord-005453-4057qib7 12336 2 April April NNP cord-005453-4057qib7 12336 3 2016 2016 CD cord-005453-4057qib7 12336 4 till till IN cord-005453-4057qib7 12336 5 November November NNP cord-005453-4057qib7 12336 6 2018 2018 CD cord-005453-4057qib7 12336 7 a a DT cord-005453-4057qib7 12336 8 total total NN cord-005453-4057qib7 12336 9 of of IN cord-005453-4057qib7 12336 10 22 22 CD cord-005453-4057qib7 12336 11 patients patient NNS cord-005453-4057qib7 12336 12 ( ( -LRB- cord-005453-4057qib7 12336 13 male male NNP cord-005453-4057qib7 12336 14 , , , cord-005453-4057qib7 12336 15 n=10 n=10 NNP cord-005453-4057qib7 12336 16 ) ) -RRB- cord-005453-4057qib7 12336 17 with with IN cord-005453-4057qib7 12336 18 the the DT cord-005453-4057qib7 12336 19 median median JJ cord-005453-4057qib7 12336 20 age age NN cord-005453-4057qib7 12336 21 of of IN cord-005453-4057qib7 12336 22 64 64 CD cord-005453-4057qib7 12336 23 years year NNS cord-005453-4057qib7 12336 24 ( ( -LRB- cord-005453-4057qib7 12336 25 40 40 CD cord-005453-4057qib7 12336 26 - - SYM cord-005453-4057qib7 12336 27 72 72 CD cord-005453-4057qib7 12336 28 ) ) -RRB- cord-005453-4057qib7 12336 29 received receive VBD cord-005453-4057qib7 12336 30 daratumumab daratumumab NNP cord-005453-4057qib7 12336 31 as as IN cord-005453-4057qib7 12336 32 a a DT cord-005453-4057qib7 12336 33 salvage salvage NN cord-005453-4057qib7 12336 34 therapy therapy NN cord-005453-4057qib7 12336 35 for for IN cord-005453-4057qib7 12336 36 relapse relapse NN cord-005453-4057qib7 12336 37 of of IN cord-005453-4057qib7 12336 38 multiple multiple JJ cord-005453-4057qib7 12336 39 myeloma myeloma NN cord-005453-4057qib7 12336 40 after after IN cord-005453-4057qib7 12336 41 allo allo NN cord-005453-4057qib7 12336 42 - - HYPH cord-005453-4057qib7 12336 43 SCT SCT NNP cord-005453-4057qib7 12336 44 at at IN cord-005453-4057qib7 12336 45 the the DT cord-005453-4057qib7 12336 46 University University NNP cord-005453-4057qib7 12336 47 of of IN cord-005453-4057qib7 12336 48 Hamburg Hamburg NNP cord-005453-4057qib7 12336 49 . . . cord-005453-4057qib7 12337 1 Prior prior RB cord-005453-4057qib7 12337 2 to to IN cord-005453-4057qib7 12337 3 allo allo NN cord-005453-4057qib7 12337 4 - - HYPH cord-005453-4057qib7 12337 5 SCT SCT NNP cord-005453-4057qib7 12337 6 all all DT cord-005453-4057qib7 12337 7 but but CC cord-005453-4057qib7 12337 8 one one CD cord-005453-4057qib7 12337 9 patient patient NN cord-005453-4057qib7 12337 10 had have VBD cord-005453-4057qib7 12337 11 received receive VBN cord-005453-4057qib7 12337 12 an an DT cord-005453-4057qib7 12337 13 autograft autograft NN cord-005453-4057qib7 12337 14 , , , cord-005453-4057qib7 12337 15 9 9 CD cord-005453-4057qib7 12337 16 patients patient NNS cord-005453-4057qib7 12337 17 even even RB cord-005453-4057qib7 12337 18 ≥2 ≥2 NNP cord-005453-4057qib7 12337 19 autografts autografts NNP cord-005453-4057qib7 12337 20 and and CC cord-005453-4057qib7 12337 21 4 4 CD cord-005453-4057qib7 12337 22 patients patient NNS cord-005453-4057qib7 12337 23 also also RB cord-005453-4057qib7 12337 24 a a DT cord-005453-4057qib7 12337 25 1 1 CD cord-005453-4057qib7 12337 26 . . . cord-005453-4057qib7 12337 27 allograft allograft NN cord-005453-4057qib7 12337 28 . . . cord-005453-4057qib7 12338 1 The the DT cord-005453-4057qib7 12338 2 median median JJ cord-005453-4057qib7 12338 3 number number NN cord-005453-4057qib7 12338 4 of of IN cord-005453-4057qib7 12338 5 salvage salvage NN cord-005453-4057qib7 12338 6 lines line NNS cord-005453-4057qib7 12338 7 post post JJ cord-005453-4057qib7 12338 8 - - NN cord-005453-4057qib7 12338 9 transplant transplant JJ cord-005453-4057qib7 12338 10 and and CC cord-005453-4057qib7 12338 11 prior prior RB cord-005453-4057qib7 12338 12 to to IN cord-005453-4057qib7 12338 13 first first JJ cord-005453-4057qib7 12338 14 daratumumab daratumumab JJ cord-005453-4057qib7 12338 15 infusion infusion NN cord-005453-4057qib7 12338 16 was be VBD cord-005453-4057qib7 12338 17 2 2 CD cord-005453-4057qib7 12338 18 ( ( -LRB- cord-005453-4057qib7 12338 19 0 0 CD cord-005453-4057qib7 12338 20 - - SYM cord-005453-4057qib7 12338 21 4 4 CD cord-005453-4057qib7 12338 22 ) ) -RRB- cord-005453-4057qib7 12338 23 . . . cord-005453-4057qib7 12339 1 These these DT cord-005453-4057qib7 12339 2 salvage salvage NN cord-005453-4057qib7 12339 3 regimens regimen NNS cord-005453-4057qib7 12339 4 included include VBD cord-005453-4057qib7 12339 5 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 12339 6 , , , cord-005453-4057qib7 12339 7 etoposide etoposide RB cord-005453-4057qib7 12339 8 , , , cord-005453-4057qib7 12339 9 bortezomib bortezomib NNP cord-005453-4057qib7 12339 10 , , , cord-005453-4057qib7 12339 11 lenalidomide lenalidomide NNP cord-005453-4057qib7 12339 12 , , , cord-005453-4057qib7 12339 13 pomalidomide pomalidomide NNP cord-005453-4057qib7 12339 14 and and CC cord-005453-4057qib7 12339 15 carfilzomib carfilzomib NNP cord-005453-4057qib7 12339 16 . . . cord-005453-4057qib7 12340 1 Daratumumab Daratumumab NNP cord-005453-4057qib7 12340 2 was be VBD cord-005453-4057qib7 12340 3 started start VBN cord-005453-4057qib7 12340 4 at at IN cord-005453-4057qib7 12340 5 a a DT cord-005453-4057qib7 12340 6 median median NN cord-005453-4057qib7 12340 7 of of IN cord-005453-4057qib7 12340 8 19 19 CD cord-005453-4057qib7 12340 9 months month NNS cord-005453-4057qib7 12340 10 ( ( -LRB- cord-005453-4057qib7 12340 11 0 0 CD cord-005453-4057qib7 12340 12 - - SYM cord-005453-4057qib7 12340 13 43 43 CD cord-005453-4057qib7 12340 14 ) ) -RRB- cord-005453-4057qib7 12340 15 after after IN cord-005453-4057qib7 12340 16 relapse/ relapse/ NN cord-005453-4057qib7 12340 17 progress progress NN cord-005453-4057qib7 12340 18 and and CC cord-005453-4057qib7 12340 19 initiated initiate VBD cord-005453-4057qib7 12340 20 as as IN cord-005453-4057qib7 12340 21 single single JJ cord-005453-4057qib7 12340 22 agent agent NN cord-005453-4057qib7 12340 23 therapy therapy NN cord-005453-4057qib7 12340 24 in in IN cord-005453-4057qib7 12340 25 all all DT cord-005453-4057qib7 12340 26 patients patient NNS cord-005453-4057qib7 12340 27 . . . cord-005453-4057qib7 12341 1 Concomitantly concomitantly RB cord-005453-4057qib7 12341 2 , , , cord-005453-4057qib7 12341 3 14 14 CD cord-005453-4057qib7 12341 4 patients patient NNS cord-005453-4057qib7 12341 5 received receive VBN cord-005453-4057qib7 12341 6 either either CC cord-005453-4057qib7 12341 7 an an DT cord-005453-4057qib7 12341 8 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 12341 9 drug drug NN cord-005453-4057qib7 12341 10 ( ( -LRB- cord-005453-4057qib7 12341 11 lenalidomid lenalidomid NNP cord-005453-4057qib7 12341 12 , , , cord-005453-4057qib7 12341 13 n=10 n=10 NNP cord-005453-4057qib7 12341 14 ; ; : cord-005453-4057qib7 12341 15 pomalidomid pomalidomid NNP cord-005453-4057qib7 12341 16 , , , cord-005453-4057qib7 12341 17 n=1 n=1 CD cord-005453-4057qib7 12341 18 ) ) -RRB- cord-005453-4057qib7 12341 19 or or CC cord-005453-4057qib7 12341 20 a a DT cord-005453-4057qib7 12341 21 proteasome proteasome VBN cord-005453-4057qib7 12341 22 inhibitor inhibitor NN cord-005453-4057qib7 12341 23 ( ( -LRB- cord-005453-4057qib7 12341 24 bortezomib bortezomib NNP cord-005453-4057qib7 12341 25 , , , cord-005453-4057qib7 12341 26 n=3 n=3 NN cord-005453-4057qib7 12341 27 ) ) -RRB- cord-005453-4057qib7 12341 28 during during IN cord-005453-4057qib7 12341 29 a a DT cord-005453-4057qib7 12341 30 later later JJ cord-005453-4057qib7 12341 31 course course NN cord-005453-4057qib7 12341 32 of of IN cord-005453-4057qib7 12341 33 daratumumab daratumumab VBN cord-005453-4057qib7 12341 34 infusions infusion NNS cord-005453-4057qib7 12341 35 . . . cord-005453-4057qib7 12342 1 Combination combination NN cord-005453-4057qib7 12342 2 therapy therapy NN cord-005453-4057qib7 12342 3 was be VBD cord-005453-4057qib7 12342 4 initiated initiate VBN cord-005453-4057qib7 12342 5 when when WRB cord-005453-4057qib7 12342 6 a a DT cord-005453-4057qib7 12342 7 slow slow JJ cord-005453-4057qib7 12342 8 rise rise NN cord-005453-4057qib7 12342 9 of of IN cord-005453-4057qib7 12342 10 paraprotein paraprotein NNP cord-005453-4057qib7 12342 11 and/or and/or CC cord-005453-4057qib7 12342 12 free free JJ cord-005453-4057qib7 12342 13 light light JJ cord-005453-4057qib7 12342 14 chains chain NNS cord-005453-4057qib7 12342 15 or or CC cord-005453-4057qib7 12342 16 no no DT cord-005453-4057qib7 12342 17 response response NN cord-005453-4057qib7 12342 18 to to IN cord-005453-4057qib7 12342 19 monotherapy monotherapy NN cord-005453-4057qib7 12342 20 was be VBD cord-005453-4057qib7 12342 21 observed observe VBN cord-005453-4057qib7 12342 22 ( ( -LRB- cord-005453-4057qib7 12342 23 median median NN cord-005453-4057qib7 12342 24 at at IN cord-005453-4057qib7 12342 25 the the DT cord-005453-4057qib7 12342 26 11 11 CD cord-005453-4057qib7 12342 27 th th XX cord-005453-4057qib7 12342 28 Infusion Infusion NNP cord-005453-4057qib7 12342 29 ) ) -RRB- cord-005453-4057qib7 12342 30 . . . cord-005453-4057qib7 12343 1 Results result NNS cord-005453-4057qib7 12343 2 : : : cord-005453-4057qib7 12344 1 The the DT cord-005453-4057qib7 12344 2 median median JJ cord-005453-4057qib7 12344 3 number number NN cord-005453-4057qib7 12344 4 of of IN cord-005453-4057qib7 12344 5 infusions infusion NNS cord-005453-4057qib7 12344 6 was be VBD cord-005453-4057qib7 12344 7 14 14 CD cord-005453-4057qib7 12344 8 . . . cord-005453-4057qib7 12345 1 Twenty twenty CD cord-005453-4057qib7 12345 2 adverse adverse JJ cord-005453-4057qib7 12345 3 reactions reaction NNS cord-005453-4057qib7 12345 4 were be VBD cord-005453-4057qib7 12345 5 observed observe VBN cord-005453-4057qib7 12345 6 in in IN cord-005453-4057qib7 12345 7 13 13 CD cord-005453-4057qib7 12345 8 of of IN cord-005453-4057qib7 12345 9 22 22 CD cord-005453-4057qib7 12345 10 ( ( -LRB- cord-005453-4057qib7 12345 11 59 59 CD cord-005453-4057qib7 12345 12 % % NN cord-005453-4057qib7 12345 13 ) ) -RRB- cord-005453-4057qib7 12345 14 patients patient NNS cord-005453-4057qib7 12345 15 : : : cord-005453-4057qib7 12345 16 dyspnea dyspnea NNP cord-005453-4057qib7 12345 17 ( ( -LRB- cord-005453-4057qib7 12345 18 n=5 n=5 NNP cord-005453-4057qib7 12345 19 ) ) -RRB- cord-005453-4057qib7 12345 20 , , . cord-005453-4057qib7 12346 1 bronchospasm bronchospasm JJ cord-005453-4057qib7 12346 2 ( ( -LRB- cord-005453-4057qib7 12346 3 n=2 n=2 NNS cord-005453-4057qib7 12346 4 ) ) -RRB- cord-005453-4057qib7 12347 1 shivering shiver VBG cord-005453-4057qib7 12347 2 ( ( -LRB- cord-005453-4057qib7 12347 3 n=3 n=3 NN cord-005453-4057qib7 12347 4 ) ) -RRB- cord-005453-4057qib7 12347 5 , , , cord-005453-4057qib7 12347 6 cough cough NN cord-005453-4057qib7 12347 7 ( ( -LRB- cord-005453-4057qib7 12347 8 n=2 n=2 NNS cord-005453-4057qib7 12347 9 ) ) -RRB- cord-005453-4057qib7 12347 10 , , , cord-005453-4057qib7 12347 11 musculoskeletal musculoskeletal JJ cord-005453-4057qib7 12347 12 pain pain NN cord-005453-4057qib7 12347 13 ( ( -LRB- cord-005453-4057qib7 12347 14 n=4 n=4 NNP cord-005453-4057qib7 12347 15 ) ) -RRB- cord-005453-4057qib7 12347 16 , , , cord-005453-4057qib7 12347 17 acute acute JJ cord-005453-4057qib7 12347 18 coronary coronary JJ cord-005453-4057qib7 12347 19 syndrome syndrome NN cord-005453-4057qib7 12347 20 ( ( -LRB- cord-005453-4057qib7 12347 21 n=1 n=1 CD cord-005453-4057qib7 12347 22 ) ) -RRB- cord-005453-4057qib7 12347 23 , , , cord-005453-4057qib7 12347 24 skin skin NN cord-005453-4057qib7 12347 25 rush rush NN cord-005453-4057qib7 12347 26 ( ( -LRB- cord-005453-4057qib7 12347 27 n=1 n=1 FW cord-005453-4057qib7 12347 28 ) ) -RRB- cord-005453-4057qib7 12347 29 , , , cord-005453-4057qib7 12347 30 facial facial JJ cord-005453-4057qib7 12347 31 edema edema NN cord-005453-4057qib7 12347 32 ( ( -LRB- cord-005453-4057qib7 12347 33 n=1 n=1 FW cord-005453-4057qib7 12347 34 ) ) -RRB- cord-005453-4057qib7 12347 35 , , , cord-005453-4057qib7 12347 36 pressure pressure NN cord-005453-4057qib7 12347 37 on on IN cord-005453-4057qib7 12347 38 eyes eye NNS cord-005453-4057qib7 12347 39 ( ( -LRB- cord-005453-4057qib7 12347 40 n=1 n=1 NN cord-005453-4057qib7 12347 41 ) ) -RRB- cord-005453-4057qib7 12347 42 . . . cord-005453-4057qib7 12348 1 All all DT cord-005453-4057qib7 12348 2 adverse adverse JJ cord-005453-4057qib7 12348 3 reactions reaction NNS cord-005453-4057qib7 12348 4 appeared appear VBD cord-005453-4057qib7 12348 5 during during IN cord-005453-4057qib7 12348 6 the the DT cord-005453-4057qib7 12348 7 first first JJ cord-005453-4057qib7 12348 8 infusion infusion NN cord-005453-4057qib7 12348 9 and and CC cord-005453-4057qib7 12348 10 were be VBD cord-005453-4057qib7 12348 11 mostly mostly RB cord-005453-4057qib7 12348 12 mild mild JJ cord-005453-4057qib7 12348 13 or or CC cord-005453-4057qib7 12348 14 moderate moderate JJ cord-005453-4057qib7 12348 15 ( ( -LRB- cord-005453-4057qib7 12348 16 CTC CTC NNP cord-005453-4057qib7 12348 17 1 1 CD cord-005453-4057qib7 12348 18 - - SYM cord-005453-4057qib7 12348 19 2 2 CD cord-005453-4057qib7 12348 20 , , , cord-005453-4057qib7 12348 21 n=19 n=19 NN cord-005453-4057qib7 12348 22 ) ) -RRB- cord-005453-4057qib7 12348 23 . . . cord-005453-4057qib7 12349 1 Tolerance tolerance NN cord-005453-4057qib7 12349 2 of of IN cord-005453-4057qib7 12349 3 the the DT cord-005453-4057qib7 12349 4 following follow VBG cord-005453-4057qib7 12349 5 infusions infusion NNS cord-005453-4057qib7 12349 6 improved improve VBN cord-005453-4057qib7 12349 7 and and CC cord-005453-4057qib7 12349 8 in in IN cord-005453-4057qib7 12349 9 none none NN cord-005453-4057qib7 12349 10 of of IN cord-005453-4057qib7 12349 11 the the DT cord-005453-4057qib7 12349 12 cases case NNS cord-005453-4057qib7 12349 13 therapy therapy NN cord-005453-4057qib7 12349 14 had have VBD cord-005453-4057qib7 12349 15 to to TO cord-005453-4057qib7 12349 16 be be VB cord-005453-4057qib7 12349 17 stopped stop VBN cord-005453-4057qib7 12349 18 due due JJ cord-005453-4057qib7 12349 19 to to IN cord-005453-4057qib7 12349 20 adverse adverse JJ cord-005453-4057qib7 12349 21 events event NNS cord-005453-4057qib7 12349 22 . . . cord-005453-4057qib7 12350 1 Three three CD cord-005453-4057qib7 12350 2 patients patient NNS cord-005453-4057qib7 12350 3 developed develop VBD cord-005453-4057qib7 12350 4 late late JJ cord-005453-4057qib7 12350 5 onset onset NN cord-005453-4057qib7 12350 6 infections infection NNS cord-005453-4057qib7 12350 7 ( ( -LRB- cord-005453-4057qib7 12350 8 pneumonia pneumonia NN cord-005453-4057qib7 12350 9 , , , cord-005453-4057qib7 12350 10 n=2 n=2 NNS cord-005453-4057qib7 12350 11 ; ; : cord-005453-4057qib7 12350 12 urinary urinary JJ cord-005453-4057qib7 12350 13 tract tract NN cord-005453-4057qib7 12350 14 infection infection NN cord-005453-4057qib7 12350 15 , , , cord-005453-4057qib7 12350 16 n=1 n=1 CD cord-005453-4057qib7 12350 17 ) ) -RRB- cord-005453-4057qib7 12350 18 followed follow VBN cord-005453-4057qib7 12350 19 by by IN cord-005453-4057qib7 12350 20 temporarily temporarily RB cord-005453-4057qib7 12350 21 therapy therapy NN cord-005453-4057qib7 12350 22 interruption interruption NN cord-005453-4057qib7 12350 23 . . . cord-005453-4057qib7 12351 1 With with IN cord-005453-4057qib7 12351 2 a a DT cord-005453-4057qib7 12351 3 median median JJ cord-005453-4057qib7 12351 4 follow follow NN cord-005453-4057qib7 12351 5 - - HYPH cord-005453-4057qib7 12351 6 up up NN cord-005453-4057qib7 12351 7 of of IN cord-005453-4057qib7 12351 8 14 14 CD cord-005453-4057qib7 12351 9 months month NNS cord-005453-4057qib7 12351 10 after after IN cord-005453-4057qib7 12351 11 the the DT cord-005453-4057qib7 12351 12 first first JJ cord-005453-4057qib7 12351 13 administration administration NN cord-005453-4057qib7 12351 14 20 20 CD cord-005453-4057qib7 12351 15 of of IN cord-005453-4057qib7 12351 16 22 22 CD cord-005453-4057qib7 12351 17 patients patient NNS cord-005453-4057qib7 12351 18 remain remain VBP cord-005453-4057qib7 12351 19 alive alive JJ cord-005453-4057qib7 12351 20 .9 .9 CD cord-005453-4057qib7 12351 21 % % NN cord-005453-4057qib7 12351 22 ) ) -RRB- cord-005453-4057qib7 12351 23 . . . cord-005453-4057qib7 12352 1 One one CD cord-005453-4057qib7 12352 2 patient patient NN cord-005453-4057qib7 12352 3 died die VBD cord-005453-4057qib7 12352 4 due due IN cord-005453-4057qib7 12352 5 to to IN cord-005453-4057qib7 12352 6 progress progress NN cord-005453-4057qib7 12352 7 of of IN cord-005453-4057qib7 12352 8 myeloma myeloma NN cord-005453-4057qib7 12352 9 and and CC cord-005453-4057qib7 12352 10 another another DT cord-005453-4057qib7 12352 11 died die VBD cord-005453-4057qib7 12352 12 due due JJ cord-005453-4057qib7 12352 13 to to IN cord-005453-4057qib7 12352 14 severe severe JJ cord-005453-4057qib7 12352 15 infection infection NN cord-005453-4057qib7 12352 16 / / SYM cord-005453-4057qib7 12352 17 sepsis sepsis NN cord-005453-4057qib7 12352 18 . . . cord-005453-4057qib7 12353 1 15 15 CD cord-005453-4057qib7 12353 2 of of IN cord-005453-4057qib7 12353 3 22 22 CD cord-005453-4057qib7 12353 4 patients patient NNS cord-005453-4057qib7 12353 5 responded respond VBD cord-005453-4057qib7 12353 6 ( ( -LRB- cord-005453-4057qib7 12353 7 68 68 CD cord-005453-4057qib7 12353 8 % % NN cord-005453-4057qib7 12353 9 ; ; : cord-005453-4057qib7 12353 10 PR PR NNP cord-005453-4057qib7 12353 11 , , , cord-005453-4057qib7 12353 12 n=5 n=5 JJ cord-005453-4057qib7 12353 13 ; ; : cord-005453-4057qib7 12353 14 vgPR vgpr NN cord-005453-4057qib7 12353 15 , , , cord-005453-4057qib7 12353 16 n=8 n=8 NN cord-005453-4057qib7 12353 17 ; ; : cord-005453-4057qib7 12353 18 CR cr NN cord-005453-4057qib7 12353 19 , , , cord-005453-4057qib7 12353 20 n=2 n=2 NNS cord-005453-4057qib7 12353 21 ) ) -RRB- cord-005453-4057qib7 12353 22 to to IN cord-005453-4057qib7 12353 23 the the DT cord-005453-4057qib7 12353 24 therapy therapy NN cord-005453-4057qib7 12353 25 with with IN cord-005453-4057qib7 12353 26 daratumumab daratumumab NNP cord-005453-4057qib7 12353 27 . . . cord-005453-4057qib7 12354 1 The the DT cord-005453-4057qib7 12354 2 responses response NNS cord-005453-4057qib7 12354 3 ( ( -LRB- cord-005453-4057qib7 12354 4 decrease decrease NN cord-005453-4057qib7 12354 5 of of IN cord-005453-4057qib7 12354 6 paraprotein paraprotein NNP cord-005453-4057qib7 12354 7 and/or and/or CC cord-005453-4057qib7 12354 8 free free JJ cord-005453-4057qib7 12354 9 light light JJ cord-005453-4057qib7 12354 10 chains chain NNS cord-005453-4057qib7 12354 11 ≥50 ≥50 DT cord-005453-4057qib7 12354 12 % % NN cord-005453-4057qib7 12354 13 ) ) -RRB- cord-005453-4057qib7 12354 14 occurred occur VBD cord-005453-4057qib7 12354 15 at at IN cord-005453-4057qib7 12354 16 a a DT cord-005453-4057qib7 12354 17 median median NN cord-005453-4057qib7 12354 18 of of IN cord-005453-4057qib7 12354 19 7 7 CD cord-005453-4057qib7 12354 20 days day NNS cord-005453-4057qib7 12354 21 ( ( -LRB- cord-005453-4057qib7 12354 22 4 4 CD cord-005453-4057qib7 12354 23 - - SYM cord-005453-4057qib7 12354 24 372 372 CD cord-005453-4057qib7 12354 25 ) ) -RRB- cord-005453-4057qib7 12354 26 after after IN cord-005453-4057qib7 12354 27 the the DT cord-005453-4057qib7 12354 28 first first JJ cord-005453-4057qib7 12354 29 administration administration NN cord-005453-4057qib7 12354 30 and and CC cord-005453-4057qib7 12354 31 lasted last VBD cord-005453-4057qib7 12354 32 for for IN cord-005453-4057qib7 12354 33 5.0 5.0 CD cord-005453-4057qib7 12354 34 months month NNS cord-005453-4057qib7 12354 35 ( ( -LRB- cord-005453-4057qib7 12354 36 0.5 0.5 CD cord-005453-4057qib7 12354 37 - - SYM cord-005453-4057qib7 12354 38 26.6 26.6 CD cord-005453-4057qib7 12354 39 ) ) -RRB- cord-005453-4057qib7 12354 40 . . . cord-005453-4057qib7 12355 1 Conclusions conclusion NNS cord-005453-4057qib7 12355 2 : : : cord-005453-4057qib7 12356 1 Daratumumab Daratumumab NNP cord-005453-4057qib7 12356 2 shows show VBZ cord-005453-4057qib7 12356 3 an an DT cord-005453-4057qib7 12356 4 encouraging encourage VBG cord-005453-4057qib7 12356 5 efficacy efficacy NN cord-005453-4057qib7 12356 6 and and CC cord-005453-4057qib7 12356 7 acceptable acceptable JJ cord-005453-4057qib7 12356 8 toxicity toxicity NN cord-005453-4057qib7 12356 9 profile profile NN cord-005453-4057qib7 12356 10 in in IN cord-005453-4057qib7 12356 11 patients patient NNS cord-005453-4057qib7 12356 12 with with IN cord-005453-4057qib7 12356 13 relapsed relapse VBN cord-005453-4057qib7 12356 14 / / SYM cord-005453-4057qib7 12356 15 refractory refractory JJ cord-005453-4057qib7 12356 16 myeloma myeloma NN cord-005453-4057qib7 12356 17 after after IN cord-005453-4057qib7 12356 18 allo allo NN cord-005453-4057qib7 12356 19 - - HYPH cord-005453-4057qib7 12356 20 SCT SCT NNP cord-005453-4057qib7 12356 21 . . . cord-005453-4057qib7 12357 1 Further further JJ cord-005453-4057qib7 12357 2 studies study NNS cord-005453-4057qib7 12357 3 are be VBP cord-005453-4057qib7 12357 4 needed need VBN cord-005453-4057qib7 12357 5 to to TO cord-005453-4057qib7 12357 6 investigate investigate VB cord-005453-4057qib7 12357 7 the the DT cord-005453-4057qib7 12357 8 role role NN cord-005453-4057qib7 12357 9 of of IN cord-005453-4057qib7 12357 10 the the DT cord-005453-4057qib7 12357 11 combination combination NN cord-005453-4057qib7 12357 12 therapy therapy NN cord-005453-4057qib7 12357 13 with with IN cord-005453-4057qib7 12357 14 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 12357 15 drugs drug NNS cord-005453-4057qib7 12357 16 or or CC cord-005453-4057qib7 12357 17 proteasome proteasome NN cord-005453-4057qib7 12357 18 inhibitors inhibitor NNS cord-005453-4057qib7 12357 19 in in IN cord-005453-4057qib7 12357 20 this this DT cord-005453-4057qib7 12357 21 setting setting NN cord-005453-4057qib7 12357 22 . . . cord-005453-4057qib7 12358 1 Disclosure disclosure NN cord-005453-4057qib7 12358 2 : : : cord-005453-4057qib7 12358 3 Nothing nothing NN cord-005453-4057qib7 12358 4 to to TO cord-005453-4057qib7 12358 5 declare declare VB cord-005453-4057qib7 12358 6 P546 P546 NNP cord-005453-4057qib7 12359 1 Clonal Clonal NNP cord-005453-4057qib7 12359 2 plasma plasma NN cord-005453-4057qib7 12359 3 cell cell NN cord-005453-4057qib7 12359 4 detection detection NN cord-005453-4057qib7 12359 5 by by IN cord-005453-4057qib7 12359 6 high high JJ cord-005453-4057qib7 12359 7 sensitive sensitive JJ cord-005453-4057qib7 12359 8 flow flow NN cord-005453-4057qib7 12359 9 cytometry cytometry NN cord-005453-4057qib7 12359 10 in in IN cord-005453-4057qib7 12359 11 aphaeresis aphaeresis NN cord-005453-4057qib7 12359 12 product product NN cord-005453-4057qib7 12359 13 is be VBZ cord-005453-4057qib7 12359 14 poor poor JJ cord-005453-4057qib7 12359 15 prognostic prognostic JJ cord-005453-4057qib7 12359 16 and and CC cord-005453-4057qib7 12359 17 not not RB cord-005453-4057qib7 12359 18 increased increase VBN cord-005453-4057qib7 12359 19 by by IN cord-005453-4057qib7 12359 20 use use NN cord-005453-4057qib7 12359 21 of of IN cord-005453-4057qib7 12359 22 plerixafor plerixafor NN cord-005453-4057qib7 12359 23 alone alone RB cord-005453-4057qib7 12359 24 Background background NN cord-005453-4057qib7 12359 25 : : : cord-005453-4057qib7 12360 1 In in IN cord-005453-4057qib7 12360 2 an an DT cord-005453-4057qib7 12360 3 earlier early JJR cord-005453-4057qib7 12360 4 from from IN cord-005453-4057qib7 12360 5 our -PRON- PRP$ cord-005453-4057qib7 12360 6 center center NN cord-005453-4057qib7 12360 7 we -PRON- PRP cord-005453-4057qib7 12360 8 have have VBP cord-005453-4057qib7 12360 9 demonstrated demonstrate VBN cord-005453-4057qib7 12360 10 that that IN cord-005453-4057qib7 12360 11 residual residual JJ cord-005453-4057qib7 12360 12 clonal clonal JJ cord-005453-4057qib7 12360 13 plasma plasma NN cord-005453-4057qib7 12360 14 cells cell NNS cord-005453-4057qib7 12360 15 ( ( -LRB- cord-005453-4057qib7 12360 16 cPC cPC NNP cord-005453-4057qib7 12360 17 ) ) -RRB- cord-005453-4057qib7 12360 18 decrease decrease VB cord-005453-4057qib7 12360 19 both both DT cord-005453-4057qib7 12360 20 overall overall JJ cord-005453-4057qib7 12360 21 survival survival NN cord-005453-4057qib7 12360 22 ( ( -LRB- cord-005453-4057qib7 12360 23 OS OS NNP cord-005453-4057qib7 12360 24 ) ) -RRB- cord-005453-4057qib7 12360 25 and and CC cord-005453-4057qib7 12360 26 disease disease NNP cord-005453-4057qib7 12360 27 free free JJ cord-005453-4057qib7 12360 28 survival survival NN cord-005453-4057qib7 12360 29 ( ( -LRB- cord-005453-4057qib7 12360 30 DFS DFS NNP cord-005453-4057qib7 12360 31 ) ) -RRB- cord-005453-4057qib7 12361 1 ( ( -LRB- cord-005453-4057qib7 12361 2 ASH ASH NNP cord-005453-4057qib7 12361 3 2018).Plerixafor 2018).plerixafor CD cord-005453-4057qib7 12361 4 is be VBZ cord-005453-4057qib7 12361 5 a a DT cord-005453-4057qib7 12361 6 selective selective JJ cord-005453-4057qib7 12361 7 antagonist antagonist NN cord-005453-4057qib7 12361 8 of of IN cord-005453-4057qib7 12361 9 CXC4 CXC4 NNP cord-005453-4057qib7 12361 10 chemokine chemokine NN cord-005453-4057qib7 12361 11 receptor receptor NN cord-005453-4057qib7 12361 12 ( ( -LRB- cord-005453-4057qib7 12361 13 CXCR4 CXCR4 NNP cord-005453-4057qib7 12361 14 ) ) -RRB- cord-005453-4057qib7 12361 15 and and CC cord-005453-4057qib7 12361 16 able able JJ cord-005453-4057qib7 12361 17 to to TO cord-005453-4057qib7 12361 18 mobilize mobilize VB cord-005453-4057qib7 12361 19 human human JJ cord-005453-4057qib7 12361 20 peripheral peripheral JJ cord-005453-4057qib7 12361 21 blood blood NN cord-005453-4057qib7 12361 22 stem stem NN cord-005453-4057qib7 12361 23 cell cell NN cord-005453-4057qib7 12361 24 ( ( -LRB- cord-005453-4057qib7 12361 25 PBSCs pbsc NNS cord-005453-4057qib7 12361 26 ) ) -RRB- cord-005453-4057qib7 12361 27 by by IN cord-005453-4057qib7 12361 28 acting act VBG cord-005453-4057qib7 12361 29 synergistically synergistically RB cord-005453-4057qib7 12361 30 with with IN cord-005453-4057qib7 12361 31 G G NNP cord-005453-4057qib7 12361 32 - - HYPH cord-005453-4057qib7 12361 33 CSF.The CSF.The NNP cord-005453-4057qib7 12361 34 purpose purpose NN cord-005453-4057qib7 12361 35 of of IN cord-005453-4057qib7 12361 36 this this DT cord-005453-4057qib7 12361 37 study study NN cord-005453-4057qib7 12361 38 was be VBD cord-005453-4057qib7 12361 39 to to TO cord-005453-4057qib7 12361 40 evaluate evaluate VB cord-005453-4057qib7 12361 41 the the DT cord-005453-4057qib7 12361 42 safety safety NN cord-005453-4057qib7 12361 43 and and CC cord-005453-4057qib7 12361 44 efficacy efficacy NN cord-005453-4057qib7 12361 45 of of IN cord-005453-4057qib7 12361 46 plerixafor plerixafor NN cord-005453-4057qib7 12361 47 in in IN cord-005453-4057qib7 12361 48 myeloma myeloma NN cord-005453-4057qib7 12361 49 patients patient NNS cord-005453-4057qib7 12361 50 who who WP cord-005453-4057qib7 12361 51 were be VBD cord-005453-4057qib7 12361 52 proven prove VBN cord-005453-4057qib7 12361 53 poor poor JJ cord-005453-4057qib7 12361 54 mobilizers mobilizer NNS cord-005453-4057qib7 12361 55 and and CC cord-005453-4057qib7 12361 56 specifically specifically RB cord-005453-4057qib7 12361 57 to to TO cord-005453-4057qib7 12361 58 assess assess VB cord-005453-4057qib7 12361 59 the the DT cord-005453-4057qib7 12361 60 flow flow NN cord-005453-4057qib7 12361 61 cytometric cytometric NN cord-005453-4057qib7 12361 62 measurement measurement NN cord-005453-4057qib7 12361 63 of of IN cord-005453-4057qib7 12361 64 residual residual JJ cord-005453-4057qib7 12361 65 clonal clonal JJ cord-005453-4057qib7 12361 66 plasma plasma NN cord-005453-4057qib7 12361 67 cells cell NNS cord-005453-4057qib7 12361 68 in in IN cord-005453-4057qib7 12361 69 the the DT cord-005453-4057qib7 12361 70 apheresis apheresis NN cord-005453-4057qib7 12361 71 products product NNS cord-005453-4057qib7 12361 72 . . . cord-005453-4057qib7 12362 1 Methods method NNS cord-005453-4057qib7 12362 2 : : : cord-005453-4057qib7 12362 3 Patients patient NNS cord-005453-4057qib7 12362 4 with with IN cord-005453-4057qib7 12362 5 a a DT cord-005453-4057qib7 12362 6 diagnosis diagnosis NN cord-005453-4057qib7 12362 7 of of IN cord-005453-4057qib7 12362 8 MM MM NNP cord-005453-4057qib7 12362 9 who who WP cord-005453-4057qib7 12362 10 underwent undergo VBD cord-005453-4057qib7 12362 11 auto auto NN cord-005453-4057qib7 12362 12 HSCT HSCT NNP cord-005453-4057qib7 12362 13 at at IN cord-005453-4057qib7 12362 14 our -PRON- PRP$ cord-005453-4057qib7 12362 15 center center NN cord-005453-4057qib7 12362 16 between between IN cord-005453-4057qib7 12362 17 January January NNP cord-005453-4057qib7 12362 18 2008-November 2008-november CD cord-005453-4057qib7 12362 19 2018 2018 CD cord-005453-4057qib7 12362 20 were be VBD cord-005453-4057qib7 12362 21 retrospectively retrospectively RB cord-005453-4057qib7 12362 22 analyzed analyze VBN cord-005453-4057qib7 12362 23 . . . cord-005453-4057qib7 12363 1 Out out IN cord-005453-4057qib7 12363 2 of of IN cord-005453-4057qib7 12363 3 164 164 CD cord-005453-4057qib7 12363 4 patients patient NNS cord-005453-4057qib7 12363 5 , , , cord-005453-4057qib7 12363 6 16 16 CD cord-005453-4057qib7 12363 7 patients patient NNS cord-005453-4057qib7 12363 8 received receive VBD cord-005453-4057qib7 12363 9 plerixafor plerixafor NN cord-005453-4057qib7 12363 10 as as IN cord-005453-4057qib7 12363 11 mobilization mobilization NN cord-005453-4057qib7 12363 12 regimen regimen NN cord-005453-4057qib7 12363 13 due due IN cord-005453-4057qib7 12363 14 to to IN cord-005453-4057qib7 12363 15 poor poor JJ cord-005453-4057qib7 12363 16 mobilization mobilization NN cord-005453-4057qib7 12363 17 with with IN cord-005453-4057qib7 12363 18 G g NN cord-005453-4057qib7 12363 19 - - HYPH cord-005453-4057qib7 12363 20 CSF.PBSC CSF.PBSC NNS cord-005453-4057qib7 12363 21 grafts graft NNS cord-005453-4057qib7 12363 22 were be VBD cord-005453-4057qib7 12363 23 tested test VBN cord-005453-4057qib7 12363 24 for for IN cord-005453-4057qib7 12363 25 the the DT cord-005453-4057qib7 12363 26 presence presence NN cord-005453-4057qib7 12363 27 of of IN cord-005453-4057qib7 12363 28 clonal clonal JJ cord-005453-4057qib7 12363 29 PCs pc NNS cord-005453-4057qib7 12363 30 ( ( -LRB- cord-005453-4057qib7 12363 31 cPC cPC NNP cord-005453-4057qib7 12363 32 ) ) -RRB- cord-005453-4057qib7 12363 33 and and CC cord-005453-4057qib7 12363 34 the the DT cord-005453-4057qib7 12363 35 number number NN cord-005453-4057qib7 12363 36 of of IN cord-005453-4057qib7 12363 37 normal normal JJ cord-005453-4057qib7 12363 38 PCs pc NNS cord-005453-4057qib7 12363 39 ( ( -LRB- cord-005453-4057qib7 12363 40 NPC NPC NNP cord-005453-4057qib7 12363 41 ) ) -RRB- cord-005453-4057qib7 12363 42 by by IN cord-005453-4057qib7 12363 43 multi multi JJ cord-005453-4057qib7 12363 44 - - JJ cord-005453-4057qib7 12363 45 parameter parameter JJ cord-005453-4057qib7 12363 46 flow flow NN cord-005453-4057qib7 12363 47 cytometry cytometry NN cord-005453-4057qib7 12363 48 ( ( -LRB- cord-005453-4057qib7 12363 49 FCM).The fcm).the CD cord-005453-4057qib7 12363 50 acquisition acquisition NN cord-005453-4057qib7 12363 51 of of IN cord-005453-4057qib7 12363 52 the the DT cord-005453-4057qib7 12363 53 cells cell NNS cord-005453-4057qib7 12363 54 was be VBD cord-005453-4057qib7 12363 55 performed perform VBN cord-005453-4057qib7 12363 56 using use VBG cord-005453-4057qib7 12363 57 the the DT cord-005453-4057qib7 12363 58 Navios Navios NNPS cord-005453-4057qib7 12363 59 Flow Flow NNP cord-005453-4057qib7 12363 60 cytometer cytometer NN cord-005453-4057qib7 12363 61 BeckmanCoulter BeckmanCoulter NNP cord-005453-4057qib7 12363 62 ) ) -RRB- cord-005453-4057qib7 12363 63 .Upon .Upon . cord-005453-4057qib7 12364 1 the the DT cord-005453-4057qib7 12364 2 daily daily JJ cord-005453-4057qib7 12364 3 checks check NNS cord-005453-4057qib7 12364 4 of of IN cord-005453-4057qib7 12364 5 the the DT cord-005453-4057qib7 12364 6 instrument instrument NN cord-005453-4057qib7 12364 7 , , , cord-005453-4057qib7 12364 8 3x10 3x10 CD cord-005453-4057qib7 12364 9 6 6 CD cord-005453-4057qib7 12364 10 cells cell NNS cord-005453-4057qib7 12364 11 for for IN cord-005453-4057qib7 12364 12 each each DT cord-005453-4057qib7 12364 13 sample sample NN cord-005453-4057qib7 12364 14 were be VBD cord-005453-4057qib7 12364 15 acquired acquire VBN cord-005453-4057qib7 12364 16 and and CC cord-005453-4057qib7 12364 17 the the DT cord-005453-4057qib7 12364 18 collected collect VBN cord-005453-4057qib7 12364 19 data datum NNS cord-005453-4057qib7 12364 20 was be VBD cord-005453-4057qib7 12364 21 analyzed analyze VBN cord-005453-4057qib7 12364 22 using use VBG cord-005453-4057qib7 12364 23 the the DT cord-005453-4057qib7 12364 24 Kaluza Kaluza NNP cord-005453-4057qib7 12364 25 software software NN cord-005453-4057qib7 12364 26 ( ( -LRB- cord-005453-4057qib7 12364 27 BeckmanCoulter BeckmanCoulter NNP cord-005453-4057qib7 12364 28 , , , cord-005453-4057qib7 12364 29 USA USA NNP cord-005453-4057qib7 12364 30 ) ) -RRB- cord-005453-4057qib7 12364 31 . . . cord-005453-4057qib7 12365 1 Results result NNS cord-005453-4057qib7 12365 2 : : : cord-005453-4057qib7 12366 1 Patient patient JJ cord-005453-4057qib7 12366 2 demographics demographic NNS cord-005453-4057qib7 12366 3 are be VBP cord-005453-4057qib7 12366 4 shown show VBN cord-005453-4057qib7 12366 5 in in IN cord-005453-4057qib7 12366 6 Table table NN cord-005453-4057qib7 12367 1 1 1 LS cord-005453-4057qib7 12367 2 .The .the CD cord-005453-4057qib7 12367 3 majority majority NN cord-005453-4057qib7 12367 4 of of IN cord-005453-4057qib7 12367 5 patients patient NNS cord-005453-4057qib7 12367 6 were be VBD cord-005453-4057qib7 12368 1 male male JJ cord-005453-4057qib7 12368 2 and and CC cord-005453-4057qib7 12368 3 median median JJ cord-005453-4057qib7 12368 4 age age NN cord-005453-4057qib7 12368 5 was be VBD cord-005453-4057qib7 12368 6 62 62 CD cord-005453-4057qib7 12368 7 years year NNS cord-005453-4057qib7 12368 8 in in IN cord-005453-4057qib7 12368 9 the the DT cord-005453-4057qib7 12368 10 plerixafor plerixafor NN cord-005453-4057qib7 12368 11 group group NN cord-005453-4057qib7 12368 12 . . . cord-005453-4057qib7 12369 1 The the DT cord-005453-4057qib7 12369 2 median median JJ cord-005453-4057qib7 12369 3 interval interval NN cord-005453-4057qib7 12369 4 from from IN cord-005453-4057qib7 12369 5 time time NN cord-005453-4057qib7 12369 6 of of IN cord-005453-4057qib7 12369 7 diagnosis diagnosis NN cord-005453-4057qib7 12369 8 to to IN cord-005453-4057qib7 12369 9 mobilization mobilization NN cord-005453-4057qib7 12369 10 and and CC cord-005453-4057qib7 12369 11 follow follow NN cord-005453-4057qib7 12369 12 - - HYPH cord-005453-4057qib7 12369 13 up up NN cord-005453-4057qib7 12369 14 from from IN cord-005453-4057qib7 12369 15 mobilization mobilization NN cord-005453-4057qib7 12369 16 were be VBD cord-005453-4057qib7 12369 17 3.3 3.3 CD cord-005453-4057qib7 12369 18 months month NNS cord-005453-4057qib7 12369 19 and and CC cord-005453-4057qib7 12369 20 14.3 14.3 CD cord-005453-4057qib7 12369 21 months month NNS cord-005453-4057qib7 12369 22 in in IN cord-005453-4057qib7 12369 23 plerixafor plerixafor NN cord-005453-4057qib7 12369 24 group group NN cord-005453-4057qib7 12369 25 , , , cord-005453-4057qib7 12369 26 respectively respectively RB cord-005453-4057qib7 12369 27 . . . cord-005453-4057qib7 12370 1 cPC cPC NNP cord-005453-4057qib7 12370 2 contamination contamination NN cord-005453-4057qib7 12370 3 in in IN cord-005453-4057qib7 12370 4 the the DT cord-005453-4057qib7 12370 5 PBSC PBSC NNP cord-005453-4057qib7 12370 6 grafts graft NNS cord-005453-4057qib7 12370 7 was be VBD cord-005453-4057qib7 12370 8 detectable detectable JJ cord-005453-4057qib7 12370 9 in in IN cord-005453-4057qib7 12370 10 32 32 CD cord-005453-4057qib7 12370 11 and and CC cord-005453-4057qib7 12370 12 7 7 CD cord-005453-4057qib7 12370 13 patients patient NNS cord-005453-4057qib7 12370 14 with with IN cord-005453-4057qib7 12370 15 counts count NNS cord-005453-4057qib7 12370 16 ranging range VBG cord-005453-4057qib7 12370 17 between between IN cord-005453-4057qib7 12370 18 0 0 CD cord-005453-4057qib7 12370 19 - - HYPH cord-005453-4057qib7 12370 20 8.7x10 8.7x10 CD cord-005453-4057qib7 12370 21 -5 -5 CD cord-005453-4057qib7 12370 22 and and CC cord-005453-4057qib7 12370 23 0 0 CD cord-005453-4057qib7 12370 24 - - HYPH cord-005453-4057qib7 12370 25 0.1x10 0.1x10 CD cord-005453-4057qib7 12370 26 -5 -5 CD cord-005453-4057qib7 12370 27 in in IN cord-005453-4057qib7 12370 28 G G NNP cord-005453-4057qib7 12370 29 - - HYPH cord-005453-4057qib7 12370 30 CSF csf NN cord-005453-4057qib7 12370 31 alone alone RB cord-005453-4057qib7 12370 32 and and CC cord-005453-4057qib7 12370 33 G g NN cord-005453-4057qib7 12370 34 - - HYPH cord-005453-4057qib7 12370 35 CSF+Plerixafor csf+plerixafor NN cord-005453-4057qib7 12370 36 groups group NNS cord-005453-4057qib7 12370 37 , , , cord-005453-4057qib7 12370 38 respectively respectively RB cord-005453-4057qib7 12370 39 ( ( -LRB- cord-005453-4057qib7 12370 40 p=0.116).There p=0.116).there EX cord-005453-4057qib7 12370 41 were be VBD cord-005453-4057qib7 12370 42 no no DT cord-005453-4057qib7 12370 43 significant significant JJ cord-005453-4057qib7 12370 44 differences difference NNS cord-005453-4057qib7 12370 45 in in IN cord-005453-4057qib7 12370 46 the the DT cord-005453-4057qib7 12370 47 proportion proportion NN cord-005453-4057qib7 12370 48 of of IN cord-005453-4057qib7 12370 49 the the DT cord-005453-4057qib7 12370 50 patients patient NNS cord-005453-4057qib7 12370 51 with with IN cord-005453-4057qib7 12370 52 graft graft NN cord-005453-4057qib7 12370 53 contamination contamination NN cord-005453-4057qib7 12370 54 between between IN cord-005453-4057qib7 12370 55 subtypes subtype NNS cord-005453-4057qib7 12370 56 of of IN cord-005453-4057qib7 12370 57 MM MM NNP cord-005453-4057qib7 12370 58 in in IN cord-005453-4057qib7 12370 59 both both DT cord-005453-4057qib7 12370 60 groups group NNS cord-005453-4057qib7 12370 61 . . . cord-005453-4057qib7 12371 1 One one CD cord-005453-4057qib7 12371 2 hundred hundred CD cord-005453-4057qib7 12372 1 ( ( -LRB- cord-005453-4057qib7 12372 2 GCSF GCSF NNP cord-005453-4057qib7 12372 3 / / SYM cord-005453-4057qib7 12372 4 plerixafor;93/7 plerixafor;93/7 NNP cord-005453-4057qib7 12372 5 ) ) -RRB- cord-005453-4057qib7 12372 6 patients patient NNS cord-005453-4057qib7 12372 7 had have VBD cord-005453-4057qib7 12372 8 pre pre JJ cord-005453-4057qib7 12372 9 - - JJ cord-005453-4057qib7 12372 10 ASCT asct JJ cord-005453-4057qib7 12372 11 PET PET NNP cord-005453-4057qib7 12372 12 - - HYPH cord-005453-4057qib7 12372 13 CT CT NNP cord-005453-4057qib7 12372 14 imaging imaging NN cord-005453-4057qib7 12372 15 done do VBN cord-005453-4057qib7 12372 16 with with IN cord-005453-4057qib7 12372 17 71 71 CD cord-005453-4057qib7 12373 1 ( ( -LRB- cord-005453-4057qib7 12373 2 GCSF GCSF NNP cord-005453-4057qib7 12373 3 / / SYM cord-005453-4057qib7 12373 4 plerixafor;64/7 plerixafor;64/7 NNP cord-005453-4057qib7 12373 5 ) ) -RRB- cord-005453-4057qib7 12373 6 have have VBP cord-005453-4057qib7 12373 7 active active JJ cord-005453-4057qib7 12373 8 lesion lesion NN cord-005453-4057qib7 12373 9 at at IN cord-005453-4057qib7 12373 10 the the DT cord-005453-4057qib7 12373 11 time time NN cord-005453-4057qib7 12373 12 of of IN cord-005453-4057qib7 12373 13 mobilization mobilization NN cord-005453-4057qib7 12373 14 . . . cord-005453-4057qib7 12374 1 Statistically statistically RB cord-005453-4057qib7 12374 2 significant significant JJ cord-005453-4057qib7 12374 3 association association NN cord-005453-4057qib7 12374 4 could could MD cord-005453-4057qib7 12374 5 not not RB cord-005453-4057qib7 12374 6 be be VB cord-005453-4057qib7 12374 7 demonstrated demonstrate VBN cord-005453-4057qib7 12374 8 between between IN cord-005453-4057qib7 12374 9 the the DT cord-005453-4057qib7 12374 10 disease disease NN cord-005453-4057qib7 12374 11 < < XX cord-005453-4057qib7 12374 12 CR CR NNP cord-005453-4057qib7 12374 13 status status NN cord-005453-4057qib7 12374 14 at at IN cord-005453-4057qib7 12374 15 mobilization mobilization NN cord-005453-4057qib7 12374 16 and and CC cord-005453-4057qib7 12374 17 the the DT cord-005453-4057qib7 12374 18 number number NN cord-005453-4057qib7 12374 19 of of IN cord-005453-4057qib7 12374 20 APC APC NNP cord-005453-4057qib7 12374 21 in in IN cord-005453-4057qib7 12374 22 the the DT cord-005453-4057qib7 12374 23 apheresis apheresis NN cord-005453-4057qib7 12374 24 product product NN cord-005453-4057qib7 12374 25 in in IN cord-005453-4057qib7 12374 26 both both DT cord-005453-4057qib7 12374 27 groups group NNS cord-005453-4057qib7 12374 28 ( ( -LRB- cord-005453-4057qib7 12374 29 p>0.05).Twelve p>0.05).twelve NN cord-005453-4057qib7 12374 30 of of IN cord-005453-4057qib7 12374 31 16 16 CD cord-005453-4057qib7 12374 32 patients patient NNS cord-005453-4057qib7 12374 33 from from IN cord-005453-4057qib7 12374 34 plerixafor plerixafor NN cord-005453-4057qib7 12374 35 treatment treatment NN cord-005453-4057qib7 12374 36 arm arm NN cord-005453-4057qib7 12374 37 proceeded proceed VBD cord-005453-4057qib7 12374 38 to to IN cord-005453-4057qib7 12374 39 transplantation transplantation NN cord-005453-4057qib7 12374 40 within within IN cord-005453-4057qib7 12374 41 median median NN cord-005453-4057qib7 12374 42 9.5 9.5 CD cord-005453-4057qib7 12374 43 months month NNS cord-005453-4057qib7 12374 44 . . . cord-005453-4057qib7 12375 1 The the DT cord-005453-4057qib7 12375 2 best good JJS cord-005453-4057qib7 12375 3 overall overall JJ cord-005453-4057qib7 12375 4 response response NN cord-005453-4057qib7 12375 5 to to IN cord-005453-4057qib7 12375 6 induction induction NN cord-005453-4057qib7 12375 7 treatment treatment NN cord-005453-4057qib7 12375 8 is be VBZ cord-005453-4057qib7 12375 9 shown show VBN cord-005453-4057qib7 12375 10 in in IN cord-005453-4057qib7 12375 11 Table table NN cord-005453-4057qib7 12375 12 1 1 CD cord-005453-4057qib7 12375 13 .Thirtyfour .thirtyfour CD cord-005453-4057qib7 12375 14 patients patient NNS cord-005453-4057qib7 12375 15 from from IN cord-005453-4057qib7 12375 16 the the DT cord-005453-4057qib7 12375 17 G G NNP cord-005453-4057qib7 12375 18 - - HYPH cord-005453-4057qib7 12375 19 CSF CSF NNP cord-005453-4057qib7 12375 20 alone alone RB cord-005453-4057qib7 12375 21 arm arm NN cord-005453-4057qib7 12375 22 and and CC cord-005453-4057qib7 12375 23 2 2 CD cord-005453-4057qib7 12375 24 patients patient NNS cord-005453-4057qib7 12375 25 from from IN cord-005453-4057qib7 12375 26 the the DT cord-005453-4057qib7 12375 27 G g NN cord-005453-4057qib7 12375 28 - - HYPH cord-005453-4057qib7 12375 29 CSF+plerixafor csf+plerixafor NN cord-005453-4057qib7 12375 30 arm arm NN cord-005453-4057qib7 12375 31 died die VBD cord-005453-4057qib7 12375 32 during during IN cord-005453-4057qib7 12375 33 the the DT cord-005453-4057qib7 12375 34 follow follow NN cord-005453-4057qib7 12375 35 - - HYPH cord-005453-4057qib7 12375 36 up up NN cord-005453-4057qib7 12375 37 ( ( -LRB- cord-005453-4057qib7 12375 38 p=0.52).Disease p=0.52).disease UH cord-005453-4057qib7 12375 39 progression progression NN cord-005453-4057qib7 12375 40 was be VBD cord-005453-4057qib7 12375 41 seen see VBN cord-005453-4057qib7 12375 42 in in IN cord-005453-4057qib7 12375 43 48 48 CD cord-005453-4057qib7 12375 44 patients patient NNS cord-005453-4057qib7 12375 45 from from IN cord-005453-4057qib7 12375 46 G G NNP cord-005453-4057qib7 12375 47 - - HYPH cord-005453-4057qib7 12375 48 CSF CSF NNP cord-005453-4057qib7 12375 49 alone alone RB cord-005453-4057qib7 12375 50 group group NN cord-005453-4057qib7 12375 51 and and CC cord-005453-4057qib7 12375 52 6 6 CD cord-005453-4057qib7 12375 53 patients patient NNS cord-005453-4057qib7 12375 54 from from IN cord-005453-4057qib7 12375 55 G g NN cord-005453-4057qib7 12375 56 - - HYPH cord-005453-4057qib7 12375 57 CSF+plerixafor csf+plerixafor NN cord-005453-4057qib7 12375 58 group group NN cord-005453-4057qib7 12375 59 of of IN cord-005453-4057qib7 12375 60 the the DT cord-005453-4057qib7 12376 1 study(p=0.56).Estimated study(p=0.56).Estimated NNP cord-005453-4057qib7 12376 2 mean mean NNP cord-005453-4057qib7 12376 3 OS OS NNP cord-005453-4057qib7 12376 4 was be VBD cord-005453-4057qib7 12376 5 better well JJR cord-005453-4057qib7 12376 6 among among IN cord-005453-4057qib7 12376 7 patients patient NNS cord-005453-4057qib7 12376 8 w/o without IN cord-005453-4057qib7 12376 9 aPC aPC NNP cord-005453-4057qib7 12376 10 contamination contamination NN cord-005453-4057qib7 12376 11 in in IN cord-005453-4057qib7 12376 12 plerixafor plerixafor NNP cord-005453-4057qib7 12376 13 group group NN cord-005453-4057qib7 12376 14 , , , cord-005453-4057qib7 12376 15 respectively respectively RB cord-005453-4057qib7 12376 16 ( ( -LRB- cord-005453-4057qib7 12376 17 38.9±5.3mos 38.9±5.3mos NNP cord-005453-4057qib7 12376 18 vs vs IN cord-005453-4057qib7 12376 19 16.8mos 16.8mos CD cord-005453-4057qib7 12376 20 ; ; : cord-005453-4057qib7 12376 21 p=0.52 p=0.52 NNP cord-005453-4057qib7 12376 22 ) ) -RRB- cord-005453-4057qib7 12376 23 . . . cord-005453-4057qib7 12377 1 Conclusions conclusion NNS cord-005453-4057qib7 12377 2 : : : cord-005453-4057qib7 12378 1 Our -PRON- PRP$ cord-005453-4057qib7 12378 2 results result NNS cord-005453-4057qib7 12378 3 on on IN cord-005453-4057qib7 12378 4 164 164 CD cord-005453-4057qib7 12378 5 and and CC cord-005453-4057qib7 12378 6 few few JJ cord-005453-4057qib7 12378 7 plerixafor plerixafor NN cord-005453-4057qib7 12379 1 used use VBN cord-005453-4057qib7 12379 2 patients patient NNS cord-005453-4057qib7 12379 3 show show VB cord-005453-4057qib7 12379 4 that that IN cord-005453-4057qib7 12379 5 clonal clonal JJ cord-005453-4057qib7 12379 6 plasma plasma NN cord-005453-4057qib7 12379 7 cells cell NNS cord-005453-4057qib7 12379 8 are be VBP cord-005453-4057qib7 12379 9 detectable detectable JJ cord-005453-4057qib7 12379 10 by by IN cord-005453-4057qib7 12379 11 multiparametric multiparametric JJ cord-005453-4057qib7 12379 12 flow flow NN cord-005453-4057qib7 12379 13 more more RBR cord-005453-4057qib7 12379 14 frequently frequently RB cord-005453-4057qib7 12379 15 when when WRB cord-005453-4057qib7 12379 16 patients patient NNS cord-005453-4057qib7 12379 17 are be VBP cord-005453-4057qib7 12379 18 poor poor JJ cord-005453-4057qib7 12379 19 mobilizers mobilizer NNS cord-005453-4057qib7 12379 20 and and CC cord-005453-4057qib7 12379 21 require require VB cord-005453-4057qib7 12379 22 plerixafor plerixafor NN cord-005453-4057qib7 12379 23 . . . cord-005453-4057qib7 12380 1 The the DT cord-005453-4057qib7 12380 2 clonal clonal JJ cord-005453-4057qib7 12380 3 PC pc NN cord-005453-4057qib7 12380 4 contamination contamination NN cord-005453-4057qib7 12380 5 can can MD cord-005453-4057qib7 12380 6 be be VB cord-005453-4057qib7 12380 7 attributed attribute VBN cord-005453-4057qib7 12380 8 to to IN cord-005453-4057qib7 12380 9 the the DT cord-005453-4057qib7 12380 10 myeloma myeloma NN cord-005453-4057qib7 12380 11 biology biology NN cord-005453-4057qib7 12380 12 as as IN cord-005453-4057qib7 12380 13 manifested manifest VBN cord-005453-4057qib7 12380 14 by by IN cord-005453-4057qib7 12380 15 higher high JJR cord-005453-4057qib7 12380 16 number number NN cord-005453-4057qib7 12380 17 of of IN cord-005453-4057qib7 12380 18 lines line NNS cord-005453-4057qib7 12380 19 induction induction NN cord-005453-4057qib7 12380 20 regimens regimen NNS cord-005453-4057qib7 12380 21 and and CC cord-005453-4057qib7 12380 22 PET pet JJ cord-005453-4057qib7 12380 23 positivity positivity NN cord-005453-4057qib7 12380 24 among among IN cord-005453-4057qib7 12380 25 the the DT cord-005453-4057qib7 12380 26 plerixafor plerixafor NN cord-005453-4057qib7 12380 27 - - HYPH cord-005453-4057qib7 12380 28 required require VBN cord-005453-4057qib7 12380 29 patients patient NNS cord-005453-4057qib7 12380 30 . . . cord-005453-4057qib7 12381 1 The the DT cord-005453-4057qib7 12381 2 overall overall JJ cord-005453-4057qib7 12381 3 and and CC cord-005453-4057qib7 12381 4 disease disease NN cord-005453-4057qib7 12381 5 survival survival NN cord-005453-4057qib7 12381 6 was be VBD cord-005453-4057qib7 12381 7 impaired impair VBN cord-005453-4057qib7 12381 8 by by IN cord-005453-4057qib7 12381 9 residual residual JJ cord-005453-4057qib7 12381 10 clonal clonal JJ cord-005453-4057qib7 12381 11 PCs pc NNS cord-005453-4057qib7 12381 12 in in IN cord-005453-4057qib7 12381 13 the the DT cord-005453-4057qib7 12381 14 graft graft NN cord-005453-4057qib7 12381 15 but but CC cord-005453-4057qib7 12381 16 not not RB cord-005453-4057qib7 12381 17 by by IN cord-005453-4057qib7 12381 18 plerixafor plerixafor NN cord-005453-4057qib7 12381 19 per per FW cord-005453-4057qib7 12381 20 se se FW cord-005453-4057qib7 12381 21 . . . cord-005453-4057qib7 12382 1 Neither neither DT cord-005453-4057qib7 12382 2 was be VBD cord-005453-4057qib7 12382 3 the the DT cord-005453-4057qib7 12382 4 content content NN cord-005453-4057qib7 12382 5 of of IN cord-005453-4057qib7 12382 6 clonal clonal JJ cord-005453-4057qib7 12382 7 PCs pc NNS cord-005453-4057qib7 12382 8 differed differ VBD cord-005453-4057qib7 12382 9 from from IN cord-005453-4057qib7 12382 10 others other NNS cord-005453-4057qib7 12382 11 . . . cord-005453-4057qib7 12383 1 Thus thus RB cord-005453-4057qib7 12383 2 the the DT cord-005453-4057qib7 12383 3 CXCR4 CXCR4 NNS cord-005453-4057qib7 12383 4 shared share VBN cord-005453-4057qib7 12383 5 by by IN cord-005453-4057qib7 12383 6 HSC HSC NNP cord-005453-4057qib7 12383 7 and and CC cord-005453-4057qib7 12383 8 myeloma myeloma NN cord-005453-4057qib7 12383 9 cells cell NNS cord-005453-4057qib7 12383 10 do do VBP cord-005453-4057qib7 12383 11 not not RB cord-005453-4057qib7 12383 12 cause cause VB cord-005453-4057qib7 12383 13 a a DT cord-005453-4057qib7 12383 14 myeloma myeloma NN cord-005453-4057qib7 12383 15 mobilization mobilization NN cord-005453-4057qib7 12383 16 . . . cord-005453-4057qib7 12384 1 Clinical clinical JJ cord-005453-4057qib7 12384 2 Trial Trial NNP cord-005453-4057qib7 12384 3 Registry Registry NNP cord-005453-4057qib7 12384 4 : : : cord-005453-4057qib7 12385 1 -Disclosure -disclosure UH cord-005453-4057qib7 12385 2 : : : cord-005453-4057qib7 12385 3 nothing nothing NN cord-005453-4057qib7 12385 4 to to TO cord-005453-4057qib7 12385 5 declare declare VB cord-005453-4057qib7 12385 6 Prognostic prognostic JJ cord-005453-4057qib7 12385 7 factors factor NNS cord-005453-4057qib7 12385 8 for for IN cord-005453-4057qib7 12385 9 overall overall JJ cord-005453-4057qib7 12385 10 survival survival NN cord-005453-4057qib7 12385 11 after after IN cord-005453-4057qib7 12385 12 allogeneic allogeneic JJ cord-005453-4057qib7 12385 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 12385 14 cell cell NN cord-005453-4057qib7 12385 15 transplantation transplantation NN cord-005453-4057qib7 12385 16 in in IN cord-005453-4057qib7 12385 17 multiple multiple JJ cord-005453-4057qib7 12385 18 myeloma myeloma NN cord-005453-4057qib7 12385 19 patients patient NNS cord-005453-4057qib7 12386 1 All all DT cord-005453-4057qib7 12386 2 factors factor NNS cord-005453-4057qib7 12386 3 with with IN cord-005453-4057qib7 12386 4 significant significant JJ cord-005453-4057qib7 12386 5 influence influence NN cord-005453-4057qib7 12386 6 on on IN cord-005453-4057qib7 12386 7 pts pts NN cord-005453-4057qib7 12386 8 survival survival NN cord-005453-4057qib7 12386 9 were be VBD cord-005453-4057qib7 12386 10 included include VBN cord-005453-4057qib7 12386 11 multivariate multivariate JJ cord-005453-4057qib7 12386 12 analysis analysis NN cord-005453-4057qib7 12386 13 ( ( -LRB- cord-005453-4057qib7 12386 14 Cox Cox NNP cord-005453-4057qib7 12386 15 regression regression NN cord-005453-4057qib7 12386 16 model model NN cord-005453-4057qib7 12386 17 ) ) -RRB- cord-005453-4057qib7 12386 18 but but CC cord-005453-4057qib7 12386 19 only only RB cord-005453-4057qib7 12386 20 re re NN cord-005453-4057qib7 12386 21 - - NN cord-005453-4057qib7 12386 22 admission admission NN cord-005453-4057qib7 12386 23 in in IN cord-005453-4057qib7 12386 24 the the DT cord-005453-4057qib7 12386 25 first first JJ cord-005453-4057qib7 12386 26 365 365 CD cord-005453-4057qib7 12386 27 days day NNS cord-005453-4057qib7 12386 28 demonstrated demonstrate VBD cord-005453-4057qib7 12386 29 impact impact NN cord-005453-4057qib7 12386 30 on on IN cord-005453-4057qib7 12386 31 OS OS NNP cord-005453-4057qib7 12386 32 ( ( -LRB- cord-005453-4057qib7 12386 33 HR HR NNP cord-005453-4057qib7 12386 34 4 4 CD cord-005453-4057qib7 12386 35 , , , cord-005453-4057qib7 12386 36 082 082 CD cord-005453-4057qib7 12386 37 ; ; : cord-005453-4057qib7 12386 38 p=0 p=0 NNP cord-005453-4057qib7 12386 39 , , , cord-005453-4057qib7 12386 40 005 005 CD cord-005453-4057qib7 12386 41 ) ) -RRB- cord-005453-4057qib7 12386 42 . . . cord-005453-4057qib7 12387 1 Conclusions conclusion NNS cord-005453-4057qib7 12387 2 : : : cord-005453-4057qib7 12388 1 We -PRON- PRP cord-005453-4057qib7 12388 2 analyzed analyze VBD cord-005453-4057qib7 12388 3 risk risk NN cord-005453-4057qib7 12388 4 factors factor NNS cord-005453-4057qib7 12388 5 for for IN cord-005453-4057qib7 12388 6 survival survival NN cord-005453-4057qib7 12388 7 in in IN cord-005453-4057qib7 12388 8 MM MM NNP cord-005453-4057qib7 12388 9 pts pts NNP cord-005453-4057qib7 12388 10 who who WP cord-005453-4057qib7 12388 11 received receive VBD cord-005453-4057qib7 12388 12 allo allo NN cord-005453-4057qib7 12388 13 - - HYPH cord-005453-4057qib7 12388 14 HCT hct NN cord-005453-4057qib7 12388 15 . . . cord-005453-4057qib7 12389 1 Our -PRON- PRP$ cord-005453-4057qib7 12389 2 study study NN cord-005453-4057qib7 12389 3 identified identify VBD cord-005453-4057qib7 12389 4 disease disease NN cord-005453-4057qib7 12389 5 - - HYPH cord-005453-4057qib7 12389 6 related relate VBN cord-005453-4057qib7 12389 7 risk risk NN cord-005453-4057qib7 12389 8 factors factor NNS cord-005453-4057qib7 12389 9 like like IN cord-005453-4057qib7 12389 10 ISS ISS NNP cord-005453-4057qib7 12389 11 and and CC cord-005453-4057qib7 12389 12 transplantationrelated transplantationrelate VBN cord-005453-4057qib7 12389 13 factors factor NNS cord-005453-4057qib7 12389 14 such such JJ cord-005453-4057qib7 12389 15 as as IN cord-005453-4057qib7 12389 16 HCT HCT NNP cord-005453-4057qib7 12389 17 - - HYPH cord-005453-4057qib7 12389 18 CI CI NNP cord-005453-4057qib7 12389 19 and and CC cord-005453-4057qib7 12389 20 PAM PAM NNP cord-005453-4057qib7 12389 21 , , , cord-005453-4057qib7 12389 22 hospital hospital NN cord-005453-4057qib7 12389 23 readmission readmission NN cord-005453-4057qib7 12389 24 , , , cord-005453-4057qib7 12389 25 days day NNS cord-005453-4057qib7 12389 26 of of IN cord-005453-4057qib7 12389 27 hospitalization hospitalization NN cord-005453-4057qib7 12389 28 and and CC cord-005453-4057qib7 12389 29 CMV CMV NNP cord-005453-4057qib7 12389 30 reactivation reactivation NN cord-005453-4057qib7 12389 31 that that WDT cord-005453-4057qib7 12389 32 were be VBD cord-005453-4057qib7 12389 33 associated associate VBN cord-005453-4057qib7 12389 34 with with IN cord-005453-4057qib7 12389 35 worse bad JJR cord-005453-4057qib7 12389 36 long long JJ cord-005453-4057qib7 12389 37 - - HYPH cord-005453-4057qib7 12389 38 term term NN cord-005453-4057qib7 12389 39 survival survival NN cord-005453-4057qib7 12389 40 . . . cord-005453-4057qib7 12390 1 In in IN cord-005453-4057qib7 12390 2 our -PRON- PRP$ cord-005453-4057qib7 12390 3 series series NN cord-005453-4057qib7 12390 4 , , , cord-005453-4057qib7 12390 5 the the DT cord-005453-4057qib7 12390 6 most most RBS cord-005453-4057qib7 12390 7 frequent frequent JJ cord-005453-4057qib7 12390 8 death death NN cord-005453-4057qib7 12390 9 and and CC cord-005453-4057qib7 12390 10 re re NN cord-005453-4057qib7 12390 11 - - NN cord-005453-4057qib7 12390 12 admission admission NN cord-005453-4057qib7 12390 13 cause cause NN cord-005453-4057qib7 12390 14 was be VBD cord-005453-4057qib7 12390 15 infection infection NN cord-005453-4057qib7 12390 16 , , , cord-005453-4057qib7 12390 17 so so IN cord-005453-4057qib7 12390 18 focusing focus VBG cord-005453-4057qib7 12390 19 the the DT cord-005453-4057qib7 12390 20 efforts effort NNS cord-005453-4057qib7 12390 21 in in IN cord-005453-4057qib7 12390 22 reduction reduction NN cord-005453-4057qib7 12390 23 of of IN cord-005453-4057qib7 12390 24 infection infection NN cord-005453-4057qib7 12390 25 could could MD cord-005453-4057qib7 12390 26 have have VB cord-005453-4057qib7 12390 27 a a DT cord-005453-4057qib7 12390 28 beneficial beneficial JJ cord-005453-4057qib7 12390 29 impact impact NN cord-005453-4057qib7 12390 30 on on IN cord-005453-4057qib7 12390 31 improvement improvement NN cord-005453-4057qib7 12390 32 of of IN cord-005453-4057qib7 12390 33 survival survival NN cord-005453-4057qib7 12390 34 in in IN cord-005453-4057qib7 12390 35 MM MM NNP cord-005453-4057qib7 12390 36 undergoing undergo VBG cord-005453-4057qib7 12390 37 allo allo NN cord-005453-4057qib7 12390 38 - - HYPH cord-005453-4057qib7 12390 39 HCT hct NN cord-005453-4057qib7 12390 40 . . . cord-005453-4057qib7 12391 1 [ [ -LRB- cord-005453-4057qib7 12391 2 [ [ -LRB- cord-005453-4057qib7 12391 3 P547 p547 CD cord-005453-4057qib7 12391 4 Image image NN cord-005453-4057qib7 12391 5 ] ] -RRB- cord-005453-4057qib7 12391 6 1 1 CD cord-005453-4057qib7 12391 7 . . . cord-005453-4057qib7 12392 1 Figure figure NN cord-005453-4057qib7 12392 2 1 1 CD cord-005453-4057qib7 12392 3 ] ] -RRB- cord-005453-4057qib7 12393 1 Disclosure disclosure NN cord-005453-4057qib7 12393 2 : : : cord-005453-4057qib7 12393 3 There there EX cord-005453-4057qib7 12393 4 is be VBZ cord-005453-4057qib7 12393 5 no no DT cord-005453-4057qib7 12393 6 disclosure disclosure NN cord-005453-4057qib7 12393 7 . . . cord-005453-4057qib7 12394 1 Novel novel NN cord-005453-4057qib7 12394 2 protocol protocol NN cord-005453-4057qib7 12394 3 for for IN cord-005453-4057qib7 12394 4 autologous autologous JJ cord-005453-4057qib7 12394 5 hsct hsct NN cord-005453-4057qib7 12394 6 in in IN cord-005453-4057qib7 12394 7 multiple multiple JJ cord-005453-4057qib7 12394 8 myeloma myeloma NN cord-005453-4057qib7 12394 9 : : : cord-005453-4057qib7 12394 10 Ambulatory ambulatory JJ cord-005453-4057qib7 12394 11 chemomobilization chemomobilization NN cord-005453-4057qib7 12394 12 and and CC cord-005453-4057qib7 12394 13 transplantation transplantation NN cord-005453-4057qib7 12394 14 of of IN cord-005453-4057qib7 12394 15 fresh fresh JJ cord-005453-4057qib7 12394 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 12394 17 stem stem NN cord-005453-4057qib7 12394 18 cells cell NNS cord-005453-4057qib7 12394 19 with with IN cord-005453-4057qib7 12394 20 backup backup JJ cord-005453-4057qib7 12394 21 storage storage NN cord-005453-4057qib7 12394 22 Background background NN cord-005453-4057qib7 12394 23 : : : cord-005453-4057qib7 12394 24 Autologous autologous JJ cord-005453-4057qib7 12394 25 hematopoietic hematopoietic JJ cord-005453-4057qib7 12394 26 stem stem NN cord-005453-4057qib7 12394 27 cell cell NN cord-005453-4057qib7 12394 28 transplantation transplantation NN cord-005453-4057qib7 12394 29 ( ( -LRB- cord-005453-4057qib7 12394 30 AHSCT AHSCT NNP cord-005453-4057qib7 12394 31 ) ) -RRB- cord-005453-4057qib7 12395 1 after after IN cord-005453-4057qib7 12395 2 melphalan melphalan NNP cord-005453-4057qib7 12395 3 conditioning conditioning NNP cord-005453-4057qib7 12395 4 is be VBZ cord-005453-4057qib7 12395 5 still still RB cord-005453-4057qib7 12395 6 a a DT cord-005453-4057qib7 12395 7 part part NN cord-005453-4057qib7 12395 8 of of IN cord-005453-4057qib7 12395 9 standard standard JJ cord-005453-4057qib7 12395 10 treatment treatment NN cord-005453-4057qib7 12395 11 of of IN cord-005453-4057qib7 12395 12 multiple multiple JJ cord-005453-4057qib7 12395 13 myeloma myeloma NN cord-005453-4057qib7 12395 14 patients patient NNS cord-005453-4057qib7 12395 15 . . . cord-005453-4057qib7 12396 1 Traditional traditional JJ cord-005453-4057qib7 12396 2 transplantation transplantation NN cord-005453-4057qib7 12396 3 of of IN cord-005453-4057qib7 12396 4 frozen frozen JJ cord-005453-4057qib7 12396 5 stem stem NN cord-005453-4057qib7 12396 6 cells cell NNS cord-005453-4057qib7 12396 7 poses pose VBZ cord-005453-4057qib7 12396 8 additional additional JJ cord-005453-4057qib7 12396 9 risk risk NN cord-005453-4057qib7 12396 10 for for IN cord-005453-4057qib7 12396 11 the the DT cord-005453-4057qib7 12396 12 patients patient NNS cord-005453-4057qib7 12396 13 connected connect VBN cord-005453-4057qib7 12396 14 with with IN cord-005453-4057qib7 12396 15 DMSO DMSO NNP cord-005453-4057qib7 12396 16 and and CC cord-005453-4057qib7 12396 17 central central JJ cord-005453-4057qib7 12396 18 venous venous JJ cord-005453-4057qib7 12396 19 catheter catheter NN cord-005453-4057qib7 12396 20 . . . cord-005453-4057qib7 12397 1 The the DT cord-005453-4057qib7 12397 2 transplantation transplantation NN cord-005453-4057qib7 12397 3 of of IN cord-005453-4057qib7 12397 4 fresh fresh JJ cord-005453-4057qib7 12397 5 cells cell NNS cord-005453-4057qib7 12397 6 is be VBZ cord-005453-4057qib7 12397 7 an an DT cord-005453-4057qib7 12397 8 option option NN cord-005453-4057qib7 12397 9 -however -however TO cord-005453-4057qib7 12397 10 , , , cord-005453-4057qib7 12397 11 most most JJS cord-005453-4057qib7 12397 12 mobilization mobilization NN cord-005453-4057qib7 12397 13 protocols protocol NNS cord-005453-4057qib7 12397 14 are be VBP cord-005453-4057qib7 12397 15 either either RB cord-005453-4057qib7 12397 16 low low RB cord-005453-4057qib7 12397 17 - - HYPH cord-005453-4057qib7 12397 18 efficient efficient JJ cord-005453-4057qib7 12397 19 ( ( -LRB- cord-005453-4057qib7 12397 20 G G NNP cord-005453-4057qib7 12397 21 - - HYPH cord-005453-4057qib7 12397 22 CSF CSF NNP cord-005453-4057qib7 12397 23 ) ) -RRB- cord-005453-4057qib7 12397 24 , , , cord-005453-4057qib7 12397 25 expensive expensive JJ cord-005453-4057qib7 12397 26 ( ( -LRB- cord-005453-4057qib7 12397 27 G G NNP cord-005453-4057qib7 12397 28 - - HYPH cord-005453-4057qib7 12397 29 CSF csf NN cord-005453-4057qib7 12397 30 + + CC cord-005453-4057qib7 12397 31 plerixafor plerixafor NN cord-005453-4057qib7 12397 32 ) ) -RRB- cord-005453-4057qib7 12397 33 or or CC cord-005453-4057qib7 12397 34 toxic toxic JJ cord-005453-4057qib7 12397 35 ( ( -LRB- cord-005453-4057qib7 12397 36 standard standard JJ cord-005453-4057qib7 12397 37 dose dose JJ cord-005453-4057qib7 12397 38 chemomobilization chemomobilization NN cord-005453-4057qib7 12397 39 ) ) -RRB- cord-005453-4057qib7 12397 40 to to TO cord-005453-4057qib7 12397 41 directly directly RB cord-005453-4057qib7 12397 42 proceed proceed VB cord-005453-4057qib7 12397 43 to to IN cord-005453-4057qib7 12397 44 transplantation transplantation NN cord-005453-4057qib7 12397 45 in in IN cord-005453-4057qib7 12397 46 this this DT cord-005453-4057qib7 12397 47 fragile fragile JJ cord-005453-4057qib7 12397 48 group group NN cord-005453-4057qib7 12397 49 of of IN cord-005453-4057qib7 12397 50 patients patient NNS cord-005453-4057qib7 12397 51 . . . cord-005453-4057qib7 12398 1 We -PRON- PRP cord-005453-4057qib7 12398 2 describe describe VBP cord-005453-4057qib7 12398 3 here here RB cord-005453-4057qib7 12398 4 the the DT cord-005453-4057qib7 12398 5 novel novel JJ cord-005453-4057qib7 12398 6 combination combination NN cord-005453-4057qib7 12398 7 of of IN cord-005453-4057qib7 12398 8 ambulatory ambulatory JJ cord-005453-4057qib7 12398 9 mobilization mobilization NN cord-005453-4057qib7 12398 10 with with IN cord-005453-4057qib7 12398 11 very very RB cord-005453-4057qib7 12398 12 low low JJ cord-005453-4057qib7 12398 13 doses dose NNS cord-005453-4057qib7 12398 14 of of IN cord-005453-4057qib7 12398 15 Ara Ara NNP cord-005453-4057qib7 12398 16 - - HYPH cord-005453-4057qib7 12398 17 C C NNP cord-005453-4057qib7 12398 18 and and CC cord-005453-4057qib7 12398 19 G G NNP cord-005453-4057qib7 12398 20 - - HYPH cord-005453-4057qib7 12398 21 CSF csf NN cord-005453-4057qib7 12398 22 connected connect VBN cord-005453-4057qib7 12398 23 with with IN cord-005453-4057qib7 12398 24 direct direct JJ cord-005453-4057qib7 12398 25 AHSCT AHSCT NNP cord-005453-4057qib7 12398 26 with with IN cord-005453-4057qib7 12398 27 fresh fresh JJ cord-005453-4057qib7 12398 28 cells cell NNS cord-005453-4057qib7 12398 29 . . . cord-005453-4057qib7 12399 1 Methods method NNS cord-005453-4057qib7 12399 2 : : : cord-005453-4057qib7 12400 1 The the DT cord-005453-4057qib7 12400 2 prospectively prospectively RB cord-005453-4057qib7 12400 3 collected collect VBN cord-005453-4057qib7 12400 4 database database NN cord-005453-4057qib7 12400 5 of of IN cord-005453-4057qib7 12400 6 patients patient NNS cord-005453-4057qib7 12400 7 after after IN cord-005453-4057qib7 12400 8 AHSCT AHSCT NNP cord-005453-4057qib7 12400 9 was be VBD cord-005453-4057qib7 12400 10 searched search VBN cord-005453-4057qib7 12400 11 for for IN cord-005453-4057qib7 12400 12 patients patient NNS cord-005453-4057qib7 12400 13 who who WP cord-005453-4057qib7 12400 14 underwent undergo VBD cord-005453-4057qib7 12400 15 AHSCT AHSCT NNP cord-005453-4057qib7 12400 16 after after IN cord-005453-4057qib7 12400 17 chemomobilization chemomobilization NN cord-005453-4057qib7 12400 18 with with IN cord-005453-4057qib7 12400 19 Ara Ara NNP cord-005453-4057qib7 12400 20 - - HYPH cord-005453-4057qib7 12400 21 C C NNP cord-005453-4057qib7 12400 22 and and CC cord-005453-4057qib7 12400 23 transplantation transplantation NN cord-005453-4057qib7 12400 24 with with IN cord-005453-4057qib7 12400 25 fresh fresh JJ cord-005453-4057qib7 12400 26 cells cell NNS cord-005453-4057qib7 12400 27 ( ( -LRB- cord-005453-4057qib7 12400 28 FC FC NNP cord-005453-4057qib7 12400 29 ) ) -RRB- cord-005453-4057qib7 12400 30 and and CC cord-005453-4057qib7 12400 31 compared compare VBN cord-005453-4057qib7 12400 32 with with IN cord-005453-4057qib7 12400 33 control control NN cord-005453-4057qib7 12400 34 group group NN cord-005453-4057qib7 12400 35 of of IN cord-005453-4057qib7 12400 36 consecutive consecutive JJ cord-005453-4057qib7 12400 37 patients patient NNS cord-005453-4057qib7 12400 38 transplanted transplant VBN cord-005453-4057qib7 12400 39 with with IN cord-005453-4057qib7 12400 40 standard standard JJ cord-005453-4057qib7 12400 41 protocol protocol NN cord-005453-4057qib7 12400 42 ( ( -LRB- cord-005453-4057qib7 12400 43 SP SP NNP cord-005453-4057qib7 12400 44 ) ) -RRB- cord-005453-4057qib7 12400 45 ( ( -LRB- cord-005453-4057qib7 12400 46 transplantation transplantation NN cord-005453-4057qib7 12400 47 with with IN cord-005453-4057qib7 12400 48 frozen frozen JJ cord-005453-4057qib7 12400 49 cells cell NNS cord-005453-4057qib7 12400 50 ) ) -RRB- cord-005453-4057qib7 12400 51 between between IN cord-005453-4057qib7 12400 52 July July NNP cord-005453-4057qib7 12400 53 2016 2016 CD cord-005453-4057qib7 12400 54 and and CC cord-005453-4057qib7 12400 55 October October NNP cord-005453-4057qib7 12400 56 2018 2018 CD cord-005453-4057qib7 12400 57 . . . cord-005453-4057qib7 12401 1 Protocol protocol NN cord-005453-4057qib7 12401 2 of of IN cord-005453-4057qib7 12401 3 ambulatory ambulatory JJ cord-005453-4057qib7 12401 4 mobilization mobilization NN cord-005453-4057qib7 12401 5 was be VBD cord-005453-4057qib7 12401 6 : : : cord-005453-4057qib7 12401 7 400mg 400mg NNP cord-005453-4057qib7 12401 8 / / SYM cord-005453-4057qib7 12401 9 m² m² NNP cord-005453-4057qib7 12401 10 of of IN cord-005453-4057qib7 12401 11 AraC AraC NNP cord-005453-4057qib7 12401 12 on on IN cord-005453-4057qib7 12401 13 days day NNS cord-005453-4057qib7 12401 14 +1 +1 NFP cord-005453-4057qib7 12401 15 and and CC cord-005453-4057qib7 12401 16 +2 +2 NN cord-005453-4057qib7 12401 17 and and CC cord-005453-4057qib7 12401 18 G G NNP cord-005453-4057qib7 12401 19 - - HYPH cord-005453-4057qib7 12401 20 CSF CSF NNP cord-005453-4057qib7 12401 21 at at IN cord-005453-4057qib7 12401 22 the the DT cord-005453-4057qib7 12401 23 dose dose NN cord-005453-4057qib7 12401 24 5 5 CD cord-005453-4057qib7 12401 25 μg μg NNP cord-005453-4057qib7 12401 26 / / SYM cord-005453-4057qib7 12401 27 kg kg NNP cord-005453-4057qib7 12401 28 / / SYM cord-005453-4057qib7 12401 29 day day NN cord-005453-4057qib7 12401 30 from from IN cord-005453-4057qib7 12401 31 day day NN cord-005453-4057qib7 12401 32 +5 +5 NFP cord-005453-4057qib7 12401 33 and and CC cord-005453-4057qib7 12401 34 escalated escalate VBD cord-005453-4057qib7 12401 35 to to IN cord-005453-4057qib7 12401 36 10 10 CD cord-005453-4057qib7 12401 37 μg/ μg/ NN cord-005453-4057qib7 12402 1 kg kg NNP cord-005453-4057qib7 12402 2 / / SYM cord-005453-4057qib7 12402 3 day day NN cord-005453-4057qib7 12402 4 split split VBD cord-005453-4057qib7 12402 5 into into IN cord-005453-4057qib7 12402 6 two two CD cord-005453-4057qib7 12402 7 doses dose NNS cord-005453-4057qib7 12402 8 +10 +10 CD cord-005453-4057qib7 12402 9 to to IN cord-005453-4057qib7 12402 10 +13 +13 NN cord-005453-4057qib7 12403 1 , , , cord-005453-4057qib7 12403 2 apheresis apheresis NN cord-005453-4057qib7 12403 3 started start VBD cord-005453-4057qib7 12403 4 on on IN cord-005453-4057qib7 12403 5 day day NN cord-005453-4057qib7 12403 6 +14 +14 CD cord-005453-4057qib7 12403 7 ( ( -LRB- cord-005453-4057qib7 12403 8 or or CC cord-005453-4057qib7 12403 9 later later RB cord-005453-4057qib7 12403 10 ) ) -RRB- cord-005453-4057qib7 12403 11 and and CC cord-005453-4057qib7 12403 12 finished finish VBD cord-005453-4057qib7 12403 13 when when WRB cord-005453-4057qib7 12403 14 at at RB cord-005453-4057qib7 12403 15 least least JJS cord-005453-4057qib7 12403 16 7.5 7.5 CD cord-005453-4057qib7 12403 17 x x SYM cord-005453-4057qib7 12403 18 10e6 10e6 CD cord-005453-4057qib7 12403 19 CD34 CD34 NNP cord-005453-4057qib7 12403 20 + + CC cord-005453-4057qib7 12403 21 positive positive JJ cord-005453-4057qib7 12403 22 cells cell NNS cord-005453-4057qib7 12403 23 were be VBD cord-005453-4057qib7 12403 24 collected collect VBN cord-005453-4057qib7 12403 25 . . . cord-005453-4057qib7 12404 1 The the DT cord-005453-4057qib7 12404 2 collected collect VBN cord-005453-4057qib7 12404 3 cells cell NNS cord-005453-4057qib7 12404 4 were be VBD cord-005453-4057qib7 12404 5 split split VBN cord-005453-4057qib7 12404 6 in in IN cord-005453-4057qib7 12404 7 three three CD cord-005453-4057qib7 12404 8 equal equal JJ cord-005453-4057qib7 12404 9 parts:1 parts:1 NN cord-005453-4057qib7 12404 10 ) ) -RRB- cord-005453-4057qib7 12404 11 for for IN cord-005453-4057qib7 12404 12 use use NN cord-005453-4057qib7 12404 13 as as IN cord-005453-4057qib7 12404 14 fresh fresh JJ cord-005453-4057qib7 12404 15 transplant transplant NN cord-005453-4057qib7 12404 16 2 2 CD cord-005453-4057qib7 12404 17 ) ) -RRB- cord-005453-4057qib7 12404 18 frozen freeze VBN cord-005453-4057qib7 12404 19 for for IN cord-005453-4057qib7 12404 20 possible possible JJ cord-005453-4057qib7 12404 21 2 2 CD cord-005453-4057qib7 12404 22 nd nd NNP cord-005453-4057qib7 12404 23 transplant transplant NN cord-005453-4057qib7 12404 24 3 3 CD cord-005453-4057qib7 12404 25 ) ) -RRB- cord-005453-4057qib7 12404 26 frozen freeze VBN cord-005453-4057qib7 12404 27 as as IN cord-005453-4057qib7 12404 28 backup backup NN cord-005453-4057qib7 12404 29 . . . cord-005453-4057qib7 12405 1 Results result NNS cord-005453-4057qib7 12405 2 : : : cord-005453-4057qib7 12406 1 There there EX cord-005453-4057qib7 12406 2 were be VBD cord-005453-4057qib7 12406 3 48 48 CD cord-005453-4057qib7 12406 4 transplantations transplantation NNS cord-005453-4057qib7 12406 5 with with IN cord-005453-4057qib7 12406 6 fresh fresh JJ cord-005453-4057qib7 12406 7 cells cell NNS cord-005453-4057qib7 12406 8 and and CC cord-005453-4057qib7 12406 9 49 49 CD cord-005453-4057qib7 12406 10 transplantations transplantation NNS cord-005453-4057qib7 12406 11 with with IN cord-005453-4057qib7 12406 12 frozen frozen JJ cord-005453-4057qib7 12406 13 cells cell NNS cord-005453-4057qib7 12406 14 compared compare VBN cord-005453-4057qib7 12406 15 . . . cord-005453-4057qib7 12407 1 Both both DT cord-005453-4057qib7 12407 2 groups group NNS cord-005453-4057qib7 12407 3 had have VBD cord-005453-4057qib7 12407 4 same same JJ cord-005453-4057qib7 12407 5 mobilization mobilization NN cord-005453-4057qib7 12407 6 protocol protocol NN cord-005453-4057qib7 12407 7 -ambulatory -ambulatory . cord-005453-4057qib7 12408 1 low low JJ cord-005453-4057qib7 12408 2 dose dose NN cord-005453-4057qib7 12408 3 ARA ARA NNP cord-005453-4057qib7 12408 4 - - HYPH cord-005453-4057qib7 12408 5 C. C. NNP cord-005453-4057qib7 12409 1 The the DT cord-005453-4057qib7 12409 2 median median JJ cord-005453-4057qib7 12409 3 age age NN cord-005453-4057qib7 12409 4 and and CC cord-005453-4057qib7 12409 5 number number NN cord-005453-4057qib7 12409 6 of of IN cord-005453-4057qib7 12409 7 transplanted transplanted JJ cord-005453-4057qib7 12409 8 cells cell NNS cord-005453-4057qib7 12409 9 was be VBD cord-005453-4057qib7 12409 10 similar similar JJ cord-005453-4057qib7 12409 11 in in IN cord-005453-4057qib7 12409 12 both both DT cord-005453-4057qib7 12409 13 groups group NNS cord-005453-4057qib7 12410 1 ( ( -LRB- cord-005453-4057qib7 12410 2 56 56 CD cord-005453-4057qib7 12410 3 vs vs IN cord-005453-4057qib7 12410 4 57 57 CD cord-005453-4057qib7 12410 5 , , , cord-005453-4057qib7 12410 6 p=0.99 p=0.99 NN cord-005453-4057qib7 12410 7 ; ; : cord-005453-4057qib7 12410 8 5.2 5.2 CD cord-005453-4057qib7 12410 9 vs vs IN cord-005453-4057qib7 12410 10 5.3 5.3 CD cord-005453-4057qib7 12410 11 CD34+/KG CD34+/KG NNP cord-005453-4057qib7 12410 12 , , , cord-005453-4057qib7 12410 13 p=0.97 p=0.97 NNP cord-005453-4057qib7 12410 14 Conclusions Conclusions NNPS cord-005453-4057qib7 12410 15 : : : cord-005453-4057qib7 12411 1 We -PRON- PRP cord-005453-4057qib7 12411 2 present present VBP cord-005453-4057qib7 12411 3 novel novel JJ cord-005453-4057qib7 12411 4 approach approach NN cord-005453-4057qib7 12411 5 that that WDT cord-005453-4057qib7 12411 6 allows allow VBZ cord-005453-4057qib7 12411 7 direct direct JJ cord-005453-4057qib7 12411 8 AHSCT AHSCT NNP cord-005453-4057qib7 12411 9 after after IN cord-005453-4057qib7 12411 10 chemo chemo NN cord-005453-4057qib7 12411 11 mobilization mobilization NN cord-005453-4057qib7 12411 12 in in IN cord-005453-4057qib7 12411 13 all all DT cord-005453-4057qib7 12411 14 patients patient NNS cord-005453-4057qib7 12411 15 who who WP cord-005453-4057qib7 12411 16 are be VBP cord-005453-4057qib7 12411 17 treated treat VBN cord-005453-4057qib7 12411 18 with with IN cord-005453-4057qib7 12411 19 melphalan melphalan NNP cord-005453-4057qib7 12411 20 . . . cord-005453-4057qib7 12412 1 We -PRON- PRP cord-005453-4057qib7 12412 2 show show VBP cord-005453-4057qib7 12412 3 that that IN cord-005453-4057qib7 12412 4 it -PRON- PRP cord-005453-4057qib7 12412 5 is be VBZ cord-005453-4057qib7 12412 6 not not RB cord-005453-4057qib7 12412 7 only only RB cord-005453-4057qib7 12412 8 feasible feasible JJ cord-005453-4057qib7 12412 9 to to TO cord-005453-4057qib7 12412 10 do do VB cord-005453-4057qib7 12412 11 AHSCT AHSCT NNP cord-005453-4057qib7 12412 12 directly directly RB cord-005453-4057qib7 12412 13 after after IN cord-005453-4057qib7 12412 14 chemomobilization chemomobilization NN cord-005453-4057qib7 12412 15 but but CC cord-005453-4057qib7 12412 16 also also RB cord-005453-4057qib7 12412 17 the the DT cord-005453-4057qib7 12412 18 results result NNS cord-005453-4057qib7 12412 19 may may MD cord-005453-4057qib7 12412 20 favour favour VB cord-005453-4057qib7 12412 21 this this DT cord-005453-4057qib7 12412 22 approach approach NN cord-005453-4057qib7 12412 23 when when WRB cord-005453-4057qib7 12412 24 compared compare VBN cord-005453-4057qib7 12412 25 with with IN cord-005453-4057qib7 12412 26 current current JJ cord-005453-4057qib7 12412 27 standard standard NN cord-005453-4057qib7 12412 28 . . . cord-005453-4057qib7 12413 1 Disclosure disclosure NN cord-005453-4057qib7 12413 2 : : : cord-005453-4057qib7 12413 3 Nothing nothing NN cord-005453-4057qib7 12413 4 to to TO cord-005453-4057qib7 12413 5 declare declare VB cord-005453-4057qib7 12413 6 Background background NN cord-005453-4057qib7 12413 7 : : : cord-005453-4057qib7 12414 1 High high JJ cord-005453-4057qib7 12414 2 dose dose NN cord-005453-4057qib7 12414 3 chemotherapy chemotherapy NN cord-005453-4057qib7 12414 4 followed follow VBN cord-005453-4057qib7 12414 5 by by IN cord-005453-4057qib7 12414 6 autologous autologous JJ cord-005453-4057qib7 12414 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 12414 8 cell cell NN cord-005453-4057qib7 12414 9 transplantation transplantation NN cord-005453-4057qib7 12414 10 ( ( -LRB- cord-005453-4057qib7 12414 11 HSCT HSCT NNP cord-005453-4057qib7 12414 12 ) ) -RRB- cord-005453-4057qib7 12414 13 is be VBZ cord-005453-4057qib7 12414 14 considered consider VBN cord-005453-4057qib7 12414 15 , , , cord-005453-4057qib7 12414 16 since since IN cord-005453-4057qib7 12414 17 the the DT cord-005453-4057qib7 12414 18 nineties ninety NNS cord-005453-4057qib7 12414 19 , , , cord-005453-4057qib7 12414 20 the the DT cord-005453-4057qib7 12414 21 standard standard NN cord-005453-4057qib7 12414 22 of of IN cord-005453-4057qib7 12414 23 care care NN cord-005453-4057qib7 12414 24 for for IN cord-005453-4057qib7 12414 25 patients patient NNS cord-005453-4057qib7 12414 26 aged age VBN cord-005453-4057qib7 12414 27 less less JJR cord-005453-4057qib7 12414 28 than than IN cord-005453-4057qib7 12414 29 70 70 CD cord-005453-4057qib7 12414 30 - - SYM cord-005453-4057qib7 12414 31 75 75 CD cord-005453-4057qib7 12414 32 years year NNS cord-005453-4057qib7 12414 33 old old JJ cord-005453-4057qib7 12414 34 with with IN cord-005453-4057qib7 12414 35 newly newly RB cord-005453-4057qib7 12414 36 diagnosed diagnose VBN cord-005453-4057qib7 12414 37 multiple multiple JJ cord-005453-4057qib7 12414 38 myeloma myeloma NN cord-005453-4057qib7 12414 39 ( ( -LRB- cord-005453-4057qib7 12414 40 MM MM NNP cord-005453-4057qib7 12414 41 ) ) -RRB- cord-005453-4057qib7 12414 42 . . . cord-005453-4057qib7 12415 1 However however RB cord-005453-4057qib7 12415 2 , , , cord-005453-4057qib7 12415 3 the the DT cord-005453-4057qib7 12415 4 optimal optimal JJ cord-005453-4057qib7 12415 5 induction induction NN cord-005453-4057qib7 12415 6 treatment treatment NN cord-005453-4057qib7 12415 7 prior prior RB cord-005453-4057qib7 12415 8 to to IN cord-005453-4057qib7 12415 9 HSCT HSCT NNP cord-005453-4057qib7 12415 10 to to TO cord-005453-4057qib7 12415 11 reduce reduce VB cord-005453-4057qib7 12415 12 the the DT cord-005453-4057qib7 12415 13 tumor tumor NN cord-005453-4057qib7 12415 14 burden burden NN cord-005453-4057qib7 12415 15 has have VBZ cord-005453-4057qib7 12415 16 changed change VBN cord-005453-4057qib7 12415 17 during during IN cord-005453-4057qib7 12415 18 the the DT cord-005453-4057qib7 12415 19 last last JJ cord-005453-4057qib7 12415 20 few few JJ cord-005453-4057qib7 12415 21 years year NNS cord-005453-4057qib7 12415 22 . . . cord-005453-4057qib7 12416 1 Improved improve VBN cord-005453-4057qib7 12416 2 regimens regimen NNS cord-005453-4057qib7 12416 3 have have VBP cord-005453-4057qib7 12416 4 shown show VBN cord-005453-4057qib7 12416 5 to to TO cord-005453-4057qib7 12416 6 be be VB cord-005453-4057qib7 12416 7 able able JJ cord-005453-4057qib7 12416 8 to to TO cord-005453-4057qib7 12416 9 increase increase VB cord-005453-4057qib7 12416 10 the the DT cord-005453-4057qib7 12416 11 quality quality NN cord-005453-4057qib7 12416 12 of of IN cord-005453-4057qib7 12416 13 the the DT cord-005453-4057qib7 12416 14 pre pre JJ cord-005453-4057qib7 12416 15 - - JJ cord-005453-4057qib7 12416 16 HSCT hsct JJ cord-005453-4057qib7 12416 17 response response NN cord-005453-4057qib7 12416 18 , , , cord-005453-4057qib7 12416 19 which which WDT cord-005453-4057qib7 12416 20 might may MD cord-005453-4057qib7 12416 21 subsequently subsequently RB cord-005453-4057qib7 12416 22 impact impact VB cord-005453-4057qib7 12416 23 on on IN cord-005453-4057qib7 12416 24 the the DT cord-005453-4057qib7 12416 25 post post JJ cord-005453-4057qib7 12416 26 - - JJ cord-005453-4057qib7 12416 27 HSCT hsct JJ cord-005453-4057qib7 12416 28 response response NN cord-005453-4057qib7 12416 29 , , , cord-005453-4057qib7 12416 30 which which WDT cord-005453-4057qib7 12416 31 has have VBZ cord-005453-4057qib7 12416 32 been be VBN cord-005453-4057qib7 12416 33 proved prove VBN cord-005453-4057qib7 12416 34 to to TO cord-005453-4057qib7 12416 35 be be VB cord-005453-4057qib7 12416 36 associated associate VBN cord-005453-4057qib7 12416 37 with with IN cord-005453-4057qib7 12416 38 a a DT cord-005453-4057qib7 12416 39 longer long JJR cord-005453-4057qib7 12416 40 PFS PFS NNP cord-005453-4057qib7 12416 41 . . . cord-005453-4057qib7 12417 1 We -PRON- PRP cord-005453-4057qib7 12417 2 recently recently RB cord-005453-4057qib7 12417 3 changed change VBD cord-005453-4057qib7 12417 4 the the DT cord-005453-4057qib7 12417 5 induction induction NN cord-005453-4057qib7 12417 6 therapy therapy NN cord-005453-4057qib7 12417 7 for for IN cord-005453-4057qib7 12417 8 pts pts NN cord-005453-4057qib7 12417 9 candidates candidate NNS cord-005453-4057qib7 12417 10 to to IN cord-005453-4057qib7 12417 11 HSCT HSCT NNP cord-005453-4057qib7 12417 12 . . . cord-005453-4057qib7 12418 1 In in IN cord-005453-4057qib7 12418 2 this this DT cord-005453-4057qib7 12418 3 analysis analysis NN cord-005453-4057qib7 12418 4 , , , cord-005453-4057qib7 12418 5 we -PRON- PRP cord-005453-4057qib7 12418 6 aimed aim VBD cord-005453-4057qib7 12418 7 to to TO cord-005453-4057qib7 12418 8 check check VB cord-005453-4057qib7 12418 9 if if IN cord-005453-4057qib7 12418 10 newer new JJR cord-005453-4057qib7 12418 11 regimens regimen NNS cord-005453-4057qib7 12418 12 impacted impact VBN cord-005453-4057qib7 12418 13 on on IN cord-005453-4057qib7 12418 14 pretransplant pretransplant JJ cord-005453-4057qib7 12418 15 responses response NNS cord-005453-4057qib7 12418 16 , , , cord-005453-4057qib7 12418 17 and and CC cord-005453-4057qib7 12418 18 how how WRB cord-005453-4057qib7 12418 19 auto auto NN cord-005453-4057qib7 12418 20 - - HYPH cord-005453-4057qib7 12418 21 HSCT HSCT NNP cord-005453-4057qib7 12418 22 changed change VBD cord-005453-4057qib7 12418 23 the the DT cord-005453-4057qib7 12418 24 pre pre JJ cord-005453-4057qib7 12418 25 - - JJ cord-005453-4057qib7 12418 26 HSCT hsct JJ cord-005453-4057qib7 12418 27 status status NN cord-005453-4057qib7 12418 28 . . . cord-005453-4057qib7 12419 1 Methods method NNS cord-005453-4057qib7 12419 2 : : : cord-005453-4057qib7 12419 3 All all PDT cord-005453-4057qib7 12419 4 the the DT cord-005453-4057qib7 12419 5 117 117 CD cord-005453-4057qib7 12419 6 auto auto NN cord-005453-4057qib7 12419 7 - - HYPH cord-005453-4057qib7 12419 8 HSCT HSCT NNP cord-005453-4057qib7 12419 9 for for IN cord-005453-4057qib7 12419 10 99 99 CD cord-005453-4057qib7 12419 11 MM MM NNP cord-005453-4057qib7 12419 12 patients patient NNS cord-005453-4057qib7 12419 13 performed perform VBN cord-005453-4057qib7 12419 14 in in IN cord-005453-4057qib7 12419 15 our -PRON- PRP$ cord-005453-4057qib7 12419 16 center center NN cord-005453-4057qib7 12419 17 from from IN cord-005453-4057qib7 12419 18 January January NNP cord-005453-4057qib7 12419 19 2014 2014 CD cord-005453-4057qib7 12419 20 through through IN cord-005453-4057qib7 12419 21 August August NNP cord-005453-4057qib7 12419 22 2018 2018 CD cord-005453-4057qib7 12419 23 were be VBD cord-005453-4057qib7 12419 24 included include VBN cord-005453-4057qib7 12419 25 in in IN cord-005453-4057qib7 12419 26 the the DT cord-005453-4057qib7 12419 27 analysis analysis NN cord-005453-4057qib7 12419 28 . . . cord-005453-4057qib7 12420 1 Median median JJ cord-005453-4057qib7 12420 2 age age NN cord-005453-4057qib7 12420 3 was be VBD cord-005453-4057qib7 12420 4 60 60 CD cord-005453-4057qib7 12420 5 years year NNS cord-005453-4057qib7 12421 1 ( ( -LRB- cord-005453-4057qib7 12421 2 range range NN cord-005453-4057qib7 12421 3 : : : cord-005453-4057qib7 12421 4 38 38 CD cord-005453-4057qib7 12421 5 - - SYM cord-005453-4057qib7 12421 6 76 76 CD cord-005453-4057qib7 12421 7 ) ) -RRB- cord-005453-4057qib7 12421 8 . . . cord-005453-4057qib7 12422 1 54 54 CD cord-005453-4057qib7 12422 2 pts pt NNS cord-005453-4057qib7 12422 3 were be VBD cord-005453-4057qib7 12422 4 male male JJ cord-005453-4057qib7 12422 5 and and CC cord-005453-4057qib7 12422 6 45 45 CD cord-005453-4057qib7 12422 7 were be VBD cord-005453-4057qib7 12422 8 female female JJ cord-005453-4057qib7 12422 9 . . . cord-005453-4057qib7 12423 1 Durie Durie NNP cord-005453-4057qib7 12423 2 - - HYPH cord-005453-4057qib7 12423 3 Salmon Salmon NNP cord-005453-4057qib7 12423 4 stage stage NN cord-005453-4057qib7 12423 5 was be VBD cord-005453-4057qib7 12423 6 distributed distribute VBN cord-005453-4057qib7 12423 7 as as IN cord-005453-4057qib7 12423 8 follows follow VBZ cord-005453-4057qib7 12423 9 : : : cord-005453-4057qib7 12423 10 I -PRON- PRP cord-005453-4057qib7 12423 11 ( ( -LRB- cord-005453-4057qib7 12423 12 9.4 9.4 CD cord-005453-4057qib7 12423 13 % % NN cord-005453-4057qib7 12423 14 ) ) -RRB- cord-005453-4057qib7 12423 15 , , , cord-005453-4057qib7 12423 16 II II NNP cord-005453-4057qib7 12423 17 ( ( -LRB- cord-005453-4057qib7 12423 18 37.6 37.6 CD cord-005453-4057qib7 12423 19 % % NN cord-005453-4057qib7 12423 20 ) ) -RRB- cord-005453-4057qib7 12423 21 and and CC cord-005453-4057qib7 12423 22 III III NNP cord-005453-4057qib7 12423 23 ( ( -LRB- cord-005453-4057qib7 12423 24 53 53 CD cord-005453-4057qib7 12423 25 % % NN cord-005453-4057qib7 12423 26 ) ) -RRB- cord-005453-4057qib7 12423 27 ; ; : cord-005453-4057qib7 12423 28 13 13 CD cord-005453-4057qib7 12423 29 % % NN cord-005453-4057qib7 12423 30 had have VBD cord-005453-4057qib7 12423 31 creatinine creatinine NN cord-005453-4057qib7 12424 1 > > XX cord-005453-4057qib7 12425 1 2 2 CD cord-005453-4057qib7 12425 2 mg mg NNP cord-005453-4057qib7 12425 3 / / SYM cord-005453-4057qib7 12425 4 dL. dl. NN cord-005453-4057qib7 12425 5 ISS ISS NNP cord-005453-4057qib7 12425 6 was be VBD cord-005453-4057qib7 12425 7 : : : cord-005453-4057qib7 12425 8 1 1 CD cord-005453-4057qib7 12425 9 ( ( -LRB- cord-005453-4057qib7 12425 10 41 41 CD cord-005453-4057qib7 12425 11 % % NN cord-005453-4057qib7 12425 12 ) ) -RRB- cord-005453-4057qib7 12425 13 , , , cord-005453-4057qib7 12425 14 2 2 CD cord-005453-4057qib7 12425 15 ( ( -LRB- cord-005453-4057qib7 12425 16 28.2 28.2 CD cord-005453-4057qib7 12425 17 % % NN cord-005453-4057qib7 12425 18 ) ) -RRB- cord-005453-4057qib7 12425 19 , , , cord-005453-4057qib7 12425 20 and and CC cord-005453-4057qib7 12425 21 3 3 CD cord-005453-4057qib7 12425 22 ( ( -LRB- cord-005453-4057qib7 12425 23 30.8 30.8 CD cord-005453-4057qib7 12425 24 % % NN cord-005453-4057qib7 12425 25 ) ) -RRB- cord-005453-4057qib7 12425 26 . . . cord-005453-4057qib7 12426 1 Type type NN cord-005453-4057qib7 12426 2 of of IN cord-005453-4057qib7 12426 3 monoclonal monoclonal JJ cord-005453-4057qib7 12426 4 component component NN cord-005453-4057qib7 12426 5 was be VBD cord-005453-4057qib7 12426 6 : : : cord-005453-4057qib7 12426 7 IgG IgG NNP cord-005453-4057qib7 12426 8 ( ( -LRB- cord-005453-4057qib7 12426 9 51.3 51.3 CD cord-005453-4057qib7 12426 10 % % NN cord-005453-4057qib7 12426 11 ) ) -RRB- cord-005453-4057qib7 12426 12 , , , cord-005453-4057qib7 12426 13 light light JJ cord-005453-4057qib7 12426 14 chains chain NNS cord-005453-4057qib7 12426 15 ( ( -LRB- cord-005453-4057qib7 12426 16 23.9 23.9 CD cord-005453-4057qib7 12426 17 % % NN cord-005453-4057qib7 12426 18 ) ) -RRB- cord-005453-4057qib7 12426 19 , , , cord-005453-4057qib7 12426 20 IgA IgA NNP cord-005453-4057qib7 12426 21 ( ( -LRB- cord-005453-4057qib7 12426 22 22.2 22.2 CD cord-005453-4057qib7 12426 23 % % NN cord-005453-4057qib7 12426 24 ) ) -RRB- cord-005453-4057qib7 12426 25 , , , cord-005453-4057qib7 12426 26 and and CC cord-005453-4057qib7 12426 27 non non JJ cord-005453-4057qib7 12426 28 - - JJ cord-005453-4057qib7 12426 29 secretory secretory JJ cord-005453-4057qib7 12426 30 ( ( -LRB- cord-005453-4057qib7 12426 31 2.6 2.6 CD cord-005453-4057qib7 12426 32 % % NN cord-005453-4057qib7 12426 33 ) ) -RRB- cord-005453-4057qib7 12426 34 . . . cord-005453-4057qib7 12427 1 51.3 51.3 CD cord-005453-4057qib7 12427 2 % % NN cord-005453-4057qib7 12427 3 had have VBD cord-005453-4057qib7 12427 4 Bence Bence NNP cord-005453-4057qib7 12427 5 Jones Jones NNP cord-005453-4057qib7 12427 6 proteinuria proteinuria NN cord-005453-4057qib7 12427 7 . . . cord-005453-4057qib7 12428 1 Conditioning conditioning NN cord-005453-4057qib7 12428 2 regimen regimen NN cord-005453-4057qib7 12428 3 was be VBD cord-005453-4057qib7 12428 4 Melphalan Melphalan NNP cord-005453-4057qib7 12428 5 200 200 CD cord-005453-4057qib7 12429 1 mg mg NNP cord-005453-4057qib7 12429 2 / / SYM cord-005453-4057qib7 12429 3 m m NNP cord-005453-4057qib7 12429 4 2 2 CD cord-005453-4057qib7 12429 5 in in IN cord-005453-4057qib7 12429 6 106 106 CD cord-005453-4057qib7 12429 7 ( ( -LRB- cord-005453-4057qib7 12429 8 90.6 90.6 CD cord-005453-4057qib7 12429 9 % % NN cord-005453-4057qib7 12429 10 ) ) -RRB- cord-005453-4057qib7 12429 11 , , , cord-005453-4057qib7 12429 12 Melphalan Melphalan NNP cord-005453-4057qib7 12429 13 100 100 CD cord-005453-4057qib7 12429 14 - - SYM cord-005453-4057qib7 12429 15 140 140 CD cord-005453-4057qib7 12430 1 mg mg NNP cord-005453-4057qib7 12430 2 / / SYM cord-005453-4057qib7 12430 3 m m NNP cord-005453-4057qib7 12430 4 2 2 CD cord-005453-4057qib7 12430 5 in in IN cord-005453-4057qib7 12430 6 9 9 CD cord-005453-4057qib7 12430 7 ( ( -LRB- cord-005453-4057qib7 12430 8 7.7 7.7 CD cord-005453-4057qib7 12430 9 % % NN cord-005453-4057qib7 12430 10 ) ) -RRB- cord-005453-4057qib7 12430 11 , , , cord-005453-4057qib7 12430 12 and and CC cord-005453-4057qib7 12430 13 other other JJ cord-005453-4057qib7 12430 14 in in IN cord-005453-4057qib7 12430 15 2 2 CD cord-005453-4057qib7 12430 16 ( ( -LRB- cord-005453-4057qib7 12430 17 1.7 1.7 CD cord-005453-4057qib7 12430 18 % % NN cord-005453-4057qib7 12430 19 ) ) -RRB- cord-005453-4057qib7 12430 20 . . . cord-005453-4057qib7 12431 1 Results result NNS cord-005453-4057qib7 12431 2 : : : cord-005453-4057qib7 12432 1 Pre pre JJ cord-005453-4057qib7 12432 2 - - JJ cord-005453-4057qib7 12432 3 transplant transplant NN cord-005453-4057qib7 12432 4 therapy therapy NN cord-005453-4057qib7 12432 5 was be VBD cord-005453-4057qib7 12432 6 : : : cord-005453-4057qib7 12432 7 VCD VCD NNP cord-005453-4057qib7 12432 8 in in IN cord-005453-4057qib7 12432 9 60 60 CD cord-005453-4057qib7 12432 10 ( ( -LRB- cord-005453-4057qib7 12432 11 mostly mostly RB cord-005453-4057qib7 12432 12 in in IN cord-005453-4057qib7 12432 13 2014 2014 CD cord-005453-4057qib7 12432 14 - - SYM cord-005453-4057qib7 12432 15 6 6 CD cord-005453-4057qib7 12432 16 ) ) -RRB- cord-005453-4057qib7 12432 17 , , . cord-005453-4057qib7 12433 1 VTD VTD NNP cord-005453-4057qib7 12433 2 / / SYM cord-005453-4057qib7 12433 3 VRD VRD NNP cord-005453-4057qib7 12433 4 / / SYM cord-005453-4057qib7 12433 5 KRD KRD NNP cord-005453-4057qib7 12433 6 in in IN cord-005453-4057qib7 12433 7 34 34 CD cord-005453-4057qib7 12433 8 ( ( -LRB- cord-005453-4057qib7 12433 9 mostly mostly RB cord-005453-4057qib7 12433 10 in in IN cord-005453-4057qib7 12433 11 2017 2017 CD cord-005453-4057qib7 12433 12 - - SYM cord-005453-4057qib7 12433 13 8 8 CD cord-005453-4057qib7 12433 14 ) ) -RRB- cord-005453-4057qib7 12433 15 , , , cord-005453-4057qib7 12433 16 and and CC cord-005453-4057qib7 12433 17 others other NNS cord-005453-4057qib7 12433 18 in in IN cord-005453-4057qib7 12433 19 23 23 CD cord-005453-4057qib7 12433 20 cases case NNS cord-005453-4057qib7 12433 21 . . . cord-005453-4057qib7 12434 1 Status status NN cord-005453-4057qib7 12434 2 of of IN cord-005453-4057qib7 12434 3 the the DT cord-005453-4057qib7 12434 4 disease disease NN cord-005453-4057qib7 12434 5 at at IN cord-005453-4057qib7 12434 6 transplant transplant NN cord-005453-4057qib7 12434 7 was be VBD cord-005453-4057qib7 12434 8 : : : cord-005453-4057qib7 12434 9 CR CR NNP cord-005453-4057qib7 12434 10 / / SYM cord-005453-4057qib7 12434 11 VGPR VGPR NNP cord-005453-4057qib7 12434 12 in in IN cord-005453-4057qib7 12434 13 75 75 CD cord-005453-4057qib7 12434 14 , , , cord-005453-4057qib7 12434 15 PR PR NNP cord-005453-4057qib7 12434 16 in in IN cord-005453-4057qib7 12434 17 35 35 CD cord-005453-4057qib7 12434 18 , , , cord-005453-4057qib7 12434 19 and and CC cord-005453-4057qib7 12434 20 SD SD NNP cord-005453-4057qib7 12434 21 in in IN cord-005453-4057qib7 12434 22 7 7 CD cord-005453-4057qib7 12434 23 . . . cord-005453-4057qib7 12435 1 Distribution distribution NN cord-005453-4057qib7 12435 2 of of IN cord-005453-4057qib7 12435 3 pretransplant pretransplant JJ cord-005453-4057qib7 12435 4 response response NN cord-005453-4057qib7 12435 5 based base VBN cord-005453-4057qib7 12435 6 on on IN cord-005453-4057qib7 12435 7 the the DT cord-005453-4057qib7 12435 8 type type NN cord-005453-4057qib7 12435 9 of of IN cord-005453-4057qib7 12435 10 induction induction NN cord-005453-4057qib7 12435 11 is be VBZ cord-005453-4057qib7 12435 12 shown show VBN cord-005453-4057qib7 12435 13 in in IN cord-005453-4057qib7 12435 14 table table NN cord-005453-4057qib7 12435 15 1 1 CD cord-005453-4057qib7 12435 16 . . . cord-005453-4057qib7 12436 1 Peri peri NN cord-005453-4057qib7 12436 2 - - HYPH cord-005453-4057qib7 12436 3 transplant transplant NN cord-005453-4057qib7 12436 4 mortality mortality NN cord-005453-4057qib7 12436 5 was be VBD cord-005453-4057qib7 12436 6 0 0 CD cord-005453-4057qib7 12436 7 % % NN cord-005453-4057qib7 12436 8 . . . cord-005453-4057qib7 12437 1 Day day NN cord-005453-4057qib7 12437 2 +100 +100 NNS cord-005453-4057qib7 12437 3 mortality mortality NN cord-005453-4057qib7 12437 4 was be VBD cord-005453-4057qib7 12437 5 1.7 1.7 CD cord-005453-4057qib7 12437 6 % % NN cord-005453-4057qib7 12437 7 ( ( -LRB- cord-005453-4057qib7 12437 8 2 2 CD cord-005453-4057qib7 12437 9 pts pts CD cord-005453-4057qib7 12437 10 ) ) -RRB- cord-005453-4057qib7 12437 11 , , , cord-005453-4057qib7 12437 12 due due IN cord-005453-4057qib7 12437 13 to to IN cord-005453-4057qib7 12437 14 progressive progressive JJ cord-005453-4057qib7 12437 15 disease disease NN cord-005453-4057qib7 12437 16 . . . cord-005453-4057qib7 12438 1 As as IN cord-005453-4057qib7 12438 2 shown show VBN cord-005453-4057qib7 12438 3 in in IN cord-005453-4057qib7 12438 4 table table NN cord-005453-4057qib7 12438 5 2 2 CD cord-005453-4057qib7 12438 6 , , , cord-005453-4057qib7 12438 7 all all DT cord-005453-4057qib7 12438 8 patients patient NNS cord-005453-4057qib7 12438 9 ( ( -LRB- cord-005453-4057qib7 12438 10 14/14 14/14 CD cord-005453-4057qib7 12438 11 ) ) -RRB- cord-005453-4057qib7 12438 12 who who WP cord-005453-4057qib7 12438 13 obtained obtain VBD cord-005453-4057qib7 12438 14 CR CR NNP cord-005453-4057qib7 12438 15 pre pre JJ cord-005453-4057qib7 12438 16 - - JJ cord-005453-4057qib7 12438 17 HSCT HSCT NNP cord-005453-4057qib7 12438 18 , , , cord-005453-4057qib7 12438 19 maintained maintain VBD cord-005453-4057qib7 12438 20 the the DT cord-005453-4057qib7 12438 21 response response NN cord-005453-4057qib7 12438 22 at at IN cord-005453-4057qib7 12438 23 day day NN cord-005453-4057qib7 12438 24 +100 +100 NFP cord-005453-4057qib7 12438 25 post post NN cord-005453-4057qib7 12438 26 - - JJ cord-005453-4057qib7 12438 27 HSCT HSCT NNP cord-005453-4057qib7 12438 28 . . . cord-005453-4057qib7 12439 1 Among among IN cord-005453-4057qib7 12439 2 the the DT cord-005453-4057qib7 12439 3 patients patient NNS cord-005453-4057qib7 12439 4 in in IN cord-005453-4057qib7 12439 5 VGPR VGPR NNP cord-005453-4057qib7 12439 6 at at IN cord-005453-4057qib7 12439 7 HSCT HSCT NNP cord-005453-4057qib7 12439 8 , , , cord-005453-4057qib7 12439 9 20 20 CD cord-005453-4057qib7 12439 10 ( ( -LRB- cord-005453-4057qib7 12439 11 32.8 32.8 CD cord-005453-4057qib7 12439 12 % % NN cord-005453-4057qib7 12439 13 ) ) -RRB- cord-005453-4057qib7 12439 14 became become VBD cord-005453-4057qib7 12439 15 into into IN cord-005453-4057qib7 12439 16 CR CR NNP cord-005453-4057qib7 12439 17 , , , cord-005453-4057qib7 12439 18 and and CC cord-005453-4057qib7 12439 19 37 37 CD cord-005453-4057qib7 12439 20 ( ( -LRB- cord-005453-4057qib7 12439 21 60.7 60.7 CD cord-005453-4057qib7 12439 22 % % NN cord-005453-4057qib7 12439 23 ) ) -RRB- cord-005453-4057qib7 12439 24 maintained maintain VBD cord-005453-4057qib7 12439 25 the the DT cord-005453-4057qib7 12439 26 response response NN cord-005453-4057qib7 12439 27 . . . cord-005453-4057qib7 12440 1 The the DT cord-005453-4057qib7 12440 2 CR cr NN cord-005453-4057qib7 12440 3 rate rate NN cord-005453-4057qib7 12440 4 at at IN cord-005453-4057qib7 12440 5 post post JJ cord-005453-4057qib7 12440 6 - - JJ cord-005453-4057qib7 12440 7 HSCT HSCT NNP cord-005453-4057qib7 12440 8 increased increase VBD cord-005453-4057qib7 12440 9 264 264 CD cord-005453-4057qib7 12440 10 % % NN cord-005453-4057qib7 12440 11 compared compare VBN cord-005453-4057qib7 12440 12 to to IN cord-005453-4057qib7 12440 13 pre pre JJ cord-005453-4057qib7 12440 14 - - JJ cord-005453-4057qib7 12440 15 HSCT HSCT NNP cord-005453-4057qib7 12440 16 ( ( -LRB- cord-005453-4057qib7 12440 17 37 37 CD cord-005453-4057qib7 12440 18 versus versus IN cord-005453-4057qib7 12440 19 14 14 CD cord-005453-4057qib7 12440 20 pts pt NNS cord-005453-4057qib7 12440 21 ) ) -RRB- cord-005453-4057qib7 12440 22 . . . cord-005453-4057qib7 12441 1 Altogether altogether RB cord-005453-4057qib7 12441 2 , , , cord-005453-4057qib7 12441 3 after after IN cord-005453-4057qib7 12441 4 HSCT HSCT NNP cord-005453-4057qib7 12441 5 44 44 CD cord-005453-4057qib7 12441 6 pts pt NNS cord-005453-4057qib7 12441 7 ( ( -LRB- cord-005453-4057qib7 12441 8 37.6 37.6 CD cord-005453-4057qib7 12441 9 % % NN cord-005453-4057qib7 12441 10 ) ) -RRB- cord-005453-4057qib7 12441 11 improved improve VBN cord-005453-4057qib7 12441 12 and and CC cord-005453-4057qib7 12441 13 65 65 CD cord-005453-4057qib7 12441 14 ( ( -LRB- cord-005453-4057qib7 12441 15 55.6 55.6 CD cord-005453-4057qib7 12441 16 % % NN cord-005453-4057qib7 12441 17 ) ) -RRB- cord-005453-4057qib7 12441 18 maintained maintain VBD cord-005453-4057qib7 12441 19 the the DT cord-005453-4057qib7 12441 20 pre pre JJ cord-005453-4057qib7 12441 21 - - JJ cord-005453-4057qib7 12441 22 HSCT hsct JJ cord-005453-4057qib7 12441 23 response response NN cord-005453-4057qib7 12441 24 . . . cord-005453-4057qib7 12442 1 During during IN cord-005453-4057qib7 12442 2 the the DT cord-005453-4057qib7 12442 3 last last JJ cord-005453-4057qib7 12442 4 period period NN cord-005453-4057qib7 12442 5 of of IN cord-005453-4057qib7 12442 6 time time NN cord-005453-4057qib7 12442 7 , , , cord-005453-4057qib7 12442 8 37 37 CD cord-005453-4057qib7 12442 9 pts pt NNS cord-005453-4057qib7 12442 10 started start VBD cord-005453-4057qib7 12442 11 on on IN cord-005453-4057qib7 12442 12 post post JJ cord-005453-4057qib7 12442 13 - - JJ cord-005453-4057qib7 12442 14 HSCT hsct JJ cord-005453-4057qib7 12442 15 maintenance maintenance NN cord-005453-4057qib7 12442 16 / / SYM cord-005453-4057qib7 12442 17 consolidation consolidation NN cord-005453-4057qib7 12442 18 , , , cord-005453-4057qib7 12442 19 mainly mainly RB cord-005453-4057qib7 12442 20 with with IN cord-005453-4057qib7 12442 21 lenalidomide lenalidomide NN cord-005453-4057qib7 12442 22 . . . cord-005453-4057qib7 12443 1 Conclusions conclusion NNS cord-005453-4057qib7 12443 2 : : : cord-005453-4057qib7 12444 1 1 1 LS cord-005453-4057qib7 12444 2 ) ) -RRB- cord-005453-4057qib7 12444 3 With with IN cord-005453-4057qib7 12444 4 the the DT cord-005453-4057qib7 12444 5 new new JJ cord-005453-4057qib7 12444 6 chemotherapeutic chemotherapeutic JJ cord-005453-4057qib7 12444 7 schemes scheme NNS cord-005453-4057qib7 12444 8 , , , cord-005453-4057qib7 12444 9 76.5 76.5 CD cord-005453-4057qib7 12444 10 % % NN cord-005453-4057qib7 12444 11 of of IN cord-005453-4057qib7 12444 12 patients patient NNS cord-005453-4057qib7 12444 13 underwent undergo VBD cord-005453-4057qib7 12444 14 HSCT HSCT NNP cord-005453-4057qib7 12444 15 in in IN cord-005453-4057qib7 12444 16 CR CR NNP cord-005453-4057qib7 12444 17 or or CC cord-005453-4057qib7 12444 18 VGPR VGPR NNP cord-005453-4057qib7 12444 19 ; ; : cord-005453-4057qib7 12445 1 2 2 LS cord-005453-4057qib7 12445 2 ) ) -RRB- cord-005453-4057qib7 12445 3 Majority majority NN cord-005453-4057qib7 12445 4 of of IN cord-005453-4057qib7 12445 5 pts pts NNP cord-005453-4057qib7 12445 6 ( ( -LRB- cord-005453-4057qib7 12445 7 93.2 93.2 CD cord-005453-4057qib7 12445 8 % % NN cord-005453-4057qib7 12445 9 ) ) -RRB- cord-005453-4057qib7 12445 10 consolidated consolidate VBN cord-005453-4057qib7 12445 11 or or CC cord-005453-4057qib7 12445 12 improved improve VBD cord-005453-4057qib7 12445 13 the the DT cord-005453-4057qib7 12445 14 pre pre JJ cord-005453-4057qib7 12445 15 - - JJ cord-005453-4057qib7 12445 16 HSCT hsct JJ cord-005453-4057qib7 12445 17 response response NN cord-005453-4057qib7 12446 1 ; ; : cord-005453-4057qib7 12446 2 3 3 LS cord-005453-4057qib7 12446 3 ) ) -RRB- cord-005453-4057qib7 12446 4 CR cr NN cord-005453-4057qib7 12446 5 increased increase VBD cord-005453-4057qib7 12446 6 substantially substantially RB cord-005453-4057qib7 12446 7 ( ( -LRB- cord-005453-4057qib7 12446 8 2.64 2.64 CD cord-005453-4057qib7 12446 9 times time NNS cord-005453-4057qib7 12446 10 ) ) -RRB- cord-005453-4057qib7 12446 11 after after IN cord-005453-4057qib7 12446 12 transplant transplant NN cord-005453-4057qib7 12446 13 ; ; : cord-005453-4057qib7 12446 14 4 4 LS cord-005453-4057qib7 12446 15 ) ) -RRB- cord-005453-4057qib7 12446 16 Optimized optimize VBN cord-005453-4057qib7 12446 17 induction induction NN cord-005453-4057qib7 12446 18 regimens regimen NNS cord-005453-4057qib7 12446 19 , , , cord-005453-4057qib7 12446 20 along along IN cord-005453-4057qib7 12446 21 with with IN cord-005453-4057qib7 12446 22 auto auto NN cord-005453-4057qib7 12446 23 - - HYPH cord-005453-4057qib7 12446 24 HSCT HSCT NNP cord-005453-4057qib7 12446 25 followed follow VBD cord-005453-4057qib7 12446 26 by by IN cord-005453-4057qib7 12446 27 the the DT cord-005453-4057qib7 12446 28 recently recently RB cord-005453-4057qib7 12446 29 licensed license VBN cord-005453-4057qib7 12446 30 use use NN cord-005453-4057qib7 12446 31 of of IN cord-005453-4057qib7 12446 32 maintenance maintenance NN cord-005453-4057qib7 12446 33 therapy therapy NN cord-005453-4057qib7 12446 34 with with IN cord-005453-4057qib7 12446 35 lenalidomide lenalidomide NN cord-005453-4057qib7 12446 36 , , , cord-005453-4057qib7 12446 37 might may MD cord-005453-4057qib7 12446 38 result result VB cord-005453-4057qib7 12446 39 in in IN cord-005453-4057qib7 12446 40 a a DT cord-005453-4057qib7 12446 41 better well JJR cord-005453-4057qib7 12446 42 PFS PFS NNP cord-005453-4057qib7 12446 43 of of IN cord-005453-4057qib7 12446 44 patients patient NNS cord-005453-4057qib7 12446 45 with with IN cord-005453-4057qib7 12446 46 MM MM NNP cord-005453-4057qib7 12446 47 . . . cord-005453-4057qib7 12447 1 Background background NN cord-005453-4057qib7 12447 2 : : : cord-005453-4057qib7 12448 1 Autologous autologous JJ cord-005453-4057qib7 12448 2 stem stem NN cord-005453-4057qib7 12448 3 cell cell NN cord-005453-4057qib7 12448 4 transplantation transplantation NN cord-005453-4057qib7 12448 5 ( ( -LRB- cord-005453-4057qib7 12448 6 ASCT ASCT NNP cord-005453-4057qib7 12448 7 ) ) -RRB- cord-005453-4057qib7 12448 8 is be VBZ cord-005453-4057qib7 12448 9 commonly commonly RB cord-005453-4057qib7 12448 10 used use VBN cord-005453-4057qib7 12448 11 in in IN cord-005453-4057qib7 12448 12 treatment treatment NN cord-005453-4057qib7 12448 13 of of IN cord-005453-4057qib7 12448 14 patients patient NNS cord-005453-4057qib7 12448 15 over over IN cord-005453-4057qib7 12448 16 65 65 CD cord-005453-4057qib7 12448 17 years year NNS cord-005453-4057qib7 12448 18 with with IN cord-005453-4057qib7 12448 19 multiple multiple JJ cord-005453-4057qib7 12448 20 myeloma myeloma NN cord-005453-4057qib7 12448 21 ( ( -LRB- cord-005453-4057qib7 12448 22 MM MM NNP cord-005453-4057qib7 12448 23 ) ) -RRB- cord-005453-4057qib7 12448 24 , , , cord-005453-4057qib7 12448 25 however however RB cord-005453-4057qib7 12448 26 the the DT cord-005453-4057qib7 12448 27 safety safety NN cord-005453-4057qib7 12448 28 and and CC cord-005453-4057qib7 12448 29 efficacy efficacy NN cord-005453-4057qib7 12448 30 of of IN cord-005453-4057qib7 12448 31 this this DT cord-005453-4057qib7 12448 32 procedure procedure NN cord-005453-4057qib7 12448 33 is be VBZ cord-005453-4057qib7 12448 34 debatable debatable JJ cord-005453-4057qib7 12448 35 . . . cord-005453-4057qib7 12449 1 Methods method NNS cord-005453-4057qib7 12449 2 : : : cord-005453-4057qib7 12449 3 We -PRON- PRP cord-005453-4057qib7 12449 4 conducted conduct VBD cord-005453-4057qib7 12449 5 a a DT cord-005453-4057qib7 12449 6 retrospective retrospective JJ cord-005453-4057qib7 12449 7 review review NN cord-005453-4057qib7 12449 8 of of IN cord-005453-4057qib7 12449 9 MM MM NNP cord-005453-4057qib7 12449 10 patients patient NNS cord-005453-4057qib7 12449 11 who who WP cord-005453-4057qib7 12449 12 underwent undergo VBD cord-005453-4057qib7 12449 13 ASCT ASCT NNP cord-005453-4057qib7 12449 14 from from IN cord-005453-4057qib7 12449 15 2013 2013 CD cord-005453-4057qib7 12449 16 to to IN cord-005453-4057qib7 12449 17 2018 2018 CD cord-005453-4057qib7 12449 18 at at IN cord-005453-4057qib7 12449 19 our -PRON- PRP$ cord-005453-4057qib7 12449 20 institution institution NN cord-005453-4057qib7 12449 21 . . . cord-005453-4057qib7 12450 1 The the DT cord-005453-4057qib7 12450 2 purpose purpose NN cord-005453-4057qib7 12450 3 of of IN cord-005453-4057qib7 12450 4 this this DT cord-005453-4057qib7 12450 5 retrospective retrospective JJ cord-005453-4057qib7 12450 6 study study NN cord-005453-4057qib7 12450 7 was be VBD cord-005453-4057qib7 12450 8 to to TO cord-005453-4057qib7 12450 9 compare compare VB cord-005453-4057qib7 12450 10 the the DT cord-005453-4057qib7 12450 11 100-day 100-day JJ cord-005453-4057qib7 12450 12 mortality mortality NN cord-005453-4057qib7 12450 13 , , , cord-005453-4057qib7 12450 14 time time NN cord-005453-4057qib7 12450 15 to to IN cord-005453-4057qib7 12450 16 engraftment engraftment NN cord-005453-4057qib7 12450 17 , , , cord-005453-4057qib7 12450 18 and and CC cord-005453-4057qib7 12450 19 incidence incidence NN cord-005453-4057qib7 12450 20 of of IN cord-005453-4057qib7 12450 21 grade grade NN cord-005453-4057qib7 12450 22 1 1 CD cord-005453-4057qib7 12450 23 - - SYM cord-005453-4057qib7 12450 24 4 4 CD cord-005453-4057qib7 12450 25 toxicities toxicity NNS cord-005453-4057qib7 12450 26 in in IN cord-005453-4057qib7 12450 27 elderly elderly JJ cord-005453-4057qib7 12450 28 MM MM NNP cord-005453-4057qib7 12450 29 patients patient NNS cord-005453-4057qib7 12450 30 with with IN cord-005453-4057qib7 12450 31 younger young JJR cord-005453-4057qib7 12450 32 patients patient NNS cord-005453-4057qib7 12450 33 taking take VBG cord-005453-4057qib7 12450 34 into into IN cord-005453-4057qib7 12450 35 account account NN cord-005453-4057qib7 12450 36 comorbidity comorbidity NN cord-005453-4057qib7 12450 37 information information NN cord-005453-4057qib7 12450 38 . . . cord-005453-4057qib7 12451 1 Other other JJ cord-005453-4057qib7 12451 2 secondary secondary JJ cord-005453-4057qib7 12451 3 end end NN cord-005453-4057qib7 12451 4 points point NNS cord-005453-4057qib7 12451 5 measured measure VBN cord-005453-4057qib7 12451 6 were be VBD cord-005453-4057qib7 12451 7 overall overall JJ cord-005453-4057qib7 12451 8 survival survival NN cord-005453-4057qib7 12451 9 ( ( -LRB- cord-005453-4057qib7 12451 10 OS OS NNP cord-005453-4057qib7 12451 11 ) ) -RRB- cord-005453-4057qib7 12451 12 and and CC cord-005453-4057qib7 12451 13 progression progression NN cord-005453-4057qib7 12451 14 - - HYPH cord-005453-4057qib7 12451 15 free free JJ cord-005453-4057qib7 12451 16 survival survival NN cord-005453-4057qib7 12451 17 ( ( -LRB- cord-005453-4057qib7 12451 18 PFS PFS NNP cord-005453-4057qib7 12451 19 ) ) -RRB- cord-005453-4057qib7 12451 20 . . . cord-005453-4057qib7 12452 1 Results result NNS cord-005453-4057qib7 12452 2 : : : cord-005453-4057qib7 12453 1 A a DT cord-005453-4057qib7 12453 2 total total NN cord-005453-4057qib7 12453 3 of of IN cord-005453-4057qib7 12453 4 95 95 CD cord-005453-4057qib7 12453 5 patients patient NNS cord-005453-4057qib7 12453 6 were be VBD cord-005453-4057qib7 12453 7 analysed analyse VBN cord-005453-4057qib7 12453 8 and and CC cord-005453-4057qib7 12453 9 categorized categorize VBN cord-005453-4057qib7 12453 10 by by IN cord-005453-4057qib7 12453 11 age age NN cord-005453-4057qib7 12453 12 as as IN cord-005453-4057qib7 12453 13 young young JJ cord-005453-4057qib7 12453 14 patients patient NNS cord-005453-4057qib7 12453 15 ( ( -LRB- cord-005453-4057qib7 12453 16 37 37 CD cord-005453-4057qib7 12453 17 to to TO cord-005453-4057qib7 12453 18 64 64 CD cord-005453-4057qib7 12453 19 y y NN cord-005453-4057qib7 12453 20 ; ; : cord-005453-4057qib7 12453 21 n=70 n=70 NNP cord-005453-4057qib7 12453 22 ) ) -RRB- cord-005453-4057qib7 12453 23 or or CC cord-005453-4057qib7 12453 24 elderly elderly JJ cord-005453-4057qib7 12453 25 ( ( -LRB- cord-005453-4057qib7 12453 26 65 65 CD cord-005453-4057qib7 12453 27 to to TO cord-005453-4057qib7 12453 28 71 71 CD cord-005453-4057qib7 12453 29 y y NN cord-005453-4057qib7 12453 30 ; ; : cord-005453-4057qib7 12454 1 n=25 n=25 NNP cord-005453-4057qib7 12454 2 ) ) -RRB- cord-005453-4057qib7 12454 3 . . . cord-005453-4057qib7 12455 1 The the DT cord-005453-4057qib7 12455 2 compared compare VBN cord-005453-4057qib7 12455 3 groups group NNS cord-005453-4057qib7 12455 4 did do VBD cord-005453-4057qib7 12455 5 not not RB cord-005453-4057qib7 12455 6 differ differ VB cord-005453-4057qib7 12455 7 in in IN cord-005453-4057qib7 12455 8 terms term NNS cord-005453-4057qib7 12455 9 of of IN cord-005453-4057qib7 12455 10 gender gender NN cord-005453-4057qib7 12455 11 , , , cord-005453-4057qib7 12455 12 ECOG ECOG NNP cord-005453-4057qib7 12455 13 , , , cord-005453-4057qib7 12455 14 HCT hct NN cord-005453-4057qib7 12455 15 - - HYPH cord-005453-4057qib7 12455 16 specific specific JJ cord-005453-4057qib7 12455 17 comorbidity comorbidity NN cord-005453-4057qib7 12455 18 index index NN cord-005453-4057qib7 12455 19 ( ( -LRB- cord-005453-4057qib7 12455 20 HCT HCT NNP cord-005453-4057qib7 12455 21 - - HYPH cord-005453-4057qib7 12455 22 CI CI NNP cord-005453-4057qib7 12455 23 ) ) -RRB- cord-005453-4057qib7 12455 24 , , , cord-005453-4057qib7 12455 25 and and CC cord-005453-4057qib7 12455 26 disease disease NN cord-005453-4057qib7 12455 27 status status NN cord-005453-4057qib7 12455 28 at at IN cord-005453-4057qib7 12455 29 ASCT ASCT NNP cord-005453-4057qib7 12455 30 . . . cord-005453-4057qib7 12456 1 Melphalan Melphalan NNP cord-005453-4057qib7 12456 2 in in IN cord-005453-4057qib7 12456 3 a a DT cord-005453-4057qib7 12456 4 dose dose NN cord-005453-4057qib7 12456 5 of of IN cord-005453-4057qib7 12456 6 200 200 CD cord-005453-4057qib7 12456 7 mg mg NNP cord-005453-4057qib7 12456 8 / / SYM cord-005453-4057qib7 12456 9 m m NNP cord-005453-4057qib7 12456 10 2 2 CD cord-005453-4057qib7 12456 11 was be VBD cord-005453-4057qib7 12456 12 used use VBN cord-005453-4057qib7 12456 13 as as IN cord-005453-4057qib7 12456 14 preparative preparative JJ cord-005453-4057qib7 12456 15 regimen regimen NN cord-005453-4057qib7 12456 16 in in IN cord-005453-4057qib7 12456 17 65 65 CD cord-005453-4057qib7 12456 18 % % NN cord-005453-4057qib7 12456 19 of of IN cord-005453-4057qib7 12456 20 younger young JJR cord-005453-4057qib7 12456 21 patients patient NNS cord-005453-4057qib7 12456 22 , , , cord-005453-4057qib7 12456 23 and and CC cord-005453-4057qib7 12456 24 in in IN cord-005453-4057qib7 12456 25 43 43 CD cord-005453-4057qib7 12456 26 % % NN cord-005453-4057qib7 12456 27 of of IN cord-005453-4057qib7 12456 28 the the DT cord-005453-4057qib7 12456 29 elderly elderly JJ cord-005453-4057qib7 12456 30 ( ( -LRB- cord-005453-4057qib7 12456 31 p= p= NNP cord-005453-4057qib7 12456 32 0.18 0.18 CD cord-005453-4057qib7 12456 33 ) ) -RRB- cord-005453-4057qib7 12456 34 . . . cord-005453-4057qib7 12457 1 The the DT cord-005453-4057qib7 12457 2 remaining remain VBG cord-005453-4057qib7 12457 3 patients patient NNS cord-005453-4057qib7 12457 4 received receive VBD cord-005453-4057qib7 12457 5 140 140 CD cord-005453-4057qib7 12457 6 mg mg NNP cord-005453-4057qib7 12457 7 / / SYM cord-005453-4057qib7 12457 8 m2 m2 NNP cord-005453-4057qib7 12457 9 of of IN cord-005453-4057qib7 12457 10 melphalan melphalan NNP cord-005453-4057qib7 12457 11 or or CC cord-005453-4057qib7 12457 12 lower low JJR cord-005453-4057qib7 12457 13 dose dose NN cord-005453-4057qib7 12457 14 ( ( -LRB- cord-005453-4057qib7 12458 1 range range NNP cord-005453-4057qib7 12458 2 , , , cord-005453-4057qib7 12458 3 100 100 CD cord-005453-4057qib7 12458 4 - - SYM cord-005453-4057qib7 12458 5 140 140 CD cord-005453-4057qib7 12458 6 mg mg NNP cord-005453-4057qib7 12458 7 / / SYM cord-005453-4057qib7 12458 8 m m NNP cord-005453-4057qib7 12458 9 2 2 CD cord-005453-4057qib7 12458 10 ) ) -RRB- cord-005453-4057qib7 12458 11 due due IN cord-005453-4057qib7 12458 12 to to IN cord-005453-4057qib7 12458 13 HCT HCT NNP cord-005453-4057qib7 12458 14 - - HYPH cord-005453-4057qib7 12458 15 CI ci NN cord-005453-4057qib7 12459 1 > > XX cord-005453-4057qib7 12459 2 2 2 CD cord-005453-4057qib7 12459 3 or or CC cord-005453-4057qib7 12459 4 age age NN cord-005453-4057qib7 12459 5 , , , cord-005453-4057qib7 12459 6 on on IN cord-005453-4057qib7 12459 7 the the DT cord-005453-4057qib7 12459 8 physician physician NN cord-005453-4057qib7 12459 9 discretion discretion NN cord-005453-4057qib7 12459 10 . . . cord-005453-4057qib7 12460 1 In in IN cord-005453-4057qib7 12460 2 the the DT cord-005453-4057qib7 12460 3 whole whole JJ cord-005453-4057qib7 12460 4 study study NN cord-005453-4057qib7 12460 5 group group NN cord-005453-4057qib7 12460 6 there there EX cord-005453-4057qib7 12460 7 were be VBD cord-005453-4057qib7 12460 8 no no DT cord-005453-4057qib7 12460 9 transplant transplant NN cord-005453-4057qib7 12460 10 related relate VBN cord-005453-4057qib7 12460 11 deaths death NNS cord-005453-4057qib7 12460 12 within within IN cord-005453-4057qib7 12460 13 the the DT cord-005453-4057qib7 12460 14 first first JJ cord-005453-4057qib7 12460 15 100 100 CD cord-005453-4057qib7 12460 16 days day NNS cord-005453-4057qib7 12460 17 of of IN cord-005453-4057qib7 12460 18 ASCT ASCT NNP cord-005453-4057qib7 12460 19 . . . cord-005453-4057qib7 12461 1 Stratifying stratify VBG cord-005453-4057qib7 12461 2 by by IN cord-005453-4057qib7 12461 3 age age NN cord-005453-4057qib7 12461 4 , , , cord-005453-4057qib7 12461 5 there there EX cord-005453-4057qib7 12461 6 was be VBD cord-005453-4057qib7 12461 7 no no DT cord-005453-4057qib7 12461 8 statistically statistically RB cord-005453-4057qib7 12461 9 significant significant JJ cord-005453-4057qib7 12461 10 difference difference NN cord-005453-4057qib7 12461 11 concerning concern VBG cord-005453-4057qib7 12461 12 febrile febrile JJ cord-005453-4057qib7 12461 13 neutropenia neutropenia NN cord-005453-4057qib7 12461 14 ( ( -LRB- cord-005453-4057qib7 12461 15 FN FN NNP cord-005453-4057qib7 12461 16 ) ) -RRB- cord-005453-4057qib7 12461 17 incidence incidence NN cord-005453-4057qib7 12461 18 , , , cord-005453-4057qib7 12461 19 which which WDT cord-005453-4057qib7 12461 20 was be VBD cord-005453-4057qib7 12461 21 observed observe VBN cord-005453-4057qib7 12461 22 in in IN cord-005453-4057qib7 12461 23 14 14 CD cord-005453-4057qib7 12461 24 % % NN cord-005453-4057qib7 12461 25 of of IN cord-005453-4057qib7 12461 26 younger young JJR cord-005453-4057qib7 12461 27 patients patient NNS cord-005453-4057qib7 12461 28 , , , cord-005453-4057qib7 12461 29 and and CC cord-005453-4057qib7 12461 30 17 17 CD cord-005453-4057qib7 12461 31 % % NN cord-005453-4057qib7 12461 32 of of IN cord-005453-4057qib7 12461 33 elderly elderly JJ cord-005453-4057qib7 12461 34 . . . cord-005453-4057qib7 12462 1 In in IN cord-005453-4057qib7 12462 2 contrast contrast NN cord-005453-4057qib7 12462 3 , , , cord-005453-4057qib7 12462 4 FN FN NNP cord-005453-4057qib7 12462 5 was be VBD cord-005453-4057qib7 12462 6 observed observe VBN cord-005453-4057qib7 12462 7 more more RBR cord-005453-4057qib7 12462 8 frequently frequently RB cord-005453-4057qib7 12462 9 in in IN cord-005453-4057qib7 12462 10 patients patient NNS cord-005453-4057qib7 12462 11 with with IN cord-005453-4057qib7 12462 12 HCT HCT NNP cord-005453-4057qib7 12462 13 - - HYPH cord-005453-4057qib7 12462 14 CI ci NN cord-005453-4057qib7 12462 15 > > XX cord-005453-4057qib7 12462 16 2 2 CD cord-005453-4057qib7 12462 17 ( ( -LRB- cord-005453-4057qib7 12462 18 38 38 CD cord-005453-4057qib7 12462 19 % % NN cord-005453-4057qib7 12462 20 vs vs IN cord-005453-4057qib7 12462 21 12 12 CD cord-005453-4057qib7 12462 22 % % NN cord-005453-4057qib7 12462 23 , , , cord-005453-4057qib7 12462 24 p=0.05 p=0.05 NNP cord-005453-4057qib7 12462 25 ) ) -RRB- cord-005453-4057qib7 12462 26 . . . cord-005453-4057qib7 12463 1 Grade grade NN cord-005453-4057qib7 12463 2 1 1 CD cord-005453-4057qib7 12463 3 - - SYM cord-005453-4057qib7 12463 4 2 2 CD cord-005453-4057qib7 12463 5 infections infection NNS cord-005453-4057qib7 12463 6 were be VBD cord-005453-4057qib7 12463 7 more more RBR cord-005453-4057qib7 12463 8 frequent frequent JJ cord-005453-4057qib7 12463 9 in in IN cord-005453-4057qib7 12463 10 older old JJR cord-005453-4057qib7 12463 11 patients patient NNS cord-005453-4057qib7 12463 12 ( ( -LRB- cord-005453-4057qib7 12463 13 35 35 CD cord-005453-4057qib7 12463 14 % % NN cord-005453-4057qib7 12463 15 vs vs IN cord-005453-4057qib7 12463 16 5 5 CD cord-005453-4057qib7 12463 17 % % NN cord-005453-4057qib7 12463 18 , , , cord-005453-4057qib7 12463 19 p= p= NNP cord-005453-4057qib7 12463 20 0.005 0.005 CD cord-005453-4057qib7 12463 21 ) ) -RRB- cord-005453-4057qib7 12463 22 , , , cord-005453-4057qib7 12463 23 but but CC cord-005453-4057qib7 12463 24 no no DT cord-005453-4057qib7 12463 25 difference difference NN cord-005453-4057qib7 12463 26 was be VBD cord-005453-4057qib7 12463 27 found find VBN cord-005453-4057qib7 12463 28 in in IN cord-005453-4057qib7 12463 29 grade grade NN cord-005453-4057qib7 12463 30 3 3 CD cord-005453-4057qib7 12463 31 - - SYM cord-005453-4057qib7 12463 32 4 4 CD cord-005453-4057qib7 12463 33 infections infection NNS cord-005453-4057qib7 12463 34 incidence incidence NN cord-005453-4057qib7 12463 35 rate rate NN cord-005453-4057qib7 12463 36 such such JJ cord-005453-4057qib7 12463 37 as as IN cord-005453-4057qib7 12463 38 pneumonia pneumonia NN cord-005453-4057qib7 12463 39 , , , cord-005453-4057qib7 12463 40 uroinfections uroinfection NNS cord-005453-4057qib7 12463 41 and and CC cord-005453-4057qib7 12463 42 neutropenic neutropenic JJ cord-005453-4057qib7 12463 43 enterocolitis enterocolitis NN cord-005453-4057qib7 12463 44 ( ( -LRB- cord-005453-4057qib7 12463 45 25 25 CD cord-005453-4057qib7 12463 46 % % NN cord-005453-4057qib7 12463 47 vs vs IN cord-005453-4057qib7 12463 48 35 35 CD cord-005453-4057qib7 12463 49 % % NN cord-005453-4057qib7 12463 50 , , , cord-005453-4057qib7 12463 51 p=0.52 p=0.52 NNP cord-005453-4057qib7 12463 52 ) ) -RRB- cord-005453-4057qib7 12463 53 , , , cord-005453-4057qib7 12463 54 nor nor CC cord-005453-4057qib7 12463 55 grade grade NN cord-005453-4057qib7 12463 56 1 1 CD cord-005453-4057qib7 12463 57 - - SYM cord-005453-4057qib7 12463 58 2 2 CD cord-005453-4057qib7 12463 59 and and CC cord-005453-4057qib7 12463 60 3 3 CD cord-005453-4057qib7 12463 61 - - SYM cord-005453-4057qib7 12463 62 4 4 CD cord-005453-4057qib7 12463 63 noninfectious noninfectious JJ cord-005453-4057qib7 12463 64 toxicities toxicity NNS cord-005453-4057qib7 12463 65 ( ( -LRB- cord-005453-4057qib7 12463 66 50 50 CD cord-005453-4057qib7 12463 67 % % NN cord-005453-4057qib7 12463 68 vs vs IN cord-005453-4057qib7 12463 69 38 38 CD cord-005453-4057qib7 12463 70 % % NN cord-005453-4057qib7 12463 71 , , , cord-005453-4057qib7 12463 72 p=0.31 p=0.31 NNP cord-005453-4057qib7 12463 73 , , , cord-005453-4057qib7 12463 74 and and CC cord-005453-4057qib7 12463 75 4 4 CD cord-005453-4057qib7 12463 76 % % NN cord-005453-4057qib7 12463 77 vs vs IN cord-005453-4057qib7 12463 78 21 21 CD cord-005453-4057qib7 12463 79 % % NN cord-005453-4057qib7 12463 80 , , , cord-005453-4057qib7 12463 81 p=0.06 p=0.06 JJ cord-005453-4057qib7 12463 82 , , , cord-005453-4057qib7 12463 83 respectively respectively RB cord-005453-4057qib7 12463 84 ) ) -RRB- cord-005453-4057qib7 12463 85 . . . cord-005453-4057qib7 12464 1 The the DT cord-005453-4057qib7 12464 2 median median JJ cord-005453-4057qib7 12464 3 time time NN cord-005453-4057qib7 12464 4 to to IN cord-005453-4057qib7 12464 5 granulocyte granulocyte NNP cord-005453-4057qib7 12464 6 engraftment engraftment NNP cord-005453-4057qib7 12464 7 was be VBD cord-005453-4057qib7 12464 8 11 11 CD cord-005453-4057qib7 12464 9 days day NNS cord-005453-4057qib7 12464 10 ( ( -LRB- cord-005453-4057qib7 12464 11 range range NN cord-005453-4057qib7 12464 12 , , , cord-005453-4057qib7 12464 13 9 9 CD cord-005453-4057qib7 12464 14 - - SYM cord-005453-4057qib7 12464 15 19 19 CD cord-005453-4057qib7 12464 16 days day NNS cord-005453-4057qib7 12464 17 ) ) -RRB- cord-005453-4057qib7 12464 18 in in IN cord-005453-4057qib7 12464 19 elderly elderly JJ cord-005453-4057qib7 12464 20 and and CC cord-005453-4057qib7 12464 21 was be VBD cord-005453-4057qib7 12464 22 comparable comparable JJ cord-005453-4057qib7 12464 23 with with IN cord-005453-4057qib7 12464 24 younger young JJR cord-005453-4057qib7 12464 25 patients patient NNS cord-005453-4057qib7 12464 26 . . . cord-005453-4057qib7 12465 1 The the DT cord-005453-4057qib7 12465 2 time time NN cord-005453-4057qib7 12465 3 to to IN cord-005453-4057qib7 12465 4 platelet platelet NN cord-005453-4057qib7 12465 5 recovery recovery NN cord-005453-4057qib7 12465 6 was be VBD cord-005453-4057qib7 12465 7 also also RB cord-005453-4057qib7 12465 8 similar similar JJ cord-005453-4057qib7 12465 9 . . . cord-005453-4057qib7 12466 1 After after IN cord-005453-4057qib7 12466 2 the the DT cord-005453-4057qib7 12466 3 median median JJ cord-005453-4057qib7 12466 4 follow follow NN cord-005453-4057qib7 12466 5 - - HYPH cord-005453-4057qib7 12466 6 up up NN cord-005453-4057qib7 12466 7 of of IN cord-005453-4057qib7 12466 8 12 12 CD cord-005453-4057qib7 12466 9 months month NNS cord-005453-4057qib7 12466 10 for for IN cord-005453-4057qib7 12466 11 survivors survivor NNS cord-005453-4057qib7 12466 12 , , , cord-005453-4057qib7 12466 13 OS OS NNP cord-005453-4057qib7 12466 14 at at IN cord-005453-4057qib7 12466 15 18 18 CD cord-005453-4057qib7 12466 16 months month NNS cord-005453-4057qib7 12466 17 was be VBD cord-005453-4057qib7 12466 18 94 94 CD cord-005453-4057qib7 12466 19 % % NN cord-005453-4057qib7 12466 20 in in IN cord-005453-4057qib7 12466 21 both both DT cord-005453-4057qib7 12466 22 groups group NNS cord-005453-4057qib7 12466 23 . . . cord-005453-4057qib7 12467 1 PFS PFS NNP cord-005453-4057qib7 12467 2 at at IN cord-005453-4057qib7 12467 3 18 18 CD cord-005453-4057qib7 12467 4 moths moth NNS cord-005453-4057qib7 12467 5 was be VBD cord-005453-4057qib7 12467 6 65 65 CD cord-005453-4057qib7 12467 7 % % NN cord-005453-4057qib7 12467 8 for for IN cord-005453-4057qib7 12467 9 younger young JJR cord-005453-4057qib7 12467 10 patients patient NNS cord-005453-4057qib7 12467 11 , , , cord-005453-4057qib7 12467 12 and and CC cord-005453-4057qib7 12467 13 55 55 CD cord-005453-4057qib7 12467 14 % % NN cord-005453-4057qib7 12467 15 for for IN cord-005453-4057qib7 12467 16 elderly elderly JJ cord-005453-4057qib7 12467 17 ( ( -LRB- cord-005453-4057qib7 12467 18 p=0.86).However p=0.86).however UH cord-005453-4057qib7 12467 19 , , , cord-005453-4057qib7 12467 20 the the DT cord-005453-4057qib7 12467 21 association association NN cord-005453-4057qib7 12467 22 between between IN cord-005453-4057qib7 12467 23 PFS PFS NNP cord-005453-4057qib7 12467 24 and and CC cord-005453-4057qib7 12467 25 the the DT cord-005453-4057qib7 12467 26 dose dose NN cord-005453-4057qib7 12467 27 of of IN cord-005453-4057qib7 12467 28 melphalan melphalan NNP cord-005453-4057qib7 12467 29 used use VBN cord-005453-4057qib7 12467 30 in in IN cord-005453-4057qib7 12467 31 conditioning conditioning NN cord-005453-4057qib7 12467 32 was be VBD cord-005453-4057qib7 12467 33 observed observe VBN cord-005453-4057qib7 12467 34 . . . cord-005453-4057qib7 12468 1 PFS PFS NNP cord-005453-4057qib7 12468 2 probability probability NN cord-005453-4057qib7 12468 3 at at IN cord-005453-4057qib7 12468 4 18 18 CD cord-005453-4057qib7 12468 5 months month NNS cord-005453-4057qib7 12468 6 for for IN cord-005453-4057qib7 12468 7 patients patient NNS cord-005453-4057qib7 12468 8 conditioned condition VBN cord-005453-4057qib7 12468 9 with with IN cord-005453-4057qib7 12468 10 the the DT cord-005453-4057qib7 12468 11 dose dose NN cord-005453-4057qib7 12468 12 of of IN cord-005453-4057qib7 12468 13 200 200 CD cord-005453-4057qib7 12468 14 mg mg NNP cord-005453-4057qib7 12468 15 / / SYM cord-005453-4057qib7 12468 16 m m NNP cord-005453-4057qib7 12468 17 2 2 CD cord-005453-4057qib7 12468 18 , , , cord-005453-4057qib7 12468 19 140 140 CD cord-005453-4057qib7 12468 20 mg mg NNP cord-005453-4057qib7 12468 21 / / SYM cord-005453-4057qib7 12468 22 m m NNP cord-005453-4057qib7 12468 23 2 2 CD cord-005453-4057qib7 12468 24 and and CC cord-005453-4057qib7 12468 25 100 100 CD cord-005453-4057qib7 12469 1 mg mg NNP cord-005453-4057qib7 12469 2 / / SYM cord-005453-4057qib7 12469 3 m m NNP cord-005453-4057qib7 12469 4 2 2 CD cord-005453-4057qib7 12469 5 was be VBD cord-005453-4057qib7 12469 6 71 71 CD cord-005453-4057qib7 12469 7 % % NN cord-005453-4057qib7 12469 8 , , , cord-005453-4057qib7 12469 9 58 58 CD cord-005453-4057qib7 12469 10 % % NN cord-005453-4057qib7 12469 11 and and CC cord-005453-4057qib7 12469 12 21 21 CD cord-005453-4057qib7 12469 13 % % NN cord-005453-4057qib7 12469 14 , , , cord-005453-4057qib7 12469 15 respectively respectively RB cord-005453-4057qib7 12469 16 ( ( -LRB- cord-005453-4057qib7 12469 17 p=0.012 p=0.012 NNP cord-005453-4057qib7 12469 18 ) ) -RRB- cord-005453-4057qib7 12469 19 . . . cord-005453-4057qib7 12470 1 Conclusions conclusion NNS cord-005453-4057qib7 12470 2 : : : cord-005453-4057qib7 12471 1 Our -PRON- PRP$ cord-005453-4057qib7 12471 2 data datum NNS cord-005453-4057qib7 12471 3 show show VBP cord-005453-4057qib7 12471 4 that that IN cord-005453-4057qib7 12471 5 ASCT ASCT NNP cord-005453-4057qib7 12471 6 in in IN cord-005453-4057qib7 12471 7 transplant transplant NN cord-005453-4057qib7 12471 8 eligible eligible JJ cord-005453-4057qib7 12471 9 MM MM NNP cord-005453-4057qib7 12471 10 patients patient NNS cord-005453-4057qib7 12472 1 ≥ ≥ CD cord-005453-4057qib7 12473 1 65 65 CD cord-005453-4057qib7 12473 2 years year NNS cord-005453-4057qib7 12473 3 of of IN cord-005453-4057qib7 12473 4 age age NN cord-005453-4057qib7 12473 5 is be VBZ cord-005453-4057qib7 12473 6 safe safe JJ cord-005453-4057qib7 12473 7 and and CC cord-005453-4057qib7 12473 8 provides provide VBZ cord-005453-4057qib7 12473 9 similar similar JJ cord-005453-4057qib7 12473 10 outcomes outcome NNS cord-005453-4057qib7 12473 11 as as IN cord-005453-4057qib7 12473 12 seen see VBN cord-005453-4057qib7 12473 13 in in IN cord-005453-4057qib7 12473 14 younger young JJR cord-005453-4057qib7 12473 15 patients patient NNS cord-005453-4057qib7 12473 16 . . . cord-005453-4057qib7 12474 1 Disclosure disclosure NN cord-005453-4057qib7 12474 2 : : : cord-005453-4057qib7 12475 1 Nothing nothing NN cord-005453-4057qib7 12475 2 to to TO cord-005453-4057qib7 12475 3 declare declare VB cord-005453-4057qib7 12475 4 Is be VBZ cord-005453-4057qib7 12475 5 mobilization mobilization NN cord-005453-4057qib7 12475 6 with with IN cord-005453-4057qib7 12475 7 chemotherapy chemotherapy NN cord-005453-4057qib7 12475 8 effect effect NN cord-005453-4057qib7 12475 9 response response NN cord-005453-4057qib7 12475 10 in in IN cord-005453-4057qib7 12475 11 the the DT cord-005453-4057qib7 12475 12 multiple multiple JJ cord-005453-4057qib7 12475 13 myeloma myeloma NN cord-005453-4057qib7 12475 14 ? ? . cord-005453-4057qib7 12476 1 Background background NN cord-005453-4057qib7 12476 2 : : : cord-005453-4057qib7 12477 1 High high JJ cord-005453-4057qib7 12477 2 dose dose NN cord-005453-4057qib7 12477 3 melphalan melphalan NN cord-005453-4057qib7 12477 4 therapy therapy NN cord-005453-4057qib7 12477 5 with with IN cord-005453-4057qib7 12477 6 autologous autologous JJ cord-005453-4057qib7 12477 7 stem stem NN cord-005453-4057qib7 12477 8 cell cell NN cord-005453-4057qib7 12477 9 support support NN cord-005453-4057qib7 12477 10 is be VBZ cord-005453-4057qib7 12477 11 a a DT cord-005453-4057qib7 12477 12 standart standart JJ cord-005453-4057qib7 12477 13 approach approach NN cord-005453-4057qib7 12477 14 in in IN cord-005453-4057qib7 12477 15 symptomatic symptomatic JJ cord-005453-4057qib7 12477 16 multiple multiple JJ cord-005453-4057qib7 12477 17 myeloma myeloma NN cord-005453-4057qib7 12477 18 patients patient NNS cord-005453-4057qib7 12477 19 . . . cord-005453-4057qib7 12478 1 Response response NN cord-005453-4057qib7 12478 2 rates rate NNS cord-005453-4057qib7 12478 3 increased increase VBD cord-005453-4057qib7 12478 4 with with IN cord-005453-4057qib7 12478 5 the the DT cord-005453-4057qib7 12478 6 novel novel JJ cord-005453-4057qib7 12478 7 anti anti JJ cord-005453-4057qib7 12478 8 myeloma myeloma NN cord-005453-4057qib7 12478 9 agents agent NNS cord-005453-4057qib7 12478 10 and and CC cord-005453-4057qib7 12478 11 the the DT cord-005453-4057qib7 12478 12 use use NN cord-005453-4057qib7 12478 13 of of IN cord-005453-4057qib7 12478 14 chemotherapy chemotherapy NN cord-005453-4057qib7 12478 15 for for IN cord-005453-4057qib7 12478 16 stem stem NN cord-005453-4057qib7 12478 17 cell cell NN cord-005453-4057qib7 12478 18 mobilization mobilization NN cord-005453-4057qib7 12478 19 should should MD cord-005453-4057qib7 12478 20 be be VB cord-005453-4057qib7 12478 21 questioned question VBN cord-005453-4057qib7 12478 22 . . . cord-005453-4057qib7 12479 1 The the DT cord-005453-4057qib7 12479 2 purpose purpose NN cord-005453-4057qib7 12479 3 of of IN cord-005453-4057qib7 12479 4 this this DT cord-005453-4057qib7 12479 5 study study NN cord-005453-4057qib7 12479 6 is be VBZ cord-005453-4057qib7 12479 7 to to TO cord-005453-4057qib7 12479 8 determine determine VB cord-005453-4057qib7 12479 9 the the DT cord-005453-4057qib7 12479 10 effect effect NN cord-005453-4057qib7 12479 11 of of IN cord-005453-4057qib7 12479 12 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12479 13 used use VBN cord-005453-4057qib7 12479 14 during during IN cord-005453-4057qib7 12479 15 stem stem NN cord-005453-4057qib7 12479 16 cell cell NN cord-005453-4057qib7 12479 17 collection collection NN cord-005453-4057qib7 12479 18 on on IN cord-005453-4057qib7 12479 19 disease disease NN cord-005453-4057qib7 12479 20 response response NN cord-005453-4057qib7 12479 21 and and CC cord-005453-4057qib7 12479 22 transplantation transplantation NN cord-005453-4057qib7 12479 23 results result NNS cord-005453-4057qib7 12479 24 . . . cord-005453-4057qib7 12480 1 Methods method NNS cord-005453-4057qib7 12480 2 : : : cord-005453-4057qib7 12480 3 We -PRON- PRP cord-005453-4057qib7 12480 4 retrospectively retrospectively RB cord-005453-4057qib7 12480 5 collect collect VBP cord-005453-4057qib7 12480 6 data datum NNS cord-005453-4057qib7 12480 7 from from IN cord-005453-4057qib7 12480 8 270 270 CD cord-005453-4057qib7 12480 9 myeloma myeloma NN cord-005453-4057qib7 12480 10 patients patient NNS cord-005453-4057qib7 12480 11 who who WP cord-005453-4057qib7 12480 12 underwent undergo VBD cord-005453-4057qib7 12480 13 autologous autologous JJ cord-005453-4057qib7 12480 14 stem stem NN cord-005453-4057qib7 12480 15 cell cell NN cord-005453-4057qib7 12480 16 transplantation transplantation NN cord-005453-4057qib7 12480 17 ( ( -LRB- cord-005453-4057qib7 12480 18 ASCT ASCT NNP cord-005453-4057qib7 12480 19 ) ) -RRB- cord-005453-4057qib7 12480 20 in in IN cord-005453-4057qib7 12480 21 Ankara Ankara NNP cord-005453-4057qib7 12480 22 University University NNP cord-005453-4057qib7 12480 23 Medicine Medicine NNP cord-005453-4057qib7 12480 24 Faculty Faculty NNP cord-005453-4057qib7 12480 25 , , , cord-005453-4057qib7 12480 26 blood blood NN cord-005453-4057qib7 12480 27 and and CC cord-005453-4057qib7 12480 28 bone bone NN cord-005453-4057qib7 12480 29 marrow marrow NN cord-005453-4057qib7 12480 30 transplantation transplantation NN cord-005453-4057qib7 12480 31 unit unit NN cord-005453-4057qib7 12480 32 between between IN cord-005453-4057qib7 12480 33 January January NNP cord-005453-4057qib7 12480 34 2012 2012 CD cord-005453-4057qib7 12480 35 and and CC cord-005453-4057qib7 12480 36 November November NNP cord-005453-4057qib7 12480 37 2018 2018 CD cord-005453-4057qib7 12480 38 . . . cord-005453-4057qib7 12481 1 51 51 CD cord-005453-4057qib7 12481 2 patients patient NNS cord-005453-4057qib7 12481 3 who who WP cord-005453-4057qib7 12481 4 received receive VBD cord-005453-4057qib7 12481 5 cyclophosphamide cyclophosphamide JJ cord-005453-4057qib7 12481 6 protocol protocol NN cord-005453-4057qib7 12481 7 for for IN cord-005453-4057qib7 12481 8 stem stem NN cord-005453-4057qib7 12481 9 cell cell NN cord-005453-4057qib7 12481 10 mobilization mobilization NN cord-005453-4057qib7 12481 11 were be VBD cord-005453-4057qib7 12481 12 included include VBN cord-005453-4057qib7 12481 13 in in IN cord-005453-4057qib7 12481 14 the the DT cord-005453-4057qib7 12481 15 study study NN cord-005453-4057qib7 12481 16 . . . cord-005453-4057qib7 12482 1 Disease disease NN cord-005453-4057qib7 12482 2 response response NN cord-005453-4057qib7 12482 3 were be VBD cord-005453-4057qib7 12482 4 determined determine VBN cord-005453-4057qib7 12482 5 according accord VBG cord-005453-4057qib7 12482 6 to to IN cord-005453-4057qib7 12482 7 International International NNP cord-005453-4057qib7 12482 8 Myeloma Myeloma NNP cord-005453-4057qib7 12482 9 Study Study NNP cord-005453-4057qib7 12482 10 Group Group NNP cord-005453-4057qib7 12482 11 ( ( -LRB- cord-005453-4057qib7 12482 12 IMWG IMWG NNP cord-005453-4057qib7 12482 13 ) ) -RRB- cord-005453-4057qib7 12482 14 criteria criterion NNS cord-005453-4057qib7 12482 15 before before IN cord-005453-4057qib7 12482 16 and and CC cord-005453-4057qib7 12482 17 after after IN cord-005453-4057qib7 12482 18 the the DT cord-005453-4057qib7 12482 19 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12482 20 . . . cord-005453-4057qib7 12483 1 Transplant transplant NN cord-005453-4057qib7 12483 2 responses response NNS cord-005453-4057qib7 12483 3 and and CC cord-005453-4057qib7 12483 4 their -PRON- PRP$ cord-005453-4057qib7 12483 5 effects effect NNS cord-005453-4057qib7 12483 6 on on IN cord-005453-4057qib7 12483 7 survival survival NN cord-005453-4057qib7 12483 8 were be VBD cord-005453-4057qib7 12483 9 also also RB cord-005453-4057qib7 12483 10 indicated indicate VBN cord-005453-4057qib7 12483 11 . . . cord-005453-4057qib7 12484 1 Results result NNS cord-005453-4057qib7 12484 2 : : : cord-005453-4057qib7 12485 1 After after IN cord-005453-4057qib7 12485 2 the the DT cord-005453-4057qib7 12485 3 diagnosis diagnosis NN cord-005453-4057qib7 12485 4 of of IN cord-005453-4057qib7 12485 5 MM MM NNP cord-005453-4057qib7 12485 6 , , , cord-005453-4057qib7 12485 7 51 51 CD cord-005453-4057qib7 12485 8 patients patient NNS cord-005453-4057qib7 12485 9 ( ( -LRB- cord-005453-4057qib7 12485 10 male/ male/ CD cord-005453-4057qib7 12485 11 female female NN cord-005453-4057qib7 12485 12 : : : cord-005453-4057qib7 12485 13 32/19 32/19 CD cord-005453-4057qib7 12485 14 ; ; : cord-005453-4057qib7 12485 15 median median JJ cord-005453-4057qib7 12485 16 age age NN cord-005453-4057qib7 12485 17 : : : cord-005453-4057qib7 12485 18 59 59 CD cord-005453-4057qib7 12485 19 years year NNS cord-005453-4057qib7 12485 20 ( ( -LRB- cord-005453-4057qib7 12485 21 between between IN cord-005453-4057qib7 12485 22 40 40 CD cord-005453-4057qib7 12485 23 - - SYM cord-005453-4057qib7 12485 24 74 74 CD cord-005453-4057qib7 12485 25 years year NNS cord-005453-4057qib7 12485 26 ) ) -RRB- cord-005453-4057qib7 12485 27 ) ) -RRB- cord-005453-4057qib7 12485 28 with with IN cord-005453-4057qib7 12485 29 median median JJ cord-005453-4057qib7 12485 30 follow follow NN cord-005453-4057qib7 12485 31 - - HYPH cord-005453-4057qib7 12485 32 up up NN cord-005453-4057qib7 12485 33 of of IN cord-005453-4057qib7 12485 34 59.1 59.1 CD cord-005453-4057qib7 12485 35 months month NNS cord-005453-4057qib7 12485 36 ( ( -LRB- cord-005453-4057qib7 12485 37 between between IN cord-005453-4057qib7 12485 38 7,6 7,6 CD cord-005453-4057qib7 12485 39 -185,8 -185,8 HYPH cord-005453-4057qib7 12485 40 months month NNS cord-005453-4057qib7 12485 41 ) ) -RRB- cord-005453-4057qib7 12485 42 underwent undergo VBD cord-005453-4057qib7 12485 43 ASCT ASCT NNP cord-005453-4057qib7 12485 44 at at IN cord-005453-4057qib7 12485 45 a a DT cord-005453-4057qib7 12485 46 mean mean NN cord-005453-4057qib7 12485 47 of of IN cord-005453-4057qib7 12485 48 21,7 21,7 CD cord-005453-4057qib7 12485 49 ±6,2 ±6,2 NNS cord-005453-4057qib7 12485 50 months month NNS cord-005453-4057qib7 12485 51 .. .. . cord-005453-4057qib7 12486 1 Forty forty CD cord-005453-4057qib7 12486 2 - - HYPH cord-005453-4057qib7 12486 3 one one CD cord-005453-4057qib7 12486 4 patients patient NNS cord-005453-4057qib7 12486 5 were be VBD cord-005453-4057qib7 12486 6 evaluated evaluate VBN cord-005453-4057qib7 12486 7 before before IN cord-005453-4057qib7 12486 8 and and CC cord-005453-4057qib7 12486 9 after after IN cord-005453-4057qib7 12486 10 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 12486 11 ( ( -LRB- cord-005453-4057qib7 12486 12 table table NN cord-005453-4057qib7 12486 13 1 1 CD cord-005453-4057qib7 12486 14 ) ) -RRB- cord-005453-4057qib7 12486 15 . . . cord-005453-4057qib7 12487 1 In in IN cord-005453-4057qib7 12487 2 69 69 CD cord-005453-4057qib7 12487 3 % % NN cord-005453-4057qib7 12487 4 of of IN cord-005453-4057qib7 12487 5 the the DT cord-005453-4057qib7 12487 6 patients patient NNS cord-005453-4057qib7 12487 7 , , , cord-005453-4057qib7 12487 8 the the DT cord-005453-4057qib7 12487 9 disease disease NN cord-005453-4057qib7 12487 10 response response NN cord-005453-4057qib7 12487 11 was be VBD cord-005453-4057qib7 12487 12 not not RB cord-005453-4057qib7 12487 13 altered alter VBN cord-005453-4057qib7 12487 14 by by IN cord-005453-4057qib7 12487 15 cyclophosphamide cyclophosphamide JJ cord-005453-4057qib7 12487 16 therapy therapy NN cord-005453-4057qib7 12487 17 , , , cord-005453-4057qib7 12487 18 and and CC cord-005453-4057qib7 12487 19 22 22 CD cord-005453-4057qib7 12487 20 % % NN cord-005453-4057qib7 12487 21 of of IN cord-005453-4057qib7 12487 22 the the DT cord-005453-4057qib7 12487 23 patients patient NNS cord-005453-4057qib7 12487 24 improved improve VBD cord-005453-4057qib7 12487 25 their -PRON- PRP$ cord-005453-4057qib7 12487 26 response response NN cord-005453-4057qib7 12487 27 status status NN cord-005453-4057qib7 12487 28 . . . cord-005453-4057qib7 12488 1 Post post JJ cord-005453-4057qib7 12488 2 - - JJ cord-005453-4057qib7 12488 3 transplant transplant JJ cord-005453-4057qib7 12488 4 response response NN cord-005453-4057qib7 12488 5 rates rate NNS cord-005453-4057qib7 12488 6 of of IN cord-005453-4057qib7 12488 7 patients patient NNS cord-005453-4057qib7 12488 8 who who WP cord-005453-4057qib7 12488 9 underwent undergo VBD cord-005453-4057qib7 12488 10 stem stem NN cord-005453-4057qib7 12488 11 cell cell NN cord-005453-4057qib7 12488 12 mobilization mobilization NN cord-005453-4057qib7 12488 13 with with IN cord-005453-4057qib7 12488 14 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12488 15 are be VBP cord-005453-4057qib7 12488 16 also also RB cord-005453-4057qib7 12488 17 shown show VBN cord-005453-4057qib7 12488 18 in in IN cord-005453-4057qib7 12488 19 table-1 table-1 NNP cord-005453-4057qib7 12488 20 . . . cord-005453-4057qib7 12489 1 The the DT cord-005453-4057qib7 12489 2 mean mean JJ cord-005453-4057qib7 12489 3 survival survival NN cord-005453-4057qib7 12489 4 of of IN cord-005453-4057qib7 12489 5 the the DT cord-005453-4057qib7 12489 6 patients patient NNS cord-005453-4057qib7 12489 7 was be VBD cord-005453-4057qib7 12489 8 52,7 52,7 CD cord-005453-4057qib7 12489 9 ±4,8 ±4,8 NN cord-005453-4057qib7 12489 10 months month NNS cord-005453-4057qib7 12489 11 . . . cord-005453-4057qib7 12490 1 When when WRB cord-005453-4057qib7 12490 2 patients patient NNS cord-005453-4057qib7 12490 3 were be VBD cord-005453-4057qib7 12490 4 grouped group VBN cord-005453-4057qib7 12490 5 according accord VBG cord-005453-4057qib7 12490 6 to to IN cord-005453-4057qib7 12490 7 changes change NNS cord-005453-4057qib7 12490 8 in in IN cord-005453-4057qib7 12490 9 response response NN cord-005453-4057qib7 12490 10 status status NN cord-005453-4057qib7 12490 11 before before IN cord-005453-4057qib7 12490 12 and and CC cord-005453-4057qib7 12490 13 after after IN cord-005453-4057qib7 12490 14 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 12490 15 ; ; : cord-005453-4057qib7 12490 16 there there EX cord-005453-4057qib7 12490 17 was be VBD cord-005453-4057qib7 12490 18 no no DT cord-005453-4057qib7 12490 19 statistical statistical JJ cord-005453-4057qib7 12490 20 difference difference NN cord-005453-4057qib7 12490 21 between between IN cord-005453-4057qib7 12490 22 mean mean JJ cord-005453-4057qib7 12490 23 calculated calculate VBN cord-005453-4057qib7 12490 24 survival survival NN cord-005453-4057qib7 12490 25 ( ( -LRB- cord-005453-4057qib7 12490 26 improved improved JJ cord-005453-4057qib7 12490 27 response response NN cord-005453-4057qib7 12490 28 , , , cord-005453-4057qib7 12490 29 disease disease NN cord-005453-4057qib7 12490 30 progression progression NN cord-005453-4057qib7 12490 31 and and CC cord-005453-4057qib7 12490 32 stable stable JJ cord-005453-4057qib7 12490 33 disease disease NN cord-005453-4057qib7 12490 34 ; ; : cord-005453-4057qib7 12490 35 59,3±9,0 59,3±9,0 CD cord-005453-4057qib7 12490 36 months month NNS cord-005453-4057qib7 12490 37 , , , cord-005453-4057qib7 12490 38 22,7±14,7 22,7±14,7 CD cord-005453-4057qib7 12490 39 months month NNS cord-005453-4057qib7 12490 40 and and CC cord-005453-4057qib7 12490 41 46,4±5,0 46,4±5,0 CD cord-005453-4057qib7 12490 42 months month NNS cord-005453-4057qib7 12490 43 respectively respectively RB cord-005453-4057qib7 12490 44 , , , cord-005453-4057qib7 12490 45 p=0.425 p=0.425 NNP cord-005453-4057qib7 12490 46 ) ) -RRB- cord-005453-4057qib7 12490 47 ( ( -LRB- cord-005453-4057qib7 12490 48 Figure-1 Figure-1 NNP cord-005453-4057qib7 12490 49 ) ) -RRB- cord-005453-4057qib7 12490 50 . . . cord-005453-4057qib7 12491 1 The the DT cord-005453-4057qib7 12491 2 rates rate NNS cord-005453-4057qib7 12491 3 of of IN cord-005453-4057qib7 12491 4 1-year 1-year CD cord-005453-4057qib7 12491 5 and and CC cord-005453-4057qib7 12491 6 3-year 3-year CD cord-005453-4057qib7 12491 7 overall overall JJ cord-005453-4057qib7 12491 8 survival survival NN cord-005453-4057qib7 12491 9 ( ( -LRB- cord-005453-4057qib7 12491 10 OS OS NNP cord-005453-4057qib7 12491 11 ) ) -RRB- cord-005453-4057qib7 12491 12 of of IN cord-005453-4057qib7 12491 13 the the DT cord-005453-4057qib7 12491 14 patients patient NNS cord-005453-4057qib7 12491 15 with with IN cord-005453-4057qib7 12491 16 no no DT cord-005453-4057qib7 12491 17 response response NN cord-005453-4057qib7 12491 18 to to IN cord-005453-4057qib7 12491 19 cyclophosphamide cyclophosphamide JJ cord-005453-4057qib7 12491 20 treatment treatment NN cord-005453-4057qib7 12491 21 were be VBD cord-005453-4057qib7 12491 22 as as IN cord-005453-4057qib7 12491 23 follows follow VBZ cord-005453-4057qib7 12491 24 ; ; : cord-005453-4057qib7 12491 25 74,2%±7,9 74,2%±7,9 CD cord-005453-4057qib7 12491 26 % % NN cord-005453-4057qib7 12491 27 and and CC cord-005453-4057qib7 12491 28 70,5%±8,3 70,5%±8,3 CD cord-005453-4057qib7 12491 29 % % NN cord-005453-4057qib7 12491 30 respectively respectively RB cord-005453-4057qib7 12491 31 . . . cord-005453-4057qib7 12492 1 Thirteen thirteen CD cord-005453-4057qib7 12492 2 patients patient NNS cord-005453-4057qib7 12492 3 who who WP cord-005453-4057qib7 12492 4 were be VBD cord-005453-4057qib7 12492 5 followed follow VBN cord-005453-4057qib7 12492 6 up up RP cord-005453-4057qib7 12492 7 median median NN cord-005453-4057qib7 12492 8 27 27 CD cord-005453-4057qib7 12492 9 months month NNS cord-005453-4057qib7 12492 10 after after IN cord-005453-4057qib7 12492 11 transplantation transplantation NN cord-005453-4057qib7 12492 12 died die VBD cord-005453-4057qib7 12492 13 at at IN cord-005453-4057qib7 12492 14 an an DT cord-005453-4057qib7 12492 15 average average NN cord-005453-4057qib7 12492 16 of of IN cord-005453-4057qib7 12492 17 3,4±2,5 3,4±2,5 CD cord-005453-4057qib7 12492 18 months month NNS cord-005453-4057qib7 12492 19 ; ; : cord-005453-4057qib7 12492 20 6 6 CD cord-005453-4057qib7 12492 21 of of IN cord-005453-4057qib7 12492 22 these these DT cord-005453-4057qib7 12492 23 deaths death NNS cord-005453-4057qib7 12492 24 were be VBD cord-005453-4057qib7 12492 25 caused cause VBN cord-005453-4057qib7 12492 26 by by IN cord-005453-4057qib7 12492 27 the the DT cord-005453-4057qib7 12492 28 infection infection NN cord-005453-4057qib7 12492 29 after after IN cord-005453-4057qib7 12492 30 transplantation transplantation NN cord-005453-4057qib7 12492 31 . . . cord-005453-4057qib7 12493 1 Conclusions conclusion NNS cord-005453-4057qib7 12493 2 : : : cord-005453-4057qib7 12494 1 In in IN cord-005453-4057qib7 12494 2 our -PRON- PRP$ cord-005453-4057qib7 12494 3 study study NN cord-005453-4057qib7 12494 4 , , , cord-005453-4057qib7 12494 5 it -PRON- PRP cord-005453-4057qib7 12494 6 was be VBD cord-005453-4057qib7 12494 7 observed observe VBN cord-005453-4057qib7 12494 8 that that IN cord-005453-4057qib7 12494 9 the the DT cord-005453-4057qib7 12494 10 use use NN cord-005453-4057qib7 12494 11 of of IN cord-005453-4057qib7 12494 12 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12494 13 for for IN cord-005453-4057qib7 12494 14 CD34 CD34 NNP cord-005453-4057qib7 12494 15 + + CC cord-005453-4057qib7 12494 16 stem stem NN cord-005453-4057qib7 12494 17 cell cell NN cord-005453-4057qib7 12494 18 mobilization mobilization NN cord-005453-4057qib7 12494 19 did do VBD cord-005453-4057qib7 12494 20 not not RB cord-005453-4057qib7 12494 21 change change VB cord-005453-4057qib7 12494 22 the the DT cord-005453-4057qib7 12494 23 disease disease NN cord-005453-4057qib7 12494 24 response response NN cord-005453-4057qib7 12494 25 rates rate NNS cord-005453-4057qib7 12494 26 by by IN cord-005453-4057qib7 12494 27 69 69 CD cord-005453-4057qib7 12494 28 % % NN cord-005453-4057qib7 12494 29 . . . cord-005453-4057qib7 12495 1 The the DT cord-005453-4057qib7 12495 2 posttransplant posttransplant NN cord-005453-4057qib7 12495 3 survival survival NN cord-005453-4057qib7 12495 4 rates rate NNS cord-005453-4057qib7 12495 5 of of IN cord-005453-4057qib7 12495 6 MM MM NNP cord-005453-4057qib7 12495 7 patients patient NNS cord-005453-4057qib7 12495 8 who who WP cord-005453-4057qib7 12495 9 had have VBD cord-005453-4057qib7 12495 10 progressive progressive JJ cord-005453-4057qib7 12495 11 disease disease NN cord-005453-4057qib7 12495 12 after after IN cord-005453-4057qib7 12495 13 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12495 14 use use NN cord-005453-4057qib7 12495 15 were be VBD cord-005453-4057qib7 12495 16 lower low JJR cord-005453-4057qib7 12495 17 . . . cord-005453-4057qib7 12496 1 However however RB cord-005453-4057qib7 12496 2 , , , cord-005453-4057qib7 12496 3 these these DT cord-005453-4057qib7 12496 4 results result NNS cord-005453-4057qib7 12496 5 warranted warrant VBN cord-005453-4057qib7 12496 6 confirmed confirm VBN cord-005453-4057qib7 12496 7 by by IN cord-005453-4057qib7 12496 8 randomized randomized JJ cord-005453-4057qib7 12496 9 controlled control VBN cord-005453-4057qib7 12496 10 trials trial NNS cord-005453-4057qib7 12496 11 . . . cord-005453-4057qib7 12497 1 Clinical clinical JJ cord-005453-4057qib7 12497 2 Trial Trial NNP cord-005453-4057qib7 12497 3 Registry Registry NNP cord-005453-4057qib7 12497 4 : : : cord-005453-4057qib7 12498 1 -Disclosure -disclosure UH cord-005453-4057qib7 12498 2 : : : cord-005453-4057qib7 12498 3 Nothing nothing NN cord-005453-4057qib7 12498 4 to to TO cord-005453-4057qib7 12498 5 declare declare VB cord-005453-4057qib7 12498 6 Results result NNS cord-005453-4057qib7 12498 7 of of IN cord-005453-4057qib7 12498 8 a a DT cord-005453-4057qib7 12498 9 single single JJ cord-005453-4057qib7 12498 10 center center NN cord-005453-4057qib7 12498 11 experience experience NN cord-005453-4057qib7 12498 12 : : : cord-005453-4057qib7 12498 13 An an DT cord-005453-4057qib7 12498 14 attempt attempt NN cord-005453-4057qib7 12498 15 to to TO cord-005453-4057qib7 12498 16 augment augment VB cord-005453-4057qib7 12498 17 conditioning conditioning NN cord-005453-4057qib7 12498 18 regimen regimen NN cord-005453-4057qib7 12498 19 in in IN cord-005453-4057qib7 12498 20 first first JJ cord-005453-4057qib7 12498 21 autologous autologous JJ cord-005453-4057qib7 12498 22 stem stem NN cord-005453-4057qib7 12498 23 cell cell NN cord-005453-4057qib7 12498 24 transplantation transplantation NN cord-005453-4057qib7 12498 25 treatment treatment NN cord-005453-4057qib7 12498 26 of of IN cord-005453-4057qib7 12498 27 multiple multiple JJ cord-005453-4057qib7 12498 28 myeloma myeloma NN cord-005453-4057qib7 12498 29 ( ( -LRB- cord-005453-4057qib7 12498 30 MM MM NNP cord-005453-4057qib7 12498 31 ) ) -RRB- cord-005453-4057qib7 12498 32 continues continue VBZ cord-005453-4057qib7 12498 33 to to TO cord-005453-4057qib7 12498 34 evolve evolve VB cord-005453-4057qib7 12498 35 in in IN cord-005453-4057qib7 12498 36 the the DT cord-005453-4057qib7 12498 37 era era NN cord-005453-4057qib7 12498 38 of of IN cord-005453-4057qib7 12498 39 novel novel JJ cord-005453-4057qib7 12498 40 agents agent NNS cord-005453-4057qib7 12498 41 . . . cord-005453-4057qib7 12499 1 The the DT cord-005453-4057qib7 12499 2 addition addition NN cord-005453-4057qib7 12499 3 of of IN cord-005453-4057qib7 12499 4 bortezomib bortezomib NNP cord-005453-4057qib7 12499 5 to to TO cord-005453-4057qib7 12499 6 highdose highdose VB cord-005453-4057qib7 12499 7 melphalan melphalan NNP cord-005453-4057qib7 12499 8 ( ( -LRB- cord-005453-4057qib7 12499 9 Bor Bor NNP cord-005453-4057qib7 12499 10 - - HYPH cord-005453-4057qib7 12499 11 HDM HDM NNP cord-005453-4057qib7 12499 12 ) ) -RRB- cord-005453-4057qib7 12499 13 has have VBZ cord-005453-4057qib7 12499 14 been be VBN cord-005453-4057qib7 12499 15 reported report VBN cord-005453-4057qib7 12499 16 by by IN cord-005453-4057qib7 12499 17 several several JJ cord-005453-4057qib7 12499 18 groups group NNS cord-005453-4057qib7 12499 19 , , , cord-005453-4057qib7 12499 20 and and CC cord-005453-4057qib7 12499 21 it -PRON- PRP cord-005453-4057qib7 12499 22 has have VBZ cord-005453-4057qib7 12499 23 been be VBN cord-005453-4057qib7 12499 24 outcome outcome VBN cord-005453-4057qib7 12499 25 and and CC cord-005453-4057qib7 12499 26 toxicity toxicity NN cord-005453-4057qib7 12499 27 profile profile NN cord-005453-4057qib7 12499 28 is be VBZ cord-005453-4057qib7 12499 29 comparable comparable JJ cord-005453-4057qib7 12499 30 to to IN cord-005453-4057qib7 12499 31 high high JJ cord-005453-4057qib7 12499 32 dose dose NN cord-005453-4057qib7 12499 33 melphalan melphalan NN cord-005453-4057qib7 12499 34 ( ( -LRB- cord-005453-4057qib7 12499 35 HDM HDM NNP cord-005453-4057qib7 12499 36 ) ) -RRB- cord-005453-4057qib7 12499 37 alone alone RB cord-005453-4057qib7 12499 38 . . . cord-005453-4057qib7 12500 1 The the DT cord-005453-4057qib7 12500 2 aim aim NN cord-005453-4057qib7 12500 3 of of IN cord-005453-4057qib7 12500 4 this this DT cord-005453-4057qib7 12500 5 retrospective retrospective JJ cord-005453-4057qib7 12500 6 study study NN cord-005453-4057qib7 12500 7 was be VBD cord-005453-4057qib7 12500 8 to to TO cord-005453-4057qib7 12500 9 evaluate evaluate VB cord-005453-4057qib7 12500 10 the the DT cord-005453-4057qib7 12500 11 outcome outcome NN cord-005453-4057qib7 12500 12 of of IN cord-005453-4057qib7 12500 13 the the DT cord-005453-4057qib7 12500 14 BOR BOR NNP cord-005453-4057qib7 12500 15 - - HYPH cord-005453-4057qib7 12500 16 HDM HDM NNP cord-005453-4057qib7 12500 17 conditioning conditioning NN cord-005453-4057qib7 12500 18 regimen regimen NN cord-005453-4057qib7 12500 19 on on IN cord-005453-4057qib7 12500 20 overall overall JJ cord-005453-4057qib7 12500 21 response response NN cord-005453-4057qib7 12500 22 for for IN cord-005453-4057qib7 12500 23 patients patient NNS cord-005453-4057qib7 12500 24 with with IN cord-005453-4057qib7 12500 25 MM MM NNP cord-005453-4057qib7 12500 26 undergoing undergo VBG cord-005453-4057qib7 12500 27 first first JJ cord-005453-4057qib7 12500 28 single single JJ cord-005453-4057qib7 12500 29 ASCT asct NN cord-005453-4057qib7 12500 30 at at IN cord-005453-4057qib7 12500 31 our -PRON- PRP$ cord-005453-4057qib7 12500 32 institution institution NN cord-005453-4057qib7 12500 33 . . . cord-005453-4057qib7 12501 1 Methods method NNS cord-005453-4057qib7 12501 2 : : : cord-005453-4057qib7 12502 1 This this DT cord-005453-4057qib7 12502 2 retrospective retrospective JJ cord-005453-4057qib7 12502 3 single single JJ cord-005453-4057qib7 12502 4 center center NN cord-005453-4057qib7 12502 5 study study NN cord-005453-4057qib7 12502 6 reviewed review VBD cord-005453-4057qib7 12502 7 136 136 CD cord-005453-4057qib7 12502 8 consecutive consecutive JJ cord-005453-4057qib7 12502 9 myeloma myeloma NN cord-005453-4057qib7 12502 10 patients patient NNS cord-005453-4057qib7 12502 11 who who WP cord-005453-4057qib7 12502 12 had have VBD cord-005453-4057qib7 12502 13 received receive VBN cord-005453-4057qib7 12502 14 the the DT cord-005453-4057qib7 12502 15 first first JJ cord-005453-4057qib7 12502 16 ASCT ASCT NNP cord-005453-4057qib7 12502 17 either either CC cord-005453-4057qib7 12502 18 with with IN cord-005453-4057qib7 12502 19 Bor Bor NNP cord-005453-4057qib7 12502 20 - - HYPH cord-005453-4057qib7 12502 21 HDM HDM NNP cord-005453-4057qib7 12502 22 ( ( -LRB- cord-005453-4057qib7 12502 23 n=15 n=15 NNP cord-005453-4057qib7 12502 24 , , , cord-005453-4057qib7 12502 25 M M NNP cord-005453-4057qib7 12502 26 / / SYM cord-005453-4057qib7 12502 27 F= F= NNP cord-005453-4057qib7 12502 28 11/4 11/4 CD cord-005453-4057qib7 12502 29 ) ) -RRB- cord-005453-4057qib7 12502 30 or or CC cord-005453-4057qib7 12502 31 single single JJ cord-005453-4057qib7 12502 32 agent agent NN cord-005453-4057qib7 12502 33 HDM HDM NNP cord-005453-4057qib7 12502 34 ( ( -LRB- cord-005453-4057qib7 12502 35 n=121 n=121 NNP cord-005453-4057qib7 12502 36 , , , cord-005453-4057qib7 12502 37 M M NNP cord-005453-4057qib7 12502 38 / / SYM cord-005453-4057qib7 12502 39 F= F= NNP cord-005453-4057qib7 12502 40 76/45 76/45 CD cord-005453-4057qib7 12502 41 ) ) -RRB- cord-005453-4057qib7 12502 42 conditioning conditioning NN cord-005453-4057qib7 12502 43 regimen regimen NN cord-005453-4057qib7 12502 44 . . . cord-005453-4057qib7 12503 1 In in IN cord-005453-4057qib7 12503 2 the the DT cord-005453-4057qib7 12503 3 single single JJ cord-005453-4057qib7 12503 4 agent agent NN cord-005453-4057qib7 12503 5 HDM HDM NNP cord-005453-4057qib7 12503 6 conditioning conditioning NN cord-005453-4057qib7 12503 7 regimen regimen NN cord-005453-4057qib7 12503 8 , , , cord-005453-4057qib7 12503 9 melphalan melphalan NNP cord-005453-4057qib7 12503 10 was be VBD cord-005453-4057qib7 12503 11 administered administer VBN cord-005453-4057qib7 12503 12 intravenously intravenously RB cord-005453-4057qib7 12503 13 at at IN cord-005453-4057qib7 12503 14 a a DT cord-005453-4057qib7 12503 15 total total JJ cord-005453-4057qib7 12503 16 dose dose NN cord-005453-4057qib7 12503 17 of of IN cord-005453-4057qib7 12503 18 200 200 CD cord-005453-4057qib7 12503 19 mg mg NNP cord-005453-4057qib7 12503 20 / / SYM cord-005453-4057qib7 12503 21 m2 m2 NNP cord-005453-4057qib7 12503 22 on on IN cord-005453-4057qib7 12503 23 day day NN cord-005453-4057qib7 12503 24 -3 -3 NNP cord-005453-4057qib7 12504 1 and and CC cord-005453-4057qib7 12504 2 -2 -2 CD cord-005453-4057qib7 12504 3 and and CC cord-005453-4057qib7 12504 4 stem stem NN cord-005453-4057qib7 12504 5 cells cell NNS cord-005453-4057qib7 12504 6 were be VBD cord-005453-4057qib7 12504 7 infused infuse VBN cord-005453-4057qib7 12504 8 on on IN cord-005453-4057qib7 12504 9 day day NN cord-005453-4057qib7 12504 10 0 0 CD cord-005453-4057qib7 12504 11 . . . cord-005453-4057qib7 12505 1 In in IN cord-005453-4057qib7 12505 2 the the DT cord-005453-4057qib7 12505 3 Bor Bor NNP cord-005453-4057qib7 12505 4 - - HYPH cord-005453-4057qib7 12505 5 HDM HDM NNP cord-005453-4057qib7 12505 6 group group NN cord-005453-4057qib7 12505 7 , , , cord-005453-4057qib7 12505 8 melphalan melphalan NNP cord-005453-4057qib7 12505 9 200mg 200mg NNP cord-005453-4057qib7 12505 10 / / SYM cord-005453-4057qib7 12505 11 m m NNP cord-005453-4057qib7 12505 12 2 2 CD cord-005453-4057qib7 12505 13 was be VBD cord-005453-4057qib7 12505 14 administered administer VBN cord-005453-4057qib7 12505 15 on on IN cord-005453-4057qib7 12505 16 day day NN cord-005453-4057qib7 12505 17 -2 -2 CD cord-005453-4057qib7 12505 18 . . . cord-005453-4057qib7 12506 1 Bortezomib Bortezomib NNP cord-005453-4057qib7 12506 2 was be VBD cord-005453-4057qib7 12506 3 administered administer VBN cord-005453-4057qib7 12506 4 intravenously intravenously RB cord-005453-4057qib7 12506 5 at at IN cord-005453-4057qib7 12506 6 a a DT cord-005453-4057qib7 12506 7 dose dose NN cord-005453-4057qib7 12506 8 of of IN cord-005453-4057qib7 12506 9 1 1 CD cord-005453-4057qib7 12506 10 mg mg NNP cord-005453-4057qib7 12506 11 / / SYM cord-005453-4057qib7 12506 12 m m NNP cord-005453-4057qib7 12506 13 2 2 CD cord-005453-4057qib7 12506 14 on on IN cord-005453-4057qib7 12506 15 day day NN cord-005453-4057qib7 12506 16 's 's POS cord-005453-4057qib7 12506 17 -6 -6 NNP cord-005453-4057qib7 12506 18 , , , cord-005453-4057qib7 12506 19 -3 -3 NNP cord-005453-4057qib7 12506 20 , , , cord-005453-4057qib7 12506 21 +1 +1 NNP cord-005453-4057qib7 12506 22 , , , cord-005453-4057qib7 12506 23 and and CC cord-005453-4057qib7 12506 24 +4 +4 NFP cord-005453-4057qib7 12506 25 as as IN cord-005453-4057qib7 12506 26 described describe VBN cord-005453-4057qib7 12506 27 in in IN cord-005453-4057qib7 12506 28 a a DT cord-005453-4057qib7 12506 29 phase phase NN cord-005453-4057qib7 12506 30 2 2 CD cord-005453-4057qib7 12506 31 study study NN cord-005453-4057qib7 12506 32 by by IN cord-005453-4057qib7 12506 33 Intergroupe Intergroupe NNP cord-005453-4057qib7 12506 34 Francophone Francophone NNP cord-005453-4057qib7 12506 35 du du NNP cord-005453-4057qib7 12506 36 Myeĺome Myeĺome NNP cord-005453-4057qib7 12506 37 ( ( -LRB- cord-005453-4057qib7 12506 38 IFM IFM NNP cord-005453-4057qib7 12506 39 ) ) -RRB- cord-005453-4057qib7 12506 40 . . . cord-005453-4057qib7 12507 1 Results result NNS cord-005453-4057qib7 12507 2 : : : cord-005453-4057qib7 12508 1 All all DT cord-005453-4057qib7 12508 2 consecutive consecutive JJ cord-005453-4057qib7 12508 3 patients patient NNS cord-005453-4057qib7 12508 4 who who WP cord-005453-4057qib7 12508 5 underwent undergo VBD cord-005453-4057qib7 12508 6 single single JJ cord-005453-4057qib7 12508 7 ASCT ASCT NNP cord-005453-4057qib7 12508 8 from from IN cord-005453-4057qib7 12508 9 January January NNP cord-005453-4057qib7 12508 10 2010 2010 CD cord-005453-4057qib7 12508 11 to to IN cord-005453-4057qib7 12508 12 March March NNP cord-005453-4057qib7 12508 13 2018 2018 CD cord-005453-4057qib7 12508 14 using use VBG cord-005453-4057qib7 12508 15 Bor Bor NNP cord-005453-4057qib7 12508 16 - - HYPH cord-005453-4057qib7 12508 17 HDM HDM NNP cord-005453-4057qib7 12508 18 as as IN cord-005453-4057qib7 12508 19 conditioning conditioning NN cord-005453-4057qib7 12508 20 or or CC cord-005453-4057qib7 12508 21 HDM HDM NNP cord-005453-4057qib7 12508 22 were be VBD cord-005453-4057qib7 12508 23 evaluated evaluate VBN cord-005453-4057qib7 12508 24 . . . cord-005453-4057qib7 12509 1 Conditioning conditioning NN cord-005453-4057qib7 12509 2 regimen regimen NN cord-005453-4057qib7 12509 3 was be VBD cord-005453-4057qib7 12509 4 HDM HDM NNP cord-005453-4057qib7 12509 5 in in IN cord-005453-4057qib7 12509 6 121 121 CD cord-005453-4057qib7 12509 7 patients patient NNS cord-005453-4057qib7 12509 8 and and CC cord-005453-4057qib7 12509 9 Bor Bor NNP cord-005453-4057qib7 12509 10 - - HYPH cord-005453-4057qib7 12509 11 HDM HDM NNP cord-005453-4057qib7 12509 12 in in IN cord-005453-4057qib7 12509 13 15 15 CD cord-005453-4057qib7 12509 14 patients patient NNS cord-005453-4057qib7 12509 15 . . . cord-005453-4057qib7 12510 1 Median median JJ cord-005453-4057qib7 12510 2 age age NN cord-005453-4057qib7 12510 3 was be VBD cord-005453-4057qib7 12510 4 significantly significantly RB cord-005453-4057qib7 12510 5 lower low JJR cord-005453-4057qib7 12510 6 in in IN cord-005453-4057qib7 12510 7 Bor Bor NNP cord-005453-4057qib7 12510 8 - - HYPH cord-005453-4057qib7 12510 9 HDM HDM NNP cord-005453-4057qib7 12510 10 conditioned condition VBD cord-005453-4057qib7 12510 11 ASCT ASCT NNP cord-005453-4057qib7 12510 12 compared compare VBN cord-005453-4057qib7 12510 13 to to IN cord-005453-4057qib7 12510 14 HDM HDM NNP cord-005453-4057qib7 12510 15 group group NN cord-005453-4057qib7 12510 16 ( ( -LRB- cord-005453-4057qib7 12510 17 62 62 CD cord-005453-4057qib7 12510 18 years year NNS cord-005453-4057qib7 12510 19 vs vs IN cord-005453-4057qib7 12510 20 52 52 CD cord-005453-4057qib7 12510 21 years year NNS cord-005453-4057qib7 12510 22 , , , cord-005453-4057qib7 12510 23 p=000 p=000 NNP cord-005453-4057qib7 12510 24 ) ) -RRB- cord-005453-4057qib7 12510 25 . . . cord-005453-4057qib7 12511 1 There there EX cord-005453-4057qib7 12511 2 was be VBD cord-005453-4057qib7 12511 3 no no DT cord-005453-4057qib7 12511 4 significant significant JJ cord-005453-4057qib7 12511 5 difference difference NN cord-005453-4057qib7 12511 6 for for IN cord-005453-4057qib7 12511 7 MM MM NNP cord-005453-4057qib7 12511 8 subtype subtype NN cord-005453-4057qib7 12511 9 , , , cord-005453-4057qib7 12511 10 ISS ISS NNP cord-005453-4057qib7 12511 11 stage stage NN cord-005453-4057qib7 12511 12 at at IN cord-005453-4057qib7 12511 13 diagnosis diagnosis NN cord-005453-4057qib7 12511 14 , , , cord-005453-4057qib7 12511 15 prior prior JJ cord-005453-4057qib7 12511 16 treatment treatment NN cord-005453-4057qib7 12511 17 line line NN cord-005453-4057qib7 12511 18 among among IN cord-005453-4057qib7 12511 19 HDM HDM NNP cord-005453-4057qib7 12511 20 vs vs IN cord-005453-4057qib7 12511 21 Bor Bor NNP cord-005453-4057qib7 12511 22 - - HYPH cord-005453-4057qib7 12511 23 HDM HDM NNP cord-005453-4057qib7 12511 24 cohorts cohort NNS cord-005453-4057qib7 12511 25 ( ( -LRB- cord-005453-4057qib7 12511 26 p>0.5 p>0.5 NNP cord-005453-4057qib7 12511 27 ) ) -RRB- cord-005453-4057qib7 12511 28 . . . cord-005453-4057qib7 12512 1 After after IN cord-005453-4057qib7 12512 2 a a DT cord-005453-4057qib7 12512 3 median median NN cord-005453-4057qib7 12512 4 of of IN cord-005453-4057qib7 12512 5 4 4 CD cord-005453-4057qib7 12512 6 cycles cycle NNS cord-005453-4057qib7 12512 7 of of IN cord-005453-4057qib7 12512 8 induction induction NN cord-005453-4057qib7 12512 9 chemotherapy chemotherapy NN cord-005453-4057qib7 12512 10 , , , cord-005453-4057qib7 12512 11 patients patient NNS cord-005453-4057qib7 12512 12 in in IN cord-005453-4057qib7 12512 13 the the DT cord-005453-4057qib7 12512 14 Bor Bor NNP cord-005453-4057qib7 12512 15 - - HYPH cord-005453-4057qib7 12512 16 HD HD NNP cord-005453-4057qib7 12512 17 exhibited exhibit VBD cord-005453-4057qib7 12512 18 ≥VGPR ≥vgpr NN cord-005453-4057qib7 12512 19 of of IN cord-005453-4057qib7 12512 20 53.8 53.8 CD cord-005453-4057qib7 12512 21 % % NN cord-005453-4057qib7 12512 22 ( ( -LRB- cord-005453-4057qib7 12512 23 n=7 n=7 NN cord-005453-4057qib7 12512 24 ) ) -RRB- cord-005453-4057qib7 12512 25 compared compare VBN cord-005453-4057qib7 12512 26 to to IN cord-005453-4057qib7 12512 27 56.7 56.7 CD cord-005453-4057qib7 12512 28 % % NN cord-005453-4057qib7 12512 29 ( ( -LRB- cord-005453-4057qib7 12512 30 n=51 n=51 NNP cord-005453-4057qib7 12512 31 ) ) -RRB- cord-005453-4057qib7 12512 32 in in IN cord-005453-4057qib7 12512 33 the the DT cord-005453-4057qib7 12512 34 HDM HDM NNP cord-005453-4057qib7 12512 35 group group NN cord-005453-4057qib7 12512 36 ( ( -LRB- cord-005453-4057qib7 12512 37 p= p= NNP cord-005453-4057qib7 12512 38 p>0.5 p>0.5 NNP cord-005453-4057qib7 12512 39 ) ) -RRB- cord-005453-4057qib7 12512 40 . . . cord-005453-4057qib7 12513 1 Pre pre JJ cord-005453-4057qib7 12513 2 - - JJ cord-005453-4057qib7 12513 3 ASCT asct JJ cord-005453-4057qib7 12513 4 immune immune JJ cord-005453-4057qib7 12513 5 response response NN cord-005453-4057qib7 12513 6 ( ( -LRB- cord-005453-4057qib7 12513 7 IF if NN cord-005453-4057qib7 12513 8 ( ( -LRB- cord-005453-4057qib7 12513 9 - - : cord-005453-4057qib7 12513 10 ) ) -RRB- cord-005453-4057qib7 12513 11 ) ) -RRB- cord-005453-4057qib7 12513 12 was be VBD cord-005453-4057qib7 12513 13 reported report VBN cord-005453-4057qib7 12513 14 in in IN cord-005453-4057qib7 12513 15 22.3 22.3 CD cord-005453-4057qib7 12513 16 % % NN cord-005453-4057qib7 12513 17 of of IN cord-005453-4057qib7 12513 18 patients patient NNS cord-005453-4057qib7 12513 19 treated treat VBN cord-005453-4057qib7 12513 20 with with IN cord-005453-4057qib7 12513 21 HDM HDM NNP cord-005453-4057qib7 12513 22 , , , cord-005453-4057qib7 12513 23 higher high JJR cord-005453-4057qib7 12513 24 than than IN cord-005453-4057qib7 12513 25 that that DT cord-005453-4057qib7 12513 26 seen see VBN cord-005453-4057qib7 12513 27 in in IN cord-005453-4057qib7 12513 28 the the DT cord-005453-4057qib7 12513 29 Bor Bor NNP cord-005453-4057qib7 12513 30 - - HYPH cord-005453-4057qib7 12513 31 HDM HDM NNP cord-005453-4057qib7 12513 32 group group NN cord-005453-4057qib7 12513 33 ( ( -LRB- cord-005453-4057qib7 12513 34 6.7 6.7 CD cord-005453-4057qib7 12513 35 % % NN cord-005453-4057qib7 12513 36 ) ) -RRB- cord-005453-4057qib7 12514 1 ( ( -LRB- cord-005453-4057qib7 12514 2 p=0.3 p=0.3 NNP cord-005453-4057qib7 12514 3 ) ) -RRB- cord-005453-4057qib7 12514 4 . . . cord-005453-4057qib7 12515 1 Nine nine CD cord-005453-4057qib7 12515 2 ( ( -LRB- cord-005453-4057qib7 12515 3 69.2 69.2 CD cord-005453-4057qib7 12515 4 % % NN cord-005453-4057qib7 12515 5 ) ) -RRB- cord-005453-4057qib7 12515 6 patients patient NNS cord-005453-4057qib7 12515 7 achieved achieve VBD cord-005453-4057qib7 12515 8 post post JJ cord-005453-4057qib7 12515 9 - - JJ cord-005453-4057qib7 12515 10 ASCT asct JJ cord-005453-4057qib7 12515 11 immune immune JJ cord-005453-4057qib7 12515 12 response response NN cord-005453-4057qib7 12515 13 ( ( -LRB- cord-005453-4057qib7 12515 14 IF if NN cord-005453-4057qib7 12515 15 ( ( -LRB- cord-005453-4057qib7 12515 16 - - : cord-005453-4057qib7 12515 17 ) ) -RRB- cord-005453-4057qib7 12515 18 ) ) -RRB- cord-005453-4057qib7 12516 1 ≥VGPR ≥vgpr NN cord-005453-4057qib7 12516 2 compared compare VBN cord-005453-4057qib7 12516 3 to to IN cord-005453-4057qib7 12516 4 92 92 CD cord-005453-4057qib7 12516 5 ( ( -LRB- cord-005453-4057qib7 12516 6 78.6 78.6 CD cord-005453-4057qib7 12516 7 % % NN cord-005453-4057qib7 12516 8 ) ) -RRB- cord-005453-4057qib7 12516 9 in in IN cord-005453-4057qib7 12516 10 the the DT cord-005453-4057qib7 12516 11 HDM HDM NNP cord-005453-4057qib7 12516 12 group group NN cord-005453-4057qib7 12516 13 . . . cord-005453-4057qib7 12517 1 At at IN cord-005453-4057qib7 12517 2 the the DT cord-005453-4057qib7 12517 3 time time NN cord-005453-4057qib7 12517 4 of of IN cord-005453-4057qib7 12517 5 this this DT cord-005453-4057qib7 12517 6 analysis analysis NN cord-005453-4057qib7 12517 7 , , , cord-005453-4057qib7 12517 8 ten ten CD cord-005453-4057qib7 12517 9 patients patient NNS cord-005453-4057qib7 12517 10 in in IN cord-005453-4057qib7 12517 11 the the DT cord-005453-4057qib7 12517 12 Bor Bor NNP cord-005453-4057qib7 12517 13 - - HYPH cord-005453-4057qib7 12517 14 HDM HDM NNP cord-005453-4057qib7 12517 15 group group NN cord-005453-4057qib7 12517 16 and and CC cord-005453-4057qib7 12517 17 87 87 CD cord-005453-4057qib7 12517 18 in in IN cord-005453-4057qib7 12517 19 the the DT cord-005453-4057qib7 12517 20 HDM HDM NNP cord-005453-4057qib7 12517 21 group group NN cord-005453-4057qib7 12517 22 had have VBD cord-005453-4057qib7 12517 23 already already RB cord-005453-4057qib7 12517 24 died die VBN cord-005453-4057qib7 12517 25 , , , cord-005453-4057qib7 12517 26 respectively respectively RB cord-005453-4057qib7 12517 27 ( ( -LRB- cord-005453-4057qib7 12517 28 p>0.5 p>0.5 NNP cord-005453-4057qib7 12517 29 ) ) -RRB- cord-005453-4057qib7 12517 30 . . . cord-005453-4057qib7 12518 1 A a DT cord-005453-4057qib7 12518 2 total total NN cord-005453-4057qib7 12518 3 of of IN cord-005453-4057qib7 12518 4 5 5 CD cord-005453-4057qib7 12518 5 ( ( -LRB- cord-005453-4057qib7 12518 6 45.5 45.5 CD cord-005453-4057qib7 12518 7 % % NN cord-005453-4057qib7 12518 8 ) ) -RRB- cord-005453-4057qib7 12518 9 patients patient NNS cord-005453-4057qib7 12518 10 in in IN cord-005453-4057qib7 12518 11 the the DT cord-005453-4057qib7 12518 12 Bor Bor NNP cord-005453-4057qib7 12518 13 - - HYPH cord-005453-4057qib7 12518 14 HDM HDM NNP cord-005453-4057qib7 12518 15 group group NN cord-005453-4057qib7 12518 16 and and CC cord-005453-4057qib7 12518 17 50 50 CD cord-005453-4057qib7 12518 18 ( ( -LRB- cord-005453-4057qib7 12518 19 44.2 44.2 CD cord-005453-4057qib7 12518 20 % % NN cord-005453-4057qib7 12518 21 ) ) -RRB- cord-005453-4057qib7 12518 22 patients patient NNS cord-005453-4057qib7 12518 23 in in IN cord-005453-4057qib7 12518 24 HDM HDM NNP cord-005453-4057qib7 12518 25 group group NN cord-005453-4057qib7 12518 26 had have VBD cord-005453-4057qib7 12518 27 already already RB cord-005453-4057qib7 12518 28 progressed progress VBN cord-005453-4057qib7 12518 29 ( ( -LRB- cord-005453-4057qib7 12518 30 p>0.5 p>0.5 NNP cord-005453-4057qib7 12518 31 ) ) -RRB- cord-005453-4057qib7 12518 32 . . . cord-005453-4057qib7 12519 1 Estimated estimate VBN cord-005453-4057qib7 12519 2 mean mean VBP cord-005453-4057qib7 12519 3 OS OS NNP cord-005453-4057qib7 12519 4 and and CC cord-005453-4057qib7 12519 5 PFS PFS NNP cord-005453-4057qib7 12519 6 was be VBD cord-005453-4057qib7 12519 7 shorter short JJR cord-005453-4057qib7 12519 8 for for IN cord-005453-4057qib7 12519 9 group group NN cord-005453-4057qib7 12519 10 treated treat VBN cord-005453-4057qib7 12519 11 with with IN cord-005453-4057qib7 12519 12 Bor Bor NNP cord-005453-4057qib7 12519 13 - - HYPH cord-005453-4057qib7 12519 14 HDM HDM NNP cord-005453-4057qib7 12519 15 ; ; : cord-005453-4057qib7 12519 16 48.2±6.9 48.2±6.9 CD cord-005453-4057qib7 12519 17 mos mos NN cord-005453-4057qib7 12519 18 and and CC cord-005453-4057qib7 12519 19 40.2±8.5 40.2±8.5 CD cord-005453-4057qib7 12519 20 mos mos NNP cord-005453-4057qib7 12519 21 vs. vs. FW cord-005453-4057qib7 12519 22 76.7±3.9 76.7±3.9 NNP cord-005453-4057qib7 12519 23 mos mos NNP cord-005453-4057qib7 12519 24 and and CC cord-005453-4057qib7 12519 25 67.3±3.8 67.3±3.8 CD cord-005453-4057qib7 12519 26 mos mos NN cord-005453-4057qib7 12519 27 , , , cord-005453-4057qib7 12519 28 respectively respectively RB cord-005453-4057qib7 12519 29 ( ( -LRB- cord-005453-4057qib7 12519 30 p>0.5 p>0.5 NNP cord-005453-4057qib7 12519 31 ) ) -RRB- cord-005453-4057qib7 12519 32 ( ( -LRB- cord-005453-4057qib7 12519 33 Figure-1 Figure-1 NNP cord-005453-4057qib7 12519 34 ) ) -RRB- cord-005453-4057qib7 12519 35 . . . cord-005453-4057qib7 12520 1 We -PRON- PRP cord-005453-4057qib7 12520 2 could could MD cord-005453-4057qib7 12520 3 not not RB cord-005453-4057qib7 12520 4 demonstrate demonstrate VB cord-005453-4057qib7 12520 5 the the DT cord-005453-4057qib7 12520 6 impact impact NN cord-005453-4057qib7 12520 7 of of IN cord-005453-4057qib7 12520 8 pre pre JJ cord-005453-4057qib7 12520 9 or or CC cord-005453-4057qib7 12520 10 post post JJ cord-005453-4057qib7 12520 11 transplant transplant NN cord-005453-4057qib7 12520 12 ≥VGPR ≥vgpr NN cord-005453-4057qib7 12520 13 immune immune JJ cord-005453-4057qib7 12520 14 response response NN cord-005453-4057qib7 12520 15 on on IN cord-005453-4057qib7 12520 16 survival survival NN cord-005453-4057qib7 12520 17 and and CC cord-005453-4057qib7 12520 18 disease disease NN cord-005453-4057qib7 12520 19 free free JJ cord-005453-4057qib7 12520 20 survival survival NN cord-005453-4057qib7 12520 21 . . . cord-005453-4057qib7 12521 1 There there EX cord-005453-4057qib7 12521 2 was be VBD cord-005453-4057qib7 12521 3 no no DT cord-005453-4057qib7 12521 4 engraftment engraftment NN cord-005453-4057qib7 12521 5 failure failure NN cord-005453-4057qib7 12521 6 observed observe VBN cord-005453-4057qib7 12521 7 on on IN cord-005453-4057qib7 12521 8 either either DT cord-005453-4057qib7 12521 9 treatment treatment NN cord-005453-4057qib7 12521 10 group group NN cord-005453-4057qib7 12521 11 and and CC cord-005453-4057qib7 12521 12 no no DT cord-005453-4057qib7 12521 13 worsening worsen VBG cord-005453-4057qib7 12521 14 peripheral peripheral JJ cord-005453-4057qib7 12521 15 neuropathy neuropathy NN cord-005453-4057qib7 12521 16 was be VBD cord-005453-4057qib7 12521 17 developed develop VBN cord-005453-4057qib7 12521 18 in in IN cord-005453-4057qib7 12521 19 the the DT cord-005453-4057qib7 12521 20 bortezomib bortezomib NNP cord-005453-4057qib7 12521 21 arm arm NN cord-005453-4057qib7 12521 22 . . . cord-005453-4057qib7 12522 1 Conclusions conclusion NNS cord-005453-4057qib7 12522 2 : : : cord-005453-4057qib7 12523 1 This this DT cord-005453-4057qib7 12523 2 single single JJ cord-005453-4057qib7 12523 3 center center NN cord-005453-4057qib7 12523 4 experience experience NN cord-005453-4057qib7 12523 5 on on IN cord-005453-4057qib7 12523 6 a a DT cord-005453-4057qib7 12523 7 small small JJ cord-005453-4057qib7 12523 8 patient patient JJ cord-005453-4057qib7 12523 9 pool pool NN cord-005453-4057qib7 12523 10 was be VBD cord-005453-4057qib7 12523 11 able able JJ cord-005453-4057qib7 12523 12 to to TO cord-005453-4057qib7 12523 13 repeat repeat VB cord-005453-4057qib7 12523 14 the the DT cord-005453-4057qib7 12523 15 prospective prospective JJ cord-005453-4057qib7 12523 16 randomized randomized JJ cord-005453-4057qib7 12523 17 study study NN cord-005453-4057qib7 12523 18 results result NNS cord-005453-4057qib7 12523 19 of of IN cord-005453-4057qib7 12523 20 IFM IFM NNP cord-005453-4057qib7 12523 21 . . . cord-005453-4057qib7 12524 1 Further further JJ cord-005453-4057qib7 12524 2 studies study NNS cord-005453-4057qib7 12524 3 are be VBP cord-005453-4057qib7 12524 4 warranted warrant VBN cord-005453-4057qib7 12524 5 to to TO cord-005453-4057qib7 12524 6 explore explore VB cord-005453-4057qib7 12524 7 this this DT cord-005453-4057qib7 12524 8 regimen regimen NN cord-005453-4057qib7 12524 9 , , , cord-005453-4057qib7 12524 10 especially especially RB cord-005453-4057qib7 12524 11 when when WRB cord-005453-4057qib7 12524 12 induction induction NN cord-005453-4057qib7 12524 13 treatment treatment NN cord-005453-4057qib7 12524 14 with with IN cord-005453-4057qib7 12524 15 novel novel JJ cord-005453-4057qib7 12524 16 agents agent NNS cord-005453-4057qib7 12524 17 are be VBP cord-005453-4057qib7 12524 18 employed employ VBN cord-005453-4057qib7 12524 19 , , , cord-005453-4057qib7 12524 20 with with IN cord-005453-4057qib7 12524 21 special special JJ cord-005453-4057qib7 12524 22 emphasis emphasis NN cord-005453-4057qib7 12524 23 on on IN cord-005453-4057qib7 12524 24 the the DT cord-005453-4057qib7 12524 25 high high JJ cord-005453-4057qib7 12524 26 - - HYPH cord-005453-4057qib7 12524 27 risk risk NN cord-005453-4057qib7 12524 28 myeloma myeloma NN cord-005453-4057qib7 12524 29 patients patient NNS cord-005453-4057qib7 12524 30 where where WRB cord-005453-4057qib7 12524 31 response response NN cord-005453-4057qib7 12524 32 rates rate NNS cord-005453-4057qib7 12524 33 are be VBP cord-005453-4057qib7 12524 34 good good JJ cord-005453-4057qib7 12524 35 but but CC cord-005453-4057qib7 12524 36 sustainability sustainability NN cord-005453-4057qib7 12524 37 remains remain VBZ cord-005453-4057qib7 12524 38 an an DT cord-005453-4057qib7 12524 39 issue issue NN cord-005453-4057qib7 12524 40 . . . cord-005453-4057qib7 12525 1 Disclosure disclosure NN cord-005453-4057qib7 12525 2 : : : cord-005453-4057qib7 12525 3 Nothing nothing NN cord-005453-4057qib7 12525 4 to to TO cord-005453-4057qib7 12525 5 disclosure disclosure VB cord-005453-4057qib7 12525 6 The the DT cord-005453-4057qib7 12525 7 efficacy efficacy NN cord-005453-4057qib7 12525 8 and and CC cord-005453-4057qib7 12525 9 safety safety NN cord-005453-4057qib7 12525 10 of of IN cord-005453-4057qib7 12525 11 bortezomib bortezomib NNP cord-005453-4057qib7 12525 12 plus plus CC cord-005453-4057qib7 12525 13 busulfan/ busulfan/ NNP cord-005453-4057qib7 12525 14 melphalan melphalan NNP cord-005453-4057qib7 12525 15 as as IN cord-005453-4057qib7 12525 16 conditioning conditioning NN cord-005453-4057qib7 12525 17 regimen regimen NN cord-005453-4057qib7 12525 18 in in IN cord-005453-4057qib7 12525 19 multiple multiple JJ cord-005453-4057qib7 12525 20 myeloma myeloma NN cord-005453-4057qib7 12525 21 undergoing undergo VBG cord-005453-4057qib7 12525 22 autologous autologous JJ cord-005453-4057qib7 12525 23 stem stem NN cord-005453-4057qib7 12525 24 cell cell NN cord-005453-4057qib7 12525 25 transplantation transplantation NN cord-005453-4057qib7 12525 26 : : : cord-005453-4057qib7 12526 1 PHASE phase NN cord-005453-4057qib7 12526 2 1/2 1/2 CD cord-005453-4057qib7 12526 3 study study NN cord-005453-4057qib7 12526 4 Background background NN cord-005453-4057qib7 12526 5 : : : cord-005453-4057qib7 12526 6 Bortezomib Bortezomib NNP cord-005453-4057qib7 12526 7 have have VBP cord-005453-4057qib7 12526 8 a a DT cord-005453-4057qib7 12526 9 powerful powerful JJ cord-005453-4057qib7 12526 10 antimyeloma antimyeloma NN cord-005453-4057qib7 12526 11 activity activity NN cord-005453-4057qib7 12526 12 and and CC cord-005453-4057qib7 12526 13 was be VBD cord-005453-4057qib7 12526 14 regarded regard VBN cord-005453-4057qib7 12526 15 as as IN cord-005453-4057qib7 12526 16 backbone backbone NN cord-005453-4057qib7 12526 17 of of IN cord-005453-4057qib7 12526 18 therapy therapy NN cord-005453-4057qib7 12526 19 in in IN cord-005453-4057qib7 12526 20 the the DT cord-005453-4057qib7 12526 21 past past JJ cord-005453-4057qib7 12526 22 decade decade NN cord-005453-4057qib7 12526 23 but but CC cord-005453-4057qib7 12526 24 its -PRON- PRP$ cord-005453-4057qib7 12526 25 safety safety NN cord-005453-4057qib7 12526 26 and and CC cord-005453-4057qib7 12526 27 efficacy efficacy NN cord-005453-4057qib7 12526 28 as as IN cord-005453-4057qib7 12526 29 a a DT cord-005453-4057qib7 12526 30 part part NN cord-005453-4057qib7 12526 31 of of IN cord-005453-4057qib7 12526 32 busulfan/ busulfan/ ADD cord-005453-4057qib7 12526 33 melphalan melphalan NNP cord-005453-4057qib7 12526 34 conditioning conditioning NN cord-005453-4057qib7 12526 35 regimen regimen NN cord-005453-4057qib7 12526 36 of of IN cord-005453-4057qib7 12526 37 autologous autologous JJ cord-005453-4057qib7 12526 38 stem stem NN cord-005453-4057qib7 12526 39 cell cell NN cord-005453-4057qib7 12526 40 transplantation transplantation NN cord-005453-4057qib7 12526 41 is be VBZ cord-005453-4057qib7 12526 42 yet yet RB cord-005453-4057qib7 12526 43 to to TO cord-005453-4057qib7 12526 44 be be VB cord-005453-4057qib7 12526 45 shown show VBN cord-005453-4057qib7 12526 46 . . . cord-005453-4057qib7 12527 1 Methods method NNS cord-005453-4057qib7 12527 2 : : : cord-005453-4057qib7 12528 1 A a DT cord-005453-4057qib7 12528 2 phase phase NN cord-005453-4057qib7 12528 3 1/2 1/2 CD cord-005453-4057qib7 12528 4 trial trial NN cord-005453-4057qib7 12528 5 to to TO cord-005453-4057qib7 12528 6 explore explore VB cord-005453-4057qib7 12528 7 the the DT cord-005453-4057qib7 12528 8 safety safety NN cord-005453-4057qib7 12528 9 and and CC cord-005453-4057qib7 12528 10 activity activity NN cord-005453-4057qib7 12528 11 of of IN cord-005453-4057qib7 12528 12 a a DT cord-005453-4057qib7 12528 13 bortezomib bortezomib NN cord-005453-4057qib7 12528 14 on on IN cord-005453-4057qib7 12528 15 days day NNS cord-005453-4057qib7 12528 16 -6 -6 NNP cord-005453-4057qib7 12528 17 , , , cord-005453-4057qib7 12528 18 -3 -3 NNP cord-005453-4057qib7 12528 19 , , , cord-005453-4057qib7 12528 20 and and CC cord-005453-4057qib7 12528 21 +1 +1 LS cord-005453-4057qib7 12528 22 added add VBD cord-005453-4057qib7 12528 23 to to IN cord-005453-4057qib7 12528 24 a a DT cord-005453-4057qib7 12528 25 conditioning conditioning NN cord-005453-4057qib7 12528 26 regimen regimen NN cord-005453-4057qib7 12528 27 with with IN cord-005453-4057qib7 12528 28 busulfan busulfan NNP cord-005453-4057qib7 12528 29 and and CC cord-005453-4057qib7 12528 30 melphalan melphalan NNP cord-005453-4057qib7 12528 31 ( ( -LRB- cord-005453-4057qib7 12528 32 BuMel BuMel NNP cord-005453-4057qib7 12528 33 , , , cord-005453-4057qib7 12528 34 3.2 3.2 CD cord-005453-4057qib7 12528 35 mg mg NNP cord-005453-4057qib7 12528 36 / / SYM cord-005453-4057qib7 12528 37 kg kg NNP cord-005453-4057qib7 12528 38 / / SYM cord-005453-4057qib7 12528 39 day day NN cord-005453-4057qib7 12528 40 and and CC cord-005453-4057qib7 12528 41 busulfan busulfan NN cord-005453-4057qib7 12528 42 during during IN cord-005453-4057qib7 12528 43 day day NN cord-005453-4057qib7 12528 44 -5 -5 NNP cord-005453-4057qib7 12529 1 and and CC cord-005453-4057qib7 12529 2 -3 -3 NNP cord-005453-4057qib7 12529 3 , , , cord-005453-4057qib7 12529 4 140 140 CD cord-005453-4057qib7 12529 5 mg/ mg/ NN cord-005453-4057qib7 12529 6 m m CD cord-005453-4057qib7 12529 7 2 2 CD cord-005453-4057qib7 12529 8 /day /day CD cord-005453-4057qib7 12529 9 of of IN cord-005453-4057qib7 12529 10 melphalan melphalan NNP cord-005453-4057qib7 12529 11 on on IN cord-005453-4057qib7 12529 12 the the DT cord-005453-4057qib7 12529 13 day day NN cord-005453-4057qib7 12529 14 -2 -2 CD cord-005453-4057qib7 12529 15 ) ) -RRB- cord-005453-4057qib7 12529 16 , , , cord-005453-4057qib7 12529 17 in in IN cord-005453-4057qib7 12529 18 multiple multiple JJ cord-005453-4057qib7 12529 19 myeloma myeloma NN cord-005453-4057qib7 12529 20 ( ( -LRB- cord-005453-4057qib7 12529 21 MM MM NNP cord-005453-4057qib7 12529 22 ) ) -RRB- cord-005453-4057qib7 12529 23 patients patient NNS cord-005453-4057qib7 12529 24 who who WP cord-005453-4057qib7 12529 25 received receive VBD cord-005453-4057qib7 12529 26 autologous autologous JJ cord-005453-4057qib7 12529 27 stem stem NN cord-005453-4057qib7 12529 28 cell cell NN cord-005453-4057qib7 12529 29 transplantation transplantation NN cord-005453-4057qib7 12529 30 following follow VBG cord-005453-4057qib7 12529 31 bortezomib bortezomib NNP cord-005453-4057qib7 12529 32 - - HYPH cord-005453-4057qib7 12529 33 based base VBN cord-005453-4057qib7 12529 34 induction induction NN cord-005453-4057qib7 12529 35 chemotherapy chemotherapy NN cord-005453-4057qib7 12529 36 . . . cord-005453-4057qib7 12530 1 In in IN cord-005453-4057qib7 12530 2 Phase phase NN cord-005453-4057qib7 12530 3 1 1 CD cord-005453-4057qib7 12530 4 , , , cord-005453-4057qib7 12530 5 escalating escalate VBG cord-005453-4057qib7 12530 6 doses dose NNS cord-005453-4057qib7 12530 7 ( ( -LRB- cord-005453-4057qib7 12530 8 0.7 0.7 CD cord-005453-4057qib7 12530 9 , , , cord-005453-4057qib7 12530 10 1.0 1.0 CD cord-005453-4057qib7 12530 11 , , , cord-005453-4057qib7 12530 12 and and CC cord-005453-4057qib7 12530 13 1.3 1.3 CD cord-005453-4057qib7 12530 14 mg mg NNP cord-005453-4057qib7 12530 15 / / SYM cord-005453-4057qib7 12530 16 m m NNP cord-005453-4057qib7 12530 17 2 2 CD cord-005453-4057qib7 12530 18 ) ) -RRB- cord-005453-4057qib7 12530 19 of of IN cord-005453-4057qib7 12530 20 bortezomib bortezomib NNP cord-005453-4057qib7 12530 21 with with IN cord-005453-4057qib7 12530 22 BuMel BuMel NNP cord-005453-4057qib7 12530 23 were be VBD cord-005453-4057qib7 12530 24 administered administer VBN cord-005453-4057qib7 12530 25 in in IN cord-005453-4057qib7 12530 26 each each DT cord-005453-4057qib7 12530 27 group group NN cord-005453-4057qib7 12530 28 with with IN cord-005453-4057qib7 12530 29 three three CD cord-005453-4057qib7 12530 30 patients patient NNS cord-005453-4057qib7 12530 31 . . . cord-005453-4057qib7 12531 1 With with IN cord-005453-4057qib7 12531 2 determined determined JJ cord-005453-4057qib7 12531 3 maximum maximum NN cord-005453-4057qib7 12531 4 tolerated tolerate VBN cord-005453-4057qib7 12531 5 dose dose NN cord-005453-4057qib7 12531 6 of of IN cord-005453-4057qib7 12531 7 bortzomib bortzomib NNP cord-005453-4057qib7 12531 8 at at IN cord-005453-4057qib7 12531 9 a a DT cord-005453-4057qib7 12531 10 1.3mg 1.3mg CD cord-005453-4057qib7 12531 11 / / SYM cord-005453-4057qib7 12531 12 m m CD cord-005453-4057qib7 12531 13 2 2 CD cord-005453-4057qib7 12531 14 /day /day CD cord-005453-4057qib7 12531 15 , , , cord-005453-4057qib7 12531 16 cohort cohort NN cord-005453-4057qib7 12531 17 with with IN cord-005453-4057qib7 12531 18 41 41 CD cord-005453-4057qib7 12531 19 patients patient NNS cord-005453-4057qib7 12531 20 were be VBD cord-005453-4057qib7 12531 21 analyzed analyze VBN cord-005453-4057qib7 12531 22 for for IN cord-005453-4057qib7 12531 23 Phase phase NN cord-005453-4057qib7 12531 24 2 2 CD cord-005453-4057qib7 12531 25 . . . cord-005453-4057qib7 12532 1 Results result NNS cord-005453-4057qib7 12532 2 : : : cord-005453-4057qib7 12533 1 In in IN cord-005453-4057qib7 12533 2 Phase phase NN cord-005453-4057qib7 12533 3 1 1 CD cord-005453-4057qib7 12533 4 , , , cord-005453-4057qib7 12533 5 no no DT cord-005453-4057qib7 12533 6 dose dose NN cord-005453-4057qib7 12533 7 limiting limit VBG cord-005453-4057qib7 12533 8 toxicity toxicity NN cord-005453-4057qib7 12533 9 was be VBD cord-005453-4057qib7 12533 10 observed observe VBN cord-005453-4057qib7 12533 11 at at IN cord-005453-4057qib7 12533 12 a a DT cord-005453-4057qib7 12533 13 1.3mg 1.3mg CD cord-005453-4057qib7 12533 14 / / SYM cord-005453-4057qib7 12533 15 m m NN cord-005453-4057qib7 12533 16 2 2 CD cord-005453-4057qib7 12533 17 /day /day CD cord-005453-4057qib7 12533 18 of of IN cord-005453-4057qib7 12533 19 bortezomib bortezomib NNP cord-005453-4057qib7 12533 20 . . . cord-005453-4057qib7 12534 1 In in IN cord-005453-4057qib7 12534 2 Phase phase NN cord-005453-4057qib7 12534 3 2 2 CD cord-005453-4057qib7 12534 4 , , , cord-005453-4057qib7 12534 5 overall overall JJ cord-005453-4057qib7 12534 6 responses response NNS cord-005453-4057qib7 12534 7 at at IN cord-005453-4057qib7 12534 8 3 3 CD cord-005453-4057qib7 12534 9 months month NNS cord-005453-4057qib7 12534 10 was be VBD cord-005453-4057qib7 12534 11 shown show VBN cord-005453-4057qib7 12534 12 as as IN cord-005453-4057qib7 12534 13 75 75 CD cord-005453-4057qib7 12534 14 % % NN cord-005453-4057qib7 12534 15 of of IN cord-005453-4057qib7 12534 16 very very RB cord-005453-4057qib7 12534 17 good good JJ cord-005453-4057qib7 12534 18 partial partial JJ cord-005453-4057qib7 12534 19 response response NN cord-005453-4057qib7 12534 20 ( ( -LRB- cord-005453-4057qib7 12534 21 VGPR VGPR NNP cord-005453-4057qib7 12534 22 ) ) -RRB- cord-005453-4057qib7 12534 23 or or CC cord-005453-4057qib7 12534 24 better well JJR cord-005453-4057qib7 12534 25 and and CC cord-005453-4057qib7 12534 26 55 55 CD cord-005453-4057qib7 12534 27 % % NN cord-005453-4057qib7 12534 28 of of IN cord-005453-4057qib7 12534 29 complete complete JJ cord-005453-4057qib7 12534 30 response response NN cord-005453-4057qib7 12534 31 ( ( -LRB- cord-005453-4057qib7 12534 32 CR CR NNP cord-005453-4057qib7 12534 33 ) ) -RRB- cord-005453-4057qib7 12534 34 , , , cord-005453-4057qib7 12534 35 whereas whereas IN cord-005453-4057qib7 12534 36 post post JJ cord-005453-4057qib7 12534 37 - - JJ cord-005453-4057qib7 12534 38 transplant transplant JJ cord-005453-4057qib7 12534 39 overall overall RB cord-005453-4057qib7 12534 40 best good JJS cord-005453-4057qib7 12534 41 response response NN cord-005453-4057qib7 12534 42 included include VBD cord-005453-4057qib7 12534 43 83 83 CD cord-005453-4057qib7 12534 44 % % NN cord-005453-4057qib7 12534 45 of of IN cord-005453-4057qib7 12534 46 VGPR vgpr NN cord-005453-4057qib7 12534 47 or or CC cord-005453-4057qib7 12534 48 better well JJR cord-005453-4057qib7 12534 49 , , , cord-005453-4057qib7 12534 50 and and CC cord-005453-4057qib7 12534 51 68 68 CD cord-005453-4057qib7 12534 52 % % NN cord-005453-4057qib7 12534 53 of of IN cord-005453-4057qib7 12534 54 CR cr NN cord-005453-4057qib7 12534 55 , , , cord-005453-4057qib7 12534 56 respectively respectively RB cord-005453-4057qib7 12534 57 . . . cord-005453-4057qib7 12535 1 With with IN cord-005453-4057qib7 12535 2 median median JJ cord-005453-4057qib7 12535 3 follow follow NN cord-005453-4057qib7 12535 4 - - HYPH cord-005453-4057qib7 12535 5 up up NN cord-005453-4057qib7 12535 6 duration duration NN cord-005453-4057qib7 12535 7 of of IN cord-005453-4057qib7 12535 8 31.4 31.4 CD cord-005453-4057qib7 12535 9 months month NNS cord-005453-4057qib7 12535 10 , , , cord-005453-4057qib7 12535 11 median median JJ cord-005453-4057qib7 12535 12 progression progression NN cord-005453-4057qib7 12535 13 - - HYPH cord-005453-4057qib7 12535 14 free free JJ cord-005453-4057qib7 12535 15 survival survival NN cord-005453-4057qib7 12535 16 ( ( -LRB- cord-005453-4057qib7 12535 17 PFS PFS NNP cord-005453-4057qib7 12535 18 ) ) -RRB- cord-005453-4057qib7 12535 19 was be VBD cord-005453-4057qib7 12535 20 26.8 26.8 CD cord-005453-4057qib7 12535 21 months month NNS cord-005453-4057qib7 12535 22 . . . cord-005453-4057qib7 12536 1 The the DT cord-005453-4057qib7 12536 2 probabilities probability NNS cord-005453-4057qib7 12536 3 of of IN cord-005453-4057qib7 12536 4 2 2 CD cord-005453-4057qib7 12536 5 years year NNS cord-005453-4057qib7 12536 6 - - : cord-005453-4057qib7 12536 7 PFS PFS NNP cord-005453-4057qib7 12536 8 and and CC cord-005453-4057qib7 12536 9 overall overall JJ cord-005453-4057qib7 12536 10 survival survival NN cord-005453-4057qib7 12536 11 ( ( -LRB- cord-005453-4057qib7 12536 12 OS OS NNP cord-005453-4057qib7 12536 13 ) ) -RRB- cord-005453-4057qib7 12536 14 were be VBD cord-005453-4057qib7 12536 15 56.5 56.5 CD cord-005453-4057qib7 12536 16 % % NN cord-005453-4057qib7 12536 17 and and CC cord-005453-4057qib7 12536 18 not not RB cord-005453-4057qib7 12536 19 estimable estimable JJ cord-005453-4057qib7 12536 20 , , , cord-005453-4057qib7 12536 21 respectively respectively RB cord-005453-4057qib7 12536 22 . . . cord-005453-4057qib7 12537 1 Especially especially RB cord-005453-4057qib7 12537 2 , , , cord-005453-4057qib7 12537 3 high high JJ cord-005453-4057qib7 12537 4 - - HYPH cord-005453-4057qib7 12537 5 risk risk NN cord-005453-4057qib7 12537 6 cytogenetics cytogenetic NNS cord-005453-4057qib7 12537 7 were be VBD cord-005453-4057qib7 12537 8 associated associate VBN cord-005453-4057qib7 12537 9 adverse adverse JJ cord-005453-4057qib7 12537 10 survival survival NN cord-005453-4057qib7 12537 11 outcome outcome NN cord-005453-4057qib7 12537 12 compared compare VBN cord-005453-4057qib7 12537 13 to to IN cord-005453-4057qib7 12537 14 standard standard JJ cord-005453-4057qib7 12537 15 - - HYPH cord-005453-4057qib7 12537 16 risk risk NN cord-005453-4057qib7 12537 17 cytogenetics cytogenetic NNS cord-005453-4057qib7 12537 18 , , , cord-005453-4057qib7 12537 19 respectively respectively RB cord-005453-4057qib7 12537 20 ( ( -LRB- cord-005453-4057qib7 12537 21 PFS PFS NNP cord-005453-4057qib7 12537 22 , , , cord-005453-4057qib7 12537 23 12.2 12.2 CD cord-005453-4057qib7 12537 24 vs. vs. IN cord-005453-4057qib7 12537 25 35.7 35.7 CD cord-005453-4057qib7 12537 26 months month NNS cord-005453-4057qib7 12537 27 , , , cord-005453-4057qib7 12537 28 p=0.039 p=0.039 JJ cord-005453-4057qib7 12537 29 ; ; : cord-005453-4057qib7 12537 30 OS OS NNP cord-005453-4057qib7 12537 31 , , , cord-005453-4057qib7 12537 32 26.7 26.7 CD cord-005453-4057qib7 12537 33 vs. vs. IN cord-005453-4057qib7 12537 34 73.3 73.3 CD cord-005453-4057qib7 12537 35 months month NNS cord-005453-4057qib7 12537 36 , , , cord-005453-4057qib7 12537 37 p=0.086 p=0.086 NNPS cord-005453-4057qib7 12537 38 ) ) -RRB- cord-005453-4057qib7 12537 39 . . . cord-005453-4057qib7 12538 1 With with IN cord-005453-4057qib7 12538 2 median median JJ cord-005453-4057qib7 12538 3 11 11 CD cord-005453-4057qib7 12538 4 days day NNS cord-005453-4057qib7 12538 5 and and CC cord-005453-4057qib7 12538 6 10 10 CD cord-005453-4057qib7 12538 7 days day NNS cord-005453-4057qib7 12538 8 for for IN cord-005453-4057qib7 12538 9 neutrophil neutrophil NN cord-005453-4057qib7 12538 10 and and CC cord-005453-4057qib7 12538 11 platelet platelet NN cord-005453-4057qib7 12538 12 engraftments engraftment NNS cord-005453-4057qib7 12538 13 , , , cord-005453-4057qib7 12538 14 any any DT cord-005453-4057qib7 12538 15 graft graft NN cord-005453-4057qib7 12538 16 failure failure NN cord-005453-4057qib7 12538 17 or or CC cord-005453-4057qib7 12538 18 delayed delay VBN cord-005453-4057qib7 12538 19 engraft engraft NN cord-005453-4057qib7 12538 20 was be VBD cord-005453-4057qib7 12538 21 not not RB cord-005453-4057qib7 12538 22 observed observe VBN cord-005453-4057qib7 12538 23 . . . cord-005453-4057qib7 12539 1 The the DT cord-005453-4057qib7 12539 2 common common JJ cord-005453-4057qib7 12539 3 grade grade NN cord-005453-4057qib7 12539 4 3 3 CD cord-005453-4057qib7 12539 5 or or CC cord-005453-4057qib7 12539 6 severe severe JJ cord-005453-4057qib7 12539 7 non non JJ cord-005453-4057qib7 12539 8 - - JJ cord-005453-4057qib7 12539 9 hematological hematological JJ cord-005453-4057qib7 12539 10 adverse adverse JJ cord-005453-4057qib7 12539 11 events event NNS cord-005453-4057qib7 12539 12 included include VBD cord-005453-4057qib7 12539 13 neutropenic neutropenic JJ cord-005453-4057qib7 12539 14 fever fever NN cord-005453-4057qib7 12539 15 ( ( -LRB- cord-005453-4057qib7 12539 16 73.2 73.2 CD cord-005453-4057qib7 12539 17 % % NN cord-005453-4057qib7 12539 18 ) ) -RRB- cord-005453-4057qib7 12539 19 and and CC cord-005453-4057qib7 12539 20 stomatitis stomatitis NN cord-005453-4057qib7 12539 21 ( ( -LRB- cord-005453-4057qib7 12539 22 14.6 14.6 CD cord-005453-4057qib7 12539 23 % % NN cord-005453-4057qib7 12539 24 ) ) -RRB- cord-005453-4057qib7 12539 25 . . . cord-005453-4057qib7 12540 1 Except except IN cord-005453-4057qib7 12540 2 three three CD cord-005453-4057qib7 12540 3 cases case NNS cord-005453-4057qib7 12540 4 with with IN cord-005453-4057qib7 12540 5 transplant transplant NN cord-005453-4057qib7 12540 6 - - HYPH cord-005453-4057qib7 12540 7 related relate VBN cord-005453-4057qib7 12540 8 mortality mortality NN cord-005453-4057qib7 12540 9 due due IN cord-005453-4057qib7 12540 10 to to IN cord-005453-4057qib7 12540 11 sepsis sepsis NN cord-005453-4057qib7 12540 12 , , , cord-005453-4057qib7 12540 13 other other JJ cord-005453-4057qib7 12540 14 adverse adverse JJ cord-005453-4057qib7 12540 15 events event NNS cord-005453-4057qib7 12540 16 were be VBD cord-005453-4057qib7 12540 17 manageable manageable JJ cord-005453-4057qib7 12540 18 . . . cord-005453-4057qib7 12541 1 Conclusions conclusion NNS cord-005453-4057qib7 12541 2 : : : cord-005453-4057qib7 12542 1 These these DT cord-005453-4057qib7 12542 2 results result NNS cord-005453-4057qib7 12542 3 demonstrate demonstrate VBP cord-005453-4057qib7 12542 4 that that IN cord-005453-4057qib7 12542 5 bortezomib bortezomib NNP cord-005453-4057qib7 12542 6 is be VBZ cord-005453-4057qib7 12542 7 safe safe JJ cord-005453-4057qib7 12542 8 and and CC cord-005453-4057qib7 12542 9 can can MD cord-005453-4057qib7 12542 10 be be VB cord-005453-4057qib7 12542 11 a a DT cord-005453-4057qib7 12542 12 part part NN cord-005453-4057qib7 12542 13 of of IN cord-005453-4057qib7 12542 14 conditioning conditioning NN cord-005453-4057qib7 12542 15 regimen regimen NN cord-005453-4057qib7 12542 16 in in IN cord-005453-4057qib7 12542 17 combination combination NN cord-005453-4057qib7 12542 18 with with IN cord-005453-4057qib7 12542 19 BuMel BuMel NNP cord-005453-4057qib7 12542 20 , , , cord-005453-4057qib7 12542 21 for for IN cord-005453-4057qib7 12542 22 patients patient NNS cord-005453-4057qib7 12542 23 with with IN cord-005453-4057qib7 12542 24 transplanteligible transplanteligible JJ cord-005453-4057qib7 12542 25 multiple multiple JJ cord-005453-4057qib7 12542 26 myeloma myeloma NN cord-005453-4057qib7 12542 27 . . . cord-005453-4057qib7 12543 1 Clinical clinical JJ cord-005453-4057qib7 12543 2 Background background NN cord-005453-4057qib7 12543 3 : : : cord-005453-4057qib7 12544 1 Allogeneic allogeneic IN cord-005453-4057qib7 12544 2 stem stem NN cord-005453-4057qib7 12544 3 - - HYPH cord-005453-4057qib7 12544 4 cell cell NN cord-005453-4057qib7 12544 5 transplantation transplantation NN cord-005453-4057qib7 12544 6 ( ( -LRB- cord-005453-4057qib7 12544 7 allo allo FW cord-005453-4057qib7 12544 8 - - HYPH cord-005453-4057qib7 12544 9 SCT SCT NNP cord-005453-4057qib7 12544 10 ) ) -RRB- cord-005453-4057qib7 12544 11 is be VBZ cord-005453-4057qib7 12544 12 one one CD cord-005453-4057qib7 12544 13 of of IN cord-005453-4057qib7 12544 14 treatment treatment NN cord-005453-4057qib7 12544 15 option option NN cord-005453-4057qib7 12544 16 for for IN cord-005453-4057qib7 12544 17 patients patient NNS cord-005453-4057qib7 12544 18 with with IN cord-005453-4057qib7 12544 19 multiple multiple JJ cord-005453-4057qib7 12544 20 myeloma myeloma NN cord-005453-4057qib7 12544 21 ( ( -LRB- cord-005453-4057qib7 12544 22 MM MM NNP cord-005453-4057qib7 12544 23 ) ) -RRB- cord-005453-4057qib7 12544 24 refractory refractory JJ cord-005453-4057qib7 12544 25 to to IN cord-005453-4057qib7 12544 26 novel novel JJ cord-005453-4057qib7 12544 27 agents agent NNS cord-005453-4057qib7 12544 28 . . . cord-005453-4057qib7 12545 1 The the DT cord-005453-4057qib7 12545 2 reports report NNS cord-005453-4057qib7 12545 3 on on IN cord-005453-4057qib7 12545 4 allo allo NN cord-005453-4057qib7 12545 5 - - HYPH cord-005453-4057qib7 12545 6 SCT SCT NNP cord-005453-4057qib7 12545 7 for for IN cord-005453-4057qib7 12545 8 MM MM NNP cord-005453-4057qib7 12545 9 are be VBP cord-005453-4057qib7 12545 10 limited limited JJ cord-005453-4057qib7 12545 11 and and CC cord-005453-4057qib7 12545 12 it -PRON- PRP cord-005453-4057qib7 12545 13 is be VBZ cord-005453-4057qib7 12545 14 an an DT cord-005453-4057qib7 12545 15 important important JJ cord-005453-4057qib7 12545 16 issue issue NN cord-005453-4057qib7 12545 17 to to TO cord-005453-4057qib7 12545 18 argue argue VB cord-005453-4057qib7 12545 19 appropriate appropriate JJ cord-005453-4057qib7 12545 20 conditioning conditioning NN cord-005453-4057qib7 12545 21 regimens regimen NNS cord-005453-4057qib7 12545 22 and and CC cord-005453-4057qib7 12545 23 stem stem NN cord-005453-4057qib7 12545 24 - - HYPH cord-005453-4057qib7 12545 25 cell cell NN cord-005453-4057qib7 12545 26 sources source NNS cord-005453-4057qib7 12545 27 , , , cord-005453-4057qib7 12545 28 and and CC cord-005453-4057qib7 12545 29 patient patient JJ cord-005453-4057qib7 12545 30 population population NN cord-005453-4057qib7 12545 31 who who WP cord-005453-4057qib7 12545 32 will will MD cord-005453-4057qib7 12545 33 benefit benefit VB cord-005453-4057qib7 12545 34 from from IN cord-005453-4057qib7 12545 35 allo allo NN cord-005453-4057qib7 12545 36 - - HYPH cord-005453-4057qib7 12545 37 SCT SCT NNP cord-005453-4057qib7 12545 38 . . . cord-005453-4057qib7 12546 1 Methods method NNS cord-005453-4057qib7 12546 2 : : : cord-005453-4057qib7 12547 1 We -PRON- PRP cord-005453-4057qib7 12547 2 retrospectively retrospectively RB cord-005453-4057qib7 12547 3 analyzed analyze VBD cord-005453-4057qib7 12547 4 25 25 CD cord-005453-4057qib7 12547 5 consecutive consecutive JJ cord-005453-4057qib7 12547 6 patients patient NNS cord-005453-4057qib7 12547 7 who who WP cord-005453-4057qib7 12547 8 received receive VBD cord-005453-4057qib7 12547 9 allo allo NN cord-005453-4057qib7 12547 10 - - HYPH cord-005453-4057qib7 12547 11 SCT SCT NNP cord-005453-4057qib7 12547 12 for for IN cord-005453-4057qib7 12547 13 relapsed relapsed JJ cord-005453-4057qib7 12547 14 and and CC cord-005453-4057qib7 12547 15 refractory refractory JJ cord-005453-4057qib7 12547 16 multiple multiple JJ cord-005453-4057qib7 12547 17 myeloma myeloma NN cord-005453-4057qib7 12547 18 ( ( -LRB- cord-005453-4057qib7 12547 19 RRMM RRMM NNP cord-005453-4057qib7 12547 20 ) ) -RRB- cord-005453-4057qib7 12547 21 between between IN cord-005453-4057qib7 12547 22 Oct Oct NNP cord-005453-4057qib7 12547 23 2009 2009 CD cord-005453-4057qib7 12547 24 and and CC cord-005453-4057qib7 12547 25 July July NNP cord-005453-4057qib7 12547 26 2018 2018 CD cord-005453-4057qib7 12547 27 at at IN cord-005453-4057qib7 12547 28 Japanese japanese JJ cord-005453-4057qib7 12547 29 Red Red NNP cord-005453-4057qib7 12547 30 Cross Cross NNP cord-005453-4057qib7 12547 31 Medical Medical NNP cord-005453-4057qib7 12547 32 Center Center NNP cord-005453-4057qib7 12547 33 . . . cord-005453-4057qib7 12548 1 Characteristics characteristic NNS cord-005453-4057qib7 12548 2 of of IN cord-005453-4057qib7 12548 3 patients patient NNS cord-005453-4057qib7 12548 4 , , , cord-005453-4057qib7 12548 5 progression progression NN cord-005453-4057qib7 12548 6 - - HYPH cord-005453-4057qib7 12548 7 free free JJ cord-005453-4057qib7 12548 8 survival survival NN cord-005453-4057qib7 12548 9 ( ( -LRB- cord-005453-4057qib7 12548 10 PFS PFS NNP cord-005453-4057qib7 12548 11 ) ) -RRB- cord-005453-4057qib7 12548 12 , , , cord-005453-4057qib7 12548 13 and and CC cord-005453-4057qib7 12548 14 overall overall JJ cord-005453-4057qib7 12548 15 survival survival NN cord-005453-4057qib7 12548 16 ( ( -LRB- cord-005453-4057qib7 12548 17 OS OS NNP cord-005453-4057qib7 12548 18 ) ) -RRB- cord-005453-4057qib7 12548 19 were be VBD cord-005453-4057qib7 12548 20 analyzed analyze VBN cord-005453-4057qib7 12548 21 . . . cord-005453-4057qib7 12549 1 Results result NNS cord-005453-4057qib7 12549 2 : : : cord-005453-4057qib7 12550 1 Median median JJ cord-005453-4057qib7 12550 2 age age NN cord-005453-4057qib7 12550 3 at at IN cord-005453-4057qib7 12550 4 allo allo NN cord-005453-4057qib7 12550 5 - - HYPH cord-005453-4057qib7 12550 6 SCT SCT NNP cord-005453-4057qib7 12550 7 was be VBD cord-005453-4057qib7 12550 8 47 47 CD cord-005453-4057qib7 12550 9 ( ( -LRB- cord-005453-4057qib7 12550 10 range range NNP cord-005453-4057qib7 12550 11 31 31 CD cord-005453-4057qib7 12550 12 - - SYM cord-005453-4057qib7 12550 13 61 61 CD cord-005453-4057qib7 12550 14 ) ) -RRB- cord-005453-4057qib7 12550 15 . . . cord-005453-4057qib7 12551 1 Twelve twelve CD cord-005453-4057qib7 12551 2 patients patient NNS cord-005453-4057qib7 12551 3 were be VBD cord-005453-4057qib7 12551 4 male male JJ cord-005453-4057qib7 12551 5 and and CC cord-005453-4057qib7 12551 6 13 13 CD cord-005453-4057qib7 12551 7 were be VBD cord-005453-4057qib7 12551 8 female female JJ cord-005453-4057qib7 12551 9 . . . cord-005453-4057qib7 12552 1 Myeloma myeloma NN cord-005453-4057qib7 12552 2 type type NN cord-005453-4057qib7 12552 3 were be VBD cord-005453-4057qib7 12552 4 IgG:14 IgG:14 VBN cord-005453-4057qib7 12552 5 , , , cord-005453-4057qib7 12552 6 IgA IgA NNP cord-005453-4057qib7 12552 7 : : : cord-005453-4057qib7 12552 8 3 3 CD cord-005453-4057qib7 12552 9 , , , cord-005453-4057qib7 12552 10 IgD IgD NNP cord-005453-4057qib7 12552 11 : : : cord-005453-4057qib7 12552 12 2 2 CD cord-005453-4057qib7 12552 13 , , , cord-005453-4057qib7 12552 14 and and CC cord-005453-4057qib7 12552 15 Bence Bence NNP cord-005453-4057qib7 12552 16 - - HYPH cord-005453-4057qib7 12552 17 Jones Jones NNP cord-005453-4057qib7 12552 18 : : : cord-005453-4057qib7 12552 19 6 6 CD cord-005453-4057qib7 12552 20 . . . cord-005453-4057qib7 12553 1 Stem stem NN cord-005453-4057qib7 12553 2 - - HYPH cord-005453-4057qib7 12553 3 cell cell NN cord-005453-4057qib7 12553 4 sources source NNS cord-005453-4057qib7 12553 5 were be VBD cord-005453-4057qib7 12553 6 peripheral peripheral JJ cord-005453-4057qib7 12553 7 blood blood NN cord-005453-4057qib7 12553 8 from from IN cord-005453-4057qib7 12553 9 HLAmatched hlamatche VBN cord-005453-4057qib7 12553 10 related related JJ cord-005453-4057qib7 12553 11 donor donor NN cord-005453-4057qib7 12553 12 ( ( -LRB- cord-005453-4057qib7 12553 13 rPBSCT rPBSCT NNP cord-005453-4057qib7 12553 14 ) ) -RRB- cord-005453-4057qib7 12553 15 : : : cord-005453-4057qib7 12553 16 6 6 CD cord-005453-4057qib7 12553 17 , , , cord-005453-4057qib7 12553 18 bone bone NN cord-005453-4057qib7 12553 19 mallow mallow NN cord-005453-4057qib7 12553 20 from from IN cord-005453-4057qib7 12553 21 HLA HLA NNP cord-005453-4057qib7 12553 22 - - HYPH cord-005453-4057qib7 12553 23 matched match VBN cord-005453-4057qib7 12553 24 unrelated unrelated JJ cord-005453-4057qib7 12553 25 donor donor NN cord-005453-4057qib7 12553 26 ( ( -LRB- cord-005453-4057qib7 12553 27 MUD mud NN cord-005453-4057qib7 12553 28 ) ) -RRB- cord-005453-4057qib7 12553 29 : : : cord-005453-4057qib7 12553 30 4 4 CD cord-005453-4057qib7 12553 31 , , , cord-005453-4057qib7 12553 32 bone bone NN cord-005453-4057qib7 12553 33 marrow marrow NN cord-005453-4057qib7 12553 34 from from IN cord-005453-4057qib7 12553 35 HLA HLA NNP cord-005453-4057qib7 12553 36 - - HYPH cord-005453-4057qib7 12553 37 mismatched mismatched JJ cord-005453-4057qib7 12553 38 donor donor NN cord-005453-4057qib7 12553 39 ( ( -LRB- cord-005453-4057qib7 12553 40 MMUD MMUD NNP cord-005453-4057qib7 12553 41 ) ) -RRB- cord-005453-4057qib7 12553 42 : : : cord-005453-4057qib7 12553 43 7 7 CD cord-005453-4057qib7 12553 44 , , , cord-005453-4057qib7 12553 45 and and CC cord-005453-4057qib7 12553 46 cord cord NN cord-005453-4057qib7 12553 47 blood blood NN cord-005453-4057qib7 12553 48 ( ( -LRB- cord-005453-4057qib7 12553 49 CB CB NNP cord-005453-4057qib7 12553 50 ) ) -RRB- cord-005453-4057qib7 12553 51 : : : cord-005453-4057qib7 12554 1 8 8 CD cord-005453-4057qib7 12554 2 . . . cord-005453-4057qib7 12555 1 Twenty twenty CD cord-005453-4057qib7 12555 2 - - HYPH cord-005453-4057qib7 12555 3 three three CD cord-005453-4057qib7 12555 4 of of IN cord-005453-4057qib7 12555 5 25 25 CD cord-005453-4057qib7 12555 6 patients patient NNS cord-005453-4057qib7 12555 7 received receive VBN cord-005453-4057qib7 12555 8 Flu Flu NNP cord-005453-4057qib7 12555 9 / / SYM cord-005453-4057qib7 12555 10 Mel Mel NNP cord-005453-4057qib7 12555 11 - - HYPH cord-005453-4057qib7 12555 12 base base NN cord-005453-4057qib7 12555 13 , , , cord-005453-4057qib7 12555 14 one one CD cord-005453-4057qib7 12555 15 patient patient NN cord-005453-4057qib7 12555 16 received receive VBD cord-005453-4057qib7 12555 17 Bu Bu NNP cord-005453-4057qib7 12555 18 / / SYM cord-005453-4057qib7 12555 19 Mel Mel NNP cord-005453-4057qib7 12555 20 - - HYPH cord-005453-4057qib7 12555 21 based base VBN cord-005453-4057qib7 12555 22 , , , cord-005453-4057qib7 12555 23 and and CC cord-005453-4057qib7 12555 24 one one CD cord-005453-4057qib7 12555 25 patient patient NN cord-005453-4057qib7 12555 26 received receive VBN cord-005453-4057qib7 12555 27 etoposide etoposide JJ cord-005453-4057qib7 12555 28 / / SYM cord-005453-4057qib7 12555 29 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 12555 30 - - HYPH cord-005453-4057qib7 12555 31 based base VBN cord-005453-4057qib7 12555 32 conditioning conditioning NN cord-005453-4057qib7 12555 33 regimens regimen NNS cord-005453-4057qib7 12555 34 . . . cord-005453-4057qib7 12556 1 Twenty twenty CD cord-005453-4057qib7 12556 2 - - HYPH cord-005453-4057qib7 12556 3 two two CD cord-005453-4057qib7 12556 4 patients patient NNS cord-005453-4057qib7 12556 5 who who WP cord-005453-4057qib7 12556 6 transplanted transplant VBD cord-005453-4057qib7 12556 7 after after IN cord-005453-4057qib7 12556 8 2012 2012 CD cord-005453-4057qib7 12556 9 received receive VBD cord-005453-4057qib7 12556 10 8Gy 8gy NN cord-005453-4057qib7 12556 11 of of IN cord-005453-4057qib7 12556 12 total total JJ cord-005453-4057qib7 12556 13 body body NN cord-005453-4057qib7 12556 14 irradiation irradiation NN cord-005453-4057qib7 12556 15 ( ( -LRB- cord-005453-4057qib7 12556 16 TBI TBI NNP cord-005453-4057qib7 12556 17 ) ) -RRB- cord-005453-4057qib7 12556 18 . . . cord-005453-4057qib7 12557 1 Responses response NNS cord-005453-4057qib7 12557 2 before before IN cord-005453-4057qib7 12557 3 allo allo NNP cord-005453-4057qib7 12557 4 - - HYPH cord-005453-4057qib7 12557 5 SCT SCT NNP cord-005453-4057qib7 12557 6 were be VBD cord-005453-4057qib7 12557 7 CR cr NN cord-005453-4057qib7 12557 8 : : : cord-005453-4057qib7 12557 9 8 8 CD cord-005453-4057qib7 12557 10 , , , cord-005453-4057qib7 12557 11 VGPR VGPR NNP cord-005453-4057qib7 12557 12 : : : cord-005453-4057qib7 12557 13 6 6 CD cord-005453-4057qib7 12557 14 , , , cord-005453-4057qib7 12557 15 PR PR NNP cord-005453-4057qib7 12557 16 : : : cord-005453-4057qib7 12557 17 6 6 CD cord-005453-4057qib7 12557 18 , , , cord-005453-4057qib7 12557 19 SD sd NN cord-005453-4057qib7 12557 20 : : : cord-005453-4057qib7 12557 21 5 5 CD cord-005453-4057qib7 12557 22 . . . cord-005453-4057qib7 12558 1 Five five CD cord-005453-4057qib7 12558 2 - - HYPH cord-005453-4057qib7 12558 3 year year NN cord-005453-4057qib7 12558 4 PFS PFS NNP cord-005453-4057qib7 12558 5 was be VBD cord-005453-4057qib7 12558 6 22 22 CD cord-005453-4057qib7 12558 7 % % NN cord-005453-4057qib7 12558 8 ( ( -LRB- cord-005453-4057qib7 12558 9 95%CI 95%ci CD cord-005453-4057qib7 12558 10 : : SYM cord-005453-4057qib7 12558 11 6 6 CD cord-005453-4057qib7 12558 12 - - SYM cord-005453-4057qib7 12558 13 45 45 CD cord-005453-4057qib7 12558 14 ) ) -RRB- cord-005453-4057qib7 12558 15 and and CC cord-005453-4057qib7 12558 16 5-year 5-year CD cord-005453-4057qib7 12558 17 OS OS NNP cord-005453-4057qib7 12558 18 was be VBD cord-005453-4057qib7 12558 19 42 42 CD cord-005453-4057qib7 12558 20 % % NN cord-005453-4057qib7 12558 21 ( ( -LRB- cord-005453-4057qib7 12558 22 95%CI 95%ci CD cord-005453-4057qib7 12558 23 : : : cord-005453-4057qib7 12558 24 16 16 CD cord-005453-4057qib7 12558 25 - - SYM cord-005453-4057qib7 12558 26 66 66 CD cord-005453-4057qib7 12558 27 ) ) -RRB- cord-005453-4057qib7 12558 28 . . . cord-005453-4057qib7 12559 1 Ten ten CD cord-005453-4057qib7 12559 2 patients patient NNS cord-005453-4057qib7 12559 3 died die VBD cord-005453-4057qib7 12559 4 during during IN cord-005453-4057qib7 12559 5 observation observation NN cord-005453-4057qib7 12559 6 period period NN cord-005453-4057qib7 12559 7 and and CC cord-005453-4057qib7 12559 8 causes cause NNS cord-005453-4057qib7 12559 9 of of IN cord-005453-4057qib7 12559 10 death death NN cord-005453-4057qib7 12559 11 were be VBD cord-005453-4057qib7 12559 12 primary primary JJ cord-005453-4057qib7 12559 13 disease disease NN cord-005453-4057qib7 12559 14 : : : cord-005453-4057qib7 12559 15 8 8 CD cord-005453-4057qib7 12559 16 and and CC cord-005453-4057qib7 12559 17 treatment treatment NN cord-005453-4057qib7 12559 18 - - HYPH cord-005453-4057qib7 12559 19 related relate VBN cord-005453-4057qib7 12559 20 mortality mortality NN cord-005453-4057qib7 12559 21 : : : cord-005453-4057qib7 12559 22 2 2 CD cord-005453-4057qib7 12559 23 . . . cord-005453-4057qib7 12560 1 Patients patient NNS cord-005453-4057qib7 12560 2 with with IN cord-005453-4057qib7 12560 3 VGPR VGPR NNP cord-005453-4057qib7 12560 4 or or CC cord-005453-4057qib7 12560 5 better well JJR cord-005453-4057qib7 12560 6 before before IN cord-005453-4057qib7 12560 7 allo allo NNP cord-005453-4057qib7 12560 8 - - HYPH cord-005453-4057qib7 12560 9 SCT SCT NNP cord-005453-4057qib7 12560 10 showed show VBD cord-005453-4057qib7 12560 11 significantly significantly RB cord-005453-4057qib7 12560 12 better well JJR cord-005453-4057qib7 12560 13 PFS PFS NNP cord-005453-4057qib7 12560 14 ( ( -LRB- cord-005453-4057qib7 12560 15 p=0.04 p=0.04 NNP cord-005453-4057qib7 12560 16 ) ) -RRB- cord-005453-4057qib7 12560 17 and and CC cord-005453-4057qib7 12560 18 OS OS NNP cord-005453-4057qib7 12560 19 ( ( -LRB- cord-005453-4057qib7 12560 20 p=0.011 p=0.011 NNP cord-005453-4057qib7 12560 21 ) ) -RRB- cord-005453-4057qib7 12560 22 as as IN cord-005453-4057qib7 12560 23 compared compare VBN cord-005453-4057qib7 12560 24 with with IN cord-005453-4057qib7 12560 25 others other NNS cord-005453-4057qib7 12560 26 . . . cord-005453-4057qib7 12561 1 Female female JJ cord-005453-4057qib7 12561 2 recipients recipient NNS cord-005453-4057qib7 12561 3 showed show VBD cord-005453-4057qib7 12561 4 significantly significantly RB cord-005453-4057qib7 12561 5 better well JJR cord-005453-4057qib7 12561 6 PFS PFS NNP cord-005453-4057qib7 12561 7 ( ( -LRB- cord-005453-4057qib7 12561 8 p=0.0034 p=0.0034 NNP cord-005453-4057qib7 12561 9 ) ) -RRB- cord-005453-4057qib7 12561 10 and and CC cord-005453-4057qib7 12561 11 OS OS NNP cord-005453-4057qib7 12561 12 ( ( -LRB- cord-005453-4057qib7 12561 13 p=0.035 p=0.035 NNP cord-005453-4057qib7 12561 14 ) ) -RRB- cord-005453-4057qib7 12562 1 as as IN cord-005453-4057qib7 12562 2 compared compare VBN cord-005453-4057qib7 12562 3 with with IN cord-005453-4057qib7 12562 4 male male JJ cord-005453-4057qib7 12562 5 recipients recipient NNS cord-005453-4057qib7 12562 6 . . . cord-005453-4057qib7 12563 1 Recipients recipient NNS cord-005453-4057qib7 12563 2 of of IN cord-005453-4057qib7 12563 3 MMUD MMUD NNP cord-005453-4057qib7 12563 4 showed show VBD cord-005453-4057qib7 12563 5 significantly significantly RB cord-005453-4057qib7 12563 6 better well JJR cord-005453-4057qib7 12563 7 PFS PFS NNP cord-005453-4057qib7 12563 8 ( ( -LRB- cord-005453-4057qib7 12563 9 p=0.0034 p=0.0034 NN cord-005453-4057qib7 12563 10 ) ) -RRB- cord-005453-4057qib7 12563 11 . . . cord-005453-4057qib7 12564 1 Among among IN cord-005453-4057qib7 12564 2 15 15 CD cord-005453-4057qib7 12564 3 patients patient NNS cord-005453-4057qib7 12564 4 surviving survive VBG cord-005453-4057qib7 12564 5 , , , cord-005453-4057qib7 12564 6 10 10 CD cord-005453-4057qib7 12564 7 patients patient NNS cord-005453-4057qib7 12564 8 received receive VBD cord-005453-4057qib7 12564 9 treatments treatment NNS cord-005453-4057qib7 12564 10 including include VBG cord-005453-4057qib7 12564 11 maintenance maintenance NN cord-005453-4057qib7 12564 12 therapy therapy NN cord-005453-4057qib7 12564 13 . . . cord-005453-4057qib7 12565 1 Conclusions conclusion NNS cord-005453-4057qib7 12565 2 : : : cord-005453-4057qib7 12566 1 The the DT cord-005453-4057qib7 12566 2 reason reason NN cord-005453-4057qib7 12566 3 for for IN cord-005453-4057qib7 12566 4 better well JJR cord-005453-4057qib7 12566 5 PFS PFS NNP cord-005453-4057qib7 12566 6 and and CC cord-005453-4057qib7 12566 7 OS OS NNP cord-005453-4057qib7 12566 8 in in IN cord-005453-4057qib7 12566 9 female female JJ cord-005453-4057qib7 12566 10 recipients recipient NNS cord-005453-4057qib7 12566 11 is be VBZ cord-005453-4057qib7 12566 12 unknown unknown JJ cord-005453-4057qib7 12566 13 . . . cord-005453-4057qib7 12567 1 It -PRON- PRP cord-005453-4057qib7 12567 2 is be VBZ cord-005453-4057qib7 12567 3 interesting interesting JJ cord-005453-4057qib7 12567 4 that that IN cord-005453-4057qib7 12567 5 recipients recipient NNS cord-005453-4057qib7 12567 6 of of IN cord-005453-4057qib7 12567 7 MMUD MMUD NNP cord-005453-4057qib7 12567 8 showed show VBD cord-005453-4057qib7 12567 9 better well JJR cord-005453-4057qib7 12567 10 PFS PFS NNP cord-005453-4057qib7 12567 11 , , , cord-005453-4057qib7 12567 12 suggesting suggest VBG cord-005453-4057qib7 12567 13 graft graft NN cord-005453-4057qib7 12567 14 - - HYPH cord-005453-4057qib7 12567 15 versusmyeloma versusmyeloma NN cord-005453-4057qib7 12567 16 effects effect NNS cord-005453-4057qib7 12567 17 . . . cord-005453-4057qib7 12568 1 Allo Allo NNP cord-005453-4057qib7 12568 2 - - HYPH cord-005453-4057qib7 12568 3 SCT SCT NNP cord-005453-4057qib7 12568 4 can can MD cord-005453-4057qib7 12568 5 be be VB cord-005453-4057qib7 12568 6 an an DT cord-005453-4057qib7 12568 7 effective effective JJ cord-005453-4057qib7 12568 8 treatment treatment NN cord-005453-4057qib7 12568 9 option option NN cord-005453-4057qib7 12568 10 if if IN cord-005453-4057qib7 12568 11 patients patient NNS cord-005453-4057qib7 12568 12 and and CC cord-005453-4057qib7 12568 13 stem stem NN cord-005453-4057qib7 12568 14 - - HYPH cord-005453-4057qib7 12568 15 cell cell NN cord-005453-4057qib7 12568 16 sources source NNS cord-005453-4057qib7 12568 17 are be VBP cord-005453-4057qib7 12568 18 appropriately appropriately RB cord-005453-4057qib7 12568 19 selected select VBN cord-005453-4057qib7 12568 20 . . . cord-005453-4057qib7 12569 1 Disclosure disclosure NN cord-005453-4057qib7 12569 2 : : : cord-005453-4057qib7 12570 1 authors author NNS cord-005453-4057qib7 12570 2 declare declare VBP cord-005453-4057qib7 12570 3 that that IN cord-005453-4057qib7 12570 4 there there EX cord-005453-4057qib7 12570 5 are be VBP cord-005453-4057qib7 12570 6 no no DT cord-005453-4057qib7 12570 7 conflicts conflict NNS cord-005453-4057qib7 12570 8 of of IN cord-005453-4057qib7 12570 9 interest interest NN cord-005453-4057qib7 12570 10 . . . cord-005453-4057qib7 12571 1 Second second JJ cord-005453-4057qib7 12571 2 autologous autologous JJ cord-005453-4057qib7 12571 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 12571 4 stem stem NN cord-005453-4057qib7 12571 5 cell cell NN cord-005453-4057qib7 12571 6 tranpslant tranpslant NN cord-005453-4057qib7 12571 7 versus versus FW cord-005453-4057qib7 12571 8 chemoimmunotherapy chemoimmunotherapy NNP cord-005453-4057qib7 12571 9 in in IN cord-005453-4057qib7 12571 10 relapsed relapse VBN cord-005453-4057qib7 12571 11 multiple multiple JJ cord-005453-4057qib7 12571 12 myeloma myeloma NN cord-005453-4057qib7 12571 13 after after IN cord-005453-4057qib7 12571 14 first first JJ cord-005453-4057qib7 12571 15 transplantation transplantation NN cord-005453-4057qib7 12571 16 : : : cord-005453-4057qib7 12572 1 Single single JJ cord-005453-4057qib7 12572 2 center center NN cord-005453-4057qib7 12572 3 data datum NNS cord-005453-4057qib7 12572 4 Background background NN cord-005453-4057qib7 12572 5 : : : cord-005453-4057qib7 12573 1 Combination combination NN cord-005453-4057qib7 12573 2 therapy therapy NN cord-005453-4057qib7 12573 3 , , , cord-005453-4057qib7 12573 4 mostly mostly RB cord-005453-4057qib7 12573 5 triple triple JJ cord-005453-4057qib7 12573 6 , , , cord-005453-4057qib7 12573 7 followed follow VBN cord-005453-4057qib7 12573 8 by by IN cord-005453-4057qib7 12573 9 autologous autologous JJ cord-005453-4057qib7 12573 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 12573 11 stem stem NN cord-005453-4057qib7 12573 12 cell cell NN cord-005453-4057qib7 12573 13 transplantation transplantation NN cord-005453-4057qib7 12573 14 ( ( -LRB- cord-005453-4057qib7 12573 15 auto auto NN cord-005453-4057qib7 12573 16 - - HYPH cord-005453-4057qib7 12573 17 HCT HCT NNP cord-005453-4057qib7 12573 18 ) ) -RRB- cord-005453-4057qib7 12573 19 is be VBZ cord-005453-4057qib7 12573 20 widely widely RB cord-005453-4057qib7 12573 21 accepted accept VBN cord-005453-4057qib7 12573 22 as as IN cord-005453-4057qib7 12573 23 the the DT cord-005453-4057qib7 12573 24 first first JJ cord-005453-4057qib7 12573 25 - - HYPH cord-005453-4057qib7 12573 26 line line NN cord-005453-4057qib7 12573 27 standard standard JJ cord-005453-4057qib7 12573 28 therapy therapy NN cord-005453-4057qib7 12573 29 for for IN cord-005453-4057qib7 12573 30 multiple multiple JJ cord-005453-4057qib7 12573 31 myeloma myeloma NN cord-005453-4057qib7 12573 32 ( ( -LRB- cord-005453-4057qib7 12573 33 MM MM NNP cord-005453-4057qib7 12573 34 ) ) -RRB- cord-005453-4057qib7 12573 35 . . . cord-005453-4057qib7 12574 1 Despite despite IN cord-005453-4057qib7 12574 2 the the DT cord-005453-4057qib7 12574 3 availability availability NN cord-005453-4057qib7 12574 4 of of IN cord-005453-4057qib7 12574 5 agents agent NNS cord-005453-4057qib7 12574 6 such such JJ cord-005453-4057qib7 12574 7 as as IN cord-005453-4057qib7 12574 8 new new JJ cord-005453-4057qib7 12574 9 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 12574 10 drugs drug NNS cord-005453-4057qib7 12574 11 ( ( -LRB- cord-005453-4057qib7 12574 12 IMIDs IMIDs NNP cord-005453-4057qib7 12574 13 ) ) -RRB- cord-005453-4057qib7 12574 14 , , , cord-005453-4057qib7 12574 15 proteasome proteasome NN cord-005453-4057qib7 12574 16 inhibitors inhibitor NNS cord-005453-4057qib7 12574 17 ( ( -LRB- cord-005453-4057qib7 12574 18 PIs PIs NNP cord-005453-4057qib7 12574 19 ) ) -RRB- cord-005453-4057qib7 12574 20 , , , cord-005453-4057qib7 12574 21 histone histone NN cord-005453-4057qib7 12574 22 - - HYPH cord-005453-4057qib7 12574 23 deacetylase deacetylase NN cord-005453-4057qib7 12574 24 inhibitors inhibitor NNS cord-005453-4057qib7 12574 25 and and CC cord-005453-4057qib7 12574 26 antibodies antibody NNS cord-005453-4057qib7 12574 27 , , , cord-005453-4057qib7 12574 28 it -PRON- PRP cord-005453-4057qib7 12574 29 is be VBZ cord-005453-4057qib7 12574 30 still still RB cord-005453-4057qib7 12574 31 possible possible JJ cord-005453-4057qib7 12574 32 to to TO cord-005453-4057qib7 12574 33 achieve achieve VB cord-005453-4057qib7 12574 34 longer long JJR cord-005453-4057qib7 12574 35 and and CC cord-005453-4057qib7 12574 36 deeper deep JJR cord-005453-4057qib7 12574 37 responses response NNS cord-005453-4057qib7 12574 38 , , , cord-005453-4057qib7 12574 39 however however RB cord-005453-4057qib7 12574 40 , , , cord-005453-4057qib7 12574 41 multiple multiple JJ cord-005453-4057qib7 12574 42 myeloma myeloma NN cord-005453-4057qib7 12574 43 is be VBZ cord-005453-4057qib7 12574 44 still still RB cord-005453-4057qib7 12574 45 not not RB cord-005453-4057qib7 12574 46 cured cure VBN cord-005453-4057qib7 12574 47 and and CC cord-005453-4057qib7 12574 48 relapse relapse NN cord-005453-4057qib7 12574 49 is be VBZ cord-005453-4057qib7 12574 50 inevitable inevitable JJ cord-005453-4057qib7 12574 51 . . . cord-005453-4057qib7 12575 1 The the DT cord-005453-4057qib7 12575 2 availability availability NN cord-005453-4057qib7 12575 3 of of IN cord-005453-4057qib7 12575 4 these these DT cord-005453-4057qib7 12575 5 novel novel JJ cord-005453-4057qib7 12575 6 agents agent NNS cord-005453-4057qib7 12575 7 has have VBZ cord-005453-4057qib7 12575 8 increased increase VBN cord-005453-4057qib7 12575 9 questions question NNS cord-005453-4057qib7 12575 10 for for IN cord-005453-4057qib7 12575 11 determining determine VBG cord-005453-4057qib7 12575 12 optimal optimal JJ cord-005453-4057qib7 12575 13 treatment treatment NN cord-005453-4057qib7 12575 14 of of IN cord-005453-4057qib7 12575 15 patients patient NNS cord-005453-4057qib7 12575 16 with with IN cord-005453-4057qib7 12575 17 relapse relapse NN cord-005453-4057qib7 12575 18 after after IN cord-005453-4057qib7 12575 19 the the DT cord-005453-4057qib7 12575 20 first first JJ cord-005453-4057qib7 12575 21 auto auto NN cord-005453-4057qib7 12575 22 - - HYPH cord-005453-4057qib7 12575 23 HCT hct NN cord-005453-4057qib7 12575 24 . . . cord-005453-4057qib7 12576 1 Methods method NNS cord-005453-4057qib7 12576 2 : : : cord-005453-4057qib7 12576 3 We -PRON- PRP cord-005453-4057qib7 12576 4 retrospectively retrospectively RB cord-005453-4057qib7 12576 5 analyzed analyze VBD cord-005453-4057qib7 12576 6 60 60 CD cord-005453-4057qib7 12576 7 patients patient NNS cord-005453-4057qib7 12576 8 who who WP cord-005453-4057qib7 12576 9 relapsed relapse VBD cord-005453-4057qib7 12576 10 according accord VBG cord-005453-4057qib7 12576 11 to to IN cord-005453-4057qib7 12576 12 International International NNP cord-005453-4057qib7 12576 13 Myeloma Myeloma NNP cord-005453-4057qib7 12576 14 Working Working NNP cord-005453-4057qib7 12576 15 Group Group NNP cord-005453-4057qib7 12576 16 ( ( -LRB- cord-005453-4057qib7 12576 17 IMWG IMWG NNP cord-005453-4057qib7 12576 18 ) ) -RRB- cord-005453-4057qib7 12576 19 criteria criterion NNS cord-005453-4057qib7 12576 20 after after IN cord-005453-4057qib7 12576 21 1st 1st JJ cord-005453-4057qib7 12576 22 auto auto NN cord-005453-4057qib7 12576 23 - - HYPH cord-005453-4057qib7 12576 24 HCT hct NN cord-005453-4057qib7 12576 25 . . . cord-005453-4057qib7 12577 1 First first JJ cord-005453-4057qib7 12577 2 group group NN cord-005453-4057qib7 12577 3 [ [ -LRB- cord-005453-4057qib7 12577 4 salvage salvage NN cord-005453-4057qib7 12577 5 chemotherapy(CT chemotherapy(CT NNS cord-005453-4057qib7 12577 6 ) ) -RRB- cord-005453-4057qib7 12577 7 ] ] -RRB- cord-005453-4057qib7 12578 1 ( ( -LRB- cord-005453-4057qib7 12578 2 n=27 n=27 NNP cord-005453-4057qib7 12578 3 ) ) -RRB- cord-005453-4057qib7 12578 4 was be VBD cord-005453-4057qib7 12578 5 treated treat VBN cord-005453-4057qib7 12578 6 with with IN cord-005453-4057qib7 12578 7 only only RB cord-005453-4057qib7 12578 8 chemoimmunotherapy chemoimmunotherapy NN cord-005453-4057qib7 12578 9 because because IN cord-005453-4057qib7 12578 10 of of IN cord-005453-4057qib7 12578 11 early early JJ cord-005453-4057qib7 12578 12 relapse relapse NN cord-005453-4057qib7 12578 13 or or CC cord-005453-4057qib7 12578 14 refractory refractory JJ cord-005453-4057qib7 12578 15 first first JJ cord-005453-4057qib7 12578 16 auto auto NN cord-005453-4057qib7 12578 17 - - HYPH cord-005453-4057qib7 12578 18 SCT SCT NNP cord-005453-4057qib7 12578 19 ( ( -LRB- cord-005453-4057qib7 12578 20 within within IN cord-005453-4057qib7 12578 21 6 6 CD cord-005453-4057qib7 12578 22 months month NNS cord-005453-4057qib7 12578 23 ) ) -RRB- cord-005453-4057qib7 12578 24 , , , cord-005453-4057qib7 12578 25 ineligible ineligible JJ cord-005453-4057qib7 12578 26 to to IN cord-005453-4057qib7 12578 27 second second JJ cord-005453-4057qib7 12578 28 transplantation transplantation NN cord-005453-4057qib7 12578 29 because because IN cord-005453-4057qib7 12578 30 of of IN cord-005453-4057qib7 12578 31 co co NN cord-005453-4057qib7 12578 32 - - NN cord-005453-4057qib7 12578 33 morbidity morbidity JJ cord-005453-4057qib7 12578 34 , , , cord-005453-4057qib7 12578 35 unwillingness unwillingness NN cord-005453-4057qib7 12578 36 to to IN cord-005453-4057qib7 12578 37 transplant transplant NN cord-005453-4057qib7 12578 38 . . . cord-005453-4057qib7 12579 1 Second second JJ cord-005453-4057qib7 12579 2 group group NN cord-005453-4057qib7 12579 3 ( ( -LRB- cord-005453-4057qib7 12579 4 n=33 n=33 NN cord-005453-4057qib7 12579 5 ) ) -RRB- cord-005453-4057qib7 12579 6 ( ( -LRB- cord-005453-4057qib7 12579 7 salvage salvage NN cord-005453-4057qib7 12579 8 transplantion transplantion NN cord-005453-4057qib7 12579 9 ) ) -RRB- cord-005453-4057qib7 12579 10 was be VBD cord-005453-4057qib7 12579 11 treated treat VBN cord-005453-4057qib7 12579 12 with with IN cord-005453-4057qib7 12579 13 second second JJ cord-005453-4057qib7 12579 14 auto auto NN cord-005453-4057qib7 12579 15 - - HYPH cord-005453-4057qib7 12579 16 HCT hct NN cord-005453-4057qib7 12579 17 as as IN cord-005453-4057qib7 12579 18 a a DT cord-005453-4057qib7 12579 19 salvage salvage NN cord-005453-4057qib7 12579 20 therapy therapy NN cord-005453-4057qib7 12579 21 . . . cord-005453-4057qib7 12580 1 Consolidation consolidation NN cord-005453-4057qib7 12580 2 and and CC cord-005453-4057qib7 12580 3 long long JJ cord-005453-4057qib7 12580 4 term term NN cord-005453-4057qib7 12580 5 maintenance maintenance NN cord-005453-4057qib7 12580 6 treatments treatment NNS cord-005453-4057qib7 12580 7 were be VBD cord-005453-4057qib7 12580 8 used use VBN cord-005453-4057qib7 12580 9 in in IN cord-005453-4057qib7 12580 10 both both DT cord-005453-4057qib7 12580 11 groups group NNS cord-005453-4057qib7 12580 12 . . . cord-005453-4057qib7 12581 1 Results result NNS cord-005453-4057qib7 12581 2 : : : cord-005453-4057qib7 12582 1 There there EX cord-005453-4057qib7 12582 2 was be VBD cord-005453-4057qib7 12582 3 no no DT cord-005453-4057qib7 12582 4 difference difference NN cord-005453-4057qib7 12582 5 in in IN cord-005453-4057qib7 12582 6 sex sex NN cord-005453-4057qib7 12582 7 and and CC cord-005453-4057qib7 12582 8 age age NN cord-005453-4057qib7 12582 9 between between IN cord-005453-4057qib7 12582 10 salvage salvage NN cord-005453-4057qib7 12582 11 CT CT NNP cord-005453-4057qib7 12582 12 and and CC cord-005453-4057qib7 12582 13 auto auto NN cord-005453-4057qib7 12582 14 - - HYPH cord-005453-4057qib7 12582 15 SCT SCT NNP cord-005453-4057qib7 12582 16 groups group NNS cord-005453-4057qib7 12583 1 [ [ -LRB- cord-005453-4057qib7 12583 2 Female female JJ cord-005453-4057qib7 12583 3 / / SYM cord-005453-4057qib7 12583 4 male male NN cord-005453-4057qib7 12583 5 : : . cord-005453-4057qib7 12584 1 11 11 CD cord-005453-4057qib7 12584 2 vs vs IN cord-005453-4057qib7 12584 3 13/ 13/ CD cord-005453-4057qib7 12584 4 16 16 CD cord-005453-4057qib7 12584 5 vs vs IN cord-005453-4057qib7 12584 6 20 20 CD cord-005453-4057qib7 12584 7 ; ; , cord-005453-4057qib7 12584 8 ] ] -RRB- cord-005453-4057qib7 12584 9 . . . cord-005453-4057qib7 12585 1 The the DT cord-005453-4057qib7 12585 2 best good JJS cord-005453-4057qib7 12585 3 response response NN cord-005453-4057qib7 12585 4 after after IN cord-005453-4057qib7 12585 5 salvage salvage NN cord-005453-4057qib7 12585 6 auto auto NN cord-005453-4057qib7 12585 7 - - HYPH cord-005453-4057qib7 12585 8 SCT SCT NNP cord-005453-4057qib7 12585 9 was be VBD cord-005453-4057qib7 12585 10 complete complete JJ cord-005453-4057qib7 12585 11 remission remission NN cord-005453-4057qib7 12585 12 ( ( -LRB- cord-005453-4057qib7 12585 13 CR CR NNP cord-005453-4057qib7 12585 14 ) ) -RRB- cord-005453-4057qib7 12585 15 in in IN cord-005453-4057qib7 12585 16 62,5 62,5 CD cord-005453-4057qib7 12585 17 % % NN cord-005453-4057qib7 12585 18 , , , cord-005453-4057qib7 12585 19 partial partial JJ cord-005453-4057qib7 12585 20 remission remission NN cord-005453-4057qib7 12585 21 ( ( -LRB- cord-005453-4057qib7 12585 22 PR PR NNP cord-005453-4057qib7 12585 23 ) ) -RRB- cord-005453-4057qib7 12585 24 in in IN cord-005453-4057qib7 12585 25 15,6 15,6 CD cord-005453-4057qib7 12585 26 % % NN cord-005453-4057qib7 12585 27 patients patient NNS cord-005453-4057qib7 12585 28 , , , cord-005453-4057qib7 12585 29 while while IN cord-005453-4057qib7 12585 30 CR CR NNP cord-005453-4057qib7 12585 31 in in IN cord-005453-4057qib7 12585 32 44 44 CD cord-005453-4057qib7 12585 33 % % NN cord-005453-4057qib7 12585 34 , , , cord-005453-4057qib7 12585 35 PR PR NNP cord-005453-4057qib7 12585 36 in in IN cord-005453-4057qib7 12585 37 14,8 14,8 CD cord-005453-4057qib7 12585 38 % % NN cord-005453-4057qib7 12585 39 patients patient NNS cord-005453-4057qib7 12585 40 treated treat VBN cord-005453-4057qib7 12585 41 with with IN cord-005453-4057qib7 12585 42 salvage salvage NN cord-005453-4057qib7 12585 43 CT CT NNP cord-005453-4057qib7 12585 44 . . . cord-005453-4057qib7 12586 1 Progression progression NN cord-005453-4057qib7 12586 2 free free JJ cord-005453-4057qib7 12586 3 survival survival NN cord-005453-4057qib7 12586 4 ( ( -LRB- cord-005453-4057qib7 12586 5 PFS PFS NNP cord-005453-4057qib7 12586 6 ) ) -RRB- cord-005453-4057qib7 12586 7 were be VBD cord-005453-4057qib7 12586 8 significantly significantly RB cord-005453-4057qib7 12586 9 better well JJR cord-005453-4057qib7 12586 10 in in IN cord-005453-4057qib7 12586 11 second second JJ cord-005453-4057qib7 12586 12 transplant transplant NN cord-005453-4057qib7 12586 13 group group NN cord-005453-4057qib7 12586 14 ( ( -LRB- cord-005453-4057qib7 12586 15 PFS PFS NNP cord-005453-4057qib7 12586 16 ; ; : cord-005453-4057qib7 12586 17 71 71 CD cord-005453-4057qib7 12586 18 % % NN cord-005453-4057qib7 12586 19 on on IN cord-005453-4057qib7 12586 20 the the DT cord-005453-4057qib7 12586 21 first first JJ cord-005453-4057qib7 12586 22 year year NN cord-005453-4057qib7 12586 23 ; ; : cord-005453-4057qib7 12586 24 46,9 46,9 CD cord-005453-4057qib7 12586 25 % % NN cord-005453-4057qib7 12586 26 on on IN cord-005453-4057qib7 12586 27 the the DT cord-005453-4057qib7 12586 28 second second JJ cord-005453-4057qib7 12586 29 year year NN cord-005453-4057qib7 12586 30 after after IN cord-005453-4057qib7 12586 31 transplant transplant NN cord-005453-4057qib7 12586 32 vs vs IN cord-005453-4057qib7 12586 33 59 59 CD cord-005453-4057qib7 12586 34 % % NN cord-005453-4057qib7 12586 35 on on IN cord-005453-4057qib7 12586 36 the the DT cord-005453-4057qib7 12586 37 first first JJ cord-005453-4057qib7 12586 38 year year NN cord-005453-4057qib7 12586 39 ; ; : cord-005453-4057qib7 12586 40 17 17 CD cord-005453-4057qib7 12586 41 % % NN cord-005453-4057qib7 12586 42 on on IN cord-005453-4057qib7 12586 43 the the DT cord-005453-4057qib7 12586 44 second second JJ cord-005453-4057qib7 12586 45 year year NN cord-005453-4057qib7 12586 46 after after IN cord-005453-4057qib7 12586 47 the the DT cord-005453-4057qib7 12586 48 salvage salvage NN cord-005453-4057qib7 12586 49 therapy therapy NN cord-005453-4057qib7 12586 50 in in IN cord-005453-4057qib7 12586 51 chemotherapy chemotherapy NN cord-005453-4057qib7 12586 52 patients)[p patients)[p CD cord-005453-4057qib7 12586 53 : : : cord-005453-4057qib7 12586 54 0,001 0,001 CD cord-005453-4057qib7 12586 55 ] ] -RRB- cord-005453-4057qib7 12586 56 . . . cord-005453-4057qib7 12587 1 Overall overall JJ cord-005453-4057qib7 12587 2 survival survival NN cord-005453-4057qib7 12587 3 ( ( -LRB- cord-005453-4057qib7 12587 4 OS OS NNP cord-005453-4057qib7 12587 5 ) ) -RRB- cord-005453-4057qib7 12587 6 in in IN cord-005453-4057qib7 12587 7 salvage salvage NN cord-005453-4057qib7 12587 8 auto auto NN cord-005453-4057qib7 12587 9 - - HYPH cord-005453-4057qib7 12587 10 SCT SCT NNP cord-005453-4057qib7 12587 11 group group NN cord-005453-4057qib7 12587 12 was be VBD cord-005453-4057qib7 12587 13 longer long JJR cord-005453-4057qib7 12587 14 than than IN cord-005453-4057qib7 12587 15 salvage salvage VB cord-005453-4057qib7 12587 16 CT CT NNP cord-005453-4057qib7 12587 17 ( ( -LRB- cord-005453-4057qib7 12588 1 42,3 42,3 CD cord-005453-4057qib7 12588 2 % % NN cord-005453-4057qib7 12588 3 23.7 23.7 CD cord-005453-4057qib7 12588 4 % % NN cord-005453-4057qib7 12588 5 ) ) -RRB- cord-005453-4057qib7 12588 6 , , , cord-005453-4057qib7 12588 7 although although IN cord-005453-4057qib7 12588 8 it -PRON- PRP cord-005453-4057qib7 12588 9 did do VBD cord-005453-4057qib7 12588 10 not not RB cord-005453-4057qib7 12588 11 reach reach VB cord-005453-4057qib7 12588 12 a a DT cord-005453-4057qib7 12588 13 statistical statistical JJ cord-005453-4057qib7 12588 14 significance significance NN cord-005453-4057qib7 12588 15 ( ( -LRB- cord-005453-4057qib7 12588 16 p>0.05 p>0.05 NNP cord-005453-4057qib7 12588 17 ) ) -RRB- cord-005453-4057qib7 12588 18 . . . cord-005453-4057qib7 12589 1 Time time NN cord-005453-4057qib7 12589 2 to to IN cord-005453-4057qib7 12589 3 achieving achieve VBG cord-005453-4057qib7 12589 4 the the DT cord-005453-4057qib7 12589 5 best good JJS cord-005453-4057qib7 12589 6 response response NN cord-005453-4057qib7 12589 7 after after IN cord-005453-4057qib7 12589 8 salvage salvage NN cord-005453-4057qib7 12589 9 auto auto NN cord-005453-4057qib7 12589 10 - - HYPH cord-005453-4057qib7 12589 11 SCT sct NN cord-005453-4057qib7 12589 12 and and CC cord-005453-4057qib7 12589 13 salvage salvage NN cord-005453-4057qib7 12589 14 CT CT NNP cord-005453-4057qib7 12589 15 was be VBD cord-005453-4057qib7 12589 16 1 1 CD cord-005453-4057qib7 12589 17 ( ( -LRB- cord-005453-4057qib7 12589 18 0 0 CD cord-005453-4057qib7 12589 19 - - SYM cord-005453-4057qib7 12589 20 9 9 CD cord-005453-4057qib7 12589 21 ) ) -RRB- cord-005453-4057qib7 12589 22 month month NN cord-005453-4057qib7 12589 23 versus versus IN cord-005453-4057qib7 12589 24 6,5(2 6,5(2 NNP cord-005453-4057qib7 12589 25 - - SYM cord-005453-4057qib7 12589 26 15 15 CD cord-005453-4057qib7 12589 27 ) ) -RRB- cord-005453-4057qib7 12589 28 months month NNS cord-005453-4057qib7 12589 29 [ [ -LRB- cord-005453-4057qib7 12589 30 p:0,02 p:0,02 NN cord-005453-4057qib7 12589 31 ] ] -RRB- cord-005453-4057qib7 12589 32 . . . cord-005453-4057qib7 12590 1 Grade grade NN cord-005453-4057qib7 12590 2 3 3 CD cord-005453-4057qib7 12590 3 or or CC cord-005453-4057qib7 12590 4 4 4 CD cord-005453-4057qib7 12590 5 nonhematological nonhematological JJ cord-005453-4057qib7 12590 6 toxicities toxicity NNS cord-005453-4057qib7 12590 7 were be VBD cord-005453-4057qib7 12590 8 similar similar JJ cord-005453-4057qib7 12590 9 ( ( -LRB- cord-005453-4057qib7 12590 10 auto auto NN cord-005453-4057qib7 12590 11 - - HYPH cord-005453-4057qib7 12590 12 SCT SCT NNP cord-005453-4057qib7 12590 13 19 19 CD cord-005453-4057qib7 12590 14 % % NN cord-005453-4057qib7 12590 15 , , , cord-005453-4057qib7 12590 16 salvage salvage NN cord-005453-4057qib7 12590 17 CT CT NNP cord-005453-4057qib7 12590 18 13 13 CD cord-005453-4057qib7 12590 19 % % NN cord-005453-4057qib7 12590 20 ) ) -RRB- cord-005453-4057qib7 12590 21 in in IN cord-005453-4057qib7 12590 22 both both DT cord-005453-4057qib7 12590 23 groups group NNS cord-005453-4057qib7 12590 24 . . . cord-005453-4057qib7 12591 1 Conclusions conclusion NNS cord-005453-4057qib7 12591 2 : : : cord-005453-4057qib7 12592 1 Salvage salvage NN cord-005453-4057qib7 12592 2 auto auto NN cord-005453-4057qib7 12592 3 - - HYPH cord-005453-4057qib7 12592 4 HCT HCT NNP cord-005453-4057qib7 12592 5 may may MD cord-005453-4057qib7 12592 6 provides provide VBZ cord-005453-4057qib7 12592 7 longer long JJR cord-005453-4057qib7 12592 8 progression progression NN cord-005453-4057qib7 12592 9 free free JJ cord-005453-4057qib7 12592 10 survival survival NN cord-005453-4057qib7 12592 11 with with IN cord-005453-4057qib7 12592 12 similar similar JJ cord-005453-4057qib7 12592 13 toxicity toxicity NN cord-005453-4057qib7 12592 14 profile profile NN cord-005453-4057qib7 12592 15 according accord VBG cord-005453-4057qib7 12592 16 to to IN cord-005453-4057qib7 12592 17 chemoimmunotherapy chemoimmunotherapy NNP cord-005453-4057qib7 12592 18 especially especially RB cord-005453-4057qib7 12592 19 in in IN cord-005453-4057qib7 12592 20 patients patient NNS cord-005453-4057qib7 12592 21 with with IN cord-005453-4057qib7 12592 22 sensitive sensitive JJ cord-005453-4057qib7 12592 23 to to IN cord-005453-4057qib7 12592 24 first first JJ cord-005453-4057qib7 12592 25 auto auto NN cord-005453-4057qib7 12592 26 - - HYPH cord-005453-4057qib7 12592 27 SCT SCT NNP cord-005453-4057qib7 12592 28 . . . cord-005453-4057qib7 12593 1 It -PRON- PRP cord-005453-4057qib7 12593 2 is be VBZ cord-005453-4057qib7 12593 3 suggested suggest VBN cord-005453-4057qib7 12593 4 that that IN cord-005453-4057qib7 12593 5 earlier early JJR cord-005453-4057qib7 12593 6 and and CC cord-005453-4057qib7 12593 7 better well JJR cord-005453-4057qib7 12593 8 responses response NNS cord-005453-4057qib7 12593 9 , , , cord-005453-4057qib7 12593 10 long long JJ cord-005453-4057qib7 12593 11 - - HYPH cord-005453-4057qib7 12593 12 term term NN cord-005453-4057qib7 12593 13 progression progression NN cord-005453-4057qib7 12593 14 free free JJ cord-005453-4057qib7 12593 15 survival survival NN cord-005453-4057qib7 12593 16 can can MD cord-005453-4057qib7 12593 17 be be VB cord-005453-4057qib7 12593 18 achieved achieve VBN cord-005453-4057qib7 12593 19 with with IN cord-005453-4057qib7 12593 20 salvage salvage NN cord-005453-4057qib7 12593 21 auto auto NN cord-005453-4057qib7 12593 22 - - HYPH cord-005453-4057qib7 12593 23 SCT SCT NNP cord-005453-4057qib7 12593 24 . . . cord-005453-4057qib7 12594 1 We -PRON- PRP cord-005453-4057qib7 12594 2 believe believe VBP cord-005453-4057qib7 12594 3 that that IN cord-005453-4057qib7 12594 4 there there EX cord-005453-4057qib7 12594 5 will will MD cord-005453-4057qib7 12594 6 be be VB cord-005453-4057qib7 12594 7 statistical statistical JJ cord-005453-4057qib7 12594 8 significance significance NN cord-005453-4057qib7 12594 9 in in IN cord-005453-4057qib7 12594 10 OS OS NNP cord-005453-4057qib7 12594 11 such such JJ cord-005453-4057qib7 12594 12 as as IN cord-005453-4057qib7 12594 13 PFS PFS NNP cord-005453-4057qib7 12594 14 by by IN cord-005453-4057qib7 12594 15 increasing increase VBG cord-005453-4057qib7 12594 16 the the DT cord-005453-4057qib7 12594 17 number number NN cord-005453-4057qib7 12594 18 of of IN cord-005453-4057qib7 12594 19 patients patient NNS cord-005453-4057qib7 12594 20 . . . cord-005453-4057qib7 12595 1 The the DT cord-005453-4057qib7 12595 2 authors author NNS cord-005453-4057qib7 12595 3 believe believe VBP cord-005453-4057qib7 12595 4 that that IN cord-005453-4057qib7 12595 5 large large JJ cord-005453-4057qib7 12595 6 scale scale NN cord-005453-4057qib7 12595 7 randomized randomize VBN cord-005453-4057qib7 12595 8 clinical clinical JJ cord-005453-4057qib7 12595 9 trials trial NNS cord-005453-4057qib7 12595 10 are be VBP cord-005453-4057qib7 12595 11 needed need VBN cord-005453-4057qib7 12595 12 for for IN cord-005453-4057qib7 12595 13 optimal optimal JJ cord-005453-4057qib7 12595 14 treatment treatment NN cord-005453-4057qib7 12595 15 of of IN cord-005453-4057qib7 12595 16 relapsing relapse VBG cord-005453-4057qib7 12595 17 multiple multiple JJ cord-005453-4057qib7 12595 18 myeloma myeloma NN cord-005453-4057qib7 12595 19 after after IN cord-005453-4057qib7 12595 20 first first JJ cord-005453-4057qib7 12595 21 auto auto NN cord-005453-4057qib7 12595 22 - - HYPH cord-005453-4057qib7 12595 23 SCT SCT NNP cord-005453-4057qib7 12595 24 . . . cord-005453-4057qib7 12596 1 Disclosure disclosure NN cord-005453-4057qib7 12596 2 : : : cord-005453-4057qib7 12596 3 Nothing nothing NN cord-005453-4057qib7 12596 4 to to TO cord-005453-4057qib7 12596 5 declare declare VB cord-005453-4057qib7 12596 6 Background background NN cord-005453-4057qib7 12596 7 : : : cord-005453-4057qib7 12597 1 One one CD cord-005453-4057qib7 12597 2 of of IN cord-005453-4057qib7 12597 3 the the DT cord-005453-4057qib7 12597 4 conditions condition NNS cord-005453-4057qib7 12597 5 for for IN cord-005453-4057qib7 12597 6 successful successful JJ cord-005453-4057qib7 12597 7 transplantation transplantation NN cord-005453-4057qib7 12597 8 of of IN cord-005453-4057qib7 12597 9 autologous autologous JJ cord-005453-4057qib7 12597 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 12597 11 stem stem NN cord-005453-4057qib7 12597 12 cells cell NNS cord-005453-4057qib7 12597 13 ( ( -LRB- cord-005453-4057qib7 12597 14 auto auto NN cord-005453-4057qib7 12597 15 - - HYPH cord-005453-4057qib7 12597 16 HSCT HSCT NNP cord-005453-4057qib7 12597 17 ) ) -RRB- cord-005453-4057qib7 12597 18 in in IN cord-005453-4057qib7 12597 19 patients patient NNS cord-005453-4057qib7 12597 20 with with IN cord-005453-4057qib7 12597 21 multiple multiple JJ cord-005453-4057qib7 12597 22 myeloma myeloma NN cord-005453-4057qib7 12597 23 ( ( -LRB- cord-005453-4057qib7 12597 24 MM MM NNP cord-005453-4057qib7 12597 25 ) ) -RRB- cord-005453-4057qib7 12597 26 is be VBZ cord-005453-4057qib7 12597 27 the the DT cord-005453-4057qib7 12597 28 timely timely JJ cord-005453-4057qib7 12597 29 recovery recovery NN cord-005453-4057qib7 12597 30 of of IN cord-005453-4057qib7 12597 31 hematopoiesis hematopoiesis NN cord-005453-4057qib7 12597 32 , , , cord-005453-4057qib7 12597 33 which which WDT cord-005453-4057qib7 12597 34 is be VBZ cord-005453-4057qib7 12597 35 associated associate VBN cord-005453-4057qib7 12597 36 with with IN cord-005453-4057qib7 12597 37 the the DT cord-005453-4057qib7 12597 38 quantitative quantitative JJ cord-005453-4057qib7 12597 39 and and CC cord-005453-4057qib7 12597 40 qualitative qualitative JJ cord-005453-4057qib7 12597 41 characteristics characteristic NNS cord-005453-4057qib7 12597 42 of of IN cord-005453-4057qib7 12597 43 the the DT cord-005453-4057qib7 12597 44 graft graft NN cord-005453-4057qib7 12597 45 . . . cord-005453-4057qib7 12598 1 One one CD cord-005453-4057qib7 12598 2 of of IN cord-005453-4057qib7 12598 3 the the DT cord-005453-4057qib7 12598 4 key key JJ cord-005453-4057qib7 12598 5 indicators indicator NNS cord-005453-4057qib7 12598 6 is be VBZ cord-005453-4057qib7 12598 7 the the DT cord-005453-4057qib7 12598 8 content content NN cord-005453-4057qib7 12598 9 of of IN cord-005453-4057qib7 12598 10 CD34 CD34 NNP cord-005453-4057qib7 12598 11 + + CC cord-005453-4057qib7 12598 12 cells cell NNS cord-005453-4057qib7 12598 13 in in IN cord-005453-4057qib7 12598 14 the the DT cord-005453-4057qib7 12598 15 autograft autograft NN cord-005453-4057qib7 12598 16 , , , cord-005453-4057qib7 12598 17 which which WDT cord-005453-4057qib7 12598 18 depends depend VBZ cord-005453-4057qib7 12598 19 on on IN cord-005453-4057qib7 12598 20 many many JJ cord-005453-4057qib7 12598 21 factors factor NNS cord-005453-4057qib7 12598 22 . . . cord-005453-4057qib7 12599 1 Some some DT cord-005453-4057qib7 12599 2 of of IN cord-005453-4057qib7 12599 3 them -PRON- PRP cord-005453-4057qib7 12599 4 are be VBP cord-005453-4057qib7 12599 5 due due JJ cord-005453-4057qib7 12599 6 to to IN cord-005453-4057qib7 12599 7 previous previous JJ cord-005453-4057qib7 12599 8 treatment treatment NN cord-005453-4057qib7 12599 9 , , , cord-005453-4057qib7 12599 10 others other NNS cord-005453-4057qib7 12599 11 are be VBP cord-005453-4057qib7 12599 12 directly directly RB cord-005453-4057qib7 12599 13 related relate VBN cord-005453-4057qib7 12599 14 to to IN cord-005453-4057qib7 12599 15 the the DT cord-005453-4057qib7 12599 16 patient patient NN cord-005453-4057qib7 12599 17 : : : cord-005453-4057qib7 12599 18 age age NN cord-005453-4057qib7 12599 19 , , , cord-005453-4057qib7 12599 20 stage stage NN cord-005453-4057qib7 12599 21 of of IN cord-005453-4057qib7 12599 22 the the DT cord-005453-4057qib7 12599 23 disease disease NN cord-005453-4057qib7 12599 24 , , , cord-005453-4057qib7 12599 25 features feature NNS cord-005453-4057qib7 12599 26 of of IN cord-005453-4057qib7 12599 27 the the DT cord-005453-4057qib7 12599 28 hematopoietic hematopoietic JJ cord-005453-4057qib7 12599 29 stem stem NN cord-005453-4057qib7 12599 30 cells cell NNS cord-005453-4057qib7 12599 31 ( ( -LRB- cord-005453-4057qib7 12599 32 HSC HSC NNP cord-005453-4057qib7 12599 33 ) ) -RRB- cord-005453-4057qib7 12599 34 microenvironment microenvironment NN cord-005453-4057qib7 12599 35 . . . cord-005453-4057qib7 12600 1 The the DT cord-005453-4057qib7 12600 2 aim aim NN cord-005453-4057qib7 12600 3 of of IN cord-005453-4057qib7 12600 4 the the DT cord-005453-4057qib7 12600 5 study study NN cord-005453-4057qib7 12600 6 was be VBD cord-005453-4057qib7 12600 7 to to TO cord-005453-4057qib7 12600 8 assess assess VB cord-005453-4057qib7 12600 9 the the DT cord-005453-4057qib7 12600 10 influence influence NN cord-005453-4057qib7 12600 11 of of IN cord-005453-4057qib7 12600 12 the the DT cord-005453-4057qib7 12600 13 immune immune JJ cord-005453-4057qib7 12600 14 response response NN cord-005453-4057qib7 12600 15 genes gene NNS cord-005453-4057qib7 12600 16 on on IN cord-005453-4057qib7 12600 17 the the DT cord-005453-4057qib7 12600 18 autograft autograft NN cord-005453-4057qib7 12600 19 cellularity cellularity NN cord-005453-4057qib7 12600 20 in in IN cord-005453-4057qib7 12600 21 patients patient NNS cord-005453-4057qib7 12600 22 with with IN cord-005453-4057qib7 12600 23 MM MM NNP cord-005453-4057qib7 12600 24 . . . cord-005453-4057qib7 12601 1 Methods method NNS cord-005453-4057qib7 12601 2 : : : cord-005453-4057qib7 12601 3 А а JJ cord-005453-4057qib7 12601 4 retrospective retrospective JJ cord-005453-4057qib7 12601 5 analysis analysis NN cord-005453-4057qib7 12601 6 of of IN cord-005453-4057qib7 12601 7 the the DT cord-005453-4057qib7 12601 8 genotyping genotyping NN cord-005453-4057qib7 12601 9 results result NNS cord-005453-4057qib7 12601 10 was be VBD cord-005453-4057qib7 12601 11 performed perform VBN cord-005453-4057qib7 12601 12 . . . cord-005453-4057qib7 12602 1 Evaluation evaluation NN cord-005453-4057qib7 12602 2 of of IN cord-005453-4057qib7 12602 3 21 21 CD cord-005453-4057qib7 12602 4 loci locus NNS cord-005453-4057qib7 12602 5 in in IN cord-005453-4057qib7 12602 6 15 15 CD cord-005453-4057qib7 12602 7 genes gene NNS cord-005453-4057qib7 12602 8 immune immune VBP cord-005453-4057qib7 12602 9 response response NN cord-005453-4057qib7 12602 10 and and CC cord-005453-4057qib7 12602 11 harvesting harvesting NN cord-005453-4057qib7 12602 12 of of IN cord-005453-4057qib7 12602 13 autologous autologous JJ cord-005453-4057qib7 12602 14 HSC HSC NNP cord-005453-4057qib7 12602 15 in in IN cord-005453-4057qib7 12602 16 78 78 CD cord-005453-4057qib7 12602 17 patients patient NNS cord-005453-4057qib7 12602 18 with with IN cord-005453-4057qib7 12602 19 MM MM NNP cord-005453-4057qib7 12602 20 has have VBZ cord-005453-4057qib7 12602 21 been be VBN cord-005453-4057qib7 12602 22 made make VBN cord-005453-4057qib7 12602 23 . . . cord-005453-4057qib7 12603 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 12603 2 stem stem NN cord-005453-4057qib7 12603 3 cell cell NN cord-005453-4057qib7 12603 4 mobilization mobilization NN cord-005453-4057qib7 12603 5 regimen regimen NN cord-005453-4057qib7 12603 6 included include VBD cord-005453-4057qib7 12603 7 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12603 8 4 4 CD cord-005453-4057qib7 12603 9 g g NN cord-005453-4057qib7 12603 10 / / SYM cord-005453-4057qib7 12603 11 m m NN cord-005453-4057qib7 12603 12 2 2 CD cord-005453-4057qib7 12603 13 with with IN cord-005453-4057qib7 12603 14 granulocyte granulocyte NN cord-005453-4057qib7 12603 15 colony colony NN cord-005453-4057qib7 12603 16 - - HYPH cord-005453-4057qib7 12603 17 stimulating stimulate VBG cord-005453-4057qib7 12603 18 factor factor NN cord-005453-4057qib7 12603 19 . . . cord-005453-4057qib7 12604 1 Genotyping genotype VBG cord-005453-4057qib7 12604 2 of of IN cord-005453-4057qib7 12604 3 the the DT cord-005453-4057qib7 12604 4 immune immune JJ cord-005453-4057qib7 12604 5 response response NN cord-005453-4057qib7 12604 6 genes gene NNS cord-005453-4057qib7 12604 7 polymorphic polymorphic JJ cord-005453-4057qib7 12604 8 regions region NNS cord-005453-4057qib7 12604 9 was be VBD cord-005453-4057qib7 12604 10 carried carry VBN cord-005453-4057qib7 12604 11 out out RP cord-005453-4057qib7 12604 12 by by IN cord-005453-4057qib7 12604 13 the the DT cord-005453-4057qib7 12604 14 polymerase polymerase NN cord-005453-4057qib7 12604 15 chain chain NN cord-005453-4057qib7 12604 16 reaction reaction NN cord-005453-4057qib7 12604 17 with with IN cord-005453-4057qib7 12604 18 allelespecific allelespecific JJ cord-005453-4057qib7 12604 19 primers primer NNS cord-005453-4057qib7 12604 20 . . . cord-005453-4057qib7 12605 1 The the DT cord-005453-4057qib7 12605 2 number number NN cord-005453-4057qib7 12605 3 of of IN cord-005453-4057qib7 12605 4 CD34 CD34 NNP cord-005453-4057qib7 12605 5 + + CC cord-005453-4057qib7 12605 6 cells cell NNS cord-005453-4057qib7 12605 7 was be VBD cord-005453-4057qib7 12605 8 counted count VBN cord-005453-4057qib7 12605 9 on on IN cord-005453-4057qib7 12605 10 a a DT cord-005453-4057qib7 12605 11 6-color 6-color CD cord-005453-4057qib7 12605 12 FACS FACS NNP cord-005453-4057qib7 12605 13 Canto Canto NNP cord-005453-4057qib7 12605 14 II II NNP cord-005453-4057qib7 12605 15 flow flow NN cord-005453-4057qib7 12605 16 cytometer cytometer NN cord-005453-4057qib7 12605 17 . . . cord-005453-4057qib7 12606 1 Results result NNS cord-005453-4057qib7 12606 2 : : : cord-005453-4057qib7 12607 1 According accord VBG cord-005453-4057qib7 12607 2 to to IN cord-005453-4057qib7 12607 3 the the DT cord-005453-4057qib7 12607 4 results result NNS cord-005453-4057qib7 12607 5 of of IN cord-005453-4057qib7 12607 6 the the DT cord-005453-4057qib7 12607 7 autologous autologous JJ cord-005453-4057qib7 12607 8 transplant transplant NN cord-005453-4057qib7 12607 9 harvesting harvesting NN cord-005453-4057qib7 12607 10 , , , cord-005453-4057qib7 12607 11 two two CD cord-005453-4057qib7 12607 12 groups group NNS cord-005453-4057qib7 12607 13 of of IN cord-005453-4057qib7 12607 14 patients patient NNS cord-005453-4057qib7 12607 15 were be VBD cord-005453-4057qib7 12607 16 identified identify VBN cord-005453-4057qib7 12607 17 . . . cord-005453-4057qib7 12608 1 First first RB cord-005453-4057qib7 12608 2 included include VBD cord-005453-4057qib7 12608 3 65 65 CD cord-005453-4057qib7 12608 4 patients patient NNS cord-005453-4057qib7 12608 5 with with IN cord-005453-4057qib7 12608 6 an an DT cord-005453-4057qib7 12608 7 autograft autograft NN cord-005453-4057qib7 12608 8 cellularity cellularity NN cord-005453-4057qib7 12608 9 of of IN cord-005453-4057qib7 12608 10 more more JJR cord-005453-4057qib7 12608 11 than than IN cord-005453-4057qib7 12608 12 2×10 2×10 CD cord-005453-4057qib7 12608 13 6 6 CD cord-005453-4057qib7 12608 14 /kg /kg CD cord-005453-4057qib7 12608 15 body body NN cord-005453-4057qib7 12608 16 weight weight NN cord-005453-4057qib7 12608 17 . . . cord-005453-4057qib7 12609 1 The the DT cord-005453-4057qib7 12609 2 second second JJ cord-005453-4057qib7 12609 3 group group NN cord-005453-4057qib7 12609 4 consisted consist VBD cord-005453-4057qib7 12609 5 of of IN cord-005453-4057qib7 12609 6 13 13 CD cord-005453-4057qib7 12609 7 patients patient NNS cord-005453-4057qib7 12609 8 examined examine VBN cord-005453-4057qib7 12609 9 with with IN cord-005453-4057qib7 12609 10 the the DT cord-005453-4057qib7 12609 11 number number NN cord-005453-4057qib7 12609 12 of of IN cord-005453-4057qib7 12609 13 CD34 CD34 NNP cord-005453-4057qib7 12609 14 + + CC cord-005453-4057qib7 12609 15 cells cell NNS cord-005453-4057qib7 12609 16 in in IN cord-005453-4057qib7 12609 17 the the DT cord-005453-4057qib7 12609 18 autograft autograft NN cord-005453-4057qib7 12609 19 ≤2×10 ≤2×10 NNP cord-005453-4057qib7 12609 20 6 6 CD cord-005453-4057qib7 12609 21 /kg /kg NFP cord-005453-4057qib7 12609 22 of of IN cord-005453-4057qib7 12609 23 the the DT cord-005453-4057qib7 12609 24 patient patient NN cord-005453-4057qib7 12609 25 's 's POS cord-005453-4057qib7 12609 26 body body NN cord-005453-4057qib7 12609 27 weight weight NN cord-005453-4057qib7 12609 28 . . . cord-005453-4057qib7 12610 1 Comparing compare VBG cord-005453-4057qib7 12610 2 the the DT cord-005453-4057qib7 12610 3 identified identify VBN cord-005453-4057qib7 12610 4 haplotypes haplotype NNS cord-005453-4057qib7 12610 5 of of IN cord-005453-4057qib7 12610 6 the the DT cord-005453-4057qib7 12610 7 immune immune JJ cord-005453-4057qib7 12610 8 response response NN cord-005453-4057qib7 12610 9 genes gene NNS cord-005453-4057qib7 12610 10 with with IN cord-005453-4057qib7 12610 11 the the DT cord-005453-4057qib7 12610 12 cellularity cellularity NN cord-005453-4057qib7 12610 13 of of IN cord-005453-4057qib7 12610 14 the the DT cord-005453-4057qib7 12610 15 transplantation transplantation NN cord-005453-4057qib7 12610 16 material material NN cord-005453-4057qib7 12610 17 , , , cord-005453-4057qib7 12610 18 it -PRON- PRP cord-005453-4057qib7 12610 19 was be VBD cord-005453-4057qib7 12610 20 found find VBN cord-005453-4057qib7 12610 21 that that IN cord-005453-4057qib7 12610 22 the the DT cord-005453-4057qib7 12610 23 presence presence NN cord-005453-4057qib7 12610 24 of of IN cord-005453-4057qib7 12610 25 the the DT cord-005453-4057qib7 12610 26 mutant mutant JJ cord-005453-4057qib7 12610 27 allele allele NN cord-005453-4057qib7 12610 28 in in IN cord-005453-4057qib7 12610 29 the the DT cord-005453-4057qib7 12610 30 homo homo NN cord-005453-4057qib7 12610 31 - - HYPH cord-005453-4057qib7 12610 32 and and CC cord-005453-4057qib7 12610 33 heterozygous heterozygous JJ cord-005453-4057qib7 12610 34 haplotypes haplotype NNS cord-005453-4057qib7 12610 35 of of IN cord-005453-4057qib7 12610 36 the the DT cord-005453-4057qib7 12610 37 IL1β IL1β NNP cord-005453-4057qib7 12610 38 gene gene NN cord-005453-4057qib7 12610 39 ( ( -LRB- cord-005453-4057qib7 12610 40 T-511C T-511C NNP cord-005453-4057qib7 12610 41 ) ) -RRB- cord-005453-4057qib7 12610 42 increased increase VBD cord-005453-4057qib7 12610 43 the the DT cord-005453-4057qib7 12610 44 chances chance NNS cord-005453-4057qib7 12610 45 of of IN cord-005453-4057qib7 12610 46 harvesting harvest VBG cord-005453-4057qib7 12610 47 cellular cellular JJ cord-005453-4057qib7 12610 48 material material NN cord-005453-4057qib7 12610 49 with with IN cord-005453-4057qib7 12610 50 a a DT cord-005453-4057qib7 12610 51 higher high JJR cord-005453-4057qib7 12610 52 content content NN cord-005453-4057qib7 12610 53 of of IN cord-005453-4057qib7 12610 54 CD34 CD34 NNP cord-005453-4057qib7 12610 55 + + CC cord-005453-4057qib7 12610 56 cells cell NNS cord-005453-4057qib7 12610 57 in in IN cord-005453-4057qib7 12610 58 4 4 CD cord-005453-4057qib7 12610 59 times time NNS cord-005453-4057qib7 12610 60 ( ( -LRB- cord-005453-4057qib7 12610 61 χ2=5.04 χ2=5.04 NFP cord-005453-4057qib7 12610 62 , , , cord-005453-4057qib7 12610 63 p=0.02 p=0.02 NNP cord-005453-4057qib7 12610 64 ) ) -RRB- cord-005453-4057qib7 12610 65 , , , cord-005453-4057qib7 12610 66 and and CC cord-005453-4057qib7 12610 67 the the DT cord-005453-4057qib7 12610 68 carriage carriage NN cord-005453-4057qib7 12610 69 of of IN cord-005453-4057qib7 12610 70 the the DT cord-005453-4057qib7 12610 71 wild wild JJ cord-005453-4057qib7 12610 72 type type NN cord-005453-4057qib7 12610 73 allele allele NN cord-005453-4057qib7 12610 74 in in IN cord-005453-4057qib7 12610 75 the the DT cord-005453-4057qib7 12610 76 homo homo NN cord-005453-4057qib7 12610 77 - - HYPH cord-005453-4057qib7 12610 78 and and CC cord-005453-4057qib7 12610 79 heterozygous heterozygous JJ cord-005453-4057qib7 12610 80 state state NN cord-005453-4057qib7 12610 81 of of IN cord-005453-4057qib7 12610 82 the the DT cord-005453-4057qib7 12610 83 TLR2 TLR2 NNP cord-005453-4057qib7 12610 84 ( ( -LRB- cord-005453-4057qib7 12610 85 Arg753Gln arg753gln NN cord-005453-4057qib7 12610 86 ) ) -RRB- cord-005453-4057qib7 12610 87 gene gene NN cord-005453-4057qib7 12610 88 is be VBZ cord-005453-4057qib7 12610 89 more more JJR cord-005453-4057qib7 12610 90 than than IN cord-005453-4057qib7 12610 91 in in IN cord-005453-4057qib7 12610 92 15 15 CD cord-005453-4057qib7 12610 93 times time NNS cord-005453-4057qib7 12610 94 ( ( -LRB- cord-005453-4057qib7 12610 95 χ2=5.06 χ2=5.06 NNP cord-005453-4057qib7 12610 96 , , , cord-005453-4057qib7 12610 97 p=0.02 p=0.02 NNP cord-005453-4057qib7 12610 98 ) ) -RRB- cord-005453-4057qib7 12610 99 . . . cord-005453-4057qib7 12611 1 Currently currently RB cord-005453-4057qib7 12611 2 , , , cord-005453-4057qib7 12611 3 it -PRON- PRP cord-005453-4057qib7 12611 4 has have VBZ cord-005453-4057qib7 12611 5 been be VBN cord-005453-4057qib7 12611 6 shown show VBN cord-005453-4057qib7 12611 7 that that IN cord-005453-4057qib7 12611 8 single single JJ cord-005453-4057qib7 12611 9 nucleotide nucleotide NN cord-005453-4057qib7 12611 10 or or CC cord-005453-4057qib7 12611 11 amino amino NN cord-005453-4057qib7 12611 12 acid acid NN cord-005453-4057qib7 12611 13 substitutions substitution NNS cord-005453-4057qib7 12611 14 in in IN cord-005453-4057qib7 12611 15 genes gene NNS cord-005453-4057qib7 12611 16 can can MD cord-005453-4057qib7 12611 17 lead lead VB cord-005453-4057qib7 12611 18 to to IN cord-005453-4057qib7 12611 19 changes change NNS cord-005453-4057qib7 12611 20 in in IN cord-005453-4057qib7 12611 21 the the DT cord-005453-4057qib7 12611 22 expression expression NN cord-005453-4057qib7 12611 23 pattern pattern NN cord-005453-4057qib7 12611 24 of of IN cord-005453-4057qib7 12611 25 their -PRON- PRP$ cord-005453-4057qib7 12611 26 final final JJ cord-005453-4057qib7 12611 27 products product NNS cord-005453-4057qib7 12611 28 : : : cord-005453-4057qib7 12611 29 increased increase VBN cord-005453-4057qib7 12611 30 secretion secretion NN cord-005453-4057qib7 12611 31 of of IN cord-005453-4057qib7 12611 32 interleukin interleukin NN cord-005453-4057qib7 12611 33 1β 1β CD cord-005453-4057qib7 12611 34 ( ( -LRB- cord-005453-4057qib7 12611 35 IL-1β il-1β NN cord-005453-4057qib7 12611 36 ) ) -RRB- cord-005453-4057qib7 12611 37 or or CC cord-005453-4057qib7 12611 38 changes change NNS cord-005453-4057qib7 12611 39 in in IN cord-005453-4057qib7 12611 40 the the DT cord-005453-4057qib7 12611 41 spatial spatial JJ cord-005453-4057qib7 12611 42 configuration configuration NN cord-005453-4057qib7 12611 43 and and CC cord-005453-4057qib7 12611 44 functionality functionality NN cord-005453-4057qib7 12611 45 of of IN cord-005453-4057qib7 12611 46 the the DT cord-005453-4057qib7 12611 47 receptors receptor NNS cord-005453-4057qib7 12611 48 ( ( -LRB- cord-005453-4057qib7 12611 49 TLR2 TLR2 NNP cord-005453-4057qib7 12611 50 ) ) -RRB- cord-005453-4057qib7 12611 51 . . . cord-005453-4057qib7 12612 1 Thus thus RB cord-005453-4057qib7 12612 2 , , , cord-005453-4057qib7 12612 3 in in IN cord-005453-4057qib7 12612 4 the the DT cord-005453-4057qib7 12612 5 presence presence NN cord-005453-4057qib7 12612 6 of of IN cord-005453-4057qib7 12612 7 mutations mutation NNS cord-005453-4057qib7 12612 8 in in IN cord-005453-4057qib7 12612 9 the the DT cord-005453-4057qib7 12612 10 IL1β IL1β NNP cord-005453-4057qib7 12612 11 gene gene NN cord-005453-4057qib7 12612 12 , , , cord-005453-4057qib7 12612 13 the the DT cord-005453-4057qib7 12612 14 enhanced enhanced JJ cord-005453-4057qib7 12612 15 synthesis synthesis NN cord-005453-4057qib7 12612 16 of of IN cord-005453-4057qib7 12612 17 IL-1β il-1β JJ cord-005453-4057qib7 12612 18 influences influence NNS cord-005453-4057qib7 12612 19 on on IN cord-005453-4057qib7 12612 20 fibroblasts fibroblast NNS cord-005453-4057qib7 12612 21 , , , cord-005453-4057qib7 12612 22 immunocompetent immunocompetent JJ cord-005453-4057qib7 12612 23 , , , cord-005453-4057qib7 12612 24 endothelial endothelial JJ cord-005453-4057qib7 12612 25 , , , cord-005453-4057qib7 12612 26 epithelial epithelial JJ cord-005453-4057qib7 12612 27 and and CC cord-005453-4057qib7 12612 28 other other JJ cord-005453-4057qib7 12612 29 cells cell NNS cord-005453-4057qib7 12612 30 , , , cord-005453-4057qib7 12612 31 by by IN cord-005453-4057qib7 12612 32 activating activate VBG cord-005453-4057qib7 12612 33 hemopoiesis hemopoiesis NNP cord-005453-4057qib7 12612 34 . . . cord-005453-4057qib7 12613 1 In in IN cord-005453-4057qib7 12613 2 turn turn NN cord-005453-4057qib7 12613 3 , , , cord-005453-4057qib7 12613 4 the the DT cord-005453-4057qib7 12613 5 mutational mutational JJ cord-005453-4057qib7 12613 6 status status NN cord-005453-4057qib7 12613 7 of of IN cord-005453-4057qib7 12613 8 the the DT cord-005453-4057qib7 12613 9 Arg753Gln arg753gln CD cord-005453-4057qib7 12613 10 locus locus NN cord-005453-4057qib7 12613 11 located locate VBN cord-005453-4057qib7 12613 12 within within IN cord-005453-4057qib7 12613 13 the the DT cord-005453-4057qib7 12613 14 TIR TIR NNP cord-005453-4057qib7 12613 15 domain domain NN cord-005453-4057qib7 12613 16 of of IN cord-005453-4057qib7 12613 17 the the DT cord-005453-4057qib7 12613 18 TLR2 TLR2 NNP cord-005453-4057qib7 12613 19 receptor receptor NN cord-005453-4057qib7 12613 20 in in IN cord-005453-4057qib7 12613 21 the the DT cord-005453-4057qib7 12613 22 cytosol cytosol NN cord-005453-4057qib7 12613 23 , , , cord-005453-4057qib7 12613 24 determines determine VBZ cord-005453-4057qib7 12613 25 the the DT cord-005453-4057qib7 12613 26 spatial spatial JJ cord-005453-4057qib7 12613 27 configuration configuration NN cord-005453-4057qib7 12613 28 of of IN cord-005453-4057qib7 12613 29 the the DT cord-005453-4057qib7 12613 30 TLR2 TLR2 NNP cord-005453-4057qib7 12613 31 acting acting NN cord-005453-4057qib7 12613 32 as as IN cord-005453-4057qib7 12613 33 a a DT cord-005453-4057qib7 12613 34 co co JJ cord-005453-4057qib7 12613 35 - - JJ cord-005453-4057qib7 12613 36 stimulatory stimulatory JJ cord-005453-4057qib7 12613 37 receptor receptor NN cord-005453-4057qib7 12613 38 of of IN cord-005453-4057qib7 12613 39 CD4 CD4 NNP cord-005453-4057qib7 12613 40 + + CC cord-005453-4057qib7 12613 41 cells cell NNS cord-005453-4057qib7 12613 42 , , , cord-005453-4057qib7 12613 43 which which WDT cord-005453-4057qib7 12613 44 ensure ensure VBP cord-005453-4057qib7 12613 45 the the DT cord-005453-4057qib7 12613 46 engraftment engraftment NN cord-005453-4057qib7 12613 47 of of IN cord-005453-4057qib7 12613 48 the the DT cord-005453-4057qib7 12613 49 graft graft NN cord-005453-4057qib7 12613 50 . . . cord-005453-4057qib7 12614 1 Conclusions conclusion NNS cord-005453-4057qib7 12614 2 : : : cord-005453-4057qib7 12615 1 Identified identify VBN cord-005453-4057qib7 12615 2 haplotypical haplotypical NN cord-005453-4057qib7 12615 3 features feature NNS cord-005453-4057qib7 12615 4 of of IN cord-005453-4057qib7 12615 5 the the DT cord-005453-4057qib7 12615 6 IL1β IL1β NNP cord-005453-4057qib7 12615 7 and and CC cord-005453-4057qib7 12615 8 TLR2 TLR2 NNP cord-005453-4057qib7 12615 9 genes gene NNS cord-005453-4057qib7 12615 10 in in IN cord-005453-4057qib7 12615 11 patients patient NNS cord-005453-4057qib7 12615 12 with with IN cord-005453-4057qib7 12615 13 MM MM NNP cord-005453-4057qib7 12615 14 may may MD cord-005453-4057qib7 12615 15 act act VB cord-005453-4057qib7 12615 16 as as IN cord-005453-4057qib7 12615 17 predictors predictor NNS cord-005453-4057qib7 12615 18 of of IN cord-005453-4057qib7 12615 19 the the DT cord-005453-4057qib7 12615 20 response response NN cord-005453-4057qib7 12615 21 effectiveness effectiveness NN cord-005453-4057qib7 12615 22 to to IN cord-005453-4057qib7 12615 23 mobilization mobilization NN cord-005453-4057qib7 12615 24 of of IN cord-005453-4057qib7 12615 25 HSCs hscs NN cord-005453-4057qib7 12615 26 in in IN cord-005453-4057qib7 12615 27 their -PRON- PRP$ cord-005453-4057qib7 12615 28 carriers carrier NNS cord-005453-4057qib7 12615 29 , , , cord-005453-4057qib7 12615 30 which which WDT cord-005453-4057qib7 12615 31 may may MD cord-005453-4057qib7 12615 32 contribute contribute VB cord-005453-4057qib7 12615 33 to to IN cord-005453-4057qib7 12615 34 the the DT cord-005453-4057qib7 12615 35 mobilization mobilization NN cord-005453-4057qib7 12615 36 regimen regimen NN cord-005453-4057qib7 12615 37 optimization optimization NN cord-005453-4057qib7 12615 38 and and CC cord-005453-4057qib7 12615 39 will will MD cord-005453-4057qib7 12615 40 contribute contribute VB cord-005453-4057qib7 12615 41 to to IN cord-005453-4057qib7 12615 42 harvesting harvest VBG cord-005453-4057qib7 12615 43 the the DT cord-005453-4057qib7 12615 44 optimal optimal JJ cord-005453-4057qib7 12615 45 cellularity cellularity NN cord-005453-4057qib7 12615 46 of of IN cord-005453-4057qib7 12615 47 an an DT cord-005453-4057qib7 12615 48 autologous autologous JJ cord-005453-4057qib7 12615 49 graft graft NN cord-005453-4057qib7 12615 50 . . . cord-005453-4057qib7 12616 1 Clinical clinical JJ cord-005453-4057qib7 12616 2 Trial Trial NNP cord-005453-4057qib7 12616 3 Registry Registry NNP cord-005453-4057qib7 12616 4 : : : cord-005453-4057qib7 12616 5 None none NN cord-005453-4057qib7 12616 6 . . . cord-005453-4057qib7 12617 1 Disclosure disclosure NN cord-005453-4057qib7 12617 2 : : : cord-005453-4057qib7 12618 1 Authors author NNS cord-005453-4057qib7 12618 2 declare declare VBP cord-005453-4057qib7 12618 3 no no DT cord-005453-4057qib7 12618 4 conflict conflict NN cord-005453-4057qib7 12618 5 of of IN cord-005453-4057qib7 12618 6 interest interest NN cord-005453-4057qib7 12618 7 . . . cord-005453-4057qib7 12619 1 Differentiating differentiate VBG cord-005453-4057qib7 12619 2 diffuse diffuse NN cord-005453-4057qib7 12619 3 from from IN cord-005453-4057qib7 12619 4 focal focal JJ cord-005453-4057qib7 12619 5 pattern pattern NN cord-005453-4057qib7 12619 6 on on IN cord-005453-4057qib7 12619 7 computed compute VBN cord-005453-4057qib7 12619 8 tomography tomography NN cord-005453-4057qib7 12619 9 : : : cord-005453-4057qib7 12619 10 Added add VBN cord-005453-4057qib7 12619 11 values value NNS cord-005453-4057qib7 12619 12 of of IN cord-005453-4057qib7 12619 13 a a DT cord-005453-4057qib7 12619 14 radiomics radiomic NNS cord-005453-4057qib7 12619 15 approach approach NN cord-005453-4057qib7 12619 16 Background background NN cord-005453-4057qib7 12619 17 : : : cord-005453-4057qib7 12620 1 Focal focal JJ cord-005453-4057qib7 12620 2 pattern pattern NN cord-005453-4057qib7 12620 3 in in IN cord-005453-4057qib7 12620 4 multiple multiple JJ cord-005453-4057qib7 12620 5 myeloma myeloma NN cord-005453-4057qib7 12620 6 ( ( -LRB- cord-005453-4057qib7 12620 7 MM MM NNP cord-005453-4057qib7 12620 8 ) ) -RRB- cord-005453-4057qib7 12620 9 seems seem VBZ cord-005453-4057qib7 12620 10 to to TO cord-005453-4057qib7 12620 11 be be VB cord-005453-4057qib7 12620 12 related relate VBN cord-005453-4057qib7 12620 13 to to IN cord-005453-4057qib7 12620 14 poorer poor JJR cord-005453-4057qib7 12620 15 survival survival NN cord-005453-4057qib7 12620 16 and and CC cord-005453-4057qib7 12620 17 differentiation differentiation NN cord-005453-4057qib7 12620 18 from from IN cord-005453-4057qib7 12620 19 diffuse diffuse JJ cord-005453-4057qib7 12620 20 to to IN cord-005453-4057qib7 12620 21 focal focal JJ cord-005453-4057qib7 12620 22 pattern pattern NN cord-005453-4057qib7 12620 23 on on IN cord-005453-4057qib7 12620 24 computed compute VBN cord-005453-4057qib7 12620 25 tomography tomography NN cord-005453-4057qib7 12620 26 ( ( -LRB- cord-005453-4057qib7 12620 27 CT CT NNP cord-005453-4057qib7 12620 28 ) ) -RRB- cord-005453-4057qib7 12620 29 has have VBZ cord-005453-4057qib7 12620 30 inter inter JJ cord-005453-4057qib7 12620 31 - - JJ cord-005453-4057qib7 12620 32 reader reader JJ cord-005453-4057qib7 12620 33 variability variability NN cord-005453-4057qib7 12620 34 . . . cord-005453-4057qib7 12621 1 Therefore therefore RB cord-005453-4057qib7 12621 2 the the DT cord-005453-4057qib7 12621 3 purpose purpose NN cord-005453-4057qib7 12621 4 of of IN cord-005453-4057qib7 12621 5 this this DT cord-005453-4057qib7 12621 6 study study NN cord-005453-4057qib7 12621 7 is be VBZ cord-005453-4057qib7 12621 8 to to TO cord-005453-4057qib7 12621 9 assess assess VB cord-005453-4057qib7 12621 10 if if IN cord-005453-4057qib7 12621 11 a a DT cord-005453-4057qib7 12621 12 Radiomic Radiomic NNP cord-005453-4057qib7 12621 13 approach approach NN cord-005453-4057qib7 12621 14 could could MD cord-005453-4057qib7 12621 15 help help VB cord-005453-4057qib7 12621 16 radiologists radiologist NNS cord-005453-4057qib7 12621 17 in in IN cord-005453-4057qib7 12621 18 differentiating differentiate VBG cord-005453-4057qib7 12621 19 diffuse diffuse NN cord-005453-4057qib7 12621 20 from from IN cord-005453-4057qib7 12621 21 focal focal JJ cord-005453-4057qib7 12621 22 patterns pattern NNS cord-005453-4057qib7 12621 23 . . . cord-005453-4057qib7 12622 1 Methods method NNS cord-005453-4057qib7 12622 2 : : : cord-005453-4057qib7 12622 3 We -PRON- PRP cord-005453-4057qib7 12622 4 retrospectively retrospectively RB cord-005453-4057qib7 12622 5 reviewed review VBD cord-005453-4057qib7 12622 6 imaging image VBG cord-005453-4057qib7 12622 7 data datum NNS cord-005453-4057qib7 12622 8 of of IN cord-005453-4057qib7 12622 9 70 70 CD cord-005453-4057qib7 12622 10 patients patient NNS cord-005453-4057qib7 12622 11 with with IN cord-005453-4057qib7 12622 12 MM MM NNP cord-005453-4057qib7 12622 13 between between IN cord-005453-4057qib7 12622 14 January January NNP cord-005453-4057qib7 12622 15 2013 2013 CD cord-005453-4057qib7 12622 16 and and CC cord-005453-4057qib7 12622 17 September September NNP cord-005453-4057qib7 12622 18 2018 2018 CD cord-005453-4057qib7 12622 19 of of IN cord-005453-4057qib7 12622 20 whom whom WP cord-005453-4057qib7 12622 21 61(27 61(27 CD cord-005453-4057qib7 12622 22 men man NNS cord-005453-4057qib7 12622 23 and and CC cord-005453-4057qib7 12622 24 34 34 CD cord-005453-4057qib7 12622 25 women woman NNS cord-005453-4057qib7 12622 26 ; ; : cord-005453-4057qib7 12622 27 mean mean VB cord-005453-4057qib7 12622 28 age age NN cord-005453-4057qib7 12622 29 54.2 54.2 CD cord-005453-4057qib7 12622 30 ±3.7 ±3.7 NNS cord-005453-4057qib7 12622 31 ) ) -RRB- cord-005453-4057qib7 12622 32 with with IN cord-005453-4057qib7 12622 33 CT CT NNP cord-005453-4057qib7 12622 34 , , , cord-005453-4057qib7 12622 35 PET PET NNP cord-005453-4057qib7 12622 36 - - HYPH cord-005453-4057qib7 12622 37 CT CT NNP cord-005453-4057qib7 12622 38 or or CC cord-005453-4057qib7 12622 39 MRI MRI NNP cord-005453-4057qib7 12622 40 available available JJ cord-005453-4057qib7 12622 41 before before IN cord-005453-4057qib7 12622 42 bone bone NN cord-005453-4057qib7 12622 43 marrow marrow NN cord-005453-4057qib7 12622 44 transplant transplant NN cord-005453-4057qib7 12622 45 . . . cord-005453-4057qib7 12623 1 Two two CD cord-005453-4057qib7 12623 2 general general JJ cord-005453-4057qib7 12623 3 radiologist radiologist NN cord-005453-4057qib7 12623 4 evaluated evaluate VBN cord-005453-4057qib7 12623 5 in in IN cord-005453-4057qib7 12623 6 consensus consensus NN cord-005453-4057qib7 12623 7 only only RB cord-005453-4057qib7 12623 8 CT CT NNP cord-005453-4057qib7 12623 9 images image NNS cord-005453-4057qib7 12623 10 to to TO cord-005453-4057qib7 12623 11 define define VB cord-005453-4057qib7 12623 12 a a DT cord-005453-4057qib7 12623 13 focal focal NN cord-005453-4057qib7 12623 14 ( ( -LRB- cord-005453-4057qib7 12623 15 at at RB cord-005453-4057qib7 12623 16 least least RBS cord-005453-4057qib7 12623 17 one one CD cord-005453-4057qib7 12623 18 lytic lytic JJ cord-005453-4057qib7 12623 19 lesion lesion NN cord-005453-4057qib7 12623 20 > > XX cord-005453-4057qib7 12623 21 5 5 CD cord-005453-4057qib7 12623 22 mm mm NN cord-005453-4057qib7 12623 23 in in IN cord-005453-4057qib7 12623 24 diameter diameter NN cord-005453-4057qib7 12623 25 ) ) -RRB- cord-005453-4057qib7 12623 26 or or CC cord-005453-4057qib7 12623 27 a a DT cord-005453-4057qib7 12623 28 diffuse diffuse NN cord-005453-4057qib7 12623 29 ( ( -LRB- cord-005453-4057qib7 12623 30 lesions lesion NNS cord-005453-4057qib7 12623 31 < < XX cord-005453-4057qib7 12623 32 5 5 CD cord-005453-4057qib7 12623 33 mm mm NNP cord-005453-4057qib7 12623 34 , , , cord-005453-4057qib7 12623 35 not not RB cord-005453-4057qib7 12623 36 osteoporosis osteoporosis NN cord-005453-4057qib7 12623 37 ) ) -RRB- cord-005453-4057qib7 12623 38 pattern pattern NN cord-005453-4057qib7 12623 39 . . . cord-005453-4057qib7 12624 1 Radiomic radiomic JJ cord-005453-4057qib7 12624 2 analysis analysis NN cord-005453-4057qib7 12624 3 on on IN cord-005453-4057qib7 12624 4 CT CT NNP cord-005453-4057qib7 12624 5 thinslice thinslice NN cord-005453-4057qib7 12624 6 images image NNS cord-005453-4057qib7 12624 7 was be VBD cord-005453-4057qib7 12624 8 then then RB cord-005453-4057qib7 12624 9 applied apply VBN cord-005453-4057qib7 12624 10 with with IN cord-005453-4057qib7 12624 11 regions region NNS cord-005453-4057qib7 12624 12 of of IN cord-005453-4057qib7 12624 13 interest interest NN cord-005453-4057qib7 12624 14 ( ( -LRB- cord-005453-4057qib7 12624 15 ROIs ROIs NNP cord-005453-4057qib7 12624 16 ) ) -RRB- cord-005453-4057qib7 12624 17 done do VBN cord-005453-4057qib7 12624 18 by by IN cord-005453-4057qib7 12624 19 one one CD cord-005453-4057qib7 12624 20 Researcher Researcher NNP cord-005453-4057qib7 12624 21 not not RB cord-005453-4057qib7 12624 22 expert expert VB cord-005453-4057qib7 12624 23 in in IN cord-005453-4057qib7 12624 24 Medical Medical NNP cord-005453-4057qib7 12624 25 Imaging Imaging NNP cord-005453-4057qib7 12624 26 or or CC cord-005453-4057qib7 12624 27 MM MM NNP cord-005453-4057qib7 12624 28 blindly blindly RB cord-005453-4057qib7 12624 29 to to IN cord-005453-4057qib7 12624 30 the the DT cord-005453-4057qib7 12624 31 condition condition NN cord-005453-4057qib7 12624 32 of of IN cord-005453-4057qib7 12624 33 the the DT cord-005453-4057qib7 12624 34 patients patient NNS cord-005453-4057qib7 12624 35 . . . cord-005453-4057qib7 12625 1 The the DT cord-005453-4057qib7 12625 2 reference reference NN cord-005453-4057qib7 12625 3 standard standard NN cord-005453-4057qib7 12625 4 to to TO cord-005453-4057qib7 12625 5 differentiate differentiate VB cord-005453-4057qib7 12625 6 diffuse diffuse NN cord-005453-4057qib7 12625 7 from from IN cord-005453-4057qib7 12625 8 focal focal JJ cord-005453-4057qib7 12625 9 pattern pattern NN cord-005453-4057qib7 12625 10 was be VBD cord-005453-4057qib7 12625 11 done do VBN cord-005453-4057qib7 12625 12 by by IN cord-005453-4057qib7 12625 13 radiological radiological JJ cord-005453-4057qib7 12625 14 evaluation evaluation NN cord-005453-4057qib7 12625 15 of of IN cord-005453-4057qib7 12625 16 two two CD cord-005453-4057qib7 12625 17 expert expert JJ cord-005453-4057qib7 12625 18 musculosketal musculosketal JJ cord-005453-4057qib7 12625 19 radiologists radiologist NNS cord-005453-4057qib7 12625 20 blinded blind VBD cord-005453-4057qib7 12625 21 to to IN cord-005453-4057qib7 12625 22 the the DT cord-005453-4057qib7 12625 23 clinical clinical JJ cord-005453-4057qib7 12625 24 data datum NNS cord-005453-4057qib7 12625 25 reviewing review VBG cord-005453-4057qib7 12625 26 CT CT NNP cord-005453-4057qib7 12625 27 , , , cord-005453-4057qib7 12625 28 MRI MRI NNP cord-005453-4057qib7 12625 29 and and CC cord-005453-4057qib7 12625 30 PET PET NNP cord-005453-4057qib7 12625 31 - - HYPH cord-005453-4057qib7 12625 32 CT CT NNP cord-005453-4057qib7 12625 33 images image NNS cord-005453-4057qib7 12625 34 . . . cord-005453-4057qib7 12626 1 N=104 N=104 NNP cord-005453-4057qib7 12626 2 Radiomics Radiomics NNP cord-005453-4057qib7 12626 3 features feature NNS cord-005453-4057qib7 12626 4 were be VBD cord-005453-4057qib7 12626 5 extracted extract VBN cord-005453-4057qib7 12626 6 and and CC cord-005453-4057qib7 12626 7 evaluated evaluate VBN cord-005453-4057qib7 12626 8 with with IN cord-005453-4057qib7 12626 9 an an DT cord-005453-4057qib7 12626 10 open open JJ cord-005453-4057qib7 12626 11 source source NN cord-005453-4057qib7 12626 12 software software NN cord-005453-4057qib7 12626 13 . . . cord-005453-4057qib7 12627 1 Mann Mann NNP cord-005453-4057qib7 12627 2 - - HYPH cord-005453-4057qib7 12627 3 Whitney Whitney NNP cord-005453-4057qib7 12627 4 U U NNP cord-005453-4057qib7 12627 5 test test VBP cord-005453-4057qib7 12627 6 for for IN cord-005453-4057qib7 12627 7 unpaired unpaired JJ cord-005453-4057qib7 12627 8 data datum NNS cord-005453-4057qib7 12627 9 with with IN cord-005453-4057qib7 12627 10 1000 1000 CD cord-005453-4057qib7 12627 11 bootstraps bootstraps NN cord-005453-4057qib7 12627 12 samples sample NNS cord-005453-4057qib7 12627 13 was be VBD cord-005453-4057qib7 12627 14 used use VBN cord-005453-4057qib7 12627 15 to to TO cord-005453-4057qib7 12627 16 compare compare VB cord-005453-4057qib7 12627 17 Radiomics Radiomics NNP cord-005453-4057qib7 12627 18 features feature NNS cord-005453-4057qib7 12627 19 of of IN cord-005453-4057qib7 12627 20 diffuse diffuse JJ cord-005453-4057qib7 12627 21 and and CC cord-005453-4057qib7 12627 22 focal focal JJ cord-005453-4057qib7 12627 23 patterns pattern NNS cord-005453-4057qib7 12627 24 and and CC cord-005453-4057qib7 12627 25 then then RB cord-005453-4057qib7 12627 26 feature feature VBP cord-005453-4057qib7 12627 27 reduction reduction NN cord-005453-4057qib7 12627 28 was be VBD cord-005453-4057qib7 12627 29 done do VBN cord-005453-4057qib7 12627 30 to to TO cord-005453-4057qib7 12627 31 avoid avoid VB cord-005453-4057qib7 12627 32 over over RB cord-005453-4057qib7 12627 33 - - HYPH cord-005453-4057qib7 12627 34 fitting fitting NN cord-005453-4057qib7 12627 35 . . . cord-005453-4057qib7 12628 1 Receiver Receiver NNP cord-005453-4057qib7 12628 2 Operator Operator NNP cord-005453-4057qib7 12628 3 Characteristic Characteristic NNP cord-005453-4057qib7 12628 4 ( ( -LRB- cord-005453-4057qib7 12628 5 ROC ROC NNP cord-005453-4057qib7 12628 6 ) ) -RRB- cord-005453-4057qib7 12628 7 analysis analysis NN cord-005453-4057qib7 12628 8 with with IN cord-005453-4057qib7 12628 9 area area NN cord-005453-4057qib7 12628 10 under under IN cord-005453-4057qib7 12628 11 the the DT cord-005453-4057qib7 12628 12 curve curve NN cord-005453-4057qib7 12628 13 was be VBD cord-005453-4057qib7 12628 14 done do VBN cord-005453-4057qib7 12628 15 to to TO cord-005453-4057qib7 12628 16 compare compare VB cord-005453-4057qib7 12628 17 Radiologists Radiologists NNPS cord-005453-4057qib7 12628 18 and and CC cord-005453-4057qib7 12628 19 Radiomics Radiomics NNP cord-005453-4057qib7 12628 20 evaluation evaluation NN cord-005453-4057qib7 12628 21 against against IN cord-005453-4057qib7 12628 22 reference reference NN cord-005453-4057qib7 12628 23 standard standard NN cord-005453-4057qib7 12628 24 . . . cord-005453-4057qib7 12629 1 Reading read VBG cord-005453-4057qib7 12629 2 time time NN cord-005453-4057qib7 12629 3 to to TO cord-005453-4057qib7 12629 4 perform perform VB cord-005453-4057qib7 12629 5 Radiomic Radiomic NNP cord-005453-4057qib7 12629 6 analysis analysis NN cord-005453-4057qib7 12629 7 was be VBD cord-005453-4057qib7 12629 8 also also RB cord-005453-4057qib7 12629 9 estimated estimate VBN cord-005453-4057qib7 12629 10 . . . cord-005453-4057qib7 12630 1 Results result NNS cord-005453-4057qib7 12630 2 : : : cord-005453-4057qib7 12631 1 The the DT cord-005453-4057qib7 12631 2 pathological pathological JJ cord-005453-4057qib7 12631 3 group group NN cord-005453-4057qib7 12631 4 included include VBD cord-005453-4057qib7 12631 5 : : : cord-005453-4057qib7 12631 6 22 22 CD cord-005453-4057qib7 12631 7 diffuse diffuse NN cord-005453-4057qib7 12631 8 and and CC cord-005453-4057qib7 12631 9 39 39 CD cord-005453-4057qib7 12631 10 focal focal JJ cord-005453-4057qib7 12631 11 patterns pattern NNS cord-005453-4057qib7 12631 12 . . . cord-005453-4057qib7 12632 1 After after IN cord-005453-4057qib7 12632 2 feature feature NN cord-005453-4057qib7 12632 3 reduction reduction NN cord-005453-4057qib7 12632 4 , , , cord-005453-4057qib7 12632 5 9 9 CD cord-005453-4057qib7 12632 6 features feature NNS cord-005453-4057qib7 12632 7 were be VBD cord-005453-4057qib7 12632 8 different different JJ cord-005453-4057qib7 12632 9 ( ( -LRB- cord-005453-4057qib7 12632 10 p p NN cord-005453-4057qib7 12632 11 < < XX cord-005453-4057qib7 12632 12 0.05 0.05 CD cord-005453-4057qib7 12632 13 ) ) -RRB- cord-005453-4057qib7 12632 14 in in IN cord-005453-4057qib7 12632 15 the the DT cord-005453-4057qib7 12632 16 diffuse diffuse JJ cord-005453-4057qib7 12632 17 and and CC cord-005453-4057qib7 12632 18 focal focal JJ cord-005453-4057qib7 12632 19 patterns pattern NNS cord-005453-4057qib7 12632 20 ( ( -LRB- cord-005453-4057qib7 12632 21 n=2/9 n=2/9 VBP cord-005453-4057qib7 12632 22 features feature NNS cord-005453-4057qib7 12632 23 were be VBD cord-005453-4057qib7 12632 24 Shape shape NN cord-005453-4057qib7 12632 25 - - HYPH cord-005453-4057qib7 12632 26 based base VBN cord-005453-4057qib7 12632 27 : : : cord-005453-4057qib7 12632 28 MajorAxisLength majoraxislength NN cord-005453-4057qib7 12632 29 and and CC cord-005453-4057qib7 12632 30 Sphericity sphericity NN cord-005453-4057qib7 12632 31 ; ; : cord-005453-4057qib7 12632 32 n=7/9 n=7/9 ADD cord-005453-4057qib7 12632 33 were be VBD cord-005453-4057qib7 12632 34 Gray Gray NNP cord-005453-4057qib7 12632 35 Level Level NNP cord-005453-4057qib7 12632 36 Run Run NNP cord-005453-4057qib7 12632 37 Length length NN cord-005453-4057qib7 12632 38 Matrix Matrix NNP cord-005453-4057qib7 12632 39 ( ( -LRB- cord-005453-4057qib7 12632 40 Glrlm Glrlm NNP cord-005453-4057qib7 12632 41 ) ) -RRB- cord-005453-4057qib7 12632 42 ) ) -RRB- cord-005453-4057qib7 12632 43 . . . cord-005453-4057qib7 12633 1 150mg 150mg NNP cord-005453-4057qib7 12633 2 / / SYM cord-005453-4057qib7 12633 3 kg kg NNP cord-005453-4057qib7 12633 4 ) ) -RRB- cord-005453-4057qib7 12633 5 . . . cord-005453-4057qib7 12634 1 A a DT cord-005453-4057qib7 12634 2 number number NN cord-005453-4057qib7 12634 3 of of IN cord-005453-4057qib7 12634 4 eleven eleven CD cord-005453-4057qib7 12634 5 patients patient NNS cord-005453-4057qib7 12634 6 did do VBD cord-005453-4057qib7 12634 7 not not RB cord-005453-4057qib7 12634 8 receive receive VB cord-005453-4057qib7 12634 9 any any DT cord-005453-4057qib7 12634 10 additional additional JJ cord-005453-4057qib7 12634 11 immunosuppression immunosuppression NN cord-005453-4057qib7 12634 12 except except IN cord-005453-4057qib7 12634 13 of of IN cord-005453-4057qib7 12634 14 post post JJ cord-005453-4057qib7 12634 15 - - JJ cord-005453-4057qib7 12634 16 Cy Cy NNP cord-005453-4057qib7 12634 17 . . . cord-005453-4057qib7 12635 1 Results result NNS cord-005453-4057qib7 12635 2 : : : cord-005453-4057qib7 12636 1 After after IN cord-005453-4057qib7 12636 2 a a DT cord-005453-4057qib7 12636 3 median median NN cord-005453-4057qib7 12636 4 follow follow NN cord-005453-4057qib7 12636 5 up up IN cord-005453-4057qib7 12636 6 of of IN cord-005453-4057qib7 12636 7 11.4 11.4 CD cord-005453-4057qib7 12636 8 months month NNS cord-005453-4057qib7 12636 9 ( ( -LRB- cord-005453-4057qib7 12636 10 range range VBP cord-005453-4057qib7 12636 11 3.3 3.3 CD cord-005453-4057qib7 12636 12 -34.5 -34.5 NFP cord-005453-4057qib7 12636 13 ) ) -RRB- cord-005453-4057qib7 12637 1 28 28 CD cord-005453-4057qib7 12637 2 patients patient NNS cord-005453-4057qib7 12637 3 were be VBD cord-005453-4057qib7 12637 4 alive alive JJ cord-005453-4057qib7 12637 5 . . . cord-005453-4057qib7 12638 1 The the DT cord-005453-4057qib7 12638 2 2-year 2-year CD cord-005453-4057qib7 12638 3 probabilities probability NNS cord-005453-4057qib7 12638 4 of of IN cord-005453-4057qib7 12638 5 PFS PFS NNP cord-005453-4057qib7 12638 6 and and CC cord-005453-4057qib7 12638 7 OS OS NNP cord-005453-4057qib7 12638 8 were be VBD cord-005453-4057qib7 12638 9 42 42 CD cord-005453-4057qib7 12638 10 % % NN cord-005453-4057qib7 12638 11 ( ( -LRB- cord-005453-4057qib7 12638 12 21 21 CD cord-005453-4057qib7 12638 13 - - SYM cord-005453-4057qib7 12638 14 63 63 CD cord-005453-4057qib7 12638 15 % % NN cord-005453-4057qib7 12638 16 ) ) -RRB- cord-005453-4057qib7 12638 17 and and CC cord-005453-4057qib7 12638 18 65 65 CD cord-005453-4057qib7 12638 19 % % NN cord-005453-4057qib7 12638 20 ( ( -LRB- cord-005453-4057qib7 12638 21 47 47 CD cord-005453-4057qib7 12638 22 - - SYM cord-005453-4057qib7 12638 23 83%).The 83%).the CD cord-005453-4057qib7 12638 24 cumulative cumulative JJ cord-005453-4057qib7 12638 25 incidences incidence NNS cord-005453-4057qib7 12638 26 ( ( -LRB- cord-005453-4057qib7 12638 27 CIs CIs NNP cord-005453-4057qib7 12638 28 ) ) -RRB- cord-005453-4057qib7 12638 29 of of IN cord-005453-4057qib7 12638 30 relapse relapse NN cord-005453-4057qib7 12638 31 and and CC cord-005453-4057qib7 12639 1 NRM NRM NNP cord-005453-4057qib7 12639 2 at at IN cord-005453-4057qib7 12639 3 2 2 CD cord-005453-4057qib7 12639 4 years year NNS cord-005453-4057qib7 12639 5 were be VBD cord-005453-4057qib7 12639 6 28 28 CD cord-005453-4057qib7 12639 7 % % NN cord-005453-4057qib7 12639 8 ( ( -LRB- cord-005453-4057qib7 12639 9 11 11 CD cord-005453-4057qib7 12639 10 - - SYM cord-005453-4057qib7 12639 11 45 45 CD cord-005453-4057qib7 12639 12 % % NN cord-005453-4057qib7 12639 13 ) ) -RRB- cord-005453-4057qib7 12639 14 and and CC cord-005453-4057qib7 12639 15 22 22 CD cord-005453-4057qib7 12639 16 % % NN cord-005453-4057qib7 12639 17 ( ( -LRB- cord-005453-4057qib7 12639 18 8 8 CD cord-005453-4057qib7 12639 19 - - SYM cord-005453-4057qib7 12639 20 36 36 CD cord-005453-4057qib7 12639 21 % % NN cord-005453-4057qib7 12639 22 ) ) -RRB- cord-005453-4057qib7 12639 23 , , , cord-005453-4057qib7 12639 24 respectively respectively RB cord-005453-4057qib7 12639 25 . . . cord-005453-4057qib7 12640 1 Lower low JJR cord-005453-4057qib7 12640 2 serum serum NN cord-005453-4057qib7 12640 3 albumin albumin NN cord-005453-4057qib7 12640 4 level level NN cord-005453-4057qib7 12640 5 at at IN cord-005453-4057qib7 12640 6 transplantation transplantation NN cord-005453-4057qib7 12640 7 ( ( -LRB- cord-005453-4057qib7 12640 8 ≤36 ≤36 NNP cord-005453-4057qib7 12640 9 g g NN cord-005453-4057qib7 12640 10 / / SYM cord-005453-4057qib7 12640 11 dL dl NN cord-005453-4057qib7 12640 12 ) ) -RRB- cord-005453-4057qib7 12640 13 was be VBD cord-005453-4057qib7 12640 14 associated associate VBN cord-005453-4057qib7 12640 15 with with IN cord-005453-4057qib7 12640 16 increased increase VBN cord-005453-4057qib7 12640 17 relapses relapse NNS cord-005453-4057qib7 12640 18 ( ( -LRB- cord-005453-4057qib7 12640 19 HR HR NNP cord-005453-4057qib7 12640 20 3.8 3.8 CD cord-005453-4057qib7 12640 21 ( ( -LRB- cord-005453-4057qib7 12640 22 1.2 1.2 CD cord-005453-4057qib7 12640 23 - - SYM cord-005453-4057qib7 12640 24 12.7 12.7 CD cord-005453-4057qib7 12640 25 ) ) -RRB- cord-005453-4057qib7 12640 26 , , , cord-005453-4057qib7 12640 27 p=0.028 p=0.028 NN cord-005453-4057qib7 12640 28 ) ) -RRB- cord-005453-4057qib7 12640 29 and and CC cord-005453-4057qib7 12640 30 NRM NRM NNP cord-005453-4057qib7 12640 31 ( ( -LRB- cord-005453-4057qib7 12640 32 HR HR NNP cord-005453-4057qib7 12640 33 7.9 7.9 CD cord-005453-4057qib7 12640 34 ( ( -LRB- cord-005453-4057qib7 12640 35 2 2 CD cord-005453-4057qib7 12640 36 - - SYM cord-005453-4057qib7 12640 37 30 30 CD cord-005453-4057qib7 12640 38 ) ) -RRB- cord-005453-4057qib7 12640 39 , , , cord-005453-4057qib7 12640 40 p=0.0026 p=0.0026 NNP cord-005453-4057qib7 12640 41 ) ) -RRB- cord-005453-4057qib7 12640 42 and and CC cord-005453-4057qib7 12640 43 resulted result VBD cord-005453-4057qib7 12640 44 in in IN cord-005453-4057qib7 12640 45 poorer poor JJR cord-005453-4057qib7 12640 46 PFS PFS NNP cord-005453-4057qib7 12640 47 ) ) -RRB- cord-005453-4057qib7 12640 48 , , , cord-005453-4057qib7 12640 49 p=0.001 p=0.001 NNP cord-005453-4057qib7 12640 50 ) ) -RRB- cord-005453-4057qib7 12640 51 and and CC cord-005453-4057qib7 12640 52 OS OS NNP cord-005453-4057qib7 12640 53 ) ) -RRB- cord-005453-4057qib7 12640 54 , , , cord-005453-4057qib7 12640 55 p=0.048 p=0.048 NNP cord-005453-4057qib7 12640 56 ) ) -RRB- cord-005453-4057qib7 12640 57 . . . cord-005453-4057qib7 12641 1 MMUD MMUD NNP cord-005453-4057qib7 12641 2 and and CC cord-005453-4057qib7 12641 3 haploidentical haploidentical JJ cord-005453-4057qib7 12641 4 donors donor NNS cord-005453-4057qib7 12641 5 were be VBD cord-005453-4057qib7 12641 6 associated associate VBN cord-005453-4057qib7 12641 7 with with IN cord-005453-4057qib7 12641 8 poorer poor JJR cord-005453-4057qib7 12641 9 NRM NRM NNP cord-005453-4057qib7 12641 10 ( ( -LRB- cord-005453-4057qib7 12641 11 HR HR NNP cord-005453-4057qib7 12641 12 6.2 6.2 CD cord-005453-4057qib7 12641 13 ( ( -LRB- cord-005453-4057qib7 12641 14 1.9 1.9 CD cord-005453-4057qib7 12641 15 - - SYM cord-005453-4057qib7 12641 16 20.3 20.3 CD cord-005453-4057qib7 12641 17 ) ) -RRB- cord-005453-4057qib7 12641 18 , , , cord-005453-4057qib7 12641 19 p=0.0027 p=0.0027 NNP cord-005453-4057qib7 12641 20 ) ) -RRB- cord-005453-4057qib7 12641 21 , , , cord-005453-4057qib7 12641 22 and and CC cord-005453-4057qib7 12641 23 resulted result VBD cord-005453-4057qib7 12641 24 in in IN cord-005453-4057qib7 12641 25 decreased decrease VBN cord-005453-4057qib7 12641 26 PFS PFS NNP cord-005453-4057qib7 12641 27 ) ) -RRB- cord-005453-4057qib7 12641 28 , , , cord-005453-4057qib7 12641 29 p=0.001 p=0.001 NNP cord-005453-4057qib7 12641 30 ) ) -RRB- cord-005453-4057qib7 12641 31 . . . cord-005453-4057qib7 12642 1 The the DT cord-005453-4057qib7 12642 2 high high JJ cord-005453-4057qib7 12642 3 - - HYPH cord-005453-4057qib7 12642 4 risk risk NN cord-005453-4057qib7 12642 5 cytogenetic cytogenetic NN cord-005453-4057qib7 12642 6 at at IN cord-005453-4057qib7 12642 7 diagnosis diagnosis NN cord-005453-4057qib7 12642 8 showed show VBD cord-005453-4057qib7 12642 9 no no DT cord-005453-4057qib7 12642 10 impact impact NN cord-005453-4057qib7 12642 11 on on IN cord-005453-4057qib7 12642 12 survival survival NN cord-005453-4057qib7 12642 13 . . . cord-005453-4057qib7 12643 1 The the DT cord-005453-4057qib7 12643 2 CIs ci NNS cord-005453-4057qib7 12643 3 of of IN cord-005453-4057qib7 12643 4 acute acute JJ cord-005453-4057qib7 12643 5 ( ( -LRB- cord-005453-4057qib7 12643 6 grade grade NN cord-005453-4057qib7 12643 7 II II NNP cord-005453-4057qib7 12643 8 - - HYPH cord-005453-4057qib7 12643 9 IV IV NNP cord-005453-4057qib7 12643 10 ) ) -RRB- cord-005453-4057qib7 12643 11 at at IN cord-005453-4057qib7 12643 12 day day NN cord-005453-4057qib7 12643 13 +100 +100 NNS cord-005453-4057qib7 12643 14 and and CC cord-005453-4057qib7 12643 15 chronic chronic JJ cord-005453-4057qib7 12643 16 GvHD gvhd NN cord-005453-4057qib7 12643 17 at at IN cord-005453-4057qib7 12643 18 2 2 CD cord-005453-4057qib7 12643 19 years year NNS cord-005453-4057qib7 12643 20 were be VBD cord-005453-4057qib7 12643 21 26 26 CD cord-005453-4057qib7 12643 22 % % NN cord-005453-4057qib7 12643 23 ( ( -LRB- cord-005453-4057qib7 12643 24 10 10 CD cord-005453-4057qib7 12643 25 - - SYM cord-005453-4057qib7 12643 26 42 42 CD cord-005453-4057qib7 12643 27 % % NN cord-005453-4057qib7 12643 28 ) ) -RRB- cord-005453-4057qib7 12643 29 and and CC cord-005453-4057qib7 12643 30 48 48 CD cord-005453-4057qib7 12643 31 % % NN cord-005453-4057qib7 12643 32 ( ( -LRB- cord-005453-4057qib7 12643 33 26 26 CD cord-005453-4057qib7 12643 34 - - SYM cord-005453-4057qib7 12643 35 70 70 CD cord-005453-4057qib7 12643 36 % % NN cord-005453-4057qib7 12643 37 ) ) -RRB- cord-005453-4057qib7 12643 38 , , , cord-005453-4057qib7 12643 39 respectively respectively RB cord-005453-4057qib7 12643 40 . . . cord-005453-4057qib7 12644 1 Absence absence NN cord-005453-4057qib7 12644 2 of of IN cord-005453-4057qib7 12644 3 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 12644 4 medication medication NN cord-005453-4057qib7 12644 5 beside beside IN cord-005453-4057qib7 12644 6 post post NNP cord-005453-4057qib7 12644 7 - - NNP cord-005453-4057qib7 12644 8 Cy Cy NNP cord-005453-4057qib7 12644 9 was be VBD cord-005453-4057qib7 12644 10 associated associate VBN cord-005453-4057qib7 12644 11 with with IN cord-005453-4057qib7 12644 12 poorer poor JJR cord-005453-4057qib7 12644 13 OS OS NNP cord-005453-4057qib7 12644 14 ) ) -RRB- cord-005453-4057qib7 12644 15 , , , cord-005453-4057qib7 12644 16 p=0.01 p=0.01 NNP cord-005453-4057qib7 12644 17 ) ) -RRB- cord-005453-4057qib7 12644 18 . . . cord-005453-4057qib7 12645 1 Conclusions conclusion NNS cord-005453-4057qib7 12645 2 : : : cord-005453-4057qib7 12646 1 The the DT cord-005453-4057qib7 12646 2 conditioning conditioning NN cord-005453-4057qib7 12646 3 with with IN cord-005453-4057qib7 12646 4 BU BU NNP cord-005453-4057qib7 12646 5 , , , cord-005453-4057qib7 12646 6 TT TT NNP cord-005453-4057qib7 12646 7 and and CC cord-005453-4057qib7 12646 8 post post AFX cord-005453-4057qib7 12646 9 - - JJ cord-005453-4057qib7 12646 10 Cy Cy NNP cord-005453-4057qib7 12646 11 leads lead VBZ cord-005453-4057qib7 12646 12 to to IN cord-005453-4057qib7 12646 13 a a DT cord-005453-4057qib7 12646 14 favorable favorable JJ cord-005453-4057qib7 12646 15 PFS PFS NNP cord-005453-4057qib7 12646 16 and and CC cord-005453-4057qib7 12646 17 OS OS NNP cord-005453-4057qib7 12646 18 due due JJ cord-005453-4057qib7 12646 19 to to IN cord-005453-4057qib7 12646 20 low low JJ cord-005453-4057qib7 12646 21 incidences incidence NNS cord-005453-4057qib7 12646 22 of of IN cord-005453-4057qib7 12646 23 relapse relapse NN cord-005453-4057qib7 12646 24 and and CC cord-005453-4057qib7 12646 25 NRM NRM NNP cord-005453-4057qib7 12646 26 for for IN cord-005453-4057qib7 12646 27 patients patient NNS cord-005453-4057qib7 12646 28 with with IN cord-005453-4057qib7 12646 29 multiple multiple JJ cord-005453-4057qib7 12646 30 myeloma myeloma NN cord-005453-4057qib7 12646 31 relapsing relapse VBG cord-005453-4057qib7 12646 32 after after IN cord-005453-4057qib7 12646 33 autografting autografte VBG cord-005453-4057qib7 12646 34 . . . cord-005453-4057qib7 12647 1 Disclosure disclosure NN cord-005453-4057qib7 12647 2 : : : cord-005453-4057qib7 12647 3 Nothing nothing NN cord-005453-4057qib7 12647 4 to to TO cord-005453-4057qib7 12647 5 declare declare VB cord-005453-4057qib7 12647 6 Methods method NNS cord-005453-4057qib7 12647 7 : : : cord-005453-4057qib7 12647 8 Between between IN cord-005453-4057qib7 12647 9 January January NNP cord-005453-4057qib7 12647 10 2011 2011 CD cord-005453-4057qib7 12647 11 and and CC cord-005453-4057qib7 12647 12 May May NNP cord-005453-4057qib7 12647 13 2017 2017 CD cord-005453-4057qib7 12647 14 , , , cord-005453-4057qib7 12647 15 we -PRON- PRP cord-005453-4057qib7 12647 16 included include VBD cord-005453-4057qib7 12647 17 51 51 CD cord-005453-4057qib7 12647 18 patients patient NNS cord-005453-4057qib7 12647 19 with with IN cord-005453-4057qib7 12647 20 MM MM NNP cord-005453-4057qib7 12647 21 who who WP cord-005453-4057qib7 12647 22 underwent undergo VBD cord-005453-4057qib7 12647 23 ASCT ASCT NNP cord-005453-4057qib7 12647 24 and and CC cord-005453-4057qib7 12647 25 received receive VBD cord-005453-4057qib7 12647 26 Bortezomib Bortezomib NNP cord-005453-4057qib7 12647 27 / / SYM cord-005453-4057qib7 12647 28 Lenalidomide Lenalidomide NNP cord-005453-4057qib7 12647 29 / / SYM cord-005453-4057qib7 12647 30 Dexamethasone Dexamethasone NNP cord-005453-4057qib7 12647 31 ( ( -LRB- cord-005453-4057qib7 12647 32 VRD VRD NNP cord-005453-4057qib7 12647 33 ) ) -RRB- cord-005453-4057qib7 12647 34 consolidation consolidation NN cord-005453-4057qib7 12647 35 and and CC cord-005453-4057qib7 12647 36 maintenance maintenance NN cord-005453-4057qib7 12647 37 therapy therapy NN cord-005453-4057qib7 12647 38 , , , cord-005453-4057qib7 12647 39 mainly mainly RB cord-005453-4057qib7 12647 40 lenalidomide(R lenalidomide(r JJ cord-005453-4057qib7 12647 41 ) ) -RRB- cord-005453-4057qib7 12648 1 10mg 10mg NNP cord-005453-4057qib7 12648 2 / / SYM cord-005453-4057qib7 12648 3 day day NN cord-005453-4057qib7 12648 4 for for IN cord-005453-4057qib7 12648 5 21 21 CD cord-005453-4057qib7 12648 6 days day NNS cord-005453-4057qib7 12648 7 every every DT cord-005453-4057qib7 12648 8 28 28 CD cord-005453-4057qib7 12648 9 days day NNS cord-005453-4057qib7 12648 10 . . . cord-005453-4057qib7 12649 1 Results result NNS cord-005453-4057qib7 12649 2 : : : cord-005453-4057qib7 12650 1 The the DT cord-005453-4057qib7 12650 2 median median JJ cord-005453-4057qib7 12650 3 age age NN cord-005453-4057qib7 12650 4 at at IN cord-005453-4057qib7 12650 5 transplant transplant NN cord-005453-4057qib7 12650 6 was be VBD cord-005453-4057qib7 12650 7 55 55 CD cord-005453-4057qib7 12650 8 years year NNS cord-005453-4057qib7 12650 9 ( ( -LRB- cord-005453-4057qib7 12650 10 46 46 CD cord-005453-4057qib7 12650 11 - - SYM cord-005453-4057qib7 12650 12 75 75 CD cord-005453-4057qib7 12650 13 ) ) -RRB- cord-005453-4057qib7 12650 14 . . . cord-005453-4057qib7 12651 1 Forty forty CD cord-005453-4057qib7 12651 2 - - HYPH cord-005453-4057qib7 12651 3 six six CD cord-005453-4057qib7 12651 4 ( ( -LRB- cord-005453-4057qib7 12651 5 90 90 CD cord-005453-4057qib7 12651 6 % % NN cord-005453-4057qib7 12651 7 ) ) -RRB- cord-005453-4057qib7 12651 8 of of IN cord-005453-4057qib7 12651 9 patients patient NNS cord-005453-4057qib7 12651 10 received receive VBD cord-005453-4057qib7 12651 11 R r NN cord-005453-4057qib7 12651 12 maintenance maintenance NN cord-005453-4057qib7 12651 13 , , , cord-005453-4057qib7 12651 14 3 3 CD cord-005453-4057qib7 12651 15 patients patient NNS cord-005453-4057qib7 12651 16 received receive VBD cord-005453-4057qib7 12651 17 VRD VRD NNP cord-005453-4057qib7 12651 18 maintenance maintenance NN cord-005453-4057qib7 12651 19 for for IN cord-005453-4057qib7 12651 20 higher high JJR cord-005453-4057qib7 12651 21 risk risk NN cord-005453-4057qib7 12651 22 features feature NNS cord-005453-4057qib7 12651 23 . . . cord-005453-4057qib7 12652 1 Median median JJ cord-005453-4057qib7 12652 2 duration duration NN cord-005453-4057qib7 12652 3 of of IN cord-005453-4057qib7 12652 4 R r NN cord-005453-4057qib7 12652 5 maintenance maintenance NN cord-005453-4057qib7 12652 6 was be VBD cord-005453-4057qib7 12652 7 22 22 CD cord-005453-4057qib7 12652 8 months month NNS cord-005453-4057qib7 12652 9 . . . cord-005453-4057qib7 12653 1 R r NN cord-005453-4057qib7 12653 2 dose dose NN cord-005453-4057qib7 12653 3 was be VBD cord-005453-4057qib7 12653 4 changed change VBN cord-005453-4057qib7 12653 5 for for IN cord-005453-4057qib7 12653 6 toxicity toxicity NN cord-005453-4057qib7 12653 7 ( ( -LRB- cord-005453-4057qib7 12653 8 grade grade NN cord-005453-4057qib7 12653 9 I I NNP cord-005453-4057qib7 12653 10 - - HYPH cord-005453-4057qib7 12653 11 II II NNP cord-005453-4057qib7 12653 12 ) ) -RRB- cord-005453-4057qib7 12653 13 in in IN cord-005453-4057qib7 12653 14 17 17 CD cord-005453-4057qib7 12653 15 ( ( -LRB- cord-005453-4057qib7 12653 16 33 33 CD cord-005453-4057qib7 12653 17 % % NN cord-005453-4057qib7 12653 18 ) ) -RRB- cord-005453-4057qib7 12653 19 patients patient NNS cord-005453-4057qib7 12653 20 . . . cord-005453-4057qib7 12654 1 Twenty twenty CD cord-005453-4057qib7 12654 2 - - HYPH cord-005453-4057qib7 12654 3 nine nine CD cord-005453-4057qib7 12654 4 ( ( -LRB- cord-005453-4057qib7 12654 5 57 57 CD cord-005453-4057qib7 12654 6 % % NN cord-005453-4057qib7 12654 7 ) ) -RRB- cord-005453-4057qib7 12654 8 patients patient NNS cord-005453-4057qib7 12654 9 relapsed relapse VBD cord-005453-4057qib7 12654 10 : : : cord-005453-4057qib7 12654 11 13 13 CD cord-005453-4057qib7 12654 12 ( ( -LRB- cord-005453-4057qib7 12654 13 25 25 CD cord-005453-4057qib7 12654 14 % % NN cord-005453-4057qib7 12654 15 ) ) -RRB- cord-005453-4057qib7 12654 16 patients patient NNS cord-005453-4057qib7 12654 17 were be VBD cord-005453-4057qib7 12654 18 shifted shift VBN cord-005453-4057qib7 12654 19 to to IN cord-005453-4057qib7 12654 20 different different JJ cord-005453-4057qib7 12654 21 treatment treatment NN cord-005453-4057qib7 12654 22 protocols protocol NNS cord-005453-4057qib7 12654 23 ( ( -LRB- cord-005453-4057qib7 12654 24 treatment treatment NN cord-005453-4057qib7 12654 25 change change NN cord-005453-4057qib7 12654 26 ) ) -RRB- cord-005453-4057qib7 12654 27 . . . cord-005453-4057qib7 12655 1 6 6 CD cord-005453-4057qib7 12655 2 patients patient NNS cord-005453-4057qib7 12655 3 ( ( -LRB- cord-005453-4057qib7 12655 4 11 11 CD cord-005453-4057qib7 12655 5 % % NN cord-005453-4057qib7 12655 6 ) ) -RRB- cord-005453-4057qib7 12655 7 were be VBD cord-005453-4057qib7 12655 8 kept keep VBN cord-005453-4057qib7 12655 9 on on IN cord-005453-4057qib7 12655 10 the the DT cord-005453-4057qib7 12655 11 same same JJ cord-005453-4057qib7 12655 12 R r NN cord-005453-4057qib7 12655 13 maintenance maintenance NN cord-005453-4057qib7 12655 14 ( ( -LRB- cord-005453-4057qib7 12655 15 observation observation NN cord-005453-4057qib7 12655 16 group group NN cord-005453-4057qib7 12655 17 ) ) -RRB- cord-005453-4057qib7 12655 18 and and CC cord-005453-4057qib7 12655 19 10 10 CD cord-005453-4057qib7 12655 20 ( ( -LRB- cord-005453-4057qib7 12655 21 20 20 CD cord-005453-4057qib7 12655 22 % % NN cord-005453-4057qib7 12655 23 ) ) -RRB- cord-005453-4057qib7 12655 24 patients patient NNS cord-005453-4057qib7 12655 25 had have VBD cord-005453-4057qib7 12655 26 increased increase VBN cord-005453-4057qib7 12655 27 lenalidomide lenalidomide RB cord-005453-4057qib7 12655 28 dose dose NN cord-005453-4057qib7 12655 29 with with IN cord-005453-4057qib7 12655 30 dexamethasone dexamethasone NN cord-005453-4057qib7 12655 31 ( ( -LRB- cord-005453-4057qib7 12655 32 R/ R/ NNP cord-005453-4057qib7 12655 33 D D NNP cord-005453-4057qib7 12655 34 group group NN cord-005453-4057qib7 12655 35 ) ) -RRB- cord-005453-4057qib7 12655 36 . . . cord-005453-4057qib7 12656 1 6 6 CD cord-005453-4057qib7 12656 2 patients patient NNS cord-005453-4057qib7 12656 3 ( ( -LRB- cord-005453-4057qib7 12656 4 37 37 CD cord-005453-4057qib7 12656 5 % % NN cord-005453-4057qib7 12656 6 ) ) -RRB- cord-005453-4057qib7 12656 7 of of IN cord-005453-4057qib7 12656 8 the the DT cord-005453-4057qib7 12656 9 last last JJ cord-005453-4057qib7 12656 10 2 2 CD cord-005453-4057qib7 12656 11 groups group NNS cord-005453-4057qib7 12656 12 required require VBD cord-005453-4057qib7 12656 13 change change NN cord-005453-4057qib7 12656 14 of of IN cord-005453-4057qib7 12656 15 treatment treatment NN cord-005453-4057qib7 12656 16 later later RB cord-005453-4057qib7 12656 17 . . . cord-005453-4057qib7 12657 1 The the DT cord-005453-4057qib7 12657 2 median median NN cord-005453-4057qib7 12657 3 follow follow VBP cord-005453-4057qib7 12657 4 up up RP cord-005453-4057qib7 12657 5 was be VBD cord-005453-4057qib7 12657 6 38 38 CD cord-005453-4057qib7 12657 7 months month NNS cord-005453-4057qib7 12657 8 . . . cord-005453-4057qib7 12658 1 Median median JJ cord-005453-4057qib7 12658 2 TNT TNT NNP cord-005453-4057qib7 12658 3 was be VBD cord-005453-4057qib7 12658 4 32 32 CD cord-005453-4057qib7 12658 5 months month NNS cord-005453-4057qib7 12658 6 ( ( -LRB- cord-005453-4057qib7 12658 7 7 7 CD cord-005453-4057qib7 12658 8 - - SYM cord-005453-4057qib7 12658 9 62 62 CD cord-005453-4057qib7 12658 10 ) ) -RRB- cord-005453-4057qib7 12658 11 . . . cord-005453-4057qib7 12659 1 At at IN cord-005453-4057qib7 12659 2 2 2 CD cord-005453-4057qib7 12659 3 years year NNS cord-005453-4057qib7 12659 4 , , , cord-005453-4057qib7 12659 5 the the DT cord-005453-4057qib7 12659 6 estimated estimate VBN cord-005453-4057qib7 12659 7 PFS PFS NNP cord-005453-4057qib7 12659 8 and and CC cord-005453-4057qib7 12659 9 OS OS NNP cord-005453-4057qib7 12659 10 were be VBD cord-005453-4057qib7 12659 11 39 39 CD cord-005453-4057qib7 12659 12 % % NN cord-005453-4057qib7 12659 13 and and CC cord-005453-4057qib7 12659 14 97.5 97.5 CD cord-005453-4057qib7 12659 15 % % NN cord-005453-4057qib7 12659 16 respectively respectively RB cord-005453-4057qib7 12659 17 . . . cord-005453-4057qib7 12660 1 The the DT cord-005453-4057qib7 12660 2 median median JJ cord-005453-4057qib7 12660 3 OS OS NNP cord-005453-4057qib7 12660 4 and and CC cord-005453-4057qib7 12660 5 PFS2 PFS2 NNP cord-005453-4057qib7 12660 6 ( ( -LRB- cord-005453-4057qib7 12660 7 from from IN cord-005453-4057qib7 12660 8 change change NN cord-005453-4057qib7 12660 9 of of IN cord-005453-4057qib7 12660 10 therapy therapy NN cord-005453-4057qib7 12660 11 ) ) -RRB- cord-005453-4057qib7 12660 12 were be VBD cord-005453-4057qib7 12660 13 54 54 CD cord-005453-4057qib7 12660 14 and and CC cord-005453-4057qib7 12660 15 29 29 CD cord-005453-4057qib7 12660 16 months month NNS cord-005453-4057qib7 12660 17 for for IN cord-005453-4057qib7 12660 18 patients patient NNS cord-005453-4057qib7 12660 19 in in IN cord-005453-4057qib7 12660 20 the the DT cord-005453-4057qib7 12660 21 observation observation NN cord-005453-4057qib7 12660 22 group group NN cord-005453-4057qib7 12660 23 , , , cord-005453-4057qib7 12660 24 versus versus IN cord-005453-4057qib7 12660 25 52 52 CD cord-005453-4057qib7 12660 26 and and CC cord-005453-4057qib7 12660 27 27 27 CD cord-005453-4057qib7 12660 28 months month NNS cord-005453-4057qib7 12660 29 in in IN cord-005453-4057qib7 12660 30 the the DT cord-005453-4057qib7 12660 31 R r NN cord-005453-4057qib7 12660 32 / / SYM cord-005453-4057qib7 12660 33 D d NN cord-005453-4057qib7 12660 34 group group NN cord-005453-4057qib7 12660 35 , , , cord-005453-4057qib7 12660 36 and and CC cord-005453-4057qib7 12660 37 45 45 CD cord-005453-4057qib7 12660 38 and and CC cord-005453-4057qib7 12660 39 33 33 CD cord-005453-4057qib7 12660 40 months month NNS cord-005453-4057qib7 12660 41 with with IN cord-005453-4057qib7 12660 42 treatment treatment NN cord-005453-4057qib7 12660 43 change change NN cord-005453-4057qib7 12660 44 , , , cord-005453-4057qib7 12660 45 respectively respectively RB cord-005453-4057qib7 12660 46 . . . cord-005453-4057qib7 12661 1 No no DT cord-005453-4057qib7 12661 2 statistically statistically RB cord-005453-4057qib7 12661 3 significant significant JJ cord-005453-4057qib7 12661 4 difference difference NN cord-005453-4057qib7 12661 5 was be VBD cord-005453-4057qib7 12661 6 noted note VBN cord-005453-4057qib7 12661 7 . . . cord-005453-4057qib7 12662 1 Conclusions conclusion NNS cord-005453-4057qib7 12662 2 : : : cord-005453-4057qib7 12663 1 Our -PRON- PRP$ cord-005453-4057qib7 12663 2 small small JJ cord-005453-4057qib7 12663 3 monocentric monocentric JJ cord-005453-4057qib7 12663 4 study study NN cord-005453-4057qib7 12663 5 is be VBZ cord-005453-4057qib7 12663 6 limited limit VBN cord-005453-4057qib7 12663 7 by by IN cord-005453-4057qib7 12663 8 its -PRON- PRP$ cord-005453-4057qib7 12663 9 retrospective retrospective JJ cord-005453-4057qib7 12663 10 design design NN cord-005453-4057qib7 12663 11 and and CC cord-005453-4057qib7 12663 12 small small JJ cord-005453-4057qib7 12663 13 sample sample NN cord-005453-4057qib7 12663 14 size size NN cord-005453-4057qib7 12663 15 . . . cord-005453-4057qib7 12664 1 However however RB cord-005453-4057qib7 12664 2 , , , cord-005453-4057qib7 12664 3 it -PRON- PRP cord-005453-4057qib7 12664 4 suggests suggest VBZ cord-005453-4057qib7 12664 5 that that IN cord-005453-4057qib7 12664 6 increasing increase VBG cord-005453-4057qib7 12664 7 lenalidomide lenalidomide JJ cord-005453-4057qib7 12664 8 dose dose NN cord-005453-4057qib7 12664 9 as as RB cord-005453-4057qib7 12664 10 well well RB cord-005453-4057qib7 12664 11 as as IN cord-005453-4057qib7 12664 12 adding add VBG cord-005453-4057qib7 12664 13 dexamethasone dexamethasone NN cord-005453-4057qib7 12664 14 in in IN cord-005453-4057qib7 12664 15 selected select VBN cord-005453-4057qib7 12664 16 patients patient NNS cord-005453-4057qib7 12664 17 can can MD cord-005453-4057qib7 12664 18 postpone postpone VB cord-005453-4057qib7 12664 19 change change NN cord-005453-4057qib7 12664 20 to to IN cord-005453-4057qib7 12664 21 different different JJ cord-005453-4057qib7 12664 22 lines line NNS cord-005453-4057qib7 12664 23 of of IN cord-005453-4057qib7 12664 24 treatment treatment NN cord-005453-4057qib7 12664 25 without without IN cord-005453-4057qib7 12664 26 affecting affect VBG cord-005453-4057qib7 12664 27 survival survival NN cord-005453-4057qib7 12664 28 . . . cord-005453-4057qib7 12665 1 Disclosure disclosure NN cord-005453-4057qib7 12665 2 : : : cord-005453-4057qib7 12665 3 Nothing nothing NN cord-005453-4057qib7 12665 4 to to TO cord-005453-4057qib7 12665 5 declare declare VB cord-005453-4057qib7 12665 6 Can Can MD cord-005453-4057qib7 12665 7 the the DT cord-005453-4057qib7 12665 8 drugs drug NNS cord-005453-4057qib7 12665 9 used use VBN cord-005453-4057qib7 12665 10 before before IN cord-005453-4057qib7 12665 11 autologous autologous JJ cord-005453-4057qib7 12665 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 12665 13 stem stem NN cord-005453-4057qib7 12665 14 cell cell NN cord-005453-4057qib7 12665 15 transplantation transplantation NN cord-005453-4057qib7 12665 16 have have VBP cord-005453-4057qib7 12665 17 impact impact NN cord-005453-4057qib7 12665 18 on on IN cord-005453-4057qib7 12665 19 CMV CMV NNP cord-005453-4057qib7 12665 20 reactivation reactivation NN cord-005453-4057qib7 12665 21 that that WDT cord-005453-4057qib7 12665 22 results result VBZ cord-005453-4057qib7 12665 23 in in IN cord-005453-4057qib7 12665 24 decreased decrease VBN cord-005453-4057qib7 12665 25 os os NN cord-005453-4057qib7 12665 26 in in IN cord-005453-4057qib7 12665 27 myeloma myeloma NN cord-005453-4057qib7 12665 28 patients patient NNS cord-005453-4057qib7 12665 29 after after IN cord-005453-4057qib7 12665 30 ASCT ASCT NNP cord-005453-4057qib7 12665 31 ? ? . cord-005453-4057qib7 12666 1 more more RBR cord-005453-4057qib7 12666 2 intensive intensive JJ cord-005453-4057qib7 12666 3 treatment treatment NN cord-005453-4057qib7 12666 4 regimens regimen NNS cord-005453-4057qib7 12666 5 , , , cord-005453-4057qib7 12666 6 such such JJ cord-005453-4057qib7 12666 7 as as IN cord-005453-4057qib7 12666 8 proteasome proteasome NN cord-005453-4057qib7 12666 9 inhibitors inhibitor NNS cord-005453-4057qib7 12666 10 ( ( -LRB- cord-005453-4057qib7 12666 11 PI PI NNP cord-005453-4057qib7 12666 12 ) ) -RRB- cord-005453-4057qib7 12666 13 and/or and/or CC cord-005453-4057qib7 12666 14 immunomodulatory immunomodulatory NNP cord-005453-4057qib7 12666 15 ( ( -LRB- cord-005453-4057qib7 12666 16 IMID IMID NNP cord-005453-4057qib7 12666 17 ) ) -RRB- cord-005453-4057qib7 12666 18 agents agent NNS cord-005453-4057qib7 12666 19 . . . cord-005453-4057qib7 12667 1 We -PRON- PRP cord-005453-4057qib7 12667 2 performed perform VBD cord-005453-4057qib7 12667 3 a a DT cord-005453-4057qib7 12667 4 retrospective retrospective JJ cord-005453-4057qib7 12667 5 , , , cord-005453-4057qib7 12667 6 single single JJ cord-005453-4057qib7 12667 7 center center NN cord-005453-4057qib7 12667 8 study study NN cord-005453-4057qib7 12667 9 to to TO cord-005453-4057qib7 12667 10 evaluate evaluate VB cord-005453-4057qib7 12667 11 the the DT cord-005453-4057qib7 12667 12 incidence incidence NN cord-005453-4057qib7 12667 13 , , , cord-005453-4057qib7 12667 14 risk risk NN cord-005453-4057qib7 12667 15 factors factor NNS cord-005453-4057qib7 12667 16 , , , cord-005453-4057qib7 12667 17 and and CC cord-005453-4057qib7 12667 18 outcomes outcome NNS cord-005453-4057qib7 12667 19 of of IN cord-005453-4057qib7 12667 20 CMV CMV NNP cord-005453-4057qib7 12667 21 infection infection NN cord-005453-4057qib7 12667 22 in in IN cord-005453-4057qib7 12667 23 patients patient NNS cord-005453-4057qib7 12667 24 with with IN cord-005453-4057qib7 12667 25 MM MM NNP cord-005453-4057qib7 12667 26 who who WP cord-005453-4057qib7 12667 27 underwent undergo VBD cord-005453-4057qib7 12667 28 ASCT ASCT NNP cord-005453-4057qib7 12667 29 with with IN cord-005453-4057qib7 12667 30 a a DT cord-005453-4057qib7 12667 31 high high JJ cord-005453-4057qib7 12667 32 - - HYPH cord-005453-4057qib7 12667 33 dose dose NN cord-005453-4057qib7 12667 34 melphalan melphalan NN cord-005453-4057qib7 12667 35 - - HYPH cord-005453-4057qib7 12667 36 based base VBN cord-005453-4057qib7 12667 37 regimen regimen NN cord-005453-4057qib7 12667 38 . . . cord-005453-4057qib7 12668 1 Methods method NNS cord-005453-4057qib7 12668 2 : : : cord-005453-4057qib7 12669 1 This this DT cord-005453-4057qib7 12669 2 study study NN cord-005453-4057qib7 12669 3 involved involve VBD cord-005453-4057qib7 12669 4 a a DT cord-005453-4057qib7 12669 5 retrospective retrospective JJ cord-005453-4057qib7 12669 6 review review NN cord-005453-4057qib7 12669 7 of of IN cord-005453-4057qib7 12669 8 all all DT cord-005453-4057qib7 12669 9 patients patient NNS cord-005453-4057qib7 12669 10 with with IN cord-005453-4057qib7 12669 11 who who WP cord-005453-4057qib7 12669 12 underwent undergo VBD cord-005453-4057qib7 12669 13 ASCT ASCT NNP cord-005453-4057qib7 12669 14 between between IN cord-005453-4057qib7 12669 15 January January NNP cord-005453-4057qib7 12669 16 2015 2015 CD cord-005453-4057qib7 12669 17 and and CC cord-005453-4057qib7 12669 18 November November NNP cord-005453-4057qib7 12669 19 2018 2018 CD cord-005453-4057qib7 12669 20 at at IN cord-005453-4057qib7 12669 21 our -PRON- PRP$ cord-005453-4057qib7 12669 22 stem stem NN cord-005453-4057qib7 12669 23 cell cell NN cord-005453-4057qib7 12669 24 transplantation transplantation NN cord-005453-4057qib7 12669 25 center center NN cord-005453-4057qib7 12669 26 . . . cord-005453-4057qib7 12670 1 A a DT cord-005453-4057qib7 12670 2 total total NN cord-005453-4057qib7 12670 3 of of IN cord-005453-4057qib7 12670 4 144 144 CD cord-005453-4057qib7 12670 5 consecutive consecutive JJ cord-005453-4057qib7 12670 6 adult adult NN cord-005453-4057qib7 12670 7 patients patient NNS cord-005453-4057qib7 12670 8 with with IN cord-005453-4057qib7 12670 9 a a DT cord-005453-4057qib7 12670 10 diagnosis diagnosis NN cord-005453-4057qib7 12670 11 of of IN cord-005453-4057qib7 12670 12 MM MM NNP cord-005453-4057qib7 12670 13 ( ( -LRB- cord-005453-4057qib7 12670 14 median median JJ cord-005453-4057qib7 12670 15 age age NN cord-005453-4057qib7 12670 16 at at IN cord-005453-4057qib7 12670 17 diagnosis diagnosis NN cord-005453-4057qib7 12670 18 : : : cord-005453-4057qib7 12670 19 58 58 CD cord-005453-4057qib7 12670 20 , , , cord-005453-4057qib7 12670 21 range range NN cord-005453-4057qib7 12670 22 : : : cord-005453-4057qib7 12670 23 35 35 CD cord-005453-4057qib7 12670 24 - - SYM cord-005453-4057qib7 12670 25 77 77 CD cord-005453-4057qib7 12670 26 ) ) -RRB- cord-005453-4057qib7 12670 27 underwent undergo VBD cord-005453-4057qib7 12670 28 ASCT ASCT NNP cord-005453-4057qib7 12670 29 following follow VBG cord-005453-4057qib7 12670 30 induction induction NN cord-005453-4057qib7 12670 31 treatment treatment NN cord-005453-4057qib7 12670 32 with with IN cord-005453-4057qib7 12670 33 novel novel JJ cord-005453-4057qib7 12670 34 agents agent NNS cord-005453-4057qib7 12670 35 ( ( -LRB- cord-005453-4057qib7 12670 36 PIs pi NNS cord-005453-4057qib7 12670 37 and/or and/or CC cord-005453-4057qib7 12670 38 IMIDs IMIDs NNP cord-005453-4057qib7 12670 39 ) ) -RRB- cord-005453-4057qib7 12670 40 . . . cord-005453-4057qib7 12671 1 All all DT cord-005453-4057qib7 12671 2 patients patient NNS cord-005453-4057qib7 12671 3 received receive VBD cord-005453-4057qib7 12671 4 antiviral antiviral JJ cord-005453-4057qib7 12671 5 prophylaxis prophylaxis NN cord-005453-4057qib7 12671 6 with with IN cord-005453-4057qib7 12671 7 acyclovir acyclovir NNP cord-005453-4057qib7 12671 8 600 600 CD cord-005453-4057qib7 12671 9 mg mg NNP cord-005453-4057qib7 12671 10 / / SYM cord-005453-4057qib7 12671 11 day day NN cord-005453-4057qib7 12671 12 ( ( -LRB- cord-005453-4057qib7 12671 13 n=104 n=104 NNP cord-005453-4057qib7 12671 14 ) ) -RRB- cord-005453-4057qib7 12671 15 or or CC cord-005453-4057qib7 12671 16 valaganciclovir valaganciclovir VBZ cord-005453-4057qib7 12671 17 1000 1000 CD cord-005453-4057qib7 12671 18 mg mg NNP cord-005453-4057qib7 12671 19 / / SYM cord-005453-4057qib7 12671 20 day day NN cord-005453-4057qib7 12671 21 ( ( -LRB- cord-005453-4057qib7 12671 22 n=36 n=36 NNS cord-005453-4057qib7 12671 23 ) ) -RRB- cord-005453-4057qib7 12671 24 . . . cord-005453-4057qib7 12672 1 Results result NNS cord-005453-4057qib7 12672 2 : : : cord-005453-4057qib7 12673 1 Baseline baseline JJ cord-005453-4057qib7 12673 2 patient patient JJ cord-005453-4057qib7 12673 3 characteristics characteristic NNS cord-005453-4057qib7 12673 4 , , , cord-005453-4057qib7 12673 5 according accord VBG cord-005453-4057qib7 12673 6 to to IN cord-005453-4057qib7 12673 7 induction induction NN cord-005453-4057qib7 12673 8 treatment treatment NN cord-005453-4057qib7 12673 9 , , , cord-005453-4057qib7 12673 10 are be VBP cord-005453-4057qib7 12673 11 summarized summarize VBN cord-005453-4057qib7 12673 12 in in IN cord-005453-4057qib7 12673 13 Table- Table- NNP cord-005453-4057qib7 12673 14 1 1 CD cord-005453-4057qib7 12673 15 . . . cord-005453-4057qib7 12674 1 One one CD cord-005453-4057qib7 12674 2 hundred hundred CD cord-005453-4057qib7 12674 3 - - HYPH cord-005453-4057qib7 12674 4 five five CD cord-005453-4057qib7 12674 5 of of IN cord-005453-4057qib7 12674 6 the the DT cord-005453-4057qib7 12674 7 144 144 CD cord-005453-4057qib7 12674 8 patients patient NNS cord-005453-4057qib7 12674 9 ( ( -LRB- cord-005453-4057qib7 12674 10 97.2 97.2 CD cord-005453-4057qib7 12674 11 % % NN cord-005453-4057qib7 12674 12 ) ) -RRB- cord-005453-4057qib7 12674 13 were be VBD cord-005453-4057qib7 12674 14 CMV CMV NNP cord-005453-4057qib7 12674 15 IgGpositive IgGpositive NNP cord-005453-4057qib7 12674 16 before before IN cord-005453-4057qib7 12674 17 ASCT ASCT NNP cord-005453-4057qib7 12674 18 . . . cord-005453-4057qib7 12675 1 Overall overall RB cord-005453-4057qib7 12675 2 , , , cord-005453-4057qib7 12675 3 14.6 14.6 CD cord-005453-4057qib7 12675 4 % % NN cord-005453-4057qib7 12675 5 ( ( -LRB- cord-005453-4057qib7 12675 6 n=21 n=21 NNP cord-005453-4057qib7 12675 7 ) ) -RRB- cord-005453-4057qib7 12675 8 of of IN cord-005453-4057qib7 12675 9 CMVseropositive CMVseropositive NNP cord-005453-4057qib7 12675 10 patients patient NNS cord-005453-4057qib7 12675 11 developed develop VBD cord-005453-4057qib7 12675 12 at at IN cord-005453-4057qib7 12675 13 least least JJS cord-005453-4057qib7 12675 14 one one CD cord-005453-4057qib7 12675 15 episode episode NN cord-005453-4057qib7 12675 16 of of IN cord-005453-4057qib7 12675 17 CMV CMV NNP cord-005453-4057qib7 12675 18 viremia viremia NN cord-005453-4057qib7 12675 19 ( ( -LRB- cord-005453-4057qib7 12675 20 CMV CMV NNP cord-005453-4057qib7 12675 21 DNA DNA NNP cord-005453-4057qib7 12675 22 > > XX cord-005453-4057qib7 12675 23 100 100 CD cord-005453-4057qib7 12675 24 copies copy NNS cord-005453-4057qib7 12675 25 / / SYM cord-005453-4057qib7 12675 26 ml ml NN cord-005453-4057qib7 12675 27 ) ) -RRB- cord-005453-4057qib7 12675 28 after after IN cord-005453-4057qib7 12675 29 a a DT cord-005453-4057qib7 12675 30 median median JJ cord-005453-4057qib7 12675 31 24 24 CD cord-005453-4057qib7 12675 32 months month NNS cord-005453-4057qib7 12675 33 ( ( -LRB- cord-005453-4057qib7 12675 34 range range NN cord-005453-4057qib7 12675 35 ; ; : cord-005453-4057qib7 12675 36 3 3 CD cord-005453-4057qib7 12675 37 - - SYM cord-005453-4057qib7 12675 38 48 48 CD cord-005453-4057qib7 12675 39 mos mo NNS cord-005453-4057qib7 12675 40 ) ) -RRB- cord-005453-4057qib7 12675 41 follow follow NN cord-005453-4057qib7 12675 42 - - HYPH cord-005453-4057qib7 12675 43 up up NN cord-005453-4057qib7 12675 44 . . . cord-005453-4057qib7 12676 1 Persistent persistent JJ cord-005453-4057qib7 12676 2 CMV CMV NNP cord-005453-4057qib7 12676 3 viremia viremia NN cord-005453-4057qib7 12676 4 ( ( -LRB- cord-005453-4057qib7 12676 5 detectable detectable JJ cord-005453-4057qib7 12676 6 CMV CMV NNP cord-005453-4057qib7 12676 7 DNA dna NN cord-005453-4057qib7 12676 8 load load NN cord-005453-4057qib7 12676 9 in in IN cord-005453-4057qib7 12676 10 more more JJR cord-005453-4057qib7 12676 11 than than IN cord-005453-4057qib7 12676 12 2 2 CD cord-005453-4057qib7 12676 13 sequential sequential JJ cord-005453-4057qib7 12676 14 plasma plasma NN cord-005453-4057qib7 12676 15 specimens specimen NNS cord-005453-4057qib7 12676 16 ) ) -RRB- cord-005453-4057qib7 12676 17 occurred occur VBD cord-005453-4057qib7 12676 18 in in IN cord-005453-4057qib7 12676 19 4.9 4.9 CD cord-005453-4057qib7 12676 20 % % NN cord-005453-4057qib7 12676 21 ( ( -LRB- cord-005453-4057qib7 12676 22 7 7 CD cord-005453-4057qib7 12676 23 of of IN cord-005453-4057qib7 12676 24 144 144 CD cord-005453-4057qib7 12676 25 ) ) -RRB- cord-005453-4057qib7 12676 26 of of IN cord-005453-4057qib7 12676 27 the the DT cord-005453-4057qib7 12676 28 seropositive seropositive JJ cord-005453-4057qib7 12676 29 ASCT ASCT NNP cord-005453-4057qib7 12676 30 recipients recipient NNS cord-005453-4057qib7 12676 31 and and CC cord-005453-4057qib7 12676 32 all all DT cord-005453-4057qib7 12676 33 of of IN cord-005453-4057qib7 12676 34 them -PRON- PRP cord-005453-4057qib7 12676 35 were be VBD cord-005453-4057qib7 12676 36 preventive preventive JJ cord-005453-4057qib7 12676 37 treated treat VBN cord-005453-4057qib7 12676 38 with with IN cord-005453-4057qib7 12676 39 ganciclovir ganciclovir NNP cord-005453-4057qib7 12676 40 ( ( -LRB- cord-005453-4057qib7 12676 41 n=5 n=5 NNP cord-005453-4057qib7 12676 42 ) ) -RRB- cord-005453-4057qib7 12676 43 or or CC cord-005453-4057qib7 12676 44 valganciclovir valganciclovir NNP cord-005453-4057qib7 12676 45 ( ( -LRB- cord-005453-4057qib7 12676 46 n=2 n=2 NNS cord-005453-4057qib7 12676 47 ) ) -RRB- cord-005453-4057qib7 12676 48 . . . cord-005453-4057qib7 12677 1 The the DT cord-005453-4057qib7 12677 2 time time NN cord-005453-4057qib7 12677 3 from from IN cord-005453-4057qib7 12677 4 stem stem NN cord-005453-4057qib7 12677 5 cell cell NN cord-005453-4057qib7 12677 6 infusion infusion NN cord-005453-4057qib7 12677 7 to to IN cord-005453-4057qib7 12677 8 the the DT cord-005453-4057qib7 12677 9 development development NN cord-005453-4057qib7 12677 10 of of IN cord-005453-4057qib7 12677 11 CMV CMV NNP cord-005453-4057qib7 12677 12 viremia viremia NN cord-005453-4057qib7 12677 13 ranged range VBD cord-005453-4057qib7 12677 14 from from IN cord-005453-4057qib7 12677 15 3 3 CD cord-005453-4057qib7 12677 16 days day NNS cord-005453-4057qib7 12677 17 to to IN cord-005453-4057qib7 12677 18 48 48 CD cord-005453-4057qib7 12677 19 days day NNS cord-005453-4057qib7 12677 20 . . . cord-005453-4057qib7 12678 1 None none NN cord-005453-4057qib7 12678 2 of of IN cord-005453-4057qib7 12678 3 the the DT cord-005453-4057qib7 12678 4 patients patient NNS cord-005453-4057qib7 12678 5 with with IN cord-005453-4057qib7 12678 6 untreated untreated JJ cord-005453-4057qib7 12678 7 viremia viremia NN cord-005453-4057qib7 12678 8 developed develop VBD cord-005453-4057qib7 12678 9 identifiable identifiable JJ cord-005453-4057qib7 12678 10 CMV CMV NNP cord-005453-4057qib7 12678 11 sequelae sequela NNS cord-005453-4057qib7 12678 12 . . . cord-005453-4057qib7 12679 1 No no DT cord-005453-4057qib7 12679 2 case case NN cord-005453-4057qib7 12679 3 of of IN cord-005453-4057qib7 12679 4 primary primary JJ cord-005453-4057qib7 12679 5 infection infection NN cord-005453-4057qib7 12679 6 in in IN cord-005453-4057qib7 12679 7 seronegative seronegative JJ cord-005453-4057qib7 12679 8 patients patient NNS cord-005453-4057qib7 12679 9 at at IN cord-005453-4057qib7 12679 10 transplant transplant NN cord-005453-4057qib7 12679 11 was be VBD cord-005453-4057qib7 12679 12 observed observe VBN cord-005453-4057qib7 12679 13 . . . cord-005453-4057qib7 12680 1 Adding add VBG cord-005453-4057qib7 12680 2 to to IN cord-005453-4057qib7 12680 3 that that DT cord-005453-4057qib7 12680 4 none none NN cord-005453-4057qib7 12680 5 of of IN cord-005453-4057qib7 12680 6 the the DT cord-005453-4057qib7 12680 7 patients patient NNS cord-005453-4057qib7 12680 8 developed develop VBD cord-005453-4057qib7 12680 9 CMV CMV NNP cord-005453-4057qib7 12680 10 disease disease NN cord-005453-4057qib7 12680 11 post post NN cord-005453-4057qib7 12680 12 ASCT ASCT NNP cord-005453-4057qib7 12680 13 . . . cord-005453-4057qib7 12681 1 If if IN cord-005453-4057qib7 12681 2 we -PRON- PRP cord-005453-4057qib7 12681 3 analyzed analyze VBD cord-005453-4057qib7 12681 4 the the DT cord-005453-4057qib7 12681 5 subgroups subgroup NNS cord-005453-4057qib7 12681 6 of of IN cord-005453-4057qib7 12681 7 patients patient NNS cord-005453-4057qib7 12681 8 according accord VBG cord-005453-4057qib7 12681 9 to to IN cord-005453-4057qib7 12681 10 induction induction NN cord-005453-4057qib7 12681 11 therapy therapy NN cord-005453-4057qib7 12681 12 ( ( -LRB- cord-005453-4057qib7 12681 13 PI pi NN cord-005453-4057qib7 12681 14 - - HYPH cord-005453-4057qib7 12681 15 based base VBN cord-005453-4057qib7 12681 16 , , , cord-005453-4057qib7 12681 17 IMIDs IMIDs NNP cord-005453-4057qib7 12681 18 , , , cord-005453-4057qib7 12681 19 PI+IMID PI+IMID NNP cord-005453-4057qib7 12681 20 ) ) -RRB- cord-005453-4057qib7 12681 21 , , , cord-005453-4057qib7 12681 22 the the DT cord-005453-4057qib7 12681 23 incidence incidence NN cord-005453-4057qib7 12681 24 of of IN cord-005453-4057qib7 12681 25 post post JJ cord-005453-4057qib7 12681 26 - - JJ cord-005453-4057qib7 12681 27 ASCT asct JJ cord-005453-4057qib7 12681 28 CMV CMV NNP cord-005453-4057qib7 12681 29 reactivation reactivation NN cord-005453-4057qib7 12681 30 was be VBD cord-005453-4057qib7 12681 31 higher high JJR cord-005453-4057qib7 12681 32 but but CC cord-005453-4057qib7 12681 33 not not RB cord-005453-4057qib7 12681 34 statistically statistically RB cord-005453-4057qib7 12681 35 significant significant JJ cord-005453-4057qib7 12681 36 , , , cord-005453-4057qib7 12681 37 in in IN cord-005453-4057qib7 12681 38 patients patient NNS cord-005453-4057qib7 12681 39 who who WP cord-005453-4057qib7 12681 40 received receive VBD cord-005453-4057qib7 12681 41 only only RB cord-005453-4057qib7 12681 42 PI PI NNP cord-005453-4057qib7 12681 43 vs vs IN cord-005453-4057qib7 12681 44 PI+IMID PI+IMID NNP cord-005453-4057qib7 12681 45 ( ( -LRB- cord-005453-4057qib7 12681 46 13 13 CD cord-005453-4057qib7 12681 47 ( ( -LRB- cord-005453-4057qib7 12681 48 61.9 61.9 CD cord-005453-4057qib7 12681 49 % % NN cord-005453-4057qib7 12681 50 ) ) -RRB- cord-005453-4057qib7 12681 51 vs vs IN cord-005453-4057qib7 12681 52 8 8 CD cord-005453-4057qib7 12681 53 ( ( -LRB- cord-005453-4057qib7 12681 54 38.1 38.1 CD cord-005453-4057qib7 12681 55 % % NN cord-005453-4057qib7 12681 56 ) ) -RRB- cord-005453-4057qib7 12681 57 ; ; : cord-005453-4057qib7 12681 58 p=1.00 p=1.00 NNP cord-005453-4057qib7 12681 59 ) ) -RRB- cord-005453-4057qib7 12681 60 . . . cord-005453-4057qib7 12682 1 In in IN cord-005453-4057qib7 12682 2 univariate univariate JJ cord-005453-4057qib7 12682 3 analysis analysis NN cord-005453-4057qib7 12682 4 , , , cord-005453-4057qib7 12682 5 we -PRON- PRP cord-005453-4057qib7 12682 6 could could MD cord-005453-4057qib7 12682 7 not not RB cord-005453-4057qib7 12682 8 demonstrate demonstrate VB cord-005453-4057qib7 12682 9 the the DT cord-005453-4057qib7 12682 10 importance importance NN cord-005453-4057qib7 12682 11 of of IN cord-005453-4057qib7 12682 12 induction induction NN cord-005453-4057qib7 12682 13 therapy therapy NN cord-005453-4057qib7 12682 14 with with IN cord-005453-4057qib7 12682 15 novel novel JJ cord-005453-4057qib7 12682 16 agents agent NNS cord-005453-4057qib7 12682 17 the the DT cord-005453-4057qib7 12682 18 occurrence occurrence NN cord-005453-4057qib7 12682 19 of of IN cord-005453-4057qib7 12682 20 a a DT cord-005453-4057qib7 12682 21 post post JJ cord-005453-4057qib7 12682 22 - - JJ cord-005453-4057qib7 12682 23 ASCT asct JJ cord-005453-4057qib7 12682 24 CMV CMV NNP cord-005453-4057qib7 12682 25 reactivation reactivation NN cord-005453-4057qib7 12682 26 requiring require VBG cord-005453-4057qib7 12682 27 antiviral antiviral JJ cord-005453-4057qib7 12682 28 treatment treatment NN cord-005453-4057qib7 12682 29 . . . cord-005453-4057qib7 12683 1 However however RB cord-005453-4057qib7 12683 2 , , , cord-005453-4057qib7 12683 3 statistically statistically RB cord-005453-4057qib7 12683 4 significant significant JJ cord-005453-4057qib7 12683 5 association association NN cord-005453-4057qib7 12683 6 found find VBD cord-005453-4057qib7 12683 7 between between IN cord-005453-4057qib7 12683 8 the the DT cord-005453-4057qib7 12683 9 disease disease NN cord-005453-4057qib7 12683 10 < < XX cord-005453-4057qib7 12683 11 VGPR vgpr NN cord-005453-4057qib7 12683 12 status status NN cord-005453-4057qib7 12683 13 at at IN cord-005453-4057qib7 12683 14 ASCT ASCT NNP cord-005453-4057qib7 12683 15 and and CC cord-005453-4057qib7 12683 16 CMV CMV NNP cord-005453-4057qib7 12683 17 reactivation reactivation NN cord-005453-4057qib7 12683 18 ( ( -LRB- cord-005453-4057qib7 12683 19 61.1 61.1 CD cord-005453-4057qib7 12683 20 % % NN cord-005453-4057qib7 12683 21 vs. vs. NN cord-005453-4057qib7 12683 22 38.9 38.9 CD cord-005453-4057qib7 12683 23 % % NN cord-005453-4057qib7 12683 24 ; ; : cord-005453-4057qib7 12683 25 p=0.035 p=0.035 NNP cord-005453-4057qib7 12683 26 ) ) -RRB- cord-005453-4057qib7 12683 27 . . . cord-005453-4057qib7 12684 1 After after IN cord-005453-4057qib7 12684 2 a a DT cord-005453-4057qib7 12684 3 median median JJ cord-005453-4057qib7 12684 4 follow follow NN cord-005453-4057qib7 12684 5 - - HYPH cord-005453-4057qib7 12684 6 up up NN cord-005453-4057qib7 12684 7 14.3 14.3 CD cord-005453-4057qib7 12684 8 months month NNS cord-005453-4057qib7 12684 9 ( ( -LRB- cord-005453-4057qib7 12684 10 range range NN cord-005453-4057qib7 12684 11 ; ; : cord-005453-4057qib7 12684 12 1 1 CD cord-005453-4057qib7 12684 13 - - SYM cord-005453-4057qib7 12684 14 45.9 45.9 CD cord-005453-4057qib7 12684 15 months month NNS cord-005453-4057qib7 12684 16 ) ) -RRB- cord-005453-4057qib7 12684 17 , , , cord-005453-4057qib7 12684 18 there there EX cord-005453-4057qib7 12684 19 was be VBD cord-005453-4057qib7 12684 20 no no DT cord-005453-4057qib7 12684 21 significant significant JJ cord-005453-4057qib7 12684 22 impact impact NN cord-005453-4057qib7 12684 23 on on IN cord-005453-4057qib7 12684 24 PFS PFS NNP cord-005453-4057qib7 12684 25 , , , cord-005453-4057qib7 12684 26 however however WRB cord-005453-4057qib7 12684 27 there there EX cord-005453-4057qib7 12684 28 was be VBD cord-005453-4057qib7 12684 29 significant significant JJ cord-005453-4057qib7 12684 30 decrease decrease NN cord-005453-4057qib7 12684 31 in in IN cord-005453-4057qib7 12684 32 estimated estimate VBN cord-005453-4057qib7 12684 33 mean mean NN cord-005453-4057qib7 12684 34 OS OS NNP cord-005453-4057qib7 12684 35 who who WP cord-005453-4057qib7 12684 36 had have VBD cord-005453-4057qib7 12684 37 CMV CMV NNP cord-005453-4057qib7 12684 38 reactivation reactivation NN cord-005453-4057qib7 12684 39 when when WRB cord-005453-4057qib7 12684 40 compared compare VBN cord-005453-4057qib7 12684 41 to to IN cord-005453-4057qib7 12684 42 those those DT cord-005453-4057qib7 12684 43 without without IN cord-005453-4057qib7 12684 44 CMV CMV NNP cord-005453-4057qib7 12684 45 reactivation reactivation NN cord-005453-4057qib7 12684 46 ( ( -LRB- cord-005453-4057qib7 12684 47 34.1±4.5 34.1±4.5 CD cord-005453-4057qib7 12684 48 vs. vs. NN cord-005453-4057qib7 12684 49 41.9±1.3 41.9±1.3 CD cord-005453-4057qib7 12684 50 ; ; : cord-005453-4057qib7 12684 51 p=0.002 p=0.002 ADD cord-005453-4057qib7 12684 52 ) ) -RRB- cord-005453-4057qib7 12684 53 ( ( -LRB- cord-005453-4057qib7 12684 54 Figure-1 Figure-1 NNP cord-005453-4057qib7 12684 55 ) ) -RRB- cord-005453-4057qib7 12684 56 . . . cord-005453-4057qib7 12685 1 Conclusions conclusion NNS cord-005453-4057qib7 12685 2 : : : cord-005453-4057qib7 12686 1 CMV CMV NNP cord-005453-4057qib7 12686 2 establishes establish VBZ cord-005453-4057qib7 12686 3 lifelong lifelong JJ cord-005453-4057qib7 12686 4 latency latency NN cord-005453-4057qib7 12686 5 within within IN cord-005453-4057qib7 12686 6 host host NN cord-005453-4057qib7 12686 7 cells cell NNS cord-005453-4057qib7 12686 8 and and CC cord-005453-4057qib7 12686 9 in in IN cord-005453-4057qib7 12686 10 the the DT cord-005453-4057qib7 12686 11 setting setting NN cord-005453-4057qib7 12686 12 of of IN cord-005453-4057qib7 12686 13 impaired impaired JJ cord-005453-4057qib7 12686 14 cellular cellular JJ cord-005453-4057qib7 12686 15 immunity immunity NN cord-005453-4057qib7 12686 16 ; ; : cord-005453-4057qib7 12686 17 CMV CMV NNP cord-005453-4057qib7 12686 18 may may MD cord-005453-4057qib7 12686 19 reactivate reactivate VB cord-005453-4057qib7 12686 20 from from IN cord-005453-4057qib7 12686 21 latency latency NN cord-005453-4057qib7 12686 22 , , , cord-005453-4057qib7 12686 23 disseminate disseminate VB cord-005453-4057qib7 12686 24 , , , cord-005453-4057qib7 12686 25 and and CC cord-005453-4057qib7 12686 26 directly directly RB cord-005453-4057qib7 12686 27 cause cause VB cord-005453-4057qib7 12686 28 life life NN cord-005453-4057qib7 12686 29 - - HYPH cord-005453-4057qib7 12686 30 threatening threaten VBG cord-005453-4057qib7 12686 31 disease disease NN cord-005453-4057qib7 12686 32 . . . cord-005453-4057qib7 12687 1 Our -PRON- PRP$ cord-005453-4057qib7 12687 2 data data NN cord-005453-4057qib7 12687 3 suggests suggest VBZ cord-005453-4057qib7 12687 4 that that IN cord-005453-4057qib7 12687 5 MM MM NNP cord-005453-4057qib7 12687 6 patients patient NNS cord-005453-4057qib7 12687 7 treated treat VBN cord-005453-4057qib7 12687 8 with with IN cord-005453-4057qib7 12687 9 PI pi NN cord-005453-4057qib7 12687 10 - - HYPH cord-005453-4057qib7 12687 11 based base VBN cord-005453-4057qib7 12687 12 induction induction NN cord-005453-4057qib7 12687 13 regimens regimen NNS cord-005453-4057qib7 12687 14 and and CC cord-005453-4057qib7 12687 15 immunological immunological JJ cord-005453-4057qib7 12687 16 response response NN cord-005453-4057qib7 12687 17 < < XX cord-005453-4057qib7 12687 18 VGPR VGPR NNP cord-005453-4057qib7 12687 19 at at IN cord-005453-4057qib7 12687 20 time time NN cord-005453-4057qib7 12687 21 of of IN cord-005453-4057qib7 12687 22 ASCT ASCT NNP cord-005453-4057qib7 12687 23 seem seem VBP cord-005453-4057qib7 12687 24 to to TO cord-005453-4057qib7 12687 25 have have VB cord-005453-4057qib7 12687 26 higher high JJR cord-005453-4057qib7 12687 27 risk risk NN cord-005453-4057qib7 12687 28 of of IN cord-005453-4057qib7 12687 29 developing develop VBG cord-005453-4057qib7 12687 30 symptomatic symptomatic JJ cord-005453-4057qib7 12687 31 CMV CMV NNP cord-005453-4057qib7 12687 32 reactivation reactivation NN cord-005453-4057qib7 12687 33 . . . cord-005453-4057qib7 12688 1 However however RB cord-005453-4057qib7 12688 2 , , , cord-005453-4057qib7 12688 3 further further JJ cord-005453-4057qib7 12688 4 studies study NNS cord-005453-4057qib7 12688 5 on on IN cord-005453-4057qib7 12688 6 a a DT cord-005453-4057qib7 12688 7 large large JJ cord-005453-4057qib7 12688 8 number number NN cord-005453-4057qib7 12688 9 of of IN cord-005453-4057qib7 12688 10 patients patient NNS cord-005453-4057qib7 12688 11 are be VBP cord-005453-4057qib7 12688 12 warranted warrant VBN cord-005453-4057qib7 12688 13 to to TO cord-005453-4057qib7 12688 14 clarify clarify VB cord-005453-4057qib7 12688 15 these these DT cord-005453-4057qib7 12688 16 findings finding NNS cord-005453-4057qib7 12688 17 . . . cord-005453-4057qib7 12689 1 Clinical clinical JJ cord-005453-4057qib7 12689 2 Background background NN cord-005453-4057qib7 12689 3 : : : cord-005453-4057qib7 12689 4 High high JJ cord-005453-4057qib7 12689 5 - - HYPH cord-005453-4057qib7 12689 6 dose dose NN cord-005453-4057qib7 12689 7 therapy therapy NN cord-005453-4057qib7 12689 8 followed follow VBN cord-005453-4057qib7 12689 9 by by IN cord-005453-4057qib7 12689 10 autologous autologous JJ cord-005453-4057qib7 12689 11 stem stem NN cord-005453-4057qib7 12689 12 cell cell NN cord-005453-4057qib7 12689 13 transplantation transplantation NN cord-005453-4057qib7 12689 14 ( ( -LRB- cord-005453-4057qib7 12689 15 ASCT ASCT NNP cord-005453-4057qib7 12689 16 ) ) -RRB- cord-005453-4057qib7 12689 17 has have VBZ cord-005453-4057qib7 12689 18 been be VBN cord-005453-4057qib7 12689 19 shown show VBN cord-005453-4057qib7 12689 20 to to TO cord-005453-4057qib7 12689 21 prolong prolong VB cord-005453-4057qib7 12689 22 survival survival NN cord-005453-4057qib7 12689 23 in in IN cord-005453-4057qib7 12689 24 patients patient NNS cord-005453-4057qib7 12689 25 with with IN cord-005453-4057qib7 12689 26 multiple multiple JJ cord-005453-4057qib7 12689 27 myeloma myeloma NN cord-005453-4057qib7 12689 28 ( ( -LRB- cord-005453-4057qib7 12689 29 MM MM NNP cord-005453-4057qib7 12689 30 ) ) -RRB- cord-005453-4057qib7 12689 31 in in IN cord-005453-4057qib7 12689 32 randomized randomized JJ cord-005453-4057qib7 12689 33 trials trial NNS cord-005453-4057qib7 12689 34 . . . cord-005453-4057qib7 12690 1 However however RB cord-005453-4057qib7 12690 2 , , , cord-005453-4057qib7 12690 3 these these DT cord-005453-4057qib7 12690 4 trials trial NNS cord-005453-4057qib7 12690 5 only only RB cord-005453-4057qib7 12690 6 include include VBP cord-005453-4057qib7 12690 7 patients patient NNS cord-005453-4057qib7 12690 8 aged age VBN cord-005453-4057qib7 12690 9 < < XX cord-005453-4057qib7 12690 10 65 65 CD cord-005453-4057qib7 12690 11 years year NNS cord-005453-4057qib7 12690 12 . . . cord-005453-4057qib7 12691 1 Data datum NNS cord-005453-4057qib7 12691 2 regarding regard VBG cord-005453-4057qib7 12691 3 safety safety NN cord-005453-4057qib7 12691 4 and and CC cord-005453-4057qib7 12691 5 outcomes outcome NNS cord-005453-4057qib7 12691 6 in in IN cord-005453-4057qib7 12691 7 this this DT cord-005453-4057qib7 12691 8 patient patient JJ cord-005453-4057qib7 12691 9 population population NN cord-005453-4057qib7 12691 10 is be VBZ cord-005453-4057qib7 12691 11 lacking lack VBG cord-005453-4057qib7 12691 12 . . . cord-005453-4057qib7 12692 1 Methods method NNS cord-005453-4057qib7 12692 2 : : : cord-005453-4057qib7 12693 1 The the DT cord-005453-4057qib7 12693 2 aim aim NN cord-005453-4057qib7 12693 3 of of IN cord-005453-4057qib7 12693 4 this this DT cord-005453-4057qib7 12693 5 study study NN cord-005453-4057qib7 12693 6 was be VBD cord-005453-4057qib7 12693 7 to to TO cord-005453-4057qib7 12693 8 compare compare VB cord-005453-4057qib7 12693 9 safety safety NN cord-005453-4057qib7 12693 10 profile profile NN cord-005453-4057qib7 12693 11 and and CC cord-005453-4057qib7 12693 12 outcomes outcome NNS cord-005453-4057qib7 12693 13 in in IN cord-005453-4057qib7 12693 14 MM MM NNP cord-005453-4057qib7 12693 15 patients patient NNS cord-005453-4057qib7 12693 16 younger young JJR cord-005453-4057qib7 12693 17 and and CC cord-005453-4057qib7 12693 18 older old JJR cord-005453-4057qib7 12693 19 than than IN cord-005453-4057qib7 12693 20 65 65 CD cord-005453-4057qib7 12693 21 years year NNS cord-005453-4057qib7 12693 22 - - HYPH cord-005453-4057qib7 12693 23 old old JJ cord-005453-4057qib7 12693 24 who who WP cord-005453-4057qib7 12693 25 underwent undergo VBD cord-005453-4057qib7 12693 26 ASCT ASCT NNP cord-005453-4057qib7 12693 27 in in IN cord-005453-4057qib7 12693 28 our -PRON- PRP$ cord-005453-4057qib7 12693 29 Unit Unit NNP cord-005453-4057qib7 12693 30 from from IN cord-005453-4057qib7 12693 31 July July NNP cord-005453-4057qib7 12693 32 2014 2014 CD cord-005453-4057qib7 12693 33 to to IN cord-005453-4057qib7 12693 34 October October NNP cord-005453-4057qib7 12693 35 2018 2018 CD cord-005453-4057qib7 12693 36 . . . cord-005453-4057qib7 12694 1 Patient Patient NNP cord-005453-4057qib7 12694 2 's 's POS cord-005453-4057qib7 12694 3 demographics demographic NNS cord-005453-4057qib7 12694 4 , , , cord-005453-4057qib7 12694 5 clinical clinical JJ cord-005453-4057qib7 12694 6 characteristics characteristic NNS cord-005453-4057qib7 12694 7 , , , cord-005453-4057qib7 12694 8 transplant transplant NN cord-005453-4057qib7 12694 9 related relate VBN cord-005453-4057qib7 12694 10 variables variable NNS cord-005453-4057qib7 12694 11 and and CC cord-005453-4057qib7 12694 12 probability probability NN cord-005453-4057qib7 12694 13 of of IN cord-005453-4057qib7 12694 14 admission admission NN cord-005453-4057qib7 12694 15 to to IN cord-005453-4057qib7 12694 16 the the DT cord-005453-4057qib7 12694 17 Intensive Intensive NNP cord-005453-4057qib7 12694 18 Care Care NNP cord-005453-4057qib7 12694 19 Unit Unit NNP cord-005453-4057qib7 12694 20 ( ( -LRB- cord-005453-4057qib7 12694 21 ICU ICU NNP cord-005453-4057qib7 12694 22 ) ) -RRB- cord-005453-4057qib7 12694 23 were be VBD cord-005453-4057qib7 12694 24 analyzed analyze VBN cord-005453-4057qib7 12694 25 . . . cord-005453-4057qib7 12695 1 Patients patient NNS cord-005453-4057qib7 12695 2 aged age VBN cord-005453-4057qib7 12695 3 < < XX cord-005453-4057qib7 12695 4 65 65 CD cord-005453-4057qib7 12695 5 and and CC cord-005453-4057qib7 12695 6 ≥65 ≥65 NNP cord-005453-4057qib7 12695 7 years year NNS cord-005453-4057qib7 12695 8 - - HYPH cord-005453-4057qib7 12695 9 old old JJ cord-005453-4057qib7 12695 10 would would MD cord-005453-4057qib7 12695 11 be be VB cord-005453-4057qib7 12695 12 called call VBN cord-005453-4057qib7 12695 13 M1 M1 NNP cord-005453-4057qib7 12695 14 and and CC cord-005453-4057qib7 12695 15 M2 M2 NNP cord-005453-4057qib7 12695 16 , , , cord-005453-4057qib7 12695 17 respectively respectively RB cord-005453-4057qib7 12695 18 , , , cord-005453-4057qib7 12695 19 from from IN cord-005453-4057qib7 12695 20 now now RB cord-005453-4057qib7 12695 21 on on RB cord-005453-4057qib7 12695 22 . . . cord-005453-4057qib7 12696 1 Sorror Sorror NNP cord-005453-4057qib7 12696 2 index index NN cord-005453-4057qib7 12696 3 was be VBD cord-005453-4057qib7 12696 4 used use VBN cord-005453-4057qib7 12696 5 to to TO cord-005453-4057qib7 12696 6 estimate estimate VB cord-005453-4057qib7 12696 7 risk risk NN cord-005453-4057qib7 12696 8 of of IN cord-005453-4057qib7 12696 9 mortality mortality NN cord-005453-4057qib7 12696 10 in in IN cord-005453-4057qib7 12696 11 the the DT cord-005453-4057qib7 12696 12 two two CD cord-005453-4057qib7 12696 13 cohorts cohort NNS cord-005453-4057qib7 12696 14 . . . cord-005453-4057qib7 12697 1 Results result NNS cord-005453-4057qib7 12697 2 : : : cord-005453-4057qib7 12698 1 A a DT cord-005453-4057qib7 12698 2 hundred hundred CD cord-005453-4057qib7 12698 3 and and CC cord-005453-4057qib7 12698 4 eleven eleven CD cord-005453-4057qib7 12698 5 patients patient NNS cord-005453-4057qib7 12698 6 with with IN cord-005453-4057qib7 12698 7 MM MM NNP cord-005453-4057qib7 12698 8 underwent undergo VBD cord-005453-4057qib7 12698 9 ASCT ASCT NNP cord-005453-4057qib7 12698 10 in in IN cord-005453-4057qib7 12698 11 the the DT cord-005453-4057qib7 12698 12 study study NN cord-005453-4057qib7 12698 13 period period NN cord-005453-4057qib7 12698 14 . . . cord-005453-4057qib7 12699 1 Median median JJ cord-005453-4057qib7 12699 2 age age NN cord-005453-4057qib7 12699 3 was be VBD cord-005453-4057qib7 12699 4 60.9 60.9 CD cord-005453-4057qib7 12699 5 years year NNS cord-005453-4057qib7 12699 6 - - HYPH cord-005453-4057qib7 12699 7 old old JJ cord-005453-4057qib7 12699 8 ( ( -LRB- cord-005453-4057qib7 12699 9 range range NN cord-005453-4057qib7 12699 10 35 35 CD cord-005453-4057qib7 12699 11 - - SYM cord-005453-4057qib7 12699 12 73 73 CD cord-005453-4057qib7 12699 13 ) ) -RRB- cord-005453-4057qib7 12699 14 and and CC cord-005453-4057qib7 12699 15 53.2 53.2 CD cord-005453-4057qib7 12699 16 % % NN cord-005453-4057qib7 12699 17 were be VBD cord-005453-4057qib7 12699 18 male male JJ cord-005453-4057qib7 12699 19 . . . cord-005453-4057qib7 12700 1 Thirtythree Thirtythree NNP cord-005453-4057qib7 12700 2 ( ( -LRB- cord-005453-4057qib7 12700 3 28,8 28,8 CD cord-005453-4057qib7 12700 4 % % NN cord-005453-4057qib7 12700 5 ) ) -RRB- cord-005453-4057qib7 12700 6 patients patient NNS cord-005453-4057qib7 12700 7 were be VBD cord-005453-4057qib7 12700 8 ≥ ≥ CD cord-005453-4057qib7 12700 9 65 65 CD cord-005453-4057qib7 12700 10 years year NNS cord-005453-4057qib7 12700 11 . . . cord-005453-4057qib7 12701 1 The the DT cord-005453-4057qib7 12701 2 probability probability NN cord-005453-4057qib7 12701 3 of of IN cord-005453-4057qib7 12701 4 having have VBG cord-005453-4057qib7 12701 5 a a DT cord-005453-4057qib7 12701 6 high high JJ cord-005453-4057qib7 12701 7 risk risk NN cord-005453-4057qib7 12701 8 comorbidity comorbidity NN cord-005453-4057qib7 12701 9 index index NN cord-005453-4057qib7 12701 10 was be VBD cord-005453-4057qib7 12701 11 similar similar JJ cord-005453-4057qib7 12701 12 in in IN cord-005453-4057qib7 12701 13 both both DT cord-005453-4057qib7 12701 14 groups group NNS cord-005453-4057qib7 12701 15 ( ( -LRB- cord-005453-4057qib7 12701 16 M1 M1 NNP cord-005453-4057qib7 12701 17 11,7 11,7 CD cord-005453-4057qib7 12702 1 vsM2 vsm2 RB cord-005453-4057qib7 12702 2 12,1 12,1 CD cord-005453-4057qib7 12702 3 % % NN cord-005453-4057qib7 12702 4 ) ) -RRB- cord-005453-4057qib7 12702 5 . . . cord-005453-4057qib7 12703 1 The the DT cord-005453-4057qib7 12703 2 median median JJ cord-005453-4057qib7 12703 3 cells cell NNS cord-005453-4057qib7 12703 4 obtained obtain VBN cord-005453-4057qib7 12703 5 in in IN cord-005453-4057qib7 12703 6 the the DT cord-005453-4057qib7 12703 7 apheresis apheresis NN cord-005453-4057qib7 12703 8 procedure procedure NN cord-005453-4057qib7 12703 9 was be VBD cord-005453-4057qib7 12703 10 5.35 5.35 CD cord-005453-4057qib7 12703 11 x10 x10 NN cord-005453-4057qib7 12703 12 6 6 CD cord-005453-4057qib7 12703 13 ( ( -LRB- cord-005453-4057qib7 12703 14 1,70 1,70 NNP cord-005453-4057qib7 12703 15 - - HYPH cord-005453-4057qib7 12703 16 15.92 15.92 CD cord-005453-4057qib7 12703 17 ) ) -RRB- cord-005453-4057qib7 12703 18 in in IN cord-005453-4057qib7 12703 19 M1 M1 NNP cord-005453-4057qib7 12703 20 compared compare VBN cord-005453-4057qib7 12703 21 to to IN cord-005453-4057qib7 12703 22 3.77 3.77 CD cord-005453-4057qib7 12703 23 x10 x10 NN cord-005453-4057qib7 12703 24 6 6 CD cord-005453-4057qib7 12703 25 ( ( -LRB- cord-005453-4057qib7 12703 26 1.96 1.96 CD cord-005453-4057qib7 12703 27 - - SYM cord-005453-4057qib7 12703 28 10 10 CD cord-005453-4057qib7 12703 29 - - SYM cord-005453-4057qib7 12703 30 48 48 CD cord-005453-4057qib7 12703 31 ) ) -RRB- cord-005453-4057qib7 12703 32 in in IN cord-005453-4057qib7 12703 33 M2 M2 NNP cord-005453-4057qib7 12703 34 . . . cord-005453-4057qib7 12704 1 There there EX cord-005453-4057qib7 12704 2 were be VBD cord-005453-4057qib7 12704 3 no no DT cord-005453-4057qib7 12704 4 differences difference NNS cord-005453-4057qib7 12704 5 in in IN cord-005453-4057qib7 12704 6 median median JJ cord-005453-4057qib7 12704 7 admission admission NN cord-005453-4057qib7 12704 8 lenght lenght NN cord-005453-4057qib7 12704 9 between between IN cord-005453-4057qib7 12704 10 the the DT cord-005453-4057qib7 12704 11 2 2 CD cord-005453-4057qib7 12704 12 cohorts cohort NNS cord-005453-4057qib7 12704 13 ( ( -LRB- cord-005453-4057qib7 12704 14 M1:19 m1:19 $ cord-005453-4057qib7 12704 15 days day NNS cord-005453-4057qib7 12704 16 vs vs IN cord-005453-4057qib7 12704 17 M2 M2 NNP cord-005453-4057qib7 12704 18 : : : cord-005453-4057qib7 12704 19 20 20 CD cord-005453-4057qib7 12704 20 days day NNS cord-005453-4057qib7 12704 21 ) ) -RRB- cord-005453-4057qib7 12704 22 . . . cord-005453-4057qib7 12705 1 Median median JJ cord-005453-4057qib7 12705 2 days day NNS cord-005453-4057qib7 12705 3 for for IN cord-005453-4057qib7 12705 4 neutrophil neutrophil NN cord-005453-4057qib7 12705 5 recovery recovery NN cord-005453-4057qib7 12705 6 above above IN cord-005453-4057qib7 12705 7 1000 1000 CD cord-005453-4057qib7 12705 8 was be VBD cord-005453-4057qib7 12705 9 12 12 CD cord-005453-4057qib7 12705 10 days day NNS cord-005453-4057qib7 12705 11 in in IN cord-005453-4057qib7 12705 12 both both DT cord-005453-4057qib7 12705 13 groups group NNS cord-005453-4057qib7 12705 14 with with IN cord-005453-4057qib7 12705 15 a a DT cord-005453-4057qib7 12705 16 wider wide JJR cord-005453-4057qib7 12705 17 range range NN cord-005453-4057qib7 12705 18 in in IN cord-005453-4057qib7 12705 19 M1 M1 NNP cord-005453-4057qib7 12705 20 ( ( -LRB- cord-005453-4057qib7 12705 21 11 11 CD cord-005453-4057qib7 12705 22 - - SYM cord-005453-4057qib7 12705 23 23 23 CD cord-005453-4057qib7 12705 24 ) ) -RRB- cord-005453-4057qib7 12705 25 compared compare VBN cord-005453-4057qib7 12705 26 to to IN cord-005453-4057qib7 12705 27 M2 M2 NNP cord-005453-4057qib7 12705 28 ( ( -LRB- cord-005453-4057qib7 12705 29 11 11 CD cord-005453-4057qib7 12705 30 - - SYM cord-005453-4057qib7 12705 31 15 15 CD cord-005453-4057qib7 12705 32 ) ) -RRB- cord-005453-4057qib7 12705 33 . . . cord-005453-4057qib7 12706 1 No no DT cord-005453-4057qib7 12706 2 differences difference NNS cord-005453-4057qib7 12706 3 were be VBD cord-005453-4057qib7 12706 4 found find VBN cord-005453-4057qib7 12706 5 in in IN cord-005453-4057qib7 12706 6 platelet platelet NN cord-005453-4057qib7 12706 7 recovery recovery NN cord-005453-4057qib7 12706 8 above above IN cord-005453-4057qib7 12706 9 100.000 100.000 CD cord-005453-4057qib7 12706 10 ( ( -LRB- cord-005453-4057qib7 12706 11 M1 M1 NNP cord-005453-4057qib7 12706 12 20 20 CD cord-005453-4057qib7 12706 13 days day NNS cord-005453-4057qib7 12706 14 vs vs IN cord-005453-4057qib7 12706 15 M2 M2 NNP cord-005453-4057qib7 12706 16 21 21 CD cord-005453-4057qib7 12706 17 days day NNS cord-005453-4057qib7 12706 18 ) ) -RRB- cord-005453-4057qib7 12706 19 . . . cord-005453-4057qib7 12707 1 Median median JJ cord-005453-4057qib7 12707 2 packed pack VBD cord-005453-4057qib7 12707 3 red red JJ cord-005453-4057qib7 12707 4 blood blood NN cord-005453-4057qib7 12707 5 cells cell NNS cord-005453-4057qib7 12707 6 and and CC cord-005453-4057qib7 12707 7 platelets platelet NNS cord-005453-4057qib7 12707 8 transfusions transfusion NNS cord-005453-4057qib7 12707 9 were be VBD cord-005453-4057qib7 12707 10 1 1 CD cord-005453-4057qib7 12707 11 ( ( -LRB- cord-005453-4057qib7 12707 12 0 0 CD cord-005453-4057qib7 12707 13 - - SYM cord-005453-4057qib7 12707 14 6 6 CD cord-005453-4057qib7 12707 15 ) ) -RRB- cord-005453-4057qib7 12707 16 and and CC cord-005453-4057qib7 12707 17 3 3 CD cord-005453-4057qib7 12707 18 ( ( -LRB- cord-005453-4057qib7 12707 19 0 0 CD cord-005453-4057qib7 12707 20 - - SYM cord-005453-4057qib7 12707 21 16 16 CD cord-005453-4057qib7 12707 22 ) ) -RRB- cord-005453-4057qib7 12707 23 , , , cord-005453-4057qib7 12707 24 respectively respectively RB cord-005453-4057qib7 12707 25 , , , cord-005453-4057qib7 12707 26 in in IN cord-005453-4057qib7 12707 27 M1 M1 NNP cord-005453-4057qib7 12707 28 . . . cord-005453-4057qib7 12708 1 In in IN cord-005453-4057qib7 12708 2 M2 M2 NNP cord-005453-4057qib7 12708 3 cohort cohort NN cord-005453-4057qib7 12708 4 , , , cord-005453-4057qib7 12708 5 they -PRON- PRP cord-005453-4057qib7 12708 6 were be VBD cord-005453-4057qib7 12708 7 2 2 CD cord-005453-4057qib7 12708 8 ( ( -LRB- cord-005453-4057qib7 12708 9 0 0 CD cord-005453-4057qib7 12708 10 - - SYM cord-005453-4057qib7 12708 11 5 5 CD cord-005453-4057qib7 12708 12 ) ) -RRB- cord-005453-4057qib7 12708 13 and and CC cord-005453-4057qib7 12708 14 4 4 LS cord-005453-4057qib7 12708 15 ( ( -LRB- cord-005453-4057qib7 12708 16 0 0 CD cord-005453-4057qib7 12708 17 - - SYM cord-005453-4057qib7 12708 18 14 14 CD cord-005453-4057qib7 12708 19 ) ) -RRB- cord-005453-4057qib7 12708 20 , , , cord-005453-4057qib7 12708 21 respectively respectively RB cord-005453-4057qib7 12708 22 . . . cord-005453-4057qib7 12709 1 The the DT cord-005453-4057qib7 12709 2 incidence incidence NN cord-005453-4057qib7 12709 3 of of IN cord-005453-4057qib7 12709 4 grade grade NN cord-005453-4057qib7 12709 5 3 3 CD cord-005453-4057qib7 12709 6 - - SYM cord-005453-4057qib7 12709 7 4 4 CD cord-005453-4057qib7 12709 8 mucositis mucositis NN cord-005453-4057qib7 12709 9 in in IN cord-005453-4057qib7 12709 10 M1 M1 NNP cord-005453-4057qib7 12709 11 and and CC cord-005453-4057qib7 12709 12 M2 M2 NNP cord-005453-4057qib7 12709 13 was be VBD cord-005453-4057qib7 12709 14 50.6 50.6 CD cord-005453-4057qib7 12709 15 % % NN cord-005453-4057qib7 12709 16 and and CC cord-005453-4057qib7 12709 17 44.1 44.1 CD cord-005453-4057qib7 12709 18 % % NN cord-005453-4057qib7 12709 19 , , , cord-005453-4057qib7 12709 20 respectively respectively RB cord-005453-4057qib7 12709 21 . . . cord-005453-4057qib7 12710 1 There there EX cord-005453-4057qib7 12710 2 were be VBD cord-005453-4057qib7 12710 3 no no DT cord-005453-4057qib7 12710 4 statistically statistically RB cord-005453-4057qib7 12710 5 significant significant JJ cord-005453-4057qib7 12710 6 differences difference NNS cord-005453-4057qib7 12710 7 in in IN cord-005453-4057qib7 12710 8 terms term NNS cord-005453-4057qib7 12710 9 of of IN cord-005453-4057qib7 12710 10 using use VBG cord-005453-4057qib7 12710 11 morphine morphine NN cord-005453-4057qib7 12710 12 for for IN cord-005453-4057qib7 12710 13 pain pain NN cord-005453-4057qib7 12710 14 control control NN cord-005453-4057qib7 12710 15 between between IN cord-005453-4057qib7 12710 16 the the DT cord-005453-4057qib7 12710 17 two two CD cord-005453-4057qib7 12710 18 cohorts cohort NNS cord-005453-4057qib7 12710 19 ( ( -LRB- cord-005453-4057qib7 12710 20 M1 M1 NNP cord-005453-4057qib7 12710 21 , , , cord-005453-4057qib7 12710 22 63,4 63,4 CD cord-005453-4057qib7 12710 23 % % NN cord-005453-4057qib7 12710 24 vsM2 vsm2 NN cord-005453-4057qib7 12710 25 , , , cord-005453-4057qib7 12710 26 58,8 58,8 CD cord-005453-4057qib7 12710 27 % % NN cord-005453-4057qib7 12710 28 ) ) -RRB- cord-005453-4057qib7 12710 29 . . . cord-005453-4057qib7 12711 1 None none NN cord-005453-4057qib7 12711 2 patient patient NN cord-005453-4057qib7 12711 3 requiered requiere VBD cord-005453-4057qib7 12711 4 total total JJ cord-005453-4057qib7 12711 5 parenteral parenteral JJ cord-005453-4057qib7 12711 6 nutrition nutrition NN cord-005453-4057qib7 12711 7 ( ( -LRB- cord-005453-4057qib7 12711 8 TPN TPN NNP cord-005453-4057qib7 12711 9 ) ) -RRB- cord-005453-4057qib7 12711 10 in in IN cord-005453-4057qib7 12711 11 group group NN cord-005453-4057qib7 12711 12 M2 M2 NNP cord-005453-4057qib7 12711 13 and and CC cord-005453-4057qib7 12711 14 only only RB cord-005453-4057qib7 12711 15 one one CD cord-005453-4057qib7 12711 16 in in IN cord-005453-4057qib7 12711 17 group group NN cord-005453-4057qib7 12711 18 M1 M1 NNP cord-005453-4057qib7 12711 19 . . . cord-005453-4057qib7 12712 1 The the DT cord-005453-4057qib7 12712 2 incidence incidence NN cord-005453-4057qib7 12712 3 of of IN cord-005453-4057qib7 12712 4 ICU ICU NNP cord-005453-4057qib7 12712 5 admission admission NN cord-005453-4057qib7 12712 6 was be VBD cord-005453-4057qib7 12712 7 1.5 1.5 CD cord-005453-4057qib7 12712 8 times time NNS cord-005453-4057qib7 12712 9 higher high JJR cord-005453-4057qib7 12712 10 in in IN cord-005453-4057qib7 12712 11 patients patient NNS cord-005453-4057qib7 12712 12 aged age VBN cord-005453-4057qib7 12712 13 ≥65 ≥65 NNP cord-005453-4057qib7 12712 14 than than IN cord-005453-4057qib7 12712 15 in in IN cord-005453-4057qib7 12712 16 patients patient NNS cord-005453-4057qib7 12712 17 < < XX cord-005453-4057qib7 12712 18 65 65 CD cord-005453-4057qib7 12712 19 years year NNS cord-005453-4057qib7 12712 20 - - HYPH cord-005453-4057qib7 12712 21 old old JJ cord-005453-4057qib7 12712 22 6,1 6,1 CD cord-005453-4057qib7 12712 23 % % NN cord-005453-4057qib7 12712 24 vs3,9 vs3,9 NNP cord-005453-4057qib7 12712 25 % % NN cord-005453-4057qib7 12712 26 ) ) -RRB- cord-005453-4057qib7 12712 27 , , , cord-005453-4057qib7 12712 28 but but CC cord-005453-4057qib7 12712 29 differences difference NNS cord-005453-4057qib7 12712 30 were be VBD cord-005453-4057qib7 12712 31 not not RB cord-005453-4057qib7 12712 32 statistically statistically RB cord-005453-4057qib7 12712 33 significant significant JJ cord-005453-4057qib7 12712 34 ( ( -LRB- cord-005453-4057qib7 12712 35 p p NN cord-005453-4057qib7 12712 36 = = SYM cord-005453-4057qib7 12712 37 0.52 0.52 CD cord-005453-4057qib7 12712 38 ) ) -RRB- cord-005453-4057qib7 12712 39 . . . cord-005453-4057qib7 12713 1 There there EX cord-005453-4057qib7 12713 2 were be VBD cord-005453-4057qib7 12713 3 no no DT cord-005453-4057qib7 12713 4 deaths death NNS cord-005453-4057qib7 12713 5 during during IN cord-005453-4057qib7 12713 6 the the DT cord-005453-4057qib7 12713 7 transplant transplant NN cord-005453-4057qib7 12713 8 procedure procedure NN cord-005453-4057qib7 12713 9 in in IN cord-005453-4057qib7 12713 10 any any DT cord-005453-4057qib7 12713 11 of of IN cord-005453-4057qib7 12713 12 the the DT cord-005453-4057qib7 12713 13 2 2 CD cord-005453-4057qib7 12713 14 cohorts cohort NNS cord-005453-4057qib7 12713 15 Conclusions conclusion NNS cord-005453-4057qib7 12713 16 : : : cord-005453-4057qib7 12713 17 1 1 LS cord-005453-4057qib7 12713 18 ) ) -RRB- cord-005453-4057qib7 12714 1 In in IN cord-005453-4057qib7 12714 2 our -PRON- PRP$ cord-005453-4057qib7 12714 3 series series NN cord-005453-4057qib7 12714 4 , , , cord-005453-4057qib7 12714 5 high high JJ cord-005453-4057qib7 12714 6 - - HYPH cord-005453-4057qib7 12714 7 dose dose NN cord-005453-4057qib7 12714 8 therapy therapy NN cord-005453-4057qib7 12714 9 followed follow VBN cord-005453-4057qib7 12714 10 by by IN cord-005453-4057qib7 12714 11 autologous autologous JJ cord-005453-4057qib7 12714 12 hematopoietic hematopoietic JJ cord-005453-4057qib7 12714 13 cell cell NN cord-005453-4057qib7 12714 14 transplantation transplantation NN cord-005453-4057qib7 12714 15 in in IN cord-005453-4057qib7 12714 16 MM MM NNP cord-005453-4057qib7 12714 17 patients patient NNS cord-005453-4057qib7 12714 18 aged age VBN cord-005453-4057qib7 12714 19 ≥65 ≥65 PRP cord-005453-4057qib7 12714 20 was be VBD cord-005453-4057qib7 12714 21 feasible feasible JJ cord-005453-4057qib7 12714 22 . . . cord-005453-4057qib7 12715 1 2 2 LS cord-005453-4057qib7 12715 2 ) ) -RRB- cord-005453-4057qib7 12716 1 Transplant transplant NN cord-005453-4057qib7 12716 2 procedure procedure NN cord-005453-4057qib7 12716 3 in in IN cord-005453-4057qib7 12716 4 older old JJR cord-005453-4057qib7 12716 5 patients patient NNS cord-005453-4057qib7 12716 6 was be VBD cord-005453-4057qib7 12716 7 as as RB cord-005453-4057qib7 12716 8 safe safe JJ cord-005453-4057qib7 12716 9 as as IN cord-005453-4057qib7 12716 10 in in IN cord-005453-4057qib7 12716 11 patients patient NNS cord-005453-4057qib7 12716 12 < < XX cord-005453-4057qib7 12716 13 65 65 CD cord-005453-4057qib7 12716 14 years year NNS cord-005453-4057qib7 12716 15 - - HYPH cord-005453-4057qib7 12716 16 old old JJ cord-005453-4057qib7 12716 17 . . . cord-005453-4057qib7 12717 1 3 3 LS cord-005453-4057qib7 12717 2 ) ) -RRB- cord-005453-4057qib7 12718 1 No no DT cord-005453-4057qib7 12718 2 differences difference NNS cord-005453-4057qib7 12718 3 were be VBD cord-005453-4057qib7 12718 4 found find VBN cord-005453-4057qib7 12718 5 in in IN cord-005453-4057qib7 12718 6 terms term NNS cord-005453-4057qib7 12718 7 of of IN cord-005453-4057qib7 12718 8 graft graft NN cord-005453-4057qib7 12718 9 , , , cord-005453-4057qib7 12718 10 transfusion transfusion NN cord-005453-4057qib7 12718 11 support support NN cord-005453-4057qib7 12718 12 , , , cord-005453-4057qib7 12718 13 transplant transplant NN cord-005453-4057qib7 12718 14 related relate VBN cord-005453-4057qib7 12718 15 complications complication NNS cord-005453-4057qib7 12718 16 and and CC cord-005453-4057qib7 12718 17 length length NN cord-005453-4057qib7 12718 18 of of IN cord-005453-4057qib7 12718 19 admission admission NN cord-005453-4057qib7 12718 20 . . . cord-005453-4057qib7 12719 1 4 4 LS cord-005453-4057qib7 12719 2 ) ) -RRB- cord-005453-4057qib7 12720 1 Age age NN cord-005453-4057qib7 12720 2 should should MD cord-005453-4057qib7 12720 3 not not RB cord-005453-4057qib7 12720 4 be be VB cord-005453-4057qib7 12720 5 a a DT cord-005453-4057qib7 12720 6 limiting limit VBG cord-005453-4057qib7 12720 7 factor factor NN cord-005453-4057qib7 12720 8 in in IN cord-005453-4057qib7 12720 9 considering consider VBG cord-005453-4057qib7 12720 10 the the DT cord-005453-4057qib7 12720 11 modality modality NN cord-005453-4057qib7 12720 12 of of IN cord-005453-4057qib7 12720 13 ASCT ASCT NNP cord-005453-4057qib7 12720 14 in in IN cord-005453-4057qib7 12720 15 this this DT cord-005453-4057qib7 12720 16 patient patient JJ cord-005453-4057qib7 12720 17 population population NN cord-005453-4057qib7 12720 18 Disclosure disclosure NN cord-005453-4057qib7 12720 19 : : : cord-005453-4057qib7 12720 20 Nothing nothing NN cord-005453-4057qib7 12720 21 to to TO cord-005453-4057qib7 12720 22 declare declare VB cord-005453-4057qib7 12720 23 The the DT cord-005453-4057qib7 12720 24 correlation correlation NN cord-005453-4057qib7 12720 25 between between IN cord-005453-4057qib7 12720 26 the the DT cord-005453-4057qib7 12720 27 kinetics kinetic NNS cord-005453-4057qib7 12720 28 of of IN cord-005453-4057qib7 12720 29 peripheral peripheral JJ cord-005453-4057qib7 12720 30 blood blood NN cord-005453-4057qib7 12720 31 counts count NNS cord-005453-4057qib7 12720 32 and and CC cord-005453-4057qib7 12720 33 the the DT cord-005453-4057qib7 12720 34 response response NN cord-005453-4057qib7 12720 35 to to IN cord-005453-4057qib7 12720 36 treatment treatment NN cord-005453-4057qib7 12720 37 after after IN cord-005453-4057qib7 12720 38 high high JJ cord-005453-4057qib7 12720 39 - - HYPH cord-005453-4057qib7 12720 40 dose dose NN cord-005453-4057qib7 12720 41 melphalan melphalan NN cord-005453-4057qib7 12720 42 with with IN cord-005453-4057qib7 12720 43 stem stem NN cord-005453-4057qib7 12720 44 cell cell NN cord-005453-4057qib7 12720 45 support support NN cord-005453-4057qib7 12720 46 in in IN cord-005453-4057qib7 12720 47 multiple multiple JJ cord-005453-4057qib7 12720 48 myeloma myeloma NN cord-005453-4057qib7 12720 49 patients patient NNS cord-005453-4057qib7 12721 1 Background background NN cord-005453-4057qib7 12721 2 : : : cord-005453-4057qib7 12722 1 The the DT cord-005453-4057qib7 12722 2 long long JJ cord-005453-4057qib7 12722 3 - - HYPH cord-005453-4057qib7 12722 4 term term NN cord-005453-4057qib7 12722 5 survival survival NN cord-005453-4057qib7 12722 6 of of IN cord-005453-4057qib7 12722 7 MM MM NNP cord-005453-4057qib7 12722 8 patients patient NNS cord-005453-4057qib7 12722 9 has have VBZ cord-005453-4057qib7 12722 10 dramatically dramatically RB cord-005453-4057qib7 12722 11 increased increase VBN cord-005453-4057qib7 12722 12 in in IN cord-005453-4057qib7 12722 13 the the DT cord-005453-4057qib7 12722 14 last last JJ cord-005453-4057qib7 12722 15 20 20 CD cord-005453-4057qib7 12722 16 years year NNS cord-005453-4057qib7 12722 17 , , , cord-005453-4057qib7 12722 18 particularly particularly RB cord-005453-4057qib7 12722 19 for for IN cord-005453-4057qib7 12722 20 younger young JJR cord-005453-4057qib7 12722 21 patients patient NNS cord-005453-4057qib7 12722 22 . . . cord-005453-4057qib7 12723 1 This this DT cord-005453-4057qib7 12723 2 is be VBZ cord-005453-4057qib7 12723 3 attributable attributable JJ cord-005453-4057qib7 12723 4 in in IN cord-005453-4057qib7 12723 5 part part NN cord-005453-4057qib7 12723 6 to to IN cord-005453-4057qib7 12723 7 the the DT cord-005453-4057qib7 12723 8 introduction introduction NN cord-005453-4057qib7 12723 9 and and CC cord-005453-4057qib7 12723 10 development development NN cord-005453-4057qib7 12723 11 of of IN cord-005453-4057qib7 12723 12 high high JJ cord-005453-4057qib7 12723 13 dose dose NN cord-005453-4057qib7 12723 14 chemotherapy chemotherapy NN cord-005453-4057qib7 12723 15 with with IN cord-005453-4057qib7 12723 16 melphalan melphalan NNP cord-005453-4057qib7 12723 17 with with IN cord-005453-4057qib7 12723 18 stem stem NN cord-005453-4057qib7 12723 19 cell cell NN cord-005453-4057qib7 12723 20 support support NN cord-005453-4057qib7 12723 21 ( ( -LRB- cord-005453-4057qib7 12723 22 HDM HDM NNP cord-005453-4057qib7 12723 23 - - HYPH cord-005453-4057qib7 12723 24 ASCT ASCT NNP cord-005453-4057qib7 12723 25 ) ) -RRB- cord-005453-4057qib7 12723 26 . . . cord-005453-4057qib7 12724 1 Currently currently RB cord-005453-4057qib7 12724 2 , , , cord-005453-4057qib7 12724 3 frontline frontline JJ cord-005453-4057qib7 12724 4 ASCT ASCT NNP cord-005453-4057qib7 12724 5 is be VBZ cord-005453-4057qib7 12724 6 still still RB cord-005453-4057qib7 12724 7 considered consider VBN cord-005453-4057qib7 12724 8 the the DT cord-005453-4057qib7 12724 9 standard standard NN cord-005453-4057qib7 12724 10 of of IN cord-005453-4057qib7 12724 11 care care NN cord-005453-4057qib7 12724 12 for for IN cord-005453-4057qib7 12724 13 all all DT cord-005453-4057qib7 12724 14 eligible eligible JJ cord-005453-4057qib7 12724 15 patients patient NNS cord-005453-4057qib7 12724 16 . . . cord-005453-4057qib7 12725 1 Many many JJ cord-005453-4057qib7 12725 2 prognostic prognostic JJ cord-005453-4057qib7 12725 3 factors factor NNS cord-005453-4057qib7 12725 4 pre pre VBP cord-005453-4057qib7 12725 5 and and CC cord-005453-4057qib7 12725 6 post post JJ cord-005453-4057qib7 12725 7 transplantation transplantation NN cord-005453-4057qib7 12725 8 have have VBP cord-005453-4057qib7 12725 9 been be VBN cord-005453-4057qib7 12725 10 identified identify VBN cord-005453-4057qib7 12725 11 , , , cord-005453-4057qib7 12725 12 e.g. e.g. RB cord-005453-4057qib7 12725 13 : : : cord-005453-4057qib7 12725 14 age age NN cord-005453-4057qib7 12725 15 , , , cord-005453-4057qib7 12725 16 comorbidities comorbiditie NNS cord-005453-4057qib7 12725 17 , , , cord-005453-4057qib7 12725 18 cytogenitcs cytogenitc NNS cord-005453-4057qib7 12725 19 , , , cord-005453-4057qib7 12725 20 response response NN cord-005453-4057qib7 12725 21 to to IN cord-005453-4057qib7 12725 22 treatment treatment NN cord-005453-4057qib7 12725 23 and and CC cord-005453-4057qib7 12725 24 disease disease NN cord-005453-4057qib7 12725 25 status status NN cord-005453-4057qib7 12725 26 prior prior RB cord-005453-4057qib7 12725 27 to to IN cord-005453-4057qib7 12725 28 and and CC cord-005453-4057qib7 12725 29 post post VB cord-005453-4057qib7 12725 30 transplantation transplantation NN cord-005453-4057qib7 12725 31 . . . cord-005453-4057qib7 12726 1 To to IN cord-005453-4057qib7 12726 2 our -PRON- PRP$ cord-005453-4057qib7 12726 3 knowledge knowledge NN cord-005453-4057qib7 12726 4 there there EX cord-005453-4057qib7 12726 5 is be VBZ cord-005453-4057qib7 12726 6 no no DT cord-005453-4057qib7 12726 7 data data NN cord-005453-4057qib7 12726 8 correlating correlate VBG cord-005453-4057qib7 12726 9 between between IN cord-005453-4057qib7 12726 10 kinetics kinetic NNS cord-005453-4057qib7 12726 11 of of IN cord-005453-4057qib7 12726 12 counts count NNS cord-005453-4057qib7 12726 13 response response NN cord-005453-4057qib7 12726 14 to to IN cord-005453-4057qib7 12726 15 melphalan melphalan NNP cord-005453-4057qib7 12726 16 and and CC cord-005453-4057qib7 12726 17 prognosis prognosis NN cord-005453-4057qib7 12726 18 . . . cord-005453-4057qib7 12727 1 Our -PRON- PRP$ cord-005453-4057qib7 12727 2 aim aim NN cord-005453-4057qib7 12727 3 was be VBD cord-005453-4057qib7 12727 4 to to TO cord-005453-4057qib7 12727 5 assess assess VB cord-005453-4057qib7 12727 6 the the DT cord-005453-4057qib7 12727 7 prognostic prognostic JJ cord-005453-4057qib7 12727 8 significance significance NN cord-005453-4057qib7 12727 9 of of IN cord-005453-4057qib7 12727 10 the the DT cord-005453-4057qib7 12727 11 neutrophil neutrophil NN cord-005453-4057qib7 12727 12 and and CC cord-005453-4057qib7 12727 13 platelets platelet NNS cord-005453-4057qib7 12727 14 decaying decay VBG cord-005453-4057qib7 12727 15 counts count NNS cord-005453-4057qib7 12727 16 after after IN cord-005453-4057qib7 12727 17 high high JJ cord-005453-4057qib7 12727 18 dose dose NN cord-005453-4057qib7 12727 19 melphalan melphalan NN cord-005453-4057qib7 12727 20 . . . cord-005453-4057qib7 12728 1 Methods method NNS cord-005453-4057qib7 12728 2 -we -we : cord-005453-4057qib7 12728 3 retrospectively retrospectively RB cord-005453-4057qib7 12728 4 analyzed analyze VBD cord-005453-4057qib7 12728 5 our -PRON- PRP$ cord-005453-4057qib7 12728 6 cohort cohort NN cord-005453-4057qib7 12728 7 of of IN cord-005453-4057qib7 12728 8 159 159 CD cord-005453-4057qib7 12728 9 multiple multiple JJ cord-005453-4057qib7 12728 10 myeloma myeloma NN cord-005453-4057qib7 12728 11 patients patient NNS cord-005453-4057qib7 12728 12 who who WP cord-005453-4057qib7 12728 13 underwent undergo VBD cord-005453-4057qib7 12728 14 HDM HDM NNP cord-005453-4057qib7 12728 15 - - HYPH cord-005453-4057qib7 12728 16 ASCT ASCT NNP cord-005453-4057qib7 12728 17 at at IN cord-005453-4057qib7 12728 18 the the DT cord-005453-4057qib7 12728 19 Hadassah Hadassah NNP cord-005453-4057qib7 12728 20 medical medical JJ cord-005453-4057qib7 12728 21 center center NN cord-005453-4057qib7 12728 22 bone bone NN cord-005453-4057qib7 12728 23 marrow marrow NN cord-005453-4057qib7 12728 24 transplant transplant NN cord-005453-4057qib7 12728 25 department department NN cord-005453-4057qib7 12728 26 , , , cord-005453-4057qib7 12728 27 between between IN cord-005453-4057qib7 12728 28 the the DT cord-005453-4057qib7 12728 29 years year NNS cord-005453-4057qib7 12728 30 2007 2007 CD cord-005453-4057qib7 12728 31 - - SYM cord-005453-4057qib7 12728 32 2015 2015 CD cord-005453-4057qib7 12728 33 . . . cord-005453-4057qib7 12729 1 The the DT cord-005453-4057qib7 12729 2 kinetics kinetic NNS cord-005453-4057qib7 12729 3 of of IN cord-005453-4057qib7 12729 4 neutrophil neutrophil NN cord-005453-4057qib7 12729 5 and and CC cord-005453-4057qib7 12729 6 platelet platelet NN cord-005453-4057qib7 12729 7 decay decay NN cord-005453-4057qib7 12729 8 during during IN cord-005453-4057qib7 12729 9 the the DT cord-005453-4057qib7 12729 10 first first JJ cord-005453-4057qib7 12729 11 two two CD cord-005453-4057qib7 12729 12 weeks week NNS cord-005453-4057qib7 12729 13 after after IN cord-005453-4057qib7 12729 14 melphalan melphalan NNP cord-005453-4057qib7 12729 15 administration administration NNP cord-005453-4057qib7 12729 16 was be VBD cord-005453-4057qib7 12729 17 fitted fit VBN cord-005453-4057qib7 12729 18 using use VBG cord-005453-4057qib7 12729 19 linear linear JJ cord-005453-4057qib7 12729 20 and and CC cord-005453-4057qib7 12729 21 exponential exponential JJ cord-005453-4057qib7 12729 22 mathematical mathematical JJ cord-005453-4057qib7 12729 23 models model NNS cord-005453-4057qib7 12729 24 . . . cord-005453-4057qib7 12730 1 Methods method NNS cord-005453-4057qib7 12730 2 : : : cord-005453-4057qib7 12730 3 we -PRON- PRP cord-005453-4057qib7 12730 4 retrospectively retrospectively RB cord-005453-4057qib7 12730 5 analyzed analyze VBD cord-005453-4057qib7 12730 6 our -PRON- PRP$ cord-005453-4057qib7 12730 7 cohort cohort NN cord-005453-4057qib7 12730 8 of of IN cord-005453-4057qib7 12730 9 159 159 CD cord-005453-4057qib7 12730 10 multiple multiple JJ cord-005453-4057qib7 12730 11 myeloma myeloma NN cord-005453-4057qib7 12730 12 patients patient NNS cord-005453-4057qib7 12730 13 who who WP cord-005453-4057qib7 12730 14 underwent undergo VBD cord-005453-4057qib7 12730 15 HDM HDM NNP cord-005453-4057qib7 12730 16 - - HYPH cord-005453-4057qib7 12730 17 ASCT ASCT NNP cord-005453-4057qib7 12730 18 at at IN cord-005453-4057qib7 12730 19 the the DT cord-005453-4057qib7 12730 20 Hadassah Hadassah NNP cord-005453-4057qib7 12730 21 medical medical JJ cord-005453-4057qib7 12730 22 center center NN cord-005453-4057qib7 12730 23 bone bone NN cord-005453-4057qib7 12730 24 marrow marrow NN cord-005453-4057qib7 12730 25 transplant transplant NN cord-005453-4057qib7 12730 26 department department NN cord-005453-4057qib7 12730 27 , , , cord-005453-4057qib7 12730 28 between between IN cord-005453-4057qib7 12730 29 the the DT cord-005453-4057qib7 12730 30 years year NNS cord-005453-4057qib7 12730 31 2007 2007 CD cord-005453-4057qib7 12730 32 - - SYM cord-005453-4057qib7 12730 33 2015 2015 CD cord-005453-4057qib7 12730 34 . . . cord-005453-4057qib7 12731 1 The the DT cord-005453-4057qib7 12731 2 kinetics kinetic NNS cord-005453-4057qib7 12731 3 of of IN cord-005453-4057qib7 12731 4 neutrophil neutrophil NN cord-005453-4057qib7 12731 5 and and CC cord-005453-4057qib7 12731 6 platelet platelet NN cord-005453-4057qib7 12731 7 decay decay NN cord-005453-4057qib7 12731 8 during during IN cord-005453-4057qib7 12731 9 the the DT cord-005453-4057qib7 12731 10 first first JJ cord-005453-4057qib7 12731 11 two two CD cord-005453-4057qib7 12731 12 weeks week NNS cord-005453-4057qib7 12731 13 after after IN cord-005453-4057qib7 12731 14 melphalan melphalan NNP cord-005453-4057qib7 12731 15 administration administration NNP cord-005453-4057qib7 12731 16 was be VBD cord-005453-4057qib7 12731 17 fitted fit VBN cord-005453-4057qib7 12731 18 using use VBG cord-005453-4057qib7 12731 19 linear linear JJ cord-005453-4057qib7 12731 20 and and CC cord-005453-4057qib7 12731 21 exponential exponential JJ cord-005453-4057qib7 12731 22 mathematical mathematical JJ cord-005453-4057qib7 12731 23 models model NNS cord-005453-4057qib7 12731 24 . . . cord-005453-4057qib7 12732 1 Results result NNS cord-005453-4057qib7 12732 2 : : : cord-005453-4057qib7 12733 1 Factors factor NNS cord-005453-4057qib7 12733 2 associated associate VBN cord-005453-4057qib7 12733 3 with with IN cord-005453-4057qib7 12733 4 prolonged prolonged JJ cord-005453-4057qib7 12733 5 OS os NN cord-005453-4057qib7 12733 6 in in IN cord-005453-4057qib7 12733 7 univariate univariate JJ cord-005453-4057qib7 12733 8 analysis analysis NN cord-005453-4057qib7 12733 9 were be VBD cord-005453-4057qib7 12733 10 : : : cord-005453-4057qib7 12734 1 ISS ISS NNP cord-005453-4057qib7 12734 2 stage stage NN cord-005453-4057qib7 12734 3 1(p=0.024 1(p=0.024 NNP cord-005453-4057qib7 12734 4 ) ) -RRB- cord-005453-4057qib7 12734 5 , , , cord-005453-4057qib7 12734 6 ≤2 ≤2 NNP cord-005453-4057qib7 12734 7 lines line NNS cord-005453-4057qib7 12734 8 of of IN cord-005453-4057qib7 12734 9 treatment treatment NN cord-005453-4057qib7 12734 10 prior prior RB cord-005453-4057qib7 12734 11 to to IN cord-005453-4057qib7 12734 12 ASCT(p ASCT(p NNP cord-005453-4057qib7 12734 13 < < XX cord-005453-4057qib7 12734 14 0.001 0.001 CD cord-005453-4057qib7 12734 15 ) ) -RRB- cord-005453-4057qib7 12734 16 , , , cord-005453-4057qib7 12734 17 favorable favorable JJ cord-005453-4057qib7 12734 18 cytogenetics(p=0.004 cytogenetics(p=0.004 NNP cord-005453-4057qib7 12734 19 ) ) -RRB- cord-005453-4057qib7 12734 20 , , , cord-005453-4057qib7 12734 21 response response NN cord-005453-4057qib7 12734 22 to to IN cord-005453-4057qib7 12734 23 treatment treatment NN cord-005453-4057qib7 12734 24 ( ( -LRB- cord-005453-4057qib7 12734 25 PR pr NN cord-005453-4057qib7 12734 26 or or CC cord-005453-4057qib7 12734 27 better well JJR cord-005453-4057qib7 12734 28 , , , cord-005453-4057qib7 12734 29 p=0.046 p=0.046 NNS cord-005453-4057qib7 12734 30 ) ) -RRB- cord-005453-4057qib7 12734 31 and and CC cord-005453-4057qib7 12734 32 rapid rapid JJ cord-005453-4057qib7 12734 33 linear linear JJ cord-005453-4057qib7 12734 34 neutrophil neutrophil NN cord-005453-4057qib7 12734 35 decay decay NN cord-005453-4057qib7 12734 36 ( ( -LRB- cord-005453-4057qib7 12734 37 p p NN cord-005453-4057qib7 12734 38 = = SYM cord-005453-4057qib7 12734 39 0.046 0.046 CD cord-005453-4057qib7 12734 40 ) ) -RRB- cord-005453-4057qib7 12734 41 . . . cord-005453-4057qib7 12735 1 In in IN cord-005453-4057qib7 12735 2 multivariate multivariate JJ cord-005453-4057qib7 12735 3 analysis analysis NN cord-005453-4057qib7 12735 4 , , , cord-005453-4057qib7 12735 5 only only RB cord-005453-4057qib7 12735 6 ≤2 ≤2 NNP cord-005453-4057qib7 12735 7 lines line NNS cord-005453-4057qib7 12735 8 of of IN cord-005453-4057qib7 12735 9 treatment treatment NN cord-005453-4057qib7 12735 10 before before IN cord-005453-4057qib7 12735 11 HDM HDM NNP cord-005453-4057qib7 12735 12 - - HYPH cord-005453-4057qib7 12735 13 ASCT ASCT NNP cord-005453-4057qib7 12735 14 and and CC cord-005453-4057qib7 12735 15 rapid rapid JJ cord-005453-4057qib7 12735 16 linear linear JJ cord-005453-4057qib7 12735 17 neutrophils neutrophil NNS cord-005453-4057qib7 12735 18 count count VBP cord-005453-4057qib7 12735 19 decay decay NN cord-005453-4057qib7 12735 20 remained remain VBD cord-005453-4057qib7 12735 21 statistically statistically RB cord-005453-4057qib7 12735 22 significant significant JJ cord-005453-4057qib7 12735 23 for for IN cord-005453-4057qib7 12735 24 OS os NN cord-005453-4057qib7 12735 25 prolongation prolongation NN cord-005453-4057qib7 12735 26 . . . cord-005453-4057qib7 12736 1 No no DT cord-005453-4057qib7 12736 2 predictive predictive JJ cord-005453-4057qib7 12736 3 threshold threshold NN cord-005453-4057qib7 12736 4 value value NN cord-005453-4057qib7 12736 5 of of IN cord-005453-4057qib7 12736 6 the the DT cord-005453-4057qib7 12736 7 neutrophil neutrophil NN cord-005453-4057qib7 12736 8 decay decay NN cord-005453-4057qib7 12736 9 incline incline NN cord-005453-4057qib7 12736 10 was be VBD cord-005453-4057qib7 12736 11 found find VBN cord-005453-4057qib7 12736 12 . . . cord-005453-4057qib7 12737 1 Improved Improved NNP cord-005453-4057qib7 12737 2 PFS PFS NNP cord-005453-4057qib7 12737 3 was be VBD cord-005453-4057qib7 12737 4 associated associate VBN cord-005453-4057qib7 12737 5 with with IN cord-005453-4057qib7 12737 6 ≤2 ≤2 NNP cord-005453-4057qib7 12737 7 lines line NNS cord-005453-4057qib7 12737 8 of of IN cord-005453-4057qib7 12737 9 treatment treatment NN cord-005453-4057qib7 12737 10 prior prior RB cord-005453-4057qib7 12737 11 to to IN cord-005453-4057qib7 12737 12 ASCT ASCT NNP cord-005453-4057qib7 12737 13 , , , cord-005453-4057qib7 12737 14 and and CC cord-005453-4057qib7 12737 15 the the DT cord-005453-4057qib7 12737 16 response response NN cord-005453-4057qib7 12737 17 status status NN cord-005453-4057qib7 12737 18 after after IN cord-005453-4057qib7 12737 19 HDM HDM NNP cord-005453-4057qib7 12737 20 - - HYPH cord-005453-4057qib7 12737 21 ASCT ASCT NNP cord-005453-4057qib7 12737 22 ( ( -LRB- cord-005453-4057qib7 12737 23 p=0.003 p=0.003 NNP cord-005453-4057qib7 12737 24 , , , cord-005453-4057qib7 12737 25 p=0.019 p=0.019 NNP cord-005453-4057qib7 12737 26 ) ) -RRB- cord-005453-4057qib7 12737 27 . . . cord-005453-4057qib7 12738 1 Additionally additionally RB cord-005453-4057qib7 12738 2 , , , cord-005453-4057qib7 12738 3 toxicity toxicity NN cord-005453-4057qib7 12738 4 evaluation evaluation NN cord-005453-4057qib7 12738 5 showed show VBD cord-005453-4057qib7 12738 6 prolonged prolonged JJ cord-005453-4057qib7 12738 7 neutropenia neutropenia NN cord-005453-4057qib7 12738 8 to to TO cord-005453-4057qib7 12738 9 be be VB cord-005453-4057qib7 12738 10 associated associate VBN cord-005453-4057qib7 12738 11 with with IN cord-005453-4057qib7 12738 12 inferior inferior JJ cord-005453-4057qib7 12738 13 OS os NN cord-005453-4057qib7 12738 14 ( ( -LRB- cord-005453-4057qib7 12738 15 HR hr NN cord-005453-4057qib7 12738 16 = = SYM cord-005453-4057qib7 12738 17 1.139 1.139 CD cord-005453-4057qib7 12738 18 , , , cord-005453-4057qib7 12738 19 p=0.03 p=0.03 NN cord-005453-4057qib7 12738 20 ) ) -RRB- cord-005453-4057qib7 12738 21 and and CC cord-005453-4057qib7 12738 22 rapid rapid JJ cord-005453-4057qib7 12738 23 exponential exponential JJ cord-005453-4057qib7 12738 24 decay decay NN cord-005453-4057qib7 12738 25 of of IN cord-005453-4057qib7 12738 26 neutrophil neutrophil NN cord-005453-4057qib7 12738 27 counts count NNS cord-005453-4057qib7 12738 28 to to TO cord-005453-4057qib7 12738 29 correlate correlate VB cord-005453-4057qib7 12738 30 with with IN cord-005453-4057qib7 12738 31 higher high JJR cord-005453-4057qib7 12738 32 incidence incidence NN cord-005453-4057qib7 12738 33 of of IN cord-005453-4057qib7 12738 34 mucositis mucositis NNP cord-005453-4057qib7 12738 35 ( ( -LRB- cord-005453-4057qib7 12738 36 p p NN cord-005453-4057qib7 12738 37 = = SYM cord-005453-4057qib7 12738 38 0.013 0.013 CD cord-005453-4057qib7 12738 39 ) ) -RRB- cord-005453-4057qib7 12738 40 . . . cord-005453-4057qib7 12739 1 Fast fast JJ cord-005453-4057qib7 12739 2 platelet platelet NN cord-005453-4057qib7 12739 3 decay decay NN cord-005453-4057qib7 12739 4 was be VBD cord-005453-4057qib7 12739 5 associated associate VBN cord-005453-4057qib7 12739 6 with with IN cord-005453-4057qib7 12739 7 delayed delayed JJ cord-005453-4057qib7 12739 8 platelet platelet NN cord-005453-4057qib7 12739 9 engraftment engraftment NN cord-005453-4057qib7 12739 10 ( ( -LRB- cord-005453-4057qib7 12739 11 p p NN cord-005453-4057qib7 12739 12 < < XX cord-005453-4057qib7 12739 13 0.01 0.01 CD cord-005453-4057qib7 12739 14 ) ) -RRB- cord-005453-4057qib7 12740 1 Conclusions conclusion NNS cord-005453-4057qib7 12740 2 : : : cord-005453-4057qib7 12740 3 We -PRON- PRP cord-005453-4057qib7 12740 4 have have VBP cord-005453-4057qib7 12740 5 shown show VBN cord-005453-4057qib7 12740 6 that that IN cord-005453-4057qib7 12740 7 rapid rapid JJ cord-005453-4057qib7 12740 8 linear linear JJ cord-005453-4057qib7 12740 9 decay decay NN cord-005453-4057qib7 12740 10 in in IN cord-005453-4057qib7 12740 11 neutrophil neutrophil NN cord-005453-4057qib7 12740 12 counts count NNS cord-005453-4057qib7 12740 13 predicts predict VBZ cord-005453-4057qib7 12740 14 better well JJR cord-005453-4057qib7 12740 15 OS os NN cord-005453-4057qib7 12740 16 without without IN cord-005453-4057qib7 12740 17 a a DT cord-005453-4057qib7 12740 18 significant significant JJ cord-005453-4057qib7 12740 19 benefit benefit NN cord-005453-4057qib7 12740 20 in in IN cord-005453-4057qib7 12740 21 PFS PFS NNP cord-005453-4057qib7 12740 22 in in IN cord-005453-4057qib7 12740 23 MM MM NNP cord-005453-4057qib7 12740 24 patients patient NNS cord-005453-4057qib7 12740 25 undergoing undergo VBG cord-005453-4057qib7 12740 26 HDM HDM NNP cord-005453-4057qib7 12740 27 - - HYPH cord-005453-4057qib7 12740 28 ASCT ASCT NNP cord-005453-4057qib7 12740 29 . . . cord-005453-4057qib7 12741 1 This this DT cord-005453-4057qib7 12741 2 discrepancy discrepancy NN cord-005453-4057qib7 12741 3 might may MD cord-005453-4057qib7 12741 4 reflect reflect VB cord-005453-4057qib7 12741 5 the the DT cord-005453-4057qib7 12741 6 problematic problematic JJ cord-005453-4057qib7 12741 7 estimation estimation NN cord-005453-4057qib7 12741 8 in in IN cord-005453-4057qib7 12741 9 a a DT cord-005453-4057qib7 12741 10 retrospective retrospective JJ cord-005453-4057qib7 12741 11 analysis analysis NN cord-005453-4057qib7 12741 12 of of IN cord-005453-4057qib7 12741 13 PFS PFS NNP cord-005453-4057qib7 12741 14 . . . cord-005453-4057qib7 12742 1 Rapid rapid JJ cord-005453-4057qib7 12742 2 decrease decrease NN cord-005453-4057qib7 12742 3 in in IN cord-005453-4057qib7 12742 4 neutrophils neutrophil NNS cord-005453-4057qib7 12742 5 and and CC cord-005453-4057qib7 12742 6 platelet platelet NN cord-005453-4057qib7 12742 7 counts count NNS cord-005453-4057qib7 12742 8 was be VBD cord-005453-4057qib7 12742 9 associated associate VBN cord-005453-4057qib7 12742 10 with with IN cord-005453-4057qib7 12742 11 more more JJR cord-005453-4057qib7 12742 12 toxicity toxicity NN cord-005453-4057qib7 12742 13 : : : cord-005453-4057qib7 12742 14 higher high JJR cord-005453-4057qib7 12742 15 mucositis mucositis JJ cord-005453-4057qib7 12742 16 rate rate NN cord-005453-4057qib7 12742 17 and and CC cord-005453-4057qib7 12742 18 delayed delay VBN cord-005453-4057qib7 12742 19 engraftment engraftment NN cord-005453-4057qib7 12742 20 , , , cord-005453-4057qib7 12742 21 respectively respectively RB cord-005453-4057qib7 12742 22 . . . cord-005453-4057qib7 12743 1 Therefore therefore RB cord-005453-4057qib7 12743 2 a a DT cord-005453-4057qib7 12743 3 rapid rapid JJ cord-005453-4057qib7 12743 4 decay decay NN cord-005453-4057qib7 12743 5 of of IN cord-005453-4057qib7 12743 6 blood blood NN cord-005453-4057qib7 12743 7 counts count NNS cord-005453-4057qib7 12743 8 after after IN cord-005453-4057qib7 12743 9 HDM HDM NNP cord-005453-4057qib7 12743 10 - - HYPH cord-005453-4057qib7 12743 11 ASCT ASCT NNP cord-005453-4057qib7 12743 12 appears appear VBZ cord-005453-4057qib7 12743 13 to to TO cord-005453-4057qib7 12743 14 be be VB cord-005453-4057qib7 12743 15 an an DT cord-005453-4057qib7 12743 16 in in IN cord-005453-4057qib7 12743 17 - - HYPH cord-005453-4057qib7 12743 18 vivo vivo NN cord-005453-4057qib7 12743 19 phamacodynamic phamacodynamic JJ cord-005453-4057qib7 12743 20 marker marker NN cord-005453-4057qib7 12743 21 of of IN cord-005453-4057qib7 12743 22 higher high JJR cord-005453-4057qib7 12743 23 efficacy efficacy NN cord-005453-4057qib7 12743 24 and and CC cord-005453-4057qib7 12743 25 toxicity toxicity NN cord-005453-4057qib7 12743 26 of of IN cord-005453-4057qib7 12743 27 melphalan melphalan NNP cord-005453-4057qib7 12743 28 . . . cord-005453-4057qib7 12744 1 Disclosure disclosure NN cord-005453-4057qib7 12744 2 : : : cord-005453-4057qib7 12744 3 Nothing nothing NN cord-005453-4057qib7 12744 4 to to TO cord-005453-4057qib7 12744 5 declare declare VB cord-005453-4057qib7 12744 6 P564 p564 NN cord-005453-4057qib7 12745 1 Do do VBP cord-005453-4057qib7 12745 2 we -PRON- PRP cord-005453-4057qib7 12745 3 need need VB cord-005453-4057qib7 12745 4 to to TO cord-005453-4057qib7 12745 5 freeze freeze VB cord-005453-4057qib7 12745 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 12745 7 cells cell NNS cord-005453-4057qib7 12745 8 for for IN cord-005453-4057qib7 12745 9 autotransplants autotransplant NNS cord-005453-4057qib7 12745 10 in in IN cord-005453-4057qib7 12745 11 patients patient NNS cord-005453-4057qib7 12745 12 with with IN cord-005453-4057qib7 12745 13 myeloma myeloma NN cord-005453-4057qib7 12745 14 conditioned condition VBN cord-005453-4057qib7 12745 15 with with IN cord-005453-4057qib7 12745 16 melphalan melphalan NNP cord-005453-4057qib7 12745 17 ? ? . cord-005453-4057qib7 12746 1 Daniel Daniel NNP cord-005453-4057qib7 12746 2 Garcia Garcia NNP cord-005453-4057qib7 12746 3 Belmonte Belmonte NNP cord-005453-4057qib7 12746 4 1 1 CD cord-005453-4057qib7 12746 5 , , , cord-005453-4057qib7 12747 1 Beatriz Beatriz NNP cord-005453-4057qib7 12747 2 Aguado Aguado NNP cord-005453-4057qib7 12747 3 Bueno Bueno NNP cord-005453-4057qib7 12747 4 1 1 CD cord-005453-4057qib7 12747 5 , , , cord-005453-4057qib7 12747 6 Miguel Miguel NNP cord-005453-4057qib7 12747 7 Herrero Herrero NNP cord-005453-4057qib7 12747 8 Coderch Coderch NNP cord-005453-4057qib7 12747 9 1 1 CD cord-005453-4057qib7 12747 10 , , , cord-005453-4057qib7 12747 11 Rafael Rafael NNP cord-005453-4057qib7 12747 12 de de NNP cord-005453-4057qib7 12747 13 la la NNP cord-005453-4057qib7 12747 14 Camara Camara NNP cord-005453-4057qib7 12747 15 1 1 CD cord-005453-4057qib7 12747 16 Background Background NNP cord-005453-4057qib7 12747 17 : : : cord-005453-4057qib7 12748 1 Multiple multiple JJ cord-005453-4057qib7 12748 2 myeloma myeloma NN cord-005453-4057qib7 12748 3 ( ( -LRB- cord-005453-4057qib7 12748 4 MM MM NNP cord-005453-4057qib7 12748 5 ) ) -RRB- cord-005453-4057qib7 12748 6 is be VBZ cord-005453-4057qib7 12748 7 the the DT cord-005453-4057qib7 12748 8 most most RBS cord-005453-4057qib7 12748 9 frequent frequent JJ cord-005453-4057qib7 12748 10 indication indication NN cord-005453-4057qib7 12748 11 of of IN cord-005453-4057qib7 12748 12 auto auto NN cord-005453-4057qib7 12748 13 - - HYPH cord-005453-4057qib7 12748 14 HSCT HSCT NNP cord-005453-4057qib7 12748 15 , , , cord-005453-4057qib7 12748 16 representing represent VBG cord-005453-4057qib7 12748 17 51 51 CD cord-005453-4057qib7 12748 18 % % NN cord-005453-4057qib7 12748 19 of of IN cord-005453-4057qib7 12748 20 all all DT cord-005453-4057qib7 12748 21 auto auto NN cord-005453-4057qib7 12748 22 - - HYPH cord-005453-4057qib7 12748 23 HSCT HSCT NNP cord-005453-4057qib7 12748 24 in in IN cord-005453-4057qib7 12748 25 2016 2016 CD cord-005453-4057qib7 12749 1 ( ( -LRB- cord-005453-4057qib7 12749 2 Passweg Passweg NNP cord-005453-4057qib7 12749 3 JR JR NNP cord-005453-4057qib7 12749 4 . . . cord-005453-4057qib7 12750 1 BMT BMT NNP cord-005453-4057qib7 12750 2 2018 2018 CD cord-005453-4057qib7 12750 3 ; ; : cord-005453-4057qib7 12750 4 53:1139 53:1139 CD cord-005453-4057qib7 12750 5 - - SYM cord-005453-4057qib7 12750 6 48 48 CD cord-005453-4057qib7 12750 7 ) ) -RRB- cord-005453-4057qib7 12750 8 . . . cord-005453-4057qib7 12751 1 Nearly nearly RB cord-005453-4057qib7 12751 2 all all DT cord-005453-4057qib7 12751 3 are be VBP cord-005453-4057qib7 12751 4 performed perform VBN cord-005453-4057qib7 12751 5 with with IN cord-005453-4057qib7 12751 6 peripheral peripheral JJ cord-005453-4057qib7 12751 7 blood blood NN cord-005453-4057qib7 12751 8 progenitor progenitor NN cord-005453-4057qib7 12751 9 cells cell NNS cord-005453-4057qib7 12751 10 ( ( -LRB- cord-005453-4057qib7 12751 11 PBPC PBPC NNP cord-005453-4057qib7 12751 12 ) ) -RRB- cord-005453-4057qib7 12751 13 , , , cord-005453-4057qib7 12751 14 and and CC cord-005453-4057qib7 12751 15 Melphalan Melphalan NNP cord-005453-4057qib7 12751 16 200 200 CD cord-005453-4057qib7 12751 17 mg mg NNP cord-005453-4057qib7 12751 18 / / SYM cord-005453-4057qib7 12751 19 m2 m2 NNP cord-005453-4057qib7 12751 20 is be VBZ cord-005453-4057qib7 12751 21 considered consider VBN cord-005453-4057qib7 12751 22 the the DT cord-005453-4057qib7 12751 23 gold gold JJ cord-005453-4057qib7 12751 24 standard standard JJ cord-005453-4057qib7 12751 25 conditioning conditioning NN cord-005453-4057qib7 12751 26 regimen regimen NN cord-005453-4057qib7 12751 27 . . . cord-005453-4057qib7 12752 1 The the DT cord-005453-4057qib7 12752 2 standard standard JJ cord-005453-4057qib7 12752 3 procedure procedure NN cord-005453-4057qib7 12752 4 consists consist VBZ cord-005453-4057qib7 12752 5 in in IN cord-005453-4057qib7 12752 6 obtaining obtain VBG cord-005453-4057qib7 12752 7 progenitors progenitor NNS cord-005453-4057qib7 12752 8 , , , cord-005453-4057qib7 12752 9 cryopreserved cryopreserve VBN cord-005453-4057qib7 12752 10 with with IN cord-005453-4057qib7 12752 11 Dimethyl dimethyl NN cord-005453-4057qib7 12752 12 sulfoxide sulfoxide NN cord-005453-4057qib7 12752 13 ( ( -LRB- cord-005453-4057qib7 12752 14 DMSO DMSO NNP cord-005453-4057qib7 12752 15 ) ) -RRB- cord-005453-4057qib7 12752 16 and and CC cord-005453-4057qib7 12752 17 stored store VBN cord-005453-4057qib7 12752 18 and and CC cord-005453-4057qib7 12752 19 subsequently subsequently RB cord-005453-4057qib7 12752 20 thawed thaw VBN cord-005453-4057qib7 12752 21 and and CC cord-005453-4057qib7 12752 22 re re VBN cord-005453-4057qib7 12752 23 - - VBN cord-005453-4057qib7 12752 24 infused infuse VBN cord-005453-4057qib7 12752 25 in in IN cord-005453-4057qib7 12752 26 the the DT cord-005453-4057qib7 12752 27 patient patient NN cord-005453-4057qib7 12752 28 on on IN cord-005453-4057qib7 12752 29 day day NN cord-005453-4057qib7 12752 30 0 0 CD cord-005453-4057qib7 12752 31 . . . cord-005453-4057qib7 12753 1 The the DT cord-005453-4057qib7 12753 2 procedure procedure NN cord-005453-4057qib7 12753 3 of of IN cord-005453-4057qib7 12753 4 cryopreservation cryopreservation NN cord-005453-4057qib7 12753 5 is be VBZ cord-005453-4057qib7 12753 6 expensive expensive JJ cord-005453-4057qib7 12753 7 and and CC cord-005453-4057qib7 12753 8 has have VBZ cord-005453-4057qib7 12753 9 some some DT cord-005453-4057qib7 12753 10 inherent inherent JJ cord-005453-4057qib7 12753 11 toxicities toxicity NNS cord-005453-4057qib7 12753 12 ( ( -LRB- cord-005453-4057qib7 12753 13 DMSO DMSO NNP cord-005453-4057qib7 12753 14 ) ) -RRB- cord-005453-4057qib7 12753 15 and and CC cord-005453-4057qib7 12753 16 loss loss NN cord-005453-4057qib7 12753 17 of of IN cord-005453-4057qib7 12753 18 cells cell NNS cord-005453-4057qib7 12753 19 during during IN cord-005453-4057qib7 12753 20 the the DT cord-005453-4057qib7 12753 21 procedure procedure NN cord-005453-4057qib7 12753 22 . . . cord-005453-4057qib7 12754 1 Several several JJ cord-005453-4057qib7 12754 2 groups group NNS cord-005453-4057qib7 12754 3 have have VBP cord-005453-4057qib7 12754 4 used use VBN cord-005453-4057qib7 12754 5 non non JJ cord-005453-4057qib7 12754 6 - - JJ cord-005453-4057qib7 12754 7 cryopreserved cryopreserved JJ cord-005453-4057qib7 12754 8 progenitors progenitor NNS cord-005453-4057qib7 12754 9 showing show VBG cord-005453-4057qib7 12754 10 some some DT cord-005453-4057qib7 12754 11 benefits benefit NNS cord-005453-4057qib7 12754 12 compared compare VBN cord-005453-4057qib7 12754 13 with with IN cord-005453-4057qib7 12754 14 cryopreserved cryopreserved JJ cord-005453-4057qib7 12754 15 transplants transplant NNS cord-005453-4057qib7 12754 16 , , , cord-005453-4057qib7 12754 17 mainly mainly RB cord-005453-4057qib7 12754 18 a a DT cord-005453-4057qib7 12754 19 faster fast JJR cord-005453-4057qib7 12754 20 engraftment engraftment NN cord-005453-4057qib7 12754 21 and and CC cord-005453-4057qib7 12754 22 a a DT cord-005453-4057qib7 12754 23 shorter short JJR cord-005453-4057qib7 12754 24 length length NN cord-005453-4057qib7 12754 25 of of IN cord-005453-4057qib7 12754 26 hospitalization hospitalization NN cord-005453-4057qib7 12754 27 . . . cord-005453-4057qib7 12755 1 Objective objective NN cord-005453-4057qib7 12755 2 : : : cord-005453-4057qib7 12755 3 To to TO cord-005453-4057qib7 12755 4 compare compare VB cord-005453-4057qib7 12755 5 noncryopreserved noncryopreserve VBN cord-005453-4057qib7 12755 6 vs vs IN cord-005453-4057qib7 12755 7 cryopreserved cryopreserved JJ cord-005453-4057qib7 12755 8 auto auto NN cord-005453-4057qib7 12755 9 - - HYPH cord-005453-4057qib7 12755 10 HSCT HSCT NNP cord-005453-4057qib7 12755 11 in in IN cord-005453-4057qib7 12755 12 MM MM NNP cord-005453-4057qib7 12755 13 Methods method NNS cord-005453-4057qib7 12755 14 : : : cord-005453-4057qib7 12755 15 We -PRON- PRP cord-005453-4057qib7 12755 16 perform perform VBP cord-005453-4057qib7 12755 17 an an DT cord-005453-4057qib7 12755 18 unicentric unicentric JJ cord-005453-4057qib7 12755 19 , , , cord-005453-4057qib7 12755 20 retrospective retrospective JJ cord-005453-4057qib7 12755 21 study study NN cord-005453-4057qib7 12755 22 on on IN cord-005453-4057qib7 12755 23 23 23 CD cord-005453-4057qib7 12755 24 consecutive consecutive JJ cord-005453-4057qib7 12755 25 first first JJ cord-005453-4057qib7 12755 26 auto auto NN cord-005453-4057qib7 12755 27 - - HYPH cord-005453-4057qib7 12755 28 HSCT HSCT NNP cord-005453-4057qib7 12755 29 MM MM NNP cord-005453-4057qib7 12755 30 patients patient NNS cord-005453-4057qib7 12755 31 transplanted transplant VBN cord-005453-4057qib7 12755 32 with with IN cord-005453-4057qib7 12755 33 PBPC PBPC NNP cord-005453-4057qib7 12755 34 between between IN cord-005453-4057qib7 12755 35 Nov-2011 Nov-2011 NNP cord-005453-4057qib7 12755 36 and and CC cord-005453-4057qib7 12755 37 Oct-2018 Oct-2018 NNP cord-005453-4057qib7 12755 38 , , , cord-005453-4057qib7 12755 39 and and CC cord-005453-4057qib7 12755 40 conditioned condition VBN cord-005453-4057qib7 12755 41 with with IN cord-005453-4057qib7 12755 42 high high JJ cord-005453-4057qib7 12755 43 dose dose NN cord-005453-4057qib7 12755 44 melphalan melphalan NNP cord-005453-4057qib7 12755 45 ( ( -LRB- cord-005453-4057qib7 12755 46 200 200 CD cord-005453-4057qib7 12755 47 mg mg NNP cord-005453-4057qib7 12755 48 / / SYM cord-005453-4057qib7 12755 49 m2 m2 NNP cord-005453-4057qib7 12755 50 ) ) -RRB- cord-005453-4057qib7 12755 51 . . . cord-005453-4057qib7 12756 1 The the DT cord-005453-4057qib7 12756 2 median median JJ cord-005453-4057qib7 12756 3 follow follow NN cord-005453-4057qib7 12756 4 - - HYPH cord-005453-4057qib7 12756 5 up up NN cord-005453-4057qib7 12756 6 was be VBD cord-005453-4057qib7 12756 7 1620 1620 CD cord-005453-4057qib7 12756 8 days day NNS cord-005453-4057qib7 12757 1 ( ( -LRB- cord-005453-4057qib7 12757 2 range range NN cord-005453-4057qib7 12757 3 : : : cord-005453-4057qib7 12757 4 44 44 CD cord-005453-4057qib7 12757 5 - - HYPH cord-005453-4057qib7 12757 6 2413 2413 CD cord-005453-4057qib7 12757 7 ) ) -RRB- cord-005453-4057qib7 12757 8 . . . cord-005453-4057qib7 12758 1 9 9 CD cord-005453-4057qib7 12758 2 patients patient NNS cord-005453-4057qib7 12758 3 received receive VBD cord-005453-4057qib7 12758 4 non non JJ cord-005453-4057qib7 12758 5 - - JJ cord-005453-4057qib7 12758 6 cryopreserved cryopreserved JJ cord-005453-4057qib7 12758 7 and and CC cord-005453-4057qib7 12758 8 14 14 CD cord-005453-4057qib7 12758 9 cryopreserved cryopreserve VBN cord-005453-4057qib7 12758 10 auto auto NN cord-005453-4057qib7 12758 11 - - HYPH cord-005453-4057qib7 12758 12 HSCT HSCT NNP cord-005453-4057qib7 12758 13 . . . cord-005453-4057qib7 12759 1 Patients patient NNS cord-005453-4057qib7 12759 2 characteristics characteristic NNS cord-005453-4057qib7 12759 3 , , , cord-005453-4057qib7 12759 4 without without IN cord-005453-4057qib7 12759 5 differences difference NNS cord-005453-4057qib7 12759 6 between between IN cord-005453-4057qib7 12759 7 non non JJ cord-005453-4057qib7 12759 8 - - JJ cord-005453-4057qib7 12759 9 cryopreserved cryopreserved JJ cord-005453-4057qib7 12759 10 vs vs IN cord-005453-4057qib7 12759 11 cryopreserved cryopreserve VBN cord-005453-4057qib7 12759 12 : : : cord-005453-4057qib7 12759 13 women woman NNS cord-005453-4057qib7 12759 14 / / SYM cord-005453-4057qib7 12759 15 men man NNS cord-005453-4057qib7 12759 16 ( ( -LRB- cord-005453-4057qib7 12759 17 15/8 15/8 NNP cord-005453-4057qib7 12759 18 ) ) -RRB- cord-005453-4057qib7 12759 19 ; ; : cord-005453-4057qib7 12759 20 median median JJ cord-005453-4057qib7 12759 21 age age NN cord-005453-4057qib7 12759 22 was be VBD cord-005453-4057qib7 12759 23 65 65 CD cord-005453-4057qib7 12759 24 years year NNS cord-005453-4057qib7 12760 1 ( ( -LRB- cord-005453-4057qib7 12760 2 range range NN cord-005453-4057qib7 12760 3 49 49 CD cord-005453-4057qib7 12760 4 - - SYM cord-005453-4057qib7 12760 5 72 72 CD cord-005453-4057qib7 12760 6 ) ) -RRB- cord-005453-4057qib7 12760 7 ; ; : cord-005453-4057qib7 12760 8 in in IN cord-005453-4057qib7 12760 9 the the DT cord-005453-4057qib7 12760 10 majority majority NN cord-005453-4057qib7 12760 11 auto auto NN cord-005453-4057qib7 12760 12 - - HYPH cord-005453-4057qib7 12760 13 HSCT HSCT NNP cord-005453-4057qib7 12760 14 was be VBD cord-005453-4057qib7 12760 15 done do VBN cord-005453-4057qib7 12760 16 as as IN cord-005453-4057qib7 12760 17 consolidation consolidation NN cord-005453-4057qib7 12760 18 after after IN cord-005453-4057qib7 12760 19 first first JJ cord-005453-4057qib7 12760 20 line line NN cord-005453-4057qib7 12760 21 therapy therapy NN cord-005453-4057qib7 12760 22 ( ( -LRB- cord-005453-4057qib7 12760 23 78 78 CD cord-005453-4057qib7 12760 24 % % NN cord-005453-4057qib7 12760 25 ) ) -RRB- cord-005453-4057qib7 12760 26 ; ; : cord-005453-4057qib7 12760 27 year year NN cord-005453-4057qib7 12760 28 of of IN cord-005453-4057qib7 12760 29 transplant transplant NN cord-005453-4057qib7 12760 30 ≤2014 ≤2014 NNS cord-005453-4057qib7 12760 31 ( ( -LRB- cord-005453-4057qib7 12760 32 61 61 CD cord-005453-4057qib7 12760 33 % % NN cord-005453-4057qib7 12760 34 ) ) -RRB- cord-005453-4057qib7 12760 35 , , , cord-005453-4057qib7 12760 36 ≥2015 ≥2015 JJ cord-005453-4057qib7 12760 37 ( ( -LRB- cord-005453-4057qib7 12760 38 39 39 CD cord-005453-4057qib7 12760 39 % % NN cord-005453-4057qib7 12760 40 ) ) -RRB- cord-005453-4057qib7 12760 41 . . . cord-005453-4057qib7 12761 1 The the DT cord-005453-4057qib7 12761 2 number number NN cord-005453-4057qib7 12761 3 of of IN cord-005453-4057qib7 12761 4 infused infuse VBN cord-005453-4057qib7 12761 5 CD34 CD34 NNP cord-005453-4057qib7 12761 6 cells cell NNS cord-005453-4057qib7 12761 7 were be VBD cord-005453-4057qib7 12761 8 not not RB cord-005453-4057qib7 12761 9 different different JJ cord-005453-4057qib7 12761 10 : : : cord-005453-4057qib7 12761 11 median median NN cord-005453-4057qib7 12761 12 3.5 3.5 CD cord-005453-4057qib7 12761 13 x10 x10 NN cord-005453-4057qib7 12761 14 /kg /kg . cord-005453-4057qib7 12761 15 ( ( -LRB- cord-005453-4057qib7 12761 16 range range VBP cord-005453-4057qib7 12761 17 1.7 1.7 CD cord-005453-4057qib7 12761 18 - - SYM cord-005453-4057qib7 12761 19 11.5 11.5 CD cord-005453-4057qib7 12761 20 ) ) -RRB- cord-005453-4057qib7 12761 21 in in IN cord-005453-4057qib7 12761 22 noncryopreserved noncryopreserve VBN cord-005453-4057qib7 12761 23 patients patient NNS cord-005453-4057qib7 12761 24 and and CC cord-005453-4057qib7 12761 25 3.75 3.75 CD cord-005453-4057qib7 12761 26 x10 x10 NN cord-005453-4057qib7 12762 1 /kg /kg . cord-005453-4057qib7 12763 1 ( ( -LRB- cord-005453-4057qib7 12763 2 range range NNP cord-005453-4057qib7 12763 3 2.1 2.1 CD cord-005453-4057qib7 12763 4 - - SYM cord-005453-4057qib7 12763 5 17 17 CD cord-005453-4057qib7 12763 6 ) ) -RRB- cord-005453-4057qib7 12763 7 in in IN cord-005453-4057qib7 12763 8 cryopreserved cryopreserve VBN cord-005453-4057qib7 12763 9 patients patient NNS cord-005453-4057qib7 12763 10 . . . cord-005453-4057qib7 12764 1 Results result NNS cord-005453-4057qib7 12764 2 : : : cord-005453-4057qib7 12765 1 We -PRON- PRP cord-005453-4057qib7 12765 2 didn´t didn´t TO cord-005453-4057qib7 12765 3 observe observe VB cord-005453-4057qib7 12765 4 significant significant JJ cord-005453-4057qib7 12765 5 differences difference NNS cord-005453-4057qib7 12765 6 in in IN cord-005453-4057qib7 12765 7 the the DT cord-005453-4057qib7 12765 8 day day NN cord-005453-4057qib7 12765 9 of of IN cord-005453-4057qib7 12765 10 engraftment engraftment NN cord-005453-4057qib7 12765 11 between between IN cord-005453-4057qib7 12765 12 non non JJ cord-005453-4057qib7 12765 13 - - JJ cord-005453-4057qib7 12765 14 cryopreserved cryopreserved JJ cord-005453-4057qib7 12765 15 vs vs IN cord-005453-4057qib7 12765 16 cryopreserved cryopreserve VBN cord-005453-4057qib7 12765 17 although although IN cord-005453-4057qib7 12765 18 always always RB cord-005453-4057qib7 12765 19 was be VBD cord-005453-4057qib7 12765 20 a a DT cord-005453-4057qib7 12765 21 little little JJ cord-005453-4057qib7 12765 22 bit bit NN cord-005453-4057qib7 12765 23 faster fast RBR cord-005453-4057qib7 12765 24 in in IN cord-005453-4057qib7 12765 25 the the DT cord-005453-4057qib7 12765 26 noncryopreserved noncryopreserved JJ cord-005453-4057qib7 12765 27 group group NN cord-005453-4057qib7 12765 28 with with IN cord-005453-4057qib7 12765 29 a a DT cord-005453-4057qib7 12765 30 tendency tendency NN cord-005453-4057qib7 12765 31 to to TO cord-005453-4057qib7 12765 32 faster fast JJR cord-005453-4057qib7 12765 33 platelet platelet NN cord-005453-4057qib7 12765 34 engraftment engraftment NN cord-005453-4057qib7 12765 35 ( ( -LRB- cord-005453-4057qib7 12765 36 > > NFP cord-005453-4057qib7 12765 37 50000 50000 CD cord-005453-4057qib7 12765 38 / / SYM cord-005453-4057qib7 12765 39 mm3 mm3 NNS cord-005453-4057qib7 12765 40 ) ) -RRB- cord-005453-4057qib7 12765 41 : : : cord-005453-4057qib7 12765 42 > > XX cord-005453-4057qib7 12766 1 20000 20000 CD cord-005453-4057qib7 12766 2 platelets platelet NNS cord-005453-4057qib7 12766 3 / / SYM cord-005453-4057qib7 12766 4 mm3 mm3 NNS cord-005453-4057qib7 12766 5 ( ( -LRB- cord-005453-4057qib7 12766 6 median median JJ cord-005453-4057qib7 12766 7 day day NN cord-005453-4057qib7 12766 8 : : : cord-005453-4057qib7 12767 1 12 12 CD cord-005453-4057qib7 12767 2 vs vs IN cord-005453-4057qib7 12767 3 12.5 12.5 CD cord-005453-4057qib7 12767 4 , , , cord-005453-4057qib7 12767 5 P p NN cord-005453-4057qib7 12767 6 0.2 0.2 CD cord-005453-4057qib7 12767 7 ) ) -RRB- cord-005453-4057qib7 12767 8 , , , cord-005453-4057qib7 12767 9 > > XX cord-005453-4057qib7 12768 1 50000 50000 CD cord-005453-4057qib7 12768 2 platelets platelet NNS cord-005453-4057qib7 12768 3 / / SYM cord-005453-4057qib7 12768 4 mm3 mm3 NNS cord-005453-4057qib7 12768 5 ( ( -LRB- cord-005453-4057qib7 12768 6 median median NN cord-005453-4057qib7 12768 7 : : : cord-005453-4057qib7 12768 8 13 13 CD cord-005453-4057qib7 12768 9 vs vs IN cord-005453-4057qib7 12768 10 16 16 CD cord-005453-4057qib7 12768 11 days day NNS cord-005453-4057qib7 12768 12 , , , cord-005453-4057qib7 12768 13 P p NN cord-005453-4057qib7 12768 14 0.09 0.09 CD cord-005453-4057qib7 12768 15 ) ) -RRB- cord-005453-4057qib7 12768 16 ; ; : cord-005453-4057qib7 12768 17 > > XX cord-005453-4057qib7 12769 1 500 500 CD cord-005453-4057qib7 12769 2 neutrophils neutrophil NNS cord-005453-4057qib7 12769 3 / / SYM cord-005453-4057qib7 12769 4 mm3 mm3 NNS cord-005453-4057qib7 12769 5 ( ( -LRB- cord-005453-4057qib7 12769 6 median median NN cord-005453-4057qib7 12769 7 : : : cord-005453-4057qib7 12769 8 13 13 CD cord-005453-4057qib7 12769 9 vs vs IN cord-005453-4057qib7 12769 10 13.5 13.5 CD cord-005453-4057qib7 12769 11 days day NNS cord-005453-4057qib7 12769 12 , , , cord-005453-4057qib7 12769 13 P p NN cord-005453-4057qib7 12769 14 0.3 0.3 CD cord-005453-4057qib7 12769 15 ) ) -RRB- cord-005453-4057qib7 12769 16 . . . cord-005453-4057qib7 12770 1 The the DT cord-005453-4057qib7 12770 2 media medium NNS cord-005453-4057qib7 12770 3 of of IN cord-005453-4057qib7 12770 4 days day NNS cord-005453-4057qib7 12770 5 of of IN cord-005453-4057qib7 12770 6 hospitalization hospitalization NN cord-005453-4057qib7 12770 7 was be VBD cord-005453-4057qib7 12770 8 shorter short JJR cord-005453-4057qib7 12770 9 in in IN cord-005453-4057qib7 12770 10 non non JJ cord-005453-4057qib7 12770 11 - - JJ cord-005453-4057qib7 12770 12 cryopreserved cryopreserved JJ cord-005453-4057qib7 12770 13 patients patient NNS cord-005453-4057qib7 12770 14 ( ( -LRB- cord-005453-4057qib7 12770 15 18 18 CD cord-005453-4057qib7 12770 16 vs vs IN cord-005453-4057qib7 12770 17 21 21 CD cord-005453-4057qib7 12770 18 days day NNS cord-005453-4057qib7 12770 19 ) ) -RRB- cord-005453-4057qib7 12770 20 although although IN cord-005453-4057qib7 12770 21 not not RB cord-005453-4057qib7 12770 22 statistically statistically RB cord-005453-4057qib7 12770 23 significant significant JJ cord-005453-4057qib7 12770 24 ( ( -LRB- cord-005453-4057qib7 12770 25 P p NN cord-005453-4057qib7 12770 26 0.14 0.14 CD cord-005453-4057qib7 12770 27 ) ) -RRB- cord-005453-4057qib7 12770 28 . . . cord-005453-4057qib7 12771 1 Transplantrelated transplantrelate VBN cord-005453-4057qib7 12771 2 mortality mortality NN cord-005453-4057qib7 12771 3 at at IN cord-005453-4057qib7 12771 4 day day NN cord-005453-4057qib7 12772 1 +100 +100 NNP cord-005453-4057qib7 12772 2 was be VBD cord-005453-4057qib7 12772 3 0 0 CD cord-005453-4057qib7 12772 4 % % NN cord-005453-4057qib7 12772 5 in in IN cord-005453-4057qib7 12772 6 both both DT cord-005453-4057qib7 12772 7 groups group NNS cord-005453-4057qib7 12772 8 . . . cord-005453-4057qib7 12773 1 Overall overall JJ cord-005453-4057qib7 12773 2 survival survival NN cord-005453-4057qib7 12773 3 at at IN cord-005453-4057qib7 12773 4 5 5 CD cord-005453-4057qib7 12773 5 years year NNS cord-005453-4057qib7 12773 6 was be VBD cord-005453-4057qib7 12773 7 not not RB cord-005453-4057qib7 12773 8 different different JJ cord-005453-4057qib7 12773 9 : : : cord-005453-4057qib7 12773 10 83.3 83.3 CD cord-005453-4057qib7 12773 11 % % NN cord-005453-4057qib7 12773 12 in in IN cord-005453-4057qib7 12773 13 in in IN cord-005453-4057qib7 12773 14 non non JJ cord-005453-4057qib7 12773 15 - - JJ cord-005453-4057qib7 12773 16 cryopreserved cryopreserved JJ cord-005453-4057qib7 12773 17 vs vs IN cord-005453-4057qib7 12773 18 61.5 61.5 CD cord-005453-4057qib7 12773 19 % % NN cord-005453-4057qib7 12773 20 in in IN cord-005453-4057qib7 12773 21 cryopreserved cryopreserved JJ cord-005453-4057qib7 12773 22 patients patient NNS cord-005453-4057qib7 12773 23 ( ( -LRB- cord-005453-4057qib7 12773 24 Kaplan Kaplan NNP cord-005453-4057qib7 12773 25 - - HYPH cord-005453-4057qib7 12773 26 Meier Meier NNP cord-005453-4057qib7 12773 27 , , , cord-005453-4057qib7 12773 28 Log Log NNP cord-005453-4057qib7 12773 29 - - HYPH cord-005453-4057qib7 12773 30 rank rank NN cord-005453-4057qib7 12773 31 P p NN cord-005453-4057qib7 12773 32 0.27 0.27 CD cord-005453-4057qib7 12773 33 ) ) -RRB- cord-005453-4057qib7 12773 34 . . . cord-005453-4057qib7 12774 1 The the DT cord-005453-4057qib7 12774 2 accumulative accumulative JJ cord-005453-4057qib7 12774 3 incidence incidence NN cord-005453-4057qib7 12774 4 of of IN cord-005453-4057qib7 12774 5 relapse relapse NN cord-005453-4057qib7 12774 6 at at IN cord-005453-4057qib7 12774 7 the the DT cord-005453-4057qib7 12774 8 median median NN cord-005453-4057qib7 12774 9 follow follow VBP cord-005453-4057qib7 12774 10 up up RP cord-005453-4057qib7 12774 11 ( ( -LRB- cord-005453-4057qib7 12774 12 1600 1600 CD cord-005453-4057qib7 12774 13 days day NNS cord-005453-4057qib7 12774 14 ) ) -RRB- cord-005453-4057qib7 12774 15 was be VBD cord-005453-4057qib7 12774 16 similar similar JJ cord-005453-4057qib7 12774 17 : : : cord-005453-4057qib7 12774 18 33.3 33.3 CD cord-005453-4057qib7 12774 19 % % NN cord-005453-4057qib7 12774 20 in in IN cord-005453-4057qib7 12774 21 non non JJ cord-005453-4057qib7 12774 22 - - JJ cord-005453-4057qib7 12774 23 cryopreserved cryopreserved JJ cord-005453-4057qib7 12774 24 vs vs IN cord-005453-4057qib7 12774 25 35.9 35.9 CD cord-005453-4057qib7 12774 26 % % NN cord-005453-4057qib7 12774 27 in in IN cord-005453-4057qib7 12774 28 cryopreserved cryopreserved JJ cord-005453-4057qib7 12774 29 patients patient NNS cord-005453-4057qib7 12774 30 . . . cord-005453-4057qib7 12775 1 Conclusions conclusion NNS cord-005453-4057qib7 12775 2 : : : cord-005453-4057qib7 12776 1 In in IN cord-005453-4057qib7 12776 2 our -PRON- PRP$ cord-005453-4057qib7 12776 3 short short JJ cord-005453-4057qib7 12776 4 experience experience NN cord-005453-4057qib7 12776 5 , , , cord-005453-4057qib7 12776 6 auto auto NN cord-005453-4057qib7 12776 7 - - HYPH cord-005453-4057qib7 12776 8 HSCT HSCT NNP cord-005453-4057qib7 12776 9 with with IN cord-005453-4057qib7 12776 10 non non JJ cord-005453-4057qib7 12776 11 - - JJ cord-005453-4057qib7 12776 12 cryopreserved cryopreserved JJ cord-005453-4057qib7 12776 13 PBPC PBPC NNP cord-005453-4057qib7 12776 14 in in IN cord-005453-4057qib7 12776 15 myeloma myeloma NN cord-005453-4057qib7 12776 16 patients patient NNS cord-005453-4057qib7 12776 17 conditioned condition VBN cord-005453-4057qib7 12776 18 with with IN cord-005453-4057qib7 12776 19 high high JJ cord-005453-4057qib7 12776 20 dose dose NN cord-005453-4057qib7 12776 21 melphalan melphalan NNP cord-005453-4057qib7 12776 22 obtain obtain VBP cord-005453-4057qib7 12776 23 similar similar JJ cord-005453-4057qib7 12776 24 results result NNS cord-005453-4057qib7 12776 25 to to IN cord-005453-4057qib7 12776 26 those those DT cord-005453-4057qib7 12776 27 performed perform VBN cord-005453-4057qib7 12776 28 with with IN cord-005453-4057qib7 12776 29 classical classical JJ cord-005453-4057qib7 12776 30 cryopreserved cryopreserved JJ cord-005453-4057qib7 12776 31 PBPC PBPC NNP cord-005453-4057qib7 12776 32 and and CC cord-005453-4057qib7 12776 33 might may MD cord-005453-4057qib7 12776 34 has have VBZ cord-005453-4057qib7 12776 35 a a DT cord-005453-4057qib7 12776 36 faster fast JJR cord-005453-4057qib7 12776 37 platelet platelet NN cord-005453-4057qib7 12776 38 engraftment engraftment NN cord-005453-4057qib7 12776 39 and and CC cord-005453-4057qib7 12776 40 shorter short JJR cord-005453-4057qib7 12776 41 length length NN cord-005453-4057qib7 12776 42 of of IN cord-005453-4057qib7 12776 43 hospitalization hospitalization NN cord-005453-4057qib7 12776 44 . . . cord-005453-4057qib7 12777 1 If if IN cord-005453-4057qib7 12777 2 no no DT cord-005453-4057qib7 12777 3 advantages advantage NNS cord-005453-4057qib7 12777 4 are be VBP cord-005453-4057qib7 12777 5 associated associate VBN cord-005453-4057qib7 12777 6 with with IN cord-005453-4057qib7 12777 7 cryopreservation cryopreservation NN cord-005453-4057qib7 12777 8 , , , cord-005453-4057qib7 12777 9 the the DT cord-005453-4057qib7 12777 10 simplicity simplicity NN cord-005453-4057qib7 12777 11 of of IN cord-005453-4057qib7 12777 12 using use VBG cord-005453-4057qib7 12777 13 fresh fresh JJ cord-005453-4057qib7 12777 14 product product NN cord-005453-4057qib7 12777 15 is be VBZ cord-005453-4057qib7 12777 16 appealing appeal VBG cord-005453-4057qib7 12777 17 . . . cord-005453-4057qib7 12778 1 Disclosure disclosure NN cord-005453-4057qib7 12778 2 : : : cord-005453-4057qib7 12778 3 Nothing nothing NN cord-005453-4057qib7 12778 4 to to TO cord-005453-4057qib7 12778 5 declare declare VB cord-005453-4057qib7 12778 6 P565 P565 NNP cord-005453-4057qib7 12778 7 Abstract Abstract NNP cord-005453-4057qib7 12778 8 withdrawn withdraw VBN cord-005453-4057qib7 12778 9 . . . cord-005453-4057qib7 12778 10 . . . cord-005453-4057qib7 12779 1 Results result NNS cord-005453-4057qib7 12779 2 : : : cord-005453-4057qib7 12780 1 A a DT cord-005453-4057qib7 12780 2 early early JJ cord-005453-4057qib7 12780 3 death death NN cord-005453-4057qib7 12780 4 is be VBZ cord-005453-4057qib7 12780 5 observed observe VBN cord-005453-4057qib7 12780 6 in in IN cord-005453-4057qib7 12780 7 one one CD cord-005453-4057qib7 12780 8 pt pt NN cord-005453-4057qib7 12780 9 ( ( -LRB- cord-005453-4057qib7 12780 10 Group Group NNP cord-005453-4057qib7 12780 11 1 1 CD cord-005453-4057qib7 12780 12 ) ) -RRB- cord-005453-4057qib7 12780 13 and and CC cord-005453-4057qib7 12780 14 5 5 CD cord-005453-4057qib7 12780 15 pts(Group pts(group NN cord-005453-4057qib7 12780 16 2 2 CD cord-005453-4057qib7 12780 17 ) ) -RRB- cord-005453-4057qib7 12780 18 . . . cord-005453-4057qib7 12781 1 The the DT cord-005453-4057qib7 12781 2 median median JJ cord-005453-4057qib7 12781 3 delay delay NN cord-005453-4057qib7 12781 4 of of IN cord-005453-4057qib7 12781 5 aplasia aplasia NNP cord-005453-4057qib7 12781 6 is be VBZ cord-005453-4057qib7 12781 7 14 14 CD cord-005453-4057qib7 12781 8 days day NNS cord-005453-4057qib7 12781 9 ( ( -LRB- cord-005453-4057qib7 12781 10 10 10 CD cord-005453-4057qib7 12781 11 - - SYM cord-005453-4057qib7 12781 12 22 22 CD cord-005453-4057qib7 12781 13 ) ) -RRB- cord-005453-4057qib7 12781 14 and and CC cord-005453-4057qib7 12781 15 12 12 CD cord-005453-4057qib7 12781 16 days day NNS cord-005453-4057qib7 12781 17 ( ( -LRB- cord-005453-4057qib7 12781 18 9 9 CD cord-005453-4057qib7 12781 19 - - SYM cord-005453-4057qib7 12781 20 17 17 CD cord-005453-4057qib7 12781 21 ) ) -RRB- cord-005453-4057qib7 12781 22 respectively respectively RB cord-005453-4057qib7 12781 23 . . . cord-005453-4057qib7 12782 1 In in IN cord-005453-4057qib7 12782 2 group group NN cord-005453-4057qib7 12782 3 1 1 CD cord-005453-4057qib7 12782 4 , , , cord-005453-4057qib7 12782 5 among among IN cord-005453-4057qib7 12782 6 the the DT cord-005453-4057qib7 12782 7 evaluable evaluable JJ cord-005453-4057qib7 12782 8 pts pt NNS cord-005453-4057qib7 12782 9 , , , cord-005453-4057qib7 12782 10 30/37 30/37 CD cord-005453-4057qib7 12782 11 ( ( -LRB- cord-005453-4057qib7 12782 12 81 81 CD cord-005453-4057qib7 12782 13 % % NN cord-005453-4057qib7 12782 14 ) ) -RRB- cord-005453-4057qib7 12782 15 are be VBP cord-005453-4057qib7 12782 16 in in IN cord-005453-4057qib7 12782 17 CR CR NNP cord-005453-4057qib7 12782 18 , , , cord-005453-4057qib7 12782 19 5 5 CD cord-005453-4057qib7 12782 20 pts pt NNS cord-005453-4057qib7 12782 21 in in IN cord-005453-4057qib7 12782 22 PR PR NNP cord-005453-4057qib7 12782 23 and and CC cord-005453-4057qib7 12782 24 2 2 CD cord-005453-4057qib7 12782 25 refractory refractory NN cord-005453-4057qib7 12782 26 . . . cord-005453-4057qib7 12783 1 In in IN cord-005453-4057qib7 12783 2 Group Group NNP cord-005453-4057qib7 12783 3 2 2 CD cord-005453-4057qib7 12783 4 , , , cord-005453-4057qib7 12783 5 CR CR NNP cord-005453-4057qib7 12783 6 : : : cord-005453-4057qib7 12783 7 35/43 35/43 CD cord-005453-4057qib7 12783 8 ( ( -LRB- cord-005453-4057qib7 12783 9 81 81 CD cord-005453-4057qib7 12783 10 % % NN cord-005453-4057qib7 12783 11 ) ) -RRB- cord-005453-4057qib7 12783 12 , , , cord-005453-4057qib7 12783 13 PR PR NNP cord-005453-4057qib7 12783 14 : : : cord-005453-4057qib7 12783 15 6 6 CD cord-005453-4057qib7 12783 16 and and CC cord-005453-4057qib7 12783 17 2 2 CD cord-005453-4057qib7 12783 18 refractory refractory NN cord-005453-4057qib7 12783 19 . . . cord-005453-4057qib7 12784 1 A a DT cord-005453-4057qib7 12784 2 relapse relapse NN cord-005453-4057qib7 12784 3 is be VBZ cord-005453-4057qib7 12784 4 observed observe VBN cord-005453-4057qib7 12784 5 in in IN cord-005453-4057qib7 12784 6 32 32 CD cord-005453-4057qib7 12784 7 pts/37 pts/37 NN cord-005453-4057qib7 12784 8 ( ( -LRB- cord-005453-4057qib7 12784 9 86,5 86,5 CD cord-005453-4057qib7 12784 10 % % NN cord-005453-4057qib7 12784 11 ) ) -RRB- cord-005453-4057qib7 12784 12 in in IN cord-005453-4057qib7 12784 13 Group Group NNP cord-005453-4057qib7 12784 14 1 1 CD cord-005453-4057qib7 12784 15 and and CC cord-005453-4057qib7 12784 16 35 35 CD cord-005453-4057qib7 12784 17 pts/43 pts/43 NNP cord-005453-4057qib7 12784 18 ( ( -LRB- cord-005453-4057qib7 12784 19 81 81 CD cord-005453-4057qib7 12784 20 % % NN cord-005453-4057qib7 12784 21 ) ) -RRB- cord-005453-4057qib7 12784 22 in in IN cord-005453-4057qib7 12784 23 Group Group NNP cord-005453-4057qib7 12784 24 2 2 CD cord-005453-4057qib7 12784 25 with with IN cord-005453-4057qib7 12784 26 a a DT cord-005453-4057qib7 12784 27 frequency frequency NN cord-005453-4057qib7 12784 28 of of IN cord-005453-4057qib7 12784 29 54 54 CD cord-005453-4057qib7 12784 30 % % NN cord-005453-4057qib7 12784 31 and and CC cord-005453-4057qib7 12784 32 41 41 CD cord-005453-4057qib7 12784 33 % % NN cord-005453-4057qib7 12784 34 respectively respectively RB cord-005453-4057qib7 12784 35 in in IN cord-005453-4057qib7 12784 36 the the DT cord-005453-4057qib7 12784 37 first first JJ cord-005453-4057qib7 12784 38 24 24 CD cord-005453-4057qib7 12784 39 months month NNS cord-005453-4057qib7 12784 40 . . . cord-005453-4057qib7 12785 1 At at IN cord-005453-4057qib7 12785 2 36 36 CD cord-005453-4057qib7 12785 3 months month NNS cord-005453-4057qib7 12785 4 : : : cord-005453-4057qib7 12785 5 13 13 CD cord-005453-4057qib7 12785 6 pts/38 pts/38 NNP cord-005453-4057qib7 12785 7 ( ( -LRB- cord-005453-4057qib7 12785 8 34 34 CD cord-005453-4057qib7 12785 9 % % NN cord-005453-4057qib7 12785 10 ) ) -RRB- cord-005453-4057qib7 12785 11 in in IN cord-005453-4057qib7 12785 12 Group Group NNP cord-005453-4057qib7 12785 13 1 1 CD cord-005453-4057qib7 12785 14 and and CC cord-005453-4057qib7 12785 15 19 19 CD cord-005453-4057qib7 12785 16 pts/49 pts/49 NNP cord-005453-4057qib7 12785 17 ( ( -LRB- cord-005453-4057qib7 12785 18 38 38 CD cord-005453-4057qib7 12785 19 % % NN cord-005453-4057qib7 12785 20 ) ) -RRB- cord-005453-4057qib7 12785 21 in in IN cord-005453-4057qib7 12785 22 Group Group NNP cord-005453-4057qib7 12785 23 2 2 CD cord-005453-4057qib7 12785 24 are be VBP cord-005453-4057qib7 12785 25 dead dead JJ cord-005453-4057qib7 12785 26 . . . cord-005453-4057qib7 12786 1 At at IN cord-005453-4057qib7 12786 2 60 60 CD cord-005453-4057qib7 12786 3 months month NNS cord-005453-4057qib7 12786 4 : : : cord-005453-4057qib7 12786 5 20 20 CD cord-005453-4057qib7 12786 6 pts pt NNS cord-005453-4057qib7 12786 7 ( ( -LRB- cord-005453-4057qib7 12786 8 52 52 CD cord-005453-4057qib7 12786 9 % % NN cord-005453-4057qib7 12786 10 ) ) -RRB- cord-005453-4057qib7 12786 11 and and CC cord-005453-4057qib7 12786 12 29 29 CD cord-005453-4057qib7 12786 13 pts pt NNS cord-005453-4057qib7 12786 14 ( ( -LRB- cord-005453-4057qib7 12786 15 59 59 CD cord-005453-4057qib7 12786 16 % % NN cord-005453-4057qib7 12786 17 ) ) -RRB- cord-005453-4057qib7 12786 18 . . . cord-005453-4057qib7 12787 1 At at IN cord-005453-4057qib7 12787 2 120 120 CD cord-005453-4057qib7 12787 3 months month NNS cord-005453-4057qib7 12787 4 : : : cord-005453-4057qib7 12787 5 31 31 CD cord-005453-4057qib7 12787 6 pts pt NNS cord-005453-4057qib7 12787 7 ( ( -LRB- cord-005453-4057qib7 12787 8 81,5 81,5 CD cord-005453-4057qib7 12787 9 % % NN cord-005453-4057qib7 12787 10 ) ) -RRB- cord-005453-4057qib7 12787 11 and and CC cord-005453-4057qib7 12787 12 37 37 CD cord-005453-4057qib7 12787 13 pts pt NNS cord-005453-4057qib7 12787 14 ( ( -LRB- cord-005453-4057qib7 12787 15 75,5 75,5 CD cord-005453-4057qib7 12787 16 % % NN cord-005453-4057qib7 12787 17 ) ) -RRB- cord-005453-4057qib7 12787 18 . . . cord-005453-4057qib7 12788 1 The the DT cord-005453-4057qib7 12788 2 overall overall JJ cord-005453-4057qib7 12788 3 survival survival NN cord-005453-4057qib7 12788 4 ( ( -LRB- cord-005453-4057qib7 12788 5 OS OS NNP cord-005453-4057qib7 12788 6 ) ) -RRB- cord-005453-4057qib7 12788 7 of of IN cord-005453-4057qib7 12788 8 the the DT cord-005453-4057qib7 12788 9 Group Group NNP cord-005453-4057qib7 12788 10 1 1 CD cord-005453-4057qib7 12788 11 and and CC cord-005453-4057qib7 12788 12 Group Group NNP cord-005453-4057qib7 12788 13 2 2 CD cord-005453-4057qib7 12788 14 pts pt NNS cord-005453-4057qib7 12788 15 were be VBD cord-005453-4057qib7 12788 16 66 66 CD cord-005453-4057qib7 12788 17 % % NN cord-005453-4057qib7 12788 18 and and CC cord-005453-4057qib7 12788 19 62 62 CD cord-005453-4057qib7 12788 20 % % NN cord-005453-4057qib7 12788 21 at at IN cord-005453-4057qib7 12788 22 36 36 CD cord-005453-4057qib7 12788 23 months month NNS cord-005453-4057qib7 12788 24 ; ; : cord-005453-4057qib7 12788 25 47.5 47.5 CD cord-005453-4057qib7 12788 26 % % NN cord-005453-4057qib7 12788 27 and and CC cord-005453-4057qib7 12788 28 38.5 38.5 CD cord-005453-4057qib7 12788 29 % % NN cord-005453-4057qib7 12788 30 at at IN cord-005453-4057qib7 12788 31 60 60 CD cord-005453-4057qib7 12788 32 months month NNS cord-005453-4057qib7 12788 33 ; ; : cord-005453-4057qib7 12788 34 18 18 CD cord-005453-4057qib7 12788 35 % % NN cord-005453-4057qib7 12788 36 and and CC cord-005453-4057qib7 12788 37 24,5 24,5 CD cord-005453-4057qib7 12788 38 % % NN cord-005453-4057qib7 12788 39 at at IN cord-005453-4057qib7 12788 40 120 120 CD cord-005453-4057qib7 12788 41 months month NNS cord-005453-4057qib7 12788 42 respectively respectively RB cord-005453-4057qib7 12788 43 ( ( -LRB- cord-005453-4057qib7 12788 44 without without IN cord-005453-4057qib7 12788 45 significant significant JJ cord-005453-4057qib7 12788 46 difference difference NN cord-005453-4057qib7 12788 47 ) ) -RRB- cord-005453-4057qib7 12788 48 . . . cord-005453-4057qib7 12789 1 The the DT cord-005453-4057qib7 12789 2 event event NN cord-005453-4057qib7 12789 3 free free JJ cord-005453-4057qib7 12789 4 survival survival NN cord-005453-4057qib7 12789 5 ( ( -LRB- cord-005453-4057qib7 12789 6 EFS EFS NNP cord-005453-4057qib7 12789 7 ) ) -RRB- cord-005453-4057qib7 12789 8 of of IN cord-005453-4057qib7 12789 9 group group NN cord-005453-4057qib7 12789 10 1 1 CD cord-005453-4057qib7 12789 11 and and CC cord-005453-4057qib7 12789 12 2 2 CD cord-005453-4057qib7 12789 13 pts pt NNS cord-005453-4057qib7 12789 14 were be VBD cord-005453-4057qib7 12789 15 37 37 CD cord-005453-4057qib7 12789 16 % % NN cord-005453-4057qib7 12789 17 and and CC cord-005453-4057qib7 12789 18 36,5 36,5 CD cord-005453-4057qib7 12789 19 % % NN cord-005453-4057qib7 12789 20 at at IN cord-005453-4057qib7 12789 21 36 36 CD cord-005453-4057qib7 12789 22 months month NNS cord-005453-4057qib7 12789 23 , , , cord-005453-4057qib7 12789 24 25 25 CD cord-005453-4057qib7 12789 25 % % NN cord-005453-4057qib7 12789 26 and and CC cord-005453-4057qib7 12789 27 13 13 CD cord-005453-4057qib7 12789 28 % % NN cord-005453-4057qib7 12789 29 at at IN cord-005453-4057qib7 12789 30 60 60 CD cord-005453-4057qib7 12789 31 months month NNS cord-005453-4057qib7 12789 32 and and CC cord-005453-4057qib7 12789 33 8 8 CD cord-005453-4057qib7 12789 34 % % NN cord-005453-4057qib7 12789 35 and and CC cord-005453-4057qib7 12789 36 15 15 CD cord-005453-4057qib7 12789 37 % % NN cord-005453-4057qib7 12789 38 at at IN cord-005453-4057qib7 12789 39 120 120 CD cord-005453-4057qib7 12789 40 months month NNS cord-005453-4057qib7 12789 41 respectively respectively RB cord-005453-4057qib7 12789 42 ( ( -LRB- cord-005453-4057qib7 12789 43 without without IN cord-005453-4057qib7 12789 44 significant significant JJ cord-005453-4057qib7 12789 45 difference difference NN cord-005453-4057qib7 12789 46 ) ) -RRB- cord-005453-4057qib7 12789 47 . . . cord-005453-4057qib7 12790 1 Conclusions conclusion NNS cord-005453-4057qib7 12790 2 : : : cord-005453-4057qib7 12791 1 These these DT cord-005453-4057qib7 12791 2 2 2 CD cord-005453-4057qib7 12791 3 protocols protocol NNS cord-005453-4057qib7 12791 4 with with IN cord-005453-4057qib7 12791 5 equivalent equivalent JJ cord-005453-4057qib7 12791 6 toxicity toxicity NN cord-005453-4057qib7 12791 7 allow allow VBP cord-005453-4057qib7 12791 8 obtaining obtaining NN cord-005453-4057qib7 12791 9 of of IN cord-005453-4057qib7 12791 10 long long JJ cord-005453-4057qib7 12791 11 - - HYPH cord-005453-4057qib7 12791 12 term term NN cord-005453-4057qib7 12791 13 equivalent equivalent JJ cord-005453-4057qib7 12791 14 results result NNS cord-005453-4057qib7 12791 15 on on IN cord-005453-4057qib7 12791 16 the the DT cord-005453-4057qib7 12791 17 response response NN cord-005453-4057qib7 12791 18 rate rate NN cord-005453-4057qib7 12791 19 early early JJ cord-005453-4057qib7 12791 20 transplant transplant NN cord-005453-4057qib7 12791 21 , , , cord-005453-4057qib7 12791 22 on on IN cord-005453-4057qib7 12791 23 the the DT cord-005453-4057qib7 12791 24 rate rate NN cord-005453-4057qib7 12791 25 of of IN cord-005453-4057qib7 12791 26 relapse relapse NN cord-005453-4057qib7 12791 27 and and CC cord-005453-4057qib7 12791 28 on on IN cord-005453-4057qib7 12791 29 the the DT cord-005453-4057qib7 12791 30 overall overall JJ cord-005453-4057qib7 12791 31 survival survival NN cord-005453-4057qib7 12791 32 . . . cord-005453-4057qib7 12792 1 These these DT cord-005453-4057qib7 12792 2 results result NNS cord-005453-4057qib7 12792 3 are be VBP cord-005453-4057qib7 12792 4 identical identical JJ cord-005453-4057qib7 12792 5 to to IN cord-005453-4057qib7 12792 6 those those DT cord-005453-4057qib7 12792 7 of of IN cord-005453-4057qib7 12792 8 Fermand Fermand NNP cord-005453-4057qib7 12792 9 ( ( -LRB- cord-005453-4057qib7 12792 10 1999 1999 CD cord-005453-4057qib7 12792 11 ) ) -RRB- cord-005453-4057qib7 12792 12 . . . cord-005453-4057qib7 12793 1 Disclosure disclosure NN cord-005453-4057qib7 12793 2 : : : cord-005453-4057qib7 12793 3 Nothing nothing NN cord-005453-4057qib7 12793 4 to to TO cord-005453-4057qib7 12793 5 declare declare VB cord-005453-4057qib7 12793 6 Background background NN cord-005453-4057qib7 12793 7 : : : cord-005453-4057qib7 12793 8 Dimethylsulfoxide Dimethylsulfoxide NNP cord-005453-4057qib7 12793 9 ( ( -LRB- cord-005453-4057qib7 12793 10 DMSO DMSO NNP cord-005453-4057qib7 12793 11 ) ) -RRB- cord-005453-4057qib7 12793 12 is be VBZ cord-005453-4057qib7 12793 13 a a DT cord-005453-4057qib7 12793 14 major major JJ cord-005453-4057qib7 12793 15 intracellular intracellular JJ cord-005453-4057qib7 12793 16 cryoprotectant cryoprotectant NN cord-005453-4057qib7 12793 17 , , , cord-005453-4057qib7 12793 18 used use VBN cord-005453-4057qib7 12793 19 for for IN cord-005453-4057qib7 12793 20 cryopreservation cryopreservation NN cord-005453-4057qib7 12793 21 of of IN cord-005453-4057qib7 12793 22 stem stem NN cord-005453-4057qib7 12793 23 cells cell NNS cord-005453-4057qib7 12793 24 . . . cord-005453-4057qib7 12794 1 It -PRON- PRP cord-005453-4057qib7 12794 2 is be VBZ cord-005453-4057qib7 12794 3 toxic toxic JJ cord-005453-4057qib7 12794 4 to to IN cord-005453-4057qib7 12794 5 both both DT cord-005453-4057qib7 12794 6 cells cell NNS cord-005453-4057qib7 12794 7 and and CC cord-005453-4057qib7 12794 8 patients patient NNS cord-005453-4057qib7 12794 9 at at IN cord-005453-4057qib7 12794 10 temperatures temperature NNS cord-005453-4057qib7 12794 11 above above IN cord-005453-4057qib7 12794 12 0 0 CD cord-005453-4057qib7 12794 13 o o NN cord-005453-4057qib7 12794 14 C. C. NNP cord-005453-4057qib7 12794 15 Reduction reduction NN cord-005453-4057qib7 12794 16 of of IN cord-005453-4057qib7 12794 17 this this DT cord-005453-4057qib7 12794 18 effect effect NN cord-005453-4057qib7 12794 19 is be VBZ cord-005453-4057qib7 12794 20 achieved achieve VBN cord-005453-4057qib7 12794 21 by by IN cord-005453-4057qib7 12794 22 either either DT cord-005453-4057qib7 12794 23 washing washing NN cord-005453-4057qib7 12794 24 of of IN cord-005453-4057qib7 12794 25 cells cell NNS cord-005453-4057qib7 12794 26 after after IN cord-005453-4057qib7 12794 27 thawing thaw VBG cord-005453-4057qib7 12794 28 or or CC cord-005453-4057qib7 12794 29 by by IN cord-005453-4057qib7 12794 30 reduction reduction NN cord-005453-4057qib7 12794 31 of of IN cord-005453-4057qib7 12794 32 DMSO DMSO NNP cord-005453-4057qib7 12794 33 during during IN cord-005453-4057qib7 12794 34 freezing freezing NN cord-005453-4057qib7 12794 35 and and CC cord-005453-4057qib7 12794 36 storage storage NN cord-005453-4057qib7 12794 37 . . . cord-005453-4057qib7 12795 1 The the DT cord-005453-4057qib7 12795 2 latter latter JJ cord-005453-4057qib7 12795 3 requires require VBZ cord-005453-4057qib7 12795 4 addition addition NN cord-005453-4057qib7 12795 5 of of IN cord-005453-4057qib7 12795 6 extracellular extracellular JJ cord-005453-4057qib7 12795 7 cryoprotectants cryoprotectant NNS cord-005453-4057qib7 12795 8 to to IN cord-005453-4057qib7 12795 9 the the DT cord-005453-4057qib7 12795 10 freezing freeze VBG cord-005453-4057qib7 12795 11 media medium NNS cord-005453-4057qib7 12795 12 . . . cord-005453-4057qib7 12796 1 We -PRON- PRP cord-005453-4057qib7 12796 2 assessed assess VBD cord-005453-4057qib7 12796 3 the the DT cord-005453-4057qib7 12796 4 effect effect NN cord-005453-4057qib7 12796 5 of of IN cord-005453-4057qib7 12796 6 low low JJ cord-005453-4057qib7 12796 7 DMSO DMSO NNP cord-005453-4057qib7 12796 8 concentration concentration NN cord-005453-4057qib7 12796 9 and and CC cord-005453-4057qib7 12796 10 different different JJ cord-005453-4057qib7 12796 11 hematocrits hematocrit NNS cord-005453-4057qib7 12796 12 of of IN cord-005453-4057qib7 12796 13 the the DT cord-005453-4057qib7 12796 14 frozen frozen JJ cord-005453-4057qib7 12796 15 cells cell NNS cord-005453-4057qib7 12796 16 on on IN cord-005453-4057qib7 12796 17 cell cell NN cord-005453-4057qib7 12796 18 viability viability NN cord-005453-4057qib7 12796 19 and and CC cord-005453-4057qib7 12796 20 hematologic hematologic JJ cord-005453-4057qib7 12796 21 recovery recovery NN cord-005453-4057qib7 12796 22 in in IN cord-005453-4057qib7 12796 23 patients patient NNS cord-005453-4057qib7 12796 24 , , , cord-005453-4057qib7 12796 25 transplanted transplant VBN cord-005453-4057qib7 12796 26 for for IN cord-005453-4057qib7 12796 27 multiple multiple JJ cord-005453-4057qib7 12796 28 myeloma myeloma NN cord-005453-4057qib7 12796 29 . . . cord-005453-4057qib7 12797 1 Methods method NNS cord-005453-4057qib7 12797 2 : : : cord-005453-4057qib7 12798 1 Cells cell NNS cord-005453-4057qib7 12798 2 were be VBD cord-005453-4057qib7 12798 3 non non JJ cord-005453-4057qib7 12798 4 - - JJ cord-005453-4057qib7 12798 5 programmed program VBN cord-005453-4057qib7 12798 6 frozen frozen JJ cord-005453-4057qib7 12798 7 and and CC cord-005453-4057qib7 12798 8 stored store VBN cord-005453-4057qib7 12798 9 at at IN cord-005453-4057qib7 12798 10 -80 -80 NNP cord-005453-4057qib7 12798 11 o o NN cord-005453-4057qib7 12798 12 C c NN cord-005453-4057qib7 12798 13 in in IN cord-005453-4057qib7 12798 14 a a DT cord-005453-4057qib7 12798 15 cryoprotectant cryoprotectant NN cord-005453-4057qib7 12798 16 solution solution NN cord-005453-4057qib7 12798 17 achieving achieve VBG cord-005453-4057qib7 12798 18 final final JJ cord-005453-4057qib7 12798 19 concentrations concentration NNS cord-005453-4057qib7 12798 20 of of IN cord-005453-4057qib7 12798 21 5 5 CD cord-005453-4057qib7 12798 22 % % NN cord-005453-4057qib7 12798 23 DMSO DMSO NNP cord-005453-4057qib7 12798 24 , , , cord-005453-4057qib7 12798 25 3.6 3.6 CD cord-005453-4057qib7 12798 26 % % NN cord-005453-4057qib7 12798 27 of of IN cord-005453-4057qib7 12798 28 hydroxyethyl hydroxyethyl NN cord-005453-4057qib7 12798 29 starch starch NN cord-005453-4057qib7 12798 30 ( ( -LRB- cord-005453-4057qib7 12798 31 HES hes UH cord-005453-4057qib7 12798 32 , , , cord-005453-4057qib7 12798 33 Weight weight NN cord-005453-4057qib7 12798 34 average average JJ cord-005453-4057qib7 12798 35 molecular molecular JJ cord-005453-4057qib7 12798 36 weight weight NN cord-005453-4057qib7 12798 37 450 450 CD cord-005453-4057qib7 12798 38 000 000 CD cord-005453-4057qib7 12798 39 Da Da NNP cord-005453-4057qib7 12798 40 ) ) -RRB- cord-005453-4057qib7 12798 41 and and CC cord-005453-4057qib7 12798 42 3 3 CD cord-005453-4057qib7 12798 43 % % NN cord-005453-4057qib7 12798 44 of of IN cord-005453-4057qib7 12798 45 human human JJ cord-005453-4057qib7 12798 46 serum serum NN cord-005453-4057qib7 12798 47 albumin albumin NN cord-005453-4057qib7 12798 48 . . . cord-005453-4057qib7 12799 1 The the DT cord-005453-4057qib7 12799 2 cell cell NN cord-005453-4057qib7 12799 3 concentration concentration NN cord-005453-4057qib7 12799 4 in in IN cord-005453-4057qib7 12799 5 the the DT cord-005453-4057qib7 12799 6 frozen frozen JJ cord-005453-4057qib7 12799 7 product product NN cord-005453-4057qib7 12799 8 for for IN cord-005453-4057qib7 12799 9 the the DT cord-005453-4057qib7 12799 10 first first JJ cord-005453-4057qib7 12799 11 77 77 CD cord-005453-4057qib7 12799 12 patients patient NNS cord-005453-4057qib7 12799 13 ( ( -LRB- cord-005453-4057qib7 12799 14 84 84 CD cord-005453-4057qib7 12799 15 transplantations transplantation NNS cord-005453-4057qib7 12799 16 ) ) -RRB- cord-005453-4057qib7 12799 17 varied vary VBN cord-005453-4057qib7 12799 18 between between IN cord-005453-4057qib7 12799 19 100x10 100x10 CD cord-005453-4057qib7 12799 20 6 6 CD cord-005453-4057qib7 12799 21 and and CC cord-005453-4057qib7 12799 22 250x10 250x10 CD cord-005453-4057qib7 12799 23 6 6 CD cord-005453-4057qib7 12799 24 cells cell NNS cord-005453-4057qib7 12799 25 / / SYM cord-005453-4057qib7 12799 26 ml ml NN cord-005453-4057qib7 12799 27 . . . cord-005453-4057qib7 12800 1 In in IN cord-005453-4057qib7 12800 2 an an DT cord-005453-4057qib7 12800 3 attempt attempt NN cord-005453-4057qib7 12800 4 to to TO cord-005453-4057qib7 12800 5 reduce reduce VB cord-005453-4057qib7 12800 6 the the DT cord-005453-4057qib7 12800 7 amount amount NN cord-005453-4057qib7 12800 8 of of IN cord-005453-4057qib7 12800 9 DMSO DMSO NNP cord-005453-4057qib7 12800 10 infused infuse VBN cord-005453-4057qib7 12800 11 , , , cord-005453-4057qib7 12800 12 for for IN cord-005453-4057qib7 12800 13 the the DT cord-005453-4057qib7 12800 14 rest rest NN cord-005453-4057qib7 12800 15 of of IN cord-005453-4057qib7 12800 16 the the DT cord-005453-4057qib7 12800 17 patients patient NNS cord-005453-4057qib7 12800 18 ( ( -LRB- cord-005453-4057qib7 12800 19 n=172 n=172 UH cord-005453-4057qib7 12800 20 ; ; : cord-005453-4057qib7 12800 21 192 192 CD cord-005453-4057qib7 12800 22 transplantations transplantation NNS cord-005453-4057qib7 12800 23 ) ) -RRB- cord-005453-4057qib7 12800 24 we -PRON- PRP cord-005453-4057qib7 12800 25 further further RB cord-005453-4057qib7 12800 26 decreased decrease VBD cord-005453-4057qib7 12800 27 the the DT cord-005453-4057qib7 12800 28 volume volume NN cord-005453-4057qib7 12800 29 of of IN cord-005453-4057qib7 12800 30 the the DT cord-005453-4057qib7 12800 31 freezing freeze VBG cord-005453-4057qib7 12800 32 suspension suspension NN cord-005453-4057qib7 12800 33 by by IN cord-005453-4057qib7 12800 34 removal removal NN cord-005453-4057qib7 12800 35 of of IN cord-005453-4057qib7 12800 36 the the DT cord-005453-4057qib7 12800 37 entire entire JJ cord-005453-4057qib7 12800 38 plasma plasma NN cord-005453-4057qib7 12800 39 . . . cord-005453-4057qib7 12801 1 The the DT cord-005453-4057qib7 12801 2 average average JJ cord-005453-4057qib7 12801 3 age age NN cord-005453-4057qib7 12801 4 of of IN cord-005453-4057qib7 12801 5 the the DT cord-005453-4057qib7 12801 6 transplanted transplanted JJ cord-005453-4057qib7 12801 7 patients patient NNS cord-005453-4057qib7 12801 8 was be VBD cord-005453-4057qib7 12801 9 55 55 CD cord-005453-4057qib7 12801 10 ( ( -LRB- cord-005453-4057qib7 12801 11 35 35 CD cord-005453-4057qib7 12801 12 -71 -71 NN cord-005453-4057qib7 12801 13 ) ) -RRB- cord-005453-4057qib7 12801 14 . . . cord-005453-4057qib7 12802 1 The the DT cord-005453-4057qib7 12802 2 cells cell NNS cord-005453-4057qib7 12802 3 were be VBD cord-005453-4057qib7 12802 4 bedside bedside NN cord-005453-4057qib7 12802 5 thawed thaw VBN cord-005453-4057qib7 12802 6 at at IN cord-005453-4057qib7 12802 7 37 37 CD cord-005453-4057qib7 12802 8 o o NN cord-005453-4057qib7 12802 9 C c NN cord-005453-4057qib7 12802 10 water water NN cord-005453-4057qib7 12802 11 bath bath NN cord-005453-4057qib7 12802 12 . . . cord-005453-4057qib7 12803 1 The the DT cord-005453-4057qib7 12803 2 average average JJ cord-005453-4057qib7 12803 3 cell cell NN cord-005453-4057qib7 12803 4 dose dose NN cord-005453-4057qib7 12803 5 was be VBD cord-005453-4057qib7 12803 6 2,95x10 2,95x10 CD cord-005453-4057qib7 12803 7 6 6 CD cord-005453-4057qib7 12803 8 /kg /kg . cord-005453-4057qib7 12804 1 ( ( -LRB- cord-005453-4057qib7 12804 2 1,3 1,3 CD cord-005453-4057qib7 12804 3 -9,2x10 -9,2x10 CD cord-005453-4057qib7 12804 4 6 6 CD cord-005453-4057qib7 12804 5 /kg /kg . cord-005453-4057qib7 12804 6 ) ) -RRB- cord-005453-4057qib7 12804 7 . . . cord-005453-4057qib7 12805 1 Results result NNS cord-005453-4057qib7 12805 2 : : : cord-005453-4057qib7 12805 3 Viability viability NN cord-005453-4057qib7 12805 4 of of IN cord-005453-4057qib7 12805 5 the the DT cord-005453-4057qib7 12805 6 stem stem NN cord-005453-4057qib7 12805 7 cells cell NNS cord-005453-4057qib7 12805 8 following follow VBG cord-005453-4057qib7 12805 9 thawing thaw VBG cord-005453-4057qib7 12805 10 assessed assess VBN cord-005453-4057qib7 12805 11 by by IN cord-005453-4057qib7 12805 12 trypan trypan NNP cord-005453-4057qib7 12805 13 blue blue JJ cord-005453-4057qib7 12805 14 exclusion exclusion NN cord-005453-4057qib7 12805 15 was be VBD cord-005453-4057qib7 12805 16 95,34 95,34 CD cord-005453-4057qib7 12805 17 % % NN cord-005453-4057qib7 12805 18 . . . cord-005453-4057qib7 12806 1 The the DT cord-005453-4057qib7 12806 2 hematocrit hematocrit NN cord-005453-4057qib7 12806 3 of of IN cord-005453-4057qib7 12806 4 the the DT cord-005453-4057qib7 12806 5 frozen frozen JJ cord-005453-4057qib7 12806 6 cells cell NNS cord-005453-4057qib7 12806 7 had have VBD cord-005453-4057qib7 12806 8 no no DT cord-005453-4057qib7 12806 9 effect effect NN cord-005453-4057qib7 12806 10 on on IN cord-005453-4057qib7 12806 11 cell cell NN cord-005453-4057qib7 12806 12 viability viability NN cord-005453-4057qib7 12806 13 ( ( -LRB- cord-005453-4057qib7 12806 14 94,80%(low 94,80%(low NN cord-005453-4057qib7 12806 15 ) ) -RRB- cord-005453-4057qib7 12806 16 vs vs IN cord-005453-4057qib7 12806 17 95,52%(high 95,52%(high CD cord-005453-4057qib7 12806 18 ) ) -RRB- cord-005453-4057qib7 12806 19 ) ) -RRB- cord-005453-4057qib7 12806 20 . . . cord-005453-4057qib7 12807 1 The the DT cord-005453-4057qib7 12807 2 major major JJ cord-005453-4057qib7 12807 3 complaints complaint NNS cord-005453-4057qib7 12807 4 , , , cord-005453-4057qib7 12807 5 if if IN cord-005453-4057qib7 12807 6 any any DT cord-005453-4057qib7 12807 7 , , , cord-005453-4057qib7 12807 8 during during IN cord-005453-4057qib7 12807 9 stem stem NN cord-005453-4057qib7 12807 10 cell cell NN cord-005453-4057qib7 12807 11 infusion infusion NN cord-005453-4057qib7 12807 12 were be VBD cord-005453-4057qib7 12807 13 coughing cough VBG cord-005453-4057qib7 12807 14 and and CC cord-005453-4057qib7 12807 15 an an DT cord-005453-4057qib7 12807 16 increase increase NN cord-005453-4057qib7 12807 17 in in IN cord-005453-4057qib7 12807 18 nausea nausea NN cord-005453-4057qib7 12807 19 and and CC cord-005453-4057qib7 12807 20 vomiting vomiting NN cord-005453-4057qib7 12807 21 induced induce VBN cord-005453-4057qib7 12807 22 by by IN cord-005453-4057qib7 12807 23 the the DT cord-005453-4057qib7 12807 24 prior prior JJ cord-005453-4057qib7 12807 25 conditioning conditioning NN cord-005453-4057qib7 12807 26 . . . cord-005453-4057qib7 12808 1 The the DT cord-005453-4057qib7 12808 2 average average JJ cord-005453-4057qib7 12808 3 time time NN cord-005453-4057qib7 12808 4 for for IN cord-005453-4057qib7 12808 5 hematological hematological JJ cord-005453-4057qib7 12808 6 recovery recovery NN cord-005453-4057qib7 12808 7 was be VBD cord-005453-4057qib7 12808 8 11,66 11,66 CD cord-005453-4057qib7 12808 9 days day NNS cord-005453-4057qib7 12808 10 ( ( -LRB- cord-005453-4057qib7 12808 11 between between IN cord-005453-4057qib7 12808 12 9 9 CD cord-005453-4057qib7 12808 13 and and CC cord-005453-4057qib7 12808 14 19 19 CD cord-005453-4057qib7 12808 15 ) ) -RRB- cord-005453-4057qib7 12808 16 for for IN cord-005453-4057qib7 12808 17 the the DT cord-005453-4057qib7 12808 18 neutrophils neutrophil NNS cord-005453-4057qib7 12808 19 , , , cord-005453-4057qib7 12808 20 and and CC cord-005453-4057qib7 12808 21 12,17 12,17 CD cord-005453-4057qib7 12808 22 ( ( -LRB- cord-005453-4057qib7 12808 23 between between IN cord-005453-4057qib7 12808 24 9 9 CD cord-005453-4057qib7 12808 25 and and CC cord-005453-4057qib7 12808 26 20 20 CD cord-005453-4057qib7 12808 27 ) ) -RRB- cord-005453-4057qib7 12808 28 days day NNS cord-005453-4057qib7 12808 29 for for IN cord-005453-4057qib7 12808 30 the the DT cord-005453-4057qib7 12808 31 platelets platelet NNS cord-005453-4057qib7 12808 32 . . . cord-005453-4057qib7 12809 1 There there EX cord-005453-4057qib7 12809 2 was be VBD cord-005453-4057qib7 12809 3 no no DT cord-005453-4057qib7 12809 4 significant significant JJ cord-005453-4057qib7 12809 5 difference difference NN cord-005453-4057qib7 12809 6 in in IN cord-005453-4057qib7 12809 7 viability viability NN cord-005453-4057qib7 12809 8 and and CC cord-005453-4057qib7 12809 9 hematologic hematologic JJ cord-005453-4057qib7 12809 10 recovery recovery NN cord-005453-4057qib7 12809 11 ( ( -LRB- cord-005453-4057qib7 12809 12 11,86 11,86 CD cord-005453-4057qib7 12809 13 and and CC cord-005453-4057qib7 12809 14 12,60 12,60 CD cord-005453-4057qib7 12809 15 vs vs IN cord-005453-4057qib7 12809 16 11,59 11,59 CD cord-005453-4057qib7 12809 17 and and CC cord-005453-4057qib7 12809 18 12,02 12,02 CD cord-005453-4057qib7 12809 19 ) ) -RRB- cord-005453-4057qib7 12809 20 between between IN cord-005453-4057qib7 12809 21 patients patient NNS cord-005453-4057qib7 12809 22 receiving receive VBG cord-005453-4057qib7 12809 23 cells cell NNS cord-005453-4057qib7 12809 24 frozen freeze VBN cord-005453-4057qib7 12809 25 with with IN cord-005453-4057qib7 12809 26 low low JJ cord-005453-4057qib7 12809 27 or or CC cord-005453-4057qib7 12809 28 high high JJ cord-005453-4057qib7 12809 29 hematocrit hematocrit NN cord-005453-4057qib7 12809 30 . . . cord-005453-4057qib7 12810 1 Conclusions conclusion NNS cord-005453-4057qib7 12810 2 : : : cord-005453-4057qib7 12811 1 Dimethylsulfoxide Dimethylsulfoxide NNP cord-005453-4057qib7 12811 2 , , , cord-005453-4057qib7 12811 3 despite despite IN cord-005453-4057qib7 12811 4 its -PRON- PRP$ cord-005453-4057qib7 12811 5 cryoprotective cryoprotective JJ cord-005453-4057qib7 12811 6 properties property NNS cord-005453-4057qib7 12811 7 , , , cord-005453-4057qib7 12811 8 is be VBZ cord-005453-4057qib7 12811 9 toxic toxic JJ cord-005453-4057qib7 12811 10 for for IN cord-005453-4057qib7 12811 11 stem stem NN cord-005453-4057qib7 12811 12 cells cell NNS cord-005453-4057qib7 12811 13 at at IN cord-005453-4057qib7 12811 14 temperatures temperature NNS cord-005453-4057qib7 12811 15 above above IN cord-005453-4057qib7 12811 16 zero zero CD cord-005453-4057qib7 12811 17 C c NN cord-005453-4057qib7 12811 18 and and CC cord-005453-4057qib7 12811 19 induces induce VBZ cord-005453-4057qib7 12811 20 many many JJ cord-005453-4057qib7 12811 21 side side NN cord-005453-4057qib7 12811 22 effects effect NNS cord-005453-4057qib7 12811 23 ( ( -LRB- cord-005453-4057qib7 12811 24 cardiac cardiac JJ cord-005453-4057qib7 12811 25 , , , cord-005453-4057qib7 12811 26 neurologic neurologic JJ cord-005453-4057qib7 12811 27 , , , cord-005453-4057qib7 12811 28 respiratory respiratory JJ cord-005453-4057qib7 12811 29 , , , cord-005453-4057qib7 12811 30 etc etc FW cord-005453-4057qib7 12811 31 . . . cord-005453-4057qib7 12811 32 ) ) -RRB- cord-005453-4057qib7 12812 1 in in IN cord-005453-4057qib7 12812 2 the the DT cord-005453-4057qib7 12812 3 patients patient NNS cord-005453-4057qib7 12812 4 . . . cord-005453-4057qib7 12813 1 To to TO cord-005453-4057qib7 12813 2 reduce reduce VB cord-005453-4057qib7 12813 3 those those DT cord-005453-4057qib7 12813 4 side side NN cord-005453-4057qib7 12813 5 effects effect NNS cord-005453-4057qib7 12813 6 we -PRON- PRP cord-005453-4057qib7 12813 7 use use VBP cord-005453-4057qib7 12813 8 lower low JJR cord-005453-4057qib7 12813 9 DMSO DMSO NNP cord-005453-4057qib7 12813 10 concentration concentration NN cord-005453-4057qib7 12813 11 , , , cord-005453-4057qib7 12813 12 high high JJ cord-005453-4057qib7 12813 13 hematocrit hematocrit NN cord-005453-4057qib7 12813 14 resulting result VBG cord-005453-4057qib7 12813 15 in in IN cord-005453-4057qib7 12813 16 lower low JJR cord-005453-4057qib7 12813 17 volume volume NN cord-005453-4057qib7 12813 18 of of IN cord-005453-4057qib7 12813 19 the the DT cord-005453-4057qib7 12813 20 frozen frozen JJ cord-005453-4057qib7 12813 21 cell cell NN cord-005453-4057qib7 12813 22 suspension suspension NN cord-005453-4057qib7 12813 23 , , , cord-005453-4057qib7 12813 24 thus thus RB cord-005453-4057qib7 12813 25 reducing reduce VBG cord-005453-4057qib7 12813 26 the the DT cord-005453-4057qib7 12813 27 final final JJ cord-005453-4057qib7 12813 28 quantity quantity NN cord-005453-4057qib7 12813 29 of of IN cord-005453-4057qib7 12813 30 DMSO DMSO NNP cord-005453-4057qib7 12813 31 to to TO cord-005453-4057qib7 12813 32 be be VB cord-005453-4057qib7 12813 33 infused infuse VBN cord-005453-4057qib7 12813 34 to to IN cord-005453-4057qib7 12813 35 the the DT cord-005453-4057qib7 12813 36 patients patient NNS cord-005453-4057qib7 12813 37 . . . cord-005453-4057qib7 12814 1 This this DT cord-005453-4057qib7 12814 2 does do VBZ cord-005453-4057qib7 12814 3 not not RB cord-005453-4057qib7 12814 4 affect affect VB cord-005453-4057qib7 12814 5 the the DT cord-005453-4057qib7 12814 6 cell cell NN cord-005453-4057qib7 12814 7 viability viability NN cord-005453-4057qib7 12814 8 or or CC cord-005453-4057qib7 12814 9 the the DT cord-005453-4057qib7 12814 10 hematologic hematologic JJ cord-005453-4057qib7 12814 11 recovery recovery NN cord-005453-4057qib7 12814 12 of of IN cord-005453-4057qib7 12814 13 patients patient NNS cord-005453-4057qib7 12814 14 after after IN cord-005453-4057qib7 12814 15 transplantation transplantation NN cord-005453-4057qib7 12814 16 . . . cord-005453-4057qib7 12815 1 Our -PRON- PRP$ cord-005453-4057qib7 12815 2 easily easily RB cord-005453-4057qib7 12815 3 performed perform VBN cord-005453-4057qib7 12815 4 method method NN cord-005453-4057qib7 12815 5 for for IN cord-005453-4057qib7 12815 6 unprogrammed unprogrammed JJ cord-005453-4057qib7 12815 7 freezing freezing NN cord-005453-4057qib7 12815 8 of of IN cord-005453-4057qib7 12815 9 stem stem NN cord-005453-4057qib7 12815 10 cells cell NNS cord-005453-4057qib7 12815 11 with with IN cord-005453-4057qib7 12815 12 final final JJ cord-005453-4057qib7 12815 13 DMSO DMSO NNP cord-005453-4057qib7 12815 14 concentration concentration NN cord-005453-4057qib7 12815 15 5 5 CD cord-005453-4057qib7 12815 16 % % NN cord-005453-4057qib7 12815 17 at at IN cord-005453-4057qib7 12815 18 -80 -80 NNP cord-005453-4057qib7 12815 19 o o NN cord-005453-4057qib7 12815 20 C C NNP cord-005453-4057qib7 12815 21 is be VBZ cord-005453-4057qib7 12815 22 safe safe JJ cord-005453-4057qib7 12815 23 , , , cord-005453-4057qib7 12815 24 well well RB cord-005453-4057qib7 12815 25 tolerated tolerate VBN cord-005453-4057qib7 12815 26 , , , cord-005453-4057qib7 12815 27 and and CC cord-005453-4057qib7 12815 28 provides provide VBZ cord-005453-4057qib7 12815 29 cryopreservation cryopreservation NN cord-005453-4057qib7 12815 30 , , , cord-005453-4057qib7 12815 31 which which WDT cord-005453-4057qib7 12815 32 allows allow VBZ cord-005453-4057qib7 12815 33 high high JJ cord-005453-4057qib7 12815 34 viability viability NN cord-005453-4057qib7 12815 35 and and CC cord-005453-4057qib7 12815 36 stable stable JJ cord-005453-4057qib7 12815 37 cell cell NN cord-005453-4057qib7 12815 38 engraftment engraftment NN cord-005453-4057qib7 12815 39 , , , cord-005453-4057qib7 12815 40 while while IN cord-005453-4057qib7 12815 41 reducing reduce VBG cord-005453-4057qib7 12815 42 the the DT cord-005453-4057qib7 12815 43 undesired undesired JJ cord-005453-4057qib7 12815 44 side side NN cord-005453-4057qib7 12815 45 effects effect NNS cord-005453-4057qib7 12815 46 of of IN cord-005453-4057qib7 12815 47 DMSO DMSO NNP cord-005453-4057qib7 12815 48 . . . cord-005453-4057qib7 12816 1 Disclosure disclosure NN cord-005453-4057qib7 12816 2 : : : cord-005453-4057qib7 12816 3 Nothing nothing NN cord-005453-4057qib7 12816 4 to to TO cord-005453-4057qib7 12816 5 disclose disclose VB cord-005453-4057qib7 12816 6 The the DT cord-005453-4057qib7 12816 7 conditioning conditioning NN cord-005453-4057qib7 12816 8 regimen regimen NN cord-005453-4057qib7 12816 9 consisted consist VBD cord-005453-4057qib7 12816 10 of of IN cord-005453-4057qib7 12816 11 Melphalan Melphalan NNP cord-005453-4057qib7 12816 12 for for IN cord-005453-4057qib7 12816 13 most most JJS cord-005453-4057qib7 12816 14 of of IN cord-005453-4057qib7 12816 15 the the DT cord-005453-4057qib7 12816 16 patients patient NNS cord-005453-4057qib7 12816 17 . . . cord-005453-4057qib7 12817 1 The the DT cord-005453-4057qib7 12817 2 average average JJ cord-005453-4057qib7 12817 3 age age NN cord-005453-4057qib7 12817 4 at at IN cord-005453-4057qib7 12817 5 the the DT cord-005453-4057qib7 12817 6 time time NN cord-005453-4057qib7 12817 7 of of IN cord-005453-4057qib7 12817 8 transplantation transplantation NN cord-005453-4057qib7 12817 9 was be VBD cord-005453-4057qib7 12817 10 55 55 CD cord-005453-4057qib7 12817 11 years year NNS cord-005453-4057qib7 12817 12 ( ( -LRB- cord-005453-4057qib7 12817 13 35 35 CD cord-005453-4057qib7 12817 14 -71 -71 NN cord-005453-4057qib7 12817 15 ) ) -RRB- cord-005453-4057qib7 12817 16 . . . cord-005453-4057qib7 12818 1 Patients patient NNS cord-005453-4057qib7 12818 2 were be VBD cord-005453-4057qib7 12818 3 transplanted transplant VBN cord-005453-4057qib7 12818 4 with with IN cord-005453-4057qib7 12818 5 an an DT cord-005453-4057qib7 12818 6 average average JJ cord-005453-4057qib7 12818 7 cell cell NN cord-005453-4057qib7 12818 8 dose dose NN cord-005453-4057qib7 12818 9 of of IN cord-005453-4057qib7 12818 10 2,95x10 2,95x10 CD cord-005453-4057qib7 12818 11 6 6 CD cord-005453-4057qib7 12818 12 /kg /kg . cord-005453-4057qib7 12819 1 ( ( -LRB- cord-005453-4057qib7 12819 2 1,30 1,30 CD cord-005453-4057qib7 12819 3 -9,20x10 -9,20x10 NNP cord-005453-4057qib7 12819 4 6 6 CD cord-005453-4057qib7 12819 5 /kg /kg NFP cord-005453-4057qib7 12819 6 ) ) -RRB- cord-005453-4057qib7 12819 7 for for IN cord-005453-4057qib7 12819 8 the the DT cord-005453-4057qib7 12819 9 first first JJ cord-005453-4057qib7 12819 10 transplantation transplantation NN cord-005453-4057qib7 12819 11 and and CC cord-005453-4057qib7 12819 12 2,36x10 2,36x10 CD cord-005453-4057qib7 12819 13 6 6 CD cord-005453-4057qib7 12819 14 /kg /kg . cord-005453-4057qib7 12819 15 ( ( -LRB- cord-005453-4057qib7 12819 16 1,64 1,64 CD cord-005453-4057qib7 12819 17 -3,19x10 -3,19x10 NNP cord-005453-4057qib7 12819 18 6 6 CD cord-005453-4057qib7 12819 19 /kg /kg NFP cord-005453-4057qib7 12819 20 ) ) -RRB- cord-005453-4057qib7 12819 21 for for IN cord-005453-4057qib7 12819 22 the the DT cord-005453-4057qib7 12819 23 second second JJ cord-005453-4057qib7 12819 24 one one CD cord-005453-4057qib7 12820 1 ( ( -LRB- cord-005453-4057qib7 12820 2 every every DT cord-005453-4057qib7 12820 3 patient patient NN cord-005453-4057qib7 12820 4 received receive VBD cord-005453-4057qib7 12820 5 the the DT cord-005453-4057qib7 12820 6 same same JJ cord-005453-4057qib7 12820 7 cell cell NN cord-005453-4057qib7 12820 8 dose dose NN cord-005453-4057qib7 12820 9 as as IN cord-005453-4057qib7 12820 10 for for IN cord-005453-4057qib7 12820 11 the the DT cord-005453-4057qib7 12820 12 first first JJ cord-005453-4057qib7 12820 13 ) ) -RRB- cord-005453-4057qib7 12820 14 with with IN cord-005453-4057qib7 12820 15 average average JJ cord-005453-4057qib7 12820 16 cell cell NN cord-005453-4057qib7 12820 17 viability viability NN cord-005453-4057qib7 12820 18 95,34 95,34 CD cord-005453-4057qib7 12820 19 % % NN cord-005453-4057qib7 12820 20 ( ( -LRB- cord-005453-4057qib7 12820 21 70 70 CD cord-005453-4057qib7 12820 22 -99 -99 NN cord-005453-4057qib7 12820 23 % % NN cord-005453-4057qib7 12820 24 ) ) -RRB- cord-005453-4057qib7 12820 25 , , , cord-005453-4057qib7 12820 26 with with IN cord-005453-4057qib7 12820 27 little little JJ cord-005453-4057qib7 12820 28 difference difference NN cord-005453-4057qib7 12820 29 between between IN cord-005453-4057qib7 12820 30 first first JJ cord-005453-4057qib7 12820 31 and and CC cord-005453-4057qib7 12820 32 second second JJ cord-005453-4057qib7 12820 33 transplantation transplantation NN cord-005453-4057qib7 12820 34 . . . cord-005453-4057qib7 12821 1 Results result NNS cord-005453-4057qib7 12821 2 : : : cord-005453-4057qib7 12822 1 The the DT cord-005453-4057qib7 12822 2 average average JJ cord-005453-4057qib7 12822 3 time time NN cord-005453-4057qib7 12822 4 for for IN cord-005453-4057qib7 12822 5 hematological hematological JJ cord-005453-4057qib7 12822 6 recovery recovery NN cord-005453-4057qib7 12822 7 was be VBD cord-005453-4057qib7 12822 8 11,60 11,60 CD cord-005453-4057qib7 12822 9 ( ( -LRB- cord-005453-4057qib7 12822 10 between between IN cord-005453-4057qib7 12822 11 9 9 CD cord-005453-4057qib7 12822 12 and and CC cord-005453-4057qib7 12822 13 19 19 CD cord-005453-4057qib7 12822 14 ) ) -RRB- cord-005453-4057qib7 12822 15 days day NNS cord-005453-4057qib7 12822 16 for for IN cord-005453-4057qib7 12822 17 the the DT cord-005453-4057qib7 12822 18 neutrophils neutrophil NNS cord-005453-4057qib7 12822 19 , , , cord-005453-4057qib7 12822 20 and and CC cord-005453-4057qib7 12822 21 12.11 12.11 CD cord-005453-4057qib7 12822 22 ( ( -LRB- cord-005453-4057qib7 12822 23 between between IN cord-005453-4057qib7 12822 24 9 9 CD cord-005453-4057qib7 12822 25 and and CC cord-005453-4057qib7 12822 26 20 20 CD cord-005453-4057qib7 12822 27 ) ) -RRB- cord-005453-4057qib7 12822 28 days day NNS cord-005453-4057qib7 12822 29 for for IN cord-005453-4057qib7 12822 30 the the DT cord-005453-4057qib7 12822 31 platelets platelet NNS cord-005453-4057qib7 12822 32 . . . cord-005453-4057qib7 12823 1 We -PRON- PRP cord-005453-4057qib7 12823 2 found find VBD cord-005453-4057qib7 12823 3 no no DT cord-005453-4057qib7 12823 4 correlation correlation NN cord-005453-4057qib7 12823 5 between between IN cord-005453-4057qib7 12823 6 the the DT cord-005453-4057qib7 12823 7 cell cell NN cord-005453-4057qib7 12823 8 dose dose NN cord-005453-4057qib7 12823 9 and and CC cord-005453-4057qib7 12823 10 the the DT cord-005453-4057qib7 12823 11 hematological hematological JJ cord-005453-4057qib7 12823 12 recovery recovery NN cord-005453-4057qib7 12823 13 . . . cord-005453-4057qib7 12824 1 There there EX cord-005453-4057qib7 12824 2 was be VBD cord-005453-4057qib7 12824 3 no no DT cord-005453-4057qib7 12824 4 difference difference NN cord-005453-4057qib7 12824 5 in in IN cord-005453-4057qib7 12824 6 the the DT cord-005453-4057qib7 12824 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 12824 8 recovery recovery NN cord-005453-4057qib7 12824 9 between between IN cord-005453-4057qib7 12824 10 the the DT cord-005453-4057qib7 12824 11 first first JJ cord-005453-4057qib7 12824 12 and and CC cord-005453-4057qib7 12824 13 the the DT cord-005453-4057qib7 12824 14 second second JJ cord-005453-4057qib7 12824 15 transplantation transplantation NN cord-005453-4057qib7 12824 16 in in IN cord-005453-4057qib7 12824 17 the the DT cord-005453-4057qib7 12824 18 patients patient NNS cord-005453-4057qib7 12824 19 , , , cord-005453-4057qib7 12824 20 who who WP cord-005453-4057qib7 12824 21 underwent undergo VBD cord-005453-4057qib7 12824 22 tandem tandem NN cord-005453-4057qib7 12824 23 or or CC cord-005453-4057qib7 12824 24 two two CD cord-005453-4057qib7 12824 25 transplantations transplantation NNS cord-005453-4057qib7 12824 26 . . . cord-005453-4057qib7 12825 1 Conclusions conclusion NNS cord-005453-4057qib7 12825 2 : : : cord-005453-4057qib7 12826 1 Recovery recovery NN cord-005453-4057qib7 12826 2 time time NN cord-005453-4057qib7 12826 3 is be VBZ cord-005453-4057qib7 12826 4 considered consider VBN cord-005453-4057qib7 12826 5 by by IN cord-005453-4057qib7 12826 6 some some DT cord-005453-4057qib7 12826 7 to to TO cord-005453-4057qib7 12826 8 be be VB cord-005453-4057qib7 12826 9 a a DT cord-005453-4057qib7 12826 10 function function NN cord-005453-4057qib7 12826 11 of of IN cord-005453-4057qib7 12826 12 the the DT cord-005453-4057qib7 12826 13 effective effective JJ cord-005453-4057qib7 12826 14 stem stem NN cord-005453-4057qib7 12826 15 cell cell NN cord-005453-4057qib7 12826 16 number number NN cord-005453-4057qib7 12826 17 . . . cord-005453-4057qib7 12827 1 We -PRON- PRP cord-005453-4057qib7 12827 2 did do VBD cord-005453-4057qib7 12827 3 not not RB cord-005453-4057qib7 12827 4 find find VB cord-005453-4057qib7 12827 5 such such JJ cord-005453-4057qib7 12827 6 correlation correlation NN cord-005453-4057qib7 12827 7 , , , cord-005453-4057qib7 12827 8 probably probably RB cord-005453-4057qib7 12827 9 because because IN cord-005453-4057qib7 12827 10 in in IN cord-005453-4057qib7 12827 11 the the DT cord-005453-4057qib7 12827 12 analyzed analyze VBN cord-005453-4057qib7 12827 13 group group NN cord-005453-4057qib7 12827 14 all all PDT cord-005453-4057qib7 12827 15 the the DT cord-005453-4057qib7 12827 16 patients patient NNS cord-005453-4057qib7 12827 17 , , , cord-005453-4057qib7 12827 18 except except IN cord-005453-4057qib7 12827 19 four four CD cord-005453-4057qib7 12827 20 of of IN cord-005453-4057qib7 12827 21 them -PRON- PRP cord-005453-4057qib7 12827 22 , , , cord-005453-4057qib7 12827 23 received receive VBD cord-005453-4057qib7 12827 24 a a DT cord-005453-4057qib7 12827 25 dose dose NN cord-005453-4057qib7 12827 26 greater great JJR cord-005453-4057qib7 12827 27 than than IN cord-005453-4057qib7 12827 28 2 2 CD cord-005453-4057qib7 12827 29 x10 x10 CD cord-005453-4057qib7 12827 30 6 6 CD cord-005453-4057qib7 12827 31 /kg /kg CD cord-005453-4057qib7 12827 32 cell cell NN cord-005453-4057qib7 12827 33 , , , cord-005453-4057qib7 12827 34 which which WDT cord-005453-4057qib7 12827 35 is be VBZ cord-005453-4057qib7 12827 36 accepted accept VBN cord-005453-4057qib7 12827 37 as as IN cord-005453-4057qib7 12827 38 a a DT cord-005453-4057qib7 12827 39 safe safe JJ cord-005453-4057qib7 12827 40 dose dose NN cord-005453-4057qib7 12827 41 for for IN cord-005453-4057qib7 12827 42 autologous autologous JJ cord-005453-4057qib7 12827 43 stem stem NN cord-005453-4057qib7 12827 44 cell cell NN cord-005453-4057qib7 12827 45 transplantation transplantation NN cord-005453-4057qib7 12827 46 . . . cord-005453-4057qib7 12828 1 Disclosure disclosure NN cord-005453-4057qib7 12828 2 : : : cord-005453-4057qib7 12828 3 Nothing nothing NN cord-005453-4057qib7 12828 4 to to TO cord-005453-4057qib7 12828 5 disclose disclose VB cord-005453-4057qib7 12828 6 P569 P569 NNP cord-005453-4057qib7 12828 7 Plerixafor Plerixafor NNP cord-005453-4057qib7 12828 8 - - HYPH cord-005453-4057qib7 12828 9 mobilized mobilize VBN cord-005453-4057qib7 12828 10 patients patient NNS cord-005453-4057qib7 12828 11 have have VBP cord-005453-4057qib7 12828 12 a a DT cord-005453-4057qib7 12828 13 high high JJ cord-005453-4057qib7 12828 14 risk risk NN cord-005453-4057qib7 12828 15 of of IN cord-005453-4057qib7 12828 16 noninfectious noninfectious JJ cord-005453-4057qib7 12828 17 fever fever NN cord-005453-4057qib7 12828 18 during during IN cord-005453-4057qib7 12828 19 engraftment engraftment NN cord-005453-4057qib7 12828 20 after after IN cord-005453-4057qib7 12828 21 autologous autologous JJ cord-005453-4057qib7 12828 22 peripheral peripheral JJ cord-005453-4057qib7 12828 23 blood blood NN cord-005453-4057qib7 12828 24 stem stem NN cord-005453-4057qib7 12828 25 cell cell NN cord-005453-4057qib7 12828 26 transplantation transplantation NN cord-005453-4057qib7 12828 27 Background background NN cord-005453-4057qib7 12828 28 : : : cord-005453-4057qib7 12828 29 Plerixafor Plerixafor NNP cord-005453-4057qib7 12828 30 enables enable VBZ cord-005453-4057qib7 12828 31 rapid rapid JJ cord-005453-4057qib7 12828 32 and and CC cord-005453-4057qib7 12828 33 efficient efficient JJ cord-005453-4057qib7 12828 34 mobilization mobilization NN cord-005453-4057qib7 12828 35 of of IN cord-005453-4057qib7 12828 36 hematopoietic hematopoietic JJ cord-005453-4057qib7 12828 37 stem stem NN cord-005453-4057qib7 12828 38 cells cell NNS cord-005453-4057qib7 12828 39 . . . cord-005453-4057qib7 12829 1 However however RB cord-005453-4057qib7 12829 2 , , , cord-005453-4057qib7 12829 3 its -PRON- PRP$ cord-005453-4057qib7 12829 4 impact impact NN cord-005453-4057qib7 12829 5 on on IN cord-005453-4057qib7 12829 6 adverse adverse JJ cord-005453-4057qib7 12829 7 clinical clinical JJ cord-005453-4057qib7 12829 8 events event NNS cord-005453-4057qib7 12829 9 after after IN cord-005453-4057qib7 12829 10 autologous autologous JJ cord-005453-4057qib7 12829 11 peripheral peripheral JJ cord-005453-4057qib7 12829 12 blood blood NN cord-005453-4057qib7 12829 13 stem stem NN cord-005453-4057qib7 12829 14 cell cell NN cord-005453-4057qib7 12829 15 transplantation transplantation NN cord-005453-4057qib7 12829 16 ( ( -LRB- cord-005453-4057qib7 12829 17 PBSCT PBSCT NNP cord-005453-4057qib7 12829 18 ) ) -RRB- cord-005453-4057qib7 12829 19 is be VBZ cord-005453-4057qib7 12829 20 not not RB cord-005453-4057qib7 12829 21 fully fully RB cord-005453-4057qib7 12829 22 understood understand VBN cord-005453-4057qib7 12829 23 . . . cord-005453-4057qib7 12830 1 Fever fever NN cord-005453-4057qib7 12830 2 is be VBZ cord-005453-4057qib7 12830 3 one one CD cord-005453-4057qib7 12830 4 of of IN cord-005453-4057qib7 12830 5 the the DT cord-005453-4057qib7 12830 6 major major JJ cord-005453-4057qib7 12830 7 complications complication NNS cord-005453-4057qib7 12830 8 in in IN cord-005453-4057qib7 12830 9 the the DT cord-005453-4057qib7 12830 10 preengraftment preengraftment NN cord-005453-4057qib7 12830 11 phase phase NN cord-005453-4057qib7 12830 12 of of IN cord-005453-4057qib7 12830 13 PBSCT PBSCT NNP cord-005453-4057qib7 12830 14 . . . cord-005453-4057qib7 12831 1 In in IN cord-005453-4057qib7 12831 2 this this DT cord-005453-4057qib7 12831 3 research research NN cord-005453-4057qib7 12831 4 , , , cord-005453-4057qib7 12831 5 we -PRON- PRP cord-005453-4057qib7 12831 6 focused focus VBD cord-005453-4057qib7 12831 7 on on IN cord-005453-4057qib7 12831 8 non non JJ cord-005453-4057qib7 12831 9 - - JJ cord-005453-4057qib7 12831 10 infectious infectious JJ cord-005453-4057qib7 12831 11 fever fever NN cord-005453-4057qib7 12831 12 around around IN cord-005453-4057qib7 12831 13 the the DT cord-005453-4057qib7 12831 14 time time NN cord-005453-4057qib7 12831 15 of of IN cord-005453-4057qib7 12831 16 bone bone NN cord-005453-4057qib7 12831 17 marrow marrow NN cord-005453-4057qib7 12831 18 recovery recovery NN cord-005453-4057qib7 12831 19 and and CC cord-005453-4057qib7 12831 20 investigated investigate VBD cord-005453-4057qib7 12831 21 whether whether IN cord-005453-4057qib7 12831 22 plerixafor plerixafor NN cord-005453-4057qib7 12831 23 as as IN cord-005453-4057qib7 12831 24 mobilization mobilization NN cord-005453-4057qib7 12831 25 therapy therapy NN cord-005453-4057qib7 12831 26 plays play VBZ cord-005453-4057qib7 12831 27 a a DT cord-005453-4057qib7 12831 28 role role NN cord-005453-4057qib7 12831 29 in in IN cord-005453-4057qib7 12831 30 engraftment engraftment NN cord-005453-4057qib7 12831 31 fever fever NN cord-005453-4057qib7 12831 32 . . . cord-005453-4057qib7 12832 1 Methods method NNS cord-005453-4057qib7 12832 2 : : : cord-005453-4057qib7 12832 3 We -PRON- PRP cord-005453-4057qib7 12832 4 reviewed review VBD cord-005453-4057qib7 12832 5 80 80 CD cord-005453-4057qib7 12832 6 autologous autologous JJ cord-005453-4057qib7 12832 7 PBSCTs pbsct NNS cord-005453-4057qib7 12832 8 for for IN cord-005453-4057qib7 12832 9 treatment treatment NN cord-005453-4057qib7 12832 10 of of IN cord-005453-4057qib7 12832 11 multiple multiple JJ cord-005453-4057qib7 12832 12 myeloma myeloma NN cord-005453-4057qib7 12832 13 at at IN cord-005453-4057qib7 12832 14 the the DT cord-005453-4057qib7 12832 15 Japanese japanese JJ cord-005453-4057qib7 12832 16 Red Red NNP cord-005453-4057qib7 12832 17 Cross Cross NNP cord-005453-4057qib7 12832 18 Medical Medical NNP cord-005453-4057qib7 12832 19 Center Center NNP cord-005453-4057qib7 12832 20 between between IN cord-005453-4057qib7 12832 21 2012 2012 CD cord-005453-4057qib7 12832 22 - - SYM cord-005453-4057qib7 12832 23 2018 2018 CD cord-005453-4057qib7 12832 24 . . . cord-005453-4057qib7 12833 1 Non non JJ cord-005453-4057qib7 12833 2 - - JJ cord-005453-4057qib7 12833 3 infectious infectious JJ cord-005453-4057qib7 12833 4 fever fever NN cord-005453-4057qib7 12833 5 was be VBD cord-005453-4057qib7 12833 6 defined define VBN cord-005453-4057qib7 12833 7 as as IN cord-005453-4057qib7 12833 8 temperature temperature NN cord-005453-4057qib7 12833 9 ≥37 ≥37 IN cord-005453-4057qib7 12833 10 ° ° NN cord-005453-4057qib7 12833 11 C c NN cord-005453-4057qib7 12833 12 with with IN cord-005453-4057qib7 12833 13 onset onset NN cord-005453-4057qib7 12833 14 between between IN cord-005453-4057qib7 12833 15 two two CD cord-005453-4057qib7 12833 16 days day NNS cord-005453-4057qib7 12833 17 prior prior RB cord-005453-4057qib7 12833 18 to to IN cord-005453-4057qib7 12833 19 and and CC cord-005453-4057qib7 12833 20 two two CD cord-005453-4057qib7 12833 21 days day NNS cord-005453-4057qib7 12833 22 after after IN cord-005453-4057qib7 12833 23 engraftment engraftment NN cord-005453-4057qib7 12833 24 without without IN cord-005453-4057qib7 12833 25 clinical clinical JJ cord-005453-4057qib7 12833 26 or or CC cord-005453-4057qib7 12833 27 microbiological microbiological JJ cord-005453-4057qib7 12833 28 documentation documentation NN cord-005453-4057qib7 12833 29 of of IN cord-005453-4057qib7 12833 30 infection infection NN cord-005453-4057qib7 12833 31 . . . cord-005453-4057qib7 12834 1 Results result NNS cord-005453-4057qib7 12834 2 : : : cord-005453-4057qib7 12835 1 Patients patient NNS cord-005453-4057qib7 12835 2 were be VBD cord-005453-4057qib7 12835 3 mobilized mobilize VBN cord-005453-4057qib7 12835 4 by by IN cord-005453-4057qib7 12835 5 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12835 6 and and CC cord-005453-4057qib7 12835 7 filgrastim filgrastim NN cord-005453-4057qib7 12835 8 in in IN cord-005453-4057qib7 12835 9 57.5 57.5 CD cord-005453-4057qib7 12835 10 % % NN cord-005453-4057qib7 12835 11 ( ( -LRB- cord-005453-4057qib7 12835 12 n n NN cord-005453-4057qib7 12835 13 = = SYM cord-005453-4057qib7 12835 14 46 46 CD cord-005453-4057qib7 12835 15 ) ) -RRB- cord-005453-4057qib7 12835 16 and and CC cord-005453-4057qib7 12835 17 filgrastim filgrastim NN cord-005453-4057qib7 12835 18 and and CC cord-005453-4057qib7 12835 19 plerixafor plerixafor NN cord-005453-4057qib7 12835 20 in in IN cord-005453-4057qib7 12835 21 42.5 42.5 CD cord-005453-4057qib7 12835 22 % % NN cord-005453-4057qib7 12835 23 ( ( -LRB- cord-005453-4057qib7 12835 24 n n NN cord-005453-4057qib7 12835 25 = = SYM cord-005453-4057qib7 12835 26 34 34 CD cord-005453-4057qib7 12835 27 ) ) -RRB- cord-005453-4057qib7 12835 28 . . . cord-005453-4057qib7 12836 1 The the DT cord-005453-4057qib7 12836 2 median median JJ cord-005453-4057qib7 12836 3 number number NN cord-005453-4057qib7 12836 4 of of IN cord-005453-4057qib7 12836 5 transfused transfuse VBN cord-005453-4057qib7 12836 6 CD34 CD34 NNP cord-005453-4057qib7 12836 7 + + CC cord-005453-4057qib7 12836 8 cells cell NNS cord-005453-4057qib7 12836 9 were be VBD cord-005453-4057qib7 12836 10 2.61×10 2.61×10 CD cord-005453-4057qib7 12836 11 6 6 CD cord-005453-4057qib7 12837 1 /kg /kg . cord-005453-4057qib7 12838 1 and and CC cord-005453-4057qib7 12838 2 3.45×10 3.45×10 CD cord-005453-4057qib7 12838 3 6 6 CD cord-005453-4057qib7 12838 4 / / SYM cord-005453-4057qib7 12838 5 kg kg NNS cord-005453-4057qib7 12838 6 , , , cord-005453-4057qib7 12838 7 respectively respectively RB cord-005453-4057qib7 12838 8 ( ( -LRB- cord-005453-4057qib7 12838 9 P=0.002 P=0.002 NNP cord-005453-4057qib7 12838 10 ) ) -RRB- cord-005453-4057qib7 12838 11 . . . cord-005453-4057qib7 12839 1 Patients patient NNS cord-005453-4057qib7 12839 2 transfused transfuse VBN cord-005453-4057qib7 12839 3 with with IN cord-005453-4057qib7 12839 4 plerixafor plerixafor NN cord-005453-4057qib7 12839 5 - - HYPH cord-005453-4057qib7 12839 6 mobilized mobilize VBN cord-005453-4057qib7 12839 7 grafts graft NNS cord-005453-4057qib7 12839 8 had have VBD cord-005453-4057qib7 12839 9 a a DT cord-005453-4057qib7 12839 10 higher high JJR cord-005453-4057qib7 12839 11 risk risk NN cord-005453-4057qib7 12839 12 of of IN cord-005453-4057qib7 12839 13 noninfectious noninfectious JJ cord-005453-4057qib7 12839 14 fever fever NN cord-005453-4057qib7 12839 15 ( ( -LRB- cord-005453-4057qib7 12839 16 85.3 85.3 CD cord-005453-4057qib7 12839 17 % % NN cord-005453-4057qib7 12839 18 vs vs IN cord-005453-4057qib7 12839 19 63.0 63.0 CD cord-005453-4057qib7 12839 20 % % NN cord-005453-4057qib7 12839 21 , , , cord-005453-4057qib7 12839 22 P p NN cord-005453-4057qib7 12839 23 < < XX cord-005453-4057qib7 12839 24 0.05 0.05 CD cord-005453-4057qib7 12839 25 ) ) -RRB- cord-005453-4057qib7 12839 26 . . . cord-005453-4057qib7 12840 1 CD34 CD34 NNP cord-005453-4057qib7 12840 2 + + CC cord-005453-4057qib7 12840 3 cell cell NN cord-005453-4057qib7 12840 4 number number NN cord-005453-4057qib7 12840 5 or or CC cord-005453-4057qib7 12840 6 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12840 7 pretreatment pretreatment NN cord-005453-4057qib7 12840 8 had have VBD cord-005453-4057qib7 12840 9 no no DT cord-005453-4057qib7 12840 10 relationship relationship NN cord-005453-4057qib7 12840 11 to to IN cord-005453-4057qib7 12840 12 non non JJ cord-005453-4057qib7 12840 13 - - JJ cord-005453-4057qib7 12840 14 infectious infectious JJ cord-005453-4057qib7 12840 15 fever fever NN cord-005453-4057qib7 12840 16 . . . cord-005453-4057qib7 12841 1 The the DT cord-005453-4057qib7 12841 2 recovery recovery NN cord-005453-4057qib7 12841 3 of of IN cord-005453-4057qib7 12841 4 lymphocytes lymphocyte NNS cord-005453-4057qib7 12841 5 was be VBD cord-005453-4057qib7 12841 6 more more RBR cord-005453-4057qib7 12841 7 rapid rapid JJ cord-005453-4057qib7 12841 8 in in IN cord-005453-4057qib7 12841 9 plerixafor plerixafor NN cord-005453-4057qib7 12841 10 - - HYPH cord-005453-4057qib7 12841 11 mobilized mobilize VBN cord-005453-4057qib7 12841 12 patients patient NNS cord-005453-4057qib7 12841 13 ( ( -LRB- cord-005453-4057qib7 12841 14 P=0.001 P=0.001 NNP cord-005453-4057qib7 12841 15 ) ) -RRB- cord-005453-4057qib7 12841 16 . . . cord-005453-4057qib7 12842 1 However however RB cord-005453-4057qib7 12842 2 , , , cord-005453-4057qib7 12842 3 the the DT cord-005453-4057qib7 12842 4 number number NN cord-005453-4057qib7 12842 5 of of IN cord-005453-4057qib7 12842 6 lymphocytes lymphocyte NNS cord-005453-4057qib7 12842 7 was be VBD cord-005453-4057qib7 12842 8 not not RB cord-005453-4057qib7 12842 9 associated associate VBN cord-005453-4057qib7 12842 10 with with IN cord-005453-4057qib7 12842 11 non non JJ cord-005453-4057qib7 12842 12 - - JJ cord-005453-4057qib7 12842 13 infectious infectious JJ cord-005453-4057qib7 12842 14 fever fever NN cord-005453-4057qib7 12842 15 . . . cord-005453-4057qib7 12843 1 Conclusions conclusion NNS cord-005453-4057qib7 12843 2 : : : cord-005453-4057qib7 12844 1 Combination combination NN cord-005453-4057qib7 12844 2 of of IN cord-005453-4057qib7 12844 3 filgrastim filgrastim NN cord-005453-4057qib7 12844 4 and and CC cord-005453-4057qib7 12844 5 plerixafor plerixafor NN cord-005453-4057qib7 12844 6 as as IN cord-005453-4057qib7 12844 7 mobilization mobilization NN cord-005453-4057qib7 12844 8 therapy therapy NN cord-005453-4057qib7 12844 9 resulted result VBD cord-005453-4057qib7 12844 10 in in IN cord-005453-4057qib7 12844 11 an an DT cord-005453-4057qib7 12844 12 increased increase VBN cord-005453-4057qib7 12844 13 risk risk NN cord-005453-4057qib7 12844 14 of of IN cord-005453-4057qib7 12844 15 noninfectious noninfectious JJ cord-005453-4057qib7 12844 16 fever fever NN cord-005453-4057qib7 12844 17 during during IN cord-005453-4057qib7 12844 18 engraftment engraftment NN cord-005453-4057qib7 12844 19 comparing compare VBG cord-005453-4057qib7 12844 20 to to IN cord-005453-4057qib7 12844 21 mobilization mobilization NN cord-005453-4057qib7 12844 22 with with IN cord-005453-4057qib7 12844 23 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12844 24 and and CC cord-005453-4057qib7 12844 25 filgrastim filgrastim NN cord-005453-4057qib7 12844 26 . . . cord-005453-4057qib7 12845 1 While while IN cord-005453-4057qib7 12845 2 the the DT cord-005453-4057qib7 12845 3 mechanism mechanism NN cord-005453-4057qib7 12845 4 remains remain VBZ cord-005453-4057qib7 12845 5 unclear unclear JJ cord-005453-4057qib7 12845 6 and and CC cord-005453-4057qib7 12845 7 requires require VBZ cord-005453-4057qib7 12845 8 further further JJ cord-005453-4057qib7 12845 9 studies study NNS cord-005453-4057qib7 12845 10 , , , cord-005453-4057qib7 12845 11 plerixafor plerixafor NN cord-005453-4057qib7 12845 12 - - HYPH cord-005453-4057qib7 12845 13 mobilized mobilize VBN cord-005453-4057qib7 12845 14 grafts graft NNS cord-005453-4057qib7 12845 15 may may MD cord-005453-4057qib7 12845 16 result result VB cord-005453-4057qib7 12845 17 in in IN cord-005453-4057qib7 12845 18 an an DT cord-005453-4057qib7 12845 19 unintended unintended JJ cord-005453-4057qib7 12845 20 increase increase NN cord-005453-4057qib7 12845 21 in in IN cord-005453-4057qib7 12845 22 engraftment engraftment NN cord-005453-4057qib7 12845 23 fever fever NN cord-005453-4057qib7 12845 24 . . . cord-005453-4057qib7 12846 1 Clinicians clinician NNS cord-005453-4057qib7 12846 2 should should MD cord-005453-4057qib7 12846 3 be be VB cord-005453-4057qib7 12846 4 aware aware JJ cord-005453-4057qib7 12846 5 of of IN cord-005453-4057qib7 12846 6 this this DT cord-005453-4057qib7 12846 7 possibility possibility NN cord-005453-4057qib7 12846 8 if if IN cord-005453-4057qib7 12846 9 patients patient NNS cord-005453-4057qib7 12846 10 are be VBP cord-005453-4057qib7 12846 11 transplanted transplant VBN cord-005453-4057qib7 12846 12 with with IN cord-005453-4057qib7 12846 13 those those DT cord-005453-4057qib7 12846 14 grafts graft NNS cord-005453-4057qib7 12846 15 . . . cord-005453-4057qib7 12847 1 Disclosure disclosure NN cord-005453-4057qib7 12847 2 : : : cord-005453-4057qib7 12847 3 KS KS NNP cord-005453-4057qib7 12847 4 received receive VBD cord-005453-4057qib7 12847 5 honorarium honorarium NN cord-005453-4057qib7 12847 6 outside outside IN cord-005453-4057qib7 12847 7 the the DT cord-005453-4057qib7 12847 8 submitted submit VBN cord-005453-4057qib7 12847 9 work work NN cord-005453-4057qib7 12847 10 from from IN cord-005453-4057qib7 12847 11 Janssen Janssen NNP cord-005453-4057qib7 12847 12 , , , cord-005453-4057qib7 12847 13 Novartis Novartis NNP cord-005453-4057qib7 12847 14 , , , cord-005453-4057qib7 12847 15 Celgene Celgene NNP cord-005453-4057qib7 12847 16 , , , cord-005453-4057qib7 12847 17 Ono Ono NNP cord-005453-4057qib7 12847 18 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 12847 19 , , , cord-005453-4057qib7 12847 20 Takeda Takeda NNP cord-005453-4057qib7 12847 21 , , , cord-005453-4057qib7 12847 22 Fujimoto Fujimoto NNP cord-005453-4057qib7 12847 23 Pharmaceuticals Pharmaceuticals NNP cord-005453-4057qib7 12847 24 and and CC cord-005453-4057qib7 12847 25 SRL SRL NNP cord-005453-4057qib7 12847 26 . . . cord-005453-4057qib7 12848 1 TI TI NNP cord-005453-4057qib7 12848 2 received receive VBD cord-005453-4057qib7 12848 3 honorarium honorarium NN cord-005453-4057qib7 12848 4 outside outside IN cord-005453-4057qib7 12848 5 the the DT cord-005453-4057qib7 12848 6 submitted submit VBN cord-005453-4057qib7 12848 7 work work NN cord-005453-4057qib7 12848 8 from from IN cord-005453-4057qib7 12848 9 Janssen Janssen NNP cord-005453-4057qib7 12848 10 , , , cord-005453-4057qib7 12848 11 Celgene Celgene NNP cord-005453-4057qib7 12848 12 , , , cord-005453-4057qib7 12848 13 Ono Ono NNP cord-005453-4057qib7 12848 14 Pharmaceuticals Pharmaceuticals NNPS cord-005453-4057qib7 12848 15 and and CC cord-005453-4057qib7 12848 16 Takeda Takeda NNP cord-005453-4057qib7 12848 17 . . . cord-005453-4057qib7 12848 18 _SP cord-005453-4057qib7 12849 1 We -PRON- PRP cord-005453-4057qib7 12849 2 assessed assess VBD cord-005453-4057qib7 12849 3 the the DT cord-005453-4057qib7 12849 4 efficacy efficacy NN cord-005453-4057qib7 12849 5 of of IN cord-005453-4057qib7 12849 6 a a DT cord-005453-4057qib7 12849 7 new new JJ cord-005453-4057qib7 12849 8 conditioning conditioning NN cord-005453-4057qib7 12849 9 regimen regimen NN cord-005453-4057qib7 12849 10 consisted consist VBN cord-005453-4057qib7 12849 11 of of IN cord-005453-4057qib7 12849 12 Decitabine Decitabine NNP cord-005453-4057qib7 12849 13 ( ( -LRB- cord-005453-4057qib7 12849 14 Dec Dec NNP cord-005453-4057qib7 12849 15 ) ) -RRB- cord-005453-4057qib7 12849 16 , , , cord-005453-4057qib7 12849 17 Busulfan Busulfan NNP cord-005453-4057qib7 12849 18 ( ( -LRB- cord-005453-4057qib7 12849 19 Bu Bu NNP cord-005453-4057qib7 12849 20 ) ) -RRB- cord-005453-4057qib7 12849 21 , , , cord-005453-4057qib7 12849 22 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 12849 23 ( ( -LRB- cord-005453-4057qib7 12849 24 Cy Cy NNP cord-005453-4057qib7 12849 25 ) ) -RRB- cord-005453-4057qib7 12849 26 , , , cord-005453-4057qib7 12849 27 Fludarabine Fludarabine NNP cord-005453-4057qib7 12849 28 ( ( -LRB- cord-005453-4057qib7 12849 29 Flud Flud NNP cord-005453-4057qib7 12849 30 ) ) -RRB- cord-005453-4057qib7 12849 31 and and CC cord-005453-4057qib7 12849 32 cytarabine cytarabine NNP cord-005453-4057qib7 12849 33 ( ( -LRB- cord-005453-4057qib7 12849 34 Ara Ara NNP cord-005453-4057qib7 12849 35 - - HYPH cord-005453-4057qib7 12849 36 c c NNP cord-005453-4057qib7 12849 37 ) ) -RRB- cord-005453-4057qib7 12849 38 for for IN cord-005453-4057qib7 12849 39 allo allo NN cord-005453-4057qib7 12849 40 - - HYPH cord-005453-4057qib7 12849 41 HSCT HSCT NNP cord-005453-4057qib7 12849 42 in in IN cord-005453-4057qib7 12849 43 patients patient NNS cord-005453-4057qib7 12849 44 with with IN cord-005453-4057qib7 12849 45 MDS MDS NNP cord-005453-4057qib7 12849 46 and and CC cord-005453-4057qib7 12849 47 MDS/ MDS/ NNP cord-005453-4057qib7 12849 48 MPN MPN NNP cord-005453-4057qib7 12849 49 . . . cord-005453-4057qib7 12850 1 Fifty fifty CD cord-005453-4057qib7 12850 2 patients patient NNS cord-005453-4057qib7 12850 3 were be VBD cord-005453-4057qib7 12850 4 enrolled enrol VBN cord-005453-4057qib7 12850 5 , , , cord-005453-4057qib7 12850 6 including include VBG cord-005453-4057qib7 12850 7 46 46 CD cord-005453-4057qib7 12850 8 with with IN cord-005453-4057qib7 12850 9 MDS MDS NNP cord-005453-4057qib7 12850 10 and and CC cord-005453-4057qib7 12850 11 4 4 CD cord-005453-4057qib7 12850 12 with with IN cord-005453-4057qib7 12850 13 CMML CMML NNP cord-005453-4057qib7 12850 14 . . . cord-005453-4057qib7 12851 1 Patients patient NNS cord-005453-4057qib7 12851 2 received receive VBD cord-005453-4057qib7 12851 3 Dec Dec NNP cord-005453-4057qib7 12851 4 20 20 CD cord-005453-4057qib7 12851 5 mg mg NNP cord-005453-4057qib7 12851 6 / / SYM cord-005453-4057qib7 12851 7 m m NN cord-005453-4057qib7 12851 8 2 2 CD cord-005453-4057qib7 12851 9 /day /day CD cord-005453-4057qib7 12851 10 on on IN cord-005453-4057qib7 12851 11 days day NNS cord-005453-4057qib7 12851 12 -9 -9 ADD cord-005453-4057qib7 12851 13 to to IN cord-005453-4057qib7 12851 14 -5 -5 NNP cord-005453-4057qib7 12851 15 , , , cord-005453-4057qib7 12851 16 combining combine VBG cord-005453-4057qib7 12851 17 Bu Bu NNP cord-005453-4057qib7 12851 18 / / SYM cord-005453-4057qib7 12851 19 Cy/ cy/ JJ cord-005453-4057qib7 12851 20 Flu/ Flu/ NNP cord-005453-4057qib7 12851 21 Ara Ara NNP cord-005453-4057qib7 12851 22 - - HYPH cord-005453-4057qib7 12851 23 c c NNP cord-005453-4057qib7 12851 24 modified modify VBD cord-005453-4057qib7 12851 25 preparative preparative JJ cord-005453-4057qib7 12851 26 regimen regimen NN cord-005453-4057qib7 12851 27 . . . cord-005453-4057qib7 12852 1 Results result NNS cord-005453-4057qib7 12852 2 : : : cord-005453-4057qib7 12853 1 At at IN cord-005453-4057qib7 12853 2 a a DT cord-005453-4057qib7 12853 3 median median JJ cord-005453-4057qib7 12853 4 follow follow NN cord-005453-4057qib7 12853 5 - - HYPH cord-005453-4057qib7 12853 6 up up NN cord-005453-4057qib7 12853 7 of of IN cord-005453-4057qib7 12853 8 522 522 CD cord-005453-4057qib7 12853 9 ( ( -LRB- cord-005453-4057qib7 12853 10 15 15 CD cord-005453-4057qib7 12853 11 - - SYM cord-005453-4057qib7 12853 12 1313 1313 CD cord-005453-4057qib7 12853 13 ) ) -RRB- cord-005453-4057qib7 12853 14 days day NNS cord-005453-4057qib7 12853 15 , , , cord-005453-4057qib7 12853 16 the the DT cord-005453-4057qib7 12853 17 overall overall JJ cord-005453-4057qib7 12853 18 survival survival NN cord-005453-4057qib7 12853 19 ( ( -LRB- cord-005453-4057qib7 12853 20 OS OS NNP cord-005453-4057qib7 12853 21 ) ) -RRB- cord-005453-4057qib7 12853 22 was be VBD cord-005453-4057qib7 12853 23 86 86 CD cord-005453-4057qib7 12853 24 % % NN cord-005453-4057qib7 12853 25 , , , cord-005453-4057qib7 12853 26 disease disease NN cord-005453-4057qib7 12853 27 - - HYPH cord-005453-4057qib7 12853 28 free free JJ cord-005453-4057qib7 12853 29 survival survival NN cord-005453-4057qib7 12853 30 ( ( -LRB- cord-005453-4057qib7 12853 31 DFS DFS NNP cord-005453-4057qib7 12853 32 ) ) -RRB- cord-005453-4057qib7 12853 33 was be VBD cord-005453-4057qib7 12853 34 78 78 CD cord-005453-4057qib7 12853 35 % % NN cord-005453-4057qib7 12853 36 , , , cord-005453-4057qib7 12853 37 and and CC cord-005453-4057qib7 12853 38 relapse relapse NN cord-005453-4057qib7 12853 39 incidence incidence NN cord-005453-4057qib7 12853 40 was be VBD cord-005453-4057qib7 12853 41 11 11 CD cord-005453-4057qib7 12853 42 % % NN cord-005453-4057qib7 12853 43 . . . cord-005453-4057qib7 12854 1 The the DT cord-005453-4057qib7 12854 2 incidence incidence NN cord-005453-4057qib7 12854 3 of of IN cord-005453-4057qib7 12854 4 severe severe JJ cord-005453-4057qib7 12854 5 acute acute JJ cord-005453-4057qib7 12854 6 ( ( -LRB- cord-005453-4057qib7 12854 7 grade grade NN cord-005453-4057qib7 12854 8 III III NNP cord-005453-4057qib7 12854 9 / / SYM cord-005453-4057qib7 12854 10 IV IV NNP cord-005453-4057qib7 12854 11 ) ) -RRB- cord-005453-4057qib7 12854 12 graft graft NN cord-005453-4057qib7 12854 13 - - HYPH cord-005453-4057qib7 12854 14 versus versus IN cord-005453-4057qib7 12854 15 - - HYPH cord-005453-4057qib7 12854 16 host host NN cord-005453-4057qib7 12854 17 disease disease NN cord-005453-4057qib7 12854 18 ( ( -LRB- cord-005453-4057qib7 12854 19 GVHD GVHD NNP cord-005453-4057qib7 12854 20 ) ) -RRB- cord-005453-4057qib7 12854 21 was be VBD cord-005453-4057qib7 12854 22 22 22 CD cord-005453-4057qib7 12854 23 % % NN cord-005453-4057qib7 12854 24 , , , cord-005453-4057qib7 12854 25 and and CC cord-005453-4057qib7 12854 26 that that DT cord-005453-4057qib7 12854 27 of of IN cord-005453-4057qib7 12854 28 ( ( -LRB- cord-005453-4057qib7 12854 29 predominantly predominantly RB cord-005453-4057qib7 12854 30 mild mild JJ cord-005453-4057qib7 12854 31 ) ) -RRB- cord-005453-4057qib7 12854 32 chronic chronic JJ cord-005453-4057qib7 12854 33 GVHD GVHD NNP cord-005453-4057qib7 12854 34 was be VBD cord-005453-4057qib7 12854 35 40 40 CD cord-005453-4057qib7 12854 36 % % NN cord-005453-4057qib7 12854 37 . . . cord-005453-4057qib7 12855 1 OS OS NNP cord-005453-4057qib7 12855 2 at at IN cord-005453-4057qib7 12855 3 2 2 CD cord-005453-4057qib7 12855 4 years year NNS cord-005453-4057qib7 12855 5 was be VBD cord-005453-4057qib7 12855 6 74 74 CD cord-005453-4057qib7 12855 7 % % NN cord-005453-4057qib7 12855 8 for for IN cord-005453-4057qib7 12855 9 MDS MDS NNP cord-005453-4057qib7 12855 10 patients patient NNS cord-005453-4057qib7 12855 11 with with IN cord-005453-4057qib7 12855 12 high high JJ cord-005453-4057qib7 12855 13 risk risk NN cord-005453-4057qib7 12855 14 , , , cord-005453-4057qib7 12855 15 86 86 CD cord-005453-4057qib7 12855 16 % % NN cord-005453-4057qib7 12855 17 for for IN cord-005453-4057qib7 12855 18 MDS MDS NNP cord-005453-4057qib7 12855 19 patients patient NNS cord-005453-4057qib7 12855 20 with with IN cord-005453-4057qib7 12855 21 very very RB cord-005453-4057qib7 12855 22 high high JJ cord-005453-4057qib7 12855 23 risk risk NN cord-005453-4057qib7 12855 24 , , , cord-005453-4057qib7 12855 25 respectively respectively RB cord-005453-4057qib7 12855 26 . . . cord-005453-4057qib7 12856 1 The the DT cord-005453-4057qib7 12856 2 survival survival NN cord-005453-4057qib7 12856 3 was be VBD cord-005453-4057qib7 12856 4 delightful delightful JJ cord-005453-4057qib7 12856 5 in in IN cord-005453-4057qib7 12856 6 patients patient NNS cord-005453-4057qib7 12856 7 with with IN cord-005453-4057qib7 12856 8 poor poor JJ cord-005453-4057qib7 12856 9 - - HYPH cord-005453-4057qib7 12856 10 risk risk NN cord-005453-4057qib7 12856 11 mutations mutation NNS cord-005453-4057qib7 12856 12 , , , cord-005453-4057qib7 12856 13 such such JJ cord-005453-4057qib7 12856 14 as as IN cord-005453-4057qib7 12856 15 TP53 TP53 NNP cord-005453-4057qib7 12856 16 and and CC cord-005453-4057qib7 12856 17 ASXL1 ASXL1 NNP cord-005453-4057qib7 12856 18 , , , cord-005453-4057qib7 12856 19 ( ( -LRB- cord-005453-4057qib7 12856 20 86 86 CD cord-005453-4057qib7 12856 21 % % NN cord-005453-4057qib7 12856 22 ) ) -RRB- cord-005453-4057qib7 12856 23 and and CC cord-005453-4057qib7 12856 24 with with IN cord-005453-4057qib7 12856 25 three three CD cord-005453-4057qib7 12856 26 or or CC cord-005453-4057qib7 12856 27 more more JJR cord-005453-4057qib7 12856 28 gene gene NN cord-005453-4057qib7 12856 29 mutations mutation NNS cord-005453-4057qib7 12856 30 ( ( -LRB- cord-005453-4057qib7 12856 31 77 77 CD cord-005453-4057qib7 12856 32 % % NN cord-005453-4057qib7 12856 33 ) ) -RRB- cord-005453-4057qib7 12856 34 . . . cord-005453-4057qib7 12857 1 Among among IN cord-005453-4057qib7 12857 2 the the DT cord-005453-4057qib7 12857 3 total total JJ cord-005453-4057qib7 12857 4 12 12 CD cord-005453-4057qib7 12857 5 patients patient NNS cord-005453-4057qib7 12857 6 with with IN cord-005453-4057qib7 12857 7 poor poor JJ cord-005453-4057qib7 12857 8 - - HYPH cord-005453-4057qib7 12857 9 risk risk NN cord-005453-4057qib7 12857 10 mutations mutation NNS cord-005453-4057qib7 12857 11 in in IN cord-005453-4057qib7 12857 12 our -PRON- PRP$ cord-005453-4057qib7 12857 13 research research NN cord-005453-4057qib7 12857 14 , , , cord-005453-4057qib7 12857 15 only only RB cord-005453-4057qib7 12857 16 one one CD cord-005453-4057qib7 12857 17 patient patient NN cord-005453-4057qib7 12857 18 ( ( -LRB- cord-005453-4057qib7 12857 19 8 8 CD cord-005453-4057qib7 12857 20 % % NN cord-005453-4057qib7 12857 21 ) ) -RRB- cord-005453-4057qib7 12857 22 with with IN cord-005453-4057qib7 12857 23 TP53 TP53 NNP cord-005453-4057qib7 12857 24 relapsed relapse VBN cord-005453-4057qib7 12857 25 and and CC cord-005453-4057qib7 12857 26 one one CD cord-005453-4057qib7 12857 27 ( ( -LRB- cord-005453-4057qib7 12857 28 8 8 CD cord-005453-4057qib7 12857 29 % % NN cord-005453-4057qib7 12857 30 ) ) -RRB- cord-005453-4057qib7 12857 31 with with IN cord-005453-4057qib7 12857 32 ASXL1and ASXL1and NNP cord-005453-4057qib7 12857 33 TET2 TET2 NNP cord-005453-4057qib7 12857 34 died die VBD cord-005453-4057qib7 12857 35 . . . cord-005453-4057qib7 12858 1 Result result NN cord-005453-4057qib7 12858 2 of of IN cord-005453-4057qib7 12858 3 continuous continuous JJ cord-005453-4057qib7 12858 4 observation observation NN cord-005453-4057qib7 12858 5 after after IN cord-005453-4057qib7 12858 6 transplantation transplantation NN cord-005453-4057qib7 12858 7 , , , cord-005453-4057qib7 12858 8 the the DT cord-005453-4057qib7 12858 9 percentage percentage NN cord-005453-4057qib7 12858 10 of of IN cord-005453-4057qib7 12858 11 NK NK NNP cord-005453-4057qib7 12858 12 cells cell NNS cord-005453-4057qib7 12858 13 in in IN cord-005453-4057qib7 12858 14 the the DT cord-005453-4057qib7 12858 15 peripheral peripheral JJ cord-005453-4057qib7 12858 16 blood blood NN cord-005453-4057qib7 12858 17 of of IN cord-005453-4057qib7 12858 18 all all DT cord-005453-4057qib7 12858 19 patients patient NNS cord-005453-4057qib7 12858 20 who who WP cord-005453-4057qib7 12858 21 had have VBD cord-005453-4057qib7 12858 22 received receive VBN cord-005453-4057qib7 12858 23 Dec Dec NNP cord-005453-4057qib7 12858 24 / / SYM cord-005453-4057qib7 12858 25 Flu Flu NNP cord-005453-4057qib7 12858 26 / / SYM cord-005453-4057qib7 12858 27 Bu Bu NNP cord-005453-4057qib7 12858 28 / / SYM cord-005453-4057qib7 12858 29 CY CY NNP cord-005453-4057qib7 12858 30 / / SYM cord-005453-4057qib7 12858 31 Ara Ara NNP cord-005453-4057qib7 12858 32 - - HYPH cord-005453-4057qib7 12858 33 c c NNP cord-005453-4057qib7 12858 34 conditioning conditioning NN cord-005453-4057qib7 12858 35 increased increase VBD cord-005453-4057qib7 12858 36 at at IN cord-005453-4057qib7 12858 37 day day NN cord-005453-4057qib7 12858 38 28 28 CD cord-005453-4057qib7 12858 39 , , , cord-005453-4057qib7 12858 40 which which WDT cord-005453-4057qib7 12858 41 may may MD cord-005453-4057qib7 12858 42 essentially essentially RB cord-005453-4057qib7 12858 43 contribute contribute VB cord-005453-4057qib7 12858 44 to to IN cord-005453-4057qib7 12858 45 disease disease NNP cord-005453-4057qib7 12858 46 control control NN cord-005453-4057qib7 12858 47 post post NN cord-005453-4057qib7 12858 48 - - NN cord-005453-4057qib7 12858 49 transplantation transplantation NN cord-005453-4057qib7 12858 50 . . . cord-005453-4057qib7 12859 1 Conclusions conclusion NNS cord-005453-4057qib7 12859 2 : : : cord-005453-4057qib7 12860 1 In in IN cord-005453-4057qib7 12860 2 summary summary NN cord-005453-4057qib7 12860 3 , , , cord-005453-4057qib7 12860 4 the the DT cord-005453-4057qib7 12860 5 addition addition NN cord-005453-4057qib7 12860 6 of of IN cord-005453-4057qib7 12860 7 a a DT cord-005453-4057qib7 12860 8 5-day 5-day JJ cord-005453-4057qib7 12860 9 schedule schedule NN cord-005453-4057qib7 12860 10 of of IN cord-005453-4057qib7 12860 11 decitabine decitabine NNP cord-005453-4057qib7 12860 12 to to IN cord-005453-4057qib7 12860 13 a a DT cord-005453-4057qib7 12860 14 Flu Flu NNP cord-005453-4057qib7 12860 15 / / SYM cord-005453-4057qib7 12860 16 Bu Bu NNP cord-005453-4057qib7 12860 17 / / SYM cord-005453-4057qib7 12860 18 CY CY NNP cord-005453-4057qib7 12860 19 / / SYM cord-005453-4057qib7 12860 20 Ara Ara NNP cord-005453-4057qib7 12860 21 - - HYPH cord-005453-4057qib7 12860 22 c c NNP cord-005453-4057qib7 12860 23 conditioning conditioning NN cord-005453-4057qib7 12860 24 regimen regimen NN cord-005453-4057qib7 12860 25 has have VBZ cord-005453-4057qib7 12860 26 proven prove VBN cord-005453-4057qib7 12860 27 feasible feasible JJ cord-005453-4057qib7 12860 28 , , , cord-005453-4057qib7 12860 29 with with IN cord-005453-4057qib7 12860 30 a a DT cord-005453-4057qib7 12860 31 low low JJ cord-005453-4057qib7 12860 32 level level NN cord-005453-4057qib7 12860 33 of of IN cord-005453-4057qib7 12860 34 toxicity toxicity NN cord-005453-4057qib7 12860 35 and and CC cord-005453-4057qib7 12860 36 promising promise VBG cord-005453-4057qib7 12860 37 early early JJ cord-005453-4057qib7 12860 38 disease disease NN cord-005453-4057qib7 12860 39 control control NN cord-005453-4057qib7 12860 40 especially especially RB cord-005453-4057qib7 12860 41 in in IN cord-005453-4057qib7 12860 42 patients patient NNS cord-005453-4057qib7 12860 43 with with IN cord-005453-4057qib7 12860 44 high high JJ cord-005453-4057qib7 12860 45 risk risk NN cord-005453-4057qib7 12860 46 MDS MDS NNP cord-005453-4057qib7 12860 47 . . . cord-005453-4057qib7 12861 1 Disclosure disclosure NN cord-005453-4057qib7 12861 2 : : : cord-005453-4057qib7 12861 3 There there EX cord-005453-4057qib7 12861 4 are be VBP cord-005453-4057qib7 12861 5 no no DT cord-005453-4057qib7 12861 6 conflicts conflict NNS cord-005453-4057qib7 12861 7 of of IN cord-005453-4057qib7 12861 8 interest interest NN cord-005453-4057qib7 12861 9 . . . cord-005453-4057qib7 12862 1 The the DT cord-005453-4057qib7 12862 2 SFGM SFGM NNP cord-005453-4057qib7 12862 3 - - HYPH cord-005453-4057qib7 12862 4 TC TC NNP cord-005453-4057qib7 12862 5 MDS MDS NNP cord-005453-4057qib7 12862 6 score score NN cord-005453-4057qib7 12862 7 at at IN cord-005453-4057qib7 12862 8 day day NN cord-005453-4057qib7 12862 9 180 180 CD cord-005453-4057qib7 12862 10 is be VBZ cord-005453-4057qib7 12862 11 associated associate VBN cord-005453-4057qib7 12862 12 with with IN cord-005453-4057qib7 12862 13 post post JJ cord-005453-4057qib7 12862 14 - - JJ cord-005453-4057qib7 12862 15 transplant transplant JJ cord-005453-4057qib7 12862 16 outcomes outcome NNS cord-005453-4057qib7 12862 17 in in IN cord-005453-4057qib7 12862 18 patients patient NNS cord-005453-4057qib7 12862 19 with with IN cord-005453-4057qib7 12862 20 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 12862 21 syndrome syndrome NN cord-005453-4057qib7 12862 22 who who WP cord-005453-4057qib7 12862 23 underwent undergo VBD cord-005453-4057qib7 12862 24 CD34 CD34 NNP cord-005453-4057qib7 12862 25 + + SYM cord-005453-4057qib7 12862 26 selected select VBN cord-005453-4057qib7 12862 27 allogeneic allogeneic JJ cord-005453-4057qib7 12862 28 stem stem NN cord-005453-4057qib7 12862 29 cell cell NN cord-005453-4057qib7 12862 30 transplant transplant NN cord-005453-4057qib7 12862 31 Conclusions conclusion NNS cord-005453-4057qib7 12862 32 : : : cord-005453-4057qib7 12863 1 In in IN cord-005453-4057qib7 12863 2 patients patient NNS cord-005453-4057qib7 12863 3 with with IN cord-005453-4057qib7 12863 4 MDS MDS NNP cord-005453-4057qib7 12863 5 undergoing undergo VBG cord-005453-4057qib7 12863 6 TCD TCD NNP cord-005453-4057qib7 12863 7 - - HYPH cord-005453-4057qib7 12863 8 HCT HCT NNP cord-005453-4057qib7 12863 9 , , , cord-005453-4057qib7 12863 10 the the DT cord-005453-4057qib7 12863 11 SFGM SFGM NNP cord-005453-4057qib7 12863 12 - - HYPH cord-005453-4057qib7 12863 13 TC TC NNP cord-005453-4057qib7 12863 14 score score NN cord-005453-4057qib7 12863 15 at at IN cord-005453-4057qib7 12863 16 day day NN cord-005453-4057qib7 12863 17 180 180 CD cord-005453-4057qib7 12863 18 is be VBZ cord-005453-4057qib7 12863 19 significantly significantly RB cord-005453-4057qib7 12863 20 associated associate VBN cord-005453-4057qib7 12863 21 with with IN cord-005453-4057qib7 12863 22 survival survival NN cord-005453-4057qib7 12863 23 . . . cord-005453-4057qib7 12864 1 The the DT cord-005453-4057qib7 12864 2 lower low JJR cord-005453-4057qib7 12864 3 incidence incidence NN cord-005453-4057qib7 12864 4 of of IN cord-005453-4057qib7 12864 5 acute acute JJ cord-005453-4057qib7 12864 6 GVHD GVHD NNP cord-005453-4057qib7 12864 7 in in IN cord-005453-4057qib7 12864 8 recipients recipient NNS cord-005453-4057qib7 12864 9 of of IN cord-005453-4057qib7 12864 10 CD34-selected cd34-selected CD cord-005453-4057qib7 12864 11 transplants transplant NNS cord-005453-4057qib7 12864 12 and and CC cord-005453-4057qib7 12864 13 the the DT cord-005453-4057qib7 12864 14 use use NN cord-005453-4057qib7 12864 15 of of IN cord-005453-4057qib7 12864 16 myeloablative myeloablative JJ cord-005453-4057qib7 12864 17 condition condition NN cord-005453-4057qib7 12864 18 regimens regimen NNS cord-005453-4057qib7 12864 19 , , , cord-005453-4057qib7 12864 20 with with IN cord-005453-4057qib7 12864 21 lower low JJR cord-005453-4057qib7 12864 22 relapse relapse NN cord-005453-4057qib7 12864 23 , , , cord-005453-4057qib7 12864 24 may may MD cord-005453-4057qib7 12864 25 explain explain VB cord-005453-4057qib7 12864 26 the the DT cord-005453-4057qib7 12864 27 difference difference NN cord-005453-4057qib7 12864 28 with with IN cord-005453-4057qib7 12864 29 the the DT cord-005453-4057qib7 12864 30 original original JJ cord-005453-4057qib7 12864 31 finding finding NN cord-005453-4057qib7 12864 32 that that IN cord-005453-4057qib7 12864 33 the the DT cord-005453-4057qib7 12864 34 SFGM SFGM NNP cord-005453-4057qib7 12864 35 - - HYPH cord-005453-4057qib7 12864 36 TC TC NNP cord-005453-4057qib7 12864 37 was be VBD cord-005453-4057qib7 12864 38 predictive predictive JJ cord-005453-4057qib7 12864 39 at at IN cord-005453-4057qib7 12864 40 day day NN cord-005453-4057qib7 12864 41 100 100 CD cord-005453-4057qib7 12864 42 in in IN cord-005453-4057qib7 12864 43 unmodified unmodified JJ cord-005453-4057qib7 12864 44 grafts graft NNS cord-005453-4057qib7 12864 45 . . . cord-005453-4057qib7 12865 1 Disclosure disclosure NN cord-005453-4057qib7 12865 2 The the DT cord-005453-4057qib7 12865 3 most most RBS cord-005453-4057qib7 12865 4 frequent frequent JJ cord-005453-4057qib7 12865 5 grade grade NN cord-005453-4057qib7 12865 6 3 3 CD cord-005453-4057qib7 12865 7 , , , cord-005453-4057qib7 12865 8 4 4 CD cord-005453-4057qib7 12865 9 toxicities toxicity NNS cord-005453-4057qib7 12865 10 were be VBD cord-005453-4057qib7 12865 11 thromobocytopenia thromobocytopenia NNS cord-005453-4057qib7 12865 12 and and CC cord-005453-4057qib7 12865 13 neutropenia neutropenia NN cord-005453-4057qib7 12865 14 . . . cord-005453-4057qib7 12866 1 Infections infection NNS cord-005453-4057qib7 12866 2 developed develop VBN cord-005453-4057qib7 12866 3 in in IN cord-005453-4057qib7 12866 4 12 12 CD cord-005453-4057qib7 12866 5 patients patient NNS cord-005453-4057qib7 12866 6 ( ( -LRB- cord-005453-4057qib7 12866 7 33.3 33.3 CD cord-005453-4057qib7 12866 8 % % NN cord-005453-4057qib7 12866 9 ) ) -RRB- cord-005453-4057qib7 12866 10 , , , cord-005453-4057qib7 12866 11 neutropenic neutropenic JJ cord-005453-4057qib7 12866 12 fever fever NN cord-005453-4057qib7 12866 13 in in IN cord-005453-4057qib7 12866 14 8 8 CD cord-005453-4057qib7 12866 15 ( ( -LRB- cord-005453-4057qib7 12866 16 19.4 19.4 CD cord-005453-4057qib7 12866 17 % % NN cord-005453-4057qib7 12866 18 ) ) -RRB- cord-005453-4057qib7 12866 19 . . . cord-005453-4057qib7 12867 1 Five five CD cord-005453-4057qib7 12867 2 patients patient NNS cord-005453-4057qib7 12867 3 ( ( -LRB- cord-005453-4057qib7 12867 4 13.9 13.9 CD cord-005453-4057qib7 12867 5 % % NN cord-005453-4057qib7 12867 6 ) ) -RRB- cord-005453-4057qib7 12867 7 either either CC cord-005453-4057qib7 12867 8 developed develop VBN cord-005453-4057qib7 12867 9 or or CC cord-005453-4057qib7 12867 10 experienced experienced JJ cord-005453-4057qib7 12867 11 exacerbation exacerbation NN cord-005453-4057qib7 12867 12 of of IN cord-005453-4057qib7 12867 13 acute acute JJ cord-005453-4057qib7 12867 14 graft graft NN cord-005453-4057qib7 12867 15 versus versus IN cord-005453-4057qib7 12867 16 host host NN cord-005453-4057qib7 12867 17 disease disease NN cord-005453-4057qib7 12867 18 ( ( -LRB- cord-005453-4057qib7 12867 19 GVHD GVHD NNP cord-005453-4057qib7 12867 20 ) ) -RRB- cord-005453-4057qib7 12867 21 , , , cord-005453-4057qib7 12867 22 nonechronic nonechronic NNP cord-005453-4057qib7 12867 23 GVHD GVHD NNP cord-005453-4057qib7 12867 24 . . . cord-005453-4057qib7 12868 1 Conclusions conclusion NNS cord-005453-4057qib7 12868 2 : : : cord-005453-4057qib7 12869 1 Azacitidine azacitidine JJ cord-005453-4057qib7 12869 2 use use NN cord-005453-4057qib7 12869 3 is be VBZ cord-005453-4057qib7 12869 4 associated associate VBN cord-005453-4057qib7 12869 5 with with IN cord-005453-4057qib7 12869 6 only only JJ cord-005453-4057qib7 12869 7 modest modest JJ cord-005453-4057qib7 12869 8 activity activity NN cord-005453-4057qib7 12869 9 in in IN cord-005453-4057qib7 12869 10 patients patient NNS cord-005453-4057qib7 12869 11 who who WP cord-005453-4057qib7 12869 12 relapse relapse VBP cord-005453-4057qib7 12869 13 after after IN cord-005453-4057qib7 12869 14 allo allo NN cord-005453-4057qib7 12869 15 - - HYPH cord-005453-4057qib7 12869 16 HSCT HSCT NNP cord-005453-4057qib7 12869 17 . . . cord-005453-4057qib7 12870 1 However however RB cord-005453-4057qib7 12870 2 , , , cord-005453-4057qib7 12870 3 in in IN cord-005453-4057qib7 12870 4 patients patient NNS cord-005453-4057qib7 12870 5 who who WP cord-005453-4057qib7 12870 6 respond respond VBP cord-005453-4057qib7 12870 7 to to IN cord-005453-4057qib7 12870 8 treatment treatment NN cord-005453-4057qib7 12870 9 it -PRON- PRP cord-005453-4057qib7 12870 10 may may MD cord-005453-4057qib7 12870 11 allow allow VB cord-005453-4057qib7 12870 12 for for IN cord-005453-4057qib7 12870 13 a a DT cord-005453-4057qib7 12870 14 durable durable JJ cord-005453-4057qib7 12870 15 disease disease NN cord-005453-4057qib7 12870 16 control control NN cord-005453-4057qib7 12870 17 . . . cord-005453-4057qib7 12871 1 Disclosure disclosure NN cord-005453-4057qib7 12871 2 : : : cord-005453-4057qib7 12872 1 The the DT cord-005453-4057qib7 12872 2 authors author NNS cord-005453-4057qib7 12872 3 declare declare VBP cord-005453-4057qib7 12872 4 no no DT cord-005453-4057qib7 12872 5 competing compete VBG cord-005453-4057qib7 12872 6 conflicts conflict NNS cord-005453-4057qib7 12872 7 of of IN cord-005453-4057qib7 12872 8 interest interest NN cord-005453-4057qib7 12872 9 Background background NN cord-005453-4057qib7 12872 10 : : : cord-005453-4057qib7 12872 11 Somatic somatic JJ cord-005453-4057qib7 12872 12 mutations mutation NNS cord-005453-4057qib7 12872 13 in in IN cord-005453-4057qib7 12872 14 MDS MDS NNP cord-005453-4057qib7 12872 15 patients patient NNS cord-005453-4057qib7 12872 16 are be VBP cord-005453-4057qib7 12872 17 closely closely RB cord-005453-4057qib7 12872 18 related relate VBN cord-005453-4057qib7 12872 19 with with IN cord-005453-4057qib7 12872 20 clinical clinical JJ cord-005453-4057qib7 12872 21 phenotypes phenotype NNS cord-005453-4057qib7 12872 22 and and CC cord-005453-4057qib7 12872 23 prognosis prognosis NN cord-005453-4057qib7 12872 24 in in IN cord-005453-4057qib7 12872 25 MDS MDS NNP cord-005453-4057qib7 12872 26 patients patient NNS cord-005453-4057qib7 12872 27 . . . cord-005453-4057qib7 12873 1 But but CC cord-005453-4057qib7 12873 2 whether whether IN cord-005453-4057qib7 12873 3 mutations mutation NNS cord-005453-4057qib7 12873 4 are be VBP cord-005453-4057qib7 12873 5 prognostic prognostic JJ cord-005453-4057qib7 12873 6 for for IN cord-005453-4057qib7 12873 7 outcomes outcome NNS cord-005453-4057qib7 12873 8 after after IN cord-005453-4057qib7 12873 9 allogeneic allogeneic JJ cord-005453-4057qib7 12873 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 12873 11 stem stem NN cord-005453-4057qib7 12873 12 - - HYPH cord-005453-4057qib7 12873 13 cell cell NN cord-005453-4057qib7 12873 14 transplantation transplantation NN cord-005453-4057qib7 12873 15 ( ( -LRB- cord-005453-4057qib7 12873 16 allo allo NN cord-005453-4057qib7 12873 17 - - HYPH cord-005453-4057qib7 12873 18 HSCT HSCT NNP cord-005453-4057qib7 12873 19 ) ) -RRB- cord-005453-4057qib7 12873 20 remains remain VBZ cord-005453-4057qib7 12873 21 to to TO cord-005453-4057qib7 12873 22 be be VB cord-005453-4057qib7 12873 23 elaborated elaborate VBN cord-005453-4057qib7 12873 24 . . . cord-005453-4057qib7 12874 1 Methods method NNS cord-005453-4057qib7 12874 2 : : : cord-005453-4057qib7 12874 3 Targeted target VBN cord-005453-4057qib7 12874 4 mutational mutational JJ cord-005453-4057qib7 12874 5 analysis analysis NN cord-005453-4057qib7 12874 6 were be VBD cord-005453-4057qib7 12874 7 performed perform VBN cord-005453-4057qib7 12874 8 on on IN cord-005453-4057qib7 12874 9 samples sample NNS cord-005453-4057qib7 12874 10 obtained obtain VBN cord-005453-4057qib7 12874 11 before before IN cord-005453-4057qib7 12874 12 transplantation transplantation NN cord-005453-4057qib7 12874 13 from from IN cord-005453-4057qib7 12874 14 134 134 CD cord-005453-4057qib7 12874 15 patients patient NNS cord-005453-4057qib7 12874 16 underwent undergo VBD cord-005453-4057qib7 12874 17 HSCT HSCT NNP cord-005453-4057qib7 12874 18 . . . cord-005453-4057qib7 12875 1 We -PRON- PRP cord-005453-4057qib7 12875 2 analyzed analyze VBD cord-005453-4057qib7 12875 3 the the DT cord-005453-4057qib7 12875 4 relationship relationship NN cord-005453-4057qib7 12875 5 of of IN cord-005453-4057qib7 12875 6 mutations mutation NNS cord-005453-4057qib7 12875 7 and and CC cord-005453-4057qib7 12875 8 clinical clinical JJ cord-005453-4057qib7 12875 9 outcomes outcome NNS cord-005453-4057qib7 12875 10 . . . cord-005453-4057qib7 12876 1 Results result NNS cord-005453-4057qib7 12876 2 : : : cord-005453-4057qib7 12877 1 All all DT cord-005453-4057qib7 12877 2 134 134 CD cord-005453-4057qib7 12877 3 patients patient NNS cord-005453-4057qib7 12877 4 carried carry VBD cord-005453-4057qib7 12877 5 more more JJR cord-005453-4057qib7 12877 6 than than IN cord-005453-4057qib7 12877 7 one one CD cord-005453-4057qib7 12877 8 somatic somatic JJ cord-005453-4057qib7 12877 9 mutations mutation NNS cord-005453-4057qib7 12877 10 , , , cord-005453-4057qib7 12877 11 most most RBS cord-005453-4057qib7 12877 12 frequently frequently RB cord-005453-4057qib7 12877 13 in in IN cord-005453-4057qib7 12877 14 KMT2D(67.16 KMT2D(67.16 NNP cord-005453-4057qib7 12877 15 % % NN cord-005453-4057qib7 12877 16 ) ) -RRB- cord-005453-4057qib7 12877 17 , , , cord-005453-4057qib7 12877 18 ARID1B arid1b NN cord-005453-4057qib7 12877 19 ( ( -LRB- cord-005453-4057qib7 12877 20 61.94 61.94 CD cord-005453-4057qib7 12877 21 % % NN cord-005453-4057qib7 12877 22 ) ) -RRB- cord-005453-4057qib7 12877 23 , , , cord-005453-4057qib7 12877 24 CCDC168(52.24 CCDC168(52.24 NNP cord-005453-4057qib7 12877 25 % % NN cord-005453-4057qib7 12877 26 ) ) -RRB- cord-005453-4057qib7 12877 27 , , , cord-005453-4057qib7 12877 28 PCLO(47.01 pclo(47.01 NN cord-005453-4057qib7 12877 29 % % NN cord-005453-4057qib7 12877 30 ) ) -RRB- cord-005453-4057qib7 12877 31 , , , cord-005453-4057qib7 12877 32 ASXL1/2 asxl1/2 NN cord-005453-4057qib7 12877 33 ( ( -LRB- cord-005453-4057qib7 12877 34 46.27 46.27 CD cord-005453-4057qib7 12877 35 % % NN cord-005453-4057qib7 12877 36 ) ) -RRB- cord-005453-4057qib7 12877 37 , , , cord-005453-4057qib7 12877 38 SRCAP(44.78 SRCAP(44.78 NNP cord-005453-4057qib7 12877 39 % % NN cord-005453-4057qib7 12877 40 ) ) -RRB- cord-005453-4057qib7 12877 41 , , , cord-005453-4057qib7 12877 42 U2AF1(42.54 u2af1(42.54 CD cord-005453-4057qib7 12877 43 % % NN cord-005453-4057qib7 12877 44 ) ) -RRB- cord-005453-4057qib7 12877 45 , , , cord-005453-4057qib7 12877 46 DNAH2 DNAH2 NNP cord-005453-4057qib7 12877 47 ( ( -LRB- cord-005453-4057qib7 12877 48 41.79 41.79 CD cord-005453-4057qib7 12877 49 % % NN cord-005453-4057qib7 12877 50 ) ) -RRB- cord-005453-4057qib7 12877 51 , , , cord-005453-4057qib7 12877 52 USH2A(41.04 ush2a(41.04 NN cord-005453-4057qib7 12877 53 % % NN cord-005453-4057qib7 12877 54 ) ) -RRB- cord-005453-4057qib7 12877 55 and and CC cord-005453-4057qib7 12877 56 TET2(34.33 TET2(34.33 NNS cord-005453-4057qib7 12877 57 % % NN cord-005453-4057qib7 12877 58 ) ) -RRB- cord-005453-4057qib7 12877 59 . . . cord-005453-4057qib7 12878 1 TP53 TP53 NNP cord-005453-4057qib7 12878 2 mutations mutation NNS cord-005453-4057qib7 12878 3 were be VBD cord-005453-4057qib7 12878 4 associated associate VBN cord-005453-4057qib7 12878 5 with with IN cord-005453-4057qib7 12878 6 higher high JJR cord-005453-4057qib7 12878 7 IPSS IPSS NNP cord-005453-4057qib7 12878 8 - - HYPH cord-005453-4057qib7 12878 9 R r NN cord-005453-4057qib7 12878 10 risk risk NN cord-005453-4057qib7 12878 11 , , , cord-005453-4057qib7 12878 12 complex complex JJ cord-005453-4057qib7 12878 13 karyotype karyotype NN cord-005453-4057qib7 12878 14 and and CC cord-005453-4057qib7 12878 15 monosomal monosomal JJ cord-005453-4057qib7 12878 16 karyotype karyotype NN cord-005453-4057qib7 12878 17 . . . cord-005453-4057qib7 12879 1 DNAH2 DNAH2 NNP cord-005453-4057qib7 12879 2 were be VBD cord-005453-4057qib7 12879 3 more more RBR cord-005453-4057qib7 12879 4 frequent frequent JJ cord-005453-4057qib7 12879 5 in in IN cord-005453-4057qib7 12879 6 pediatric pediatric JJ cord-005453-4057qib7 12879 7 patients patient NNS cord-005453-4057qib7 12879 8 . . . cord-005453-4057qib7 12880 1 In in IN cord-005453-4057qib7 12880 2 univariable univariable JJ cord-005453-4057qib7 12880 3 analyses analysis NNS cord-005453-4057qib7 12880 4 , , , cord-005453-4057qib7 12880 5 TP53 TP53 NNP cord-005453-4057qib7 12880 6 mutations mutation NNS cord-005453-4057qib7 12880 7 were be VBD cord-005453-4057qib7 12880 8 related relate VBN cord-005453-4057qib7 12880 9 with with IN cord-005453-4057qib7 12880 10 decreased decreased JJ cord-005453-4057qib7 12880 11 disease disease NN cord-005453-4057qib7 12880 12 - - HYPH cord-005453-4057qib7 12880 13 free free JJ cord-005453-4057qib7 12880 14 survival survival NN cord-005453-4057qib7 12880 15 ( ( -LRB- cord-005453-4057qib7 12880 16 P=0.047 P=0.047 NNS cord-005453-4057qib7 12880 17 ) ) -RRB- cord-005453-4057qib7 12880 18 ; ; : cord-005453-4057qib7 12880 19 DNAH2 dnah2 NN cord-005453-4057qib7 12880 20 mutations mutation NNS cord-005453-4057qib7 12880 21 were be VBD cord-005453-4057qib7 12880 22 related relate VBN cord-005453-4057qib7 12880 23 with with IN cord-005453-4057qib7 12880 24 increased increase VBN cord-005453-4057qib7 12880 25 disease disease NN cord-005453-4057qib7 12880 26 - - HYPH cord-005453-4057qib7 12880 27 free free JJ cord-005453-4057qib7 12880 28 survival survival NN cord-005453-4057qib7 12880 29 ( ( -LRB- cord-005453-4057qib7 12880 30 DFS DFS NNP cord-005453-4057qib7 12880 31 ) ) -RRB- cord-005453-4057qib7 12880 32 ( ( -LRB- cord-005453-4057qib7 12880 33 P=0.038 P=0.038 NNP cord-005453-4057qib7 12880 34 ) ) -RRB- cord-005453-4057qib7 12880 35 . . . cord-005453-4057qib7 12881 1 In in IN cord-005453-4057qib7 12881 2 multivariable multivariable JJ cord-005453-4057qib7 12881 3 analysis analysis NN cord-005453-4057qib7 12881 4 including include VBG cord-005453-4057qib7 12881 5 IPSS IPSS NNP cord-005453-4057qib7 12881 6 - - HYPH cord-005453-4057qib7 12881 7 R r NN cord-005453-4057qib7 12881 8 stratification stratification NN cord-005453-4057qib7 12881 9 , , , cord-005453-4057qib7 12881 10 GVHD GVHD NNP cord-005453-4057qib7 12881 11 , , , cord-005453-4057qib7 12881 12 HCT HCT NNP cord-005453-4057qib7 12881 13 - - HYPH cord-005453-4057qib7 12881 14 CI ci NN cord-005453-4057qib7 12881 15 and and CC cord-005453-4057qib7 12881 16 candidate candidate NN cord-005453-4057qib7 12881 17 genes gene NNS cord-005453-4057qib7 12881 18 , , , cord-005453-4057qib7 12881 19 DNAH2 dnah2 NN cord-005453-4057qib7 12881 20 mutations mutation NNS cord-005453-4057qib7 12881 21 were be VBD cord-005453-4057qib7 12881 22 independently independently RB cord-005453-4057qib7 12881 23 associated associate VBN cord-005453-4057qib7 12881 24 with with IN cord-005453-4057qib7 12881 25 better well JJR cord-005453-4057qib7 12881 26 DFS(P=0.027 dfs(p=0.027 ADD cord-005453-4057qib7 12881 27 ) ) -RRB- cord-005453-4057qib7 12881 28 . . . cord-005453-4057qib7 12882 1 Conclusions conclusion NNS cord-005453-4057qib7 12882 2 : : : cord-005453-4057qib7 12883 1 DNAH2 DNAH2 NNP cord-005453-4057qib7 12884 1 mutations mutation NNS cord-005453-4057qib7 12884 2 is be VBZ cord-005453-4057qib7 12884 3 independently independently RB cord-005453-4057qib7 12884 4 associated associate VBN cord-005453-4057qib7 12884 5 with with IN cord-005453-4057qib7 12884 6 better well JJR cord-005453-4057qib7 12884 7 outcomes outcome NNS cord-005453-4057qib7 12884 8 in in IN cord-005453-4057qib7 12884 9 MDS MDS NNP cord-005453-4057qib7 12884 10 patients patient NNS cord-005453-4057qib7 12884 11 treated treat VBN cord-005453-4057qib7 12884 12 with with IN cord-005453-4057qib7 12884 13 allo allo NN cord-005453-4057qib7 12884 14 - - HYPH cord-005453-4057qib7 12884 15 HSCT HSCT NNP cord-005453-4057qib7 12884 16 while while IN cord-005453-4057qib7 12884 17 TP53 TP53 NNP cord-005453-4057qib7 12884 18 may may MD cord-005453-4057qib7 12884 19 predict predict VB cord-005453-4057qib7 12884 20 unfavorable unfavorable JJ cord-005453-4057qib7 12884 21 outcomes outcome NNS cord-005453-4057qib7 12884 22 . . . cord-005453-4057qib7 12885 1 Accounting account VBG cord-005453-4057qib7 12885 2 for for IN cord-005453-4057qib7 12885 3 these these DT cord-005453-4057qib7 12885 4 somatic somatic JJ cord-005453-4057qib7 12885 5 mutations mutation NNS cord-005453-4057qib7 12885 6 may may MD cord-005453-4057qib7 12885 7 help help VB cord-005453-4057qib7 12885 8 better well JJR cord-005453-4057qib7 12885 9 selection selection NN cord-005453-4057qib7 12885 10 of of IN cord-005453-4057qib7 12885 11 candidates candidate NNS cord-005453-4057qib7 12885 12 for for IN cord-005453-4057qib7 12885 13 allo allo NN cord-005453-4057qib7 12885 14 - - HYPH cord-005453-4057qib7 12885 15 HSCT HSCT NNP cord-005453-4057qib7 12885 16 among among IN cord-005453-4057qib7 12885 17 MDS MDS NNP cord-005453-4057qib7 12885 18 patients patient NNS cord-005453-4057qib7 12885 19 . . . cord-005453-4057qib7 12886 1 Disclosure disclosure NN cord-005453-4057qib7 12886 2 Background background NN cord-005453-4057qib7 12886 3 : : : cord-005453-4057qib7 12886 4 There there EX cord-005453-4057qib7 12886 5 is be VBZ cord-005453-4057qib7 12886 6 a a DT cord-005453-4057qib7 12886 7 controversy controversy NN cord-005453-4057qib7 12886 8 among among IN cord-005453-4057qib7 12886 9 experts expert NNS cord-005453-4057qib7 12886 10 if if IN cord-005453-4057qib7 12886 11 and and CC cord-005453-4057qib7 12886 12 how how WRB cord-005453-4057qib7 12886 13 patients patient NNS cord-005453-4057qib7 12886 14 with with IN cord-005453-4057qib7 12886 15 MDS MDS NNP cord-005453-4057qib7 12886 16 and and CC cord-005453-4057qib7 12886 17 sAML saml NN cord-005453-4057qib7 12886 18 should should MD cord-005453-4057qib7 12886 19 receive receive VB cord-005453-4057qib7 12886 20 cytoreductive cytoreductive JJ cord-005453-4057qib7 12886 21 therapy therapy NN cord-005453-4057qib7 12886 22 before before IN cord-005453-4057qib7 12886 23 transplant transplant NN cord-005453-4057qib7 12886 24 . . . cord-005453-4057qib7 12887 1 While while IN cord-005453-4057qib7 12887 2 aiming aim VBG cord-005453-4057qib7 12887 3 to to TO cord-005453-4057qib7 12887 4 reduce reduce VB cord-005453-4057qib7 12887 5 disease disease NN cord-005453-4057qib7 12887 6 burden burden NN cord-005453-4057qib7 12887 7 in in IN cord-005453-4057qib7 12887 8 order order NN cord-005453-4057qib7 12887 9 to to TO cord-005453-4057qib7 12887 10 lower lower VB cord-005453-4057qib7 12887 11 the the DT cord-005453-4057qib7 12887 12 risk risk NN cord-005453-4057qib7 12887 13 of of IN cord-005453-4057qib7 12887 14 relapse relapse NN cord-005453-4057qib7 12887 15 after after IN cord-005453-4057qib7 12887 16 transplant transplant NN cord-005453-4057qib7 12887 17 cytoreductive cytoreductive NN cord-005453-4057qib7 12887 18 therapy therapy NN cord-005453-4057qib7 12887 19 is be VBZ cord-005453-4057qib7 12887 20 associated associate VBN cord-005453-4057qib7 12887 21 with with IN cord-005453-4057qib7 12887 22 several several JJ cord-005453-4057qib7 12887 23 drawbacks drawback NNS cord-005453-4057qib7 12887 24 . . . cord-005453-4057qib7 12888 1 Besides besides IN cord-005453-4057qib7 12888 2 a a DT cord-005453-4057qib7 12888 3 considerable considerable JJ cord-005453-4057qib7 12888 4 risk risk NN cord-005453-4057qib7 12888 5 for for IN cord-005453-4057qib7 12888 6 toxicity toxicity NN cord-005453-4057qib7 12888 7 and and CC cord-005453-4057qib7 12888 8 mortality mortality NN cord-005453-4057qib7 12888 9 preventing prevent VBG cord-005453-4057qib7 12888 10 patients patient NNS cord-005453-4057qib7 12888 11 to to TO cord-005453-4057qib7 12888 12 proceed proceed VB cord-005453-4057qib7 12888 13 to to IN cord-005453-4057qib7 12888 14 transplant transplant NN cord-005453-4057qib7 12888 15 cytoreductive cytoreductive NN cord-005453-4057qib7 12888 16 therapy therapy NN cord-005453-4057qib7 12889 1 may may MD cord-005453-4057qib7 12889 2 also also RB cord-005453-4057qib7 12889 3 favour favour VB cord-005453-4057qib7 12889 4 the the DT cord-005453-4057qib7 12889 5 selection selection NN cord-005453-4057qib7 12889 6 of of IN cord-005453-4057qib7 12889 7 resistant resistant JJ cord-005453-4057qib7 12889 8 clones clone NNS cord-005453-4057qib7 12889 9 which which WDT cord-005453-4057qib7 12889 10 may may MD cord-005453-4057qib7 12889 11 be be VB cord-005453-4057qib7 12889 12 difficult difficult JJ cord-005453-4057qib7 12889 13 to to TO cord-005453-4057qib7 12889 14 treat treat VB cord-005453-4057qib7 12889 15 at at IN cord-005453-4057qib7 12889 16 relapse relapse NN cord-005453-4057qib7 12889 17 . . . cord-005453-4057qib7 12890 1 Methods method NNS cord-005453-4057qib7 12890 2 : : : cord-005453-4057qib7 12890 3 To to TO cord-005453-4057qib7 12890 4 address address VB cord-005453-4057qib7 12890 5 this this DT cord-005453-4057qib7 12890 6 hypothesis hypothesis NN cord-005453-4057qib7 12890 7 we -PRON- PRP cord-005453-4057qib7 12890 8 retrospectively retrospectively RB cord-005453-4057qib7 12890 9 analysed analyse VBD cord-005453-4057qib7 12890 10 the the DT cord-005453-4057qib7 12890 11 response response NN cord-005453-4057qib7 12890 12 and and CC cord-005453-4057qib7 12890 13 survival survival NN cord-005453-4057qib7 12890 14 following follow VBG cord-005453-4057qib7 12890 15 salvage salvage NN cord-005453-4057qib7 12890 16 therapy therapy NN cord-005453-4057qib7 12890 17 in in IN cord-005453-4057qib7 12890 18 73 73 CD cord-005453-4057qib7 12890 19 patients patient NNS cord-005453-4057qib7 12890 20 with with IN cord-005453-4057qib7 12890 21 MDS MDS NNP cord-005453-4057qib7 12890 22 and and CC cord-005453-4057qib7 12890 23 sAML saml NN cord-005453-4057qib7 12890 24 who who WP cord-005453-4057qib7 12890 25 had have VBD cord-005453-4057qib7 12890 26 relapsed relapse VBN cord-005453-4057qib7 12890 27 in in IN cord-005453-4057qib7 12890 28 median median JJ cord-005453-4057qib7 12890 29 5.6 5.6 CD cord-005453-4057qib7 12890 30 months month NNS cord-005453-4057qib7 12890 31 ( ( -LRB- cord-005453-4057qib7 12890 32 1 1 CD cord-005453-4057qib7 12890 33 to to IN cord-005453-4057qib7 12890 34 110 110 CD cord-005453-4057qib7 12890 35 months month NNS cord-005453-4057qib7 12890 36 ) ) -RRB- cord-005453-4057qib7 12890 37 after after IN cord-005453-4057qib7 12890 38 allo allo NNP cord-005453-4057qib7 12890 39 - - HYPH cord-005453-4057qib7 12890 40 SCT SCT NNP cord-005453-4057qib7 12890 41 according accord VBG cord-005453-4057qib7 12890 42 to to IN cord-005453-4057qib7 12890 43 their -PRON- PRP$ cord-005453-4057qib7 12890 44 pre pre JJ cord-005453-4057qib7 12890 45 - - JJ cord-005453-4057qib7 12890 46 transplant transplant JJ cord-005453-4057qib7 12890 47 strategy strategy NN cord-005453-4057qib7 12890 48 ( ( -LRB- cord-005453-4057qib7 12890 49 upfront upfront NN cord-005453-4057qib7 12890 50 transplantation transplantation NN cord-005453-4057qib7 12890 51 n=32 n=32 NNP cord-005453-4057qib7 12890 52 44 44 CD cord-005453-4057qib7 12890 53 % % NN cord-005453-4057qib7 12890 54 ; ; : cord-005453-4057qib7 12890 55 induction induction NN cord-005453-4057qib7 12890 56 chemotherapy chemotherapy NN cord-005453-4057qib7 12890 57 [ [ -LRB- cord-005453-4057qib7 12890 58 CTX CTX NNP cord-005453-4057qib7 12890 59 ] ] -RRB- cord-005453-4057qib7 12890 60 n=26 n=26 RB cord-005453-4057qib7 12890 61 36 36 CD cord-005453-4057qib7 12890 62 % % NN cord-005453-4057qib7 12890 63 ; ; , cord-005453-4057qib7 12890 64 hypomethylating hypomethylate VBG cord-005453-4057qib7 12890 65 agents agent NNS cord-005453-4057qib7 12890 66 [ [ -LRB- cord-005453-4057qib7 12890 67 HMA HMA NNP cord-005453-4057qib7 12890 68 ] ] -RRB- cord-005453-4057qib7 12891 1 n=15 n=15 NNP cord-005453-4057qib7 12891 2 20 20 CD cord-005453-4057qib7 12891 3 % % NN cord-005453-4057qib7 12891 4 ) ) -RRB- cord-005453-4057qib7 12891 5 . . . cord-005453-4057qib7 12892 1 Results result NNS cord-005453-4057qib7 12892 2 : : : cord-005453-4057qib7 12893 1 The the DT cord-005453-4057qib7 12893 2 majority majority NN cord-005453-4057qib7 12893 3 of of IN cord-005453-4057qib7 12893 4 these these DT cord-005453-4057qib7 12893 5 73 73 CD cord-005453-4057qib7 12893 6 patients patient NNS cord-005453-4057qib7 12893 7 received receive VBD cord-005453-4057qib7 12893 8 salvage salvage NN cord-005453-4057qib7 12893 9 therapy therapy NN cord-005453-4057qib7 12893 10 with with IN cord-005453-4057qib7 12893 11 HMA HMA NNP cord-005453-4057qib7 12893 12 ( ( -LRB- cord-005453-4057qib7 12893 13 n=58 n=58 NN cord-005453-4057qib7 12893 14 , , , cord-005453-4057qib7 12893 15 79 79 CD cord-005453-4057qib7 12893 16 % % NN cord-005453-4057qib7 12893 17 ; ; . cord-005453-4057qib7 12894 1 Aza Aza NNP cord-005453-4057qib7 12894 2 n=57 n=57 NN cord-005453-4057qib7 12894 3 , , , cord-005453-4057qib7 12894 4 DAC DAC NNP cord-005453-4057qib7 12894 5 n=1 n=1 NNP cord-005453-4057qib7 12894 6 ) ) -RRB- cord-005453-4057qib7 12894 7 mostly mostly RB cord-005453-4057qib7 12894 8 in in IN cord-005453-4057qib7 12894 9 combination combination NN cord-005453-4057qib7 12894 10 with with IN cord-005453-4057qib7 12894 11 DLI DLI NNP cord-005453-4057qib7 12894 12 , , , cord-005453-4057qib7 12894 13 while while IN cord-005453-4057qib7 12894 14 the the DT cord-005453-4057qib7 12894 15 remaining remain VBG cord-005453-4057qib7 12894 16 received receive VBN cord-005453-4057qib7 12894 17 other other JJ cord-005453-4057qib7 12894 18 salvage salvage NN cord-005453-4057qib7 12894 19 treatments treatment NNS cord-005453-4057qib7 12894 20 ( ( -LRB- cord-005453-4057qib7 12894 21 intensive intensive JJ cord-005453-4057qib7 12894 22 chemotherapy chemotherapy NN cord-005453-4057qib7 12894 23 n=1 n=1 RB cord-005453-4057qib7 12894 24 , , , cord-005453-4057qib7 12894 25 DLI DLI NNP cord-005453-4057qib7 12894 26 alone alone RB cord-005453-4057qib7 12894 27 n=1 n=1 RB cord-005453-4057qib7 12894 28 , , , cord-005453-4057qib7 12894 29 2 2 CD cord-005453-4057qib7 12894 30 nd nd NNP cord-005453-4057qib7 12894 31 transplant transplant NN cord-005453-4057qib7 12894 32 n=3 n=3 NN cord-005453-4057qib7 12894 33 , , , cord-005453-4057qib7 12894 34 BSC BSC NNP cord-005453-4057qib7 12894 35 n=5 n=5 RB cord-005453-4057qib7 12894 36 , , , cord-005453-4057qib7 12894 37 miscellaneous miscellaneous JJ cord-005453-4057qib7 12894 38 n=2 n=2 NNS cord-005453-4057qib7 12894 39 , , , cord-005453-4057qib7 12894 40 missing miss VBG cord-005453-4057qib7 12894 41 information information NN cord-005453-4057qib7 12894 42 n=3 n=3 NN cord-005453-4057qib7 12894 43 ) ) -RRB- cord-005453-4057qib7 12894 44 . . . cord-005453-4057qib7 12895 1 When when WRB cord-005453-4057qib7 12895 2 focussing focusse VBG cord-005453-4057qib7 12895 3 on on IN cord-005453-4057qib7 12895 4 those those DT cord-005453-4057qib7 12895 5 patients patient NNS cord-005453-4057qib7 12895 6 treated treat VBN cord-005453-4057qib7 12895 7 with with IN cord-005453-4057qib7 12895 8 HMA HMA NNP cord-005453-4057qib7 12895 9 and and CC cord-005453-4057qib7 12895 10 DLI DLI NNP cord-005453-4057qib7 12896 1 it -PRON- PRP cord-005453-4057qib7 12896 2 became become VBD cord-005453-4057qib7 12896 3 apparent apparent JJ cord-005453-4057qib7 12896 4 that that IN cord-005453-4057qib7 12896 5 a a DT cord-005453-4057qib7 12896 6 significantly significantly RB cord-005453-4057qib7 12896 7 higher high JJR cord-005453-4057qib7 12896 8 proportion proportion NN cord-005453-4057qib7 12896 9 of of IN cord-005453-4057qib7 12896 10 patients patient NNS cord-005453-4057qib7 12896 11 in in IN cord-005453-4057qib7 12896 12 the the DT cord-005453-4057qib7 12896 13 upfront upfront JJ cord-005453-4057qib7 12896 14 group group NN cord-005453-4057qib7 12896 15 ( ( -LRB- cord-005453-4057qib7 12896 16 58 58 CD cord-005453-4057qib7 12896 17 % % NN cord-005453-4057qib7 12896 18 ) ) -RRB- cord-005453-4057qib7 12896 19 achieved achieve VBD cord-005453-4057qib7 12896 20 CR cr NN cord-005453-4057qib7 12896 21 after after IN cord-005453-4057qib7 12896 22 salvage salvage NN cord-005453-4057qib7 12896 23 therapy therapy NN cord-005453-4057qib7 12896 24 in in IN cord-005453-4057qib7 12896 25 comparison comparison NN cord-005453-4057qib7 12896 26 to to TO cord-005453-4057qib7 12896 27 pre pre VB cord-005453-4057qib7 12896 28 - - JJ cord-005453-4057qib7 12896 29 treated treat VBN cord-005453-4057qib7 12896 30 patients patient NNS cord-005453-4057qib7 12896 31 ( ( -LRB- cord-005453-4057qib7 12896 32 10 10 CD cord-005453-4057qib7 12896 33 % % NN cord-005453-4057qib7 12896 34 CR cr NN cord-005453-4057qib7 12896 35 , , , cord-005453-4057qib7 12896 36 p=0.0005 p=0.0005 NNP cord-005453-4057qib7 12896 37 ; ; : cord-005453-4057qib7 12896 38 CTX CTX NNP cord-005453-4057qib7 12896 39 group group NN cord-005453-4057qib7 12896 40 5 5 CD cord-005453-4057qib7 12896 41 % % NN cord-005453-4057qib7 12896 42 CR CR NNP cord-005453-4057qib7 12896 43 ; ; : cord-005453-4057qib7 12896 44 HMA HMA NNP cord-005453-4057qib7 12896 45 group group NN cord-005453-4057qib7 12896 46 18 18 CD cord-005453-4057qib7 12896 47 % % NN cord-005453-4057qib7 12896 48 CR cr NN cord-005453-4057qib7 12896 49 ) ) -RRB- cord-005453-4057qib7 12896 50 . . . cord-005453-4057qib7 12897 1 Accordingly accordingly RB cord-005453-4057qib7 12897 2 , , , cord-005453-4057qib7 12897 3 overall overall JJ cord-005453-4057qib7 12897 4 survival survival NN cord-005453-4057qib7 12897 5 ( ( -LRB- cord-005453-4057qib7 12897 6 OS OS NNP cord-005453-4057qib7 12897 7 ) ) -RRB- cord-005453-4057qib7 12897 8 calculated calculate VBD cord-005453-4057qib7 12897 9 from from IN cord-005453-4057qib7 12897 10 the the DT cord-005453-4057qib7 12897 11 time time NN cord-005453-4057qib7 12897 12 of of IN cord-005453-4057qib7 12897 13 relapse relapse NN cord-005453-4057qib7 12897 14 was be VBD cord-005453-4057qib7 12897 15 significantly significantly RB cord-005453-4057qib7 12897 16 longer long JJR cord-005453-4057qib7 12897 17 in in IN cord-005453-4057qib7 12897 18 patients patient NNS cord-005453-4057qib7 12897 19 in in IN cord-005453-4057qib7 12897 20 the the DT cord-005453-4057qib7 12897 21 upfront upfront JJ cord-005453-4057qib7 12897 22 group group NN cord-005453-4057qib7 12897 23 than than IN cord-005453-4057qib7 12897 24 in in IN cord-005453-4057qib7 12897 25 the the DT cord-005453-4057qib7 12897 26 group group NN cord-005453-4057qib7 12897 27 of of IN cord-005453-4057qib7 12897 28 pre pre JJ cord-005453-4057qib7 12897 29 - - JJ cord-005453-4057qib7 12897 30 treated treat VBN cord-005453-4057qib7 12897 31 patients patient NNS cord-005453-4057qib7 12897 32 ( ( -LRB- cord-005453-4057qib7 12897 33 2-year 2-year CD cord-005453-4057qib7 12897 34 OS OS NNP cord-005453-4057qib7 12897 35 59 59 CD cord-005453-4057qib7 12897 36 % % NN cord-005453-4057qib7 12897 37 vs. vs. IN cord-005453-4057qib7 12897 38 19 19 CD cord-005453-4057qib7 12897 39 % % NN cord-005453-4057qib7 12897 40 , , , cord-005453-4057qib7 12897 41 p=0.0001 p=0.0001 NNP cord-005453-4057qib7 12897 42 ) ) -RRB- cord-005453-4057qib7 12897 43 . . . cord-005453-4057qib7 12898 1 Conclusions conclusion NNS cord-005453-4057qib7 12898 2 : : : cord-005453-4057qib7 12899 1 Overall overall RB cord-005453-4057qib7 12899 2 , , , cord-005453-4057qib7 12899 3 these these DT cord-005453-4057qib7 12899 4 findings finding NNS cord-005453-4057qib7 12899 5 imply imply VBP cord-005453-4057qib7 12899 6 that that IN cord-005453-4057qib7 12899 7 pretransplant pretransplant NN cord-005453-4057qib7 12899 8 therapy therapy NN cord-005453-4057qib7 12899 9 may may MD cord-005453-4057qib7 12899 10 favour favour VB cord-005453-4057qib7 12899 11 the the DT cord-005453-4057qib7 12899 12 iatrogenic iatrogenic JJ cord-005453-4057qib7 12899 13 selection selection NN cord-005453-4057qib7 12899 14 of of IN cord-005453-4057qib7 12899 15 resistant resistant JJ cord-005453-4057qib7 12899 16 clones clone NNS cord-005453-4057qib7 12899 17 , , , cord-005453-4057qib7 12899 18 which which WDT cord-005453-4057qib7 12899 19 poorly poorly RB cord-005453-4057qib7 12899 20 respond respond VBP cord-005453-4057qib7 12899 21 to to TO cord-005453-4057qib7 12899 22 salvage salvage VB cord-005453-4057qib7 12899 23 therapy therapy NN cord-005453-4057qib7 12899 24 with with IN cord-005453-4057qib7 12899 25 HMA HMA NNP cord-005453-4057qib7 12899 26 and and CC cord-005453-4057qib7 12899 27 DLI DLI NNP cord-005453-4057qib7 12899 28 in in IN cord-005453-4057qib7 12899 29 case case NN cord-005453-4057qib7 12899 30 of of IN cord-005453-4057qib7 12899 31 relapse relapse NN cord-005453-4057qib7 12899 32 after after IN cord-005453-4057qib7 12899 33 allo allo NN cord-005453-4057qib7 12899 34 - - HYPH cord-005453-4057qib7 12899 35 SCT SCT NNP cord-005453-4057qib7 12899 36 . . . cord-005453-4057qib7 12900 1 Furthermore furthermore RB cord-005453-4057qib7 12900 2 , , , cord-005453-4057qib7 12900 3 the the DT cord-005453-4057qib7 12900 4 results result NNS cord-005453-4057qib7 12900 5 support support VBP cord-005453-4057qib7 12900 6 the the DT cord-005453-4057qib7 12900 7 concept concept NN cord-005453-4057qib7 12900 8 that that IN cord-005453-4057qib7 12900 9 an an DT cord-005453-4057qib7 12900 10 upfront upfront JJ cord-005453-4057qib7 12900 11 transplant transplant NN cord-005453-4057qib7 12900 12 strategy strategy NN cord-005453-4057qib7 12900 13 is be VBZ cord-005453-4057qib7 12900 14 a a DT cord-005453-4057qib7 12900 15 promising promising JJ cord-005453-4057qib7 12900 16 alternative alternative NN cord-005453-4057qib7 12900 17 for for IN cord-005453-4057qib7 12900 18 patients patient NNS cord-005453-4057qib7 12900 19 with with IN cord-005453-4057qib7 12900 20 MDS MDS NNP cord-005453-4057qib7 12900 21 and and CC cord-005453-4057qib7 12900 22 sAML saml NN cord-005453-4057qib7 12900 23 that that WDT cord-005453-4057qib7 12900 24 can can MD cord-005453-4057qib7 12900 25 be be VB cord-005453-4057qib7 12900 26 augmented augment VBN cord-005453-4057qib7 12900 27 by by IN cord-005453-4057qib7 12900 28 salvage salvage NN cord-005453-4057qib7 12900 29 therapy therapy NN cord-005453-4057qib7 12900 30 with with IN cord-005453-4057qib7 12900 31 HMA HMA NNP cord-005453-4057qib7 12900 32 and and CC cord-005453-4057qib7 12900 33 DLI DLI NNP cord-005453-4057qib7 12900 34 . . . cord-005453-4057qib7 12901 1 Disclosure disclosure NN cord-005453-4057qib7 12901 2 : : : cord-005453-4057qib7 12902 1 TS TS NNP cord-005453-4057qib7 12902 2 and and CC cord-005453-4057qib7 12902 3 GK GK NNP cord-005453-4057qib7 12902 4 received receive VBD cord-005453-4057qib7 12902 5 travel travel NN cord-005453-4057qib7 12902 6 support support NN cord-005453-4057qib7 12902 7 , , , cord-005453-4057qib7 12902 8 lecture lecture NN cord-005453-4057qib7 12902 9 fees fee NNS cord-005453-4057qib7 12902 10 and and CC cord-005453-4057qib7 12902 11 research research NN cord-005453-4057qib7 12902 12 funding funding NN cord-005453-4057qib7 12902 13 from from IN cord-005453-4057qib7 12902 14 Celgene Celgene NNP cord-005453-4057qib7 12902 15 GmbH GmbH NNP cord-005453-4057qib7 12902 16 Conclusions conclusion NNS cord-005453-4057qib7 12902 17 : : : cord-005453-4057qib7 12903 1 In in IN cord-005453-4057qib7 12903 2 our -PRON- PRP$ cord-005453-4057qib7 12903 3 country country NN cord-005453-4057qib7 12903 4 , , , cord-005453-4057qib7 12903 5 this this DT cord-005453-4057qib7 12903 6 procedure procedure NN cord-005453-4057qib7 12903 7 has have VBZ cord-005453-4057qib7 12903 8 shown show VBN cord-005453-4057qib7 12903 9 to to TO cord-005453-4057qib7 12903 10 be be VB cord-005453-4057qib7 12903 11 feasible feasible JJ cord-005453-4057qib7 12903 12 and and CC cord-005453-4057qib7 12903 13 we -PRON- PRP cord-005453-4057qib7 12903 14 hope hope VBP cord-005453-4057qib7 12903 15 to to TO cord-005453-4057qib7 12903 16 improve improve VB cord-005453-4057qib7 12903 17 it -PRON- PRP cord-005453-4057qib7 12903 18 , , , cord-005453-4057qib7 12903 19 with with IN cord-005453-4057qib7 12903 20 better well JJR cord-005453-4057qib7 12903 21 infection infection NN cord-005453-4057qib7 12903 22 control control NN cord-005453-4057qib7 12903 23 and and CC cord-005453-4057qib7 12903 24 by by IN cord-005453-4057qib7 12903 25 acquiring acquire VBG cord-005453-4057qib7 12903 26 more more JJR cord-005453-4057qib7 12903 27 experience experience NN cord-005453-4057qib7 12903 28 related relate VBN cord-005453-4057qib7 12903 29 to to IN cord-005453-4057qib7 12903 30 the the DT cord-005453-4057qib7 12903 31 management management NN cord-005453-4057qib7 12903 32 of of IN cord-005453-4057qib7 12903 33 these these DT cord-005453-4057qib7 12903 34 patients patient NNS cord-005453-4057qib7 12903 35 . . . cord-005453-4057qib7 12904 1 Background background NN cord-005453-4057qib7 12904 2 : : : cord-005453-4057qib7 12905 1 Extramedullar Extramedullar NNP cord-005453-4057qib7 12905 2 relapse relapse NN cord-005453-4057qib7 12905 3 of of IN cord-005453-4057qib7 12905 4 MDS MDS NNP cord-005453-4057qib7 12905 5 is be VBZ cord-005453-4057qib7 12905 6 a a DT cord-005453-4057qib7 12905 7 rare rare JJ cord-005453-4057qib7 12905 8 complication complication NN cord-005453-4057qib7 12905 9 after after IN cord-005453-4057qib7 12905 10 allogeneic allogeneic NN cord-005453-4057qib7 12905 11 stem stem NN cord-005453-4057qib7 12905 12 cell cell NN cord-005453-4057qib7 12905 13 transplantation transplantation NN cord-005453-4057qib7 12905 14 . . . cord-005453-4057qib7 12906 1 We -PRON- PRP cord-005453-4057qib7 12906 2 present present VBP cord-005453-4057qib7 12906 3 the the DT cord-005453-4057qib7 12906 4 case case NN cord-005453-4057qib7 12906 5 of of IN cord-005453-4057qib7 12906 6 a a DT cord-005453-4057qib7 12906 7 69-year 69-year JJ cord-005453-4057qib7 12906 8 - - HYPH cord-005453-4057qib7 12906 9 old old JJ cord-005453-4057qib7 12906 10 woman woman NN cord-005453-4057qib7 12906 11 who who WP cord-005453-4057qib7 12906 12 was be VBD cord-005453-4057qib7 12906 13 admitted admit VBN cord-005453-4057qib7 12906 14 into into IN cord-005453-4057qib7 12906 15 hospital hospital NN cord-005453-4057qib7 12906 16 because because IN cord-005453-4057qib7 12906 17 of of IN cord-005453-4057qib7 12906 18 insecure insecure JJ cord-005453-4057qib7 12906 19 walking walking NN cord-005453-4057qib7 12906 20 . . . cord-005453-4057qib7 12907 1 Paresis Paresis NNP cord-005453-4057qib7 12907 2 of of IN cord-005453-4057qib7 12907 3 both both DT cord-005453-4057qib7 12907 4 legs leg NNS cord-005453-4057qib7 12907 5 , , , cord-005453-4057qib7 12907 6 hypaesthesia hypaesthesia NNP cord-005453-4057qib7 12907 7 of of IN cord-005453-4057qib7 12907 8 the the DT cord-005453-4057qib7 12907 9 inner inner JJ cord-005453-4057qib7 12907 10 thighs thigh NNS cord-005453-4057qib7 12907 11 , , , cord-005453-4057qib7 12907 12 increased increase VBN cord-005453-4057qib7 12907 13 effort effort NN cord-005453-4057qib7 12907 14 at at IN cord-005453-4057qib7 12907 15 urinating urinate VBG cord-005453-4057qib7 12907 16 , , , cord-005453-4057qib7 12907 17 reduced reduce VBN cord-005453-4057qib7 12907 18 sphincter sphincter NN cord-005453-4057qib7 12907 19 tonus tonus NN cord-005453-4057qib7 12907 20 , , , cord-005453-4057qib7 12907 21 central central JJ cord-005453-4057qib7 12907 22 paresis paresis NN cord-005453-4057qib7 12907 23 of of IN cord-005453-4057qib7 12907 24 the the DT cord-005453-4057qib7 12907 25 right right JJ cord-005453-4057qib7 12907 26 arm arm NN cord-005453-4057qib7 12907 27 and and CC cord-005453-4057qib7 12907 28 discreet discreet JJ cord-005453-4057qib7 12907 29 paresis paresis NN cord-005453-4057qib7 12907 30 of of IN cord-005453-4057qib7 12907 31 the the DT cord-005453-4057qib7 12907 32 right right JJ cord-005453-4057qib7 12907 33 facial facial JJ cord-005453-4057qib7 12907 34 nerve nerve NN cord-005453-4057qib7 12907 35 were be VBD cord-005453-4057qib7 12907 36 documented document VBN cord-005453-4057qib7 12907 37 at at IN cord-005453-4057qib7 12907 38 neurological neurological JJ cord-005453-4057qib7 12907 39 exam exam NN cord-005453-4057qib7 12907 40 . . . cord-005453-4057qib7 12908 1 MRI MRI NNP cord-005453-4057qib7 12908 2 showed show VBD cord-005453-4057qib7 12908 3 a a DT cord-005453-4057qib7 12908 4 large large JJ cord-005453-4057qib7 12908 5 tumour tumour NN cord-005453-4057qib7 12908 6 of of IN cord-005453-4057qib7 12908 7 the the DT cord-005453-4057qib7 12908 8 dorsal dorsal JJ cord-005453-4057qib7 12908 9 thorax thorax NN cord-005453-4057qib7 12908 10 that that WDT cord-005453-4057qib7 12908 11 immured immure VBD cord-005453-4057qib7 12908 12 the the DT cord-005453-4057qib7 12908 13 adjacent adjacent JJ cord-005453-4057qib7 12908 14 ribs rib NNS cord-005453-4057qib7 12908 15 and and CC cord-005453-4057qib7 12908 16 spine spine NN cord-005453-4057qib7 12908 17 , , , cord-005453-4057qib7 12908 18 affected affect VBD cord-005453-4057qib7 12908 19 the the DT cord-005453-4057qib7 12908 20 processus processus NNP cord-005453-4057qib7 12908 21 transversus transversus NN cord-005453-4057qib7 12908 22 of of IN cord-005453-4057qib7 12908 23 T9 T9 NNP cord-005453-4057qib7 12908 24 - - SYM cord-005453-4057qib7 12908 25 10 10 CD cord-005453-4057qib7 12908 26 and and CC cord-005453-4057qib7 12908 27 invaded invade VBD cord-005453-4057qib7 12908 28 the the DT cord-005453-4057qib7 12908 29 spinal spinal JJ cord-005453-4057qib7 12908 30 canal canal NN cord-005453-4057qib7 12908 31 . . . cord-005453-4057qib7 12909 1 The the DT cord-005453-4057qib7 12909 2 patient patient NN cord-005453-4057qib7 12909 3 had have VBD cord-005453-4057qib7 12909 4 undergone undergo VBN cord-005453-4057qib7 12909 5 RIC RIC NNP cord-005453-4057qib7 12909 6 allogeneic allogeneic IN cord-005453-4057qib7 12909 7 stem stem NN cord-005453-4057qib7 12909 8 cell cell NN cord-005453-4057qib7 12909 9 transplantation transplantation NN cord-005453-4057qib7 12909 10 five five CD cord-005453-4057qib7 12909 11 years year NNS cord-005453-4057qib7 12909 12 ago ago RB cord-005453-4057qib7 12909 13 for for IN cord-005453-4057qib7 12909 14 MDS MDS NNP cord-005453-4057qib7 12909 15 - - HYPH cord-005453-4057qib7 12909 16 EB EB NNP cord-005453-4057qib7 12909 17 2 2 CD cord-005453-4057qib7 12909 18 with with IN cord-005453-4057qib7 12909 19 complex complex JJ cord-005453-4057qib7 12909 20 aberrant aberrant JJ cord-005453-4057qib7 12909 21 karyotype karyotype NN cord-005453-4057qib7 12909 22 . . . cord-005453-4057qib7 12910 1 Following follow VBG cord-005453-4057qib7 12910 2 an an DT cord-005453-4057qib7 12910 3 uneventful uneventful JJ cord-005453-4057qib7 12910 4 course course NN cord-005453-4057qib7 12910 5 and and CC cord-005453-4057qib7 12910 6 no no DT cord-005453-4057qib7 12910 7 signs sign NNS cord-005453-4057qib7 12910 8 of of IN cord-005453-4057qib7 12910 9 GvHD GvHD NNP cord-005453-4057qib7 12910 10 , , , cord-005453-4057qib7 12910 11 she -PRON- PRP cord-005453-4057qib7 12910 12 had have VBD cord-005453-4057qib7 12910 13 been be VBN cord-005453-4057qib7 12910 14 off off IN cord-005453-4057qib7 12910 15 immunosuppression immunosuppression NN cord-005453-4057qib7 12910 16 since since IN cord-005453-4057qib7 12910 17 4,5 4,5 CD cord-005453-4057qib7 12910 18 years year NNS cord-005453-4057qib7 12910 19 . . . cord-005453-4057qib7 12911 1 At at IN cord-005453-4057qib7 12911 2 the the DT cord-005453-4057qib7 12911 3 time time NN cord-005453-4057qib7 12911 4 of of IN cord-005453-4057qib7 12911 5 the the DT cord-005453-4057qib7 12911 6 admission admission NN cord-005453-4057qib7 12911 7 the the DT cord-005453-4057qib7 12911 8 patient patient NN cord-005453-4057qib7 12911 9 had have VBD cord-005453-4057qib7 12911 10 slightly slightly RB cord-005453-4057qib7 12911 11 lowered lower VBN cord-005453-4057qib7 12911 12 WBC WBC NNP cord-005453-4057qib7 12911 13 ( ( -LRB- cord-005453-4057qib7 12911 14 2,9 2,9 CD cord-005453-4057qib7 12911 15 Gpt Gpt NNP cord-005453-4057qib7 12911 16 / / SYM cord-005453-4057qib7 12911 17 l l NN cord-005453-4057qib7 12911 18 ) ) -RRB- cord-005453-4057qib7 12911 19 and and CC cord-005453-4057qib7 12911 20 PLT PLT NNP cord-005453-4057qib7 12911 21 ( ( -LRB- cord-005453-4057qib7 12911 22 111 111 CD cord-005453-4057qib7 12911 23 Gpt Gpt NNP cord-005453-4057qib7 12911 24 / / SYM cord-005453-4057qib7 12911 25 l l NN cord-005453-4057qib7 12911 26 ) ) -RRB- cord-005453-4057qib7 12911 27 and and CC cord-005453-4057qib7 12911 28 clearly clearly RB cord-005453-4057qib7 12911 29 increased increase VBD cord-005453-4057qib7 12911 30 LDH LDH NNP cord-005453-4057qib7 12911 31 ( ( -LRB- cord-005453-4057qib7 12911 32 793 793 CD cord-005453-4057qib7 12911 33 U u NN cord-005453-4057qib7 12911 34 / / SYM cord-005453-4057qib7 12911 35 l l NN cord-005453-4057qib7 12911 36 ) ) -RRB- cord-005453-4057qib7 12911 37 . . . cord-005453-4057qib7 12912 1 Methods method NNS cord-005453-4057qib7 12912 2 : : : cord-005453-4057qib7 12913 1 Histology histology NN cord-005453-4057qib7 12913 2 of of IN cord-005453-4057qib7 12913 3 a a DT cord-005453-4057qib7 12913 4 CT CT NNP cord-005453-4057qib7 12913 5 - - HYPH cord-005453-4057qib7 12913 6 based base VBN cord-005453-4057qib7 12913 7 biopsy biopsy NN cord-005453-4057qib7 12913 8 of of IN cord-005453-4057qib7 12913 9 the the DT cord-005453-4057qib7 12913 10 paravertebral paravertebral JJ cord-005453-4057qib7 12913 11 tumour tumour NN cord-005453-4057qib7 12913 12 showed show VBD cord-005453-4057qib7 12913 13 an an DT cord-005453-4057qib7 12913 14 infiltration infiltration NN cord-005453-4057qib7 12913 15 of of IN cord-005453-4057qib7 12913 16 the the DT cord-005453-4057qib7 12913 17 muscles muscle NNS cord-005453-4057qib7 12913 18 by by IN cord-005453-4057qib7 12913 19 blastous blastous JJ cord-005453-4057qib7 12913 20 cells cell NNS cord-005453-4057qib7 12913 21 that that WDT cord-005453-4057qib7 12913 22 were be VBD cord-005453-4057qib7 12913 23 CD45- CD45- VBG cord-005453-4057qib7 12913 24 , , , cord-005453-4057qib7 12913 25 CD34- cd34- NN cord-005453-4057qib7 12913 26 , , , cord-005453-4057qib7 12913 27 PAX5-positive pax5-positive JJ cord-005453-4057qib7 12913 28 , , , cord-005453-4057qib7 12913 29 TdT tdt NN cord-005453-4057qib7 12913 30 and and CC cord-005453-4057qib7 12913 31 CD79a CD79a NNP cord-005453-4057qib7 12913 32 were be VBD cord-005453-4057qib7 12913 33 questionably questionably RB cord-005453-4057qib7 12913 34 positive positive JJ cord-005453-4057qib7 12913 35 . . . cord-005453-4057qib7 12914 1 Provisonal provisonal JJ cord-005453-4057qib7 12914 2 diagnosis diagnosis NN cord-005453-4057qib7 12914 3 therefore therefore RB cord-005453-4057qib7 12914 4 was be VBD cord-005453-4057qib7 12914 5 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 12914 6 lymphoma lymphoma NN cord-005453-4057qib7 12914 7 , , , cord-005453-4057qib7 12914 8 POX POX NNP cord-005453-4057qib7 12914 9 tested test VBD cord-005453-4057qib7 12914 10 negative negative JJ cord-005453-4057qib7 12914 11 . . . cord-005453-4057qib7 12915 1 The the DT cord-005453-4057qib7 12915 2 bone bone NN cord-005453-4057qib7 12915 3 marrow marrow NN cord-005453-4057qib7 12915 4 was be VBD cord-005453-4057qib7 12915 5 hypocellular hypocellular NN cord-005453-4057qib7 12915 6 with with IN cord-005453-4057qib7 12915 7 increased increase VBN cord-005453-4057qib7 12915 8 numbers number NNS cord-005453-4057qib7 12915 9 of of IN cord-005453-4057qib7 12915 10 mature mature JJ cord-005453-4057qib7 12915 11 lymphocytes lymphocyte NNS cord-005453-4057qib7 12915 12 , , , cord-005453-4057qib7 12915 13 but but CC cord-005453-4057qib7 12915 14 no no DT cord-005453-4057qib7 12915 15 definite definite JJ cord-005453-4057qib7 12915 16 signs sign NNS cord-005453-4057qib7 12915 17 of of IN cord-005453-4057qib7 12915 18 malignancy malignancy NN cord-005453-4057qib7 12915 19 . . . cord-005453-4057qib7 12916 1 Cerebrospinal cerebrospinal NN cord-005453-4057qib7 12916 2 fluid fluid NN cord-005453-4057qib7 12916 3 revealed reveal VBD cord-005453-4057qib7 12916 4 1574 1574 CD cord-005453-4057qib7 12916 5 cells cell NNS cord-005453-4057qib7 12916 6 / / SYM cord-005453-4057qib7 12916 7 μl μl VBP cord-005453-4057qib7 12916 8 with with IN cord-005453-4057qib7 12916 9 90 90 CD cord-005453-4057qib7 12916 10 % % NN cord-005453-4057qib7 12916 11 blasts blast NNS cord-005453-4057qib7 12916 12 . . . cord-005453-4057qib7 12917 1 Immunotype Immunotype NNP cord-005453-4057qib7 12917 2 was be VBD cord-005453-4057qib7 12917 3 CD34 CD34 NNP cord-005453-4057qib7 12917 4 , , , cord-005453-4057qib7 12918 1 CD117 cd117 UH cord-005453-4057qib7 12918 2 , , , cord-005453-4057qib7 12918 3 CD13 CD13 NNP cord-005453-4057qib7 12918 4 , , , cord-005453-4057qib7 12918 5 CD33 CD33 NNP cord-005453-4057qib7 12918 6 , , , cord-005453-4057qib7 12918 7 HLA HLA NNP cord-005453-4057qib7 12918 8 - - HYPH cord-005453-4057qib7 12918 9 DR DR NNP cord-005453-4057qib7 12918 10 positive positive JJ cord-005453-4057qib7 12918 11 , , , cord-005453-4057qib7 12918 12 POX pox NN cord-005453-4057qib7 12918 13 and and CC cord-005453-4057qib7 12918 14 lymphatic lymphatic JJ cord-005453-4057qib7 12918 15 markers marker NNS cord-005453-4057qib7 12918 16 were be VBD cord-005453-4057qib7 12918 17 negative negative JJ cord-005453-4057qib7 12918 18 . . . cord-005453-4057qib7 12919 1 Because because IN cord-005453-4057qib7 12919 2 of of IN cord-005453-4057qib7 12919 3 this this DT cord-005453-4057qib7 12919 4 we -PRON- PRP cord-005453-4057qib7 12919 5 finally finally RB cord-005453-4057qib7 12919 6 suspected suspect VBD cord-005453-4057qib7 12919 7 meningeosis meningeosis NNP cord-005453-4057qib7 12919 8 leucaemica leucaemica NNP cord-005453-4057qib7 12919 9 . . . cord-005453-4057qib7 12920 1 We -PRON- PRP cord-005453-4057qib7 12920 2 completed complete VBD cord-005453-4057qib7 12920 3 the the DT cord-005453-4057qib7 12920 4 diagnostic diagnostic JJ cord-005453-4057qib7 12920 5 workup workup NN cord-005453-4057qib7 12920 6 with with IN cord-005453-4057qib7 12920 7 genetical genetical JJ cord-005453-4057qib7 12920 8 and and CC cord-005453-4057qib7 12920 9 chimaerism chimaerism NN cord-005453-4057qib7 12920 10 tests test NNS cord-005453-4057qib7 12920 11 and and CC cord-005453-4057qib7 12920 12 compared compare VBD cord-005453-4057qib7 12920 13 the the DT cord-005453-4057qib7 12920 14 result result NN cord-005453-4057qib7 12920 15 to to IN cord-005453-4057qib7 12920 16 the the DT cord-005453-4057qib7 12920 17 patients patient NNS cord-005453-4057qib7 12920 18 ' ' POS cord-005453-4057qib7 12920 19 MDS mds NN cord-005453-4057qib7 12920 20 before before IN cord-005453-4057qib7 12920 21 allogeneic allogeneic NN cord-005453-4057qib7 12920 22 stem stem NN cord-005453-4057qib7 12920 23 cell cell NN cord-005453-4057qib7 12920 24 transplantation transplantation NN cord-005453-4057qib7 12920 25 . . . cord-005453-4057qib7 12921 1 [ [ -LRB- cord-005453-4057qib7 12921 2 [ [ -LRB- cord-005453-4057qib7 12921 3 P580 P580 NNP cord-005453-4057qib7 12921 4 Image image NN cord-005453-4057qib7 12921 5 ] ] -RRB- cord-005453-4057qib7 12921 6 1 1 CD cord-005453-4057qib7 12921 7 . . . cord-005453-4057qib7 12922 1 MRI MRI NNP cord-005453-4057qib7 12922 2 scan scan NN cord-005453-4057qib7 12922 3 of of IN cord-005453-4057qib7 12922 4 the the DT cord-005453-4057qib7 12922 5 large large JJ cord-005453-4057qib7 12922 6 thoracic thoracic JJ cord-005453-4057qib7 12922 7 tumour tumour NN cord-005453-4057qib7 12922 8 ] ] -RRB- cord-005453-4057qib7 12923 1 Results result NNS cord-005453-4057qib7 12923 2 : : : cord-005453-4057qib7 12924 1 Cerebrospinal cerebrospinal NN cord-005453-4057qib7 12924 2 fluid fluid NN cord-005453-4057qib7 12924 3 ( ( -LRB- cord-005453-4057qib7 12924 4 CSF CSF NNP cord-005453-4057qib7 12924 5 ) ) -RRB- cord-005453-4057qib7 12924 6 cells cell NNS cord-005453-4057qib7 12924 7 consisted consist VBD cord-005453-4057qib7 12924 8 of of IN cord-005453-4057qib7 12924 9 92 92 CD cord-005453-4057qib7 12924 10 % % NN cord-005453-4057qib7 12924 11 recipient recipient NN cord-005453-4057qib7 12924 12 cells cell NNS cord-005453-4057qib7 12924 13 , , , cord-005453-4057qib7 12924 14 whereas whereas IN cord-005453-4057qib7 12924 15 peripheral peripheral JJ cord-005453-4057qib7 12924 16 blood blood NN cord-005453-4057qib7 12924 17 cells cell NNS cord-005453-4057qib7 12924 18 were be VBD cord-005453-4057qib7 12924 19 100 100 CD cord-005453-4057qib7 12924 20 % % NN cord-005453-4057qib7 12924 21 donor donor NN cord-005453-4057qib7 12924 22 . . . cord-005453-4057qib7 12925 1 High high JJ cord-005453-4057qib7 12925 2 risk risk NN cord-005453-4057qib7 12925 3 MDS mds NN cord-005453-4057qib7 12925 4 at at IN cord-005453-4057qib7 12925 5 transplant transplant NN cord-005453-4057qib7 12925 6 displayed display VBD cord-005453-4057qib7 12925 7 a a DT cord-005453-4057qib7 12925 8 complex complex JJ cord-005453-4057qib7 12925 9 caryotype caryotype NN cord-005453-4057qib7 12925 10 including include VBG cord-005453-4057qib7 12925 11 trisomy trisomy NN cord-005453-4057qib7 12925 12 8 8 CD cord-005453-4057qib7 12925 13 and and CC cord-005453-4057qib7 12925 14 tetrasomy tetrasomy NNP cord-005453-4057qib7 12925 15 8 8 CD cord-005453-4057qib7 12925 16 , , , cord-005453-4057qib7 12925 17 now now RB cord-005453-4057qib7 12925 18 10 10 CD cord-005453-4057qib7 12925 19 % % NN cord-005453-4057qib7 12925 20 of of IN cord-005453-4057qib7 12925 21 the the DT cord-005453-4057qib7 12925 22 cells cell NNS cord-005453-4057qib7 12925 23 in in IN cord-005453-4057qib7 12925 24 CSF CSF NNP cord-005453-4057qib7 12925 25 showed show VBD cord-005453-4057qib7 12925 26 trisomy trisomy NN cord-005453-4057qib7 12925 27 8 8 CD cord-005453-4057qib7 12925 28 and and CC cord-005453-4057qib7 12925 29 70 70 CD cord-005453-4057qib7 12925 30 % % NN cord-005453-4057qib7 12925 31 tetrasomy tetrasomy NN cord-005453-4057qib7 12925 32 8 8 CD cord-005453-4057qib7 12925 33 . . . cord-005453-4057qib7 12926 1 Chimerism chimerism NN cord-005453-4057qib7 12926 2 and and CC cord-005453-4057qib7 12926 3 FISH fish NN cord-005453-4057qib7 12926 4 of of IN cord-005453-4057qib7 12926 5 the the DT cord-005453-4057qib7 12926 6 solid solid JJ cord-005453-4057qib7 12926 7 tumour tumour NN cord-005453-4057qib7 12926 8 could could MD cord-005453-4057qib7 12926 9 not not RB cord-005453-4057qib7 12926 10 be be VB cord-005453-4057qib7 12926 11 performed perform VBN cord-005453-4057qib7 12926 12 , , , cord-005453-4057qib7 12926 13 coexpression coexpression NN cord-005453-4057qib7 12926 14 of of IN cord-005453-4057qib7 12926 15 myeloid myeloid JJ cord-005453-4057qib7 12926 16 markers marker NNS cord-005453-4057qib7 12926 17 within within IN cord-005453-4057qib7 12926 18 the the DT cord-005453-4057qib7 12926 19 tumour tumour NN cord-005453-4057qib7 12926 20 is be VBZ cord-005453-4057qib7 12926 21 pending pende VBG cord-005453-4057qib7 12926 22 . . . cord-005453-4057qib7 12927 1 Conclusions conclusion NNS cord-005453-4057qib7 12927 2 : : : cord-005453-4057qib7 12928 1 In in IN cord-005453-4057qib7 12928 2 conclusion conclusion NN cord-005453-4057qib7 12928 3 the the DT cord-005453-4057qib7 12928 4 patient patient NN cord-005453-4057qib7 12928 5 has have VBZ cord-005453-4057qib7 12928 6 meningeosis meningeosis NN cord-005453-4057qib7 12928 7 as as IN cord-005453-4057qib7 12928 8 a a DT cord-005453-4057qib7 12928 9 result result NN cord-005453-4057qib7 12928 10 of of IN cord-005453-4057qib7 12928 11 exclusively exclusively RB cord-005453-4057qib7 12928 12 extramedullary extramedullary JJ cord-005453-4057qib7 12928 13 relapse relapse NN cord-005453-4057qib7 12928 14 of of IN cord-005453-4057qib7 12928 15 myeloid myeloid NN cord-005453-4057qib7 12928 16 blasts blast NNS cord-005453-4057qib7 12928 17 originating originate VBG cord-005453-4057qib7 12928 18 from from IN cord-005453-4057qib7 12928 19 the the DT cord-005453-4057qib7 12928 20 initial initial JJ cord-005453-4057qib7 12928 21 high high JJ cord-005453-4057qib7 12928 22 risk risk NN cord-005453-4057qib7 12928 23 MDS MDS NNP cord-005453-4057qib7 12928 24 with with IN cord-005453-4057qib7 12928 25 blast blast NN cord-005453-4057qib7 12928 26 excess excess NN cord-005453-4057qib7 12928 27 and and CC cord-005453-4057qib7 12928 28 complex complex JJ cord-005453-4057qib7 12928 29 aberrant aberrant JJ cord-005453-4057qib7 12928 30 caryotype caryotype NN cord-005453-4057qib7 12928 31 . . . cord-005453-4057qib7 12929 1 The the DT cord-005453-4057qib7 12929 2 evolution evolution NN cord-005453-4057qib7 12929 3 of of IN cord-005453-4057qib7 12929 4 a a DT cord-005453-4057qib7 12929 5 trisomy trisomy NN cord-005453-4057qib7 12929 6 8 8 CD cord-005453-4057qib7 12929 7 clone clone NN cord-005453-4057qib7 12929 8 to to IN cord-005453-4057qib7 12929 9 tetrasomy tetrasomy NN cord-005453-4057qib7 12929 10 8 8 CD cord-005453-4057qib7 12929 11 clone clone NN cord-005453-4057qib7 12929 12 in in IN cord-005453-4057qib7 12929 13 relapse relapse NN cord-005453-4057qib7 12929 14 is be VBZ cord-005453-4057qib7 12929 15 linked link VBN cord-005453-4057qib7 12929 16 to to IN cord-005453-4057qib7 12929 17 extramedullar extramedullar JJ cord-005453-4057qib7 12929 18 manifestations manifestation NNS cord-005453-4057qib7 12929 19 . . . cord-005453-4057qib7 12930 1 Whether whether IN cord-005453-4057qib7 12930 2 the the DT cord-005453-4057qib7 12930 3 solid solid JJ cord-005453-4057qib7 12930 4 tumour tumour NN cord-005453-4057qib7 12930 5 represents represent VBZ cord-005453-4057qib7 12930 6 myeloid myeloid JJ cord-005453-4057qib7 12930 7 sarcoma sarcoma NN cord-005453-4057qib7 12930 8 with with IN cord-005453-4057qib7 12930 9 coexpression coexpression NN cord-005453-4057qib7 12930 10 of of IN cord-005453-4057qib7 12930 11 lymphoid lymphoid JJ cord-005453-4057qib7 12930 12 markers marker NNS cord-005453-4057qib7 12930 13 , , , cord-005453-4057qib7 12931 1 extramedullary extramedullary JJ cord-005453-4057qib7 12931 2 relapse relapse NN cord-005453-4057qib7 12931 3 of of IN cord-005453-4057qib7 12931 4 MDS MDS NNP cord-005453-4057qib7 12931 5 with with IN cord-005453-4057qib7 12931 6 lymphoid lymphoid JJ cord-005453-4057qib7 12931 7 differentiation differentiation NN cord-005453-4057qib7 12931 8 or or CC cord-005453-4057qib7 12931 9 , , , cord-005453-4057qib7 12931 10 less less RBR cord-005453-4057qib7 12931 11 likely likely JJ cord-005453-4057qib7 12931 12 , , , cord-005453-4057qib7 12931 13 a a DT cord-005453-4057qib7 12931 14 separate separate JJ cord-005453-4057qib7 12931 15 lymphobastic lymphobastic JJ cord-005453-4057qib7 12931 16 lymphoma lymphoma NN cord-005453-4057qib7 12931 17 , , , cord-005453-4057qib7 12931 18 is be VBZ cord-005453-4057qib7 12931 19 not not RB cord-005453-4057qib7 12931 20 yet yet RB cord-005453-4057qib7 12931 21 clear clear JJ cord-005453-4057qib7 12931 22 . . . cord-005453-4057qib7 12932 1 Disclosure disclosure NN cord-005453-4057qib7 12932 2 Background background NN cord-005453-4057qib7 12932 3 : : : cord-005453-4057qib7 12933 1 Adoptive adoptive JJ cord-005453-4057qib7 12933 2 T T NNP cord-005453-4057qib7 12933 3 cell cell NN cord-005453-4057qib7 12933 4 therapy therapy NN cord-005453-4057qib7 12933 5 with with IN cord-005453-4057qib7 12933 6 genetically genetically RB cord-005453-4057qib7 12933 7 engineered engineer VBN cord-005453-4057qib7 12933 8 T t NN cord-005453-4057qib7 12933 9 cells cell NNS cord-005453-4057qib7 12933 10 is be VBZ cord-005453-4057qib7 12933 11 a a DT cord-005453-4057qib7 12933 12 potent potent JJ cord-005453-4057qib7 12933 13 innovative innovative JJ cord-005453-4057qib7 12933 14 immunotherapeutic immunotherapeutic JJ cord-005453-4057qib7 12933 15 approach approach NN cord-005453-4057qib7 12933 16 for for IN cord-005453-4057qib7 12933 17 cancer cancer NN cord-005453-4057qib7 12933 18 treatment treatment NN cord-005453-4057qib7 12933 19 . . . cord-005453-4057qib7 12934 1 Unfortunately unfortunately RB cord-005453-4057qib7 12934 2 , , , cord-005453-4057qib7 12934 3 the the DT cord-005453-4057qib7 12934 4 use use NN cord-005453-4057qib7 12934 5 of of IN cord-005453-4057qib7 12934 6 T T NNP cord-005453-4057qib7 12934 7 cells cell NNS cord-005453-4057qib7 12934 8 redirected redirect VBN cord-005453-4057qib7 12934 9 against against IN cord-005453-4057qib7 12934 10 tumor tumor NN cord-005453-4057qib7 12934 11 antigens antigen NNS cord-005453-4057qib7 12934 12 , , , cord-005453-4057qib7 12934 13 is be VBZ cord-005453-4057qib7 12934 14 severely severely RB cord-005453-4057qib7 12934 15 limited limit VBN cord-005453-4057qib7 12934 16 by by IN cord-005453-4057qib7 12934 17 1 1 CD cord-005453-4057qib7 12934 18 ) ) -RRB- cord-005453-4057qib7 12934 19 the the DT cord-005453-4057qib7 12934 20 difficulty difficulty NN cord-005453-4057qib7 12934 21 in in IN cord-005453-4057qib7 12934 22 identifying identify VBG cord-005453-4057qib7 12934 23 appropriate appropriate JJ cord-005453-4057qib7 12934 24 cell cell NN cord-005453-4057qib7 12934 25 surface surface NN cord-005453-4057qib7 12934 26 antigens antigen NNS cord-005453-4057qib7 12934 27 , , , cord-005453-4057qib7 12934 28 that that WDT cord-005453-4057qib7 12934 29 could could MD cord-005453-4057qib7 12934 30 be be VB cord-005453-4057qib7 12934 31 targeted target VBN cord-005453-4057qib7 12934 32 by by IN cord-005453-4057qib7 12934 33 CAR car NN cord-005453-4057qib7 12934 34 T T NNP cord-005453-4057qib7 12934 35 cells cell NNS cord-005453-4057qib7 12934 36 and and CC cord-005453-4057qib7 12934 37 2 2 CD cord-005453-4057qib7 12934 38 ) ) -RRB- cord-005453-4057qib7 12935 1 the the DT cord-005453-4057qib7 12935 2 paucity paucity NN cord-005453-4057qib7 12935 3 of of IN cord-005453-4057qib7 12935 4 tumor tumor NN cord-005453-4057qib7 12935 5 - - HYPH cord-005453-4057qib7 12935 6 specific specific JJ cord-005453-4057qib7 12935 7 T T NNP cord-005453-4057qib7 12935 8 cell cell NN cord-005453-4057qib7 12935 9 receptors receptor NNS cord-005453-4057qib7 12935 10 ( ( -LRB- cord-005453-4057qib7 12935 11 TCRs TCRs NNP cord-005453-4057qib7 12935 12 ) ) -RRB- cord-005453-4057qib7 12935 13 against against IN cord-005453-4057qib7 12935 14 shared share VBN cord-005453-4057qib7 12935 15 , , , cord-005453-4057qib7 12935 16 oncogenic oncogenic JJ cord-005453-4057qib7 12935 17 antigens antigen NNS cord-005453-4057qib7 12935 18 . . . cord-005453-4057qib7 12936 1 Methods method NNS cord-005453-4057qib7 12936 2 : : : cord-005453-4057qib7 12936 3 Focusing focus VBG cord-005453-4057qib7 12936 4 on on IN cord-005453-4057qib7 12936 5 Wilms´Tumor Wilms´Tumor NNP cord-005453-4057qib7 12936 6 1 1 CD cord-005453-4057qib7 12936 7 ( ( -LRB- cord-005453-4057qib7 12936 8 WT1 WT1 NNP cord-005453-4057qib7 12936 9 ) ) -RRB- cord-005453-4057qib7 12936 10 , , , cord-005453-4057qib7 12936 11 a a DT cord-005453-4057qib7 12936 12 tumorassociated tumorassociated JJ cord-005453-4057qib7 12936 13 antigen antigen NN cord-005453-4057qib7 12936 14 overexpressed overexpresse VBN cord-005453-4057qib7 12936 15 by by IN cord-005453-4057qib7 12936 16 acute acute JJ cord-005453-4057qib7 12936 17 myeloid myeloid NN cord-005453-4057qib7 12936 18 leukemia leukemia NN cord-005453-4057qib7 12936 19 and and CC cord-005453-4057qib7 12936 20 several several JJ cord-005453-4057qib7 12936 21 solid solid JJ cord-005453-4057qib7 12936 22 tumors tumor NNS cord-005453-4057qib7 12936 23 , , , cord-005453-4057qib7 12936 24 we -PRON- PRP cord-005453-4057qib7 12936 25 designed design VBD cord-005453-4057qib7 12936 26 and and CC cord-005453-4057qib7 12936 27 implemented implement VBD cord-005453-4057qib7 12936 28 an an DT cord-005453-4057qib7 12936 29 innovative innovative JJ cord-005453-4057qib7 12936 30 protocol protocol NN cord-005453-4057qib7 12936 31 for for IN cord-005453-4057qib7 12936 32 the the DT cord-005453-4057qib7 12936 33 rapid rapid JJ cord-005453-4057qib7 12936 34 isolation isolation NN cord-005453-4057qib7 12936 35 of of IN cord-005453-4057qib7 12936 36 WT1-specific WT1-specific NNP cord-005453-4057qib7 12936 37 T T NNP cord-005453-4057qib7 12936 38 cells cell NNS cord-005453-4057qib7 12936 39 and and CC cord-005453-4057qib7 12936 40 for for IN cord-005453-4057qib7 12936 41 the the DT cord-005453-4057qib7 12936 42 generation generation NN cord-005453-4057qib7 12936 43 and and CC cord-005453-4057qib7 12936 44 characterization characterization NN cord-005453-4057qib7 12936 45 of of IN cord-005453-4057qib7 12936 46 a a DT cord-005453-4057qib7 12936 47 library library NN cord-005453-4057qib7 12936 48 of of IN cord-005453-4057qib7 12936 49 WT1-specific WT1-specific NNP cord-005453-4057qib7 12936 50 TCRs TCRs NNPS cord-005453-4057qib7 12936 51 displaying display VBG cord-005453-4057qib7 12936 52 different different JJ cord-005453-4057qib7 12936 53 human human JJ cord-005453-4057qib7 12936 54 leukocyte leukocyte NN cord-005453-4057qib7 12936 55 antigen antigen NN cord-005453-4057qib7 12936 56 ( ( -LRB- cord-005453-4057qib7 12936 57 HLA HLA NNP cord-005453-4057qib7 12936 58 ) ) -RRB- cord-005453-4057qib7 12936 59 restrictions restriction NNS cord-005453-4057qib7 12936 60 , , , cord-005453-4057qib7 12936 61 to to TO cord-005453-4057qib7 12936 62 be be VB cord-005453-4057qib7 12936 63 exploited exploit VBN cord-005453-4057qib7 12936 64 by by IN cord-005453-4057qib7 12936 65 TCR TCR NNP cord-005453-4057qib7 12936 66 gene gene NN cord-005453-4057qib7 12936 67 transfer transfer NN cord-005453-4057qib7 12936 68 and and CC cord-005453-4057qib7 12936 69 TCR TCR NNP cord-005453-4057qib7 12936 70 gene gene NN cord-005453-4057qib7 12936 71 editing editing NN cord-005453-4057qib7 12936 72 . . . cord-005453-4057qib7 12937 1 To to IN cord-005453-4057qib7 12937 2 this this DT cord-005453-4057qib7 12937 3 aim aim NN cord-005453-4057qib7 12937 4 , , , cord-005453-4057qib7 12937 5 we -PRON- PRP cord-005453-4057qib7 12937 6 repetitively repetitively RB cord-005453-4057qib7 12937 7 stimulated stimulate VBD cord-005453-4057qib7 12937 8 T t NN cord-005453-4057qib7 12937 9 cells cell NNS cord-005453-4057qib7 12937 10 with with IN cord-005453-4057qib7 12937 11 autologous autologous JJ cord-005453-4057qib7 12937 12 antigen antigen NN cord-005453-4057qib7 12937 13 - - HYPH cord-005453-4057qib7 12937 14 presenting present VBG cord-005453-4057qib7 12937 15 cells cell NNS cord-005453-4057qib7 12937 16 , , , cord-005453-4057qib7 12937 17 including include VBG cord-005453-4057qib7 12937 18 immortalized immortalize VBN cord-005453-4057qib7 12937 19 B b NN cord-005453-4057qib7 12937 20 cells cell NNS cord-005453-4057qib7 12937 21 , , , cord-005453-4057qib7 12937 22 pulsed pulse VBN cord-005453-4057qib7 12937 23 with with IN cord-005453-4057qib7 12937 24 overlapping overlap VBG cord-005453-4057qib7 12937 25 peptides peptide NNS cord-005453-4057qib7 12937 26 spanning span VBG cord-005453-4057qib7 12937 27 the the DT cord-005453-4057qib7 12937 28 entire entire JJ cord-005453-4057qib7 12937 29 WT1 WT1 NNP cord-005453-4057qib7 12937 30 protein protein NN cord-005453-4057qib7 12937 31 . . . cord-005453-4057qib7 12938 1 T T NNP cord-005453-4057qib7 12938 2 cell cell NN cord-005453-4057qib7 12938 3 recognition recognition NN cord-005453-4057qib7 12938 4 was be VBD cord-005453-4057qib7 12938 5 assessed assess VBN cord-005453-4057qib7 12938 6 by by IN cord-005453-4057qib7 12938 7 flow flow NN cord-005453-4057qib7 12938 8 cytometry cytometry NN cord-005453-4057qib7 12938 9 in in IN cord-005453-4057qib7 12938 10 terms term NNS cord-005453-4057qib7 12938 11 of of IN cord-005453-4057qib7 12938 12 CD107a CD107a NNP cord-005453-4057qib7 12938 13 expression expression NN cord-005453-4057qib7 12938 14 and and CC cord-005453-4057qib7 12938 15 IFNγ IFNγ NNS cord-005453-4057qib7 12938 16 production production NN cord-005453-4057qib7 12938 17 . . . cord-005453-4057qib7 12939 1 Recognized recognize VBN cord-005453-4057qib7 12939 2 peptides peptide NNS cord-005453-4057qib7 12939 3 were be VBD cord-005453-4057qib7 12939 4 mapped map VBN cord-005453-4057qib7 12939 5 by by IN cord-005453-4057qib7 12939 6 a a DT cord-005453-4057qib7 12939 7 deconvoluting deconvolute VBG cord-005453-4057qib7 12939 8 grid grid NN cord-005453-4057qib7 12939 9 and and CC cord-005453-4057qib7 12939 10 T T NNP cord-005453-4057qib7 12939 11 cell cell NN cord-005453-4057qib7 12939 12 clonotypes clonotype NNS cord-005453-4057qib7 12939 13 were be VBD cord-005453-4057qib7 12939 14 longitudinally longitudinally RB cord-005453-4057qib7 12939 15 tracked track VBN cord-005453-4057qib7 12939 16 by by IN cord-005453-4057qib7 12939 17 TCRαβ tcrαβ CD cord-005453-4057qib7 12939 18 sequencing sequencing NN cord-005453-4057qib7 12939 19 . . . cord-005453-4057qib7 12940 1 Results result NNS cord-005453-4057qib7 12940 2 : : : cord-005453-4057qib7 12941 1 We -PRON- PRP cord-005453-4057qib7 12941 2 successfully successfully RB cord-005453-4057qib7 12941 3 expanded expand VBD cord-005453-4057qib7 12941 4 tumor tumor NN cord-005453-4057qib7 12941 5 - - HYPH cord-005453-4057qib7 12941 6 specific specific JJ cord-005453-4057qib7 12941 7 T t NN cord-005453-4057qib7 12941 8 cells cell NNS cord-005453-4057qib7 12941 9 from from IN cord-005453-4057qib7 12941 10 14 14 CD cord-005453-4057qib7 12941 11 consecutive consecutive JJ cord-005453-4057qib7 12941 12 healthy healthy JJ cord-005453-4057qib7 12941 13 donors donor NNS cord-005453-4057qib7 12941 14 , , , cord-005453-4057qib7 12941 15 in in IN cord-005453-4057qib7 12941 16 an an DT cord-005453-4057qib7 12941 17 average average NN cord-005453-4057qib7 12941 18 of of IN cord-005453-4057qib7 12941 19 4 4 CD cord-005453-4057qib7 12941 20 rounds round NNS cord-005453-4057qib7 12941 21 of of IN cord-005453-4057qib7 12941 22 in in FW cord-005453-4057qib7 12941 23 vitro vitro FW cord-005453-4057qib7 12941 24 stimulations stimulation NNS cord-005453-4057qib7 12941 25 . . . cord-005453-4057qib7 12942 1 The the DT cord-005453-4057qib7 12942 2 ability ability NN cord-005453-4057qib7 12942 3 of of IN cord-005453-4057qib7 12942 4 WT1specific WT1specific NNP cord-005453-4057qib7 12942 5 T t NN cord-005453-4057qib7 12942 6 cells cell NNS cord-005453-4057qib7 12942 7 to to TO cord-005453-4057qib7 12942 8 recognize recognize VB cord-005453-4057qib7 12942 9 naturally naturally RB cord-005453-4057qib7 12942 10 processed process VBN cord-005453-4057qib7 12942 11 epitopes epitope NNS cord-005453-4057qib7 12942 12 and and CC cord-005453-4057qib7 12942 13 their -PRON- PRP$ cord-005453-4057qib7 12942 14 on on IN cord-005453-4057qib7 12942 15 - - HYPH cord-005453-4057qib7 12942 16 target target NN cord-005453-4057qib7 12942 17 specificity specificity NN cord-005453-4057qib7 12942 18 was be VBD cord-005453-4057qib7 12942 19 demonstrated demonstrate VBN cord-005453-4057qib7 12942 20 upon upon IN cord-005453-4057qib7 12942 21 coculture coculture NN cord-005453-4057qib7 12942 22 with with IN cord-005453-4057qib7 12942 23 antigen antigen NN cord-005453-4057qib7 12942 24 - - HYPH cord-005453-4057qib7 12942 25 expressing express VBG cord-005453-4057qib7 12942 26 targets target NNS cord-005453-4057qib7 12942 27 including include VBG cord-005453-4057qib7 12942 28 primary primary JJ cord-005453-4057qib7 12942 29 leukemic leukemic JJ cord-005453-4057qib7 12942 30 blasts blast NNS cord-005453-4057qib7 12942 31 . . . cord-005453-4057qib7 12943 1 Tracking tracking NN cord-005453-4057qib7 12943 2 of of IN cord-005453-4057qib7 12943 3 the the DT cord-005453-4057qib7 12943 4 TCRαβ TCRαβ NNP cord-005453-4057qib7 12943 5 repertoire repertoire NN cord-005453-4057qib7 12943 6 during during IN cord-005453-4057qib7 12943 7 culture culture NN cord-005453-4057qib7 12943 8 led lead VBD cord-005453-4057qib7 12943 9 to to IN cord-005453-4057qib7 12943 10 the the DT cord-005453-4057qib7 12943 11 identification identification NN cord-005453-4057qib7 12943 12 of of IN cord-005453-4057qib7 12943 13 20 20 CD cord-005453-4057qib7 12943 14 clonotypes clonotype NNS cord-005453-4057qib7 12943 15 that that WDT cord-005453-4057qib7 12943 16 recognize recognize VBP cord-005453-4057qib7 12943 17 several several JJ cord-005453-4057qib7 12943 18 tumor tumor NN cord-005453-4057qib7 12943 19 - - HYPH cord-005453-4057qib7 12943 20 associated associate VBN cord-005453-4057qib7 12943 21 peptides peptide NNS cord-005453-4057qib7 12943 22 and and CC cord-005453-4057qib7 12943 23 are be VBP cord-005453-4057qib7 12943 24 restricted restrict VBN cord-005453-4057qib7 12943 25 by by IN cord-005453-4057qib7 12943 26 more more JJR cord-005453-4057qib7 12943 27 than than IN cord-005453-4057qib7 12943 28 5 5 CD cord-005453-4057qib7 12943 29 HLA HLA NNP cord-005453-4057qib7 12943 30 alleles allele NNS cord-005453-4057qib7 12943 31 , , , cord-005453-4057qib7 12943 32 including include VBG cord-005453-4057qib7 12943 33 HLA HLA NNP cord-005453-4057qib7 12943 34 - - HYPH cord-005453-4057qib7 12943 35 A*02:01 A*02:01 NNP cord-005453-4057qib7 12943 36 . . . cord-005453-4057qib7 12944 1 TCRs tcr NNS cord-005453-4057qib7 12944 2 were be VBD cord-005453-4057qib7 12944 3 then then RB cord-005453-4057qib7 12944 4 expressed express VBN cord-005453-4057qib7 12944 5 via via IN cord-005453-4057qib7 12944 6 genome genome NN cord-005453-4057qib7 12944 7 editing editing NN cord-005453-4057qib7 12944 8 . . . cord-005453-4057qib7 12945 1 Briefly briefly RB cord-005453-4057qib7 12945 2 , , , cord-005453-4057qib7 12945 3 simultaneous simultaneous JJ cord-005453-4057qib7 12945 4 editing editing NN cord-005453-4057qib7 12945 5 of of IN cord-005453-4057qib7 12945 6 endogenous endogenous JJ cord-005453-4057qib7 12945 7 TCR TCR NNP cord-005453-4057qib7 12945 8 α α NNP cord-005453-4057qib7 12945 9 and and CC cord-005453-4057qib7 12945 10 β β NN cord-005453-4057qib7 12945 11 chain chain NN cord-005453-4057qib7 12945 12 genes gene NNS cord-005453-4057qib7 12945 13 was be VBD cord-005453-4057qib7 12945 14 achieved achieve VBN cord-005453-4057qib7 12945 15 using use VBG cord-005453-4057qib7 12945 16 CRISPR CRISPR NNP cord-005453-4057qib7 12945 17 / / SYM cord-005453-4057qib7 12945 18 Cas9 Cas9 NNP cord-005453-4057qib7 12945 19 technology technology NN cord-005453-4057qib7 12945 20 ( ( -LRB- cord-005453-4057qib7 12945 21 efficiency efficiency NN cord-005453-4057qib7 12945 22 > > XX cord-005453-4057qib7 12945 23 90 90 CD cord-005453-4057qib7 12945 24 % % NN cord-005453-4057qib7 12945 25 ) ) -RRB- cord-005453-4057qib7 12945 26 , , , cord-005453-4057qib7 12945 27 followed follow VBN cord-005453-4057qib7 12945 28 by by IN cord-005453-4057qib7 12945 29 transduction transduction NN cord-005453-4057qib7 12945 30 of of IN cord-005453-4057qib7 12945 31 T T NNP cord-005453-4057qib7 12945 32 cells cell NNS cord-005453-4057qib7 12945 33 with with IN cord-005453-4057qib7 12945 34 lentiviral lentiviral JJ cord-005453-4057qib7 12945 35 vectors vector NNS cord-005453-4057qib7 12945 36 encoding encode VBG cord-005453-4057qib7 12945 37 WT1-specific WT1-specific NNP cord-005453-4057qib7 12945 38 TCRs tcr NNS cord-005453-4057qib7 12945 39 ( ( -LRB- cord-005453-4057qib7 12945 40 efficiency efficiency NN cord-005453-4057qib7 12945 41 > > XX cord-005453-4057qib7 12945 42 95 95 CD cord-005453-4057qib7 12945 43 % % NN cord-005453-4057qib7 12945 44 of of IN cord-005453-4057qib7 12945 45 CD8 CD8 NNP cord-005453-4057qib7 12945 46 + + CC cord-005453-4057qib7 12945 47 T T NNP cord-005453-4057qib7 12945 48 cells cell NNS cord-005453-4057qib7 12945 49 ) ) -RRB- cord-005453-4057qib7 12945 50 . . . cord-005453-4057qib7 12946 1 Phenotypic phenotypic JJ cord-005453-4057qib7 12946 2 characterization characterization NN cord-005453-4057qib7 12946 3 of of IN cord-005453-4057qib7 12946 4 edited edit VBN cord-005453-4057qib7 12946 5 T t NN cord-005453-4057qib7 12946 6 lymphocytes lymphocyte NNS cord-005453-4057qib7 12946 7 showed show VBD cord-005453-4057qib7 12946 8 a a DT cord-005453-4057qib7 12946 9 major major JJ cord-005453-4057qib7 12946 10 enrichment enrichment NN cord-005453-4057qib7 12946 11 of of IN cord-005453-4057qib7 12946 12 cells cell NNS cord-005453-4057qib7 12946 13 harboring harbor VBG cord-005453-4057qib7 12946 14 T T NNP cord-005453-4057qib7 12946 15 stem stem NN cord-005453-4057qib7 12946 16 cell cell NN cord-005453-4057qib7 12946 17 memory memory NN cord-005453-4057qib7 12946 18 properties property NNS cord-005453-4057qib7 12946 19 . . . cord-005453-4057qib7 12947 1 Functional functional JJ cord-005453-4057qib7 12947 2 validation validation NN cord-005453-4057qib7 12947 3 of of IN cord-005453-4057qib7 12947 4 the the DT cord-005453-4057qib7 12947 5 edited edit VBN cord-005453-4057qib7 12947 6 T t NN cord-005453-4057qib7 12947 7 cells cell NNS cord-005453-4057qib7 12947 8 is be VBZ cord-005453-4057qib7 12947 9 currently currently RB cord-005453-4057qib7 12947 10 ongoing ongoing JJ cord-005453-4057qib7 12947 11 . . . cord-005453-4057qib7 12948 1 Preliminary preliminary JJ cord-005453-4057qib7 12948 2 results result NNS cord-005453-4057qib7 12948 3 of of IN cord-005453-4057qib7 12948 4 a a DT cord-005453-4057qib7 12948 5 6 6 CD cord-005453-4057qib7 12948 6 hours hour NNS cord-005453-4057qib7 12948 7 coculture coculture NN cord-005453-4057qib7 12948 8 experiment experiment NN cord-005453-4057qib7 12948 9 show show VBP cord-005453-4057qib7 12948 10 that that IN cord-005453-4057qib7 12948 11 TCR TCR NNP cord-005453-4057qib7 12948 12 edited edit VBD cord-005453-4057qib7 12948 13 T t NN cord-005453-4057qib7 12948 14 cells cell NNS cord-005453-4057qib7 12948 15 kill kill VBP cord-005453-4057qib7 12948 16 fresh fresh JJ cord-005453-4057qib7 12948 17 WT1 WT1 NNP cord-005453-4057qib7 12948 18 + + CC cord-005453-4057qib7 12948 19 leukemic leukemic JJ cord-005453-4057qib7 12948 20 blasts blast NNS cord-005453-4057qib7 12948 21 , , , cord-005453-4057qib7 12948 22 harvested harvest VBN cord-005453-4057qib7 12948 23 from from IN cord-005453-4057qib7 12948 24 HLA HLA NNP cord-005453-4057qib7 12948 25 - - HYPH cord-005453-4057qib7 12948 26 matched match VBN cord-005453-4057qib7 12948 27 patients patient NNS cord-005453-4057qib7 12948 28 , , , cord-005453-4057qib7 12948 29 with with IN cord-005453-4057qib7 12948 30 an an DT cord-005453-4057qib7 12948 31 efficiency efficiency NN cord-005453-4057qib7 12948 32 up up IN cord-005453-4057qib7 12948 33 to to TO cord-005453-4057qib7 12948 34 70 70 CD cord-005453-4057qib7 12948 35 % % NN cord-005453-4057qib7 12948 36 at at IN cord-005453-4057qib7 12948 37 an an DT cord-005453-4057qib7 12948 38 effector effector NN cord-005453-4057qib7 12948 39 to to TO cord-005453-4057qib7 12948 40 target target VB cord-005453-4057qib7 12948 41 ratio ratio NN cord-005453-4057qib7 12948 42 of of IN cord-005453-4057qib7 12948 43 5 5 CD cord-005453-4057qib7 12948 44 to to IN cord-005453-4057qib7 12948 45 1 1 CD cord-005453-4057qib7 12948 46 , , , cord-005453-4057qib7 12948 47 while while IN cord-005453-4057qib7 12948 48 no no DT cord-005453-4057qib7 12948 49 killing killing NN cord-005453-4057qib7 12948 50 of of IN cord-005453-4057qib7 12948 51 controls control NNS cord-005453-4057qib7 12948 52 is be VBZ cord-005453-4057qib7 12948 53 observed observe VBN cord-005453-4057qib7 12948 54 . . . cord-005453-4057qib7 12949 1 Conclusions conclusion NNS cord-005453-4057qib7 12949 2 : : : cord-005453-4057qib7 12950 1 We -PRON- PRP cord-005453-4057qib7 12950 2 set set VBD cord-005453-4057qib7 12950 3 up up RP cord-005453-4057qib7 12950 4 a a DT cord-005453-4057qib7 12950 5 protocol protocol NN cord-005453-4057qib7 12950 6 enabling enable VBG cord-005453-4057qib7 12950 7 consistent consistent JJ cord-005453-4057qib7 12950 8 and and CC cord-005453-4057qib7 12950 9 efficient efficient JJ cord-005453-4057qib7 12950 10 hunting hunting NN cord-005453-4057qib7 12950 11 for for IN cord-005453-4057qib7 12950 12 tumor tumor NN cord-005453-4057qib7 12950 13 - - HYPH cord-005453-4057qib7 12950 14 specific specific JJ cord-005453-4057qib7 12950 15 TCRs tcr NNS cord-005453-4057qib7 12950 16 with with IN cord-005453-4057qib7 12950 17 no no DT cord-005453-4057qib7 12950 18 need need NN cord-005453-4057qib7 12950 19 for for IN cord-005453-4057qib7 12950 20 labor labor NN cord-005453-4057qib7 12950 21 intensive intensive JJ cord-005453-4057qib7 12950 22 T t NN cord-005453-4057qib7 12950 23 cell cell NN cord-005453-4057qib7 12950 24 cloning cloning NN cord-005453-4057qib7 12950 25 . . . cord-005453-4057qib7 12951 1 TCR TCR NNP cord-005453-4057qib7 12951 2 genes gene NNS cord-005453-4057qib7 12951 3 can can MD cord-005453-4057qib7 12951 4 be be VB cord-005453-4057qib7 12951 5 easily easily RB cord-005453-4057qib7 12951 6 and and CC cord-005453-4057qib7 12951 7 rapidly rapidly RB cord-005453-4057qib7 12951 8 used use VBN cord-005453-4057qib7 12951 9 to to TO cord-005453-4057qib7 12951 10 redirect redirect VB cord-005453-4057qib7 12951 11 T T NNP cord-005453-4057qib7 12951 12 cell cell NN cord-005453-4057qib7 12951 13 specificity specificity NN cord-005453-4057qib7 12951 14 against against IN cord-005453-4057qib7 12951 15 cancer cancer NN cord-005453-4057qib7 12951 16 cells cell NNS cord-005453-4057qib7 12951 17 by by IN cord-005453-4057qib7 12951 18 TCR TCR NNP cord-005453-4057qib7 12951 19 gene gene NN cord-005453-4057qib7 12951 20 editing editing NN cord-005453-4057qib7 12951 21 . . . cord-005453-4057qib7 12952 1 Disclosure disclosure NN cord-005453-4057qib7 12952 2 : : : cord-005453-4057qib7 12952 3 Chiara Chiara NNP cord-005453-4057qib7 12953 1 Bonini Bonini NNP cord-005453-4057qib7 12953 2 : : : cord-005453-4057qib7 12953 3 Research research NN cord-005453-4057qib7 12953 4 funding funding NN cord-005453-4057qib7 12953 5 from from IN cord-005453-4057qib7 12953 6 Intellia Intellia NNP cord-005453-4057qib7 12953 7 Therapeutics Therapeutics NNP cord-005453-4057qib7 12953 8 P583 P583 NNP cord-005453-4057qib7 12953 9 CAR car NN cord-005453-4057qib7 12953 10 T t NN cord-005453-4057qib7 12953 11 cell cell NN cord-005453-4057qib7 12953 12 therapy therapy NN cord-005453-4057qib7 12953 13 targeting target VBG cord-005453-4057qib7 12953 14 relapsed relapse VBN cord-005453-4057qib7 12953 15 or or CC cord-005453-4057qib7 12953 16 refractory refractory JJ cord-005453-4057qib7 12954 1 CD19 CD19 NNP cord-005453-4057qib7 12954 2 + + CC cord-005453-4057qib7 12954 3 lymphoid lymphoid JJ cord-005453-4057qib7 12954 4 disease disease NN cord-005453-4057qib7 12954 5 with with IN cord-005453-4057qib7 12954 6 third third JJ cord-005453-4057qib7 12954 7 - - HYPH cord-005453-4057qib7 12954 8 generation generation NN cord-005453-4057qib7 12954 9 vector vector NN cord-005453-4057qib7 12954 10 RV RV NNP cord-005453-4057qib7 12955 1 -SFG.CD19.CD28.4 -SFG.CD19.CD28.4 NNS cord-005453-4057qib7 12955 2 - - : cord-005453-4057qib7 12955 3 1BBZETA 1bbzeta CD cord-005453-4057qib7 12955 4 Maria Maria NNP cord-005453-4057qib7 12955 5 - - HYPH cord-005453-4057qib7 12955 6 Luisa Luisa NNP cord-005453-4057qib7 12955 7 Schubert Schubert NNP cord-005453-4057qib7 12955 8 1 1 CD cord-005453-4057qib7 12955 9 , , , cord-005453-4057qib7 12955 10 Anita Anita NNP cord-005453-4057qib7 12955 11 Schmitt Schmitt NNP cord-005453-4057qib7 12955 12 1 1 CD cord-005453-4057qib7 12955 13 , , , cord-005453-4057qib7 12955 14 Leopold Leopold NNP cord-005453-4057qib7 12955 15 Sellner Sellner NNP cord-005453-4057qib7 12955 16 1,2 1,2 CD cord-005453-4057qib7 12955 17 , , , cord-005453-4057qib7 12955 18 Brigitte Brigitte NNP cord-005453-4057qib7 12955 19 Neuber Neuber NNP cord-005453-4057qib7 12955 20 1 1 CD cord-005453-4057qib7 12955 21 , , , cord-005453-4057qib7 12955 22 Angela Angela NNP cord-005453-4057qib7 12955 23 Hückelhoven Hückelhoven NNP cord-005453-4057qib7 12955 24 - - HYPH cord-005453-4057qib7 12955 25 Krauss Krauss NNP cord-005453-4057qib7 12955 26 1 1 CD cord-005453-4057qib7 12955 27 , , , cord-005453-4057qib7 12955 28 Kunz Kunz NNP cord-005453-4057qib7 12955 29 Alexander Alexander NNP cord-005453-4057qib7 12955 30 1 1 CD cord-005453-4057qib7 12955 31 , , , cord-005453-4057qib7 12955 32 Lei Lei NNP cord-005453-4057qib7 12955 33 Wang Wang NNP cord-005453-4057qib7 12955 34 1 1 CD cord-005453-4057qib7 12955 35 , , , cord-005453-4057qib7 12955 36 Gern Gern NNP cord-005453-4057qib7 12955 37 Ulrike Ulrike NNP cord-005453-4057qib7 12955 38 1 1 CD cord-005453-4057qib7 12955 39 , , , cord-005453-4057qib7 12955 40 Birgit Birgit NNP cord-005453-4057qib7 12955 41 Michels Michels NNP cord-005453-4057qib7 12955 42 1 1 CD cord-005453-4057qib7 12955 43 , , , cord-005453-4057qib7 12955 44 Susanne Susanne NNP cord-005453-4057qib7 12955 45 Hofmann Hofmann NNP cord-005453-4057qib7 12955 46 1 1 CD cord-005453-4057qib7 12955 47 , , , cord-005453-4057qib7 12955 48 Carsten Carsten NNP cord-005453-4057qib7 12955 49 Mueller Mueller NNP cord-005453-4057qib7 12955 50 - - HYPH cord-005453-4057qib7 12955 51 Tidow Tidow NNP cord-005453-4057qib7 12955 52 1,2 1,2 CD cord-005453-4057qib7 12955 53 , , , cord-005453-4057qib7 12955 54 Dreger Dreger NNP cord-005453-4057qib7 12955 55 Peter Peter NNP cord-005453-4057qib7 12955 56 1,2 1,2 CD cord-005453-4057qib7 12955 57 , , , cord-005453-4057qib7 12955 58 Michael Michael NNP cord-005453-4057qib7 12955 59 Schmitt Schmitt NNP cord-005453-4057qib7 12955 60 1 1 CD cord-005453-4057qib7 12955 61 , , , cord-005453-4057qib7 12956 1 2 2 LS cord-005453-4057qib7 12956 2 Background background NN cord-005453-4057qib7 12956 3 : : : cord-005453-4057qib7 12956 4 T t NN cord-005453-4057qib7 12956 5 cells cell NNS cord-005453-4057qib7 12956 6 genetically genetically RB cord-005453-4057qib7 12956 7 engineered engineer VBN cord-005453-4057qib7 12956 8 to to TO cord-005453-4057qib7 12956 9 express express VB cord-005453-4057qib7 12956 10 chimeric chimeric JJ cord-005453-4057qib7 12956 11 antigen antigen NN cord-005453-4057qib7 12956 12 receptors receptor NNS cord-005453-4057qib7 12956 13 ( ( -LRB- cord-005453-4057qib7 12956 14 CARTs cart NNS cord-005453-4057qib7 12956 15 ) ) -RRB- cord-005453-4057qib7 12956 16 directed direct VBD cord-005453-4057qib7 12956 17 against against IN cord-005453-4057qib7 12956 18 CD19 CD19 NNP cord-005453-4057qib7 12956 19 have have VBP cord-005453-4057qib7 12956 20 demonstrated demonstrate VBN cord-005453-4057qib7 12956 21 significant significant JJ cord-005453-4057qib7 12956 22 efficacy efficacy NN cord-005453-4057qib7 12956 23 in in IN cord-005453-4057qib7 12956 24 patients patient NNS cord-005453-4057qib7 12956 25 with with IN cord-005453-4057qib7 12956 26 Iymphoid Iymphoid NNP cord-005453-4057qib7 12956 27 malignancies malignancy NNS cord-005453-4057qib7 12956 28 including include VBG cord-005453-4057qib7 12956 29 relapsed relapse VBN cord-005453-4057qib7 12956 30 or or CC cord-005453-4057qib7 12956 31 refractory refractory JJ cord-005453-4057qib7 12956 32 ( ( -LRB- cord-005453-4057qib7 12956 33 r r NN cord-005453-4057qib7 12956 34 / / SYM cord-005453-4057qib7 12956 35 r r NN cord-005453-4057qib7 12956 36 ) ) -RRB- cord-005453-4057qib7 12956 37 B b NN cord-005453-4057qib7 12956 38 - - HYPH cord-005453-4057qib7 12956 39 lineage lineage NN cord-005453-4057qib7 12956 40 acute acute JJ cord-005453-4057qib7 12956 41 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 12956 42 leukemia leukemia NN cord-005453-4057qib7 12956 43 ( ( -LRB- cord-005453-4057qib7 12956 44 ALL all DT cord-005453-4057qib7 12956 45 ) ) -RRB- cord-005453-4057qib7 12956 46 or or CC cord-005453-4057qib7 12956 47 r r NN cord-005453-4057qib7 12956 48 / / SYM cord-005453-4057qib7 12956 49 r r NN cord-005453-4057qib7 12956 50 B b NN cord-005453-4057qib7 12956 51 - - HYPH cord-005453-4057qib7 12956 52 cell cell NN cord-005453-4057qib7 12956 53 non non JJ cord-005453-4057qib7 12956 54 - - JJ cord-005453-4057qib7 12956 55 Hodgkin Hodgkin NNP cord-005453-4057qib7 12956 56 's 's POS cord-005453-4057qib7 12956 57 lymphoma lymphoma NN cord-005453-4057qib7 12956 58 ( ( -LRB- cord-005453-4057qib7 12956 59 NHL NHL NNP cord-005453-4057qib7 12956 60 ) ) -RRB- cord-005453-4057qib7 12956 61 . . . cord-005453-4057qib7 12957 1 Access access NN cord-005453-4057qib7 12957 2 to to IN cord-005453-4057qib7 12957 3 CART cart NN cord-005453-4057qib7 12957 4 treatment treatment NN cord-005453-4057qib7 12957 5 for for IN cord-005453-4057qib7 12957 6 patients patient NNS cord-005453-4057qib7 12957 7 in in IN cord-005453-4057qib7 12957 8 Europe Europe NNP cord-005453-4057qib7 12957 9 has have VBZ cord-005453-4057qib7 12957 10 been be VBN cord-005453-4057qib7 12957 11 limited limit VBN cord-005453-4057qib7 12957 12 so so RB cord-005453-4057qib7 12957 13 far far RB cord-005453-4057qib7 12957 14 given give VBN cord-005453-4057qib7 12957 15 that that IN cord-005453-4057qib7 12957 16 the the DT cord-005453-4057qib7 12957 17 vast vast JJ cord-005453-4057qib7 12957 18 majority majority NN cord-005453-4057qib7 12957 19 of of IN cord-005453-4057qib7 12957 20 CART cart NN cord-005453-4057qib7 12957 21 trials trial NNS cord-005453-4057qib7 12957 22 have have VBP cord-005453-4057qib7 12957 23 been be VBN cord-005453-4057qib7 12957 24 performed perform VBN cord-005453-4057qib7 12957 25 in in IN cord-005453-4057qib7 12957 26 the the DT cord-005453-4057qib7 12957 27 United United NNP cord-005453-4057qib7 12957 28 States States NNP cord-005453-4057qib7 12957 29 and and CC cord-005453-4057qib7 12957 30 the the DT cord-005453-4057qib7 12957 31 P. P. NNP cord-005453-4057qib7 12957 32 R. R. NNP cord-005453-4057qib7 12957 33 of of IN cord-005453-4057qib7 12957 34 China China NNP cord-005453-4057qib7 12957 35 . . . cord-005453-4057qib7 12958 1 Here here RB cord-005453-4057qib7 12958 2 we -PRON- PRP cord-005453-4057qib7 12958 3 present present VBP cord-005453-4057qib7 12958 4 the the DT cord-005453-4057qib7 12958 5 preliminary preliminary JJ cord-005453-4057qib7 12958 6 results result NNS cord-005453-4057qib7 12958 7 of of IN cord-005453-4057qib7 12958 8 the the DT cord-005453-4057qib7 12958 9 first first JJ cord-005453-4057qib7 12958 10 investigator investigator NN cord-005453-4057qib7 12958 11 - - HYPH cord-005453-4057qib7 12958 12 initiated initiate VBN cord-005453-4057qib7 12958 13 trial trial NN cord-005453-4057qib7 12958 14 ( ( -LRB- cord-005453-4057qib7 12958 15 IIT IIT NNP cord-005453-4057qib7 12958 16 ) ) -RRB- cord-005453-4057qib7 12958 17 CART cart NN cord-005453-4057qib7 12958 18 trial trial NN cord-005453-4057qib7 12958 19 in in IN cord-005453-4057qib7 12958 20 Germany Germany NNP cord-005453-4057qib7 12958 21 . . . cord-005453-4057qib7 12959 1 HD HD NNP cord-005453-4057qib7 12959 2 - - HYPH cord-005453-4057qib7 12959 3 CAR-1 CAR-1 NNP cord-005453-4057qib7 12960 1 ( ( -LRB- cord-005453-4057qib7 12960 2 EudraCT EudraCT NNP cord-005453-4057qib7 12960 3 No no UH cord-005453-4057qib7 12960 4 . . . cord-005453-4057qib7 12961 1 2016 2016 CD cord-005453-4057qib7 12961 2 - - SYM cord-005453-4057qib7 12961 3 00 00 CD cord-005453-4057qib7 12961 4 4808 4808 CD cord-005453-4057qib7 12961 5 - - SYM cord-005453-4057qib7 12961 6 60 60 CD cord-005453-4057qib7 12961 7 ; ; : cord-005453-4057qib7 12961 8 NCT03676504 NCT03676504 NNP cord-005453-4057qib7 12961 9 ) ) -RRB- cord-005453-4057qib7 12961 10 is be VBZ cord-005453-4057qib7 12961 11 a a DT cord-005453-4057qib7 12961 12 phase phase NN cord-005453-4057qib7 12961 13 I -PRON- PRP cord-005453-4057qib7 12961 14 / / SYM cord-005453-4057qib7 12961 15 II II NNP cord-005453-4057qib7 12961 16 trial trial NN cord-005453-4057qib7 12961 17 with with IN cord-005453-4057qib7 12961 18 in in IN cord-005453-4057qib7 12961 19 - - HYPH cord-005453-4057qib7 12961 20 house house NN cord-005453-4057qib7 12961 21 CART cart NN cord-005453-4057qib7 12961 22 manufacturing manufacturing NN cord-005453-4057qib7 12961 23 which which WDT cord-005453-4057qib7 12961 24 was be VBD cord-005453-4057qib7 12961 25 initiated initiate VBN cord-005453-4057qib7 12961 26 in in IN cord-005453-4057qib7 12961 27 September September NNP cord-005453-4057qib7 12961 28 2018 2018 CD cord-005453-4057qib7 12961 29 at at IN cord-005453-4057qib7 12961 30 the the DT cord-005453-4057qib7 12961 31 University University NNP cord-005453-4057qib7 12961 32 Hospital Hospital NNP cord-005453-4057qib7 12961 33 Heidelberg Heidelberg NNP cord-005453-4057qib7 12961 34 . . . cord-005453-4057qib7 12962 1 Methods method NNS cord-005453-4057qib7 12962 2 : : : cord-005453-4057qib7 12962 3 Adult adult NN cord-005453-4057qib7 12962 4 as as RB cord-005453-4057qib7 12962 5 well well RB cord-005453-4057qib7 12962 6 as as IN cord-005453-4057qib7 12963 1 pediatric pediatric JJ cord-005453-4057qib7 12963 2 patients patient NNS cord-005453-4057qib7 12963 3 with with IN cord-005453-4057qib7 12963 4 r r NN cord-005453-4057qib7 12963 5 / / SYM cord-005453-4057qib7 12963 6 r r NN cord-005453-4057qib7 12963 7 ALL all DT cord-005453-4057qib7 12963 8 and and CC cord-005453-4057qib7 12963 9 patients patient NNS cord-005453-4057qib7 12963 10 with with IN cord-005453-4057qib7 12963 11 chronic chronic JJ cord-005453-4057qib7 12963 12 lymphocytic lymphocytic JJ cord-005453-4057qib7 12963 13 leukemia leukemia NN cord-005453-4057qib7 12963 14 ( ( -LRB- cord-005453-4057qib7 12963 15 CLL CLL NNP cord-005453-4057qib7 12963 16 ) ) -RRB- cord-005453-4057qib7 12963 17 or or CC cord-005453-4057qib7 12963 18 NHL NHL NNP cord-005453-4057qib7 12963 19 including include VBG cord-005453-4057qib7 12963 20 diffuse diffuse VBP cord-005453-4057qib7 12963 21 large large JJ cord-005453-4057qib7 12963 22 B b NN cord-005453-4057qib7 12963 23 - - HYPH cord-005453-4057qib7 12963 24 cell cell NN cord-005453-4057qib7 12963 25 lymphoma lymphoma NN cord-005453-4057qib7 12963 26 ( ( -LRB- cord-005453-4057qib7 12963 27 DLBCL DLBCL NNP cord-005453-4057qib7 12963 28 ) ) -RRB- cord-005453-4057qib7 12963 29 , , , cord-005453-4057qib7 12963 30 follicular follicular JJ cord-005453-4057qib7 12963 31 lymphoma lymphoma NN cord-005453-4057qib7 12963 32 ( ( -LRB- cord-005453-4057qib7 12963 33 FL FL NNP cord-005453-4057qib7 12963 34 ) ) -RRB- cord-005453-4057qib7 12963 35 or or CC cord-005453-4057qib7 12963 36 mantle mantle NN cord-005453-4057qib7 12963 37 cell cell NN cord-005453-4057qib7 12963 38 lymphoma lymphoma NN cord-005453-4057qib7 12963 39 ( ( -LRB- cord-005453-4057qib7 12963 40 MCL MCL NNP cord-005453-4057qib7 12963 41 ) ) -RRB- cord-005453-4057qib7 12963 42 are be VBP cord-005453-4057qib7 12963 43 treated treat VBN cord-005453-4057qib7 12963 44 with with IN cord-005453-4057qib7 12963 45 autologous autologous JJ cord-005453-4057qib7 12963 46 T t NN cord-005453-4057qib7 12963 47 lymphocytes lymphocyte NNS cord-005453-4057qib7 12963 48 transduced transduce VBN cord-005453-4057qib7 12963 49 with with IN cord-005453-4057qib7 12963 50 a a DT cord-005453-4057qib7 12963 51 third third JJ cord-005453-4057qib7 12963 52 - - HYPH cord-005453-4057qib7 12963 53 generation generation NN cord-005453-4057qib7 12963 54 CAR car NN cord-005453-4057qib7 12963 55 retroviral retroviral NN cord-005453-4057qib7 12963 56 vector vector NN cord-005453-4057qib7 12963 57 ( ( -LRB- cord-005453-4057qib7 12963 58 RV rv NN cord-005453-4057qib7 12963 59 - - HYPH cord-005453-4057qib7 12963 60 SFG.CD19.CD28.4 SFG.CD19.CD28.4 NNP cord-005453-4057qib7 12963 61 - - HYPH cord-005453-4057qib7 12963 62 1BBzeta 1bbzeta CD cord-005453-4057qib7 12963 63 ) ) -RRB- cord-005453-4057qib7 12963 64 targeting target VBG cord-005453-4057qib7 12963 65 CD19 CD19 NNP cord-005453-4057qib7 12963 66 . . . cord-005453-4057qib7 12964 1 The the DT cord-005453-4057qib7 12964 2 main main JJ cord-005453-4057qib7 12964 3 purpose purpose NN cord-005453-4057qib7 12964 4 of of IN cord-005453-4057qib7 12964 5 HD HD NNP cord-005453-4057qib7 12964 6 - - HYPH cord-005453-4057qib7 12964 7 CAR-1 CAR-1 NNP cord-005453-4057qib7 12964 8 is be VBZ cord-005453-4057qib7 12964 9 to to TO cord-005453-4057qib7 12964 10 evaluate evaluate VB cord-005453-4057qib7 12964 11 safety safety NN cord-005453-4057qib7 12964 12 and and CC cord-005453-4057qib7 12964 13 feasibility feasibility NN cord-005453-4057qib7 12964 14 of of IN cord-005453-4057qib7 12964 15 escalating escalate VBG cord-005453-4057qib7 12964 16 third third JJ cord-005453-4057qib7 12964 17 - - HYPH cord-005453-4057qib7 12964 18 generation generation NN cord-005453-4057qib7 12964 19 CAR car NN cord-005453-4057qib7 12964 20 T t NN cord-005453-4057qib7 12964 21 cell cell NN cord-005453-4057qib7 12964 22 doses dose NNS cord-005453-4057qib7 12964 23 ( ( -LRB- cord-005453-4057qib7 12964 24 1 1 CD cord-005453-4057qib7 12964 25 - - SYM cord-005453-4057qib7 12964 26 20×10 20×10 CD cord-005453-4057qib7 12964 27 6 6 CD cord-005453-4057qib7 12964 28 transduced transduce VBN cord-005453-4057qib7 12964 29 cells cell NNS cord-005453-4057qib7 12964 30 / / SYM cord-005453-4057qib7 12964 31 m m CD cord-005453-4057qib7 12964 32 2 2 CD cord-005453-4057qib7 12964 33 ) ) -RRB- cord-005453-4057qib7 12964 34 after after IN cord-005453-4057qib7 12964 35 lymphodepletion lymphodepletion NN cord-005453-4057qib7 12964 36 with with IN cord-005453-4057qib7 12964 37 fludarabine fludarabine NN cord-005453-4057qib7 12964 38 and and CC cord-005453-4057qib7 12964 39 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 12964 40 . . . cord-005453-4057qib7 12965 1 Patients patient NNS cord-005453-4057qib7 12965 2 are be VBP cord-005453-4057qib7 12965 3 monitored monitor VBN cord-005453-4057qib7 12965 4 for for IN cord-005453-4057qib7 12965 5 cytokine cytokine NN cord-005453-4057qib7 12965 6 release release NN cord-005453-4057qib7 12965 7 syndrome syndrome NN cord-005453-4057qib7 12965 8 ( ( -LRB- cord-005453-4057qib7 12965 9 CRS CRS NNP cord-005453-4057qib7 12965 10 ) ) -RRB- cord-005453-4057qib7 12965 11 , , , cord-005453-4057qib7 12965 12 CAR car NN cord-005453-4057qib7 12965 13 - - HYPH cord-005453-4057qib7 12965 14 T t NN cord-005453-4057qib7 12965 15 - - HYPH cord-005453-4057qib7 12965 16 cell cell NN cord-005453-4057qib7 12965 17 related relate VBN cord-005453-4057qib7 12965 18 encephalopathy encephalopathy NN cord-005453-4057qib7 12965 19 syndrome syndrome NN cord-005453-4057qib7 12965 20 ( ( -LRB- cord-005453-4057qib7 12965 21 CRES CRES NNP cord-005453-4057qib7 12965 22 ) ) -RRB- cord-005453-4057qib7 12966 1 and/or and/or CC cord-005453-4057qib7 12966 2 other other JJ cord-005453-4057qib7 12966 3 toxicities toxicity NNS cord-005453-4057qib7 12966 4 . . . cord-005453-4057qib7 12967 1 In in IN cord-005453-4057qib7 12967 2 vivo vivo NN cord-005453-4057qib7 12967 3 function function NN cord-005453-4057qib7 12967 4 , , , cord-005453-4057qib7 12967 5 survival survival NN cord-005453-4057qib7 12967 6 and and CC cord-005453-4057qib7 12967 7 anti anti JJ cord-005453-4057qib7 12967 8 - - JJ cord-005453-4057qib7 12967 9 tumor tumor JJ cord-005453-4057qib7 12967 10 efficacy efficacy NN cord-005453-4057qib7 12967 11 of of IN cord-005453-4057qib7 12967 12 CARTs cart NNS cord-005453-4057qib7 12967 13 are be VBP cord-005453-4057qib7 12967 14 assessed assess VBN cord-005453-4057qib7 12967 15 . . . cord-005453-4057qib7 12968 1 Results result NNS cord-005453-4057qib7 12968 2 : : : cord-005453-4057qib7 12969 1 To to IN cord-005453-4057qib7 12969 2 date date NN cord-005453-4057qib7 12969 3 , , , cord-005453-4057qib7 12969 4 three three CD cord-005453-4057qib7 12969 5 patients patient NNS cord-005453-4057qib7 12969 6 ( ( -LRB- cord-005453-4057qib7 12969 7 CLL CLL NNP cord-005453-4057qib7 12969 8 , , , cord-005453-4057qib7 12969 9 DLBCL DLBCL NNP cord-005453-4057qib7 12969 10 and and CC cord-005453-4057qib7 12969 11 MCL MCL NNP cord-005453-4057qib7 12969 12 , , , cord-005453-4057qib7 12969 13 respectively respectively RB cord-005453-4057qib7 12969 14 ) ) -RRB- cord-005453-4057qib7 12969 15 have have VBP cord-005453-4057qib7 12969 16 been be VBN cord-005453-4057qib7 12969 17 enrolled enrol VBN cord-005453-4057qib7 12969 18 and and CC cord-005453-4057qib7 12969 19 subjected subject VBN cord-005453-4057qib7 12969 20 to to IN cord-005453-4057qib7 12969 21 leukapheresis leukapheresis NN cord-005453-4057qib7 12969 22 . . . cord-005453-4057qib7 12970 1 High high JJ cord-005453-4057qib7 12970 2 numbers number NNS cord-005453-4057qib7 12970 3 of of IN cord-005453-4057qib7 12970 4 transduced transduce VBN cord-005453-4057qib7 12970 5 CARTs cart NNS cord-005453-4057qib7 12970 6 were be VBD cord-005453-4057qib7 12970 7 harvested harvest VBN cord-005453-4057qib7 12970 8 on on IN cord-005453-4057qib7 12970 9 day day NN cord-005453-4057qib7 12970 10 10 10 CD cord-005453-4057qib7 12970 11 of of IN cord-005453-4057qib7 12970 12 culture culture NN cord-005453-4057qib7 12970 13 ( ( -LRB- cord-005453-4057qib7 12970 14 82 82 CD cord-005453-4057qib7 12970 15 - - HYPH cord-005453-4057qib7 12970 16 123x10 123x10 CD cord-005453-4057qib7 12970 17 6 6 CD cord-005453-4057qib7 12970 18 CARTs cart NNS cord-005453-4057qib7 12970 19 ) ) -RRB- cord-005453-4057qib7 12970 20 . . . cord-005453-4057qib7 12971 1 Transduction transduction NN cord-005453-4057qib7 12971 2 efficiency efficiency NN cord-005453-4057qib7 12971 3 ranged range VBD cord-005453-4057qib7 12971 4 between between IN cord-005453-4057qib7 12971 5 33 33 CD cord-005453-4057qib7 12971 6 and and CC cord-005453-4057qib7 12971 7 42 42 CD cord-005453-4057qib7 12971 8 % % NN cord-005453-4057qib7 12971 9 . . . cord-005453-4057qib7 12972 1 CART cart NN cord-005453-4057qib7 12972 2 products product NNS cord-005453-4057qib7 12972 3 were be VBD cord-005453-4057qib7 12972 4 sterile sterile JJ cord-005453-4057qib7 12972 5 and and CC cord-005453-4057qib7 12972 6 free free JJ cord-005453-4057qib7 12972 7 from from IN cord-005453-4057qib7 12972 8 mycoplasms mycoplasm NNS cord-005453-4057qib7 12972 9 and and CC cord-005453-4057qib7 12972 10 endotoxins endotoxin NNS cord-005453-4057qib7 12972 11 . . . cord-005453-4057qib7 12973 1 No no DT cord-005453-4057qib7 12973 2 production production NN cord-005453-4057qib7 12973 3 failure failure NN cord-005453-4057qib7 12973 4 occurred occur VBD cord-005453-4057qib7 12973 5 and and CC cord-005453-4057qib7 12973 6 all all DT cord-005453-4057qib7 12973 7 patients patient NNS cord-005453-4057qib7 12973 8 received receive VBD cord-005453-4057qib7 12973 9 the the DT cord-005453-4057qib7 12973 10 CART cart NN cord-005453-4057qib7 12973 11 product product NN cord-005453-4057qib7 12973 12 . . . cord-005453-4057qib7 12974 1 No no DT cord-005453-4057qib7 12974 2 signs sign NNS cord-005453-4057qib7 12974 3 of of IN cord-005453-4057qib7 12974 4 CRS CRS NNP cord-005453-4057qib7 12974 5 or or CC cord-005453-4057qib7 12974 6 CRES CRES NNP cord-005453-4057qib7 12974 7 > > XX cord-005453-4057qib7 12975 1 grade grade NN cord-005453-4057qib7 12975 2 2 2 CD cord-005453-4057qib7 12975 3 have have VBP cord-005453-4057qib7 12975 4 been be VBN cord-005453-4057qib7 12975 5 observed observe VBN cord-005453-4057qib7 12975 6 . . . cord-005453-4057qib7 12976 1 Assessments assessment NNS cord-005453-4057qib7 12976 2 of of IN cord-005453-4057qib7 12976 3 clinical clinical JJ cord-005453-4057qib7 12976 4 responses response NNS cord-005453-4057qib7 12976 5 are be VBP cord-005453-4057qib7 12976 6 pending pende VBG cord-005453-4057qib7 12976 7 and and CC cord-005453-4057qib7 12976 8 will will MD cord-005453-4057qib7 12976 9 be be VB cord-005453-4057qib7 12976 10 presented present VBN cord-005453-4057qib7 12976 11 at at IN cord-005453-4057qib7 12976 12 the the DT cord-005453-4057qib7 12976 13 conference conference NN cord-005453-4057qib7 12976 14 along along IN cord-005453-4057qib7 12976 15 with with IN cord-005453-4057qib7 12976 16 updated update VBN cord-005453-4057qib7 12976 17 technical technical JJ cord-005453-4057qib7 12976 18 results result NNS cord-005453-4057qib7 12976 19 . . . cord-005453-4057qib7 12977 1 Conclusions conclusion NNS cord-005453-4057qib7 12977 2 : : : cord-005453-4057qib7 12978 1 For for IN cord-005453-4057qib7 12978 2 HD HD NNP cord-005453-4057qib7 12978 3 - - HYPH cord-005453-4057qib7 12978 4 CAR-1 CAR-1 NNP cord-005453-4057qib7 12978 5 , , , cord-005453-4057qib7 12978 6 GMP GMP NNP cord-005453-4057qib7 12978 7 - - HYPH cord-005453-4057qib7 12978 8 conform conform VBP cord-005453-4057qib7 12978 9 leukapheresis leukapheresis NN cord-005453-4057qib7 12978 10 as as RB cord-005453-4057qib7 12978 11 well well RB cord-005453-4057qib7 12978 12 as as IN cord-005453-4057qib7 12978 13 CART cart NN cord-005453-4057qib7 12978 14 manufacturing manufacturing NN cord-005453-4057qib7 12978 15 was be VBD cord-005453-4057qib7 12978 16 effective effective JJ cord-005453-4057qib7 12978 17 . . . cord-005453-4057qib7 12979 1 Administration administration NN cord-005453-4057qib7 12979 2 , , , cord-005453-4057qib7 12979 3 patient patient JJ cord-005453-4057qib7 12979 4 monitoring monitoring NN cord-005453-4057qib7 12979 5 and and CC cord-005453-4057qib7 12979 6 follow follow NN cord-005453-4057qib7 12979 7 - - HYPH cord-005453-4057qib7 12979 8 up up NN cord-005453-4057qib7 12979 9 were be VBD cord-005453-4057qib7 12979 10 performed perform VBN cord-005453-4057qib7 12979 11 in in IN cord-005453-4057qib7 12979 12 - - HYPH cord-005453-4057qib7 12979 13 house house NN cord-005453-4057qib7 12979 14 providing provide VBG cord-005453-4057qib7 12979 15 independency independency NN cord-005453-4057qib7 12979 16 from from IN cord-005453-4057qib7 12979 17 transport transport NN cord-005453-4057qib7 12979 18 or or CC cord-005453-4057qib7 12979 19 production production NN cord-005453-4057qib7 12979 20 sites site NNS cord-005453-4057qib7 12979 21 outside outside IN cord-005453-4057qib7 12979 22 the the DT cord-005453-4057qib7 12979 23 University University NNP cord-005453-4057qib7 12979 24 Hospital Hospital NNP cord-005453-4057qib7 12979 25 Heidelberg Heidelberg NNP cord-005453-4057qib7 12979 26 , , , cord-005453-4057qib7 12979 27 altogether altogether RB cord-005453-4057qib7 12979 28 suggesting suggest VBG cord-005453-4057qib7 12979 29 that that IN cord-005453-4057qib7 12979 30 academic academic JJ cord-005453-4057qib7 12979 31 CART CART NNP cord-005453-4057qib7 12979 32 IITs IITs NNPS cord-005453-4057qib7 12979 33 are be VBP cord-005453-4057qib7 12979 34 feasible feasible JJ cord-005453-4057qib7 12979 35 in in IN cord-005453-4057qib7 12979 36 Germany Germany NNP cord-005453-4057qib7 12979 37 . . . cord-005453-4057qib7 12980 1 Clinical clinical JJ cord-005453-4057qib7 12980 2 Background background NN cord-005453-4057qib7 12980 3 : : : cord-005453-4057qib7 12981 1 The the DT cord-005453-4057qib7 12981 2 prognosis prognosis NN cord-005453-4057qib7 12981 3 of of IN cord-005453-4057qib7 12981 4 adult adult NN cord-005453-4057qib7 12981 5 patients patient NNS cord-005453-4057qib7 12981 6 ( ( -LRB- cord-005453-4057qib7 12981 7 pts pt NNS cord-005453-4057qib7 12981 8 ) ) -RRB- cord-005453-4057qib7 12981 9 with with IN cord-005453-4057qib7 12981 10 relapsed relapse VBN cord-005453-4057qib7 12981 11 / / SYM cord-005453-4057qib7 12981 12 refractory refractory NN cord-005453-4057qib7 12981 13 ( ( -LRB- cord-005453-4057qib7 12981 14 R r NN cord-005453-4057qib7 12981 15 / / SYM cord-005453-4057qib7 12981 16 R r NN cord-005453-4057qib7 12981 17 ) ) -RRB- cord-005453-4057qib7 12981 18 precursor precursor NN cord-005453-4057qib7 12981 19 B b NN cord-005453-4057qib7 12981 20 - - HYPH cord-005453-4057qib7 12981 21 acute acute JJ cord-005453-4057qib7 12981 22 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 12981 23 leukemia leukemia NN cord-005453-4057qib7 12981 24 ( ( -LRB- cord-005453-4057qib7 12981 25 ALL all DT cord-005453-4057qib7 12981 26 ) ) -RRB- cord-005453-4057qib7 12981 27 is be VBZ cord-005453-4057qib7 12981 28 dismal dismal JJ cord-005453-4057qib7 12981 29 , , , cord-005453-4057qib7 12981 30 including include VBG cord-005453-4057qib7 12981 31 with with IN cord-005453-4057qib7 12981 32 allogeneic allogeneic JJ cord-005453-4057qib7 12981 33 hematopoietic hematopoietic JJ cord-005453-4057qib7 12981 34 stem stem NN cord-005453-4057qib7 12981 35 cell cell NN cord-005453-4057qib7 12981 36 transplantation transplantation NN cord-005453-4057qib7 12981 37 ( ( -LRB- cord-005453-4057qib7 12981 38 allo allo NN cord-005453-4057qib7 12981 39 - - HYPH cord-005453-4057qib7 12981 40 HSCT HSCT NNP cord-005453-4057qib7 12981 41 ) ) -RRB- cord-005453-4057qib7 12981 42 . . . cord-005453-4057qib7 12982 1 Blinatumomab Blinatumomab NNP cord-005453-4057qib7 12982 2 , , , cord-005453-4057qib7 12982 3 a a DT cord-005453-4057qib7 12982 4 bispecific bispecific NN cord-005453-4057qib7 12982 5 CD19-directed cd19-directe VBN cord-005453-4057qib7 12982 6 CD3 CD3 NNP cord-005453-4057qib7 12982 7 T T NNP cord-005453-4057qib7 12982 8 - - HYPH cord-005453-4057qib7 12982 9 cell cell NN cord-005453-4057qib7 12982 10 engager engager NN cord-005453-4057qib7 12982 11 and and CC cord-005453-4057qib7 12982 12 inotuzumab inotuzumab NNP cord-005453-4057qib7 12982 13 ozogamycin ozogamycin NNP cord-005453-4057qib7 12982 14 ( ( -LRB- cord-005453-4057qib7 12982 15 IO IO NNP cord-005453-4057qib7 12982 16 ) ) -RRB- cord-005453-4057qib7 12982 17 , , , cord-005453-4057qib7 12982 18 a a DT cord-005453-4057qib7 12982 19 CD22-directed cd22-directe VBN cord-005453-4057qib7 12982 20 antibody antibody NN cord-005453-4057qib7 12982 21 - - HYPH cord-005453-4057qib7 12982 22 drug drug NN cord-005453-4057qib7 12982 23 conjugate conjugate NN cord-005453-4057qib7 12982 24 revolutionized revolutionize VBD cord-005453-4057qib7 12982 25 the the DT cord-005453-4057qib7 12982 26 field field NN cord-005453-4057qib7 12982 27 , , , cord-005453-4057qib7 12982 28 improving improve VBG cord-005453-4057qib7 12982 29 their -PRON- PRP$ cord-005453-4057qib7 12982 30 outcomes outcome NNS cord-005453-4057qib7 12982 31 . . . cord-005453-4057qib7 12983 1 Anti Anti NNP cord-005453-4057qib7 12983 2 - - JJ cord-005453-4057qib7 12983 3 CD19 cd19 JJ cord-005453-4057qib7 12983 4 chimeric chimeric JJ cord-005453-4057qib7 12983 5 antigen antigen NN cord-005453-4057qib7 12983 6 receptor receptor NN cord-005453-4057qib7 12983 7 T T NNP cord-005453-4057qib7 12983 8 ( ( -LRB- cord-005453-4057qib7 12983 9 CART cart NN cord-005453-4057qib7 12983 10 ) ) -RRB- cord-005453-4057qib7 12983 11 cell cell NN cord-005453-4057qib7 12983 12 therapy therapy NN cord-005453-4057qib7 12983 13 has have VBZ cord-005453-4057qib7 12983 14 led lead VBN cord-005453-4057qib7 12983 15 to to IN cord-005453-4057qib7 12983 16 further further JJ cord-005453-4057qib7 12983 17 progress progress NN cord-005453-4057qib7 12983 18 and and CC cord-005453-4057qib7 12983 19 improved improved JJ cord-005453-4057qib7 12983 20 outcome outcome NN cord-005453-4057qib7 12983 21 ( ( -LRB- cord-005453-4057qib7 12983 22 Jacoby Jacoby NNP cord-005453-4057qib7 12983 23 E E NNP cord-005453-4057qib7 12983 24 ; ; : cord-005453-4057qib7 12983 25 Am be VBP cord-005453-4057qib7 12983 26 J J NNP cord-005453-4057qib7 12983 27 Hematol Hematol NNP cord-005453-4057qib7 12983 28 , , , cord-005453-4057qib7 12983 29 2018 2018 CD cord-005453-4057qib7 12983 30 ) ) -RRB- cord-005453-4057qib7 12983 31 . . . cord-005453-4057qib7 12984 1 Nowadays nowadays RB cord-005453-4057qib7 12984 2 , , , cord-005453-4057qib7 12984 3 patients patient NNS cord-005453-4057qib7 12984 4 with with IN cord-005453-4057qib7 12984 5 R r NN cord-005453-4057qib7 12984 6 / / SYM cord-005453-4057qib7 12984 7 R r NN cord-005453-4057qib7 12984 8 B b NN cord-005453-4057qib7 12984 9 - - : cord-005453-4057qib7 12984 10 ALL all DT cord-005453-4057qib7 12984 11 can can MD cord-005453-4057qib7 12984 12 be be VB cord-005453-4057qib7 12984 13 offered offer VBN cord-005453-4057qib7 12984 14 both both DT cord-005453-4057qib7 12984 15 therapies therapy NNS cord-005453-4057qib7 12984 16 , , , cord-005453-4057qib7 12984 17 but but CC cord-005453-4057qib7 12984 18 there there EX cord-005453-4057qib7 12984 19 are be VBP cord-005453-4057qib7 12984 20 limited limited JJ cord-005453-4057qib7 12984 21 data datum NNS cord-005453-4057qib7 12984 22 on on IN cord-005453-4057qib7 12984 23 the the DT cord-005453-4057qib7 12984 24 safety safety NN cord-005453-4057qib7 12984 25 and and CC cord-005453-4057qib7 12984 26 efficacy efficacy NN cord-005453-4057qib7 12984 27 of of IN cord-005453-4057qib7 12984 28 CART CART NNP cord-005453-4057qib7 12984 29 -cell -cell CD cord-005453-4057qib7 12984 30 therapy therapy NN cord-005453-4057qib7 12984 31 post post NN cord-005453-4057qib7 12984 32 antibody antibody NN cord-005453-4057qib7 12984 33 treatment treatment NN cord-005453-4057qib7 12984 34 . . . cord-005453-4057qib7 12985 1 We -PRON- PRP cord-005453-4057qib7 12985 2 detailed detail VBD cord-005453-4057qib7 12985 3 our -PRON- PRP$ cord-005453-4057qib7 12985 4 single single JJ cord-005453-4057qib7 12985 5 center center NN cord-005453-4057qib7 12985 6 experience experience NN cord-005453-4057qib7 12985 7 in in IN cord-005453-4057qib7 12985 8 this this DT cord-005453-4057qib7 12985 9 regard regard NN cord-005453-4057qib7 12985 10 . . . cord-005453-4057qib7 12986 1 Methods method NNS cord-005453-4057qib7 12986 2 : : : cord-005453-4057qib7 12986 3 This this DT cord-005453-4057qib7 12986 4 report report NN cord-005453-4057qib7 12986 5 is be VBZ cord-005453-4057qib7 12986 6 a a DT cord-005453-4057qib7 12986 7 part part NN cord-005453-4057qib7 12986 8 of of IN cord-005453-4057qib7 12986 9 a a DT cord-005453-4057qib7 12986 10 single single JJ cord-005453-4057qib7 12986 11 center center NN cord-005453-4057qib7 12986 12 , , , cord-005453-4057qib7 12986 13 phase phase NN cord-005453-4057qib7 12986 14 1b/2 1b/2 CD cord-005453-4057qib7 12986 15 study study NN cord-005453-4057qib7 12986 16 on on IN cord-005453-4057qib7 12986 17 therapy therapy NN cord-005453-4057qib7 12986 18 of of IN cord-005453-4057qib7 12986 19 B b NN cord-005453-4057qib7 12986 20 - - HYPH cord-005453-4057qib7 12986 21 cell cell NN cord-005453-4057qib7 12986 22 malignancies malignancy NNS cord-005453-4057qib7 12986 23 with with IN cord-005453-4057qib7 12986 24 locally locally RB cord-005453-4057qib7 12986 25 produced produce VBN cord-005453-4057qib7 12986 26 CART cart NN cord-005453-4057qib7 12986 27 - - HYPH cord-005453-4057qib7 12986 28 cells cell NNS cord-005453-4057qib7 12986 29 ( ( -LRB- cord-005453-4057qib7 12986 30 NCT02772198 NCT02772198 NNP cord-005453-4057qib7 12986 31 ) ) -RRB- cord-005453-4057qib7 12986 32 . . . cord-005453-4057qib7 12987 1 The the DT cord-005453-4057qib7 12987 2 approach approach NN cord-005453-4057qib7 12987 3 uses use VBZ cord-005453-4057qib7 12987 4 autologous autologous JJ cord-005453-4057qib7 12987 5 T t NN cord-005453-4057qib7 12987 6 cells cell NNS cord-005453-4057qib7 12987 7 with with IN cord-005453-4057qib7 12987 8 CAR car NN cord-005453-4057qib7 12987 9 construct construct NN cord-005453-4057qib7 12987 10 that that WDT cord-005453-4057qib7 12987 11 is be VBZ cord-005453-4057qib7 12987 12 composed compose VBN cord-005453-4057qib7 12987 13 of of IN cord-005453-4057qib7 12987 14 an an DT cord-005453-4057qib7 12987 15 anti anti JJ cord-005453-4057qib7 12987 16 - - JJ cord-005453-4057qib7 12987 17 CD19 cd19 JJ cord-005453-4057qib7 12987 18 single single JJ cord-005453-4057qib7 12987 19 - - HYPH cord-005453-4057qib7 12987 20 chain chain NN cord-005453-4057qib7 12987 21 Fv Fv NNP cord-005453-4057qib7 12987 22 , , , cord-005453-4057qib7 12987 23 CD28 CD28 NNP cord-005453-4057qib7 12987 24 co co NN cord-005453-4057qib7 12987 25 - - JJ cord-005453-4057qib7 12987 26 stimulatory stimulatory JJ cord-005453-4057qib7 12987 27 and and CC cord-005453-4057qib7 12987 28 CD3-zeta cd3-zeta JJ cord-005453-4057qib7 12987 29 intracellular intracellular JJ cord-005453-4057qib7 12987 30 domains domain NNS cord-005453-4057qib7 12987 31 . . . cord-005453-4057qib7 12988 1 CD19 cd19 JJ cord-005453-4057qib7 12988 2 expression expression NN cord-005453-4057qib7 12988 3 on on IN cord-005453-4057qib7 12988 4 the the DT cord-005453-4057qib7 12988 5 blasts blast NNS cord-005453-4057qib7 12988 6 was be VBD cord-005453-4057qib7 12988 7 documented document VBN cord-005453-4057qib7 12988 8 prior prior JJ cord-005453-4057qib7 12988 9 treatment treatment NN cord-005453-4057qib7 12988 10 in in IN cord-005453-4057qib7 12988 11 all all DT cord-005453-4057qib7 12988 12 pts pt NNS cord-005453-4057qib7 12988 13 by by IN cord-005453-4057qib7 12988 14 flow flow NN cord-005453-4057qib7 12988 15 cytometry cytometry NN cord-005453-4057qib7 12988 16 . . . cord-005453-4057qib7 12989 1 All all DT cord-005453-4057qib7 12989 2 pts pt NNS cord-005453-4057qib7 12989 3 received receive VBD cord-005453-4057qib7 12989 4 1 1 CD cord-005453-4057qib7 12989 5 x x SYM cord-005453-4057qib7 12989 6 10 10 CD cord-005453-4057qib7 12989 7 6 6 CD cord-005453-4057qib7 12989 8 /kg /kg CD cord-005453-4057qib7 12989 9 CART cart NN cord-005453-4057qib7 12989 10 - - HYPH cord-005453-4057qib7 12989 11 cells cell NNS cord-005453-4057qib7 12989 12 after after IN cord-005453-4057qib7 12989 13 lymphodepletion lymphodepletion NN cord-005453-4057qib7 12989 14 with with IN cord-005453-4057qib7 12989 15 fludarabin fludarabin NNP cord-005453-4057qib7 12989 16 and and CC cord-005453-4057qib7 12989 17 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 12989 18 . . . cord-005453-4057qib7 12990 1 Results result NNS cord-005453-4057qib7 12990 2 : : : cord-005453-4057qib7 12991 1 Six six CD cord-005453-4057qib7 12991 2 pts pt NNS cord-005453-4057qib7 12991 3 ( ( -LRB- cord-005453-4057qib7 12991 4 2 2 CD cord-005453-4057qib7 12991 5 Males Males NNPS cord-005453-4057qib7 12991 6 and and CC cord-005453-4057qib7 12991 7 4 4 CD cord-005453-4057qib7 12991 8 Females female NNS cord-005453-4057qib7 12991 9 ) ) -RRB- cord-005453-4057qib7 12991 10 with with IN cord-005453-4057qib7 12991 11 R r NN cord-005453-4057qib7 12991 12 / / SYM cord-005453-4057qib7 12991 13 R r NN cord-005453-4057qib7 12991 14 B b NN cord-005453-4057qib7 12991 15 - - : cord-005453-4057qib7 12991 16 ALL all DT cord-005453-4057qib7 12991 17 were be VBD cord-005453-4057qib7 12991 18 enrolled enrol VBN cord-005453-4057qib7 12991 19 , , , cord-005453-4057qib7 12991 20 including include VBG cord-005453-4057qib7 12991 21 one one CD cord-005453-4057qib7 12991 22 with with IN cord-005453-4057qib7 12991 23 Ph Ph NNP cord-005453-4057qib7 12991 24 - - JJ cord-005453-4057qib7 12991 25 positive positive JJ cord-005453-4057qib7 12991 26 B b NN cord-005453-4057qib7 12991 27 - - : cord-005453-4057qib7 12991 28 ALL all DT cord-005453-4057qib7 12991 29 . . . cord-005453-4057qib7 12992 1 The the DT cord-005453-4057qib7 12992 2 median median JJ cord-005453-4057qib7 12992 3 age age NN cord-005453-4057qib7 12992 4 was be VBD cord-005453-4057qib7 12992 5 42 42 CD cord-005453-4057qib7 12992 6 years year NNS cord-005453-4057qib7 12992 7 ( ( -LRB- cord-005453-4057qib7 12992 8 25 25 CD cord-005453-4057qib7 12992 9 - - SYM cord-005453-4057qib7 12992 10 59 59 CD cord-005453-4057qib7 12992 11 ) ) -RRB- cord-005453-4057qib7 12992 12 . . . cord-005453-4057qib7 12993 1 Median median JJ cord-005453-4057qib7 12993 2 number number NN cord-005453-4057qib7 12993 3 of of IN cord-005453-4057qib7 12993 4 prior prior JJ cord-005453-4057qib7 12993 5 therapy therapy NN cord-005453-4057qib7 12993 6 was be VBD cord-005453-4057qib7 12993 7 4 4 CD cord-005453-4057qib7 12993 8 ( ( -LRB- cord-005453-4057qib7 12993 9 3 3 CD cord-005453-4057qib7 12993 10 ) ) -RRB- cord-005453-4057qib7 12993 11 ( ( -LRB- cord-005453-4057qib7 12993 12 4 4 LS cord-005453-4057qib7 12993 13 ) ) -RRB- cord-005453-4057qib7 12993 14 ( ( -LRB- cord-005453-4057qib7 12993 15 5 5 CD cord-005453-4057qib7 12993 16 ) ) -RRB- cord-005453-4057qib7 12993 17 . . . cord-005453-4057qib7 12994 1 Five five CD cord-005453-4057qib7 12994 2 pts pt NNS cord-005453-4057qib7 12994 3 had have VBD cord-005453-4057qib7 12994 4 prior prior JJ cord-005453-4057qib7 12994 5 allo allo NN cord-005453-4057qib7 12994 6 - - HYPH cord-005453-4057qib7 12994 7 HSCT HSCT NNP cord-005453-4057qib7 12994 8 . . . cord-005453-4057qib7 12995 1 Four four CD cord-005453-4057qib7 12995 2 pts pt NNS cord-005453-4057qib7 12995 3 were be VBD cord-005453-4057qib7 12995 4 given give VBN cord-005453-4057qib7 12995 5 antibodies antibody NNS cord-005453-4057qib7 12995 6 as as IN cord-005453-4057qib7 12995 7 the the DT cord-005453-4057qib7 12995 8 last last JJ cord-005453-4057qib7 12995 9 therapy therapy NN cord-005453-4057qib7 12995 10 prior prior RB cord-005453-4057qib7 12995 11 to to IN cord-005453-4057qib7 12995 12 CART cart NN cord-005453-4057qib7 12995 13 cells cell NNS cord-005453-4057qib7 12995 14 . . . cord-005453-4057qib7 12996 1 Two two CD cord-005453-4057qib7 12996 2 pts pt NNS cord-005453-4057qib7 12996 3 received receive VBN cord-005453-4057qib7 12996 4 blinatumomab blinatumomab NN cord-005453-4057qib7 12996 5 resulting result VBG cord-005453-4057qib7 12996 6 in in IN cord-005453-4057qib7 12996 7 PR PR NNP cord-005453-4057qib7 12996 8 in in IN cord-005453-4057qib7 12996 9 one one CD cord-005453-4057qib7 12996 10 of of IN cord-005453-4057qib7 12996 11 them -PRON- PRP cord-005453-4057qib7 12996 12 . . . cord-005453-4057qib7 12997 1 Two two CD cord-005453-4057qib7 12997 2 additional additional JJ cord-005453-4057qib7 12997 3 pts pt NNS cord-005453-4057qib7 12997 4 received receive VBD cord-005453-4057qib7 12997 5 IO IO NNP cord-005453-4057qib7 12997 6 ( ( -LRB- cord-005453-4057qib7 12997 7 1 1 CD cord-005453-4057qib7 12997 8 after after IN cord-005453-4057qib7 12997 9 failing fail VBG cord-005453-4057qib7 12997 10 blinatumomab blinatumomab NNS cord-005453-4057qib7 12997 11 ) ) -RRB- cord-005453-4057qib7 12997 12 achieving achieve VBG cord-005453-4057qib7 12997 13 MRDpositive mrdpositive JJ cord-005453-4057qib7 12997 14 CR CR NNP cord-005453-4057qib7 12997 15 . . . cord-005453-4057qib7 12998 1 Cytokine cytokine NN cord-005453-4057qib7 12998 2 release release NN cord-005453-4057qib7 12998 3 syndrome syndrome NN cord-005453-4057qib7 12998 4 occurred occur VBD cord-005453-4057qib7 12998 5 in in IN cord-005453-4057qib7 12998 6 all all DT cord-005453-4057qib7 12998 7 pts pt NNS cord-005453-4057qib7 12998 8 and and CC cord-005453-4057qib7 12998 9 was be VBD cord-005453-4057qib7 12998 10 severe severe JJ cord-005453-4057qib7 12998 11 in in IN cord-005453-4057qib7 12998 12 only only RB cord-005453-4057qib7 12998 13 one one CD cord-005453-4057qib7 12998 14 patient patient NN cord-005453-4057qib7 12998 15 who who WP cord-005453-4057qib7 12998 16 required require VBD cord-005453-4057qib7 12998 17 tocilizumab tocilizumab JJ cord-005453-4057qib7 12998 18 treatment treatment NN cord-005453-4057qib7 12998 19 . . . cord-005453-4057qib7 12999 1 This this DT cord-005453-4057qib7 12999 2 patient patient NN cord-005453-4057qib7 12999 3 was be VBD cord-005453-4057qib7 12999 4 also also RB cord-005453-4057qib7 12999 5 the the DT cord-005453-4057qib7 12999 6 only only JJ cord-005453-4057qib7 12999 7 patient patient NN cord-005453-4057qib7 12999 8 who who WP cord-005453-4057qib7 12999 9 experienced experience VBD cord-005453-4057qib7 12999 10 neurotoxicity neurotoxicity NN cord-005453-4057qib7 12999 11 ( ( -LRB- cord-005453-4057qib7 12999 12 grade grade NN cord-005453-4057qib7 12999 13 3 3 CD cord-005453-4057qib7 12999 14 ) ) -RRB- cord-005453-4057qib7 12999 15 , , , cord-005453-4057qib7 12999 16 and and CC cord-005453-4057qib7 12999 17 was be VBD cord-005453-4057qib7 12999 18 treated treat VBN cord-005453-4057qib7 12999 19 with with IN cord-005453-4057qib7 12999 20 dexamethasone dexamethasone NN cord-005453-4057qib7 12999 21 . . . cord-005453-4057qib7 13000 1 This this DT cord-005453-4057qib7 13000 2 patient patient NN cord-005453-4057qib7 13000 3 eventually eventually RB cord-005453-4057qib7 13000 4 died die VBD cord-005453-4057qib7 13000 5 18 18 CD cord-005453-4057qib7 13000 6 days day NNS cord-005453-4057qib7 13000 7 post post NN cord-005453-4057qib7 13000 8 infusion infusion NN cord-005453-4057qib7 13000 9 of of IN cord-005453-4057qib7 13000 10 CART cart NN cord-005453-4057qib7 13000 11 cells cell NNS cord-005453-4057qib7 13000 12 due due JJ cord-005453-4057qib7 13000 13 to to IN cord-005453-4057qib7 13000 14 severe severe JJ cord-005453-4057qib7 13000 15 pseudomembranous pseudomembranous JJ cord-005453-4057qib7 13000 16 colitis colitis NN cord-005453-4057qib7 13000 17 , , , cord-005453-4057qib7 13000 18 toxic toxic JJ cord-005453-4057qib7 13000 19 megacolon megacolon NN cord-005453-4057qib7 13000 20 and and CC cord-005453-4057qib7 13000 21 sepsis sepsis NN cord-005453-4057qib7 13000 22 . . . cord-005453-4057qib7 13001 1 All all DT cord-005453-4057qib7 13001 2 pts pt NNS cord-005453-4057qib7 13001 3 had have VBD cord-005453-4057qib7 13001 4 prolonged prolong VBN cord-005453-4057qib7 13001 5 neutropenia neutropenia NN cord-005453-4057qib7 13001 6 for for IN cord-005453-4057qib7 13001 7 a a DT cord-005453-4057qib7 13001 8 median median NN cord-005453-4057qib7 13001 9 of of IN cord-005453-4057qib7 13001 10 14 14 CD cord-005453-4057qib7 13001 11 days day NNS cord-005453-4057qib7 13001 12 ( ( -LRB- cord-005453-4057qib7 13001 13 12 12 CD cord-005453-4057qib7 13001 14 - - SYM cord-005453-4057qib7 13001 15 18 18 CD cord-005453-4057qib7 13001 16 ) ) -RRB- cord-005453-4057qib7 13001 17 after after IN cord-005453-4057qib7 13001 18 the the DT cord-005453-4057qib7 13001 19 infusion infusion NN cord-005453-4057qib7 13001 20 of of IN cord-005453-4057qib7 13001 21 CART cart NN cord-005453-4057qib7 13001 22 cells cell NNS cord-005453-4057qib7 13001 23 . . . cord-005453-4057qib7 13002 1 At at IN cord-005453-4057qib7 13002 2 day day NN cord-005453-4057qib7 13002 3 28 28 CD cord-005453-4057qib7 13002 4 after after IN cord-005453-4057qib7 13002 5 infusion infusion NN cord-005453-4057qib7 13002 6 of of IN cord-005453-4057qib7 13002 7 CART cart NN cord-005453-4057qib7 13002 8 - - HYPH cord-005453-4057qib7 13002 9 cells cell NNS cord-005453-4057qib7 13002 10 the the DT cord-005453-4057qib7 13002 11 CR cr NN cord-005453-4057qib7 13002 12 for for IN cord-005453-4057qib7 13002 13 the the DT cord-005453-4057qib7 13002 14 entire entire JJ cord-005453-4057qib7 13002 15 cohort cohort NN cord-005453-4057qib7 13002 16 was be VBD cord-005453-4057qib7 13002 17 67 67 CD cord-005453-4057qib7 13002 18 % % NN cord-005453-4057qib7 13002 19 : : : cord-005453-4057qib7 13002 20 three three CD cord-005453-4057qib7 13002 21 pts pt NNS cord-005453-4057qib7 13002 22 with with IN cord-005453-4057qib7 13002 23 MRD MRD NNP cord-005453-4057qib7 13002 24 - - HYPH cord-005453-4057qib7 13002 25 negative negative JJ cord-005453-4057qib7 13002 26 and and CC cord-005453-4057qib7 13002 27 one one CD cord-005453-4057qib7 13002 28 with with IN cord-005453-4057qib7 13002 29 MRD MRD NNP cord-005453-4057qib7 13002 30 - - HYPH cord-005453-4057qib7 13002 31 positive positive JJ cord-005453-4057qib7 13002 32 response response NN cord-005453-4057qib7 13002 33 . . . cord-005453-4057qib7 13003 1 Among among IN cord-005453-4057qib7 13003 2 the the DT cord-005453-4057qib7 13003 3 four four CD cord-005453-4057qib7 13003 4 pts pt NNS cord-005453-4057qib7 13003 5 who who WP cord-005453-4057qib7 13003 6 received receive VBD cord-005453-4057qib7 13003 7 antibodies antibody NNS cord-005453-4057qib7 13003 8 prior prior IN cord-005453-4057qib7 13003 9 the the DT cord-005453-4057qib7 13003 10 CART cart NN cord-005453-4057qib7 13003 11 - - HYPH cord-005453-4057qib7 13003 12 cells cell NNS cord-005453-4057qib7 13003 13 , , , cord-005453-4057qib7 13003 14 one one CD cord-005453-4057qib7 13003 15 patient patient NN cord-005453-4057qib7 13003 16 had have VBD cord-005453-4057qib7 13003 17 MRD MRD NNP cord-005453-4057qib7 13003 18 - - HYPH cord-005453-4057qib7 13003 19 positive positive JJ cord-005453-4057qib7 13003 20 and and CC cord-005453-4057qib7 13003 21 two two CD cord-005453-4057qib7 13003 22 pts pt NNS cord-005453-4057qib7 13003 23 had have VBD cord-005453-4057qib7 13003 24 MRD MRD NNP cord-005453-4057qib7 13003 25 - - HYPH cord-005453-4057qib7 13003 26 negative negative JJ cord-005453-4057qib7 13003 27 response response NN cord-005453-4057qib7 13003 28 . . . cord-005453-4057qib7 13004 1 The the DT cord-005453-4057qib7 13004 2 patient patient NN cord-005453-4057qib7 13004 3 with with IN cord-005453-4057qib7 13004 4 Ph Ph NNP cord-005453-4057qib7 13004 5 positive positive JJ cord-005453-4057qib7 13004 6 B b NN cord-005453-4057qib7 13004 7 - - : cord-005453-4057qib7 13004 8 ALL all DT cord-005453-4057qib7 13004 9 had have VBD cord-005453-4057qib7 13004 10 progressive progressive JJ cord-005453-4057qib7 13004 11 disease disease NN cord-005453-4057qib7 13004 12 during during IN cord-005453-4057qib7 13004 13 the the DT cord-005453-4057qib7 13004 14 treatment treatment NN cord-005453-4057qib7 13004 15 . . . cord-005453-4057qib7 13005 1 Two two CD cord-005453-4057qib7 13005 2 pts pt NNS cord-005453-4057qib7 13005 3 were be VBD cord-005453-4057qib7 13005 4 referred refer VBN cord-005453-4057qib7 13005 5 to to IN cord-005453-4057qib7 13005 6 second second JJ cord-005453-4057qib7 13005 7 allo allo NN cord-005453-4057qib7 13005 8 - - HYPH cord-005453-4057qib7 13005 9 HSCT HSCT NNP cord-005453-4057qib7 13005 10 from from IN cord-005453-4057qib7 13005 11 other other JJ cord-005453-4057qib7 13005 12 donors donor NNS cord-005453-4057qib7 13005 13 . . . cord-005453-4057qib7 13006 1 One one CD cord-005453-4057qib7 13006 2 patient patient NN cord-005453-4057qib7 13006 3 with with IN cord-005453-4057qib7 13006 4 MRD MRD NNP cord-005453-4057qib7 13006 5 - - HYPH cord-005453-4057qib7 13006 6 negative negative JJ cord-005453-4057qib7 13006 7 response response NN cord-005453-4057qib7 13006 8 relapsed relapse VBN cord-005453-4057qib7 13006 9 after after IN cord-005453-4057qib7 13006 10 the the DT cord-005453-4057qib7 13006 11 second second JJ cord-005453-4057qib7 13006 12 transplant transplant NN cord-005453-4057qib7 13006 13 and and CC cord-005453-4057qib7 13006 14 was be VBD cord-005453-4057qib7 13006 15 treated treat VBN cord-005453-4057qib7 13006 16 by by IN cord-005453-4057qib7 13006 17 salvage salvage NN cord-005453-4057qib7 13006 18 therapy therapy NN cord-005453-4057qib7 13006 19 . . . cord-005453-4057qib7 13007 1 The the DT cord-005453-4057qib7 13007 2 second second JJ cord-005453-4057qib7 13007 3 patient patient NN cord-005453-4057qib7 13007 4 with with IN cord-005453-4057qib7 13007 5 MRDnegative MRDnegative NNP cord-005453-4057qib7 13007 6 response response NN cord-005453-4057qib7 13007 7 demonstrated demonstrate VBD cord-005453-4057qib7 13007 8 prolonged prolonged JJ cord-005453-4057qib7 13007 9 remission remission NN cord-005453-4057qib7 13007 10 ( ( -LRB- cord-005453-4057qib7 13007 11 20 20 CD cord-005453-4057qib7 13007 12 months month NNS cord-005453-4057qib7 13007 13 ) ) -RRB- cord-005453-4057qib7 13007 14 even even RB cord-005453-4057qib7 13007 15 without without IN cord-005453-4057qib7 13007 16 second second JJ cord-005453-4057qib7 13007 17 transplantation transplantation NN cord-005453-4057qib7 13007 18 . . . cord-005453-4057qib7 13008 1 With with IN cord-005453-4057qib7 13008 2 a a DT cord-005453-4057qib7 13008 3 median median JJ cord-005453-4057qib7 13008 4 follow follow NN cord-005453-4057qib7 13008 5 - - HYPH cord-005453-4057qib7 13008 6 up up NN cord-005453-4057qib7 13008 7 of of IN cord-005453-4057qib7 13008 8 11 11 CD cord-005453-4057qib7 13008 9 months month NNS cord-005453-4057qib7 13008 10 ( ( -LRB- cord-005453-4057qib7 13008 11 3 3 CD cord-005453-4057qib7 13008 12 ) ) -RRB- cord-005453-4057qib7 13008 13 ( ( -LRB- cord-005453-4057qib7 13008 14 4 4 LS cord-005453-4057qib7 13008 15 ) ) -RRB- cord-005453-4057qib7 13008 16 ( ( -LRB- cord-005453-4057qib7 13008 17 5 5 LS cord-005453-4057qib7 13008 18 ) ) -RRB- cord-005453-4057qib7 13008 19 ( ( -LRB- cord-005453-4057qib7 13008 20 6 6 LS cord-005453-4057qib7 13008 21 ) ) -RRB- cord-005453-4057qib7 13008 22 ( ( -LRB- cord-005453-4057qib7 13008 23 7 7 LS cord-005453-4057qib7 13008 24 ) ) -RRB- cord-005453-4057qib7 13008 25 ( ( -LRB- cord-005453-4057qib7 13008 26 8) 8) NNP cord-005453-4057qib7 13008 27 ( ( -LRB- cord-005453-4057qib7 13008 28 9 9 CD cord-005453-4057qib7 13008 29 ) ) -RRB- cord-005453-4057qib7 13008 30 ( ( -LRB- cord-005453-4057qib7 13008 31 10 10 CD cord-005453-4057qib7 13008 32 ) ) -RRB- cord-005453-4057qib7 13008 33 ( ( -LRB- cord-005453-4057qib7 13008 34 11 11 CD cord-005453-4057qib7 13008 35 ) ) -RRB- cord-005453-4057qib7 13008 36 ( ( -LRB- cord-005453-4057qib7 13008 37 12 12 CD cord-005453-4057qib7 13008 38 ) ) -RRB- cord-005453-4057qib7 13008 39 ( ( -LRB- cord-005453-4057qib7 13008 40 13 13 CD cord-005453-4057qib7 13008 41 ) ) -RRB- cord-005453-4057qib7 13008 42 ( ( -LRB- cord-005453-4057qib7 13008 43 14 14 CD cord-005453-4057qib7 13008 44 ) ) -RRB- cord-005453-4057qib7 13008 45 ( ( -LRB- cord-005453-4057qib7 13008 46 15 15 CD cord-005453-4057qib7 13008 47 ) ) -RRB- cord-005453-4057qib7 13008 48 ( ( -LRB- cord-005453-4057qib7 13008 49 16 16 CD cord-005453-4057qib7 13008 50 ) ) -RRB- cord-005453-4057qib7 13008 51 ( ( -LRB- cord-005453-4057qib7 13008 52 17 17 CD cord-005453-4057qib7 13008 53 ) ) -RRB- cord-005453-4057qib7 13008 54 ( ( -LRB- cord-005453-4057qib7 13008 55 18 18 CD cord-005453-4057qib7 13008 56 ) ) -RRB- cord-005453-4057qib7 13008 57 ( ( -LRB- cord-005453-4057qib7 13008 58 19 19 CD cord-005453-4057qib7 13008 59 ) ) -RRB- cord-005453-4057qib7 13008 60 ( ( -LRB- cord-005453-4057qib7 13008 61 20 20 CD cord-005453-4057qib7 13008 62 ) ) -RRB- cord-005453-4057qib7 13008 63 the the DT cord-005453-4057qib7 13008 64 median median JJ cord-005453-4057qib7 13008 65 progression progression NN cord-005453-4057qib7 13008 66 - - HYPH cord-005453-4057qib7 13008 67 free free JJ cord-005453-4057qib7 13008 68 and and CC cord-005453-4057qib7 13008 69 overall overall JJ cord-005453-4057qib7 13008 70 survival survival NN cord-005453-4057qib7 13008 71 for for IN cord-005453-4057qib7 13008 72 the the DT cord-005453-4057qib7 13008 73 entire entire JJ cord-005453-4057qib7 13008 74 cohort cohort NN cord-005453-4057qib7 13008 75 were be VBD cord-005453-4057qib7 13008 76 7.5 7.5 CD cord-005453-4057qib7 13008 77 and and CC cord-005453-4057qib7 13008 78 9 9 CD cord-005453-4057qib7 13008 79 months month NNS cord-005453-4057qib7 13008 80 , , , cord-005453-4057qib7 13008 81 respectively respectively RB cord-005453-4057qib7 13008 82 . . . cord-005453-4057qib7 13009 1 Conclusions conclusion NNS cord-005453-4057qib7 13009 2 : : : cord-005453-4057qib7 13010 1 Autologous autologous JJ cord-005453-4057qib7 13010 2 anti anti JJ cord-005453-4057qib7 13010 3 - - JJ cord-005453-4057qib7 13010 4 CD19 cd19 JJ cord-005453-4057qib7 13010 5 CAR car NN cord-005453-4057qib7 13010 6 T t NN cord-005453-4057qib7 13010 7 - - HYPH cord-005453-4057qib7 13010 8 cell cell NN cord-005453-4057qib7 13010 9 therapy therapy NN cord-005453-4057qib7 13010 10 after after IN cord-005453-4057qib7 13010 11 debulking debulke VBG cord-005453-4057qib7 13010 12 treatment treatment NN cord-005453-4057qib7 13010 13 with with IN cord-005453-4057qib7 13010 14 antibodies antibody NNS cord-005453-4057qib7 13010 15 , , , cord-005453-4057qib7 13010 16 including include VBG cord-005453-4057qib7 13010 17 blinatumomab blinatumomab NNS cord-005453-4057qib7 13010 18 and/or and/or CC cord-005453-4057qib7 13010 19 IO IO NNP cord-005453-4057qib7 13010 20 , , , cord-005453-4057qib7 13010 21 is be VBZ cord-005453-4057qib7 13010 22 feasible feasible JJ cord-005453-4057qib7 13010 23 and and CC cord-005453-4057qib7 13010 24 results result NNS cord-005453-4057qib7 13010 25 in in IN cord-005453-4057qib7 13010 26 high high JJ cord-005453-4057qib7 13010 27 response response NN cord-005453-4057qib7 13010 28 rates rate NNS cord-005453-4057qib7 13010 29 in in IN cord-005453-4057qib7 13010 30 pts pts NN cord-005453-4057qib7 13010 31 with with IN cord-005453-4057qib7 13010 32 R r NN cord-005453-4057qib7 13010 33 / / SYM cord-005453-4057qib7 13010 34 R r NN cord-005453-4057qib7 13010 35 B b NN cord-005453-4057qib7 13010 36 - - : cord-005453-4057qib7 13010 37 ALL ALL NNP cord-005453-4057qib7 13010 38 . . . cord-005453-4057qib7 13011 1 Patients patient NNS cord-005453-4057qib7 13011 2 may may MD cord-005453-4057qib7 13011 3 respond respond VB cord-005453-4057qib7 13011 4 to to IN cord-005453-4057qib7 13011 5 anti anti JJ cord-005453-4057qib7 13011 6 - - JJ cord-005453-4057qib7 13011 7 CD19 cd19 JJ cord-005453-4057qib7 13011 8 CAR car NN cord-005453-4057qib7 13011 9 T t NN cord-005453-4057qib7 13011 10 - - HYPH cord-005453-4057qib7 13011 11 cell cell NN cord-005453-4057qib7 13011 12 therapy therapy NN cord-005453-4057qib7 13011 13 even even RB cord-005453-4057qib7 13011 14 after after IN cord-005453-4057qib7 13011 15 failure failure NN cord-005453-4057qib7 13011 16 to to IN cord-005453-4057qib7 13011 17 their -PRON- PRP$ cord-005453-4057qib7 13011 18 last last JJ cord-005453-4057qib7 13011 19 salvage salvage NN cord-005453-4057qib7 13011 20 therapy therapy NN cord-005453-4057qib7 13011 21 with with IN cord-005453-4057qib7 13011 22 blinatumomab blinatumomab NNP cord-005453-4057qib7 13011 23 , , , cord-005453-4057qib7 13011 24 which which WDT cord-005453-4057qib7 13011 25 demonstrates demonstrate VBZ cord-005453-4057qib7 13011 26 similar similar JJ cord-005453-4057qib7 13011 27 mechanism mechanism NN cord-005453-4057qib7 13011 28 of of IN cord-005453-4057qib7 13011 29 action action NN cord-005453-4057qib7 13011 30 . . . cord-005453-4057qib7 13012 1 Clinical clinical JJ cord-005453-4057qib7 13012 2 Background background NN cord-005453-4057qib7 13012 3 : : : cord-005453-4057qib7 13013 1 Genetically genetically RB cord-005453-4057qib7 13013 2 engineered engineer VBN cord-005453-4057qib7 13013 3 T t NN cord-005453-4057qib7 13013 4 cells cell NNS cord-005453-4057qib7 13013 5 expressing express VBG cord-005453-4057qib7 13013 6 a a DT cord-005453-4057qib7 13013 7 chimeric chimeric JJ cord-005453-4057qib7 13013 8 antigen antigen NN cord-005453-4057qib7 13013 9 receptor receptor NN cord-005453-4057qib7 13013 10 ( ( -LRB- cord-005453-4057qib7 13013 11 CAR CAR NNP cord-005453-4057qib7 13013 12 - - HYPH cord-005453-4057qib7 13013 13 T T NNP cord-005453-4057qib7 13013 14 ) ) -RRB- cord-005453-4057qib7 13013 15 targeting target VBG cord-005453-4057qib7 13013 16 specific specific JJ cord-005453-4057qib7 13013 17 antigens antigen NNS cord-005453-4057qib7 13013 18 present present JJ cord-005453-4057qib7 13013 19 on on IN cord-005453-4057qib7 13013 20 acute acute JJ cord-005453-4057qib7 13013 21 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13013 22 leukemia leukemia NN cord-005453-4057qib7 13013 23 ( ( -LRB- cord-005453-4057qib7 13013 24 ALL all DT cord-005453-4057qib7 13013 25 ) ) -RRB- cord-005453-4057qib7 13013 26 blasts blast NNS cord-005453-4057qib7 13013 27 have have VBP cord-005453-4057qib7 13013 28 generated generate VBN cord-005453-4057qib7 13013 29 promising promising JJ cord-005453-4057qib7 13013 30 results result NNS cord-005453-4057qib7 13013 31 in in IN cord-005453-4057qib7 13013 32 children child NNS cord-005453-4057qib7 13013 33 and and CC cord-005453-4057qib7 13013 34 adults adult NNS cord-005453-4057qib7 13013 35 with with IN cord-005453-4057qib7 13013 36 relapsed relapsed JJ cord-005453-4057qib7 13013 37 and and CC cord-005453-4057qib7 13013 38 refractory refractory JJ cord-005453-4057qib7 13013 39 disease disease NN cord-005453-4057qib7 13013 40 . . . cord-005453-4057qib7 13014 1 The the DT cord-005453-4057qib7 13014 2 below below JJ cord-005453-4057qib7 13014 3 report report NN cord-005453-4057qib7 13014 4 provides provide VBZ cord-005453-4057qib7 13014 5 an an DT cord-005453-4057qib7 13014 6 insight insight NN cord-005453-4057qib7 13014 7 of of IN cord-005453-4057qib7 13014 8 lineage lineage NN cord-005453-4057qib7 13014 9 switch switch NN cord-005453-4057qib7 13014 10 occuring occur VBG cord-005453-4057qib7 13014 11 as as IN cord-005453-4057qib7 13014 12 a a DT cord-005453-4057qib7 13014 13 result result NN cord-005453-4057qib7 13014 14 of of IN cord-005453-4057qib7 13014 15 intense intense JJ cord-005453-4057qib7 13014 16 immunological immunological JJ cord-005453-4057qib7 13014 17 selection selection NN cord-005453-4057qib7 13014 18 after after IN cord-005453-4057qib7 13014 19 CAR car NN cord-005453-4057qib7 13014 20 - - HYPH cord-005453-4057qib7 13014 21 T t NN cord-005453-4057qib7 13014 22 cell cell NN cord-005453-4057qib7 13014 23 therapy therapy NN cord-005453-4057qib7 13014 24 , , , cord-005453-4057qib7 13014 25 even even RB cord-005453-4057qib7 13014 26 with with IN cord-005453-4057qib7 13014 27 a a DT cord-005453-4057qib7 13014 28 tumor tumor NN cord-005453-4057qib7 13014 29 clone clone NN cord-005453-4057qib7 13014 30 that that WDT cord-005453-4057qib7 13014 31 has have VBZ cord-005453-4057qib7 13014 32 no no DT cord-005453-4057qib7 13014 33 potential potential NN cord-005453-4057qib7 13014 34 for for IN cord-005453-4057qib7 13014 35 this this DT cord-005453-4057qib7 13014 36 switch switch NN cord-005453-4057qib7 13014 37 . . . cord-005453-4057qib7 13015 1 Methods method NNS cord-005453-4057qib7 13015 2 : : : cord-005453-4057qib7 13016 1 An an DT cord-005453-4057qib7 13016 2 eight eight CD cord-005453-4057qib7 13016 3 year year NN cord-005453-4057qib7 13016 4 old old JJ cord-005453-4057qib7 13016 5 Caucasian caucasian JJ cord-005453-4057qib7 13016 6 male male NN cord-005453-4057qib7 13016 7 with with IN cord-005453-4057qib7 13016 8 precursor precursor NN cord-005453-4057qib7 13016 9 B b NN cord-005453-4057qib7 13016 10 ( ( -LRB- cord-005453-4057qib7 13016 11 pB pb NN cord-005453-4057qib7 13016 12 ) ) -RRB- cord-005453-4057qib7 13016 13 cell cell NN cord-005453-4057qib7 13016 14 lymphocytic lymphocytic JJ cord-005453-4057qib7 13016 15 leukemia leukemia NN cord-005453-4057qib7 13016 16 was be VBD cord-005453-4057qib7 13016 17 treated treat VBN cord-005453-4057qib7 13016 18 with with IN cord-005453-4057qib7 13016 19 CD CD NNP cord-005453-4057qib7 13016 20 19 19 CD cord-005453-4057qib7 13016 21 directed direct VBN cord-005453-4057qib7 13016 22 CAR CAR NNP cord-005453-4057qib7 13016 23 - - HYPH cord-005453-4057qib7 13016 24 T t NN cord-005453-4057qib7 13016 25 cell cell NN cord-005453-4057qib7 13016 26 therapy therapy NN cord-005453-4057qib7 13016 27 in in IN cord-005453-4057qib7 13016 28 third third JJ cord-005453-4057qib7 13016 29 remission remission NN cord-005453-4057qib7 13016 30 , , , cord-005453-4057qib7 13016 31 and and CC cord-005453-4057qib7 13016 32 after after IN cord-005453-4057qib7 13016 33 relapse relapse NN cord-005453-4057qib7 13016 34 after after IN cord-005453-4057qib7 13016 35 previous previous JJ cord-005453-4057qib7 13016 36 bone bone NN cord-005453-4057qib7 13016 37 marrow marrow NN cord-005453-4057qib7 13016 38 transplantation transplantation NN cord-005453-4057qib7 13016 39 ( ( -LRB- cord-005453-4057qib7 13016 40 BMT BMT NNP cord-005453-4057qib7 13016 41 ) ) -RRB- cord-005453-4057qib7 13016 42 . . . cord-005453-4057qib7 13017 1 He -PRON- PRP cord-005453-4057qib7 13017 2 was be VBD cord-005453-4057qib7 13017 3 diagnosed diagnose VBN cord-005453-4057qib7 13017 4 with with IN cord-005453-4057qib7 13017 5 t(12;21 t(12;21 ADD cord-005453-4057qib7 13017 6 ) ) -RRB- cord-005453-4057qib7 13018 1 pB pb NN cord-005453-4057qib7 13018 2 cell cell NN cord-005453-4057qib7 13018 3 ALL all DT cord-005453-4057qib7 13018 4 at at IN cord-005453-4057qib7 13018 5 2 2 CD cord-005453-4057qib7 13018 6 years year NNS cord-005453-4057qib7 13018 7 of of IN cord-005453-4057qib7 13018 8 age age NN cord-005453-4057qib7 13018 9 and and CC cord-005453-4057qib7 13018 10 treated treat VBN cord-005453-4057qib7 13018 11 with with IN cord-005453-4057qib7 13018 12 BFM BFM NNP cord-005453-4057qib7 13018 13 protocol protocol NN cord-005453-4057qib7 13018 14 . . . cord-005453-4057qib7 13019 1 He -PRON- PRP cord-005453-4057qib7 13019 2 relapsed relapse VBD cord-005453-4057qib7 13019 3 8 8 CD cord-005453-4057qib7 13019 4 months month NNS cord-005453-4057qib7 13019 5 after after IN cord-005453-4057qib7 13019 6 completion completion NN cord-005453-4057qib7 13019 7 of of IN cord-005453-4057qib7 13019 8 maintenance maintenance NN cord-005453-4057qib7 13019 9 therapy therapy NN cord-005453-4057qib7 13019 10 , , , cord-005453-4057qib7 13019 11 and and CC cord-005453-4057qib7 13019 12 had have VBD cord-005453-4057qib7 13019 13 a a DT cord-005453-4057qib7 13019 14 9/10 9/10 CD cord-005453-4057qib7 13019 15 MMUD MMUD NNP cord-005453-4057qib7 13019 16 bone bone NN cord-005453-4057qib7 13019 17 marrow marrow NN cord-005453-4057qib7 13019 18 transplant transplant NN cord-005453-4057qib7 13019 19 after after IN cord-005453-4057qib7 13019 20 etoposide etoposide NN cord-005453-4057qib7 13019 21 , , , cord-005453-4057qib7 13019 22 TBI TBI NNP cord-005453-4057qib7 13019 23 and and CC cord-005453-4057qib7 13019 24 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 13019 25 conditioning conditioning NN cord-005453-4057qib7 13019 26 therapy therapy NN cord-005453-4057qib7 13019 27 . . . cord-005453-4057qib7 13020 1 He -PRON- PRP cord-005453-4057qib7 13020 2 had have VBD cord-005453-4057qib7 13020 3 cutaneous cutaneous JJ cord-005453-4057qib7 13020 4 acute acute JJ cord-005453-4057qib7 13020 5 and and CC cord-005453-4057qib7 13020 6 chronic chronic JJ cord-005453-4057qib7 13020 7 GVHD GVHD NNP cord-005453-4057qib7 13020 8 but but CC cord-005453-4057qib7 13021 1 8 8 CD cord-005453-4057qib7 13021 2 months month NNS cord-005453-4057qib7 13021 3 post post NN cord-005453-4057qib7 13021 4 - - NN cord-005453-4057qib7 13021 5 transplant transplant NN cord-005453-4057qib7 13021 6 , , , cord-005453-4057qib7 13021 7 he -PRON- PRP cord-005453-4057qib7 13021 8 relapsed relapse VBD cord-005453-4057qib7 13021 9 again again RB cord-005453-4057qib7 13021 10 with with IN cord-005453-4057qib7 13021 11 pB pb NN cord-005453-4057qib7 13021 12 cell cell NN cord-005453-4057qib7 13021 13 ALL all DT cord-005453-4057qib7 13021 14 , , , cord-005453-4057qib7 13021 15 with with IN cord-005453-4057qib7 13021 16 the the DT cord-005453-4057qib7 13021 17 same same JJ cord-005453-4057qib7 13021 18 cytogenetic cytogenetic NN cord-005453-4057qib7 13021 19 and and CC cord-005453-4057qib7 13021 20 immunophenotypic immunophenotypic JJ cord-005453-4057qib7 13021 21 disease disease NN cord-005453-4057qib7 13021 22 characteristics characteristic NNS cord-005453-4057qib7 13021 23 .. .. . cord-005453-4057qib7 13022 1 He -PRON- PRP cord-005453-4057qib7 13022 2 was be VBD cord-005453-4057qib7 13022 3 treated treat VBN cord-005453-4057qib7 13022 4 with with IN cord-005453-4057qib7 13022 5 lymphodepleting lymphodeplete VBG cord-005453-4057qib7 13022 6 chemotherapy chemotherapy NN cord-005453-4057qib7 13022 7 with with IN cord-005453-4057qib7 13022 8 fludarabine fludarabine NN cord-005453-4057qib7 13022 9 , , , cord-005453-4057qib7 13022 10 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 13022 11 and and CC cord-005453-4057qib7 13022 12 alemtuzumab alemtuzumab NNS cord-005453-4057qib7 13022 13 followed follow VBN cord-005453-4057qib7 13022 14 by by IN cord-005453-4057qib7 13022 15 infusion infusion NN cord-005453-4057qib7 13022 16 of of IN cord-005453-4057qib7 13022 17 CD19 CD19 NNP cord-005453-4057qib7 13022 18 directed direct VBD cord-005453-4057qib7 13022 19 CAR CAR NNP cord-005453-4057qib7 13022 20 T T NNP cord-005453-4057qib7 13022 21 cells cell NNS cord-005453-4057qib7 13022 22 . . . cord-005453-4057qib7 13023 1 He -PRON- PRP cord-005453-4057qib7 13023 2 developed develop VBD cord-005453-4057qib7 13023 3 cytokine cytokine NN cord-005453-4057qib7 13023 4 release release NN cord-005453-4057qib7 13023 5 syndrome syndrome NN cord-005453-4057qib7 13023 6 of of IN cord-005453-4057qib7 13023 7 grade grade NN cord-005453-4057qib7 13023 8 1 1 CD cord-005453-4057qib7 13023 9 severity severity NN cord-005453-4057qib7 13023 10 manifested manifest VBD cord-005453-4057qib7 13023 11 as as IN cord-005453-4057qib7 13023 12 persistent persistent JJ cord-005453-4057qib7 13023 13 fever fever NN cord-005453-4057qib7 13023 14 , , , cord-005453-4057qib7 13023 15 associated associate VBN cord-005453-4057qib7 13023 16 with with IN cord-005453-4057qib7 13023 17 CAR car NN cord-005453-4057qib7 13023 18 T T NNP cord-005453-4057qib7 13023 19 cell cell NN cord-005453-4057qib7 13023 20 expansion expansion NN cord-005453-4057qib7 13023 21 in in IN cord-005453-4057qib7 13023 22 the the DT cord-005453-4057qib7 13023 23 blood blood NN cord-005453-4057qib7 13023 24 . . . cord-005453-4057qib7 13024 1 After after IN cord-005453-4057qib7 13024 2 CAR car NN cord-005453-4057qib7 13024 3 - - HYPH cord-005453-4057qib7 13024 4 T t NN cord-005453-4057qib7 13024 5 infusion infusion NN cord-005453-4057qib7 13024 6 , , , cord-005453-4057qib7 13024 7 there there EX cord-005453-4057qib7 13024 8 was be VBD cord-005453-4057qib7 13024 9 no no DT cord-005453-4057qib7 13024 10 detectable detectable JJ cord-005453-4057qib7 13024 11 B b NN cord-005453-4057qib7 13024 12 cell cell NN cord-005453-4057qib7 13025 1 ALL all DT cord-005453-4057qib7 13025 2 clone clone NN cord-005453-4057qib7 13025 3 in in IN cord-005453-4057qib7 13025 4 the the DT cord-005453-4057qib7 13025 5 marrow marrow NN cord-005453-4057qib7 13025 6 by by IN cord-005453-4057qib7 13025 7 PCR PCR NNP cord-005453-4057qib7 13025 8 and and CC cord-005453-4057qib7 13025 9 the the DT cord-005453-4057qib7 13025 10 cytogenetics cytogenetic NNS cord-005453-4057qib7 13025 11 were be VBD cord-005453-4057qib7 13025 12 negative negative JJ cord-005453-4057qib7 13025 13 for for IN cord-005453-4057qib7 13025 14 t(12:21 t(12:21 ADD cord-005453-4057qib7 13025 15 ) ) -RRB- cord-005453-4057qib7 13025 16 translocation translocation NN cord-005453-4057qib7 13025 17 . . . cord-005453-4057qib7 13026 1 8 8 CD cord-005453-4057qib7 13026 2 months month NNS cord-005453-4057qib7 13026 3 after after IN cord-005453-4057qib7 13026 4 the the DT cord-005453-4057qib7 13026 5 CAR car NN cord-005453-4057qib7 13026 6 T t NN cord-005453-4057qib7 13026 7 cell cell NN cord-005453-4057qib7 13026 8 therapy therapy NN cord-005453-4057qib7 13026 9 , , , cord-005453-4057qib7 13026 10 he -PRON- PRP cord-005453-4057qib7 13026 11 was be VBD cord-005453-4057qib7 13026 12 found find VBN cord-005453-4057qib7 13026 13 to to TO cord-005453-4057qib7 13026 14 have have VB cord-005453-4057qib7 13026 15 a a DT cord-005453-4057qib7 13026 16 MRD MRD NNP cord-005453-4057qib7 13026 17 positive positive JJ cord-005453-4057qib7 13026 18 disease disease NN cord-005453-4057qib7 13026 19 which which WDT cord-005453-4057qib7 13026 20 was be VBD cord-005453-4057qib7 13026 21 monitored monitor VBN cord-005453-4057qib7 13026 22 closely closely RB cord-005453-4057qib7 13026 23 . . . cord-005453-4057qib7 13027 1 Results result NNS cord-005453-4057qib7 13027 2 : : : cord-005453-4057qib7 13028 1 We -PRON- PRP cord-005453-4057qib7 13028 2 document document VBP cord-005453-4057qib7 13028 3 clonal clonal JJ cord-005453-4057qib7 13028 4 evolution evolution NN cord-005453-4057qib7 13028 5 from from IN cord-005453-4057qib7 13028 6 CD19 CD19 NNP cord-005453-4057qib7 13028 7 negative negative JJ cord-005453-4057qib7 13028 8 , , , cord-005453-4057qib7 13028 9 MRD MRD NNP cord-005453-4057qib7 13028 10 positive positive JJ cord-005453-4057qib7 13028 11 disease disease NN cord-005453-4057qib7 13028 12 to to IN cord-005453-4057qib7 13028 13 AML AML NNP cord-005453-4057qib7 13028 14 , , , cord-005453-4057qib7 13028 15 with with IN cord-005453-4057qib7 13028 16 the the DT cord-005453-4057qib7 13028 17 same same JJ cord-005453-4057qib7 13028 18 Ig Ig NNP cord-005453-4057qib7 13028 19 rearrangement rearrangement NN cord-005453-4057qib7 13028 20 ( ( -LRB- cord-005453-4057qib7 13028 21 the the DT cord-005453-4057qib7 13028 22 same same JJ cord-005453-4057qib7 13028 23 clonal clonal JJ cord-005453-4057qib7 13028 24 disease disease NN cord-005453-4057qib7 13028 25 ) ) -RRB- cord-005453-4057qib7 13028 26 but but CC cord-005453-4057qib7 13028 27 with with IN cord-005453-4057qib7 13028 28 complete complete JJ cord-005453-4057qib7 13028 29 myeloid myeloid JJ cord-005453-4057qib7 13028 30 phenotype phenotype NN cord-005453-4057qib7 13028 31 MPO MPO NNP cord-005453-4057qib7 13028 32 , , , cord-005453-4057qib7 13028 33 CD33 CD33 NNP cord-005453-4057qib7 13028 34 , , , cord-005453-4057qib7 13028 35 CD13 CD13 NNP cord-005453-4057qib7 13028 36 positive positive JJ cord-005453-4057qib7 13028 37 disease disease NN cord-005453-4057qib7 13028 38 . . . cord-005453-4057qib7 13029 1 There there EX cord-005453-4057qib7 13029 2 was be VBD cord-005453-4057qib7 13029 3 cytogenetic cytogenetic JJ cord-005453-4057qib7 13029 4 evolution evolution NN cord-005453-4057qib7 13029 5 of of IN cord-005453-4057qib7 13029 6 the the DT cord-005453-4057qib7 13029 7 underlying underlie VBG cord-005453-4057qib7 13029 8 clone clone NN cord-005453-4057qib7 13029 9 but but CC cord-005453-4057qib7 13029 10 the the DT cord-005453-4057qib7 13029 11 original original JJ cord-005453-4057qib7 13029 12 t(12;21 t(12;21 CD cord-005453-4057qib7 13029 13 ) ) -RRB- cord-005453-4057qib7 13029 14 was be VBD cord-005453-4057qib7 13029 15 retained retain VBN cord-005453-4057qib7 13029 16 within within IN cord-005453-4057qib7 13029 17 the the DT cord-005453-4057qib7 13029 18 evolved evolved JJ cord-005453-4057qib7 13029 19 karyotype karyotype NN cord-005453-4057qib7 13029 20 . . . cord-005453-4057qib7 13030 1 Sadly sadly RB cord-005453-4057qib7 13030 2 , , , cord-005453-4057qib7 13030 3 our -PRON- PRP$ cord-005453-4057qib7 13030 4 patient patient NN cord-005453-4057qib7 13030 5 developed develop VBD cord-005453-4057qib7 13030 6 fludarabineneurotoxcity fludarabineneurotoxcity NN cord-005453-4057qib7 13030 7 during during IN cord-005453-4057qib7 13030 8 an an DT cord-005453-4057qib7 13030 9 attempt attempt NN cord-005453-4057qib7 13030 10 to to TO cord-005453-4057qib7 13030 11 induce induce VB cord-005453-4057qib7 13030 12 AML AML NNP cord-005453-4057qib7 13030 13 remission remission NN cord-005453-4057qib7 13030 14 , , , cord-005453-4057qib7 13030 15 and and CC cord-005453-4057qib7 13030 16 further further JJ cord-005453-4057qib7 13030 17 curative curative JJ cord-005453-4057qib7 13030 18 - - HYPH cord-005453-4057qib7 13030 19 intent intent NN cord-005453-4057qib7 13030 20 chemotherapy chemotherapy NN cord-005453-4057qib7 13030 21 was be VBD cord-005453-4057qib7 13030 22 not not RB cord-005453-4057qib7 13030 23 possible possible JJ cord-005453-4057qib7 13030 24 . . . cord-005453-4057qib7 13031 1 Conclusions conclusion NNS cord-005453-4057qib7 13031 2 : : : cord-005453-4057qib7 13032 1 There there EX cord-005453-4057qib7 13032 2 are be VBP cord-005453-4057qib7 13032 3 two two CD cord-005453-4057qib7 13032 4 case case NN cord-005453-4057qib7 13032 5 reports report NNS cord-005453-4057qib7 13032 6 of of IN cord-005453-4057qib7 13032 7 MLL MLL NNP cord-005453-4057qib7 13032 8 rearranged rearrange VBD cord-005453-4057qib7 13032 9 B B NNP cord-005453-4057qib7 13032 10 - - : cord-005453-4057qib7 13032 11 ALL all DT cord-005453-4057qib7 13032 12 acquiring acquire VBG cord-005453-4057qib7 13032 13 a a DT cord-005453-4057qib7 13032 14 clonally clonally RB cord-005453-4057qib7 13032 15 related relate VBN cord-005453-4057qib7 13032 16 myeloid myeloid NN cord-005453-4057qib7 13032 17 phenotype phenotype NN cord-005453-4057qib7 13032 18 associated associate VBN cord-005453-4057qib7 13032 19 with with IN cord-005453-4057qib7 13032 20 CD19-negative cd19-negative CD cord-005453-4057qib7 13032 21 escape escape NN cord-005453-4057qib7 13032 22 after after IN cord-005453-4057qib7 13032 23 CD19 CD19 NNP cord-005453-4057qib7 13032 24 directed direct VBD cord-005453-4057qib7 13032 25 CAR CAR NNP cord-005453-4057qib7 13032 26 T t NN cord-005453-4057qib7 13032 27 cell cell NN cord-005453-4057qib7 13032 28 therapy therapy NN cord-005453-4057qib7 13032 29 , , , cord-005453-4057qib7 13032 30 so so RB cord-005453-4057qib7 13032 31 far far RB cord-005453-4057qib7 13032 32 . . . cord-005453-4057qib7 13033 1 But but CC cord-005453-4057qib7 13033 2 , , , cord-005453-4057qib7 13033 3 this this DT cord-005453-4057qib7 13033 4 is be VBZ cord-005453-4057qib7 13033 5 the the DT cord-005453-4057qib7 13033 6 first first JJ cord-005453-4057qib7 13033 7 Post Post NNP cord-005453-4057qib7 13033 8 CAR CAR NNP cord-005453-4057qib7 13033 9 - - HYPH cord-005453-4057qib7 13033 10 T t NN cord-005453-4057qib7 13033 11 cell cell NN cord-005453-4057qib7 13033 12 therapy therapy NN cord-005453-4057qib7 13033 13 transformation transformation NN cord-005453-4057qib7 13033 14 of of IN cord-005453-4057qib7 13033 15 ALL all DT cord-005453-4057qib7 13033 16 to to IN cord-005453-4057qib7 13033 17 AML AML NNP cord-005453-4057qib7 13033 18 with with IN cord-005453-4057qib7 13033 19 ETV6-RUNX1 ETV6-RUNX1 NNP cord-005453-4057qib7 13033 20 mutation mutation NN cord-005453-4057qib7 13033 21 , , , cord-005453-4057qib7 13033 22 which which WDT cord-005453-4057qib7 13033 23 is be VBZ cord-005453-4057qib7 13033 24 not not RB cord-005453-4057qib7 13033 25 recognised recognise VBN cord-005453-4057qib7 13033 26 to to TO cord-005453-4057qib7 13033 27 have have VB cord-005453-4057qib7 13033 28 such such JJ cord-005453-4057qib7 13033 29 lineage lineage NN cord-005453-4057qib7 13033 30 - - HYPH cord-005453-4057qib7 13033 31 switch switch NN cord-005453-4057qib7 13033 32 potential potential NN cord-005453-4057qib7 13033 33 . . . cord-005453-4057qib7 13034 1 Unlike unlike IN cord-005453-4057qib7 13034 2 MLL MLL NNP cord-005453-4057qib7 13034 3 , , , cord-005453-4057qib7 13034 4 ETV6-RUNX1 etv6-runx1 NN cord-005453-4057qib7 13034 5 translocation translocation NN cord-005453-4057qib7 13034 6 in in IN cord-005453-4057qib7 13034 7 the the DT cord-005453-4057qib7 13034 8 pathogenesis pathogenesis NN cord-005453-4057qib7 13034 9 of of IN cord-005453-4057qib7 13034 10 acute acute JJ cord-005453-4057qib7 13034 11 myeloid myeloid JJ cord-005453-4057qib7 13034 12 leukemia leukemia NN cord-005453-4057qib7 13034 13 is be VBZ cord-005453-4057qib7 13034 14 not not RB cord-005453-4057qib7 13034 15 been be VBN cord-005453-4057qib7 13034 16 reported report VBN cord-005453-4057qib7 13034 17 in in IN cord-005453-4057qib7 13034 18 the the DT cord-005453-4057qib7 13034 19 literature literature NN cord-005453-4057qib7 13034 20 . . . cord-005453-4057qib7 13035 1 The the DT cord-005453-4057qib7 13035 2 theory theory NN cord-005453-4057qib7 13035 3 behind behind IN cord-005453-4057qib7 13035 4 such such JJ cord-005453-4057qib7 13035 5 transformation transformation NN cord-005453-4057qib7 13035 6 is be VBZ cord-005453-4057qib7 13035 7 an an DT cord-005453-4057qib7 13035 8 intense intense JJ cord-005453-4057qib7 13035 9 immunological immunological JJ cord-005453-4057qib7 13035 10 selection selection NN cord-005453-4057qib7 13035 11 of of IN cord-005453-4057qib7 13035 12 the the DT cord-005453-4057qib7 13035 13 tumor tumor NN cord-005453-4057qib7 13035 14 , , , cord-005453-4057qib7 13035 15 driving drive VBG cord-005453-4057qib7 13035 16 it -PRON- PRP cord-005453-4057qib7 13035 17 to to IN cord-005453-4057qib7 13035 18 myeloid myeloid JJ cord-005453-4057qib7 13035 19 differentiation differentiation NN cord-005453-4057qib7 13035 20 with with IN cord-005453-4057qib7 13035 21 additional additional JJ cord-005453-4057qib7 13035 22 clonal clonal JJ cord-005453-4057qib7 13035 23 cytogenetic cytogenetic JJ cord-005453-4057qib7 13035 24 events event NNS cord-005453-4057qib7 13035 25 . . . cord-005453-4057qib7 13036 1 Disclosure disclosure NN cord-005453-4057qib7 13036 2 : : : cord-005453-4057qib7 13036 3 Nothing nothing NN cord-005453-4057qib7 13036 4 to to TO cord-005453-4057qib7 13036 5 declare declare VB cord-005453-4057qib7 13036 6 P586 P586 NNP cord-005453-4057qib7 13036 7 IVAC IVAC NNP cord-005453-4057qib7 13036 8 - - HYPH cord-005453-4057qib7 13036 9 all-1 all-1 NNP cord-005453-4057qib7 13036 10 : : : cord-005453-4057qib7 13036 11 interim interim JJ cord-005453-4057qib7 13036 12 analysis analysis NN cord-005453-4057qib7 13036 13 of of IN cord-005453-4057qib7 13036 14 a a DT cord-005453-4057qib7 13036 15 phase phase NN cord-005453-4057qib7 13036 16 I -PRON- PRP cord-005453-4057qib7 13036 17 / / SYM cord-005453-4057qib7 13036 18 II II NNP cord-005453-4057qib7 13036 19 clinical clinical JJ cord-005453-4057qib7 13036 20 study study NN cord-005453-4057qib7 13036 21 on on IN cord-005453-4057qib7 13036 22 personalized personalized JJ cord-005453-4057qib7 13036 23 peptide peptide NN cord-005453-4057qib7 13036 24 vaccination vaccination NN cord-005453-4057qib7 13036 25 based base VBN cord-005453-4057qib7 13036 26 on on IN cord-005453-4057qib7 13036 27 patient patient JJ cord-005453-4057qib7 13036 28 - - HYPH cord-005453-4057qib7 13036 29 individual individual JJ cord-005453-4057qib7 13036 30 tumor tumor NN cord-005453-4057qib7 13036 31 - - HYPH cord-005453-4057qib7 13036 32 specific specific JJ cord-005453-4057qib7 13036 33 variants variant NNS cord-005453-4057qib7 13036 34 in in IN cord-005453-4057qib7 13036 35 relapsed relapse VBN cord-005453-4057qib7 13036 36 pediatric pediatric JJ cord-005453-4057qib7 13036 37 acute acute JJ cord-005453-4057qib7 13036 38 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13036 39 leukemia leukemia NN cord-005453-4057qib7 13036 40 Armin Armin NNP cord-005453-4057qib7 13036 41 Rabsteyn Rabsteyn NNP cord-005453-4057qib7 13036 42 1,2 1,2 CD cord-005453-4057qib7 13036 43 , , , cord-005453-4057qib7 13036 44 Christopher Christopher NNP cord-005453-4057qib7 13036 45 Mohr Mohr NNP cord-005453-4057qib7 13036 46 3 3 CD cord-005453-4057qib7 13036 47 , , , cord-005453-4057qib7 13036 48 Olaf Olaf NNP cord-005453-4057qib7 13036 49 Witt Witt NNP cord-005453-4057qib7 13036 50 2,4 2,4 CD cord-005453-4057qib7 13036 51 , , , cord-005453-4057qib7 13036 52 Roland Roland NNP cord-005453-4057qib7 13036 53 Meisel Meisel NNP cord-005453-4057qib7 13036 54 2,5 2,5 NNP cord-005453-4057qib7 13036 55 , , , cord-005453-4057qib7 13036 56 Cristiane Cristiane NNP cord-005453-4057qib7 13036 57 Chen Chen NNP cord-005453-4057qib7 13036 58 - - HYPH cord-005453-4057qib7 13036 59 Santel Santel NNP cord-005453-4057qib7 13036 60 6 6 CD cord-005453-4057qib7 13036 61 , , , cord-005453-4057qib7 13036 62 Tobias Tobias NNP cord-005453-4057qib7 13036 63 Feuchtinger Feuchtinger NNP cord-005453-4057qib7 13036 64 2,7 2,7 CD cord-005453-4057qib7 13036 65 , , , cord-005453-4057qib7 13036 66 Christopher Christopher NNP cord-005453-4057qib7 13036 67 Schroeder Schroeder NNP cord-005453-4057qib7 13036 68 8 8 CD cord-005453-4057qib7 13036 69 , , , cord-005453-4057qib7 13036 70 Jakob Jakob NNP cord-005453-4057qib7 13036 71 Matthes Matthes NNP cord-005453-4057qib7 13036 72 8 8 CD cord-005453-4057qib7 13036 73 , , , cord-005453-4057qib7 13036 74 Background background NN cord-005453-4057qib7 13036 75 : : : cord-005453-4057qib7 13037 1 Acute acute JJ cord-005453-4057qib7 13037 2 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13037 3 leukemia leukemia NN cord-005453-4057qib7 13037 4 ( ( -LRB- cord-005453-4057qib7 13037 5 ALL all DT cord-005453-4057qib7 13037 6 ) ) -RRB- cord-005453-4057qib7 13037 7 is be VBZ cord-005453-4057qib7 13037 8 the the DT cord-005453-4057qib7 13037 9 most most RBS cord-005453-4057qib7 13037 10 common common JJ cord-005453-4057qib7 13037 11 pediatric pediatric JJ cord-005453-4057qib7 13037 12 malignancy malignancy NN cord-005453-4057qib7 13037 13 . . . cord-005453-4057qib7 13038 1 Standard standard JJ cord-005453-4057qib7 13038 2 chemotherapy chemotherapy NN cord-005453-4057qib7 13038 3 is be VBZ cord-005453-4057qib7 13038 4 a a DT cord-005453-4057qib7 13038 5 successful successful JJ cord-005453-4057qib7 13038 6 treatment treatment NN cord-005453-4057qib7 13038 7 in in IN cord-005453-4057qib7 13038 8 80 80 CD cord-005453-4057qib7 13038 9 % % NN cord-005453-4057qib7 13038 10 of of IN cord-005453-4057qib7 13038 11 patients patient NNS cord-005453-4057qib7 13038 12 , , , cord-005453-4057qib7 13038 13 only only RB cord-005453-4057qib7 13038 14 about about IN cord-005453-4057qib7 13038 15 20 20 CD cord-005453-4057qib7 13038 16 % % NN cord-005453-4057qib7 13038 17 develop develop VBP cord-005453-4057qib7 13038 18 a a DT cord-005453-4057qib7 13038 19 relapse relapse NN cord-005453-4057qib7 13038 20 , , , cord-005453-4057qib7 13038 21 however however RB cord-005453-4057qib7 13038 22 these these DT cord-005453-4057qib7 13038 23 patients patient NNS cord-005453-4057qib7 13038 24 have have VBP cord-005453-4057qib7 13038 25 a a DT cord-005453-4057qib7 13038 26 dismal dismal JJ cord-005453-4057qib7 13038 27 prognosis prognosis NN cord-005453-4057qib7 13038 28 . . . cord-005453-4057qib7 13039 1 Prevention prevention NN cord-005453-4057qib7 13039 2 of of IN cord-005453-4057qib7 13039 3 relapse relapse NN cord-005453-4057qib7 13039 4 after after IN cord-005453-4057qib7 13039 5 firstline firstline JJ cord-005453-4057qib7 13039 6 chemotherapy chemotherapy NN cord-005453-4057qib7 13039 7 or or CC cord-005453-4057qib7 13039 8 stem stem NN cord-005453-4057qib7 13039 9 cell cell NN cord-005453-4057qib7 13039 10 transplantation transplantation NN cord-005453-4057qib7 13039 11 ( ( -LRB- cord-005453-4057qib7 13039 12 SCT SCT NNP cord-005453-4057qib7 13039 13 ) ) -RRB- cord-005453-4057qib7 13039 14 is be VBZ cord-005453-4057qib7 13039 15 therefore therefore RB cord-005453-4057qib7 13039 16 an an DT cord-005453-4057qib7 13039 17 urgent urgent JJ cord-005453-4057qib7 13039 18 clinical clinical JJ cord-005453-4057qib7 13039 19 need need NN cord-005453-4057qib7 13039 20 . . . cord-005453-4057qib7 13040 1 We -PRON- PRP cord-005453-4057qib7 13040 2 established establish VBD cord-005453-4057qib7 13040 3 a a DT cord-005453-4057qib7 13040 4 platform platform NN cord-005453-4057qib7 13040 5 for for IN cord-005453-4057qib7 13040 6 the the DT cord-005453-4057qib7 13040 7 design design NN cord-005453-4057qib7 13040 8 of of IN cord-005453-4057qib7 13040 9 patient patient JJ cord-005453-4057qib7 13040 10 - - HYPH cord-005453-4057qib7 13040 11 individual individual JJ cord-005453-4057qib7 13040 12 peptide peptide NN cord-005453-4057qib7 13040 13 vaccination vaccination NN cord-005453-4057qib7 13040 14 cocktails cocktail NNS cord-005453-4057qib7 13040 15 by by IN cord-005453-4057qib7 13040 16 combination combination NN cord-005453-4057qib7 13040 17 of of IN cord-005453-4057qib7 13040 18 whole whole JJ cord-005453-4057qib7 13040 19 exome exome NN cord-005453-4057qib7 13040 20 sequencing sequencing NN cord-005453-4057qib7 13040 21 of of IN cord-005453-4057qib7 13040 22 tumor tumor NN cord-005453-4057qib7 13040 23 and and CC cord-005453-4057qib7 13040 24 normal normal JJ cord-005453-4057qib7 13040 25 tissue tissue NN cord-005453-4057qib7 13040 26 with with IN cord-005453-4057qib7 13040 27 in in IN cord-005453-4057qib7 13040 28 silico silico NN cord-005453-4057qib7 13040 29 epitope epitope NN cord-005453-4057qib7 13040 30 prediction prediction NN cord-005453-4057qib7 13040 31 algorithms algorithm NNS cord-005453-4057qib7 13040 32 for for IN cord-005453-4057qib7 13040 33 individual individual JJ cord-005453-4057qib7 13040 34 patient patient NN cord-005453-4057qib7 13040 35 HLA HLA NNP cord-005453-4057qib7 13040 36 types type NNS cord-005453-4057qib7 13040 37 . . . cord-005453-4057qib7 13041 1 We -PRON- PRP cord-005453-4057qib7 13041 2 started start VBD cord-005453-4057qib7 13041 3 clinical clinical JJ cord-005453-4057qib7 13041 4 translation translation NN cord-005453-4057qib7 13041 5 of of IN cord-005453-4057qib7 13041 6 this this DT cord-005453-4057qib7 13041 7 approach approach NN cord-005453-4057qib7 13041 8 by by IN cord-005453-4057qib7 13041 9 starting start VBG cord-005453-4057qib7 13041 10 a a DT cord-005453-4057qib7 13041 11 phase phase NN cord-005453-4057qib7 13041 12 I -PRON- PRP cord-005453-4057qib7 13041 13 / / SYM cord-005453-4057qib7 13041 14 II II NNP cord-005453-4057qib7 13041 15 clinical clinical JJ cord-005453-4057qib7 13041 16 trial trial NN cord-005453-4057qib7 13041 17 in in IN cord-005453-4057qib7 13041 18 2016 2016 CD cord-005453-4057qib7 13041 19 ( ( -LRB- cord-005453-4057qib7 13041 20 NCT03559413 NCT03559413 NNP cord-005453-4057qib7 13041 21 ) ) -RRB- cord-005453-4057qib7 13041 22 . . . cord-005453-4057qib7 13042 1 Besides besides IN cord-005453-4057qib7 13042 2 feasibility feasibility NN cord-005453-4057qib7 13042 3 and and CC cord-005453-4057qib7 13042 4 toxicity toxicity NN cord-005453-4057qib7 13042 5 assessments assessment NNS cord-005453-4057qib7 13042 6 , , , cord-005453-4057qib7 13042 7 we -PRON- PRP cord-005453-4057qib7 13042 8 aim aim VBP cord-005453-4057qib7 13042 9 to to TO cord-005453-4057qib7 13042 10 assess assess VB cord-005453-4057qib7 13042 11 the the DT cord-005453-4057qib7 13042 12 capability capability NN cord-005453-4057qib7 13042 13 of of IN cord-005453-4057qib7 13042 14 the the DT cord-005453-4057qib7 13042 15 peptide peptide NN cord-005453-4057qib7 13042 16 vaccination vaccination NN cord-005453-4057qib7 13042 17 to to TO cord-005453-4057qib7 13042 18 induce induce VB cord-005453-4057qib7 13042 19 neoantigen neoantigen NN cord-005453-4057qib7 13042 20 - - HYPH cord-005453-4057qib7 13042 21 specific specific JJ cord-005453-4057qib7 13042 22 T T NNP cord-005453-4057qib7 13042 23 cell cell NN cord-005453-4057qib7 13042 24 responses response NNS cord-005453-4057qib7 13042 25 in in IN cord-005453-4057qib7 13042 26 high high JJ cord-005453-4057qib7 13042 27 - - HYPH cord-005453-4057qib7 13042 28 risk risk NN cord-005453-4057qib7 13042 29 ALL all DT cord-005453-4057qib7 13042 30 patients patient NNS cord-005453-4057qib7 13042 31 to to TO cord-005453-4057qib7 13042 32 target target VB cord-005453-4057qib7 13042 33 residual residual JJ cord-005453-4057qib7 13042 34 tumor tumor NN cord-005453-4057qib7 13042 35 cells cell NNS cord-005453-4057qib7 13042 36 and and CC cord-005453-4057qib7 13042 37 prevent prevent VB cord-005453-4057qib7 13042 38 leukemic leukemic JJ cord-005453-4057qib7 13042 39 relapses relapse NNS cord-005453-4057qib7 13042 40 . . . cord-005453-4057qib7 13043 1 Methods method NNS cord-005453-4057qib7 13043 2 : : : cord-005453-4057qib7 13043 3 Key key JJ cord-005453-4057qib7 13043 4 inclusion inclusion NN cord-005453-4057qib7 13043 5 criteria criterion NNS cord-005453-4057qib7 13043 6 are be VBP cord-005453-4057qib7 13043 7 : : : cord-005453-4057qib7 13043 8 pediatric pediatric JJ cord-005453-4057qib7 13043 9 patients patient NNS cord-005453-4057qib7 13043 10 with with IN cord-005453-4057qib7 13043 11 ALL all DT cord-005453-4057qib7 13043 12 who who WP cord-005453-4057qib7 13043 13 suffered suffer VBD cord-005453-4057qib7 13043 14 from from IN cord-005453-4057qib7 13043 15 second second JJ cord-005453-4057qib7 13043 16 relapse relapse NN cord-005453-4057qib7 13043 17 after after IN cord-005453-4057qib7 13043 18 standard standard JJ cord-005453-4057qib7 13043 19 therapy therapy NN cord-005453-4057qib7 13043 20 or or CC cord-005453-4057qib7 13043 21 first first JJ cord-005453-4057qib7 13043 22 relapse relapse NN cord-005453-4057qib7 13043 23 after after IN cord-005453-4057qib7 13043 24 SCT SCT NNP cord-005453-4057qib7 13043 25 . . . cord-005453-4057qib7 13044 1 Hematological Hematological NNP cord-005453-4057qib7 13044 2 remission remission NN cord-005453-4057qib7 13044 3 has have VBZ cord-005453-4057qib7 13044 4 to to TO cord-005453-4057qib7 13044 5 be be VB cord-005453-4057qib7 13044 6 reached reach VBN cord-005453-4057qib7 13044 7 prior prior RB cord-005453-4057qib7 13044 8 to to IN cord-005453-4057qib7 13044 9 vaccination vaccination NN cord-005453-4057qib7 13044 10 . . . cord-005453-4057qib7 13045 1 Nonsynonymous nonsynonymous JJ cord-005453-4057qib7 13045 2 mutations mutation NNS cord-005453-4057qib7 13045 3 are be VBP cord-005453-4057qib7 13045 4 identified identify VBN cord-005453-4057qib7 13045 5 by by IN cord-005453-4057qib7 13045 6 whole whole JJ cord-005453-4057qib7 13045 7 exome exome NN cord-005453-4057qib7 13045 8 and and CC cord-005453-4057qib7 13045 9 transcriptome transcriptome NN cord-005453-4057qib7 13045 10 sequencing sequencing NN cord-005453-4057qib7 13045 11 of of IN cord-005453-4057qib7 13045 12 patient patient JJ cord-005453-4057qib7 13045 13 leukemic leukemic JJ cord-005453-4057qib7 13045 14 blasts blast NNS cord-005453-4057qib7 13045 15 and and CC cord-005453-4057qib7 13045 16 healthy healthy JJ cord-005453-4057qib7 13045 17 reference reference NN cord-005453-4057qib7 13045 18 tissue tissue NN cord-005453-4057qib7 13045 19 . . . cord-005453-4057qib7 13046 1 HLA HLA NNP cord-005453-4057qib7 13046 2 binding bind VBG cord-005453-4057qib7 13046 3 peptides peptide NNS cord-005453-4057qib7 13046 4 harboring harbor VBG cord-005453-4057qib7 13046 5 the the DT cord-005453-4057qib7 13046 6 altered alter VBN cord-005453-4057qib7 13046 7 amino amino JJ cord-005453-4057qib7 13046 8 acids acid NNS cord-005453-4057qib7 13046 9 are be VBP cord-005453-4057qib7 13046 10 subsequently subsequently RB cord-005453-4057qib7 13046 11 predicted predict VBN cord-005453-4057qib7 13046 12 in in IN cord-005453-4057qib7 13046 13 silico silico NNS cord-005453-4057qib7 13046 14 by by IN cord-005453-4057qib7 13046 15 algorithms algorithm NNS cord-005453-4057qib7 13046 16 SYFPEITHI SYFPEITHI NNP cord-005453-4057qib7 13046 17 , , , cord-005453-4057qib7 13047 1 NetMHC NetMHC NNP cord-005453-4057qib7 13047 2 and and CC cord-005453-4057qib7 13047 3 NetMHCpan NetMHCpan NNP cord-005453-4057qib7 13047 4 for for IN cord-005453-4057qib7 13047 5 the the DT cord-005453-4057qib7 13047 6 patients patient NNS cord-005453-4057qib7 13047 7 ' ' POS cord-005453-4057qib7 13047 8 individual individual JJ cord-005453-4057qib7 13047 9 HLA HLA NNP cord-005453-4057qib7 13047 10 type type NN cord-005453-4057qib7 13047 11 . . . cord-005453-4057qib7 13048 1 Vaccine vaccine NN cord-005453-4057qib7 13048 2 cocktails cocktail NNS cord-005453-4057qib7 13048 3 consisting consist VBG cord-005453-4057qib7 13048 4 of of IN cord-005453-4057qib7 13048 5 3 3 CD cord-005453-4057qib7 13048 6 - - SYM cord-005453-4057qib7 13048 7 5 5 CD cord-005453-4057qib7 13048 8 individual individual JJ cord-005453-4057qib7 13048 9 peptides peptide NNS cord-005453-4057qib7 13048 10 are be VBP cord-005453-4057qib7 13048 11 produced produce VBN cord-005453-4057qib7 13048 12 and and CC cord-005453-4057qib7 13048 13 formulated formulate VBN cord-005453-4057qib7 13048 14 under under IN cord-005453-4057qib7 13048 15 GMP GMP NNP cord-005453-4057qib7 13048 16 conditions condition NNS cord-005453-4057qib7 13048 17 . . . cord-005453-4057qib7 13049 1 The the DT cord-005453-4057qib7 13049 2 vaccination vaccination NN cord-005453-4057qib7 13049 3 schedule schedule NN cord-005453-4057qib7 13049 4 is be VBZ cord-005453-4057qib7 13049 5 16 16 CD cord-005453-4057qib7 13049 6 vaccinations vaccination NNS cord-005453-4057qib7 13049 7 over over IN cord-005453-4057qib7 13049 8 33 33 CD cord-005453-4057qib7 13049 9 weeks week NNS cord-005453-4057qib7 13049 10 using use VBG cord-005453-4057qib7 13049 11 GM GM NNP cord-005453-4057qib7 13049 12 - - HYPH cord-005453-4057qib7 13049 13 CSF CSF NNP cord-005453-4057qib7 13049 14 and and CC cord-005453-4057qib7 13049 15 Imiquimod Imiquimod NNP cord-005453-4057qib7 13049 16 as as IN cord-005453-4057qib7 13049 17 adjuvants adjuvant NNS cord-005453-4057qib7 13049 18 . . . cord-005453-4057qib7 13050 1 Response response NN cord-005453-4057qib7 13050 2 to to IN cord-005453-4057qib7 13050 3 the the DT cord-005453-4057qib7 13050 4 vaccination vaccination NN cord-005453-4057qib7 13050 5 is be VBZ cord-005453-4057qib7 13050 6 monitored monitor VBN cord-005453-4057qib7 13050 7 by by IN cord-005453-4057qib7 13050 8 detection detection NN cord-005453-4057qib7 13050 9 of of IN cord-005453-4057qib7 13050 10 T t NN cord-005453-4057qib7 13050 11 cells cell NNS cord-005453-4057qib7 13050 12 recognizing recognize VBG cord-005453-4057qib7 13050 13 the the DT cord-005453-4057qib7 13050 14 vaccinated vaccinate VBN cord-005453-4057qib7 13050 15 peptides peptide NNS cord-005453-4057qib7 13050 16 occurring occur VBG cord-005453-4057qib7 13050 17 over over IN cord-005453-4057qib7 13050 18 time time NN cord-005453-4057qib7 13050 19 in in IN cord-005453-4057qib7 13050 20 peripheral peripheral JJ cord-005453-4057qib7 13050 21 blood blood NN cord-005453-4057qib7 13050 22 of of IN cord-005453-4057qib7 13050 23 patients patient NNS cord-005453-4057qib7 13050 24 by by IN cord-005453-4057qib7 13050 25 prestimulation prestimulation NN cord-005453-4057qib7 13050 26 and and CC cord-005453-4057qib7 13050 27 intracellular intracellular JJ cord-005453-4057qib7 13050 28 cytokine cytokine NN cord-005453-4057qib7 13050 29 staining staining NN cord-005453-4057qib7 13050 30 . . . cord-005453-4057qib7 13051 1 Results result NNS cord-005453-4057qib7 13051 2 : : : cord-005453-4057qib7 13051 3 Until until IN cord-005453-4057qib7 13051 4 now now RB cord-005453-4057qib7 13051 5 , , , cord-005453-4057qib7 13051 6 23 23 CD cord-005453-4057qib7 13051 7 patients patient NNS cord-005453-4057qib7 13051 8 were be VBD cord-005453-4057qib7 13051 9 recruited recruit VBN cord-005453-4057qib7 13051 10 , , , cord-005453-4057qib7 13051 11 for for IN cord-005453-4057qib7 13051 12 17 17 CD cord-005453-4057qib7 13051 13 of of IN cord-005453-4057qib7 13051 14 those those DT cord-005453-4057qib7 13051 15 , , , cord-005453-4057qib7 13051 16 whole whole JJ cord-005453-4057qib7 13051 17 exome exome NN cord-005453-4057qib7 13051 18 sequencing sequencing NN cord-005453-4057qib7 13051 19 was be VBD cord-005453-4057qib7 13051 20 performed perform VBN cord-005453-4057qib7 13051 21 to to TO cord-005453-4057qib7 13051 22 identify identify VB cord-005453-4057qib7 13051 23 ALL all DT cord-005453-4057qib7 13051 24 - - HYPH cord-005453-4057qib7 13051 25 specific specific JJ cord-005453-4057qib7 13051 26 SNVs snv NNS cord-005453-4057qib7 13051 27 using use VBG cord-005453-4057qib7 13051 28 a a DT cord-005453-4057qib7 13051 29 comparative comparative JJ cord-005453-4057qib7 13051 30 bioinformatics bioinformatics NN cord-005453-4057qib7 13051 31 pipeline pipeline NN cord-005453-4057qib7 13051 32 . . . cord-005453-4057qib7 13052 1 We -PRON- PRP cord-005453-4057qib7 13052 2 found find VBD cord-005453-4057qib7 13052 3 an an DT cord-005453-4057qib7 13052 4 average average NN cord-005453-4057qib7 13052 5 of of IN cord-005453-4057qib7 13052 6 118.8 118.8 CD cord-005453-4057qib7 13052 7 mutations mutation NNS cord-005453-4057qib7 13052 8 per per IN cord-005453-4057qib7 13052 9 patient patient NN cord-005453-4057qib7 13052 10 on on IN cord-005453-4057qib7 13052 11 DNA dna NN cord-005453-4057qib7 13052 12 level level NN cord-005453-4057qib7 13052 13 . . . cord-005453-4057qib7 13053 1 Based base VBN cord-005453-4057qib7 13053 2 on on IN cord-005453-4057qib7 13053 3 these these DT cord-005453-4057qib7 13053 4 data datum NNS cord-005453-4057qib7 13053 5 , , , cord-005453-4057qib7 13053 6 an an DT cord-005453-4057qib7 13053 7 average average NN cord-005453-4057qib7 13053 8 of of IN cord-005453-4057qib7 13053 9 178 178 CD cord-005453-4057qib7 13053 10 HLA HLA NNP cord-005453-4057qib7 13053 11 binders binder NNS cord-005453-4057qib7 13053 12 derived derive VBN cord-005453-4057qib7 13053 13 from from IN cord-005453-4057qib7 13053 14 neoantigens neoantigen NNS cord-005453-4057qib7 13053 15 could could MD cord-005453-4057qib7 13053 16 be be VB cord-005453-4057qib7 13053 17 predicted predict VBN cord-005453-4057qib7 13053 18 per per IN cord-005453-4057qib7 13053 19 patient patient NN cord-005453-4057qib7 13053 20 . . . cord-005453-4057qib7 13054 1 An an DT cord-005453-4057qib7 13054 2 average average JJ cord-005453-4057qib7 13054 3 expression expression NN cord-005453-4057qib7 13054 4 of of IN cord-005453-4057qib7 13054 5 34.4 34.4 CD cord-005453-4057qib7 13054 6 % % NN cord-005453-4057qib7 13054 7 of of IN cord-005453-4057qib7 13054 8 mutations mutation NNS cord-005453-4057qib7 13054 9 was be VBD cord-005453-4057qib7 13054 10 assessed assess VBN cord-005453-4057qib7 13054 11 by by IN cord-005453-4057qib7 13054 12 RNA RNA NNP cord-005453-4057qib7 13054 13 sequencing sequencing NN cord-005453-4057qib7 13054 14 . . . cord-005453-4057qib7 13055 1 In in IN cord-005453-4057qib7 13055 2 all all DT cord-005453-4057qib7 13055 3 cases case NNS cord-005453-4057qib7 13055 4 validated validate VBN cord-005453-4057qib7 13055 5 mutations mutation NNS cord-005453-4057qib7 13055 6 could could MD cord-005453-4057qib7 13055 7 be be VB cord-005453-4057qib7 13055 8 identified identify VBN cord-005453-4057qib7 13055 9 and and CC cord-005453-4057qib7 13055 10 cocktail cocktail NN cord-005453-4057qib7 13055 11 design design NN cord-005453-4057qib7 13055 12 was be VBD cord-005453-4057qib7 13055 13 feasible feasible JJ cord-005453-4057qib7 13055 14 . . . cord-005453-4057qib7 13056 1 Until until IN cord-005453-4057qib7 13056 2 now now RB cord-005453-4057qib7 13056 3 , , , cord-005453-4057qib7 13056 4 4 4 CD cord-005453-4057qib7 13056 5 patients patient NNS cord-005453-4057qib7 13056 6 received receive VBD cord-005453-4057qib7 13056 7 vaccinations vaccination NNS cord-005453-4057qib7 13056 8 . . . cord-005453-4057qib7 13057 1 The the DT cord-005453-4057qib7 13057 2 vaccine vaccine NN cord-005453-4057qib7 13057 3 was be VBD cord-005453-4057qib7 13057 4 generally generally RB cord-005453-4057qib7 13057 5 well well RB cord-005453-4057qib7 13057 6 tolerated tolerate VBN cord-005453-4057qib7 13057 7 and and CC cord-005453-4057qib7 13057 8 no no UH cord-005453-4057qib7 13057 9 or or CC cord-005453-4057qib7 13057 10 only only RB cord-005453-4057qib7 13057 11 mild mild JJ cord-005453-4057qib7 13057 12 side side NN cord-005453-4057qib7 13057 13 effects effect NNS cord-005453-4057qib7 13057 14 were be VBD cord-005453-4057qib7 13057 15 observed observe VBN cord-005453-4057qib7 13057 16 . . . cord-005453-4057qib7 13058 1 Immune immune JJ cord-005453-4057qib7 13058 2 monitoring monitoring NN cord-005453-4057qib7 13058 3 was be VBD cord-005453-4057qib7 13058 4 performed perform VBN cord-005453-4057qib7 13058 5 for for IN cord-005453-4057qib7 13058 6 2 2 CD cord-005453-4057qib7 13058 7 patients patient NNS cord-005453-4057qib7 13058 8 until until IN cord-005453-4057qib7 13058 9 now now RB cord-005453-4057qib7 13058 10 . . . cord-005453-4057qib7 13059 1 In in IN cord-005453-4057qib7 13059 2 the the DT cord-005453-4057qib7 13059 3 first first JJ cord-005453-4057qib7 13059 4 patient patient NN cord-005453-4057qib7 13059 5 , , , cord-005453-4057qib7 13059 6 we -PRON- PRP cord-005453-4057qib7 13059 7 observed observe VBD cord-005453-4057qib7 13059 8 a a DT cord-005453-4057qib7 13059 9 transient transient JJ cord-005453-4057qib7 13059 10 CD4 CD4 NNP cord-005453-4057qib7 13059 11 + + CC cord-005453-4057qib7 13059 12 response response NN cord-005453-4057qib7 13059 13 against against IN cord-005453-4057qib7 13059 14 one one CD cord-005453-4057qib7 13059 15 vaccinated vaccinate VBN cord-005453-4057qib7 13059 16 MHC MHC NNP cord-005453-4057qib7 13059 17 Class Class NNP cord-005453-4057qib7 13059 18 II II NNP cord-005453-4057qib7 13059 19 ligand ligand NN cord-005453-4057qib7 13059 20 and and CC cord-005453-4057qib7 13059 21 a a DT cord-005453-4057qib7 13059 22 sustained sustained JJ cord-005453-4057qib7 13059 23 CD4 CD4 NNP cord-005453-4057qib7 13059 24 + + CC cord-005453-4057qib7 13059 25 response response NN cord-005453-4057qib7 13059 26 against against IN cord-005453-4057qib7 13059 27 the the DT cord-005453-4057qib7 13059 28 included include VBN cord-005453-4057qib7 13059 29 wildtype wildtype NN cord-005453-4057qib7 13059 30 control control NN cord-005453-4057qib7 13059 31 peptide peptide NN cord-005453-4057qib7 13059 32 derived derive VBN cord-005453-4057qib7 13059 33 from from IN cord-005453-4057qib7 13059 34 the the DT cord-005453-4057qib7 13059 35 antigen antigen NN cord-005453-4057qib7 13059 36 Survivin Survivin NNP cord-005453-4057qib7 13059 37 . . . cord-005453-4057qib7 13060 1 In in IN cord-005453-4057qib7 13060 2 the the DT cord-005453-4057qib7 13060 3 second second JJ cord-005453-4057qib7 13060 4 patient patient NN cord-005453-4057qib7 13060 5 , , , cord-005453-4057qib7 13060 6 immune immune JJ cord-005453-4057qib7 13060 7 monitoring monitoring NN cord-005453-4057qib7 13060 8 was be VBD cord-005453-4057qib7 13060 9 performed perform VBN cord-005453-4057qib7 13060 10 for for IN cord-005453-4057qib7 13060 11 the the DT cord-005453-4057qib7 13060 12 first first JJ cord-005453-4057qib7 13060 13 8 8 CD cord-005453-4057qib7 13060 14 vaccination vaccination NN cord-005453-4057qib7 13060 15 timepoints timepoint NNS cord-005453-4057qib7 13060 16 , , , cord-005453-4057qib7 13060 17 a a DT cord-005453-4057qib7 13060 18 T T NNP cord-005453-4057qib7 13060 19 cell cell NN cord-005453-4057qib7 13060 20 response response NN cord-005453-4057qib7 13060 21 was be VBD cord-005453-4057qib7 13060 22 not not RB cord-005453-4057qib7 13060 23 measurable measurable JJ cord-005453-4057qib7 13060 24 at at IN cord-005453-4057qib7 13060 25 this this DT cord-005453-4057qib7 13060 26 timepoint timepoint NN cord-005453-4057qib7 13060 27 of of IN cord-005453-4057qib7 13060 28 vaccination vaccination NN cord-005453-4057qib7 13060 29 . . . cord-005453-4057qib7 13061 1 Conclusions conclusion NNS cord-005453-4057qib7 13061 2 : : : cord-005453-4057qib7 13062 1 Whole whole JJ cord-005453-4057qib7 13062 2 exome exome NN cord-005453-4057qib7 13062 3 sequencing sequencing NN cord-005453-4057qib7 13062 4 of of IN cord-005453-4057qib7 13062 5 pediatric pediatric JJ cord-005453-4057qib7 13062 6 ALL all DT cord-005453-4057qib7 13062 7 patients patient NNS cord-005453-4057qib7 13062 8 is be VBZ cord-005453-4057qib7 13062 9 feasible feasible JJ cord-005453-4057qib7 13062 10 and and CC cord-005453-4057qib7 13062 11 yields yield VBZ cord-005453-4057qib7 13062 12 small small JJ cord-005453-4057qib7 13062 13 amounts amount NNS cord-005453-4057qib7 13062 14 of of IN cord-005453-4057qib7 13062 15 expressed express VBN cord-005453-4057qib7 13062 16 , , , cord-005453-4057qib7 13062 17 tumor tumor NN cord-005453-4057qib7 13062 18 - - HYPH cord-005453-4057qib7 13062 19 specific specific JJ cord-005453-4057qib7 13062 20 mutations mutation NNS cord-005453-4057qib7 13062 21 . . . cord-005453-4057qib7 13063 1 These these DT cord-005453-4057qib7 13063 2 few few JJ cord-005453-4057qib7 13063 3 mutations mutation NNS cord-005453-4057qib7 13063 4 are be VBP cord-005453-4057qib7 13063 5 sufficient sufficient JJ cord-005453-4057qib7 13063 6 to to TO cord-005453-4057qib7 13063 7 predict predict VB cord-005453-4057qib7 13063 8 HLA HLA NNP cord-005453-4057qib7 13063 9 - - HYPH cord-005453-4057qib7 13063 10 binding bind VBG cord-005453-4057qib7 13063 11 peptides peptide NNS cord-005453-4057qib7 13063 12 that that WDT cord-005453-4057qib7 13063 13 can can MD cord-005453-4057qib7 13063 14 be be VB cord-005453-4057qib7 13063 15 used use VBN cord-005453-4057qib7 13063 16 to to TO cord-005453-4057qib7 13063 17 formulate formulate VB cord-005453-4057qib7 13063 18 individualized individualized JJ cord-005453-4057qib7 13063 19 peptide peptide JJ cord-005453-4057qib7 13063 20 vaccine vaccine NN cord-005453-4057qib7 13063 21 cocktails cocktail NNS cord-005453-4057qib7 13063 22 . . . cord-005453-4057qib7 13064 1 We -PRON- PRP cord-005453-4057qib7 13064 2 currently currently RB cord-005453-4057qib7 13064 3 conduct conduct VBP cord-005453-4057qib7 13064 4 a a DT cord-005453-4057qib7 13064 5 clinical clinical JJ cord-005453-4057qib7 13064 6 phase phase NN cord-005453-4057qib7 13064 7 I I NNP cord-005453-4057qib7 13064 8 / / SYM cord-005453-4057qib7 13064 9 II II NNP cord-005453-4057qib7 13064 10 trial trial NN cord-005453-4057qib7 13064 11 in in IN cord-005453-4057qib7 13064 12 a a DT cord-005453-4057qib7 13064 13 small small JJ cord-005453-4057qib7 13064 14 cohort cohort NN cord-005453-4057qib7 13064 15 of of IN cord-005453-4057qib7 13064 16 high high JJ cord-005453-4057qib7 13064 17 - - HYPH cord-005453-4057qib7 13064 18 risk risk NN cord-005453-4057qib7 13064 19 ALL all DT cord-005453-4057qib7 13064 20 patients patient NNS cord-005453-4057qib7 13064 21 to to TO cord-005453-4057qib7 13064 22 assess assess VB cord-005453-4057qib7 13064 23 safety safety NN cord-005453-4057qib7 13064 24 , , , cord-005453-4057qib7 13064 25 toxicity toxicity NN cord-005453-4057qib7 13064 26 and and CC cord-005453-4057qib7 13064 27 immunogenicity immunogenicity NN cord-005453-4057qib7 13064 28 . . . cord-005453-4057qib7 13065 1 Clinical clinical JJ cord-005453-4057qib7 13065 2 Background background NN cord-005453-4057qib7 13065 3 : : : cord-005453-4057qib7 13066 1 Chimeric chimeric JJ cord-005453-4057qib7 13066 2 antigen antigen NN cord-005453-4057qib7 13066 3 receptor receptor NN cord-005453-4057qib7 13066 4 T t NN cord-005453-4057qib7 13066 5 cells cell NNS cord-005453-4057qib7 13066 6 ( ( -LRB- cord-005453-4057qib7 13066 7 CART cart NN cord-005453-4057qib7 13066 8 ) ) -RRB- cord-005453-4057qib7 13066 9 are be VBP cord-005453-4057qib7 13066 10 considered consider VBN cord-005453-4057qib7 13066 11 as as IN cord-005453-4057qib7 13066 12 gene gene NN cord-005453-4057qib7 13066 13 therapy therapy NN cord-005453-4057qib7 13066 14 medicinal medicinal JJ cord-005453-4057qib7 13066 15 products product NNS cord-005453-4057qib7 13066 16 ( ( -LRB- cord-005453-4057qib7 13066 17 GTMP GTMP NNP cord-005453-4057qib7 13066 18 ) ) -RRB- cord-005453-4057qib7 13066 19 and and CC cord-005453-4057qib7 13066 20 genetically genetically RB cord-005453-4057qib7 13066 21 modified modify VBN cord-005453-4057qib7 13066 22 organisms organism NNS cord-005453-4057qib7 13066 23 ( ( -LRB- cord-005453-4057qib7 13066 24 GMO GMO NNP cord-005453-4057qib7 13066 25 ) ) -RRB- cord-005453-4057qib7 13066 26 . . . cord-005453-4057qib7 13067 1 Hence hence RB cord-005453-4057qib7 13067 2 , , , cord-005453-4057qib7 13067 3 CARTs cart NNS cord-005453-4057qib7 13067 4 manufacturing manufacture VBG cord-005453-4057qib7 13067 5 for for IN cord-005453-4057qib7 13067 6 clinical clinical JJ cord-005453-4057qib7 13067 7 application application NN cord-005453-4057qib7 13067 8 is be VBZ cord-005453-4057qib7 13067 9 strictly strictly RB cord-005453-4057qib7 13067 10 regulated regulate VBN cord-005453-4057qib7 13067 11 . . . cord-005453-4057qib7 13068 1 Appropriate appropriate JJ cord-005453-4057qib7 13068 2 methods method NNS cord-005453-4057qib7 13068 3 assessing assess VBG cord-005453-4057qib7 13068 4 CAR car NN cord-005453-4057qib7 13068 5 transgene transgene NN cord-005453-4057qib7 13068 6 copy copy NN cord-005453-4057qib7 13068 7 number number NN cord-005453-4057qib7 13068 8 ( ( -LRB- cord-005453-4057qib7 13068 9 CN CN NNP cord-005453-4057qib7 13068 10 ) ) -RRB- cord-005453-4057qib7 13068 11 in in IN cord-005453-4057qib7 13068 12 a a DT cord-005453-4057qib7 13068 13 CART cart NN cord-005453-4057qib7 13068 14 product product NN cord-005453-4057qib7 13068 15 and and CC cord-005453-4057qib7 13068 16 definition definition NN cord-005453-4057qib7 13068 17 of of IN cord-005453-4057qib7 13068 18 the the DT cord-005453-4057qib7 13068 19 frequency frequency NN cord-005453-4057qib7 13068 20 of of IN cord-005453-4057qib7 13068 21 CARTs cart NNS cord-005453-4057qib7 13068 22 in in IN cord-005453-4057qib7 13068 23 treated treat VBN cord-005453-4057qib7 13068 24 CART cart NN cord-005453-4057qib7 13068 25 patient patient NN cord-005453-4057qib7 13068 26 are be VBP cord-005453-4057qib7 13068 27 mandatory mandatory JJ cord-005453-4057qib7 13068 28 . . . cord-005453-4057qib7 13069 1 Although although IN cord-005453-4057qib7 13069 2 quantitative quantitative JJ cord-005453-4057qib7 13069 3 real real JJ cord-005453-4057qib7 13069 4 - - HYPH cord-005453-4057qib7 13069 5 time time NN cord-005453-4057qib7 13069 6 PCR pcr NN cord-005453-4057qib7 13069 7 - - HYPH cord-005453-4057qib7 13069 8 based base VBN cord-005453-4057qib7 13069 9 ( ( -LRB- cord-005453-4057qib7 13069 10 qPCR qPCR NNP cord-005453-4057qib7 13069 11 ) ) -RRB- cord-005453-4057qib7 13069 12 analysis analysis NN cord-005453-4057qib7 13069 13 has have VBZ cord-005453-4057qib7 13069 14 been be VBN cord-005453-4057qib7 13069 15 used use VBN cord-005453-4057qib7 13069 16 for for IN cord-005453-4057qib7 13069 17 this this DT cord-005453-4057qib7 13069 18 purpose purpose NN cord-005453-4057qib7 13069 19 , , , cord-005453-4057qib7 13069 20 no no DT cord-005453-4057qib7 13069 21 standardized standardized JJ cord-005453-4057qib7 13069 22 procedure procedure NN cord-005453-4057qib7 13069 23 to to TO cord-005453-4057qib7 13069 24 minimize minimize VB cord-005453-4057qib7 13069 25 systematic systematic JJ cord-005453-4057qib7 13069 26 errors error NNS cord-005453-4057qib7 13069 27 and and CC cord-005453-4057qib7 13069 28 enable enable VB cord-005453-4057qib7 13069 29 comparability comparability NN cord-005453-4057qib7 13069 30 has have VBZ cord-005453-4057qib7 13069 31 been be VBN cord-005453-4057qib7 13069 32 established establish VBN cord-005453-4057qib7 13069 33 yet yet RB cord-005453-4057qib7 13069 34 . . . cord-005453-4057qib7 13070 1 Here here RB cord-005453-4057qib7 13070 2 , , , cord-005453-4057qib7 13070 3 we -PRON- PRP cord-005453-4057qib7 13070 4 report report VBP cord-005453-4057qib7 13070 5 on on IN cord-005453-4057qib7 13070 6 a a DT cord-005453-4057qib7 13070 7 single single JJ cord-005453-4057qib7 13070 8 copy copy NN cord-005453-4057qib7 13070 9 genebased genebased NN cord-005453-4057qib7 13070 10 ( ( -LRB- cord-005453-4057qib7 13070 11 SCG SCG NNP cord-005453-4057qib7 13070 12 ) ) -RRB- cord-005453-4057qib7 13070 13 duplex duplex NNP cord-005453-4057qib7 13070 14 ( ( -LRB- cord-005453-4057qib7 13070 15 DP DP NNP cord-005453-4057qib7 13070 16 ) ) -RRB- cord-005453-4057qib7 13070 17 PCR PCR NNP cord-005453-4057qib7 13070 18 ( ( -LRB- cord-005453-4057qib7 13070 19 SCG SCG NNP cord-005453-4057qib7 13070 20 - - HYPH cord-005453-4057qib7 13070 21 DP DP NNP cord-005453-4057qib7 13070 22 - - HYPH cord-005453-4057qib7 13070 23 PCR PCR NNP cord-005453-4057qib7 13070 24 ) ) -RRB- cord-005453-4057qib7 13070 25 for for IN cord-005453-4057qib7 13070 26 the the DT cord-005453-4057qib7 13070 27 determination determination NN cord-005453-4057qib7 13070 28 of of IN cord-005453-4057qib7 13070 29 the the DT cord-005453-4057qib7 13070 30 vector vector NN cord-005453-4057qib7 13070 31 copy copy NN cord-005453-4057qib7 13070 32 number number NN cord-005453-4057qib7 13070 33 ( ( -LRB- cord-005453-4057qib7 13070 34 VCN VCN NNP cord-005453-4057qib7 13070 35 ) ) -RRB- cord-005453-4057qib7 13070 36 in in IN cord-005453-4057qib7 13070 37 CART cart NN cord-005453-4057qib7 13070 38 products product NNS cord-005453-4057qib7 13070 39 as as RB cord-005453-4057qib7 13070 40 well well RB cord-005453-4057qib7 13070 41 as as IN cord-005453-4057qib7 13070 42 patient patient NN cord-005453-4057qib7 13070 43 samples sample NNS cord-005453-4057qib7 13070 44 following follow VBG cord-005453-4057qib7 13070 45 CART CART NNP cord-005453-4057qib7 13070 46 administration administration NN cord-005453-4057qib7 13070 47 . . . cord-005453-4057qib7 13071 1 SCG SCG NNP cord-005453-4057qib7 13071 2 - - HYPH cord-005453-4057qib7 13071 3 DP DP NNP cord-005453-4057qib7 13071 4 - - HYPH cord-005453-4057qib7 13071 5 PCR PCR NNP cord-005453-4057qib7 13071 6 was be VBD cord-005453-4057qib7 13071 7 validated validate VBN cord-005453-4057qib7 13071 8 and and CC cord-005453-4057qib7 13071 9 compared compare VBN cord-005453-4057qib7 13071 10 to to IN cord-005453-4057qib7 13071 11 the the DT cord-005453-4057qib7 13071 12 broadly broadly RB cord-005453-4057qib7 13071 13 used use VBN cord-005453-4057qib7 13071 14 absolute absolute JJ cord-005453-4057qib7 13071 15 copy copy NN cord-005453-4057qib7 13071 16 number number NN cord-005453-4057qib7 13071 17 qPCR qpcr NN cord-005453-4057qib7 13071 18 ( ( -LRB- cord-005453-4057qib7 13071 19 ACN ACN NNP cord-005453-4057qib7 13071 20 ) ) -RRB- cord-005453-4057qib7 13071 21 approach approach NN cord-005453-4057qib7 13071 22 within within IN cord-005453-4057qib7 13071 23 the the DT cord-005453-4057qib7 13071 24 framework framework NN cord-005453-4057qib7 13071 25 of of IN cord-005453-4057qib7 13071 26 a a DT cord-005453-4057qib7 13071 27 clinical clinical JJ cord-005453-4057qib7 13071 28 trial trial NN cord-005453-4057qib7 13071 29 treating treat VBG cord-005453-4057qib7 13071 30 patients patient NNS cord-005453-4057qib7 13071 31 with with IN cord-005453-4057qib7 13071 32 good good JJ cord-005453-4057qib7 13071 33 manufacturing manufacturing NN cord-005453-4057qib7 13071 34 practice practice NN cord-005453-4057qib7 13071 35 ( ( -LRB- cord-005453-4057qib7 13071 36 GMP)-grade GMP)-grade NNP cord-005453-4057qib7 13071 37 CARTs cart NNS cord-005453-4057qib7 13071 38 ( ( -LRB- cord-005453-4057qib7 13071 39 HD HD NNP cord-005453-4057qib7 13071 40 - - HYPH cord-005453-4057qib7 13071 41 CAR-1 CAR-1 NNP cord-005453-4057qib7 13071 42 ) ) -RRB- cord-005453-4057qib7 13071 43 . . . cord-005453-4057qib7 13072 1 Methods method NNS cord-005453-4057qib7 13072 2 : : : cord-005453-4057qib7 13072 3 For for IN cord-005453-4057qib7 13072 4 conventional conventional JJ cord-005453-4057qib7 13072 5 ACN ACN NNP cord-005453-4057qib7 13072 6 , , , cord-005453-4057qib7 13072 7 primers primer NNS cord-005453-4057qib7 13072 8 and and CC cord-005453-4057qib7 13072 9 probe probe NN cord-005453-4057qib7 13072 10 targeting target VBG cord-005453-4057qib7 13072 11 the the DT cord-005453-4057qib7 13072 12 CAR car NN cord-005453-4057qib7 13072 13 vector vector NN cord-005453-4057qib7 13072 14 RV rv NN cord-005453-4057qib7 13072 15 - - HYPH cord-005453-4057qib7 13072 16 SFG.CD19.CD28.4 SFG.CD19.CD28.4 NNP cord-005453-4057qib7 13072 17 - - HYPH cord-005453-4057qib7 13072 18 1BBzeta 1BBzeta NNP cord-005453-4057qib7 13072 19 were be VBD cord-005453-4057qib7 13072 20 designed design VBN cord-005453-4057qib7 13072 21 . . . cord-005453-4057qib7 13073 1 Standard standard JJ cord-005453-4057qib7 13073 2 curves curve NNS cord-005453-4057qib7 13073 3 were be VBD cord-005453-4057qib7 13073 4 established establish VBN cord-005453-4057qib7 13073 5 via via IN cord-005453-4057qib7 13073 6 serial serial JJ cord-005453-4057qib7 13073 7 dilutions dilution NNS cord-005453-4057qib7 13073 8 of of IN cord-005453-4057qib7 13073 9 the the DT cord-005453-4057qib7 13073 10 SFG.CAR SFG.CAR NNP cord-005453-4057qib7 13073 11 plasmid plasmid NN cord-005453-4057qib7 13073 12 . . . cord-005453-4057qib7 13074 1 Amplification amplification NN cord-005453-4057qib7 13074 2 of of IN cord-005453-4057qib7 13074 3 the the DT cord-005453-4057qib7 13074 4 standard standard JJ cord-005453-4057qib7 13074 5 curve curve NN cord-005453-4057qib7 13074 6 as as RB cord-005453-4057qib7 13074 7 well well RB cord-005453-4057qib7 13074 8 as as IN cord-005453-4057qib7 13074 9 target target NN cord-005453-4057qib7 13074 10 genomic genomic JJ cord-005453-4057qib7 13074 11 DNA dna NN cord-005453-4057qib7 13074 12 for for IN cord-005453-4057qib7 13074 13 VCNdetermination vcndetermination NN cord-005453-4057qib7 13074 14 was be VBD cord-005453-4057qib7 13074 15 performed perform VBN cord-005453-4057qib7 13074 16 as as IN cord-005453-4057qib7 13074 17 singleplex singleplex NN cord-005453-4057qib7 13074 18 ( ( -LRB- cord-005453-4057qib7 13074 19 SP SP NNP cord-005453-4057qib7 13074 20 ) ) -RRB- cord-005453-4057qib7 13074 21 PCR PCR NNP cord-005453-4057qib7 13074 22 ( ( -LRB- cord-005453-4057qib7 13074 23 SP SP NNP cord-005453-4057qib7 13074 24 - - HYPH cord-005453-4057qib7 13074 25 CAR CAR NNP cord-005453-4057qib7 13074 26 ) ) -RRB- cord-005453-4057qib7 13074 27 ( ( -LRB- cord-005453-4057qib7 13074 28 method method NN cord-005453-4057qib7 13074 29 A A NNP cord-005453-4057qib7 13074 30 ) ) -RRB- cord-005453-4057qib7 13074 31 . . . cord-005453-4057qib7 13075 1 On on IN cord-005453-4057qib7 13075 2 the the DT cord-005453-4057qib7 13075 3 same same JJ cord-005453-4057qib7 13075 4 qPCR qpcr NN cord-005453-4057qib7 13075 5 plate plate NN cord-005453-4057qib7 13075 6 , , , cord-005453-4057qib7 13075 7 duplex duplex NNP cord-005453-4057qib7 13075 8 ( ( -LRB- cord-005453-4057qib7 13075 9 DP DP NNP cord-005453-4057qib7 13075 10 ) ) -RRB- cord-005453-4057qib7 13075 11 qPCR qpcr NN cord-005453-4057qib7 13075 12 reactions reaction NNS cord-005453-4057qib7 13075 13 were be VBD cord-005453-4057qib7 13075 14 carried carry VBN cord-005453-4057qib7 13075 15 out out RP cord-005453-4057qib7 13075 16 . . . cord-005453-4057qib7 13076 1 Additionally additionally RB cord-005453-4057qib7 13076 2 to to IN cord-005453-4057qib7 13076 3 the the DT cord-005453-4057qib7 13076 4 components component NNS cord-005453-4057qib7 13076 5 comprised comprise VBN cord-005453-4057qib7 13076 6 within within IN cord-005453-4057qib7 13076 7 method method NN cord-005453-4057qib7 13076 8 A A NNP cord-005453-4057qib7 13076 9 , , , cord-005453-4057qib7 13076 10 the the DT cord-005453-4057qib7 13076 11 experimental experimental JJ cord-005453-4057qib7 13076 12 setup setup NN cord-005453-4057qib7 13076 13 contained contain VBD cord-005453-4057qib7 13076 14 haploid haploid JJ cord-005453-4057qib7 13076 15 human human JJ cord-005453-4057qib7 13076 16 genomes genome NNS cord-005453-4057qib7 13076 17 as as RB cord-005453-4057qib7 13076 18 well well RB cord-005453-4057qib7 13076 19 as as IN cord-005453-4057qib7 13076 20 primers primer NNS cord-005453-4057qib7 13076 21 and and CC cord-005453-4057qib7 13076 22 probe probe NN cord-005453-4057qib7 13076 23 targeting target VBG cord-005453-4057qib7 13076 24 ribonuclease ribonuclease NN cord-005453-4057qib7 13076 25 ( ( -LRB- cord-005453-4057qib7 13076 26 RNAse RNAse NNP cord-005453-4057qib7 13076 27 ) ) -RRB- cord-005453-4057qib7 13076 28 P p NN cord-005453-4057qib7 13076 29 as as IN cord-005453-4057qib7 13076 30 human human JJ cord-005453-4057qib7 13076 31 SCG SCG NNP cord-005453-4057qib7 13076 32 . . . cord-005453-4057qib7 13077 1 The the DT cord-005453-4057qib7 13077 2 amplifications amplification NNS cord-005453-4057qib7 13077 3 for for IN cord-005453-4057qib7 13077 4 the the DT cord-005453-4057qib7 13077 5 SFG.CAR SFG.CAR NNP cord-005453-4057qib7 13077 6 plasmid plasmid NN cord-005453-4057qib7 13077 7 ( ( -LRB- cord-005453-4057qib7 13077 8 DP dp NN cord-005453-4057qib7 13077 9 - - HYPH cord-005453-4057qib7 13077 10 CAR CAR NNP cord-005453-4057qib7 13077 11 ) ) -RRB- cord-005453-4057qib7 13077 12 and and CC cord-005453-4057qib7 13077 13 the the DT cord-005453-4057qib7 13077 14 RNAseP RNAseP NNP cord-005453-4057qib7 13077 15 gene gene NN cord-005453-4057qib7 13077 16 ( ( -LRB- cord-005453-4057qib7 13077 17 DP DP NNP cord-005453-4057qib7 13077 18 - - HYPH cord-005453-4057qib7 13077 19 RNAseP RNAseP NNP cord-005453-4057qib7 13077 20 ) ) -RRB- cord-005453-4057qib7 13077 21 were be VBD cord-005453-4057qib7 13077 22 performed perform VBN cord-005453-4057qib7 13077 23 simultaneously simultaneously RB cord-005453-4057qib7 13077 24 ( ( -LRB- cord-005453-4057qib7 13077 25 SCG SCG NNP cord-005453-4057qib7 13077 26 - - HYPH cord-005453-4057qib7 13077 27 DP DP NNP cord-005453-4057qib7 13077 28 - - HYPH cord-005453-4057qib7 13077 29 PCR pcr NN cord-005453-4057qib7 13077 30 ; ; : cord-005453-4057qib7 13077 31 method method NN cord-005453-4057qib7 13077 32 B b NN cord-005453-4057qib7 13077 33 ) ) -RRB- cord-005453-4057qib7 13077 34 . . . cord-005453-4057qib7 13078 1 SCG SCG NNP cord-005453-4057qib7 13078 2 - - HYPH cord-005453-4057qib7 13078 3 DP DP NNP cord-005453-4057qib7 13078 4 - - HYPH cord-005453-4057qib7 13078 5 PCR PCR NNP cord-005453-4057qib7 13078 6 was be VBD cord-005453-4057qib7 13078 7 performed perform VBN cord-005453-4057qib7 13078 8 for for IN cord-005453-4057qib7 13078 9 standard standard JJ cord-005453-4057qib7 13078 10 curves curve NNS cord-005453-4057qib7 13078 11 and and CC cord-005453-4057qib7 13078 12 target target NN cord-005453-4057qib7 13078 13 samples sample NNS cord-005453-4057qib7 13078 14 . . . cord-005453-4057qib7 13079 1 Target target NN cord-005453-4057qib7 13079 2 - - HYPH cord-005453-4057qib7 13079 3 sample sample NN cord-005453-4057qib7 13079 4 DNA dna NN cord-005453-4057qib7 13079 5 was be VBD cord-005453-4057qib7 13079 6 extracted extract VBN cord-005453-4057qib7 13079 7 from from IN cord-005453-4057qib7 13079 8 CARTs cart NNS cord-005453-4057qib7 13079 9 prepared prepare VBN cord-005453-4057qib7 13079 10 from from IN cord-005453-4057qib7 13079 11 leukapheresis leukapheresis NN cord-005453-4057qib7 13079 12 products product NNS cord-005453-4057qib7 13079 13 of of IN cord-005453-4057qib7 13079 14 three three CD cord-005453-4057qib7 13079 15 healthy healthy JJ cord-005453-4057qib7 13079 16 donors donor NNS cord-005453-4057qib7 13079 17 ( ( -LRB- cord-005453-4057qib7 13079 18 HD HD NNP cord-005453-4057qib7 13079 19 ) ) -RRB- cord-005453-4057qib7 13079 20 . . . cord-005453-4057qib7 13080 1 Results result NNS cord-005453-4057qib7 13080 2 : : : cord-005453-4057qib7 13081 1 For for IN cord-005453-4057qib7 13081 2 method method NN cord-005453-4057qib7 13081 3 validation validation NN cord-005453-4057qib7 13081 4 , , , cord-005453-4057qib7 13081 5 efficiency efficiency NN cord-005453-4057qib7 13081 6 and and CC cord-005453-4057qib7 13081 7 linearity linearity NN cord-005453-4057qib7 13081 8 ( ( -LRB- cord-005453-4057qib7 13081 9 correlation correlation NN cord-005453-4057qib7 13081 10 coefficient coefficient NN cord-005453-4057qib7 13081 11 ) ) -RRB- cord-005453-4057qib7 13081 12 of of IN cord-005453-4057qib7 13081 13 the the DT cord-005453-4057qib7 13081 14 qPCR qpcr JJ cord-005453-4057qib7 13081 15 reactions reaction NNS cord-005453-4057qib7 13081 16 of of IN cord-005453-4057qib7 13081 17 method method NN cord-005453-4057qib7 13081 18 A a NN cord-005453-4057qib7 13081 19 ( ( -LRB- cord-005453-4057qib7 13081 20 SP SP NNP cord-005453-4057qib7 13081 21 - - HYPH cord-005453-4057qib7 13081 22 CAR CAR NNP cord-005453-4057qib7 13081 23 ) ) -RRB- cord-005453-4057qib7 13081 24 and and CC cord-005453-4057qib7 13081 25 method method NN cord-005453-4057qib7 13081 26 B b NN cord-005453-4057qib7 13081 27 ( ( -LRB- cord-005453-4057qib7 13081 28 DP dp NN cord-005453-4057qib7 13081 29 - - HYPH cord-005453-4057qib7 13081 30 CAR car NN cord-005453-4057qib7 13081 31 , , , cord-005453-4057qib7 13081 32 DP DP NNP cord-005453-4057qib7 13081 33 - - HYPH cord-005453-4057qib7 13081 34 RNAseP RNAseP NNP cord-005453-4057qib7 13081 35 ) ) -RRB- cord-005453-4057qib7 13081 36 were be VBD cord-005453-4057qib7 13081 37 assessed assess VBN cord-005453-4057qib7 13081 38 by by IN cord-005453-4057qib7 13081 39 linear linear JJ cord-005453-4057qib7 13081 40 regression regression NN cord-005453-4057qib7 13081 41 of of IN cord-005453-4057qib7 13081 42 the the DT cord-005453-4057qib7 13081 43 PCR PCR NNP cord-005453-4057qib7 13081 44 signal signal NN cord-005453-4057qib7 13081 45 to to IN cord-005453-4057qib7 13081 46 the the DT cord-005453-4057qib7 13081 47 reference reference NN cord-005453-4057qib7 13081 48 standard standard JJ cord-005453-4057qib7 13081 49 curve curve NN cord-005453-4057qib7 13081 50 . . . cord-005453-4057qib7 13082 1 Overall overall RB cord-005453-4057qib7 13082 2 , , , cord-005453-4057qib7 13082 3 standard standard JJ cord-005453-4057qib7 13082 4 curves curve NNS cord-005453-4057qib7 13082 5 were be VBD cord-005453-4057qib7 13082 6 only only RB cord-005453-4057qib7 13082 7 considered consider VBN cord-005453-4057qib7 13082 8 valid valid JJ cord-005453-4057qib7 13082 9 if if IN cord-005453-4057qib7 13082 10 a a DT cord-005453-4057qib7 13082 11 correlation correlation NN cord-005453-4057qib7 13082 12 coefficient coefficient NN cord-005453-4057qib7 13082 13 ( ( -LRB- cord-005453-4057qib7 13082 14 R r NN cord-005453-4057qib7 13082 15 2 2 CD cord-005453-4057qib7 13082 16 ) ) -RRB- cord-005453-4057qib7 13082 17 of of IN cord-005453-4057qib7 13082 18 above above IN cord-005453-4057qib7 13082 19 0.98 0.98 CD cord-005453-4057qib7 13082 20 and and CC cord-005453-4057qib7 13082 21 efficiencies efficiency NNS cord-005453-4057qib7 13082 22 of of IN cord-005453-4057qib7 13082 23 100 100 CD cord-005453-4057qib7 13082 24 % % NN cord-005453-4057qib7 13082 25 ± ± NNP cord-005453-4057qib7 13082 26 10 10 CD cord-005453-4057qib7 13082 27 % % NN cord-005453-4057qib7 13082 28 were be VBD cord-005453-4057qib7 13082 29 achieved achieve VBN cord-005453-4057qib7 13082 30 . . . cord-005453-4057qib7 13083 1 VCNs VCNs NNP cord-005453-4057qib7 13083 2 applying apply VBG cord-005453-4057qib7 13083 3 method method NN cord-005453-4057qib7 13083 4 A a NN cord-005453-4057qib7 13083 5 and and CC cord-005453-4057qib7 13083 6 B b NN cord-005453-4057qib7 13083 7 to to IN cord-005453-4057qib7 13083 8 the the DT cord-005453-4057qib7 13083 9 same same JJ cord-005453-4057qib7 13083 10 target target NN cord-005453-4057qib7 13083 11 sample sample NN cord-005453-4057qib7 13083 12 were be VBD cord-005453-4057qib7 13083 13 compared compare VBN cord-005453-4057qib7 13083 14 . . . cord-005453-4057qib7 13084 1 SP SP NNP cord-005453-4057qib7 13084 2 - - HYPH cord-005453-4057qib7 13084 3 CAR car NN cord-005453-4057qib7 13084 4 PCR PCR NNP cord-005453-4057qib7 13084 5 reaction reaction NN cord-005453-4057qib7 13084 6 displayed display VBD cord-005453-4057qib7 13084 7 efficiency efficiency NN cord-005453-4057qib7 13084 8 of of IN cord-005453-4057qib7 13084 9 103.5 103.5 CD cord-005453-4057qib7 13084 10 ± ± CD cord-005453-4057qib7 13084 11 7.1 7.1 CD cord-005453-4057qib7 13084 12 % % NN cord-005453-4057qib7 13084 13 ; ; : cord-005453-4057qib7 13084 14 104.2 104.2 CD cord-005453-4057qib7 13084 15 % % NN cord-005453-4057qib7 13084 16 ± ± NNP cord-005453-4057qib7 13084 17 2.1 2.1 CD cord-005453-4057qib7 13084 18 % % NN cord-005453-4057qib7 13084 19 and and CC cord-005453-4057qib7 13084 20 99.3 99.3 CD cord-005453-4057qib7 13084 21 ± ± XX cord-005453-4057qib7 13085 1 1.6 1.6 CD cord-005453-4057qib7 13085 2 % % NN cord-005453-4057qib7 13085 3 efficiencies efficiency NNS cord-005453-4057qib7 13085 4 were be VBD cord-005453-4057qib7 13085 5 achieved achieve VBN cord-005453-4057qib7 13085 6 for for IN cord-005453-4057qib7 13085 7 DP dp NN cord-005453-4057qib7 13085 8 - - HYPH cord-005453-4057qib7 13085 9 CAR car NN cord-005453-4057qib7 13085 10 and and CC cord-005453-4057qib7 13085 11 DP dp NN cord-005453-4057qib7 13085 12 - - HYPH cord-005453-4057qib7 13085 13 RNAse rnase RP cord-005453-4057qib7 13085 14 PCR PCR NNP cord-005453-4057qib7 13085 15 reaction reaction NN cord-005453-4057qib7 13085 16 , , , cord-005453-4057qib7 13085 17 respectively respectively RB cord-005453-4057qib7 13085 18 ( ( -LRB- cord-005453-4057qib7 13085 19 Table table NN cord-005453-4057qib7 13085 20 1 1 CD cord-005453-4057qib7 13085 21 ) ) -RRB- cord-005453-4057qib7 13085 22 . . . cord-005453-4057qib7 13086 1 Applying apply VBG cord-005453-4057qib7 13086 2 SCG SCG NNP cord-005453-4057qib7 13086 3 - - HYPH cord-005453-4057qib7 13086 4 DP DP NNP cord-005453-4057qib7 13086 5 - - HYPH cord-005453-4057qib7 13086 6 PCR pcr NN cord-005453-4057qib7 13086 7 using use VBG cord-005453-4057qib7 13086 8 formula formula NN cord-005453-4057qib7 13086 9 for for IN cord-005453-4057qib7 13086 10 relative relative JJ cord-005453-4057qib7 13086 11 CN CN NNP cord-005453-4057qib7 13086 12 assessment assessment NN cord-005453-4057qib7 13086 13 ( ( -LRB- cord-005453-4057qib7 13086 14 2 2 CD cord-005453-4057qib7 13086 15 -ΔCt -δct NN cord-005453-4057qib7 13086 16 ( ( -LRB- cord-005453-4057qib7 13086 17 DP dp NN cord-005453-4057qib7 13086 18 - - HYPH cord-005453-4057qib7 13086 19 CAR car NN cord-005453-4057qib7 13086 20 -DP -DP NNS cord-005453-4057qib7 13086 21 - - : cord-005453-4057qib7 13086 22 RNAseP RNAseP NNP cord-005453-4057qib7 13086 23 ) ) -RRB- cord-005453-4057qib7 13086 24 ) ) -RRB- cord-005453-4057qib7 13086 25 on on IN cord-005453-4057qib7 13086 26 HD hd NN cord-005453-4057qib7 13086 27 samples sample NNS cord-005453-4057qib7 13086 28 resulted result VBD cord-005453-4057qib7 13086 29 in in IN cord-005453-4057qib7 13086 30 an an DT cord-005453-4057qib7 13086 31 average average NN cord-005453-4057qib7 13086 32 of of IN cord-005453-4057qib7 13086 33 0.8 0.8 CD cord-005453-4057qib7 13086 34 ± ± CD cord-005453-4057qib7 13086 35 0.2 0.2 CD cord-005453-4057qib7 13086 36 increased increase VBD cord-005453-4057qib7 13086 37 CN cn NN cord-005453-4057qib7 13086 38 when when WRB cord-005453-4057qib7 13086 39 compared compare VBN cord-005453-4057qib7 13086 40 to to TO cord-005453-4057qib7 13086 41 method method VB cord-005453-4057qib7 13086 42 A a DT cord-005453-4057qib7 13086 43 ( ( -LRB- cord-005453-4057qib7 13086 44 Table table NN cord-005453-4057qib7 13086 45 2 2 CD cord-005453-4057qib7 13086 46 ) ) -RRB- cord-005453-4057qib7 13086 47 . . . cord-005453-4057qib7 13087 1 Conclusions conclusion NNS cord-005453-4057qib7 13087 2 : : : cord-005453-4057qib7 13088 1 In in IN cord-005453-4057qib7 13088 2 terms term NNS cord-005453-4057qib7 13088 3 of of IN cord-005453-4057qib7 13088 4 efficiency efficiency NN cord-005453-4057qib7 13088 5 and and CC cord-005453-4057qib7 13088 6 linearity linearity NN cord-005453-4057qib7 13088 7 by by IN cord-005453-4057qib7 13088 8 linear linear JJ cord-005453-4057qib7 13088 9 regression regression NN cord-005453-4057qib7 13088 10 qPCR qpcr NN cord-005453-4057qib7 13088 11 reactions reaction NNS cord-005453-4057qib7 13088 12 were be VBD cord-005453-4057qib7 13088 13 comparable comparable JJ cord-005453-4057qib7 13088 14 . . . cord-005453-4057qib7 13089 1 Validation validation NN cord-005453-4057qib7 13089 2 of of IN cord-005453-4057qib7 13089 3 SCG SCG NNP cord-005453-4057qib7 13089 4 - - HYPH cord-005453-4057qib7 13089 5 DP DP NNP cord-005453-4057qib7 13089 6 - - HYPH cord-005453-4057qib7 13089 7 PCR PCR NNP cord-005453-4057qib7 13089 8 was be VBD cord-005453-4057qib7 13089 9 achieved achieve VBN cord-005453-4057qib7 13089 10 and and CC cord-005453-4057qib7 13089 11 represents represent VBZ cord-005453-4057qib7 13089 12 an an DT cord-005453-4057qib7 13089 13 exact exact JJ cord-005453-4057qib7 13089 14 and and CC cord-005453-4057qib7 13089 15 less less RBR cord-005453-4057qib7 13089 16 error error NN cord-005453-4057qib7 13089 17 - - HYPH cord-005453-4057qib7 13089 18 prone prone JJ cord-005453-4057qib7 13089 19 method method NN cord-005453-4057qib7 13089 20 to to TO cord-005453-4057qib7 13089 21 fulfil fulfil VB cord-005453-4057qib7 13089 22 regulatory regulatory JJ cord-005453-4057qib7 13089 23 safety safety NN cord-005453-4057qib7 13089 24 release release NN cord-005453-4057qib7 13089 25 criteria criterion NNS cord-005453-4057qib7 13089 26 of of IN cord-005453-4057qib7 13089 27 CART cart NN cord-005453-4057qib7 13089 28 products product NNS cord-005453-4057qib7 13089 29 . . . cord-005453-4057qib7 13090 1 Besides besides RB cord-005453-4057qib7 13090 2 of of IN cord-005453-4057qib7 13090 3 accurately accurately RB cord-005453-4057qib7 13090 4 assessing assess VBG cord-005453-4057qib7 13090 5 VCN VCN NNP cord-005453-4057qib7 13090 6 of of IN cord-005453-4057qib7 13090 7 transduced transduce VBN cord-005453-4057qib7 13090 8 cells cell NNS cord-005453-4057qib7 13090 9 , , , cord-005453-4057qib7 13090 10 SCG SCG NNP cord-005453-4057qib7 13090 11 - - HYPH cord-005453-4057qib7 13090 12 DP DP NNP cord-005453-4057qib7 13090 13 - - HYPH cord-005453-4057qib7 13090 14 PCR PCR NNP cord-005453-4057qib7 13090 15 is be VBZ cord-005453-4057qib7 13090 16 also also RB cord-005453-4057qib7 13090 17 a a DT cord-005453-4057qib7 13090 18 highly highly RB cord-005453-4057qib7 13090 19 robust robust JJ cord-005453-4057qib7 13090 20 method method NN cord-005453-4057qib7 13090 21 to to TO cord-005453-4057qib7 13090 22 follow follow VB cord-005453-4057qib7 13090 23 - - HYPH cord-005453-4057qib7 13090 24 up up RP cord-005453-4057qib7 13090 25 CARTs cart NNS cord-005453-4057qib7 13090 26 in in IN cord-005453-4057qib7 13090 27 treated treat VBN cord-005453-4057qib7 13090 28 patients patient NNS cord-005453-4057qib7 13090 29 . . . cord-005453-4057qib7 13091 1 Applying apply VBG cord-005453-4057qib7 13091 2 this this DT cord-005453-4057qib7 13091 3 approach approach NN cord-005453-4057qib7 13091 4 , , , cord-005453-4057qib7 13091 5 no no DT cord-005453-4057qib7 13091 6 standard standard JJ cord-005453-4057qib7 13091 7 curve curve NN cord-005453-4057qib7 13091 8 is be VBZ cord-005453-4057qib7 13091 9 needed need VBN cord-005453-4057qib7 13091 10 , , , cord-005453-4057qib7 13091 11 hence hence RB cord-005453-4057qib7 13091 12 significantly significantly RB cord-005453-4057qib7 13091 13 economizing economize VBG cord-005453-4057qib7 13091 14 required require VBN cord-005453-4057qib7 13091 15 material material NN cord-005453-4057qib7 13091 16 as as RB cord-005453-4057qib7 13091 17 well well RB cord-005453-4057qib7 13091 18 as as IN cord-005453-4057qib7 13091 19 time time NN cord-005453-4057qib7 13091 20 . . . cord-005453-4057qib7 13092 1 Disclosure disclosure NN cord-005453-4057qib7 13092 2 : : : cord-005453-4057qib7 13092 3 Nothing nothing NN cord-005453-4057qib7 13092 4 to to TO cord-005453-4057qib7 13092 5 declare declare VB cord-005453-4057qib7 13092 6 Background background NN cord-005453-4057qib7 13092 7 : : : cord-005453-4057qib7 13092 8 T T NNP cord-005453-4057qib7 13092 9 - - HYPH cord-005453-4057qib7 13092 10 cells cell NNS cord-005453-4057qib7 13092 11 ' ' POS cord-005453-4057qib7 13092 12 antileukemic antileukemic JJ cord-005453-4057qib7 13092 13 responses response NNS cord-005453-4057qib7 13092 14 in in IN cord-005453-4057qib7 13092 15 AML AML NNP cord-005453-4057qib7 13092 16 - - HYPH cord-005453-4057qib7 13092 17 pts pts NN cord-005453-4057qib7 13092 18 need need NN cord-005453-4057qib7 13092 19 to to TO cord-005453-4057qib7 13092 20 be be VB cord-005453-4057qib7 13092 21 improved improve VBN cord-005453-4057qib7 13092 22 . . . cord-005453-4057qib7 13093 1 DC DC NNP cord-005453-4057qib7 13093 2 leu leu NNP cord-005453-4057qib7 13093 3 effectively effectively RB cord-005453-4057qib7 13093 4 activate activate VBP cord-005453-4057qib7 13093 5 T T NNP cord-005453-4057qib7 13093 6 - - HYPH cord-005453-4057qib7 13093 7 cells cell NNS cord-005453-4057qib7 13093 8 against against IN cord-005453-4057qib7 13093 9 leukemic leukemic JJ cord-005453-4057qib7 13093 10 blasts blast NNS cord-005453-4057qib7 13093 11 , , , cord-005453-4057qib7 13093 12 resulting result VBG cord-005453-4057qib7 13093 13 in in IN cord-005453-4057qib7 13093 14 blast blast NN cord-005453-4057qib7 13093 15 - - HYPH cord-005453-4057qib7 13093 16 lysis lysis NN cord-005453-4057qib7 13093 17 ex ex NN cord-005453-4057qib7 13093 18 - - NN cord-005453-4057qib7 13093 19 vivo vivo NN cord-005453-4057qib7 13093 20 . . . cord-005453-4057qib7 13094 1 Factors factor NNS cord-005453-4057qib7 13094 2 influencing influence VBG cord-005453-4057qib7 13094 3 these these DT cord-005453-4057qib7 13094 4 activities activity NNS cord-005453-4057qib7 13094 5 are be VBP cord-005453-4057qib7 13094 6 not not RB cord-005453-4057qib7 13094 7 known know VBN cord-005453-4057qib7 13094 8 . . . cord-005453-4057qib7 13095 1 Methods method NNS cord-005453-4057qib7 13095 2 : : : cord-005453-4057qib7 13095 3 We -PRON- PRP cord-005453-4057qib7 13095 4 generated generate VBD cord-005453-4057qib7 13095 5 DC DC NNP cord-005453-4057qib7 13095 6 / / SYM cord-005453-4057qib7 13095 7 DC DC NNP cord-005453-4057qib7 13095 8 leu leu NNP cord-005453-4057qib7 13095 9 from from IN cord-005453-4057qib7 13095 10 AML AML NNP cord-005453-4057qib7 13095 11 - - HYPH cord-005453-4057qib7 13095 12 blastcontaining blastcontaine VBG cord-005453-4057qib7 13095 13 mononuclear mononuclear NN cord-005453-4057qib7 13095 14 cells cell NNS cord-005453-4057qib7 13095 15 ( ( -LRB- cord-005453-4057qib7 13095 16 n=74 n=74 NNP cord-005453-4057qib7 13095 17 ) ) -RRB- cord-005453-4057qib7 13095 18 using use VBG cord-005453-4057qib7 13095 19 standard standard JJ cord-005453-4057qib7 13095 20 methods method NNS cord-005453-4057qib7 13095 21 ( ( -LRB- cord-005453-4057qib7 13095 22 MCM MCM NNP cord-005453-4057qib7 13095 23 - - HYPH cord-005453-4057qib7 13095 24 Mimic Mimic NNP cord-005453-4057qib7 13095 25 / / SYM cord-005453-4057qib7 13095 26 Ca Ca NNP cord-005453-4057qib7 13095 27 - - HYPH cord-005453-4057qib7 13095 28 Ionophore Ionophore NNP cord-005453-4057qib7 13095 29 / / SYM cord-005453-4057qib7 13095 30 Picibanil Picibanil NNP cord-005453-4057qib7 13095 31 / / SYM cord-005453-4057qib7 13095 32 IFN IFN NNP cord-005453-4057qib7 13095 33 - - HYPH cord-005453-4057qib7 13095 34 α α NNP cord-005453-4057qib7 13095 35 , , , cord-005453-4057qib7 13095 36 " " `` cord-005453-4057qib7 13095 37 MNC mnc NN cord-005453-4057qib7 13095 38 - - HYPH cord-005453-4057qib7 13095 39 methods method NNS cord-005453-4057qib7 13095 40 " " '' cord-005453-4057qib7 13095 41 ) ) -RRB- cord-005453-4057qib7 13095 42 and and CC cord-005453-4057qib7 13095 43 from from IN cord-005453-4057qib7 13095 44 blast blast NN cord-005453-4057qib7 13095 45 - - HYPH cord-005453-4057qib7 13095 46 containing contain VBG cord-005453-4057qib7 13095 47 heparinized heparinize VBN cord-005453-4057qib7 13095 48 whole whole JJ cord-005453-4057qib7 13095 49 blood blood NN cord-005453-4057qib7 13095 50 ( ( -LRB- cord-005453-4057qib7 13095 51 n=35 n=35 NN cord-005453-4057qib7 13095 52 ) ) -RRB- cord-005453-4057qib7 13095 53 using use VBG cord-005453-4057qib7 13095 54 modulatory modulatory JJ cord-005453-4057qib7 13095 55 kits kit NNS cord-005453-4057qib7 13095 56 ( ( -LRB- cord-005453-4057qib7 13095 57 various various JJ cord-005453-4057qib7 13095 58 combinations combination NNS cord-005453-4057qib7 13095 59 of of IN cord-005453-4057qib7 13095 60 2 2 CD cord-005453-4057qib7 13095 61 - - SYM cord-005453-4057qib7 13095 62 3 3 CD cord-005453-4057qib7 13095 63 clinically clinically RB cord-005453-4057qib7 13095 64 approved approve VBN cord-005453-4057qib7 13095 65 response response NN cord-005453-4057qib7 13095 66 - - HYPH cord-005453-4057qib7 13095 67 modifiers modifier NNS cord-005453-4057qib7 13095 68 , , , cord-005453-4057qib7 13095 69 " " '' cord-005453-4057qib7 13095 70 WB WB NNP cord-005453-4057qib7 13095 71 - - HYPH cord-005453-4057qib7 13095 72 kits kit NNS cord-005453-4057qib7 13095 73 " " '' cord-005453-4057qib7 13095 74 , , , cord-005453-4057qib7 13095 75 patent patent NN cord-005453-4057qib7 13095 76 102014014993 102014014993 CD cord-005453-4057qib7 13095 77 ) ) -RRB- cord-005453-4057qib7 13095 78 and and CC cord-005453-4057qib7 13095 79 correlated correlate VBN cord-005453-4057qib7 13095 80 statistically statistically RB cord-005453-4057qib7 13095 81 ( ( -LRB- cord-005453-4057qib7 13095 82 T-/U t-/u JJ cord-005453-4057qib7 13095 83 - - HYPH cord-005453-4057qib7 13095 84 test test NN cord-005453-4057qib7 13095 85 , , , cord-005453-4057qib7 13095 86 Pearsons Pearsons NNP cord-005453-4057qib7 13095 87 correlation correlation NN cord-005453-4057qib7 13095 88 , , , cord-005453-4057qib7 13095 89 # # NN cord-005453-4057qib7 13095 90 means mean VBZ cord-005453-4057qib7 13095 91 significant significant JJ cord-005453-4057qib7 13095 92 ) ) -RRB- cord-005453-4057qib7 13095 93 proportions proportion NNS cord-005453-4057qib7 13095 94 of of IN cord-005453-4057qib7 13095 95 DC-/T dc-/t JJ cord-005453-4057qib7 13095 96 - - HYPH cord-005453-4057qib7 13095 97 cell cell NN cord-005453-4057qib7 13095 98 - - HYPH cord-005453-4057qib7 13095 99 subtypes subtype NNS cord-005453-4057qib7 13095 100 / / SYM cord-005453-4057qib7 13095 101 cytokine cytokine NN cord-005453-4057qib7 13095 102 - - HYPH cord-005453-4057qib7 13095 103 profiles profile NNS cord-005453-4057qib7 13095 104 with with IN cord-005453-4057qib7 13095 105 T T NNP cord-005453-4057qib7 13095 106 - - HYPH cord-005453-4057qib7 13095 107 cells cell NNS cord-005453-4057qib7 13095 108 ' ' POS cord-005453-4057qib7 13095 109 antileukemic antileukemic NN cord-005453-4057qib7 13095 110 cytotoxicity cytotoxicity NN cord-005453-4057qib7 13095 111 ( ( -LRB- cord-005453-4057qib7 13095 112 CTX CTX NNP cord-005453-4057qib7 13095 113 ) ) -RRB- cord-005453-4057qib7 13095 114 , , , cord-005453-4057qib7 13095 115 achieved achieve VBN cord-005453-4057qib7 13095 116 after after IN cord-005453-4057qib7 13095 117 mixed mixed JJ cord-005453-4057qib7 13095 118 lymphocyte lymphocyte NN cord-005453-4057qib7 13095 119 culture culture NN cord-005453-4057qib7 13095 120 ( ( -LRB- cord-005453-4057qib7 13095 121 MLC MLC NNP cord-005453-4057qib7 13095 122 ) ) -RRB- cord-005453-4057qib7 13095 123 with with IN cord-005453-4057qib7 13095 124 / / SYM cord-005453-4057qib7 13095 125 without without IN cord-005453-4057qib7 13095 126 MNCmethod-("T*DC MNCmethod-("T*DC NNP cord-005453-4057qib7 13095 127 MNC MNC NNP cord-005453-4057qib7 13095 128 " " '' cord-005453-4057qib7 13095 129 /"T*Bla /"T*Bla . cord-005453-4057qib7 13096 1 MNC MNC NNP cord-005453-4057qib7 13096 2 ") ") '' cord-005453-4057qib7 13096 3 or or CC cord-005453-4057qib7 13096 4 WB WB NNP cord-005453-4057qib7 13096 5 - - HYPH cord-005453-4057qib7 13096 6 kit kit NN cord-005453-4057qib7 13096 7 - - HYPH cord-005453-4057qib7 13096 8 treated treat VBN cord-005453-4057qib7 13096 9 cultures culture NNS cord-005453-4057qib7 13096 10 ( ( -LRB- cord-005453-4057qib7 13096 11 " " `` cord-005453-4057qib7 13096 12 T*DC T*DC NNP cord-005453-4057qib7 13096 13 WB WB NNP cord-005453-4057qib7 13096 14 " " '' cord-005453-4057qib7 13096 15 /T*Bla /T*Bla . cord-005453-4057qib7 13097 1 WB WB NNP cord-005453-4057qib7 13097 2 ") ") '' cord-005453-4057qib7 13097 3 . . . cord-005453-4057qib7 13098 1 CTX CTX NNP cord-005453-4057qib7 13098 2 was be VBD cord-005453-4057qib7 13098 3 given give VBN cord-005453-4057qib7 13098 4 as as IN cord-005453-4057qib7 13098 5 proportions proportion NNS cord-005453-4057qib7 13098 6 of of IN cord-005453-4057qib7 13098 7 cases case NNS cord-005453-4057qib7 13098 8 with with IN cord-005453-4057qib7 13098 9 achieved achieve VBN cord-005453-4057qib7 13098 10 or or CC cord-005453-4057qib7 13098 11 " " `` cord-005453-4057qib7 13098 12 improved improve VBN cord-005453-4057qib7 13098 13 " " '' cord-005453-4057qib7 13098 14 blast blast NN cord-005453-4057qib7 13098 15 - - HYPH cord-005453-4057qib7 13098 16 lysis lysis NN cord-005453-4057qib7 13098 17 compared compare VBN cord-005453-4057qib7 13098 18 to to TO cord-005453-4057qib7 13098 19 control control NN cord-005453-4057qib7 13098 20 and and CC cord-005453-4057qib7 13098 21 as as IN cord-005453-4057qib7 13098 22 frequencies frequency NNS cord-005453-4057qib7 13098 23 of of IN cord-005453-4057qib7 13098 24 viable viable JJ cord-005453-4057qib7 13098 25 blasts blast NNS cord-005453-4057qib7 13098 26 ( ( -LRB- cord-005453-4057qib7 13098 27 bla bla NNP cord-005453-4057qib7 13098 28 via via IN cord-005453-4057qib7 13098 29 ) ) -RRB- cord-005453-4057qib7 13099 1 after after IN cord-005453-4057qib7 13099 2 effector effector NN cord-005453-4057qib7 13099 3 - - HYPH cord-005453-4057qib7 13099 4 cell cell NN cord-005453-4057qib7 13099 5 - - HYPH cord-005453-4057qib7 13099 6 influence influence NN cord-005453-4057qib7 13099 7 . . . cord-005453-4057qib7 13100 1 Pooled pool VBN cord-005453-4057qib7 13100 2 data datum NNS cord-005453-4057qib7 13100 3 and and CC cord-005453-4057qib7 13100 4 data datum NNS cord-005453-4057qib7 13100 5 obtained obtain VBN cord-005453-4057qib7 13100 6 with with IN cord-005453-4057qib7 13100 7 single single JJ cord-005453-4057qib7 13100 8 methods method NNS cord-005453-4057qib7 13100 9 in in IN cord-005453-4057qib7 13100 10 different different JJ cord-005453-4057qib7 13100 11 cohorts cohort NNS cord-005453-4057qib7 13100 12 are be VBP cord-005453-4057qib7 13100 13 given give VBN cord-005453-4057qib7 13100 14 . . . cord-005453-4057qib7 13101 1 Results result NNS cord-005453-4057qib7 13101 2 : : : cord-005453-4057qib7 13101 3 1 1 CD cord-005453-4057qib7 13101 4 . . . cord-005453-4057qib7 13102 1 Generation generation NN cord-005453-4057qib7 13102 2 of of IN cord-005453-4057qib7 13102 3 DC DC NNP cord-005453-4057qib7 13102 4 / / SYM cord-005453-4057qib7 13102 5 DC DC NNP cord-005453-4057qib7 13102 6 leu leu NNP cord-005453-4057qib7 13102 7 : : : cord-005453-4057qib7 13102 8 with with IN cord-005453-4057qib7 13102 9 a a DT cord-005453-4057qib7 13102 10 ) ) -RRB- cord-005453-4057qib7 13102 11 MNCmethods MNCmethods NNP cord-005453-4057qib7 13102 12 : : : cord-005453-4057qib7 13103 1 Ø18±15 ø18±15 RB cord-005453-4057qib7 13103 2 % % NN cord-005453-4057qib7 13103 3 DC DC NNP cord-005453-4057qib7 13103 4 and and CC cord-005453-4057qib7 13103 5 Ø11±10 ø11±10 NN cord-005453-4057qib7 13103 6 % % NN cord-005453-4057qib7 13103 7 DC DC NNP cord-005453-4057qib7 13103 8 leu leu NNP cord-005453-4057qib7 13103 9 and and CC cord-005453-4057qib7 13103 10 b b LS cord-005453-4057qib7 13103 11 ) ) -RRB- cord-005453-4057qib7 13103 12 WB WB NNP cord-005453-4057qib7 13103 13 - - HYPH cord-005453-4057qib7 13103 14 kits kit NNS cord-005453-4057qib7 13103 15 : : : cord-005453-4057qib7 13103 16 Ø13±8 ø13±8 JJ cord-005453-4057qib7 13103 17 % % NN cord-005453-4057qib7 13103 18 DC DC NNP cord-005453-4057qib7 13103 19 and and CC cord-005453-4057qib7 13103 20 Ø11±13 ø11±13 NN cord-005453-4057qib7 13103 21 % % NN cord-005453-4057qib7 13103 22 DC DC NNP cord-005453-4057qib7 13103 23 leu leu NNP cord-005453-4057qib7 13103 24 without without IN cord-005453-4057qib7 13103 25 induction induction NN cord-005453-4057qib7 13103 26 of of IN cord-005453-4057qib7 13103 27 blasts blast NNS cord-005453-4057qib7 13103 28 ' ' POS cord-005453-4057qib7 13103 29 proliferation proliferation NN cord-005453-4057qib7 13103 30 . . . cord-005453-4057qib7 13104 1 T t NN cord-005453-4057qib7 13104 2 - - HYPH cord-005453-4057qib7 13104 3 cell cell NN cord-005453-4057qib7 13104 4 - - HYPH cord-005453-4057qib7 13104 5 proliferation proliferation NN cord-005453-4057qib7 13104 6 increased increase VBN cord-005453-4057qib7 13104 7 ( ( -LRB- cord-005453-4057qib7 13104 8 vs vs IN cord-005453-4057qib7 13104 9 uncultured uncultured JJ cord-005453-4057qib7 13104 10 T T NNP cord-005453-4057qib7 13104 11 - - HYPH cord-005453-4057qib7 13104 12 cells cell NNS cord-005453-4057qib7 13104 13 ) ) -RRB- cord-005453-4057qib7 13104 14 after after IN cord-005453-4057qib7 13104 15 MLC MLC NNP cord-005453-4057qib7 13104 16 with with IN cord-005453-4057qib7 13104 17 a a DT cord-005453-4057qib7 13104 18 ) ) -RRB- cord-005453-4057qib7 13104 19 MNC MNC NNP cord-005453-4057qib7 13104 20 - - HYPH cord-005453-4057qib7 13104 21 methods method NNS cord-005453-4057qib7 13104 22 : : : cord-005453-4057qib7 13104 23 Ø34±38 ø34±38 JJ cord-005453-4057qib7 13104 24 % % NN cord-005453-4057qib7 13104 25 vs vs IN cord-005453-4057qib7 13104 26 Ø7±9 Ø7±9 NNP cord-005453-4057qib7 13104 27 % % NN cord-005453-4057qib7 13104 28 and and CC cord-005453-4057qib7 13104 29 b b LS cord-005453-4057qib7 13104 30 ) ) -RRB- cord-005453-4057qib7 13104 31 WB WB NNP cord-005453-4057qib7 13104 32 - - HYPH cord-005453-4057qib7 13104 33 kits kit NNS cord-005453-4057qib7 13104 34 : : : cord-005453-4057qib7 13105 1 Ø63±25 Ø63±25 NNP cord-005453-4057qib7 13105 2 % % NN cord-005453-4057qib7 13105 3 vs vs IN cord-005453-4057qib7 13105 4 Ø23±20 ø23±20 JJ cord-005453-4057qib7 13105 5 % % NN cord-005453-4057qib7 13105 6 . . . cord-005453-4057qib7 13106 1 2 2 LS cord-005453-4057qib7 13106 2 . . . cord-005453-4057qib7 13107 1 Antileukemic Antileukemic NNP cord-005453-4057qib7 13107 2 reactivity reactivity NN cord-005453-4057qib7 13107 3 ( ( -LRB- cord-005453-4057qib7 13107 4 T t NN cord-005453-4057qib7 13107 5 - - HYPH cord-005453-4057qib7 13107 6 effector effector NN cord-005453-4057qib7 13107 7 - - HYPH cord-005453-4057qib7 13107 8 cell cell NN cord-005453-4057qib7 13107 9 - - HYPH cord-005453-4057qib7 13107 10 cytotoxicity cytotoxicity NN cord-005453-4057qib7 13107 11 after after IN cord-005453-4057qib7 13107 12 MLC MLC NNP cord-005453-4057qib7 13107 13 ) ) -RRB- cord-005453-4057qib7 13107 14 : : : cord-005453-4057qib7 13108 1 Pooling pool VBG cord-005453-4057qib7 13108 2 all all DT cord-005453-4057qib7 13108 3 data datum NNS cord-005453-4057qib7 13108 4 : : : cord-005453-4057qib7 13108 5 a a LS cord-005453-4057qib7 13108 6 ) ) -RRB- cord-005453-4057qib7 13108 7 MNC MNC NNP cord-005453-4057qib7 13108 8 - - HYPH cord-005453-4057qib7 13108 9 methods method NNS cord-005453-4057qib7 13108 10 ( ( -LRB- cord-005453-4057qib7 13108 11 " " `` cord-005453-4057qib7 13108 12 T*DC T*DC NNP cord-005453-4057qib7 13108 13 MNC MNC NNP cord-005453-4057qib7 13108 14 " " '' cord-005453-4057qib7 13108 15 vs vs IN cord-005453-4057qib7 13108 16 " " `` cord-005453-4057qib7 13108 17 T*Bla t*bla JJ cord-005453-4057qib7 13108 18 MNC MNC NNP cord-005453-4057qib7 13108 19 " " '' cord-005453-4057qib7 13109 1 ): ): NNP cord-005453-4057qib7 13110 1 we -PRON- PRP cord-005453-4057qib7 13110 2 found find VBD cord-005453-4057qib7 13110 3 a1 a1 NNP cord-005453-4057qib7 13110 4 ) ) -RRB- cord-005453-4057qib7 13111 1 blast blast NN cord-005453-4057qib7 13111 2 - - HYPH cord-005453-4057qib7 13111 3 cytotoxicity cytotoxicity NN cord-005453-4057qib7 13111 4 in in IN cord-005453-4057qib7 13111 5 Ø70%(vs50 ø70%(vs50 CD cord-005453-4057qib7 13111 6 % % NN cord-005453-4057qib7 13111 7 ) ) -RRB- cord-005453-4057qib7 13111 8 of of IN cord-005453-4057qib7 13111 9 cases case NNS cord-005453-4057qib7 13111 10 with with IN cord-005453-4057qib7 13111 11 Ø59%(vs117 Ø59%(vs117 NNP cord-005453-4057qib7 13111 12 % % NN cord-005453-4057qib7 13111 13 ) ) -RRB- cord-005453-4057qib7 13112 1 bla bla NNP cord-005453-4057qib7 13113 1 via via IN cord-005453-4057qib7 13113 2 , , , cord-005453-4057qib7 13113 3 a2 a2 NNP cord-005453-4057qib7 13113 4 ) ) -RRB- cord-005453-4057qib7 13114 1 blast blast NN cord-005453-4057qib7 13114 2 - - HYPH cord-005453-4057qib7 13114 3 cytotoxicity cytotoxicity NN cord-005453-4057qib7 13114 4 was be VBD cord-005453-4057qib7 13114 5 improved improve VBN cord-005453-4057qib7 13114 6 ( ( -LRB- cord-005453-4057qib7 13114 7 vs vs IN cord-005453-4057qib7 13114 8 control control NN cord-005453-4057qib7 13114 9 ) ) -RRB- cord-005453-4057qib7 13114 10 in in IN cord-005453-4057qib7 13114 11 86 86 CD cord-005453-4057qib7 13114 12 % % NN cord-005453-4057qib7 13114 13 with with IN cord-005453-4057qib7 13114 14 Ø Ø NNP cord-005453-4057qib7 13114 15 decrease decrease NN cord-005453-4057qib7 13114 16 of of IN cord-005453-4057qib7 13114 17 bla bla NN cord-005453-4057qib7 13114 18 via via IN cord-005453-4057qib7 13114 19 of of IN cord-005453-4057qib7 13114 20 78 78 CD cord-005453-4057qib7 13114 21 % % NN cord-005453-4057qib7 13114 22 ; ; : cord-005453-4057qib7 13114 23 b b LS cord-005453-4057qib7 13114 24 ) ) -RRB- cord-005453-4057qib7 13114 25 WB WB NNP cord-005453-4057qib7 13114 26 - - HYPH cord-005453-4057qib7 13114 27 kits kit NNS cord-005453-4057qib7 13114 28 ( ( -LRB- cord-005453-4057qib7 13114 29 " " `` cord-005453-4057qib7 13114 30 T*DC T*DC NNP cord-005453-4057qib7 13114 31 WB WB NNP cord-005453-4057qib7 13114 32 " " '' cord-005453-4057qib7 13114 33 vs vs IN cord-005453-4057qib7 13114 34 " " `` cord-005453-4057qib7 13114 35 T*Bla t*bla JJ cord-005453-4057qib7 13114 36 WB WB NNP cord-005453-4057qib7 13114 37 " " '' cord-005453-4057qib7 13115 1 ): ): NNP cord-005453-4057qib7 13116 1 we -PRON- PRP cord-005453-4057qib7 13116 2 found find VBD cord-005453-4057qib7 13116 3 b1 b1 NN cord-005453-4057qib7 13116 4 ) ) -RRB- cord-005453-4057qib7 13116 5 blastcytotoxicity blastcytotoxicity NN cord-005453-4057qib7 13116 6 in in IN cord-005453-4057qib7 13116 7 Ø80%(vs71 ø80%(vs71 CD cord-005453-4057qib7 13116 8 % % NN cord-005453-4057qib7 13116 9 ) ) -RRB- cord-005453-4057qib7 13116 10 of of IN cord-005453-4057qib7 13116 11 cases case NNS cord-005453-4057qib7 13116 12 with with IN cord-005453-4057qib7 13116 13 Ø68%(vs56 ø68%(vs56 CD cord-005453-4057qib7 13116 14 % % NN cord-005453-4057qib7 13116 15 ) ) -RRB- cord-005453-4057qib7 13117 1 bla bla NNP cord-005453-4057qib7 13118 1 via via IN cord-005453-4057qib7 13118 2 , , , cord-005453-4057qib7 13118 3 b2 b2 NN cord-005453-4057qib7 13118 4 ) ) -RRB- cord-005453-4057qib7 13119 1 blast blast NN cord-005453-4057qib7 13119 2 - - HYPH cord-005453-4057qib7 13119 3 cytotoxicity cytotoxicity NN cord-005453-4057qib7 13119 4 was be VBD cord-005453-4057qib7 13119 5 improved improve VBN cord-005453-4057qib7 13119 6 ( ( -LRB- cord-005453-4057qib7 13119 7 vs vs IN cord-005453-4057qib7 13119 8 control control NN cord-005453-4057qib7 13119 9 ) ) -RRB- cord-005453-4057qib7 13119 10 in in IN cord-005453-4057qib7 13119 11 67 67 CD cord-005453-4057qib7 13119 12 % % NN cord-005453-4057qib7 13119 13 of of IN cord-005453-4057qib7 13119 14 cases case NNS cord-005453-4057qib7 13119 15 with with IN cord-005453-4057qib7 13119 16 Ø Ø NNP cord-005453-4057qib7 13119 17 decrease decrease NN cord-005453-4057qib7 13119 18 of of IN cord-005453-4057qib7 13119 19 bla bla NN cord-005453-4057qib7 13119 20 via via IN cord-005453-4057qib7 13119 21 of of IN cord-005453-4057qib7 13119 22 43 43 CD cord-005453-4057qib7 13119 23 % % NN cord-005453-4057qib7 13119 24 . . . cord-005453-4057qib7 13120 1 In in IN cord-005453-4057qib7 13120 2 general general JJ cord-005453-4057qib7 13120 3 , , , cord-005453-4057qib7 13120 4 these these DT cord-005453-4057qib7 13120 5 results result NNS cord-005453-4057qib7 13120 6 could could MD cord-005453-4057qib7 13120 7 be be VB cord-005453-4057qib7 13120 8 confirmed confirm VBN cord-005453-4057qib7 13120 9 with with IN cord-005453-4057qib7 13120 10 single single JJ cord-005453-4057qib7 13120 11 methods method NNS cord-005453-4057qib7 13120 12 : : : cord-005453-4057qib7 13120 13 best good JJS cord-005453-4057qib7 13120 14 MNC MNC NNP cord-005453-4057qib7 13120 15 - - HYPH cord-005453-4057qib7 13120 16 methods method NNS cord-005453-4057qib7 13120 17 were be VBD cord-005453-4057qib7 13120 18 Picibanil Picibanil NNP cord-005453-4057qib7 13120 19 and and CC cord-005453-4057qib7 13120 20 MCM MCM NNP cord-005453-4057qib7 13120 21 - - HYPH cord-005453-4057qib7 13120 22 Mimic mimic JJ cord-005453-4057qib7 13120 23 , , , cord-005453-4057qib7 13120 24 best good JJS cord-005453-4057qib7 13120 25 WBkits wbkit NNS cord-005453-4057qib7 13120 26 were be VBD cord-005453-4057qib7 13120 27 kits kit NNS cord-005453-4057qib7 13120 28 containing contain VBG cord-005453-4057qib7 13120 29 GM GM NNP cord-005453-4057qib7 13120 30 - - , cord-005453-4057qib7 13120 31 CSF+Picibanil csf+picibanil NN cord-005453-4057qib7 13120 32 or or CC cord-005453-4057qib7 13120 33 Prostaglandins prostaglandin NNS cord-005453-4057qib7 13120 34 . . . cord-005453-4057qib7 13121 1 3 3 LS cord-005453-4057qib7 13121 2 . . . cord-005453-4057qib7 13122 1 Correlations correlation NNS cord-005453-4057qib7 13122 2 : : : cord-005453-4057qib7 13123 1 Pooling pool VBG cord-005453-4057qib7 13123 2 all all DT cord-005453-4057qib7 13123 3 data datum NNS cord-005453-4057qib7 13123 4 : : : cord-005453-4057qib7 13123 5 cases case NNS cord-005453-4057qib7 13123 6 with with IN cord-005453-4057qib7 13123 7 " " `` cord-005453-4057qib7 13123 8 improved improve VBN cord-005453-4057qib7 13123 9 " " '' cord-005453-4057qib7 13123 10 lysis lysis NN cord-005453-4057qib7 13123 11 ( ( -LRB- cord-005453-4057qib7 13123 12 vs vs IN cord-005453-4057qib7 13123 13 " " `` cord-005453-4057qib7 13123 14 not not RB cord-005453-4057qib7 13123 15 improved improve VBN cord-005453-4057qib7 13123 16 " " '' cord-005453-4057qib7 13123 17 lysis lysis NN cord-005453-4057qib7 13123 18 ) ) -RRB- cord-005453-4057qib7 13123 19 were be VBD cord-005453-4057qib7 13123 20 characterized characterize VBN cord-005453-4057qib7 13123 21 by by IN cord-005453-4057qib7 13123 22 a a DT cord-005453-4057qib7 13123 23 ) ) -RRB- cord-005453-4057qib7 13123 24 MNC MNC NNP cord-005453-4057qib7 13123 25 - - HYPH cord-005453-4057qib7 13123 26 methods method NNS cord-005453-4057qib7 13123 27 : : : cord-005453-4057qib7 13123 28 increased increase VBN cord-005453-4057qib7 13123 29 proportions proportion NNS cord-005453-4057qib7 13123 30 of of IN cord-005453-4057qib7 13123 31 mature mature JJ cord-005453-4057qib7 13123 32 DC DC NNP cord-005453-4057qib7 13123 33 / / SYM cord-005453-4057qib7 13123 34 cells cell NNS cord-005453-4057qib7 13123 35 ( ( -LRB- cord-005453-4057qib7 13123 36 Ø46±29 Ø46±29 NNP cord-005453-4057qib7 13123 37 % % NN cord-005453-4057qib7 13123 38 vs vs IN cord-005453-4057qib7 13123 39 Ø35±20 ø35±20 NN cord-005453-4057qib7 13123 40 % % NN cord-005453-4057qib7 13123 41 ) ) -RRB- cord-005453-4057qib7 13123 42 , , , cord-005453-4057qib7 13123 43 DC DC NNP cord-005453-4057qib7 13123 44 leu leu NNP cord-005453-4057qib7 13123 45 /cells /cells . cord-005453-4057qib7 13123 46 ( ( -LRB- cord-005453-4057qib7 13123 47 Ø10±10 ø10±10 NN cord-005453-4057qib7 13123 48 % % NN cord-005453-4057qib7 13123 49 vs vs IN cord-005453-4057qib7 13123 50 Ø5±4 ø5±4 CD cord-005453-4057qib7 13123 51 % % NN cord-005453-4057qib7 13123 52 ) ) -RRB- cord-005453-4057qib7 13123 53 and and CC cord-005453-4057qib7 13123 54 proliferating proliferate VBG cord-005453-4057qib7 13123 55 T t NN cord-005453-4057qib7 13123 56 - - HYPH cord-005453-4057qib7 13123 57 cells cell NNS cord-005453-4057qib7 13123 58 ( ( -LRB- cord-005453-4057qib7 13123 59 Ø35±40 ø35±40 NN cord-005453-4057qib7 13123 60 % % NN cord-005453-4057qib7 13123 61 vs vs IN cord-005453-4057qib7 13123 62 Ø19 Ø19 NNP cord-005453-4057qib7 13123 63 ±14 ±14 NNP cord-005453-4057qib7 13123 64 % % NN cord-005453-4057qib7 13123 65 ) ) -RRB- cord-005453-4057qib7 13123 66 , , , cord-005453-4057qib7 13123 67 b b LS cord-005453-4057qib7 13123 68 ) ) -RRB- cord-005453-4057qib7 13123 69 WB WB NNP cord-005453-4057qib7 13123 70 - - HYPH cord-005453-4057qib7 13123 71 methods method NNS cord-005453-4057qib7 13123 72 : : : cord-005453-4057qib7 13123 73 DC DC NNP cord-005453-4057qib7 13123 74 / / SYM cord-005453-4057qib7 13123 75 cells cell NNS cord-005453-4057qib7 13123 76 ( ( -LRB- cord-005453-4057qib7 13123 77 r=0.781 r=0.781 NNP cord-005453-4057qib7 13123 78 # # NN cord-005453-4057qib7 13123 79 ) ) -RRB- cord-005453-4057qib7 13123 80 , , , cord-005453-4057qib7 13123 81 DC DC NNP cord-005453-4057qib7 13123 82 leu leu NNP cord-005453-4057qib7 13123 83 /cells /cells . cord-005453-4057qib7 13123 84 ( ( -LRB- cord-005453-4057qib7 13123 85 r=0.815 r=0.815 NNP cord-005453-4057qib7 13123 86 # # $ cord-005453-4057qib7 13123 87 ) ) -RRB- cord-005453-4057qib7 13123 88 , , , cord-005453-4057qib7 13123 89 DC DC NNP cord-005453-4057qib7 13123 90 leu leu NNP cord-005453-4057qib7 13123 91 /bla /bla . cord-005453-4057qib7 13124 1 ( ( -LRB- cord-005453-4057qib7 13124 2 Ø40±23 Ø40±23 NNP cord-005453-4057qib7 13124 3 % % NN cord-005453-4057qib7 13124 4 vs vs IN cord-005453-4057qib7 13124 5 Ø29±16 Ø29±16 NNP cord-005453-4057qib7 13124 6 % % NN cord-005453-4057qib7 13124 7 ) ) -RRB- cord-005453-4057qib7 13124 8 , , , cord-005453-4057qib7 13124 9 DC DC NNP cord-005453-4057qib7 13124 10 leu leu NNP cord-005453-4057qib7 13124 11 /DC /DC . cord-005453-4057qib7 13125 1 ( ( -LRB- cord-005453-4057qib7 13125 2 Ø59±22 Ø59±22 NNP cord-005453-4057qib7 13125 3 % % NN cord-005453-4057qib7 13125 4 vs vs IN cord-005453-4057qib7 13125 5 Ø51±25 ø51±25 NN cord-005453-4057qib7 13125 6 % % NN cord-005453-4057qib7 13125 7 ) ) -RRB- cord-005453-4057qib7 13125 8 , , , cord-005453-4057qib7 13125 9 CD8 CD8 NNP cord-005453-4057qib7 13125 10 + + CC cord-005453-4057qib7 13125 11 T T NNP cord-005453-4057qib7 13125 12 - - HYPH cord-005453-4057qib7 13125 13 cells cell NNS cord-005453-4057qib7 13125 14 ( ( -LRB- cord-005453-4057qib7 13126 1 Ø58±20 Ø58±20 NNS cord-005453-4057qib7 13126 2 % % NN cord-005453-4057qib7 13126 3 vs vs IN cord-005453-4057qib7 13126 4 Ø50 Ø50 NNP cord-005453-4057qib7 13126 5 ±24 ±24 NNP cord-005453-4057qib7 13126 6 % % NN cord-005453-4057qib7 13126 7 ) ) -RRB- cord-005453-4057qib7 13126 8 , , , cord-005453-4057qib7 13126 9 IFN IFN NNP cord-005453-4057qib7 13126 10 - - HYPH cord-005453-4057qib7 13126 11 γ γ NNP cord-005453-4057qib7 13126 12 ( ( -LRB- cord-005453-4057qib7 13126 13 r=0.868 r=0.868 NNP cord-005453-4057qib7 13126 14 # # NN cord-005453-4057qib7 13126 15 ) ) -RRB- cord-005453-4057qib7 13126 16 , , . cord-005453-4057qib7 13127 1 MCP-1 MCP-1 NNP cord-005453-4057qib7 13128 1 ( ( -LRB- cord-005453-4057qib7 13128 2 593±242 593±242 CD cord-005453-4057qib7 13128 3 vs vs IN cord-005453-4057qib7 13128 4 547±223 547±223 CD cord-005453-4057qib7 13128 5 pg pg NN cord-005453-4057qib7 13128 6 / / SYM cord-005453-4057qib7 13128 7 ml ml NN cord-005453-4057qib7 13128 8 ) ) -RRB- cord-005453-4057qib7 13128 9 . . . cord-005453-4057qib7 13129 1 Conclusions conclusion NNS cord-005453-4057qib7 13129 2 : : : cord-005453-4057qib7 13130 1 Blasts blast NNS cord-005453-4057qib7 13130 2 are be VBP cord-005453-4057qib7 13130 3 regularly regularly RB cord-005453-4057qib7 13130 4 converted convert VBN cord-005453-4057qib7 13130 5 to to IN cord-005453-4057qib7 13130 6 DC DC NNP cord-005453-4057qib7 13130 7 leu leu NNP cord-005453-4057qib7 13130 8 in in IN cord-005453-4057qib7 13130 9 the the DT cord-005453-4057qib7 13130 10 presence presence NN cord-005453-4057qib7 13130 11 of of IN cord-005453-4057qib7 13130 12 MNC MNC NNP cord-005453-4057qib7 13130 13 - - HYPH cord-005453-4057qib7 13130 14 methods method NNS cord-005453-4057qib7 13130 15 and and CC cord-005453-4057qib7 13130 16 WB WB NNP cord-005453-4057qib7 13130 17 - - HYPH cord-005453-4057qib7 13130 18 kits kit NNS cord-005453-4057qib7 13130 19 ( ( -LRB- cord-005453-4057qib7 13130 20 simulating simulate VBG cord-005453-4057qib7 13130 21 the the DT cord-005453-4057qib7 13130 22 in in IN cord-005453-4057qib7 13130 23 vivo vivo NN cord-005453-4057qib7 13130 24 microenvironment microenvironment NN cord-005453-4057qib7 13130 25 ) ) -RRB- cord-005453-4057qib7 13130 26 . . . cord-005453-4057qib7 13131 1 T T NNP cord-005453-4057qib7 13131 2 - - HYPH cord-005453-4057qib7 13131 3 cells cell NNS cord-005453-4057qib7 13131 4 ' ' POS cord-005453-4057qib7 13131 5 coculture coculture NN cord-005453-4057qib7 13131 6 with with IN cord-005453-4057qib7 13131 7 DC/ DC/ -RRB- cord-005453-4057qib7 13131 8 DC DC NNP cord-005453-4057qib7 13131 9 leu leu NNP cord-005453-4057qib7 13131 10 after after IN cord-005453-4057qib7 13131 11 MLC MLC NNP cord-005453-4057qib7 13131 12 induces induce VBZ cord-005453-4057qib7 13131 13 and and CC cord-005453-4057qib7 13131 14 improves improve VBZ cord-005453-4057qib7 13131 15 antileukemic antileukemic NNP cord-005453-4057qib7 13131 16 T T NNP cord-005453-4057qib7 13131 17 - - HYPH cord-005453-4057qib7 13131 18 cell cell NN cord-005453-4057qib7 13131 19 activation activation NN cord-005453-4057qib7 13131 20 compared compare VBN cord-005453-4057qib7 13131 21 to to IN cord-005453-4057qib7 13131 22 controls control NNS cord-005453-4057qib7 13131 23 . . . cord-005453-4057qib7 13132 1 Blast blast NN cord-005453-4057qib7 13132 2 - - HYPH cord-005453-4057qib7 13132 3 cytotoxicity cytotoxicity NN cord-005453-4057qib7 13132 4 correlates correlate VBZ cord-005453-4057qib7 13132 5 with with IN cord-005453-4057qib7 13132 6 proportions proportion NNS cord-005453-4057qib7 13132 7 of of IN cord-005453-4057qib7 13132 8 DC DC NNP cord-005453-4057qib7 13132 9 / / SYM cord-005453-4057qib7 13132 10 DC DC NNP cord-005453-4057qib7 13132 11 leu leu NNP cord-005453-4057qib7 13132 12 -and -and HYPH cord-005453-4057qib7 13132 13 T t NN cord-005453-4057qib7 13132 14 - - HYPH cord-005453-4057qib7 13132 15 cell cell NN cord-005453-4057qib7 13132 16 subtypes subtype NNS cord-005453-4057qib7 13132 17 and and CC cord-005453-4057qib7 13132 18 released release VBN cord-005453-4057qib7 13132 19 cytokines cytokine NNS cord-005453-4057qib7 13132 20 . . . cord-005453-4057qib7 13133 1 These these DT cord-005453-4057qib7 13133 2 data datum NNS cord-005453-4057qib7 13133 3 support support VBP cord-005453-4057qib7 13133 4 a a DT cord-005453-4057qib7 13133 5 role role NN cord-005453-4057qib7 13133 6 of of IN cord-005453-4057qib7 13133 7 antigen antigen NN cord-005453-4057qib7 13133 8 presentation presentation NN cord-005453-4057qib7 13133 9 by by IN cord-005453-4057qib7 13133 10 leukemic leukemic JJ cord-005453-4057qib7 13133 11 cells cell NNS cord-005453-4057qib7 13133 12 ( ( -LRB- cord-005453-4057qib7 13133 13 DC DC NNP cord-005453-4057qib7 13133 14 leu leu NNP cord-005453-4057qib7 13133 15 ) ) -RRB- cord-005453-4057qib7 13133 16 for for IN cord-005453-4057qib7 13133 17 the the DT cord-005453-4057qib7 13133 18 stimulation stimulation NN cord-005453-4057qib7 13133 19 of of IN cord-005453-4057qib7 13133 20 an an DT cord-005453-4057qib7 13133 21 immune immune JJ cord-005453-4057qib7 13133 22 response response NN cord-005453-4057qib7 13133 23 in in IN cord-005453-4057qib7 13133 24 AML AML NNP cord-005453-4057qib7 13133 25 in in IN cord-005453-4057qib7 13133 26 vitro vitro FW cord-005453-4057qib7 13133 27 and and CC cord-005453-4057qib7 13133 28 possibly possibly RB cord-005453-4057qib7 13133 29 in in IN cord-005453-4057qib7 13133 30 vivo vivo NNP cord-005453-4057qib7 13133 31 . . . cord-005453-4057qib7 13134 1 Disclosure disclosure NN cord-005453-4057qib7 13134 2 : : : cord-005453-4057qib7 13134 3 Nothing nothing NN cord-005453-4057qib7 13134 4 to to TO cord-005453-4057qib7 13134 5 declare declare VB cord-005453-4057qib7 13134 6 Evaluation Evaluation NNP cord-005453-4057qib7 13134 7 1 1 CD cord-005453-4057qib7 13134 8 year year NN cord-005453-4057qib7 13134 9 after after IN cord-005453-4057qib7 13134 10 the the DT cord-005453-4057qib7 13134 11 launch launch NN cord-005453-4057qib7 13134 12 of of IN cord-005453-4057qib7 13134 13 the the DT cord-005453-4057qib7 13134 14 motion motion NN cord-005453-4057qib7 13134 15 comic comic JJ cord-005453-4057qib7 13134 16 immuno immuno NNP cord-005453-4057qib7 13134 17 - - HYPH cord-005453-4057qib7 13134 18 T t JJ cord-005453-4057qib7 13134 19 , , , cord-005453-4057qib7 13134 20 explaining explain VBG cord-005453-4057qib7 13134 21 patients patient NNS cord-005453-4057qib7 13134 22 and and CC cord-005453-4057qib7 13134 23 their -PRON- PRP$ cord-005453-4057qib7 13134 24 caregivers caregiver NNS cord-005453-4057qib7 13134 25 how how WRB cord-005453-4057qib7 13134 26 immunotherapy immunotherapy NN cord-005453-4057qib7 13134 27 strategies strategy NNS cord-005453-4057qib7 13134 28 work work VBP cord-005453-4057qib7 13134 29 Background background NN cord-005453-4057qib7 13134 30 : : : cord-005453-4057qib7 13135 1 One one CD cord-005453-4057qib7 13135 2 year year NN cord-005453-4057qib7 13135 3 ago ago RB cord-005453-4057qib7 13135 4 , , , cord-005453-4057qib7 13135 5 the the DT cord-005453-4057qib7 13135 6 first first JJ cord-005453-4057qib7 13135 7 version version NN cord-005453-4057qib7 13135 8 of of IN cord-005453-4057qib7 13135 9 Immuno Immuno NNP cord-005453-4057qib7 13135 10 - - HYPH cord-005453-4057qib7 13135 11 T T NNP cord-005453-4057qib7 13135 12 , , , cord-005453-4057qib7 13135 13 a a DT cord-005453-4057qib7 13135 14 motion motion NN cord-005453-4057qib7 13135 15 comic comic JJ cord-005453-4057qib7 13135 16 explaining explaining NN cord-005453-4057qib7 13135 17 to to IN cord-005453-4057qib7 13135 18 patients patient NNS cord-005453-4057qib7 13135 19 and and CC cord-005453-4057qib7 13135 20 caregivers caregiver NNS cord-005453-4057qib7 13135 21 how how WRB cord-005453-4057qib7 13135 22 immunotherapy immunotherapy NN cord-005453-4057qib7 13135 23 strategies strategy NNS cord-005453-4057qib7 13135 24 work work VBP cord-005453-4057qib7 13135 25 , , , cord-005453-4057qib7 13135 26 was be VBD cord-005453-4057qib7 13135 27 released release VBN cord-005453-4057qib7 13135 28 . . . cord-005453-4057qib7 13136 1 People People NNS cord-005453-4057qib7 13136 2 were be VBD cord-005453-4057qib7 13136 3 informed inform VBN cord-005453-4057qib7 13136 4 on on IN cord-005453-4057qib7 13136 5 and and CC cord-005453-4057qib7 13136 6 inspired inspire VBN cord-005453-4057qib7 13136 7 to to TO cord-005453-4057qib7 13136 8 use use VB cord-005453-4057qib7 13136 9 the the DT cord-005453-4057qib7 13136 10 application application NN cord-005453-4057qib7 13136 11 during during IN cord-005453-4057qib7 13136 12 ( ( -LRB- cord-005453-4057qib7 13136 13 inter)national inter)national NNP cord-005453-4057qib7 13136 14 meetings meeting NNS cord-005453-4057qib7 13136 15 and and CC cord-005453-4057qib7 13136 16 events event NNS cord-005453-4057qib7 13136 17 for for IN cord-005453-4057qib7 13136 18 the the DT cord-005453-4057qib7 13136 19 general general JJ cord-005453-4057qib7 13136 20 public public NN cord-005453-4057qib7 13136 21 . . . cord-005453-4057qib7 13137 1 Meanwhile meanwhile RB cord-005453-4057qib7 13137 2 , , , cord-005453-4057qib7 13137 3 the the DT cord-005453-4057qib7 13137 4 motion motion NN cord-005453-4057qib7 13137 5 comic comic NN cord-005453-4057qib7 13137 6 was be VBD cord-005453-4057qib7 13137 7 further further RB cord-005453-4057qib7 13137 8 refined refine VBN cord-005453-4057qib7 13137 9 and and CC cord-005453-4057qib7 13137 10 adapted adapt VBN cord-005453-4057qib7 13137 11 into into IN cord-005453-4057qib7 13137 12 a a DT cord-005453-4057qib7 13137 13 second second JJ cord-005453-4057qib7 13137 14 version version NN cord-005453-4057qib7 13137 15 , , , cord-005453-4057qib7 13137 16 based base VBN cord-005453-4057qib7 13137 17 on on IN cord-005453-4057qib7 13137 18 the the DT cord-005453-4057qib7 13137 19 evaluations evaluation NNS cord-005453-4057qib7 13137 20 we -PRON- PRP cord-005453-4057qib7 13137 21 've have VB cord-005453-4057qib7 13137 22 collected collect VBN cord-005453-4057qib7 13137 23 on on IN cord-005453-4057qib7 13137 24 the the DT cord-005453-4057qib7 13137 25 first first JJ cord-005453-4057qib7 13137 26 version version NN cord-005453-4057qib7 13137 27 . . . cord-005453-4057qib7 13138 1 Adaptations adaptation NNS cord-005453-4057qib7 13138 2 included include VBD cord-005453-4057qib7 13138 3 a a DT cord-005453-4057qib7 13138 4 multi multi JJ cord-005453-4057qib7 13138 5 - - JJ cord-005453-4057qib7 13138 6 language language JJ cord-005453-4057qib7 13138 7 tool tool NN cord-005453-4057qib7 13138 8 ( ( -LRB- cord-005453-4057qib7 13138 9 currently currently RB cord-005453-4057qib7 13138 10 6 6 CD cord-005453-4057qib7 13138 11 languages language NNS cord-005453-4057qib7 13138 12 ) ) -RRB- cord-005453-4057qib7 13138 13 , , , cord-005453-4057qib7 13138 14 increased increase VBN cord-005453-4057qib7 13138 15 user user NN cord-005453-4057qib7 13138 16 friendliness friendliness NN cord-005453-4057qib7 13138 17 , , , cord-005453-4057qib7 13138 18 and and CC cord-005453-4057qib7 13138 19 a a DT cord-005453-4057qib7 13138 20 new new JJ cord-005453-4057qib7 13138 21 supporting support VBG cord-005453-4057qib7 13138 22 musical musical JJ cord-005453-4057qib7 13138 23 score score NN cord-005453-4057qib7 13138 24 . . . cord-005453-4057qib7 13139 1 Also also RB cord-005453-4057qib7 13139 2 , , , cord-005453-4057qib7 13139 3 a a DT cord-005453-4057qib7 13139 4 website website NN cord-005453-4057qib7 13139 5 was be VBD cord-005453-4057qib7 13139 6 launched launch VBN cord-005453-4057qib7 13139 7 from from IN cord-005453-4057qib7 13139 8 which which WDT cord-005453-4057qib7 13139 9 the the DT cord-005453-4057qib7 13139 10 second second JJ cord-005453-4057qib7 13139 11 version version NN cord-005453-4057qib7 13139 12 could could MD cord-005453-4057qib7 13139 13 be be VB cord-005453-4057qib7 13139 14 downloaded download VBN cord-005453-4057qib7 13139 15 on on IN cord-005453-4057qib7 13139 16 tablet tablet NN cord-005453-4057qib7 13139 17 or or CC cord-005453-4057qib7 13139 18 smartphone smartphone NN cord-005453-4057qib7 13139 19 ( ( -LRB- cord-005453-4057qib7 13139 20 both both DT cord-005453-4057qib7 13139 21 android android NNP cord-005453-4057qib7 13139 22 and and CC cord-005453-4057qib7 13139 23 apple apple NNP cord-005453-4057qib7 13139 24 ) ) -RRB- cord-005453-4057qib7 13139 25 and and CC cord-005453-4057qib7 13139 26 a a DT cord-005453-4057qib7 13139 27 new new JJ cord-005453-4057qib7 13139 28 online online JJ cord-005453-4057qib7 13139 29 evaluation evaluation NN cord-005453-4057qib7 13139 30 form form NN cord-005453-4057qib7 13139 31 could could MD cord-005453-4057qib7 13139 32 be be VB cord-005453-4057qib7 13139 33 filled fill VBN cord-005453-4057qib7 13139 34 in in IN cord-005453-4057qib7 13139 35 . . . cord-005453-4057qib7 13140 1 In in IN cord-005453-4057qib7 13140 2 10 10 CD cord-005453-4057qib7 13140 3 months month NNS cord-005453-4057qib7 13140 4 , , , cord-005453-4057qib7 13140 5 40 40 CD cord-005453-4057qib7 13140 6 people people NNS cord-005453-4057qib7 13140 7 have have VBP cord-005453-4057qib7 13140 8 evaluated evaluate VBN cord-005453-4057qib7 13140 9 the the DT cord-005453-4057qib7 13140 10 motion motion NN cord-005453-4057qib7 13140 11 comic comic JJ cord-005453-4057qib7 13140 12 online online RB cord-005453-4057qib7 13140 13 , , , cord-005453-4057qib7 13140 14 and and CC cord-005453-4057qib7 13140 15 these these DT cord-005453-4057qib7 13140 16 results result NNS cord-005453-4057qib7 13140 17 are be VBP cord-005453-4057qib7 13140 18 presented present VBN cord-005453-4057qib7 13140 19 here here RB cord-005453-4057qib7 13140 20 , , , cord-005453-4057qib7 13140 21 as as RB cord-005453-4057qib7 13140 22 well well RB cord-005453-4057qib7 13140 23 as as IN cord-005453-4057qib7 13140 24 our -PRON- PRP$ cord-005453-4057qib7 13140 25 future future JJ cord-005453-4057qib7 13140 26 plans plan NNS cord-005453-4057qib7 13140 27 within within IN cord-005453-4057qib7 13140 28 the the DT cord-005453-4057qib7 13140 29 Immuno Immuno NNP cord-005453-4057qib7 13140 30 - - HYPH cord-005453-4057qib7 13140 31 T T NNP cord-005453-4057qib7 13140 32 program program NN cord-005453-4057qib7 13140 33 . . . cord-005453-4057qib7 13141 1 Methods method NNS cord-005453-4057qib7 13141 2 : : : cord-005453-4057qib7 13141 3 Through through IN cord-005453-4057qib7 13141 4 an an DT cord-005453-4057qib7 13141 5 online online JJ cord-005453-4057qib7 13141 6 questionnaire questionnaire NN cord-005453-4057qib7 13141 7 , , , cord-005453-4057qib7 13141 8 41 41 CD cord-005453-4057qib7 13141 9 participants participant NNS cord-005453-4057qib7 13141 10 from from IN cord-005453-4057qib7 13141 11 Belgium Belgium NNP cord-005453-4057qib7 13141 12 ( ( -LRB- cord-005453-4057qib7 13141 13 n=38 n=38 NNP cord-005453-4057qib7 13141 14 ) ) -RRB- cord-005453-4057qib7 13141 15 and and CC cord-005453-4057qib7 13141 16 the the DT cord-005453-4057qib7 13141 17 Netherlands Netherlands NNP cord-005453-4057qib7 13141 18 ( ( -LRB- cord-005453-4057qib7 13141 19 n=3 n=3 NN cord-005453-4057qib7 13141 20 ) ) -RRB- cord-005453-4057qib7 13141 21 have have VBP cord-005453-4057qib7 13141 22 evaluated evaluate VBN cord-005453-4057qib7 13141 23 the the DT cord-005453-4057qib7 13141 24 Dutch dutch JJ cord-005453-4057qib7 13141 25 version version NN cord-005453-4057qib7 13141 26 , , , cord-005453-4057qib7 13141 27 and and CC cord-005453-4057qib7 13141 28 4 4 CD cord-005453-4057qib7 13141 29 Belgian belgian JJ cord-005453-4057qib7 13141 30 participants participant NNS cord-005453-4057qib7 13141 31 evaluated evaluate VBD cord-005453-4057qib7 13141 32 the the DT cord-005453-4057qib7 13141 33 French french JJ cord-005453-4057qib7 13141 34 version version NN cord-005453-4057qib7 13141 35 of of IN cord-005453-4057qib7 13141 36 the the DT cord-005453-4057qib7 13141 37 motion motion NN cord-005453-4057qib7 13141 38 comic comic NN cord-005453-4057qib7 13141 39 . . . cord-005453-4057qib7 13142 1 Results result NNS cord-005453-4057qib7 13142 2 : : : cord-005453-4057qib7 13143 1 The the DT cord-005453-4057qib7 13143 2 total total JJ cord-005453-4057qib7 13143 3 group group NN cord-005453-4057qib7 13143 4 ( ( -LRB- cord-005453-4057qib7 13143 5 n=45 n=45 NNS cord-005453-4057qib7 13143 6 ) ) -RRB- cord-005453-4057qib7 13143 7 consisted consist VBD cord-005453-4057qib7 13143 8 of of IN cord-005453-4057qib7 13143 9 patients patient NNS cord-005453-4057qib7 13143 10 ( ( -LRB- cord-005453-4057qib7 13143 11 n=15 n=15 NNP cord-005453-4057qib7 13143 12 ) ) -RRB- cord-005453-4057qib7 13143 13 and and CC cord-005453-4057qib7 13143 14 their -PRON- PRP$ cord-005453-4057qib7 13143 15 families family NNS cord-005453-4057qib7 13143 16 ( ( -LRB- cord-005453-4057qib7 13143 17 n=2 n=2 NNS cord-005453-4057qib7 13143 18 ) ) -RRB- cord-005453-4057qib7 13143 19 , , , cord-005453-4057qib7 13143 20 general general JJ cord-005453-4057qib7 13143 21 public public NN cord-005453-4057qib7 13143 22 ( ( -LRB- cord-005453-4057qib7 13143 23 n=10 n=10 NNP cord-005453-4057qib7 13143 24 ) ) -RRB- cord-005453-4057qib7 13143 25 , , , cord-005453-4057qib7 13143 26 students student NNS cord-005453-4057qib7 13143 27 ( ( -LRB- cord-005453-4057qib7 13143 28 n=7 n=7 NNS cord-005453-4057qib7 13143 29 ) ) -RRB- cord-005453-4057qib7 13143 30 , , , cord-005453-4057qib7 13143 31 health health NN cord-005453-4057qib7 13143 32 care care NN cord-005453-4057qib7 13143 33 professionals professional NNS cord-005453-4057qib7 13143 34 ( ( -LRB- cord-005453-4057qib7 13143 35 n=4 n=4 NNP cord-005453-4057qib7 13143 36 ) ) -RRB- cord-005453-4057qib7 13143 37 , , , cord-005453-4057qib7 13143 38 researchers researcher NNS cord-005453-4057qib7 13143 39 ( ( -LRB- cord-005453-4057qib7 13143 40 n=5 n=5 NNP cord-005453-4057qib7 13143 41 ) ) -RRB- cord-005453-4057qib7 13143 42 and and CC cord-005453-4057qib7 13143 43 kindergarten kindergarten NN cord-005453-4057qib7 13143 44 teachers teacher NNS cord-005453-4057qib7 13143 45 ( ( -LRB- cord-005453-4057qib7 13143 46 n=2 n=2 NNS cord-005453-4057qib7 13143 47 ) ) -RRB- cord-005453-4057qib7 13143 48 . . . cord-005453-4057qib7 13144 1 Participants participant NNS cord-005453-4057qib7 13144 2 ' ' POS cord-005453-4057qib7 13144 3 age age NN cord-005453-4057qib7 13144 4 ranged range VBD cord-005453-4057qib7 13144 5 from from IN cord-005453-4057qib7 13144 6 19 19 CD cord-005453-4057qib7 13144 7 to to TO cord-005453-4057qib7 13144 8 80 80 CD cord-005453-4057qib7 13144 9 years year NNS cord-005453-4057qib7 13144 10 , , , cord-005453-4057qib7 13144 11 with with IN cord-005453-4057qib7 13144 12 an an DT cord-005453-4057qib7 13144 13 even even JJ cord-005453-4057qib7 13144 14 distribution distribution NN cord-005453-4057qib7 13144 15 amongst amongst IN cord-005453-4057qib7 13144 16 the the DT cord-005453-4057qib7 13144 17 different different JJ cord-005453-4057qib7 13144 18 generations generation NNS cord-005453-4057qib7 13144 19 . . . cord-005453-4057qib7 13145 1 The the DT cord-005453-4057qib7 13145 2 majority majority NN cord-005453-4057qib7 13145 3 of of IN cord-005453-4057qib7 13145 4 the the DT cord-005453-4057qib7 13145 5 evaluators evaluator NNS cord-005453-4057qib7 13145 6 ( ( -LRB- cord-005453-4057qib7 13145 7 97,8 97,8 CD cord-005453-4057qib7 13145 8 % % NN cord-005453-4057qib7 13145 9 , , , cord-005453-4057qib7 13145 10 n=44 n=44 NNP cord-005453-4057qib7 13145 11 ) ) -RRB- cord-005453-4057qib7 13145 12 thought think VBD cord-005453-4057qib7 13145 13 the the DT cord-005453-4057qib7 13145 14 motion motion NN cord-005453-4057qib7 13145 15 comic comic NN cord-005453-4057qib7 13145 16 is be VBZ cord-005453-4057qib7 13145 17 a a DT cord-005453-4057qib7 13145 18 good good JJ cord-005453-4057qib7 13145 19 way way NN cord-005453-4057qib7 13145 20 to to TO cord-005453-4057qib7 13145 21 explain explain VB cord-005453-4057qib7 13145 22 immunotherapy immunotherapy NN cord-005453-4057qib7 13145 23 to to IN cord-005453-4057qib7 13145 24 patients patient NNS cord-005453-4057qib7 13145 25 . . . cord-005453-4057qib7 13146 1 23 23 CD cord-005453-4057qib7 13146 2 individuals individual NNS cord-005453-4057qib7 13146 3 ( ( -LRB- cord-005453-4057qib7 13146 4 51,1 51,1 CD cord-005453-4057qib7 13146 5 % % NN cord-005453-4057qib7 13146 6 ) ) -RRB- cord-005453-4057qib7 13146 7 felt feel VBD cord-005453-4057qib7 13146 8 mainly mainly RB cord-005453-4057qib7 13146 9 interested interested JJ cord-005453-4057qib7 13146 10 after after IN cord-005453-4057qib7 13146 11 watching watch VBG cord-005453-4057qib7 13146 12 immuno immuno NNP cord-005453-4057qib7 13146 13 - - HYPH cord-005453-4057qib7 13146 14 T T NNP cord-005453-4057qib7 13146 15 , , , cord-005453-4057qib7 13146 16 and and CC cord-005453-4057qib7 13146 17 a a DT cord-005453-4057qib7 13146 18 total total NN cord-005453-4057qib7 13146 19 of of IN cord-005453-4057qib7 13146 20 32 32 CD cord-005453-4057qib7 13146 21 participants participant NNS cord-005453-4057qib7 13146 22 ( ( -LRB- cord-005453-4057qib7 13146 23 71,1 71,1 CD cord-005453-4057qib7 13146 24 % % NN cord-005453-4057qib7 13146 25 ) ) -RRB- cord-005453-4057qib7 13146 26 felt feel VBD cord-005453-4057qib7 13146 27 hopeful hopeful JJ cord-005453-4057qib7 13146 28 or or CC cord-005453-4057qib7 13146 29 motivated motivated JJ cord-005453-4057qib7 13146 30 . . . cord-005453-4057qib7 13147 1 Focussing focusse VBG cord-005453-4057qib7 13147 2 on on IN cord-005453-4057qib7 13147 3 the the DT cord-005453-4057qib7 13147 4 patient patient NN cord-005453-4057qib7 13147 5 group group NN cord-005453-4057qib7 13147 6 ( ( -LRB- cord-005453-4057qib7 13147 7 n=15 n=15 NNP cord-005453-4057qib7 13147 8 ) ) -RRB- cord-005453-4057qib7 13147 9 , , , cord-005453-4057qib7 13147 10 all all DT cord-005453-4057qib7 13147 11 of of IN cord-005453-4057qib7 13147 12 the the DT cord-005453-4057qib7 13147 13 responders responder NNS cord-005453-4057qib7 13147 14 think think VBP cord-005453-4057qib7 13147 15 the the DT cord-005453-4057qib7 13147 16 Immuno Immuno NNP cord-005453-4057qib7 13147 17 - - HYPH cord-005453-4057qib7 13147 18 T T NNP cord-005453-4057qib7 13147 19 motion motion NN cord-005453-4057qib7 13147 20 comic comic NN cord-005453-4057qib7 13147 21 is be VBZ cord-005453-4057qib7 13147 22 a a DT cord-005453-4057qib7 13147 23 good good JJ cord-005453-4057qib7 13147 24 tool tool NN cord-005453-4057qib7 13147 25 to to TO cord-005453-4057qib7 13147 26 use use VB cord-005453-4057qib7 13147 27 in in IN cord-005453-4057qib7 13147 28 a a DT cord-005453-4057qib7 13147 29 patient patient JJ cord-005453-4057qib7 13147 30 - - HYPH cord-005453-4057qib7 13147 31 doctor doctor NN cord-005453-4057qib7 13147 32 consultation consultation NN cord-005453-4057qib7 13147 33 . . . cord-005453-4057qib7 13148 1 11 11 CD cord-005453-4057qib7 13148 2 patients patient NNS cord-005453-4057qib7 13148 3 ( ( -LRB- cord-005453-4057qib7 13148 4 73,3 73,3 CD cord-005453-4057qib7 13148 5 % % NN cord-005453-4057qib7 13148 6 ) ) -RRB- cord-005453-4057qib7 13148 7 felt feel VBD cord-005453-4057qib7 13148 8 hopeful hopeful JJ cord-005453-4057qib7 13148 9 and/or and/or CC cord-005453-4057qib7 13148 10 motivated motivated JJ cord-005453-4057qib7 13148 11 after after IN cord-005453-4057qib7 13148 12 watching watch VBG cord-005453-4057qib7 13148 13 the the DT cord-005453-4057qib7 13148 14 whole whole JJ cord-005453-4057qib7 13148 15 motion motion NN cord-005453-4057qib7 13148 16 comic comic NN cord-005453-4057qib7 13148 17 , , , cord-005453-4057qib7 13148 18 while while IN cord-005453-4057qib7 13148 19 3 3 CD cord-005453-4057qib7 13148 20 of of IN cord-005453-4057qib7 13148 21 them -PRON- PRP cord-005453-4057qib7 13148 22 ( ( -LRB- cord-005453-4057qib7 13148 23 20 20 CD cord-005453-4057qib7 13148 24 % % NN cord-005453-4057qib7 13148 25 ) ) -RRB- cord-005453-4057qib7 13148 26 felt feel VBD cord-005453-4057qib7 13148 27 combative combative JJ cord-005453-4057qib7 13148 28 and and CC cord-005453-4057qib7 13148 29 5 5 CD cord-005453-4057qib7 13148 30 ( ( -LRB- cord-005453-4057qib7 13148 31 33,3 33,3 CD cord-005453-4057qib7 13148 32 % % NN cord-005453-4057qib7 13148 33 ) ) -RRB- cord-005453-4057qib7 13148 34 felt feel VBD cord-005453-4057qib7 13148 35 gripped grip VBN cord-005453-4057qib7 13148 36 and and CC cord-005453-4057qib7 13148 37 intrigued intrigued JJ cord-005453-4057qib7 13148 38 . . . cord-005453-4057qib7 13149 1 As as IN cord-005453-4057qib7 13149 2 for for IN cord-005453-4057qib7 13149 3 the the DT cord-005453-4057qib7 13149 4 new new JJ cord-005453-4057qib7 13149 5 musical musical JJ cord-005453-4057qib7 13149 6 score score NN cord-005453-4057qib7 13149 7 , , , cord-005453-4057qib7 13149 8 35 35 CD cord-005453-4057qib7 13149 9 participants participant NNS cord-005453-4057qib7 13149 10 ( ( -LRB- cord-005453-4057qib7 13149 11 77,7 77,7 CD cord-005453-4057qib7 13149 12 % % NN cord-005453-4057qib7 13149 13 ) ) -RRB- cord-005453-4057qib7 13149 14 think think VBP cord-005453-4057qib7 13149 15 the the DT cord-005453-4057qib7 13149 16 music music NN cord-005453-4057qib7 13149 17 is be VBZ cord-005453-4057qib7 13149 18 suitable suitable JJ cord-005453-4057qib7 13149 19 for for IN cord-005453-4057qib7 13149 20 the the DT cord-005453-4057qib7 13149 21 app app NN cord-005453-4057qib7 13149 22 , , , cord-005453-4057qib7 13149 23 while while IN cord-005453-4057qib7 13149 24 6 6 CD cord-005453-4057qib7 13149 25 evaluators evaluator NNS cord-005453-4057qib7 13149 26 ( ( -LRB- cord-005453-4057qib7 13149 27 13,3 13,3 CD cord-005453-4057qib7 13149 28 % % NN cord-005453-4057qib7 13149 29 ) ) -RRB- cord-005453-4057qib7 13149 30 think think VBP cord-005453-4057qib7 13149 31 the the DT cord-005453-4057qib7 13149 32 new new JJ cord-005453-4057qib7 13149 33 music music NN cord-005453-4057qib7 13149 34 is be VBZ cord-005453-4057qib7 13149 35 not not RB cord-005453-4057qib7 13149 36 or or CC cord-005453-4057qib7 13149 37 not not RB cord-005453-4057qib7 13149 38 at at RB cord-005453-4057qib7 13149 39 all all RB cord-005453-4057qib7 13149 40 fitted fit VBN cord-005453-4057qib7 13149 41 to to TO cord-005453-4057qib7 13149 42 support support VB cord-005453-4057qib7 13149 43 the the DT cord-005453-4057qib7 13149 44 motion motion NN cord-005453-4057qib7 13149 45 comic comic NN cord-005453-4057qib7 13149 46 . . . cord-005453-4057qib7 13150 1 Conclusions conclusion NNS cord-005453-4057qib7 13150 2 : : : cord-005453-4057qib7 13151 1 The the DT cord-005453-4057qib7 13151 2 detailed detailed JJ cord-005453-4057qib7 13151 3 evaluations evaluation NNS cord-005453-4057qib7 13151 4 allow allow VBP cord-005453-4057qib7 13151 5 us -PRON- PRP cord-005453-4057qib7 13151 6 to to TO cord-005453-4057qib7 13151 7 further further RB cord-005453-4057qib7 13151 8 improve improve VB cord-005453-4057qib7 13151 9 Immuno Immuno NNP cord-005453-4057qib7 13151 10 - - HYPH cord-005453-4057qib7 13151 11 T T NNP cord-005453-4057qib7 13151 12 , , , cord-005453-4057qib7 13151 13 and and CC cord-005453-4057qib7 13151 14 aid aid VB cord-005453-4057qib7 13151 15 us -PRON- PRP cord-005453-4057qib7 13151 16 in in IN cord-005453-4057qib7 13151 17 the the DT cord-005453-4057qib7 13151 18 development development NN cord-005453-4057qib7 13151 19 of of IN cord-005453-4057qib7 13151 20 other other JJ cord-005453-4057qib7 13151 21 motion motion NN cord-005453-4057qib7 13151 22 comics comic_strip NNS cord-005453-4057qib7 13151 23 we -PRON- PRP cord-005453-4057qib7 13151 24 plan plan VBP cord-005453-4057qib7 13151 25 to to TO cord-005453-4057qib7 13151 26 release release VB cord-005453-4057qib7 13151 27 under under IN cord-005453-4057qib7 13151 28 the the DT cord-005453-4057qib7 13151 29 Cancer Cancer NNP cord-005453-4057qib7 13151 30 - - HYPH cord-005453-4057qib7 13151 31 T T NNP cord-005453-4057qib7 13151 32 in in IN cord-005453-4057qib7 13151 33 motion motion NN cord-005453-4057qib7 13151 34 umbrella umbrella NN cord-005453-4057qib7 13151 35 . . . cord-005453-4057qib7 13152 1 With with IN cord-005453-4057qib7 13152 2 the the DT cord-005453-4057qib7 13152 3 current current JJ cord-005453-4057qib7 13152 4 version version NN cord-005453-4057qib7 13152 5 of of IN cord-005453-4057qib7 13152 6 Immuno Immuno NNP cord-005453-4057qib7 13152 7 - - HYPH cord-005453-4057qib7 13152 8 T T NNP cord-005453-4057qib7 13152 9 , , , cord-005453-4057qib7 13152 10 a a DT cord-005453-4057qib7 13152 11 single single JJ cord-005453-4057qib7 13152 12 - - HYPH cord-005453-4057qib7 13152 13 center center NN cord-005453-4057qib7 13152 14 pilot pilot NN cord-005453-4057qib7 13152 15 study study NN cord-005453-4057qib7 13152 16 is be VBZ cord-005453-4057qib7 13152 17 being be VBG cord-005453-4057qib7 13152 18 set set VBN cord-005453-4057qib7 13152 19 up up RP cord-005453-4057qib7 13152 20 , , , cord-005453-4057qib7 13152 21 to to TO cord-005453-4057qib7 13152 22 test test VB cord-005453-4057qib7 13152 23 the the DT cord-005453-4057qib7 13152 24 efficacy efficacy NN cord-005453-4057qib7 13152 25 and and CC cord-005453-4057qib7 13152 26 usability usability NN cord-005453-4057qib7 13152 27 of of IN cord-005453-4057qib7 13152 28 Immuno Immuno NNP cord-005453-4057qib7 13152 29 - - HYPH cord-005453-4057qib7 13152 30 T T NNP cord-005453-4057qib7 13152 31 , , , cord-005453-4057qib7 13152 32 based base VBN cord-005453-4057qib7 13152 33 on on IN cord-005453-4057qib7 13152 34 qualitative qualitative JJ cord-005453-4057qib7 13152 35 research research NN cord-005453-4057qib7 13152 36 during during IN cord-005453-4057qib7 13152 37 the the DT cord-005453-4057qib7 13152 38 experience experience NN cord-005453-4057qib7 13152 39 of of IN cord-005453-4057qib7 13152 40 the the DT cord-005453-4057qib7 13152 41 tool tool NN cord-005453-4057qib7 13152 42 , , , cord-005453-4057qib7 13152 43 and and CC cord-005453-4057qib7 13152 44 using use VBG cord-005453-4057qib7 13152 45 validated validate VBN cord-005453-4057qib7 13152 46 questionnaires questionnaire NNS cord-005453-4057qib7 13152 47 . . . cord-005453-4057qib7 13153 1 With with IN cord-005453-4057qib7 13153 2 this this DT cord-005453-4057qib7 13153 3 study study NN cord-005453-4057qib7 13153 4 we -PRON- PRP cord-005453-4057qib7 13153 5 want want VBP cord-005453-4057qib7 13153 6 to to TO cord-005453-4057qib7 13153 7 evaluate evaluate VB cord-005453-4057qib7 13153 8 the the DT cord-005453-4057qib7 13153 9 impact impact NN cord-005453-4057qib7 13153 10 of of IN cord-005453-4057qib7 13153 11 Immuno Immuno NNP cord-005453-4057qib7 13153 12 - - HYPH cord-005453-4057qib7 13153 13 T T NNP cord-005453-4057qib7 13153 14 on on IN cord-005453-4057qib7 13153 15 patient patient JJ cord-005453-4057qib7 13153 16 empowerment empowerment NN cord-005453-4057qib7 13153 17 , , , cord-005453-4057qib7 13153 18 and and CC cord-005453-4057qib7 13153 19 the the DT cord-005453-4057qib7 13153 20 decision decision NN cord-005453-4057qib7 13153 21 making make VBG cord-005453-4057qib7 13153 22 process process NN cord-005453-4057qib7 13153 23 . . . cord-005453-4057qib7 13154 1 The the DT cord-005453-4057qib7 13154 2 study study NN cord-005453-4057qib7 13154 3 protocol protocol NN cord-005453-4057qib7 13154 4 will will MD cord-005453-4057qib7 13154 5 be be VB cord-005453-4057qib7 13154 6 presented present VBN cord-005453-4057qib7 13154 7 at at IN cord-005453-4057qib7 13154 8 EBMT EBMT NNP cord-005453-4057qib7 13154 9 . . . cord-005453-4057qib7 13155 1 Disclosure disclosure NN cord-005453-4057qib7 13155 2 : : : cord-005453-4057qib7 13156 1 The the DT cord-005453-4057qib7 13156 2 development development NN cord-005453-4057qib7 13156 3 of of IN cord-005453-4057qib7 13156 4 Immuno Immuno NNP cord-005453-4057qib7 13156 5 - - HYPH cord-005453-4057qib7 13156 6 T T NNP cord-005453-4057qib7 13156 7 was be VBD cord-005453-4057qib7 13156 8 partly partly RB cord-005453-4057qib7 13156 9 financially financially RB cord-005453-4057qib7 13156 10 supported support VBN cord-005453-4057qib7 13156 11 by by IN cord-005453-4057qib7 13156 12 Celyad Celyad NNP cord-005453-4057qib7 13156 13 , , , cord-005453-4057qib7 13156 14 Calgene Calgene NNP cord-005453-4057qib7 13156 15 , , , cord-005453-4057qib7 13156 16 Novartis Novartis NNP cord-005453-4057qib7 13156 17 , , , cord-005453-4057qib7 13156 18 Roche Roche NNP cord-005453-4057qib7 13156 19 , , , cord-005453-4057qib7 13156 20 Amgen Amgen NNP cord-005453-4057qib7 13156 21 , , , cord-005453-4057qib7 13156 22 BMS BMS NNP cord-005453-4057qib7 13156 23 , , , cord-005453-4057qib7 13156 24 but but CC cord-005453-4057qib7 13156 25 these these DT cord-005453-4057qib7 13156 26 companies company NNS cord-005453-4057qib7 13156 27 did do VBD cord-005453-4057qib7 13156 28 not not RB cord-005453-4057qib7 13156 29 by by IN cord-005453-4057qib7 13156 30 any any DT cord-005453-4057qib7 13156 31 means mean NNS cord-005453-4057qib7 13156 32 influence influence NN cord-005453-4057qib7 13156 33 the the DT cord-005453-4057qib7 13156 34 contents content NNS cord-005453-4057qib7 13156 35 and and CC cord-005453-4057qib7 13156 36 development development NN cord-005453-4057qib7 13156 37 of of IN cord-005453-4057qib7 13156 38 the the DT cord-005453-4057qib7 13156 39 motion motion NN cord-005453-4057qib7 13156 40 comic comic NN cord-005453-4057qib7 13156 41 . . . cord-005453-4057qib7 13157 1 A a DT cord-005453-4057qib7 13157 2 therapeutic therapeutic JJ cord-005453-4057qib7 13157 3 strategy strategy NN cord-005453-4057qib7 13157 4 to to TO cord-005453-4057qib7 13157 5 trespass trespass VB cord-005453-4057qib7 13157 6 the the DT cord-005453-4057qib7 13157 7 blood blood NN cord-005453-4057qib7 13157 8 brain brain NN cord-005453-4057qib7 13157 9 barrier barrier NN cord-005453-4057qib7 13157 10 for for IN cord-005453-4057qib7 13157 11 adoptive adoptive JJ cord-005453-4057qib7 13157 12 NK NK NNP cord-005453-4057qib7 13157 13 cell cell NN cord-005453-4057qib7 13157 14 therapy therapy NN cord-005453-4057qib7 13157 15 in in IN cord-005453-4057qib7 13157 16 glioblastoma glioblastoma NNP cord-005453-4057qib7 13157 17 multiforme multiforme NN cord-005453-4057qib7 13157 18 induced induce VBN cord-005453-4057qib7 13157 19 rat rat NN cord-005453-4057qib7 13157 20 : : : cord-005453-4057qib7 13158 1 A a DT cord-005453-4057qib7 13158 2 preclinical preclinical JJ cord-005453-4057qib7 13158 3 study study NN cord-005453-4057qib7 13158 4 Background background NN cord-005453-4057qib7 13158 5 : : : cord-005453-4057qib7 13159 1 Glioblastoma Glioblastoma NNP cord-005453-4057qib7 13159 2 Multiforme Multiforme NNP cord-005453-4057qib7 13159 3 ( ( -LRB- cord-005453-4057qib7 13159 4 GBM GBM NNP cord-005453-4057qib7 13159 5 ) ) -RRB- cord-005453-4057qib7 13159 6 is be VBZ cord-005453-4057qib7 13159 7 among among IN cord-005453-4057qib7 13159 8 the the DT cord-005453-4057qib7 13159 9 most most RBS cord-005453-4057qib7 13159 10 common common JJ cord-005453-4057qib7 13159 11 and and CC cord-005453-4057qib7 13159 12 aggressive aggressive JJ cord-005453-4057qib7 13159 13 primary primary JJ cord-005453-4057qib7 13159 14 brain brain NN cord-005453-4057qib7 13159 15 tumors tumor NNS cord-005453-4057qib7 13159 16 with with IN cord-005453-4057qib7 13159 17 very very RB cord-005453-4057qib7 13159 18 poor poor JJ cord-005453-4057qib7 13159 19 prognosis prognosis NN cord-005453-4057qib7 13159 20 . . . cord-005453-4057qib7 13160 1 According accord VBG cord-005453-4057qib7 13160 2 to to IN cord-005453-4057qib7 13160 3 the the DT cord-005453-4057qib7 13160 4 Central Central NNP cord-005453-4057qib7 13160 5 Brain Brain NNP cord-005453-4057qib7 13160 6 Tumor Tumor NNP cord-005453-4057qib7 13160 7 Registry Registry NNP cord-005453-4057qib7 13160 8 of of IN cord-005453-4057qib7 13160 9 the the DT cord-005453-4057qib7 13160 10 United United NNP cord-005453-4057qib7 13160 11 States States NNP cord-005453-4057qib7 13160 12 , , , cord-005453-4057qib7 13160 13 central central JJ cord-005453-4057qib7 13160 14 nervous nervous JJ cord-005453-4057qib7 13160 15 system system NN cord-005453-4057qib7 13160 16 ( ( -LRB- cord-005453-4057qib7 13160 17 CNS CNS NNP cord-005453-4057qib7 13160 18 ) ) -RRB- cord-005453-4057qib7 13160 19 tumors tumor NNS cord-005453-4057qib7 13160 20 in in IN cord-005453-4057qib7 13160 21 pediatric pediatric JJ cord-005453-4057qib7 13160 22 patients patient NNS cord-005453-4057qib7 13160 23 ( ( -LRB- cord-005453-4057qib7 13160 24 ages age NNS cord-005453-4057qib7 13160 25 between between IN cord-005453-4057qib7 13160 26 0 0 CD cord-005453-4057qib7 13160 27 - - SYM cord-005453-4057qib7 13160 28 14 14 CD cord-005453-4057qib7 13160 29 years year NNS cord-005453-4057qib7 13160 30 old old JJ cord-005453-4057qib7 13160 31 ) ) -RRB- cord-005453-4057qib7 13160 32 are be VBP cord-005453-4057qib7 13160 33 the the DT cord-005453-4057qib7 13160 34 second second JJ cord-005453-4057qib7 13160 35 most most RBS cord-005453-4057qib7 13160 36 common common JJ cord-005453-4057qib7 13160 37 malignancies malignancy NNS cord-005453-4057qib7 13160 38 after after IN cord-005453-4057qib7 13160 39 blood blood NN cord-005453-4057qib7 13160 40 - - HYPH cord-005453-4057qib7 13160 41 born bear VBN cord-005453-4057qib7 13160 42 malignancies malignancy NNS cord-005453-4057qib7 13160 43 , , , cord-005453-4057qib7 13160 44 and and CC cord-005453-4057qib7 13160 45 the the DT cord-005453-4057qib7 13160 46 first first JJ cord-005453-4057qib7 13160 47 amongst amongst IN cord-005453-4057qib7 13160 48 solid solid JJ cord-005453-4057qib7 13160 49 tumors tumor NNS cord-005453-4057qib7 13160 50 , , , cord-005453-4057qib7 13160 51 and and CC cord-005453-4057qib7 13160 52 known know VBD cord-005453-4057qib7 13160 53 the the DT cord-005453-4057qib7 13160 54 most most RBS cord-005453-4057qib7 13160 55 common common JJ cord-005453-4057qib7 13160 56 cause cause NN cord-005453-4057qib7 13160 57 of of IN cord-005453-4057qib7 13160 58 cancer cancer NN cord-005453-4057qib7 13160 59 - - HYPH cord-005453-4057qib7 13160 60 related relate VBN cord-005453-4057qib7 13160 61 deaths death NNS cord-005453-4057qib7 13160 62 . . . cord-005453-4057qib7 13161 1 Although although IN cord-005453-4057qib7 13161 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 13161 3 stem stem NN cord-005453-4057qib7 13161 4 cell cell NN cord-005453-4057qib7 13161 5 transplantation transplantation NN cord-005453-4057qib7 13161 6 has have VBZ cord-005453-4057qib7 13161 7 been be VBN cord-005453-4057qib7 13161 8 exploited exploit VBN cord-005453-4057qib7 13161 9 to to TO cord-005453-4057qib7 13161 10 treat treat VB cord-005453-4057qib7 13161 11 many many JJ cord-005453-4057qib7 13161 12 kinds kind NNS cord-005453-4057qib7 13161 13 of of IN cord-005453-4057qib7 13161 14 malignancies malignancy NNS cord-005453-4057qib7 13161 15 , , , cord-005453-4057qib7 13161 16 currently currently RB cord-005453-4057qib7 13161 17 its -PRON- PRP$ cord-005453-4057qib7 13161 18 success success NN cord-005453-4057qib7 13161 19 rate rate NN cord-005453-4057qib7 13161 20 in in IN cord-005453-4057qib7 13161 21 GBM GBM NNP cord-005453-4057qib7 13161 22 is be VBZ cord-005453-4057qib7 13161 23 limited limit VBN cord-005453-4057qib7 13161 24 . . . cord-005453-4057qib7 13162 1 Therefore therefore RB cord-005453-4057qib7 13162 2 , , , cord-005453-4057qib7 13162 3 the the DT cord-005453-4057qib7 13162 4 GBM GBM NNP cord-005453-4057qib7 13162 5 treatment treatment NN cord-005453-4057qib7 13162 6 paradigm paradigm NN cord-005453-4057qib7 13162 7 needs need VBZ cord-005453-4057qib7 13162 8 shifting shift VBG cord-005453-4057qib7 13162 9 towards towards IN cord-005453-4057qib7 13162 10 more more JJR cord-005453-4057qib7 13162 11 effective effective JJ cord-005453-4057qib7 13162 12 treatments treatment NNS cord-005453-4057qib7 13162 13 such such JJ cord-005453-4057qib7 13162 14 as as IN cord-005453-4057qib7 13162 15 immune immune JJ cord-005453-4057qib7 13162 16 cell cell NN cord-005453-4057qib7 13162 17 therapy therapy NN cord-005453-4057qib7 13162 18 . . . cord-005453-4057qib7 13163 1 Natural natural JJ cord-005453-4057qib7 13163 2 killer killer NN cord-005453-4057qib7 13163 3 ( ( -LRB- cord-005453-4057qib7 13163 4 NK NK NNP cord-005453-4057qib7 13163 5 ) ) -RRB- cord-005453-4057qib7 13163 6 cells cell NNS cord-005453-4057qib7 13163 7 have have VBP cord-005453-4057qib7 13163 8 been be VBN cord-005453-4057qib7 13163 9 recognized recognize VBN cord-005453-4057qib7 13163 10 as as IN cord-005453-4057qib7 13163 11 potential potential JJ cord-005453-4057qib7 13163 12 anti anti JJ cord-005453-4057qib7 13163 13 - - JJ cord-005453-4057qib7 13163 14 cancer cancer JJ cord-005453-4057qib7 13163 15 effector effector NN cord-005453-4057qib7 13163 16 cells cell NNS cord-005453-4057qib7 13163 17 , , , cord-005453-4057qib7 13163 18 as as IN cord-005453-4057qib7 13163 19 they -PRON- PRP cord-005453-4057qib7 13163 20 can can MD cord-005453-4057qib7 13163 21 recognize recognize VB cord-005453-4057qib7 13163 22 and and CC cord-005453-4057qib7 13163 23 target target VB cord-005453-4057qib7 13163 24 tumor tumor NN cord-005453-4057qib7 13163 25 cells cell NNS cord-005453-4057qib7 13163 26 . . . cord-005453-4057qib7 13164 1 Since since IN cord-005453-4057qib7 13164 2 a a DT cord-005453-4057qib7 13164 3 small small JJ cord-005453-4057qib7 13164 4 percentage percentage NN cord-005453-4057qib7 13164 5 of of IN cord-005453-4057qib7 13164 6 blood blood NN cord-005453-4057qib7 13164 7 cells cell NNS cord-005453-4057qib7 13164 8 are be VBP cord-005453-4057qib7 13164 9 differentiated differentiate VBN cord-005453-4057qib7 13164 10 as as IN cord-005453-4057qib7 13164 11 NK NK NNP cord-005453-4057qib7 13164 12 cells cell NNS cord-005453-4057qib7 13164 13 , , , cord-005453-4057qib7 13164 14 the the DT cord-005453-4057qib7 13164 15 number number NN cord-005453-4057qib7 13164 16 of of IN cord-005453-4057qib7 13164 17 this this DT cord-005453-4057qib7 13164 18 group group NN cord-005453-4057qib7 13164 19 of of IN cord-005453-4057qib7 13164 20 cells cell NNS cord-005453-4057qib7 13164 21 is be VBZ cord-005453-4057qib7 13164 22 hardly hardly RB cord-005453-4057qib7 13164 23 enough enough JJ cord-005453-4057qib7 13164 24 to to TO cord-005453-4057qib7 13164 25 fight fight VB cord-005453-4057qib7 13164 26 tumors tumor NNS cord-005453-4057qib7 13164 27 , , , cord-005453-4057qib7 13164 28 and and CC cord-005453-4057qib7 13164 29 so so RB cord-005453-4057qib7 13164 30 their -PRON- PRP$ cord-005453-4057qib7 13164 31 multiplication multiplication NN cord-005453-4057qib7 13164 32 and and CC cord-005453-4057qib7 13164 33 activation activation NN cord-005453-4057qib7 13164 34 would would MD cord-005453-4057qib7 13164 35 be be VB cord-005453-4057qib7 13164 36 a a DT cord-005453-4057qib7 13164 37 potential potential JJ cord-005453-4057qib7 13164 38 effective effective JJ cord-005453-4057qib7 13164 39 cancer cancer NN cord-005453-4057qib7 13164 40 treatment treatment NN cord-005453-4057qib7 13164 41 . . . cord-005453-4057qib7 13165 1 Methods method NNS cord-005453-4057qib7 13165 2 : : : cord-005453-4057qib7 13166 1 This this DT cord-005453-4057qib7 13166 2 preclinical preclinical JJ cord-005453-4057qib7 13166 3 study study NN cord-005453-4057qib7 13166 4 was be VBD cord-005453-4057qib7 13166 5 focused focus VBN cord-005453-4057qib7 13166 6 on on IN cord-005453-4057qib7 13166 7 setting set VBG cord-005453-4057qib7 13166 8 up up RP cord-005453-4057qib7 13166 9 an an DT cord-005453-4057qib7 13166 10 optimal optimal JJ cord-005453-4057qib7 13166 11 protocol protocol NN cord-005453-4057qib7 13166 12 for for IN cord-005453-4057qib7 13166 13 expansion expansion NN cord-005453-4057qib7 13166 14 and and CC cord-005453-4057qib7 13166 15 activation activation NN cord-005453-4057qib7 13166 16 of of IN cord-005453-4057qib7 13166 17 naïve naïve JJ cord-005453-4057qib7 13166 18 NK NK NNP cord-005453-4057qib7 13166 19 cells cell NNS cord-005453-4057qib7 13166 20 and and CC cord-005453-4057qib7 13166 21 assessing assess VBG cord-005453-4057qib7 13166 22 their -PRON- PRP$ cord-005453-4057qib7 13166 23 efficacy efficacy NN cord-005453-4057qib7 13166 24 towards towards IN cord-005453-4057qib7 13166 25 induced induce VBN cord-005453-4057qib7 13166 26 GBM GBM NNP cord-005453-4057qib7 13166 27 in in IN cord-005453-4057qib7 13166 28 rat rat NN cord-005453-4057qib7 13166 29 models model NNS cord-005453-4057qib7 13166 30 . . . cord-005453-4057qib7 13167 1 Ex Ex NNP cord-005453-4057qib7 13167 2 - - NN cord-005453-4057qib7 13167 3 vivo vivo NNP cord-005453-4057qib7 13167 4 expanded expand VBD cord-005453-4057qib7 13167 5 and and CC cord-005453-4057qib7 13167 6 interlukin-2 interlukin-2 NNP cord-005453-4057qib7 13168 1 ( ( -LRB- cord-005453-4057qib7 13168 2 IL-2)and il-2)and CC cord-005453-4057qib7 13168 3 heat heat NN cord-005453-4057qib7 13168 4 shock shock NN cord-005453-4057qib7 13168 5 protein-70 protein-70 CD cord-005453-4057qib7 13169 1 ( ( -LRB- cord-005453-4057qib7 13169 2 HSP-70)-treated hsp-70)-treated JJ cord-005453-4057qib7 13169 3 NK NK NNP cord-005453-4057qib7 13169 4 cells cell NNS cord-005453-4057qib7 13169 5 have have VBP cord-005453-4057qib7 13169 6 been be VBN cord-005453-4057qib7 13169 7 exploited exploit VBN cord-005453-4057qib7 13169 8 . . . cord-005453-4057qib7 13170 1 After after IN cord-005453-4057qib7 13170 2 in in IN cord-005453-4057qib7 13170 3 vitro vitro FW cord-005453-4057qib7 13170 4 study study NN cord-005453-4057qib7 13170 5 and and CC cord-005453-4057qib7 13170 6 confirming confirm VBG cord-005453-4057qib7 13170 7 the the DT cord-005453-4057qib7 13170 8 efficacy efficacy NN cord-005453-4057qib7 13170 9 of of IN cord-005453-4057qib7 13170 10 treated treat VBN cord-005453-4057qib7 13170 11 cells cell NNS cord-005453-4057qib7 13170 12 through through IN cord-005453-4057qib7 13170 13 cytotoxicity cytotoxicity NN cord-005453-4057qib7 13170 14 assays assay NNS cord-005453-4057qib7 13170 15 , , , cord-005453-4057qib7 13170 16 we -PRON- PRP cord-005453-4057qib7 13170 17 induced induce VBD cord-005453-4057qib7 13170 18 GBM GBM NNP cord-005453-4057qib7 13170 19 in in IN cord-005453-4057qib7 13170 20 6 6 CD cord-005453-4057qib7 13170 21 male male JJ cord-005453-4057qib7 13170 22 Wistar Wistar NNP cord-005453-4057qib7 13170 23 rats rat NNS cord-005453-4057qib7 13170 24 ( ( -LRB- cord-005453-4057qib7 13170 25 weighted weight VBD cord-005453-4057qib7 13170 26 275 275 CD cord-005453-4057qib7 13170 27 - - SYM cord-005453-4057qib7 13170 28 300 300 CD cord-005453-4057qib7 13170 29 gr gr NN cord-005453-4057qib7 13170 30 ) ) -RRB- cord-005453-4057qib7 13170 31 using use VBG cord-005453-4057qib7 13170 32 C6 C6 NNP cord-005453-4057qib7 13170 33 tumor tumor NN cord-005453-4057qib7 13170 34 cells cell NNS cord-005453-4057qib7 13170 35 injection injection NN cord-005453-4057qib7 13170 36 in in IN cord-005453-4057qib7 13170 37 rat rat NN cord-005453-4057qib7 13170 38 brain brain NN cord-005453-4057qib7 13170 39 through through IN cord-005453-4057qib7 13170 40 stereotactic stereotactic JJ cord-005453-4057qib7 13170 41 surgery surgery NN cord-005453-4057qib7 13170 42 . . . cord-005453-4057qib7 13171 1 The the DT cord-005453-4057qib7 13171 2 tumor tumor NN cord-005453-4057qib7 13171 3 formation formation NN cord-005453-4057qib7 13171 4 was be VBD cord-005453-4057qib7 13171 5 proven prove VBN cord-005453-4057qib7 13171 6 by by IN cord-005453-4057qib7 13171 7 MRI MRI NNP cord-005453-4057qib7 13171 8 imaging imaging NN cord-005453-4057qib7 13171 9 . . . cord-005453-4057qib7 13172 1 Following follow VBG cord-005453-4057qib7 13172 2 tumor tumor NN cord-005453-4057qib7 13172 3 establishment establishment NN cord-005453-4057qib7 13172 4 , , , cord-005453-4057qib7 13172 5 we -PRON- PRP cord-005453-4057qib7 13172 6 analyzed analyze VBD cord-005453-4057qib7 13172 7 the the DT cord-005453-4057qib7 13172 8 effect effect NN cord-005453-4057qib7 13172 9 of of IN cord-005453-4057qib7 13172 10 single single JJ cord-005453-4057qib7 13172 11 injection injection NN cord-005453-4057qib7 13172 12 of of IN cord-005453-4057qib7 13172 13 IL-2-and IL-2-and NNP cord-005453-4057qib7 13172 14 HSP-70-treated HSP-70-treated NNP cord-005453-4057qib7 13172 15 NK NK NNP cord-005453-4057qib7 13172 16 cells cell NNS cord-005453-4057qib7 13172 17 compared compare VBN cord-005453-4057qib7 13172 18 with with IN cord-005453-4057qib7 13172 19 single single JJ cord-005453-4057qib7 13172 20 injection injection NN cord-005453-4057qib7 13172 21 of of IN cord-005453-4057qib7 13172 22 non non JJ cord-005453-4057qib7 13172 23 - - JJ cord-005453-4057qib7 13172 24 treated treated JJ cord-005453-4057qib7 13172 25 NK NK NNP cord-005453-4057qib7 13172 26 cells cell NNS cord-005453-4057qib7 13172 27 in in IN cord-005453-4057qib7 13172 28 two two CD cord-005453-4057qib7 13172 29 groups group NNS cord-005453-4057qib7 13172 30 of of IN cord-005453-4057qib7 13172 31 rats rat NNS cord-005453-4057qib7 13172 32 . . . cord-005453-4057qib7 13173 1 Results result NNS cord-005453-4057qib7 13173 2 : : : cord-005453-4057qib7 13174 1 Systemic systemic JJ cord-005453-4057qib7 13174 2 intravenous intravenous JJ cord-005453-4057qib7 13174 3 delivery delivery NN cord-005453-4057qib7 13174 4 of of IN cord-005453-4057qib7 13174 5 IL-2-and IL-2-and NNP cord-005453-4057qib7 13174 6 HSP-70-treated HSP-70-treated NNP cord-005453-4057qib7 13174 7 NK NK NNP cord-005453-4057qib7 13174 8 cells cell NNS cord-005453-4057qib7 13174 9 through through IN cord-005453-4057qib7 13174 10 tail tail NN cord-005453-4057qib7 13174 11 's 's POS cord-005453-4057qib7 13174 12 vein vein NN cord-005453-4057qib7 13174 13 resulted result VBD cord-005453-4057qib7 13174 14 in in IN cord-005453-4057qib7 13174 15 tumor tumor NN cord-005453-4057qib7 13174 16 shrinkage shrinkage NN cord-005453-4057qib7 13174 17 in in IN cord-005453-4057qib7 13174 18 different different JJ cord-005453-4057qib7 13174 19 time time NN cord-005453-4057qib7 13174 20 intervals interval NNS cord-005453-4057qib7 13174 21 and and CC cord-005453-4057qib7 13174 22 complete complete VB cord-005453-4057qib7 13174 23 remission remission NN cord-005453-4057qib7 13174 24 in in IN cord-005453-4057qib7 13174 25 the the DT cord-005453-4057qib7 13174 26 first first JJ cord-005453-4057qib7 13174 27 group group NN cord-005453-4057qib7 13174 28 of of IN cord-005453-4057qib7 13174 29 GBM GBM NNP cord-005453-4057qib7 13174 30 - - HYPH cord-005453-4057qib7 13174 31 induced induce VBN cord-005453-4057qib7 13174 32 rat rat NN cord-005453-4057qib7 13174 33 models model NNS cord-005453-4057qib7 13174 34 , , , cord-005453-4057qib7 13174 35 whereas whereas IN cord-005453-4057qib7 13174 36 in in IN cord-005453-4057qib7 13174 37 the the DT cord-005453-4057qib7 13174 38 other other JJ cord-005453-4057qib7 13174 39 group group NN cord-005453-4057qib7 13174 40 of of IN cord-005453-4057qib7 13174 41 GBM GBM NNP cord-005453-4057qib7 13174 42 rats rat NNS cord-005453-4057qib7 13174 43 receiving receive VBG cord-005453-4057qib7 13174 44 untreated untreated JJ cord-005453-4057qib7 13174 45 NK NK NNP cord-005453-4057qib7 13174 46 cells cell NNS cord-005453-4057qib7 13174 47 , , , cord-005453-4057qib7 13174 48 the the DT cord-005453-4057qib7 13174 49 tumor tumor NN cord-005453-4057qib7 13174 50 progressed progress VBD cord-005453-4057qib7 13174 51 . . . cord-005453-4057qib7 13175 1 Therapeutic therapeutic JJ cord-005453-4057qib7 13175 2 efficacy efficacy NN cord-005453-4057qib7 13175 3 of of IN cord-005453-4057qib7 13175 4 the the DT cord-005453-4057qib7 13175 5 treated treat VBN cord-005453-4057qib7 13175 6 NK NK NNP cord-005453-4057qib7 13175 7 cells cell NNS cord-005453-4057qib7 13175 8 was be VBD cord-005453-4057qib7 13175 9 ascertained ascertain VBN cord-005453-4057qib7 13175 10 compared compare VBN cord-005453-4057qib7 13175 11 with with IN cord-005453-4057qib7 13175 12 non non JJ cord-005453-4057qib7 13175 13 - - JJ cord-005453-4057qib7 13175 14 treated treated JJ cord-005453-4057qib7 13175 15 NK NK NNP cord-005453-4057qib7 13175 16 cells cell NNS cord-005453-4057qib7 13175 17 considering consider VBG cord-005453-4057qib7 13175 18 tumor tumor NN cord-005453-4057qib7 13175 19 shrinkage shrinkage NN cord-005453-4057qib7 13175 20 observed observe VBN cord-005453-4057qib7 13175 21 in in IN cord-005453-4057qib7 13175 22 MRI MRI NNP cord-005453-4057qib7 13175 23 and and CC cord-005453-4057qib7 13175 24 survival survival NN cord-005453-4057qib7 13175 25 rates rate NNS cord-005453-4057qib7 13175 26 between between IN cord-005453-4057qib7 13175 27 the the DT cord-005453-4057qib7 13175 28 two two CD cord-005453-4057qib7 13175 29 model model NN cord-005453-4057qib7 13175 30 groups group NNS cord-005453-4057qib7 13175 31 . . . cord-005453-4057qib7 13176 1 Conclusions conclusion NNS cord-005453-4057qib7 13176 2 : : : cord-005453-4057qib7 13177 1 The the DT cord-005453-4057qib7 13177 2 amelioration amelioration NN cord-005453-4057qib7 13177 3 of of IN cord-005453-4057qib7 13177 4 tumor tumor NN cord-005453-4057qib7 13177 5 which which WDT cord-005453-4057qib7 13177 6 has have VBZ cord-005453-4057qib7 13177 7 been be VBN cord-005453-4057qib7 13177 8 confirmed confirm VBN cord-005453-4057qib7 13177 9 by by IN cord-005453-4057qib7 13177 10 MRI MRI NNP cord-005453-4057qib7 13177 11 , , , cord-005453-4057qib7 13177 12 proved prove VBD cord-005453-4057qib7 13177 13 the the DT cord-005453-4057qib7 13177 14 migration migration NN cord-005453-4057qib7 13177 15 of of IN cord-005453-4057qib7 13177 16 activated activate VBN cord-005453-4057qib7 13177 17 NK NK NNP cord-005453-4057qib7 13177 18 cells cell NNS cord-005453-4057qib7 13177 19 through through IN cord-005453-4057qib7 13177 20 blood blood NN cord-005453-4057qib7 13177 21 brain brain NN cord-005453-4057qib7 13177 22 barrier barrier NN cord-005453-4057qib7 13177 23 and and CC cord-005453-4057qib7 13177 24 homing homing NN cord-005453-4057qib7 13177 25 to to IN cord-005453-4057qib7 13177 26 CNS CNS NNP cord-005453-4057qib7 13177 27 , , , cord-005453-4057qib7 13177 28 and and CC cord-005453-4057qib7 13177 29 finally finally RB cord-005453-4057qib7 13177 30 targeting target VBG cord-005453-4057qib7 13177 31 GBM GBM NNP cord-005453-4057qib7 13177 32 tumor tumor NN cord-005453-4057qib7 13177 33 cells cell NNS cord-005453-4057qib7 13177 34 . . . cord-005453-4057qib7 13178 1 Our -PRON- PRP$ cord-005453-4057qib7 13178 2 data datum NNS cord-005453-4057qib7 13178 3 suggest suggest VBP cord-005453-4057qib7 13178 4 that that IN cord-005453-4057qib7 13178 5 NK NK NNP cord-005453-4057qib7 13178 6 - - HYPH cord-005453-4057qib7 13178 7 cells cell NNS cord-005453-4057qib7 13178 8 treated treat VBN cord-005453-4057qib7 13178 9 with with IN cord-005453-4057qib7 13178 10 IL2 IL2 NNP cord-005453-4057qib7 13178 11 / / SYM cord-005453-4057qib7 13178 12 HSP70 HSP70 NNP cord-005453-4057qib7 13178 13 may may MD cord-005453-4057qib7 13178 14 be be VB cord-005453-4057qib7 13178 15 a a DT cord-005453-4057qib7 13178 16 promising promising JJ cord-005453-4057qib7 13178 17 immune immune JJ cord-005453-4057qib7 13178 18 cell cell NN cord-005453-4057qib7 13178 19 - - HYPH cord-005453-4057qib7 13178 20 based base VBN cord-005453-4057qib7 13178 21 therapeutic therapeutic JJ cord-005453-4057qib7 13178 22 approach approach NN cord-005453-4057qib7 13178 23 towards towards IN cord-005453-4057qib7 13178 24 treating treat VBG cord-005453-4057qib7 13178 25 the the DT cord-005453-4057qib7 13178 26 fatal fatal JJ cord-005453-4057qib7 13178 27 GBM GBM NNP cord-005453-4057qib7 13178 28 . . . cord-005453-4057qib7 13179 1 Disclosure disclosure NN cord-005453-4057qib7 13179 2 : : : cord-005453-4057qib7 13179 3 Nothing nothing NN cord-005453-4057qib7 13179 4 to to TO cord-005453-4057qib7 13179 5 declare declare VB cord-005453-4057qib7 13179 6 P592 P592 NNP cord-005453-4057qib7 13179 7 Abstract Abstract NNP cord-005453-4057qib7 13179 8 withdrawn withdraw VBN cord-005453-4057qib7 13179 9 . . . cord-005453-4057qib7 13180 1 Long long JJ cord-005453-4057qib7 13180 2 term term NN cord-005453-4057qib7 13180 3 sorafenib sorafenib NN cord-005453-4057qib7 13180 4 response response NN cord-005453-4057qib7 13180 5 for for IN cord-005453-4057qib7 13180 6 extramedullary extramedullary NNP cord-005453-4057qib7 13181 1 FLT3 FLT3 NNP cord-005453-4057qib7 13181 2 + + CC cord-005453-4057qib7 13181 3 AML AML NNP cord-005453-4057qib7 13181 4 relapse relapse NN cord-005453-4057qib7 13181 5 after after IN cord-005453-4057qib7 13181 6 allogeneic allogeneic NN cord-005453-4057qib7 13181 7 stem stem NN cord-005453-4057qib7 13181 8 cell cell NN cord-005453-4057qib7 13181 9 transplantation transplantation NN cord-005453-4057qib7 13181 10 Since since IN cord-005453-4057qib7 13181 11 June June NNP cord-005453-4057qib7 13181 12 2017 2017 CD cord-005453-4057qib7 13181 13 , , , cord-005453-4057qib7 13181 14 Sorafenib Sorafenib NNP cord-005453-4057qib7 13181 15 dose dose NN cord-005453-4057qib7 13181 16 has have VBZ cord-005453-4057qib7 13181 17 been be VBN cord-005453-4057qib7 13181 18 tapered taper VBN cord-005453-4057qib7 13181 19 to to IN cord-005453-4057qib7 13181 20 200 200 CD cord-005453-4057qib7 13181 21 mg mg NNP cord-005453-4057qib7 13181 22 / / SYM cord-005453-4057qib7 13181 23 day day NN cord-005453-4057qib7 13181 24 , , , cord-005453-4057qib7 13181 25 due due JJ cord-005453-4057qib7 13181 26 to to IN cord-005453-4057qib7 13181 27 mild mild JJ cord-005453-4057qib7 13181 28 skin skin NN cord-005453-4057qib7 13181 29 and and CC cord-005453-4057qib7 13181 30 GI gi NN cord-005453-4057qib7 13181 31 toxicity toxicity NN cord-005453-4057qib7 13181 32 . . . cord-005453-4057qib7 13182 1 After after IN cord-005453-4057qib7 13182 2 3 3 CD cord-005453-4057qib7 13182 3 years year NNS cord-005453-4057qib7 13182 4 of of IN cord-005453-4057qib7 13182 5 treatment treatment NN cord-005453-4057qib7 13182 6 , , , cord-005453-4057qib7 13182 7 she -PRON- PRP cord-005453-4057qib7 13182 8 maintains maintain VBZ cord-005453-4057qib7 13182 9 CR CR NNP cord-005453-4057qib7 13182 10 at at IN cord-005453-4057qib7 13182 11 medullary medullary JJ cord-005453-4057qib7 13182 12 and and CC cord-005453-4057qib7 13182 13 extramedulary extramedulary JJ cord-005453-4057qib7 13182 14 levels level NNS cord-005453-4057qib7 13182 15 , , , cord-005453-4057qib7 13182 16 with with IN cord-005453-4057qib7 13182 17 no no DT cord-005453-4057qib7 13182 18 evidence evidence NN cord-005453-4057qib7 13182 19 of of IN cord-005453-4057qib7 13182 20 a a DT cord-005453-4057qib7 13182 21 disease disease NN cord-005453-4057qib7 13182 22 that that WDT cord-005453-4057qib7 13182 23 had have VBD cord-005453-4057qib7 13182 24 escaped escape VBN cord-005453-4057qib7 13182 25 the the DT cord-005453-4057qib7 13182 26 mechanisms mechanism NNS cord-005453-4057qib7 13182 27 of of IN cord-005453-4057qib7 13182 28 action action NN cord-005453-4057qib7 13182 29 of of IN cord-005453-4057qib7 13182 30 chemo chemo NN cord-005453-4057qib7 13182 31 , , , cord-005453-4057qib7 13182 32 HSCT HSCT NNP cord-005453-4057qib7 13182 33 and and CC cord-005453-4057qib7 13182 34 DLI DLI NNP cord-005453-4057qib7 13182 35 . . . cord-005453-4057qib7 13183 1 Conclusions conclusion NNS cord-005453-4057qib7 13183 2 : : : cord-005453-4057qib7 13184 1 In in IN cord-005453-4057qib7 13184 2 our -PRON- PRP$ cord-005453-4057qib7 13184 3 patient patient NN cord-005453-4057qib7 13184 4 , , , cord-005453-4057qib7 13184 5 treatment treatment NN cord-005453-4057qib7 13184 6 with with IN cord-005453-4057qib7 13184 7 Sorafenib Sorafenib NNP cord-005453-4057qib7 13184 8 has have VBZ cord-005453-4057qib7 13184 9 provided provide VBN cord-005453-4057qib7 13184 10 long long JJ cord-005453-4057qib7 13184 11 - - HYPH cord-005453-4057qib7 13184 12 term term NN cord-005453-4057qib7 13184 13 control control NN cord-005453-4057qib7 13184 14 of of IN cord-005453-4057qib7 13184 15 this this DT cord-005453-4057qib7 13184 16 refractory refractory JJ cord-005453-4057qib7 13184 17 extramedullary extramedullary JJ cord-005453-4057qib7 13184 18 disease disease NN cord-005453-4057qib7 13184 19 , , , cord-005453-4057qib7 13184 20 even even RB cord-005453-4057qib7 13184 21 at at IN cord-005453-4057qib7 13184 22 adjusted adjust VBN cord-005453-4057qib7 13184 23 doses dose NNS cord-005453-4057qib7 13184 24 . . . cord-005453-4057qib7 13185 1 Further further JJ cord-005453-4057qib7 13185 2 studies study NNS cord-005453-4057qib7 13185 3 are be VBP cord-005453-4057qib7 13185 4 needed need VBN cord-005453-4057qib7 13185 5 to to TO cord-005453-4057qib7 13185 6 confirm confirm VB cord-005453-4057qib7 13185 7 the the DT cord-005453-4057qib7 13185 8 efficacy efficacy NN cord-005453-4057qib7 13185 9 of of IN cord-005453-4057qib7 13185 10 FLT3 FLT3 NNP cord-005453-4057qib7 13185 11 inhibitors inhibitor NNS cord-005453-4057qib7 13185 12 in in IN cord-005453-4057qib7 13185 13 the the DT cord-005453-4057qib7 13185 14 control control NN cord-005453-4057qib7 13185 15 of of IN cord-005453-4057qib7 13185 16 relapses relapse NNS cord-005453-4057qib7 13185 17 after after IN cord-005453-4057qib7 13185 18 allo allo NN cord-005453-4057qib7 13185 19 - - HYPH cord-005453-4057qib7 13185 20 HSCT HSCT NNP cord-005453-4057qib7 13185 21 , , , cord-005453-4057qib7 13185 22 extramedullary extramedullary JJ cord-005453-4057qib7 13185 23 disease disease NN cord-005453-4057qib7 13185 24 and and CC cord-005453-4057qib7 13185 25 its -PRON- PRP$ cord-005453-4057qib7 13185 26 potential potential JJ cord-005453-4057qib7 13185 27 role role NN cord-005453-4057qib7 13185 28 as as IN cord-005453-4057qib7 13185 29 maintenance maintenance NN cord-005453-4057qib7 13185 30 agent agent NN cord-005453-4057qib7 13185 31 . . . cord-005453-4057qib7 13186 1 Disclosure disclosure NN cord-005453-4057qib7 13186 2 : : : cord-005453-4057qib7 13186 3 Nothing nothing NN cord-005453-4057qib7 13186 4 to to TO cord-005453-4057qib7 13186 5 declare declare VB cord-005453-4057qib7 13186 6 Background background NN cord-005453-4057qib7 13186 7 : : : cord-005453-4057qib7 13187 1 Although although IN cord-005453-4057qib7 13187 2 chemotherapeutic(CT chemotherapeutic(CT NNP cord-005453-4057qib7 13187 3 ) ) -RRB- cord-005453-4057qib7 13187 4 agents agent NNS cord-005453-4057qib7 13187 5 that that WDT cord-005453-4057qib7 13187 6 used use VBD cord-005453-4057qib7 13187 7 in in IN cord-005453-4057qib7 13187 8 the the DT cord-005453-4057qib7 13187 9 treatment treatment NN cord-005453-4057qib7 13187 10 of of IN cord-005453-4057qib7 13187 11 acute acute JJ cord-005453-4057qib7 13187 12 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13187 13 leukemia leukemia NN cord-005453-4057qib7 13187 14 ( ( -LRB- cord-005453-4057qib7 13187 15 ALL all DT cord-005453-4057qib7 13187 16 ) ) -RRB- cord-005453-4057qib7 13187 17 increase increase VB cord-005453-4057qib7 13187 18 survival survival NN cord-005453-4057qib7 13187 19 , , , cord-005453-4057qib7 13187 20 the the DT cord-005453-4057qib7 13187 21 results result NNS cord-005453-4057qib7 13187 22 are be VBP cord-005453-4057qib7 13187 23 still still RB cord-005453-4057qib7 13187 24 weak weak JJ cord-005453-4057qib7 13187 25 . . . cord-005453-4057qib7 13188 1 Longterm longterm JJ cord-005453-4057qib7 13188 2 survival survival NN cord-005453-4057qib7 13188 3 with with IN cord-005453-4057qib7 13188 4 CT CT NNP cord-005453-4057qib7 13188 5 's 's POS cord-005453-4057qib7 13188 6 in in IN cord-005453-4057qib7 13188 7 relapse relapse NN cord-005453-4057qib7 13189 1 ALL all DT cord-005453-4057qib7 13189 2 cases case NNS cord-005453-4057qib7 13189 3 is be VBZ cord-005453-4057qib7 13189 4 difficult difficult JJ cord-005453-4057qib7 13189 5 and and CC cord-005453-4057qib7 13189 6 the the DT cord-005453-4057qib7 13189 7 prognosis prognosis NN cord-005453-4057qib7 13189 8 is be VBZ cord-005453-4057qib7 13189 9 very very RB cord-005453-4057qib7 13189 10 weak weak JJ cord-005453-4057qib7 13189 11 . . . cord-005453-4057qib7 13190 1 Inotuzumab inotuzumab JJ cord-005453-4057qib7 13190 2 ozogamicin ozogamicin NN cord-005453-4057qib7 13190 3 is be VBZ cord-005453-4057qib7 13190 4 an an DT cord-005453-4057qib7 13190 5 anti anti JJ cord-005453-4057qib7 13190 6 - - JJ cord-005453-4057qib7 13190 7 CD cd JJ cord-005453-4057qib7 13190 8 22 22 CD cord-005453-4057qib7 13190 9 monoclonal monoclonal JJ cord-005453-4057qib7 13190 10 antibody antibody NN cord-005453-4057qib7 13190 11 and and CC cord-005453-4057qib7 13190 12 it -PRON- PRP cord-005453-4057qib7 13190 13 has have VBZ cord-005453-4057qib7 13190 14 the the DT cord-005453-4057qib7 13190 15 potential potential NN cord-005453-4057qib7 13190 16 to to TO cord-005453-4057qib7 13190 17 reduce reduce VB cord-005453-4057qib7 13190 18 the the DT cord-005453-4057qib7 13190 19 overall overall JJ cord-005453-4057qib7 13190 20 toxicity toxicity NN cord-005453-4057qib7 13190 21 of of IN cord-005453-4057qib7 13190 22 intensive intensive JJ cord-005453-4057qib7 13190 23 regimens regimen NNS cord-005453-4057qib7 13190 24 for for IN cord-005453-4057qib7 13190 25 ALL all DT cord-005453-4057qib7 13190 26 , , , cord-005453-4057qib7 13190 27 as as RB cord-005453-4057qib7 13190 28 well well RB cord-005453-4057qib7 13190 29 as as IN cord-005453-4057qib7 13190 30 to to TO cord-005453-4057qib7 13190 31 possibly possibly RB cord-005453-4057qib7 13190 32 increase increase VB cord-005453-4057qib7 13190 33 the the DT cord-005453-4057qib7 13190 34 number number NN cord-005453-4057qib7 13190 35 of of IN cord-005453-4057qib7 13190 36 patients patient NNS cord-005453-4057qib7 13190 37 who who WP cord-005453-4057qib7 13190 38 may may MD cord-005453-4057qib7 13190 39 achieve achieve VB cord-005453-4057qib7 13190 40 a a DT cord-005453-4057qib7 13190 41 state state NN cord-005453-4057qib7 13190 42 of of IN cord-005453-4057qib7 13190 43 minimal minimal JJ cord-005453-4057qib7 13190 44 residual residual JJ cord-005453-4057qib7 13190 45 disease disease NN cord-005453-4057qib7 13190 46 . . . cord-005453-4057qib7 13191 1 Methods method NNS cord-005453-4057qib7 13191 2 : : : cord-005453-4057qib7 13192 1 26-year 26-year JJ cord-005453-4057qib7 13192 2 - - HYPH cord-005453-4057qib7 13192 3 old old JJ cord-005453-4057qib7 13192 4 male male JJ cord-005453-4057qib7 13192 5 patient patient NN cord-005453-4057qib7 13192 6 was be VBD cord-005453-4057qib7 13192 7 diagnosed diagnose VBN cord-005453-4057qib7 13192 8 with with IN cord-005453-4057qib7 13192 9 B b NN cord-005453-4057qib7 13192 10 - - HYPH cord-005453-4057qib7 13192 11 cell cell NN cord-005453-4057qib7 13192 12 ALL all DT cord-005453-4057qib7 13192 13 in in IN cord-005453-4057qib7 13192 14 December December NNP cord-005453-4057qib7 13192 15 2017.After 2017.after CD cord-005453-4057qib7 13193 1 the the DT cord-005453-4057qib7 13193 2 HOELZER HOELZER NNP cord-005453-4057qib7 13193 3 KT KT NNP cord-005453-4057qib7 13193 4 protocol protocol NN cord-005453-4057qib7 13193 5 was be VBD cord-005453-4057qib7 13193 6 started start VBN cord-005453-4057qib7 13193 7 , , , cord-005453-4057qib7 13193 8 maintenance maintenance NN cord-005453-4057qib7 13193 9 treatment treatment NN cord-005453-4057qib7 13193 10 was be VBD cord-005453-4057qib7 13193 11 continued continue VBN cord-005453-4057qib7 13193 12 . . . cord-005453-4057qib7 13194 1 In in IN cord-005453-4057qib7 13194 2 the the DT cord-005453-4057qib7 13194 3 fifth fifth JJ cord-005453-4057qib7 13194 4 month month NN cord-005453-4057qib7 13194 5 of of IN cord-005453-4057qib7 13194 6 treatment treatment NN cord-005453-4057qib7 13194 7 , , , cord-005453-4057qib7 13194 8 FLAG FLAG NNP cord-005453-4057qib7 13194 9 CT CT NNP cord-005453-4057qib7 13194 10 protocol protocol NN cord-005453-4057qib7 13194 11 was be VBD cord-005453-4057qib7 13194 12 started start VBN cord-005453-4057qib7 13194 13 cause cause NN cord-005453-4057qib7 13194 14 of of IN cord-005453-4057qib7 13194 15 recurrence recurrence NN cord-005453-4057qib7 13194 16 was be VBD cord-005453-4057qib7 13194 17 seen see VBN cord-005453-4057qib7 13194 18 on on IN cord-005453-4057qib7 13194 19 5 5 CD cord-005453-4057qib7 13194 20 % % NN cord-005453-4057qib7 13194 21 blast blast NN cord-005453-4057qib7 13194 22 detection detection NN cord-005453-4057qib7 13194 23 in in IN cord-005453-4057qib7 13194 24 peripheral peripheral JJ cord-005453-4057qib7 13194 25 blood blood NN cord-005453-4057qib7 13194 26 smear smear NN cord-005453-4057qib7 13194 27 . . . cord-005453-4057qib7 13195 1 In in IN cord-005453-4057qib7 13195 2 August August NNP cord-005453-4057qib7 13195 3 2018 2018 CD cord-005453-4057qib7 13195 4 , , , cord-005453-4057qib7 13195 5 inotuzumab inotuzumab NNS cord-005453-4057qib7 13195 6 ozogamicin ozogamicin NNP cord-005453-4057qib7 13195 7 treatment treatment NN cord-005453-4057qib7 13195 8 was be VBD cord-005453-4057qib7 13195 9 started start VBN cord-005453-4057qib7 13195 10 and and CC cord-005453-4057qib7 13195 11 six six CD cord-005453-4057qib7 13195 12 cures cure NNS cord-005453-4057qib7 13195 13 were be VBD cord-005453-4057qib7 13195 14 completed complete VBN cord-005453-4057qib7 13195 15 because because IN cord-005453-4057qib7 13195 16 the the DT cord-005453-4057qib7 13195 17 patient patient NN cord-005453-4057qib7 13195 18 was be VBD cord-005453-4057qib7 13195 19 not not RB cord-005453-4057qib7 13195 20 in in IN cord-005453-4057qib7 13195 21 remission remission NN cord-005453-4057qib7 13195 22 . . . cord-005453-4057qib7 13196 1 In in IN cord-005453-4057qib7 13196 2 September September NNP cord-005453-4057qib7 13196 3 2018 2018 CD cord-005453-4057qib7 13196 4 , , , cord-005453-4057qib7 13196 5 He -PRON- PRP cord-005453-4057qib7 13196 6 had have VBD cord-005453-4057qib7 13196 7 gone go VBN cord-005453-4057qib7 13196 8 Haploidentical Haploidentical NNP cord-005453-4057qib7 13196 9 bone bone NN cord-005453-4057qib7 13196 10 marrow marrow NN cord-005453-4057qib7 13196 11 transplantation transplantation NN cord-005453-4057qib7 13196 12 from from IN cord-005453-4057qib7 13196 13 his -PRON- PRP$ cord-005453-4057qib7 13196 14 sibling sibling NN cord-005453-4057qib7 13196 15 donor(8/10)with donor(8/10)with XX cord-005453-4057qib7 13197 1 Defibrotid Defibrotid NNP cord-005453-4057qib7 13197 2 prophylaxis prophylaxis NN cord-005453-4057qib7 13197 3 for for IN cord-005453-4057qib7 13197 4 Veno Veno NNP cord-005453-4057qib7 13197 5 - - HYPH cord-005453-4057qib7 13197 6 Occlusive Occlusive NNP cord-005453-4057qib7 13197 7 Disease(VOD)s Disease(VOD)s NNP cord-005453-4057qib7 13197 8 . . . cord-005453-4057qib7 13198 1 He -PRON- PRP cord-005453-4057qib7 13198 2 engrafted engraft VBD cord-005453-4057qib7 13198 3 succesfully succesfully RB cord-005453-4057qib7 13198 4 and and CC cord-005453-4057qib7 13198 5 chimerizm chimerizm NNP cord-005453-4057qib7 13198 6 was be VBD cord-005453-4057qib7 13198 7 99.85 99.85 CD cord-005453-4057qib7 13198 8 % % NN cord-005453-4057qib7 13198 9 in in IN cord-005453-4057qib7 13198 10 30th 30th JJ cord-005453-4057qib7 13198 11 days day NNS cord-005453-4057qib7 13198 12 of of IN cord-005453-4057qib7 13198 13 transplantation transplantation NN cord-005453-4057qib7 13198 14 . . . cord-005453-4057qib7 13199 1 He -PRON- PRP cord-005453-4057qib7 13199 2 is be VBZ cord-005453-4057qib7 13199 3 60th 60th JJ cord-005453-4057qib7 13199 4 day day NN cord-005453-4057qib7 13199 5 of of IN cord-005453-4057qib7 13199 6 transplantation transplantation NN cord-005453-4057qib7 13199 7 and and CC cord-005453-4057qib7 13199 8 in in IN cord-005453-4057qib7 13199 9 a a DT cord-005453-4057qib7 13199 10 remission remission NN cord-005453-4057qib7 13199 11 . . . cord-005453-4057qib7 13200 1 Results result NNS cord-005453-4057qib7 13200 2 : : : cord-005453-4057qib7 13201 1 Bone bone NN cord-005453-4057qib7 13201 2 marrow marrow NN cord-005453-4057qib7 13201 3 transplantation transplantation NN cord-005453-4057qib7 13201 4 can can MD cord-005453-4057qib7 13201 5 not not RB cord-005453-4057qib7 13201 6 be be VB cord-005453-4057qib7 13201 7 performed perform VBN cord-005453-4057qib7 13201 8 since since IN cord-005453-4057qib7 13201 9 the the DT cord-005453-4057qib7 13201 10 complete complete JJ cord-005453-4057qib7 13201 11 response response NN cord-005453-4057qib7 13201 12 can can MD cord-005453-4057qib7 13201 13 not not RB cord-005453-4057qib7 13201 14 be be VB cord-005453-4057qib7 13201 15 achieved achieve VBN cord-005453-4057qib7 13201 16 in in IN cord-005453-4057qib7 13201 17 patients patient NNS cord-005453-4057qib7 13201 18 with with IN cord-005453-4057qib7 13201 19 relapse relapse NN cord-005453-4057qib7 13201 20 and and CC cord-005453-4057qib7 13201 21 resistant resistant JJ cord-005453-4057qib7 13201 22 B b NN cord-005453-4057qib7 13201 23 - - HYPH cord-005453-4057qib7 13201 24 ALL.In all.in VB cord-005453-4057qib7 13201 25 these these DT cord-005453-4057qib7 13201 26 patients patient NNS cord-005453-4057qib7 13201 27 , , , cord-005453-4057qib7 13201 28 new new JJ cord-005453-4057qib7 13201 29 therapies therapy NNS cord-005453-4057qib7 13201 30 targeting target VBG cord-005453-4057qib7 13201 31 malignant malignant JJ cord-005453-4057qib7 13201 32 lymphoblasts lymphoblast NNS cord-005453-4057qib7 13201 33 are be VBP cord-005453-4057qib7 13201 34 needed need VBN cord-005453-4057qib7 13201 35 . . . cord-005453-4057qib7 13202 1 Inotuzumab Inotuzumab NNP cord-005453-4057qib7 13202 2 ozogamicinis ozogamicinis VBP cord-005453-4057qib7 13202 3 a a DT cord-005453-4057qib7 13202 4 monoclonal monoclonal JJ cord-005453-4057qib7 13202 5 antibody antibody NN cord-005453-4057qib7 13202 6 drug drug NN cord-005453-4057qib7 13202 7 conjugate conjugate NN cord-005453-4057qib7 13202 8 that that WDT cord-005453-4057qib7 13202 9 targets target VBZ cord-005453-4057qib7 13202 10 CD22 CD22 NNP cord-005453-4057qib7 13202 11 antigen antigen NN cord-005453-4057qib7 13202 12 on on IN cord-005453-4057qib7 13202 13 malignant malignant JJ cord-005453-4057qib7 13202 14 lymphoblasts lymphoblast NNS cord-005453-4057qib7 13202 15 . . . cord-005453-4057qib7 13203 1 In in IN cord-005453-4057qib7 13203 2 many many JJ cord-005453-4057qib7 13203 3 studies study NNS cord-005453-4057qib7 13203 4 , , , cord-005453-4057qib7 13203 5 it -PRON- PRP cord-005453-4057qib7 13203 6 has have VBZ cord-005453-4057qib7 13203 7 been be VBN cord-005453-4057qib7 13203 8 shown show VBN cord-005453-4057qib7 13203 9 that that IN cord-005453-4057qib7 13203 10 Inotuzumab Inotuzumab NNP cord-005453-4057qib7 13203 11 ozogamycin ozogamycin NN cord-005453-4057qib7 13203 12 is be VBZ cord-005453-4057qib7 13203 13 effective effective JJ cord-005453-4057qib7 13203 14 and and CC cord-005453-4057qib7 13203 15 reliable reliable JJ cord-005453-4057qib7 13203 16 anti anti JJ cord-005453-4057qib7 13203 17 - - JJ cord-005453-4057qib7 13203 18 tumor tumor JJ cord-005453-4057qib7 13203 19 activity activity NN cord-005453-4057qib7 13203 20 in in IN cord-005453-4057qib7 13203 21 adults adult NNS cord-005453-4057qib7 13203 22 with with IN cord-005453-4057qib7 13203 23 recurrent recurrent JJ cord-005453-4057qib7 13203 24 and and CC cord-005453-4057qib7 13203 25 resistant resistant JJ cord-005453-4057qib7 13203 26 CD22 CD22 NNP cord-005453-4057qib7 13203 27 positive positive JJ cord-005453-4057qib7 13203 28 ALL all DT cord-005453-4057qib7 13203 29 . . . cord-005453-4057qib7 13204 1 However however RB cord-005453-4057qib7 13204 2 , , , cord-005453-4057qib7 13204 3 monoclonal monoclonal JJ cord-005453-4057qib7 13204 4 antibody antibody NN cord-005453-4057qib7 13204 5 drug drug NN cord-005453-4057qib7 13204 6 conjugates conjugate NNS cord-005453-4057qib7 13204 7 have have VBP cord-005453-4057qib7 13204 8 been be VBN cord-005453-4057qib7 13204 9 shown show VBN cord-005453-4057qib7 13204 10 to to TO cord-005453-4057qib7 13204 11 be be VB cord-005453-4057qib7 13204 12 associated associate VBN cord-005453-4057qib7 13204 13 with with IN cord-005453-4057qib7 13204 14 VOD VOD NNP cord-005453-4057qib7 13204 15 's 's POS cord-005453-4057qib7 13204 16 . . . cord-005453-4057qib7 13205 1 For for IN cord-005453-4057qib7 13205 2 this this DT cord-005453-4057qib7 13205 3 purpose purpose NN cord-005453-4057qib7 13205 4 , , , cord-005453-4057qib7 13205 5 we -PRON- PRP cord-005453-4057qib7 13205 6 used use VBD cord-005453-4057qib7 13205 7 Defibrotid Defibrotid NNP cord-005453-4057qib7 13205 8 to to TO cord-005453-4057qib7 13205 9 protect protect VB cord-005453-4057qib7 13205 10 our -PRON- PRP$ cord-005453-4057qib7 13205 11 patient patient NN cord-005453-4057qib7 13205 12 from from IN cord-005453-4057qib7 13205 13 VOD VOD NNP cord-005453-4057qib7 13205 14 . . . cord-005453-4057qib7 13206 1 Conclusions conclusion NNS cord-005453-4057qib7 13206 2 : : : cord-005453-4057qib7 13207 1 Treatment treatment NN cord-005453-4057qib7 13207 2 with with IN cord-005453-4057qib7 13207 3 combination combination NN cord-005453-4057qib7 13207 4 CT CT NNP cord-005453-4057qib7 13207 5 regimens regimen NNS cord-005453-4057qib7 13207 6 in in IN cord-005453-4057qib7 13207 7 B b NN cord-005453-4057qib7 13207 8 - - : cord-005453-4057qib7 13207 9 ALL all DT cord-005453-4057qib7 13207 10 is be VBZ cord-005453-4057qib7 13207 11 suboptimal suboptimal JJ cord-005453-4057qib7 13207 12 and and CC cord-005453-4057qib7 13207 13 long long JJ cord-005453-4057qib7 13207 14 - - HYPH cord-005453-4057qib7 13207 15 term term NN cord-005453-4057qib7 13207 16 survival survival NN cord-005453-4057qib7 13207 17 is be VBZ cord-005453-4057qib7 13207 18 achieved achieve VBN cord-005453-4057qib7 13207 19 in in IN cord-005453-4057qib7 13207 20 only only RB cord-005453-4057qib7 13207 21 30 30 CD cord-005453-4057qib7 13207 22 - - SYM cord-005453-4057qib7 13207 23 40 40 CD cord-005453-4057qib7 13207 24 % % NN cord-005453-4057qib7 13207 25 of of IN cord-005453-4057qib7 13207 26 patients patient NNS cord-005453-4057qib7 13207 27 . . . cord-005453-4057qib7 13208 1 Targeted target VBN cord-005453-4057qib7 13208 2 molecular molecular JJ cord-005453-4057qib7 13208 3 therapy therapy NN cord-005453-4057qib7 13208 4 and and CC cord-005453-4057qib7 13208 5 new new JJ cord-005453-4057qib7 13208 6 regimens regimen NNS cord-005453-4057qib7 13208 7 are be VBP cord-005453-4057qib7 13208 8 needed need VBN cord-005453-4057qib7 13208 9 in in IN cord-005453-4057qib7 13208 10 relapse relapse NN cord-005453-4057qib7 13208 11 and and CC cord-005453-4057qib7 13208 12 resistant resistant JJ cord-005453-4057qib7 13208 13 patients patient NNS cord-005453-4057qib7 13208 14 . . . cord-005453-4057qib7 13209 1 At at IN cord-005453-4057qib7 13209 2 this this DT cord-005453-4057qib7 13209 3 point point NN cord-005453-4057qib7 13209 4 , , , cord-005453-4057qib7 13209 5 Inotuzumab Inotuzumab NNP cord-005453-4057qib7 13209 6 ozogamycin ozogamycin NN cord-005453-4057qib7 13209 7 is be VBZ cord-005453-4057qib7 13209 8 an an DT cord-005453-4057qib7 13209 9 anti anti JJ cord-005453-4057qib7 13209 10 - - JJ cord-005453-4057qib7 13209 11 CD-22 cd-22 JJ cord-005453-4057qib7 13209 12 monoclonal monoclonal JJ cord-005453-4057qib7 13209 13 antibody antibody NN cord-005453-4057qib7 13209 14 , , , cord-005453-4057qib7 13209 15 as as IN cord-005453-4057qib7 13209 16 in in IN cord-005453-4057qib7 13209 17 our -PRON- PRP$ cord-005453-4057qib7 13209 18 case case NN cord-005453-4057qib7 13209 19 , , , cord-005453-4057qib7 13209 20 it -PRON- PRP cord-005453-4057qib7 13209 21 provides provide VBZ cord-005453-4057qib7 13209 22 remission remission NN cord-005453-4057qib7 13209 23 in in IN cord-005453-4057qib7 13209 24 recurrent recurrent JJ cord-005453-4057qib7 13209 25 and and CC cord-005453-4057qib7 13209 26 resistant resistant JJ cord-005453-4057qib7 13209 27 B b NN cord-005453-4057qib7 13209 28 - - : cord-005453-4057qib7 13209 29 ALL all DT cord-005453-4057qib7 13209 30 patients patient NNS cord-005453-4057qib7 13209 31 and and CC cord-005453-4057qib7 13209 32 allows allow VBZ cord-005453-4057qib7 13209 33 patients patient NNS cord-005453-4057qib7 13209 34 to to TO cord-005453-4057qib7 13209 35 complete complete VB cord-005453-4057qib7 13209 36 their -PRON- PRP$ cord-005453-4057qib7 13209 37 treatment treatment NN cord-005453-4057qib7 13209 38 with with IN cord-005453-4057qib7 13209 39 an an DT cord-005453-4057qib7 13209 40 allogeneic allogeneic NN cord-005453-4057qib7 13209 41 transplant transplant NN cord-005453-4057qib7 13209 42 from from IN cord-005453-4057qib7 13209 43 a a DT cord-005453-4057qib7 13209 44 fully fully RB cord-005453-4057qib7 13209 45 compatible compatible JJ cord-005453-4057qib7 13209 46 donor donor NN cord-005453-4057qib7 13209 47 . . . cord-005453-4057qib7 13210 1 Disclosure disclosure NN cord-005453-4057qib7 13210 2 : : : cord-005453-4057qib7 13210 3 Nothing nothing NN cord-005453-4057qib7 13210 4 to to TO cord-005453-4057qib7 13210 5 declare declare VB cord-005453-4057qib7 13210 6 Background background NN cord-005453-4057qib7 13210 7 : : : cord-005453-4057qib7 13210 8 Mesenchymal Mesenchymal NNS cord-005453-4057qib7 13210 9 stem stem VBP cord-005453-4057qib7 13210 10 cells cell NNS cord-005453-4057qib7 13210 11 ( ( -LRB- cord-005453-4057qib7 13210 12 MSCs msc NNS cord-005453-4057qib7 13210 13 ) ) -RRB- cord-005453-4057qib7 13210 14 are be VBP cord-005453-4057qib7 13210 15 an an DT cord-005453-4057qib7 13210 16 attractive attractive JJ cord-005453-4057qib7 13210 17 consideration consideration NN cord-005453-4057qib7 13210 18 for for IN cord-005453-4057qib7 13210 19 therapeutic therapeutic JJ cord-005453-4057qib7 13210 20 cures cure NNS cord-005453-4057qib7 13210 21 of of IN cord-005453-4057qib7 13210 22 many many JJ cord-005453-4057qib7 13210 23 difficult difficult JJ cord-005453-4057qib7 13210 24 diseases disease NNS cord-005453-4057qib7 13210 25 on on IN cord-005453-4057qib7 13210 26 the the DT cord-005453-4057qib7 13210 27 cellular cellular JJ cord-005453-4057qib7 13210 28 - - HYPH cord-005453-4057qib7 13210 29 level level NN cord-005453-4057qib7 13210 30 . . . cord-005453-4057qib7 13211 1 Due due IN cord-005453-4057qib7 13211 2 to to IN cord-005453-4057qib7 13211 3 the the DT cord-005453-4057qib7 13211 4 trophic trophic JJ cord-005453-4057qib7 13211 5 effects effect NNS cord-005453-4057qib7 13211 6 of of IN cord-005453-4057qib7 13211 7 the the DT cord-005453-4057qib7 13211 8 cytokines cytokine NNS cord-005453-4057qib7 13211 9 and and CC cord-005453-4057qib7 13211 10 chemokines chemokine NNS cord-005453-4057qib7 13211 11 that that IN cord-005453-4057qib7 13211 12 they -PRON- PRP cord-005453-4057qib7 13211 13 produce produce VBP cord-005453-4057qib7 13211 14 , , , cord-005453-4057qib7 13211 15 MSCs msc NNS cord-005453-4057qib7 13211 16 have have VBP cord-005453-4057qib7 13211 17 shown show VBN cord-005453-4057qib7 13211 18 multiple multiple JJ cord-005453-4057qib7 13211 19 beneficial beneficial JJ cord-005453-4057qib7 13211 20 properties property NNS cord-005453-4057qib7 13211 21 in in IN cord-005453-4057qib7 13211 22 the the DT cord-005453-4057qib7 13211 23 field field NN cord-005453-4057qib7 13211 24 of of IN cord-005453-4057qib7 13211 25 oncology oncology NN cord-005453-4057qib7 13211 26 . . . cord-005453-4057qib7 13212 1 In in IN cord-005453-4057qib7 13212 2 this this DT cord-005453-4057qib7 13212 3 study study NN cord-005453-4057qib7 13212 4 , , , cord-005453-4057qib7 13212 5 we -PRON- PRP cord-005453-4057qib7 13212 6 will will MD cord-005453-4057qib7 13212 7 be be VB cord-005453-4057qib7 13212 8 investigating investigate VBG cord-005453-4057qib7 13212 9 the the DT cord-005453-4057qib7 13212 10 effect effect NN cord-005453-4057qib7 13212 11 of of IN cord-005453-4057qib7 13212 12 MSCs msc NNS cord-005453-4057qib7 13212 13 derived derive VBN cord-005453-4057qib7 13212 14 from from IN cord-005453-4057qib7 13212 15 human human JJ cord-005453-4057qib7 13212 16 bone bone NN cord-005453-4057qib7 13212 17 marrow marrow NN cord-005453-4057qib7 13212 18 ( ( -LRB- cord-005453-4057qib7 13212 19 BM BM NNP cord-005453-4057qib7 13212 20 ) ) -RRB- cord-005453-4057qib7 13212 21 , , , cord-005453-4057qib7 13212 22 adipose adipose JJ cord-005453-4057qib7 13212 23 tissue tissue NN cord-005453-4057qib7 13212 24 ( ( -LRB- cord-005453-4057qib7 13212 25 AT AT NNP cord-005453-4057qib7 13212 26 ) ) -RRB- cord-005453-4057qib7 13212 27 , , , cord-005453-4057qib7 13212 28 and and CC cord-005453-4057qib7 13212 29 umbilical umbilical JJ cord-005453-4057qib7 13212 30 cord cord NN cord-005453-4057qib7 13212 31 derived derive VBN cord-005453-4057qib7 13212 32 MSCs mscs NN cord-005453-4057qib7 13212 33 ( ( -LRB- cord-005453-4057qib7 13212 34 UC UC NNP cord-005453-4057qib7 13212 35 - - HYPH cord-005453-4057qib7 13212 36 MSCs MSCs NNP cord-005453-4057qib7 13212 37 ) ) -RRB- cord-005453-4057qib7 13212 38 on on IN cord-005453-4057qib7 13212 39 ovarian ovarian JJ cord-005453-4057qib7 13212 40 cancer cancer NN cord-005453-4057qib7 13212 41 . . . cord-005453-4057qib7 13213 1 To to TO cord-005453-4057qib7 13213 2 differentiate differentiate VB cord-005453-4057qib7 13213 3 the the DT cord-005453-4057qib7 13213 4 MSCs msc NNS cord-005453-4057qib7 13213 5 , , , cord-005453-4057qib7 13213 6 we -PRON- PRP cord-005453-4057qib7 13213 7 performed perform VBD cord-005453-4057qib7 13213 8 a a DT cord-005453-4057qib7 13213 9 comparative comparative JJ cord-005453-4057qib7 13213 10 analysis analysis NN cord-005453-4057qib7 13213 11 between between IN cord-005453-4057qib7 13213 12 the the DT cord-005453-4057qib7 13213 13 various various JJ cord-005453-4057qib7 13213 14 sources source NNS cord-005453-4057qib7 13213 15 for for IN cord-005453-4057qib7 13213 16 proliferative proliferative JJ cord-005453-4057qib7 13213 17 capacity capacity NN cord-005453-4057qib7 13213 18 , , , cord-005453-4057qib7 13213 19 surface surface NN cord-005453-4057qib7 13213 20 antigen antigen NN cord-005453-4057qib7 13213 21 expression expression NN cord-005453-4057qib7 13213 22 , , , cord-005453-4057qib7 13213 23 differentiation differentiation NN cord-005453-4057qib7 13213 24 ability ability NN cord-005453-4057qib7 13213 25 , , , cord-005453-4057qib7 13213 26 tumor tumor NN cord-005453-4057qib7 13213 27 marker marker NN cord-005453-4057qib7 13213 28 and and CC cord-005453-4057qib7 13213 29 paracrine paracrine JJ cord-005453-4057qib7 13213 30 activity activity NN cord-005453-4057qib7 13213 31 , , , cord-005453-4057qib7 13213 32 and and CC cord-005453-4057qib7 13213 33 their -PRON- PRP$ cord-005453-4057qib7 13213 34 influence influence NN cord-005453-4057qib7 13213 35 on on IN cord-005453-4057qib7 13213 36 ovarian ovarian JJ cord-005453-4057qib7 13213 37 cancer cancer NN cord-005453-4057qib7 13213 38 cell cell NN cord-005453-4057qib7 13213 39 proliferation proliferation NN cord-005453-4057qib7 13213 40 . . . cord-005453-4057qib7 13214 1 Methods method NNS cord-005453-4057qib7 13214 2 : : : cord-005453-4057qib7 13214 3 Measurements measurement NNS cord-005453-4057qib7 13214 4 of of IN cord-005453-4057qib7 13214 5 ovarian ovarian JJ cord-005453-4057qib7 13214 6 tumor tumor NN cord-005453-4057qib7 13214 7 marker marker NN cord-005453-4057qib7 13214 8 proteins protein NNS cord-005453-4057qib7 13214 9 were be VBD cord-005453-4057qib7 13214 10 computed compute VBN cord-005453-4057qib7 13214 11 by by IN cord-005453-4057qib7 13214 12 ELISA ELISA NNP cord-005453-4057qib7 13214 13 . . . cord-005453-4057qib7 13215 1 Proliferative proliferative JJ cord-005453-4057qib7 13215 2 effects effect NNS cord-005453-4057qib7 13215 3 , , , cord-005453-4057qib7 13215 4 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 13215 5 effects effect NNS cord-005453-4057qib7 13215 6 , , , cord-005453-4057qib7 13215 7 and and CC cord-005453-4057qib7 13215 8 apoptosis apoptosis NN cord-005453-4057qib7 13215 9 of of IN cord-005453-4057qib7 13215 10 the the DT cord-005453-4057qib7 13215 11 MSCs msc NNS cord-005453-4057qib7 13215 12 were be VBD cord-005453-4057qib7 13215 13 measured measure VBN cord-005453-4057qib7 13215 14 by by IN cord-005453-4057qib7 13215 15 the the DT cord-005453-4057qib7 13215 16 culture culture NN cord-005453-4057qib7 13215 17 and and CC cord-005453-4057qib7 13215 18 counting counting NN cord-005453-4057qib7 13215 19 of of IN cord-005453-4057qib7 13215 20 colony colony NN cord-005453-4057qib7 13215 21 formations formation NNS cord-005453-4057qib7 13215 22 . . . cord-005453-4057qib7 13216 1 Flow flow NN cord-005453-4057qib7 13216 2 cytometry cytometry NN cord-005453-4057qib7 13216 3 ( ( -LRB- cord-005453-4057qib7 13216 4 FCM FCM NNP cord-005453-4057qib7 13216 5 ) ) -RRB- cord-005453-4057qib7 13216 6 was be VBD cord-005453-4057qib7 13216 7 used use VBN cord-005453-4057qib7 13216 8 to to TO cord-005453-4057qib7 13216 9 measure measure VB cord-005453-4057qib7 13216 10 the the DT cord-005453-4057qib7 13216 11 variation variation NN cord-005453-4057qib7 13216 12 of of IN cord-005453-4057qib7 13216 13 the the DT cord-005453-4057qib7 13216 14 immunophenotyping immunophenotyping NN cord-005453-4057qib7 13216 15 and and CC cord-005453-4057qib7 13216 16 cytokine cytokine NN cord-005453-4057qib7 13216 17 secretions secretion NNS cord-005453-4057qib7 13216 18 in in IN cord-005453-4057qib7 13216 19 co co NN cord-005453-4057qib7 13216 20 - - NN cord-005453-4057qib7 13216 21 culture culture NN cord-005453-4057qib7 13216 22 , , , cord-005453-4057qib7 13216 23 as as RB cord-005453-4057qib7 13216 24 well well RB cord-005453-4057qib7 13216 25 as as IN cord-005453-4057qib7 13216 26 gene gene NN cord-005453-4057qib7 13216 27 expression expression NN cord-005453-4057qib7 13216 28 . . . cord-005453-4057qib7 13217 1 Results result NNS cord-005453-4057qib7 13217 2 : : : cord-005453-4057qib7 13218 1 Cells cell NNS cord-005453-4057qib7 13218 2 noticeably noticeably RB cord-005453-4057qib7 13218 3 proliferated proliferate VBD cord-005453-4057qib7 13218 4 without without IN cord-005453-4057qib7 13218 5 any any DT cord-005453-4057qib7 13218 6 modifications modification NNS cord-005453-4057qib7 13218 7 to to IN cord-005453-4057qib7 13218 8 their -PRON- PRP$ cord-005453-4057qib7 13218 9 immunophenotype immunophenotype NN cord-005453-4057qib7 13218 10 during during IN cord-005453-4057qib7 13218 11 the the DT cord-005453-4057qib7 13218 12 third third JJ cord-005453-4057qib7 13218 13 subculture subculture NN cord-005453-4057qib7 13218 14 . . . cord-005453-4057qib7 13219 1 The the DT cord-005453-4057qib7 13219 2 colony colony NN cord-005453-4057qib7 13219 3 - - HYPH cord-005453-4057qib7 13219 4 forming form VBG cord-005453-4057qib7 13219 5 unit unit NN cord-005453-4057qib7 13219 6 fibroblast fibroblast NN cord-005453-4057qib7 13219 7 ( ( -LRB- cord-005453-4057qib7 13219 8 CFU CFU NNP cord-005453-4057qib7 13219 9 - - HYPH cord-005453-4057qib7 13219 10 F F NNP cord-005453-4057qib7 13219 11 ) ) -RRB- cord-005453-4057qib7 13219 12 test test NN cord-005453-4057qib7 13219 13 showed show VBD cord-005453-4057qib7 13219 14 a a DT cord-005453-4057qib7 13219 15 proliferation proliferation NN cord-005453-4057qib7 13219 16 of of IN cord-005453-4057qib7 13219 17 the the DT cord-005453-4057qib7 13219 18 MSCs msc NNS cord-005453-4057qib7 13219 19 along along IN cord-005453-4057qib7 13219 20 with with IN cord-005453-4057qib7 13219 21 healthy healthy JJ cord-005453-4057qib7 13219 22 cells cell NNS cord-005453-4057qib7 13219 23 and and CC cord-005453-4057qib7 13219 24 cancer cancer NN cord-005453-4057qib7 13219 25 cell cell NN cord-005453-4057qib7 13219 26 lines line NNS cord-005453-4057qib7 13219 27 with with IN cord-005453-4057qib7 13219 28 no no DT cord-005453-4057qib7 13219 29 changes change NNS cord-005453-4057qib7 13219 30 in in IN cord-005453-4057qib7 13219 31 their -PRON- PRP$ cord-005453-4057qib7 13219 32 phenotype phenotype NN cord-005453-4057qib7 13219 33 . . . cord-005453-4057qib7 13220 1 The the DT cord-005453-4057qib7 13220 2 supernatant supernatant NN cord-005453-4057qib7 13220 3 of of IN cord-005453-4057qib7 13220 4 MSCs msc NNS cord-005453-4057qib7 13220 5 showed show VBD cord-005453-4057qib7 13220 6 an an DT cord-005453-4057qib7 13220 7 increase increase NN cord-005453-4057qib7 13220 8 in in IN cord-005453-4057qib7 13220 9 cellular cellular JJ cord-005453-4057qib7 13220 10 death death NN cord-005453-4057qib7 13220 11 of of IN cord-005453-4057qib7 13220 12 the the DT cord-005453-4057qib7 13220 13 OVCAR3 ovcar3 NN cord-005453-4057qib7 13220 14 in in IN cord-005453-4057qib7 13220 15 ovarian ovarian JJ cord-005453-4057qib7 13220 16 cancer cancer NN cord-005453-4057qib7 13220 17 cell cell NN cord-005453-4057qib7 13220 18 lines line NNS cord-005453-4057qib7 13220 19 . . . cord-005453-4057qib7 13221 1 A a DT cord-005453-4057qib7 13221 2 reduction reduction NN cord-005453-4057qib7 13221 3 in in IN cord-005453-4057qib7 13221 4 the the DT cord-005453-4057qib7 13221 5 level level NN cord-005453-4057qib7 13221 6 of of IN cord-005453-4057qib7 13221 7 CA-125 ca-125 NN cord-005453-4057qib7 13221 8 ( ( -LRB- cord-005453-4057qib7 13221 9 75 75 CD cord-005453-4057qib7 13221 10 - - SYM cord-005453-4057qib7 13221 11 90 90 CD cord-005453-4057qib7 13221 12 % % NN cord-005453-4057qib7 13221 13 ; ; : cord-005453-4057qib7 13221 14 p=0.769 p=0.769 ADD cord-005453-4057qib7 13221 15 ) ) -RRB- cord-005453-4057qib7 13221 16 with with IN cord-005453-4057qib7 13221 17 OVCAR3 OVCAR3 NNP cord-005453-4057qib7 13221 18 in in IN cord-005453-4057qib7 13221 19 co co NN cord-005453-4057qib7 13221 20 - - NN cord-005453-4057qib7 13221 21 culture culture NN cord-005453-4057qib7 13221 22 , , , cord-005453-4057qib7 13221 23 and and CC cord-005453-4057qib7 13221 24 a a DT cord-005453-4057qib7 13221 25 decline decline NN cord-005453-4057qib7 13221 26 of of IN cord-005453-4057qib7 13221 27 LDH LDH NNP cord-005453-4057qib7 13221 28 ( ( -LRB- cord-005453-4057qib7 13221 29 10 10 CD cord-005453-4057qib7 13221 30 - - SYM cord-005453-4057qib7 13221 31 20 20 CD cord-005453-4057qib7 13221 32 % % NN cord-005453-4057qib7 13221 33 ; ; : cord-005453-4057qib7 13221 34 p=0.03 p=0.03 NN cord-005453-4057qib7 13221 35 ) ) -RRB- cord-005453-4057qib7 13221 36 and and CC cord-005453-4057qib7 13221 37 beta beta NN cord-005453-4057qib7 13221 38 - - HYPH cord-005453-4057qib7 13221 39 hCG hcg NN cord-005453-4057qib7 13221 40 ( ( -LRB- cord-005453-4057qib7 13221 41 10 10 CD cord-005453-4057qib7 13221 42 - - SYM cord-005453-4057qib7 13221 43 20 20 CD cord-005453-4057qib7 13221 44 % % NN cord-005453-4057qib7 13221 45 ; ; : cord-005453-4057qib7 13221 46 p=0.04 p=0.04 NN cord-005453-4057qib7 13221 47 ) ) -RRB- cord-005453-4057qib7 13221 48 were be VBD cord-005453-4057qib7 13221 49 observed observe VBN cord-005453-4057qib7 13221 50 in in IN cord-005453-4057qib7 13221 51 co co NN cord-005453-4057qib7 13221 52 - - NN cord-005453-4057qib7 13221 53 culture culture NN cord-005453-4057qib7 13221 54 in in IN cord-005453-4057qib7 13221 55 CAOV3 CAOV3 NNP cord-005453-4057qib7 13221 56 , , , cord-005453-4057qib7 13221 57 SKOV3 SKOV3 NNP cord-005453-4057qib7 13221 58 and and CC cord-005453-4057qib7 13221 59 IGROV3 igrov3 JJ cord-005453-4057qib7 13221 60 cell cell NN cord-005453-4057qib7 13221 61 lines line NNS cord-005453-4057qib7 13221 62 . . . cord-005453-4057qib7 13222 1 A a DT cord-005453-4057qib7 13222 2 decrease decrease NN cord-005453-4057qib7 13222 3 in in IN cord-005453-4057qib7 13222 4 CD24 CD24 NNP cord-005453-4057qib7 13222 5 of of IN cord-005453-4057qib7 13222 6 the the DT cord-005453-4057qib7 13222 7 cancer cancer NN cord-005453-4057qib7 13222 8 cell cell NN cord-005453-4057qib7 13222 9 lines line NNS cord-005453-4057qib7 13222 10 in in IN cord-005453-4057qib7 13222 11 co co NN cord-005453-4057qib7 13222 12 - - NN cord-005453-4057qib7 13222 13 culture culture NN cord-005453-4057qib7 13222 14 with with IN cord-005453-4057qib7 13222 15 the the DT cord-005453-4057qib7 13222 16 MSC MSC NNP cord-005453-4057qib7 13222 17 supernatant supernatant NN cord-005453-4057qib7 13222 18 showed show VBD cord-005453-4057qib7 13222 19 a a DT cord-005453-4057qib7 13222 20 reduction reduction NN cord-005453-4057qib7 13222 21 of of IN cord-005453-4057qib7 13222 22 the the DT cord-005453-4057qib7 13222 23 cancer cancer NN cord-005453-4057qib7 13222 24 tumorigenicity tumorigenicity NN cord-005453-4057qib7 13222 25 and and CC cord-005453-4057qib7 13222 26 aggressiveness aggressiveness NN cord-005453-4057qib7 13222 27 , , , cord-005453-4057qib7 13222 28 while while IN cord-005453-4057qib7 13222 29 the the DT cord-005453-4057qib7 13222 30 rate rate NN cord-005453-4057qib7 13222 31 of of IN cord-005453-4057qib7 13222 32 the the DT cord-005453-4057qib7 13222 33 CD24 CD24 NNP cord-005453-4057qib7 13222 34 and and CC cord-005453-4057qib7 13222 35 CD44 CD44 NNP cord-005453-4057qib7 13222 36 asserted assert VBD cord-005453-4057qib7 13222 37 their -PRON- PRP$ cord-005453-4057qib7 13222 38 stem stem NN cord-005453-4057qib7 13222 39 state state NN cord-005453-4057qib7 13222 40 . . . cord-005453-4057qib7 13223 1 MSC MSC NNP cord-005453-4057qib7 13223 2 supernatant supernatant JJ cord-005453-4057qib7 13223 3 decreased decrease VBD cord-005453-4057qib7 13223 4 cell cell NN cord-005453-4057qib7 13223 5 proliferation proliferation NN cord-005453-4057qib7 13223 6 and and CC cord-005453-4057qib7 13223 7 MMP-2 MMP-2 NNP cord-005453-4057qib7 13223 8 , , , cord-005453-4057qib7 13223 9 MMP-9 MMP-9 NNP cord-005453-4057qib7 13223 10 , , , cord-005453-4057qib7 13223 11 and and CC cord-005453-4057qib7 13223 12 CA-125 CA-125 NNP cord-005453-4057qib7 13223 13 mRNA mRNA NNP cord-005453-4057qib7 13223 14 expression expression NN cord-005453-4057qib7 13223 15 , , , cord-005453-4057qib7 13223 16 while while IN cord-005453-4057qib7 13223 17 increasing increase VBG cord-005453-4057qib7 13223 18 TIMP TIMP NNP cord-005453-4057qib7 13223 19 1 1 CD cord-005453-4057qib7 13223 20 , , , cord-005453-4057qib7 13223 21 2 2 CD cord-005453-4057qib7 13223 22 , , , cord-005453-4057qib7 13223 23 and and CC cord-005453-4057qib7 13223 24 3 3 CD cord-005453-4057qib7 13223 25 . . . cord-005453-4057qib7 13224 1 This this DT cord-005453-4057qib7 13224 2 suggests suggest VBZ cord-005453-4057qib7 13224 3 that that IN cord-005453-4057qib7 13224 4 MSCs msc NNS cord-005453-4057qib7 13224 5 have have VBP cord-005453-4057qib7 13224 6 a a DT cord-005453-4057qib7 13224 7 role role NN cord-005453-4057qib7 13224 8 in in IN cord-005453-4057qib7 13224 9 cell cell NN cord-005453-4057qib7 13224 10 death death NN cord-005453-4057qib7 13224 11 and and CC cord-005453-4057qib7 13224 12 inhibition inhibition NN cord-005453-4057qib7 13224 13 of of IN cord-005453-4057qib7 13224 14 ovarian ovarian JJ cord-005453-4057qib7 13224 15 cancer cancer NN cord-005453-4057qib7 13224 16 cell cell NN cord-005453-4057qib7 13224 17 proliferation proliferation NN cord-005453-4057qib7 13224 18 . . . cord-005453-4057qib7 13225 1 An an DT cord-005453-4057qib7 13225 2 increase increase NN cord-005453-4057qib7 13225 3 of of IN cord-005453-4057qib7 13225 4 anti anti JJ cord-005453-4057qib7 13225 5 - - JJ cord-005453-4057qib7 13225 6 inflammatory inflammatory JJ cord-005453-4057qib7 13225 7 IL-4 IL-4 NNP cord-005453-4057qib7 13225 8 and and CC cord-005453-4057qib7 13225 9 IL-10 IL-10 NNP cord-005453-4057qib7 13225 10 cytokines cytokine NNS cord-005453-4057qib7 13225 11 , , , cord-005453-4057qib7 13225 12 and and CC cord-005453-4057qib7 13225 13 a a DT cord-005453-4057qib7 13225 14 decrease decrease NN cord-005453-4057qib7 13225 15 in in IN cord-005453-4057qib7 13225 16 growth growth NN cord-005453-4057qib7 13225 17 factor factor NN cord-005453-4057qib7 13225 18 GM GM NNP cord-005453-4057qib7 13225 19 - - HYPH cord-005453-4057qib7 13225 20 CSF CSF NNP cord-005453-4057qib7 13225 21 along along IN cord-005453-4057qib7 13225 22 with with IN cord-005453-4057qib7 13225 23 their -PRON- PRP$ cord-005453-4057qib7 13225 24 proinflammatory proinflammatory JJ cord-005453-4057qib7 13225 25 INF inf NN cord-005453-4057qib7 13225 26 - - , cord-005453-4057qib7 13225 27 a a NN cord-005453-4057qib7 13225 28 , , , cord-005453-4057qib7 13225 29 TNF TNF NNP cord-005453-4057qib7 13225 30 - - HYPH cord-005453-4057qib7 13225 31 a a NNP cord-005453-4057qib7 13225 32 , , , cord-005453-4057qib7 13225 33 IL-9 IL-9 NNP cord-005453-4057qib7 13225 34 , , , cord-005453-4057qib7 13225 35 and and CC cord-005453-4057qib7 13225 36 IL-17a IL-17a NNP cord-005453-4057qib7 13225 37 cytokines cytokine NNS cord-005453-4057qib7 13225 38 were be VBD cord-005453-4057qib7 13225 39 also also RB cord-005453-4057qib7 13225 40 noted note VBN cord-005453-4057qib7 13225 41 . . . cord-005453-4057qib7 13226 1 Conclusions conclusion NNS cord-005453-4057qib7 13226 2 : : : cord-005453-4057qib7 13227 1 The the DT cord-005453-4057qib7 13227 2 gene gene NN cord-005453-4057qib7 13227 3 and and CC cord-005453-4057qib7 13227 4 cytokine cytokine NN cord-005453-4057qib7 13227 5 activity activity NN cord-005453-4057qib7 13227 6 indicate indicate VBP cord-005453-4057qib7 13227 7 a a DT cord-005453-4057qib7 13227 8 potential potential JJ cord-005453-4057qib7 13227 9 therapeutic therapeutic JJ cord-005453-4057qib7 13227 10 anti anti JJ cord-005453-4057qib7 13227 11 - - JJ cord-005453-4057qib7 13227 12 inflammatory inflammatory JJ cord-005453-4057qib7 13227 13 and and CC cord-005453-4057qib7 13227 14 antiproliferative antiproliferative JJ cord-005453-4057qib7 13227 15 role role NN cord-005453-4057qib7 13227 16 of of IN cord-005453-4057qib7 13227 17 MSCs msc NNS cord-005453-4057qib7 13227 18 on on IN cord-005453-4057qib7 13227 19 ovarian ovarian JJ cord-005453-4057qib7 13227 20 cancer cancer NN cord-005453-4057qib7 13227 21 despite despite IN cord-005453-4057qib7 13227 22 their -PRON- PRP$ cord-005453-4057qib7 13227 23 sources source NNS cord-005453-4057qib7 13227 24 . . . cord-005453-4057qib7 13228 1 The the DT cord-005453-4057qib7 13228 2 reduction reduction NN cord-005453-4057qib7 13228 3 of of IN cord-005453-4057qib7 13228 4 CA-125 ca-125 NN cord-005453-4057qib7 13228 5 , , , cord-005453-4057qib7 13228 6 LDH LDH NNP cord-005453-4057qib7 13228 7 , , , cord-005453-4057qib7 13228 8 and and CC cord-005453-4057qib7 13228 9 beta beta NN cord-005453-4057qib7 13228 10 - - HYPH cord-005453-4057qib7 13228 11 hCG hcg NN cord-005453-4057qib7 13228 12 in in IN cord-005453-4057qib7 13228 13 co co NN cord-005453-4057qib7 13228 14 - - NN cord-005453-4057qib7 13228 15 culture culture NN cord-005453-4057qib7 13228 16 , , , cord-005453-4057qib7 13228 17 along along IN cord-005453-4057qib7 13228 18 with with IN cord-005453-4057qib7 13228 19 the the DT cord-005453-4057qib7 13228 20 decrease decrease NN cord-005453-4057qib7 13228 21 in in IN cord-005453-4057qib7 13228 22 CD24 CD24 NNP cord-005453-4057qib7 13228 23 and and CC cord-005453-4057qib7 13228 24 amplified amplify VBD cord-005453-4057qib7 13228 25 cellular cellular JJ cord-005453-4057qib7 13228 26 apoptosis apoptosis NN cord-005453-4057qib7 13228 27 demonstrate demonstrate VBP cord-005453-4057qib7 13228 28 the the DT cord-005453-4057qib7 13228 29 beneficial beneficial JJ cord-005453-4057qib7 13228 30 effects effect NNS cord-005453-4057qib7 13228 31 of of IN cord-005453-4057qib7 13228 32 stem stem NN cord-005453-4057qib7 13228 33 cells cell NNS cord-005453-4057qib7 13228 34 in in IN cord-005453-4057qib7 13228 35 ovarian ovarian JJ cord-005453-4057qib7 13228 36 cancer cancer NN cord-005453-4057qib7 13228 37 cell cell NN cord-005453-4057qib7 13228 38 lines line NNS cord-005453-4057qib7 13228 39 . . . cord-005453-4057qib7 13229 1 Disclosure disclosure NN cord-005453-4057qib7 13229 2 Background background NN cord-005453-4057qib7 13229 3 : : : cord-005453-4057qib7 13229 4 Hematopoietic hematopoietic JJ cord-005453-4057qib7 13229 5 stem stem NN cord-005453-4057qib7 13229 6 cell cell NN cord-005453-4057qib7 13229 7 transplant transplant NN cord-005453-4057qib7 13229 8 ( ( -LRB- cord-005453-4057qib7 13229 9 HSCT HSCT NNP cord-005453-4057qib7 13229 10 ) ) -RRB- cord-005453-4057qib7 13229 11 is be VBZ cord-005453-4057qib7 13229 12 the the DT cord-005453-4057qib7 13229 13 only only JJ cord-005453-4057qib7 13229 14 cure cure NN cord-005453-4057qib7 13229 15 in in IN cord-005453-4057qib7 13229 16 sickle sickle NN cord-005453-4057qib7 13229 17 cell cell NN cord-005453-4057qib7 13229 18 disease disease NN cord-005453-4057qib7 13229 19 ( ( -LRB- cord-005453-4057qib7 13229 20 SCD SCD NNP cord-005453-4057qib7 13229 21 ) ) -RRB- cord-005453-4057qib7 13229 22 so so RB cord-005453-4057qib7 13229 23 far far RB cord-005453-4057qib7 13229 24 . . . cord-005453-4057qib7 13230 1 Because because IN cord-005453-4057qib7 13230 2 of of IN cord-005453-4057qib7 13230 3 the the DT cord-005453-4057qib7 13230 4 risk risk NN cord-005453-4057qib7 13230 5 of of IN cord-005453-4057qib7 13230 6 toxicity toxicity NN cord-005453-4057qib7 13230 7 , , , cord-005453-4057qib7 13230 8 its -PRON- PRP$ cord-005453-4057qib7 13230 9 indication indication NN cord-005453-4057qib7 13230 10 in in IN cord-005453-4057qib7 13230 11 France France NNP cord-005453-4057qib7 13230 12 is be VBZ cord-005453-4057qib7 13230 13 restricted restrict VBN cord-005453-4057qib7 13230 14 to to IN cord-005453-4057qib7 13230 15 severe severe JJ cord-005453-4057qib7 13230 16 patients patient NNS cord-005453-4057qib7 13230 17 with with IN cord-005453-4057qib7 13230 18 match match NN cord-005453-4057qib7 13230 19 sibling sibling NN cord-005453-4057qib7 13230 20 donor donor NN cord-005453-4057qib7 13230 21 . . . cord-005453-4057qib7 13231 1 This this DT cord-005453-4057qib7 13231 2 study study NN cord-005453-4057qib7 13231 3 compares compare VBZ cord-005453-4057qib7 13231 4 the the DT cord-005453-4057qib7 13231 5 incidence incidence NN cord-005453-4057qib7 13231 6 of of IN cord-005453-4057qib7 13231 7 severe severe JJ cord-005453-4057qib7 13231 8 acute acute JJ cord-005453-4057qib7 13231 9 toxicity toxicity NN cord-005453-4057qib7 13231 10 after after IN cord-005453-4057qib7 13231 11 HSCT HSCT NNP cord-005453-4057qib7 13231 12 , , , cord-005453-4057qib7 13231 13 between between IN cord-005453-4057qib7 13231 14 children child NNS cord-005453-4057qib7 13231 15 aged age VBN cord-005453-4057qib7 13231 16 less less JJR cord-005453-4057qib7 13231 17 than than IN cord-005453-4057qib7 13231 18 13 13 CD cord-005453-4057qib7 13231 19 years year NNS cord-005453-4057qib7 13231 20 and and CC cord-005453-4057qib7 13231 21 teenagers teenager NNS cord-005453-4057qib7 13231 22 aged age VBN cord-005453-4057qib7 13231 23 13 13 CD cord-005453-4057qib7 13231 24 to to TO cord-005453-4057qib7 13231 25 18 18 CD cord-005453-4057qib7 13231 26 years year NNS cord-005453-4057qib7 13231 27 old old JJ cord-005453-4057qib7 13231 28 , , , cord-005453-4057qib7 13231 29 treated treat VBN cord-005453-4057qib7 13231 30 for for IN cord-005453-4057qib7 13231 31 SCD SCD NNP cord-005453-4057qib7 13231 32 . . . cord-005453-4057qib7 13232 1 Methods method NNS cord-005453-4057qib7 13232 2 : : : cord-005453-4057qib7 13233 1 All all DT cord-005453-4057qib7 13233 2 patients patient NNS cord-005453-4057qib7 13233 3 suffering suffer VBG cord-005453-4057qib7 13233 4 from from IN cord-005453-4057qib7 13233 5 SCD SCD NNP cord-005453-4057qib7 13233 6 , , , cord-005453-4057qib7 13233 7 aged aged JJ cord-005453-4057qib7 13233 8 less less JJR cord-005453-4057qib7 13233 9 than than IN cord-005453-4057qib7 13233 10 18 18 CD cord-005453-4057qib7 13233 11 years year NNS cord-005453-4057qib7 13233 12 at at IN cord-005453-4057qib7 13233 13 transplant transplant NN cord-005453-4057qib7 13233 14 , , , cord-005453-4057qib7 13233 15 who who WP cord-005453-4057qib7 13233 16 received receive VBD cord-005453-4057qib7 13233 17 HSCT HSCT NNP cord-005453-4057qib7 13233 18 in in IN cord-005453-4057qib7 13233 19 CHU CHU NNP cord-005453-4057qib7 13233 20 Robert Robert NNP cord-005453-4057qib7 13233 21 Debré Debré NNP cord-005453-4057qib7 13233 22 and and CC cord-005453-4057qib7 13233 23 Necker Necker NNP cord-005453-4057qib7 13233 24 , , , cord-005453-4057qib7 13233 25 between between IN cord-005453-4057qib7 13233 26 01/01/2005 01/01/2005 CD cord-005453-4057qib7 13233 27 and and CC cord-005453-4057qib7 13233 28 12/31/2017 12/31/2017 CD cord-005453-4057qib7 13233 29 , , , cord-005453-4057qib7 13233 30 were be VBD cord-005453-4057qib7 13233 31 included include VBN cord-005453-4057qib7 13233 32 . . . cord-005453-4057qib7 13234 1 Severe severe JJ cord-005453-4057qib7 13234 2 acute acute JJ cord-005453-4057qib7 13234 3 toxicity toxicity NN cord-005453-4057qib7 13234 4 , , , cord-005453-4057qib7 13234 5 defined define VBN cord-005453-4057qib7 13234 6 by by IN cord-005453-4057qib7 13234 7 onset onset NN cord-005453-4057qib7 13234 8 of of IN cord-005453-4057qib7 13234 9 severe severe JJ cord-005453-4057qib7 13234 10 acute acute JJ cord-005453-4057qib7 13234 11 GVHd GVHd NNS cord-005453-4057qib7 13234 12 , , , cord-005453-4057qib7 13234 13 organ organ NN cord-005453-4057qib7 13234 14 toxicity toxicity NN cord-005453-4057qib7 13234 15 or or CC cord-005453-4057qib7 13234 16 infection infection NN cord-005453-4057qib7 13234 17 , , , cord-005453-4057qib7 13234 18 was be VBD cord-005453-4057qib7 13234 19 compared compare VBN cord-005453-4057qib7 13234 20 between between IN cord-005453-4057qib7 13234 21 the the DT cord-005453-4057qib7 13234 22 two two CD cord-005453-4057qib7 13234 23 groups group NNS cord-005453-4057qib7 13234 24 of of IN cord-005453-4057qib7 13234 25 age age NN cord-005453-4057qib7 13234 26 . . . cord-005453-4057qib7 13235 1 Results result NNS cord-005453-4057qib7 13235 2 : : : cord-005453-4057qib7 13235 3 73 73 CD cord-005453-4057qib7 13235 4 patients patient NNS cord-005453-4057qib7 13235 5 ( ( -LRB- cord-005453-4057qib7 13235 6 59 59 CD cord-005453-4057qib7 13235 7 children child NNS cord-005453-4057qib7 13235 8 and and CC cord-005453-4057qib7 13235 9 14 14 CD cord-005453-4057qib7 13235 10 teenagers teenager NNS cord-005453-4057qib7 13235 11 ) ) -RRB- cord-005453-4057qib7 13235 12 were be VBD cord-005453-4057qib7 13235 13 included include VBN cord-005453-4057qib7 13235 14 . . . cord-005453-4057qib7 13236 1 All all DT cord-005453-4057qib7 13236 2 patients patient NNS cord-005453-4057qib7 13236 3 received receive VBD cord-005453-4057qib7 13236 4 a a DT cord-005453-4057qib7 13236 5 myeloablative myeloablative JJ cord-005453-4057qib7 13236 6 conditioning conditioning NN cord-005453-4057qib7 13236 7 regimen regimen NN cord-005453-4057qib7 13236 8 . . . cord-005453-4057qib7 13237 1 Bone bone NN cord-005453-4057qib7 13237 2 marrow marrow NN cord-005453-4057qib7 13237 3 from from IN cord-005453-4057qib7 13237 4 a a DT cord-005453-4057qib7 13237 5 sibling sibling NN cord-005453-4057qib7 13237 6 donor donor NN cord-005453-4057qib7 13237 7 was be VBD cord-005453-4057qib7 13237 8 the the DT cord-005453-4057qib7 13237 9 main main JJ cord-005453-4057qib7 13237 10 stem stem NN cord-005453-4057qib7 13237 11 cell cell NN cord-005453-4057qib7 13237 12 source source NN cord-005453-4057qib7 13237 13 ( ( -LRB- cord-005453-4057qib7 13237 14 n=65 n=65 NN cord-005453-4057qib7 13237 15 ; ; : cord-005453-4057qib7 13237 16 89 89 CD cord-005453-4057qib7 13237 17 % % NN cord-005453-4057qib7 13237 18 ) ) -RRB- cord-005453-4057qib7 13237 19 . . . cord-005453-4057qib7 13238 1 Neither neither DT cord-005453-4057qib7 13238 2 death death NN cord-005453-4057qib7 13238 3 nor nor CC cord-005453-4057qib7 13238 4 rejection rejection NN cord-005453-4057qib7 13238 5 was be VBD cord-005453-4057qib7 13238 6 observed observe VBN cord-005453-4057qib7 13238 7 with with IN cord-005453-4057qib7 13238 8 a a DT cord-005453-4057qib7 13238 9 median median JJ cord-005453-4057qib7 13238 10 follow follow NN cord-005453-4057qib7 13238 11 - - HYPH cord-005453-4057qib7 13238 12 up up NN cord-005453-4057qib7 13238 13 of of IN cord-005453-4057qib7 13238 14 29.6 29.6 CD cord-005453-4057qib7 13238 15 months month NNS cord-005453-4057qib7 13238 16 ( ( -LRB- cord-005453-4057qib7 13238 17 range range NN cord-005453-4057qib7 13238 18 , , , cord-005453-4057qib7 13238 19 . . . cord-005453-4057qib7 13239 1 The the DT cord-005453-4057qib7 13239 2 incidence incidence NN cord-005453-4057qib7 13239 3 of of IN cord-005453-4057qib7 13239 4 grade grade NN cord-005453-4057qib7 13239 5 III III NNP cord-005453-4057qib7 13239 6 - - HYPH cord-005453-4057qib7 13239 7 IV IV NNP cord-005453-4057qib7 13239 8 acute acute JJ cord-005453-4057qib7 13239 9 GVHd GVHd NNS cord-005453-4057qib7 13239 10 was be VBD cord-005453-4057qib7 13239 11 12.3 12.3 CD cord-005453-4057qib7 13239 12 % % NN cord-005453-4057qib7 13239 13 and and CC cord-005453-4057qib7 13239 14 was be VBD cord-005453-4057qib7 13239 15 similar similar JJ cord-005453-4057qib7 13239 16 between between IN cord-005453-4057qib7 13239 17 the the DT cord-005453-4057qib7 13239 18 two two CD cord-005453-4057qib7 13239 19 groups group NNS cord-005453-4057qib7 13239 20 ; ; : cord-005453-4057qib7 13239 21 no no DT cord-005453-4057qib7 13239 22 risk risk NN cord-005453-4057qib7 13239 23 factor factor NN cord-005453-4057qib7 13239 24 was be VBD cord-005453-4057qib7 13239 25 identified identify VBN cord-005453-4057qib7 13239 26 in in IN cord-005453-4057qib7 13239 27 univariate univariate JJ cord-005453-4057qib7 13239 28 analysis analysis NN cord-005453-4057qib7 13239 29 . . . cord-005453-4057qib7 13240 1 Teenagers teenager NNS cord-005453-4057qib7 13240 2 had have VBD cord-005453-4057qib7 13240 3 more more RBR cord-005453-4057qib7 13240 4 frequently frequently RB cord-005453-4057qib7 13240 5 acute acute JJ cord-005453-4057qib7 13240 6 skin skin NN cord-005453-4057qib7 13240 7 toxicity toxicity NN cord-005453-4057qib7 13240 8 ( ( -LRB- cord-005453-4057qib7 13240 9 21.4 21.4 CD cord-005453-4057qib7 13240 10 % % NN cord-005453-4057qib7 13240 11 vs vs IN cord-005453-4057qib7 13240 12 0 0 CD cord-005453-4057qib7 13240 13 % % NN cord-005453-4057qib7 13240 14 , , , cord-005453-4057qib7 13240 15 p=0.006 p=0.006 NNP cord-005453-4057qib7 13240 16 ) ) -RRB- cord-005453-4057qib7 13240 17 . . . cord-005453-4057qib7 13241 1 In in IN cord-005453-4057qib7 13241 2 univariate univariate JJ cord-005453-4057qib7 13241 3 analysis analysis NN cord-005453-4057qib7 13241 4 , , , cord-005453-4057qib7 13241 5 patients patient NNS cord-005453-4057qib7 13241 6 presenting present VBG cord-005453-4057qib7 13241 7 severe severe JJ cord-005453-4057qib7 13241 8 organ organ NN cord-005453-4057qib7 13241 9 toxicity toxicity NN cord-005453-4057qib7 13241 10 were be VBD cord-005453-4057qib7 13241 11 significantly significantly RB cord-005453-4057qib7 13241 12 older old JJR cord-005453-4057qib7 13241 13 than than IN cord-005453-4057qib7 13241 14 others other NNS cord-005453-4057qib7 13241 15 ( ( -LRB- cord-005453-4057qib7 13241 16 9.3 9.3 CD cord-005453-4057qib7 13241 17 vs vs IN cord-005453-4057qib7 13241 18 7.5 7.5 CD cord-005453-4057qib7 13241 19 years year NNS cord-005453-4057qib7 13241 20 old old JJ cord-005453-4057qib7 13241 21 , , , cord-005453-4057qib7 13241 22 p=0.027 p=0.027 RB cord-005453-4057qib7 13241 23 ) ) -RRB- cord-005453-4057qib7 13241 24 . . . cord-005453-4057qib7 13242 1 Teenagers teenager NNS cord-005453-4057qib7 13242 2 were be VBD cord-005453-4057qib7 13242 3 more more RBR cord-005453-4057qib7 13242 4 frequently frequently RB cord-005453-4057qib7 13242 5 treated treat VBN cord-005453-4057qib7 13242 6 for for IN cord-005453-4057qib7 13242 7 bacterial bacterial JJ cord-005453-4057qib7 13242 8 ( ( -LRB- cord-005453-4057qib7 13242 9 64.3 64.3 CD cord-005453-4057qib7 13242 10 % % NN cord-005453-4057qib7 13242 11 vs vs IN cord-005453-4057qib7 13242 12 32.2 32.2 CD cord-005453-4057qib7 13242 13 % % NN cord-005453-4057qib7 13242 14 , , , cord-005453-4057qib7 13242 15 p=0.035 p=0.035 NNP cord-005453-4057qib7 13242 16 ) ) -RRB- cord-005453-4057qib7 13242 17 or or CC cord-005453-4057qib7 13242 18 BK BK NNP cord-005453-4057qib7 13242 19 virus virus NN cord-005453-4057qib7 13242 20 ( ( -LRB- cord-005453-4057qib7 13242 21 42.9 42.9 CD cord-005453-4057qib7 13242 22 % % NN cord-005453-4057qib7 13242 23 vs vs IN cord-005453-4057qib7 13242 24 6.8 6.8 CD cord-005453-4057qib7 13242 25 % % NN cord-005453-4057qib7 13242 26 , , , cord-005453-4057qib7 13242 27 p=0.002 p=0.002 NNP cord-005453-4057qib7 13242 28 ) ) -RRB- cord-005453-4057qib7 13242 29 infections infection NNS cord-005453-4057qib7 13242 30 . . . cord-005453-4057qib7 13243 1 In in IN cord-005453-4057qib7 13243 2 univariate univariate JJ cord-005453-4057qib7 13243 3 analysis analysis NN cord-005453-4057qib7 13243 4 , , , cord-005453-4057qib7 13243 5 patients patient NNS cord-005453-4057qib7 13243 6 who who WP cord-005453-4057qib7 13243 7 developed develop VBD cord-005453-4057qib7 13243 8 infection infection NN cord-005453-4057qib7 13243 9 were be VBD cord-005453-4057qib7 13243 10 also also RB cord-005453-4057qib7 13243 11 significantly significantly RB cord-005453-4057qib7 13243 12 older old JJR cord-005453-4057qib7 13243 13 at at IN cord-005453-4057qib7 13243 14 time time NN cord-005453-4057qib7 13243 15 of of IN cord-005453-4057qib7 13243 16 transplant transplant NN cord-005453-4057qib7 13243 17 ( ( -LRB- cord-005453-4057qib7 13243 18 respectively respectively RB cord-005453-4057qib7 13243 19 9.7 9.7 CD cord-005453-4057qib7 13243 20 vs vs IN cord-005453-4057qib7 13243 21 7.5 7.5 CD cord-005453-4057qib7 13243 22 years year NNS cord-005453-4057qib7 13243 23 old old JJ cord-005453-4057qib7 13243 24 , , , cord-005453-4057qib7 13243 25 p=0.016 p=0.016 RB cord-005453-4057qib7 13243 26 ) ) -RRB- cord-005453-4057qib7 13243 27 . . . cord-005453-4057qib7 13244 1 No no DT cord-005453-4057qib7 13244 2 severe severe JJ cord-005453-4057qib7 13244 3 sinusoidal sinusoidal JJ cord-005453-4057qib7 13244 4 obstruction obstruction NN cord-005453-4057qib7 13244 5 syndrome syndrome NN cord-005453-4057qib7 13244 6 was be VBD cord-005453-4057qib7 13244 7 observed observe VBN cord-005453-4057qib7 13244 8 . . . cord-005453-4057qib7 13245 1 Regarding regard VBG cord-005453-4057qib7 13245 2 long long JJ cord-005453-4057qib7 13245 3 - - HYPH cord-005453-4057qib7 13245 4 term term NN cord-005453-4057qib7 13245 5 toxicity toxicity NN cord-005453-4057qib7 13245 6 , , , cord-005453-4057qib7 13245 7 2 2 CD cord-005453-4057qib7 13245 8 patients patient NNS cord-005453-4057qib7 13245 9 presented present VBD cord-005453-4057qib7 13245 10 an an DT cord-005453-4057qib7 13245 11 extensive extensive JJ cord-005453-4057qib7 13245 12 chronic chronic JJ cord-005453-4057qib7 13245 13 GVHd GVHd NNS cord-005453-4057qib7 13245 14 , , , cord-005453-4057qib7 13245 15 they -PRON- PRP cord-005453-4057qib7 13245 16 were be VBD cord-005453-4057qib7 13245 17 both both RB cord-005453-4057qib7 13245 18 aged aged JJ cord-005453-4057qib7 13245 19 less less JJR cord-005453-4057qib7 13245 20 than than IN cord-005453-4057qib7 13245 21 13 13 CD cord-005453-4057qib7 13245 22 years year NNS cord-005453-4057qib7 13245 23 old old JJ cord-005453-4057qib7 13245 24 . . . cord-005453-4057qib7 13246 1 No no DT cord-005453-4057qib7 13246 2 cut cut VBN cord-005453-4057qib7 13246 3 - - HYPH cord-005453-4057qib7 13246 4 off off NN cord-005453-4057qib7 13246 5 of of IN cord-005453-4057qib7 13246 6 age age NN cord-005453-4057qib7 13246 7 could could MD cord-005453-4057qib7 13246 8 have have VB cord-005453-4057qib7 13246 9 been be VBN cord-005453-4057qib7 13246 10 defined define VBN cord-005453-4057qib7 13246 11 . . . cord-005453-4057qib7 13247 1 Conclusions conclusion NNS cord-005453-4057qib7 13247 2 : : : cord-005453-4057qib7 13248 1 This this DT cord-005453-4057qib7 13248 2 study study NN cord-005453-4057qib7 13248 3 confirms confirm VBZ cord-005453-4057qib7 13248 4 the the DT cord-005453-4057qib7 13248 5 excellent excellent JJ cord-005453-4057qib7 13248 6 results result NNS cord-005453-4057qib7 13248 7 of of IN cord-005453-4057qib7 13248 8 HSCT HSCT NNP cord-005453-4057qib7 13248 9 in in IN cord-005453-4057qib7 13248 10 SCD SCD NNP cord-005453-4057qib7 13248 11 , , , cord-005453-4057qib7 13248 12 with with IN cord-005453-4057qib7 13248 13 a a DT cord-005453-4057qib7 13248 14 5-year 5-year CD cord-005453-4057qib7 13248 15 event event NN cord-005453-4057qib7 13248 16 - - HYPH cord-005453-4057qib7 13248 17 free free JJ cord-005453-4057qib7 13248 18 survival survival NN cord-005453-4057qib7 13248 19 and and CC cord-005453-4057qib7 13248 20 overall overall JJ cord-005453-4057qib7 13248 21 survival survival NN cord-005453-4057qib7 13248 22 of of IN cord-005453-4057qib7 13248 23 100 100 CD cord-005453-4057qib7 13248 24 % % NN cord-005453-4057qib7 13248 25 . . . cord-005453-4057qib7 13249 1 An an DT cord-005453-4057qib7 13249 2 older old JJR cord-005453-4057qib7 13249 3 age age NN cord-005453-4057qib7 13249 4 at at IN cord-005453-4057qib7 13249 5 transplant transplant NN cord-005453-4057qib7 13249 6 seems seem VBZ cord-005453-4057qib7 13249 7 to to TO cord-005453-4057qib7 13249 8 be be VB cord-005453-4057qib7 13249 9 associated associate VBN cord-005453-4057qib7 13249 10 with with IN cord-005453-4057qib7 13249 11 more more RBR cord-005453-4057qib7 13249 12 frequent frequent JJ cord-005453-4057qib7 13249 13 severe severe JJ cord-005453-4057qib7 13249 14 acute acute JJ cord-005453-4057qib7 13249 15 toxicity toxicity NN cord-005453-4057qib7 13249 16 . . . cord-005453-4057qib7 13250 1 These these DT cord-005453-4057qib7 13250 2 results result NNS cord-005453-4057qib7 13250 3 are be VBP cord-005453-4057qib7 13250 4 consistent consistent JJ cord-005453-4057qib7 13250 5 with with IN cord-005453-4057qib7 13250 6 previous previous JJ cord-005453-4057qib7 13250 7 studies study NNS cord-005453-4057qib7 13250 8 and and CC cord-005453-4057qib7 13250 9 suggest suggest VBP cord-005453-4057qib7 13250 10 that that IN cord-005453-4057qib7 13250 11 HSCT HSCT NNP cord-005453-4057qib7 13250 12 should should MD cord-005453-4057qib7 13250 13 be be VB cord-005453-4057qib7 13250 14 performed perform VBN cord-005453-4057qib7 13250 15 as as RB cord-005453-4057qib7 13250 16 soon soon RB cord-005453-4057qib7 13250 17 as as IN cord-005453-4057qib7 13250 18 possible possible JJ cord-005453-4057qib7 13250 19 , , , cord-005453-4057qib7 13250 20 without without IN cord-005453-4057qib7 13250 21 any any DT cord-005453-4057qib7 13250 22 defined define VBN cord-005453-4057qib7 13250 23 " " `` cord-005453-4057qib7 13250 24 best good JJS cord-005453-4057qib7 13250 25 age age NN cord-005453-4057qib7 13250 26 " " '' cord-005453-4057qib7 13250 27 . . . cord-005453-4057qib7 13251 1 Prospective prospective JJ cord-005453-4057qib7 13251 2 studies study NNS cord-005453-4057qib7 13251 3 are be VBP cord-005453-4057qib7 13251 4 needed need VBN cord-005453-4057qib7 13251 5 , , , cord-005453-4057qib7 13251 6 in in IN cord-005453-4057qib7 13251 7 order order NN cord-005453-4057qib7 13251 8 to to TO cord-005453-4057qib7 13251 9 define define VB cord-005453-4057qib7 13251 10 the the DT cord-005453-4057qib7 13251 11 place place NN cord-005453-4057qib7 13251 12 of of IN cord-005453-4057qib7 13251 13 each each DT cord-005453-4057qib7 13251 14 therapeutic therapeutic JJ cord-005453-4057qib7 13251 15 in in IN cord-005453-4057qib7 13251 16 SCD SCD NNP cord-005453-4057qib7 13251 17 , , , cord-005453-4057qib7 13251 18 with with IN cord-005453-4057qib7 13251 19 the the DT cord-005453-4057qib7 13251 20 aim aim NN cord-005453-4057qib7 13251 21 of of IN cord-005453-4057qib7 13251 22 reducing reduce VBG cord-005453-4057qib7 13251 23 treatment treatment NN cord-005453-4057qib7 13251 24 - - HYPH cord-005453-4057qib7 13251 25 related relate VBN cord-005453-4057qib7 13251 26 toxicity toxicity NN cord-005453-4057qib7 13251 27 and and CC cord-005453-4057qib7 13251 28 developing develop VBG cord-005453-4057qib7 13251 29 alternative alternative JJ cord-005453-4057qib7 13251 30 strategies strategy NNS cord-005453-4057qib7 13251 31 for for IN cord-005453-4057qib7 13251 32 patients patient NNS cord-005453-4057qib7 13251 33 without without IN cord-005453-4057qib7 13251 34 match match NN cord-005453-4057qib7 13251 35 sibling sibling NN cord-005453-4057qib7 13251 36 donor donor NN cord-005453-4057qib7 13251 37 . . . cord-005453-4057qib7 13252 1 Disclosure disclosure NN cord-005453-4057qib7 13252 2 : : : cord-005453-4057qib7 13252 3 nothing nothing NN cord-005453-4057qib7 13252 4 to to TO cord-005453-4057qib7 13252 5 declare declare VB cord-005453-4057qib7 13252 6 P599 p599 CD cord-005453-4057qib7 13252 7 New new JJ cord-005453-4057qib7 13252 8 insights insight NNS cord-005453-4057qib7 13252 9 into into IN cord-005453-4057qib7 13252 10 risk risk NN cord-005453-4057qib7 13252 11 factors factor NNS cord-005453-4057qib7 13252 12 for for IN cord-005453-4057qib7 13252 13 transplant transplant NN cord-005453-4057qib7 13252 14 - - HYPH cord-005453-4057qib7 13252 15 associated associate VBN cord-005453-4057qib7 13252 16 thrombotic thrombotic JJ cord-005453-4057qib7 13252 17 microangiopathy microangiopathy NNP cord-005453-4057qib7 13252 18 ( ( -LRB- cord-005453-4057qib7 13252 19 TA TA NNP cord-005453-4057qib7 13252 20 - - HYPH cord-005453-4057qib7 13252 21 TMA TMA NNP cord-005453-4057qib7 13252 22 ) ) -RRB- cord-005453-4057qib7 13252 23 in in IN cord-005453-4057qib7 13252 24 paediatric paediatric JJ cord-005453-4057qib7 13252 25 HSCT HSCT NNP cord-005453-4057qib7 13252 26 ( ( -LRB- cord-005453-4057qib7 13252 27 n=170 n=170 NNP cord-005453-4057qib7 13252 28 ) ) -RRB- cord-005453-4057qib7 13252 29 was be VBD cord-005453-4057qib7 13252 30 associated associate VBN cord-005453-4057qib7 13252 31 with with IN cord-005453-4057qib7 13252 32 TA TA NNP cord-005453-4057qib7 13252 33 - - HYPH cord-005453-4057qib7 13252 34 TMA TMA NNP cord-005453-4057qib7 13252 35 in in IN cord-005453-4057qib7 13252 36 1 1 CD cord-005453-4057qib7 13252 37 % % NN cord-005453-4057qib7 13252 38 vs vs IN cord-005453-4057qib7 13252 39 5.8 5.8 CD cord-005453-4057qib7 13252 40 % % NN cord-005453-4057qib7 13252 41 vs vs IN cord-005453-4057qib7 13252 42 7.7 7.7 CD cord-005453-4057qib7 13252 43 % % NN cord-005453-4057qib7 13252 44 respectively respectively RB cord-005453-4057qib7 13252 45 ( ( -LRB- cord-005453-4057qib7 13252 46 p=0.067 p=0.067 JJ cord-005453-4057qib7 13252 47 ) ) -RRB- cord-005453-4057qib7 13252 48 . . . cord-005453-4057qib7 13253 1 The the DT cord-005453-4057qib7 13253 2 presence presence NN cord-005453-4057qib7 13253 3 of of IN cord-005453-4057qib7 13253 4 comorbidities comorbiditie NNS cord-005453-4057qib7 13253 5 at at IN cord-005453-4057qib7 13253 6 D0 D0 NNP cord-005453-4057qib7 13253 7 ( ( -LRB- cord-005453-4057qib7 13253 8 n=86 n=86 NNP cord-005453-4057qib7 13253 9 ) ) -RRB- cord-005453-4057qib7 13253 10 was be VBD cord-005453-4057qib7 13253 11 significantly significantly RB cord-005453-4057qib7 13253 12 associated associate VBN cord-005453-4057qib7 13253 13 with with IN cord-005453-4057qib7 13253 14 an an DT cord-005453-4057qib7 13253 15 increased increase VBN cord-005453-4057qib7 13253 16 risk risk NN cord-005453-4057qib7 13253 17 of of IN cord-005453-4057qib7 13253 18 TA TA NNP cord-005453-4057qib7 13253 19 - - HYPH cord-005453-4057qib7 13253 20 TMA TMA NNP cord-005453-4057qib7 13253 21 10.4 10.4 CD cord-005453-4057qib7 13253 22 % % NN cord-005453-4057qib7 13253 23 vs3.7 vs3.7 NN cord-005453-4057qib7 13253 24 % % NN cord-005453-4057qib7 13253 25 in in IN cord-005453-4057qib7 13253 26 absence absence NN cord-005453-4057qib7 13253 27 of of IN cord-005453-4057qib7 13253 28 co co NN cord-005453-4057qib7 13253 29 - - NN cord-005453-4057qib7 13253 30 morbidity morbidity JJ cord-005453-4057qib7 13253 31 ( ( -LRB- cord-005453-4057qib7 13253 32 n=320 n=320 UH cord-005453-4057qib7 13253 33 ) ) -RRB- cord-005453-4057qib7 13253 34 ; ; : cord-005453-4057qib7 13254 1 p=0.032 p=0.032 NNPS cord-005453-4057qib7 13254 2 . . . cord-005453-4057qib7 13255 1 Use Use NNP cord-005453-4057qib7 13255 2 of of IN cord-005453-4057qib7 13255 3 CSA CSA NNP cord-005453-4057qib7 13255 4 / / SYM cord-005453-4057qib7 13255 5 Tac Tac NNP cord-005453-4057qib7 13255 6 - - HYPH cord-005453-4057qib7 13255 7 based base VBN cord-005453-4057qib7 13255 8 GvHD GvHD NNP cord-005453-4057qib7 13255 9 prophylaxis prophylaxis NN cord-005453-4057qib7 13255 10 was be VBD cord-005453-4057qib7 13255 11 associated associate VBN cord-005453-4057qib7 13255 12 with with IN cord-005453-4057qib7 13255 13 less less JJR cord-005453-4057qib7 13255 14 TA TA NNP cord-005453-4057qib7 13255 15 - - HYPH cord-005453-4057qib7 13255 16 TMA TMA NNP cord-005453-4057qib7 13255 17 with with IN cord-005453-4057qib7 13255 18 an an DT cord-005453-4057qib7 13255 19 incidence incidence NN cord-005453-4057qib7 13255 20 of of IN cord-005453-4057qib7 13255 21 4 4 CD cord-005453-4057qib7 13255 22 % % NN cord-005453-4057qib7 13255 23 vs vs IN cord-005453-4057qib7 13255 24 13 13 CD cord-005453-4057qib7 13255 25 % % NN cord-005453-4057qib7 13255 26 if if IN cord-005453-4057qib7 13255 27 these these DT cord-005453-4057qib7 13255 28 agents agent NNS cord-005453-4057qib7 13255 29 were be VBD cord-005453-4057qib7 13255 30 not not RB cord-005453-4057qib7 13255 31 included include VBN cord-005453-4057qib7 13255 32 ( ( -LRB- cord-005453-4057qib7 13255 33 p=0.01 p=0.01 NNP cord-005453-4057qib7 13255 34 ) ) -RRB- cord-005453-4057qib7 13255 35 . . . cord-005453-4057qib7 13256 1 In in IN cord-005453-4057qib7 13256 2 univariate univariate JJ cord-005453-4057qib7 13256 3 analysis analysis NN cord-005453-4057qib7 13256 4 TA TA NNP cord-005453-4057qib7 13256 5 - - HYPH cord-005453-4057qib7 13256 6 TMA TMA NNP cord-005453-4057qib7 13256 7 was be VBD cord-005453-4057qib7 13256 8 significantly significantly RB cord-005453-4057qib7 13256 9 higher high JJR cord-005453-4057qib7 13256 10 among among IN cord-005453-4057qib7 13256 11 patients patient NNS cord-005453-4057qib7 13256 12 with with IN cord-005453-4057qib7 13256 13 aGvHD agvhd NN cord-005453-4057qib7 13256 14 grade grade NNP cord-005453-4057qib7 13256 15 II II NNP cord-005453-4057qib7 13256 16 - - HYPH cord-005453-4057qib7 13256 17 IV IV NNP cord-005453-4057qib7 13256 18 ( ( -LRB- cord-005453-4057qib7 13256 19 12/138 12/138 CD cord-005453-4057qib7 13256 20 ; ; : cord-005453-4057qib7 13256 21 8.6 8.6 CD cord-005453-4057qib7 13256 22 % % NN cord-005453-4057qib7 13256 23 ) ) -RRB- cord-005453-4057qib7 13256 24 vs vs IN cord-005453-4057qib7 13256 25 Grade Grade NNP cord-005453-4057qib7 13256 26 0-I 0-i CD cord-005453-4057qib7 13257 1 ( ( -LRB- cord-005453-4057qib7 13257 2 6/227;2.6 6/227;2.6 CD cord-005453-4057qib7 13257 3 % % NN cord-005453-4057qib7 13257 4 ) ) -RRB- cord-005453-4057qib7 13257 5 ( ( -LRB- cord-005453-4057qib7 13257 6 p=0.01 p=0.01 NNP cord-005453-4057qib7 13257 7 ) ) -RRB- cord-005453-4057qib7 13257 8 . . . cord-005453-4057qib7 13258 1 PRES PRES NNP cord-005453-4057qib7 13258 2 was be VBD cord-005453-4057qib7 13258 3 recorded record VBN cord-005453-4057qib7 13258 4 among among IN cord-005453-4057qib7 13258 5 10 10 CD cord-005453-4057qib7 13258 6 cases case NNS cord-005453-4057qib7 13258 7 and and CC cord-005453-4057qib7 13258 8 50 50 CD cord-005453-4057qib7 13258 9 % % NN cord-005453-4057qib7 13258 10 of of IN cord-005453-4057qib7 13258 11 them -PRON- PRP cord-005453-4057qib7 13258 12 developed develop VBD cord-005453-4057qib7 13258 13 TA TA NNP cord-005453-4057qib7 13258 14 - - HYPH cord-005453-4057qib7 13258 15 TMA TMA NNP cord-005453-4057qib7 13258 16 . . . cord-005453-4057qib7 13259 1 Two two CD cord-005453-4057qib7 13259 2 out out IN cord-005453-4057qib7 13259 3 of of IN cord-005453-4057qib7 13259 4 the the DT cord-005453-4057qib7 13259 5 21 21 CD cord-005453-4057qib7 13259 6 patients patient NNS cord-005453-4057qib7 13259 7 with with IN cord-005453-4057qib7 13259 8 TA TA NNP cord-005453-4057qib7 13259 9 - - HYPH cord-005453-4057qib7 13259 10 TMA TMA NNP cord-005453-4057qib7 13259 11 had have VBD cord-005453-4057qib7 13259 12 pathological pathological JJ cord-005453-4057qib7 13259 13 gene gene NN cord-005453-4057qib7 13259 14 mutations mutation NNS cord-005453-4057qib7 13259 15 in in IN cord-005453-4057qib7 13259 16 their -PRON- PRP$ cord-005453-4057qib7 13259 17 complement complement NN cord-005453-4057qib7 13259 18 pathway pathway NN cord-005453-4057qib7 13259 19 . . . cord-005453-4057qib7 13260 1 On on IN cord-005453-4057qib7 13260 2 multivariate multivariate JJ cord-005453-4057qib7 13260 3 analysis analysis NN cord-005453-4057qib7 13260 4 the the DT cord-005453-4057qib7 13260 5 presence presence NN cord-005453-4057qib7 13260 6 of of IN cord-005453-4057qib7 13260 7 active active JJ cord-005453-4057qib7 13260 8 comorbidity comorbidity NN cord-005453-4057qib7 13260 9 was be VBD cord-005453-4057qib7 13260 10 a a DT cord-005453-4057qib7 13260 11 risk risk NN cord-005453-4057qib7 13260 12 factor factor NN cord-005453-4057qib7 13260 13 for for IN cord-005453-4057qib7 13260 14 TA TA NNP cord-005453-4057qib7 13260 15 - - HYPH cord-005453-4057qib7 13260 16 TMA TMA NNP cord-005453-4057qib7 13260 17 ( ( -LRB- cord-005453-4057qib7 13260 18 OR:6.6 OR:6.6 NNP cord-005453-4057qib7 13260 19 ; ; : cord-005453-4057qib7 13260 20 95 95 CD cord-005453-4057qib7 13260 21 % % NN cord-005453-4057qib7 13260 22 CI:1.1 ci:1.1 NN cord-005453-4057qib7 13260 23 - - HYPH cord-005453-4057qib7 13260 24 37.6 37.6 CD cord-005453-4057qib7 13260 25 ; ; : cord-005453-4057qib7 13260 26 p=0.032 p=0.032 ADD cord-005453-4057qib7 13260 27 ) ) -RRB- cord-005453-4057qib7 13261 1 while while IN cord-005453-4057qib7 13261 2 the the DT cord-005453-4057qib7 13261 3 use use NN cord-005453-4057qib7 13261 4 of of IN cord-005453-4057qib7 13261 5 CSA CSA NNP cord-005453-4057qib7 13261 6 / / SYM cord-005453-4057qib7 13261 7 Tac Tac NNP cord-005453-4057qib7 13261 8 - - HYPH cord-005453-4057qib7 13261 9 based base VBN cord-005453-4057qib7 13261 10 GvHD GvHD NNP cord-005453-4057qib7 13261 11 prophylaxis prophylaxis NN cord-005453-4057qib7 13261 12 did do VBD cord-005453-4057qib7 13261 13 not not RB cord-005453-4057qib7 13261 14 increase increase VB cord-005453-4057qib7 13261 15 the the DT cord-005453-4057qib7 13261 16 risk risk NN cord-005453-4057qib7 13261 17 for for IN cord-005453-4057qib7 13261 18 TA TA NNP cord-005453-4057qib7 13261 19 - - HYPH cord-005453-4057qib7 13261 20 TMA TMA NNP cord-005453-4057qib7 13261 21 ( ( -LRB- cord-005453-4057qib7 13261 22 OR:0.04 OR:0.04 NNP cord-005453-4057qib7 13261 23 ; ; : cord-005453-4057qib7 13261 24 CI:0.004 ci:0.004 NN cord-005453-4057qib7 13261 25 - - HYPH cord-005453-4057qib7 13261 26 0.39 0.39 CD cord-005453-4057qib7 13261 27 ; ; : cord-005453-4057qib7 13261 28 p=0.005 p=0.005 NNP cord-005453-4057qib7 13261 29 ) ) -RRB- cord-005453-4057qib7 13261 30 . . . cord-005453-4057qib7 13262 1 In in IN cord-005453-4057qib7 13262 2 the the DT cord-005453-4057qib7 13262 3 presence presence NN cord-005453-4057qib7 13262 4 of of IN cord-005453-4057qib7 13262 5 comorbidities comorbiditie NNS cord-005453-4057qib7 13262 6 the the DT cord-005453-4057qib7 13262 7 use use NN cord-005453-4057qib7 13262 8 of of IN cord-005453-4057qib7 13262 9 Defibrotide Defibrotide NNP cord-005453-4057qib7 13262 10 as as IN cord-005453-4057qib7 13262 11 prophylaxis prophylaxis NN cord-005453-4057qib7 13262 12 or or CC cord-005453-4057qib7 13262 13 therapy therapy NN cord-005453-4057qib7 13262 14 for for IN cord-005453-4057qib7 13262 15 VOD VOD NNP cord-005453-4057qib7 13262 16 ( ( -LRB- cord-005453-4057qib7 13262 17 n=86 n=86 NNP cord-005453-4057qib7 13262 18 ) ) -RRB- cord-005453-4057qib7 13262 19 was be VBD cord-005453-4057qib7 13262 20 associated associate VBN cord-005453-4057qib7 13262 21 with with IN cord-005453-4057qib7 13262 22 a a DT cord-005453-4057qib7 13262 23 drop drop NN cord-005453-4057qib7 13262 24 in in IN cord-005453-4057qib7 13262 25 the the DT cord-005453-4057qib7 13262 26 incidence incidence NN cord-005453-4057qib7 13262 27 of of IN cord-005453-4057qib7 13262 28 TA TA NNP cord-005453-4057qib7 13262 29 - - HYPH cord-005453-4057qib7 13262 30 TMA TMA NNP cord-005453-4057qib7 13262 31 from from IN cord-005453-4057qib7 13262 32 12 12 CD cord-005453-4057qib7 13262 33 % % NN cord-005453-4057qib7 13262 34 ( ( -LRB- cord-005453-4057qib7 13262 35 9/79 9/79 CD cord-005453-4057qib7 13262 36 ) ) -RRB- cord-005453-4057qib7 13262 37 in in IN cord-005453-4057qib7 13262 38 absence absence NN cord-005453-4057qib7 13262 39 of of IN cord-005453-4057qib7 13262 40 Defibrotide Defibrotide NNP cord-005453-4057qib7 13262 41 to to IN cord-005453-4057qib7 13262 42 0 0 CD cord-005453-4057qib7 13262 43 % % NN cord-005453-4057qib7 13262 44 ( ( -LRB- cord-005453-4057qib7 13262 45 0/7 0/7 CD cord-005453-4057qib7 13262 46 ) ) -RRB- cord-005453-4057qib7 13262 47 . . . cord-005453-4057qib7 13263 1 2-year 2-year CD cord-005453-4057qib7 13263 2 overall overall JJ cord-005453-4057qib7 13263 3 survival survival NN cord-005453-4057qib7 13263 4 was be VBD cord-005453-4057qib7 13263 5 significantly significantly RB cord-005453-4057qib7 13263 6 lower low JJR cord-005453-4057qib7 13263 7 among among IN cord-005453-4057qib7 13263 8 TA TA NNP cord-005453-4057qib7 13263 9 - - HYPH cord-005453-4057qib7 13263 10 TMA TMA NNP cord-005453-4057qib7 13263 11 cases case NNS cord-005453-4057qib7 13263 12 ( ( -LRB- cord-005453-4057qib7 13263 13 58 58 CD cord-005453-4057qib7 13263 14 % % NN cord-005453-4057qib7 13263 15 ) ) -RRB- cord-005453-4057qib7 13263 16 in in IN cord-005453-4057qib7 13263 17 comparison comparison NN cord-005453-4057qib7 13263 18 to to IN cord-005453-4057qib7 13263 19 81.5 81.5 CD cord-005453-4057qib7 13263 20 % % NN cord-005453-4057qib7 13263 21 in in IN cord-005453-4057qib7 13263 22 absence absence NN cord-005453-4057qib7 13263 23 of of IN cord-005453-4057qib7 13263 24 TA TA NNP cord-005453-4057qib7 13263 25 - - HYPH cord-005453-4057qib7 13263 26 TMA TMA NNP cord-005453-4057qib7 13263 27 ( ( -LRB- cord-005453-4057qib7 13263 28 p=0.001 p=0.001 NNP cord-005453-4057qib7 13263 29 ) ) -RRB- cord-005453-4057qib7 13264 1 ( ( -LRB- cord-005453-4057qib7 13264 2 figure figure NN cord-005453-4057qib7 13264 3 1 1 CD cord-005453-4057qib7 13264 4 ) ) -RRB- cord-005453-4057qib7 13264 5 . . . cord-005453-4057qib7 13265 1 Conclusions conclusion NNS cord-005453-4057qib7 13265 2 : : : cord-005453-4057qib7 13266 1 Active active JJ cord-005453-4057qib7 13266 2 co co NN cord-005453-4057qib7 13266 3 - - NN cord-005453-4057qib7 13266 4 morbidity morbidity NN cord-005453-4057qib7 13266 5 is be VBZ cord-005453-4057qib7 13266 6 a a DT cord-005453-4057qib7 13266 7 significant significant JJ cord-005453-4057qib7 13266 8 risk risk NN cord-005453-4057qib7 13266 9 factor factor NN cord-005453-4057qib7 13266 10 for for IN cord-005453-4057qib7 13266 11 TA TA NNP cord-005453-4057qib7 13266 12 - - HYPH cord-005453-4057qib7 13266 13 TMA TMA NNP cord-005453-4057qib7 13266 14 . . . cord-005453-4057qib7 13267 1 Use Use NNP cord-005453-4057qib7 13267 2 of of IN cord-005453-4057qib7 13267 3 Defibrotide Defibrotide NNP cord-005453-4057qib7 13267 4 prophylaxis prophylaxis NN cord-005453-4057qib7 13267 5 in in IN cord-005453-4057qib7 13267 6 patients patient NNS cord-005453-4057qib7 13267 7 with with IN cord-005453-4057qib7 13267 8 co co NNS cord-005453-4057qib7 13267 9 - - NNS cord-005453-4057qib7 13267 10 morbidities morbidity NNS cord-005453-4057qib7 13267 11 at at IN cord-005453-4057qib7 13267 12 the the DT cord-005453-4057qib7 13267 13 time time NN cord-005453-4057qib7 13267 14 of of IN cord-005453-4057qib7 13267 15 HSCT HSCT NNP cord-005453-4057qib7 13267 16 might may MD cord-005453-4057qib7 13267 17 offer offer VB cord-005453-4057qib7 13267 18 protection protection NN cord-005453-4057qib7 13267 19 against against IN cord-005453-4057qib7 13267 20 TA TA NNP cord-005453-4057qib7 13267 21 - - HYPH cord-005453-4057qib7 13267 22 TMA TMA NNP cord-005453-4057qib7 13267 23 . . . cord-005453-4057qib7 13268 1 Surprisingly surprisingly RB cord-005453-4057qib7 13268 2 the the DT cord-005453-4057qib7 13268 3 use use NN cord-005453-4057qib7 13268 4 of of IN cord-005453-4057qib7 13268 5 CSA CSA NNP cord-005453-4057qib7 13268 6 / / SYM cord-005453-4057qib7 13268 7 Tac Tac NNP cord-005453-4057qib7 13268 8 based base VBN cord-005453-4057qib7 13268 9 GvHD GvHD NNP cord-005453-4057qib7 13268 10 prophylaxis prophylaxis NN cord-005453-4057qib7 13268 11 is be VBZ cord-005453-4057qib7 13268 12 not not RB cord-005453-4057qib7 13268 13 a a DT cord-005453-4057qib7 13268 14 risk risk NN cord-005453-4057qib7 13268 15 factor factor NN cord-005453-4057qib7 13268 16 for for IN cord-005453-4057qib7 13268 17 TA TA NNP cord-005453-4057qib7 13268 18 - - HYPH cord-005453-4057qib7 13268 19 TMA TMA NNP cord-005453-4057qib7 13268 20 probably probably RB cord-005453-4057qib7 13268 21 through through IN cord-005453-4057qib7 13268 22 limiting limit VBG cord-005453-4057qib7 13268 23 the the DT cord-005453-4057qib7 13268 24 development development NN cord-005453-4057qib7 13268 25 of of IN cord-005453-4057qib7 13268 26 high high JJ cord-005453-4057qib7 13268 27 grades grade NNS cord-005453-4057qib7 13268 28 aGvHD agvhd NN cord-005453-4057qib7 13268 29 . . . cord-005453-4057qib7 13269 1 The the DT cord-005453-4057qib7 13269 2 association association NN cord-005453-4057qib7 13269 3 between between IN cord-005453-4057qib7 13269 4 PRES PRES NNP cord-005453-4057qib7 13269 5 and and CC cord-005453-4057qib7 13269 6 TA TA NNP cord-005453-4057qib7 13269 7 - - HYPH cord-005453-4057qib7 13269 8 TMA TMA NNP cord-005453-4057qib7 13269 9 suggests suggest VBZ cord-005453-4057qib7 13269 10 a a DT cord-005453-4057qib7 13269 11 common common JJ cord-005453-4057qib7 13269 12 pathway pathway NN cord-005453-4057qib7 13269 13 of of IN cord-005453-4057qib7 13269 14 endothelial endothelial JJ cord-005453-4057qib7 13269 15 damage damage NN cord-005453-4057qib7 13269 16 Background background NN cord-005453-4057qib7 13269 17 : : : cord-005453-4057qib7 13270 1 Gonadal gonadal JJ cord-005453-4057qib7 13270 2 impairment impairment NN cord-005453-4057qib7 13270 3 is be VBZ cord-005453-4057qib7 13270 4 a a DT cord-005453-4057qib7 13270 5 severe severe JJ cord-005453-4057qib7 13270 6 late late JJ cord-005453-4057qib7 13270 7 effect effect NN cord-005453-4057qib7 13270 8 of of IN cord-005453-4057qib7 13270 9 myeloablative myeloablative JJ cord-005453-4057qib7 13270 10 conditioning conditioning NN cord-005453-4057qib7 13270 11 regimes regime NNS cord-005453-4057qib7 13270 12 with with IN cord-005453-4057qib7 13270 13 significant significant JJ cord-005453-4057qib7 13270 14 impact impact NN cord-005453-4057qib7 13270 15 on on IN cord-005453-4057qib7 13270 16 quality quality NN cord-005453-4057qib7 13270 17 of of IN cord-005453-4057qib7 13270 18 life life NN cord-005453-4057qib7 13270 19 of of IN cord-005453-4057qib7 13270 20 cancer cancer NN cord-005453-4057qib7 13270 21 survivors survivor NNS cord-005453-4057qib7 13270 22 . . . cord-005453-4057qib7 13271 1 The the DT cord-005453-4057qib7 13271 2 aim aim NN cord-005453-4057qib7 13271 3 of of IN cord-005453-4057qib7 13271 4 this this DT cord-005453-4057qib7 13271 5 study study NN cord-005453-4057qib7 13271 6 was be VBD cord-005453-4057qib7 13271 7 to to TO cord-005453-4057qib7 13271 8 analyze analyze VB cord-005453-4057qib7 13271 9 gonadal gonadal JJ cord-005453-4057qib7 13271 10 function function NN cord-005453-4057qib7 13271 11 after after IN cord-005453-4057qib7 13271 12 Busulfan Busulfan NNP cord-005453-4057qib7 13271 13 ( ( -LRB- cord-005453-4057qib7 13271 14 Bu Bu NNP cord-005453-4057qib7 13271 15 ) ) -RRB- cord-005453-4057qib7 13271 16 or or CC cord-005453-4057qib7 13271 17 Treosulfan Treosulfan NNP cord-005453-4057qib7 13271 18 ( ( -LRB- cord-005453-4057qib7 13271 19 Treo Treo NNP cord-005453-4057qib7 13271 20 ) ) -RRB- cord-005453-4057qib7 13271 21 containing contain VBG cord-005453-4057qib7 13271 22 regimens regimen NNS cord-005453-4057qib7 13271 23 with with IN cord-005453-4057qib7 13271 24 regard regard NN cord-005453-4057qib7 13271 25 to to IN cord-005453-4057qib7 13271 26 pubertal pubertal JJ cord-005453-4057qib7 13271 27 stage stage NN cord-005453-4057qib7 13271 28 . . . cord-005453-4057qib7 13272 1 Methods method NNS cord-005453-4057qib7 13272 2 : : : cord-005453-4057qib7 13272 3 This this DT cord-005453-4057qib7 13272 4 was be VBD cord-005453-4057qib7 13272 5 a a DT cord-005453-4057qib7 13272 6 retrospective retrospective JJ cord-005453-4057qib7 13272 7 , , , cord-005453-4057qib7 13272 8 multicenter multicenter JJ cord-005453-4057qib7 13272 9 study study NN cord-005453-4057qib7 13272 10 involving involve VBG cord-005453-4057qib7 13272 11 patients patient NNS cord-005453-4057qib7 13272 12 treated treat VBN cord-005453-4057qib7 13272 13 in in IN cord-005453-4057qib7 13272 14 pediatric pediatric JJ cord-005453-4057qib7 13272 15 EBMT EBMT NNP cord-005453-4057qib7 13272 16 centers center NNS cord-005453-4057qib7 13272 17 between between IN cord-005453-4057qib7 13272 18 1992 1992 CD cord-005453-4057qib7 13272 19 - - SYM cord-005453-4057qib7 13272 20 2012 2012 CD cord-005453-4057qib7 13272 21 . . . cord-005453-4057qib7 13273 1 Patients patient NNS cord-005453-4057qib7 13273 2 receiving receive VBG cord-005453-4057qib7 13273 3 myeloablative myeloablative JJ cord-005453-4057qib7 13273 4 doses dose NNS cord-005453-4057qib7 13273 5 of of IN cord-005453-4057qib7 13273 6 Bu Bu NNP cord-005453-4057qib7 13273 7 or or CC cord-005453-4057qib7 13273 8 Treo Treo NNP cord-005453-4057qib7 13273 9 as as IN cord-005453-4057qib7 13273 10 part part NN cord-005453-4057qib7 13273 11 of of IN cord-005453-4057qib7 13273 12 HSCT HSCT NNP cord-005453-4057qib7 13273 13 conditioning conditioning NN cord-005453-4057qib7 13273 14 were be VBD cord-005453-4057qib7 13273 15 eligible eligible JJ cord-005453-4057qib7 13273 16 for for IN cord-005453-4057qib7 13273 17 inclusion inclusion NN cord-005453-4057qib7 13273 18 . . . cord-005453-4057qib7 13274 1 Analysis analysis NN cord-005453-4057qib7 13274 2 was be VBD cord-005453-4057qib7 13274 3 conducted conduct VBN cord-005453-4057qib7 13274 4 in in IN cord-005453-4057qib7 13274 5 two two CD cord-005453-4057qib7 13274 6 groups group NNS cord-005453-4057qib7 13274 7 according accord VBG cord-005453-4057qib7 13274 8 to to IN cord-005453-4057qib7 13274 9 pubertal pubertal JJ cord-005453-4057qib7 13274 10 status status NN cord-005453-4057qib7 13274 11 at at IN cord-005453-4057qib7 13274 12 time time NN cord-005453-4057qib7 13274 13 of of IN cord-005453-4057qib7 13274 14 HSCT HSCT NNP cord-005453-4057qib7 13274 15 . . . cord-005453-4057qib7 13275 1 Results result NNS cord-005453-4057qib7 13275 2 : : : cord-005453-4057qib7 13276 1 137 137 CD cord-005453-4057qib7 13276 2 patients patient NNS cord-005453-4057qib7 13276 3 ( ( -LRB- cord-005453-4057qib7 13276 4 pts pt NNS cord-005453-4057qib7 13276 5 ) ) -RRB- cord-005453-4057qib7 13276 6 were be VBD cord-005453-4057qib7 13276 7 treated treat VBN cord-005453-4057qib7 13276 8 in in IN cord-005453-4057qib7 13276 9 25 25 CD cord-005453-4057qib7 13276 10 pediatric pediatric JJ cord-005453-4057qib7 13276 11 EBMT EBMT NNP cord-005453-4057qib7 13276 12 with with IN cord-005453-4057qib7 13276 13 Bu Bu NNP cord-005453-4057qib7 13276 14 or or CC cord-005453-4057qib7 13276 15 Treo Treo NNP cord-005453-4057qib7 13276 16 before before IN cord-005453-4057qib7 13276 17 allogeneic allogeneic NN cord-005453-4057qib7 13276 18 HSCT HSCT NNP cord-005453-4057qib7 13276 19 . . . cord-005453-4057qib7 13277 1 The the DT cord-005453-4057qib7 13277 2 median median JJ cord-005453-4057qib7 13277 3 age age NN cord-005453-4057qib7 13277 4 at at IN cord-005453-4057qib7 13277 5 transplant transplant NN cord-005453-4057qib7 13277 6 was be VBD cord-005453-4057qib7 13277 7 11.04 11.04 CD cord-005453-4057qib7 13277 8 years year NNS cord-005453-4057qib7 13278 1 ( ( -LRB- cord-005453-4057qib7 13278 2 range range NNP cord-005453-4057qib7 13278 3 5 5 CD cord-005453-4057qib7 13278 4 - - SYM cord-005453-4057qib7 13278 5 18 18 CD cord-005453-4057qib7 13278 6 ) ) -RRB- cord-005453-4057qib7 13278 7 ; ; : cord-005453-4057qib7 13278 8 89/ 89/ LS cord-005453-4057qib7 13278 9 137 137 CD cord-005453-4057qib7 13278 10 ( ( -LRB- cord-005453-4057qib7 13278 11 65 65 CD cord-005453-4057qib7 13278 12 % % NN cord-005453-4057qib7 13278 13 ) ) -RRB- cord-005453-4057qib7 13278 14 were be VBD cord-005453-4057qib7 13278 15 males male NNS cord-005453-4057qib7 13278 16 ( ( -LRB- cord-005453-4057qib7 13278 17 m m NNP cord-005453-4057qib7 13278 18 ) ) -RRB- cord-005453-4057qib7 13278 19 , , , cord-005453-4057qib7 13278 20 48/137 48/137 CD cord-005453-4057qib7 13278 21 ( ( -LRB- cord-005453-4057qib7 13278 22 35 35 CD cord-005453-4057qib7 13278 23 % % NN cord-005453-4057qib7 13278 24 ) ) -RRB- cord-005453-4057qib7 13278 25 were be VBD cord-005453-4057qib7 13278 26 females female NNS cord-005453-4057qib7 13278 27 ( ( -LRB- cord-005453-4057qib7 13278 28 f f NNP cord-005453-4057qib7 13278 29 ) ) -RRB- cord-005453-4057qib7 13278 30 . . . cord-005453-4057qib7 13279 1 89/137 89/137 CD cord-005453-4057qib7 13280 1 ( ( -LRB- cord-005453-4057qib7 13280 2 65 65 CD cord-005453-4057qib7 13280 3 % % NN cord-005453-4057qib7 13280 4 ) ) -RRB- cord-005453-4057qib7 13280 5 pts pt NNS cord-005453-4057qib7 13280 6 were be VBD cord-005453-4057qib7 13280 7 pre pre JJ cord-005453-4057qib7 13280 8 - - JJ cord-005453-4057qib7 13280 9 pubertal pubertal JJ cord-005453-4057qib7 13280 10 at at IN cord-005453-4057qib7 13280 11 HSCT HSCT NNP cord-005453-4057qib7 13280 12 ( ( -LRB- cord-005453-4057qib7 13280 13 f= f= NN cord-005453-4057qib7 13280 14 27;m=62 27;m=62 CD cord-005453-4057qib7 13280 15 ) ) -RRB- cord-005453-4057qib7 13280 16 and and CC cord-005453-4057qib7 13280 17 48/137(35 48/137(35 CD cord-005453-4057qib7 13280 18 % % NN cord-005453-4057qib7 13280 19 ) ) -RRB- cord-005453-4057qib7 13281 1 were be VBD cord-005453-4057qib7 13281 2 post post JJ cord-005453-4057qib7 13281 3 pubertal pubertal JJ cord-005453-4057qib7 13281 4 ( ( -LRB- cord-005453-4057qib7 13281 5 f=21;m=27 f=21;m=27 NNP cord-005453-4057qib7 13281 6 ) ) -RRB- cord-005453-4057qib7 13281 7 . . . cord-005453-4057qib7 13282 1 118/ 118/ LS cord-005453-4057qib7 13282 2 137 137 CD cord-005453-4057qib7 13282 3 ( ( -LRB- cord-005453-4057qib7 13282 4 86 86 CD cord-005453-4057qib7 13282 5 % % NN cord-005453-4057qib7 13282 6 ) ) -RRB- cord-005453-4057qib7 13283 1 patients patient NNS cord-005453-4057qib7 13283 2 received receive VBD cord-005453-4057qib7 13283 3 Bu Bu NNP cord-005453-4057qib7 13283 4 ( ( -LRB- cord-005453-4057qib7 13283 5 f=38;m=80),77/118 f=38;m=80),77/118 JJ cord-005453-4057qib7 13283 6 ( ( -LRB- cord-005453-4057qib7 13283 7 65 65 CD cord-005453-4057qib7 13283 8 % % NN cord-005453-4057qib7 13283 9 ) ) -RRB- cord-005453-4057qib7 13283 10 were be VBD cord-005453-4057qib7 13283 11 pre pre JJ cord-005453-4057qib7 13283 12 - - JJ cord-005453-4057qib7 13283 13 pubertal pubertal JJ cord-005453-4057qib7 13283 14 . . . cord-005453-4057qib7 13284 1 19/137 19/137 CD cord-005453-4057qib7 13285 1 ( ( -LRB- cord-005453-4057qib7 13285 2 14%)(f=10;m=9 14%)(f=10;m=9 NNP cord-005453-4057qib7 13285 3 ) ) -RRB- cord-005453-4057qib7 13285 4 received receive VBD cord-005453-4057qib7 13285 5 Treo,12/19 treo,12/19 NN cord-005453-4057qib7 13286 1 ( ( -LRB- cord-005453-4057qib7 13286 2 64 64 CD cord-005453-4057qib7 13286 3 % % NN cord-005453-4057qib7 13286 4 ) ) -RRB- cord-005453-4057qib7 13286 5 were be VBD cord-005453-4057qib7 13286 6 pre pre JJ cord-005453-4057qib7 13286 7 - - JJ cord-005453-4057qib7 13286 8 pubertal pubertal JJ cord-005453-4057qib7 13286 9 ( ( -LRB- cord-005453-4057qib7 13286 10 Figure figure NN cord-005453-4057qib7 13286 11 1 1 CD cord-005453-4057qib7 13286 12 ) ) -RRB- cord-005453-4057qib7 13286 13 . . . cord-005453-4057qib7 13287 1 Females female NNS cord-005453-4057qib7 13287 2 who who WP cord-005453-4057qib7 13287 3 received receive VBD cord-005453-4057qib7 13287 4 Treo Treo NNP cord-005453-4057qib7 13287 5 in in IN cord-005453-4057qib7 13287 6 pre pre JJ cord-005453-4057qib7 13287 7 - - JJ cord-005453-4057qib7 13287 8 pubertal pubertal JJ cord-005453-4057qib7 13287 9 stage stage NN cord-005453-4057qib7 13287 10 ( ( -LRB- cord-005453-4057qib7 13287 11 n=6/6 n=6/6 NNP cord-005453-4057qib7 13287 12 ) ) -RRB- cord-005453-4057qib7 13287 13 reached reach VBN cord-005453-4057qib7 13287 14 more more RBR cord-005453-4057qib7 13287 15 often often RB cord-005453-4057qib7 13287 16 spontaneous spontaneous JJ cord-005453-4057qib7 13287 17 puberty puberty NN cord-005453-4057qib7 13287 18 ( ( -LRB- cord-005453-4057qib7 13287 19 100 100 CD cord-005453-4057qib7 13287 20 % % NN cord-005453-4057qib7 13287 21 vs vs IN cord-005453-4057qib7 13287 22 38 38 CD cord-005453-4057qib7 13287 23 % % NN cord-005453-4057qib7 13287 24 ; ; , cord-005453-4057qib7 13287 25 p=0.016 p=0.016 JJS cord-005453-4057qib7 13287 26 ) ) -RRB- cord-005453-4057qib7 13287 27 compared compare VBN cord-005453-4057qib7 13287 28 to to IN cord-005453-4057qib7 13287 29 pre pre JJ cord-005453-4057qib7 13287 30 - - JJ cord-005453-4057qib7 13287 31 pubertal pubertal JJ cord-005453-4057qib7 13287 32 Bu Bu NNP cord-005453-4057qib7 13287 33 group group NN cord-005453-4057qib7 13287 34 ( ( -LRB- cord-005453-4057qib7 13287 35 n=8/21 n=8/21 NNP cord-005453-4057qib7 13287 36 ) ) -RRB- cord-005453-4057qib7 13288 1 and and CC cord-005453-4057qib7 13288 2 occurrence occurrence NN cord-005453-4057qib7 13288 3 of of IN cord-005453-4057qib7 13288 4 menarche menarche NN cord-005453-4057qib7 13288 5 was be VBD cord-005453-4057qib7 13288 6 higher high JJR cord-005453-4057qib7 13288 7 in in IN cord-005453-4057qib7 13288 8 Treo Treo NNP cord-005453-4057qib7 13288 9 group group NN cord-005453-4057qib7 13288 10 ( ( -LRB- cord-005453-4057qib7 13288 11 p p NN cord-005453-4057qib7 13288 12 < < XX cord-005453-4057qib7 13288 13 .01 .01 NFP cord-005453-4057qib7 13288 14 ) ) -RRB- cord-005453-4057qib7 13289 1 Hormonal hormonal JJ cord-005453-4057qib7 13289 2 replacement replacement NN cord-005453-4057qib7 13289 3 therapy therapy NN cord-005453-4057qib7 13289 4 was be VBD cord-005453-4057qib7 13289 5 given give VBN cord-005453-4057qib7 13289 6 in in IN cord-005453-4057qib7 13289 7 13/27 13/27 CD cord-005453-4057qib7 13289 8 ( ( -LRB- cord-005453-4057qib7 13289 9 48 48 CD cord-005453-4057qib7 13289 10 % % NN cord-005453-4057qib7 13289 11 ) ) -RRB- cord-005453-4057qib7 13289 12 females female NNS cord-005453-4057qib7 13289 13 transplanted transplant VBN cord-005453-4057qib7 13289 14 in in IN cord-005453-4057qib7 13289 15 pre pre JJ cord-005453-4057qib7 13289 16 - - JJ cord-005453-4057qib7 13289 17 pubertal pubertal JJ cord-005453-4057qib7 13289 18 stage stage NN cord-005453-4057qib7 13289 19 and and CC cord-005453-4057qib7 13289 20 in in IN cord-005453-4057qib7 13289 21 15/21 15/21 CD cord-005453-4057qib7 13289 22 ( ( -LRB- cord-005453-4057qib7 13289 23 71 71 CD cord-005453-4057qib7 13289 24 % % NN cord-005453-4057qib7 13289 25 ) ) -RRB- cord-005453-4057qib7 13289 26 of of IN cord-005453-4057qib7 13289 27 those those DT cord-005453-4057qib7 13289 28 transplanted transplant VBN cord-005453-4057qib7 13289 29 in in IN cord-005453-4057qib7 13289 30 post post JJ cord-005453-4057qib7 13289 31 - - JJ cord-005453-4057qib7 13289 32 pubertal pubertal JJ cord-005453-4057qib7 13289 33 stage stage NN cord-005453-4057qib7 13289 34 . . . cord-005453-4057qib7 13290 1 77/89 77/89 CD cord-005453-4057qib7 13290 2 ( ( -LRB- cord-005453-4057qib7 13290 3 86 86 CD cord-005453-4057qib7 13290 4 % % NN cord-005453-4057qib7 13290 5 ) ) -RRB- cord-005453-4057qib7 13290 6 males male NNS cord-005453-4057qib7 13290 7 were be VBD cord-005453-4057qib7 13290 8 pubertal pubertal JJ cord-005453-4057qib7 13290 9 at at IN cord-005453-4057qib7 13290 10 last last JJ cord-005453-4057qib7 13290 11 follow follow NN cord-005453-4057qib7 13290 12 - - HYPH cord-005453-4057qib7 13290 13 up up NN cord-005453-4057qib7 13290 14 and and CC cord-005453-4057qib7 13290 15 8 8 CD cord-005453-4057qib7 13290 16 of of IN cord-005453-4057qib7 13290 17 them -PRON- PRP cord-005453-4057qib7 13290 18 ( ( -LRB- cord-005453-4057qib7 13290 19 10 10 CD cord-005453-4057qib7 13290 20 % % NN cord-005453-4057qib7 13290 21 ) ) -RRB- cord-005453-4057qib7 13290 22 performed perform VBN cord-005453-4057qib7 13290 23 sperm sperm NN cord-005453-4057qib7 13290 24 analysis analysis NN cord-005453-4057qib7 13290 25 ( ( -LRB- cord-005453-4057qib7 13290 26 5 5 CD cord-005453-4057qib7 13290 27 oligo oligo NNP cord-005453-4057qib7 13290 28 - - HYPH cord-005453-4057qib7 13290 29 azoospermic,3 azoospermic,3 NNP cord-005453-4057qib7 13290 30 unknown unknown NN cord-005453-4057qib7 13290 31 ) ) -RRB- cord-005453-4057qib7 13290 32 . . . cord-005453-4057qib7 13291 1 Three three CD cord-005453-4057qib7 13291 2 pregnancies pregnancy NNS cord-005453-4057qib7 13291 3 were be VBD cord-005453-4057qib7 13291 4 reported report VBN cord-005453-4057qib7 13291 5 in in IN cord-005453-4057qib7 13291 6 the the DT cord-005453-4057qib7 13291 7 population population NN cord-005453-4057qib7 13291 8 group group NN cord-005453-4057qib7 13291 9 , , , cord-005453-4057qib7 13291 10 all all DT cord-005453-4057qib7 13291 11 received receive VBN cord-005453-4057qib7 13291 12 Bu Bu NNP cord-005453-4057qib7 13291 13 . . . cord-005453-4057qib7 13292 1 Regarding regard VBG cord-005453-4057qib7 13292 2 the the DT cord-005453-4057qib7 13292 3 evaluation evaluation NN cord-005453-4057qib7 13292 4 of of IN cord-005453-4057qib7 13292 5 hormonal hormonal JJ cord-005453-4057qib7 13292 6 levels level NNS cord-005453-4057qib7 13292 7 in in IN cord-005453-4057qib7 13292 8 pubertal pubertal JJ cord-005453-4057qib7 13292 9 patients patient NNS cord-005453-4057qib7 13292 10 at at IN cord-005453-4057qib7 13292 11 time time NN cord-005453-4057qib7 13292 12 of of IN cord-005453-4057qib7 13292 13 hormonal hormonal JJ cord-005453-4057qib7 13292 14 dosage dosage NN cord-005453-4057qib7 13292 15 ( ( -LRB- cord-005453-4057qib7 13292 16 median median NN cord-005453-4057qib7 13292 17 19.54 19.54 CD cord-005453-4057qib7 13292 18 yrs yr NNS cord-005453-4057qib7 13292 19 ) ) -RRB- cord-005453-4057qib7 13292 20 ( ( -LRB- cord-005453-4057qib7 13292 21 66 66 CD cord-005453-4057qib7 13292 22 Bu Bu NNP cord-005453-4057qib7 13292 23 and and CC cord-005453-4057qib7 13292 24 15 15 CD cord-005453-4057qib7 13292 25 Treo Treo NNP cord-005453-4057qib7 13292 26 ) ) -RRB- cord-005453-4057qib7 13292 27 , , , cord-005453-4057qib7 13292 28 males male NNS cord-005453-4057qib7 13292 29 treated treat VBN cord-005453-4057qib7 13292 30 with with IN cord-005453-4057qib7 13292 31 Treo Treo NNP cord-005453-4057qib7 13292 32 had have VBD cord-005453-4057qib7 13292 33 significant significant JJ cord-005453-4057qib7 13292 34 lower low JJR cord-005453-4057qib7 13292 35 LH LH NNP cord-005453-4057qib7 13292 36 levels level NNS cord-005453-4057qib7 13292 37 ( ( -LRB- cord-005453-4057qib7 13292 38 p p NN cord-005453-4057qib7 13292 39 = = SYM cord-005453-4057qib7 13292 40 0.045 0.045 CD cord-005453-4057qib7 13292 41 ) ) -RRB- cord-005453-4057qib7 13292 42 compared compare VBN cord-005453-4057qib7 13292 43 to to IN cord-005453-4057qib7 13292 44 Bu Bu NNP cord-005453-4057qib7 13292 45 group group NN cord-005453-4057qib7 13292 46 . . . cord-005453-4057qib7 13293 1 Females female NNS cord-005453-4057qib7 13293 2 treated treat VBN cord-005453-4057qib7 13293 3 with with IN cord-005453-4057qib7 13293 4 Treo Treo NNP cord-005453-4057qib7 13293 5 had have VBD cord-005453-4057qib7 13293 6 significant significant JJ cord-005453-4057qib7 13293 7 lower low JJR cord-005453-4057qib7 13293 8 levels level NNS cord-005453-4057qib7 13293 9 of of IN cord-005453-4057qib7 13293 10 LH lh NN cord-005453-4057qib7 13293 11 and and CC cord-005453-4057qib7 13293 12 FSH FSH NNP cord-005453-4057qib7 13293 13 ( ( -LRB- cord-005453-4057qib7 13293 14 p= p= NNP cord-005453-4057qib7 13293 15 0.02 0.02 CD cord-005453-4057qib7 13293 16 and and CC cord-005453-4057qib7 13293 17 p= p= JJ cord-005453-4057qib7 13293 18 0.0035 0.0035 CD cord-005453-4057qib7 13293 19 respectively respectively RB cord-005453-4057qib7 13293 20 ) ) -RRB- cord-005453-4057qib7 13293 21 . . . cord-005453-4057qib7 13294 1 Conclusions conclusion NNS cord-005453-4057qib7 13294 2 : : : cord-005453-4057qib7 13295 1 Gonadal gonadal NN cord-005453-4057qib7 13295 2 damage damage NN cord-005453-4057qib7 13295 3 related relate VBN cord-005453-4057qib7 13295 4 to to IN cord-005453-4057qib7 13295 5 Treo Treo NNP cord-005453-4057qib7 13295 6 was be VBD cord-005453-4057qib7 13295 7 significantly significantly RB cord-005453-4057qib7 13295 8 lower low JJR cord-005453-4057qib7 13295 9 compared compare VBN cord-005453-4057qib7 13295 10 to to IN cord-005453-4057qib7 13295 11 Bu Bu NNP cord-005453-4057qib7 13295 12 . . . cord-005453-4057qib7 13296 1 We -PRON- PRP cord-005453-4057qib7 13296 2 observed observe VBD cord-005453-4057qib7 13296 3 that that DT cord-005453-4057qib7 13296 4 : : : cord-005453-4057qib7 13296 5 females female NNS cord-005453-4057qib7 13296 6 transplanted transplant VBN cord-005453-4057qib7 13296 7 during during IN cord-005453-4057qib7 13296 8 pre pre JJ cord-005453-4057qib7 13296 9 - - JJ cord-005453-4057qib7 13296 10 pubertal pubertal JJ cord-005453-4057qib7 13296 11 period period NN cord-005453-4057qib7 13296 12 had have VBD cord-005453-4057qib7 13296 13 spontaneous spontaneous JJ cord-005453-4057qib7 13296 14 puberty puberty NN cord-005453-4057qib7 13296 15 more more RBR cord-005453-4057qib7 13296 16 frequently frequently RB cord-005453-4057qib7 13296 17 after after IN cord-005453-4057qib7 13296 18 Treo Treo NNP cord-005453-4057qib7 13296 19 compared compare VBN cord-005453-4057qib7 13296 20 to to IN cord-005453-4057qib7 13296 21 Bu Bu NNP cord-005453-4057qib7 13296 22 and and CC cord-005453-4057qib7 13296 23 that that IN cord-005453-4057qib7 13296 24 hypogonadism hypogonadism NNP cord-005453-4057qib7 13296 25 hypergonadotropic hypergonadotropic NNP cord-005453-4057qib7 13296 26 was be VBD cord-005453-4057qib7 13296 27 more more RBR cord-005453-4057qib7 13296 28 frequent frequent JJ cord-005453-4057qib7 13296 29 after after IN cord-005453-4057qib7 13296 30 Bu Bu NNP cord-005453-4057qib7 13296 31 than than IN cord-005453-4057qib7 13296 32 Treo Treo NNP cord-005453-4057qib7 13296 33 . . . cord-005453-4057qib7 13297 1 These these DT cord-005453-4057qib7 13297 2 results result NNS cord-005453-4057qib7 13297 3 must must MD cord-005453-4057qib7 13297 4 be be VB cord-005453-4057qib7 13297 5 further further RB cord-005453-4057qib7 13297 6 confirmed confirm VBN cord-005453-4057qib7 13297 7 on on IN cord-005453-4057qib7 13297 8 a a DT cord-005453-4057qib7 13297 9 larger large JJR cord-005453-4057qib7 13297 10 population population NN cord-005453-4057qib7 13297 11 . . . cord-005453-4057qib7 13298 1 Background background NN cord-005453-4057qib7 13298 2 : : : cord-005453-4057qib7 13299 1 Viral viral JJ cord-005453-4057qib7 13299 2 infections infection NNS cord-005453-4057qib7 13299 3 significantly significantly RB cord-005453-4057qib7 13299 4 contribute contribute VBP cord-005453-4057qib7 13299 5 to to IN cord-005453-4057qib7 13299 6 both both CC cord-005453-4057qib7 13299 7 morbidity morbidity NN cord-005453-4057qib7 13299 8 and and CC cord-005453-4057qib7 13299 9 mortality mortality NN cord-005453-4057qib7 13299 10 in in IN cord-005453-4057qib7 13299 11 patients patient NNS cord-005453-4057qib7 13299 12 undergoing undergo VBG cord-005453-4057qib7 13299 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 13299 14 stem stem NN cord-005453-4057qib7 13299 15 cell cell NN cord-005453-4057qib7 13299 16 transplantation transplantation NN cord-005453-4057qib7 13299 17 . . . cord-005453-4057qib7 13300 1 Traditional traditional JJ cord-005453-4057qib7 13300 2 antiviral antiviral JJ cord-005453-4057qib7 13300 3 therapy therapy NN cord-005453-4057qib7 13300 4 is be VBZ cord-005453-4057qib7 13300 5 associated associate VBN cord-005453-4057qib7 13300 6 with with IN cord-005453-4057qib7 13300 7 lack lack NN cord-005453-4057qib7 13300 8 of of IN cord-005453-4057qib7 13300 9 efficacy efficacy NN cord-005453-4057qib7 13300 10 , , , cord-005453-4057qib7 13300 11 potential potential JJ cord-005453-4057qib7 13300 12 toxicity toxicity NN cord-005453-4057qib7 13300 13 , , , cord-005453-4057qib7 13300 14 prolonged prolong VBN cord-005453-4057qib7 13300 15 hospitalization hospitalization NN cord-005453-4057qib7 13300 16 and and CC cord-005453-4057qib7 13300 17 increased increase VBN cord-005453-4057qib7 13300 18 patient patient NN cord-005453-4057qib7 13300 19 costs cost NNS cord-005453-4057qib7 13300 20 . . . cord-005453-4057qib7 13301 1 Viral viral JJ cord-005453-4057qib7 13301 2 specific specific JJ cord-005453-4057qib7 13301 3 T t NN cord-005453-4057qib7 13301 4 cells cell NNS cord-005453-4057qib7 13301 5 can can MD cord-005453-4057qib7 13301 6 be be VB cord-005453-4057qib7 13301 7 manufactured manufacture VBN cord-005453-4057qib7 13301 8 from from IN cord-005453-4057qib7 13301 9 donor donor NN cord-005453-4057qib7 13301 10 blood blood NN cord-005453-4057qib7 13301 11 to to TO cord-005453-4057qib7 13301 12 treat treat VB cord-005453-4057qib7 13301 13 viral viral JJ cord-005453-4057qib7 13301 14 infections infection NNS cord-005453-4057qib7 13301 15 post post NN cord-005453-4057qib7 13301 16 - - NN cord-005453-4057qib7 13301 17 transplant transplant NN cord-005453-4057qib7 13301 18 , , , cord-005453-4057qib7 13301 19 and and CC cord-005453-4057qib7 13301 20 are be VBP cord-005453-4057qib7 13301 21 associated associate VBN cord-005453-4057qib7 13301 22 with with IN cord-005453-4057qib7 13301 23 increased increase VBN cord-005453-4057qib7 13301 24 clinical clinical JJ cord-005453-4057qib7 13301 25 efficacy efficacy NN cord-005453-4057qib7 13301 26 and and CC cord-005453-4057qib7 13301 27 low low JJ cord-005453-4057qib7 13301 28 toxicity toxicity NN cord-005453-4057qib7 13301 29 . . . cord-005453-4057qib7 13302 1 We -PRON- PRP cord-005453-4057qib7 13302 2 postulated postulate VBD cord-005453-4057qib7 13302 3 that that IN cord-005453-4057qib7 13302 4 direct direct JJ cord-005453-4057qib7 13302 5 costs cost NNS cord-005453-4057qib7 13302 6 of of IN cord-005453-4057qib7 13302 7 VST VST NNP cord-005453-4057qib7 13302 8 therapy therapy NN cord-005453-4057qib7 13302 9 are be VBP cord-005453-4057qib7 13302 10 lower low JJR cord-005453-4057qib7 13302 11 compared compare VBN cord-005453-4057qib7 13302 12 to to IN cord-005453-4057qib7 13302 13 traditional traditional JJ cord-005453-4057qib7 13302 14 anti anti JJ cord-005453-4057qib7 13302 15 - - JJ cord-005453-4057qib7 13302 16 viral viral JJ cord-005453-4057qib7 13302 17 medications medication NNS cord-005453-4057qib7 13302 18 Methods method NNS cord-005453-4057qib7 13302 19 : : : cord-005453-4057qib7 13302 20 VSTs vst NNS cord-005453-4057qib7 13302 21 were be VBD cord-005453-4057qib7 13302 22 manufactured manufacture VBN cord-005453-4057qib7 13302 23 according accord VBG cord-005453-4057qib7 13302 24 to to IN cord-005453-4057qib7 13302 25 local local JJ cord-005453-4057qib7 13302 26 protocols protocol NNS cord-005453-4057qib7 13302 27 and and CC cord-005453-4057qib7 13302 28 FDA FDA NNP cord-005453-4057qib7 13302 29 requirements requirement NNS cord-005453-4057qib7 13302 30 . . . cord-005453-4057qib7 13303 1 Total total JJ cord-005453-4057qib7 13303 2 drug drug NN cord-005453-4057qib7 13303 3 cost cost NN cord-005453-4057qib7 13303 4 ( ( -LRB- cord-005453-4057qib7 13303 5 as as IN cord-005453-4057qib7 13303 6 per per IN cord-005453-4057qib7 13303 7 institutional institutional JJ cord-005453-4057qib7 13303 8 charges charge NNS cord-005453-4057qib7 13303 9 per per IN cord-005453-4057qib7 13303 10 drug drug NN cord-005453-4057qib7 13303 11 ) ) -RRB- cord-005453-4057qib7 13303 12 was be VBD cord-005453-4057qib7 13303 13 calculated calculate VBN cord-005453-4057qib7 13303 14 for for IN cord-005453-4057qib7 13303 15 patients patient NNS cord-005453-4057qib7 13303 16 who who WP cord-005453-4057qib7 13303 17 required require VBD cord-005453-4057qib7 13303 18 treatment treatment NN cord-005453-4057qib7 13303 19 for for IN cord-005453-4057qib7 13303 20 viral viral JJ cord-005453-4057qib7 13303 21 infections infection NNS cord-005453-4057qib7 13303 22 post post VBP cord-005453-4057qib7 13303 23 - - JJ cord-005453-4057qib7 13303 24 HSCT HSCT NNP cord-005453-4057qib7 13303 25 . . . cord-005453-4057qib7 13304 1 Manufacturing manufacturing NN cord-005453-4057qib7 13304 2 costs cost NNS cord-005453-4057qib7 13304 3 of of IN cord-005453-4057qib7 13304 4 VSTs vst NNS cord-005453-4057qib7 13304 5 are be VBP cord-005453-4057qib7 13304 6 fixed fix VBN cord-005453-4057qib7 13304 7 per per IN cord-005453-4057qib7 13304 8 FDA FDA NNP cord-005453-4057qib7 13304 9 requirements requirement NNS cord-005453-4057qib7 13304 10 . . . cord-005453-4057qib7 13305 1 Patients patient NNS cord-005453-4057qib7 13305 2 who who WP cord-005453-4057qib7 13305 3 were be VBD cord-005453-4057qib7 13305 4 treated treat VBN cord-005453-4057qib7 13305 5 with with IN cord-005453-4057qib7 13305 6 investigational investigational JJ cord-005453-4057qib7 13305 7 antiviral antiviral JJ cord-005453-4057qib7 13305 8 medications medication NNS cord-005453-4057qib7 13305 9 ( ( -LRB- cord-005453-4057qib7 13305 10 including include VBG cord-005453-4057qib7 13305 11 brincidofovir brincidofovir NNS cord-005453-4057qib7 13305 12 ) ) -RRB- cord-005453-4057qib7 13305 13 were be VBD cord-005453-4057qib7 13305 14 excluded exclude VBN cord-005453-4057qib7 13305 15 from from IN cord-005453-4057qib7 13305 16 analysis analysis NN cord-005453-4057qib7 13305 17 . . . cord-005453-4057qib7 13306 1 Patients patient NNS cord-005453-4057qib7 13306 2 treated treat VBN cord-005453-4057qib7 13306 3 with with IN cord-005453-4057qib7 13306 4 VSTs vst NNS cord-005453-4057qib7 13306 5 + + CC cord-005453-4057qib7 13306 6 /anti /anti JJ cord-005453-4057qib7 13306 7 - - HYPH cord-005453-4057qib7 13306 8 viral viral JJ cord-005453-4057qib7 13306 9 medications medication NNS cord-005453-4057qib7 13306 10 over over IN cord-005453-4057qib7 13306 11 a a DT cord-005453-4057qib7 13306 12 2 2 CD cord-005453-4057qib7 13306 13 year year NN cord-005453-4057qib7 13306 14 period period NN cord-005453-4057qib7 13306 15 were be VBD cord-005453-4057qib7 13306 16 compared compare VBN cord-005453-4057qib7 13306 17 to to IN cord-005453-4057qib7 13306 18 patients patient NNS cord-005453-4057qib7 13306 19 treated treat VBN cord-005453-4057qib7 13306 20 only only RB cord-005453-4057qib7 13306 21 using use VBG cord-005453-4057qib7 13306 22 traditional traditional JJ cord-005453-4057qib7 13306 23 anti anti JJ cord-005453-4057qib7 13306 24 - - JJ cord-005453-4057qib7 13306 25 viral viral JJ cord-005453-4057qib7 13306 26 medications medication NNS cord-005453-4057qib7 13306 27 , , , cord-005453-4057qib7 13306 28 including include VBG cord-005453-4057qib7 13306 29 cidofovir cidofovir NNS cord-005453-4057qib7 13306 30 , , , cord-005453-4057qib7 13306 31 ganciclovir ganciclovir NNP cord-005453-4057qib7 13306 32 , , , cord-005453-4057qib7 13306 33 valganciclovir valganciclovir NNP cord-005453-4057qib7 13306 34 , , , cord-005453-4057qib7 13306 35 foscarnet foscarnet NN cord-005453-4057qib7 13306 36 and and CC cord-005453-4057qib7 13306 37 rituximab rituximab NN cord-005453-4057qib7 13306 38 . . . cord-005453-4057qib7 13307 1 Results result NNS cord-005453-4057qib7 13307 2 : : : cord-005453-4057qib7 13308 1 Demographics demographic NNS cord-005453-4057qib7 13308 2 are be VBP cord-005453-4057qib7 13308 3 shown show VBN cord-005453-4057qib7 13308 4 in in IN cord-005453-4057qib7 13308 5 Table Table NNP cord-005453-4057qib7 13308 6 1 1 CD cord-005453-4057qib7 13308 7 . . . cord-005453-4057qib7 13309 1 There there EX cord-005453-4057qib7 13309 2 were be VBD cord-005453-4057qib7 13309 3 no no DT cord-005453-4057qib7 13309 4 major major JJ cord-005453-4057qib7 13309 5 differences difference NNS cord-005453-4057qib7 13309 6 between between IN cord-005453-4057qib7 13309 7 the the DT cord-005453-4057qib7 13309 8 two two CD cord-005453-4057qib7 13309 9 groups group NNS cord-005453-4057qib7 13309 10 treated treat VBN cord-005453-4057qib7 13309 11 . . . cord-005453-4057qib7 13310 1 The the DT cord-005453-4057qib7 13310 2 number number NN cord-005453-4057qib7 13310 3 of of IN cord-005453-4057qib7 13310 4 anti anti JJ cord-005453-4057qib7 13310 5 - - JJ cord-005453-4057qib7 13310 6 viral viral JJ cord-005453-4057qib7 13310 7 medications medication NNS cord-005453-4057qib7 13310 8 used use VBN cord-005453-4057qib7 13310 9 in in IN cord-005453-4057qib7 13310 10 the the DT cord-005453-4057qib7 13310 11 VST VST NNP cord-005453-4057qib7 13310 12 group group NN cord-005453-4057qib7 13310 13 was be VBD cord-005453-4057qib7 13310 14 lower low JJR cord-005453-4057qib7 13310 15 compared compare VBN cord-005453-4057qib7 13310 16 to to IN cord-005453-4057qib7 13310 17 the the DT cord-005453-4057qib7 13310 18 anti anti JJ cord-005453-4057qib7 13310 19 - - JJ cord-005453-4057qib7 13310 20 viral viral JJ cord-005453-4057qib7 13310 21 treatment treatment NN cord-005453-4057qib7 13310 22 group group NN cord-005453-4057qib7 13310 23 . . . cord-005453-4057qib7 13311 1 Median median JJ cord-005453-4057qib7 13311 2 cost cost NN cord-005453-4057qib7 13311 3 of of IN cord-005453-4057qib7 13311 4 VST VST NNP cord-005453-4057qib7 13311 5 treatment treatment NN cord-005453-4057qib7 13311 6 was be VBD cord-005453-4057qib7 13311 7 significantly significantly RB cord-005453-4057qib7 13311 8 lower low JJR cord-005453-4057qib7 13311 9 compared compare VBN cord-005453-4057qib7 13311 10 to to IN cord-005453-4057qib7 13311 11 those those DT cord-005453-4057qib7 13311 12 threated threate VBN cord-005453-4057qib7 13311 13 with with IN cord-005453-4057qib7 13311 14 traditional traditional JJ cord-005453-4057qib7 13311 15 anti anti JJ cord-005453-4057qib7 13311 16 - - JJ cord-005453-4057qib7 13311 17 viral viral JJ cord-005453-4057qib7 13311 18 therapy therapy NN cord-005453-4057qib7 13311 19 ( ( -LRB- cord-005453-4057qib7 13311 20 $ $ $ cord-005453-4057qib7 13311 21 12,757 12,757 CD cord-005453-4057qib7 13311 22 vs vs IN cord-005453-4057qib7 13311 23 $ $ $ cord-005453-4057qib7 13311 24 16,392 16,392 CD cord-005453-4057qib7 13311 25 , , , cord-005453-4057qib7 13311 26 p p NN cord-005453-4057qib7 13311 27 - - : cord-005453-4057qib7 13311 28 value=0.03 value=0.03 NNP cord-005453-4057qib7 13311 29 ) ) -RRB- cord-005453-4057qib7 13311 30 . . . cord-005453-4057qib7 13312 1 Conclusions conclusion NNS cord-005453-4057qib7 13312 2 : : : cord-005453-4057qib7 13313 1 Treatment treatment NN cord-005453-4057qib7 13313 2 with with IN cord-005453-4057qib7 13313 3 VSTs vst NNS cord-005453-4057qib7 13313 4 post post VBP cord-005453-4057qib7 13313 5 - - JJ cord-005453-4057qib7 13313 6 HSCT HSCT NNP cord-005453-4057qib7 13313 7 for for IN cord-005453-4057qib7 13313 8 viral viral JJ cord-005453-4057qib7 13313 9 infections infection NNS cord-005453-4057qib7 13313 10 was be VBD cord-005453-4057qib7 13313 11 lower low JJR cord-005453-4057qib7 13313 12 in in IN cord-005453-4057qib7 13313 13 cost cost NN cord-005453-4057qib7 13313 14 compared compare VBN cord-005453-4057qib7 13313 15 to to IN cord-005453-4057qib7 13313 16 anti anti JJ cord-005453-4057qib7 13313 17 - - JJ cord-005453-4057qib7 13313 18 viral viral JJ cord-005453-4057qib7 13313 19 medical medical JJ cord-005453-4057qib7 13313 20 therapy therapy NN cord-005453-4057qib7 13313 21 . . . cord-005453-4057qib7 13314 1 It -PRON- PRP cord-005453-4057qib7 13314 2 is be VBZ cord-005453-4057qib7 13314 3 likely likely JJ cord-005453-4057qib7 13314 4 that that IN cord-005453-4057qib7 13314 5 overall overall JJ cord-005453-4057qib7 13314 6 costs cost NNS cord-005453-4057qib7 13314 7 are be VBP cord-005453-4057qib7 13314 8 further further RB cord-005453-4057qib7 13314 9 reduced reduce VBN cord-005453-4057qib7 13314 10 with with IN cord-005453-4057qib7 13314 11 VSTs vst NNS cord-005453-4057qib7 13314 12 due due JJ cord-005453-4057qib7 13314 13 to to IN cord-005453-4057qib7 13314 14 reduced reduce VBN cord-005453-4057qib7 13314 15 inpatient inpatient JJ cord-005453-4057qib7 13314 16 hospital hospital NN cord-005453-4057qib7 13314 17 time time NN cord-005453-4057qib7 13314 18 , , , cord-005453-4057qib7 13314 19 less less JJR cord-005453-4057qib7 13314 20 monitoring monitoring NN cord-005453-4057qib7 13314 21 of of IN cord-005453-4057qib7 13314 22 labs lab NNS cord-005453-4057qib7 13314 23 associated associate VBN cord-005453-4057qib7 13314 24 with with IN cord-005453-4057qib7 13314 25 anti anti JJ cord-005453-4057qib7 13314 26 - - JJ cord-005453-4057qib7 13314 27 viral viral JJ cord-005453-4057qib7 13314 28 medication medication NN cord-005453-4057qib7 13314 29 side side NN cord-005453-4057qib7 13314 30 - - HYPH cord-005453-4057qib7 13314 31 effects effect NNS cord-005453-4057qib7 13314 32 and and CC cord-005453-4057qib7 13314 33 reduced reduce VBN cord-005453-4057qib7 13314 34 ancillary ancillary JJ cord-005453-4057qib7 13314 35 costs cost NNS cord-005453-4057qib7 13314 36 including include VBG cord-005453-4057qib7 13314 37 nursing nursing NN cord-005453-4057qib7 13314 38 and and CC cord-005453-4057qib7 13314 39 pharmacy pharmacy NN cord-005453-4057qib7 13314 40 . . . cord-005453-4057qib7 13315 1 More More JJR cord-005453-4057qib7 13315 2 studies study NNS cord-005453-4057qib7 13315 3 are be VBP cord-005453-4057qib7 13315 4 needed need VBN cord-005453-4057qib7 13315 5 to to TO cord-005453-4057qib7 13315 6 examine examine VB cord-005453-4057qib7 13315 7 these these DT cord-005453-4057qib7 13315 8 indirect indirect JJ cord-005453-4057qib7 13315 9 costs cost NNS cord-005453-4057qib7 13315 10 further further RB cord-005453-4057qib7 13315 11 . . . cord-005453-4057qib7 13316 1 Background background NN cord-005453-4057qib7 13316 2 : : : cord-005453-4057qib7 13317 1 DOCK8 DOCK8 NNP cord-005453-4057qib7 13317 2 deficiency deficiency NN cord-005453-4057qib7 13317 3 is be VBZ cord-005453-4057qib7 13317 4 an an DT cord-005453-4057qib7 13317 5 autosomal autosomal JJ cord-005453-4057qib7 13317 6 recessive recessive JJ cord-005453-4057qib7 13317 7 primary primary JJ cord-005453-4057qib7 13317 8 immunodeficiency immunodeficiency NN cord-005453-4057qib7 13317 9 ( ( -LRB- cord-005453-4057qib7 13317 10 PID PID NNP cord-005453-4057qib7 13317 11 ) ) -RRB- cord-005453-4057qib7 13317 12 disease disease NN cord-005453-4057qib7 13317 13 caused cause VBN cord-005453-4057qib7 13317 14 by by IN cord-005453-4057qib7 13317 15 loss loss NN cord-005453-4057qib7 13317 16 - - HYPH cord-005453-4057qib7 13317 17 offunction offunction NN cord-005453-4057qib7 13317 18 mutations mutation NNS cord-005453-4057qib7 13317 19 in in IN cord-005453-4057qib7 13317 20 the the DT cord-005453-4057qib7 13317 21 DOCK8 dock8 NN cord-005453-4057qib7 13317 22 gene gene NN cord-005453-4057qib7 13317 23 ( ( -LRB- cord-005453-4057qib7 13317 24 1 1 CD cord-005453-4057qib7 13317 25 ) ) -RRB- cord-005453-4057qib7 13317 26 . . . cord-005453-4057qib7 13318 1 Patients patient NNS cord-005453-4057qib7 13318 2 with with IN cord-005453-4057qib7 13318 3 DOCK8 dock8 NN cord-005453-4057qib7 13318 4 deficiency deficiency NN cord-005453-4057qib7 13318 5 present present JJ cord-005453-4057qib7 13318 6 with with IN cord-005453-4057qib7 13318 7 multiple multiple JJ cord-005453-4057qib7 13318 8 abnormalities abnormality NNS cord-005453-4057qib7 13318 9 of of IN cord-005453-4057qib7 13318 10 the the DT cord-005453-4057qib7 13318 11 immune immune JJ cord-005453-4057qib7 13318 12 system system NN cord-005453-4057qib7 13318 13 , , , cord-005453-4057qib7 13318 14 including include VBG cord-005453-4057qib7 13318 15 defective defective JJ cord-005453-4057qib7 13318 16 T T NNP cord-005453-4057qib7 13318 17 cell cell NN cord-005453-4057qib7 13318 18 function function NN cord-005453-4057qib7 13318 19 and and CC cord-005453-4057qib7 13318 20 impaired impaired JJ cord-005453-4057qib7 13318 21 production production NN cord-005453-4057qib7 13318 22 of of IN cord-005453-4057qib7 13318 23 antigen antigen NN cord-005453-4057qib7 13318 24 - - HYPH cord-005453-4057qib7 13318 25 specific specific JJ cord-005453-4057qib7 13318 26 antibodies antibody NNS cord-005453-4057qib7 13318 27 . . . cord-005453-4057qib7 13319 1 These these DT cord-005453-4057qib7 13319 2 lead lead VBP cord-005453-4057qib7 13319 3 to to IN cord-005453-4057qib7 13319 4 persistent persistent JJ cord-005453-4057qib7 13319 5 viral viral JJ cord-005453-4057qib7 13319 6 infections infection NNS cord-005453-4057qib7 13319 7 of of IN cord-005453-4057qib7 13319 8 the the DT cord-005453-4057qib7 13319 9 skin skin NN cord-005453-4057qib7 13319 10 , , , cord-005453-4057qib7 13319 11 mucocutaneous mucocutaneous JJ cord-005453-4057qib7 13319 12 candidiasis candidiasis NN cord-005453-4057qib7 13319 13 , , , cord-005453-4057qib7 13319 14 recurrent recurrent JJ cord-005453-4057qib7 13319 15 sinopulmonary sinopulmonary JJ cord-005453-4057qib7 13319 16 infections infection NNS cord-005453-4057qib7 13319 17 , , , cord-005453-4057qib7 13319 18 atopic atopic JJ cord-005453-4057qib7 13319 19 dermatitis dermatitis NN cord-005453-4057qib7 13319 20 , , , cord-005453-4057qib7 13319 21 and and CC cord-005453-4057qib7 13319 22 other other JJ cord-005453-4057qib7 13319 23 allergic allergic JJ cord-005453-4057qib7 13319 24 disease disease NN cord-005453-4057qib7 13319 25 , , , cord-005453-4057qib7 13319 26 malignancies malignancy NNS cord-005453-4057qib7 13319 27 , , , cord-005453-4057qib7 13319 28 and and CC cord-005453-4057qib7 13319 29 sometimes sometimes RB cord-005453-4057qib7 13319 30 autoimmunity autoimmunity NN cord-005453-4057qib7 13319 31 ( ( -LRB- cord-005453-4057qib7 13319 32 2 2 CD cord-005453-4057qib7 13319 33 ) ) -RRB- cord-005453-4057qib7 13319 34 . . . cord-005453-4057qib7 13320 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 13320 2 stem stem NN cord-005453-4057qib7 13320 3 cell cell NN cord-005453-4057qib7 13320 4 transplantation transplantation NN cord-005453-4057qib7 13320 5 ( ( -LRB- cord-005453-4057qib7 13320 6 HSCT HSCT NNP cord-005453-4057qib7 13320 7 ) ) -RRB- cord-005453-4057qib7 13320 8 is be VBZ cord-005453-4057qib7 13320 9 currently currently RB cord-005453-4057qib7 13320 10 the the DT cord-005453-4057qib7 13320 11 only only JJ cord-005453-4057qib7 13320 12 curative curative JJ cord-005453-4057qib7 13320 13 treatment treatment NN cord-005453-4057qib7 13320 14 option option NN cord-005453-4057qib7 13320 15 available available JJ cord-005453-4057qib7 13320 16 ( ( -LRB- cord-005453-4057qib7 13320 17 3 3 CD cord-005453-4057qib7 13320 18 ) ) -RRB- cord-005453-4057qib7 13320 19 . . . cord-005453-4057qib7 13321 1 Methods method NNS cord-005453-4057qib7 13322 1 : : : cord-005453-4057qib7 13322 2 We -PRON- PRP cord-005453-4057qib7 13322 3 retrospectively retrospectively RB cord-005453-4057qib7 13322 4 evaluated evaluate VBD cord-005453-4057qib7 13322 5 our -PRON- PRP$ cord-005453-4057qib7 13322 6 patients patient NNS cord-005453-4057qib7 13322 7 who who WP cord-005453-4057qib7 13322 8 underwent undergo VBD cord-005453-4057qib7 13322 9 allogeneic allogeneic JJ cord-005453-4057qib7 13322 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 13322 11 stem stem NN cord-005453-4057qib7 13322 12 cell cell NN cord-005453-4057qib7 13322 13 transplantation transplantation NN cord-005453-4057qib7 13322 14 due due IN cord-005453-4057qib7 13322 15 to to IN cord-005453-4057qib7 13322 16 DOCK8 dock8 XX cord-005453-4057qib7 13322 17 deficiency deficiency NN cord-005453-4057qib7 13322 18 in in IN cord-005453-4057qib7 13322 19 Ege Ege NNP cord-005453-4057qib7 13322 20 University University NNP cord-005453-4057qib7 13322 21 Pediatric Pediatric NNP cord-005453-4057qib7 13322 22 Stem Stem NNP cord-005453-4057qib7 13322 23 Cell Cell NNP cord-005453-4057qib7 13322 24 Transplantation Transplantation NNP cord-005453-4057qib7 13322 25 Unit Unit NNP cord-005453-4057qib7 13322 26 between between IN cord-005453-4057qib7 13322 27 2013 2013 CD cord-005453-4057qib7 13322 28 and and CC cord-005453-4057qib7 13322 29 2018 2018 CD cord-005453-4057qib7 13322 30 . . . cord-005453-4057qib7 13323 1 Results result NNS cord-005453-4057qib7 13323 2 : : : cord-005453-4057qib7 13324 1 We -PRON- PRP cord-005453-4057qib7 13324 2 identified identify VBD cord-005453-4057qib7 13324 3 16 16 CD cord-005453-4057qib7 13324 4 patients patient NNS cord-005453-4057qib7 13324 5 transplanted transplant VBN cord-005453-4057qib7 13324 6 at at IN cord-005453-4057qib7 13324 7 a a DT cord-005453-4057qib7 13324 8 median median JJ cord-005453-4057qib7 13324 9 age age NN cord-005453-4057qib7 13324 10 of of IN cord-005453-4057qib7 13324 11 7.8 7.8 CD cord-005453-4057qib7 13324 12 years year NNS cord-005453-4057qib7 13324 13 ( ( -LRB- cord-005453-4057qib7 13324 14 range range NN cord-005453-4057qib7 13324 15 : : : cord-005453-4057qib7 13324 16 2 2 CD cord-005453-4057qib7 13324 17 - - SYM cord-005453-4057qib7 13324 18 15.5 15.5 CD cord-005453-4057qib7 13324 19 years year NNS cord-005453-4057qib7 13324 20 ) ) -RRB- cord-005453-4057qib7 13324 21 . . . cord-005453-4057qib7 13325 1 Of of IN cord-005453-4057qib7 13325 2 16 16 CD cord-005453-4057qib7 13325 3 patients patient NNS cord-005453-4057qib7 13325 4 ; ; : cord-005453-4057qib7 13325 5 4 4 CD cord-005453-4057qib7 13325 6 ( ( -LRB- cord-005453-4057qib7 13325 7 % % NN cord-005453-4057qib7 13325 8 25 25 CD cord-005453-4057qib7 13325 9 ) ) -RRB- cord-005453-4057qib7 13325 10 received receive VBD cord-005453-4057qib7 13325 11 HSCT HSCT NNP cord-005453-4057qib7 13325 12 from from IN cord-005453-4057qib7 13325 13 matched match VBN cord-005453-4057qib7 13325 14 sibling sibling NN cord-005453-4057qib7 13325 15 , , , cord-005453-4057qib7 13325 16 11 11 CD cord-005453-4057qib7 13325 17 ( ( -LRB- cord-005453-4057qib7 13325 18 % % NN cord-005453-4057qib7 13325 19 68 68 CD cord-005453-4057qib7 13325 20 ) ) -RRB- cord-005453-4057qib7 13325 21 from from IN cord-005453-4057qib7 13325 22 unrelated unrelated JJ cord-005453-4057qib7 13325 23 donors donor NNS cord-005453-4057qib7 13325 24 and and CC cord-005453-4057qib7 13325 25 1 1 CD cord-005453-4057qib7 13325 26 patient patient NN cord-005453-4057qib7 13325 27 from from IN cord-005453-4057qib7 13325 28 haploidentical haploidentical JJ cord-005453-4057qib7 13325 29 donor donor NN cord-005453-4057qib7 13325 30 . . . cord-005453-4057qib7 13326 1 We -PRON- PRP cord-005453-4057qib7 13326 2 used use VBD cord-005453-4057qib7 13326 3 busulfan busulfan NN cord-005453-4057qib7 13326 4 - - HYPH cord-005453-4057qib7 13326 5 based base VBN cord-005453-4057qib7 13326 6 myeloablative myeloablative NNP cord-005453-4057qib7 13326 7 conditioning conditioning NN cord-005453-4057qib7 13326 8 regimen regimen NN cord-005453-4057qib7 13326 9 to to IN cord-005453-4057qib7 13326 10 12 12 CD cord-005453-4057qib7 13326 11 patients patient NNS cord-005453-4057qib7 13326 12 ( ( -LRB- cord-005453-4057qib7 13326 13 % % NN cord-005453-4057qib7 13326 14 75 75 CD cord-005453-4057qib7 13326 15 ) ) -RRB- cord-005453-4057qib7 13326 16 , , , cord-005453-4057qib7 13326 17 reduced reduce VBN cord-005453-4057qib7 13326 18 toxicity toxicity NN cord-005453-4057qib7 13326 19 myeloablative myeloablative JJ cord-005453-4057qib7 13326 20 regimen regimen NN cord-005453-4057qib7 13326 21 with with IN cord-005453-4057qib7 13326 22 treosulfan treosulfan NNP cord-005453-4057qib7 13326 23 to to IN cord-005453-4057qib7 13326 24 2 2 CD cord-005453-4057qib7 13326 25 patients patient NNS cord-005453-4057qib7 13326 26 ( ( -LRB- cord-005453-4057qib7 13326 27 % % NN cord-005453-4057qib7 13326 28 12.5 12.5 CD cord-005453-4057qib7 13326 29 ) ) -RRB- cord-005453-4057qib7 13326 30 and and CC cord-005453-4057qib7 13326 31 nonmyeloablative nonmyeloablative JJ cord-005453-4057qib7 13326 32 regimen regimen NN cord-005453-4057qib7 13326 33 to to IN cord-005453-4057qib7 13326 34 2 2 CD cord-005453-4057qib7 13326 35 patients patient NNS cord-005453-4057qib7 13326 36 ( ( -LRB- cord-005453-4057qib7 13326 37 % % NN cord-005453-4057qib7 13326 38 12.5 12.5 CD cord-005453-4057qib7 13326 39 ) ) -RRB- cord-005453-4057qib7 13326 40 . . . cord-005453-4057qib7 13327 1 Eight eight CD cord-005453-4057qib7 13327 2 of of IN cord-005453-4057qib7 13327 3 the the DT cord-005453-4057qib7 13327 4 recipients recipient NNS cord-005453-4057qib7 13327 5 received receive VBD cord-005453-4057qib7 13327 6 bone bone NN cord-005453-4057qib7 13327 7 marrow marrow NN cord-005453-4057qib7 13327 8 , , , cord-005453-4057qib7 13327 9 6 6 CD cord-005453-4057qib7 13327 10 of of IN cord-005453-4057qib7 13327 11 the the DT cord-005453-4057qib7 13327 12 patients patient NNS cord-005453-4057qib7 13327 13 received receive VBD cord-005453-4057qib7 13327 14 peripheral peripheral JJ cord-005453-4057qib7 13327 15 blood blood NN cord-005453-4057qib7 13327 16 stem stem NN cord-005453-4057qib7 13327 17 cells cell NNS cord-005453-4057qib7 13327 18 , , , cord-005453-4057qib7 13327 19 2 2 CD cord-005453-4057qib7 13327 20 of of IN cord-005453-4057qib7 13327 21 the the DT cord-005453-4057qib7 13327 22 recipients recipient NNS cord-005453-4057qib7 13327 23 received receive VBD cord-005453-4057qib7 13327 24 cord cord NN cord-005453-4057qib7 13327 25 blood blood NN cord-005453-4057qib7 13327 26 as as IN cord-005453-4057qib7 13327 27 stem stem NN cord-005453-4057qib7 13327 28 cell cell NN cord-005453-4057qib7 13327 29 source source NN cord-005453-4057qib7 13327 30 . . . cord-005453-4057qib7 13328 1 Fifteen fifteen CD cord-005453-4057qib7 13328 2 of of IN cord-005453-4057qib7 13328 3 16 16 CD cord-005453-4057qib7 13328 4 patients patient NNS cord-005453-4057qib7 13328 5 ( ( -LRB- cord-005453-4057qib7 13328 6 % % NN cord-005453-4057qib7 13328 7 93 93 CD cord-005453-4057qib7 13328 8 ) ) -RRB- cord-005453-4057qib7 13328 9 had have VBD cord-005453-4057qib7 13328 10 achieved achieve VBN cord-005453-4057qib7 13329 1 engraftment engraftment NNP cord-005453-4057qib7 13329 2 and and CC cord-005453-4057qib7 13329 3 median median JJ cord-005453-4057qib7 13329 4 follow follow NN cord-005453-4057qib7 13329 5 - - HYPH cord-005453-4057qib7 13329 6 up up NN cord-005453-4057qib7 13329 7 of of IN cord-005453-4057qib7 13329 8 patients patient NNS cord-005453-4057qib7 13329 9 was be VBD cord-005453-4057qib7 13329 10 29 29 CD cord-005453-4057qib7 13329 11 months month NNS cord-005453-4057qib7 13329 12 ( ( -LRB- cord-005453-4057qib7 13329 13 1 1 CD cord-005453-4057qib7 13329 14 - - SYM cord-005453-4057qib7 13329 15 64 64 CD cord-005453-4057qib7 13329 16 ) ) -RRB- cord-005453-4057qib7 13329 17 . . . cord-005453-4057qib7 13330 1 Grade grade NN cord-005453-4057qib7 13330 2 III III NNP cord-005453-4057qib7 13330 3 - - HYPH cord-005453-4057qib7 13330 4 IV IV NNP cord-005453-4057qib7 13330 5 acute acute JJ cord-005453-4057qib7 13330 6 graft graft NN cord-005453-4057qib7 13330 7 versus versus IN cord-005453-4057qib7 13330 8 host host NN cord-005453-4057qib7 13330 9 disease disease NN cord-005453-4057qib7 13330 10 ( ( -LRB- cord-005453-4057qib7 13330 11 GVHD GVHD NNP cord-005453-4057qib7 13330 12 ) ) -RRB- cord-005453-4057qib7 13330 13 occurred occur VBD cord-005453-4057qib7 13330 14 in in IN cord-005453-4057qib7 13330 15 13 13 CD cord-005453-4057qib7 13330 16 % % NN cord-005453-4057qib7 13330 17 of of IN cord-005453-4057qib7 13330 18 patients patient NNS cord-005453-4057qib7 13330 19 and and CC cord-005453-4057qib7 13330 20 chronic chronic JJ cord-005453-4057qib7 13330 21 graft graft NN cord-005453-4057qib7 13330 22 versus versus IN cord-005453-4057qib7 13330 23 host host NN cord-005453-4057qib7 13330 24 disease disease NN cord-005453-4057qib7 13330 25 was be VBD cord-005453-4057qib7 13330 26 seen see VBN cord-005453-4057qib7 13330 27 18 18 CD cord-005453-4057qib7 13330 28 % % NN cord-005453-4057qib7 13330 29 of of IN cord-005453-4057qib7 13330 30 patients patient NNS cord-005453-4057qib7 13330 31 . . . cord-005453-4057qib7 13331 1 One one CD cord-005453-4057qib7 13331 2 patient patient NN cord-005453-4057qib7 13331 3 received receive VBD cord-005453-4057qib7 13331 4 cord cord NN cord-005453-4057qib7 13331 5 blood blood NN cord-005453-4057qib7 13331 6 from from IN cord-005453-4057qib7 13331 7 unrelated unrelated JJ cord-005453-4057qib7 13331 8 donor donor NN cord-005453-4057qib7 13331 9 did do VBD cord-005453-4057qib7 13331 10 not not RB cord-005453-4057qib7 13331 11 engraft engraft VB cord-005453-4057qib7 13331 12 and and CC cord-005453-4057qib7 13331 13 died die VBD cord-005453-4057qib7 13331 14 from from IN cord-005453-4057qib7 13331 15 septic septic JJ cord-005453-4057qib7 13331 16 shock shock NN cord-005453-4057qib7 13331 17 . . . cord-005453-4057qib7 13332 1 Four four CD cord-005453-4057qib7 13332 2 patients patient NNS cord-005453-4057qib7 13332 3 died die VBD cord-005453-4057qib7 13332 4 from from IN cord-005453-4057qib7 13332 5 transplant transplant NN cord-005453-4057qib7 13332 6 related relate VBN cord-005453-4057qib7 13332 7 toxicity toxicity NN cord-005453-4057qib7 13332 8 . . . cord-005453-4057qib7 13333 1 Our -PRON- PRP$ cord-005453-4057qib7 13333 2 patient patient NN cord-005453-4057qib7 13333 3 's 's POS cord-005453-4057qib7 13333 4 survival survival NN cord-005453-4057qib7 13333 5 was be VBD cord-005453-4057qib7 13333 6 % % NN cord-005453-4057qib7 13333 7 68 68 CD cord-005453-4057qib7 13333 8 ; ; : cord-005453-4057qib7 13333 9 11/16 11/16 CD cord-005453-4057qib7 13333 10 patients patient NNS cord-005453-4057qib7 13333 11 alive alive JJ cord-005453-4057qib7 13333 12 . . . cord-005453-4057qib7 13334 1 Conclusions conclusion NNS cord-005453-4057qib7 13334 2 : : : cord-005453-4057qib7 13335 1 HSCT HSCT NNP cord-005453-4057qib7 13335 2 is be VBZ cord-005453-4057qib7 13335 3 the the DT cord-005453-4057qib7 13335 4 only only JJ cord-005453-4057qib7 13335 5 curative curative JJ cord-005453-4057qib7 13335 6 treatment treatment NN cord-005453-4057qib7 13335 7 option option NN cord-005453-4057qib7 13335 8 for for IN cord-005453-4057qib7 13335 9 DOCK8 DOCK8 NNP cord-005453-4057qib7 13335 10 deficiency deficiency NN cord-005453-4057qib7 13335 11 . . . cord-005453-4057qib7 13336 1 In in IN cord-005453-4057qib7 13336 2 particular particular JJ cord-005453-4057qib7 13336 3 , , , cord-005453-4057qib7 13336 4 patients patient NNS cord-005453-4057qib7 13336 5 with with IN cord-005453-4057qib7 13336 6 high high JJ cord-005453-4057qib7 13336 7 comorbidity comorbidity NN cord-005453-4057qib7 13336 8 scores score NNS cord-005453-4057qib7 13336 9 have have VBP cord-005453-4057qib7 13336 10 a a DT cord-005453-4057qib7 13336 11 high high JJ cord-005453-4057qib7 13336 12 risk risk NN cord-005453-4057qib7 13336 13 of of IN cord-005453-4057qib7 13336 14 toxicity toxicity NN cord-005453-4057qib7 13336 15 and and CC cord-005453-4057qib7 13336 16 toxic toxic JJ cord-005453-4057qib7 13336 17 death death NN cord-005453-4057qib7 13336 18 . . . cord-005453-4057qib7 13337 1 Therefore therefore RB cord-005453-4057qib7 13337 2 , , , cord-005453-4057qib7 13337 3 reduced reduce VBN cord-005453-4057qib7 13337 4 toxicity toxicity NN cord-005453-4057qib7 13337 5 conditioning conditioning NN cord-005453-4057qib7 13337 6 regimens regimen NNS cord-005453-4057qib7 13337 7 should should MD cord-005453-4057qib7 13337 8 be be VB cord-005453-4057qib7 13337 9 used use VBN cord-005453-4057qib7 13337 10 for for IN cord-005453-4057qib7 13337 11 these these DT cord-005453-4057qib7 13337 12 patients patient NNS cord-005453-4057qib7 13337 13 . . . cord-005453-4057qib7 13338 1 References reference NNS cord-005453-4057qib7 13338 2 : : : cord-005453-4057qib7 13339 1 Background background NN cord-005453-4057qib7 13339 2 : : : cord-005453-4057qib7 13339 3 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 13339 4 , , , cord-005453-4057qib7 13339 5 a a DT cord-005453-4057qib7 13339 6 low low JJ cord-005453-4057qib7 13339 7 - - HYPH cord-005453-4057qib7 13339 8 molecular molecular JJ cord-005453-4057qib7 13339 9 - - HYPH cord-005453-4057qib7 13339 10 weight weight NN cord-005453-4057qib7 13339 11 synthetic synthetic NN cord-005453-4057qib7 13339 12 nonpeptide nonpeptide NNP cord-005453-4057qib7 13339 13 thrombopoietin thrombopoietin NNP cord-005453-4057qib7 13339 14 receptor receptor NN cord-005453-4057qib7 13339 15 agonist agonist NN cord-005453-4057qib7 13340 1 ( ( -LRB- cord-005453-4057qib7 13340 2 TPO TPO NNP cord-005453-4057qib7 13340 3 - - HYPH cord-005453-4057qib7 13340 4 R R NNP cord-005453-4057qib7 13340 5 ) ) -RRB- cord-005453-4057qib7 13340 6 , , , cord-005453-4057qib7 13340 7 is be VBZ cord-005453-4057qib7 13340 8 a a DT cord-005453-4057qib7 13340 9 second second JJ cord-005453-4057qib7 13340 10 - - HYPH cord-005453-4057qib7 13340 11 generation generation NN cord-005453-4057qib7 13340 12 TPO TPO NNP cord-005453-4057qib7 13340 13 . . . cord-005453-4057qib7 13341 1 It -PRON- PRP cord-005453-4057qib7 13341 2 is be VBZ cord-005453-4057qib7 13341 3 an an DT cord-005453-4057qib7 13341 4 oral oral JJ cord-005453-4057qib7 13341 5 thrombopoietin thrombopoietin XX cord-005453-4057qib7 13341 6 mimetic mimetic NN cord-005453-4057qib7 13341 7 licensed license VBN cord-005453-4057qib7 13341 8 in in IN cord-005453-4057qib7 13341 9 chronic chronic JJ cord-005453-4057qib7 13341 10 immune immune JJ cord-005453-4057qib7 13341 11 thrombocytopenic thrombocytopenic JJ cord-005453-4057qib7 13341 12 purpura purpura NN cord-005453-4057qib7 13341 13 that that WDT cord-005453-4057qib7 13341 14 induces induce VBZ cord-005453-4057qib7 13341 15 platelet platelet NN cord-005453-4057qib7 13341 16 maturation maturation NN cord-005453-4057qib7 13341 17 and and CC cord-005453-4057qib7 13341 18 release release NN cord-005453-4057qib7 13341 19 by by IN cord-005453-4057qib7 13341 20 binding bind VBG cord-005453-4057qib7 13341 21 to to IN cord-005453-4057qib7 13341 22 c c NNP cord-005453-4057qib7 13341 23 - - HYPH cord-005453-4057qib7 13341 24 MPL MPL NNP cord-005453-4057qib7 13341 25 receptors receptor NNS cord-005453-4057qib7 13341 26 on on IN cord-005453-4057qib7 13341 27 megakaryocytes megakaryocyte NNS cord-005453-4057qib7 13341 28 . . . cord-005453-4057qib7 13342 1 In in IN cord-005453-4057qib7 13342 2 a a DT cord-005453-4057qib7 13342 3 recent recent JJ cord-005453-4057qib7 13342 4 study study NN cord-005453-4057qib7 13342 5 ; ; : cord-005453-4057qib7 13342 6 for for IN cord-005453-4057qib7 13342 7 patients patient NNS cord-005453-4057qib7 13342 8 with with IN cord-005453-4057qib7 13342 9 refractory refractory JJ cord-005453-4057qib7 13342 10 SAA SAA NNP cord-005453-4057qib7 13342 11 , , , cord-005453-4057qib7 13342 12 eltrombopag eltrombopag NNP cord-005453-4057qib7 13342 13 induced induce VBD cord-005453-4057qib7 13342 14 a a DT cord-005453-4057qib7 13342 15 response response NN cord-005453-4057qib7 13342 16 ( ( -LRB- cord-005453-4057qib7 13342 17 at at IN cord-005453-4057qib7 13342 18 12 12 CD cord-005453-4057qib7 13342 19 weeks week NNS cord-005453-4057qib7 13342 20 ) ) -RRB- cord-005453-4057qib7 13342 21 in in IN cord-005453-4057qib7 13342 22 at at RB cord-005453-4057qib7 13342 23 least least RBS cord-005453-4057qib7 13342 24 one one CD cord-005453-4057qib7 13342 25 hematologic hematologic JJ cord-005453-4057qib7 13342 26 lineage lineage NN cord-005453-4057qib7 13342 27 in in IN cord-005453-4057qib7 13342 28 44 44 CD cord-005453-4057qib7 13342 29 % % NN cord-005453-4057qib7 13342 30 patients patient NNS cord-005453-4057qib7 13342 31 and and CC cord-005453-4057qib7 13342 32 36 36 CD cord-005453-4057qib7 13342 33 % % NN cord-005453-4057qib7 13342 34 no no RB cord-005453-4057qib7 13342 35 longer longer RB cord-005453-4057qib7 13342 36 required require VBN cord-005453-4057qib7 13342 37 platelet platelet NN cord-005453-4057qib7 13342 38 transfusions transfusion NNS cord-005453-4057qib7 13342 39 . . . cord-005453-4057qib7 13343 1 And and CC cord-005453-4057qib7 13343 2 also also RB cord-005453-4057qib7 13343 3 24 24 CD cord-005453-4057qib7 13343 4 % % NN cord-005453-4057qib7 13343 5 patients patient NNS cord-005453-4057qib7 13343 6 became become VBD cord-005453-4057qib7 13343 7 RBC RBC NNP cord-005453-4057qib7 13343 8 transfusion transfusion NN cord-005453-4057qib7 13343 9 independent independent JJ cord-005453-4057qib7 13343 10 and and CC cord-005453-4057qib7 13343 11 36 36 CD cord-005453-4057qib7 13343 12 % % NN cord-005453-4057qib7 13343 13 had have VBD cord-005453-4057qib7 13343 14 a a DT cord-005453-4057qib7 13343 15 neutrophil neutrophil NN cord-005453-4057qib7 13343 16 response response NN cord-005453-4057qib7 13343 17 . . . cord-005453-4057qib7 13344 1 Trilineage trilineage NN cord-005453-4057qib7 13344 2 responses response NNS cord-005453-4057qib7 13344 3 were be VBD cord-005453-4057qib7 13344 4 seen see VBN cord-005453-4057qib7 13344 5 in in IN cord-005453-4057qib7 13344 6 24 24 CD cord-005453-4057qib7 13344 7 % % NN cord-005453-4057qib7 13344 8 of of IN cord-005453-4057qib7 13344 9 patients patient NNS cord-005453-4057qib7 13344 10 ; ; : cord-005453-4057qib7 13344 11 although although IN cord-005453-4057qib7 13344 12 surprising surprising JJ cord-005453-4057qib7 13344 13 , , , cord-005453-4057qib7 13344 14 this this DT cord-005453-4057qib7 13344 15 might may MD cord-005453-4057qib7 13344 16 indicate indicate VB cord-005453-4057qib7 13344 17 stimulation stimulation NN cord-005453-4057qib7 13344 18 of of IN cord-005453-4057qib7 13344 19 c c NNP cord-005453-4057qib7 13344 20 - - HYPH cord-005453-4057qib7 13344 21 MPL MPL NNP cord-005453-4057qib7 13344 22 receptors receptor NNS cord-005453-4057qib7 13344 23 on on IN cord-005453-4057qib7 13344 24 remaining remain VBG cord-005453-4057qib7 13344 25 stem stem NN cord-005453-4057qib7 13344 26 cells cell NNS cord-005453-4057qib7 13344 27 . . . cord-005453-4057qib7 13345 1 Delayed delay VBN cord-005453-4057qib7 13345 2 recovery recovery NN cord-005453-4057qib7 13345 3 from from IN cord-005453-4057qib7 13345 4 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 13345 5 is be VBZ cord-005453-4057qib7 13345 6 common common JJ cord-005453-4057qib7 13345 7 after after IN cord-005453-4057qib7 13345 8 stem stem NN cord-005453-4057qib7 13345 9 cell cell NN cord-005453-4057qib7 13345 10 transplantation transplantation NN cord-005453-4057qib7 13345 11 . . . cord-005453-4057qib7 13346 1 In in IN cord-005453-4057qib7 13346 2 a a DT cord-005453-4057qib7 13346 3 study study NN cord-005453-4057qib7 13346 4 including include VBG cord-005453-4057qib7 13346 5 12 12 CD cord-005453-4057qib7 13346 6 adult adult NN cord-005453-4057qib7 13346 7 patients patient NNS cord-005453-4057qib7 13346 8 , , , cord-005453-4057qib7 13346 9 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 13346 10 was be VBD cord-005453-4057qib7 13346 11 used use VBN cord-005453-4057qib7 13346 12 to to TO cord-005453-4057qib7 13346 13 enhance enhance VB cord-005453-4057qib7 13346 14 platelet platelet NN cord-005453-4057qib7 13346 15 recovery recovery NN cord-005453-4057qib7 13346 16 for for IN cord-005453-4057qib7 13346 17 post post JJ cord-005453-4057qib7 13346 18 - - JJ cord-005453-4057qib7 13346 19 HSCT hsct JJ cord-005453-4057qib7 13346 20 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 13346 21 . . . cord-005453-4057qib7 13347 1 It -PRON- PRP cord-005453-4057qib7 13347 2 is be VBZ cord-005453-4057qib7 13347 3 well well RB cord-005453-4057qib7 13347 4 tolerated tolerate VBN cord-005453-4057qib7 13347 5 and and CC cord-005453-4057qib7 13347 6 efficacious efficacious JJ cord-005453-4057qib7 13347 7 offering offer VBG cord-005453-4057qib7 13347 8 transfusion transfusion NN cord-005453-4057qib7 13347 9 independence independence NN cord-005453-4057qib7 13347 10 . . . cord-005453-4057qib7 13348 1 Methods method NNS cord-005453-4057qib7 13348 2 : : : cord-005453-4057qib7 13348 3 In in IN cord-005453-4057qib7 13348 4 our -PRON- PRP$ cord-005453-4057qib7 13348 5 retrospective retrospective JJ cord-005453-4057qib7 13348 6 study study NN cord-005453-4057qib7 13348 7 , , , cord-005453-4057qib7 13348 8 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 13348 9 ( ( -LRB- cord-005453-4057qib7 13348 10 50mg 50mg NNP cord-005453-4057qib7 13348 11 / / SYM cord-005453-4057qib7 13348 12 day day NN cord-005453-4057qib7 13348 13 ) ) -RRB- cord-005453-4057qib7 13348 14 was be VBD cord-005453-4057qib7 13348 15 started start VBN cord-005453-4057qib7 13348 16 in in IN cord-005453-4057qib7 13348 17 19 19 CD cord-005453-4057qib7 13348 18 pediatric pediatric JJ cord-005453-4057qib7 13348 19 patients patient NNS cord-005453-4057qib7 13348 20 ( ( -LRB- cord-005453-4057qib7 13348 21 age age NN cord-005453-4057qib7 13348 22 ranging range VBG cord-005453-4057qib7 13348 23 from from IN cord-005453-4057qib7 13348 24 4 4 CD cord-005453-4057qib7 13348 25 to to TO cord-005453-4057qib7 13348 26 16 16 CD cord-005453-4057qib7 13348 27 years year NNS cord-005453-4057qib7 13348 28 with with IN cord-005453-4057qib7 13348 29 a a DT cord-005453-4057qib7 13348 30 median median JJ cord-005453-4057qib7 13348 31 age age NN cord-005453-4057qib7 13348 32 12.3 12.3 CD cord-005453-4057qib7 13348 33 years year NNS cord-005453-4057qib7 13348 34 ) ) -RRB- cord-005453-4057qib7 13348 35 for for IN cord-005453-4057qib7 13348 36 posthematopoietic posthematopoietic NNP cord-005453-4057qib7 13348 37 stem stem NN cord-005453-4057qib7 13348 38 cell cell NN cord-005453-4057qib7 13348 39 transplantation transplantation NN cord-005453-4057qib7 13348 40 ( ( -LRB- cord-005453-4057qib7 13348 41 HSCT HSCT NNP cord-005453-4057qib7 13348 42 ) ) -RRB- cord-005453-4057qib7 13348 43 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 13348 44 . . . cord-005453-4057qib7 13349 1 All all DT cord-005453-4057qib7 13349 2 patients patient NNS cord-005453-4057qib7 13349 3 fulfilled fulfil VBD cord-005453-4057qib7 13349 4 the the DT cord-005453-4057qib7 13349 5 following following JJ cord-005453-4057qib7 13349 6 3 3 CD cord-005453-4057qib7 13349 7 criteria criterion NNS cord-005453-4057qib7 13349 8 : : : cord-005453-4057qib7 13349 9 ( ( -LRB- cord-005453-4057qib7 13349 10 1 1 LS cord-005453-4057qib7 13349 11 ) ) -RRB- cord-005453-4057qib7 13349 12 undergone undergo VBN cord-005453-4057qib7 13349 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 13349 14 stem stem NN cord-005453-4057qib7 13349 15 cell cell NN cord-005453-4057qib7 13349 16 transplantation transplantation NN cord-005453-4057qib7 13349 17 ( ( -LRB- cord-005453-4057qib7 13349 18 HSCT HSCT NNP cord-005453-4057qib7 13349 19 ) ) -RRB- cord-005453-4057qib7 13349 20 , , , cord-005453-4057qib7 13349 21 ( ( -LRB- cord-005453-4057qib7 13349 22 2 2 LS cord-005453-4057qib7 13349 23 ) ) -RRB- cord-005453-4057qib7 13349 24 had have VBD cord-005453-4057qib7 13349 25 improved improve VBN cord-005453-4057qib7 13349 26 total total JJ cord-005453-4057qib7 13349 27 leucocyte leucocyte NN cord-005453-4057qib7 13349 28 counts count NNS cord-005453-4057qib7 13349 29 after after IN cord-005453-4057qib7 13349 30 leucocyte leucocyte NNP cord-005453-4057qib7 13349 31 engraftment engraftment NNP cord-005453-4057qib7 13349 32 , , , cord-005453-4057qib7 13349 33 ( ( -LRB- cord-005453-4057qib7 13349 34 3 3 LS cord-005453-4057qib7 13349 35 ) ) -RRB- cord-005453-4057qib7 13349 36 had have VBD cord-005453-4057qib7 13349 37 prolonged prolong VBN cord-005453-4057qib7 13349 38 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 13349 39 ( ( -LRB- cord-005453-4057qib7 13349 40 < < XX cord-005453-4057qib7 13349 41 30.000 30.000 CD cord-005453-4057qib7 13349 42 ) ) -RRB- cord-005453-4057qib7 13349 43 needing need VBG cord-005453-4057qib7 13349 44 platelet platelet NN cord-005453-4057qib7 13349 45 transfusion transfusion NN cord-005453-4057qib7 13349 46 . . . cord-005453-4057qib7 13350 1 Results result NNS cord-005453-4057qib7 13350 2 : : : cord-005453-4057qib7 13351 1 Four four CD cord-005453-4057qib7 13351 2 of of IN cord-005453-4057qib7 13351 3 the the DT cord-005453-4057qib7 13351 4 patients patient NNS cord-005453-4057qib7 13351 5 have have VBP cord-005453-4057qib7 13351 6 received receive VBN cord-005453-4057qib7 13351 7 RIC RIC NNP cord-005453-4057qib7 13351 8 while while IN cord-005453-4057qib7 13351 9 15 15 CD cord-005453-4057qib7 13351 10 patients patient NNS cord-005453-4057qib7 13351 11 MA MA NNP cord-005453-4057qib7 13351 12 conditioning conditioning NN cord-005453-4057qib7 13351 13 regimens regimen NNS cord-005453-4057qib7 13351 14 before before IN cord-005453-4057qib7 13351 15 HSCT HSCT NNP cord-005453-4057qib7 13351 16 . . . cord-005453-4057qib7 13352 1 Two two CD cord-005453-4057qib7 13352 2 haploidentic haploidentic NN cord-005453-4057qib7 13352 3 , , , cord-005453-4057qib7 13352 4 2 2 CD cord-005453-4057qib7 13352 5 autologous autologous JJ cord-005453-4057qib7 13352 6 , , , cord-005453-4057qib7 13352 7 7 7 CD cord-005453-4057qib7 13352 8 MUD mud NN cord-005453-4057qib7 13352 9 , , , cord-005453-4057qib7 13352 10 8 8 CD cord-005453-4057qib7 13352 11 MSD MSD NNP cord-005453-4057qib7 13352 12 transplantations transplantation NNS cord-005453-4057qib7 13352 13 were be VBD cord-005453-4057qib7 13352 14 performed perform VBN cord-005453-4057qib7 13352 15 . . . cord-005453-4057qib7 13353 1 ET ET NNP cord-005453-4057qib7 13353 2 ( ( -LRB- cord-005453-4057qib7 13353 3 50mg 50mg NNP cord-005453-4057qib7 13353 4 / / SYM cord-005453-4057qib7 13353 5 day day NN cord-005453-4057qib7 13353 6 ) ) -RRB- cord-005453-4057qib7 13353 7 was be VBD cord-005453-4057qib7 13353 8 started start VBN cord-005453-4057qib7 13353 9 in in IN cord-005453-4057qib7 13353 10 19 19 CD cord-005453-4057qib7 13353 11 patients patient NNS cord-005453-4057qib7 13353 12 who who WP cord-005453-4057qib7 13353 13 had have VBD cord-005453-4057qib7 13353 14 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 13353 15 despite despite IN cord-005453-4057qib7 13353 16 neutrophil neutrophil NN cord-005453-4057qib7 13353 17 engraftment engraftment NN cord-005453-4057qib7 13353 18 on on IN cord-005453-4057qib7 13353 19 the the DT cord-005453-4057qib7 13353 20 +30th +30th NNP cord-005453-4057qib7 13353 21 day day NN cord-005453-4057qib7 13353 22 of of IN cord-005453-4057qib7 13353 23 HSCT HSCT NNP cord-005453-4057qib7 13353 24 A a DT cord-005453-4057qib7 13353 25 reduction reduction NN cord-005453-4057qib7 13353 26 in in IN cord-005453-4057qib7 13353 27 platelet platelet NN cord-005453-4057qib7 13353 28 transfusions transfusion NNS cord-005453-4057qib7 13353 29 and and CC cord-005453-4057qib7 13353 30 a a DT cord-005453-4057qib7 13353 31 platelet platelet NN cord-005453-4057qib7 13353 32 count count NN cord-005453-4057qib7 13353 33 of of IN cord-005453-4057qib7 13353 34 more more JJR cord-005453-4057qib7 13353 35 than than IN cord-005453-4057qib7 13353 36 30,000 30,000 CD cord-005453-4057qib7 13353 37 were be VBD cord-005453-4057qib7 13353 38 the the DT cord-005453-4057qib7 13353 39 primary primary JJ cord-005453-4057qib7 13353 40 endpoints endpoint NNS cord-005453-4057qib7 13353 41 . . . cord-005453-4057qib7 13354 1 Before before IN cord-005453-4057qib7 13354 2 ET ET NNP cord-005453-4057qib7 13354 3 treatment treatment NN cord-005453-4057qib7 13354 4 , , , cord-005453-4057qib7 13354 5 bone bone NN cord-005453-4057qib7 13354 6 marrow marrow NN cord-005453-4057qib7 13354 7 biopsy biopsy NN cord-005453-4057qib7 13354 8 was be VBD cord-005453-4057qib7 13354 9 checked check VBN cord-005453-4057qib7 13354 10 in in IN cord-005453-4057qib7 13354 11 15/19 15/19 CD cord-005453-4057qib7 13354 12 patients patient NNS cord-005453-4057qib7 13354 13 , , , cord-005453-4057qib7 13354 14 10/15 10/15 CD cord-005453-4057qib7 13354 15 patients patient NNS cord-005453-4057qib7 13354 16 had have VBD cord-005453-4057qib7 13354 17 decreased decrease VBN cord-005453-4057qib7 13354 18 number number NN cord-005453-4057qib7 13354 19 of of IN cord-005453-4057qib7 13354 20 megacocyocytes megacocyocyte NNS cord-005453-4057qib7 13354 21 . . . cord-005453-4057qib7 13355 1 None none NN cord-005453-4057qib7 13355 2 of of IN cord-005453-4057qib7 13355 3 the the DT cord-005453-4057qib7 13355 4 patients patient NNS cord-005453-4057qib7 13355 5 had have VBD cord-005453-4057qib7 13355 6 active active JJ cord-005453-4057qib7 13355 7 bleeding bleeding NN cord-005453-4057qib7 13355 8 at at IN cord-005453-4057qib7 13355 9 the the DT cord-005453-4057qib7 13355 10 start start NN cord-005453-4057qib7 13355 11 of of IN cord-005453-4057qib7 13355 12 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 13355 13 but but CC cord-005453-4057qib7 13355 14 they -PRON- PRP cord-005453-4057qib7 13355 15 were be VBD cord-005453-4057qib7 13355 16 all all RB cord-005453-4057qib7 13355 17 at at IN cord-005453-4057qib7 13355 18 high high JJ cord-005453-4057qib7 13355 19 risk risk NN cord-005453-4057qib7 13355 20 of of IN cord-005453-4057qib7 13355 21 bleeding bleed VBG cord-005453-4057qib7 13355 22 . . . cord-005453-4057qib7 13356 1 According accord VBG cord-005453-4057qib7 13356 2 to to IN cord-005453-4057qib7 13356 3 the the DT cord-005453-4057qib7 13356 4 platelet platelet NN cord-005453-4057qib7 13356 5 monitoring monitoring NN cord-005453-4057qib7 13356 6 , , , cord-005453-4057qib7 13356 7 12 12 CD cord-005453-4057qib7 13356 8 patients patient NNS cord-005453-4057qib7 13356 9 had have VBD cord-005453-4057qib7 13356 10 a a DT cord-005453-4057qib7 13356 11 dose dose JJ cord-005453-4057qib7 13356 12 increase increase NN cord-005453-4057qib7 13356 13 starting start VBG cord-005453-4057qib7 13356 14 from from IN cord-005453-4057qib7 13356 15 the the DT cord-005453-4057qib7 13356 16 second second JJ cord-005453-4057qib7 13356 17 week week NN cord-005453-4057qib7 13356 18 . . . cord-005453-4057qib7 13357 1 The the DT cord-005453-4057qib7 13357 2 number number NN cord-005453-4057qib7 13357 3 of of IN cord-005453-4057qib7 13357 4 patients patient NNS cord-005453-4057qib7 13357 5 in in IN cord-005453-4057qib7 13357 6 need need NN cord-005453-4057qib7 13357 7 of of IN cord-005453-4057qib7 13357 8 platelet platelet NN cord-005453-4057qib7 13357 9 transfusions transfusion NNS cord-005453-4057qib7 13357 10 was be VBD cord-005453-4057qib7 13357 11 7 7 CD cord-005453-4057qib7 13357 12 at at IN cord-005453-4057qib7 13357 13 the the DT cord-005453-4057qib7 13357 14 end end NN cord-005453-4057qib7 13357 15 of of IN cord-005453-4057qib7 13357 16 the the DT cord-005453-4057qib7 13357 17 first first JJ cord-005453-4057qib7 13357 18 month month NN cord-005453-4057qib7 13357 19 ; ; : cord-005453-4057qib7 13357 20 and and CC cord-005453-4057qib7 13357 21 only only RB cord-005453-4057qib7 13357 22 2 2 CD cord-005453-4057qib7 13357 23 at at IN cord-005453-4057qib7 13357 24 the the DT cord-005453-4057qib7 13357 25 end end NN cord-005453-4057qib7 13357 26 of of IN cord-005453-4057qib7 13357 27 the the DT cord-005453-4057qib7 13357 28 2nd 2nd JJ cord-005453-4057qib7 13357 29 month month NN cord-005453-4057qib7 13357 30 . . . cord-005453-4057qib7 13358 1 All all DT cord-005453-4057qib7 13358 2 patients patient NNS cord-005453-4057qib7 13358 3 had have VBD cord-005453-4057qib7 13358 4 a a DT cord-005453-4057qib7 13358 5 thrombocyte thrombocyte NN cord-005453-4057qib7 13358 6 count count NN cord-005453-4057qib7 13358 7 of of IN cord-005453-4057qib7 13358 8 more more JJR cord-005453-4057qib7 13358 9 than than IN cord-005453-4057qib7 13358 10 30.000 30.000 CD cord-005453-4057qib7 13358 11 in in IN cord-005453-4057qib7 13358 12 the the DT cord-005453-4057qib7 13358 13 third third JJ cord-005453-4057qib7 13358 14 month month NN cord-005453-4057qib7 13358 15 . . . cord-005453-4057qib7 13359 1 In in IN cord-005453-4057qib7 13359 2 11 11 CD cord-005453-4057qib7 13359 3 patients patient NNS cord-005453-4057qib7 13359 4 , , , cord-005453-4057qib7 13359 5 ET ET NNP cord-005453-4057qib7 13359 6 was be VBD cord-005453-4057qib7 13359 7 discontinued discontinue VBN cord-005453-4057qib7 13359 8 after after IN cord-005453-4057qib7 13359 9 2 2 CD cord-005453-4057qib7 13359 10 - - SYM cord-005453-4057qib7 13359 11 11 11 CD cord-005453-4057qib7 13359 12 months month NNS cord-005453-4057qib7 13359 13 . . . cord-005453-4057qib7 13360 1 No no DT cord-005453-4057qib7 13360 2 dose dose NN cord-005453-4057qib7 13360 3 limiting limit VBG cord-005453-4057qib7 13360 4 toxicities toxicity NNS cord-005453-4057qib7 13360 5 have have VBP cord-005453-4057qib7 13360 6 been be VBN cord-005453-4057qib7 13360 7 observed observe VBN cord-005453-4057qib7 13360 8 . . . cord-005453-4057qib7 13361 1 Conclusions conclusion NNS cord-005453-4057qib7 13361 2 : : : cord-005453-4057qib7 13362 1 As as IN cord-005453-4057qib7 13362 2 a a DT cord-005453-4057qib7 13362 3 conclusion conclusion NN cord-005453-4057qib7 13362 4 , , , cord-005453-4057qib7 13362 5 ET ET NNP cord-005453-4057qib7 13362 6 was be VBD cord-005453-4057qib7 13362 7 found find VBN cord-005453-4057qib7 13362 8 highly highly RB cord-005453-4057qib7 13362 9 effective effective JJ cord-005453-4057qib7 13362 10 for for IN cord-005453-4057qib7 13362 11 postHSCT postHSCT NNP cord-005453-4057qib7 13362 12 thrombocytopenia thrombocytopenia NNP cord-005453-4057qib7 13362 13 , , , cord-005453-4057qib7 13362 14 with with IN cord-005453-4057qib7 13362 15 no no DT cord-005453-4057qib7 13362 16 drug drug NN cord-005453-4057qib7 13362 17 related relate VBN cord-005453-4057qib7 13362 18 adverse adverse JJ cord-005453-4057qib7 13362 19 effects effect NNS cord-005453-4057qib7 13362 20 . . . cord-005453-4057qib7 13363 1 There there EX cord-005453-4057qib7 13363 2 was be VBD cord-005453-4057qib7 13363 3 a a DT cord-005453-4057qib7 13363 4 gradual gradual JJ cord-005453-4057qib7 13363 5 increase increase NN cord-005453-4057qib7 13363 6 in in IN cord-005453-4057qib7 13363 7 platelet platelet NN cord-005453-4057qib7 13363 8 count count NN cord-005453-4057qib7 13363 9 , , , cord-005453-4057qib7 13363 10 and and CC cord-005453-4057qib7 13363 11 none none NN cord-005453-4057qib7 13363 12 of of IN cord-005453-4057qib7 13363 13 the the DT cord-005453-4057qib7 13363 14 patients patient NNS cord-005453-4057qib7 13363 15 had have VBD cord-005453-4057qib7 13363 16 any any DT cord-005453-4057qib7 13363 17 complication complication NN cord-005453-4057qib7 13363 18 due due IN cord-005453-4057qib7 13363 19 to to IN cord-005453-4057qib7 13363 20 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 13363 21 . . . cord-005453-4057qib7 13364 1 Disclosure disclosure NN cord-005453-4057qib7 13364 2 Background background NN cord-005453-4057qib7 13364 3 : : : cord-005453-4057qib7 13365 1 Isavuconazole Isavuconazole NNP cord-005453-4057qib7 13365 2 ( ( -LRB- cord-005453-4057qib7 13365 3 ISA ISA NNP cord-005453-4057qib7 13365 4 ) ) -RRB- cord-005453-4057qib7 13365 5 is be VBZ cord-005453-4057qib7 13365 6 a a DT cord-005453-4057qib7 13365 7 new new JJ cord-005453-4057qib7 13365 8 triazole triazole NN cord-005453-4057qib7 13365 9 approved approve VBN cord-005453-4057qib7 13365 10 for for IN cord-005453-4057qib7 13365 11 IFI IFI NNP cord-005453-4057qib7 13365 12 treatment treatment NN cord-005453-4057qib7 13365 13 in in IN cord-005453-4057qib7 13365 14 the the DT cord-005453-4057qib7 13365 15 adult adult NN cord-005453-4057qib7 13365 16 population population NN cord-005453-4057qib7 13365 17 . . . cord-005453-4057qib7 13366 1 Advantages advantage NNS cord-005453-4057qib7 13366 2 are be VBP cord-005453-4057qib7 13366 3 activity activity NN cord-005453-4057qib7 13366 4 against against IN cord-005453-4057qib7 13366 5 both both DT cord-005453-4057qib7 13366 6 moulds mould NNS cord-005453-4057qib7 13366 7 and and CC cord-005453-4057qib7 13366 8 yeasts yeast NNS cord-005453-4057qib7 13366 9 spp spp NNS cord-005453-4057qib7 13366 10 , , , cord-005453-4057qib7 13366 11 excellent excellent JJ cord-005453-4057qib7 13366 12 bioavailability bioavailability NN cord-005453-4057qib7 13366 13 after after IN cord-005453-4057qib7 13366 14 oral oral JJ cord-005453-4057qib7 13366 15 administration administration NN cord-005453-4057qib7 13366 16 without without IN cord-005453-4057qib7 13366 17 relevant relevant JJ cord-005453-4057qib7 13366 18 food food NN cord-005453-4057qib7 13366 19 or or CC cord-005453-4057qib7 13366 20 gastric gastric JJ cord-005453-4057qib7 13366 21 pH ph NN cord-005453-4057qib7 13366 22 effect effect NN cord-005453-4057qib7 13366 23 , , , cord-005453-4057qib7 13366 24 a a DT cord-005453-4057qib7 13366 25 water water NN cord-005453-4057qib7 13366 26 - - HYPH cord-005453-4057qib7 13366 27 soluble soluble JJ cord-005453-4057qib7 13366 28 prodrug prodrug NN cord-005453-4057qib7 13366 29 developed develop VBN cord-005453-4057qib7 13366 30 to to TO cord-005453-4057qib7 13366 31 facilitate facilitate VB cord-005453-4057qib7 13366 32 intravenous intravenous JJ cord-005453-4057qib7 13366 33 administration administration NN cord-005453-4057qib7 13366 34 without without IN cord-005453-4057qib7 13366 35 nephrotoxic nephrotoxic NNP cord-005453-4057qib7 13366 36 excipients excipient NNS cord-005453-4057qib7 13366 37 such such JJ cord-005453-4057qib7 13366 38 as as IN cord-005453-4057qib7 13366 39 β β NN cord-005453-4057qib7 13366 40 - - HYPH cord-005453-4057qib7 13366 41 cyclodextrin cyclodextrin NN cord-005453-4057qib7 13366 42 , , , cord-005453-4057qib7 13366 43 potentially potentially RB cord-005453-4057qib7 13366 44 poor poor JJ cord-005453-4057qib7 13366 45 drug drug NN cord-005453-4057qib7 13366 46 - - HYPH cord-005453-4057qib7 13366 47 drug drug NN cord-005453-4057qib7 13366 48 interactions interaction NNS cord-005453-4057qib7 13366 49 . . . cord-005453-4057qib7 13367 1 ISA ISA NNP cord-005453-4057qib7 13367 2 does do VBZ cord-005453-4057qib7 13367 3 not not RB cord-005453-4057qib7 13367 4 currently currently RB cord-005453-4057qib7 13367 5 appear appear VB cord-005453-4057qib7 13367 6 to to TO cord-005453-4057qib7 13367 7 require require VB cord-005453-4057qib7 13367 8 TDM TDM NNP cord-005453-4057qib7 13367 9 . . . cord-005453-4057qib7 13368 1 ISA ISA NNP cord-005453-4057qib7 13368 2 safety safety NN cord-005453-4057qib7 13368 3 and and CC cord-005453-4057qib7 13368 4 efficacy efficacy NN cord-005453-4057qib7 13368 5 have have VBP cord-005453-4057qib7 13368 6 not not RB cord-005453-4057qib7 13368 7 been be VBN cord-005453-4057qib7 13368 8 yet yet RB cord-005453-4057qib7 13368 9 established establish VBN cord-005453-4057qib7 13368 10 in in IN cord-005453-4057qib7 13368 11 children child NNS cord-005453-4057qib7 13368 12 and and CC cord-005453-4057qib7 13368 13 , , , cord-005453-4057qib7 13368 14 in in IN cord-005453-4057qib7 13368 15 particular particular JJ cord-005453-4057qib7 13368 16 , , , cord-005453-4057qib7 13368 17 no no DT cord-005453-4057qib7 13368 18 data datum NNS cord-005453-4057qib7 13368 19 are be VBP cord-005453-4057qib7 13368 20 available available JJ cord-005453-4057qib7 13368 21 in in IN cord-005453-4057qib7 13368 22 the the DT cord-005453-4057qib7 13368 23 pediatric pediatric JJ cord-005453-4057qib7 13368 24 HSCT HSCT NNP cord-005453-4057qib7 13368 25 setting setting NN cord-005453-4057qib7 13368 26 . . . cord-005453-4057qib7 13369 1 Methods method NNS cord-005453-4057qib7 13369 2 : : : cord-005453-4057qib7 13369 3 Italian Italian NNP cord-005453-4057qib7 13369 4 Association Association NNP cord-005453-4057qib7 13369 5 Pediatric Pediatric NNP cord-005453-4057qib7 13369 6 Hematology Hematology NNP cord-005453-4057qib7 13369 7 Oncology Oncology NNP cord-005453-4057qib7 13369 8 ( ( -LRB- cord-005453-4057qib7 13369 9 AIEOP AIEOP NNP cord-005453-4057qib7 13369 10 ) ) -RRB- cord-005453-4057qib7 13369 11 multicentric multicentric NNP cord-005453-4057qib7 13369 12 analysis analysis NN cord-005453-4057qib7 13369 13 of of IN cord-005453-4057qib7 13369 14 a a DT cord-005453-4057qib7 13369 15 cohort cohort NN cord-005453-4057qib7 13369 16 of of IN cord-005453-4057qib7 13369 17 allogeneic allogeneic JJ cord-005453-4057qib7 13369 18 HSCT HSCT NNP cord-005453-4057qib7 13369 19 pediatric pediatric JJ cord-005453-4057qib7 13369 20 patients patient NNS cord-005453-4057qib7 13369 21 who who WP cord-005453-4057qib7 13369 22 received receive VBD cord-005453-4057qib7 13369 23 ISA ISA NNP cord-005453-4057qib7 13369 24 as as IN cord-005453-4057qib7 13369 25 IFI IFI NNP cord-005453-4057qib7 13369 26 treatment treatment NN cord-005453-4057qib7 13369 27 or or CC cord-005453-4057qib7 13369 28 prophylaxis prophylaxis NN cord-005453-4057qib7 13369 29 . . . cord-005453-4057qib7 13370 1 Due due IN cord-005453-4057qib7 13370 2 to to IN cord-005453-4057qib7 13370 3 the the DT cord-005453-4057qib7 13370 4 lack lack NN cord-005453-4057qib7 13370 5 of of IN cord-005453-4057qib7 13370 6 recommended recommend VBN cord-005453-4057qib7 13370 7 dosing dosing NN cord-005453-4057qib7 13370 8 in in IN cord-005453-4057qib7 13370 9 pediatric pediatric JJ cord-005453-4057qib7 13370 10 patients patient NNS cord-005453-4057qib7 13370 11 and and CC cord-005453-4057qib7 13370 12 a a DT cord-005453-4057qib7 13370 13 clear clear JJ cord-005453-4057qib7 13370 14 target target NN cord-005453-4057qib7 13370 15 ISA ISA NNP cord-005453-4057qib7 13370 16 plasma plasma NN cord-005453-4057qib7 13370 17 trough trough NN cord-005453-4057qib7 13370 18 - - HYPH cord-005453-4057qib7 13370 19 level level NN cord-005453-4057qib7 13370 20 range range NN cord-005453-4057qib7 13370 21 , , , cord-005453-4057qib7 13370 22 the the DT cord-005453-4057qib7 13370 23 therapeutic therapeutic JJ cord-005453-4057qib7 13370 24 monitoring monitoring NN cord-005453-4057qib7 13370 25 ( ( -LRB- cord-005453-4057qib7 13370 26 TDM TDM NNP cord-005453-4057qib7 13370 27 ) ) -RRB- cord-005453-4057qib7 13370 28 of of IN cord-005453-4057qib7 13370 29 ISA ISA NNP cord-005453-4057qib7 13370 30 concentrations concentration NNS cord-005453-4057qib7 13370 31 was be VBD cord-005453-4057qib7 13370 32 applied apply VBN cord-005453-4057qib7 13370 33 by by IN cord-005453-4057qib7 13370 34 a a DT cord-005453-4057qib7 13370 35 validated validate VBN cord-005453-4057qib7 13370 36 liquid liquid JJ cord-005453-4057qib7 13370 37 chromatography chromatography NN cord-005453-4057qib7 13370 38 - - HYPH cord-005453-4057qib7 13370 39 tandem tandem NN cord-005453-4057qib7 13370 40 mass mass NN cord-005453-4057qib7 13370 41 spectrometry spectrometry NN cord-005453-4057qib7 13370 42 ( ( -LRB- cord-005453-4057qib7 13370 43 HLPC HLPC NNP cord-005453-4057qib7 13370 44 - - HYPH cord-005453-4057qib7 13370 45 MS/ MS/ NNP cord-005453-4057qib7 13370 46 MS MS NNP cord-005453-4057qib7 13370 47 ) ) -RRB- cord-005453-4057qib7 13370 48 assay assay NN cord-005453-4057qib7 13370 49 technique technique NN cord-005453-4057qib7 13370 50 . . . cord-005453-4057qib7 13371 1 ISA ISA NNP cord-005453-4057qib7 13371 2 trough trough NN cord-005453-4057qib7 13371 3 plasma plasma NN cord-005453-4057qib7 13371 4 concentrations concentration NNS cord-005453-4057qib7 13371 5 ( ( -LRB- cord-005453-4057qib7 13371 6 C0 C0 NNP cord-005453-4057qib7 13371 7 ) ) -RRB- cord-005453-4057qib7 13371 8 and and CC cord-005453-4057qib7 13371 9 3 3 CD cord-005453-4057qib7 13371 10 hours hour NNS cord-005453-4057qib7 13371 11 after after IN cord-005453-4057qib7 13371 12 drug drug NN cord-005453-4057qib7 13371 13 intake intake NN cord-005453-4057qib7 13371 14 ( ( -LRB- cord-005453-4057qib7 13371 15 C3h c3h NN cord-005453-4057qib7 13371 16 ) ) -RRB- cord-005453-4057qib7 13371 17 were be VBD cord-005453-4057qib7 13371 18 measured measure VBN cord-005453-4057qib7 13371 19 . . . cord-005453-4057qib7 13372 1 Results result NNS cord-005453-4057qib7 13372 2 : : : cord-005453-4057qib7 13373 1 A a DT cord-005453-4057qib7 13373 2 total total NN cord-005453-4057qib7 13373 3 of of IN cord-005453-4057qib7 13373 4 16 16 CD cord-005453-4057qib7 13373 5 allo allo NN cord-005453-4057qib7 13373 6 - - HYPH cord-005453-4057qib7 13373 7 HSCT HSCT NNP cord-005453-4057qib7 13373 8 recipients recipient NNS cord-005453-4057qib7 13373 9 were be VBD cord-005453-4057qib7 13373 10 included include VBN cord-005453-4057qib7 13373 11 , , , cord-005453-4057qib7 13373 12 ( ( -LRB- cord-005453-4057qib7 13373 13 M M NNP cord-005453-4057qib7 13373 14 / / SYM cord-005453-4057qib7 13373 15 F F NNP cord-005453-4057qib7 13373 16 12/4 12/4 CD cord-005453-4057qib7 13373 17 ) ) -RRB- cord-005453-4057qib7 13373 18 ; ; : cord-005453-4057qib7 13373 19 median median JJ cord-005453-4057qib7 13373 20 age age NN cord-005453-4057qib7 13373 21 : : : cord-005453-4057qib7 13373 22 13,1 13,1 CD cord-005453-4057qib7 13373 23 years year NNS cord-005453-4057qib7 13373 24 , , , cord-005453-4057qib7 13373 25 range range VBP cord-005453-4057qib7 13373 26 5 5 CD cord-005453-4057qib7 13373 27 - - SYM cord-005453-4057qib7 13373 28 19 19 CD cord-005453-4057qib7 13373 29 , , , cord-005453-4057qib7 13373 30 median median JJ cord-005453-4057qib7 13373 31 body body NN cord-005453-4057qib7 13373 32 - - HYPH cord-005453-4057qib7 13373 33 weight weight NN cord-005453-4057qib7 13374 1 48,7 48,7 LS cord-005453-4057qib7 13374 2 Kg kg CD cord-005453-4057qib7 13374 3 ( ( -LRB- cord-005453-4057qib7 13374 4 range range VBP cord-005453-4057qib7 13374 5 17 17 CD cord-005453-4057qib7 13374 6 - - SYM cord-005453-4057qib7 13374 7 80 80 CD cord-005453-4057qib7 13374 8 ) ) -RRB- cord-005453-4057qib7 13374 9 . . . cord-005453-4057qib7 13375 1 ISA ISA NNP cord-005453-4057qib7 13375 2 was be VBD cord-005453-4057qib7 13375 3 used use VBN cord-005453-4057qib7 13375 4 as as IN cord-005453-4057qib7 13375 5 IFI IFI NNP cord-005453-4057qib7 13375 6 treatment treatment NN cord-005453-4057qib7 13375 7 in in IN cord-005453-4057qib7 13375 8 14 14 CD cord-005453-4057qib7 13375 9 cases case NNS cord-005453-4057qib7 13375 10 and and CC cord-005453-4057qib7 13375 11 as as IN cord-005453-4057qib7 13375 12 prophylaxis prophylaxis NN cord-005453-4057qib7 13375 13 in in IN cord-005453-4057qib7 13375 14 2 2 CD cord-005453-4057qib7 13375 15 patients patient NNS cord-005453-4057qib7 13375 16 . . . cord-005453-4057qib7 13376 1 Donors donor NNS cord-005453-4057qib7 13376 2 were be VBD cord-005453-4057qib7 13376 3 haploidentical haploidentical JJ cord-005453-4057qib7 13376 4 in in IN cord-005453-4057qib7 13376 5 9 9 CD cord-005453-4057qib7 13376 6 patients patient NNS cord-005453-4057qib7 13376 7 , , , cord-005453-4057qib7 13376 8 matched match VBN cord-005453-4057qib7 13376 9 - - HYPH cord-005453-4057qib7 13376 10 sibling sibling NN cord-005453-4057qib7 13376 11 in in IN cord-005453-4057qib7 13376 12 4 4 CD cord-005453-4057qib7 13376 13 , , , cord-005453-4057qib7 13376 14 allogenic allogenic JJ cord-005453-4057qib7 13376 15 - - HYPH cord-005453-4057qib7 13376 16 unrelated unrelated JJ cord-005453-4057qib7 13376 17 in in IN cord-005453-4057qib7 13376 18 4 4 CD cord-005453-4057qib7 13376 19 cases case NNS cord-005453-4057qib7 13376 20 . . . cord-005453-4057qib7 13377 1 According accord VBG cord-005453-4057qib7 13377 2 to to IN cord-005453-4057qib7 13377 3 EORTC eortc NN cord-005453-4057qib7 13377 4 criteria criterion NNS cord-005453-4057qib7 13377 5 , , , cord-005453-4057qib7 13377 6 IFI IFI NNP cord-005453-4057qib7 13377 7 was be VBD cord-005453-4057qib7 13377 8 proven prove VBN cord-005453-4057qib7 13377 9 in in IN cord-005453-4057qib7 13377 10 3 3 CD cord-005453-4057qib7 13377 11 patients patient NNS cord-005453-4057qib7 13377 12 ( ( -LRB- cord-005453-4057qib7 13377 13 1 1 CD cord-005453-4057qib7 13377 14 Penicilum Penicilum NNP cord-005453-4057qib7 13377 15 , , , cord-005453-4057qib7 13377 16 1 1 CD cord-005453-4057qib7 13377 17 Mucor Mucor NNP cord-005453-4057qib7 13377 18 , , , cord-005453-4057qib7 13377 19 1 1 CD cord-005453-4057qib7 13377 20 Aspergillus aspergillus NN cord-005453-4057qib7 13377 21 fumigatus fumigatus NN cord-005453-4057qib7 13377 22 ) ) -RRB- cord-005453-4057qib7 13377 23 , , , cord-005453-4057qib7 13377 24 probable probable JJ cord-005453-4057qib7 13377 25 in in IN cord-005453-4057qib7 13377 26 5 5 CD cord-005453-4057qib7 13377 27 and and CC cord-005453-4057qib7 13377 28 possible possible JJ cord-005453-4057qib7 13377 29 in in IN cord-005453-4057qib7 13377 30 7 7 CD cord-005453-4057qib7 13377 31 patients patient NNS cord-005453-4057qib7 13377 32 . . . cord-005453-4057qib7 13378 1 Lungs lung NNS cord-005453-4057qib7 13378 2 were be VBD cord-005453-4057qib7 13378 3 the the DT cord-005453-4057qib7 13378 4 main main JJ cord-005453-4057qib7 13378 5 localization localization NN cord-005453-4057qib7 13378 6 ( ( -LRB- cord-005453-4057qib7 13378 7 12 12 CD cord-005453-4057qib7 13378 8 cases case NNS cord-005453-4057qib7 13378 9 ) ) -RRB- cord-005453-4057qib7 13378 10 , , , cord-005453-4057qib7 13378 11 associated associate VBN cord-005453-4057qib7 13378 12 with with IN cord-005453-4057qib7 13378 13 CNS CNS NNP cord-005453-4057qib7 13378 14 involvement involvement NN cord-005453-4057qib7 13378 15 in in IN cord-005453-4057qib7 13378 16 4 4 CD cord-005453-4057qib7 13378 17 cases case NNS cord-005453-4057qib7 13378 18 and and CC cord-005453-4057qib7 13378 19 paranasal paranasal NN cord-005453-4057qib7 13378 20 sinuses sinus NNS cord-005453-4057qib7 13378 21 in in IN cord-005453-4057qib7 13378 22 3 3 CD cord-005453-4057qib7 13378 23 ; ; SYM cord-005453-4057qib7 13378 24 1 1 CD cord-005453-4057qib7 13378 25 patient patient NN cord-005453-4057qib7 13378 26 had have VBD cord-005453-4057qib7 13378 27 possible possible JJ cord-005453-4057qib7 13378 28 hepatic hepatic JJ cord-005453-4057qib7 13378 29 candidiasis candidiasis NN cord-005453-4057qib7 13378 30 . . . cord-005453-4057qib7 13379 1 All all DT cord-005453-4057qib7 13379 2 patients patient NNS cord-005453-4057qib7 13379 3 , , , cord-005453-4057qib7 13379 4 but but CC cord-005453-4057qib7 13379 5 one one CD cord-005453-4057qib7 13379 6 , , , cord-005453-4057qib7 13379 7 received receive VBD cord-005453-4057qib7 13379 8 ISA ISA NNP cord-005453-4057qib7 13379 9 as as IN cord-005453-4057qib7 13379 10 rescue rescue NN cord-005453-4057qib7 13379 11 treatment treatment NN cord-005453-4057qib7 13379 12 for for IN cord-005453-4057qib7 13379 13 previous previous JJ cord-005453-4057qib7 13379 14 therapeutic therapeutic JJ cord-005453-4057qib7 13379 15 failure failure NN cord-005453-4057qib7 13379 16 ( ( -LRB- cord-005453-4057qib7 13379 17 6 6 CD cord-005453-4057qib7 13379 18 AmBisome AmBisome NNP cord-005453-4057qib7 13379 19 , , , cord-005453-4057qib7 13379 20 3 3 CD cord-005453-4057qib7 13379 21 Voriconazole Voriconazole NNP cord-005453-4057qib7 13379 22 , , , cord-005453-4057qib7 13379 23 1 1 CD cord-005453-4057qib7 13379 24 combination combination NN cord-005453-4057qib7 13379 25 therapy therapy NN cord-005453-4057qib7 13379 26 , , , cord-005453-4057qib7 13379 27 1 1 CD cord-005453-4057qib7 13379 28 Posaconazole Posaconazole NNP cord-005453-4057qib7 13379 29 ) ) -RRB- cord-005453-4057qib7 13379 30 . . . cord-005453-4057qib7 13380 1 Seven seven CD cord-005453-4057qib7 13380 2 patients patient NNS cord-005453-4057qib7 13380 3 received receive VBD cord-005453-4057qib7 13380 4 only only RB cord-005453-4057qib7 13380 5 IV IV NNP cord-005453-4057qib7 13380 6 ISA ISA NNP cord-005453-4057qib7 13380 7 , , , cord-005453-4057qib7 13380 8 3 3 CD cord-005453-4057qib7 13380 9 received receive VBD cord-005453-4057qib7 13380 10 only only RB cord-005453-4057qib7 13380 11 oral oral JJ cord-005453-4057qib7 13380 12 ISA ISA NNP cord-005453-4057qib7 13380 13 whereas whereas IN cord-005453-4057qib7 13380 14 6 6 CD cord-005453-4057qib7 13380 15 patients patient NNS cord-005453-4057qib7 13380 16 received receive VBD cord-005453-4057qib7 13380 17 both both CC cord-005453-4057qib7 13380 18 IV IV NNP cord-005453-4057qib7 13380 19 and and CC cord-005453-4057qib7 13380 20 oral oral JJ cord-005453-4057qib7 13380 21 ISA ISA NNP cord-005453-4057qib7 13380 22 . . . cord-005453-4057qib7 13381 1 Patients patient NNS cord-005453-4057qib7 13381 2 under under IN cord-005453-4057qib7 13381 3 20 20 CD cord-005453-4057qib7 13381 4 Kg Kg NNP cord-005453-4057qib7 13381 5 body body NN cord-005453-4057qib7 13381 6 weight weight NN cord-005453-4057qib7 13381 7 received receive VBD cord-005453-4057qib7 13381 8 half half DT cord-005453-4057qib7 13381 9 ISA ISA NNP cord-005453-4057qib7 13381 10 dose dose NN cord-005453-4057qib7 13381 11 ( ( -LRB- cord-005453-4057qib7 13381 12 100 100 CD cord-005453-4057qib7 13381 13 mg mg NN cord-005453-4057qib7 13381 14 TID TID NNP cord-005453-4057qib7 13381 15 loading loading NN cord-005453-4057qib7 13381 16 dose dose NN cord-005453-4057qib7 13381 17 on on IN cord-005453-4057qib7 13381 18 days day NNS cord-005453-4057qib7 13381 19 1 1 CD cord-005453-4057qib7 13381 20 and and CC cord-005453-4057qib7 13381 21 2 2 CD cord-005453-4057qib7 13381 22 , , , cord-005453-4057qib7 13381 23 100 100 CD cord-005453-4057qib7 13381 24 mg mg NNP cord-005453-4057qib7 13381 25 / / SYM cord-005453-4057qib7 13381 26 die die NNP cord-005453-4057qib7 13381 27 manteinance manteinance NNP cord-005453-4057qib7 13381 28 ) ) -RRB- cord-005453-4057qib7 13381 29 . . . cord-005453-4057qib7 13382 1 The the DT cord-005453-4057qib7 13382 2 others other NNS cord-005453-4057qib7 13382 3 received receive VBD cord-005453-4057qib7 13382 4 adult adult NN cord-005453-4057qib7 13382 5 schedule schedule NN cord-005453-4057qib7 13382 6 ; ; : cord-005453-4057qib7 13382 7 only only RB cord-005453-4057qib7 13382 8 5 5 CD cord-005453-4057qib7 13382 9 patients patient NNS cord-005453-4057qib7 13382 10 received receive VBD cord-005453-4057qib7 13382 11 loading loading NN cord-005453-4057qib7 13382 12 dose dose NN cord-005453-4057qib7 13382 13 . . . cord-005453-4057qib7 13383 1 ISA ISA NNP cord-005453-4057qib7 13383 2 was be VBD cord-005453-4057qib7 13383 3 administered administer VBN cord-005453-4057qib7 13383 4 for for IN cord-005453-4057qib7 13383 5 a a DT cord-005453-4057qib7 13383 6 median median NN cord-005453-4057qib7 13383 7 of of IN cord-005453-4057qib7 13383 8 83 83 CD cord-005453-4057qib7 13383 9 days day NNS cord-005453-4057qib7 13383 10 ( ( -LRB- cord-005453-4057qib7 13383 11 range range NN cord-005453-4057qib7 13383 12 : : : cord-005453-4057qib7 13383 13 24 24 CD cord-005453-4057qib7 13383 14 - - SYM cord-005453-4057qib7 13383 15 240 240 CD cord-005453-4057qib7 13383 16 ) ) -RRB- cord-005453-4057qib7 13383 17 . . . cord-005453-4057qib7 13384 1 In in IN cord-005453-4057qib7 13384 2 3 3 CD cord-005453-4057qib7 13384 3 patients patient NNS cord-005453-4057qib7 13384 4 ISA ISA NNP cord-005453-4057qib7 13384 5 was be VBD cord-005453-4057qib7 13384 6 administered administer VBN cord-005453-4057qib7 13384 7 in in IN cord-005453-4057qib7 13384 8 combination combination NN cord-005453-4057qib7 13384 9 with with IN cord-005453-4057qib7 13384 10 Caspofungin Caspofungin NNP cord-005453-4057qib7 13384 11 . . . cord-005453-4057qib7 13385 1 TDM TDM NNP cord-005453-4057qib7 13385 2 was be VBD cord-005453-4057qib7 13385 3 applied apply VBN cord-005453-4057qib7 13385 4 to to IN cord-005453-4057qib7 13385 5 5 5 CD cord-005453-4057qib7 13385 6 patients patient NNS cord-005453-4057qib7 13385 7 including include VBG cord-005453-4057qib7 13385 8 1 1 CD cord-005453-4057qib7 13385 9 patient patient NN cord-005453-4057qib7 13385 10 with with IN cord-005453-4057qib7 13385 11 severe severe JJ cord-005453-4057qib7 13385 12 VOD vod NN cord-005453-4057qib7 13385 13 and and CC cord-005453-4057qib7 13385 14 1 1 CD cord-005453-4057qib7 13385 15 with with IN cord-005453-4057qib7 13385 16 renal renal JJ cord-005453-4057qib7 13385 17 failure failure NN cord-005453-4057qib7 13385 18 secondary secondary JJ cord-005453-4057qib7 13385 19 to to IN cord-005453-4057qib7 13385 20 TA TA NNP cord-005453-4057qib7 13385 21 - - HYPH cord-005453-4057qib7 13385 22 TMA TMA NNP cord-005453-4057qib7 13385 23 . . . cord-005453-4057qib7 13386 1 The the DT cord-005453-4057qib7 13386 2 median median JJ cord-005453-4057qib7 13386 3 ISA ISA NNP cord-005453-4057qib7 13386 4 concentrations concentration NNS cord-005453-4057qib7 13386 5 were be VBD cord-005453-4057qib7 13386 6 3.94 3.94 CD cord-005453-4057qib7 13386 7 ( ( -LRB- cord-005453-4057qib7 13386 8 1.57 1.57 CD cord-005453-4057qib7 13386 9 - - SYM cord-005453-4057qib7 13386 10 5.85 5.85 CD cord-005453-4057qib7 13386 11 ) ) -RRB- cord-005453-4057qib7 13387 1 mg mg NNP cord-005453-4057qib7 13387 2 / / SYM cord-005453-4057qib7 13387 3 L L NNP cord-005453-4057qib7 13387 4 and and CC cord-005453-4057qib7 13387 5 4.7 4.7 CD cord-005453-4057qib7 13387 6 ( ( -LRB- cord-005453-4057qib7 13387 7 1.29 1.29 CD cord-005453-4057qib7 13387 8 - - SYM cord-005453-4057qib7 13387 9 8.37 8.37 CD cord-005453-4057qib7 13387 10 ) ) -RRB- cord-005453-4057qib7 13388 1 mg mg NNP cord-005453-4057qib7 13388 2 / / SYM cord-005453-4057qib7 13388 3 L L NNP cord-005453-4057qib7 13388 4 for for IN cord-005453-4057qib7 13388 5 C0 c0 NN cord-005453-4057qib7 13388 6 and and CC cord-005453-4057qib7 13388 7 C3h C3h NNP cord-005453-4057qib7 13388 8 , , , cord-005453-4057qib7 13388 9 respectively respectively RB cord-005453-4057qib7 13388 10 . . . cord-005453-4057qib7 13389 1 IFI IFI NNP cord-005453-4057qib7 13389 2 complete complete JJ cord-005453-4057qib7 13389 3 remission remission NN cord-005453-4057qib7 13389 4 was be VBD cord-005453-4057qib7 13389 5 achieved achieve VBN cord-005453-4057qib7 13389 6 in in IN cord-005453-4057qib7 13389 7 5 5 CD cord-005453-4057qib7 13389 8 cases case NNS cord-005453-4057qib7 13389 9 , , , cord-005453-4057qib7 13389 10 partial partial JJ cord-005453-4057qib7 13389 11 remission remission NN cord-005453-4057qib7 13389 12 in in IN cord-005453-4057qib7 13389 13 3 3 CD cord-005453-4057qib7 13389 14 ; ; : cord-005453-4057qib7 13389 15 treatment treatment NN cord-005453-4057qib7 13389 16 failure failure NN cord-005453-4057qib7 13389 17 was be VBD cord-005453-4057qib7 13389 18 experienced experience VBN cord-005453-4057qib7 13389 19 by by IN cord-005453-4057qib7 13389 20 2 2 CD cord-005453-4057qib7 13389 21 patients patient NNS cord-005453-4057qib7 13389 22 . . . cord-005453-4057qib7 13390 1 In in IN cord-005453-4057qib7 13390 2 3 3 CD cord-005453-4057qib7 13390 3 cases case NNS cord-005453-4057qib7 13390 4 fungal fungal JJ cord-005453-4057qib7 13390 5 lesions lesion NNS cord-005453-4057qib7 13390 6 remained remain VBD cord-005453-4057qib7 13390 7 stable stable JJ cord-005453-4057qib7 13390 8 . . . cord-005453-4057qib7 13391 1 CTAE CTAE NNP cord-005453-4057qib7 13391 2 grade grade NN cord-005453-4057qib7 13391 3 II II NNP cord-005453-4057qib7 13391 4 - - HYPH cord-005453-4057qib7 13391 5 III iii CD cord-005453-4057qib7 13391 6 toxicity toxicity NN cord-005453-4057qib7 13391 7 was be VBD cord-005453-4057qib7 13391 8 observed observe VBN cord-005453-4057qib7 13391 9 during during IN cord-005453-4057qib7 13391 10 treatment treatment NN cord-005453-4057qib7 13391 11 in in IN cord-005453-4057qib7 13391 12 3 3 CD cord-005453-4057qib7 13391 13 patients patient NNS cord-005453-4057qib7 13391 14 , , , cord-005453-4057qib7 13391 15 with with IN cord-005453-4057qib7 13391 16 increased increase VBN cord-005453-4057qib7 13391 17 transaminase transaminase NN cord-005453-4057qib7 13391 18 and/or and/or CC cord-005453-4057qib7 13391 19 creatinine creatinine NN cord-005453-4057qib7 13391 20 levels level NNS cord-005453-4057qib7 13391 21 which which WDT cord-005453-4057qib7 13391 22 resolved resolve VBD cord-005453-4057qib7 13391 23 after after IN cord-005453-4057qib7 13391 24 temporary temporary JJ cord-005453-4057qib7 13391 25 ISA ISA NNP cord-005453-4057qib7 13391 26 withdrawal withdrawal NN cord-005453-4057qib7 13391 27 . . . cord-005453-4057qib7 13392 1 No no DT cord-005453-4057qib7 13392 2 drug drug NN cord-005453-4057qib7 13392 3 - - HYPH cord-005453-4057qib7 13392 4 drug drug NN cord-005453-4057qib7 13392 5 interactions interaction NNS cord-005453-4057qib7 13392 6 were be VBD cord-005453-4057qib7 13392 7 observed observe VBN cord-005453-4057qib7 13392 8 in in IN cord-005453-4057qib7 13392 9 3 3 CD cord-005453-4057qib7 13392 10 patients patient NNS cord-005453-4057qib7 13392 11 receiving receive VBG cord-005453-4057qib7 13392 12 CSA CSA NNP cord-005453-4057qib7 13392 13 as as IN cord-005453-4057qib7 13392 14 GvHD GvHD NNP cord-005453-4057qib7 13392 15 prophylaxis prophylaxis NN cord-005453-4057qib7 13392 16 and and CC cord-005453-4057qib7 13392 17 no no DT cord-005453-4057qib7 13392 18 modification modification NN cord-005453-4057qib7 13392 19 of of IN cord-005453-4057qib7 13392 20 CSA CSA NNP cord-005453-4057qib7 13392 21 daily daily RB cord-005453-4057qib7 13392 22 dose dose NN cord-005453-4057qib7 13392 23 was be VBD cord-005453-4057qib7 13392 24 needed need VBN cord-005453-4057qib7 13392 25 . . . cord-005453-4057qib7 13393 1 Conclusions conclusion NNS cord-005453-4057qib7 13393 2 : : : cord-005453-4057qib7 13394 1 Isavuconazole Isavuconazole NNP cord-005453-4057qib7 13394 2 use use NN cord-005453-4057qib7 13394 3 may may MD cord-005453-4057qib7 13394 4 be be VB cord-005453-4057qib7 13394 5 considered consider VBN cord-005453-4057qib7 13394 6 in in IN cord-005453-4057qib7 13394 7 the the DT cord-005453-4057qib7 13394 8 pediatric pediatric JJ cord-005453-4057qib7 13394 9 population population NN cord-005453-4057qib7 13394 10 , , , cord-005453-4057qib7 13394 11 even even RB cord-005453-4057qib7 13394 12 in in IN cord-005453-4057qib7 13394 13 the the DT cord-005453-4057qib7 13394 14 HSCT HSCT NNP cord-005453-4057qib7 13394 15 setting setting NN cord-005453-4057qib7 13394 16 , , , cord-005453-4057qib7 13394 17 for for IN cord-005453-4057qib7 13394 18 its -PRON- PRP$ cord-005453-4057qib7 13394 19 safety safety NN cord-005453-4057qib7 13394 20 , , , cord-005453-4057qib7 13394 21 efficacy efficacy NN cord-005453-4057qib7 13394 22 , , , cord-005453-4057qib7 13394 23 tolerability tolerability NN cord-005453-4057qib7 13394 24 , , , cord-005453-4057qib7 13394 25 no no DT cord-005453-4057qib7 13394 26 drug drug NN cord-005453-4057qib7 13394 27 - - HYPH cord-005453-4057qib7 13394 28 drug drug NN cord-005453-4057qib7 13394 29 interaction interaction NN cord-005453-4057qib7 13394 30 . . . cord-005453-4057qib7 13395 1 Of of RB cord-005453-4057qib7 13395 2 course course RB cord-005453-4057qib7 13395 3 these these DT cord-005453-4057qib7 13395 4 data datum NNS cord-005453-4057qib7 13395 5 deserve deserve VBP cord-005453-4057qib7 13395 6 further further JJ cord-005453-4057qib7 13395 7 evaluation evaluation NN cord-005453-4057qib7 13395 8 . . . cord-005453-4057qib7 13396 1 Disclosure disclosure NN cord-005453-4057qib7 13396 2 : : : cord-005453-4057qib7 13396 3 Nothing nothing NN cord-005453-4057qib7 13396 4 to to TO cord-005453-4057qib7 13396 5 declare declare VB cord-005453-4057qib7 13396 6 P608 P608 NNP cord-005453-4057qib7 13396 7 New New NNP cord-005453-4057qib7 13396 8 treosulfan treosulfan NN cord-005453-4057qib7 13396 9 - - HYPH cord-005453-4057qib7 13396 10 based base VBN cord-005453-4057qib7 13396 11 conditioning conditioning NN cord-005453-4057qib7 13396 12 regimens regimen NNS cord-005453-4057qib7 13396 13 including include VBG cord-005453-4057qib7 13396 14 epigenetic epigenetic JJ cord-005453-4057qib7 13396 15 agents agent NNS cord-005453-4057qib7 13396 16 in in IN cord-005453-4057qib7 13396 17 patients patient NNS cord-005453-4057qib7 13396 18 with with IN cord-005453-4057qib7 13396 19 very very RB cord-005453-4057qib7 13396 20 high high JJ cord-005453-4057qib7 13396 21 - - HYPH cord-005453-4057qib7 13396 22 risk risk NN cord-005453-4057qib7 13396 23 neuroblastoma neuroblastoma NN cord-005453-4057qib7 13396 24 Background background NN cord-005453-4057qib7 13396 25 : : : cord-005453-4057qib7 13397 1 The the DT cord-005453-4057qib7 13397 2 pts pts NN cord-005453-4057qib7 13397 3 aged age VBN cord-005453-4057qib7 13397 4 18 18 CD cord-005453-4057qib7 13397 5 mos mos NNP cord-005453-4057qib7 13397 6 . . NNP cord-005453-4057qib7 13397 7 or or CC cord-005453-4057qib7 13397 8 older old JJR cord-005453-4057qib7 13397 9 with with IN cord-005453-4057qib7 13397 10 disseminated disseminate VBN cord-005453-4057qib7 13397 11 NB NB NNP cord-005453-4057qib7 13397 12 involving involve VBG cord-005453-4057qib7 13397 13 bone bone NN cord-005453-4057qib7 13397 14 and and CC cord-005453-4057qib7 13397 15 bone bone NN cord-005453-4057qib7 13397 16 marrow marrow NN cord-005453-4057qib7 13397 17 constitute constitute VBP cord-005453-4057qib7 13397 18 a a DT cord-005453-4057qib7 13397 19 group group NN cord-005453-4057qib7 13397 20 of of IN cord-005453-4057qib7 13397 21 pts pts NN cord-005453-4057qib7 13397 22 with with IN cord-005453-4057qib7 13397 23 very very RB cord-005453-4057qib7 13397 24 poor poor JJ cord-005453-4057qib7 13397 25 prognosis prognosis NN cord-005453-4057qib7 13397 26 . . . cord-005453-4057qib7 13398 1 Although although IN cord-005453-4057qib7 13398 2 the the DT cord-005453-4057qib7 13398 3 majority majority NN cord-005453-4057qib7 13398 4 of of IN cord-005453-4057qib7 13398 5 them -PRON- PRP cord-005453-4057qib7 13398 6 are be VBP cord-005453-4057qib7 13398 7 responsive responsive JJ cord-005453-4057qib7 13398 8 to to TO cord-005453-4057qib7 13398 9 intensive intensive JJ cord-005453-4057qib7 13398 10 conventional conventional JJ cord-005453-4057qib7 13398 11 chemotherapy chemotherapy NN cord-005453-4057qib7 13398 12 , , , cord-005453-4057qib7 13398 13 most most RBS cord-005453-4057qib7 13398 14 eventually eventually RB cord-005453-4057qib7 13398 15 relapse relapse VBP cord-005453-4057qib7 13398 16 with with IN cord-005453-4057qib7 13398 17 EFS EFS NNP cord-005453-4057qib7 13398 18 at at IN cord-005453-4057qib7 13398 19 5 5 CD cord-005453-4057qib7 13398 20 years year NNS cord-005453-4057qib7 13398 21 of of IN cord-005453-4057qib7 13398 22 < < NNP cord-005453-4057qib7 13398 23 10 10 CD cord-005453-4057qib7 13398 24 % % NN cord-005453-4057qib7 13398 25 . . . cord-005453-4057qib7 13399 1 At at IN cord-005453-4057qib7 13399 2 the the DT cord-005453-4057qib7 13399 3 beginning beginning NN cord-005453-4057qib7 13399 4 of of IN cord-005453-4057qib7 13399 5 the the DT cord-005453-4057qib7 13399 6 year year NN cord-005453-4057qib7 13399 7 2018 2018 CD cord-005453-4057qib7 13399 8 we -PRON- PRP cord-005453-4057qib7 13399 9 came come VBD cord-005453-4057qib7 13399 10 up up RP cord-005453-4057qib7 13399 11 with with IN cord-005453-4057qib7 13399 12 a a DT cord-005453-4057qib7 13399 13 protocol protocol NN cord-005453-4057qib7 13399 14 for for IN cord-005453-4057qib7 13399 15 this this DT cord-005453-4057qib7 13399 16 very very RB cord-005453-4057qib7 13399 17 unfavorable unfavorable JJ cord-005453-4057qib7 13399 18 group group NN cord-005453-4057qib7 13399 19 including include VBG cord-005453-4057qib7 13399 20 epigenetic epigenetic JJ cord-005453-4057qib7 13399 21 therapy therapy NN cord-005453-4057qib7 13399 22 ( ( -LRB- cord-005453-4057qib7 13399 23 5-azacitidine 5-azacitidine CD cord-005453-4057qib7 13399 24 ) ) -RRB- cord-005453-4057qib7 13399 25 in in IN cord-005453-4057qib7 13399 26 the the DT cord-005453-4057qib7 13399 27 phases phase NNS cord-005453-4057qib7 13399 28 of of IN cord-005453-4057qib7 13399 29 consolidation consolidation NN cord-005453-4057qib7 13399 30 . . . cord-005453-4057qib7 13400 1 Methods method NNS cord-005453-4057qib7 13400 2 : : : cord-005453-4057qib7 13401 1 Seven seven CD cord-005453-4057qib7 13401 2 pts pt NNS cord-005453-4057qib7 13401 3 with with IN cord-005453-4057qib7 13401 4 a a DT cord-005453-4057qib7 13401 5 median median JJ cord-005453-4057qib7 13401 6 age age NN cord-005453-4057qib7 13401 7 of of IN cord-005453-4057qib7 13401 8 4 4 CD cord-005453-4057qib7 13401 9 ( ( -LRB- cord-005453-4057qib7 13401 10 2,6 2,6 CD cord-005453-4057qib7 13401 11 - - SYM cord-005453-4057qib7 13401 12 8 8 CD cord-005453-4057qib7 13401 13 ) ) -RRB- cord-005453-4057qib7 13401 14 years year NNS cord-005453-4057qib7 13401 15 completed complete VBD cord-005453-4057qib7 13401 16 the the DT cord-005453-4057qib7 13401 17 protocol protocol NN cord-005453-4057qib7 13401 18 and and CC cord-005453-4057qib7 13401 19 received receive VBD cord-005453-4057qib7 13401 20 HDCT HDCT NNP cord-005453-4057qib7 13401 21 with with IN cord-005453-4057qib7 13401 22 autologous autologous JJ cord-005453-4057qib7 13401 23 SCT SCT NNP cord-005453-4057qib7 13401 24 as as IN cord-005453-4057qib7 13401 25 a a DT cord-005453-4057qib7 13401 26 consolidation consolidation NN cord-005453-4057qib7 13401 27 . . . cord-005453-4057qib7 13402 1 HDCT HDCT NNP cord-005453-4057qib7 13402 2 included include VBD cord-005453-4057qib7 13402 3 two two CD cord-005453-4057qib7 13402 4 different different JJ cord-005453-4057qib7 13402 5 epigenetic epigenetic JJ cord-005453-4057qib7 13402 6 agent agent NN cord-005453-4057qib7 13402 7 containing contain VBG cord-005453-4057qib7 13402 8 regimes regime NNS cord-005453-4057qib7 13402 9 according accord VBG cord-005453-4057qib7 13402 10 to to IN cord-005453-4057qib7 13402 11 tumor tumor NN cord-005453-4057qib7 13402 12 response response NN cord-005453-4057qib7 13402 13 to to IN cord-005453-4057qib7 13402 14 the the DT cord-005453-4057qib7 13402 15 induction induction NN cord-005453-4057qib7 13402 16 therapy therapy NN cord-005453-4057qib7 13402 17 assessed assess VBN cord-005453-4057qib7 13402 18 by by IN cord-005453-4057qib7 13402 19 123 123 CD cord-005453-4057qib7 13402 20 I I NNP cord-005453-4057qib7 13402 21 - - HYPH cord-005453-4057qib7 13402 22 MIBG MIBG NNP cord-005453-4057qib7 13402 23 and and CC cord-005453-4057qib7 13402 24 MRI MRI NNP cord-005453-4057qib7 13402 25 ( ( -LRB- cord-005453-4057qib7 13402 26 CT CT NNP cord-005453-4057qib7 13402 27 - - HYPH cord-005453-4057qib7 13402 28 scan scan NNP cord-005453-4057qib7 13402 29 ) ) -RRB- cord-005453-4057qib7 13402 30 . . . cord-005453-4057qib7 13403 1 Three three CD cord-005453-4057qib7 13403 2 pts pt NNS cord-005453-4057qib7 13403 3 revealing reveal VBG cord-005453-4057qib7 13403 4 large large JJ cord-005453-4057qib7 13403 5 active active JJ cord-005453-4057qib7 13403 6 residual residual JJ cord-005453-4057qib7 13403 7 tumor tumor NN cord-005453-4057qib7 13403 8 assessed assess VBN cord-005453-4057qib7 13403 9 by by IN cord-005453-4057qib7 13403 10 123 123 CD cord-005453-4057qib7 13403 11 I I NNP cord-005453-4057qib7 13403 12 - - HYPH cord-005453-4057qib7 13403 13 MIBG MIBG NNP cord-005453-4057qib7 13403 14 scan scan NN cord-005453-4057qib7 13403 15 or or CC cord-005453-4057qib7 13403 16 multiple multiple JJ cord-005453-4057qib7 13403 17 active active JJ cord-005453-4057qib7 13403 18 bone bone NN cord-005453-4057qib7 13403 19 metastases metastasis NNS cord-005453-4057qib7 13403 20 received receive VBD cord-005453-4057qib7 13403 21 a a DT cord-005453-4057qib7 13403 22 conditioning conditioning NN cord-005453-4057qib7 13403 23 regimen regimen NN cord-005453-4057qib7 13403 24 ( ( -LRB- cord-005453-4057qib7 13403 25 regimen regimen NN cord-005453-4057qib7 13403 26 A a NN cord-005453-4057qib7 13403 27 ) ) -RRB- cord-005453-4057qib7 13403 28 including include VBG cord-005453-4057qib7 13403 29 131 131 CD cord-005453-4057qib7 13403 30 I I NNP cord-005453-4057qib7 13403 31 - - HYPH cord-005453-4057qib7 13403 32 MIBG MIBG NNP cord-005453-4057qib7 13403 33 therapy therapy NN cord-005453-4057qib7 13403 34 at at IN cord-005453-4057qib7 13403 35 a a DT cord-005453-4057qib7 13403 36 dose dose NN cord-005453-4057qib7 13403 37 4.0 4.0 CD cord-005453-4057qib7 13403 38 - - SYM cord-005453-4057qib7 13403 39 4.4 4.4 CD cord-005453-4057qib7 13403 40 MBe MBe NNS cord-005453-4057qib7 13403 41 / / SYM cord-005453-4057qib7 13403 42 kg kg NNS cord-005453-4057qib7 13403 43 on on IN cord-005453-4057qib7 13403 44 d-14 d-14 NNP cord-005453-4057qib7 13403 45 , , , cord-005453-4057qib7 13403 46 Treosulfan Treosulfan NNP cord-005453-4057qib7 13403 47 10000 10000 CD cord-005453-4057qib7 13403 48 mg mg NNP cord-005453-4057qib7 13403 49 / / SYM cord-005453-4057qib7 13403 50 m m NN cord-005453-4057qib7 13403 51 2 2 CD cord-005453-4057qib7 13403 52 /d /d NNP cord-005453-4057qib7 13403 53 , , , cord-005453-4057qib7 13403 54 on on IN cord-005453-4057qib7 13403 55 d-6,-5 d-6,-5 NNP cord-005453-4057qib7 13404 1 and and CC cord-005453-4057qib7 13404 2 -4 -4 NNP cord-005453-4057qib7 13404 3 ( ( -LRB- cord-005453-4057qib7 13404 4 total total JJ cord-005453-4057qib7 13404 5 30000 30000 CD cord-005453-4057qib7 13404 6 mg mg NNP cord-005453-4057qib7 13404 7 / / SYM cord-005453-4057qib7 13404 8 m m NNP cord-005453-4057qib7 13404 9 2 2 CD cord-005453-4057qib7 13404 10 ) ) -RRB- cord-005453-4057qib7 13404 11 , , , cord-005453-4057qib7 13404 12 Melphalan Melphalan NNP cord-005453-4057qib7 13404 13 70 70 CD cord-005453-4057qib7 13404 14 mg mg NN cord-005453-4057qib7 13405 1 /m /m NNP cord-005453-4057qib7 13405 2 2 2 CD cord-005453-4057qib7 13406 1 /d /d NNP cord-005453-4057qib7 13406 2 , , , cord-005453-4057qib7 13406 3 on on IN cord-005453-4057qib7 13406 4 d-3,-2 d-3,-2 NNP cord-005453-4057qib7 13406 5 ( ( -LRB- cord-005453-4057qib7 13406 6 total total JJ cord-005453-4057qib7 13406 7 140 140 CD cord-005453-4057qib7 13406 8 mg mg NNP cord-005453-4057qib7 13406 9 / / SYM cord-005453-4057qib7 13406 10 m m NNP cord-005453-4057qib7 13406 11 2 2 CD cord-005453-4057qib7 13406 12 ) ) -RRB- cord-005453-4057qib7 13406 13 , , , cord-005453-4057qib7 13406 14 5-azacitidine 5-azacitidine CD cord-005453-4057qib7 13406 15 75 75 CD cord-005453-4057qib7 13407 1 mg mg NNP cord-005453-4057qib7 13408 1 /m /m NNP cord-005453-4057qib7 13408 2 2 2 CD cord-005453-4057qib7 13408 3 /d /d NNP cord-005453-4057qib7 13408 4 on on IN cord-005453-4057qib7 13408 5 d-9 d-9 NN cord-005453-4057qib7 13408 6 to to IN cord-005453-4057qib7 13409 1 d-5 d-5 NNP cord-005453-4057qib7 13409 2 ( ( -LRB- cord-005453-4057qib7 13409 3 total total JJ cord-005453-4057qib7 13409 4 375 375 CD cord-005453-4057qib7 13409 5 mg mg NNP cord-005453-4057qib7 13409 6 / / SYM cord-005453-4057qib7 13409 7 m m NNP cord-005453-4057qib7 13409 8 2 2 CD cord-005453-4057qib7 13409 9 ) ) -RRB- cord-005453-4057qib7 13409 10 . . . cord-005453-4057qib7 13410 1 Four four CD cord-005453-4057qib7 13410 2 pts pts NN cord-005453-4057qib7 13410 3 with with IN cord-005453-4057qib7 13410 4 CR CR NNP cord-005453-4057qib7 13410 5 or or CC cord-005453-4057qib7 13410 6 VGPR VGPR NNP cord-005453-4057qib7 13410 7 received receive VBD cord-005453-4057qib7 13410 8 a a DT cord-005453-4057qib7 13410 9 « « `` cord-005453-4057qib7 13410 10 split split NN cord-005453-4057qib7 13410 11 » » '' cord-005453-4057qib7 13410 12 conditioning conditioning NN cord-005453-4057qib7 13410 13 regimen regimen NN cord-005453-4057qib7 13410 14 ( ( -LRB- cord-005453-4057qib7 13410 15 regimen regimen NN cord-005453-4057qib7 13410 16 B B NNP cord-005453-4057qib7 13410 17 ) ) -RRB- cord-005453-4057qib7 13410 18 including include VBG cord-005453-4057qib7 13410 19 Treosulfan Treosulfan NNP cord-005453-4057qib7 13410 20 10000 10000 CD cord-005453-4057qib7 13410 21 mg mg NNP cord-005453-4057qib7 13410 22 / / SYM cord-005453-4057qib7 13410 23 m m NN cord-005453-4057qib7 13411 1 2 2 LS cord-005453-4057qib7 13411 2 /d /d NNP cord-005453-4057qib7 13411 3 , , , cord-005453-4057qib7 13411 4 on on IN cord-005453-4057qib7 13411 5 d d NNP cord-005453-4057qib7 13411 6 11 11 CD cord-005453-4057qib7 13411 7 and and CC cord-005453-4057qib7 13411 8 -10 -10 NN cord-005453-4057qib7 13411 9 , , , cord-005453-4057qib7 13411 10 and and CC cord-005453-4057qib7 13411 11 on on IN cord-005453-4057qib7 13411 12 d-4 d-4 NN cord-005453-4057qib7 13411 13 and and CC cord-005453-4057qib7 13411 14 d-3 d-3 NNP cord-005453-4057qib7 13411 15 ( ( -LRB- cord-005453-4057qib7 13411 16 total total JJ cord-005453-4057qib7 13411 17 40000 40000 CD cord-005453-4057qib7 13411 18 mg mg NNP cord-005453-4057qib7 13411 19 / / SYM cord-005453-4057qib7 13411 20 m m NNP cord-005453-4057qib7 13411 21 2 2 CD cord-005453-4057qib7 13411 22 ) ) -RRB- cord-005453-4057qib7 13411 23 , , , cord-005453-4057qib7 13411 24 Melphalan Melphalan NNP cord-005453-4057qib7 13411 25 70 70 CD cord-005453-4057qib7 13412 1 mg mg NNP cord-005453-4057qib7 13413 1 /m /m NNP cord-005453-4057qib7 13413 2 2 2 CD cord-005453-4057qib7 13413 3 /d /d NNP cord-005453-4057qib7 13413 4 , , , cord-005453-4057qib7 13413 5 on on IN cord-005453-4057qib7 13413 6 d-3 d-3 NN cord-005453-4057qib7 13413 7 and and CC cord-005453-4057qib7 13413 8 -2 -2 NNP cord-005453-4057qib7 13413 9 ( ( -LRB- cord-005453-4057qib7 13413 10 total total JJ cord-005453-4057qib7 13413 11 140 140 CD cord-005453-4057qib7 13413 12 mg mg NNP cord-005453-4057qib7 13413 13 / / SYM cord-005453-4057qib7 13413 14 m m NNP cord-005453-4057qib7 13413 15 2 2 CD cord-005453-4057qib7 13413 16 ) ) -RRB- cord-005453-4057qib7 13413 17 , , , cord-005453-4057qib7 13413 18 and and CC cord-005453-4057qib7 13413 19 5-azacitidine 5-azacitidine CD cord-005453-4057qib7 13413 20 75 75 CD cord-005453-4057qib7 13414 1 mg mg NNP cord-005453-4057qib7 13414 2 / / SYM cord-005453-4057qib7 13414 3 m m NN cord-005453-4057qib7 13414 4 2 2 CD cord-005453-4057qib7 13415 1 /d /d NNP cord-005453-4057qib7 13415 2 , , , cord-005453-4057qib7 13415 3 on on IN cord-005453-4057qib7 13415 4 d d XX cord-005453-4057qib7 13415 5 -14 -14 NN cord-005453-4057qib7 13415 6 to to IN cord-005453-4057qib7 13415 7 d d NN cord-005453-4057qib7 13415 8 -12 -12 NNS cord-005453-4057qib7 13415 9 and and CC cord-005453-4057qib7 13415 10 on on IN cord-005453-4057qib7 13415 11 d-9 d-9 NN cord-005453-4057qib7 13415 12 to to IN cord-005453-4057qib7 13416 1 -d-5 -d-5 . cord-005453-4057qib7 13417 1 ( ( -LRB- cord-005453-4057qib7 13417 2 total total NN cord-005453-4057qib7 13417 3 600 600 CD cord-005453-4057qib7 13417 4 mg mg NNP cord-005453-4057qib7 13417 5 / / SYM cord-005453-4057qib7 13417 6 m m NNP cord-005453-4057qib7 13417 7 2 2 CD cord-005453-4057qib7 13417 8 ) ) -RRB- cord-005453-4057qib7 13417 9 . . . cord-005453-4057qib7 13418 1 A a DT cord-005453-4057qib7 13418 2 median median JJ cord-005453-4057qib7 13418 3 number number NN cord-005453-4057qib7 13418 4 of of IN cord-005453-4057qib7 13418 5 5.3 5.3 CD cord-005453-4057qib7 13418 6 ( ( -LRB- cord-005453-4057qib7 13418 7 3.7 3.7 CD cord-005453-4057qib7 13418 8 - - SYM cord-005453-4057qib7 13418 9 7 7 CD cord-005453-4057qib7 13418 10 ) ) -RRB- cord-005453-4057qib7 13418 11 CD34+/kg CD34+/kg NNP cord-005453-4057qib7 13418 12 was be VBD cord-005453-4057qib7 13418 13 infused infuse VBN cord-005453-4057qib7 13418 14 on on IN cord-005453-4057qib7 13418 15 d0 d0 NNP cord-005453-4057qib7 13418 16 . . . cord-005453-4057qib7 13419 1 Results result NNS cord-005453-4057qib7 13419 2 : : : cord-005453-4057qib7 13420 1 The the DT cord-005453-4057qib7 13420 2 median median JJ cord-005453-4057qib7 13420 3 recovery recovery NN cord-005453-4057qib7 13420 4 times time NNS cord-005453-4057qib7 13420 5 to to IN cord-005453-4057qib7 13420 6 WBC>1.0x10 wbc>1.0x10 NN cord-005453-4057qib7 13420 7 9 9 CD cord-005453-4057qib7 13420 8 /l /l NN cord-005453-4057qib7 13420 9 and and CC cord-005453-4057qib7 13420 10 to to IN cord-005453-4057qib7 13420 11 an an DT cord-005453-4057qib7 13420 12 unsupported unsupported JJ cord-005453-4057qib7 13420 13 Plt>20x10 Plt>20x10 NNP cord-005453-4057qib7 13420 14 11 11 CD cord-005453-4057qib7 13420 15 /l /l NNP cord-005453-4057qib7 13420 16 were be VBD cord-005453-4057qib7 13420 17 10 10 CD cord-005453-4057qib7 13420 18 ( ( -LRB- cord-005453-4057qib7 13420 19 7 7 CD cord-005453-4057qib7 13420 20 - - SYM cord-005453-4057qib7 13420 21 12 12 CD cord-005453-4057qib7 13420 22 ) ) -RRB- cord-005453-4057qib7 13420 23 and and CC cord-005453-4057qib7 13420 24 13 13 CD cord-005453-4057qib7 13420 25 ( ( -LRB- cord-005453-4057qib7 13420 26 9 9 CD cord-005453-4057qib7 13420 27 - - SYM cord-005453-4057qib7 13420 28 17 17 CD cord-005453-4057qib7 13420 29 ) ) -RRB- cord-005453-4057qib7 13420 30 days day NNS cord-005453-4057qib7 13420 31 , , , cord-005453-4057qib7 13420 32 respectively respectively RB cord-005453-4057qib7 13420 33 . . . cord-005453-4057qib7 13421 1 All all DT cord-005453-4057qib7 13421 2 pts pt NNS cord-005453-4057qib7 13421 3 experienced experience VBD cord-005453-4057qib7 13421 4 grade grade NN cord-005453-4057qib7 13421 5 4 4 CD cord-005453-4057qib7 13421 6 hematological hematological JJ cord-005453-4057qib7 13421 7 as as RB cord-005453-4057qib7 13421 8 well well RB cord-005453-4057qib7 13421 9 as as IN cord-005453-4057qib7 13421 10 infectious infectious JJ cord-005453-4057qib7 13421 11 toxicity toxicity NN cord-005453-4057qib7 13421 12 assessed assess VBN cord-005453-4057qib7 13421 13 by by IN cord-005453-4057qib7 13421 14 NCI NCI NNP cord-005453-4057qib7 13421 15 - - HYPH cord-005453-4057qib7 13421 16 CTC CTC NNP cord-005453-4057qib7 13421 17 score score NN cord-005453-4057qib7 13421 18 . . . cord-005453-4057qib7 13422 1 There there EX cord-005453-4057qib7 13422 2 were be VBD cord-005453-4057qib7 13422 3 7 7 CD cord-005453-4057qib7 13422 4 episodes episode NNS cord-005453-4057qib7 13422 5 of of IN cord-005453-4057qib7 13422 6 severe severe JJ cord-005453-4057qib7 13422 7 organ organ NN cord-005453-4057qib7 13422 8 toxicity toxicity NN cord-005453-4057qib7 13422 9 of of IN cord-005453-4057qib7 13422 10 grade grade NN cord-005453-4057qib7 13422 11 3 3 CD cord-005453-4057qib7 13422 12 occurring occur VBG cord-005453-4057qib7 13422 13 in in IN cord-005453-4057qib7 13422 14 4 4 CD cord-005453-4057qib7 13422 15 pts pt NNS cord-005453-4057qib7 13422 16 . . . cord-005453-4057qib7 13423 1 In in IN cord-005453-4057qib7 13423 2 4 4 CD cord-005453-4057qib7 13423 3 cases case NNS cord-005453-4057qib7 13423 4 we -PRON- PRP cord-005453-4057qib7 13423 5 observed observe VBD cord-005453-4057qib7 13423 6 a a DT cord-005453-4057qib7 13423 7 severe severe JJ cord-005453-4057qib7 13423 8 mucositis mucositis NN cord-005453-4057qib7 13423 9 , , , cord-005453-4057qib7 13423 10 in in IN cord-005453-4057qib7 13423 11 2 2 CD cord-005453-4057qib7 13423 12 cases case NNS cord-005453-4057qib7 13423 13 GI gi NN cord-005453-4057qib7 13423 14 toxicity toxicity NN cord-005453-4057qib7 13423 15 and and CC cord-005453-4057qib7 13423 16 1 1 CD cord-005453-4057qib7 13423 17 episode episode NN cord-005453-4057qib7 13423 18 of of IN cord-005453-4057qib7 13423 19 the the DT cord-005453-4057qib7 13423 20 erythema erythema JJ cord-005453-4057qib7 13423 21 multiforme multiforme NN cord-005453-4057qib7 13423 22 occurred occur VBD cord-005453-4057qib7 13423 23 . . . cord-005453-4057qib7 13424 1 One one CD cord-005453-4057qib7 13424 2 pt pt NN cord-005453-4057qib7 13424 3 revealed reveal VBD cord-005453-4057qib7 13424 4 a a DT cord-005453-4057qib7 13424 5 lifethreatening lifethreatening JJ cord-005453-4057qib7 13424 6 episode episode NN cord-005453-4057qib7 13424 7 of of IN cord-005453-4057qib7 13424 8 hypotension hypotension NN cord-005453-4057qib7 13424 9 of of IN cord-005453-4057qib7 13424 10 grade grade NN cord-005453-4057qib7 13424 11 4 4 CD cord-005453-4057qib7 13424 12 . . . cord-005453-4057qib7 13425 1 No no DT cord-005453-4057qib7 13425 2 transplant transplant NN cord-005453-4057qib7 13425 3 - - HYPH cord-005453-4057qib7 13425 4 related relate VBN cord-005453-4057qib7 13425 5 death death NN cord-005453-4057qib7 13425 6 occurred occur VBD cord-005453-4057qib7 13425 7 . . . cord-005453-4057qib7 13426 1 The the DT cord-005453-4057qib7 13426 2 median median JJ cord-005453-4057qib7 13426 3 number number NN cord-005453-4057qib7 13426 4 of of IN cord-005453-4057qib7 13426 5 transfused transfuse VBN cord-005453-4057qib7 13426 6 RBC RBC NNP cord-005453-4057qib7 13426 7 and and CC cord-005453-4057qib7 13426 8 Plt Plt NNP cord-005453-4057qib7 13426 9 doses dose NNS cord-005453-4057qib7 13426 10 was be VBD cord-005453-4057qib7 13426 11 3 3 CD cord-005453-4057qib7 13426 12 ( ( -LRB- cord-005453-4057qib7 13426 13 1 1 CD cord-005453-4057qib7 13426 14 - - SYM cord-005453-4057qib7 13426 15 4 4 CD cord-005453-4057qib7 13426 16 ) ) -RRB- cord-005453-4057qib7 13426 17 and and CC cord-005453-4057qib7 13426 18 6 6 CD cord-005453-4057qib7 13426 19 ( ( -LRB- cord-005453-4057qib7 13426 20 3 3 CD cord-005453-4057qib7 13426 21 - - SYM cord-005453-4057qib7 13426 22 8 8 CD cord-005453-4057qib7 13426 23 ) ) -RRB- cord-005453-4057qib7 13426 24 , , , cord-005453-4057qib7 13426 25 respectively respectively RB cord-005453-4057qib7 13426 26 . . . cord-005453-4057qib7 13427 1 All all DT cord-005453-4057qib7 13427 2 pts pt NNS cord-005453-4057qib7 13427 3 are be VBP cord-005453-4057qib7 13427 4 alive alive JJ cord-005453-4057qib7 13427 5 and and CC cord-005453-4057qib7 13427 6 well well RB cord-005453-4057qib7 13427 7 without without IN cord-005453-4057qib7 13427 8 signs sign NNS cord-005453-4057qib7 13427 9 of of IN cord-005453-4057qib7 13427 10 disease disease NN cord-005453-4057qib7 13427 11 progression progression NN cord-005453-4057qib7 13427 12 in in IN cord-005453-4057qib7 13427 13 complete complete JJ cord-005453-4057qib7 13427 14 hematological hematological JJ cord-005453-4057qib7 13427 15 recovery recovery NN cord-005453-4057qib7 13427 16 with with IN cord-005453-4057qib7 13427 17 a a DT cord-005453-4057qib7 13427 18 limited limited JJ cord-005453-4057qib7 13427 19 follow follow NN cord-005453-4057qib7 13427 20 - - HYPH cord-005453-4057qib7 13427 21 up up NN cord-005453-4057qib7 13427 22 of of IN cord-005453-4057qib7 13427 23 5.3 5.3 CD cord-005453-4057qib7 13427 24 ( ( -LRB- cord-005453-4057qib7 13427 25 4 4 CD cord-005453-4057qib7 13427 26 - - SYM cord-005453-4057qib7 13427 27 7 7 CD cord-005453-4057qib7 13427 28 ) ) -RRB- cord-005453-4057qib7 13427 29 mos mos NNP cord-005453-4057qib7 13427 30 . . . cord-005453-4057qib7 13428 1 from from IN cord-005453-4057qib7 13428 2 day day NN cord-005453-4057qib7 13428 3 0 0 CD cord-005453-4057qib7 13428 4 of of IN cord-005453-4057qib7 13428 5 HDCT HDCT NNP cord-005453-4057qib7 13428 6 . . . cord-005453-4057qib7 13429 1 Conclusions conclusion NNS cord-005453-4057qib7 13429 2 : : : cord-005453-4057qib7 13430 1 Although although IN cord-005453-4057qib7 13430 2 it -PRON- PRP cord-005453-4057qib7 13430 3 is be VBZ cord-005453-4057qib7 13430 4 rather rather RB cord-005453-4057qib7 13430 5 early early JJ cord-005453-4057qib7 13430 6 to to TO cord-005453-4057qib7 13430 7 evaluate evaluate VB cord-005453-4057qib7 13430 8 the the DT cord-005453-4057qib7 13430 9 efficacy efficacy NN cord-005453-4057qib7 13430 10 of of IN cord-005453-4057qib7 13430 11 the the DT cord-005453-4057qib7 13430 12 epigenetic epigenetic JJ cord-005453-4057qib7 13430 13 agent agent NN cord-005453-4057qib7 13430 14 's 's POS cord-005453-4057qib7 13430 15 inclusion inclusion NN cord-005453-4057qib7 13430 16 in in IN cord-005453-4057qib7 13430 17 the the DT cord-005453-4057qib7 13430 18 induction induction NN cord-005453-4057qib7 13430 19 and/or and/or CC cord-005453-4057qib7 13430 20 consolidation consolidation NN cord-005453-4057qib7 13430 21 phases phase NNS cord-005453-4057qib7 13430 22 of of IN cord-005453-4057qib7 13430 23 a a DT cord-005453-4057qib7 13430 24 very very RB cord-005453-4057qib7 13430 25 high high JJ cord-005453-4057qib7 13430 26 - - HYPH cord-005453-4057qib7 13430 27 risk risk NN cord-005453-4057qib7 13430 28 NB NB NNP cord-005453-4057qib7 13430 29 treatment treatment NN cord-005453-4057qib7 13430 30 , , , cord-005453-4057qib7 13430 31 we -PRON- PRP cord-005453-4057qib7 13430 32 can can MD cord-005453-4057qib7 13430 33 assume assume VB cord-005453-4057qib7 13430 34 that that IN cord-005453-4057qib7 13430 35 , , , cord-005453-4057qib7 13430 36 first first RB cord-005453-4057qib7 13430 37 , , , cord-005453-4057qib7 13430 38 the the DT cord-005453-4057qib7 13430 39 HDCT HDCT NNP cord-005453-4057qib7 13430 40 combining combine VBG cord-005453-4057qib7 13430 41 MIBG MIBG NNP cord-005453-4057qib7 13431 1 I -PRON- PRP cord-005453-4057qib7 13431 2 131 131 CD cord-005453-4057qib7 13431 3 and/or and/or CC cord-005453-4057qib7 13431 4 high high JJ cord-005453-4057qib7 13431 5 dose dose NN cord-005453-4057qib7 13431 6 of of IN cord-005453-4057qib7 13431 7 treosulfan treosulfan NNP cord-005453-4057qib7 13431 8 with with IN cord-005453-4057qib7 13431 9 epigenetic epigenetic JJ cord-005453-4057qib7 13431 10 agent agent NN cord-005453-4057qib7 13431 11 such such PDT cord-005453-4057qib7 13431 12 a a DT cord-005453-4057qib7 13431 13 5-azacitidine 5-azacitidine CD cord-005453-4057qib7 13431 14 was be VBD cord-005453-4057qib7 13431 15 feasible feasible JJ cord-005453-4057qib7 13431 16 and and CC cord-005453-4057qib7 13431 17 had have VBD cord-005453-4057qib7 13431 18 an an DT cord-005453-4057qib7 13431 19 acceptable acceptable JJ cord-005453-4057qib7 13431 20 toxicity toxicity NN cord-005453-4057qib7 13431 21 . . . cord-005453-4057qib7 13432 1 Second second RB cord-005453-4057qib7 13432 2 , , , cord-005453-4057qib7 13432 3 the the DT cord-005453-4057qib7 13432 4 " " `` cord-005453-4057qib7 13432 5 split split NN cord-005453-4057qib7 13432 6 " " '' cord-005453-4057qib7 13432 7 modality modality NN cord-005453-4057qib7 13432 8 of of IN cord-005453-4057qib7 13432 9 the the DT cord-005453-4057qib7 13432 10 treosulfan treosulfan NNP cord-005453-4057qib7 13432 11 use use NN cord-005453-4057qib7 13432 12 in in IN cord-005453-4057qib7 13432 13 conditioning conditioning NN cord-005453-4057qib7 13432 14 regimen regimen NN cord-005453-4057qib7 13432 15 would would MD cord-005453-4057qib7 13432 16 permit permit VB cord-005453-4057qib7 13432 17 to to TO cord-005453-4057qib7 13432 18 increase increase VB cord-005453-4057qib7 13432 19 the the DT cord-005453-4057qib7 13432 20 total total JJ cord-005453-4057qib7 13432 21 dose dose NN cord-005453-4057qib7 13432 22 of of IN cord-005453-4057qib7 13432 23 the the DT cord-005453-4057qib7 13432 24 alkylating alkylating JJ cord-005453-4057qib7 13432 25 agent agent NN cord-005453-4057qib7 13432 26 with with IN cord-005453-4057qib7 13432 27 no no DT cord-005453-4057qib7 13432 28 inacceptable inacceptable JJ cord-005453-4057qib7 13432 29 toxicity toxicity NN cord-005453-4057qib7 13432 30 . . . cord-005453-4057qib7 13433 1 Disclosure disclosure NN cord-005453-4057qib7 13433 2 : : : cord-005453-4057qib7 13433 3 Nothing nothing NN cord-005453-4057qib7 13433 4 to to TO cord-005453-4057qib7 13433 5 declare declare VB cord-005453-4057qib7 13433 6 Pre Pre NNP cord-005453-4057qib7 13433 7 - - JJ cord-005453-4057qib7 13433 8 and and CC cord-005453-4057qib7 13433 9 - - HYPH cord-005453-4057qib7 13433 10 post post NN cord-005453-4057qib7 13433 11 magnetic magnetic JJ cord-005453-4057qib7 13433 12 resonance resonance NN cord-005453-4057qib7 13433 13 imaging imaging NN cord-005453-4057qib7 13433 14 of of IN cord-005453-4057qib7 13433 15 hips hip NNS cord-005453-4057qib7 13433 16 and and CC cord-005453-4057qib7 13433 17 knees knee NNS cord-005453-4057qib7 13433 18 for for IN cord-005453-4057qib7 13433 19 detecting detect VBG cord-005453-4057qib7 13433 20 osteonecrosis osteonecrosis NN cord-005453-4057qib7 13433 21 in in IN cord-005453-4057qib7 13433 22 children child NNS cord-005453-4057qib7 13433 23 undergoing undergo VBG cord-005453-4057qib7 13433 24 hematopoietic hematopoietic JJ cord-005453-4057qib7 13433 25 cell cell NN cord-005453-4057qib7 13433 26 transplantation transplantation NN cord-005453-4057qib7 13433 27 : : : cord-005453-4057qib7 13433 28 In in IN cord-005453-4057qib7 13433 29 whom whom WP cord-005453-4057qib7 13433 30 is be VBZ cord-005453-4057qib7 13433 31 it -PRON- PRP cord-005453-4057qib7 13433 32 necessary necessary JJ cord-005453-4057qib7 13433 33 ? ? . cord-005453-4057qib7 13434 1 Ali Ali NNP cord-005453-4057qib7 13434 2 Y Y NNP cord-005453-4057qib7 13434 3 Suliman Suliman NNP cord-005453-4057qib7 13434 4 1 1 CD cord-005453-4057qib7 13434 5 , , , cord-005453-4057qib7 13434 6 Sue Sue NNP cord-005453-4057qib7 13434 7 C C NNP cord-005453-4057qib7 13434 8 Kaste Kaste NNP cord-005453-4057qib7 13434 9 2 2 CD cord-005453-4057qib7 13434 10 , , , cord-005453-4057qib7 13434 11 Ying Ying NNP cord-005453-4057qib7 13434 12 Li Li NNP cord-005453-4057qib7 13434 13 1 1 CD cord-005453-4057qib7 13434 14 , , , cord-005453-4057qib7 13434 15 Dinesh Dinesh NNP cord-005453-4057qib7 13434 16 Keerthi Keerthi NNP cord-005453-4057qib7 13434 17 1 1 CD cord-005453-4057qib7 13434 18 , , , cord-005453-4057qib7 13434 19 Guolian Guolian NNP cord-005453-4057qib7 13434 20 Kang Kang NNP cord-005453-4057qib7 13434 21 1 1 CD cord-005453-4057qib7 13434 22 , , , cord-005453-4057qib7 13434 23 Brandon Brandon NNP cord-005453-4057qib7 13434 24 M M NNP cord-005453-4057qib7 13434 25 Triplett Triplett NNP cord-005453-4057qib7 13434 26 1 1 CD cord-005453-4057qib7 13434 27 , , , cord-005453-4057qib7 13434 28 Ashok Ashok NNP cord-005453-4057qib7 13434 29 Srinivasan Srinivasan NNP cord-005453-4057qib7 13434 30 1 1 CD cord-005453-4057qib7 13434 31 between between IN cord-005453-4057qib7 13434 32 April April NNP cord-005453-4057qib7 13434 33 2016 2016 CD cord-005453-4057qib7 13434 34 and and CC cord-005453-4057qib7 13434 35 August August NNP cord-005453-4057qib7 13434 36 2017 2017 CD cord-005453-4057qib7 13434 37 at at IN cord-005453-4057qib7 13434 38 the the DT cord-005453-4057qib7 13434 39 University University NNP cord-005453-4057qib7 13434 40 Medical Medical NNP cord-005453-4057qib7 13434 41 Center Center NNP cord-005453-4057qib7 13434 42 Hamburg Hamburg NNP cord-005453-4057qib7 13434 43 - - HYPH cord-005453-4057qib7 13434 44 Eppendorf Eppendorf NNP cord-005453-4057qib7 13434 45 , , , cord-005453-4057qib7 13434 46 Germany Germany NNP cord-005453-4057qib7 13434 47 , , , cord-005453-4057qib7 13434 48 were be VBD cord-005453-4057qib7 13434 49 included include VBN cord-005453-4057qib7 13434 50 . . . cord-005453-4057qib7 13435 1 Total total JJ cord-005453-4057qib7 13435 2 and and CC cord-005453-4057qib7 13435 3 active active JJ cord-005453-4057qib7 13435 4 rATG ratg JJ cord-005453-4057qib7 13435 5 plasma plasma NN cord-005453-4057qib7 13435 6 levels level NNS cord-005453-4057qib7 13435 7 were be VBD cord-005453-4057qib7 13435 8 analyzed analyze VBN cord-005453-4057qib7 13435 9 by by IN cord-005453-4057qib7 13435 10 ELISA ELISA NNP cord-005453-4057qib7 13435 11 and and CC cord-005453-4057qib7 13435 12 flow flow NN cord-005453-4057qib7 13435 13 cytometry cytometry NN cord-005453-4057qib7 13435 14 , , , cord-005453-4057qib7 13435 15 respectively respectively RB cord-005453-4057qib7 13435 16 . . . cord-005453-4057qib7 13436 1 Primary primary JJ cord-005453-4057qib7 13436 2 endpoint endpoint NN cord-005453-4057qib7 13436 3 of of IN cord-005453-4057qib7 13436 4 the the DT cord-005453-4057qib7 13436 5 study study NN cord-005453-4057qib7 13436 6 was be VBD cord-005453-4057qib7 13436 7 exposure exposure NN cord-005453-4057qib7 13436 8 to to IN cord-005453-4057qib7 13436 9 rATG ratg VB cord-005453-4057qib7 13436 10 . . . cord-005453-4057qib7 13437 1 Secondary secondary JJ cord-005453-4057qib7 13437 2 endpoints endpoint NNS cord-005453-4057qib7 13437 3 included include VBD cord-005453-4057qib7 13437 4 transplant transplant NN cord-005453-4057qib7 13437 5 - - HYPH cord-005453-4057qib7 13437 6 related relate VBN cord-005453-4057qib7 13437 7 mortality mortality NN cord-005453-4057qib7 13437 8 , , , cord-005453-4057qib7 13437 9 incidence incidence NN cord-005453-4057qib7 13437 10 of of IN cord-005453-4057qib7 13437 11 acute acute JJ cord-005453-4057qib7 13437 12 and and CC cord-005453-4057qib7 13437 13 chronic chronic JJ cord-005453-4057qib7 13437 14 GvHD GvHD NNP cord-005453-4057qib7 13437 15 , , , cord-005453-4057qib7 13437 16 immune immune JJ cord-005453-4057qib7 13437 17 reconstitution reconstitution NN cord-005453-4057qib7 13437 18 , , , cord-005453-4057qib7 13437 19 chimerism chimerism NN cord-005453-4057qib7 13437 20 , , , cord-005453-4057qib7 13437 21 rejection rejection NN cord-005453-4057qib7 13437 22 and and CC cord-005453-4057qib7 13437 23 viral viral JJ cord-005453-4057qib7 13437 24 infections infection NNS cord-005453-4057qib7 13437 25 . . . cord-005453-4057qib7 13438 1 Patients patient NNS cord-005453-4057qib7 13438 2 were be VBD cord-005453-4057qib7 13438 3 monitored monitor VBN cord-005453-4057qib7 13438 4 at at IN cord-005453-4057qib7 13438 5 least least RBS cord-005453-4057qib7 13438 6 100 100 CD cord-005453-4057qib7 13438 7 days day NNS cord-005453-4057qib7 13438 8 post post VBP cord-005453-4057qib7 13438 9 transplantation transplantation NN cord-005453-4057qib7 13438 10 . . . cord-005453-4057qib7 13439 1 Statistical statistical JJ cord-005453-4057qib7 13439 2 analyses analysis NNS cord-005453-4057qib7 13439 3 were be VBD cord-005453-4057qib7 13439 4 performed perform VBN cord-005453-4057qib7 13439 5 using use VBG cord-005453-4057qib7 13439 6 IBM IBM NNP cord-005453-4057qib7 13439 7 SPSS SPSS NNP cord-005453-4057qib7 13439 8 Statistics Statistics NNP cord-005453-4057qib7 13439 9 24 24 CD cord-005453-4057qib7 13439 10 software software NN cord-005453-4057qib7 13439 11 , , , cord-005453-4057qib7 13439 12 or or CC cord-005453-4057qib7 13439 13 GraphPad GraphPad NNP cord-005453-4057qib7 13439 14 Prism Prism NNP cord-005453-4057qib7 13439 15 5 5 CD cord-005453-4057qib7 13439 16 software software NN cord-005453-4057qib7 13439 17 . . . cord-005453-4057qib7 13440 1 Results result NNS cord-005453-4057qib7 13440 2 : : : cord-005453-4057qib7 13441 1 Median median JJ cord-005453-4057qib7 13441 2 total total NN cord-005453-4057qib7 13442 1 Grafalon Grafalon NNP cord-005453-4057qib7 13442 2 ™ ™ NN cord-005453-4057qib7 13442 3 and and CC cord-005453-4057qib7 13442 4 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13443 1 ™ ™ `` cord-005453-4057qib7 13443 2 peak peak NN cord-005453-4057qib7 13443 3 plasma plasma NN cord-005453-4057qib7 13443 4 levels level NNS cord-005453-4057qib7 13443 5 were be VBD cord-005453-4057qib7 13443 6 419.0 419.0 CD cord-005453-4057qib7 13443 7 μg μg NNS cord-005453-4057qib7 13443 8 / / SYM cord-005453-4057qib7 13443 9 ml ml NNP cord-005453-4057qib7 13443 10 and and CC cord-005453-4057qib7 13443 11 60.4 60.4 CD cord-005453-4057qib7 13443 12 μg μg NNP cord-005453-4057qib7 13443 13 / / SYM cord-005453-4057qib7 13443 14 ml ml NNS cord-005453-4057qib7 13443 15 , , , cord-005453-4057qib7 13443 16 respectively respectively RB cord-005453-4057qib7 13443 17 ; ; : cord-005453-4057qib7 13443 18 median median JJ cord-005453-4057qib7 13443 19 active active JJ cord-005453-4057qib7 13443 20 Grafalon Grafalon NNP cord-005453-4057qib7 13443 21 ™ ™ NN cord-005453-4057qib7 13443 22 and and CC cord-005453-4057qib7 13443 23 Thymoglobu Thymoglobu NNP cord-005453-4057qib7 13443 24 - - HYPH cord-005453-4057qib7 13443 25 line line NN cord-005453-4057qib7 13443 26 ™ ™ HYPH cord-005453-4057qib7 13443 27 peak peak NN cord-005453-4057qib7 13443 28 plasma plasma NN cord-005453-4057qib7 13443 29 levels level NNS cord-005453-4057qib7 13443 30 ( ( -LRB- cord-005453-4057qib7 13443 31 aPPL appl NN cord-005453-4057qib7 13443 32 ) ) -RRB- cord-005453-4057qib7 13443 33 were be VBD cord-005453-4057qib7 13443 34 77.9 77.9 CD cord-005453-4057qib7 13443 35 μg μg NNP cord-005453-4057qib7 13443 36 / / SYM cord-005453-4057qib7 13443 37 ml ml NN cord-005453-4057qib7 13443 38 and and CC cord-005453-4057qib7 13443 39 8.11 8.11 CD cord-005453-4057qib7 13443 40 μg μg NNP cord-005453-4057qib7 13443 41 / / SYM cord-005453-4057qib7 13443 42 ml ml NNS cord-005453-4057qib7 13443 43 , , , cord-005453-4057qib7 13443 44 respectively respectively RB cord-005453-4057qib7 13443 45 . . . cord-005453-4057qib7 13444 1 Active active JJ cord-005453-4057qib7 13444 2 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13444 3 ™ ™ HYPH cord-005453-4057qib7 13444 4 plasma plasma NN cord-005453-4057qib7 13444 5 levels level NNS cord-005453-4057qib7 13444 6 showed show VBD cord-005453-4057qib7 13444 7 highly highly RB cord-005453-4057qib7 13444 8 variable variable JJ cord-005453-4057qib7 13444 9 pharmacokinetics pharmacokinetic NNS cord-005453-4057qib7 13444 10 compared compare VBN cord-005453-4057qib7 13444 11 to to IN cord-005453-4057qib7 13444 12 Grafalon Grafalon NNP cord-005453-4057qib7 13444 13 ™ ™ NN cord-005453-4057qib7 13444 14 . . . cord-005453-4057qib7 13445 1 Neither neither CC cord-005453-4057qib7 13445 2 Grafalon Grafalon NNP cord-005453-4057qib7 13445 3 ™ ™ NN cord-005453-4057qib7 13445 4 nor nor CC cord-005453-4057qib7 13445 5 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13445 6 ™ ™ NN cord-005453-4057qib7 13445 7 exposure exposure NN cord-005453-4057qib7 13445 8 correlated correlate VBN cord-005453-4057qib7 13445 9 with with IN cord-005453-4057qib7 13445 10 lymphocyte lymphocyte NN cord-005453-4057qib7 13445 11 count count NN cord-005453-4057qib7 13445 12 prior prior RB cord-005453-4057qib7 13445 13 to to IN cord-005453-4057qib7 13445 14 transplantation transplantation NN cord-005453-4057qib7 13445 15 , , , cord-005453-4057qib7 13445 16 cell cell NN cord-005453-4057qib7 13445 17 count count NN cord-005453-4057qib7 13445 18 in in IN cord-005453-4057qib7 13445 19 the the DT cord-005453-4057qib7 13445 20 graft graft NN cord-005453-4057qib7 13445 21 ( ( -LRB- cord-005453-4057qib7 13445 22 WBC WBC NNP cord-005453-4057qib7 13445 23 , , , cord-005453-4057qib7 13445 24 MNC MNC NNP cord-005453-4057qib7 13445 25 , , , cord-005453-4057qib7 13445 26 T T NNP cord-005453-4057qib7 13445 27 cells cell NNS cord-005453-4057qib7 13445 28 ) ) -RRB- cord-005453-4057qib7 13445 29 , , , cord-005453-4057qib7 13445 30 age age NN cord-005453-4057qib7 13445 31 , , , cord-005453-4057qib7 13445 32 body body NN cord-005453-4057qib7 13445 33 weight weight NN cord-005453-4057qib7 13445 34 or or CC cord-005453-4057qib7 13445 35 body body NN cord-005453-4057qib7 13445 36 surface surface NN cord-005453-4057qib7 13445 37 area area NN cord-005453-4057qib7 13445 38 ( ( -LRB- cord-005453-4057qib7 13445 39 BSA BSA NNP cord-005453-4057qib7 13445 40 ) ) -RRB- cord-005453-4057qib7 13445 41 . . . cord-005453-4057qib7 13446 1 This this DT cord-005453-4057qib7 13446 2 is be VBZ cord-005453-4057qib7 13446 3 indicative indicative JJ cord-005453-4057qib7 13446 4 for for IN cord-005453-4057qib7 13446 5 a a DT cord-005453-4057qib7 13446 6 saturation saturation NN cord-005453-4057qib7 13446 7 effect effect NN cord-005453-4057qib7 13446 8 in in IN cord-005453-4057qib7 13446 9 both both DT cord-005453-4057qib7 13446 10 groups group NNS cord-005453-4057qib7 13446 11 . . . cord-005453-4057qib7 13447 1 To to TO cord-005453-4057qib7 13447 2 correlate correlate VB cord-005453-4057qib7 13447 3 high high JJ cord-005453-4057qib7 13447 4 or or CC cord-005453-4057qib7 13447 5 low low JJ cord-005453-4057qib7 13447 6 rATG ratg JJ cord-005453-4057qib7 13447 7 exposure exposure NN cord-005453-4057qib7 13447 8 with with IN cord-005453-4057qib7 13447 9 clinical clinical JJ cord-005453-4057qib7 13447 10 outcome outcome NN cord-005453-4057qib7 13447 11 parameters parameter NNS cord-005453-4057qib7 13447 12 , , , cord-005453-4057qib7 13447 13 we -PRON- PRP cord-005453-4057qib7 13447 14 built build VBD cord-005453-4057qib7 13447 15 two two CD cord-005453-4057qib7 13447 16 groups group NNS cord-005453-4057qib7 13447 17 within within IN cord-005453-4057qib7 13447 18 each each DT cord-005453-4057qib7 13447 19 patient patient JJ cord-005453-4057qib7 13447 20 cohort cohort NN cord-005453-4057qib7 13447 21 by by IN cord-005453-4057qib7 13447 22 median median NN cord-005453-4057qib7 13447 23 aPPL appl NN cord-005453-4057qib7 13447 24 . . . cord-005453-4057qib7 13448 1 The the DT cord-005453-4057qib7 13448 2 incidence incidence NN cord-005453-4057qib7 13448 3 of of IN cord-005453-4057qib7 13448 4 GvHD GvHD NNP cord-005453-4057qib7 13448 5 was be VBD cord-005453-4057qib7 13448 6 not not RB cord-005453-4057qib7 13448 7 dependent dependent JJ cord-005453-4057qib7 13448 8 on on IN cord-005453-4057qib7 13448 9 high high JJ cord-005453-4057qib7 13448 10 or or CC cord-005453-4057qib7 13448 11 low low JJ cord-005453-4057qib7 13448 12 rATG ratg JJ cord-005453-4057qib7 13448 13 exposure exposure NN cord-005453-4057qib7 13448 14 . . . cord-005453-4057qib7 13449 1 Until until IN cord-005453-4057qib7 13449 2 day day NN cord-005453-4057qib7 13449 3 100 100 CD cord-005453-4057qib7 13449 4 post post NN cord-005453-4057qib7 13449 5 HSCT HSCT NNP cord-005453-4057qib7 13449 6 , , , cord-005453-4057qib7 13449 7 49 49 CD cord-005453-4057qib7 13449 8 viral viral JJ cord-005453-4057qib7 13449 9 infections infection NNS cord-005453-4057qib7 13449 10 or or CC cord-005453-4057qib7 13449 11 reactivations reactivation NNS cord-005453-4057qib7 13449 12 ( ( -LRB- cord-005453-4057qib7 13449 13 EBV EBV NNP cord-005453-4057qib7 13449 14 , , , cord-005453-4057qib7 13449 15 CMV CMV NNP cord-005453-4057qib7 13449 16 , , , cord-005453-4057qib7 13449 17 ADV ADV NNP cord-005453-4057qib7 13449 18 , , , cord-005453-4057qib7 13449 19 HHV6 HHV6 NNP cord-005453-4057qib7 13449 20 , , , cord-005453-4057qib7 13449 21 BKV BKV NNP cord-005453-4057qib7 13449 22 ) ) -RRB- cord-005453-4057qib7 13449 23 occurred occur VBD cord-005453-4057qib7 13449 24 in in IN cord-005453-4057qib7 13449 25 the the DT cord-005453-4057qib7 13449 26 32 32 CD cord-005453-4057qib7 13449 27 patients patient NNS cord-005453-4057qib7 13449 28 . . . cord-005453-4057qib7 13450 1 Interestingly interestingly RB cord-005453-4057qib7 13450 2 , , , cord-005453-4057qib7 13450 3 ADV ADV NNP cord-005453-4057qib7 13450 4 infections infection NNS cord-005453-4057qib7 13450 5 affected affect VBN cord-005453-4057qib7 13450 6 only only JJ cord-005453-4057qib7 13450 7 children child NNS cord-005453-4057qib7 13450 8 with with IN cord-005453-4057qib7 13450 9 high high JJ cord-005453-4057qib7 13450 10 rATG ratg JJ cord-005453-4057qib7 13450 11 exposure exposure NN cord-005453-4057qib7 13450 12 . . . cord-005453-4057qib7 13451 1 The the DT cord-005453-4057qib7 13451 2 median median JJ cord-005453-4057qib7 13451 3 time time NN cord-005453-4057qib7 13451 4 to to IN cord-005453-4057qib7 13451 5 leukocyte leukocyte NN cord-005453-4057qib7 13451 6 engraftment engraftment NN cord-005453-4057qib7 13451 7 was be VBD cord-005453-4057qib7 13451 8 not not RB cord-005453-4057qib7 13451 9 significantly significantly RB cord-005453-4057qib7 13451 10 longer long RBR cord-005453-4057qib7 13451 11 in in IN cord-005453-4057qib7 13451 12 the the DT cord-005453-4057qib7 13451 13 high high JJ cord-005453-4057qib7 13451 14 rATG ratg JJ cord-005453-4057qib7 13451 15 groups group NNS cord-005453-4057qib7 13451 16 compared compare VBN cord-005453-4057qib7 13451 17 to to IN cord-005453-4057qib7 13451 18 the the DT cord-005453-4057qib7 13451 19 low low JJ cord-005453-4057qib7 13451 20 rATG ratg JJ cord-005453-4057qib7 13451 21 groups group NNS cord-005453-4057qib7 13451 22 ( ( -LRB- cord-005453-4057qib7 13451 23 17 17 CD cord-005453-4057qib7 13451 24 to to TO cord-005453-4057qib7 13451 25 16 16 CD cord-005453-4057qib7 13451 26 days day NNS cord-005453-4057qib7 13451 27 for for IN cord-005453-4057qib7 13451 28 Grafalon Grafalon NNP cord-005453-4057qib7 13451 29 ™ ™ NN cord-005453-4057qib7 13451 30 , , , cord-005453-4057qib7 13451 31 and and CC cord-005453-4057qib7 13451 32 14 14 CD cord-005453-4057qib7 13451 33 to to TO cord-005453-4057qib7 13451 34 16 16 CD cord-005453-4057qib7 13451 35 days day NNS cord-005453-4057qib7 13451 36 for for IN cord-005453-4057qib7 13451 37 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13451 38 ™ ™ NN cord-005453-4057qib7 13451 39 ) ) -RRB- cord-005453-4057qib7 13451 40 . . . cord-005453-4057qib7 13452 1 There there EX cord-005453-4057qib7 13452 2 was be VBD cord-005453-4057qib7 13452 3 a a DT cord-005453-4057qib7 13452 4 decreased decrease VBN cord-005453-4057qib7 13452 5 and/or and/or CC cord-005453-4057qib7 13452 6 delayed delay VBN cord-005453-4057qib7 13452 7 recovery recovery NN cord-005453-4057qib7 13452 8 of of IN cord-005453-4057qib7 13452 9 CD3 CD3 NNP cord-005453-4057qib7 13452 10 + + CC cord-005453-4057qib7 13452 11 , , , cord-005453-4057qib7 13452 12 CD4 CD4 NNP cord-005453-4057qib7 13452 13 + + CC cord-005453-4057qib7 13452 14 and and CC cord-005453-4057qib7 13452 15 CD8 CD8 NNP cord-005453-4057qib7 13452 16 + + CC cord-005453-4057qib7 13452 17 T T NNP cord-005453-4057qib7 13452 18 cell cell NN cord-005453-4057qib7 13452 19 reconstitution reconstitution NN cord-005453-4057qib7 13452 20 , , , cord-005453-4057qib7 13452 21 but but CC cord-005453-4057qib7 13452 22 not not RB cord-005453-4057qib7 13452 23 of of IN cord-005453-4057qib7 13452 24 B b NN cord-005453-4057qib7 13452 25 cells cell NNS cord-005453-4057qib7 13452 26 and and CC cord-005453-4057qib7 13452 27 NK NK NNP cord-005453-4057qib7 13452 28 cells cell NNS cord-005453-4057qib7 13452 29 in in IN cord-005453-4057qib7 13452 30 the the DT cord-005453-4057qib7 13452 31 high high JJ cord-005453-4057qib7 13452 32 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13452 33 ™ ™ HYPH cord-005453-4057qib7 13452 34 exposure exposure NN cord-005453-4057qib7 13452 35 group group NN cord-005453-4057qib7 13452 36 compared compare VBN cord-005453-4057qib7 13452 37 to to IN cord-005453-4057qib7 13452 38 the the DT cord-005453-4057qib7 13452 39 low low JJ cord-005453-4057qib7 13452 40 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13452 41 ™ ™ HYPH cord-005453-4057qib7 13452 42 exposure exposure NN cord-005453-4057qib7 13452 43 group group NN cord-005453-4057qib7 13452 44 . . . cord-005453-4057qib7 13453 1 Overall overall JJ cord-005453-4057qib7 13453 2 survival survival NN cord-005453-4057qib7 13453 3 was be VBD cord-005453-4057qib7 13453 4 not not RB cord-005453-4057qib7 13453 5 statistically statistically RB cord-005453-4057qib7 13453 6 significant significant JJ cord-005453-4057qib7 13453 7 with with IN cord-005453-4057qib7 13453 8 80 80 CD cord-005453-4057qib7 13453 9 % % NN cord-005453-4057qib7 13453 10 in in IN cord-005453-4057qib7 13453 11 the the DT cord-005453-4057qib7 13453 12 Grafalon Grafalon NNP cord-005453-4057qib7 13453 13 ™ ™ NN cord-005453-4057qib7 13453 14 and and CC cord-005453-4057qib7 13453 15 95.5 95.5 CD cord-005453-4057qib7 13453 16 % % NN cord-005453-4057qib7 13453 17 in in IN cord-005453-4057qib7 13453 18 the the DT cord-005453-4057qib7 13453 19 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13453 20 ™ ™ NN cord-005453-4057qib7 13453 21 group group NN cord-005453-4057qib7 13453 22 without without IN cord-005453-4057qib7 13453 23 influence influence NN cord-005453-4057qib7 13453 24 of of IN cord-005453-4057qib7 13453 25 rATG ratg JJ cord-005453-4057qib7 13453 26 exposure exposure NN cord-005453-4057qib7 13453 27 . . . cord-005453-4057qib7 13454 1 Conclusions conclusion NNS cord-005453-4057qib7 13454 2 : : : cord-005453-4057qib7 13455 1 High high JJ cord-005453-4057qib7 13455 2 and and CC cord-005453-4057qib7 13455 3 low low JJ cord-005453-4057qib7 13455 4 exposure exposure NN cord-005453-4057qib7 13455 5 to to IN cord-005453-4057qib7 13455 6 Grafalon Grafalon NNP cord-005453-4057qib7 13455 7 ™ ™ NN cord-005453-4057qib7 13455 8 or or CC cord-005453-4057qib7 13455 9 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13455 10 ™ ™ MD cord-005453-4057qib7 13455 11 did do VBD cord-005453-4057qib7 13455 12 not not RB cord-005453-4057qib7 13455 13 result result VB cord-005453-4057qib7 13455 14 in in IN cord-005453-4057qib7 13455 15 significant significant JJ cord-005453-4057qib7 13455 16 differences difference NNS cord-005453-4057qib7 13455 17 in in IN cord-005453-4057qib7 13455 18 outcome outcome NN cord-005453-4057qib7 13455 19 parameters parameter NNS cord-005453-4057qib7 13455 20 as as IN cord-005453-4057qib7 13455 21 incidence incidence NN cord-005453-4057qib7 13455 22 of of IN cord-005453-4057qib7 13455 23 survival survival NN cord-005453-4057qib7 13455 24 , , , cord-005453-4057qib7 13455 25 aGvHD agvhd NN cord-005453-4057qib7 13455 26 , , , cord-005453-4057qib7 13455 27 cGvHD cGvHD NNP cord-005453-4057qib7 13455 28 , , , cord-005453-4057qib7 13455 29 rejection rejection NN cord-005453-4057qib7 13455 30 , , , cord-005453-4057qib7 13455 31 or or CC cord-005453-4057qib7 13455 32 mixed mixed JJ cord-005453-4057qib7 13455 33 chimerism chimerism NN cord-005453-4057qib7 13455 34 in in IN cord-005453-4057qib7 13455 35 this this DT cord-005453-4057qib7 13455 36 limited limited JJ cord-005453-4057qib7 13455 37 cohort cohort NN cord-005453-4057qib7 13455 38 . . . cord-005453-4057qib7 13456 1 Delayed delayed JJ cord-005453-4057qib7 13456 2 and and CC cord-005453-4057qib7 13456 3 decreased decrease VBD cord-005453-4057qib7 13456 4 immune immune JJ cord-005453-4057qib7 13456 5 reconstitution reconstitution NN cord-005453-4057qib7 13456 6 in in IN cord-005453-4057qib7 13456 7 the the DT cord-005453-4057qib7 13456 8 high high JJ cord-005453-4057qib7 13456 9 rATG ratg JJ cord-005453-4057qib7 13456 10 exposure exposure NN cord-005453-4057qib7 13456 11 groups group NNS cord-005453-4057qib7 13456 12 did do VBD cord-005453-4057qib7 13456 13 not not RB cord-005453-4057qib7 13456 14 translate translate VB cord-005453-4057qib7 13456 15 into into IN cord-005453-4057qib7 13456 16 different different JJ cord-005453-4057qib7 13456 17 clinical clinical JJ cord-005453-4057qib7 13456 18 outcome outcome NN cord-005453-4057qib7 13456 19 parameters parameter NNS cord-005453-4057qib7 13456 20 . . . cord-005453-4057qib7 13457 1 ADV ADV NNP cord-005453-4057qib7 13457 2 infections infection NNS cord-005453-4057qib7 13457 3 only only RB cord-005453-4057qib7 13457 4 occurred occur VBD cord-005453-4057qib7 13457 5 in in IN cord-005453-4057qib7 13457 6 the the DT cord-005453-4057qib7 13457 7 high high JJ cord-005453-4057qib7 13457 8 rATG ratg JJ cord-005453-4057qib7 13457 9 exposure exposure NN cord-005453-4057qib7 13457 10 group group NN cord-005453-4057qib7 13457 11 . . . cord-005453-4057qib7 13458 1 Grafalon Grafalon NNP cord-005453-4057qib7 13458 2 ™ ™ NN cord-005453-4057qib7 13458 3 and and CC cord-005453-4057qib7 13458 4 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 13458 5 ™ ™ MD cord-005453-4057qib7 13458 6 showed show VBD cord-005453-4057qib7 13458 7 distinct distinct JJ cord-005453-4057qib7 13458 8 pharmacological pharmacological JJ cord-005453-4057qib7 13458 9 and and CC cord-005453-4057qib7 13458 10 immunological immunological JJ cord-005453-4057qib7 13458 11 differences difference NNS cord-005453-4057qib7 13458 12 in in IN cord-005453-4057qib7 13458 13 children child NNS cord-005453-4057qib7 13458 14 and and CC cord-005453-4057qib7 13458 15 larger large JJR cord-005453-4057qib7 13458 16 cohorts cohort NNS cord-005453-4057qib7 13458 17 are be VBP cord-005453-4057qib7 13458 18 needed need VBN cord-005453-4057qib7 13458 19 to to TO cord-005453-4057qib7 13458 20 detect detect VB cord-005453-4057qib7 13458 21 clinically clinically RB cord-005453-4057qib7 13458 22 significant significant JJ cord-005453-4057qib7 13458 23 differences difference NNS cord-005453-4057qib7 13458 24 and and CC cord-005453-4057qib7 13458 25 adjust adjust VB cord-005453-4057qib7 13458 26 dosing dose VBG cord-005453-4057qib7 13458 27 regimens regimen NNS cord-005453-4057qib7 13458 28 individually individually RB cord-005453-4057qib7 13458 29 . . . cord-005453-4057qib7 13459 1 Disclosure disclosure NN cord-005453-4057qib7 13459 2 : : : cord-005453-4057qib7 13459 3 Nothing nothing NN cord-005453-4057qib7 13459 4 to to TO cord-005453-4057qib7 13459 5 declare declare VB cord-005453-4057qib7 13459 6 Background background NN cord-005453-4057qib7 13459 7 : : : cord-005453-4057qib7 13460 1 The the DT cord-005453-4057qib7 13460 2 optimal optimal JJ cord-005453-4057qib7 13460 3 conditioning conditioning NN cord-005453-4057qib7 13460 4 regimen regimen NN cord-005453-4057qib7 13460 5 for for IN cord-005453-4057qib7 13460 6 allogeneic allogeneic JJ cord-005453-4057qib7 13460 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 13460 8 cell cell NN cord-005453-4057qib7 13460 9 transplantation transplantation NN cord-005453-4057qib7 13460 10 ( ( -LRB- cord-005453-4057qib7 13460 11 alloHCT alloHCT NNP cord-005453-4057qib7 13460 12 ) ) -RRB- cord-005453-4057qib7 13460 13 in in IN cord-005453-4057qib7 13460 14 children child NNS cord-005453-4057qib7 13460 15 with with IN cord-005453-4057qib7 13460 16 myeloid myeloid JJ cord-005453-4057qib7 13460 17 malignancies malignancy NNS cord-005453-4057qib7 13460 18 remains remain VBZ cord-005453-4057qib7 13460 19 undefined undefined JJ cord-005453-4057qib7 13460 20 , , , cord-005453-4057qib7 13460 21 particularly particularly RB cord-005453-4057qib7 13460 22 when when WRB cord-005453-4057qib7 13460 23 reduced reduce VBN cord-005453-4057qib7 13460 24 - - HYPH cord-005453-4057qib7 13460 25 intensity intensity NN cord-005453-4057qib7 13460 26 conditioning conditioning NN cord-005453-4057qib7 13460 27 ( ( -LRB- cord-005453-4057qib7 13460 28 RIC RIC NNP cord-005453-4057qib7 13460 29 ) ) -RRB- cord-005453-4057qib7 13460 30 regimens regimen NNS cord-005453-4057qib7 13460 31 are be VBP cord-005453-4057qib7 13460 32 utilized utilize VBN cord-005453-4057qib7 13460 33 . . . cord-005453-4057qib7 13461 1 Methods method NNS cord-005453-4057qib7 13461 2 : : : cord-005453-4057qib7 13462 1 We -PRON- PRP cord-005453-4057qib7 13462 2 performed perform VBD cord-005453-4057qib7 13462 3 a a DT cord-005453-4057qib7 13462 4 retrospective retrospective JJ cord-005453-4057qib7 13462 5 review review NN cord-005453-4057qib7 13462 6 of of IN cord-005453-4057qib7 13462 7 children child NNS cord-005453-4057qib7 13462 8 undergoing undergo VBG cord-005453-4057qib7 13462 9 alloHCT alloHCT NNP cord-005453-4057qib7 13462 10 for for IN cord-005453-4057qib7 13462 11 acute acute JJ cord-005453-4057qib7 13462 12 myeloid myeloid NN cord-005453-4057qib7 13462 13 leukemia leukemia NN cord-005453-4057qib7 13462 14 ( ( -LRB- cord-005453-4057qib7 13462 15 AML AML NNP cord-005453-4057qib7 13462 16 ) ) -RRB- cord-005453-4057qib7 13462 17 and and CC cord-005453-4057qib7 13462 18 myelodysplasia myelodysplasia NNP cord-005453-4057qib7 13462 19 - - HYPH cord-005453-4057qib7 13462 20 related relate VBN cord-005453-4057qib7 13462 21 AML AML NNP cord-005453-4057qib7 13462 22 ( ( -LRB- cord-005453-4057qib7 13462 23 MDR MDR NNP cord-005453-4057qib7 13462 24 - - HYPH cord-005453-4057qib7 13462 25 AML AML NNP cord-005453-4057qib7 13462 26 ) ) -RRB- cord-005453-4057qib7 13462 27 over over IN cord-005453-4057qib7 13462 28 a a DT cord-005453-4057qib7 13462 29 10 10 CD cord-005453-4057qib7 13462 30 year year NN cord-005453-4057qib7 13462 31 period period NN cord-005453-4057qib7 13462 32 ( ( -LRB- cord-005453-4057qib7 13462 33 2008 2008 CD cord-005453-4057qib7 13462 34 - - SYM cord-005453-4057qib7 13462 35 2018 2018 CD cord-005453-4057qib7 13462 36 ) ) -RRB- cord-005453-4057qib7 13462 37 at at IN cord-005453-4057qib7 13462 38 our -PRON- PRP$ cord-005453-4057qib7 13462 39 institution institution NN cord-005453-4057qib7 13462 40 , , , cord-005453-4057qib7 13462 41 comparing compare VBG cord-005453-4057qib7 13462 42 the the DT cord-005453-4057qib7 13462 43 outcomes outcome NNS cord-005453-4057qib7 13462 44 of of IN cord-005453-4057qib7 13462 45 those those DT cord-005453-4057qib7 13462 46 who who WP cord-005453-4057qib7 13462 47 received receive VBD cord-005453-4057qib7 13462 48 either either CC cord-005453-4057qib7 13462 49 a a DT cord-005453-4057qib7 13462 50 busulfan busulfan NN cord-005453-4057qib7 13462 51 ( ( -LRB- cord-005453-4057qib7 13462 52 Bu)-or Bu)-or NNP cord-005453-4057qib7 13462 53 melphalan melphalan NNP cord-005453-4057qib7 13462 54 / / SYM cord-005453-4057qib7 13462 55 thiotepa thiotepa NNP cord-005453-4057qib7 13463 1 ( ( -LRB- cord-005453-4057qib7 13463 2 Mel Mel NNP cord-005453-4057qib7 13463 3 / / SYM cord-005453-4057qib7 13463 4 Thio)-based Thio)-based NNP cord-005453-4057qib7 13463 5 conditioning conditioning NN cord-005453-4057qib7 13463 6 regimen regimen NN cord-005453-4057qib7 13463 7 . . . cord-005453-4057qib7 13464 1 Results result NNS cord-005453-4057qib7 13464 2 : : : cord-005453-4057qib7 13465 1 A a DT cord-005453-4057qib7 13465 2 total total NN cord-005453-4057qib7 13465 3 of of IN cord-005453-4057qib7 13465 4 49 49 CD cord-005453-4057qib7 13465 5 patients patient NNS cord-005453-4057qib7 13465 6 were be VBD cord-005453-4057qib7 13465 7 analyzed analyze VBN cord-005453-4057qib7 13465 8 . . . cord-005453-4057qib7 13466 1 Twentyone Twentyone NNP cord-005453-4057qib7 13466 2 received receive VBD cord-005453-4057qib7 13466 3 fludarabine fludarabine NN cord-005453-4057qib7 13466 4 / / SYM cord-005453-4057qib7 13466 5 melphalan melphalan NNP cord-005453-4057qib7 13466 6 / / SYM cord-005453-4057qib7 13466 7 thiotepa thiotepa NNP cord-005453-4057qib7 13466 8 and and CC cord-005453-4057qib7 13466 9 28 28 CD cord-005453-4057qib7 13466 10 received receive VBD cord-005453-4057qib7 13466 11 myeloablative myeloablative NNP cord-005453-4057qib7 13466 12 busulfan busulfan NN cord-005453-4057qib7 13466 13 - - HYPH cord-005453-4057qib7 13466 14 based base VBN cord-005453-4057qib7 13466 15 conditioning conditioning NN cord-005453-4057qib7 13466 16 , , , cord-005453-4057qib7 13466 17 either either CC cord-005453-4057qib7 13466 18 in in IN cord-005453-4057qib7 13466 19 combination combination NN cord-005453-4057qib7 13466 20 with with IN cord-005453-4057qib7 13466 21 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 13466 22 ( ( -LRB- cord-005453-4057qib7 13466 23 N=19 N=19 NNP cord-005453-4057qib7 13466 24 ) ) -RRB- cord-005453-4057qib7 13466 25 or or CC cord-005453-4057qib7 13466 26 fludarabine fludarabine NNP cord-005453-4057qib7 13466 27 ( ( -LRB- cord-005453-4057qib7 13466 28 N=9 N=9 NNP cord-005453-4057qib7 13466 29 ) ) -RRB- cord-005453-4057qib7 13466 30 . . . cord-005453-4057qib7 13467 1 ATG ATG NNP cord-005453-4057qib7 13467 2 was be VBD cord-005453-4057qib7 13467 3 used use VBN cord-005453-4057qib7 13467 4 in in IN cord-005453-4057qib7 13467 5 27 27 CD cord-005453-4057qib7 13467 6 patients patient NNS cord-005453-4057qib7 13467 7 depending depend VBG cord-005453-4057qib7 13467 8 on on IN cord-005453-4057qib7 13467 9 donor donor NN cord-005453-4057qib7 13467 10 . . . cord-005453-4057qib7 13468 1 Recipients recipient NNS cord-005453-4057qib7 13468 2 of of IN cord-005453-4057qib7 13468 3 Mel Mel NNP cord-005453-4057qib7 13468 4 / / SYM cord-005453-4057qib7 13468 5 Thio Thio NNP cord-005453-4057qib7 13468 6 were be VBD cord-005453-4057qib7 13468 7 selected select VBN cord-005453-4057qib7 13468 8 for for IN cord-005453-4057qib7 13468 9 RIC RIC NNP cord-005453-4057qib7 13468 10 regimens regimen NNS cord-005453-4057qib7 13468 11 due due JJ cord-005453-4057qib7 13468 12 to to IN cord-005453-4057qib7 13468 13 pre pre JJ cord-005453-4057qib7 13468 14 - - JJ cord-005453-4057qib7 13468 15 transplant transplant JJ cord-005453-4057qib7 13468 16 comorbidities comorbiditie NNS cord-005453-4057qib7 13468 17 ( ( -LRB- cord-005453-4057qib7 13468 18 cardiac cardiac JJ cord-005453-4057qib7 13468 19 dysfunction dysfunction NN cord-005453-4057qib7 13468 20 , , , cord-005453-4057qib7 13468 21 N=9 N=9 NNP cord-005453-4057qib7 13468 22 , , , cord-005453-4057qib7 13468 23 3 3 CD cord-005453-4057qib7 13468 24 requiring require VBG cord-005453-4057qib7 13468 25 peri peri NN cord-005453-4057qib7 13468 26 - - HYPH cord-005453-4057qib7 13468 27 transplant transplant NN cord-005453-4057qib7 13468 28 milrinone milrinone NN cord-005453-4057qib7 13468 29 ) ) -RRB- cord-005453-4057qib7 13468 30 , , , cord-005453-4057qib7 13468 31 transplant transplant NN cord-005453-4057qib7 13468 32 during during IN cord-005453-4057qib7 13468 33 chemotherapy chemotherapy NN cord-005453-4057qib7 13468 34 - - HYPH cord-005453-4057qib7 13468 35 induced induce VBN cord-005453-4057qib7 13468 36 aplasia aplasia NNP cord-005453-4057qib7 13468 37 ( ( -LRB- cord-005453-4057qib7 13468 38 N=5 N=5 NNP cord-005453-4057qib7 13468 39 ) ) -RRB- cord-005453-4057qib7 13468 40 , , , cord-005453-4057qib7 13468 41 underlying underlie VBG cord-005453-4057qib7 13468 42 diagnosis diagnosis NN cord-005453-4057qib7 13468 43 of of IN cord-005453-4057qib7 13468 44 treatment treatment NN cord-005453-4057qib7 13468 45 - - HYPH cord-005453-4057qib7 13468 46 related relate VBN cord-005453-4057qib7 13468 47 AML AML NNP cord-005453-4057qib7 13468 48 ( ( -LRB- cord-005453-4057qib7 13468 49 t t NNP cord-005453-4057qib7 13468 50 - - HYPH cord-005453-4057qib7 13468 51 AML AML NNP cord-005453-4057qib7 13468 52 ) ) -RRB- cord-005453-4057qib7 13468 53 and and CC cord-005453-4057qib7 13468 54 significant significant JJ cord-005453-4057qib7 13468 55 pre pre JJ cord-005453-4057qib7 13468 56 - - JJ cord-005453-4057qib7 13468 57 alloHCT allohct JJ cord-005453-4057qib7 13468 58 chemotherapy chemotherapy NN cord-005453-4057qib7 13468 59 exposure exposure NN cord-005453-4057qib7 13468 60 ( ( -LRB- cord-005453-4057qib7 13468 61 N=5 N=5 NNP cord-005453-4057qib7 13468 62 ) ) -RRB- cord-005453-4057qib7 13468 63 . . . cord-005453-4057qib7 13469 1 Proportions proportion NNS cord-005453-4057qib7 13469 2 of of IN cord-005453-4057qib7 13469 3 patients patient NNS cord-005453-4057qib7 13469 4 with with IN cord-005453-4057qib7 13469 5 de de NNP cord-005453-4057qib7 13469 6 novo novo NNP cord-005453-4057qib7 13469 7 AML AML NNP cord-005453-4057qib7 13469 8 ( ( -LRB- cord-005453-4057qib7 13469 9 Mel/ Mel/ NNP cord-005453-4057qib7 13469 10 Thio Thio NNP cord-005453-4057qib7 13469 11 , , , cord-005453-4057qib7 13469 12 57 57 CD cord-005453-4057qib7 13469 13 % % NN cord-005453-4057qib7 13469 14 ; ; : cord-005453-4057qib7 13469 15 Bu Bu NNP cord-005453-4057qib7 13469 16 , , , cord-005453-4057qib7 13469 17 78 78 CD cord-005453-4057qib7 13469 18 % % NN cord-005453-4057qib7 13469 19 ) ) -RRB- cord-005453-4057qib7 13469 20 and and CC cord-005453-4057qib7 13469 21 MDR MDR NNP cord-005453-4057qib7 13469 22 - - HYPH cord-005453-4057qib7 13469 23 AML AML NNP cord-005453-4057qib7 13469 24 ( ( -LRB- cord-005453-4057qib7 13469 25 19 19 CD cord-005453-4057qib7 13469 26 % % NN cord-005453-4057qib7 13469 27 and and CC cord-005453-4057qib7 13469 28 21 21 CD cord-005453-4057qib7 13469 29 % % NN cord-005453-4057qib7 13469 30 ) ) -RRB- cord-005453-4057qib7 13469 31 were be VBD cord-005453-4057qib7 13469 32 similar similar JJ cord-005453-4057qib7 13469 33 between between IN cord-005453-4057qib7 13469 34 groups group NNS cord-005453-4057qib7 13469 35 ; ; : cord-005453-4057qib7 13469 36 however however RB cord-005453-4057qib7 13469 37 , , , cord-005453-4057qib7 13469 38 recipients recipient NNS cord-005453-4057qib7 13469 39 of of IN cord-005453-4057qib7 13469 40 Mel Mel NNP cord-005453-4057qib7 13469 41 / / SYM cord-005453-4057qib7 13469 42 Thio Thio NNP cord-005453-4057qib7 13469 43 were be VBD cord-005453-4057qib7 13469 44 more more RBR cord-005453-4057qib7 13469 45 likely likely JJ cord-005453-4057qib7 13469 46 to to TO cord-005453-4057qib7 13469 47 have have VB cord-005453-4057qib7 13469 48 t t VBN cord-005453-4057qib7 13469 49 - - HYPH cord-005453-4057qib7 13469 50 AML AML NNP cord-005453-4057qib7 13469 51 ( ( -LRB- cord-005453-4057qib7 13469 52 24 24 CD cord-005453-4057qib7 13469 53 % % NN cord-005453-4057qib7 13469 54 vs vs IN cord-005453-4057qib7 13469 55 0 0 CD cord-005453-4057qib7 13469 56 % % NN cord-005453-4057qib7 13469 57 ) ) -RRB- cord-005453-4057qib7 13469 58 . . . cord-005453-4057qib7 13470 1 Cytogenetic cytogenetic JJ cord-005453-4057qib7 13470 2 and and CC cord-005453-4057qib7 13470 3 molecular molecular JJ cord-005453-4057qib7 13470 4 risk risk NN cord-005453-4057qib7 13470 5 factors factor NNS cord-005453-4057qib7 13470 6 were be VBD cord-005453-4057qib7 13470 7 similar similar JJ cord-005453-4057qib7 13470 8 between between IN cord-005453-4057qib7 13470 9 groups group NNS cord-005453-4057qib7 13470 10 . . . cord-005453-4057qib7 13471 1 The the DT cord-005453-4057qib7 13471 2 majority majority NN cord-005453-4057qib7 13471 3 of of IN cord-005453-4057qib7 13471 4 patients patient NNS cord-005453-4057qib7 13471 5 were be VBD cord-005453-4057qib7 13471 6 transplanted transplant VBN cord-005453-4057qib7 13471 7 in in IN cord-005453-4057qib7 13471 8 CR1 CR1 NNP cord-005453-4057qib7 13472 1 ( ( -LRB- cord-005453-4057qib7 13472 2 Mel Mel NNP cord-005453-4057qib7 13472 3 / / SYM cord-005453-4057qib7 13472 4 Thio Thio NNP cord-005453-4057qib7 13472 5 , , , cord-005453-4057qib7 13472 6 71 71 CD cord-005453-4057qib7 13472 7 % % NN cord-005453-4057qib7 13472 8 vs vs IN cord-005453-4057qib7 13472 9 Bu Bu NNP cord-005453-4057qib7 13472 10 , , , cord-005453-4057qib7 13472 11 68 68 CD cord-005453-4057qib7 13472 12 % % NN cord-005453-4057qib7 13472 13 ) ) -RRB- cord-005453-4057qib7 13472 14 or or CC cord-005453-4057qib7 13472 15 CR2 CR2 NNP cord-005453-4057qib7 13472 16 ( ( -LRB- cord-005453-4057qib7 13472 17 24 24 CD cord-005453-4057qib7 13472 18 % % NN cord-005453-4057qib7 13472 19 vs vs IN cord-005453-4057qib7 13472 20 38 38 CD cord-005453-4057qib7 13472 21 % % NN cord-005453-4057qib7 13472 22 ) ) -RRB- cord-005453-4057qib7 13472 23 . . . cord-005453-4057qib7 13473 1 More More JJR cord-005453-4057qib7 13473 2 recipients recipient NNS cord-005453-4057qib7 13473 3 of of IN cord-005453-4057qib7 13473 4 Bu Bu NNP cord-005453-4057qib7 13473 5 conditioning conditioning NN cord-005453-4057qib7 13473 6 ( ( -LRB- cord-005453-4057qib7 13473 7 71 71 CD cord-005453-4057qib7 13473 8 % % NN cord-005453-4057qib7 13473 9 vs vs IN cord-005453-4057qib7 13473 10 43 43 CD cord-005453-4057qib7 13473 11 % % NN cord-005453-4057qib7 13473 12 ) ) -RRB- cord-005453-4057qib7 13473 13 were be VBD cord-005453-4057qib7 13473 14 MRD MRD NNP cord-005453-4057qib7 13473 15 - - HYPH cord-005453-4057qib7 13473 16 negative negative JJ cord-005453-4057qib7 13473 17 at at IN cord-005453-4057qib7 13473 18 the the DT cord-005453-4057qib7 13473 19 time time NN cord-005453-4057qib7 13473 20 of of IN cord-005453-4057qib7 13473 21 alloHCT alloHCT NNP cord-005453-4057qib7 13473 22 ; ; : cord-005453-4057qib7 13473 23 both both DT cord-005453-4057qib7 13473 24 groups group NNS cord-005453-4057qib7 13473 25 had have VBD cord-005453-4057qib7 13473 26 comparable comparable JJ cord-005453-4057qib7 13473 27 proportions proportion NNS cord-005453-4057qib7 13473 28 of of IN cord-005453-4057qib7 13473 29 patients patient NNS cord-005453-4057qib7 13473 30 with with IN cord-005453-4057qib7 13473 31 ≥M2 ≥M2 NNP cord-005453-4057qib7 13473 32 marrow marrow NN cord-005453-4057qib7 13473 33 ( ( -LRB- cord-005453-4057qib7 13473 34 ~10 ~10 CD cord-005453-4057qib7 13473 35 % % NN cord-005453-4057qib7 13473 36 ) ) -RRB- cord-005453-4057qib7 13473 37 . . . cord-005453-4057qib7 13474 1 Donor donor NN cord-005453-4057qib7 13474 2 types type NNS cord-005453-4057qib7 13474 3 and and CC cord-005453-4057qib7 13474 4 stem stem NN cord-005453-4057qib7 13474 5 cell cell NN cord-005453-4057qib7 13474 6 sources source NNS cord-005453-4057qib7 13474 7 were be VBD cord-005453-4057qib7 13474 8 similar similar JJ cord-005453-4057qib7 13474 9 between between IN cord-005453-4057qib7 13474 10 groups group NNS cord-005453-4057qib7 13474 11 , , , cord-005453-4057qib7 13474 12 except except IN cord-005453-4057qib7 13474 13 unrelated unrelated JJ cord-005453-4057qib7 13474 14 umbilical umbilical JJ cord-005453-4057qib7 13474 15 cord cord NN cord-005453-4057qib7 13474 16 blood blood NN cord-005453-4057qib7 13474 17 which which WDT cord-005453-4057qib7 13474 18 was be VBD cord-005453-4057qib7 13474 19 more more RBR cord-005453-4057qib7 13474 20 common common JJ cord-005453-4057qib7 13474 21 in in IN cord-005453-4057qib7 13474 22 Bu Bu NNP cord-005453-4057qib7 13474 23 recipients recipient NNS cord-005453-4057qib7 13474 24 ( ( -LRB- cord-005453-4057qib7 13474 25 21 21 CD cord-005453-4057qib7 13474 26 % % NN cord-005453-4057qib7 13474 27 vs vs IN cord-005453-4057qib7 13474 28 10 10 CD cord-005453-4057qib7 13474 29 % % NN cord-005453-4057qib7 13474 30 ) ) -RRB- cord-005453-4057qib7 13474 31 . . . cord-005453-4057qib7 13475 1 There there EX cord-005453-4057qib7 13475 2 were be VBD cord-005453-4057qib7 13475 3 no no DT cord-005453-4057qib7 13475 4 graft graft NN cord-005453-4057qib7 13475 5 failures failure NNS cord-005453-4057qib7 13475 6 in in IN cord-005453-4057qib7 13475 7 Mel Mel NNP cord-005453-4057qib7 13475 8 / / SYM cord-005453-4057qib7 13475 9 Thio Thio NNP cord-005453-4057qib7 13475 10 recipients recipient NNS cord-005453-4057qib7 13475 11 , , , cord-005453-4057qib7 13475 12 compared compare VBN cord-005453-4057qib7 13475 13 to to IN cord-005453-4057qib7 13475 14 14 14 CD cord-005453-4057qib7 13475 15 % % NN cord-005453-4057qib7 13475 16 ( ( -LRB- cord-005453-4057qib7 13475 17 N=4 N=4 NNP cord-005453-4057qib7 13475 18 ) ) -RRB- cord-005453-4057qib7 13475 19 in in IN cord-005453-4057qib7 13475 20 those those DT cord-005453-4057qib7 13475 21 receiving receive VBG cord-005453-4057qib7 13475 22 Bu Bu NNP cord-005453-4057qib7 13475 23 - - HYPH cord-005453-4057qib7 13475 24 based base VBN cord-005453-4057qib7 13475 25 regimens regimen NNS cord-005453-4057qib7 13475 26 . . . cord-005453-4057qib7 13476 1 Engraftment Engraftment NNP cord-005453-4057qib7 13476 2 kinetics kinetic NNS cord-005453-4057qib7 13476 3 and and CC cord-005453-4057qib7 13476 4 immune immune JJ cord-005453-4057qib7 13476 5 reconstitution reconstitution NN cord-005453-4057qib7 13476 6 were be VBD cord-005453-4057qib7 13476 7 similar similar JJ cord-005453-4057qib7 13476 8 . . . cord-005453-4057qib7 13477 1 Overall overall JJ cord-005453-4057qib7 13477 2 acute acute JJ cord-005453-4057qib7 13477 3 and and CC cord-005453-4057qib7 13477 4 chronic chronic JJ cord-005453-4057qib7 13477 5 GVHD GVHD NNP cord-005453-4057qib7 13477 6 incidence incidence NN cord-005453-4057qib7 13477 7 was be VBD cord-005453-4057qib7 13477 8 higher high JJR cord-005453-4057qib7 13477 9 in in IN cord-005453-4057qib7 13477 10 recipients recipient NNS cord-005453-4057qib7 13477 11 of of IN cord-005453-4057qib7 13477 12 Mel/ Mel/ NNP cord-005453-4057qib7 13477 13 Thio Thio NNP cord-005453-4057qib7 13477 14 compared compare VBN cord-005453-4057qib7 13477 15 to to IN cord-005453-4057qib7 13477 16 Bu Bu NNP cord-005453-4057qib7 13477 17 ( ( -LRB- cord-005453-4057qib7 13477 18 39 39 CD cord-005453-4057qib7 13477 19 % % NN cord-005453-4057qib7 13477 20 vs vs IN cord-005453-4057qib7 13477 21 21 21 CD cord-005453-4057qib7 13477 22 % % NN cord-005453-4057qib7 13477 23 , , , cord-005453-4057qib7 13477 24 and and CC cord-005453-4057qib7 13477 25 29 29 CD cord-005453-4057qib7 13477 26 % % NN cord-005453-4057qib7 13477 27 vs vs IN cord-005453-4057qib7 13477 28 18 18 CD cord-005453-4057qib7 13477 29 % % NN cord-005453-4057qib7 13477 30 , , , cord-005453-4057qib7 13477 31 respectively respectively RB cord-005453-4057qib7 13477 32 ) ) -RRB- cord-005453-4057qib7 13477 33 , , , cord-005453-4057qib7 13477 34 but but CC cord-005453-4057qib7 13477 35 rates rate NNS cord-005453-4057qib7 13477 36 of of IN cord-005453-4057qib7 13477 37 grade grade NN cord-005453-4057qib7 13477 38 III III NNP cord-005453-4057qib7 13477 39 - - HYPH cord-005453-4057qib7 13477 40 IV IV NNP cord-005453-4057qib7 13477 41 acute acute JJ cord-005453-4057qib7 13477 42 or or CC cord-005453-4057qib7 13477 43 extensive extensive JJ cord-005453-4057qib7 13477 44 chronic chronic JJ cord-005453-4057qib7 13477 45 GVHD GVHD NNP cord-005453-4057qib7 13477 46 were be VBD cord-005453-4057qib7 13477 47 comparable comparable JJ cord-005453-4057qib7 13477 48 . . . cord-005453-4057qib7 13478 1 VOD VOD NNP cord-005453-4057qib7 13478 2 requiring require VBG cord-005453-4057qib7 13478 3 treatment treatment NN cord-005453-4057qib7 13478 4 was be VBD cord-005453-4057qib7 13478 5 diagnosed diagnose VBN cord-005453-4057qib7 13478 6 in in IN cord-005453-4057qib7 13478 7 6 6 CD cord-005453-4057qib7 13478 8 ( ( -LRB- cord-005453-4057qib7 13478 9 21 21 CD cord-005453-4057qib7 13478 10 % % NN cord-005453-4057qib7 13478 11 ) ) -RRB- cord-005453-4057qib7 13478 12 recipients recipient NNS cord-005453-4057qib7 13478 13 of of IN cord-005453-4057qib7 13478 14 Bu Bu NNP cord-005453-4057qib7 13478 15 conditioning conditioning NN cord-005453-4057qib7 13478 16 and and CC cord-005453-4057qib7 13478 17 no no DT cord-005453-4057qib7 13478 18 Mel Mel NNP cord-005453-4057qib7 13478 19 / / SYM cord-005453-4057qib7 13478 20 Thio Thio NNP cord-005453-4057qib7 13478 21 recipients recipient NNS cord-005453-4057qib7 13478 22 . . . cord-005453-4057qib7 13479 1 Median median JJ cord-005453-4057qib7 13479 2 duration duration NN cord-005453-4057qib7 13479 3 of of IN cord-005453-4057qib7 13479 4 follow follow NN cord-005453-4057qib7 13479 5 - - HYPH cord-005453-4057qib7 13479 6 up up NN cord-005453-4057qib7 13479 7 was be VBD cord-005453-4057qib7 13479 8 30 30 CD cord-005453-4057qib7 13479 9 months month NNS cord-005453-4057qib7 13480 1 ( ( -LRB- cord-005453-4057qib7 13480 2 range range NNP cord-005453-4057qib7 13480 3 2 2 CD cord-005453-4057qib7 13480 4 - - SYM cord-005453-4057qib7 13480 5 70 70 CD cord-005453-4057qib7 13480 6 ) ) -RRB- cord-005453-4057qib7 13480 7 in in IN cord-005453-4057qib7 13480 8 the the DT cord-005453-4057qib7 13480 9 Mel Mel NNP cord-005453-4057qib7 13480 10 / / SYM cord-005453-4057qib7 13480 11 Thio Thio NNP cord-005453-4057qib7 13480 12 group group NN cord-005453-4057qib7 13480 13 , , , cord-005453-4057qib7 13480 14 and and CC cord-005453-4057qib7 13480 15 18 18 CD cord-005453-4057qib7 13480 16 months month NNS cord-005453-4057qib7 13480 17 ( ( -LRB- cord-005453-4057qib7 13480 18 range range VBP cord-005453-4057qib7 13480 19 1 1 CD cord-005453-4057qib7 13480 20 - - SYM cord-005453-4057qib7 13480 21 121 121 CD cord-005453-4057qib7 13480 22 ) ) -RRB- cord-005453-4057qib7 13480 23 in in IN cord-005453-4057qib7 13480 24 the the DT cord-005453-4057qib7 13480 25 Bu Bu NNP cord-005453-4057qib7 13480 26 group group NN cord-005453-4057qib7 13480 27 . . . cord-005453-4057qib7 13481 1 Transplantrelated transplantrelate VBN cord-005453-4057qib7 13481 2 mortality mortality NN cord-005453-4057qib7 13481 3 ( ( -LRB- cord-005453-4057qib7 13481 4 TRM TRM NNP cord-005453-4057qib7 13481 5 ) ) -RRB- cord-005453-4057qib7 13481 6 was be VBD cord-005453-4057qib7 13481 7 similar similar JJ cord-005453-4057qib7 13481 8 in in IN cord-005453-4057qib7 13481 9 both both DT cord-005453-4057qib7 13481 10 groups group NNS cord-005453-4057qib7 13481 11 ( ( -LRB- cord-005453-4057qib7 13481 12 1 1 CD cord-005453-4057qib7 13481 13 patient patient NN cord-005453-4057qib7 13481 14 ) ) -RRB- cord-005453-4057qib7 13481 15 , , , cord-005453-4057qib7 13481 16 occurring occur VBG cord-005453-4057qib7 13481 17 before before IN cord-005453-4057qib7 13481 18 day day NN cord-005453-4057qib7 13481 19 100 100 CD cord-005453-4057qib7 13481 20 . . . cord-005453-4057qib7 13482 1 Relapse relapse NN cord-005453-4057qib7 13482 2 incidence incidence NN cord-005453-4057qib7 13482 3 was be VBD cord-005453-4057qib7 13482 4 comparable comparable JJ cord-005453-4057qib7 13482 5 ( ( -LRB- cord-005453-4057qib7 13482 6 Mel Mel NNP cord-005453-4057qib7 13482 7 / / SYM cord-005453-4057qib7 13482 8 Thio Thio NNP cord-005453-4057qib7 13482 9 , , , cord-005453-4057qib7 13482 10 29 29 CD cord-005453-4057qib7 13482 11 % % NN cord-005453-4057qib7 13482 12 vs vs IN cord-005453-4057qib7 13482 13 Bu Bu NNP cord-005453-4057qib7 13482 14 , , , cord-005453-4057qib7 13482 15 32 32 CD cord-005453-4057qib7 13482 16 % % NN cord-005453-4057qib7 13482 17 ) ) -RRB- cord-005453-4057qib7 13482 18 ; ; : cord-005453-4057qib7 13482 19 however however RB cord-005453-4057qib7 13482 20 , , , cord-005453-4057qib7 13482 21 relapse relapse NN cord-005453-4057qib7 13482 22 occurred occur VBD cord-005453-4057qib7 13482 23 at at IN cord-005453-4057qib7 13482 24 a a DT cord-005453-4057qib7 13482 25 later later JJ cord-005453-4057qib7 13482 26 time time NN cord-005453-4057qib7 13482 27 in in IN cord-005453-4057qib7 13482 28 Mel Mel NNP cord-005453-4057qib7 13482 29 / / SYM cord-005453-4057qib7 13482 30 Thio Thio NNP cord-005453-4057qib7 13482 31 recipients recipient NNS cord-005453-4057qib7 13482 32 ( ( -LRB- cord-005453-4057qib7 13483 1 median median NNP cord-005453-4057qib7 13483 2 d d NNP cord-005453-4057qib7 13483 3 +396 +396 NNP cord-005453-4057qib7 13483 4 vs vs IN cord-005453-4057qib7 13483 5 d+137 d+137 CD cord-005453-4057qib7 13483 6 ) ) -RRB- cord-005453-4057qib7 13483 7 . . . cord-005453-4057qib7 13484 1 Overall overall JJ cord-005453-4057qib7 13484 2 survival survival NN cord-005453-4057qib7 13484 3 at at IN cord-005453-4057qib7 13484 4 1 1 CD cord-005453-4057qib7 13484 5 and and CC cord-005453-4057qib7 13484 6 3 3 CD cord-005453-4057qib7 13484 7 years year NNS cord-005453-4057qib7 13484 8 was be VBD cord-005453-4057qib7 13484 9 superior superior JJ cord-005453-4057qib7 13484 10 in in IN cord-005453-4057qib7 13484 11 Mel Mel NNP cord-005453-4057qib7 13484 12 / / SYM cord-005453-4057qib7 13484 13 Thio Thio NNP cord-005453-4057qib7 13484 14 recipients recipient NNS cord-005453-4057qib7 13484 15 ( ( -LRB- cord-005453-4057qib7 13484 16 95 95 CD cord-005453-4057qib7 13484 17 % % NN cord-005453-4057qib7 13484 18 vs vs IN cord-005453-4057qib7 13484 19 74 74 CD cord-005453-4057qib7 13484 20 % % NN cord-005453-4057qib7 13484 21 , , , cord-005453-4057qib7 13484 22 and and CC cord-005453-4057qib7 13484 23 75 75 CD cord-005453-4057qib7 13484 24 % % NN cord-005453-4057qib7 13484 25 vs vs IN cord-005453-4057qib7 13484 26 50 50 CD cord-005453-4057qib7 13484 27 % % NN cord-005453-4057qib7 13484 28 , , , cord-005453-4057qib7 13484 29 respectively respectively RB cord-005453-4057qib7 13484 30 ) ) -RRB- cord-005453-4057qib7 13484 31 . . . cord-005453-4057qib7 13485 1 Conclusions conclusion NNS cord-005453-4057qib7 13485 2 : : : cord-005453-4057qib7 13486 1 In in IN cord-005453-4057qib7 13486 2 our -PRON- PRP$ cord-005453-4057qib7 13486 3 single single JJ cord-005453-4057qib7 13486 4 institution institution NN cord-005453-4057qib7 13486 5 experience experience NN cord-005453-4057qib7 13486 6 , , , cord-005453-4057qib7 13486 7 use use NN cord-005453-4057qib7 13486 8 of of IN cord-005453-4057qib7 13486 9 a a DT cord-005453-4057qib7 13486 10 melphalan melphalan NNP cord-005453-4057qib7 13486 11 / / SYM cord-005453-4057qib7 13486 12 thiotepa thiotepa NNP cord-005453-4057qib7 13486 13 - - HYPH cord-005453-4057qib7 13486 14 based base VBN cord-005453-4057qib7 13486 15 RIC RIC NNP cord-005453-4057qib7 13486 16 regimen regimen NN cord-005453-4057qib7 13486 17 was be VBD cord-005453-4057qib7 13486 18 associated associate VBN cord-005453-4057qib7 13486 19 with with IN cord-005453-4057qib7 13486 20 similar similar JJ cord-005453-4057qib7 13486 21 outcomes outcome NNS cord-005453-4057qib7 13486 22 compared compare VBN cord-005453-4057qib7 13486 23 to to IN cord-005453-4057qib7 13486 24 full full JJ cord-005453-4057qib7 13486 25 - - HYPH cord-005453-4057qib7 13486 26 intensity intensity NN cord-005453-4057qib7 13486 27 Bu Bu NNP cord-005453-4057qib7 13486 28 - - HYPH cord-005453-4057qib7 13486 29 based base VBN cord-005453-4057qib7 13486 30 conditioning conditioning NN cord-005453-4057qib7 13486 31 , , , cord-005453-4057qib7 13486 32 despite despite IN cord-005453-4057qib7 13486 33 higher high JJR cord-005453-4057qib7 13486 34 risk risk NN cord-005453-4057qib7 13486 35 patient patient NN cord-005453-4057qib7 13486 36 and and CC cord-005453-4057qib7 13486 37 disease disease NN cord-005453-4057qib7 13486 38 characteristics characteristic NNS cord-005453-4057qib7 13486 39 . . . cord-005453-4057qib7 13487 1 The the DT cord-005453-4057qib7 13487 2 majority majority NN cord-005453-4057qib7 13487 3 of of IN cord-005453-4057qib7 13487 4 recipients recipient NNS cord-005453-4057qib7 13487 5 of of IN cord-005453-4057qib7 13487 6 Mel Mel NNP cord-005453-4057qib7 13487 7 / / SYM cord-005453-4057qib7 13487 8 Thio Thio NNP cord-005453-4057qib7 13487 9 conditioning conditioning NN cord-005453-4057qib7 13487 10 had have VBD cord-005453-4057qib7 13487 11 significant significant JJ cord-005453-4057qib7 13487 12 pre pre JJ cord-005453-4057qib7 13487 13 - - JJ cord-005453-4057qib7 13487 14 transplant transplant JJ cord-005453-4057qib7 13487 15 comorbidities comorbiditie NNS cord-005453-4057qib7 13487 16 , , , cord-005453-4057qib7 13487 17 which which WDT cord-005453-4057qib7 13487 18 did do VBD cord-005453-4057qib7 13487 19 not not RB cord-005453-4057qib7 13487 20 translate translate VB cord-005453-4057qib7 13487 21 into into IN cord-005453-4057qib7 13487 22 higher high JJR cord-005453-4057qib7 13487 23 TRM TRM NNP cord-005453-4057qib7 13487 24 . . . cord-005453-4057qib7 13488 1 While while IN cord-005453-4057qib7 13488 2 Mel Mel NNP cord-005453-4057qib7 13488 3 / / SYM cord-005453-4057qib7 13488 4 Thio Thio NNP cord-005453-4057qib7 13488 5 recipients recipient NNS cord-005453-4057qib7 13488 6 had have VBD cord-005453-4057qib7 13488 7 less less RBR cord-005453-4057qib7 13488 8 optimal optimal JJ cord-005453-4057qib7 13488 9 leukemia leukemia NN cord-005453-4057qib7 13488 10 control control NN cord-005453-4057qib7 13488 11 at at IN cord-005453-4057qib7 13488 12 the the DT cord-005453-4057qib7 13488 13 time time NN cord-005453-4057qib7 13488 14 of of IN cord-005453-4057qib7 13488 15 transplant transplant NN cord-005453-4057qib7 13488 16 and and CC cord-005453-4057qib7 13488 17 high high JJ cord-005453-4057qib7 13488 18 - - HYPH cord-005453-4057qib7 13488 19 risk risk NN cord-005453-4057qib7 13488 20 leukemia leukemia NN cord-005453-4057qib7 13488 21 features feature NNS cord-005453-4057qib7 13488 22 ( ( -LRB- cord-005453-4057qib7 13488 23 e.g. e.g. IN cord-005453-4057qib7 13488 24 t t NNP cord-005453-4057qib7 13488 25 - - HYPH cord-005453-4057qib7 13488 26 AML AML NNP cord-005453-4057qib7 13488 27 ) ) -RRB- cord-005453-4057qib7 13488 28 , , , cord-005453-4057qib7 13488 29 relapse relapse NN cord-005453-4057qib7 13488 30 was be VBD cord-005453-4057qib7 13488 31 similar similar JJ cord-005453-4057qib7 13488 32 between between IN cord-005453-4057qib7 13488 33 groups group NNS cord-005453-4057qib7 13488 34 , , , cord-005453-4057qib7 13488 35 occurring occur VBG cord-005453-4057qib7 13488 36 later later RB cord-005453-4057qib7 13488 37 in in IN cord-005453-4057qib7 13488 38 Mel/ Mel/ NNP cord-005453-4057qib7 13488 39 Thio Thio NNP cord-005453-4057qib7 13488 40 recipients recipient NNS cord-005453-4057qib7 13488 41 , , , cord-005453-4057qib7 13488 42 which which WDT cord-005453-4057qib7 13488 43 may may MD cord-005453-4057qib7 13488 44 have have VB cord-005453-4057qib7 13488 45 contributed contribute VBN cord-005453-4057qib7 13488 46 to to IN cord-005453-4057qib7 13488 47 better well JJR cord-005453-4057qib7 13488 48 overall overall JJ cord-005453-4057qib7 13488 49 survival survival NN cord-005453-4057qib7 13488 50 . . . cord-005453-4057qib7 13489 1 Disclosure disclosure NN cord-005453-4057qib7 13489 2 : : : cord-005453-4057qib7 13489 3 Nothing nothing NN cord-005453-4057qib7 13489 4 to to TO cord-005453-4057qib7 13489 5 disclose disclose VB cord-005453-4057qib7 13489 6 Methods method NNS cord-005453-4057qib7 13489 7 : : : cord-005453-4057qib7 13489 8 Pubertal pubertal JJ cord-005453-4057qib7 13489 9 development development NN cord-005453-4057qib7 13489 10 and and CC cord-005453-4057qib7 13489 11 biological biological JJ cord-005453-4057qib7 13489 12 gonadal gonadal JJ cord-005453-4057qib7 13489 13 parameters parameter NNS cord-005453-4057qib7 13489 14 were be VBD cord-005453-4057qib7 13489 15 assessed assess VBN cord-005453-4057qib7 13489 16 in in IN cord-005453-4057qib7 13489 17 a a DT cord-005453-4057qib7 13489 18 retrospective retrospective JJ cord-005453-4057qib7 13489 19 monocentric monocentric JJ cord-005453-4057qib7 13489 20 cohort cohort NN cord-005453-4057qib7 13489 21 of of IN cord-005453-4057qib7 13489 22 pre pre JJ cord-005453-4057qib7 13489 23 - - JJ cord-005453-4057qib7 13489 24 pubertal pubertal JJ cord-005453-4057qib7 13489 25 patients patient NNS cord-005453-4057qib7 13489 26 who who WP cord-005453-4057qib7 13489 27 underwent undergo VBD cord-005453-4057qib7 13489 28 HSCT HSCT NNP cord-005453-4057qib7 13489 29 after after IN cord-005453-4057qib7 13489 30 myeloablative myeloablative NNP cord-005453-4057qib7 13489 31 conditioning conditioning NN cord-005453-4057qib7 13489 32 with with IN cord-005453-4057qib7 13489 33 Total total JJ cord-005453-4057qib7 13489 34 Body Body NNP cord-005453-4057qib7 13489 35 Irradiation Irradiation NNP cord-005453-4057qib7 13489 36 ( ( -LRB- cord-005453-4057qib7 13489 37 TBI TBI NNP cord-005453-4057qib7 13489 38 ) ) -RRB- cord-005453-4057qib7 13489 39 or or CC cord-005453-4057qib7 13489 40 Busulfan Busulfan NNP cord-005453-4057qib7 13489 41 between between IN cord-005453-4057qib7 13489 42 1981 1981 CD cord-005453-4057qib7 13489 43 and and CC cord-005453-4057qib7 13489 44 2017 2017 CD cord-005453-4057qib7 13489 45 . . . cord-005453-4057qib7 13490 1 Results result NNS cord-005453-4057qib7 13490 2 : : : cord-005453-4057qib7 13491 1 Seventy seventy CD cord-005453-4057qib7 13491 2 - - HYPH cord-005453-4057qib7 13491 3 four four CD cord-005453-4057qib7 13491 4 patients patient NNS cord-005453-4057qib7 13491 5 ( ( -LRB- cord-005453-4057qib7 13491 6 28 28 CD cord-005453-4057qib7 13491 7 girls girl NNS cord-005453-4057qib7 13491 8 and and CC cord-005453-4057qib7 13491 9 46 46 CD cord-005453-4057qib7 13491 10 boys boy NNS cord-005453-4057qib7 13491 11 ) ) -RRB- cord-005453-4057qib7 13491 12 were be VBD cord-005453-4057qib7 13491 13 included include VBN cord-005453-4057qib7 13491 14 . . . cord-005453-4057qib7 13492 1 No no DT cord-005453-4057qib7 13492 2 spontaneous spontaneous JJ cord-005453-4057qib7 13492 3 pubertal pubertal JJ cord-005453-4057qib7 13492 4 development development NN cord-005453-4057qib7 13492 5 was be VBD cord-005453-4057qib7 13492 6 found find VBN cord-005453-4057qib7 13492 7 in in IN cord-005453-4057qib7 13492 8 50 50 CD cord-005453-4057qib7 13492 9 % % NN cord-005453-4057qib7 13492 10 of of IN cord-005453-4057qib7 13492 11 girls girl NNS cord-005453-4057qib7 13492 12 and and CC cord-005453-4057qib7 13492 13 10 10 CD cord-005453-4057qib7 13492 14 % % NN cord-005453-4057qib7 13492 15 of of IN cord-005453-4057qib7 13492 16 boys boy NNS cord-005453-4057qib7 13492 17 ( ( -LRB- cord-005453-4057qib7 13492 18 p p NN cord-005453-4057qib7 13492 19 < < XX cord-005453-4057qib7 13492 20 0.001 0.001 CD cord-005453-4057qib7 13492 21 ) ) -RRB- cord-005453-4057qib7 13492 22 and and CC cord-005453-4057qib7 13492 23 delayed delay VBD cord-005453-4057qib7 13492 24 puberty puberty NN cord-005453-4057qib7 13492 25 or or CC cord-005453-4057qib7 13492 26 no no DT cord-005453-4057qib7 13492 27 spontaneous spontaneous JJ cord-005453-4057qib7 13492 28 pubertal pubertal JJ cord-005453-4057qib7 13492 29 development development NN cord-005453-4057qib7 13492 30 was be VBD cord-005453-4057qib7 13492 31 found find VBN cord-005453-4057qib7 13492 32 in in IN cord-005453-4057qib7 13492 33 57 57 CD cord-005453-4057qib7 13492 34 % % NN cord-005453-4057qib7 13492 35 of of IN cord-005453-4057qib7 13492 36 girls girl NNS cord-005453-4057qib7 13492 37 and and CC cord-005453-4057qib7 13492 38 24 24 CD cord-005453-4057qib7 13492 39 % % NN cord-005453-4057qib7 13492 40 of of IN cord-005453-4057qib7 13492 41 boys boy NNS cord-005453-4057qib7 13492 42 ( ( -LRB- cord-005453-4057qib7 13492 43 p=0.009 p=0.009 NN cord-005453-4057qib7 13492 44 ) ) -RRB- cord-005453-4057qib7 13492 45 . . . cord-005453-4057qib7 13493 1 Hormone hormone NN cord-005453-4057qib7 13493 2 replacement replacement NN cord-005453-4057qib7 13493 3 therapy therapy NN cord-005453-4057qib7 13493 4 was be VBD cord-005453-4057qib7 13493 5 used use VBN cord-005453-4057qib7 13493 6 in in IN cord-005453-4057qib7 13493 7 82 82 CD cord-005453-4057qib7 13493 8 % % NN cord-005453-4057qib7 13493 9 of of IN cord-005453-4057qib7 13493 10 girls girl NNS cord-005453-4057qib7 13493 11 and and CC cord-005453-4057qib7 13493 12 24 24 CD cord-005453-4057qib7 13493 13 % % NN cord-005453-4057qib7 13493 14 of of IN cord-005453-4057qib7 13493 15 boys boy NNS cord-005453-4057qib7 13493 16 ( ( -LRB- cord-005453-4057qib7 13493 17 p p NN cord-005453-4057qib7 13493 18 < < XX cord-005453-4057qib7 13493 19 0.001 0.001 CD cord-005453-4057qib7 13493 20 ) ) -RRB- cord-005453-4057qib7 13493 21 . . . cord-005453-4057qib7 13494 1 In in IN cord-005453-4057qib7 13494 2 univariate univariate JJ cord-005453-4057qib7 13494 3 analysis analysis NN cord-005453-4057qib7 13494 4 , , , cord-005453-4057qib7 13494 5 TBI TBI NNP cord-005453-4057qib7 13494 6 conditioning conditioning NN cord-005453-4057qib7 13494 7 ( ( -LRB- cord-005453-4057qib7 13494 8 p=0.05 p=0.05 NNP cord-005453-4057qib7 13494 9 ) ) -RRB- cord-005453-4057qib7 13494 10 , , , cord-005453-4057qib7 13494 11 female female JJ cord-005453-4057qib7 13494 12 sex sex NN cord-005453-4057qib7 13494 13 ( ( -LRB- cord-005453-4057qib7 13494 14 p p NN cord-005453-4057qib7 13494 15 < < XX cord-005453-4057qib7 13494 16 0.001 0.001 CD cord-005453-4057qib7 13494 17 ) ) -RRB- cord-005453-4057qib7 13494 18 , , , cord-005453-4057qib7 13494 19 acute acute JJ cord-005453-4057qib7 13494 20 GVHD GVHD NNP cord-005453-4057qib7 13494 21 ( ( -LRB- cord-005453-4057qib7 13494 22 p=0.05 p=0.05 NNP cord-005453-4057qib7 13494 23 ) ) -RRB- cord-005453-4057qib7 13494 24 , , , cord-005453-4057qib7 13494 25 extensive extensive JJ cord-005453-4057qib7 13494 26 chronic chronic JJ cord-005453-4057qib7 13494 27 GVHD GVHD NNP cord-005453-4057qib7 13494 28 ( ( -LRB- cord-005453-4057qib7 13494 29 p=0.021 p=0.021 NNP cord-005453-4057qib7 13494 30 ) ) -RRB- cord-005453-4057qib7 13494 31 , , , cord-005453-4057qib7 13494 32 steroid steroid NN cord-005453-4057qib7 13494 33 treatment treatment NN cord-005453-4057qib7 13494 34 > > XX cord-005453-4057qib7 13494 35 6 6 CD cord-005453-4057qib7 13494 36 months month NNS cord-005453-4057qib7 13494 37 ( ( -LRB- cord-005453-4057qib7 13494 38 p=0.016 p=0.016 RB cord-005453-4057qib7 13494 39 ) ) -RRB- cord-005453-4057qib7 13494 40 , , , cord-005453-4057qib7 13494 41 and and CC cord-005453-4057qib7 13494 42 malignant malignant JJ cord-005453-4057qib7 13494 43 diseases disease NNS cord-005453-4057qib7 13494 44 ( ( -LRB- cord-005453-4057qib7 13494 45 p=0.016 p=0.016 RB cord-005453-4057qib7 13494 46 ) ) -RRB- cord-005453-4057qib7 13494 47 were be VBD cord-005453-4057qib7 13494 48 associated associate VBN cord-005453-4057qib7 13494 49 with with IN cord-005453-4057qib7 13494 50 no no DT cord-005453-4057qib7 13494 51 spontaneous spontaneous JJ cord-005453-4057qib7 13494 52 pubertal pubertal JJ cord-005453-4057qib7 13494 53 development development NN cord-005453-4057qib7 13494 54 , , , cord-005453-4057qib7 13494 55 whereas whereas IN cord-005453-4057qib7 13494 56 TBI TBI NNP cord-005453-4057qib7 13494 57 conditioning conditioning NN cord-005453-4057qib7 13494 58 ( ( -LRB- cord-005453-4057qib7 13494 59 p=0.003 p=0.003 NNP cord-005453-4057qib7 13494 60 ) ) -RRB- cord-005453-4057qib7 13494 61 and and CC cord-005453-4057qib7 13494 62 extensive extensive JJ cord-005453-4057qib7 13494 63 chronic chronic JJ cord-005453-4057qib7 13494 64 GVHD GVHD NNP cord-005453-4057qib7 13494 65 ( ( -LRB- cord-005453-4057qib7 13494 66 p=0.005 p=0.005 NNP cord-005453-4057qib7 13494 67 ) ) -RRB- cord-005453-4057qib7 13494 68 were be VBD cord-005453-4057qib7 13494 69 associated associate VBN cord-005453-4057qib7 13494 70 with with IN cord-005453-4057qib7 13494 71 delayed delay VBN cord-005453-4057qib7 13494 72 puberty puberty NN cord-005453-4057qib7 13494 73 . . . cord-005453-4057qib7 13495 1 In in IN cord-005453-4057qib7 13495 2 multivariate multivariate JJ cord-005453-4057qib7 13495 3 analysis analysis NN cord-005453-4057qib7 13495 4 , , , cord-005453-4057qib7 13495 5 factors factor NNS cord-005453-4057qib7 13495 6 independently independently RB cord-005453-4057qib7 13495 7 associated associate VBN cord-005453-4057qib7 13495 8 with with IN cord-005453-4057qib7 13495 9 no no DT cord-005453-4057qib7 13495 10 spontaneous spontaneous JJ cord-005453-4057qib7 13495 11 puberty puberty NN cord-005453-4057qib7 13495 12 onset onset NN cord-005453-4057qib7 13495 13 were be VBD cord-005453-4057qib7 13495 14 female female JJ cord-005453-4057qib7 13495 15 sex sex NN cord-005453-4057qib7 13495 16 ( ( -LRB- cord-005453-4057qib7 13495 17 p=0.001 p=0.001 NNP cord-005453-4057qib7 13495 18 ) ) -RRB- cord-005453-4057qib7 13495 19 and and CC cord-005453-4057qib7 13495 20 age age NN cord-005453-4057qib7 13495 21 > > XX cord-005453-4057qib7 13495 22 10 10 CD cord-005453-4057qib7 13495 23 years year NNS cord-005453-4057qib7 13495 24 ( ( -LRB- cord-005453-4057qib7 13495 25 p=0.033 p=0.033 NNP cord-005453-4057qib7 13495 26 ) ) -RRB- cord-005453-4057qib7 13495 27 . . . cord-005453-4057qib7 13496 1 Factors factor NNS cord-005453-4057qib7 13496 2 independently independently RB cord-005453-4057qib7 13496 3 associated associate VBD cord-005453-4057qib7 13496 4 with with IN cord-005453-4057qib7 13496 5 delayed delay VBN cord-005453-4057qib7 13496 6 puberty puberty NN cord-005453-4057qib7 13496 7 were be VBD cord-005453-4057qib7 13496 8 extensive extensive JJ cord-005453-4057qib7 13496 9 chronic chronic JJ cord-005453-4057qib7 13496 10 GVHD GVHD NNP cord-005453-4057qib7 13496 11 ( ( -LRB- cord-005453-4057qib7 13496 12 p=0.041 p=0.041 NNP cord-005453-4057qib7 13496 13 ) ) -RRB- cord-005453-4057qib7 13496 14 and and CC cord-005453-4057qib7 13496 15 age age NN cord-005453-4057qib7 13496 16 > > XX cord-005453-4057qib7 13496 17 10 10 CD cord-005453-4057qib7 13496 18 years year NNS cord-005453-4057qib7 13496 19 ( ( -LRB- cord-005453-4057qib7 13496 20 p=0.031 p=0.031 NNP cord-005453-4057qib7 13496 21 ) ) -RRB- cord-005453-4057qib7 13496 22 . . . cord-005453-4057qib7 13497 1 TBI TBI NNP cord-005453-4057qib7 13497 2 was be VBD cord-005453-4057qib7 13497 3 not not RB cord-005453-4057qib7 13497 4 an an DT cord-005453-4057qib7 13497 5 independent independent JJ cord-005453-4057qib7 13497 6 risk risk NN cord-005453-4057qib7 13497 7 factor factor NN cord-005453-4057qib7 13497 8 for for IN cord-005453-4057qib7 13497 9 pubertal pubertal JJ cord-005453-4057qib7 13497 10 complications complication NNS cord-005453-4057qib7 13497 11 . . . cord-005453-4057qib7 13498 1 Conclusions conclusion NNS cord-005453-4057qib7 13498 2 : : : cord-005453-4057qib7 13499 1 This this DT cord-005453-4057qib7 13499 2 study study NN cord-005453-4057qib7 13499 3 confirms confirm VBZ cord-005453-4057qib7 13499 4 the the DT cord-005453-4057qib7 13499 5 toxicity toxicity NN cord-005453-4057qib7 13499 6 of of IN cord-005453-4057qib7 13499 7 myeloablative myeloablative JJ cord-005453-4057qib7 13499 8 conditioning conditioning NN cord-005453-4057qib7 13499 9 on on IN cord-005453-4057qib7 13499 10 pubertal pubertal JJ cord-005453-4057qib7 13499 11 development development NN cord-005453-4057qib7 13499 12 and and CC cord-005453-4057qib7 13499 13 the the DT cord-005453-4057qib7 13499 14 role role NN cord-005453-4057qib7 13499 15 of of IN cord-005453-4057qib7 13499 16 older old JJR cord-005453-4057qib7 13499 17 age age NN cord-005453-4057qib7 13499 18 and and CC cord-005453-4057qib7 13499 19 female female JJ cord-005453-4057qib7 13499 20 sex sex NN cord-005453-4057qib7 13499 21 in in IN cord-005453-4057qib7 13499 22 increased increase VBN cord-005453-4057qib7 13499 23 pubertal pubertal JJ cord-005453-4057qib7 13499 24 issues issue NNS cord-005453-4057qib7 13499 25 , , , cord-005453-4057qib7 13499 26 and and CC cord-005453-4057qib7 13499 27 suggests suggest VBZ cord-005453-4057qib7 13499 28 a a DT cord-005453-4057qib7 13499 29 possible possible JJ cord-005453-4057qib7 13499 30 role role NN cord-005453-4057qib7 13499 31 of of IN cord-005453-4057qib7 13499 32 GVHD GVHD NNP cord-005453-4057qib7 13499 33 in in IN cord-005453-4057qib7 13499 34 delayed delay VBN cord-005453-4057qib7 13499 35 puberty puberty NN cord-005453-4057qib7 13499 36 . . . cord-005453-4057qib7 13500 1 Disclosure disclosure NN cord-005453-4057qib7 13500 2 : : : cord-005453-4057qib7 13500 3 Nothing nothing NN cord-005453-4057qib7 13500 4 to to TO cord-005453-4057qib7 13500 5 declare declare VB cord-005453-4057qib7 13500 6 P613 P613 VBN cord-005453-4057qib7 13500 7 Abstract Abstract NNP cord-005453-4057qib7 13500 8 already already RB cord-005453-4057qib7 13500 9 published publish VBN cord-005453-4057qib7 13500 10 . . . cord-005453-4057qib7 13501 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 13501 2 elastase elastase NN cord-005453-4057qib7 13501 3 activity activity NN cord-005453-4057qib7 13501 4 may may MD cord-005453-4057qib7 13501 5 serve serve VB cord-005453-4057qib7 13501 6 as as IN cord-005453-4057qib7 13501 7 a a DT cord-005453-4057qib7 13501 8 marker marker NN cord-005453-4057qib7 13501 9 for for IN cord-005453-4057qib7 13501 10 neutrophil neutrophil NN cord-005453-4057qib7 13501 11 extracellular extracellular JJ cord-005453-4057qib7 13501 12 traps trap NNS cord-005453-4057qib7 13501 13 formation formation NN cord-005453-4057qib7 13501 14 following follow VBG cord-005453-4057qib7 13501 15 stem stem NN cord-005453-4057qib7 13501 16 cell cell NN cord-005453-4057qib7 13501 17 transplantation transplantation NN cord-005453-4057qib7 13501 18 Ronit Ronit NNP cord-005453-4057qib7 13501 19 Elhasid Elhasid NNP cord-005453-4057qib7 13501 20 1 1 CD cord-005453-4057qib7 13501 21 , , , cord-005453-4057qib7 13501 22 Sivan Sivan NNP cord-005453-4057qib7 13501 23 Berger Berger NNP cord-005453-4057qib7 13501 24 - - HYPH cord-005453-4057qib7 13501 25 Achituv Achituv NNP cord-005453-4057qib7 13501 26 1 1 CD cord-005453-4057qib7 13501 27 , , , cord-005453-4057qib7 13501 28 Hila Hila NNP cord-005453-4057qib7 13501 29 Rosenfeld Rosenfeld NNP cord-005453-4057qib7 13501 30 - - HYPH cord-005453-4057qib7 13501 31 Keidar Keidar NNP cord-005453-4057qib7 13501 32 1 1 CD cord-005453-4057qib7 13501 33 , , , cord-005453-4057qib7 13501 34 Szilvia Szilvia NNP cord-005453-4057qib7 13501 35 Baron Baron NNP cord-005453-4057qib7 13501 36 1 1 CD cord-005453-4057qib7 13501 37 1 1 CD cord-005453-4057qib7 13501 38 Tel Tel NNP cord-005453-4057qib7 13501 39 Aviv Aviv NNP cord-005453-4057qib7 13501 40 Sourasky Sourasky NNP cord-005453-4057qib7 13501 41 Medical Medical NNP cord-005453-4057qib7 13501 42 Center Center NNP cord-005453-4057qib7 13502 1 -Tel -Tel VBG cord-005453-4057qib7 13502 2 Aviv Aviv NNP cord-005453-4057qib7 13502 3 University University NNP cord-005453-4057qib7 13502 4 , , , cord-005453-4057qib7 13502 5 Tel Tel NNP cord-005453-4057qib7 13502 6 Aviv Aviv NNP cord-005453-4057qib7 13503 1 , , , cord-005453-4057qib7 13503 2 Israel Israel NNP cord-005453-4057qib7 13503 3 Background Background NNP cord-005453-4057qib7 13503 4 : : : cord-005453-4057qib7 13504 1 Post post JJ cord-005453-4057qib7 13504 2 - - JJ cord-005453-4057qib7 13504 3 transplant transplant JJ cord-005453-4057qib7 13504 4 Infections infection NNS cord-005453-4057qib7 13504 5 rise rise VBP cord-005453-4057qib7 13504 6 dramatically dramatically RB cord-005453-4057qib7 13504 7 in in IN cord-005453-4057qib7 13504 8 patients patient NNS cord-005453-4057qib7 13504 9 with with IN cord-005453-4057qib7 13504 10 quantitative quantitative JJ cord-005453-4057qib7 13504 11 or or CC cord-005453-4057qib7 13504 12 qualitative qualitative JJ cord-005453-4057qib7 13504 13 neutrophil neutrophil NN cord-005453-4057qib7 13504 14 defects defect NNS cord-005453-4057qib7 13504 15 and and CC cord-005453-4057qib7 13504 16 constitute constitute VBP cord-005453-4057qib7 13504 17 a a DT cord-005453-4057qib7 13504 18 major major JJ cord-005453-4057qib7 13504 19 source source NN cord-005453-4057qib7 13504 20 of of IN cord-005453-4057qib7 13504 21 morbidity morbidity NN cord-005453-4057qib7 13504 22 and and CC cord-005453-4057qib7 13504 23 mortality mortality NN cord-005453-4057qib7 13504 24 following follow VBG cord-005453-4057qib7 13504 25 hematopoietic hematopoietic JJ cord-005453-4057qib7 13504 26 stem stem NN cord-005453-4057qib7 13504 27 cell cell NN cord-005453-4057qib7 13504 28 transplantation transplantation NN cord-005453-4057qib7 13504 29 ( ( -LRB- cord-005453-4057qib7 13504 30 HSCT HSCT NNP cord-005453-4057qib7 13504 31 ) ) -RRB- cord-005453-4057qib7 13504 32 . . . cord-005453-4057qib7 13505 1 Neutrophils neutrophil NNS cord-005453-4057qib7 13505 2 protect protect VBP cord-005453-4057qib7 13505 3 the the DT cord-005453-4057qib7 13505 4 host host NN cord-005453-4057qib7 13505 5 from from IN cord-005453-4057qib7 13505 6 microorganisms microorganism NNS cord-005453-4057qib7 13505 7 via via IN cord-005453-4057qib7 13505 8 multiple multiple JJ cord-005453-4057qib7 13505 9 processes process NNS cord-005453-4057qib7 13505 10 including include VBG cord-005453-4057qib7 13505 11 phagocytosis phagocytosis NN cord-005453-4057qib7 13505 12 and and CC cord-005453-4057qib7 13505 13 formation formation NN cord-005453-4057qib7 13505 14 of of IN cord-005453-4057qib7 13505 15 neutrophil neutrophil NN cord-005453-4057qib7 13505 16 extracellular extracellular JJ cord-005453-4057qib7 13505 17 traps trap NNS cord-005453-4057qib7 13505 18 ( ( -LRB- cord-005453-4057qib7 13505 19 NETs nets NN cord-005453-4057qib7 13505 20 ) ) -RRB- cord-005453-4057qib7 13505 21 . . . cord-005453-4057qib7 13506 1 Although although IN cord-005453-4057qib7 13506 2 reactive reactive JJ cord-005453-4057qib7 13506 3 oxygen oxygen NN cord-005453-4057qib7 13506 4 species specie NNS cord-005453-4057qib7 13506 5 ( ( -LRB- cord-005453-4057qib7 13506 6 ROS ROS NNP cord-005453-4057qib7 13506 7 ) ) -RRB- cord-005453-4057qib7 13506 8 production production NN cord-005453-4057qib7 13506 9 seems seem VBZ cord-005453-4057qib7 13506 10 to to TO cord-005453-4057qib7 13506 11 be be VB cord-005453-4057qib7 13506 12 essential essential JJ cord-005453-4057qib7 13506 13 for for IN cord-005453-4057qib7 13506 14 NETs net NNS cord-005453-4057qib7 13506 15 formation formation NN cord-005453-4057qib7 13506 16 , , , cord-005453-4057qib7 13506 17 the the DT cord-005453-4057qib7 13506 18 key key JJ cord-005453-4057qib7 13506 19 enzymes enzyme NNS cord-005453-4057qib7 13506 20 of of IN cord-005453-4057qib7 13506 21 the the DT cord-005453-4057qib7 13506 22 process process NN cord-005453-4057qib7 13506 23 are be VBP cord-005453-4057qib7 13506 24 neutrophil neutrophil NN cord-005453-4057qib7 13506 25 elastase elastase NN cord-005453-4057qib7 13506 26 ( ( -LRB- cord-005453-4057qib7 13506 27 NE NE NNP cord-005453-4057qib7 13506 28 ) ) -RRB- cord-005453-4057qib7 13506 29 and and CC cord-005453-4057qib7 13506 30 myeloperoxidase myeloperoxidase NNP cord-005453-4057qib7 13506 31 ( ( -LRB- cord-005453-4057qib7 13506 32 MPO MPO NNP cord-005453-4057qib7 13506 33 ) ) -RRB- cord-005453-4057qib7 13506 34 . . . cord-005453-4057qib7 13507 1 Methods method NNS cord-005453-4057qib7 13507 2 : : : cord-005453-4057qib7 13507 3 NE NE NNP cord-005453-4057qib7 13507 4 and and CC cord-005453-4057qib7 13507 5 MPO MPO NNP cord-005453-4057qib7 13507 6 activity activity NN cord-005453-4057qib7 13507 7 as as RB cord-005453-4057qib7 13507 8 well well RB cord-005453-4057qib7 13507 9 as as IN cord-005453-4057qib7 13508 1 NETs NETs NNP cord-005453-4057qib7 13508 2 formation formation NN cord-005453-4057qib7 13508 3 were be VBD cord-005453-4057qib7 13508 4 investigated investigate VBN cord-005453-4057qib7 13508 5 following follow VBG cord-005453-4057qib7 13508 6 HSCT HSCT NNP cord-005453-4057qib7 13508 7 in in IN cord-005453-4057qib7 13508 8 11 11 CD cord-005453-4057qib7 13508 9 patients patient NNS cord-005453-4057qib7 13508 10 at at IN cord-005453-4057qib7 13508 11 week week NN cord-005453-4057qib7 13508 12 1 1 CD cord-005453-4057qib7 13508 13 to to IN cord-005453-4057qib7 13508 14 6 6 CD cord-005453-4057qib7 13508 15 and and CC cord-005453-4057qib7 13508 16 30 30 CD cord-005453-4057qib7 13508 17 after after IN cord-005453-4057qib7 13508 18 neutrophil neutrophil NN cord-005453-4057qib7 13508 19 engraftment engraftment NN cord-005453-4057qib7 13508 20 . . . cord-005453-4057qib7 13509 1 Neutrophils neutrophil NNS cord-005453-4057qib7 13509 2 were be VBD cord-005453-4057qib7 13509 3 isolated isolate VBN cord-005453-4057qib7 13509 4 using use VBG cord-005453-4057qib7 13509 5 EasySep EasySep NNP cord-005453-4057qib7 13509 6 Direct Direct NNP cord-005453-4057qib7 13509 7 Human Human NNP cord-005453-4057qib7 13509 8 Neutrophil Neutrophil NNP cord-005453-4057qib7 13509 9 isolation isolation NN cord-005453-4057qib7 13509 10 kit kit NN cord-005453-4057qib7 13509 11 ( ( -LRB- cord-005453-4057qib7 13509 12 StemCell StemCell NNP cord-005453-4057qib7 13509 13 Technologies Technologies NNPS cord-005453-4057qib7 13509 14 Inc. Inc. NNP cord-005453-4057qib7 13509 15 ) ) -RRB- cord-005453-4057qib7 13509 16 by by IN cord-005453-4057qib7 13509 17 immunomagnetic immunomagnetic JJ cord-005453-4057qib7 13509 18 negative negative JJ cord-005453-4057qib7 13509 19 selection selection NN cord-005453-4057qib7 13509 20 . . . cord-005453-4057qib7 13510 1 Enzymatic enzymatic JJ cord-005453-4057qib7 13510 2 activity activity NN cord-005453-4057qib7 13510 3 of of IN cord-005453-4057qib7 13510 4 NE NE NNP cord-005453-4057qib7 13510 5 and and CC cord-005453-4057qib7 13510 6 MPO MPO NNP cord-005453-4057qib7 13510 7 were be VBD cord-005453-4057qib7 13510 8 measured measure VBN cord-005453-4057qib7 13510 9 using use VBG cord-005453-4057qib7 13510 10 colorimetric colorimetric JJ cord-005453-4057qib7 13510 11 assays assay NNS cord-005453-4057qib7 13510 12 . . . cord-005453-4057qib7 13511 1 NETs NETs NNP cord-005453-4057qib7 13511 2 formation formation NN cord-005453-4057qib7 13511 3 of of IN cord-005453-4057qib7 13511 4 phorbol phorbol NNP cord-005453-4057qib7 13511 5 12-myristate 12-myristate CD cord-005453-4057qib7 13511 6 13-acetate 13-acetate CD cord-005453-4057qib7 13511 7 ( ( -LRB- cord-005453-4057qib7 13511 8 PMA)activated pma)activated JJ cord-005453-4057qib7 13511 9 neutrophils neutrophil NNS cord-005453-4057qib7 13511 10 was be VBD cord-005453-4057qib7 13511 11 investigated investigate VBN cord-005453-4057qib7 13511 12 by by IN cord-005453-4057qib7 13511 13 confocal confocal JJ cord-005453-4057qib7 13511 14 fluorescence fluorescence NN cord-005453-4057qib7 13511 15 microscopy microscopy NN cord-005453-4057qib7 13511 16 . . . cord-005453-4057qib7 13512 1 All all DT cord-005453-4057qib7 13512 2 results result NNS cord-005453-4057qib7 13512 3 were be VBD cord-005453-4057qib7 13512 4 compared compare VBN cord-005453-4057qib7 13512 5 to to IN cord-005453-4057qib7 13512 6 those those DT cord-005453-4057qib7 13512 7 of of IN cord-005453-4057qib7 13512 8 healthy healthy JJ cord-005453-4057qib7 13512 9 volunteers volunteer NNS cord-005453-4057qib7 13512 10 . . . cord-005453-4057qib7 13513 1 Statistical statistical JJ cord-005453-4057qib7 13513 2 significance significance NN cord-005453-4057qib7 13513 3 was be VBD cord-005453-4057qib7 13513 4 calculated calculate VBN cord-005453-4057qib7 13513 5 using use VBG cord-005453-4057qib7 13513 6 one one CD cord-005453-4057qib7 13513 7 way way NN cord-005453-4057qib7 13513 8 - - HYPH cord-005453-4057qib7 13513 9 ANOVA anova NN cord-005453-4057qib7 13513 10 with with IN cord-005453-4057qib7 13513 11 Bonferroni Bonferroni NNP cord-005453-4057qib7 13513 12 post post VB cord-005453-4057qib7 13513 13 hoc hoc JJ cord-005453-4057qib7 13513 14 test test NN cord-005453-4057qib7 13513 15 . . . cord-005453-4057qib7 13514 1 Results result NNS cord-005453-4057qib7 13514 2 : : : cord-005453-4057qib7 13514 3 11 11 CD cord-005453-4057qib7 13514 4 patients patient NNS cord-005453-4057qib7 13514 5 ( ( -LRB- cord-005453-4057qib7 13514 6 median median JJ cord-005453-4057qib7 13514 7 age age NN cord-005453-4057qib7 13514 8 of of IN cord-005453-4057qib7 13514 9 6.8 6.8 CD cord-005453-4057qib7 13514 10 years year NNS cord-005453-4057qib7 13514 11 [ [ -LRB- cord-005453-4057qib7 13514 12 range range NN cord-005453-4057qib7 13514 13 2 2 CD cord-005453-4057qib7 13514 14 - - SYM cord-005453-4057qib7 13514 15 22 22 CD cord-005453-4057qib7 13514 16 years year NNS cord-005453-4057qib7 13514 17 ] ] -RRB- cord-005453-4057qib7 13514 18 ) ) -RRB- cord-005453-4057qib7 13514 19 were be VBD cord-005453-4057qib7 13514 20 investigated investigate VBN cord-005453-4057qib7 13514 21 , , , cord-005453-4057qib7 13514 22 6 6 CD cord-005453-4057qib7 13514 23 following follow VBG cord-005453-4057qib7 13514 24 allogeneic allogeneic NN cord-005453-4057qib7 13514 25 HSCT HSCT NNP cord-005453-4057qib7 13514 26 ( ( -LRB- cord-005453-4057qib7 13514 27 2 2 CD cord-005453-4057qib7 13514 28 acute acute JJ cord-005453-4057qib7 13514 29 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13514 30 leukemia leukemia NN cord-005453-4057qib7 13514 31 , , , cord-005453-4057qib7 13514 32 1 1 CD cord-005453-4057qib7 13514 33 acute acute JJ cord-005453-4057qib7 13514 34 myeloblastic myeloblastic JJ cord-005453-4057qib7 13514 35 leukemia leukemia NN cord-005453-4057qib7 13514 36 , , , cord-005453-4057qib7 13514 37 2 2 CD cord-005453-4057qib7 13514 38 epidermolysis epidermolysis NN cord-005453-4057qib7 13514 39 bullosa bullosa NNP cord-005453-4057qib7 13514 40 , , , cord-005453-4057qib7 13514 41 1 1 CD cord-005453-4057qib7 13514 42 rhabdomyosarcoma rhabdomyosarcoma NNP cord-005453-4057qib7 13514 43 ) ) -RRB- cord-005453-4057qib7 13514 44 and and CC cord-005453-4057qib7 13514 45 5 5 CD cord-005453-4057qib7 13514 46 following follow VBG cord-005453-4057qib7 13514 47 autologous autologous JJ cord-005453-4057qib7 13514 48 HSCT HSCT NNP cord-005453-4057qib7 13514 49 ( ( -LRB- cord-005453-4057qib7 13514 50 4 4 CD cord-005453-4057qib7 13514 51 Ewing Ewing NNP cord-005453-4057qib7 13514 52 sarcoma sarcoma NN cord-005453-4057qib7 13514 53 , , , cord-005453-4057qib7 13515 1 1 1 CD cord-005453-4057qib7 13515 2 desmoplastic desmoplastic JJ cord-005453-4057qib7 13515 3 small small JJ cord-005453-4057qib7 13515 4 round round JJ cord-005453-4057qib7 13515 5 cell cell NN cord-005453-4057qib7 13515 6 tumor tumor NN cord-005453-4057qib7 13515 7 ) ) -RRB- cord-005453-4057qib7 13515 8 . . . cord-005453-4057qib7 13516 1 All all DT cord-005453-4057qib7 13516 2 patients patient NNS cord-005453-4057qib7 13516 3 experienced experience VBD cord-005453-4057qib7 13516 4 fever fever NN cord-005453-4057qib7 13516 5 and and CC cord-005453-4057qib7 13516 6 neutropenia neutropenia NN cord-005453-4057qib7 13516 7 . . . cord-005453-4057qib7 13517 1 At at IN cord-005453-4057qib7 13517 2 engraftment engraftment NN cord-005453-4057qib7 13517 3 , , , cord-005453-4057qib7 13517 4 average average JJ cord-005453-4057qib7 13517 5 NE NE NNP cord-005453-4057qib7 13517 6 activity activity NN cord-005453-4057qib7 13517 7 was be VBD cord-005453-4057qib7 13517 8 significantly significantly RB cord-005453-4057qib7 13517 9 decreased decrease VBN cord-005453-4057qib7 13517 10 compared compare VBN cord-005453-4057qib7 13517 11 to to IN cord-005453-4057qib7 13517 12 the the DT cord-005453-4057qib7 13517 13 average average JJ cord-005453-4057qib7 13517 14 value value NN cord-005453-4057qib7 13517 15 of of IN cord-005453-4057qib7 13517 16 50 50 CD cord-005453-4057qib7 13517 17 healthy healthy JJ cord-005453-4057qib7 13517 18 individuals individual NNS cord-005453-4057qib7 13517 19 . . . cord-005453-4057qib7 13518 1 NE NE NNP cord-005453-4057qib7 13518 2 activity activity NN cord-005453-4057qib7 13518 3 improved improve VBD cord-005453-4057qib7 13518 4 week week NN cord-005453-4057qib7 13518 5 by by IN cord-005453-4057qib7 13518 6 week week NN cord-005453-4057qib7 13518 7 in in IN cord-005453-4057qib7 13518 8 patients patient NNS cord-005453-4057qib7 13518 9 , , , cord-005453-4057qib7 13518 10 reached reach VBD cord-005453-4057qib7 13518 11 the the DT cord-005453-4057qib7 13518 12 lower low JJR cord-005453-4057qib7 13518 13 reference reference NN cord-005453-4057qib7 13518 14 range range NN cord-005453-4057qib7 13518 15 at at IN cord-005453-4057qib7 13518 16 4 4 CD cord-005453-4057qib7 13518 17 weeks week NNS cord-005453-4057qib7 13518 18 following follow VBG cord-005453-4057qib7 13518 19 transplantation transplantation NN cord-005453-4057qib7 13518 20 ( ( -LRB- cord-005453-4057qib7 13518 21 Fig Fig NNP cord-005453-4057qib7 13518 22 . . . cord-005453-4057qib7 13518 23 1A 1a NN cord-005453-4057qib7 13518 24 ) ) -RRB- cord-005453-4057qib7 13518 25 and and CC cord-005453-4057qib7 13518 26 continued continue VBD cord-005453-4057qib7 13518 27 to to TO cord-005453-4057qib7 13518 28 increase increase VB cord-005453-4057qib7 13518 29 . . . cord-005453-4057qib7 13519 1 The the DT cord-005453-4057qib7 13519 2 enzymatic enzymatic JJ cord-005453-4057qib7 13519 3 activity activity NN cord-005453-4057qib7 13519 4 of of IN cord-005453-4057qib7 13519 5 MPO MPO NNP cord-005453-4057qib7 13519 6 was be VBD cord-005453-4057qib7 13519 7 comparable comparable JJ cord-005453-4057qib7 13519 8 to to IN cord-005453-4057qib7 13519 9 the the DT cord-005453-4057qib7 13519 10 average average JJ cord-005453-4057qib7 13519 11 value value NN cord-005453-4057qib7 13519 12 of of IN cord-005453-4057qib7 13519 13 50 50 CD cord-005453-4057qib7 13519 14 healthy healthy JJ cord-005453-4057qib7 13519 15 individuals individual NNS cord-005453-4057qib7 13519 16 ( ( -LRB- cord-005453-4057qib7 13519 17 Fig fig NN cord-005453-4057qib7 13519 18 . . . cord-005453-4057qib7 13519 19 1B 1b LS cord-005453-4057qib7 13519 20 ) ) -RRB- cord-005453-4057qib7 13519 21 and and CC cord-005453-4057qib7 13519 22 showed show VBD cord-005453-4057qib7 13519 23 no no DT cord-005453-4057qib7 13519 24 significant significant JJ cord-005453-4057qib7 13519 25 difference difference NN cord-005453-4057qib7 13519 26 between between IN cord-005453-4057qib7 13519 27 the the DT cord-005453-4057qib7 13519 28 distinct distinct JJ cord-005453-4057qib7 13519 29 time time NN cord-005453-4057qib7 13519 30 points point NNS cord-005453-4057qib7 13519 31 . . . cord-005453-4057qib7 13520 1 At at IN cord-005453-4057qib7 13520 2 neutrophil neutrophil NN cord-005453-4057qib7 13520 3 engraftment engraftment NN cord-005453-4057qib7 13520 4 , , , cord-005453-4057qib7 13520 5 NETs NETs NNP cord-005453-4057qib7 13520 6 formation formation NN cord-005453-4057qib7 13520 7 was be VBD cord-005453-4057qib7 13520 8 absent absent JJ cord-005453-4057qib7 13520 9 and and CC cord-005453-4057qib7 13520 10 comparable comparable JJ cord-005453-4057qib7 13520 11 to to IN cord-005453-4057qib7 13520 12 those those DT cord-005453-4057qib7 13520 13 of of IN cord-005453-4057qib7 13520 14 non non JJ cord-005453-4057qib7 13520 15 - - JJ cord-005453-4057qib7 13520 16 activated activate VBN cord-005453-4057qib7 13520 17 neutrophils neutrophil NNS cord-005453-4057qib7 13520 18 ( ( -LRB- cord-005453-4057qib7 13520 19 Fig Fig NNP cord-005453-4057qib7 13520 20 . . . cord-005453-4057qib7 13520 21 1C 1C NNP cord-005453-4057qib7 13520 22 ) ) -RRB- cord-005453-4057qib7 13520 23 . . . cord-005453-4057qib7 13521 1 Although although IN cord-005453-4057qib7 13521 2 NETs net NNS cord-005453-4057qib7 13521 3 formation formation NN cord-005453-4057qib7 13521 4 increased increase VBN cord-005453-4057qib7 13521 5 week week NN cord-005453-4057qib7 13521 6 by by IN cord-005453-4057qib7 13521 7 week week NN cord-005453-4057qib7 13521 8 , , , cord-005453-4057qib7 13521 9 it -PRON- PRP cord-005453-4057qib7 13521 10 did do VBD cord-005453-4057qib7 13521 11 not not RB cord-005453-4057qib7 13521 12 reach reach VB cord-005453-4057qib7 13521 13 the the DT cord-005453-4057qib7 13521 14 average average NN cord-005453-4057qib7 13521 15 of of IN cord-005453-4057qib7 13521 16 7 7 CD cord-005453-4057qib7 13521 17 normal normal JJ cord-005453-4057qib7 13521 18 controls control NNS cord-005453-4057qib7 13521 19 during during IN cord-005453-4057qib7 13521 20 the the DT cord-005453-4057qib7 13521 21 monitored monitor VBN cord-005453-4057qib7 13521 22 time time NN cord-005453-4057qib7 13521 23 period period NN cord-005453-4057qib7 13521 24 . . . cord-005453-4057qib7 13522 1 Also also RB cord-005453-4057qib7 13522 2 linear linear JJ cord-005453-4057qib7 13522 3 correlation correlation NN cord-005453-4057qib7 13522 4 between between IN cord-005453-4057qib7 13522 5 NE NE NNP cord-005453-4057qib7 13522 6 activity activity NN cord-005453-4057qib7 13522 7 and and CC cord-005453-4057qib7 13522 8 NETs nets NN cord-005453-4057qib7 13522 9 formation formation NN cord-005453-4057qib7 13523 1 ( ( -LRB- cord-005453-4057qib7 13523 2 R r NN cord-005453-4057qib7 13523 3 2 2 CD cord-005453-4057qib7 13523 4 = = SYM cord-005453-4057qib7 13523 5 0.978 0.978 CD cord-005453-4057qib7 13523 6 ) ) -RRB- cord-005453-4057qib7 13523 7 was be VBD cord-005453-4057qib7 13523 8 demonstrated demonstrate VBN cord-005453-4057qib7 13523 9 . . . cord-005453-4057qib7 13524 1 Conclusions conclusion NNS cord-005453-4057qib7 13524 2 : : : cord-005453-4057qib7 13525 1 Impaired impaired JJ cord-005453-4057qib7 13525 2 NE NE NNP cord-005453-4057qib7 13525 3 activity activity NN cord-005453-4057qib7 13525 4 following follow VBG cord-005453-4057qib7 13525 5 HSCT HSCT NNP cord-005453-4057qib7 13525 6 corresponds correspond VBZ cord-005453-4057qib7 13525 7 to to IN cord-005453-4057qib7 13525 8 decreased decrease VBN cord-005453-4057qib7 13525 9 NETs nets NN cord-005453-4057qib7 13525 10 formation formation NN cord-005453-4057qib7 13525 11 and and CC cord-005453-4057qib7 13525 12 could could MD cord-005453-4057qib7 13525 13 serve serve VB cord-005453-4057qib7 13525 14 as as IN cord-005453-4057qib7 13525 15 a a DT cord-005453-4057qib7 13525 16 marker marker NN cord-005453-4057qib7 13525 17 for for IN cord-005453-4057qib7 13525 18 NETosis NETosis NNP cord-005453-4057qib7 13525 19 . . . cord-005453-4057qib7 13526 1 Strategies strategy NNS cord-005453-4057qib7 13526 2 to to TO cord-005453-4057qib7 13526 3 accelerate accelerate VB cord-005453-4057qib7 13526 4 the the DT cord-005453-4057qib7 13526 5 recovery recovery NN cord-005453-4057qib7 13526 6 of of IN cord-005453-4057qib7 13526 7 NE NE NNP cord-005453-4057qib7 13526 8 function function NN cord-005453-4057qib7 13526 9 post post NN cord-005453-4057qib7 13526 10 transplantation transplantation NN cord-005453-4057qib7 13526 11 might may MD cord-005453-4057qib7 13526 12 improve improve VB cord-005453-4057qib7 13526 13 NETs net NNS cord-005453-4057qib7 13526 14 formation formation NN cord-005453-4057qib7 13526 15 and and CC cord-005453-4057qib7 13526 16 thereby thereby RB cord-005453-4057qib7 13526 17 induce induce VB cord-005453-4057qib7 13526 18 better well JJR cord-005453-4057qib7 13526 19 infection infection NN cord-005453-4057qib7 13526 20 control control NN cord-005453-4057qib7 13526 21 . . . cord-005453-4057qib7 13527 1 A a LS cord-005453-4057qib7 13527 2 ) ) -RRB- cord-005453-4057qib7 13528 1 The the DT cord-005453-4057qib7 13528 2 average average NN cord-005453-4057qib7 13528 3 of of IN cord-005453-4057qib7 13528 4 NE NE NNP cord-005453-4057qib7 13528 5 activity activity NN cord-005453-4057qib7 13528 6 ( ( -LRB- cord-005453-4057qib7 13528 7 N=11 N=11 NNP cord-005453-4057qib7 13528 8 ) ) -RRB- cord-005453-4057qib7 13528 9 during during IN cord-005453-4057qib7 13528 10 30 30 CD cord-005453-4057qib7 13528 11 weeks week NNS cord-005453-4057qib7 13528 12 following follow VBG cord-005453-4057qib7 13528 13 HSCT HSCT NNP cord-005453-4057qib7 13528 14 . . . cord-005453-4057qib7 13529 1 Reference reference NN cord-005453-4057qib7 13529 2 range range NN cord-005453-4057qib7 13529 3 was be VBD cord-005453-4057qib7 13529 4 measured measure VBN cord-005453-4057qib7 13529 5 and and CC cord-005453-4057qib7 13529 6 calculated calculate VBN cord-005453-4057qib7 13529 7 from from IN cord-005453-4057qib7 13529 8 measurements measurement NNS cord-005453-4057qib7 13529 9 of of IN cord-005453-4057qib7 13529 10 50 50 CD cord-005453-4057qib7 13529 11 healthy healthy JJ cord-005453-4057qib7 13529 12 volunteers volunteer NNS cord-005453-4057qib7 13529 13 using use VBG cord-005453-4057qib7 13529 14 . . . cord-005453-4057qib7 13530 1 B b NN cord-005453-4057qib7 13530 2 ) ) -RRB- cord-005453-4057qib7 13531 1 The the DT cord-005453-4057qib7 13531 2 average average NN cord-005453-4057qib7 13531 3 of of IN cord-005453-4057qib7 13531 4 MPO MPO NNP cord-005453-4057qib7 13531 5 activity activity NN cord-005453-4057qib7 13531 6 ( ( -LRB- cord-005453-4057qib7 13531 7 N=11 N=11 NNP cord-005453-4057qib7 13531 8 ) ) -RRB- cord-005453-4057qib7 13531 9 during during IN cord-005453-4057qib7 13531 10 30 30 CD cord-005453-4057qib7 13531 11 weeks week NNS cord-005453-4057qib7 13531 12 following follow VBG cord-005453-4057qib7 13531 13 HSCT HSCT NNP cord-005453-4057qib7 13531 14 . . . cord-005453-4057qib7 13532 1 Reference reference NN cord-005453-4057qib7 13532 2 ranges range NNS cord-005453-4057qib7 13532 3 were be VBD cord-005453-4057qib7 13532 4 measured measure VBN cord-005453-4057qib7 13532 5 and and CC cord-005453-4057qib7 13532 6 calculated calculate VBN cord-005453-4057qib7 13532 7 from from IN cord-005453-4057qib7 13532 8 measurements measurement NNS cord-005453-4057qib7 13532 9 of of IN cord-005453-4057qib7 13532 10 50 50 CD cord-005453-4057qib7 13532 11 healthy healthy JJ cord-005453-4057qib7 13532 12 volunteers volunteer NNS cord-005453-4057qib7 13532 13 using use VBG cord-005453-4057qib7 13532 14 the the DT cord-005453-4057qib7 13532 15 quartile quartile JJ cord-005453-4057qib7 13532 16 method method NN cord-005453-4057qib7 13532 17 . . . cord-005453-4057qib7 13533 1 C C NNP cord-005453-4057qib7 13533 2 ) ) -RRB- cord-005453-4057qib7 13534 1 The the DT cord-005453-4057qib7 13534 2 average average NN cord-005453-4057qib7 13534 3 of of IN cord-005453-4057qib7 13534 4 NETosis netosis NN cord-005453-4057qib7 13534 5 activity activity NN cord-005453-4057qib7 13534 6 after after IN cord-005453-4057qib7 13534 7 100 100 CD cord-005453-4057qib7 13534 8 nM nm CD cord-005453-4057qib7 13534 9 PMA PMA NNP cord-005453-4057qib7 13534 10 activation activation NN cord-005453-4057qib7 13534 11 for for IN cord-005453-4057qib7 13534 12 3h 3h CD cord-005453-4057qib7 13534 13 ( ( -LRB- cord-005453-4057qib7 13534 14 N=11 N=11 NNP cord-005453-4057qib7 13534 15 Background Background NNP cord-005453-4057qib7 13534 16 : : : cord-005453-4057qib7 13535 1 To to TO cord-005453-4057qib7 13535 2 have have VB cord-005453-4057qib7 13535 3 a a DT cord-005453-4057qib7 13535 4 better well JJR cord-005453-4057qib7 13535 5 understanding understanding NN cord-005453-4057qib7 13535 6 of of IN cord-005453-4057qib7 13535 7 incidence incidence NN cord-005453-4057qib7 13535 8 , , , cord-005453-4057qib7 13535 9 treatment treatment NN cord-005453-4057qib7 13535 10 , , , cord-005453-4057qib7 13535 11 outcome outcome NN cord-005453-4057qib7 13535 12 and and CC cord-005453-4057qib7 13535 13 risk risk NN cord-005453-4057qib7 13535 14 factors factor NNS cord-005453-4057qib7 13535 15 of of IN cord-005453-4057qib7 13535 16 immune immune JJ cord-005453-4057qib7 13535 17 cytopenia cytopenia NNS cord-005453-4057qib7 13535 18 in in IN cord-005453-4057qib7 13535 19 children child NNS cord-005453-4057qib7 13535 20 after after IN cord-005453-4057qib7 13535 21 allogeneic allogeneic NN cord-005453-4057qib7 13535 22 HSCT HSCT NNP cord-005453-4057qib7 13535 23 . . . cord-005453-4057qib7 13536 1 Methods method NNS cord-005453-4057qib7 13536 2 : : : cord-005453-4057qib7 13536 3 Between between IN cord-005453-4057qib7 13536 4 January January NNP cord-005453-4057qib7 13536 5 2010 2010 CD cord-005453-4057qib7 13536 6 and and CC cord-005453-4057qib7 13536 7 September September NNP cord-005453-4057qib7 13536 8 2018 2018 CD cord-005453-4057qib7 13536 9 , , , cord-005453-4057qib7 13536 10 105 105 CD cord-005453-4057qib7 13536 11 pediatric pediatric JJ cord-005453-4057qib7 13536 12 allogeneic allogeneic NN cord-005453-4057qib7 13536 13 HSCT HSCT NNP cord-005453-4057qib7 13536 14 have have VBP cord-005453-4057qib7 13536 15 been be VBN cord-005453-4057qib7 13536 16 performed perform VBN cord-005453-4057qib7 13536 17 in in IN cord-005453-4057qib7 13536 18 99 99 CD cord-005453-4057qib7 13536 19 patients patient NNS cord-005453-4057qib7 13536 20 at at IN cord-005453-4057qib7 13536 21 the the DT cord-005453-4057qib7 13536 22 Ghent Ghent NNP cord-005453-4057qib7 13536 23 University University NNP cord-005453-4057qib7 13536 24 Hospital Hospital NNP cord-005453-4057qib7 13536 25 ( ( -LRB- cord-005453-4057qib7 13536 26 Ghent Ghent NNP cord-005453-4057qib7 13536 27 , , , cord-005453-4057qib7 13536 28 Belgium Belgium NNP cord-005453-4057qib7 13536 29 ) ) -RRB- cord-005453-4057qib7 13536 30 . . . cord-005453-4057qib7 13537 1 Autoimmune autoimmune JJ cord-005453-4057qib7 13537 2 hemolytic hemolytic JJ cord-005453-4057qib7 13537 3 anemia anemia NN cord-005453-4057qib7 13537 4 was be VBD cord-005453-4057qib7 13537 5 defined define VBN cord-005453-4057qib7 13537 6 by by IN cord-005453-4057qib7 13537 7 a a DT cord-005453-4057qib7 13537 8 positive positive JJ cord-005453-4057qib7 13537 9 direct direct JJ cord-005453-4057qib7 13537 10 agglutinin agglutinin NNS cord-005453-4057qib7 13537 11 test test NN cord-005453-4057qib7 13537 12 ( ( -LRB- cord-005453-4057qib7 13537 13 DAT DAT NNP cord-005453-4057qib7 13537 14 ) ) -RRB- cord-005453-4057qib7 13537 15 . . . cord-005453-4057qib7 13538 1 DAT DAT NNP cord-005453-4057qib7 13538 2 was be VBD cord-005453-4057qib7 13538 3 performed perform VBN cord-005453-4057qib7 13538 4 at at IN cord-005453-4057qib7 13538 5 moment moment NN cord-005453-4057qib7 13538 6 of of IN cord-005453-4057qib7 13538 7 engraftment engraftment NN cord-005453-4057qib7 13538 8 and and CC cord-005453-4057qib7 13538 9 in in IN cord-005453-4057qib7 13538 10 case case NN cord-005453-4057qib7 13538 11 of of IN cord-005453-4057qib7 13538 12 hemolysis hemolysis NN cord-005453-4057qib7 13538 13 or or CC cord-005453-4057qib7 13538 14 unexplained unexplained JJ cord-005453-4057qib7 13538 15 anemia anemia NN cord-005453-4057qib7 13538 16 . . . cord-005453-4057qib7 13539 1 Platelets platelets NN cord-005453-4057qib7 13539 2 antibodies antibody NNS cord-005453-4057qib7 13539 3 were be VBD cord-005453-4057qib7 13539 4 evaluated evaluate VBN cord-005453-4057qib7 13539 5 in in IN cord-005453-4057qib7 13539 6 case case NN cord-005453-4057qib7 13539 7 of of IN cord-005453-4057qib7 13539 8 no no DT cord-005453-4057qib7 13539 9 otherwise otherwise RB cord-005453-4057qib7 13539 10 explained explain VBN cord-005453-4057qib7 13539 11 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 13539 12 . . . cord-005453-4057qib7 13540 1 Results result NNS cord-005453-4057qib7 13540 2 : : : cord-005453-4057qib7 13541 1 The the DT cord-005453-4057qib7 13541 2 cumulative cumulative JJ cord-005453-4057qib7 13541 3 incidence incidence NN cord-005453-4057qib7 13541 4 of of IN cord-005453-4057qib7 13541 5 post post FW cord-005453-4057qib7 13541 6 allo allo FW cord-005453-4057qib7 13541 7 SCT SCT NNP cord-005453-4057qib7 13541 8 autoimmune autoimmune JJ cord-005453-4057qib7 13541 9 cytopenia cytopenia NNP cord-005453-4057qib7 13541 10 is be VBZ cord-005453-4057qib7 13541 11 9.5 9.5 CD cord-005453-4057qib7 13541 12 % % NN cord-005453-4057qib7 13541 13 ( ( -LRB- cord-005453-4057qib7 13541 14 10/105 10/105 CD cord-005453-4057qib7 13541 15 ) ) -RRB- cord-005453-4057qib7 13541 16 . . . cord-005453-4057qib7 13542 1 In in IN cord-005453-4057qib7 13542 2 9 9 CD cord-005453-4057qib7 13542 3 cases case NNS cord-005453-4057qib7 13542 4 there there EX cord-005453-4057qib7 13542 5 were be VBD cord-005453-4057qib7 13542 6 positive positive JJ cord-005453-4057qib7 13542 7 antibodies antibody NNS cord-005453-4057qib7 13542 8 against against IN cord-005453-4057qib7 13542 9 red red JJ cord-005453-4057qib7 13542 10 blood blood NN cord-005453-4057qib7 13542 11 cells cell NNS cord-005453-4057qib7 13542 12 , , , cord-005453-4057qib7 13542 13 and and CC cord-005453-4057qib7 13542 14 one one CD cord-005453-4057qib7 13542 15 patient patient NN cord-005453-4057qib7 13542 16 against against IN cord-005453-4057qib7 13542 17 had have VBD cord-005453-4057qib7 13542 18 antibodies antibody NNS cord-005453-4057qib7 13542 19 against against IN cord-005453-4057qib7 13542 20 platelets platelet NNS cord-005453-4057qib7 13542 21 . . . cord-005453-4057qib7 13543 1 Of of IN cord-005453-4057qib7 13543 2 these these DT cord-005453-4057qib7 13543 3 10 10 CD cord-005453-4057qib7 13543 4 cases case NNS cord-005453-4057qib7 13543 5 , , , cord-005453-4057qib7 13543 6 only only RB cord-005453-4057qib7 13543 7 4 4 CD cord-005453-4057qib7 13543 8 ( ( -LRB- cord-005453-4057qib7 13543 9 3.8 3.8 CD cord-005453-4057qib7 13543 10 % % NN cord-005453-4057qib7 13543 11 ) ) -RRB- cord-005453-4057qib7 13543 12 were be VBD cord-005453-4057qib7 13543 13 clinically clinically RB cord-005453-4057qib7 13543 14 relevant relevant JJ cord-005453-4057qib7 13543 15 and and CC cord-005453-4057qib7 13543 16 needed needed JJ cord-005453-4057qib7 13543 17 treatment treatment NN cord-005453-4057qib7 13543 18 . . . cord-005453-4057qib7 13544 1 The the DT cord-005453-4057qib7 13544 2 median median JJ cord-005453-4057qib7 13544 3 observation observation NN cord-005453-4057qib7 13544 4 period period NN cord-005453-4057qib7 13544 5 post post NN cord-005453-4057qib7 13544 6 SCT SCT NNP cord-005453-4057qib7 13544 7 for for IN cord-005453-4057qib7 13544 8 the the DT cord-005453-4057qib7 13544 9 whole whole JJ cord-005453-4057qib7 13544 10 cohort cohort NN cord-005453-4057qib7 13544 11 was be VBD cord-005453-4057qib7 13544 12 36 36 CD cord-005453-4057qib7 13544 13 months month NNS cord-005453-4057qib7 13544 14 ( ( -LRB- cord-005453-4057qib7 13544 15 3 3 CD cord-005453-4057qib7 13544 16 -105 -105 NN cord-005453-4057qib7 13544 17 ) ) -RRB- cord-005453-4057qib7 13544 18 . . . cord-005453-4057qib7 13545 1 The the DT cord-005453-4057qib7 13545 2 clinically clinically RB cord-005453-4057qib7 13545 3 significant significant JJ cord-005453-4057qib7 13545 4 immune immune JJ cord-005453-4057qib7 13545 5 cytopenia cytopenia NNS cord-005453-4057qib7 13545 6 started start VBD cord-005453-4057qib7 13545 7 at at IN cord-005453-4057qib7 13545 8 a a DT cord-005453-4057qib7 13545 9 median median JJ cord-005453-4057qib7 13545 10 time time NN cord-005453-4057qib7 13545 11 of of IN cord-005453-4057qib7 13545 12 day+158 day+158 NNS cord-005453-4057qib7 13545 13 and and CC cord-005453-4057qib7 13545 14 day day NN cord-005453-4057qib7 13545 15 +113 +113 NNP cord-005453-4057qib7 13545 16 in in IN cord-005453-4057qib7 13545 17 the the DT cord-005453-4057qib7 13545 18 group group NN cord-005453-4057qib7 13545 19 without without IN cord-005453-4057qib7 13545 20 symptoms symptom NNS cord-005453-4057qib7 13545 21 . . . cord-005453-4057qib7 13546 1 The the DT cord-005453-4057qib7 13546 2 patient patient NN cord-005453-4057qib7 13546 3 who who WP cord-005453-4057qib7 13546 4 presented present VBD cord-005453-4057qib7 13546 5 the the DT cord-005453-4057qib7 13546 6 autoimmune autoimmune JJ cord-005453-4057qib7 13546 7 thrombopenia thrombopenia NNP cord-005453-4057qib7 13546 8 developed develop VBD cord-005453-4057qib7 13546 9 antibodies antibody NNS cord-005453-4057qib7 13546 10 against against IN cord-005453-4057qib7 13546 11 anti anti JJ cord-005453-4057qib7 13546 12 - - JJ cord-005453-4057qib7 13546 13 gpIIb gpiib JJ cord-005453-4057qib7 13546 14 / / SYM cord-005453-4057qib7 13546 15 IIIa IIIa NNS cord-005453-4057qib7 13546 16 , , , cord-005453-4057qib7 13546 17 this this DT cord-005453-4057qib7 13546 18 was be VBD cord-005453-4057qib7 13546 19 resolved resolve VBN cord-005453-4057qib7 13546 20 after after IN cord-005453-4057qib7 13546 21 130 130 CD cord-005453-4057qib7 13546 22 days day NNS cord-005453-4057qib7 13546 23 , , , cord-005453-4057qib7 13546 24 the the DT cord-005453-4057qib7 13546 25 treatment treatment NN cord-005453-4057qib7 13546 26 consisted consist VBD cord-005453-4057qib7 13546 27 intravenous intravenous JJ cord-005453-4057qib7 13546 28 immunoglobulins immunoglobulin NNS cord-005453-4057qib7 13546 29 ( ( -LRB- cord-005453-4057qib7 13546 30 Ivig Ivig NNP cord-005453-4057qib7 13546 31 ) ) -RRB- cord-005453-4057qib7 13546 32 . . . cord-005453-4057qib7 13547 1 Two two CD cord-005453-4057qib7 13547 2 of of IN cord-005453-4057qib7 13547 3 the the DT cord-005453-4057qib7 13547 4 3 3 CD cord-005453-4057qib7 13547 5 patients patient NNS cord-005453-4057qib7 13547 6 with with IN cord-005453-4057qib7 13547 7 autoimmune autoimmune JJ cord-005453-4057qib7 13547 8 hemolytic hemolytic JJ cord-005453-4057qib7 13547 9 anemia anemia NN cord-005453-4057qib7 13547 10 had have VBD cord-005453-4057qib7 13547 11 IgG IgG NNP cord-005453-4057qib7 13547 12 mediated mediate VBN cord-005453-4057qib7 13547 13 antibodies antibody NNS cord-005453-4057qib7 13547 14 , , , cord-005453-4057qib7 13547 15 and and CC cord-005453-4057qib7 13547 16 1 1 CD cord-005453-4057qib7 13547 17 had have VBD cord-005453-4057qib7 13547 18 complementmediated complementmediate VBN cord-005453-4057qib7 13547 19 DAT DAT NNP cord-005453-4057qib7 13547 20 . . . cord-005453-4057qib7 13548 1 These these DT cord-005453-4057qib7 13548 2 3 3 CD cord-005453-4057qib7 13548 3 patients patient NNS cord-005453-4057qib7 13548 4 were be VBD cord-005453-4057qib7 13548 5 treated treat VBN cord-005453-4057qib7 13548 6 with with IN cord-005453-4057qib7 13548 7 Ivig Ivig NNP cord-005453-4057qib7 13548 8 , , , cord-005453-4057qib7 13548 9 steroids steroid NNS cord-005453-4057qib7 13548 10 , , , cord-005453-4057qib7 13548 11 Rapamune Rapamune NNP cord-005453-4057qib7 13548 12 and and CC cord-005453-4057qib7 13548 13 rituximab rituximab NN cord-005453-4057qib7 13548 14 . . . cord-005453-4057qib7 13549 1 One one CD cord-005453-4057qib7 13549 2 patient patient NN cord-005453-4057qib7 13549 3 has have VBZ cord-005453-4057qib7 13549 4 still still RB cord-005453-4057qib7 13549 5 DAT DAT NNP cord-005453-4057qib7 13549 6 positive positive JJ cord-005453-4057qib7 13549 7 after after IN cord-005453-4057qib7 13549 8 36 36 CD cord-005453-4057qib7 13549 9 months month NNS cord-005453-4057qib7 13549 10 , , , cord-005453-4057qib7 13549 11 but but CC cord-005453-4057qib7 13549 12 clinical clinical JJ cord-005453-4057qib7 13549 13 stable stable NN cord-005453-4057qib7 13549 14 . . . cord-005453-4057qib7 13550 1 The the DT cord-005453-4057qib7 13550 2 other other JJ cord-005453-4057qib7 13550 3 two two CD cord-005453-4057qib7 13550 4 are be VBP cord-005453-4057qib7 13550 5 also also RB cord-005453-4057qib7 13550 6 DAT DAT NNP cord-005453-4057qib7 13550 7 positive positive JJ cord-005453-4057qib7 13550 8 and and CC cord-005453-4057qib7 13550 9 have have VBP cord-005453-4057qib7 13550 10 some some DT cord-005453-4057qib7 13550 11 hemolysis hemolysis NN cord-005453-4057qib7 13550 12 , , , cord-005453-4057qib7 13550 13 but but CC cord-005453-4057qib7 13550 14 the the DT cord-005453-4057qib7 13550 15 follow follow NN cord-005453-4057qib7 13550 16 up up RP cord-005453-4057qib7 13550 17 is be VBZ cord-005453-4057qib7 13550 18 much much RB cord-005453-4057qib7 13550 19 shorter short JJR cord-005453-4057qib7 13550 20 ( ( -LRB- cord-005453-4057qib7 13550 21 2 2 CD cord-005453-4057qib7 13550 22 months month NNS cord-005453-4057qib7 13550 23 ) ) -RRB- cord-005453-4057qib7 13550 24 . . . cord-005453-4057qib7 13551 1 Treosulfan Treosulfan NNP cord-005453-4057qib7 13551 2 - - HYPH cord-005453-4057qib7 13551 3 contained contain VBN cord-005453-4057qib7 13551 4 conditioning conditioning NN cord-005453-4057qib7 13551 5 regimens regimen NNS cord-005453-4057qib7 13551 6 were be VBD cord-005453-4057qib7 13551 7 more more RBR cord-005453-4057qib7 13551 8 frequently frequently RB cord-005453-4057qib7 13551 9 used use VBN cord-005453-4057qib7 13551 10 in in IN cord-005453-4057qib7 13551 11 patients patient NNS cord-005453-4057qib7 13551 12 with with IN cord-005453-4057qib7 13551 13 significant significant JJ cord-005453-4057qib7 13551 14 immune immune JJ cord-005453-4057qib7 13551 15 cytopenia cytopenia NNS cord-005453-4057qib7 13551 16 . . . cord-005453-4057qib7 13552 1 Conclusions conclusion NNS cord-005453-4057qib7 13552 2 : : : cord-005453-4057qib7 13553 1 Immune immune JJ cord-005453-4057qib7 13553 2 cytopenia cytopenia NNP cord-005453-4057qib7 13553 3 is be VBZ cord-005453-4057qib7 13553 4 an an DT cord-005453-4057qib7 13553 5 infrequent infrequent JJ cord-005453-4057qib7 13553 6 complication complication NN cord-005453-4057qib7 13553 7 after after IN cord-005453-4057qib7 13553 8 allogeneic allogeneic NN cord-005453-4057qib7 13553 9 HSCT HSCT NNP cord-005453-4057qib7 13553 10 . . . cord-005453-4057qib7 13554 1 However however RB cord-005453-4057qib7 13554 2 , , , cord-005453-4057qib7 13554 3 its -PRON- PRP$ cord-005453-4057qib7 13554 4 treatment treatment NN cord-005453-4057qib7 13554 5 can can MD cord-005453-4057qib7 13554 6 be be VB cord-005453-4057qib7 13554 7 challenging challenging JJ cord-005453-4057qib7 13554 8 , , , cord-005453-4057qib7 13554 9 and and CC cord-005453-4057qib7 13554 10 the the DT cord-005453-4057qib7 13554 11 hemolysis hemolysis NN cord-005453-4057qib7 13554 12 can can MD cord-005453-4057qib7 13554 13 persist persist VB cord-005453-4057qib7 13554 14 for for IN cord-005453-4057qib7 13554 15 years year NNS cord-005453-4057qib7 13554 16 . . . cord-005453-4057qib7 13555 1 The the DT cord-005453-4057qib7 13555 2 association association NN cord-005453-4057qib7 13555 3 of of IN cord-005453-4057qib7 13555 4 Rapamune Rapamune NNP cord-005453-4057qib7 13555 5 and and CC cord-005453-4057qib7 13555 6 rituximab rituximab NN cord-005453-4057qib7 13555 7 was be VBD cord-005453-4057qib7 13555 8 adequate adequate JJ cord-005453-4057qib7 13555 9 to to TO cord-005453-4057qib7 13555 10 treat treat VB cord-005453-4057qib7 13555 11 this this DT cord-005453-4057qib7 13555 12 problem problem NN cord-005453-4057qib7 13555 13 in in IN cord-005453-4057qib7 13555 14 our -PRON- PRP$ cord-005453-4057qib7 13555 15 patients patient NNS cord-005453-4057qib7 13555 16 . . . cord-005453-4057qib7 13556 1 Background background NN cord-005453-4057qib7 13556 2 : : : cord-005453-4057qib7 13557 1 Approaches approach NNS cord-005453-4057qib7 13557 2 to to IN cord-005453-4057qib7 13557 3 the the DT cord-005453-4057qib7 13557 4 management management NN cord-005453-4057qib7 13557 5 of of IN cord-005453-4057qib7 13557 6 refractory refractory JJ cord-005453-4057qib7 13557 7 and and CC cord-005453-4057qib7 13557 8 relapsed relapse VBD cord-005453-4057qib7 13557 9 classical classical JJ cord-005453-4057qib7 13557 10 Hodgkin´s hodgkin´ NNS cord-005453-4057qib7 13557 11 lymphoma lymphoma NN cord-005453-4057qib7 13557 12 ( ( -LRB- cord-005453-4057qib7 13557 13 r r NN cord-005453-4057qib7 13557 14 - - HYPH cord-005453-4057qib7 13557 15 r r NN cord-005453-4057qib7 13557 16 cHL chl NN cord-005453-4057qib7 13557 17 ) ) -RRB- cord-005453-4057qib7 13557 18 are be VBP cord-005453-4057qib7 13557 19 changing change VBG cord-005453-4057qib7 13557 20 and and CC cord-005453-4057qib7 13557 21 become become VB cord-005453-4057qib7 13557 22 more more RBR cord-005453-4057qib7 13557 23 effective effective JJ cord-005453-4057qib7 13557 24 . . . cord-005453-4057qib7 13558 1 The the DT cord-005453-4057qib7 13558 2 role role NN cord-005453-4057qib7 13558 3 of of IN cord-005453-4057qib7 13558 4 anti anti JJ cord-005453-4057qib7 13558 5 - - JJ cord-005453-4057qib7 13558 6 CD30 CD30 NNP cord-005453-4057qib7 13558 7 targeted target VBD cord-005453-4057qib7 13558 8 immunochemotherapy immunochemotherapy NN cord-005453-4057qib7 13558 9 with with IN cord-005453-4057qib7 13558 10 Brentuximab Brentuximab NNP cord-005453-4057qib7 13558 11 vedotin vedotin NNP cord-005453-4057qib7 13558 12 ( ( -LRB- cord-005453-4057qib7 13558 13 BV BV NNP cord-005453-4057qib7 13558 14 ) ) -RRB- cord-005453-4057qib7 13558 15 has have VBZ cord-005453-4057qib7 13558 16 been be VBN cord-005453-4057qib7 13558 17 extensively extensively RB cord-005453-4057qib7 13558 18 investigated investigate VBN cord-005453-4057qib7 13558 19 in in IN cord-005453-4057qib7 13558 20 adults adult NNS cord-005453-4057qib7 13558 21 with with IN cord-005453-4057qib7 13558 22 r r NN cord-005453-4057qib7 13558 23 - - HYPH cord-005453-4057qib7 13558 24 r r JJ cord-005453-4057qib7 13558 25 cHL chl NN cord-005453-4057qib7 13558 26 and and CC cord-005453-4057qib7 13558 27 is be VBZ cord-005453-4057qib7 13558 28 only only RB cord-005453-4057qib7 13558 29 to to TO cord-005453-4057qib7 13558 30 be be VB cord-005453-4057qib7 13558 31 elucidated elucidate VBN cord-005453-4057qib7 13558 32 in in IN cord-005453-4057qib7 13558 33 children child NNS cord-005453-4057qib7 13558 34 . . . cord-005453-4057qib7 13559 1 The the DT cord-005453-4057qib7 13559 2 study study NN cord-005453-4057qib7 13559 3 included include VBD cord-005453-4057qib7 13559 4 14 14 CD cord-005453-4057qib7 13559 5 children child NNS cord-005453-4057qib7 13559 6 and and CC cord-005453-4057qib7 13559 7 adolescents adolescent NNS cord-005453-4057qib7 13559 8 with with IN cord-005453-4057qib7 13559 9 r r NN cord-005453-4057qib7 13559 10 - - HYPH cord-005453-4057qib7 13559 11 r r NN cord-005453-4057qib7 13559 12 cHL chl NN cord-005453-4057qib7 13559 13 that that WDT cord-005453-4057qib7 13559 14 were be VBD cord-005453-4057qib7 13559 15 sucessfully sucessfully RB cord-005453-4057qib7 13559 16 treated treat VBN cord-005453-4057qib7 13559 17 with with IN cord-005453-4057qib7 13559 18 BV BV NNP cord-005453-4057qib7 13559 19 - - HYPH cord-005453-4057qib7 13559 20 based base VBN cord-005453-4057qib7 13559 21 therapy therapy NN cord-005453-4057qib7 13559 22 prior prior RB cord-005453-4057qib7 13559 23 to to IN cord-005453-4057qib7 13559 24 hematopoetic hematopoetic JJ cord-005453-4057qib7 13559 25 stem stem NN cord-005453-4057qib7 13559 26 cell cell NN cord-005453-4057qib7 13559 27 transplantation transplantation NN cord-005453-4057qib7 13559 28 ( ( -LRB- cord-005453-4057qib7 13559 29 HSCT HSCT NNP cord-005453-4057qib7 13559 30 ) ) -RRB- cord-005453-4057qib7 13559 31 . . . cord-005453-4057qib7 13560 1 Median median JJ cord-005453-4057qib7 13560 2 age age NN cord-005453-4057qib7 13560 3 of of IN cord-005453-4057qib7 13560 4 patients patient NNS cord-005453-4057qib7 13560 5 was be VBD cord-005453-4057qib7 13560 6 16 16 CD cord-005453-4057qib7 13560 7 years year NNS cord-005453-4057qib7 13560 8 ( ( -LRB- cord-005453-4057qib7 13560 9 9 9 CD cord-005453-4057qib7 13560 10 - - SYM cord-005453-4057qib7 13560 11 19 19 CD cord-005453-4057qib7 13560 12 ) ) -RRB- cord-005453-4057qib7 13560 13 , , . cord-005453-4057qib7 13561 1 main main JJ cord-005453-4057qib7 13561 2 histological histological JJ cord-005453-4057qib7 13561 3 variant variant NN cord-005453-4057qib7 13561 4 -nodular -nodular CD cord-005453-4057qib7 13561 5 sclerosis sclerosis NN cord-005453-4057qib7 13561 6 ( ( -LRB- cord-005453-4057qib7 13561 7 93 93 CD cord-005453-4057qib7 13561 8 % % NN cord-005453-4057qib7 13561 9 , , , cord-005453-4057qib7 13561 10 n=13 n=13 NNP cord-005453-4057qib7 13561 11 ) ) -RRB- cord-005453-4057qib7 13561 12 , , , cord-005453-4057qib7 13561 13 advanced advanced JJ cord-005453-4057qib7 13561 14 stage stage NN cord-005453-4057qib7 13561 15 at at IN cord-005453-4057qib7 13561 16 diagnosis diagnosis NN cord-005453-4057qib7 13561 17 -86 -86 NNP cord-005453-4057qib7 13561 18 % % NN cord-005453-4057qib7 13561 19 ( ( -LRB- cord-005453-4057qib7 13561 20 n=12 n=12 NNP cord-005453-4057qib7 13561 21 ) ) -RRB- cord-005453-4057qib7 13561 22 . . . cord-005453-4057qib7 13562 1 Most Most JJS cord-005453-4057qib7 13562 2 were be VBD cord-005453-4057qib7 13562 3 heavily heavily RB cord-005453-4057qib7 13562 4 pre pre VBN cord-005453-4057qib7 13562 5 - - VBN cord-005453-4057qib7 13562 6 treated treated JJ cord-005453-4057qib7 13562 7 ( ( -LRB- cord-005453-4057qib7 13562 8 median median JJ cord-005453-4057qib7 13562 9 number number NN cord-005453-4057qib7 13562 10 of of IN cord-005453-4057qib7 13562 11 previous previous JJ cord-005453-4057qib7 13562 12 therapies therapy NNS cord-005453-4057qib7 13562 13 -4 -4 NFP cord-005453-4057qib7 13562 14 ) ) -RRB- cord-005453-4057qib7 13562 15 and and CC cord-005453-4057qib7 13562 16 progression progression NN cord-005453-4057qib7 13562 17 after after IN cord-005453-4057qib7 13562 18 autologous autologous JJ cord-005453-4057qib7 13562 19 HSCT HSCT NNP cord-005453-4057qib7 13562 20 was be VBD cord-005453-4057qib7 13562 21 documented document VBN cord-005453-4057qib7 13562 22 in in IN cord-005453-4057qib7 13562 23 4 4 CD cord-005453-4057qib7 13562 24 ( ( -LRB- cord-005453-4057qib7 13562 25 29 29 CD cord-005453-4057qib7 13562 26 % % NN cord-005453-4057qib7 13562 27 ) ) -RRB- cord-005453-4057qib7 13562 28 . . . cord-005453-4057qib7 13563 1 Refractory refractory JJ cord-005453-4057qib7 13563 2 disease disease NN cord-005453-4057qib7 13563 3 was be VBD cord-005453-4057qib7 13563 4 diagnosed diagnose VBN cord-005453-4057qib7 13563 5 in in IN cord-005453-4057qib7 13563 6 8 8 CD cord-005453-4057qib7 13563 7 ( ( -LRB- cord-005453-4057qib7 13563 8 57 57 CD cord-005453-4057qib7 13563 9 % % NN cord-005453-4057qib7 13563 10 ) ) -RRB- cord-005453-4057qib7 13563 11 and and CC cord-005453-4057qib7 13563 12 relapsed relapse VBD cord-005453-4057qib7 13563 13 in in IN cord-005453-4057qib7 13563 14 6 6 CD cord-005453-4057qib7 13563 15 ( ( -LRB- cord-005453-4057qib7 13563 16 43 43 CD cord-005453-4057qib7 13563 17 % % NN cord-005453-4057qib7 13563 18 ) ) -RRB- cord-005453-4057qib7 13563 19 . . . cord-005453-4057qib7 13564 1 Among among IN cord-005453-4057qib7 13564 2 relapsed relapse VBN cord-005453-4057qib7 13564 3 patients patient NNS cord-005453-4057qib7 13564 4 4 4 CD cord-005453-4057qib7 13564 5 ( ( -LRB- cord-005453-4057qib7 13564 6 67 67 CD cord-005453-4057qib7 13564 7 % % NN cord-005453-4057qib7 13564 8 ) ) -RRB- cord-005453-4057qib7 13564 9 were be VBD cord-005453-4057qib7 13564 10 with with IN cord-005453-4057qib7 13564 11 multiple multiple JJ cord-005453-4057qib7 13564 12 episodes episode NNS cord-005453-4057qib7 13564 13 , , , cord-005453-4057qib7 13564 14 1 1 CD cord-005453-4057qib7 13564 15 ( ( -LRB- cord-005453-4057qib7 13564 16 16.5 16.5 CD cord-005453-4057qib7 13564 17 % % NN cord-005453-4057qib7 13564 18 ) ) -RRB- cord-005453-4057qib7 13565 1 -early -early . cord-005453-4057qib7 13566 1 and and CC cord-005453-4057qib7 13566 2 1 1 CD cord-005453-4057qib7 13566 3 ( ( -LRB- cord-005453-4057qib7 13566 4 16.5 16.5 CD cord-005453-4057qib7 13566 5 % % NN cord-005453-4057qib7 13566 6 ) ) -RRB- cord-005453-4057qib7 13566 7 -late -late NN cord-005453-4057qib7 13566 8 relapse relapse NN cord-005453-4057qib7 13566 9 . . . cord-005453-4057qib7 13567 1 Treatment treatment NN cord-005453-4057qib7 13567 2 regimens regimen NNS cord-005453-4057qib7 13567 3 consisted consist VBN cord-005453-4057qib7 13567 4 of of IN cord-005453-4057qib7 13567 5 BV BV NNP cord-005453-4057qib7 13567 6 in in IN cord-005453-4057qib7 13567 7 monotherapy monotherapy NN cord-005453-4057qib7 13567 8 1.8 1.8 CD cord-005453-4057qib7 13567 9 mg mg NNP cord-005453-4057qib7 13567 10 / / SYM cord-005453-4057qib7 13567 11 kg kg NNP cord-005453-4057qib7 13567 12 triweekly triweekly NNP cord-005453-4057qib7 13567 13 ( ( -LRB- cord-005453-4057qib7 13567 14 n=7 n=7 NNP cord-005453-4057qib7 13567 15 ) ) -RRB- cord-005453-4057qib7 13567 16 or or CC cord-005453-4057qib7 13567 17 combination combination NN cord-005453-4057qib7 13567 18 of of IN cord-005453-4057qib7 13567 19 BV BV NNP cord-005453-4057qib7 13567 20 1.8 1.8 CD cord-005453-4057qib7 13567 21 mg mg NNP cord-005453-4057qib7 13567 22 / / SYM cord-005453-4057qib7 13567 23 kg kg NNP cord-005453-4057qib7 13567 24 on on IN cord-005453-4057qib7 13567 25 Day day NN cord-005453-4057qib7 13567 26 1 1 CD cord-005453-4057qib7 13567 27 with with IN cord-005453-4057qib7 13567 28 Bendamustine Bendamustine NNP cord-005453-4057qib7 13567 29 90 90 CD cord-005453-4057qib7 13567 30 - - SYM cord-005453-4057qib7 13567 31 120 120 CD cord-005453-4057qib7 13567 32 mg/ mg/ NN cord-005453-4057qib7 13567 33 m2 m2 NNP cord-005453-4057qib7 13567 34 on on IN cord-005453-4057qib7 13567 35 Days day NNS cord-005453-4057qib7 13567 36 1 1 CD cord-005453-4057qib7 13567 37 and and CC cord-005453-4057qib7 13567 38 2 2 CD cord-005453-4057qib7 13567 39 of of IN cord-005453-4057qib7 13567 40 3-week 3-week CD cord-005453-4057qib7 13567 41 cycles cycle NNS cord-005453-4057qib7 13567 42 ( ( -LRB- cord-005453-4057qib7 13567 43 n=5 n=5 NNP cord-005453-4057qib7 13567 44 ) ) -RRB- cord-005453-4057qib7 13567 45 or or CC cord-005453-4057qib7 13567 46 combination combination NN cord-005453-4057qib7 13567 47 of of IN cord-005453-4057qib7 13567 48 BV BV NNP cord-005453-4057qib7 13567 49 1.8 1.8 CD cord-005453-4057qib7 13567 50 mg mg NNP cord-005453-4057qib7 13567 51 / / SYM cord-005453-4057qib7 13567 52 kg kg NNP cord-005453-4057qib7 13567 53 on on IN cord-005453-4057qib7 13567 54 Day Day NNP cord-005453-4057qib7 13567 55 1 1 CD cord-005453-4057qib7 13567 56 with with IN cord-005453-4057qib7 13567 57 DHAP DHAP NNP cord-005453-4057qib7 13567 58 ( ( -LRB- cord-005453-4057qib7 13567 59 n=2 n=2 NNS cord-005453-4057qib7 13567 60 ) ) -RRB- cord-005453-4057qib7 13567 61 . . . cord-005453-4057qib7 13568 1 Median median JJ cord-005453-4057qib7 13568 2 number number NN cord-005453-4057qib7 13568 3 of of IN cord-005453-4057qib7 13568 4 BV BV NNP cord-005453-4057qib7 13568 5 infusions infusion NNS cord-005453-4057qib7 13568 6 was be VBD cord-005453-4057qib7 13568 7 3.5 3.5 CD cord-005453-4057qib7 13568 8 ( ( -LRB- cord-005453-4057qib7 13568 9 2 2 CD cord-005453-4057qib7 13568 10 - - SYM cord-005453-4057qib7 13568 11 7 7 CD cord-005453-4057qib7 13568 12 ) ) -RRB- cord-005453-4057qib7 13568 13 . . . cord-005453-4057qib7 13569 1 All all DT cord-005453-4057qib7 13569 2 selected select VBN cord-005453-4057qib7 13569 3 patients patient NNS cord-005453-4057qib7 13569 4 achieved achieve VBD cord-005453-4057qib7 13569 5 complete complete JJ cord-005453-4057qib7 13569 6 ( ( -LRB- cord-005453-4057qib7 13569 7 n=5 n=5 JJ cord-005453-4057qib7 13569 8 , , , cord-005453-4057qib7 13569 9 36 36 CD cord-005453-4057qib7 13569 10 % % NN cord-005453-4057qib7 13569 11 ) ) -RRB- cord-005453-4057qib7 13569 12 or or CC cord-005453-4057qib7 13569 13 partial partial JJ cord-005453-4057qib7 13569 14 remission remission NN cord-005453-4057qib7 13569 15 ( ( -LRB- cord-005453-4057qib7 13569 16 n=9 n=9 NN cord-005453-4057qib7 13569 17 , , , cord-005453-4057qib7 13569 18 64 64 CD cord-005453-4057qib7 13569 19 % % NN cord-005453-4057qib7 13569 20 ) ) -RRB- cord-005453-4057qib7 13569 21 prior prior RB cord-005453-4057qib7 13569 22 to to IN cord-005453-4057qib7 13569 23 HSCT HSCT NNP cord-005453-4057qib7 13569 24 . . . cord-005453-4057qib7 13570 1 Consolidation consolidation NN cord-005453-4057qib7 13570 2 with with IN cord-005453-4057qib7 13570 3 autologous autologous JJ cord-005453-4057qib7 13570 4 HSCT HSCT NNP cord-005453-4057qib7 13570 5 was be VBD cord-005453-4057qib7 13570 6 performed perform VBN cord-005453-4057qib7 13570 7 in in IN cord-005453-4057qib7 13570 8 9 9 CD cord-005453-4057qib7 13570 9 ( ( -LRB- cord-005453-4057qib7 13570 10 64 64 CD cord-005453-4057qib7 13570 11 % % NN cord-005453-4057qib7 13570 12 ) ) -RRB- cord-005453-4057qib7 13570 13 and and CC cord-005453-4057qib7 13570 14 with with IN cord-005453-4057qib7 13570 15 allogeneic allogeneic JJ cord-005453-4057qib7 13570 16 HSCT HSCT NNP cord-005453-4057qib7 13570 17 -in -in . cord-005453-4057qib7 13571 1 5 5 LS cord-005453-4057qib7 13571 2 ( ( -LRB- cord-005453-4057qib7 13571 3 36 36 CD cord-005453-4057qib7 13571 4 % % NN cord-005453-4057qib7 13571 5 ) ) -RRB- cord-005453-4057qib7 13571 6 . . . cord-005453-4057qib7 13572 1 Primary primary JJ cord-005453-4057qib7 13572 2 end end NN cord-005453-4057qib7 13572 3 points point NNS cord-005453-4057qib7 13572 4 were be VBD cord-005453-4057qib7 13572 5 overall overall JJ cord-005453-4057qib7 13572 6 ( ( -LRB- cord-005453-4057qib7 13572 7 OS OS NNP cord-005453-4057qib7 13572 8 ) ) -RRB- cord-005453-4057qib7 13572 9 and and CC cord-005453-4057qib7 13572 10 progression progression NN cord-005453-4057qib7 13572 11 free free JJ cord-005453-4057qib7 13572 12 survival survival NN cord-005453-4057qib7 13572 13 ( ( -LRB- cord-005453-4057qib7 13572 14 PFS PFS NNP cord-005453-4057qib7 13572 15 ) ) -RRB- cord-005453-4057qib7 13572 16 . . . cord-005453-4057qib7 13573 1 Response response NN cord-005453-4057qib7 13573 2 to to IN cord-005453-4057qib7 13573 3 BV BV NNP cord-005453-4057qib7 13573 4 was be VBD cord-005453-4057qib7 13573 5 not not RB cord-005453-4057qib7 13573 6 assessed assess VBN cord-005453-4057qib7 13573 7 in in IN cord-005453-4057qib7 13573 8 the the DT cord-005453-4057qib7 13573 9 study study NN cord-005453-4057qib7 13573 10 as as IN cord-005453-4057qib7 13573 11 only only JJ cord-005453-4057qib7 13573 12 responders responder NNS cord-005453-4057qib7 13573 13 to to IN cord-005453-4057qib7 13573 14 the the DT cord-005453-4057qib7 13573 15 BV BV NNP cord-005453-4057qib7 13573 16 - - HYPH cord-005453-4057qib7 13573 17 based base VBN cord-005453-4057qib7 13573 18 treatment treatment NN cord-005453-4057qib7 13573 19 were be VBD cord-005453-4057qib7 13573 20 included include VBN cord-005453-4057qib7 13573 21 . . . cord-005453-4057qib7 13574 1 Results result NNS cord-005453-4057qib7 13574 2 : : : cord-005453-4057qib7 13575 1 With with IN cord-005453-4057qib7 13575 2 median median JJ cord-005453-4057qib7 13575 3 follow follow NN cord-005453-4057qib7 13575 4 - - HYPH cord-005453-4057qib7 13575 5 up up NN cord-005453-4057qib7 13575 6 of of IN cord-005453-4057qib7 13575 7 497 497 CD cord-005453-4057qib7 13575 8 days day NNS cord-005453-4057qib7 13575 9 ( ( -LRB- cord-005453-4057qib7 13575 10 105 105 CD cord-005453-4057qib7 13575 11 - - SYM cord-005453-4057qib7 13575 12 1368 1368 CD cord-005453-4057qib7 13575 13 ) ) -RRB- cord-005453-4057qib7 13575 14 OS OS NNP cord-005453-4057qib7 13575 15 and and CC cord-005453-4057qib7 13575 16 PFS PFS NNP cord-005453-4057qib7 13575 17 for for IN cord-005453-4057qib7 13575 18 all all DT cord-005453-4057qib7 13575 19 patients patient NNS cord-005453-4057qib7 13575 20 are be VBP cord-005453-4057qib7 13575 21 68 68 CD cord-005453-4057qib7 13575 22 % % NN cord-005453-4057qib7 13575 23 and and CC cord-005453-4057qib7 13575 24 66 66 CD cord-005453-4057qib7 13575 25 % % NN cord-005453-4057qib7 13575 26 , , , cord-005453-4057qib7 13575 27 respectively respectively RB cord-005453-4057qib7 13575 28 . . . cord-005453-4057qib7 13576 1 PFS PFS NNP cord-005453-4057qib7 13576 2 after after IN cord-005453-4057qib7 13576 3 autologous autologous JJ cord-005453-4057qib7 13576 4 HSCT HSCT NNP cord-005453-4057qib7 13576 5 and and CC cord-005453-4057qib7 13576 6 allogeneic allogeneic IN cord-005453-4057qib7 13576 7 HSCT HSCT NNP cord-005453-4057qib7 13576 8 are be VBP cord-005453-4057qib7 13576 9 70 70 CD cord-005453-4057qib7 13576 10 % % NN cord-005453-4057qib7 13576 11 and and CC cord-005453-4057qib7 13576 12 60 60 CD cord-005453-4057qib7 13576 13 % % NN cord-005453-4057qib7 13576 14 , , , cord-005453-4057qib7 13576 15 respectively respectively RB cord-005453-4057qib7 13576 16 ( ( -LRB- cord-005453-4057qib7 13576 17 p=0.7 p=0.7 NNP cord-005453-4057qib7 13576 18 ) ) -RRB- cord-005453-4057qib7 13577 1 At at IN cord-005453-4057qib7 13577 2 present present JJ cord-005453-4057qib7 13577 3 moment moment NN cord-005453-4057qib7 13577 4 10 10 CD cord-005453-4057qib7 13577 5 ( ( -LRB- cord-005453-4057qib7 13577 6 71 71 CD cord-005453-4057qib7 13577 7 % % NN cord-005453-4057qib7 13577 8 ) ) -RRB- cord-005453-4057qib7 13577 9 patients patient NNS cord-005453-4057qib7 13577 10 are be VBP cord-005453-4057qib7 13577 11 alive alive JJ cord-005453-4057qib7 13577 12 and and CC cord-005453-4057qib7 13577 13 are be VBP cord-005453-4057qib7 13577 14 in in IN cord-005453-4057qib7 13577 15 remission remission NN cord-005453-4057qib7 13577 16 . . . cord-005453-4057qib7 13578 1 Three three CD cord-005453-4057qib7 13578 2 patients patient NNS cord-005453-4057qib7 13578 3 died die VBD cord-005453-4057qib7 13578 4 ( ( -LRB- cord-005453-4057qib7 13578 5 21 21 CD cord-005453-4057qib7 13578 6 % % NN cord-005453-4057qib7 13578 7 ) ) -RRB- cord-005453-4057qib7 13578 8 : : : cord-005453-4057qib7 13578 9 disease disease NN cord-005453-4057qib7 13578 10 progression progression NN cord-005453-4057qib7 13578 11 ( ( -LRB- cord-005453-4057qib7 13578 12 n=1 n=1 NNP cord-005453-4057qib7 13578 13 ) ) -RRB- cord-005453-4057qib7 13578 14 , , , cord-005453-4057qib7 13578 15 postransplant postransplant JJ cord-005453-4057qib7 13578 16 idiopathic idiopathic JJ cord-005453-4057qib7 13578 17 pneumonia pneumonia NN cord-005453-4057qib7 13578 18 syndrome syndrome NN cord-005453-4057qib7 13578 19 ( ( -LRB- cord-005453-4057qib7 13578 20 n=1 n=1 NNP cord-005453-4057qib7 13578 21 ) ) -RRB- cord-005453-4057qib7 13578 22 and and CC cord-005453-4057qib7 13578 23 posttransplant posttransplant NNP cord-005453-4057qib7 13578 24 pneumonia pneumonia NN cord-005453-4057qib7 13578 25 ( ( -LRB- cord-005453-4057qib7 13578 26 n=1 n=1 FW cord-005453-4057qib7 13578 27 ) ) -RRB- cord-005453-4057qib7 13578 28 . . . cord-005453-4057qib7 13579 1 BV BV NNP cord-005453-4057qib7 13579 2 was be VBD cord-005453-4057qib7 13579 3 generally generally RB cord-005453-4057qib7 13579 4 well well RB cord-005453-4057qib7 13579 5 tolerated tolerate VBN cord-005453-4057qib7 13579 6 with with IN cord-005453-4057qib7 13579 7 only only JJ cord-005453-4057qib7 13579 8 mild mild JJ cord-005453-4057qib7 13579 9 polyneuropathy polyneuropathy NNS cord-005453-4057qib7 13579 10 in in IN cord-005453-4057qib7 13579 11 3 3 CD cord-005453-4057qib7 13579 12 patients patient NNS cord-005453-4057qib7 13579 13 ( ( -LRB- cord-005453-4057qib7 13579 14 21 21 CD cord-005453-4057qib7 13579 15 % % NN cord-005453-4057qib7 13579 16 ) ) -RRB- cord-005453-4057qib7 13579 17 as as IN cord-005453-4057qib7 13579 18 the the DT cord-005453-4057qib7 13579 19 main main JJ cord-005453-4057qib7 13579 20 reversable reversable NN cord-005453-4057qib7 13579 21 documented document VBD cord-005453-4057qib7 13579 22 adverse adverse JJ cord-005453-4057qib7 13579 23 event event NN cord-005453-4057qib7 13579 24 . . . cord-005453-4057qib7 13580 1 Conclusions conclusion NNS cord-005453-4057qib7 13580 2 : : : cord-005453-4057qib7 13581 1 In in IN cord-005453-4057qib7 13581 2 prognostically prognostically RB cord-005453-4057qib7 13581 3 unfavourable unfavourable JJ cord-005453-4057qib7 13581 4 heavily heavily RB cord-005453-4057qib7 13581 5 pretreated pretreate VBN cord-005453-4057qib7 13581 6 children child NNS cord-005453-4057qib7 13581 7 and and CC cord-005453-4057qib7 13581 8 adolescents adolescent NNS cord-005453-4057qib7 13581 9 with with IN cord-005453-4057qib7 13581 10 r r NN cord-005453-4057qib7 13581 11 - - HYPH cord-005453-4057qib7 13581 12 r r JJ cord-005453-4057qib7 13581 13 cHL chl NN cord-005453-4057qib7 13581 14 achievement achievement NN cord-005453-4057qib7 13581 15 of of IN cord-005453-4057qib7 13581 16 response response NN cord-005453-4057qib7 13581 17 to to IN cord-005453-4057qib7 13581 18 BV BV NNP cord-005453-4057qib7 13581 19 - - HYPH cord-005453-4057qib7 13581 20 based base VBN cord-005453-4057qib7 13581 21 therapy therapy NN cord-005453-4057qib7 13581 22 prior prior RB cord-005453-4057qib7 13581 23 to to IN cord-005453-4057qib7 13581 24 HSCT HSCT NNP cord-005453-4057qib7 13581 25 is be VBZ cord-005453-4057qib7 13581 26 assosiated assosiate VBN cord-005453-4057qib7 13581 27 with with IN cord-005453-4057qib7 13581 28 promising promising JJ cord-005453-4057qib7 13581 29 rates rate NNS cord-005453-4057qib7 13581 30 of of IN cord-005453-4057qib7 13581 31 OS OS NNP cord-005453-4057qib7 13581 32 and and CC cord-005453-4057qib7 13581 33 PFS PFS NNP cord-005453-4057qib7 13581 34 . . . cord-005453-4057qib7 13582 1 Disclosure disclosure NN cord-005453-4057qib7 13582 2 provides provide VBZ cord-005453-4057qib7 13582 3 a a DT cord-005453-4057qib7 13582 4 treatment treatment NN cord-005453-4057qib7 13582 5 by by IN cord-005453-4057qib7 13582 6 restoring restore VBG cord-005453-4057qib7 13582 7 thymidine thymidine FW cord-005453-4057qib7 13582 8 phosphorylase phosphorylase NN cord-005453-4057qib7 13582 9 function function NN cord-005453-4057qib7 13582 10 and and CC cord-005453-4057qib7 13582 11 improving improve VBG cord-005453-4057qib7 13582 12 disease disease NN cord-005453-4057qib7 13582 13 manifestations manifestation NNS cord-005453-4057qib7 13582 14 . . . cord-005453-4057qib7 13583 1 Here here RB cord-005453-4057qib7 13583 2 we -PRON- PRP cord-005453-4057qib7 13583 3 report report VBP cord-005453-4057qib7 13583 4 the the DT cord-005453-4057qib7 13583 5 outcomes outcome NNS cord-005453-4057qib7 13583 6 of of IN cord-005453-4057qib7 13583 7 4 4 CD cord-005453-4057qib7 13583 8 affected affected JJ cord-005453-4057qib7 13583 9 siblings sibling NNS cord-005453-4057qib7 13583 10 who who WP cord-005453-4057qib7 13583 11 underwent undergo VBD cord-005453-4057qib7 13583 12 transplantation transplantation NN cord-005453-4057qib7 13583 13 using use VBG cord-005453-4057qib7 13583 14 an an DT cord-005453-4057qib7 13583 15 unaffected unaffected JJ cord-005453-4057qib7 13583 16 sibling sibling NN cord-005453-4057qib7 13583 17 donor donor NN cord-005453-4057qib7 13583 18 to to TO cord-005453-4057qib7 13583 19 highlight highlight VB cord-005453-4057qib7 13583 20 important important JJ cord-005453-4057qib7 13583 21 experiences experience NNS cord-005453-4057qib7 13583 22 in in IN cord-005453-4057qib7 13583 23 the the DT cord-005453-4057qib7 13583 24 transplant transplant NN cord-005453-4057qib7 13583 25 of of IN cord-005453-4057qib7 13583 26 such such PDT cord-005453-4057qib7 13583 27 a a DT cord-005453-4057qib7 13583 28 rare rare JJ cord-005453-4057qib7 13583 29 condition condition NN cord-005453-4057qib7 13583 30 . . . cord-005453-4057qib7 13584 1 Methods method NNS cord-005453-4057qib7 13584 2 : : : cord-005453-4057qib7 13585 1 Four four CD cord-005453-4057qib7 13585 2 siblings sibling NNS cord-005453-4057qib7 13585 3 of of IN cord-005453-4057qib7 13585 4 consanguineous consanguineous JJ cord-005453-4057qib7 13585 5 Pakistani pakistani JJ cord-005453-4057qib7 13585 6 descent descent NN cord-005453-4057qib7 13585 7 aged age VBN cord-005453-4057qib7 13585 8 16 16 CD cord-005453-4057qib7 13585 9 , , , cord-005453-4057qib7 13585 10 15 15 CD cord-005453-4057qib7 13585 11 , , , cord-005453-4057qib7 13585 12 13 13 CD cord-005453-4057qib7 13585 13 and and CC cord-005453-4057qib7 13585 14 5 5 CD cord-005453-4057qib7 13585 15 years year NNS cord-005453-4057qib7 13585 16 underwent undergo VBD cord-005453-4057qib7 13585 17 myeloablative myeloablative JJ cord-005453-4057qib7 13585 18 HSCT HSCT NNP cord-005453-4057qib7 13585 19 using use VBG cord-005453-4057qib7 13585 20 fully fully RB cord-005453-4057qib7 13585 21 HLA HLA NNP cord-005453-4057qib7 13585 22 - - HYPH cord-005453-4057qib7 13585 23 matched match VBN cord-005453-4057qib7 13585 24 ( ( -LRB- cord-005453-4057qib7 13585 25 10/10 10/10 CD cord-005453-4057qib7 13585 26 ) ) -RRB- cord-005453-4057qib7 13585 27 peripheral peripheral JJ cord-005453-4057qib7 13585 28 blood blood NN cord-005453-4057qib7 13585 29 stem stem NN cord-005453-4057qib7 13585 30 cells cell NNS cord-005453-4057qib7 13585 31 harvested harvest VBN cord-005453-4057qib7 13585 32 in in IN cord-005453-4057qib7 13585 33 a a DT cord-005453-4057qib7 13585 34 single single JJ cord-005453-4057qib7 13585 35 apheresis apheresis NN cord-005453-4057qib7 13585 36 from from IN cord-005453-4057qib7 13585 37 an an DT cord-005453-4057qib7 13585 38 unaffected unaffected JJ cord-005453-4057qib7 13585 39 9 9 CD cord-005453-4057qib7 13585 40 year year NN cord-005453-4057qib7 13585 41 old old JJ cord-005453-4057qib7 13585 42 sibling sibling NN cord-005453-4057qib7 13585 43 . . . cord-005453-4057qib7 13586 1 The the DT cord-005453-4057qib7 13586 2 oldest old JJS cord-005453-4057qib7 13586 3 sibling sibling NN cord-005453-4057qib7 13586 4 , , , cord-005453-4057qib7 13586 5 a a DT cord-005453-4057qib7 13586 6 16 16 CD cord-005453-4057qib7 13586 7 year year NN cord-005453-4057qib7 13586 8 old old JJ cord-005453-4057qib7 13586 9 male male NN cord-005453-4057qib7 13586 10 , , , cord-005453-4057qib7 13586 11 first first RB cord-005453-4057qib7 13586 12 presented present VBN cord-005453-4057qib7 13586 13 in in IN cord-005453-4057qib7 13586 14 2016 2016 CD cord-005453-4057qib7 13586 15 having have VBG cord-005453-4057qib7 13586 16 emigrated emigrate VBN cord-005453-4057qib7 13586 17 from from IN cord-005453-4057qib7 13586 18 Pakistan Pakistan NNP cord-005453-4057qib7 13586 19 with with IN cord-005453-4057qib7 13586 20 a a DT cord-005453-4057qib7 13586 21 history history NN cord-005453-4057qib7 13586 22 of of IN cord-005453-4057qib7 13586 23 growth growth NN cord-005453-4057qib7 13586 24 failure failure NN cord-005453-4057qib7 13586 25 and and CC cord-005453-4057qib7 13586 26 abnormal abnormal JJ cord-005453-4057qib7 13586 27 movements movement NNS cord-005453-4057qib7 13586 28 . . . cord-005453-4057qib7 13587 1 Biochemical biochemical JJ cord-005453-4057qib7 13587 2 , , , cord-005453-4057qib7 13587 3 nerve nerve NN cord-005453-4057qib7 13587 4 conduction conduction NN cord-005453-4057qib7 13587 5 and and CC cord-005453-4057qib7 13587 6 imaging imaging NN cord-005453-4057qib7 13587 7 studies study NNS cord-005453-4057qib7 13587 8 confirmed confirm VBD cord-005453-4057qib7 13587 9 a a DT cord-005453-4057qib7 13587 10 diagnosis diagnosis NN cord-005453-4057qib7 13587 11 of of IN cord-005453-4057qib7 13587 12 MNGIE MNGIE NNP cord-005453-4057qib7 13587 13 . . . cord-005453-4057qib7 13588 1 Testing test VBG cord-005453-4057qib7 13588 2 on on IN cord-005453-4057qib7 13588 3 three three CD cord-005453-4057qib7 13588 4 other other JJ cord-005453-4057qib7 13588 5 siblings sibling NNS cord-005453-4057qib7 13588 6 identified identify VBD cord-005453-4057qib7 13588 7 similar similar JJ cord-005453-4057qib7 13588 8 biochemical biochemical JJ cord-005453-4057qib7 13588 9 abnormalities abnormality NNS cord-005453-4057qib7 13588 10 , , , cord-005453-4057qib7 13588 11 though though IN cord-005453-4057qib7 13588 12 the the DT cord-005453-4057qib7 13588 13 2 2 CD cord-005453-4057qib7 13588 14 youngest young JJS cord-005453-4057qib7 13588 15 children child NNS cord-005453-4057qib7 13588 16 had have VBD cord-005453-4057qib7 13588 17 minimal minimal JJ cord-005453-4057qib7 13588 18 clinical clinical JJ cord-005453-4057qib7 13588 19 manifestations manifestation NNS cord-005453-4057qib7 13588 20 of of IN cord-005453-4057qib7 13588 21 the the DT cord-005453-4057qib7 13588 22 disease disease NN cord-005453-4057qib7 13588 23 . . . cord-005453-4057qib7 13589 1 Based base VBN cord-005453-4057qib7 13589 2 on on IN cord-005453-4057qib7 13589 3 the the DT cord-005453-4057qib7 13589 4 progressive progressive JJ cord-005453-4057qib7 13589 5 nature nature NN cord-005453-4057qib7 13589 6 of of IN cord-005453-4057qib7 13589 7 the the DT cord-005453-4057qib7 13589 8 disease disease NN cord-005453-4057qib7 13589 9 and and CC cord-005453-4057qib7 13589 10 the the DT cord-005453-4057qib7 13589 11 availability availability NN cord-005453-4057qib7 13589 12 of of IN cord-005453-4057qib7 13589 13 a a DT cord-005453-4057qib7 13589 14 fully fully RB cord-005453-4057qib7 13589 15 matched match VBN cord-005453-4057qib7 13589 16 donor donor NN cord-005453-4057qib7 13589 17 , , , cord-005453-4057qib7 13589 18 a a DT cord-005453-4057qib7 13589 19 decision decision NN cord-005453-4057qib7 13589 20 was be VBD cord-005453-4057qib7 13589 21 made make VBN cord-005453-4057qib7 13589 22 to to TO cord-005453-4057qib7 13589 23 pursue pursue VB cord-005453-4057qib7 13589 24 transplant transplant NN cord-005453-4057qib7 13589 25 for for IN cord-005453-4057qib7 13589 26 all all DT cord-005453-4057qib7 13589 27 affected affect VBN cord-005453-4057qib7 13589 28 siblings sibling NNS cord-005453-4057qib7 13589 29 . . . cord-005453-4057qib7 13590 1 Results result NNS cord-005453-4057qib7 13590 2 : : : cord-005453-4057qib7 13591 1 Due due IN cord-005453-4057qib7 13591 2 to to IN cord-005453-4057qib7 13591 3 the the DT cord-005453-4057qib7 13591 4 severity severity NN cord-005453-4057qib7 13591 5 of of IN cord-005453-4057qib7 13591 6 their -PRON- PRP$ cord-005453-4057qib7 13591 7 disease disease NN cord-005453-4057qib7 13591 8 , , , cord-005453-4057qib7 13591 9 the the DT cord-005453-4057qib7 13591 10 2 2 CD cord-005453-4057qib7 13591 11 oldest old JJS cord-005453-4057qib7 13591 12 siblings sibling NNS cord-005453-4057qib7 13591 13 were be VBD cord-005453-4057qib7 13591 14 transplanted transplant VBN cord-005453-4057qib7 13591 15 first first RB cord-005453-4057qib7 13591 16 using use VBG cord-005453-4057qib7 13591 17 a a DT cord-005453-4057qib7 13591 18 myeloablative myeloablative JJ cord-005453-4057qib7 13591 19 conditioning conditioning NN cord-005453-4057qib7 13591 20 regime regime NN cord-005453-4057qib7 13591 21 of of IN cord-005453-4057qib7 13591 22 Fludarabine Fludarabine NNP cord-005453-4057qib7 13591 23 , , , cord-005453-4057qib7 13591 24 Thiotepa Thiotepa NNP cord-005453-4057qib7 13591 25 and and CC cord-005453-4057qib7 13591 26 Treosulfan Treosulfan NNP cord-005453-4057qib7 13591 27 with with IN cord-005453-4057qib7 13591 28 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 13591 29 . . . cord-005453-4057qib7 13592 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 13592 2 engraftment engraftment NN cord-005453-4057qib7 13592 3 occurred occur VBD cord-005453-4057qib7 13592 4 on on IN cord-005453-4057qib7 13592 5 day day NN cord-005453-4057qib7 13592 6 + + SYM cord-005453-4057qib7 13592 7 11 11 CD cord-005453-4057qib7 13592 8 for for IN cord-005453-4057qib7 13592 9 both both DT cord-005453-4057qib7 13592 10 , , , cord-005453-4057qib7 13592 11 with with IN cord-005453-4057qib7 13592 12 100 100 CD cord-005453-4057qib7 13592 13 % % NN cord-005453-4057qib7 13592 14 donor donor NN cord-005453-4057qib7 13592 15 chimerism chimerism NN cord-005453-4057qib7 13592 16 achieved achieve VBN cord-005453-4057qib7 13592 17 . . . cord-005453-4057qib7 13593 1 There there EX cord-005453-4057qib7 13593 2 were be VBD cord-005453-4057qib7 13593 3 no no DT cord-005453-4057qib7 13593 4 significant significant JJ cord-005453-4057qib7 13593 5 transplant transplant NN cord-005453-4057qib7 13593 6 related relate VBN cord-005453-4057qib7 13593 7 complications complication NNS cord-005453-4057qib7 13593 8 . . . cord-005453-4057qib7 13594 1 The the DT cord-005453-4057qib7 13594 2 post post JJ cord-005453-4057qib7 13594 3 - - JJ cord-005453-4057qib7 13594 4 transplant transplant JJ cord-005453-4057qib7 13594 5 course course NN cord-005453-4057qib7 13594 6 of of IN cord-005453-4057qib7 13594 7 the the DT cord-005453-4057qib7 13594 8 15 15 CD cord-005453-4057qib7 13594 9 year year NN cord-005453-4057qib7 13594 10 old old JJ cord-005453-4057qib7 13594 11 sibling sibling NN cord-005453-4057qib7 13594 12 was be VBD cord-005453-4057qib7 13594 13 complicated complicate VBN cord-005453-4057qib7 13594 14 by by IN cord-005453-4057qib7 13594 15 a a DT cord-005453-4057qib7 13594 16 major major JJ cord-005453-4057qib7 13594 17 stroke stroke NN cord-005453-4057qib7 13594 18 - - HYPH cord-005453-4057qib7 13594 19 like like JJ cord-005453-4057qib7 13594 20 event event NN cord-005453-4057qib7 13594 21 characterised characterise VBN cord-005453-4057qib7 13594 22 by by IN cord-005453-4057qib7 13594 23 dramatic dramatic JJ cord-005453-4057qib7 13594 24 imaging imaging NN cord-005453-4057qib7 13594 25 changes change NNS cord-005453-4057qib7 13594 26 and and CC cord-005453-4057qib7 13594 27 requiring require VBG cord-005453-4057qib7 13594 28 ventilation ventilation NN cord-005453-4057qib7 13594 29 , , , cord-005453-4057qib7 13594 30 though though IN cord-005453-4057qib7 13594 31 no no DT cord-005453-4057qib7 13594 32 cause cause NN cord-005453-4057qib7 13594 33 was be VBD cord-005453-4057qib7 13594 34 identified identify VBN cord-005453-4057qib7 13594 35 and and CC cord-005453-4057qib7 13594 36 the the DT cord-005453-4057qib7 13594 37 patient patient NN cord-005453-4057qib7 13594 38 's 's POS cord-005453-4057qib7 13594 39 neurologic neurologic JJ cord-005453-4057qib7 13594 40 deficits deficit NNS cord-005453-4057qib7 13594 41 have have VBP cord-005453-4057qib7 13594 42 since since IN cord-005453-4057qib7 13594 43 resolved resolve VBN cord-005453-4057qib7 13594 44 . . . cord-005453-4057qib7 13595 1 Gastrointestinal gastrointestinal JJ cord-005453-4057qib7 13595 2 symptoms symptom NNS cord-005453-4057qib7 13595 3 have have VBP cord-005453-4057qib7 13595 4 persisted persist VBN cord-005453-4057qib7 13595 5 and and CC cord-005453-4057qib7 13595 6 both both DT cord-005453-4057qib7 13595 7 remain remain VBP cord-005453-4057qib7 13595 8 TPN TPN NNP cord-005453-4057qib7 13595 9 dependent dependent JJ cord-005453-4057qib7 13595 10 , , , cord-005453-4057qib7 13595 11 though though IN cord-005453-4057qib7 13595 12 symptomatically symptomatically RB cord-005453-4057qib7 13595 13 have have VBP cord-005453-4057qib7 13595 14 shown show VBN cord-005453-4057qib7 13595 15 gradual gradual JJ cord-005453-4057qib7 13595 16 improvement improvement NN cord-005453-4057qib7 13595 17 . . . cord-005453-4057qib7 13596 1 Following follow VBG cord-005453-4057qib7 13596 2 the the DT cord-005453-4057qib7 13596 3 neurologic neurologic JJ cord-005453-4057qib7 13596 4 complications complication NNS cord-005453-4057qib7 13596 5 in in IN cord-005453-4057qib7 13596 6 their -PRON- PRP$ cord-005453-4057qib7 13596 7 older old JJR cord-005453-4057qib7 13596 8 sibling sibling NN cord-005453-4057qib7 13596 9 , , , cord-005453-4057qib7 13596 10 the the DT cord-005453-4057qib7 13596 11 2 2 CD cord-005453-4057qib7 13596 12 younger young JJR cord-005453-4057qib7 13596 13 siblings sibling NNS cord-005453-4057qib7 13596 14 were be VBD cord-005453-4057qib7 13596 15 conditioned condition VBN cord-005453-4057qib7 13596 16 with with IN cord-005453-4057qib7 13596 17 AUC AUC NNP cord-005453-4057qib7 13596 18 - - HYPH cord-005453-4057qib7 13596 19 Targeted target VBN cord-005453-4057qib7 13596 20 Busulfan Busulfan NNP cord-005453-4057qib7 13596 21 and and CC cord-005453-4057qib7 13596 22 fludarabine fludarabine NN cord-005453-4057qib7 13596 23 plus plus CC cord-005453-4057qib7 13596 24 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 13596 25 . . . cord-005453-4057qib7 13597 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 13597 2 engraftment engraftment NN cord-005453-4057qib7 13597 3 occurred occur VBD cord-005453-4057qib7 13597 4 on on IN cord-005453-4057qib7 13597 5 day day NN cord-005453-4057qib7 13597 6 + + SYM cord-005453-4057qib7 13597 7 11 11 CD cord-005453-4057qib7 13597 8 , , , cord-005453-4057qib7 13597 9 with with IN cord-005453-4057qib7 13597 10 full full JJ cord-005453-4057qib7 13597 11 donor donor NN cord-005453-4057qib7 13597 12 chimerism chimerism NN cord-005453-4057qib7 13597 13 achieved achieve VBN cord-005453-4057qib7 13597 14 . . . cord-005453-4057qib7 13598 1 Progression progression NN cord-005453-4057qib7 13598 2 to to IN cord-005453-4057qib7 13598 3 enteral enteral NN cord-005453-4057qib7 13598 4 feeding feeding NN cord-005453-4057qib7 13598 5 has have VBZ cord-005453-4057qib7 13598 6 been be VBN cord-005453-4057qib7 13598 7 much much RB cord-005453-4057qib7 13598 8 more more RBR cord-005453-4057qib7 13598 9 rapid rapid JJ cord-005453-4057qib7 13598 10 , , , cord-005453-4057qib7 13598 11 with with IN cord-005453-4057qib7 13598 12 nutrition nutrition NN cord-005453-4057qib7 13598 13 now now RB cord-005453-4057qib7 13598 14 fully fully RB cord-005453-4057qib7 13598 15 enteral enteral JJ cord-005453-4057qib7 13598 16 for for IN cord-005453-4057qib7 13598 17 both both DT cord-005453-4057qib7 13598 18 . . . cord-005453-4057qib7 13599 1 There there EX cord-005453-4057qib7 13599 2 were be VBD cord-005453-4057qib7 13599 3 no no DT cord-005453-4057qib7 13599 4 significant significant JJ cord-005453-4057qib7 13599 5 transplant transplant NN cord-005453-4057qib7 13599 6 related relate VBN cord-005453-4057qib7 13599 7 complications complication NNS cord-005453-4057qib7 13599 8 . . . cord-005453-4057qib7 13600 1 Conclusions conclusion NNS cord-005453-4057qib7 13600 2 : : : cord-005453-4057qib7 13601 1 Stem Stem NNP cord-005453-4057qib7 13601 2 Cell Cell NNP cord-005453-4057qib7 13601 3 transplantation transplantation NN cord-005453-4057qib7 13601 4 represents represent VBZ cord-005453-4057qib7 13601 5 the the DT cord-005453-4057qib7 13601 6 only only JJ cord-005453-4057qib7 13601 7 curative curative JJ cord-005453-4057qib7 13601 8 option option NN cord-005453-4057qib7 13601 9 for for IN cord-005453-4057qib7 13601 10 MNGIE MNGIE NNP cord-005453-4057qib7 13601 11 . . . cord-005453-4057qib7 13602 1 Due due IN cord-005453-4057qib7 13602 2 to to IN cord-005453-4057qib7 13602 3 its -PRON- PRP$ cord-005453-4057qib7 13602 4 rarity rarity NN cord-005453-4057qib7 13602 5 and and CC cord-005453-4057qib7 13602 6 relative relative JJ cord-005453-4057qib7 13602 7 infancy infancy NN cord-005453-4057qib7 13602 8 as as IN cord-005453-4057qib7 13602 9 a a DT cord-005453-4057qib7 13602 10 condition condition NN cord-005453-4057qib7 13602 11 , , , cord-005453-4057qib7 13602 12 little little JJ cord-005453-4057qib7 13602 13 is be VBZ cord-005453-4057qib7 13602 14 known know VBN cord-005453-4057qib7 13602 15 of of IN cord-005453-4057qib7 13602 16 the the DT cord-005453-4057qib7 13602 17 expected expect VBN cord-005453-4057qib7 13602 18 course course NN cord-005453-4057qib7 13602 19 following follow VBG cord-005453-4057qib7 13602 20 transplant transplant NN cord-005453-4057qib7 13602 21 or or CC cord-005453-4057qib7 13602 22 the the DT cord-005453-4057qib7 13602 23 best good JJS cord-005453-4057qib7 13602 24 approach approach NN cord-005453-4057qib7 13602 25 to to IN cord-005453-4057qib7 13602 26 transplantation transplantation NN cord-005453-4057qib7 13602 27 itself -PRON- PRP cord-005453-4057qib7 13602 28 . . . cord-005453-4057qib7 13603 1 Despite despite IN cord-005453-4057qib7 13603 2 previous previous JJ cord-005453-4057qib7 13603 3 challenges challenge NNS cord-005453-4057qib7 13603 4 with with IN cord-005453-4057qib7 13603 5 graft graft NN cord-005453-4057qib7 13603 6 failure failure NN cord-005453-4057qib7 13603 7 in in IN cord-005453-4057qib7 13603 8 MNGIE MNGIE NNP cord-005453-4057qib7 13603 9 recipients recipient NNS cord-005453-4057qib7 13603 10 , , , cord-005453-4057qib7 13603 11 we -PRON- PRP cord-005453-4057qib7 13603 12 were be VBD cord-005453-4057qib7 13603 13 able able JJ cord-005453-4057qib7 13603 14 to to TO cord-005453-4057qib7 13603 15 gain gain VB cord-005453-4057qib7 13603 16 rapid rapid JJ cord-005453-4057qib7 13603 17 and and CC cord-005453-4057qib7 13603 18 sustained sustained JJ cord-005453-4057qib7 13603 19 donor donor NN cord-005453-4057qib7 13603 20 engraftment engraftment NN cord-005453-4057qib7 13603 21 using use VBG cord-005453-4057qib7 13603 22 2 2 CD cord-005453-4057qib7 13603 23 different different JJ cord-005453-4057qib7 13603 24 myeloablative myeloablative JJ cord-005453-4057qib7 13603 25 conditioning conditioning NN cord-005453-4057qib7 13603 26 regimes regime NNS cord-005453-4057qib7 13603 27 with with IN cord-005453-4057qib7 13603 28 minimal minimal JJ cord-005453-4057qib7 13603 29 transplant transplant NN cord-005453-4057qib7 13603 30 - - HYPH cord-005453-4057qib7 13603 31 related relate VBN cord-005453-4057qib7 13603 32 morbidity morbidity NN cord-005453-4057qib7 13603 33 and and CC cord-005453-4057qib7 13603 34 no no DT cord-005453-4057qib7 13603 35 mortality mortality NN cord-005453-4057qib7 13603 36 . . . cord-005453-4057qib7 13604 1 In in IN cord-005453-4057qib7 13604 2 keeping keep VBG cord-005453-4057qib7 13604 3 with with IN cord-005453-4057qib7 13604 4 previous previous JJ cord-005453-4057qib7 13604 5 reports report NNS cord-005453-4057qib7 13604 6 , , , cord-005453-4057qib7 13604 7 resolution resolution NN cord-005453-4057qib7 13604 8 of of IN cord-005453-4057qib7 13604 9 established establish VBN cord-005453-4057qib7 13604 10 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 13604 11 symptoms symptom NNS cord-005453-4057qib7 13604 12 has have VBZ cord-005453-4057qib7 13604 13 been be VBN cord-005453-4057qib7 13604 14 slow slow JJ cord-005453-4057qib7 13604 15 , , , cord-005453-4057qib7 13604 16 though though IN cord-005453-4057qib7 13604 17 the the DT cord-005453-4057qib7 13604 18 2 2 CD cord-005453-4057qib7 13604 19 siblings sibling NNS cord-005453-4057qib7 13604 20 transplanted transplant VBN cord-005453-4057qib7 13604 21 earlier early RBR cord-005453-4057qib7 13604 22 in in IN cord-005453-4057qib7 13604 23 their -PRON- PRP$ cord-005453-4057qib7 13604 24 disease disease NN cord-005453-4057qib7 13604 25 course course NN cord-005453-4057qib7 13604 26 have have VBP cord-005453-4057qib7 13604 27 shown show VBN cord-005453-4057qib7 13604 28 more more RBR cord-005453-4057qib7 13604 29 rapid rapid JJ cord-005453-4057qib7 13604 30 improvement improvement NN cord-005453-4057qib7 13604 31 supporting support VBG cord-005453-4057qib7 13604 32 the the DT cord-005453-4057qib7 13604 33 role role NN cord-005453-4057qib7 13604 34 of of IN cord-005453-4057qib7 13604 35 early early JJ cord-005453-4057qib7 13604 36 recognition recognition NN cord-005453-4057qib7 13604 37 and and CC cord-005453-4057qib7 13604 38 access access NN cord-005453-4057qib7 13604 39 to to IN cord-005453-4057qib7 13604 40 transplant transplant NN cord-005453-4057qib7 13604 41 . . . cord-005453-4057qib7 13605 1 It -PRON- PRP cord-005453-4057qib7 13605 2 is be VBZ cord-005453-4057qib7 13605 3 essential essential JJ cord-005453-4057qib7 13605 4 moving move VBG cord-005453-4057qib7 13605 5 forward forward RB cord-005453-4057qib7 13605 6 that that IN cord-005453-4057qib7 13605 7 specialised specialised JJ cord-005453-4057qib7 13605 8 transplantation transplantation NN cord-005453-4057qib7 13605 9 centres centre NNS cord-005453-4057qib7 13605 10 collaborate collaborate VBP cord-005453-4057qib7 13605 11 so so IN cord-005453-4057qib7 13605 12 as as IN cord-005453-4057qib7 13605 13 to to TO cord-005453-4057qib7 13605 14 guide guide VB cord-005453-4057qib7 13605 15 clinicians clinician NNS cord-005453-4057qib7 13605 16 in in IN cord-005453-4057qib7 13605 17 the the DT cord-005453-4057qib7 13605 18 management management NN cord-005453-4057qib7 13605 19 of of IN cord-005453-4057qib7 13605 20 such such PDT cord-005453-4057qib7 13605 21 a a DT cord-005453-4057qib7 13605 22 challenging challenging JJ cord-005453-4057qib7 13605 23 condition condition NN cord-005453-4057qib7 13605 24 . . . cord-005453-4057qib7 13606 1 Disclosure disclosure NN cord-005453-4057qib7 13606 2 : : : cord-005453-4057qib7 13606 3 There there EX cord-005453-4057qib7 13606 4 are be VBP cord-005453-4057qib7 13606 5 no no DT cord-005453-4057qib7 13606 6 conflicts conflict NNS cord-005453-4057qib7 13606 7 of of IN cord-005453-4057qib7 13606 8 interest interest NN cord-005453-4057qib7 13606 9 to to TO cord-005453-4057qib7 13606 10 disclose disclose VB cord-005453-4057qib7 13606 11 . . . cord-005453-4057qib7 13607 1 G6PC3 g6pc3 VB cord-005453-4057qib7 13607 2 congenital congenital JJ cord-005453-4057qib7 13608 1 neutropenia neutropenia LS cord-005453-4057qib7 13608 2 -biology -biology : cord-005453-4057qib7 13608 3 of of IN cord-005453-4057qib7 13608 4 inflammatory inflammatory JJ cord-005453-4057qib7 13608 5 colitis colitis NN cord-005453-4057qib7 13608 6 associated associate VBN cord-005453-4057qib7 13608 7 with with IN cord-005453-4057qib7 13608 8 GCSF GCSF NNP cord-005453-4057qib7 13608 9 use use VBP cord-005453-4057qib7 13608 10 , , , cord-005453-4057qib7 13608 11 and and CC cord-005453-4057qib7 13608 12 disease disease NN cord-005453-4057qib7 13608 13 response response NN cord-005453-4057qib7 13608 14 to to IN cord-005453-4057qib7 13608 15 allogeneic allogeneic NN cord-005453-4057qib7 13608 16 transplant transplant NN cord-005453-4057qib7 13608 17 , , , cord-005453-4057qib7 13608 18 a a DT cord-005453-4057qib7 13608 19 report report NN cord-005453-4057qib7 13608 20 of of IN cord-005453-4057qib7 13608 21 4 4 CD cord-005453-4057qib7 13608 22 cases case NNS cord-005453-4057qib7 13608 23 Background background NN cord-005453-4057qib7 13608 24 : : : cord-005453-4057qib7 13609 1 An an DT cord-005453-4057qib7 13609 2 autosomal autosomal JJ cord-005453-4057qib7 13609 3 recessive recessive JJ cord-005453-4057qib7 13609 4 disease disease NN cord-005453-4057qib7 13609 5 , , , cord-005453-4057qib7 13609 6 Glucose-6phosphatase Glucose-6phosphatase NNP cord-005453-4057qib7 13609 7 catalytic catalytic JJ cord-005453-4057qib7 13609 8 subunit subunit NN cord-005453-4057qib7 13609 9 3 3 CD cord-005453-4057qib7 13610 1 ( ( -LRB- cord-005453-4057qib7 13610 2 G6PC3 G6PC3 NNP cord-005453-4057qib7 13610 3 ) ) -RRB- cord-005453-4057qib7 13610 4 deficiency deficiency NN cord-005453-4057qib7 13610 5 is be VBZ cord-005453-4057qib7 13610 6 a a DT cord-005453-4057qib7 13610 7 relatively relatively RB cord-005453-4057qib7 13610 8 recently recently RB cord-005453-4057qib7 13610 9 identified identify VBN cord-005453-4057qib7 13610 10 cause cause NN cord-005453-4057qib7 13610 11 of of IN cord-005453-4057qib7 13610 12 chronic chronic JJ cord-005453-4057qib7 13610 13 severe severe JJ cord-005453-4057qib7 13610 14 neutropenia neutropenia NN cord-005453-4057qib7 13610 15 . . . cord-005453-4057qib7 13611 1 There there EX cord-005453-4057qib7 13611 2 can can MD cord-005453-4057qib7 13611 3 be be VB cord-005453-4057qib7 13611 4 a a DT cord-005453-4057qib7 13611 5 spectrum spectrum NN cord-005453-4057qib7 13611 6 to to IN cord-005453-4057qib7 13611 7 the the DT cord-005453-4057qib7 13611 8 disease disease NN cord-005453-4057qib7 13611 9 and and CC cord-005453-4057qib7 13611 10 patients patient NNS cord-005453-4057qib7 13611 11 may may MD cord-005453-4057qib7 13611 12 also also RB cord-005453-4057qib7 13611 13 present present VB cord-005453-4057qib7 13611 14 with with IN cord-005453-4057qib7 13611 15 non non JJ cord-005453-4057qib7 13611 16 - - JJ cord-005453-4057qib7 13611 17 haematological haematological JJ cord-005453-4057qib7 13611 18 features feature NNS cord-005453-4057qib7 13611 19 including include VBG cord-005453-4057qib7 13611 20 prominent prominent JJ cord-005453-4057qib7 13611 21 chest chest NN cord-005453-4057qib7 13611 22 veins vein NNS cord-005453-4057qib7 13611 23 , , , cord-005453-4057qib7 13611 24 cardiac cardiac NN cord-005453-4057qib7 13611 25 , , , cord-005453-4057qib7 13611 26 endocrine endocrine JJ cord-005453-4057qib7 13611 27 or or CC cord-005453-4057qib7 13611 28 urogenital urogenital JJ cord-005453-4057qib7 13611 29 abnormalities abnormality NNS cord-005453-4057qib7 13611 30 . . . cord-005453-4057qib7 13612 1 We -PRON- PRP cord-005453-4057qib7 13612 2 describe describe VBP cord-005453-4057qib7 13612 3 in in IN cord-005453-4057qib7 13612 4 our -PRON- PRP$ cord-005453-4057qib7 13612 5 patient patient JJ cord-005453-4057qib7 13612 6 cohort cohort NN cord-005453-4057qib7 13612 7 a a DT cord-005453-4057qib7 13612 8 response response NN cord-005453-4057qib7 13612 9 to to IN cord-005453-4057qib7 13612 10 GCSF GCSF NNP cord-005453-4057qib7 13612 11 but but CC cord-005453-4057qib7 13612 12 an an DT cord-005453-4057qib7 13612 13 inflammatory inflammatory JJ cord-005453-4057qib7 13612 14 , , , cord-005453-4057qib7 13612 15 incapacitating incapacitate VBG cord-005453-4057qib7 13612 16 , , , cord-005453-4057qib7 13612 17 biopsyproven biopsyproven NN cord-005453-4057qib7 13612 18 colitis colitis NN cord-005453-4057qib7 13612 19 associated associate VBN cord-005453-4057qib7 13612 20 with with IN cord-005453-4057qib7 13612 21 that that DT cord-005453-4057qib7 13612 22 G G NNP cord-005453-4057qib7 13612 23 - - HYPH cord-005453-4057qib7 13612 24 CSF csf NN cord-005453-4057qib7 13612 25 response response NN cord-005453-4057qib7 13612 26 . . . cord-005453-4057qib7 13613 1 We -PRON- PRP cord-005453-4057qib7 13613 2 have have VBP cord-005453-4057qib7 13613 3 transplanted transplant VBN cord-005453-4057qib7 13613 4 3 3 CD cord-005453-4057qib7 13613 5 children child NNS cord-005453-4057qib7 13613 6 with with IN cord-005453-4057qib7 13613 7 such such JJ cord-005453-4057qib7 13613 8 colitis colitis NN cord-005453-4057qib7 13613 9 , , , cord-005453-4057qib7 13613 10 and and CC cord-005453-4057qib7 13613 11 describe describe VB cord-005453-4057qib7 13613 12 a a DT cord-005453-4057qib7 13613 13 similar similar JJ cord-005453-4057qib7 13613 14 colitis colitis NN cord-005453-4057qib7 13613 15 with with IN cord-005453-4057qib7 13613 16 intestinal intestinal JJ cord-005453-4057qib7 13613 17 failure failure NN cord-005453-4057qib7 13613 18 in in IN cord-005453-4057qib7 13613 19 a a DT cord-005453-4057qib7 13613 20 fourth fourth NN cord-005453-4057qib7 13613 21 . . . cord-005453-4057qib7 13614 1 Methods method NNS cord-005453-4057qib7 13614 2 : : : cord-005453-4057qib7 13615 1 We -PRON- PRP cord-005453-4057qib7 13615 2 investigate investigate VBP cord-005453-4057qib7 13615 3 the the DT cord-005453-4057qib7 13615 4 biology biology NN cord-005453-4057qib7 13615 5 of of IN cord-005453-4057qib7 13615 6 the the DT cord-005453-4057qib7 13615 7 neutropenic neutropenic JJ cord-005453-4057qib7 13615 8 colitis colitis NN cord-005453-4057qib7 13615 9 , , , cord-005453-4057qib7 13615 10 and and CC cord-005453-4057qib7 13615 11 demonstrate demonstrate VB cord-005453-4057qib7 13615 12 necrosis necrosis NN cord-005453-4057qib7 13615 13 of of IN cord-005453-4057qib7 13615 14 the the DT cord-005453-4057qib7 13615 15 stimulated stimulated JJ cord-005453-4057qib7 13615 16 neutrophils neutrophil NNS cord-005453-4057qib7 13615 17 . . . cord-005453-4057qib7 13616 1 In in IN cord-005453-4057qib7 13616 2 vitro vitro FW cord-005453-4057qib7 13616 3 studies study NNS cord-005453-4057qib7 13616 4 demonstrated demonstrate VBD cord-005453-4057qib7 13616 5 that that IN cord-005453-4057qib7 13616 6 unstimulated unstimulated JJ cord-005453-4057qib7 13616 7 neutrophils neutrophil NNS cord-005453-4057qib7 13616 8 from from IN cord-005453-4057qib7 13616 9 patients patient NNS cord-005453-4057qib7 13616 10 with with IN cord-005453-4057qib7 13616 11 G6PC3D G6PC3D NNP cord-005453-4057qib7 13616 12 exhibited exhibit VBD cord-005453-4057qib7 13616 13 significantly significantly RB cord-005453-4057qib7 13616 14 increased increase VBN cord-005453-4057qib7 13616 15 production production NN cord-005453-4057qib7 13616 16 of of IN cord-005453-4057qib7 13616 17 IL8 IL8 NNP cord-005453-4057qib7 13616 18 , , , cord-005453-4057qib7 13616 19 reactive reactive JJ cord-005453-4057qib7 13616 20 oxygen oxygen NN cord-005453-4057qib7 13616 21 species specie NNS cord-005453-4057qib7 13616 22 ( ( -LRB- cord-005453-4057qib7 13616 23 ROS ROS NNP cord-005453-4057qib7 13616 24 ) ) -RRB- cord-005453-4057qib7 13616 25 and and CC cord-005453-4057qib7 13616 26 neutrophil neutrophil NN cord-005453-4057qib7 13616 27 extracellular extracellular JJ cord-005453-4057qib7 13616 28 traps trap NNS cord-005453-4057qib7 13616 29 ( ( -LRB- cord-005453-4057qib7 13616 30 NETs net NNS cord-005453-4057qib7 13616 31 ) ) -RRB- cord-005453-4057qib7 13616 32 alongside alongside IN cord-005453-4057qib7 13616 33 significantly significantly RB cord-005453-4057qib7 13616 34 higher high JJR cord-005453-4057qib7 13616 35 expression expression NN cord-005453-4057qib7 13616 36 of of IN cord-005453-4057qib7 13616 37 CD11b CD11b NNS cord-005453-4057qib7 13616 38 , , , cord-005453-4057qib7 13616 39 CD66b CD66b NNP cord-005453-4057qib7 13616 40 and and CC cord-005453-4057qib7 13616 41 CD14 CD14 NNP cord-005453-4057qib7 13616 42 . . . cord-005453-4057qib7 13617 1 In in IN cord-005453-4057qib7 13617 2 contrast contrast NN cord-005453-4057qib7 13617 3 , , , cord-005453-4057qib7 13617 4 neutrophils neutrophil NNS cord-005453-4057qib7 13617 5 from from IN cord-005453-4057qib7 13617 6 patients patient NNS cord-005453-4057qib7 13617 7 with with IN cord-005453-4057qib7 13617 8 G6PC3D G6PC3D NNP cord-005453-4057qib7 13617 9 produced produce VBD cord-005453-4057qib7 13617 10 significantly significantly RB cord-005453-4057qib7 13617 11 less less JJR cord-005453-4057qib7 13617 12 ROS ROS NNP cord-005453-4057qib7 13617 13 , , , cord-005453-4057qib7 13617 14 MMP-9 MMP-9 NNP cord-005453-4057qib7 13617 15 , , , cord-005453-4057qib7 13617 16 neutrophil neutrophil NN cord-005453-4057qib7 13617 17 elastase elastase NN cord-005453-4057qib7 13617 18 and and CC cord-005453-4057qib7 13617 19 NETs net NNS cord-005453-4057qib7 13617 20 upon upon IN cord-005453-4057qib7 13617 21 stimulation stimulation NN cord-005453-4057qib7 13617 22 . . . cord-005453-4057qib7 13618 1 Neutrophils neutrophils NN cord-005453-4057qib7 13618 2 from from IN cord-005453-4057qib7 13618 3 patients patient NNS cord-005453-4057qib7 13618 4 with with IN cord-005453-4057qib7 13618 5 G6PC3D G6PC3D NNP cord-005453-4057qib7 13618 6 also also RB cord-005453-4057qib7 13618 7 exhibited exhibit VBD cord-005453-4057qib7 13618 8 significantly significantly RB cord-005453-4057qib7 13618 9 accelerated accelerate VBN cord-005453-4057qib7 13618 10 apoptosis apoptosis NN cord-005453-4057qib7 13618 11 and and CC cord-005453-4057qib7 13618 12 secondary secondary JJ cord-005453-4057qib7 13618 13 necrosis necrosis NN cord-005453-4057qib7 13618 14 which which WDT cord-005453-4057qib7 13618 15 was be VBD cord-005453-4057qib7 13618 16 exaggerated exaggerate VBN cord-005453-4057qib7 13618 17 upon upon IN cord-005453-4057qib7 13618 18 stimulation stimulation NN cord-005453-4057qib7 13618 19 with with IN cord-005453-4057qib7 13618 20 live live JJ cord-005453-4057qib7 13618 21 Escherichia escherichia NN cord-005453-4057qib7 13618 22 coli coli NNS cord-005453-4057qib7 13618 23 bacteria bacteria NNS cord-005453-4057qib7 13618 24 but but CC cord-005453-4057qib7 13618 25 could could MD cord-005453-4057qib7 13618 26 only only RB cord-005453-4057qib7 13618 27 be be VB cord-005453-4057qib7 13618 28 partially partially RB cord-005453-4057qib7 13618 29 rescued rescue VBN cord-005453-4057qib7 13618 30 with with IN cord-005453-4057qib7 13618 31 supplemental supplemental JJ cord-005453-4057qib7 13618 32 exogenous exogenous JJ cord-005453-4057qib7 13618 33 glucose glucose NN cord-005453-4057qib7 13618 34 . . . cord-005453-4057qib7 13619 1 Results result NNS cord-005453-4057qib7 13619 2 : : : cord-005453-4057qib7 13620 1 3 3 CD cord-005453-4057qib7 13620 2 patients patient NNS cord-005453-4057qib7 13620 3 have have VBP cord-005453-4057qib7 13620 4 undergone undergo VBN cord-005453-4057qib7 13620 5 HSCT HSCT NNP cord-005453-4057qib7 13620 6 for for IN cord-005453-4057qib7 13620 7 G6PC3 G6PC3 NNP cord-005453-4057qib7 13620 8 neutropenic neutropenic JJ cord-005453-4057qib7 13620 9 enterocolitis enterocolitis NN cord-005453-4057qib7 13620 10 ( ( -LRB- cord-005453-4057qib7 13620 11 1 1 CD cord-005453-4057qib7 13620 12 unrelated unrelated JJ cord-005453-4057qib7 13620 13 donor donor NN cord-005453-4057qib7 13620 14 and and CC cord-005453-4057qib7 13620 15 2 2 CD cord-005453-4057qib7 13620 16 MSD MSD NNP cord-005453-4057qib7 13620 17 ) ) -RRB- cord-005453-4057qib7 13620 18 after after IN cord-005453-4057qib7 13620 19 Fludarabine Fludarabine NNP cord-005453-4057qib7 13620 20 treosulfan treosulfan NNP cord-005453-4057qib7 13620 21 and and CC cord-005453-4057qib7 13620 22 thiotepa thiotepa JJ cord-005453-4057qib7 13620 23 conditioning conditioning NN cord-005453-4057qib7 13620 24 therapy therapy NN cord-005453-4057qib7 13620 25 . . . cord-005453-4057qib7 13621 1 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 13621 2 was be VBD cord-005453-4057qib7 13621 3 given give VBN cord-005453-4057qib7 13621 4 as as IN cord-005453-4057qib7 13621 5 as as IN cord-005453-4057qib7 13621 6 serotherapy serotherapy NNP cord-005453-4057qib7 13621 7 . . . cord-005453-4057qib7 13622 1 All all DT cord-005453-4057qib7 13622 2 3 3 CD cord-005453-4057qib7 13622 3 patients patient NNS cord-005453-4057qib7 13622 4 are be VBP cord-005453-4057qib7 13622 5 alive alive JJ cord-005453-4057qib7 13622 6 and and CC cord-005453-4057qib7 13622 7 well well RB cord-005453-4057qib7 13622 8 , , , cord-005453-4057qib7 13622 9 immune immune JJ cord-005453-4057qib7 13622 10 suppression suppression NN cord-005453-4057qib7 13622 11 has have VBZ cord-005453-4057qib7 13622 12 been be VBN cord-005453-4057qib7 13622 13 discotniuned discotniune VBN cord-005453-4057qib7 13622 14 and and CC cord-005453-4057qib7 13622 15 there there EX cord-005453-4057qib7 13622 16 is be VBZ cord-005453-4057qib7 13622 17 no no DT cord-005453-4057qib7 13622 18 GVHD gvhd NN cord-005453-4057qib7 13622 19 with with IN cord-005453-4057qib7 13622 20 normal normal JJ cord-005453-4057qib7 13622 21 organ organ NN cord-005453-4057qib7 13622 22 function function NN cord-005453-4057qib7 13622 23 , , , cord-005453-4057qib7 13622 24 and and CC cord-005453-4057qib7 13622 25 resolution resolution NN cord-005453-4057qib7 13622 26 of of IN cord-005453-4057qib7 13622 27 colitis colitis NN cord-005453-4057qib7 13622 28 . . . cord-005453-4057qib7 13623 1 We -PRON- PRP cord-005453-4057qib7 13623 2 describe describe VBP cord-005453-4057qib7 13623 3 a a DT cord-005453-4057qib7 13623 4 4 4 CD cord-005453-4057qib7 13623 5 th th XX cord-005453-4057qib7 13623 6 patient patient NN cord-005453-4057qib7 13623 7 with with IN cord-005453-4057qib7 13623 8 no no DT cord-005453-4057qib7 13623 9 good good JJ cord-005453-4057qib7 13623 10 donor donor NN cord-005453-4057qib7 13623 11 who who WP cord-005453-4057qib7 13623 12 has have VBZ cord-005453-4057qib7 13623 13 continuing continue VBG cord-005453-4057qib7 13623 14 intestinal intestinal JJ cord-005453-4057qib7 13623 15 failure failure NN cord-005453-4057qib7 13623 16 with with IN cord-005453-4057qib7 13623 17 G G NNP cord-005453-4057qib7 13623 18 - - HYPH cord-005453-4057qib7 13623 19 CSF CSF NNP cord-005453-4057qib7 13623 20 use use NN cord-005453-4057qib7 13623 21 . . . cord-005453-4057qib7 13624 1 Conclusions conclusion NNS cord-005453-4057qib7 13624 2 : : : cord-005453-4057qib7 13625 1 We -PRON- PRP cord-005453-4057qib7 13625 2 describe describe VBP cord-005453-4057qib7 13625 3 the the DT cord-005453-4057qib7 13625 4 aetiology aetiology NN cord-005453-4057qib7 13625 5 of of IN cord-005453-4057qib7 13625 6 intestinal intestinal JJ cord-005453-4057qib7 13625 7 inflammation inflammation NN cord-005453-4057qib7 13625 8 and and CC cord-005453-4057qib7 13625 9 failure failure NN cord-005453-4057qib7 13625 10 with with IN cord-005453-4057qib7 13625 11 an an DT cord-005453-4057qib7 13625 12 extensive extensive JJ cord-005453-4057qib7 13625 13 study study NN cord-005453-4057qib7 13625 14 of of IN cord-005453-4057qib7 13625 15 neutrophil neutrophil NN cord-005453-4057qib7 13625 16 biology biology NN cord-005453-4057qib7 13625 17 in in IN cord-005453-4057qib7 13625 18 this this DT cord-005453-4057qib7 13625 19 metabolic metabolic JJ cord-005453-4057qib7 13625 20 neutropenia neutropenia NN cord-005453-4057qib7 13625 21 . . . cord-005453-4057qib7 13626 1 We -PRON- PRP cord-005453-4057qib7 13626 2 describe describe VBP cord-005453-4057qib7 13626 3 a a DT cord-005453-4057qib7 13626 4 novel novel JJ cord-005453-4057qib7 13626 5 indication indication NN cord-005453-4057qib7 13626 6 for for IN cord-005453-4057qib7 13626 7 HSCT HSCT NNP cord-005453-4057qib7 13626 8 in in IN cord-005453-4057qib7 13626 9 this this DT cord-005453-4057qib7 13626 10 " " `` cord-005453-4057qib7 13626 11 G g NN cord-005453-4057qib7 13626 12 - - HYPH cord-005453-4057qib7 13626 13 CSFresponsive csfresponsive NN cord-005453-4057qib7 13626 14 neutropenia neutropenia NN cord-005453-4057qib7 13626 15 " " '' cord-005453-4057qib7 13626 16 . . . cord-005453-4057qib7 13627 1 Disclosure disclosure NN cord-005453-4057qib7 13627 2 : : : cord-005453-4057qib7 13627 3 Nothing nothing NN cord-005453-4057qib7 13627 4 to to TO cord-005453-4057qib7 13627 5 declare declare VB cord-005453-4057qib7 13627 6 P620 P620 NNP cord-005453-4057qib7 13627 7 Does do VBZ cord-005453-4057qib7 13627 8 body body VB cord-005453-4057qib7 13627 9 mass mass NN cord-005453-4057qib7 13627 10 index index NN cord-005453-4057qib7 13627 11 ( ( -LRB- cord-005453-4057qib7 13627 12 BMI BMI NNP cord-005453-4057qib7 13627 13 ) ) -RRB- cord-005453-4057qib7 13627 14 pose pose VBP cord-005453-4057qib7 13627 15 a a DT cord-005453-4057qib7 13627 16 risk risk NN cord-005453-4057qib7 13627 17 to to TO cord-005453-4057qib7 13627 18 outcome outcome VB cord-005453-4057qib7 13627 19 for for IN cord-005453-4057qib7 13627 20 pediatric pediatric JJ cord-005453-4057qib7 13627 21 non non JJ cord-005453-4057qib7 13627 22 - - JJ cord-005453-4057qib7 13627 23 infantile infantile JJ cord-005453-4057qib7 13627 24 patients patient NNS cord-005453-4057qib7 13627 25 undergoing undergo VBG cord-005453-4057qib7 13627 26 hematopoietic hematopoietic JJ cord-005453-4057qib7 13627 27 cell cell NN cord-005453-4057qib7 13627 28 transplantation transplantation NN cord-005453-4057qib7 13627 29 ( ( -LRB- cord-005453-4057qib7 13627 30 HSCT HSCT NNP cord-005453-4057qib7 13627 31 ) ) -RRB- cord-005453-4057qib7 13627 32 ? ? . cord-005453-4057qib7 13628 1 Mona Mona NNP cord-005453-4057qib7 13628 2 Al Al NNP cord-005453-4057qib7 13628 3 - - HYPH cord-005453-4057qib7 13628 4 Saleh Saleh NNP cord-005453-4057qib7 13628 5 1 1 CD cord-005453-4057qib7 13628 6 , , , cord-005453-4057qib7 13628 7 Khawar Khawar NNP cord-005453-4057qib7 13628 8 Siddiqui Siddiqui NNP cord-005453-4057qib7 13628 9 1 1 CD cord-005453-4057qib7 13628 10 , , , cord-005453-4057qib7 13628 11 Amal Amal NNP cord-005453-4057qib7 13628 12 Al Al NNP cord-005453-4057qib7 13628 13 - - HYPH cord-005453-4057qib7 13628 14 Seraihy Seraihy NNP cord-005453-4057qib7 13628 15 1 1 CD cord-005453-4057qib7 13628 16 , , , cord-005453-4057qib7 13628 17 Abdullah Abdullah NNP cord-005453-4057qib7 13628 18 Al Al NNP cord-005453-4057qib7 13628 19 - - HYPH cord-005453-4057qib7 13628 20 Jefri Jefri NNP cord-005453-4057qib7 13628 21 1 1 CD cord-005453-4057qib7 13628 22 , , , cord-005453-4057qib7 13628 23 Ali Ali NNP cord-005453-4057qib7 13628 24 Al Al NNP cord-005453-4057qib7 13628 25 - - HYPH cord-005453-4057qib7 13628 26 Ahmari Ahmari NNP cord-005453-4057qib7 13628 27 1 1 CD cord-005453-4057qib7 13628 28 , , , cord-005453-4057qib7 13628 29 Hawazen Hawazen NNP cord-005453-4057qib7 13628 30 Al Al NNP cord-005453-4057qib7 13628 31 - - HYPH cord-005453-4057qib7 13628 32 Saedi Saedi NNP cord-005453-4057qib7 13628 33 1 1 CD cord-005453-4057qib7 13628 34 , , , cord-005453-4057qib7 13628 35 Awatif Awatif NNP cord-005453-4057qib7 13628 36 Al Al NNP cord-005453-4057qib7 13628 37 - - HYPH cord-005453-4057qib7 13628 38 Anazi Anazi NNP cord-005453-4057qib7 13628 39 1 1 CD cord-005453-4057qib7 13628 40 , , , cord-005453-4057qib7 13628 41 Mouhab Mouhab NNP cord-005453-4057qib7 13628 42 Ayas Ayas NNP cord-005453-4057qib7 13628 43 1 1 CD cord-005453-4057qib7 13628 44 , , , cord-005453-4057qib7 13628 45 Ibrahim Ibrahim NNP cord-005453-4057qib7 13628 46 Al Al NNP cord-005453-4057qib7 13628 47 - - HYPH cord-005453-4057qib7 13628 48 Ghemlas Ghemlas NNP cord-005453-4057qib7 13628 49 1 1 CD cord-005453-4057qib7 13629 1 with with IN cord-005453-4057qib7 13629 2 no no DT cord-005453-4057qib7 13629 3 evidence evidence NN cord-005453-4057qib7 13629 4 of of IN cord-005453-4057qib7 13629 5 toxicity toxicity NN cord-005453-4057qib7 13629 6 . . . cord-005453-4057qib7 13630 1 As as IN cord-005453-4057qib7 13630 2 benefits benefit NNS cord-005453-4057qib7 13630 3 of of IN cord-005453-4057qib7 13630 4 Stoss Stoss NNP cord-005453-4057qib7 13630 5 therapy therapy NN cord-005453-4057qib7 13630 6 in in IN cord-005453-4057qib7 13630 7 HSCT HSCT NNP cord-005453-4057qib7 13630 8 remain remain VBP cord-005453-4057qib7 13630 9 unknown unknown JJ cord-005453-4057qib7 13630 10 , , , cord-005453-4057qib7 13630 11 and and CC cord-005453-4057qib7 13630 12 safety safety NN cord-005453-4057qib7 13630 13 has have VBZ cord-005453-4057qib7 13630 14 yet yet RB cord-005453-4057qib7 13630 15 to to TO cord-005453-4057qib7 13630 16 have have VB cord-005453-4057qib7 13630 17 been be VBN cord-005453-4057qib7 13630 18 studied study VBN cord-005453-4057qib7 13630 19 extensively extensively RB cord-005453-4057qib7 13630 20 in in IN cord-005453-4057qib7 13630 21 the the DT cord-005453-4057qib7 13630 22 pediatric pediatric JJ cord-005453-4057qib7 13630 23 population population NN cord-005453-4057qib7 13630 24 , , , cord-005453-4057qib7 13630 25 we -PRON- PRP cord-005453-4057qib7 13630 26 hypothesize hypothesize VBP cord-005453-4057qib7 13630 27 that that IN cord-005453-4057qib7 13630 28 Stoss Stoss NNP cord-005453-4057qib7 13630 29 therapy therapy NN cord-005453-4057qib7 13630 30 is be VBZ cord-005453-4057qib7 13630 31 an an DT cord-005453-4057qib7 13630 32 effective effective JJ cord-005453-4057qib7 13630 33 and and CC cord-005453-4057qib7 13630 34 safe safe JJ cord-005453-4057qib7 13630 35 method method NN cord-005453-4057qib7 13630 36 to to TO cord-005453-4057qib7 13630 37 reach reach VB cord-005453-4057qib7 13630 38 and and CC cord-005453-4057qib7 13630 39 attain attain VB cord-005453-4057qib7 13630 40 sufficient sufficient JJ cord-005453-4057qib7 13630 41 levels level NNS cord-005453-4057qib7 13630 42 of of IN cord-005453-4057qib7 13630 43 VD vd NN cord-005453-4057qib7 13630 44 in in IN cord-005453-4057qib7 13630 45 pediatric pediatric JJ cord-005453-4057qib7 13630 46 patients patient NNS cord-005453-4057qib7 13630 47 undergoing undergo VBG cord-005453-4057qib7 13630 48 HSCT HSCT NNP cord-005453-4057qib7 13630 49 . . . cord-005453-4057qib7 13631 1 Methods method NNS cord-005453-4057qib7 13631 2 : : : cord-005453-4057qib7 13631 3 This this DT cord-005453-4057qib7 13631 4 is be VBZ cord-005453-4057qib7 13631 5 an an DT cord-005453-4057qib7 13631 6 ongoing ongoing JJ cord-005453-4057qib7 13631 7 prospective prospective NN cord-005453-4057qib7 13631 8 , , , cord-005453-4057qib7 13631 9 randomized randomized JJ cord-005453-4057qib7 13631 10 clinical clinical JJ cord-005453-4057qib7 13631 11 control control NN cord-005453-4057qib7 13631 12 trial trial NN cord-005453-4057qib7 13631 13 at at IN cord-005453-4057qib7 13631 14 Phoenix Phoenix NNP cord-005453-4057qib7 13631 15 Children Children NNP cord-005453-4057qib7 13631 16 's 's POS cord-005453-4057qib7 13631 17 Hospital Hospital NNP cord-005453-4057qib7 13631 18 that that WDT cord-005453-4057qib7 13631 19 commenced commence VBD cord-005453-4057qib7 13631 20 December December NNP cord-005453-4057qib7 13631 21 1 1 CD cord-005453-4057qib7 13631 22 st st NNP cord-005453-4057qib7 13631 23 , , , cord-005453-4057qib7 13631 24 2017 2017 CD cord-005453-4057qib7 13631 25 . . . cord-005453-4057qib7 13632 1 Following follow VBG cord-005453-4057qib7 13632 2 consent consent NN cord-005453-4057qib7 13632 3 , , , cord-005453-4057qib7 13632 4 subjects subject NNS cord-005453-4057qib7 13632 5 are be VBP cord-005453-4057qib7 13632 6 randomized randomize VBN cord-005453-4057qib7 13632 7 to to IN cord-005453-4057qib7 13632 8 the the DT cord-005453-4057qib7 13632 9 intervention intervention NN cord-005453-4057qib7 13632 10 ( ( -LRB- cord-005453-4057qib7 13632 11 Stoss Stoss NNP cord-005453-4057qib7 13632 12 ) ) -RRB- cord-005453-4057qib7 13632 13 or or CC cord-005453-4057qib7 13632 14 control control NN cord-005453-4057qib7 13632 15 arm arm NN cord-005453-4057qib7 13632 16 prior prior RB cord-005453-4057qib7 13632 17 to to IN cord-005453-4057qib7 13632 18 HSCT HSCT NNP cord-005453-4057qib7 13632 19 . . . cord-005453-4057qib7 13633 1 Stoss Stoss NNP cord-005453-4057qib7 13633 2 therapy therapy NN cord-005453-4057qib7 13633 3 consists consist VBZ cord-005453-4057qib7 13633 4 of of IN cord-005453-4057qib7 13633 5 a a DT cord-005453-4057qib7 13633 6 single single JJ cord-005453-4057qib7 13633 7 oral oral JJ cord-005453-4057qib7 13633 8 dose dose NN cord-005453-4057qib7 13633 9 of of IN cord-005453-4057qib7 13633 10 VD VD NNP cord-005453-4057qib7 13633 11 ( ( -LRB- cord-005453-4057qib7 13633 12 ranging range VBG cord-005453-4057qib7 13633 13 100,000IU 100,000iu CD cord-005453-4057qib7 13633 14 -600,000IU -600,000IU NFP cord-005453-4057qib7 13633 15 ) ) -RRB- cord-005453-4057qib7 13633 16 , , , cord-005453-4057qib7 13633 17 given give VBN cord-005453-4057qib7 13633 18 based base VBN cord-005453-4057qib7 13633 19 on on IN cord-005453-4057qib7 13633 20 baseline baseline JJ cord-005453-4057qib7 13633 21 25-hydroxyvitamin 25-hydroxyvitamin CD cord-005453-4057qib7 13633 22 D d NN cord-005453-4057qib7 13633 23 [ [ -LRB- cord-005453-4057qib7 13633 24 25(OH)D 25(oh)d CD cord-005453-4057qib7 13633 25 ] ] -RRB- cord-005453-4057qib7 13633 26 level level NN cord-005453-4057qib7 13633 27 and and CC cord-005453-4057qib7 13633 28 age age NN cord-005453-4057qib7 13633 29 , , , cord-005453-4057qib7 13633 30 followed follow VBN cord-005453-4057qib7 13633 31 by by IN cord-005453-4057qib7 13633 32 standard standard JJ cord-005453-4057qib7 13633 33 weekly weekly JJ cord-005453-4057qib7 13633 34 supplementation supplementation NN cord-005453-4057qib7 13633 35 . . . cord-005453-4057qib7 13634 1 Subjects subject NNS cord-005453-4057qib7 13634 2 enrolled enrol VBN cord-005453-4057qib7 13634 3 on on IN cord-005453-4057qib7 13634 4 the the DT cord-005453-4057qib7 13634 5 control control NN cord-005453-4057qib7 13634 6 arm arm NN cord-005453-4057qib7 13634 7 receive receive VB cord-005453-4057qib7 13634 8 standard standard NN cord-005453-4057qib7 13634 9 of of IN cord-005453-4057qib7 13634 10 care care NN cord-005453-4057qib7 13634 11 based base VBN cord-005453-4057qib7 13634 12 on on IN cord-005453-4057qib7 13634 13 Endocrine Endocrine NNP cord-005453-4057qib7 13634 14 Society Society NNP cord-005453-4057qib7 13634 15 Guidelines Guidelines NNPS cord-005453-4057qib7 13634 16 of of IN cord-005453-4057qib7 13634 17 weekly weekly JJ cord-005453-4057qib7 13634 18 VD VD NNP cord-005453-4057qib7 13634 19 supplementation supplementation NN cord-005453-4057qib7 13634 20 . . . cord-005453-4057qib7 13635 1 Data Data NNP cord-005453-4057qib7 13635 2 collection collection NN cord-005453-4057qib7 13635 3 includes include VBZ cord-005453-4057qib7 13635 4 demographics demographic NNS cord-005453-4057qib7 13635 5 , , , cord-005453-4057qib7 13635 6 25(OH)D 25(oh)d CD cord-005453-4057qib7 13635 7 levels level NNS cord-005453-4057qib7 13635 8 at at IN cord-005453-4057qib7 13635 9 baseline baseline NN cord-005453-4057qib7 13635 10 , , , cord-005453-4057qib7 13635 11 day day NN cord-005453-4057qib7 13635 12 +30 +30 CD cord-005453-4057qib7 13635 13 , , , cord-005453-4057qib7 13635 14 and and CC cord-005453-4057qib7 13635 15 day day NN cord-005453-4057qib7 13635 16 +100 +100 NNS cord-005453-4057qib7 13635 17 , , , cord-005453-4057qib7 13635 18 VD VD NNP cord-005453-4057qib7 13635 19 toxicity toxicity NN cord-005453-4057qib7 13635 20 ( ( -LRB- cord-005453-4057qib7 13635 21 hyperphosphatemia hyperphosphatemia NN cord-005453-4057qib7 13635 22 , , , cord-005453-4057qib7 13635 23 hyperkalemia hyperkalemia NN cord-005453-4057qib7 13635 24 and and CC cord-005453-4057qib7 13635 25 renal renal JJ cord-005453-4057qib7 13635 26 calculi calculus NNS cord-005453-4057qib7 13635 27 ) ) -RRB- cord-005453-4057qib7 13635 28 , , , cord-005453-4057qib7 13635 29 as as IN cord-005453-4057qib7 13635 30 well well RB cord-005453-4057qib7 13635 31 comorbidities comorbiditie NNS cord-005453-4057qib7 13635 32 were be VBD cord-005453-4057qib7 13635 33 collected collect VBN cord-005453-4057qib7 13635 34 . . . cord-005453-4057qib7 13636 1 At at IN cord-005453-4057qib7 13636 2 each each DT cord-005453-4057qib7 13636 3 time time NN cord-005453-4057qib7 13636 4 point point NN cord-005453-4057qib7 13636 5 and and CC cord-005453-4057qib7 13636 6 for for IN cord-005453-4057qib7 13636 7 each each DT cord-005453-4057qib7 13636 8 trial trial NN cord-005453-4057qib7 13636 9 arm arm NN cord-005453-4057qib7 13636 10 , , , cord-005453-4057qib7 13636 11 the the DT cord-005453-4057qib7 13636 12 mean mean JJ cord-005453-4057qib7 13636 13 25(OH)D 25(oh)d CD cord-005453-4057qib7 13636 14 level level NN cord-005453-4057qib7 13636 15 and and CC cord-005453-4057qib7 13636 16 changes change NNS cord-005453-4057qib7 13636 17 from from IN cord-005453-4057qib7 13636 18 baseline baseline NN cord-005453-4057qib7 13636 19 were be VBD cord-005453-4057qib7 13636 20 computed compute VBN cord-005453-4057qib7 13636 21 with with IN cord-005453-4057qib7 13636 22 corresponding correspond VBG cord-005453-4057qib7 13636 23 95 95 CD cord-005453-4057qib7 13636 24 % % NN cord-005453-4057qib7 13636 25 confidence confidence NN cord-005453-4057qib7 13636 26 intervals interval NNS cord-005453-4057qib7 13636 27 ( ( -LRB- cord-005453-4057qib7 13636 28 CIs CIs NNP cord-005453-4057qib7 13636 29 ) ) -RRB- cord-005453-4057qib7 13636 30 to to TO cord-005453-4057qib7 13636 31 indicate indicate VB cord-005453-4057qib7 13636 32 variability variability NN cord-005453-4057qib7 13636 33 . . . cord-005453-4057qib7 13637 1 Results result NNS cord-005453-4057qib7 13637 2 : : : cord-005453-4057qib7 13637 3 Presently presently RB cord-005453-4057qib7 13637 4 , , , cord-005453-4057qib7 13637 5 12 12 CD cord-005453-4057qib7 13637 6 subjects subject NNS cord-005453-4057qib7 13637 7 have have VBP cord-005453-4057qib7 13637 8 completed complete VBN cord-005453-4057qib7 13637 9 baseline baseline JJ cord-005453-4057qib7 13637 10 assessment assessment NN cord-005453-4057qib7 13637 11 , , , cord-005453-4057qib7 13637 12 with with IN cord-005453-4057qib7 13637 13 Day day NN cord-005453-4057qib7 13637 14 +30 +30 CD cord-005453-4057qib7 13637 15 and and CC cord-005453-4057qib7 13637 16 Day day NN cord-005453-4057qib7 13637 17 +100 +100 NNS cord-005453-4057qib7 13637 18 follow follow NN cord-005453-4057qib7 13637 19 - - HYPH cord-005453-4057qib7 13637 20 up up NN cord-005453-4057qib7 13637 21 completed complete VBD cord-005453-4057qib7 13637 22 for for IN cord-005453-4057qib7 13637 23 11 11 CD cord-005453-4057qib7 13637 24 and and CC cord-005453-4057qib7 13637 25 9 9 CD cord-005453-4057qib7 13637 26 of of IN cord-005453-4057qib7 13637 27 these these DT cord-005453-4057qib7 13637 28 , , , cord-005453-4057qib7 13637 29 respectively respectively RB cord-005453-4057qib7 13637 30 . . . cord-005453-4057qib7 13638 1 At at IN cord-005453-4057qib7 13638 2 baseline baseline NN cord-005453-4057qib7 13638 3 , , , cord-005453-4057qib7 13638 4 the the DT cord-005453-4057qib7 13638 5 mean mean NN cord-005453-4057qib7 13638 6 ( ( -LRB- cord-005453-4057qib7 13638 7 95 95 CD cord-005453-4057qib7 13638 8 % % NN cord-005453-4057qib7 13638 9 CI CI NNP cord-005453-4057qib7 13638 10 ) ) -RRB- cord-005453-4057qib7 13638 11 25(OH)D 25(oh)d CD cord-005453-4057qib7 13638 12 was be VBD cord-005453-4057qib7 13638 13 19.8 19.8 CD cord-005453-4057qib7 13638 14 ng ng NNP cord-005453-4057qib7 13638 15 / / SYM cord-005453-4057qib7 13638 16 dl dl NNP cord-005453-4057qib7 13638 17 ( ( -LRB- cord-005453-4057qib7 13638 18 10.9 10.9 CD cord-005453-4057qib7 13638 19 , , , cord-005453-4057qib7 13638 20 28.7 28.7 CD cord-005453-4057qib7 13638 21 ) ) -RRB- cord-005453-4057qib7 13638 22 among among IN cord-005453-4057qib7 13638 23 Stoss Stoss NNP cord-005453-4057qib7 13638 24 patients patient NNS cord-005453-4057qib7 13638 25 and and CC cord-005453-4057qib7 13638 26 18.9 18.9 CD cord-005453-4057qib7 13638 27 ng ng NNP cord-005453-4057qib7 13638 28 / / SYM cord-005453-4057qib7 13638 29 dl dl NNP cord-005453-4057qib7 13638 30 ( ( -LRB- cord-005453-4057qib7 13638 31 10 10 CD cord-005453-4057qib7 13638 32 . . . cord-005453-4057qib7 13639 1 3 3 CD cord-005453-4057qib7 13639 2 Results result NNS cord-005453-4057qib7 13639 3 : : : cord-005453-4057qib7 13639 4 Total total JJ cord-005453-4057qib7 13639 5 HRQoL HRQoL NNP cord-005453-4057qib7 13639 6 scores score NNS cord-005453-4057qib7 13639 7 of of IN cord-005453-4057qib7 13639 8 transplanted transplant VBN cord-005453-4057qib7 13639 9 patients patient NNS cord-005453-4057qib7 13639 10 were be VBD cord-005453-4057qib7 13639 11 significantly significantly RB cord-005453-4057qib7 13639 12 improved improve VBN cord-005453-4057qib7 13639 13 compared compare VBN cord-005453-4057qib7 13639 14 to to IN cord-005453-4057qib7 13639 15 those those DT cord-005453-4057qib7 13639 16 on on IN cord-005453-4057qib7 13639 17 supportive supportive JJ cord-005453-4057qib7 13639 18 care care NN cord-005453-4057qib7 13639 19 and and CC cord-005453-4057qib7 13639 20 also also RB cord-005453-4057qib7 13639 21 compared compare VBN cord-005453-4057qib7 13639 22 to to IN cord-005453-4057qib7 13639 23 healthy healthy JJ cord-005453-4057qib7 13639 24 siblings sibling NNS cord-005453-4057qib7 13639 25 ( ( -LRB- cord-005453-4057qib7 13639 26 P p NN cord-005453-4057qib7 13639 27 < < XX cord-005453-4057qib7 13639 28 0.0001 0.0001 CD cord-005453-4057qib7 13639 29 and and CC cord-005453-4057qib7 13639 30 0.0002 0.0002 CD cord-005453-4057qib7 13639 31 respectively respectively RB cord-005453-4057qib7 13639 32 ) ) -RRB- cord-005453-4057qib7 13639 33 , , , cord-005453-4057qib7 13639 34 the the DT cord-005453-4057qib7 13639 35 same same JJ cord-005453-4057qib7 13639 36 was be VBD cord-005453-4057qib7 13639 37 true true JJ cord-005453-4057qib7 13639 38 for for IN cord-005453-4057qib7 13639 39 physical physical JJ cord-005453-4057qib7 13639 40 ( ( -LRB- cord-005453-4057qib7 13639 41 P p NN cord-005453-4057qib7 13639 42 < < XX cord-005453-4057qib7 13639 43 0.0001 0.0001 CD cord-005453-4057qib7 13639 44 and and CC cord-005453-4057qib7 13639 45 0.0003 0.0003 CD cord-005453-4057qib7 13639 46 respectively respectively RB cord-005453-4057qib7 13639 47 ) ) -RRB- cord-005453-4057qib7 13639 48 and and CC cord-005453-4057qib7 13639 49 emotional emotional JJ cord-005453-4057qib7 13639 50 functioning functioning NN cord-005453-4057qib7 13639 51 ( ( -LRB- cord-005453-4057qib7 13639 52 P p NN cord-005453-4057qib7 13639 53 < < XX cord-005453-4057qib7 13639 54 0.0001 0.0001 CD cord-005453-4057qib7 13639 55 and and CC cord-005453-4057qib7 13639 56 0.0073 0.0073 CD cord-005453-4057qib7 13639 57 respectively respectively RB cord-005453-4057qib7 13639 58 ) ) -RRB- cord-005453-4057qib7 13639 59 . . . cord-005453-4057qib7 13640 1 Social social JJ cord-005453-4057qib7 13640 2 and and CC cord-005453-4057qib7 13640 3 school school NN cord-005453-4057qib7 13640 4 functioning functioning NN cord-005453-4057qib7 13640 5 of of IN cord-005453-4057qib7 13640 6 transplanted transplanted JJ cord-005453-4057qib7 13640 7 children child NNS cord-005453-4057qib7 13640 8 were be VBD cord-005453-4057qib7 13640 9 not not RB cord-005453-4057qib7 13640 10 different different JJ cord-005453-4057qib7 13640 11 from from IN cord-005453-4057qib7 13640 12 healthy healthy JJ cord-005453-4057qib7 13640 13 siblings sibling NNS cord-005453-4057qib7 13640 14 ( ( -LRB- cord-005453-4057qib7 13640 15 P p NN cord-005453-4057qib7 13640 16 0.5893 0.5893 CD cord-005453-4057qib7 13640 17 and and CC cord-005453-4057qib7 13640 18 0.7603 0.7603 CD cord-005453-4057qib7 13640 19 respectively respectively RB cord-005453-4057qib7 13640 20 ) ) -RRB- cord-005453-4057qib7 13640 21 while while IN cord-005453-4057qib7 13640 22 were be VBD cord-005453-4057qib7 13640 23 very very RB cord-005453-4057qib7 13640 24 significantly significantly RB cord-005453-4057qib7 13640 25 improved improve VBN cord-005453-4057qib7 13640 26 compared compare VBN cord-005453-4057qib7 13640 27 to to IN cord-005453-4057qib7 13640 28 children child NNS cord-005453-4057qib7 13640 29 with with IN cord-005453-4057qib7 13640 30 ST ST NNP cord-005453-4057qib7 13640 31 on on IN cord-005453-4057qib7 13640 32 supportive supportive JJ cord-005453-4057qib7 13640 33 care care NN cord-005453-4057qib7 13641 1 ( ( -LRB- cord-005453-4057qib7 13641 2 P p NN cord-005453-4057qib7 13641 3 < < XX cord-005453-4057qib7 13641 4 0.0001 0.0001 CD cord-005453-4057qib7 13641 5 in in IN cord-005453-4057qib7 13641 6 both both DT cord-005453-4057qib7 13641 7 cases case NNS cord-005453-4057qib7 13641 8 ) ) -RRB- cord-005453-4057qib7 13641 9 . . . cord-005453-4057qib7 13642 1 Conclusions conclusion NNS cord-005453-4057qib7 13642 2 : : : cord-005453-4057qib7 13642 3 BMT BMT NNP cord-005453-4057qib7 13642 4 in in IN cord-005453-4057qib7 13642 5 a a DT cord-005453-4057qib7 13642 6 lower low JJR cord-005453-4057qib7 13642 7 - - HYPH cord-005453-4057qib7 13642 8 middle middle JJ cord-005453-4057qib7 13642 9 income income NN cord-005453-4057qib7 13642 10 setting setting NN cord-005453-4057qib7 13642 11 may may MD cord-005453-4057qib7 13642 12 be be VB cord-005453-4057qib7 13642 13 even even RB cord-005453-4057qib7 13642 14 more more RBR cord-005453-4057qib7 13642 15 impactful impactful JJ cord-005453-4057qib7 13642 16 compared compare VBN cord-005453-4057qib7 13642 17 to to IN cord-005453-4057qib7 13642 18 high high JJ cord-005453-4057qib7 13642 19 - - HYPH cord-005453-4057qib7 13642 20 income income NN cord-005453-4057qib7 13642 21 regions region NNS cord-005453-4057qib7 13642 22 . . . cord-005453-4057qib7 13643 1 Our -PRON- PRP$ cord-005453-4057qib7 13643 2 analysis analysis NN cord-005453-4057qib7 13643 3 clearly clearly RB cord-005453-4057qib7 13643 4 indicates indicate VBZ cord-005453-4057qib7 13643 5 normalization normalization NN cord-005453-4057qib7 13643 6 of of IN cord-005453-4057qib7 13643 7 HRQoL HRQoL NNP cord-005453-4057qib7 13643 8 in in IN cord-005453-4057qib7 13643 9 all all DT cord-005453-4057qib7 13643 10 major major JJ cord-005453-4057qib7 13643 11 areas area NNS cord-005453-4057qib7 13643 12 of of IN cord-005453-4057qib7 13643 13 children child NNS cord-005453-4057qib7 13643 14 transplanted transplant VBN cord-005453-4057qib7 13643 15 for for IN cord-005453-4057qib7 13643 16 ST ST NNP cord-005453-4057qib7 13643 17 . . . cord-005453-4057qib7 13644 1 A a DT cord-005453-4057qib7 13644 2 possible possible JJ cord-005453-4057qib7 13644 3 resilience resilience NN cord-005453-4057qib7 13644 4 effect effect NN cord-005453-4057qib7 13644 5 was be VBD cord-005453-4057qib7 13644 6 noted note VBN cord-005453-4057qib7 13644 7 for for IN cord-005453-4057qib7 13644 8 physical physical JJ cord-005453-4057qib7 13644 9 and and CC cord-005453-4057qib7 13644 10 emotional emotional JJ cord-005453-4057qib7 13644 11 scores score NNS cord-005453-4057qib7 13644 12 which which WDT cord-005453-4057qib7 13644 13 were be VBD cord-005453-4057qib7 13644 14 improved improve VBN cord-005453-4057qib7 13644 15 compared compare VBN cord-005453-4057qib7 13644 16 to to IN cord-005453-4057qib7 13644 17 healthy healthy JJ cord-005453-4057qib7 13644 18 sibling sibling NN cord-005453-4057qib7 13644 19 controls control NNS cord-005453-4057qib7 13644 20 . . . cord-005453-4057qib7 13645 1 We -PRON- PRP cord-005453-4057qib7 13645 2 could could MD cord-005453-4057qib7 13645 3 not not RB cord-005453-4057qib7 13645 4 however however RB cord-005453-4057qib7 13645 5 quantify quantify VB cord-005453-4057qib7 13645 6 the the DT cord-005453-4057qib7 13645 7 effect effect NN cord-005453-4057qib7 13645 8 of of IN cord-005453-4057qib7 13645 9 longer long JJR cord-005453-4057qib7 13645 10 - - HYPH cord-005453-4057qib7 13645 11 term term NN cord-005453-4057qib7 13645 12 issues issue NNS cord-005453-4057qib7 13645 13 like like IN cord-005453-4057qib7 13645 14 fertility fertility NN cord-005453-4057qib7 13645 15 impairment impairment NN cord-005453-4057qib7 13645 16 after after IN cord-005453-4057qib7 13645 17 BMT BMT NNP cord-005453-4057qib7 13645 18 which which WDT cord-005453-4057qib7 13645 19 may may MD cord-005453-4057qib7 13645 20 eventually eventually RB cord-005453-4057qib7 13645 21 adversely adversely RB cord-005453-4057qib7 13645 22 impact impact VB cord-005453-4057qib7 13645 23 HRQoL HRQoL NNP cord-005453-4057qib7 13645 24 , , , cord-005453-4057qib7 13645 25 particularly particularly RB cord-005453-4057qib7 13645 26 in in IN cord-005453-4057qib7 13645 27 the the DT cord-005453-4057qib7 13645 28 Indian indian JJ cord-005453-4057qib7 13645 29 culture culture NN cord-005453-4057qib7 13645 30 . . . cord-005453-4057qib7 13646 1 Disclosure disclosure NN cord-005453-4057qib7 13646 2 : : : cord-005453-4057qib7 13647 1 None none NN cord-005453-4057qib7 13647 2 Allogeneic Allogeneic NNP cord-005453-4057qib7 13647 3 hematopoietic hematopoietic JJ cord-005453-4057qib7 13647 4 stem stem NN cord-005453-4057qib7 13647 5 cell cell NN cord-005453-4057qib7 13647 6 transplantation transplantation NN cord-005453-4057qib7 13647 7 in in IN cord-005453-4057qib7 13647 8 ataxia ataxia NN cord-005453-4057qib7 13647 9 telangiectasia telangiectasia NN cord-005453-4057qib7 13647 10 patients patient NNS cord-005453-4057qib7 13647 11 without without IN cord-005453-4057qib7 13647 12 malignancy malignancy NN cord-005453-4057qib7 13647 13 Background background NN cord-005453-4057qib7 13647 14 : : : cord-005453-4057qib7 13648 1 Ataxia Ataxia NNP cord-005453-4057qib7 13648 2 telangiectasia telangiectasia NNP cord-005453-4057qib7 13648 3 ( ( -LRB- cord-005453-4057qib7 13648 4 A A NNP cord-005453-4057qib7 13648 5 - - HYPH cord-005453-4057qib7 13648 6 T T NNP cord-005453-4057qib7 13648 7 ) ) -RRB- cord-005453-4057qib7 13648 8 is be VBZ cord-005453-4057qib7 13648 9 a a DT cord-005453-4057qib7 13648 10 primary primary JJ cord-005453-4057qib7 13648 11 immunodeficiency immunodeficiency NN cord-005453-4057qib7 13648 12 with with IN cord-005453-4057qib7 13648 13 mutations mutation NNS cord-005453-4057qib7 13648 14 in in IN cord-005453-4057qib7 13648 15 ATM atm NN cord-005453-4057qib7 13648 16 - - HYPH cord-005453-4057qib7 13648 17 gene gene NN cord-005453-4057qib7 13648 18 . . . cord-005453-4057qib7 13649 1 Besides besides IN cord-005453-4057qib7 13649 2 a a DT cord-005453-4057qib7 13649 3 slowly slowly RB cord-005453-4057qib7 13649 4 progressive progressive JJ cord-005453-4057qib7 13649 5 neurodegenerative neurodegenerative JJ cord-005453-4057qib7 13649 6 course course NN cord-005453-4057qib7 13649 7 , , , cord-005453-4057qib7 13649 8 A A NNP cord-005453-4057qib7 13649 9 - - HYPH cord-005453-4057qib7 13649 10 T T NNP cord-005453-4057qib7 13649 11 leads lead VBZ cord-005453-4057qib7 13649 12 to to IN cord-005453-4057qib7 13649 13 increased increase VBN cord-005453-4057qib7 13649 14 susceptibility susceptibility NN cord-005453-4057qib7 13649 15 to to IN cord-005453-4057qib7 13649 16 malignancies malignancy NNS cord-005453-4057qib7 13649 17 which which WDT cord-005453-4057qib7 13649 18 affects affect VBZ cord-005453-4057qib7 13649 19 25 25 CD cord-005453-4057qib7 13649 20 % % NN cord-005453-4057qib7 13649 21 of of IN cord-005453-4057qib7 13649 22 patient patient NN cord-005453-4057qib7 13649 23 ( ( -LRB- cord-005453-4057qib7 13649 24 median:12.5 median:12.5 CD cord-005453-4057qib7 13649 25 years year NNS cord-005453-4057qib7 13649 26 ) ) -RRB- cord-005453-4057qib7 13649 27 with with IN cord-005453-4057qib7 13649 28 a a DT cord-005453-4057qib7 13649 29 high high JJ cord-005453-4057qib7 13649 30 mortality mortality NN cord-005453-4057qib7 13649 31 mainly mainly RB cord-005453-4057qib7 13649 32 due due JJ cord-005453-4057qib7 13649 33 tocomplications tocomplication NNS cord-005453-4057qib7 13649 34 of of IN cord-005453-4057qib7 13649 35 conventional conventional JJ cord-005453-4057qib7 13649 36 radio radio NN cord-005453-4057qib7 13649 37 - - HYPH cord-005453-4057qib7 13649 38 chemotherapy chemotherapy NN cord-005453-4057qib7 13649 39 . . . cord-005453-4057qib7 13650 1 The the DT cord-005453-4057qib7 13650 2 incidence incidence NN cord-005453-4057qib7 13650 3 of of IN cord-005453-4057qib7 13650 4 cancer cancer NN cord-005453-4057qib7 13650 5 correlates correlate VBZ cord-005453-4057qib7 13650 6 with with IN cord-005453-4057qib7 13650 7 the the DT cord-005453-4057qib7 13650 8 extent extent NN cord-005453-4057qib7 13650 9 of of IN cord-005453-4057qib7 13650 10 immunodeficiency immunodeficiency NN cord-005453-4057qib7 13650 11 . . . cord-005453-4057qib7 13651 1 Patients patient NNS cord-005453-4057qib7 13651 2 often often RB cord-005453-4057qib7 13651 3 develop develop VBP cord-005453-4057qib7 13651 4 severe severe JJ cord-005453-4057qib7 13651 5 progressive progressive JJ cord-005453-4057qib7 13651 6 granulomatous granulomatous JJ cord-005453-4057qib7 13651 7 skin skin NN cord-005453-4057qib7 13651 8 disease disease NN cord-005453-4057qib7 13651 9 with with IN cord-005453-4057qib7 13651 10 evidence evidence NN cord-005453-4057qib7 13651 11 of of IN cord-005453-4057qib7 13651 12 vaccine vaccine NN cord-005453-4057qib7 13651 13 - - HYPH cord-005453-4057qib7 13651 14 strain strain NN cord-005453-4057qib7 13651 15 rubella rubella NN cord-005453-4057qib7 13651 16 - - HYPH cord-005453-4057qib7 13651 17 virus virus NN cord-005453-4057qib7 13651 18 in in IN cord-005453-4057qib7 13651 19 the the DT cord-005453-4057qib7 13651 20 lesions lesion NNS cord-005453-4057qib7 13651 21 . . . cord-005453-4057qib7 13652 1 Prolonged prolonged JJ cord-005453-4057qib7 13652 2 survival survival NN cord-005453-4057qib7 13652 3 , , , cord-005453-4057qib7 13652 4 neurologic neurologic JJ cord-005453-4057qib7 13652 5 improvement improvement NN cord-005453-4057qib7 13652 6 and and CC cord-005453-4057qib7 13652 7 malignancy malignancy NN cord-005453-4057qib7 13652 8 prevention prevention NN cord-005453-4057qib7 13652 9 was be VBD cord-005453-4057qib7 13652 10 observed observe VBN cord-005453-4057qib7 13652 11 in in IN cord-005453-4057qib7 13652 12 Atm atm NN cord-005453-4057qib7 13652 13 - - HYPH cord-005453-4057qib7 13652 14 deficient deficient JJ cord-005453-4057qib7 13652 15 mice mouse NNS cord-005453-4057qib7 13652 16 after after IN cord-005453-4057qib7 13652 17 treatment treatment NN cord-005453-4057qib7 13652 18 by by IN cord-005453-4057qib7 13652 19 syngeneic syngeneic NNS cord-005453-4057qib7 13652 20 HSCT HSCT NNP cord-005453-4057qib7 13652 21 . . . cord-005453-4057qib7 13653 1 Nevertheless nevertheless RB cord-005453-4057qib7 13653 2 , , , cord-005453-4057qib7 13653 3 pre pre JJ cord-005453-4057qib7 13653 4 - - JJ cord-005453-4057qib7 13653 5 emptive emptive JJ cord-005453-4057qib7 13653 6 HSCT HSCT NNP cord-005453-4057qib7 13653 7 is be VBZ cord-005453-4057qib7 13653 8 not not RB cord-005453-4057qib7 13653 9 routinely routinely RB cord-005453-4057qib7 13653 10 performed perform VBN cord-005453-4057qib7 13653 11 in in IN cord-005453-4057qib7 13653 12 A A NNP cord-005453-4057qib7 13653 13 - - HYPH cord-005453-4057qib7 13653 14 T t NN cord-005453-4057qib7 13653 15 patients patient NNS cord-005453-4057qib7 13653 16 due due JJ cord-005453-4057qib7 13653 17 to to IN cord-005453-4057qib7 13653 18 concerns concern NNS cord-005453-4057qib7 13653 19 about about IN cord-005453-4057qib7 13653 20 neurodegeneration neurodegeneration NN cord-005453-4057qib7 13653 21 and and CC cord-005453-4057qib7 13653 22 toxicity toxicity NN cord-005453-4057qib7 13653 23 . . . cord-005453-4057qib7 13654 1 Methods method NNS cord-005453-4057qib7 13654 2 : : : cord-005453-4057qib7 13654 3 We -PRON- PRP cord-005453-4057qib7 13654 4 present present VBP cord-005453-4057qib7 13654 5 three three CD cord-005453-4057qib7 13654 6 A A NNP cord-005453-4057qib7 13654 7 - - HYPH cord-005453-4057qib7 13654 8 T t NN cord-005453-4057qib7 13654 9 patients patient NNS cord-005453-4057qib7 13654 10 with with IN cord-005453-4057qib7 13654 11 severe severe JJ cord-005453-4057qib7 13654 12 immunodeficiency immunodeficiency NN cord-005453-4057qib7 13654 13 phenotype phenotype NN cord-005453-4057qib7 13654 14 , , , cord-005453-4057qib7 13654 15 undergoing undergo VBG cord-005453-4057qib7 13654 16 successful successful JJ cord-005453-4057qib7 13654 17 HSCT HSCT NNP cord-005453-4057qib7 13654 18 as as IN cord-005453-4057qib7 13654 19 an an DT cord-005453-4057qib7 13654 20 individual individual JJ cord-005453-4057qib7 13654 21 treatment treatment NN cord-005453-4057qib7 13654 22 strategy strategy NN cord-005453-4057qib7 13654 23 intending intend VBG cord-005453-4057qib7 13654 24 to to TO cord-005453-4057qib7 13654 25 restore restore VB cord-005453-4057qib7 13654 26 immunodeficiency immunodeficiency NN cord-005453-4057qib7 13654 27 for for IN cord-005453-4057qib7 13654 28 long long JJ cord-005453-4057qib7 13654 29 - - HYPH cord-005453-4057qib7 13654 30 term term NN cord-005453-4057qib7 13654 31 malignancyprevention malignancyprevention NN cord-005453-4057qib7 13654 32 ( ( -LRB- cord-005453-4057qib7 13654 33 patient-1 patient-1 NNP cord-005453-4057qib7 13654 34 ) ) -RRB- cord-005453-4057qib7 13654 35 and and CC cord-005453-4057qib7 13654 36 to to TO cord-005453-4057qib7 13654 37 treat treat VB cord-005453-4057qib7 13654 38 progressive progressive JJ cord-005453-4057qib7 13654 39 skin skin NN cord-005453-4057qib7 13654 40 / / SYM cord-005453-4057qib7 13654 41 joint joint JJ cord-005453-4057qib7 13654 42 granulomas granuloma NNS cord-005453-4057qib7 13654 43 ( ( -LRB- cord-005453-4057qib7 13655 1 Patients-2 Patients-2 NNP cord-005453-4057qib7 13655 2 and and CC cord-005453-4057qib7 13655 3 -3 -3 NNP cord-005453-4057qib7 13655 4 ) ) -RRB- cord-005453-4057qib7 13655 5 . . . cord-005453-4057qib7 13656 1 Results result NNS cord-005453-4057qib7 13656 2 : : : cord-005453-4057qib7 13657 1 Patient-1 Patient-1 NNP cord-005453-4057qib7 13657 2 underwent undergo VBD cord-005453-4057qib7 13657 3 a a DT cord-005453-4057qib7 13657 4 reduced reduce VBN cord-005453-4057qib7 13657 5 intensity intensity NN cord-005453-4057qib7 13657 6 conditioning conditioning NN cord-005453-4057qib7 13657 7 ( ( -LRB- cord-005453-4057qib7 13657 8 RIC RIC NNP cord-005453-4057qib7 13657 9 ) ) -RRB- cord-005453-4057qib7 13657 10 regimen regimen NN cord-005453-4057qib7 13657 11 at at IN cord-005453-4057qib7 13657 12 4 4 CD cord-005453-4057qib7 13657 13 years year NNS cord-005453-4057qib7 13657 14 of of IN cord-005453-4057qib7 13657 15 age age NN cord-005453-4057qib7 13657 16 including include VBG cord-005453-4057qib7 13657 17 fludarabine fludarabine NN cord-005453-4057qib7 13657 18 ( ( -LRB- cord-005453-4057qib7 13657 19 150 150 CD cord-005453-4057qib7 13657 20 mg mg NNP cord-005453-4057qib7 13657 21 / / SYM cord-005453-4057qib7 13657 22 m m NNP cord-005453-4057qib7 13657 23 2 2 CD cord-005453-4057qib7 13657 24 ) ) -RRB- cord-005453-4057qib7 13657 25 , , , cord-005453-4057qib7 13657 26 cyclophosphamide cyclophosphamide FW cord-005453-4057qib7 13657 27 ( ( -LRB- cord-005453-4057qib7 13657 28 80 80 CD cord-005453-4057qib7 13657 29 mg mg NNP cord-005453-4057qib7 13657 30 / / SYM cord-005453-4057qib7 13657 31 kg kg NNP cord-005453-4057qib7 13657 32 ) ) -RRB- cord-005453-4057qib7 13657 33 , , , cord-005453-4057qib7 13657 34 and and CC cord-005453-4057qib7 13657 35 ATG ATG NNP cord-005453-4057qib7 13657 36 - - HYPH cord-005453-4057qib7 13657 37 Fresenius Fresenius NNP cord-005453-4057qib7 13657 38 ( ( -LRB- cord-005453-4057qib7 13657 39 20 20 CD cord-005453-4057qib7 13657 40 mg mg NNP cord-005453-4057qib7 13657 41 / / SYM cord-005453-4057qib7 13657 42 kg kg NNP cord-005453-4057qib7 13657 43 / / SYM cord-005453-4057qib7 13657 44 d d NN cord-005453-4057qib7 13657 45 ) ) -RRB- cord-005453-4057qib7 13657 46 which which WDT cord-005453-4057qib7 13657 47 was be VBD cord-005453-4057qib7 13657 48 tolerated tolerate VBN cord-005453-4057qib7 13657 49 well well RB cord-005453-4057qib7 13657 50 . . . cord-005453-4057qib7 13658 1 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 13658 2 engraftment engraftment NN cord-005453-4057qib7 13658 3 occurred occur VBD cord-005453-4057qib7 13658 4 by by IN cord-005453-4057qib7 13658 5 day day NN cord-005453-4057qib7 13658 6 +15 +15 NNS cord-005453-4057qib7 13658 7 . . . cord-005453-4057qib7 13659 1 There there EX cord-005453-4057qib7 13659 2 was be VBD cord-005453-4057qib7 13659 3 an an DT cord-005453-4057qib7 13659 4 expansion expansion NN cord-005453-4057qib7 13659 5 of of IN cord-005453-4057qib7 13659 6 naïve naïve JJ cord-005453-4057qib7 13659 7 and and CC cord-005453-4057qib7 13659 8 memory memory NN cord-005453-4057qib7 13659 9 CD4 CD4 NNP cord-005453-4057qib7 13659 10 + + CC cord-005453-4057qib7 13659 11 T T NNP cord-005453-4057qib7 13659 12 - - HYPH cord-005453-4057qib7 13659 13 cells cell NNS cord-005453-4057qib7 13659 14 and and CC cord-005453-4057qib7 13659 15 CD19 CD19 NNP cord-005453-4057qib7 13659 16 + + CC cord-005453-4057qib7 13659 17 cells cell NNS cord-005453-4057qib7 13659 18 . . . cord-005453-4057qib7 13660 1 While while IN cord-005453-4057qib7 13660 2 initially initially RB cord-005453-4057qib7 13660 3 a a DT cord-005453-4057qib7 13660 4 mixed mixed JJ cord-005453-4057qib7 13660 5 donor donor NN cord-005453-4057qib7 13660 6 chimerism chimerism NN cord-005453-4057qib7 13660 7 in in IN cord-005453-4057qib7 13660 8 patient patient NN cord-005453-4057qib7 13660 9 's 's POS cord-005453-4057qib7 13660 10 PBMCs pbmc NNS cord-005453-4057qib7 13660 11 ( ( -LRB- cord-005453-4057qib7 13660 12 10 10 CD cord-005453-4057qib7 13660 13 - - SYM cord-005453-4057qib7 13660 14 20 20 CD cord-005453-4057qib7 13660 15 % % NN cord-005453-4057qib7 13660 16 donor donor NN cord-005453-4057qib7 13660 17 ) ) -RRB- cord-005453-4057qib7 13660 18 was be VBD cord-005453-4057qib7 13660 19 observed observe VBN cord-005453-4057qib7 13660 20 , , , cord-005453-4057qib7 13660 21 patient patient JJ cord-005453-4057qib7 13660 22 's 's POS cord-005453-4057qib7 13660 23 Tcells Tcells NNP cord-005453-4057qib7 13660 24 ( ( -LRB- cord-005453-4057qib7 13660 25 CD3 CD3 NNP cord-005453-4057qib7 13660 26 + + SYM cord-005453-4057qib7 13660 27 ) ) -RRB- cord-005453-4057qib7 13660 28 reached reach VBD cord-005453-4057qib7 13660 29 over over IN cord-005453-4057qib7 13660 30 90 90 CD cord-005453-4057qib7 13660 31 % % NN cord-005453-4057qib7 13660 32 of of IN cord-005453-4057qib7 13660 33 donor donor NN cord-005453-4057qib7 13660 34 origin origin NN cord-005453-4057qib7 13660 35 over over IN cord-005453-4057qib7 13660 36 time time NN cord-005453-4057qib7 13660 37 . . . cord-005453-4057qib7 13661 1 At at IN cord-005453-4057qib7 13661 2 last last JJ cord-005453-4057qib7 13661 3 follow follow NN cord-005453-4057qib7 13661 4 - - HYPH cord-005453-4057qib7 13661 5 up up NN cord-005453-4057qib7 13661 6 ( ( -LRB- cord-005453-4057qib7 13661 7 6 6 CD cord-005453-4057qib7 13661 8 years year NNS cord-005453-4057qib7 13661 9 ) ) -RRB- cord-005453-4057qib7 13661 10 he -PRON- PRP cord-005453-4057qib7 13661 11 is be VBZ cord-005453-4057qib7 13661 12 well well JJ cord-005453-4057qib7 13661 13 , , , cord-005453-4057qib7 13661 14 without without IN cord-005453-4057qib7 13661 15 signs sign NNS cord-005453-4057qib7 13661 16 of of IN cord-005453-4057qib7 13661 17 GVHD GVHD NNP cord-005453-4057qib7 13661 18 and and CC cord-005453-4057qib7 13661 19 organ organ NN cord-005453-4057qib7 13661 20 toxicity toxicity NN cord-005453-4057qib7 13661 21 , , , cord-005453-4057qib7 13661 22 off off IN cord-005453-4057qib7 13661 23 immunosuppression immunosuppression NN cord-005453-4057qib7 13661 24 with with IN cord-005453-4057qib7 13661 25 normal normal JJ cord-005453-4057qib7 13661 26 levels level NNS cord-005453-4057qib7 13661 27 of of IN cord-005453-4057qib7 13661 28 ATM atm NN cord-005453-4057qib7 13661 29 - - HYPH cord-005453-4057qib7 13661 30 protein protein NN cord-005453-4057qib7 13661 31 ; ; : cord-005453-4057qib7 13661 32 his -PRON- PRP$ cord-005453-4057qib7 13661 33 granulomas granuloma NNS cord-005453-4057qib7 13661 34 resolved resolve VBN cord-005453-4057qib7 13661 35 . . . cord-005453-4057qib7 13662 1 Patient-2 Patient-2 NNP cord-005453-4057qib7 13662 2 is be VBZ cord-005453-4057qib7 13662 3 a a DT cord-005453-4057qib7 13662 4 6 6 CD cord-005453-4057qib7 13662 5 year year NN cord-005453-4057qib7 13662 6 - - HYPH cord-005453-4057qib7 13662 7 old old JJ cord-005453-4057qib7 13662 8 male male NN cord-005453-4057qib7 13662 9 who who WP cord-005453-4057qib7 13662 10 was be VBD cord-005453-4057qib7 13662 11 transplanted transplant VBN cord-005453-4057qib7 13662 12 from from IN cord-005453-4057qib7 13662 13 his -PRON- PRP$ cord-005453-4057qib7 13662 14 HLA HLA NNP cord-005453-4057qib7 13662 15 - - HYPH cord-005453-4057qib7 13662 16 identical identical JJ cord-005453-4057qib7 13662 17 sibling sibling NN cord-005453-4057qib7 13662 18 , , , cord-005453-4057qib7 13662 19 conditioned condition VBN cord-005453-4057qib7 13662 20 with with IN cord-005453-4057qib7 13662 21 fludarabine fludarabine NN cord-005453-4057qib7 13662 22 ( ( -LRB- cord-005453-4057qib7 13662 23 150 150 CD cord-005453-4057qib7 13662 24 mg mg NNP cord-005453-4057qib7 13662 25 / / SYM cord-005453-4057qib7 13662 26 m² m² NNP cord-005453-4057qib7 13662 27 ) ) -RRB- cord-005453-4057qib7 13662 28 , , , cord-005453-4057qib7 13662 29 cyclophosphamide cyclophosphamide FW cord-005453-4057qib7 13662 30 ( ( -LRB- cord-005453-4057qib7 13662 31 120 120 CD cord-005453-4057qib7 13662 32 mg mg NNP cord-005453-4057qib7 13662 33 / / SYM cord-005453-4057qib7 13662 34 kg kg NNP cord-005453-4057qib7 13662 35 ) ) -RRB- cord-005453-4057qib7 13662 36 , , , cord-005453-4057qib7 13662 37 and and CC cord-005453-4057qib7 13662 38 ATG ATG NNP cord-005453-4057qib7 13662 39 - - HYPH cord-005453-4057qib7 13662 40 Fresenius Fresenius NNP cord-005453-4057qib7 13662 41 ( ( -LRB- cord-005453-4057qib7 13662 42 20 20 CD cord-005453-4057qib7 13662 43 mg mg NNP cord-005453-4057qib7 13662 44 / / SYM cord-005453-4057qib7 13662 45 kg kg NNP cord-005453-4057qib7 13662 46 ) ) -RRB- cord-005453-4057qib7 13662 47 . . . cord-005453-4057qib7 13663 1 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 13663 2 engraftment engraftment NN cord-005453-4057qib7 13663 3 was be VBD cord-005453-4057qib7 13663 4 observed observe VBN cord-005453-4057qib7 13663 5 by by IN cord-005453-4057qib7 13663 6 day day NN cord-005453-4057qib7 13663 7 +10 +10 CD cord-005453-4057qib7 13663 8 . . . cord-005453-4057qib7 13664 1 T t NN cord-005453-4057qib7 13664 2 - - HYPH cord-005453-4057qib7 13664 3 cell cell NN cord-005453-4057qib7 13664 4 reconstitution reconstitution NN cord-005453-4057qib7 13664 5 started start VBD cord-005453-4057qib7 13664 6 by by IN cord-005453-4057qib7 13664 7 day day NN cord-005453-4057qib7 13664 8 +40 +40 CD cord-005453-4057qib7 13664 9 with with IN cord-005453-4057qib7 13664 10 > > XX cord-005453-4057qib7 13665 1 200μl 200μl NNP cord-005453-4057qib7 13665 2 CD3 CD3 NNP cord-005453-4057qib7 13666 1 + + CC cord-005453-4057qib7 13666 2 T t NN cord-005453-4057qib7 13666 3 - - HYPH cord-005453-4057qib7 13666 4 cells cell NNS cord-005453-4057qib7 13666 5 . . . cord-005453-4057qib7 13667 1 His -PRON- PRP$ cord-005453-4057qib7 13667 2 mixed mixed JJ cord-005453-4057qib7 13667 3 chimerism chimerism NN cord-005453-4057qib7 13667 4 rapidly rapidly RB cord-005453-4057qib7 13667 5 turned turn VBD cord-005453-4057qib7 13667 6 to to IN cord-005453-4057qib7 13667 7 donor donor NN cord-005453-4057qib7 13667 8 origin origin NN cord-005453-4057qib7 13667 9 ( ( -LRB- cord-005453-4057qib7 13667 10 95 95 CD cord-005453-4057qib7 13667 11 % % NN cord-005453-4057qib7 13667 12 donor donor NN cord-005453-4057qib7 13667 13 CD3 cd3 NN cord-005453-4057qib7 13667 14 + + CC cord-005453-4057qib7 13667 15 ) ) -RRB- cord-005453-4057qib7 13667 16 over over IN cord-005453-4057qib7 13667 17 time time NN cord-005453-4057qib7 13667 18 . . . cord-005453-4057qib7 13668 1 There there EX cord-005453-4057qib7 13668 2 was be VBD cord-005453-4057qib7 13668 3 no no DT cord-005453-4057qib7 13668 4 acute acute JJ cord-005453-4057qib7 13668 5 toxicity toxicity NN cord-005453-4057qib7 13668 6 , , , cord-005453-4057qib7 13668 7 however however RB cord-005453-4057qib7 13668 8 , , , cord-005453-4057qib7 13668 9 he -PRON- PRP cord-005453-4057qib7 13668 10 developed develop VBD cord-005453-4057qib7 13668 11 lumbosacral lumbosacral JJ cord-005453-4057qib7 13668 12 pain pain NN cord-005453-4057qib7 13668 13 episodes episode NNS cord-005453-4057qib7 13668 14 with with IN cord-005453-4057qib7 13668 15 evidence evidence NN cord-005453-4057qib7 13668 16 of of IN cord-005453-4057qib7 13668 17 urine urine NN cord-005453-4057qib7 13668 18 BK BK NNP cord-005453-4057qib7 13668 19 - - HYPH cord-005453-4057qib7 13668 20 virus virus NN cord-005453-4057qib7 13668 21 with with IN cord-005453-4057qib7 13668 22 spontaneous spontaneous JJ cord-005453-4057qib7 13668 23 remission remission NN cord-005453-4057qib7 13668 24 . . . cord-005453-4057qib7 13669 1 An an DT cord-005453-4057qib7 13669 2 intermittent intermittent JJ cord-005453-4057qib7 13669 3 metapneumovirus metapneumovirus NN cord-005453-4057qib7 13669 4 associated associate VBD cord-005453-4057qib7 13669 5 pulmonary pulmonary JJ cord-005453-4057qib7 13669 6 hypertension hypertension NN cord-005453-4057qib7 13669 7 was be VBD cord-005453-4057qib7 13669 8 observed observe VBN cord-005453-4057qib7 13669 9 with with IN cord-005453-4057qib7 13669 10 pericardial pericardial JJ cord-005453-4057qib7 13669 11 effusion effusion NN cord-005453-4057qib7 13669 12 . . . cord-005453-4057qib7 13670 1 Treatment treatment NN cord-005453-4057qib7 13670 2 included include VBD cord-005453-4057qib7 13670 3 sildenafil sildenafil NN cord-005453-4057qib7 13670 4 and and CC cord-005453-4057qib7 13670 5 oxygen oxygen NN cord-005453-4057qib7 13670 6 . . . cord-005453-4057qib7 13671 1 At at IN cord-005453-4057qib7 13671 2 last last JJ cord-005453-4057qib7 13671 3 follow follow NN cord-005453-4057qib7 13671 4 - - HYPH cord-005453-4057qib7 13671 5 up up NN cord-005453-4057qib7 13671 6 ( ( -LRB- cord-005453-4057qib7 13671 7 9 9 CD cord-005453-4057qib7 13671 8 months month NNS cord-005453-4057qib7 13671 9 ) ) -RRB- cord-005453-4057qib7 13671 10 patient patient NN cord-005453-4057qib7 13671 11 is be VBZ cord-005453-4057qib7 13671 12 well well RB cord-005453-4057qib7 13671 13 without without IN cord-005453-4057qib7 13671 14 immunosuppression immunosuppression NN cord-005453-4057qib7 13671 15 . . . cord-005453-4057qib7 13672 1 Patient-3 Patient-3 NNP cord-005453-4057qib7 13672 2 suffered suffer VBD cord-005453-4057qib7 13672 3 from from IN cord-005453-4057qib7 13672 4 recurrent recurrent JJ cord-005453-4057qib7 13672 5 chest chest NN cord-005453-4057qib7 13672 6 infections infection NNS cord-005453-4057qib7 13672 7 , , , cord-005453-4057qib7 13672 8 failure failure NN cord-005453-4057qib7 13672 9 to to TO cord-005453-4057qib7 13672 10 thrive thrive VB cord-005453-4057qib7 13672 11 and and CC cord-005453-4057qib7 13672 12 progressive progressive JJ cord-005453-4057qib7 13672 13 and and CC cord-005453-4057qib7 13672 14 debilitating debilitating JJ cord-005453-4057qib7 13672 15 rubella rubella NN cord-005453-4057qib7 13672 16 positive positive JJ cord-005453-4057qib7 13672 17 progressive progressive JJ cord-005453-4057qib7 13672 18 granulomas granuloma NNS cord-005453-4057qib7 13672 19 of of IN cord-005453-4057qib7 13672 20 the the DT cord-005453-4057qib7 13672 21 skin skin NN cord-005453-4057qib7 13672 22 . . . cord-005453-4057qib7 13673 1 She -PRON- PRP cord-005453-4057qib7 13673 2 received receive VBD cord-005453-4057qib7 13673 3 alloHSCT allohsct NN cord-005453-4057qib7 13673 4 from from IN cord-005453-4057qib7 13673 5 an an DT cord-005453-4057qib7 13673 6 HLA HLA NNP cord-005453-4057qib7 13673 7 - - HYPH cord-005453-4057qib7 13673 8 identical identical JJ cord-005453-4057qib7 13673 9 family family NN cord-005453-4057qib7 13673 10 donor donor NN cord-005453-4057qib7 13673 11 at at IN cord-005453-4057qib7 13673 12 6 6 CD cord-005453-4057qib7 13673 13 years year NNS cord-005453-4057qib7 13673 14 of of IN cord-005453-4057qib7 13673 15 age age NN cord-005453-4057qib7 13673 16 . . . cord-005453-4057qib7 13674 1 Conditioning conditioning NN cord-005453-4057qib7 13674 2 included include VBD cord-005453-4057qib7 13674 3 busulfan busulfan NN cord-005453-4057qib7 13674 4 ( ( -LRB- cord-005453-4057qib7 13674 5 2.2 2.2 CD cord-005453-4057qib7 13674 6 mg mg NNP cord-005453-4057qib7 13674 7 / / SYM cord-005453-4057qib7 13674 8 kg kg NNP cord-005453-4057qib7 13674 9 ) ) -RRB- cord-005453-4057qib7 13674 10 , , , cord-005453-4057qib7 13674 11 fludarabine fludarabine NNP cord-005453-4057qib7 13674 12 ( ( -LRB- cord-005453-4057qib7 13674 13 150 150 CD cord-005453-4057qib7 13674 14 mg mg NNP cord-005453-4057qib7 13674 15 / / SYM cord-005453-4057qib7 13674 16 m² m² NNP cord-005453-4057qib7 13674 17 ) ) -RRB- cord-005453-4057qib7 13674 18 , , , cord-005453-4057qib7 13674 19 cyclophosphamide cyclophosphamide FW cord-005453-4057qib7 13674 20 ( ( -LRB- cord-005453-4057qib7 13674 21 40 40 CD cord-005453-4057qib7 13674 22 mg mg NNP cord-005453-4057qib7 13674 23 / / SYM cord-005453-4057qib7 13674 24 kg kg NNP cord-005453-4057qib7 13674 25 ) ) -RRB- cord-005453-4057qib7 13674 26 , , , cord-005453-4057qib7 13674 27 and and CC cord-005453-4057qib7 13674 28 alemtuzumab alemtuzumab NNP cord-005453-4057qib7 13674 29 ( ( -LRB- cord-005453-4057qib7 13674 30 1 1 CD cord-005453-4057qib7 13674 31 x x SYM cord-005453-4057qib7 13674 32 5mg 5mg NNP cord-005453-4057qib7 13674 33 / / SYM cord-005453-4057qib7 13674 34 m² m² NNP cord-005453-4057qib7 13674 35 , , , cord-005453-4057qib7 13674 36 3 3 CD cord-005453-4057qib7 13674 37 x x SYM cord-005453-4057qib7 13674 38 10mg 10mg NN cord-005453-4057qib7 13674 39 / / SYM cord-005453-4057qib7 13674 40 m² m² NNP cord-005453-4057qib7 13674 41 ) ) -RRB- cord-005453-4057qib7 13674 42 . . . cord-005453-4057qib7 13675 1 HSCT HSCT NNP cord-005453-4057qib7 13675 2 was be VBD cord-005453-4057qib7 13675 3 complicated complicate VBN cord-005453-4057qib7 13675 4 by by IN cord-005453-4057qib7 13675 5 intermittent intermittent JJ cord-005453-4057qib7 13675 6 acute acute JJ cord-005453-4057qib7 13675 7 renal renal JJ cord-005453-4057qib7 13675 8 failure failure NN cord-005453-4057qib7 13675 9 , , , cord-005453-4057qib7 13675 10 CMV CMV NNP cord-005453-4057qib7 13675 11 reactivation reactivation NN cord-005453-4057qib7 13675 12 and and CC cord-005453-4057qib7 13675 13 TMA TMA NNP cord-005453-4057qib7 13675 14 . . . cord-005453-4057qib7 13676 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 13676 2 recovery recovery NN cord-005453-4057qib7 13676 3 was be VBD cord-005453-4057qib7 13676 4 observed observe VBN cord-005453-4057qib7 13676 5 by by IN cord-005453-4057qib7 13676 6 day day NN cord-005453-4057qib7 13676 7 +22 +22 NNS cord-005453-4057qib7 13676 8 . . . cord-005453-4057qib7 13677 1 T t NN cord-005453-4057qib7 13677 2 - - HYPH cord-005453-4057qib7 13677 3 cell cell NN cord-005453-4057qib7 13677 4 chimerism chimerism NN cord-005453-4057qib7 13677 5 increased increase VBD cord-005453-4057qib7 13677 6 rapidly rapidly RB cord-005453-4057qib7 13677 7 over over IN cord-005453-4057qib7 13677 8 time time NN cord-005453-4057qib7 13677 9 ( ( -LRB- cord-005453-4057qib7 13677 10 > > NFP cord-005453-4057qib7 13677 11 90 90 CD cord-005453-4057qib7 13677 12 % % NN cord-005453-4057qib7 13677 13 donor donor NN cord-005453-4057qib7 13677 14 ) ) -RRB- cord-005453-4057qib7 13677 15 . . . cord-005453-4057qib7 13678 1 At at IN cord-005453-4057qib7 13678 2 last last JJ cord-005453-4057qib7 13678 3 follow follow NN cord-005453-4057qib7 13678 4 - - HYPH cord-005453-4057qib7 13678 5 up up NN cord-005453-4057qib7 13678 6 ( ( -LRB- cord-005453-4057qib7 13678 7 7 7 CD cord-005453-4057qib7 13678 8 months month NNS cord-005453-4057qib7 13678 9 ) ) -RRB- cord-005453-4057qib7 13678 10 patient patient NN cord-005453-4057qib7 13678 11 is be VBZ cord-005453-4057qib7 13678 12 well well JJ cord-005453-4057qib7 13678 13 , , , cord-005453-4057qib7 13678 14 off off IN cord-005453-4057qib7 13678 15 immunosuppression immunosuppression NN cord-005453-4057qib7 13678 16 and and CC cord-005453-4057qib7 13678 17 IVIG IVIG NNP cord-005453-4057qib7 13678 18 . . . cord-005453-4057qib7 13679 1 Her -PRON- PRP$ cord-005453-4057qib7 13679 2 skin skin NN cord-005453-4057qib7 13679 3 granuloma granuloma NN cord-005453-4057qib7 13679 4 resolved resolve VBN cord-005453-4057qib7 13679 5 with with IN cord-005453-4057qib7 13679 6 scarring scar VBG cord-005453-4057qib7 13679 7 residues residue NNS cord-005453-4057qib7 13679 8 . . . cord-005453-4057qib7 13680 1 Conclusions conclusion NNS cord-005453-4057qib7 13680 2 : : : cord-005453-4057qib7 13681 1 Pre pre JJ cord-005453-4057qib7 13681 2 - - JJ cord-005453-4057qib7 13681 3 emptive emptive JJ cord-005453-4057qib7 13681 4 alloHSCT allohsct NN cord-005453-4057qib7 13681 5 is be VBZ cord-005453-4057qib7 13681 6 feasible feasible JJ cord-005453-4057qib7 13681 7 in in IN cord-005453-4057qib7 13681 8 A A NNP cord-005453-4057qib7 13681 9 - - HYPH cord-005453-4057qib7 13681 10 T t NN cord-005453-4057qib7 13681 11 when when WRB cord-005453-4057qib7 13681 12 reduced reduce VBN cord-005453-4057qib7 13681 13 intensity intensity NN cord-005453-4057qib7 13681 14 conditioning conditioning NN cord-005453-4057qib7 13681 15 is be VBZ cord-005453-4057qib7 13681 16 used use VBN cord-005453-4057qib7 13681 17 and and CC cord-005453-4057qib7 13681 18 can can MD cord-005453-4057qib7 13681 19 correct correct VB cord-005453-4057qib7 13681 20 the the DT cord-005453-4057qib7 13681 21 immunodeficiency immunodeficiency NN cord-005453-4057qib7 13681 22 . . . cord-005453-4057qib7 13682 1 It -PRON- PRP cord-005453-4057qib7 13682 2 might may MD cord-005453-4057qib7 13682 3 be be VB cord-005453-4057qib7 13682 4 a a DT cord-005453-4057qib7 13682 5 treatment treatment NN cord-005453-4057qib7 13682 6 option option NN cord-005453-4057qib7 13682 7 for for IN cord-005453-4057qib7 13682 8 some some DT cord-005453-4057qib7 13682 9 A A NNP cord-005453-4057qib7 13682 10 - - HYPH cord-005453-4057qib7 13682 11 T t NN cord-005453-4057qib7 13682 12 patients patient NNS cord-005453-4057qib7 13682 13 at at IN cord-005453-4057qib7 13682 14 high high JJ cord-005453-4057qib7 13682 15 risk risk NN cord-005453-4057qib7 13682 16 of of IN cord-005453-4057qib7 13682 17 hematological hematological JJ cord-005453-4057qib7 13682 18 malignancy malignancy NN cord-005453-4057qib7 13682 19 and and CC cord-005453-4057qib7 13682 20 severe severe JJ cord-005453-4057qib7 13682 21 granulomatous granulomatous JJ cord-005453-4057qib7 13682 22 skin skin NN cord-005453-4057qib7 13682 23 disease disease NN cord-005453-4057qib7 13682 24 . . . cord-005453-4057qib7 13683 1 To to TO cord-005453-4057qib7 13683 2 what what WDT cord-005453-4057qib7 13683 3 extent extent NN cord-005453-4057qib7 13683 4 the the DT cord-005453-4057qib7 13683 5 restored restore VBN cord-005453-4057qib7 13683 6 immune immune JJ cord-005453-4057qib7 13683 7 system system NN cord-005453-4057qib7 13683 8 and and CC cord-005453-4057qib7 13683 9 the the DT cord-005453-4057qib7 13683 10 increase increase NN cord-005453-4057qib7 13683 11 of of IN cord-005453-4057qib7 13683 12 ATM atm NN cord-005453-4057qib7 13683 13 - - HYPH cord-005453-4057qib7 13683 14 protein protein NN cord-005453-4057qib7 13683 15 in in IN cord-005453-4057qib7 13683 16 these these DT cord-005453-4057qib7 13683 17 patients patient NNS cord-005453-4057qib7 13683 18 could could MD cord-005453-4057qib7 13683 19 prevent prevent VB cord-005453-4057qib7 13683 20 the the DT cord-005453-4057qib7 13683 21 development development NN cord-005453-4057qib7 13683 22 of of IN cord-005453-4057qib7 13683 23 other other JJ cord-005453-4057qib7 13683 24 malignancies malignancy NNS cord-005453-4057qib7 13683 25 needs need VBZ cord-005453-4057qib7 13683 26 to to TO cord-005453-4057qib7 13683 27 be be VB cord-005453-4057qib7 13683 28 evaluated evaluate VBN cord-005453-4057qib7 13683 29 further further RB cord-005453-4057qib7 13683 30 . . . cord-005453-4057qib7 13684 1 Disclosure disclosure NN cord-005453-4057qib7 13684 2 : : : cord-005453-4057qib7 13684 3 Nothing nothing NN cord-005453-4057qib7 13684 4 to to TO cord-005453-4057qib7 13684 5 disclose disclose VB cord-005453-4057qib7 13684 6 P625 P625 NNP cord-005453-4057qib7 13684 7 Abstract Abstract NNP cord-005453-4057qib7 13684 8 withdrawn withdraw VBN cord-005453-4057qib7 13684 9 . . . cord-005453-4057qib7 13685 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 13685 2 stem stem NN cord-005453-4057qib7 13685 3 cell cell NN cord-005453-4057qib7 13685 4 transplantation transplantation NN cord-005453-4057qib7 13685 5 in in IN cord-005453-4057qib7 13685 6 diamond diamond NN cord-005453-4057qib7 13685 7 blackfan blackfan NN cord-005453-4057qib7 13685 8 anemia anemia NN cord-005453-4057qib7 13685 9 : : : cord-005453-4057qib7 13686 1 Brazilian brazilian JJ cord-005453-4057qib7 13686 2 experience experience NN cord-005453-4057qib7 13686 3 Background background NN cord-005453-4057qib7 13686 4 : : : cord-005453-4057qib7 13687 1 Diamond Diamond NNP cord-005453-4057qib7 13687 2 - - HYPH cord-005453-4057qib7 13687 3 Blackfan Blackfan NNP cord-005453-4057qib7 13687 4 anemia anemia NN cord-005453-4057qib7 13687 5 ( ( -LRB- cord-005453-4057qib7 13687 6 DBA DBA NNP cord-005453-4057qib7 13687 7 ) ) -RRB- cord-005453-4057qib7 13687 8 is be VBZ cord-005453-4057qib7 13687 9 a a DT cord-005453-4057qib7 13687 10 rare rare JJ cord-005453-4057qib7 13687 11 inherited inherit VBN cord-005453-4057qib7 13687 12 red red JJ cord-005453-4057qib7 13687 13 cell cell NN cord-005453-4057qib7 13687 14 aplasia aplasia NNP cord-005453-4057qib7 13687 15 caused cause VBN cord-005453-4057qib7 13687 16 by by IN cord-005453-4057qib7 13687 17 an an DT cord-005453-4057qib7 13687 18 intrinsic intrinsic JJ cord-005453-4057qib7 13687 19 defect defect NN cord-005453-4057qib7 13687 20 of of IN cord-005453-4057qib7 13687 21 erythropoietic erythropoietic JJ cord-005453-4057qib7 13687 22 progenitors progenitor NNS cord-005453-4057qib7 13687 23 . . . cord-005453-4057qib7 13688 1 The the DT cord-005453-4057qib7 13688 2 main main JJ cord-005453-4057qib7 13688 3 therapeutic therapeutic JJ cord-005453-4057qib7 13688 4 approach approach NN cord-005453-4057qib7 13688 5 is be VBZ cord-005453-4057qib7 13688 6 based base VBN cord-005453-4057qib7 13688 7 on on IN cord-005453-4057qib7 13688 8 repeated repeat VBN cord-005453-4057qib7 13688 9 red red JJ cord-005453-4057qib7 13688 10 blood blood NN cord-005453-4057qib7 13688 11 cell cell NN cord-005453-4057qib7 13688 12 transfusions transfusion NNS cord-005453-4057qib7 13688 13 and/or and/or CC cord-005453-4057qib7 13688 14 corticosteroid corticosteroid NN cord-005453-4057qib7 13688 15 therapy therapy NN cord-005453-4057qib7 13688 16 . . . cord-005453-4057qib7 13689 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 13689 2 stem stem NN cord-005453-4057qib7 13689 3 cell cell NN cord-005453-4057qib7 13689 4 transplantation transplantation NN cord-005453-4057qib7 13689 5 ( ( -LRB- cord-005453-4057qib7 13689 6 HSCT HSCT NNP cord-005453-4057qib7 13689 7 ) ) -RRB- cord-005453-4057qib7 13689 8 , , , cord-005453-4057qib7 13689 9 a a DT cord-005453-4057qib7 13689 10 potentially potentially RB cord-005453-4057qib7 13689 11 curative curative JJ cord-005453-4057qib7 13689 12 treatment treatment NN cord-005453-4057qib7 13689 13 for for IN cord-005453-4057qib7 13689 14 DBA DBA NNP cord-005453-4057qib7 13689 15 , , , cord-005453-4057qib7 13689 16 is be VBZ cord-005453-4057qib7 13689 17 indicated indicate VBN cord-005453-4057qib7 13689 18 for for IN cord-005453-4057qib7 13689 19 patients patient NNS cord-005453-4057qib7 13689 20 that that WDT cord-005453-4057qib7 13689 21 do do VBP cord-005453-4057qib7 13689 22 not not RB cord-005453-4057qib7 13689 23 respond respond VB cord-005453-4057qib7 13689 24 to to IN cord-005453-4057qib7 13689 25 first first JJ cord-005453-4057qib7 13689 26 - - HYPH cord-005453-4057qib7 13689 27 line line NN cord-005453-4057qib7 13689 28 therapy therapy NN cord-005453-4057qib7 13689 29 . . . cord-005453-4057qib7 13690 1 Methods method NNS cord-005453-4057qib7 13690 2 : : : cord-005453-4057qib7 13691 1 The the DT cord-005453-4057qib7 13691 2 aim aim NN cord-005453-4057qib7 13691 3 of of IN cord-005453-4057qib7 13691 4 our -PRON- PRP$ cord-005453-4057qib7 13691 5 retrospective retrospective JJ cord-005453-4057qib7 13691 6 study study NN cord-005453-4057qib7 13691 7 is be VBZ cord-005453-4057qib7 13691 8 to to TO cord-005453-4057qib7 13691 9 report report VB cord-005453-4057qib7 13691 10 the the DT cord-005453-4057qib7 13691 11 outcomes outcome NNS cord-005453-4057qib7 13691 12 of of IN cord-005453-4057qib7 13691 13 30 30 CD cord-005453-4057qib7 13691 14 Brazilian brazilian JJ cord-005453-4057qib7 13691 15 DBA DBA NNP cord-005453-4057qib7 13691 16 patients patient NNS cord-005453-4057qib7 13691 17 transplanted transplant VBN cord-005453-4057qib7 13691 18 between between IN cord-005453-4057qib7 13691 19 1990 1990 CD cord-005453-4057qib7 13691 20 and and CC cord-005453-4057qib7 13691 21 2017 2017 CD cord-005453-4057qib7 13691 22 in in IN cord-005453-4057qib7 13691 23 9 9 CD cord-005453-4057qib7 13691 24 BMT BMT NNP cord-005453-4057qib7 13691 25 centers center NNS cord-005453-4057qib7 13691 26 . . . cord-005453-4057qib7 13692 1 The the DT cord-005453-4057qib7 13692 2 median median JJ cord-005453-4057qib7 13692 3 age age NN cord-005453-4057qib7 13692 4 of of IN cord-005453-4057qib7 13692 5 the the DT cord-005453-4057qib7 13692 6 patients patient NNS cord-005453-4057qib7 13692 7 was be VBD cord-005453-4057qib7 13692 8 5 5 CD cord-005453-4057qib7 13692 9 ys ys NNP cord-005453-4057qib7 13692 10 ( ( -LRB- cord-005453-4057qib7 13692 11 range range NNP cord-005453-4057qib7 13692 12 1 1 CD cord-005453-4057qib7 13692 13 - - SYM cord-005453-4057qib7 13692 14 15 15 CD cord-005453-4057qib7 13692 15 ) ) -RRB- cord-005453-4057qib7 13692 16 and and CC cord-005453-4057qib7 13692 17 60 60 CD cord-005453-4057qib7 13692 18 % % NN cord-005453-4057qib7 13692 19 were be VBD cord-005453-4057qib7 13692 20 male male JJ cord-005453-4057qib7 13692 21 . . . cord-005453-4057qib7 13693 1 Seventeen seventeen CD cord-005453-4057qib7 13693 2 patients patient NNS cord-005453-4057qib7 13693 3 ( ( -LRB- cord-005453-4057qib7 13693 4 57 57 CD cord-005453-4057qib7 13693 5 % % NN cord-005453-4057qib7 13693 6 ) ) -RRB- cord-005453-4057qib7 13693 7 were be VBD cord-005453-4057qib7 13693 8 transplanted transplant VBN cord-005453-4057qib7 13693 9 with with IN cord-005453-4057qib7 13693 10 matched match VBN cord-005453-4057qib7 13693 11 related related JJ cord-005453-4057qib7 13693 12 donors donor NNS cord-005453-4057qib7 13693 13 ( ( -LRB- cord-005453-4057qib7 13693 14 MRD MRD NNP cord-005453-4057qib7 13693 15 ) ) -RRB- cord-005453-4057qib7 13693 16 and and CC cord-005453-4057qib7 13693 17 thirteen thirteen CD cord-005453-4057qib7 13693 18 ( ( -LRB- cord-005453-4057qib7 13693 19 43 43 CD cord-005453-4057qib7 13693 20 % % NN cord-005453-4057qib7 13693 21 ) ) -RRB- cord-005453-4057qib7 13693 22 from from IN cord-005453-4057qib7 13693 23 matched match VBN cord-005453-4057qib7 13693 24 and and CC cord-005453-4057qib7 13693 25 mismatched mismatched JJ cord-005453-4057qib7 13693 26 unrelated unrelated JJ cord-005453-4057qib7 13693 27 donors donor NNS cord-005453-4057qib7 13693 28 ( ( -LRB- cord-005453-4057qib7 13693 29 MUD mud NN cord-005453-4057qib7 13693 30 / / SYM cord-005453-4057qib7 13693 31 MMUD MMUD NNP cord-005453-4057qib7 13693 32 ) ) -RRB- cord-005453-4057qib7 13693 33 . . . cord-005453-4057qib7 13694 1 In in IN cord-005453-4057qib7 13694 2 the the DT cord-005453-4057qib7 13694 3 MRD MRD NNP cord-005453-4057qib7 13694 4 group group NN cord-005453-4057qib7 13694 5 all all DT cord-005453-4057qib7 13694 6 patients patient NNS cord-005453-4057qib7 13694 7 received receive VBD cord-005453-4057qib7 13694 8 bone bone NN cord-005453-4057qib7 13694 9 marrow marrow NN cord-005453-4057qib7 13694 10 as as IN cord-005453-4057qib7 13694 11 HSC HSC NNP cord-005453-4057qib7 13694 12 source source NN cord-005453-4057qib7 13694 13 , , , cord-005453-4057qib7 13694 14 while while IN cord-005453-4057qib7 13694 15 in in IN cord-005453-4057qib7 13694 16 the the DT cord-005453-4057qib7 13694 17 MUD MUD NNP cord-005453-4057qib7 13694 18 / / SYM cord-005453-4057qib7 13694 19 MMUD MMUD NNP cord-005453-4057qib7 13694 20 , , , cord-005453-4057qib7 13694 21 eight eight CD cord-005453-4057qib7 13694 22 patients patient NNS cord-005453-4057qib7 13694 23 received receive VBD cord-005453-4057qib7 13694 24 bone bone NN cord-005453-4057qib7 13694 25 marrow marrow NN cord-005453-4057qib7 13694 26 and and CC cord-005453-4057qib7 13694 27 five five CD cord-005453-4057qib7 13694 28 received receive VBD cord-005453-4057qib7 13694 29 cord cord NN cord-005453-4057qib7 13694 30 blood blood NN cord-005453-4057qib7 13694 31 . . . cord-005453-4057qib7 13695 1 All all DT cord-005453-4057qib7 13695 2 patients patient NNS cord-005453-4057qib7 13695 3 with with IN cord-005453-4057qib7 13695 4 incompatibilities incompatibility NNS cord-005453-4057qib7 13695 5 ( ( -LRB- cord-005453-4057qib7 13695 6 mismatched mismatched JJ cord-005453-4057qib7 13695 7 ) ) -RRB- cord-005453-4057qib7 13695 8 were be VBD cord-005453-4057qib7 13695 9 UCB UCB NNP cord-005453-4057qib7 13695 10 ( ( -LRB- cord-005453-4057qib7 13695 11 5/5 5/5 CD cord-005453-4057qib7 13695 12 ) ) -RRB- cord-005453-4057qib7 13695 13 . . . cord-005453-4057qib7 13696 1 Nineteen nineteen CD cord-005453-4057qib7 13696 2 recipients recipient NNS cord-005453-4057qib7 13696 3 were be VBD cord-005453-4057qib7 13696 4 conditioned condition VBN cord-005453-4057qib7 13696 5 with with IN cord-005453-4057qib7 13696 6 busulfan busulfan NN cord-005453-4057qib7 13696 7 plus plus CC cord-005453-4057qib7 13696 8 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 13696 9 , , , cord-005453-4057qib7 13696 10 while while IN cord-005453-4057qib7 13696 11 the the DT cord-005453-4057qib7 13696 12 remaining remain VBG cord-005453-4057qib7 13696 13 11 11 CD cord-005453-4057qib7 13696 14 received receive VBN cord-005453-4057qib7 13696 15 fludarabine fludarabine NN cord-005453-4057qib7 13696 16 and and CC cord-005453-4057qib7 13696 17 busulfan busulfan NN cord-005453-4057qib7 13696 18 , , , cord-005453-4057qib7 13696 19 which which WDT cord-005453-4057qib7 13696 20 has have VBZ cord-005453-4057qib7 13696 21 been be VBN cord-005453-4057qib7 13696 22 the the DT cord-005453-4057qib7 13696 23 preferred preferred JJ cord-005453-4057qib7 13696 24 regimen regimen NN cord-005453-4057qib7 13696 25 in in IN cord-005453-4057qib7 13696 26 Brazil Brazil NNP cord-005453-4057qib7 13696 27 in in IN cord-005453-4057qib7 13696 28 the the DT cord-005453-4057qib7 13696 29 recent recent JJ cord-005453-4057qib7 13696 30 years year NNS cord-005453-4057qib7 13696 31 . . . cord-005453-4057qib7 13697 1 After after IN cord-005453-4057qib7 13697 2 transplant transplant NN cord-005453-4057qib7 13697 3 , , , cord-005453-4057qib7 13697 4 most most JJS cord-005453-4057qib7 13697 5 ( ( -LRB- cord-005453-4057qib7 13697 6 n=24 n=24 NNP cord-005453-4057qib7 13697 7 ) ) -RRB- cord-005453-4057qib7 13697 8 of of IN cord-005453-4057qib7 13697 9 the the DT cord-005453-4057qib7 13697 10 MRD MRD NNP cord-005453-4057qib7 13697 11 and and CC cord-005453-4057qib7 13697 12 MUD MUD NNP cord-005453-4057qib7 13697 13 recipients recipient NNS cord-005453-4057qib7 13697 14 received receive VBD cord-005453-4057qib7 13697 15 cyclosporine cyclosporine NN cord-005453-4057qib7 13697 16 and and CC cord-005453-4057qib7 13697 17 short short JJ cord-005453-4057qib7 13697 18 course course NN cord-005453-4057qib7 13697 19 methotrexate methotrexate NNP cord-005453-4057qib7 13697 20 as as IN cord-005453-4057qib7 13697 21 graft graft NN cord-005453-4057qib7 13697 22 versus versus IN cord-005453-4057qib7 13697 23 host host NN cord-005453-4057qib7 13697 24 disease disease NN cord-005453-4057qib7 13697 25 ( ( -LRB- cord-005453-4057qib7 13697 26 GvHD GvHD NNP cord-005453-4057qib7 13697 27 ) ) -RRB- cord-005453-4057qib7 13697 28 prophylaxis prophylaxis NN cord-005453-4057qib7 13697 29 . . . cord-005453-4057qib7 13698 1 Results result NNS cord-005453-4057qib7 13698 2 : : : cord-005453-4057qib7 13699 1 Twenty twenty CD cord-005453-4057qib7 13699 2 - - HYPH cord-005453-4057qib7 13699 3 two two CD cord-005453-4057qib7 13699 4 out out IN cord-005453-4057qib7 13699 5 of of IN cord-005453-4057qib7 13699 6 the the DT cord-005453-4057qib7 13699 7 30 30 CD cord-005453-4057qib7 13699 8 patients patient NNS cord-005453-4057qib7 13699 9 were be VBD cord-005453-4057qib7 13699 10 alive alive JJ cord-005453-4057qib7 13699 11 and and CC cord-005453-4057qib7 13699 12 disease disease NN cord-005453-4057qib7 13699 13 - - HYPH cord-005453-4057qib7 13699 14 free free JJ cord-005453-4057qib7 13699 15 at at IN cord-005453-4057qib7 13699 16 a a DT cord-005453-4057qib7 13699 17 median median JJ cord-005453-4057qib7 13699 18 follow follow NN cord-005453-4057qib7 13699 19 - - HYPH cord-005453-4057qib7 13699 20 up up NN cord-005453-4057qib7 13699 21 of of IN cord-005453-4057qib7 13699 22 24 24 CD cord-005453-4057qib7 13699 23 months month NNS cord-005453-4057qib7 13699 24 ( ( -LRB- cord-005453-4057qib7 13699 25 range range VBP cord-005453-4057qib7 13699 26 1 1 CD cord-005453-4057qib7 13699 27 to to IN cord-005453-4057qib7 13699 28 213 213 CD cord-005453-4057qib7 13699 29 months month NNS cord-005453-4057qib7 13699 30 ) ) -RRB- cord-005453-4057qib7 13699 31 . . . cord-005453-4057qib7 13700 1 The the DT cord-005453-4057qib7 13700 2 3-year 3-year CD cord-005453-4057qib7 13700 3 overall overall JJ cord-005453-4057qib7 13700 4 survival survival NN cord-005453-4057qib7 13700 5 ( ( -LRB- cord-005453-4057qib7 13700 6 OS OS NNP cord-005453-4057qib7 13700 7 ) ) -RRB- cord-005453-4057qib7 13700 8 was be VBD cord-005453-4057qib7 13700 9 71 71 CD cord-005453-4057qib7 13700 10 % % NN cord-005453-4057qib7 13701 1 ( ( -LRB- cord-005453-4057qib7 13701 2 CI CI NNP cord-005453-4057qib7 13701 3 51 51 CD cord-005453-4057qib7 13701 4 - - SYM cord-005453-4057qib7 13701 5 91 91 CD cord-005453-4057qib7 13701 6 % % NN cord-005453-4057qib7 13701 7 ) ) -RRB- cord-005453-4057qib7 13702 1 ( ( -LRB- cord-005453-4057qib7 13702 2 Fig Fig NNP cord-005453-4057qib7 13702 3 1 1 CD cord-005453-4057qib7 13702 4 ) ) -RRB- cord-005453-4057qib7 13702 5 . . . cord-005453-4057qib7 13703 1 Similar similar JJ cord-005453-4057qib7 13703 2 results result NNS cord-005453-4057qib7 13703 3 have have VBP cord-005453-4057qib7 13703 4 been be VBN cord-005453-4057qib7 13703 5 demonstrated demonstrate VBN cord-005453-4057qib7 13703 6 in in IN cord-005453-4057qib7 13703 7 studies study NNS cord-005453-4057qib7 13703 8 from from IN cord-005453-4057qib7 13703 9 Europe Europe NNP cord-005453-4057qib7 13703 10 and and CC cord-005453-4057qib7 13703 11 from from IN cord-005453-4057qib7 13703 12 the the DT cord-005453-4057qib7 13703 13 United United NNP cord-005453-4057qib7 13703 14 States States NNP cord-005453-4057qib7 13703 15 . . . cord-005453-4057qib7 13704 1 When when WRB cord-005453-4057qib7 13704 2 analyzed analyze VBN cord-005453-4057qib7 13704 3 according accord VBG cord-005453-4057qib7 13704 4 to to IN cord-005453-4057qib7 13704 5 donor donor NN cord-005453-4057qib7 13704 6 type type NN cord-005453-4057qib7 13704 7 , , , cord-005453-4057qib7 13704 8 OS OS NNP cord-005453-4057qib7 13704 9 was be VBD cord-005453-4057qib7 13704 10 73 73 CD cord-005453-4057qib7 13704 11 % % NN cord-005453-4057qib7 13705 1 ( ( -LRB- cord-005453-4057qib7 13705 2 CI CI NNP cord-005453-4057qib7 13705 3 55 55 CD cord-005453-4057qib7 13705 4 - - SYM cord-005453-4057qib7 13705 5 100 100 CD cord-005453-4057qib7 13705 6 % % NN cord-005453-4057qib7 13705 7 ) ) -RRB- cord-005453-4057qib7 13705 8 and and CC cord-005453-4057qib7 13705 9 66 66 CD cord-005453-4057qib7 13705 10 % % NN cord-005453-4057qib7 13706 1 ( ( -LRB- cord-005453-4057qib7 13706 2 CI CI NNP cord-005453-4057qib7 13706 3 43 43 CD cord-005453-4057qib7 13706 4 - - SYM cord-005453-4057qib7 13706 5 100 100 CD cord-005453-4057qib7 13706 6 % % NN cord-005453-4057qib7 13706 7 ) ) -RRB- cord-005453-4057qib7 13706 8 in in IN cord-005453-4057qib7 13706 9 MRD MRD NNP cord-005453-4057qib7 13706 10 and and CC cord-005453-4057qib7 13706 11 MUD MUD NNP cord-005453-4057qib7 13706 12 / / SYM cord-005453-4057qib7 13706 13 MMUD MMUD NNP cord-005453-4057qib7 13706 14 respectively respectively RB cord-005453-4057qib7 13706 15 ( ( -LRB- cord-005453-4057qib7 13706 16 fig fig NN cord-005453-4057qib7 13706 17 2 2 CD cord-005453-4057qib7 13706 18 ) ) -RRB- cord-005453-4057qib7 13706 19 . . . cord-005453-4057qib7 13707 1 Three three CD cord-005453-4057qib7 13707 2 out out IN cord-005453-4057qib7 13707 3 of of IN cord-005453-4057qib7 13707 4 the the DT cord-005453-4057qib7 13707 5 5 5 CD cord-005453-4057qib7 13707 6 patients patient NNS cord-005453-4057qib7 13707 7 who who WP cord-005453-4057qib7 13707 8 were be VBD cord-005453-4057qib7 13707 9 transplanted transplant VBN cord-005453-4057qib7 13707 10 with with IN cord-005453-4057qib7 13707 11 UCB UCB NNP cord-005453-4057qib7 13707 12 died die VBD cord-005453-4057qib7 13707 13 . . . cord-005453-4057qib7 13708 1 These these DT cord-005453-4057qib7 13708 2 results result NNS cord-005453-4057qib7 13708 3 are be VBP cord-005453-4057qib7 13708 4 in in IN cord-005453-4057qib7 13708 5 agreement agreement NN cord-005453-4057qib7 13708 6 with with IN cord-005453-4057qib7 13708 7 those those DT cord-005453-4057qib7 13708 8 of of IN cord-005453-4057qib7 13708 9 previously previously RB cord-005453-4057qib7 13708 10 published publish VBN cord-005453-4057qib7 13708 11 data datum NNS cord-005453-4057qib7 13708 12 showing show VBG cord-005453-4057qib7 13708 13 worse bad JJR cord-005453-4057qib7 13708 14 results result NNS cord-005453-4057qib7 13708 15 in in IN cord-005453-4057qib7 13708 16 unrelated unrelated JJ cord-005453-4057qib7 13708 17 UCB UCB NNP cord-005453-4057qib7 13708 18 transplants transplant NNS cord-005453-4057qib7 13708 19 . . . cord-005453-4057qib7 13709 1 Twenty twenty CD cord-005453-4057qib7 13709 2 - - HYPH cord-005453-4057qib7 13709 3 nine nine CD cord-005453-4057qib7 13709 4 out out IN cord-005453-4057qib7 13709 5 of of IN cord-005453-4057qib7 13709 6 the the DT cord-005453-4057qib7 13709 7 30 30 CD cord-005453-4057qib7 13709 8 patients patient NNS cord-005453-4057qib7 13709 9 engrafted engraft VBN cord-005453-4057qib7 13709 10 successfully successfully RB cord-005453-4057qib7 13709 11 . . . cord-005453-4057qib7 13710 1 In in IN cord-005453-4057qib7 13710 2 25 25 CD cord-005453-4057qib7 13710 3 of of IN cord-005453-4057qib7 13710 4 the the DT cord-005453-4057qib7 13710 5 evaluated evaluate VBN cord-005453-4057qib7 13710 6 patients patient NNS cord-005453-4057qib7 13710 7 , , , cord-005453-4057qib7 13710 8 the the DT cord-005453-4057qib7 13710 9 median median JJ cord-005453-4057qib7 13710 10 time time NN cord-005453-4057qib7 13710 11 to to IN cord-005453-4057qib7 13710 12 neutrophil neutrophil NN cord-005453-4057qib7 13710 13 engraftment engraftment NN cord-005453-4057qib7 13710 14 was be VBD cord-005453-4057qib7 13710 15 20 20 CD cord-005453-4057qib7 13710 16 days day NNS cord-005453-4057qib7 13710 17 ( ( -LRB- cord-005453-4057qib7 13710 18 range range VBP cord-005453-4057qib7 13710 19 10 10 CD cord-005453-4057qib7 13710 20 - - SYM cord-005453-4057qib7 13710 21 27 27 CD cord-005453-4057qib7 13710 22 ) ) -RRB- cord-005453-4057qib7 13710 23 . . . cord-005453-4057qib7 13711 1 One one CD cord-005453-4057qib7 13711 2 patient patient NN cord-005453-4057qib7 13711 3 experienced experience VBD cord-005453-4057qib7 13711 4 an an DT cord-005453-4057qib7 13711 5 early early JJ cord-005453-4057qib7 13711 6 death death NN cord-005453-4057qib7 13711 7 from from IN cord-005453-4057qib7 13711 8 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 13711 9 shock shock NN cord-005453-4057qib7 13711 10 on on IN cord-005453-4057qib7 13711 11 day day NN cord-005453-4057qib7 13711 12 12 12 CD cord-005453-4057qib7 13711 13 , , , cord-005453-4057qib7 13711 14 before before IN cord-005453-4057qib7 13711 15 neutrophil neutrophil NN cord-005453-4057qib7 13711 16 recovery recovery NN cord-005453-4057qib7 13711 17 , , , cord-005453-4057qib7 13711 18 and and CC cord-005453-4057qib7 13711 19 another another DT cord-005453-4057qib7 13711 20 two two CD cord-005453-4057qib7 13711 21 patients patient NNS cord-005453-4057qib7 13711 22 experienced experience VBD cord-005453-4057qib7 13711 23 primary primary JJ cord-005453-4057qib7 13711 24 graft graft NN cord-005453-4057qib7 13711 25 failure failure NN cord-005453-4057qib7 13711 26 . . . cord-005453-4057qib7 13712 1 Post post JJ cord-005453-4057qib7 13712 2 - - JJ cord-005453-4057qib7 13712 3 transplant transplant NN cord-005453-4057qib7 13712 4 chimerism chimerism NN cord-005453-4057qib7 13712 5 was be VBD cord-005453-4057qib7 13712 6 available available JJ cord-005453-4057qib7 13712 7 for for IN cord-005453-4057qib7 13712 8 22 22 CD cord-005453-4057qib7 13712 9 patients patient NNS cord-005453-4057qib7 13712 10 . . . cord-005453-4057qib7 13713 1 Sixteen sixteen CD cord-005453-4057qib7 13713 2 had have VBD cord-005453-4057qib7 13713 3 complete complete JJ cord-005453-4057qib7 13713 4 chimera chimera NN cord-005453-4057qib7 13713 5 ( ( -LRB- cord-005453-4057qib7 13713 6 > > NFP cord-005453-4057qib7 13713 7 90 90 CD cord-005453-4057qib7 13713 8 % % NN cord-005453-4057qib7 13713 9 chimerism chimerism NN cord-005453-4057qib7 13713 10 ) ) -RRB- cord-005453-4057qib7 13713 11 , , , cord-005453-4057qib7 13713 12 while while IN cord-005453-4057qib7 13713 13 6 6 CD cord-005453-4057qib7 13713 14 patients patient NNS cord-005453-4057qib7 13713 15 presented present VBN cord-005453-4057qib7 13713 16 with with IN cord-005453-4057qib7 13713 17 mixed mixed JJ cord-005453-4057qib7 13713 18 chimerism chimerism NN cord-005453-4057qib7 13713 19 . . . cord-005453-4057qib7 13714 1 Acute acute JJ cord-005453-4057qib7 13714 2 GvHD GvHD NNP cord-005453-4057qib7 13714 3 was be VBD cord-005453-4057qib7 13714 4 observed observe VBN cord-005453-4057qib7 13714 5 in in IN cord-005453-4057qib7 13714 6 9 9 CD cord-005453-4057qib7 13714 7 patients patient NNS cord-005453-4057qib7 13714 8 ( ( -LRB- cord-005453-4057qib7 13714 9 32 32 CD cord-005453-4057qib7 13714 10 % % NN cord-005453-4057qib7 13714 11 ) ) -RRB- cord-005453-4057qib7 13714 12 , , , cord-005453-4057qib7 13714 13 6 6 CD cord-005453-4057qib7 13714 14 of of IN cord-005453-4057qib7 13714 15 which which WDT cord-005453-4057qib7 13714 16 classified classify VBN cord-005453-4057qib7 13714 17 as as IN cord-005453-4057qib7 13714 18 grade grade NN cord-005453-4057qib7 13714 19 IV IV NNP cord-005453-4057qib7 13714 20 . . . cord-005453-4057qib7 13715 1 Five five CD cord-005453-4057qib7 13715 2 patients patient NNS cord-005453-4057qib7 13715 3 developed develop VBD cord-005453-4057qib7 13715 4 chronic chronic JJ cord-005453-4057qib7 13715 5 GvHD GvHD NNP cord-005453-4057qib7 13715 6 , , , cord-005453-4057qib7 13715 7 considered consider VBN cord-005453-4057qib7 13715 8 severe severe JJ cord-005453-4057qib7 13715 9 in in IN cord-005453-4057qib7 13715 10 three three CD cord-005453-4057qib7 13715 11 of of IN cord-005453-4057qib7 13715 12 them -PRON- PRP cord-005453-4057qib7 13715 13 . . . cord-005453-4057qib7 13716 1 Eight eight CD cord-005453-4057qib7 13716 2 patients patient NNS cord-005453-4057qib7 13716 3 died die VBD cord-005453-4057qib7 13716 4 at at IN cord-005453-4057qib7 13716 5 a a DT cord-005453-4057qib7 13716 6 mean mean NN cord-005453-4057qib7 13716 7 of of IN cord-005453-4057qib7 13716 8 155 155 CD cord-005453-4057qib7 13716 9 days day NNS cord-005453-4057qib7 13716 10 ( ( -LRB- cord-005453-4057qib7 13716 11 range range VBP cord-005453-4057qib7 13716 12 12 12 CD cord-005453-4057qib7 13716 13 - - SYM cord-005453-4057qib7 13716 14 728 728 CD cord-005453-4057qib7 13716 15 days day NNS cord-005453-4057qib7 13716 16 ) ) -RRB- cord-005453-4057qib7 13716 17 after after IN cord-005453-4057qib7 13716 18 HSCT HSCT NNP cord-005453-4057qib7 13716 19 and and CC cord-005453-4057qib7 13716 20 the the DT cord-005453-4057qib7 13716 21 main main JJ cord-005453-4057qib7 13716 22 causes cause NNS cord-005453-4057qib7 13716 23 of of IN cord-005453-4057qib7 13716 24 death death NN cord-005453-4057qib7 13716 25 were be VBD cord-005453-4057qib7 13716 26 infections infection NNS cord-005453-4057qib7 13716 27 and and CC cord-005453-4057qib7 13716 28 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 13716 29 disorders disorder NNS cord-005453-4057qib7 13716 30 . . . cord-005453-4057qib7 13717 1 Conclusions conclusion NNS cord-005453-4057qib7 13717 2 : : : cord-005453-4057qib7 13717 3 HSCT HSCT NNP cord-005453-4057qib7 13717 4 is be VBZ cord-005453-4057qib7 13717 5 a a DT cord-005453-4057qib7 13717 6 potentially potentially RB cord-005453-4057qib7 13717 7 curative curative JJ cord-005453-4057qib7 13717 8 treatment treatment NN cord-005453-4057qib7 13717 9 option option NN cord-005453-4057qib7 13717 10 for for IN cord-005453-4057qib7 13717 11 DBA DBA NNP cord-005453-4057qib7 13717 12 . . . cord-005453-4057qib7 13718 1 In in IN cord-005453-4057qib7 13718 2 the the DT cord-005453-4057qib7 13718 3 present present JJ cord-005453-4057qib7 13718 4 study study NN cord-005453-4057qib7 13718 5 , , , cord-005453-4057qib7 13718 6 we -PRON- PRP cord-005453-4057qib7 13718 7 report report VBP cord-005453-4057qib7 13718 8 the the DT cord-005453-4057qib7 13718 9 outcomes outcome NNS cord-005453-4057qib7 13718 10 of of IN cord-005453-4057qib7 13718 11 30 30 CD cord-005453-4057qib7 13718 12 patients patient NNS cord-005453-4057qib7 13718 13 with with IN cord-005453-4057qib7 13718 14 DBA DBA NNP cord-005453-4057qib7 13718 15 transplanted transplant VBN cord-005453-4057qib7 13718 16 in in IN cord-005453-4057qib7 13718 17 Brazil Brazil NNP cord-005453-4057qib7 13718 18 with with IN cord-005453-4057qib7 13718 19 a a DT cord-005453-4057qib7 13718 20 OS os NN cord-005453-4057qib7 13718 21 of of IN cord-005453-4057qib7 13718 22 71 71 CD cord-005453-4057qib7 13718 23 % % NN cord-005453-4057qib7 13718 24 , , , cord-005453-4057qib7 13718 25 with with IN cord-005453-4057qib7 13718 26 better well JJR cord-005453-4057qib7 13718 27 results result NNS cord-005453-4057qib7 13718 28 in in IN cord-005453-4057qib7 13718 29 MRD MRD NNP cord-005453-4057qib7 13718 30 compared compare VBN cord-005453-4057qib7 13718 31 to to IN cord-005453-4057qib7 13718 32 MUD mud NN cord-005453-4057qib7 13718 33 , , , cord-005453-4057qib7 13718 34 as as IN cord-005453-4057qib7 13718 35 expected expect VBN cord-005453-4057qib7 13718 36 . . . cord-005453-4057qib7 13719 1 Despite despite IN cord-005453-4057qib7 13719 2 the the DT cord-005453-4057qib7 13719 3 small small JJ cord-005453-4057qib7 13719 4 numbers number NNS cord-005453-4057qib7 13719 5 , , , cord-005453-4057qib7 13719 6 we -PRON- PRP cord-005453-4057qib7 13719 7 observed observe VBD cord-005453-4057qib7 13719 8 lower low JJR cord-005453-4057qib7 13719 9 survival survival NN cord-005453-4057qib7 13719 10 after after IN cord-005453-4057qib7 13719 11 MUD mud NN cord-005453-4057qib7 13719 12 / / SYM cord-005453-4057qib7 13719 13 MMUD MMUD NNP cord-005453-4057qib7 13719 14 UCB UCB NNP cord-005453-4057qib7 13719 15 transplantation transplantation NN cord-005453-4057qib7 13719 16 . . . cord-005453-4057qib7 13720 1 Since since IN cord-005453-4057qib7 13720 2 DBA DBA NNP cord-005453-4057qib7 13720 3 is be VBZ cord-005453-4057qib7 13720 4 a a DT cord-005453-4057qib7 13720 5 rare rare JJ cord-005453-4057qib7 13720 6 disease disease NN cord-005453-4057qib7 13720 7 , , , cord-005453-4057qib7 13720 8 international international JJ cord-005453-4057qib7 13720 9 collaborative collaborative JJ cord-005453-4057qib7 13720 10 studies study NNS cord-005453-4057qib7 13720 11 are be VBP cord-005453-4057qib7 13720 12 essential essential JJ cord-005453-4057qib7 13720 13 to to TO cord-005453-4057qib7 13720 14 better better RB cord-005453-4057qib7 13720 15 understand understand VB cord-005453-4057qib7 13720 16 the the DT cord-005453-4057qib7 13720 17 benefits benefit NNS cord-005453-4057qib7 13720 18 of of IN cord-005453-4057qib7 13720 19 the the DT cord-005453-4057qib7 13720 20 HSCT HSCT NNP cord-005453-4057qib7 13720 21 in in IN cord-005453-4057qib7 13720 22 the the DT cord-005453-4057qib7 13720 23 treatment treatment NN cord-005453-4057qib7 13720 24 of of IN cord-005453-4057qib7 13720 25 these these DT cord-005453-4057qib7 13720 26 patients patient NNS cord-005453-4057qib7 13720 27 . . . cord-005453-4057qib7 13721 1 Disclosure disclosure NN cord-005453-4057qib7 13721 2 : : : cord-005453-4057qib7 13721 3 Nothing nothing NN cord-005453-4057qib7 13721 4 to to TO cord-005453-4057qib7 13721 5 declare declare VB cord-005453-4057qib7 13721 6 P627 P627 NNP cord-005453-4057qib7 13721 7 Treatment Treatment NNP cord-005453-4057qib7 13721 8 of of IN cord-005453-4057qib7 13721 9 the the DT cord-005453-4057qib7 13721 10 obliterant obliterant JJ cord-005453-4057qib7 13721 11 bronchiolitis bronchiolitis NN cord-005453-4057qib7 13721 12 in in IN cord-005453-4057qib7 13721 13 pediatric pediatric JJ cord-005453-4057qib7 13721 14 allogeneic allogeneic NN cord-005453-4057qib7 13721 15 recipients recipient NNS cord-005453-4057qib7 13721 16 : : : cord-005453-4057qib7 13722 1 Two two CD cord-005453-4057qib7 13722 2 periods period NNS cord-005453-4057qib7 13722 3 compared compare VBN cord-005453-4057qib7 13722 4 Results result NNS cord-005453-4057qib7 13722 5 : : : cord-005453-4057qib7 13722 6 In in IN cord-005453-4057qib7 13722 7 group group NN cord-005453-4057qib7 13722 8 1 1 CD cord-005453-4057qib7 13722 9 , , , cord-005453-4057qib7 13722 10 the the DT cord-005453-4057qib7 13722 11 therapies therapy NNS cord-005453-4057qib7 13722 12 administered administer VBN cord-005453-4057qib7 13722 13 for for IN cord-005453-4057qib7 13722 14 BO BO NNP cord-005453-4057qib7 13722 15 included include VBD cord-005453-4057qib7 13722 16 prolonged prolonged JJ cord-005453-4057qib7 13722 17 treatment treatment NN cord-005453-4057qib7 13722 18 with with IN cord-005453-4057qib7 13722 19 steroids steroid NNS cord-005453-4057qib7 13722 20 in in IN cord-005453-4057qib7 13722 21 all all DT cord-005453-4057qib7 13722 22 patients patient NNS cord-005453-4057qib7 13722 23 , , , cord-005453-4057qib7 13722 24 anti anti JJ cord-005453-4057qib7 13722 25 - - NNP cord-005453-4057qib7 13722 26 TNF TNF NNP cord-005453-4057qib7 13722 27 in in IN cord-005453-4057qib7 13722 28 1 1 CD cord-005453-4057qib7 13722 29 , , , cord-005453-4057qib7 13722 30 azatioprine azatioprine NN cord-005453-4057qib7 13722 31 in in IN cord-005453-4057qib7 13722 32 4 4 CD cord-005453-4057qib7 13722 33 ; ; : cord-005453-4057qib7 13722 34 while while IN cord-005453-4057qib7 13722 35 in in IN cord-005453-4057qib7 13722 36 the the DT cord-005453-4057qib7 13722 37 group group NN cord-005453-4057qib7 13722 38 2 2 CD cord-005453-4057qib7 13722 39 , , , cord-005453-4057qib7 13722 40 all all DT cord-005453-4057qib7 13722 41 patients patient NNS cord-005453-4057qib7 13722 42 received receive VBD cord-005453-4057qib7 13722 43 IMA IMA NNP cord-005453-4057qib7 13722 44 , , , cord-005453-4057qib7 13722 45 montelukast montelukast NN cord-005453-4057qib7 13722 46 and and CC cord-005453-4057qib7 13722 47 azitromicin azitromicin NNS cord-005453-4057qib7 13722 48 , , , cord-005453-4057qib7 13722 49 and and CC cord-005453-4057qib7 13722 50 4 4 CD cord-005453-4057qib7 13722 51 received receive VBD cord-005453-4057qib7 13722 52 i.v i.v NNP cord-005453-4057qib7 13722 53 . . . cord-005453-4057qib7 13722 54 MPD MPD NNP cord-005453-4057qib7 13722 55 . . . cord-005453-4057qib7 13723 1 The the DT cord-005453-4057qib7 13723 2 median median JJ cord-005453-4057qib7 13723 3 duration duration NN cord-005453-4057qib7 13723 4 of of IN cord-005453-4057qib7 13723 5 Imatinib Imatinib NNP cord-005453-4057qib7 13723 6 therapy therapy NN cord-005453-4057qib7 13723 7 was be VBD cord-005453-4057qib7 13723 8 4 4 CD cord-005453-4057qib7 13723 9 years year NNS cord-005453-4057qib7 13723 10 ( ( -LRB- cord-005453-4057qib7 13723 11 0.3 0.3 CD cord-005453-4057qib7 13723 12 - - SYM cord-005453-4057qib7 13723 13 7.1 7.1 CD cord-005453-4057qib7 13723 14 years year NNS cord-005453-4057qib7 13723 15 ) ) -RRB- cord-005453-4057qib7 13723 16 . . . cord-005453-4057qib7 13724 1 After after IN cord-005453-4057qib7 13724 2 a a DT cord-005453-4057qib7 13724 3 median median JJ cord-005453-4057qib7 13724 4 follow follow NN cord-005453-4057qib7 13724 5 - - HYPH cord-005453-4057qib7 13724 6 up up NN cord-005453-4057qib7 13724 7 of of IN cord-005453-4057qib7 13724 8 4.4 4.4 CD cord-005453-4057qib7 13724 9 years year NNS cord-005453-4057qib7 13724 10 ( ( -LRB- cord-005453-4057qib7 13724 11 range range VBP cord-005453-4057qib7 13724 12 0.5 0.5 CD cord-005453-4057qib7 13724 13 - - HYPH cord-005453-4057qib7 13724 14 12.1 12.1 CD cord-005453-4057qib7 13724 15 yrs yr NNS cord-005453-4057qib7 13724 16 ) ) -RRB- cord-005453-4057qib7 13724 17 , , , cord-005453-4057qib7 13724 18 9/11 9/11 CD cord-005453-4057qib7 13724 19 patients patient NNS cord-005453-4057qib7 13724 20 of of IN cord-005453-4057qib7 13724 21 group group NN cord-005453-4057qib7 13724 22 1 1 CD cord-005453-4057qib7 13724 23 ( ( -LRB- cord-005453-4057qib7 13724 24 82 82 CD cord-005453-4057qib7 13724 25 % % NN cord-005453-4057qib7 13724 26 ) ) -RRB- cord-005453-4057qib7 13724 27 died die VBD cord-005453-4057qib7 13724 28 with with IN cord-005453-4057qib7 13724 29 BO BO NNP cord-005453-4057qib7 13724 30 in in IN cord-005453-4057qib7 13724 31 progress progress NN cord-005453-4057qib7 13724 32 for for IN cord-005453-4057qib7 13724 33 transplant transplant NN cord-005453-4057qib7 13724 34 - - HYPH cord-005453-4057qib7 13724 35 related relate VBN cord-005453-4057qib7 13724 36 causes cause NNS cord-005453-4057qib7 13724 37 . . . cord-005453-4057qib7 13725 1 While while IN cord-005453-4057qib7 13725 2 in in IN cord-005453-4057qib7 13725 3 the the DT cord-005453-4057qib7 13725 4 group group NN cord-005453-4057qib7 13725 5 2 2 CD cord-005453-4057qib7 13725 6 , , , cord-005453-4057qib7 13725 7 2/14 2/14 CD cord-005453-4057qib7 13725 8 ( ( -LRB- cord-005453-4057qib7 13725 9 14 14 CD cord-005453-4057qib7 13725 10 % % NN cord-005453-4057qib7 13725 11 ) ) -RRB- cord-005453-4057qib7 13725 12 died die VBD cord-005453-4057qib7 13725 13 in in IN cord-005453-4057qib7 13725 14 presence presence NN cord-005453-4057qib7 13725 15 of of IN cord-005453-4057qib7 13725 16 worsening worsen VBG cord-005453-4057qib7 13725 17 BO BO NNP cord-005453-4057qib7 13725 18 . . . cord-005453-4057qib7 13726 1 The the DT cord-005453-4057qib7 13726 2 estimated estimate VBN cord-005453-4057qib7 13726 3 OS os NN cord-005453-4057qib7 13726 4 at at IN cord-005453-4057qib7 13726 5 1 1 CD cord-005453-4057qib7 13726 6 year year NN cord-005453-4057qib7 13726 7 after after IN cord-005453-4057qib7 13726 8 HSCT HSCT NNP cord-005453-4057qib7 13726 9 was be VBD cord-005453-4057qib7 13726 10 75 75 CD cord-005453-4057qib7 13726 11 % % NN cord-005453-4057qib7 13726 12 ( ( -LRB- cord-005453-4057qib7 13726 13 95 95 CD cord-005453-4057qib7 13726 14 % % NN cord-005453-4057qib7 13726 15 CI ci NN cord-005453-4057qib7 13726 16 ; ; : cord-005453-4057qib7 13726 17 50 50 CD cord-005453-4057qib7 13726 18 - - SYM cord-005453-4057qib7 13726 19 89 89 CD cord-005453-4057qib7 13726 20 ) ) -RRB- cord-005453-4057qib7 13726 21 in in IN cord-005453-4057qib7 13726 22 group group NN cord-005453-4057qib7 13726 23 1 1 CD cord-005453-4057qib7 13726 24 and and CC cord-005453-4057qib7 13726 25 83 83 CD cord-005453-4057qib7 13726 26 % % NN cord-005453-4057qib7 13726 27 ( ( -LRB- cord-005453-4057qib7 13726 28 95 95 CD cord-005453-4057qib7 13726 29 % % NN cord-005453-4057qib7 13726 30 CI CI NNP cord-005453-4057qib7 13726 31 , , , cord-005453-4057qib7 13726 32 27 27 CD cord-005453-4057qib7 13726 33 - - SYM cord-005453-4057qib7 13726 34 97 97 CD cord-005453-4057qib7 13726 35 ) ) -RRB- cord-005453-4057qib7 13726 36 in in IN cord-005453-4057qib7 13726 37 group group NN cord-005453-4057qib7 13726 38 2 2 CD cord-005453-4057qib7 13726 39 ( ( -LRB- cord-005453-4057qib7 13726 40 p=0.103 p=0.103 NNP cord-005453-4057qib7 13726 41 ) ) -RRB- cord-005453-4057qib7 13727 1 ( ( -LRB- cord-005453-4057qib7 13727 2 Figure figure NN cord-005453-4057qib7 13727 3 1 1 CD cord-005453-4057qib7 13727 4 ) ) -RRB- cord-005453-4057qib7 13727 5 , , , cord-005453-4057qib7 13727 6 while while IN cord-005453-4057qib7 13727 7 the the DT cord-005453-4057qib7 13727 8 OS OS NNP cord-005453-4057qib7 13727 9 after after IN cord-005453-4057qib7 13727 10 4 4 CD cord-005453-4057qib7 13727 11 year year NN cord-005453-4057qib7 13727 12 decreased decrease VBD cord-005453-4057qib7 13727 13 at at IN cord-005453-4057qib7 13727 14 42 42 CD cord-005453-4057qib7 13727 15 % % NN cord-005453-4057qib7 13727 16 ( ( -LRB- cord-005453-4057qib7 13727 17 95 95 CD cord-005453-4057qib7 13727 18 % % NN cord-005453-4057qib7 13727 19 CI CI NNP cord-005453-4057qib7 13727 20 ; ; : cord-005453-4057qib7 13727 21 16 16 CD cord-005453-4057qib7 13727 22 - - SYM cord-005453-4057qib7 13727 23 66 66 CD cord-005453-4057qib7 13727 24 ) ) -RRB- cord-005453-4057qib7 13727 25 in in IN cord-005453-4057qib7 13727 26 the the DT cord-005453-4057qib7 13727 27 group group NN cord-005453-4057qib7 13727 28 1 1 CD cord-005453-4057qib7 13727 29 while while NN cord-005453-4057qib7 13727 30 remained remain VBD cord-005453-4057qib7 13727 31 stable stable JJ cord-005453-4057qib7 13727 32 in in IN cord-005453-4057qib7 13727 33 the the DT cord-005453-4057qib7 13727 34 group group NN cord-005453-4057qib7 13727 35 2 2 CD cord-005453-4057qib7 13727 36 . . . cord-005453-4057qib7 13728 1 Conclusions conclusion NNS cord-005453-4057qib7 13728 2 : : : cord-005453-4057qib7 13728 3 this this DT cord-005453-4057qib7 13728 4 experience experience NN cord-005453-4057qib7 13728 5 shows show VBZ cord-005453-4057qib7 13728 6 a a DT cord-005453-4057qib7 13728 7 relevant relevant JJ cord-005453-4057qib7 13728 8 improving improving NN cord-005453-4057qib7 13728 9 in in IN cord-005453-4057qib7 13728 10 prognosis prognosis NN cord-005453-4057qib7 13728 11 of of IN cord-005453-4057qib7 13728 12 children child NNS cord-005453-4057qib7 13728 13 with with IN cord-005453-4057qib7 13728 14 BO BO NNP cord-005453-4057qib7 13728 15 with with IN cord-005453-4057qib7 13728 16 the the DT cord-005453-4057qib7 13728 17 use use NN cord-005453-4057qib7 13728 18 of of IN cord-005453-4057qib7 13728 19 this this DT cord-005453-4057qib7 13728 20 protocol protocol NN cord-005453-4057qib7 13728 21 including include VBG cord-005453-4057qib7 13728 22 IMA IMA NNP cord-005453-4057qib7 13728 23 , , , cord-005453-4057qib7 13728 24 since since IN cord-005453-4057qib7 13728 25 the the DT cord-005453-4057qib7 13728 26 significant significant JJ cord-005453-4057qib7 13728 27 improving improving NN cord-005453-4057qib7 13728 28 of of IN cord-005453-4057qib7 13728 29 survival survival NN cord-005453-4057qib7 13728 30 obtained obtain VBN cord-005453-4057qib7 13728 31 , , , cord-005453-4057qib7 13728 32 confirming confirm VBG cord-005453-4057qib7 13728 33 as as IN cord-005453-4057qib7 13728 34 reported report VBN cord-005453-4057qib7 13728 35 in in IN cord-005453-4057qib7 13728 36 adult adult NN cord-005453-4057qib7 13728 37 populations population NNS cord-005453-4057qib7 13728 38 . . . cord-005453-4057qib7 13729 1 Disclosure disclosure NN cord-005453-4057qib7 13729 2 Results result NNS cord-005453-4057qib7 13730 1 : : : cord-005453-4057qib7 13730 2 We -PRON- PRP cord-005453-4057qib7 13730 3 presented present VBD cord-005453-4057qib7 13730 4 20 20 CD cord-005453-4057qib7 13730 5 patients patient NNS cord-005453-4057qib7 13730 6 with with IN cord-005453-4057qib7 13730 7 PRES PRES NNP cord-005453-4057qib7 13730 8 , , , cord-005453-4057qib7 13730 9 age age NN cord-005453-4057qib7 13730 10 ranging range VBG cord-005453-4057qib7 13730 11 from from IN cord-005453-4057qib7 13730 12 2 2 CD cord-005453-4057qib7 13730 13 months month NNS cord-005453-4057qib7 13730 14 to to IN cord-005453-4057qib7 13730 15 19 19 CD cord-005453-4057qib7 13730 16 years year NNS cord-005453-4057qib7 13730 17 with with IN cord-005453-4057qib7 13730 18 a a DT cord-005453-4057qib7 13730 19 average average NN cord-005453-4057qib7 13730 20 of of IN cord-005453-4057qib7 13730 21 9.5 9.5 CD cord-005453-4057qib7 13730 22 years year NNS cord-005453-4057qib7 13730 23 . . . cord-005453-4057qib7 13731 1 There there EX cord-005453-4057qib7 13731 2 were be VBD cord-005453-4057qib7 13731 3 ten ten CD cord-005453-4057qib7 13731 4 patients patient NNS cord-005453-4057qib7 13731 5 with with IN cord-005453-4057qib7 13731 6 thalassemia thalassemia NN cord-005453-4057qib7 13731 7 major major JJ cord-005453-4057qib7 13731 8 , , , cord-005453-4057qib7 13731 9 two two CD cord-005453-4057qib7 13731 10 patient patient JJ cord-005453-4057qib7 13731 11 with with IN cord-005453-4057qib7 13731 12 acute acute JJ cord-005453-4057qib7 13731 13 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13731 14 leukemia leukemia NN cord-005453-4057qib7 13731 15 , , , cord-005453-4057qib7 13731 16 three three CD cord-005453-4057qib7 13731 17 patients patient NNS cord-005453-4057qib7 13731 18 with with IN cord-005453-4057qib7 13731 19 sickle sickle NN cord-005453-4057qib7 13731 20 cell cell NN cord-005453-4057qib7 13731 21 disease disease NN cord-005453-4057qib7 13731 22 and and CC cord-005453-4057qib7 13731 23 one one CD cord-005453-4057qib7 13731 24 patient patient NN cord-005453-4057qib7 13731 25 with with IN cord-005453-4057qib7 13731 26 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 13731 27 syndrome syndrome NN cord-005453-4057qib7 13731 28 , , , cord-005453-4057qib7 13731 29 one one CD cord-005453-4057qib7 13731 30 patient patient NN cord-005453-4057qib7 13731 31 with with IN cord-005453-4057qib7 13731 32 immune immune JJ cord-005453-4057qib7 13731 33 deficiency deficiency NN cord-005453-4057qib7 13731 34 , , , cord-005453-4057qib7 13731 35 two two CD cord-005453-4057qib7 13731 36 patients patient NNS cord-005453-4057qib7 13731 37 with with IN cord-005453-4057qib7 13731 38 acute acute JJ cord-005453-4057qib7 13731 39 miyeloid miyeloid NNP cord-005453-4057qib7 13731 40 leukemia leukemia NN cord-005453-4057qib7 13731 41 , , , cord-005453-4057qib7 13731 42 one one CD cord-005453-4057qib7 13731 43 patient patient NN cord-005453-4057qib7 13731 44 with with IN cord-005453-4057qib7 13731 45 aplastic aplastic JJ cord-005453-4057qib7 13731 46 anemia anemia NN cord-005453-4057qib7 13731 47 . . . cord-005453-4057qib7 13732 1 Ten ten CD cord-005453-4057qib7 13732 2 patients patient NNS cord-005453-4057qib7 13732 3 were be VBD cord-005453-4057qib7 13732 4 males male NNS cord-005453-4057qib7 13732 5 , , , cord-005453-4057qib7 13732 6 ten ten CD cord-005453-4057qib7 13732 7 were be VBD cord-005453-4057qib7 13732 8 female female JJ cord-005453-4057qib7 13732 9 . . . cord-005453-4057qib7 13733 1 All all DT cord-005453-4057qib7 13733 2 patients patient NNS cord-005453-4057qib7 13733 3 were be VBD cord-005453-4057qib7 13733 4 treated treat VBN cord-005453-4057qib7 13733 5 with with IN cord-005453-4057qib7 13733 6 CsA csa NN cord-005453-4057qib7 13733 7 or or CC cord-005453-4057qib7 13733 8 tacrolimus tacrolimus NN cord-005453-4057qib7 13733 9 and and CC cord-005453-4057qib7 13733 10 metilprednisolone metilprednisolone NNP cord-005453-4057qib7 13733 11 for for IN cord-005453-4057qib7 13733 12 the the DT cord-005453-4057qib7 13733 13 prophylasix prophylasix NN cord-005453-4057qib7 13733 14 of of IN cord-005453-4057qib7 13733 15 GVHD GVHD NNP cord-005453-4057qib7 13733 16 . . . cord-005453-4057qib7 13734 1 PRES PRES NNP cord-005453-4057qib7 13734 2 occurred occur VBD cord-005453-4057qib7 13734 3 at at IN cord-005453-4057qib7 13734 4 a a DT cord-005453-4057qib7 13734 5 median median NN cord-005453-4057qib7 13734 6 of of IN cord-005453-4057qib7 13734 7 90 90 CD cord-005453-4057qib7 13734 8 days day NNS cord-005453-4057qib7 13734 9 ( ( -LRB- cord-005453-4057qib7 13734 10 range range NNP cord-005453-4057qib7 13734 11 5 5 CD cord-005453-4057qib7 13734 12 - - SYM cord-005453-4057qib7 13734 13 625 625 CD cord-005453-4057qib7 13734 14 ) ) -RRB- cord-005453-4057qib7 13734 15 . . . cord-005453-4057qib7 13735 1 Clinical clinical JJ cord-005453-4057qib7 13735 2 findings finding NNS cord-005453-4057qib7 13735 3 at at IN cord-005453-4057qib7 13735 4 onset onset NN cord-005453-4057qib7 13735 5 of of IN cord-005453-4057qib7 13735 6 leukoencephalopathy leukoencephalopathy NNP cord-005453-4057qib7 13735 7 were be VBD cord-005453-4057qib7 13735 8 hypertension hypertension NN cord-005453-4057qib7 13735 9 , , , cord-005453-4057qib7 13735 10 headache headache NN cord-005453-4057qib7 13735 11 , , , cord-005453-4057qib7 13735 12 seizures seizure NNS cord-005453-4057qib7 13735 13 , , , cord-005453-4057qib7 13735 14 visual visual JJ cord-005453-4057qib7 13735 15 disturbance disturbance NN cord-005453-4057qib7 13735 16 , , , cord-005453-4057qib7 13735 17 and and CC cord-005453-4057qib7 13735 18 altered alter VBN cord-005453-4057qib7 13735 19 mental mental JJ cord-005453-4057qib7 13735 20 function function NN cord-005453-4057qib7 13735 21 . . . cord-005453-4057qib7 13736 1 Eighteen eighteen CD cord-005453-4057qib7 13736 2 patients patient NNS cord-005453-4057qib7 13736 3 alive alive JJ cord-005453-4057qib7 13736 4 with with IN cord-005453-4057qib7 13736 5 normal normal JJ cord-005453-4057qib7 13736 6 neurological neurological JJ cord-005453-4057qib7 13736 7 status status NN cord-005453-4057qib7 13736 8 . . . cord-005453-4057qib7 13737 1 MRI MRI NNP cord-005453-4057qib7 13737 2 showed show VBD cord-005453-4057qib7 13737 3 abnormalities abnormality NNS cord-005453-4057qib7 13737 4 in in IN cord-005453-4057qib7 13737 5 all all DT cord-005453-4057qib7 13737 6 patients patient NNS cord-005453-4057qib7 13737 7 including include VBG cord-005453-4057qib7 13737 8 patchy patchy JJ cord-005453-4057qib7 13737 9 bilateral bilateral JJ cord-005453-4057qib7 13737 10 cortical cortical JJ cord-005453-4057qib7 13737 11 and and CC cord-005453-4057qib7 13737 12 subcortical subcortical JJ cord-005453-4057qib7 13737 13 lesions lesion NNS cord-005453-4057qib7 13737 14 , , , cord-005453-4057qib7 13737 15 especially especially RB cord-005453-4057qib7 13737 16 in in IN cord-005453-4057qib7 13737 17 parieto parieto NN cord-005453-4057qib7 13737 18 - - HYPH cord-005453-4057qib7 13737 19 occipital occipital JJ cord-005453-4057qib7 13737 20 lobes lobe NNS cord-005453-4057qib7 13737 21 . . . cord-005453-4057qib7 13738 1 Conclusions conclusion NNS cord-005453-4057qib7 13738 2 : : : cord-005453-4057qib7 13739 1 BMT BMT NNP cord-005453-4057qib7 13739 2 is be VBZ cord-005453-4057qib7 13739 3 associated associate VBN cord-005453-4057qib7 13739 4 with with IN cord-005453-4057qib7 13739 5 several several JJ cord-005453-4057qib7 13739 6 neurological neurological JJ cord-005453-4057qib7 13739 7 complications complication NNS cord-005453-4057qib7 13739 8 that that WDT cord-005453-4057qib7 13739 9 may may MD cord-005453-4057qib7 13739 10 be be VB cord-005453-4057qib7 13739 11 underlying underlie VBG cord-005453-4057qib7 13739 12 diseases disease NNS cord-005453-4057qib7 13739 13 , , , cord-005453-4057qib7 13739 14 BMT BMT NNP cord-005453-4057qib7 13739 15 procedure procedure NN cord-005453-4057qib7 13739 16 , , , cord-005453-4057qib7 13739 17 and and CC cord-005453-4057qib7 13739 18 severe severe JJ cord-005453-4057qib7 13739 19 immunosupression immunosupression NN cord-005453-4057qib7 13739 20 . . . cord-005453-4057qib7 13740 1 PRES PRES NNP cord-005453-4057qib7 13740 2 is be VBZ cord-005453-4057qib7 13740 3 an an DT cord-005453-4057qib7 13740 4 uncommon uncommon JJ cord-005453-4057qib7 13740 5 but but CC cord-005453-4057qib7 13740 6 serious serious JJ cord-005453-4057qib7 13740 7 complication complication NN cord-005453-4057qib7 13740 8 after after IN cord-005453-4057qib7 13740 9 BMT BMT NNP cord-005453-4057qib7 13740 10 . . . cord-005453-4057qib7 13741 1 We -PRON- PRP cord-005453-4057qib7 13741 2 report report VBP cord-005453-4057qib7 13741 3 20 20 CD cord-005453-4057qib7 13741 4 cases case NNS cord-005453-4057qib7 13741 5 of of IN cord-005453-4057qib7 13741 6 PRES PRES NNP cord-005453-4057qib7 13741 7 who who WP cord-005453-4057qib7 13741 8 received receive VBD cord-005453-4057qib7 13741 9 allogeneic allogeneic NN cord-005453-4057qib7 13741 10 BMT BMT NNP cord-005453-4057qib7 13741 11 for for IN cord-005453-4057qib7 13741 12 thalassemia thalassemia NN cord-005453-4057qib7 13741 13 major major JJ cord-005453-4057qib7 13741 14 to to TO cord-005453-4057qib7 13741 15 emphasize emphasize VB cord-005453-4057qib7 13741 16 the the DT cord-005453-4057qib7 13741 17 importance importance NN cord-005453-4057qib7 13741 18 of of IN cord-005453-4057qib7 13741 19 early early JJ cord-005453-4057qib7 13741 20 recognition recognition NN cord-005453-4057qib7 13741 21 and and CC cord-005453-4057qib7 13741 22 institution institution NN cord-005453-4057qib7 13741 23 of of IN cord-005453-4057qib7 13741 24 appropriate appropriate JJ cord-005453-4057qib7 13741 25 management management NN cord-005453-4057qib7 13741 26 of of IN cord-005453-4057qib7 13741 27 PRES PRES NNP cord-005453-4057qib7 13741 28 during during IN cord-005453-4057qib7 13741 29 BMT BMT NNP cord-005453-4057qib7 13741 30 . . . cord-005453-4057qib7 13742 1 Disclosure disclosure NN cord-005453-4057qib7 13742 2 : : : cord-005453-4057qib7 13742 3 Nothing nothing NN cord-005453-4057qib7 13742 4 to to TO cord-005453-4057qib7 13742 5 declare declare VB cord-005453-4057qib7 13742 6 P631 p631 CD cord-005453-4057qib7 13743 1 Continuous continuous JJ cord-005453-4057qib7 13743 2 complete complete JJ cord-005453-4057qib7 13743 3 molecular molecular JJ cord-005453-4057qib7 13743 4 remission remission NN cord-005453-4057qib7 13743 5 using use VBG cord-005453-4057qib7 13743 6 three three CD cord-005453-4057qib7 13743 7 different different JJ cord-005453-4057qib7 13743 8 monoclonal monoclonal JJ cord-005453-4057qib7 13743 9 antibodies antibody NNS cord-005453-4057qib7 13743 10 followed follow VBN cord-005453-4057qib7 13743 11 by by IN cord-005453-4057qib7 13743 12 allogeneic allogeneic IN cord-005453-4057qib7 13743 13 bone bone NN cord-005453-4057qib7 13743 14 marrow marrow NN cord-005453-4057qib7 13743 15 transplantation transplantation NN cord-005453-4057qib7 13743 16 in in IN cord-005453-4057qib7 13743 17 an an DT cord-005453-4057qib7 13743 18 infant infant NN cord-005453-4057qib7 13743 19 with with IN cord-005453-4057qib7 13743 20 chemotherapy chemotherapy NN cord-005453-4057qib7 13743 21 - - HYPH cord-005453-4057qib7 13743 22 refractory refractory JJ cord-005453-4057qib7 13743 23 acute acute JJ cord-005453-4057qib7 13743 24 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13743 25 leukemia leukemia NN cord-005453-4057qib7 13743 26 Bernd Bernd NNP cord-005453-4057qib7 13743 27 Gruhn Gruhn NNP cord-005453-4057qib7 13743 28 1 1 CD cord-005453-4057qib7 13744 1 , , , cord-005453-4057qib7 13744 2 Susan Susan NNP cord-005453-4057qib7 13744 3 Wittig Wittig NNP cord-005453-4057qib7 13744 4 1 1 CD cord-005453-4057qib7 13744 5 , , , cord-005453-4057qib7 13744 6 Thomas Thomas NNP cord-005453-4057qib7 13744 7 Ernst Ernst NNP cord-005453-4057qib7 13744 8 1 1 CD cord-005453-4057qib7 13744 9 , , , cord-005453-4057qib7 13744 10 Jana Jana NNP cord-005453-4057qib7 13744 11 Ernst Ernst NNP cord-005453-4057qib7 13744 12 1 1 CD cord-005453-4057qib7 13744 13 1 1 CD cord-005453-4057qib7 13744 14 University University NNP cord-005453-4057qib7 13744 15 of of IN cord-005453-4057qib7 13744 16 Jena Jena NNP cord-005453-4057qib7 13744 17 , , , cord-005453-4057qib7 13744 18 Jena Jena NNP cord-005453-4057qib7 13744 19 , , , cord-005453-4057qib7 13744 20 Germany Germany NNP cord-005453-4057qib7 13744 21 , , , cord-005453-4057qib7 13744 22 Background background NN cord-005453-4057qib7 13744 23 : : : cord-005453-4057qib7 13745 1 A a DT cord-005453-4057qib7 13745 2 10-week 10-week JJ cord-005453-4057qib7 13745 3 - - HYPH cord-005453-4057qib7 13745 4 old old JJ cord-005453-4057qib7 13745 5 infant infant NN cord-005453-4057qib7 13745 6 was be VBD cord-005453-4057qib7 13745 7 diagnosed diagnose VBN cord-005453-4057qib7 13745 8 with with IN cord-005453-4057qib7 13745 9 very very RB cord-005453-4057qib7 13745 10 immature immature JJ cord-005453-4057qib7 13745 11 acute acute JJ cord-005453-4057qib7 13745 12 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13745 13 leukemia leukemia NN cord-005453-4057qib7 13745 14 ( ( -LRB- cord-005453-4057qib7 13745 15 ALL all DT cord-005453-4057qib7 13745 16 ) ) -RRB- cord-005453-4057qib7 13745 17 with with IN cord-005453-4057qib7 13745 18 myeloid myeloid JJ cord-005453-4057qib7 13745 19 markers marker NNS cord-005453-4057qib7 13745 20 in in IN cord-005453-4057qib7 13745 21 a a DT cord-005453-4057qib7 13745 22 foreign foreign JJ cord-005453-4057qib7 13745 23 university university NN cord-005453-4057qib7 13745 24 hospital hospital NN cord-005453-4057qib7 13745 25 . . . cord-005453-4057qib7 13746 1 At at IN cord-005453-4057qib7 13746 2 the the DT cord-005453-4057qib7 13746 3 end end NN cord-005453-4057qib7 13746 4 of of IN cord-005453-4057qib7 13746 5 induction induction NN cord-005453-4057qib7 13746 6 therapy therapy NN cord-005453-4057qib7 13746 7 according accord VBG cord-005453-4057qib7 13746 8 to to IN cord-005453-4057qib7 13746 9 the the DT cord-005453-4057qib7 13746 10 current current JJ cord-005453-4057qib7 13746 11 LAL LAL NNP cord-005453-4057qib7 13746 12 / / SYM cord-005453-4057qib7 13746 13 SHOP SHOP NNP cord-005453-4057qib7 13746 14 protocol protocol NN cord-005453-4057qib7 13746 15 10 10 CD cord-005453-4057qib7 13746 16 % % NN cord-005453-4057qib7 13746 17 leukemic leukemic JJ cord-005453-4057qib7 13746 18 cells cell NNS cord-005453-4057qib7 13746 19 were be VBD cord-005453-4057qib7 13746 20 detectable detectable JJ cord-005453-4057qib7 13746 21 in in IN cord-005453-4057qib7 13746 22 the the DT cord-005453-4057qib7 13746 23 bone bone NN cord-005453-4057qib7 13746 24 marrow marrow NN cord-005453-4057qib7 13746 25 . . . cord-005453-4057qib7 13747 1 Treatment treatment NN cord-005453-4057qib7 13747 2 was be VBD cord-005453-4057qib7 13747 3 changed change VBN cord-005453-4057qib7 13747 4 to to IN cord-005453-4057qib7 13747 5 fludarabine fludarabine VB cord-005453-4057qib7 13747 6 , , , cord-005453-4057qib7 13747 7 cytarabine cytarabine NN cord-005453-4057qib7 13747 8 and and CC cord-005453-4057qib7 13747 9 granulocyte granulocyte NN cord-005453-4057qib7 13747 10 colony colony NN cord-005453-4057qib7 13747 11 - - HYPH cord-005453-4057qib7 13747 12 stimulating stimulate VBG cord-005453-4057qib7 13747 13 factor factor NN cord-005453-4057qib7 13747 14 ( ( -LRB- cord-005453-4057qib7 13747 15 FLAG flag NN cord-005453-4057qib7 13747 16 ) ) -RRB- cord-005453-4057qib7 13747 17 in in IN cord-005453-4057qib7 13747 18 combination combination NN cord-005453-4057qib7 13747 19 with with IN cord-005453-4057qib7 13747 20 liposomal liposomal JJ cord-005453-4057qib7 13747 21 doxorubicin doxorubicin NN cord-005453-4057qib7 13747 22 . . . cord-005453-4057qib7 13748 1 After after IN cord-005453-4057qib7 13748 2 this this DT cord-005453-4057qib7 13748 3 re re NN cord-005453-4057qib7 13748 4 - - NN cord-005453-4057qib7 13748 5 induction induction NN cord-005453-4057qib7 13748 6 still still RB cord-005453-4057qib7 13748 7 5 5 CD cord-005453-4057qib7 13748 8 % % NN cord-005453-4057qib7 13748 9 leukemic leukemic JJ cord-005453-4057qib7 13748 10 cells cell NNS cord-005453-4057qib7 13748 11 were be VBD cord-005453-4057qib7 13748 12 detected detect VBN cord-005453-4057qib7 13748 13 in in IN cord-005453-4057qib7 13748 14 bone bone NN cord-005453-4057qib7 13748 15 marrow marrow NN cord-005453-4057qib7 13748 16 , , , cord-005453-4057qib7 13748 17 so so CC cord-005453-4057qib7 13748 18 the the DT cord-005453-4057qib7 13748 19 bispecific bispecific NN cord-005453-4057qib7 13748 20 T t NN cord-005453-4057qib7 13748 21 - - HYPH cord-005453-4057qib7 13748 22 cell cell NN cord-005453-4057qib7 13748 23 engager engager NNP cord-005453-4057qib7 13748 24 antibody antibody NNP cord-005453-4057qib7 13748 25 blinatumomab blinatumomab NNP cord-005453-4057qib7 13748 26 was be VBD cord-005453-4057qib7 13748 27 given give VBN cord-005453-4057qib7 13748 28 . . . cord-005453-4057qib7 13749 1 Due due IN cord-005453-4057qib7 13749 2 to to IN cord-005453-4057qib7 13749 3 an an DT cord-005453-4057qib7 13749 4 increasing increase VBG cord-005453-4057qib7 13749 5 portion portion NN cord-005453-4057qib7 13749 6 of of IN cord-005453-4057qib7 13749 7 leukemic leukemic JJ cord-005453-4057qib7 13749 8 cells cell NNS cord-005453-4057qib7 13749 9 during during IN cord-005453-4057qib7 13749 10 the the DT cord-005453-4057qib7 13749 11 continuous continuous JJ cord-005453-4057qib7 13749 12 infusion infusion NN cord-005453-4057qib7 13749 13 , , , cord-005453-4057qib7 13749 14 antibody antibody NN cord-005453-4057qib7 13749 15 therapy therapy NN cord-005453-4057qib7 13749 16 was be VBD cord-005453-4057qib7 13749 17 stopped stop VBN cord-005453-4057qib7 13749 18 and and CC cord-005453-4057qib7 13749 19 a a DT cord-005453-4057qib7 13749 20 cycle cycle NN cord-005453-4057qib7 13749 21 of of IN cord-005453-4057qib7 13749 22 clofarabine clofarabine NN cord-005453-4057qib7 13749 23 , , , cord-005453-4057qib7 13749 24 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 13749 25 and and CC cord-005453-4057qib7 13749 26 etoposide etoposide NN cord-005453-4057qib7 13749 27 was be VBD cord-005453-4057qib7 13749 28 administered administer VBN cord-005453-4057qib7 13749 29 . . . cord-005453-4057qib7 13750 1 Unfortunately unfortunately RB cord-005453-4057qib7 13750 2 , , , cord-005453-4057qib7 13750 3 still still RB cord-005453-4057qib7 13750 4 31 31 CD cord-005453-4057qib7 13750 5 % % NN cord-005453-4057qib7 13750 6 leukemic leukemic JJ cord-005453-4057qib7 13750 7 cells cell NNS cord-005453-4057qib7 13750 8 were be VBD cord-005453-4057qib7 13750 9 detectable detectable JJ cord-005453-4057qib7 13750 10 afterwards afterwards RB cord-005453-4057qib7 13750 11 . . . cord-005453-4057qib7 13751 1 Because because IN cord-005453-4057qib7 13751 2 of of IN cord-005453-4057qib7 13751 3 chemotherapy chemotherapy NN cord-005453-4057qib7 13751 4 - - HYPH cord-005453-4057qib7 13751 5 refractory refractory JJ cord-005453-4057qib7 13751 6 leukemia leukemia NN cord-005453-4057qib7 13751 7 a a DT cord-005453-4057qib7 13751 8 palliative palliative JJ cord-005453-4057qib7 13751 9 oral oral JJ cord-005453-4057qib7 13751 10 treatment treatment NN cord-005453-4057qib7 13751 11 with with IN cord-005453-4057qib7 13751 12 mercaptopurine mercaptopurine NNP cord-005453-4057qib7 13751 13 was be VBD cord-005453-4057qib7 13751 14 started start VBN cord-005453-4057qib7 13751 15 . . . cord-005453-4057qib7 13752 1 However however RB cord-005453-4057qib7 13752 2 , , , cord-005453-4057qib7 13752 3 the the DT cord-005453-4057qib7 13752 4 parents parent NNS cord-005453-4057qib7 13752 5 did do VBD cord-005453-4057qib7 13752 6 not not RB cord-005453-4057qib7 13752 7 accept accept VB cord-005453-4057qib7 13752 8 the the DT cord-005453-4057qib7 13752 9 palliative palliative JJ cord-005453-4057qib7 13752 10 situation situation NN cord-005453-4057qib7 13752 11 and and CC cord-005453-4057qib7 13752 12 searched search VBD cord-005453-4057qib7 13752 13 for for IN cord-005453-4057qib7 13752 14 alternative alternative JJ cord-005453-4057qib7 13752 15 therapeutic therapeutic JJ cord-005453-4057qib7 13752 16 options option NNS cord-005453-4057qib7 13752 17 in in IN cord-005453-4057qib7 13752 18 other other JJ cord-005453-4057qib7 13752 19 university university NN cord-005453-4057qib7 13752 20 hospitals hospital NNS cord-005453-4057qib7 13752 21 in in IN cord-005453-4057qib7 13752 22 Europe Europe NNP cord-005453-4057qib7 13752 23 . . . cord-005453-4057qib7 13753 1 After after IN cord-005453-4057qib7 13753 2 plenty plenty NN cord-005453-4057qib7 13753 3 of of IN cord-005453-4057qib7 13753 4 refusals refusal NNS cord-005453-4057qib7 13753 5 the the DT cord-005453-4057qib7 13753 6 infant infant NN cord-005453-4057qib7 13753 7 was be VBD cord-005453-4057qib7 13753 8 admitted admit VBN cord-005453-4057qib7 13753 9 to to IN cord-005453-4057qib7 13753 10 our -PRON- PRP$ cord-005453-4057qib7 13753 11 hospital hospital NN cord-005453-4057qib7 13753 12 five five CD cord-005453-4057qib7 13753 13 months month NNS cord-005453-4057qib7 13753 14 after after IN cord-005453-4057qib7 13753 15 diagnosis diagnosis NN cord-005453-4057qib7 13753 16 . . . cord-005453-4057qib7 13754 1 Methods method NNS cord-005453-4057qib7 13754 2 : : : cord-005453-4057qib7 13754 3 For for IN cord-005453-4057qib7 13754 4 molecular molecular JJ cord-005453-4057qib7 13754 5 characterization characterization NN cord-005453-4057qib7 13754 6 genomic genomic JJ cord-005453-4057qib7 13754 7 DNA dna NN cord-005453-4057qib7 13754 8 was be VBD cord-005453-4057qib7 13754 9 isolated isolate VBN cord-005453-4057qib7 13754 10 from from IN cord-005453-4057qib7 13754 11 leukemic leukemic JJ cord-005453-4057qib7 13754 12 cells cell NNS cord-005453-4057qib7 13754 13 . . . cord-005453-4057qib7 13755 1 A a DT cord-005453-4057qib7 13755 2 MLL MLL NNP cord-005453-4057qib7 13755 3 - - HYPH cord-005453-4057qib7 13755 4 MLLT3 MLLT3 NNP cord-005453-4057qib7 13755 5 / / SYM cord-005453-4057qib7 13755 6 AF9 af9 NN cord-005453-4057qib7 13755 7 rearrangement rearrangement NN cord-005453-4057qib7 13755 8 as as IN cord-005453-4057qib7 13755 9 a a DT cord-005453-4057qib7 13755 10 consequence consequence NN cord-005453-4057qib7 13755 11 of of IN cord-005453-4057qib7 13755 12 the the DT cord-005453-4057qib7 13755 13 translocation translocation NN cord-005453-4057qib7 13755 14 t(9;11 t(9;11 NN cord-005453-4057qib7 13755 15 ) ) -RRB- cord-005453-4057qib7 13756 1 ( ( -LRB- cord-005453-4057qib7 13756 2 p22;q23 p22;q23 NNS cord-005453-4057qib7 13756 3 ) ) -RRB- cord-005453-4057qib7 13756 4 was be VBD cord-005453-4057qib7 13756 5 detected detect VBN cord-005453-4057qib7 13756 6 and and CC cord-005453-4057qib7 13756 7 used use VBN cord-005453-4057qib7 13756 8 as as IN cord-005453-4057qib7 13756 9 a a DT cord-005453-4057qib7 13756 10 marker marker NN cord-005453-4057qib7 13756 11 for for IN cord-005453-4057qib7 13756 12 minimal minimal JJ cord-005453-4057qib7 13756 13 residual residual JJ cord-005453-4057qib7 13756 14 disease disease NN cord-005453-4057qib7 13756 15 . . . cord-005453-4057qib7 13757 1 For for IN cord-005453-4057qib7 13757 2 further further JJ cord-005453-4057qib7 13757 3 molecular molecular JJ cord-005453-4057qib7 13757 4 characterization characterization NN cord-005453-4057qib7 13757 5 targeted target VBN cord-005453-4057qib7 13757 6 deep deep JJ cord-005453-4057qib7 13757 7 next next JJ cord-005453-4057qib7 13757 8 - - HYPH cord-005453-4057qib7 13757 9 generation generation NN cord-005453-4057qib7 13757 10 sequencing sequencing NN cord-005453-4057qib7 13757 11 was be VBD cord-005453-4057qib7 13757 12 performed perform VBN cord-005453-4057qib7 13757 13 for for IN cord-005453-4057qib7 13757 14 a a DT cord-005453-4057qib7 13757 15 panel panel NN cord-005453-4057qib7 13757 16 of of IN cord-005453-4057qib7 13757 17 54 54 CD cord-005453-4057qib7 13757 18 leukemia leukemia NN cord-005453-4057qib7 13757 19 - - HYPH cord-005453-4057qib7 13757 20 associated associate VBN cord-005453-4057qib7 13757 21 genes gene NNS cord-005453-4057qib7 13757 22 . . . cord-005453-4057qib7 13758 1 Interestingly interestingly RB cord-005453-4057qib7 13758 2 , , , cord-005453-4057qib7 13758 3 no no DT cord-005453-4057qib7 13758 4 mutation mutation NN cord-005453-4057qib7 13758 5 was be VBD cord-005453-4057qib7 13758 6 found find VBN cord-005453-4057qib7 13758 7 . . . cord-005453-4057qib7 13759 1 To to TO cord-005453-4057qib7 13759 2 allow allow VB cord-005453-4057qib7 13759 3 precise precise JJ cord-005453-4057qib7 13759 4 immunophenotyping immunophenotyping NN cord-005453-4057qib7 13759 5 of of IN cord-005453-4057qib7 13759 6 the the DT cord-005453-4057qib7 13759 7 leukemic leukemic JJ cord-005453-4057qib7 13759 8 cells cell NNS cord-005453-4057qib7 13759 9 treatment treatment NN cord-005453-4057qib7 13759 10 with with IN cord-005453-4057qib7 13759 11 mercaptopurine mercaptopurine NNP cord-005453-4057qib7 13759 12 was be VBD cord-005453-4057qib7 13759 13 stopped stop VBN cord-005453-4057qib7 13759 14 . . . cord-005453-4057qib7 13760 1 Results result NNS cord-005453-4057qib7 13760 2 : : : cord-005453-4057qib7 13761 1 As as IN cord-005453-4057qib7 13761 2 in in IN cord-005453-4057qib7 13761 3 the the DT cord-005453-4057qib7 13761 4 first first JJ cord-005453-4057qib7 13761 5 immunophenotyping immunophenotype VBG cord-005453-4057qib7 13761 6 the the DT cord-005453-4057qib7 13761 7 CD33 CD33 NNP cord-005453-4057qib7 13761 8 antigen antigen NN cord-005453-4057qib7 13761 9 was be VBD cord-005453-4057qib7 13761 10 found find VBN cord-005453-4057qib7 13761 11 , , , cord-005453-4057qib7 13761 12 we -PRON- PRP cord-005453-4057qib7 13761 13 administered administer VBD cord-005453-4057qib7 13761 14 the the DT cord-005453-4057qib7 13761 15 anti anti JJ cord-005453-4057qib7 13761 16 - - JJ cord-005453-4057qib7 13761 17 CD33 CD33 NNP cord-005453-4057qib7 13761 18 monoclonal monoclonal JJ cord-005453-4057qib7 13761 19 antibody antibody NN cord-005453-4057qib7 13761 20 gemtuzumab gemtuzumab VBN cord-005453-4057qib7 13761 21 ozogamicin ozogamicin NNS cord-005453-4057qib7 13761 22 twice twice RB cord-005453-4057qib7 13761 23 within within IN cord-005453-4057qib7 13761 24 two two CD cord-005453-4057qib7 13761 25 weeks week NNS cord-005453-4057qib7 13761 26 . . . cord-005453-4057qib7 13762 1 Because because IN cord-005453-4057qib7 13762 2 of of IN cord-005453-4057qib7 13762 3 the the DT cord-005453-4057qib7 13762 4 detection detection NN cord-005453-4057qib7 13762 5 of of IN cord-005453-4057qib7 13762 6 CD38 CD38 NNP cord-005453-4057qib7 13762 7 + + CC cord-005453-4057qib7 13762 8 leukemic leukemic JJ cord-005453-4057qib7 13762 9 cells cell NNS cord-005453-4057qib7 13762 10 after after IN cord-005453-4057qib7 13762 11 infusion infusion NN cord-005453-4057qib7 13762 12 of of IN cord-005453-4057qib7 13762 13 gemtuzumab gemtuzumab JJ cord-005453-4057qib7 13762 14 ozogamicin ozogamicin NNS cord-005453-4057qib7 13762 15 , , , cord-005453-4057qib7 13762 16 the the DT cord-005453-4057qib7 13762 17 anti anti JJ cord-005453-4057qib7 13762 18 - - JJ cord-005453-4057qib7 13762 19 CD38 cd38 JJ cord-005453-4057qib7 13762 20 antibody antibody NN cord-005453-4057qib7 13762 21 daratumumab daratumumab NNP cord-005453-4057qib7 13762 22 was be VBD cord-005453-4057qib7 13762 23 given give VBN cord-005453-4057qib7 13762 24 alternating alternate VBG cord-005453-4057qib7 13762 25 twice twice RB cord-005453-4057qib7 13762 26 within within IN cord-005453-4057qib7 13762 27 two two CD cord-005453-4057qib7 13762 28 weeks week NNS cord-005453-4057qib7 13762 29 . . . cord-005453-4057qib7 13763 1 Unfortunately unfortunately RB cord-005453-4057qib7 13763 2 afterwards afterwards RB cord-005453-4057qib7 13763 3 , , , cord-005453-4057qib7 13763 4 leukemic leukemic JJ cord-005453-4057qib7 13763 5 cells cell NNS cord-005453-4057qib7 13763 6 reappeared reappear VBD cord-005453-4057qib7 13763 7 being be VBG cord-005453-4057qib7 13763 8 negative negative JJ cord-005453-4057qib7 13763 9 for for IN cord-005453-4057qib7 13763 10 CD33 CD33 NNP cord-005453-4057qib7 13763 11 und und IN cord-005453-4057qib7 13763 12 CD38 CD38 NNP cord-005453-4057qib7 13763 13 , , , cord-005453-4057qib7 13763 14 but but CC cord-005453-4057qib7 13763 15 positive positive JJ cord-005453-4057qib7 13763 16 for for IN cord-005453-4057qib7 13763 17 CD22 CD22 NNP cord-005453-4057qib7 13763 18 . . . cord-005453-4057qib7 13764 1 Therefore therefore RB cord-005453-4057qib7 13764 2 , , , cord-005453-4057qib7 13764 3 we -PRON- PRP cord-005453-4057qib7 13764 4 administered administer VBD cord-005453-4057qib7 13764 5 the the DT cord-005453-4057qib7 13764 6 third third JJ cord-005453-4057qib7 13764 7 antibody antibody NN cord-005453-4057qib7 13764 8 , , , cord-005453-4057qib7 13764 9 the the DT cord-005453-4057qib7 13764 10 anti anti JJ cord-005453-4057qib7 13764 11 - - JJ cord-005453-4057qib7 13764 12 CD22 CD22 NNP cord-005453-4057qib7 13764 13 monoclonal monoclonal JJ cord-005453-4057qib7 13764 14 antibody antibody NN cord-005453-4057qib7 13764 15 inotuzumab inotuzumab NNS cord-005453-4057qib7 13764 16 ozogamicin ozogamicin NNS cord-005453-4057qib7 13764 17 , , , cord-005453-4057qib7 13764 18 whereupon whereupon WRB cord-005453-4057qib7 13764 19 our -PRON- PRP$ cord-005453-4057qib7 13764 20 patient patient NN cord-005453-4057qib7 13764 21 developed develop VBD cord-005453-4057qib7 13764 22 a a DT cord-005453-4057qib7 13764 23 tumor tumor NN cord-005453-4057qib7 13764 24 lysis lysis NN cord-005453-4057qib7 13764 25 syndrome syndrome NN cord-005453-4057qib7 13764 26 and and CC cord-005453-4057qib7 13764 27 a a DT cord-005453-4057qib7 13764 28 severe severe JJ cord-005453-4057qib7 13764 29 bone bone NN cord-005453-4057qib7 13764 30 marrow marrow NN cord-005453-4057qib7 13764 31 aplasia aplasia NNP cord-005453-4057qib7 13764 32 . . . cord-005453-4057qib7 13765 1 Shortly shortly RB cord-005453-4057qib7 13765 2 after after RB cord-005453-4057qib7 13765 3 , , , cord-005453-4057qib7 13765 4 allogeneic allogeneic IN cord-005453-4057qib7 13765 5 bone bone NN cord-005453-4057qib7 13765 6 marrow marrow NN cord-005453-4057qib7 13765 7 transplantation transplantation NN cord-005453-4057qib7 13765 8 from from IN cord-005453-4057qib7 13765 9 an an DT cord-005453-4057qib7 13765 10 unrelated unrelated JJ cord-005453-4057qib7 13765 11 donor donor NN cord-005453-4057qib7 13765 12 using use VBG cord-005453-4057qib7 13765 13 a a DT cord-005453-4057qib7 13765 14 special special JJ cord-005453-4057qib7 13765 15 conditioning conditioning NN cord-005453-4057qib7 13765 16 regimen regimen NN cord-005453-4057qib7 13765 17 consisting consist VBG cord-005453-4057qib7 13765 18 of of IN cord-005453-4057qib7 13765 19 thymoglobulin thymoglobulin NNP cord-005453-4057qib7 13765 20 , , , cord-005453-4057qib7 13765 21 busulfan busulfan NN cord-005453-4057qib7 13765 22 , , , cord-005453-4057qib7 13765 23 fludarabine fludarabine NN cord-005453-4057qib7 13765 24 and and CC cord-005453-4057qib7 13765 25 clofarabine clofarabine NNP cord-005453-4057qib7 13765 26 was be VBD cord-005453-4057qib7 13765 27 conducted conduct VBN cord-005453-4057qib7 13765 28 . . . cord-005453-4057qib7 13766 1 Clofarabine Clofarabine NNP cord-005453-4057qib7 13766 2 was be VBD cord-005453-4057qib7 13766 3 added add VBN cord-005453-4057qib7 13766 4 because because IN cord-005453-4057qib7 13766 5 an an DT cord-005453-4057qib7 13766 6 additional additional JJ cord-005453-4057qib7 13766 7 antileukemic antileukemic JJ cord-005453-4057qib7 13766 8 effect effect NN cord-005453-4057qib7 13766 9 especially especially RB cord-005453-4057qib7 13766 10 in in IN cord-005453-4057qib7 13766 11 infant infant NN cord-005453-4057qib7 13766 12 ALL all DT cord-005453-4057qib7 13766 13 with with IN cord-005453-4057qib7 13766 14 MLL MLL NNP cord-005453-4057qib7 13766 15 rearrangement rearrangement NN cord-005453-4057qib7 13766 16 was be VBD cord-005453-4057qib7 13766 17 described describe VBN cord-005453-4057qib7 13766 18 . . . cord-005453-4057qib7 13767 1 After after IN cord-005453-4057qib7 13767 2 transplantation transplantation NN cord-005453-4057qib7 13767 3 the the DT cord-005453-4057qib7 13767 4 patient patient NN cord-005453-4057qib7 13767 5 suffered suffer VBD cord-005453-4057qib7 13767 6 from from IN cord-005453-4057qib7 13767 7 a a DT cord-005453-4057qib7 13767 8 severe severe JJ cord-005453-4057qib7 13767 9 hepatic hepatic JJ cord-005453-4057qib7 13767 10 sinusoidal sinusoidal JJ cord-005453-4057qib7 13767 11 obstruction obstruction NN cord-005453-4057qib7 13767 12 syndrome syndrome NN cord-005453-4057qib7 13767 13 with with IN cord-005453-4057qib7 13767 14 massive massive JJ cord-005453-4057qib7 13767 15 ascites ascites NN cord-005453-4057qib7 13767 16 , , , cord-005453-4057qib7 13767 17 renal renal JJ cord-005453-4057qib7 13767 18 and and CC cord-005453-4057qib7 13767 19 pulmonary pulmonary JJ cord-005453-4057qib7 13767 20 dysfunction dysfunction NN cord-005453-4057qib7 13767 21 , , , cord-005453-4057qib7 13767 22 but but CC cord-005453-4057qib7 13767 23 finally finally RB cord-005453-4057qib7 13767 24 the the DT cord-005453-4057qib7 13767 25 patient patient NN cord-005453-4057qib7 13767 26 recovered recover VBD cord-005453-4057qib7 13767 27 completely completely RB cord-005453-4057qib7 13767 28 . . . cord-005453-4057qib7 13768 1 The the DT cord-005453-4057qib7 13768 2 first first JJ cord-005453-4057qib7 13768 3 bone bone NN cord-005453-4057qib7 13768 4 marrow marrow NN cord-005453-4057qib7 13768 5 examination examination NN cord-005453-4057qib7 13768 6 30 30 CD cord-005453-4057qib7 13768 7 days day NNS cord-005453-4057qib7 13768 8 after after IN cord-005453-4057qib7 13768 9 transplantation transplantation NN cord-005453-4057qib7 13768 10 revealed reveal VBD cord-005453-4057qib7 13768 11 a a DT cord-005453-4057qib7 13768 12 donor donor NN cord-005453-4057qib7 13768 13 chimerism chimerism NN cord-005453-4057qib7 13768 14 of of IN cord-005453-4057qib7 13768 15 100 100 CD cord-005453-4057qib7 13768 16 % % NN cord-005453-4057qib7 13768 17 and and CC cord-005453-4057qib7 13768 18 a a DT cord-005453-4057qib7 13768 19 complete complete JJ cord-005453-4057qib7 13768 20 molecular molecular JJ cord-005453-4057qib7 13768 21 remission remission NN cord-005453-4057qib7 13768 22 using use VBG cord-005453-4057qib7 13768 23 the the DT cord-005453-4057qib7 13768 24 MLL MLL NNP cord-005453-4057qib7 13768 25 - - HYPH cord-005453-4057qib7 13768 26 MLLT3 MLLT3 NNP cord-005453-4057qib7 13768 27 / / SYM cord-005453-4057qib7 13768 28 AF9 af9 NN cord-005453-4057qib7 13768 29 rearrangement rearrangement NN cord-005453-4057qib7 13768 30 as as IN cord-005453-4057qib7 13768 31 marker marker NN cord-005453-4057qib7 13768 32 for for IN cord-005453-4057qib7 13768 33 minimal minimal JJ cord-005453-4057qib7 13768 34 residual residual JJ cord-005453-4057qib7 13768 35 disease disease NN cord-005453-4057qib7 13768 36 . . . cord-005453-4057qib7 13769 1 In in IN cord-005453-4057qib7 13769 2 all all DT cord-005453-4057qib7 13769 3 follow follow VB cord-005453-4057qib7 13769 4 - - HYPH cord-005453-4057qib7 13769 5 up up RP cord-005453-4057qib7 13769 6 bone bone NN cord-005453-4057qib7 13769 7 marrow marrow NN cord-005453-4057qib7 13769 8 samples sample NNS cord-005453-4057qib7 13769 9 we -PRON- PRP cord-005453-4057qib7 13769 10 observed observe VBD cord-005453-4057qib7 13769 11 a a DT cord-005453-4057qib7 13769 12 complete complete JJ cord-005453-4057qib7 13769 13 donor donor NN cord-005453-4057qib7 13769 14 chimerism chimerism NN cord-005453-4057qib7 13769 15 and and CC cord-005453-4057qib7 13769 16 a a DT cord-005453-4057qib7 13769 17 complete complete JJ cord-005453-4057qib7 13769 18 molecular molecular JJ cord-005453-4057qib7 13769 19 remission remission NN cord-005453-4057qib7 13769 20 . . . cord-005453-4057qib7 13770 1 Currently currently RB cord-005453-4057qib7 13770 2 , , , cord-005453-4057qib7 13770 3 eight eight CD cord-005453-4057qib7 13770 4 months month NNS cord-005453-4057qib7 13770 5 after after IN cord-005453-4057qib7 13770 6 transplantation transplantation NN cord-005453-4057qib7 13770 7 the the DT cord-005453-4057qib7 13770 8 patient patient NN cord-005453-4057qib7 13770 9 is be VBZ cord-005453-4057qib7 13770 10 in in IN cord-005453-4057qib7 13770 11 a a DT cord-005453-4057qib7 13770 12 very very RB cord-005453-4057qib7 13770 13 good good JJ cord-005453-4057qib7 13770 14 physical physical JJ cord-005453-4057qib7 13770 15 condition condition NN cord-005453-4057qib7 13770 16 with with IN cord-005453-4057qib7 13770 17 normal normal JJ cord-005453-4057qib7 13770 18 development development NN cord-005453-4057qib7 13770 19 according accord VBG cord-005453-4057qib7 13770 20 to to IN cord-005453-4057qib7 13770 21 the the DT cord-005453-4057qib7 13770 22 age age NN cord-005453-4057qib7 13770 23 . . . cord-005453-4057qib7 13771 1 Background background NN cord-005453-4057qib7 13771 2 : : : cord-005453-4057qib7 13772 1 Paediatric paediatric JJ cord-005453-4057qib7 13772 2 chronic chronic JJ cord-005453-4057qib7 13772 3 graft graft NN cord-005453-4057qib7 13772 4 versus versus IN cord-005453-4057qib7 13772 5 host host NN cord-005453-4057qib7 13772 6 disease disease NN cord-005453-4057qib7 13772 7 ( ( -LRB- cord-005453-4057qib7 13772 8 cGVHD cGVHD NNP cord-005453-4057qib7 13772 9 ) ) -RRB- cord-005453-4057qib7 13772 10 is be VBZ cord-005453-4057qib7 13772 11 a a DT cord-005453-4057qib7 13772 12 debilitating debilitating JJ cord-005453-4057qib7 13772 13 condition condition NN cord-005453-4057qib7 13772 14 associated associate VBN cord-005453-4057qib7 13772 15 with with IN cord-005453-4057qib7 13772 16 substantial substantial JJ cord-005453-4057qib7 13772 17 morbidity morbidity NN cord-005453-4057qib7 13772 18 and and CC cord-005453-4057qib7 13772 19 mortality mortality NN cord-005453-4057qib7 13772 20 . . . cord-005453-4057qib7 13773 1 To to IN cord-005453-4057qib7 13773 2 date date NN cord-005453-4057qib7 13773 3 , , , cord-005453-4057qib7 13773 4 there there EX cord-005453-4057qib7 13773 5 are be VBP cord-005453-4057qib7 13773 6 no no DT cord-005453-4057qib7 13773 7 approved approve VBN cord-005453-4057qib7 13773 8 therapies therapy NNS cord-005453-4057qib7 13773 9 for for IN cord-005453-4057qib7 13773 10 paediatric paediatric JJ cord-005453-4057qib7 13773 11 patients patient NNS cord-005453-4057qib7 13773 12 with with IN cord-005453-4057qib7 13773 13 cGVHD cGVHD NNP cord-005453-4057qib7 13773 14 , , , cord-005453-4057qib7 13773 15 and and CC cord-005453-4057qib7 13773 16 current current JJ cord-005453-4057qib7 13773 17 treatments treatment NNS cord-005453-4057qib7 13773 18 often often RB cord-005453-4057qib7 13773 19 lack lack VBP cord-005453-4057qib7 13773 20 sufficient sufficient JJ cord-005453-4057qib7 13773 21 efficacy efficacy NN cord-005453-4057qib7 13773 22 or or CC cord-005453-4057qib7 13773 23 lead lead NN cord-005453-4057qib7 13773 24 to to IN cord-005453-4057qib7 13773 25 severe severe JJ cord-005453-4057qib7 13773 26 / / SYM cord-005453-4057qib7 13773 27 life life NN cord-005453-4057qib7 13773 28 - - HYPH cord-005453-4057qib7 13773 29 threatening threaten VBG cord-005453-4057qib7 13773 30 toxicities toxicity NNS cord-005453-4057qib7 13773 31 that that WDT cord-005453-4057qib7 13773 32 limit limit VBP cord-005453-4057qib7 13773 33 their -PRON- PRP$ cord-005453-4057qib7 13773 34 effectiveness effectiveness NN cord-005453-4057qib7 13773 35 . . . cord-005453-4057qib7 13774 1 Ibrutinib Ibrutinib NNP cord-005453-4057qib7 13774 2 , , , cord-005453-4057qib7 13774 3 a a DT cord-005453-4057qib7 13774 4 first first JJ cord-005453-4057qib7 13774 5 - - HYPH cord-005453-4057qib7 13774 6 in in IN cord-005453-4057qib7 13774 7 - - HYPH cord-005453-4057qib7 13774 8 class class NN cord-005453-4057qib7 13774 9 , , , cord-005453-4057qib7 13774 10 once once RB cord-005453-4057qib7 13774 11 - - HYPH cord-005453-4057qib7 13774 12 daily daily JJ cord-005453-4057qib7 13774 13 inhibitor inhibitor NN cord-005453-4057qib7 13774 14 of of IN cord-005453-4057qib7 13774 15 Bruton Bruton NNP cord-005453-4057qib7 13774 16 's 's POS cord-005453-4057qib7 13774 17 tyrosine tyrosine NN cord-005453-4057qib7 13774 18 kinase kinase NN cord-005453-4057qib7 13774 19 ( ( -LRB- cord-005453-4057qib7 13774 20 BTK BTK NNP cord-005453-4057qib7 13774 21 ) ) -RRB- cord-005453-4057qib7 13774 22 , , , cord-005453-4057qib7 13774 23 is be VBZ cord-005453-4057qib7 13774 24 approved approve VBN cord-005453-4057qib7 13774 25 in in IN cord-005453-4057qib7 13774 26 the the DT cord-005453-4057qib7 13774 27 US US NNP cord-005453-4057qib7 13774 28 for for IN cord-005453-4057qib7 13774 29 the the DT cord-005453-4057qib7 13774 30 treatment treatment NN cord-005453-4057qib7 13774 31 of of IN cord-005453-4057qib7 13774 32 adult adult NN cord-005453-4057qib7 13774 33 patients patient NNS cord-005453-4057qib7 13774 34 with with IN cord-005453-4057qib7 13774 35 cGVHD cGVHD NNP cord-005453-4057qib7 13774 36 after after IN cord-005453-4057qib7 13774 37 failure failure NN cord-005453-4057qib7 13774 38 of of IN cord-005453-4057qib7 13774 39 ≥1 ≥1 NNP cord-005453-4057qib7 13774 40 lines line NNS cord-005453-4057qib7 13774 41 of of IN cord-005453-4057qib7 13774 42 systemic systemic JJ cord-005453-4057qib7 13774 43 therapy therapy NN cord-005453-4057qib7 13774 44 . . . cord-005453-4057qib7 13775 1 This this DT cord-005453-4057qib7 13775 2 phase phase NN cord-005453-4057qib7 13775 3 1/2 1/2 CD cord-005453-4057qib7 13775 4 study study NN cord-005453-4057qib7 13775 5 will will MD cord-005453-4057qib7 13775 6 evaluate evaluate VB cord-005453-4057qib7 13775 7 the the DT cord-005453-4057qib7 13775 8 use use NN cord-005453-4057qib7 13775 9 of of IN cord-005453-4057qib7 13775 10 ibrutinib ibrutinib NN cord-005453-4057qib7 13775 11 in in IN cord-005453-4057qib7 13775 12 paediatric paediatric JJ cord-005453-4057qib7 13775 13 patients patient NNS cord-005453-4057qib7 13775 14 with with IN cord-005453-4057qib7 13775 15 moderate moderate JJ cord-005453-4057qib7 13775 16 or or CC cord-005453-4057qib7 13775 17 severe severe JJ cord-005453-4057qib7 13775 18 cGVHD cgvhd NN cord-005453-4057qib7 13775 19 . . . cord-005453-4057qib7 13776 1 Methods method NNS cord-005453-4057qib7 13776 2 : : : cord-005453-4057qib7 13777 1 This this DT cord-005453-4057qib7 13777 2 open open JJ cord-005453-4057qib7 13777 3 - - HYPH cord-005453-4057qib7 13777 4 label label NN cord-005453-4057qib7 13777 5 , , , cord-005453-4057qib7 13777 6 multicenter multicenter JJ cord-005453-4057qib7 13777 7 , , , cord-005453-4057qib7 13777 8 international international JJ cord-005453-4057qib7 13777 9 phase phase NN cord-005453-4057qib7 13777 10 1/2 1/2 CD cord-005453-4057qib7 13777 11 study study NN cord-005453-4057qib7 13777 12 ( ( -LRB- cord-005453-4057qib7 13777 13 PCYC-1146 PCYC-1146 NNP cord-005453-4057qib7 13777 14 ) ) -RRB- cord-005453-4057qib7 13777 15 includes include VBZ cord-005453-4057qib7 13777 16 patients patient NNS cord-005453-4057qib7 13777 17 with with IN cord-005453-4057qib7 13777 18 moderate moderate JJ cord-005453-4057qib7 13777 19 or or CC cord-005453-4057qib7 13777 20 severe severe JJ cord-005453-4057qib7 13777 21 cGVHD cgvhd NN cord-005453-4057qib7 13777 22 as as IN cord-005453-4057qib7 13777 23 defined define VBN cord-005453-4057qib7 13777 24 by by IN cord-005453-4057qib7 13777 25 the the DT cord-005453-4057qib7 13777 26 2014 2014 CD cord-005453-4057qib7 13777 27 NIH NIH NNP cord-005453-4057qib7 13777 28 Consensus Consensus NNP cord-005453-4057qib7 13777 29 Development Development NNP cord-005453-4057qib7 13777 30 Project Project NNP cord-005453-4057qib7 13777 31 Criteria Criteria NNPS cord-005453-4057qib7 13777 32 . . . cord-005453-4057qib7 13778 1 It -PRON- PRP cord-005453-4057qib7 13778 2 is be VBZ cord-005453-4057qib7 13778 3 divided divide VBN cord-005453-4057qib7 13778 4 into into IN cord-005453-4057qib7 13778 5 two two CD cord-005453-4057qib7 13778 6 parts part NNS cord-005453-4057qib7 13778 7 : : : cord-005453-4057qib7 13778 8 Part Part NNP cord-005453-4057qib7 13778 9 A A NNP cord-005453-4057qib7 13778 10 will will MD cord-005453-4057qib7 13778 11 determine determine VB cord-005453-4057qib7 13778 12 the the DT cord-005453-4057qib7 13778 13 recommended recommend VBN cord-005453-4057qib7 13778 14 paediatric paediatric JJ cord-005453-4057qib7 13778 15 equivalent equivalent JJ cord-005453-4057qib7 13778 16 dose dose NN cord-005453-4057qib7 13778 17 ( ( -LRB- cord-005453-4057qib7 13778 18 RPED RPED NNP cord-005453-4057qib7 13778 19 ) ) -RRB- cord-005453-4057qib7 13778 20 of of IN cord-005453-4057qib7 13778 21 ibrutinib ibrutinib NN cord-005453-4057qib7 13778 22 in in IN cord-005453-4057qib7 13778 23 patients patient NNS cord-005453-4057qib7 13778 24 aged age VBN cord-005453-4057qib7 13778 25 ≥1 ≥1 NN cord-005453-4057qib7 13778 26 to to IN cord-005453-4057qib7 13778 27 < < XX cord-005453-4057qib7 13778 28 12 12 CD cord-005453-4057qib7 13778 29 years year NNS cord-005453-4057qib7 13778 30 , , , cord-005453-4057qib7 13778 31 and and CC cord-005453-4057qib7 13778 32 Part Part NNP cord-005453-4057qib7 13778 33 B B NNP cord-005453-4057qib7 13778 34 aims aim VBZ cord-005453-4057qib7 13778 35 to to TO cord-005453-4057qib7 13778 36 evaluate evaluate VB cord-005453-4057qib7 13778 37 the the DT cord-005453-4057qib7 13778 38 safety safety NN cord-005453-4057qib7 13778 39 and and CC cord-005453-4057qib7 13778 40 efficacy efficacy NN cord-005453-4057qib7 13778 41 of of IN cord-005453-4057qib7 13778 42 ibrutinib ibrutinib NN cord-005453-4057qib7 13778 43 in in IN cord-005453-4057qib7 13778 44 patients patient NNS cord-005453-4057qib7 13778 45 age age NN cord-005453-4057qib7 13778 46 ≥1 ≥1 NN cord-005453-4057qib7 13778 47 to to IN cord-005453-4057qib7 13778 48 < < XX cord-005453-4057qib7 13778 49 22 22 CD cord-005453-4057qib7 13778 50 years year NNS cord-005453-4057qib7 13778 51 . . . cord-005453-4057qib7 13779 1 For for IN cord-005453-4057qib7 13779 2 Part Part NNP cord-005453-4057qib7 13779 3 A A NNP cord-005453-4057qib7 13779 4 , , , cord-005453-4057qib7 13779 5 patients patient NNS cord-005453-4057qib7 13779 6 with with IN cord-005453-4057qib7 13779 7 cGVHD cGVHD NNP cord-005453-4057qib7 13779 8 aged age VBN cord-005453-4057qib7 13779 9 ≥1 ≥1 NNP cord-005453-4057qib7 13779 10 to to IN cord-005453-4057qib7 13779 11 < < XX cord-005453-4057qib7 13779 12 12 12 CD cord-005453-4057qib7 13779 13 years year NNS cord-005453-4057qib7 13779 14 who who WP cord-005453-4057qib7 13779 15 have have VBP cord-005453-4057qib7 13779 16 failed fail VBN cord-005453-4057qib7 13779 17 ≥1 ≥1 JJR cord-005453-4057qib7 13779 18 lines line NNS cord-005453-4057qib7 13779 19 of of IN cord-005453-4057qib7 13779 20 systemic systemic JJ cord-005453-4057qib7 13779 21 therapy therapy NN cord-005453-4057qib7 13779 22 will will MD cord-005453-4057qib7 13779 23 receive receive VB cord-005453-4057qib7 13779 24 once once RB cord-005453-4057qib7 13779 25 daily daily JJ cord-005453-4057qib7 13779 26 oral oral JJ cord-005453-4057qib7 13779 27 ibrutinib ibrutinib NN cord-005453-4057qib7 13779 28 at at IN cord-005453-4057qib7 13779 29 a a DT cord-005453-4057qib7 13779 30 starting starting NN cord-005453-4057qib7 13779 31 dose dose NN cord-005453-4057qib7 13779 32 of of IN cord-005453-4057qib7 13779 33 120 120 CD cord-005453-4057qib7 13779 34 mg mg NNP cord-005453-4057qib7 13779 35 / / SYM cord-005453-4057qib7 13779 36 m m NN cord-005453-4057qib7 13779 37 2 2 CD cord-005453-4057qib7 13779 38 to to TO cord-005453-4057qib7 13779 39 be be VB cord-005453-4057qib7 13779 40 escalated escalate VBN cord-005453-4057qib7 13780 1 up up IN cord-005453-4057qib7 13780 2 to to TO cord-005453-4057qib7 13780 3 240 240 CD cord-005453-4057qib7 13780 4 mg mg NNP cord-005453-4057qib7 13780 5 / / SYM cord-005453-4057qib7 13780 6 m m NN cord-005453-4057qib7 13780 7 2 2 CD cord-005453-4057qib7 13780 8 after after IN cord-005453-4057qib7 13780 9 14 14 CD cord-005453-4057qib7 13780 10 days day NNS cord-005453-4057qib7 13780 11 , , , cord-005453-4057qib7 13780 12 if if IN cord-005453-4057qib7 13780 13 no no DT cord-005453-4057qib7 13780 14 grade grade NN cord-005453-4057qib7 13780 15 ≥3 ≥3 NNP cord-005453-4057qib7 13780 16 toxicities toxicity NNS cord-005453-4057qib7 13780 17 occur occur VBP cord-005453-4057qib7 13780 18 , , , cord-005453-4057qib7 13780 19 until until IN cord-005453-4057qib7 13780 20 the the DT cord-005453-4057qib7 13780 21 RPED RPED NNP cord-005453-4057qib7 13780 22 is be VBZ cord-005453-4057qib7 13780 23 determined determine VBN cord-005453-4057qib7 13780 24 . . . cord-005453-4057qib7 13781 1 For for IN cord-005453-4057qib7 13781 2 Part Part NNP cord-005453-4057qib7 13781 3 B B NNP cord-005453-4057qib7 13781 4 , , , cord-005453-4057qib7 13781 5 patients patient NNS cord-005453-4057qib7 13781 6 aged age VBN cord-005453-4057qib7 13781 7 ≥12 ≥12 NNP cord-005453-4057qib7 13781 8 to to IN cord-005453-4057qib7 13781 9 < < XX cord-005453-4057qib7 13781 10 22 22 CD cord-005453-4057qib7 13781 11 years year NNS cord-005453-4057qib7 13781 12 with with IN cord-005453-4057qib7 13781 13 cGVHD cGVHD NNP cord-005453-4057qib7 13781 14 who who WP cord-005453-4057qib7 13781 15 have have VBP cord-005453-4057qib7 13781 16 failed fail VBN cord-005453-4057qib7 13781 17 ≥1 ≥1 JJR cord-005453-4057qib7 13781 18 lines line NNS cord-005453-4057qib7 13781 19 of of IN cord-005453-4057qib7 13781 20 systemic systemic JJ cord-005453-4057qib7 13781 21 therapy therapy NN cord-005453-4057qib7 13781 22 or or CC cord-005453-4057qib7 13781 23 have have VBP cord-005453-4057qib7 13781 24 newly newly RB cord-005453-4057qib7 13781 25 diagnosed diagnose VBN cord-005453-4057qib7 13781 26 cGVHD cgvhd NN cord-005453-4057qib7 13781 27 will will MD cord-005453-4057qib7 13781 28 receive receive VB cord-005453-4057qib7 13781 29 once once RB cord-005453-4057qib7 13781 30 daily daily JJ cord-005453-4057qib7 13781 31 ibrutinib ibrutinib NN cord-005453-4057qib7 13781 32 ( ( -LRB- cord-005453-4057qib7 13781 33 420 420 CD cord-005453-4057qib7 13781 34 mg mg NNP cord-005453-4057qib7 13781 35 ) ) -RRB- cord-005453-4057qib7 13781 36 until until IN cord-005453-4057qib7 13781 37 one one CD cord-005453-4057qib7 13781 38 of of IN cord-005453-4057qib7 13781 39 the the DT cord-005453-4057qib7 13781 40 following follow VBG cord-005453-4057qib7 13781 41 criteria criterion NNS cord-005453-4057qib7 13781 42 is be VBZ cord-005453-4057qib7 13781 43 met meet VBN cord-005453-4057qib7 13781 44 : : : cord-005453-4057qib7 13782 1 treatment treatment NN cord-005453-4057qib7 13782 2 is be VBZ cord-005453-4057qib7 13782 3 no no DT cord-005453-4057qib7 13782 4 longer long RBR cord-005453-4057qib7 13782 5 required require VBN cord-005453-4057qib7 13782 6 ; ; : cord-005453-4057qib7 13782 7 new new JJ cord-005453-4057qib7 13782 8 systemic systemic JJ cord-005453-4057qib7 13782 9 treatment treatment NN cord-005453-4057qib7 13782 10 for for IN cord-005453-4057qib7 13782 11 cGVHD cGVHD NNP cord-005453-4057qib7 13782 12 is be VBZ cord-005453-4057qib7 13782 13 initiated initiate VBN cord-005453-4057qib7 13782 14 ; ; : cord-005453-4057qib7 13782 15 progression progression NN cord-005453-4057qib7 13782 16 of of IN cord-005453-4057qib7 13782 17 cGVHD cgvhd NN cord-005453-4057qib7 13782 18 ; ; : cord-005453-4057qib7 13782 19 recurrence recurrence NN cord-005453-4057qib7 13782 20 of of IN cord-005453-4057qib7 13782 21 underlying underlie VBG cord-005453-4057qib7 13782 22 disease disease NN cord-005453-4057qib7 13782 23 ; ; : cord-005453-4057qib7 13782 24 or or CC cord-005453-4057qib7 13782 25 unacceptable unacceptable JJ cord-005453-4057qib7 13782 26 toxicity toxicity NN cord-005453-4057qib7 13782 27 . . . cord-005453-4057qib7 13783 1 Patients patient NNS cord-005453-4057qib7 13783 2 with with IN cord-005453-4057qib7 13783 3 newly newly RB cord-005453-4057qib7 13783 4 diagnosed diagnose VBN cord-005453-4057qib7 13783 5 cGVHD cGVHD NNP cord-005453-4057qib7 13783 6 will will MD cord-005453-4057qib7 13783 7 receive receive VB cord-005453-4057qib7 13783 8 ibrutinib ibrutinib NN cord-005453-4057qib7 13783 9 in in IN cord-005453-4057qib7 13783 10 addition addition NN cord-005453-4057qib7 13783 11 to to IN cord-005453-4057qib7 13783 12 daily daily JJ cord-005453-4057qib7 13783 13 corticosteroids corticosteroid NNS cord-005453-4057qib7 13783 14 ( ( -LRB- cord-005453-4057qib7 13783 15 0.5 0.5 CD cord-005453-4057qib7 13783 16 - - SYM cord-005453-4057qib7 13783 17 1 1 CD cord-005453-4057qib7 13783 18 mg mg NNP cord-005453-4057qib7 13783 19 / / SYM cord-005453-4057qib7 13783 20 kg kg NNP cord-005453-4057qib7 13783 21 prednisone prednisone NNP cord-005453-4057qib7 13783 22 ) ) -RRB- cord-005453-4057qib7 13783 23 . . . cord-005453-4057qib7 13784 1 Patients patient NNS cord-005453-4057qib7 13784 2 < < XX cord-005453-4057qib7 13785 1 12 12 CD cord-005453-4057qib7 13785 2 years year NNS cord-005453-4057qib7 13785 3 of of IN cord-005453-4057qib7 13785 4 age age NN cord-005453-4057qib7 13785 5 may may MD cord-005453-4057qib7 13785 6 be be VB cord-005453-4057qib7 13785 7 enrolled enrol VBN cord-005453-4057qib7 13785 8 in in IN cord-005453-4057qib7 13785 9 Part Part NNP cord-005453-4057qib7 13785 10 B B NNP cord-005453-4057qib7 13785 11 and and CC cord-005453-4057qib7 13785 12 treated treat VBN cord-005453-4057qib7 13785 13 at at IN cord-005453-4057qib7 13785 14 the the DT cord-005453-4057qib7 13785 15 RPED RPED NNP cord-005453-4057qib7 13785 16 after after IN cord-005453-4057qib7 13785 17 it -PRON- PRP cord-005453-4057qib7 13785 18 is be VBZ cord-005453-4057qib7 13785 19 determined determine VBN cord-005453-4057qib7 13785 20 in in IN cord-005453-4057qib7 13786 1 Part part NN cord-005453-4057qib7 13786 2 A. a. NN cord-005453-4057qib7 13786 3 Key key JJ cord-005453-4057qib7 13786 4 exclusion exclusion NN cord-005453-4057qib7 13786 5 criteria criterion NNS cord-005453-4057qib7 13786 6 include include VBP cord-005453-4057qib7 13786 7 uncontrolled uncontrolled JJ cord-005453-4057qib7 13786 8 active active JJ cord-005453-4057qib7 13786 9 systemic systemic JJ cord-005453-4057qib7 13786 10 infection infection NN cord-005453-4057qib7 13786 11 or or CC cord-005453-4057qib7 13786 12 active active JJ cord-005453-4057qib7 13786 13 infection infection NN cord-005453-4057qib7 13786 14 requiring require VBG cord-005453-4057qib7 13786 15 systemic systemic JJ cord-005453-4057qib7 13786 16 treatment treatment NN cord-005453-4057qib7 13786 17 ; ; : cord-005453-4057qib7 13786 18 progressive progressive JJ cord-005453-4057qib7 13786 19 underlying underlying JJ cord-005453-4057qib7 13786 20 malignant malignant JJ cord-005453-4057qib7 13786 21 disease disease NN cord-005453-4057qib7 13786 22 or or CC cord-005453-4057qib7 13786 23 any any DT cord-005453-4057qib7 13786 24 post post JJ cord-005453-4057qib7 13786 25 - - JJ cord-005453-4057qib7 13786 26 transplant transplant JJ cord-005453-4057qib7 13786 27 lymphoproliferative lymphoproliferative JJ cord-005453-4057qib7 13786 28 disease disease NN cord-005453-4057qib7 13786 29 ; ; : cord-005453-4057qib7 13786 30 or or CC cord-005453-4057qib7 13786 31 active active JJ cord-005453-4057qib7 13786 32 hepatitis hepatitis NN cord-005453-4057qib7 13786 33 C C NNP cord-005453-4057qib7 13786 34 / / SYM cord-005453-4057qib7 13786 35 hepatitis hepatitis NN cord-005453-4057qib7 13786 36 B B NNP cord-005453-4057qib7 13786 37 virus virus NN cord-005453-4057qib7 13786 38 . . . cord-005453-4057qib7 13787 1 Patients patient NNS cord-005453-4057qib7 13787 2 must must MD cord-005453-4057qib7 13787 3 have have VB cord-005453-4057qib7 13787 4 adequate adequate JJ cord-005453-4057qib7 13787 5 renal renal JJ cord-005453-4057qib7 13787 6 , , , cord-005453-4057qib7 13787 7 hepatic hepatic JJ cord-005453-4057qib7 13787 8 , , , cord-005453-4057qib7 13787 9 and and CC cord-005453-4057qib7 13787 10 hematologic hematologic JJ cord-005453-4057qib7 13787 11 function function NN cord-005453-4057qib7 13787 12 to to TO cord-005453-4057qib7 13787 13 be be VB cord-005453-4057qib7 13787 14 enrolled enrol VBN cord-005453-4057qib7 13787 15 . . . cord-005453-4057qib7 13788 1 The the DT cord-005453-4057qib7 13788 2 primary primary JJ cord-005453-4057qib7 13788 3 endpoint endpoint NN cord-005453-4057qib7 13788 4 of of IN cord-005453-4057qib7 13788 5 Part Part NNP cord-005453-4057qib7 13788 6 A A NNP cord-005453-4057qib7 13788 7 is be VBZ cord-005453-4057qib7 13788 8 the the DT cord-005453-4057qib7 13788 9 RPED RPED NNP cord-005453-4057qib7 13788 10 of of IN cord-005453-4057qib7 13788 11 ibrutinib ibrutinib NN cord-005453-4057qib7 13788 12 , , , cord-005453-4057qib7 13788 13 as as IN cord-005453-4057qib7 13788 14 based base VBN cord-005453-4057qib7 13788 15 on on IN cord-005453-4057qib7 13788 16 pharmacokinetic pharmacokinetic JJ cord-005453-4057qib7 13788 17 ( ( -LRB- cord-005453-4057qib7 13788 18 PK PK NNP cord-005453-4057qib7 13788 19 ) ) -RRB- cord-005453-4057qib7 13788 20 data datum NNS cord-005453-4057qib7 13788 21 ; ; , cord-005453-4057qib7 13788 22 secondary secondary JJ cord-005453-4057qib7 13788 23 endpoints endpoint NNS cord-005453-4057qib7 13788 24 include include VBP cord-005453-4057qib7 13788 25 safety safety NN cord-005453-4057qib7 13788 26 and and CC cord-005453-4057qib7 13788 27 pharmacodynamics pharmacodynamic NNS cord-005453-4057qib7 13788 28 ( ( -LRB- cord-005453-4057qib7 13788 29 BTK BTK NNP cord-005453-4057qib7 13788 30 occupancy occupancy NN cord-005453-4057qib7 13788 31 ) ) -RRB- cord-005453-4057qib7 13788 32 . . . cord-005453-4057qib7 13789 1 The the DT cord-005453-4057qib7 13789 2 primary primary JJ cord-005453-4057qib7 13789 3 endpoints endpoint NNS cord-005453-4057qib7 13789 4 of of IN cord-005453-4057qib7 13789 5 Part Part NNP cord-005453-4057qib7 13789 6 B B NNP cord-005453-4057qib7 13789 7 are be VBP cord-005453-4057qib7 13789 8 PK PK NNP cord-005453-4057qib7 13789 9 and and CC cord-005453-4057qib7 13789 10 safety safety NN cord-005453-4057qib7 13789 11 of of IN cord-005453-4057qib7 13789 12 ibrutinib ibrutinib NN cord-005453-4057qib7 13789 13 in in IN cord-005453-4057qib7 13789 14 paediatric paediatric JJ cord-005453-4057qib7 13789 15 patients patient NNS cord-005453-4057qib7 13789 16 with with IN cord-005453-4057qib7 13789 17 cGVHD cGVHD NNP cord-005453-4057qib7 13789 18 . . . cord-005453-4057qib7 13790 1 Secondary secondary JJ cord-005453-4057qib7 13790 2 endpoints endpoint NNS cord-005453-4057qib7 13790 3 for for IN cord-005453-4057qib7 13790 4 Part Part NNP cord-005453-4057qib7 13790 5 B B NNP cord-005453-4057qib7 13790 6 include include VB cord-005453-4057qib7 13790 7 response response NN cord-005453-4057qib7 13790 8 rate rate NN cord-005453-4057qib7 13790 9 at at IN cord-005453-4057qib7 13790 10 24 24 CD cord-005453-4057qib7 13790 11 weeks week NNS cord-005453-4057qib7 13790 12 as as IN cord-005453-4057qib7 13790 13 defined define VBN cord-005453-4057qib7 13790 14 by by IN cord-005453-4057qib7 13790 15 the the DT cord-005453-4057qib7 13790 16 2014 2014 CD cord-005453-4057qib7 13790 17 NIH NIH NNP cord-005453-4057qib7 13790 18 Consensus Consensus NNP cord-005453-4057qib7 13790 19 Development Development NNP cord-005453-4057qib7 13790 20 Project Project NNP cord-005453-4057qib7 13790 21 Criteria criterion NNS cord-005453-4057qib7 13790 22 ; ; : cord-005453-4057qib7 13790 23 duration duration NN cord-005453-4057qib7 13790 24 of of IN cord-005453-4057qib7 13790 25 response response NN cord-005453-4057qib7 13790 26 ; ; : cord-005453-4057qib7 13790 27 overall overall JJ cord-005453-4057qib7 13790 28 survival survival NN cord-005453-4057qib7 13790 29 ; ; : cord-005453-4057qib7 13790 30 and and CC cord-005453-4057qib7 13790 31 late late JJ cord-005453-4057qib7 13790 32 effects effect NNS cord-005453-4057qib7 13790 33 on on IN cord-005453-4057qib7 13790 34 growth growth NN cord-005453-4057qib7 13790 35 , , , cord-005453-4057qib7 13790 36 development development NN cord-005453-4057qib7 13790 37 , , , cord-005453-4057qib7 13790 38 and and CC cord-005453-4057qib7 13790 39 immune immune JJ cord-005453-4057qib7 13790 40 reconstitution reconstitution NN cord-005453-4057qib7 13790 41 . . . cord-005453-4057qib7 13791 1 Results result NNS cord-005453-4057qib7 13791 2 : : : cord-005453-4057qib7 13792 1 This this DT cord-005453-4057qib7 13792 2 global global JJ cord-005453-4057qib7 13792 3 study study NN cord-005453-4057qib7 13792 4 is be VBZ cord-005453-4057qib7 13792 5 currently currently RB cord-005453-4057qib7 13792 6 enrolling enrol VBG cord-005453-4057qib7 13792 7 . . . cord-005453-4057qib7 13793 1 Conclusions conclusion NNS cord-005453-4057qib7 13793 2 : : : cord-005453-4057qib7 13794 1 This this DT cord-005453-4057qib7 13794 2 phase phase NN cord-005453-4057qib7 13794 3 1/2 1/2 CD cord-005453-4057qib7 13794 4 study study NN cord-005453-4057qib7 13794 5 will will MD cord-005453-4057qib7 13794 6 explore explore VB cord-005453-4057qib7 13794 7 the the DT cord-005453-4057qib7 13794 8 use use NN cord-005453-4057qib7 13794 9 of of IN cord-005453-4057qib7 13794 10 ibrutinib ibrutinib NN cord-005453-4057qib7 13794 11 in in IN cord-005453-4057qib7 13794 12 paediatric paediatric JJ cord-005453-4057qib7 13794 13 patients patient NNS cord-005453-4057qib7 13794 14 with with IN cord-005453-4057qib7 13794 15 cGVHD cGVHD NNP cord-005453-4057qib7 13794 16 to to TO cord-005453-4057qib7 13794 17 potentially potentially RB cord-005453-4057qib7 13794 18 meet meet VB cord-005453-4057qib7 13794 19 the the DT cord-005453-4057qib7 13794 20 high high JJ cord-005453-4057qib7 13794 21 unmet unmet JJ cord-005453-4057qib7 13794 22 need need NN cord-005453-4057qib7 13794 23 for for IN cord-005453-4057qib7 13794 24 proven prove VBN cord-005453-4057qib7 13794 25 effective effective JJ cord-005453-4057qib7 13794 26 therapies therapy NNS cord-005453-4057qib7 13794 27 for for IN cord-005453-4057qib7 13794 28 this this DT cord-005453-4057qib7 13794 29 population population NN cord-005453-4057qib7 13794 30 . . . cord-005453-4057qib7 13795 1 Disclosure disclosure NN cord-005453-4057qib7 13795 2 Enzyme Enzyme NNP cord-005453-4057qib7 13795 3 Replacement Replacement NNP cord-005453-4057qib7 13795 4 Therapy therapy NN cord-005453-4057qib7 13795 5 ( ( -LRB- cord-005453-4057qib7 13795 6 ERT ERT NNP cord-005453-4057qib7 13795 7 ) ) -RRB- cord-005453-4057qib7 13795 8 is be VBZ cord-005453-4057qib7 13795 9 the the DT cord-005453-4057qib7 13795 10 treatment treatment NN cord-005453-4057qib7 13795 11 of of IN cord-005453-4057qib7 13795 12 choice choice NN cord-005453-4057qib7 13795 13 in in IN cord-005453-4057qib7 13795 14 non non JJ cord-005453-4057qib7 13795 15 - - JJ cord-005453-4057qib7 13795 16 neuropathic neuropathic JJ cord-005453-4057qib7 13795 17 Hunter Hunter NNP cord-005453-4057qib7 13795 18 syndrome syndrome NN cord-005453-4057qib7 13795 19 , , , cord-005453-4057qib7 13795 20 but but CC cord-005453-4057qib7 13795 21 as as IN cord-005453-4057qib7 13795 22 the the DT cord-005453-4057qib7 13795 23 recombinant recombinant JJ cord-005453-4057qib7 13795 24 enzyme enzyme NN cord-005453-4057qib7 13795 25 does do VBZ cord-005453-4057qib7 13795 26 not not RB cord-005453-4057qib7 13795 27 cross cross VB cord-005453-4057qib7 13795 28 the the DT cord-005453-4057qib7 13795 29 blood blood NN cord-005453-4057qib7 13795 30 brain brain NN cord-005453-4057qib7 13795 31 barrier barrier NN cord-005453-4057qib7 13795 32 and and CC cord-005453-4057qib7 13795 33 neuropathic neuropathic JJ cord-005453-4057qib7 13795 34 Hunter Hunter NNP cord-005453-4057qib7 13795 35 syndrome syndrome NN cord-005453-4057qib7 13795 36 is be VBZ cord-005453-4057qib7 13795 37 left leave VBN cord-005453-4057qib7 13795 38 untreated untreated JJ cord-005453-4057qib7 13795 39 . . . cord-005453-4057qib7 13796 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 13796 2 stem stem NN cord-005453-4057qib7 13796 3 cell cell NN cord-005453-4057qib7 13796 4 transplantation transplantation NN cord-005453-4057qib7 13796 5 ( ( -LRB- cord-005453-4057qib7 13796 6 HSCT HSCT NNP cord-005453-4057qib7 13796 7 ) ) -RRB- cord-005453-4057qib7 13796 8 is be VBZ cord-005453-4057qib7 13796 9 the the DT cord-005453-4057qib7 13796 10 standard standard NN cord-005453-4057qib7 13796 11 of of IN cord-005453-4057qib7 13796 12 care care NN cord-005453-4057qib7 13796 13 in in IN cord-005453-4057qib7 13796 14 patients patient NNS cord-005453-4057qib7 13796 15 with with IN cord-005453-4057qib7 13796 16 severe severe JJ cord-005453-4057qib7 13796 17 mucopolysaccharidosis mucopolysaccharidosis NN cord-005453-4057qib7 13796 18 ( ( -LRB- cord-005453-4057qib7 13796 19 MPS MPS NNP cord-005453-4057qib7 13796 20 ) ) -RRB- cord-005453-4057qib7 13796 21 type type NN cord-005453-4057qib7 13796 22 I -PRON- PRP cord-005453-4057qib7 13796 23 ( ( -LRB- cord-005453-4057qib7 13796 24 MPSIH MPSIH NNP cord-005453-4057qib7 13796 25 , , , cord-005453-4057qib7 13796 26 Hurler Hurler NNP cord-005453-4057qib7 13796 27 syndrome syndrome NN cord-005453-4057qib7 13796 28 ) ) -RRB- cord-005453-4057qib7 13796 29 as as IN cord-005453-4057qib7 13796 30 early early JJ cord-005453-4057qib7 13796 31 transplantation transplantation NN cord-005453-4057qib7 13796 32 halts halt VBZ cord-005453-4057qib7 13796 33 cognitive cognitive JJ cord-005453-4057qib7 13796 34 decline decline NN cord-005453-4057qib7 13796 35 in in IN cord-005453-4057qib7 13796 36 these these DT cord-005453-4057qib7 13796 37 patients patient NNS cord-005453-4057qib7 13796 38 and and CC cord-005453-4057qib7 13796 39 significantly significantly RB cord-005453-4057qib7 13796 40 improves improve VBZ cord-005453-4057qib7 13796 41 survival survival NN cord-005453-4057qib7 13796 42 . . . cord-005453-4057qib7 13797 1 Only only RB cord-005453-4057qib7 13797 2 few few JJ cord-005453-4057qib7 13797 3 case case NN cord-005453-4057qib7 13797 4 studies study NNS cord-005453-4057qib7 13797 5 have have VBP cord-005453-4057qib7 13797 6 been be VBN cord-005453-4057qib7 13797 7 published publish VBN cord-005453-4057qib7 13797 8 on on IN cord-005453-4057qib7 13797 9 the the DT cord-005453-4057qib7 13797 10 potential potential JJ cord-005453-4057qib7 13797 11 benefit benefit NN cord-005453-4057qib7 13797 12 of of IN cord-005453-4057qib7 13797 13 HSCT HSCT NNP cord-005453-4057qib7 13797 14 in in IN cord-005453-4057qib7 13797 15 MPS MPS NNP cord-005453-4057qib7 13797 16 II II NNP cord-005453-4057qib7 13797 17 and and CC cord-005453-4057qib7 13797 18 mostly mostly RB cord-005453-4057qib7 13797 19 used use VBN cord-005453-4057qib7 13797 20 busulfan busulfan NN cord-005453-4057qib7 13797 21 - - HYPH cord-005453-4057qib7 13797 22 based base VBN cord-005453-4057qib7 13797 23 conditioning conditioning NN cord-005453-4057qib7 13797 24 regimens regimen NNS cord-005453-4057qib7 13797 25 . . . cord-005453-4057qib7 13798 1 In in IN cord-005453-4057qib7 13798 2 one one CD cord-005453-4057qib7 13798 3 comparative comparative JJ cord-005453-4057qib7 13798 4 non non JJ cord-005453-4057qib7 13798 5 - - JJ cord-005453-4057qib7 13798 6 randomised randomised JJ cord-005453-4057qib7 13798 7 multicenter multicenter JJ cord-005453-4057qib7 13798 8 study study NN cord-005453-4057qib7 13798 9 , , , cord-005453-4057qib7 13798 10 HSCT HSCT NNP cord-005453-4057qib7 13798 11 might may MD cord-005453-4057qib7 13798 12 to to TO cord-005453-4057qib7 13798 13 be be VB cord-005453-4057qib7 13798 14 superior superior JJ cord-005453-4057qib7 13798 15 compared compare VBN cord-005453-4057qib7 13798 16 to to IN cord-005453-4057qib7 13798 17 ERT ERT NNP cord-005453-4057qib7 13798 18 . . . cord-005453-4057qib7 13799 1 Here here RB cord-005453-4057qib7 13799 2 , , , cord-005453-4057qib7 13799 3 we -PRON- PRP cord-005453-4057qib7 13799 4 present present VBP cord-005453-4057qib7 13799 5 our -PRON- PRP$ cord-005453-4057qib7 13799 6 experience experience NN cord-005453-4057qib7 13799 7 in in IN cord-005453-4057qib7 13799 8 HSCT HSCT NNP cord-005453-4057qib7 13799 9 in in IN cord-005453-4057qib7 13799 10 three three CD cord-005453-4057qib7 13799 11 children child NNS cord-005453-4057qib7 13799 12 with with IN cord-005453-4057qib7 13799 13 Hunter Hunter NNP cord-005453-4057qib7 13799 14 syndrome syndrome NN cord-005453-4057qib7 13799 15 using use VBG cord-005453-4057qib7 13799 16 a a DT cord-005453-4057qib7 13799 17 treosulfan treosulfan NN cord-005453-4057qib7 13799 18 - - HYPH cord-005453-4057qib7 13799 19 based base VBN cord-005453-4057qib7 13799 20 conditioning conditioning NN cord-005453-4057qib7 13799 21 regimen regimen NN cord-005453-4057qib7 13799 22 . . . cord-005453-4057qib7 13800 1 Methods method NNS cord-005453-4057qib7 13800 2 : : : cord-005453-4057qib7 13800 3 A a DT cord-005453-4057qib7 13800 4 retrospective retrospective JJ cord-005453-4057qib7 13800 5 chart chart NN cord-005453-4057qib7 13800 6 review review NN cord-005453-4057qib7 13800 7 was be VBD cord-005453-4057qib7 13800 8 carried carry VBN cord-005453-4057qib7 13800 9 out out RP cord-005453-4057qib7 13800 10 in in IN cord-005453-4057qib7 13800 11 patients patient NNS cord-005453-4057qib7 13800 12 , , , cord-005453-4057qib7 13800 13 who who WP cord-005453-4057qib7 13800 14 underwent undergo VBD cord-005453-4057qib7 13800 15 HSCT HSCT NNP cord-005453-4057qib7 13800 16 for for IN cord-005453-4057qib7 13800 17 Hunter Hunter NNP cord-005453-4057qib7 13800 18 syndrome syndrome NN cord-005453-4057qib7 13800 19 . . . cord-005453-4057qib7 13801 1 The the DT cord-005453-4057qib7 13801 2 conditioning conditioning NN cord-005453-4057qib7 13801 3 chemotherapy chemotherapy NN cord-005453-4057qib7 13801 4 regimen regimen NN cord-005453-4057qib7 13801 5 included include VBD cord-005453-4057qib7 13801 6 fludarabine fludarabine NN cord-005453-4057qib7 13801 7 , , , cord-005453-4057qib7 13801 8 treosulfan treosulfan NNP cord-005453-4057qib7 13801 9 , , , cord-005453-4057qib7 13801 10 thiotepa thiotepa NNP cord-005453-4057qib7 13801 11 and and CC cord-005453-4057qib7 13801 12 ATG ATG NNP cord-005453-4057qib7 13801 13 . . . cord-005453-4057qib7 13802 1 All all DT cord-005453-4057qib7 13802 2 patients patient NNS cord-005453-4057qib7 13802 3 received receive VBD cord-005453-4057qib7 13802 4 bone bone NN cord-005453-4057qib7 13802 5 marrow marrow NN cord-005453-4057qib7 13802 6 of of IN cord-005453-4057qib7 13802 7 either either CC cord-005453-4057qib7 13802 8 related relate VBN cord-005453-4057qib7 13802 9 and and CC cord-005453-4057qib7 13802 10 or or CC cord-005453-4057qib7 13802 11 matched match VBN cord-005453-4057qib7 13802 12 unrelated unrelated JJ cord-005453-4057qib7 13802 13 donors donor NNS cord-005453-4057qib7 13802 14 . . . cord-005453-4057qib7 13803 1 GvHD GvHD NNP cord-005453-4057qib7 13803 2 prophylaxis prophylaxis NN cord-005453-4057qib7 13803 3 was be VBD cord-005453-4057qib7 13803 4 performed perform VBN cord-005453-4057qib7 13803 5 with with IN cord-005453-4057qib7 13803 6 CsA CsA NNP cord-005453-4057qib7 13803 7 and and CC cord-005453-4057qib7 13803 8 methotrexat methotrexat NNP cord-005453-4057qib7 13803 9 . . . cord-005453-4057qib7 13804 1 Results result NNS cord-005453-4057qib7 13804 2 : : : cord-005453-4057qib7 13805 1 Three three CD cord-005453-4057qib7 13805 2 patients patient NNS cord-005453-4057qib7 13805 3 with with IN cord-005453-4057qib7 13805 4 Hunter Hunter NNP cord-005453-4057qib7 13805 5 syndrome syndrome NN cord-005453-4057qib7 13805 6 were be VBD cord-005453-4057qib7 13805 7 transplanted transplant VBN cord-005453-4057qib7 13805 8 in in IN cord-005453-4057qib7 13805 9 our -PRON- PRP$ cord-005453-4057qib7 13805 10 department department NN cord-005453-4057qib7 13805 11 in in IN cord-005453-4057qib7 13805 12 2010 2010 CD cord-005453-4057qib7 13805 13 . . . cord-005453-4057qib7 13806 1 The the DT cord-005453-4057qib7 13806 2 age age NN cord-005453-4057qib7 13806 3 was be VBD cord-005453-4057qib7 13806 4 six six CD cord-005453-4057qib7 13806 5 months month NNS cord-005453-4057qib7 13806 6 , , , cord-005453-4057qib7 13806 7 two two CD cord-005453-4057qib7 13806 8 years year NNS cord-005453-4057qib7 13806 9 and and CC cord-005453-4057qib7 13806 10 four four CD cord-005453-4057qib7 13806 11 years year NNS cord-005453-4057qib7 13806 12 , , , cord-005453-4057qib7 13806 13 respectively respectively RB cord-005453-4057qib7 13806 14 . . . cord-005453-4057qib7 13807 1 Bone bone NN cord-005453-4057qib7 13807 2 marrow marrow NN cord-005453-4057qib7 13807 3 donors donor NNS cord-005453-4057qib7 13807 4 were be VBD cord-005453-4057qib7 13807 5 related relate VBN cord-005453-4057qib7 13807 6 in in IN cord-005453-4057qib7 13807 7 one one CD cord-005453-4057qib7 13807 8 patient patient NN cord-005453-4057qib7 13807 9 and and CC cord-005453-4057qib7 13807 10 matched match VBN cord-005453-4057qib7 13807 11 unrelated unrelated JJ cord-005453-4057qib7 13807 12 in in IN cord-005453-4057qib7 13807 13 two two CD cord-005453-4057qib7 13807 14 patients patient NNS cord-005453-4057qib7 13807 15 . . . cord-005453-4057qib7 13808 1 The the DT cord-005453-4057qib7 13808 2 conditioning conditioning NN cord-005453-4057qib7 13808 3 therapy therapy NN cord-005453-4057qib7 13808 4 was be VBD cord-005453-4057qib7 13808 5 generally generally RB cord-005453-4057qib7 13808 6 well well RB cord-005453-4057qib7 13808 7 tolerated tolerate VBN cord-005453-4057qib7 13808 8 . . . cord-005453-4057qib7 13809 1 Major major JJ cord-005453-4057qib7 13809 2 complications complication NNS cord-005453-4057qib7 13809 3 were be VBD cord-005453-4057qib7 13809 4 fever fever NN cord-005453-4057qib7 13809 5 of of IN cord-005453-4057qib7 13809 6 unknown unknown JJ cord-005453-4057qib7 13809 7 origin origin NN cord-005453-4057qib7 13809 8 with with IN cord-005453-4057qib7 13809 9 need need NN cord-005453-4057qib7 13809 10 for for IN cord-005453-4057qib7 13809 11 antibiotic antibiotic JJ cord-005453-4057qib7 13809 12 therapy therapy NN cord-005453-4057qib7 13809 13 and and CC cord-005453-4057qib7 13809 14 a a DT cord-005453-4057qib7 13809 15 mucositis mucositis NN cord-005453-4057qib7 13809 16 . . . cord-005453-4057qib7 13810 1 One one CD cord-005453-4057qib7 13810 2 patient patient NN cord-005453-4057qib7 13810 3 developed develop VBD cord-005453-4057qib7 13810 4 a a DT cord-005453-4057qib7 13810 5 CMV CMV NNP cord-005453-4057qib7 13810 6 reactivation reactivation NN cord-005453-4057qib7 13810 7 . . . cord-005453-4057qib7 13811 1 All all DT cord-005453-4057qib7 13811 2 patients patient NNS cord-005453-4057qib7 13811 3 engrafted engraft VBN cord-005453-4057qib7 13811 4 successfully successfully RB cord-005453-4057qib7 13811 5 and and CC cord-005453-4057qib7 13811 6 recovered recover VBD cord-005453-4057qib7 13811 7 well well RB cord-005453-4057qib7 13811 8 from from IN cord-005453-4057qib7 13811 9 the the DT cord-005453-4057qib7 13811 10 HSCT HSCT NNP cord-005453-4057qib7 13811 11 . . . cord-005453-4057qib7 13812 1 There there EX cord-005453-4057qib7 13812 2 was be VBD cord-005453-4057qib7 13812 3 no no DT cord-005453-4057qib7 13812 4 case case NN cord-005453-4057qib7 13812 5 of of IN cord-005453-4057qib7 13812 6 acute acute JJ cord-005453-4057qib7 13812 7 or or CC cord-005453-4057qib7 13812 8 chronic chronic JJ cord-005453-4057qib7 13812 9 GvHD gvhd NN cord-005453-4057qib7 13812 10 . . . cord-005453-4057qib7 13813 1 In in IN cord-005453-4057qib7 13813 2 2018 2018 CD cord-005453-4057qib7 13813 3 all all DT cord-005453-4057qib7 13813 4 three three CD cord-005453-4057qib7 13813 5 patients patient NNS cord-005453-4057qib7 13813 6 are be VBP cord-005453-4057qib7 13813 7 alive alive JJ cord-005453-4057qib7 13813 8 . . . cord-005453-4057qib7 13814 1 Donor donor NN cord-005453-4057qib7 13814 2 chimerism chimerism NN cord-005453-4057qib7 13814 3 is be VBZ cord-005453-4057qib7 13814 4 complete complete JJ cord-005453-4057qib7 13814 5 in in IN cord-005453-4057qib7 13814 6 one one CD cord-005453-4057qib7 13814 7 patient patient NN cord-005453-4057qib7 13814 8 ; ; : cord-005453-4057qib7 13814 9 two two CD cord-005453-4057qib7 13814 10 patients patient NNS cord-005453-4057qib7 13814 11 have have VBP cord-005453-4057qib7 13814 12 a a DT cord-005453-4057qib7 13814 13 mixed mixed JJ cord-005453-4057qib7 13814 14 donor donor NN cord-005453-4057qib7 13814 15 chimerism chimerism NN cord-005453-4057qib7 13814 16 . . . cord-005453-4057qib7 13815 1 After after IN cord-005453-4057qib7 13815 2 application application NN cord-005453-4057qib7 13815 3 of of IN cord-005453-4057qib7 13815 4 donor donor NN cord-005453-4057qib7 13815 5 lymphocyte lymphocyte NN cord-005453-4057qib7 13815 6 infusions infusion NNS cord-005453-4057qib7 13815 7 in in IN cord-005453-4057qib7 13815 8 one one CD cord-005453-4057qib7 13815 9 patient patient NN cord-005453-4057qib7 13815 10 , , , cord-005453-4057qib7 13815 11 donor donor NN cord-005453-4057qib7 13815 12 chimerism chimerism NN cord-005453-4057qib7 13815 13 is be VBZ cord-005453-4057qib7 13815 14 stable stable JJ cord-005453-4057qib7 13815 15 at at IN cord-005453-4057qib7 13815 16 a a DT cord-005453-4057qib7 13815 17 low low JJ cord-005453-4057qib7 13815 18 level level NN cord-005453-4057qib7 13815 19 of of IN cord-005453-4057qib7 13815 20 16 16 CD cord-005453-4057qib7 13815 21 % % NN cord-005453-4057qib7 13815 22 . . . cord-005453-4057qib7 13816 1 The the DT cord-005453-4057qib7 13816 2 donor donor NN cord-005453-4057qib7 13816 3 chimerism chimerism NN cord-005453-4057qib7 13816 4 of of IN cord-005453-4057qib7 13816 5 the the DT cord-005453-4057qib7 13816 6 other other JJ cord-005453-4057qib7 13816 7 patient patient NN cord-005453-4057qib7 13816 8 still still RB cord-005453-4057qib7 13816 9 slowly slowly RB cord-005453-4057qib7 13816 10 declines decline VBZ cord-005453-4057qib7 13816 11 to to IN cord-005453-4057qib7 13816 12 currently currently RB cord-005453-4057qib7 13816 13 50 50 CD cord-005453-4057qib7 13816 14 % % NN cord-005453-4057qib7 13816 15 . . . cord-005453-4057qib7 13817 1 After after IN cord-005453-4057qib7 13817 2 stem stem NN cord-005453-4057qib7 13817 3 cell cell NN cord-005453-4057qib7 13817 4 transplantation transplantation NN cord-005453-4057qib7 13817 5 , , , cord-005453-4057qib7 13817 6 two two CD cord-005453-4057qib7 13817 7 patients patient NNS cord-005453-4057qib7 13817 8 did do VBD cord-005453-4057qib7 13817 9 not not RB cord-005453-4057qib7 13817 10 show show VB cord-005453-4057qib7 13817 11 further further JJ cord-005453-4057qib7 13817 12 progression progression NN cord-005453-4057qib7 13817 13 of of IN cord-005453-4057qib7 13817 14 the the DT cord-005453-4057qib7 13817 15 disease disease NN cord-005453-4057qib7 13817 16 and and CC cord-005453-4057qib7 13817 17 even even RB cord-005453-4057qib7 13817 18 achieved achieve VBD cord-005453-4057qib7 13817 19 psycho psycho JJ cord-005453-4057qib7 13817 20 - - HYPH cord-005453-4057qib7 13817 21 motor motor NN cord-005453-4057qib7 13817 22 improvements improvement NNS cord-005453-4057qib7 13817 23 . . . cord-005453-4057qib7 13818 1 Interestingly interestingly RB cord-005453-4057qib7 13818 2 , , , cord-005453-4057qib7 13818 3 one one CD cord-005453-4057qib7 13818 4 of of IN cord-005453-4057qib7 13818 5 these these DT cord-005453-4057qib7 13818 6 patients patient NNS cord-005453-4057qib7 13818 7 is be VBZ cord-005453-4057qib7 13818 8 the the DT cord-005453-4057qib7 13818 9 one one NN cord-005453-4057qib7 13818 10 with with IN cord-005453-4057qib7 13818 11 the the DT cord-005453-4057qib7 13818 12 low low JJ cord-005453-4057qib7 13818 13 donor donor NN cord-005453-4057qib7 13818 14 chimerism chimerism NN cord-005453-4057qib7 13818 15 of of IN cord-005453-4057qib7 13818 16 16 16 CD cord-005453-4057qib7 13818 17 % % NN cord-005453-4057qib7 13818 18 . . . cord-005453-4057qib7 13819 1 One one CD cord-005453-4057qib7 13819 2 patient patient NN cord-005453-4057qib7 13819 3 suffers suffer VBZ cord-005453-4057qib7 13819 4 from from IN cord-005453-4057qib7 13819 5 a a DT cord-005453-4057qib7 13819 6 further further JJ cord-005453-4057qib7 13819 7 progression progression NN cord-005453-4057qib7 13819 8 of of IN cord-005453-4057qib7 13819 9 the the DT cord-005453-4057qib7 13819 10 underlying underlie VBG cord-005453-4057qib7 13819 11 disease disease NN cord-005453-4057qib7 13819 12 with with IN cord-005453-4057qib7 13819 13 psycho psycho JJ cord-005453-4057qib7 13819 14 - - HYPH cord-005453-4057qib7 13819 15 motoric motoric JJ cord-005453-4057qib7 13819 16 agitation agitation NN cord-005453-4057qib7 13819 17 , , , cord-005453-4057qib7 13819 18 aggressive aggressive JJ cord-005453-4057qib7 13819 19 behavior behavior NN cord-005453-4057qib7 13819 20 and and CC cord-005453-4057qib7 13819 21 loss loss NN cord-005453-4057qib7 13819 22 of of IN cord-005453-4057qib7 13819 23 speech speech NN cord-005453-4057qib7 13819 24 , , , cord-005453-4057qib7 13819 25 that that WDT cord-005453-4057qib7 13819 26 occurred occur VBD cord-005453-4057qib7 13819 27 within within IN cord-005453-4057qib7 13819 28 the the DT cord-005453-4057qib7 13819 29 first first JJ cord-005453-4057qib7 13819 30 year year NN cord-005453-4057qib7 13819 31 following follow VBG cord-005453-4057qib7 13819 32 HSCT HSCT NNP cord-005453-4057qib7 13819 33 , , , cord-005453-4057qib7 13819 34 but but CC cord-005453-4057qib7 13819 35 neurocognition neurocognition NN cord-005453-4057qib7 13819 36 stabilized stabilize VBN cord-005453-4057qib7 13819 37 thereafter thereafter RB cord-005453-4057qib7 13819 38 . . . cord-005453-4057qib7 13820 1 Conclusions conclusion NNS cord-005453-4057qib7 13820 2 : : : cord-005453-4057qib7 13821 1 We -PRON- PRP cord-005453-4057qib7 13821 2 found find VBD cord-005453-4057qib7 13821 3 a a DT cord-005453-4057qib7 13821 4 beneficial beneficial JJ cord-005453-4057qib7 13821 5 effect effect NN cord-005453-4057qib7 13821 6 of of IN cord-005453-4057qib7 13821 7 HSCT HSCT NNP cord-005453-4057qib7 13821 8 on on IN cord-005453-4057qib7 13821 9 the the DT cord-005453-4057qib7 13821 10 neuropsychological neuropsychological JJ cord-005453-4057qib7 13821 11 outcome outcome NN cord-005453-4057qib7 13821 12 or or CC cord-005453-4057qib7 13821 13 at at IN cord-005453-4057qib7 13821 14 least least JJS cord-005453-4057qib7 13821 15 stabilization stabilization NN cord-005453-4057qib7 13821 16 of of IN cord-005453-4057qib7 13821 17 neurocognitive neurocognitive JJ cord-005453-4057qib7 13821 18 function function NN cord-005453-4057qib7 13821 19 in in IN cord-005453-4057qib7 13821 20 our -PRON- PRP$ cord-005453-4057qib7 13821 21 patients patient NNS cord-005453-4057qib7 13821 22 with with IN cord-005453-4057qib7 13821 23 a a DT cord-005453-4057qib7 13821 24 follow follow NN cord-005453-4057qib7 13821 25 - - HYPH cord-005453-4057qib7 13821 26 up up NN cord-005453-4057qib7 13821 27 of of IN cord-005453-4057qib7 13821 28 eight eight CD cord-005453-4057qib7 13821 29 years year NNS cord-005453-4057qib7 13821 30 . . . cord-005453-4057qib7 13822 1 Despite despite IN cord-005453-4057qib7 13822 2 low low JJ cord-005453-4057qib7 13822 3 toxicity toxicity NN cord-005453-4057qib7 13822 4 of of IN cord-005453-4057qib7 13822 5 the the DT cord-005453-4057qib7 13822 6 conditioning conditioning NN cord-005453-4057qib7 13822 7 regimen regimen NN cord-005453-4057qib7 13822 8 , , , cord-005453-4057qib7 13822 9 increased increase VBN cord-005453-4057qib7 13822 10 donor donor NN cord-005453-4057qib7 13822 11 chimerism chimerism NN cord-005453-4057qib7 13822 12 may may MD cord-005453-4057qib7 13822 13 further further RB cord-005453-4057qib7 13822 14 improve improve VB cord-005453-4057qib7 13822 15 the the DT cord-005453-4057qib7 13822 16 neurological neurological JJ cord-005453-4057qib7 13822 17 outcome outcome NN cord-005453-4057qib7 13822 18 . . . cord-005453-4057qib7 13823 1 Disclosure disclosure NN cord-005453-4057qib7 13823 2 : : : cord-005453-4057qib7 13823 3 Nothing nothing NN cord-005453-4057qib7 13823 4 to to TO cord-005453-4057qib7 13823 5 declare declare VB cord-005453-4057qib7 13823 6 . . . cord-005453-4057qib7 13824 1 Tandem tandem JJ cord-005453-4057qib7 13824 2 sct sct NN cord-005453-4057qib7 13824 3 in in IN cord-005453-4057qib7 13824 4 pediatric pediatric JJ cord-005453-4057qib7 13824 5 solid solid JJ cord-005453-4057qib7 13824 6 tumors tumor NNS cord-005453-4057qib7 13824 7 , , , cord-005453-4057qib7 13824 8 other other JJ cord-005453-4057qib7 13824 9 than than IN cord-005453-4057qib7 13824 10 brain brain NN cord-005453-4057qib7 13824 11 tumors tumor NNS cord-005453-4057qib7 13824 12 , , , cord-005453-4057qib7 13824 13 has have VBZ cord-005453-4057qib7 13824 14 no no DT cord-005453-4057qib7 13824 15 advantage advantage NN cord-005453-4057qib7 13824 16 in in IN cord-005453-4057qib7 13824 17 terms term NNS cord-005453-4057qib7 13824 18 of of IN cord-005453-4057qib7 13824 19 EFS efs NN cord-005453-4057qib7 13824 20 over over IN cord-005453-4057qib7 13824 21 single single JJ cord-005453-4057qib7 13824 22 procedure procedure NN cord-005453-4057qib7 13824 23 - - HYPH cord-005453-4057qib7 13824 24 single single JJ cord-005453-4057qib7 13824 25 center center NN cord-005453-4057qib7 13824 26 experience experience NN cord-005453-4057qib7 13824 27 , , , cord-005453-4057qib7 13824 28 germ germ NN cord-005453-4057qib7 13824 29 - - HYPH cord-005453-4057qib7 13824 30 cell cell NN cord-005453-4057qib7 13824 31 tumour tumour NN cord-005453-4057qib7 13824 32 ( ( -LRB- cord-005453-4057qib7 13824 33 GCT GCT NNP cord-005453-4057qib7 13824 34 ) ) -RRB- cord-005453-4057qib7 13824 35 , , , cord-005453-4057qib7 13824 36 Ewing Ewing NNP cord-005453-4057qib7 13824 37 sarcoma sarcoma NN cord-005453-4057qib7 13824 38 ( ( -LRB- cord-005453-4057qib7 13824 39 ES ES NNP cord-005453-4057qib7 13824 40 ) ) -RRB- cord-005453-4057qib7 13824 41 , , , cord-005453-4057qib7 13824 42 nefroblastoma nefroblastoma NNP cord-005453-4057qib7 13824 43 . . . cord-005453-4057qib7 13825 1 Patients patient NNS cord-005453-4057qib7 13825 2 were be VBD cord-005453-4057qib7 13825 3 divided divide VBN cord-005453-4057qib7 13825 4 into into IN cord-005453-4057qib7 13825 5 2 2 CD cord-005453-4057qib7 13825 6 groups group NNS cord-005453-4057qib7 13825 7 according accord VBG cord-005453-4057qib7 13825 8 to to IN cord-005453-4057qib7 13825 9 the the DT cord-005453-4057qib7 13825 10 number number NN cord-005453-4057qib7 13825 11 of of IN cord-005453-4057qib7 13825 12 procedures procedure NNS cord-005453-4057qib7 13825 13 : : : cord-005453-4057qib7 13825 14 1st 1st JJ cord-005453-4057qib7 13825 15 group group NN cord-005453-4057qib7 13825 16 - - HYPH cord-005453-4057qib7 13825 17 single single JJ cord-005453-4057qib7 13825 18 SCT SCT NNP cord-005453-4057qib7 13825 19 procedure procedure NN cord-005453-4057qib7 13825 20 , , , cord-005453-4057qib7 13825 21 2nd 2nd JJ cord-005453-4057qib7 13825 22 group group NN cord-005453-4057qib7 13825 23 - - HYPH cord-005453-4057qib7 13825 24 multiple multiple JJ cord-005453-4057qib7 13825 25 procedures procedure NNS cord-005453-4057qib7 13825 26 . . . cord-005453-4057qib7 13826 1 Regimens regimen NNS cord-005453-4057qib7 13826 2 used use VBN cord-005453-4057qib7 13826 3 for for IN cord-005453-4057qib7 13826 4 stem stem NN cord-005453-4057qib7 13826 5 cell cell NN cord-005453-4057qib7 13826 6 mobilisation mobilisation NN cord-005453-4057qib7 13826 7 were be VBD cord-005453-4057qib7 13826 8 : : : cord-005453-4057qib7 13827 1 Topo Topo NNP cord-005453-4057qib7 13827 2 - - HYPH cord-005453-4057qib7 13827 3 Cy Cy NNP cord-005453-4057qib7 13827 4 for for IN cord-005453-4057qib7 13827 5 NBL NBL NNP cord-005453-4057qib7 13827 6 and and CC cord-005453-4057qib7 13827 7 Epi Epi NNP cord-005453-4057qib7 13827 8 - - HYPH cord-005453-4057qib7 13827 9 Tax Tax NNP cord-005453-4057qib7 13827 10 for for IN cord-005453-4057qib7 13827 11 GCT GCT NNP cord-005453-4057qib7 13827 12 , , , cord-005453-4057qib7 13827 13 followed follow VBN cord-005453-4057qib7 13827 14 by by IN cord-005453-4057qib7 13827 15 G G NNP cord-005453-4057qib7 13827 16 - - HYPH cord-005453-4057qib7 13827 17 CSF±Plerixafor CSF±Plerixafor NNP cord-005453-4057qib7 13827 18 . . . cord-005453-4057qib7 13828 1 Conditioning conditioning NN cord-005453-4057qib7 13828 2 regimens regimen NNS cord-005453-4057qib7 13828 3 : : : cord-005453-4057qib7 13829 1 Bu Bu NNP cord-005453-4057qib7 13829 2 - - HYPH cord-005453-4057qib7 13829 3 Mel Mel NNP cord-005453-4057qib7 13829 4 and and CC cord-005453-4057qib7 13829 5 Thiotepa Thiotepa NNP cord-005453-4057qib7 13829 6 - - HYPH cord-005453-4057qib7 13829 7 Cy Cy NNP cord-005453-4057qib7 13829 8 for for IN cord-005453-4057qib7 13829 9 pts pt NNS cord-005453-4057qib7 13829 10 with with IN cord-005453-4057qib7 13829 11 NBL NBL NNP cord-005453-4057qib7 13829 12 , , , cord-005453-4057qib7 13829 13 Thio Thio NNP cord-005453-4057qib7 13829 14 - - HYPH cord-005453-4057qib7 13829 15 Tax Tax NNP cord-005453-4057qib7 13829 16 and and CC cord-005453-4057qib7 13829 17 ICE ice NN cord-005453-4057qib7 13829 18 for for IN cord-005453-4057qib7 13829 19 pts pt NNS cord-005453-4057qib7 13829 20 with with IN cord-005453-4057qib7 13829 21 GCT GCT NNP cord-005453-4057qib7 13829 22 . . . cord-005453-4057qib7 13830 1 Patients patient NNS cord-005453-4057qib7 13830 2 received receive VBD cord-005453-4057qib7 13830 3 antibiotic antibiotic JJ cord-005453-4057qib7 13830 4 , , , cord-005453-4057qib7 13830 5 antiviral antiviral JJ cord-005453-4057qib7 13830 6 and and CC cord-005453-4057qib7 13830 7 antifungal antifungal JJ cord-005453-4057qib7 13830 8 prophylaxis prophylaxis NN cord-005453-4057qib7 13830 9 , , , cord-005453-4057qib7 13830 10 parenteral parenteral JJ cord-005453-4057qib7 13830 11 nutrition nutrition NN cord-005453-4057qib7 13830 12 and and CC cord-005453-4057qib7 13830 13 supportive supportive JJ cord-005453-4057qib7 13830 14 treatment treatment NN cord-005453-4057qib7 13830 15 . . . cord-005453-4057qib7 13831 1 Patients patient NNS cord-005453-4057qib7 13831 2 received receive VBD cord-005453-4057qib7 13831 3 consolidation consolidation NN cord-005453-4057qib7 13831 4 treatment treatment NN cord-005453-4057qib7 13831 5 , , , cord-005453-4057qib7 13831 6 followed follow VBD cord-005453-4057qib7 13831 7 up up RP cord-005453-4057qib7 13831 8 monthly monthly RB cord-005453-4057qib7 13831 9 in in IN cord-005453-4057qib7 13831 10 the the DT cord-005453-4057qib7 13831 11 first first JJ cord-005453-4057qib7 13831 12 year year NN cord-005453-4057qib7 13831 13 , , , cord-005453-4057qib7 13831 14 then then RB cord-005453-4057qib7 13831 15 yearly yearly RB cord-005453-4057qib7 13831 16 . . . cord-005453-4057qib7 13832 1 Patients patient NNS cord-005453-4057qib7 13832 2 were be VBD cord-005453-4057qib7 13832 3 evaluated evaluate VBN cord-005453-4057qib7 13832 4 for for IN cord-005453-4057qib7 13832 5 residual residual JJ cord-005453-4057qib7 13832 6 disease disease NN cord-005453-4057qib7 13832 7 by by IN cord-005453-4057qib7 13832 8 imaging image VBG cord-005453-4057qib7 13832 9 tests test NNS cord-005453-4057qib7 13832 10 . . . cord-005453-4057qib7 13833 1 Parents parent NNS cord-005453-4057qib7 13833 2 signed sign VBD cord-005453-4057qib7 13833 3 informed informed JJ cord-005453-4057qib7 13833 4 consent consent NN cord-005453-4057qib7 13833 5 forms form NNS cord-005453-4057qib7 13833 6 . . . cord-005453-4057qib7 13834 1 Results result NNS cord-005453-4057qib7 13834 2 : : : cord-005453-4057qib7 13835 1 We -PRON- PRP cord-005453-4057qib7 13835 2 performed perform VBD cord-005453-4057qib7 13835 3 67 67 CD cord-005453-4057qib7 13835 4 SCT SCT NNP cord-005453-4057qib7 13835 5 procedures procedure NNS cord-005453-4057qib7 13835 6 to to IN cord-005453-4057qib7 13835 7 52 52 CD cord-005453-4057qib7 13835 8 patients patient NNS cord-005453-4057qib7 13835 9 : : : cord-005453-4057qib7 13835 10 65.3 65.3 CD cord-005453-4057qib7 13835 11 % % NN cord-005453-4057qib7 13835 12 NBL NBL NNP cord-005453-4057qib7 13835 13 , , , cord-005453-4057qib7 13835 14 17.3 17.3 CD cord-005453-4057qib7 13835 15 % % NN cord-005453-4057qib7 13835 16 ES ES NNP cord-005453-4057qib7 13835 17 , , , cord-005453-4057qib7 13835 18 11.6 11.6 CD cord-005453-4057qib7 13835 19 % % NN cord-005453-4057qib7 13835 20 GCT GCT NNP cord-005453-4057qib7 13835 21 and and CC cord-005453-4057qib7 13835 22 5.8 5.8 CD cord-005453-4057qib7 13835 23 % % NN cord-005453-4057qib7 13835 24 nefroblastoma nefroblastoma NN cord-005453-4057qib7 13835 25 . . . cord-005453-4057qib7 13836 1 For for IN cord-005453-4057qib7 13836 2 this this DT cord-005453-4057qib7 13836 3 study study NN cord-005453-4057qib7 13836 4 only only RB cord-005453-4057qib7 13836 5 patients patient NNS cord-005453-4057qib7 13836 6 with with IN cord-005453-4057qib7 13836 7 NBL NBL NNP cord-005453-4057qib7 13836 8 and and CC cord-005453-4057qib7 13836 9 GCT GCT NNP cord-005453-4057qib7 13836 10 were be VBD cord-005453-4057qib7 13836 11 considered consider VBN cord-005453-4057qib7 13836 12 . . . cord-005453-4057qib7 13837 1 In in IN cord-005453-4057qib7 13837 2 1st 1st JJ cord-005453-4057qib7 13837 3 group group NN cord-005453-4057qib7 13837 4 were be VBD cord-005453-4057qib7 13837 5 79 79 CD cord-005453-4057qib7 13837 6 % % NN cord-005453-4057qib7 13837 7 of of IN cord-005453-4057qib7 13837 8 pts pt NNS cord-005453-4057qib7 13837 9 , , , cord-005453-4057qib7 13837 10 21 21 CD cord-005453-4057qib7 13837 11 % % NN cord-005453-4057qib7 13837 12 in in IN cord-005453-4057qib7 13837 13 2nd 2nd JJ cord-005453-4057qib7 13837 14 group group NN cord-005453-4057qib7 13837 15 . . . cord-005453-4057qib7 13838 1 Patients patient NNS cord-005453-4057qib7 13838 2 were be VBD cord-005453-4057qib7 13838 3 diagnosed diagnose VBN cord-005453-4057qib7 13838 4 , , , cord-005453-4057qib7 13838 5 staged stage VBD cord-005453-4057qib7 13838 6 and and CC cord-005453-4057qib7 13838 7 treated treat VBN cord-005453-4057qib7 13838 8 according accord VBG cord-005453-4057qib7 13838 9 to to IN cord-005453-4057qib7 13838 10 international international JJ cord-005453-4057qib7 13838 11 protocols protocol NNS cord-005453-4057qib7 13838 12 . . . cord-005453-4057qib7 13839 1 Sex sex NN cord-005453-4057qib7 13839 2 ratio ratio NN cord-005453-4057qib7 13839 3 was be VBD cord-005453-4057qib7 13839 4 18F/34M. 18f/34m. CD cord-005453-4057qib7 13839 5 Age age NN cord-005453-4057qib7 13839 6 distribution distribution NN cord-005453-4057qib7 13839 7 was be VBD cord-005453-4057qib7 13839 8 1 1 CD cord-005453-4057qib7 13839 9 - - SYM cord-005453-4057qib7 13839 10 4 4 CD cord-005453-4057qib7 13839 11 y y NN cord-005453-4057qib7 13839 12 38 38 CD cord-005453-4057qib7 13839 13 % % NN cord-005453-4057qib7 13839 14 ( ( -LRB- cord-005453-4057qib7 13839 15 20 20 CD cord-005453-4057qib7 13839 16 pts pt NNS cord-005453-4057qib7 13839 17 ) ) -RRB- cord-005453-4057qib7 13839 18 , , , cord-005453-4057qib7 13839 19 4 4 CD cord-005453-4057qib7 13839 20 - - SYM cord-005453-4057qib7 13839 21 10 10 CD cord-005453-4057qib7 13839 22 y y NNP cord-005453-4057qib7 13839 23 35 35 CD cord-005453-4057qib7 13839 24 % % NN cord-005453-4057qib7 13839 25 ( ( -LRB- cord-005453-4057qib7 13839 26 18 18 CD cord-005453-4057qib7 13839 27 pts pt NNS cord-005453-4057qib7 13839 28 ) ) -RRB- cord-005453-4057qib7 13839 29 , , , cord-005453-4057qib7 13839 30 > > XX cord-005453-4057qib7 13839 31 10 10 CD cord-005453-4057qib7 13839 32 y y NNP cord-005453-4057qib7 13839 33 27 27 CD cord-005453-4057qib7 13839 34 % % NN cord-005453-4057qib7 13839 35 ( ( -LRB- cord-005453-4057qib7 13839 36 14 14 CD cord-005453-4057qib7 13839 37 pts pt NNS cord-005453-4057qib7 13839 38 ) ) -RRB- cord-005453-4057qib7 13839 39 . . . cord-005453-4057qib7 13840 1 Peripheral peripheral JJ cord-005453-4057qib7 13840 2 stem stem NN cord-005453-4057qib7 13840 3 cell cell NN cord-005453-4057qib7 13840 4 ( ( -LRB- cord-005453-4057qib7 13840 5 PBSC PBSC NNP cord-005453-4057qib7 13840 6 ) ) -RRB- cord-005453-4057qib7 13840 7 mobilisation mobilisation NN cord-005453-4057qib7 13840 8 was be VBD cord-005453-4057qib7 13840 9 more more RBR cord-005453-4057qib7 13840 10 difficult difficult JJ cord-005453-4057qib7 13840 11 in in IN cord-005453-4057qib7 13840 12 patients patient NNS cord-005453-4057qib7 13840 13 with with IN cord-005453-4057qib7 13840 14 multiple multiple JJ cord-005453-4057qib7 13840 15 courses course NNS cord-005453-4057qib7 13840 16 of of IN cord-005453-4057qib7 13840 17 chemotherapy±radiotherapy chemotherapy±radiotherapy CD cord-005453-4057qib7 13840 18 . . . cord-005453-4057qib7 13841 1 We -PRON- PRP cord-005453-4057qib7 13841 2 found find VBD cord-005453-4057qib7 13841 3 no no DT cord-005453-4057qib7 13841 4 difference difference NN cord-005453-4057qib7 13841 5 in in IN cord-005453-4057qib7 13841 6 the the DT cord-005453-4057qib7 13841 7 period period NN cord-005453-4057qib7 13841 8 of of IN cord-005453-4057qib7 13841 9 engraftment engraftment NN cord-005453-4057qib7 13841 10 following follow VBG cord-005453-4057qib7 13841 11 a a DT cord-005453-4057qib7 13841 12 2nd 2nd JJ cord-005453-4057qib7 13841 13 or or CC cord-005453-4057qib7 13841 14 3rd 3rd JJ cord-005453-4057qib7 13841 15 procedure procedure NN cord-005453-4057qib7 13841 16 . . . cord-005453-4057qib7 13842 1 Hospitalization hospitalization NN cord-005453-4057qib7 13842 2 and and CC cord-005453-4057qib7 13842 3 supportive supportive JJ cord-005453-4057qib7 13842 4 measures measure NNS cord-005453-4057qib7 13842 5 increased increase VBD cord-005453-4057qib7 13842 6 in in IN cord-005453-4057qib7 13842 7 2nd 2nd JJ cord-005453-4057qib7 13842 8 and and CC cord-005453-4057qib7 13842 9 3rd 3rd JJ cord-005453-4057qib7 13842 10 procedures procedure NNS cord-005453-4057qib7 13842 11 ( ( -LRB- cord-005453-4057qib7 13842 12 26 26 CD cord-005453-4057qib7 13842 13 to to TO cord-005453-4057qib7 13842 14 29 29 CD cord-005453-4057qib7 13842 15 days day NNS cord-005453-4057qib7 13842 16 ) ) -RRB- cord-005453-4057qib7 13842 17 . . . cord-005453-4057qib7 13843 1 Patients patient NNS cord-005453-4057qib7 13843 2 with with IN cord-005453-4057qib7 13843 3 multiple multiple JJ cord-005453-4057qib7 13843 4 courses course NNS cord-005453-4057qib7 13843 5 of of IN cord-005453-4057qib7 13843 6 chemotherapy chemotherapy NN cord-005453-4057qib7 13843 7 and and CC cord-005453-4057qib7 13843 8 multiple multiple JJ cord-005453-4057qib7 13843 9 hospitalizations hospitalization NNS cord-005453-4057qib7 13843 10 had have VBD cord-005453-4057qib7 13843 11 increased increase VBN cord-005453-4057qib7 13843 12 infectious infectious JJ cord-005453-4057qib7 13843 13 risk risk NN cord-005453-4057qib7 13843 14 and and CC cord-005453-4057qib7 13843 15 during during IN cord-005453-4057qib7 13843 16 the the DT cord-005453-4057qib7 13843 17 2nd 2nd JJ cord-005453-4057qib7 13843 18 or or CC cord-005453-4057qib7 13843 19 3rd 3rd JJ cord-005453-4057qib7 13843 20 procedures procedure NNS cord-005453-4057qib7 13843 21 developed develop VBD cord-005453-4057qib7 13843 22 various various JJ cord-005453-4057qib7 13843 23 infectious infectious JJ cord-005453-4057qib7 13843 24 complications complication NNS cord-005453-4057qib7 13843 25 . . . cord-005453-4057qib7 13844 1 Incidence incidence NN cord-005453-4057qib7 13844 2 of of IN cord-005453-4057qib7 13844 3 severe severe JJ cord-005453-4057qib7 13844 4 oral oral JJ cord-005453-4057qib7 13844 5 mucositis mucositis NN cord-005453-4057qib7 13844 6 after after IN cord-005453-4057qib7 13844 7 the the DT cord-005453-4057qib7 13844 8 first first JJ cord-005453-4057qib7 13844 9 HSCT HSCT NNP cord-005453-4057qib7 13844 10 was be VBD cord-005453-4057qib7 13844 11 17 17 CD cord-005453-4057qib7 13844 12 % % NN cord-005453-4057qib7 13844 13 , , , cord-005453-4057qib7 13844 14 after after IN cord-005453-4057qib7 13844 15 tandem tandem NN cord-005453-4057qib7 13844 16 HSCT HSCT NNP cord-005453-4057qib7 13844 17 was be VBD cord-005453-4057qib7 13844 18 69 69 CD cord-005453-4057qib7 13844 19 % % NN cord-005453-4057qib7 13844 20 . . . cord-005453-4057qib7 13845 1 NBL NBL NNP cord-005453-4057qib7 13845 2 patients patient NNS cord-005453-4057qib7 13845 3 : : : cord-005453-4057qib7 13846 1 1st 1st JJ cord-005453-4057qib7 13846 2 group-6/23 group-6/23 NNP cord-005453-4057qib7 13846 3 patients patient NNS cord-005453-4057qib7 13846 4 alive alive JJ cord-005453-4057qib7 13846 5 and and CC cord-005453-4057qib7 13846 6 EFS EFS NNP cord-005453-4057qib7 13846 7 , , , cord-005453-4057qib7 13846 8 1/23 1/23 CD cord-005453-4057qib7 13846 9 receives receive VBZ cord-005453-4057qib7 13846 10 anti anti JJ cord-005453-4057qib7 13846 11 G2 G2 NNP cord-005453-4057qib7 13846 12 treatment treatment NN cord-005453-4057qib7 13846 13 ; ; : cord-005453-4057qib7 13847 1 2nd 2nd JJ cord-005453-4057qib7 13847 2 group-1/7 group-1/7 JJ cord-005453-4057qib7 13847 3 patients patient NNS cord-005453-4057qib7 13847 4 - - : cord-005453-4057qib7 13847 5 alive alive JJ cord-005453-4057qib7 13847 6 , , , cord-005453-4057qib7 13847 7 2/7 2/7 CD cord-005453-4057qib7 13847 8 patients patient NNS cord-005453-4057qib7 13847 9 - - : cord-005453-4057qib7 13847 10 not not RB cord-005453-4057qib7 13847 11 reached reach VBN cord-005453-4057qib7 13847 12 timepoint timepoint NN cord-005453-4057qib7 13847 13 for for IN cord-005453-4057qib7 13847 14 mIBG mIBG NNP cord-005453-4057qib7 13847 15 scan scan NNP cord-005453-4057qib7 13847 16 ; ; : cord-005453-4057qib7 13847 17 4/7 4/7 CD cord-005453-4057qib7 13847 18 patients patient NNS cord-005453-4057qib7 13847 19 - - HYPH cord-005453-4057qib7 13847 20 mIBG mIBG NNP cord-005453-4057qib7 13847 21 negative negative NN cord-005453-4057qib7 13847 22 at at IN cord-005453-4057qib7 13847 23 first first RB cord-005453-4057qib7 13847 24 , , , cord-005453-4057qib7 13847 25 relapsed relapse VBN cord-005453-4057qib7 13847 26 after after IN cord-005453-4057qib7 13847 27 6 6 CD cord-005453-4057qib7 13847 28 mo mo NN cord-005453-4057qib7 13847 29 ; ; : cord-005453-4057qib7 13848 1 1/7 1/7 CD cord-005453-4057qib7 13848 2 patient patient NN cord-005453-4057qib7 13848 3 deceased decease VBN cord-005453-4057qib7 13848 4 due due IN cord-005453-4057qib7 13848 5 to to IN cord-005453-4057qib7 13848 6 pulmonary pulmonary JJ cord-005453-4057qib7 13848 7 toxicity toxicity NN cord-005453-4057qib7 13848 8 . . . cord-005453-4057qib7 13849 1 GCT GCT NNP cord-005453-4057qib7 13849 2 patients patient NNS cord-005453-4057qib7 13849 3 : : : cord-005453-4057qib7 13850 1 1st 1st NN cord-005453-4057qib7 13851 1 group-1/5 group-1/5 NNP cord-005453-4057qib7 13851 2 patients patient NNS cord-005453-4057qib7 13851 3 alive alive JJ cord-005453-4057qib7 13851 4 and and CC cord-005453-4057qib7 13851 5 EF EF NNP cord-005453-4057qib7 13851 6 , , , cord-005453-4057qib7 13851 7 1/5 1/5 DT cord-005453-4057qib7 13851 8 high high JJ cord-005453-4057qib7 13851 9 values value NNS cord-005453-4057qib7 13851 10 in in IN cord-005453-4057qib7 13851 11 AFP AFP NNP cord-005453-4057qib7 13851 12 levels level NNS cord-005453-4057qib7 13851 13 and and CC cord-005453-4057qib7 13851 14 receives receive VBZ cord-005453-4057qib7 13851 15 metronomic metronomic JJ cord-005453-4057qib7 13851 16 therapy therapy NN cord-005453-4057qib7 13851 17 , , , cord-005453-4057qib7 13851 18 3/5 3/5 CD cord-005453-4057qib7 13851 19 patients patient NNS cord-005453-4057qib7 13851 20 deceased decease VBN cord-005453-4057qib7 13851 21 due due IN cord-005453-4057qib7 13851 22 to to IN cord-005453-4057qib7 13851 23 progressive progressive JJ cord-005453-4057qib7 13851 24 disease disease NN cord-005453-4057qib7 13851 25 , , , cord-005453-4057qib7 13851 26 but but CC cord-005453-4057qib7 13851 27 only only RB cord-005453-4057qib7 13851 28 had have VBD cord-005453-4057qib7 13851 29 2 2 CD cord-005453-4057qib7 13851 30 SCT SCT NNP cord-005453-4057qib7 13851 31 . . . cord-005453-4057qib7 13852 1 Only only RB cord-005453-4057qib7 13852 2 1/5 1/5 DT cord-005453-4057qib7 13852 3 patient patient NN cord-005453-4057qib7 13852 4 had have VBD cord-005453-4057qib7 13852 5 one one CD cord-005453-4057qib7 13852 6 procedure procedure NN cord-005453-4057qib7 13852 7 and and CC cord-005453-4057qib7 13852 8 died die VBD cord-005453-4057qib7 13852 9 due due IN cord-005453-4057qib7 13852 10 to to IN cord-005453-4057qib7 13852 11 progressive progressive JJ cord-005453-4057qib7 13852 12 disease disease NN cord-005453-4057qib7 13852 13 . . . cord-005453-4057qib7 13853 1 Conclusions conclusion NNS cord-005453-4057qib7 13853 2 : : : cord-005453-4057qib7 13854 1 In in IN cord-005453-4057qib7 13854 2 our -PRON- PRP$ cord-005453-4057qib7 13854 3 study study NN cord-005453-4057qib7 13854 4 , , , cord-005453-4057qib7 13854 5 tandem tandem JJ cord-005453-4057qib7 13854 6 HSCT HSCT NNP cord-005453-4057qib7 13854 7 in in IN cord-005453-4057qib7 13854 8 children child NNS cord-005453-4057qib7 13854 9 with with IN cord-005453-4057qib7 13854 10 solid solid JJ cord-005453-4057qib7 13854 11 tumours tumour NNS cord-005453-4057qib7 13854 12 lead lead VBP cord-005453-4057qib7 13854 13 to to IN cord-005453-4057qib7 13854 14 an an DT cord-005453-4057qib7 13854 15 increase increase NN cord-005453-4057qib7 13854 16 in in IN cord-005453-4057qib7 13854 17 survival survival NN cord-005453-4057qib7 13854 18 rates rate NNS cord-005453-4057qib7 13854 19 , , , cord-005453-4057qib7 13854 20 at at IN cord-005453-4057qib7 13854 21 least least JJS cord-005453-4057qib7 13854 22 in in IN cord-005453-4057qib7 13854 23 the the DT cord-005453-4057qib7 13854 24 first first JJ cord-005453-4057qib7 13854 25 6 6 CD cord-005453-4057qib7 13854 26 months month NNS cord-005453-4057qib7 13854 27 after after IN cord-005453-4057qib7 13854 28 SCT SCT NNP cord-005453-4057qib7 13854 29 . . . cord-005453-4057qib7 13855 1 Most Most JJS cord-005453-4057qib7 13855 2 patients patient NNS cord-005453-4057qib7 13855 3 ( ( -LRB- cord-005453-4057qib7 13855 4 90 90 CD cord-005453-4057qib7 13855 5 % % NN cord-005453-4057qib7 13855 6 ) ) -RRB- cord-005453-4057qib7 13855 7 had have VBD cord-005453-4057qib7 13855 8 progressive progressive JJ cord-005453-4057qib7 13855 9 or or CC cord-005453-4057qib7 13855 10 relapsed relapsed JJ cord-005453-4057qib7 13855 11 / / SYM cord-005453-4057qib7 13855 12 refractory refractory JJ cord-005453-4057qib7 13855 13 disease disease NN cord-005453-4057qib7 13855 14 when when WRB cord-005453-4057qib7 13855 15 referred refer VBD cord-005453-4057qib7 13855 16 to to IN cord-005453-4057qib7 13855 17 our -PRON- PRP$ cord-005453-4057qib7 13855 18 department department NN cord-005453-4057qib7 13855 19 . . . cord-005453-4057qib7 13856 1 Multiple multiple JJ cord-005453-4057qib7 13856 2 procedures procedure NNS cord-005453-4057qib7 13856 3 require require VBP cord-005453-4057qib7 13856 4 a a DT cord-005453-4057qib7 13856 5 higher high JJR cord-005453-4057qib7 13856 6 number number NN cord-005453-4057qib7 13856 7 of of IN cord-005453-4057qib7 13856 8 CD34 CD34 NNP cord-005453-4057qib7 13856 9 cells cell NNS cord-005453-4057qib7 13856 10 , , , cord-005453-4057qib7 13856 11 very very RB cord-005453-4057qib7 13856 12 hard hard JJ cord-005453-4057qib7 13856 13 to to TO cord-005453-4057qib7 13856 14 achieve achieve VB cord-005453-4057qib7 13856 15 in in IN cord-005453-4057qib7 13856 16 patients patient NNS cord-005453-4057qib7 13856 17 with with IN cord-005453-4057qib7 13856 18 multiple multiple JJ cord-005453-4057qib7 13856 19 courses course NNS cord-005453-4057qib7 13856 20 of of IN cord-005453-4057qib7 13856 21 chemo± chemo± NNP cord-005453-4057qib7 13856 22 radiotherapy radiotherapy NN cord-005453-4057qib7 13856 23 . . . cord-005453-4057qib7 13857 1 New new JJ cord-005453-4057qib7 13857 2 approaches approach NNS cord-005453-4057qib7 13857 3 have have VBP cord-005453-4057qib7 13857 4 to to TO cord-005453-4057qib7 13857 5 be be VB cord-005453-4057qib7 13857 6 considered consider VBN cord-005453-4057qib7 13857 7 in in IN cord-005453-4057qib7 13857 8 these these DT cord-005453-4057qib7 13857 9 diseases disease NNS cord-005453-4057qib7 13857 10 , , , cord-005453-4057qib7 13857 11 especially especially RB cord-005453-4057qib7 13857 12 in in IN cord-005453-4057qib7 13857 13 high high JJ cord-005453-4057qib7 13857 14 risk risk NN cord-005453-4057qib7 13857 15 group group NN cord-005453-4057qib7 13857 16 . . . cord-005453-4057qib7 13858 1 Disclosure disclosure NN cord-005453-4057qib7 13858 2 : : : cord-005453-4057qib7 13858 3 Nothing nothing NN cord-005453-4057qib7 13858 4 to to TO cord-005453-4057qib7 13858 5 declare declare VB cord-005453-4057qib7 13858 6 Background background NN cord-005453-4057qib7 13858 7 : : : cord-005453-4057qib7 13858 8 Antimicrobial antimicrobial JJ cord-005453-4057qib7 13858 9 prophylaxis prophylaxis NN cord-005453-4057qib7 13858 10 for for IN cord-005453-4057qib7 13858 11 prolonged prolonged JJ cord-005453-4057qib7 13858 12 neutropenia neutropenia NN cord-005453-4057qib7 13858 13 occurred occur VBD cord-005453-4057qib7 13858 14 during during IN cord-005453-4057qib7 13858 15 the the DT cord-005453-4057qib7 13858 16 pre pre JJ cord-005453-4057qib7 13858 17 - - JJ cord-005453-4057qib7 13858 18 engraftment engraftment JJ cord-005453-4057qib7 13858 19 period period NN cord-005453-4057qib7 13858 20 is be VBZ cord-005453-4057qib7 13858 21 a a DT cord-005453-4057qib7 13858 22 common common JJ cord-005453-4057qib7 13858 23 practice practice NN cord-005453-4057qib7 13858 24 in in IN cord-005453-4057qib7 13858 25 allogeneic allogeneic JJ cord-005453-4057qib7 13858 26 HSCT HSCT NNP cord-005453-4057qib7 13858 27 recipients recipient NNS cord-005453-4057qib7 13858 28 . . . cord-005453-4057qib7 13859 1 Data datum NNS cord-005453-4057qib7 13859 2 on on IN cord-005453-4057qib7 13859 3 its -PRON- PRP$ cord-005453-4057qib7 13859 4 effectiveness effectiveness NN cord-005453-4057qib7 13859 5 are be VBP cord-005453-4057qib7 13859 6 few few JJ cord-005453-4057qib7 13859 7 and and CC cord-005453-4057qib7 13859 8 generally generally RB cord-005453-4057qib7 13859 9 from from IN cord-005453-4057qib7 13859 10 cases case NNS cord-005453-4057qib7 13859 11 series series NN cord-005453-4057qib7 13859 12 and and CC cord-005453-4057qib7 13859 13 not not RB cord-005453-4057qib7 13859 14 from from IN cord-005453-4057qib7 13859 15 randomized randomized JJ cord-005453-4057qib7 13859 16 clinical clinical JJ cord-005453-4057qib7 13859 17 trials trial NNS cord-005453-4057qib7 13859 18 , , , cord-005453-4057qib7 13859 19 especially especially RB cord-005453-4057qib7 13859 20 in in IN cord-005453-4057qib7 13859 21 children child NNS cord-005453-4057qib7 13859 22 . . . cord-005453-4057qib7 13860 1 Methods method NNS cord-005453-4057qib7 13860 2 : : : cord-005453-4057qib7 13861 1 All all DT cord-005453-4057qib7 13861 2 clinical clinical JJ cord-005453-4057qib7 13861 3 records record NNS cord-005453-4057qib7 13861 4 of of IN cord-005453-4057qib7 13861 5 allo allo NN cord-005453-4057qib7 13861 6 - - HYPH cord-005453-4057qib7 13861 7 HSCT HSCT NNP cord-005453-4057qib7 13861 8 performed perform VBD cord-005453-4057qib7 13861 9 from from IN cord-005453-4057qib7 13861 10 January January NNP cord-005453-4057qib7 13861 11 1 1 CD cord-005453-4057qib7 13861 12 st st NNP cord-005453-4057qib7 13861 13 2007 2007 CD cord-005453-4057qib7 13861 14 to to IN cord-005453-4057qib7 13861 15 November November NNP cord-005453-4057qib7 13861 16 30 30 CD cord-005453-4057qib7 13861 17 th th CD cord-005453-4057qib7 13861 18 2018 2018 CD cord-005453-4057qib7 13861 19 at at IN cord-005453-4057qib7 13861 20 HSCT HSCT NNP cord-005453-4057qib7 13861 21 - - HYPH cord-005453-4057qib7 13861 22 Unit Unit NNP cord-005453-4057qib7 13861 23 of of IN cord-005453-4057qib7 13861 24 Istituto Istituto NNP cord-005453-4057qib7 13861 25 G.Gaslini G.Gaslini NNP cord-005453-4057qib7 13861 26 , , , cord-005453-4057qib7 13861 27 Genoa Genoa NNP cord-005453-4057qib7 13861 28 - - HYPH cord-005453-4057qib7 13861 29 Italy Italy NNP cord-005453-4057qib7 13861 30 , , , cord-005453-4057qib7 13861 31 were be VBD cord-005453-4057qib7 13861 32 retrospectively retrospectively RB cord-005453-4057qib7 13861 33 reviewed review VBN cord-005453-4057qib7 13861 34 . . . cord-005453-4057qib7 13862 1 Collected collect VBN cord-005453-4057qib7 13862 2 data datum NNS cord-005453-4057qib7 13862 3 were be VBD cord-005453-4057qib7 13862 4 underlying underlie VBG cord-005453-4057qib7 13862 5 diseases disease NNS cord-005453-4057qib7 13862 6 , , , cord-005453-4057qib7 13862 7 type type NN cord-005453-4057qib7 13862 8 of of IN cord-005453-4057qib7 13862 9 donor donor NN cord-005453-4057qib7 13862 10 , , , cord-005453-4057qib7 13862 11 antibiotic antibiotic JJ cord-005453-4057qib7 13862 12 prophylaxis prophylaxis NN cord-005453-4057qib7 13862 13 administration administration NN cord-005453-4057qib7 13862 14 and and CC cord-005453-4057qib7 13862 15 type type NN cord-005453-4057qib7 13862 16 , , , cord-005453-4057qib7 13862 17 development development NN cord-005453-4057qib7 13862 18 of of IN cord-005453-4057qib7 13862 19 fever fever NN cord-005453-4057qib7 13862 20 and and CC cord-005453-4057qib7 13862 21 pathogen pathogen NN cord-005453-4057qib7 13862 22 isolated isolate VBN cord-005453-4057qib7 13862 23 from from IN cord-005453-4057qib7 13862 24 blood blood NN cord-005453-4057qib7 13862 25 culture culture NN cord-005453-4057qib7 13862 26 , , , cord-005453-4057qib7 13862 27 if if IN cord-005453-4057qib7 13862 28 any any DT cord-005453-4057qib7 13862 29 , , , cord-005453-4057qib7 13862 30 during during IN cord-005453-4057qib7 13862 31 pre pre JJ cord-005453-4057qib7 13862 32 - - JJ cord-005453-4057qib7 13862 33 engraftment engraftment JJ cord-005453-4057qib7 13862 34 neutropenia neutropenia NN cord-005453-4057qib7 13862 35 . . . cord-005453-4057qib7 13863 1 Antibiotic antibiotic JJ cord-005453-4057qib7 13863 2 prophylaxis prophylaxis NN cord-005453-4057qib7 13863 3 , , , cord-005453-4057qib7 13863 4 usually usually RB cord-005453-4057qib7 13863 5 starting start VBG cord-005453-4057qib7 13863 6 together together RB cord-005453-4057qib7 13863 7 with with IN cord-005453-4057qib7 13863 8 the the DT cord-005453-4057qib7 13863 9 conditioning conditioning NN cord-005453-4057qib7 13863 10 regimen regimen NN cord-005453-4057qib7 13863 11 , , , cord-005453-4057qib7 13863 12 was be VBD cord-005453-4057qib7 13863 13 categorized categorize VBN cord-005453-4057qib7 13863 14 in in IN cord-005453-4057qib7 13863 15 " " `` cord-005453-4057qib7 13863 16 standard standard JJ cord-005453-4057qib7 13863 17 " " '' cord-005453-4057qib7 13863 18 ( ( -LRB- cord-005453-4057qib7 13863 19 with with IN cord-005453-4057qib7 13863 20 amoxicillin amoxicillin NNP cord-005453-4057qib7 13863 21 / / SYM cord-005453-4057qib7 13863 22 clavulanate clavulanate NNP cord-005453-4057qib7 13863 23 or or CC cord-005453-4057qib7 13863 24 ampicillin ampicillin NNP cord-005453-4057qib7 13863 25 / / SYM cord-005453-4057qib7 13863 26 sulbactam sulbactam NNP cord-005453-4057qib7 13863 27 ) ) -RRB- cord-005453-4057qib7 13863 28 or or CC cord-005453-4057qib7 13863 29 " " `` cord-005453-4057qib7 13863 30 tailored tailor VBN cord-005453-4057qib7 13863 31 " " '' cord-005453-4057qib7 13863 32 ( ( -LRB- cord-005453-4057qib7 13863 33 when when WRB cord-005453-4057qib7 13863 34 based base VBN cord-005453-4057qib7 13863 35 on on IN cord-005453-4057qib7 13863 36 previous previous JJ cord-005453-4057qib7 13863 37 bacterial bacterial JJ cord-005453-4057qib7 13863 38 isolations isolation NNS cord-005453-4057qib7 13863 39 or or CC cord-005453-4057qib7 13863 40 colonizations colonization NNS cord-005453-4057qib7 13863 41 ) ) -RRB- cord-005453-4057qib7 13863 42 . . . cord-005453-4057qib7 13864 1 Results result NNS cord-005453-4057qib7 13864 2 : : : cord-005453-4057qib7 13865 1 246 246 CD cord-005453-4057qib7 13865 2 allo allo NN cord-005453-4057qib7 13865 3 - - HYPH cord-005453-4057qib7 13865 4 HSCTs hsct NNS cord-005453-4057qib7 13865 5 were be VBD cord-005453-4057qib7 13865 6 performed perform VBN cord-005453-4057qib7 13865 7 in in IN cord-005453-4057qib7 13865 8 217 217 CD cord-005453-4057qib7 13865 9 pediatric pediatric JJ cord-005453-4057qib7 13865 10 patients patient NNS cord-005453-4057qib7 13865 11 ( ( -LRB- cord-005453-4057qib7 13865 12 59 59 CD cord-005453-4057qib7 13865 13 % % NN cord-005453-4057qib7 13865 14 males male NNS cord-005453-4057qib7 13865 15 ) ) -RRB- cord-005453-4057qib7 13865 16 with with IN cord-005453-4057qib7 13865 17 a a DT cord-005453-4057qib7 13865 18 median median JJ cord-005453-4057qib7 13865 19 age age NN cord-005453-4057qib7 13865 20 at at IN cord-005453-4057qib7 13865 21 HSCT HSCT NNP cord-005453-4057qib7 13865 22 of of IN cord-005453-4057qib7 13865 23 8 8 CD cord-005453-4057qib7 13865 24 years year NNS cord-005453-4057qib7 13866 1 ( ( -LRB- cord-005453-4057qib7 13866 2 IQR iqr NN cord-005453-4057qib7 13866 3 : : : cord-005453-4057qib7 13866 4 4 4 CD cord-005453-4057qib7 13866 5 - - SYM cord-005453-4057qib7 13866 6 13 13 CD cord-005453-4057qib7 13866 7 ; ; . cord-005453-4057qib7 13867 1 range range NN cord-005453-4057qib7 13867 2 : : : cord-005453-4057qib7 13867 3 0 0 CD cord-005453-4057qib7 13867 4 - - SYM cord-005453-4057qib7 13867 5 22 22 CD cord-005453-4057qib7 13867 6 ) ) -RRB- cord-005453-4057qib7 13867 7 . . . cord-005453-4057qib7 13868 1 HSCTs hsct NNS cord-005453-4057qib7 13868 2 were be VBD cord-005453-4057qib7 13868 3 performed perform VBN cord-005453-4057qib7 13868 4 from from IN cord-005453-4057qib7 13868 5 alternative alternative JJ cord-005453-4057qib7 13868 6 donor donor NN cord-005453-4057qib7 13868 7 ( ( -LRB- cord-005453-4057qib7 13868 8 AD ad NN cord-005453-4057qib7 13868 9 ) ) -RRB- cord-005453-4057qib7 13868 10 in in IN cord-005453-4057qib7 13868 11 55 55 CD cord-005453-4057qib7 13868 12 % % NN cord-005453-4057qib7 13868 13 patients patient NNS cord-005453-4057qib7 13868 14 , , , cord-005453-4057qib7 13868 15 from from IN cord-005453-4057qib7 13868 16 relative relative JJ cord-005453-4057qib7 13868 17 donor donor NN cord-005453-4057qib7 13868 18 ( ( -LRB- cord-005453-4057qib7 13868 19 RD RD NNP cord-005453-4057qib7 13868 20 ) ) -RRB- cord-005453-4057qib7 13868 21 in in IN cord-005453-4057qib7 13868 22 25 25 CD cord-005453-4057qib7 13868 23 % % NN cord-005453-4057qib7 13868 24 , , , cord-005453-4057qib7 13868 25 and and CC cord-005453-4057qib7 13868 26 from from IN cord-005453-4057qib7 13868 27 haploidentical haploidentical JJ cord-005453-4057qib7 13868 28 donor donor NN cord-005453-4057qib7 13868 29 in in IN cord-005453-4057qib7 13868 30 20 20 CD cord-005453-4057qib7 13868 31 % % NN cord-005453-4057qib7 13868 32 . . . cord-005453-4057qib7 13869 1 Table table NN cord-005453-4057qib7 13869 2 1 1 CD cord-005453-4057qib7 13869 3 shows show VBZ cord-005453-4057qib7 13869 4 the the DT cord-005453-4057qib7 13869 5 pre pre JJ cord-005453-4057qib7 13869 6 - - JJ cord-005453-4057qib7 13869 7 engraftment engraftment JJ cord-005453-4057qib7 13869 8 febrile febrile JJ cord-005453-4057qib7 13869 9 neutropenia neutropenia NN cord-005453-4057qib7 13869 10 episodes episode NNS cord-005453-4057qib7 13869 11 according accord VBG cord-005453-4057qib7 13869 12 to to IN cord-005453-4057qib7 13869 13 type type NN cord-005453-4057qib7 13869 14 of of IN cord-005453-4057qib7 13869 15 antibiotic antibiotic JJ cord-005453-4057qib7 13869 16 prophylaxis prophylaxis NN cord-005453-4057qib7 13869 17 . . . cord-005453-4057qib7 13870 1 224 224 CD cord-005453-4057qib7 13870 2 ( ( -LRB- cord-005453-4057qib7 13870 3 91 91 CD cord-005453-4057qib7 13870 4 % % NN cord-005453-4057qib7 13870 5 ) ) -RRB- cord-005453-4057qib7 13871 1 HSCTs hsct NNS cord-005453-4057qib7 13871 2 received receive VBD cord-005453-4057qib7 13871 3 standard standard JJ cord-005453-4057qib7 13871 4 prophylaxis prophylaxis NN cord-005453-4057qib7 13871 5 , , , cord-005453-4057qib7 13871 6 while while IN cord-005453-4057qib7 13871 7 20 20 CD cord-005453-4057qib7 13871 8 ( ( -LRB- cord-005453-4057qib7 13871 9 8 8 CD cord-005453-4057qib7 13871 10 % % NN cord-005453-4057qib7 13871 11 ) ) -RRB- cord-005453-4057qib7 13871 12 the the DT cord-005453-4057qib7 13871 13 tailored tailor VBN cord-005453-4057qib7 13871 14 one one NN cord-005453-4057qib7 13871 15 ; ; : cord-005453-4057qib7 13871 16 only only RB cord-005453-4057qib7 13871 17 in in IN cord-005453-4057qib7 13871 18 2 2 CD cord-005453-4057qib7 13871 19 ( ( -LRB- cord-005453-4057qib7 13871 20 1 1 CD cord-005453-4057qib7 13871 21 % % NN cord-005453-4057qib7 13871 22 ) ) -RRB- cord-005453-4057qib7 13871 23 did do VBD cord-005453-4057qib7 13871 24 not not RB cord-005453-4057qib7 13871 25 receive receive VB cord-005453-4057qib7 13871 26 any any DT cord-005453-4057qib7 13871 27 prophylaxis prophylaxis NN cord-005453-4057qib7 13871 28 . . . cord-005453-4057qib7 13872 1 Fever fever NN cord-005453-4057qib7 13872 2 occurred occur VBD cord-005453-4057qib7 13872 3 in in IN cord-005453-4057qib7 13872 4 194 194 CD cord-005453-4057qib7 13872 5 ( ( -LRB- cord-005453-4057qib7 13872 6 87 87 CD cord-005453-4057qib7 13872 7 % % NN cord-005453-4057qib7 13872 8 ) ) -RRB- cord-005453-4057qib7 13872 9 of of IN cord-005453-4057qib7 13872 10 episodes episode NNS cord-005453-4057qib7 13872 11 in in IN cord-005453-4057qib7 13872 12 patients patient NNS cord-005453-4057qib7 13872 13 receiving receive VBG cord-005453-4057qib7 13872 14 standard standard JJ cord-005453-4057qib7 13872 15 prophylaxis prophylaxis NN cord-005453-4057qib7 13872 16 , , , cord-005453-4057qib7 13872 17 in in IN cord-005453-4057qib7 13872 18 19 19 CD cord-005453-4057qib7 13872 19 ( ( -LRB- cord-005453-4057qib7 13872 20 95 95 CD cord-005453-4057qib7 13872 21 % % NN cord-005453-4057qib7 13872 22 ) ) -RRB- cord-005453-4057qib7 13872 23 of of IN cord-005453-4057qib7 13872 24 those those DT cord-005453-4057qib7 13872 25 treated treat VBN cord-005453-4057qib7 13872 26 with with IN cord-005453-4057qib7 13872 27 tailored tailor VBN cord-005453-4057qib7 13872 28 prophylaxis prophylaxis NN cord-005453-4057qib7 13872 29 and and CC cord-005453-4057qib7 13872 30 1 1 CD cord-005453-4057qib7 13872 31 ( ( -LRB- cord-005453-4057qib7 13872 32 50 50 CD cord-005453-4057qib7 13872 33 % % NN cord-005453-4057qib7 13872 34 ) ) -RRB- cord-005453-4057qib7 13872 35 in in IN cord-005453-4057qib7 13872 36 the the DT cord-005453-4057qib7 13872 37 group group NN cord-005453-4057qib7 13872 38 without without IN cord-005453-4057qib7 13872 39 prophylaxis prophylaxis NN cord-005453-4057qib7 13872 40 ; ; : cord-005453-4057qib7 13872 41 only only RB cord-005453-4057qib7 13872 42 13 13 CD cord-005453-4057qib7 13872 43 % % NN cord-005453-4057qib7 13872 44 of of IN cord-005453-4057qib7 13872 45 patients patient NNS cord-005453-4057qib7 13872 46 who who WP cord-005453-4057qib7 13872 47 received receive VBD cord-005453-4057qib7 13872 48 prophylaxis prophylaxis NN cord-005453-4057qib7 13872 49 did do VBD cord-005453-4057qib7 13872 50 not not RB cord-005453-4057qib7 13872 51 develop develop VB cord-005453-4057qib7 13872 52 fever fever NN cord-005453-4057qib7 13872 53 . . . cord-005453-4057qib7 13873 1 In in IN cord-005453-4057qib7 13873 2 38 38 CD cord-005453-4057qib7 13873 3 % % NN cord-005453-4057qib7 13873 4 of of IN cord-005453-4057qib7 13873 5 patients patient NNS cord-005453-4057qib7 13873 6 , , , cord-005453-4057qib7 13873 7 the the DT cord-005453-4057qib7 13873 8 febrile febrile JJ cord-005453-4057qib7 13873 9 episodes episode NNS cord-005453-4057qib7 13873 10 were be VBD cord-005453-4057qib7 13873 11 diagnosed diagnose VBN cord-005453-4057qib7 13873 12 as as IN cord-005453-4057qib7 13873 13 bloodstream bloodstream NN cord-005453-4057qib7 13873 14 infections infection NNS cord-005453-4057qib7 13873 15 : : : cord-005453-4057qib7 13873 16 Staphylococcus staphylococcus NN cord-005453-4057qib7 13873 17 aureus aureus NN cord-005453-4057qib7 13873 18 in in IN cord-005453-4057qib7 13873 19 2 2 CD cord-005453-4057qib7 13873 20 % % NN cord-005453-4057qib7 13873 21 ; ; : cord-005453-4057qib7 13873 22 CoNS CoNS NNP cord-005453-4057qib7 13873 23 in in IN cord-005453-4057qib7 13873 24 19 19 CD cord-005453-4057qib7 13873 25 % % NN cord-005453-4057qib7 13873 26 ; ; : cord-005453-4057qib7 13873 27 Enterococcus Enterococcus NNP cord-005453-4057qib7 13873 28 spp spp NNS cord-005453-4057qib7 13873 29 in in IN cord-005453-4057qib7 13873 30 15 15 CD cord-005453-4057qib7 13873 31 % % NN cord-005453-4057qib7 13873 32 ; ; . cord-005453-4057qib7 13874 1 Enterobacteriaceae Enterobacteriaceae NNP cord-005453-4057qib7 13874 2 in in IN cord-005453-4057qib7 13874 3 25 25 CD cord-005453-4057qib7 13874 4 % % NN cord-005453-4057qib7 13874 5 ; ; : cord-005453-4057qib7 13874 6 Pseudomonas Pseudomonas NNP cord-005453-4057qib7 13874 7 aeruginosa aeruginosa NN cord-005453-4057qib7 13874 8 in in IN cord-005453-4057qib7 13874 9 11 11 CD cord-005453-4057qib7 13874 10 % % NN cord-005453-4057qib7 13874 11 ; ; , cord-005453-4057qib7 13874 12 other other JJ cord-005453-4057qib7 13874 13 non non JJ cord-005453-4057qib7 13874 14 - - JJ cord-005453-4057qib7 13874 15 fermenting fermenting JJ cord-005453-4057qib7 13874 16 gram gram NN cord-005453-4057qib7 13874 17 negatives negative NNS cord-005453-4057qib7 13874 18 in in IN cord-005453-4057qib7 13874 19 2 2 CD cord-005453-4057qib7 13874 20 % % NN cord-005453-4057qib7 13874 21 and and CC cord-005453-4057qib7 13874 22 fungi fungus NNS cord-005453-4057qib7 13874 23 in10 in10 IN cord-005453-4057qib7 13874 24 % % NN cord-005453-4057qib7 13874 25 . . . cord-005453-4057qib7 13875 1 Conclusions conclusion NNS cord-005453-4057qib7 13875 2 : : : cord-005453-4057qib7 13876 1 The the DT cord-005453-4057qib7 13876 2 occurrence occurrence NN cord-005453-4057qib7 13876 3 of of IN cord-005453-4057qib7 13876 4 fever fever NN cord-005453-4057qib7 13876 5 in in IN cord-005453-4057qib7 13876 6 patients patient NNS cord-005453-4057qib7 13876 7 who who WP cord-005453-4057qib7 13876 8 received receive VBD cord-005453-4057qib7 13876 9 antibiotic antibiotic JJ cord-005453-4057qib7 13876 10 prophylaxis prophylaxis NN cord-005453-4057qib7 13876 11 suggested suggest VBD cord-005453-4057qib7 13876 12 that that IN cord-005453-4057qib7 13876 13 it -PRON- PRP cord-005453-4057qib7 13876 14 could could MD cord-005453-4057qib7 13876 15 not not RB cord-005453-4057qib7 13876 16 be be VB cord-005453-4057qib7 13876 17 effective effective JJ cord-005453-4057qib7 13876 18 in in IN cord-005453-4057qib7 13876 19 prevention prevention NN cord-005453-4057qib7 13876 20 of of IN cord-005453-4057qib7 13876 21 fever fever NN cord-005453-4057qib7 13876 22 related relate VBN cord-005453-4057qib7 13876 23 to to IN cord-005453-4057qib7 13876 24 neutropenia neutropenia NN cord-005453-4057qib7 13876 25 after after IN cord-005453-4057qib7 13876 26 allo allo NN cord-005453-4057qib7 13876 27 - - HYPH cord-005453-4057qib7 13876 28 HSCT HSCT NNP cord-005453-4057qib7 13876 29 . . . cord-005453-4057qib7 13877 1 The the DT cord-005453-4057qib7 13877 2 personalization personalization NN cord-005453-4057qib7 13877 3 of of IN cord-005453-4057qib7 13877 4 prophylaxis prophylaxis NN cord-005453-4057qib7 13877 5 could could MD cord-005453-4057qib7 13877 6 be be VB cord-005453-4057qib7 13877 7 a a DT cord-005453-4057qib7 13877 8 possible possible JJ cord-005453-4057qib7 13877 9 path path NN cord-005453-4057qib7 13877 10 to to TO cord-005453-4057qib7 13877 11 follow follow VB cord-005453-4057qib7 13877 12 these these DT cord-005453-4057qib7 13877 13 patients patient NNS cord-005453-4057qib7 13877 14 . . . cord-005453-4057qib7 13878 1 Disclosure disclosure NN cord-005453-4057qib7 13878 2 Methods method NNS cord-005453-4057qib7 13878 3 : : : cord-005453-4057qib7 13879 1 A a DT cord-005453-4057qib7 13879 2 total total NN cord-005453-4057qib7 13879 3 of of IN cord-005453-4057qib7 13879 4 15 15 CD cord-005453-4057qib7 13879 5 patients patient NNS cord-005453-4057qib7 13879 6 with with IN cord-005453-4057qib7 13879 7 leukemia leukemia NN cord-005453-4057qib7 13879 8 or or CC cord-005453-4057qib7 13879 9 neuroblastoma neuroblastoma NN cord-005453-4057qib7 13879 10 were be VBD cord-005453-4057qib7 13879 11 included include VBN cord-005453-4057qib7 13879 12 in in IN cord-005453-4057qib7 13879 13 the the DT cord-005453-4057qib7 13879 14 study study NN cord-005453-4057qib7 13879 15 . . . cord-005453-4057qib7 13880 1 Patients patient NNS cord-005453-4057qib7 13880 2 ' ' POS cord-005453-4057qib7 13880 3 mothers mother NNS cord-005453-4057qib7 13880 4 signed sign VBD cord-005453-4057qib7 13880 5 an an DT cord-005453-4057qib7 13880 6 informed informed JJ cord-005453-4057qib7 13880 7 consent consent NN cord-005453-4057qib7 13880 8 for for IN cord-005453-4057qib7 13880 9 participation participation NN cord-005453-4057qib7 13880 10 in in IN cord-005453-4057qib7 13880 11 the the DT cord-005453-4057qib7 13880 12 study study NN cord-005453-4057qib7 13880 13 . . . cord-005453-4057qib7 13881 1 Six six CD cord-005453-4057qib7 13881 2 of of IN cord-005453-4057qib7 13881 3 study study NN cord-005453-4057qib7 13881 4 participants participant NNS cord-005453-4057qib7 13881 5 were be VBD cord-005453-4057qib7 13881 6 boys boy NNS cord-005453-4057qib7 13881 7 and and CC cord-005453-4057qib7 13881 8 9 9 CD cord-005453-4057qib7 13881 9 girls girl NNS cord-005453-4057qib7 13881 10 , , , cord-005453-4057qib7 13881 11 all all DT cord-005453-4057qib7 13881 12 aged age VBN cord-005453-4057qib7 13881 13 3 3 CD cord-005453-4057qib7 13881 14 to to TO cord-005453-4057qib7 13881 15 6 6 CD cord-005453-4057qib7 13881 16 years year NNS cord-005453-4057qib7 13881 17 . . . cord-005453-4057qib7 13882 1 The the DT cord-005453-4057qib7 13882 2 control control NN cord-005453-4057qib7 13882 3 group group NN cord-005453-4057qib7 13882 4 consisted consist VBD cord-005453-4057qib7 13882 5 of of IN cord-005453-4057qib7 13882 6 18 18 CD cord-005453-4057qib7 13882 7 healthy healthy JJ cord-005453-4057qib7 13882 8 preschool preschool NN cord-005453-4057qib7 13882 9 children child NNS cord-005453-4057qib7 13882 10 ( ( -LRB- cord-005453-4057qib7 13882 11 2 2 CD cord-005453-4057qib7 13882 12 groups group NNS cord-005453-4057qib7 13882 13 of of IN cord-005453-4057qib7 13882 14 9 9 CD cord-005453-4057qib7 13882 15 children child NNS cord-005453-4057qib7 13882 16 aged age VBN cord-005453-4057qib7 13882 17 5 5 CD cord-005453-4057qib7 13882 18 to to TO cord-005453-4057qib7 13882 19 6 6 CD cord-005453-4057qib7 13882 20 years year NNS cord-005453-4057qib7 13882 21 ) ) -RRB- cord-005453-4057qib7 13882 22 , , , cord-005453-4057qib7 13882 23 8 8 CD cord-005453-4057qib7 13882 24 boys boy NNS cord-005453-4057qib7 13882 25 and and CC cord-005453-4057qib7 13882 26 10 10 CD cord-005453-4057qib7 13882 27 girls girl NNS cord-005453-4057qib7 13882 28 . . . cord-005453-4057qib7 13883 1 Results result NNS cord-005453-4057qib7 13883 2 : : : cord-005453-4057qib7 13884 1 In in IN cord-005453-4057qib7 13884 2 most most JJS cord-005453-4057qib7 13884 3 of of IN cord-005453-4057qib7 13884 4 games game NNS cord-005453-4057qib7 13884 5 the the DT cord-005453-4057qib7 13884 6 role role NN cord-005453-4057qib7 13884 7 of of IN cord-005453-4057qib7 13884 8 a a DT cord-005453-4057qib7 13884 9 doctor doctor NN cord-005453-4057qib7 13884 10 was be VBD cord-005453-4057qib7 13884 11 played play VBN cord-005453-4057qib7 13884 12 by by IN cord-005453-4057qib7 13884 13 a a DT cord-005453-4057qib7 13884 14 child child NN cord-005453-4057qib7 13884 15 . . . cord-005453-4057qib7 13885 1 Only only RB cord-005453-4057qib7 13885 2 one one CD cord-005453-4057qib7 13885 3 child child NN cord-005453-4057qib7 13885 4 declined decline VBD cord-005453-4057qib7 13885 5 to to TO cord-005453-4057qib7 13885 6 impersonate impersonate VB cord-005453-4057qib7 13885 7 both both CC cord-005453-4057qib7 13885 8 a a DT cord-005453-4057qib7 13885 9 patient patient NN cord-005453-4057qib7 13885 10 and and CC cord-005453-4057qib7 13885 11 a a DT cord-005453-4057qib7 13885 12 doctor doctor NN cord-005453-4057qib7 13885 13 . . . cord-005453-4057qib7 13886 1 Younger young JJR cord-005453-4057qib7 13886 2 children child NNS cord-005453-4057qib7 13886 3 mostly mostly RB cord-005453-4057qib7 13886 4 agreed agree VBD cord-005453-4057qib7 13886 5 to to TO cord-005453-4057qib7 13886 6 have have VB cord-005453-4057qib7 13886 7 for for IN cord-005453-4057qib7 13886 8 a a DT cord-005453-4057qib7 13886 9 " " `` cord-005453-4057qib7 13886 10 patient patient JJ cord-005453-4057qib7 13886 11 " " '' cord-005453-4057qib7 13886 12 a a DT cord-005453-4057qib7 13886 13 toy toy NN cord-005453-4057qib7 13886 14 ( ( -LRB- cord-005453-4057qib7 13886 15 proposed propose VBN cord-005453-4057qib7 13886 16 by by IN cord-005453-4057qib7 13886 17 psychologist psychologist NN cord-005453-4057qib7 13886 18 or or CC cord-005453-4057qib7 13886 19 one one CD cord-005453-4057qib7 13886 20 of of IN cord-005453-4057qib7 13886 21 child child NN cord-005453-4057qib7 13886 22 's 's POS cord-005453-4057qib7 13886 23 own own JJ cord-005453-4057qib7 13886 24 ) ) -RRB- cord-005453-4057qib7 13886 25 , , , cord-005453-4057qib7 13886 26 child child NN cord-005453-4057qib7 13886 27 's 's POS cord-005453-4057qib7 13886 28 mother mother NN cord-005453-4057qib7 13886 29 or or CC cord-005453-4057qib7 13886 30 a a DT cord-005453-4057qib7 13886 31 medical medical JJ cord-005453-4057qib7 13886 32 psychologist psychologist NN cord-005453-4057qib7 13886 33 . . . cord-005453-4057qib7 13887 1 The the DT cord-005453-4057qib7 13887 2 game game NN cord-005453-4057qib7 13887 3 lasted last VBD cord-005453-4057qib7 13887 4 for for IN cord-005453-4057qib7 13887 5 15 15 CD cord-005453-4057qib7 13887 6 -20 -20 CD cord-005453-4057qib7 13887 7 minutes minute NNS cord-005453-4057qib7 13887 8 . . . cord-005453-4057qib7 13888 1 Most Most JJS cord-005453-4057qib7 13888 2 patients patient NNS cord-005453-4057qib7 13888 3 preferred prefer VBD cord-005453-4057qib7 13888 4 using use VBG cord-005453-4057qib7 13888 5 real real JJ cord-005453-4057qib7 13888 6 medical medical JJ cord-005453-4057qib7 13888 7 consumables consumable NNS cord-005453-4057qib7 13888 8 and and CC cord-005453-4057qib7 13888 9 instruments instrument NNS cord-005453-4057qib7 13888 10 ( ( -LRB- cord-005453-4057qib7 13888 11 syringes syrinx NNS cord-005453-4057qib7 13888 12 , , , cord-005453-4057qib7 13888 13 adhesive adhesive JJ cord-005453-4057qib7 13888 14 tape tape NN cord-005453-4057qib7 13888 15 , , , cord-005453-4057qib7 13888 16 winged winged JJ cord-005453-4057qib7 13888 17 infusion infusion NN cord-005453-4057qib7 13888 18 sets set NNS cord-005453-4057qib7 13888 19 or or CC cord-005453-4057qib7 13888 20 , , , cord-005453-4057qib7 13888 21 more more RBR cord-005453-4057qib7 13888 22 rarely rarely RB cord-005453-4057qib7 13888 23 , , , cord-005453-4057qib7 13888 24 pills pill NNS cord-005453-4057qib7 13888 25 ) ) -RRB- cord-005453-4057qib7 13888 26 . . . cord-005453-4057qib7 13889 1 Most most RBS cord-005453-4057qib7 13889 2 often often RB cord-005453-4057qib7 13889 3 a a DT cord-005453-4057qib7 13889 4 syringe syringe NN cord-005453-4057qib7 13889 5 or or CC cord-005453-4057qib7 13889 6 an an DT cord-005453-4057qib7 13889 7 adhesive adhesive JJ cord-005453-4057qib7 13889 8 tape tape NN cord-005453-4057qib7 13889 9 was be VBD cord-005453-4057qib7 13889 10 chosen choose VBN cord-005453-4057qib7 13889 11 . . . cord-005453-4057qib7 13890 1 As as IN cord-005453-4057qib7 13890 2 known know VBN cord-005453-4057qib7 13890 3 from from IN cord-005453-4057qib7 13890 4 their -PRON- PRP$ cord-005453-4057qib7 13890 5 mothers mother NNS cord-005453-4057qib7 13890 6 , , , cord-005453-4057qib7 13890 7 among among IN cord-005453-4057qib7 13890 8 medical medical JJ cord-005453-4057qib7 13890 9 manipulations manipulation NNS cord-005453-4057qib7 13890 10 most most RBS cord-005453-4057qib7 13890 11 unpleasant unpleasant JJ cord-005453-4057qib7 13890 12 for for IN cord-005453-4057qib7 13890 13 children child NNS cord-005453-4057qib7 13890 14 are be VBP cord-005453-4057qib7 13890 15 injections injection NNS cord-005453-4057qib7 13890 16 and and CC cord-005453-4057qib7 13890 17 changing change VBG cord-005453-4057qib7 13890 18 implanted implant VBN cord-005453-4057qib7 13890 19 catheter catheter NN cord-005453-4057qib7 13890 20 dressing dressing NN cord-005453-4057qib7 13890 21 . . . cord-005453-4057qib7 13891 1 Also also RB cord-005453-4057qib7 13891 2 , , , cord-005453-4057qib7 13891 3 most most RBS cord-005453-4057qib7 13891 4 healthy healthy JJ cord-005453-4057qib7 13891 5 preschool preschool NN cord-005453-4057qib7 13891 6 children child NNS cord-005453-4057qib7 13891 7 preferred prefer VBD cord-005453-4057qib7 13891 8 using use VBG cord-005453-4057qib7 13891 9 real real JJ cord-005453-4057qib7 13891 10 medical medical JJ cord-005453-4057qib7 13891 11 instruments instrument NNS cord-005453-4057qib7 13891 12 over over IN cord-005453-4057qib7 13891 13 toy toy NN cord-005453-4057qib7 13891 14 ones one NNS cord-005453-4057qib7 13891 15 . . . cord-005453-4057qib7 13892 1 Group group NN cord-005453-4057qib7 13892 2 1 1 CD cord-005453-4057qib7 13892 3 more more RBR cord-005453-4057qib7 13892 4 often often RB cord-005453-4057qib7 13892 5 used use VBD cord-005453-4057qib7 13892 6 a a DT cord-005453-4057qib7 13892 7 syringe syringe NN cord-005453-4057qib7 13892 8 , , , cord-005453-4057qib7 13892 9 a a DT cord-005453-4057qib7 13892 10 winged winged JJ cord-005453-4057qib7 13892 11 infusion infusion NN cord-005453-4057qib7 13892 12 set set NN cord-005453-4057qib7 13892 13 , , , cord-005453-4057qib7 13892 14 adhesive adhesive JJ cord-005453-4057qib7 13892 15 tape tape NN cord-005453-4057qib7 13892 16 , , , cord-005453-4057qib7 13892 17 gauze gauze NN cord-005453-4057qib7 13892 18 or or CC cord-005453-4057qib7 13892 19 pills pill NNS cord-005453-4057qib7 13892 20 . . . cord-005453-4057qib7 13893 1 Group group NN cord-005453-4057qib7 13893 2 2 2 CD cord-005453-4057qib7 13893 3 most most RBS cord-005453-4057qib7 13893 4 often often RB cord-005453-4057qib7 13893 5 chose choose VBD cord-005453-4057qib7 13893 6 syringe syringe NN cord-005453-4057qib7 13893 7 or or CC cord-005453-4057qib7 13893 8 gauze gauze NN cord-005453-4057qib7 13893 9 . . . cord-005453-4057qib7 13894 1 Among among IN cord-005453-4057qib7 13894 2 medical medical JJ cord-005453-4057qib7 13894 3 instruments instrument NNS cord-005453-4057qib7 13894 4 both both DT cord-005453-4057qib7 13894 5 groups group NNS cord-005453-4057qib7 13894 6 more more RBR cord-005453-4057qib7 13894 7 often often RB cord-005453-4057qib7 13894 8 chose choose VBD cord-005453-4057qib7 13894 9 a a DT cord-005453-4057qib7 13894 10 phonendoscope phonendoscope NN cord-005453-4057qib7 13894 11 or or CC cord-005453-4057qib7 13894 12 thermometer thermometer NN cord-005453-4057qib7 13894 13 . . . cord-005453-4057qib7 13895 1 One one CD cord-005453-4057qib7 13895 2 patient patient NN cord-005453-4057qib7 13895 3 refused refuse VBD cord-005453-4057qib7 13895 4 to to TO cord-005453-4057qib7 13895 5 cause cause VB cord-005453-4057qib7 13895 6 pain pain NN cord-005453-4057qib7 13895 7 to to IN cord-005453-4057qib7 13895 8 a a DT cord-005453-4057qib7 13895 9 " " `` cord-005453-4057qib7 13895 10 toy toy NN cord-005453-4057qib7 13895 11 patient patient NN cord-005453-4057qib7 13895 12 " " '' cord-005453-4057qib7 13895 13 . . . cord-005453-4057qib7 13896 1 Other other JJ cord-005453-4057qib7 13896 2 children child NNS cord-005453-4057qib7 13896 3 sympathized sympathize VBD cord-005453-4057qib7 13896 4 with with IN cord-005453-4057qib7 13896 5 a a DT cord-005453-4057qib7 13896 6 " " `` cord-005453-4057qib7 13896 7 toy toy NN cord-005453-4057qib7 13896 8 patient patient NN cord-005453-4057qib7 13896 9 " " '' cord-005453-4057qib7 13896 10 , , , cord-005453-4057qib7 13896 11 stroke stroke NN cord-005453-4057qib7 13896 12 injection injection NN cord-005453-4057qib7 13896 13 or or CC cord-005453-4057qib7 13896 14 dressing dress VBG cord-005453-4057qib7 13896 15 location location NN cord-005453-4057qib7 13896 16 sites site NNS cord-005453-4057qib7 13896 17 or or CC cord-005453-4057qib7 13896 18 used use VBN cord-005453-4057qib7 13896 19 soothing soothing JJ cord-005453-4057qib7 13896 20 terms term NNS cord-005453-4057qib7 13896 21 ( ( -LRB- cord-005453-4057qib7 13896 22 " " `` cord-005453-4057qib7 13896 23 wait wait VB cord-005453-4057qib7 13896 24 a a DT cord-005453-4057qib7 13896 25 little little JJ cord-005453-4057qib7 13896 26 " " '' cord-005453-4057qib7 13896 27 , , , cord-005453-4057qib7 13896 28 " " `` cord-005453-4057qib7 13896 29 it -PRON- PRP cord-005453-4057qib7 13896 30 's be VBZ cord-005453-4057qib7 13896 31 going go VBG cord-005453-4057qib7 13896 32 to to TO cord-005453-4057qib7 13896 33 be be VB cord-005453-4057qib7 13896 34 all all RB cord-005453-4057qib7 13896 35 right right JJ cord-005453-4057qib7 13896 36 " " '' cord-005453-4057qib7 13896 37 ) ) -RRB- cord-005453-4057qib7 13896 38 , , , cord-005453-4057qib7 13896 39 wished wish VBD cord-005453-4057qib7 13896 40 prompt prompt JJ cord-005453-4057qib7 13896 41 recovery recovery NN cord-005453-4057qib7 13896 42 and and CC cord-005453-4057qib7 13896 43 hugged hug VBD cord-005453-4057qib7 13896 44 their -PRON- PRP$ cord-005453-4057qib7 13896 45 " " `` cord-005453-4057qib7 13896 46 patients patient NNS cord-005453-4057qib7 13896 47 " " '' cord-005453-4057qib7 13896 48 . . . cord-005453-4057qib7 13897 1 One one CD cord-005453-4057qib7 13897 2 child child NN cord-005453-4057qib7 13897 3 was be VBD cord-005453-4057qib7 13897 4 angry angry JJ cord-005453-4057qib7 13897 5 over over IN cord-005453-4057qib7 13897 6 his -PRON- PRP$ cord-005453-4057qib7 13897 7 " " `` cord-005453-4057qib7 13897 8 patient patient NN cord-005453-4057qib7 13897 9 " " '' cord-005453-4057qib7 13897 10 wishing wish VBG cord-005453-4057qib7 13897 11 him -PRON- PRP cord-005453-4057qib7 13897 12 to to TO cord-005453-4057qib7 13897 13 " " `` cord-005453-4057qib7 13897 14 get get VB cord-005453-4057qib7 13897 15 hurt hurt VBN cord-005453-4057qib7 13897 16 too too RB cord-005453-4057qib7 13897 17 " " '' cord-005453-4057qib7 13897 18 . . . cord-005453-4057qib7 13898 1 First first JJ cord-005453-4057qib7 13898 2 preschool preschool NN cord-005453-4057qib7 13898 3 group group NN cord-005453-4057qib7 13898 4 children child NNS cord-005453-4057qib7 13898 5 were be VBD cord-005453-4057qib7 13898 6 mostly mostly RB cord-005453-4057qib7 13898 7 scolding scold VBG cord-005453-4057qib7 13898 8 a a DT cord-005453-4057qib7 13898 9 toy toy NN cord-005453-4057qib7 13898 10 " " `` cord-005453-4057qib7 13898 11 patient patient NN cord-005453-4057qib7 13898 12 " " '' cord-005453-4057qib7 13898 13 for for IN cord-005453-4057qib7 13898 14 " " `` cord-005453-4057qib7 13898 15 being be VBG cord-005453-4057qib7 13898 16 guilty guilty JJ cord-005453-4057qib7 13898 17 of of IN cord-005453-4057qib7 13898 18 getting get VBG cord-005453-4057qib7 13898 19 sick sick JJ cord-005453-4057qib7 13898 20 " " '' cord-005453-4057qib7 13898 21 . . . cord-005453-4057qib7 13899 1 Second second JJ cord-005453-4057qib7 13899 2 group group NN cord-005453-4057qib7 13899 3 children child NNS cord-005453-4057qib7 13899 4 were be VBD cord-005453-4057qib7 13899 5 mostly mostly RB cord-005453-4057qib7 13899 6 compassionate compassionate JJ cord-005453-4057qib7 13899 7 , , , cord-005453-4057qib7 13899 8 encouraged encourage VBD cord-005453-4057qib7 13899 9 a a DT cord-005453-4057qib7 13899 10 " " `` cord-005453-4057qib7 13899 11 toy toy NN cord-005453-4057qib7 13899 12 patient patient NN cord-005453-4057qib7 13899 13 " " '' cord-005453-4057qib7 13899 14 telling tell VBG cord-005453-4057qib7 13899 15 that that IN cord-005453-4057qib7 13899 16 " " `` cord-005453-4057qib7 13899 17 all all PDT cord-005453-4057qib7 13899 18 the the DT cord-005453-4057qib7 13899 19 procedures procedure NNS cord-005453-4057qib7 13899 20 are be VBP cord-005453-4057qib7 13899 21 needed need VBN cord-005453-4057qib7 13899 22 to to TO cord-005453-4057qib7 13899 23 get get VB cord-005453-4057qib7 13899 24 healthy healthy JJ cord-005453-4057qib7 13899 25 " " '' cord-005453-4057qib7 13899 26 . . . cord-005453-4057qib7 13900 1 From from IN cord-005453-4057qib7 13900 2 children child NNS cord-005453-4057qib7 13900 3 's 's POS cord-005453-4057qib7 13900 4 schoolmasters schoolmaster NNS cord-005453-4057qib7 13900 5 we -PRON- PRP cord-005453-4057qib7 13900 6 know know VBP cord-005453-4057qib7 13900 7 that that IN cord-005453-4057qib7 13900 8 all all DT cord-005453-4057qib7 13900 9 first first JJ cord-005453-4057qib7 13900 10 group group NN cord-005453-4057qib7 13900 11 children child NNS cord-005453-4057qib7 13900 12 received receive VBD cord-005453-4057qib7 13900 13 vaccination vaccination NN cord-005453-4057qib7 13900 14 about about IN cord-005453-4057qib7 13900 15 a a DT cord-005453-4057qib7 13900 16 week week NN cord-005453-4057qib7 13900 17 before before IN cord-005453-4057qib7 13900 18 a a DT cord-005453-4057qib7 13900 19 test test NN cord-005453-4057qib7 13900 20 . . . cord-005453-4057qib7 13901 1 Children child NNS cord-005453-4057qib7 13901 2 from from IN cord-005453-4057qib7 13901 3 second second JJ cord-005453-4057qib7 13901 4 group group NN cord-005453-4057qib7 13901 5 had have VBD cord-005453-4057qib7 13901 6 no no DT cord-005453-4057qib7 13901 7 injections injection NNS cord-005453-4057qib7 13901 8 . . . cord-005453-4057qib7 13902 1 Overall overall JJ cord-005453-4057qib7 13902 2 attitude attitude NN cord-005453-4057qib7 13902 3 towards towards IN cord-005453-4057qib7 13902 4 toy toy NN cord-005453-4057qib7 13902 5 " " `` cord-005453-4057qib7 13902 6 patients patient NNS cord-005453-4057qib7 13902 7 " " '' cord-005453-4057qib7 13902 8 was be VBD cord-005453-4057qib7 13902 9 more more RBR cord-005453-4057qib7 13902 10 mild mild JJ cord-005453-4057qib7 13902 11 in in IN cord-005453-4057qib7 13902 12 the the DT cord-005453-4057qib7 13902 13 second second JJ cord-005453-4057qib7 13902 14 group group NN cord-005453-4057qib7 13902 15 . . . cord-005453-4057qib7 13903 1 Conclusions conclusion NNS cord-005453-4057qib7 13903 2 : : : cord-005453-4057qib7 13903 3 1 1 CD cord-005453-4057qib7 13903 4 . . . cord-005453-4057qib7 13904 1 During during IN cord-005453-4057qib7 13904 2 a a DT cord-005453-4057qib7 13904 3 play play NN cord-005453-4057qib7 13904 4 children child NNS cord-005453-4057qib7 13904 5 mostly mostly RB cord-005453-4057qib7 13904 6 use use VBP cord-005453-4057qib7 13904 7 the the DT cord-005453-4057qib7 13904 8 medical medical JJ cord-005453-4057qib7 13904 9 devices device NNS cord-005453-4057qib7 13904 10 which which WDT cord-005453-4057qib7 13904 11 cause cause VBP cord-005453-4057qib7 13904 12 them -PRON- PRP cord-005453-4057qib7 13904 13 most most JJS cord-005453-4057qib7 13904 14 discomfort discomfort NN cord-005453-4057qib7 13904 15 and/or and/or CC cord-005453-4057qib7 13904 16 pain pain NN cord-005453-4057qib7 13904 17 . . . cord-005453-4057qib7 13905 1 2 2 LS cord-005453-4057qib7 13905 2 . . . cord-005453-4057qib7 13906 1 Manipulating manipulate VBG cord-005453-4057qib7 13906 2 the the DT cord-005453-4057qib7 13906 3 items item NNS cord-005453-4057qib7 13906 4 children child NNS cord-005453-4057qib7 13906 5 illustrate illustrate VBP cord-005453-4057qib7 13906 6 their -PRON- PRP$ cord-005453-4057qib7 13906 7 own own JJ cord-005453-4057qib7 13906 8 impression impression NN cord-005453-4057qib7 13906 9 of of IN cord-005453-4057qib7 13906 10 medical medical JJ cord-005453-4057qib7 13906 11 procedures procedure NNS cord-005453-4057qib7 13906 12 , , , cord-005453-4057qib7 13906 13 which which WDT cord-005453-4057qib7 13906 14 are be VBP cord-005453-4057qib7 13906 15 most most RBS cord-005453-4057qib7 13906 16 unpleasant unpleasant JJ cord-005453-4057qib7 13906 17 . . . cord-005453-4057qib7 13907 1 3 3 LS cord-005453-4057qib7 13907 2 . . . cord-005453-4057qib7 13908 1 Children child NNS cord-005453-4057qib7 13908 2 may may MD cord-005453-4057qib7 13908 3 express express VB cord-005453-4057qib7 13908 4 their -PRON- PRP$ cord-005453-4057qib7 13908 5 negative negative JJ cord-005453-4057qib7 13908 6 emotions emotion NNS cord-005453-4057qib7 13908 7 directed direct VBN cord-005453-4057qib7 13908 8 towards towards IN cord-005453-4057qib7 13908 9 medical medical JJ cord-005453-4057qib7 13908 10 manipulations manipulation NNS cord-005453-4057qib7 13908 11 via via IN cord-005453-4057qib7 13908 12 their -PRON- PRP$ cord-005453-4057qib7 13908 13 play play NN cord-005453-4057qib7 13908 14 actions action NNS cord-005453-4057qib7 13908 15 , , , cord-005453-4057qib7 13908 16 these these DT cord-005453-4057qib7 13908 17 negative negative JJ cord-005453-4057qib7 13908 18 reactions reaction NNS cord-005453-4057qib7 13908 19 may may MD cord-005453-4057qib7 13908 20 be be VB cord-005453-4057qib7 13908 21 suppressed suppress VBN cord-005453-4057qib7 13908 22 in in IN cord-005453-4057qib7 13908 23 different different JJ cord-005453-4057qib7 13908 24 ways way NNS cord-005453-4057qib7 13908 25 by by IN cord-005453-4057qib7 13908 26 parents parent NNS cord-005453-4057qib7 13908 27 or or CC cord-005453-4057qib7 13908 28 medical medical JJ cord-005453-4057qib7 13908 29 staff staff NN cord-005453-4057qib7 13908 30 . . . cord-005453-4057qib7 13909 1 4 4 LS cord-005453-4057qib7 13909 2 . . . cord-005453-4057qib7 13910 1 The the DT cord-005453-4057qib7 13910 2 intensity intensity NN cord-005453-4057qib7 13910 3 of of IN cord-005453-4057qib7 13910 4 child child NN cord-005453-4057qib7 13910 5 's 's POS cord-005453-4057qib7 13910 6 own own JJ cord-005453-4057qib7 13910 7 traumatic traumatic JJ cord-005453-4057qib7 13910 8 experience experience NN cord-005453-4057qib7 13910 9 and and CC cord-005453-4057qib7 13910 10 an an DT cord-005453-4057qib7 13910 11 attitude attitude NN cord-005453-4057qib7 13910 12 of of IN cord-005453-4057qib7 13910 13 nearby nearby JJ cord-005453-4057qib7 13910 14 adults adult NNS cord-005453-4057qib7 13910 15 may may MD cord-005453-4057qib7 13910 16 influence influence VB cord-005453-4057qib7 13910 17 the the DT cord-005453-4057qib7 13910 18 child child NN cord-005453-4057qib7 13910 19 's 's POS cord-005453-4057qib7 13910 20 attitude attitude NN cord-005453-4057qib7 13910 21 towards towards IN cord-005453-4057qib7 13910 22 other other JJ cord-005453-4057qib7 13910 23 patients patient NNS cord-005453-4057qib7 13910 24 . . . cord-005453-4057qib7 13911 1 5 5 LS cord-005453-4057qib7 13911 2 . . . cord-005453-4057qib7 13912 1 The the DT cord-005453-4057qib7 13912 2 mother mother NN cord-005453-4057qib7 13912 3 's 's POS cord-005453-4057qib7 13912 4 wish wish NN cord-005453-4057qib7 13912 5 for for IN cord-005453-4057qib7 13912 6 a a DT cord-005453-4057qib7 13912 7 child child NN cord-005453-4057qib7 13912 8 to to TO cord-005453-4057qib7 13912 9 tolerate tolerate VB cord-005453-4057qib7 13912 10 all all DT cord-005453-4057qib7 13912 11 medical medical JJ cord-005453-4057qib7 13912 12 procedures procedure NNS cord-005453-4057qib7 13912 13 with with IN cord-005453-4057qib7 13912 14 ease ease NN cord-005453-4057qib7 13912 15 exceeds exceed VBZ cord-005453-4057qib7 13912 16 real real JJ cord-005453-4057qib7 13912 17 capabilities capability NNS cord-005453-4057qib7 13912 18 of of IN cord-005453-4057qib7 13912 19 a a DT cord-005453-4057qib7 13912 20 small small JJ cord-005453-4057qib7 13912 21 child child NN cord-005453-4057qib7 13912 22 . . . cord-005453-4057qib7 13913 1 Disclosure disclosure NN cord-005453-4057qib7 13913 2 : : : cord-005453-4057qib7 13913 3 Nothing nothing NN cord-005453-4057qib7 13913 4 to to TO cord-005453-4057qib7 13913 5 declare declare VB cord-005453-4057qib7 13913 6 . . . cord-005453-4057qib7 13914 1 Allogeneic allogeneic IN cord-005453-4057qib7 13914 2 stem stem VBP cord-005453-4057qib7 13914 3 cell cell NN cord-005453-4057qib7 13914 4 transplantation transplantation NN cord-005453-4057qib7 13914 5 in in IN cord-005453-4057qib7 13914 6 patients patient NNS cord-005453-4057qib7 13914 7 with with IN cord-005453-4057qib7 13914 8 mucopolysaccharidosis mucopolysaccharidosis NN cord-005453-4057qib7 13914 9 type type NN cord-005453-4057qib7 13914 10 IIIA IIIA NNP cord-005453-4057qib7 13914 11 ( ( -LRB- cord-005453-4057qib7 13914 12 Sanfilippo Sanfilippo NNP cord-005453-4057qib7 13914 13 ) ) -RRB- cord-005453-4057qib7 13915 1 : : : cord-005453-4057qib7 13915 2 A a DT cord-005453-4057qib7 13915 3 case case NN cord-005453-4057qib7 13916 1 series series NNP cord-005453-4057qib7 13916 2 Methods Methods NNPS cord-005453-4057qib7 13917 1 : : : cord-005453-4057qib7 13917 2 Allogeneic Allogeneic NNP cord-005453-4057qib7 13917 3 SCT SCT NNP cord-005453-4057qib7 13917 4 was be VBD cord-005453-4057qib7 13917 5 performed perform VBN cord-005453-4057qib7 13917 6 at at IN cord-005453-4057qib7 13917 7 the the DT cord-005453-4057qib7 13917 8 ages age NNS cord-005453-4057qib7 13917 9 of of IN cord-005453-4057qib7 13917 10 2 2 CD cord-005453-4057qib7 13917 11 , , , cord-005453-4057qib7 13917 12 5 5 CD cord-005453-4057qib7 13917 13 and and CC cord-005453-4057qib7 13917 14 4 4 CD cord-005453-4057qib7 13917 15 years year NNS cord-005453-4057qib7 13917 16 , , , cord-005453-4057qib7 13917 17 respectively respectively RB cord-005453-4057qib7 13917 18 . . . cord-005453-4057qib7 13918 1 All all DT cord-005453-4057qib7 13918 2 three three CD cord-005453-4057qib7 13918 3 patients patient NNS cord-005453-4057qib7 13918 4 received receive VBD cord-005453-4057qib7 13918 5 intrathecal intrathecal JJ cord-005453-4057qib7 13918 6 enzyme enzyme NN cord-005453-4057qib7 13918 7 replacement replacement NN cord-005453-4057qib7 13918 8 therapy therapy NN cord-005453-4057qib7 13918 9 within within IN cord-005453-4057qib7 13918 10 a a DT cord-005453-4057qib7 13918 11 clinical clinical JJ cord-005453-4057qib7 13918 12 trial trial NN cord-005453-4057qib7 13918 13 setting set VBG cord-005453-4057qib7 13918 14 prior prior RB cord-005453-4057qib7 13918 15 to to IN cord-005453-4057qib7 13918 16 HSCT HSCT NNP cord-005453-4057qib7 13918 17 . . . cord-005453-4057qib7 13919 1 The the DT cord-005453-4057qib7 13919 2 conditioning conditioning NN cord-005453-4057qib7 13919 3 regimen regimen NN cord-005453-4057qib7 13919 4 consisted consist VBD cord-005453-4057qib7 13919 5 of of IN cord-005453-4057qib7 13919 6 treosulfan treosulfan NNP cord-005453-4057qib7 13919 7 , , , cord-005453-4057qib7 13919 8 fludarabine fludarabine NN cord-005453-4057qib7 13919 9 , , , cord-005453-4057qib7 13919 10 thiotepa thiotepa JJ cord-005453-4057qib7 13919 11 and and CC cord-005453-4057qib7 13919 12 thymoglobuline thymoglobuline NNP cord-005453-4057qib7 13919 13 . . . cord-005453-4057qib7 13920 1 GvHD gvhd NN cord-005453-4057qib7 13920 2 - - HYPH cord-005453-4057qib7 13920 3 prophylaxis prophylaxis NN cord-005453-4057qib7 13920 4 was be VBD cord-005453-4057qib7 13920 5 carried carry VBN cord-005453-4057qib7 13920 6 out out RP cord-005453-4057qib7 13920 7 with with IN cord-005453-4057qib7 13920 8 CSA CSA NNP cord-005453-4057qib7 13920 9 and and CC cord-005453-4057qib7 13920 10 MTX MTX NNP cord-005453-4057qib7 13920 11 in in IN cord-005453-4057qib7 13920 12 two two CD cord-005453-4057qib7 13920 13 patients patient NNS cord-005453-4057qib7 13920 14 and and CC cord-005453-4057qib7 13920 15 CSA CSA NNP cord-005453-4057qib7 13920 16 and and CC cord-005453-4057qib7 13920 17 MMF MMF NNP cord-005453-4057qib7 13920 18 in in IN cord-005453-4057qib7 13920 19 one one CD cord-005453-4057qib7 13920 20 patient patient NN cord-005453-4057qib7 13920 21 . . . cord-005453-4057qib7 13921 1 Stem stem JJ cord-005453-4057qib7 13921 2 cell cell NN cord-005453-4057qib7 13921 3 source source NN cord-005453-4057qib7 13921 4 was be VBD cord-005453-4057qib7 13921 5 bone bone NN cord-005453-4057qib7 13921 6 marrow marrow NN cord-005453-4057qib7 13921 7 in in IN cord-005453-4057qib7 13921 8 two two CD cord-005453-4057qib7 13921 9 patients patient NNS cord-005453-4057qib7 13921 10 and and CC cord-005453-4057qib7 13921 11 peripheral peripheral JJ cord-005453-4057qib7 13921 12 blood blood NN cord-005453-4057qib7 13921 13 stem stem NN cord-005453-4057qib7 13921 14 cells cell NNS cord-005453-4057qib7 13921 15 in in IN cord-005453-4057qib7 13921 16 one one CD cord-005453-4057qib7 13921 17 patient patient NN cord-005453-4057qib7 13921 18 . . . cord-005453-4057qib7 13922 1 Results result NNS cord-005453-4057qib7 13922 2 : : : cord-005453-4057qib7 13923 1 The the DT cord-005453-4057qib7 13923 2 conditioning conditioning NN cord-005453-4057qib7 13923 3 regimen regimen NN cord-005453-4057qib7 13923 4 was be VBD cord-005453-4057qib7 13923 5 well well RB cord-005453-4057qib7 13923 6 tolerated tolerate VBN cord-005453-4057qib7 13923 7 and and CC cord-005453-4057qib7 13923 8 all all DT cord-005453-4057qib7 13923 9 three three CD cord-005453-4057qib7 13923 10 patients patient NNS cord-005453-4057qib7 13923 11 successfully successfully RB cord-005453-4057qib7 13923 12 engrafted engraft VBD cord-005453-4057qib7 13923 13 . . . cord-005453-4057qib7 13924 1 Two two CD cord-005453-4057qib7 13924 2 of of IN cord-005453-4057qib7 13924 3 three three CD cord-005453-4057qib7 13924 4 patients patient NNS cord-005453-4057qib7 13924 5 had have VBD cord-005453-4057qib7 13924 6 an an DT cord-005453-4057qib7 13924 7 uncomplicated uncomplicated JJ cord-005453-4057qib7 13924 8 course course NN cord-005453-4057qib7 13924 9 without without IN cord-005453-4057qib7 13924 10 occurrence occurrence NN cord-005453-4057qib7 13924 11 of of IN cord-005453-4057qib7 13924 12 acute acute JJ cord-005453-4057qib7 13924 13 or or CC cord-005453-4057qib7 13924 14 chronic chronic JJ cord-005453-4057qib7 13924 15 graft graft NN cord-005453-4057qib7 13924 16 - - HYPH cord-005453-4057qib7 13924 17 versus versus IN cord-005453-4057qib7 13924 18 - - HYPH cord-005453-4057qib7 13924 19 host host NN cord-005453-4057qib7 13924 20 - - HYPH cord-005453-4057qib7 13924 21 disease disease NN cord-005453-4057qib7 13924 22 ( ( -LRB- cord-005453-4057qib7 13924 23 GVHD GVHD NNP cord-005453-4057qib7 13924 24 ) ) -RRB- cord-005453-4057qib7 13924 25 . . . cord-005453-4057qib7 13925 1 At at IN cord-005453-4057qib7 13925 2 last last JJ cord-005453-4057qib7 13925 3 follow follow NN cord-005453-4057qib7 13925 4 - - HYPH cord-005453-4057qib7 13925 5 up up NN cord-005453-4057qib7 13925 6 12 12 CD cord-005453-4057qib7 13925 7 and and CC cord-005453-4057qib7 13925 8 15 15 CD cord-005453-4057qib7 13925 9 months month NNS cord-005453-4057qib7 13925 10 after after IN cord-005453-4057qib7 13925 11 HSCT HSCT NNP cord-005453-4057qib7 13925 12 , , , cord-005453-4057qib7 13925 13 both both DT cord-005453-4057qib7 13925 14 patients patient NNS cord-005453-4057qib7 13925 15 are be VBP cord-005453-4057qib7 13925 16 in in IN cord-005453-4057qib7 13925 17 good good JJ cord-005453-4057qib7 13925 18 condition condition NN cord-005453-4057qib7 13925 19 and and CC cord-005453-4057qib7 13925 20 show show VB cord-005453-4057qib7 13925 21 constant constant JJ cord-005453-4057qib7 13925 22 progress progress NN cord-005453-4057qib7 13925 23 of of IN cord-005453-4057qib7 13925 24 psychomotor psychomotor NN cord-005453-4057qib7 13925 25 development development NN cord-005453-4057qib7 13925 26 . . . cord-005453-4057qib7 13926 1 The the DT cord-005453-4057qib7 13926 2 third third JJ cord-005453-4057qib7 13926 3 patient patient NN cord-005453-4057qib7 13926 4 experienced experience VBD cord-005453-4057qib7 13926 5 severe severe JJ cord-005453-4057qib7 13926 6 steroid steroid NN cord-005453-4057qib7 13926 7 refractory refractory JJ cord-005453-4057qib7 13926 8 acute acute JJ cord-005453-4057qib7 13926 9 GVHD GVHD NNP cord-005453-4057qib7 13926 10 of of IN cord-005453-4057qib7 13926 11 intestines intestine NNS cord-005453-4057qib7 13926 12 ( ( -LRB- cord-005453-4057qib7 13926 13 stage stage NN cord-005453-4057qib7 13926 14 4 4 CD cord-005453-4057qib7 13926 15 ) ) -RRB- cord-005453-4057qib7 13926 16 and and CC cord-005453-4057qib7 13926 17 skin skin NN cord-005453-4057qib7 13926 18 ( ( -LRB- cord-005453-4057qib7 13926 19 stage stage NN cord-005453-4057qib7 13926 20 3 3 CD cord-005453-4057qib7 13926 21 ) ) -RRB- cord-005453-4057qib7 13926 22 , , , cord-005453-4057qib7 13926 23 which which WDT cord-005453-4057qib7 13926 24 resolved resolve VBD cord-005453-4057qib7 13926 25 under under IN cord-005453-4057qib7 13926 26 intensive intensive JJ cord-005453-4057qib7 13926 27 immunosuppression immunosuppression NN cord-005453-4057qib7 13926 28 with with IN cord-005453-4057qib7 13926 29 cyclosporine cyclosporine NN cord-005453-4057qib7 13926 30 , , , cord-005453-4057qib7 13926 31 mycophenolate mycophenolate JJ cord-005453-4057qib7 13926 32 and and CC cord-005453-4057qib7 13926 33 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 13926 34 . . . cord-005453-4057qib7 13927 1 Around around IN cord-005453-4057qib7 13927 2 day day NN cord-005453-4057qib7 13927 3 110 110 CD cord-005453-4057qib7 13927 4 after after IN cord-005453-4057qib7 13927 5 HSCT HSCT NNP cord-005453-4057qib7 13927 6 , , , cord-005453-4057qib7 13927 7 this this DT cord-005453-4057qib7 13927 8 patient patient NN cord-005453-4057qib7 13927 9 showed show VBD cord-005453-4057qib7 13927 10 clinical clinical JJ cord-005453-4057qib7 13927 11 and and CC cord-005453-4057qib7 13927 12 biochemical biochemical JJ cord-005453-4057qib7 13927 13 signs sign NNS cord-005453-4057qib7 13927 14 of of IN cord-005453-4057qib7 13927 15 transplant transplant NN cord-005453-4057qib7 13927 16 - - HYPH cord-005453-4057qib7 13927 17 associated associate VBN cord-005453-4057qib7 13927 18 microangiopathy microangiopathy NN cord-005453-4057qib7 13927 19 ( ( -LRB- cord-005453-4057qib7 13927 20 TMA TMA NNP cord-005453-4057qib7 13927 21 ) ) -RRB- cord-005453-4057qib7 13927 22 with with IN cord-005453-4057qib7 13927 23 cerebral cerebral JJ cord-005453-4057qib7 13927 24 seizures seizure NNS cord-005453-4057qib7 13927 25 and and CC cord-005453-4057qib7 13927 26 acute acute JJ cord-005453-4057qib7 13927 27 renal renal JJ cord-005453-4057qib7 13927 28 failure failure NN cord-005453-4057qib7 13927 29 . . . cord-005453-4057qib7 13928 1 The the DT cord-005453-4057qib7 13928 2 cerebral cerebral JJ cord-005453-4057qib7 13928 3 MRI MRI NNP cord-005453-4057qib7 13928 4 showed show VBD cord-005453-4057qib7 13928 5 progressive progressive JJ cord-005453-4057qib7 13928 6 cerebral cerebral JJ cord-005453-4057qib7 13928 7 atrophy atrophy NN cord-005453-4057qib7 13928 8 and and CC cord-005453-4057qib7 13928 9 leukoencephalopathy leukoencephalopathy NNP cord-005453-4057qib7 13928 10 , , , cord-005453-4057qib7 13928 11 also also RB cord-005453-4057qib7 13928 12 consistent consistent JJ cord-005453-4057qib7 13928 13 with with IN cord-005453-4057qib7 13928 14 a a DT cord-005453-4057qib7 13928 15 progress progress NN cord-005453-4057qib7 13928 16 of of IN cord-005453-4057qib7 13928 17 the the DT cord-005453-4057qib7 13928 18 MPS MPS NNP cord-005453-4057qib7 13928 19 IIIa iiia NN cord-005453-4057qib7 13928 20 . . . cord-005453-4057qib7 13929 1 At at IN cord-005453-4057qib7 13929 2 last last JJ cord-005453-4057qib7 13929 3 follow follow NN cord-005453-4057qib7 13929 4 - - HYPH cord-005453-4057qib7 13929 5 up up NN cord-005453-4057qib7 13929 6 15 15 CD cord-005453-4057qib7 13929 7 months month NNS cord-005453-4057qib7 13929 8 after after IN cord-005453-4057qib7 13929 9 HSCT HSCT NNP cord-005453-4057qib7 13929 10 , , , cord-005453-4057qib7 13929 11 this this DT cord-005453-4057qib7 13929 12 patient patient NN cord-005453-4057qib7 13929 13 had have VBD cord-005453-4057qib7 13929 14 recovered recover VBN cord-005453-4057qib7 13929 15 from from IN cord-005453-4057qib7 13929 16 TMA TMA NNP cord-005453-4057qib7 13929 17 and and CC cord-005453-4057qib7 13929 18 was be VBD cord-005453-4057qib7 13929 19 in in IN cord-005453-4057qib7 13929 20 a a DT cord-005453-4057qib7 13929 21 stable stable JJ cord-005453-4057qib7 13929 22 clinical clinical JJ cord-005453-4057qib7 13929 23 condition condition NN cord-005453-4057qib7 13929 24 . . . cord-005453-4057qib7 13930 1 Conclusions conclusion NNS cord-005453-4057qib7 13930 2 : : : cord-005453-4057qib7 13931 1 In in IN cord-005453-4057qib7 13931 2 consideration consideration NN cord-005453-4057qib7 13931 3 of of IN cord-005453-4057qib7 13931 4 the the DT cord-005453-4057qib7 13931 5 small small JJ cord-005453-4057qib7 13931 6 case case NN cord-005453-4057qib7 13931 7 number number NN cord-005453-4057qib7 13931 8 and and CC cord-005453-4057qib7 13931 9 the the DT cord-005453-4057qib7 13931 10 short short JJ cord-005453-4057qib7 13931 11 follow follow NN cord-005453-4057qib7 13931 12 - - HYPH cord-005453-4057qib7 13931 13 up up NN cord-005453-4057qib7 13931 14 period period NN cord-005453-4057qib7 13931 15 in in IN cord-005453-4057qib7 13931 16 our -PRON- PRP$ cord-005453-4057qib7 13931 17 cohort cohort NN cord-005453-4057qib7 13931 18 , , , cord-005453-4057qib7 13931 19 allogeneic allogeneic IN cord-005453-4057qib7 13931 20 HSCT HSCT NNP cord-005453-4057qib7 13931 21 might may MD cord-005453-4057qib7 13931 22 be be VB cord-005453-4057qib7 13931 23 considered consider VBN cord-005453-4057qib7 13931 24 as as IN cord-005453-4057qib7 13931 25 a a DT cord-005453-4057qib7 13931 26 salvage salvage NN cord-005453-4057qib7 13931 27 therapy therapy NN cord-005453-4057qib7 13931 28 for for IN cord-005453-4057qib7 13931 29 patients patient NNS cord-005453-4057qib7 13931 30 with with IN cord-005453-4057qib7 13931 31 MPS MPS NNP cord-005453-4057qib7 13931 32 IIIa iiia NN cord-005453-4057qib7 13931 33 if if IN cord-005453-4057qib7 13931 34 other other JJ cord-005453-4057qib7 13931 35 therapeutic therapeutic JJ cord-005453-4057qib7 13931 36 options option NNS cord-005453-4057qib7 13931 37 are be VBP cord-005453-4057qib7 13931 38 unavailable unavailable JJ cord-005453-4057qib7 13931 39 for for IN cord-005453-4057qib7 13931 40 children child NNS cord-005453-4057qib7 13931 41 with with IN cord-005453-4057qib7 13931 42 this this DT cord-005453-4057qib7 13931 43 otherwise otherwise RB cord-005453-4057qib7 13931 44 unfavourable unfavourable JJ cord-005453-4057qib7 13931 45 prognosis prognosis NN cord-005453-4057qib7 13931 46 . . . cord-005453-4057qib7 13932 1 However however RB cord-005453-4057qib7 13932 2 , , , cord-005453-4057qib7 13932 3 the the DT cord-005453-4057qib7 13932 4 early early JJ cord-005453-4057qib7 13932 5 psychoneurological psychoneurological JJ cord-005453-4057qib7 13932 6 course course NN cord-005453-4057qib7 13932 7 after after IN cord-005453-4057qib7 13932 8 transplant transplant NN cord-005453-4057qib7 13932 9 seems seem VBZ cord-005453-4057qib7 13932 10 promising promise VBG cord-005453-4057qib7 13932 11 compared compare VBN cord-005453-4057qib7 13932 12 to to IN cord-005453-4057qib7 13932 13 the the DT cord-005453-4057qib7 13932 14 literature literature NN cord-005453-4057qib7 13932 15 and and CC cord-005453-4057qib7 13932 16 HSCT HSCT NNP cord-005453-4057qib7 13932 17 could could MD cord-005453-4057qib7 13932 18 become become VB cord-005453-4057qib7 13932 19 a a DT cord-005453-4057qib7 13932 20 treatment treatment NN cord-005453-4057qib7 13932 21 option option NN cord-005453-4057qib7 13932 22 for for IN cord-005453-4057qib7 13932 23 this this DT cord-005453-4057qib7 13932 24 rare rare JJ cord-005453-4057qib7 13932 25 disease disease NN cord-005453-4057qib7 13932 26 . . . cord-005453-4057qib7 13933 1 Disclosure disclosure NN cord-005453-4057qib7 13933 2 : : : cord-005453-4057qib7 13933 3 Nothing nothing NN cord-005453-4057qib7 13933 4 to to TO cord-005453-4057qib7 13933 5 declare declare VB cord-005453-4057qib7 13933 6 Methods method NNS cord-005453-4057qib7 13933 7 : : : cord-005453-4057qib7 13933 8 For for IN cord-005453-4057qib7 13933 9 the the DT cord-005453-4057qib7 13933 10 identification identification NN cord-005453-4057qib7 13933 11 of of IN cord-005453-4057qib7 13933 12 underlying underlie VBG cord-005453-4057qib7 13933 13 molecular molecular JJ cord-005453-4057qib7 13933 14 mechanisms mechanism NNS cord-005453-4057qib7 13933 15 leading lead VBG cord-005453-4057qib7 13933 16 to to IN cord-005453-4057qib7 13933 17 the the DT cord-005453-4057qib7 13933 18 increased increase VBN cord-005453-4057qib7 13933 19 sensibility sensibility NN cord-005453-4057qib7 13933 20 of of IN cord-005453-4057qib7 13933 21 RMS RMS NNP cord-005453-4057qib7 13933 22 cells cell NNS cord-005453-4057qib7 13933 23 , , , cord-005453-4057qib7 13933 24 the the DT cord-005453-4057qib7 13933 25 activation activation NN cord-005453-4057qib7 13933 26 status status NN cord-005453-4057qib7 13933 27 of of IN cord-005453-4057qib7 13933 28 different different JJ cord-005453-4057qib7 13933 29 NF nf NN cord-005453-4057qib7 13933 30 - - HYPH cord-005453-4057qib7 13933 31 kB kB NNP cord-005453-4057qib7 13933 32 signaling signal VBG cord-005453-4057qib7 13933 33 pathways pathway NNS cord-005453-4057qib7 13933 34 were be VBD cord-005453-4057qib7 13933 35 analyzed analyze VBN cord-005453-4057qib7 13933 36 using use VBG cord-005453-4057qib7 13933 37 western western JJ cord-005453-4057qib7 13933 38 blot blot NN cord-005453-4057qib7 13933 39 analysis analysis NN cord-005453-4057qib7 13933 40 and and CC cord-005453-4057qib7 13933 41 quantitative quantitative JJ cord-005453-4057qib7 13933 42 real real JJ cord-005453-4057qib7 13933 43 time time NN cord-005453-4057qib7 13933 44 PCR PCR NNP cord-005453-4057qib7 13933 45 ( ( -LRB- cord-005453-4057qib7 13933 46 qPCR qPCR NNP cord-005453-4057qib7 13933 47 ) ) -RRB- cord-005453-4057qib7 13933 48 . . . cord-005453-4057qib7 13934 1 Further further RB cord-005453-4057qib7 13934 2 , , , cord-005453-4057qib7 13934 3 flow flow NN cord-005453-4057qib7 13934 4 cytometry cytometry NN cord-005453-4057qib7 13934 5 was be VBD cord-005453-4057qib7 13934 6 used use VBN cord-005453-4057qib7 13934 7 to to TO cord-005453-4057qib7 13934 8 analyze analyze VB cord-005453-4057qib7 13934 9 the the DT cord-005453-4057qib7 13934 10 surface surface NN cord-005453-4057qib7 13934 11 expression expression NN cord-005453-4057qib7 13934 12 of of IN cord-005453-4057qib7 13934 13 death death NN cord-005453-4057qib7 13934 14 receptors receptor NNS cord-005453-4057qib7 13934 15 on on IN cord-005453-4057qib7 13934 16 either either CC cord-005453-4057qib7 13934 17 SM SM NNP cord-005453-4057qib7 13934 18 treated treat VBN cord-005453-4057qib7 13934 19 or or CC cord-005453-4057qib7 13934 20 untreated untreated JJ cord-005453-4057qib7 13934 21 RMS RMS NNP cord-005453-4057qib7 13934 22 cells cell NNS cord-005453-4057qib7 13934 23 . . . cord-005453-4057qib7 13935 1 The the DT cord-005453-4057qib7 13935 2 overall overall JJ cord-005453-4057qib7 13935 3 effect effect NN cord-005453-4057qib7 13935 4 on on IN cord-005453-4057qib7 13935 5 cell cell NN cord-005453-4057qib7 13935 6 death death NN cord-005453-4057qib7 13935 7 induction induction NN cord-005453-4057qib7 13935 8 was be VBD cord-005453-4057qib7 13935 9 measured measure VBN cord-005453-4057qib7 13935 10 by by IN cord-005453-4057qib7 13935 11 PI PI NNP cord-005453-4057qib7 13935 12 / / SYM cord-005453-4057qib7 13935 13 Hoechst Hoechst NNP cord-005453-4057qib7 13935 14 staining stain VBG cord-005453-4057qib7 13935 15 using use VBG cord-005453-4057qib7 13935 16 a a DT cord-005453-4057qib7 13935 17 fluorescent fluorescent JJ cord-005453-4057qib7 13935 18 microscope microscope NN cord-005453-4057qib7 13935 19 . . . cord-005453-4057qib7 13936 1 Results result NNS cord-005453-4057qib7 13936 2 : : : cord-005453-4057qib7 13937 1 Treatment treatment NN cord-005453-4057qib7 13937 2 with with IN cord-005453-4057qib7 13937 3 SM SM NNP cord-005453-4057qib7 13937 4 led lead VBD cord-005453-4057qib7 13937 5 to to IN cord-005453-4057qib7 13937 6 the the DT cord-005453-4057qib7 13937 7 suspected suspect VBN cord-005453-4057qib7 13937 8 degradation degradation NN cord-005453-4057qib7 13937 9 of of IN cord-005453-4057qib7 13937 10 IAPs IAPs NNP cord-005453-4057qib7 13937 11 . . . cord-005453-4057qib7 13938 1 Followed follow VBN cord-005453-4057qib7 13938 2 by by IN cord-005453-4057qib7 13938 3 the the DT cord-005453-4057qib7 13938 4 activation activation NN cord-005453-4057qib7 13938 5 of of IN cord-005453-4057qib7 13938 6 both both CC cord-005453-4057qib7 13938 7 the the DT cord-005453-4057qib7 13938 8 canonical canonical JJ cord-005453-4057qib7 13938 9 NF nf NN cord-005453-4057qib7 13938 10 - - HYPH cord-005453-4057qib7 13938 11 κB κB NNP cord-005453-4057qib7 13938 12 signaling signal VBG cord-005453-4057qib7 13938 13 pathway pathway NN cord-005453-4057qib7 13938 14 , , , cord-005453-4057qib7 13938 15 indicated indicate VBN cord-005453-4057qib7 13938 16 by by IN cord-005453-4057qib7 13938 17 the the DT cord-005453-4057qib7 13938 18 phosphorylation phosphorylation NN cord-005453-4057qib7 13938 19 of of IN cord-005453-4057qib7 13938 20 IκBα IκBα NNP cord-005453-4057qib7 13938 21 and and CC cord-005453-4057qib7 13938 22 p65 p65 ADD cord-005453-4057qib7 13938 23 , , , cord-005453-4057qib7 13938 24 and and CC cord-005453-4057qib7 13938 25 the the DT cord-005453-4057qib7 13938 26 non non JJ cord-005453-4057qib7 13938 27 - - JJ cord-005453-4057qib7 13938 28 canonical canonical JJ cord-005453-4057qib7 13938 29 NF nf NN cord-005453-4057qib7 13938 30 - - HYPH cord-005453-4057qib7 13938 31 κB κB NNP cord-005453-4057qib7 13938 32 signaling signal VBG cord-005453-4057qib7 13938 33 pathway pathway NN cord-005453-4057qib7 13938 34 , , , cord-005453-4057qib7 13938 35 as as IN cord-005453-4057qib7 13938 36 indicated indicate VBN cord-005453-4057qib7 13938 37 by by IN cord-005453-4057qib7 13938 38 the the DT cord-005453-4057qib7 13938 39 accumulation accumulation NN cord-005453-4057qib7 13938 40 of of IN cord-005453-4057qib7 13938 41 NIK NIK NNP cord-005453-4057qib7 13938 42 and and CC cord-005453-4057qib7 13938 43 the the DT cord-005453-4057qib7 13938 44 degradation degradation NN cord-005453-4057qib7 13938 45 of of IN cord-005453-4057qib7 13938 46 p100 p100 NNP cord-005453-4057qib7 13938 47 to to IN cord-005453-4057qib7 13938 48 p52 p52 NNP cord-005453-4057qib7 13938 49 . . . cord-005453-4057qib7 13939 1 Determination determination NN cord-005453-4057qib7 13939 2 of of IN cord-005453-4057qib7 13939 3 selected select VBN cord-005453-4057qib7 13939 4 target target NN cord-005453-4057qib7 13939 5 gene gene NN cord-005453-4057qib7 13939 6 transcription transcription NN cord-005453-4057qib7 13939 7 revealed reveal VBD cord-005453-4057qib7 13939 8 an an DT cord-005453-4057qib7 13939 9 upregulation upregulation NN cord-005453-4057qib7 13939 10 of of IN cord-005453-4057qib7 13939 11 the the DT cord-005453-4057qib7 13939 12 inhibitor inhibitor NN cord-005453-4057qib7 13939 13 IκBα IκBα NNP cord-005453-4057qib7 13939 14 , , , cord-005453-4057qib7 13939 15 NIK NIK NNP cord-005453-4057qib7 13939 16 , , , cord-005453-4057qib7 13939 17 p100 p100 NNP cord-005453-4057qib7 13939 18 , , , cord-005453-4057qib7 13939 19 IL-8 IL-8 NNP cord-005453-4057qib7 13939 20 and and CC cord-005453-4057qib7 13939 21 at at IN cord-005453-4057qib7 13939 22 later later JJ cord-005453-4057qib7 13939 23 time time NN cord-005453-4057qib7 13939 24 points point VBZ cord-005453-4057qib7 13939 25 the the DT cord-005453-4057qib7 13939 26 death death NN cord-005453-4057qib7 13939 27 receptors receptor NNS cord-005453-4057qib7 13939 28 TRAIL TRAIL NNP cord-005453-4057qib7 13939 29 - - HYPH cord-005453-4057qib7 13939 30 R1 R1 NNP cord-005453-4057qib7 13939 31 and and CC cord-005453-4057qib7 13939 32 TRAIL TRAIL NNP cord-005453-4057qib7 13939 33 - - HYPH cord-005453-4057qib7 13939 34 R2 R2 NNP cord-005453-4057qib7 13939 35 . . . cord-005453-4057qib7 13940 1 Analysis analysis NN cord-005453-4057qib7 13940 2 of of IN cord-005453-4057qib7 13940 3 gene gene NN cord-005453-4057qib7 13940 4 transcription transcription NN cord-005453-4057qib7 13940 5 also also RB cord-005453-4057qib7 13940 6 led lead VBD cord-005453-4057qib7 13940 7 to to IN cord-005453-4057qib7 13940 8 the the DT cord-005453-4057qib7 13940 9 finding finding NN cord-005453-4057qib7 13940 10 of of IN cord-005453-4057qib7 13940 11 neither neither DT cord-005453-4057qib7 13940 12 up up RB cord-005453-4057qib7 13940 13 - - HYPH cord-005453-4057qib7 13940 14 nor nor CC cord-005453-4057qib7 13940 15 downregulation downregulation NN cord-005453-4057qib7 13940 16 of of IN cord-005453-4057qib7 13940 17 cIAP1 ciap1 NN cord-005453-4057qib7 13940 18 and and CC cord-005453-4057qib7 13940 19 p65 p65 ADD cord-005453-4057qib7 13940 20 . . . cord-005453-4057qib7 13941 1 To to TO cord-005453-4057qib7 13941 2 evaluate evaluate VB cord-005453-4057qib7 13941 3 the the DT cord-005453-4057qib7 13941 4 involvement involvement NN cord-005453-4057qib7 13941 5 of of IN cord-005453-4057qib7 13941 6 TRAIL TRAIL NNP cord-005453-4057qib7 13941 7 - - HYPH cord-005453-4057qib7 13941 8 R1 R1 NNP cord-005453-4057qib7 13941 9 and and CC cord-005453-4057qib7 13941 10 TRAIL TRAIL NNP cord-005453-4057qib7 13941 11 - - HYPH cord-005453-4057qib7 13941 12 R2 R2 NNP cord-005453-4057qib7 13941 13 in in IN cord-005453-4057qib7 13941 14 the the DT cord-005453-4057qib7 13941 15 SM sm NN cord-005453-4057qib7 13941 16 induced induce VBN cord-005453-4057qib7 13941 17 sensitization sensitization NN cord-005453-4057qib7 13941 18 towards towards IN cord-005453-4057qib7 13941 19 NK NK NNP cord-005453-4057qib7 13941 20 cell cell NN cord-005453-4057qib7 13941 21 - - HYPH cord-005453-4057qib7 13941 22 mediated mediate VBN cord-005453-4057qib7 13941 23 killing killing NN cord-005453-4057qib7 13941 24 , , , cord-005453-4057qib7 13941 25 surface surface NN cord-005453-4057qib7 13941 26 expression expression NN cord-005453-4057qib7 13941 27 of of IN cord-005453-4057qib7 13941 28 both both DT cord-005453-4057qib7 13941 29 death death NN cord-005453-4057qib7 13941 30 receptors receptor NNS cord-005453-4057qib7 13941 31 was be VBD cord-005453-4057qib7 13941 32 analyzed analyze VBN cord-005453-4057qib7 13941 33 . . . cord-005453-4057qib7 13942 1 Treatment treatment NN cord-005453-4057qib7 13942 2 with with IN cord-005453-4057qib7 13942 3 SM sm NN cord-005453-4057qib7 13942 4 led lead VBD cord-005453-4057qib7 13942 5 not not RB cord-005453-4057qib7 13942 6 only only RB cord-005453-4057qib7 13942 7 to to IN cord-005453-4057qib7 13942 8 an an DT cord-005453-4057qib7 13942 9 induced induce VBN cord-005453-4057qib7 13942 10 transcription transcription NN cord-005453-4057qib7 13942 11 of of IN cord-005453-4057qib7 13942 12 TRAIL TRAIL NNP cord-005453-4057qib7 13942 13 - - HYPH cord-005453-4057qib7 13942 14 R1 R1 NNP cord-005453-4057qib7 13942 15 and and CC cord-005453-4057qib7 13942 16 TRAIL TRAIL NNP cord-005453-4057qib7 13942 17 - - HYPH cord-005453-4057qib7 13942 18 R2 R2 NNP cord-005453-4057qib7 13942 19 , , , cord-005453-4057qib7 13942 20 but but CC cord-005453-4057qib7 13942 21 also also RB cord-005453-4057qib7 13942 22 to to IN cord-005453-4057qib7 13942 23 an an DT cord-005453-4057qib7 13942 24 increased increase VBN cord-005453-4057qib7 13942 25 surface surface NN cord-005453-4057qib7 13942 26 presentation presentation NN cord-005453-4057qib7 13942 27 of of IN cord-005453-4057qib7 13942 28 TRAIL TRAIL NNP cord-005453-4057qib7 13942 29 - - HYPH cord-005453-4057qib7 13942 30 R2 R2 NNP cord-005453-4057qib7 13942 31 . . . cord-005453-4057qib7 13943 1 Subsequent subsequent JJ cord-005453-4057qib7 13943 2 ligation ligation NN cord-005453-4057qib7 13943 3 of of IN cord-005453-4057qib7 13943 4 TRAIL TRAIL NNP cord-005453-4057qib7 13943 5 - - HYPH cord-005453-4057qib7 13943 6 R2 R2 NNP cord-005453-4057qib7 13943 7 by by IN cord-005453-4057qib7 13943 8 either either CC cord-005453-4057qib7 13943 9 wt wt NN cord-005453-4057qib7 13943 10 - - HYPH cord-005453-4057qib7 13943 11 TRAIL TRAIL NNP cord-005453-4057qib7 13943 12 or or CC cord-005453-4057qib7 13943 13 a a DT cord-005453-4057qib7 13943 14 specific specific JJ cord-005453-4057qib7 13943 15 agonistic agonistic JJ cord-005453-4057qib7 13943 16 antibody antibody NN cord-005453-4057qib7 13943 17 ( ( -LRB- cord-005453-4057qib7 13943 18 ETR-2 ETR-2 NNP cord-005453-4057qib7 13943 19 ) ) -RRB- cord-005453-4057qib7 13943 20 resulted result VBD cord-005453-4057qib7 13943 21 in in IN cord-005453-4057qib7 13943 22 a a DT cord-005453-4057qib7 13943 23 significant significant JJ cord-005453-4057qib7 13943 24 increase increase NN cord-005453-4057qib7 13943 25 in in IN cord-005453-4057qib7 13943 26 cell cell NN cord-005453-4057qib7 13943 27 death death NN cord-005453-4057qib7 13943 28 induction induction NN cord-005453-4057qib7 13943 29 . . . cord-005453-4057qib7 13944 1 The the DT cord-005453-4057qib7 13944 2 aforementioned aforementioned JJ cord-005453-4057qib7 13944 3 analysis analysis NN cord-005453-4057qib7 13944 4 of of IN cord-005453-4057qib7 13944 5 gene gene NN cord-005453-4057qib7 13944 6 transcription transcription NN cord-005453-4057qib7 13944 7 hints hint NNS cord-005453-4057qib7 13944 8 towards towards IN cord-005453-4057qib7 13944 9 a a DT cord-005453-4057qib7 13944 10 bimodal bimodal JJ cord-005453-4057qib7 13944 11 feedback feedback NN cord-005453-4057qib7 13944 12 mechanism mechanism NN cord-005453-4057qib7 13944 13 regulating regulate VBG cord-005453-4057qib7 13944 14 both both DT cord-005453-4057qib7 13944 15 , , , cord-005453-4057qib7 13944 16 the the DT cord-005453-4057qib7 13944 17 canonical canonical JJ cord-005453-4057qib7 13944 18 and and CC cord-005453-4057qib7 13944 19 non non JJ cord-005453-4057qib7 13944 20 - - JJ cord-005453-4057qib7 13944 21 canonical canonical JJ cord-005453-4057qib7 13944 22 NF nf NN cord-005453-4057qib7 13944 23 - - HYPH cord-005453-4057qib7 13944 24 κB κB NNP cord-005453-4057qib7 13944 25 signaling signal VBG cord-005453-4057qib7 13944 26 pathway pathway NN cord-005453-4057qib7 13944 27 . . . cord-005453-4057qib7 13945 1 On on IN cord-005453-4057qib7 13945 2 the the DT cord-005453-4057qib7 13945 3 one one CD cord-005453-4057qib7 13945 4 side side NN cord-005453-4057qib7 13945 5 , , , cord-005453-4057qib7 13945 6 the the DT cord-005453-4057qib7 13945 7 canonical canonical JJ cord-005453-4057qib7 13945 8 pathway pathway NN cord-005453-4057qib7 13945 9 is be VBZ cord-005453-4057qib7 13945 10 negatively negatively RB cord-005453-4057qib7 13945 11 regulated regulate VBN cord-005453-4057qib7 13945 12 by by IN cord-005453-4057qib7 13945 13 the the DT cord-005453-4057qib7 13945 14 induced induce VBN cord-005453-4057qib7 13945 15 transcription transcription NN cord-005453-4057qib7 13945 16 of of IN cord-005453-4057qib7 13945 17 the the DT cord-005453-4057qib7 13945 18 inhibitor inhibitor NN cord-005453-4057qib7 13945 19 IκBα IκBα NNP cord-005453-4057qib7 13945 20 . . . cord-005453-4057qib7 13946 1 On on IN cord-005453-4057qib7 13946 2 the the DT cord-005453-4057qib7 13946 3 other other JJ cord-005453-4057qib7 13946 4 side side NN cord-005453-4057qib7 13946 5 , , , cord-005453-4057qib7 13946 6 the the DT cord-005453-4057qib7 13946 7 induced induce VBN cord-005453-4057qib7 13946 8 transcription transcription NN cord-005453-4057qib7 13946 9 of of IN cord-005453-4057qib7 13946 10 NIK NIK NNP cord-005453-4057qib7 13946 11 , , , cord-005453-4057qib7 13946 12 p100 p100 NNP cord-005453-4057qib7 13946 13 and and CC cord-005453-4057qib7 13946 14 RelB RelB NNP cord-005453-4057qib7 13946 15 points point NNS cord-005453-4057qib7 13946 16 towards towards IN cord-005453-4057qib7 13946 17 a a DT cord-005453-4057qib7 13946 18 positive positive JJ cord-005453-4057qib7 13946 19 feedback feedback NN cord-005453-4057qib7 13946 20 loop loop NN cord-005453-4057qib7 13946 21 of of IN cord-005453-4057qib7 13946 22 the the DT cord-005453-4057qib7 13946 23 non non JJ cord-005453-4057qib7 13946 24 - - JJ cord-005453-4057qib7 13946 25 canonical canonical JJ cord-005453-4057qib7 13946 26 pathway pathway NN cord-005453-4057qib7 13946 27 . . . cord-005453-4057qib7 13947 1 One one CD cord-005453-4057qib7 13947 2 mechanism mechanism NN cord-005453-4057qib7 13947 3 of of IN cord-005453-4057qib7 13947 4 the the DT cord-005453-4057qib7 13947 5 increased increase VBN cord-005453-4057qib7 13947 6 RMS rms NN cord-005453-4057qib7 13947 7 cell cell NN cord-005453-4057qib7 13947 8 sensitivity sensitivity NN cord-005453-4057qib7 13947 9 might may MD cord-005453-4057qib7 13947 10 be be VB cord-005453-4057qib7 13947 11 the the DT cord-005453-4057qib7 13947 12 induced induce VBN cord-005453-4057qib7 13947 13 transcription transcription NN cord-005453-4057qib7 13947 14 and and CC cord-005453-4057qib7 13947 15 surface surface NN cord-005453-4057qib7 13947 16 presentation presentation NN cord-005453-4057qib7 13947 17 of of IN cord-005453-4057qib7 13947 18 the the DT cord-005453-4057qib7 13947 19 death death NN cord-005453-4057qib7 13947 20 receptor receptor NN cord-005453-4057qib7 13947 21 TRAIL TRAIL NNP cord-005453-4057qib7 13947 22 - - HYPH cord-005453-4057qib7 13947 23 R2 R2 NNP cord-005453-4057qib7 13947 24 . . . cord-005453-4057qib7 13948 1 The the DT cord-005453-4057qib7 13948 2 involvement involvement NN cord-005453-4057qib7 13948 3 of of IN cord-005453-4057qib7 13948 4 TRAIL TRAIL NNP cord-005453-4057qib7 13948 5 receptors receptor NNS cord-005453-4057qib7 13948 6 is be VBZ cord-005453-4057qib7 13948 7 further further RB cord-005453-4057qib7 13948 8 validated validate VBN cord-005453-4057qib7 13948 9 by by IN cord-005453-4057qib7 13948 10 the the DT cord-005453-4057qib7 13948 11 cytotoxicity cytotoxicity NN cord-005453-4057qib7 13948 12 data datum NNS cord-005453-4057qib7 13948 13 , , , cord-005453-4057qib7 13948 14 illustrating illustrate VBG cord-005453-4057qib7 13948 15 a a DT cord-005453-4057qib7 13948 16 SM sm NN cord-005453-4057qib7 13948 17 mediated mediate VBN cord-005453-4057qib7 13948 18 sensitization sensitization NN cord-005453-4057qib7 13948 19 towards towards IN cord-005453-4057qib7 13948 20 a a DT cord-005453-4057qib7 13948 21 TRAIL trail NN cord-005453-4057qib7 13948 22 induced induce VBN cord-005453-4057qib7 13948 23 cell cell NN cord-005453-4057qib7 13948 24 death death NN cord-005453-4057qib7 13948 25 induction induction NN cord-005453-4057qib7 13948 26 . . . cord-005453-4057qib7 13949 1 This this DT cord-005453-4057qib7 13949 2 mode mode NN cord-005453-4057qib7 13949 3 of of IN cord-005453-4057qib7 13949 4 cell cell NN cord-005453-4057qib7 13949 5 death death NN cord-005453-4057qib7 13949 6 fits fit VBZ cord-005453-4057qib7 13949 7 to to IN cord-005453-4057qib7 13949 8 the the DT cord-005453-4057qib7 13949 9 previous previous JJ cord-005453-4057qib7 13949 10 research research NN cord-005453-4057qib7 13949 11 , , , cord-005453-4057qib7 13949 12 were be VBD cord-005453-4057qib7 13950 1 TRAIL TRAIL NNP cord-005453-4057qib7 13950 2 transcription transcription NN cord-005453-4057qib7 13950 3 could could MD cord-005453-4057qib7 13950 4 be be VB cord-005453-4057qib7 13950 5 induced induce VBN cord-005453-4057qib7 13950 6 in in IN cord-005453-4057qib7 13950 7 NK NK NNP cord-005453-4057qib7 13950 8 cells cell NNS cord-005453-4057qib7 13950 9 by by IN cord-005453-4057qib7 13950 10 SM sm NN cord-005453-4057qib7 13950 11 treatment treatment NN cord-005453-4057qib7 13950 12 . . . cord-005453-4057qib7 13951 1 The the DT cord-005453-4057qib7 13951 2 graphical graphical JJ cord-005453-4057qib7 13951 3 abstract abstract NN cord-005453-4057qib7 13951 4 shows show VBZ cord-005453-4057qib7 13951 5 the the DT cord-005453-4057qib7 13951 6 transcriptional transcriptional JJ cord-005453-4057qib7 13951 7 upregulation upregulation NN cord-005453-4057qib7 13951 8 of of IN cord-005453-4057qib7 13951 9 target target NN cord-005453-4057qib7 13951 10 genes gene NNS cord-005453-4057qib7 13951 11 leading lead VBG cord-005453-4057qib7 13951 12 to to IN cord-005453-4057qib7 13951 13 a a DT cord-005453-4057qib7 13951 14 putative putative JJ cord-005453-4057qib7 13951 15 bimodal bimodal JJ cord-005453-4057qib7 13951 16 NF nf NN cord-005453-4057qib7 13951 17 - - HYPH cord-005453-4057qib7 13951 18 kB kb CD cord-005453-4057qib7 13951 19 regulation regulation NN cord-005453-4057qib7 13951 20 and and CC cord-005453-4057qib7 13951 21 increased increase VBN cord-005453-4057qib7 13951 22 surface surface NN cord-005453-4057qib7 13951 23 presentation presentation NN cord-005453-4057qib7 13951 24 of of IN cord-005453-4057qib7 13951 25 TRAIL TRAIL NNP cord-005453-4057qib7 13951 26 - - HYPH cord-005453-4057qib7 13951 27 R2 R2 NNP cord-005453-4057qib7 13951 28 by by IN cord-005453-4057qib7 13951 29 treatment treatment NN cord-005453-4057qib7 13951 30 with with IN cord-005453-4057qib7 13951 31 Smac Smac NNP cord-005453-4057qib7 13951 32 mimetics mimetic NNS cord-005453-4057qib7 13951 33 . . . cord-005453-4057qib7 13952 1 Aim aim VB cord-005453-4057qib7 13952 2 : : : cord-005453-4057qib7 13952 3 To to TO cord-005453-4057qib7 13952 4 investigate investigate VB cord-005453-4057qib7 13952 5 the the DT cord-005453-4057qib7 13952 6 outcome outcome NN cord-005453-4057qib7 13952 7 of of IN cord-005453-4057qib7 13952 8 UCB UCB NNP cord-005453-4057qib7 13952 9 transplantation transplantation NN cord-005453-4057qib7 13952 10 in in IN cord-005453-4057qib7 13952 11 pediatric pediatric JJ cord-005453-4057qib7 13952 12 patients patient NNS cord-005453-4057qib7 13952 13 with with IN cord-005453-4057qib7 13952 14 malignant malignant JJ cord-005453-4057qib7 13952 15 and and CC cord-005453-4057qib7 13952 16 non non JJ cord-005453-4057qib7 13952 17 malignant malignant JJ cord-005453-4057qib7 13952 18 diseases disease NNS cord-005453-4057qib7 13952 19 Methods method NNS cord-005453-4057qib7 13952 20 : : : cord-005453-4057qib7 13952 21 Data datum NNS cord-005453-4057qib7 13952 22 from from IN cord-005453-4057qib7 13952 23 30 30 CD cord-005453-4057qib7 13952 24 patients patient NNS cord-005453-4057qib7 13952 25 underwent undergo VBD cord-005453-4057qib7 13952 26 first first JJ cord-005453-4057qib7 13952 27 allogeneic allogeneic IN cord-005453-4057qib7 13952 28 bone bone NN cord-005453-4057qib7 13952 29 marrow marrow NN cord-005453-4057qib7 13952 30 transplantation transplantation NN cord-005453-4057qib7 13952 31 with with IN cord-005453-4057qib7 13952 32 UCB UCB NNP cord-005453-4057qib7 13952 33 from from IN cord-005453-4057qib7 13952 34 2/1999 2/1999 CD cord-005453-4057qib7 13952 35 until until IN cord-005453-4057qib7 13952 36 6/2013 6/2013 CD cord-005453-4057qib7 13952 37 were be VBD cord-005453-4057qib7 13952 38 retrospectively retrospectively RB cord-005453-4057qib7 13952 39 analyzed analyze VBN cord-005453-4057qib7 13952 40 . . . cord-005453-4057qib7 13953 1 Eighteen eighteen CD cord-005453-4057qib7 13953 2 had have VBD cord-005453-4057qib7 13953 3 malignant malignant JJ cord-005453-4057qib7 13953 4 disease disease NN cord-005453-4057qib7 13953 5 ( ( -LRB- cord-005453-4057qib7 13953 6 MD MD NNP cord-005453-4057qib7 13953 7 ) ) -RRB- cord-005453-4057qib7 13953 8 , , , cord-005453-4057qib7 13953 9 of of IN cord-005453-4057qib7 13953 10 whom whom WP cord-005453-4057qib7 13953 11 15 15 CD cord-005453-4057qib7 13953 12 in in IN cord-005453-4057qib7 13953 13 complete complete JJ cord-005453-4057qib7 13953 14 hematologic hematologic JJ cord-005453-4057qib7 13953 15 response response NN cord-005453-4057qib7 13953 16 , , , cord-005453-4057qib7 13953 17 and and CC cord-005453-4057qib7 13953 18 12 12 CD cord-005453-4057qib7 13953 19 non non JJ cord-005453-4057qib7 13953 20 malignant malignant JJ cord-005453-4057qib7 13953 21 disease disease NN cord-005453-4057qib7 13953 22 ( ( -LRB- cord-005453-4057qib7 13953 23 NMD NMD NNP cord-005453-4057qib7 13953 24 ) ) -RRB- cord-005453-4057qib7 13953 25 ( ( -LRB- cord-005453-4057qib7 13953 26 SCID SCID NNP cord-005453-4057qib7 13953 27 5 5 CD cord-005453-4057qib7 13953 28 , , , cord-005453-4057qib7 13953 29 chronic chronic JJ cord-005453-4057qib7 13953 30 granulomatous granulomatous JJ cord-005453-4057qib7 13953 31 disease disease NN cord-005453-4057qib7 13953 32 1 1 CD cord-005453-4057qib7 13953 33 , , , cord-005453-4057qib7 13953 34 severe severe JJ cord-005453-4057qib7 13953 35 aplastic aplastic JJ cord-005453-4057qib7 13953 36 anemia anemia NN cord-005453-4057qib7 13953 37 2 2 CD cord-005453-4057qib7 13953 38 , , , cord-005453-4057qib7 13953 39 s. s. NNP cord-005453-4057qib7 13954 1 Kostmann Kostmann NNP cord-005453-4057qib7 13954 2 1 1 CD cord-005453-4057qib7 13954 3 , , , cord-005453-4057qib7 13954 4 osteopetrosis osteopetrosis NN cord-005453-4057qib7 13954 5 1 1 CD cord-005453-4057qib7 13954 6 , , , cord-005453-4057qib7 13954 7 Wiskott Wiskott NNP cord-005453-4057qib7 13954 8 - - HYPH cord-005453-4057qib7 13954 9 Aldrich1 Aldrich1 NNP cord-005453-4057qib7 13954 10 , , , cord-005453-4057qib7 13954 11 amegakaryocytic amegakaryocytic JJ cord-005453-4057qib7 13954 12 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 13954 13 1 1 CD cord-005453-4057qib7 13954 14 ) ) -RRB- cord-005453-4057qib7 13954 15 . . . cord-005453-4057qib7 13955 1 The the DT cord-005453-4057qib7 13955 2 majority majority NN cord-005453-4057qib7 13955 3 of of IN cord-005453-4057qib7 13955 4 the the DT cord-005453-4057qib7 13955 5 patients patient NNS cord-005453-4057qib7 13955 6 were be VBD cord-005453-4057qib7 13955 7 male male JJ cord-005453-4057qib7 13955 8 , , , cord-005453-4057qib7 13955 9 for for IN cord-005453-4057qib7 13955 10 MD MD NNP cord-005453-4057qib7 13955 11 and and CC cord-005453-4057qib7 13955 12 NMD NMD NNP cord-005453-4057qib7 13955 13 , , , cord-005453-4057qib7 13955 14 as as RB cord-005453-4057qib7 13955 15 well well RB cord-005453-4057qib7 13955 16 ( ( -LRB- cord-005453-4057qib7 13955 17 M:10 M:10 NNP cord-005453-4057qib7 13955 18 / / SYM cord-005453-4057qib7 13955 19 F:8 F:8 NNP cord-005453-4057qib7 13955 20 , , , cord-005453-4057qib7 13955 21 M:8 M:8 NNP cord-005453-4057qib7 13955 22 / / SYM cord-005453-4057qib7 13955 23 F:4 F:4 NNP cord-005453-4057qib7 13955 24 , , , cord-005453-4057qib7 13955 25 respectively respectively RB cord-005453-4057qib7 13955 26 ) ) -RRB- cord-005453-4057qib7 13955 27 , , , cord-005453-4057qib7 13955 28 of of IN cord-005453-4057qib7 13955 29 median median JJ cord-005453-4057qib7 13955 30 age age NN cord-005453-4057qib7 13955 31 6.5 6.5 CD cord-005453-4057qib7 13955 32 years year NNS cord-005453-4057qib7 13955 33 ( ( -LRB- cord-005453-4057qib7 13955 34 range range VBP cord-005453-4057qib7 13955 35 0.8 0.8 CD cord-005453-4057qib7 13955 36 - - HYPH cord-005453-4057qib7 13955 37 11.8 11.8 CD cord-005453-4057qib7 13955 38 years year NNS cord-005453-4057qib7 13955 39 ) ) -RRB- cord-005453-4057qib7 13955 40 and and CC cord-005453-4057qib7 13955 41 0.8 0.8 CD cord-005453-4057qib7 13955 42 years year NNS cord-005453-4057qib7 13955 43 ( ( -LRB- cord-005453-4057qib7 13955 44 range range VBP cord-005453-4057qib7 13955 45 0.4 0.4 CD cord-005453-4057qib7 13955 46 - - SYM cord-005453-4057qib7 13955 47 6.5 6.5 CD cord-005453-4057qib7 13955 48 years year NNS cord-005453-4057qib7 13955 49 ) ) -RRB- cord-005453-4057qib7 13955 50 , , . cord-005453-4057qib7 13956 1 respectively respectively RB cord-005453-4057qib7 13956 2 Results result VBZ cord-005453-4057qib7 13956 3 : : : cord-005453-4057qib7 13957 1 All all DT cord-005453-4057qib7 13957 2 patients patient NNS cord-005453-4057qib7 13957 3 but but CC cord-005453-4057qib7 13957 4 one one CD cord-005453-4057qib7 13957 5 , , , cord-005453-4057qib7 13957 6 received receive VBD cord-005453-4057qib7 13957 7 1 1 CD cord-005453-4057qib7 13957 8 UCB UCB NNP cord-005453-4057qib7 13957 9 unit unit NN cord-005453-4057qib7 13957 10 . . . cord-005453-4057qib7 13958 1 HLA HLA NNP cord-005453-4057qib7 13958 2 compatibility compatibility NN cord-005453-4057qib7 13958 3 in in IN cord-005453-4057qib7 13958 4 antigen antigen NN cord-005453-4057qib7 13958 5 / / SYM cord-005453-4057qib7 13958 6 allele allele NN cord-005453-4057qib7 13958 7 level level NN cord-005453-4057qib7 13958 8 was be VBD cord-005453-4057qib7 13958 9 at at IN cord-005453-4057qib7 13958 10 least least JJS cord-005453-4057qib7 13958 11 5/6 5/6 CD cord-005453-4057qib7 13958 12 and and CC cord-005453-4057qib7 13958 13 only only RB cord-005453-4057qib7 13958 14 in in IN cord-005453-4057qib7 13958 15 3 3 CD cord-005453-4057qib7 13958 16 patients patient NNS cord-005453-4057qib7 13958 17 with with IN cord-005453-4057qib7 13958 18 MD MD NNP cord-005453-4057qib7 13958 19 was be VBD cord-005453-4057qib7 13958 20 4/6 4/6 CD cord-005453-4057qib7 13958 21 . . . cord-005453-4057qib7 13959 1 Conditioning conditioning NN cord-005453-4057qib7 13959 2 regimens regimen NNS cord-005453-4057qib7 13959 3 were be VBD cord-005453-4057qib7 13959 4 myeloablative myeloablative JJ cord-005453-4057qib7 13959 5 and and CC cord-005453-4057qib7 13959 6 TBI TBI NNP cord-005453-4057qib7 13959 7 12 12 CD cord-005453-4057qib7 13959 8 Gy Gy NNP cord-005453-4057qib7 13959 9 was be VBD cord-005453-4057qib7 13959 10 given give VBN cord-005453-4057qib7 13959 11 in in IN cord-005453-4057qib7 13959 12 4/30 4/30 CD cord-005453-4057qib7 13959 13 . . . cord-005453-4057qib7 13960 1 GVHD GVHD NNP cord-005453-4057qib7 13960 2 prophylaxis prophylaxis NN cord-005453-4057qib7 13960 3 consisted consist VBD cord-005453-4057qib7 13960 4 of of IN cord-005453-4057qib7 13960 5 cyclosporine cyclosporine NN cord-005453-4057qib7 13960 6 and and CC cord-005453-4057qib7 13960 7 ATG ATG NNP cord-005453-4057qib7 13960 8 was be VBD cord-005453-4057qib7 13960 9 given give VBN cord-005453-4057qib7 13960 10 in in IN cord-005453-4057qib7 13960 11 all all DT cord-005453-4057qib7 13960 12 patients patient NNS cord-005453-4057qib7 13960 13 pre pre JJ cord-005453-4057qib7 13960 14 - - NN cord-005453-4057qib7 13960 15 transplantation transplantation NN cord-005453-4057qib7 13960 16 . . . cord-005453-4057qib7 13961 1 Median median JJ cord-005453-4057qib7 13961 2 value value NN cord-005453-4057qib7 13961 3 of of IN cord-005453-4057qib7 13961 4 nucleated nucleated JJ cord-005453-4057qib7 13961 5 cells cell NNS cord-005453-4057qib7 13961 6 for for IN cord-005453-4057qib7 13961 7 MD MD NNP cord-005453-4057qib7 13961 8 was be VBD cord-005453-4057qib7 13961 9 3.75χ10 3.75χ10 CD cord-005453-4057qib7 13961 10 7 7 CD cord-005453-4057qib7 13961 11 /kg /kg . cord-005453-4057qib7 13962 1 ( ( -LRB- cord-005453-4057qib7 13962 2 range range NNP cord-005453-4057qib7 13962 3 2 2 CD cord-005453-4057qib7 13962 4 - - HYPH cord-005453-4057qib7 13962 5 6.3χ10 6.3χ10 CD cord-005453-4057qib7 13962 6 7 7 CD cord-005453-4057qib7 13962 7 / / SYM cord-005453-4057qib7 13962 8 kg kg NNP cord-005453-4057qib7 13962 9 ) ) -RRB- cord-005453-4057qib7 13962 10 and and CC cord-005453-4057qib7 13962 11 for for IN cord-005453-4057qib7 13962 12 NMD NMD NNP cord-005453-4057qib7 13962 13 was be VBD cord-005453-4057qib7 13962 14 11.05χ10 11.05χ10 CD cord-005453-4057qib7 13962 15 7 7 CD cord-005453-4057qib7 13963 1 /kg /kg . cord-005453-4057qib7 13964 1 ( ( -LRB- cord-005453-4057qib7 13964 2 range range NNP cord-005453-4057qib7 13964 3 2 2 CD cord-005453-4057qib7 13964 4 - - HYPH cord-005453-4057qib7 13964 5 27.2χ10 27.2χ10 CD cord-005453-4057qib7 13964 6 7 7 CD cord-005453-4057qib7 13964 7 /kg /kg CD cord-005453-4057qib7 13964 8 ) ) -RRB- cord-005453-4057qib7 13964 9 . . . cord-005453-4057qib7 13965 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 13965 2 and and CC cord-005453-4057qib7 13965 3 platelet platelet NN cord-005453-4057qib7 13965 4 engraftment engraftment NN cord-005453-4057qib7 13965 5 was be VBD cord-005453-4057qib7 13965 6 achieved achieve VBN cord-005453-4057qib7 13965 7 in in IN cord-005453-4057qib7 13965 8 13/18 13/18 CD cord-005453-4057qib7 13965 9 and and CC cord-005453-4057qib7 13965 10 12/18 12/18 CD cord-005453-4057qib7 13965 11 patients patient NNS cord-005453-4057qib7 13965 12 with with IN cord-005453-4057qib7 13965 13 MD MD NNP cord-005453-4057qib7 13965 14 respectively respectively RB cord-005453-4057qib7 13965 15 , , , cord-005453-4057qib7 13965 16 in in IN cord-005453-4057qib7 13965 17 a a DT cord-005453-4057qib7 13965 18 median median JJ cord-005453-4057qib7 13965 19 time time NN cord-005453-4057qib7 13965 20 of of IN cord-005453-4057qib7 13965 21 31 31 CD cord-005453-4057qib7 13965 22 days day NNS cord-005453-4057qib7 13965 23 ( ( -LRB- cord-005453-4057qib7 13965 24 range range VBP cord-005453-4057qib7 13965 25 17 17 CD cord-005453-4057qib7 13965 26 - - SYM cord-005453-4057qib7 13965 27 44 44 CD cord-005453-4057qib7 13965 28 ) ) -RRB- cord-005453-4057qib7 13965 29 και και VBP cord-005453-4057qib7 13965 30 43 43 CD cord-005453-4057qib7 13965 31 days day NNS cord-005453-4057qib7 13965 32 ( ( -LRB- cord-005453-4057qib7 13965 33 range range VBP cord-005453-4057qib7 13965 34 20 20 CD cord-005453-4057qib7 13965 35 - - SYM cord-005453-4057qib7 13965 36 60 60 CD cord-005453-4057qib7 13965 37 ) ) -RRB- cord-005453-4057qib7 13965 38 . . . cord-005453-4057qib7 13966 1 In in IN cord-005453-4057qib7 13966 2 patients patient NNS cord-005453-4057qib7 13966 3 with with IN cord-005453-4057qib7 13966 4 NMD NMD NNP cord-005453-4057qib7 13966 5 , , , cord-005453-4057qib7 13966 6 neutrophil neutrophil NN cord-005453-4057qib7 13966 7 and and CC cord-005453-4057qib7 13966 8 platelet platelet NN cord-005453-4057qib7 13966 9 engraftment engraftment NN cord-005453-4057qib7 13966 10 was be VBD cord-005453-4057qib7 13966 11 achieved achieve VBN cord-005453-4057qib7 13966 12 in in IN cord-005453-4057qib7 13966 13 7/12 7/12 CD cord-005453-4057qib7 13966 14 and and CC cord-005453-4057qib7 13966 15 6/12 6/12 CD cord-005453-4057qib7 13966 16 with with IN cord-005453-4057qib7 13966 17 median median JJ cord-005453-4057qib7 13966 18 day day NN cord-005453-4057qib7 13966 19 of of IN cord-005453-4057qib7 13966 20 engraftment engraftment NN cord-005453-4057qib7 13966 21 21 21 CD cord-005453-4057qib7 13966 22 days day NNS cord-005453-4057qib7 13966 23 ( ( -LRB- cord-005453-4057qib7 13966 24 range range VBP cord-005453-4057qib7 13966 25 18 18 CD cord-005453-4057qib7 13966 26 - - SYM cord-005453-4057qib7 13966 27 28 28 CD cord-005453-4057qib7 13966 28 ) ) -RRB- cord-005453-4057qib7 13966 29 και και VBP cord-005453-4057qib7 13966 30 29 29 CD cord-005453-4057qib7 13966 31 days day NNS cord-005453-4057qib7 13966 32 ( ( -LRB- cord-005453-4057qib7 13966 33 range range NN cord-005453-4057qib7 13966 34 respectively respectively RB cord-005453-4057qib7 13966 35 . . . cord-005453-4057qib7 13967 1 Acute acute JJ cord-005453-4057qib7 13967 2 GVHD GVHD NNP cord-005453-4057qib7 13967 3 grade grade NN cord-005453-4057qib7 13967 4 ΙΙ ΙΙ NNP cord-005453-4057qib7 13967 5 - - HYPH cord-005453-4057qib7 13967 6 ΙV ΙV NNP cord-005453-4057qib7 13967 7 presented present VBN cord-005453-4057qib7 13967 8 in in IN cord-005453-4057qib7 13967 9 9/18 9/18 CD cord-005453-4057qib7 13967 10 patients patient NNS cord-005453-4057qib7 13967 11 with with IN cord-005453-4057qib7 13967 12 MD MD NNP cord-005453-4057qib7 13967 13 and and CC cord-005453-4057qib7 13967 14 4/12 4/12 CD cord-005453-4057qib7 13967 15 with with IN cord-005453-4057qib7 13967 16 NMD NMD NNP cord-005453-4057qib7 13967 17 , , , cord-005453-4057qib7 13967 18 although although IN cord-005453-4057qib7 13967 19 none none NN cord-005453-4057qib7 13967 20 had have VBD cord-005453-4057qib7 13967 21 cGVHD cGVHD NNP cord-005453-4057qib7 13967 22 . . . cord-005453-4057qib7 13968 1 The the DT cord-005453-4057qib7 13968 2 incidence incidence NN cord-005453-4057qib7 13968 3 of of IN cord-005453-4057qib7 13968 4 viral viral JJ cord-005453-4057qib7 13968 5 infections infection NNS cord-005453-4057qib7 13968 6 was be VBD cord-005453-4057qib7 13968 7 22 22 CD cord-005453-4057qib7 13968 8 cases case NNS cord-005453-4057qib7 13968 9 in in IN cord-005453-4057qib7 13968 10 11 11 CD cord-005453-4057qib7 13968 11 patients patient NNS cord-005453-4057qib7 13968 12 with with IN cord-005453-4057qib7 13968 13 MD MD NNP cord-005453-4057qib7 13968 14 and and CC cord-005453-4057qib7 13968 15 9 9 CD cord-005453-4057qib7 13968 16 cases case NNS cord-005453-4057qib7 13968 17 in in IN cord-005453-4057qib7 13968 18 6 6 CD cord-005453-4057qib7 13968 19 patients patient NNS cord-005453-4057qib7 13968 20 with with IN cord-005453-4057qib7 13968 21 NMD NMD NNP cord-005453-4057qib7 13968 22 . . . cord-005453-4057qib7 13969 1 Disease Disease NNP cord-005453-4057qib7 13969 2 relapse relapse NN cord-005453-4057qib7 13969 3 occured occur VBD cord-005453-4057qib7 13969 4 in in IN cord-005453-4057qib7 13969 5 9/18 9/18 CD cord-005453-4057qib7 13969 6 patients patient NNS cord-005453-4057qib7 13969 7 with with IN cord-005453-4057qib7 13969 8 MD MD NNP cord-005453-4057qib7 13969 9 . . . cord-005453-4057qib7 13970 1 After after IN cord-005453-4057qib7 13970 2 a a DT cord-005453-4057qib7 13970 3 median median JJ cord-005453-4057qib7 13970 4 time time NN cord-005453-4057qib7 13970 5 of of IN cord-005453-4057qib7 13970 6 10 10 CD cord-005453-4057qib7 13970 7 years year NNS cord-005453-4057qib7 13970 8 follow follow VBP cord-005453-4057qib7 13970 9 up up RP cord-005453-4057qib7 13970 10 , , , cord-005453-4057qib7 13970 11 overall overall JJ cord-005453-4057qib7 13970 12 survival survival NN cord-005453-4057qib7 13970 13 ( ( -LRB- cord-005453-4057qib7 13970 14 OS OS NNP cord-005453-4057qib7 13970 15 ) ) -RRB- cord-005453-4057qib7 13970 16 and and CC cord-005453-4057qib7 13970 17 event event VB cord-005453-4057qib7 13970 18 free free JJ cord-005453-4057qib7 13970 19 survival survival NN cord-005453-4057qib7 13970 20 ( ( -LRB- cord-005453-4057qib7 13970 21 EFS EFS NNP cord-005453-4057qib7 13970 22 ) ) -RRB- cord-005453-4057qib7 13970 23 for for IN cord-005453-4057qib7 13970 24 children child NNS cord-005453-4057qib7 13970 25 with with IN cord-005453-4057qib7 13970 26 MD MD NNP cord-005453-4057qib7 13970 27 were be VBD cord-005453-4057qib7 13970 28 22 22 CD cord-005453-4057qib7 13970 29 % % NN cord-005453-4057qib7 13970 30 and and CC cord-005453-4057qib7 13970 31 18.5 18.5 CD cord-005453-4057qib7 13970 32 % % NN cord-005453-4057qib7 13970 33 respectively respectively RB cord-005453-4057qib7 13970 34 , , , cord-005453-4057qib7 13970 35 while while IN cord-005453-4057qib7 13970 36 for for IN cord-005453-4057qib7 13970 37 NMD NMD NNP cord-005453-4057qib7 13970 38 , , , cord-005453-4057qib7 13970 39 OS OS NNP cord-005453-4057qib7 13970 40 and and CC cord-005453-4057qib7 13970 41 EFS EFS NNP cord-005453-4057qib7 13970 42 were be VBD cord-005453-4057qib7 13970 43 33%.Treatment 33%.Treatment NNP cord-005453-4057qib7 13970 44 related relate VBN cord-005453-4057qib7 13970 45 mortality mortality NN cord-005453-4057qib7 13970 46 at at IN cord-005453-4057qib7 13970 47 d+100 d+100 NNS cord-005453-4057qib7 13970 48 was be VBD cord-005453-4057qib7 13970 49 8 8 CD cord-005453-4057qib7 13970 50 % % NN cord-005453-4057qib7 13970 51 for for IN cord-005453-4057qib7 13970 52 MD MD NNP cord-005453-4057qib7 13970 53 and and CC cord-005453-4057qib7 13970 54 50 50 CD cord-005453-4057qib7 13970 55 % % NN cord-005453-4057qib7 13970 56 for for IN cord-005453-4057qib7 13970 57 NMD NMD NNP cord-005453-4057qib7 13970 58 . . . cord-005453-4057qib7 13971 1 Among among IN cord-005453-4057qib7 13971 2 18 18 CD cord-005453-4057qib7 13971 3 patients patient NNS cord-005453-4057qib7 13971 4 with with IN cord-005453-4057qib7 13971 5 MD MD NNP cord-005453-4057qib7 13971 6 , , , cord-005453-4057qib7 13971 7 4 4 CD cord-005453-4057qib7 13971 8 are be VBP cord-005453-4057qib7 13971 9 still still RB cord-005453-4057qib7 13971 10 alive alive JJ cord-005453-4057qib7 13971 11 , , , cord-005453-4057qib7 13971 12 while while IN cord-005453-4057qib7 13971 13 the the DT cord-005453-4057qib7 13971 14 rest rest NN cord-005453-4057qib7 13971 15 died die VBD cord-005453-4057qib7 13971 16 from from IN cord-005453-4057qib7 13971 17 relapse relapse NN cord-005453-4057qib7 13971 18 ( ( -LRB- cord-005453-4057qib7 13971 19 n n NN cord-005453-4057qib7 13971 20 : : : cord-005453-4057qib7 13971 21 8) 8) NNP cord-005453-4057qib7 13971 22 , , , cord-005453-4057qib7 13971 23 viral viral JJ cord-005453-4057qib7 13971 24 infections infection NNS cord-005453-4057qib7 13972 1 ( ( -LRB- cord-005453-4057qib7 13972 2 n n NN cord-005453-4057qib7 13972 3 : : : cord-005453-4057qib7 13972 4 4 4 LS cord-005453-4057qib7 13972 5 ) ) -RRB- cord-005453-4057qib7 13972 6 , , , cord-005453-4057qib7 13972 7 septicemia septicemia NN cord-005453-4057qib7 13972 8 ( ( -LRB- cord-005453-4057qib7 13972 9 n n NN cord-005453-4057qib7 13972 10 : : : cord-005453-4057qib7 13972 11 1 1 CD cord-005453-4057qib7 13972 12 ) ) -RRB- cord-005453-4057qib7 13972 13 and and CC cord-005453-4057qib7 13972 14 aGVHD(n aGVHD(n NNP cord-005453-4057qib7 13972 15 : : : cord-005453-4057qib7 13972 16 1 1 CD cord-005453-4057qib7 13972 17 ) ) -RRB- cord-005453-4057qib7 13972 18 . . . cord-005453-4057qib7 13973 1 Among among IN cord-005453-4057qib7 13973 2 12 12 CD cord-005453-4057qib7 13973 3 patients patient NNS cord-005453-4057qib7 13973 4 with with IN cord-005453-4057qib7 13973 5 NMD NMD NNP cord-005453-4057qib7 13973 6 , , , cord-005453-4057qib7 13973 7 4 4 CD cord-005453-4057qib7 13973 8 are be VBP cord-005453-4057qib7 13973 9 alive alive JJ cord-005453-4057qib7 13973 10 , , , cord-005453-4057qib7 13973 11 while while IN cord-005453-4057qib7 13973 12 the the DT cord-005453-4057qib7 13973 13 rest rest NN cord-005453-4057qib7 13973 14 died die VBD cord-005453-4057qib7 13973 15 from from IN cord-005453-4057qib7 13973 16 viral viral JJ cord-005453-4057qib7 13973 17 infections infection NNS cord-005453-4057qib7 13973 18 ( ( -LRB- cord-005453-4057qib7 13973 19 n n NN cord-005453-4057qib7 13973 20 : : SYM cord-005453-4057qib7 13973 21 2 2 LS cord-005453-4057qib7 13973 22 ) ) -RRB- cord-005453-4057qib7 13973 23 , , , cord-005453-4057qib7 13973 24 septicemia septicemia NN cord-005453-4057qib7 13973 25 ( ( -LRB- cord-005453-4057qib7 13973 26 n:4 n:4 NNP cord-005453-4057qib7 13973 27 ) ) -RRB- cord-005453-4057qib7 13973 28 and and CC cord-005453-4057qib7 13973 29 multiple multiple JJ cord-005453-4057qib7 13973 30 organ organ NN cord-005453-4057qib7 13973 31 failure failure NN cord-005453-4057qib7 13973 32 ( ( -LRB- cord-005453-4057qib7 13973 33 n=2 n=2 NNS cord-005453-4057qib7 13973 34 ) ) -RRB- cord-005453-4057qib7 13973 35 . . . cord-005453-4057qib7 13974 1 The the DT cord-005453-4057qib7 13974 2 median median JJ cord-005453-4057qib7 13974 3 time time NN cord-005453-4057qib7 13974 4 of of IN cord-005453-4057qib7 13974 5 hospitalization hospitalization NN cord-005453-4057qib7 13974 6 for for IN cord-005453-4057qib7 13974 7 patients patient NNS cord-005453-4057qib7 13974 8 with with IN cord-005453-4057qib7 13974 9 MD MD NNP cord-005453-4057qib7 13974 10 was be VBD cord-005453-4057qib7 13974 11 76 76 CD cord-005453-4057qib7 13974 12 days day NNS cord-005453-4057qib7 13975 1 ( ( -LRB- cord-005453-4057qib7 13975 2 range range NNP cord-005453-4057qib7 13975 3 32 32 CD cord-005453-4057qib7 13975 4 - - SYM cord-005453-4057qib7 13975 5 168 168 CD cord-005453-4057qib7 13975 6 ) ) -RRB- cord-005453-4057qib7 13975 7 , , , cord-005453-4057qib7 13975 8 whilst whilst IN cord-005453-4057qib7 13975 9 for for IN cord-005453-4057qib7 13975 10 NMD NMD NNP cord-005453-4057qib7 13975 11 was be VBD cord-005453-4057qib7 13975 12 63 63 CD cord-005453-4057qib7 13975 13 days day NNS cord-005453-4057qib7 13975 14 ( ( -LRB- cord-005453-4057qib7 13975 15 range range NNP cord-005453-4057qib7 13975 16 28 28 CD cord-005453-4057qib7 13975 17 - - SYM cord-005453-4057qib7 13975 18 114 114 CD cord-005453-4057qib7 13975 19 ) ) -RRB- cord-005453-4057qib7 13975 20 . . . cord-005453-4057qib7 13976 1 Conclusions conclusion NNS cord-005453-4057qib7 13976 2 : : : cord-005453-4057qib7 13977 1 Transplantation transplantation NN cord-005453-4057qib7 13977 2 of of IN cord-005453-4057qib7 13977 3 unrelated unrelated JJ cord-005453-4057qib7 13977 4 UCB UCB NNP cord-005453-4057qib7 13977 5 in in IN cord-005453-4057qib7 13977 6 our -PRON- PRP$ cord-005453-4057qib7 13977 7 unit unit NN cord-005453-4057qib7 13977 8 was be VBD cord-005453-4057qib7 13977 9 combined combine VBN cord-005453-4057qib7 13977 10 with with IN cord-005453-4057qib7 13977 11 high high JJ cord-005453-4057qib7 13977 12 TRM TRM NNP cord-005453-4057qib7 13977 13 in in IN cord-005453-4057qib7 13977 14 children child NNS cord-005453-4057qib7 13977 15 with with IN cord-005453-4057qib7 13977 16 NMD NMD NNP cord-005453-4057qib7 13977 17 and and CC cord-005453-4057qib7 13977 18 higher high JJR cord-005453-4057qib7 13977 19 probability probability NN cord-005453-4057qib7 13977 20 of of IN cord-005453-4057qib7 13977 21 relapse relapse NN cord-005453-4057qib7 13977 22 for for IN cord-005453-4057qib7 13977 23 MD MD NNP cord-005453-4057qib7 13977 24 . . . cord-005453-4057qib7 13978 1 Disclosure disclosure NN cord-005453-4057qib7 13978 2 : : : cord-005453-4057qib7 13978 3 Nothing nothing NN cord-005453-4057qib7 13978 4 to to TO cord-005453-4057qib7 13978 5 declare declare VB cord-005453-4057qib7 13978 6 P643 P643 NNP cord-005453-4057qib7 13978 7 Serum serum NN cord-005453-4057qib7 13978 8 levels level NNS cord-005453-4057qib7 13978 9 of of IN cord-005453-4057qib7 13978 10 5-S 5-S NNP cord-005453-4057qib7 13978 11 cysteinyldopa cysteinyldopa NN cord-005453-4057qib7 13978 12 is be VBZ cord-005453-4057qib7 13978 13 associated associate VBN cord-005453-4057qib7 13978 14 with with IN cord-005453-4057qib7 13978 15 stem stem NN cord-005453-4057qib7 13978 16 cell cell NN cord-005453-4057qib7 13978 17 transplantation transplantation NN cord-005453-4057qib7 13978 18 related relate VBN cord-005453-4057qib7 13978 19 complications complication NNS cord-005453-4057qib7 13978 20 Yukayo Yukayo NNP cord-005453-4057qib7 13978 21 Terashita Terashita NNP cord-005453-4057qib7 13978 22 1 1 CD cord-005453-4057qib7 13978 23 , , , cord-005453-4057qib7 13978 24 Mamoru Mamoru NNP cord-005453-4057qib7 13978 25 Honda Honda NNP cord-005453-4057qib7 13978 26 1 1 CD cord-005453-4057qib7 13978 27 , , , cord-005453-4057qib7 13978 28 Minako Minako NNP cord-005453-4057qib7 13978 29 Sugiyama Sugiyama NNP cord-005453-4057qib7 13978 30 1 1 CD cord-005453-4057qib7 13978 31 , , , cord-005453-4057qib7 13978 32 Yuko Yuko NNP cord-005453-4057qib7 13978 33 Cho Cho NNP cord-005453-4057qib7 13978 34 1 1 CD cord-005453-4057qib7 13978 35 , , , cord-005453-4057qib7 13978 36 Akihiro Akihiro NNP cord-005453-4057qib7 13978 37 Iguchi Iguchi NNP cord-005453-4057qib7 13979 1 1 1 CD cord-005453-4057qib7 13979 2 1 1 CD cord-005453-4057qib7 13979 3 Hokkaido Hokkaido NNP cord-005453-4057qib7 13979 4 University University NNP cord-005453-4057qib7 13979 5 Hospital Hospital NNP cord-005453-4057qib7 13979 6 , , , cord-005453-4057qib7 13979 7 Pediatrics Pediatrics NNP cord-005453-4057qib7 13979 8 , , , cord-005453-4057qib7 13979 9 Sapporo Sapporo NNP cord-005453-4057qib7 13979 10 , , , cord-005453-4057qib7 13979 11 Japan Japan NNP cord-005453-4057qib7 13979 12 Background Background NNP cord-005453-4057qib7 13979 13 : : : cord-005453-4057qib7 13980 1 Diffuse diffuse JJ cord-005453-4057qib7 13980 2 hyperpigmentation hyperpigmentation NN cord-005453-4057qib7 13980 3 is be VBZ cord-005453-4057qib7 13980 4 common common JJ cord-005453-4057qib7 13980 5 in in IN cord-005453-4057qib7 13980 6 patients patient NNS cord-005453-4057qib7 13980 7 who who WP cord-005453-4057qib7 13980 8 received receive VBD cord-005453-4057qib7 13980 9 chemotherapy chemotherapy NN cord-005453-4057qib7 13980 10 or or CC cord-005453-4057qib7 13980 11 stem stem NN cord-005453-4057qib7 13980 12 cell cell NN cord-005453-4057qib7 13980 13 transplantation transplantation NN cord-005453-4057qib7 13980 14 ( ( -LRB- cord-005453-4057qib7 13980 15 SCT SCT NNP cord-005453-4057qib7 13980 16 ) ) -RRB- cord-005453-4057qib7 13980 17 . . . cord-005453-4057qib7 13981 1 However however RB cord-005453-4057qib7 13981 2 , , , cord-005453-4057qib7 13981 3 there there EX cord-005453-4057qib7 13981 4 are be VBP cord-005453-4057qib7 13981 5 few few JJ cord-005453-4057qib7 13981 6 reports report NNS cord-005453-4057qib7 13981 7 of of IN cord-005453-4057qib7 13981 8 the the DT cord-005453-4057qib7 13981 9 relationship relationship NN cord-005453-4057qib7 13981 10 between between IN cord-005453-4057qib7 13981 11 skin skin NN cord-005453-4057qib7 13981 12 reaction reaction NN cord-005453-4057qib7 13981 13 such such JJ cord-005453-4057qib7 13981 14 as as IN cord-005453-4057qib7 13981 15 pigmentation pigmentation NN cord-005453-4057qib7 13981 16 and and CC cord-005453-4057qib7 13981 17 the the DT cord-005453-4057qib7 13981 18 other other JJ cord-005453-4057qib7 13981 19 complications complication NNS cord-005453-4057qib7 13981 20 . . . cord-005453-4057qib7 13982 1 Pigmentation pigmentation NN cord-005453-4057qib7 13982 2 of of IN cord-005453-4057qib7 13982 3 the the DT cord-005453-4057qib7 13982 4 skin skin NN cord-005453-4057qib7 13982 5 is be VBZ cord-005453-4057qib7 13982 6 thought think VBN cord-005453-4057qib7 13982 7 to to TO cord-005453-4057qib7 13982 8 be be VB cord-005453-4057qib7 13982 9 the the DT cord-005453-4057qib7 13982 10 result result NN cord-005453-4057qib7 13982 11 of of IN cord-005453-4057qib7 13982 12 melanin melanin NN cord-005453-4057qib7 13982 13 stagnating stagnate VBG cord-005453-4057qib7 13982 14 in in IN cord-005453-4057qib7 13982 15 the the DT cord-005453-4057qib7 13982 16 dermic dermic NN cord-005453-4057qib7 13982 17 layer layer NN cord-005453-4057qib7 13982 18 due due JJ cord-005453-4057qib7 13982 19 to to IN cord-005453-4057qib7 13982 20 increased increase VBN cord-005453-4057qib7 13982 21 synthesis synthesis NN cord-005453-4057qib7 13982 22 of of IN cord-005453-4057qib7 13982 23 melanin melanin NN cord-005453-4057qib7 13982 24 and and CC cord-005453-4057qib7 13982 25 destruction destruction NN cord-005453-4057qib7 13982 26 of of IN cord-005453-4057qib7 13982 27 the the DT cord-005453-4057qib7 13982 28 basement basement NN cord-005453-4057qib7 13982 29 membrane membrane NN cord-005453-4057qib7 13982 30 due due IN cord-005453-4057qib7 13982 31 to to IN cord-005453-4057qib7 13982 32 inflammation inflammation NN cord-005453-4057qib7 13982 33 induced induce VBN cord-005453-4057qib7 13982 34 chemoradiotherapy chemoradiotherapy NN cord-005453-4057qib7 13982 35 . . . cord-005453-4057qib7 13983 1 Melanin melanin NN cord-005453-4057qib7 13983 2 pigments pigment NNS cord-005453-4057qib7 13983 3 are be VBP cord-005453-4057qib7 13983 4 classified classify VBN cord-005453-4057qib7 13983 5 into into IN cord-005453-4057qib7 13983 6 two two CD cord-005453-4057qib7 13983 7 types type NNS cord-005453-4057qib7 13983 8 : : : cord-005453-4057qib7 13983 9 brown brown JJ cord-005453-4057qib7 13983 10 to to IN cord-005453-4057qib7 13983 11 black black JJ cord-005453-4057qib7 13983 12 eumelanin eumelanin NNS cord-005453-4057qib7 13983 13 and and CC cord-005453-4057qib7 13983 14 yellow yellow JJ cord-005453-4057qib7 13983 15 to to IN cord-005453-4057qib7 13983 16 reddishbrown reddishbrown JJ cord-005453-4057qib7 13983 17 pheomelanin pheomelanin NNS cord-005453-4057qib7 13983 18 . . . cord-005453-4057qib7 13984 1 5-S 5-S NNP cord-005453-4057qib7 13984 2 Cysteinyldopa Cysteinyldopa NNP cord-005453-4057qib7 13984 3 ( ( -LRB- cord-005453-4057qib7 13984 4 5SCD 5scd NN cord-005453-4057qib7 13984 5 ) ) -RRB- cord-005453-4057qib7 13984 6 is be VBZ cord-005453-4057qib7 13984 7 precursors precursor NNS cord-005453-4057qib7 13984 8 of of IN cord-005453-4057qib7 13984 9 pheomelanin pheomelanin NNS cord-005453-4057qib7 13984 10 , , , cord-005453-4057qib7 13984 11 and and CC cord-005453-4057qib7 13984 12 its -PRON- PRP$ cord-005453-4057qib7 13984 13 serum serum NN cord-005453-4057qib7 13984 14 level level NN cord-005453-4057qib7 13984 15 has have VBZ cord-005453-4057qib7 13984 16 been be VBN cord-005453-4057qib7 13984 17 used use VBN cord-005453-4057qib7 13984 18 specific specific JJ cord-005453-4057qib7 13984 19 biochemical biochemical JJ cord-005453-4057qib7 13984 20 marker marker NN cord-005453-4057qib7 13984 21 for for IN cord-005453-4057qib7 13984 22 malignant malignant JJ cord-005453-4057qib7 13984 23 melanoma melanoma NN cord-005453-4057qib7 13984 24 . . . cord-005453-4057qib7 13985 1 Here here RB cord-005453-4057qib7 13985 2 , , , cord-005453-4057qib7 13985 3 we -PRON- PRP cord-005453-4057qib7 13985 4 examined examine VBD cord-005453-4057qib7 13985 5 serially serially RB cord-005453-4057qib7 13985 6 5SCD 5scd JJ cord-005453-4057qib7 13985 7 during during IN cord-005453-4057qib7 13985 8 the the DT cord-005453-4057qib7 13985 9 course course NN cord-005453-4057qib7 13985 10 of of IN cord-005453-4057qib7 13985 11 SCT SCT NNP cord-005453-4057qib7 13985 12 to to TO cord-005453-4057qib7 13985 13 determine determine VB cord-005453-4057qib7 13985 14 association association NN cord-005453-4057qib7 13985 15 with with IN cord-005453-4057qib7 13985 16 SCT SCT NNP cord-005453-4057qib7 13985 17 related relate VBN cord-005453-4057qib7 13985 18 complications complication NNS cord-005453-4057qib7 13985 19 , , , cord-005453-4057qib7 13985 20 because because IN cord-005453-4057qib7 13985 21 visual visual JJ cord-005453-4057qib7 13985 22 evaluation evaluation NN cord-005453-4057qib7 13985 23 of of IN cord-005453-4057qib7 13985 24 skin skin NN cord-005453-4057qib7 13985 25 color color NN cord-005453-4057qib7 13985 26 is be VBZ cord-005453-4057qib7 13985 27 difficult difficult JJ cord-005453-4057qib7 13985 28 , , , cord-005453-4057qib7 13985 29 and and CC cord-005453-4057qib7 13985 30 there there EX cord-005453-4057qib7 13985 31 have have VBP cord-005453-4057qib7 13985 32 been be VBN cord-005453-4057qib7 13985 33 no no DT cord-005453-4057qib7 13985 34 reports report NNS cord-005453-4057qib7 13985 35 about about IN cord-005453-4057qib7 13985 36 5SCD 5scd CD cord-005453-4057qib7 13985 37 as as IN cord-005453-4057qib7 13985 38 SCT SCT NNP cord-005453-4057qib7 13985 39 related relate VBN cord-005453-4057qib7 13985 40 biomarker biomarker NN cord-005453-4057qib7 13985 41 . . . cord-005453-4057qib7 13986 1 Methods method NNS cord-005453-4057qib7 13986 2 : : : cord-005453-4057qib7 13986 3 We -PRON- PRP cord-005453-4057qib7 13986 4 prospectively prospectively RB cord-005453-4057qib7 13986 5 analyzed analyze VBD cord-005453-4057qib7 13986 6 41(27 41(27 CD cord-005453-4057qib7 13986 7 males male NNS cord-005453-4057qib7 13986 8 , , , cord-005453-4057qib7 13986 9 14 14 CD cord-005453-4057qib7 13986 10 females female NNS cord-005453-4057qib7 13986 11 ) ) -RRB- cord-005453-4057qib7 13986 12 patients patient NNS cord-005453-4057qib7 13986 13 who who WP cord-005453-4057qib7 13986 14 received receive VBD cord-005453-4057qib7 13986 15 SCT SCT NNP cord-005453-4057qib7 13986 16 between between IN cord-005453-4057qib7 13986 17 May May NNP cord-005453-4057qib7 13986 18 2011 2011 CD cord-005453-4057qib7 13986 19 and and CC cord-005453-4057qib7 13986 20 March March NNP cord-005453-4057qib7 13986 21 2015 2015 CD cord-005453-4057qib7 13986 22 in in IN cord-005453-4057qib7 13986 23 Hokkaido Hokkaido NNP cord-005453-4057qib7 13986 24 University University NNP cord-005453-4057qib7 13986 25 Hospital Hospital NNP cord-005453-4057qib7 13986 26 . . . cord-005453-4057qib7 13987 1 The the DT cord-005453-4057qib7 13987 2 median median JJ cord-005453-4057qib7 13987 3 age age NN cord-005453-4057qib7 13987 4 at at IN cord-005453-4057qib7 13987 5 transplantation transplantation NN cord-005453-4057qib7 13987 6 of of IN cord-005453-4057qib7 13987 7 the the DT cord-005453-4057qib7 13987 8 patients patient NNS cord-005453-4057qib7 13987 9 was be VBD cord-005453-4057qib7 13987 10 7.9 7.9 CD cord-005453-4057qib7 13987 11 years year NNS cord-005453-4057qib7 13987 12 ( ( -LRB- cord-005453-4057qib7 13987 13 range range NN cord-005453-4057qib7 13987 14 , , , cord-005453-4057qib7 13987 15 0 0 CD cord-005453-4057qib7 13987 16 - - SYM cord-005453-4057qib7 13987 17 22 22 CD cord-005453-4057qib7 13987 18 ) ) -RRB- cord-005453-4057qib7 13987 19 . . . cord-005453-4057qib7 13988 1 Indication indication NN cord-005453-4057qib7 13988 2 for for IN cord-005453-4057qib7 13988 3 SCT SCT NNP cord-005453-4057qib7 13988 4 were be VBD cord-005453-4057qib7 13988 5 acute acute JJ cord-005453-4057qib7 13988 6 myelogenous myelogenous NN cord-005453-4057qib7 13988 7 leukemia leukemia NN cord-005453-4057qib7 13988 8 in in IN cord-005453-4057qib7 13988 9 10 10 CD cord-005453-4057qib7 13988 10 patients patient NNS cord-005453-4057qib7 13988 11 , , , cord-005453-4057qib7 13988 12 acute acute JJ cord-005453-4057qib7 13988 13 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 13988 14 leukemia leukemia NN cord-005453-4057qib7 13988 15 in in IN cord-005453-4057qib7 13988 16 9 9 CD cord-005453-4057qib7 13988 17 patients patient NNS cord-005453-4057qib7 13988 18 , , , cord-005453-4057qib7 13988 19 and and CC cord-005453-4057qib7 13988 20 other other JJ cord-005453-4057qib7 13988 21 disease disease NN cord-005453-4057qib7 13988 22 in in IN cord-005453-4057qib7 13988 23 22 22 CD cord-005453-4057qib7 13988 24 patients patient NNS cord-005453-4057qib7 13988 25 ; ; : cord-005453-4057qib7 13988 26 juvenile juvenile JJ cord-005453-4057qib7 13988 27 myelomonocytic myelomonocytic NN cord-005453-4057qib7 13988 28 leukemia(2 leukemia(2 NNP cord-005453-4057qib7 13988 29 ) ) -RRB- cord-005453-4057qib7 13988 30 , , , cord-005453-4057qib7 13988 31 malignant malignant JJ cord-005453-4057qib7 13988 32 solid solid JJ cord-005453-4057qib7 13988 33 tumor(11 tumor(11 NNP cord-005453-4057qib7 13988 34 ) ) -RRB- cord-005453-4057qib7 13988 35 , , , cord-005453-4057qib7 13988 36 immunodeficiency(6 immunodeficiency(6 NN cord-005453-4057qib7 13988 37 ) ) -RRB- cord-005453-4057qib7 13988 38 , , , cord-005453-4057qib7 13988 39 anaplastic anaplastic JJ cord-005453-4057qib7 13988 40 anemia(2 anemia(2 IN cord-005453-4057qib7 13988 41 ) ) -RRB- cord-005453-4057qib7 13988 42 , , , cord-005453-4057qib7 13988 43 and and CC cord-005453-4057qib7 13988 44 Diamond Diamond NNP cord-005453-4057qib7 13988 45 Blackfan Blackfan NNP cord-005453-4057qib7 13988 46 anemia anemia NN cord-005453-4057qib7 13988 47 ( ( -LRB- cord-005453-4057qib7 13988 48 1 1 CD cord-005453-4057qib7 13988 49 ) ) -RRB- cord-005453-4057qib7 13988 50 . . . cord-005453-4057qib7 13989 1 34 34 CD cord-005453-4057qib7 13989 2 patients patient NNS cord-005453-4057qib7 13989 3 received receive VBD cord-005453-4057qib7 13989 4 allogeneic allogeneic IN cord-005453-4057qib7 13989 5 SCT SCT NNP cord-005453-4057qib7 13989 6 and and CC cord-005453-4057qib7 13989 7 7 7 CD cord-005453-4057qib7 13989 8 received receive VBD cord-005453-4057qib7 13989 9 autologous autologous JJ cord-005453-4057qib7 13989 10 SCT SCT NNP cord-005453-4057qib7 13989 11 . . . cord-005453-4057qib7 13990 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 13990 2 conditioning conditioning NN cord-005453-4057qib7 13990 3 ( ( -LRB- cord-005453-4057qib7 13990 4 MAC MAC NNP cord-005453-4057qib7 13990 5 ) ) -RRB- cord-005453-4057qib7 13990 6 was be VBD cord-005453-4057qib7 13990 7 used use VBN cord-005453-4057qib7 13990 8 for for IN cord-005453-4057qib7 13990 9 30 30 CD cord-005453-4057qib7 13990 10 patients patient NNS cord-005453-4057qib7 13990 11 and and CC cord-005453-4057qib7 13990 12 reduced reduced JJ cord-005453-4057qib7 13990 13 intensity intensity NN cord-005453-4057qib7 13990 14 conditioning conditioning NN cord-005453-4057qib7 13990 15 ( ( -LRB- cord-005453-4057qib7 13990 16 RIC RIC NNP cord-005453-4057qib7 13990 17 ) ) -RRB- cord-005453-4057qib7 13990 18 was be VBD cord-005453-4057qib7 13990 19 used use VBN cord-005453-4057qib7 13990 20 for for IN cord-005453-4057qib7 13990 21 11 11 CD cord-005453-4057qib7 13990 22 patients patient NNS cord-005453-4057qib7 13990 23 . . . cord-005453-4057qib7 13991 1 Sera Sera NNP cord-005453-4057qib7 13991 2 were be VBD cord-005453-4057qib7 13991 3 obtained obtain VBN cord-005453-4057qib7 13991 4 from from IN cord-005453-4057qib7 13991 5 patients patient NNS cord-005453-4057qib7 13991 6 before before IN cord-005453-4057qib7 13991 7 conditioning conditioning NN cord-005453-4057qib7 13991 8 therapy therapy NN cord-005453-4057qib7 13991 9 , , , cord-005453-4057qib7 13991 10 on on IN cord-005453-4057qib7 13991 11 day day NN cord-005453-4057qib7 13991 12 0 0 CD cord-005453-4057qib7 13991 13 , , , cord-005453-4057qib7 13991 14 +5 +5 NN cord-005453-4057qib7 13991 15 , , , cord-005453-4057qib7 13991 16 +10 +10 CD cord-005453-4057qib7 13991 17 , , , cord-005453-4057qib7 13991 18 +15 +15 NNS cord-005453-4057qib7 13991 19 , , , cord-005453-4057qib7 13991 20 +25 +25 NNP cord-005453-4057qib7 13991 21 and and CC cord-005453-4057qib7 13991 22 +40 +40 NN cord-005453-4057qib7 13991 23 . . . cord-005453-4057qib7 13992 1 All all DT cord-005453-4057qib7 13992 2 blood blood NN cord-005453-4057qib7 13992 3 samples sample NNS cord-005453-4057qib7 13992 4 were be VBD cord-005453-4057qib7 13992 5 centrifuged centrifuge VBN cord-005453-4057qib7 13992 6 at at IN cord-005453-4057qib7 13992 7 3,000 3,000 CD cord-005453-4057qib7 13992 8 rpm rpm NN cord-005453-4057qib7 13992 9 for for IN cord-005453-4057qib7 13992 10 15 15 CD cord-005453-4057qib7 13992 11 min min NN cord-005453-4057qib7 13992 12 , , , cord-005453-4057qib7 13992 13 and and CC cord-005453-4057qib7 13992 14 stored store VBN cord-005453-4057qib7 13992 15 at at IN cord-005453-4057qib7 13992 16 -80˚C -80˚c NN cord-005453-4057qib7 13992 17 until until IN cord-005453-4057qib7 13992 18 used use VBN cord-005453-4057qib7 13992 19 . . . cord-005453-4057qib7 13993 1 We -PRON- PRP cord-005453-4057qib7 13993 2 also also RB cord-005453-4057qib7 13993 3 examined examine VBD cord-005453-4057qib7 13993 4 SCT SCT NNP cord-005453-4057qib7 13993 5 related relate VBN cord-005453-4057qib7 13993 6 complications complication NNS cord-005453-4057qib7 13993 7 such such JJ cord-005453-4057qib7 13993 8 as as IN cord-005453-4057qib7 13993 9 graft graft NN cord-005453-4057qib7 13993 10 - - HYPH cord-005453-4057qib7 13993 11 Versus versus IN cord-005453-4057qib7 13993 12 - - HYPH cord-005453-4057qib7 13993 13 host host NN cord-005453-4057qib7 13993 14 disease disease NN cord-005453-4057qib7 13993 15 ( ( -LRB- cord-005453-4057qib7 13993 16 GVHD GVHD NNP cord-005453-4057qib7 13993 17 ) ) -RRB- cord-005453-4057qib7 13993 18 , , , cord-005453-4057qib7 13993 19 viral viral JJ cord-005453-4057qib7 13993 20 infection infection NN cord-005453-4057qib7 13993 21 , , , cord-005453-4057qib7 13993 22 and and CC cord-005453-4057qib7 13993 23 pre pre JJ cord-005453-4057qib7 13993 24 - - JJ cord-005453-4057qib7 13993 25 engraft engraft JJ cord-005453-4057qib7 13993 26 syndrome syndrome NN cord-005453-4057qib7 13993 27 ( ( -LRB- cord-005453-4057qib7 13993 28 PES PES NNP cord-005453-4057qib7 13993 29 ) ) -RRB- cord-005453-4057qib7 13993 30 . . . cord-005453-4057qib7 13994 1 Statistical statistical JJ cord-005453-4057qib7 13994 2 analyses analysis NNS cord-005453-4057qib7 13994 3 were be VBD cord-005453-4057qib7 13994 4 completed complete VBN cord-005453-4057qib7 13994 5 using use VBG cord-005453-4057qib7 13994 6 the the DT cord-005453-4057qib7 13994 7 Mann Mann NNP cord-005453-4057qib7 13994 8 - - HYPH cord-005453-4057qib7 13994 9 Whitney Whitney NNP cord-005453-4057qib7 13994 10 U U NNP cord-005453-4057qib7 13994 11 test test VBP cord-005453-4057qib7 13994 12 for for IN cord-005453-4057qib7 13994 13 unpaired unpaired JJ cord-005453-4057qib7 13994 14 samples sample NNS cord-005453-4057qib7 13994 15 , , , cord-005453-4057qib7 13994 16 and and CC cord-005453-4057qib7 13994 17 Kruskal Kruskal NNP cord-005453-4057qib7 13994 18 - - HYPH cord-005453-4057qib7 13994 19 Wallis Wallis NNP cord-005453-4057qib7 13994 20 test test NN cord-005453-4057qib7 13994 21 for for IN cord-005453-4057qib7 13994 22 three three CD cord-005453-4057qib7 13994 23 samples sample NNS cord-005453-4057qib7 13994 24 . . . cord-005453-4057qib7 13995 1 Each each DT cord-005453-4057qib7 13995 2 test test NN cord-005453-4057qib7 13995 3 was be VBD cord-005453-4057qib7 13995 4 performed perform VBN cord-005453-4057qib7 13995 5 with with IN cord-005453-4057qib7 13995 6 a a DT cord-005453-4057qib7 13995 7 5 5 CD cord-005453-4057qib7 13995 8 % % NN cord-005453-4057qib7 13995 9 level level NN cord-005453-4057qib7 13995 10 of of IN cord-005453-4057qib7 13995 11 significance significance NN cord-005453-4057qib7 13995 12 . . . cord-005453-4057qib7 13996 1 Results result NNS cord-005453-4057qib7 13996 2 : : : cord-005453-4057qib7 13997 1 The the DT cord-005453-4057qib7 13997 2 average average JJ cord-005453-4057qib7 13997 3 value value NN cord-005453-4057qib7 13997 4 of of IN cord-005453-4057qib7 13997 5 5SCD 5scd RB cord-005453-4057qib7 13997 6 reached reach VBD cord-005453-4057qib7 13997 7 two two CD cord-005453-4057qib7 13997 8 peaks peak NNS cord-005453-4057qib7 13997 9 , , , cord-005453-4057qib7 13997 10 day0 day0 NN cord-005453-4057qib7 13997 11 ( ( -LRB- cord-005453-4057qib7 13997 12 21.6 21.6 CD cord-005453-4057qib7 13997 13 nmol nmol NNP cord-005453-4057qib7 13997 14 / / SYM cord-005453-4057qib7 13997 15 L L NNP cord-005453-4057qib7 13997 16 ) ) -RRB- cord-005453-4057qib7 13997 17 and and CC cord-005453-4057qib7 13997 18 day5 day5 NN cord-005453-4057qib7 13997 19 ( ( -LRB- cord-005453-4057qib7 13997 20 21.7 21.7 CD cord-005453-4057qib7 13997 21 nmol nmol NNP cord-005453-4057qib7 13997 22 / / SYM cord-005453-4057qib7 13997 23 L L NNP cord-005453-4057qib7 13997 24 ) ) -RRB- cord-005453-4057qib7 13997 25 , , , cord-005453-4057qib7 13997 26 regardless regardless RB cord-005453-4057qib7 13997 27 of of IN cord-005453-4057qib7 13997 28 stem stem NN cord-005453-4057qib7 13997 29 cell cell NN cord-005453-4057qib7 13997 30 source source NN cord-005453-4057qib7 13997 31 and and CC cord-005453-4057qib7 13997 32 intensity intensity NN cord-005453-4057qib7 13997 33 of of IN cord-005453-4057qib7 13997 34 conditioning conditioning NN cord-005453-4057qib7 13997 35 . . . cord-005453-4057qib7 13998 1 In in IN cord-005453-4057qib7 13998 2 all all DT cord-005453-4057qib7 13998 3 patients patient NNS cord-005453-4057qib7 13998 4 , , , cord-005453-4057qib7 13998 5 we -PRON- PRP cord-005453-4057qib7 13998 6 found find VBD cord-005453-4057qib7 13998 7 that that IN cord-005453-4057qib7 13998 8 the the DT cord-005453-4057qib7 13998 9 level level NN cord-005453-4057qib7 13998 10 of of IN cord-005453-4057qib7 13998 11 5SCD 5scd NN cord-005453-4057qib7 13998 12 on on IN cord-005453-4057qib7 13998 13 day0 day0 NNS cord-005453-4057qib7 13998 14 was be VBD cord-005453-4057qib7 13998 15 associated associate VBN cord-005453-4057qib7 13998 16 with with IN cord-005453-4057qib7 13998 17 viral viral JJ cord-005453-4057qib7 13998 18 reactivation reactivation NN cord-005453-4057qib7 13998 19 ( ( -LRB- cord-005453-4057qib7 13998 20 p=0.049 p=0.049 NNP cord-005453-4057qib7 13998 21 ) ) -RRB- cord-005453-4057qib7 13998 22 , , . cord-005453-4057qib7 13999 1 5SCD 5scd JJ cord-005453-4057qib7 13999 2 on on IN cord-005453-4057qib7 13999 3 day5 day5 NNP cord-005453-4057qib7 13999 4 was be VBD cord-005453-4057qib7 13999 5 associated associate VBN cord-005453-4057qib7 13999 6 with with IN cord-005453-4057qib7 13999 7 PES PES NNP cord-005453-4057qib7 13999 8 ( ( -LRB- cord-005453-4057qib7 13999 9 p=0.034 p=0.034 NNP cord-005453-4057qib7 13999 10 ) ) -RRB- cord-005453-4057qib7 13999 11 , , , cord-005453-4057qib7 13999 12 and and CC cord-005453-4057qib7 13999 13 5SCD 5scd JJ cord-005453-4057qib7 13999 14 on on IN cord-005453-4057qib7 13999 15 day40 day40 NNP cord-005453-4057qib7 13999 16 was be VBD cord-005453-4057qib7 13999 17 associated associate VBN cord-005453-4057qib7 13999 18 with with IN cord-005453-4057qib7 13999 19 malignant malignant JJ cord-005453-4057qib7 13999 20 disease disease NN cord-005453-4057qib7 13999 21 ( ( -LRB- cord-005453-4057qib7 13999 22 p=0.04 p=0.04 NN cord-005453-4057qib7 13999 23 ) ) -RRB- cord-005453-4057qib7 13999 24 . . . cord-005453-4057qib7 14000 1 Similarly similarly RB cord-005453-4057qib7 14000 2 , , , cord-005453-4057qib7 14000 3 in in IN cord-005453-4057qib7 14000 4 patient patient NN cord-005453-4057qib7 14000 5 who who WP cord-005453-4057qib7 14000 6 received receive VBD cord-005453-4057qib7 14000 7 allogeneic allogeneic IN cord-005453-4057qib7 14000 8 SCT SCT NNP cord-005453-4057qib7 14000 9 ( ( -LRB- cord-005453-4057qib7 14000 10 N=34 N=34 NNP cord-005453-4057qib7 14000 11 ) ) -RRB- cord-005453-4057qib7 14000 12 , , , cord-005453-4057qib7 14000 13 the the DT cord-005453-4057qib7 14000 14 level level NN cord-005453-4057qib7 14000 15 of of IN cord-005453-4057qib7 14000 16 5SCD 5scd NN cord-005453-4057qib7 14000 17 on on IN cord-005453-4057qib7 14000 18 day0 day0 NNS cord-005453-4057qib7 14000 19 was be VBD cord-005453-4057qib7 14000 20 associated associate VBN cord-005453-4057qib7 14000 21 with with IN cord-005453-4057qib7 14000 22 viral viral JJ cord-005453-4057qib7 14000 23 reactivation reactivation NN cord-005453-4057qib7 14000 24 ( ( -LRB- cord-005453-4057qib7 14000 25 p=0.048 p=0.048 NNP cord-005453-4057qib7 14000 26 ) ) -RRB- cord-005453-4057qib7 14000 27 , , , cord-005453-4057qib7 14000 28 5SCD 5scd JJ cord-005453-4057qib7 14000 29 on on IN cord-005453-4057qib7 14000 30 day5 day5 NN cord-005453-4057qib7 14000 31 was be VBD cord-005453-4057qib7 14000 32 was be VBD cord-005453-4057qib7 14000 33 associated associate VBN cord-005453-4057qib7 14000 34 with with IN cord-005453-4057qib7 14000 35 PES PES NNP cord-005453-4057qib7 14000 36 ( ( -LRB- cord-005453-4057qib7 14000 37 p=0.034 p=0.034 NNP cord-005453-4057qib7 14000 38 ) ) -RRB- cord-005453-4057qib7 14000 39 , , , cord-005453-4057qib7 14000 40 5SCD 5scd RB cord-005453-4057qib7 14000 41 on on IN cord-005453-4057qib7 14000 42 day day NN cord-005453-4057qib7 14000 43 40 40 CD cord-005453-4057qib7 14000 44 was be VBD cord-005453-4057qib7 14000 45 associated associate VBN cord-005453-4057qib7 14000 46 with with IN cord-005453-4057qib7 14000 47 malignant malignant JJ cord-005453-4057qib7 14000 48 disease disease NN cord-005453-4057qib7 14000 49 ( ( -LRB- cord-005453-4057qib7 14000 50 p=0.04 p=0.04 NN cord-005453-4057qib7 14000 51 ) ) -RRB- cord-005453-4057qib7 14000 52 . . . cord-005453-4057qib7 14001 1 In in IN cord-005453-4057qib7 14001 2 addition addition NN cord-005453-4057qib7 14001 3 , , , cord-005453-4057qib7 14001 4 the the DT cord-005453-4057qib7 14001 5 level level NN cord-005453-4057qib7 14001 6 of of IN cord-005453-4057qib7 14001 7 5SCD 5scd NN cord-005453-4057qib7 14001 8 on on IN cord-005453-4057qib7 14001 9 day5 day5 NN cord-005453-4057qib7 14001 10 was be VBD cord-005453-4057qib7 14001 11 associated associate VBN cord-005453-4057qib7 14001 12 with with IN cord-005453-4057qib7 14001 13 GVHD GVHD NNP cord-005453-4057qib7 14001 14 of of IN cord-005453-4057qib7 14001 15 skin skin NN cord-005453-4057qib7 14001 16 ( ( -LRB- cord-005453-4057qib7 14001 17 p=0.027 p=0.027 NNP cord-005453-4057qib7 14001 18 ) ) -RRB- cord-005453-4057qib7 14001 19 , , , cord-005453-4057qib7 14001 20 the the DT cord-005453-4057qib7 14001 21 peak peak NN cord-005453-4057qib7 14001 22 level level NN cord-005453-4057qib7 14001 23 of of IN cord-005453-4057qib7 14001 24 5SCD 5scd CD cord-005453-4057qib7 14001 25 was be VBD cord-005453-4057qib7 14001 26 associated associate VBN cord-005453-4057qib7 14001 27 with with IN cord-005453-4057qib7 14001 28 acute acute JJ cord-005453-4057qib7 14001 29 GVHD GVHD NNP cord-005453-4057qib7 14001 30 ( ( -LRB- cord-005453-4057qib7 14001 31 p=0.04 p=0.04 NNP cord-005453-4057qib7 14001 32 ) ) -RRB- cord-005453-4057qib7 14001 33 . . . cord-005453-4057qib7 14002 1 Conclusions conclusion NNS cord-005453-4057qib7 14002 2 : : : cord-005453-4057qib7 14003 1 We -PRON- PRP cord-005453-4057qib7 14003 2 found find VBD cord-005453-4057qib7 14003 3 that that IN cord-005453-4057qib7 14003 4 5SCD 5scd NN cord-005453-4057qib7 14003 5 can can MD cord-005453-4057qib7 14003 6 be be VB cord-005453-4057qib7 14003 7 a a DT cord-005453-4057qib7 14003 8 biomarker biomarker NN cord-005453-4057qib7 14003 9 for for IN cord-005453-4057qib7 14003 10 SCT SCT NNP cord-005453-4057qib7 14003 11 - - HYPH cord-005453-4057qib7 14003 12 related relate VBN cord-005453-4057qib7 14003 13 complications complication NNS cord-005453-4057qib7 14003 14 such such JJ cord-005453-4057qib7 14003 15 as as IN cord-005453-4057qib7 14003 16 aute aute NNP cord-005453-4057qib7 14003 17 GVHD GVHD NNP cord-005453-4057qib7 14003 18 . . . cord-005453-4057qib7 14004 1 It -PRON- PRP cord-005453-4057qib7 14004 2 is be VBZ cord-005453-4057qib7 14004 3 presumed presume VBN cord-005453-4057qib7 14004 4 that that IN cord-005453-4057qib7 14004 5 the the DT cord-005453-4057qib7 14004 6 production production NN cord-005453-4057qib7 14004 7 of of IN cord-005453-4057qib7 14004 8 pheomelanin pheomelanin NNS cord-005453-4057qib7 14004 9 could could MD cord-005453-4057qib7 14004 10 be be VB cord-005453-4057qib7 14004 11 induced induce VBN cord-005453-4057qib7 14004 12 by by IN cord-005453-4057qib7 14004 13 inflammatory inflammatory JJ cord-005453-4057qib7 14004 14 procedure procedure NN cord-005453-4057qib7 14004 15 in in IN cord-005453-4057qib7 14004 16 SCT SCT NNP cord-005453-4057qib7 14004 17 . . . cord-005453-4057qib7 14005 1 Disclosure disclosure NN cord-005453-4057qib7 14005 2 : : : cord-005453-4057qib7 14005 3 Nothing nothing NN cord-005453-4057qib7 14005 4 to to TO cord-005453-4057qib7 14005 5 declare declare VB cord-005453-4057qib7 14005 6 P644 p644 CD cord-005453-4057qib7 14005 7 HSCT HSCT NNP cord-005453-4057qib7 14005 8 in in IN cord-005453-4057qib7 14005 9 children child NNS cord-005453-4057qib7 14005 10 with with IN cord-005453-4057qib7 14005 11 bone bone NN cord-005453-4057qib7 14005 12 marrow marrow NN cord-005453-4057qib7 14005 13 failure failure NN cord-005453-4057qib7 14005 14 : : : cord-005453-4057qib7 14005 15 Outcomes outcome NNS cord-005453-4057qib7 14005 16 from from IN cord-005453-4057qib7 14005 17 a a DT cord-005453-4057qib7 14005 18 single single JJ cord-005453-4057qib7 14005 19 Singapore Singapore NNP cord-005453-4057qib7 14005 20 centre centre NN cord-005453-4057qib7 14005 21 Prasad Prasad NNP cord-005453-4057qib7 14005 22 Iyer Iyer NNP cord-005453-4057qib7 14005 23 1 1 CD cord-005453-4057qib7 14005 24 , , , cord-005453-4057qib7 14005 25 Michaela Michaela NNP cord-005453-4057qib7 14005 26 Seng Seng NNP cord-005453-4057qib7 14005 27 1 1 CD cord-005453-4057qib7 14005 28 , , , cord-005453-4057qib7 14005 29 Vijayakumari Vijayakumari NNP cord-005453-4057qib7 14005 30 K K NNP cord-005453-4057qib7 14005 31 1 1 CD cord-005453-4057qib7 14005 32 , , , cord-005453-4057qib7 14005 33 Ah Ah NNP cord-005453-4057qib7 14005 34 Moy Moy NNP cord-005453-4057qib7 14005 35 Tan Tan NNP cord-005453-4057qib7 14005 36 1 1 CD cord-005453-4057qib7 14005 37 , , , cord-005453-4057qib7 14005 38 Mei Mei NNP cord-005453-4057qib7 14005 39 Yoke Yoke NNP cord-005453-4057qib7 14005 40 Chan Chan NNP cord-005453-4057qib7 14005 41 1 1 CD cord-005453-4057qib7 14005 42 , , , cord-005453-4057qib7 14005 43 Rajat Rajat NNP cord-005453-4057qib7 14005 44 Bhattacharyya Bhattacharyya NNP cord-005453-4057qib7 14006 1 1 1 CD cord-005453-4057qib7 14006 2 1 1 CD cord-005453-4057qib7 14006 3 KK KK NNP cord-005453-4057qib7 14006 4 Women Women NNP cord-005453-4057qib7 14006 5 's 's POS cord-005453-4057qib7 14006 6 and and CC cord-005453-4057qib7 14007 1 Children child NNS cord-005453-4057qib7 14007 2 's 's POS cord-005453-4057qib7 14007 3 Hospital Hospital NNP cord-005453-4057qib7 14007 4 , , , cord-005453-4057qib7 14007 5 Paediatric Paediatric NNP cord-005453-4057qib7 14007 6 Haematology Haematology NNP cord-005453-4057qib7 14007 7 - - HYPH cord-005453-4057qib7 14007 8 Oncology Oncology NNP cord-005453-4057qib7 14007 9 , , , cord-005453-4057qib7 14007 10 Singapore Singapore NNP cord-005453-4057qib7 14007 11 , , , cord-005453-4057qib7 14007 12 Singapore Singapore NNP cord-005453-4057qib7 14007 13 Background Background NNP cord-005453-4057qib7 14007 14 : : : cord-005453-4057qib7 14008 1 Children child NNS cord-005453-4057qib7 14008 2 presenting present VBG cord-005453-4057qib7 14008 3 with with IN cord-005453-4057qib7 14008 4 pancytopenia pancytopenia NNP cord-005453-4057qib7 14008 5 often often RB cord-005453-4057qib7 14008 6 present present VBP cord-005453-4057qib7 14008 7 a a DT cord-005453-4057qib7 14008 8 challenge challenge NN cord-005453-4057qib7 14008 9 to to IN cord-005453-4057qib7 14008 10 the the DT cord-005453-4057qib7 14008 11 paediatric paediatric JJ cord-005453-4057qib7 14008 12 haematologist haematologist NN cord-005453-4057qib7 14008 13 . . . cord-005453-4057qib7 14009 1 The the DT cord-005453-4057qib7 14009 2 underlying underlie VBG cord-005453-4057qib7 14009 3 diagnosis diagnosis NN cord-005453-4057qib7 14009 4 can can MD cord-005453-4057qib7 14009 5 be be VB cord-005453-4057qib7 14009 6 hard hard JJ cord-005453-4057qib7 14009 7 to to TO cord-005453-4057qib7 14009 8 establish establish VB cord-005453-4057qib7 14009 9 as as RB cord-005453-4057qib7 14009 10 many many JJ cord-005453-4057qib7 14009 11 of of IN cord-005453-4057qib7 14009 12 the the DT cord-005453-4057qib7 14009 13 inherited inherit VBN cord-005453-4057qib7 14009 14 bone bone NN cord-005453-4057qib7 14009 15 marrow marrow NN cord-005453-4057qib7 14009 16 failure failure NN cord-005453-4057qib7 14009 17 syndromes syndrome NNS cord-005453-4057qib7 14009 18 ( ( -LRB- cord-005453-4057qib7 14009 19 IBMFS IBMFS NNP cord-005453-4057qib7 14009 20 ) ) -RRB- cord-005453-4057qib7 14009 21 can can MD cord-005453-4057qib7 14009 22 present present VB cord-005453-4057qib7 14009 23 with with IN cord-005453-4057qib7 14009 24 protean protean JJ cord-005453-4057qib7 14009 25 manifestations manifestation NNS cord-005453-4057qib7 14009 26 . . . cord-005453-4057qib7 14010 1 The the DT cord-005453-4057qib7 14010 2 large large JJ cord-005453-4057qib7 14010 3 majority majority NN cord-005453-4057qib7 14010 4 of of IN cord-005453-4057qib7 14010 5 patients patient NNS cord-005453-4057qib7 14010 6 with with IN cord-005453-4057qib7 14010 7 bone bone NN cord-005453-4057qib7 14010 8 marrow marrow NN cord-005453-4057qib7 14010 9 failure failure NN cord-005453-4057qib7 14010 10 are be VBP cord-005453-4057qib7 14010 11 often often RB cord-005453-4057qib7 14010 12 diagnosed diagnose VBN cord-005453-4057qib7 14010 13 with with IN cord-005453-4057qib7 14010 14 idiopathic idiopathic JJ cord-005453-4057qib7 14010 15 severe severe JJ cord-005453-4057qib7 14010 16 aplastic aplastic JJ cord-005453-4057qib7 14010 17 anaemia anaemia NN cord-005453-4057qib7 14010 18 ( ( -LRB- cord-005453-4057qib7 14010 19 SAA SAA NNP cord-005453-4057qib7 14010 20 ) ) -RRB- cord-005453-4057qib7 14010 21 despite despite IN cord-005453-4057qib7 14010 22 extensive extensive JJ cord-005453-4057qib7 14010 23 testing testing NN cord-005453-4057qib7 14010 24 . . . cord-005453-4057qib7 14011 1 We -PRON- PRP cord-005453-4057qib7 14011 2 report report VBP cord-005453-4057qib7 14011 3 our -PRON- PRP$ cord-005453-4057qib7 14011 4 experience experience NN cord-005453-4057qib7 14011 5 of of IN cord-005453-4057qib7 14011 6 HSCT HSCT NNP cord-005453-4057qib7 14011 7 in in IN cord-005453-4057qib7 14011 8 patients patient NNS cord-005453-4057qib7 14011 9 treated treat VBN cord-005453-4057qib7 14011 10 with with IN cord-005453-4057qib7 14011 11 primary primary JJ cord-005453-4057qib7 14011 12 and and CC cord-005453-4057qib7 14011 13 acquired acquire VBN cord-005453-4057qib7 14011 14 bone bone NN cord-005453-4057qib7 14011 15 marrow marrow NN cord-005453-4057qib7 14011 16 failure failure NN cord-005453-4057qib7 14011 17 . . . cord-005453-4057qib7 14012 1 Methods method NNS cord-005453-4057qib7 14012 2 : : : cord-005453-4057qib7 14012 3 We -PRON- PRP cord-005453-4057qib7 14012 4 reviewed review VBD cord-005453-4057qib7 14012 5 case case NN cord-005453-4057qib7 14012 6 notes note NNS cord-005453-4057qib7 14012 7 of of IN cord-005453-4057qib7 14012 8 all all PDT cord-005453-4057qib7 14012 9 the the DT cord-005453-4057qib7 14012 10 children child NNS cord-005453-4057qib7 14012 11 who who WP cord-005453-4057qib7 14012 12 underwent undergo VBD cord-005453-4057qib7 14012 13 HSCT HSCT NNP cord-005453-4057qib7 14012 14 for for IN cord-005453-4057qib7 14012 15 bone bone NN cord-005453-4057qib7 14012 16 marrow marrow NN cord-005453-4057qib7 14012 17 failure failure NN cord-005453-4057qib7 14012 18 in in IN cord-005453-4057qib7 14012 19 our -PRON- PRP$ cord-005453-4057qib7 14012 20 centre centre NN cord-005453-4057qib7 14012 21 . . . cord-005453-4057qib7 14013 1 Results result NNS cord-005453-4057qib7 14013 2 : : : cord-005453-4057qib7 14014 1 A a DT cord-005453-4057qib7 14014 2 total total NN cord-005453-4057qib7 14014 3 of of IN cord-005453-4057qib7 14014 4 fifteen fifteen CD cord-005453-4057qib7 14014 5 patients patient NNS cord-005453-4057qib7 14014 6 underwent undergo VBD cord-005453-4057qib7 14014 7 eighteen eighteen CD cord-005453-4057qib7 14014 8 stem stem NN cord-005453-4057qib7 14014 9 cell cell NN cord-005453-4057qib7 14014 10 transplants transplant NNS cord-005453-4057qib7 14014 11 in in IN cord-005453-4057qib7 14014 12 our -PRON- PRP$ cord-005453-4057qib7 14014 13 centre centre NN cord-005453-4057qib7 14014 14 between between IN cord-005453-4057qib7 14014 15 2003 2003 CD cord-005453-4057qib7 14014 16 and and CC cord-005453-4057qib7 14014 17 2016 2016 CD cord-005453-4057qib7 14014 18 . . . cord-005453-4057qib7 14015 1 Three three CD cord-005453-4057qib7 14015 2 patients patient NNS cord-005453-4057qib7 14015 3 were be VBD cord-005453-4057qib7 14015 4 diagnosed diagnose VBN cord-005453-4057qib7 14015 5 with with IN cord-005453-4057qib7 14015 6 Fanconi Fanconi NNP cord-005453-4057qib7 14015 7 Anaemia Anaemia NNP cord-005453-4057qib7 14015 8 , , , cord-005453-4057qib7 14015 9 one one CD cord-005453-4057qib7 14015 10 with with IN cord-005453-4057qib7 14015 11 Hoyeraal Hoyeraal NNP cord-005453-4057qib7 14015 12 - - HYPH cord-005453-4057qib7 14015 13 Hreidarsson Hreidarsson NNP cord-005453-4057qib7 14015 14 syndrome syndrome NN cord-005453-4057qib7 14015 15 , , , cord-005453-4057qib7 14015 16 one one CD cord-005453-4057qib7 14015 17 with with IN cord-005453-4057qib7 14015 18 paroxysmal paroxysmal JJ cord-005453-4057qib7 14015 19 nocturnal nocturnal JJ cord-005453-4057qib7 14015 20 haemoglobinuria haemoglobinuria NNS cord-005453-4057qib7 14015 21 and and CC cord-005453-4057qib7 14015 22 the the DT cord-005453-4057qib7 14015 23 remaining remain VBG cord-005453-4057qib7 14015 24 ten ten CD cord-005453-4057qib7 14015 25 children child NNS cord-005453-4057qib7 14015 26 had have VBD cord-005453-4057qib7 14015 27 idiopathic idiopathic JJ cord-005453-4057qib7 14015 28 SAA SAA NNP cord-005453-4057qib7 14015 29 . . . cord-005453-4057qib7 14016 1 Eight eight CD cord-005453-4057qib7 14016 2 children child NNS cord-005453-4057qib7 14016 3 had have VBD cord-005453-4057qib7 14016 4 matched match VBN cord-005453-4057qib7 14016 5 sibling sibling NN cord-005453-4057qib7 14016 6 donor donor NN cord-005453-4057qib7 14016 7 transplant transplant NN cord-005453-4057qib7 14016 8 , , , cord-005453-4057qib7 14016 9 1 1 CD cord-005453-4057qib7 14016 10 had have VBD cord-005453-4057qib7 14016 11 a a DT cord-005453-4057qib7 14016 12 matched match VBN cord-005453-4057qib7 14016 13 related related JJ cord-005453-4057qib7 14016 14 donor donor NN cord-005453-4057qib7 14016 15 , , , cord-005453-4057qib7 14016 16 1 1 CD cord-005453-4057qib7 14016 17 had have VBD cord-005453-4057qib7 14016 18 a a DT cord-005453-4057qib7 14016 19 matched match VBN cord-005453-4057qib7 14016 20 unrelated unrelated JJ cord-005453-4057qib7 14016 21 donor donor NN cord-005453-4057qib7 14016 22 , , , cord-005453-4057qib7 14016 23 3 3 CD cord-005453-4057qib7 14016 24 had have VBD cord-005453-4057qib7 14016 25 umbilical umbilical JJ cord-005453-4057qib7 14016 26 cord cord NN cord-005453-4057qib7 14016 27 blood blood NN cord-005453-4057qib7 14016 28 transplants transplant NNS cord-005453-4057qib7 14016 29 and and CC cord-005453-4057qib7 14016 30 the the DT cord-005453-4057qib7 14016 31 remainder remainder NN cord-005453-4057qib7 14016 32 5 5 CD cord-005453-4057qib7 14016 33 were be VBD cord-005453-4057qib7 14016 34 haploidentical haploidentical JJ cord-005453-4057qib7 14016 35 transplants transplant NNS cord-005453-4057qib7 14016 36 . . . cord-005453-4057qib7 14017 1 Four four CD cord-005453-4057qib7 14017 2 of of IN cord-005453-4057qib7 14017 3 the the DT cord-005453-4057qib7 14017 4 haploidentical haploidentical JJ cord-005453-4057qib7 14017 5 transplants transplant NNS cord-005453-4057qib7 14017 6 were be VBD cord-005453-4057qib7 14017 7 T t NN cord-005453-4057qib7 14017 8 - - HYPH cord-005453-4057qib7 14017 9 cell cell NN cord-005453-4057qib7 14017 10 depleted deplete VBN cord-005453-4057qib7 14017 11 and and CC cord-005453-4057qib7 14017 12 one one CD cord-005453-4057qib7 14017 13 was be VBD cord-005453-4057qib7 14017 14 T t NN cord-005453-4057qib7 14017 15 - - HYPH cord-005453-4057qib7 14017 16 cell cell NN cord-005453-4057qib7 14017 17 replete replete NN cord-005453-4057qib7 14017 18 . . . cord-005453-4057qib7 14018 1 One one CD cord-005453-4057qib7 14018 2 child child NN cord-005453-4057qib7 14018 3 with with IN cord-005453-4057qib7 14018 4 Fanconi Fanconi NNP cord-005453-4057qib7 14018 5 anaemia anaemia NN cord-005453-4057qib7 14018 6 had have VBD cord-005453-4057qib7 14018 7 primary primary JJ cord-005453-4057qib7 14018 8 graft graft NN cord-005453-4057qib7 14018 9 rejection rejection NN cord-005453-4057qib7 14018 10 with with IN cord-005453-4057qib7 14018 11 cord cord NN cord-005453-4057qib7 14018 12 blood blood NN cord-005453-4057qib7 14018 13 transplant transplant NN cord-005453-4057qib7 14018 14 and and CC cord-005453-4057qib7 14018 15 was be VBD cord-005453-4057qib7 14018 16 successfully successfully RB cord-005453-4057qib7 14018 17 rescued rescue VBN cord-005453-4057qib7 14018 18 with with IN cord-005453-4057qib7 14018 19 a a DT cord-005453-4057qib7 14018 20 haploidentical haploidentical JJ cord-005453-4057qib7 14018 21 transplant transplant NN cord-005453-4057qib7 14018 22 . . . cord-005453-4057qib7 14019 1 One one CD cord-005453-4057qib7 14019 2 child child NN cord-005453-4057qib7 14019 3 with with IN cord-005453-4057qib7 14019 4 SAA SAA NNP cord-005453-4057qib7 14019 5 had have VBD cord-005453-4057qib7 14019 6 primary primary JJ cord-005453-4057qib7 14019 7 graft graft NN cord-005453-4057qib7 14019 8 rejection rejection NN cord-005453-4057qib7 14019 9 twice twice RB cord-005453-4057qib7 14019 10 ( ( -LRB- cord-005453-4057qib7 14019 11 T t NN cord-005453-4057qib7 14019 12 - - HYPH cord-005453-4057qib7 14019 13 cell cell NN cord-005453-4057qib7 14019 14 depleted deplete VBN cord-005453-4057qib7 14019 15 graft graft NN cord-005453-4057qib7 14019 16 ) ) -RRB- cord-005453-4057qib7 14019 17 and and CC cord-005453-4057qib7 14019 18 then then RB cord-005453-4057qib7 14019 19 was be VBD cord-005453-4057qib7 14019 20 rescued rescue VBN cord-005453-4057qib7 14019 21 with with IN cord-005453-4057qib7 14019 22 an an DT cord-005453-4057qib7 14019 23 alternate alternate JJ cord-005453-4057qib7 14019 24 haploidentical haploidentical JJ cord-005453-4057qib7 14019 25 donor donor NN cord-005453-4057qib7 14019 26 with with IN cord-005453-4057qib7 14019 27 a a DT cord-005453-4057qib7 14019 28 T t NN cord-005453-4057qib7 14019 29 - - HYPH cord-005453-4057qib7 14019 30 cell cell NN cord-005453-4057qib7 14019 31 replete replete JJ cord-005453-4057qib7 14019 32 graft graft NN cord-005453-4057qib7 14019 33 . . . cord-005453-4057qib7 14020 1 Of of IN cord-005453-4057qib7 14020 2 the the DT cord-005453-4057qib7 14020 3 two two CD cord-005453-4057qib7 14020 4 patients patient NNS cord-005453-4057qib7 14020 5 who who WP cord-005453-4057qib7 14020 6 died die VBD cord-005453-4057qib7 14020 7 , , , cord-005453-4057qib7 14020 8 one one PRP cord-005453-4057qib7 14020 9 had have VBD cord-005453-4057qib7 14020 10 a a DT cord-005453-4057qib7 14020 11 fatal fatal JJ cord-005453-4057qib7 14020 12 fungal fungal NN cord-005453-4057qib7 14020 13 infection infection NN cord-005453-4057qib7 14020 14 ten ten CD cord-005453-4057qib7 14020 15 months month NNS cord-005453-4057qib7 14020 16 after after IN cord-005453-4057qib7 14020 17 transplant transplant NN cord-005453-4057qib7 14020 18 , , , cord-005453-4057qib7 14020 19 and and CC cord-005453-4057qib7 14020 20 the the DT cord-005453-4057qib7 14020 21 other other JJ cord-005453-4057qib7 14020 22 died die VBD cord-005453-4057qib7 14020 23 due due IN cord-005453-4057qib7 14020 24 to to IN cord-005453-4057qib7 14020 25 a a DT cord-005453-4057qib7 14020 26 severe severe JJ cord-005453-4057qib7 14020 27 influenza influenza NN cord-005453-4057qib7 14020 28 pneumonitis pneumonitis NN cord-005453-4057qib7 14020 29 three three CD cord-005453-4057qib7 14020 30 and and CC cord-005453-4057qib7 14020 31 a a DT cord-005453-4057qib7 14020 32 half half NN cord-005453-4057qib7 14020 33 years year NNS cord-005453-4057qib7 14020 34 after after IN cord-005453-4057qib7 14020 35 BMT BMT NNP cord-005453-4057qib7 14020 36 . . . cord-005453-4057qib7 14021 1 Conclusions conclusion NNS cord-005453-4057qib7 14021 2 : : : cord-005453-4057qib7 14022 1 Haematopoietic haematopoietic JJ cord-005453-4057qib7 14022 2 stem stem NN cord-005453-4057qib7 14022 3 cell cell NN cord-005453-4057qib7 14022 4 transplant transplant NN cord-005453-4057qib7 14022 5 outcomes outcome NNS cord-005453-4057qib7 14022 6 from from IN cord-005453-4057qib7 14022 7 our -PRON- PRP$ cord-005453-4057qib7 14022 8 centre centre NN cord-005453-4057qib7 14022 9 are be VBP cord-005453-4057qib7 14022 10 comparable comparable JJ cord-005453-4057qib7 14022 11 to to IN cord-005453-4057qib7 14022 12 leading lead VBG cord-005453-4057qib7 14022 13 centres centre NNS cord-005453-4057qib7 14022 14 in in IN cord-005453-4057qib7 14022 15 the the DT cord-005453-4057qib7 14022 16 world world NN cord-005453-4057qib7 14022 17 . . . cord-005453-4057qib7 14023 1 The the DT cord-005453-4057qib7 14023 2 understanding understanding NN cord-005453-4057qib7 14023 3 of of IN cord-005453-4057qib7 14023 4 underlying underlying JJ cord-005453-4057qib7 14023 5 conditions condition NNS cord-005453-4057qib7 14023 6 that that WDT cord-005453-4057qib7 14023 7 present present VBP cord-005453-4057qib7 14023 8 with with IN cord-005453-4057qib7 14023 9 bone bone NN cord-005453-4057qib7 14023 10 marrow marrow NN cord-005453-4057qib7 14023 11 failure failure NN cord-005453-4057qib7 14023 12 has have VBZ cord-005453-4057qib7 14023 13 improved improve VBN cord-005453-4057qib7 14023 14 our -PRON- PRP$ cord-005453-4057qib7 14023 15 approach approach NN cord-005453-4057qib7 14023 16 and and CC cord-005453-4057qib7 14023 17 the the DT cord-005453-4057qib7 14023 18 way way NN cord-005453-4057qib7 14023 19 we -PRON- PRP cord-005453-4057qib7 14023 20 treat treat VBP cord-005453-4057qib7 14023 21 bone bone NN cord-005453-4057qib7 14023 22 marrow marrow NN cord-005453-4057qib7 14023 23 failure failure NN cord-005453-4057qib7 14023 24 syndromes syndrome NNS cord-005453-4057qib7 14023 25 . . . cord-005453-4057qib7 14024 1 Clinical clinical JJ cord-005453-4057qib7 14024 2 Trial Trial NNP cord-005453-4057qib7 14024 3 Registry Registry NNP cord-005453-4057qib7 14024 4 : : : cord-005453-4057qib7 14025 1 Not not RB cord-005453-4057qib7 14025 2 applicable applicable JJ cord-005453-4057qib7 14025 3 . . . cord-005453-4057qib7 14026 1 Disclosure disclosure NN cord-005453-4057qib7 14026 2 : : : cord-005453-4057qib7 14026 3 Nothing nothing NN cord-005453-4057qib7 14026 4 to to TO cord-005453-4057qib7 14026 5 declare declare VB cord-005453-4057qib7 14026 6 . . . cord-005453-4057qib7 14027 1 Methods method NNS cord-005453-4057qib7 14027 2 : : : cord-005453-4057qib7 14028 1 A a DT cord-005453-4057qib7 14028 2 retrospective retrospective JJ cord-005453-4057qib7 14028 3 study study NN cord-005453-4057qib7 14028 4 was be VBD cord-005453-4057qib7 14028 5 performed perform VBN cord-005453-4057qib7 14028 6 in in IN cord-005453-4057qib7 14028 7 children child NNS cord-005453-4057qib7 14028 8 treated treat VBN cord-005453-4057qib7 14028 9 with with IN cord-005453-4057qib7 14028 10 HSCT HSCT NNP cord-005453-4057qib7 14028 11 who who WP cord-005453-4057qib7 14028 12 received receive VBD cord-005453-4057qib7 14028 13 POS POS NNP cord-005453-4057qib7 14028 14 or or CC cord-005453-4057qib7 14028 15 FLU FLU NNP cord-005453-4057qib7 14028 16 during during IN cord-005453-4057qib7 14028 17 early early JJ cord-005453-4057qib7 14028 18 neutropenic neutropenic JJ cord-005453-4057qib7 14028 19 period period NN cord-005453-4057qib7 14028 20 until until IN cord-005453-4057qib7 14028 21 engraftment engraftment NN cord-005453-4057qib7 14028 22 from from IN cord-005453-4057qib7 14028 23 January January NNP cord-005453-4057qib7 14028 24 2000 2000 CD cord-005453-4057qib7 14028 25 to to IN cord-005453-4057qib7 14028 26 December December NNP cord-005453-4057qib7 14028 27 2017 2017 CD cord-005453-4057qib7 14028 28 at at IN cord-005453-4057qib7 14028 29 Siriraj Siriraj NNP cord-005453-4057qib7 14028 30 hospital hospital NN cord-005453-4057qib7 14028 31 in in IN cord-005453-4057qib7 14028 32 Thailand Thailand NNP cord-005453-4057qib7 14028 33 . . . cord-005453-4057qib7 14029 1 The the DT cord-005453-4057qib7 14029 2 efficacy efficacy NN cord-005453-4057qib7 14029 3 , , , cord-005453-4057qib7 14029 4 safety safety NN cord-005453-4057qib7 14029 5 and and CC cord-005453-4057qib7 14029 6 tolerability tolerability NN cord-005453-4057qib7 14029 7 of of IN cord-005453-4057qib7 14029 8 POS POS NNP cord-005453-4057qib7 14029 9 were be VBD cord-005453-4057qib7 14029 10 compared compare VBN cord-005453-4057qib7 14029 11 to to IN cord-005453-4057qib7 14029 12 FLU flu NN cord-005453-4057qib7 14029 13 . . . cord-005453-4057qib7 14030 1 Results result NNS cord-005453-4057qib7 14030 2 : : : cord-005453-4057qib7 14031 1 There there EX cord-005453-4057qib7 14031 2 were be VBD cord-005453-4057qib7 14031 3 66 66 CD cord-005453-4057qib7 14031 4 HSCT HSCT NNP cord-005453-4057qib7 14031 5 recipients recipient NNS cord-005453-4057qib7 14031 6 ( ( -LRB- cord-005453-4057qib7 14031 7 allo allo NN cord-005453-4057qib7 14031 8 - - HYPH cord-005453-4057qib7 14031 9 HSCT HSCT NNP cord-005453-4057qib7 14031 10 62.1 62.1 CD cord-005453-4057qib7 14031 11 % % NN cord-005453-4057qib7 14031 12 , , , cord-005453-4057qib7 14031 13 auto auto NN cord-005453-4057qib7 14031 14 - - HYPH cord-005453-4057qib7 14031 15 HSCT HSCT NNP cord-005453-4057qib7 14031 16 37.9 37.9 CD cord-005453-4057qib7 14031 17 % % NN cord-005453-4057qib7 14031 18 ) ) -RRB- cord-005453-4057qib7 14031 19 with with IN cord-005453-4057qib7 14031 20 mean mean JJ cord-005453-4057qib7 14031 21 age age NN cord-005453-4057qib7 14031 22 of of IN cord-005453-4057qib7 14031 23 7.6 7.6 CD cord-005453-4057qib7 14031 24 + + SYM cord-005453-4057qib7 14031 25 4.3 4.3 CD cord-005453-4057qib7 14031 26 years year NNS cord-005453-4057qib7 14031 27 . . . cord-005453-4057qib7 14032 1 Most Most JJS cord-005453-4057qib7 14032 2 of of IN cord-005453-4057qib7 14032 3 the the DT cord-005453-4057qib7 14032 4 patients patient NNS cord-005453-4057qib7 14032 5 were be VBD cord-005453-4057qib7 14032 6 thalassemia thalassemia NN cord-005453-4057qib7 14032 7 ( ( -LRB- cord-005453-4057qib7 14032 8 34.4 34.4 CD cord-005453-4057qib7 14032 9 % % NN cord-005453-4057qib7 14032 10 ) ) -RRB- cord-005453-4057qib7 14032 11 followed follow VBN cord-005453-4057qib7 14032 12 by by IN cord-005453-4057qib7 14032 13 hematologic hematologic JJ cord-005453-4057qib7 14032 14 malignancy malignancy NN cord-005453-4057qib7 14032 15 ( ( -LRB- cord-005453-4057qib7 14032 16 32.2 32.2 CD cord-005453-4057qib7 14032 17 % % NN cord-005453-4057qib7 14032 18 ) ) -RRB- cord-005453-4057qib7 14032 19 and and CC cord-005453-4057qib7 14032 20 solid solid JJ cord-005453-4057qib7 14032 21 tumor tumor NN cord-005453-4057qib7 14032 22 ( ( -LRB- cord-005453-4057qib7 14032 23 16.7 16.7 CD cord-005453-4057qib7 14032 24 % % NN cord-005453-4057qib7 14032 25 ) ) -RRB- cord-005453-4057qib7 14032 26 . . . cord-005453-4057qib7 14033 1 Seventeen seventeen CD cord-005453-4057qib7 14033 2 and and CC cord-005453-4057qib7 14033 3 49 49 CD cord-005453-4057qib7 14033 4 cases case NNS cord-005453-4057qib7 14033 5 received receive VBD cord-005453-4057qib7 14033 6 POS POS NNP cord-005453-4057qib7 14033 7 and and CC cord-005453-4057qib7 14033 8 FLU FLU NNP cord-005453-4057qib7 14033 9 , , , cord-005453-4057qib7 14033 10 respectively respectively RB cord-005453-4057qib7 14033 11 . . . cord-005453-4057qib7 14034 1 All all DT cord-005453-4057qib7 14034 2 of of IN cord-005453-4057qib7 14034 3 patients patient NNS cord-005453-4057qib7 14034 4 in in IN cord-005453-4057qib7 14034 5 POS POS NNP cord-005453-4057qib7 14034 6 group group NN cord-005453-4057qib7 14034 7 were be VBD cord-005453-4057qib7 14034 8 allo allo NN cord-005453-4057qib7 14034 9 - - HYPH cord-005453-4057qib7 14034 10 HSCT HSCT NNP cord-005453-4057qib7 14034 11 whereas whereas IN cord-005453-4057qib7 14034 12 48.9 48.9 CD cord-005453-4057qib7 14034 13 % % NN cord-005453-4057qib7 14034 14 in in IN cord-005453-4057qib7 14034 15 FLU FLU NNP cord-005453-4057qib7 14034 16 group group NN cord-005453-4057qib7 14034 17 were be VBD cord-005453-4057qib7 14034 18 allo allo NN cord-005453-4057qib7 14034 19 - - HYPH cord-005453-4057qib7 14034 20 HSCT HSCT NNP cord-005453-4057qib7 14034 21 . . . cord-005453-4057qib7 14035 1 In in IN cord-005453-4057qib7 14035 2 POS POS NNP cord-005453-4057qib7 14035 3 group group NN cord-005453-4057qib7 14035 4 , , , cord-005453-4057qib7 14035 5 2 2 CD cord-005453-4057qib7 14035 6 cases case NNS cord-005453-4057qib7 14035 7 were be VBD cord-005453-4057qib7 14035 8 diagnosed diagnose VBN cord-005453-4057qib7 14035 9 with with IN cord-005453-4057qib7 14035 10 suspected suspect VBN cord-005453-4057qib7 14035 11 IFI IFI NNP cord-005453-4057qib7 14035 12 and and CC cord-005453-4057qib7 14035 13 2 2 CD cord-005453-4057qib7 14035 14 cases case NNS cord-005453-4057qib7 14035 15 were be VBD cord-005453-4057qib7 14035 16 probable probable JJ cord-005453-4057qib7 14035 17 IFI IFI NNP cord-005453-4057qib7 14035 18 with with IN cord-005453-4057qib7 14035 19 total total JJ cord-005453-4057qib7 14035 20 4 4 CD cord-005453-4057qib7 14035 21 cases case NNS cord-005453-4057qib7 14035 22 ( ( -LRB- cord-005453-4057qib7 14035 23 23.5 23.5 CD cord-005453-4057qib7 14035 24 % % NN cord-005453-4057qib7 14035 25 ) ) -RRB- cord-005453-4057qib7 14035 26 . . . cord-005453-4057qib7 14036 1 In in IN cord-005453-4057qib7 14036 2 FLU FLU NNP cord-005453-4057qib7 14036 3 group group NN cord-005453-4057qib7 14036 4 , , , cord-005453-4057qib7 14036 5 10 10 CD cord-005453-4057qib7 14036 6 cases case NNS cord-005453-4057qib7 14036 7 were be VBD cord-005453-4057qib7 14036 8 diagnosed diagnose VBN cord-005453-4057qib7 14036 9 with with IN cord-005453-4057qib7 14036 10 suspected suspect VBN cord-005453-4057qib7 14036 11 IFI IFI NNP cord-005453-4057qib7 14036 12 and and CC cord-005453-4057qib7 14036 13 2 2 CD cord-005453-4057qib7 14036 14 cases case NNS cord-005453-4057qib7 14036 15 were be VBD cord-005453-4057qib7 14036 16 probable probable JJ cord-005453-4057qib7 14036 17 IFI IFI NNP cord-005453-4057qib7 14036 18 with with IN cord-005453-4057qib7 14036 19 total total JJ cord-005453-4057qib7 14036 20 12 12 CD cord-005453-4057qib7 14036 21 cases case NNS cord-005453-4057qib7 14036 22 ( ( -LRB- cord-005453-4057qib7 14036 23 24.5 24.5 CD cord-005453-4057qib7 14036 24 % % NN cord-005453-4057qib7 14036 25 ) ) -RRB- cord-005453-4057qib7 14036 26 which which WDT cord-005453-4057qib7 14036 27 compared compare VBD cord-005453-4057qib7 14036 28 2 2 CD cord-005453-4057qib7 14036 29 groups group NNS cord-005453-4057qib7 14036 30 were be VBD cord-005453-4057qib7 14036 31 not not RB cord-005453-4057qib7 14036 32 statistically statistically RB cord-005453-4057qib7 14036 33 significant significant JJ cord-005453-4057qib7 14036 34 ( ( -LRB- cord-005453-4057qib7 14036 35 p=0.937 p=0.937 NN cord-005453-4057qib7 14036 36 ) ) -RRB- cord-005453-4057qib7 14036 37 . . . cord-005453-4057qib7 14037 1 No no DT cord-005453-4057qib7 14037 2 possible possible JJ cord-005453-4057qib7 14037 3 and and CC cord-005453-4057qib7 14037 4 proven prove VBN cord-005453-4057qib7 14037 5 IFI IFI NNP cord-005453-4057qib7 14037 6 in in IN cord-005453-4057qib7 14037 7 both both DT cord-005453-4057qib7 14037 8 groups group NNS cord-005453-4057qib7 14037 9 . . . cord-005453-4057qib7 14038 1 In in IN cord-005453-4057qib7 14038 2 FLU flu NN cord-005453-4057qib7 14038 3 group group NN cord-005453-4057qib7 14038 4 patients patient NNS cord-005453-4057qib7 14038 5 received receive VBD cord-005453-4057qib7 14038 6 empirical empirical JJ cord-005453-4057qib7 14038 7 antifungal antifungal JJ cord-005453-4057qib7 14038 8 treatment treatment NN cord-005453-4057qib7 14038 9 more more JJR cord-005453-4057qib7 14038 10 than than IN cord-005453-4057qib7 14038 11 POS POS NNP cord-005453-4057qib7 14038 12 group group NN cord-005453-4057qib7 14038 13 but but CC cord-005453-4057qib7 14038 14 no no DT cord-005453-4057qib7 14038 15 statistical statistical JJ cord-005453-4057qib7 14038 16 significance significance NN cord-005453-4057qib7 14038 17 ( ( -LRB- cord-005453-4057qib7 14038 18 20.4 20.4 CD cord-005453-4057qib7 14038 19 % % NN cord-005453-4057qib7 14038 20 VS.11.76 VS.11.76 NNP cord-005453-4057qib7 14038 21 % % NN cord-005453-4057qib7 14038 22 , , , cord-005453-4057qib7 14038 23 p=0.498 p=0.498 NNP cord-005453-4057qib7 14038 24 ) ) -RRB- cord-005453-4057qib7 14038 25 . . . cord-005453-4057qib7 14039 1 Both both DT cord-005453-4057qib7 14039 2 groups group NNS cord-005453-4057qib7 14039 3 had have VBD cord-005453-4057qib7 14039 4 similar similar JJ cord-005453-4057qib7 14039 5 rate rate NN cord-005453-4057qib7 14039 6 of of IN cord-005453-4057qib7 14039 7 elevated elevated JJ cord-005453-4057qib7 14039 8 liver liver NN cord-005453-4057qib7 14039 9 function function NN cord-005453-4057qib7 14039 10 test test NN cord-005453-4057qib7 14039 11 ( ( -LRB- cord-005453-4057qib7 14039 12 p=0.567 p=0.567 NNP cord-005453-4057qib7 14039 13 ) ) -RRB- cord-005453-4057qib7 14039 14 . . . cord-005453-4057qib7 14040 1 No no DT cord-005453-4057qib7 14040 2 early early JJ cord-005453-4057qib7 14040 3 discontinuation discontinuation NN cord-005453-4057qib7 14040 4 of of IN cord-005453-4057qib7 14040 5 antifungal antifungal JJ cord-005453-4057qib7 14040 6 prophylaxis prophylaxis NN cord-005453-4057qib7 14040 7 for for IN cord-005453-4057qib7 14040 8 intolerance intolerance NN cord-005453-4057qib7 14040 9 was be VBD cord-005453-4057qib7 14040 10 found find VBN cord-005453-4057qib7 14040 11 in in IN cord-005453-4057qib7 14040 12 both both DT cord-005453-4057qib7 14040 13 groups group NNS cord-005453-4057qib7 14040 14 . . . cord-005453-4057qib7 14041 1 Only only RB cord-005453-4057qib7 14041 2 26.7 26.7 CD cord-005453-4057qib7 14041 3 % % NN cord-005453-4057qib7 14041 4 of of IN cord-005453-4057qib7 14041 5 patients patient NNS cord-005453-4057qib7 14041 6 achieved achieve VBN cord-005453-4057qib7 14041 7 POS POS NNP cord-005453-4057qib7 14041 8 target target NN cord-005453-4057qib7 14041 9 trough trough IN cord-005453-4057qib7 14041 10 level level NN cord-005453-4057qib7 14041 11 of of IN cord-005453-4057qib7 14041 12 0.7 0.7 CD cord-005453-4057qib7 14041 13 mg mg NNP cord-005453-4057qib7 14041 14 / / SYM cord-005453-4057qib7 14041 15 L L NNP cord-005453-4057qib7 14041 16 after after IN cord-005453-4057qib7 14041 17 7 7 CD cord-005453-4057qib7 14041 18 days day NNS cord-005453-4057qib7 14041 19 of of IN cord-005453-4057qib7 14041 20 treatment treatment NN cord-005453-4057qib7 14041 21 with with IN cord-005453-4057qib7 14041 22 started start VBN cord-005453-4057qib7 14041 23 dose dose NN cord-005453-4057qib7 14041 24 4 4 CD cord-005453-4057qib7 14041 25 mg mg NNP cord-005453-4057qib7 14041 26 / / SYM cord-005453-4057qib7 14041 27 kg kg NNP cord-005453-4057qib7 14041 28 three three CD cord-005453-4057qib7 14041 29 times time NNS cord-005453-4057qib7 14041 30 a a DT cord-005453-4057qib7 14041 31 day day NN cord-005453-4057qib7 14041 32 . . . cord-005453-4057qib7 14042 1 Conclusions conclusion NNS cord-005453-4057qib7 14042 2 : : : cord-005453-4057qib7 14043 1 POS POS NNP cord-005453-4057qib7 14043 2 and and CC cord-005453-4057qib7 14043 3 FLU FLU NNP cord-005453-4057qib7 14043 4 are be VBP cord-005453-4057qib7 14043 5 comparably comparably RB cord-005453-4057qib7 14043 6 effective effective JJ cord-005453-4057qib7 14043 7 , , , cord-005453-4057qib7 14043 8 safety safety NN cord-005453-4057qib7 14043 9 and and CC cord-005453-4057qib7 14043 10 tolerability tolerability NN cord-005453-4057qib7 14043 11 in in IN cord-005453-4057qib7 14043 12 IFI IFI NNP cord-005453-4057qib7 14043 13 prophylaxis prophylaxis NN cord-005453-4057qib7 14043 14 in in IN cord-005453-4057qib7 14043 15 neutropenic neutropenic JJ cord-005453-4057qib7 14043 16 children child NNS cord-005453-4057qib7 14043 17 treated treat VBN cord-005453-4057qib7 14043 18 with with IN cord-005453-4057qib7 14043 19 HSCT HSCT NNP cord-005453-4057qib7 14043 20 . . . cord-005453-4057qib7 14044 1 Defining define VBG cord-005453-4057qib7 14044 2 dose dose NN cord-005453-4057qib7 14044 3 recommendation recommendation NN cord-005453-4057qib7 14044 4 of of IN cord-005453-4057qib7 14044 5 POS POS NNP cord-005453-4057qib7 14044 6 in in IN cord-005453-4057qib7 14044 7 this this DT cord-005453-4057qib7 14044 8 setting setting NN cord-005453-4057qib7 14044 9 requires require VBZ cord-005453-4057qib7 14044 10 larger large JJR cord-005453-4057qib7 14044 11 studies study NNS cord-005453-4057qib7 14044 12 . . . cord-005453-4057qib7 14045 1 Disclosure disclosure NN cord-005453-4057qib7 14045 2 Background background NN cord-005453-4057qib7 14045 3 : : : cord-005453-4057qib7 14046 1 Severe severe JJ cord-005453-4057qib7 14046 2 congenital congenital JJ cord-005453-4057qib7 14046 3 neutropenia neutropenia NN cord-005453-4057qib7 14046 4 ( ( -LRB- cord-005453-4057qib7 14046 5 SCN SCN NNP cord-005453-4057qib7 14046 6 ) ) -RRB- cord-005453-4057qib7 14046 7 is be VBZ cord-005453-4057qib7 14046 8 typically typically RB cord-005453-4057qib7 14046 9 characterized characterize VBN cord-005453-4057qib7 14046 10 by by IN cord-005453-4057qib7 14046 11 ANC ANC NNP cord-005453-4057qib7 14046 12 of of IN cord-005453-4057qib7 14046 13 < < XX cord-005453-4057qib7 14046 14 500 500 CD cord-005453-4057qib7 14047 1 /μl /μl NFP cord-005453-4057qib7 14047 2 , , , cord-005453-4057qib7 14047 3 maturation maturation NN cord-005453-4057qib7 14047 4 arrest arrest NN cord-005453-4057qib7 14047 5 of of IN cord-005453-4057qib7 14047 6 bone bone NN cord-005453-4057qib7 14047 7 marrow marrow NN cord-005453-4057qib7 14047 8 myeloid myeloid NN cord-005453-4057qib7 14047 9 precursors precursor NNS cord-005453-4057qib7 14047 10 at at IN cord-005453-4057qib7 14047 11 the the DT cord-005453-4057qib7 14047 12 promyelocyte promyelocyte NNP cord-005453-4057qib7 14047 13 - - HYPH cord-005453-4057qib7 14047 14 myelocyte myelocyte NNP cord-005453-4057qib7 14047 15 stage stage NN cord-005453-4057qib7 14047 16 , , , cord-005453-4057qib7 14047 17 and and CC cord-005453-4057qib7 14047 18 susceptibility susceptibility NN cord-005453-4057qib7 14047 19 to to IN cord-005453-4057qib7 14047 20 lethal lethal JJ cord-005453-4057qib7 14047 21 pyogenic pyogenic JJ cord-005453-4057qib7 14047 22 bacterial bacterial JJ cord-005453-4057qib7 14047 23 and and CC cord-005453-4057qib7 14047 24 fungal fungal JJ cord-005453-4057qib7 14047 25 infections infection NNS cord-005453-4057qib7 14047 26 . . . cord-005453-4057qib7 14048 1 SCN SCN NNP cord-005453-4057qib7 14048 2 is be VBZ cord-005453-4057qib7 14048 3 a a DT cord-005453-4057qib7 14048 4 rare rare JJ cord-005453-4057qib7 14048 5 group group NN cord-005453-4057qib7 14048 6 of of IN cord-005453-4057qib7 14048 7 disorders disorder NNS cord-005453-4057qib7 14048 8 resulting result VBG cord-005453-4057qib7 14048 9 from from IN cord-005453-4057qib7 14048 10 intrinsic intrinsic JJ cord-005453-4057qib7 14048 11 defects defect NNS cord-005453-4057qib7 14048 12 in in IN cord-005453-4057qib7 14048 13 myeloid myeloid JJ cord-005453-4057qib7 14048 14 cell cell NN cord-005453-4057qib7 14048 15 proliferation proliferation NN cord-005453-4057qib7 14048 16 and and CC cord-005453-4057qib7 14048 17 maturation maturation NN cord-005453-4057qib7 14048 18 caused cause VBN cord-005453-4057qib7 14048 19 by by IN cord-005453-4057qib7 14048 20 mutations mutation NNS cord-005453-4057qib7 14048 21 in in IN cord-005453-4057qib7 14048 22 several several JJ cord-005453-4057qib7 14048 23 genes gene NNS cord-005453-4057qib7 14048 24 ; ; : cord-005453-4057qib7 14048 25 ELANE ELANE NNP cord-005453-4057qib7 14048 26 , , , cord-005453-4057qib7 14048 27 HAX1 HAX1 NNP cord-005453-4057qib7 14048 28 , , , cord-005453-4057qib7 14048 29 GFI1 GFI1 NNP cord-005453-4057qib7 14048 30 , , , cord-005453-4057qib7 14048 31 WAS be VBD cord-005453-4057qib7 14048 32 , , , cord-005453-4057qib7 14048 33 and and CC cord-005453-4057qib7 14048 34 G6PC3 G6PC3 NNP cord-005453-4057qib7 14048 35 are be VBP cord-005453-4057qib7 14048 36 among among IN cord-005453-4057qib7 14048 37 the the DT cord-005453-4057qib7 14048 38 most most RBS cord-005453-4057qib7 14048 39 common common JJ cord-005453-4057qib7 14048 40 ones one NNS cord-005453-4057qib7 14048 41 . . . cord-005453-4057qib7 14049 1 Almost almost RB cord-005453-4057qib7 14049 2 10 10 CD cord-005453-4057qib7 14049 3 % % NN cord-005453-4057qib7 14049 4 of of IN cord-005453-4057qib7 14049 5 patients patient NNS cord-005453-4057qib7 14049 6 are be VBP cord-005453-4057qib7 14049 7 refractory refractory JJ cord-005453-4057qib7 14049 8 to to IN cord-005453-4057qib7 14049 9 G G NNP cord-005453-4057qib7 14049 10 - - HYPH cord-005453-4057qib7 14049 11 CSF CSF NNP cord-005453-4057qib7 14049 12 , , , cord-005453-4057qib7 14049 13 and and CC cord-005453-4057qib7 14049 14 the the DT cord-005453-4057qib7 14049 15 only only JJ cord-005453-4057qib7 14049 16 definitive definitive JJ cord-005453-4057qib7 14049 17 curative curative JJ cord-005453-4057qib7 14049 18 approach approach NN cord-005453-4057qib7 14049 19 for for IN cord-005453-4057qib7 14049 20 such such JJ cord-005453-4057qib7 14049 21 patients patient NNS cord-005453-4057qib7 14049 22 is be VBZ cord-005453-4057qib7 14049 23 allogeneic allogeneic IN cord-005453-4057qib7 14049 24 HSCT HSCT NNP cord-005453-4057qib7 14049 25 . . . cord-005453-4057qib7 14050 1 The the DT cord-005453-4057qib7 14050 2 current current JJ cord-005453-4057qib7 14050 3 absolute absolute JJ cord-005453-4057qib7 14050 4 indications indication NNS cord-005453-4057qib7 14050 5 for for IN cord-005453-4057qib7 14050 6 HSCT HSCT NNP cord-005453-4057qib7 14050 7 is be VBZ cord-005453-4057qib7 14050 8 failure failure NN cord-005453-4057qib7 14050 9 to to TO cord-005453-4057qib7 14050 10 respond respond VB cord-005453-4057qib7 14050 11 to to IN cord-005453-4057qib7 14050 12 G G NNP cord-005453-4057qib7 14050 13 - - HYPH cord-005453-4057qib7 14050 14 CSF csf NN cord-005453-4057qib7 14050 15 treatment treatment NN cord-005453-4057qib7 14050 16 , , , cord-005453-4057qib7 14050 17 or or CC cord-005453-4057qib7 14050 18 the the DT cord-005453-4057qib7 14050 19 development development NN cord-005453-4057qib7 14050 20 of of IN cord-005453-4057qib7 14050 21 MDS MDS NNP cord-005453-4057qib7 14050 22 / / SYM cord-005453-4057qib7 14050 23 leukemia leukemia NN cord-005453-4057qib7 14050 24 in in IN cord-005453-4057qib7 14050 25 patients patient NNS cord-005453-4057qib7 14050 26 with with IN cord-005453-4057qib7 14050 27 SCN SCN NNP cord-005453-4057qib7 14050 28 . . . cord-005453-4057qib7 14051 1 Here here RB cord-005453-4057qib7 14051 2 , , , cord-005453-4057qib7 14051 3 we -PRON- PRP cord-005453-4057qib7 14051 4 present present VBP cord-005453-4057qib7 14051 5 the the DT cord-005453-4057qib7 14051 6 result result NN cord-005453-4057qib7 14051 7 of of IN cord-005453-4057qib7 14051 8 10 10 CD cord-005453-4057qib7 14051 9 children child NNS cord-005453-4057qib7 14051 10 with with IN cord-005453-4057qib7 14051 11 SCN SCN NNP cord-005453-4057qib7 14051 12 who who WP cord-005453-4057qib7 14051 13 received receive VBD cord-005453-4057qib7 14051 14 allogeneic allogeneic IN cord-005453-4057qib7 14051 15 HSCT HSCT NNP cord-005453-4057qib7 14051 16 . . . cord-005453-4057qib7 14052 1 Methods method NNS cord-005453-4057qib7 14052 2 : : : cord-005453-4057qib7 14052 3 We -PRON- PRP cord-005453-4057qib7 14052 4 retrospectively retrospectively RB cord-005453-4057qib7 14052 5 assessed assess VBD cord-005453-4057qib7 14052 6 10 10 CD cord-005453-4057qib7 14052 7 allogeneic allogeneic IN cord-005453-4057qib7 14052 8 HSCT HSCT NNP cord-005453-4057qib7 14052 9 in in IN cord-005453-4057qib7 14052 10 children child NNS cord-005453-4057qib7 14052 11 with with IN cord-005453-4057qib7 14052 12 severe severe JJ cord-005453-4057qib7 14052 13 congenital congenital JJ cord-005453-4057qib7 14052 14 neutropenia neutropenia NN cord-005453-4057qib7 14052 15 . . . cord-005453-4057qib7 14053 1 All all DT cord-005453-4057qib7 14053 2 patients patient NNS cord-005453-4057qib7 14053 3 received receive VBD cord-005453-4057qib7 14053 4 busulphan busulphan NNP cord-005453-4057qib7 14053 5 ( ( -LRB- cord-005453-4057qib7 14053 6 BU BU NNP cord-005453-4057qib7 14053 7 ) ) -RRB- cord-005453-4057qib7 14053 8 based base VBD cord-005453-4057qib7 14053 9 myeloablative myeloablative NNP cord-005453-4057qib7 14053 10 conditioning conditioning NNP cord-005453-4057qib7 14053 11 regimen regimen NN cord-005453-4057qib7 14053 12 . . . cord-005453-4057qib7 14054 1 Busulphan Busulphan NNP cord-005453-4057qib7 14054 2 was be VBD cord-005453-4057qib7 14054 3 used use VBN cord-005453-4057qib7 14054 4 according accord VBG cord-005453-4057qib7 14054 5 to to IN cord-005453-4057qib7 14054 6 weight weight NN cord-005453-4057qib7 14054 7 adjusted adjust VBN cord-005453-4057qib7 14054 8 dose dose NN cord-005453-4057qib7 14054 9 . . . cord-005453-4057qib7 14055 1 In in IN cord-005453-4057qib7 14055 2 addition addition NN cord-005453-4057qib7 14055 3 , , , cord-005453-4057qib7 14055 4 all all DT cord-005453-4057qib7 14055 5 patients patient NNS cord-005453-4057qib7 14055 6 received receive VBD cord-005453-4057qib7 14055 7 fludarabine fludarabine NN cord-005453-4057qib7 14055 8 150 150 CD cord-005453-4057qib7 14055 9 mg mg NNP cord-005453-4057qib7 14055 10 / / SYM cord-005453-4057qib7 14055 11 m2 m2 NNP cord-005453-4057qib7 14055 12 in in IN cord-005453-4057qib7 14055 13 five five CD cord-005453-4057qib7 14055 14 days day NNS cord-005453-4057qib7 14055 15 or or CC cord-005453-4057qib7 14055 16 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 14055 17 200 200 CD cord-005453-4057qib7 14055 18 mg mg NNP cord-005453-4057qib7 14055 19 / / SYM cord-005453-4057qib7 14055 20 kg kg NNS cord-005453-4057qib7 14055 21 in in IN cord-005453-4057qib7 14055 22 4 4 CD cord-005453-4057qib7 14055 23 days day NNS cord-005453-4057qib7 14055 24 and and CC cord-005453-4057qib7 14055 25 ATG ATG NNP cord-005453-4057qib7 14055 26 30 30 CD cord-005453-4057qib7 14055 27 mg mg NNP cord-005453-4057qib7 14055 28 / / SYM cord-005453-4057qib7 14055 29 kg kg NN cord-005453-4057qib7 14055 30 in in IN cord-005453-4057qib7 14055 31 3 3 CD cord-005453-4057qib7 14055 32 days day NNS cord-005453-4057qib7 14055 33 . . . cord-005453-4057qib7 14056 1 Cyclosporin Cyclosporin NNP cord-005453-4057qib7 14056 2 - - HYPH cord-005453-4057qib7 14056 3 A A NNP cord-005453-4057qib7 14056 4 and and CC cord-005453-4057qib7 14056 5 MTX MTX NNP cord-005453-4057qib7 14056 6 were be VBD cord-005453-4057qib7 14056 7 used use VBN cord-005453-4057qib7 14056 8 for for IN cord-005453-4057qib7 14056 9 graft graft NN cord-005453-4057qib7 14056 10 versus versus IN cord-005453-4057qib7 14056 11 host host NN cord-005453-4057qib7 14056 12 disease disease NN cord-005453-4057qib7 14056 13 ( ( -LRB- cord-005453-4057qib7 14056 14 GVHD GVHD NNP cord-005453-4057qib7 14056 15 ) ) -RRB- cord-005453-4057qib7 14056 16 prophylaxis prophylaxis NN cord-005453-4057qib7 14056 17 . . . cord-005453-4057qib7 14057 1 Donor donor NN cord-005453-4057qib7 14057 2 chimerism chimerism NN cord-005453-4057qib7 14057 3 was be VBD cord-005453-4057qib7 14057 4 evaluated evaluate VBN cord-005453-4057qib7 14057 5 in in IN cord-005453-4057qib7 14057 6 either either DT cord-005453-4057qib7 14057 7 bone bone NN cord-005453-4057qib7 14057 8 marrow marrow NN cord-005453-4057qib7 14057 9 or or CC cord-005453-4057qib7 14057 10 peripheral peripheral JJ cord-005453-4057qib7 14057 11 blood blood NN cord-005453-4057qib7 14057 12 on on IN cord-005453-4057qib7 14057 13 days day NNS cord-005453-4057qib7 14057 14 +30 +30 CD cord-005453-4057qib7 14057 15 , , , cord-005453-4057qib7 14057 16 +100 +100 NNP cord-005453-4057qib7 14057 17 and and CC cord-005453-4057qib7 14058 1 +180 +180 NNP cord-005453-4057qib7 14058 2 . . . cord-005453-4057qib7 14058 3 Results result NNS cord-005453-4057qib7 14058 4 : : : cord-005453-4057qib7 14059 1 The the DT cord-005453-4057qib7 14059 2 median median JJ cord-005453-4057qib7 14059 3 transplantation transplantation NN cord-005453-4057qib7 14059 4 age age NN cord-005453-4057qib7 14059 5 of of IN cord-005453-4057qib7 14059 6 the the DT cord-005453-4057qib7 14059 7 patients patient NNS cord-005453-4057qib7 14059 8 was be VBD cord-005453-4057qib7 14059 9 49 49 CD cord-005453-4057qib7 14059 10 months month NNS cord-005453-4057qib7 14060 1 ( ( -LRB- cord-005453-4057qib7 14060 2 range range NNP cord-005453-4057qib7 14060 3 11 11 CD cord-005453-4057qib7 14060 4 - - SYM cord-005453-4057qib7 14060 5 167 167 CD cord-005453-4057qib7 14060 6 months month NNS cord-005453-4057qib7 14060 7 ) ) -RRB- cord-005453-4057qib7 14060 8 . . . cord-005453-4057qib7 14061 1 Six six CD cord-005453-4057qib7 14061 2 of of IN cord-005453-4057qib7 14061 3 them -PRON- PRP cord-005453-4057qib7 14061 4 are be VBP cord-005453-4057qib7 14061 5 male male JJ cord-005453-4057qib7 14061 6 . . . cord-005453-4057qib7 14062 1 Two two CD cord-005453-4057qib7 14062 2 of of IN cord-005453-4057qib7 14062 3 the the DT cord-005453-4057qib7 14062 4 donors donor NNS cord-005453-4057qib7 14062 5 were be VBD cord-005453-4057qib7 14062 6 matched match VBN cord-005453-4057qib7 14062 7 siblings sibling NNS cord-005453-4057qib7 14062 8 and and CC cord-005453-4057qib7 14062 9 8 8 CD cord-005453-4057qib7 14062 10 were be VBD cord-005453-4057qib7 14062 11 unrelated unrelated JJ cord-005453-4057qib7 14063 1 two two CD cord-005453-4057qib7 14063 2 of of IN cord-005453-4057qib7 14063 3 which which WDT cord-005453-4057qib7 14063 4 were be VBD cord-005453-4057qib7 14063 5 1 1 CD cord-005453-4057qib7 14063 6 ag ag NNP cord-005453-4057qib7 14063 7 1 1 CD cord-005453-4057qib7 14063 8 ag ag NNP cord-005453-4057qib7 14063 9 mismatched mismatch VBN cord-005453-4057qib7 14063 10 . . . cord-005453-4057qib7 14064 1 Stem stem JJ cord-005453-4057qib7 14064 2 cell cell NN cord-005453-4057qib7 14064 3 source source NN cord-005453-4057qib7 14064 4 was be VBD cord-005453-4057qib7 14064 5 bone bone NN cord-005453-4057qib7 14064 6 marrow marrow NN cord-005453-4057qib7 14064 7 in in IN cord-005453-4057qib7 14064 8 6 6 CD cord-005453-4057qib7 14064 9 patients patient NNS cord-005453-4057qib7 14064 10 , , , cord-005453-4057qib7 14064 11 peripheral peripheral JJ cord-005453-4057qib7 14064 12 blood blood NN cord-005453-4057qib7 14064 13 in in IN cord-005453-4057qib7 14064 14 2 2 CD cord-005453-4057qib7 14064 15 and and CC cord-005453-4057qib7 14064 16 cord cord NN cord-005453-4057qib7 14064 17 blood blood NN cord-005453-4057qib7 14064 18 in in IN cord-005453-4057qib7 14064 19 2 2 CD cord-005453-4057qib7 14064 20 patients patient NNS cord-005453-4057qib7 14064 21 . . . cord-005453-4057qib7 14065 1 All all DT cord-005453-4057qib7 14065 2 patients patient NNS cord-005453-4057qib7 14065 3 engrafted engraft VBD cord-005453-4057qib7 14065 4 . . . cord-005453-4057qib7 14066 1 The the DT cord-005453-4057qib7 14066 2 median median JJ cord-005453-4057qib7 14066 3 time time NN cord-005453-4057qib7 14066 4 of of IN cord-005453-4057qib7 14066 5 neutrophil neutrophil NN cord-005453-4057qib7 14066 6 and and CC cord-005453-4057qib7 14066 7 platelet platelet NN cord-005453-4057qib7 14066 8 engratment engratment NN cord-005453-4057qib7 14066 9 to to IN cord-005453-4057qib7 14066 10 was be VBD cord-005453-4057qib7 14066 11 15 15 CD cord-005453-4057qib7 14066 12 ( ( -LRB- cord-005453-4057qib7 14066 13 13 13 CD cord-005453-4057qib7 14066 14 - - SYM cord-005453-4057qib7 14066 15 34 34 CD cord-005453-4057qib7 14066 16 ) ) -RRB- cord-005453-4057qib7 14066 17 days day NNS cord-005453-4057qib7 14066 18 and and CC cord-005453-4057qib7 14066 19 16(9 16(9 CD cord-005453-4057qib7 14066 20 - - SYM cord-005453-4057qib7 14066 21 90 90 CD cord-005453-4057qib7 14066 22 ) ) -RRB- cord-005453-4057qib7 14066 23 days day NNS cord-005453-4057qib7 14066 24 , , , cord-005453-4057qib7 14066 25 respectively respectively RB cord-005453-4057qib7 14066 26 . . . cord-005453-4057qib7 14067 1 Graft graft NN cord-005453-4057qib7 14067 2 rejection rejection NN cord-005453-4057qib7 14067 3 was be VBD cord-005453-4057qib7 14067 4 experienced experience VBN cord-005453-4057qib7 14067 5 in in IN cord-005453-4057qib7 14067 6 2 2 CD cord-005453-4057qib7 14067 7 patients patient NNS cord-005453-4057qib7 14067 8 , , , cord-005453-4057qib7 14067 9 one one CD cord-005453-4057qib7 14067 10 of of IN cord-005453-4057qib7 14067 11 them -PRON- PRP cord-005453-4057qib7 14067 12 had have VBD cord-005453-4057qib7 14067 13 received receive VBN cord-005453-4057qib7 14067 14 unrelated unrelated JJ cord-005453-4057qib7 14067 15 cord cord NN cord-005453-4057qib7 14067 16 blood blood NN cord-005453-4057qib7 14067 17 . . . cord-005453-4057qib7 14068 1 All all DT cord-005453-4057qib7 14068 2 patients patient NNS cord-005453-4057qib7 14068 3 are be VBP cord-005453-4057qib7 14068 4 alive alive JJ cord-005453-4057qib7 14068 5 , , , cord-005453-4057qib7 14068 6 eight eight CD cord-005453-4057qib7 14068 7 of of IN cord-005453-4057qib7 14068 8 which which WDT cord-005453-4057qib7 14068 9 are be VBP cord-005453-4057qib7 14068 10 with with IN cord-005453-4057qib7 14068 11 full full JJ cord-005453-4057qib7 14068 12 donor donor NN cord-005453-4057qib7 14068 13 chimerism chimerism NN cord-005453-4057qib7 14068 14 ( ( -LRB- cord-005453-4057qib7 14068 15 between between IN cord-005453-4057qib7 14068 16 95 95 CD cord-005453-4057qib7 14068 17 - - SYM cord-005453-4057qib7 14068 18 100 100 CD cord-005453-4057qib7 14068 19 % % NN cord-005453-4057qib7 14068 20 ) ) -RRB- cord-005453-4057qib7 14068 21 without without IN cord-005453-4057qib7 14068 22 any any DT cord-005453-4057qib7 14068 23 complication complication NN cord-005453-4057qib7 14068 24 ( ( -LRB- cord-005453-4057qib7 14068 25 no no DT cord-005453-4057qib7 14068 26 infection infection NN cord-005453-4057qib7 14068 27 , , , cord-005453-4057qib7 14068 28 no no DT cord-005453-4057qib7 14068 29 GVHD GVHD NNP cord-005453-4057qib7 14068 30 ) ) -RRB- cord-005453-4057qib7 14068 31 with with IN cord-005453-4057qib7 14068 32 a a DT cord-005453-4057qib7 14068 33 median median JJ cord-005453-4057qib7 14068 34 40 40 CD cord-005453-4057qib7 14068 35 months month NNS cord-005453-4057qib7 14069 1 ( ( -LRB- cord-005453-4057qib7 14069 2 range range VBP cord-005453-4057qib7 14069 3 24 24 CD cord-005453-4057qib7 14069 4 - - SYM cord-005453-4057qib7 14069 5 83 83 CD cord-005453-4057qib7 14069 6 months month NNS cord-005453-4057qib7 14069 7 ) ) -RRB- cord-005453-4057qib7 14069 8 follow follow VBP cord-005453-4057qib7 14069 9 up up RP cord-005453-4057qib7 14069 10 . . . cord-005453-4057qib7 14070 1 Probability probability NN cord-005453-4057qib7 14070 2 of of IN cord-005453-4057qib7 14070 3 disease disease NN cord-005453-4057qib7 14070 4 free free JJ cord-005453-4057qib7 14070 5 and and CC cord-005453-4057qib7 14070 6 overall overall JJ cord-005453-4057qib7 14070 7 survival survival NN cord-005453-4057qib7 14070 8 were be VBD cord-005453-4057qib7 14070 9 found find VBN cord-005453-4057qib7 14070 10 80 80 CD cord-005453-4057qib7 14070 11 % % NN cord-005453-4057qib7 14070 12 and and CC cord-005453-4057qib7 14070 13 100 100 CD cord-005453-4057qib7 14070 14 % % NN cord-005453-4057qib7 14070 15 , , , cord-005453-4057qib7 14070 16 respectively respectively RB cord-005453-4057qib7 14070 17 . . . cord-005453-4057qib7 14071 1 Conclusions conclusion NNS cord-005453-4057qib7 14071 2 : : : cord-005453-4057qib7 14072 1 We -PRON- PRP cord-005453-4057qib7 14072 2 concluded conclude VBD cord-005453-4057qib7 14072 3 that that IN cord-005453-4057qib7 14072 4 HSCT HSCT NNP cord-005453-4057qib7 14072 5 is be VBZ cord-005453-4057qib7 14072 6 a a DT cord-005453-4057qib7 14072 7 useful useful JJ cord-005453-4057qib7 14072 8 treatment treatment NN cord-005453-4057qib7 14072 9 for for IN cord-005453-4057qib7 14072 10 SCN SCN NNP cord-005453-4057qib7 14072 11 patients patient NNS cord-005453-4057qib7 14072 12 , , , cord-005453-4057qib7 14072 13 especially especially RB cord-005453-4057qib7 14072 14 those those DT cord-005453-4057qib7 14072 15 who who WP cord-005453-4057qib7 14072 16 are be VBP cord-005453-4057qib7 14072 17 unresponsive unresponsive JJ cord-005453-4057qib7 14072 18 to to IN cord-005453-4057qib7 14072 19 GCSF GCSF NNP cord-005453-4057qib7 14072 20 treatment treatment NN cord-005453-4057qib7 14072 21 and and CC cord-005453-4057qib7 14072 22 at at IN cord-005453-4057qib7 14072 23 high high JJ cord-005453-4057qib7 14072 24 risk risk NN cord-005453-4057qib7 14072 25 for for IN cord-005453-4057qib7 14072 26 leukemic leukemic JJ cord-005453-4057qib7 14072 27 transformation transformation NN cord-005453-4057qib7 14072 28 . . . cord-005453-4057qib7 14073 1 However however RB cord-005453-4057qib7 14073 2 , , , cord-005453-4057qib7 14073 3 a a DT cord-005453-4057qib7 14073 4 larger large JJR cord-005453-4057qib7 14073 5 number number NN cord-005453-4057qib7 14073 6 of of IN cord-005453-4057qib7 14073 7 SCN SCN NNP cord-005453-4057qib7 14073 8 patients patient NNS cord-005453-4057qib7 14073 9 and and CC cord-005453-4057qib7 14073 10 longer long RBR cord-005453-4057qib7 14073 11 follow follow VB cord-005453-4057qib7 14073 12 - - HYPH cord-005453-4057qib7 14073 13 up up NN cord-005453-4057qib7 14073 14 are be VBP cord-005453-4057qib7 14073 15 necessary necessary JJ cord-005453-4057qib7 14073 16 to to TO cord-005453-4057qib7 14073 17 identify identify VB cord-005453-4057qib7 14073 18 appropriate appropriate JJ cord-005453-4057qib7 14073 19 conditioning conditioning NN cord-005453-4057qib7 14073 20 regimens regimen NNS cord-005453-4057qib7 14073 21 and and CC cord-005453-4057qib7 14073 22 long long JJ cord-005453-4057qib7 14073 23 - - HYPH cord-005453-4057qib7 14073 24 term term NN cord-005453-4057qib7 14073 25 prognosis prognosis NN cord-005453-4057qib7 14073 26 . . . cord-005453-4057qib7 14074 1 Disclosure disclosure NN cord-005453-4057qib7 14074 2 : : : cord-005453-4057qib7 14074 3 Nothing nothing NN cord-005453-4057qib7 14074 4 to to TO cord-005453-4057qib7 14074 5 declare declare VB cord-005453-4057qib7 14074 6 Background background NN cord-005453-4057qib7 14074 7 : : : cord-005453-4057qib7 14075 1 Prolonged prolonged JJ cord-005453-4057qib7 14075 2 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 14075 3 ( ( -LRB- cord-005453-4057qib7 14075 4 PT pt NN cord-005453-4057qib7 14075 5 ) ) -RRB- cord-005453-4057qib7 14075 6 or or CC cord-005453-4057qib7 14075 7 secondary secondary JJ cord-005453-4057qib7 14075 8 failure failure NN cord-005453-4057qib7 14075 9 of of IN cord-005453-4057qib7 14075 10 platelet platelet NN cord-005453-4057qib7 14075 11 recovery recovery NN cord-005453-4057qib7 14075 12 ( ( -LRB- cord-005453-4057qib7 14075 13 SFPR SFPR NNP cord-005453-4057qib7 14075 14 ) ) -RRB- cord-005453-4057qib7 14075 15 are be VBP cord-005453-4057qib7 14075 16 a a DT cord-005453-4057qib7 14075 17 lifethreatening lifethreatening JJ cord-005453-4057qib7 14075 18 complications complication NNS cord-005453-4057qib7 14075 19 that that WDT cord-005453-4057qib7 14075 20 occurs occur VBZ cord-005453-4057qib7 14075 21 in in IN cord-005453-4057qib7 14075 22 20 20 CD cord-005453-4057qib7 14075 23 - - SYM cord-005453-4057qib7 14075 24 40 40 CD cord-005453-4057qib7 14075 25 % % NN cord-005453-4057qib7 14075 26 and and CC cord-005453-4057qib7 14075 27 12 12 CD cord-005453-4057qib7 14075 28 - - SYM cord-005453-4057qib7 14075 29 20 20 CD cord-005453-4057qib7 14075 30 % % NN cord-005453-4057qib7 14075 31 respectively respectively RB cord-005453-4057qib7 14075 32 of of IN cord-005453-4057qib7 14075 33 the the DT cord-005453-4057qib7 14075 34 patients patient NNS cord-005453-4057qib7 14075 35 following follow VBG cord-005453-4057qib7 14075 36 allogeneic allogeneic IN cord-005453-4057qib7 14075 37 hematopoietic hematopoietic JJ cord-005453-4057qib7 14075 38 stem stem NN cord-005453-4057qib7 14075 39 cell cell NN cord-005453-4057qib7 14075 40 transplantation transplantation NN cord-005453-4057qib7 14075 41 ( ( -LRB- cord-005453-4057qib7 14075 42 allo allo NN cord-005453-4057qib7 14075 43 - - HYPH cord-005453-4057qib7 14075 44 HSCT HSCT NNP cord-005453-4057qib7 14075 45 ) ) -RRB- cord-005453-4057qib7 14075 46 . . . cord-005453-4057qib7 14076 1 Management management NN cord-005453-4057qib7 14076 2 strategies strategy NNS cord-005453-4057qib7 14076 3 , , , cord-005453-4057qib7 14076 4 including include VBG cord-005453-4057qib7 14076 5 the the DT cord-005453-4057qib7 14076 6 use use NN cord-005453-4057qib7 14076 7 of of IN cord-005453-4057qib7 14076 8 growth growth NN cord-005453-4057qib7 14076 9 factors factor NNS cord-005453-4057qib7 14076 10 , , , cord-005453-4057qib7 14076 11 CD34 CD34 NNP cord-005453-4057qib7 14076 12 + + CC cord-005453-4057qib7 14076 13 -selected -selected JJ cord-005453-4057qib7 14076 14 stem stem NN cord-005453-4057qib7 14076 15 cell cell NN cord-005453-4057qib7 14076 16 boost boost NN cord-005453-4057qib7 14076 17 , , , cord-005453-4057qib7 14076 18 mesenchymal mesenchymal JJ cord-005453-4057qib7 14076 19 stem stem NN cord-005453-4057qib7 14076 20 cell cell NN cord-005453-4057qib7 14076 21 ( ( -LRB- cord-005453-4057qib7 14076 22 MSC MSC NNP cord-005453-4057qib7 14076 23 ) ) -RRB- cord-005453-4057qib7 14076 24 transfusion transfusion NN cord-005453-4057qib7 14076 25 , , , cord-005453-4057qib7 14076 26 and and CC cord-005453-4057qib7 14076 27 second second JJ cord-005453-4057qib7 14076 28 allo allo NN cord-005453-4057qib7 14076 29 - - HYPH cord-005453-4057qib7 14076 30 HSCT HSCT NNP cord-005453-4057qib7 14076 31 , , , cord-005453-4057qib7 14076 32 are be VBP cord-005453-4057qib7 14076 33 not not RB cord-005453-4057qib7 14076 34 effective effective JJ cord-005453-4057qib7 14076 35 or or CC cord-005453-4057qib7 14076 36 possible possible JJ cord-005453-4057qib7 14076 37 for for IN cord-005453-4057qib7 14076 38 all all DT cord-005453-4057qib7 14076 39 patients patient NNS cord-005453-4057qib7 14076 40 . . . cord-005453-4057qib7 14077 1 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14077 2 , , , cord-005453-4057qib7 14077 3 is be VBZ cord-005453-4057qib7 14077 4 an an DT cord-005453-4057qib7 14077 5 oral oral JJ cord-005453-4057qib7 14077 6 non non JJ cord-005453-4057qib7 14077 7 - - JJ cord-005453-4057qib7 14077 8 peptide peptide JJ cord-005453-4057qib7 14077 9 thrombopoietin thrombopoietin NNP cord-005453-4057qib7 14077 10 receptor receptor NN cord-005453-4057qib7 14077 11 agonist agonist NN cord-005453-4057qib7 14077 12 , , , cord-005453-4057qib7 14077 13 that that WDT cord-005453-4057qib7 14077 14 leads lead VBZ cord-005453-4057qib7 14077 15 to to TO cord-005453-4057qib7 14077 16 signal signal VB cord-005453-4057qib7 14077 17 transduction transduction NN cord-005453-4057qib7 14077 18 and and CC cord-005453-4057qib7 14077 19 results result NNS cord-005453-4057qib7 14077 20 in in IN cord-005453-4057qib7 14077 21 promoting promote VBG cord-005453-4057qib7 14077 22 the the DT cord-005453-4057qib7 14077 23 proliferation proliferation NN cord-005453-4057qib7 14077 24 and and CC cord-005453-4057qib7 14077 25 differentiation differentiation NN cord-005453-4057qib7 14077 26 of of IN cord-005453-4057qib7 14077 27 megakaryocytes megakaryocyte NNS cord-005453-4057qib7 14077 28 . . . cord-005453-4057qib7 14078 1 Some some DT cord-005453-4057qib7 14078 2 recently recently RB cord-005453-4057qib7 14078 3 studies study NNS cord-005453-4057qib7 14078 4 show show VBP cord-005453-4057qib7 14078 5 that that IN cord-005453-4057qib7 14078 6 also also RB cord-005453-4057qib7 14078 7 can can MD cord-005453-4057qib7 14078 8 promote promote VB cord-005453-4057qib7 14078 9 haematopoiesis haematopoiesis NN cord-005453-4057qib7 14078 10 along along IN cord-005453-4057qib7 14078 11 all all DT cord-005453-4057qib7 14078 12 three three CD cord-005453-4057qib7 14078 13 lineages lineage NNS cord-005453-4057qib7 14078 14 . . . cord-005453-4057qib7 14079 1 Methods method NNS cord-005453-4057qib7 14080 1 : : : cord-005453-4057qib7 14080 2 We -PRON- PRP cord-005453-4057qib7 14080 3 described describe VBD cord-005453-4057qib7 14080 4 our -PRON- PRP$ cord-005453-4057qib7 14080 5 experience experience NN cord-005453-4057qib7 14080 6 in in IN cord-005453-4057qib7 14080 7 4 4 CD cord-005453-4057qib7 14080 8 paediatric paediatric JJ cord-005453-4057qib7 14080 9 patients patient NNS cord-005453-4057qib7 14080 10 with with IN cord-005453-4057qib7 14080 11 poor poor JJ cord-005453-4057qib7 14080 12 graft graft NN cord-005453-4057qib7 14080 13 function function NN cord-005453-4057qib7 14080 14 or or CC cord-005453-4057qib7 14080 15 secondary secondary JJ cord-005453-4057qib7 14080 16 failure failure NN cord-005453-4057qib7 14080 17 of of IN cord-005453-4057qib7 14080 18 platelet platelet NN cord-005453-4057qib7 14080 19 recovery recovery NN cord-005453-4057qib7 14080 20 after after IN cord-005453-4057qib7 14080 21 allogeneic allogeneic NN cord-005453-4057qib7 14080 22 stem stem NN cord-005453-4057qib7 14080 23 cell cell NN cord-005453-4057qib7 14080 24 transplantation transplantation NN cord-005453-4057qib7 14080 25 treated treat VBN cord-005453-4057qib7 14080 26 with with IN cord-005453-4057qib7 14080 27 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14080 28 . . . cord-005453-4057qib7 14081 1 Results result NNS cord-005453-4057qib7 14081 2 : : : cord-005453-4057qib7 14082 1 Patients patient NNS cord-005453-4057qib7 14082 2 characteristics characteristic NNS cord-005453-4057qib7 14082 3 are be VBP cord-005453-4057qib7 14082 4 detailed detail VBN cord-005453-4057qib7 14082 5 in in IN cord-005453-4057qib7 14082 6 Table Table NNP cord-005453-4057qib7 14082 7 1 1 CD cord-005453-4057qib7 14082 8 . . . cord-005453-4057qib7 14083 1 All all PDT cord-005453-4057qib7 14083 2 the the DT cord-005453-4057qib7 14083 3 patients patient NNS cord-005453-4057qib7 14083 4 received receive VBN cord-005453-4057qib7 14083 5 and and CC cord-005453-4057qib7 14083 6 allo allo NN cord-005453-4057qib7 14083 7 - - HYPH cord-005453-4057qib7 14083 8 HST HST NNP cord-005453-4057qib7 14083 9 . . . cord-005453-4057qib7 14084 1 The the DT cord-005453-4057qib7 14084 2 median median JJ cord-005453-4057qib7 14084 3 dose dose NN cord-005453-4057qib7 14084 4 of of IN cord-005453-4057qib7 14084 5 CD34 CD34 NNP cord-005453-4057qib7 14084 6 + + CC cord-005453-4057qib7 14085 1 cells cell NNS cord-005453-4057qib7 14085 2 infusion infusion NN cord-005453-4057qib7 14085 3 was be VBD cord-005453-4057qib7 14085 4 6.43x10e6 6.43x10e6 NNP cord-005453-4057qib7 14085 5 / / SYM cord-005453-4057qib7 14085 6 kg kg NN cord-005453-4057qib7 14085 7 ( ( -LRB- cord-005453-4057qib7 14085 8 3.95 3.95 CD cord-005453-4057qib7 14085 9 - - SYM cord-005453-4057qib7 14085 10 8.29 8.29 CD cord-005453-4057qib7 14085 11 ) ) -RRB- cord-005453-4057qib7 14085 12 . . . cord-005453-4057qib7 14086 1 Neutrophils neutrophils NN cord-005453-4057qib7 14086 2 engraftment engraftment NN cord-005453-4057qib7 14086 3 occurred occur VBD cord-005453-4057qib7 14086 4 in in IN cord-005453-4057qib7 14086 5 +15 +15 CD cord-005453-4057qib7 14086 6 day day NN cord-005453-4057qib7 14086 7 ( ( -LRB- cord-005453-4057qib7 14086 8 10 10 CD cord-005453-4057qib7 14086 9 - - HYPH cord-005453-4057qib7 14086 10 21d 21d CD cord-005453-4057qib7 14086 11 ) ) -RRB- cord-005453-4057qib7 14086 12 and and CC cord-005453-4057qib7 14086 13 platelets platelet NNS cord-005453-4057qib7 14086 14 in in IN cord-005453-4057qib7 14086 15 +26 +26 NNP cord-005453-4057qib7 14086 16 day day NN cord-005453-4057qib7 14086 17 ( ( -LRB- cord-005453-4057qib7 14086 18 16 16 CD cord-005453-4057qib7 14086 19 - - HYPH cord-005453-4057qib7 14086 20 42d 42d CD cord-005453-4057qib7 14086 21 ) ) -RRB- cord-005453-4057qib7 14086 22 . . . cord-005453-4057qib7 14087 1 All all PDT cord-005453-4057qib7 14087 2 the the DT cord-005453-4057qib7 14087 3 patients patient NNS cord-005453-4057qib7 14087 4 had have VBD cord-005453-4057qib7 14087 5 an an DT cord-005453-4057qib7 14087 6 hypoplastic hypoplastic JJ cord-005453-4057qib7 14087 7 bone bone NN cord-005453-4057qib7 14087 8 marrow marrow NN cord-005453-4057qib7 14087 9 with with IN cord-005453-4057qib7 14087 10 complete complete JJ cord-005453-4057qib7 14087 11 chimerism chimerism NN cord-005453-4057qib7 14087 12 . . . cord-005453-4057qib7 14088 1 The the DT cord-005453-4057qib7 14088 2 median median JJ cord-005453-4057qib7 14088 3 duration duration NN cord-005453-4057qib7 14088 4 from from IN cord-005453-4057qib7 14088 5 transplantation transplantation NN cord-005453-4057qib7 14088 6 to to IN cord-005453-4057qib7 14088 7 SPCF SPCF NNP cord-005453-4057qib7 14088 8 diagnosis diagnosis NN cord-005453-4057qib7 14088 9 was be VBD cord-005453-4057qib7 14088 10 10 10 CD cord-005453-4057qib7 14088 11 months month NNS cord-005453-4057qib7 14088 12 ( ( -LRB- cord-005453-4057qib7 14088 13 1.5 1.5 CD cord-005453-4057qib7 14088 14 - - SYM cord-005453-4057qib7 14088 15 24 24 CD cord-005453-4057qib7 14088 16 m m CD cord-005453-4057qib7 14088 17 ) ) -RRB- cord-005453-4057qib7 14088 18 . . . cord-005453-4057qib7 14089 1 One one CD cord-005453-4057qib7 14089 2 of of IN cord-005453-4057qib7 14089 3 the the DT cord-005453-4057qib7 14089 4 patients patient NNS cord-005453-4057qib7 14089 5 received receive VBD cord-005453-4057qib7 14089 6 a a DT cord-005453-4057qib7 14089 7 stem stem NN cord-005453-4057qib7 14089 8 cell cell NN cord-005453-4057qib7 14089 9 boost boost NN cord-005453-4057qib7 14089 10 prior prior RB cord-005453-4057qib7 14089 11 to to IN cord-005453-4057qib7 14089 12 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14089 13 , , , cord-005453-4057qib7 14089 14 without without IN cord-005453-4057qib7 14089 15 response response NN cord-005453-4057qib7 14089 16 . . . cord-005453-4057qib7 14090 1 The the DT cord-005453-4057qib7 14090 2 time time NN cord-005453-4057qib7 14090 3 onset onset NN cord-005453-4057qib7 14090 4 from from IN cord-005453-4057qib7 14090 5 sPGF sPGF NNP cord-005453-4057qib7 14090 6 / / SYM cord-005453-4057qib7 14090 7 sFPR sfpr NN cord-005453-4057qib7 14090 8 diagnosis diagnosis NN cord-005453-4057qib7 14090 9 to to IN cord-005453-4057qib7 14090 10 initiating initiate VBG cord-005453-4057qib7 14090 11 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14090 12 was be VBD cord-005453-4057qib7 14090 13 16 16 CD cord-005453-4057qib7 14090 14 days day NNS cord-005453-4057qib7 14090 15 ( ( -LRB- cord-005453-4057qib7 14090 16 8 8 CD cord-005453-4057qib7 14090 17 - - SYM cord-005453-4057qib7 14090 18 32d 32d CD cord-005453-4057qib7 14090 19 ) ) -RRB- cord-005453-4057qib7 14090 20 . . . cord-005453-4057qib7 14091 1 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14091 2 was be VBD cord-005453-4057qib7 14091 3 started start VBN cord-005453-4057qib7 14091 4 at at IN cord-005453-4057qib7 14091 5 a a DT cord-005453-4057qib7 14091 6 dose dose NN cord-005453-4057qib7 14091 7 of of IN cord-005453-4057qib7 14091 8 1mg 1mg NNP cord-005453-4057qib7 14091 9 / / SYM cord-005453-4057qib7 14091 10 kg kg NNP cord-005453-4057qib7 14091 11 / / SYM cord-005453-4057qib7 14091 12 d d NNP cord-005453-4057qib7 14091 13 , , , cord-005453-4057qib7 14091 14 requiring require VBG cord-005453-4057qib7 14091 15 an an DT cord-005453-4057qib7 14091 16 increase increase NN cord-005453-4057qib7 14091 17 dose dose NN cord-005453-4057qib7 14091 18 in in IN cord-005453-4057qib7 14091 19 all all DT cord-005453-4057qib7 14091 20 cases case NNS cord-005453-4057qib7 14091 21 . . . cord-005453-4057qib7 14092 1 The the DT cord-005453-4057qib7 14092 2 median median JJ cord-005453-4057qib7 14092 3 dose dose NN cord-005453-4057qib7 14092 4 was be VBD cord-005453-4057qib7 14092 5 50 50 CD cord-005453-4057qib7 14092 6 mg mg NN cord-005453-4057qib7 14092 7 / / SYM cord-005453-4057qib7 14092 8 d d NN cord-005453-4057qib7 14092 9 ( ( -LRB- cord-005453-4057qib7 14092 10 25 25 CD cord-005453-4057qib7 14092 11 - - SYM cord-005453-4057qib7 14092 12 100 100 CD cord-005453-4057qib7 14092 13 mg mg NNP cord-005453-4057qib7 14092 14 ) ) -RRB- cord-005453-4057qib7 14092 15 . . . cord-005453-4057qib7 14093 1 The the DT cord-005453-4057qib7 14093 2 overall overall JJ cord-005453-4057qib7 14093 3 response response NN cord-005453-4057qib7 14093 4 rate rate NN cord-005453-4057qib7 14093 5 was be VBD cord-005453-4057qib7 14093 6 50 50 CD cord-005453-4057qib7 14093 7 % % NN cord-005453-4057qib7 14093 8 ( ( -LRB- cord-005453-4057qib7 14093 9 2/4 2/4 CD cord-005453-4057qib7 14093 10 ) ) -RRB- cord-005453-4057qib7 14093 11 . . . cord-005453-4057qib7 14094 1 Two two CD cord-005453-4057qib7 14094 2 patients patient NNS cord-005453-4057qib7 14094 3 achieved achieve VBD cord-005453-4057qib7 14094 4 complete complete JJ cord-005453-4057qib7 14094 5 response response NN cord-005453-4057qib7 14094 6 ( ( -LRB- cord-005453-4057qib7 14094 7 CR CR NNP cord-005453-4057qib7 14094 8 ) ) -RRB- cord-005453-4057qib7 14094 9 , , , cord-005453-4057qib7 14094 10 as as IN cord-005453-4057qib7 14094 11 defined define VBN cord-005453-4057qib7 14094 12 by by IN cord-005453-4057qib7 14094 13 platelet platelet NN cord-005453-4057qib7 14095 1 ≥ ≥ CD cord-005453-4057qib7 14095 2 50 50 CD cord-005453-4057qib7 14095 3 × × NN cord-005453-4057qib7 14095 4 109 109 CD cord-005453-4057qib7 14096 1 /L. /L. . cord-005453-4057qib7 14097 1 Both both DT cord-005453-4057qib7 14097 2 patients patient NNS cord-005453-4057qib7 14097 3 already already RB cord-005453-4057qib7 14097 4 got get VBD cord-005453-4057qib7 14097 5 neutrophil neutrophil NN cord-005453-4057qib7 14097 6 ≥ ≥ NNP cord-005453-4057qib7 14097 7 1.0 1.0 CD cord-005453-4057qib7 14097 8 × × NN cord-005453-4057qib7 14097 9 109 109 CD cord-005453-4057qib7 14097 10 / / SYM cord-005453-4057qib7 14097 11 L l NN cord-005453-4057qib7 14097 12 without without IN cord-005453-4057qib7 14097 13 G G NNP cord-005453-4057qib7 14097 14 - - HYPH cord-005453-4057qib7 14097 15 CSF CSF NNP cord-005453-4057qib7 14097 16 . . . cord-005453-4057qib7 14098 1 The the DT cord-005453-4057qib7 14098 2 time time NN cord-005453-4057qib7 14098 3 from from IN cord-005453-4057qib7 14098 4 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14098 5 initiation initiation NN cord-005453-4057qib7 14098 6 to to IN cord-005453-4057qib7 14098 7 achieving achieve VBG cord-005453-4057qib7 14098 8 CR CR NNP cord-005453-4057qib7 14098 9 was be VBD cord-005453-4057qib7 14098 10 21 21 CD cord-005453-4057qib7 14098 11 ( ( -LRB- cord-005453-4057qib7 14098 12 10 10 CD cord-005453-4057qib7 14098 13 - - SYM cord-005453-4057qib7 14098 14 49d 49d CD cord-005453-4057qib7 14098 15 ) ) -RRB- cord-005453-4057qib7 14098 16 days day NNS cord-005453-4057qib7 14098 17 . . . cord-005453-4057qib7 14099 1 The the DT cord-005453-4057qib7 14099 2 treatment treatment NN cord-005453-4057qib7 14099 3 was be VBD cord-005453-4057qib7 14099 4 given give VBN cord-005453-4057qib7 14099 5 for for IN cord-005453-4057qib7 14099 6 a a DT cord-005453-4057qib7 14099 7 median median NN cord-005453-4057qib7 14099 8 of of IN cord-005453-4057qib7 14099 9 81 81 CD cord-005453-4057qib7 14099 10 days day NNS cord-005453-4057qib7 14099 11 ( ( -LRB- cord-005453-4057qib7 14099 12 8 8 CD cord-005453-4057qib7 14099 13 - - SYM cord-005453-4057qib7 14099 14 203 203 CD cord-005453-4057qib7 14099 15 ) ) -RRB- cord-005453-4057qib7 14099 16 . . . cord-005453-4057qib7 14100 1 It -PRON- PRP cord-005453-4057qib7 14100 2 was be VBD cord-005453-4057qib7 14100 3 discontinued discontinue VBN cord-005453-4057qib7 14100 4 after after IN cord-005453-4057qib7 14100 5 96 96 CD cord-005453-4057qib7 14100 6 and and CC cord-005453-4057qib7 14100 7 203 203 CD cord-005453-4057qib7 14100 8 days day NNS cord-005453-4057qib7 14100 9 respectively respectively RB cord-005453-4057qib7 14100 10 in in IN cord-005453-4057qib7 14100 11 the the DT cord-005453-4057qib7 14100 12 two two CD cord-005453-4057qib7 14100 13 responder responder NN cord-005453-4057qib7 14100 14 patients patient NNS cord-005453-4057qib7 14100 15 . . . cord-005453-4057qib7 14101 1 Both both DT cord-005453-4057qib7 14101 2 patients patient NNS cord-005453-4057qib7 14101 3 maintain maintain VBP cord-005453-4057qib7 14101 4 stable stable JJ cord-005453-4057qib7 14101 5 blood blood NN cord-005453-4057qib7 14101 6 counts count NNS cord-005453-4057qib7 14101 7 after after IN cord-005453-4057qib7 14101 8 discontinuing discontinue VBG cord-005453-4057qib7 14101 9 the the DT cord-005453-4057qib7 14101 10 treatment treatment NN cord-005453-4057qib7 14101 11 . . . cord-005453-4057qib7 14102 1 The the DT cord-005453-4057qib7 14102 2 non non JJ cord-005453-4057qib7 14102 3 - - NNS cord-005453-4057qib7 14102 4 responders responder NNS cord-005453-4057qib7 14102 5 patients patient NNS cord-005453-4057qib7 14102 6 had have VBD cord-005453-4057qib7 14102 7 to to TO cord-005453-4057qib7 14102 8 stop stop VB cord-005453-4057qib7 14102 9 the the DT cord-005453-4057qib7 14102 10 treatment treatment NN cord-005453-4057qib7 14102 11 because because IN cord-005453-4057qib7 14102 12 of of IN cord-005453-4057qib7 14102 13 other other JJ cord-005453-4057qib7 14102 14 reasons reason NNS cord-005453-4057qib7 14102 15 not not RB cord-005453-4057qib7 14102 16 related relate VBN cord-005453-4057qib7 14102 17 to to IN cord-005453-4057qib7 14102 18 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14102 19 . . . cord-005453-4057qib7 14103 1 Patient patient NN cord-005453-4057qib7 14103 2 4 4 CD cord-005453-4057qib7 14103 3 had have VBD cord-005453-4057qib7 14103 4 to to TO cord-005453-4057qib7 14103 5 be be VB cord-005453-4057qib7 14103 6 rescued rescue VBN cord-005453-4057qib7 14103 7 with with IN cord-005453-4057qib7 14103 8 a a DT cord-005453-4057qib7 14103 9 CD34 CD34 NNP cord-005453-4057qib7 14104 1 + + CC cord-005453-4057qib7 14104 2 cells cell NNS cord-005453-4057qib7 14104 3 boost boost VBP cord-005453-4057qib7 14104 4 with with IN cord-005453-4057qib7 14104 5 a a DT cord-005453-4057qib7 14104 6 good good JJ cord-005453-4057qib7 14104 7 response response NN cord-005453-4057qib7 14104 8 . . . cord-005453-4057qib7 14105 1 Two two CD cord-005453-4057qib7 14105 2 patients patient NNS cord-005453-4057qib7 14105 3 that that WDT cord-005453-4057qib7 14105 4 were be VBD cord-005453-4057qib7 14105 5 in in IN cord-005453-4057qib7 14105 6 treatment treatment NN cord-005453-4057qib7 14105 7 with with IN cord-005453-4057qib7 14105 8 voriconazole voriconazole NN cord-005453-4057qib7 14105 9 for for IN cord-005453-4057qib7 14105 10 a a DT cord-005453-4057qib7 14105 11 fungal fungal JJ cord-005453-4057qib7 14105 12 infection infection NN cord-005453-4057qib7 14105 13 developed develop VBD cord-005453-4057qib7 14105 14 hyperbilirubinemia hyperbilirubinemia NN cord-005453-4057qib7 14105 15 . . . cord-005453-4057qib7 14106 1 There there EX cord-005453-4057qib7 14106 2 were be VBD cord-005453-4057qib7 14106 3 no no DT cord-005453-4057qib7 14106 4 grade grade NN cord-005453-4057qib7 14106 5 3 3 CD cord-005453-4057qib7 14106 6 - - SYM cord-005453-4057qib7 14106 7 4 4 CD cord-005453-4057qib7 14106 8 toxicities toxicity NNS cord-005453-4057qib7 14106 9 related relate VBN cord-005453-4057qib7 14106 10 to to IN cord-005453-4057qib7 14106 11 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14106 12 . . . cord-005453-4057qib7 14107 1 Conclusions conclusion NNS cord-005453-4057qib7 14107 2 : : : cord-005453-4057qib7 14108 1 In in IN cord-005453-4057qib7 14108 2 our -PRON- PRP$ cord-005453-4057qib7 14108 3 experience experience NN cord-005453-4057qib7 14108 4 , , , cord-005453-4057qib7 14108 5 according accord VBG cord-005453-4057qib7 14108 6 to to IN cord-005453-4057qib7 14108 7 recently recently RB cord-005453-4057qib7 14108 8 published publish VBN cord-005453-4057qib7 14108 9 studies study NNS cord-005453-4057qib7 14108 10 , , , cord-005453-4057qib7 14108 11 Eltrombopag Eltrombopag NNP cord-005453-4057qib7 14108 12 is be VBZ cord-005453-4057qib7 14108 13 a a DT cord-005453-4057qib7 14108 14 safe safe JJ cord-005453-4057qib7 14108 15 and and CC cord-005453-4057qib7 14108 16 efficacy efficacy NN cord-005453-4057qib7 14108 17 drug drug NN cord-005453-4057qib7 14108 18 in in IN cord-005453-4057qib7 14108 19 the the DT cord-005453-4057qib7 14108 20 treatment treatment NN cord-005453-4057qib7 14108 21 of of IN cord-005453-4057qib7 14108 22 secondary secondary JJ cord-005453-4057qib7 14108 23 failure failure NN cord-005453-4057qib7 14108 24 of of IN cord-005453-4057qib7 14108 25 platelet platelet NN cord-005453-4057qib7 14108 26 recovery recovery NN cord-005453-4057qib7 14108 27 post post NN cord-005453-4057qib7 14108 28 - - JJ cord-005453-4057qib7 14108 29 HSCT HSCT NNP cord-005453-4057qib7 14108 30 . . . cord-005453-4057qib7 14109 1 It -PRON- PRP cord-005453-4057qib7 14109 2 may may MD cord-005453-4057qib7 14109 3 be be VB cord-005453-4057qib7 14109 4 used use VBN cord-005453-4057qib7 14109 5 successfully successfully RB cord-005453-4057qib7 14109 6 in in IN cord-005453-4057qib7 14109 7 children child NNS cord-005453-4057qib7 14109 8 . . . cord-005453-4057qib7 14110 1 Sometimes sometimes RB cord-005453-4057qib7 14110 2 higher high JJR cord-005453-4057qib7 14110 3 doses dose NNS cord-005453-4057qib7 14110 4 may may MD cord-005453-4057qib7 14110 5 be be VB cord-005453-4057qib7 14110 6 considered consider VBN cord-005453-4057qib7 14110 7 if if IN cord-005453-4057qib7 14110 8 no no DT cord-005453-4057qib7 14110 9 response response NN cord-005453-4057qib7 14110 10 is be VBZ cord-005453-4057qib7 14110 11 achieved achieve VBN cord-005453-4057qib7 14110 12 . . . cord-005453-4057qib7 14111 1 Further further JJ cord-005453-4057qib7 14111 2 prospective prospective JJ cord-005453-4057qib7 14111 3 trials trial NNS cord-005453-4057qib7 14111 4 are be VBP cord-005453-4057qib7 14111 5 needed need VBN cord-005453-4057qib7 14111 6 to to TO cord-005453-4057qib7 14111 7 increase increase VB cord-005453-4057qib7 14111 8 the the DT cord-005453-4057qib7 14111 9 level level NN cord-005453-4057qib7 14111 10 of of IN cord-005453-4057qib7 14111 11 evidence evidence NN cord-005453-4057qib7 14111 12 and and CC cord-005453-4057qib7 14111 13 to to TO cord-005453-4057qib7 14111 14 identify identify VB cord-005453-4057qib7 14111 15 predictors predictor NNS cord-005453-4057qib7 14111 16 of of IN cord-005453-4057qib7 14111 17 response response NN cord-005453-4057qib7 14111 18 . . . cord-005453-4057qib7 14112 1 Disclosure disclosure NN cord-005453-4057qib7 14112 2 : : : cord-005453-4057qib7 14112 3 Nothing nothing NN cord-005453-4057qib7 14112 4 to to TO cord-005453-4057qib7 14112 5 declare declare VB cord-005453-4057qib7 14112 6 Very very RB cord-005453-4057qib7 14112 7 slow slow JJ cord-005453-4057qib7 14112 8 clearance clearance NN cord-005453-4057qib7 14112 9 of of IN cord-005453-4057qib7 14112 10 busulfan busulfan NN cord-005453-4057qib7 14112 11 in in IN cord-005453-4057qib7 14112 12 a a DT cord-005453-4057qib7 14112 13 child child NN cord-005453-4057qib7 14112 14 with with IN cord-005453-4057qib7 14112 15 infant infant NN cord-005453-4057qib7 14112 16 leukemia leukemia NN cord-005453-4057qib7 14112 17 Background background NN cord-005453-4057qib7 14112 18 : : : cord-005453-4057qib7 14112 19 Busulfan Busulfan NNP cord-005453-4057qib7 14112 20 is be VBZ cord-005453-4057qib7 14112 21 a a DT cord-005453-4057qib7 14112 22 drug drug NN cord-005453-4057qib7 14112 23 with with IN cord-005453-4057qib7 14112 24 a a DT cord-005453-4057qib7 14112 25 high high JJ cord-005453-4057qib7 14112 26 interindividual interindividual JJ cord-005453-4057qib7 14112 27 variability variability NN cord-005453-4057qib7 14112 28 between between IN cord-005453-4057qib7 14112 29 dose dose NN cord-005453-4057qib7 14112 30 and and CC cord-005453-4057qib7 14112 31 exposition exposition NN cord-005453-4057qib7 14112 32 . . . cord-005453-4057qib7 14113 1 Therefore therefore RB cord-005453-4057qib7 14113 2 , , , cord-005453-4057qib7 14113 3 it -PRON- PRP cord-005453-4057qib7 14113 4 is be VBZ cord-005453-4057qib7 14113 5 recommended recommend VBN cord-005453-4057qib7 14113 6 to to TO cord-005453-4057qib7 14113 7 perform perform VB cord-005453-4057qib7 14113 8 therapeutic therapeutic JJ cord-005453-4057qib7 14113 9 drug drug NN cord-005453-4057qib7 14113 10 monitoring monitoring NN cord-005453-4057qib7 14113 11 ( ( -LRB- cord-005453-4057qib7 14113 12 TDM TDM NNP cord-005453-4057qib7 14113 13 ) ) -RRB- cord-005453-4057qib7 14113 14 in in IN cord-005453-4057qib7 14113 15 the the DT cord-005453-4057qib7 14113 16 context context NN cord-005453-4057qib7 14113 17 of of IN cord-005453-4057qib7 14113 18 myeloablative myeloablative JJ cord-005453-4057qib7 14113 19 conditioning conditioning NN cord-005453-4057qib7 14113 20 , , , cord-005453-4057qib7 14113 21 especially especially RB cord-005453-4057qib7 14113 22 in in IN cord-005453-4057qib7 14113 23 children child NNS cord-005453-4057qib7 14113 24 . . . cord-005453-4057qib7 14114 1 Methods method NNS cord-005453-4057qib7 14115 1 : : : cord-005453-4057qib7 14115 2 We -PRON- PRP cord-005453-4057qib7 14115 3 report report VBP cord-005453-4057qib7 14115 4 on on IN cord-005453-4057qib7 14115 5 a a DT cord-005453-4057qib7 14115 6 7-month 7-month NNP cord-005453-4057qib7 14115 7 old old JJ cord-005453-4057qib7 14115 8 boy boy NN cord-005453-4057qib7 14115 9 ( ( -LRB- cord-005453-4057qib7 14115 10 7.2 7.2 CD cord-005453-4057qib7 14115 11 kg kg NNS cord-005453-4057qib7 14115 12 , , , cord-005453-4057qib7 14115 13 66 66 CD cord-005453-4057qib7 14115 14 cm cm NNS cord-005453-4057qib7 14115 15 ) ) -RRB- cord-005453-4057qib7 14115 16 of of IN cord-005453-4057qib7 14115 17 caucasian caucasian JJ cord-005453-4057qib7 14115 18 decent decent JJ cord-005453-4057qib7 14115 19 born bear VBN cord-005453-4057qib7 14115 20 to to IN cord-005453-4057qib7 14115 21 non non JJ cord-005453-4057qib7 14115 22 - - JJ cord-005453-4057qib7 14115 23 consanguine consanguine JJ cord-005453-4057qib7 14115 24 parents parent NNS cord-005453-4057qib7 14115 25 with with IN cord-005453-4057qib7 14115 26 MLL MLL NNP cord-005453-4057qib7 14115 27 - - HYPH cord-005453-4057qib7 14115 28 rearranged rearrange VBN cord-005453-4057qib7 14115 29 proB prob JJ cord-005453-4057qib7 14115 30 - - HYPH cord-005453-4057qib7 14115 31 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 14115 32 leukemia leukemia NN cord-005453-4057qib7 14115 33 . . . cord-005453-4057qib7 14116 1 Diagnosis diagnosis NN cord-005453-4057qib7 14116 2 was be VBD cord-005453-4057qib7 14116 3 established establish VBN cord-005453-4057qib7 14116 4 one one CD cord-005453-4057qib7 14116 5 month month NN cord-005453-4057qib7 14116 6 after after IN cord-005453-4057qib7 14116 7 birth birth NN cord-005453-4057qib7 14116 8 from from IN cord-005453-4057qib7 14116 9 peripheral peripheral JJ cord-005453-4057qib7 14116 10 blood blood NN cord-005453-4057qib7 14116 11 and and CC cord-005453-4057qib7 14116 12 CSF CSF NNP cord-005453-4057qib7 14116 13 tap tap NN cord-005453-4057qib7 14116 14 showed show VBD cord-005453-4057qib7 14116 15 CNS CNS NNP cord-005453-4057qib7 14116 16 involvement involvement NN cord-005453-4057qib7 14116 17 . . . cord-005453-4057qib7 14117 1 Primary primary JJ cord-005453-4057qib7 14117 2 chemotherapy chemotherapy NN cord-005453-4057qib7 14117 3 was be VBD cord-005453-4057qib7 14117 4 commenced commence VBN cord-005453-4057qib7 14117 5 according accord VBG cord-005453-4057qib7 14117 6 to to IN cord-005453-4057qib7 14117 7 the the DT cord-005453-4057qib7 14117 8 Interfant-06 Interfant-06 NNP cord-005453-4057qib7 14117 9 protocol protocol NN cord-005453-4057qib7 14117 10 . . . cord-005453-4057qib7 14118 1 However however RB cord-005453-4057qib7 14118 2 , , , cord-005453-4057qib7 14118 3 MRD MRD NNP cord-005453-4057qib7 14118 4 remained remain VBD cord-005453-4057qib7 14118 5 positive positive JJ cord-005453-4057qib7 14118 6 two two CD cord-005453-4057qib7 14118 7 months month NNS cord-005453-4057qib7 14118 8 under under IN cord-005453-4057qib7 14118 9 treatment treatment NN cord-005453-4057qib7 14118 10 , , , cord-005453-4057qib7 14118 11 leading lead VBG cord-005453-4057qib7 14118 12 to to IN cord-005453-4057qib7 14118 13 an an DT cord-005453-4057qib7 14118 14 indication indication NN cord-005453-4057qib7 14118 15 for for IN cord-005453-4057qib7 14118 16 allogeneic allogeneic NN cord-005453-4057qib7 14118 17 stem stem NN cord-005453-4057qib7 14118 18 cell cell NN cord-005453-4057qib7 14118 19 transplantation transplantation NN cord-005453-4057qib7 14118 20 . . . cord-005453-4057qib7 14119 1 In in IN cord-005453-4057qib7 14119 2 the the DT cord-005453-4057qib7 14119 3 Interfant-06 interfant-06 NN cord-005453-4057qib7 14119 4 protocol protocol NN cord-005453-4057qib7 14119 5 , , , cord-005453-4057qib7 14119 6 we -PRON- PRP cord-005453-4057qib7 14119 7 opted opt VBD cord-005453-4057qib7 14119 8 for for IN cord-005453-4057qib7 14119 9 a a DT cord-005453-4057qib7 14119 10 conditioning conditioning NN cord-005453-4057qib7 14119 11 regimen regimen NN cord-005453-4057qib7 14119 12 comprised comprise VBN cord-005453-4057qib7 14119 13 of of IN cord-005453-4057qib7 14119 14 fludarabine fludarabine NN cord-005453-4057qib7 14119 15 ( ( -LRB- cord-005453-4057qib7 14119 16 1.2 1.2 CD cord-005453-4057qib7 14119 17 mg mg NNP cord-005453-4057qib7 14119 18 / / SYM cord-005453-4057qib7 14119 19 kg kg NN cord-005453-4057qib7 14119 20 for for IN cord-005453-4057qib7 14119 21 5 5 CD cord-005453-4057qib7 14119 22 days day NNS cord-005453-4057qib7 14119 23 ) ) -RRB- cord-005453-4057qib7 14119 24 , , , cord-005453-4057qib7 14119 25 busulfan busulfan NN cord-005453-4057qib7 14119 26 and and CC cord-005453-4057qib7 14119 27 thiotepa thiotepa NNP cord-005453-4057qib7 14119 28 ( ( -LRB- cord-005453-4057qib7 14119 29 2x5 2x5 CD cord-005453-4057qib7 14119 30 mg mg NNP cord-005453-4057qib7 14119 31 / / SYM cord-005453-4057qib7 14119 32 kg kg NNP cord-005453-4057qib7 14119 33 ) ) -RRB- cord-005453-4057qib7 14119 34 . . . cord-005453-4057qib7 14120 1 In in IN cord-005453-4057qib7 14120 2 our -PRON- PRP$ cord-005453-4057qib7 14120 3 institution institution NN cord-005453-4057qib7 14120 4 , , , cord-005453-4057qib7 14120 5 busulfan busulfan NNP cord-005453-4057qib7 14120 6 is be VBZ cord-005453-4057qib7 14120 7 applied apply VBN cord-005453-4057qib7 14120 8 once once RB cord-005453-4057qib7 14120 9 daily daily RB cord-005453-4057qib7 14120 10 with with IN cord-005453-4057qib7 14120 11 a a DT cord-005453-4057qib7 14120 12 target target NN cord-005453-4057qib7 14120 13 AUC AUC NNP cord-005453-4057qib7 14120 14 of of IN cord-005453-4057qib7 14120 15 85 85 CD cord-005453-4057qib7 14120 16 - - SYM cord-005453-4057qib7 14120 17 95 95 CD cord-005453-4057qib7 14120 18 h*mg h*mg NN cord-005453-4057qib7 14120 19 / / SYM cord-005453-4057qib7 14120 20 l l NN cord-005453-4057qib7 14120 21 in in IN cord-005453-4057qib7 14120 22 this this DT cord-005453-4057qib7 14120 23 very very RB cord-005453-4057qib7 14120 24 high high JJ cord-005453-4057qib7 14120 25 risk risk NN cord-005453-4057qib7 14120 26 situation situation NN cord-005453-4057qib7 14120 27 . . . cord-005453-4057qib7 14121 1 According accord VBG cord-005453-4057qib7 14121 2 to to IN cord-005453-4057qib7 14121 3 body body NN cord-005453-4057qib7 14121 4 weight weight NN cord-005453-4057qib7 14121 5 , , , cord-005453-4057qib7 14121 6 busulfan busulfan NN cord-005453-4057qib7 14121 7 was be VBD cord-005453-4057qib7 14121 8 given give VBN cord-005453-4057qib7 14121 9 with with IN cord-005453-4057qib7 14121 10 5.1 5.1 CD cord-005453-4057qib7 14121 11 mg/ mg/ NN cord-005453-4057qib7 14121 12 kg kg NNP cord-005453-4057qib7 14121 13 as as IN cord-005453-4057qib7 14121 14 a a DT cord-005453-4057qib7 14121 15 three three CD cord-005453-4057qib7 14121 16 - - HYPH cord-005453-4057qib7 14121 17 hour hour NN cord-005453-4057qib7 14121 18 infusion infusion NN cord-005453-4057qib7 14121 19 on on IN cord-005453-4057qib7 14121 20 the the DT cord-005453-4057qib7 14121 21 first first JJ cord-005453-4057qib7 14121 22 day day NN cord-005453-4057qib7 14121 23 . . . cord-005453-4057qib7 14122 1 Busulfan Busulfan NNP cord-005453-4057qib7 14122 2 concentrations concentration NNS cord-005453-4057qib7 14122 3 in in IN cord-005453-4057qib7 14122 4 plasma plasma NN cord-005453-4057qib7 14122 5 were be VBD cord-005453-4057qib7 14122 6 measured measure VBN cord-005453-4057qib7 14122 7 with with IN cord-005453-4057qib7 14122 8 gas gas NN cord-005453-4057qib7 14122 9 chromatography chromatography NN cord-005453-4057qib7 14122 10 - - HYPH cord-005453-4057qib7 14122 11 mass mass NN cord-005453-4057qib7 14122 12 spectrometry spectrometry NN cord-005453-4057qib7 14122 13 ( ( -LRB- cord-005453-4057qib7 14122 14 GC GC NNP cord-005453-4057qib7 14122 15 - - HYPH cord-005453-4057qib7 14122 16 MS MS NNP cord-005453-4057qib7 14122 17 ) ) -RRB- cord-005453-4057qib7 14122 18 and and CC cord-005453-4057qib7 14122 19 AUC AUC NNP cord-005453-4057qib7 14122 20 was be VBD cord-005453-4057qib7 14122 21 calculated calculate VBN cord-005453-4057qib7 14122 22 using use VBG cord-005453-4057qib7 14122 23 Bayesian Bayesian NNP cord-005453-4057qib7 14122 24 curve curve NN cord-005453-4057qib7 14122 25 fitting fitting NN cord-005453-4057qib7 14122 26 . . . cord-005453-4057qib7 14123 1 Results result NNS cord-005453-4057qib7 14123 2 : : : cord-005453-4057qib7 14124 1 Exact exact JJ cord-005453-4057qib7 14124 2 busulfan busulfan NN cord-005453-4057qib7 14124 3 quantification quantification NN cord-005453-4057qib7 14124 4 was be VBD cord-005453-4057qib7 14124 5 not not RB cord-005453-4057qib7 14124 6 possible possible JJ cord-005453-4057qib7 14124 7 after after IN cord-005453-4057qib7 14124 8 the the DT cord-005453-4057qib7 14124 9 first first JJ cord-005453-4057qib7 14124 10 dose dose NN cord-005453-4057qib7 14124 11 due due IN cord-005453-4057qib7 14124 12 to to IN cord-005453-4057qib7 14124 13 technical technical JJ cord-005453-4057qib7 14124 14 reasons reason NNS cord-005453-4057qib7 14124 15 . . . cord-005453-4057qib7 14125 1 As as IN cord-005453-4057qib7 14125 2 the the DT cord-005453-4057qib7 14125 3 levels level NNS cord-005453-4057qib7 14125 4 were be VBD cord-005453-4057qib7 14125 5 estimated estimate VBN cord-005453-4057qib7 14125 6 to to TO cord-005453-4057qib7 14125 7 be be VB cord-005453-4057qib7 14125 8 very very RB cord-005453-4057qib7 14125 9 high high JJ cord-005453-4057qib7 14125 10 , , , cord-005453-4057qib7 14125 11 we -PRON- PRP cord-005453-4057qib7 14125 12 decided decide VBD cord-005453-4057qib7 14125 13 to to TO cord-005453-4057qib7 14125 14 reduce reduce VB cord-005453-4057qib7 14125 15 the the DT cord-005453-4057qib7 14125 16 second second JJ cord-005453-4057qib7 14125 17 dose dose NN cord-005453-4057qib7 14125 18 of of IN cord-005453-4057qib7 14125 19 busulfan busulfan NN cord-005453-4057qib7 14125 20 by by IN cord-005453-4057qib7 14125 21 25 25 CD cord-005453-4057qib7 14125 22 % % NN cord-005453-4057qib7 14125 23 . . . cord-005453-4057qib7 14126 1 This this DT cord-005453-4057qib7 14126 2 resulted result VBD cord-005453-4057qib7 14126 3 in in IN cord-005453-4057qib7 14126 4 a a DT cord-005453-4057qib7 14126 5 very very RB cord-005453-4057qib7 14126 6 high high JJ cord-005453-4057qib7 14126 7 AUC auc NN cord-005453-4057qib7 14126 8 of of IN cord-005453-4057qib7 14126 9 44 44 CD cord-005453-4057qib7 14126 10 h*mg h*mg NNP cord-005453-4057qib7 14126 11 / / SYM cord-005453-4057qib7 14126 12 l l NN cord-005453-4057qib7 14126 13 for for IN cord-005453-4057qib7 14126 14 the the DT cord-005453-4057qib7 14126 15 second second JJ cord-005453-4057qib7 14126 16 dose dose NN cord-005453-4057qib7 14126 17 , , , cord-005453-4057qib7 14126 18 so so IN cord-005453-4057qib7 14126 19 that that DT cord-005453-4057qib7 14126 20 busulfan busulfan NN cord-005453-4057qib7 14126 21 was be VBD cord-005453-4057qib7 14126 22 discontinued discontinue VBN cord-005453-4057qib7 14126 23 after after IN cord-005453-4057qib7 14126 24 two two CD cord-005453-4057qib7 14126 25 days day NNS cord-005453-4057qib7 14126 26 , , , cord-005453-4057qib7 14126 27 because because IN cord-005453-4057qib7 14126 28 it -PRON- PRP cord-005453-4057qib7 14126 29 was be VBD cord-005453-4057qib7 14126 30 calculated calculate VBN cord-005453-4057qib7 14126 31 that that IN cord-005453-4057qib7 14126 32 the the DT cord-005453-4057qib7 14126 33 patient patient NN cord-005453-4057qib7 14126 34 already already RB cord-005453-4057qib7 14126 35 received receive VBD cord-005453-4057qib7 14126 36 busulfan busulfan NN cord-005453-4057qib7 14126 37 with with IN cord-005453-4057qib7 14126 38 a a DT cord-005453-4057qib7 14126 39 cumulative cumulative JJ cord-005453-4057qib7 14126 40 AUC auc NN cord-005453-4057qib7 14126 41 of of IN cord-005453-4057qib7 14126 42 90 90 CD cord-005453-4057qib7 14126 43 h*mg h*mg NN cord-005453-4057qib7 14126 44 / / SYM cord-005453-4057qib7 14126 45 ml ml NN cord-005453-4057qib7 14126 46 . . . cord-005453-4057qib7 14127 1 Trough trough NN cord-005453-4057qib7 14127 2 levels level NNS cord-005453-4057qib7 14127 3 after after IN cord-005453-4057qib7 14127 4 the the DT cord-005453-4057qib7 14127 5 first first JJ cord-005453-4057qib7 14127 6 and and CC cord-005453-4057qib7 14127 7 second second JJ cord-005453-4057qib7 14127 8 dose dose NN cord-005453-4057qib7 14127 9 were be VBD cord-005453-4057qib7 14127 10 547 547 CD cord-005453-4057qib7 14127 11 and and CC cord-005453-4057qib7 14127 12 572 572 CD cord-005453-4057qib7 14127 13 μg μg NNP cord-005453-4057qib7 14127 14 / / SYM cord-005453-4057qib7 14127 15 l l NN cord-005453-4057qib7 14127 16 , , , cord-005453-4057qib7 14127 17 respectively respectively RB cord-005453-4057qib7 14127 18 . . . cord-005453-4057qib7 14128 1 The the DT cord-005453-4057qib7 14128 2 patient patient NN cord-005453-4057qib7 14128 3 showed show VBD cord-005453-4057qib7 14128 4 a a DT cord-005453-4057qib7 14128 5 very very RB cord-005453-4057qib7 14128 6 slow slow JJ cord-005453-4057qib7 14128 7 clearance clearance NN cord-005453-4057qib7 14128 8 of of IN cord-005453-4057qib7 14128 9 2.1 2.1 CD cord-005453-4057qib7 14128 10 l l NN cord-005453-4057qib7 14128 11 / / SYM cord-005453-4057qib7 14128 12 h h NN cord-005453-4057qib7 14128 13 / / SYM cord-005453-4057qib7 14128 14 sqm sqm NN cord-005453-4057qib7 14128 15 , , , cord-005453-4057qib7 14128 16 while while IN cord-005453-4057qib7 14128 17 the the DT cord-005453-4057qib7 14128 18 volume volume NN cord-005453-4057qib7 14128 19 of of IN cord-005453-4057qib7 14128 20 distribution distribution NN cord-005453-4057qib7 14128 21 was be VBD cord-005453-4057qib7 14128 22 in in IN cord-005453-4057qib7 14128 23 the the DT cord-005453-4057qib7 14128 24 usual usual JJ cord-005453-4057qib7 14128 25 range range NN cord-005453-4057qib7 14128 26 ( ( -LRB- cord-005453-4057qib7 14128 27 0.86 0.86 CD cord-005453-4057qib7 14128 28 l l NN cord-005453-4057qib7 14128 29 / / SYM cord-005453-4057qib7 14128 30 kg kg NNP cord-005453-4057qib7 14128 31 ) ) -RRB- cord-005453-4057qib7 14128 32 . . . cord-005453-4057qib7 14129 1 Bilirubin bilirubin NN cord-005453-4057qib7 14129 2 and and CC cord-005453-4057qib7 14129 3 liver liver NN cord-005453-4057qib7 14129 4 transaminases transaminase NNS cord-005453-4057qib7 14129 5 were be VBD cord-005453-4057qib7 14129 6 in in IN cord-005453-4057qib7 14129 7 the the DT cord-005453-4057qib7 14129 8 normal normal JJ cord-005453-4057qib7 14129 9 range range NN cord-005453-4057qib7 14129 10 at at IN cord-005453-4057qib7 14129 11 the the DT cord-005453-4057qib7 14129 12 time time NN cord-005453-4057qib7 14129 13 of of IN cord-005453-4057qib7 14129 14 conditioning conditioning NN cord-005453-4057qib7 14129 15 , , , cord-005453-4057qib7 14129 16 while while IN cord-005453-4057qib7 14129 17 albumin albumin NN cord-005453-4057qib7 14129 18 and and CC cord-005453-4057qib7 14129 19 Quick quick JJ cord-005453-4057qib7 14129 20 were be VBD cord-005453-4057qib7 14129 21 decreased decrease VBN cord-005453-4057qib7 14129 22 On on IN cord-005453-4057qib7 14129 23 day day NN cord-005453-4057qib7 14129 24 +18 +18 CD cord-005453-4057qib7 14129 25 after after IN cord-005453-4057qib7 14129 26 transplantation transplantation NN cord-005453-4057qib7 14129 27 the the DT cord-005453-4057qib7 14129 28 patient patient NN cord-005453-4057qib7 14129 29 developed develop VBD cord-005453-4057qib7 14129 30 clinical clinical JJ cord-005453-4057qib7 14129 31 und und IN cord-005453-4057qib7 14129 32 biochemical biochemical JJ cord-005453-4057qib7 14129 33 signs sign NNS cord-005453-4057qib7 14129 34 of of IN cord-005453-4057qib7 14129 35 venoocclusive venoocclusive JJ cord-005453-4057qib7 14129 36 disease disease NN cord-005453-4057qib7 14129 37 ( ( -LRB- cord-005453-4057qib7 14129 38 VOD VOD NNP cord-005453-4057qib7 14129 39 ) ) -RRB- cord-005453-4057qib7 14129 40 . . . cord-005453-4057qib7 14130 1 VOD VOD NNP cord-005453-4057qib7 14130 2 symptoms symptom NNS cord-005453-4057qib7 14130 3 completely completely RB cord-005453-4057qib7 14130 4 resolved resolve VBN cord-005453-4057qib7 14130 5 under under IN cord-005453-4057qib7 14130 6 therapy therapy NN cord-005453-4057qib7 14130 7 with with IN cord-005453-4057qib7 14130 8 defibrotide defibrotide NNP cord-005453-4057qib7 14130 9 . . . cord-005453-4057qib7 14131 1 Leukocyte Leukocyte NNP cord-005453-4057qib7 14131 2 engraftment engraftment NN cord-005453-4057qib7 14131 3 was be VBD cord-005453-4057qib7 14131 4 established establish VBN cord-005453-4057qib7 14131 5 on on IN cord-005453-4057qib7 14131 6 day day NN cord-005453-4057qib7 14131 7 +14 +14 CD cord-005453-4057qib7 14131 8 . . . cord-005453-4057qib7 14132 1 Unfortunately unfortunately RB cord-005453-4057qib7 14132 2 , , , cord-005453-4057qib7 14132 3 the the DT cord-005453-4057qib7 14132 4 patients patient NNS cord-005453-4057qib7 14132 5 suffered suffer VBD cord-005453-4057qib7 14132 6 from from IN cord-005453-4057qib7 14132 7 an an DT cord-005453-4057qib7 14132 8 early early JJ cord-005453-4057qib7 14132 9 relapse relapse NN cord-005453-4057qib7 14132 10 of of IN cord-005453-4057qib7 14132 11 the the DT cord-005453-4057qib7 14132 12 leukemia leukemia NN cord-005453-4057qib7 14132 13 from from IN cord-005453-4057qib7 14132 14 day day NN cord-005453-4057qib7 14132 15 +62 +62 NNP cord-005453-4057qib7 14132 16 . . . cord-005453-4057qib7 14133 1 Attempts attempt NNS cord-005453-4057qib7 14133 2 to to TO cord-005453-4057qib7 14133 3 induce induce VB cord-005453-4057qib7 14133 4 a a DT cord-005453-4057qib7 14133 5 second second JJ cord-005453-4057qib7 14133 6 remission remission NN cord-005453-4057qib7 14133 7 with with IN cord-005453-4057qib7 14133 8 blinatumomab blinatumomab NNS cord-005453-4057qib7 14133 9 failed fail VBD cord-005453-4057qib7 14133 10 . . . cord-005453-4057qib7 14134 1 The the DT cord-005453-4057qib7 14134 2 patient patient NN cord-005453-4057qib7 14134 3 is be VBZ cord-005453-4057qib7 14134 4 currently currently RB cord-005453-4057qib7 14134 5 under under IN cord-005453-4057qib7 14134 6 palliative palliative JJ cord-005453-4057qib7 14134 7 chemotherapy chemotherapy NN cord-005453-4057qib7 14134 8 . . . cord-005453-4057qib7 14135 1 Conclusions conclusion NNS cord-005453-4057qib7 14135 2 : : : cord-005453-4057qib7 14136 1 Busulfan Busulfan NNP cord-005453-4057qib7 14136 2 TDM TDM NNP cord-005453-4057qib7 14136 3 is be VBZ cord-005453-4057qib7 14136 4 very very RB cord-005453-4057qib7 14136 5 important important JJ cord-005453-4057qib7 14136 6 especially especially RB cord-005453-4057qib7 14136 7 in in IN cord-005453-4057qib7 14136 8 infants infant NNS cord-005453-4057qib7 14136 9 receiving receive VBG cord-005453-4057qib7 14136 10 myeloablative myeloablative JJ cord-005453-4057qib7 14136 11 doses dose NNS cord-005453-4057qib7 14136 12 of of IN cord-005453-4057qib7 14136 13 busulfan busulfan NN cord-005453-4057qib7 14136 14 to to TO cord-005453-4057qib7 14136 15 prevent prevent VB cord-005453-4057qib7 14136 16 under under NN cord-005453-4057qib7 14136 17 - - HYPH cord-005453-4057qib7 14136 18 or or CC cord-005453-4057qib7 14136 19 over over IN cord-005453-4057qib7 14136 20 - - HYPH cord-005453-4057qib7 14136 21 exposure exposure NN cord-005453-4057qib7 14136 22 . . . cord-005453-4057qib7 14137 1 There there EX cord-005453-4057qib7 14137 2 is be VBZ cord-005453-4057qib7 14137 3 evidence evidence NN cord-005453-4057qib7 14137 4 that that IN cord-005453-4057qib7 14137 5 high high JJ cord-005453-4057qib7 14137 6 busulfan busulfan NN cord-005453-4057qib7 14137 7 trough trough NN cord-005453-4057qib7 14137 8 levels level NNS cord-005453-4057qib7 14137 9 contribute contribute VBP cord-005453-4057qib7 14137 10 to to IN cord-005453-4057qib7 14137 11 the the DT cord-005453-4057qib7 14137 12 development development NN cord-005453-4057qib7 14137 13 of of IN cord-005453-4057qib7 14137 14 VOD VOD NNP cord-005453-4057qib7 14137 15 , , , cord-005453-4057qib7 14137 16 but but CC cord-005453-4057qib7 14137 17 anti anti JJ cord-005453-4057qib7 14137 18 - - JJ cord-005453-4057qib7 14137 19 leukemic leukemic JJ cord-005453-4057qib7 14137 20 activity activity NN cord-005453-4057qib7 14137 21 of of IN cord-005453-4057qib7 14137 22 busulfan busulfan NN cord-005453-4057qib7 14137 23 and and CC cord-005453-4057qib7 14137 24 CNS CNS NNP cord-005453-4057qib7 14137 25 permeability permeability NN cord-005453-4057qib7 14137 26 make make VBP cord-005453-4057qib7 14137 27 it -PRON- PRP cord-005453-4057qib7 14137 28 a a DT cord-005453-4057qib7 14137 29 valuable valuable JJ cord-005453-4057qib7 14137 30 drug drug NN cord-005453-4057qib7 14137 31 for for IN cord-005453-4057qib7 14137 32 very very RB cord-005453-4057qib7 14137 33 high high JJ cord-005453-4057qib7 14137 34 risk risk NN cord-005453-4057qib7 14137 35 patients patient NNS cord-005453-4057qib7 14137 36 in in IN cord-005453-4057qib7 14137 37 childhood childhood NN cord-005453-4057qib7 14137 38 leukemia leukemia NN cord-005453-4057qib7 14137 39 . . . cord-005453-4057qib7 14138 1 Larger large JJR cord-005453-4057qib7 14138 2 patient patient JJ cord-005453-4057qib7 14138 3 cohorts cohort NNS cord-005453-4057qib7 14138 4 are be VBP cord-005453-4057qib7 14138 5 needed need VBN cord-005453-4057qib7 14138 6 to to TO cord-005453-4057qib7 14138 7 assess assess VB cord-005453-4057qib7 14138 8 the the DT cord-005453-4057qib7 14138 9 exposure exposure NN cord-005453-4057qib7 14138 10 dependent dependent JJ cord-005453-4057qib7 14138 11 risks risk NNS cord-005453-4057qib7 14138 12 of of IN cord-005453-4057qib7 14138 13 toxicity toxicity NN cord-005453-4057qib7 14138 14 versus versus IN cord-005453-4057qib7 14138 15 relapse relapse NN cord-005453-4057qib7 14138 16 in in IN cord-005453-4057qib7 14138 17 infants infant NNS cord-005453-4057qib7 14138 18 and and CC cord-005453-4057qib7 14138 19 toddlers toddler NNS cord-005453-4057qib7 14138 20 . . . cord-005453-4057qib7 14139 1 Disclosure disclosure NN cord-005453-4057qib7 14139 2 : : : cord-005453-4057qib7 14139 3 Nothing nothing NN cord-005453-4057qib7 14139 4 to to TO cord-005453-4057qib7 14139 5 declare declare VB cord-005453-4057qib7 14139 6 blood blood NN cord-005453-4057qib7 14139 7 ( ( -LRB- cord-005453-4057qib7 14139 8 UCB UCB NNP cord-005453-4057qib7 14139 9 ) ) -RRB- cord-005453-4057qib7 14139 10 obtained obtain VBD cord-005453-4057qib7 14139 11 at at IN cord-005453-4057qib7 14139 12 delivery delivery NN cord-005453-4057qib7 14139 13 from from IN cord-005453-4057qib7 14139 14 three three CD cord-005453-4057qib7 14139 15 children child NNS cord-005453-4057qib7 14139 16 who who WP cord-005453-4057qib7 14139 17 received receive VBD cord-005453-4057qib7 14139 18 a a DT cord-005453-4057qib7 14139 19 diagnosis diagnosis NN cord-005453-4057qib7 14139 20 of of IN cord-005453-4057qib7 14139 21 cerebral cerebral JJ cord-005453-4057qib7 14139 22 palsy palsy NN cord-005453-4057qib7 14139 23 . . . cord-005453-4057qib7 14140 1 Methods method NNS cord-005453-4057qib7 14140 2 : : : cord-005453-4057qib7 14140 3 Immunophenotyping Immunophenotyping NNP cord-005453-4057qib7 14140 4 of of IN cord-005453-4057qib7 14140 5 the the DT cord-005453-4057qib7 14140 6 UCB UCB NNP cord-005453-4057qib7 14140 7 leukocyte leukocyte NN cord-005453-4057qib7 14140 8 fraction fraction NN cord-005453-4057qib7 14140 9 was be VBD cord-005453-4057qib7 14140 10 performed perform VBN cord-005453-4057qib7 14140 11 using use VBG cord-005453-4057qib7 14140 12 multicolor multicolor JJ cord-005453-4057qib7 14140 13 flow flow NN cord-005453-4057qib7 14140 14 cytometry cytometry NN cord-005453-4057qib7 14140 15 . . . cord-005453-4057qib7 14141 1 The the DT cord-005453-4057qib7 14141 2 procedure procedure NN cord-005453-4057qib7 14141 3 was be VBD cord-005453-4057qib7 14141 4 performed perform VBN cord-005453-4057qib7 14141 5 according accord VBG cord-005453-4057qib7 14141 6 to to IN cord-005453-4057qib7 14141 7 the the DT cord-005453-4057qib7 14141 8 protocol protocol NN cord-005453-4057qib7 14141 9 by by IN cord-005453-4057qib7 14141 10 Shatorje Shatorje NNP cord-005453-4057qib7 14141 11 and and CC cord-005453-4057qib7 14141 12 colleagues colleague NNS cord-005453-4057qib7 14141 13 ( ( -LRB- cord-005453-4057qib7 14141 14 1 1 CD cord-005453-4057qib7 14141 15 ) ) -RRB- cord-005453-4057qib7 14141 16 . . . cord-005453-4057qib7 14142 1 Briefly briefly RB cord-005453-4057qib7 14142 2 , , , cord-005453-4057qib7 14142 3 the the DT cord-005453-4057qib7 14142 4 UCB UCB NNP cord-005453-4057qib7 14142 5 samples sample NNS cord-005453-4057qib7 14142 6 were be VBD cord-005453-4057qib7 14142 7 labeled label VBN cord-005453-4057qib7 14142 8 with with IN cord-005453-4057qib7 14142 9 specific specific JJ cord-005453-4057qib7 14142 10 antibodies antibody NNS cord-005453-4057qib7 14142 11 and and CC cord-005453-4057qib7 14142 12 incubated incubate VBN cord-005453-4057qib7 14142 13 in in IN cord-005453-4057qib7 14142 14 the the DT cord-005453-4057qib7 14142 15 dark dark NN cord-005453-4057qib7 14142 16 for for IN cord-005453-4057qib7 14142 17 30 30 CD cord-005453-4057qib7 14142 18 minutes minute NNS cord-005453-4057qib7 14142 19 . . . cord-005453-4057qib7 14143 1 Afterwards afterwards RB cord-005453-4057qib7 14143 2 , , , cord-005453-4057qib7 14143 3 the the DT cord-005453-4057qib7 14143 4 samples sample NNS cord-005453-4057qib7 14143 5 were be VBD cord-005453-4057qib7 14143 6 treated treat VBN cord-005453-4057qib7 14143 7 with with IN cord-005453-4057qib7 14143 8 5ml 5ml CD cord-005453-4057qib7 14143 9 of of IN cord-005453-4057qib7 14143 10 BD BD NNP cord-005453-4057qib7 14143 11 FACS FACS NNP cord-005453-4057qib7 14143 12 Lysing Lysing NNP cord-005453-4057qib7 14143 13 Solution Solution NNP cord-005453-4057qib7 14143 14 for for IN cord-005453-4057qib7 14143 15 10 10 CD cord-005453-4057qib7 14143 16 minutes minute NNS cord-005453-4057qib7 14143 17 to to TO cord-005453-4057qib7 14143 18 preserve preserve VB cord-005453-4057qib7 14143 19 the the DT cord-005453-4057qib7 14143 20 leukocyte leukocyte NN cord-005453-4057qib7 14143 21 fraction fraction NN cord-005453-4057qib7 14143 22 only only RB cord-005453-4057qib7 14143 23 . . . cord-005453-4057qib7 14144 1 The the DT cord-005453-4057qib7 14144 2 cells cell NNS cord-005453-4057qib7 14144 3 were be VBD cord-005453-4057qib7 14144 4 washed wash VBN cord-005453-4057qib7 14144 5 using use VBG cord-005453-4057qib7 14144 6 PBS PBS NNP cord-005453-4057qib7 14144 7 ( ( -LRB- cord-005453-4057qib7 14144 8 Roche Roche NNP cord-005453-4057qib7 14144 9 ) ) -RRB- cord-005453-4057qib7 14144 10 and and CC cord-005453-4057qib7 14144 11 then then RB cord-005453-4057qib7 14144 12 centrifuged centrifuge VBN cord-005453-4057qib7 14144 13 twice twice RB cord-005453-4057qib7 14144 14 ( ( -LRB- cord-005453-4057qib7 14144 15 1500 1500 CD cord-005453-4057qib7 14144 16 RPM rpm NN cord-005453-4057qib7 14144 17 , , , cord-005453-4057qib7 14144 18 4 4 CD cord-005453-4057qib7 14144 19 ° ° NN cord-005453-4057qib7 14144 20 C c NN cord-005453-4057qib7 14144 21 , , , cord-005453-4057qib7 14144 22 4 4 CD cord-005453-4057qib7 14144 23 minutes minute NNS cord-005453-4057qib7 14144 24 ) ) -RRB- cord-005453-4057qib7 14144 25 . . . cord-005453-4057qib7 14145 1 The the DT cord-005453-4057qib7 14145 2 results result NNS cord-005453-4057qib7 14145 3 were be VBD cord-005453-4057qib7 14145 4 analyzed analyze VBN cord-005453-4057qib7 14145 5 using use VBG cord-005453-4057qib7 14145 6 the the DT cord-005453-4057qib7 14145 7 FACSDiva facsdiva NN cord-005453-4057qib7 14145 8 software software NN cord-005453-4057qib7 14145 9 ( ( -LRB- cord-005453-4057qib7 14145 10 Becton Becton NNP cord-005453-4057qib7 14145 11 Dickinson Dickinson NNP cord-005453-4057qib7 14145 12 ) ) -RRB- cord-005453-4057qib7 14145 13 . . . cord-005453-4057qib7 14146 1 Results result NNS cord-005453-4057qib7 14146 2 : : : cord-005453-4057qib7 14147 1 We -PRON- PRP cord-005453-4057qib7 14147 2 found find VBD cord-005453-4057qib7 14147 3 an an DT cord-005453-4057qib7 14147 4 increased increase VBN cord-005453-4057qib7 14147 5 white white JJ cord-005453-4057qib7 14147 6 blood blood NN cord-005453-4057qib7 14147 7 cell cell NN cord-005453-4057qib7 14147 8 ( ( -LRB- cord-005453-4057qib7 14147 9 WBC WBC NNP cord-005453-4057qib7 14147 10 ) ) -RRB- cord-005453-4057qib7 14147 11 count count NN cord-005453-4057qib7 14147 12 , , , cord-005453-4057qib7 14147 13 lymphocyte lymphocyte NN cord-005453-4057qib7 14147 14 count count NN cord-005453-4057qib7 14147 15 , , , cord-005453-4057qib7 14147 16 and and CC cord-005453-4057qib7 14147 17 CD4 CD4 NNP cord-005453-4057qib7 14147 18 : : : cord-005453-4057qib7 14148 1 CD8 CD8 NNP cord-005453-4057qib7 14148 2 ratio ratio NN cord-005453-4057qib7 14148 3 in in IN cord-005453-4057qib7 14148 4 all all DT cord-005453-4057qib7 14148 5 UCB UCB NNP cord-005453-4057qib7 14148 6 samples sample NNS cord-005453-4057qib7 14148 7 . . . cord-005453-4057qib7 14149 1 One one CD cord-005453-4057qib7 14149 2 patient patient NN cord-005453-4057qib7 14149 3 had have VBD cord-005453-4057qib7 14149 4 a a DT cord-005453-4057qib7 14149 5 low low JJ cord-005453-4057qib7 14149 6 NK NK NNP cord-005453-4057qib7 14149 7 cell cell NN cord-005453-4057qib7 14149 8 count count NN cord-005453-4057qib7 14149 9 and and CC cord-005453-4057qib7 14149 10 percentage percentage NN cord-005453-4057qib7 14149 11 , , , cord-005453-4057qib7 14149 12 and and CC cord-005453-4057qib7 14149 13 another another DT cord-005453-4057qib7 14149 14 had have VBD cord-005453-4057qib7 14149 15 a a DT cord-005453-4057qib7 14149 16 low low JJ cord-005453-4057qib7 14149 17 B b NN cord-005453-4057qib7 14149 18 - - HYPH cord-005453-4057qib7 14149 19 cell cell NN cord-005453-4057qib7 14149 20 count count NN cord-005453-4057qib7 14149 21 and and CC cord-005453-4057qib7 14149 22 percentage percentage NN cord-005453-4057qib7 14149 23 . . . cord-005453-4057qib7 14150 1 One one CD cord-005453-4057qib7 14150 2 sample sample NN cord-005453-4057qib7 14150 3 displayed display VBD cord-005453-4057qib7 14150 4 high high JJ cord-005453-4057qib7 14150 5 T T NNP cord-005453-4057qib7 14150 6 ( ( -LRB- cord-005453-4057qib7 14150 7 CD3 CD3 NNP cord-005453-4057qib7 14150 8 + + SYM cord-005453-4057qib7 14150 9 ) ) -RRB- cord-005453-4057qib7 14150 10 and and CC cord-005453-4057qib7 14150 11 Th Th NNP cord-005453-4057qib7 14150 12 cell cell NN cord-005453-4057qib7 14150 13 ( ( -LRB- cord-005453-4057qib7 14150 14 CD4 CD4 NNP cord-005453-4057qib7 14150 15 + + CC cord-005453-4057qib7 14150 16 ) ) -RRB- cord-005453-4057qib7 14150 17 counts count VBZ cord-005453-4057qib7 14150 18 , , , cord-005453-4057qib7 14150 19 but but CC cord-005453-4057qib7 14150 20 with with IN cord-005453-4057qib7 14150 21 percentages percentage NNS cord-005453-4057qib7 14150 22 within within IN cord-005453-4057qib7 14150 23 the the DT cord-005453-4057qib7 14150 24 limits limit NNS cord-005453-4057qib7 14150 25 of of IN cord-005453-4057qib7 14150 26 the the DT cord-005453-4057qib7 14150 27 reference reference NN cord-005453-4057qib7 14150 28 values value NNS cord-005453-4057qib7 14150 29 . . . cord-005453-4057qib7 14151 1 Conclusions conclusion NNS cord-005453-4057qib7 14151 2 : : : cord-005453-4057qib7 14152 1 We -PRON- PRP cord-005453-4057qib7 14152 2 detected detect VBD cord-005453-4057qib7 14152 3 elevated elevate VBN cord-005453-4057qib7 14152 4 WBC WBC NNP cord-005453-4057qib7 14152 5 and and CC cord-005453-4057qib7 14152 6 lymphocyte lymphocyte NN cord-005453-4057qib7 14152 7 counts count NNS cord-005453-4057qib7 14152 8 in in IN cord-005453-4057qib7 14152 9 all all DT cord-005453-4057qib7 14152 10 UCB UCB NNP cord-005453-4057qib7 14152 11 samples sample NNS cord-005453-4057qib7 14152 12 , , , cord-005453-4057qib7 14152 13 despite despite IN cord-005453-4057qib7 14152 14 a a DT cord-005453-4057qib7 14152 15 lack lack NN cord-005453-4057qib7 14152 16 of of IN cord-005453-4057qib7 14152 17 intrauterine intrauterine JJ cord-005453-4057qib7 14152 18 infection infection NN cord-005453-4057qib7 14152 19 symptoms symptom NNS cord-005453-4057qib7 14152 20 . . . cord-005453-4057qib7 14153 1 Many many JJ cord-005453-4057qib7 14153 2 authors author NNS cord-005453-4057qib7 14153 3 have have VBP cord-005453-4057qib7 14153 4 described describe VBN cord-005453-4057qib7 14153 5 the the DT cord-005453-4057qib7 14153 6 pathogenesis pathogenesis NN cord-005453-4057qib7 14153 7 of of IN cord-005453-4057qib7 14153 8 hypoxic hypoxic JJ cord-005453-4057qib7 14153 9 - - HYPH cord-005453-4057qib7 14153 10 ischemic ischemic JJ cord-005453-4057qib7 14153 11 encephalopathy encephalopathy NN cord-005453-4057qib7 14153 12 . . . cord-005453-4057qib7 14154 1 Briefly briefly RB cord-005453-4057qib7 14154 2 , , , cord-005453-4057qib7 14154 3 after after IN cord-005453-4057qib7 14154 4 an an DT cord-005453-4057qib7 14154 5 acute acute JJ cord-005453-4057qib7 14154 6 hypoxia hypoxia NN cord-005453-4057qib7 14154 7 - - HYPH cord-005453-4057qib7 14154 8 ischemia ischemia NN cord-005453-4057qib7 14154 9 insult insult NN cord-005453-4057qib7 14154 10 , , , cord-005453-4057qib7 14154 11 activated activate VBN cord-005453-4057qib7 14154 12 resting rest VBG cord-005453-4057qib7 14154 13 microglia microglia NNP cord-005453-4057qib7 14154 14 show show VBP cord-005453-4057qib7 14154 15 macrophage macrophage NN cord-005453-4057qib7 14154 16 - - HYPH cord-005453-4057qib7 14154 17 like like JJ cord-005453-4057qib7 14154 18 activity activity NN cord-005453-4057qib7 14154 19 . . . cord-005453-4057qib7 14155 1 This this DT cord-005453-4057qib7 14155 2 leads lead VBZ cord-005453-4057qib7 14155 3 to to IN cord-005453-4057qib7 14155 4 a a DT cord-005453-4057qib7 14155 5 break break NN cord-005453-4057qib7 14155 6 - - HYPH cord-005453-4057qib7 14155 7 down down NN cord-005453-4057qib7 14155 8 of of IN cord-005453-4057qib7 14155 9 the the DT cord-005453-4057qib7 14155 10 blood blood NN cord-005453-4057qib7 14155 11 - - HYPH cord-005453-4057qib7 14155 12 brain brain NN cord-005453-4057qib7 14155 13 barrier barrier NN cord-005453-4057qib7 14155 14 , , , cord-005453-4057qib7 14155 15 infiltration infiltration NN cord-005453-4057qib7 14155 16 by by IN cord-005453-4057qib7 14155 17 peripheral peripheral JJ cord-005453-4057qib7 14155 18 leukocytes leukocyte NNS cord-005453-4057qib7 14155 19 , , , cord-005453-4057qib7 14155 20 and and CC cord-005453-4057qib7 14155 21 brain brain NN cord-005453-4057qib7 14155 22 exposure exposure NN cord-005453-4057qib7 14155 23 , , , cord-005453-4057qib7 14155 24 which which WDT cord-005453-4057qib7 14155 25 further further RB cord-005453-4057qib7 14155 26 exacerbates exacerbate VBZ cord-005453-4057qib7 14155 27 inflammation inflammation NN cord-005453-4057qib7 14155 28 . . . cord-005453-4057qib7 14156 1 The the DT cord-005453-4057qib7 14156 2 role role NN cord-005453-4057qib7 14156 3 of of IN cord-005453-4057qib7 14156 4 systemic systemic JJ cord-005453-4057qib7 14156 5 inflammation inflammation NN cord-005453-4057qib7 14156 6 is be VBZ cord-005453-4057qib7 14156 7 being be VBG cord-005453-4057qib7 14156 8 evaluated evaluate VBN cord-005453-4057qib7 14156 9 in in IN cord-005453-4057qib7 14156 10 the the DT cord-005453-4057qib7 14156 11 animal animal NN cord-005453-4057qib7 14156 12 model model NN cord-005453-4057qib7 14156 13 . . . cord-005453-4057qib7 14157 1 It -PRON- PRP cord-005453-4057qib7 14157 2 is be VBZ cord-005453-4057qib7 14157 3 known know VBN cord-005453-4057qib7 14157 4 that that IN cord-005453-4057qib7 14157 5 systemic systemic JJ cord-005453-4057qib7 14157 6 inflammation inflammation NN cord-005453-4057qib7 14157 7 plays play VBZ cord-005453-4057qib7 14157 8 a a DT cord-005453-4057qib7 14157 9 role role NN cord-005453-4057qib7 14157 10 in in IN cord-005453-4057qib7 14157 11 traumatic traumatic JJ cord-005453-4057qib7 14157 12 brain brain NN cord-005453-4057qib7 14157 13 injury injury NN cord-005453-4057qib7 14157 14 ( ( -LRB- cord-005453-4057qib7 14157 15 TBI TBI NNP cord-005453-4057qib7 14157 16 ) ) -RRB- cord-005453-4057qib7 14157 17 and and CC cord-005453-4057qib7 14157 18 is be VBZ cord-005453-4057qib7 14157 19 an an DT cord-005453-4057qib7 14157 20 independent independent JJ cord-005453-4057qib7 14157 21 risk risk NN cord-005453-4057qib7 14157 22 factor factor NN cord-005453-4057qib7 14157 23 for for IN cord-005453-4057qib7 14157 24 poor poor JJ cord-005453-4057qib7 14157 25 outcome outcome NN cord-005453-4057qib7 14157 26 in in IN cord-005453-4057qib7 14157 27 isolated isolate VBN cord-005453-4057qib7 14157 28 TBI TBI NNP cord-005453-4057qib7 14157 29 patients patient NNS cord-005453-4057qib7 14157 30 . . . cord-005453-4057qib7 14158 1 On on IN cord-005453-4057qib7 14158 2 the the DT cord-005453-4057qib7 14158 3 other other JJ cord-005453-4057qib7 14158 4 hand hand NN cord-005453-4057qib7 14158 5 , , , cord-005453-4057qib7 14158 6 M2-phenotype M2-phenotype NNP cord-005453-4057qib7 14158 7 microglia microglia NNS cord-005453-4057qib7 14158 8 inhibit inhibit VBP cord-005453-4057qib7 14158 9 inflammation inflammation NN cord-005453-4057qib7 14158 10 and and CC cord-005453-4057qib7 14158 11 protect protect VB cord-005453-4057qib7 14158 12 neurons neuron NNS cord-005453-4057qib7 14158 13 from from IN cord-005453-4057qib7 14158 14 secondary secondary JJ cord-005453-4057qib7 14158 15 damage damage NN cord-005453-4057qib7 14158 16 and and CC cord-005453-4057qib7 14158 17 death death NN cord-005453-4057qib7 14158 18 . . . cord-005453-4057qib7 14159 1 However however RB cord-005453-4057qib7 14159 2 , , , cord-005453-4057qib7 14159 3 anti anti JJ cord-005453-4057qib7 14159 4 - - JJ cord-005453-4057qib7 14159 5 inflammatory inflammatory JJ cord-005453-4057qib7 14159 6 mechanisms mechanism NNS cord-005453-4057qib7 14159 7 in in IN cord-005453-4057qib7 14159 8 neonates neonate NNS cord-005453-4057qib7 14159 9 are be VBP cord-005453-4057qib7 14159 10 immature immature JJ cord-005453-4057qib7 14159 11 and and CC cord-005453-4057qib7 14159 12 expose expose VB cord-005453-4057qib7 14159 13 them -PRON- PRP cord-005453-4057qib7 14159 14 to to IN cord-005453-4057qib7 14159 15 extremely extremely RB cord-005453-4057qib7 14159 16 intensive intensive JJ cord-005453-4057qib7 14159 17 inflammation inflammation NN cord-005453-4057qib7 14159 18 . . . cord-005453-4057qib7 14160 1 Therefore therefore RB cord-005453-4057qib7 14160 2 , , , cord-005453-4057qib7 14160 3 anti anti JJ cord-005453-4057qib7 14160 4 - - JJ cord-005453-4057qib7 14160 5 inflammatory inflammatory JJ cord-005453-4057qib7 14160 6 agents agent NNS cord-005453-4057qib7 14160 7 , , , cord-005453-4057qib7 14160 8 including include VBG cord-005453-4057qib7 14160 9 stem stem NN cord-005453-4057qib7 14160 10 cells cell NNS cord-005453-4057qib7 14160 11 , , , cord-005453-4057qib7 14160 12 may may MD cord-005453-4057qib7 14160 13 be be VB cord-005453-4057qib7 14160 14 beneficial beneficial JJ cord-005453-4057qib7 14160 15 in in IN cord-005453-4057qib7 14160 16 these these DT cord-005453-4057qib7 14160 17 patients patient NNS cord-005453-4057qib7 14160 18 . . . cord-005453-4057qib7 14161 1 Disclosure disclosure NN cord-005453-4057qib7 14161 2 : : : cord-005453-4057qib7 14162 1 Three three CD cord-005453-4057qib7 14162 2 of of IN cord-005453-4057qib7 14162 3 four four CD cord-005453-4057qib7 14162 4 authors author NNS cord-005453-4057qib7 14162 5 are be VBP cord-005453-4057qib7 14162 6 employees employee NNS cord-005453-4057qib7 14162 7 of of IN cord-005453-4057qib7 14162 8 the the DT cord-005453-4057qib7 14162 9 Polish Polish NNP cord-005453-4057qib7 14162 10 Stem Stem NNP cord-005453-4057qib7 14162 11 Cell Cell NNP cord-005453-4057qib7 14162 12 Bank Bank NNP cord-005453-4057qib7 14162 13 , , , cord-005453-4057qib7 14162 14 Warsaw Warsaw NNP cord-005453-4057qib7 14162 15 , , , cord-005453-4057qib7 14162 16 Poland Poland NNP cord-005453-4057qib7 14162 17 Reference Reference NNP cord-005453-4057qib7 14162 18 : : : cord-005453-4057qib7 14163 1 Background background NN cord-005453-4057qib7 14163 2 : : : cord-005453-4057qib7 14164 1 Under under IN cord-005453-4057qib7 14164 2 the the DT cord-005453-4057qib7 14164 3 hypothesis hypothesis NN cord-005453-4057qib7 14164 4 that that IN cord-005453-4057qib7 14164 5 early early JJ cord-005453-4057qib7 14164 6 natural natural JJ cord-005453-4057qib7 14164 7 killer killer NN cord-005453-4057qib7 14164 8 cell cell NN cord-005453-4057qib7 14164 9 infusion infusion NN cord-005453-4057qib7 14164 10 ( ( -LRB- cord-005453-4057qib7 14164 11 NKI NKI NNP cord-005453-4057qib7 14164 12 ) ) -RRB- cord-005453-4057qib7 14164 13 following follow VBG cord-005453-4057qib7 14164 14 haploidentical haploidentical JJ cord-005453-4057qib7 14164 15 stem stem NN cord-005453-4057qib7 14164 16 cell cell NN cord-005453-4057qib7 14164 17 transplantation transplantation NN cord-005453-4057qib7 14164 18 ( ( -LRB- cord-005453-4057qib7 14164 19 haplo haplo NNP cord-005453-4057qib7 14164 20 - - HYPH cord-005453-4057qib7 14164 21 SCT SCT NNP cord-005453-4057qib7 14164 22 ) ) -RRB- cord-005453-4057qib7 14164 23 will will MD cord-005453-4057qib7 14164 24 reduce reduce VB cord-005453-4057qib7 14164 25 relapse relapse NN cord-005453-4057qib7 14164 26 in in IN cord-005453-4057qib7 14164 27 the the DT cord-005453-4057qib7 14164 28 early early JJ cord-005453-4057qib7 14164 29 post post JJ cord-005453-4057qib7 14164 30 - - JJ cord-005453-4057qib7 14164 31 transplant transplant JJ cord-005453-4057qib7 14164 32 period period NN cord-005453-4057qib7 14164 33 , , , cord-005453-4057qib7 14164 34 we -PRON- PRP cord-005453-4057qib7 14164 35 conducted conduct VBD cord-005453-4057qib7 14164 36 a a DT cord-005453-4057qib7 14164 37 pilot pilot NN cord-005453-4057qib7 14164 38 study study NN cord-005453-4057qib7 14164 39 to to TO cord-005453-4057qib7 14164 40 evaluate evaluate VB cord-005453-4057qib7 14164 41 the the DT cord-005453-4057qib7 14164 42 safety safety NN cord-005453-4057qib7 14164 43 and and CC cord-005453-4057qib7 14164 44 feasibility feasibility NN cord-005453-4057qib7 14164 45 of of IN cord-005453-4057qib7 14164 46 NKI NKI NNP cord-005453-4057qib7 14164 47 following follow VBG cord-005453-4057qib7 14164 48 haplo haplo NNP cord-005453-4057qib7 14164 49 - - HYPH cord-005453-4057qib7 14164 50 SCT SCT NNP cord-005453-4057qib7 14164 51 in in IN cord-005453-4057qib7 14164 52 children child NNS cord-005453-4057qib7 14164 53 with with IN cord-005453-4057qib7 14164 54 recurrent recurrent JJ cord-005453-4057qib7 14164 55 neuroblastoma neuroblastoma NN cord-005453-4057qib7 14164 56 who who WP cord-005453-4057qib7 14164 57 failed fail VBD cord-005453-4057qib7 14164 58 previous previous JJ cord-005453-4057qib7 14164 59 tandem tandem JJ cord-005453-4057qib7 14164 60 high high JJ cord-005453-4057qib7 14164 61 - - HYPH cord-005453-4057qib7 14164 62 dose dose NN cord-005453-4057qib7 14164 63 chemotherapy chemotherapy NN cord-005453-4057qib7 14164 64 and and CC cord-005453-4057qib7 14164 65 autologous autologous JJ cord-005453-4057qib7 14164 66 SCT SCT NNP cord-005453-4057qib7 14164 67 . . . cord-005453-4057qib7 14165 1 Methods method NNS cord-005453-4057qib7 14165 2 : : : cord-005453-4057qib7 14166 1 We -PRON- PRP cord-005453-4057qib7 14166 2 used use VBD cord-005453-4057qib7 14166 3 the the DT cord-005453-4057qib7 14166 4 high high JJ cord-005453-4057qib7 14166 5 - - HYPH cord-005453-4057qib7 14166 6 dose dose NN cord-005453-4057qib7 14166 7 131 131 CD cord-005453-4057qib7 14166 8 I I NNP cord-005453-4057qib7 14166 9 - - HYPH cord-005453-4057qib7 14166 10 metaiodo metaiodo JJ cord-005453-4057qib7 14166 11 benzylguanidine benzylguanidine NN cord-005453-4057qib7 14166 12 and and CC cord-005453-4057qib7 14166 13 cyclophosphamide cyclophosphamide NNP cord-005453-4057qib7 14166 14 / / SYM cord-005453-4057qib7 14166 15 fludarabine fludarabine NNP cord-005453-4057qib7 14166 16 / / SYM cord-005453-4057qib7 14166 17 antithymocyte antithymocyte NNP cord-005453-4057qib7 14166 18 globulin globulin NN cord-005453-4057qib7 14166 19 regimen regimen NN cord-005453-4057qib7 14166 20 for for IN cord-005453-4057qib7 14166 21 conditioning conditioning NN cord-005453-4057qib7 14166 22 and and CC cord-005453-4057qib7 14166 23 infused infuse VBD cord-005453-4057qib7 14166 24 3×10 3×10 CD cord-005453-4057qib7 14166 25 7 7 CD cord-005453-4057qib7 14166 26 /kg /kg NN cord-005453-4057qib7 14166 27 of of IN cord-005453-4057qib7 14166 28 ex ex NN cord-005453-4057qib7 14166 29 - - NN cord-005453-4057qib7 14166 30 vivo vivo JJ cord-005453-4057qib7 14166 31 expanded expand VBN cord-005453-4057qib7 14166 32 NK NK NNP cord-005453-4057qib7 14166 33 cells cell NNS cord-005453-4057qib7 14166 34 derived derive VBN cord-005453-4057qib7 14166 35 from from IN cord-005453-4057qib7 14166 36 a a DT cord-005453-4057qib7 14166 37 haploidentical haploidentical JJ cord-005453-4057qib7 14166 38 parent parent NN cord-005453-4057qib7 14166 39 donor donor NN cord-005453-4057qib7 14166 40 on on IN cord-005453-4057qib7 14166 41 days day NNS cord-005453-4057qib7 14166 42 2 2 CD cord-005453-4057qib7 14166 43 , , , cord-005453-4057qib7 14166 44 9 9 CD cord-005453-4057qib7 14166 45 , , , cord-005453-4057qib7 14166 46 and and CC cord-005453-4057qib7 14166 47 16 16 CD cord-005453-4057qib7 14166 48 posttransplant posttransplant NN cord-005453-4057qib7 14166 49 . . . cord-005453-4057qib7 14167 1 Results result NNS cord-005453-4057qib7 14167 2 : : : cord-005453-4057qib7 14168 1 Seven seven CD cord-005453-4057qib7 14168 2 children child NNS cord-005453-4057qib7 14168 3 received receive VBD cord-005453-4057qib7 14168 4 a a DT cord-005453-4057qib7 14168 5 total total NN cord-005453-4057qib7 14168 6 of of IN cord-005453-4057qib7 14168 7 19 19 CD cord-005453-4057qib7 14168 8 NKIs nki NNS cord-005453-4057qib7 14168 9 , , , cord-005453-4057qib7 14168 10 and and CC cord-005453-4057qib7 14168 11 NKI NKI NNP cord-005453-4057qib7 14168 12 - - HYPH cord-005453-4057qib7 14168 13 related relate VBN cord-005453-4057qib7 14168 14 acute acute JJ cord-005453-4057qib7 14168 15 toxicities toxicity NNS cord-005453-4057qib7 14168 16 were be VBD cord-005453-4057qib7 14168 17 fever fever NN cord-005453-4057qib7 14168 18 ( ( -LRB- cord-005453-4057qib7 14168 19 n n NN cord-005453-4057qib7 14168 20 = = SYM cord-005453-4057qib7 14168 21 4 4 CD cord-005453-4057qib7 14168 22 ) ) -RRB- cord-005453-4057qib7 14168 23 followed follow VBN cord-005453-4057qib7 14168 24 by by IN cord-005453-4057qib7 14168 25 chills chill NNS cord-005453-4057qib7 14168 26 ( ( -LRB- cord-005453-4057qib7 14168 27 n n NN cord-005453-4057qib7 14168 28 = = SYM cord-005453-4057qib7 14168 29 3 3 CD cord-005453-4057qib7 14168 30 ) ) -RRB- cord-005453-4057qib7 14168 31 and and CC cord-005453-4057qib7 14168 32 hypertension hypertension NN cord-005453-4057qib7 14168 33 ( ( -LRB- cord-005453-4057qib7 14168 34 n n NN cord-005453-4057qib7 14168 35 = = SYM cord-005453-4057qib7 14168 36 3 3 CD cord-005453-4057qib7 14168 37 ) ) -RRB- cord-005453-4057qib7 14168 38 ; ; : cord-005453-4057qib7 14168 39 all all DT cord-005453-4057qib7 14168 40 toxicities toxicity NNS cord-005453-4057qib7 14168 41 were be VBD cord-005453-4057qib7 14168 42 tolerable tolerable JJ cord-005453-4057qib7 14168 43 . . . cord-005453-4057qib7 14169 1 Grade grade NN cord-005453-4057qib7 14169 2 ≥II ≥II NNP cord-005453-4057qib7 14169 3 acute acute JJ cord-005453-4057qib7 14169 4 GVHD GVHD NNP cord-005453-4057qib7 14169 5 and and CC cord-005453-4057qib7 14169 6 chronic chronic JJ cord-005453-4057qib7 14169 7 GVHD GVHD NNP cord-005453-4057qib7 14169 8 developed develop VBN cord-005453-4057qib7 14169 9 in in IN cord-005453-4057qib7 14169 10 two two CD cord-005453-4057qib7 14169 11 and and CC cord-005453-4057qib7 14169 12 five five CD cord-005453-4057qib7 14169 13 patients patient NNS cord-005453-4057qib7 14169 14 , , , cord-005453-4057qib7 14169 15 respectively respectively RB cord-005453-4057qib7 14169 16 . . . cord-005453-4057qib7 14170 1 Higher high JJR cord-005453-4057qib7 14170 2 amount amount NN cord-005453-4057qib7 14170 3 of of IN cord-005453-4057qib7 14170 4 NK NK NNP cord-005453-4057qib7 14170 5 cell cell NN cord-005453-4057qib7 14170 6 population population NN cord-005453-4057qib7 14170 7 were be VBD cord-005453-4057qib7 14170 8 detected detect VBN cord-005453-4057qib7 14170 9 in in IN cord-005453-4057qib7 14170 10 peripheral peripheral JJ cord-005453-4057qib7 14170 11 blood blood NN cord-005453-4057qib7 14170 12 until until IN cord-005453-4057qib7 14170 13 60 60 CD cord-005453-4057qib7 14170 14 days day NNS cord-005453-4057qib7 14170 15 post post JJ cord-005453-4057qib7 14170 16 - - JJ cord-005453-4057qib7 14170 17 transplant transplant NN cord-005453-4057qib7 14170 18 compared compare VBN cord-005453-4057qib7 14170 19 with with IN cord-005453-4057qib7 14170 20 reference reference NN cord-005453-4057qib7 14170 21 cohort cohort NN cord-005453-4057qib7 14170 22 . . . cord-005453-4057qib7 14171 1 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 14171 2 and and CC cord-005453-4057qib7 14171 3 BK BK NNP cord-005453-4057qib7 14171 4 virus virus NN cord-005453-4057qib7 14171 5 reactivation reactivation NN cord-005453-4057qib7 14171 6 occurred occur VBD cord-005453-4057qib7 14171 7 in in IN cord-005453-4057qib7 14171 8 all all DT cord-005453-4057qib7 14171 9 patients patient NNS cord-005453-4057qib7 14171 10 and and CC cord-005453-4057qib7 14171 11 Epstein Epstein NNP cord-005453-4057qib7 14171 12 - - HYPH cord-005453-4057qib7 14171 13 Barr Barr NNP cord-005453-4057qib7 14171 14 virus virus NN cord-005453-4057qib7 14171 15 in in IN cord-005453-4057qib7 14171 16 six six CD cord-005453-4057qib7 14171 17 patients patient NNS cord-005453-4057qib7 14171 18 . . . cord-005453-4057qib7 14172 1 Six six CD cord-005453-4057qib7 14172 2 patients patient NNS cord-005453-4057qib7 14172 3 died die VBD cord-005453-4057qib7 14172 4 of of IN cord-005453-4057qib7 14172 5 relapse relapse NN cord-005453-4057qib7 14172 6 / / SYM cord-005453-4057qib7 14172 7 progression progression NN cord-005453-4057qib7 14172 8 ( ( -LRB- cord-005453-4057qib7 14172 9 n n NN cord-005453-4057qib7 14172 10 = = SYM cord-005453-4057qib7 14172 11 5 5 CD cord-005453-4057qib7 14172 12 ) ) -RRB- cord-005453-4057qib7 14172 13 or or CC cord-005453-4057qib7 14172 14 treatment treatment NN cord-005453-4057qib7 14172 15 - - HYPH cord-005453-4057qib7 14172 16 related relate VBN cord-005453-4057qib7 14172 17 mortality mortality NN cord-005453-4057qib7 14172 18 ( ( -LRB- cord-005453-4057qib7 14172 19 n n NN cord-005453-4057qib7 14172 20 = = SYM cord-005453-4057qib7 14172 21 1 1 CD cord-005453-4057qib7 14172 22 ) ) -RRB- cord-005453-4057qib7 14172 23 , , , cord-005453-4057qib7 14172 24 and and CC cord-005453-4057qib7 14172 25 one one CD cord-005453-4057qib7 14172 26 patient patient NN cord-005453-4057qib7 14172 27 remained remain VBD cord-005453-4057qib7 14172 28 alive alive JJ cord-005453-4057qib7 14172 29 . . . cord-005453-4057qib7 14173 1 Conclusions conclusion NNS cord-005453-4057qib7 14173 2 : : : cord-005453-4057qib7 14174 1 NKI NKI NNP cord-005453-4057qib7 14174 2 following follow VBG cord-005453-4057qib7 14174 3 haplo haplo NNP cord-005453-4057qib7 14174 4 - - HYPH cord-005453-4057qib7 14174 5 SCT SCT NNP cord-005453-4057qib7 14174 6 was be VBD cord-005453-4057qib7 14174 7 relatively relatively RB cord-005453-4057qib7 14174 8 safe safe JJ cord-005453-4057qib7 14174 9 and and CC cord-005453-4057qib7 14174 10 feasible feasible JJ cord-005453-4057qib7 14174 11 in in IN cord-005453-4057qib7 14174 12 patients patient NNS cord-005453-4057qib7 14174 13 with with IN cord-005453-4057qib7 14174 14 recurrent recurrent JJ cord-005453-4057qib7 14174 15 neuroblastoma neuroblastoma NN cord-005453-4057qib7 14174 16 . . . cord-005453-4057qib7 14175 1 Further further JJ cord-005453-4057qib7 14175 2 studies study NNS cord-005453-4057qib7 14175 3 to to TO cord-005453-4057qib7 14175 4 enhance enhance VB cord-005453-4057qib7 14175 5 the the DT cord-005453-4057qib7 14175 6 graft graft NN cord-005453-4057qib7 14175 7 - - HYPH cord-005453-4057qib7 14175 8 versus versus IN cord-005453-4057qib7 14175 9 - - HYPH cord-005453-4057qib7 14175 10 tumor tumor NN cord-005453-4057qib7 14175 11 effect effect NN cord-005453-4057qib7 14175 12 without without IN cord-005453-4057qib7 14175 13 increasing increase VBG cord-005453-4057qib7 14175 14 GVHD GVHD NNP cord-005453-4057qib7 14175 15 are be VBP cord-005453-4057qib7 14175 16 needed need VBN cord-005453-4057qib7 14175 17 . . . cord-005453-4057qib7 14176 1 Disclosure disclosure NN cord-005453-4057qib7 14176 2 : : : cord-005453-4057qib7 14176 3 Nothing nothing NN cord-005453-4057qib7 14176 4 to to TO cord-005453-4057qib7 14176 5 declare declare VB cord-005453-4057qib7 14176 6 Regenerative regenerative JJ cord-005453-4057qib7 14176 7 medicine medicine NN cord-005453-4057qib7 14176 8 P652 p652 XX cord-005453-4057qib7 14176 9 Repeated repeat VBD cord-005453-4057qib7 14176 10 administration administration NN cord-005453-4057qib7 14176 11 of of IN cord-005453-4057qib7 14176 12 G G NNP cord-005453-4057qib7 14176 13 - - HYPH cord-005453-4057qib7 14176 14 CSF CSF NNP cord-005453-4057qib7 14176 15 using use VBG cord-005453-4057qib7 14176 16 stem stem NN cord-005453-4057qib7 14176 17 cell cell NN cord-005453-4057qib7 14176 18 mobilization mobilization NN cord-005453-4057qib7 14176 19 protocol protocol NN cord-005453-4057qib7 14176 20 could could MD cord-005453-4057qib7 14176 21 induce induce VB cord-005453-4057qib7 14176 22 improvement improvement NN cord-005453-4057qib7 14176 23 of of IN cord-005453-4057qib7 14176 24 cognitive cognitive JJ cord-005453-4057qib7 14176 25 functions function NNS cord-005453-4057qib7 14176 26 of of IN cord-005453-4057qib7 14176 27 children child NNS cord-005453-4057qib7 14176 28 with with IN cord-005453-4057qib7 14176 29 cerebral cerebral JJ cord-005453-4057qib7 14176 30 palsy palsy NN cord-005453-4057qib7 14176 31 : : : cord-005453-4057qib7 14176 32 Phase phase NN cord-005453-4057qib7 14176 33 II ii CD cord-005453-4057qib7 14177 1 randomized randomized JJ cord-005453-4057qib7 14177 2 placebo placebo NN cord-005453-4057qib7 14177 3 - - HYPH cord-005453-4057qib7 14177 4 controlled control VBN cord-005453-4057qib7 14177 5 study study NN cord-005453-4057qib7 14177 6 Background background NN cord-005453-4057qib7 14178 1 : : : cord-005453-4057qib7 14178 2 We -PRON- PRP cord-005453-4057qib7 14178 3 performed perform VBD cord-005453-4057qib7 14178 4 phase phase NN cord-005453-4057qib7 14178 5 II ii CD cord-005453-4057qib7 14178 6 randomized randomized JJ cord-005453-4057qib7 14178 7 placebocontrolled placebocontrolled JJ cord-005453-4057qib7 14178 8 clinical clinical JJ cord-005453-4057qib7 14178 9 study study NN cord-005453-4057qib7 14178 10 to to TO cord-005453-4057qib7 14178 11 reveal reveal VB cord-005453-4057qib7 14178 12 the the DT cord-005453-4057qib7 14178 13 safety safety NN cord-005453-4057qib7 14178 14 and and CC cord-005453-4057qib7 14178 15 feasibility feasibility NN cord-005453-4057qib7 14178 16 of of IN cord-005453-4057qib7 14178 17 repeated repeat VBN cord-005453-4057qib7 14178 18 granulocyte granulocyte NN cord-005453-4057qib7 14178 19 colony colony NN cord-005453-4057qib7 14178 20 - - HYPH cord-005453-4057qib7 14178 21 stimulating stimulate VBG cord-005453-4057qib7 14178 22 factor factor NN cord-005453-4057qib7 14178 23 ( ( -LRB- cord-005453-4057qib7 14178 24 G G NNP cord-005453-4057qib7 14178 25 - - HYPH cord-005453-4057qib7 14178 26 CSF CSF NNP cord-005453-4057qib7 14178 27 ) ) -RRB- cord-005453-4057qib7 14178 28 administration administration NN cord-005453-4057qib7 14178 29 for for IN cord-005453-4057qib7 14178 30 improvement improvement NN cord-005453-4057qib7 14178 31 of of IN cord-005453-4057qib7 14178 32 cognitive cognitive JJ cord-005453-4057qib7 14178 33 functions function NNS cord-005453-4057qib7 14178 34 of of IN cord-005453-4057qib7 14178 35 children child NNS cord-005453-4057qib7 14178 36 with with IN cord-005453-4057qib7 14178 37 cerebral cerebral JJ cord-005453-4057qib7 14178 38 palsy palsy NN cord-005453-4057qib7 14178 39 . . . cord-005453-4057qib7 14179 1 Methods method NNS cord-005453-4057qib7 14179 2 : : : cord-005453-4057qib7 14179 3 Forty forty CD cord-005453-4057qib7 14179 4 - - HYPH cord-005453-4057qib7 14179 5 four four CD cord-005453-4057qib7 14179 6 children child NNS cord-005453-4057qib7 14179 7 with with IN cord-005453-4057qib7 14179 8 non non JJ cord-005453-4057qib7 14179 9 - - JJ cord-005453-4057qib7 14179 10 severe severe JJ cord-005453-4057qib7 14179 11 type type NN cord-005453-4057qib7 14179 12 of of IN cord-005453-4057qib7 14179 13 cerebral cerebral JJ cord-005453-4057qib7 14179 14 palsy palsy NN cord-005453-4057qib7 14179 15 were be VBD cord-005453-4057qib7 14179 16 enrolled enrol VBN cord-005453-4057qib7 14179 17 , , , cord-005453-4057qib7 14179 18 and and CC cord-005453-4057qib7 14179 19 their -PRON- PRP$ cord-005453-4057qib7 14179 20 age age NN cord-005453-4057qib7 14179 21 were be VBD cord-005453-4057qib7 14179 22 2 2 CD cord-005453-4057qib7 14179 23 - - SYM cord-005453-4057qib7 14179 24 10 10 CD cord-005453-4057qib7 14179 25 years year NNS cord-005453-4057qib7 14179 26 old old JJ cord-005453-4057qib7 14179 27 . . . cord-005453-4057qib7 14180 1 G G NNP cord-005453-4057qib7 14180 2 - - HYPH cord-005453-4057qib7 14180 3 CSF CSF NNP cord-005453-4057qib7 14180 4 ( ( -LRB- cord-005453-4057qib7 14180 5 5μg 5μg NNP cord-005453-4057qib7 14180 6 / / SYM cord-005453-4057qib7 14180 7 kg kg NN cord-005453-4057qib7 14180 8 ) ) -RRB- cord-005453-4057qib7 14180 9 was be VBD cord-005453-4057qib7 14180 10 administered administer VBN cord-005453-4057qib7 14180 11 for for IN cord-005453-4057qib7 14180 12 5 5 CD cord-005453-4057qib7 14180 13 days day NNS cord-005453-4057qib7 14180 14 subcutaneously subcutaneously RB cord-005453-4057qib7 14180 15 every every DT cord-005453-4057qib7 14180 16 3months 3months NN cord-005453-4057qib7 14180 17 during during IN cord-005453-4057qib7 14180 18 18 18 CD cord-005453-4057qib7 14180 19 months month NNS cord-005453-4057qib7 14180 20 . . . cord-005453-4057qib7 14181 1 We -PRON- PRP cord-005453-4057qib7 14181 2 compared compare VBD cord-005453-4057qib7 14181 3 their -PRON- PRP$ cord-005453-4057qib7 14181 4 cognitive cognitive JJ cord-005453-4057qib7 14181 5 functions function NNS cord-005453-4057qib7 14181 6 with with IN cord-005453-4057qib7 14181 7 the the DT cord-005453-4057qib7 14181 8 magnetic magnetic JJ cord-005453-4057qib7 14181 9 resonance resonance NN cord-005453-4057qib7 14181 10 imaging imaging NN cord-005453-4057qib7 14181 11 ( ( -LRB- cord-005453-4057qib7 14181 12 MRI MRI NNP cord-005453-4057qib7 14181 13 ) ) -RRB- cord-005453-4057qib7 14181 14 findings finding NNS cord-005453-4057qib7 14181 15 and and CC cord-005453-4057qib7 14181 16 the the DT cord-005453-4057qib7 14181 17 following follow VBG cord-005453-4057qib7 14181 18 tools tool NNS cord-005453-4057qib7 14181 19 between between IN cord-005453-4057qib7 14181 20 before before RB cord-005453-4057qib7 14181 21 and and CC cord-005453-4057qib7 14181 22 18 18 CD cord-005453-4057qib7 14181 23 months month NNS cord-005453-4057qib7 14181 24 after after IN cord-005453-4057qib7 14181 25 treatment treatment NN cord-005453-4057qib7 14181 26 ; ; : cord-005453-4057qib7 14181 27 zoo zoo NN cord-005453-4057qib7 14181 28 location location NN cord-005453-4057qib7 14181 29 and and CC cord-005453-4057qib7 14181 30 picture picture NN cord-005453-4057qib7 14181 31 memory memory NN cord-005453-4057qib7 14181 32 as as IN cord-005453-4057qib7 14181 33 working work VBG cord-005453-4057qib7 14181 34 memory memory NN cord-005453-4057qib7 14181 35 index index NN cord-005453-4057qib7 14181 36 ( ( -LRB- cord-005453-4057qib7 14181 37 WMI WMI NNP cord-005453-4057qib7 14181 38 ) ) -RRB- cord-005453-4057qib7 14181 39 in in IN cord-005453-4057qib7 14181 40 Wechsler Wechsler NNP cord-005453-4057qib7 14181 41 Preschool Preschool NNP cord-005453-4057qib7 14181 42 and and CC cord-005453-4057qib7 14181 43 Primary Primary NNP cord-005453-4057qib7 14181 44 Scale Scale NNP cord-005453-4057qib7 14181 45 of of IN cord-005453-4057qib7 14181 46 Intelligence Intelligence NNP cord-005453-4057qib7 14181 47 ( ( -LRB- cord-005453-4057qib7 14181 48 WPSSI WPSSI NNP cord-005453-4057qib7 14181 49 ) ) -RRB- cord-005453-4057qib7 14181 50 , , , cord-005453-4057qib7 14181 51 receptive receptive JJ cord-005453-4057qib7 14181 52 and and CC cord-005453-4057qib7 14181 53 expressive expressive JJ cord-005453-4057qib7 14181 54 vocabulary vocabulary NN cord-005453-4057qib7 14181 55 test test NN cord-005453-4057qib7 14181 56 ( ( -LRB- cord-005453-4057qib7 14181 57 REVT REVT NNP cord-005453-4057qib7 14181 58 ) ) -RRB- cord-005453-4057qib7 14181 59 , , , cord-005453-4057qib7 14181 60 and and CC cord-005453-4057qib7 14181 61 visual visual JJ cord-005453-4057qib7 14181 62 motor motor NN cord-005453-4057qib7 14181 63 integration integration NN cord-005453-4057qib7 14181 64 ( ( -LRB- cord-005453-4057qib7 14181 65 VMI)/visual vmi)/visual JJ cord-005453-4057qib7 14181 66 perception perception NN cord-005453-4057qib7 14181 67 ( ( -LRB- cord-005453-4057qib7 14181 68 VP VP NNP cord-005453-4057qib7 14181 69 ) ) -RRB- cord-005453-4057qib7 14181 70 test test NN cord-005453-4057qib7 14181 71 . . . cord-005453-4057qib7 14182 1 Mobilized mobilize VBN cord-005453-4057qib7 14182 2 stem stem NN cord-005453-4057qib7 14182 3 cell cell NN cord-005453-4057qib7 14182 4 count count NN cord-005453-4057qib7 14182 5 and and CC cord-005453-4057qib7 14182 6 cytokine cytokine NN cord-005453-4057qib7 14182 7 levels level NNS cord-005453-4057qib7 14182 8 were be VBD cord-005453-4057qib7 14182 9 measured measure VBN cord-005453-4057qib7 14182 10 before before RB cord-005453-4057qib7 14182 11 ( ( -LRB- cord-005453-4057qib7 14182 12 D+0 D+0 NNP cord-005453-4057qib7 14182 13 ) ) -RRB- cord-005453-4057qib7 14182 14 and and CC cord-005453-4057qib7 14182 15 after after IN cord-005453-4057qib7 14182 16 ( ( -LRB- cord-005453-4057qib7 14182 17 D+5 d+5 NN cord-005453-4057qib7 14182 18 ) ) -RRB- cord-005453-4057qib7 14182 19 G G NNP cord-005453-4057qib7 14182 20 - - HYPH cord-005453-4057qib7 14182 21 CSF CSF NNP cord-005453-4057qib7 14182 22 administration administration NN cord-005453-4057qib7 14182 23 for for IN cord-005453-4057qib7 14182 24 5 5 CD cord-005453-4057qib7 14182 25 days day NNS cord-005453-4057qib7 14182 26 every every DT cord-005453-4057qib7 14182 27 3 3 CD cord-005453-4057qib7 14182 28 months month NNS cord-005453-4057qib7 14182 29 . . . cord-005453-4057qib7 14183 1 Results result NNS cord-005453-4057qib7 14183 2 : : : cord-005453-4057qib7 14184 1 No no DT cord-005453-4057qib7 14184 2 significant significant JJ cord-005453-4057qib7 14184 3 findings finding NNS cord-005453-4057qib7 14184 4 in in IN cord-005453-4057qib7 14184 5 demography demography NN cord-005453-4057qib7 14184 6 was be VBD cord-005453-4057qib7 14184 7 noticed notice VBN cord-005453-4057qib7 14184 8 between between IN cord-005453-4057qib7 14184 9 G G NNP cord-005453-4057qib7 14184 10 - - HYPH cord-005453-4057qib7 14184 11 CSF CSF NNP cord-005453-4057qib7 14184 12 ( ( -LRB- cord-005453-4057qib7 14184 13 G- G- NNP cord-005453-4057qib7 14184 14 ) ) -RRB- cord-005453-4057qib7 14184 15 and and CC cord-005453-4057qib7 14184 16 placebo placebo NN cord-005453-4057qib7 14184 17 ( ( -LRB- cord-005453-4057qib7 14184 18 P- P- NNP cord-005453-4057qib7 14184 19 ) ) -RRB- cord-005453-4057qib7 14184 20 groups group NNS cord-005453-4057qib7 14184 21 . . . cord-005453-4057qib7 14185 1 No no DT cord-005453-4057qib7 14185 2 serious serious JJ cord-005453-4057qib7 14185 3 adverse adverse JJ cord-005453-4057qib7 14185 4 events event NNS cord-005453-4057qib7 14185 5 were be VBD cord-005453-4057qib7 14185 6 observed observe VBN cord-005453-4057qib7 14185 7 during during IN cord-005453-4057qib7 14185 8 the the DT cord-005453-4057qib7 14185 9 whole whole JJ cord-005453-4057qib7 14185 10 study study NN cord-005453-4057qib7 14185 11 period period NN cord-005453-4057qib7 14185 12 . . . cord-005453-4057qib7 14186 1 The the DT cord-005453-4057qib7 14186 2 non non JJ cord-005453-4057qib7 14186 3 - - JJ cord-005453-4057qib7 14186 4 severe severe JJ cord-005453-4057qib7 14186 5 adverse adverse JJ cord-005453-4057qib7 14186 6 events event NNS cord-005453-4057qib7 14186 7 such such JJ cord-005453-4057qib7 14186 8 as as IN cord-005453-4057qib7 14186 9 urticaria urticaria NN cord-005453-4057qib7 14186 10 ( ( -LRB- cord-005453-4057qib7 14186 11 n=1 n=1 CD cord-005453-4057qib7 14186 12 ) ) -RRB- cord-005453-4057qib7 14186 13 , , , cord-005453-4057qib7 14186 14 itching itch VBG cord-005453-4057qib7 14186 15 sense sense NN cord-005453-4057qib7 14186 16 ( ( -LRB- cord-005453-4057qib7 14186 17 n=3 n=3 NN cord-005453-4057qib7 14186 18 ) ) -RRB- cord-005453-4057qib7 14186 19 , , , cord-005453-4057qib7 14186 20 bone bone NN cord-005453-4057qib7 14186 21 pain pain NN cord-005453-4057qib7 14186 22 ( ( -LRB- cord-005453-4057qib7 14186 23 n=1 n=1 FW cord-005453-4057qib7 14186 24 ) ) -RRB- cord-005453-4057qib7 14186 25 , , , cord-005453-4057qib7 14186 26 headache headache NN cord-005453-4057qib7 14186 27 ( ( -LRB- cord-005453-4057qib7 14186 28 n=1 n=1 CD cord-005453-4057qib7 14186 29 ) ) -RRB- cord-005453-4057qib7 14186 30 , , , cord-005453-4057qib7 14186 31 fever fever NN cord-005453-4057qib7 14186 32 ( ( -LRB- cord-005453-4057qib7 14186 33 n=2 n=2 NNS cord-005453-4057qib7 14186 34 ) ) -RRB- cord-005453-4057qib7 14186 35 , , , cord-005453-4057qib7 14186 36 and and CC cord-005453-4057qib7 14186 37 stomatitis stomatitis NN cord-005453-4057qib7 14186 38 ( ( -LRB- cord-005453-4057qib7 14186 39 n=1 n=1 FW cord-005453-4057qib7 14186 40 ) ) -RRB- cord-005453-4057qib7 14186 41 were be VBD cord-005453-4057qib7 14186 42 tolerable tolerable JJ cord-005453-4057qib7 14186 43 . . . cord-005453-4057qib7 14187 1 The the DT cord-005453-4057qib7 14187 2 parents parent NNS cord-005453-4057qib7 14187 3 felt feel VBD cord-005453-4057qib7 14187 4 the the DT cord-005453-4057qib7 14187 5 clinical clinical JJ cord-005453-4057qib7 14187 6 improvements improvement NNS cord-005453-4057qib7 14187 7 of of IN cord-005453-4057qib7 14187 8 cognition cognition NN cord-005453-4057qib7 14187 9 in in IN cord-005453-4057qib7 14187 10 10 10 CD cord-005453-4057qib7 14187 11 cases case NNS cord-005453-4057qib7 14187 12 of of IN cord-005453-4057qib7 14187 13 G g NN cord-005453-4057qib7 14187 14 - - HYPH cord-005453-4057qib7 14187 15 group group NN cord-005453-4057qib7 14187 16 and and CC cord-005453-4057qib7 14187 17 4 4 CD cord-005453-4057qib7 14187 18 cases case NNS cord-005453-4057qib7 14187 19 of of IN cord-005453-4057qib7 14187 20 P p NN cord-005453-4057qib7 14187 21 - - HYPH cord-005453-4057qib7 14187 22 group group NN cord-005453-4057qib7 14187 23 ( ( -LRB- cord-005453-4057qib7 14187 24 p=0.0367 p=0.0367 NNP cord-005453-4057qib7 14187 25 ) ) -RRB- cord-005453-4057qib7 14187 26 , , , cord-005453-4057qib7 14187 27 of of IN cord-005453-4057qib7 14187 28 language language NN cord-005453-4057qib7 14187 29 in in IN cord-005453-4057qib7 14187 30 8 8 CD cord-005453-4057qib7 14187 31 cases case NNS cord-005453-4057qib7 14187 32 of of IN cord-005453-4057qib7 14187 33 G g NN cord-005453-4057qib7 14187 34 - - HYPH cord-005453-4057qib7 14187 35 group group NN cord-005453-4057qib7 14187 36 and and CC cord-005453-4057qib7 14187 37 3 3 CD cord-005453-4057qib7 14187 38 cases case NNS cord-005453-4057qib7 14187 39 of of IN cord-005453-4057qib7 14187 40 P p NN cord-005453-4057qib7 14187 41 - - HYPH cord-005453-4057qib7 14187 42 group group NN cord-005453-4057qib7 14187 43 ( ( -LRB- cord-005453-4057qib7 14187 44 p=0.0632 p=0.0632 NNS cord-005453-4057qib7 14187 45 ) ) -RRB- cord-005453-4057qib7 14187 46 . . . cord-005453-4057qib7 14188 1 In in IN cord-005453-4057qib7 14188 2 zoo zoo NN cord-005453-4057qib7 14188 3 location location NN cord-005453-4057qib7 14188 4 test test NN cord-005453-4057qib7 14188 5 , , , cord-005453-4057qib7 14188 6 we -PRON- PRP cord-005453-4057qib7 14188 7 can can MD cord-005453-4057qib7 14188 8 not not RB cord-005453-4057qib7 14188 9 find find VB cord-005453-4057qib7 14188 10 out out RP cord-005453-4057qib7 14188 11 the the DT cord-005453-4057qib7 14188 12 significant significant JJ cord-005453-4057qib7 14188 13 score score NN cord-005453-4057qib7 14188 14 ( ( -LRB- cord-005453-4057qib7 14188 15 expressed express VBN cord-005453-4057qib7 14188 16 as as IN cord-005453-4057qib7 14188 17 age age NN cord-005453-4057qib7 14188 18 equivalent equivalent JJ cord-005453-4057qib7 14188 19 ) ) -RRB- cord-005453-4057qib7 14188 20 differences difference NNS cord-005453-4057qib7 14188 21 between between IN cord-005453-4057qib7 14188 22 G g NN cord-005453-4057qib7 14188 23 - - : cord-005453-4057qib7 14188 24 and and CC cord-005453-4057qib7 14188 25 P p NN cord-005453-4057qib7 14188 26 - - HYPH cord-005453-4057qib7 14188 27 groups group NNS cord-005453-4057qib7 14188 28 . . . cord-005453-4057qib7 14189 1 However however RB cord-005453-4057qib7 14189 2 , , , cord-005453-4057qib7 14189 3 in in IN cord-005453-4057qib7 14189 4 picture picture NN cord-005453-4057qib7 14189 5 memory memory NN cord-005453-4057qib7 14189 6 test test NN cord-005453-4057qib7 14189 7 , , , cord-005453-4057qib7 14189 8 there there EX cord-005453-4057qib7 14189 9 were be VBD cord-005453-4057qib7 14189 10 significant significant JJ cord-005453-4057qib7 14189 11 improvement improvement NN cord-005453-4057qib7 14189 12 of of IN cord-005453-4057qib7 14189 13 age age NN cord-005453-4057qib7 14189 14 equivalent equivalent JJ cord-005453-4057qib7 14189 15 of of IN cord-005453-4057qib7 14189 16 10 10 CD cord-005453-4057qib7 14189 17 months month NNS cord-005453-4057qib7 14190 1 ( ( -LRB- cord-005453-4057qib7 14190 2 45.60±19.66→55.60±23.27 45.60±19.66→55.60±23.27 LS cord-005453-4057qib7 14190 3 ) ) -RRB- cord-005453-4057qib7 14190 4 during during IN cord-005453-4057qib7 14190 5 18 18 CD cord-005453-4057qib7 14190 6 months month NNS cord-005453-4057qib7 14190 7 of of IN cord-005453-4057qib7 14190 8 study study NN cord-005453-4057qib7 14190 9 period period NN cord-005453-4057qib7 14190 10 in in IN cord-005453-4057qib7 14190 11 G g NN cord-005453-4057qib7 14190 12 - - HYPH cord-005453-4057qib7 14190 13 group group NN cord-005453-4057qib7 14190 14 compared compare VBN cord-005453-4057qib7 14190 15 to to IN cord-005453-4057qib7 14190 16 3 3 CD cord-005453-4057qib7 14190 17 months month NNS cord-005453-4057qib7 14190 18 in in IN cord-005453-4057qib7 14190 19 P p NN cord-005453-4057qib7 14190 20 - - HYPH cord-005453-4057qib7 14190 21 group group NN cord-005453-4057qib7 14190 22 ( ( -LRB- cord-005453-4057qib7 14190 23 p=0.0242 p=0.0242 NN cord-005453-4057qib7 14190 24 ) ) -RRB- cord-005453-4057qib7 14190 25 . . . cord-005453-4057qib7 14191 1 In in IN cord-005453-4057qib7 14191 2 REVT REVT NNP cord-005453-4057qib7 14191 3 , , , cord-005453-4057qib7 14191 4 there there EX cord-005453-4057qib7 14191 5 were be VBD cord-005453-4057qib7 14191 6 significant significant JJ cord-005453-4057qib7 14191 7 improvement improvement NN cord-005453-4057qib7 14191 8 of of IN cord-005453-4057qib7 14191 9 18 18 CD cord-005453-4057qib7 14191 10 months month NNS cord-005453-4057qib7 14191 11 of of IN cord-005453-4057qib7 14191 12 age age NN cord-005453-4057qib7 14191 13 equivalent equivalent JJ cord-005453-4057qib7 14191 14 in in IN cord-005453-4057qib7 14191 15 expressive expressive JJ cord-005453-4057qib7 14191 16 tests test NNS cord-005453-4057qib7 14191 17 of of IN cord-005453-4057qib7 14191 18 G g NN cord-005453-4057qib7 14191 19 - - HYPH cord-005453-4057qib7 14191 20 group group NN cord-005453-4057qib7 14191 21 ( ( -LRB- cord-005453-4057qib7 14191 22 57.87±33.66→76.00±43.38 57.87±33.66→76.00±43.38 XX cord-005453-4057qib7 14191 23 , , , cord-005453-4057qib7 14191 24 p=0.0198 p=0.0198 NNP cord-005453-4057qib7 14191 25 ) ) -RRB- cord-005453-4057qib7 14191 26 compared compare VBD cord-005453-4057qib7 14191 27 to to IN cord-005453-4057qib7 14191 28 8 8 CD cord-005453-4057qib7 14191 29 months month NNS cord-005453-4057qib7 14191 30 in in IN cord-005453-4057qib7 14191 31 P p NN cord-005453-4057qib7 14191 32 - - HYPH cord-005453-4057qib7 14191 33 group group NN cord-005453-4057qib7 14191 34 . . . cord-005453-4057qib7 14192 1 No no DT cord-005453-4057qib7 14192 2 significant significant JJ cord-005453-4057qib7 14192 3 findings finding NNS cord-005453-4057qib7 14192 4 were be VBD cord-005453-4057qib7 14192 5 noted note VBN cord-005453-4057qib7 14192 6 in in IN cord-005453-4057qib7 14192 7 receptive receptive JJ cord-005453-4057qib7 14192 8 test test NN cord-005453-4057qib7 14192 9 . . . cord-005453-4057qib7 14193 1 VMI VMI NNP cord-005453-4057qib7 14193 2 test test NN cord-005453-4057qib7 14193 3 showed show VBD cord-005453-4057qib7 14193 4 the the DT cord-005453-4057qib7 14193 5 increasing increase VBG cord-005453-4057qib7 14193 6 tendency tendency NN cord-005453-4057qib7 14193 7 of of IN cord-005453-4057qib7 14193 8 14 14 CD cord-005453-4057qib7 14193 9 months month NNS cord-005453-4057qib7 14193 10 of of IN cord-005453-4057qib7 14193 11 age age NN cord-005453-4057qib7 14193 12 equivalent equivalent JJ cord-005453-4057qib7 14193 13 in in IN cord-005453-4057qib7 14193 14 G g NN cord-005453-4057qib7 14193 15 - - HYPH cord-005453-4057qib7 14193 16 group group NN cord-005453-4057qib7 14193 17 ( ( -LRB- cord-005453-4057qib7 14193 18 47.75±13.22→61.13±17.78 47.75±13.22→61.13±17.78 CD cord-005453-4057qib7 14193 19 , , , cord-005453-4057qib7 14193 20 p=0.0746 p=0.0746 NNP cord-005453-4057qib7 14193 21 ) ) -RRB- cord-005453-4057qib7 14193 22 compared compare VBN cord-005453-4057qib7 14193 23 to to IN cord-005453-4057qib7 14193 24 P p NN cord-005453-4057qib7 14193 25 - - HYPH cord-005453-4057qib7 14193 26 group group NN cord-005453-4057qib7 14193 27 . . . cord-005453-4057qib7 14194 1 The the DT cord-005453-4057qib7 14194 2 increment increment NN cord-005453-4057qib7 14194 3 of of IN cord-005453-4057qib7 14194 4 CD34 CD34 NNP cord-005453-4057qib7 14194 5 + + CC cord-005453-4057qib7 14194 6 cell cell NN cord-005453-4057qib7 14194 7 counts count NNS cord-005453-4057qib7 14194 8 in in IN cord-005453-4057qib7 14194 9 peripheral peripheral JJ cord-005453-4057qib7 14194 10 blood blood NN cord-005453-4057qib7 14194 11 were be VBD cord-005453-4057qib7 14194 12 significant significant JJ cord-005453-4057qib7 14194 13 in in IN cord-005453-4057qib7 14194 14 Ggroup Ggroup NNP cord-005453-4057qib7 14194 15 compared compare VBN cord-005453-4057qib7 14194 16 to to IN cord-005453-4057qib7 14194 17 P p NN cord-005453-4057qib7 14194 18 - - HYPH cord-005453-4057qib7 14194 19 group group NN cord-005453-4057qib7 14194 20 . . . cord-005453-4057qib7 14195 1 The the DT cord-005453-4057qib7 14195 2 changed change VBN cord-005453-4057qib7 14195 3 levels level NNS cord-005453-4057qib7 14195 4 of of IN cord-005453-4057qib7 14195 5 interleukin interleukin NN cord-005453-4057qib7 14195 6 ( ( -LRB- cord-005453-4057qib7 14195 7 IL)-6 IL)-6 NNP cord-005453-4057qib7 14195 8 , , , cord-005453-4057qib7 14195 9 IL-10 IL-10 NNP cord-005453-4057qib7 14195 10 , , , cord-005453-4057qib7 14195 11 vascular vascular JJ cord-005453-4057qib7 14195 12 endothelial endothelial JJ cord-005453-4057qib7 14195 13 growth growth NN cord-005453-4057qib7 14195 14 factor factor NN cord-005453-4057qib7 14195 15 ( ( -LRB- cord-005453-4057qib7 14195 16 VEGF VEGF NNP cord-005453-4057qib7 14195 17 ) ) -RRB- cord-005453-4057qib7 14195 18 as as RB cord-005453-4057qib7 14195 19 well well RB cord-005453-4057qib7 14195 20 as as IN cord-005453-4057qib7 14195 21 G G NNP cord-005453-4057qib7 14195 22 - - HYPH cord-005453-4057qib7 14195 23 CSF CSF NNP cord-005453-4057qib7 14195 24 were be VBD cord-005453-4057qib7 14195 25 noted note VBN cord-005453-4057qib7 14195 26 in in IN cord-005453-4057qib7 14195 27 G g NN cord-005453-4057qib7 14195 28 - - HYPH cord-005453-4057qib7 14195 29 group group NN cord-005453-4057qib7 14195 30 . . . cord-005453-4057qib7 14196 1 We -PRON- PRP cord-005453-4057qib7 14196 2 also also RB cord-005453-4057qib7 14196 3 observed observe VBD cord-005453-4057qib7 14196 4 the the DT cord-005453-4057qib7 14196 5 correlation correlation NN cord-005453-4057qib7 14196 6 of of IN cord-005453-4057qib7 14196 7 cognitive cognitive JJ cord-005453-4057qib7 14196 8 function function NN cord-005453-4057qib7 14196 9 tests test NNS cord-005453-4057qib7 14196 10 and and CC cord-005453-4057qib7 14196 11 white white JJ cord-005453-4057qib7 14196 12 matter matter NN cord-005453-4057qib7 14196 13 connectoms connectom NNS cord-005453-4057qib7 14196 14 of of IN cord-005453-4057qib7 14196 15 several several JJ cord-005453-4057qib7 14196 16 networks network NNS cord-005453-4057qib7 14196 17 using use VBG cord-005453-4057qib7 14196 18 functionally functionally RB cord-005453-4057qib7 14196 19 - - HYPH cord-005453-4057qib7 14196 20 defined define VBN cord-005453-4057qib7 14196 21 white white JJ cord-005453-4057qib7 14196 22 matter matter NN cord-005453-4057qib7 14196 23 atlases atlas NNS cord-005453-4057qib7 14196 24 . . . cord-005453-4057qib7 14197 1 Conclusions conclusion NNS cord-005453-4057qib7 14197 2 : : : cord-005453-4057qib7 14198 1 The the DT cord-005453-4057qib7 14198 2 repeated repeated JJ cord-005453-4057qib7 14198 3 administration administration NN cord-005453-4057qib7 14198 4 of of IN cord-005453-4057qib7 14198 5 G G NNP cord-005453-4057qib7 14198 6 - - HYPH cord-005453-4057qib7 14198 7 CSF CSF NNP cord-005453-4057qib7 14198 8 using use VBG cord-005453-4057qib7 14198 9 stem stem NN cord-005453-4057qib7 14198 10 cell cell NN cord-005453-4057qib7 14198 11 mobilization mobilization NN cord-005453-4057qib7 14198 12 protocol protocol NN cord-005453-4057qib7 14198 13 is be VBZ cord-005453-4057qib7 14198 14 safe safe JJ cord-005453-4057qib7 14198 15 and and CC cord-005453-4057qib7 14198 16 feasible feasible JJ cord-005453-4057qib7 14198 17 to to TO cord-005453-4057qib7 14198 18 improve improve VB cord-005453-4057qib7 14198 19 the the DT cord-005453-4057qib7 14198 20 language language NN cord-005453-4057qib7 14198 21 and and CC cord-005453-4057qib7 14198 22 cognitive cognitive JJ cord-005453-4057qib7 14198 23 functions function NNS cord-005453-4057qib7 14198 24 in in IN cord-005453-4057qib7 14198 25 children child NNS cord-005453-4057qib7 14198 26 with with IN cord-005453-4057qib7 14198 27 cerebral cerebral JJ cord-005453-4057qib7 14198 28 palsy palsy NN cord-005453-4057qib7 14198 29 . . . cord-005453-4057qib7 14199 1 Further further JJ cord-005453-4057qib7 14199 2 studies study NNS cord-005453-4057qib7 14199 3 for for IN cord-005453-4057qib7 14199 4 cellular cellular JJ cord-005453-4057qib7 14199 5 and and CC cord-005453-4057qib7 14199 6 paracrine paracrine JJ cord-005453-4057qib7 14199 7 effect effect NN cord-005453-4057qib7 14199 8 of of IN cord-005453-4057qib7 14199 9 G G NNP cord-005453-4057qib7 14199 10 - - HYPH cord-005453-4057qib7 14199 11 CSF CSF NNP cord-005453-4057qib7 14199 12 and/or and/or CC cord-005453-4057qib7 14199 13 mobilized mobilize VBD cord-005453-4057qib7 14199 14 peripheral peripheral JJ cord-005453-4057qib7 14199 15 blood blood NN cord-005453-4057qib7 14199 16 stem stem NN cord-005453-4057qib7 14199 17 cells cell NNS cord-005453-4057qib7 14199 18 would would MD cord-005453-4057qib7 14199 19 be be VB cord-005453-4057qib7 14199 20 needed need VBN cord-005453-4057qib7 14199 21 . . . cord-005453-4057qib7 14200 1 Background background NN cord-005453-4057qib7 14200 2 : : : cord-005453-4057qib7 14201 1 While while IN cord-005453-4057qib7 14201 2 high high JJ cord-005453-4057qib7 14201 3 - - HYPH cord-005453-4057qib7 14201 4 dose dose NN cord-005453-4057qib7 14201 5 chemotherapy chemotherapy NN cord-005453-4057qib7 14201 6 ( ( -LRB- cord-005453-4057qib7 14201 7 HDCT HDCT NNP cord-005453-4057qib7 14201 8 ) ) -RRB- cord-005453-4057qib7 14201 9 with with IN cord-005453-4057qib7 14201 10 autologous autologous JJ cord-005453-4057qib7 14201 11 hematopoietic hematopoietic JJ cord-005453-4057qib7 14201 12 stem stem NN cord-005453-4057qib7 14201 13 cell cell NN cord-005453-4057qib7 14201 14 transplantation transplantation NN cord-005453-4057qib7 14201 15 ( ( -LRB- cord-005453-4057qib7 14201 16 auto auto NN cord-005453-4057qib7 14201 17 - - HYPH cord-005453-4057qib7 14201 18 HSCT HSCT NNP cord-005453-4057qib7 14201 19 ) ) -RRB- cord-005453-4057qib7 14201 20 is be VBZ cord-005453-4057qib7 14201 21 an an DT cord-005453-4057qib7 14201 22 integral integral JJ cord-005453-4057qib7 14201 23 part part NN cord-005453-4057qib7 14201 24 of of IN cord-005453-4057qib7 14201 25 multimodal multimodal NN cord-005453-4057qib7 14201 26 therapy therapy NN cord-005453-4057qib7 14201 27 for for IN cord-005453-4057qib7 14201 28 highrisk highrisk NNP cord-005453-4057qib7 14201 29 neuroblastoma neuroblastoma NN cord-005453-4057qib7 14201 30 ( ( -LRB- cord-005453-4057qib7 14201 31 HR HR NNP cord-005453-4057qib7 14201 32 NB NB NNP cord-005453-4057qib7 14201 33 ) ) -RRB- cord-005453-4057qib7 14201 34 , , , cord-005453-4057qib7 14201 35 there there EX cord-005453-4057qib7 14201 36 are be VBP cord-005453-4057qib7 14201 37 still still RB cord-005453-4057qib7 14201 38 subgroups subgroup NNS cord-005453-4057qib7 14201 39 , , , cord-005453-4057qib7 14201 40 in in IN cord-005453-4057qib7 14201 41 which which WDT cord-005453-4057qib7 14201 42 the the DT cord-005453-4057qib7 14201 43 results result NNS cord-005453-4057qib7 14201 44 are be VBP cord-005453-4057qib7 14201 45 extremely extremely RB cord-005453-4057qib7 14201 46 poor poor JJ cord-005453-4057qib7 14201 47 . . . cord-005453-4057qib7 14202 1 For for IN cord-005453-4057qib7 14202 2 these these DT cord-005453-4057qib7 14202 3 patients patient NNS cord-005453-4057qib7 14202 4 allografting allografte VBG cord-005453-4057qib7 14202 5 ( ( -LRB- cord-005453-4057qib7 14202 6 allo allo NN cord-005453-4057qib7 14202 7 - - HYPH cord-005453-4057qib7 14202 8 HSCT HSCT NNP cord-005453-4057qib7 14202 9 ) ) -RRB- cord-005453-4057qib7 14202 10 may may MD cord-005453-4057qib7 14202 11 offer offer VB cord-005453-4057qib7 14202 12 some some DT cord-005453-4057qib7 14202 13 hope hope NN cord-005453-4057qib7 14202 14 . . . cord-005453-4057qib7 14203 1 Methods method NNS cord-005453-4057qib7 14203 2 : : : cord-005453-4057qib7 14203 3 We -PRON- PRP cord-005453-4057qib7 14203 4 summarize summarize VBP cord-005453-4057qib7 14203 5 the the DT cord-005453-4057qib7 14203 6 experience experience NN cord-005453-4057qib7 14203 7 of of IN cord-005453-4057qib7 14203 8 83 83 CD cord-005453-4057qib7 14203 9 consecutive consecutive JJ cord-005453-4057qib7 14203 10 HR hr NN cord-005453-4057qib7 14203 11 NB NB NNP cord-005453-4057qib7 14203 12 patients patient NNS cord-005453-4057qib7 14203 13 receiving receive VBG cord-005453-4057qib7 14203 14 therapy therapy NN cord-005453-4057qib7 14203 15 in in IN cord-005453-4057qib7 14203 16 our -PRON- PRP$ cord-005453-4057qib7 14203 17 pediatric pediatric JJ cord-005453-4057qib7 14203 18 transplant transplant NN cord-005453-4057qib7 14203 19 department department NN cord-005453-4057qib7 14203 20 in in IN cord-005453-4057qib7 14203 21 2008 2008 CD cord-005453-4057qib7 14203 22 - - SYM cord-005453-4057qib7 14203 23 2017 2017 CD cord-005453-4057qib7 14203 24 . . . cord-005453-4057qib7 14204 1 The the DT cord-005453-4057qib7 14204 2 median median JJ cord-005453-4057qib7 14204 3 age age NN cord-005453-4057qib7 14204 4 was be VBD cord-005453-4057qib7 14204 5 4 4 CD cord-005453-4057qib7 14204 6 years year NNS cord-005453-4057qib7 14204 7 ( ( -LRB- cord-005453-4057qib7 14204 8 8 8 CD cord-005453-4057qib7 14204 9 months month NNS cord-005453-4057qib7 14204 10 to to IN cord-005453-4057qib7 14204 11 22 22 CD cord-005453-4057qib7 14204 12 years year NNS cord-005453-4057qib7 14204 13 ) ) -RRB- cord-005453-4057qib7 14204 14 . . . cord-005453-4057qib7 14205 1 A a DT cord-005453-4057qib7 14205 2 total total NN cord-005453-4057qib7 14205 3 of of IN cord-005453-4057qib7 14205 4 78 78 CD cord-005453-4057qib7 14205 5 auto auto NN cord-005453-4057qib7 14205 6 - - HYPH cord-005453-4057qib7 14205 7 HSCTs hsct NNS cord-005453-4057qib7 14205 8 and and CC cord-005453-4057qib7 14205 9 20 20 CD cord-005453-4057qib7 14205 10 allo allo NN cord-005453-4057qib7 14205 11 - - HYPH cord-005453-4057qib7 14205 12 HSCTs hsct NNS cord-005453-4057qib7 14205 13 were be VBD cord-005453-4057qib7 14205 14 performed perform VBN cord-005453-4057qib7 14205 15 . . . cord-005453-4057qib7 14206 1 All all DT cord-005453-4057qib7 14206 2 auto auto NN cord-005453-4057qib7 14206 3 - - HYPH cord-005453-4057qib7 14206 4 HSCT HSCT NNP cord-005453-4057qib7 14206 5 recipients recipient NNS cord-005453-4057qib7 14206 6 were be VBD cord-005453-4057qib7 14206 7 characterized characterize VBN cord-005453-4057qib7 14206 8 by by IN cord-005453-4057qib7 14206 9 one one CD cord-005453-4057qib7 14206 10 or or CC cord-005453-4057qib7 14206 11 several several JJ cord-005453-4057qib7 14206 12 high high JJ cord-005453-4057qib7 14206 13 - - HYPH cord-005453-4057qib7 14206 14 risk risk NN cord-005453-4057qib7 14206 15 features feature NNS cord-005453-4057qib7 14206 16 : : : cord-005453-4057qib7 14206 17 age age NN cord-005453-4057qib7 14206 18 of of IN cord-005453-4057qib7 14206 19 more more JJR cord-005453-4057qib7 14206 20 than than IN cord-005453-4057qib7 14206 21 18 18 CD cord-005453-4057qib7 14206 22 months month NNS cord-005453-4057qib7 14206 23 at at IN cord-005453-4057qib7 14206 24 disease disease NN cord-005453-4057qib7 14206 25 ( ( -LRB- cord-005453-4057qib7 14206 26 onset onset NNP cord-005453-4057qib7 14206 27 n=56 n=56 NNP cord-005453-4057qib7 14206 28 ) ) -RRB- cord-005453-4057qib7 14206 29 , , , cord-005453-4057qib7 14206 30 primary primary JJ cord-005453-4057qib7 14206 31 disseminated disseminate VBN cord-005453-4057qib7 14206 32 disease disease NN cord-005453-4057qib7 14206 33 ( ( -LRB- cord-005453-4057qib7 14206 34 n=59 n=59 NNP cord-005453-4057qib7 14206 35 ) ) -RRB- cord-005453-4057qib7 14206 36 , , , cord-005453-4057qib7 14206 37 unfavorable unfavorable JJ cord-005453-4057qib7 14206 38 biologic biologic JJ cord-005453-4057qib7 14206 39 variant variant NN cord-005453-4057qib7 14206 40 ( ( -LRB- cord-005453-4057qib7 14206 41 n=29 n=29 NNP cord-005453-4057qib7 14206 42 ) ) -RRB- cord-005453-4057qib7 14206 43 , , , cord-005453-4057qib7 14206 44 poor poor JJ cord-005453-4057qib7 14206 45 1 1 CD cord-005453-4057qib7 14206 46 st st NNP cord-005453-4057qib7 14206 47 -line -line HYPH cord-005453-4057qib7 14206 48 therapy therapy NN cord-005453-4057qib7 14206 49 response response NN cord-005453-4057qib7 14206 50 ( ( -LRB- cord-005453-4057qib7 14206 51 n=16 n=16 NNP cord-005453-4057qib7 14206 52 ) ) -RRB- cord-005453-4057qib7 14206 53 or or CC cord-005453-4057qib7 14206 54 systemic systemic JJ cord-005453-4057qib7 14206 55 relapse relapse NN cord-005453-4057qib7 14206 56 ( ( -LRB- cord-005453-4057qib7 14206 57 n=9 n=9 NN cord-005453-4057qib7 14206 58 ) ) -RRB- cord-005453-4057qib7 14206 59 . . . cord-005453-4057qib7 14207 1 Most Most JJS cord-005453-4057qib7 14207 2 patients patient NNS cord-005453-4057qib7 14207 3 ( ( -LRB- cord-005453-4057qib7 14207 4 n=75 n=75 NN cord-005453-4057qib7 14207 5 ) ) -RRB- cord-005453-4057qib7 14207 6 received receive VBN cord-005453-4057qib7 14207 7 Bu Bu NNP cord-005453-4057qib7 14207 8 - - HYPH cord-005453-4057qib7 14207 9 Mel Mel NNP cord-005453-4057qib7 14207 10 HDCT HDCT NNP cord-005453-4057qib7 14207 11 ( ( -LRB- cord-005453-4057qib7 14207 12 in in IN cord-005453-4057qib7 14207 13 younger young JJR cord-005453-4057qib7 14207 14 patients patient NNS cord-005453-4057qib7 14207 15 oral oral JJ cord-005453-4057qib7 14207 16 busulfan busulfan NN cord-005453-4057qib7 14207 17 was be VBD cord-005453-4057qib7 14207 18 replaced replace VBN cord-005453-4057qib7 14207 19 by by IN cord-005453-4057qib7 14207 20 Busilvex Busilvex NNP cord-005453-4057qib7 14207 21 ) ) -RRB- cord-005453-4057qib7 14207 22 , , , cord-005453-4057qib7 14207 23 in in IN cord-005453-4057qib7 14207 24 3 3 CD cord-005453-4057qib7 14207 25 primary primary JJ cord-005453-4057qib7 14207 26 resistant resistant JJ cord-005453-4057qib7 14207 27 cases case NNS cord-005453-4057qib7 14207 28 a a DT cord-005453-4057qib7 14207 29 5D/5D 5d/5d CD cord-005453-4057qib7 14207 30 regimen regimen NN cord-005453-4057qib7 14207 31 was be VBD cord-005453-4057qib7 14207 32 used use VBN cord-005453-4057qib7 14207 33 . . . cord-005453-4057qib7 14208 1 A a DT cord-005453-4057qib7 14208 2 total total NN cord-005453-4057qib7 14208 3 of of IN cord-005453-4057qib7 14208 4 20 20 CD cord-005453-4057qib7 14208 5 patients patient NNS cord-005453-4057qib7 14208 6 with with IN cord-005453-4057qib7 14208 7 1st 1st NN cord-005453-4057qib7 14208 8 ( ( -LRB- cord-005453-4057qib7 14208 9 n=11 n=11 NNP cord-005453-4057qib7 14208 10 ) ) -RRB- cord-005453-4057qib7 14208 11 or or CC cord-005453-4057qib7 14208 12 2nd 2nd JJ cord-005453-4057qib7 14208 13 ( ( -LRB- cord-005453-4057qib7 14208 14 n=2 n=2 NNS cord-005453-4057qib7 14208 15 ) ) -RRB- cord-005453-4057qib7 14209 1 chemosensitive chemosensitive JJ cord-005453-4057qib7 14209 2 relapse relapse NN cord-005453-4057qib7 14209 3 , , , cord-005453-4057qib7 14209 4 resistant resistant JJ cord-005453-4057qib7 14209 5 relapse relapse NN cord-005453-4057qib7 14209 6 ( ( -LRB- cord-005453-4057qib7 14209 7 n=4 n=4 NNS cord-005453-4057qib7 14209 8 ) ) -RRB- cord-005453-4057qib7 14209 9 or or CC cord-005453-4057qib7 14209 10 poor poor JJ cord-005453-4057qib7 14209 11 mobilizers mobilizer NNS cord-005453-4057qib7 14209 12 with with IN cord-005453-4057qib7 14209 13 locally locally RB cord-005453-4057qib7 14209 14 advanced advanced JJ cord-005453-4057qib7 14209 15 resistant resistant JJ cord-005453-4057qib7 14209 16 tumor tumor NN cord-005453-4057qib7 14209 17 ( ( -LRB- cord-005453-4057qib7 14209 18 n=3 n=3 NN cord-005453-4057qib7 14209 19 ) ) -RRB- cord-005453-4057qib7 14210 1 received receive VBD cord-005453-4057qib7 14210 2 allo allo NN cord-005453-4057qib7 14210 3 - - HYPH cord-005453-4057qib7 14210 4 HSCT HSCT NNP cord-005453-4057qib7 14210 5 from from IN cord-005453-4057qib7 14210 6 haploidentical haploidentical JJ cord-005453-4057qib7 14210 7 donor donor NN cord-005453-4057qib7 14210 8 with with IN cord-005453-4057qib7 14210 9 fludarabine fludarabine NN cord-005453-4057qib7 14210 10 - - HYPH cord-005453-4057qib7 14210 11 based base VBN cord-005453-4057qib7 14210 12 RIC RIC NNP cord-005453-4057qib7 14210 13 . . . cord-005453-4057qib7 14211 1 In in IN cord-005453-4057qib7 14211 2 12 12 CD cord-005453-4057qib7 14211 3 cases case NNS cord-005453-4057qib7 14211 4 the the DT cord-005453-4057qib7 14211 5 transplant transplant NN cord-005453-4057qib7 14211 6 was be VBD cord-005453-4057qib7 14211 7 modified modify VBN cord-005453-4057qib7 14211 8 via via IN cord-005453-4057qib7 14211 9 immunomagnetic immunomagnetic JJ cord-005453-4057qib7 14211 10 positive positive JJ cord-005453-4057qib7 14211 11 or or CC cord-005453-4057qib7 14211 12 negative negative JJ cord-005453-4057qib7 14211 13 selection selection NN cord-005453-4057qib7 14211 14 , , , cord-005453-4057qib7 14211 15 8 8 CD cord-005453-4057qib7 14211 16 patients patient NNS cord-005453-4057qib7 14211 17 received receive VBD cord-005453-4057qib7 14211 18 post post JJ cord-005453-4057qib7 14211 19 - - JJ cord-005453-4057qib7 14211 20 transplant transplant NN cord-005453-4057qib7 14211 21 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14211 22 ( ( -LRB- cord-005453-4057qib7 14211 23 post post JJ cord-005453-4057qib7 14211 24 - - JJ cord-005453-4057qib7 14211 25 CY)-based cy)-based JJ cord-005453-4057qib7 14211 26 GVHD GVHD NNP cord-005453-4057qib7 14211 27 prophylaxis prophylaxis NN cord-005453-4057qib7 14211 28 . . . cord-005453-4057qib7 14212 1 GVHD GVHD NNP cord-005453-4057qib7 14212 2 prophylaxis prophylaxis NN cord-005453-4057qib7 14212 3 also also RB cord-005453-4057qib7 14212 4 consisted consist VBD cord-005453-4057qib7 14212 5 of of IN cord-005453-4057qib7 14212 6 calceneurin calceneurin NNP cord-005453-4057qib7 14212 7 inhibitors inhibitor NNS cord-005453-4057qib7 14212 8 and and CC cord-005453-4057qib7 14212 9 sirolimus sirolimus NN cord-005453-4057qib7 14212 10 . . . cord-005453-4057qib7 14213 1 Thirteen thirteen CD cord-005453-4057qib7 14213 2 of of IN cord-005453-4057qib7 14213 3 20 20 CD cord-005453-4057qib7 14213 4 allo allo NN cord-005453-4057qib7 14213 5 - - HYPH cord-005453-4057qib7 14213 6 HSCT HSCT NNP cord-005453-4057qib7 14213 7 recipients recipient NNS cord-005453-4057qib7 14213 8 received receive VBD cord-005453-4057qib7 14213 9 posttransplant posttransplant NNP cord-005453-4057qib7 14213 10 immunoadoptive immunoadoptive NNP cord-005453-4057qib7 14213 11 ( ( -LRB- cord-005453-4057qib7 14213 12 n=6 n=6 NNP cord-005453-4057qib7 14213 13 ) ) -RRB- cord-005453-4057qib7 14213 14 or or CC cord-005453-4057qib7 14213 15 targeted target VBN cord-005453-4057qib7 14213 16 ( ( -LRB- cord-005453-4057qib7 14213 17 n=7 n=7 JJ cord-005453-4057qib7 14213 18 ) ) -RRB- cord-005453-4057qib7 14213 19 therapy therapy NN cord-005453-4057qib7 14213 20 . . . cord-005453-4057qib7 14214 1 Results result NNS cord-005453-4057qib7 14214 2 : : : cord-005453-4057qib7 14215 1 The the DT cord-005453-4057qib7 14215 2 5-year 5-year CD cord-005453-4057qib7 14215 3 OS OS NNP cord-005453-4057qib7 14215 4 and and CC cord-005453-4057qib7 14215 5 EFS efs NN cord-005453-4057qib7 14215 6 in in IN cord-005453-4057qib7 14215 7 auto auto NN cord-005453-4057qib7 14215 8 - - HYPH cord-005453-4057qib7 14215 9 HSCT HSCT NNP cord-005453-4057qib7 14215 10 recipients recipient NNS cord-005453-4057qib7 14215 11 was be VBD cord-005453-4057qib7 14215 12 48 48 CD cord-005453-4057qib7 14215 13 % % NN cord-005453-4057qib7 14215 14 and and CC cord-005453-4057qib7 14215 15 36 36 CD cord-005453-4057qib7 14215 16 % % NN cord-005453-4057qib7 14215 17 , , , cord-005453-4057qib7 14215 18 accordingly accordingly RB cord-005453-4057qib7 14215 19 . . . cord-005453-4057qib7 14216 1 All all DT cord-005453-4057qib7 14216 2 but but IN cord-005453-4057qib7 14216 3 one one CD cord-005453-4057qib7 14216 4 patient patient NN cord-005453-4057qib7 14216 5 engrafted engraft VBD cord-005453-4057qib7 14216 6 with with IN cord-005453-4057qib7 14216 7 a a DT cord-005453-4057qib7 14216 8 median median JJ cord-005453-4057qib7 14216 9 time time NN cord-005453-4057qib7 14216 10 of of IN cord-005453-4057qib7 14216 11 17 17 CD cord-005453-4057qib7 14216 12 ( ( -LRB- cord-005453-4057qib7 14216 13 11 11 CD cord-005453-4057qib7 14216 14 - - SYM cord-005453-4057qib7 14216 15 51 51 CD cord-005453-4057qib7 14216 16 ) ) -RRB- cord-005453-4057qib7 14216 17 days day NNS cord-005453-4057qib7 14216 18 . . . cord-005453-4057qib7 14217 1 Bu Bu NNP cord-005453-4057qib7 14217 2 - - HYPH cord-005453-4057qib7 14217 3 Mel Mel NNP cord-005453-4057qib7 14217 4 regimen regimen NN cord-005453-4057qib7 14217 5 was be VBD cord-005453-4057qib7 14217 6 characterized characterize VBN cord-005453-4057qib7 14217 7 by by IN cord-005453-4057qib7 14217 8 acceptable acceptable JJ cord-005453-4057qib7 14217 9 toxicity toxicity NN cord-005453-4057qib7 14217 10 with with IN cord-005453-4057qib7 14217 11 most most JJS cord-005453-4057qib7 14217 12 common common JJ cord-005453-4057qib7 14217 13 toxicities toxicity NNS cord-005453-4057qib7 14217 14 being be VBG cord-005453-4057qib7 14217 15 oral oral JJ cord-005453-4057qib7 14217 16 mucositis mucositis NN cord-005453-4057qib7 14217 17 and and CC cord-005453-4057qib7 14217 18 infectious infectious JJ cord-005453-4057qib7 14217 19 complications complication NNS cord-005453-4057qib7 14217 20 . . . cord-005453-4057qib7 14218 1 The the DT cord-005453-4057qib7 14218 2 VOD VOD NNP cord-005453-4057qib7 14218 3 / / SYM cord-005453-4057qib7 14218 4 SOS SOS NNP cord-005453-4057qib7 14218 5 incidence incidence NN cord-005453-4057qib7 14218 6 was be VBD cord-005453-4057qib7 14218 7 only only RB cord-005453-4057qib7 14218 8 3 3 CD cord-005453-4057qib7 14218 9 % % NN cord-005453-4057qib7 14218 10 . . . cord-005453-4057qib7 14219 1 Four four CD cord-005453-4057qib7 14219 2 patients patient NNS cord-005453-4057qib7 14219 3 dies die VBZ cord-005453-4057qib7 14219 4 due due IN cord-005453-4057qib7 14219 5 to to IN cord-005453-4057qib7 14219 6 infection infection NN cord-005453-4057qib7 14219 7 ( ( -LRB- cord-005453-4057qib7 14219 8 n=2 n=2 NNS cord-005453-4057qib7 14219 9 ) ) -RRB- cord-005453-4057qib7 14219 10 , , , cord-005453-4057qib7 14219 11 CNS CNS NNP cord-005453-4057qib7 14219 12 hemorrhage hemorrhage NN cord-005453-4057qib7 14219 13 ( ( -LRB- cord-005453-4057qib7 14219 14 n=1 n=1 CD cord-005453-4057qib7 14219 15 ) ) -RRB- cord-005453-4057qib7 14219 16 , , , cord-005453-4057qib7 14219 17 and and CC cord-005453-4057qib7 14219 18 secondary secondary JJ cord-005453-4057qib7 14219 19 leukemia leukemia NN cord-005453-4057qib7 14219 20 ( ( -LRB- cord-005453-4057qib7 14219 21 n=1 n=1 NN cord-005453-4057qib7 14219 22 ) ) -RRB- cord-005453-4057qib7 14219 23 . . . cord-005453-4057qib7 14220 1 According accord VBG cord-005453-4057qib7 14220 2 to to IN cord-005453-4057qib7 14220 3 multivariate multivariate JJ cord-005453-4057qib7 14220 4 analysis analysis NN cord-005453-4057qib7 14220 5 the the DT cord-005453-4057qib7 14220 6 most most RBS cord-005453-4057qib7 14220 7 important important JJ cord-005453-4057qib7 14220 8 prognostic prognostic JJ cord-005453-4057qib7 14220 9 factors factor NNS cord-005453-4057qib7 14220 10 were be VBD cord-005453-4057qib7 14220 11 response response NN cord-005453-4057qib7 14220 12 to to IN cord-005453-4057qib7 14220 13 1 1 CD cord-005453-4057qib7 14220 14 st st NNP cord-005453-4057qib7 14220 15 line line NN cord-005453-4057qib7 14220 16 therapy therapy NN cord-005453-4057qib7 14220 17 and and CC cord-005453-4057qib7 14220 18 post post VB cord-005453-4057qib7 14220 19 auto auto NN cord-005453-4057qib7 14220 20 - - HYPH cord-005453-4057qib7 14220 21 HSCT HSCT NNP cord-005453-4057qib7 14220 22 MIBG MIBG NNP cord-005453-4057qib7 14220 23 scan scan JJ cord-005453-4057qib7 14220 24 results result NNS cord-005453-4057qib7 14220 25 . . . cord-005453-4057qib7 14221 1 The the DT cord-005453-4057qib7 14221 2 prognosis prognosis NN cord-005453-4057qib7 14221 3 in in IN cord-005453-4057qib7 14221 4 initially initially RB cord-005453-4057qib7 14221 5 resistant resistant JJ cord-005453-4057qib7 14221 6 patients patient NNS cord-005453-4057qib7 14221 7 with with IN cord-005453-4057qib7 14221 8 good good JJ cord-005453-4057qib7 14221 9 response response NN cord-005453-4057qib7 14221 10 to to IN cord-005453-4057qib7 14221 11 2 2 CD cord-005453-4057qib7 14221 12 nd nd NNP cord-005453-4057qib7 14221 13 or or CC cord-005453-4057qib7 14221 14 3 3 CD cord-005453-4057qib7 14221 15 rd rd NN cord-005453-4057qib7 14221 16 -line -line NN cord-005453-4057qib7 14221 17 therapy therapy NN cord-005453-4057qib7 14221 18 was be VBD cord-005453-4057qib7 14221 19 still still RB cord-005453-4057qib7 14221 20 very very RB cord-005453-4057qib7 14221 21 poor poor JJ cord-005453-4057qib7 14222 1 ( ( -LRB- cord-005453-4057qib7 14222 2 all all DT cord-005453-4057qib7 14222 3 patients patient NNS cord-005453-4057qib7 14222 4 relapsed relapse VBD cord-005453-4057qib7 14222 5 with with IN cord-005453-4057qib7 14222 6 the the DT cord-005453-4057qib7 14222 7 median median JJ cord-005453-4057qib7 14222 8 EFS efs NN cord-005453-4057qib7 14222 9 of of IN cord-005453-4057qib7 14222 10 12 12 CD cord-005453-4057qib7 14222 11 months month NNS cord-005453-4057qib7 14222 12 ) ) -RRB- cord-005453-4057qib7 14222 13 . . . cord-005453-4057qib7 14223 1 All all DT cord-005453-4057qib7 14223 2 patients patient NNS cord-005453-4057qib7 14223 3 receiving receive VBG cord-005453-4057qib7 14223 4 a a DT cord-005453-4057qib7 14223 5 second second JJ cord-005453-4057qib7 14223 6 auto auto NN cord-005453-4057qib7 14223 7 - - HYPH cord-005453-4057qib7 14223 8 HSCT HSCT NNP cord-005453-4057qib7 14223 9 after after IN cord-005453-4057qib7 14223 10 relapse relapse NN cord-005453-4057qib7 14223 11 died die VBD cord-005453-4057qib7 14223 12 due due IN cord-005453-4057qib7 14223 13 to to IN cord-005453-4057qib7 14223 14 disease disease NN cord-005453-4057qib7 14223 15 progression progression NN cord-005453-4057qib7 14223 16 . . . cord-005453-4057qib7 14224 1 With with IN cord-005453-4057qib7 14224 2 a a DT cord-005453-4057qib7 14224 3 median median NN cord-005453-4057qib7 14224 4 follow follow NN cord-005453-4057qib7 14224 5 up up IN cord-005453-4057qib7 14224 6 of of IN cord-005453-4057qib7 14224 7 6 6 CD cord-005453-4057qib7 14224 8 ( ( -LRB- cord-005453-4057qib7 14224 9 1 1 CD cord-005453-4057qib7 14224 10 - - SYM cord-005453-4057qib7 14224 11 80 80 CD cord-005453-4057qib7 14224 12 ) ) -RRB- cord-005453-4057qib7 14224 13 months month NNS cord-005453-4057qib7 14224 14 9 9 CD cord-005453-4057qib7 14224 15 allo allo NN cord-005453-4057qib7 14224 16 - - HYPH cord-005453-4057qib7 14224 17 HSCT HSCT NNP cord-005453-4057qib7 14224 18 recipients recipient NNS cord-005453-4057qib7 14224 19 are be VBP cord-005453-4057qib7 14224 20 alive alive JJ cord-005453-4057qib7 14224 21 , , , cord-005453-4057qib7 14224 22 6 6 CD cord-005453-4057qib7 14224 23 of of IN cord-005453-4057qib7 14224 24 them -PRON- PRP cord-005453-4057qib7 14224 25 with with IN cord-005453-4057qib7 14224 26 no no DT cord-005453-4057qib7 14224 27 signs sign NNS cord-005453-4057qib7 14224 28 of of IN cord-005453-4057qib7 14224 29 disease disease NN cord-005453-4057qib7 14224 30 progression progression NN cord-005453-4057qib7 14224 31 . . . cord-005453-4057qib7 14225 1 All all DT cord-005453-4057qib7 14225 2 long long JJ cord-005453-4057qib7 14225 3 - - HYPH cord-005453-4057qib7 14225 4 term term NN cord-005453-4057qib7 14225 5 responders responder NNS cord-005453-4057qib7 14225 6 received receive VBD cord-005453-4057qib7 14225 7 post post JJ cord-005453-4057qib7 14225 8 - - JJ cord-005453-4057qib7 14225 9 transplant transplant JJ cord-005453-4057qib7 14225 10 therapy therapy NN cord-005453-4057qib7 14225 11 . . . cord-005453-4057qib7 14226 1 One one CD cord-005453-4057qib7 14226 2 patient patient NN cord-005453-4057qib7 14226 3 died die VBD cord-005453-4057qib7 14226 4 due due IN cord-005453-4057qib7 14226 5 to to IN cord-005453-4057qib7 14226 6 transplant transplant NN cord-005453-4057qib7 14226 7 complications complication NNS cord-005453-4057qib7 14226 8 , , , cord-005453-4057qib7 14226 9 other other JJ cord-005453-4057qib7 14226 10 deaths death NNS cord-005453-4057qib7 14226 11 were be VBD cord-005453-4057qib7 14226 12 caused cause VBN cord-005453-4057qib7 14226 13 by by IN cord-005453-4057qib7 14226 14 disease disease NN cord-005453-4057qib7 14226 15 progression progression NN cord-005453-4057qib7 14226 16 . . . cord-005453-4057qib7 14227 1 There there EX cord-005453-4057qib7 14227 2 was be VBD cord-005453-4057qib7 14227 3 no no DT cord-005453-4057qib7 14227 4 obvious obvious JJ cord-005453-4057qib7 14227 5 difference difference NN cord-005453-4057qib7 14227 6 between between IN cord-005453-4057qib7 14227 7 outcomes outcome NNS cord-005453-4057qib7 14227 8 in in IN cord-005453-4057qib7 14227 9 post post JJ cord-005453-4057qib7 14227 10 - - JJ cord-005453-4057qib7 14227 11 CY CY NNP cord-005453-4057qib7 14227 12 based base VBN cord-005453-4057qib7 14227 13 and and CC cord-005453-4057qib7 14227 14 transplant transplant NN cord-005453-4057qib7 14227 15 modification modification NN cord-005453-4057qib7 14227 16 - - HYPH cord-005453-4057qib7 14227 17 based base VBN cord-005453-4057qib7 14227 18 transplantations transplantation NNS cord-005453-4057qib7 14227 19 . . . cord-005453-4057qib7 14228 1 aGVHD aGVHD NNP cord-005453-4057qib7 14228 2 more more RBR cord-005453-4057qib7 14228 3 often often RB cord-005453-4057qib7 14228 4 developed develop VBN cord-005453-4057qib7 14228 5 in in IN cord-005453-4057qib7 14228 6 modified modify VBN cord-005453-4057qib7 14228 7 transplant transplant NN cord-005453-4057qib7 14228 8 recipients recipient NNS cord-005453-4057qib7 14228 9 ( ( -LRB- cord-005453-4057qib7 14228 10 8 8 CD cord-005453-4057qib7 14228 11 patients patient NNS cord-005453-4057qib7 14228 12 vs vs IN cord-005453-4057qib7 14228 13 2 2 CD cord-005453-4057qib7 14228 14 in in IN cord-005453-4057qib7 14228 15 post post JJ cord-005453-4057qib7 14228 16 - - JJ cord-005453-4057qib7 14228 17 CY CY NNP cord-005453-4057qib7 14228 18 group group NN cord-005453-4057qib7 14228 19 , , , cord-005453-4057qib7 14228 20 4 4 CD cord-005453-4057qib7 14228 21 of of IN cord-005453-4057qib7 14228 22 these these DT cord-005453-4057qib7 14228 23 cases case NNS cord-005453-4057qib7 14228 24 Gr Gr NNP cord-005453-4057qib7 14228 25 III III NNP cord-005453-4057qib7 14228 26 - - HYPH cord-005453-4057qib7 14228 27 IV IV NNP cord-005453-4057qib7 14228 28 ) ) -RRB- cord-005453-4057qib7 14228 29 , , , cord-005453-4057qib7 14228 30 3 3 CD cord-005453-4057qib7 14228 31 patients patient NNS cord-005453-4057qib7 14228 32 in in IN cord-005453-4057qib7 14228 33 post post JJ cord-005453-4057qib7 14228 34 - - JJ cord-005453-4057qib7 14228 35 CY CY NNP cord-005453-4057qib7 14228 36 group group NN cord-005453-4057qib7 14228 37 had have VBD cord-005453-4057qib7 14228 38 Grade Grade NNP cord-005453-4057qib7 14228 39 III III NNP cord-005453-4057qib7 14228 40 - - HYPH cord-005453-4057qib7 14228 41 IV IV NNP cord-005453-4057qib7 14228 42 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 14228 43 cystitis cystitis NN cord-005453-4057qib7 14228 44 . . . cord-005453-4057qib7 14229 1 The the DT cord-005453-4057qib7 14229 2 median median JJ cord-005453-4057qib7 14229 3 time time NN cord-005453-4057qib7 14229 4 to to IN cord-005453-4057qib7 14229 5 engraftment engraftment NN cord-005453-4057qib7 14229 6 was be VBD cord-005453-4057qib7 14229 7 longer long JJR cord-005453-4057qib7 14229 8 for for IN cord-005453-4057qib7 14229 9 PTCM PTCM NNP cord-005453-4057qib7 14229 10 group group NN cord-005453-4057qib7 14229 11 compared compare VBN cord-005453-4057qib7 14229 12 to to IN cord-005453-4057qib7 14229 13 transplant transplant NN cord-005453-4057qib7 14229 14 modification modification NN cord-005453-4057qib7 14229 15 group group NN cord-005453-4057qib7 14229 16 ( ( -LRB- cord-005453-4057qib7 14229 17 D d NN cord-005453-4057qib7 14229 18 +23 +23 NNS cord-005453-4057qib7 14229 19 vs. vs. FW cord-005453-4057qib7 14229 20 D+17 d+17 NN cord-005453-4057qib7 14229 21 , , , cord-005453-4057qib7 14229 22 accordingly accordingly RB cord-005453-4057qib7 14229 23 ) ) -RRB- cord-005453-4057qib7 14229 24 . . . cord-005453-4057qib7 14230 1 Conclusions conclusion NNS cord-005453-4057qib7 14230 2 : : : cord-005453-4057qib7 14231 1 While while IN cord-005453-4057qib7 14231 2 single single JJ cord-005453-4057qib7 14231 3 HSCT HSCT NNP cord-005453-4057qib7 14231 4 with with IN cord-005453-4057qib7 14231 5 auto auto NN cord-005453-4057qib7 14231 6 - - HYPH cord-005453-4057qib7 14231 7 HSCT HSCT NNP cord-005453-4057qib7 14231 8 is be VBZ cord-005453-4057qib7 14231 9 a a DT cord-005453-4057qib7 14231 10 golden golden JJ cord-005453-4057qib7 14231 11 standard standard NN cord-005453-4057qib7 14231 12 in in IN cord-005453-4057qib7 14231 13 HR HR NNP cord-005453-4057qib7 14231 14 NB NB NNP cord-005453-4057qib7 14231 15 patients patient NNS cord-005453-4057qib7 14231 16 , , , cord-005453-4057qib7 14231 17 the the DT cord-005453-4057qib7 14231 18 relapse relapse NN cord-005453-4057qib7 14231 19 rate rate NN cord-005453-4057qib7 14231 20 is be VBZ cord-005453-4057qib7 14231 21 still still RB cord-005453-4057qib7 14231 22 high high JJ cord-005453-4057qib7 14231 23 and and CC cord-005453-4057qib7 14231 24 the the DT cord-005453-4057qib7 14231 25 prognosis prognosis NN cord-005453-4057qib7 14231 26 in in IN cord-005453-4057qib7 14231 27 relapsed relapse VBN cord-005453-4057qib7 14231 28 / / SYM cord-005453-4057qib7 14231 29 refractory refractory JJ cord-005453-4057qib7 14231 30 patients patient NNS cord-005453-4057qib7 14231 31 is be VBZ cord-005453-4057qib7 14231 32 dismal dismal JJ cord-005453-4057qib7 14231 33 . . . cord-005453-4057qib7 14232 1 The the DT cord-005453-4057qib7 14232 2 allografting allografting NN cord-005453-4057qib7 14232 3 has have VBZ cord-005453-4057qib7 14232 4 some some DT cord-005453-4057qib7 14232 5 limited limited JJ cord-005453-4057qib7 14232 6 effectiveness effectiveness NN cord-005453-4057qib7 14232 7 in in IN cord-005453-4057qib7 14232 8 these these DT cord-005453-4057qib7 14232 9 cases case NNS cord-005453-4057qib7 14232 10 and and CC cord-005453-4057qib7 14232 11 post post JJ cord-005453-4057qib7 14232 12 - - JJ cord-005453-4057qib7 14232 13 transplant transplant NN cord-005453-4057qib7 14232 14 therapy therapy NN cord-005453-4057qib7 14232 15 has have VBZ cord-005453-4057qib7 14232 16 a a DT cord-005453-4057qib7 14232 17 potential potential NN cord-005453-4057qib7 14232 18 for for IN cord-005453-4057qib7 14232 19 further further JJ cord-005453-4057qib7 14232 20 improvement improvement NN cord-005453-4057qib7 14232 21 . . . cord-005453-4057qib7 14233 1 Disclosure disclosure NN cord-005453-4057qib7 14233 2 : : : cord-005453-4057qib7 14233 3 Nothing nothing NN cord-005453-4057qib7 14233 4 to to TO cord-005453-4057qib7 14233 5 declare declare VB cord-005453-4057qib7 14233 6 P654 P654 NNP cord-005453-4057qib7 14233 7 Abstract Abstract NNP cord-005453-4057qib7 14233 8 already already RB cord-005453-4057qib7 14233 9 published publish VBN cord-005453-4057qib7 14233 10 . . . cord-005453-4057qib7 14234 1 Veno Veno NNP cord-005453-4057qib7 14234 2 - - HYPH cord-005453-4057qib7 14234 3 occlusive occlusive JJ cord-005453-4057qib7 14234 4 liver liver NN cord-005453-4057qib7 14234 5 disease disease NN cord-005453-4057qib7 14234 6 ( ( -LRB- cord-005453-4057qib7 14234 7 VOD VOD NNP cord-005453-4057qib7 14234 8 ) ) -RRB- cord-005453-4057qib7 14234 9 is be VBZ cord-005453-4057qib7 14234 10 frequent frequent JJ cord-005453-4057qib7 14234 11 but but CC cord-005453-4057qib7 14234 12 well well RB cord-005453-4057qib7 14234 13 treatable treatable JJ cord-005453-4057qib7 14234 14 with with IN cord-005453-4057qib7 14234 15 early early JJ cord-005453-4057qib7 14234 16 defibrotide defibrotide NNP cord-005453-4057qib7 14234 17 administration administration NN cord-005453-4057qib7 14234 18 in in IN cord-005453-4057qib7 14234 19 children child NNS cord-005453-4057qib7 14234 20 with with IN cord-005453-4057qib7 14234 21 neuroblastoma neuroblastoma NN cord-005453-4057qib7 14234 22 receiving receive VBG cord-005453-4057qib7 14234 23 high high JJ cord-005453-4057qib7 14234 24 - - HYPH cord-005453-4057qib7 14234 25 dose dose NN cord-005453-4057qib7 14234 26 busulfan busulfan NN cord-005453-4057qib7 14234 27 and and CC cord-005453-4057qib7 14234 28 melphalan melphalan NNP cord-005453-4057qib7 14234 29 Background Background NNP cord-005453-4057qib7 14234 30 : : : cord-005453-4057qib7 14234 31 Using use VBG cord-005453-4057qib7 14234 32 high high JJ cord-005453-4057qib7 14234 33 - - HYPH cord-005453-4057qib7 14234 34 dose dose NN cord-005453-4057qib7 14234 35 intravenous intravenous JJ cord-005453-4057qib7 14234 36 busulfan busulfan NN cord-005453-4057qib7 14234 37 and and CC cord-005453-4057qib7 14234 38 melphalan melphalan NNP cord-005453-4057qib7 14235 1 ( ( -LRB- cord-005453-4057qib7 14235 2 BuMel BuMel NNP cord-005453-4057qib7 14235 3 ) ) -RRB- cord-005453-4057qib7 14235 4 prior prior RB cord-005453-4057qib7 14235 5 to to IN cord-005453-4057qib7 14235 6 autologous autologous JJ cord-005453-4057qib7 14235 7 stem stem NN cord-005453-4057qib7 14235 8 cell cell NN cord-005453-4057qib7 14235 9 transplantation transplantation NN cord-005453-4057qib7 14235 10 ( ( -LRB- cord-005453-4057qib7 14235 11 SCT SCT NNP cord-005453-4057qib7 14235 12 ) ) -RRB- cord-005453-4057qib7 14235 13 in in IN cord-005453-4057qib7 14235 14 children child NNS cord-005453-4057qib7 14235 15 with with IN cord-005453-4057qib7 14235 16 high high JJ cord-005453-4057qib7 14235 17 - - HYPH cord-005453-4057qib7 14235 18 risk risk NN cord-005453-4057qib7 14235 19 neuroblastoma neuroblastoma NN cord-005453-4057qib7 14235 20 , , , cord-005453-4057qib7 14235 21 seems seem VBZ cord-005453-4057qib7 14235 22 to to TO cord-005453-4057qib7 14235 23 decrease decrease VB cord-005453-4057qib7 14235 24 toxicity toxicity NN cord-005453-4057qib7 14235 25 of of IN cord-005453-4057qib7 14235 26 the the DT cord-005453-4057qib7 14235 27 myeloablative myeloablative JJ cord-005453-4057qib7 14235 28 regimen regimen NN cord-005453-4057qib7 14235 29 , , , cord-005453-4057qib7 14235 30 except except IN cord-005453-4057qib7 14235 31 for for IN cord-005453-4057qib7 14235 32 VOD VOD NNP cord-005453-4057qib7 14235 33 . . . cord-005453-4057qib7 14236 1 In in IN cord-005453-4057qib7 14236 2 this this DT cord-005453-4057qib7 14236 3 multicenter multicenter JJ cord-005453-4057qib7 14236 4 retrospective retrospective JJ cord-005453-4057qib7 14236 5 study study NN cord-005453-4057qib7 14236 6 we -PRON- PRP cord-005453-4057qib7 14236 7 aimed aim VBD cord-005453-4057qib7 14236 8 to to TO cord-005453-4057qib7 14236 9 assess assess VB cord-005453-4057qib7 14236 10 the the DT cord-005453-4057qib7 14236 11 outcome outcome NN cord-005453-4057qib7 14236 12 of of IN cord-005453-4057qib7 14236 13 BuMel BuMel NNP cord-005453-4057qib7 14236 14 - - HYPH cord-005453-4057qib7 14236 15 associated associate VBN cord-005453-4057qib7 14236 16 VOD VOD NNP cord-005453-4057qib7 14236 17 with with IN cord-005453-4057qib7 14236 18 early early JJ cord-005453-4057qib7 14236 19 defibrotide defibrotide NN cord-005453-4057qib7 14236 20 treatment treatment NN cord-005453-4057qib7 14236 21 intervention intervention NN cord-005453-4057qib7 14236 22 . . . cord-005453-4057qib7 14237 1 Methods method NNS cord-005453-4057qib7 14237 2 : : : cord-005453-4057qib7 14237 3 We -PRON- PRP cord-005453-4057qib7 14237 4 retrospectively retrospectively RB cord-005453-4057qib7 14237 5 analyzed analyze VBD cord-005453-4057qib7 14237 6 64 64 CD cord-005453-4057qib7 14237 7 children child NNS cord-005453-4057qib7 14237 8 with with IN cord-005453-4057qib7 14237 9 high high JJ cord-005453-4057qib7 14237 10 - - HYPH cord-005453-4057qib7 14237 11 risk risk NN cord-005453-4057qib7 14237 12 neuroblastoma neuroblastoma NN cord-005453-4057qib7 14237 13 who who WP cord-005453-4057qib7 14237 14 underwent undergo VBD cord-005453-4057qib7 14237 15 autologous autologous JJ cord-005453-4057qib7 14237 16 SCT SCT NNP cord-005453-4057qib7 14237 17 with with IN cord-005453-4057qib7 14237 18 i.v i.v NNP cord-005453-4057qib7 14237 19 . . . cord-005453-4057qib7 14238 1 BuMel BuMel NNP cord-005453-4057qib7 14238 2 regimen regimen NN cord-005453-4057qib7 14238 3 in in IN cord-005453-4057qib7 14238 4 Slovakia Slovakia NNP cord-005453-4057qib7 14238 5 and and CC cord-005453-4057qib7 14238 6 Prague Prague NNP cord-005453-4057qib7 14238 7 , , , cord-005453-4057qib7 14238 8 Czech Czech NNP cord-005453-4057qib7 14238 9 Republic Republic NNP cord-005453-4057qib7 14238 10 in in IN cord-005453-4057qib7 14238 11 the the DT cord-005453-4057qib7 14238 12 period period NN cord-005453-4057qib7 14239 1 1/2008 1/2008 LS cord-005453-4057qib7 14240 1 -10/2018 -10/2018 : cord-005453-4057qib7 14240 2 . . . cord-005453-4057qib7 14241 1 Busulfan Busulfan NNP cord-005453-4057qib7 14241 2 was be VBD cord-005453-4057qib7 14241 3 administered administer VBN cord-005453-4057qib7 14241 4 in in IN cord-005453-4057qib7 14241 5 q6 q6 NNP cord-005453-4057qib7 14241 6 hour hour NN cord-005453-4057qib7 14241 7 schedule schedule NN cord-005453-4057qib7 14241 8 , , , cord-005453-4057qib7 14241 9 with with IN cord-005453-4057qib7 14241 10 therapeutic therapeutic JJ cord-005453-4057qib7 14241 11 drug drug NN cord-005453-4057qib7 14241 12 level level NN cord-005453-4057qib7 14241 13 monitoring monitoring NN cord-005453-4057qib7 14241 14 in in IN cord-005453-4057qib7 14241 15 84 84 CD cord-005453-4057qib7 14241 16 % % NN cord-005453-4057qib7 14241 17 of of IN cord-005453-4057qib7 14241 18 patients patient NNS cord-005453-4057qib7 14241 19 . . . cord-005453-4057qib7 14242 1 All all DT cord-005453-4057qib7 14242 2 VOD VOD NNP cord-005453-4057qib7 14242 3 patients patient NNS cord-005453-4057qib7 14242 4 except except IN cord-005453-4057qib7 14242 5 one one CD cord-005453-4057qib7 14242 6 were be VBD cord-005453-4057qib7 14242 7 treated treat VBN cord-005453-4057qib7 14242 8 with with IN cord-005453-4057qib7 14242 9 defibrotide defibrotide NN cord-005453-4057qib7 14242 10 starting start VBG cord-005453-4057qib7 14242 11 at at IN cord-005453-4057qib7 14242 12 a a DT cord-005453-4057qib7 14242 13 standard standard JJ cord-005453-4057qib7 14242 14 dose dose NN cord-005453-4057qib7 14242 15 of of IN cord-005453-4057qib7 14242 16 25 25 CD cord-005453-4057qib7 14242 17 mg mg NNP cord-005453-4057qib7 14242 18 / / SYM cord-005453-4057qib7 14242 19 kg kg NNP cord-005453-4057qib7 14242 20 / / SYM cord-005453-4057qib7 14242 21 day day NN cord-005453-4057qib7 14242 22 , , , cord-005453-4057qib7 14242 23 given give VBN cord-005453-4057qib7 14242 24 in in IN cord-005453-4057qib7 14242 25 4 4 CD cord-005453-4057qib7 14242 26 doses dose NNS cord-005453-4057qib7 14242 27 per per IN cord-005453-4057qib7 14242 28 day day NN cord-005453-4057qib7 14242 29 . . . cord-005453-4057qib7 14243 1 1 1 CD cord-005453-4057qib7 14243 2 patient patient NN cord-005453-4057qib7 14243 3 was be VBD cord-005453-4057qib7 14243 4 treated treat VBN cord-005453-4057qib7 14243 5 with with IN cord-005453-4057qib7 14243 6 supportive supportive JJ cord-005453-4057qib7 14243 7 therapy therapy NN cord-005453-4057qib7 14243 8 only only RB cord-005453-4057qib7 14243 9 . . . cord-005453-4057qib7 14244 1 Ursodeoxycholic ursodeoxycholic JJ cord-005453-4057qib7 14244 2 acid acid NN cord-005453-4057qib7 14244 3 was be VBD cord-005453-4057qib7 14244 4 used use VBN cord-005453-4057qib7 14244 5 as as IN cord-005453-4057qib7 14244 6 prophylaxis prophylaxis NN cord-005453-4057qib7 14244 7 in in IN cord-005453-4057qib7 14244 8 all all DT cord-005453-4057qib7 14244 9 patients patient NNS cord-005453-4057qib7 14244 10 . . . cord-005453-4057qib7 14245 1 VOD VOD NNP cord-005453-4057qib7 14245 2 was be VBD cord-005453-4057qib7 14245 3 established establish VBN cord-005453-4057qib7 14245 4 using use VBG cord-005453-4057qib7 14245 5 the the DT cord-005453-4057qib7 14245 6 modified modify VBN cord-005453-4057qib7 14245 7 Seattle Seattle NNP cord-005453-4057qib7 14245 8 clinical clinical JJ cord-005453-4057qib7 14245 9 criteria criterion NNS cord-005453-4057qib7 14245 10 ( ( -LRB- cord-005453-4057qib7 14245 11 Corbacioglu Corbacioglu NNP cord-005453-4057qib7 14245 12 , , , cord-005453-4057qib7 14245 13 Lancet Lancet NNP cord-005453-4057qib7 14245 14 2012 2012 CD cord-005453-4057qib7 14245 15 ) ) -RRB- cord-005453-4057qib7 14245 16 . . . cord-005453-4057qib7 14246 1 Results result NNS cord-005453-4057qib7 14246 2 : : : cord-005453-4057qib7 14247 1 The the DT cord-005453-4057qib7 14247 2 incidence incidence NN cord-005453-4057qib7 14247 3 of of IN cord-005453-4057qib7 14247 4 VOD VOD NNP cord-005453-4057qib7 14247 5 was be VBD cord-005453-4057qib7 14247 6 23 23 CD cord-005453-4057qib7 14247 7 % % NN cord-005453-4057qib7 14247 8 ( ( -LRB- cord-005453-4057qib7 14247 9 15/64 15/64 CD cord-005453-4057qib7 14247 10 ) ) -RRB- cord-005453-4057qib7 14247 11 in in IN cord-005453-4057qib7 14247 12 patients patient NNS cord-005453-4057qib7 14247 13 treated treat VBN cord-005453-4057qib7 14247 14 with with IN cord-005453-4057qib7 14247 15 intravenous intravenous JJ cord-005453-4057qib7 14247 16 busulfan busulfan NN cord-005453-4057qib7 14247 17 and and CC cord-005453-4057qib7 14247 18 melphalan melphalan NNP cord-005453-4057qib7 14247 19 . . . cord-005453-4057qib7 14248 1 There there EX cord-005453-4057qib7 14248 2 was be VBD cord-005453-4057qib7 14248 3 no no DT cord-005453-4057qib7 14248 4 significant significant JJ cord-005453-4057qib7 14248 5 difference difference NN cord-005453-4057qib7 14248 6 in in IN cord-005453-4057qib7 14248 7 busulfan busulfan NN cord-005453-4057qib7 14248 8 total total JJ cord-005453-4057qib7 14248 9 dose dose NN cord-005453-4057qib7 14248 10 / / SYM cord-005453-4057qib7 14248 11 kg kg NNS cord-005453-4057qib7 14248 12 between between IN cord-005453-4057qib7 14248 13 patients patient NNS cord-005453-4057qib7 14248 14 with with IN cord-005453-4057qib7 14248 15 ( ( -LRB- cord-005453-4057qib7 14248 16 19.2 19.2 CD cord-005453-4057qib7 14248 17 mg mg NNP cord-005453-4057qib7 14248 18 / / SYM cord-005453-4057qib7 14248 19 kg kg NNP cord-005453-4057qib7 14248 20 ( ( -LRB- cord-005453-4057qib7 14248 21 SD=1,8 SD=1,8 NNP cord-005453-4057qib7 14248 22 ) ) -RRB- cord-005453-4057qib7 14248 23 ) ) -RRB- cord-005453-4057qib7 14248 24 and and CC cord-005453-4057qib7 14248 25 without without IN cord-005453-4057qib7 14248 26 ( ( -LRB- cord-005453-4057qib7 14248 27 18.0 18.0 CD cord-005453-4057qib7 14248 28 mg mg NNP cord-005453-4057qib7 14248 29 / / SYM cord-005453-4057qib7 14248 30 kg kg NNP cord-005453-4057qib7 14248 31 ( ( -LRB- cord-005453-4057qib7 14248 32 SD=2,4 sd=2,4 NN cord-005453-4057qib7 14248 33 ) ) -RRB- cord-005453-4057qib7 14248 34 ) ) -RRB- cord-005453-4057qib7 14249 1 VOD VOD NNP cord-005453-4057qib7 14249 2 manifestation manifestation NN cord-005453-4057qib7 14249 3 . . . cord-005453-4057qib7 14250 1 VOD VOD NNP cord-005453-4057qib7 14250 2 developed develop VBD cord-005453-4057qib7 14250 3 at at IN cord-005453-4057qib7 14250 4 a a DT cord-005453-4057qib7 14250 5 median median NN cord-005453-4057qib7 14250 6 of of IN cord-005453-4057qib7 14250 7 17 17 CD cord-005453-4057qib7 14250 8 days day NNS cord-005453-4057qib7 14250 9 after after IN cord-005453-4057qib7 14250 10 SCT SCT NNP cord-005453-4057qib7 14250 11 ( ( -LRB- cord-005453-4057qib7 14250 12 range range VBP cord-005453-4057qib7 14250 13 11 11 CD cord-005453-4057qib7 14250 14 -22 -22 CD cord-005453-4057qib7 14250 15 days day NNS cord-005453-4057qib7 14250 16 ) ) -RRB- cord-005453-4057qib7 14250 17 . . . cord-005453-4057qib7 14251 1 Anicteric Anicteric NNP cord-005453-4057qib7 14251 2 forms form NNS cord-005453-4057qib7 14251 3 of of IN cord-005453-4057qib7 14251 4 VOD VOD NNP cord-005453-4057qib7 14251 5 were be VBD cord-005453-4057qib7 14251 6 documented document VBN cord-005453-4057qib7 14251 7 , , , cord-005453-4057qib7 14251 8 although although IN cord-005453-4057qib7 14251 9 73 73 CD cord-005453-4057qib7 14251 10 % % NN cord-005453-4057qib7 14251 11 patients patient NNS cord-005453-4057qib7 14251 12 with with IN cord-005453-4057qib7 14251 13 VOD VOD NNP cord-005453-4057qib7 14251 14 ( ( -LRB- cord-005453-4057qib7 14251 15 11/15 11/15 CD cord-005453-4057qib7 14251 16 ) ) -RRB- cord-005453-4057qib7 14251 17 presented present VBN cord-005453-4057qib7 14251 18 with with IN cord-005453-4057qib7 14251 19 increased increase VBN cord-005453-4057qib7 14251 20 bilirubin bilirubin NN cord-005453-4057qib7 14251 21 . . . cord-005453-4057qib7 14252 1 73 73 CD cord-005453-4057qib7 14252 2 % % NN cord-005453-4057qib7 14252 3 patients patient NNS cord-005453-4057qib7 14252 4 with with IN cord-005453-4057qib7 14252 5 VOD VOD NNP cord-005453-4057qib7 14252 6 ( ( -LRB- cord-005453-4057qib7 14252 7 11/15 11/15 CD cord-005453-4057qib7 14252 8 ) ) -RRB- cord-005453-4057qib7 14252 9 developed develop VBN cord-005453-4057qib7 14252 10 ascites ascites NN cord-005453-4057qib7 14252 11 but but CC cord-005453-4057qib7 14252 12 only only RB cord-005453-4057qib7 14252 13 4 4 CD cord-005453-4057qib7 14252 14 patients patient NNS cord-005453-4057qib7 14252 15 ( ( -LRB- cord-005453-4057qib7 14252 16 27 27 CD cord-005453-4057qib7 14252 17 % % NN cord-005453-4057qib7 14252 18 ) ) -RRB- cord-005453-4057qib7 14253 1 required required NNP cord-005453-4057qib7 14253 2 ascites ascites NN cord-005453-4057qib7 14253 3 drainage drainage NN cord-005453-4057qib7 14253 4 . . . cord-005453-4057qib7 14254 1 No no DT cord-005453-4057qib7 14254 2 VOD VOD NNP cord-005453-4057qib7 14254 3 patient patient NN cord-005453-4057qib7 14254 4 received receive VBD cord-005453-4057qib7 14254 5 renal renal JJ cord-005453-4057qib7 14254 6 replacement replacement NN cord-005453-4057qib7 14254 7 therapy therapy NN cord-005453-4057qib7 14254 8 and and CC cord-005453-4057qib7 14254 9 only only RB cord-005453-4057qib7 14254 10 one one CD cord-005453-4057qib7 14254 11 needed need VBN cord-005453-4057qib7 14254 12 mechanical mechanical JJ cord-005453-4057qib7 14254 13 ventilation ventilation NN cord-005453-4057qib7 14254 14 . . . cord-005453-4057qib7 14255 1 Importantly importantly RB cord-005453-4057qib7 14255 2 , , , cord-005453-4057qib7 14255 3 we -PRON- PRP cord-005453-4057qib7 14255 4 successfully successfully RB cord-005453-4057qib7 14255 5 treated treat VBD cord-005453-4057qib7 14255 6 VOD VOD NNP cord-005453-4057qib7 14255 7 in in IN cord-005453-4057qib7 14255 8 all all DT cord-005453-4057qib7 14255 9 patients patient NNS cord-005453-4057qib7 14255 10 . . . cord-005453-4057qib7 14256 1 Relapse relapse NN cord-005453-4057qib7 14256 2 or or CC cord-005453-4057qib7 14256 3 progression progression NN cord-005453-4057qib7 14256 4 of of IN cord-005453-4057qib7 14256 5 neuroblastoma neuroblastoma NN cord-005453-4057qib7 14256 6 was be VBD cord-005453-4057qib7 14256 7 the the DT cord-005453-4057qib7 14256 8 cause cause NN cord-005453-4057qib7 14256 9 of of IN cord-005453-4057qib7 14256 10 death death NN cord-005453-4057qib7 14256 11 in in IN cord-005453-4057qib7 14256 12 4 4 CD cord-005453-4057qib7 14256 13 VOD VOD NNP cord-005453-4057qib7 14256 14 patients patient NNS cord-005453-4057qib7 14256 15 ( ( -LRB- cord-005453-4057qib7 14256 16 27 27 CD cord-005453-4057qib7 14256 17 % % NN cord-005453-4057qib7 14256 18 ) ) -RRB- cord-005453-4057qib7 14256 19 who who WP cord-005453-4057qib7 14256 20 died die VBD cord-005453-4057qib7 14256 21 . . . cord-005453-4057qib7 14257 1 Conclusions conclusion NNS cord-005453-4057qib7 14257 2 : : : cord-005453-4057qib7 14258 1 Despite despite IN cord-005453-4057qib7 14258 2 targeting target VBG cord-005453-4057qib7 14258 3 busulfan busulfan NN cord-005453-4057qib7 14258 4 levels level NNS cord-005453-4057qib7 14258 5 to to TO cord-005453-4057qib7 14258 6 decrease decrease VB cord-005453-4057qib7 14258 7 toxicity toxicity NN cord-005453-4057qib7 14258 8 of of IN cord-005453-4057qib7 14258 9 the the DT cord-005453-4057qib7 14258 10 regimen regimen NN cord-005453-4057qib7 14258 11 , , , cord-005453-4057qib7 14258 12 VOD VOD NNP cord-005453-4057qib7 14258 13 is be VBZ cord-005453-4057qib7 14258 14 common common JJ cord-005453-4057qib7 14259 1 ( ( -LRB- cord-005453-4057qib7 14259 2 we -PRON- PRP cord-005453-4057qib7 14259 3 observed observe VBD cord-005453-4057qib7 14259 4 VOD VOD NNP cord-005453-4057qib7 14259 5 incidence incidence NN cord-005453-4057qib7 14259 6 exactly exactly RB cord-005453-4057qib7 14259 7 in in IN cord-005453-4057qib7 14259 8 the the DT cord-005453-4057qib7 14259 9 range range NN cord-005453-4057qib7 14259 10 of of IN cord-005453-4057qib7 14259 11 the the DT cord-005453-4057qib7 14259 12 SIOPEN SIOPEN NNP cord-005453-4057qib7 14259 13 HR HR NNP cord-005453-4057qib7 14259 14 NBL-1 NBL-1 NNP cord-005453-4057qib7 14259 15 multicenter multicenter JJ cord-005453-4057qib7 14259 16 study study NN cord-005453-4057qib7 14259 17 ( ( -LRB- cord-005453-4057qib7 14259 18 Ladenstein Ladenstein NNP cord-005453-4057qib7 14259 19 , , , cord-005453-4057qib7 14259 20 2017 2017 CD cord-005453-4057qib7 14259 21 ) ) -RRB- cord-005453-4057qib7 14259 22 ) ) -RRB- cord-005453-4057qib7 14259 23 . . . cord-005453-4057qib7 14260 1 Early early JJ cord-005453-4057qib7 14260 2 recognition recognition NN cord-005453-4057qib7 14260 3 and and CC cord-005453-4057qib7 14260 4 early early JJ cord-005453-4057qib7 14260 5 treatment treatment NN cord-005453-4057qib7 14260 6 with with IN cord-005453-4057qib7 14260 7 defibrotide defibrotide NNP cord-005453-4057qib7 14260 8 seems seem VBZ cord-005453-4057qib7 14260 9 to to TO cord-005453-4057qib7 14260 10 be be VB cord-005453-4057qib7 14260 11 effective effective JJ cord-005453-4057qib7 14260 12 in in IN cord-005453-4057qib7 14260 13 VOD VOD NNP cord-005453-4057qib7 14260 14 associated associate VBN cord-005453-4057qib7 14260 15 with with IN cord-005453-4057qib7 14260 16 BuMel BuMel NNP cord-005453-4057qib7 14260 17 regimen regimen NN cord-005453-4057qib7 14260 18 -none -none CD cord-005453-4057qib7 14260 19 of of IN cord-005453-4057qib7 14260 20 our -PRON- PRP$ cord-005453-4057qib7 14260 21 15 15 CD cord-005453-4057qib7 14260 22 patients patient NNS cord-005453-4057qib7 14260 23 died die VBD cord-005453-4057qib7 14260 24 due due IN cord-005453-4057qib7 14260 25 to to IN cord-005453-4057qib7 14260 26 VOD VOD NNP cord-005453-4057qib7 14260 27 . . . cord-005453-4057qib7 14261 1 Disclosure disclosure NN cord-005453-4057qib7 14261 2 : : : cord-005453-4057qib7 14261 3 Nothing nothing NN cord-005453-4057qib7 14261 4 to to TO cord-005453-4057qib7 14261 5 declare declare VB cord-005453-4057qib7 14261 6 Results result NNS cord-005453-4057qib7 14261 7 of of IN cord-005453-4057qib7 14261 8 high high JJ cord-005453-4057qib7 14261 9 - - HYPH cord-005453-4057qib7 14261 10 dose dose NN cord-005453-4057qib7 14261 11 chemotherapy chemotherapy NN cord-005453-4057qib7 14261 12 ( ( -LRB- cord-005453-4057qib7 14261 13 HDCT HDCT NNP cord-005453-4057qib7 14261 14 ) ) -RRB- cord-005453-4057qib7 14261 15 with with IN cord-005453-4057qib7 14261 16 autologous autologous JJ cord-005453-4057qib7 14261 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 14261 18 stem stem NN cord-005453-4057qib7 14261 19 cell cell NN cord-005453-4057qib7 14261 20 transplantation transplantation NN cord-005453-4057qib7 14261 21 ( ( -LRB- cord-005453-4057qib7 14261 22 auto auto NN cord-005453-4057qib7 14261 23 - - HYPH cord-005453-4057qib7 14261 24 HSCT HSCT NNP cord-005453-4057qib7 14261 25 ) ) -RRB- cord-005453-4057qib7 14261 26 in in IN cord-005453-4057qib7 14261 27 the the DT cord-005453-4057qib7 14261 28 treatment treatment NN cord-005453-4057qib7 14261 29 of of IN cord-005453-4057qib7 14261 30 ewing ewing NNP cord-005453-4057qib7 14261 31 sarcoma sarcoma NNP cord-005453-4057qib7 14261 32 family family NN cord-005453-4057qib7 14261 33 tumors tumor NNS cord-005453-4057qib7 14261 34 ( ( -LRB- cord-005453-4057qib7 14261 35 ESFT ESFT NNP cord-005453-4057qib7 14261 36 ) ) -RRB- cord-005453-4057qib7 14262 1 Background background NN cord-005453-4057qib7 14262 2 : : : cord-005453-4057qib7 14262 3 While while IN cord-005453-4057qib7 14262 4 current current JJ cord-005453-4057qib7 14262 5 dose dose NN cord-005453-4057qib7 14262 6 - - HYPH cord-005453-4057qib7 14262 7 intense intense JJ cord-005453-4057qib7 14262 8 treatment treatment NN cord-005453-4057qib7 14262 9 protocols protocol NNS cord-005453-4057qib7 14262 10 allow allow VBP cord-005453-4057qib7 14262 11 achieving achieve VBG cord-005453-4057qib7 14262 12 70 70 CD cord-005453-4057qib7 14262 13 - - SYM cord-005453-4057qib7 14262 14 80 80 CD cord-005453-4057qib7 14262 15 % % NN cord-005453-4057qib7 14262 16 survival survival NN cord-005453-4057qib7 14262 17 in in IN cord-005453-4057qib7 14262 18 localized localized JJ cord-005453-4057qib7 14262 19 ESFT ESFT NNP cord-005453-4057qib7 14262 20 patients patient NNS cord-005453-4057qib7 14262 21 , , , cord-005453-4057qib7 14262 22 the the DT cord-005453-4057qib7 14262 23 long long JJ cord-005453-4057qib7 14262 24 - - HYPH cord-005453-4057qib7 14262 25 term term NN cord-005453-4057qib7 14262 26 survival survival NN cord-005453-4057qib7 14262 27 in in IN cord-005453-4057qib7 14262 28 high high JJ cord-005453-4057qib7 14262 29 - - HYPH cord-005453-4057qib7 14262 30 risk risk NN cord-005453-4057qib7 14262 31 cases case NNS cord-005453-4057qib7 14262 32 is be VBZ cord-005453-4057qib7 14262 33 still still RB cord-005453-4057qib7 14262 34 unsatisfactory unsatisfactory JJ cord-005453-4057qib7 14262 35 . . . cord-005453-4057qib7 14263 1 Although although IN cord-005453-4057qib7 14263 2 there there EX cord-005453-4057qib7 14263 3 is be VBZ cord-005453-4057qib7 14263 4 a a DT cord-005453-4057qib7 14263 5 considerable considerable JJ cord-005453-4057qib7 14263 6 body body NN cord-005453-4057qib7 14263 7 of of IN cord-005453-4057qib7 14263 8 data datum NNS cord-005453-4057qib7 14263 9 on on IN cord-005453-4057qib7 14263 10 high high JJ cord-005453-4057qib7 14263 11 - - HYPH cord-005453-4057qib7 14263 12 dose dose NN cord-005453-4057qib7 14263 13 consolidation consolidation NN cord-005453-4057qib7 14263 14 the the DT cord-005453-4057qib7 14263 15 real real JJ cord-005453-4057qib7 14263 16 effectiveness effectiveness NN cord-005453-4057qib7 14263 17 and and CC cord-005453-4057qib7 14263 18 optimal optimal JJ cord-005453-4057qib7 14263 19 indications indication NNS cord-005453-4057qib7 14263 20 for for IN cord-005453-4057qib7 14263 21 this this DT cord-005453-4057qib7 14263 22 option option NN cord-005453-4057qib7 14263 23 are be VBP cord-005453-4057qib7 14263 24 still still RB cord-005453-4057qib7 14263 25 not not RB cord-005453-4057qib7 14263 26 completely completely RB cord-005453-4057qib7 14263 27 clarified clarify VBN cord-005453-4057qib7 14263 28 . . . cord-005453-4057qib7 14264 1 Therefore therefore RB cord-005453-4057qib7 14264 2 , , , cord-005453-4057qib7 14264 3 a a DT cord-005453-4057qib7 14264 4 large large JJ cord-005453-4057qib7 14264 5 prospective prospective JJ cord-005453-4057qib7 14264 6 cohort cohort NN cord-005453-4057qib7 14264 7 analysis analysis NN cord-005453-4057qib7 14264 8 may may MD cord-005453-4057qib7 14264 9 still still RB cord-005453-4057qib7 14264 10 yield yield VB cord-005453-4057qib7 14264 11 useful useful JJ cord-005453-4057qib7 14264 12 data datum NNS cord-005453-4057qib7 14264 13 . . . cord-005453-4057qib7 14265 1 Methods method NNS cord-005453-4057qib7 14265 2 : : : cord-005453-4057qib7 14266 1 The the DT cord-005453-4057qib7 14266 2 whole whole JJ cord-005453-4057qib7 14266 3 cohort cohort NN cord-005453-4057qib7 14266 4 includes include VBZ cord-005453-4057qib7 14266 5 73 73 CD cord-005453-4057qib7 14266 6 consecutive consecutive JJ cord-005453-4057qib7 14266 7 highrisk highrisk JJ cord-005453-4057qib7 14266 8 ESFT ESFT NNP cord-005453-4057qib7 14266 9 patients patient NNS cord-005453-4057qib7 14266 10 with with IN cord-005453-4057qib7 14266 11 median median JJ cord-005453-4057qib7 14266 12 age age NN cord-005453-4057qib7 14266 13 of of IN cord-005453-4057qib7 14266 14 12 12 CD cord-005453-4057qib7 14267 1 ( ( -LRB- cord-005453-4057qib7 14267 2 range range NNP cord-005453-4057qib7 14267 3 1 1 CD cord-005453-4057qib7 14267 4 - - SYM cord-005453-4057qib7 14267 5 23 23 CD cord-005453-4057qib7 14267 6 ) ) -RRB- cord-005453-4057qib7 14267 7 years year NNS cord-005453-4057qib7 14267 8 receiving receive VBG cord-005453-4057qib7 14267 9 HDCT HDCT NNP cord-005453-4057qib7 14267 10 with with IN cord-005453-4057qib7 14267 11 auto auto NN cord-005453-4057qib7 14267 12 - - HYPH cord-005453-4057qib7 14267 13 HSCT HSCT NNP cord-005453-4057qib7 14267 14 in in IN cord-005453-4057qib7 14267 15 2007 2007 CD cord-005453-4057qib7 14267 16 to to IN cord-005453-4057qib7 14267 17 2018 2018 CD cord-005453-4057qib7 14267 18 after after IN cord-005453-4057qib7 14267 19 obtaining obtain VBG cord-005453-4057qib7 14267 20 1 1 CD cord-005453-4057qib7 14267 21 st st NNP cord-005453-4057qib7 14267 22 ( ( -LRB- cord-005453-4057qib7 14267 23 n=25 n=25 NNP cord-005453-4057qib7 14267 24 ) ) -RRB- cord-005453-4057qib7 14267 25 or or CC cord-005453-4057qib7 14267 26 2 2 CD cord-005453-4057qib7 14267 27 nd nd NNP cord-005453-4057qib7 14267 28 ( ( -LRB- cord-005453-4057qib7 14267 29 n=3 n=3 NN cord-005453-4057qib7 14267 30 ) ) -RRB- cord-005453-4057qib7 14267 31 CR CR NNP cord-005453-4057qib7 14267 32 , , , cord-005453-4057qib7 14267 33 PR PR NNP cord-005453-4057qib7 14267 34 ( ( -LRB- cord-005453-4057qib7 14267 35 n=35 n=35 NNP cord-005453-4057qib7 14267 36 ) ) -RRB- cord-005453-4057qib7 14267 37 , , , cord-005453-4057qib7 14267 38 or or CC cord-005453-4057qib7 14267 39 stable stable JJ cord-005453-4057qib7 14267 40 disease disease NN cord-005453-4057qib7 14267 41 ( ( -LRB- cord-005453-4057qib7 14267 42 n=10 n=10 NNP cord-005453-4057qib7 14267 43 ) ) -RRB- cord-005453-4057qib7 14267 44 . . . cord-005453-4057qib7 14268 1 The the DT cord-005453-4057qib7 14268 2 high high JJ cord-005453-4057qib7 14268 3 - - HYPH cord-005453-4057qib7 14268 4 risk risk NN cord-005453-4057qib7 14268 5 features feature NNS cord-005453-4057qib7 14268 6 included include VBN cord-005453-4057qib7 14268 7 lung lung NN cord-005453-4057qib7 14268 8 ( ( -LRB- cord-005453-4057qib7 14268 9 n=52 n=52 NN cord-005453-4057qib7 14268 10 ) ) -RRB- cord-005453-4057qib7 14268 11 , , , cord-005453-4057qib7 14268 12 bone bone NN cord-005453-4057qib7 14268 13 ( ( -LRB- cord-005453-4057qib7 14268 14 n=25 n=25 NNP cord-005453-4057qib7 14268 15 ) ) -RRB- cord-005453-4057qib7 14268 16 or or CC cord-005453-4057qib7 14268 17 bone bone NN cord-005453-4057qib7 14268 18 marrow marrow NN cord-005453-4057qib7 14268 19 ( ( -LRB- cord-005453-4057qib7 14268 20 n=11 n=11 NNP cord-005453-4057qib7 14268 21 ) ) -RRB- cord-005453-4057qib7 14268 22 involvement involvement NN cord-005453-4057qib7 14268 23 , , , cord-005453-4057qib7 14268 24 inadequate inadequate JJ cord-005453-4057qib7 14268 25 local local JJ cord-005453-4057qib7 14268 26 control control NN cord-005453-4057qib7 14268 27 in in IN cord-005453-4057qib7 14268 28 primary primary JJ cord-005453-4057qib7 14268 29 axial axial JJ cord-005453-4057qib7 14268 30 tumors tumor NNS cord-005453-4057qib7 14268 31 ( ( -LRB- cord-005453-4057qib7 14268 32 n=52 n=52 NN cord-005453-4057qib7 14268 33 ) ) -RRB- cord-005453-4057qib7 14268 34 , , , cord-005453-4057qib7 14268 35 large large JJ cord-005453-4057qib7 14268 36 lesions lesion NNS cord-005453-4057qib7 14268 37 volume volume NN cord-005453-4057qib7 14268 38 or or CC cord-005453-4057qib7 14268 39 poor poor JJ cord-005453-4057qib7 14268 40 treatment treatment NN cord-005453-4057qib7 14268 41 response response NN cord-005453-4057qib7 14268 42 ( ( -LRB- cord-005453-4057qib7 14268 43 n=52 n=52 NN cord-005453-4057qib7 14268 44 ) ) -RRB- cord-005453-4057qib7 14268 45 , , , cord-005453-4057qib7 14268 46 and and CC cord-005453-4057qib7 14268 47 chemosensitive chemosensitive JJ cord-005453-4057qib7 14268 48 relapse relapse NN cord-005453-4057qib7 14268 49 ( ( -LRB- cord-005453-4057qib7 14268 50 n=9 n=9 NN cord-005453-4057qib7 14268 51 ) ) -RRB- cord-005453-4057qib7 14268 52 . . . cord-005453-4057qib7 14269 1 Most Most JJS cord-005453-4057qib7 14269 2 patients patient NNS cord-005453-4057qib7 14269 3 had have VBD cord-005453-4057qib7 14269 4 several several JJ cord-005453-4057qib7 14269 5 risk risk NN cord-005453-4057qib7 14269 6 factors factor NNS cord-005453-4057qib7 14269 7 . . . cord-005453-4057qib7 14270 1 Disseminated disseminate VBN cord-005453-4057qib7 14270 2 disease disease NN cord-005453-4057qib7 14270 3 patients patient NNS cord-005453-4057qib7 14270 4 were be VBD cord-005453-4057qib7 14270 5 also also RB cord-005453-4057qib7 14270 6 evaluated evaluate VBN cord-005453-4057qib7 14270 7 according accord VBG cord-005453-4057qib7 14270 8 to to IN cord-005453-4057qib7 14270 9 prognostic prognostic JJ cord-005453-4057qib7 14270 10 score score NN cord-005453-4057qib7 14270 11 by by IN cord-005453-4057qib7 14270 12 R.Ladenstein R.Ladenstein NNP cord-005453-4057qib7 14270 13 et et FW cord-005453-4057qib7 14270 14 al al NNP cord-005453-4057qib7 14270 15 . . . cord-005453-4057qib7 14271 1 Highdose Highdose NNP cord-005453-4057qib7 14271 2 busulfan busulfan NN cord-005453-4057qib7 14271 3 - - HYPH cord-005453-4057qib7 14271 4 melphalan melphalan NNP cord-005453-4057qib7 14271 5 followed follow VBN cord-005453-4057qib7 14271 6 by by IN cord-005453-4057qib7 14271 7 autologous autologous JJ cord-005453-4057qib7 14271 8 stem stem NN cord-005453-4057qib7 14271 9 - - HYPH cord-005453-4057qib7 14271 10 cell cell NN cord-005453-4057qib7 14271 11 transplantation transplantation NN cord-005453-4057qib7 14271 12 ( ( -LRB- cord-005453-4057qib7 14271 13 HDT HDT NNP cord-005453-4057qib7 14271 14 / / SYM cord-005453-4057qib7 14271 15 SCT SCT NNP cord-005453-4057qib7 14271 16 ) ) -RRB- cord-005453-4057qib7 14271 17 was be VBD cord-005453-4057qib7 14271 18 used use VBN cord-005453-4057qib7 14271 19 . . . cord-005453-4057qib7 14272 1 Results result NNS cord-005453-4057qib7 14272 2 : : : cord-005453-4057qib7 14273 1 The the DT cord-005453-4057qib7 14273 2 median median JJ cord-005453-4057qib7 14273 3 observation observation NN cord-005453-4057qib7 14273 4 time time NN cord-005453-4057qib7 14273 5 was be VBD cord-005453-4057qib7 14273 6 60 60 CD cord-005453-4057qib7 14274 1 ( ( -LRB- cord-005453-4057qib7 14274 2 range range NNP cord-005453-4057qib7 14274 3 3 3 CD cord-005453-4057qib7 14274 4 - - SYM cord-005453-4057qib7 14274 5 130 130 CD cord-005453-4057qib7 14274 6 ) ) -RRB- cord-005453-4057qib7 14274 7 months month NNS cord-005453-4057qib7 14274 8 . . . cord-005453-4057qib7 14275 1 The the DT cord-005453-4057qib7 14275 2 5-year 5-year CD cord-005453-4057qib7 14275 3 overall overall NN cord-005453-4057qib7 14275 4 ( ( -LRB- cord-005453-4057qib7 14275 5 OS OS NNP cord-005453-4057qib7 14275 6 ) ) -RRB- cord-005453-4057qib7 14275 7 and and CC cord-005453-4057qib7 14275 8 event event NN cord-005453-4057qib7 14275 9 - - HYPH cord-005453-4057qib7 14275 10 free free JJ cord-005453-4057qib7 14275 11 ( ( -LRB- cord-005453-4057qib7 14275 12 EFS efs NN cord-005453-4057qib7 14275 13 ) ) -RRB- cord-005453-4057qib7 14275 14 survival survival NN cord-005453-4057qib7 14275 15 were be VBD cord-005453-4057qib7 14275 16 40 40 CD cord-005453-4057qib7 14275 17 % % NN cord-005453-4057qib7 14275 18 and and CC cord-005453-4057qib7 14275 19 37 37 CD cord-005453-4057qib7 14275 20 % % NN cord-005453-4057qib7 14275 21 , , , cord-005453-4057qib7 14275 22 accordingly accordingly RB cord-005453-4057qib7 14275 23 . . . cord-005453-4057qib7 14276 1 Most most RBS cord-005453-4057qib7 14276 2 important important JJ cord-005453-4057qib7 14276 3 outcome outcome NN cord-005453-4057qib7 14276 4 predictors predictor NNS cord-005453-4057qib7 14276 5 were be VBD cord-005453-4057qib7 14276 6 inadequate inadequate JJ cord-005453-4057qib7 14276 7 local local JJ cord-005453-4057qib7 14276 8 control control NN cord-005453-4057qib7 14276 9 in in IN cord-005453-4057qib7 14276 10 chemoresistant chemoresistant JJ cord-005453-4057qib7 14276 11 cases case NNS cord-005453-4057qib7 14276 12 , , , cord-005453-4057qib7 14276 13 a a DT cord-005453-4057qib7 14276 14 primary primary JJ cord-005453-4057qib7 14276 15 tumor tumor NN cord-005453-4057qib7 14276 16 volume volume NN cord-005453-4057qib7 14277 1 more more JJR cord-005453-4057qib7 14277 2 than than IN cord-005453-4057qib7 14277 3 200 200 CD cord-005453-4057qib7 14277 4 mL ml NN cord-005453-4057qib7 14277 5 , , , cord-005453-4057qib7 14277 6 more more JJR cord-005453-4057qib7 14277 7 than than IN cord-005453-4057qib7 14277 8 one one CD cord-005453-4057qib7 14277 9 bone bone NN cord-005453-4057qib7 14277 10 metastatic metastatic JJ cord-005453-4057qib7 14277 11 site site NN cord-005453-4057qib7 14277 12 , , , cord-005453-4057qib7 14277 13 bone bone NN cord-005453-4057qib7 14277 14 marrow marrow NN cord-005453-4057qib7 14277 15 involvement involvement NN cord-005453-4057qib7 14277 16 and and CC cord-005453-4057qib7 14277 17 additional additional JJ cord-005453-4057qib7 14277 18 lung lung NN cord-005453-4057qib7 14277 19 metastases metastasis NNS cord-005453-4057qib7 14277 20 . . . cord-005453-4057qib7 14278 1 According accord VBG cord-005453-4057qib7 14278 2 to to IN cord-005453-4057qib7 14278 3 prognostic prognostic JJ cord-005453-4057qib7 14278 4 risk risk NN cord-005453-4057qib7 14278 5 score score NN cord-005453-4057qib7 14278 6 in in IN cord-005453-4057qib7 14278 7 disseminated disseminate VBN cord-005453-4057qib7 14278 8 disease disease NN cord-005453-4057qib7 14278 9 ESFT ESFT NNP cord-005453-4057qib7 14278 10 patients patient NNS cord-005453-4057qib7 14278 11 identified identify VBD cord-005453-4057qib7 14278 12 three three CD cord-005453-4057qib7 14278 13 groups group NNS cord-005453-4057qib7 14278 14 with with IN cord-005453-4057qib7 14278 15 5-year 5-year CD cord-005453-4057qib7 14278 16 OS OS NNP cord-005453-4057qib7 14278 17 rates rate NNS cord-005453-4057qib7 14278 18 of of IN cord-005453-4057qib7 14278 19 49 49 CD cord-005453-4057qib7 14278 20 % % NN cord-005453-4057qib7 14278 21 for for IN cord-005453-4057qib7 14278 22 score score NN cord-005453-4057qib7 14278 23 ≤3 ≤3 NNPS cord-005453-4057qib7 14278 24 ( ( -LRB- cord-005453-4057qib7 14278 25 19 19 CD cord-005453-4057qib7 14278 26 patients patient NNS cord-005453-4057qib7 14278 27 ) ) -RRB- cord-005453-4057qib7 14278 28 , , , cord-005453-4057qib7 14278 29 36 36 CD cord-005453-4057qib7 14278 30 % % NN cord-005453-4057qib7 14278 31 for for IN cord-005453-4057qib7 14278 32 score score NN cord-005453-4057qib7 14278 33 3 3 CD cord-005453-4057qib7 14278 34 to to IN cord-005453-4057qib7 14278 35 5 5 CD cord-005453-4057qib7 14278 36 ( ( -LRB- cord-005453-4057qib7 14278 37 27 27 CD cord-005453-4057qib7 14278 38 patients patient NNS cord-005453-4057qib7 14278 39 ) ) -RRB- cord-005453-4057qib7 14278 40 , , , cord-005453-4057qib7 14278 41 and and CC cord-005453-4057qib7 14278 42 8 8 CD cord-005453-4057qib7 14278 43 % % NN cord-005453-4057qib7 14278 44 for for IN cord-005453-4057qib7 14278 45 score score NN cord-005453-4057qib7 14278 46 ≥5 ≥5 NNPS cord-005453-4057qib7 14278 47 ( ( -LRB- cord-005453-4057qib7 14278 48 12 12 CD cord-005453-4057qib7 14278 49 patients patient NNS cord-005453-4057qib7 14278 50 ) ) -RRB- cord-005453-4057qib7 14278 51 , , , cord-005453-4057qib7 14278 52 ( ( -LRB- cord-005453-4057qib7 14278 53 P p NN cord-005453-4057qib7 14278 54 < < XX cord-005453-4057qib7 14278 55 0.01 0.01 CD cord-005453-4057qib7 14278 56 ) ) -RRB- cord-005453-4057qib7 14278 57 . . . cord-005453-4057qib7 14279 1 Conclusions conclusion NNS cord-005453-4057qib7 14279 2 : : : cord-005453-4057qib7 14280 1 While while IN cord-005453-4057qib7 14280 2 Bu Bu NNP cord-005453-4057qib7 14280 3 - - HYPH cord-005453-4057qib7 14280 4 Mel Mel NNP cord-005453-4057qib7 14280 5 HDCT HDCT NNP cord-005453-4057qib7 14280 6 with with IN cord-005453-4057qib7 14280 7 auto auto NN cord-005453-4057qib7 14280 8 - - HYPH cord-005453-4057qib7 14280 9 HSCT HSCT NNP cord-005453-4057qib7 14280 10 may may MD cord-005453-4057qib7 14280 11 still still RB cord-005453-4057qib7 14280 12 be be VB cord-005453-4057qib7 14280 13 a a DT cord-005453-4057qib7 14280 14 feasible feasible JJ cord-005453-4057qib7 14280 15 option option NN cord-005453-4057qib7 14280 16 with with IN cord-005453-4057qib7 14280 17 acceptable acceptable JJ cord-005453-4057qib7 14280 18 toxicity toxicity NN cord-005453-4057qib7 14280 19 for for IN cord-005453-4057qib7 14280 20 chemosensitive chemosensitive JJ cord-005453-4057qib7 14280 21 patients patient NNS cord-005453-4057qib7 14280 22 with with IN cord-005453-4057qib7 14280 23 inadequate inadequate JJ cord-005453-4057qib7 14280 24 local local JJ cord-005453-4057qib7 14280 25 control control NN cord-005453-4057qib7 14280 26 and and CC cord-005453-4057qib7 14280 27 some some DT cord-005453-4057qib7 14280 28 primarily primarily RB cord-005453-4057qib7 14280 29 disseminated disseminate VBN cord-005453-4057qib7 14280 30 cases case NNS cord-005453-4057qib7 14280 31 it -PRON- PRP cord-005453-4057qib7 14280 32 is be VBZ cord-005453-4057qib7 14280 33 ineffective ineffective JJ cord-005453-4057qib7 14280 34 in in IN cord-005453-4057qib7 14280 35 primary primary JJ cord-005453-4057qib7 14280 36 resistant resistant JJ cord-005453-4057qib7 14280 37 or or CC cord-005453-4057qib7 14280 38 very very RB cord-005453-4057qib7 14280 39 high high JJ cord-005453-4057qib7 14280 40 - - HYPH cord-005453-4057qib7 14280 41 risk risk NN cord-005453-4057qib7 14280 42 metastatic metastatic JJ cord-005453-4057qib7 14280 43 patients patient NNS cord-005453-4057qib7 14280 44 . . . cord-005453-4057qib7 14281 1 Disclosure disclosure NN cord-005453-4057qib7 14281 2 : : : cord-005453-4057qib7 14281 3 Nothing nothing NN cord-005453-4057qib7 14281 4 to to TO cord-005453-4057qib7 14281 5 declare declare VB cord-005453-4057qib7 14281 6 Efficacy Efficacy NNP cord-005453-4057qib7 14281 7 of of IN cord-005453-4057qib7 14281 8 tandem tandem JJ cord-005453-4057qib7 14281 9 high high JJ cord-005453-4057qib7 14281 10 - - HYPH cord-005453-4057qib7 14281 11 dose dose NN cord-005453-4057qib7 14281 12 chemotherapy chemotherapy NN cord-005453-4057qib7 14281 13 with with IN cord-005453-4057qib7 14281 14 autologous autologous JJ cord-005453-4057qib7 14281 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 14281 16 stem stem NN cord-005453-4057qib7 14281 17 cell cell NN cord-005453-4057qib7 14281 18 transplantation transplantation NN cord-005453-4057qib7 14281 19 in in IN cord-005453-4057qib7 14281 20 the the DT cord-005453-4057qib7 14281 21 treatment treatment NN cord-005453-4057qib7 14281 22 of of IN cord-005453-4057qib7 14281 23 infant infant NN cord-005453-4057qib7 14281 24 embryonal embryonal JJ cord-005453-4057qib7 14281 25 brain brain NN cord-005453-4057qib7 14281 26 tumors tumor NNS cord-005453-4057qib7 14281 27 day day NN cord-005453-4057qib7 14281 28 +15 +15 CD cord-005453-4057qib7 14281 29 ( ( -LRB- cord-005453-4057qib7 14281 30 range range NN cord-005453-4057qib7 14281 31 , , , cord-005453-4057qib7 14281 32 8 8 CD cord-005453-4057qib7 14281 33 - - SYM cord-005453-4057qib7 14281 34 83 83 CD cord-005453-4057qib7 14281 35 ) ) -RRB- cord-005453-4057qib7 14281 36 , , , cord-005453-4057qib7 14281 37 after after IN cord-005453-4057qib7 14281 38 the the DT cord-005453-4057qib7 14281 39 second second JJ cord-005453-4057qib7 14281 40 auto auto NN cord-005453-4057qib7 14281 41 - - HYPH cord-005453-4057qib7 14281 42 HSCT HSCT NNP cord-005453-4057qib7 14281 43 was be VBD cord-005453-4057qib7 14281 44 day day NN cord-005453-4057qib7 14281 45 +17 +17 CD cord-005453-4057qib7 14282 1 ( ( -LRB- cord-005453-4057qib7 14282 2 range range NN cord-005453-4057qib7 14282 3 , , , cord-005453-4057qib7 14282 4 9 9 CD cord-005453-4057qib7 14282 5 - - SYM cord-005453-4057qib7 14282 6 86 86 CD cord-005453-4057qib7 14282 7 ) ) -RRB- cord-005453-4057qib7 14282 8 . . . cord-005453-4057qib7 14283 1 Two two CD cord-005453-4057qib7 14283 2 - - HYPH cord-005453-4057qib7 14283 3 year year NN cord-005453-4057qib7 14283 4 overall overall JJ cord-005453-4057qib7 14283 5 survival survival NN cord-005453-4057qib7 14283 6 ( ( -LRB- cord-005453-4057qib7 14283 7 OS OS NNP cord-005453-4057qib7 14283 8 ) ) -RRB- cord-005453-4057qib7 14283 9 was be VBD cord-005453-4057qib7 14283 10 76 76 CD cord-005453-4057qib7 14283 11 % % NN cord-005453-4057qib7 14283 12 and and CC cord-005453-4057qib7 14283 13 disease disease NN cord-005453-4057qib7 14283 14 free free JJ cord-005453-4057qib7 14283 15 survival survival NN cord-005453-4057qib7 14283 16 ( ( -LRB- cord-005453-4057qib7 14283 17 DFS DFS NNP cord-005453-4057qib7 14283 18 ) ) -RRB- cord-005453-4057qib7 14283 19 was be VBD cord-005453-4057qib7 14283 20 68 68 CD cord-005453-4057qib7 14283 21 % % NN cord-005453-4057qib7 14283 22 . . . cord-005453-4057qib7 14284 1 DFS DFS NNP cord-005453-4057qib7 14284 2 was be VBD cord-005453-4057qib7 14284 3 significantly significantly RB cord-005453-4057qib7 14284 4 better well JJR cord-005453-4057qib7 14284 5 among among IN cord-005453-4057qib7 14284 6 patients patient NNS cord-005453-4057qib7 14284 7 with with IN cord-005453-4057qib7 14284 8 MB MB NNP cord-005453-4057qib7 14284 9 ( ( -LRB- cord-005453-4057qib7 14284 10 95 95 CD cord-005453-4057qib7 14284 11 % % NN cord-005453-4057qib7 14284 12 ) ) -RRB- cord-005453-4057qib7 14284 13 and and CC cord-005453-4057qib7 14284 14 PNET PNET NNP cord-005453-4057qib7 14284 15 ( ( -LRB- cord-005453-4057qib7 14284 16 75 75 CD cord-005453-4057qib7 14284 17 % % NN cord-005453-4057qib7 14284 18 ) ) -RRB- cord-005453-4057qib7 14284 19 in in IN cord-005453-4057qib7 14284 20 compared compare VBN cord-005453-4057qib7 14284 21 to to IN cord-005453-4057qib7 14284 22 children child NNS cord-005453-4057qib7 14284 23 with with IN cord-005453-4057qib7 14284 24 ETMR ETMR NNP cord-005453-4057qib7 14284 25 ( ( -LRB- cord-005453-4057qib7 14284 26 55 55 CD cord-005453-4057qib7 14284 27 % % NN cord-005453-4057qib7 14284 28 ) ) -RRB- cord-005453-4057qib7 14284 29 , , , cord-005453-4057qib7 14284 30 PB PB NNP cord-005453-4057qib7 14284 31 ( ( -LRB- cord-005453-4057qib7 14284 32 33 33 CD cord-005453-4057qib7 14284 33 % % NN cord-005453-4057qib7 14284 34 ) ) -RRB- cord-005453-4057qib7 14284 35 and and CC cord-005453-4057qib7 14284 36 ATRT ATRT NNP cord-005453-4057qib7 14284 37 ( ( -LRB- cord-005453-4057qib7 14284 38 0 0 CD cord-005453-4057qib7 14284 39 % % NN cord-005453-4057qib7 14284 40 ) ) -RRB- cord-005453-4057qib7 14284 41 , , , cord-005453-4057qib7 14284 42 ( ( -LRB- cord-005453-4057qib7 14284 43 p=0,01 p=0,01 NN cord-005453-4057qib7 14284 44 ) ) -RRB- cord-005453-4057qib7 14284 45 . . . cord-005453-4057qib7 14285 1 DFS DFS NNP cord-005453-4057qib7 14285 2 in in IN cord-005453-4057qib7 14285 3 patients patient NNS cord-005453-4057qib7 14285 4 who who WP cord-005453-4057qib7 14285 5 received receive VBD cord-005453-4057qib7 14285 6 tandem tandem JJ cord-005453-4057qib7 14285 7 auto auto NN cord-005453-4057qib7 14285 8 - - HYPH cord-005453-4057qib7 14285 9 HSCT HSCT NNP cord-005453-4057qib7 14285 10 was be VBD cord-005453-4057qib7 14285 11 75 75 CD cord-005453-4057qib7 14285 12 % % NN cord-005453-4057qib7 14285 13 in in IN cord-005453-4057qib7 14285 14 compare compare NN cord-005453-4057qib7 14285 15 to to IN cord-005453-4057qib7 14285 16 infants infant NNS cord-005453-4057qib7 14285 17 who who WP cord-005453-4057qib7 14285 18 received receive VBD cord-005453-4057qib7 14285 19 only only RB cord-005453-4057qib7 14285 20 one one CD cord-005453-4057qib7 14285 21 auto auto NN cord-005453-4057qib7 14285 22 - - HYPH cord-005453-4057qib7 14285 23 HSCT HSCT NNP cord-005453-4057qib7 14285 24 ( ( -LRB- cord-005453-4057qib7 14285 25 44 44 CD cord-005453-4057qib7 14285 26 % % NN cord-005453-4057qib7 14285 27 ) ) -RRB- cord-005453-4057qib7 14285 28 , , , cord-005453-4057qib7 14285 29 ( ( -LRB- cord-005453-4057qib7 14285 30 p=0,000 p=0,000 NNP cord-005453-4057qib7 14285 31 ) ) -RRB- cord-005453-4057qib7 14285 32 . . . cord-005453-4057qib7 14286 1 Complications complication NNS cord-005453-4057qib7 14286 2 grade grade NN cord-005453-4057qib7 14286 3 4 4 CD cord-005453-4057qib7 14286 4 ( ( -LRB- cord-005453-4057qib7 14286 5 according accord VBG cord-005453-4057qib7 14286 6 to to IN cord-005453-4057qib7 14286 7 COMMON common JJ cord-005453-4057qib7 14286 8 TOXICITY toxicity NN cord-005453-4057qib7 14286 9 CRITERIA criterion NNS cord-005453-4057qib7 14286 10 2014 2014 CD cord-005453-4057qib7 14286 11 ) ) -RRB- cord-005453-4057qib7 14286 12 were be VBD cord-005453-4057qib7 14286 13 observed observe VBN cord-005453-4057qib7 14286 14 in in IN cord-005453-4057qib7 14286 15 14 14 CD cord-005453-4057qib7 14286 16 % % NN cord-005453-4057qib7 14286 17 of of IN cord-005453-4057qib7 14286 18 cases case NNS cord-005453-4057qib7 14286 19 . . . cord-005453-4057qib7 14287 1 Conclusions conclusion NNS cord-005453-4057qib7 14287 2 : : : cord-005453-4057qib7 14288 1 Employment employment NN cord-005453-4057qib7 14288 2 of of IN cord-005453-4057qib7 14288 3 tandem tandem JJ cord-005453-4057qib7 14288 4 HDCT HDCT NNP cord-005453-4057qib7 14288 5 with with IN cord-005453-4057qib7 14288 6 auto auto NN cord-005453-4057qib7 14288 7 - - HYPH cord-005453-4057qib7 14288 8 HSCT HSCT NNP cord-005453-4057qib7 14288 9 in in IN cord-005453-4057qib7 14288 10 primary primary JJ cord-005453-4057qib7 14288 11 infant infant NN cord-005453-4057qib7 14288 12 embryonal embryonal JJ cord-005453-4057qib7 14288 13 brain brain NN cord-005453-4057qib7 14288 14 tumors tumor NNS cord-005453-4057qib7 14288 15 may may MD cord-005453-4057qib7 14288 16 be be VB cord-005453-4057qib7 14288 17 a a DT cord-005453-4057qib7 14288 18 feasible feasible JJ cord-005453-4057qib7 14288 19 option option NN cord-005453-4057qib7 14288 20 for for IN cord-005453-4057qib7 14288 21 patients patient NNS cord-005453-4057qib7 14288 22 after after IN cord-005453-4057qib7 14288 23 induction induction NN cord-005453-4057qib7 14288 24 treatment treatment NN cord-005453-4057qib7 14288 25 . . . cord-005453-4057qib7 14289 1 Both both DT cord-005453-4057qib7 14289 2 conditioning conditioning NN cord-005453-4057qib7 14289 3 regimens regimen NNS cord-005453-4057qib7 14289 4 had have VBD cord-005453-4057qib7 14289 5 acceptable acceptable JJ cord-005453-4057qib7 14289 6 toxicity toxicity NN cord-005453-4057qib7 14289 7 . . . cord-005453-4057qib7 14290 1 All all DT cord-005453-4057qib7 14290 2 patients patient NNS cord-005453-4057qib7 14290 3 who who WP cord-005453-4057qib7 14290 4 had have VBD cord-005453-4057qib7 14290 5 tandem tandem JJ cord-005453-4057qib7 14290 6 HDCT HDCT NNP cord-005453-4057qib7 14290 7 with with IN cord-005453-4057qib7 14290 8 auto auto NN cord-005453-4057qib7 14290 9 - - HYPH cord-005453-4057qib7 14290 10 HSCT HSCT NNP cord-005453-4057qib7 14290 11 had have VBD cord-005453-4057qib7 14290 12 better well JJR cord-005453-4057qib7 14290 13 OS OS NNP cord-005453-4057qib7 14290 14 ( ( -LRB- cord-005453-4057qib7 14290 15 75 75 CD cord-005453-4057qib7 14290 16 % % NN cord-005453-4057qib7 14290 17 ) ) -RRB- cord-005453-4057qib7 14290 18 in in IN cord-005453-4057qib7 14290 19 compare compare NN cord-005453-4057qib7 14290 20 with with IN cord-005453-4057qib7 14290 21 single single JJ cord-005453-4057qib7 14290 22 HDCT HDCT NNP cord-005453-4057qib7 14290 23 ( ( -LRB- cord-005453-4057qib7 14290 24 44 44 CD cord-005453-4057qib7 14290 25 % % NN cord-005453-4057qib7 14290 26 ) ) -RRB- cord-005453-4057qib7 14290 27 . . . cord-005453-4057qib7 14291 1 Patients patient NNS cord-005453-4057qib7 14291 2 with with IN cord-005453-4057qib7 14291 3 MB mb NN cord-005453-4057qib7 14291 4 and and CC cord-005453-4057qib7 14291 5 PNET PNET NNP cord-005453-4057qib7 14291 6 had have VBD cord-005453-4057qib7 14291 7 better well JJR cord-005453-4057qib7 14291 8 prognosis prognosis NN cord-005453-4057qib7 14291 9 with with IN cord-005453-4057qib7 14291 10 OS OS NNP cord-005453-4057qib7 14291 11 95 95 CD cord-005453-4057qib7 14291 12 % % NN cord-005453-4057qib7 14291 13 and and CC cord-005453-4057qib7 14291 14 75 75 CD cord-005453-4057qib7 14291 15 % % NN cord-005453-4057qib7 14291 16 , , , cord-005453-4057qib7 14291 17 respectively respectively RB cord-005453-4057qib7 14291 18 , , , cord-005453-4057qib7 14291 19 in in IN cord-005453-4057qib7 14291 20 compare compare NN cord-005453-4057qib7 14291 21 with with IN cord-005453-4057qib7 14291 22 other other JJ cord-005453-4057qib7 14291 23 embryonal embryonal JJ cord-005453-4057qib7 14291 24 tumors tumor NNS cord-005453-4057qib7 14291 25 . . . cord-005453-4057qib7 14292 1 Disclosure disclosure NN cord-005453-4057qib7 14292 2 : : : cord-005453-4057qib7 14292 3 Nothing nothing NN cord-005453-4057qib7 14292 4 to to TO cord-005453-4057qib7 14292 5 declare declare VB cord-005453-4057qib7 14292 6 Background background NN cord-005453-4057qib7 14292 7 : : : cord-005453-4057qib7 14293 1 Metastatic metastatic JJ cord-005453-4057qib7 14293 2 extra extra JJ cord-005453-4057qib7 14293 3 ocular ocular JJ cord-005453-4057qib7 14293 4 retinoblastoma retinoblastoma NN cord-005453-4057qib7 14293 5 is be VBZ cord-005453-4057qib7 14293 6 carrying carry VBG cord-005453-4057qib7 14293 7 a a DT cord-005453-4057qib7 14293 8 poor poor JJ cord-005453-4057qib7 14293 9 prognosis prognosis NN cord-005453-4057qib7 14293 10 . . . cord-005453-4057qib7 14294 1 Therapeutic therapeutic JJ cord-005453-4057qib7 14294 2 intensification intensification NN cord-005453-4057qib7 14294 3 with with IN cord-005453-4057qib7 14294 4 high high JJ cord-005453-4057qib7 14294 5 - - HYPH cord-005453-4057qib7 14294 6 dose dose NN cord-005453-4057qib7 14294 7 , , , cord-005453-4057qib7 14294 8 marrow marrow NN cord-005453-4057qib7 14294 9 - - HYPH cord-005453-4057qib7 14294 10 ablative ablative NN cord-005453-4057qib7 14294 11 chemotherapy chemotherapy NN cord-005453-4057qib7 14294 12 and and CC cord-005453-4057qib7 14294 13 autologous autologous JJ cord-005453-4057qib7 14294 14 HSCT HSCT NNP cord-005453-4057qib7 14294 15 has have VBZ cord-005453-4057qib7 14294 16 been be VBN cord-005453-4057qib7 14294 17 explored explore VBN cord-005453-4057qib7 14294 18 , , , cord-005453-4057qib7 14294 19 but but CC cord-005453-4057qib7 14294 20 its -PRON- PRP$ cord-005453-4057qib7 14294 21 role role NN cord-005453-4057qib7 14294 22 is be VBZ cord-005453-4057qib7 14294 23 not not RB cord-005453-4057qib7 14294 24 yet yet RB cord-005453-4057qib7 14294 25 clear clear JJ cord-005453-4057qib7 14294 26 . . . cord-005453-4057qib7 14295 1 This this DT cord-005453-4057qib7 14295 2 study study NN cord-005453-4057qib7 14295 3 aimed aim VBD cord-005453-4057qib7 14295 4 to to TO cord-005453-4057qib7 14295 5 evaluate evaluate VB cord-005453-4057qib7 14295 6 the the DT cord-005453-4057qib7 14295 7 survival survival NN cord-005453-4057qib7 14295 8 outcome outcome NN cord-005453-4057qib7 14295 9 of of IN cord-005453-4057qib7 14295 10 patients patient NNS cord-005453-4057qib7 14295 11 with with IN cord-005453-4057qib7 14295 12 extraocular extraocular JJ cord-005453-4057qib7 14295 13 retinoblastoma retinoblastoma NN cord-005453-4057qib7 14295 14 post post NN cord-005453-4057qib7 14295 15 autologous autologous JJ cord-005453-4057qib7 14295 16 stem stem NN cord-005453-4057qib7 14295 17 cell cell NN cord-005453-4057qib7 14295 18 transplant transplant NN cord-005453-4057qib7 14295 19 , , , cord-005453-4057qib7 14295 20 treated treat VBN cord-005453-4057qib7 14295 21 at at IN cord-005453-4057qib7 14295 22 single single JJ cord-005453-4057qib7 14295 23 center center NN cord-005453-4057qib7 14295 24 Methods method NNS cord-005453-4057qib7 14295 25 : : : cord-005453-4057qib7 14295 26 This this DT cord-005453-4057qib7 14295 27 is be VBZ cord-005453-4057qib7 14295 28 a a DT cord-005453-4057qib7 14295 29 retrospective retrospective JJ cord-005453-4057qib7 14295 30 study study NN cord-005453-4057qib7 14295 31 included include VBD cord-005453-4057qib7 14295 32 all all DT cord-005453-4057qib7 14295 33 patients patient NNS cord-005453-4057qib7 14295 34 with with IN cord-005453-4057qib7 14295 35 metastatic metastatic JJ cord-005453-4057qib7 14295 36 extraocular extraocular JJ cord-005453-4057qib7 14295 37 retinoblastoma retinoblastoma NN cord-005453-4057qib7 14295 38 ( ( -LRB- cord-005453-4057qib7 14295 39 stages stage NNS cord-005453-4057qib7 14295 40 4a 4a CD cord-005453-4057qib7 14295 41 and and CC cord-005453-4057qib7 14295 42 4b 4b LS cord-005453-4057qib7 14295 43 ) ) -RRB- cord-005453-4057qib7 14295 44 that that WDT cord-005453-4057qib7 14295 45 underwent undergo VBD cord-005453-4057qib7 14295 46 autologous autologous JJ cord-005453-4057qib7 14295 47 HSCT HSCT NNP cord-005453-4057qib7 14295 48 at at IN cord-005453-4057qib7 14295 49 the the DT cord-005453-4057qib7 14295 50 Children Children NNP cord-005453-4057qib7 14295 51 Cancer Cancer NNP cord-005453-4057qib7 14295 52 Hospital Hospital NNP cord-005453-4057qib7 14295 53 Egypt Egypt NNP cord-005453-4057qib7 14295 54 ( ( -LRB- cord-005453-4057qib7 14295 55 CCHE CCHE NNP cord-005453-4057qib7 14295 56 ) ) -RRB- cord-005453-4057qib7 14296 1 57357 57357 CD cord-005453-4057qib7 14297 1 from from IN cord-005453-4057qib7 14297 2 November November NNP cord-005453-4057qib7 14297 3 2010 2010 CD cord-005453-4057qib7 14297 4 to to IN cord-005453-4057qib7 14297 5 July July NNP cord-005453-4057qib7 14297 6 2017 2017 CD cord-005453-4057qib7 14297 7 , , , cord-005453-4057qib7 14297 8 the the DT cord-005453-4057qib7 14297 9 treatment treatment NN cord-005453-4057qib7 14297 10 protocol protocol NN cord-005453-4057qib7 14297 11 was be VBD cord-005453-4057qib7 14297 12 adopted adopt VBN cord-005453-4057qib7 14297 13 from from IN cord-005453-4057qib7 14297 14 COG cog NN cord-005453-4057qib7 14297 15 protocol protocol NN cord-005453-4057qib7 14297 16 ( ( -LRB- cord-005453-4057qib7 14297 17 ARET0321 aret0321 NN cord-005453-4057qib7 14297 18 ) ) -RRB- cord-005453-4057qib7 14297 19 as as IN cord-005453-4057qib7 14297 20 all all DT cord-005453-4057qib7 14297 21 patients patient NNS cord-005453-4057qib7 14297 22 received receive VBD cord-005453-4057qib7 14297 23 4 4 CD cord-005453-4057qib7 14297 24 cycles cycle NNS cord-005453-4057qib7 14297 25 induction induction NN cord-005453-4057qib7 14297 26 chemotherapy chemotherapy NN cord-005453-4057qib7 14297 27 followed follow VBN cord-005453-4057qib7 14297 28 by by IN cord-005453-4057qib7 14297 29 consolidation consolidation NN cord-005453-4057qib7 14297 30 myloablative myloablative NNP cord-005453-4057qib7 14297 31 conditioning conditioning NN cord-005453-4057qib7 14297 32 , , , cord-005453-4057qib7 14297 33 CEM CEM NNP cord-005453-4057qib7 14297 34 ( ( -LRB- cord-005453-4057qib7 14297 35 VP16 VP16 NNP cord-005453-4057qib7 14297 36 416.6 416.6 CD cord-005453-4057qib7 14297 37 mg mg NNP cord-005453-4057qib7 14297 38 / / SYM cord-005453-4057qib7 14297 39 m2 m2 NNP cord-005453-4057qib7 14297 40 x3 x3 NNP cord-005453-4057qib7 14297 41 , , , cord-005453-4057qib7 14297 42 Melphalan Melphalan NNP cord-005453-4057qib7 14297 43 : : : cord-005453-4057qib7 14297 44 40 40 CD cord-005453-4057qib7 14297 45 mg mg NNP cord-005453-4057qib7 14297 46 / / SYM cord-005453-4057qib7 14297 47 m2 m2 NNP cord-005453-4057qib7 14297 48 x4 x4 NNP cord-005453-4057qib7 14297 49 , , , cord-005453-4057qib7 14297 50 Carboplatin Carboplatin NNP cord-005453-4057qib7 14297 51 : : : cord-005453-4057qib7 14297 52 500 500 CD cord-005453-4057qib7 14297 53 mg mg NNP cord-005453-4057qib7 14297 54 / / SYM cord-005453-4057qib7 14297 55 m2 m2 NNP cord-005453-4057qib7 14297 56 x3 x3 NNP cord-005453-4057qib7 14297 57 ) ) -RRB- cord-005453-4057qib7 14297 58 and and CC cord-005453-4057qib7 14297 59 stem stem VB cord-005453-4057qib7 14297 60 cell cell NN cord-005453-4057qib7 14297 61 rescue rescue NN cord-005453-4057qib7 14297 62 . . . cord-005453-4057qib7 14298 1 Patients patient NNS cord-005453-4057qib7 14298 2 data datum NNS cord-005453-4057qib7 14298 3 including include VBG cord-005453-4057qib7 14298 4 initial initial JJ cord-005453-4057qib7 14298 5 disease disease NN cord-005453-4057qib7 14298 6 characteristics characteristic NNS cord-005453-4057qib7 14298 7 , , , cord-005453-4057qib7 14298 8 transplant transplant NN cord-005453-4057qib7 14298 9 data datum NNS cord-005453-4057qib7 14298 10 , , , cord-005453-4057qib7 14298 11 and and CC cord-005453-4057qib7 14298 12 survival survival NN cord-005453-4057qib7 14298 13 outcomes outcome NNS cord-005453-4057qib7 14298 14 were be VBD cord-005453-4057qib7 14298 15 collected collect VBN cord-005453-4057qib7 14298 16 and and CC cord-005453-4057qib7 14298 17 analyzed analyze VBN cord-005453-4057qib7 14298 18 Results result NNS cord-005453-4057qib7 14298 19 : : : cord-005453-4057qib7 14298 20 A a DT cord-005453-4057qib7 14298 21 total total NN cord-005453-4057qib7 14298 22 of of IN cord-005453-4057qib7 14298 23 11 11 CD cord-005453-4057qib7 14298 24 cases case NNS cord-005453-4057qib7 14298 25 were be VBD cord-005453-4057qib7 14298 26 included include VBN cord-005453-4057qib7 14298 27 with with IN cord-005453-4057qib7 14298 28 median median JJ cord-005453-4057qib7 14298 29 age age NN cord-005453-4057qib7 14298 30 of of IN cord-005453-4057qib7 14298 31 1.7 1.7 CD cord-005453-4057qib7 14298 32 years year NNS cord-005453-4057qib7 14298 33 , , , cord-005453-4057qib7 14298 34 and and CC cord-005453-4057qib7 14298 35 male male JJ cord-005453-4057qib7 14298 36 to to IN cord-005453-4057qib7 14298 37 female female JJ cord-005453-4057qib7 14298 38 ratio ratio NN cord-005453-4057qib7 14298 39 2.66 2.66 CD cord-005453-4057qib7 14298 40 . . . cord-005453-4057qib7 14299 1 Nine nine CD cord-005453-4057qib7 14299 2 patients patient NNS cord-005453-4057qib7 14299 3 ( ( -LRB- cord-005453-4057qib7 14299 4 81 81 CD cord-005453-4057qib7 14299 5 % % NN cord-005453-4057qib7 14299 6 ) ) -RRB- cord-005453-4057qib7 14299 7 were be VBD cord-005453-4057qib7 14299 8 initially initially RB cord-005453-4057qib7 14299 9 presented present VBN cord-005453-4057qib7 14299 10 by by IN cord-005453-4057qib7 14299 11 extra extra JJ cord-005453-4057qib7 14299 12 ocular ocular JJ cord-005453-4057qib7 14299 13 disease disease NN cord-005453-4057qib7 14299 14 , , , cord-005453-4057qib7 14299 15 while while IN cord-005453-4057qib7 14299 16 2 2 CD cord-005453-4057qib7 14299 17 patients patient NNS cord-005453-4057qib7 14299 18 were be VBD cord-005453-4057qib7 14299 19 presented present VBN cord-005453-4057qib7 14299 20 by by IN cord-005453-4057qib7 14299 21 intra intra JJ cord-005453-4057qib7 14299 22 ocular ocular JJ cord-005453-4057qib7 14299 23 disease disease NN cord-005453-4057qib7 14299 24 and and CC cord-005453-4057qib7 14299 25 progressed progress VBD cord-005453-4057qib7 14299 26 to to IN cord-005453-4057qib7 14299 27 metastatic metastatic JJ cord-005453-4057qib7 14299 28 disease disease NN cord-005453-4057qib7 14299 29 . . . cord-005453-4057qib7 14300 1 According accord VBG cord-005453-4057qib7 14300 2 to to IN cord-005453-4057qib7 14300 3 COG cog NN cord-005453-4057qib7 14300 4 staging staging NN cord-005453-4057qib7 14300 5 of of IN cord-005453-4057qib7 14300 6 extra extra JJ cord-005453-4057qib7 14300 7 ocular ocular JJ cord-005453-4057qib7 14300 8 disease disease NN cord-005453-4057qib7 14300 9 , , , cord-005453-4057qib7 14300 10 4 4 CD cord-005453-4057qib7 14300 11 patients patient NNS cord-005453-4057qib7 14300 12 had have VBD cord-005453-4057qib7 14300 13 stage stage NN cord-005453-4057qib7 14300 14 4a 4a CD cord-005453-4057qib7 14300 15 , , , cord-005453-4057qib7 14300 16 and and CC cord-005453-4057qib7 14300 17 7 7 CD cord-005453-4057qib7 14300 18 were be VBD cord-005453-4057qib7 14300 19 stage stage NN cord-005453-4057qib7 14300 20 4b 4b CD cord-005453-4057qib7 14300 21 ( ( -LRB- cord-005453-4057qib7 14300 22 5 5 CD cord-005453-4057qib7 14300 23 of of IN cord-005453-4057qib7 14300 24 them -PRON- PRP cord-005453-4057qib7 14300 25 had have VBD cord-005453-4057qib7 14300 26 trilateral trilateral JJ cord-005453-4057qib7 14300 27 disease disease NN cord-005453-4057qib7 14300 28 ) ) -RRB- cord-005453-4057qib7 14300 29 . . . cord-005453-4057qib7 14301 1 After after IN cord-005453-4057qib7 14301 2 induction induction NN cord-005453-4057qib7 14301 3 therapy therapy NN cord-005453-4057qib7 14301 4 , , , cord-005453-4057qib7 14301 5 7(63 7(63 CD cord-005453-4057qib7 14301 6 % % NN cord-005453-4057qib7 14301 7 ) ) -RRB- cord-005453-4057qib7 14301 8 showed show VBD cord-005453-4057qib7 14301 9 complete complete JJ cord-005453-4057qib7 14301 10 response response NN cord-005453-4057qib7 14301 11 and and CC cord-005453-4057qib7 14301 12 4 4 CD cord-005453-4057qib7 14301 13 ( ( -LRB- cord-005453-4057qib7 14301 14 36 36 CD cord-005453-4057qib7 14301 15 % % NN cord-005453-4057qib7 14301 16 ) ) -RRB- cord-005453-4057qib7 14301 17 had have VBD cord-005453-4057qib7 14301 18 ≥ ≥ CD cord-005453-4057qib7 14301 19 partial partial JJ cord-005453-4057qib7 14301 20 response response NN cord-005453-4057qib7 14301 21 . . . cord-005453-4057qib7 14302 1 With with IN cord-005453-4057qib7 14302 2 average average JJ cord-005453-4057qib7 14302 3 CD34 CD34 NNP cord-005453-4057qib7 14302 4 count count NN cord-005453-4057qib7 14302 5 of of IN cord-005453-4057qib7 14302 6 4x10 4x10 CD cord-005453-4057qib7 14302 7 6 6 CD cord-005453-4057qib7 14302 8 / / SYM cord-005453-4057qib7 14302 9 kg kg NNS cord-005453-4057qib7 14302 10 , , , cord-005453-4057qib7 14302 11 the the DT cord-005453-4057qib7 14302 12 median median JJ cord-005453-4057qib7 14302 13 time time NN cord-005453-4057qib7 14302 14 to to IN cord-005453-4057qib7 14302 15 ANC ANC NNP cord-005453-4057qib7 14302 16 and and CC cord-005453-4057qib7 14302 17 platelet platelet NN cord-005453-4057qib7 14302 18 engraftment engraftment NN cord-005453-4057qib7 14302 19 were be VBD cord-005453-4057qib7 14302 20 10 10 CD cord-005453-4057qib7 14302 21 days day NNS cord-005453-4057qib7 14302 22 and and CC cord-005453-4057qib7 14302 23 19 19 CD cord-005453-4057qib7 14302 24 days day NNS cord-005453-4057qib7 14302 25 respectively respectively RB cord-005453-4057qib7 14302 26 , , , cord-005453-4057qib7 14302 27 and and CC cord-005453-4057qib7 14302 28 there there EX cord-005453-4057qib7 14302 29 was be VBD cord-005453-4057qib7 14302 30 no no DT cord-005453-4057qib7 14302 31 transplant transplant NN cord-005453-4057qib7 14302 32 related relate VBN cord-005453-4057qib7 14302 33 mortality mortality NN cord-005453-4057qib7 14302 34 . . . cord-005453-4057qib7 14303 1 Post post JJ cord-005453-4057qib7 14303 2 - - JJ cord-005453-4057qib7 14303 3 transplant transplant NN cord-005453-4057qib7 14303 4 radiotherapy radiotherapy NN cord-005453-4057qib7 14303 5 was be VBD cord-005453-4057qib7 14303 6 given give VBN cord-005453-4057qib7 14303 7 only only RB cord-005453-4057qib7 14303 8 to to IN cord-005453-4057qib7 14303 9 2 2 CD cord-005453-4057qib7 14303 10 patients patient NNS cord-005453-4057qib7 14303 11 . . . cord-005453-4057qib7 14304 1 With with IN cord-005453-4057qib7 14304 2 median median JJ cord-005453-4057qib7 14304 3 duration duration NN cord-005453-4057qib7 14304 4 of of IN cord-005453-4057qib7 14304 5 follow follow NN cord-005453-4057qib7 14304 6 up up IN cord-005453-4057qib7 14304 7 of of IN cord-005453-4057qib7 14304 8 32 32 CD cord-005453-4057qib7 14304 9 months month NNS cord-005453-4057qib7 14304 10 , , , cord-005453-4057qib7 14304 11 the the DT cord-005453-4057qib7 14304 12 overall overall JJ cord-005453-4057qib7 14304 13 and and CC cord-005453-4057qib7 14304 14 event event NN cord-005453-4057qib7 14304 15 free free JJ cord-005453-4057qib7 14304 16 survival survival NN cord-005453-4057qib7 14304 17 rates rate NNS cord-005453-4057qib7 14304 18 of of IN cord-005453-4057qib7 14304 19 whole whole JJ cord-005453-4057qib7 14304 20 patients patient NNS cord-005453-4057qib7 14304 21 were be VBD cord-005453-4057qib7 14304 22 88.9 88.9 CD cord-005453-4057qib7 14304 23 % % NN cord-005453-4057qib7 14304 24 and and CC cord-005453-4057qib7 14304 25 87.5 87.5 CD cord-005453-4057qib7 14304 26 % % NN cord-005453-4057qib7 14304 27 respectively respectively RB cord-005453-4057qib7 14304 28 Conclusions conclusion NNS cord-005453-4057qib7 14304 29 : : : cord-005453-4057qib7 14304 30 High high JJ cord-005453-4057qib7 14304 31 dose dose NN cord-005453-4057qib7 14304 32 chemotherapy chemotherapy NN cord-005453-4057qib7 14304 33 and and CC cord-005453-4057qib7 14304 34 stem stem NN cord-005453-4057qib7 14304 35 cell cell NN cord-005453-4057qib7 14304 36 transplantation transplantation NN cord-005453-4057qib7 14304 37 is be VBZ cord-005453-4057qib7 14304 38 a a DT cord-005453-4057qib7 14304 39 promising promising JJ cord-005453-4057qib7 14304 40 potential potential JJ cord-005453-4057qib7 14304 41 curative curative JJ cord-005453-4057qib7 14304 42 option option NN cord-005453-4057qib7 14304 43 for for IN cord-005453-4057qib7 14304 44 patients patient NNS cord-005453-4057qib7 14304 45 with with IN cord-005453-4057qib7 14304 46 metastatic metastatic JJ cord-005453-4057qib7 14304 47 extra extra JJ cord-005453-4057qib7 14304 48 ocular ocular JJ cord-005453-4057qib7 14304 49 Only only RB cord-005453-4057qib7 14304 50 two two CD cord-005453-4057qib7 14304 51 primary primary JJ cord-005453-4057qib7 14304 52 GF gf NN cord-005453-4057qib7 14304 53 ( ( -LRB- cord-005453-4057qib7 14304 54 1.4 1.4 CD cord-005453-4057qib7 14304 55 % % NN cord-005453-4057qib7 14304 56 ) ) -RRB- cord-005453-4057qib7 14304 57 occurred occur VBD cord-005453-4057qib7 14304 58 , , , cord-005453-4057qib7 14304 59 both both CC cord-005453-4057qib7 14304 60 without without IN cord-005453-4057qib7 14304 61 DSA DSA NNP cord-005453-4057qib7 14304 62 . . . cord-005453-4057qib7 14305 1 20 20 CD cord-005453-4057qib7 14305 2 patients patient NNS cord-005453-4057qib7 14305 3 developed develop VBD cord-005453-4057qib7 14305 4 a a DT cord-005453-4057qib7 14305 5 primary primary JJ cord-005453-4057qib7 14305 6 PGF PGF NNP cord-005453-4057qib7 14305 7 ( ( -LRB- cord-005453-4057qib7 14305 8 15 15 CD cord-005453-4057qib7 14305 9 % % NN cord-005453-4057qib7 14305 10 ) ) -RRB- cord-005453-4057qib7 14305 11 . . . cord-005453-4057qib7 14306 1 3-years 3-years JJ cord-005453-4057qib7 14306 2 OS OS NNP cord-005453-4057qib7 14306 3 , , , cord-005453-4057qib7 14306 4 3years 3years JJ cord-005453-4057qib7 14306 5 PFS PFS NNP cord-005453-4057qib7 14306 6 and and CC cord-005453-4057qib7 14306 7 1-year 1-year CD cord-005453-4057qib7 14306 8 NRM NRM NNP cord-005453-4057qib7 14306 9 were be VBD cord-005453-4057qib7 14306 10 analyzed analyze VBN cord-005453-4057qib7 14306 11 according accord VBG cord-005453-4057qib7 14306 12 to to IN cord-005453-4057qib7 14306 13 the the DT cord-005453-4057qib7 14306 14 presence presence NN cord-005453-4057qib7 14306 15 of of IN cord-005453-4057qib7 14306 16 DSA DSA NNP cord-005453-4057qib7 14306 17 in in IN cord-005453-4057qib7 14306 18 comparison comparison NN cord-005453-4057qib7 14306 19 with with IN cord-005453-4057qib7 14306 20 negative negative JJ cord-005453-4057qib7 14306 21 population population NN cord-005453-4057qib7 14306 22 . . . cord-005453-4057qib7 14307 1 No no DT cord-005453-4057qib7 14307 2 statistically statistically RB cord-005453-4057qib7 14307 3 difference difference NN cord-005453-4057qib7 14307 4 was be VBD cord-005453-4057qib7 14307 5 found find VBN cord-005453-4057qib7 14307 6 . . . cord-005453-4057qib7 14308 1 No no DT cord-005453-4057qib7 14308 2 impact impact NN cord-005453-4057qib7 14308 3 of of IN cord-005453-4057qib7 14308 4 the the DT cord-005453-4057qib7 14308 5 presence presence NN cord-005453-4057qib7 14308 6 of of IN cord-005453-4057qib7 14308 7 DSA DSA NNP cord-005453-4057qib7 14308 8 on on IN cord-005453-4057qib7 14308 9 the the DT cord-005453-4057qib7 14308 10 risk risk NN cord-005453-4057qib7 14308 11 of of IN cord-005453-4057qib7 14308 12 developing develop VBG cord-005453-4057qib7 14308 13 GF GF NNP cord-005453-4057qib7 14308 14 and and CC cord-005453-4057qib7 14308 15 PGF PGF NNP cord-005453-4057qib7 14308 16 was be VBD cord-005453-4057qib7 14308 17 revealed reveal VBN cord-005453-4057qib7 14308 18 . . . cord-005453-4057qib7 14309 1 Major major JJ cord-005453-4057qib7 14309 2 outcomes outcome NNS cord-005453-4057qib7 14309 3 of of IN cord-005453-4057qib7 14309 4 transplant transplant NN cord-005453-4057qib7 14309 5 was be VBD cord-005453-4057qib7 14309 6 analyzed analyze VBN cord-005453-4057qib7 14309 7 separately separately RB cord-005453-4057qib7 14309 8 in in IN cord-005453-4057qib7 14309 9 patients patient NNS cord-005453-4057qib7 14309 10 with with IN cord-005453-4057qib7 14309 11 PGF PGF NNP cord-005453-4057qib7 14309 12 and and CC cord-005453-4057qib7 14309 13 good good JJ cord-005453-4057qib7 14309 14 graft graft NN cord-005453-4057qib7 14309 15 function function NN cord-005453-4057qib7 14309 16 ( ( -LRB- cord-005453-4057qib7 14309 17 GGF GGF NNP cord-005453-4057qib7 14309 18 ) ) -RRB- cord-005453-4057qib7 14309 19 . . . cord-005453-4057qib7 14310 1 3-years 3-years JJ cord-005453-4057qib7 14310 2 OS OS NNP cord-005453-4057qib7 14310 3 , , , cord-005453-4057qib7 14310 4 3-years 3-years CD cord-005453-4057qib7 14310 5 PFS PFS NNP cord-005453-4057qib7 14310 6 and and CC cord-005453-4057qib7 14310 7 1year 1year CD cord-005453-4057qib7 14310 8 - - HYPH cord-005453-4057qib7 14310 9 NRM NRM NNP cord-005453-4057qib7 14310 10 in in IN cord-005453-4057qib7 14310 11 GGF GGF NNP cord-005453-4057qib7 14310 12 and and CC cord-005453-4057qib7 14310 13 primary primary JJ cord-005453-4057qib7 14310 14 PGF PGF NNP cord-005453-4057qib7 14310 15 populations population NNS cord-005453-4057qib7 14310 16 were be VBD cord-005453-4057qib7 14310 17 62 62 CD cord-005453-4057qib7 14310 18 % % NN cord-005453-4057qib7 14310 19 vs vs IN cord-005453-4057qib7 14310 20 20 20 CD cord-005453-4057qib7 14310 21 % % NN cord-005453-4057qib7 14310 22 ( ( -LRB- cord-005453-4057qib7 14310 23 p p NN cord-005453-4057qib7 14310 24 < < XX cord-005453-4057qib7 14310 25 0.0001 0.0001 CD cord-005453-4057qib7 14310 26 ) ) -RRB- cord-005453-4057qib7 14310 27 ; ; : cord-005453-4057qib7 14310 28 53 53 CD cord-005453-4057qib7 14310 29 % % NN cord-005453-4057qib7 14310 30 vs vs IN cord-005453-4057qib7 14310 31 20 20 CD cord-005453-4057qib7 14310 32 % % NN cord-005453-4057qib7 14310 33 ( ( -LRB- cord-005453-4057qib7 14310 34 p p NN cord-005453-4057qib7 14310 35 < < XX cord-005453-4057qib7 14310 36 0.001 0.001 CD cord-005453-4057qib7 14310 37 ) ) -RRB- cord-005453-4057qib7 14310 38 , , , cord-005453-4057qib7 14310 39 12 12 CD cord-005453-4057qib7 14310 40 % % NN cord-005453-4057qib7 14310 41 vs vs IN cord-005453-4057qib7 14310 42 40 40 CD cord-005453-4057qib7 14310 43 % % NN cord-005453-4057qib7 14310 44 ( ( -LRB- cord-005453-4057qib7 14310 45 p=0.009 p=0.009 NN cord-005453-4057qib7 14310 46 ) ) -RRB- cord-005453-4057qib7 14310 47 , , , cord-005453-4057qib7 14310 48 respectively respectively RB cord-005453-4057qib7 14310 49 . . . cord-005453-4057qib7 14311 1 Conclusions conclusion NNS cord-005453-4057qib7 14311 2 : : : cord-005453-4057qib7 14312 1 The the DT cord-005453-4057qib7 14312 2 presence presence NN cord-005453-4057qib7 14312 3 of of IN cord-005453-4057qib7 14312 4 low low JJ cord-005453-4057qib7 14312 5 level level NN cord-005453-4057qib7 14312 6 of of IN cord-005453-4057qib7 14312 7 DSA DSA NNP cord-005453-4057qib7 14312 8 in in IN cord-005453-4057qib7 14312 9 the the DT cord-005453-4057qib7 14312 10 absence absence NN cord-005453-4057qib7 14312 11 of of IN cord-005453-4057qib7 14312 12 desensitization desensitization NN cord-005453-4057qib7 14312 13 does do VBZ cord-005453-4057qib7 14312 14 n't not RB cord-005453-4057qib7 14312 15 correlate correlate VB cord-005453-4057qib7 14312 16 with with IN cord-005453-4057qib7 14312 17 the the DT cord-005453-4057qib7 14312 18 risk risk NN cord-005453-4057qib7 14312 19 of of IN cord-005453-4057qib7 14312 20 developing develop VBG cord-005453-4057qib7 14312 21 GF GF NNP cord-005453-4057qib7 14312 22 and and CC cord-005453-4057qib7 14312 23 PGF PGF NNP cord-005453-4057qib7 14312 24 . . . cord-005453-4057qib7 14313 1 Patients patient NNS cord-005453-4057qib7 14313 2 who who WP cord-005453-4057qib7 14313 3 experienced experience VBD cord-005453-4057qib7 14313 4 a a DT cord-005453-4057qib7 14313 5 PGF PGF NNP cord-005453-4057qib7 14313 6 had have VBD cord-005453-4057qib7 14313 7 worse bad JJR cord-005453-4057qib7 14313 8 outcomes outcome NNS cord-005453-4057qib7 14313 9 in in IN cord-005453-4057qib7 14313 10 comparison comparison NN cord-005453-4057qib7 14313 11 with with IN cord-005453-4057qib7 14313 12 patients patient NNS cord-005453-4057qib7 14313 13 with with IN cord-005453-4057qib7 14313 14 GGF GGF NNP cord-005453-4057qib7 14313 15 . . . cord-005453-4057qib7 14314 1 Disclosure disclosure NN cord-005453-4057qib7 14314 2 : : : cord-005453-4057qib7 14314 3 Nothing nothing NN cord-005453-4057qib7 14314 4 to to TO cord-005453-4057qib7 14314 5 declare declare VB cord-005453-4057qib7 14314 6 . . . cord-005453-4057qib7 14315 1 The the DT cord-005453-4057qib7 14315 2 impact impact NN cord-005453-4057qib7 14315 3 of of IN cord-005453-4057qib7 14315 4 HLA HLA NNP cord-005453-4057qib7 14315 5 - - HYPH cord-005453-4057qib7 14315 6 DPB1 DPB1 NNP cord-005453-4057qib7 14315 7 mismatch mismatch NN cord-005453-4057qib7 14315 8 in in IN cord-005453-4057qib7 14316 1 T t NN cord-005453-4057qib7 14316 2 - - HYPH cord-005453-4057qib7 14316 3 cell cell NN cord-005453-4057qib7 14316 4 replete replete JJ cord-005453-4057qib7 14316 5 unrelated unrelated JJ cord-005453-4057qib7 14316 6 donor donor NN cord-005453-4057qib7 14316 7 allogeneic allogeneic NN cord-005453-4057qib7 14316 8 stem stem NN cord-005453-4057qib7 14316 9 cell cell NN cord-005453-4057qib7 14316 10 transplantation transplantation NN cord-005453-4057qib7 14316 11 Background background NN cord-005453-4057qib7 14316 12 : : : cord-005453-4057qib7 14317 1 High high JJ cord-005453-4057qib7 14317 2 resolution resolution NN cord-005453-4057qib7 14317 3 matching matching NN cord-005453-4057qib7 14317 4 of of IN cord-005453-4057qib7 14317 5 donor donor NN cord-005453-4057qib7 14317 6 - - HYPH cord-005453-4057qib7 14317 7 recipient recipient NN cord-005453-4057qib7 14317 8 HLA HLA NNP cord-005453-4057qib7 14317 9 improves improve VBZ cord-005453-4057qib7 14317 10 outcome outcome NN cord-005453-4057qib7 14317 11 in in IN cord-005453-4057qib7 14317 12 allogeneic allogeneic NN cord-005453-4057qib7 14317 13 stem stem NN cord-005453-4057qib7 14317 14 cell cell NN cord-005453-4057qib7 14317 15 transplants transplant NNS cord-005453-4057qib7 14317 16 . . . cord-005453-4057qib7 14318 1 Matching match VBG cord-005453-4057qib7 14318 2 for for IN cord-005453-4057qib7 14318 3 HLA HLA NNP cord-005453-4057qib7 14318 4 - - HYPH cord-005453-4057qib7 14318 5 A A NNP cord-005453-4057qib7 14318 6 , , , cord-005453-4057qib7 14318 7 -B -b ADD cord-005453-4057qib7 14318 8 , , , cord-005453-4057qib7 14318 9 -C -C NNS cord-005453-4057qib7 14318 10 , , , cord-005453-4057qib7 14318 11 -DRB1 -DRB1 NNP cord-005453-4057qib7 14319 1 and and CC cord-005453-4057qib7 14319 2 -DQ -dq NN cord-005453-4057qib7 14319 3 is be VBZ cord-005453-4057qib7 14319 4 mandatory mandatory JJ cord-005453-4057qib7 14319 5 in in IN cord-005453-4057qib7 14319 6 our -PRON- PRP$ cord-005453-4057qib7 14319 7 transplant transplant NN cord-005453-4057qib7 14319 8 centre centre NN cord-005453-4057qib7 14319 9 , , , cord-005453-4057qib7 14319 10 to to TO cord-005453-4057qib7 14319 11 identify identify VB cord-005453-4057qib7 14319 12 10/10 10/10 CD cord-005453-4057qib7 14319 13 or or CC cord-005453-4057qib7 14319 14 9/10 9/10 CD cord-005453-4057qib7 14319 15 matched match VBN cord-005453-4057qib7 14319 16 unrelated unrelated JJ cord-005453-4057qib7 14319 17 donors donor NNS cord-005453-4057qib7 14319 18 . . . cord-005453-4057qib7 14320 1 High high JJ cord-005453-4057qib7 14320 2 resolution resolution NN cord-005453-4057qib7 14320 3 matching matching NN cord-005453-4057qib7 14320 4 for for IN cord-005453-4057qib7 14320 5 DPB1 DPB1 NNP cord-005453-4057qib7 14320 6 has have VBZ cord-005453-4057qib7 14320 7 been be VBN cord-005453-4057qib7 14320 8 added add VBN cord-005453-4057qib7 14320 9 over over IN cord-005453-4057qib7 14320 10 the the DT cord-005453-4057qib7 14320 11 last last JJ cord-005453-4057qib7 14320 12 10 10 CD cord-005453-4057qib7 14320 13 - - SYM cord-005453-4057qib7 14320 14 15 15 CD cord-005453-4057qib7 14320 15 years year NNS cord-005453-4057qib7 14320 16 . . . cord-005453-4057qib7 14321 1 However however RB cord-005453-4057qib7 14321 2 , , , cord-005453-4057qib7 14321 3 the the DT cord-005453-4057qib7 14321 4 role role NN cord-005453-4057qib7 14321 5 of of IN cord-005453-4057qib7 14321 6 DPB1 dpb1 JJ cord-005453-4057qib7 14321 7 matching matching NN cord-005453-4057qib7 14321 8 is be VBZ cord-005453-4057qib7 14321 9 not not RB cord-005453-4057qib7 14321 10 yet yet RB cord-005453-4057qib7 14321 11 clearly clearly RB cord-005453-4057qib7 14321 12 defined define VBN cord-005453-4057qib7 14321 13 . . . cord-005453-4057qib7 14322 1 Methods method NNS cord-005453-4057qib7 14322 2 : : : cord-005453-4057qib7 14322 3 In in IN cord-005453-4057qib7 14322 4 this this DT cord-005453-4057qib7 14322 5 study study NN cord-005453-4057qib7 14322 6 , , , cord-005453-4057qib7 14322 7 we -PRON- PRP cord-005453-4057qib7 14322 8 retrospectively retrospectively RB cord-005453-4057qib7 14322 9 analyzed analyze VBD cord-005453-4057qib7 14322 10 the the DT cord-005453-4057qib7 14322 11 impact impact NN cord-005453-4057qib7 14322 12 of of IN cord-005453-4057qib7 14322 13 HLA HLA NNP cord-005453-4057qib7 14322 14 - - HYPH cord-005453-4057qib7 14322 15 DPB1 DPB1 NNP cord-005453-4057qib7 14322 16 matching matching NN cord-005453-4057qib7 14322 17 on on IN cord-005453-4057qib7 14322 18 the the DT cord-005453-4057qib7 14322 19 outcome outcome NN cord-005453-4057qib7 14322 20 of of IN cord-005453-4057qib7 14322 21 T t NN cord-005453-4057qib7 14322 22 - - HYPH cord-005453-4057qib7 14322 23 cell cell NN cord-005453-4057qib7 14322 24 replete replete NN cord-005453-4057qib7 14322 25 allogeneic allogeneic NN cord-005453-4057qib7 14322 26 hematopoietic hematopoietic JJ cord-005453-4057qib7 14322 27 stem stem NN cord-005453-4057qib7 14322 28 cell cell NN cord-005453-4057qib7 14322 29 transplants transplant NNS cord-005453-4057qib7 14322 30 with with IN cord-005453-4057qib7 14322 31 CyA cya NN cord-005453-4057qib7 14322 32 / / SYM cord-005453-4057qib7 14322 33 Mtx Mtx NNP cord-005453-4057qib7 14322 34 - - : cord-005453-4057qib7 14322 35 and and CC cord-005453-4057qib7 14322 36 without without IN cord-005453-4057qib7 14322 37 ATG ATG NNP cord-005453-4057qib7 14322 38 as as IN cord-005453-4057qib7 14322 39 GVHD GVHD NNP cord-005453-4057qib7 14322 40 prophylaxis prophylaxis NN cord-005453-4057qib7 14322 41 in in IN cord-005453-4057qib7 14322 42 patients patient NNS cord-005453-4057qib7 14322 43 with with IN cord-005453-4057qib7 14322 44 hematological hematological JJ cord-005453-4057qib7 14322 45 malignancies malignancy NNS cord-005453-4057qib7 14322 46 at at IN cord-005453-4057qib7 14322 47 Oslo Oslo NNP cord-005453-4057qib7 14322 48 University University NNP cord-005453-4057qib7 14322 49 Hospital Hospital NNP cord-005453-4057qib7 14322 50 between between IN cord-005453-4057qib7 14322 51 2005 2005 CD cord-005453-4057qib7 14322 52 and and CC cord-005453-4057qib7 14322 53 2017 2017 CD cord-005453-4057qib7 14322 54 . . . cord-005453-4057qib7 14323 1 301 301 CD cord-005453-4057qib7 14323 2 patients patient NNS cord-005453-4057qib7 14323 3 with with IN cord-005453-4057qib7 14323 4 an an DT cord-005453-4057qib7 14323 5 unrelated unrelated JJ cord-005453-4057qib7 14323 6 donor donor NN cord-005453-4057qib7 14323 7 fully fully RB cord-005453-4057qib7 14323 8 matched match VBN cord-005453-4057qib7 14323 9 ( ( -LRB- cord-005453-4057qib7 14323 10 10/10 10/10 CD cord-005453-4057qib7 14323 11 ) ) -RRB- cord-005453-4057qib7 14323 12 at at IN cord-005453-4057qib7 14323 13 HLA HLA NNP cord-005453-4057qib7 14323 14 - - HYPH cord-005453-4057qib7 14323 15 A A NNP cord-005453-4057qib7 14323 16 , , , cord-005453-4057qib7 14323 17 -B -b ADD cord-005453-4057qib7 14323 18 , , , cord-005453-4057qib7 14323 19 -C -C NNS cord-005453-4057qib7 14323 20 , , , cord-005453-4057qib7 14323 21 -DRB1 -drb1 NN cord-005453-4057qib7 14323 22 and and CC cord-005453-4057qib7 14323 23 -DQB1 -dqb1 NN cord-005453-4057qib7 14323 24 loci locus NNS cord-005453-4057qib7 14323 25 were be VBD cord-005453-4057qib7 14323 26 included include VBN cord-005453-4057qib7 14323 27 . . . cord-005453-4057qib7 14324 1 Further further RB cord-005453-4057qib7 14324 2 , , , cord-005453-4057qib7 14324 3 87 87 CD cord-005453-4057qib7 14324 4 patientrecipient patientrecipient NN cord-005453-4057qib7 14324 5 pairs pair NNS cord-005453-4057qib7 14324 6 were be VBD cord-005453-4057qib7 14324 7 also also RB cord-005453-4057qib7 14324 8 fully fully RB cord-005453-4057qib7 14324 9 matched match VBN cord-005453-4057qib7 14324 10 on on IN cord-005453-4057qib7 14324 11 DPB1 DPB1 NNP cord-005453-4057qib7 14324 12 ( ( -LRB- cord-005453-4057qib7 14324 13 12/12 12/12 CD cord-005453-4057qib7 14324 14 ) ) -RRB- cord-005453-4057qib7 14324 15 ; ; : cord-005453-4057qib7 14324 16 118 118 CD cord-005453-4057qib7 14324 17 had have VBD cord-005453-4057qib7 14324 18 permissive permissive JJ cord-005453-4057qib7 14324 19 and and CC cord-005453-4057qib7 14324 20 96 96 CD cord-005453-4057qib7 14324 21 had have VBD cord-005453-4057qib7 14324 22 non non JJ cord-005453-4057qib7 14324 23 - - JJ cord-005453-4057qib7 14324 24 permissive permissive JJ cord-005453-4057qib7 14324 25 mimatches mimatche NNS cord-005453-4057qib7 14324 26 of of IN cord-005453-4057qib7 14324 27 one one CD cord-005453-4057qib7 14324 28 or or CC cord-005453-4057qib7 14324 29 two two CD cord-005453-4057qib7 14324 30 DPB1 dpb1 JJ cord-005453-4057qib7 14324 31 alleles allele NNS cord-005453-4057qib7 14324 32 . . . cord-005453-4057qib7 14325 1 The the DT cord-005453-4057qib7 14325 2 Three three CD cord-005453-4057qib7 14325 3 Groups Groups NNPS cord-005453-4057qib7 14325 4 were be VBD cord-005453-4057qib7 14325 5 comparable comparable JJ cord-005453-4057qib7 14325 6 with with IN cord-005453-4057qib7 14325 7 respect respect NN cord-005453-4057qib7 14325 8 to to IN cord-005453-4057qib7 14325 9 diagnosis diagnosis NN cord-005453-4057qib7 14325 10 , , , cord-005453-4057qib7 14325 11 gender gender NN cord-005453-4057qib7 14325 12 , , , cord-005453-4057qib7 14325 13 age age NN cord-005453-4057qib7 14325 14 , , , cord-005453-4057qib7 14325 15 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 14325 16 serostatus serostatus NN cord-005453-4057qib7 14325 17 and and CC cord-005453-4057qib7 14325 18 conditioning conditioning NN cord-005453-4057qib7 14325 19 regimen regimen NN cord-005453-4057qib7 14325 20 . . . cord-005453-4057qib7 14326 1 Results result NNS cord-005453-4057qib7 14326 2 : : : cord-005453-4057qib7 14327 1 Cumulative cumulative JJ cord-005453-4057qib7 14327 2 incidence incidence NN cord-005453-4057qib7 14327 3 of of IN cord-005453-4057qib7 14327 4 relapse relapse NN cord-005453-4057qib7 14327 5 at at IN cord-005453-4057qib7 14327 6 5 5 CD cord-005453-4057qib7 14327 7 years year NNS cord-005453-4057qib7 14327 8 were be VBD cord-005453-4057qib7 14327 9 significantly significantly RB cord-005453-4057qib7 14327 10 higher high JJR cord-005453-4057qib7 14327 11 in in IN cord-005453-4057qib7 14327 12 the the DT cord-005453-4057qib7 14327 13 DPB1 DPB1 NNP cord-005453-4057qib7 14327 14 matched match VBN cord-005453-4057qib7 14327 15 pairs pair NNS cord-005453-4057qib7 14327 16 compared compare VBN cord-005453-4057qib7 14327 17 with with IN cord-005453-4057qib7 14327 18 the the DT cord-005453-4057qib7 14327 19 permissive permissive JJ cord-005453-4057qib7 14327 20 and and CC cord-005453-4057qib7 14327 21 non non JJ cord-005453-4057qib7 14327 22 - - JJ cord-005453-4057qib7 14327 23 permissive permissive JJ cord-005453-4057qib7 14327 24 mimatched mimatche VBN cord-005453-4057qib7 14327 25 ones one NNS cord-005453-4057qib7 14327 26 , , , cord-005453-4057qib7 14327 27 at at IN cord-005453-4057qib7 14327 28 40 40 CD cord-005453-4057qib7 14327 29 % % NN cord-005453-4057qib7 14327 30 vs vs IN cord-005453-4057qib7 14327 31 22 22 CD cord-005453-4057qib7 14327 32 % % NN cord-005453-4057qib7 14327 33 and and CC cord-005453-4057qib7 14327 34 13 13 CD cord-005453-4057qib7 14327 35 % % NN cord-005453-4057qib7 14327 36 ( ( -LRB- cord-005453-4057qib7 14327 37 p p NN cord-005453-4057qib7 14327 38 < < XX cord-005453-4057qib7 14327 39 0.001 0.001 CD cord-005453-4057qib7 14327 40 ) ) -RRB- cord-005453-4057qib7 14327 41 respectively respectively RB cord-005453-4057qib7 14327 42 . . . cord-005453-4057qib7 14328 1 Relpase Relpase NNP cord-005453-4057qib7 14328 2 free free JJ cord-005453-4057qib7 14328 3 survival survival NN cord-005453-4057qib7 14328 4 and and CC cord-005453-4057qib7 14328 5 overall overall JJ cord-005453-4057qib7 14328 6 survival survival NN cord-005453-4057qib7 14328 7 were be VBD cord-005453-4057qib7 14328 8 superior superior JJ cord-005453-4057qib7 14328 9 in in IN cord-005453-4057qib7 14328 10 the the DT cord-005453-4057qib7 14328 11 nonpermissive nonpermissive JJ cord-005453-4057qib7 14328 12 and and CC cord-005453-4057qib7 14328 13 permissive permissive JJ cord-005453-4057qib7 14328 14 DBP1 DBP1 NNP cord-005453-4057qib7 14328 15 mismatched mismatched JJ cord-005453-4057qib7 14328 16 groups group NNS cord-005453-4057qib7 14328 17 vs vs IN cord-005453-4057qib7 14328 18 the the DT cord-005453-4057qib7 14328 19 fully fully RB cord-005453-4057qib7 14328 20 matched match VBN cord-005453-4057qib7 14328 21 , , , cord-005453-4057qib7 14328 22 at at IN cord-005453-4057qib7 14328 23 60 60 CD cord-005453-4057qib7 14328 24 % % NN cord-005453-4057qib7 14328 25 and and CC cord-005453-4057qib7 14328 26 49 49 CD cord-005453-4057qib7 14328 27 % % NN cord-005453-4057qib7 14328 28 vs vs IN cord-005453-4057qib7 14328 29 29 29 CD cord-005453-4057qib7 14328 30 % % NN cord-005453-4057qib7 14328 31 ( ( -LRB- cord-005453-4057qib7 14328 32 p=0.01 p=0.01 NNP cord-005453-4057qib7 14328 33 ) ) -RRB- cord-005453-4057qib7 14328 34 and and CC cord-005453-4057qib7 14328 35 59 59 CD cord-005453-4057qib7 14328 36 % % NN cord-005453-4057qib7 14328 37 and and CC cord-005453-4057qib7 14328 38 53 53 CD cord-005453-4057qib7 14328 39 % % NN cord-005453-4057qib7 14328 40 vs vs IN cord-005453-4057qib7 14328 41 40 40 CD cord-005453-4057qib7 14328 42 % % NN cord-005453-4057qib7 14328 43 ( ( -LRB- cord-005453-4057qib7 14328 44 p=0.09 p=0.09 NN cord-005453-4057qib7 14328 45 ) ) -RRB- cord-005453-4057qib7 14328 46 respectively respectively RB cord-005453-4057qib7 14328 47 . . . cord-005453-4057qib7 14329 1 No no DT cord-005453-4057qib7 14329 2 difference difference NN cord-005453-4057qib7 14329 3 in in IN cord-005453-4057qib7 14329 4 frequency frequency NN cord-005453-4057qib7 14329 5 of of IN cord-005453-4057qib7 14329 6 acute acute JJ cord-005453-4057qib7 14329 7 GVHD GVHD NNP cord-005453-4057qib7 14329 8 grade grade NN cord-005453-4057qib7 14329 9 II II NNP cord-005453-4057qib7 14329 10 - - HYPH cord-005453-4057qib7 14329 11 IV IV NNP cord-005453-4057qib7 14329 12 between between IN cord-005453-4057qib7 14329 13 the the DT cord-005453-4057qib7 14329 14 three three CD cord-005453-4057qib7 14329 15 groups group NNS cord-005453-4057qib7 14329 16 were be VBD cord-005453-4057qib7 14329 17 found find VBN cord-005453-4057qib7 14329 18 ; ; : cord-005453-4057qib7 14329 19 DP DP NNP cord-005453-4057qib7 14329 20 match match VBP cord-005453-4057qib7 14329 21 43 43 CD cord-005453-4057qib7 14329 22 % % NN cord-005453-4057qib7 14329 23 , , , cord-005453-4057qib7 14329 24 permissive permissive JJ cord-005453-4057qib7 14329 25 mismatch mismatch NN cord-005453-4057qib7 14329 26 40 40 CD cord-005453-4057qib7 14329 27 % % NN cord-005453-4057qib7 14329 28 and and CC cord-005453-4057qib7 14329 29 non non JJ cord-005453-4057qib7 14329 30 - - JJ cord-005453-4057qib7 14329 31 permissive permissive JJ cord-005453-4057qib7 14329 32 mismatched mismatch VBN cord-005453-4057qib7 14329 33 48 48 CD cord-005453-4057qib7 14329 34 % % NN cord-005453-4057qib7 14330 1 ( ( -LRB- cord-005453-4057qib7 14330 2 p=0.49 p=0.49 NNP cord-005453-4057qib7 14330 3 ) ) -RRB- cord-005453-4057qib7 14330 4 . . . cord-005453-4057qib7 14331 1 Neither neither DT cord-005453-4057qib7 14331 2 was be VBD cord-005453-4057qib7 14331 3 there there EX cord-005453-4057qib7 14331 4 a a DT cord-005453-4057qib7 14331 5 difference difference NN cord-005453-4057qib7 14331 6 seen see VBN cord-005453-4057qib7 14331 7 in in IN cord-005453-4057qib7 14331 8 GVHD GVHD NNP cord-005453-4057qib7 14331 9 grade grade NN cord-005453-4057qib7 14331 10 III III NNP cord-005453-4057qib7 14331 11 - - HYPH cord-005453-4057qib7 14331 12 IV IV NNP cord-005453-4057qib7 14331 13 ; ; : cord-005453-4057qib7 14331 14 12 12 CD cord-005453-4057qib7 14331 15 % % NN cord-005453-4057qib7 14331 16 vs vs IN cord-005453-4057qib7 14331 17 17 17 CD cord-005453-4057qib7 14331 18 % % NN cord-005453-4057qib7 14331 19 vs vs IN cord-005453-4057qib7 14331 20 11 11 CD cord-005453-4057qib7 14331 21 % % NN cord-005453-4057qib7 14331 22 , , , cord-005453-4057qib7 14331 23 respectively respectively RB cord-005453-4057qib7 14331 24 . . . cord-005453-4057qib7 14332 1 Finally finally RB cord-005453-4057qib7 14332 2 , , , cord-005453-4057qib7 14332 3 there there EX cord-005453-4057qib7 14332 4 were be VBD cord-005453-4057qib7 14332 5 similar similar JJ cord-005453-4057qib7 14332 6 outcomes outcome NNS cord-005453-4057qib7 14332 7 between between IN cord-005453-4057qib7 14332 8 the the DT cord-005453-4057qib7 14332 9 three three CD cord-005453-4057qib7 14332 10 groups group NNS cord-005453-4057qib7 14332 11 regarding regard VBG cord-005453-4057qib7 14332 12 chronic chronic JJ cord-005453-4057qib7 14332 13 GVHD GVHD NNP cord-005453-4057qib7 14332 14 and and CC cord-005453-4057qib7 14332 15 TRM TRM NNP cord-005453-4057qib7 14332 16 . . . cord-005453-4057qib7 14333 1 In in IN cord-005453-4057qib7 14333 2 corrected correct VBN cord-005453-4057qib7 14333 3 multivariate multivariate JJ cord-005453-4057qib7 14333 4 analysis analysis NN cord-005453-4057qib7 14333 5 , , , cord-005453-4057qib7 14333 6 only only RB cord-005453-4057qib7 14333 7 DP dp NN cord-005453-4057qib7 14333 8 matching matching NN cord-005453-4057qib7 14333 9 had have VBD cord-005453-4057qib7 14333 10 significant significant JJ cord-005453-4057qib7 14333 11 influence influence NN cord-005453-4057qib7 14333 12 on on IN cord-005453-4057qib7 14333 13 mortality mortality NN cord-005453-4057qib7 14333 14 and and CC cord-005453-4057qib7 14333 15 survival survival NN cord-005453-4057qib7 14333 16 . . . cord-005453-4057qib7 14334 1 Conclusions conclusion NNS cord-005453-4057qib7 14334 2 : : : cord-005453-4057qib7 14335 1 Our -PRON- PRP$ cord-005453-4057qib7 14335 2 results result NNS cord-005453-4057qib7 14335 3 show show VBP cord-005453-4057qib7 14335 4 a a DT cord-005453-4057qib7 14335 5 favorable favorable JJ cord-005453-4057qib7 14335 6 relapse relapse NN cord-005453-4057qib7 14335 7 free free JJ cord-005453-4057qib7 14335 8 and and CC cord-005453-4057qib7 14335 9 overall overall JJ cord-005453-4057qib7 14335 10 survival survival NN cord-005453-4057qib7 14335 11 following follow VBG cord-005453-4057qib7 14335 12 a a DT cord-005453-4057qib7 14335 13 MUD mud NN cord-005453-4057qib7 14335 14 allotransplant allotransplant JJ cord-005453-4057qib7 14335 15 with with IN cord-005453-4057qib7 14335 16 a a DT cord-005453-4057qib7 14335 17 DPB1 dpb1 JJ cord-005453-4057qib7 14335 18 permissive permissive JJ cord-005453-4057qib7 14335 19 or or CC cord-005453-4057qib7 14335 20 non non JJ cord-005453-4057qib7 14335 21 - - JJ cord-005453-4057qib7 14335 22 permissive permissive JJ cord-005453-4057qib7 14335 23 mismatched mismatched JJ cord-005453-4057qib7 14335 24 donor donor NN cord-005453-4057qib7 14335 25 compared compare VBN cord-005453-4057qib7 14335 26 to to IN cord-005453-4057qib7 14335 27 a a DT cord-005453-4057qib7 14335 28 fully fully RB cord-005453-4057qib7 14335 29 DPB1 dpb1 JJ cord-005453-4057qib7 14335 30 matched match VBN cord-005453-4057qib7 14335 31 . . . cord-005453-4057qib7 14336 1 This this DT cord-005453-4057qib7 14336 2 is be VBZ cord-005453-4057qib7 14336 3 likely likely JJ cord-005453-4057qib7 14336 4 due due IN cord-005453-4057qib7 14336 5 to to IN cord-005453-4057qib7 14336 6 an an DT cord-005453-4057qib7 14336 7 increased increase VBN cord-005453-4057qib7 14336 8 GvL gvl NN cord-005453-4057qib7 14336 9 - - HYPH cord-005453-4057qib7 14336 10 effect effect NN cord-005453-4057qib7 14336 11 in in IN cord-005453-4057qib7 14336 12 DPB1 dpb1 JJ cord-005453-4057qib7 14336 13 mismatched mismatched JJ cord-005453-4057qib7 14336 14 groups group NNS cord-005453-4057qib7 14336 15 without without IN cord-005453-4057qib7 14336 16 the the DT cord-005453-4057qib7 14336 17 counterbalance counterbalance NN cord-005453-4057qib7 14336 18 of of IN cord-005453-4057qib7 14336 19 increased increase VBN cord-005453-4057qib7 14336 20 acute acute JJ cord-005453-4057qib7 14336 21 GVHD GVHD NNP cord-005453-4057qib7 14336 22 and and CC cord-005453-4057qib7 14336 23 TRM TRM NNP cord-005453-4057qib7 14336 24 . . . cord-005453-4057qib7 14337 1 Disclosure disclosure NN cord-005453-4057qib7 14337 2 : : : cord-005453-4057qib7 14337 3 Nothing nothing NN cord-005453-4057qib7 14337 4 to to TO cord-005453-4057qib7 14337 5 declare declare VB cord-005453-4057qib7 14337 6 P662 P662 NNS cord-005453-4057qib7 14338 1 A a DT cord-005453-4057qib7 14338 2 haploidentical haploidentical JJ cord-005453-4057qib7 14338 3 may may MD cord-005453-4057qib7 14338 4 be be VB cord-005453-4057qib7 14338 5 a a DT cord-005453-4057qib7 14338 6 better well JJR cord-005453-4057qib7 14338 7 choice choice NN cord-005453-4057qib7 14338 8 than than IN cord-005453-4057qib7 14338 9 a a DT cord-005453-4057qib7 14338 10 female female JJ cord-005453-4057qib7 14338 11 genoidentical genoidentical JJ cord-005453-4057qib7 14338 12 donor donor NN cord-005453-4057qib7 14338 13 to to TO cord-005453-4057qib7 14338 14 transplant transplant VB cord-005453-4057qib7 14338 15 a a DT cord-005453-4057qib7 14338 16 patient patient NN cord-005453-4057qib7 14338 17 with with IN cord-005453-4057qib7 14338 18 high high JJ cord-005453-4057qib7 14338 19 risk risk NN cord-005453-4057qib7 14338 20 acute acute JJ cord-005453-4057qib7 14338 21 myelogenous myelogenous NN cord-005453-4057qib7 14338 22 leukemia leukemia NN cord-005453-4057qib7 14338 23 in in IN cord-005453-4057qib7 14338 24 first first JJ cord-005453-4057qib7 14338 25 remission remission NN cord-005453-4057qib7 14338 26 Norbert Norbert NNP cord-005453-4057qib7 14338 27 Gorin Gorin NNP cord-005453-4057qib7 14338 28 1 1 CD cord-005453-4057qib7 14338 29 , , , cord-005453-4057qib7 14338 30 Myriam Myriam NNP cord-005453-4057qib7 14338 31 Labopin Labopin NNP cord-005453-4057qib7 14338 32 1 1 CD cord-005453-4057qib7 14338 33 , , , cord-005453-4057qib7 14338 34 Didier Didier NNP cord-005453-4057qib7 14338 35 Blaise Blaise NNP cord-005453-4057qib7 14338 36 2 2 CD cord-005453-4057qib7 14338 37 , , , cord-005453-4057qib7 14338 38 Goda Goda NNP cord-005453-4057qib7 14338 39 Choi Choi NNP cord-005453-4057qib7 14338 40 3 3 CD cord-005453-4057qib7 14338 41 , , , cord-005453-4057qib7 14338 42 Gerard Gerard NNP cord-005453-4057qib7 14338 43 Socie Socie NNP cord-005453-4057qib7 14338 44 4 4 CD cord-005453-4057qib7 14338 45 , , , cord-005453-4057qib7 14338 46 Jean Jean NNP cord-005453-4057qib7 14338 47 Henri Henri NNP cord-005453-4057qib7 14338 48 Bourhis Bourhis NNP cord-005453-4057qib7 14338 49 5 5 CD cord-005453-4057qib7 14338 50 , , , cord-005453-4057qib7 14338 51 Fabio Fabio NNP cord-005453-4057qib7 14338 52 Ciceri Ciceri NNP cord-005453-4057qib7 14338 53 6 6 CD cord-005453-4057qib7 14338 54 , , , cord-005453-4057qib7 14338 55 Emmanuelle Emmanuelle NNP cord-005453-4057qib7 14338 56 Polge Polge NNP cord-005453-4057qib7 14338 57 7 7 CD cord-005453-4057qib7 14338 58 , , , cord-005453-4057qib7 14338 59 Arnon Arnon NNP cord-005453-4057qib7 14338 60 Nagler Nagler NNP cord-005453-4057qib7 14338 61 8 8 CD cord-005453-4057qib7 14338 62 , , , cord-005453-4057qib7 14338 63 Mohamad Mohamad NNP cord-005453-4057qib7 14338 64 Mohty Mohty NNP cord-005453-4057qib7 14338 65 1 1 CD cord-005453-4057qib7 14338 66 China China NNP cord-005453-4057qib7 14338 67 , , , cord-005453-4057qib7 14338 68 3 3 CD cord-005453-4057qib7 14338 69 The the DT cord-005453-4057qib7 14338 70 First First NNP cord-005453-4057qib7 14338 71 Affiliated Affiliated NNP cord-005453-4057qib7 14338 72 Hospital Hospital NNP cord-005453-4057qib7 14338 73 of of IN cord-005453-4057qib7 14338 74 Soochow Soochow NNP cord-005453-4057qib7 14338 75 University University NNP cord-005453-4057qib7 14338 76 , , , cord-005453-4057qib7 14338 77 Hematology Hematology NNP cord-005453-4057qib7 14338 78 , , , cord-005453-4057qib7 14338 79 Suzhou Suzhou NNP cord-005453-4057qib7 14338 80 , , , cord-005453-4057qib7 14339 1 China China NNP cord-005453-4057qib7 14339 2 Background Background NNP cord-005453-4057qib7 14339 3 : : : cord-005453-4057qib7 14340 1 Despite despite IN cord-005453-4057qib7 14340 2 the the DT cord-005453-4057qib7 14340 3 incidence incidence NN cord-005453-4057qib7 14340 4 of of IN cord-005453-4057qib7 14340 5 leukemia leukemia NN cord-005453-4057qib7 14340 6 increases increase NNS cord-005453-4057qib7 14340 7 with with IN cord-005453-4057qib7 14340 8 age age NN cord-005453-4057qib7 14340 9 , , , cord-005453-4057qib7 14340 10 currently currently RB cord-005453-4057qib7 14340 11 the the DT cord-005453-4057qib7 14340 12 geriatric geriatric JJ cord-005453-4057qib7 14340 13 population population NN cord-005453-4057qib7 14340 14 is be VBZ cord-005453-4057qib7 14340 15 poorly poorly RB cord-005453-4057qib7 14340 16 represented represent VBN cord-005453-4057qib7 14340 17 in in IN cord-005453-4057qib7 14340 18 the the DT cord-005453-4057qib7 14340 19 standards standard NNS cord-005453-4057qib7 14340 20 of of IN cord-005453-4057qib7 14340 21 care care NN cord-005453-4057qib7 14340 22 concerning concern VBG cord-005453-4057qib7 14340 23 that that IN cord-005453-4057qib7 14340 24 older old JJR cord-005453-4057qib7 14340 25 adults adult NNS cord-005453-4057qib7 14340 26 undergoing undergo VBG cord-005453-4057qib7 14340 27 hematopoietic hematopoietic JJ cord-005453-4057qib7 14340 28 cell cell NN cord-005453-4057qib7 14340 29 transplant transplant NN cord-005453-4057qib7 14340 30 ( ( -LRB- cord-005453-4057qib7 14340 31 HCT HCT NNP cord-005453-4057qib7 14340 32 ) ) -RRB- cord-005453-4057qib7 14340 33 may may MD cord-005453-4057qib7 14340 34 experience experience VB cord-005453-4057qib7 14340 35 higher high JJR cord-005453-4057qib7 14340 36 transplant transplant NN cord-005453-4057qib7 14340 37 - - HYPH cord-005453-4057qib7 14340 38 related relate VBN cord-005453-4057qib7 14340 39 mortality mortality NN cord-005453-4057qib7 14340 40 ( ( -LRB- cord-005453-4057qib7 14340 41 TRM TRM NNP cord-005453-4057qib7 14340 42 ) ) -RRB- cord-005453-4057qib7 14340 43 . . . cord-005453-4057qib7 14341 1 Previous previous JJ cord-005453-4057qib7 14341 2 studies study NNS cord-005453-4057qib7 14341 3 have have VBP cord-005453-4057qib7 14341 4 demonstrated demonstrate VBN cord-005453-4057qib7 14341 5 that that IN cord-005453-4057qib7 14341 6 donor donor NN cord-005453-4057qib7 14341 7 age age NN cord-005453-4057qib7 14341 8 is be VBZ cord-005453-4057qib7 14341 9 vital vital JJ cord-005453-4057qib7 14341 10 for for IN cord-005453-4057qib7 14341 11 older old JJR cord-005453-4057qib7 14341 12 patients patient NNS cord-005453-4057qib7 14341 13 by by IN cord-005453-4057qib7 14341 14 affecting affect VBG cord-005453-4057qib7 14341 15 TRM TRM NNP cord-005453-4057qib7 14341 16 and and CC cord-005453-4057qib7 14341 17 survival survival NN cord-005453-4057qib7 14341 18 . . . cord-005453-4057qib7 14342 1 Accordingly accordingly RB cord-005453-4057qib7 14342 2 a a DT cord-005453-4057qib7 14342 3 relevant relevant JJ cord-005453-4057qib7 14342 4 question question NN cord-005453-4057qib7 14342 5 is be VBZ cord-005453-4057qib7 14342 6 whether whether IN cord-005453-4057qib7 14342 7 outcomes outcome NNS cord-005453-4057qib7 14342 8 can can MD cord-005453-4057qib7 14342 9 be be VB cord-005453-4057qib7 14342 10 improved improve VBN cord-005453-4057qib7 14342 11 with with IN cord-005453-4057qib7 14342 12 a a DT cord-005453-4057qib7 14342 13 younger young JJR cord-005453-4057qib7 14342 14 HLA HLA NNP cord-005453-4057qib7 14342 15 - - HYPH cord-005453-4057qib7 14342 16 haploidentical haploidentical JJ cord-005453-4057qib7 14342 17 offspring offspring NN cord-005453-4057qib7 14342 18 donor donor NN cord-005453-4057qib7 14342 19 rather rather RB cord-005453-4057qib7 14342 20 than than IN cord-005453-4057qib7 14342 21 an an DT cord-005453-4057qib7 14342 22 older old JJR cord-005453-4057qib7 14342 23 HLA HLA NNP cord-005453-4057qib7 14342 24 - - HYPH cord-005453-4057qib7 14342 25 matched match VBN cord-005453-4057qib7 14342 26 sibling sibling NN cord-005453-4057qib7 14342 27 ( ( -LRB- cord-005453-4057qib7 14342 28 MSD MSD NNP cord-005453-4057qib7 14342 29 ) ) -RRB- cord-005453-4057qib7 14342 30 . . . cord-005453-4057qib7 14343 1 In in IN cord-005453-4057qib7 14343 2 our -PRON- PRP$ cord-005453-4057qib7 14343 3 previous previous JJ cord-005453-4057qib7 14343 4 multi multi JJ cord-005453-4057qib7 14343 5 - - JJ cord-005453-4057qib7 14343 6 center center JJ cord-005453-4057qib7 14343 7 report report NN cord-005453-4057qib7 14343 8 under under IN cord-005453-4057qib7 14343 9 ATG+G ATG+G NNP cord-005453-4057qib7 14343 10 - - HYPH cord-005453-4057qib7 14343 11 CSF CSF NNP cord-005453-4057qib7 14343 12 based base VBN cord-005453-4057qib7 14343 13 protocol protocol NN cord-005453-4057qib7 14343 14 for for IN cord-005453-4057qib7 14343 15 haplo haplo NN cord-005453-4057qib7 14343 16 HCT HCT NNP cord-005453-4057qib7 14343 17 , , , cord-005453-4057qib7 14343 18 offspring offspring NN cord-005453-4057qib7 14343 19 donor donor NN cord-005453-4057qib7 14343 20 is be VBZ cord-005453-4057qib7 14343 21 correlated correlate VBN cord-005453-4057qib7 14343 22 with with IN cord-005453-4057qib7 14343 23 lower low JJR cord-005453-4057qib7 14343 24 TRM TRM NNP cord-005453-4057qib7 14343 25 and and CC cord-005453-4057qib7 14343 26 higher high JJR cord-005453-4057qib7 14343 27 leukemia leukemia NN cord-005453-4057qib7 14343 28 free free JJ cord-005453-4057qib7 14343 29 survival survival NN cord-005453-4057qib7 14343 30 ( ( -LRB- cord-005453-4057qib7 14343 31 LFS LFS NNP cord-005453-4057qib7 14343 32 ) ) -RRB- cord-005453-4057qib7 14343 33 as as IN cord-005453-4057qib7 14343 34 compared compare VBN cord-005453-4057qib7 14343 35 with with IN cord-005453-4057qib7 14343 36 older old JJR cord-005453-4057qib7 14343 37 MSD MSD NNP cord-005453-4057qib7 14343 38 in in IN cord-005453-4057qib7 14343 39 subgroup subgroup NN cord-005453-4057qib7 14343 40 analysis analysis NN cord-005453-4057qib7 14343 41 for for IN cord-005453-4057qib7 14343 42 recipients recipient NNS cord-005453-4057qib7 14343 43 > > NFP cord-005453-4057qib7 14343 44 50years 50year NNS cord-005453-4057qib7 14343 45 although although IN cord-005453-4057qib7 14343 46 it -PRON- PRP cord-005453-4057qib7 14343 47 did do VBD cord-005453-4057qib7 14343 48 not not RB cord-005453-4057qib7 14343 49 reach reach VB cord-005453-4057qib7 14343 50 statistical statistical JJ cord-005453-4057qib7 14343 51 significance significance NN cord-005453-4057qib7 14343 52 . . . cord-005453-4057qib7 14344 1 On on IN cord-005453-4057qib7 14344 2 the the DT cord-005453-4057qib7 14344 3 contrary contrary NN cord-005453-4057qib7 14344 4 , , , cord-005453-4057qib7 14344 5 in in IN cord-005453-4057qib7 14344 6 a a DT cord-005453-4057qib7 14344 7 recent recent JJ cord-005453-4057qib7 14344 8 report report NN cord-005453-4057qib7 14344 9 from from IN cord-005453-4057qib7 14344 10 EBMT EBMT NNP cord-005453-4057qib7 14344 11 and and CC cord-005453-4057qib7 14344 12 CIBMTR CIBMTR NNP cord-005453-4057qib7 14344 13 under under IN cord-005453-4057qib7 14344 14 PTCY PTCY NNP cord-005453-4057qib7 14344 15 modality modality NN cord-005453-4057qib7 14344 16 for for IN cord-005453-4057qib7 14344 17 haplo haplo NN cord-005453-4057qib7 14344 18 HCT HCT NNP cord-005453-4057qib7 14344 19 , , , cord-005453-4057qib7 14344 20 among among IN cord-005453-4057qib7 14344 21 patients patient NNS cord-005453-4057qib7 14344 22 aged age VBN cord-005453-4057qib7 14344 23 55 55 CD cord-005453-4057qib7 14344 24 to to TO cord-005453-4057qib7 14344 25 76 76 CD cord-005453-4057qib7 14344 26 years year NNS cord-005453-4057qib7 14344 27 , , , cord-005453-4057qib7 14344 28 despite despite IN cord-005453-4057qib7 14344 29 lower low JJR cord-005453-4057qib7 14344 30 chronic chronic JJ cord-005453-4057qib7 14344 31 graft graft NN cord-005453-4057qib7 14344 32 - - HYPH cord-005453-4057qib7 14344 33 versus versus IN cord-005453-4057qib7 14344 34 - - HYPH cord-005453-4057qib7 14344 35 host host NN cord-005453-4057qib7 14344 36 - - HYPH cord-005453-4057qib7 14344 37 disease disease NN cord-005453-4057qib7 14344 38 ( ( -LRB- cord-005453-4057qib7 14344 39 GVHD GVHD NNP cord-005453-4057qib7 14344 40 ) ) -RRB- cord-005453-4057qib7 14344 41 , , , cord-005453-4057qib7 14344 42 graft graft NN cord-005453-4057qib7 14344 43 failure failure NN cord-005453-4057qib7 14344 44 , , , cord-005453-4057qib7 14344 45 TRM TRM NNP cord-005453-4057qib7 14344 46 , , , cord-005453-4057qib7 14344 47 and and CC cord-005453-4057qib7 14344 48 overall overall JJ cord-005453-4057qib7 14344 49 mortality mortality NN cord-005453-4057qib7 14344 50 were be VBD cord-005453-4057qib7 14344 51 higher high JJR cord-005453-4057qib7 14344 52 after after IN cord-005453-4057qib7 14344 53 transplant transplant NN cord-005453-4057qib7 14344 54 from from IN cord-005453-4057qib7 14344 55 offspring offspring NN cord-005453-4057qib7 14344 56 compared compare VBN cord-005453-4057qib7 14344 57 with with IN cord-005453-4057qib7 14344 58 an an DT cord-005453-4057qib7 14344 59 MSD msd NN cord-005453-4057qib7 14344 60 although although IN cord-005453-4057qib7 14344 61 there there EX cord-005453-4057qib7 14344 62 were be VBD cord-005453-4057qib7 14344 63 differences difference NNS cord-005453-4057qib7 14344 64 in in IN cord-005453-4057qib7 14344 65 transplant transplant NN cord-005453-4057qib7 14344 66 platforms platform NNS cord-005453-4057qib7 14344 67 between between IN cord-005453-4057qib7 14344 68 the the DT cord-005453-4057qib7 14344 69 2 2 CD cord-005453-4057qib7 14344 70 groups group NNS cord-005453-4057qib7 14344 71 . . . cord-005453-4057qib7 14345 1 Methods method NNS cord-005453-4057qib7 14345 2 : : : cord-005453-4057qib7 14345 3 We -PRON- PRP cord-005453-4057qib7 14345 4 extended extend VBD cord-005453-4057qib7 14345 5 our -PRON- PRP$ cord-005453-4057qib7 14345 6 multi multi JJ cord-005453-4057qib7 14345 7 - - JJ cord-005453-4057qib7 14345 8 center center JJ cord-005453-4057qib7 14345 9 dataset dataset NN cord-005453-4057qib7 14345 10 and and CC cord-005453-4057qib7 14345 11 a a DT cord-005453-4057qib7 14345 12 matched match VBN cord-005453-4057qib7 14345 13 pair pair NN cord-005453-4057qib7 14345 14 analysis analysis NN cord-005453-4057qib7 14345 15 was be VBD cord-005453-4057qib7 14345 16 performed perform VBN cord-005453-4057qib7 14345 17 . . . cord-005453-4057qib7 14346 1 Outcomes outcome NNS cord-005453-4057qib7 14346 2 of of IN cord-005453-4057qib7 14346 3 142 142 CD cord-005453-4057qib7 14346 4 acute acute JJ cord-005453-4057qib7 14346 5 leukemia leukemia NN cord-005453-4057qib7 14346 6 patients patient NNS cord-005453-4057qib7 14346 7 ( ( -LRB- cord-005453-4057qib7 14346 8 > > XX cord-005453-4057qib7 14346 9 = = SYM cord-005453-4057qib7 14346 10 50 50 CD cord-005453-4057qib7 14346 11 years year NNS cord-005453-4057qib7 14346 12 ) ) -RRB- cord-005453-4057qib7 14346 13 transplanted transplant VBN cord-005453-4057qib7 14346 14 in in IN cord-005453-4057qib7 14346 15 CR1/ CR1/ NNP cord-005453-4057qib7 14346 16 CR2 CR2 NNP cord-005453-4057qib7 14346 17 who who WP cord-005453-4057qib7 14346 18 received receive VBD cord-005453-4057qib7 14346 19 HCT hct NN cord-005453-4057qib7 14346 20 from from IN cord-005453-4057qib7 14346 21 offspring offspring NN cord-005453-4057qib7 14346 22 ( ( -LRB- cord-005453-4057qib7 14346 23 n=57 n=57 NNP cord-005453-4057qib7 14346 24 ) ) -RRB- cord-005453-4057qib7 14346 25 or or CC cord-005453-4057qib7 14346 26 MSD MSD NNP cord-005453-4057qib7 14346 27 ( ( -LRB- cord-005453-4057qib7 14346 28 n=85 n=85 NN cord-005453-4057qib7 14346 29 ) ) -RRB- cord-005453-4057qib7 14346 30 between between IN cord-005453-4057qib7 14346 31 Jan Jan NNP cord-005453-4057qib7 14346 32 , , , cord-005453-4057qib7 14346 33 2013 2013 CD cord-005453-4057qib7 14346 34 and and CC cord-005453-4057qib7 14346 35 June June NNP cord-005453-4057qib7 14346 36 , , , cord-005453-4057qib7 14346 37 2017 2017 CD cord-005453-4057qib7 14346 38 present present JJ cord-005453-4057qib7 14346 39 in in IN cord-005453-4057qib7 14346 40 the the DT cord-005453-4057qib7 14346 41 multi multi JJ cord-005453-4057qib7 14346 42 - - JJ cord-005453-4057qib7 14346 43 center center JJ cord-005453-4057qib7 14346 44 database database NN cord-005453-4057qib7 14346 45 were be VBD cord-005453-4057qib7 14346 46 analyzed analyze VBN cord-005453-4057qib7 14346 47 . . . cord-005453-4057qib7 14347 1 Because because IN cord-005453-4057qib7 14347 2 the the DT cord-005453-4057qib7 14347 3 patient patient JJ cord-005453-4057qib7 14347 4 population population NN cord-005453-4057qib7 14347 5 was be VBD cord-005453-4057qib7 14347 6 small small JJ cord-005453-4057qib7 14347 7 , , , cord-005453-4057qib7 14347 8 a a DT cord-005453-4057qib7 14347 9 1:1 1:1 CD cord-005453-4057qib7 14347 10 ratio ratio NN cord-005453-4057qib7 14347 11 matched match VBN cord-005453-4057qib7 14347 12 pair pair NN cord-005453-4057qib7 14347 13 analysis analysis NN cord-005453-4057qib7 14347 14 was be VBD cord-005453-4057qib7 14347 15 implemented implement VBN cord-005453-4057qib7 14347 16 with with IN cord-005453-4057qib7 14347 17 the the DT cord-005453-4057qib7 14347 18 following following JJ cord-005453-4057qib7 14347 19 matching matching NN cord-005453-4057qib7 14347 20 factors factor NNS cord-005453-4057qib7 14347 21 : : : cord-005453-4057qib7 14347 22 underlying underlie VBG cord-005453-4057qib7 14347 23 disease disease NN cord-005453-4057qib7 14347 24 ( ( -LRB- cord-005453-4057qib7 14347 25 acute acute JJ cord-005453-4057qib7 14347 26 myeloid myeloid NN cord-005453-4057qib7 14347 27 leukemia leukemia NN cord-005453-4057qib7 14347 28 , , , cord-005453-4057qib7 14347 29 acute acute JJ cord-005453-4057qib7 14347 30 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 14347 31 leukemia leukemia NN cord-005453-4057qib7 14347 32 ) ) -RRB- cord-005453-4057qib7 14347 33 , , , cord-005453-4057qib7 14347 34 disease disease NN cord-005453-4057qib7 14347 35 status status NN cord-005453-4057qib7 14347 36 ( ( -LRB- cord-005453-4057qib7 14347 37 CR1 CR1 NNP cord-005453-4057qib7 14347 38 / / SYM cord-005453-4057qib7 14347 39 CR2 CR2 NNP cord-005453-4057qib7 14347 40 ) ) -RRB- cord-005453-4057qib7 14347 41 , , , cord-005453-4057qib7 14347 42 age age NN cord-005453-4057qib7 14347 43 and and CC cord-005453-4057qib7 14347 44 sex sex NN cord-005453-4057qib7 14347 45 of of IN cord-005453-4057qib7 14347 46 patients patient NNS cord-005453-4057qib7 14347 47 , , , cord-005453-4057qib7 14347 48 year year NN cord-005453-4057qib7 14347 49 of of IN cord-005453-4057qib7 14347 50 transplant transplant NN cord-005453-4057qib7 14347 51 , , , cord-005453-4057qib7 14347 52 blood blood NN cord-005453-4057qib7 14347 53 group group NN cord-005453-4057qib7 14347 54 incompatibilities incompatibility NNS cord-005453-4057qib7 14347 55 , , , cord-005453-4057qib7 14347 56 and and CC cord-005453-4057qib7 14347 57 sex sex NN cord-005453-4057qib7 14347 58 of of IN cord-005453-4057qib7 14347 59 donor donor NN cord-005453-4057qib7 14347 60 . . . cord-005453-4057qib7 14348 1 Results result NNS cord-005453-4057qib7 14348 2 : : : cord-005453-4057qib7 14349 1 We -PRON- PRP cord-005453-4057qib7 14349 2 were be VBD cord-005453-4057qib7 14349 3 able able JJ cord-005453-4057qib7 14349 4 to to TO cord-005453-4057qib7 14349 5 match match VB cord-005453-4057qib7 14349 6 41 41 CD cord-005453-4057qib7 14349 7 offspring offspring NN cord-005453-4057qib7 14349 8 with with IN cord-005453-4057qib7 14349 9 41 41 CD cord-005453-4057qib7 14349 10 MSD MSD NNP cord-005453-4057qib7 14349 11 patients patient NNS cord-005453-4057qib7 14349 12 . . . cord-005453-4057qib7 14350 1 The the DT cord-005453-4057qib7 14350 2 two two CD cord-005453-4057qib7 14350 3 matched match VBN cord-005453-4057qib7 14350 4 groups group NNS cord-005453-4057qib7 14350 5 were be VBD cord-005453-4057qib7 14350 6 comparable comparable JJ cord-005453-4057qib7 14350 7 in in IN cord-005453-4057qib7 14350 8 baseline baseline JJ cord-005453-4057qib7 14350 9 characteristics characteristic NNS cord-005453-4057qib7 14350 10 except except IN cord-005453-4057qib7 14350 11 for for IN cord-005453-4057qib7 14350 12 donor donor NN cord-005453-4057qib7 14350 13 age age NN cord-005453-4057qib7 14350 14 due due JJ cord-005453-4057qib7 14350 15 to to IN cord-005453-4057qib7 14350 16 the the DT cord-005453-4057qib7 14350 17 family family NN cord-005453-4057qib7 14350 18 relationship relationship NN cord-005453-4057qib7 14350 19 . . . cord-005453-4057qib7 14351 1 All all DT cord-005453-4057qib7 14351 2 patients patient NNS cord-005453-4057qib7 14351 3 achieved achieve VBD cord-005453-4057qib7 14351 4 myeloid myeloid JJ cord-005453-4057qib7 14351 5 recovery recovery NN cord-005453-4057qib7 14351 6 with with IN cord-005453-4057qib7 14351 7 a a DT cord-005453-4057qib7 14351 8 median median JJ cord-005453-4057qib7 14351 9 time time NN cord-005453-4057qib7 14351 10 of of IN cord-005453-4057qib7 14351 11 14d 14d NNS cord-005453-4057qib7 14351 12 and and CC cord-005453-4057qib7 14351 13 12d 12d NNS cord-005453-4057qib7 14351 14 for for IN cord-005453-4057qib7 14351 15 MSD MSD NNP cord-005453-4057qib7 14351 16 cohort cohort NN cord-005453-4057qib7 14351 17 and and CC cord-005453-4057qib7 14351 18 offspring offspring NN cord-005453-4057qib7 14351 19 group group NN cord-005453-4057qib7 14351 20 ( ( -LRB- cord-005453-4057qib7 14351 21 p=0.002 p=0.002 NNP cord-005453-4057qib7 14351 22 ) ) -RRB- cord-005453-4057qib7 14351 23 . . . cord-005453-4057qib7 14352 1 The the DT cord-005453-4057qib7 14352 2 100d 100d NNP cord-005453-4057qib7 14352 3 platelet platelet NN cord-005453-4057qib7 14352 4 recovery recovery NN cord-005453-4057qib7 14352 5 rate rate NN cord-005453-4057qib7 14352 6 was be VBD cord-005453-4057qib7 14352 7 95 95 CD cord-005453-4057qib7 14352 8 % % NN cord-005453-4057qib7 14352 9 in in IN cord-005453-4057qib7 14352 10 both both DT cord-005453-4057qib7 14352 11 groups group NNS cord-005453-4057qib7 14352 12 . . . cord-005453-4057qib7 14353 1 The the DT cord-005453-4057qib7 14353 2 cumulative cumulative JJ cord-005453-4057qib7 14353 3 incidence incidence NN cord-005453-4057qib7 14353 4 of of IN cord-005453-4057qib7 14353 5 grade grade NN cord-005453-4057qib7 14353 6 II II NNP cord-005453-4057qib7 14353 7 - - HYPH cord-005453-4057qib7 14353 8 IV IV NNP cord-005453-4057qib7 14353 9 acute acute JJ cord-005453-4057qib7 14353 10 GVHD GVHD NNP cord-005453-4057qib7 14353 11 in in IN cord-005453-4057qib7 14353 12 MSD MSD NNP cord-005453-4057qib7 14353 13 cohort cohort NN cord-005453-4057qib7 14353 14 was be VBD cord-005453-4057qib7 14353 15 significantly significantly RB cord-005453-4057qib7 14353 16 lower low JJR cord-005453-4057qib7 14353 17 than than IN cord-005453-4057qib7 14353 18 in in IN cord-005453-4057qib7 14353 19 offspring offspring NN cord-005453-4057qib7 14353 20 group group NN cord-005453-4057qib7 14353 21 ( ( -LRB- cord-005453-4057qib7 14353 22 12 12 CD cord-005453-4057qib7 14353 23 % % NN cord-005453-4057qib7 14353 24 vs vs IN cord-005453-4057qib7 14353 25 37 37 CD cord-005453-4057qib7 14353 26 % % NN cord-005453-4057qib7 14353 27 , , , cord-005453-4057qib7 14353 28 P=0.009 p=0.009 NN cord-005453-4057qib7 14353 29 ) ) -RRB- cord-005453-4057qib7 14353 30 while while IN cord-005453-4057qib7 14353 31 the the DT cord-005453-4057qib7 14353 32 incidence incidence NN cord-005453-4057qib7 14353 33 of of IN cord-005453-4057qib7 14353 34 chronic chronic JJ cord-005453-4057qib7 14353 35 GVHD GVHD NNP cord-005453-4057qib7 14353 36 in in IN cord-005453-4057qib7 14353 37 MSD MSD NNP cord-005453-4057qib7 14353 38 cohort cohort NN cord-005453-4057qib7 14353 39 was be VBD cord-005453-4057qib7 14353 40 significantly significantly RB cord-005453-4057qib7 14353 41 higher high JJR cord-005453-4057qib7 14353 42 than than IN cord-005453-4057qib7 14353 43 in in IN cord-005453-4057qib7 14353 44 offspring offspring NN cord-005453-4057qib7 14353 45 group group NN cord-005453-4057qib7 14353 46 ( ( -LRB- cord-005453-4057qib7 14353 47 51 51 CD cord-005453-4057qib7 14353 48 % % NN cord-005453-4057qib7 14353 49 vs vs IN cord-005453-4057qib7 14353 50 27 27 CD cord-005453-4057qib7 14353 51 % % NN cord-005453-4057qib7 14353 52 , , , cord-005453-4057qib7 14353 53 P=0.013 p=0.013 NN cord-005453-4057qib7 14353 54 ) ) -RRB- cord-005453-4057qib7 14353 55 . . . cord-005453-4057qib7 14354 1 The the DT cord-005453-4057qib7 14354 2 3-year 3-year CD cord-005453-4057qib7 14354 3 TRM TRM NNP cord-005453-4057qib7 14354 4 ( ( -LRB- cord-005453-4057qib7 14354 5 10 10 CD cord-005453-4057qib7 14354 6 % % NN cord-005453-4057qib7 14354 7 vs vs IN cord-005453-4057qib7 14354 8 31 31 CD cord-005453-4057qib7 14354 9 % % NN cord-005453-4057qib7 14354 10 , , , cord-005453-4057qib7 14354 11 P=0.028 p=0.028 NN cord-005453-4057qib7 14354 12 ) ) -RRB- cord-005453-4057qib7 14354 13 were be VBD cord-005453-4057qib7 14354 14 significantly significantly RB cord-005453-4057qib7 14354 15 lower low JJR cord-005453-4057qib7 14354 16 in in IN cord-005453-4057qib7 14354 17 offspring offspring NN cord-005453-4057qib7 14354 18 - - HYPH cord-005453-4057qib7 14354 19 HCT hct NN cord-005453-4057qib7 14354 20 compared compare VBN cord-005453-4057qib7 14354 21 with with IN cord-005453-4057qib7 14354 22 in in IN cord-005453-4057qib7 14354 23 MSD MSD NNP cord-005453-4057qib7 14354 24 - - HYPH cord-005453-4057qib7 14354 25 HCT hct NN cord-005453-4057qib7 14354 26 and and CC cord-005453-4057qib7 14354 27 relapse relapse NN cord-005453-4057qib7 14354 28 incidence incidence NN cord-005453-4057qib7 14354 29 was be VBD cord-005453-4057qib7 14354 30 comparable comparable JJ cord-005453-4057qib7 14354 31 ( ( -LRB- cord-005453-4057qib7 14354 32 8 8 CD cord-005453-4057qib7 14354 33 % % NN cord-005453-4057qib7 14354 34 vs vs IN cord-005453-4057qib7 14354 35 14 14 CD cord-005453-4057qib7 14354 36 % % NN cord-005453-4057qib7 14354 37 , , , cord-005453-4057qib7 14354 38 P=0.56 P=0.56 NNP cord-005453-4057qib7 14354 39 ) ) -RRB- cord-005453-4057qib7 14354 40 . . . cord-005453-4057qib7 14355 1 As as IN cord-005453-4057qib7 14355 2 a a DT cord-005453-4057qib7 14355 3 result result NN cord-005453-4057qib7 14355 4 , , , cord-005453-4057qib7 14355 5 the the DT cord-005453-4057qib7 14355 6 3-year 3-year JJ cord-005453-4057qib7 14355 7 overall overall JJ cord-005453-4057qib7 14355 8 survival survival NN cord-005453-4057qib7 14355 9 ( ( -LRB- cord-005453-4057qib7 14355 10 57 57 CD cord-005453-4057qib7 14355 11 % % NN cord-005453-4057qib7 14355 12 vs vs IN cord-005453-4057qib7 14355 13 82 82 CD cord-005453-4057qib7 14355 14 % % NN cord-005453-4057qib7 14355 15 , , , cord-005453-4057qib7 14355 16 P=0.033 P=0.033 NNP cord-005453-4057qib7 14355 17 ) ) -RRB- cord-005453-4057qib7 14355 18 and and CC cord-005453-4057qib7 14355 19 LFS LFS NNP cord-005453-4057qib7 14355 20 ( ( -LRB- cord-005453-4057qib7 14355 21 55 55 CD cord-005453-4057qib7 14355 22 % % NN cord-005453-4057qib7 14355 23 vs vs IN cord-005453-4057qib7 14355 24 82 82 CD cord-005453-4057qib7 14355 25 % % NN cord-005453-4057qib7 14355 26 , , , cord-005453-4057qib7 14355 27 P=0.024 p=0.024 NN cord-005453-4057qib7 14355 28 ) ) -RRB- cord-005453-4057qib7 14355 29 ( ( -LRB- cord-005453-4057qib7 14355 30 Figure figure NN cord-005453-4057qib7 14355 31 1 1 CD cord-005453-4057qib7 14355 32 ) ) -RRB- cord-005453-4057qib7 14355 33 were be VBD cord-005453-4057qib7 14355 34 significantly significantly RB cord-005453-4057qib7 14355 35 higher high JJR cord-005453-4057qib7 14355 36 in in IN cord-005453-4057qib7 14355 37 offspring offspring NN cord-005453-4057qib7 14355 38 - - HYPH cord-005453-4057qib7 14355 39 HCT hct NN cord-005453-4057qib7 14355 40 compared compare VBN cord-005453-4057qib7 14355 41 with with IN cord-005453-4057qib7 14355 42 in in IN cord-005453-4057qib7 14355 43 MSD MSD NNP cord-005453-4057qib7 14355 44 - - HYPH cord-005453-4057qib7 14355 45 HCT HCT NNP cord-005453-4057qib7 14355 46 . . . cord-005453-4057qib7 14356 1 In in IN cord-005453-4057qib7 14356 2 a a DT cord-005453-4057qib7 14356 3 multivariate multivariate JJ cord-005453-4057qib7 14356 4 analysis analysis NN cord-005453-4057qib7 14356 5 , , , cord-005453-4057qib7 14356 6 MSD MSD NNP cord-005453-4057qib7 14356 7 - - HYPH cord-005453-4057qib7 14356 8 HCT HCT NNP cord-005453-4057qib7 14356 9 remained remain VBD cord-005453-4057qib7 14356 10 a a DT cord-005453-4057qib7 14356 11 significant significant JJ cord-005453-4057qib7 14356 12 factor factor NN cord-005453-4057qib7 14356 13 for for IN cord-005453-4057qib7 14356 14 decreased decrease VBN cord-005453-4057qib7 14356 15 overall overall JJ cord-005453-4057qib7 14356 16 survival survival NN cord-005453-4057qib7 14356 17 ( ( -LRB- cord-005453-4057qib7 14356 18 HR HR NNP cord-005453-4057qib7 14356 19 2.791(1.141 2.791(1.141 CD cord-005453-4057qib7 14356 20 - - HYPH cord-005453-4057qib7 14356 21 6.824 6.824 CD cord-005453-4057qib7 14356 22 ) ) -RRB- cord-005453-4057qib7 14356 23 , , , cord-005453-4057qib7 14356 24 P=0.024 p=0.024 NN cord-005453-4057qib7 14356 25 ) ) -RRB- cord-005453-4057qib7 14356 26 by by IN cord-005453-4057qib7 14356 27 increased increase VBN cord-005453-4057qib7 14356 28 TRM TRM NNP cord-005453-4057qib7 14356 29 ) ) -RRB- cord-005453-4057qib7 14356 30 , , , cord-005453-4057qib7 14356 31 P= P= NNP cord-005453-4057qib7 14356 32 0.032 0.032 CD cord-005453-4057qib7 14356 33 ) ) -RRB- cord-005453-4057qib7 14357 1 in in IN cord-005453-4057qib7 14357 2 comparison comparison NN cord-005453-4057qib7 14357 3 with with IN cord-005453-4057qib7 14357 4 offspring offspring NN cord-005453-4057qib7 14357 5 - - HYPH cord-005453-4057qib7 14357 6 HCT hct NN cord-005453-4057qib7 14357 7 . . . cord-005453-4057qib7 14358 1 Conclusions conclusion NNS cord-005453-4057qib7 14358 2 : : : cord-005453-4057qib7 14359 1 These these DT cord-005453-4057qib7 14359 2 data datum NNS cord-005453-4057qib7 14359 3 favor favor VBP cord-005453-4057qib7 14359 4 a a DT cord-005453-4057qib7 14359 5 young young JJ cord-005453-4057qib7 14359 6 offspring offspring NN cord-005453-4057qib7 14359 7 over over IN cord-005453-4057qib7 14359 8 an an DT cord-005453-4057qib7 14359 9 older old JJR cord-005453-4057qib7 14359 10 MSD msd NN cord-005453-4057qib7 14359 11 in in IN cord-005453-4057qib7 14359 12 patients patient NNS cord-005453-4057qib7 14359 13 > > XX cord-005453-4057qib7 14359 14 50 50 CD cord-005453-4057qib7 14359 15 years year NNS cord-005453-4057qib7 14359 16 . . . cord-005453-4057qib7 14360 1 The the DT cord-005453-4057qib7 14360 2 current current JJ cord-005453-4057qib7 14360 3 analyses analysis NNS cord-005453-4057qib7 14360 4 confirm confirm VBP cord-005453-4057qib7 14360 5 non non JJ cord-005453-4057qib7 14360 6 - - JJ cord-005453-4057qib7 14360 7 HLA hla JJ cord-005453-4057qib7 14360 8 donor donor NN cord-005453-4057qib7 14360 9 characteristics characteristic NNS cord-005453-4057qib7 14360 10 , , , cord-005453-4057qib7 14360 11 rather rather RB cord-005453-4057qib7 14360 12 than than IN cord-005453-4057qib7 14360 13 HLA HLA NNP cord-005453-4057qib7 14360 14 disparity disparity NN cord-005453-4057qib7 14360 15 , , , cord-005453-4057qib7 14360 16 predominantly predominantly RB cord-005453-4057qib7 14360 17 influence influence VBP cord-005453-4057qib7 14360 18 survival survival NN cord-005453-4057qib7 14360 19 in in IN cord-005453-4057qib7 14360 20 older old JJR cord-005453-4057qib7 14360 21 acute acute JJ cord-005453-4057qib7 14360 22 leukemia leukemia NN cord-005453-4057qib7 14360 23 patients patient NNS cord-005453-4057qib7 14360 24 . . . cord-005453-4057qib7 14361 1 Validation validation NN cord-005453-4057qib7 14361 2 of of IN cord-005453-4057qib7 14361 3 these these DT cord-005453-4057qib7 14361 4 findings finding NNS cord-005453-4057qib7 14361 5 requires require VBZ cord-005453-4057qib7 14361 6 a a DT cord-005453-4057qib7 14361 7 prospective prospective JJ cord-005453-4057qib7 14361 8 trial trial NN cord-005453-4057qib7 14361 9 wherein wherein WRB cord-005453-4057qib7 14361 10 the the DT cord-005453-4057qib7 14361 11 transplant transplant NN cord-005453-4057qib7 14361 12 platforms platform NNS cord-005453-4057qib7 14361 13 can can MD cord-005453-4057qib7 14361 14 be be VB cord-005453-4057qib7 14361 15 closely closely RB cord-005453-4057qib7 14361 16 matched match VBN cord-005453-4057qib7 14361 17 . . . cord-005453-4057qib7 14362 1 [ [ -LRB- cord-005453-4057qib7 14362 2 [ [ -LRB- cord-005453-4057qib7 14362 3 P664 P664 NNP cord-005453-4057qib7 14362 4 Image image NN cord-005453-4057qib7 14362 5 ] ] -RRB- cord-005453-4057qib7 14362 6 1 1 CD cord-005453-4057qib7 14362 7 . . . cord-005453-4057qib7 14363 1 Figure1 Figure1 NNP cord-005453-4057qib7 14363 2 . . . cord-005453-4057qib7 14364 1 LFS LFS NNP cord-005453-4057qib7 14364 2 in in IN cord-005453-4057qib7 14364 3 offspring offspring NN cord-005453-4057qib7 14364 4 - - HYPH cord-005453-4057qib7 14364 5 HCT hct NN cord-005453-4057qib7 14364 6 compared compare VBN cord-005453-4057qib7 14364 7 with with IN cord-005453-4057qib7 14364 8 in in IN cord-005453-4057qib7 14364 9 MSD MSD NNP cord-005453-4057qib7 14364 10 - - HYPH cord-005453-4057qib7 14364 11 HCT HCT NNP cord-005453-4057qib7 14364 12 ( ( -LRB- cord-005453-4057qib7 14364 13 55 55 CD cord-005453-4057qib7 14364 14 % % NN cord-005453-4057qib7 14364 15 vs vs IN cord-005453-4057qib7 14364 16 82 82 CD cord-005453-4057qib7 14364 17 % % NN cord-005453-4057qib7 14364 18 , , , cord-005453-4057qib7 14364 19 P=0.024 p=0.024 NN cord-005453-4057qib7 14364 20 ) ) -RRB- cord-005453-4057qib7 14364 21 ] ] -RRB- cord-005453-4057qib7 14365 1 Disclosure disclosure NN cord-005453-4057qib7 14365 2 : : : cord-005453-4057qib7 14365 3 Nothing nothing NN cord-005453-4057qib7 14365 4 to to TO cord-005453-4057qib7 14365 5 declare declare VB cord-005453-4057qib7 14365 6 . . . cord-005453-4057qib7 14366 1 Impact impact NN cord-005453-4057qib7 14366 2 of of IN cord-005453-4057qib7 14366 3 sibling sibling NN cord-005453-4057qib7 14366 4 donor donor NN cord-005453-4057qib7 14366 5 - - HYPH cord-005453-4057qib7 14366 6 recipient recipient NN cord-005453-4057qib7 14366 7 sex sex NN cord-005453-4057qib7 14366 8 combinations combination NNS cord-005453-4057qib7 14366 9 on on IN cord-005453-4057qib7 14366 10 rejection rejection NN cord-005453-4057qib7 14366 11 after after IN cord-005453-4057qib7 14366 12 hla hla NNP cord-005453-4057qib7 14366 13 - - HYPH cord-005453-4057qib7 14366 14 matched match VBN cord-005453-4057qib7 14366 15 bone bone NN cord-005453-4057qib7 14366 16 marrow marrow NN cord-005453-4057qib7 14366 17 transplantation transplantation NN cord-005453-4057qib7 14366 18 for for IN cord-005453-4057qib7 14366 19 severe severe JJ cord-005453-4057qib7 14366 20 thalassemia thalassemia NN cord-005453-4057qib7 14366 21 1 1 CD cord-005453-4057qib7 14366 22 Cure2Children Cure2Children NNP cord-005453-4057qib7 14366 23 Foundation Foundation NNP cord-005453-4057qib7 14366 24 , , , cord-005453-4057qib7 14366 25 Florence Florence NNP cord-005453-4057qib7 14366 26 , , , cord-005453-4057qib7 14366 27 Italy Italy NNP cord-005453-4057qib7 14366 28 , , , cord-005453-4057qib7 14366 29 2 2 CD cord-005453-4057qib7 14366 30 Sankalp Sankalp NNP cord-005453-4057qib7 14366 31 India India NNP cord-005453-4057qib7 14366 32 Foundation Foundation NNP cord-005453-4057qib7 14366 33 , , , cord-005453-4057qib7 14366 34 Bangalore Bangalore NNP cord-005453-4057qib7 14366 35 , , , cord-005453-4057qib7 14366 36 India India NNP cord-005453-4057qib7 14366 37 , , , cord-005453-4057qib7 14366 38 3 3 CD cord-005453-4057qib7 14366 39 People People NNS cord-005453-4057qib7 14366 40 Tree Tree NNP cord-005453-4057qib7 14366 41 Hospitals Hospitals NNPS cord-005453-4057qib7 14366 42 , , , cord-005453-4057qib7 14366 43 Bangalore Bangalore NNP cord-005453-4057qib7 14366 44 , , , cord-005453-4057qib7 14366 45 India India NNP cord-005453-4057qib7 14366 46 , , , cord-005453-4057qib7 14366 47 4 4 CD cord-005453-4057qib7 14366 48 South South NNP cord-005453-4057qib7 14366 49 East East NNP cord-005453-4057qib7 14366 50 Asia Asia NNP cord-005453-4057qib7 14366 51 Institute Institute NNP cord-005453-4057qib7 14366 52 for for IN cord-005453-4057qib7 14366 53 Thalassemia Thalassemia NNP cord-005453-4057qib7 14366 54 , , , cord-005453-4057qib7 14366 55 Jaipur Jaipur NNP cord-005453-4057qib7 14366 56 , , , cord-005453-4057qib7 14366 57 India India NNP cord-005453-4057qib7 14366 58 , , , cord-005453-4057qib7 14366 59 5 5 CD cord-005453-4057qib7 14366 60 Pakistan Pakistan NNP cord-005453-4057qib7 14366 61 Institute Institute NNP cord-005453-4057qib7 14366 62 of of IN cord-005453-4057qib7 14366 63 Medical Medical NNP cord-005453-4057qib7 14366 64 Sciences Sciences NNPS cord-005453-4057qib7 14366 65 , , , cord-005453-4057qib7 14366 66 Islamabad Islamabad NNP cord-005453-4057qib7 14366 67 , , , cord-005453-4057qib7 14366 68 Pakistan Pakistan NNP cord-005453-4057qib7 14366 69 , , , cord-005453-4057qib7 14366 70 6 6 CD cord-005453-4057qib7 14366 71 Central Central NNP cord-005453-4057qib7 14366 72 Asiri Asiri NNP cord-005453-4057qib7 14366 73 Hospital Hospital NNP cord-005453-4057qib7 14366 74 , , , cord-005453-4057qib7 14366 75 Colombo Colombo NNP cord-005453-4057qib7 14366 76 , , , cord-005453-4057qib7 14366 77 Sri Sri NNP cord-005453-4057qib7 14366 78 Lanka Lanka NNP cord-005453-4057qib7 14366 79 , , , cord-005453-4057qib7 14366 80 7 7 CD cord-005453-4057qib7 14366 81 Nawaloka Nawaloka NNP cord-005453-4057qib7 14366 82 Hospital Hospital NNP cord-005453-4057qib7 14366 83 , , , cord-005453-4057qib7 14366 84 Colombo Colombo NNP cord-005453-4057qib7 14366 85 , , , cord-005453-4057qib7 14366 86 Sri Sri NNP cord-005453-4057qib7 14366 87 Lanka Lanka NNP cord-005453-4057qib7 14366 88 , , , cord-005453-4057qib7 14366 89 8 8 CD cord-005453-4057qib7 14366 90 Kokilaben Kokilaben NNP cord-005453-4057qib7 14366 91 Dhirubhani Dhirubhani NNP cord-005453-4057qib7 14366 92 Ambani Ambani NNP cord-005453-4057qib7 14366 93 Hospital Hospital NNP cord-005453-4057qib7 14366 94 , , , cord-005453-4057qib7 14366 95 Mumbai Mumbai NNP cord-005453-4057qib7 14366 96 , , , cord-005453-4057qib7 14367 1 India India NNP cord-005453-4057qib7 14367 2 Background Background NNP cord-005453-4057qib7 14367 3 : : : cord-005453-4057qib7 14368 1 Severe severe JJ cord-005453-4057qib7 14368 2 thalassemia thalassemia NN cord-005453-4057qib7 14368 3 ( ( -LRB- cord-005453-4057qib7 14368 4 ST ST NNP cord-005453-4057qib7 14368 5 ) ) -RRB- cord-005453-4057qib7 14368 6 , , , cord-005453-4057qib7 14368 7 i.e. i.e. FW cord-005453-4057qib7 14368 8 a a DT cord-005453-4057qib7 14368 9 thalassemia thalassemia NN cord-005453-4057qib7 14368 10 syndrome syndrome NN cord-005453-4057qib7 14368 11 with with IN cord-005453-4057qib7 14368 12 inability inability NN cord-005453-4057qib7 14368 13 to to TO cord-005453-4057qib7 14368 14 keep keep VB cord-005453-4057qib7 14368 15 spontaneous spontaneous JJ cord-005453-4057qib7 14368 16 hemoglobin hemoglobin NN cord-005453-4057qib7 14368 17 > > XX cord-005453-4057qib7 14368 18 7 7 CD cord-005453-4057qib7 14368 19 g g NN cord-005453-4057qib7 14368 20 / / SYM cord-005453-4057qib7 14368 21 dL dl NN cord-005453-4057qib7 14368 22 , , , cord-005453-4057qib7 14368 23 is be VBZ cord-005453-4057qib7 14368 24 a a DT cord-005453-4057qib7 14368 25 common common JJ cord-005453-4057qib7 14368 26 indication indication NN cord-005453-4057qib7 14368 27 for for IN cord-005453-4057qib7 14368 28 Bone Bone NNP cord-005453-4057qib7 14368 29 Marrow Marrow NNP cord-005453-4057qib7 14368 30 Transplantation Transplantation NNP cord-005453-4057qib7 14368 31 ( ( -LRB- cord-005453-4057qib7 14368 32 BMT BMT NNP cord-005453-4057qib7 14368 33 ) ) -RRB- cord-005453-4057qib7 14368 34 in in IN cord-005453-4057qib7 14368 35 children child NNS cord-005453-4057qib7 14368 36 in in IN cord-005453-4057qib7 14368 37 the the DT cord-005453-4057qib7 14368 38 Middle Middle NNP cord-005453-4057qib7 14368 39 East East NNP cord-005453-4057qib7 14368 40 and and CC cord-005453-4057qib7 14368 41 South South NNP cord-005453-4057qib7 14368 42 East East NNP cord-005453-4057qib7 14368 43 Asia Asia NNP cord-005453-4057qib7 14368 44 . . . cord-005453-4057qib7 14369 1 Sex sex NN cord-005453-4057qib7 14369 2 mismatch mismatch NN cord-005453-4057qib7 14369 3 has have VBZ cord-005453-4057qib7 14369 4 been be VBN cord-005453-4057qib7 14369 5 associated associate VBN cord-005453-4057qib7 14369 6 with with IN cord-005453-4057qib7 14369 7 increased increase VBN cord-005453-4057qib7 14369 8 risk risk NN cord-005453-4057qib7 14369 9 of of IN cord-005453-4057qib7 14369 10 solid solid JJ cord-005453-4057qib7 14369 11 organ organ NN cord-005453-4057qib7 14369 12 rejection rejection NN cord-005453-4057qib7 14369 13 but but CC cord-005453-4057qib7 14369 14 is be VBZ cord-005453-4057qib7 14369 15 not not RB cord-005453-4057qib7 14369 16 generally generally RB cord-005453-4057qib7 14369 17 considered consider VBN cord-005453-4057qib7 14369 18 an an DT cord-005453-4057qib7 14369 19 important important JJ cord-005453-4057qib7 14369 20 transplant transplant NN cord-005453-4057qib7 14369 21 - - HYPH cord-005453-4057qib7 14369 22 associated associate VBN cord-005453-4057qib7 14369 23 risk risk NN cord-005453-4057qib7 14369 24 factor factor NN cord-005453-4057qib7 14369 25 in in IN cord-005453-4057qib7 14369 26 the the DT cord-005453-4057qib7 14369 27 context context NN cord-005453-4057qib7 14369 28 of of IN cord-005453-4057qib7 14369 29 fully fully RB cord-005453-4057qib7 14369 30 matched match VBN cord-005453-4057qib7 14369 31 sibling sibling NN cord-005453-4057qib7 14369 32 BMT BMT NNP cord-005453-4057qib7 14369 33 for for IN cord-005453-4057qib7 14369 34 ST ST NNP cord-005453-4057qib7 14369 35 . . . cord-005453-4057qib7 14370 1 Methods method NNS cord-005453-4057qib7 14370 2 : : : cord-005453-4057qib7 14371 1 A a DT cord-005453-4057qib7 14371 2 total total NN cord-005453-4057qib7 14371 3 of of IN cord-005453-4057qib7 14371 4 154 154 CD cord-005453-4057qib7 14371 5 consecutive consecutive JJ cord-005453-4057qib7 14371 6 sibling sibling NN cord-005453-4057qib7 14371 7 bone bone NN cord-005453-4057qib7 14371 8 marrow marrow NN cord-005453-4057qib7 14371 9 transplants transplant NNS cord-005453-4057qib7 14371 10 carried carry VBN cord-005453-4057qib7 14371 11 out out RP cord-005453-4057qib7 14371 12 between between IN cord-005453-4057qib7 14371 13 January January NNP cord-005453-4057qib7 14371 14 2009 2009 CD cord-005453-4057qib7 14371 15 and and CC cord-005453-4057qib7 14371 16 April April NNP cord-005453-4057qib7 14371 17 2017 2017 CD cord-005453-4057qib7 14371 18 after after IN cord-005453-4057qib7 14371 19 conditioning condition VBG cord-005453-4057qib7 14371 20 with with IN cord-005453-4057qib7 14371 21 busulfan busulfan NN cord-005453-4057qib7 14371 22 ( ( -LRB- cord-005453-4057qib7 14371 23 14 14 CD cord-005453-4057qib7 14371 24 mg mg NNP cord-005453-4057qib7 14371 25 / / SYM cord-005453-4057qib7 14371 26 kg kg NNP cord-005453-4057qib7 14371 27 oral oral JJ cord-005453-4057qib7 14371 28 , , , cord-005453-4057qib7 14371 29 not not RB cord-005453-4057qib7 14371 30 adjusted adjust VBN cord-005453-4057qib7 14371 31 to to IN cord-005453-4057qib7 14371 32 serum serum NN cord-005453-4057qib7 14371 33 levels level NNS cord-005453-4057qib7 14371 34 ) ) -RRB- cord-005453-4057qib7 14371 35 and and CC cord-005453-4057qib7 14371 36 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14371 37 ( ( -LRB- cord-005453-4057qib7 14371 38 200 200 CD cord-005453-4057qib7 14371 39 mg mg NNP cord-005453-4057qib7 14371 40 / / SYM cord-005453-4057qib7 14371 41 kg kg NNP cord-005453-4057qib7 14371 42 ) ) -RRB- cord-005453-4057qib7 14371 43 ( ( -LRB- cord-005453-4057qib7 14371 44 2 2 CD cord-005453-4057qib7 14371 45 patients patient NNS cord-005453-4057qib7 14371 46 ) ) -RRB- cord-005453-4057qib7 14372 1 in in IN cord-005453-4057qib7 14372 2 addition addition NN cord-005453-4057qib7 14372 3 to to IN cord-005453-4057qib7 14372 4 either either DT cord-005453-4057qib7 14372 5 thiotepa thiotepa NNS cord-005453-4057qib7 14372 6 ( ( -LRB- cord-005453-4057qib7 14372 7 10 10 CD cord-005453-4057qib7 14372 8 mg mg NNP cord-005453-4057qib7 14372 9 / / SYM cord-005453-4057qib7 14372 10 kg kg NNP cord-005453-4057qib7 14372 11 ) ) -RRB- cord-005453-4057qib7 14372 12 ( ( -LRB- cord-005453-4057qib7 14372 13 49 49 CD cord-005453-4057qib7 14372 14 patients patient NNS cord-005453-4057qib7 14372 15 ) ) -RRB- cord-005453-4057qib7 14372 16 , , , cord-005453-4057qib7 14372 17 or or CC cord-005453-4057qib7 14372 18 anti anti JJ cord-005453-4057qib7 14372 19 - - JJ cord-005453-4057qib7 14372 20 thymocyte thymocyte JJ cord-005453-4057qib7 14372 21 globulin globulin NN cord-005453-4057qib7 14372 22 ( ( -LRB- cord-005453-4057qib7 14373 1 Genzyme Genzyme NNP cord-005453-4057qib7 14373 2 4 4 CD cord-005453-4057qib7 14373 3 mg/ mg/ NN cord-005453-4057qib7 14373 4 kg kg NNP cord-005453-4057qib7 14373 5 or or CC cord-005453-4057qib7 14373 6 Fresenius Fresenius NNP cord-005453-4057qib7 14373 7 16 16 CD cord-005453-4057qib7 14374 1 mg mg NNP cord-005453-4057qib7 14374 2 / / SYM cord-005453-4057qib7 14374 3 kg kg NNS cord-005453-4057qib7 14374 4 on on IN cord-005453-4057qib7 14374 5 days day NNS cord-005453-4057qib7 14374 6 -12 -12 CD cord-005453-4057qib7 14374 7 to to IN cord-005453-4057qib7 14374 8 -10 -10 NN cord-005453-4057qib7 14374 9 ) ) -RRB- cord-005453-4057qib7 14375 1 ( ( -LRB- cord-005453-4057qib7 14375 2 92 92 CD cord-005453-4057qib7 14375 3 patients patient NNS cord-005453-4057qib7 14375 4 ) ) -RRB- cord-005453-4057qib7 14375 5 and and CC cord-005453-4057qib7 14375 6 Fludarabine Fludarabine NNP cord-005453-4057qib7 14375 7 150 150 CD cord-005453-4057qib7 14375 8 mg mg NNP cord-005453-4057qib7 14375 9 / / SYM cord-005453-4057qib7 14375 10 m m NN cord-005453-4057qib7 14375 11 2 2 CD cord-005453-4057qib7 14375 12 ( ( -LRB- cord-005453-4057qib7 14375 13 11 11 CD cord-005453-4057qib7 14375 14 patients patient NNS cord-005453-4057qib7 14375 15 ) ) -RRB- cord-005453-4057qib7 14375 16 were be VBD cord-005453-4057qib7 14375 17 analysed analyse VBN cord-005453-4057qib7 14375 18 . . . cord-005453-4057qib7 14376 1 All all DT cord-005453-4057qib7 14376 2 cases case NNS cord-005453-4057qib7 14376 3 received receive VBD cord-005453-4057qib7 14376 4 cyclosporine cyclosporine NN cord-005453-4057qib7 14376 5 and and CC cord-005453-4057qib7 14376 6 methotrexate methotrexate NNP cord-005453-4057qib7 14376 7 or or CC cord-005453-4057qib7 14376 8 mycophenolate mycophenolate NNP cord-005453-4057qib7 14376 9 mofetil mofetil NNP cord-005453-4057qib7 14376 10 as as IN cord-005453-4057qib7 14376 11 GVHD GVHD NNP cord-005453-4057qib7 14376 12 / / SYM cord-005453-4057qib7 14376 13 rejection rejection NN cord-005453-4057qib7 14376 14 prophylaxis prophylaxis NN cord-005453-4057qib7 14376 15 . . . cord-005453-4057qib7 14377 1 In in IN cord-005453-4057qib7 14377 2 the the DT cord-005453-4057qib7 14377 3 thiotepa thiotepa JJ cord-005453-4057qib7 14377 4 group group NN cord-005453-4057qib7 14377 5 methylprednisolone methylprednisolone NN cord-005453-4057qib7 14377 6 at at IN cord-005453-4057qib7 14377 7 0.5 0.5 CD cord-005453-4057qib7 14377 8 mg mg NNP cord-005453-4057qib7 14377 9 / / SYM cord-005453-4057qib7 14377 10 kg kg NNP cord-005453-4057qib7 14377 11 / / SYM cord-005453-4057qib7 14377 12 day day NN cord-005453-4057qib7 14377 13 was be VBD cord-005453-4057qib7 14377 14 also also RB cord-005453-4057qib7 14377 15 used use VBN cord-005453-4057qib7 14377 16 during during IN cord-005453-4057qib7 14377 17 the the DT cord-005453-4057qib7 14377 18 first first JJ cord-005453-4057qib7 14377 19 30 30 CD cord-005453-4057qib7 14377 20 days day NNS cord-005453-4057qib7 14377 21 after after IN cord-005453-4057qib7 14377 22 BMT BMT NNP cord-005453-4057qib7 14377 23 ( ( -LRB- cord-005453-4057qib7 14377 24 Lucarelli Lucarelli NNP cord-005453-4057qib7 14377 25 protocol protocol NN cord-005453-4057qib7 14377 26 6i 6i CD cord-005453-4057qib7 14377 27 ) ) -RRB- cord-005453-4057qib7 14377 28 . . . cord-005453-4057qib7 14378 1 Bone bone NN cord-005453-4057qib7 14378 2 marrow marrow NN cord-005453-4057qib7 14378 3 was be VBD cord-005453-4057qib7 14378 4 the the DT cord-005453-4057qib7 14378 5 source source NN cord-005453-4057qib7 14378 6 of of IN cord-005453-4057qib7 14378 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 14378 8 stem stem NN cord-005453-4057qib7 14378 9 cells cell NNS cord-005453-4057qib7 14378 10 in in IN cord-005453-4057qib7 14378 11 all all DT cord-005453-4057qib7 14378 12 cases case NNS cord-005453-4057qib7 14378 13 , , , cord-005453-4057qib7 14378 14 in in IN cord-005453-4057qib7 14378 15 the the DT cord-005453-4057qib7 14378 16 ATG ATG NNP cord-005453-4057qib7 14378 17 group group NN cord-005453-4057qib7 14378 18 it -PRON- PRP cord-005453-4057qib7 14378 19 was be VBD cord-005453-4057qib7 14378 20 G G NNP cord-005453-4057qib7 14378 21 - - HYPH cord-005453-4057qib7 14378 22 CSFprimed CSFprimed NNP cord-005453-4057qib7 14378 23 ( ( -LRB- cord-005453-4057qib7 14378 24 5 5 CD cord-005453-4057qib7 14378 25 μg μg NNP cord-005453-4057qib7 14378 26 / / SYM cord-005453-4057qib7 14378 27 kg kg NN cord-005453-4057qib7 14378 28 / / SYM cord-005453-4057qib7 14378 29 dose dose NN cord-005453-4057qib7 14378 30 twice twice RB cord-005453-4057qib7 14378 31 daily daily RB cord-005453-4057qib7 14378 32 for for IN cord-005453-4057qib7 14378 33 3 3 CD cord-005453-4057qib7 14378 34 to to TO cord-005453-4057qib7 14378 35 5 5 CD cord-005453-4057qib7 14378 36 days day NNS cord-005453-4057qib7 14378 37 prior prior RB cord-005453-4057qib7 14378 38 to to IN cord-005453-4057qib7 14378 39 harvest harvest NN cord-005453-4057qib7 14378 40 ) ) -RRB- cord-005453-4057qib7 14378 41 . . . cord-005453-4057qib7 14379 1 All all DT cord-005453-4057qib7 14379 2 patients patient NNS cord-005453-4057qib7 14379 3 were be VBD cord-005453-4057qib7 14379 4 considered consider VBN cord-005453-4057qib7 14379 5 low low JJ cord-005453-4057qib7 14379 6 risk risk NN cord-005453-4057qib7 14379 7 based base VBN cord-005453-4057qib7 14379 8 on on IN cord-005453-4057qib7 14379 9 liver liver NN cord-005453-4057qib7 14379 10 size size NN cord-005453-4057qib7 14379 11 < < XX cord-005453-4057qib7 14379 12 2 2 CD cord-005453-4057qib7 14379 13 cm cm NNP cord-005453-4057qib7 14379 14 from from IN cord-005453-4057qib7 14379 15 costal costal JJ cord-005453-4057qib7 14379 16 margin margin NN cord-005453-4057qib7 14379 17 and and CC cord-005453-4057qib7 14379 18 age age NN cord-005453-4057qib7 14379 19 less less JJR cord-005453-4057qib7 14379 20 than than IN cord-005453-4057qib7 14379 21 15 15 CD cord-005453-4057qib7 14379 22 years year NNS cord-005453-4057qib7 14379 23 ( ( -LRB- cord-005453-4057qib7 14379 24 median median NN cord-005453-4057qib7 14379 25 4.2 4.2 CD cord-005453-4057qib7 14379 26 years year NNS cord-005453-4057qib7 14379 27 , , , cord-005453-4057qib7 14379 28 range range VBP cord-005453-4057qib7 14379 29 0.9 0.9 CD cord-005453-4057qib7 14379 30 to to IN cord-005453-4057qib7 14379 31 14.5 14.5 CD cord-005453-4057qib7 14379 32 ) ) -RRB- cord-005453-4057qib7 14379 33 , , , cord-005453-4057qib7 14379 34 all all DT cord-005453-4057qib7 14379 35 sibling sibling NN cord-005453-4057qib7 14379 36 pairs pair NNS cord-005453-4057qib7 14379 37 where where WRB cord-005453-4057qib7 14379 38 HLA HLA NNP cord-005453-4057qib7 14379 39 - - HYPH cord-005453-4057qib7 14379 40 compatible compatible JJ cord-005453-4057qib7 14379 41 . . . cord-005453-4057qib7 14380 1 Results result NNS cord-005453-4057qib7 14380 2 : : : cord-005453-4057qib7 14381 1 [ [ -LRB- cord-005453-4057qib7 14381 2 [ [ -LRB- cord-005453-4057qib7 14381 3 P665 P665 NNP cord-005453-4057qib7 14381 4 Image image NN cord-005453-4057qib7 14381 5 ] ] -RRB- cord-005453-4057qib7 14381 6 1 1 CD cord-005453-4057qib7 14381 7 . . . cord-005453-4057qib7 14382 1 Sibling sibling NN cord-005453-4057qib7 14382 2 donor donor NN cord-005453-4057qib7 14382 3 - - HYPH cord-005453-4057qib7 14382 4 recipient recipient NN cord-005453-4057qib7 14382 5 sex sex NN cord-005453-4057qib7 14382 6 combinations combination NNS cord-005453-4057qib7 14382 7 . . . cord-005453-4057qib7 14382 8 ] ] -RRB- cord-005453-4057qib7 14383 1 The the DT cord-005453-4057qib7 14383 2 lowest low JJS cord-005453-4057qib7 14383 3 rejection rejection NN cord-005453-4057qib7 14383 4 rate rate NN cord-005453-4057qib7 14383 5 ( ( -LRB- cord-005453-4057qib7 14383 6 5 5 CD cord-005453-4057qib7 14383 7 % % NN cord-005453-4057qib7 14383 8 ) ) -RRB- cord-005453-4057qib7 14383 9 was be VBD cord-005453-4057qib7 14383 10 observed observe VBN cord-005453-4057qib7 14383 11 in in IN cord-005453-4057qib7 14383 12 the the DT cord-005453-4057qib7 14383 13 Sister Sister NNP cord-005453-4057qib7 14383 14 to to IN cord-005453-4057qib7 14383 15 Sister Sister NNP cord-005453-4057qib7 14383 16 ( ( -LRB- cord-005453-4057qib7 14383 17 S2S S2S NNP cord-005453-4057qib7 14383 18 ) ) -RRB- cord-005453-4057qib7 14383 19 group group NN cord-005453-4057qib7 14383 20 of of IN cord-005453-4057qib7 14383 21 24 24 CD cord-005453-4057qib7 14383 22 cases case NNS cord-005453-4057qib7 14383 23 , , , cord-005453-4057qib7 14383 24 followed follow VBN cord-005453-4057qib7 14383 25 by by IN cord-005453-4057qib7 14383 26 Brother Brother NNP cord-005453-4057qib7 14383 27 to to IN cord-005453-4057qib7 14383 28 Brother Brother NNP cord-005453-4057qib7 14383 29 ( ( -LRB- cord-005453-4057qib7 14383 30 B2B B2B NNP cord-005453-4057qib7 14383 31 ) ) -RRB- cord-005453-4057qib7 14383 32 group group NN cord-005453-4057qib7 14383 33 of of IN cord-005453-4057qib7 14383 34 40 40 CD cord-005453-4057qib7 14383 35 cases case NNS cord-005453-4057qib7 14383 36 with with IN cord-005453-4057qib7 14383 37 11 11 CD cord-005453-4057qib7 14383 38 % % NN cord-005453-4057qib7 14383 39 . . . cord-005453-4057qib7 14384 1 In in IN cord-005453-4057qib7 14384 2 the the DT cord-005453-4057qib7 14384 3 Sister Sister NNP cord-005453-4057qib7 14384 4 to to IN cord-005453-4057qib7 14384 5 Brother Brother NNP cord-005453-4057qib7 14384 6 ( ( -LRB- cord-005453-4057qib7 14384 7 S2B s2b NN cord-005453-4057qib7 14384 8 ) ) -RRB- cord-005453-4057qib7 14384 9 group group NN cord-005453-4057qib7 14384 10 of of IN cord-005453-4057qib7 14384 11 59 59 CD cord-005453-4057qib7 14384 12 cases case NNS cord-005453-4057qib7 14384 13 , , , cord-005453-4057qib7 14384 14 rejection rejection NN cord-005453-4057qib7 14384 15 rate rate NN cord-005453-4057qib7 14384 16 was be VBD cord-005453-4057qib7 14384 17 21 21 CD cord-005453-4057qib7 14384 18 % % NN cord-005453-4057qib7 14384 19 , , , cord-005453-4057qib7 14384 20 and and CC cord-005453-4057qib7 14384 21 26 26 CD cord-005453-4057qib7 14384 22 % % NN cord-005453-4057qib7 14384 23 in in IN cord-005453-4057qib7 14384 24 the the DT cord-005453-4057qib7 14384 25 Brother Brother NNP cord-005453-4057qib7 14384 26 to to IN cord-005453-4057qib7 14384 27 Sister Sister NNP cord-005453-4057qib7 14384 28 ( ( -LRB- cord-005453-4057qib7 14384 29 B2S B2S NNP cord-005453-4057qib7 14384 30 ) ) -RRB- cord-005453-4057qib7 14384 31 group group NNP cord-005453-4057qib7 14384 32 of of IN cord-005453-4057qib7 14384 33 31 31 CD cord-005453-4057qib7 14384 34 cases case NNS cord-005453-4057qib7 14384 35 . . . cord-005453-4057qib7 14385 1 On on IN cord-005453-4057qib7 14385 2 univariate univariate JJ cord-005453-4057qib7 14385 3 analysis analysis NN cord-005453-4057qib7 14385 4 the the DT cord-005453-4057qib7 14385 5 only only JJ cord-005453-4057qib7 14385 6 significant significant JJ cord-005453-4057qib7 14385 7 difference difference NN cord-005453-4057qib7 14385 8 at at IN cord-005453-4057qib7 14385 9 the the DT cord-005453-4057qib7 14385 10 P p NN cord-005453-4057qib7 14385 11 0.05 0.05 CD cord-005453-4057qib7 14385 12 level level NN cord-005453-4057qib7 14385 13 by by IN cord-005453-4057qib7 14385 14 log log NN cord-005453-4057qib7 14385 15 rank rank NN cord-005453-4057qib7 14385 16 test test NN cord-005453-4057qib7 14385 17 was be VBD cord-005453-4057qib7 14385 18 B2S B2S NNP cord-005453-4057qib7 14385 19 vs. vs. FW cord-005453-4057qib7 14385 20 S2S S2S NNP cord-005453-4057qib7 14385 21 groups group NNS cord-005453-4057qib7 14385 22 ( ( -LRB- cord-005453-4057qib7 14385 23 rejection rejection NN cord-005453-4057qib7 14385 24 proportions proportion NNS cord-005453-4057qib7 14385 25 of of IN cord-005453-4057qib7 14385 26 26 26 CD cord-005453-4057qib7 14385 27 % % NN cord-005453-4057qib7 14385 28 and and CC cord-005453-4057qib7 14385 29 5 5 CD cord-005453-4057qib7 14385 30 % % NN cord-005453-4057qib7 14385 31 respectively respectively RB cord-005453-4057qib7 14385 32 ) ) -RRB- cord-005453-4057qib7 14385 33 . . . cord-005453-4057qib7 14386 1 Interestingly interestingly RB cord-005453-4057qib7 14386 2 , , , cord-005453-4057qib7 14386 3 all all DT cord-005453-4057qib7 14386 4 3 3 CD cord-005453-4057qib7 14386 5 patients patient NNS cord-005453-4057qib7 14386 6 with with IN cord-005453-4057qib7 14386 7 rejection rejection NN cord-005453-4057qib7 14386 8 and and CC cord-005453-4057qib7 14386 9 persistent persistent JJ cord-005453-4057qib7 14386 10 pancytopenia pancytopenia NNP cord-005453-4057qib7 14386 11 were be VBD cord-005453-4057qib7 14386 12 female female JJ cord-005453-4057qib7 14386 13 recipients recipient NNS cord-005453-4057qib7 14386 14 of of IN cord-005453-4057qib7 14386 15 male male JJ cord-005453-4057qib7 14386 16 grafts graft NNS cord-005453-4057qib7 14386 17 . . . cord-005453-4057qib7 14387 1 Conclusions conclusion NNS cord-005453-4057qib7 14387 2 : : : cord-005453-4057qib7 14388 1 Even even RB cord-005453-4057qib7 14388 2 though though IN cord-005453-4057qib7 14388 3 several several JJ cord-005453-4057qib7 14388 4 preparative preparative JJ cord-005453-4057qib7 14388 5 regimens regimen NNS cord-005453-4057qib7 14388 6 were be VBD cord-005453-4057qib7 14388 7 employed employ VBN cord-005453-4057qib7 14388 8 over over IN cord-005453-4057qib7 14388 9 an an DT cord-005453-4057qib7 14388 10 8-year 8-year JJ cord-005453-4057qib7 14388 11 period period NN cord-005453-4057qib7 14388 12 , , , cord-005453-4057qib7 14388 13 our -PRON- PRP$ cord-005453-4057qib7 14388 14 data datum NNS cord-005453-4057qib7 14388 15 suggests suggest VBZ cord-005453-4057qib7 14388 16 that that IN cord-005453-4057qib7 14388 17 sex sex NN cord-005453-4057qib7 14388 18 mismatch mismatch NN cord-005453-4057qib7 14388 19 among among IN cord-005453-4057qib7 14388 20 compatible compatible JJ cord-005453-4057qib7 14388 21 siblings sibling NNS cord-005453-4057qib7 14388 22 should should MD cord-005453-4057qib7 14388 23 be be VB cord-005453-4057qib7 14388 24 considered consider VBN cord-005453-4057qib7 14388 25 as as IN cord-005453-4057qib7 14388 26 a a DT cord-005453-4057qib7 14388 27 relevant relevant JJ cord-005453-4057qib7 14388 28 variable variable NN cord-005453-4057qib7 14388 29 related relate VBN cord-005453-4057qib7 14388 30 to to IN cord-005453-4057qib7 14388 31 BMT BMT NNP cord-005453-4057qib7 14388 32 decisionmaking decisionmaking NN cord-005453-4057qib7 14388 33 . . . cord-005453-4057qib7 14389 1 We -PRON- PRP cord-005453-4057qib7 14389 2 also also RB cord-005453-4057qib7 14389 3 recommend recommend VBP cord-005453-4057qib7 14389 4 to to TO cord-005453-4057qib7 14389 5 consider consider VB cord-005453-4057qib7 14389 6 autologous autologous JJ cord-005453-4057qib7 14389 7 back back RB cord-005453-4057qib7 14389 8 up up RP cord-005453-4057qib7 14389 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 14389 10 stem stem NN cord-005453-4057qib7 14389 11 cell cell NN cord-005453-4057qib7 14389 12 collection collection NN cord-005453-4057qib7 14389 13 and and CC cord-005453-4057qib7 14389 14 storage storage NN cord-005453-4057qib7 14389 15 in in IN cord-005453-4057qib7 14389 16 sibling sibling NN cord-005453-4057qib7 14389 17 sex sex NN cord-005453-4057qib7 14389 18 mismatched mismatch VBN cord-005453-4057qib7 14389 19 transplants transplant NNS cord-005453-4057qib7 14389 20 , , , cord-005453-4057qib7 14389 21 particularly particularly RB cord-005453-4057qib7 14389 22 in in IN cord-005453-4057qib7 14389 23 brother brother NN cord-005453-4057qib7 14389 24 to to IN cord-005453-4057qib7 14389 25 sister sister NN cord-005453-4057qib7 14389 26 BMTs BMTs NNP cord-005453-4057qib7 14389 27 . . . cord-005453-4057qib7 14390 1 Same same JJ cord-005453-4057qib7 14390 2 - - HYPH cord-005453-4057qib7 14390 3 sex sex NN cord-005453-4057qib7 14390 4 fully fully RB cord-005453-4057qib7 14390 5 matched match VBD cord-005453-4057qib7 14390 6 related relate VBN cord-005453-4057qib7 14390 7 BMT BMT NNP cord-005453-4057qib7 14390 8 for for IN cord-005453-4057qib7 14390 9 severe severe JJ cord-005453-4057qib7 14390 10 thalassemia thalassemia NN cord-005453-4057qib7 14390 11 might may MD cord-005453-4057qib7 14390 12 be be VB cord-005453-4057qib7 14390 13 the the DT cord-005453-4057qib7 14390 14 best good JJS cord-005453-4057qib7 14390 15 scenario scenario NN cord-005453-4057qib7 14390 16 in in IN cord-005453-4057qib7 14390 17 which which WDT cord-005453-4057qib7 14390 18 reducedintensity reducedintensity NN cord-005453-4057qib7 14390 19 preparation preparation NN cord-005453-4057qib7 14390 20 strategies strategy NNS cord-005453-4057qib7 14390 21 aiming aim VBG cord-005453-4057qib7 14390 22 at at IN cord-005453-4057qib7 14390 23 maximizing maximize VBG cord-005453-4057qib7 14390 24 fertility fertility NN cord-005453-4057qib7 14390 25 preservation preservation NN cord-005453-4057qib7 14390 26 might may MD cord-005453-4057qib7 14390 27 be be VB cord-005453-4057qib7 14390 28 explored explore VBN cord-005453-4057qib7 14390 29 . . . cord-005453-4057qib7 14391 1 Disclosure disclosure NN cord-005453-4057qib7 14391 2 : : : cord-005453-4057qib7 14391 3 Nothing nothing NN cord-005453-4057qib7 14391 4 to to TO cord-005453-4057qib7 14391 5 declare declare VB cord-005453-4057qib7 14391 6 . . . cord-005453-4057qib7 14392 1 Outcomes outcome NNS cord-005453-4057qib7 14392 2 of of IN cord-005453-4057qib7 14392 3 T t NN cord-005453-4057qib7 14392 4 - - HYPH cord-005453-4057qib7 14392 5 cell cell NN cord-005453-4057qib7 14392 6 replete replete JJ cord-005453-4057qib7 14392 7 hematopoietic hematopoietic JJ cord-005453-4057qib7 14392 8 cell cell NN cord-005453-4057qib7 14392 9 transplantation transplantation NN cord-005453-4057qib7 14392 10 from from IN cord-005453-4057qib7 14392 11 mismatched mismatched JJ cord-005453-4057qib7 14392 12 related related JJ cord-005453-4057qib7 14392 13 or or CC cord-005453-4057qib7 14392 14 unrelated unrelated JJ cord-005453-4057qib7 14392 15 donors donor NNS cord-005453-4057qib7 14392 16 using use VBG cord-005453-4057qib7 14392 17 high high JJ cord-005453-4057qib7 14392 18 dose dose NN cord-005453-4057qib7 14392 19 post post JJ cord-005453-4057qib7 14392 20 - - JJ cord-005453-4057qib7 14392 21 transplant transplant NN cord-005453-4057qib7 14392 22 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14392 23 based base VBN cord-005453-4057qib7 14392 24 GVHD GVHD NNP cord-005453-4057qib7 14392 25 prophylaxis prophylaxis NN cord-005453-4057qib7 14392 26 Background background NN cord-005453-4057qib7 14392 27 : : : cord-005453-4057qib7 14393 1 High high JJ cord-005453-4057qib7 14393 2 dose dose NN cord-005453-4057qib7 14393 3 post post JJ cord-005453-4057qib7 14393 4 - - JJ cord-005453-4057qib7 14393 5 transplant transplant NN cord-005453-4057qib7 14393 6 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14393 7 ( ( -LRB- cord-005453-4057qib7 14393 8 ptCy ptcy RB cord-005453-4057qib7 14393 9 ) ) -RRB- cord-005453-4057qib7 14393 10 based base VBN cord-005453-4057qib7 14393 11 GvHD GvHD NNP cord-005453-4057qib7 14393 12 prophylaxis prophylaxis NN cord-005453-4057qib7 14393 13 overcomes overcome VBZ cord-005453-4057qib7 14393 14 immunological immunological JJ cord-005453-4057qib7 14393 15 barriers barrier NNS cord-005453-4057qib7 14393 16 in in IN cord-005453-4057qib7 14393 17 HLA HLA NNP cord-005453-4057qib7 14393 18 mismatched mismatched JJ cord-005453-4057qib7 14393 19 donor donor NN cord-005453-4057qib7 14393 20 transplantation transplantation NN cord-005453-4057qib7 14393 21 . . . cord-005453-4057qib7 14394 1 ptCy ptcy EX cord-005453-4057qib7 14394 2 has have VBZ cord-005453-4057qib7 14394 3 been be VBN cord-005453-4057qib7 14394 4 adopted adopt VBN cord-005453-4057qib7 14394 5 in in IN cord-005453-4057qib7 14394 6 many many JJ cord-005453-4057qib7 14394 7 centers center NNS cord-005453-4057qib7 14394 8 as as IN cord-005453-4057qib7 14394 9 de de FW cord-005453-4057qib7 14394 10 facto facto FW cord-005453-4057qib7 14394 11 standard standard NN cord-005453-4057qib7 14394 12 for for IN cord-005453-4057qib7 14394 13 HCT HCT NNP cord-005453-4057qib7 14394 14 from from IN cord-005453-4057qib7 14394 15 haploidentical haploidentical JJ cord-005453-4057qib7 14394 16 donors donor NNS cord-005453-4057qib7 14394 17 ( ( -LRB- cord-005453-4057qib7 14394 18 haplo haplo NNP cord-005453-4057qib7 14394 19 HCT HCT NNP cord-005453-4057qib7 14394 20 ) ) -RRB- cord-005453-4057qib7 14394 21 . . . cord-005453-4057qib7 14395 1 It -PRON- PRP cord-005453-4057qib7 14395 2 's be VBZ cord-005453-4057qib7 14395 3 use use NN cord-005453-4057qib7 14395 4 in in IN cord-005453-4057qib7 14395 5 mismatched mismatched JJ cord-005453-4057qib7 14395 6 unrelated unrelated JJ cord-005453-4057qib7 14395 7 donor donor NN cord-005453-4057qib7 14395 8 transplant transplant NN cord-005453-4057qib7 14395 9 ( ( -LRB- cord-005453-4057qib7 14395 10 MMUD MMUD NNP cord-005453-4057qib7 14395 11 HCT HCT NNP cord-005453-4057qib7 14395 12 ) ) -RRB- cord-005453-4057qib7 14395 13 is be VBZ cord-005453-4057qib7 14395 14 less less RBR cord-005453-4057qib7 14395 15 well well RB cord-005453-4057qib7 14395 16 established establish VBN cord-005453-4057qib7 14395 17 . . . cord-005453-4057qib7 14396 1 Methods method NNS cord-005453-4057qib7 14396 2 : : : cord-005453-4057qib7 14397 1 We -PRON- PRP cord-005453-4057qib7 14397 2 analyzed analyze VBD cord-005453-4057qib7 14397 3 retrospectively retrospectively RB cord-005453-4057qib7 14397 4 outcomes outcome NNS cord-005453-4057qib7 14397 5 of of IN cord-005453-4057qib7 14397 6 contemporary contemporary JJ cord-005453-4057qib7 14397 7 cohorts cohort NNS cord-005453-4057qib7 14397 8 of of IN cord-005453-4057qib7 14397 9 patients patient NNS cord-005453-4057qib7 14397 10 who who WP cord-005453-4057qib7 14397 11 underwent undergo VBD cord-005453-4057qib7 14397 12 haplo haplo NN cord-005453-4057qib7 14397 13 HCT HCT NNP cord-005453-4057qib7 14397 14 or or CC cord-005453-4057qib7 14397 15 MMUD MMUD NNP cord-005453-4057qib7 14397 16 HCT HCT NNP cord-005453-4057qib7 14397 17 using use VBG cord-005453-4057qib7 14397 18 ptCy ptcy RB cord-005453-4057qib7 14397 19 + + CC cord-005453-4057qib7 14397 20 cyclosporine cyclosporine NN cord-005453-4057qib7 14397 21 ( ( -LRB- cord-005453-4057qib7 14397 22 CSA CSA NNP cord-005453-4057qib7 14397 23 ) ) -RRB- cord-005453-4057qib7 14397 24 and and CC cord-005453-4057qib7 14397 25 mycophenolate mycophenolate NNP cord-005453-4057qib7 14397 26 mofetil mofetil NNP cord-005453-4057qib7 14397 27 ( ( -LRB- cord-005453-4057qib7 14397 28 MMF MMF NNP cord-005453-4057qib7 14397 29 ) ) -RRB- cord-005453-4057qib7 14397 30 at at IN cord-005453-4057qib7 14397 31 our -PRON- PRP$ cord-005453-4057qib7 14397 32 center center NN cord-005453-4057qib7 14397 33 . . . cord-005453-4057qib7 14398 1 We -PRON- PRP cord-005453-4057qib7 14398 2 compared compare VBD cord-005453-4057qib7 14398 3 these these DT cord-005453-4057qib7 14398 4 outcomes outcome NNS cord-005453-4057qib7 14398 5 with with IN cord-005453-4057qib7 14398 6 outcomes outcome NNS cord-005453-4057qib7 14398 7 of of IN cord-005453-4057qib7 14398 8 cohorts cohort NNS cord-005453-4057qib7 14398 9 of of IN cord-005453-4057qib7 14398 10 patients patient NNS cord-005453-4057qib7 14398 11 who who WP cord-005453-4057qib7 14398 12 underwent undergo VBD cord-005453-4057qib7 14398 13 HCT HCT NNP cord-005453-4057qib7 14398 14 from from IN cord-005453-4057qib7 14398 15 matched match VBN cord-005453-4057qib7 14398 16 unrelated unrelated JJ cord-005453-4057qib7 14398 17 donors donor NNS cord-005453-4057qib7 14398 18 ( ( -LRB- cord-005453-4057qib7 14398 19 MUD mud NN cord-005453-4057qib7 14398 20 ) ) -RRB- cord-005453-4057qib7 14398 21 using use VBG cord-005453-4057qib7 14398 22 ATG ATG NNP cord-005453-4057qib7 14398 23 based base VBN cord-005453-4057qib7 14398 24 GvHD GvHD NNP cord-005453-4057qib7 14398 25 prophylaxis prophylaxis NN cord-005453-4057qib7 14398 26 or or CC cord-005453-4057qib7 14398 27 matched match VBN cord-005453-4057qib7 14398 28 sibling sibling NN cord-005453-4057qib7 14398 29 donor donor NN cord-005453-4057qib7 14398 30 ( ( -LRB- cord-005453-4057qib7 14398 31 MSD MSD NNP cord-005453-4057qib7 14398 32 ) ) -RRB- cord-005453-4057qib7 14398 33 with with IN cord-005453-4057qib7 14398 34 CSA CSA NNP cord-005453-4057qib7 14398 35 and and CC cord-005453-4057qib7 14398 36 MMF MMF NNP cord-005453-4057qib7 14398 37 . . . cord-005453-4057qib7 14399 1 Patients patient NNS cord-005453-4057qib7 14399 2 and and CC cord-005453-4057qib7 14399 3 donors donor NNS cord-005453-4057qib7 14399 4 were be VBD cord-005453-4057qib7 14399 5 considered consider VBN cord-005453-4057qib7 14399 6 matched match VBN cord-005453-4057qib7 14399 7 if if IN cord-005453-4057qib7 14399 8 they -PRON- PRP cord-005453-4057qib7 14399 9 Background background VBP cord-005453-4057qib7 14400 1 : : : cord-005453-4057qib7 14400 2 HLA HLA NNP cord-005453-4057qib7 14400 3 - - HYPH cord-005453-4057qib7 14400 4 alloantibodies alloantibody NNS cord-005453-4057qib7 14400 5 are be VBP cord-005453-4057qib7 14400 6 a a DT cord-005453-4057qib7 14400 7 major major JJ cord-005453-4057qib7 14400 8 risk risk NN cord-005453-4057qib7 14400 9 factor factor NN cord-005453-4057qib7 14400 10 for for IN cord-005453-4057qib7 14400 11 engraftment engraftment NN cord-005453-4057qib7 14400 12 failure failure NN cord-005453-4057qib7 14400 13 in in IN cord-005453-4057qib7 14400 14 allogeneic allogeneic JJ cord-005453-4057qib7 14400 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 14400 16 stem stem NN cord-005453-4057qib7 14400 17 cell cell NN cord-005453-4057qib7 14400 18 transplantation transplantation NN cord-005453-4057qib7 14400 19 ( ( -LRB- cord-005453-4057qib7 14400 20 HSCT HSCT NNP cord-005453-4057qib7 14400 21 ) ) -RRB- cord-005453-4057qib7 14400 22 . . . cord-005453-4057qib7 14401 1 Particularly particularly RB cord-005453-4057qib7 14401 2 , , , cord-005453-4057qib7 14401 3 complement complement VBP cord-005453-4057qib7 14401 4 fixing fixing NN cord-005453-4057qib7 14401 5 , , , cord-005453-4057qib7 14401 6 donor donor NN cord-005453-4057qib7 14401 7 specific specific JJ cord-005453-4057qib7 14401 8 antibodies antibody NNS cord-005453-4057qib7 14401 9 were be VBD cord-005453-4057qib7 14401 10 shown show VBN cord-005453-4057qib7 14401 11 to to TO cord-005453-4057qib7 14401 12 be be VB cord-005453-4057qib7 14401 13 associated associate VBN cord-005453-4057qib7 14401 14 with with IN cord-005453-4057qib7 14401 15 early early JJ cord-005453-4057qib7 14401 16 engraftment engraftment NN cord-005453-4057qib7 14401 17 failure failure NN cord-005453-4057qib7 14401 18 . . . cord-005453-4057qib7 14402 1 Prospective prospective JJ cord-005453-4057qib7 14402 2 antibody antibody NN cord-005453-4057qib7 14402 3 - - HYPH cord-005453-4057qib7 14402 4 screening screening NN cord-005453-4057qib7 14402 5 , , , cord-005453-4057qib7 14402 6 although although IN cord-005453-4057qib7 14402 7 not not RB cord-005453-4057qib7 14402 8 currently currently RB cord-005453-4057qib7 14402 9 required require VBN cord-005453-4057qib7 14402 10 for for IN cord-005453-4057qib7 14402 11 donor donor NN cord-005453-4057qib7 14402 12 search search NN cord-005453-4057qib7 14402 13 , , , cord-005453-4057qib7 14402 14 could could MD cord-005453-4057qib7 14402 15 permit permit VB cord-005453-4057qib7 14402 16 early early JJ cord-005453-4057qib7 14402 17 identification identification NN cord-005453-4057qib7 14402 18 of of IN cord-005453-4057qib7 14402 19 high high JJ cord-005453-4057qib7 14402 20 risk risk NN cord-005453-4057qib7 14402 21 patients patient NNS cord-005453-4057qib7 14402 22 for for IN cord-005453-4057qib7 14402 23 positive positive JJ cord-005453-4057qib7 14402 24 crossmatch crossmatch NN cord-005453-4057qib7 14402 25 . . . cord-005453-4057qib7 14403 1 Aim aim VB cord-005453-4057qib7 14403 2 of of IN cord-005453-4057qib7 14403 3 this this DT cord-005453-4057qib7 14403 4 study study NN cord-005453-4057qib7 14403 5 is be VBZ cord-005453-4057qib7 14403 6 to to TO cord-005453-4057qib7 14403 7 set set VB cord-005453-4057qib7 14403 8 the the DT cord-005453-4057qib7 14403 9 basis basis NN cord-005453-4057qib7 14403 10 for for IN cord-005453-4057qib7 14403 11 future future JJ cord-005453-4057qib7 14403 12 applicability applicability NN cord-005453-4057qib7 14403 13 of of IN cord-005453-4057qib7 14403 14 antibody antibody NN cord-005453-4057qib7 14403 15 - - HYPH cord-005453-4057qib7 14403 16 screening screening NN cord-005453-4057qib7 14403 17 - - HYPH cord-005453-4057qib7 14403 18 based base VBN cord-005453-4057qib7 14403 19 definition definition NN cord-005453-4057qib7 14403 20 of of IN cord-005453-4057qib7 14403 21 acceptable acceptable JJ cord-005453-4057qib7 14403 22 mismatches mismatch NNS cord-005453-4057qib7 14403 23 in in IN cord-005453-4057qib7 14403 24 donor donor NN cord-005453-4057qib7 14403 25 selection selection NN cord-005453-4057qib7 14403 26 , , , cord-005453-4057qib7 14403 27 by by IN cord-005453-4057qib7 14403 28 creating create VBG cord-005453-4057qib7 14403 29 a a DT cord-005453-4057qib7 14403 30 large large JJ cord-005453-4057qib7 14403 31 prospective prospective JJ cord-005453-4057qib7 14403 32 antibody antibody NN cord-005453-4057qib7 14403 33 - - HYPH cord-005453-4057qib7 14403 34 screening screening NN cord-005453-4057qib7 14403 35 database database NN cord-005453-4057qib7 14403 36 of of IN cord-005453-4057qib7 14403 37 patients patient NNS cord-005453-4057qib7 14403 38 due due JJ cord-005453-4057qib7 14403 39 to to TO cord-005453-4057qib7 14403 40 receive receive VB cord-005453-4057qib7 14403 41 an an DT cord-005453-4057qib7 14403 42 HLA HLA NNP cord-005453-4057qib7 14403 43 - - HYPH cord-005453-4057qib7 14403 44 mismatched mismatch VBN cord-005453-4057qib7 14403 45 allogeneic allogeneic IN cord-005453-4057qib7 14403 46 HSCT HSCT NNP cord-005453-4057qib7 14403 47 . . . cord-005453-4057qib7 14404 1 Methods method NNS cord-005453-4057qib7 14404 2 : : : cord-005453-4057qib7 14404 3 Patients patient NNS cord-005453-4057qib7 14404 4 ( ( -LRB- cord-005453-4057qib7 14404 5 n=2106 n=2106 CD cord-005453-4057qib7 14404 6 ) ) -RRB- cord-005453-4057qib7 14404 7 diagnosed diagnose VBN cord-005453-4057qib7 14404 8 with with IN cord-005453-4057qib7 14404 9 MDS MDS NNP cord-005453-4057qib7 14404 10 / / SYM cord-005453-4057qib7 14404 11 MPS MPS NNP cord-005453-4057qib7 14404 12 , , , cord-005453-4057qib7 14404 13 NHL NHL NNP cord-005453-4057qib7 14404 14 , , , cord-005453-4057qib7 14404 15 MM MM NNP cord-005453-4057qib7 14404 16 , , , cord-005453-4057qib7 14404 17 CLL CLL NNP cord-005453-4057qib7 14404 18 , , , cord-005453-4057qib7 14404 19 CML CML NNP cord-005453-4057qib7 14404 20 , , , cord-005453-4057qib7 14404 21 anaemia anaemia NN cord-005453-4057qib7 14404 22 ( ( -LRB- cord-005453-4057qib7 14404 23 aplastic aplastic JJ cord-005453-4057qib7 14404 24 anemia anemia NN cord-005453-4057qib7 14404 25 , , , cord-005453-4057qib7 14404 26 hemoglobinopathies hemoglobinopathy NNS cord-005453-4057qib7 14404 27 , , , cord-005453-4057qib7 14404 28 PNH PNH NNP cord-005453-4057qib7 14404 29 ) ) -RRB- cord-005453-4057qib7 14404 30 and and CC cord-005453-4057qib7 14404 31 HL HL NNP cord-005453-4057qib7 14404 32 were be VBD cord-005453-4057qib7 14404 33 prospectively prospectively RB cord-005453-4057qib7 14404 34 screened screen VBN cord-005453-4057qib7 14404 35 for for IN cord-005453-4057qib7 14404 36 HLA HLA NNP cord-005453-4057qib7 14404 37 - - HYPH cord-005453-4057qib7 14404 38 antibodies antibody NNS cord-005453-4057qib7 14404 39 whenever whenever WRB cord-005453-4057qib7 14404 40 initial initial JJ cord-005453-4057qib7 14404 41 donor donor NN cord-005453-4057qib7 14404 42 search search NN cord-005453-4057qib7 14404 43 indicated indicate VBD cord-005453-4057qib7 14404 44 that that IN cord-005453-4057qib7 14404 45 no no DT cord-005453-4057qib7 14404 46 completely completely RB cord-005453-4057qib7 14404 47 matched match VBN cord-005453-4057qib7 14404 48 donor donor NN cord-005453-4057qib7 14404 49 would would MD cord-005453-4057qib7 14404 50 be be VB cord-005453-4057qib7 14404 51 available available JJ cord-005453-4057qib7 14404 52 . . . cord-005453-4057qib7 14405 1 Screening screening NN cord-005453-4057qib7 14405 2 was be VBD cord-005453-4057qib7 14405 3 performed perform VBN cord-005453-4057qib7 14405 4 with with IN cord-005453-4057qib7 14405 5 an an DT cord-005453-4057qib7 14405 6 ELISA ELISA NNP cord-005453-4057qib7 14405 7 class class NN cord-005453-4057qib7 14405 8 I i NN cord-005453-4057qib7 14405 9 + + CC cord-005453-4057qib7 14405 10 II II NNP cord-005453-4057qib7 14405 11 screening screening NN cord-005453-4057qib7 14405 12 assay assay NN cord-005453-4057qib7 14405 13 . . . cord-005453-4057qib7 14406 1 All all DT cord-005453-4057qib7 14406 2 positive positive JJ cord-005453-4057qib7 14406 3 screening screening NN cord-005453-4057qib7 14406 4 cases case NNS cord-005453-4057qib7 14406 5 were be VBD cord-005453-4057qib7 14406 6 tested test VBN cord-005453-4057qib7 14406 7 for for IN cord-005453-4057qib7 14406 8 antigen antigen NN cord-005453-4057qib7 14406 9 - - HYPH cord-005453-4057qib7 14406 10 specific specific JJ cord-005453-4057qib7 14406 11 antibody antibody NN cord-005453-4057qib7 14406 12 identification identification NN cord-005453-4057qib7 14406 13 with with IN cord-005453-4057qib7 14406 14 Luminex Luminex NNP cord-005453-4057qib7 14406 15 SAB SAB NNP cord-005453-4057qib7 14406 16 , , , cord-005453-4057qib7 14406 17 and and CC cord-005453-4057qib7 14406 18 acceptable acceptable JJ cord-005453-4057qib7 14406 19 mismatches mismatch NNS cord-005453-4057qib7 14406 20 were be VBD cord-005453-4057qib7 14406 21 defined define VBN cord-005453-4057qib7 14406 22 . . . cord-005453-4057qib7 14407 1 The the DT cord-005453-4057qib7 14407 2 results result NNS cord-005453-4057qib7 14407 3 were be VBD cord-005453-4057qib7 14407 4 subsequently subsequently RB cord-005453-4057qib7 14407 5 considered consider VBN cord-005453-4057qib7 14407 6 in in IN cord-005453-4057qib7 14407 7 donor donor NN cord-005453-4057qib7 14407 8 search search NN cord-005453-4057qib7 14407 9 and and CC cord-005453-4057qib7 14407 10 selection selection NN cord-005453-4057qib7 14407 11 . . . cord-005453-4057qib7 14408 1 We -PRON- PRP cord-005453-4057qib7 14408 2 now now RB cord-005453-4057qib7 14408 3 report report VBP cord-005453-4057qib7 14408 4 the the DT cord-005453-4057qib7 14408 5 frequencies frequency NNS cord-005453-4057qib7 14408 6 of of IN cord-005453-4057qib7 14408 7 alloimmunization alloimmunization NN cord-005453-4057qib7 14408 8 observed observe VBN cord-005453-4057qib7 14408 9 in in IN cord-005453-4057qib7 14408 10 these these DT cord-005453-4057qib7 14408 11 patients patient NNS cord-005453-4057qib7 14408 12 . . . cord-005453-4057qib7 14409 1 Results result NNS cord-005453-4057qib7 14409 2 : : : cord-005453-4057qib7 14410 1 The the DT cord-005453-4057qib7 14410 2 highest high JJS cord-005453-4057qib7 14410 3 rate rate NN cord-005453-4057qib7 14410 4 of of IN cord-005453-4057qib7 14410 5 alloimmunization alloimmunization NN cord-005453-4057qib7 14410 6 was be VBD cord-005453-4057qib7 14410 7 observed observe VBN cord-005453-4057qib7 14410 8 in in IN cord-005453-4057qib7 14410 9 patients patient NNS cord-005453-4057qib7 14410 10 from from IN cord-005453-4057qib7 14410 11 the the DT cord-005453-4057qib7 14410 12 anaemia anaemia NN cord-005453-4057qib7 14410 13 disease disease NN cord-005453-4057qib7 14410 14 group group NN cord-005453-4057qib7 14410 15 ( ( -LRB- cord-005453-4057qib7 14410 16 overall overall JJ cord-005453-4057qib7 14410 17 40.5 40.5 CD cord-005453-4057qib7 14410 18 % % NN cord-005453-4057qib7 14410 19 ) ) -RRB- cord-005453-4057qib7 14410 20 followed follow VBN cord-005453-4057qib7 14410 21 by by IN cord-005453-4057qib7 14410 22 those those DT cord-005453-4057qib7 14410 23 from from IN cord-005453-4057qib7 14410 24 the the DT cord-005453-4057qib7 14410 25 MDS MDS NNP cord-005453-4057qib7 14410 26 / / SYM cord-005453-4057qib7 14410 27 MPN MPN NNP cord-005453-4057qib7 14410 28 group group NN cord-005453-4057qib7 14410 29 ( ( -LRB- cord-005453-4057qib7 14410 30 overall overall JJ cord-005453-4057qib7 14410 31 24.8 24.8 CD cord-005453-4057qib7 14410 32 % % NN cord-005453-4057qib7 14410 33 ) ) -RRB- cord-005453-4057qib7 14410 34 . . . cord-005453-4057qib7 14411 1 The the DT cord-005453-4057qib7 14411 2 lowest low JJS cord-005453-4057qib7 14411 3 immunization immunization NN cord-005453-4057qib7 14411 4 rates rate NNS cord-005453-4057qib7 14411 5 were be VBD cord-005453-4057qib7 14411 6 observed observe VBN cord-005453-4057qib7 14411 7 in in IN cord-005453-4057qib7 14411 8 CLL CLL NNP cord-005453-4057qib7 14411 9 ( ( -LRB- cord-005453-4057qib7 14411 10 overall overall JJ cord-005453-4057qib7 14411 11 6.9 6.9 CD cord-005453-4057qib7 14411 12 % % NN cord-005453-4057qib7 14411 13 ) ) -RRB- cord-005453-4057qib7 14411 14 and and CC cord-005453-4057qib7 14411 15 HL HL NNP cord-005453-4057qib7 14411 16 ( ( -LRB- cord-005453-4057qib7 14411 17 7.0 7.0 CD cord-005453-4057qib7 14411 18 % % NN cord-005453-4057qib7 14411 19 ) ) -RRB- cord-005453-4057qib7 14411 20 patients patient NNS cord-005453-4057qib7 14411 21 . . . cord-005453-4057qib7 14412 1 Alloimmunization alloimmunization NN cord-005453-4057qib7 14412 2 rates rate NNS cord-005453-4057qib7 14412 3 for for IN cord-005453-4057qib7 14412 4 HLA HLA NNP cord-005453-4057qib7 14412 5 - - HYPH cord-005453-4057qib7 14412 6 class class NN cord-005453-4057qib7 14412 7 I i NN cord-005453-4057qib7 14412 8 antigens antigen VBZ cord-005453-4057qib7 14412 9 ( ( -LRB- cord-005453-4057qib7 14412 10 p p NN cord-005453-4057qib7 14412 11 < < XX cord-005453-4057qib7 14412 12 0.001 0.001 CD cord-005453-4057qib7 14412 13 ) ) -RRB- cord-005453-4057qib7 14412 14 were be VBD cord-005453-4057qib7 14412 15 significantly significantly RB cord-005453-4057qib7 14412 16 higher high JJR cord-005453-4057qib7 14412 17 compared compare VBN cord-005453-4057qib7 14412 18 to to IN cord-005453-4057qib7 14412 19 HLA HLA NNP cord-005453-4057qib7 14412 20 - - HYPH cord-005453-4057qib7 14412 21 class class NN cord-005453-4057qib7 14412 22 II II NNP cord-005453-4057qib7 14412 23 antigens antigen NNS cord-005453-4057qib7 14412 24 . . . cord-005453-4057qib7 14413 1 Overall overall JJ cord-005453-4057qib7 14413 2 HLA HLA NNP cord-005453-4057qib7 14413 3 - - HYPH cord-005453-4057qib7 14413 4 class class NN cord-005453-4057qib7 14413 5 I i NN cord-005453-4057qib7 14413 6 immunization immunization NN cord-005453-4057qib7 14413 7 rates rate NNS cord-005453-4057qib7 14413 8 ranged range VBD cord-005453-4057qib7 14413 9 from from IN cord-005453-4057qib7 14413 10 2.3 2.3 CD cord-005453-4057qib7 14413 11 % % NN cord-005453-4057qib7 14413 12 to to IN cord-005453-4057qib7 14413 13 33.3 33.3 CD cord-005453-4057qib7 14413 14 % % NN cord-005453-4057qib7 14413 15 . . . cord-005453-4057qib7 14414 1 HLA HLA NNP cord-005453-4057qib7 14414 2 - - HYPH cord-005453-4057qib7 14414 3 class class NN cord-005453-4057qib7 14414 4 II II NNP cord-005453-4057qib7 14414 5 immunization immunization NN cord-005453-4057qib7 14414 6 rates rate NNS cord-005453-4057qib7 14414 7 ranged range VBD cord-005453-4057qib7 14414 8 from from IN cord-005453-4057qib7 14414 9 4.7 4.7 CD cord-005453-4057qib7 14414 10 % % NN cord-005453-4057qib7 14414 11 to to IN cord-005453-4057qib7 14414 12 19.8 19.8 CD cord-005453-4057qib7 14414 13 % % NN cord-005453-4057qib7 14414 14 ( ( -LRB- cord-005453-4057qib7 14414 15 table table NN cord-005453-4057qib7 14414 16 1 1 CD cord-005453-4057qib7 14414 17 ) ) -RRB- cord-005453-4057qib7 14414 18 . . . cord-005453-4057qib7 14415 1 Conclusions conclusion NNS cord-005453-4057qib7 14415 2 : : : cord-005453-4057qib7 14416 1 Our -PRON- PRP$ cord-005453-4057qib7 14416 2 findings finding NNS cord-005453-4057qib7 14416 3 suggest suggest VBP cord-005453-4057qib7 14416 4 that that IN cord-005453-4057qib7 14416 5 patients patient NNS cord-005453-4057qib7 14416 6 with with IN cord-005453-4057qib7 14416 7 high high JJ cord-005453-4057qib7 14416 8 transfusion transfusion NN cord-005453-4057qib7 14416 9 burden burden NN cord-005453-4057qib7 14416 10 like like IN cord-005453-4057qib7 14416 11 anaemia anaemia NN cord-005453-4057qib7 14416 12 and and CC cord-005453-4057qib7 14416 13 MDS MDS NNP cord-005453-4057qib7 14416 14 / / SYM cord-005453-4057qib7 14416 15 MPN MPN NNP cord-005453-4057qib7 14416 16 patients patient NNS cord-005453-4057qib7 14416 17 have have VBP cord-005453-4057qib7 14416 18 the the DT cord-005453-4057qib7 14416 19 highest high JJS cord-005453-4057qib7 14416 20 risk risk NN cord-005453-4057qib7 14416 21 of of IN cord-005453-4057qib7 14416 22 HLA HLA NNP cord-005453-4057qib7 14416 23 - - HYPH cord-005453-4057qib7 14416 24 alloimmunization alloimmunization NN cord-005453-4057qib7 14416 25 with with IN cord-005453-4057qib7 14416 26 40.5 40.5 CD cord-005453-4057qib7 14416 27 % % NN cord-005453-4057qib7 14416 28 and and CC cord-005453-4057qib7 14416 29 24.8 24.8 CD cord-005453-4057qib7 14416 30 % % NN cord-005453-4057qib7 14416 31 anti anti JJ cord-005453-4057qib7 14416 32 - - JJ cord-005453-4057qib7 14416 33 HLA hla JJ cord-005453-4057qib7 14416 34 prevalence prevalence NN cord-005453-4057qib7 14416 35 rates rate NNS cord-005453-4057qib7 14416 36 , , , cord-005453-4057qib7 14416 37 respectively respectively RB cord-005453-4057qib7 14416 38 . . . cord-005453-4057qib7 14417 1 Analysis analysis NN cord-005453-4057qib7 14417 2 of of IN cord-005453-4057qib7 14417 3 follow follow VB cord-005453-4057qib7 14417 4 - - HYPH cord-005453-4057qib7 14417 5 up up NN cord-005453-4057qib7 14417 6 data datum NNS cord-005453-4057qib7 14417 7 , , , cord-005453-4057qib7 14417 8 will will MD cord-005453-4057qib7 14417 9 enable enable VB cord-005453-4057qib7 14417 10 us -PRON- PRP cord-005453-4057qib7 14417 11 to to TO cord-005453-4057qib7 14417 12 confirm confirm VB cord-005453-4057qib7 14417 13 whether whether IN cord-005453-4057qib7 14417 14 prospective prospective JJ cord-005453-4057qib7 14417 15 definition definition NN cord-005453-4057qib7 14417 16 and and CC cord-005453-4057qib7 14417 17 consideration consideration NN cord-005453-4057qib7 14417 18 of of IN cord-005453-4057qib7 14417 19 acceptable acceptable JJ cord-005453-4057qib7 14417 20 mismatches mismatch NNS cord-005453-4057qib7 14417 21 in in IN cord-005453-4057qib7 14417 22 donor donor NN cord-005453-4057qib7 14417 23 selection selection NN cord-005453-4057qib7 14417 24 may may MD cord-005453-4057qib7 14417 25 lead lead VB cord-005453-4057qib7 14417 26 to to IN cord-005453-4057qib7 14417 27 similar similar JJ cord-005453-4057qib7 14417 28 engraftment engraftment NN cord-005453-4057qib7 14417 29 failure failure NN cord-005453-4057qib7 14417 30 rates rate NNS cord-005453-4057qib7 14417 31 between between IN cord-005453-4057qib7 14417 32 immunized immunized JJ cord-005453-4057qib7 14417 33 and and CC cord-005453-4057qib7 14417 34 non non JJ cord-005453-4057qib7 14417 35 - - JJ cord-005453-4057qib7 14417 36 immunized immunize VBN cord-005453-4057qib7 14417 37 patients patient NNS cord-005453-4057qib7 14417 38 undergoing undergo VBG cord-005453-4057qib7 14417 39 HLAmismatched hlamismatche VBN cord-005453-4057qib7 14417 40 HSCT HSCT NNP cord-005453-4057qib7 14417 41 . . . cord-005453-4057qib7 14418 1 Background background NN cord-005453-4057qib7 14418 2 : : : cord-005453-4057qib7 14418 3 Mothers mother NNS cord-005453-4057qib7 14418 4 displaying display VBG cord-005453-4057qib7 14418 5 a a DT cord-005453-4057qib7 14418 6 persistent persistent JJ cord-005453-4057qib7 14418 7 fetal fetal JJ cord-005453-4057qib7 14418 8 microchimerism microchimerism NN cord-005453-4057qib7 14418 9 ( ( -LRB- cord-005453-4057qib7 14418 10 FM FM NNP cord-005453-4057qib7 14418 11 ) ) -RRB- cord-005453-4057qib7 14418 12 proved prove VBD cord-005453-4057qib7 14418 13 to to TO cord-005453-4057qib7 14418 14 be be VB cord-005453-4057qib7 14418 15 the the DT cord-005453-4057qib7 14418 16 most most RBS cord-005453-4057qib7 14418 17 suitable suitable JJ cord-005453-4057qib7 14418 18 donor donor NN cord-005453-4057qib7 14418 19 in in IN cord-005453-4057qib7 14418 20 T T NNP cord-005453-4057qib7 14418 21 cell cell NN cord-005453-4057qib7 14418 22 - - HYPH cord-005453-4057qib7 14418 23 depleted deplete VBN cord-005453-4057qib7 14418 24 haploidentical haploidentical JJ cord-005453-4057qib7 14418 25 stem stem NN cord-005453-4057qib7 14418 26 cell cell NN cord-005453-4057qib7 14418 27 transplantation transplantation NN cord-005453-4057qib7 14418 28 ( ( -LRB- cord-005453-4057qib7 14418 29 hHSCT hHSCT NNP cord-005453-4057qib7 14418 30 ) ) -RRB- cord-005453-4057qib7 14418 31 in in IN cord-005453-4057qib7 14418 32 children child NNS cord-005453-4057qib7 14418 33 . . . cord-005453-4057qib7 14419 1 We -PRON- PRP cord-005453-4057qib7 14419 2 presumed presume VBD cord-005453-4057qib7 14419 3 that that IN cord-005453-4057qib7 14419 4 fetal fetal JJ cord-005453-4057qib7 14419 5 cells cell NNS cord-005453-4057qib7 14419 6 leave leave VBP cord-005453-4057qib7 14419 7 an an DT cord-005453-4057qib7 14419 8 imprint imprint NN cord-005453-4057qib7 14419 9 in in IN cord-005453-4057qib7 14419 10 the the DT cord-005453-4057qib7 14419 11 mothers mother NNS cord-005453-4057qib7 14419 12 ' ' POS cord-005453-4057qib7 14419 13 immune immune JJ cord-005453-4057qib7 14419 14 system system NN cord-005453-4057qib7 14419 15 which which WDT cord-005453-4057qib7 14419 16 positively positively RB cord-005453-4057qib7 14419 17 affects affect VBZ cord-005453-4057qib7 14419 18 recognition recognition NN cord-005453-4057qib7 14419 19 and and CC cord-005453-4057qib7 14419 20 elimination elimination NN cord-005453-4057qib7 14419 21 of of IN cord-005453-4057qib7 14419 22 malignant malignant JJ cord-005453-4057qib7 14419 23 cells cell NNS cord-005453-4057qib7 14419 24 in in IN cord-005453-4057qib7 14419 25 the the DT cord-005453-4057qib7 14419 26 child child NN cord-005453-4057qib7 14419 27 by by IN cord-005453-4057qib7 14419 28 maternal maternal JJ cord-005453-4057qib7 14419 29 effector effector NN cord-005453-4057qib7 14419 30 cells cell NNS cord-005453-4057qib7 14419 31 . . . cord-005453-4057qib7 14420 1 Distinct distinct JJ cord-005453-4057qib7 14420 2 killer killer NN cord-005453-4057qib7 14420 3 cell cell NN cord-005453-4057qib7 14420 4 immunoglobulin immunoglobulin NN cord-005453-4057qib7 14420 5 - - HYPH cord-005453-4057qib7 14420 6 like like JJ cord-005453-4057qib7 14420 7 receptors receptor NNS cord-005453-4057qib7 14421 1 ( ( -LRB- cord-005453-4057qib7 14421 2 KIR)/HLA KIR)/HLA NNP cord-005453-4057qib7 14421 3 constellations constellation NNS cord-005453-4057qib7 14421 4 are be VBP cord-005453-4057qib7 14421 5 not not RB cord-005453-4057qib7 14421 6 only only RB cord-005453-4057qib7 14421 7 associated associate VBN cord-005453-4057qib7 14421 8 with with IN cord-005453-4057qib7 14421 9 reduced reduce VBN cord-005453-4057qib7 14421 10 relapse relapse NN cord-005453-4057qib7 14421 11 rates rate NNS cord-005453-4057qib7 14421 12 after after IN cord-005453-4057qib7 14421 13 HSCT HSCT NNP cord-005453-4057qib7 14421 14 in in IN cord-005453-4057qib7 14421 15 children child NNS cord-005453-4057qib7 14421 16 , , , cord-005453-4057qib7 14421 17 but but CC cord-005453-4057qib7 14421 18 also also RB cord-005453-4057qib7 14421 19 supposedly supposedly RB cord-005453-4057qib7 14421 20 influence influence VB cord-005453-4057qib7 14421 21 the the DT cord-005453-4057qib7 14421 22 establishment establishment NN cord-005453-4057qib7 14421 23 of of IN cord-005453-4057qib7 14421 24 an an DT cord-005453-4057qib7 14421 25 FM FM NNP cord-005453-4057qib7 14421 26 . . . cord-005453-4057qib7 14422 1 Methods method NNS cord-005453-4057qib7 14422 2 : : : cord-005453-4057qib7 14423 1 After after IN cord-005453-4057qib7 14423 2 approval approval NN cord-005453-4057qib7 14423 3 by by IN cord-005453-4057qib7 14423 4 the the DT cord-005453-4057qib7 14423 5 local local JJ cord-005453-4057qib7 14423 6 IRB IRB NNP cord-005453-4057qib7 14423 7 and and CC cord-005453-4057qib7 14423 8 obtaining obtain VBG cord-005453-4057qib7 14423 9 informed informed JJ cord-005453-4057qib7 14423 10 consent consent NN cord-005453-4057qib7 14423 11 , , , cord-005453-4057qib7 14423 12 we -PRON- PRP cord-005453-4057qib7 14423 13 initiated initiate VBD cord-005453-4057qib7 14423 14 a a DT cord-005453-4057qib7 14423 15 protocol protocol NN cord-005453-4057qib7 14423 16 to to TO cord-005453-4057qib7 14423 17 elucidate elucidate VB cord-005453-4057qib7 14423 18 the the DT cord-005453-4057qib7 14423 19 factors factor NNS cord-005453-4057qib7 14423 20 that that WDT cord-005453-4057qib7 14423 21 influence influence VBP cord-005453-4057qib7 14423 22 the the DT cord-005453-4057qib7 14423 23 establishment establishment NN cord-005453-4057qib7 14423 24 , , , cord-005453-4057qib7 14423 25 persistence persistence NN cord-005453-4057qib7 14423 26 and and CC cord-005453-4057qib7 14423 27 effect effect NN cord-005453-4057qib7 14423 28 of of IN cord-005453-4057qib7 14423 29 FM FM NNP cord-005453-4057qib7 14423 30 . . . cord-005453-4057qib7 14424 1 We -PRON- PRP cord-005453-4057qib7 14424 2 established establish VBD cord-005453-4057qib7 14424 3 a a DT cord-005453-4057qib7 14424 4 digital digital JJ cord-005453-4057qib7 14424 5 droplet droplet NN cord-005453-4057qib7 14424 6 PCR PCR NNP cord-005453-4057qib7 14424 7 ( ( -LRB- cord-005453-4057qib7 14424 8 ddPCR ddPCR NNP cord-005453-4057qib7 14424 9 ) ) -RRB- cord-005453-4057qib7 14424 10 protocol protocol NN cord-005453-4057qib7 14424 11 to to TO cord-005453-4057qib7 14424 12 determine determine VB cord-005453-4057qib7 14424 13 the the DT cord-005453-4057qib7 14424 14 fetal fetal JJ cord-005453-4057qib7 14424 15 microchimerism microchimerism NN cord-005453-4057qib7 14424 16 . . . cord-005453-4057qib7 14425 1 For for IN cord-005453-4057qib7 14425 2 differentiation differentiation NN cord-005453-4057qib7 14425 3 between between IN cord-005453-4057qib7 14425 4 maternal maternal JJ cord-005453-4057qib7 14425 5 and and CC cord-005453-4057qib7 14425 6 fetal fetal JJ cord-005453-4057qib7 14425 7 cells cell NNS cord-005453-4057qib7 14425 8 , , , cord-005453-4057qib7 14425 9 biallelic biallelic NN cord-005453-4057qib7 14425 10 short short JJ cord-005453-4057qib7 14425 11 insertion insertion NN cord-005453-4057qib7 14425 12 / / SYM cord-005453-4057qib7 14425 13 deletion deletion NN cord-005453-4057qib7 14425 14 polymorphisms polymorphism NNS cord-005453-4057qib7 14425 15 were be VBD cord-005453-4057qib7 14425 16 used use VBN cord-005453-4057qib7 14425 17 . . . cord-005453-4057qib7 14426 1 KIR KIR NNP cord-005453-4057qib7 14426 2 and and CC cord-005453-4057qib7 14426 3 HLA HLA NNP cord-005453-4057qib7 14426 4 - - HYPH cord-005453-4057qib7 14426 5 C C NNP cord-005453-4057qib7 14426 6 genotyping genotyping NN cord-005453-4057qib7 14426 7 was be VBD cord-005453-4057qib7 14426 8 performed perform VBN cord-005453-4057qib7 14426 9 by by IN cord-005453-4057qib7 14426 10 SSP SSP NNP cord-005453-4057qib7 14426 11 - - HYPH cord-005453-4057qib7 14426 12 PCR PCR NNP cord-005453-4057qib7 14426 13 . . . cord-005453-4057qib7 14427 1 Parental parental JJ cord-005453-4057qib7 14427 2 NK NK NNP cord-005453-4057qib7 14427 3 cell cell NN cord-005453-4057qib7 14427 4 alloreactivity alloreactivity NN cord-005453-4057qib7 14427 5 against against IN cord-005453-4057qib7 14427 6 the the DT cord-005453-4057qib7 14427 7 respective respective JJ cord-005453-4057qib7 14427 8 leukemic leukemic JJ cord-005453-4057qib7 14427 9 blasts blast NNS cord-005453-4057qib7 14427 10 and and CC cord-005453-4057qib7 14427 11 KIR KIR NNP cord-005453-4057qib7 14427 12 phenotyping phenotyping NN cord-005453-4057qib7 14427 13 were be VBD cord-005453-4057qib7 14427 14 analyzed analyze VBN cord-005453-4057qib7 14427 15 by by IN cord-005453-4057qib7 14427 16 flow flow NN cord-005453-4057qib7 14427 17 cytometry cytometry NN cord-005453-4057qib7 14427 18 . . . cord-005453-4057qib7 14428 1 Results result NNS cord-005453-4057qib7 14428 2 : : : cord-005453-4057qib7 14429 1 We -PRON- PRP cord-005453-4057qib7 14429 2 analyzed analyze VBD cord-005453-4057qib7 14429 3 45 45 CD cord-005453-4057qib7 14429 4 parents parent NNS cord-005453-4057qib7 14429 5 , , , cord-005453-4057qib7 14429 6 whose whose WP$ cord-005453-4057qib7 14429 7 children child NNS cord-005453-4057qib7 14429 8 were be VBD cord-005453-4057qib7 14429 9 treated treat VBN cord-005453-4057qib7 14429 10 for for IN cord-005453-4057qib7 14429 11 hematological hematological JJ cord-005453-4057qib7 14429 12 diseases disease NNS cord-005453-4057qib7 14429 13 at at IN cord-005453-4057qib7 14429 14 the the DT cord-005453-4057qib7 14429 15 University University NNP cord-005453-4057qib7 14429 16 Medical Medical NNP cord-005453-4057qib7 14429 17 Center Center NNP cord-005453-4057qib7 14429 18 Hamburg Hamburg NNP cord-005453-4057qib7 14429 19 - - HYPH cord-005453-4057qib7 14429 20 Eppendorf Eppendorf NNP cord-005453-4057qib7 14429 21 . . . cord-005453-4057qib7 14430 1 A a DT cord-005453-4057qib7 14430 2 fetal fetal JJ cord-005453-4057qib7 14430 3 microchimerism microchimerism NN cord-005453-4057qib7 14430 4 was be VBD cord-005453-4057qib7 14430 5 detected detect VBN cord-005453-4057qib7 14430 6 in in IN cord-005453-4057qib7 14430 7 25 25 CD cord-005453-4057qib7 14430 8 % % NN cord-005453-4057qib7 14430 9 of of IN cord-005453-4057qib7 14430 10 the the DT cord-005453-4057qib7 14430 11 mothers mother NNS cord-005453-4057qib7 14430 12 . . . cord-005453-4057qib7 14431 1 The the DT cord-005453-4057qib7 14431 2 amount amount NN cord-005453-4057qib7 14431 3 of of IN cord-005453-4057qib7 14431 4 fetal fetal JJ cord-005453-4057qib7 14431 5 cells cell NNS cord-005453-4057qib7 14431 6 varies vary VBZ cord-005453-4057qib7 14431 7 between between IN cord-005453-4057qib7 14431 8 individuals individual NNS cord-005453-4057qib7 14431 9 ( ( -LRB- cord-005453-4057qib7 14431 10 8x 8x CD cord-005453-4057qib7 14431 11 10 10 CD cord-005453-4057qib7 14431 12 -6 -6 CD cord-005453-4057qib7 14431 13 -9x -9x CD cord-005453-4057qib7 14431 14 10 10 CD cord-005453-4057qib7 14431 15 -4 -4 CD cord-005453-4057qib7 14431 16 ) ) -RRB- cord-005453-4057qib7 14431 17 . . . cord-005453-4057qib7 14432 1 We -PRON- PRP cord-005453-4057qib7 14432 2 observed observe VBD cord-005453-4057qib7 14432 3 a a DT cord-005453-4057qib7 14432 4 positive positive JJ cord-005453-4057qib7 14432 5 correlation correlation NN cord-005453-4057qib7 14432 6 between between IN cord-005453-4057qib7 14432 7 a a DT cord-005453-4057qib7 14432 8 persisting persist VBG cord-005453-4057qib7 14432 9 FM FM NNP cord-005453-4057qib7 14432 10 and and CC cord-005453-4057qib7 14432 11 HLA HLA NNP cord-005453-4057qib7 14432 12 - - HYPH cord-005453-4057qib7 14432 13 C1 C1 NNP cord-005453-4057qib7 14432 14 homo homo NN cord-005453-4057qib7 14432 15 - - HYPH cord-005453-4057qib7 14432 16 and and CC cord-005453-4057qib7 14432 17 heterozygous heterozygous JJ cord-005453-4057qib7 14432 18 mothers mother NNS cord-005453-4057qib7 14432 19 along along IN cord-005453-4057qib7 14432 20 with with IN cord-005453-4057qib7 14432 21 a a DT cord-005453-4057qib7 14432 22 maternal maternal JJ cord-005453-4057qib7 14432 23 Cen Cen NNP cord-005453-4057qib7 14432 24 A A NNP cord-005453-4057qib7 14432 25 / / SYM cord-005453-4057qib7 14432 26 B B NNP cord-005453-4057qib7 14432 27 and and CC cord-005453-4057qib7 14432 28 Cen Cen NNP cord-005453-4057qib7 14432 29 B B NNP cord-005453-4057qib7 14432 30 / / SYM cord-005453-4057qib7 14432 31 B B NNP cord-005453-4057qib7 14432 32 genotype genotype NN cord-005453-4057qib7 14432 33 . . . cord-005453-4057qib7 14433 1 Additionally additionally RB cord-005453-4057qib7 14433 2 , , , cord-005453-4057qib7 14433 3 FM FM NNP cord-005453-4057qib7 14433 4 positive positive JJ cord-005453-4057qib7 14433 5 mothers mother NNS cord-005453-4057qib7 14433 6 showed show VBD cord-005453-4057qib7 14433 7 a a DT cord-005453-4057qib7 14433 8 higher high JJR cord-005453-4057qib7 14433 9 surface surface NN cord-005453-4057qib7 14433 10 expression expression NN cord-005453-4057qib7 14433 11 of of IN cord-005453-4057qib7 14433 12 the the DT cord-005453-4057qib7 14433 13 HLA HLA NNP cord-005453-4057qib7 14433 14 - - HYPH cord-005453-4057qib7 14433 15 C1 C1 NNP cord-005453-4057qib7 14433 16 respective respective JJ cord-005453-4057qib7 14433 17 receptors receptor NNS cord-005453-4057qib7 14433 18 KIR2DL2 KIR2DL2 VBZ cord-005453-4057qib7 14433 19 / / SYM cord-005453-4057qib7 14433 20 S2 s2 NN cord-005453-4057qib7 14433 21 . . . cord-005453-4057qib7 14434 1 The the DT cord-005453-4057qib7 14434 2 percentage percentage NN cord-005453-4057qib7 14434 3 of of IN cord-005453-4057qib7 14434 4 alloreactive alloreactive JJ cord-005453-4057qib7 14434 5 maternal maternal JJ cord-005453-4057qib7 14434 6 NK NK NNP cord-005453-4057qib7 14434 7 cells cell NNS cord-005453-4057qib7 14434 8 against against IN cord-005453-4057qib7 14434 9 fetal fetal JJ cord-005453-4057qib7 14434 10 cells cell NNS cord-005453-4057qib7 14434 11 was be VBD cord-005453-4057qib7 14434 12 higher high JJR cord-005453-4057qib7 14434 13 compared compare VBN cord-005453-4057qib7 14434 14 to to IN cord-005453-4057qib7 14434 15 paternal paternal JJ cord-005453-4057qib7 14434 16 NK NK NNP cord-005453-4057qib7 14434 17 cells cell NNS cord-005453-4057qib7 14434 18 ; ; : cord-005453-4057qib7 14434 19 while while IN cord-005453-4057qib7 14434 20 alloreactivity alloreactivity NN cord-005453-4057qib7 14434 21 of of IN cord-005453-4057qib7 14434 22 FM FM NNP cord-005453-4057qib7 14434 23 positive positive JJ cord-005453-4057qib7 14434 24 maternal maternal JJ cord-005453-4057qib7 14434 25 NK NK NNP cord-005453-4057qib7 14434 26 cells cell NNS cord-005453-4057qib7 14434 27 was be VBD cord-005453-4057qib7 14434 28 similar similar JJ cord-005453-4057qib7 14434 29 to to IN cord-005453-4057qib7 14434 30 NK NK NNP cord-005453-4057qib7 14434 31 cells cell NNS cord-005453-4057qib7 14434 32 from from IN cord-005453-4057qib7 14434 33 FM FM NNP cord-005453-4057qib7 14434 34 negative negative JJ cord-005453-4057qib7 14434 35 mothers mother NNS cord-005453-4057qib7 14434 36 . . . cord-005453-4057qib7 14435 1 Conclusions conclusion NNS cord-005453-4057qib7 14435 2 : : : cord-005453-4057qib7 14436 1 Persistence persistence NN cord-005453-4057qib7 14436 2 of of IN cord-005453-4057qib7 14436 3 FM FM NNP cord-005453-4057qib7 14436 4 was be VBD cord-005453-4057qib7 14436 5 more more RBR cord-005453-4057qib7 14436 6 frequent frequent JJ cord-005453-4057qib7 14436 7 in in IN cord-005453-4057qib7 14436 8 mothers mother NNS cord-005453-4057qib7 14436 9 carrying carry VBG cord-005453-4057qib7 14436 10 at at RB cord-005453-4057qib7 14436 11 least least RBS cord-005453-4057qib7 14436 12 one one CD cord-005453-4057qib7 14436 13 HLA HLA NNP cord-005453-4057qib7 14436 14 - - HYPH cord-005453-4057qib7 14436 15 C1 C1 NNP cord-005453-4057qib7 14436 16 allele allele NN cord-005453-4057qib7 14436 17 and and CC cord-005453-4057qib7 14436 18 a a DT cord-005453-4057qib7 14436 19 centromeric centromeric NN cord-005453-4057qib7 14436 20 B b NN cord-005453-4057qib7 14436 21 / / SYM cord-005453-4057qib7 14436 22 x x NN cord-005453-4057qib7 14436 23 motif motif NN cord-005453-4057qib7 14436 24 . . . cord-005453-4057qib7 14437 1 Phenotypically Phenotypically NNP cord-005453-4057qib7 14437 2 , , , cord-005453-4057qib7 14437 3 FM FM NNP cord-005453-4057qib7 14437 4 positive positive JJ cord-005453-4057qib7 14437 5 mothers mother NNS cord-005453-4057qib7 14437 6 had have VBD cord-005453-4057qib7 14437 7 higher high JJR cord-005453-4057qib7 14437 8 expression expression NN cord-005453-4057qib7 14437 9 of of IN cord-005453-4057qib7 14437 10 KIR2DL2 KIR2DL2 NNP cord-005453-4057qib7 14437 11 / / SYM cord-005453-4057qib7 14437 12 S2 s2 NN cord-005453-4057qib7 14437 13 indicating indicate VBG cord-005453-4057qib7 14437 14 a a DT cord-005453-4057qib7 14437 15 role role NN cord-005453-4057qib7 14437 16 of of IN cord-005453-4057qib7 14437 17 these these DT cord-005453-4057qib7 14437 18 receptors receptor NNS cord-005453-4057qib7 14437 19 on on IN cord-005453-4057qib7 14437 20 the the DT cord-005453-4057qib7 14437 21 persistence persistence NN cord-005453-4057qib7 14437 22 of of IN cord-005453-4057qib7 14437 23 an an DT cord-005453-4057qib7 14437 24 FM FM NNP cord-005453-4057qib7 14437 25 . . . cord-005453-4057qib7 14438 1 In in IN cord-005453-4057qib7 14438 2 vitro vitro FW cord-005453-4057qib7 14438 3 , , , cord-005453-4057qib7 14438 4 maternal maternal JJ cord-005453-4057qib7 14438 5 NK NK NNP cord-005453-4057qib7 14438 6 cells cell NNS cord-005453-4057qib7 14438 7 showed show VBD cord-005453-4057qib7 14438 8 a a DT cord-005453-4057qib7 14438 9 higher high JJR cord-005453-4057qib7 14438 10 alloreactivity alloreactivity NN cord-005453-4057qib7 14438 11 compared compare VBN cord-005453-4057qib7 14438 12 to to IN cord-005453-4057qib7 14438 13 paternal paternal JJ cord-005453-4057qib7 14438 14 NK NK NNP cord-005453-4057qib7 14438 15 cells cell NNS cord-005453-4057qib7 14438 16 . . . cord-005453-4057qib7 14439 1 There there EX cord-005453-4057qib7 14439 2 was be VBD cord-005453-4057qib7 14439 3 no no DT cord-005453-4057qib7 14439 4 difference difference NN cord-005453-4057qib7 14439 5 in in IN cord-005453-4057qib7 14439 6 alloreactivity alloreactivity NN cord-005453-4057qib7 14439 7 whether whether IN cord-005453-4057qib7 14439 8 the the DT cord-005453-4057qib7 14439 9 mothers mother NNS cord-005453-4057qib7 14439 10 were be VBD cord-005453-4057qib7 14439 11 FM FM NNP cord-005453-4057qib7 14439 12 positive positive JJ cord-005453-4057qib7 14439 13 or or CC cord-005453-4057qib7 14439 14 negative negative JJ cord-005453-4057qib7 14439 15 , , , cord-005453-4057qib7 14439 16 suggesting suggest VBG cord-005453-4057qib7 14439 17 other other JJ cord-005453-4057qib7 14439 18 mechanisms mechanism NNS cord-005453-4057qib7 14439 19 are be VBP cord-005453-4057qib7 14439 20 responsible responsible JJ cord-005453-4057qib7 14439 21 for for IN cord-005453-4057qib7 14439 22 the the DT cord-005453-4057qib7 14439 23 superior superior JJ cord-005453-4057qib7 14439 24 outcome outcome NN cord-005453-4057qib7 14439 25 in in IN cord-005453-4057qib7 14439 26 transplantation transplantation NN cord-005453-4057qib7 14439 27 from from IN cord-005453-4057qib7 14439 28 FM FM NNP cord-005453-4057qib7 14439 29 positive positive JJ cord-005453-4057qib7 14439 30 mothers mother NNS cord-005453-4057qib7 14439 31 . . . cord-005453-4057qib7 14440 1 Disclosure disclosure NN cord-005453-4057qib7 14440 2 : : : cord-005453-4057qib7 14440 3 Nothing nothing NN cord-005453-4057qib7 14440 4 to to TO cord-005453-4057qib7 14440 5 declare declare VB cord-005453-4057qib7 14440 6 Background background NN cord-005453-4057qib7 14440 7 : : : cord-005453-4057qib7 14441 1 Although although IN cord-005453-4057qib7 14441 2 there there EX cord-005453-4057qib7 14441 3 have have VBP cord-005453-4057qib7 14441 4 been be VBN cord-005453-4057qib7 14441 5 significant significant JJ cord-005453-4057qib7 14441 6 improvements improvement NNS cord-005453-4057qib7 14441 7 with with IN cord-005453-4057qib7 14441 8 conventional conventional JJ cord-005453-4057qib7 14441 9 therapies therapy NNS cord-005453-4057qib7 14441 10 in in IN cord-005453-4057qib7 14441 11 beta beta NN cord-005453-4057qib7 14441 12 thalassemia thalassemia NN cord-005453-4057qib7 14441 13 major major JJ cord-005453-4057qib7 14441 14 , , , cord-005453-4057qib7 14441 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 14441 16 stem stem NN cord-005453-4057qib7 14441 17 cell cell NN cord-005453-4057qib7 14441 18 transplantation transplantation NN cord-005453-4057qib7 14441 19 is be VBZ cord-005453-4057qib7 14441 20 only only RB cord-005453-4057qib7 14441 21 curative curative JJ cord-005453-4057qib7 14441 22 therapy therapy NN cord-005453-4057qib7 14441 23 . . . cord-005453-4057qib7 14442 1 Related related JJ cord-005453-4057qib7 14442 2 donors donor NNS cord-005453-4057qib7 14442 3 are be VBP cord-005453-4057qib7 14442 4 preferred prefer VBN cord-005453-4057qib7 14442 5 to to TO cord-005453-4057qib7 14442 6 diminish diminish VB cord-005453-4057qib7 14442 7 transplant transplant NN cord-005453-4057qib7 14442 8 risks risk NNS cord-005453-4057qib7 14442 9 . . . cord-005453-4057qib7 14443 1 In in IN cord-005453-4057qib7 14443 2 lack lack NN cord-005453-4057qib7 14443 3 of of IN cord-005453-4057qib7 14443 4 identical identical JJ cord-005453-4057qib7 14443 5 related related JJ cord-005453-4057qib7 14443 6 donor donor NN cord-005453-4057qib7 14443 7 , , , cord-005453-4057qib7 14443 8 identical identical JJ cord-005453-4057qib7 14443 9 unrelated unrelated JJ cord-005453-4057qib7 14443 10 donors donor NNS cord-005453-4057qib7 14443 11 are be VBP cord-005453-4057qib7 14443 12 second second RB cord-005453-4057qib7 14443 13 best good JJS cord-005453-4057qib7 14443 14 choice choice NN cord-005453-4057qib7 14443 15 . . . cord-005453-4057qib7 14444 1 In in IN cord-005453-4057qib7 14444 2 this this DT cord-005453-4057qib7 14444 3 study study NN cord-005453-4057qib7 14444 4 , , , cord-005453-4057qib7 14444 5 thalassemia thalassemia NN cord-005453-4057qib7 14444 6 major major JJ cord-005453-4057qib7 14444 7 patients patient NNS cord-005453-4057qib7 14444 8 transplanted transplant VBN cord-005453-4057qib7 14444 9 from from IN cord-005453-4057qib7 14444 10 unrelated unrelated JJ cord-005453-4057qib7 14444 11 donors donor NNS cord-005453-4057qib7 14444 12 ( ( -LRB- cord-005453-4057qib7 14444 13 MUD mud NN cord-005453-4057qib7 14444 14 ) ) -RRB- cord-005453-4057qib7 14444 15 were be VBD cord-005453-4057qib7 14444 16 compared compare VBN cord-005453-4057qib7 14444 17 with with IN cord-005453-4057qib7 14444 18 thalassemic thalassemic JJ cord-005453-4057qib7 14444 19 patients patient NNS cord-005453-4057qib7 14444 20 transplanted transplant VBN cord-005453-4057qib7 14444 21 from from IN cord-005453-4057qib7 14444 22 relative relative JJ cord-005453-4057qib7 14444 23 donor donor NN cord-005453-4057qib7 14444 24 ( ( -LRB- cord-005453-4057qib7 14444 25 MRD MRD NNP cord-005453-4057qib7 14444 26 ) ) -RRB- cord-005453-4057qib7 14444 27 retrospectively retrospectively RB cord-005453-4057qib7 14444 28 . . . cord-005453-4057qib7 14445 1 Methods method NNS cord-005453-4057qib7 14445 2 : : : cord-005453-4057qib7 14445 3 45 45 CD cord-005453-4057qib7 14445 4 patients patient NNS cord-005453-4057qib7 14445 5 who who WP cord-005453-4057qib7 14445 6 were be VBD cord-005453-4057qib7 14445 7 transplanted transplant VBN cord-005453-4057qib7 14445 8 between between IN cord-005453-4057qib7 14445 9 June June NNP cord-005453-4057qib7 14445 10 2016 2016 CD cord-005453-4057qib7 14445 11 and and CC cord-005453-4057qib7 14445 12 December December NNP cord-005453-4057qib7 14445 13 2017 2017 CD cord-005453-4057qib7 14445 14 in in IN cord-005453-4057qib7 14445 15 Bahçelievler Bahçelievler NNP cord-005453-4057qib7 14445 16 Medical Medical NNP cord-005453-4057qib7 14445 17 Park Park NNP cord-005453-4057qib7 14445 18 Hospital Hospital NNP cord-005453-4057qib7 14445 19 Pediatric Pediatric NNP cord-005453-4057qib7 14445 20 Bone Bone NNP cord-005453-4057qib7 14445 21 Marrow Marrow NNP cord-005453-4057qib7 14445 22 Transplantation Transplantation NNP cord-005453-4057qib7 14445 23 Unit Unit NNP cord-005453-4057qib7 14445 24 were be VBD cord-005453-4057qib7 14445 25 evaluated evaluate VBN cord-005453-4057qib7 14445 26 retrospectively retrospectively RB cord-005453-4057qib7 14445 27 . . . cord-005453-4057qib7 14446 1 All all DT cord-005453-4057qib7 14446 2 patients patient NNS cord-005453-4057qib7 14446 3 were be VBD cord-005453-4057qib7 14446 4 classified classify VBN cord-005453-4057qib7 14446 5 according accord VBG cord-005453-4057qib7 14446 6 to to IN cord-005453-4057qib7 14446 7 pesaro pesaro NNP cord-005453-4057qib7 14446 8 risk risk NNP cord-005453-4057qib7 14446 9 classification classification NN cord-005453-4057qib7 14446 10 . . . cord-005453-4057qib7 14447 1 Thirty thirty CD cord-005453-4057qib7 14447 2 four four CD cord-005453-4057qib7 14447 3 of of IN cord-005453-4057qib7 14447 4 45 45 CD cord-005453-4057qib7 14447 5 received receive VBN cord-005453-4057qib7 14447 6 busulfan busulfan NN cord-005453-4057qib7 14447 7 , , , cord-005453-4057qib7 14447 8 fludarabine fludarabine NN cord-005453-4057qib7 14447 9 , , , cord-005453-4057qib7 14447 10 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 14447 11 , , , cord-005453-4057qib7 14447 12 thioteopa thioteopa NNP cord-005453-4057qib7 14447 13 for for IN cord-005453-4057qib7 14447 14 conditioning conditioning NN cord-005453-4057qib7 14447 15 , , , cord-005453-4057qib7 14447 16 11patients 11patients CD cord-005453-4057qib7 14447 17 received receive VBD cord-005453-4057qib7 14447 18 myeloablative myeloablative JJ cord-005453-4057qib7 14447 19 preparation preparation NN cord-005453-4057qib7 14447 20 regimen regimen NN cord-005453-4057qib7 14447 21 with with IN cord-005453-4057qib7 14447 22 treosulfan treosulfan NNP cord-005453-4057qib7 14447 23 , , , cord-005453-4057qib7 14447 24 fludarabine fludarabine NN cord-005453-4057qib7 14447 25 , , , cord-005453-4057qib7 14447 26 thiotepa thiotepa NNS cord-005453-4057qib7 14447 27 , , , cord-005453-4057qib7 14447 28 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 14447 29 . . . cord-005453-4057qib7 14448 1 All all DT cord-005453-4057qib7 14448 2 patients patient NNS cord-005453-4057qib7 14448 3 were be VBD cord-005453-4057qib7 14448 4 given give VBN cord-005453-4057qib7 14448 5 ATG ATG NNP cord-005453-4057qib7 14448 6 , , , cord-005453-4057qib7 14448 7 cyclosporine cyclosporine NN cord-005453-4057qib7 14448 8 and and CC cord-005453-4057qib7 14448 9 methoteraxate methoteraxate NN cord-005453-4057qib7 14448 10 for for IN cord-005453-4057qib7 14448 11 GVHD GVHD NNP cord-005453-4057qib7 14448 12 prophylaxis prophylaxis NN cord-005453-4057qib7 14448 13 . . . cord-005453-4057qib7 14449 1 The the DT cord-005453-4057qib7 14449 2 patients patient NNS cord-005453-4057qib7 14449 3 were be VBD cord-005453-4057qib7 14449 4 compared compare VBN cord-005453-4057qib7 14449 5 in in IN cord-005453-4057qib7 14449 6 terms term NNS cord-005453-4057qib7 14449 7 of of IN cord-005453-4057qib7 14449 8 acute acute JJ cord-005453-4057qib7 14449 9 complications complication NNS cord-005453-4057qib7 14449 10 in in IN cord-005453-4057qib7 14449 11 first first JJ cord-005453-4057qib7 14449 12 100 100 CD cord-005453-4057qib7 14449 13 days day NNS cord-005453-4057qib7 14449 14 , , , cord-005453-4057qib7 14449 15 engraftment engraftment NN cord-005453-4057qib7 14449 16 , , , cord-005453-4057qib7 14449 17 chimerism chimerism NN cord-005453-4057qib7 14449 18 , , , cord-005453-4057qib7 14449 19 acute acute JJ cord-005453-4057qib7 14449 20 and and CC cord-005453-4057qib7 14449 21 chronic chronic JJ cord-005453-4057qib7 14449 22 GVHD GVHD NNP cord-005453-4057qib7 14449 23 after after IN cord-005453-4057qib7 14449 24 transplantation transplantation NN cord-005453-4057qib7 14449 25 . . . cord-005453-4057qib7 14450 1 Results result NNS cord-005453-4057qib7 14450 2 were be VBD cord-005453-4057qib7 14450 3 evaluated evaluate VBN cord-005453-4057qib7 14450 4 with with IN cord-005453-4057qib7 14450 5 IBM IBM NNP cord-005453-4057qib7 14450 6 SPSS SPSS NNP cord-005453-4057qib7 14450 7 Statistics Statistics NNP cord-005453-4057qib7 14450 8 22 22 CD cord-005453-4057qib7 14450 9 ( ( -LRB- cord-005453-4057qib7 14450 10 IBM IBM NNP cord-005453-4057qib7 14450 11 SPSS SPSS NNP cord-005453-4057qib7 14450 12 ) ) -RRB- cord-005453-4057qib7 14450 13 program program NN cord-005453-4057qib7 14450 14 . . . cord-005453-4057qib7 14451 1 Results result NNS cord-005453-4057qib7 14451 2 : : : cord-005453-4057qib7 14452 1 A a DT cord-005453-4057qib7 14452 2 total total NN cord-005453-4057qib7 14452 3 of of IN cord-005453-4057qib7 14452 4 45 45 CD cord-005453-4057qib7 14452 5 patients patient NNS cord-005453-4057qib7 14452 6 , , , cord-005453-4057qib7 14452 7 26 26 CD cord-005453-4057qib7 14452 8 ( ( -LRB- cord-005453-4057qib7 14452 9 57.8 57.8 CD cord-005453-4057qib7 14452 10 % % NN cord-005453-4057qib7 14452 11 ) ) -RRB- cord-005453-4057qib7 14452 12 male male NN cord-005453-4057qib7 14452 13 and and CC cord-005453-4057qib7 14452 14 19 19 CD cord-005453-4057qib7 14452 15 ( ( -LRB- cord-005453-4057qib7 14452 16 42.2 42.2 CD cord-005453-4057qib7 14452 17 % % NN cord-005453-4057qib7 14452 18 ) ) -RRB- cord-005453-4057qib7 14452 19 female female NN cord-005453-4057qib7 14452 20 , , , cord-005453-4057qib7 14452 21 aged age VBN cord-005453-4057qib7 14452 22 between between IN cord-005453-4057qib7 14452 23 1 1 CD cord-005453-4057qib7 14452 24 and and CC cord-005453-4057qib7 14452 25 18 18 CD cord-005453-4057qib7 14452 26 years year NNS cord-005453-4057qib7 14453 1 ( ( -LRB- cord-005453-4057qib7 14453 2 median median NN cord-005453-4057qib7 14453 3 5 5 CD cord-005453-4057qib7 14453 4 years year NNS cord-005453-4057qib7 14453 5 ) ) -RRB- cord-005453-4057qib7 14453 6 were be VBD cord-005453-4057qib7 14453 7 evaluated evaluate VBN cord-005453-4057qib7 14453 8 . . . cord-005453-4057qib7 14454 1 Patients patient NNS cord-005453-4057qib7 14454 2 were be VBD cord-005453-4057qib7 14454 3 evaluated evaluate VBN cord-005453-4057qib7 14454 4 in in IN cord-005453-4057qib7 14454 5 two two CD cord-005453-4057qib7 14454 6 groups group NNS cord-005453-4057qib7 14454 7 as as IN cord-005453-4057qib7 14454 8 " " `` cord-005453-4057qib7 14454 9 MUD mud NN cord-005453-4057qib7 14454 10 " " '' cord-005453-4057qib7 14454 11 ( ( -LRB- cord-005453-4057qib7 14454 12 n n NN cord-005453-4057qib7 14454 13 = = SYM cord-005453-4057qib7 14454 14 15 15 CD cord-005453-4057qib7 14454 15 ) ) -RRB- cord-005453-4057qib7 14454 16 and and CC cord-005453-4057qib7 14454 17 " " `` cord-005453-4057qib7 14454 18 MRD MRD NNP cord-005453-4057qib7 14454 19 " " '' cord-005453-4057qib7 14454 20 ( ( -LRB- cord-005453-4057qib7 14454 21 n n NN cord-005453-4057qib7 14454 22 = = SYM cord-005453-4057qib7 14454 23 30 30 CD cord-005453-4057qib7 14454 24 ) ) -RRB- cord-005453-4057qib7 14454 25 groups group NNS cord-005453-4057qib7 14454 26 . . . cord-005453-4057qib7 14455 1 There there EX cord-005453-4057qib7 14455 2 was be VBD cord-005453-4057qib7 14455 3 no no DT cord-005453-4057qib7 14455 4 difference difference NN cord-005453-4057qib7 14455 5 between between IN cord-005453-4057qib7 14455 6 groups group NNS cord-005453-4057qib7 14455 7 about about IN cord-005453-4057qib7 14455 8 given give VBN cord-005453-4057qib7 14455 9 stem stem NN cord-005453-4057qib7 14455 10 cells cell NNS cord-005453-4057qib7 14455 11 ( ( -LRB- cord-005453-4057qib7 14455 12 MUD mud NN cord-005453-4057qib7 14455 13 6,16±1,07x10 6,16±1,07x10 CD cord-005453-4057qib7 14455 14 6 6 CD cord-005453-4057qib7 14455 15 /kg /kg NFP cord-005453-4057qib7 14455 16 and and CC cord-005453-4057qib7 14455 17 MRD MRD NNP cord-005453-4057qib7 14455 18 6,25±1,24x10 6,25±1,24x10 NNP cord-005453-4057qib7 14455 19 6 6 CD cord-005453-4057qib7 14455 20 / / SYM cord-005453-4057qib7 14455 21 kg kg NNP cord-005453-4057qib7 14455 22 ) ) -RRB- cord-005453-4057qib7 14455 23 . . . cord-005453-4057qib7 14456 1 Neither neither CC cord-005453-4057qib7 14456 2 significant significant JJ cord-005453-4057qib7 14456 3 difference difference NN cord-005453-4057qib7 14456 4 between between IN cord-005453-4057qib7 14456 5 different different JJ cord-005453-4057qib7 14456 6 Pesaro Pesaro NNP cord-005453-4057qib7 14456 7 risk risk NN cord-005453-4057qib7 14456 8 groups group NNS cord-005453-4057qib7 14456 9 in in IN cord-005453-4057qib7 14456 10 terms term NNS cord-005453-4057qib7 14456 11 of of IN cord-005453-4057qib7 14456 12 developing develop VBG cord-005453-4057qib7 14456 13 acute acute JJ cord-005453-4057qib7 14456 14 and and CC cord-005453-4057qib7 14456 15 chronic chronic JJ cord-005453-4057qib7 14456 16 GVHD GVHD NNP cord-005453-4057qib7 14456 17 and and CC cord-005453-4057qib7 14456 18 nor nor CC cord-005453-4057qib7 14456 19 decreased decrease VBD cord-005453-4057qib7 14456 20 chimerism chimerism NN cord-005453-4057qib7 14456 21 were be VBD cord-005453-4057qib7 14456 22 detected detect VBN cord-005453-4057qib7 14456 23 . . . cord-005453-4057qib7 14457 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 14457 2 engraftment engraftment NN cord-005453-4057qib7 14457 3 time time NN cord-005453-4057qib7 14457 4 ( ( -LRB- cord-005453-4057qib7 14457 5 16,40 16,40 CD cord-005453-4057qib7 14457 6 days day NNS cord-005453-4057qib7 14457 7 ) ) -RRB- cord-005453-4057qib7 14457 8 in in IN cord-005453-4057qib7 14457 9 MRD MRD NNP cord-005453-4057qib7 14457 10 group group NN cord-005453-4057qib7 14457 11 was be VBD cord-005453-4057qib7 14457 12 significantly significantly RB cord-005453-4057qib7 14457 13 longer long JJR cord-005453-4057qib7 14457 14 than than IN cord-005453-4057qib7 14457 15 MUD MUD NNP cord-005453-4057qib7 14457 16 group group NN cord-005453-4057qib7 14457 17 ( ( -LRB- cord-005453-4057qib7 14457 18 13,71 13,71 CD cord-005453-4057qib7 14457 19 days day NNS cord-005453-4057qib7 14457 20 ) ) -RRB- cord-005453-4057qib7 14458 1 ( ( -LRB- cord-005453-4057qib7 14458 2 p p NN cord-005453-4057qib7 14458 3 = = SYM cord-005453-4057qib7 14458 4 0.006 0.006 CD cord-005453-4057qib7 14458 5 ) ) -RRB- cord-005453-4057qib7 14459 1 but but CC cord-005453-4057qib7 14459 2 no no DT cord-005453-4057qib7 14459 3 difference difference NN cord-005453-4057qib7 14459 4 between between IN cord-005453-4057qib7 14459 5 platelet platelet NN cord-005453-4057qib7 14459 6 engraftments engraftment NNS cord-005453-4057qib7 14459 7 were be VBD cord-005453-4057qib7 14459 8 observed observe VBN cord-005453-4057qib7 14459 9 . . . cord-005453-4057qib7 14460 1 GVHD GVHD NNP cord-005453-4057qib7 14460 2 ratio ratio NN cord-005453-4057qib7 14460 3 was be VBD cord-005453-4057qib7 14460 4 33.3 33.3 CD cord-005453-4057qib7 14460 5 % % NN cord-005453-4057qib7 14460 6 in in IN cord-005453-4057qib7 14460 7 MUD MUD NNP cord-005453-4057qib7 14460 8 donor donor NN cord-005453-4057qib7 14460 9 group group NN cord-005453-4057qib7 14460 10 and and CC cord-005453-4057qib7 14460 11 13.3 13.3 CD cord-005453-4057qib7 14460 12 % % NN cord-005453-4057qib7 14460 13 in in IN cord-005453-4057qib7 14460 14 MRD MRD NNP cord-005453-4057qib7 14460 15 group group NN cord-005453-4057qib7 14460 16 and and CC cord-005453-4057qib7 14460 17 no no DT cord-005453-4057qib7 14460 18 statistically statistically RB cord-005453-4057qib7 14460 19 significant significant JJ cord-005453-4057qib7 14460 20 difference difference NN cord-005453-4057qib7 14460 21 was be VBD cord-005453-4057qib7 14460 22 found(p found(p NNP cord-005453-4057qib7 14460 23 > > XX cord-005453-4057qib7 14460 24 0.005 0.005 CD cord-005453-4057qib7 14460 25 ) ) -RRB- cord-005453-4057qib7 14460 26 . . . cord-005453-4057qib7 14461 1 The the DT cord-005453-4057qib7 14461 2 incidence incidence NN cord-005453-4057qib7 14461 3 of of IN cord-005453-4057qib7 14461 4 engraftment engraftment NN cord-005453-4057qib7 14461 5 loss loss NN cord-005453-4057qib7 14461 6 in in IN cord-005453-4057qib7 14461 7 MUD MUD NNP cord-005453-4057qib7 14461 8 group group NN cord-005453-4057qib7 14461 9 was be VBD cord-005453-4057qib7 14461 10 13.3 13.3 CD cord-005453-4057qib7 14461 11 % % NN cord-005453-4057qib7 14461 12 and and CC cord-005453-4057qib7 14461 13 36.7 36.7 CD cord-005453-4057qib7 14461 14 % % NN cord-005453-4057qib7 14461 15 in in IN cord-005453-4057qib7 14461 16 the the DT cord-005453-4057qib7 14461 17 MRD MRD NNP cord-005453-4057qib7 14461 18 group group NN cord-005453-4057qib7 14461 19 , , , cord-005453-4057qib7 14461 20 and and CC cord-005453-4057qib7 14461 21 there there EX cord-005453-4057qib7 14461 22 was be VBD cord-005453-4057qib7 14461 23 no no DT cord-005453-4057qib7 14461 24 statistically statistically RB cord-005453-4057qib7 14461 25 significant significant JJ cord-005453-4057qib7 14461 26 difference difference NN cord-005453-4057qib7 14461 27 ( ( -LRB- cord-005453-4057qib7 14461 28 p>0.05 p>0.05 NNP cord-005453-4057qib7 14461 29 ) ) -RRB- cord-005453-4057qib7 14461 30 . . . cord-005453-4057qib7 14462 1 The the DT cord-005453-4057qib7 14462 2 rate rate NN cord-005453-4057qib7 14462 3 of of IN cord-005453-4057qib7 14462 4 decreased decreased JJ cord-005453-4057qib7 14462 5 chimerism chimerism NN cord-005453-4057qib7 14462 6 was be VBD cord-005453-4057qib7 14462 7 found find VBN cord-005453-4057qib7 14462 8 to to TO cord-005453-4057qib7 14462 9 be be VB cord-005453-4057qib7 14462 10 significantly significantly RB cord-005453-4057qib7 14462 11 higher high JJR cord-005453-4057qib7 14462 12 in in IN cord-005453-4057qib7 14462 13 the the DT cord-005453-4057qib7 14462 14 MRD MRD NNP cord-005453-4057qib7 14462 15 group group NN cord-005453-4057qib7 14462 16 ( ( -LRB- cord-005453-4057qib7 14462 17 50 50 CD cord-005453-4057qib7 14462 18 % % NN cord-005453-4057qib7 14462 19 ) ) -RRB- cord-005453-4057qib7 14462 20 than than IN cord-005453-4057qib7 14462 21 in in IN cord-005453-4057qib7 14462 22 the the DT cord-005453-4057qib7 14462 23 MUD MUD NNP cord-005453-4057qib7 14462 24 group group NN cord-005453-4057qib7 14462 25 ( ( -LRB- cord-005453-4057qib7 14462 26 6.7 6.7 CD cord-005453-4057qib7 14462 27 % % NN cord-005453-4057qib7 14462 28 ) ) -RRB- cord-005453-4057qib7 14463 1 ( ( -LRB- cord-005453-4057qib7 14463 2 p:0.010 p:0.010 NNP cord-005453-4057qib7 14463 3 ; ; : cord-005453-4057qib7 14463 4 p p NN cord-005453-4057qib7 14463 5 < < XX cord-005453-4057qib7 14463 6 0.05 0.05 CD cord-005453-4057qib7 14463 7 ) ) -RRB- cord-005453-4057qib7 14463 8 . . . cord-005453-4057qib7 14464 1 The the DT cord-005453-4057qib7 14464 2 survival survival NN cord-005453-4057qib7 14464 3 rate rate NN cord-005453-4057qib7 14464 4 was be VBD cord-005453-4057qib7 14464 5 92.9 92.9 CD cord-005453-4057qib7 14464 6 % % NN cord-005453-4057qib7 14464 7 in in IN cord-005453-4057qib7 14464 8 the the DT cord-005453-4057qib7 14464 9 MUD MUD NNP cord-005453-4057qib7 14464 10 group group NN cord-005453-4057qib7 14464 11 and and CC cord-005453-4057qib7 14464 12 96.7 96.7 CD cord-005453-4057qib7 14464 13 % % NN cord-005453-4057qib7 14464 14 in in IN cord-005453-4057qib7 14464 15 the the DT cord-005453-4057qib7 14464 16 MRD MRD NNP cord-005453-4057qib7 14464 17 group group NN cord-005453-4057qib7 14464 18 . . . cord-005453-4057qib7 14465 1 The the DT cord-005453-4057qib7 14465 2 disease disease NN cord-005453-4057qib7 14465 3 - - HYPH cord-005453-4057qib7 14465 4 free free JJ cord-005453-4057qib7 14465 5 survival survival NN cord-005453-4057qib7 14465 6 rate rate NN cord-005453-4057qib7 14465 7 was be VBD cord-005453-4057qib7 14465 8 90.9 90.9 CD cord-005453-4057qib7 14465 9 % % NN cord-005453-4057qib7 14465 10 in in IN cord-005453-4057qib7 14465 11 the the DT cord-005453-4057qib7 14465 12 MUD MUD NNP cord-005453-4057qib7 14465 13 group group NN cord-005453-4057qib7 14465 14 and and CC cord-005453-4057qib7 14465 15 50 50 CD cord-005453-4057qib7 14465 16 % % NN cord-005453-4057qib7 14465 17 in in IN cord-005453-4057qib7 14465 18 the the DT cord-005453-4057qib7 14465 19 MRD MRD NNP cord-005453-4057qib7 14465 20 group group NN cord-005453-4057qib7 14465 21 . . . cord-005453-4057qib7 14466 1 The the DT cord-005453-4057qib7 14466 2 disease disease NN cord-005453-4057qib7 14466 3 - - HYPH cord-005453-4057qib7 14466 4 free free JJ cord-005453-4057qib7 14466 5 survival survival NN cord-005453-4057qib7 14466 6 of of IN cord-005453-4057qib7 14466 7 MUD MUD NNP cord-005453-4057qib7 14466 8 group group NN cord-005453-4057qib7 14466 9 was be VBD cord-005453-4057qib7 14466 10 significantly significantly RB cord-005453-4057qib7 14466 11 higher high JJR cord-005453-4057qib7 14466 12 than than IN cord-005453-4057qib7 14466 13 MRD MRD NNP cord-005453-4057qib7 14466 14 group group NN cord-005453-4057qib7 14466 15 ( ( -LRB- cord-005453-4057qib7 14466 16 p:0.010 p:0.010 NNP cord-005453-4057qib7 14466 17 ) ) -RRB- cord-005453-4057qib7 14466 18 . . . cord-005453-4057qib7 14467 1 Conclusions conclusion NNS cord-005453-4057qib7 14467 2 : : : cord-005453-4057qib7 14468 1 In in IN cord-005453-4057qib7 14468 2 our -PRON- PRP$ cord-005453-4057qib7 14468 3 study study NN cord-005453-4057qib7 14468 4 , , , cord-005453-4057qib7 14468 5 transplant transplant NN cord-005453-4057qib7 14468 6 related relate VBN cord-005453-4057qib7 14468 7 complications complication NNS cord-005453-4057qib7 14468 8 and and CC cord-005453-4057qib7 14468 9 success success NN cord-005453-4057qib7 14468 10 of of IN cord-005453-4057qib7 14468 11 transplantation transplantation NN cord-005453-4057qib7 14468 12 with with IN cord-005453-4057qib7 14468 13 both both CC cord-005453-4057qib7 14468 14 MUD MUD NNP cord-005453-4057qib7 14468 15 and and CC cord-005453-4057qib7 14468 16 MRDs MRDs NNPS cord-005453-4057qib7 14468 17 were be VBD cord-005453-4057qib7 14468 18 found find VBN cord-005453-4057qib7 14468 19 to to TO cord-005453-4057qib7 14468 20 be be VB cord-005453-4057qib7 14468 21 similar similar JJ cord-005453-4057qib7 14468 22 . . . cord-005453-4057qib7 14469 1 It -PRON- PRP cord-005453-4057qib7 14469 2 is be VBZ cord-005453-4057qib7 14469 3 promising promise VBG cord-005453-4057qib7 14469 4 for for IN cord-005453-4057qib7 14469 5 MUD mud NN cord-005453-4057qib7 14469 6 transplantations transplantation NNS cord-005453-4057qib7 14469 7 to to TO cord-005453-4057qib7 14469 8 found find VBD cord-005453-4057qib7 14469 9 lower low JJR cord-005453-4057qib7 14469 10 decreased decrease VBN cord-005453-4057qib7 14469 11 chimerism chimerism NN cord-005453-4057qib7 14469 12 and and CC cord-005453-4057qib7 14469 13 similar similar JJ cord-005453-4057qib7 14469 14 OS os NN cord-005453-4057qib7 14469 15 and and CC cord-005453-4057qib7 14469 16 DFSs dfs NNS cord-005453-4057qib7 14469 17 . . . cord-005453-4057qib7 14470 1 Based base VBN cord-005453-4057qib7 14470 2 on on IN cord-005453-4057qib7 14470 3 these these DT cord-005453-4057qib7 14470 4 results result NNS cord-005453-4057qib7 14470 5 , , , cord-005453-4057qib7 14470 6 it -PRON- PRP cord-005453-4057qib7 14470 7 was be VBD cord-005453-4057qib7 14470 8 concluded conclude VBN cord-005453-4057qib7 14470 9 that that IN cord-005453-4057qib7 14470 10 HSCT HSCT NNP cord-005453-4057qib7 14470 11 from from IN cord-005453-4057qib7 14470 12 non non JJ cord-005453-4057qib7 14470 13 - - JJ cord-005453-4057qib7 14470 14 family family JJ cord-005453-4057qib7 14470 15 donors donor NNS cord-005453-4057qib7 14470 16 , , , cord-005453-4057qib7 14470 17 especially especially RB cord-005453-4057qib7 14470 18 for for IN cord-005453-4057qib7 14470 19 patients patient NNS cord-005453-4057qib7 14470 20 incompatible incompatible JJ cord-005453-4057qib7 14470 21 with with IN cord-005453-4057qib7 14470 22 chelation chelation NN cord-005453-4057qib7 14470 23 therapy therapy NN cord-005453-4057qib7 14470 24 and and CC cord-005453-4057qib7 14470 25 had have VBD cord-005453-4057qib7 14470 26 organ organ NN cord-005453-4057qib7 14470 27 damage damage NN cord-005453-4057qib7 14470 28 , , , cord-005453-4057qib7 14470 29 transplantation transplantation NN cord-005453-4057qib7 14470 30 from from IN cord-005453-4057qib7 14470 31 unrelated unrelated JJ cord-005453-4057qib7 14470 32 identical identical JJ cord-005453-4057qib7 14470 33 donors donor NNS cord-005453-4057qib7 14470 34 can can MD cord-005453-4057qib7 14470 35 be be VB cord-005453-4057qib7 14470 36 a a DT cord-005453-4057qib7 14470 37 good good JJ cord-005453-4057qib7 14470 38 choice choice NN cord-005453-4057qib7 14470 39 . . . cord-005453-4057qib7 14471 1 Although although IN cord-005453-4057qib7 14471 2 the the DT cord-005453-4057qib7 14471 3 results result NNS cord-005453-4057qib7 14471 4 of of IN cord-005453-4057qib7 14471 5 our -PRON- PRP$ cord-005453-4057qib7 14471 6 study study NN cord-005453-4057qib7 14471 7 seem seem VBP cord-005453-4057qib7 14471 8 promising promising JJ cord-005453-4057qib7 14471 9 , , , cord-005453-4057qib7 14471 10 larger large JJR cord-005453-4057qib7 14471 11 patient patient NN cord-005453-4057qib7 14471 12 groups group NNS cord-005453-4057qib7 14471 13 and and CC cord-005453-4057qib7 14471 14 prospective prospective JJ cord-005453-4057qib7 14471 15 clinical clinical JJ cord-005453-4057qib7 14471 16 trials trial NNS cord-005453-4057qib7 14471 17 are be VBP cord-005453-4057qib7 14471 18 required require VBN cord-005453-4057qib7 14471 19 . . . cord-005453-4057qib7 14472 1 Disclosure disclosure NN cord-005453-4057qib7 14472 2 : : : cord-005453-4057qib7 14472 3 Nothing nothing NN cord-005453-4057qib7 14472 4 to to TO cord-005453-4057qib7 14472 5 declare declare VB cord-005453-4057qib7 14472 6 Background background NN cord-005453-4057qib7 14472 7 : : : cord-005453-4057qib7 14472 8 Use Use NNP cord-005453-4057qib7 14472 9 of of IN cord-005453-4057qib7 14472 10 G G NNP cord-005453-4057qib7 14472 11 - - HYPH cord-005453-4057qib7 14472 12 CSF csf NN cord-005453-4057qib7 14472 13 stimulation stimulation NN cord-005453-4057qib7 14472 14 of of IN cord-005453-4057qib7 14472 15 bone bone NN cord-005453-4057qib7 14472 16 marrow marrow NN cord-005453-4057qib7 14472 17 ( ( -LRB- cord-005453-4057qib7 14472 18 BM BM NNP cord-005453-4057qib7 14472 19 ) ) -RRB- cord-005453-4057qib7 14472 20 donors donor NNS cord-005453-4057qib7 14472 21 is be VBZ cord-005453-4057qib7 14472 22 beneficial beneficial JJ cord-005453-4057qib7 14472 23 in in IN cord-005453-4057qib7 14472 24 many many JJ cord-005453-4057qib7 14472 25 aspects aspect NNS cord-005453-4057qib7 14472 26 ; ; : cord-005453-4057qib7 14472 27 it -PRON- PRP cord-005453-4057qib7 14472 28 can can MD cord-005453-4057qib7 14472 29 enhance enhance VB cord-005453-4057qib7 14472 30 TNC TNC NNP cord-005453-4057qib7 14472 31 yield yield NN cord-005453-4057qib7 14472 32 , , , cord-005453-4057qib7 14472 33 but but CC cord-005453-4057qib7 14472 34 also also RB cord-005453-4057qib7 14472 35 have have VB cord-005453-4057qib7 14472 36 an an DT cord-005453-4057qib7 14472 37 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 14472 38 effect effect NN cord-005453-4057qib7 14472 39 on on IN cord-005453-4057qib7 14472 40 donor donor NN cord-005453-4057qib7 14472 41 T t NN cord-005453-4057qib7 14472 42 cell cell NN cord-005453-4057qib7 14472 43 function function NN cord-005453-4057qib7 14472 44 , , , cord-005453-4057qib7 14473 1 particularly particularly RB cord-005453-4057qib7 14473 2 invariant invariant JJ cord-005453-4057qib7 14473 3 natural natural JJ cord-005453-4057qib7 14473 4 killer killer NN cord-005453-4057qib7 14473 5 T t NN cord-005453-4057qib7 14473 6 ( ( -LRB- cord-005453-4057qib7 14473 7 iNKT iNKT NNP cord-005453-4057qib7 14473 8 ) ) -RRB- cord-005453-4057qib7 14473 9 cells cell NNS cord-005453-4057qib7 14473 10 expansion expansion NN cord-005453-4057qib7 14473 11 as as RB cord-005453-4057qib7 14473 12 well well RB cord-005453-4057qib7 14473 13 as as IN cord-005453-4057qib7 14473 14 APCs apc NNS cord-005453-4057qib7 14473 15 . . . cord-005453-4057qib7 14474 1 We -PRON- PRP cord-005453-4057qib7 14474 2 analyzed analyze VBD cord-005453-4057qib7 14474 3 outcomes outcome NNS cord-005453-4057qib7 14474 4 of of IN cord-005453-4057qib7 14474 5 34 34 CD cord-005453-4057qib7 14474 6 consecutive consecutive JJ cord-005453-4057qib7 14474 7 patients patient NNS cord-005453-4057qib7 14474 8 receiving receive VBG cord-005453-4057qib7 14474 9 bone bone NN cord-005453-4057qib7 14474 10 marrow marrow NN cord-005453-4057qib7 14474 11 from from IN cord-005453-4057qib7 14474 12 HLA HLA NNP cord-005453-4057qib7 14474 13 - - HYPH cord-005453-4057qib7 14474 14 haploidentical haploidentical JJ cord-005453-4057qib7 14474 15 donors donor NNS cord-005453-4057qib7 14474 16 that that WDT cord-005453-4057qib7 14474 17 were be VBD cord-005453-4057qib7 14474 18 stimulated stimulate VBN cord-005453-4057qib7 14474 19 with with IN cord-005453-4057qib7 14474 20 G G NNP cord-005453-4057qib7 14474 21 - - HYPH cord-005453-4057qib7 14474 22 CSF CSF NNP cord-005453-4057qib7 14474 23 prior prior RB cord-005453-4057qib7 14474 24 to to IN cord-005453-4057qib7 14474 25 harvest harvest NN cord-005453-4057qib7 14474 26 . . . cord-005453-4057qib7 14475 1 Methods method NNS cord-005453-4057qib7 14475 2 : : : cord-005453-4057qib7 14475 3 In in IN cord-005453-4057qib7 14475 4 the the DT cord-005453-4057qib7 14475 5 time time NN cord-005453-4057qib7 14475 6 period period NN cord-005453-4057qib7 14475 7 between between IN cord-005453-4057qib7 14475 8 05/2012 05/2012 CD cord-005453-4057qib7 14475 9 and and CC cord-005453-4057qib7 14475 10 05/ 05/ CD cord-005453-4057qib7 14475 11 2018 2018 CD cord-005453-4057qib7 14475 12 , , , cord-005453-4057qib7 14475 13 34 34 CD cord-005453-4057qib7 14475 14 patients patient NNS cord-005453-4057qib7 14475 15 received receive VBD cord-005453-4057qib7 14475 16 bone bone NN cord-005453-4057qib7 14475 17 marrow marrow NN cord-005453-4057qib7 14475 18 from from IN cord-005453-4057qib7 14475 19 donors donor NNS cord-005453-4057qib7 14475 20 stimulated stimulate VBN cord-005453-4057qib7 14475 21 with with IN cord-005453-4057qib7 14475 22 10 10 CD cord-005453-4057qib7 14475 23 ug ug NNP cord-005453-4057qib7 14475 24 / / SYM cord-005453-4057qib7 14475 25 kg kg NNP cord-005453-4057qib7 14475 26 BW BW NNP cord-005453-4057qib7 14475 27 of of IN cord-005453-4057qib7 14475 28 G G NNP cord-005453-4057qib7 14475 29 - - HYPH cord-005453-4057qib7 14475 30 CSF CSF NNP cord-005453-4057qib7 14475 31 on on IN cord-005453-4057qib7 14475 32 days day NNS cord-005453-4057qib7 14475 33 -2 -2 NNP cord-005453-4057qib7 14475 34 , , , cord-005453-4057qib7 14475 35 -1 -1 NN cord-005453-4057qib7 14475 36 and and CC cord-005453-4057qib7 14475 37 day day NN cord-005453-4057qib7 14475 38 of of IN cord-005453-4057qib7 14475 39 BM BM NNP cord-005453-4057qib7 14475 40 collection collection NN cord-005453-4057qib7 14475 41 . . . cord-005453-4057qib7 14476 1 Four four CD cord-005453-4057qib7 14476 2 patients patient NNS cord-005453-4057qib7 14476 3 ( ( -LRB- cord-005453-4057qib7 14476 4 12 12 CD cord-005453-4057qib7 14476 5 % % NN cord-005453-4057qib7 14476 6 ) ) -RRB- cord-005453-4057qib7 14476 7 received receive VBD cord-005453-4057qib7 14476 8 myeloablative myeloablative NNP cord-005453-4057qib7 14476 9 ( ( -LRB- cord-005453-4057qib7 14476 10 BuCy BuCy NNP cord-005453-4057qib7 14476 11 ) ) -RRB- cord-005453-4057qib7 14476 12 conditioning conditioning NN cord-005453-4057qib7 14476 13 , , , cord-005453-4057qib7 14476 14 one one CD cord-005453-4057qib7 14476 15 ( ( -LRB- cord-005453-4057qib7 14476 16 3 3 CD cord-005453-4057qib7 14476 17 % % NN cord-005453-4057qib7 14476 18 ) ) -RRB- cord-005453-4057qib7 14476 19 received receive VBD cord-005453-4057qib7 14476 20 TEC TEC NNP cord-005453-4057qib7 14476 21 RIC RIC NNP cord-005453-4057qib7 14476 22 conditioning conditioning NN cord-005453-4057qib7 14476 23 while while IN cord-005453-4057qib7 14476 24 29 29 CD cord-005453-4057qib7 14476 25 ( ( -LRB- cord-005453-4057qib7 14476 26 85 85 CD cord-005453-4057qib7 14476 27 % % NN cord-005453-4057qib7 14476 28 ) ) -RRB- cord-005453-4057qib7 14476 29 received receive VBD cord-005453-4057qib7 14476 30 NMA NMA NNP cord-005453-4057qib7 14476 31 ( ( -LRB- cord-005453-4057qib7 14476 32 " " `` cord-005453-4057qib7 14476 33 Baltimore Baltimore NNP cord-005453-4057qib7 14476 34 " " '' cord-005453-4057qib7 14476 35 ) ) -RRB- cord-005453-4057qib7 14476 36 conditioning conditioning NN cord-005453-4057qib7 14476 37 . . . cord-005453-4057qib7 14477 1 All all DT cord-005453-4057qib7 14477 2 patients patient NNS cord-005453-4057qib7 14477 3 received receive VBD cord-005453-4057qib7 14477 4 posttransplantation posttransplantation NN cord-005453-4057qib7 14477 5 cyclophosphamide cyclophosphamide FW cord-005453-4057qib7 14477 6 ( ( -LRB- cord-005453-4057qib7 14477 7 PTCY PTCY NNP cord-005453-4057qib7 14477 8 ) ) -RRB- cord-005453-4057qib7 14477 9 on on IN cord-005453-4057qib7 14477 10 days day NNS cord-005453-4057qib7 14477 11 +3 +3 NNP cord-005453-4057qib7 14477 12 and and CC cord-005453-4057qib7 14477 13 +4 +4 NN cord-005453-4057qib7 14477 14 , , , cord-005453-4057qib7 14477 15 tacrolimus tacrolimus NN cord-005453-4057qib7 14477 16 and and CC cord-005453-4057qib7 14477 17 MMF MMF NNP cord-005453-4057qib7 14477 18 were be VBD cord-005453-4057qib7 14477 19 started start VBN cord-005453-4057qib7 14477 20 on on IN cord-005453-4057qib7 14477 21 day day NN cord-005453-4057qib7 14477 22 +5 +5 NFP cord-005453-4057qib7 14477 23 . . . cord-005453-4057qib7 14478 1 For for IN cord-005453-4057qib7 14478 2 2 2 CD cord-005453-4057qib7 14478 3 patients patient NNS cord-005453-4057qib7 14478 4 donors donor NNS cord-005453-4057qib7 14478 5 were be VBD cord-005453-4057qib7 14478 6 fathers father NNS cord-005453-4057qib7 14478 7 , , , cord-005453-4057qib7 14478 8 11 11 CD cord-005453-4057qib7 14478 9 mothers mother NNS cord-005453-4057qib7 14478 10 , , , cord-005453-4057qib7 14478 11 9 9 CD cord-005453-4057qib7 14478 12 siblings sibling NNS cord-005453-4057qib7 14478 13 and and CC cord-005453-4057qib7 14478 14 12 12 CD cord-005453-4057qib7 14478 15 children child NNS cord-005453-4057qib7 14478 16 . . . cord-005453-4057qib7 14479 1 Results result NNS cord-005453-4057qib7 14479 2 : : : cord-005453-4057qib7 14480 1 Median median JJ cord-005453-4057qib7 14480 2 age age NN cord-005453-4057qib7 14480 3 was be VBD cord-005453-4057qib7 14480 4 43 43 CD cord-005453-4057qib7 14480 5 years year NNS cord-005453-4057qib7 14480 6 ( ( -LRB- cord-005453-4057qib7 14480 7 20 20 CD cord-005453-4057qib7 14480 8 - - SYM cord-005453-4057qib7 14480 9 63 63 CD cord-005453-4057qib7 14480 10 ) ) -RRB- cord-005453-4057qib7 14480 11 , , , cord-005453-4057qib7 14480 12 there there EX cord-005453-4057qib7 14480 13 were be VBD cord-005453-4057qib7 14480 14 14 14 CD cord-005453-4057qib7 14480 15 female female JJ cord-005453-4057qib7 14480 16 and and CC cord-005453-4057qib7 14480 17 20 20 CD cord-005453-4057qib7 14480 18 male male JJ cord-005453-4057qib7 14480 19 patients patient NNS cord-005453-4057qib7 14480 20 . . . cord-005453-4057qib7 14481 1 Twelve twelve CD cord-005453-4057qib7 14481 2 patients patient NNS cord-005453-4057qib7 14481 3 had have VBD cord-005453-4057qib7 14481 4 AML AML NNP cord-005453-4057qib7 14481 5 , , , cord-005453-4057qib7 14481 6 10 10 CD cord-005453-4057qib7 14481 7 Hodgkin Hodgkin NNP cord-005453-4057qib7 14481 8 lymphoma lymphoma NN cord-005453-4057qib7 14481 9 , , , cord-005453-4057qib7 14481 10 5 5 CD cord-005453-4057qib7 14481 11 ALL all DT cord-005453-4057qib7 14481 12 , , , cord-005453-4057qib7 14481 13 3 3 CD cord-005453-4057qib7 14481 14 MDS MDS NNP cord-005453-4057qib7 14481 15 , , , cord-005453-4057qib7 14481 16 3 3 CD cord-005453-4057qib7 14481 17 NHL NHL NNP cord-005453-4057qib7 14481 18 and and CC cord-005453-4057qib7 14481 19 1 1 CD cord-005453-4057qib7 14481 20 CML CML NNP cord-005453-4057qib7 14481 21 . . . cord-005453-4057qib7 14482 1 Median median JJ cord-005453-4057qib7 14482 2 number number NN cord-005453-4057qib7 14482 3 of of IN cord-005453-4057qib7 14482 4 infused infuse VBN cord-005453-4057qib7 14482 5 TNC TNC NNP cord-005453-4057qib7 14482 6 in in IN cord-005453-4057qib7 14482 7 graft graft NN cord-005453-4057qib7 14482 8 was be VBD cord-005453-4057qib7 14482 9 4.7x10 4.7x10 CD cord-005453-4057qib7 14482 10 8 8 CD cord-005453-4057qib7 14483 1 /kg /kg NFP cord-005453-4057qib7 14483 2 BW BW NNP cord-005453-4057qib7 14483 3 ( ( -LRB- cord-005453-4057qib7 14483 4 1.8 1.8 CD cord-005453-4057qib7 14483 5 - - SYM cord-005453-4057qib7 14483 6 8.2 8.2 CD cord-005453-4057qib7 14483 7 ) ) -RRB- cord-005453-4057qib7 14483 8 and and CC cord-005453-4057qib7 14483 9 CD34 CD34 NNP cord-005453-4057qib7 14484 1 + + CC cord-005453-4057qib7 14484 2 cells cell NNS cord-005453-4057qib7 14484 3 1.9 1.9 CD cord-005453-4057qib7 14484 4 x10 x10 CD cord-005453-4057qib7 14484 5 6 6 CD cord-005453-4057qib7 14485 1 /kg /kg NFP cord-005453-4057qib7 14485 2 BW BW NNP cord-005453-4057qib7 14485 3 ( ( -LRB- cord-005453-4057qib7 14485 4 1 1 CD cord-005453-4057qib7 14485 5 - - SYM cord-005453-4057qib7 14485 6 4.5 4.5 CD cord-005453-4057qib7 14485 7 ) ) -RRB- cord-005453-4057qib7 14485 8 . . . cord-005453-4057qib7 14486 1 After after IN cord-005453-4057qib7 14486 2 median median NN cord-005453-4057qib7 14486 3 follow follow NN cord-005453-4057qib7 14486 4 up up IN cord-005453-4057qib7 14486 5 of of IN cord-005453-4057qib7 14486 6 397 397 CD cord-005453-4057qib7 14486 7 days day NNS cord-005453-4057qib7 14486 8 ( ( -LRB- cord-005453-4057qib7 14486 9 range range VBP cord-005453-4057qib7 14486 10 26 26 CD cord-005453-4057qib7 14486 11 - - SYM cord-005453-4057qib7 14486 12 2139 2139 CD cord-005453-4057qib7 14486 13 ) ) -RRB- cord-005453-4057qib7 14486 14 , , , cord-005453-4057qib7 14486 15 overall overall JJ cord-005453-4057qib7 14486 16 survival survival NN cord-005453-4057qib7 14486 17 was be VBD cord-005453-4057qib7 14486 18 57 57 CD cord-005453-4057qib7 14486 19 % % NN cord-005453-4057qib7 14486 20 , , , cord-005453-4057qib7 14486 21 with with IN cord-005453-4057qib7 14486 22 median median JJ cord-005453-4057qib7 14486 23 survival survival NN cord-005453-4057qib7 14486 24 of of IN cord-005453-4057qib7 14486 25 71 71 CD cord-005453-4057qib7 14486 26 months month NNS cord-005453-4057qib7 14486 27 . . . cord-005453-4057qib7 14487 1 Engraftment Engraftment NNP cord-005453-4057qib7 14487 2 was be VBD cord-005453-4057qib7 14487 3 established establish VBN cord-005453-4057qib7 14487 4 in in IN cord-005453-4057qib7 14487 5 29 29 CD cord-005453-4057qib7 14487 6 ( ( -LRB- cord-005453-4057qib7 14487 7 85 85 CD cord-005453-4057qib7 14487 8 % % NN cord-005453-4057qib7 14487 9 ) ) -RRB- cord-005453-4057qib7 14487 10 patients patient NNS cord-005453-4057qib7 14487 11 , , , cord-005453-4057qib7 14487 12 2 2 CD cord-005453-4057qib7 14487 13 ( ( -LRB- cord-005453-4057qib7 14487 14 6 6 CD cord-005453-4057qib7 14487 15 % % NN cord-005453-4057qib7 14487 16 ) ) -RRB- cord-005453-4057qib7 14487 17 had have VBD cord-005453-4057qib7 14487 18 primary primary JJ cord-005453-4057qib7 14487 19 rejection rejection NN cord-005453-4057qib7 14487 20 and and CC cord-005453-4057qib7 14487 21 3 3 CD cord-005453-4057qib7 14487 22 patients patient NNS cord-005453-4057qib7 14487 23 ( ( -LRB- cord-005453-4057qib7 14487 24 9 9 CD cord-005453-4057qib7 14487 25 % % NN cord-005453-4057qib7 14487 26 ) ) -RRB- cord-005453-4057qib7 14487 27 died die VBD cord-005453-4057qib7 14487 28 in in IN cord-005453-4057qib7 14487 29 sepsis sepsis NN cord-005453-4057qib7 14487 30 prior prior RB cord-005453-4057qib7 14487 31 to to IN cord-005453-4057qib7 14487 32 engraftment engraftment NN cord-005453-4057qib7 14487 33 . . . cord-005453-4057qib7 14488 1 Of of IN cord-005453-4057qib7 14488 2 29 29 CD cord-005453-4057qib7 14488 3 patients patient NNS cord-005453-4057qib7 14488 4 that that WDT cord-005453-4057qib7 14488 5 engrafted engraft VBD cord-005453-4057qib7 14488 6 , , , cord-005453-4057qib7 14488 7 further further RB cord-005453-4057qib7 14488 8 3 3 CD cord-005453-4057qib7 14488 9 ( ( -LRB- cord-005453-4057qib7 14488 10 9 9 CD cord-005453-4057qib7 14488 11 % % NN cord-005453-4057qib7 14488 12 ) ) -RRB- cord-005453-4057qib7 14488 13 patients patient NNS cord-005453-4057qib7 14488 14 had have VBD cord-005453-4057qib7 14488 15 secondary secondary JJ cord-005453-4057qib7 14488 16 rejection rejection NN cord-005453-4057qib7 14488 17 , , , cord-005453-4057qib7 14488 18 two two CD cord-005453-4057qib7 14488 19 of of IN cord-005453-4057qib7 14488 20 them -PRON- PRP cord-005453-4057qib7 14488 21 were be VBD cord-005453-4057qib7 14488 22 transplanted transplant VBN cord-005453-4057qib7 14488 23 again again RB cord-005453-4057qib7 14488 24 from from IN cord-005453-4057qib7 14488 25 a a DT cord-005453-4057qib7 14488 26 haploidentical haploidentical JJ cord-005453-4057qib7 14488 27 donor donor NN cord-005453-4057qib7 14488 28 , , , cord-005453-4057qib7 14488 29 both both DT cord-005453-4057qib7 14488 30 using use VBG cord-005453-4057qib7 14488 31 PBSC PBSC NNP cord-005453-4057qib7 14488 32 as as IN cord-005453-4057qib7 14488 33 a a DT cord-005453-4057qib7 14488 34 source source NN cord-005453-4057qib7 14488 35 of of IN cord-005453-4057qib7 14488 36 graft graft NN cord-005453-4057qib7 14488 37 . . . cord-005453-4057qib7 14489 1 Median median JJ cord-005453-4057qib7 14489 2 time time NN cord-005453-4057qib7 14489 3 to to IN cord-005453-4057qib7 14489 4 neutrophil neutrophil NN cord-005453-4057qib7 14489 5 recovery recovery NN cord-005453-4057qib7 14490 1 ( ( -LRB- cord-005453-4057qib7 14490 2 ANC>500 ANC>500 NNP cord-005453-4057qib7 14490 3 ) ) -RRB- cord-005453-4057qib7 14490 4 was be VBD cord-005453-4057qib7 14490 5 23 23 CD cord-005453-4057qib7 14490 6 days day NNS cord-005453-4057qib7 14490 7 ( ( -LRB- cord-005453-4057qib7 14490 8 12 12 CD cord-005453-4057qib7 14490 9 - - SYM cord-005453-4057qib7 14490 10 36 36 CD cord-005453-4057qib7 14490 11 ) ) -RRB- cord-005453-4057qib7 14490 12 , , , cord-005453-4057qib7 14490 13 while while IN cord-005453-4057qib7 14490 14 median median JJ cord-005453-4057qib7 14490 15 time time NN cord-005453-4057qib7 14490 16 to to IN cord-005453-4057qib7 14490 17 platelet platelet NN cord-005453-4057qib7 14490 18 recovery recovery NN cord-005453-4057qib7 14490 19 ( ( -LRB- cord-005453-4057qib7 14490 20 PLT>20x10 plt>20x10 NN cord-005453-4057qib7 14490 21 9 9 CD cord-005453-4057qib7 14490 22 /L /L , cord-005453-4057qib7 14490 23 ) ) -RRB- cord-005453-4057qib7 14490 24 was be VBD cord-005453-4057qib7 14490 25 30 30 CD cord-005453-4057qib7 14490 26 days day NNS cord-005453-4057qib7 14490 27 ( ( -LRB- cord-005453-4057qib7 14490 28 12 12 CD cord-005453-4057qib7 14490 29 - - SYM cord-005453-4057qib7 14490 30 72 72 CD cord-005453-4057qib7 14490 31 ) ) -RRB- cord-005453-4057qib7 14490 32 in in IN cord-005453-4057qib7 14490 33 evaluable evaluable JJ cord-005453-4057qib7 14490 34 patients patient NNS cord-005453-4057qib7 14490 35 . . . cord-005453-4057qib7 14491 1 Cumulative cumulative JJ cord-005453-4057qib7 14491 2 incidence incidence NN cord-005453-4057qib7 14491 3 of of IN cord-005453-4057qib7 14491 4 aGVHD aGVHD NNP cord-005453-4057qib7 14491 5 II II NNP cord-005453-4057qib7 14491 6 - - HYPH cord-005453-4057qib7 14491 7 IV IV NNP cord-005453-4057qib7 14491 8 was be VBD cord-005453-4057qib7 14491 9 27.7 27.7 CD cord-005453-4057qib7 14491 10 % % NN cord-005453-4057qib7 14491 11 ( ( -LRB- cord-005453-4057qib7 14491 12 95 95 CD cord-005453-4057qib7 14491 13 % % NN cord-005453-4057qib7 14491 14 CI CI NNP cord-005453-4057qib7 14491 15 , , , cord-005453-4057qib7 14491 16 13 13 CD cord-005453-4057qib7 14491 17 - - HYPH cord-005453-4057qib7 14491 18 44);of 44);of NNS cord-005453-4057qib7 14491 19 note note NN cord-005453-4057qib7 14491 20 is be VBZ cord-005453-4057qib7 14491 21 that that DT cord-005453-4057qib7 14491 22 of of IN cord-005453-4057qib7 14491 23 9 9 CD cord-005453-4057qib7 14491 24 patients patient NNS cord-005453-4057qib7 14491 25 that that WDT cord-005453-4057qib7 14491 26 developed develop VBD cord-005453-4057qib7 14491 27 aGVHD aGVHD NNP cord-005453-4057qib7 14491 28 only only RB cord-005453-4057qib7 14491 29 one one CD cord-005453-4057qib7 14491 30 had have VBD cord-005453-4057qib7 14491 31 grade grade NN cord-005453-4057qib7 14491 32 III III NNP cord-005453-4057qib7 14491 33 , , , cord-005453-4057qib7 14491 34 while while IN cord-005453-4057qib7 14491 35 remaining remain VBG cord-005453-4057qib7 14491 36 8 8 CD cord-005453-4057qib7 14491 37 patients patient NNS cord-005453-4057qib7 14491 38 had have VBD cord-005453-4057qib7 14491 39 grade grade NN cord-005453-4057qib7 14491 40 II II NNP cord-005453-4057qib7 14491 41 . . . cord-005453-4057qib7 14492 1 Cumulative cumulative JJ cord-005453-4057qib7 14492 2 incidence incidence NN cord-005453-4057qib7 14492 3 of of IN cord-005453-4057qib7 14492 4 cGVHD cGVHD NNP cord-005453-4057qib7 14493 1 requiring require VBG cord-005453-4057qib7 14493 2 treatment treatment NN cord-005453-4057qib7 14493 3 was be VBD cord-005453-4057qib7 14493 4 6.9 6.9 CD cord-005453-4057qib7 14493 5 % % NN cord-005453-4057qib7 14493 6 ( ( -LRB- cord-005453-4057qib7 14493 7 95 95 CD cord-005453-4057qib7 14493 8 % % NN cord-005453-4057qib7 14493 9 CI CI NNP cord-005453-4057qib7 14493 10 , , , cord-005453-4057qib7 14493 11 [ [ -LRB- cord-005453-4057qib7 14493 12 1 1 CD cord-005453-4057qib7 14493 13 ] ] -RRB- cord-005453-4057qib7 14493 14 [ [ -LRB- cord-005453-4057qib7 14493 15 2 2 CD cord-005453-4057qib7 14493 16 ] ] -RRB- cord-005453-4057qib7 14493 17 [ [ -LRB- cord-005453-4057qib7 14493 18 3 3 CD cord-005453-4057qib7 14493 19 ] ] -RRB- cord-005453-4057qib7 14493 20 [ [ -LRB- cord-005453-4057qib7 14493 21 4 4 CD cord-005453-4057qib7 14493 22 ] ] -RRB- cord-005453-4057qib7 14493 23 [ [ -LRB- cord-005453-4057qib7 14493 24 5 5 CD cord-005453-4057qib7 14493 25 ] ] -RRB- cord-005453-4057qib7 14493 26 [ [ -LRB- cord-005453-4057qib7 14493 27 6 6 CD cord-005453-4057qib7 14493 28 ] ] -RRB- cord-005453-4057qib7 14493 29 [ [ -LRB- cord-005453-4057qib7 14493 30 7 7 CD cord-005453-4057qib7 14493 31 ] ] -RRB- cord-005453-4057qib7 14493 32 [ [ -LRB- cord-005453-4057qib7 14493 33 8 8 CD cord-005453-4057qib7 14493 34 ] ] -RRB- cord-005453-4057qib7 14493 35 [ [ -LRB- cord-005453-4057qib7 14493 36 9 9 CD cord-005453-4057qib7 14493 37 ] ] -RRB- cord-005453-4057qib7 14493 38 [ [ -LRB- cord-005453-4057qib7 14493 39 10 10 CD cord-005453-4057qib7 14493 40 ] ] -RRB- cord-005453-4057qib7 14493 41 [ [ -LRB- cord-005453-4057qib7 14493 42 11 11 CD cord-005453-4057qib7 14493 43 ] ] -RRB- cord-005453-4057qib7 14493 44 [ [ -LRB- cord-005453-4057qib7 14493 45 12 12 CD cord-005453-4057qib7 14493 46 ] ] -RRB- cord-005453-4057qib7 14493 47 [ [ -LRB- cord-005453-4057qib7 14493 48 13 13 CD cord-005453-4057qib7 14493 49 ] ] -RRB- cord-005453-4057qib7 14493 50 [ [ -LRB- cord-005453-4057qib7 14493 51 14 14 CD cord-005453-4057qib7 14493 52 ] ] -RRB- cord-005453-4057qib7 14493 53 [ [ -LRB- cord-005453-4057qib7 14493 54 15 15 CD cord-005453-4057qib7 14493 55 ] ] -RRB- cord-005453-4057qib7 14493 56 [ [ -LRB- cord-005453-4057qib7 14493 57 16 16 CD cord-005453-4057qib7 14493 58 ] ] -RRB- cord-005453-4057qib7 14493 59 [ [ -LRB- cord-005453-4057qib7 14493 60 17 17 CD cord-005453-4057qib7 14493 61 ] ] -RRB- cord-005453-4057qib7 14493 62 [ [ -LRB- cord-005453-4057qib7 14493 63 18 18 CD cord-005453-4057qib7 14493 64 ] ] -RRB- cord-005453-4057qib7 14493 65 [ [ -LRB- cord-005453-4057qib7 14493 66 19 19 CD cord-005453-4057qib7 14493 67 ] ] -RRB- cord-005453-4057qib7 14493 68 [ [ -LRB- cord-005453-4057qib7 14493 69 20 20 CD cord-005453-4057qib7 14493 70 ] ] -RRB- cord-005453-4057qib7 14493 71 . . . cord-005453-4057qib7 14494 1 Cumulative cumulative JJ cord-005453-4057qib7 14494 2 incidence incidence NN cord-005453-4057qib7 14494 3 of of IN cord-005453-4057qib7 14494 4 relapse relapse NN cord-005453-4057qib7 14494 5 was be VBD cord-005453-4057qib7 14494 6 36.1 36.1 CD cord-005453-4057qib7 14494 7 % % NN cord-005453-4057qib7 14494 8 ( ( -LRB- cord-005453-4057qib7 14494 9 95 95 CD cord-005453-4057qib7 14494 10 % % NN cord-005453-4057qib7 14494 11 CI CI NNP cord-005453-4057qib7 14494 12 , , , cord-005453-4057qib7 14494 13 20 20 CD cord-005453-4057qib7 14494 14 - - SYM cord-005453-4057qib7 14494 15 52 52 CD cord-005453-4057qib7 14494 16 ) ) -RRB- cord-005453-4057qib7 14494 17 and and CC cord-005453-4057qib7 14494 18 TRM TRM NNP cord-005453-4057qib7 14494 19 was be VBD cord-005453-4057qib7 14494 20 25.2 25.2 CD cord-005453-4057qib7 14494 21 % % NN cord-005453-4057qib7 14494 22 ( ( -LRB- cord-005453-4057qib7 14494 23 95 95 CD cord-005453-4057qib7 14494 24 % % NN cord-005453-4057qib7 14494 25 CI CI NNP cord-005453-4057qib7 14494 26 , , , cord-005453-4057qib7 14494 27 11 11 CD cord-005453-4057qib7 14494 28 - - SYM cord-005453-4057qib7 14494 29 41 41 CD cord-005453-4057qib7 14494 30 ) ) -RRB- cord-005453-4057qib7 14494 31 . . . cord-005453-4057qib7 14495 1 Conclusions conclusion NNS cord-005453-4057qib7 14495 2 : : : cord-005453-4057qib7 14496 1 The the DT cord-005453-4057qib7 14496 2 use use NN cord-005453-4057qib7 14496 3 of of IN cord-005453-4057qib7 14496 4 G G NNP cord-005453-4057qib7 14496 5 - - HYPH cord-005453-4057qib7 14496 6 CSF csf NN cord-005453-4057qib7 14496 7 mobilized mobilize VBD cord-005453-4057qib7 14496 8 BM BM NNP cord-005453-4057qib7 14496 9 graft graft NN cord-005453-4057qib7 14496 10 in in IN cord-005453-4057qib7 14496 11 the the DT cord-005453-4057qib7 14496 12 HLA HLA NNP cord-005453-4057qib7 14496 13 - - HYPH cord-005453-4057qib7 14496 14 haploidentical haploidentical JJ cord-005453-4057qib7 14496 15 setting setting NN cord-005453-4057qib7 14496 16 with with IN cord-005453-4057qib7 14496 17 PTCY PTCY NNP cord-005453-4057qib7 14496 18 has have VBZ cord-005453-4057qib7 14496 19 proven prove VBN cord-005453-4057qib7 14496 20 to to TO cord-005453-4057qib7 14496 21 be be VB cord-005453-4057qib7 14496 22 useful useful JJ cord-005453-4057qib7 14496 23 to to IN cord-005453-4057qib7 14496 24 us -PRON- PRP cord-005453-4057qib7 14496 25 , , , cord-005453-4057qib7 14496 26 not not RB cord-005453-4057qib7 14496 27 only only RB cord-005453-4057qib7 14496 28 in in IN cord-005453-4057qib7 14496 29 terms term NNS cord-005453-4057qib7 14496 30 of of IN cord-005453-4057qib7 14496 31 TNC TNC NNP cord-005453-4057qib7 14496 32 yield yield NN cord-005453-4057qib7 14496 33 which which WDT cord-005453-4057qib7 14496 34 was be VBD cord-005453-4057qib7 14496 35 more more JJR cord-005453-4057qib7 14496 36 than than IN cord-005453-4057qib7 14496 37 satisfactory satisfactory JJ cord-005453-4057qib7 14496 38 and and CC cord-005453-4057qib7 14496 39 contributed contribute VBD cord-005453-4057qib7 14496 40 to to TO cord-005453-4057qib7 14496 41 adequate adequate VB cord-005453-4057qib7 14496 42 hematological hematological JJ cord-005453-4057qib7 14496 43 recovery recovery NN cord-005453-4057qib7 14496 44 , , , cord-005453-4057qib7 14496 45 but but CC cord-005453-4057qib7 14496 46 also also RB cord-005453-4057qib7 14496 47 in in IN cord-005453-4057qib7 14496 48 the the DT cord-005453-4057qib7 14496 49 excellent excellent JJ cord-005453-4057qib7 14496 50 control control NN cord-005453-4057qib7 14496 51 of of IN cord-005453-4057qib7 14496 52 both both CC cord-005453-4057qib7 14496 53 acute acute JJ cord-005453-4057qib7 14496 54 and and CC cord-005453-4057qib7 14496 55 chronic chronic JJ cord-005453-4057qib7 14496 56 GVHD GVHD NNP cord-005453-4057qib7 14496 57 , , , cord-005453-4057qib7 14496 58 with with IN cord-005453-4057qib7 14496 59 most most JJS cord-005453-4057qib7 14496 60 patients patient NNS cord-005453-4057qib7 14496 61 developing develop VBG cord-005453-4057qib7 14496 62 aGVHD agvhd NN cord-005453-4057qib7 14496 63 of of IN cord-005453-4057qib7 14496 64 grade grade NN cord-005453-4057qib7 14496 65 II II NNP cord-005453-4057qib7 14496 66 and and CC cord-005453-4057qib7 14496 67 only only RB cord-005453-4057qib7 14496 68 one one CD cord-005453-4057qib7 14496 69 grade grade NN cord-005453-4057qib7 14496 70 III III NNP cord-005453-4057qib7 14496 71 ( ( -LRB- cord-005453-4057qib7 14496 72 actually actually RB cord-005453-4057qib7 14496 73 developed develop VBN cord-005453-4057qib7 14496 74 only only RB cord-005453-4057qib7 14496 75 after after IN cord-005453-4057qib7 14496 76 DLI DLI NNP cord-005453-4057qib7 14496 77 given give VBN cord-005453-4057qib7 14496 78 for for IN cord-005453-4057qib7 14496 79 decreasing decrease VBG cord-005453-4057qib7 14496 80 chimerism chimerism NN cord-005453-4057qib7 14496 81 ) ) -RRB- cord-005453-4057qib7 14496 82 . . . cord-005453-4057qib7 14497 1 Comparative comparative JJ cord-005453-4057qib7 14497 2 studies study NNS cord-005453-4057qib7 14497 3 are be VBP cord-005453-4057qib7 14497 4 of of IN cord-005453-4057qib7 14497 5 course course NN cord-005453-4057qib7 14497 6 warranted warrant VBN cord-005453-4057qib7 14497 7 to to TO cord-005453-4057qib7 14497 8 prove prove VB cord-005453-4057qib7 14497 9 benefit benefit NN cord-005453-4057qib7 14497 10 , , , cord-005453-4057qib7 14497 11 but but CC cord-005453-4057qib7 14497 12 this this DT cord-005453-4057qib7 14497 13 data data NN cord-005453-4057qib7 14497 14 contributes contribute VBZ cord-005453-4057qib7 14497 15 to to IN cord-005453-4057qib7 14497 16 the the DT cord-005453-4057qib7 14497 17 growing grow VBG cord-005453-4057qib7 14497 18 body body NN cord-005453-4057qib7 14497 19 of of IN cord-005453-4057qib7 14497 20 evidence evidence NN cord-005453-4057qib7 14497 21 that that WDT cord-005453-4057qib7 14497 22 indeed indeed RB cord-005453-4057qib7 14497 23 donor donor NN cord-005453-4057qib7 14497 24 stem stem NN cord-005453-4057qib7 14497 25 cell cell NN cord-005453-4057qib7 14497 26 stimulation stimulation NN cord-005453-4057qib7 14497 27 with with IN cord-005453-4057qib7 14497 28 G G NNP cord-005453-4057qib7 14497 29 - - HYPH cord-005453-4057qib7 14497 30 CSF CSF NNP cord-005453-4057qib7 14497 31 has have VBZ cord-005453-4057qib7 14497 32 potentially potentially RB cord-005453-4057qib7 14497 33 powerful powerful JJ cord-005453-4057qib7 14497 34 immunomodulatory immunomodulatory JJ cord-005453-4057qib7 14497 35 effect effect NN cord-005453-4057qib7 14497 36 . . . cord-005453-4057qib7 14498 1 Disclosure disclosure NN cord-005453-4057qib7 14498 2 : : : cord-005453-4057qib7 14498 3 Nothing nothing NN cord-005453-4057qib7 14498 4 to to TO cord-005453-4057qib7 14498 5 disclose disclose VB cord-005453-4057qib7 14498 6 P674 p674 CD cord-005453-4057qib7 14498 7 other other JJ cord-005453-4057qib7 14498 8 - - HYPH cord-005453-4057qib7 14498 9 relative relative JJ cord-005453-4057qib7 14498 10 donors donor NNS cord-005453-4057qib7 14498 11 as as IN cord-005453-4057qib7 14498 12 a a DT cord-005453-4057qib7 14498 13 reliable reliable JJ cord-005453-4057qib7 14498 14 bank bank NN cord-005453-4057qib7 14498 15 for for IN cord-005453-4057qib7 14498 16 allogeneic allogeneic NN cord-005453-4057qib7 14498 17 hsct hsct NNP cord-005453-4057qib7 14498 18 in in IN cord-005453-4057qib7 14498 19 countries country NNS cord-005453-4057qib7 14498 20 with with IN cord-005453-4057qib7 14498 21 culturally culturally RB cord-005453-4057qib7 14498 22 accepted accept VBN cord-005453-4057qib7 14498 23 cousin cousin NN cord-005453-4057qib7 14498 24 - - HYPH cord-005453-4057qib7 14498 25 cousin cousin NN cord-005453-4057qib7 14498 26 marriages marriage NNS cord-005453-4057qib7 14498 27 : : : cord-005453-4057qib7 14498 28 A a DT cord-005453-4057qib7 14498 29 two two CD cord-005453-4057qib7 14498 30 - - HYPH cord-005453-4057qib7 14498 31 year year NN cord-005453-4057qib7 14498 32 report report NN cord-005453-4057qib7 14498 33 from from IN cord-005453-4057qib7 14498 34 a a DT cord-005453-4057qib7 14498 35 pediatric pediatric JJ cord-005453-4057qib7 14498 36 center center NN cord-005453-4057qib7 14498 37 in in IN cord-005453-4057qib7 14498 38 Iran Iran NNP cord-005453-4057qib7 14498 39 Background Background NNP cord-005453-4057qib7 14498 40 : : : cord-005453-4057qib7 14499 1 Although although IN cord-005453-4057qib7 14499 2 the the DT cord-005453-4057qib7 14499 3 optimal optimal JJ cord-005453-4057qib7 14499 4 donors donor NNS cord-005453-4057qib7 14499 5 for for IN cord-005453-4057qib7 14499 6 patients patient NNS cord-005453-4057qib7 14499 7 undergoing undergo VBG cord-005453-4057qib7 14499 8 allogeneic allogeneic IN cord-005453-4057qib7 14499 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 14499 10 stem stem NN cord-005453-4057qib7 14499 11 cell cell NN cord-005453-4057qib7 14499 12 transplantation transplantation NN cord-005453-4057qib7 14499 13 ( ( -LRB- cord-005453-4057qib7 14499 14 allo allo NN cord-005453-4057qib7 14499 15 - - HYPH cord-005453-4057qib7 14499 16 HSCT HSCT NNP cord-005453-4057qib7 14499 17 ) ) -RRB- cord-005453-4057qib7 14499 18 are be VBP cord-005453-4057qib7 14499 19 fully fully RB cord-005453-4057qib7 14499 20 - - HYPH cord-005453-4057qib7 14499 21 matched match VBN cord-005453-4057qib7 14499 22 siblings sibling NNS cord-005453-4057qib7 14499 23 , , , cord-005453-4057qib7 14499 24 the the DT cord-005453-4057qib7 14499 25 cousincousin cousincousin NNP cord-005453-4057qib7 14499 26 ( ( -LRB- cord-005453-4057qib7 14499 27 consanguineous consanguineous JJ cord-005453-4057qib7 14499 28 ) ) -RRB- cord-005453-4057qib7 14499 29 marriages marriage NNS cord-005453-4057qib7 14499 30 in in IN cord-005453-4057qib7 14499 31 some some DT cord-005453-4057qib7 14499 32 countries country NNS cord-005453-4057qib7 14499 33 have have VBP cord-005453-4057qib7 14499 34 extended extend VBN cord-005453-4057qib7 14499 35 the the DT cord-005453-4057qib7 14499 36 chance chance NN cord-005453-4057qib7 14499 37 to to TO cord-005453-4057qib7 14499 38 find find VB cord-005453-4057qib7 14499 39 a a DT cord-005453-4057qib7 14499 40 matched match VBN cord-005453-4057qib7 14499 41 donor donor NN cord-005453-4057qib7 14499 42 for for IN cord-005453-4057qib7 14499 43 the the DT cord-005453-4057qib7 14499 44 HSCTrecipient hsctrecipient NN cord-005453-4057qib7 14499 45 . . . cord-005453-4057qib7 14500 1 In in IN cord-005453-4057qib7 14500 2 this this DT cord-005453-4057qib7 14500 3 study study NN cord-005453-4057qib7 14500 4 , , , cord-005453-4057qib7 14500 5 an an DT cord-005453-4057qib7 14500 6 outcome outcome NN cord-005453-4057qib7 14500 7 analysis analysis NN cord-005453-4057qib7 14500 8 of of IN cord-005453-4057qib7 14500 9 transplanted transplanted JJ cord-005453-4057qib7 14500 10 patients patient NNS cord-005453-4057qib7 14500 11 receiving receive VBG cord-005453-4057qib7 14500 12 stem stem NN cord-005453-4057qib7 14500 13 cells cell NNS cord-005453-4057qib7 14500 14 from from IN cord-005453-4057qib7 14500 15 their -PRON- PRP$ cord-005453-4057qib7 14500 16 relatives relative NNS cord-005453-4057qib7 14500 17 other other JJ cord-005453-4057qib7 14500 18 than than IN cord-005453-4057qib7 14500 19 siblings sibling NNS cord-005453-4057qib7 14500 20 ( ( -LRB- cord-005453-4057qib7 14500 21 other other JJ cord-005453-4057qib7 14500 22 - - HYPH cord-005453-4057qib7 14500 23 relatives relative NNS cord-005453-4057qib7 14500 24 or or CC cord-005453-4057qib7 14500 25 non non JJ cord-005453-4057qib7 14500 26 - - JJ cord-005453-4057qib7 14500 27 sibling sibling JJ cord-005453-4057qib7 14500 28 donors donor NNS cord-005453-4057qib7 14500 29 ) ) -RRB- cord-005453-4057qib7 14500 30 is be VBZ cord-005453-4057qib7 14500 31 provided provide VBN cord-005453-4057qib7 14500 32 . . . cord-005453-4057qib7 14501 1 Methods method NNS cord-005453-4057qib7 14501 2 : : : cord-005453-4057qib7 14501 3 In in IN cord-005453-4057qib7 14501 4 this this DT cord-005453-4057qib7 14501 5 retrospective retrospective JJ cord-005453-4057qib7 14501 6 cross cross JJ cord-005453-4057qib7 14501 7 - - JJ cord-005453-4057qib7 14501 8 sectional sectional JJ cord-005453-4057qib7 14501 9 study study NN cord-005453-4057qib7 14501 10 , , , cord-005453-4057qib7 14501 11 a a DT cord-005453-4057qib7 14501 12 two two CD cord-005453-4057qib7 14501 13 - - HYPH cord-005453-4057qib7 14501 14 year year NN cord-005453-4057qib7 14501 15 report report NN cord-005453-4057qib7 14501 16 of of IN cord-005453-4057qib7 14501 17 patients patient NNS cord-005453-4057qib7 14501 18 who who WP cord-005453-4057qib7 14501 19 received receive VBD cord-005453-4057qib7 14501 20 allo allo NN cord-005453-4057qib7 14501 21 - - HYPH cord-005453-4057qib7 14501 22 HSCT HSCT NNP cord-005453-4057qib7 14501 23 from from IN cord-005453-4057qib7 14501 24 their -PRON- PRP$ cord-005453-4057qib7 14501 25 other other JJ cord-005453-4057qib7 14501 26 - - HYPH cord-005453-4057qib7 14501 27 relative relative JJ cord-005453-4057qib7 14501 28 donors donor NNS cord-005453-4057qib7 14501 29 during during IN cord-005453-4057qib7 14501 30 September September NNP cord-005453-4057qib7 14501 31 2016 2016 CD cord-005453-4057qib7 14501 32 to to IN cord-005453-4057qib7 14501 33 September September NNP cord-005453-4057qib7 14501 34 2018 2018 CD cord-005453-4057qib7 14501 35 at at IN cord-005453-4057qib7 14501 36 the the DT cord-005453-4057qib7 14501 37 Department Department NNP cord-005453-4057qib7 14501 38 of of IN cord-005453-4057qib7 14501 39 Stem Stem NNP cord-005453-4057qib7 14501 40 Cell Cell NNP cord-005453-4057qib7 14501 41 transplantation transplantation NN cord-005453-4057qib7 14501 42 of of IN cord-005453-4057qib7 14501 43 Children Children NNP cord-005453-4057qib7 14501 44 's 's POS cord-005453-4057qib7 14501 45 Medical Medical NNP cord-005453-4057qib7 14501 46 Center Center NNP cord-005453-4057qib7 14501 47 in in IN cord-005453-4057qib7 14501 48 Tehran Tehran NNP cord-005453-4057qib7 14501 49 , , , cord-005453-4057qib7 14501 50 Iran Iran NNP cord-005453-4057qib7 14501 51 is be VBZ cord-005453-4057qib7 14501 52 presented present VBN cord-005453-4057qib7 14501 53 . . . cord-005453-4057qib7 14502 1 The the DT cord-005453-4057qib7 14502 2 patients patient NNS cord-005453-4057qib7 14502 3 were be VBD cord-005453-4057qib7 14502 4 followed follow VBN cord-005453-4057qib7 14502 5 up up RP cord-005453-4057qib7 14502 6 until until IN cord-005453-4057qib7 14502 7 1 1 CD cord-005453-4057qib7 14502 8 st st NNP cord-005453-4057qib7 14502 9 December December NNP cord-005453-4057qib7 14502 10 2018 2018 CD cord-005453-4057qib7 14502 11 . . . cord-005453-4057qib7 14503 1 Results result NNS cord-005453-4057qib7 14503 2 : : : cord-005453-4057qib7 14504 1 During during IN cord-005453-4057qib7 14504 2 this this DT cord-005453-4057qib7 14504 3 time time NN cord-005453-4057qib7 14504 4 period period NN cord-005453-4057qib7 14504 5 , , , cord-005453-4057qib7 14504 6 178 178 CD cord-005453-4057qib7 14504 7 patients patient NNS cord-005453-4057qib7 14504 8 underwent undergo VBD cord-005453-4057qib7 14504 9 HSCT HSCT NNP cord-005453-4057qib7 14504 10 ( ( -LRB- cord-005453-4057qib7 14504 11 both both DT cord-005453-4057qib7 14504 12 autologous autologous JJ cord-005453-4057qib7 14504 13 and and CC cord-005453-4057qib7 14504 14 allogeneic allogeneic JJ cord-005453-4057qib7 14504 15 ) ) -RRB- cord-005453-4057qib7 14504 16 at at IN cord-005453-4057qib7 14504 17 this this DT cord-005453-4057qib7 14504 18 center center NN cord-005453-4057qib7 14504 19 , , , cord-005453-4057qib7 14504 20 of of IN cord-005453-4057qib7 14504 21 which which WDT cord-005453-4057qib7 14504 22 159 159 CD cord-005453-4057qib7 14504 23 cases case NNS cord-005453-4057qib7 14504 24 received receive VBD cord-005453-4057qib7 14504 25 allo allo NN cord-005453-4057qib7 14504 26 - - HYPH cord-005453-4057qib7 14504 27 HSCT HSCT NNP cord-005453-4057qib7 14504 28 . . . cord-005453-4057qib7 14505 1 Out out IN cord-005453-4057qib7 14505 2 of of IN cord-005453-4057qib7 14505 3 allo allo NN cord-005453-4057qib7 14505 4 - - HYPH cord-005453-4057qib7 14505 5 HSCT HSCT NNP cord-005453-4057qib7 14505 6 recipients recipient NNS cord-005453-4057qib7 14505 7 , , , cord-005453-4057qib7 14505 8 the the DT cord-005453-4057qib7 14505 9 donors donor NNS cord-005453-4057qib7 14505 10 of of IN cord-005453-4057qib7 14505 11 stem stem NN cord-005453-4057qib7 14505 12 cells cell NNS cord-005453-4057qib7 14505 13 for for IN cord-005453-4057qib7 14505 14 51 51 CD cord-005453-4057qib7 14505 15 cases case NNS cord-005453-4057qib7 14505 16 ( ( -LRB- cord-005453-4057qib7 14505 17 32.1 32.1 CD cord-005453-4057qib7 14505 18 % % NN cord-005453-4057qib7 14505 19 ) ) -RRB- cord-005453-4057qib7 14505 20 were be VBD cord-005453-4057qib7 14505 21 their -PRON- PRP$ cord-005453-4057qib7 14505 22 other other JJ cord-005453-4057qib7 14505 23 - - HYPH cord-005453-4057qib7 14505 24 relatives relative NNS cord-005453-4057qib7 14505 25 . . . cord-005453-4057qib7 14506 1 The the DT cord-005453-4057qib7 14506 2 median median NN cord-005453-4057qib7 14506 3 ( ( -LRB- cord-005453-4057qib7 14506 4 range range NN cord-005453-4057qib7 14506 5 ) ) -RRB- cord-005453-4057qib7 14506 6 age age NN cord-005453-4057qib7 14506 7 at at IN cord-005453-4057qib7 14506 8 HSCT HSCT NNP cord-005453-4057qib7 14506 9 was be VBD cord-005453-4057qib7 14506 10 6 6 CD cord-005453-4057qib7 14506 11 ( ( -LRB- cord-005453-4057qib7 14506 12 1 1 CD cord-005453-4057qib7 14506 13 - - SYM cord-005453-4057qib7 14506 14 11 11 CD cord-005453-4057qib7 14506 15 ) ) -RRB- cord-005453-4057qib7 14506 16 years year NNS cord-005453-4057qib7 14507 1 and and CC cord-005453-4057qib7 14507 2 the the DT cord-005453-4057qib7 14507 3 majority majority NN cord-005453-4057qib7 14507 4 of of IN cord-005453-4057qib7 14507 5 patients patient NNS cord-005453-4057qib7 14507 6 were be VBD cord-005453-4057qib7 14507 7 boys boy NNS cord-005453-4057qib7 14507 8 ( ( -LRB- cord-005453-4057qib7 14507 9 31/51 31/51 CD cord-005453-4057qib7 14507 10 , , , cord-005453-4057qib7 14507 11 60.8 60.8 CD cord-005453-4057qib7 14507 12 % % NN cord-005453-4057qib7 14507 13 ) ) -RRB- cord-005453-4057qib7 14507 14 . . . cord-005453-4057qib7 14508 1 According accord VBG cord-005453-4057qib7 14508 2 to to IN cord-005453-4057qib7 14508 3 disease disease NN cord-005453-4057qib7 14508 4 class class NN cord-005453-4057qib7 14508 5 , , , cord-005453-4057qib7 14508 6 the the DT cord-005453-4057qib7 14508 7 patients patient NNS cord-005453-4057qib7 14508 8 were be VBD cord-005453-4057qib7 14508 9 most most RBS cord-005453-4057qib7 14508 10 commonly commonly RB cord-005453-4057qib7 14508 11 involved involve VBN cord-005453-4057qib7 14508 12 with with IN cord-005453-4057qib7 14508 13 non non JJ cord-005453-4057qib7 14508 14 - - JJ cord-005453-4057qib7 14508 15 malignant malignant JJ cord-005453-4057qib7 14508 16 hematologic hematologic JJ cord-005453-4057qib7 14508 17 diseases disease NNS cord-005453-4057qib7 14508 18 ( ( -LRB- cord-005453-4057qib7 14508 19 18/51 18/51 CD cord-005453-4057qib7 14508 20 patients patient NNS cord-005453-4057qib7 14508 21 , , , cord-005453-4057qib7 14508 22 35.3 35.3 CD cord-005453-4057qib7 14508 23 % % NN cord-005453-4057qib7 14508 24 ) ) -RRB- cord-005453-4057qib7 14509 1 ( ( -LRB- cord-005453-4057qib7 14509 2 Figure figure NN cord-005453-4057qib7 14509 3 ) ) -RRB- cord-005453-4057qib7 14509 4 . . . cord-005453-4057qib7 14510 1 The the DT cord-005453-4057qib7 14510 2 source source NN cord-005453-4057qib7 14510 3 of of IN cord-005453-4057qib7 14510 4 HSCs hscs NN cord-005453-4057qib7 14510 5 for for IN cord-005453-4057qib7 14510 6 most most JJS cord-005453-4057qib7 14510 7 patients patient NNS cord-005453-4057qib7 14510 8 ( ( -LRB- cord-005453-4057qib7 14510 9 48 48 CD cord-005453-4057qib7 14510 10 cases case NNS cord-005453-4057qib7 14510 11 , , , cord-005453-4057qib7 14510 12 94.1 94.1 CD cord-005453-4057qib7 14510 13 % % NN cord-005453-4057qib7 14510 14 ) ) -RRB- cord-005453-4057qib7 14510 15 was be VBD cord-005453-4057qib7 14510 16 peripheral peripheral JJ cord-005453-4057qib7 14510 17 blood blood NN cord-005453-4057qib7 14510 18 and and CC cord-005453-4057qib7 14510 19 for for IN cord-005453-4057qib7 14510 20 only only RB cord-005453-4057qib7 14510 21 3 3 CD cord-005453-4057qib7 14510 22 patients patient NNS cord-005453-4057qib7 14510 23 the the DT cord-005453-4057qib7 14510 24 source source NN cord-005453-4057qib7 14510 25 was be VBD cord-005453-4057qib7 14510 26 bone bone NN cord-005453-4057qib7 14510 27 marrow marrow NN cord-005453-4057qib7 14510 28 . . . cord-005453-4057qib7 14511 1 The the DT cord-005453-4057qib7 14511 2 donors donor NNS cord-005453-4057qib7 14511 3 for for IN cord-005453-4057qib7 14511 4 50 50 CD cord-005453-4057qib7 14511 5 patients patient NNS cord-005453-4057qib7 14511 6 were be VBD cord-005453-4057qib7 14511 7 fully fully RB cord-005453-4057qib7 14511 8 matched match VBN cord-005453-4057qib7 14511 9 and and CC cord-005453-4057qib7 14511 10 only only RB cord-005453-4057qib7 14511 11 one one CD cord-005453-4057qib7 14511 12 patient patient NN cord-005453-4057qib7 14511 13 received receive VBD cord-005453-4057qib7 14511 14 the the DT cord-005453-4057qib7 14511 15 HSCs hscs NN cord-005453-4057qib7 14511 16 from from IN cord-005453-4057qib7 14511 17 a a DT cord-005453-4057qib7 14511 18 one one CD cord-005453-4057qib7 14511 19 - - HYPH cord-005453-4057qib7 14511 20 locus locus NN cord-005453-4057qib7 14511 21 mismatched mismatch VBN cord-005453-4057qib7 14511 22 donor donor NN cord-005453-4057qib7 14511 23 . . . cord-005453-4057qib7 14512 1 HSCT HSCT NNP cord-005453-4057qib7 14512 2 was be VBD cord-005453-4057qib7 14512 3 successful successful JJ cord-005453-4057qib7 14512 4 in in IN cord-005453-4057qib7 14512 5 50 50 CD cord-005453-4057qib7 14512 6 patients patient NNS cord-005453-4057qib7 14512 7 with with IN cord-005453-4057qib7 14512 8 most most JJS cord-005453-4057qib7 14512 9 of of IN cord-005453-4057qib7 14512 10 them -PRON- PRP cord-005453-4057qib7 14512 11 achieving achieve VBG cord-005453-4057qib7 14512 12 full full JJ cord-005453-4057qib7 14512 13 chimerism chimerism NN cord-005453-4057qib7 14512 14 ( ( -LRB- cord-005453-4057qib7 14512 15 44 44 CD cord-005453-4057qib7 14512 16 patients patient NNS cord-005453-4057qib7 14512 17 , , , cord-005453-4057qib7 14512 18 86.2 86.2 CD cord-005453-4057qib7 14512 19 % % NN cord-005453-4057qib7 14512 20 ) ) -RRB- cord-005453-4057qib7 14512 21 followed follow VBN cord-005453-4057qib7 14512 22 by by IN cord-005453-4057qib7 14512 23 those those DT cord-005453-4057qib7 14512 24 developing develop VBG cord-005453-4057qib7 14512 25 mixed mixed JJ cord-005453-4057qib7 14512 26 chimerism chimerism NN cord-005453-4057qib7 14512 27 ( ( -LRB- cord-005453-4057qib7 14513 1 6 6 CD cord-005453-4057qib7 14513 2 patients patient NNS cord-005453-4057qib7 14513 3 , , , cord-005453-4057qib7 14513 4 11.8 11.8 CD cord-005453-4057qib7 14513 5 % % NN cord-005453-4057qib7 14513 6 ) ) -RRB- cord-005453-4057qib7 14513 7 and and CC cord-005453-4057qib7 14513 8 only only RB cord-005453-4057qib7 14513 9 one one CD cord-005453-4057qib7 14513 10 patient patient NN cord-005453-4057qib7 14513 11 ( ( -LRB- cord-005453-4057qib7 14513 12 2 2 CD cord-005453-4057qib7 14513 13 % % NN cord-005453-4057qib7 14513 14 ) ) -RRB- cord-005453-4057qib7 14513 15 experienced experienced JJ cord-005453-4057qib7 14513 16 graft graft NN cord-005453-4057qib7 14513 17 failure failure NN cord-005453-4057qib7 14513 18 . . . cord-005453-4057qib7 14514 1 Post post JJ cord-005453-4057qib7 14514 2 - - JJ cord-005453-4057qib7 14514 3 HSCT hsct JJ cord-005453-4057qib7 14514 4 complications complication NNS cord-005453-4057qib7 14514 5 included include VBD cord-005453-4057qib7 14514 6 CMV CMV NNP cord-005453-4057qib7 14514 7 infection infection NN cord-005453-4057qib7 14514 8 in in IN cord-005453-4057qib7 14514 9 34 34 CD cord-005453-4057qib7 14514 10 patients patient NNS cord-005453-4057qib7 14514 11 ( ( -LRB- cord-005453-4057qib7 14514 12 66.7 66.7 CD cord-005453-4057qib7 14514 13 % % NN cord-005453-4057qib7 14514 14 ) ) -RRB- cord-005453-4057qib7 14514 15 , , , cord-005453-4057qib7 14514 16 other other JJ cord-005453-4057qib7 14514 17 infections infection NNS cord-005453-4057qib7 14514 18 in in IN cord-005453-4057qib7 14514 19 7 7 CD cord-005453-4057qib7 14514 20 ( ( -LRB- cord-005453-4057qib7 14514 21 13.7 13.7 CD cord-005453-4057qib7 14514 22 % % NN cord-005453-4057qib7 14514 23 ) ) -RRB- cord-005453-4057qib7 14514 24 , , , cord-005453-4057qib7 14514 25 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 14514 26 cystitis cystitis NN cord-005453-4057qib7 14514 27 in in IN cord-005453-4057qib7 14514 28 3 3 CD cord-005453-4057qib7 14514 29 ( ( -LRB- cord-005453-4057qib7 14514 30 5.9 5.9 CD cord-005453-4057qib7 14514 31 % % NN cord-005453-4057qib7 14514 32 ) ) -RRB- cord-005453-4057qib7 14514 33 and and CC cord-005453-4057qib7 14514 34 PRES PRES NNP cord-005453-4057qib7 14514 35 in in IN cord-005453-4057qib7 14514 36 2 2 CD cord-005453-4057qib7 14514 37 ( ( -LRB- cord-005453-4057qib7 14514 38 3.9 3.9 CD cord-005453-4057qib7 14514 39 % % NN cord-005453-4057qib7 14514 40 ) ) -RRB- cord-005453-4057qib7 14514 41 . . . cord-005453-4057qib7 14515 1 Acute acute JJ cord-005453-4057qib7 14515 2 GvHD gvhd NN cord-005453-4057qib7 14515 3 occurred occur VBD cord-005453-4057qib7 14515 4 in in IN cord-005453-4057qib7 14515 5 22 22 CD cord-005453-4057qib7 14515 6 patients patient NNS cord-005453-4057qib7 14515 7 ( ( -LRB- cord-005453-4057qib7 14515 8 43.1 43.1 CD cord-005453-4057qib7 14515 9 % % NN cord-005453-4057qib7 14515 10 ) ) -RRB- cord-005453-4057qib7 14515 11 and and CC cord-005453-4057qib7 14515 12 chronic chronic JJ cord-005453-4057qib7 14515 13 GvHD gvhd NN cord-005453-4057qib7 14515 14 in in IN cord-005453-4057qib7 14515 15 3 3 CD cord-005453-4057qib7 14515 16 ( ( -LRB- cord-005453-4057qib7 14515 17 5.9 5.9 CD cord-005453-4057qib7 14515 18 % % NN cord-005453-4057qib7 14515 19 ) ) -RRB- cord-005453-4057qib7 14515 20 . . . cord-005453-4057qib7 14516 1 Death death NN cord-005453-4057qib7 14516 2 occurred occur VBD cord-005453-4057qib7 14516 3 in in IN cord-005453-4057qib7 14516 4 7 7 CD cord-005453-4057qib7 14516 5 cases case NNS cord-005453-4057qib7 14516 6 and and CC cord-005453-4057qib7 14516 7 5 5 CD cord-005453-4057qib7 14516 8 of of IN cord-005453-4057qib7 14516 9 them -PRON- PRP cord-005453-4057qib7 14516 10 were be VBD cord-005453-4057qib7 14516 11 transplant transplant NN cord-005453-4057qib7 14516 12 - - HYPH cord-005453-4057qib7 14516 13 related relate VBN cord-005453-4057qib7 14516 14 , , , cord-005453-4057qib7 14516 15 while while IN cord-005453-4057qib7 14516 16 1 1 CD cord-005453-4057qib7 14516 17 was be VBD cord-005453-4057qib7 14516 18 due due JJ cord-005453-4057qib7 14516 19 to to IN cord-005453-4057qib7 14516 20 disease disease NN cord-005453-4057qib7 14516 21 relapse relapse NN cord-005453-4057qib7 14516 22 and and CC cord-005453-4057qib7 14516 23 1 1 CD cord-005453-4057qib7 14516 24 due due JJ cord-005453-4057qib7 14516 25 to to IN cord-005453-4057qib7 14516 26 graft graft NN cord-005453-4057qib7 14516 27 failure failure NN cord-005453-4057qib7 14516 28 . . . cord-005453-4057qib7 14517 1 The the DT cord-005453-4057qib7 14517 2 median median NN cord-005453-4057qib7 14517 3 of of IN cord-005453-4057qib7 14517 4 overall overall JJ cord-005453-4057qib7 14517 5 survival survival NN cord-005453-4057qib7 14517 6 was be VBD cord-005453-4057qib7 14517 7 469 469 CD cord-005453-4057qib7 14517 8 ( ( -LRB- cord-005453-4057qib7 14517 9 40 40 CD cord-005453-4057qib7 14517 10 - - SYM cord-005453-4057qib7 14517 11 792 792 CD cord-005453-4057qib7 14517 12 ) ) -RRB- cord-005453-4057qib7 14517 13 days day NNS cord-005453-4057qib7 14517 14 . . . cord-005453-4057qib7 14518 1 Conclusions conclusion NNS cord-005453-4057qib7 14518 2 : : : cord-005453-4057qib7 14519 1 The the DT cord-005453-4057qib7 14519 2 likelihood likelihood NN cord-005453-4057qib7 14519 3 of of IN cord-005453-4057qib7 14519 4 receiving receive VBG cord-005453-4057qib7 14519 5 HSCs hscs NN cord-005453-4057qib7 14519 6 from from IN cord-005453-4057qib7 14519 7 an an DT cord-005453-4057qib7 14519 8 HLA HLA NNP cord-005453-4057qib7 14519 9 - - HYPH cord-005453-4057qib7 14519 10 matched match VBN cord-005453-4057qib7 14519 11 other other JJ cord-005453-4057qib7 14519 12 - - HYPH cord-005453-4057qib7 14519 13 relative relative JJ cord-005453-4057qib7 14519 14 donor donor NN cord-005453-4057qib7 14519 15 in in IN cord-005453-4057qib7 14519 16 one one CD cord-005453-4057qib7 14519 17 - - HYPH cord-005453-4057qib7 14519 18 thirds third NNS cord-005453-4057qib7 14519 19 of of IN cord-005453-4057qib7 14519 20 children child NNS cord-005453-4057qib7 14519 21 undergoing undergo VBG cord-005453-4057qib7 14519 22 allo allo NN cord-005453-4057qib7 14519 23 - - HYPH cord-005453-4057qib7 14519 24 HSCT HSCT NNP cord-005453-4057qib7 14519 25 , , , cord-005453-4057qib7 14519 26 with with IN cord-005453-4057qib7 14519 27 comparable comparable JJ cord-005453-4057qib7 14519 28 outcomes outcome NNS cord-005453-4057qib7 14519 29 to to IN cord-005453-4057qib7 14519 30 sibling sibling NN cord-005453-4057qib7 14519 31 and and CC cord-005453-4057qib7 14519 32 unrelated unrelated JJ cord-005453-4057qib7 14519 33 donors donor NNS cord-005453-4057qib7 14519 34 ( ( -LRB- cord-005453-4057qib7 14519 35 as as IN cord-005453-4057qib7 14519 36 evidenced evidence VBN cord-005453-4057qib7 14519 37 in in IN cord-005453-4057qib7 14519 38 this this DT cord-005453-4057qib7 14519 39 study study NN cord-005453-4057qib7 14519 40 compared compare VBN cord-005453-4057qib7 14519 41 with with IN cord-005453-4057qib7 14519 42 other other JJ cord-005453-4057qib7 14519 43 studies study NNS cord-005453-4057qib7 14519 44 ) ) -RRB- cord-005453-4057qib7 14519 45 , , , cord-005453-4057qib7 14519 46 introduces introduce VBZ cord-005453-4057qib7 14519 47 family family NN cord-005453-4057qib7 14519 48 bank bank NN cord-005453-4057qib7 14519 49 as as IN cord-005453-4057qib7 14519 50 a a DT cord-005453-4057qib7 14519 51 reliable reliable JJ cord-005453-4057qib7 14519 52 source source NN cord-005453-4057qib7 14519 53 for for IN cord-005453-4057qib7 14519 54 pediatric pediatric JJ cord-005453-4057qib7 14519 55 allo allo NN cord-005453-4057qib7 14519 56 - - HYPH cord-005453-4057qib7 14519 57 HSCT HSCT NNP cord-005453-4057qib7 14519 58 in in IN cord-005453-4057qib7 14519 59 countries country NNS cord-005453-4057qib7 14519 60 with with IN cord-005453-4057qib7 14519 61 culturally culturally RB cord-005453-4057qib7 14519 62 accepted accept VBN cord-005453-4057qib7 14519 63 cousin cousin NN cord-005453-4057qib7 14519 64 - - HYPH cord-005453-4057qib7 14519 65 cousin cousin NN cord-005453-4057qib7 14519 66 marriages marriage NNS cord-005453-4057qib7 14519 67 . . . cord-005453-4057qib7 14520 1 Hence hence RB cord-005453-4057qib7 14520 2 , , , cord-005453-4057qib7 14520 3 for for IN cord-005453-4057qib7 14520 4 transplant transplant NN cord-005453-4057qib7 14520 5 physicians physician NNS cord-005453-4057qib7 14520 6 , , , cord-005453-4057qib7 14520 7 parental parental JJ cord-005453-4057qib7 14520 8 consanguinity consanguinity NN cord-005453-4057qib7 14520 9 would would MD cord-005453-4057qib7 14520 10 be be VB cord-005453-4057qib7 14520 11 an an DT cord-005453-4057qib7 14520 12 indication indication NN cord-005453-4057qib7 14520 13 of of IN cord-005453-4057qib7 14520 14 an an DT cord-005453-4057qib7 14520 15 extended extended JJ cord-005453-4057qib7 14520 16 search search NN cord-005453-4057qib7 14520 17 for for IN cord-005453-4057qib7 14520 18 a a DT cord-005453-4057qib7 14520 19 potential potential JJ cord-005453-4057qib7 14520 20 matched match VBN cord-005453-4057qib7 14520 21 donor donor NN cord-005453-4057qib7 14520 22 among among IN cord-005453-4057qib7 14520 23 the the DT cord-005453-4057qib7 14520 24 patient patient NN cord-005453-4057qib7 14520 25 's 's POS cord-005453-4057qib7 14520 26 family family NN cord-005453-4057qib7 14520 27 . . . cord-005453-4057qib7 14521 1 [ [ -LRB- cord-005453-4057qib7 14521 2 [ [ -LRB- cord-005453-4057qib7 14521 3 P674 P674 NNP cord-005453-4057qib7 14521 4 Image image NN cord-005453-4057qib7 14521 5 ] ] -RRB- cord-005453-4057qib7 14521 6 1 1 CD cord-005453-4057qib7 14521 7 . . . cord-005453-4057qib7 14522 1 Distribution distribution NN cord-005453-4057qib7 14522 2 of of IN cord-005453-4057qib7 14522 3 patients patient NNS cord-005453-4057qib7 14522 4 according accord VBG cord-005453-4057qib7 14522 5 to to IN cord-005453-4057qib7 14522 6 disease disease NN cord-005453-4057qib7 14522 7 and and CC cord-005453-4057qib7 14522 8 disease disease NN cord-005453-4057qib7 14522 9 class class NN cord-005453-4057qib7 14522 10 ] ] -RRB- cord-005453-4057qib7 14523 1 Disclosure disclosure NN cord-005453-4057qib7 14523 2 : : : cord-005453-4057qib7 14523 3 Nothing nothing NN cord-005453-4057qib7 14523 4 to to TO cord-005453-4057qib7 14523 5 declare declare VB cord-005453-4057qib7 14523 6 . . . cord-005453-4057qib7 14524 1 Abstract Abstract NNP cord-005453-4057qib7 14524 2 already already RB cord-005453-4057qib7 14524 3 published publish VBN cord-005453-4057qib7 14524 4 . . . cord-005453-4057qib7 14525 1 Update update NN cord-005453-4057qib7 14525 2 on on IN cord-005453-4057qib7 14525 3 the the DT cord-005453-4057qib7 14525 4 HLA HLA NNP cord-005453-4057qib7 14525 5 frequency frequency NN cord-005453-4057qib7 14525 6 distribution distribution NN cord-005453-4057qib7 14525 7 of of IN cord-005453-4057qib7 14525 8 the the DT cord-005453-4057qib7 14525 9 portuguese portuguese JJ cord-005453-4057qib7 14525 10 bone bone NN cord-005453-4057qib7 14525 11 marrow marrow NN cord-005453-4057qib7 14525 12 donor donor NN cord-005453-4057qib7 14525 13 registry registry NN cord-005453-4057qib7 14525 14 Eduardo Eduardo NNP cord-005453-4057qib7 14525 15 Espada Espada NNP cord-005453-4057qib7 14525 16 1 1 CD cord-005453-4057qib7 14525 17 , , , cord-005453-4057qib7 14525 18 Dário Dário NNP cord-005453-4057qib7 14525 19 Ligeiro Ligeiro NNP cord-005453-4057qib7 14525 20 2 2 CD cord-005453-4057qib7 14525 21 , , , cord-005453-4057qib7 14525 22 Hélder Hélder NNP cord-005453-4057qib7 14525 23 Trindade Trindade NNP cord-005453-4057qib7 14525 24 2 2 CD cord-005453-4057qib7 14525 25 , , , cord-005453-4057qib7 14525 26 João João NNP cord-005453-4057qib7 14525 27 Forjaz Forjaz NNP cord-005453-4057qib7 14525 28 de de NNP cord-005453-4057qib7 14525 29 Lacerda Lacerda NNP cord-005453-4057qib7 14525 30 1 1 CD cord-005453-4057qib7 14525 31 frequency frequency NN cord-005453-4057qib7 14525 32 distribution distribution NN cord-005453-4057qib7 14525 33 varied vary VBN cord-005453-4057qib7 14525 34 throughout throughout IN cord-005453-4057qib7 14525 35 the the DT cord-005453-4057qib7 14525 36 country country NN cord-005453-4057qib7 14525 37 , , , cord-005453-4057qib7 14525 38 allowing allow VBG cord-005453-4057qib7 14525 39 for for IN cord-005453-4057qib7 14525 40 analyses analysis NNS cord-005453-4057qib7 14525 41 of of IN cord-005453-4057qib7 14525 42 molecular molecular JJ cord-005453-4057qib7 14525 43 variance variance NN cord-005453-4057qib7 14525 44 and and CC cord-005453-4057qib7 14525 45 generation generation NN cord-005453-4057qib7 14525 46 of of IN cord-005453-4057qib7 14525 47 relatively relatively RB cord-005453-4057qib7 14525 48 geographically geographically RB cord-005453-4057qib7 14525 49 accurate accurate JJ cord-005453-4057qib7 14525 50 graphical graphical JJ cord-005453-4057qib7 14525 51 representations representation NNS cord-005453-4057qib7 14525 52 of of IN cord-005453-4057qib7 14525 53 genetic genetic JJ cord-005453-4057qib7 14525 54 distances distance NNS cord-005453-4057qib7 14525 55 between between IN cord-005453-4057qib7 14525 56 regions region NNS cord-005453-4057qib7 14525 57 and and CC cord-005453-4057qib7 14525 58 districts district NNS cord-005453-4057qib7 14525 59 . . . cord-005453-4057qib7 14526 1 Conclusions conclusion NNS cord-005453-4057qib7 14526 2 : : : cord-005453-4057qib7 14527 1 With with IN cord-005453-4057qib7 14527 2 the the DT cord-005453-4057qib7 14527 3 most most RBS cord-005453-4057qib7 14527 4 recent recent JJ cord-005453-4057qib7 14527 5 HLA HLA NNP cord-005453-4057qib7 14527 6 analysis analysis NN cord-005453-4057qib7 14527 7 of of IN cord-005453-4057qib7 14527 8 the the DT cord-005453-4057qib7 14527 9 Portuguese portuguese JJ cord-005453-4057qib7 14527 10 Bone Bone NNP cord-005453-4057qib7 14527 11 Marrow Marrow NNP cord-005453-4057qib7 14527 12 Donor Donor NNP cord-005453-4057qib7 14527 13 Registry Registry NNP cord-005453-4057qib7 14527 14 we -PRON- PRP cord-005453-4057qib7 14527 15 were be VBD cord-005453-4057qib7 14527 16 able able JJ cord-005453-4057qib7 14527 17 to to TO cord-005453-4057qib7 14527 18 extrapolate extrapolate VB cord-005453-4057qib7 14527 19 high high JJ cord-005453-4057qib7 14527 20 - - HYPH cord-005453-4057qib7 14527 21 resolution resolution NN cord-005453-4057qib7 14527 22 haplotype haplotype NN cord-005453-4057qib7 14527 23 frequencies frequency NNS cord-005453-4057qib7 14527 24 from from IN cord-005453-4057qib7 14527 25 the the DT cord-005453-4057qib7 14527 26 most most RBS cord-005453-4057qib7 14527 27 common common JJ cord-005453-4057qib7 14527 28 low low JJ cord-005453-4057qib7 14527 29 - - HYPH cord-005453-4057qib7 14527 30 resolution resolution NN cord-005453-4057qib7 14527 31 HLA HLA NNP cord-005453-4057qib7 14528 1 -A/-B/-DRB1 -A/-B/-DRB1 NNP cord-005453-4057qib7 14528 2 haplotypes haplotype NNS cord-005453-4057qib7 14528 3 ( ( -LRB- cord-005453-4057qib7 14528 4 corresponding correspond VBG cord-005453-4057qib7 14528 5 to to IN cord-005453-4057qib7 14528 6 50 50 CD cord-005453-4057qib7 14528 7 % % NN cord-005453-4057qib7 14528 8 of of IN cord-005453-4057qib7 14528 9 the the DT cord-005453-4057qib7 14528 10 estimated estimate VBN cord-005453-4057qib7 14528 11 haplotypes haplotype NNS cord-005453-4057qib7 14528 12 at at IN cord-005453-4057qib7 14528 13 that that DT cord-005453-4057qib7 14528 14 level level NN cord-005453-4057qib7 14528 15 ) ) -RRB- cord-005453-4057qib7 14528 16 , , , cord-005453-4057qib7 14528 17 which which WDT cord-005453-4057qib7 14528 18 will will MD cord-005453-4057qib7 14528 19 lead lead VB cord-005453-4057qib7 14528 20 to to IN cord-005453-4057qib7 14528 21 an an DT cord-005453-4057qib7 14528 22 optimization optimization NN cord-005453-4057qib7 14528 23 of of IN cord-005453-4057qib7 14528 24 its -PRON- PRP$ cord-005453-4057qib7 14528 25 use use NN cord-005453-4057qib7 14528 26 , , , cord-005453-4057qib7 14528 27 hopefully hopefully RB cord-005453-4057qib7 14528 28 limiting limit VBG cord-005453-4057qib7 14528 29 the the DT cord-005453-4057qib7 14528 30 time time NN cord-005453-4057qib7 14528 31 between between IN cord-005453-4057qib7 14528 32 donor donor NN cord-005453-4057qib7 14528 33 search search NN cord-005453-4057qib7 14528 34 and and CC cord-005453-4057qib7 14528 35 allogeneic allogeneic IN cord-005453-4057qib7 14528 36 hematopoietic hematopoietic JJ cord-005453-4057qib7 14528 37 stem stem NN cord-005453-4057qib7 14528 38 cell cell NN cord-005453-4057qib7 14528 39 transplant transplant NN cord-005453-4057qib7 14528 40 . . . cord-005453-4057qib7 14529 1 Disclosure disclosure NN cord-005453-4057qib7 14529 2 : : : cord-005453-4057qib7 14529 3 Nothing nothing NN cord-005453-4057qib7 14529 4 to to TO cord-005453-4057qib7 14529 5 declare declare VB cord-005453-4057qib7 14529 6 . . . cord-005453-4057qib7 14530 1 Abstract Abstract NNP cord-005453-4057qib7 14530 2 already already RB cord-005453-4057qib7 14530 3 published publish VBN cord-005453-4057qib7 14530 4 . . . cord-005453-4057qib7 14531 1 Abstract Abstract NNP cord-005453-4057qib7 14531 2 already already RB cord-005453-4057qib7 14531 3 published publish VBN cord-005453-4057qib7 14531 4 . . . cord-005453-4057qib7 14532 1 Unmanipulated unmanipulated JJ cord-005453-4057qib7 14532 2 haploidentical haploidentical JJ cord-005453-4057qib7 14532 3 donor donor NN cord-005453-4057qib7 14532 4 transplantation transplantation NN cord-005453-4057qib7 14532 5 compared compare VBN cord-005453-4057qib7 14532 6 to to IN cord-005453-4057qib7 14532 7 identical identical JJ cord-005453-4057qib7 14532 8 sibling sibling NN cord-005453-4057qib7 14532 9 donor donor NN cord-005453-4057qib7 14532 10 had have VBD cord-005453-4057qib7 14532 11 better well JJR cord-005453-4057qib7 14532 12 antileukemia antileukemia NN cord-005453-4057qib7 14532 13 effect effect NN cord-005453-4057qib7 14532 14 for for IN cord-005453-4057qib7 14532 15 refractory refractory JJ cord-005453-4057qib7 14532 16 / / SYM cord-005453-4057qib7 14532 17 relapsed relapse VBD cord-005453-4057qib7 14532 18 acute acute JJ cord-005453-4057qib7 14532 19 myeloid myeloid NN cord-005453-4057qib7 14532 20 leukemia leukemia NN cord-005453-4057qib7 14532 21 in in IN cord-005453-4057qib7 14532 22 not not RB cord-005453-4057qib7 14532 23 remission remission NN cord-005453-4057qib7 14532 24 status status NN cord-005453-4057qib7 14532 25 Background background NN cord-005453-4057qib7 14532 26 : : : cord-005453-4057qib7 14533 1 Patients patient NNS cord-005453-4057qib7 14533 2 diagnosed diagnose VBN cord-005453-4057qib7 14533 3 with with IN cord-005453-4057qib7 14533 4 SAA SAA NNP cord-005453-4057qib7 14533 5 with with IN cord-005453-4057qib7 14533 6 no no DT cord-005453-4057qib7 14533 7 sibling sibling NN cord-005453-4057qib7 14533 8 donors donor NNS cord-005453-4057qib7 14533 9 and and CC cord-005453-4057qib7 14533 10 who who WP cord-005453-4057qib7 14533 11 are be VBP cord-005453-4057qib7 14533 12 refractory refractory JJ cord-005453-4057qib7 14533 13 to to IN cord-005453-4057qib7 14533 14 immunosupression immunosupression NN cord-005453-4057qib7 14534 1 are be VBP cord-005453-4057qib7 14534 2 candidates candidate NNS cord-005453-4057qib7 14534 3 to to IN cord-005453-4057qib7 14534 4 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 14534 5 Stem Stem NNP cord-005453-4057qib7 14534 6 Cell Cell NNP cord-005453-4057qib7 14534 7 Transplant transplant NN cord-005453-4057qib7 14534 8 using use VBG cord-005453-4057qib7 14534 9 alternative alternative JJ cord-005453-4057qib7 14534 10 donors donor NNS cord-005453-4057qib7 14534 11 . . . cord-005453-4057qib7 14535 1 Haploidentical haploidentical JJ cord-005453-4057qib7 14535 2 donor donor NN cord-005453-4057qib7 14535 3 transplants transplant NNS cord-005453-4057qib7 14535 4 has have VBZ cord-005453-4057qib7 14535 5 been be VBN cord-005453-4057qib7 14535 6 reported report VBN cord-005453-4057qib7 14535 7 using use VBG cord-005453-4057qib7 14535 8 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 14535 9 ( ( -LRB- cord-005453-4057qib7 14535 10 Cy Cy NNP cord-005453-4057qib7 14535 11 ) ) -RRB- cord-005453-4057qib7 14535 12 post post JJ cord-005453-4057qib7 14535 13 stem stem NN cord-005453-4057qib7 14535 14 cell cell NN cord-005453-4057qib7 14535 15 infusion infusion NN cord-005453-4057qib7 14535 16 as as IN cord-005453-4057qib7 14535 17 immunephrophylaxis immunephrophylaxis NNP cord-005453-4057qib7 14535 18 . . . cord-005453-4057qib7 14536 1 The the DT cord-005453-4057qib7 14536 2 present present JJ cord-005453-4057qib7 14536 3 study study NN cord-005453-4057qib7 14536 4 has have VBZ cord-005453-4057qib7 14536 5 the the DT cord-005453-4057qib7 14536 6 objective objective NN cord-005453-4057qib7 14536 7 of of IN cord-005453-4057qib7 14536 8 evaluating evaluate VBG cord-005453-4057qib7 14536 9 overall overall JJ cord-005453-4057qib7 14536 10 survival survival NN cord-005453-4057qib7 14536 11 and and CC cord-005453-4057qib7 14536 12 engraftment engraftment NN cord-005453-4057qib7 14536 13 rates rate NNS cord-005453-4057qib7 14536 14 after after IN cord-005453-4057qib7 14536 15 Haploidentical Haploidentical NNP cord-005453-4057qib7 14536 16 stem stem NN cord-005453-4057qib7 14536 17 cell cell NN cord-005453-4057qib7 14536 18 transplant transplant NN cord-005453-4057qib7 14536 19 for for IN cord-005453-4057qib7 14536 20 SAA SAA NNP cord-005453-4057qib7 14536 21 in in IN cord-005453-4057qib7 14536 22 a a DT cord-005453-4057qib7 14536 23 reference reference NN cord-005453-4057qib7 14536 24 center center NN cord-005453-4057qib7 14536 25 . . . cord-005453-4057qib7 14537 1 Methods method NNS cord-005453-4057qib7 14537 2 : : : cord-005453-4057qib7 14537 3 15 15 CD cord-005453-4057qib7 14537 4 SAA SAA NNP cord-005453-4057qib7 14537 5 adult adult NN cord-005453-4057qib7 14537 6 patients patient NNS cord-005453-4057qib7 14537 7 ( ( -LRB- cord-005453-4057qib7 14537 8 ≥15 ≥15 NNP cord-005453-4057qib7 14537 9 yo yo NNP cord-005453-4057qib7 14537 10 ) ) -RRB- cord-005453-4057qib7 14537 11 received receive VBD cord-005453-4057qib7 14537 12 HSCT HSCT NNP cord-005453-4057qib7 14537 13 from from IN cord-005453-4057qib7 14537 14 haploidentical haploidentical JJ cord-005453-4057qib7 14537 15 donors donor NNS cord-005453-4057qib7 14537 16 from from IN cord-005453-4057qib7 14537 17 de de NNP cord-005453-4057qib7 14537 18 January/2010 January/2010 NNP cord-005453-4057qib7 14538 1 to to IN cord-005453-4057qib7 14538 2 August/2018 August/2018 NNP cord-005453-4057qib7 14538 3 . . . cord-005453-4057qib7 14539 1 Median median JJ cord-005453-4057qib7 14539 2 age age NN cord-005453-4057qib7 14539 3 was be VBD cord-005453-4057qib7 14539 4 19 19 CD cord-005453-4057qib7 14539 5 y y NN cord-005453-4057qib7 14539 6 ( ( -LRB- cord-005453-4057qib7 14539 7 15 15 CD cord-005453-4057qib7 14539 8 - - SYM cord-005453-4057qib7 14539 9 28 28 CD cord-005453-4057qib7 14539 10 ) ) -RRB- cord-005453-4057qib7 14539 11 ; ; : cord-005453-4057qib7 14539 12 Donor Donor NNP cord-005453-4057qib7 14539 13 was be VBD cord-005453-4057qib7 14539 14 the the DT cord-005453-4057qib7 14539 15 father father NN cord-005453-4057qib7 14539 16 in in IN cord-005453-4057qib7 14539 17 six six CD cord-005453-4057qib7 14539 18 , , , cord-005453-4057qib7 14539 19 mother mother NN cord-005453-4057qib7 14539 20 in in IN cord-005453-4057qib7 14539 21 five five CD cord-005453-4057qib7 14539 22 and and CC cord-005453-4057qib7 14539 23 a a DT cord-005453-4057qib7 14539 24 brother brother NN cord-005453-4057qib7 14539 25 in in IN cord-005453-4057qib7 14539 26 four four CD cord-005453-4057qib7 14539 27 cases case NNS cord-005453-4057qib7 14539 28 . . . cord-005453-4057qib7 14540 1 Stem stem JJ cord-005453-4057qib7 14540 2 cell cell NN cord-005453-4057qib7 14540 3 source source NN cord-005453-4057qib7 14540 4 was be VBD cord-005453-4057qib7 14540 5 marrow marrow NN cord-005453-4057qib7 14540 6 in in IN cord-005453-4057qib7 14540 7 13 13 CD cord-005453-4057qib7 14540 8 cases case NNS cord-005453-4057qib7 14540 9 ( ( -LRB- cord-005453-4057qib7 14540 10 87 87 CD cord-005453-4057qib7 14540 11 % % NN cord-005453-4057qib7 14540 12 ) ) -RRB- cord-005453-4057qib7 14540 13 . . . cord-005453-4057qib7 14541 1 Conditioning conditioning NN cord-005453-4057qib7 14541 2 : : : cord-005453-4057qib7 14541 3 10 10 CD cord-005453-4057qib7 14541 4 patients patient NNS cord-005453-4057qib7 14541 5 ( ( -LRB- cord-005453-4057qib7 14541 6 67 67 CD cord-005453-4057qib7 14541 7 % % NN cord-005453-4057qib7 14541 8 ) ) -RRB- cord-005453-4057qib7 14541 9 received receive VBD cord-005453-4057qib7 14541 10 Cy Cy NNP cord-005453-4057qib7 14541 11 29mg 29mg NNP cord-005453-4057qib7 14541 12 / / SYM cord-005453-4057qib7 14541 13 kg kg NN cord-005453-4057qib7 14541 14 , , , cord-005453-4057qib7 14541 15 fludarabine fludarabine NNP cord-005453-4057qib7 14541 16 30mg 30mg NNP cord-005453-4057qib7 14541 17 / / SYM cord-005453-4057qib7 14541 18 m² m² NNP cord-005453-4057qib7 14541 19 e e NNP cord-005453-4057qib7 14541 20 TBI TBI NNP cord-005453-4057qib7 14541 21 200cGy 200cgy NN cord-005453-4057qib7 14541 22 . . . cord-005453-4057qib7 14542 1 The the DT cord-005453-4057qib7 14542 2 remaining remain VBG cord-005453-4057qib7 14542 3 received receive VBD cord-005453-4057qib7 14542 4 the the DT cord-005453-4057qib7 14542 5 same same JJ cord-005453-4057qib7 14542 6 drugs drug NNS cord-005453-4057qib7 14542 7 but but CC cord-005453-4057qib7 14542 8 radiotherapy radiotherapy NN cord-005453-4057qib7 14542 9 dose dose NN cord-005453-4057qib7 14542 10 varied varied JJ cord-005453-4057qib7 14542 11 from from IN cord-005453-4057qib7 14542 12 300 300 CD cord-005453-4057qib7 14542 13 - - HYPH cord-005453-4057qib7 14542 14 400cGy 400cgy CD cord-005453-4057qib7 14542 15 , , , cord-005453-4057qib7 14542 16 All all DT cord-005453-4057qib7 14542 17 them -PRON- PRP cord-005453-4057qib7 14542 18 received receive VBD cord-005453-4057qib7 14542 19 immunephrophylaxis immunephrophylaxis JJ cord-005453-4057qib7 14542 20 with with IN cord-005453-4057qib7 14542 21 post post NN cord-005453-4057qib7 14542 22 transplant transplant NN cord-005453-4057qib7 14542 23 CY CY NNP cord-005453-4057qib7 14542 24 100mg 100mg NNP cord-005453-4057qib7 14542 25 / / SYM cord-005453-4057qib7 14542 26 Kg Kg NNP cord-005453-4057qib7 14542 27 , , , cord-005453-4057qib7 14542 28 cyclosporine cyclosporine NN cord-005453-4057qib7 14542 29 and and CC cord-005453-4057qib7 14542 30 MMF mmf NN cord-005453-4057qib7 14542 31 . . . cord-005453-4057qib7 14543 1 Median median NN cord-005453-4057qib7 14543 2 of of IN cord-005453-4057qib7 14543 3 infused infuse VBN cord-005453-4057qib7 14543 4 cells cell NNS cord-005453-4057qib7 14543 5 ( ( -LRB- cord-005453-4057qib7 14543 6 TCN TCN NNP cord-005453-4057qib7 14543 7 ) ) -RRB- cord-005453-4057qib7 14543 8 was be VBD cord-005453-4057qib7 14543 9 4,94x10 4,94x10 CD cord-005453-4057qib7 14543 10 8 8 CD cord-005453-4057qib7 14544 1 /kg /kg . cord-005453-4057qib7 14545 1 ( ( -LRB- cord-005453-4057qib7 14545 2 2,07 2,07 CD cord-005453-4057qib7 14545 3 - - SYM cord-005453-4057qib7 14545 4 12,66 12,66 CD cord-005453-4057qib7 14545 5 ) ) -RRB- cord-005453-4057qib7 14545 6 . . . cord-005453-4057qib7 14546 1 Results result NNS cord-005453-4057qib7 14546 2 : : : cord-005453-4057qib7 14547 1 eight eight CD cord-005453-4057qib7 14547 2 patients patient NNS cord-005453-4057qib7 14547 3 engrafted engraft VBN cord-005453-4057qib7 14547 4 ( ( -LRB- cord-005453-4057qib7 14547 5 53 53 CD cord-005453-4057qib7 14547 6 % % NN cord-005453-4057qib7 14547 7 ) ) -RRB- cord-005453-4057qib7 14547 8 . . . cord-005453-4057qib7 14548 1 Among among IN cord-005453-4057qib7 14548 2 seven seven CD cord-005453-4057qib7 14548 3 graft graft NN cord-005453-4057qib7 14548 4 failures failure NNS cord-005453-4057qib7 14548 5 four four CD cord-005453-4057qib7 14548 6 received receive VBD cord-005453-4057qib7 14548 7 a a DT cord-005453-4057qib7 14548 8 second second JJ cord-005453-4057qib7 14548 9 haploidentical haploidentical JJ cord-005453-4057qib7 14548 10 transplant transplant NN cord-005453-4057qib7 14548 11 and and CC cord-005453-4057qib7 14548 12 one one CD cord-005453-4057qib7 14548 13 received receive VBD cord-005453-4057qib7 14548 14 an an DT cord-005453-4057qib7 14548 15 unrelated unrelated JJ cord-005453-4057qib7 14548 16 donor donor NN cord-005453-4057qib7 14548 17 transplant transplant NN cord-005453-4057qib7 14548 18 as as IN cord-005453-4057qib7 14548 19 salvage salvage NN cord-005453-4057qib7 14548 20 regimen regimen NN cord-005453-4057qib7 14548 21 . . . cord-005453-4057qib7 14549 1 Two two CD cord-005453-4057qib7 14549 2 patients patient NNS cord-005453-4057qib7 14549 3 were be VBD cord-005453-4057qib7 14549 4 successfully successfully RB cord-005453-4057qib7 14549 5 rescued rescue VBN cord-005453-4057qib7 14549 6 after after IN cord-005453-4057qib7 14549 7 the the DT cord-005453-4057qib7 14549 8 second second JJ cord-005453-4057qib7 14549 9 haplo haplo NN cord-005453-4057qib7 14549 10 and and CC cord-005453-4057qib7 14549 11 the the DT cord-005453-4057qib7 14549 12 others other NNS cord-005453-4057qib7 14549 13 died die VBD cord-005453-4057qib7 14549 14 from from IN cord-005453-4057qib7 14549 15 infectious infectious JJ cord-005453-4057qib7 14549 16 complications complication NNS cord-005453-4057qib7 14549 17 . . . cord-005453-4057qib7 14550 1 Three three CD cord-005453-4057qib7 14550 2 years year NNS cord-005453-4057qib7 14550 3 overall overall JJ cord-005453-4057qib7 14550 4 survival survival NN cord-005453-4057qib7 14550 5 was be VBD cord-005453-4057qib7 14550 6 55 55 CD cord-005453-4057qib7 14550 7 % % NN cord-005453-4057qib7 14550 8 . . . cord-005453-4057qib7 14551 1 Death death NN cord-005453-4057qib7 14551 2 causes cause NNS cord-005453-4057qib7 14551 3 included include VBN cord-005453-4057qib7 14551 4 : : : cord-005453-4057qib7 14551 5 five five CD cord-005453-4057qib7 14551 6 infections infection NNS cord-005453-4057qib7 14551 7 and and CC cord-005453-4057qib7 14551 8 two two CD cord-005453-4057qib7 14551 9 lung lung NN cord-005453-4057qib7 14551 10 hemorrhage hemorrhage NN cord-005453-4057qib7 14551 11 . . . cord-005453-4057qib7 14552 1 Median median JJ cord-005453-4057qib7 14552 2 survival survival NN cord-005453-4057qib7 14552 3 was be VBD cord-005453-4057qib7 14552 4 93 93 CD cord-005453-4057qib7 14552 5 days day NNS cord-005453-4057qib7 14552 6 ( ( -LRB- cord-005453-4057qib7 14552 7 17 17 CD cord-005453-4057qib7 14552 8 - - SYM cord-005453-4057qib7 14552 9 1065 1065 CD cord-005453-4057qib7 14552 10 ) ) -RRB- cord-005453-4057qib7 14552 11 . . . cord-005453-4057qib7 14553 1 No no DT cord-005453-4057qib7 14553 2 patient patient NN cord-005453-4057qib7 14553 3 had have VBD cord-005453-4057qib7 14553 4 acute acute JJ cord-005453-4057qib7 14553 5 graft graft NN cord-005453-4057qib7 14553 6 - - HYPH cord-005453-4057qib7 14553 7 versus versus IN cord-005453-4057qib7 14553 8 - - HYPH cord-005453-4057qib7 14553 9 host host NN cord-005453-4057qib7 14553 10 - - HYPH cord-005453-4057qib7 14553 11 disease disease NN cord-005453-4057qib7 14553 12 ( ( -LRB- cord-005453-4057qib7 14553 13 GVHD GVHD NNP cord-005453-4057qib7 14553 14 ) ) -RRB- cord-005453-4057qib7 14553 15 and and CC cord-005453-4057qib7 14554 1 one one CD cord-005453-4057qib7 14554 2 patient patient NN cord-005453-4057qib7 14554 3 had have VBD cord-005453-4057qib7 14554 4 mild mild JJ cord-005453-4057qib7 14554 5 c c NN cord-005453-4057qib7 14554 6 - - HYPH cord-005453-4057qib7 14554 7 GVHD GVHD NNP cord-005453-4057qib7 14554 8 . . . cord-005453-4057qib7 14555 1 Conclusions conclusion NNS cord-005453-4057qib7 14555 2 : : : cord-005453-4057qib7 14556 1 Haploidentical haploidentical JJ cord-005453-4057qib7 14556 2 transplant transplant NN cord-005453-4057qib7 14556 3 was be VBD cord-005453-4057qib7 14556 4 feasible feasible JJ cord-005453-4057qib7 14556 5 as as IN cord-005453-4057qib7 14556 6 therapy therapy NN cord-005453-4057qib7 14556 7 for for IN cord-005453-4057qib7 14556 8 SAA SAA NNP cord-005453-4057qib7 14556 9 refractory refractory JJ cord-005453-4057qib7 14556 10 to to IN cord-005453-4057qib7 14556 11 immunessupression immunessupression NN cord-005453-4057qib7 14556 12 with with IN cord-005453-4057qib7 14556 13 an an DT cord-005453-4057qib7 14556 14 overall overall JJ cord-005453-4057qib7 14556 15 survival survival NN cord-005453-4057qib7 14556 16 of of IN cord-005453-4057qib7 14556 17 55 55 CD cord-005453-4057qib7 14556 18 % % NN cord-005453-4057qib7 14556 19 in in IN cord-005453-4057qib7 14556 20 this this DT cord-005453-4057qib7 14556 21 cohort cohort NN cord-005453-4057qib7 14556 22 . . . cord-005453-4057qib7 14557 1 Graft graft NN cord-005453-4057qib7 14557 2 failure failure NN cord-005453-4057qib7 14557 3 however however RB cord-005453-4057qib7 14557 4 is be VBZ cord-005453-4057qib7 14557 5 still still RB cord-005453-4057qib7 14557 6 a a DT cord-005453-4057qib7 14557 7 problem problem NN cord-005453-4057qib7 14557 8 to to TO cord-005453-4057qib7 14557 9 be be VB cord-005453-4057qib7 14557 10 addressed address VBN cord-005453-4057qib7 14557 11 in in IN cord-005453-4057qib7 14557 12 this this DT cord-005453-4057qib7 14557 13 setting setting NN cord-005453-4057qib7 14557 14 . . . cord-005453-4057qib7 14558 1 Disclosure disclosure NN cord-005453-4057qib7 14558 2 : : : cord-005453-4057qib7 14558 3 no no DT cord-005453-4057qib7 14558 4 disclosure disclosure NN cord-005453-4057qib7 14558 5 Stem Stem NNP cord-005453-4057qib7 14558 6 cell cell NN cord-005453-4057qib7 14558 7 mobilization mobilization NN cord-005453-4057qib7 14558 8 , , , cord-005453-4057qib7 14558 9 collection collection NN cord-005453-4057qib7 14558 10 and and CC cord-005453-4057qib7 14558 11 engineering engineering NN cord-005453-4057qib7 14558 12 P681 P681 NNP cord-005453-4057qib7 14558 13 Abstract Abstract NNP cord-005453-4057qib7 14558 14 already already RB cord-005453-4057qib7 14558 15 published publish VBN cord-005453-4057qib7 14558 16 . . . cord-005453-4057qib7 14559 1 Key key JJ cord-005453-4057qib7 14559 2 performance performance NN cord-005453-4057qib7 14559 3 and and CC cord-005453-4057qib7 14559 4 quality quality NN cord-005453-4057qib7 14559 5 indicators indicator NNS cord-005453-4057qib7 14559 6 for for IN cord-005453-4057qib7 14559 7 a a DT cord-005453-4057qib7 14559 8 successful successful JJ cord-005453-4057qib7 14559 9 bone bone NN cord-005453-4057qib7 14559 10 marrow marrow NN cord-005453-4057qib7 14559 11 collection collection NN cord-005453-4057qib7 14559 12 Marco Marco NNP cord-005453-4057qib7 14559 13 Sampaio Sampaio NNP cord-005453-4057qib7 14559 14 1,2 1,2 CD cord-005453-4057qib7 14559 15 , , , cord-005453-4057qib7 14559 16 Ana Ana NNP cord-005453-4057qib7 14559 17 Salselas Salselas NNP cord-005453-4057qib7 14559 18 2 2 CD cord-005453-4057qib7 14559 19 , , , cord-005453-4057qib7 14559 20 Fátima Fátima NNP cord-005453-4057qib7 14559 21 Amado Amado NNP cord-005453-4057qib7 14559 22 2 2 CD cord-005453-4057qib7 14559 23 , , , cord-005453-4057qib7 14559 24 Filipa Filipa NNP cord-005453-4057qib7 14559 25 Bordalo Bordalo NNP cord-005453-4057qib7 14559 26 2 2 CD cord-005453-4057qib7 14559 27 , , , cord-005453-4057qib7 14559 28 Sérgio Sérgio NNP cord-005453-4057qib7 14559 29 Lopes Lopes NNP cord-005453-4057qib7 14559 30 2 2 CD cord-005453-4057qib7 14559 31 , , , cord-005453-4057qib7 14559 32 Catarina Catarina NNP cord-005453-4057qib7 14559 33 Pinho Pinho NNP cord-005453-4057qib7 14559 34 2 2 CD cord-005453-4057qib7 14559 35 , , , cord-005453-4057qib7 14559 36 Susana Susana NNP cord-005453-4057qib7 14559 37 Roncon Roncon NNP cord-005453-4057qib7 14559 38 2 2 CD cord-005453-4057qib7 14559 39 and and CC cord-005453-4057qib7 14559 40 one one CD cord-005453-4057qib7 14559 41 from from IN cord-005453-4057qib7 14559 42 ECC ECC NNP cord-005453-4057qib7 14559 43 ( ( -LRB- cord-005453-4057qib7 14560 1 Staphylococcus staphylococcus NN cord-005453-4057qib7 14560 2 spp.)presented spp.)presente VBD cord-005453-4057qib7 14560 3 positive positive JJ cord-005453-4057qib7 14560 4 microbiological microbiological JJ cord-005453-4057qib7 14560 5 results result NNS cord-005453-4057qib7 14560 6 . . . cord-005453-4057qib7 14561 1 Conclusions conclusion NNS cord-005453-4057qib7 14561 2 : : : cord-005453-4057qib7 14561 3 BM BM NNP cord-005453-4057qib7 14561 4 collection collection NN cord-005453-4057qib7 14561 5 is be VBZ cord-005453-4057qib7 14561 6 a a DT cord-005453-4057qib7 14561 7 challenging challenging JJ cord-005453-4057qib7 14561 8 strategy strategy NN cord-005453-4057qib7 14561 9 because because IN cord-005453-4057qib7 14561 10 it -PRON- PRP cord-005453-4057qib7 14561 11 is be VBZ cord-005453-4057qib7 14561 12 a a DT cord-005453-4057qib7 14561 13 one one CD cord-005453-4057qib7 14561 14 - - HYPH cord-005453-4057qib7 14561 15 time time NN cord-005453-4057qib7 14561 16 procedure procedure NN cord-005453-4057qib7 14561 17 and and CC cord-005453-4057qib7 14561 18 manually manually RB cord-005453-4057qib7 14561 19 operatordependent operatordependent JJ cord-005453-4057qib7 14561 20 technique technique NN cord-005453-4057qib7 14561 21 ; ; : cord-005453-4057qib7 14561 22 simultaneously simultaneously RB cord-005453-4057qib7 14561 23 it -PRON- PRP cord-005453-4057qib7 14561 24 is be VBZ cord-005453-4057qib7 14561 25 more more RBR cord-005453-4057qib7 14561 26 difficult difficult JJ cord-005453-4057qib7 14561 27 to to TO cord-005453-4057qib7 14561 28 control control VB cord-005453-4057qib7 14561 29 the the DT cord-005453-4057qib7 14561 30 final final JJ cord-005453-4057qib7 14561 31 cellular cellular JJ cord-005453-4057qib7 14561 32 content content NN cord-005453-4057qib7 14561 33 of of IN cord-005453-4057qib7 14561 34 the the DT cord-005453-4057qib7 14561 35 BM BM NNP cord-005453-4057qib7 14561 36 , , , cord-005453-4057qib7 14561 37 which which WDT cord-005453-4057qib7 14561 38 is be VBZ cord-005453-4057qib7 14561 39 a a DT cord-005453-4057qib7 14561 40 risk risk NN cord-005453-4057qib7 14561 41 for for IN cord-005453-4057qib7 14561 42 donor donor NN cord-005453-4057qib7 14561 43 volume volume NN cord-005453-4057qib7 14561 44 depletion depletion NN cord-005453-4057qib7 14561 45 . . . cord-005453-4057qib7 14562 1 BM BM NNP cord-005453-4057qib7 14562 2 collection collection NN cord-005453-4057qib7 14562 3 is be VBZ cord-005453-4057qib7 14562 4 feasible feasible JJ cord-005453-4057qib7 14562 5 even even RB cord-005453-4057qib7 14562 6 with with IN cord-005453-4057qib7 14562 7 donor donor NN cord-005453-4057qib7 14562 8 and and CC cord-005453-4057qib7 14562 9 recipient recipient NN cord-005453-4057qib7 14562 10 weight weight NN cord-005453-4057qib7 14562 11 difference difference NN cord-005453-4057qib7 14562 12 . . . cord-005453-4057qib7 14563 1 Poorer poor JJR cord-005453-4057qib7 14563 2 performance performance NN cord-005453-4057qib7 14563 3 may may MD cord-005453-4057qib7 14563 4 be be VB cord-005453-4057qib7 14563 5 found find VBN cord-005453-4057qib7 14563 6 when when WRB cord-005453-4057qib7 14563 7 higher high JJR cord-005453-4057qib7 14563 8 TNC TNC NNP cord-005453-4057qib7 14563 9 are be VBP cord-005453-4057qib7 14563 10 requested request VBN cord-005453-4057qib7 14563 11 . . . cord-005453-4057qib7 14564 1 We -PRON- PRP cord-005453-4057qib7 14564 2 respond respond VBP cord-005453-4057qib7 14564 3 efficaciously efficaciously RB cord-005453-4057qib7 14564 4 when when WRB cord-005453-4057qib7 14564 5 the the DT cord-005453-4057qib7 14564 6 request request NN cord-005453-4057qib7 14564 7 is be VBZ cord-005453-4057qib7 14564 8 between between IN cord-005453-4057qib7 14564 9 200 200 CD cord-005453-4057qib7 14564 10 and and CC cord-005453-4057qib7 14564 11 400 400 CD cord-005453-4057qib7 14564 12 * * NFP cord-005453-4057qib7 14564 13 10 10 CD cord-005453-4057qib7 14564 14 8 8 CD cord-005453-4057qib7 14564 15 TNC TNC NNP cord-005453-4057qib7 14565 1 but but CC cord-005453-4057qib7 14565 2 we -PRON- PRP cord-005453-4057qib7 14565 3 fail fail VBP cord-005453-4057qib7 14565 4 to to TO cord-005453-4057qib7 14565 5 accomplish accomplish VB cord-005453-4057qib7 14565 6 higher high JJR cord-005453-4057qib7 14565 7 TNC TNC NNP cord-005453-4057qib7 14565 8 values value NNS cord-005453-4057qib7 14565 9 . . . cord-005453-4057qib7 14566 1 We -PRON- PRP cord-005453-4057qib7 14566 2 must must MD cord-005453-4057qib7 14566 3 emphasise emphasise VB cord-005453-4057qib7 14566 4 that that IN cord-005453-4057qib7 14566 5 ICC ICC NNP cord-005453-4057qib7 14566 6 TNC TNC NNP cord-005453-4057qib7 14566 7 demanded demand VBD cord-005453-4057qib7 14566 8 was be VBD cord-005453-4057qib7 14566 9 generally generally RB cord-005453-4057qib7 14566 10 lower low JJR cord-005453-4057qib7 14566 11 than than IN cord-005453-4057qib7 14566 12 ECC ECC NNP cord-005453-4057qib7 14566 13 . . . cord-005453-4057qib7 14567 1 Deciding decide VBG cord-005453-4057qib7 14567 2 the the DT cord-005453-4057qib7 14567 3 appropriate appropriate JJ cord-005453-4057qib7 14567 4 TNC TNC NNP cord-005453-4057qib7 14567 5 for for IN cord-005453-4057qib7 14567 6 each each DT cord-005453-4057qib7 14567 7 patient patient NN cord-005453-4057qib7 14567 8 remains remain VBZ cord-005453-4057qib7 14567 9 a a DT cord-005453-4057qib7 14567 10 dare dare NN cord-005453-4057qib7 14567 11 and and CC cord-005453-4057qib7 14567 12 an an DT cord-005453-4057qib7 14567 13 art art NN cord-005453-4057qib7 14567 14 . . . cord-005453-4057qib7 14568 1 Disclosure disclosure NN cord-005453-4057qib7 14568 2 : : : cord-005453-4057qib7 14568 3 Nothing nothing NN cord-005453-4057qib7 14568 4 to to TO cord-005453-4057qib7 14568 5 declare declare VB cord-005453-4057qib7 14568 6 . . . cord-005453-4057qib7 14569 1 Impact impact NN cord-005453-4057qib7 14569 2 of of IN cord-005453-4057qib7 14569 3 adding add VBG cord-005453-4057qib7 14569 4 plerixafor plerixafor NN cord-005453-4057qib7 14569 5 to to IN cord-005453-4057qib7 14569 6 mobilization mobilization NN cord-005453-4057qib7 14569 7 protocol protocol NN cord-005453-4057qib7 14569 8 in in IN cord-005453-4057qib7 14569 9 the the DT cord-005453-4057qib7 14569 10 immune immune JJ cord-005453-4057qib7 14569 11 reconstitution reconstitution NN cord-005453-4057qib7 14569 12 of of IN cord-005453-4057qib7 14569 13 VδT VδT NNP cord-005453-4057qib7 14569 14 cells cell NNS cord-005453-4057qib7 14569 15 after after IN cord-005453-4057qib7 14569 16 autologous autologous JJ cord-005453-4057qib7 14569 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 14569 18 stem stem NN cord-005453-4057qib7 14569 19 cell cell NN cord-005453-4057qib7 14569 20 transplantation transplantation NN cord-005453-4057qib7 14569 21 Efrat Efrat NNP cord-005453-4057qib7 14569 22 Luttwak Luttwak NNP cord-005453-4057qib7 14569 23 1,2 1,2 CD cord-005453-4057qib7 14569 24 , , , cord-005453-4057qib7 14569 25 Yael Yael NNP cord-005453-4057qib7 14569 26 Chava Chava NNP cord-005453-4057qib7 14569 27 Cohen Cohen NNP cord-005453-4057qib7 14569 28 1,2 1,2 CD cord-005453-4057qib7 14569 29 , , , cord-005453-4057qib7 14569 30 Odelia Odelia NNP cord-005453-4057qib7 14569 31 Amit Amit NNP cord-005453-4057qib7 14569 32 1,2 1,2 CD cord-005453-4057qib7 14569 33 , , , cord-005453-4057qib7 14569 34 Irit Irit NNP cord-005453-4057qib7 14569 35 Avivi Avivi NNP cord-005453-4057qib7 14569 36 1,2 1,2 CD cord-005453-4057qib7 14569 37 , , , cord-005453-4057qib7 14569 38 Svetlana Svetlana NNP cord-005453-4057qib7 14569 39 Trestman Trestman NNP cord-005453-4057qib7 14569 40 1,2 1,2 CD cord-005453-4057qib7 14569 41 , , , cord-005453-4057qib7 14569 42 Esti Esti NNP cord-005453-4057qib7 14569 43 Rom Rom NNP cord-005453-4057qib7 14569 44 1,2 1,2 NNP cord-005453-4057qib7 14569 45 , , , cord-005453-4057qib7 14569 46 Rinat Rinat NNP cord-005453-4057qib7 14569 47 Eshel Eshel NNP cord-005453-4057qib7 14569 48 1,2 1,2 CD cord-005453-4057qib7 14569 49 , , , cord-005453-4057qib7 14569 50 Ram Ram NNP cord-005453-4057qib7 14569 51 Ron Ron NNP cord-005453-4057qib7 14569 52 1,2 1,2 CD cord-005453-4057qib7 14569 53 1 1 CD cord-005453-4057qib7 14569 54 Tel Tel NNP cord-005453-4057qib7 14569 55 Aviv Aviv NNP cord-005453-4057qib7 14569 56 Medical Medical NNP cord-005453-4057qib7 14569 57 Center Center NNP cord-005453-4057qib7 14569 58 , , , cord-005453-4057qib7 14569 59 Tel Tel NNP cord-005453-4057qib7 14569 60 Aviv Aviv NNP cord-005453-4057qib7 14569 61 , , , cord-005453-4057qib7 14569 62 Israel Israel NNP cord-005453-4057qib7 14569 63 , , , cord-005453-4057qib7 14569 64 2 2 CD cord-005453-4057qib7 14569 65 Sackler Sackler NNP cord-005453-4057qib7 14569 66 Faculty Faculty NNP cord-005453-4057qib7 14569 67 of of IN cord-005453-4057qib7 14569 68 Medicine Medicine NNP cord-005453-4057qib7 14569 69 , , , cord-005453-4057qib7 14569 70 Tel Tel NNP cord-005453-4057qib7 14569 71 Aviv Aviv NNP cord-005453-4057qib7 14569 72 University University NNP cord-005453-4057qib7 14569 73 , , , cord-005453-4057qib7 14569 74 Tel Tel NNP cord-005453-4057qib7 14569 75 Aviv Aviv NNP cord-005453-4057qib7 14570 1 , , , cord-005453-4057qib7 14570 2 Israel Israel NNP cord-005453-4057qib7 14570 3 Background Background NNP cord-005453-4057qib7 14570 4 : : : cord-005453-4057qib7 14571 1 Multiple multiple JJ cord-005453-4057qib7 14571 2 Myeloma Myeloma NNP cord-005453-4057qib7 14571 3 has have VBZ cord-005453-4057qib7 14571 4 remained remain VBN cord-005453-4057qib7 14571 5 an an DT cord-005453-4057qib7 14571 6 incurable incurable JJ cord-005453-4057qib7 14571 7 disease disease NN cord-005453-4057qib7 14571 8 even even RB cord-005453-4057qib7 14571 9 in in IN cord-005453-4057qib7 14571 10 the the DT cord-005453-4057qib7 14571 11 era era NN cord-005453-4057qib7 14571 12 of of IN cord-005453-4057qib7 14571 13 novel novel JJ cord-005453-4057qib7 14571 14 therapies therapy NNS cord-005453-4057qib7 14571 15 . . . cord-005453-4057qib7 14572 1 Front front JJ cord-005453-4057qib7 14572 2 line line NN cord-005453-4057qib7 14572 3 treatment treatment NN cord-005453-4057qib7 14572 4 typically typically RB cord-005453-4057qib7 14572 5 comprises comprise VBZ cord-005453-4057qib7 14572 6 of of IN cord-005453-4057qib7 14572 7 induction induction NN cord-005453-4057qib7 14572 8 chemotherapy chemotherapy NN cord-005453-4057qib7 14572 9 with with IN cord-005453-4057qib7 14572 10 4 4 CD cord-005453-4057qib7 14572 11 - - SYM cord-005453-4057qib7 14572 12 6 6 CD cord-005453-4057qib7 14572 13 cycles cycle NNS cord-005453-4057qib7 14572 14 of of IN cord-005453-4057qib7 14572 15 a a DT cord-005453-4057qib7 14572 16 bortezomib bortezomib NN cord-005453-4057qib7 14572 17 - - HYPH cord-005453-4057qib7 14572 18 based base VBN cord-005453-4057qib7 14572 19 regimen regimen NN cord-005453-4057qib7 14572 20 , , , cord-005453-4057qib7 14572 21 stem stem NN cord-005453-4057qib7 14572 22 cell cell NN cord-005453-4057qib7 14572 23 mobilization mobilization NN cord-005453-4057qib7 14572 24 , , , cord-005453-4057qib7 14572 25 and and CC cord-005453-4057qib7 14572 26 harvesting harvesting NN cord-005453-4057qib7 14572 27 of of IN cord-005453-4057qib7 14572 28 peripheral peripheral JJ cord-005453-4057qib7 14572 29 blood blood NN cord-005453-4057qib7 14572 30 stem stem NN cord-005453-4057qib7 14572 31 cells cell NNS cord-005453-4057qib7 14572 32 ( ( -LRB- cord-005453-4057qib7 14572 33 PBSC PBSC NNP cord-005453-4057qib7 14572 34 ) ) -RRB- cord-005453-4057qib7 14572 35 by by IN cord-005453-4057qib7 14572 36 apharesis apharesis NNP cord-005453-4057qib7 14572 37 , , , cord-005453-4057qib7 14572 38 followed follow VBN cord-005453-4057qib7 14572 39 by by IN cord-005453-4057qib7 14572 40 high high JJ cord-005453-4057qib7 14572 41 dose dose NN cord-005453-4057qib7 14572 42 melphalan melphalan NN cord-005453-4057qib7 14572 43 with with IN cord-005453-4057qib7 14572 44 HCT HCT NNP cord-005453-4057qib7 14572 45 . . . cord-005453-4057qib7 14573 1 While while IN cord-005453-4057qib7 14573 2 brotezomib brotezomib NN cord-005453-4057qib7 14573 3 - - HYPH cord-005453-4057qib7 14573 4 based base VBN cord-005453-4057qib7 14573 5 induction induction NN cord-005453-4057qib7 14573 6 regimens regimen NNS cord-005453-4057qib7 14573 7 have have VBP cord-005453-4057qib7 14573 8 demonstrated demonstrate VBN cord-005453-4057qib7 14573 9 no no DT cord-005453-4057qib7 14573 10 adverse adverse JJ cord-005453-4057qib7 14573 11 impact impact NN cord-005453-4057qib7 14573 12 on on IN cord-005453-4057qib7 14573 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 14573 14 cell cell NN cord-005453-4057qib7 14573 15 harvest harvest NN cord-005453-4057qib7 14573 16 number number NN cord-005453-4057qib7 14573 17 and and CC cord-005453-4057qib7 14573 18 quality quality NN cord-005453-4057qib7 14573 19 , , , cord-005453-4057qib7 14573 20 no no DT cord-005453-4057qib7 14573 21 study study NN cord-005453-4057qib7 14573 22 analyzed analyze VBD cord-005453-4057qib7 14573 23 the the DT cord-005453-4057qib7 14573 24 impact impact NN cord-005453-4057qib7 14573 25 of of IN cord-005453-4057qib7 14573 26 timing timing NN cord-005453-4057qib7 14573 27 of of IN cord-005453-4057qib7 14573 28 the the DT cord-005453-4057qib7 14573 29 last last JJ cord-005453-4057qib7 14573 30 brotezomib brotezomib NNP cord-005453-4057qib7 14573 31 dose dose NN cord-005453-4057qib7 14573 32 prior prior RB cord-005453-4057qib7 14573 33 to to IN cord-005453-4057qib7 14573 34 collection collection NN cord-005453-4057qib7 14573 35 . . . cord-005453-4057qib7 14574 1 In in IN cord-005453-4057qib7 14574 2 this this DT cord-005453-4057qib7 14574 3 study study NN cord-005453-4057qib7 14574 4 we -PRON- PRP cord-005453-4057qib7 14574 5 aimed aim VBD cord-005453-4057qib7 14574 6 to to TO cord-005453-4057qib7 14574 7 determine determine VB cord-005453-4057qib7 14574 8 the the DT cord-005453-4057qib7 14574 9 effect effect NN cord-005453-4057qib7 14574 10 of of IN cord-005453-4057qib7 14574 11 the the DT cord-005453-4057qib7 14574 12 timing timing NN cord-005453-4057qib7 14574 13 of of IN cord-005453-4057qib7 14574 14 the the DT cord-005453-4057qib7 14574 15 last last JJ cord-005453-4057qib7 14574 16 dose dose NN cord-005453-4057qib7 14574 17 of of IN cord-005453-4057qib7 14574 18 brotezomib brotezomib NNP cord-005453-4057qib7 14574 19 before before IN cord-005453-4057qib7 14574 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 14574 21 cell cell NN cord-005453-4057qib7 14574 22 collection collection NN cord-005453-4057qib7 14574 23 and and CC cord-005453-4057qib7 14574 24 the the DT cord-005453-4057qib7 14574 25 collection collection NN cord-005453-4057qib7 14574 26 yield yield NN cord-005453-4057qib7 14574 27 . . . cord-005453-4057qib7 14575 1 Methods method NNS cord-005453-4057qib7 14575 2 : : : cord-005453-4057qib7 14575 3 This this DT cord-005453-4057qib7 14575 4 was be VBD cord-005453-4057qib7 14575 5 a a DT cord-005453-4057qib7 14575 6 single single JJ cord-005453-4057qib7 14575 7 center center NN cord-005453-4057qib7 14575 8 historical historical JJ cord-005453-4057qib7 14575 9 prospective prospective JJ cord-005453-4057qib7 14575 10 study study NN cord-005453-4057qib7 14575 11 , , , cord-005453-4057qib7 14575 12 including include VBG cord-005453-4057qib7 14575 13 all all DT cord-005453-4057qib7 14575 14 sequential sequential JJ cord-005453-4057qib7 14575 15 newly newly RB cord-005453-4057qib7 14575 16 diagnosed diagnose VBN cord-005453-4057qib7 14575 17 patients patient NNS cord-005453-4057qib7 14575 18 with with IN cord-005453-4057qib7 14575 19 myeloma myeloma NN cord-005453-4057qib7 14575 20 between between IN cord-005453-4057qib7 14575 21 2012 2012 CD cord-005453-4057qib7 14575 22 and and CC cord-005453-4057qib7 14575 23 2017 2017 CD cord-005453-4057qib7 14575 24 that that WDT cord-005453-4057qib7 14575 25 were be VBD cord-005453-4057qib7 14575 26 given give VBN cord-005453-4057qib7 14575 27 a a DT cord-005453-4057qib7 14575 28 bortezomib bortezomib NN cord-005453-4057qib7 14575 29 - - HYPH cord-005453-4057qib7 14575 30 based base VBN cord-005453-4057qib7 14575 31 induction induction NN cord-005453-4057qib7 14575 32 therapy therapy NN cord-005453-4057qib7 14575 33 ( ( -LRB- cord-005453-4057qib7 14575 34 ≤6 ≤6 NNS cord-005453-4057qib7 14575 35 cycles cycle NNS cord-005453-4057qib7 14575 36 ) ) -RRB- cord-005453-4057qib7 14575 37 followed follow VBN cord-005453-4057qib7 14575 38 by by IN cord-005453-4057qib7 14575 39 PBSC PBSC NNP cord-005453-4057qib7 14575 40 collection collection NN cord-005453-4057qib7 14575 41 . . . cord-005453-4057qib7 14576 1 We -PRON- PRP cord-005453-4057qib7 14576 2 excluded exclude VBD cord-005453-4057qib7 14576 3 patients patient NNS cord-005453-4057qib7 14576 4 who who WP cord-005453-4057qib7 14576 5 either either CC cord-005453-4057qib7 14576 6 received receive VBD cord-005453-4057qib7 14576 7 1 1 CD cord-005453-4057qib7 14576 8 st st NNP cord-005453-4057qib7 14576 9 line line NN cord-005453-4057qib7 14576 10 VTD VTD NNP cord-005453-4057qib7 14576 11 - - HYPH cord-005453-4057qib7 14576 12 PACE pace NN cord-005453-4057qib7 14576 13 or or CC cord-005453-4057qib7 14576 14 lenalidomide lenalidomide NN cord-005453-4057qib7 14576 15 - - HYPH cord-005453-4057qib7 14576 16 containing contain VBG cord-005453-4057qib7 14576 17 regimens regimen NNS cord-005453-4057qib7 14576 18 . . . cord-005453-4057qib7 14577 1 Peripheral peripheral JJ cord-005453-4057qib7 14577 2 blood blood NN cord-005453-4057qib7 14577 3 CD34 CD34 NNP cord-005453-4057qib7 14578 1 + + CC cord-005453-4057qib7 14578 2 cells cell NNS cord-005453-4057qib7 14578 3 were be VBD cord-005453-4057qib7 14578 4 measured measure VBN cord-005453-4057qib7 14578 5 on on IN cord-005453-4057qib7 14578 6 the the DT cord-005453-4057qib7 14578 7 day day NN cord-005453-4057qib7 14578 8 of of IN cord-005453-4057qib7 14578 9 collection collection NN cord-005453-4057qib7 14578 10 . . . cord-005453-4057qib7 14579 1 Patients patient NNS cord-005453-4057qib7 14579 2 with with IN cord-005453-4057qib7 14579 3 CD34 CD34 NNP cord-005453-4057qib7 14579 4 + + CC cord-005453-4057qib7 14579 5 levels level NNS cord-005453-4057qib7 14579 6 of of IN cord-005453-4057qib7 14579 7 > > SYM cord-005453-4057qib7 14579 8 10 10 CD cord-005453-4057qib7 14579 9 cells/ cells/ CD cord-005453-4057qib7 14579 10 microliter microliter NN cord-005453-4057qib7 14579 11 started start VBD cord-005453-4057qib7 14579 12 collection collection NN cord-005453-4057qib7 14579 13 on on IN cord-005453-4057qib7 14579 14 the the DT cord-005453-4057qib7 14579 15 same same JJ cord-005453-4057qib7 14579 16 day day NN cord-005453-4057qib7 14579 17 , , , cord-005453-4057qib7 14579 18 while while IN cord-005453-4057qib7 14579 19 those those DT cord-005453-4057qib7 14579 20 with with IN cord-005453-4057qib7 14579 21 lower low JJR cord-005453-4057qib7 14579 22 levels level NNS cord-005453-4057qib7 14579 23 were be VBD cord-005453-4057qib7 14579 24 given give VBN cord-005453-4057qib7 14579 25 plerixafor plerixafor NN cord-005453-4057qib7 14579 26 . . . cord-005453-4057qib7 14580 1 We -PRON- PRP cord-005453-4057qib7 14580 2 performed perform VBD cord-005453-4057qib7 14580 3 regression regression NN cord-005453-4057qib7 14580 4 analyses analysis NNS cord-005453-4057qib7 14580 5 to to TO cord-005453-4057qib7 14580 6 analyze analyze VB cord-005453-4057qib7 14580 7 the the DT cord-005453-4057qib7 14580 8 impact impact NN cord-005453-4057qib7 14580 9 of of IN cord-005453-4057qib7 14580 10 a a DT cord-005453-4057qib7 14580 11 variety variety NN cord-005453-4057qib7 14580 12 of of IN cord-005453-4057qib7 14580 13 precollection precollection NN cord-005453-4057qib7 14580 14 factors factor NNS cord-005453-4057qib7 14580 15 , , , cord-005453-4057qib7 14580 16 including include VBG cord-005453-4057qib7 14580 17 days day NNS cord-005453-4057qib7 14580 18 from from IN cord-005453-4057qib7 14580 19 last last JJ cord-005453-4057qib7 14580 20 bortezomib bortezomib NN cord-005453-4057qib7 14580 21 therapy therapy NN cord-005453-4057qib7 14580 22 on on IN cord-005453-4057qib7 14580 23 the the DT cord-005453-4057qib7 14580 24 collection collection NN cord-005453-4057qib7 14580 25 yield yield NN cord-005453-4057qib7 14580 26 . . . cord-005453-4057qib7 14581 1 Results result NNS cord-005453-4057qib7 14581 2 : : : cord-005453-4057qib7 14582 1 We -PRON- PRP cord-005453-4057qib7 14582 2 identified identify VBD cord-005453-4057qib7 14582 3 75 75 CD cord-005453-4057qib7 14582 4 patients patient NNS cord-005453-4057qib7 14582 5 who who WP cord-005453-4057qib7 14582 6 fulfilled fulfil VBD cord-005453-4057qib7 14582 7 the the DT cord-005453-4057qib7 14582 8 inclusion inclusion NN cord-005453-4057qib7 14582 9 criteria criterion NNS cord-005453-4057qib7 14582 10 , , , cord-005453-4057qib7 14582 11 Table table NN cord-005453-4057qib7 14582 12 . . . cord-005453-4057qib7 14583 1 Median median JJ cord-005453-4057qib7 14583 2 time time NN cord-005453-4057qib7 14583 3 from from IN cord-005453-4057qib7 14583 4 last last JJ cord-005453-4057qib7 14583 5 dose dose NN cord-005453-4057qib7 14583 6 of of IN cord-005453-4057qib7 14583 7 brotezomib brotezomib NNP cord-005453-4057qib7 14583 8 to to IN cord-005453-4057qib7 14583 9 first first JJ cord-005453-4057qib7 14583 10 leukapheresis leukapheresis NN cord-005453-4057qib7 14583 11 was be VBD cord-005453-4057qib7 14583 12 11 11 CD cord-005453-4057qib7 14584 1 ( ( -LRB- cord-005453-4057qib7 14584 2 range range NN cord-005453-4057qib7 14584 3 , , , cord-005453-4057qib7 14584 4 2 2 CD cord-005453-4057qib7 14584 5 - - SYM cord-005453-4057qib7 14584 6 27 27 CD cord-005453-4057qib7 14584 7 ) ) -RRB- cord-005453-4057qib7 14584 8 days day NNS cord-005453-4057qib7 14584 9 . . . cord-005453-4057qib7 14585 1 A a DT cord-005453-4057qib7 14585 2 statistically statistically RB cord-005453-4057qib7 14585 3 significant significant JJ cord-005453-4057qib7 14585 4 correlation correlation NN cord-005453-4057qib7 14585 5 was be VBD cord-005453-4057qib7 14585 6 found find VBN cord-005453-4057qib7 14585 7 between between IN cord-005453-4057qib7 14585 8 the the DT cord-005453-4057qib7 14585 9 days day NNS cord-005453-4057qib7 14585 10 from from IN cord-005453-4057qib7 14585 11 last last JJ cord-005453-4057qib7 14585 12 dose dose NN cord-005453-4057qib7 14585 13 of of IN cord-005453-4057qib7 14585 14 brotezomib brotezomib NN cord-005453-4057qib7 14585 15 and and CC cord-005453-4057qib7 14585 16 both both CC cord-005453-4057qib7 14585 17 the the DT cord-005453-4057qib7 14585 18 first first JJ cord-005453-4057qib7 14585 19 collection collection NN cord-005453-4057qib7 14585 20 day day NN cord-005453-4057qib7 14585 21 - - HYPH cord-005453-4057qib7 14585 22 CD34 CD34 NNP cord-005453-4057qib7 14585 23 + + CC cord-005453-4057qib7 14585 24 cells cell NNS cord-005453-4057qib7 14585 25 / / SYM cord-005453-4057qib7 14585 26 kg kg NN cord-005453-4057qib7 14585 27 ( ( -LRB- cord-005453-4057qib7 14585 28 r=0.466 r=0.466 NNP cord-005453-4057qib7 14585 29 , , , cord-005453-4057qib7 14585 30 P p NN cord-005453-4057qib7 14585 31 < < XX cord-005453-4057qib7 14585 32 0.001 0.001 CD cord-005453-4057qib7 14585 33 ) ) -RRB- cord-005453-4057qib7 14585 34 , , , cord-005453-4057qib7 14585 35 and and CC cord-005453-4057qib7 14585 36 the the DT cord-005453-4057qib7 14585 37 total total NN cord-005453-4057qib7 14585 38 collected collect VBN cord-005453-4057qib7 14585 39 CD34 CD34 NNP cord-005453-4057qib7 14586 1 + + CC cord-005453-4057qib7 14586 2 cells cell NNS cord-005453-4057qib7 14586 3 / / SYM cord-005453-4057qib7 14586 4 kg(r=0.341 kg(r=0.341 NN cord-005453-4057qib7 14586 5 , , , cord-005453-4057qib7 14586 6 P=0.03 P=0.03 NNP cord-005453-4057qib7 14586 7 ) ) -RRB- cord-005453-4057qib7 14586 8 , , , cord-005453-4057qib7 14586 9 Figure figure NN cord-005453-4057qib7 14586 10 . . . cord-005453-4057qib7 14587 1 The the DT cord-005453-4057qib7 14587 2 optimal optimal JJ cord-005453-4057qib7 14587 3 cutoff cutoff NN cord-005453-4057qib7 14587 4 point point NN cord-005453-4057qib7 14587 5 as as IN cord-005453-4057qib7 14587 6 indicated indicate VBN cord-005453-4057qib7 14587 7 by by IN cord-005453-4057qib7 14587 8 the the DT cord-005453-4057qib7 14587 9 ROC ROC NNP cord-005453-4057qib7 14587 10 curve curve NN cord-005453-4057qib7 14587 11 was be VBD cord-005453-4057qib7 14587 12 8.5 8.5 CD cord-005453-4057qib7 14587 13 days day NNS cord-005453-4057qib7 14587 14 according accord VBG cord-005453-4057qib7 14587 15 to to IN cord-005453-4057qib7 14587 16 collection collection NN cord-005453-4057qib7 14587 17 success success NN cord-005453-4057qib7 14587 18 with with IN cord-005453-4057qib7 14587 19 sensitivity sensitivity NN cord-005453-4057qib7 14587 20 of of IN cord-005453-4057qib7 14587 21 79 79 CD cord-005453-4057qib7 14587 22 % % NN cord-005453-4057qib7 14587 23 and and CC cord-005453-4057qib7 14587 24 specificity specificity NN cord-005453-4057qib7 14587 25 of of IN cord-005453-4057qib7 14587 26 74 74 CD cord-005453-4057qib7 14587 27 % % NN cord-005453-4057qib7 14587 28 , , , cord-005453-4057qib7 14587 29 Youden´s Youden´s NNPS cord-005453-4057qib7 14587 30 index index NN cord-005453-4057qib7 14587 31 0.52 0.52 CD cord-005453-4057qib7 14587 32 . . . cord-005453-4057qib7 14588 1 In in IN cord-005453-4057qib7 14588 2 multivariate multivariate JJ cord-005453-4057qib7 14588 3 analysis analysis NN cord-005453-4057qib7 14588 4 included include VBD cord-005453-4057qib7 14588 5 other other JJ cord-005453-4057qib7 14588 6 factors factor NNS cord-005453-4057qib7 14588 7 affecting affect VBG cord-005453-4057qib7 14588 8 collection collection NN cord-005453-4057qib7 14588 9 yield yield NN cord-005453-4057qib7 14588 10 ( ( -LRB- cord-005453-4057qib7 14588 11 age age NN cord-005453-4057qib7 14588 12 , , , cord-005453-4057qib7 14588 13 gender gender NN cord-005453-4057qib7 14588 14 , , , cord-005453-4057qib7 14588 15 status status NN cord-005453-4057qib7 14588 16 of of IN cord-005453-4057qib7 14588 17 disease disease NN cord-005453-4057qib7 14588 18 at at IN cord-005453-4057qib7 14588 19 collection collection NN cord-005453-4057qib7 14588 20 , , , cord-005453-4057qib7 14588 21 and and CC cord-005453-4057qib7 14588 22 prior prior JJ cord-005453-4057qib7 14588 23 radiation radiation NN cord-005453-4057qib7 14588 24 ) ) -RRB- cord-005453-4057qib7 14589 1 -timing -timing : cord-005453-4057qib7 14589 2 of of IN cord-005453-4057qib7 14589 3 last last JJ cord-005453-4057qib7 14589 4 dose dose NN cord-005453-4057qib7 14589 5 of of IN cord-005453-4057qib7 14589 6 brotizomib brotizomib NN cord-005453-4057qib7 14589 7 remained remain VBD cord-005453-4057qib7 14589 8 significantly significantly RB cord-005453-4057qib7 14589 9 associated associate VBN cord-005453-4057qib7 14589 10 with with IN cord-005453-4057qib7 14589 11 the the DT cord-005453-4057qib7 14589 12 total total NN cord-005453-4057qib7 14589 13 collected collect VBN cord-005453-4057qib7 14589 14 CD34 CD34 NNP cord-005453-4057qib7 14589 15 + + CC cord-005453-4057qib7 14589 16 cells cell NNS cord-005453-4057qib7 14589 17 / / SYM cord-005453-4057qib7 14589 18 kg kg NN cord-005453-4057qib7 14589 19 ( ( -LRB- cord-005453-4057qib7 14589 20 p=0.01 p=0.01 NNP cord-005453-4057qib7 14589 21 ) ) -RRB- cord-005453-4057qib7 14589 22 . . . cord-005453-4057qib7 14590 1 Increasing increase VBG cord-005453-4057qib7 14590 2 age age NN cord-005453-4057qib7 14590 3 , , , cord-005453-4057qib7 14590 4 female female JJ cord-005453-4057qib7 14590 5 gender gender NN cord-005453-4057qib7 14590 6 , , , cord-005453-4057qib7 14590 7 and and CC cord-005453-4057qib7 14590 8 prior prior JJ cord-005453-4057qib7 14590 9 radiation radiation NN cord-005453-4057qib7 14590 10 were be VBD cord-005453-4057qib7 14590 11 associated associate VBN cord-005453-4057qib7 14590 12 with with IN cord-005453-4057qib7 14590 13 lower low JJR cord-005453-4057qib7 14590 14 collection collection NN cord-005453-4057qib7 14590 15 yield yield NN cord-005453-4057qib7 14590 16 ( ( -LRB- cord-005453-4057qib7 14590 17 p=0.006 p=0.006 NNS cord-005453-4057qib7 14590 18 , , , cord-005453-4057qib7 14590 19 0.012 0.012 CD cord-005453-4057qib7 14590 20 , , , cord-005453-4057qib7 14590 21 0.043 0.043 CD cord-005453-4057qib7 14590 22 , , , cord-005453-4057qib7 14590 23 respectively respectively RB cord-005453-4057qib7 14590 24 ) ) -RRB- cord-005453-4057qib7 14590 25 . . . cord-005453-4057qib7 14591 1 Based base VBN cord-005453-4057qib7 14591 2 on on IN cord-005453-4057qib7 14591 3 this this DT cord-005453-4057qib7 14591 4 , , , cord-005453-4057qib7 14591 5 we -PRON- PRP cord-005453-4057qib7 14591 6 developed develop VBD cord-005453-4057qib7 14591 7 a a DT cord-005453-4057qib7 14591 8 model model NN cord-005453-4057qib7 14591 9 to to TO cord-005453-4057qib7 14591 10 predict predict VB cord-005453-4057qib7 14591 11 the the DT cord-005453-4057qib7 14591 12 total total NN cord-005453-4057qib7 14591 13 collected collect VBN cord-005453-4057qib7 14591 14 CD34pos cd34pos NN cord-005453-4057qib7 14591 15 cells cell NNS cord-005453-4057qib7 14591 16 = = NFP cord-005453-4057qib7 14592 1 11.76 11.76 CD cord-005453-4057qib7 14592 2 + + CD cord-005453-4057qib7 14592 3 0.13 0.13 CD cord-005453-4057qib7 14593 1 ( ( -LRB- cord-005453-4057qib7 14593 2 timing timing NN cord-005453-4057qib7 14593 3 in in IN cord-005453-4057qib7 14593 4 days day NNS cord-005453-4057qib7 14593 5 of of IN cord-005453-4057qib7 14593 6 last last JJ cord-005453-4057qib7 14593 7 dose dose NN cord-005453-4057qib7 14593 8 of of IN cord-005453-4057qib7 14593 9 brotezomib brotezomib JJ cord-005453-4057qib7 14593 10 ) ) -RRB- cord-005453-4057qib7 14593 11 -0.1 -0.1 . cord-005453-4057qib7 14593 12 ( ( -LRB- cord-005453-4057qib7 14593 13 age age NN cord-005453-4057qib7 14593 14 ) ) -RRB- cord-005453-4057qib7 14594 1 -1.39 -1.39 CD cord-005453-4057qib7 14595 1 ( ( -LRB- cord-005453-4057qib7 14595 2 if if IN cord-005453-4057qib7 14595 3 female female JJ cord-005453-4057qib7 14595 4 ) ) -RRB- cord-005453-4057qib7 14595 5 -0.01 -0.01 CD cord-005453-4057qib7 14596 1 ( ( -LRB- cord-005453-4057qib7 14596 2 ≥PR ≥pr NN cord-005453-4057qib7 14596 3 ) ) -RRB- cord-005453-4057qib7 14597 1 -1.35 -1.35 : cord-005453-4057qib7 14598 1 ( ( -LRB- cord-005453-4057qib7 14598 2 if if IN cord-005453-4057qib7 14598 3 prior prior JJ cord-005453-4057qib7 14598 4 radation radation NN cord-005453-4057qib7 14598 5 ) ) -RRB- cord-005453-4057qib7 14598 6 . . . cord-005453-4057qib7 14599 1 Conclusions conclusion NNS cord-005453-4057qib7 14599 2 : : : cord-005453-4057qib7 14600 1 Timing timing NN cord-005453-4057qib7 14600 2 of of IN cord-005453-4057qib7 14600 3 last last JJ cord-005453-4057qib7 14600 4 dose dose NN cord-005453-4057qib7 14600 5 of of IN cord-005453-4057qib7 14600 6 brotezomib brotezomib NNP cord-005453-4057qib7 14600 7 is be VBZ cord-005453-4057qib7 14600 8 an an DT cord-005453-4057qib7 14600 9 important important JJ cord-005453-4057qib7 14600 10 factor factor NN cord-005453-4057qib7 14600 11 for for IN cord-005453-4057qib7 14600 12 predicting predict VBG cord-005453-4057qib7 14600 13 a a DT cord-005453-4057qib7 14600 14 successful successful JJ cord-005453-4057qib7 14600 15 collection collection NN cord-005453-4057qib7 14600 16 . . . cord-005453-4057qib7 14601 1 A a DT cord-005453-4057qib7 14601 2 washout washout NN cord-005453-4057qib7 14601 3 period period NN cord-005453-4057qib7 14601 4 of of IN cord-005453-4057qib7 14601 5 9 9 CD cord-005453-4057qib7 14601 6 days day NNS cord-005453-4057qib7 14601 7 is be VBZ cord-005453-4057qib7 14601 8 associated associate VBN cord-005453-4057qib7 14601 9 with with IN cord-005453-4057qib7 14601 10 a a DT cord-005453-4057qib7 14601 11 better well JJR cord-005453-4057qib7 14601 12 collection collection NN cord-005453-4057qib7 14601 13 yield yield NN cord-005453-4057qib7 14601 14 . . . cord-005453-4057qib7 14602 1 These these DT cord-005453-4057qib7 14602 2 results result NNS cord-005453-4057qib7 14602 3 should should MD cord-005453-4057qib7 14602 4 be be VB cord-005453-4057qib7 14602 5 further further RB cord-005453-4057qib7 14602 6 validated validate VBN cord-005453-4057qib7 14602 7 in in IN cord-005453-4057qib7 14602 8 a a DT cord-005453-4057qib7 14602 9 prospective prospective JJ cord-005453-4057qib7 14602 10 study study NN cord-005453-4057qib7 14602 11 . . . cord-005453-4057qib7 14603 1 Age age NN cord-005453-4057qib7 14603 2 ( ( -LRB- cord-005453-4057qib7 14603 3 median median NN cord-005453-4057qib7 14603 4 , , , cord-005453-4057qib7 14603 5 range range NN cord-005453-4057qib7 14603 6 ) ) -RRB- cord-005453-4057qib7 14603 7 63 63 CD cord-005453-4057qib7 14603 8 ( ( -LRB- cord-005453-4057qib7 14603 9 37 37 CD cord-005453-4057qib7 14603 10 - - SYM cord-005453-4057qib7 14603 11 78 78 CD cord-005453-4057qib7 14603 12 ) ) -RRB- cord-005453-4057qib7 14604 1 Gender gender NN cord-005453-4057qib7 14604 2 -male -male NN cord-005453-4057qib7 14604 3 ( ( -LRB- cord-005453-4057qib7 14604 4 % % NN cord-005453-4057qib7 14604 5 ) ) -RRB- cord-005453-4057qib7 14604 6 44 44 CD cord-005453-4057qib7 14604 7 ( ( -LRB- cord-005453-4057qib7 14604 8 59 59 CD cord-005453-4057qib7 14604 9 ) ) -RRB- cord-005453-4057qib7 14605 1 Prior prior JJ cord-005453-4057qib7 14605 2 radiation radiation NN cord-005453-4057qib7 14605 3 treatment treatment NN cord-005453-4057qib7 14605 4 ( ( -LRB- cord-005453-4057qib7 14605 5 % % NN cord-005453-4057qib7 14605 6 ) ) -RRB- cord-005453-4057qib7 14605 7 18 18 CD cord-005453-4057qib7 14605 8 ( ( -LRB- cord-005453-4057qib7 14605 9 24 24 CD cord-005453-4057qib7 14605 10 ) ) -RRB- cord-005453-4057qib7 14605 11 Disease Disease NNP cord-005453-4057qib7 14605 12 status status NN cord-005453-4057qib7 14605 13 at at IN cord-005453-4057qib7 14605 14 collection collection NN cord-005453-4057qib7 14605 15 ( ( -LRB- cord-005453-4057qib7 14605 16 % % NN cord-005453-4057qib7 14605 17 ) ) -RRB- cord-005453-4057qib7 14606 1 ≥PR ≥pr CD cord-005453-4057qib7 14607 1 -51 -51 NNP cord-005453-4057qib7 14608 1 ( ( -LRB- cord-005453-4057qib7 14608 2 Disclosure disclosure NN cord-005453-4057qib7 14608 3 : : : cord-005453-4057qib7 14608 4 Nothing nothing NN cord-005453-4057qib7 14608 5 to to TO cord-005453-4057qib7 14608 6 declare declare VB cord-005453-4057qib7 14608 7 P685 P685 NNP cord-005453-4057qib7 14608 8 Mobilization Mobilization NNP cord-005453-4057qib7 14608 9 with with IN cord-005453-4057qib7 14608 10 plerixafor plerixafor NN cord-005453-4057qib7 14608 11 in in IN cord-005453-4057qib7 14608 12 " " `` cord-005453-4057qib7 14608 13 poor poor JJ cord-005453-4057qib7 14608 14 mobilizer mobilizer NN cord-005453-4057qib7 14608 15 " " '' cord-005453-4057qib7 14608 16 related relate VBN cord-005453-4057qib7 14608 17 and and CC cord-005453-4057qib7 14608 18 unrelated unrelated JJ cord-005453-4057qib7 14608 19 donors donor NNS cord-005453-4057qib7 14608 20 of of IN cord-005453-4057qib7 14608 21 HPC HPC NNP cord-005453-4057qib7 14608 22 - - , cord-005453-4057qib7 14608 23 a a NN cord-005453-4057qib7 14608 24 in in IN cord-005453-4057qib7 14608 25 case case NN cord-005453-4057qib7 14608 26 of of IN cord-005453-4057qib7 14608 27 failed fail VBN cord-005453-4057qib7 14608 28 mobilization mobilization NN cord-005453-4057qib7 14608 29 with with IN cord-005453-4057qib7 14608 30 G G NNP cord-005453-4057qib7 14608 31 - - HYPH cord-005453-4057qib7 14608 32 CSF CSF NNP cord-005453-4057qib7 14608 33 Background Background NNP cord-005453-4057qib7 14608 34 : : : cord-005453-4057qib7 14608 35 In in IN cord-005453-4057qib7 14608 36 the the DT cord-005453-4057qib7 14608 37 allogeneic allogeneic JJ cord-005453-4057qib7 14608 38 HPC hpc NN cord-005453-4057qib7 14608 39 transplantation transplantation NN cord-005453-4057qib7 14608 40 , , , cord-005453-4057qib7 14608 41 both both CC cord-005453-4057qib7 14608 42 from from IN cord-005453-4057qib7 14608 43 related related JJ cord-005453-4057qib7 14608 44 and and CC cord-005453-4057qib7 14608 45 unrelated unrelated JJ cord-005453-4057qib7 14608 46 donors donor NNS cord-005453-4057qib7 14608 47 , , , cord-005453-4057qib7 14608 48 the the DT cord-005453-4057qib7 14608 49 most most RBS cord-005453-4057qib7 14608 50 commonly commonly RB cord-005453-4057qib7 14608 51 used use VBN cord-005453-4057qib7 14608 52 source source NN cord-005453-4057qib7 14608 53 is be VBZ cord-005453-4057qib7 14608 54 peripheral peripheral JJ cord-005453-4057qib7 14608 55 blood blood NN cord-005453-4057qib7 14608 56 after after IN cord-005453-4057qib7 14608 57 mobilization mobilization NN cord-005453-4057qib7 14608 58 with with IN cord-005453-4057qib7 14608 59 G G NNP cord-005453-4057qib7 14608 60 - - HYPH cord-005453-4057qib7 14608 61 CSF CSF NNP cord-005453-4057qib7 14608 62 . . . cord-005453-4057qib7 14609 1 It -PRON- PRP cord-005453-4057qib7 14609 2 is be VBZ cord-005453-4057qib7 14609 3 however however RB cord-005453-4057qib7 14609 4 known know VBN cord-005453-4057qib7 14609 5 that that IN cord-005453-4057qib7 14609 6 about about RB cord-005453-4057qib7 14609 7 2 2 CD cord-005453-4057qib7 14609 8 % % NN cord-005453-4057qib7 14609 9 of of IN cord-005453-4057qib7 14609 10 donors donor NNS cord-005453-4057qib7 14609 11 are be VBP cord-005453-4057qib7 14609 12 " " `` cord-005453-4057qib7 14609 13 poor poor JJ cord-005453-4057qib7 14609 14 mobilizers mobilizer NNS cord-005453-4057qib7 14609 15 " " '' cord-005453-4057qib7 14609 16 ; ; : cord-005453-4057qib7 14609 17 the the DT cord-005453-4057qib7 14609 18 rescue rescue NN cord-005453-4057qib7 14609 19 strategies strategy NNS cord-005453-4057qib7 14609 20 are be VBP cord-005453-4057qib7 14609 21 : : : cord-005453-4057qib7 14609 22 a a DT cord-005453-4057qib7 14609 23 third third JJ cord-005453-4057qib7 14609 24 apheretic apheretic JJ cord-005453-4057qib7 14609 25 collection collection NN cord-005453-4057qib7 14609 26 ; ; : cord-005453-4057qib7 14609 27 bone bone NN cord-005453-4057qib7 14609 28 marrow marrow NN cord-005453-4057qib7 14609 29 donation donation NN cord-005453-4057qib7 14609 30 . . . cord-005453-4057qib7 14610 1 Methods method NNS cord-005453-4057qib7 14610 2 : : : cord-005453-4057qib7 14611 1 In in IN cord-005453-4057qib7 14611 2 2016 2016 CD cord-005453-4057qib7 14611 3 - - SYM cord-005453-4057qib7 14611 4 2017 2017 CD cord-005453-4057qib7 14611 5 in in IN cord-005453-4057qib7 14611 6 Italy Italy NNP cord-005453-4057qib7 14611 7 a a DT cord-005453-4057qib7 14611 8 procedure procedure NN cord-005453-4057qib7 14611 9 to to TO cord-005453-4057qib7 14611 10 be be VB cord-005453-4057qib7 14611 11 adopted adopt VBN cord-005453-4057qib7 14611 12 in in IN cord-005453-4057qib7 14611 13 case case NN cord-005453-4057qib7 14611 14 of of IN cord-005453-4057qib7 14611 15 failed fail VBN cord-005453-4057qib7 14611 16 mobilization mobilization NN cord-005453-4057qib7 14611 17 of of IN cord-005453-4057qib7 14611 18 peripheral peripheral JJ cord-005453-4057qib7 14611 19 blood blood NN cord-005453-4057qib7 14611 20 stem stem NN cord-005453-4057qib7 14611 21 cells cell NNS cord-005453-4057qib7 14611 22 has have VBZ cord-005453-4057qib7 14611 23 been be VBN cord-005453-4057qib7 14611 24 defined define VBN cord-005453-4057qib7 14611 25 and and CC cord-005453-4057qib7 14611 26 shared share VBN cord-005453-4057qib7 14611 27 between between IN cord-005453-4057qib7 14611 28 IBMDR IBMDR NNP cord-005453-4057qib7 14611 29 , , , cord-005453-4057qib7 14611 30 CNT CNT NNP cord-005453-4057qib7 14611 31 ( ( -LRB- cord-005453-4057qib7 14611 32 Transplant Transplant NNP cord-005453-4057qib7 14611 33 National National NNP cord-005453-4057qib7 14611 34 Center Center NNP cord-005453-4057qib7 14611 35 ) ) -RRB- cord-005453-4057qib7 14611 36 and and CC cord-005453-4057qib7 14611 37 CNS CNS NNP cord-005453-4057qib7 14611 38 ( ( -LRB- cord-005453-4057qib7 14611 39 Blood Blood NNP cord-005453-4057qib7 14611 40 National National NNP cord-005453-4057qib7 14611 41 Center Center NNP cord-005453-4057qib7 14611 42 ) ) -RRB- cord-005453-4057qib7 14611 43 and and CC cord-005453-4057qib7 14611 44 the the DT cord-005453-4057qib7 14611 45 Scientific Scientific NNP cord-005453-4057qib7 14611 46 Societies Societies NNPS cord-005453-4057qib7 14611 47 SIMTI SIMTI NNP cord-005453-4057qib7 14611 48 , , , cord-005453-4057qib7 14611 49 SIdEM SIdEM NNP cord-005453-4057qib7 14611 50 and and CC cord-005453-4057qib7 14611 51 GITMO GITMO NNP cord-005453-4057qib7 14611 52 , , , cord-005453-4057qib7 14611 53 using use VBG cord-005453-4057qib7 14611 54 Plerixafor Plerixafor NNP cord-005453-4057qib7 14611 55 , , , cord-005453-4057qib7 14611 56 a a DT cord-005453-4057qib7 14611 57 selective selective JJ cord-005453-4057qib7 14611 58 reversible reversible JJ cord-005453-4057qib7 14611 59 antagonist antagonist NN cord-005453-4057qib7 14611 60 of of IN cord-005453-4057qib7 14611 61 the the DT cord-005453-4057qib7 14611 62 CXCR4 CXCR4 NNP cord-005453-4057qib7 14611 63 receptor receptor NN cord-005453-4057qib7 14611 64 with with IN cord-005453-4057qib7 14611 65 its -PRON- PRP$ cord-005453-4057qib7 14611 66 binder binder NN cord-005453-4057qib7 14611 67 ( ( -LRB- cord-005453-4057qib7 14611 68 the the DT cord-005453-4057qib7 14611 69 stromal stromal NN cord-005453-4057qib7 14611 70 derived derive VBN cord-005453-4057qib7 14611 71 factor factor NN cord-005453-4057qib7 14611 72 SDF-1 SDF-1 NNP cord-005453-4057qib7 14611 73 ) ) -RRB- cord-005453-4057qib7 14611 74 , , , cord-005453-4057qib7 14611 75 in in IN cord-005453-4057qib7 14611 76 combination combination NN cord-005453-4057qib7 14611 77 with with IN cord-005453-4057qib7 14611 78 standard standard JJ cord-005453-4057qib7 14611 79 G G NNP cord-005453-4057qib7 14611 80 - - HYPH cord-005453-4057qib7 14611 81 CSF CSF NNP cord-005453-4057qib7 14611 82 dose dose NN cord-005453-4057qib7 14611 83 . . . cord-005453-4057qib7 14612 1 Moreover moreover RB cord-005453-4057qib7 14612 2 since since IN cord-005453-4057qib7 14612 3 2017 2017 CD cord-005453-4057qib7 14612 4 , , , cord-005453-4057qib7 14612 5 in in IN cord-005453-4057qib7 14612 6 accordance accordance NN cord-005453-4057qib7 14612 7 with with IN cord-005453-4057qib7 14612 8 this this DT cord-005453-4057qib7 14612 9 protocol protocol NN cord-005453-4057qib7 14612 10 , , , cord-005453-4057qib7 14612 11 the the DT cord-005453-4057qib7 14612 12 Competent Competent NNP cord-005453-4057qib7 14612 13 Authority Authority NNP cord-005453-4057qib7 14612 14 ( ( -LRB- cord-005453-4057qib7 14612 15 AIFA AIFA NNP cord-005453-4057qib7 14612 16 ) ) -RRB- cord-005453-4057qib7 14612 17 has have VBZ cord-005453-4057qib7 14612 18 extended extend VBN cord-005453-4057qib7 14612 19 the the DT cord-005453-4057qib7 14612 20 registration registration NN cord-005453-4057qib7 14612 21 of of IN cord-005453-4057qib7 14612 22 Plerixafor Plerixafor NNP cord-005453-4057qib7 14612 23 ( ( -LRB- cord-005453-4057qib7 14612 24 Law Law NNP cord-005453-4057qib7 14612 25 no.648/96 no.648/96 NNP cord-005453-4057qib7 14612 26 ) ) -RRB- cord-005453-4057qib7 14612 27 , , , cord-005453-4057qib7 14612 28 also also RB cord-005453-4057qib7 14612 29 for for IN cord-005453-4057qib7 14612 30 the the DT cord-005453-4057qib7 14612 31 mobilization mobilization NN cord-005453-4057qib7 14612 32 in in IN cord-005453-4057qib7 14612 33 " " `` cord-005453-4057qib7 14612 34 poor poor JJ cord-005453-4057qib7 14612 35 mobilizer mobilizer NN cord-005453-4057qib7 14612 36 " " '' cord-005453-4057qib7 14612 37 healthy healthy JJ cord-005453-4057qib7 14612 38 donors donor NNS cord-005453-4057qib7 14612 39 . . . cord-005453-4057qib7 14613 1 Finally finally RB cord-005453-4057qib7 14613 2 , , , cord-005453-4057qib7 14613 3 in in IN cord-005453-4057qib7 14613 4 2018 2018 CD cord-005453-4057qib7 14613 5 the the DT cord-005453-4057qib7 14613 6 protocol protocol NN cord-005453-4057qib7 14613 7 was be VBD cord-005453-4057qib7 14613 8 extended extend VBN cord-005453-4057qib7 14613 9 to to IN cord-005453-4057qib7 14613 10 " " `` cord-005453-4057qib7 14613 11 poor poor JJ cord-005453-4057qib7 14613 12 mobilizer mobilizer NN cord-005453-4057qib7 14613 13 " " '' cord-005453-4057qib7 14613 14 family family NN cord-005453-4057qib7 14613 15 donors donor NNS cord-005453-4057qib7 14613 16 , , , cord-005453-4057qib7 14613 17 making make VBG cord-005453-4057qib7 14613 18 management management NN cord-005453-4057qib7 14613 19 equivalent equivalent JJ cord-005453-4057qib7 14613 20 in in IN cord-005453-4057qib7 14613 21 related related JJ cord-005453-4057qib7 14613 22 and and CC cord-005453-4057qib7 14613 23 unrelated unrelated JJ cord-005453-4057qib7 14613 24 donors donor NNS cord-005453-4057qib7 14613 25 . . . cord-005453-4057qib7 14614 1 At at IN cord-005453-4057qib7 14614 2 the the DT cord-005453-4057qib7 14614 3 time time NN cord-005453-4057qib7 14614 4 of of IN cord-005453-4057qib7 14614 5 the the DT cord-005453-4057qib7 14614 6 donor´s donor´s NNP cord-005453-4057qib7 14614 7 informed informed JJ cord-005453-4057qib7 14614 8 consent consent NN cord-005453-4057qib7 14614 9 for for IN cord-005453-4057qib7 14614 10 the the DT cord-005453-4057qib7 14614 11 donation donation NN cord-005453-4057qib7 14614 12 of of IN cord-005453-4057qib7 14614 13 HPC HPC NNP cord-005453-4057qib7 14614 14 , , , cord-005453-4057qib7 14614 15 the the DT cord-005453-4057qib7 14614 16 hypothesis hypothesis NN cord-005453-4057qib7 14614 17 of of IN cord-005453-4057qib7 14614 18 the the DT cord-005453-4057qib7 14614 19 lack lack NN cord-005453-4057qib7 14614 20 of of IN cord-005453-4057qib7 14614 21 mobilization mobilization NN cord-005453-4057qib7 14614 22 or or CC cord-005453-4057qib7 14614 23 inadequate inadequate JJ cord-005453-4057qib7 14614 24 collection collection NN cord-005453-4057qib7 14614 25 was be VBD cord-005453-4057qib7 14614 26 illustrated illustrate VBN cord-005453-4057qib7 14614 27 and and CC cord-005453-4057qib7 14614 28 the the DT cord-005453-4057qib7 14614 29 possible possible JJ cord-005453-4057qib7 14614 30 actions action NNS cord-005453-4057qib7 14614 31 proposed propose VBN cord-005453-4057qib7 14614 32 as as IN cord-005453-4057qib7 14614 33 " " `` cord-005453-4057qib7 14614 34 back back RB cord-005453-4057qib7 14614 35 - - HYPH cord-005453-4057qib7 14614 36 up up RP cord-005453-4057qib7 14614 37 donation donation NN cord-005453-4057qib7 14614 38 " " '' cord-005453-4057qib7 14614 39 were be VBD cord-005453-4057qib7 14614 40 anticipated anticipate VBN cord-005453-4057qib7 14614 41 . . . cord-005453-4057qib7 14615 1 Failed fail VBN cord-005453-4057qib7 14615 2 mobilization mobilization NN cord-005453-4057qib7 14615 3 of of IN cord-005453-4057qib7 14615 4 CSE CSE NNP cord-005453-4057qib7 14615 5 has have VBZ cord-005453-4057qib7 14615 6 been be VBN cord-005453-4057qib7 14615 7 defined define VBN cord-005453-4057qib7 14615 8 as as IN cord-005453-4057qib7 14615 9 the the DT cord-005453-4057qib7 14615 10 presence presence NN cord-005453-4057qib7 14615 11 of of IN cord-005453-4057qib7 14615 12 one one CD cord-005453-4057qib7 14615 13 of of IN cord-005453-4057qib7 14615 14 the the DT cord-005453-4057qib7 14615 15 two two CD cord-005453-4057qib7 14615 16 criteria criterion NNS cord-005453-4057qib7 14615 17 : : : cord-005453-4057qib7 14615 18 a a DT cord-005453-4057qib7 14615 19 number number NN cord-005453-4057qib7 14615 20 of of IN cord-005453-4057qib7 14615 21 CD34 CD34 NNP cord-005453-4057qib7 14615 22 + + CC cord-005453-4057qib7 14615 23 circulating circulate VBG cord-005453-4057qib7 14615 24 on on IN cord-005453-4057qib7 14615 25 peripheral peripheral JJ cord-005453-4057qib7 14615 26 blood blood NN cord-005453-4057qib7 14615 27 lower low JJR cord-005453-4057qib7 14615 28 than than IN cord-005453-4057qib7 14615 29 20 20 CD cord-005453-4057qib7 14616 1 /μL /μL . cord-005453-4057qib7 14617 1 on on IN cord-005453-4057qib7 14617 2 the the DT cord-005453-4057qib7 14617 3 5th 5th JJ cord-005453-4057qib7 14617 4 day day NN cord-005453-4057qib7 14617 5 of of IN cord-005453-4057qib7 14617 6 stimulation stimulation NN cord-005453-4057qib7 14617 7 ( ( -LRB- cord-005453-4057qib7 14617 8 5D 5D NNP cord-005453-4057qib7 14617 9 ) ) -RRB- cord-005453-4057qib7 14617 10 , , , cord-005453-4057qib7 14617 11 or or CC cord-005453-4057qib7 14617 12 the the DT cord-005453-4057qib7 14617 13 collection collection NN cord-005453-4057qib7 14617 14 of of IN cord-005453-4057qib7 14617 15 CD34 CD34 NNP cord-005453-4057qib7 14617 16 + + SYM cord-005453-4057qib7 14617 17 < < XX cord-005453-4057qib7 14617 18 1.0x106 1.0x106 NNP cord-005453-4057qib7 14617 19 / / SYM cord-005453-4057qib7 14617 20 kg kg NN cord-005453-4057qib7 14617 21 weight weight NN cord-005453-4057qib7 14617 22 of of IN cord-005453-4057qib7 14617 23 the the DT cord-005453-4057qib7 14617 24 recipient recipient NN cord-005453-4057qib7 14617 25 at at IN cord-005453-4057qib7 14617 26 first first JJ cord-005453-4057qib7 14617 27 apheresis apheresis NN cord-005453-4057qib7 14617 28 . . . cord-005453-4057qib7 14618 1 In in IN cord-005453-4057qib7 14618 2 these these DT cord-005453-4057qib7 14618 3 cases case NNS cord-005453-4057qib7 14618 4 , , , cord-005453-4057qib7 14618 5 a a DT cord-005453-4057qib7 14618 6 single single JJ cord-005453-4057qib7 14618 7 dose dose NN cord-005453-4057qib7 14618 8 of of IN cord-005453-4057qib7 14618 9 Plerixafor Plerixafor NNP cord-005453-4057qib7 14618 10 is be VBZ cord-005453-4057qib7 14618 11 administered administer VBN cord-005453-4057qib7 14618 12 subcutaneously subcutaneously RB cord-005453-4057qib7 14618 13 by by IN cord-005453-4057qib7 14618 14 health health NN cord-005453-4057qib7 14618 15 professionals professional NNS cord-005453-4057qib7 14618 16 under under IN cord-005453-4057qib7 14618 17 medical medical JJ cord-005453-4057qib7 14618 18 supervision supervision NN cord-005453-4057qib7 14618 19 , , , cord-005453-4057qib7 14618 20 0.24mg 0.24mg CD cord-005453-4057qib7 14618 21 / / SYM cord-005453-4057qib7 14618 22 kg kg NNS cord-005453-4057qib7 14618 23 of of IN cord-005453-4057qib7 14618 24 body body NN cord-005453-4057qib7 14618 25 weight weight NN cord-005453-4057qib7 14618 26 , , , cord-005453-4057qib7 14618 27 6 6 CD cord-005453-4057qib7 14618 28 - - SYM cord-005453-4057qib7 14618 29 11 11 CD cord-005453-4057qib7 14618 30 hours hour NNS cord-005453-4057qib7 14618 31 before before IN cord-005453-4057qib7 14618 32 the the DT cord-005453-4057qib7 14618 33 start start NN cord-005453-4057qib7 14618 34 of of IN cord-005453-4057qib7 14618 35 apheresis apheresis NN cord-005453-4057qib7 14618 36 . . . cord-005453-4057qib7 14619 1 In in IN cord-005453-4057qib7 14619 2 case case NN cord-005453-4057qib7 14619 3 of of IN cord-005453-4057qib7 14619 4 use use NN cord-005453-4057qib7 14619 5 Plerixafor Plerixafor NNP cord-005453-4057qib7 14619 6 due due JJ cord-005453-4057qib7 14619 7 to to IN cord-005453-4057qib7 14619 8 failed fail VBN cord-005453-4057qib7 14619 9 mobilization mobilization NN cord-005453-4057qib7 14619 10 of of IN cord-005453-4057qib7 14619 11 HPC HPC NNP cord-005453-4057qib7 14619 12 - - HYPH cord-005453-4057qib7 14619 13 A a NN cord-005453-4057qib7 14619 14 or or CC cord-005453-4057qib7 14619 15 collection collection NN cord-005453-4057qib7 14619 16 of of IN cord-005453-4057qib7 14619 17 an an DT cord-005453-4057qib7 14619 18 inappropriate inappropriate JJ cord-005453-4057qib7 14619 19 number number NN cord-005453-4057qib7 14619 20 of of IN cord-005453-4057qib7 14619 21 CD34 CD34 NNP cord-005453-4057qib7 14619 22 + + SYM cord-005453-4057qib7 14619 23 , , , cord-005453-4057qib7 14619 24 the the DT cord-005453-4057qib7 14619 25 notification notification NN cord-005453-4057qib7 14619 26 is be VBZ cord-005453-4057qib7 14619 27 made make VBN cord-005453-4057qib7 14619 28 by by IN cord-005453-4057qib7 14619 29 the the DT cord-005453-4057qib7 14619 30 Collection Collection NNP cord-005453-4057qib7 14619 31 Center Center NNP cord-005453-4057qib7 14619 32 to to IN cord-005453-4057qib7 14619 33 IBMDR IBMDR NNP cord-005453-4057qib7 14619 34 ( ( -LRB- cord-005453-4057qib7 14619 35 for for IN cord-005453-4057qib7 14619 36 both both DT cord-005453-4057qib7 14619 37 family family NN cord-005453-4057qib7 14619 38 and and CC cord-005453-4057qib7 14619 39 non non JJ cord-005453-4057qib7 14619 40 - - JJ cord-005453-4057qib7 14619 41 family family JJ cord-005453-4057qib7 14619 42 donors donor NNS cord-005453-4057qib7 14619 43 ) ) -RRB- cord-005453-4057qib7 14619 44 , , , cord-005453-4057qib7 14619 45 and and CC cord-005453-4057qib7 14619 46 to to IN cord-005453-4057qib7 14619 47 the the DT cord-005453-4057qib7 14619 48 recipient recipient NN cord-005453-4057qib7 14619 49 Transplant Transplant NNP cord-005453-4057qib7 14619 50 Center Center NNP cord-005453-4057qib7 14619 51 : : : cord-005453-4057qib7 14619 52 both both DT cord-005453-4057qib7 14619 53 donor donor NN cord-005453-4057qib7 14619 54 and and CC cord-005453-4057qib7 14619 55 recipient recipient NN cord-005453-4057qib7 14619 56 express express VBP cord-005453-4057qib7 14619 57 their -PRON- PRP$ cord-005453-4057qib7 14619 58 consent consent NN cord-005453-4057qib7 14619 59 ; ; : cord-005453-4057qib7 14619 60 finally finally RB cord-005453-4057qib7 14619 61 once once IN cord-005453-4057qib7 14619 62 the the DT cord-005453-4057qib7 14619 63 collection collection NN cord-005453-4057qib7 14619 64 is be VBZ cord-005453-4057qib7 14619 65 completed complete VBN cord-005453-4057qib7 14619 66 , , , cord-005453-4057qib7 14619 67 the the DT cord-005453-4057qib7 14619 68 Collection Collection NNP cord-005453-4057qib7 14619 69 Center Center NNP cord-005453-4057qib7 14619 70 informs inform VBZ cord-005453-4057qib7 14619 71 IBMDR IBMDR NNP cord-005453-4057qib7 14619 72 , , , cord-005453-4057qib7 14619 73 which which WDT cord-005453-4057qib7 14619 74 in in IN cord-005453-4057qib7 14619 75 turn turn NN cord-005453-4057qib7 14619 76 notifies notify VBZ cord-005453-4057qib7 14619 77 CNT CNT NNP cord-005453-4057qib7 14619 78 / / SYM cord-005453-4057qib7 14619 79 CNS CNS NNP cord-005453-4057qib7 14619 80 / / SYM cord-005453-4057qib7 14619 81 SIMTI SIMTI NNP cord-005453-4057qib7 14619 82 / / SYM cord-005453-4057qib7 14619 83 SIDEM SIDEM NNP cord-005453-4057qib7 14619 84 / / SYM cord-005453-4057qib7 14619 85 GITMO GITMO NNP cord-005453-4057qib7 14619 86 . . . cord-005453-4057qib7 14620 1 Any any DT cord-005453-4057qib7 14620 2 adverse adverse JJ cord-005453-4057qib7 14620 3 reactions reaction NNS cord-005453-4057qib7 14620 4 / / SYM cord-005453-4057qib7 14620 5 events event NNS cord-005453-4057qib7 14620 6 are be VBP cord-005453-4057qib7 14620 7 notified notify VBN cord-005453-4057qib7 14620 8 in in IN cord-005453-4057qib7 14620 9 real real JJ cord-005453-4057qib7 14620 10 time time NN cord-005453-4057qib7 14620 11 , , , cord-005453-4057qib7 14620 12 based base VBN cord-005453-4057qib7 14620 13 on on IN cord-005453-4057qib7 14620 14 the the DT cord-005453-4057qib7 14620 15 SOP sop NN cord-005453-4057qib7 14620 16 specifications specification NNS cord-005453-4057qib7 14620 17 and and CC cord-005453-4057qib7 14620 18 current current JJ cord-005453-4057qib7 14620 19 regulations regulation NNS cord-005453-4057qib7 14620 20 . . . cord-005453-4057qib7 14621 1 Results result NNS cord-005453-4057qib7 14621 2 : : : cord-005453-4057qib7 14622 1 Since since IN cord-005453-4057qib7 14622 2 the the DT cord-005453-4057qib7 14622 3 introduction introduction NN cord-005453-4057qib7 14622 4 of of IN cord-005453-4057qib7 14622 5 the the DT cord-005453-4057qib7 14622 6 national national JJ cord-005453-4057qib7 14622 7 protocol protocol NN cord-005453-4057qib7 14622 8 , , , cord-005453-4057qib7 14622 9 7 7 CD cord-005453-4057qib7 14622 10 donors donor NNS cord-005453-4057qib7 14622 11 ( ( -LRB- cord-005453-4057qib7 14622 12 4 4 CD cord-005453-4057qib7 14622 13 unrelated unrelated JJ cord-005453-4057qib7 14622 14 donors donor NNS cord-005453-4057qib7 14622 15 and and CC cord-005453-4057qib7 14622 16 3 3 CD cord-005453-4057qib7 14622 17 related related JJ cord-005453-4057qib7 14622 18 donors donor NNS cord-005453-4057qib7 14622 19 ) ) -RRB- cord-005453-4057qib7 14622 20 were be VBD cord-005453-4057qib7 14622 21 treated treat VBN cord-005453-4057qib7 14622 22 , , , cord-005453-4057qib7 14622 23 presenting present VBG cord-005453-4057qib7 14622 24 at at RB cord-005453-4057qib7 14622 25 least least RBS cord-005453-4057qib7 14622 26 one one CD cord-005453-4057qib7 14622 27 of of IN cord-005453-4057qib7 14622 28 the the DT cord-005453-4057qib7 14622 29 two two CD cord-005453-4057qib7 14622 30 inclusion inclusion NN cord-005453-4057qib7 14622 31 criteria criterion NNS cord-005453-4057qib7 14622 32 ( ( -LRB- cord-005453-4057qib7 14622 33 CD34 CD34 NNP cord-005453-4057qib7 14622 34 < < XX cord-005453-4057qib7 14622 35 20/ 20/ CD cord-005453-4057qib7 14623 1 μL μL . cord-005453-4057qib7 14624 1 at at IN cord-005453-4057qib7 14624 2 5D 5d CD cord-005453-4057qib7 14624 3 or or CC cord-005453-4057qib7 14624 4 CD34 CD34 NNP cord-005453-4057qib7 14624 5 < < XX cord-005453-4057qib7 14624 6 1x10e6 1x10e6 NNP cord-005453-4057qib7 14624 7 / / SYM cord-005453-4057qib7 14624 8 Kg Kg NNP cord-005453-4057qib7 14624 9 after after IN cord-005453-4057qib7 14624 10 first first JJ cord-005453-4057qib7 14624 11 collection)After collection)after NN cord-005453-4057qib7 14624 12 use use NN cord-005453-4057qib7 14624 13 of of IN cord-005453-4057qib7 14624 14 Plerixafor Plerixafor NNP cord-005453-4057qib7 14624 15 in in IN cord-005453-4057qib7 14624 16 all all DT cord-005453-4057qib7 14624 17 donors donor NNS cord-005453-4057qib7 14624 18 , , , cord-005453-4057qib7 14624 19 the the DT cord-005453-4057qib7 14624 20 required require VBN cord-005453-4057qib7 14624 21 dose dose NN cord-005453-4057qib7 14624 22 of of IN cord-005453-4057qib7 14624 23 CD34 CD34 NNP cord-005453-4057qib7 14624 24 was be VBD cord-005453-4057qib7 14624 25 obtained obtain VBN cord-005453-4057qib7 14624 26 to to TO cord-005453-4057qib7 14624 27 ensure ensure VB cord-005453-4057qib7 14624 28 successful successful JJ cord-005453-4057qib7 14624 29 transplantation transplantation NN cord-005453-4057qib7 14624 30 , , , cord-005453-4057qib7 14624 31 with with IN cord-005453-4057qib7 14624 32 a a DT cord-005453-4057qib7 14624 33 sufficient sufficient JJ cord-005453-4057qib7 14624 34 increase increase NN cord-005453-4057qib7 14624 35 in in IN cord-005453-4057qib7 14624 36 the the DT cord-005453-4057qib7 14624 37 CD34 CD34 NNP cord-005453-4057qib7 14624 38 + + CC cord-005453-4057qib7 14624 39 cells cell NNS cord-005453-4057qib7 14624 40 . . . cord-005453-4057qib7 14625 1 No no DT cord-005453-4057qib7 14625 2 side side NN cord-005453-4057qib7 14625 3 effects effect NNS cord-005453-4057qib7 14625 4 or or CC cord-005453-4057qib7 14625 5 adverse adverse JJ cord-005453-4057qib7 14625 6 reactions reaction NNS cord-005453-4057qib7 14625 7 related relate VBN cord-005453-4057qib7 14625 8 to to IN cord-005453-4057qib7 14625 9 the the DT cord-005453-4057qib7 14625 10 administration administration NN cord-005453-4057qib7 14625 11 of of IN cord-005453-4057qib7 14625 12 Plerixafor Plerixafor NNP cord-005453-4057qib7 14625 13 occurred occur VBD cord-005453-4057qib7 14625 14 . . . cord-005453-4057qib7 14626 1 Conclusions conclusion NNS cord-005453-4057qib7 14626 2 : : : cord-005453-4057qib7 14627 1 In in IN cord-005453-4057qib7 14627 2 cases case NNS cord-005453-4057qib7 14627 3 of of IN cord-005453-4057qib7 14627 4 failed fail VBN cord-005453-4057qib7 14627 5 mobilization mobilization NN cord-005453-4057qib7 14627 6 in in IN cord-005453-4057qib7 14627 7 the the DT cord-005453-4057qib7 14627 8 related related JJ cord-005453-4057qib7 14627 9 and and CC cord-005453-4057qib7 14627 10 unrelated unrelated JJ cord-005453-4057qib7 14627 11 donor donor NN cord-005453-4057qib7 14627 12 , , , cord-005453-4057qib7 14627 13 the the DT cord-005453-4057qib7 14627 14 use use NN cord-005453-4057qib7 14627 15 of of IN cord-005453-4057qib7 14627 16 Plerixafor Plerixafor NNP cord-005453-4057qib7 14627 17 according accord VBG cord-005453-4057qib7 14627 18 to to IN cord-005453-4057qib7 14627 19 the the DT cord-005453-4057qib7 14627 20 methods method NNS cord-005453-4057qib7 14627 21 described describe VBN cord-005453-4057qib7 14627 22 in in IN cord-005453-4057qib7 14627 23 the the DT cord-005453-4057qib7 14627 24 shared share VBN cord-005453-4057qib7 14627 25 protocol protocol NN cord-005453-4057qib7 14627 26 between between IN cord-005453-4057qib7 14627 27 IBMDR IBMDR NNP cord-005453-4057qib7 14627 28 , , , cord-005453-4057qib7 14627 29 CNS CNS NNP cord-005453-4057qib7 14627 30 , , , cord-005453-4057qib7 14627 31 CNT CNT NNP cord-005453-4057qib7 14627 32 , , , cord-005453-4057qib7 14627 33 SIMTI SIMTI NNP cord-005453-4057qib7 14627 34 , , , cord-005453-4057qib7 14627 35 SIdEM SIdEM NNP cord-005453-4057qib7 14627 36 , , , cord-005453-4057qib7 14627 37 GITMO GITMO NNP cord-005453-4057qib7 14627 38 , , , cord-005453-4057qib7 14627 39 proved prove VBD cord-005453-4057qib7 14627 40 to to TO cord-005453-4057qib7 14627 41 be be VB cord-005453-4057qib7 14627 42 safe safe JJ cord-005453-4057qib7 14627 43 and and CC cord-005453-4057qib7 14627 44 effective effective JJ cord-005453-4057qib7 14627 45 . . . cord-005453-4057qib7 14628 1 This this DT cord-005453-4057qib7 14628 2 protocol protocol NN cord-005453-4057qib7 14628 3 emphasizes emphasize VBZ cord-005453-4057qib7 14628 4 the the DT cord-005453-4057qib7 14628 5 great great JJ cord-005453-4057qib7 14628 6 value value NN cord-005453-4057qib7 14628 7 of of IN cord-005453-4057qib7 14628 8 the the DT cord-005453-4057qib7 14628 9 sharing sharing NN cord-005453-4057qib7 14628 10 of of IN cord-005453-4057qib7 14628 11 procedures procedure NNS cord-005453-4057qib7 14628 12 between between IN cord-005453-4057qib7 14628 13 the the DT cord-005453-4057qib7 14628 14 register register NN cord-005453-4057qib7 14628 15 , , , cord-005453-4057qib7 14628 16 institutions institution NNS cord-005453-4057qib7 14628 17 and and CC cord-005453-4057qib7 14628 18 scientific scientific JJ cord-005453-4057qib7 14628 19 societies society NNS cord-005453-4057qib7 14628 20 , , , cord-005453-4057qib7 14628 21 ensuring ensure VBG cord-005453-4057qib7 14628 22 the the DT cord-005453-4057qib7 14628 23 supervision supervision NN cord-005453-4057qib7 14628 24 of of IN cord-005453-4057qib7 14628 25 the the DT cord-005453-4057qib7 14628 26 process process NN cord-005453-4057qib7 14628 27 and and CC cord-005453-4057qib7 14628 28 the the DT cord-005453-4057qib7 14628 29 protection protection NN cord-005453-4057qib7 14628 30 of of IN cord-005453-4057qib7 14628 31 the the DT cord-005453-4057qib7 14628 32 donor donor NN cord-005453-4057qib7 14628 33 and and CC cord-005453-4057qib7 14628 34 recipient recipient NN cord-005453-4057qib7 14628 35 . . . cord-005453-4057qib7 14629 1 Disclosure disclosure NN cord-005453-4057qib7 14629 2 : : : cord-005453-4057qib7 14629 3 Nothing nothing NN cord-005453-4057qib7 14629 4 to to TO cord-005453-4057qib7 14629 5 declare declare VB cord-005453-4057qib7 14629 6 Background background NN cord-005453-4057qib7 14629 7 : : : cord-005453-4057qib7 14629 8 Autologous autologous JJ cord-005453-4057qib7 14629 9 stem stem NN cord-005453-4057qib7 14629 10 cells cell NNS cord-005453-4057qib7 14629 11 transplantation transplantation NN cord-005453-4057qib7 14629 12 ( ( -LRB- cord-005453-4057qib7 14629 13 ASCT ASCT NNP cord-005453-4057qib7 14629 14 ) ) -RRB- cord-005453-4057qib7 14629 15 is be VBZ cord-005453-4057qib7 14629 16 an an DT cord-005453-4057qib7 14629 17 effective effective JJ cord-005453-4057qib7 14629 18 treatment treatment NN cord-005453-4057qib7 14629 19 option option NN cord-005453-4057qib7 14629 20 for for IN cord-005453-4057qib7 14629 21 young young JJ cord-005453-4057qib7 14629 22 patients patient NNS cord-005453-4057qib7 14629 23 with with IN cord-005453-4057qib7 14629 24 multiple multiple JJ cord-005453-4057qib7 14629 25 myeloma myeloma NN cord-005453-4057qib7 14629 26 ( ( -LRB- cord-005453-4057qib7 14629 27 MM MM NNP cord-005453-4057qib7 14629 28 ) ) -RRB- cord-005453-4057qib7 14629 29 . . . cord-005453-4057qib7 14630 1 A a DT cord-005453-4057qib7 14630 2 minority minority NN cord-005453-4057qib7 14630 3 of of IN cord-005453-4057qib7 14630 4 patients patient NNS cord-005453-4057qib7 14630 5 may may MD cord-005453-4057qib7 14630 6 still still RB cord-005453-4057qib7 14630 7 experience experience VB cord-005453-4057qib7 14630 8 untoward untoward JJ cord-005453-4057qib7 14630 9 toxicity toxicity NN cord-005453-4057qib7 14630 10 due due IN cord-005453-4057qib7 14630 11 to to IN cord-005453-4057qib7 14630 12 delayed delay VBN cord-005453-4057qib7 14630 13 engraftment engraftment NN cord-005453-4057qib7 14630 14 . . . cord-005453-4057qib7 14631 1 Thus thus RB cord-005453-4057qib7 14631 2 , , , cord-005453-4057qib7 14631 3 the the DT cord-005453-4057qib7 14631 4 current current JJ cord-005453-4057qib7 14631 5 policy policy NN cord-005453-4057qib7 14631 6 in in IN cord-005453-4057qib7 14631 7 many many JJ cord-005453-4057qib7 14631 8 centers center NNS cord-005453-4057qib7 14631 9 is be VBZ cord-005453-4057qib7 14631 10 aimed aim VBN cord-005453-4057qib7 14631 11 to to TO cord-005453-4057qib7 14631 12 increase increase VB cord-005453-4057qib7 14631 13 the the DT cord-005453-4057qib7 14631 14 target target NN cord-005453-4057qib7 14631 15 dose dose NN cord-005453-4057qib7 14631 16 of of IN cord-005453-4057qib7 14631 17 collected collect VBN cord-005453-4057qib7 14631 18 CD34 CD34 NNP cord-005453-4057qib7 14631 19 + + CC cord-005453-4057qib7 14631 20 cells cell NNS cord-005453-4057qib7 14631 21 up up IN cord-005453-4057qib7 14631 22 to to IN cord-005453-4057qib7 14631 23 an an DT cord-005453-4057qib7 14631 24 " " `` cord-005453-4057qib7 14631 25 optimal optimal JJ cord-005453-4057qib7 14631 26 " " '' cord-005453-4057qib7 14631 27 level level NN cord-005453-4057qib7 14631 28 of of IN cord-005453-4057qib7 14631 29 4x10 4x10 CD cord-005453-4057qib7 14631 30 6 6 CD cord-005453-4057qib7 14631 31 /Kg /Kg . cord-005453-4057qib7 14632 1 per per IN cord-005453-4057qib7 14632 2 procedure procedure NN cord-005453-4057qib7 14632 3 . . . cord-005453-4057qib7 14633 1 Therefore therefore RB cord-005453-4057qib7 14633 2 , , , cord-005453-4057qib7 14633 3 an an DT cord-005453-4057qib7 14633 4 ideal ideal JJ cord-005453-4057qib7 14633 5 mobilization mobilization NN cord-005453-4057qib7 14633 6 , , , cord-005453-4057qib7 14633 7 aimed aim VBN cord-005453-4057qib7 14633 8 to to TO cord-005453-4057qib7 14633 9 collect collect VB cord-005453-4057qib7 14633 10 4 4 CD cord-005453-4057qib7 14633 11 to to TO cord-005453-4057qib7 14633 12 8 8 CD cord-005453-4057qib7 14633 13 CD34 CD34 NNP cord-005453-4057qib7 14633 14 + + CC cord-005453-4057qib7 14633 15 cells cell NNS cord-005453-4057qib7 14633 16 / / SYM cord-005453-4057qib7 14633 17 kg kg NNS cord-005453-4057qib7 14633 18 in in IN cord-005453-4057qib7 14633 19 one one CD cord-005453-4057qib7 14633 20 apheresis apheresis NN cord-005453-4057qib7 14633 21 , , , cord-005453-4057qib7 14633 22 should should MD cord-005453-4057qib7 14633 23 achieve achieve VB cord-005453-4057qib7 14633 24 a a DT cord-005453-4057qib7 14633 25 number number NN cord-005453-4057qib7 14633 26 of of IN cord-005453-4057qib7 14633 27 circulating circulate VBG cord-005453-4057qib7 14633 28 CD34 CD34 NNP cord-005453-4057qib7 14633 29 + + CC cord-005453-4057qib7 14633 30 cells cell NNS cord-005453-4057qib7 14633 31 > > XX cord-005453-4057qib7 14634 1 40 40 CD cord-005453-4057qib7 14634 2 / / SYM cord-005453-4057qib7 14634 3 mcL mcl NN cord-005453-4057qib7 14634 4 ( ( -LRB- cord-005453-4057qib7 14634 5 very very RB cord-005453-4057qib7 14634 6 good good JJ cord-005453-4057qib7 14634 7 mobilizers mobilizer NNS cord-005453-4057qib7 14634 8 ) ) -RRB- cord-005453-4057qib7 14634 9 . . . cord-005453-4057qib7 14635 1 Plerixafor Plerixafor NNP cord-005453-4057qib7 14635 2 may may MD cord-005453-4057qib7 14635 3 help help VB cord-005453-4057qib7 14635 4 to to TO cord-005453-4057qib7 14635 5 maximize maximize VB cord-005453-4057qib7 14635 6 the the DT cord-005453-4057qib7 14635 7 CD34 CD34 NNP cord-005453-4057qib7 14635 8 + + CC cord-005453-4057qib7 14635 9 collection collection NN cord-005453-4057qib7 14635 10 but but CC cord-005453-4057qib7 14635 11 its -PRON- PRP$ cord-005453-4057qib7 14635 12 use use NN cord-005453-4057qib7 14635 13 is be VBZ cord-005453-4057qib7 14635 14 limited limit VBN cord-005453-4057qib7 14635 15 by by IN cord-005453-4057qib7 14635 16 high high JJ cord-005453-4057qib7 14635 17 cost cost NN cord-005453-4057qib7 14635 18 . . . cord-005453-4057qib7 14636 1 We -PRON- PRP cord-005453-4057qib7 14636 2 carried carry VBD cord-005453-4057qib7 14636 3 out out RP cord-005453-4057qib7 14636 4 a a DT cord-005453-4057qib7 14636 5 retrospective retrospective JJ cord-005453-4057qib7 14636 6 analysis analysis NN cord-005453-4057qib7 14636 7 aimed aim VBN cord-005453-4057qib7 14636 8 to to TO cord-005453-4057qib7 14636 9 predict predict VB cord-005453-4057qib7 14636 10 the the DT cord-005453-4057qib7 14636 11 quality quality NN cord-005453-4057qib7 14636 12 of of IN cord-005453-4057qib7 14636 13 mobilization mobilization NN cord-005453-4057qib7 14636 14 and and CC cord-005453-4057qib7 14636 15 develop develop VB cord-005453-4057qib7 14636 16 an an DT cord-005453-4057qib7 14636 17 algorithm algorithm NN cord-005453-4057qib7 14636 18 to to TO cord-005453-4057qib7 14636 19 optimize optimize VB cord-005453-4057qib7 14636 20 both both DT cord-005453-4057qib7 14636 21 timing timing NN cord-005453-4057qib7 14636 22 of of IN cord-005453-4057qib7 14636 23 collection collection NN cord-005453-4057qib7 14636 24 and and CC cord-005453-4057qib7 14636 25 use use NN cord-005453-4057qib7 14636 26 of of IN cord-005453-4057qib7 14636 27 Plerixafor Plerixafor NNP cord-005453-4057qib7 14636 28 . . . cord-005453-4057qib7 14637 1 Methods method NNS cord-005453-4057qib7 14637 2 : : : cord-005453-4057qib7 14637 3 We -PRON- PRP cord-005453-4057qib7 14637 4 retrospectively retrospectively RB cord-005453-4057qib7 14637 5 collected collect VBD cord-005453-4057qib7 14637 6 data datum NNS cord-005453-4057qib7 14637 7 from from IN cord-005453-4057qib7 14637 8 91 91 CD cord-005453-4057qib7 14637 9 mobilization mobilization NN cord-005453-4057qib7 14637 10 procedure procedure NN cord-005453-4057qib7 14637 11 performed perform VBN cord-005453-4057qib7 14637 12 in in IN cord-005453-4057qib7 14637 13 our -PRON- PRP$ cord-005453-4057qib7 14637 14 center center NN cord-005453-4057qib7 14637 15 between between IN cord-005453-4057qib7 14637 16 2006 2006 CD cord-005453-4057qib7 14637 17 and and CC cord-005453-4057qib7 14637 18 2016 2016 CD cord-005453-4057qib7 14637 19 for for IN cord-005453-4057qib7 14637 20 MM MM NNP cord-005453-4057qib7 14637 21 . . . cord-005453-4057qib7 14638 1 All all DT cord-005453-4057qib7 14638 2 received receive VBD cord-005453-4057qib7 14638 3 the the DT cord-005453-4057qib7 14638 4 same same JJ cord-005453-4057qib7 14638 5 mobilization mobilization NN cord-005453-4057qib7 14638 6 protocol protocol NN cord-005453-4057qib7 14638 7 with with IN cord-005453-4057qib7 14638 8 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14638 9 ( ( -LRB- cord-005453-4057qib7 14638 10 range range NNP cord-005453-4057qib7 14638 11 3 3 CD cord-005453-4057qib7 14638 12 - - SYM cord-005453-4057qib7 14638 13 4 4 CD cord-005453-4057qib7 14638 14 gr gr NNP cord-005453-4057qib7 14638 15 / / SYM cord-005453-4057qib7 14638 16 sqm sqm NNP cord-005453-4057qib7 14638 17 ) ) -RRB- cord-005453-4057qib7 14638 18 and and CC cord-005453-4057qib7 14638 19 G G NNP cord-005453-4057qib7 14638 20 - - HYPH cord-005453-4057qib7 14638 21 CSF CSF NNP cord-005453-4057qib7 14638 22 10mcg 10mcg NNP cord-005453-4057qib7 14638 23 / / SYM cord-005453-4057qib7 14638 24 kg kg NNS cord-005453-4057qib7 14638 25 from from IN cord-005453-4057qib7 14638 26 +5 +5 NN cord-005453-4057qib7 14638 27 . . . cord-005453-4057qib7 14639 1 CD34 CD34 NNP cord-005453-4057qib7 14639 2 + + CC cord-005453-4057qib7 14639 3 cell cell NN cord-005453-4057qib7 14639 4 count count NN cord-005453-4057qib7 14639 5 was be VBD cord-005453-4057qib7 14639 6 started start VBN cord-005453-4057qib7 14639 7 when when WRB cord-005453-4057qib7 14639 8 White White NNP cord-005453-4057qib7 14639 9 Blood Blood NNP cord-005453-4057qib7 14639 10 Cells Cells NNPS cord-005453-4057qib7 14639 11 ( ( -LRB- cord-005453-4057qib7 14639 12 WBC WBC NNP cord-005453-4057qib7 14639 13 ) ) -RRB- cord-005453-4057qib7 14639 14 count count NN cord-005453-4057qib7 14639 15 exceeded exceed VBD cord-005453-4057qib7 14639 16 1x10 1x10 CD cord-005453-4057qib7 14639 17 9 9 CD cord-005453-4057qib7 14640 1 /L. /L. NFP cord-005453-4057qib7 14640 2 Patients patient NNS cord-005453-4057qib7 14640 3 were be VBD cord-005453-4057qib7 14640 4 excluded exclude VBN cord-005453-4057qib7 14640 5 from from IN cord-005453-4057qib7 14640 6 this this DT cord-005453-4057qib7 14640 7 analysis analysis NN cord-005453-4057qib7 14640 8 if if IN cord-005453-4057qib7 14640 9 1 1 CD cord-005453-4057qib7 14640 10 ) ) -RRB- cord-005453-4057qib7 14640 11 showed show VBD cord-005453-4057qib7 14640 12 a a DT cord-005453-4057qib7 14640 13 CD34 CD34 NNP cord-005453-4057qib7 14640 14 + + CC cord-005453-4057qib7 14640 15 count count NN cord-005453-4057qib7 14640 16 > > XX cord-005453-4057qib7 14641 1 40 40 CD cord-005453-4057qib7 14641 2 / / SYM cord-005453-4057qib7 14641 3 mcL mcl NN cord-005453-4057qib7 14641 4 ( ( -LRB- cord-005453-4057qib7 14641 5 target target NN cord-005453-4057qib7 14641 6 achieved achieve VBN cord-005453-4057qib7 14641 7 at at IN cord-005453-4057qib7 14641 8 first first JJ cord-005453-4057qib7 14641 9 day day NN cord-005453-4057qib7 14641 10 count count NN cord-005453-4057qib7 14641 11 ) ) -RRB- cord-005453-4057qib7 14642 1 and/or and/or CC cord-005453-4057qib7 14643 1 2 2 LS cord-005453-4057qib7 14643 2 ) ) -RRB- cord-005453-4057qib7 14643 3 CD34 CD34 NNP cord-005453-4057qib7 14643 4 + + CC cord-005453-4057qib7 14643 5 count count NN cord-005453-4057qib7 14643 6 on on IN cord-005453-4057qib7 14643 7 second second JJ cord-005453-4057qib7 14643 8 day day NN cord-005453-4057qib7 14643 9 was be VBD cord-005453-4057qib7 14643 10 missing miss VBG cord-005453-4057qib7 14643 11 and/or and/or CC cord-005453-4057qib7 14644 1 3 3 LS cord-005453-4057qib7 14644 2 ) ) -RRB- cord-005453-4057qib7 14645 1 Plerixafor Plerixafor NNP cord-005453-4057qib7 14645 2 was be VBD cord-005453-4057qib7 14645 3 administered administer VBN cord-005453-4057qib7 14645 4 on on IN cord-005453-4057qib7 14645 5 first first JJ cord-005453-4057qib7 14645 6 day day NN cord-005453-4057qib7 14645 7 according accord VBG cord-005453-4057qib7 14645 8 to to IN cord-005453-4057qib7 14645 9 previous previous JJ cord-005453-4057qib7 14645 10 policies policy NNS cord-005453-4057qib7 14645 11 . . . cord-005453-4057qib7 14646 1 Sixty sixty CD cord-005453-4057qib7 14646 2 - - HYPH cord-005453-4057qib7 14646 3 eight eight CD cord-005453-4057qib7 14646 4 patients patient NNS cord-005453-4057qib7 14646 5 were be VBD cord-005453-4057qib7 14646 6 evaluable evaluable JJ cord-005453-4057qib7 14646 7 for for IN cord-005453-4057qib7 14646 8 the the DT cord-005453-4057qib7 14646 9 study study NN cord-005453-4057qib7 14646 10 . . . cord-005453-4057qib7 14647 1 Univariate univariate JJ cord-005453-4057qib7 14647 2 and and CC cord-005453-4057qib7 14647 3 multivariate multivariate JJ cord-005453-4057qib7 14647 4 logistic logistic JJ cord-005453-4057qib7 14647 5 regression regression NN cord-005453-4057qib7 14647 6 analysis analysis NN cord-005453-4057qib7 14647 7 to to TO cord-005453-4057qib7 14647 8 study study VB cord-005453-4057qib7 14647 9 cCD34 cCD34 NNP cord-005453-4057qib7 14648 1 + + CC cord-005453-4057qib7 14648 2 kinetics kinetic NNS cord-005453-4057qib7 14648 3 and and CC cord-005453-4057qib7 14648 4 assess assess VB cord-005453-4057qib7 14648 5 predictors predictors JJ cord-005453-4057qib7 14648 6 impact impact NN cord-005453-4057qib7 14648 7 on on IN cord-005453-4057qib7 14648 8 mobilization mobilization NN cord-005453-4057qib7 14648 9 was be VBD cord-005453-4057qib7 14648 10 carried carry VBN cord-005453-4057qib7 14648 11 out out RP cord-005453-4057qib7 14648 12 . . . cord-005453-4057qib7 14649 1 Ratio ratio NN cord-005453-4057qib7 14649 2 CD34 CD34 NNP cord-005453-4057qib7 14650 1 + + CC cord-005453-4057qib7 14651 1 /WBC /WBC . cord-005453-4057qib7 14652 1 in in IN cord-005453-4057qib7 14652 2 first first JJ cord-005453-4057qib7 14652 3 day day NN cord-005453-4057qib7 14652 4 count count NN cord-005453-4057qib7 14652 5 , , , cord-005453-4057qib7 14652 6 gender gender NN cord-005453-4057qib7 14652 7 , , , cord-005453-4057qib7 14652 8 disease disease NN cord-005453-4057qib7 14652 9 category category NN cord-005453-4057qib7 14652 10 and and CC cord-005453-4057qib7 14652 11 time time NN cord-005453-4057qib7 14652 12 from from IN cord-005453-4057qib7 14652 13 mobilization mobilization NN cord-005453-4057qib7 14652 14 chemotherapy chemotherapy NN cord-005453-4057qib7 14652 15 were be VBD cord-005453-4057qib7 14652 16 also also RB cord-005453-4057qib7 14652 17 included include VBN cord-005453-4057qib7 14652 18 Results result NNS cord-005453-4057qib7 14652 19 : : : cord-005453-4057qib7 14653 1 Among among IN cord-005453-4057qib7 14653 2 the the DT cord-005453-4057qib7 14653 3 68 68 CD cord-005453-4057qib7 14653 4 patients patient NNS cord-005453-4057qib7 14653 5 included include VBN cord-005453-4057qib7 14653 6 in in IN cord-005453-4057qib7 14653 7 the the DT cord-005453-4057qib7 14653 8 analysis analysis NN cord-005453-4057qib7 14653 9 , , , cord-005453-4057qib7 14653 10 the the DT cord-005453-4057qib7 14653 11 threshold threshold NN cord-005453-4057qib7 14653 12 of of IN cord-005453-4057qib7 14653 13 40 40 CD cord-005453-4057qib7 14653 14 CD34+/mcL CD34+/mcL NNP cord-005453-4057qib7 14653 15 cells cell NNS cord-005453-4057qib7 14653 16 on on IN cord-005453-4057qib7 14653 17 the the DT cord-005453-4057qib7 14653 18 second second JJ cord-005453-4057qib7 14653 19 day day NN cord-005453-4057qib7 14653 20 was be VBD cord-005453-4057qib7 14653 21 reached reach VBN cord-005453-4057qib7 14653 22 by by IN cord-005453-4057qib7 14653 23 35 35 CD cord-005453-4057qib7 14653 24 ( ( -LRB- cord-005453-4057qib7 14653 25 51,47 51,47 CD cord-005453-4057qib7 14653 26 % % NN cord-005453-4057qib7 14653 27 ) ) -RRB- cord-005453-4057qib7 14653 28 of of IN cord-005453-4057qib7 14653 29 patients patient NNS cord-005453-4057qib7 14653 30 ( ( -LRB- cord-005453-4057qib7 14653 31 GroupA groupa VB cord-005453-4057qib7 14653 32 ) ) -RRB- cord-005453-4057qib7 14653 33 whilst whilst IN cord-005453-4057qib7 14653 34 the the DT cord-005453-4057qib7 14653 35 remaining remain VBG cord-005453-4057qib7 14653 36 33 33 CD cord-005453-4057qib7 14653 37 ( ( -LRB- cord-005453-4057qib7 14653 38 24,7 24,7 CD cord-005453-4057qib7 14653 39 % % NN cord-005453-4057qib7 14653 40 ) ) -RRB- cord-005453-4057qib7 14653 41 failed fail VBD cord-005453-4057qib7 14653 42 the the DT cord-005453-4057qib7 14653 43 target target NN cord-005453-4057qib7 14653 44 ( ( -LRB- cord-005453-4057qib7 14653 45 GroupB groupb NN cord-005453-4057qib7 14653 46 ) ) -RRB- cord-005453-4057qib7 14653 47 . . . cord-005453-4057qib7 14654 1 Median median JJ cord-005453-4057qib7 14654 2 ( ( -LRB- cord-005453-4057qib7 14654 3 range range NN cord-005453-4057qib7 14654 4 ) ) -RRB- cord-005453-4057qib7 14655 1 WBC WBC NNP cord-005453-4057qib7 14655 2 x10 x10 NNP cord-005453-4057qib7 14655 3 9 9 CD cord-005453-4057qib7 14655 4 /L /L , cord-005453-4057qib7 14655 5 and and CC cord-005453-4057qib7 14655 6 CD34 CD34 NNP cord-005453-4057qib7 14655 7 + + CC cord-005453-4057qib7 14655 8 /mcL /mcL NNP cord-005453-4057qib7 14655 9 counts count NNS cord-005453-4057qib7 14655 10 in in IN cord-005453-4057qib7 14655 11 group group NN cord-005453-4057qib7 14655 12 A a NN cord-005453-4057qib7 14655 13 and and CC cord-005453-4057qib7 14655 14 B B NNP cord-005453-4057qib7 14655 15 were be VBD cord-005453-4057qib7 14655 16 2,01 2,01 CD cord-005453-4057qib7 14655 17 ( ( -LRB- cord-005453-4057qib7 14655 18 1 1 CD cord-005453-4057qib7 14655 19 - - SYM cord-005453-4057qib7 14655 20 5,01 5,01 CD cord-005453-4057qib7 14655 21 ) ) -RRB- cord-005453-4057qib7 14655 22 and and CC cord-005453-4057qib7 14655 23 21,33 21,33 CD cord-005453-4057qib7 14655 24 ( ( -LRB- cord-005453-4057qib7 14655 25 7,56 7,56 CD cord-005453-4057qib7 14655 26 -39,91 -39,91 ADD cord-005453-4057qib7 14655 27 ) ) -RRB- cord-005453-4057qib7 14655 28 , , , cord-005453-4057qib7 14655 29 1,08 1,08 CD cord-005453-4057qib7 14655 30 ( ( -LRB- cord-005453-4057qib7 14655 31 1 1 CD cord-005453-4057qib7 14655 32 ) ) -RRB- cord-005453-4057qib7 14655 33 ( ( -LRB- cord-005453-4057qib7 14655 34 2 2 LS cord-005453-4057qib7 14655 35 ) ) -RRB- cord-005453-4057qib7 14656 1 ( ( -LRB- cord-005453-4057qib7 14656 2 3 3 LS cord-005453-4057qib7 14656 3 ) ) -RRB- cord-005453-4057qib7 14656 4 ( ( -LRB- cord-005453-4057qib7 14656 5 4 4 LS cord-005453-4057qib7 14656 6 ) ) -RRB- cord-005453-4057qib7 14656 7 ( ( -LRB- cord-005453-4057qib7 14656 8 5 5 LS cord-005453-4057qib7 14656 9 ) ) -RRB- cord-005453-4057qib7 14656 10 ( ( -LRB- cord-005453-4057qib7 14656 11 6 6 CD cord-005453-4057qib7 14656 12 ) ) -RRB- cord-005453-4057qib7 14656 13 46 46 CD cord-005453-4057qib7 14656 14 ) ) -RRB- cord-005453-4057qib7 14656 15 and and CC cord-005453-4057qib7 14656 16 3,31 3,31 NN cord-005453-4057qib7 14656 17 ( ( -LRB- cord-005453-4057qib7 14656 18 0,06 0,06 NN cord-005453-4057qib7 14656 19 - - HYPH cord-005453-4057qib7 14656 20 31,14 31,14 CD cord-005453-4057qib7 14656 21 ) ) -RRB- cord-005453-4057qib7 14656 22 respectively respectively RB cord-005453-4057qib7 14656 23 , , , cord-005453-4057qib7 14656 24 with with IN cord-005453-4057qib7 14656 25 a a DT cord-005453-4057qib7 14656 26 statistically statistically RB cord-005453-4057qib7 14656 27 significant significant JJ cord-005453-4057qib7 14656 28 differences difference NNS cord-005453-4057qib7 14656 29 among among IN cord-005453-4057qib7 14656 30 group group NN cord-005453-4057qib7 14656 31 ( ( -LRB- cord-005453-4057qib7 14656 32 Mann Mann NNP cord-005453-4057qib7 14656 33 - - HYPH cord-005453-4057qib7 14656 34 Whitney Whitney NNP cord-005453-4057qib7 14656 35 p= p= NNP cord-005453-4057qib7 14656 36 0,01 0,01 NN cord-005453-4057qib7 14656 37 and and CC cord-005453-4057qib7 14656 38 p=0,02 p=0,02 MD cord-005453-4057qib7 14656 39 respectively respectively RB cord-005453-4057qib7 14656 40 ) ) -RRB- cord-005453-4057qib7 14656 41 . . . cord-005453-4057qib7 14657 1 Only only RB cord-005453-4057qib7 14657 2 CD34 CD34 NNP cord-005453-4057qib7 14657 3 + + CC cord-005453-4057qib7 14658 1 /WBC /WBC NNP cord-005453-4057qib7 14658 2 ratio ratio NN cord-005453-4057qib7 14658 3 and and CC cord-005453-4057qib7 14658 4 CD34 CD34 NNP cord-005453-4057qib7 14659 1 + + CC cord-005453-4057qib7 14660 1 /mcL /mcL . cord-005453-4057qib7 14661 1 on on IN cord-005453-4057qib7 14661 2 first first JJ cord-005453-4057qib7 14661 3 day day NN cord-005453-4057qib7 14661 4 count count NN cord-005453-4057qib7 14661 5 had have VBD cord-005453-4057qib7 14661 6 an an DT cord-005453-4057qib7 14661 7 impact impact NN cord-005453-4057qib7 14661 8 on on IN cord-005453-4057qib7 14661 9 kinetics kinetic NNS cord-005453-4057qib7 14661 10 and and CC cord-005453-4057qib7 14661 11 optimal optimal JJ cord-005453-4057qib7 14661 12 mobilization mobilization NN cord-005453-4057qib7 14661 13 . . . cord-005453-4057qib7 14662 1 Logistic logistic JJ cord-005453-4057qib7 14662 2 regression regression NN cord-005453-4057qib7 14662 3 model model NN cord-005453-4057qib7 14662 4 highlight highlight NN cord-005453-4057qib7 14662 5 CD34+/mcL cd34+/mcl XX cord-005453-4057qib7 14663 1 ( ( -LRB- cord-005453-4057qib7 14663 2 OR=1,270 OR=1,270 NNP cord-005453-4057qib7 14664 1 ; ; : cord-005453-4057qib7 14664 2 95 95 CD cord-005453-4057qib7 14664 3 % % NN cord-005453-4057qib7 14664 4 CI ci NN cord-005453-4057qib7 14664 5 : : : cord-005453-4057qib7 14664 6 1,060 1,060 CD cord-005453-4057qib7 14664 7 -1,522 -1,522 NN cord-005453-4057qib7 14664 8 ) ) -RRB- cord-005453-4057qib7 14664 9 on on IN cord-005453-4057qib7 14664 10 first first JJ cord-005453-4057qib7 14664 11 count count NN cord-005453-4057qib7 14664 12 as as IN cord-005453-4057qib7 14664 13 an an DT cord-005453-4057qib7 14664 14 independent independent JJ cord-005453-4057qib7 14664 15 predictor predictor NN cord-005453-4057qib7 14664 16 of of IN cord-005453-4057qib7 14664 17 second second JJ cord-005453-4057qib7 14664 18 day day NN cord-005453-4057qib7 14664 19 optimal optimal JJ cord-005453-4057qib7 14664 20 mobilizer mobilizer NN cord-005453-4057qib7 14664 21 , , , cord-005453-4057qib7 14664 22 with with IN cord-005453-4057qib7 14664 23 AUC AUC NNP cord-005453-4057qib7 14664 24 of of IN cord-005453-4057qib7 14664 25 0.9 0.9 CD cord-005453-4057qib7 14664 26 % % NN cord-005453-4057qib7 14664 27 ( ( -LRB- cord-005453-4057qib7 14664 28 0 0 CD cord-005453-4057qib7 14664 29 , , , cord-005453-4057qib7 14664 30 99 99 CD cord-005453-4057qib7 14664 31 ) ) -RRB- cord-005453-4057qib7 14664 32 in in IN cord-005453-4057qib7 14664 33 ROC ROC NNP cord-005453-4057qib7 14664 34 analysis analysis NN cord-005453-4057qib7 14664 35 . . . cord-005453-4057qib7 14665 1 Two two CD cord-005453-4057qib7 14665 2 CD34 CD34 NNP cord-005453-4057qib7 14665 3 + + CC cord-005453-4057qib7 14665 4 thresholds threshold NNS cord-005453-4057qib7 14665 5 were be VBD cord-005453-4057qib7 14665 6 then then RB cord-005453-4057qib7 14665 7 calculated calculate VBN cord-005453-4057qib7 14665 8 : : : cord-005453-4057qib7 14666 1 < < XX cord-005453-4057qib7 14666 2 7,56 7,56 NNP cord-005453-4057qib7 14666 3 / / SYM cord-005453-4057qib7 14666 4 mcl mcl NNP cord-005453-4057qib7 14666 5 ( ( -LRB- cord-005453-4057qib7 14666 6 PPV PPV NNP cord-005453-4057qib7 14666 7 0,81 0,81 CD cord-005453-4057qib7 14666 8 ; ; : cord-005453-4057qib7 14666 9 NPV NPV NNP cord-005453-4057qib7 14666 10 1,0 1,0 CD cord-005453-4057qib7 14666 11 ) ) -RRB- cord-005453-4057qib7 14666 12 that that WDT cord-005453-4057qib7 14666 13 identified identify VBD cord-005453-4057qib7 14666 14 poor poor JJ cord-005453-4057qib7 14666 15 mobilizer mobilizer NN cord-005453-4057qib7 14666 16 , , , cord-005453-4057qib7 14666 17 and and CC cord-005453-4057qib7 14666 18 ≥ ≥ CD cord-005453-4057qib7 14666 19 24,06 24,06 CD cord-005453-4057qib7 14666 20 / / SYM cord-005453-4057qib7 14666 21 mcl mcl NNP cord-005453-4057qib7 14666 22 ( ( -LRB- cord-005453-4057qib7 14666 23 PPV PPV NNP cord-005453-4057qib7 14666 24 1,0 1,0 CD cord-005453-4057qib7 14666 25 ; ; : cord-005453-4057qib7 14667 1 NPV0,59 NPV0,59 NNP cord-005453-4057qib7 14667 2 ) ) -RRB- cord-005453-4057qib7 14667 3 that that WDT cord-005453-4057qib7 14667 4 exclude exclude VBP cord-005453-4057qib7 14667 5 probability probability NN cord-005453-4057qib7 14667 6 to to TO cord-005453-4057qib7 14667 7 fail fail VB cord-005453-4057qib7 14667 8 on on IN cord-005453-4057qib7 14667 9 second second JJ cord-005453-4057qib7 14667 10 day day NN cord-005453-4057qib7 14667 11 . . . cord-005453-4057qib7 14668 1 For for IN cord-005453-4057qib7 14668 2 those those DT cord-005453-4057qib7 14668 3 with with IN cord-005453-4057qib7 14668 4 a a DT cord-005453-4057qib7 14668 5 CD34 CD34 NNP cord-005453-4057qib7 14668 6 + + CC cord-005453-4057qib7 14668 7 count count NN cord-005453-4057qib7 14668 8 between between IN cord-005453-4057qib7 14668 9 7,56 7,56 CD cord-005453-4057qib7 14668 10 - - HYPH cord-005453-4057qib7 14668 11 24,06 24,06 CD cord-005453-4057qib7 14668 12 the the DT cord-005453-4057qib7 14668 13 CD34+/WBC CD34+/WBC NNP cord-005453-4057qib7 14668 14 ratio ratio NN cord-005453-4057qib7 14668 15 ( ( -LRB- cord-005453-4057qib7 14668 16 OR=1,768 or=1,768 NN cord-005453-4057qib7 14668 17 , , , cord-005453-4057qib7 14668 18 95 95 CD cord-005453-4057qib7 14668 19 % % NN cord-005453-4057qib7 14668 20 CI ci NN cord-005453-4057qib7 14668 21 : : : cord-005453-4057qib7 14668 22 1,307 1,307 CD cord-005453-4057qib7 14668 23 - - SYM cord-005453-4057qib7 14668 24 2,391 2,391 CD cord-005453-4057qib7 14668 25 ) ) -RRB- cord-005453-4057qib7 14668 26 was be VBD cord-005453-4057qib7 14668 27 a a DT cord-005453-4057qib7 14668 28 predictor predictor NN cord-005453-4057qib7 14668 29 of of IN cord-005453-4057qib7 14668 30 optimal optimal JJ cord-005453-4057qib7 14668 31 mobilization mobilization NN cord-005453-4057qib7 14668 32 ( ( -LRB- cord-005453-4057qib7 14668 33 AUC AUC NNP cord-005453-4057qib7 14668 34 0,94 0,94 NNP cord-005453-4057qib7 14668 35 ; ; : cord-005453-4057qib7 14668 36 0,885 0,885 CD cord-005453-4057qib7 14668 37 - - SYM cord-005453-4057qib7 14668 38 0,996 0,996 CD cord-005453-4057qib7 14668 39 ) ) -RRB- cord-005453-4057qib7 14668 40 ; ; : cord-005453-4057qib7 14668 41 cut cut VB cord-005453-4057qib7 14668 42 - - HYPH cord-005453-4057qib7 14668 43 off off RP cord-005453-4057qib7 14668 44 value value NN cord-005453-4057qib7 14668 45 was be VBD cord-005453-4057qib7 14668 46 5,63 5,63 CD cord-005453-4057qib7 14668 47 ( ( -LRB- cord-005453-4057qib7 14668 48 sensibility sensibility NN cord-005453-4057qib7 14668 49 94,28 94,28 CD cord-005453-4057qib7 14668 50 ; ; : cord-005453-4057qib7 14668 51 specificity specificity NN cord-005453-4057qib7 14668 52 84,84 84,84 CD cord-005453-4057qib7 14668 53 ) ) -RRB- cord-005453-4057qib7 14669 1 Conclusions conclusion NNS cord-005453-4057qib7 14669 2 : : : cord-005453-4057qib7 14670 1 Assessment assessment NN cord-005453-4057qib7 14670 2 of of IN cord-005453-4057qib7 14670 3 circulating circulate VBG cord-005453-4057qib7 14670 4 WBC WBC NNP cord-005453-4057qib7 14670 5 , , , cord-005453-4057qib7 14670 6 CD34 CD34 NNP cord-005453-4057qib7 14670 7 + + CC cord-005453-4057qib7 14670 8 and and CC cord-005453-4057qib7 14670 9 their -PRON- PRP$ cord-005453-4057qib7 14670 10 ratio ratio NN cord-005453-4057qib7 14670 11 at at IN cord-005453-4057qib7 14670 12 WBC WBC NNP cord-005453-4057qib7 14670 13 recovery recovery NN cord-005453-4057qib7 14670 14 in in IN cord-005453-4057qib7 14670 15 a a DT cord-005453-4057qib7 14670 16 chemo chemo NN cord-005453-4057qib7 14670 17 - - HYPH cord-005453-4057qib7 14670 18 based base VBN cord-005453-4057qib7 14670 19 mobilization mobilization NN cord-005453-4057qib7 14670 20 is be VBZ cord-005453-4057qib7 14670 21 a a DT cord-005453-4057qib7 14670 22 valid valid JJ cord-005453-4057qib7 14670 23 tool tool NN cord-005453-4057qib7 14670 24 to to TO cord-005453-4057qib7 14670 25 manage manage VB cord-005453-4057qib7 14670 26 the the DT cord-005453-4057qib7 14670 27 collection collection NN cord-005453-4057qib7 14670 28 strategy strategy NN cord-005453-4057qib7 14670 29 and and CC cord-005453-4057qib7 14670 30 the the DT cord-005453-4057qib7 14670 31 on on IN cord-005453-4057qib7 14670 32 - - HYPH cord-005453-4057qib7 14670 33 demand demand NN cord-005453-4057qib7 14670 34 use use NN cord-005453-4057qib7 14670 35 of of IN cord-005453-4057qib7 14670 36 Plerixafor Plerixafor NNP cord-005453-4057qib7 14670 37 . . . cord-005453-4057qib7 14671 1 We -PRON- PRP cord-005453-4057qib7 14671 2 have have VBP cord-005453-4057qib7 14671 3 developed develop VBN cord-005453-4057qib7 14671 4 an an DT cord-005453-4057qib7 14671 5 algorithm algorithm NN cord-005453-4057qib7 14671 6 aimed aim VBN cord-005453-4057qib7 14671 7 to to IN cord-005453-4057qib7 14671 8 the the DT cord-005453-4057qib7 14671 9 use use NN cord-005453-4057qib7 14671 10 of of IN cord-005453-4057qib7 14671 11 Plerixafor Plerixafor NNP cord-005453-4057qib7 14671 12 to to IN cord-005453-4057qib7 14671 13 both both DT cord-005453-4057qib7 14671 14 rescue rescue VB cord-005453-4057qib7 14671 15 poor poor JJ cord-005453-4057qib7 14671 16 mobilizers mobilizer NNS cord-005453-4057qib7 14671 17 and and CC cord-005453-4057qib7 14671 18 boost boost VB cord-005453-4057qib7 14671 19 CD34 CD34 NNP cord-005453-4057qib7 14672 1 + + CC cord-005453-4057qib7 14672 2 count count NN cord-005453-4057qib7 14672 3 in in IN cord-005453-4057qib7 14672 4 intermediate intermediate JJ cord-005453-4057qib7 14672 5 mobilizers mobilizer NNS cord-005453-4057qib7 14672 6 . . . cord-005453-4057qib7 14673 1 Background background NN cord-005453-4057qib7 14673 2 : : : cord-005453-4057qib7 14674 1 Successful successful JJ cord-005453-4057qib7 14674 2 autologous autologous JJ cord-005453-4057qib7 14674 3 stem stem NN cord-005453-4057qib7 14674 4 cell cell NN cord-005453-4057qib7 14674 5 transplantation transplantation NN cord-005453-4057qib7 14674 6 ( ( -LRB- cord-005453-4057qib7 14674 7 ASCT ASCT NNP cord-005453-4057qib7 14674 8 ) ) -RRB- cord-005453-4057qib7 14674 9 requires require VBZ cord-005453-4057qib7 14674 10 the the DT cord-005453-4057qib7 14674 11 infusion infusion NN cord-005453-4057qib7 14674 12 of of IN cord-005453-4057qib7 14674 13 a a DT cord-005453-4057qib7 14674 14 sufficient sufficient JJ cord-005453-4057qib7 14674 15 number number NN cord-005453-4057qib7 14674 16 of of IN cord-005453-4057qib7 14674 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 14674 18 stem stem NN cord-005453-4057qib7 14674 19 cells cell NNS cord-005453-4057qib7 14674 20 ( ( -LRB- cord-005453-4057qib7 14674 21 HSCs HSCs NNP cord-005453-4057qib7 14674 22 ) ) -RRB- cord-005453-4057qib7 14674 23 . . . cord-005453-4057qib7 14675 1 Peripheral peripheral JJ cord-005453-4057qib7 14675 2 blood blood NN cord-005453-4057qib7 14675 3 ( ( -LRB- cord-005453-4057qib7 14675 4 PB PB NNP cord-005453-4057qib7 14675 5 ) ) -RRB- cord-005453-4057qib7 14675 6 is be VBZ cord-005453-4057qib7 14675 7 the the DT cord-005453-4057qib7 14675 8 most most RBS cord-005453-4057qib7 14675 9 commonly commonly RB cord-005453-4057qib7 14675 10 used use VBN cord-005453-4057qib7 14675 11 source source NN cord-005453-4057qib7 14675 12 of of IN cord-005453-4057qib7 14675 13 HSCs hscs NN cord-005453-4057qib7 14675 14 , , , cord-005453-4057qib7 14675 15 therefore therefore RB cord-005453-4057qib7 14675 16 , , , cord-005453-4057qib7 14675 17 it -PRON- PRP cord-005453-4057qib7 14675 18 is be VBZ cord-005453-4057qib7 14675 19 important important JJ cord-005453-4057qib7 14675 20 to to TO cord-005453-4057qib7 14675 21 optimize optimize VB cord-005453-4057qib7 14675 22 methods method NNS cord-005453-4057qib7 14675 23 used use VBN cord-005453-4057qib7 14675 24 to to TO cord-005453-4057qib7 14675 25 mobilize mobilize VB cord-005453-4057qib7 14675 26 the the DT cord-005453-4057qib7 14675 27 HSCs hscs NN cord-005453-4057qib7 14675 28 . . . cord-005453-4057qib7 14676 1 The the DT cord-005453-4057qib7 14676 2 most most RBS cord-005453-4057qib7 14676 3 clinically clinically RB cord-005453-4057qib7 14676 4 used use VBN cord-005453-4057qib7 14676 5 chemotherapeutic chemotherapeutic JJ cord-005453-4057qib7 14676 6 agents agent NNS cord-005453-4057qib7 14676 7 for for IN cord-005453-4057qib7 14676 8 effective effective JJ cord-005453-4057qib7 14676 9 mobilization mobilization NN cord-005453-4057qib7 14676 10 are be VBP cord-005453-4057qib7 14676 11 cyclophosphamide cyclophosphamide JJ cord-005453-4057qib7 14676 12 and and CC cord-005453-4057qib7 14676 13 etoposide etoposide RB cord-005453-4057qib7 14676 14 . . . cord-005453-4057qib7 14677 1 Recent recent JJ cord-005453-4057qib7 14677 2 published publish VBN cord-005453-4057qib7 14677 3 studies study NNS cord-005453-4057qib7 14677 4 suggest suggest VBP cord-005453-4057qib7 14677 5 that that IN cord-005453-4057qib7 14677 6 etoposide etoposide RB cord-005453-4057qib7 14677 7 has have VBZ cord-005453-4057qib7 14677 8 a a DT cord-005453-4057qib7 14677 9 better well JJR cord-005453-4057qib7 14677 10 mobilization mobilization NN cord-005453-4057qib7 14677 11 effect effect NN cord-005453-4057qib7 14677 12 than than IN cord-005453-4057qib7 14677 13 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 14677 14 even even RB cord-005453-4057qib7 14677 15 at at IN cord-005453-4057qib7 14677 16 lower low JJR cord-005453-4057qib7 14677 17 doses dose NNS cord-005453-4057qib7 14677 18 , , , cord-005453-4057qib7 14677 19 but but CC cord-005453-4057qib7 14677 20 it -PRON- PRP cord-005453-4057qib7 14677 21 is be VBZ cord-005453-4057qib7 14677 22 not not RB cord-005453-4057qib7 14677 23 clear clear JJ cord-005453-4057qib7 14677 24 why why WRB cord-005453-4057qib7 14677 25 this this DT cord-005453-4057qib7 14677 26 difference difference NN cord-005453-4057qib7 14677 27 occurs occur VBZ cord-005453-4057qib7 14677 28 . . . cord-005453-4057qib7 14678 1 In in IN cord-005453-4057qib7 14678 2 this this DT cord-005453-4057qib7 14678 3 study study NN cord-005453-4057qib7 14678 4 , , , cord-005453-4057qib7 14678 5 we -PRON- PRP cord-005453-4057qib7 14678 6 tried try VBD cord-005453-4057qib7 14678 7 to to TO cord-005453-4057qib7 14678 8 determine determine VB cord-005453-4057qib7 14678 9 whether whether IN cord-005453-4057qib7 14678 10 there there EX cord-005453-4057qib7 14678 11 is be VBZ cord-005453-4057qib7 14678 12 a a DT cord-005453-4057qib7 14678 13 difference difference NN cord-005453-4057qib7 14678 14 in in IN cord-005453-4057qib7 14678 15 the the DT cord-005453-4057qib7 14678 16 mechanism mechanism NN cord-005453-4057qib7 14678 17 of of IN cord-005453-4057qib7 14678 18 mobilization mobilization NN cord-005453-4057qib7 14678 19 between between IN cord-005453-4057qib7 14678 20 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14678 21 and and CC cord-005453-4057qib7 14678 22 etoposide etoposide RB cord-005453-4057qib7 14678 23 . . . cord-005453-4057qib7 14679 1 Methods method NNS cord-005453-4057qib7 14679 2 : : : cord-005453-4057qib7 14680 1 First first RB cord-005453-4057qib7 14680 2 , , , cord-005453-4057qib7 14680 3 in in IN cord-005453-4057qib7 14680 4 order order NN cord-005453-4057qib7 14680 5 to to TO cord-005453-4057qib7 14680 6 confirm confirm VB cord-005453-4057qib7 14680 7 the the DT cord-005453-4057qib7 14680 8 clinical clinical JJ cord-005453-4057qib7 14680 9 data datum NNS cord-005453-4057qib7 14680 10 for for IN cord-005453-4057qib7 14680 11 efficacy efficacy NN cord-005453-4057qib7 14680 12 and and CC cord-005453-4057qib7 14680 13 toxicity toxicity NN cord-005453-4057qib7 14680 14 of of IN cord-005453-4057qib7 14680 15 mobilization mobilization NN cord-005453-4057qib7 14680 16 , , , cord-005453-4057qib7 14680 17 we -PRON- PRP cord-005453-4057qib7 14680 18 retrospectively retrospectively RB cord-005453-4057qib7 14680 19 analyzed analyze VBD cord-005453-4057qib7 14680 20 the the DT cord-005453-4057qib7 14680 21 data datum NNS cord-005453-4057qib7 14680 22 of of IN cord-005453-4057qib7 14680 23 patients patient NNS cord-005453-4057qib7 14680 24 who who WP cord-005453-4057qib7 14680 25 were be VBD cord-005453-4057qib7 14680 26 diagnosed diagnose VBN cord-005453-4057qib7 14680 27 with with IN cord-005453-4057qib7 14680 28 lymphoma lymphoma NN cord-005453-4057qib7 14680 29 and and CC cord-005453-4057qib7 14680 30 performed perform VBN cord-005453-4057qib7 14680 31 mobilization mobilization NN cord-005453-4057qib7 14680 32 using use VBG cord-005453-4057qib7 14680 33 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 14680 34 or or CC cord-005453-4057qib7 14680 35 etoposide etoposide RB cord-005453-4057qib7 14680 36 from from IN cord-005453-4057qib7 14680 37 January January NNP cord-005453-4057qib7 14680 38 2011 2011 CD cord-005453-4057qib7 14680 39 to to IN cord-005453-4057qib7 14680 40 December December NNP cord-005453-4057qib7 14680 41 2018 2018 CD cord-005453-4057qib7 14680 42 . . . cord-005453-4057qib7 14681 1 Second second RB cord-005453-4057qib7 14681 2 , , , cord-005453-4057qib7 14681 3 mesenchymal mesenchymal JJ cord-005453-4057qib7 14681 4 stem stem NN cord-005453-4057qib7 14681 5 cells cell NNS cord-005453-4057qib7 14681 6 ( ( -LRB- cord-005453-4057qib7 14681 7 MSC MSC NNP cord-005453-4057qib7 14681 8 ) ) -RRB- cord-005453-4057qib7 14681 9 were be VBD cord-005453-4057qib7 14681 10 primarily primarily RB cord-005453-4057qib7 14681 11 cultured culture VBN cord-005453-4057qib7 14681 12 from from IN cord-005453-4057qib7 14681 13 the the DT cord-005453-4057qib7 14681 14 healthy healthy JJ cord-005453-4057qib7 14681 15 controls control NNS cord-005453-4057qib7 14681 16 , , , cord-005453-4057qib7 14681 17 then then RB cord-005453-4057qib7 14681 18 treated treat VBN cord-005453-4057qib7 14681 19 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14681 20 or or CC cord-005453-4057qib7 14681 21 etoposide etoposide VBD cord-005453-4057qib7 14681 22 at at IN cord-005453-4057qib7 14681 23 a a DT cord-005453-4057qib7 14681 24 concentration concentration NN cord-005453-4057qib7 14681 25 of of IN cord-005453-4057qib7 14681 26 10 10 CD cord-005453-4057qib7 14681 27 % % NN cord-005453-4057qib7 14681 28 inhibition inhibition NN cord-005453-4057qib7 14681 29 of of IN cord-005453-4057qib7 14681 30 cell cell NN cord-005453-4057qib7 14681 31 growth growth NN cord-005453-4057qib7 14681 32 , , , cord-005453-4057qib7 14681 33 and and CC cord-005453-4057qib7 14681 34 cytokine cytokine NN cord-005453-4057qib7 14681 35 analysis analysis NN cord-005453-4057qib7 14681 36 was be VBD cord-005453-4057qib7 14681 37 performed perform VBN cord-005453-4057qib7 14681 38 to to TO cord-005453-4057qib7 14681 39 identify identify VB cord-005453-4057qib7 14681 40 cytokines cytokine NNS cord-005453-4057qib7 14681 41 known know VBN cord-005453-4057qib7 14681 42 to to TO cord-005453-4057qib7 14681 43 be be VB cord-005453-4057qib7 14681 44 associated associate VBN cord-005453-4057qib7 14681 45 with with IN cord-005453-4057qib7 14681 46 mobilization mobilization NN cord-005453-4057qib7 14681 47 . . . cord-005453-4057qib7 14682 1 Third third JJ cord-005453-4057qib7 14682 2 , , , cord-005453-4057qib7 14682 3 mobilization mobilization NN cord-005453-4057qib7 14682 4 mouse mouse NN cord-005453-4057qib7 14682 5 model model NN cord-005453-4057qib7 14682 6 using use VBG cord-005453-4057qib7 14682 7 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 14682 8 or or CC cord-005453-4057qib7 14682 9 etoposide etoposide NN cord-005453-4057qib7 14682 10 was be VBD cord-005453-4057qib7 14682 11 generated generate VBN cord-005453-4057qib7 14682 12 , , , cord-005453-4057qib7 14682 13 total total JJ cord-005453-4057qib7 14682 14 blood blood NN cord-005453-4057qib7 14682 15 was be VBD cord-005453-4057qib7 14682 16 collected collect VBN cord-005453-4057qib7 14682 17 at at IN cord-005453-4057qib7 14682 18 the the DT cord-005453-4057qib7 14682 19 time time NN cord-005453-4057qib7 14682 20 of of IN cord-005453-4057qib7 14682 21 HSCs hscs NN cord-005453-4057qib7 14682 22 collection collection NN cord-005453-4057qib7 14682 23 , , , cord-005453-4057qib7 14682 24 and and CC cord-005453-4057qib7 14682 25 cytokine cytokine NN cord-005453-4057qib7 14682 26 and and CC cord-005453-4057qib7 14682 27 network network NN cord-005453-4057qib7 14682 28 analysis analysis NN cord-005453-4057qib7 14682 29 ( ( -LRB- cord-005453-4057qib7 14682 30 using use VBG cord-005453-4057qib7 14682 31 Ingenuity Ingenuity NNP cord-005453-4057qib7 14682 32 Pathway Pathway NNP cord-005453-4057qib7 14682 33 Analysis Analysis NNP cord-005453-4057qib7 14682 34 ) ) -RRB- cord-005453-4057qib7 14682 35 was be VBD cord-005453-4057qib7 14682 36 performed perform VBN cord-005453-4057qib7 14682 37 . . . cord-005453-4057qib7 14683 1 Results result NNS cord-005453-4057qib7 14683 2 : : : cord-005453-4057qib7 14684 1 The the DT cord-005453-4057qib7 14684 2 mobilization mobilization NN cord-005453-4057qib7 14684 3 yields yield VBZ cord-005453-4057qib7 14684 4 for for IN cord-005453-4057qib7 14684 5 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14684 6 or or CC cord-005453-4057qib7 14684 7 etoposide etoposide JJ cord-005453-4057qib7 14684 8 were be VBD cord-005453-4057qib7 14684 9 analyzed analyze VBN cord-005453-4057qib7 14684 10 . . . cord-005453-4057qib7 14685 1 Etoposide Etoposide NNP cord-005453-4057qib7 14685 2 miblized miblize VBD cord-005453-4057qib7 14685 3 a a DT cord-005453-4057qib7 14685 4 significantly significantly RB cord-005453-4057qib7 14685 5 higher high JJR cord-005453-4057qib7 14685 6 median median JJ cord-005453-4057qib7 14685 7 number number NN cord-005453-4057qib7 14685 8 of of IN cord-005453-4057qib7 14685 9 CD34+cells CD34+cells NNPS cord-005453-4057qib7 14685 10 than than IN cord-005453-4057qib7 14685 11 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 14685 12 . . . cord-005453-4057qib7 14686 1 The the DT cord-005453-4057qib7 14686 2 rate rate NN cord-005453-4057qib7 14686 3 of of IN cord-005453-4057qib7 14686 4 successful successful JJ cord-005453-4057qib7 14686 5 or or CC cord-005453-4057qib7 14686 6 adequate adequate JJ cord-005453-4057qib7 14686 7 mobilization mobilization NN cord-005453-4057qib7 14686 8 was be VBD cord-005453-4057qib7 14686 9 also also RB cord-005453-4057qib7 14686 10 significanctly significanctly RB cord-005453-4057qib7 14686 11 higher high JJR cord-005453-4057qib7 14686 12 for for IN cord-005453-4057qib7 14686 13 etoposide etoposide JJ cord-005453-4057qib7 14686 14 in in IN cord-005453-4057qib7 14686 15 univariate univariate JJ cord-005453-4057qib7 14686 16 and and CC cord-005453-4057qib7 14686 17 multivariate multivariate JJ cord-005453-4057qib7 14686 18 analysis analysis NN cord-005453-4057qib7 14687 1 ( ( -LRB- cord-005453-4057qib7 14687 2 Table table NN cord-005453-4057qib7 14687 3 1 1 CD cord-005453-4057qib7 14687 4 ) ) -RRB- cord-005453-4057qib7 14687 5 . . . cord-005453-4057qib7 14688 1 In in IN cord-005453-4057qib7 14688 2 the the DT cord-005453-4057qib7 14688 3 analysis analysis NN cord-005453-4057qib7 14688 4 of of IN cord-005453-4057qib7 14688 5 toxicity toxicity NN cord-005453-4057qib7 14688 6 during during IN cord-005453-4057qib7 14688 7 mobilization mobilization NN cord-005453-4057qib7 14688 8 , , , cord-005453-4057qib7 14688 9 the the DT cord-005453-4057qib7 14688 10 incidence incidence NN cord-005453-4057qib7 14688 11 of of IN cord-005453-4057qib7 14688 12 neutropenic neutropenic JJ cord-005453-4057qib7 14688 13 fever fever NN cord-005453-4057qib7 14688 14 was be VBD cord-005453-4057qib7 14688 15 higher high JJR cord-005453-4057qib7 14688 16 in in IN cord-005453-4057qib7 14688 17 the the DT cord-005453-4057qib7 14688 18 cyclophosphamide cyclophosphamide JJ cord-005453-4057qib7 14688 19 group group NN cord-005453-4057qib7 14688 20 ( ( -LRB- cord-005453-4057qib7 14688 21 P p NN cord-005453-4057qib7 14688 22 = = SYM cord-005453-4057qib7 14688 23 0.007 0.007 CD cord-005453-4057qib7 14688 24 ) ) -RRB- cord-005453-4057qib7 14688 25 . . . cord-005453-4057qib7 14689 1 During during IN cord-005453-4057qib7 14689 2 mobilization mobilization NN cord-005453-4057qib7 14689 3 , , , cord-005453-4057qib7 14689 4 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 14689 5 maintained maintain VBD cord-005453-4057qib7 14689 6 lower low JJR cord-005453-4057qib7 14689 7 WBC WBC NNP cord-005453-4057qib7 14689 8 counts count NNS cord-005453-4057qib7 14689 9 than than IN cord-005453-4057qib7 14689 10 etoposide etoposide JJ cord-005453-4057qib7 14689 11 and and CC cord-005453-4057qib7 14689 12 showed show VBD cord-005453-4057qib7 14689 13 a a DT cord-005453-4057qib7 14689 14 large large JJ cord-005453-4057qib7 14689 15 increase increase NN cord-005453-4057qib7 14689 16 in in IN cord-005453-4057qib7 14689 17 WBC WBC NNP cord-005453-4057qib7 14689 18 counts count VBZ cord-005453-4057qib7 14689 19 at at IN cord-005453-4057qib7 14689 20 the the DT cord-005453-4057qib7 14689 21 start start NN cord-005453-4057qib7 14689 22 of of IN cord-005453-4057qib7 14689 23 collection collection NN cord-005453-4057qib7 14689 24 ( ( -LRB- cord-005453-4057qib7 14689 25 Figure figure NN cord-005453-4057qib7 14689 26 1 1 CD cord-005453-4057qib7 14689 27 ) ) -RRB- cord-005453-4057qib7 14689 28 . . . cord-005453-4057qib7 14690 1 The the DT cord-005453-4057qib7 14690 2 cumulative cumulative JJ cord-005453-4057qib7 14690 3 dose dose NN cord-005453-4057qib7 14690 4 of of IN cord-005453-4057qib7 14690 5 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14690 6 or or CC cord-005453-4057qib7 14690 7 etoposide etoposide VBN cord-005453-4057qib7 14690 8 in in IN cord-005453-4057qib7 14690 9 patients patient NNS cord-005453-4057qib7 14690 10 who who WP cord-005453-4057qib7 14690 11 underwent undergo VBD cord-005453-4057qib7 14690 12 autologous autologous JJ cord-005453-4057qib7 14690 13 stem stem NN cord-005453-4057qib7 14690 14 cell cell NN cord-005453-4057qib7 14690 15 transplantation transplantation NN cord-005453-4057qib7 14690 16 did do VBD cord-005453-4057qib7 14690 17 not not RB cord-005453-4057qib7 14690 18 affect affect VB cord-005453-4057qib7 14690 19 leukocyte leukocyte NN cord-005453-4057qib7 14690 20 ( ( -LRB- cord-005453-4057qib7 14690 21 ANC>1000 ANC>1000 NNP cord-005453-4057qib7 14690 22 / / SYM cord-005453-4057qib7 14690 23 microL microL NNP cord-005453-4057qib7 14690 24 or or CC cord-005453-4057qib7 14690 25 platelet platelet NN cord-005453-4057qib7 14691 1 ( ( -LRB- cord-005453-4057qib7 14691 2 PLT PLT NNP cord-005453-4057qib7 14691 3 > > XX cord-005453-4057qib7 14691 4 100k 100k CD cord-005453-4057qib7 14691 5 / / SYM cord-005453-4057qib7 14691 6 microL microL NNP cord-005453-4057qib7 14691 7 ) ) -RRB- cord-005453-4057qib7 14691 8 engraftment engraftment NN cord-005453-4057qib7 14691 9 . . . cord-005453-4057qib7 14692 1 In in IN cord-005453-4057qib7 14692 2 MSC MSC NNP cord-005453-4057qib7 14692 3 treated treat VBN cord-005453-4057qib7 14692 4 with with IN cord-005453-4057qib7 14692 5 etoposide etoposide JJ cord-005453-4057qib7 14692 6 at at IN cord-005453-4057qib7 14692 7 a a DT cord-005453-4057qib7 14692 8 concentration concentration NN cord-005453-4057qib7 14692 9 of of IN cord-005453-4057qib7 14692 10 10 10 CD cord-005453-4057qib7 14692 11 % % NN cord-005453-4057qib7 14692 12 inhibition inhibition NN cord-005453-4057qib7 14692 13 of of IN cord-005453-4057qib7 14692 14 cell cell NN cord-005453-4057qib7 14692 15 growth growth NN cord-005453-4057qib7 14692 16 , , , cord-005453-4057qib7 14692 17 IL-8 IL-8 NNP cord-005453-4057qib7 14692 18 , , , cord-005453-4057qib7 14692 19 which which WDT cord-005453-4057qib7 14692 20 is be VBZ cord-005453-4057qib7 14692 21 a a DT cord-005453-4057qib7 14692 22 cytokine cytokine NN cord-005453-4057qib7 14692 23 that that WDT cord-005453-4057qib7 14692 24 promotes promote VBZ cord-005453-4057qib7 14692 25 hematopoietic hematopoietic JJ cord-005453-4057qib7 14692 26 stem stem NN cord-005453-4057qib7 14692 27 cell cell NN cord-005453-4057qib7 14692 28 mobilization mobilization NN cord-005453-4057qib7 14692 29 , , , cord-005453-4057qib7 14692 30 were be VBD cord-005453-4057qib7 14692 31 shown show VBN cord-005453-4057qib7 14692 32 a a DT cord-005453-4057qib7 14692 33 statistically statistically RB cord-005453-4057qib7 14692 34 significant significant JJ cord-005453-4057qib7 14692 35 increase increase NN cord-005453-4057qib7 14692 36 ( ( -LRB- cord-005453-4057qib7 14692 37 Figure figure NN cord-005453-4057qib7 14692 38 2 2 CD cord-005453-4057qib7 14692 39 ) ) -RRB- cord-005453-4057qib7 14692 40 . . . cord-005453-4057qib7 14693 1 In in IN cord-005453-4057qib7 14693 2 the the DT cord-005453-4057qib7 14693 3 mouse mouse NN cord-005453-4057qib7 14693 4 model model NN cord-005453-4057qib7 14693 5 of of IN cord-005453-4057qib7 14693 6 mobilization mobilization NN cord-005453-4057qib7 14693 7 ( ( -LRB- cord-005453-4057qib7 14693 8 Figure figure NN cord-005453-4057qib7 14693 9 3 3 CD cord-005453-4057qib7 14693 10 ) ) -RRB- cord-005453-4057qib7 14693 11 , , , cord-005453-4057qib7 14693 12 the the DT cord-005453-4057qib7 14693 13 levels level NNS cord-005453-4057qib7 14693 14 of of IN cord-005453-4057qib7 14693 15 KC KC NNP cord-005453-4057qib7 14693 16 , , , cord-005453-4057qib7 14693 17 one one CD cord-005453-4057qib7 14693 18 of of IN cord-005453-4057qib7 14693 19 the the DT cord-005453-4057qib7 14693 20 IL-8 IL-8 NNP cord-005453-4057qib7 14693 21 homologues homologue NNS cord-005453-4057qib7 14693 22 in in IN cord-005453-4057qib7 14693 23 mice mouse NNS cord-005453-4057qib7 14693 24 , , , cord-005453-4057qib7 14693 25 had have VBD cord-005453-4057qib7 14693 26 significantly significantly RB cord-005453-4057qib7 14693 27 increased increase VBN cord-005453-4057qib7 14693 28 in in IN cord-005453-4057qib7 14693 29 the the DT cord-005453-4057qib7 14693 30 etoposide etoposide NN cord-005453-4057qib7 14693 31 - - HYPH cord-005453-4057qib7 14693 32 treated treat VBN cord-005453-4057qib7 14693 33 group group NN cord-005453-4057qib7 14693 34 compared compare VBN cord-005453-4057qib7 14693 35 with with IN cord-005453-4057qib7 14693 36 the the DT cord-005453-4057qib7 14693 37 levels level NNS cord-005453-4057qib7 14693 38 in in IN cord-005453-4057qib7 14693 39 the the DT cord-005453-4057qib7 14693 40 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14693 41 - - HYPH cord-005453-4057qib7 14693 42 treated treat VBN cord-005453-4057qib7 14693 43 group group NN cord-005453-4057qib7 14693 44 . . . cord-005453-4057qib7 14694 1 The the DT cord-005453-4057qib7 14694 2 levels level NNS cord-005453-4057qib7 14694 3 of of IN cord-005453-4057qib7 14694 4 other other JJ cord-005453-4057qib7 14694 5 IL-8 IL-8 NNP cord-005453-4057qib7 14694 6 homologues homologue NNS cord-005453-4057qib7 14694 7 , , , cord-005453-4057qib7 14694 8 MIP-2 MIP-2 NNP cord-005453-4057qib7 14694 9 and and CC cord-005453-4057qib7 14694 10 LIX LIX NNP cord-005453-4057qib7 14694 11 , , , cord-005453-4057qib7 14694 12 also also RB cord-005453-4057qib7 14694 13 showed show VBD cord-005453-4057qib7 14694 14 increases increase NNS cord-005453-4057qib7 14694 15 in in IN cord-005453-4057qib7 14694 16 the the DT cord-005453-4057qib7 14694 17 etoposide etoposide NN cord-005453-4057qib7 14694 18 - - HYPH cord-005453-4057qib7 14694 19 treated treat VBN cord-005453-4057qib7 14694 20 group group NN cord-005453-4057qib7 14694 21 compared compare VBN cord-005453-4057qib7 14694 22 with with IN cord-005453-4057qib7 14694 23 those those DT cord-005453-4057qib7 14694 24 in in IN cord-005453-4057qib7 14694 25 the the DT cord-005453-4057qib7 14694 26 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14694 27 - - HYPH cord-005453-4057qib7 14694 28 treated treat VBN cord-005453-4057qib7 14694 29 group group NN cord-005453-4057qib7 14694 30 ; ; : cord-005453-4057qib7 14694 31 these these DT cord-005453-4057qib7 14694 32 differences difference NNS cord-005453-4057qib7 14694 33 , , , cord-005453-4057qib7 14694 34 however however RB cord-005453-4057qib7 14694 35 , , , cord-005453-4057qib7 14694 36 were be VBD cord-005453-4057qib7 14694 37 not not RB cord-005453-4057qib7 14694 38 statistically statistically RB cord-005453-4057qib7 14694 39 significant significant JJ cord-005453-4057qib7 14695 1 ( ( -LRB- cord-005453-4057qib7 14695 2 Figure figure NN cord-005453-4057qib7 14695 3 4 4 CD cord-005453-4057qib7 14695 4 ) ) -RRB- cord-005453-4057qib7 14695 5 . . . cord-005453-4057qib7 14696 1 Network network NN cord-005453-4057qib7 14696 2 analysis analysis NN cord-005453-4057qib7 14696 3 based base VBN cord-005453-4057qib7 14696 4 on on IN cord-005453-4057qib7 14696 5 in in IN cord-005453-4057qib7 14696 6 vivo vivo NN cord-005453-4057qib7 14696 7 cytokine cytokine NN cord-005453-4057qib7 14696 8 results result NNS cord-005453-4057qib7 14696 9 identified identify VBN cord-005453-4057qib7 14696 10 that that IN cord-005453-4057qib7 14696 11 etoposide etoposide RB cord-005453-4057qib7 14696 12 could could MD cord-005453-4057qib7 14696 13 promote promote VB cord-005453-4057qib7 14696 14 mobilization mobilization NN cord-005453-4057qib7 14696 15 in in IN cord-005453-4057qib7 14696 16 association association NN cord-005453-4057qib7 14696 17 with with IN cord-005453-4057qib7 14696 18 matrix matrix NN cord-005453-4057qib7 14696 19 metalloproteinase metalloproteinase NN cord-005453-4057qib7 14696 20 as as IN cord-005453-4057qib7 14696 21 compared compare VBN cord-005453-4057qib7 14696 22 to to IN cord-005453-4057qib7 14696 23 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14696 24 ( ( -LRB- cord-005453-4057qib7 14696 25 Figure figure NN cord-005453-4057qib7 14696 26 5 5 CD cord-005453-4057qib7 14696 27 ) ) -RRB- cord-005453-4057qib7 14696 28 . . . cord-005453-4057qib7 14697 1 Conclusions conclusion NNS cord-005453-4057qib7 14697 2 : : : cord-005453-4057qib7 14698 1 Etoposide Etoposide NNP cord-005453-4057qib7 14698 2 has have VBZ cord-005453-4057qib7 14698 3 a a DT cord-005453-4057qib7 14698 4 higher high JJR cord-005453-4057qib7 14698 5 mobilization mobilization NN cord-005453-4057qib7 14698 6 efficacy efficacy NN cord-005453-4057qib7 14698 7 when when WRB cord-005453-4057qib7 14698 8 compared compare VBN cord-005453-4057qib7 14698 9 to to IN cord-005453-4057qib7 14698 10 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14698 11 , , , cord-005453-4057qib7 14698 12 which which WDT cord-005453-4057qib7 14698 13 could could MD cord-005453-4057qib7 14698 14 due due IN cord-005453-4057qib7 14698 15 to to IN cord-005453-4057qib7 14698 16 the the DT cord-005453-4057qib7 14698 17 different different JJ cord-005453-4057qib7 14698 18 mechanisms mechanism NNS cord-005453-4057qib7 14698 19 of of IN cord-005453-4057qib7 14698 20 mobilization mobilization NN cord-005453-4057qib7 14698 21 through through IN cord-005453-4057qib7 14698 22 the the DT cord-005453-4057qib7 14698 23 elevation elevation NN cord-005453-4057qib7 14698 24 of of IN cord-005453-4057qib7 14698 25 IL8 IL8 NNP cord-005453-4057qib7 14698 26 and and CC cord-005453-4057qib7 14698 27 the the DT cord-005453-4057qib7 14698 28 activation activation NN cord-005453-4057qib7 14698 29 of of IN cord-005453-4057qib7 14698 30 matrix matrix NN cord-005453-4057qib7 14698 31 metalloproteinase metalloproteinase NN cord-005453-4057qib7 14698 32 associated associate VBN cord-005453-4057qib7 14698 33 therewith therewith RB cord-005453-4057qib7 14698 34 . . . cord-005453-4057qib7 14699 1 Background background NN cord-005453-4057qib7 14699 2 : : : cord-005453-4057qib7 14700 1 High high JJ cord-005453-4057qib7 14700 2 - - HYPH cord-005453-4057qib7 14700 3 dose dose NN cord-005453-4057qib7 14700 4 chemotherapy chemotherapy NN cord-005453-4057qib7 14700 5 followed follow VBN cord-005453-4057qib7 14700 6 by by IN cord-005453-4057qib7 14700 7 autologous autologous JJ cord-005453-4057qib7 14700 8 blood blood NN cord-005453-4057qib7 14700 9 stem stem NN cord-005453-4057qib7 14700 10 cell cell NN cord-005453-4057qib7 14700 11 transplantation transplantation NN cord-005453-4057qib7 14700 12 ( ( -LRB- cord-005453-4057qib7 14700 13 ASCT ASCT NNP cord-005453-4057qib7 14700 14 ) ) -RRB- cord-005453-4057qib7 14700 15 is be VBZ cord-005453-4057qib7 14700 16 a a DT cord-005453-4057qib7 14700 17 standard standard JJ cord-005453-4057qib7 14700 18 therapy therapy NN cord-005453-4057qib7 14700 19 for for IN cord-005453-4057qib7 14700 20 wide wide JJ cord-005453-4057qib7 14700 21 range range NN cord-005453-4057qib7 14700 22 of of IN cord-005453-4057qib7 14700 23 hematologic hematologic JJ cord-005453-4057qib7 14700 24 and and CC cord-005453-4057qib7 14700 25 solid solid JJ cord-005453-4057qib7 14700 26 malignancies malignancy NNS cord-005453-4057qib7 14700 27 . . . cord-005453-4057qib7 14701 1 Although although IN cord-005453-4057qib7 14701 2 various various JJ cord-005453-4057qib7 14701 3 methods method NNS cord-005453-4057qib7 14701 4 have have VBP cord-005453-4057qib7 14701 5 been be VBN cord-005453-4057qib7 14701 6 introduced introduce VBN cord-005453-4057qib7 14701 7 to to TO cord-005453-4057qib7 14701 8 improve improve VB cord-005453-4057qib7 14701 9 the the DT cord-005453-4057qib7 14701 10 peripheral peripheral JJ cord-005453-4057qib7 14701 11 blood blood NN cord-005453-4057qib7 14701 12 stem stem NN cord-005453-4057qib7 14701 13 cell cell NN cord-005453-4057qib7 14701 14 ( ( -LRB- cord-005453-4057qib7 14701 15 PBSC PBSC NNP cord-005453-4057qib7 14701 16 ) ) -RRB- cord-005453-4057qib7 14701 17 mobilization mobilization NN cord-005453-4057qib7 14701 18 , , , cord-005453-4057qib7 14701 19 autologous autologous JJ cord-005453-4057qib7 14701 20 stem stem NN cord-005453-4057qib7 14701 21 cell cell NN cord-005453-4057qib7 14701 22 collection collection NN cord-005453-4057qib7 14701 23 ( ( -LRB- cord-005453-4057qib7 14701 24 ASCC ASCC NNP cord-005453-4057qib7 14701 25 ) ) -RRB- cord-005453-4057qib7 14701 26 is be VBZ cord-005453-4057qib7 14701 27 not not RB cord-005453-4057qib7 14701 28 successful successful JJ cord-005453-4057qib7 14701 29 in in IN cord-005453-4057qib7 14701 30 every every DT cord-005453-4057qib7 14701 31 patient patient NN cord-005453-4057qib7 14701 32 . . . cord-005453-4057qib7 14702 1 Furthermore furthermore RB cord-005453-4057qib7 14702 2 , , , cord-005453-4057qib7 14702 3 even even RB cord-005453-4057qib7 14702 4 if if IN cord-005453-4057qib7 14702 5 the the DT cord-005453-4057qib7 14702 6 ASCC ASCC NNP cord-005453-4057qib7 14702 7 is be VBZ cord-005453-4057qib7 14702 8 complete complete JJ cord-005453-4057qib7 14702 9 , , , cord-005453-4057qib7 14702 10 not not RB cord-005453-4057qib7 14702 11 all all DT cord-005453-4057qib7 14702 12 of of IN cord-005453-4057qib7 14702 13 them -PRON- PRP cord-005453-4057qib7 14702 14 lead lead VBP cord-005453-4057qib7 14702 15 to to IN cord-005453-4057qib7 14702 16 ASCT ASCT NNP cord-005453-4057qib7 14702 17 . . . cord-005453-4057qib7 14703 1 We -PRON- PRP cord-005453-4057qib7 14703 2 evaluated evaluate VBD cord-005453-4057qib7 14703 3 the the DT cord-005453-4057qib7 14703 4 result result NN cord-005453-4057qib7 14703 5 of of IN cord-005453-4057qib7 14703 6 ASCC ASCC NNP cord-005453-4057qib7 14703 7 and and CC cord-005453-4057qib7 14703 8 actual actual JJ cord-005453-4057qib7 14703 9 use use NN cord-005453-4057qib7 14703 10 of of IN cord-005453-4057qib7 14703 11 PBSC PBSC NNP cord-005453-4057qib7 14703 12 grafts graft NNS cord-005453-4057qib7 14703 13 in in IN cord-005453-4057qib7 14703 14 current current JJ cord-005453-4057qib7 14703 15 practical practical JJ cord-005453-4057qib7 14703 16 setting setting NN cord-005453-4057qib7 14703 17 . . . cord-005453-4057qib7 14704 1 Methods method NNS cord-005453-4057qib7 14704 2 : : : cord-005453-4057qib7 14704 3 We -PRON- PRP cord-005453-4057qib7 14704 4 retrospectively retrospectively RB cord-005453-4057qib7 14704 5 reviewed review VBD cord-005453-4057qib7 14704 6 the the DT cord-005453-4057qib7 14704 7 all all DT cord-005453-4057qib7 14704 8 consecutive consecutive JJ cord-005453-4057qib7 14704 9 ASCC ASCC NNP cord-005453-4057qib7 14704 10 procedures procedure NNS cord-005453-4057qib7 14704 11 performed perform VBN cord-005453-4057qib7 14704 12 at at IN cord-005453-4057qib7 14704 13 the the DT cord-005453-4057qib7 14704 14 Department Department NNP cord-005453-4057qib7 14704 15 of of IN cord-005453-4057qib7 14704 16 Oncology Oncology NNP cord-005453-4057qib7 14704 17 in in IN cord-005453-4057qib7 14704 18 Asan Asan NNP cord-005453-4057qib7 14704 19 Medical Medical NNP cord-005453-4057qib7 14704 20 Center Center NNP cord-005453-4057qib7 14704 21 , , , cord-005453-4057qib7 14704 22 Seoul Seoul NNP cord-005453-4057qib7 14704 23 , , , cord-005453-4057qib7 14704 24 Korea Korea NNP cord-005453-4057qib7 14704 25 , , , cord-005453-4057qib7 14704 26 between between IN cord-005453-4057qib7 14704 27 January January NNP cord-005453-4057qib7 14704 28 2000 2000 CD cord-005453-4057qib7 14704 29 and and CC cord-005453-4057qib7 14704 30 October October NNP cord-005453-4057qib7 14704 31 2018 2018 CD cord-005453-4057qib7 14704 32 . . . cord-005453-4057qib7 14705 1 The the DT cord-005453-4057qib7 14705 2 targeted target VBN cord-005453-4057qib7 14705 3 number number NN cord-005453-4057qib7 14705 4 of of IN cord-005453-4057qib7 14705 5 Background background NN cord-005453-4057qib7 14705 6 : : : cord-005453-4057qib7 14705 7 Fanconi Fanconi NNP cord-005453-4057qib7 14705 8 Anemia Anemia NNP cord-005453-4057qib7 14705 9 ( ( -LRB- cord-005453-4057qib7 14705 10 FA FA NNP cord-005453-4057qib7 14705 11 ) ) -RRB- cord-005453-4057qib7 14705 12 is be VBZ cord-005453-4057qib7 14705 13 a a DT cord-005453-4057qib7 14705 14 rare rare JJ cord-005453-4057qib7 14705 15 inherited inherit VBN cord-005453-4057qib7 14705 16 genetic genetic JJ cord-005453-4057qib7 14705 17 bone bone NN cord-005453-4057qib7 14705 18 marrow marrow NN cord-005453-4057qib7 14705 19 ( ( -LRB- cord-005453-4057qib7 14705 20 BM BM NNP cord-005453-4057qib7 14705 21 ) ) -RRB- cord-005453-4057qib7 14705 22 failure failure NN cord-005453-4057qib7 14705 23 syndrome syndrome NN cord-005453-4057qib7 14705 24 . . . cord-005453-4057qib7 14706 1 While while IN cord-005453-4057qib7 14706 2 abnormal abnormal JJ cord-005453-4057qib7 14706 3 BM bm NN cord-005453-4057qib7 14706 4 cells cell NNS cord-005453-4057qib7 14706 5 production production NN cord-005453-4057qib7 14706 6 occurs occur VBZ cord-005453-4057qib7 14706 7 very very RB cord-005453-4057qib7 14706 8 early early RB cord-005453-4057qib7 14706 9 in in IN cord-005453-4057qib7 14706 10 life life NN cord-005453-4057qib7 14706 11 , , , cord-005453-4057qib7 14706 12 the the DT cord-005453-4057qib7 14706 13 usual usual JJ cord-005453-4057qib7 14706 14 age age NN cord-005453-4057qib7 14706 15 of of IN cord-005453-4057qib7 14706 16 diagnosis diagnosis NN cord-005453-4057qib7 14706 17 is be VBZ cord-005453-4057qib7 14706 18 5 5 CD cord-005453-4057qib7 14706 19 - - SYM cord-005453-4057qib7 14706 20 10 10 CD cord-005453-4057qib7 14706 21 years year NNS cord-005453-4057qib7 14706 22 old old JJ cord-005453-4057qib7 14706 23 . . . cord-005453-4057qib7 14707 1 Gene gene NN cord-005453-4057qib7 14707 2 therapy therapy NN cord-005453-4057qib7 14707 3 ( ( -LRB- cord-005453-4057qib7 14707 4 GT GT NNP cord-005453-4057qib7 14707 5 ) ) -RRB- cord-005453-4057qib7 14707 6 might may MD cord-005453-4057qib7 14707 7 be be VB cord-005453-4057qib7 14707 8 an an DT cord-005453-4057qib7 14707 9 alternative alternative NN cord-005453-4057qib7 14707 10 to to IN cord-005453-4057qib7 14707 11 hematopoietic hematopoietic JJ cord-005453-4057qib7 14707 12 stem stem NN cord-005453-4057qib7 14707 13 cells cell NNS cord-005453-4057qib7 14707 14 ( ( -LRB- cord-005453-4057qib7 14707 15 HSC HSC NNP cord-005453-4057qib7 14707 16 ) ) -RRB- cord-005453-4057qib7 14707 17 transplantation transplantation NN cord-005453-4057qib7 14707 18 , , , cord-005453-4057qib7 14707 19 but but CC cord-005453-4057qib7 14707 20 harvest harvest VBP cord-005453-4057qib7 14707 21 a a DT cord-005453-4057qib7 14707 22 large large JJ cord-005453-4057qib7 14707 23 number number NN cord-005453-4057qib7 14707 24 of of IN cord-005453-4057qib7 14707 25 autologous autologous JJ cord-005453-4057qib7 14707 26 HSC HSC NNP cord-005453-4057qib7 14707 27 remains remain VBZ cord-005453-4057qib7 14707 28 a a DT cord-005453-4057qib7 14707 29 challenge challenge NN cord-005453-4057qib7 14707 30 . . . cord-005453-4057qib7 14708 1 We -PRON- PRP cord-005453-4057qib7 14708 2 started start VBD cord-005453-4057qib7 14708 3 a a DT cord-005453-4057qib7 14708 4 mobilization mobilization NN cord-005453-4057qib7 14708 5 assay assay NN cord-005453-4057qib7 14708 6 , , , cord-005453-4057qib7 14708 7 FancoMob FancoMob NNP cord-005453-4057qib7 14708 8 , , , cord-005453-4057qib7 14708 9 to to TO cord-005453-4057qib7 14708 10 evaluate evaluate VB cord-005453-4057qib7 14708 11 the the DT cord-005453-4057qib7 14708 12 safety safety NN cord-005453-4057qib7 14708 13 and and CC cord-005453-4057qib7 14708 14 the the DT cord-005453-4057qib7 14708 15 efficacy efficacy NN cord-005453-4057qib7 14708 16 of of IN cord-005453-4057qib7 14708 17 FA FA NNP cord-005453-4057qib7 14708 18 patients patient NNS cord-005453-4057qib7 14708 19 ' ' POS cord-005453-4057qib7 14708 20 mobilization mobilization NN cord-005453-4057qib7 14708 21 with with IN cord-005453-4057qib7 14708 22 granulocyte granulocyte NN cord-005453-4057qib7 14708 23 - - HYPH cord-005453-4057qib7 14708 24 colony colony NN cord-005453-4057qib7 14708 25 stimulating stimulate VBG cord-005453-4057qib7 14708 26 factor factor NN cord-005453-4057qib7 14708 27 ( ( -LRB- cord-005453-4057qib7 14708 28 G G NNP cord-005453-4057qib7 14708 29 - - HYPH cord-005453-4057qib7 14708 30 CSF CSF NNP cord-005453-4057qib7 14708 31 ) ) -RRB- cord-005453-4057qib7 14708 32 and and CC cord-005453-4057qib7 14708 33 plerixafor plerixafor NN cord-005453-4057qib7 14708 34 . . . cord-005453-4057qib7 14709 1 This this DT cord-005453-4057qib7 14709 2 study study NN cord-005453-4057qib7 14709 3 is be VBZ cord-005453-4057qib7 14709 4 part part NN cord-005453-4057qib7 14709 5 of of IN cord-005453-4057qib7 14709 6 the the DT cord-005453-4057qib7 14709 7 FA FA NNP cord-005453-4057qib7 14709 8 's 's POS cord-005453-4057qib7 14709 9 European european JJ cord-005453-4057qib7 14709 10 GT GT NNP cord-005453-4057qib7 14709 11 project project NN cord-005453-4057qib7 14709 12 " " `` cord-005453-4057qib7 14709 13 EuroFancolen EuroFancolen NNP cord-005453-4057qib7 14709 14 " " '' cord-005453-4057qib7 14709 15 . . . cord-005453-4057qib7 14710 1 Methods method NNS cord-005453-4057qib7 14710 2 : : : cord-005453-4057qib7 14710 3 Four four CD cord-005453-4057qib7 14710 4 patients patient NNS cord-005453-4057qib7 14710 5 with with IN cord-005453-4057qib7 14710 6 FANCA FANCA NNP cord-005453-4057qib7 14710 7 mutations mutation NNS cord-005453-4057qib7 14710 8 following follow VBG cord-005453-4057qib7 14710 9 the the DT cord-005453-4057qib7 14710 10 inclusion inclusion NN cord-005453-4057qib7 14710 11 criteria criterion NNS cord-005453-4057qib7 14710 12 were be VBD cord-005453-4057qib7 14710 13 selected select VBN cord-005453-4057qib7 14710 14 before before IN cord-005453-4057qib7 14710 15 pancytopenia pancytopenia NNP cord-005453-4057qib7 14710 16 . . . cord-005453-4057qib7 14711 1 To to TO cord-005453-4057qib7 14711 2 note note VB cord-005453-4057qib7 14711 3 , , , cord-005453-4057qib7 14711 4 FA4 FA4 NNP cord-005453-4057qib7 14711 5 was be VBD cord-005453-4057qib7 14711 6 diagnosed diagnose VBN cord-005453-4057qib7 14711 7 before before IN cord-005453-4057qib7 14711 8 clinical clinical JJ cord-005453-4057qib7 14711 9 manifestation manifestation NN cord-005453-4057qib7 14711 10 through through IN cord-005453-4057qib7 14711 11 family family NN cord-005453-4057qib7 14711 12 screening screening NN cord-005453-4057qib7 14711 13 . . . cord-005453-4057qib7 14712 1 They -PRON- PRP cord-005453-4057qib7 14712 2 received receive VBD cord-005453-4057qib7 14712 3 subcutaneous subcutaneous JJ cord-005453-4057qib7 14712 4 injection injection NN cord-005453-4057qib7 14712 5 of of IN cord-005453-4057qib7 14712 6 G G NNP cord-005453-4057qib7 14712 7 - - HYPH cord-005453-4057qib7 14712 8 CSF CSF NNP cord-005453-4057qib7 14712 9 ( ( -LRB- cord-005453-4057qib7 14712 10 12 12 CD cord-005453-4057qib7 14712 11 μg μg NNP cord-005453-4057qib7 14712 12 / / SYM cord-005453-4057qib7 14712 13 kg kg NNS cord-005453-4057qib7 14712 14 twice twice PDT cord-005453-4057qib7 14712 15 a a DT cord-005453-4057qib7 14712 16 day day NN cord-005453-4057qib7 14712 17 ) ) -RRB- cord-005453-4057qib7 14712 18 from from IN cord-005453-4057qib7 14712 19 D-1 D-1 NNP cord-005453-4057qib7 14712 20 and and CC cord-005453-4057qib7 14712 21 plerixafor plerixafor NN cord-005453-4057qib7 14712 22 ( ( -LRB- cord-005453-4057qib7 14712 23 0.24 0.24 CD cord-005453-4057qib7 14712 24 mg mg NNP cord-005453-4057qib7 14712 25 / / SYM cord-005453-4057qib7 14712 26 kg kg NNP cord-005453-4057qib7 14712 27 / / SYM cord-005453-4057qib7 14712 28 day day NN cord-005453-4057qib7 14712 29 ) ) -RRB- cord-005453-4057qib7 14712 30 from from IN cord-005453-4057qib7 14712 31 D-4 D-4 NNP cord-005453-4057qib7 14712 32 . . . cord-005453-4057qib7 14713 1 The the DT cord-005453-4057qib7 14713 2 collection collection NN cord-005453-4057qib7 14713 3 protocol protocol NN cord-005453-4057qib7 14713 4 targeted target VBN cord-005453-4057qib7 14713 5 3x10e6 3x10e6 NNP cord-005453-4057qib7 14713 6 / / SYM cord-005453-4057qib7 14713 7 Kg Kg NNP cord-005453-4057qib7 14713 8 of of IN cord-005453-4057qib7 14713 9 CD34 CD34 NNP cord-005453-4057qib7 14713 10 + + CC cord-005453-4057qib7 14713 11 cells cell NNS cord-005453-4057qib7 14713 12 , , , cord-005453-4057qib7 14713 13 based base VBN cord-005453-4057qib7 14713 14 on on IN cord-005453-4057qib7 14713 15 a a DT cord-005453-4057qib7 14713 16 predicted predict VBN cord-005453-4057qib7 14713 17 future future JJ cord-005453-4057qib7 14713 18 weight weight NN cord-005453-4057qib7 14713 19 in in IN cord-005453-4057qib7 14713 20 5 5 CD cord-005453-4057qib7 14713 21 years year NNS cord-005453-4057qib7 14713 22 . . . cord-005453-4057qib7 14714 1 CD34 CD34 NNP cord-005453-4057qib7 14714 2 + + CC cord-005453-4057qib7 14714 3 cells cell NNS cord-005453-4057qib7 14714 4 and and CC cord-005453-4057qib7 14714 5 white white JJ cord-005453-4057qib7 14714 6 blood blood NN cord-005453-4057qib7 14714 7 cells cell NNS cord-005453-4057qib7 14714 8 ( ( -LRB- cord-005453-4057qib7 14714 9 WBC WBC NNP cord-005453-4057qib7 14714 10 ) ) -RRB- cord-005453-4057qib7 14714 11 blood blood NN cord-005453-4057qib7 14714 12 count count NN cord-005453-4057qib7 14714 13 were be VBD cord-005453-4057qib7 14714 14 monitored monitor VBN cord-005453-4057qib7 14714 15 tightly tightly RB cord-005453-4057qib7 14714 16 along along IN cord-005453-4057qib7 14714 17 the the DT cord-005453-4057qib7 14714 18 mobilization mobilization NN cord-005453-4057qib7 14714 19 . . . cord-005453-4057qib7 14715 1 Patients patient NNS cord-005453-4057qib7 14715 2 with with IN cord-005453-4057qib7 14715 3 more more JJR cord-005453-4057qib7 14715 4 than than IN cord-005453-4057qib7 14715 5 10 10 CD cord-005453-4057qib7 14715 6 CD34 CD34 NNP cord-005453-4057qib7 14715 7 + + CC cord-005453-4057qib7 14715 8 /μl /μl : cord-005453-4057qib7 14715 9 or or CC cord-005453-4057qib7 14715 10 between between IN cord-005453-4057qib7 14715 11 5 5 CD cord-005453-4057qib7 14715 12 and and CC cord-005453-4057qib7 14715 13 10 10 CD cord-005453-4057qib7 14715 14 CD34 CD34 NNP cord-005453-4057qib7 14716 1 /μl /μl : cord-005453-4057qib7 14716 2 with with IN cord-005453-4057qib7 14716 3 a a DT cord-005453-4057qib7 14716 4 clustered clustered JJ cord-005453-4057qib7 14716 5 aspect aspect NN cord-005453-4057qib7 14716 6 detected detect VBN cord-005453-4057qib7 14716 7 by by IN cord-005453-4057qib7 14716 8 flow flow NN cord-005453-4057qib7 14716 9 cytometry cytometry NN cord-005453-4057qib7 14716 10 after after IN cord-005453-4057qib7 14716 11 plerixafor plerixafor NN cord-005453-4057qib7 14716 12 injection injection NN cord-005453-4057qib7 14716 13 underwent undergo VBD cord-005453-4057qib7 14716 14 apheresis apheresis NN cord-005453-4057qib7 14716 15 . . . cord-005453-4057qib7 14717 1 CD34 CD34 NNP cord-005453-4057qib7 14717 2 + + CC cord-005453-4057qib7 14717 3 cells cell NNS cord-005453-4057qib7 14717 4 were be VBD cord-005453-4057qib7 14717 5 immunoselected immunoselecte VBN cord-005453-4057qib7 14717 6 from from IN cord-005453-4057qib7 14717 7 the the DT cord-005453-4057qib7 14717 8 collection collection NN cord-005453-4057qib7 14717 9 with with IN cord-005453-4057qib7 14717 10 CliniMACS CliniMACS NNP cord-005453-4057qib7 14717 11 purification purification NN cord-005453-4057qib7 14717 12 system system NN cord-005453-4057qib7 14717 13 ( ( -LRB- cord-005453-4057qib7 14717 14 Miltenyi Miltenyi NNP cord-005453-4057qib7 14717 15 ) ) -RRB- cord-005453-4057qib7 14717 16 and and CC cord-005453-4057qib7 14717 17 cryopreserved cryopreserve VBN cord-005453-4057qib7 14717 18 for for IN cord-005453-4057qib7 14717 19 further further JJ cord-005453-4057qib7 14717 20 GT GT NNP cord-005453-4057qib7 14717 21 manipulation manipulation NN cord-005453-4057qib7 14717 22 . . . cord-005453-4057qib7 14718 1 Results result NNS cord-005453-4057qib7 14718 2 : : : cord-005453-4057qib7 14719 1 The the DT cord-005453-4057qib7 14719 2 mobilization mobilization NN cord-005453-4057qib7 14719 3 target target NN cord-005453-4057qib7 14719 4 was be VBD cord-005453-4057qib7 14719 5 not not RB cord-005453-4057qib7 14719 6 achieved achieve VBN cord-005453-4057qib7 14719 7 for for IN cord-005453-4057qib7 14719 8 the the DT cord-005453-4057qib7 14719 9 first first JJ cord-005453-4057qib7 14719 10 two two CD cord-005453-4057qib7 14719 11 included include VBN cord-005453-4057qib7 14719 12 patients patient NNS cord-005453-4057qib7 14719 13 ( ( -LRB- cord-005453-4057qib7 14719 14 FA1 FA1 NNP cord-005453-4057qib7 14719 15 12 12 CD cord-005453-4057qib7 14719 16 years year NNS cord-005453-4057qib7 14719 17 old old JJ cord-005453-4057qib7 14719 18 and and CC cord-005453-4057qib7 14719 19 FA2 fa2 JJ cord-005453-4057qib7 14719 20 8 8 CD cord-005453-4057qib7 14719 21 years year NNS cord-005453-4057qib7 14719 22 old old JJ cord-005453-4057qib7 14719 23 ) ) -RRB- cord-005453-4057qib7 14719 24 . . . cord-005453-4057qib7 14720 1 The the DT cord-005453-4057qib7 14720 2 minimum minimum JJ cord-005453-4057qib7 14720 3 value value NN cord-005453-4057qib7 14720 4 of of IN cord-005453-4057qib7 14720 5 CD34+/μl CD34+/μl NNP cord-005453-4057qib7 14720 6 required require VBN cord-005453-4057qib7 14720 7 was be VBD cord-005453-4057qib7 14720 8 n't not RB cord-005453-4057qib7 14720 9 obtained obtain VBN cord-005453-4057qib7 14720 10 for for IN cord-005453-4057qib7 14720 11 FA1 FA1 NNP cord-005453-4057qib7 14720 12 and and CC cord-005453-4057qib7 14720 13 the the DT cord-005453-4057qib7 14720 14 flow flow NN cord-005453-4057qib7 14720 15 cytometry cytometry NN cord-005453-4057qib7 14720 16 CD34 CD34 NNP cord-005453-4057qib7 14720 17 + + CC cord-005453-4057qib7 14720 18 aspect aspect NN cord-005453-4057qib7 14720 19 was be VBD cord-005453-4057qib7 14720 20 not not RB cord-005453-4057qib7 14720 21 clustered cluster VBN cord-005453-4057qib7 14720 22 for for IN cord-005453-4057qib7 14720 23 FA2 FA2 NNP cord-005453-4057qib7 14720 24 . . . cord-005453-4057qib7 14721 1 CD34 CD34 NNP cord-005453-4057qib7 14721 2 + + CC cord-005453-4057qib7 14721 3 cells cell NNS cord-005453-4057qib7 14721 4 were be VBD cord-005453-4057qib7 14721 5 mobilized mobilize VBN cord-005453-4057qib7 14721 6 quickly quickly RB cord-005453-4057qib7 14721 7 but but CC cord-005453-4057qib7 14721 8 transitionally transitionally RB cord-005453-4057qib7 14721 9 after after IN cord-005453-4057qib7 14721 10 plerixafor plerixafor NN cord-005453-4057qib7 14721 11 injection injection NN cord-005453-4057qib7 14721 12 for for IN cord-005453-4057qib7 14721 13 the the DT cord-005453-4057qib7 14721 14 last last JJ cord-005453-4057qib7 14721 15 two two CD cord-005453-4057qib7 14721 16 patients patient NNS cord-005453-4057qib7 14721 17 , , , cord-005453-4057qib7 14721 18 FA3 FA3 NNP cord-005453-4057qib7 14721 19 and and CC cord-005453-4057qib7 14721 20 FA4 FA4 NNP cord-005453-4057qib7 14721 21 , , , cord-005453-4057qib7 14721 22 5 5 CD cord-005453-4057qib7 14721 23 and and CC cord-005453-4057qib7 14721 24 2 2 CD cord-005453-4057qib7 14721 25 years year NNS cord-005453-4057qib7 14721 26 old old JJ cord-005453-4057qib7 14721 27 respectively respectively RB cord-005453-4057qib7 14721 28 . . . cord-005453-4057qib7 14722 1 Both both DT cord-005453-4057qib7 14722 2 patients patient NNS cord-005453-4057qib7 14722 3 underwent undergo VBD cord-005453-4057qib7 14722 4 apheresis apheresis NN cord-005453-4057qib7 14722 5 procedures procedure NNS cord-005453-4057qib7 14722 6 . . . cord-005453-4057qib7 14723 1 No no DT cord-005453-4057qib7 14723 2 CD34 CD34 NNP cord-005453-4057qib7 14723 3 + + CC cord-005453-4057qib7 14723 4 cell cell NN cord-005453-4057qib7 14723 5 rebound rebound NN cord-005453-4057qib7 14723 6 was be VBD cord-005453-4057qib7 14723 7 observed observe VBN cord-005453-4057qib7 14723 8 after after IN cord-005453-4057qib7 14723 9 the the DT cord-005453-4057qib7 14723 10 apheresis apheresis NN cord-005453-4057qib7 14723 11 was be VBD cord-005453-4057qib7 14723 12 stopped stop VBN cord-005453-4057qib7 14723 13 . . . cord-005453-4057qib7 14724 1 Collection collection NN cord-005453-4057qib7 14724 2 target target NN cord-005453-4057qib7 14724 3 was be VBD cord-005453-4057qib7 14724 4 not not RB cord-005453-4057qib7 14724 5 achieved achieve VBN cord-005453-4057qib7 14724 6 after after IN cord-005453-4057qib7 14724 7 four four CD cord-005453-4057qib7 14724 8 days day NNS cord-005453-4057qib7 14724 9 of of IN cord-005453-4057qib7 14724 10 collection collection NN cord-005453-4057qib7 14724 11 for for IN cord-005453-4057qib7 14724 12 FA3 FA3 NNP cord-005453-4057qib7 14724 13 . . . cord-005453-4057qib7 14725 1 It -PRON- PRP cord-005453-4057qib7 14725 2 was be VBD cord-005453-4057qib7 14725 3 obtained obtain VBN cord-005453-4057qib7 14725 4 the the DT cord-005453-4057qib7 14725 5 first first JJ cord-005453-4057qib7 14725 6 day day NN cord-005453-4057qib7 14725 7 for for IN cord-005453-4057qib7 14725 8 FA4 FA4 NNP cord-005453-4057qib7 14725 9 ( ( -LRB- cord-005453-4057qib7 14725 10 Figure figure NN cord-005453-4057qib7 14725 11 1 1 CD cord-005453-4057qib7 14725 12 ) ) -RRB- cord-005453-4057qib7 14725 13 . . . cord-005453-4057qib7 14726 1 Back back NN cord-005453-4057qib7 14726 2 - - HYPH cord-005453-4057qib7 14726 3 up up NN cord-005453-4057qib7 14726 4 for for IN cord-005453-4057qib7 14726 5 HSC HSC NNP cord-005453-4057qib7 14726 6 transplantation transplantation NN cord-005453-4057qib7 14726 7 could could MD cord-005453-4057qib7 14726 8 not not RB cord-005453-4057qib7 14726 9 be be VB cord-005453-4057qib7 14726 10 cryopreserved cryopreserve VBN cord-005453-4057qib7 14726 11 because because IN cord-005453-4057qib7 14726 12 of of IN cord-005453-4057qib7 14726 13 the the DT cord-005453-4057qib7 14726 14 limited limited JJ cord-005453-4057qib7 14726 15 number number NN cord-005453-4057qib7 14726 16 of of IN cord-005453-4057qib7 14726 17 CD34 CD34 NNP cord-005453-4057qib7 14726 18 + + CC cord-005453-4057qib7 14727 1 cells cell NNS cord-005453-4057qib7 14727 2 collected collect VBN cord-005453-4057qib7 14727 3 in in IN cord-005453-4057qib7 14727 4 patients patient NNS cord-005453-4057qib7 14727 5 FA3 FA3 NNP cord-005453-4057qib7 14727 6 and and CC cord-005453-4057qib7 14727 7 FA4 FA4 NNP cord-005453-4057qib7 14727 8 . . . cord-005453-4057qib7 14728 1 No no DT cord-005453-4057qib7 14728 2 short short JJ cord-005453-4057qib7 14728 3 - - HYPH cord-005453-4057qib7 14728 4 term term NN cord-005453-4057qib7 14728 5 adverse adverse JJ cord-005453-4057qib7 14728 6 events event NNS cord-005453-4057qib7 14728 7 were be VBD cord-005453-4057qib7 14728 8 observed observe VBN cord-005453-4057qib7 14728 9 . . . cord-005453-4057qib7 14729 1 Following follow VBG cord-005453-4057qib7 14729 2 CD34 CD34 NNP cord-005453-4057qib7 14729 3 + + CC cord-005453-4057qib7 14729 4 immunoselection immunoselection NN cord-005453-4057qib7 14729 5 , , , cord-005453-4057qib7 14729 6 CD34 CD34 NNP cord-005453-4057qib7 14729 7 + + CC cord-005453-4057qib7 14729 8 cell cell NN cord-005453-4057qib7 14729 9 purity purity NN cord-005453-4057qib7 14729 10 and and CC cord-005453-4057qib7 14729 11 recovery recovery NN cord-005453-4057qib7 14729 12 were be VBD cord-005453-4057qib7 14729 13 poor poor JJ cord-005453-4057qib7 14729 14 but but CC cord-005453-4057qib7 14729 15 in in IN cord-005453-4057qib7 14729 16 the the DT cord-005453-4057qib7 14729 17 normal normal JJ cord-005453-4057qib7 14729 18 range range NN cord-005453-4057qib7 14729 19 described describe VBN cord-005453-4057qib7 14729 20 in in IN cord-005453-4057qib7 14729 21 the the DT cord-005453-4057qib7 14729 22 literature literature NN cord-005453-4057qib7 14729 23 for for IN cord-005453-4057qib7 14729 24 Fanconi Fanconi NNP cord-005453-4057qib7 14729 25 patients patient NNS cord-005453-4057qib7 14729 26 ( ( -LRB- cord-005453-4057qib7 14729 27 8 8 CD cord-005453-4057qib7 14729 28 - - SYM cord-005453-4057qib7 14729 29 20 20 CD cord-005453-4057qib7 14729 30 % % NN cord-005453-4057qib7 14729 31 ) ) -RRB- cord-005453-4057qib7 14730 1 ( ( -LRB- cord-005453-4057qib7 14730 2 Table table NN cord-005453-4057qib7 14730 3 I i CD cord-005453-4057qib7 14730 4 ) ) -RRB- cord-005453-4057qib7 14730 5 . . . cord-005453-4057qib7 14731 1 One one CD cord-005453-4057qib7 14731 2 month month NN cord-005453-4057qib7 14731 3 after after IN cord-005453-4057qib7 14731 4 the the DT cord-005453-4057qib7 14731 5 collection collection NN cord-005453-4057qib7 14731 6 hemograms hemogram NNS cord-005453-4057qib7 14731 7 were be VBD cord-005453-4057qib7 14731 8 unchanged unchanged JJ cord-005453-4057qib7 14731 9 . . . cord-005453-4057qib7 14732 1 Conclusions conclusion NNS cord-005453-4057qib7 14732 2 : : : cord-005453-4057qib7 14733 1 Our -PRON- PRP$ cord-005453-4057qib7 14733 2 clinical clinical JJ cord-005453-4057qib7 14733 3 study study NN cord-005453-4057qib7 14733 4 offer offer VBP cord-005453-4057qib7 14733 5 new new JJ cord-005453-4057qib7 14733 6 data datum NNS cord-005453-4057qib7 14733 7 showing show VBG cord-005453-4057qib7 14733 8 that that IN cord-005453-4057qib7 14733 9 mobilization mobilization NN cord-005453-4057qib7 14733 10 of of IN cord-005453-4057qib7 14733 11 FA FA NNP cord-005453-4057qib7 14733 12 patients patient NNS cord-005453-4057qib7 14733 13 with with IN cord-005453-4057qib7 14733 14 G G NNP cord-005453-4057qib7 14733 15 - - HYPH cord-005453-4057qib7 14733 16 CSF csf NN cord-005453-4057qib7 14733 17 and and CC cord-005453-4057qib7 14733 18 plerixafor plerixafor NN cord-005453-4057qib7 14733 19 is be VBZ cord-005453-4057qib7 14733 20 safe safe JJ cord-005453-4057qib7 14733 21 and and CC cord-005453-4057qib7 14733 22 more more RBR cord-005453-4057qib7 14733 23 efficient efficient JJ cord-005453-4057qib7 14733 24 for for IN cord-005453-4057qib7 14733 25 younger young JJR cord-005453-4057qib7 14733 26 patients patient NNS cord-005453-4057qib7 14733 27 , , , cord-005453-4057qib7 14733 28 especially especially RB cord-005453-4057qib7 14733 29 before before IN cord-005453-4057qib7 14733 30 clinical clinical JJ cord-005453-4057qib7 14733 31 manifestations manifestation NNS cord-005453-4057qib7 14733 32 of of IN cord-005453-4057qib7 14733 33 BM BM NNP cord-005453-4057qib7 14733 34 failure failure NN cord-005453-4057qib7 14733 35 . . . cord-005453-4057qib7 14734 1 Further further JJ cord-005453-4057qib7 14734 2 efforts effort NNS cord-005453-4057qib7 14734 3 are be VBP cord-005453-4057qib7 14734 4 required require VBN cord-005453-4057qib7 14734 5 to to TO cord-005453-4057qib7 14734 6 establish establish VB cord-005453-4057qib7 14734 7 an an DT cord-005453-4057qib7 14734 8 effective effective JJ cord-005453-4057qib7 14734 9 technic technic NN cord-005453-4057qib7 14734 10 to to TO cord-005453-4057qib7 14734 11 purify purify VB cord-005453-4057qib7 14734 12 the the DT cord-005453-4057qib7 14734 13 CD34 CD34 NNP cord-005453-4057qib7 14734 14 + + CC cord-005453-4057qib7 14734 15 cells cell NNS cord-005453-4057qib7 14734 16 after after IN cord-005453-4057qib7 14734 17 harvesting harvest VBG cord-005453-4057qib7 14734 18 . . . cord-005453-4057qib7 14734 19 _SP cord-005453-4057qib7 14735 1 Basal Basal NNP cord-005453-4057qib7 14735 2 CD34 CD34 NNP cord-005453-4057qib7 14735 3 + + CC cord-005453-4057qib7 14735 4 cell cell NN cord-005453-4057qib7 14735 5 and and CC cord-005453-4057qib7 14735 6 platelets platelet NNS cord-005453-4057qib7 14735 7 count count NN cord-005453-4057qib7 14735 8 are be VBP cord-005453-4057qib7 14735 9 a a DT cord-005453-4057qib7 14735 10 strong strong JJ cord-005453-4057qib7 14735 11 predictor predictor NN cord-005453-4057qib7 14735 12 for for IN cord-005453-4057qib7 14735 13 mobilized mobilize VBN cord-005453-4057qib7 14735 14 peripheral peripheral JJ cord-005453-4057qib7 14735 15 blood blood NN cord-005453-4057qib7 14735 16 stem stem NN cord-005453-4057qib7 14735 17 cells cell NNS cord-005453-4057qib7 14735 18 on on IN cord-005453-4057qib7 14735 19 the the DT cord-005453-4057qib7 14735 20 4th 4th JJ cord-005453-4057qib7 14735 21 day day NN cord-005453-4057qib7 14735 22 of of IN cord-005453-4057qib7 14735 23 G G NNP cord-005453-4057qib7 14735 24 - - HYPH cord-005453-4057qib7 14735 25 CSF csf NN cord-005453-4057qib7 14735 26 treatment treatment NN cord-005453-4057qib7 14735 27 in in IN cord-005453-4057qib7 14735 28 donors donor NNS cord-005453-4057qib7 14735 29 cryopreserved cryopreserve VBN cord-005453-4057qib7 14735 30 PBSCs pbsc NNS cord-005453-4057qib7 14735 31 . . . cord-005453-4057qib7 14736 1 This this DT cord-005453-4057qib7 14736 2 was be VBD cord-005453-4057qib7 14736 3 associated associate VBN cord-005453-4057qib7 14736 4 with with IN cord-005453-4057qib7 14736 5 considerable considerable JJ cord-005453-4057qib7 14736 6 efforts effort NNS cord-005453-4057qib7 14736 7 for for IN cord-005453-4057qib7 14736 8 the the DT cord-005453-4057qib7 14736 9 patients patient NNS cord-005453-4057qib7 14736 10 and and CC cord-005453-4057qib7 14736 11 caused cause VBD cord-005453-4057qib7 14736 12 additional additional JJ cord-005453-4057qib7 14736 13 treatment treatment NN cord-005453-4057qib7 14736 14 costs cost NNS cord-005453-4057qib7 14736 15 . . . cord-005453-4057qib7 14737 1 On on IN cord-005453-4057qib7 14737 2 the the DT cord-005453-4057qib7 14737 3 one one CD cord-005453-4057qib7 14737 4 hand hand NN cord-005453-4057qib7 14737 5 , , , cord-005453-4057qib7 14737 6 having have VBG cord-005453-4057qib7 14737 7 the the DT cord-005453-4057qib7 14737 8 therapeutic therapeutic JJ cord-005453-4057qib7 14737 9 option option NN cord-005453-4057qib7 14737 10 of of IN cord-005453-4057qib7 14737 11 an an DT cord-005453-4057qib7 14737 12 autologous autologous JJ cord-005453-4057qib7 14737 13 transplantation transplantation NN cord-005453-4057qib7 14737 14 in in IN cord-005453-4057qib7 14737 15 the the DT cord-005453-4057qib7 14737 16 future future NN cord-005453-4057qib7 14737 17 may may MD cord-005453-4057qib7 14737 18 represent represent VB cord-005453-4057qib7 14737 19 a a DT cord-005453-4057qib7 14737 20 clinically clinically RB cord-005453-4057qib7 14737 21 relevant relevant JJ cord-005453-4057qib7 14737 22 advantage advantage NN cord-005453-4057qib7 14737 23 . . . cord-005453-4057qib7 14738 1 However however RB cord-005453-4057qib7 14738 2 , , , cord-005453-4057qib7 14738 3 a a DT cord-005453-4057qib7 14738 4 huge huge JJ cord-005453-4057qib7 14738 5 number number NN cord-005453-4057qib7 14738 6 of of IN cord-005453-4057qib7 14738 7 stem stem NN cord-005453-4057qib7 14738 8 cell cell NN cord-005453-4057qib7 14738 9 products product NNS cord-005453-4057qib7 14738 10 are be VBP cord-005453-4057qib7 14738 11 kept keep VBN cord-005453-4057qib7 14738 12 in in IN cord-005453-4057qib7 14738 13 storage storage NN cord-005453-4057qib7 14738 14 for for IN cord-005453-4057qib7 14738 15 many many JJ cord-005453-4057qib7 14738 16 years year NNS cord-005453-4057qib7 14738 17 without without IN cord-005453-4057qib7 14738 18 ever ever RB cord-005453-4057qib7 14738 19 been be VBN cord-005453-4057qib7 14738 20 used use VBN cord-005453-4057qib7 14738 21 for for IN cord-005453-4057qib7 14738 22 transplantation transplantation NN cord-005453-4057qib7 14738 23 . . . cord-005453-4057qib7 14739 1 Our -PRON- PRP$ cord-005453-4057qib7 14739 2 study study NN cord-005453-4057qib7 14739 3 provides provide VBZ cord-005453-4057qib7 14739 4 cause cause NN cord-005453-4057qib7 14739 5 for for IN cord-005453-4057qib7 14739 6 a a DT cord-005453-4057qib7 14739 7 careful careful JJ cord-005453-4057qib7 14739 8 reevaluation reevaluation NN cord-005453-4057qib7 14739 9 of of IN cord-005453-4057qib7 14739 10 the the DT cord-005453-4057qib7 14739 11 current current JJ cord-005453-4057qib7 14739 12 clinical clinical JJ cord-005453-4057qib7 14739 13 practice practice NN cord-005453-4057qib7 14739 14 , , , cord-005453-4057qib7 14739 15 which which WDT cord-005453-4057qib7 14739 16 may may MD cord-005453-4057qib7 14739 17 help help VB cord-005453-4057qib7 14739 18 to to TO cord-005453-4057qib7 14739 19 focus focus VB cord-005453-4057qib7 14739 20 more more RBR cord-005453-4057qib7 14739 21 precisely precisely RB cord-005453-4057qib7 14739 22 on on IN cord-005453-4057qib7 14739 23 patients patient NNS cord-005453-4057qib7 14739 24 who who WP cord-005453-4057qib7 14739 25 actually actually RB cord-005453-4057qib7 14739 26 benefit benefit VBP cord-005453-4057qib7 14739 27 from from IN cord-005453-4057qib7 14739 28 a a DT cord-005453-4057qib7 14739 29 cryostored cryostore VBN cord-005453-4057qib7 14739 30 autologous autologous JJ cord-005453-4057qib7 14739 31 stem stem NN cord-005453-4057qib7 14739 32 cell cell NN cord-005453-4057qib7 14739 33 graft graft NN cord-005453-4057qib7 14739 34 . . . cord-005453-4057qib7 14740 1 [ [ -LRB- cord-005453-4057qib7 14740 2 [ [ -LRB- cord-005453-4057qib7 14740 3 P693 P693 JJR cord-005453-4057qib7 14740 4 Image image NN cord-005453-4057qib7 14740 5 ] ] -RRB- cord-005453-4057qib7 14740 6 1 1 CD cord-005453-4057qib7 14740 7 . . . cord-005453-4057qib7 14741 1 Fig Fig NNP cord-005453-4057qib7 14741 2 . . NNP cord-005453-4057qib7 14741 3 1 1 CD cord-005453-4057qib7 14741 4 : : : cord-005453-4057qib7 14742 1 Absolute absolute JJ cord-005453-4057qib7 14742 2 numbers number NNS cord-005453-4057qib7 14742 3 and and CC cord-005453-4057qib7 14742 4 relative relative JJ cord-005453-4057qib7 14742 5 distribution distribution NN cord-005453-4057qib7 14742 6 of of IN cord-005453-4057qib7 14742 7 stem stem NN cord-005453-4057qib7 14742 8 cell cell NN cord-005453-4057qib7 14742 9 grafts graft NNS cord-005453-4057qib7 14743 1 ] ] -RRB- cord-005453-4057qib7 14744 1 Disclosure disclosure NN cord-005453-4057qib7 14744 2 : : : cord-005453-4057qib7 14744 3 The the DT cord-005453-4057qib7 14744 4 authors author NNS cord-005453-4057qib7 14744 5 confirm confirm VBP cord-005453-4057qib7 14744 6 that that IN cord-005453-4057qib7 14744 7 there there EX cord-005453-4057qib7 14744 8 are be VBP cord-005453-4057qib7 14744 9 no no DT cord-005453-4057qib7 14744 10 potential potential JJ cord-005453-4057qib7 14744 11 conflicts conflict NNS cord-005453-4057qib7 14744 12 of of IN cord-005453-4057qib7 14744 13 interest interest NN cord-005453-4057qib7 14744 14 to to TO cord-005453-4057qib7 14744 15 disclose disclose VB cord-005453-4057qib7 14744 16 , , , cord-005453-4057qib7 14744 17 except except IN cord-005453-4057qib7 14744 18 the the DT cord-005453-4057qib7 14744 19 following follow VBG cord-005453-4057qib7 14744 20 : : : cord-005453-4057qib7 14744 21 Katharina Katharina NNP cord-005453-4057qib7 14744 22 Kriegsmann Kriegsmann NNP cord-005453-4057qib7 14744 23 : : : cord-005453-4057qib7 14744 24 research research NN cord-005453-4057qib7 14744 25 funding funding NN cord-005453-4057qib7 14744 26 from from IN cord-005453-4057qib7 14744 27 BMS BMS NNP cord-005453-4057qib7 14744 28 , , , cord-005453-4057qib7 14744 29 Celgene Celgene NNP cord-005453-4057qib7 14744 30 , , , cord-005453-4057qib7 14744 31 and and CC cord-005453-4057qib7 14744 32 Sanofi Sanofi NNP cord-005453-4057qib7 14744 33 . . . cord-005453-4057qib7 14745 1 Patrick Patrick NNP cord-005453-4057qib7 14745 2 Wuchter Wuchter NNP cord-005453-4057qib7 14745 3 : : : cord-005453-4057qib7 14745 4 Membership Membership NNP cord-005453-4057qib7 14745 5 in in IN cord-005453-4057qib7 14745 6 Advisory Advisory NNP cord-005453-4057qib7 14745 7 Boards Boards NNP cord-005453-4057qib7 14745 8 for for IN cord-005453-4057qib7 14745 9 Sanofi Sanofi NNP cord-005453-4057qib7 14745 10 - - HYPH cord-005453-4057qib7 14745 11 Aventis Aventis NNP cord-005453-4057qib7 14745 12 . . . cord-005453-4057qib7 14746 1 Reduction reduction NN cord-005453-4057qib7 14746 2 of of IN cord-005453-4057qib7 14746 3 dimethylsulfoxide dimethylsulfoxide NN cord-005453-4057qib7 14746 4 ( ( -LRB- cord-005453-4057qib7 14746 5 DMSO DMSO NNP cord-005453-4057qib7 14746 6 ) ) -RRB- cord-005453-4057qib7 14746 7 concentration concentration NN cord-005453-4057qib7 14746 8 from from IN cord-005453-4057qib7 14746 9 10 10 CD cord-005453-4057qib7 14746 10 % % NN cord-005453-4057qib7 14746 11 to to TO cord-005453-4057qib7 14746 12 5 5 CD cord-005453-4057qib7 14746 13 % % NN cord-005453-4057qib7 14746 14 in in IN cord-005453-4057qib7 14746 15 criopreservation criopreservation NN cord-005453-4057qib7 14746 16 of of IN cord-005453-4057qib7 14746 17 stem stem NN cord-005453-4057qib7 14746 18 cells cell NNS cord-005453-4057qib7 14746 19 . . . cord-005453-4057qib7 14747 1 Influence influence NN cord-005453-4057qib7 14747 2 on on IN cord-005453-4057qib7 14747 3 the the DT cord-005453-4057qib7 14747 4 kinetics kinetic NNS cord-005453-4057qib7 14747 5 of of IN cord-005453-4057qib7 14747 6 engraftment engraftment NN cord-005453-4057qib7 14747 7 and and CC cord-005453-4057qib7 14747 8 tolerance tolerance NN cord-005453-4057qib7 14747 9 to to TO cord-005453-4057qib7 14747 10 infusion infusion NN cord-005453-4057qib7 14747 11 Patricia Patricia NNP cord-005453-4057qib7 14747 12 Lopez Lopez NNP cord-005453-4057qib7 14747 13 - - HYPH cord-005453-4057qib7 14747 14 Pereira Pereira NNP cord-005453-4057qib7 14747 15 1 1 CD cord-005453-4057qib7 14747 16 , , , cord-005453-4057qib7 14747 17 Beatriz Beatriz NNP cord-005453-4057qib7 14747 18 Aguado Aguado NNP cord-005453-4057qib7 14747 19 1 1 CD cord-005453-4057qib7 14747 20 , , , cord-005453-4057qib7 14747 21 Elena Elena NNP cord-005453-4057qib7 14747 22 Sola Sola NNP cord-005453-4057qib7 14747 23 1 1 CD cord-005453-4057qib7 14747 24 , , , cord-005453-4057qib7 14747 25 Carmen Carmen NNP cord-005453-4057qib7 14747 26 Cámara Cámara NNP cord-005453-4057qib7 14747 27 1 1 CD cord-005453-4057qib7 14747 28 , , , cord-005453-4057qib7 14747 29 Isabel Isabel NNP cord-005453-4057qib7 14747 30 Vicuña Vicuña NNP cord-005453-4057qib7 14747 31 1 1 CD cord-005453-4057qib7 14747 32 , , , cord-005453-4057qib7 14747 33 Lorena Lorena NNP cord-005453-4057qib7 14747 34 Vega Vega NNP cord-005453-4057qib7 14747 35 1 1 CD cord-005453-4057qib7 14747 36 , , , cord-005453-4057qib7 14747 37 Adrian Adrian NNP cord-005453-4057qib7 14747 38 Alegre Alegre NNP cord-005453-4057qib7 14747 39 1 1 CD cord-005453-4057qib7 14747 40 1 1 CD cord-005453-4057qib7 14747 41 Hospital Hospital NNP cord-005453-4057qib7 14747 42 Universitario Universitario NNP cord-005453-4057qib7 14747 43 de de NNP cord-005453-4057qib7 14747 44 la la NNP cord-005453-4057qib7 14747 45 Princesa Princesa NNP cord-005453-4057qib7 14747 46 , , , cord-005453-4057qib7 14747 47 Madrid Madrid NNP cord-005453-4057qib7 14747 48 , , , cord-005453-4057qib7 14748 1 Spain Spain NNP cord-005453-4057qib7 14748 2 Background Background NNP cord-005453-4057qib7 14748 3 : : : cord-005453-4057qib7 14749 1 DMSO DMSO NNP cord-005453-4057qib7 14749 2 is be VBZ cord-005453-4057qib7 14749 3 the the DT cord-005453-4057qib7 14749 4 cryoprotectant cryoprotectant NN cord-005453-4057qib7 14749 5 most most RBS cord-005453-4057qib7 14749 6 used use VBN cord-005453-4057qib7 14749 7 in in IN cord-005453-4057qib7 14749 8 the the DT cord-005453-4057qib7 14749 9 cryopreservation cryopreservation NN cord-005453-4057qib7 14749 10 of of IN cord-005453-4057qib7 14749 11 stem stem NN cord-005453-4057qib7 14749 12 cells cell NNS cord-005453-4057qib7 14749 13 . . . cord-005453-4057qib7 14750 1 It -PRON- PRP cord-005453-4057qib7 14750 2 is be VBZ cord-005453-4057qib7 14750 3 associated associate VBN cord-005453-4057qib7 14750 4 with with IN cord-005453-4057qib7 14750 5 adverse adverse JJ cord-005453-4057qib7 14750 6 effects effect NNS cord-005453-4057qib7 14750 7 during during IN cord-005453-4057qib7 14750 8 the the DT cord-005453-4057qib7 14750 9 infusion infusion NN cord-005453-4057qib7 14750 10 of of IN cord-005453-4057qib7 14750 11 the the DT cord-005453-4057qib7 14750 12 product product NN cord-005453-4057qib7 14750 13 , , , cord-005453-4057qib7 14750 14 its -PRON- PRP$ cord-005453-4057qib7 14750 15 toxicity toxicity NN cord-005453-4057qib7 14750 16 being be VBG cord-005453-4057qib7 14750 17 proportional proportional JJ cord-005453-4057qib7 14750 18 to to IN cord-005453-4057qib7 14750 19 the the DT cord-005453-4057qib7 14750 20 volume volume NN cord-005453-4057qib7 14750 21 infused infuse VBN cord-005453-4057qib7 14750 22 . . . cord-005453-4057qib7 14751 1 The the DT cord-005453-4057qib7 14751 2 most most RBS cord-005453-4057qib7 14751 3 common common JJ cord-005453-4057qib7 14751 4 concentration concentration NN cord-005453-4057qib7 14751 5 used use VBN cord-005453-4057qib7 14751 6 has have VBZ cord-005453-4057qib7 14751 7 been be VBN cord-005453-4057qib7 14751 8 10 10 CD cord-005453-4057qib7 14751 9 % % NN cord-005453-4057qib7 14751 10 , , , cord-005453-4057qib7 14751 11 although although IN cord-005453-4057qib7 14751 12 recent recent JJ cord-005453-4057qib7 14751 13 publications publication NNS cord-005453-4057qib7 14751 14 report report VBP cord-005453-4057qib7 14751 15 that that IN cord-005453-4057qib7 14751 16 reducing reduce VBG cord-005453-4057qib7 14751 17 it -PRON- PRP cord-005453-4057qib7 14751 18 to to IN cord-005453-4057qib7 14751 19 5 5 CD cord-005453-4057qib7 14751 20 % % NN cord-005453-4057qib7 14751 21 leads lead VBZ cord-005453-4057qib7 14751 22 to to IN cord-005453-4057qib7 14751 23 lower low JJR cord-005453-4057qib7 14751 24 rate rate NN cord-005453-4057qib7 14751 25 of of IN cord-005453-4057qib7 14751 26 side side NN cord-005453-4057qib7 14751 27 effects effect NNS cord-005453-4057qib7 14751 28 without without IN cord-005453-4057qib7 14751 29 impact impact NN cord-005453-4057qib7 14751 30 on on IN cord-005453-4057qib7 14751 31 the the DT cord-005453-4057qib7 14751 32 product product NN cord-005453-4057qib7 14751 33 or or CC cord-005453-4057qib7 14751 34 the the DT cord-005453-4057qib7 14751 35 graft graft NN cord-005453-4057qib7 14751 36 . . . cord-005453-4057qib7 14752 1 We -PRON- PRP cord-005453-4057qib7 14752 2 retrospectively retrospectively RB cord-005453-4057qib7 14752 3 analyzed analyze VBD cord-005453-4057qib7 14752 4 207 207 CD cord-005453-4057qib7 14752 5 patients patient NNS cord-005453-4057qib7 14752 6 recipients recipient NNS cord-005453-4057qib7 14752 7 of of IN cord-005453-4057qib7 14752 8 autologous autologous JJ cord-005453-4057qib7 14752 9 peripheral peripheral JJ cord-005453-4057qib7 14752 10 blood blood NN cord-005453-4057qib7 14752 11 stem stem NN cord-005453-4057qib7 14752 12 cell cell NN cord-005453-4057qib7 14752 13 transplantation transplantation NN cord-005453-4057qib7 14752 14 ( ( -LRB- cord-005453-4057qib7 14752 15 HCT HCT NNP cord-005453-4057qib7 14752 16 ) ) -RRB- cord-005453-4057qib7 14752 17 in in IN cord-005453-4057qib7 14752 18 our -PRON- PRP$ cord-005453-4057qib7 14752 19 hospital hospital NN cord-005453-4057qib7 14752 20 from from IN cord-005453-4057qib7 14752 21 January January NNP cord-005453-4057qib7 14752 22 2009 2009 CD cord-005453-4057qib7 14752 23 to to IN cord-005453-4057qib7 14752 24 September September NNP cord-005453-4057qib7 14752 25 2017 2017 CD cord-005453-4057qib7 14752 26 . . . cord-005453-4057qib7 14753 1 They -PRON- PRP cord-005453-4057qib7 14753 2 are be VBP cord-005453-4057qib7 14753 3 divided divide VBN cord-005453-4057qib7 14753 4 into into IN cord-005453-4057qib7 14753 5 two two CD cord-005453-4057qib7 14753 6 groups group NNS cord-005453-4057qib7 14753 7 according accord VBG cord-005453-4057qib7 14753 8 to to IN cord-005453-4057qib7 14753 9 the the DT cord-005453-4057qib7 14753 10 concentration concentration NN cord-005453-4057qib7 14753 11 of of IN cord-005453-4057qib7 14753 12 DMSO DMSO NNP cord-005453-4057qib7 14753 13 used use VBN cord-005453-4057qib7 14753 14 in in IN cord-005453-4057qib7 14753 15 the the DT cord-005453-4057qib7 14753 16 freezing freezing NN cord-005453-4057qib7 14753 17 ( ( -LRB- cord-005453-4057qib7 14753 18 10 10 CD cord-005453-4057qib7 14753 19 % % NN cord-005453-4057qib7 14753 20 until until IN cord-005453-4057qib7 14753 21 September September NNP cord-005453-4057qib7 14753 22 2014 2014 CD cord-005453-4057qib7 14753 23 or or CC cord-005453-4057qib7 14753 24 5 5 CD cord-005453-4057qib7 14753 25 % % NN cord-005453-4057qib7 14753 26 since since IN cord-005453-4057qib7 14753 27 October October NNP cord-005453-4057qib7 14753 28 2014 2014 CD cord-005453-4057qib7 14753 29 ) ) -RRB- cord-005453-4057qib7 14753 30 . . . cord-005453-4057qib7 14754 1 The the DT cord-005453-4057qib7 14754 2 baseline baseline JJ cord-005453-4057qib7 14754 3 characteristics characteristic NNS cord-005453-4057qib7 14754 4 of of IN cord-005453-4057qib7 14754 5 the the DT cord-005453-4057qib7 14754 6 patients patient NNS cord-005453-4057qib7 14754 7 , , , cord-005453-4057qib7 14754 8 the the DT cord-005453-4057qib7 14754 9 infused infuse VBN cord-005453-4057qib7 14754 10 product product NN cord-005453-4057qib7 14754 11 and and CC cord-005453-4057qib7 14754 12 the the DT cord-005453-4057qib7 14754 13 graft graft NN cord-005453-4057qib7 14754 14 are be VBP cord-005453-4057qib7 14754 15 shown show VBN cord-005453-4057qib7 14754 16 in in IN cord-005453-4057qib7 14754 17 Table Table NNP cord-005453-4057qib7 14754 18 1 1 CD cord-005453-4057qib7 14754 19 . . . cord-005453-4057qib7 14755 1 The the DT cord-005453-4057qib7 14755 2 CD34 CD34 NNP cord-005453-4057qib7 14755 3 count count NN cord-005453-4057qib7 14755 4 was be VBD cord-005453-4057qib7 14755 5 performed perform VBN cord-005453-4057qib7 14755 6 by by IN cord-005453-4057qib7 14755 7 flow flow NN cord-005453-4057qib7 14755 8 cytometry cytometry NN cord-005453-4057qib7 14755 9 . . . cord-005453-4057qib7 14756 1 All all DT cord-005453-4057qib7 14756 2 freezings freezing NNS cord-005453-4057qib7 14756 3 were be VBD cord-005453-4057qib7 14756 4 performed perform VBN cord-005453-4057qib7 14756 5 with with IN cord-005453-4057qib7 14756 6 a a DT cord-005453-4057qib7 14756 7 biological biological JJ cord-005453-4057qib7 14756 8 freezer freezer NN cord-005453-4057qib7 14756 9 for for IN cord-005453-4057qib7 14756 10 programmed program VBN cord-005453-4057qib7 14756 11 controlled controlled JJ cord-005453-4057qib7 14756 12 rate rate NN cord-005453-4057qib7 14756 13 cryopreservation cryopreservation NN cord-005453-4057qib7 14756 14 and and CC cord-005453-4057qib7 14756 15 stored store VBN cord-005453-4057qib7 14756 16 in in IN cord-005453-4057qib7 14756 17 ultrafreezers ultrafreezer NNS cord-005453-4057qib7 14756 18 at at IN cord-005453-4057qib7 14756 19 -80ºC. -80ºC. JJS cord-005453-4057qib7 14756 20 Results result NNS cord-005453-4057qib7 14756 21 : : : cord-005453-4057qib7 14756 22 Both both DT cord-005453-4057qib7 14756 23 population population NN cord-005453-4057qib7 14756 24 groups group NNS cord-005453-4057qib7 14756 25 are be VBP cord-005453-4057qib7 14756 26 homogeneous homogeneous JJ cord-005453-4057qib7 14756 27 . . . cord-005453-4057qib7 14757 1 The the DT cord-005453-4057qib7 14757 2 t t NN cord-005453-4057qib7 14757 3 - - HYPH cord-005453-4057qib7 14757 4 test test NN cord-005453-4057qib7 14757 5 was be VBD cord-005453-4057qib7 14757 6 used use VBN cord-005453-4057qib7 14757 7 for for IN cord-005453-4057qib7 14757 8 statistical statistical JJ cord-005453-4057qib7 14757 9 analysis analysis NN cord-005453-4057qib7 14757 10 . . . cord-005453-4057qib7 14758 1 Regarding regard VBG cord-005453-4057qib7 14758 2 the the DT cord-005453-4057qib7 14758 3 CD34 CD34 NNP cord-005453-4057qib7 14758 4 + + CC cord-005453-4057qib7 14758 5 variable variable NN cord-005453-4057qib7 14758 6 , , , cord-005453-4057qib7 14758 7 no no DT cord-005453-4057qib7 14758 8 statistically statistically RB cord-005453-4057qib7 14758 9 significant significant JJ cord-005453-4057qib7 14758 10 differences difference NNS cord-005453-4057qib7 14758 11 were be VBD cord-005453-4057qib7 14758 12 observed observe VBN cord-005453-4057qib7 14758 13 ( ( -LRB- cord-005453-4057qib7 14758 14 p p NN cord-005453-4057qib7 14758 15 = = SYM cord-005453-4057qib7 14758 16 0.636 0.636 CD cord-005453-4057qib7 14758 17 ) ) -RRB- cord-005453-4057qib7 14758 18 . . . cord-005453-4057qib7 14759 1 Neither neither CC cord-005453-4057qib7 14759 2 for for IN cord-005453-4057qib7 14759 3 the the DT cord-005453-4057qib7 14759 4 variables variable NNS cord-005453-4057qib7 14759 5 leukocyte leukocyte NN cord-005453-4057qib7 14759 6 recovery recovery NN cord-005453-4057qib7 14759 7 and and CC cord-005453-4057qib7 14759 8 platelet platelet NN cord-005453-4057qib7 14759 9 recovery recovery NN cord-005453-4057qib7 14759 10 ( ( -LRB- cord-005453-4057qib7 14759 11 p p NN cord-005453-4057qib7 14759 12 = = SYM cord-005453-4057qib7 14759 13 0.178 0.178 CD cord-005453-4057qib7 14759 14 , , , cord-005453-4057qib7 14759 15 p p NN cord-005453-4057qib7 14759 16 = = SYM cord-005453-4057qib7 14759 17 0.991 0.991 CD cord-005453-4057qib7 14759 18 respectively respectively RB cord-005453-4057qib7 14759 19 ) ) -RRB- cord-005453-4057qib7 14759 20 . . . cord-005453-4057qib7 14760 1 The the DT cord-005453-4057qib7 14760 2 difference difference NN cord-005453-4057qib7 14760 3 in in IN cord-005453-4057qib7 14760 4 the the DT cord-005453-4057qib7 14760 5 variable variable JJ cord-005453-4057qib7 14760 6 Viability viability NN cord-005453-4057qib7 14760 7 is be VBZ cord-005453-4057qib7 14760 8 5.61 5.61 CD cord-005453-4057qib7 14760 9 units unit NNS cord-005453-4057qib7 14760 10 ( ( -LRB- cord-005453-4057qib7 14760 11 CI95 CI95 NNP cord-005453-4057qib7 14760 12 % % NN cord-005453-4057qib7 14760 13 : : : cord-005453-4057qib7 14760 14 [ [ -LRB- cord-005453-4057qib7 14760 15 0.61 0.61 CD cord-005453-4057qib7 14760 16 - - SYM cord-005453-4057qib7 14760 17 10.62 10.62 CD cord-005453-4057qib7 14760 18 ] ] -RRB- cord-005453-4057qib7 14760 19 ) ) -RRB- cord-005453-4057qib7 14760 20 and and CC cord-005453-4057qib7 14760 21 is be VBZ cord-005453-4057qib7 14760 22 statistically statistically RB cord-005453-4057qib7 14760 23 significant significant JJ cord-005453-4057qib7 14760 24 ( ( -LRB- cord-005453-4057qib7 14760 25 p p NN cord-005453-4057qib7 14760 26 = = SYM cord-005453-4057qib7 14760 27 0.028 0.028 CD cord-005453-4057qib7 14760 28 ) ) -RRB- cord-005453-4057qib7 14760 29 in in IN cord-005453-4057qib7 14760 30 favor favor NN cord-005453-4057qib7 14760 31 of of IN cord-005453-4057qib7 14760 32 DMSO DMSO NNP cord-005453-4057qib7 14760 33 5 5 CD cord-005453-4057qib7 14760 34 % % NN cord-005453-4057qib7 14760 35 . . . cord-005453-4057qib7 14761 1 Regarding regard VBG cord-005453-4057qib7 14761 2 adverse adverse JJ cord-005453-4057qib7 14761 3 effects effect NNS cord-005453-4057qib7 14761 4 , , , cord-005453-4057qib7 14761 5 100 100 CD cord-005453-4057qib7 14761 6 % % NN cord-005453-4057qib7 14761 7 ( ( -LRB- cord-005453-4057qib7 14761 8 n n NN cord-005453-4057qib7 14761 9 = = SYM cord-005453-4057qib7 14761 10 4 4 CD cord-005453-4057qib7 14761 11 ) ) -RRB- cord-005453-4057qib7 14761 12 of of IN cord-005453-4057qib7 14761 13 the the DT cord-005453-4057qib7 14761 14 serious serious JJ cord-005453-4057qib7 14761 15 adverse adverse JJ cord-005453-4057qib7 14761 16 reactions reaction NNS cord-005453-4057qib7 14761 17 occurred occur VBD cord-005453-4057qib7 14761 18 in in IN cord-005453-4057qib7 14761 19 the the DT cord-005453-4057qib7 14761 20 10 10 CD cord-005453-4057qib7 14761 21 % % NN cord-005453-4057qib7 14761 22 DMSO DMSO NNP cord-005453-4057qib7 14761 23 group group NN cord-005453-4057qib7 14761 24 ( ( -LRB- cord-005453-4057qib7 14761 25 hypotension hypotension NN cord-005453-4057qib7 14761 26 and and CC cord-005453-4057qib7 14761 27 seizures seizure NNS cord-005453-4057qib7 14761 28 ) ) -RRB- cord-005453-4057qib7 14761 29 . . . cord-005453-4057qib7 14762 1 The the DT cord-005453-4057qib7 14762 2 mild mild JJ cord-005453-4057qib7 14762 3 and and CC cord-005453-4057qib7 14762 4 moderate moderate JJ cord-005453-4057qib7 14762 5 ones one NNS cord-005453-4057qib7 14762 6 were be VBD cord-005453-4057qib7 14762 7 similar similar JJ cord-005453-4057qib7 14762 8 in in IN cord-005453-4057qib7 14762 9 both both DT cord-005453-4057qib7 14762 10 groups group NNS cord-005453-4057qib7 14762 11 , , , cord-005453-4057qib7 14762 12 most most RBS cord-005453-4057qib7 14762 13 were be VBD cord-005453-4057qib7 14762 14 mild mild JJ cord-005453-4057qib7 14762 15 nausea nausea NN cord-005453-4057qib7 14762 16 , , , cord-005453-4057qib7 14762 17 vomiting vomiting NN cord-005453-4057qib7 14762 18 and and CC cord-005453-4057qib7 14762 19 flushing flushing NN cord-005453-4057qib7 14762 20 . . . cord-005453-4057qib7 14763 1 Overall overall RB cord-005453-4057qib7 14763 2 , , , cord-005453-4057qib7 14763 3 no no DT cord-005453-4057qib7 14763 4 statistically statistically RB cord-005453-4057qib7 14763 5 significant significant JJ cord-005453-4057qib7 14763 6 differences difference NNS cord-005453-4057qib7 14763 7 were be VBD cord-005453-4057qib7 14763 8 observed observe VBN cord-005453-4057qib7 14763 9 due due IN cord-005453-4057qib7 14763 10 to to IN cord-005453-4057qib7 14763 11 the the DT cord-005453-4057qib7 14763 12 low low JJ cord-005453-4057qib7 14763 13 rate rate NN cord-005453-4057qib7 14763 14 of of IN cord-005453-4057qib7 14763 15 adverse adverse JJ cord-005453-4057qib7 14763 16 effects effect NNS cord-005453-4057qib7 14763 17 found find VBN cord-005453-4057qib7 14763 18 . . . cord-005453-4057qib7 14764 1 PATIENTS patient NNS cord-005453-4057qib7 14764 2 Starting start VBG cord-005453-4057qib7 14764 3 with with IN cord-005453-4057qib7 14764 4 2014 2014 CD cord-005453-4057qib7 14764 5 until until IN cord-005453-4057qib7 14764 6 October October NNP cord-005453-4057qib7 14764 7 2018 2018 CD cord-005453-4057qib7 14765 1 , , , cord-005453-4057qib7 14765 2 total total NN cord-005453-4057qib7 14765 3 of of IN cord-005453-4057qib7 14765 4 414 414 CD cord-005453-4057qib7 14765 5 patients patient NNS cord-005453-4057qib7 14765 6 attempted attempt VBD cord-005453-4057qib7 14765 7 collection collection NN cord-005453-4057qib7 14765 8 of of IN cord-005453-4057qib7 14765 9 autologous autologous JJ cord-005453-4057qib7 14765 10 PBSCs pbsc NNS cord-005453-4057qib7 14765 11 , , , cord-005453-4057qib7 14765 12 and and CC cord-005453-4057qib7 14765 13 38 38 CD cord-005453-4057qib7 14765 14 poor poor JJ cord-005453-4057qib7 14765 15 mobilizers mobilizer NNS cord-005453-4057qib7 14765 16 recieved recieve VBD cord-005453-4057qib7 14765 17 plerixafor plerixafor NN cord-005453-4057qib7 14765 18 during during IN cord-005453-4057qib7 14765 19 first first JJ cord-005453-4057qib7 14765 20 mobilization mobilization NN cord-005453-4057qib7 14765 21 cycle cycle NN cord-005453-4057qib7 14765 22 . . . cord-005453-4057qib7 14766 1 in in IN cord-005453-4057qib7 14766 2 total total NN cord-005453-4057qib7 14766 3 , , , cord-005453-4057qib7 14766 4 9 9 CD cord-005453-4057qib7 14766 5 patients patient NNS cord-005453-4057qib7 14766 6 required require VBD cord-005453-4057qib7 14766 7 repeated repeated JJ cord-005453-4057qib7 14766 8 mobilization mobilization NN cord-005453-4057qib7 14766 9 cycles cycle NNS cord-005453-4057qib7 14766 10 ( ( -LRB- cord-005453-4057qib7 14766 11 2,2 2,2 CD cord-005453-4057qib7 14766 12 % % NN cord-005453-4057qib7 14766 13 ) ) -RRB- cord-005453-4057qib7 14766 14 of of IN cord-005453-4057qib7 14766 15 which which WDT cord-005453-4057qib7 14766 16 6 6 CD cord-005453-4057qib7 14766 17 were be VBD cord-005453-4057qib7 14766 18 from from IN cord-005453-4057qib7 14766 19 the the DT cord-005453-4057qib7 14766 20 plerixafor plerixafor NN cord-005453-4057qib7 14766 21 group group NN cord-005453-4057qib7 14766 22 . . . cord-005453-4057qib7 14767 1 In in IN cord-005453-4057qib7 14767 2 total total JJ cord-005453-4057qib7 14767 3 42 42 CD cord-005453-4057qib7 14767 4 patients patient NNS cord-005453-4057qib7 14767 5 recieved recieve VBD cord-005453-4057qib7 14767 6 pleriksafor pleriksafor NN cord-005453-4057qib7 14767 7 ; ; : cord-005453-4057qib7 14767 8 23 23 CD cord-005453-4057qib7 14767 9 females female NNS cord-005453-4057qib7 14767 10 and and CC cord-005453-4057qib7 14767 11 19 19 CD cord-005453-4057qib7 14767 12 males male NNS cord-005453-4057qib7 14767 13 , , , cord-005453-4057qib7 14767 14 median median JJ cord-005453-4057qib7 14767 15 age age NN cord-005453-4057qib7 14767 16 58 58 CD cord-005453-4057qib7 14767 17 ( ( -LRB- cord-005453-4057qib7 14767 18 8 8 CD cord-005453-4057qib7 14767 19 - - SYM cord-005453-4057qib7 14767 20 71 71 CD cord-005453-4057qib7 14767 21 ) ) -RRB- cord-005453-4057qib7 14767 22 with with IN cord-005453-4057qib7 14767 23 following follow VBG cord-005453-4057qib7 14767 24 diagnoses diagnosis NNS cord-005453-4057qib7 14767 25 : : : cord-005453-4057qib7 14767 26 28 28 CD cord-005453-4057qib7 14767 27 NHL NHL NNP cord-005453-4057qib7 14767 28 , , , cord-005453-4057qib7 14767 29 5 5 CD cord-005453-4057qib7 14767 30 MH MH NNP cord-005453-4057qib7 14767 31 , , , cord-005453-4057qib7 14767 32 5 5 CD cord-005453-4057qib7 14767 33 multiple multiple JJ cord-005453-4057qib7 14767 34 myeloma myeloma NN cord-005453-4057qib7 14767 35 , , , cord-005453-4057qib7 14767 36 1 1 CD cord-005453-4057qib7 14767 37 neuroblastoma neuroblastoma NN cord-005453-4057qib7 14767 38 , , , cord-005453-4057qib7 14767 39 1 1 CD cord-005453-4057qib7 14767 40 nephroblastoma nephroblastoma NNS cord-005453-4057qib7 14767 41 , , , cord-005453-4057qib7 14767 42 1 1 CD cord-005453-4057qib7 14767 43 sarcoma sarcoma NN cord-005453-4057qib7 14767 44 Ewing Ewing NNP cord-005453-4057qib7 14767 45 and and CC cord-005453-4057qib7 14767 46 1 1 CD cord-005453-4057qib7 14767 47 seminoma seminoma NN cord-005453-4057qib7 14767 48 . . . cord-005453-4057qib7 14768 1 Of of IN cord-005453-4057qib7 14768 2 6 6 CD cord-005453-4057qib7 14768 3 repeated repeat VBN cord-005453-4057qib7 14768 4 mobilizations mobilization NNS cord-005453-4057qib7 14768 5 with with IN cord-005453-4057qib7 14768 6 plerixafor plerixafor NN cord-005453-4057qib7 14768 7 , , , cord-005453-4057qib7 14768 8 2 2 CD cord-005453-4057qib7 14768 9 patients patient NNS cord-005453-4057qib7 14768 10 ( ( -LRB- cord-005453-4057qib7 14768 11 33,3 33,3 CD cord-005453-4057qib7 14768 12 % % NN cord-005453-4057qib7 14768 13 ) ) -RRB- cord-005453-4057qib7 14768 14 still still RB cord-005453-4057qib7 14768 15 failed fail VBD cord-005453-4057qib7 14768 16 to to TO cord-005453-4057qib7 14768 17 collect collect VB cord-005453-4057qib7 14768 18 adequate adequate JJ cord-005453-4057qib7 14768 19 transplant transplant NN cord-005453-4057qib7 14768 20 . . . cord-005453-4057qib7 14769 1 In in IN cord-005453-4057qib7 14769 2 this this DT cord-005453-4057qib7 14769 3 period period NN cord-005453-4057qib7 14769 4 we -PRON- PRP cord-005453-4057qib7 14769 5 had have VBD cord-005453-4057qib7 14769 6 altogether altogether RB cord-005453-4057qib7 14769 7 3 3 CD cord-005453-4057qib7 14769 8 unsuccessful unsuccessful JJ cord-005453-4057qib7 14769 9 mobilizations mobilization NNS cord-005453-4057qib7 14769 10 ( ( -LRB- cord-005453-4057qib7 14769 11 33,3 33,3 CD cord-005453-4057qib7 14769 12 % % NN cord-005453-4057qib7 14769 13 in in IN cord-005453-4057qib7 14769 14 repeated repeat VBN cord-005453-4057qib7 14769 15 cycles cycle NNS cord-005453-4057qib7 14769 16 , , , cord-005453-4057qib7 14769 17 0,72 0,72 CD cord-005453-4057qib7 14769 18 % % NN cord-005453-4057qib7 14769 19 in in IN cord-005453-4057qib7 14769 20 total total NN cord-005453-4057qib7 14769 21 ) ) -RRB- cord-005453-4057qib7 14769 22 . . . cord-005453-4057qib7 14770 1 This this DT cord-005453-4057qib7 14770 2 group group NN cord-005453-4057qib7 14770 3 of of IN cord-005453-4057qib7 14770 4 patients patient NNS cord-005453-4057qib7 14770 5 consisted consist VBD cord-005453-4057qib7 14770 6 of of IN cord-005453-4057qib7 14770 7 1 1 CD cord-005453-4057qib7 14770 8 male male NN cord-005453-4057qib7 14770 9 and and CC cord-005453-4057qib7 14770 10 2 2 CD cord-005453-4057qib7 14770 11 female female JJ cord-005453-4057qib7 14770 12 patients patient NNS cord-005453-4057qib7 14770 13 , , , cord-005453-4057qib7 14770 14 median median JJ cord-005453-4057qib7 14770 15 age age NN cord-005453-4057qib7 14770 16 42 42 CD cord-005453-4057qib7 14770 17 ( ( -LRB- cord-005453-4057qib7 14770 18 33 33 CD cord-005453-4057qib7 14770 19 - - SYM cord-005453-4057qib7 14770 20 58 58 CD cord-005453-4057qib7 14770 21 ) ) -RRB- cord-005453-4057qib7 14770 22 , , , cord-005453-4057qib7 14770 23 diagnosis diagnosis NN cord-005453-4057qib7 14770 24 of of IN cord-005453-4057qib7 14770 25 NHL NHL NNP cord-005453-4057qib7 14770 26 and and CC cord-005453-4057qib7 14770 27 failure failure NN cord-005453-4057qib7 14770 28 to to TO cord-005453-4057qib7 14770 29 collect collect VB cord-005453-4057qib7 14770 30 after after IN cord-005453-4057qib7 14770 31 4 4 CD cord-005453-4057qib7 14770 32 leukapheresis leukapheresis NN cord-005453-4057qib7 14770 33 procedures procedure NNS cord-005453-4057qib7 14770 34 each each DT cord-005453-4057qib7 14770 35 . . . cord-005453-4057qib7 14771 1 Median median JJ cord-005453-4057qib7 14771 2 number number NN cord-005453-4057qib7 14771 3 of of IN cord-005453-4057qib7 14771 4 leukapheresis leukapheresis NN cord-005453-4057qib7 14771 5 needed need VBN cord-005453-4057qib7 14771 6 for for IN cord-005453-4057qib7 14771 7 adequate adequate JJ cord-005453-4057qib7 14771 8 collection collection NN cord-005453-4057qib7 14771 9 was be VBD cord-005453-4057qib7 14771 10 2 2 CD cord-005453-4057qib7 14771 11 with with IN cord-005453-4057qib7 14771 12 preemtive preemtive JJ cord-005453-4057qib7 14771 13 plerixafor plerixafor NN cord-005453-4057qib7 14771 14 use use NN cord-005453-4057qib7 14771 15 , , , cord-005453-4057qib7 14771 16 and and CC cord-005453-4057qib7 14771 17 4 4 CD cord-005453-4057qib7 14771 18 in in IN cord-005453-4057qib7 14771 19 repeated repeat VBN cord-005453-4057qib7 14771 20 mobilizations mobilization NNS cord-005453-4057qib7 14771 21 . . . cord-005453-4057qib7 14772 1 Conclusions conclusion NNS cord-005453-4057qib7 14772 2 : : : cord-005453-4057qib7 14773 1 Our -PRON- PRP$ cord-005453-4057qib7 14773 2 expirience expirience NN cord-005453-4057qib7 14773 3 shows show VBZ cord-005453-4057qib7 14773 4 that that IN cord-005453-4057qib7 14773 5 preemtive preemtive JJ cord-005453-4057qib7 14773 6 use use NN cord-005453-4057qib7 14773 7 of of IN cord-005453-4057qib7 14773 8 plerixafor plerixafor NN cord-005453-4057qib7 14773 9 in in IN cord-005453-4057qib7 14773 10 poor poor JJ cord-005453-4057qib7 14773 11 mobilizers mobilizer NNS cord-005453-4057qib7 14773 12 is be VBZ cord-005453-4057qib7 14773 13 efficient efficient JJ cord-005453-4057qib7 14773 14 and and CC cord-005453-4057qib7 14773 15 has have VBZ cord-005453-4057qib7 14773 16 enhached enhache VBN cord-005453-4057qib7 14773 17 success success NN cord-005453-4057qib7 14773 18 of of IN cord-005453-4057qib7 14773 19 the the DT cord-005453-4057qib7 14773 20 PBSC PBSC NNP cord-005453-4057qib7 14773 21 collections collection NNS cord-005453-4057qib7 14773 22 . . . cord-005453-4057qib7 14774 1 Due due IN cord-005453-4057qib7 14774 2 to to IN cord-005453-4057qib7 14774 3 drug drug NN cord-005453-4057qib7 14774 4 high high JJ cord-005453-4057qib7 14774 5 cost cost NN cord-005453-4057qib7 14774 6 each each DT cord-005453-4057qib7 14774 7 institution institution NN cord-005453-4057qib7 14774 8 needs need VBZ cord-005453-4057qib7 14774 9 to to TO cord-005453-4057qib7 14774 10 develop develop VB cord-005453-4057qib7 14774 11 its -PRON- PRP$ cord-005453-4057qib7 14774 12 own own JJ cord-005453-4057qib7 14774 13 algorythm algorythm NN cord-005453-4057qib7 14774 14 in in IN cord-005453-4057qib7 14774 15 management management NN cord-005453-4057qib7 14774 16 of of IN cord-005453-4057qib7 14774 17 poor poor JJ cord-005453-4057qib7 14774 18 mobilizers mobilizer NNS cord-005453-4057qib7 14774 19 . . . cord-005453-4057qib7 14775 1 The the DT cord-005453-4057qib7 14775 2 factors factor NNS cord-005453-4057qib7 14775 3 contributing contribute VBG cord-005453-4057qib7 14775 4 to to IN cord-005453-4057qib7 14775 5 plerixafor plerixafor NN cord-005453-4057qib7 14775 6 mobilization mobilization NN cord-005453-4057qib7 14775 7 failure failure NN cord-005453-4057qib7 14775 8 still still RB cord-005453-4057qib7 14775 9 need need VBP cord-005453-4057qib7 14775 10 to to TO cord-005453-4057qib7 14775 11 be be VB cord-005453-4057qib7 14775 12 elucidated elucidate VBN cord-005453-4057qib7 14775 13 . . . cord-005453-4057qib7 14776 1 Disclosure disclosure NN cord-005453-4057qib7 14776 2 : : : cord-005453-4057qib7 14776 3 Nothing nothing NN cord-005453-4057qib7 14776 4 to to TO cord-005453-4057qib7 14776 5 declare declare VB cord-005453-4057qib7 14776 6 . . . cord-005453-4057qib7 14777 1 Platelets platelet NNS cord-005453-4057qib7 14777 2 recovered recover VBD cord-005453-4057qib7 14777 3 from from IN cord-005453-4057qib7 14777 4 mobilized mobilize VBN cord-005453-4057qib7 14777 5 leukapheresis leukapheresis NN cord-005453-4057qib7 14777 6 units unit NNS cord-005453-4057qib7 14777 7 obtained obtain VBN cord-005453-4057qib7 14777 8 from from IN cord-005453-4057qib7 14777 9 HLA HLA NNP cord-005453-4057qib7 14777 10 - - HYPH cord-005453-4057qib7 14777 11 haploidentical haploidentical JJ cord-005453-4057qib7 14777 12 donors donor NNS cord-005453-4057qib7 14777 13 fulfill fulfill VBP cord-005453-4057qib7 14777 14 the the DT cord-005453-4057qib7 14777 15 criteria criterion NNS cord-005453-4057qib7 14777 16 of of IN cord-005453-4057qib7 14777 17 a a DT cord-005453-4057qib7 14777 18 conventional conventional JJ cord-005453-4057qib7 14777 19 hemocomponent hemocomponent NN cord-005453-4057qib7 14777 20 and and CC cord-005453-4057qib7 14777 21 can can MD cord-005453-4057qib7 14777 22 be be VB cord-005453-4057qib7 14777 23 used use VBN cord-005453-4057qib7 14777 24 for for IN cord-005453-4057qib7 14777 25 transfusion transfusion NN cord-005453-4057qib7 14777 26 Background background NN cord-005453-4057qib7 14777 27 : : : cord-005453-4057qib7 14777 28 Central central JJ cord-005453-4057qib7 14777 29 venous venous JJ cord-005453-4057qib7 14777 30 catheter catheter NN cord-005453-4057qib7 14777 31 ( ( -LRB- cord-005453-4057qib7 14777 32 CVC CVC NNP cord-005453-4057qib7 14777 33 ) ) -RRB- cord-005453-4057qib7 14777 34 related relate VBN cord-005453-4057qib7 14777 35 complications complication NNS cord-005453-4057qib7 14777 36 may may MD cord-005453-4057qib7 14777 37 lead lead VB cord-005453-4057qib7 14777 38 to to IN cord-005453-4057qib7 14777 39 high high JJ cord-005453-4057qib7 14777 40 morbidity morbidity NN cord-005453-4057qib7 14777 41 and and CC cord-005453-4057qib7 14777 42 mortality mortality NN cord-005453-4057qib7 14777 43 . . . cord-005453-4057qib7 14778 1 Unlike unlike IN cord-005453-4057qib7 14778 2 CVC CVC NNP cord-005453-4057qib7 14778 3 , , , cord-005453-4057qib7 14778 4 peripheral peripheral JJ cord-005453-4057qib7 14778 5 cannulation cannulation NN cord-005453-4057qib7 14778 6 offers offer VBZ cord-005453-4057qib7 14778 7 a a DT cord-005453-4057qib7 14778 8 quick quick JJ cord-005453-4057qib7 14778 9 and and CC cord-005453-4057qib7 14778 10 inexpensive inexpensive JJ cord-005453-4057qib7 14778 11 method method NN cord-005453-4057qib7 14778 12 for for IN cord-005453-4057qib7 14778 13 safe safe JJ cord-005453-4057qib7 14778 14 and and CC cord-005453-4057qib7 14778 15 non non JJ cord-005453-4057qib7 14778 16 - - JJ cord-005453-4057qib7 14778 17 traumatic traumatic JJ cord-005453-4057qib7 14778 18 vascular vascular JJ cord-005453-4057qib7 14778 19 access access NN cord-005453-4057qib7 14778 20 ( ( -LRB- cord-005453-4057qib7 14778 21 VA VA NNP cord-005453-4057qib7 14778 22 ) ) -RRB- cord-005453-4057qib7 14779 1 thus thus RB cord-005453-4057qib7 14779 2 its -PRON- PRP$ cord-005453-4057qib7 14779 3 utilization utilization NN cord-005453-4057qib7 14779 4 is be VBZ cord-005453-4057qib7 14779 5 strongly strongly RB cord-005453-4057qib7 14779 6 recommended recommend VBN cord-005453-4057qib7 14779 7 whenever whenever WRB cord-005453-4057qib7 14779 8 possible possible JJ cord-005453-4057qib7 14779 9 . . . cord-005453-4057qib7 14780 1 The the DT cord-005453-4057qib7 14780 2 ultrasound ultrasound NN cord-005453-4057qib7 14780 3 ( ( -LRB- cord-005453-4057qib7 14780 4 US US NNP cord-005453-4057qib7 14780 5 ) ) -RRB- cord-005453-4057qib7 14780 6 guidance guidance NN cord-005453-4057qib7 14780 7 for for IN cord-005453-4057qib7 14780 8 acquiring acquire VBG cord-005453-4057qib7 14780 9 peripheral peripheral JJ cord-005453-4057qib7 14780 10 VA VA NNP cord-005453-4057qib7 14780 11 is be VBZ cord-005453-4057qib7 14780 12 a a DT cord-005453-4057qib7 14780 13 useful useful JJ cord-005453-4057qib7 14780 14 tool tool NN cord-005453-4057qib7 14780 15 for for IN cord-005453-4057qib7 14780 16 reduction reduction NN cord-005453-4057qib7 14780 17 or or CC cord-005453-4057qib7 14780 18 elimination elimination NN cord-005453-4057qib7 14780 19 of of IN cord-005453-4057qib7 14780 20 the the DT cord-005453-4057qib7 14780 21 need need NN cord-005453-4057qib7 14780 22 of of IN cord-005453-4057qib7 14780 23 using use VBG cord-005453-4057qib7 14780 24 CVC CVC NNP cord-005453-4057qib7 14780 25 for for IN cord-005453-4057qib7 14780 26 stem stem NN cord-005453-4057qib7 14780 27 cells cell NNS cord-005453-4057qib7 14780 28 collection collection NN cord-005453-4057qib7 14780 29 . . . cord-005453-4057qib7 14781 1 We -PRON- PRP cord-005453-4057qib7 14781 2 have have VBP cord-005453-4057qib7 14781 3 made make VBN cord-005453-4057qib7 14781 4 an an DT cord-005453-4057qib7 14781 5 attempt attempt NN cord-005453-4057qib7 14781 6 to to TO cord-005453-4057qib7 14781 7 introduce introduce VB cord-005453-4057qib7 14781 8 US US NNP cord-005453-4057qib7 14781 9 method method NN cord-005453-4057qib7 14781 10 in in IN cord-005453-4057qib7 14781 11 our -PRON- PRP$ cord-005453-4057qib7 14781 12 apheresis apheresis NN cord-005453-4057qib7 14781 13 unit unit NN cord-005453-4057qib7 14781 14 having have VBG cord-005453-4057qib7 14781 15 no no DT cord-005453-4057qib7 14781 16 previous previous JJ cord-005453-4057qib7 14781 17 experience experience NN cord-005453-4057qib7 14781 18 with with IN cord-005453-4057qib7 14781 19 US US NNP cord-005453-4057qib7 14781 20 devices device NNS cord-005453-4057qib7 14781 21 . . . cord-005453-4057qib7 14782 1 The the DT cord-005453-4057qib7 14782 2 aim aim NN cord-005453-4057qib7 14782 3 of of IN cord-005453-4057qib7 14782 4 the the DT cord-005453-4057qib7 14782 5 study study NN cord-005453-4057qib7 14782 6 was be VBD cord-005453-4057qib7 14782 7 to to TO cord-005453-4057qib7 14782 8 measure measure VB cord-005453-4057qib7 14782 9 the the DT cord-005453-4057qib7 14782 10 decrease decrease NN cord-005453-4057qib7 14782 11 of of IN cord-005453-4057qib7 14782 12 CVC CVC NNP cord-005453-4057qib7 14782 13 insertions insertion NNS cord-005453-4057qib7 14782 14 after after IN cord-005453-4057qib7 14782 15 introducing introduce VBG cord-005453-4057qib7 14782 16 US US NNP cord-005453-4057qib7 14782 17 and and CC cord-005453-4057qib7 14782 18 evaluate evaluate VB cord-005453-4057qib7 14782 19 the the DT cord-005453-4057qib7 14782 20 quality quality NN cord-005453-4057qib7 14782 21 of of IN cord-005453-4057qib7 14782 22 VA VA NNP cord-005453-4057qib7 14782 23 by by IN cord-005453-4057qib7 14782 24 comparing compare VBG cord-005453-4057qib7 14782 25 average average JJ cord-005453-4057qib7 14782 26 flow flow NN cord-005453-4057qib7 14782 27 rate rate NN cord-005453-4057qib7 14782 28 and and CC cord-005453-4057qib7 14782 29 confirming confirm VBG cord-005453-4057qib7 14782 30 that that IN cord-005453-4057qib7 14782 31 the the DT cord-005453-4057qib7 14782 32 desired desire VBN cord-005453-4057qib7 14782 33 blood blood NN cord-005453-4057qib7 14782 34 volume volume NN cord-005453-4057qib7 14782 35 could could MD cord-005453-4057qib7 14782 36 be be VB cord-005453-4057qib7 14782 37 processed process VBN cord-005453-4057qib7 14782 38 . . . cord-005453-4057qib7 14783 1 Methods method NNS cord-005453-4057qib7 14783 2 : : : cord-005453-4057qib7 14784 1 The the DT cord-005453-4057qib7 14784 2 theoretical theoretical JJ cord-005453-4057qib7 14784 3 education education NN cord-005453-4057qib7 14784 4 involved involve VBD cord-005453-4057qib7 14784 5 a a DT cord-005453-4057qib7 14784 6 free free JJ cord-005453-4057qib7 14784 7 elearning elearning NN cord-005453-4057qib7 14784 8 course course NN cord-005453-4057qib7 14784 9 in in IN cord-005453-4057qib7 14784 10 peripheral peripheral JJ cord-005453-4057qib7 14784 11 ultrasound ultrasound NN cord-005453-4057qib7 14784 12 - - HYPH cord-005453-4057qib7 14784 13 guided guide VBN cord-005453-4057qib7 14784 14 VA VA NNP cord-005453-4057qib7 14784 15 ( ( -LRB- cord-005453-4057qib7 14784 16 PUGVA PUGVA NNP cord-005453-4057qib7 14784 17 , , , cord-005453-4057qib7 14784 18 USabcd USabcd NNP cord-005453-4057qib7 14784 19 , , , cord-005453-4057qib7 14784 20 Aarhus Aarhus NNP cord-005453-4057qib7 14784 21 , , , cord-005453-4057qib7 14784 22 Denmark Denmark NNP cord-005453-4057qib7 14784 23 ) ) -RRB- cord-005453-4057qib7 14784 24 . . . cord-005453-4057qib7 14785 1 Subsequently subsequently RB cord-005453-4057qib7 14785 2 , , , cord-005453-4057qib7 14785 3 the the DT cord-005453-4057qib7 14785 4 personnel personnel NNS cord-005453-4057qib7 14785 5 have have VBP cord-005453-4057qib7 14785 6 implemented implement VBN cord-005453-4057qib7 14785 7 knowledge knowledge NN cord-005453-4057qib7 14785 8 in in IN cord-005453-4057qib7 14785 9 practical practical JJ cord-005453-4057qib7 14785 10 training training NN cord-005453-4057qib7 14785 11 on on IN cord-005453-4057qib7 14785 12 gelatine gelatine NN cord-005453-4057qib7 14785 13 and and CC cord-005453-4057qib7 14785 14 silicone silicone NN cord-005453-4057qib7 14785 15 phantoms phantom NNS cord-005453-4057qib7 14785 16 and and CC cord-005453-4057qib7 14785 17 healthy healthy JJ cord-005453-4057qib7 14785 18 volunteers volunteer NNS cord-005453-4057qib7 14785 19 . . . cord-005453-4057qib7 14786 1 The the DT cord-005453-4057qib7 14786 2 practical practical JJ cord-005453-4057qib7 14786 3 activities activity NNS cord-005453-4057qib7 14786 4 also also RB cord-005453-4057qib7 14786 5 included include VBD cord-005453-4057qib7 14786 6 a a DT cord-005453-4057qib7 14786 7 fiveday fiveday NN cord-005453-4057qib7 14786 8 course course NN cord-005453-4057qib7 14786 9 in in IN cord-005453-4057qib7 14786 10 an an DT cord-005453-4057qib7 14786 11 apheresis apheresis NN cord-005453-4057qib7 14786 12 centre centre NN cord-005453-4057qib7 14786 13 with with IN cord-005453-4057qib7 14786 14 US US NNP cord-005453-4057qib7 14786 15 - - HYPH cord-005453-4057qib7 14786 16 guided guide VBN cord-005453-4057qib7 14786 17 cannulation cannulation NN cord-005453-4057qib7 14786 18 experience experience NN cord-005453-4057qib7 14786 19 . . . cord-005453-4057qib7 14787 1 The the DT cord-005453-4057qib7 14787 2 details detail NNS cord-005453-4057qib7 14787 3 concerning concern VBG cord-005453-4057qib7 14787 4 VA VA NNP cord-005453-4057qib7 14787 5 were be VBD cord-005453-4057qib7 14787 6 recorded record VBN cord-005453-4057qib7 14787 7 , , , cord-005453-4057qib7 14787 8 including include VBG cord-005453-4057qib7 14787 9 VA VA NNP cord-005453-4057qib7 14787 10 site site NN cord-005453-4057qib7 14787 11 , , , cord-005453-4057qib7 14787 12 cannula cannula NN cord-005453-4057qib7 14787 13 size size NN cord-005453-4057qib7 14787 14 , , , cord-005453-4057qib7 14787 15 average average JJ cord-005453-4057qib7 14787 16 inlet inlet NN cord-005453-4057qib7 14787 17 flow flow NN cord-005453-4057qib7 14787 18 rate rate NN cord-005453-4057qib7 14787 19 , , , cord-005453-4057qib7 14787 20 number number NN cord-005453-4057qib7 14787 21 of of IN cord-005453-4057qib7 14787 22 inlet inlet NN cord-005453-4057qib7 14787 23 pressure pressure NN cord-005453-4057qib7 14787 24 alarms alarm NNS cord-005453-4057qib7 14787 25 reported report VBN cord-005453-4057qib7 14787 26 by by IN cord-005453-4057qib7 14787 27 the the DT cord-005453-4057qib7 14787 28 apheresis apheresis NN cord-005453-4057qib7 14787 29 device device NN cord-005453-4057qib7 14787 30 . . . cord-005453-4057qib7 14788 1 The the DT cord-005453-4057qib7 14788 2 procedure procedure NN cord-005453-4057qib7 14788 3 details detail NNS cord-005453-4057qib7 14788 4 where where WRB cord-005453-4057qib7 14788 5 traditional traditional JJ cord-005453-4057qib7 14788 6 approach approach NN cord-005453-4057qib7 14788 7 was be VBD cord-005453-4057qib7 14788 8 applied apply VBN cord-005453-4057qib7 14788 9 i.e. i.e. FW cord-005453-4057qib7 14788 10 palpable palpable JJ cord-005453-4057qib7 14788 11 cannulation cannulation NN cord-005453-4057qib7 14788 12 and and CC cord-005453-4057qib7 14788 13 CVCs CVCs NNP cord-005453-4057qib7 14788 14 have have VBP cord-005453-4057qib7 14788 15 been be VBN cord-005453-4057qib7 14788 16 collected collect VBN cord-005453-4057qib7 14788 17 . . . cord-005453-4057qib7 14789 1 Similarly similarly RB cord-005453-4057qib7 14789 2 , , , cord-005453-4057qib7 14789 3 the the DT cord-005453-4057qib7 14789 4 necessary necessary JJ cord-005453-4057qib7 14789 5 data datum NNS cord-005453-4057qib7 14789 6 for for IN cord-005453-4057qib7 14789 7 procedures procedure NNS cord-005453-4057qib7 14789 8 where where WRB cord-005453-4057qib7 14789 9 veins vein NNS cord-005453-4057qib7 14789 10 were be VBD cord-005453-4057qib7 14789 11 assessed assess VBN cord-005453-4057qib7 14789 12 with with IN cord-005453-4057qib7 14789 13 ultrasound ultrasound NN cord-005453-4057qib7 14789 14 prior prior RB cord-005453-4057qib7 14789 15 to to IN cord-005453-4057qib7 14789 16 apheresis apheresis NN cord-005453-4057qib7 14789 17 were be VBD cord-005453-4057qib7 14789 18 recorded record VBN cord-005453-4057qib7 14789 19 . . . cord-005453-4057qib7 14790 1 Results result NNS cord-005453-4057qib7 14790 2 : : : cord-005453-4057qib7 14790 3 Before before IN cord-005453-4057qib7 14790 4 introducing introduce VBG cord-005453-4057qib7 14790 5 ultrasonography ultrasonography NN cord-005453-4057qib7 14790 6 , , , cord-005453-4057qib7 14790 7 58 58 CD cord-005453-4057qib7 14790 8 stem stem NN cord-005453-4057qib7 14790 9 cell cell NN cord-005453-4057qib7 14790 10 collections collection NNS cord-005453-4057qib7 14790 11 have have VBP cord-005453-4057qib7 14790 12 been be VBN cord-005453-4057qib7 14790 13 performed perform VBN cord-005453-4057qib7 14790 14 in in IN cord-005453-4057qib7 14790 15 46 46 CD cord-005453-4057qib7 14790 16 patients patient NNS cord-005453-4057qib7 14790 17 . . . cord-005453-4057qib7 14791 1 Of of IN cord-005453-4057qib7 14791 2 all all PDT cord-005453-4057qib7 14791 3 these these DT cord-005453-4057qib7 14791 4 procedures procedure NNS cord-005453-4057qib7 14791 5 , , , cord-005453-4057qib7 14791 6 18 18 CD cord-005453-4057qib7 14791 7 were be VBD cord-005453-4057qib7 14791 8 accomplished accomplish VBN cord-005453-4057qib7 14791 9 with with IN cord-005453-4057qib7 14791 10 CVC CVC NNP cord-005453-4057qib7 14791 11 ( ( -LRB- cord-005453-4057qib7 14791 12 31 31 CD cord-005453-4057qib7 14791 13 % % NN cord-005453-4057qib7 14791 14 ) ) -RRB- cord-005453-4057qib7 14791 15 and and CC cord-005453-4057qib7 14791 16 40 40 CD cord-005453-4057qib7 14791 17 with with IN cord-005453-4057qib7 14791 18 peripheral peripheral JJ cord-005453-4057qib7 14791 19 VA VA NNP cord-005453-4057qib7 14791 20 ( ( -LRB- cord-005453-4057qib7 14791 21 69 69 CD cord-005453-4057qib7 14791 22 % % NN cord-005453-4057qib7 14791 23 ) ) -RRB- cord-005453-4057qib7 14791 24 . . . cord-005453-4057qib7 14792 1 Median median JJ cord-005453-4057qib7 14792 2 cubital cubital JJ cord-005453-4057qib7 14792 3 vein vein NN cord-005453-4057qib7 14792 4 was be VBD cord-005453-4057qib7 14792 5 the the DT cord-005453-4057qib7 14792 6 vessel vessel NN cord-005453-4057qib7 14792 7 of of IN cord-005453-4057qib7 14792 8 choice choice NN cord-005453-4057qib7 14792 9 . . . cord-005453-4057qib7 14793 1 Out out IN cord-005453-4057qib7 14793 2 of of IN cord-005453-4057qib7 14793 3 the the DT cord-005453-4057qib7 14793 4 40 40 CD cord-005453-4057qib7 14793 5 peripheral peripheral JJ cord-005453-4057qib7 14793 6 VA VA NNP cord-005453-4057qib7 14793 7 procedures procedure NNS cord-005453-4057qib7 14793 8 , , , cord-005453-4057qib7 14793 9 14 14 CD cord-005453-4057qib7 14793 10 ( ( -LRB- cord-005453-4057qib7 14793 11 35 35 CD cord-005453-4057qib7 14793 12 % % NN cord-005453-4057qib7 14793 13 ) ) -RRB- cord-005453-4057qib7 14793 14 were be VBD cord-005453-4057qib7 14793 15 problematic problematic JJ cord-005453-4057qib7 14793 16 , , , cord-005453-4057qib7 14793 17 with with IN cord-005453-4057qib7 14793 18 10 10 CD cord-005453-4057qib7 14793 19 or or CC cord-005453-4057qib7 14793 20 more more JJR cord-005453-4057qib7 14793 21 inlet inlet NN cord-005453-4057qib7 14793 22 pressure pressure NN cord-005453-4057qib7 14793 23 alarms alarm NNS cord-005453-4057qib7 14793 24 during during IN cord-005453-4057qib7 14793 25 every every DT cord-005453-4057qib7 14793 26 procedure procedure NN cord-005453-4057qib7 14793 27 . . . cord-005453-4057qib7 14794 1 After after IN cord-005453-4057qib7 14794 2 the the DT cord-005453-4057qib7 14794 3 training training NN cord-005453-4057qib7 14794 4 stage stage NN cord-005453-4057qib7 14794 5 , , , cord-005453-4057qib7 14794 6 34 34 CD cord-005453-4057qib7 14794 7 collection collection NN cord-005453-4057qib7 14794 8 procedures procedure NNS cord-005453-4057qib7 14794 9 were be VBD cord-005453-4057qib7 14794 10 performed perform VBN cord-005453-4057qib7 14794 11 in in IN cord-005453-4057qib7 14794 12 25 25 CD cord-005453-4057qib7 14794 13 patients patient NNS cord-005453-4057qib7 14794 14 . . . cord-005453-4057qib7 14795 1 After after IN cord-005453-4057qib7 14795 2 introducing introduce VBG cord-005453-4057qib7 14795 3 US US NNP cord-005453-4057qib7 14795 4 we -PRON- PRP cord-005453-4057qib7 14795 5 have have VBP cord-005453-4057qib7 14795 6 observed observe VBN cord-005453-4057qib7 14795 7 a a DT cord-005453-4057qib7 14795 8 significant significant JJ cord-005453-4057qib7 14795 9 reduction reduction NN cord-005453-4057qib7 14795 10 of of IN cord-005453-4057qib7 14795 11 the the DT cord-005453-4057qib7 14795 12 number number NN cord-005453-4057qib7 14795 13 of of IN cord-005453-4057qib7 14795 14 CVC CVC NNP cord-005453-4057qib7 14795 15 insertion insertion NN cord-005453-4057qib7 14795 16 required require VBN cord-005453-4057qib7 14795 17 for for IN cord-005453-4057qib7 14795 18 successful successful JJ cord-005453-4057qib7 14795 19 apheresis apheresis NN cord-005453-4057qib7 14795 20 from from IN cord-005453-4057qib7 14795 21 31 31 CD cord-005453-4057qib7 14795 22 % % NN cord-005453-4057qib7 14795 23 to to IN cord-005453-4057qib7 14795 24 9 9 CD cord-005453-4057qib7 14795 25 % % NN cord-005453-4057qib7 14795 26 ( ( -LRB- cord-005453-4057qib7 14795 27 p=0.01 p=0.01 NNP cord-005453-4057qib7 14795 28 ; ; : cord-005453-4057qib7 14795 29 Chi Chi NNP cord-005453-4057qib7 14795 30 - - HYPH cord-005453-4057qib7 14795 31 square square JJ cord-005453-4057qib7 14795 32 test test NN cord-005453-4057qib7 14795 33 with with IN cord-005453-4057qib7 14795 34 Fisher Fisher NNP cord-005453-4057qib7 14795 35 's 's POS cord-005453-4057qib7 14795 36 exact exact NN cord-005453-4057qib7 14795 37 ) ) -RRB- cord-005453-4057qib7 14795 38 . . . cord-005453-4057qib7 14796 1 Thirty thirty CD cord-005453-4057qib7 14796 2 one one CD cord-005453-4057qib7 14796 3 procedures procedure NNS cord-005453-4057qib7 14796 4 were be VBD cord-005453-4057qib7 14796 5 completed complete VBN cord-005453-4057qib7 14796 6 with with IN cord-005453-4057qib7 14796 7 peripheral peripheral JJ cord-005453-4057qib7 14796 8 VA VA NNP cord-005453-4057qib7 14796 9 ( ( -LRB- cord-005453-4057qib7 14796 10 91 91 CD cord-005453-4057qib7 14796 11 % % NN cord-005453-4057qib7 14796 12 ) ) -RRB- cord-005453-4057qib7 14796 13 . . . cord-005453-4057qib7 14797 1 Ultrasound ultrasound NN cord-005453-4057qib7 14797 2 device device NN cord-005453-4057qib7 14797 3 enabled enable VBD cord-005453-4057qib7 14797 4 cannulation cannulation NN cord-005453-4057qib7 14797 5 not not RB cord-005453-4057qib7 14797 6 only only RB cord-005453-4057qib7 14797 7 the the DT cord-005453-4057qib7 14797 8 superficial superficial JJ cord-005453-4057qib7 14797 9 veins vein NNS cord-005453-4057qib7 14797 10 but but CC cord-005453-4057qib7 14797 11 also also RB cord-005453-4057qib7 14797 12 for for IN cord-005453-4057qib7 14797 13 the the DT cord-005453-4057qib7 14797 14 deeper deep JJR cord-005453-4057qib7 14797 15 veins vein NNS cord-005453-4057qib7 14797 16 . . . cord-005453-4057qib7 14798 1 Cannulation cannulation NN cord-005453-4057qib7 14798 2 sites site NNS cord-005453-4057qib7 14798 3 included include VBD cord-005453-4057qib7 14798 4 upper upper JJ cord-005453-4057qib7 14798 5 arm arm NN cord-005453-4057qib7 14798 6 cephalic cephalic JJ cord-005453-4057qib7 14798 7 vein vein NN cord-005453-4057qib7 14798 8 ( ( -LRB- cord-005453-4057qib7 14798 9 39 39 CD cord-005453-4057qib7 14798 10 % % NN cord-005453-4057qib7 14798 11 ) ) -RRB- cord-005453-4057qib7 14798 12 , , , cord-005453-4057qib7 14798 13 median median JJ cord-005453-4057qib7 14798 14 cubital cubital JJ cord-005453-4057qib7 14798 15 vein vein NN cord-005453-4057qib7 14798 16 ( ( -LRB- cord-005453-4057qib7 14798 17 35 35 CD cord-005453-4057qib7 14798 18 % % NN cord-005453-4057qib7 14798 19 ) ) -RRB- cord-005453-4057qib7 14798 20 , , , cord-005453-4057qib7 14798 21 upper upper JJ cord-005453-4057qib7 14798 22 arm arm NN cord-005453-4057qib7 14798 23 basilic basilic JJ cord-005453-4057qib7 14798 24 vein vein NN cord-005453-4057qib7 14798 25 ( ( -LRB- cord-005453-4057qib7 14798 26 13 13 CD cord-005453-4057qib7 14798 27 % % NN cord-005453-4057qib7 14798 28 ) ) -RRB- cord-005453-4057qib7 14798 29 , , , cord-005453-4057qib7 14798 30 median median JJ cord-005453-4057qib7 14798 31 antebrachial antebrachial JJ cord-005453-4057qib7 14798 32 vein vein NN cord-005453-4057qib7 14798 33 ( ( -LRB- cord-005453-4057qib7 14798 34 13 13 CD cord-005453-4057qib7 14798 35 % % NN cord-005453-4057qib7 14798 36 ) ) -RRB- cord-005453-4057qib7 14798 37 . . . cord-005453-4057qib7 14799 1 Out out IN cord-005453-4057qib7 14799 2 of of IN cord-005453-4057qib7 14799 3 the the DT cord-005453-4057qib7 14799 4 34 34 CD cord-005453-4057qib7 14799 5 collections collection NNS cord-005453-4057qib7 14799 6 , , , cord-005453-4057qib7 14799 7 13 13 CD cord-005453-4057qib7 14799 8 were be VBD cord-005453-4057qib7 14799 9 considered consider VBN cord-005453-4057qib7 14799 10 problematic problematic JJ cord-005453-4057qib7 14799 11 ( ( -LRB- cord-005453-4057qib7 14799 12 42 42 CD cord-005453-4057qib7 14799 13 % % NN cord-005453-4057qib7 14799 14 ) ) -RRB- cord-005453-4057qib7 14799 15 . . . cord-005453-4057qib7 14800 1 No no DT cord-005453-4057qib7 14800 2 difference difference NN cord-005453-4057qib7 14800 3 in in IN cord-005453-4057qib7 14800 4 an an DT cord-005453-4057qib7 14800 5 average average JJ cord-005453-4057qib7 14800 6 flow flow NN cord-005453-4057qib7 14800 7 rate rate NN cord-005453-4057qib7 14800 8 was be VBD cord-005453-4057qib7 14800 9 observed observe VBN cord-005453-4057qib7 14800 10 between between IN cord-005453-4057qib7 14800 11 procedures procedure NNS cord-005453-4057qib7 14800 12 performed perform VBN cord-005453-4057qib7 14800 13 peripherally peripherally RB cord-005453-4057qib7 14800 14 with with IN cord-005453-4057qib7 14800 15 and and CC cord-005453-4057qib7 14800 16 without without IN cord-005453-4057qib7 14800 17 ultrasound ultrasound NN cord-005453-4057qib7 14800 18 usage usage NN cord-005453-4057qib7 14800 19 ( ( -LRB- cord-005453-4057qib7 14800 20 p=0.34 p=0.34 NN cord-005453-4057qib7 14800 21 ; ; : cord-005453-4057qib7 14800 22 U U NNP cord-005453-4057qib7 14800 23 Mann Mann NNP cord-005453-4057qib7 14800 24 - - HYPH cord-005453-4057qib7 14800 25 Whitney Whitney NNP cord-005453-4057qib7 14800 26 test test NN cord-005453-4057qib7 14800 27 ) ) -RRB- cord-005453-4057qib7 14800 28 . . . cord-005453-4057qib7 14801 1 Conclusions conclusion NNS cord-005453-4057qib7 14801 2 : : : cord-005453-4057qib7 14802 1 Despite despite IN cord-005453-4057qib7 14802 2 no no DT cord-005453-4057qib7 14802 3 previous previous JJ cord-005453-4057qib7 14802 4 experience experience NN cord-005453-4057qib7 14802 5 in in IN cord-005453-4057qib7 14802 6 US US NNP cord-005453-4057qib7 14802 7 guidance guidance NN cord-005453-4057qib7 14802 8 , , , cord-005453-4057qib7 14802 9 we -PRON- PRP cord-005453-4057qib7 14802 10 have have VBP cord-005453-4057qib7 14802 11 successfully successfully RB cord-005453-4057qib7 14802 12 managed manage VBN cord-005453-4057qib7 14802 13 to to TO cord-005453-4057qib7 14802 14 introduce introduce VB cord-005453-4057qib7 14802 15 the the DT cord-005453-4057qib7 14802 16 new new JJ cord-005453-4057qib7 14802 17 method method NN cord-005453-4057qib7 14802 18 in in IN cord-005453-4057qib7 14802 19 our -PRON- PRP$ cord-005453-4057qib7 14802 20 apheresis apheresis NN cord-005453-4057qib7 14802 21 unit unit NN cord-005453-4057qib7 14802 22 . . . cord-005453-4057qib7 14803 1 Within within IN cord-005453-4057qib7 14803 2 5 5 CD cord-005453-4057qib7 14803 3 months month NNS cord-005453-4057qib7 14803 4 , , , cord-005453-4057qib7 14803 5 we -PRON- PRP cord-005453-4057qib7 14803 6 have have VBP cord-005453-4057qib7 14803 7 reduced reduce VBN cord-005453-4057qib7 14803 8 CVC CVC NNP cord-005453-4057qib7 14803 9 usage usage NN cord-005453-4057qib7 14803 10 threefold threefold NN cord-005453-4057qib7 14803 11 and and CC cord-005453-4057qib7 14803 12 as as IN cord-005453-4057qib7 14803 13 the the DT cord-005453-4057qib7 14803 14 personnel personnel NNS cord-005453-4057qib7 14803 15 is be VBZ cord-005453-4057qib7 14803 16 gaining gain VBG cord-005453-4057qib7 14803 17 more more JJR cord-005453-4057qib7 14803 18 experience experience NN cord-005453-4057qib7 14803 19 , , , cord-005453-4057qib7 14803 20 we -PRON- PRP cord-005453-4057qib7 14803 21 suppose suppose VBP cord-005453-4057qib7 14803 22 that that IN cord-005453-4057qib7 14803 23 the the DT cord-005453-4057qib7 14803 24 CVC CVC NNP cord-005453-4057qib7 14803 25 usage usage NN cord-005453-4057qib7 14803 26 may may MD cord-005453-4057qib7 14803 27 be be VB cord-005453-4057qib7 14803 28 reduced reduce VBN cord-005453-4057qib7 14803 29 to to IN cord-005453-4057qib7 14803 30 episodic episodic JJ cord-005453-4057qib7 14803 31 cases case NNS cord-005453-4057qib7 14803 32 . . . cord-005453-4057qib7 14804 1 Despite despite IN cord-005453-4057qib7 14804 2 slightly slightly RB cord-005453-4057qib7 14804 3 higher high JJR cord-005453-4057qib7 14804 4 number number NN cord-005453-4057qib7 14804 5 of of IN cord-005453-4057qib7 14804 6 pressure pressure NN cord-005453-4057qib7 14804 7 alarms alarm NNS cord-005453-4057qib7 14804 8 , , , cord-005453-4057qib7 14804 9 all all DT cord-005453-4057qib7 14804 10 procedures procedure NNS cord-005453-4057qib7 14804 11 with with IN cord-005453-4057qib7 14804 12 ultrasound ultrasound NN cord-005453-4057qib7 14804 13 guidance guidance NN cord-005453-4057qib7 14804 14 were be VBD cord-005453-4057qib7 14804 15 completed complete VBN cord-005453-4057qib7 14804 16 as as IN cord-005453-4057qib7 14804 17 planned plan VBN cord-005453-4057qib7 14804 18 . . . cord-005453-4057qib7 14805 1 Ultrasound ultrasound NN cord-005453-4057qib7 14805 2 guidance guidance NN cord-005453-4057qib7 14805 3 is be VBZ cord-005453-4057qib7 14805 4 the the DT cord-005453-4057qib7 14805 5 most most RBS cord-005453-4057qib7 14805 6 important important JJ cord-005453-4057qib7 14805 7 tool tool NN cord-005453-4057qib7 14805 8 for for IN cord-005453-4057qib7 14805 9 significant significant JJ cord-005453-4057qib7 14805 10 increase increase NN cord-005453-4057qib7 14805 11 in in IN cord-005453-4057qib7 14805 12 peripheral peripheral JJ cord-005453-4057qib7 14805 13 VA VA NNP cord-005453-4057qib7 14805 14 usage usage NN cord-005453-4057qib7 14805 15 and and CC cord-005453-4057qib7 14805 16 may may MD cord-005453-4057qib7 14805 17 become become VB cord-005453-4057qib7 14805 18 the the DT cord-005453-4057qib7 14805 19 only only JJ cord-005453-4057qib7 14805 20 option option NN cord-005453-4057qib7 14805 21 for for IN cord-005453-4057qib7 14805 22 patients patient NNS cord-005453-4057qib7 14805 23 with with IN cord-005453-4057qib7 14805 24 difficult difficult JJ cord-005453-4057qib7 14805 25 VA VA NNP cord-005453-4057qib7 14805 26 . . . cord-005453-4057qib7 14806 1 Disclosure disclosure NN cord-005453-4057qib7 14806 2 : : : cord-005453-4057qib7 14806 3 Nothing nothing NN cord-005453-4057qib7 14806 4 to to TO cord-005453-4057qib7 14806 5 declare declare VB cord-005453-4057qib7 14806 6 . . . cord-005453-4057qib7 14807 1 Abstract Abstract NNP cord-005453-4057qib7 14807 2 already already RB cord-005453-4057qib7 14807 3 published publish VBN cord-005453-4057qib7 14807 4 . . . cord-005453-4057qib7 14808 1 Donor donor NN cord-005453-4057qib7 14808 2 blood blood NN cord-005453-4057qib7 14808 3 management management NN cord-005453-4057qib7 14808 4 in in IN cord-005453-4057qib7 14808 5 healthy healthy JJ cord-005453-4057qib7 14808 6 bone bone NN cord-005453-4057qib7 14808 7 marrow marrow NN cord-005453-4057qib7 14808 8 donors donor NNS cord-005453-4057qib7 14808 9 : : : cord-005453-4057qib7 14809 1 A a DT cord-005453-4057qib7 14809 2 retrospective retrospective JJ cord-005453-4057qib7 14809 3 single single JJ cord-005453-4057qib7 14809 4 institution institution NN cord-005453-4057qib7 14809 5 analysis analysis NN cord-005453-4057qib7 14809 6 Background Background NNP cord-005453-4057qib7 14809 7 : : : cord-005453-4057qib7 14809 8 Over over IN cord-005453-4057qib7 14809 9 the the DT cord-005453-4057qib7 14809 10 last last JJ cord-005453-4057qib7 14809 11 two two CD cord-005453-4057qib7 14809 12 decades decade NNS cord-005453-4057qib7 14809 13 mobilized mobilize VBD cord-005453-4057qib7 14809 14 peripheral peripheral JJ cord-005453-4057qib7 14809 15 blood blood NN cord-005453-4057qib7 14809 16 stem stem NN cord-005453-4057qib7 14809 17 cells cell NNS cord-005453-4057qib7 14809 18 ( ( -LRB- cord-005453-4057qib7 14809 19 PBSC PBSC NNP cord-005453-4057qib7 14809 20 ) ) -RRB- cord-005453-4057qib7 14809 21 have have VBP cord-005453-4057qib7 14809 22 been be VBN cord-005453-4057qib7 14809 23 established establish VBN cord-005453-4057qib7 14809 24 as as IN cord-005453-4057qib7 14809 25 the the DT cord-005453-4057qib7 14809 26 main main JJ cord-005453-4057qib7 14809 27 source source NN cord-005453-4057qib7 14809 28 of of IN cord-005453-4057qib7 14809 29 stem stem NN cord-005453-4057qib7 14809 30 cells cell NNS cord-005453-4057qib7 14809 31 because because IN cord-005453-4057qib7 14809 32 of of IN cord-005453-4057qib7 14809 33 improved improve VBN cord-005453-4057qib7 14809 34 engraftment engraftment NN cord-005453-4057qib7 14809 35 and and CC cord-005453-4057qib7 14809 36 no no DT cord-005453-4057qib7 14809 37 necessity necessity NN cord-005453-4057qib7 14809 38 for for IN cord-005453-4057qib7 14809 39 hospitalization hospitalization NN cord-005453-4057qib7 14809 40 for for IN cord-005453-4057qib7 14809 41 the the DT cord-005453-4057qib7 14809 42 donors donor NNS cord-005453-4057qib7 14809 43 . . . cord-005453-4057qib7 14810 1 Nevertheless nevertheless RB cord-005453-4057qib7 14810 2 , , , cord-005453-4057qib7 14810 3 due due IN cord-005453-4057qib7 14810 4 to to IN cord-005453-4057qib7 14810 5 the the DT cord-005453-4057qib7 14810 6 introduction introduction NN cord-005453-4057qib7 14810 7 of of IN cord-005453-4057qib7 14810 8 promising promise VBG cord-005453-4057qib7 14810 9 new new JJ cord-005453-4057qib7 14810 10 transplant transplant NN cord-005453-4057qib7 14810 11 regimens regimen NNS cord-005453-4057qib7 14810 12 , , , cord-005453-4057qib7 14810 13 especially especially RB cord-005453-4057qib7 14810 14 in in IN cord-005453-4057qib7 14810 15 the the DT cord-005453-4057qib7 14810 16 haploidentical haploidentical JJ cord-005453-4057qib7 14810 17 transplantation transplantation NN cord-005453-4057qib7 14810 18 setting set VBG cord-005453-4057qib7 14810 19 bone bone NN cord-005453-4057qib7 14810 20 marrow marrow NN cord-005453-4057qib7 14810 21 ( ( -LRB- cord-005453-4057qib7 14810 22 BM BM NNP cord-005453-4057qib7 14810 23 ) ) -RRB- cord-005453-4057qib7 14810 24 donations donation NNS cord-005453-4057qib7 14810 25 are be VBP cord-005453-4057qib7 14810 26 regaining regain VBG cord-005453-4057qib7 14810 27 importance importance NN cord-005453-4057qib7 14810 28 . . . cord-005453-4057qib7 14811 1 Although although IN cord-005453-4057qib7 14811 2 for for IN cord-005453-4057qib7 14811 3 both both DT cord-005453-4057qib7 14811 4 donation donation NN cord-005453-4057qib7 14811 5 methods method NNS cord-005453-4057qib7 14811 6 severe severe JJ cord-005453-4057qib7 14811 7 side side NN cord-005453-4057qib7 14811 8 effects effect NNS cord-005453-4057qib7 14811 9 are be VBP cord-005453-4057qib7 14811 10 rarely rarely RB cord-005453-4057qib7 14811 11 described describe VBN cord-005453-4057qib7 14811 12 , , , cord-005453-4057qib7 14811 13 BM BM NNP cord-005453-4057qib7 14811 14 collection collection NN cord-005453-4057qib7 14811 15 is be VBZ cord-005453-4057qib7 14811 16 associated associate VBN cord-005453-4057qib7 14811 17 with with IN cord-005453-4057qib7 14811 18 considerable considerable JJ cord-005453-4057qib7 14811 19 blood blood NN cord-005453-4057qib7 14811 20 loss loss NN cord-005453-4057qib7 14811 21 and and CC cord-005453-4057qib7 14811 22 hence hence RB cord-005453-4057qib7 14811 23 symptoms symptom NNS cord-005453-4057qib7 14811 24 of of IN cord-005453-4057qib7 14811 25 acute acute JJ cord-005453-4057qib7 14811 26 blood blood NN cord-005453-4057qib7 14811 27 loss loss NN cord-005453-4057qib7 14811 28 are be VBP cord-005453-4057qib7 14811 29 commonly commonly RB cord-005453-4057qib7 14811 30 observed observe VBN cord-005453-4057qib7 14811 31 . . . cord-005453-4057qib7 14812 1 Therefore therefore RB cord-005453-4057qib7 14812 2 autologous autologous JJ cord-005453-4057qib7 14812 3 blood blood NN cord-005453-4057qib7 14812 4 are be VBP cord-005453-4057qib7 14812 5 collected collect VBN cord-005453-4057qib7 14812 6 routinely routinely RB cord-005453-4057qib7 14812 7 in in IN cord-005453-4057qib7 14812 8 some some DT cord-005453-4057qib7 14812 9 institutions institution NNS cord-005453-4057qib7 14812 10 before before IN cord-005453-4057qib7 14812 11 donation donation NN cord-005453-4057qib7 14812 12 . . . cord-005453-4057qib7 14813 1 Since since IN cord-005453-4057qib7 14813 2 the the DT cord-005453-4057qib7 14813 3 collected collect VBN cord-005453-4057qib7 14813 4 bone bone NN cord-005453-4057qib7 14813 5 marrow marrow NN cord-005453-4057qib7 14813 6 amount amount NN cord-005453-4057qib7 14813 7 depends depend VBZ cord-005453-4057qib7 14813 8 on on IN cord-005453-4057qib7 14813 9 the the DT cord-005453-4057qib7 14813 10 target target NN cord-005453-4057qib7 14813 11 dose dose NN cord-005453-4057qib7 14813 12 , , , cord-005453-4057qib7 14813 13 the the DT cord-005453-4057qib7 14813 14 WBC WBC NNP cord-005453-4057qib7 14813 15 yield yield NN cord-005453-4057qib7 14813 16 in in IN cord-005453-4057qib7 14813 17 the the DT cord-005453-4057qib7 14813 18 product product NN cord-005453-4057qib7 14813 19 influences influence VBZ cord-005453-4057qib7 14813 20 the the DT cord-005453-4057qib7 14813 21 required require VBN cord-005453-4057qib7 14813 22 bone bone NN cord-005453-4057qib7 14813 23 marrow marrow NN cord-005453-4057qib7 14813 24 volume volume NN cord-005453-4057qib7 14813 25 . . . cord-005453-4057qib7 14814 1 Therefore therefore RB cord-005453-4057qib7 14814 2 we -PRON- PRP cord-005453-4057qib7 14814 3 sought seek VBD cord-005453-4057qib7 14814 4 to to TO cord-005453-4057qib7 14814 5 investigate investigate VB cord-005453-4057qib7 14814 6 the the DT cord-005453-4057qib7 14814 7 relationship relationship NN cord-005453-4057qib7 14814 8 between between IN cord-005453-4057qib7 14814 9 collection collection NN cord-005453-4057qib7 14814 10 volume volume NN cord-005453-4057qib7 14814 11 , , , cord-005453-4057qib7 14814 12 RBC RBC NNP cord-005453-4057qib7 14814 13 volume volume NN cord-005453-4057qib7 14814 14 removal removal NN cord-005453-4057qib7 14814 15 , , , cord-005453-4057qib7 14814 16 drop drop NN cord-005453-4057qib7 14814 17 in in IN cord-005453-4057qib7 14814 18 Hb Hb NNP cord-005453-4057qib7 14814 19 and and CC cord-005453-4057qib7 14814 20 indications indication NNS cord-005453-4057qib7 14814 21 for for IN cord-005453-4057qib7 14814 22 blood blood NN cord-005453-4057qib7 14814 23 transfusion transfusion NN cord-005453-4057qib7 14814 24 . . . cord-005453-4057qib7 14815 1 Furthermore furthermore RB cord-005453-4057qib7 14815 2 , , , cord-005453-4057qib7 14815 3 we -PRON- PRP cord-005453-4057qib7 14815 4 assessed assess VBD cord-005453-4057qib7 14815 5 WBC WBC NNP cord-005453-4057qib7 14815 6 and and CC cord-005453-4057qib7 14815 7 CD34+yields CD34+yields NNPS cord-005453-4057qib7 14815 8 in in IN cord-005453-4057qib7 14815 9 relationship relationship NN cord-005453-4057qib7 14815 10 to to IN cord-005453-4057qib7 14815 11 various various JJ cord-005453-4057qib7 14815 12 donor donor NN cord-005453-4057qib7 14815 13 parameters parameter NNS cord-005453-4057qib7 14815 14 and and CC cord-005453-4057qib7 14815 15 to to TO cord-005453-4057qib7 14815 16 product product NN cord-005453-4057qib7 14815 17 volume volume NN cord-005453-4057qib7 14815 18 , , , cord-005453-4057qib7 14815 19 in in IN cord-005453-4057qib7 14815 20 order order NN cord-005453-4057qib7 14815 21 to to TO cord-005453-4057qib7 14815 22 find find VB cord-005453-4057qib7 14815 23 prediction prediction NN cord-005453-4057qib7 14815 24 tools tool NNS cord-005453-4057qib7 14815 25 for for IN cord-005453-4057qib7 14815 26 collection collection NN cord-005453-4057qib7 14815 27 volumes volume NNS cord-005453-4057qib7 14815 28 . . . cord-005453-4057qib7 14816 1 Methods method NNS cord-005453-4057qib7 14816 2 : : : cord-005453-4057qib7 14816 3 489 489 CD cord-005453-4057qib7 14816 4 allogeneic allogeneic NN cord-005453-4057qib7 14816 5 bone bone NN cord-005453-4057qib7 14816 6 marrow marrow NN cord-005453-4057qib7 14816 7 harvests harvest NNS cord-005453-4057qib7 14816 8 from from IN cord-005453-4057qib7 14816 9 adult adult NN cord-005453-4057qib7 14816 10 donors donor NNS cord-005453-4057qib7 14816 11 were be VBD cord-005453-4057qib7 14816 12 performed perform VBN cord-005453-4057qib7 14816 13 at at IN cord-005453-4057qib7 14816 14 our -PRON- PRP$ cord-005453-4057qib7 14816 15 institution institution NN cord-005453-4057qib7 14816 16 and and CC cord-005453-4057qib7 14816 17 retrospectively retrospectively RB cord-005453-4057qib7 14816 18 analyzed analyze VBN cord-005453-4057qib7 14816 19 . . . cord-005453-4057qib7 14817 1 Complete complete JJ cord-005453-4057qib7 14817 2 blood blood NN cord-005453-4057qib7 14817 3 counts count NNS cord-005453-4057qib7 14817 4 , , , cord-005453-4057qib7 14817 5 serum serum NN cord-005453-4057qib7 14817 6 iron iron NN cord-005453-4057qib7 14817 7 and and CC cord-005453-4057qib7 14817 8 ferritin ferritin NN cord-005453-4057qib7 14817 9 were be VBD cord-005453-4057qib7 14817 10 assessed assess VBN cord-005453-4057qib7 14817 11 at at IN cord-005453-4057qib7 14817 12 work work NN cord-005453-4057qib7 14817 13 - - HYPH cord-005453-4057qib7 14817 14 up up NN cord-005453-4057qib7 14817 15 and and CC cord-005453-4057qib7 14817 16 4 4 CD cord-005453-4057qib7 14817 17 weeks week NNS cord-005453-4057qib7 14817 18 after after IN cord-005453-4057qib7 14817 19 donation donation NN cord-005453-4057qib7 14817 20 . . . cord-005453-4057qib7 14818 1 The the DT cord-005453-4057qib7 14818 2 bone bone NN cord-005453-4057qib7 14818 3 marrow marrow NN cord-005453-4057qib7 14818 4 product product NN cord-005453-4057qib7 14818 5 quality quality NN cord-005453-4057qib7 14818 6 including include VBG cord-005453-4057qib7 14818 7 WBC WBC NNP cord-005453-4057qib7 14818 8 , , , cord-005453-4057qib7 14818 9 hematocrit hematocrit NN cord-005453-4057qib7 14818 10 ( ( -LRB- cord-005453-4057qib7 14818 11 Hct Hct NNP cord-005453-4057qib7 14818 12 ) ) -RRB- cord-005453-4057qib7 14818 13 and and CC cord-005453-4057qib7 14818 14 CD34 CD34 NNP cord-005453-4057qib7 14818 15 + + CC cord-005453-4057qib7 14818 16 cells cell NNS cord-005453-4057qib7 14818 17 were be VBD cord-005453-4057qib7 14818 18 assessed assess VBN cord-005453-4057qib7 14818 19 by by IN cord-005453-4057qib7 14818 20 automatic automatic JJ cord-005453-4057qib7 14818 21 hemocytometry hemocytometry NNP cord-005453-4057qib7 14818 22 and and CC cord-005453-4057qib7 14818 23 single single JJ cord-005453-4057qib7 14818 24 - - HYPH cord-005453-4057qib7 14818 25 platform platform NN cord-005453-4057qib7 14818 26 flow flow NN cord-005453-4057qib7 14818 27 cytometry cytometry NN cord-005453-4057qib7 14818 28 with with IN cord-005453-4057qib7 14818 29 ISHAGE ISHAGE NNP cord-005453-4057qib7 14818 30 gating gate VBG cord-005453-4057qib7 14818 31 . . . cord-005453-4057qib7 14819 1 Results result NNS cord-005453-4057qib7 14819 2 : : : cord-005453-4057qib7 14820 1 Besides besides IN cord-005453-4057qib7 14820 2 local local JJ cord-005453-4057qib7 14820 3 pain pain NN cord-005453-4057qib7 14820 4 most most JJS cord-005453-4057qib7 14820 5 of of IN cord-005453-4057qib7 14820 6 the the DT cord-005453-4057qib7 14820 7 side side NN cord-005453-4057qib7 14820 8 effects effect NNS cord-005453-4057qib7 14820 9 were be VBD cord-005453-4057qib7 14820 10 related relate VBN cord-005453-4057qib7 14820 11 to to IN cord-005453-4057qib7 14820 12 blood blood NN cord-005453-4057qib7 14820 13 loss loss NN cord-005453-4057qib7 14820 14 . . . cord-005453-4057qib7 14821 1 None none NN cord-005453-4057qib7 14821 2 of of IN cord-005453-4057qib7 14821 3 the the DT cord-005453-4057qib7 14821 4 donors donor NNS cord-005453-4057qib7 14821 5 received receive VBD cord-005453-4057qib7 14821 6 blood blood NN cord-005453-4057qib7 14821 7 transfusions transfusion NNS cord-005453-4057qib7 14821 8 . . . cord-005453-4057qib7 14822 1 The the DT cord-005453-4057qib7 14822 2 mean mean JJ cord-005453-4057qib7 14822 3 reduction reduction NN cord-005453-4057qib7 14822 4 of of IN cord-005453-4057qib7 14822 5 hemoglobin hemoglobin NN cord-005453-4057qib7 14822 6 levels level NNS cord-005453-4057qib7 14822 7 was be VBD cord-005453-4057qib7 14822 8 2.5 2.5 CD cord-005453-4057qib7 14822 9 g g NN cord-005453-4057qib7 14822 10 / / SYM cord-005453-4057qib7 14822 11 dl dl NN cord-005453-4057qib7 14822 12 with with IN cord-005453-4057qib7 14822 13 a a DT cord-005453-4057qib7 14822 14 minimum minimum JJ cord-005453-4057qib7 14822 15 hemoglobin hemoglobin NN cord-005453-4057qib7 14822 16 level level NN cord-005453-4057qib7 14822 17 of of IN cord-005453-4057qib7 14822 18 8.9g 8.9g CD cord-005453-4057qib7 14822 19 / / SYM cord-005453-4057qib7 14822 20 dl dl NN cord-005453-4057qib7 14822 21 and and CC cord-005453-4057qib7 14822 22 a a DT cord-005453-4057qib7 14822 23 persistent persistent JJ cord-005453-4057qib7 14822 24 anemia anemia NN cord-005453-4057qib7 14822 25 according accord VBG cord-005453-4057qib7 14822 26 to to IN cord-005453-4057qib7 14822 27 WHO WHO NNP cord-005453-4057qib7 14822 28 criteria criterion NNS cord-005453-4057qib7 14822 29 after after IN cord-005453-4057qib7 14822 30 4 4 CD cord-005453-4057qib7 14822 31 weeks week NNS cord-005453-4057qib7 14822 32 in in IN cord-005453-4057qib7 14822 33 7.9 7.9 CD cord-005453-4057qib7 14822 34 % % NN cord-005453-4057qib7 14822 35 and and CC cord-005453-4057qib7 14822 36 pathologically pathologically RB cord-005453-4057qib7 14822 37 low low JJ cord-005453-4057qib7 14822 38 ferritin ferritin NN cord-005453-4057qib7 14822 39 levels level NNS cord-005453-4057qib7 14822 40 in in IN cord-005453-4057qib7 14822 41 29 29 CD cord-005453-4057qib7 14822 42 % % NN cord-005453-4057qib7 14822 43 . . . cord-005453-4057qib7 14823 1 No no DT cord-005453-4057qib7 14823 2 donor donor NN cord-005453-4057qib7 14823 3 presented present VBD cord-005453-4057qib7 14823 4 symptoms symptom NNS cord-005453-4057qib7 14823 5 with with IN cord-005453-4057qib7 14823 6 indication indication NN cord-005453-4057qib7 14823 7 for for IN cord-005453-4057qib7 14823 8 blood blood NN cord-005453-4057qib7 14823 9 transfusion transfusion NN cord-005453-4057qib7 14823 10 . . . cord-005453-4057qib7 14824 1 The the DT cord-005453-4057qib7 14824 2 median median JJ cord-005453-4057qib7 14824 3 WBC WBC NNP cord-005453-4057qib7 14824 4 concentration concentration NN cord-005453-4057qib7 14824 5 of of IN cord-005453-4057qib7 14824 6 the the DT cord-005453-4057qib7 14824 7 BM BM NNP cord-005453-4057qib7 14824 8 product product NN cord-005453-4057qib7 14824 9 was be VBD cord-005453-4057qib7 14824 10 26.5 26.5 CD cord-005453-4057qib7 14824 11 / / SYM cord-005453-4057qib7 14824 12 nl nl NNP cord-005453-4057qib7 14824 13 ( ( -LRB- cord-005453-4057qib7 14824 14 5 5 CD cord-005453-4057qib7 14824 15 - - SYM cord-005453-4057qib7 14824 16 95 95 CD cord-005453-4057qib7 14824 17 % % NN cord-005453-4057qib7 14825 1 percentile:16.77 percentile:16.77 NNP cord-005453-4057qib7 14825 2 - - HYPH cord-005453-4057qib7 14825 3 38.75/ 38.75/ NNP cord-005453-4057qib7 14825 4 nl nl NN cord-005453-4057qib7 14825 5 ) ) -RRB- cord-005453-4057qib7 14826 1 the the DT cord-005453-4057qib7 14826 2 CD34+cell CD34+cell NNP cord-005453-4057qib7 14826 3 concentration concentration NN cord-005453-4057qib7 14827 1 186.5 186.5 CD cord-005453-4057qib7 14827 2 / / SYM cord-005453-4057qib7 14827 3 μl μl XX cord-005453-4057qib7 14828 1 ( ( -LRB- cord-005453-4057qib7 14828 2 5 5 CD cord-005453-4057qib7 14828 3 - - SYM cord-005453-4057qib7 14828 4 95 95 CD cord-005453-4057qib7 14828 5 % % NN cord-005453-4057qib7 14828 6 percentile percentile NN cord-005453-4057qib7 14828 7 : : : cord-005453-4057qib7 14828 8 73.92 73.92 CD cord-005453-4057qib7 14828 9 - - HYPH cord-005453-4057qib7 14828 10 346.9 346.9 CD cord-005453-4057qib7 14828 11 / / SYM cord-005453-4057qib7 14828 12 μl μl NN cord-005453-4057qib7 14828 13 ) ) -RRB- cord-005453-4057qib7 14828 14 . . . cord-005453-4057qib7 14829 1 In in IN cord-005453-4057qib7 14829 2 the the DT cord-005453-4057qib7 14829 3 linear linear JJ cord-005453-4057qib7 14829 4 regression regression NN cord-005453-4057qib7 14829 5 analysis analysis NN cord-005453-4057qib7 14829 6 leukocyte leukocyte NN cord-005453-4057qib7 14829 7 counts count VBZ cord-005453-4057qib7 14829 8 of of IN cord-005453-4057qib7 14829 9 the the DT cord-005453-4057qib7 14829 10 donor donor NN cord-005453-4057qib7 14829 11 before before IN cord-005453-4057qib7 14829 12 donation donation NN cord-005453-4057qib7 14829 13 correlated correlate VBD cord-005453-4057qib7 14829 14 significantly significantly RB cord-005453-4057qib7 14829 15 with with IN cord-005453-4057qib7 14829 16 WBC WBC NNP cord-005453-4057qib7 14829 17 concentration concentration NN cord-005453-4057qib7 14829 18 in in IN cord-005453-4057qib7 14829 19 the the DT cord-005453-4057qib7 14829 20 product product NN cord-005453-4057qib7 14829 21 . . . cord-005453-4057qib7 14830 1 Thus thus RB cord-005453-4057qib7 14830 2 in in IN cord-005453-4057qib7 14830 3 order order NN cord-005453-4057qib7 14830 4 to to TO cord-005453-4057qib7 14830 5 collect collect VB cord-005453-4057qib7 14830 6 with with IN cord-005453-4057qib7 14830 7 90 90 CD cord-005453-4057qib7 14830 8 % % NN cord-005453-4057qib7 14830 9 certainty certainty NN cord-005453-4057qib7 14830 10 the the DT cord-005453-4057qib7 14830 11 300 300 CD cord-005453-4057qib7 14830 12 Mio Mio NNP cord-005453-4057qib7 14830 13 WBC WBC NNP cord-005453-4057qib7 14830 14 which which WDT cord-005453-4057qib7 14830 15 are be VBP cord-005453-4057qib7 14830 16 a a DT cord-005453-4057qib7 14830 17 typical typical JJ cord-005453-4057qib7 14830 18 per per NN cord-005453-4057qib7 14830 19 - - HYPH cord-005453-4057qib7 14830 20 kg kg NN cord-005453-4057qib7 14830 21 dose dose NN cord-005453-4057qib7 14830 22 for for IN cord-005453-4057qib7 14830 23 an an DT cord-005453-4057qib7 14830 24 allogeneic allogeneic NN cord-005453-4057qib7 14830 25 recipient recipient NN cord-005453-4057qib7 14830 26 , , , cord-005453-4057qib7 14830 27 16.24 16.24 CD cord-005453-4057qib7 14830 28 ml ml NNS cord-005453-4057qib7 14830 29 of of IN cord-005453-4057qib7 14830 30 bone bone NN cord-005453-4057qib7 14830 31 marrow marrow NN cord-005453-4057qib7 14830 32 must must MD cord-005453-4057qib7 14830 33 be be VB cord-005453-4057qib7 14830 34 collected collect VBN cord-005453-4057qib7 14830 35 . . . cord-005453-4057qib7 14831 1 Collection collection NN cord-005453-4057qib7 14831 2 volume volume NN cord-005453-4057qib7 14831 3 did do VBD cord-005453-4057qib7 14831 4 not not RB cord-005453-4057qib7 14831 5 systematically systematically RB cord-005453-4057qib7 14831 6 affect affect VB cord-005453-4057qib7 14831 7 WBC WBC NNP cord-005453-4057qib7 14831 8 or or CC cord-005453-4057qib7 14831 9 CD34 CD34 NNP cord-005453-4057qib7 14831 10 + + CC cord-005453-4057qib7 14831 11 cell cell NN cord-005453-4057qib7 14831 12 concentration concentration NN cord-005453-4057qib7 14831 13 . . . cord-005453-4057qib7 14832 1 Conclusions conclusion NNS cord-005453-4057qib7 14832 2 : : : cord-005453-4057qib7 14833 1 Achieving achieve VBG cord-005453-4057qib7 14833 2 high high JJ cord-005453-4057qib7 14833 3 WBC WBC NNP cord-005453-4057qib7 14833 4 yields yield NNS cord-005453-4057qib7 14833 5 in in IN cord-005453-4057qib7 14833 6 the the DT cord-005453-4057qib7 14833 7 bone bone NN cord-005453-4057qib7 14833 8 marrow marrow NN cord-005453-4057qib7 14833 9 product product NN cord-005453-4057qib7 14833 10 allowed allow VBN cord-005453-4057qib7 14833 11 for for IN cord-005453-4057qib7 14833 12 collection collection NN cord-005453-4057qib7 14833 13 of of IN cord-005453-4057qib7 14833 14 relatively relatively RB cord-005453-4057qib7 14833 15 modest modest JJ cord-005453-4057qib7 14833 16 BM BM NNP cord-005453-4057qib7 14833 17 volumes volume NNS cord-005453-4057qib7 14833 18 , , , cord-005453-4057qib7 14833 19 thus thus RB cord-005453-4057qib7 14833 20 protecting protect VBG cord-005453-4057qib7 14833 21 donors donor NNS cord-005453-4057qib7 14833 22 from from IN cord-005453-4057qib7 14833 23 excessive excessive JJ cord-005453-4057qib7 14833 24 blood blood NN cord-005453-4057qib7 14833 25 loss loss NN cord-005453-4057qib7 14833 26 . . . cord-005453-4057qib7 14834 1 Acute acute JJ cord-005453-4057qib7 14834 2 adverse adverse JJ cord-005453-4057qib7 14834 3 events event NNS cord-005453-4057qib7 14834 4 were be VBD cord-005453-4057qib7 14834 5 acceptable acceptable JJ cord-005453-4057qib7 14834 6 . . . cord-005453-4057qib7 14835 1 Optimization optimization NN cord-005453-4057qib7 14835 2 of of IN cord-005453-4057qib7 14835 3 perioperative perioperative JJ cord-005453-4057qib7 14835 4 management management NN cord-005453-4057qib7 14835 5 in in IN cord-005453-4057qib7 14835 6 healthy healthy JJ cord-005453-4057qib7 14835 7 bone bone NN cord-005453-4057qib7 14835 8 marrow marrow NN cord-005453-4057qib7 14835 9 donors donor NNS cord-005453-4057qib7 14835 10 may may MD cord-005453-4057qib7 14835 11 be be VB cord-005453-4057qib7 14835 12 achieved achieve VBN cord-005453-4057qib7 14835 13 by by IN cord-005453-4057qib7 14835 14 good good JJ cord-005453-4057qib7 14835 15 collection collection NN cord-005453-4057qib7 14835 16 technique technique NN cord-005453-4057qib7 14835 17 and and CC cord-005453-4057qib7 14835 18 reevaluation reevaluation NN cord-005453-4057qib7 14835 19 of of IN cord-005453-4057qib7 14835 20 WBC WBC NNP cord-005453-4057qib7 14835 21 yields yield NNS cord-005453-4057qib7 14835 22 of of IN cord-005453-4057qib7 14835 23 each each DT cord-005453-4057qib7 14835 24 institution institution NN cord-005453-4057qib7 14835 25 to to TO cord-005453-4057qib7 14835 26 calculate calculate VB cord-005453-4057qib7 14835 27 required require VBN cord-005453-4057qib7 14835 28 bone bone NN cord-005453-4057qib7 14835 29 marrow marrow NN cord-005453-4057qib7 14835 30 amount amount NN cord-005453-4057qib7 14835 31 . . . cord-005453-4057qib7 14836 1 The the DT cord-005453-4057qib7 14836 2 collection collection NN cord-005453-4057qib7 14836 3 of of IN cord-005453-4057qib7 14836 4 autologous autologous JJ cord-005453-4057qib7 14836 5 blood blood NN cord-005453-4057qib7 14836 6 is be VBZ cord-005453-4057qib7 14836 7 not not RB cord-005453-4057qib7 14836 8 indicated indicate VBN cord-005453-4057qib7 14836 9 . . . cord-005453-4057qib7 14837 1 Furthermore furthermore RB cord-005453-4057qib7 14837 2 stringent stringent JJ cord-005453-4057qib7 14837 3 pre pre JJ cord-005453-4057qib7 14837 4 - - JJ cord-005453-4057qib7 14837 5 and and CC cord-005453-4057qib7 14837 6 postoperative postoperative JJ cord-005453-4057qib7 14837 7 hemoglobin hemoglobin NN cord-005453-4057qib7 14837 8 management management NN cord-005453-4057qib7 14837 9 is be VBZ cord-005453-4057qib7 14837 10 predicted predict VBN cord-005453-4057qib7 14837 11 to to TO cord-005453-4057qib7 14837 12 limit limit VB cord-005453-4057qib7 14837 13 adverse adverse JJ cord-005453-4057qib7 14837 14 effects effect NNS cord-005453-4057qib7 14837 15 . . . cord-005453-4057qib7 14838 1 Disclosure disclosure NN cord-005453-4057qib7 14838 2 : : : cord-005453-4057qib7 14838 3 Nothing nothing NN cord-005453-4057qib7 14838 4 to to TO cord-005453-4057qib7 14838 5 declare declare VB cord-005453-4057qib7 14838 6 . . . cord-005453-4057qib7 14839 1 Donor donor NN cord-005453-4057qib7 14839 2 - - HYPH cord-005453-4057qib7 14839 3 recipient recipient NN cord-005453-4057qib7 14839 4 weight weight NN cord-005453-4057qib7 14839 5 ratio ratio NN cord-005453-4057qib7 14839 6 predicts predict VBZ cord-005453-4057qib7 14839 7 successful successful JJ cord-005453-4057qib7 14839 8 stem stem NN cord-005453-4057qib7 14839 9 cell cell NN cord-005453-4057qib7 14839 10 mobilization mobilization NN cord-005453-4057qib7 14839 11 on on IN cord-005453-4057qib7 14839 12 day day NN cord-005453-4057qib7 14839 13 four four CD cord-005453-4057qib7 14839 14 of of IN cord-005453-4057qib7 14839 15 GCSF GCSF NNP cord-005453-4057qib7 14839 16 mobilization mobilization NN cord-005453-4057qib7 14839 17 Results result NNS cord-005453-4057qib7 14839 18 : : : cord-005453-4057qib7 14839 19 In in IN cord-005453-4057qib7 14839 20 Group Group NNP cord-005453-4057qib7 14839 21 1 1 CD cord-005453-4057qib7 14839 22 median median NN cord-005453-4057qib7 14839 23 age age NN cord-005453-4057qib7 14839 24 of of IN cord-005453-4057qib7 14839 25 donor donor NN cord-005453-4057qib7 14839 26 was be VBD cord-005453-4057qib7 14839 27 41 41 CD cord-005453-4057qib7 14839 28 years year NNS cord-005453-4057qib7 14840 1 ( ( -LRB- cord-005453-4057qib7 14840 2 range range VB cord-005453-4057qib7 14840 3 19 19 CD cord-005453-4057qib7 14840 4 to to TO cord-005453-4057qib7 14840 5 51 51 CD cord-005453-4057qib7 14840 6 years year NNS cord-005453-4057qib7 14840 7 ) ) -RRB- cord-005453-4057qib7 14840 8 . . . cord-005453-4057qib7 14841 1 In in IN cord-005453-4057qib7 14841 2 Group group NN cord-005453-4057qib7 14841 3 2 2 CD cord-005453-4057qib7 14841 4 median median NN cord-005453-4057qib7 14841 5 age age NN cord-005453-4057qib7 14841 6 of of IN cord-005453-4057qib7 14841 7 donor donor NN cord-005453-4057qib7 14841 8 was be VBD cord-005453-4057qib7 14841 9 31years 31years CD cord-005453-4057qib7 14841 10 ( ( -LRB- cord-005453-4057qib7 14841 11 range21 range21 NN cord-005453-4057qib7 14841 12 to to IN cord-005453-4057qib7 14841 13 48 48 CD cord-005453-4057qib7 14841 14 years year NNS cord-005453-4057qib7 14841 15 ) ) -RRB- cord-005453-4057qib7 14841 16 . . . cord-005453-4057qib7 14842 1 Table table NN cord-005453-4057qib7 14842 2 ] ] -RRB- cord-005453-4057qib7 14842 3 1 1 CD cord-005453-4057qib7 14842 4 . . . cord-005453-4057qib7 14843 1 Table table NN cord-005453-4057qib7 14843 2 1 1 CD cord-005453-4057qib7 14843 3 ] ] -RRB- cord-005453-4057qib7 14843 4 elaborates elaborate VBZ cord-005453-4057qib7 14843 5 other other JJ cord-005453-4057qib7 14843 6 parameters parameter NNS cord-005453-4057qib7 14843 7 analyzed analyze VBN cord-005453-4057qib7 14843 8 between between IN cord-005453-4057qib7 14843 9 the the DT cord-005453-4057qib7 14843 10 two two CD cord-005453-4057qib7 14843 11 groups group NNS cord-005453-4057qib7 14843 12 . . . cord-005453-4057qib7 14844 1 One one CD cord-005453-4057qib7 14844 2 patient patient NN cord-005453-4057qib7 14844 3 in in IN cord-005453-4057qib7 14844 4 Group Group NNP cord-005453-4057qib7 14844 5 1 1 CD cord-005453-4057qib7 14844 6 developed develop VBD cord-005453-4057qib7 14844 7 grade grade NN cord-005453-4057qib7 14844 8 II II NNP cord-005453-4057qib7 14844 9 acute acute JJ cord-005453-4057qib7 14844 10 GVHD GVHD NNP cord-005453-4057qib7 14844 11 whereas whereas IN cord-005453-4057qib7 14844 12 3 3 CD cord-005453-4057qib7 14844 13 patients patient NNS cord-005453-4057qib7 14844 14 in in IN cord-005453-4057qib7 14844 15 Group Group NNP cord-005453-4057qib7 14844 16 2 2 CD cord-005453-4057qib7 14844 17 developed develop VBD cord-005453-4057qib7 14844 18 acute acute JJ cord-005453-4057qib7 14844 19 GVHD GVHD NNP cord-005453-4057qib7 14844 20 grade grade NN cord-005453-4057qib7 14844 21 II II NNP cord-005453-4057qib7 14844 22 - - HYPH cord-005453-4057qib7 14844 23 IV IV NNP cord-005453-4057qib7 14844 24 . . . cord-005453-4057qib7 14845 1 At at IN cord-005453-4057qib7 14845 2 the the DT cord-005453-4057qib7 14845 3 last last JJ cord-005453-4057qib7 14845 4 follow follow NN cord-005453-4057qib7 14845 5 up up RP cord-005453-4057qib7 14845 6 no no DT cord-005453-4057qib7 14845 7 ( ( -LRB- cord-005453-4057qib7 14845 8 0/9 0/9 CD cord-005453-4057qib7 14845 9 ) ) -RRB- cord-005453-4057qib7 14845 10 patient patient NN cord-005453-4057qib7 14845 11 in in IN cord-005453-4057qib7 14845 12 Group Group NNP cord-005453-4057qib7 14845 13 1 1 CD cord-005453-4057qib7 14845 14 has have VBZ cord-005453-4057qib7 14845 15 any any DT cord-005453-4057qib7 14845 16 symptoms symptom NNS cord-005453-4057qib7 14845 17 of of IN cord-005453-4057qib7 14845 18 chronic chronic JJ cord-005453-4057qib7 14845 19 GVHD GVHD NNP cord-005453-4057qib7 14845 20 whereas whereas IN cord-005453-4057qib7 14845 21 ( ( -LRB- cord-005453-4057qib7 14845 22 2/5 2/5 CD cord-005453-4057qib7 14845 23 ) ) -RRB- cord-005453-4057qib7 14845 24 patients patient NNS cord-005453-4057qib7 14845 25 in in IN cord-005453-4057qib7 14845 26 Group Group NNP cord-005453-4057qib7 14845 27 2 2 CD cord-005453-4057qib7 14845 28 have have VBP cord-005453-4057qib7 14845 29 features feature NNS cord-005453-4057qib7 14845 30 of of IN cord-005453-4057qib7 14845 31 chronic chronic JJ cord-005453-4057qib7 14845 32 GVHD GVHD NNP cord-005453-4057qib7 14845 33 ( ( -LRB- cord-005453-4057qib7 14846 1 one one CD cord-005453-4057qib7 14846 2 extensive extensive JJ cord-005453-4057qib7 14846 3 , , , cord-005453-4057qib7 14846 4 one one CD cord-005453-4057qib7 14846 5 limited limited JJ cord-005453-4057qib7 14846 6 ) ) -RRB- cord-005453-4057qib7 14846 7 . . . cord-005453-4057qib7 14847 1 Conclusions conclusion NNS cord-005453-4057qib7 14847 2 : : : cord-005453-4057qib7 14848 1 Our -PRON- PRP$ cord-005453-4057qib7 14848 2 observation observation NN cord-005453-4057qib7 14848 3 suggests suggest VBZ cord-005453-4057qib7 14848 4 that that IN cord-005453-4057qib7 14848 5 upfront upfront JJ cord-005453-4057qib7 14848 6 use use NN cord-005453-4057qib7 14848 7 of of IN cord-005453-4057qib7 14848 8 plerixafor plerixafor NN cord-005453-4057qib7 14848 9 in in IN cord-005453-4057qib7 14848 10 combination combination NN cord-005453-4057qib7 14848 11 with with IN cord-005453-4057qib7 14848 12 GCSF GCSF NNP cord-005453-4057qib7 14848 13 modifies modify VBZ cord-005453-4057qib7 14848 14 the the DT cord-005453-4057qib7 14848 15 graft graft NN cord-005453-4057qib7 14848 16 favorably favorably RB cord-005453-4057qib7 14848 17 decreasing decrease VBG cord-005453-4057qib7 14848 18 the the DT cord-005453-4057qib7 14848 19 risk risk NN cord-005453-4057qib7 14848 20 of of IN cord-005453-4057qib7 14848 21 graft graft NN cord-005453-4057qib7 14848 22 failure failure NN cord-005453-4057qib7 14848 23 and and CC cord-005453-4057qib7 14848 24 graft graft NN cord-005453-4057qib7 14848 25 versus versus IN cord-005453-4057qib7 14848 26 host host NN cord-005453-4057qib7 14848 27 disease disease NN cord-005453-4057qib7 14848 28 both both CC cord-005453-4057qib7 14848 29 acute acute JJ cord-005453-4057qib7 14848 30 and and CC cord-005453-4057qib7 14848 31 chronic chronic JJ cord-005453-4057qib7 14848 32 . . . cord-005453-4057qib7 14849 1 It -PRON- PRP cord-005453-4057qib7 14849 2 also also RB cord-005453-4057qib7 14849 3 helps help VBZ cord-005453-4057qib7 14849 4 the the DT cord-005453-4057qib7 14849 5 donor donor NN cord-005453-4057qib7 14849 6 by by IN cord-005453-4057qib7 14849 7 decreasing decrease VBG cord-005453-4057qib7 14849 8 the the DT cord-005453-4057qib7 14849 9 total total JJ cord-005453-4057qib7 14849 10 volume volume NN cord-005453-4057qib7 14849 11 processed process VBN cord-005453-4057qib7 14849 12 , , , cord-005453-4057qib7 14849 13 amount amount NN cord-005453-4057qib7 14849 14 of of IN cord-005453-4057qib7 14849 15 ACD ACD NNP cord-005453-4057qib7 14849 16 exposure exposure NN cord-005453-4057qib7 14849 17 and and CC cord-005453-4057qib7 14849 18 the the DT cord-005453-4057qib7 14849 19 duration duration NN cord-005453-4057qib7 14849 20 of of IN cord-005453-4057qib7 14849 21 harvest harvest NN cord-005453-4057qib7 14849 22 . . . cord-005453-4057qib7 14850 1 Disclosure disclosure NN cord-005453-4057qib7 14850 2 : : : cord-005453-4057qib7 14850 3 None none NN cord-005453-4057qib7 14850 4 . . . cord-005453-4057qib7 14851 1 Impact impact NN cord-005453-4057qib7 14851 2 of of IN cord-005453-4057qib7 14851 3 vitamin vitamin NN cord-005453-4057qib7 14851 4 D d NN cord-005453-4057qib7 14851 5 levels level NNS cord-005453-4057qib7 14851 6 on on IN cord-005453-4057qib7 14851 7 peripheral peripheral JJ cord-005453-4057qib7 14851 8 stem stem NN cord-005453-4057qib7 14851 9 cell cell NN cord-005453-4057qib7 14851 10 mobilization mobilization NN cord-005453-4057qib7 14851 11 in in IN cord-005453-4057qib7 14851 12 autologous autologous JJ cord-005453-4057qib7 14851 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 14851 14 stem stem NN cord-005453-4057qib7 14851 15 cell cell NN cord-005453-4057qib7 14851 16 transplant transplant NN cord-005453-4057qib7 14851 17 recipients recipient NNS cord-005453-4057qib7 14852 1 Ferda Ferda NNP cord-005453-4057qib7 14852 2 Can Can NNP cord-005453-4057qib7 14852 3 1 1 CD cord-005453-4057qib7 14852 4 , , , cord-005453-4057qib7 14852 5 Zeynep Zeynep NNP cord-005453-4057qib7 14852 6 Arzu Arzu NNP cord-005453-4057qib7 14852 7 Yegin Yegin NNP cord-005453-4057qib7 14852 8 1 1 CD cord-005453-4057qib7 14852 9 , , , cord-005453-4057qib7 14852 10 Zubeyde Zubeyde NNP cord-005453-4057qib7 14852 11 Nur Nur NNP cord-005453-4057qib7 14852 12 Ozkurt Ozkurt NNP cord-005453-4057qib7 14852 13 1 1 CD cord-005453-4057qib7 14852 14 , , , cord-005453-4057qib7 14852 15 Orhun Orhun NNP cord-005453-4057qib7 14852 16 Akdogan Akdogan NNP cord-005453-4057qib7 14852 17 1 1 CD cord-005453-4057qib7 14852 18 , , , cord-005453-4057qib7 14852 19 Lale Lale NNP cord-005453-4057qib7 14852 20 Aydın Aydın NNP cord-005453-4057qib7 14852 21 Kaynar Kaynar NNP cord-005453-4057qib7 14852 22 1 1 CD cord-005453-4057qib7 14852 23 and and CC cord-005453-4057qib7 14852 24 total total JJ cord-005453-4057qib7 14852 25 product product NN cord-005453-4057qib7 14853 1 CD34 CD34 NNP cord-005453-4057qib7 14853 2 + + CC cord-005453-4057qib7 14853 3 cell cell NN cord-005453-4057qib7 14853 4 count count NN cord-005453-4057qib7 14853 5 [ [ -LRB- cord-005453-4057qib7 14853 6 6.7(02.8 6.7(02.8 CD cord-005453-4057qib7 14853 7 - - SYM cord-005453-4057qib7 14853 8 15 15 CD cord-005453-4057qib7 14853 9 ) ) -RRB- cord-005453-4057qib7 14853 10 vs vs IN cord-005453-4057qib7 14853 11 5.9 5.9 CD cord-005453-4057qib7 14853 12 ( ( -LRB- cord-005453-4057qib7 14853 13 2.9 2.9 CD cord-005453-4057qib7 14853 14 - - SYM cord-005453-4057qib7 14853 15 17.2 17.2 CD cord-005453-4057qib7 14853 16 ) ) -RRB- cord-005453-4057qib7 14854 1 ; ; : cord-005453-4057qib7 14854 2 p=0.047 p=0.047 NNS cord-005453-4057qib7 14854 3 ] ] -RRB- cord-005453-4057qib7 14854 4 were be VBD cord-005453-4057qib7 14854 5 significantly significantly RB cord-005453-4057qib7 14854 6 higher high JJR cord-005453-4057qib7 14854 7 in in IN cord-005453-4057qib7 14854 8 patients patient NNS cord-005453-4057qib7 14854 9 receiving receive VBG cord-005453-4057qib7 14854 10 chemotherapy+G chemotherapy+g NN cord-005453-4057qib7 14854 11 - - HYPH cord-005453-4057qib7 14854 12 CSF csf NN cord-005453-4057qib7 14854 13 than than IN cord-005453-4057qib7 14854 14 G G NNP cord-005453-4057qib7 14854 15 - - HYPH cord-005453-4057qib7 14854 16 CSF CSF NNP cord-005453-4057qib7 14854 17 only only RB cord-005453-4057qib7 14854 18 . . . cord-005453-4057qib7 14855 1 The the DT cord-005453-4057qib7 14855 2 study study NN cord-005453-4057qib7 14855 3 group group NN cord-005453-4057qib7 14855 4 was be VBD cord-005453-4057qib7 14855 5 divided divide VBN cord-005453-4057qib7 14855 6 into into IN cord-005453-4057qib7 14855 7 two two CD cord-005453-4057qib7 14855 8 groups group NNS cord-005453-4057qib7 14855 9 based base VBN cord-005453-4057qib7 14855 10 on on IN cord-005453-4057qib7 14855 11 peripheral peripheral JJ cord-005453-4057qib7 14855 12 CD34 CD34 NNP cord-005453-4057qib7 14855 13 ( ( -LRB- cord-005453-4057qib7 14855 14 cut cut VB cord-005453-4057qib7 14855 15 - - HYPH cord-005453-4057qib7 14855 16 off off RP cord-005453-4057qib7 14855 17 level level NN cord-005453-4057qib7 14855 18 : : : cord-005453-4057qib7 14855 19 20x10 20x10 CD cord-005453-4057qib7 14855 20 6 6 CD cord-005453-4057qib7 14855 21 /kg /kg . cord-005453-4057qib7 14855 22 ) ) -RRB- cord-005453-4057qib7 14855 23 as as RB cord-005453-4057qib7 14855 24 well well RB cord-005453-4057qib7 14855 25 as as IN cord-005453-4057qib7 14855 26 product product NN cord-005453-4057qib7 14855 27 CD34 CD34 NNP cord-005453-4057qib7 14855 28 levels level NNS cord-005453-4057qib7 14855 29 ( ( -LRB- cord-005453-4057qib7 14855 30 cut cut VB cord-005453-4057qib7 14855 31 - - HYPH cord-005453-4057qib7 14855 32 off off RP cord-005453-4057qib7 14855 33 level level NN cord-005453-4057qib7 14855 34 : : : cord-005453-4057qib7 14855 35 5x10 5x10 CD cord-005453-4057qib7 14855 36 6 6 CD cord-005453-4057qib7 14855 37 /kg /kg NFP cord-005453-4057qib7 14855 38 ) ) -RRB- cord-005453-4057qib7 14855 39 . . . cord-005453-4057qib7 14856 1 Vitamin vitamin NN cord-005453-4057qib7 14856 2 D d NN cord-005453-4057qib7 14856 3 levels level NNS cord-005453-4057qib7 14856 4 were be VBD cord-005453-4057qib7 14856 5 found find VBN cord-005453-4057qib7 14856 6 to to TO cord-005453-4057qib7 14856 7 be be VB cord-005453-4057qib7 14856 8 similar similar JJ cord-005453-4057qib7 14856 9 among among IN cord-005453-4057qib7 14856 10 these these DT cord-005453-4057qib7 14856 11 groups group NNS cord-005453-4057qib7 14856 12 ( ( -LRB- cord-005453-4057qib7 14856 13 p>0.05 p>0.05 NNP cord-005453-4057qib7 14856 14 ) ) -RRB- cord-005453-4057qib7 14856 15 . . . cord-005453-4057qib7 14857 1 Total total JJ cord-005453-4057qib7 14857 2 product product NN cord-005453-4057qib7 14858 1 CD34 CD34 NNP cord-005453-4057qib7 14858 2 + + CC cord-005453-4057qib7 14858 3 cell cell NN cord-005453-4057qib7 14858 4 count count NN cord-005453-4057qib7 14858 5 was be VBD cord-005453-4057qib7 14858 6 found find VBN cord-005453-4057qib7 14858 7 to to TO cord-005453-4057qib7 14858 8 be be VB cord-005453-4057qib7 14858 9 relatively relatively RB cord-005453-4057qib7 14858 10 lower low JJR cord-005453-4057qib7 14858 11 in in IN cord-005453-4057qib7 14858 12 patients patient NNS cord-005453-4057qib7 14858 13 with with IN cord-005453-4057qib7 14858 14 vitamin vitamin NN cord-005453-4057qib7 14858 15 D d NN cord-005453-4057qib7 14858 16 levels level NNS cord-005453-4057qib7 14858 17 below below IN cord-005453-4057qib7 14858 18 10 10 CD cord-005453-4057qib7 14858 19 μg μg NNP cord-005453-4057qib7 14858 20 / / SYM cord-005453-4057qib7 14858 21 L L NNP cord-005453-4057qib7 14858 22 [ [ -LRB- cord-005453-4057qib7 14858 23 5.6(3.3 5.6(3.3 CD cord-005453-4057qib7 14858 24 - - SYM cord-005453-4057qib7 14858 25 10 10 CD cord-005453-4057qib7 14858 26 ) ) -RRB- cord-005453-4057qib7 14858 27 vs vs IN cord-005453-4057qib7 14858 28 6.7(2.8 6.7(2.8 CD cord-005453-4057qib7 14858 29 - - HYPH cord-005453-4057qib7 14858 30 17.2 17.2 CD cord-005453-4057qib7 14858 31 ) ) -RRB- cord-005453-4057qib7 14858 32 ; ; : cord-005453-4057qib7 14858 33 p=0,09 p=0,09 NNP cord-005453-4057qib7 14858 34 ] ] -RRB- cord-005453-4057qib7 14858 35 . . . cord-005453-4057qib7 14859 1 ( ( -LRB- cord-005453-4057qib7 14859 2 Figure figure NN cord-005453-4057qib7 14859 3 1 1 CD cord-005453-4057qib7 14859 4 ) ) -RRB- cord-005453-4057qib7 14860 1 Conclusions conclusion NNS cord-005453-4057qib7 14860 2 : : : cord-005453-4057qib7 14861 1 Based base VBN cord-005453-4057qib7 14861 2 on on IN cord-005453-4057qib7 14861 3 its -PRON- PRP$ cord-005453-4057qib7 14861 4 effect effect NN cord-005453-4057qib7 14861 5 on on IN cord-005453-4057qib7 14861 6 stem stem NN cord-005453-4057qib7 14861 7 cells cell NNS cord-005453-4057qib7 14861 8 in in IN cord-005453-4057qib7 14861 9 in in IN cord-005453-4057qib7 14861 10 vitro vitro FW cord-005453-4057qib7 14861 11 studies study NNS cord-005453-4057qib7 14861 12 , , , cord-005453-4057qib7 14861 13 it -PRON- PRP cord-005453-4057qib7 14861 14 may may MD cord-005453-4057qib7 14861 15 be be VB cord-005453-4057qib7 14861 16 considered consider VBN cord-005453-4057qib7 14861 17 that that IN cord-005453-4057qib7 14861 18 vitamin vitamin NN cord-005453-4057qib7 14861 19 D d NN cord-005453-4057qib7 14861 20 may may MD cord-005453-4057qib7 14861 21 have have VB cord-005453-4057qib7 14861 22 a a DT cord-005453-4057qib7 14861 23 favourable favourable JJ cord-005453-4057qib7 14861 24 impact impact NN cord-005453-4057qib7 14861 25 on on IN cord-005453-4057qib7 14861 26 stem stem NN cord-005453-4057qib7 14861 27 cell cell NN cord-005453-4057qib7 14861 28 mobilization mobilization NN cord-005453-4057qib7 14861 29 . . . cord-005453-4057qib7 14862 1 Statistically statistically RB cord-005453-4057qib7 14862 2 insignificant insignificant JJ cord-005453-4057qib7 14862 3 but but CC cord-005453-4057qib7 14862 4 relatively relatively RB cord-005453-4057qib7 14862 5 lower low JJR cord-005453-4057qib7 14862 6 total total JJ cord-005453-4057qib7 14862 7 product product NN cord-005453-4057qib7 14863 1 CD34 CD34 NNP cord-005453-4057qib7 14863 2 + + CC cord-005453-4057qib7 14863 3 cell cell NN cord-005453-4057qib7 14863 4 count count NN cord-005453-4057qib7 14863 5 in in IN cord-005453-4057qib7 14863 6 patients patient NNS cord-005453-4057qib7 14863 7 who who WP cord-005453-4057qib7 14863 8 had have VBD cord-005453-4057qib7 14863 9 lower low JJR cord-005453-4057qib7 14863 10 vitamin vitamin NN cord-005453-4057qib7 14863 11 D d NN cord-005453-4057qib7 14863 12 levels level NNS cord-005453-4057qib7 14863 13 , , , cord-005453-4057qib7 14863 14 which which WDT cord-005453-4057qib7 14863 15 may may MD cord-005453-4057qib7 14863 16 indicate indicate VB cord-005453-4057qib7 14863 17 a a DT cord-005453-4057qib7 14863 18 role role NN cord-005453-4057qib7 14863 19 for for IN cord-005453-4057qib7 14863 20 vitamin vitamin NN cord-005453-4057qib7 14863 21 D d NN cord-005453-4057qib7 14863 22 in in IN cord-005453-4057qib7 14863 23 stem stem NN cord-005453-4057qib7 14863 24 cell cell NN cord-005453-4057qib7 14863 25 mobilization mobilization NN cord-005453-4057qib7 14863 26 , , , cord-005453-4057qib7 14863 27 needs need VBZ cord-005453-4057qib7 14863 28 to to TO cord-005453-4057qib7 14863 29 be be VB cord-005453-4057qib7 14863 30 confirmed confirm VBN cord-005453-4057qib7 14863 31 with with IN cord-005453-4057qib7 14863 32 larger large JJR cord-005453-4057qib7 14863 33 studies study NNS cord-005453-4057qib7 14863 34 . . . cord-005453-4057qib7 14864 1 Considering consider VBG cord-005453-4057qib7 14864 2 the the DT cord-005453-4057qib7 14864 3 high high JJ cord-005453-4057qib7 14864 4 prevalence prevalence NN cord-005453-4057qib7 14864 5 of of IN cord-005453-4057qib7 14864 6 vitamin vitamin NN cord-005453-4057qib7 14864 7 D d NN cord-005453-4057qib7 14864 8 deficiency deficiency NN cord-005453-4057qib7 14864 9 in in IN cord-005453-4057qib7 14864 10 the the DT cord-005453-4057qib7 14864 11 general general JJ cord-005453-4057qib7 14864 12 population population NN cord-005453-4057qib7 14864 13 , , , cord-005453-4057qib7 14864 14 the the DT cord-005453-4057qib7 14864 15 possible possible JJ cord-005453-4057qib7 14864 16 role role NN cord-005453-4057qib7 14864 17 of of IN cord-005453-4057qib7 14864 18 vitamin vitamin NN cord-005453-4057qib7 14864 19 D d NN cord-005453-4057qib7 14864 20 in in IN cord-005453-4057qib7 14864 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 14864 22 stem stem NN cord-005453-4057qib7 14864 23 cell cell NN cord-005453-4057qib7 14864 24 mobilization mobilization NN cord-005453-4057qib7 14864 25 deserves deserve VBZ cord-005453-4057qib7 14864 26 further further JJ cord-005453-4057qib7 14864 27 consideration consideration NN cord-005453-4057qib7 14864 28 . . . cord-005453-4057qib7 14865 1 Disclosure disclosure NN cord-005453-4057qib7 14865 2 : : : cord-005453-4057qib7 14865 3 Nothing nothing NN cord-005453-4057qib7 14865 4 to to TO cord-005453-4057qib7 14865 5 declare declare VB cord-005453-4057qib7 14865 6 Background background NN cord-005453-4057qib7 14865 7 : : : cord-005453-4057qib7 14866 1 One one CD cord-005453-4057qib7 14866 2 of of IN cord-005453-4057qib7 14866 3 the the DT cord-005453-4057qib7 14866 4 factors factor NNS cord-005453-4057qib7 14866 5 , , , cord-005453-4057qib7 14866 6 affecting affect VBG cord-005453-4057qib7 14866 7 efficiency efficiency NN cord-005453-4057qib7 14866 8 of of IN cord-005453-4057qib7 14866 9 autologous autologous JJ cord-005453-4057qib7 14866 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 14866 11 stem stem NN cord-005453-4057qib7 14866 12 cell cell NN cord-005453-4057qib7 14866 13 transplantation transplantation NN cord-005453-4057qib7 14866 14 ( ( -LRB- cord-005453-4057qib7 14866 15 autoHSCT autoHSCT NNP cord-005453-4057qib7 14866 16 ) ) -RRB- cord-005453-4057qib7 14866 17 in in IN cord-005453-4057qib7 14866 18 Hodgkin Hodgkin NNP cord-005453-4057qib7 14866 19 lymphoma lymphoma NN cord-005453-4057qib7 14866 20 ( ( -LRB- cord-005453-4057qib7 14866 21 HL HL NNP cord-005453-4057qib7 14866 22 ) ) -RRB- cord-005453-4057qib7 14866 23 patients patient NNS cord-005453-4057qib7 14866 24 is be VBZ cord-005453-4057qib7 14866 25 early early JJ cord-005453-4057qib7 14866 26 recovery recovery NN cord-005453-4057qib7 14866 27 of of IN cord-005453-4057qib7 14866 28 graft graft NN cord-005453-4057qib7 14866 29 , , , cord-005453-4057qib7 14866 30 depending depend VBG cord-005453-4057qib7 14866 31 on on IN cord-005453-4057qib7 14866 32 CD CD NNP cord-005453-4057qib7 14866 33 34 34 CD cord-005453-4057qib7 14866 34 + + CD cord-005453-4057qib7 14866 35 cell cell NN cord-005453-4057qib7 14866 36 count count NN cord-005453-4057qib7 14866 37 and and CC cord-005453-4057qib7 14866 38 conditions condition NNS cord-005453-4057qib7 14866 39 of of IN cord-005453-4057qib7 14866 40 cell cell NN cord-005453-4057qib7 14866 41 product product NN cord-005453-4057qib7 14866 42 cryopreservation cryopreservation NN cord-005453-4057qib7 14866 43 and and CC cord-005453-4057qib7 14866 44 storage storage NN cord-005453-4057qib7 14866 45 . . . cord-005453-4057qib7 14867 1 It -PRON- PRP cord-005453-4057qib7 14867 2 is be VBZ cord-005453-4057qib7 14867 3 well well RB cord-005453-4057qib7 14867 4 known known JJ cord-005453-4057qib7 14867 5 , , , cord-005453-4057qib7 14867 6 that that IN cord-005453-4057qib7 14867 7 dimethylsulfoxide dimethylsulfoxide NN cord-005453-4057qib7 14867 8 ( ( -LRB- cord-005453-4057qib7 14867 9 DMSO DMSO NNP cord-005453-4057qib7 14867 10 ) ) -RRB- cord-005453-4057qib7 14867 11 , , , cord-005453-4057qib7 14867 12 used use VBN cord-005453-4057qib7 14867 13 for for IN cord-005453-4057qib7 14867 14 cryopreservation cryopreservation NN cord-005453-4057qib7 14867 15 , , , cord-005453-4057qib7 14867 16 can can MD cord-005453-4057qib7 14867 17 be be VB cord-005453-4057qib7 14867 18 cardiotoxic cardiotoxic JJ cord-005453-4057qib7 14867 19 and and CC cord-005453-4057qib7 14867 20 cause cause VB cord-005453-4057qib7 14868 1 diverse diverse JJ cord-005453-4057qib7 14868 2 gastrointestinal gastrointestinal JJ cord-005453-4057qib7 14868 3 , , , cord-005453-4057qib7 14868 4 pulmonary pulmonary JJ cord-005453-4057qib7 14868 5 , , , cord-005453-4057qib7 14868 6 kidney kidney NN cord-005453-4057qib7 14868 7 , , , cord-005453-4057qib7 14868 8 liver liver NN cord-005453-4057qib7 14868 9 side side NN cord-005453-4057qib7 14868 10 effects effect NNS cord-005453-4057qib7 14868 11 and and CC cord-005453-4057qib7 14868 12 acute acute JJ cord-005453-4057qib7 14868 13 hemolysis hemolysis NN cord-005453-4057qib7 14868 14 . . . cord-005453-4057qib7 14869 1 Lethal lethal JJ cord-005453-4057qib7 14869 2 for for IN cord-005453-4057qib7 14869 3 animals animal NNS cord-005453-4057qib7 14869 4 dose dose VBP cord-005453-4057qib7 14870 1 30 30 CD cord-005453-4057qib7 14870 2 - - SYM cord-005453-4057qib7 14870 3 40 40 CD cord-005453-4057qib7 14870 4 mg mg NNP cord-005453-4057qib7 14870 5 / / SYM cord-005453-4057qib7 14870 6 kg kg NNP cord-005453-4057qib7 14870 7 leads lead VBZ cord-005453-4057qib7 14870 8 to to IN cord-005453-4057qib7 14870 9 life life NN cord-005453-4057qib7 14870 10 threatening threaten VBG cord-005453-4057qib7 14870 11 arrhythmias arrhythmia NNS cord-005453-4057qib7 14870 12 and and CC cord-005453-4057qib7 14870 13 respiratory respiratory JJ cord-005453-4057qib7 14870 14 arrest arrest NN cord-005453-4057qib7 14870 15 . . . cord-005453-4057qib7 14871 1 In in IN cord-005453-4057qib7 14871 2 order order NN cord-005453-4057qib7 14871 3 to to TO cord-005453-4057qib7 14871 4 improve improve VB cord-005453-4057qib7 14871 5 DMSO DMSO NNP cord-005453-4057qib7 14871 6 toxicity toxicity NN cord-005453-4057qib7 14871 7 different different JJ cord-005453-4057qib7 14871 8 ways way NNS cord-005453-4057qib7 14871 9 of of IN cord-005453-4057qib7 14871 10 alternative alternative JJ cord-005453-4057qib7 14871 11 cryoconservation cryoconservation NN cord-005453-4057qib7 14871 12 modes mode NNS cord-005453-4057qib7 14871 13 are be VBP cord-005453-4057qib7 14871 14 studied study VBN cord-005453-4057qib7 14871 15 -lower -lower . cord-005453-4057qib7 14872 1 DMSO DMSO NNP cord-005453-4057qib7 14872 2 concentration concentration NN cord-005453-4057qib7 14872 3 ( ( -LRB- cord-005453-4057qib7 14872 4 5 5 CD cord-005453-4057qib7 14872 5 % % NN cord-005453-4057qib7 14872 6 VS VS NNP cord-005453-4057qib7 14872 7 10 10 CD cord-005453-4057qib7 14872 8 % % NN cord-005453-4057qib7 14872 9 ) ) -RRB- cord-005453-4057qib7 14872 10 , , , cord-005453-4057qib7 14872 11 temperature temperature NN cord-005453-4057qib7 14872 12 -80˚C -80˚c NN cord-005453-4057qib7 14872 13 instead instead RB cord-005453-4057qib7 14872 14 of of IN cord-005453-4057qib7 14872 15 ultra ultra JJ cord-005453-4057qib7 14872 16 - - JJ cord-005453-4057qib7 14872 17 low low JJ cord-005453-4057qib7 14872 18 and and CC cord-005453-4057qib7 14872 19 washing washing NN cord-005453-4057qib7 14872 20 of of IN cord-005453-4057qib7 14872 21 cell cell NN cord-005453-4057qib7 14872 22 product product NN cord-005453-4057qib7 14872 23 . . . cord-005453-4057qib7 14873 1 Aim Aim NNP cord-005453-4057qib7 14873 2 of of IN cord-005453-4057qib7 14873 3 the the DT cord-005453-4057qib7 14873 4 study study NN cord-005453-4057qib7 14873 5 is be VBZ cord-005453-4057qib7 14873 6 to to TO cord-005453-4057qib7 14873 7 evaluate evaluate VB cord-005453-4057qib7 14873 8 the the DT cord-005453-4057qib7 14873 9 influence influence NN cord-005453-4057qib7 14873 10 of of IN cord-005453-4057qib7 14873 11 DMSO DMSO NNP cord-005453-4057qib7 14873 12 washing wash VBG cord-005453-4057qib7 14873 13 on on IN cord-005453-4057qib7 14873 14 hematopoietic hematopoietic JJ cord-005453-4057qib7 14873 15 recovery recovery NN cord-005453-4057qib7 14873 16 after after IN cord-005453-4057qib7 14873 17 autoHSCT autoHSCT NNP cord-005453-4057qib7 14873 18 . . . cord-005453-4057qib7 14874 1 Methods method NNS cord-005453-4057qib7 14874 2 : : : cord-005453-4057qib7 14875 1 Retrospective retrospective JJ cord-005453-4057qib7 14875 2 analysis analysis NN cord-005453-4057qib7 14875 3 of of IN cord-005453-4057qib7 14875 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 14875 5 recovery recovery NN cord-005453-4057qib7 14875 6 of of IN cord-005453-4057qib7 14875 7 37 37 CD cord-005453-4057qib7 14875 8 relapse relapse NN cord-005453-4057qib7 14875 9 / / SYM cord-005453-4057qib7 14875 10 refractory refractory JJ cord-005453-4057qib7 14875 11 HL HL NNP cord-005453-4057qib7 14875 12 patients patient NNS cord-005453-4057qib7 14875 13 after after IN cord-005453-4057qib7 14875 14 autoHSCT autoHSCT NNP cord-005453-4057qib7 14875 15 was be VBD cord-005453-4057qib7 14875 16 performed perform VBN cord-005453-4057qib7 14875 17 . . . cord-005453-4057qib7 14876 1 Mobilization mobilization NN cord-005453-4057qib7 14876 2 regimen regimen NN cord-005453-4057qib7 14876 3 included include VBD cord-005453-4057qib7 14876 4 second second JJ cord-005453-4057qib7 14876 5 line line NN cord-005453-4057qib7 14876 6 chemotherapy chemotherapy NN cord-005453-4057qib7 14876 7 for for IN cord-005453-4057qib7 14876 8 HL HL NNP cord-005453-4057qib7 14876 9 ( ( -LRB- cord-005453-4057qib7 14876 10 DHAP DHAP NNP cord-005453-4057qib7 14876 11 , , , cord-005453-4057qib7 14876 12 BeGEV begev UH cord-005453-4057qib7 14876 13 , , , cord-005453-4057qib7 14876 14 IGEV IGEV NNP cord-005453-4057qib7 14876 15 , , , cord-005453-4057qib7 14876 16 ICE ice NN cord-005453-4057qib7 14876 17 ) ) -RRB- cord-005453-4057qib7 14876 18 with with IN cord-005453-4057qib7 14876 19 consecutive consecutive JJ cord-005453-4057qib7 14876 20 G G NNP cord-005453-4057qib7 14876 21 - - HYPH cord-005453-4057qib7 14876 22 CSF CSF NNP cord-005453-4057qib7 14876 23 administration administration NN cord-005453-4057qib7 14876 24 . . . cord-005453-4057qib7 14877 1 CD CD NNP cord-005453-4057qib7 14877 2 34 34 CD cord-005453-4057qib7 14877 3 + + SYM cord-005453-4057qib7 14877 4 cells cell NNS cord-005453-4057qib7 14877 5 were be VBD cord-005453-4057qib7 14877 6 assessed assess VBN cord-005453-4057qib7 14877 7 , , , cord-005453-4057qib7 14877 8 using use VBG cord-005453-4057qib7 14877 9 6-colour 6-colour CD cord-005453-4057qib7 14877 10 flow flow NN cord-005453-4057qib7 14877 11 cytometer cytometer NN cord-005453-4057qib7 14877 12 FACS FACS NNP cord-005453-4057qib7 14877 13 Canto Canto NNP cord-005453-4057qib7 14877 14 II II NNP cord-005453-4057qib7 14877 15 while while IN cord-005453-4057qib7 14877 16 cell cell NN cord-005453-4057qib7 14877 17 collection collection NN cord-005453-4057qib7 14877 18 , , , cord-005453-4057qib7 14877 19 thawing thawing NN cord-005453-4057qib7 14877 20 and and CC cord-005453-4057qib7 14877 21 washing washing NN cord-005453-4057qib7 14877 22 . . . cord-005453-4057qib7 14878 1 Cells cell NNS cord-005453-4057qib7 14878 2 with with IN cord-005453-4057qib7 14878 3 10 10 CD cord-005453-4057qib7 14878 4 % % NN cord-005453-4057qib7 14878 5 DMSO DMSO NNP cord-005453-4057qib7 14878 6 were be VBD cord-005453-4057qib7 14878 7 stored store VBN cord-005453-4057qib7 14878 8 at at IN cord-005453-4057qib7 14878 9 -196˚and -196˚and : cord-005453-4057qib7 14878 10 washed wash VBN cord-005453-4057qib7 14878 11 in in IN cord-005453-4057qib7 14878 12 14 14 CD cord-005453-4057qib7 14878 13 cases case NNS cord-005453-4057qib7 14878 14 of of IN cord-005453-4057qib7 14878 15 transplantation transplantation NN cord-005453-4057qib7 14878 16 with with IN cord-005453-4057qib7 14878 17 human human JJ cord-005453-4057qib7 14878 18 albumin albumin NN cord-005453-4057qib7 14878 19 - - HYPH cord-005453-4057qib7 14878 20 dextran dextran NN cord-005453-4057qib7 14878 21 ( ( -LRB- cord-005453-4057qib7 14878 22 Reopolyglukin Reopolyglukin NNP cord-005453-4057qib7 14878 23 ) ) -RRB- cord-005453-4057qib7 14878 24 and and CC cord-005453-4057qib7 14878 25 centrifugation centrifugation NN cord-005453-4057qib7 14878 26 . . . cord-005453-4057qib7 14879 1 Statistical statistical JJ cord-005453-4057qib7 14879 2 data datum NNS cord-005453-4057qib7 14879 3 processing processing NN cord-005453-4057qib7 14879 4 was be VBD cord-005453-4057qib7 14879 5 performed perform VBN cord-005453-4057qib7 14879 6 by by IN cord-005453-4057qib7 14879 7 the the DT cord-005453-4057qib7 14879 8 χ2 χ2 NNP cord-005453-4057qib7 14879 9 method method NN cord-005453-4057qib7 14879 10 -Pearson -pearson NN cord-005453-4057qib7 14879 11 criterion criterion NN cord-005453-4057qib7 14879 12 ; ; : cord-005453-4057qib7 14879 13 p p NN cord-005453-4057qib7 14879 14 -the -the DT cord-005453-4057qib7 14879 15 level level NN cord-005453-4057qib7 14879 16 of of IN cord-005453-4057qib7 14879 17 significance significance NN cord-005453-4057qib7 14879 18 of of IN cord-005453-4057qib7 14879 19 differences difference NNS cord-005453-4057qib7 14879 20 . . . cord-005453-4057qib7 14880 1 Results result NNS cord-005453-4057qib7 14880 2 : : : cord-005453-4057qib7 14881 1 Patient patient JJ cord-005453-4057qib7 14881 2 groups group NNS cord-005453-4057qib7 14881 3 had have VBD cord-005453-4057qib7 14881 4 no no DT cord-005453-4057qib7 14881 5 difference difference NN cord-005453-4057qib7 14881 6 in in IN cord-005453-4057qib7 14881 7 age age NN cord-005453-4057qib7 14881 8 , , , cord-005453-4057qib7 14881 9 disease disease NN cord-005453-4057qib7 14881 10 stage stage NN cord-005453-4057qib7 14881 11 , , , cord-005453-4057qib7 14881 12 gender gender NN cord-005453-4057qib7 14881 13 , , , cord-005453-4057qib7 14881 14 time time NN cord-005453-4057qib7 14881 15 from from IN cord-005453-4057qib7 14881 16 treatment treatment NN cord-005453-4057qib7 14881 17 start start NN cord-005453-4057qib7 14881 18 to to IN cord-005453-4057qib7 14881 19 autoHSCT autoHSCT NNP cord-005453-4057qib7 14881 20 and and CC cord-005453-4057qib7 14881 21 CD34 CD34 NNP cord-005453-4057qib7 14881 22 + + CC cord-005453-4057qib7 14881 23 cell cell NN cord-005453-4057qib7 14881 24 count count NN cord-005453-4057qib7 14881 25 ( ( -LRB- cord-005453-4057qib7 14881 26 p>0,05 p>0,05 NNP cord-005453-4057qib7 14881 27 ) ) -RRB- cord-005453-4057qib7 14881 28 . . . cord-005453-4057qib7 14882 1 Time time NN cord-005453-4057qib7 14882 2 to to IN cord-005453-4057qib7 14882 3 WBC WBC NNP cord-005453-4057qib7 14882 4 recovery recovery NN cord-005453-4057qib7 14882 5 > > XX cord-005453-4057qib7 14883 1 1х10 1х10 CD cord-005453-4057qib7 14883 2 9 9 CD cord-005453-4057qib7 14883 3 /л /л NNP cord-005453-4057qib7 14883 4 was be VBD cord-005453-4057qib7 14883 5 9 9 CD cord-005453-4057qib7 14883 6 - - SYM cord-005453-4057qib7 14883 7 29 29 CD cord-005453-4057qib7 14884 1 ( ( -LRB- cord-005453-4057qib7 14884 2 median median NN cord-005453-4057qib7 14884 3 13,6 13,6 CD cord-005453-4057qib7 14884 4 ) ) -RRB- cord-005453-4057qib7 14884 5 days day NNS cord-005453-4057qib7 14884 6 vs vs IN cord-005453-4057qib7 14884 7 10 10 CD cord-005453-4057qib7 14884 8 - - SYM cord-005453-4057qib7 14884 9 34 34 CD cord-005453-4057qib7 14884 10 ( ( -LRB- cord-005453-4057qib7 14884 11 median median JJ cord-005453-4057qib7 14884 12 13,7 13,7 CD cord-005453-4057qib7 14884 13 ) ) -RRB- cord-005453-4057qib7 14884 14 days day NNS cord-005453-4057qib7 14884 15 , , , cord-005453-4057qib7 14884 16 time time NN cord-005453-4057qib7 14884 17 to to IN cord-005453-4057qib7 14884 18 platelet>30х10 platelet>30х10 NN cord-005453-4057qib7 14884 19 9 9 CD cord-005453-4057qib7 14884 20 /л /л NNP cord-005453-4057qib7 14884 21 recovery recovery NN cord-005453-4057qib7 14884 22 was be VBD cord-005453-4057qib7 14884 23 11 11 CD cord-005453-4057qib7 14884 24 - - SYM cord-005453-4057qib7 14884 25 34 34 CD cord-005453-4057qib7 14884 26 ( ( -LRB- cord-005453-4057qib7 14884 27 median median NN cord-005453-4057qib7 14884 28 16,9 16,9 CD cord-005453-4057qib7 14884 29 ) ) -RRB- cord-005453-4057qib7 14884 30 days day NNS cord-005453-4057qib7 14884 31 vs vs IN cord-005453-4057qib7 14884 32 11 11 CD cord-005453-4057qib7 14884 33 - - SYM cord-005453-4057qib7 14884 34 58 58 CD cord-005453-4057qib7 14884 35 ( ( -LRB- cord-005453-4057qib7 14884 36 median median NN cord-005453-4057qib7 14884 37 17,9 17,9 CD cord-005453-4057qib7 14884 38 ) ) -RRB- cord-005453-4057qib7 14884 39 days day NNS cord-005453-4057qib7 14884 40 in in IN cord-005453-4057qib7 14884 41 groups group NNS cord-005453-4057qib7 14884 42 without without IN cord-005453-4057qib7 14884 43 and and CC cord-005453-4057qib7 14884 44 with with IN cord-005453-4057qib7 14884 45 cell cell NN cord-005453-4057qib7 14884 46 washing washing NN cord-005453-4057qib7 14884 47 respectively respectively RB cord-005453-4057qib7 14884 48 ( ( -LRB- cord-005453-4057qib7 14884 49 p=0,507 p=0,507 NNP cord-005453-4057qib7 14884 50 ) ) -RRB- cord-005453-4057qib7 14884 51 . . . cord-005453-4057qib7 14885 1 No no DT cord-005453-4057qib7 14885 2 difference difference NN cord-005453-4057qib7 14885 3 in in IN cord-005453-4057qib7 14885 4 blood blood NN cord-005453-4057qib7 14885 5 component component NN cord-005453-4057qib7 14885 6 consumption consumption NN cord-005453-4057qib7 14885 7 was be VBD cord-005453-4057qib7 14885 8 observed observe VBN cord-005453-4057qib7 14885 9 ( ( -LRB- cord-005453-4057qib7 14885 10 p=0,546 p=0,546 NNP cord-005453-4057qib7 14885 11 ) ) -RRB- cord-005453-4057qib7 14885 12 . . . cord-005453-4057qib7 14886 1 In in IN cord-005453-4057qib7 14886 2 18 18 CD cord-005453-4057qib7 14886 3 out out IN cord-005453-4057qib7 14886 4 of of IN cord-005453-4057qib7 14886 5 23 23 CD cord-005453-4057qib7 14886 6 ( ( -LRB- cord-005453-4057qib7 14886 7 78 78 CD cord-005453-4057qib7 14886 8 % % NN cord-005453-4057qib7 14886 9 ) ) -RRB- cord-005453-4057qib7 14886 10 patients patient NNS cord-005453-4057qib7 14886 11 during during IN cord-005453-4057qib7 14886 12 cell cell NN cord-005453-4057qib7 14886 13 reinfusion reinfusion NN cord-005453-4057qib7 14886 14 without without IN cord-005453-4057qib7 14886 15 washing wash VBG cord-005453-4057qib7 14886 16 nausea nausea NN cord-005453-4057qib7 14886 17 , , , cord-005453-4057qib7 14886 18 vomiting vomiting NN cord-005453-4057qib7 14886 19 , , , cord-005453-4057qib7 14886 20 arterial arterial JJ cord-005453-4057qib7 14886 21 hypertension hypertension NN cord-005453-4057qib7 14886 22 was be VBD cord-005453-4057qib7 14886 23 observed observe VBN cord-005453-4057qib7 14886 24 , , , cord-005453-4057qib7 14886 25 no no DT cord-005453-4057qib7 14886 26 reactions reaction NNS cord-005453-4057qib7 14886 27 were be VBD cord-005453-4057qib7 14886 28 detected detect VBN cord-005453-4057qib7 14886 29 after after IN cord-005453-4057qib7 14886 30 cell cell NN cord-005453-4057qib7 14886 31 washing washing NN cord-005453-4057qib7 14886 32 ( ( -LRB- cord-005453-4057qib7 14886 33 p p NN cord-005453-4057qib7 14886 34 = = SYM cord-005453-4057qib7 14886 35 0,03 0,03 CD cord-005453-4057qib7 14886 36 ) ) -RRB- cord-005453-4057qib7 14886 37 . . . cord-005453-4057qib7 14887 1 Conclusions conclusion NNS cord-005453-4057qib7 14887 2 : : : cord-005453-4057qib7 14888 1 Washing wash VBG cord-005453-4057qib7 14888 2 autologous autologous JJ cord-005453-4057qib7 14888 3 mononuclear mononuclear JJ cord-005453-4057qib7 14888 4 cells cell NNS cord-005453-4057qib7 14888 5 from from IN cord-005453-4057qib7 14888 6 cryopreservant cryopreservant JJ cord-005453-4057qib7 14888 7 DMSO DMSO NNP cord-005453-4057qib7 14888 8 does do VBZ cord-005453-4057qib7 14888 9 not not RB cord-005453-4057qib7 14888 10 lead lead VB cord-005453-4057qib7 14888 11 to to IN cord-005453-4057qib7 14888 12 low low JJ cord-005453-4057qib7 14888 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 14888 14 recovery recovery NN cord-005453-4057qib7 14888 15 rate rate NN cord-005453-4057qib7 14888 16 after after IN cord-005453-4057qib7 14888 17 autoHSCT autoHSCT NNP cord-005453-4057qib7 14888 18 and and CC cord-005453-4057qib7 14888 19 can can MD cord-005453-4057qib7 14888 20 avoid avoid VB cord-005453-4057qib7 14888 21 toxicity toxicity NN cord-005453-4057qib7 14888 22 , , , cord-005453-4057qib7 14888 23 thus thus RB cord-005453-4057qib7 14888 24 making make VBG cord-005453-4057qib7 14888 25 autoHSCT autohsct RB cord-005453-4057qib7 14888 26 more more RBR cord-005453-4057qib7 14888 27 safe safe JJ cord-005453-4057qib7 14888 28 . . . cord-005453-4057qib7 14889 1 Disclosure disclosure NN cord-005453-4057qib7 14889 2 : : : cord-005453-4057qib7 14890 1 authors author NNS cord-005453-4057qib7 14890 2 declare declare VBP cord-005453-4057qib7 14890 3 no no DT cord-005453-4057qib7 14890 4 conflict conflict NN cord-005453-4057qib7 14890 5 of of IN cord-005453-4057qib7 14890 6 interests interest NNS cord-005453-4057qib7 14890 7 . . . cord-005453-4057qib7 14891 1 Quality Quality NNP cord-005453-4057qib7 14891 2 assesment assesment NN cord-005453-4057qib7 14891 3 of of IN cord-005453-4057qib7 14891 4 hematopoietic hematopoietic JJ cord-005453-4057qib7 14891 5 stem stem NN cord-005453-4057qib7 14891 6 cells cell NNS cord-005453-4057qib7 14891 7 autografts autografts NNP cord-005453-4057qib7 14891 8 after after IN cord-005453-4057qib7 14891 9 cryostorage cryostorage NN cord-005453-4057qib7 14891 10 , , , cord-005453-4057qib7 14891 11 harvested harvest VBN cord-005453-4057qib7 14891 12 using use VBG cord-005453-4057qib7 14891 13 plerixafor plerixafor NN cord-005453-4057qib7 14891 14 Background Background NNP cord-005453-4057qib7 14891 15 : : : cord-005453-4057qib7 14892 1 The the DT cord-005453-4057qib7 14892 2 introduction introduction NN cord-005453-4057qib7 14892 3 of of IN cord-005453-4057qib7 14892 4 high high JJ cord-005453-4057qib7 14892 5 - - HYPH cord-005453-4057qib7 14892 6 dose dose NN cord-005453-4057qib7 14892 7 chemotherapy chemotherapy NN cord-005453-4057qib7 14892 8 followed follow VBN cord-005453-4057qib7 14892 9 by by IN cord-005453-4057qib7 14892 10 transplantation transplantation NN cord-005453-4057qib7 14892 11 of of IN cord-005453-4057qib7 14892 12 autologous autologous JJ cord-005453-4057qib7 14892 13 hemopoietic hemopoietic JJ cord-005453-4057qib7 14892 14 stem stem NN cord-005453-4057qib7 14892 15 cells cell NNS cord-005453-4057qib7 14892 16 ( ( -LRB- cord-005453-4057qib7 14892 17 HSCs hscs NN cord-005453-4057qib7 14892 18 ) ) -RRB- cord-005453-4057qib7 14892 19 into into IN cord-005453-4057qib7 14892 20 the the DT cord-005453-4057qib7 14892 21 treatment treatment NN cord-005453-4057qib7 14892 22 program program NN cord-005453-4057qib7 14892 23 for for IN cord-005453-4057qib7 14892 24 multiple multiple JJ cord-005453-4057qib7 14892 25 myeloma myeloma NN cord-005453-4057qib7 14892 26 ( ( -LRB- cord-005453-4057qib7 14892 27 MM MM NNP cord-005453-4057qib7 14892 28 ) ) -RRB- cord-005453-4057qib7 14892 29 has have VBZ cord-005453-4057qib7 14892 30 significantly significantly RB cord-005453-4057qib7 14892 31 increased increase VBN cord-005453-4057qib7 14892 32 the the DT cord-005453-4057qib7 14892 33 frequency frequency NN cord-005453-4057qib7 14892 34 of of IN cord-005453-4057qib7 14892 35 achieving achieve VBG cord-005453-4057qib7 14892 36 complete complete JJ cord-005453-4057qib7 14892 37 remissions remission NNS cord-005453-4057qib7 14892 38 and and CC cord-005453-4057qib7 14892 39 overall overall JJ cord-005453-4057qib7 14892 40 survival survival NN cord-005453-4057qib7 14892 41 in in IN cord-005453-4057qib7 14892 42 patients patient NNS cord-005453-4057qib7 14892 43 . . . cord-005453-4057qib7 14893 1 To to TO cord-005453-4057qib7 14893 2 obtain obtain VB cord-005453-4057qib7 14893 3 a a DT cord-005453-4057qib7 14893 4 sufficient sufficient JJ cord-005453-4057qib7 14893 5 amount amount NN cord-005453-4057qib7 14893 6 of of IN cord-005453-4057qib7 14893 7 HSCs hscs NN cord-005453-4057qib7 14893 8 , , , cord-005453-4057qib7 14893 9 hematopoiesis hematopoiesis NN cord-005453-4057qib7 14893 10 is be VBZ cord-005453-4057qib7 14893 11 stimulated stimulate VBN cord-005453-4057qib7 14893 12 with with IN cord-005453-4057qib7 14893 13 granulocyte granulocyte NN cord-005453-4057qib7 14893 14 - - HYPH cord-005453-4057qib7 14893 15 macrophage macrophage NN cord-005453-4057qib7 14893 16 factors factor NNS cord-005453-4057qib7 14893 17 ( ( -LRB- cord-005453-4057qib7 14893 18 GM GM NNP cord-005453-4057qib7 14893 19 - - HYPH cord-005453-4057qib7 14893 20 CSF CSF NNP cord-005453-4057qib7 14893 21 ) ) -RRB- cord-005453-4057qib7 14894 1 both both DT cord-005453-4057qib7 14894 2 in in IN cord-005453-4057qib7 14894 3 mono mono NN cord-005453-4057qib7 14894 4 mode mode NN cord-005453-4057qib7 14894 5 and and CC cord-005453-4057qib7 14894 6 after after IN cord-005453-4057qib7 14894 7 the the DT cord-005453-4057qib7 14894 8 administration administration NN cord-005453-4057qib7 14894 9 of of IN cord-005453-4057qib7 14894 10 cytostatics cytostatics NNP cord-005453-4057qib7 14894 11 followed follow VBN cord-005453-4057qib7 14894 12 by by IN cord-005453-4057qib7 14894 13 cytapheresis cytapheresis NN cord-005453-4057qib7 14894 14 sessions session NNS cord-005453-4057qib7 14894 15 ( ( -LRB- cord-005453-4057qib7 14894 16 alone alone RB cord-005453-4057qib7 14894 17 or or CC cord-005453-4057qib7 14894 18 after after IN cord-005453-4057qib7 14894 19 the the DT cord-005453-4057qib7 14894 20 cytostatics cytostatic NNS cord-005453-4057qib7 14894 21 followed follow VBN cord-005453-4057qib7 14894 22 by by IN cord-005453-4057qib7 14894 23 cytapheresis cytapheresis NN cord-005453-4057qib7 14894 24 sessions session NNS cord-005453-4057qib7 14894 25 ) ) -RRB- cord-005453-4057qib7 14894 26 . . . cord-005453-4057qib7 14895 1 Cryopreservation cryopreservation NN cord-005453-4057qib7 14895 2 protocols protocol NNS cord-005453-4057qib7 14895 3 are be VBP cord-005453-4057qib7 14895 4 used use VBN cord-005453-4057qib7 14895 5 to to TO cord-005453-4057qib7 14895 6 preserve preserve VB cord-005453-4057qib7 14895 7 cells cell NNS cord-005453-4057qib7 14895 8 in in IN cord-005453-4057qib7 14895 9 a a DT cord-005453-4057qib7 14895 10 viable viable JJ cord-005453-4057qib7 14895 11 state state NN cord-005453-4057qib7 14895 12 , , , cord-005453-4057qib7 14895 13 followed follow VBN cord-005453-4057qib7 14895 14 by by IN cord-005453-4057qib7 14895 15 long long JJ cord-005453-4057qib7 14895 16 - - HYPH cord-005453-4057qib7 14895 17 term term NN cord-005453-4057qib7 14895 18 storage storage NN cord-005453-4057qib7 14895 19 of of IN cord-005453-4057qib7 14895 20 transplants transplant NNS cord-005453-4057qib7 14895 21 in in IN cord-005453-4057qib7 14895 22 liquid liquid JJ cord-005453-4057qib7 14895 23 nitrogen nitrogen NN cord-005453-4057qib7 14895 24 . . . cord-005453-4057qib7 14896 1 However however RB cord-005453-4057qib7 14896 2 , , , cord-005453-4057qib7 14896 3 in in IN cord-005453-4057qib7 14896 4 some some DT cord-005453-4057qib7 14896 5 patients patient NNS cord-005453-4057qib7 14896 6 it -PRON- PRP cord-005453-4057qib7 14896 7 is be VBZ cord-005453-4057qib7 14896 8 not not RB cord-005453-4057qib7 14896 9 possible possible JJ cord-005453-4057qib7 14896 10 to to TO cord-005453-4057qib7 14896 11 obtain obtain VB cord-005453-4057qib7 14896 12 the the DT cord-005453-4057qib7 14896 13 necessary necessary JJ cord-005453-4057qib7 14896 14 amount amount NN cord-005453-4057qib7 14896 15 of of IN cord-005453-4057qib7 14896 16 HSCs hscs NN cord-005453-4057qib7 14896 17 . . . cord-005453-4057qib7 14897 1 The the DT cord-005453-4057qib7 14897 2 inclusion inclusion NN cord-005453-4057qib7 14897 3 of of IN cord-005453-4057qib7 14897 4 plerixafor plerixafor NN cord-005453-4057qib7 14897 5 in in IN cord-005453-4057qib7 14897 6 standard standard JJ cord-005453-4057qib7 14897 7 mobilization mobilization NN cord-005453-4057qib7 14897 8 schemes scheme NNS cord-005453-4057qib7 14897 9 allows allow VBZ cord-005453-4057qib7 14897 10 you -PRON- PRP cord-005453-4057qib7 14897 11 to to TO cord-005453-4057qib7 14897 12 prepare prepare VB cord-005453-4057qib7 14897 13 the the DT cord-005453-4057qib7 14897 14 sufficient sufficient JJ cord-005453-4057qib7 14897 15 quantity quantity NN cord-005453-4057qib7 14897 16 of of IN cord-005453-4057qib7 14897 17 HSCs hscs NN cord-005453-4057qib7 14897 18 in in IN cord-005453-4057qib7 14897 19 most most JJS cord-005453-4057qib7 14897 20 patients patient NNS cord-005453-4057qib7 14897 21 with with IN cord-005453-4057qib7 14897 22 MM MM NNP cord-005453-4057qib7 14897 23 . . . cord-005453-4057qib7 14898 1 Methods method NNS cord-005453-4057qib7 14898 2 : : : cord-005453-4057qib7 14899 1 The the DT cord-005453-4057qib7 14899 2 study study NN cord-005453-4057qib7 14899 3 included include VBD cord-005453-4057qib7 14899 4 18 18 CD cord-005453-4057qib7 14899 5 samples sample NNS cord-005453-4057qib7 14899 6 of of IN cord-005453-4057qib7 14899 7 autografts autografts NNP cord-005453-4057qib7 14899 8 from from IN cord-005453-4057qib7 14899 9 18 18 CD cord-005453-4057qib7 14899 10 patients patient NNS cord-005453-4057qib7 14899 11 with with IN cord-005453-4057qib7 14899 12 MM MM NNP cord-005453-4057qib7 14899 13 from from IN cord-005453-4057qib7 14899 14 2015 2015 CD cord-005453-4057qib7 14899 15 to to IN cord-005453-4057qib7 14899 16 2017 2017 CD cord-005453-4057qib7 14899 17 ( ( -LRB- cord-005453-4057qib7 14899 18 Median Median NNP cord-005453-4057qib7 14899 19 2.1 2.1 CD cord-005453-4057qib7 14899 20 ± ± CD cord-005453-4057qib7 14899 21 0.3 0.3 CD cord-005453-4057qib7 14899 22 ) ) -RRB- cord-005453-4057qib7 14899 23 . . . cord-005453-4057qib7 14900 1 HSCs HSCs NNP cord-005453-4057qib7 14900 2 mobilization mobilization NN cord-005453-4057qib7 14900 3 was be VBD cord-005453-4057qib7 14900 4 performed perform VBN cord-005453-4057qib7 14900 5 on on IN cord-005453-4057qib7 14900 6 the the DT cord-005453-4057qib7 14900 7 background background NN cord-005453-4057qib7 14900 8 of of IN cord-005453-4057qib7 14900 9 unstable unstable JJ cord-005453-4057qib7 14900 10 blood blood NN cord-005453-4057qib7 14900 11 formation formation NN cord-005453-4057qib7 14900 12 after after IN cord-005453-4057qib7 14900 13 high high JJ cord-005453-4057qib7 14900 14 doses dose NNS cord-005453-4057qib7 14900 15 of of IN cord-005453-4057qib7 14900 16 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 14900 17 6 6 CD cord-005453-4057qib7 14900 18 g g NN cord-005453-4057qib7 14900 19 / / SYM cord-005453-4057qib7 14900 20 m m NN cord-005453-4057qib7 14900 21 2 2 CD cord-005453-4057qib7 14900 22 with with IN cord-005453-4057qib7 14900 23 the the DT cord-005453-4057qib7 14900 24 subsequent subsequent JJ cord-005453-4057qib7 14900 25 administration administration NN cord-005453-4057qib7 14900 26 of of IN cord-005453-4057qib7 14900 27 G G NNP cord-005453-4057qib7 14900 28 - - HYPH cord-005453-4057qib7 14900 29 CSF CSF NNP cord-005453-4057qib7 14900 30 at at IN cord-005453-4057qib7 14900 31 a a DT cord-005453-4057qib7 14900 32 dose dose NN cord-005453-4057qib7 14900 33 of of IN cord-005453-4057qib7 14900 34 12 12 CD cord-005453-4057qib7 14900 35 - - SYM cord-005453-4057qib7 14900 36 24 24 CD cord-005453-4057qib7 14900 37 μg μg NNP cord-005453-4057qib7 14900 38 / / SYM cord-005453-4057qib7 14900 39 kg kg NN cord-005453-4057qib7 14900 40 ( ( -LRB- cord-005453-4057qib7 14900 41 9 9 CD cord-005453-4057qib7 14900 42 samples sample NNS cord-005453-4057qib7 14900 43 from from IN cord-005453-4057qib7 14900 44 9 9 CD cord-005453-4057qib7 14900 45 patients patient NNS cord-005453-4057qib7 14900 46 ) ) -RRB- cord-005453-4057qib7 14900 47 and and CC cord-005453-4057qib7 14900 48 with with IN cord-005453-4057qib7 14900 49 the the DT cord-005453-4057qib7 14900 50 addition addition NN cord-005453-4057qib7 14900 51 of of IN cord-005453-4057qib7 14900 52 plerixaphor plerixaphor NNP cord-005453-4057qib7 14900 53 at at IN cord-005453-4057qib7 14900 54 a a DT cord-005453-4057qib7 14900 55 dose dose NN cord-005453-4057qib7 14900 56 of of IN cord-005453-4057qib7 14900 57 0.24 0.24 CD cord-005453-4057qib7 14900 58 μg μg NNP cord-005453-4057qib7 14900 59 / / SYM cord-005453-4057qib7 14900 60 kg kg NNP cord-005453-4057qib7 14900 61 ( ( -LRB- cord-005453-4057qib7 14900 62 9 9 CD cord-005453-4057qib7 14900 63 samples sample NNS cord-005453-4057qib7 14900 64 from from IN cord-005453-4057qib7 14900 65 9 9 CD cord-005453-4057qib7 14900 66 patients patient NNS cord-005453-4057qib7 14900 67 ) ) -RRB- cord-005453-4057qib7 14900 68 . . . cord-005453-4057qib7 14901 1 Immunophenotype immunophenotype NN cord-005453-4057qib7 14901 2 viability viability NN cord-005453-4057qib7 14901 3 of of IN cord-005453-4057qib7 14901 4 HSCs hscs NN cord-005453-4057qib7 14901 5 in in IN cord-005453-4057qib7 14901 6 autotransplants autotransplant NNS cord-005453-4057qib7 14901 7 after after IN cord-005453-4057qib7 14901 8 cryopreservation cryopreservation NN cord-005453-4057qib7 14901 9 were be VBD cord-005453-4057qib7 14901 10 determined determine VBN cord-005453-4057qib7 14901 11 by by IN cord-005453-4057qib7 14901 12 flow flow NN cord-005453-4057qib7 14901 13 cytometry cytometry NN cord-005453-4057qib7 14901 14 using use VBG cord-005453-4057qib7 14901 15 the the DT cord-005453-4057qib7 14901 16 ISHAGE ISHAGE NNP cord-005453-4057qib7 14901 17 protocol protocol NN cord-005453-4057qib7 14901 18 on on IN cord-005453-4057qib7 14901 19 a a DT cord-005453-4057qib7 14901 20 flow flow NN cord-005453-4057qib7 14901 21 cytometer cytometer NN cord-005453-4057qib7 14901 22 ( ( -LRB- cord-005453-4057qib7 14901 23 FACS FACS NNP cord-005453-4057qib7 14901 24 CantoII CantoII NNP cord-005453-4057qib7 14901 25 , , , cord-005453-4057qib7 14901 26 Becton Becton NNP cord-005453-4057qib7 14901 27 Dickinson Dickinson NNP cord-005453-4057qib7 14901 28 ) ) -RRB- cord-005453-4057qib7 14901 29 by by IN cord-005453-4057qib7 14901 30 expressing express VBG cord-005453-4057qib7 14901 31 surface surface NN cord-005453-4057qib7 14901 32 markers marker NNS cord-005453-4057qib7 14901 33 of of IN cord-005453-4057qib7 14901 34 antibodies antibody NNS cord-005453-4057qib7 14901 35 against against IN cord-005453-4057qib7 14901 36 CD34 CD34 NNP cord-005453-4057qib7 14901 37 , , , cord-005453-4057qib7 14901 38 CD45 CD45 NNP cord-005453-4057qib7 14901 39 , , , cord-005453-4057qib7 14901 40 CD90 CD90 NNP cord-005453-4057qib7 14901 41 , , , cord-005453-4057qib7 14901 42 CD38 CD38 NNP cord-005453-4057qib7 14901 43 and and CC cord-005453-4057qib7 14901 44 staining stain VBG cord-005453-4057qib7 14901 45 with with IN cord-005453-4057qib7 14901 46 7aminoactinomycin 7aminoactinomycin CD cord-005453-4057qib7 14901 47 ( ( -LRB- cord-005453-4057qib7 14901 48 7-AAD 7-aad CD cord-005453-4057qib7 14901 49 ) ) -RRB- cord-005453-4057qib7 14901 50 . . . cord-005453-4057qib7 14902 1 The the DT cord-005453-4057qib7 14902 2 colony colony NN cord-005453-4057qib7 14902 3 - - HYPH cord-005453-4057qib7 14902 4 forming form VBG cord-005453-4057qib7 14902 5 activity activity NN cord-005453-4057qib7 14902 6 of of IN cord-005453-4057qib7 14902 7 HSCs HSCs NNP cord-005453-4057qib7 14903 1 ( ( -LRB- cord-005453-4057qib7 14903 2 CFU CFU NNP cord-005453-4057qib7 14903 3 - - HYPH cord-005453-4057qib7 14903 4 CFU CFU NNP cord-005453-4057qib7 14903 5 - - HYPH cord-005453-4057qib7 14903 6 mix mix NN cord-005453-4057qib7 14903 7 , , , cord-005453-4057qib7 14903 8 CFU CFU NNP cord-005453-4057qib7 14903 9 - - HYPH cord-005453-4057qib7 14903 10 GM GM NNP cord-005453-4057qib7 14903 11 , , , cord-005453-4057qib7 14903 12 CFU CFU NNP cord-005453-4057qib7 14903 13 - - HYPH cord-005453-4057qib7 14903 14 G G NNP cord-005453-4057qib7 14903 15 , , , cord-005453-4057qib7 14903 16 CFU CFU NNP cord-005453-4057qib7 14903 17 - - HYPH cord-005453-4057qib7 14903 18 M M NNP cord-005453-4057qib7 14903 19 ) ) -RRB- cord-005453-4057qib7 14903 20 was be VBD cord-005453-4057qib7 14903 21 evaluated evaluate VBN cord-005453-4057qib7 14903 22 in in IN cord-005453-4057qib7 14903 23 methylcellulose methylcellulose NN cord-005453-4057qib7 14903 24 ( ( -LRB- cord-005453-4057qib7 14903 25 MethoCult MethoCult NNP cord-005453-4057qib7 14903 26 H4435 H4435 NNP cord-005453-4057qib7 14903 27 , , , cord-005453-4057qib7 14903 28 Stemcell Stemcell NNP cord-005453-4057qib7 14903 29 Technologies Technologies NNPS cord-005453-4057qib7 14903 30 , , , cord-005453-4057qib7 14903 31 Canada Canada NNP cord-005453-4057qib7 14903 32 ) ) -RRB- cord-005453-4057qib7 14903 33 for for IN cord-005453-4057qib7 14903 34 1x10 1x10 CD cord-005453-4057qib7 14903 35 5 5 CD cord-005453-4057qib7 14903 36 transplanted transplant VBN cord-005453-4057qib7 14903 37 cells cell NNS cord-005453-4057qib7 14903 38 for for IN cord-005453-4057qib7 14903 39 14 14 CD cord-005453-4057qib7 14903 40 days day NNS cord-005453-4057qib7 14903 41 . . . cord-005453-4057qib7 14904 1 Results result NNS cord-005453-4057qib7 14904 2 : : : cord-005453-4057qib7 14905 1 The the DT cord-005453-4057qib7 14905 2 viability viability NN cord-005453-4057qib7 14905 3 of of IN cord-005453-4057qib7 14905 4 HSCs hscs NN cord-005453-4057qib7 14905 5 in in IN cord-005453-4057qib7 14905 6 autografts autografts NNP cord-005453-4057qib7 14906 1 ( ( -LRB- cord-005453-4057qib7 14906 2 CD45 CD45 NNP cord-005453-4057qib7 14907 1 + + CC cord-005453-4057qib7 14907 2 / / SYM cord-005453-4057qib7 14907 3 CD34 CD34 NNP cord-005453-4057qib7 14907 4 + + CC cord-005453-4057qib7 14907 5 / / SYM cord-005453-4057qib7 14907 6 7ADD- 7add- CD cord-005453-4057qib7 14907 7 ) ) -RRB- cord-005453-4057qib7 14908 1 after after IN cord-005453-4057qib7 14908 2 cryopreservation cryopreservation NN cord-005453-4057qib7 14908 3 in in IN cord-005453-4057qib7 14908 4 both both DT cord-005453-4057qib7 14908 5 groups group NNS cord-005453-4057qib7 14908 6 was be VBD cord-005453-4057qib7 14908 7 98 98 CD cord-005453-4057qib7 14908 8 ± ± CD cord-005453-4057qib7 14908 9 0.7 0.7 CD cord-005453-4057qib7 14908 10 % % NN cord-005453-4057qib7 14908 11 . . . cord-005453-4057qib7 14909 1 In in IN cord-005453-4057qib7 14909 2 the the DT cord-005453-4057qib7 14909 3 group group NN cord-005453-4057qib7 14909 4 of of IN cord-005453-4057qib7 14909 5 samples sample NNS cord-005453-4057qib7 14909 6 using use VBG cord-005453-4057qib7 14909 7 plerixaphor plerixaphor NNP cord-005453-4057qib7 14909 8 , , , cord-005453-4057qib7 14909 9 a a DT cord-005453-4057qib7 14909 10 higher high JJR cord-005453-4057qib7 14909 11 content content NN cord-005453-4057qib7 14909 12 of of IN cord-005453-4057qib7 14909 13 primitive primitive JJ cord-005453-4057qib7 14909 14 hemopoiesis hemopoiesis NN cord-005453-4057qib7 14909 15 precursors precursor NNS cord-005453-4057qib7 14909 16 ( ( -LRB- cord-005453-4057qib7 14909 17 primitive primitive JJ cord-005453-4057qib7 14909 18 cells cell NNS cord-005453-4057qib7 14909 19 ) ) -RRB- cord-005453-4057qib7 14909 20 ( ( -LRB- cord-005453-4057qib7 14909 21 CD34 CD34 NNP cord-005453-4057qib7 14909 22 + + SYM cord-005453-4057qib7 14909 23 CD90 CD90 NNP cord-005453-4057qib7 14909 24 + + CC cord-005453-4057qib7 14909 25 CD38- cd38- NN cord-005453-4057qib7 14909 26 ) ) -RRB- cord-005453-4057qib7 14909 27 was be VBD cord-005453-4057qib7 14909 28 detected detect VBN cord-005453-4057qib7 14909 29 compared compare VBN cord-005453-4057qib7 14909 30 with with IN cord-005453-4057qib7 14909 31 the the DT cord-005453-4057qib7 14909 32 control control NN cord-005453-4057qib7 14909 33 group group NN cord-005453-4057qib7 14909 34 ( ( -LRB- cord-005453-4057qib7 14909 35 29.2 29.2 CD cord-005453-4057qib7 14909 36 ± ± CD cord-005453-4057qib7 14909 37 2.7 2.7 CD cord-005453-4057qib7 14909 38 % % NN cord-005453-4057qib7 14909 39 and and CC cord-005453-4057qib7 14909 40 13.2 13.2 CD cord-005453-4057qib7 14909 41 ± ± CD cord-005453-4057qib7 14909 42 12 12 CD cord-005453-4057qib7 14909 43 % % NN cord-005453-4057qib7 14909 44 , , , cord-005453-4057qib7 14909 45 respectively respectively RB cord-005453-4057qib7 14909 46 ) ) -RRB- cord-005453-4057qib7 14909 47 . . . cord-005453-4057qib7 14910 1 The the DT cord-005453-4057qib7 14910 2 CFU CFU NNP cord-005453-4057qib7 14910 3 count count NN cord-005453-4057qib7 14910 4 ( ( -LRB- cord-005453-4057qib7 14910 5 CFU CFU NNP cord-005453-4057qib7 14910 6 - - HYPH cord-005453-4057qib7 14910 7 CFU CFU NNP cord-005453-4057qib7 14910 8 - - HYPH cord-005453-4057qib7 14910 9 mix mix NN cord-005453-4057qib7 14910 10 , , , cord-005453-4057qib7 14910 11 CFU CFU NNP cord-005453-4057qib7 14910 12 - - HYPH cord-005453-4057qib7 14910 13 GM GM NNP cord-005453-4057qib7 14910 14 , , , cord-005453-4057qib7 14910 15 CFU CFU NNP cord-005453-4057qib7 14910 16 - - HYPH cord-005453-4057qib7 14910 17 G G NNP cord-005453-4057qib7 14910 18 , , , cord-005453-4057qib7 14910 19 CFU CFU NNP cord-005453-4057qib7 14910 20 - - HYPH cord-005453-4057qib7 14910 21 M M NNP cord-005453-4057qib7 14910 22 ) ) -RRB- cord-005453-4057qib7 14910 23 in in IN cord-005453-4057qib7 14910 24 the the DT cord-005453-4057qib7 14910 25 plerixafor plerixafor NN cord-005453-4057qib7 14910 26 group group NN cord-005453-4057qib7 14910 27 was be VBD cord-005453-4057qib7 14910 28 100 100 CD cord-005453-4057qib7 14910 29 ± ± CD cord-005453-4057qib7 14910 30 2.5 2.5 CD cord-005453-4057qib7 14910 31 per per IN cord-005453-4057qib7 14910 32 1x105 1x105 CD cord-005453-4057qib7 14910 33 explanted explante VBN cord-005453-4057qib7 14910 34 cells cell NNS cord-005453-4057qib7 14910 35 , , , cord-005453-4057qib7 14910 36 in in IN cord-005453-4057qib7 14910 37 the the DT cord-005453-4057qib7 14910 38 control control NN cord-005453-4057qib7 14910 39 group group NN cord-005453-4057qib7 14910 40 -70 -70 NN cord-005453-4057qib7 14910 41 ± ± NNP cord-005453-4057qib7 14910 42 1.8 1.8 CD cord-005453-4057qib7 14910 43 ( ( -LRB- cord-005453-4057qib7 14910 44 Figure Figure NNP cord-005453-4057qib7 14910 45 1A 1a NN cord-005453-4057qib7 14910 46 - - HYPH cord-005453-4057qib7 14910 47 D D NNP cord-005453-4057qib7 14910 48 ) ) -RRB- cord-005453-4057qib7 14910 49 . . . cord-005453-4057qib7 14911 1 Conclusions conclusion NNS cord-005453-4057qib7 14911 2 : : : cord-005453-4057qib7 14912 1 The the DT cord-005453-4057qib7 14912 2 use use NN cord-005453-4057qib7 14912 3 of of IN cord-005453-4057qib7 14912 4 plerixafor plerixafor NN cord-005453-4057qib7 14912 5 against against IN cord-005453-4057qib7 14912 6 the the DT cord-005453-4057qib7 14912 7 background background NN cord-005453-4057qib7 14912 8 of of IN cord-005453-4057qib7 14912 9 standard standard JJ cord-005453-4057qib7 14912 10 protocols protocol NNS cord-005453-4057qib7 14912 11 for for IN cord-005453-4057qib7 14912 12 the the DT cord-005453-4057qib7 14912 13 mobilization mobilization NN cord-005453-4057qib7 14912 14 of of IN cord-005453-4057qib7 14912 15 HSCs HSCs NNP cord-005453-4057qib7 14912 16 allows allow VBZ cord-005453-4057qib7 14912 17 to to TO cord-005453-4057qib7 14912 18 obtain obtain VB cord-005453-4057qib7 14912 19 high high JJ cord-005453-4057qib7 14912 20 - - HYPH cord-005453-4057qib7 14912 21 quality quality NN cord-005453-4057qib7 14912 22 graft graft NN cord-005453-4057qib7 14912 23 with with IN cord-005453-4057qib7 14912 24 a a DT cord-005453-4057qib7 14912 25 higher high JJR cord-005453-4057qib7 14912 26 content content NN cord-005453-4057qib7 14912 27 of of IN cord-005453-4057qib7 14912 28 primitive primitive JJ cord-005453-4057qib7 14912 29 cells cell NNS cord-005453-4057qib7 14912 30 and and CC cord-005453-4057qib7 14912 31 proliferative proliferative JJ cord-005453-4057qib7 14912 32 activity activity NN cord-005453-4057qib7 14912 33 . . . cord-005453-4057qib7 14913 1 Disclosure disclosure NN cord-005453-4057qib7 14913 2 : : : cord-005453-4057qib7 14913 3 no no DT cord-005453-4057qib7 14913 4 conflict conflict NN cord-005453-4057qib7 14913 5 of of IN cord-005453-4057qib7 14913 6 interest interest NN cord-005453-4057qib7 14913 7 . . . cord-005453-4057qib7 14914 1 Nothing nothing NN cord-005453-4057qib7 14914 2 to to TO cord-005453-4057qib7 14914 3 declare declare VB cord-005453-4057qib7 14914 4 . . . cord-005453-4057qib7 14915 1 Comparison comparison NN cord-005453-4057qib7 14915 2 of of IN cord-005453-4057qib7 14915 3 effectiveness effectiveness NN cord-005453-4057qib7 14915 4 of of IN cord-005453-4057qib7 14915 5 plerixafor plerixafor NN cord-005453-4057qib7 14915 6 plus plus CC cord-005453-4057qib7 14915 7 G G NNP cord-005453-4057qib7 14915 8 - - HYPH cord-005453-4057qib7 14915 9 CSF CSF NNP cord-005453-4057qib7 14915 10 in in IN cord-005453-4057qib7 14915 11 poor poor JJ cord-005453-4057qib7 14915 12 and and CC cord-005453-4057qib7 14915 13 very very RB cord-005453-4057qib7 14915 14 poor poor JJ cord-005453-4057qib7 14915 15 - - HYPH cord-005453-4057qib7 14915 16 movilizers movilizer NNS cord-005453-4057qib7 14915 17 : : : cord-005453-4057qib7 14915 18 Efficacy efficacy NN cord-005453-4057qib7 14915 19 of of IN cord-005453-4057qib7 14915 20 the the DT cord-005453-4057qib7 14915 21 combination combination NN cord-005453-4057qib7 14915 22 of of IN cord-005453-4057qib7 14915 23 plerixafor plerixafor NN cord-005453-4057qib7 14915 24 and and CC cord-005453-4057qib7 14915 25 G G NNP cord-005453-4057qib7 14915 26 - - HYPH cord-005453-4057qib7 14915 27 CSF CSF NNP cord-005453-4057qib7 14915 28 in in IN cord-005453-4057qib7 14915 29 poor poor JJ cord-005453-4057qib7 14915 30 - - HYPH cord-005453-4057qib7 14915 31 movilizer movilizer NN cord-005453-4057qib7 14915 32 Background background NN cord-005453-4057qib7 14915 33 : : : cord-005453-4057qib7 14916 1 Healthy healthy JJ cord-005453-4057qib7 14916 2 donors donor NNS cord-005453-4057qib7 14916 3 ocassionally ocassionally RB cord-005453-4057qib7 14916 4 show show VBP cord-005453-4057qib7 14916 5 a a DT cord-005453-4057qib7 14916 6 poor poor JJ cord-005453-4057qib7 14916 7 response response NN cord-005453-4057qib7 14916 8 to to IN cord-005453-4057qib7 14916 9 mobilization mobilization NN cord-005453-4057qib7 14916 10 agents agent NNS cord-005453-4057qib7 14916 11 . . . cord-005453-4057qib7 14917 1 Plerixafor+G Plerixafor+G NNP cord-005453-4057qib7 14917 2 - - HYPH cord-005453-4057qib7 14917 3 CSF CSF NNP cord-005453-4057qib7 14917 4 can can MD cord-005453-4057qib7 14917 5 be be VB cord-005453-4057qib7 14917 6 a a DT cord-005453-4057qib7 14917 7 salvage salvage NN cord-005453-4057qib7 14917 8 strategy strategy NN cord-005453-4057qib7 14917 9 in in IN cord-005453-4057qib7 14917 10 poor poor JJ cord-005453-4057qib7 14917 11 mobilizers mobilizer NNS cord-005453-4057qib7 14917 12 . . . cord-005453-4057qib7 14918 1 Some some DT cord-005453-4057qib7 14918 2 series series NN cord-005453-4057qib7 14918 3 describe describe VBP cord-005453-4057qib7 14918 4 the the DT cord-005453-4057qib7 14918 5 use use NN cord-005453-4057qib7 14918 6 of of IN cord-005453-4057qib7 14918 7 plerixafor plerixafor NN cord-005453-4057qib7 14918 8 to to TO cord-005453-4057qib7 14918 9 collect collect VB cord-005453-4057qib7 14918 10 greater great JJR cord-005453-4057qib7 14918 11 doses dose NNS cord-005453-4057qib7 14918 12 of of IN cord-005453-4057qib7 14918 13 CD34 CD34 NNP cord-005453-4057qib7 14918 14 + + CC cord-005453-4057qib7 14918 15 cells cell NNS cord-005453-4057qib7 14918 16 in in IN cord-005453-4057qib7 14918 17 hematopoietic hematopoietic JJ cord-005453-4057qib7 14918 18 stem stem NN cord-005453-4057qib7 14918 19 cell cell NN cord-005453-4057qib7 14918 20 transplantation transplantation NN cord-005453-4057qib7 14918 21 ( ( -LRB- cord-005453-4057qib7 14918 22 HSCT HSCT NNP cord-005453-4057qib7 14918 23 ) ) -RRB- cord-005453-4057qib7 14918 24 with with IN cord-005453-4057qib7 14918 25 Tcell Tcell NNP cord-005453-4057qib7 14918 26 depletion depletion NN cord-005453-4057qib7 14918 27 . . . cord-005453-4057qib7 14919 1 Plerixafor Plerixafor NNP cord-005453-4057qib7 14919 2 use use VB cord-005453-4057qib7 14919 3 in in IN cord-005453-4057qib7 14919 4 the the DT cord-005453-4057qib7 14919 5 mobilization mobilization NN cord-005453-4057qib7 14919 6 protocol protocol NN cord-005453-4057qib7 14919 7 could could MD cord-005453-4057qib7 14919 8 help help VB cord-005453-4057qib7 14919 9 collecting collect VBG cord-005453-4057qib7 14919 10 higher high JJR cord-005453-4057qib7 14919 11 CD34 CD34 NNP cord-005453-4057qib7 14919 12 + + CC cord-005453-4057qib7 14919 13 dose dose NN cord-005453-4057qib7 14919 14 in in IN cord-005453-4057qib7 14919 15 indirect indirect JJ cord-005453-4057qib7 14919 16 T t NN cord-005453-4057qib7 14919 17 - - HYPH cord-005453-4057qib7 14919 18 cell cell NN cord-005453-4057qib7 14919 19 depletion depletion NN cord-005453-4057qib7 14919 20 ( ( -LRB- cord-005453-4057qib7 14919 21 CD34 CD34 NNP cord-005453-4057qib7 14919 22 + + CC cord-005453-4057qib7 14919 23 selection selection NN cord-005453-4057qib7 14919 24 ) ) -RRB- cord-005453-4057qib7 14919 25 for for IN cord-005453-4057qib7 14919 26 ex ex NN cord-005453-4057qib7 14919 27 - - NN cord-005453-4057qib7 14919 28 vivo vivo JJ cord-005453-4057qib7 14919 29 manipulated manipulate VBN cord-005453-4057qib7 14919 30 haploidentical haploidentical JJ cord-005453-4057qib7 14919 31 transplantation transplantation NN cord-005453-4057qib7 14919 32 , , , cord-005453-4057qib7 14919 33 with with IN cord-005453-4057qib7 14919 34 less less JJR cord-005453-4057qib7 14919 35 number number NN cord-005453-4057qib7 14919 36 of of IN cord-005453-4057qib7 14919 37 apheresis apheresis NN cord-005453-4057qib7 14919 38 and and CC cord-005453-4057qib7 14919 39 a a DT cord-005453-4057qib7 14919 40 rapid rapid JJ cord-005453-4057qib7 14919 41 engraftment engraftment NN cord-005453-4057qib7 14919 42 . . . cord-005453-4057qib7 14920 1 Methods method NNS cord-005453-4057qib7 14920 2 : : : cord-005453-4057qib7 14920 3 Data datum NNS cord-005453-4057qib7 14920 4 of of IN cord-005453-4057qib7 14920 5 fourteen fourteen CD cord-005453-4057qib7 14920 6 healthy healthy JJ cord-005453-4057qib7 14920 7 peripheral peripheral JJ cord-005453-4057qib7 14920 8 - - HYPH cord-005453-4057qib7 14920 9 blood blood NN cord-005453-4057qib7 14920 10 donors donor NNS cord-005453-4057qib7 14920 11 was be VBD cord-005453-4057qib7 14920 12 retrospectively retrospectively RB cord-005453-4057qib7 14920 13 collected collect VBN cord-005453-4057qib7 14920 14 . . . cord-005453-4057qib7 14921 1 They -PRON- PRP cord-005453-4057qib7 14921 2 received receive VBD cord-005453-4057qib7 14921 3 4 4 CD cord-005453-4057qib7 14921 4 days day NNS cord-005453-4057qib7 14921 5 10 10 CD cord-005453-4057qib7 14921 6 mcg mcg NN cord-005453-4057qib7 14921 7 / / SYM cord-005453-4057qib7 14921 8 Kg Kg NNP cord-005453-4057qib7 14921 9 / / SYM cord-005453-4057qib7 14921 10 day day NN cord-005453-4057qib7 14921 11 G G NNP cord-005453-4057qib7 14921 12 - - HYPH cord-005453-4057qib7 14921 13 CSF CSF NNP cord-005453-4057qib7 14921 14 and and CC cord-005453-4057qib7 14921 15 0,24 0,24 CD cord-005453-4057qib7 14921 16 mg mg NNP cord-005453-4057qib7 14921 17 / / SYM cord-005453-4057qib7 14921 18 Kg Kg NNP cord-005453-4057qib7 14921 19 / / SYM cord-005453-4057qib7 14921 20 day day NN cord-005453-4057qib7 14921 21 Plerixafor Plerixafor NNP cord-005453-4057qib7 14921 22 on on IN cord-005453-4057qib7 14921 23 4º 4º CD cord-005453-4057qib7 14921 24 day day NN cord-005453-4057qib7 14921 25 as as IN cord-005453-4057qib7 14921 26 mobilization mobilization NN cord-005453-4057qib7 14921 27 treatment treatment NN cord-005453-4057qib7 14921 28 . . . cord-005453-4057qib7 14922 1 Fourteen fourteen CD cord-005453-4057qib7 14922 2 pediatric pediatric JJ cord-005453-4057qib7 14922 3 patients patient NNS cord-005453-4057qib7 14922 4 ( ( -LRB- cord-005453-4057qib7 14922 5 median median JJ cord-005453-4057qib7 14922 6 age age NN cord-005453-4057qib7 14922 7 13 13 CD cord-005453-4057qib7 14922 8 years year NNS cord-005453-4057qib7 14922 9 , , , cord-005453-4057qib7 14922 10 range range VBP cord-005453-4057qib7 14922 11 8 8 CD cord-005453-4057qib7 14922 12 - - SYM cord-005453-4057qib7 14922 13 15 15 CD cord-005453-4057qib7 14922 14 ) ) -RRB- cord-005453-4057qib7 14922 15 diagnosed diagnose VBN cord-005453-4057qib7 14922 16 with with IN cord-005453-4057qib7 14922 17 malignant malignant JJ cord-005453-4057qib7 14922 18 and and CC cord-005453-4057qib7 14922 19 no no DT cord-005453-4057qib7 14922 20 malignant malignant JJ cord-005453-4057qib7 14922 21 hematological hematological JJ cord-005453-4057qib7 14922 22 diseases disease NNS cord-005453-4057qib7 14922 23 received receive VBD cord-005453-4057qib7 14922 24 haploidentical haploidentical JJ cord-005453-4057qib7 14922 25 HSCT HSCT NNP cord-005453-4057qib7 14922 26 with with IN cord-005453-4057qib7 14922 27 CD34 CD34 NNP cord-005453-4057qib7 14922 28 + + CC cord-005453-4057qib7 14922 29 selection selection NN cord-005453-4057qib7 14922 30 and and CC cord-005453-4057qib7 14922 31 CD45RA+ CD45RA+ NNP cord-005453-4057qib7 14922 32 depletion depletion NN cord-005453-4057qib7 14922 33 between between IN cord-005453-4057qib7 14922 34 February February NNP cord-005453-4057qib7 14922 35 2015 2015 CD cord-005453-4057qib7 14922 36 and and CC cord-005453-4057qib7 14922 37 July July NNP cord-005453-4057qib7 14922 38 2017 2017 CD cord-005453-4057qib7 14922 39 . . . cord-005453-4057qib7 14923 1 Results result NNS cord-005453-4057qib7 14923 2 : : : cord-005453-4057qib7 14924 1 One one CD cord-005453-4057qib7 14924 2 leukoapheresis leukoapheresis NN cord-005453-4057qib7 14924 3 procedure procedure NN cord-005453-4057qib7 14924 4 was be VBD cord-005453-4057qib7 14924 5 performed perform VBN cord-005453-4057qib7 14924 6 in in IN cord-005453-4057qib7 14924 7 all all DT cord-005453-4057qib7 14924 8 cases case NNS cord-005453-4057qib7 14924 9 . . . cord-005453-4057qib7 14925 1 Median median JJ cord-005453-4057qib7 14925 2 processed process VBN cord-005453-4057qib7 14925 3 volume volume NN cord-005453-4057qib7 14925 4 was be VBD cord-005453-4057qib7 14925 5 11 11 CD cord-005453-4057qib7 14925 6 liters liter NNS cord-005453-4057qib7 14925 7 ( ( -LRB- cord-005453-4057qib7 14925 8 range range NNP cord-005453-4057qib7 14925 9 6 6 CD cord-005453-4057qib7 14925 10 - - SYM cord-005453-4057qib7 14925 11 14 14 CD cord-005453-4057qib7 14925 12 ) ) -RRB- cord-005453-4057qib7 14925 13 . . . cord-005453-4057qib7 14926 1 Median median NN cord-005453-4057qib7 14926 2 of of IN cord-005453-4057qib7 14926 3 CD34 CD34 NNP cord-005453-4057qib7 14926 4 + + CC cord-005453-4057qib7 14926 5 cells cell NNS cord-005453-4057qib7 14926 6 obtained obtain VBN cord-005453-4057qib7 14926 7 was be VBD cord-005453-4057qib7 14926 8 13,73x10 13,73x10 CD cord-005453-4057qib7 14926 9 6 6 CD cord-005453-4057qib7 14927 1 /Kg /Kg . cord-005453-4057qib7 14928 1 ( ( -LRB- cord-005453-4057qib7 14928 2 range range NNP cord-005453-4057qib7 14928 3 7,8 7,8 NNP cord-005453-4057qib7 14928 4 - - HYPH cord-005453-4057qib7 14928 5 26,47 26,47 CD cord-005453-4057qib7 14928 6 ) ) -RRB- cord-005453-4057qib7 14928 7 . . . cord-005453-4057qib7 14929 1 After after IN cord-005453-4057qib7 14929 2 positive positive JJ cord-005453-4057qib7 14929 3 selection selection NN cord-005453-4057qib7 14929 4 , , , cord-005453-4057qib7 14929 5 > > XX cord-005453-4057qib7 14930 1 4x10 4x10 CD cord-005453-4057qib7 14930 2 6 6 CD cord-005453-4057qib7 14931 1 /Kg /Kg . cord-005453-4057qib7 14932 1 CD34 CD34 NNP cord-005453-4057qib7 14932 2 + + CC cord-005453-4057qib7 14932 3 cells cell NNS cord-005453-4057qib7 14932 4 were be VBD cord-005453-4057qib7 14932 5 infused infuse VBN cord-005453-4057qib7 14932 6 in in IN cord-005453-4057qib7 14932 7 all all DT cord-005453-4057qib7 14932 8 cases case NNS cord-005453-4057qib7 14932 9 ( ( -LRB- cord-005453-4057qib7 14932 10 Figure figure NN cord-005453-4057qib7 14932 11 1 1 CD cord-005453-4057qib7 14932 12 ) ) -RRB- cord-005453-4057qib7 14932 13 . . . cord-005453-4057qib7 14933 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 14933 2 engraftment engraftment NN cord-005453-4057qib7 14933 3 was be VBD cord-005453-4057qib7 14933 4 achieved achieve VBN cord-005453-4057qib7 14933 5 after after IN cord-005453-4057qib7 14933 6 a a DT cord-005453-4057qib7 14933 7 median median NN cord-005453-4057qib7 14933 8 of of IN cord-005453-4057qib7 14933 9 15 15 CD cord-005453-4057qib7 14933 10 days day NNS cord-005453-4057qib7 14933 11 ( ( -LRB- cord-005453-4057qib7 14933 12 range range VBP cord-005453-4057qib7 14933 13 10 10 CD cord-005453-4057qib7 14933 14 - - SYM cord-005453-4057qib7 14933 15 17 17 CD cord-005453-4057qib7 14933 16 ) ) -RRB- cord-005453-4057qib7 14933 17 . . . cord-005453-4057qib7 14934 1 Few few JJ cord-005453-4057qib7 14934 2 donors donor NNS cord-005453-4057qib7 14934 3 presented present VBD cord-005453-4057qib7 14934 4 only only RB cord-005453-4057qib7 14934 5 Plerixafor Plerixafor NNP cord-005453-4057qib7 14934 6 mild mild JJ cord-005453-4057qib7 14934 7 secondary secondary JJ cord-005453-4057qib7 14934 8 effects effect NNS cord-005453-4057qib7 14934 9 . . . cord-005453-4057qib7 14935 1 Conclusions conclusion NNS cord-005453-4057qib7 14935 2 : : : cord-005453-4057qib7 14936 1 Our -PRON- PRP$ cord-005453-4057qib7 14936 2 experience experience NN cord-005453-4057qib7 14936 3 showed show VBD cord-005453-4057qib7 14936 4 that that IN cord-005453-4057qib7 14936 5 a a DT cord-005453-4057qib7 14936 6 mobilization mobilization NN cord-005453-4057qib7 14936 7 protocol protocol NN cord-005453-4057qib7 14936 8 using use VBG cord-005453-4057qib7 14936 9 G G NNP cord-005453-4057qib7 14936 10 - - HYPH cord-005453-4057qib7 14936 11 CSF CSF NNP cord-005453-4057qib7 14936 12 and and CC cord-005453-4057qib7 14936 13 standard standard JJ cord-005453-4057qib7 14936 14 dose dose NN cord-005453-4057qib7 14936 15 of of IN cord-005453-4057qib7 14936 16 Plerixafor Plerixafor NNP cord-005453-4057qib7 14936 17 ( ( -LRB- cord-005453-4057qib7 14936 18 compasive compasive NNP cord-005453-4057qib7 14936 19 use use NN cord-005453-4057qib7 14936 20 ) ) -RRB- cord-005453-4057qib7 14936 21 is be VBZ cord-005453-4057qib7 14936 22 a a DT cord-005453-4057qib7 14936 23 safe safe JJ cord-005453-4057qib7 14936 24 strategy strategy NN cord-005453-4057qib7 14936 25 that that WDT cord-005453-4057qib7 14936 26 allows allow VBZ cord-005453-4057qib7 14936 27 collecting collect VBG cord-005453-4057qib7 14936 28 great great JJ cord-005453-4057qib7 14936 29 CD34 CD34 NNP cord-005453-4057qib7 14936 30 + + CC cord-005453-4057qib7 14936 31 dose dose NN cord-005453-4057qib7 14936 32 in in IN cord-005453-4057qib7 14936 33 one one CD cord-005453-4057qib7 14936 34 apheresis apheresis NN cord-005453-4057qib7 14936 35 procedure procedure NN cord-005453-4057qib7 14936 36 . . . cord-005453-4057qib7 14937 1 This this DT cord-005453-4057qib7 14937 2 could could MD cord-005453-4057qib7 14937 3 be be VB cord-005453-4057qib7 14937 4 useful useful JJ cord-005453-4057qib7 14937 5 for for IN cord-005453-4057qib7 14937 6 haploidentical haploidentical JJ cord-005453-4057qib7 14937 7 transplantation transplantation NN cord-005453-4057qib7 14937 8 with with IN cord-005453-4057qib7 14937 9 ex ex JJ cord-005453-4057qib7 14937 10 - - JJ cord-005453-4057qib7 14937 11 vivo vivo JJ cord-005453-4057qib7 14937 12 T t NN cord-005453-4057qib7 14937 13 depletion depletion NN cord-005453-4057qib7 14937 14 , , , cord-005453-4057qib7 14937 15 especially especially RB cord-005453-4057qib7 14937 16 if if IN cord-005453-4057qib7 14937 17 there´s there´s NNP cord-005453-4057qib7 14937 18 a a DT cord-005453-4057qib7 14937 19 weight weight NN cord-005453-4057qib7 14937 20 disproportion disproportion NN cord-005453-4057qib7 14937 21 between between IN cord-005453-4057qib7 14937 22 donor donor NN cord-005453-4057qib7 14937 23 and and CC cord-005453-4057qib7 14937 24 patient patient NN cord-005453-4057qib7 14937 25 . . . cord-005453-4057qib7 14938 1 Background background NN cord-005453-4057qib7 14938 2 : : : cord-005453-4057qib7 14939 1 Mesenchymal Mesenchymal NNS cord-005453-4057qib7 14939 2 stem stem VBP cord-005453-4057qib7 14939 3 cells cell NNS cord-005453-4057qib7 14939 4 ( ( -LRB- cord-005453-4057qib7 14939 5 MSCs msc NNS cord-005453-4057qib7 14939 6 ) ) -RRB- cord-005453-4057qib7 14939 7 are be VBP cord-005453-4057qib7 14939 8 selfrenewing selfrenewe VBG cord-005453-4057qib7 14939 9 multipotent multipotent JJ cord-005453-4057qib7 14939 10 progenitor progenitor NN cord-005453-4057qib7 14939 11 cells cell NNS cord-005453-4057qib7 14939 12 with with IN cord-005453-4057qib7 14939 13 wide wide JJ cord-005453-4057qib7 14939 14 differentiation differentiation NN cord-005453-4057qib7 14939 15 potential potential NN cord-005453-4057qib7 14939 16 . . . cord-005453-4057qib7 14940 1 Their -PRON- PRP$ cord-005453-4057qib7 14940 2 ease ease NN cord-005453-4057qib7 14940 3 of of IN cord-005453-4057qib7 14940 4 isolation isolation NN cord-005453-4057qib7 14940 5 and and CC cord-005453-4057qib7 14940 6 expansion expansion NN cord-005453-4057qib7 14940 7 in in IN cord-005453-4057qib7 14940 8 vitro vitro FW cord-005453-4057qib7 14940 9 as as RB cord-005453-4057qib7 14940 10 well well RB cord-005453-4057qib7 14940 11 as as IN cord-005453-4057qib7 14940 12 their -PRON- PRP$ cord-005453-4057qib7 14940 13 unique unique JJ cord-005453-4057qib7 14940 14 regenerative regenerative JJ cord-005453-4057qib7 14940 15 therapeutic therapeutic JJ cord-005453-4057qib7 14940 16 properties property NNS cord-005453-4057qib7 14940 17 suggest suggest VBP cord-005453-4057qib7 14940 18 the the DT cord-005453-4057qib7 14940 19 use use NN cord-005453-4057qib7 14940 20 of of IN cord-005453-4057qib7 14940 21 MSC MSC NNP cord-005453-4057qib7 14940 22 as as IN cord-005453-4057qib7 14940 23 an an DT cord-005453-4057qib7 14940 24 approach approach NN cord-005453-4057qib7 14940 25 for for IN cord-005453-4057qib7 14940 26 treating treat VBG cord-005453-4057qib7 14940 27 several several JJ cord-005453-4057qib7 14940 28 disorders disorder NNS cord-005453-4057qib7 14940 29 . . . cord-005453-4057qib7 14941 1 Extra extra JJ cord-005453-4057qib7 14941 2 - - JJ cord-005453-4057qib7 14941 3 embryonic embryonic JJ cord-005453-4057qib7 14941 4 tissues tissue NNS cord-005453-4057qib7 14941 5 as as IN cord-005453-4057qib7 14941 6 placenta placenta NN cord-005453-4057qib7 14941 7 have have VBP cord-005453-4057qib7 14941 8 been be VBN cord-005453-4057qib7 14941 9 proposed propose VBN cord-005453-4057qib7 14941 10 as as IN cord-005453-4057qib7 14941 11 potential potential JJ cord-005453-4057qib7 14941 12 sources source NNS cord-005453-4057qib7 14941 13 of of IN cord-005453-4057qib7 14941 14 MSCs msc NNS cord-005453-4057qib7 14941 15 due due IN cord-005453-4057qib7 14941 16 to to IN cord-005453-4057qib7 14941 17 the the DT cord-005453-4057qib7 14941 18 absence absence NN cord-005453-4057qib7 14941 19 of of IN cord-005453-4057qib7 14941 20 ethical ethical JJ cord-005453-4057qib7 14941 21 problems problem NNS cord-005453-4057qib7 14941 22 neither neither CC cord-005453-4057qib7 14941 23 risks risk NNS cord-005453-4057qib7 14941 24 for for IN cord-005453-4057qib7 14941 25 the the DT cord-005453-4057qib7 14941 26 patients patient NNS cord-005453-4057qib7 14941 27 . . . cord-005453-4057qib7 14942 1 Furthermore furthermore RB cord-005453-4057qib7 14942 2 , , , cord-005453-4057qib7 14942 3 only only RB cord-005453-4057qib7 14942 4 protocols protocol NNS cord-005453-4057qib7 14942 5 using use VBG cord-005453-4057qib7 14942 6 fresh fresh JJ cord-005453-4057qib7 14942 7 placental placental NN cord-005453-4057qib7 14942 8 tissue tissue NN cord-005453-4057qib7 14942 9 have have VBP cord-005453-4057qib7 14942 10 been be VBN cord-005453-4057qib7 14942 11 described describe VBN cord-005453-4057qib7 14942 12 so so RB cord-005453-4057qib7 14942 13 far far RB cord-005453-4057qib7 14942 14 . . . cord-005453-4057qib7 14943 1 A a DT cord-005453-4057qib7 14943 2 protocol protocol NN cord-005453-4057qib7 14943 3 for for IN cord-005453-4057qib7 14943 4 isolating isolate VBG cord-005453-4057qib7 14943 5 MSCs msc NNS cord-005453-4057qib7 14943 6 from from IN cord-005453-4057qib7 14943 7 delayed delay VBN cord-005453-4057qib7 14943 8 - - HYPH cord-005453-4057qib7 14943 9 manipulated manipulate VBN cord-005453-4057qib7 14943 10 tissue tissue NN cord-005453-4057qib7 14943 11 was be VBD cord-005453-4057qib7 14943 12 designed design VBN cord-005453-4057qib7 14943 13 and and CC cord-005453-4057qib7 14943 14 tested test VBN cord-005453-4057qib7 14943 15 in in IN cord-005453-4057qib7 14943 16 order order NN cord-005453-4057qib7 14943 17 to to TO cord-005453-4057qib7 14943 18 optimize optimize VB cord-005453-4057qib7 14943 19 the the DT cord-005453-4057qib7 14943 20 use use NN cord-005453-4057qib7 14943 21 of of IN cord-005453-4057qib7 14943 22 placental placental NN cord-005453-4057qib7 14943 23 MSCs msc NNS cord-005453-4057qib7 14943 24 ( ( -LRB- cord-005453-4057qib7 14943 25 MSCs mscs NN cord-005453-4057qib7 14943 26 - - HYPH cord-005453-4057qib7 14943 27 P p NN cord-005453-4057qib7 14943 28 ) ) -RRB- cord-005453-4057qib7 14943 29 in in IN cord-005453-4057qib7 14943 30 an an DT cord-005453-4057qib7 14943 31 advanced advanced JJ cord-005453-4057qib7 14943 32 therapies therapy NNS cord-005453-4057qib7 14943 33 context context NN cord-005453-4057qib7 14943 34 . . . cord-005453-4057qib7 14944 1 Methods method NNS cord-005453-4057qib7 14944 2 : : : cord-005453-4057qib7 14944 3 Full full JJ cord-005453-4057qib7 14944 4 term term NN cord-005453-4057qib7 14944 5 placentas placenta NNS cord-005453-4057qib7 14944 6 ( ( -LRB- cord-005453-4057qib7 14944 7 n=10 n=10 NNP cord-005453-4057qib7 14944 8 ) ) -RRB- cord-005453-4057qib7 14944 9 were be VBD cord-005453-4057qib7 14944 10 obtained obtain VBN cord-005453-4057qib7 14944 11 from from IN cord-005453-4057qib7 14944 12 healthy healthy JJ cord-005453-4057qib7 14944 13 mothers mother NNS cord-005453-4057qib7 14944 14 in in IN cord-005453-4057qib7 14944 15 Hospital Hospital NNP cord-005453-4057qib7 14944 16 Universitario Universitario NNP cord-005453-4057qib7 14944 17 Central Central NNP cord-005453-4057qib7 14944 18 de de FW cord-005453-4057qib7 14944 19 Asturias Asturias NNP cord-005453-4057qib7 14944 20 ( ( -LRB- cord-005453-4057qib7 14944 21 Spain Spain NNP cord-005453-4057qib7 14944 22 ) ) -RRB- cord-005453-4057qib7 14944 23 . . . cord-005453-4057qib7 14945 1 Informed informed JJ cord-005453-4057qib7 14945 2 consent consent NN cord-005453-4057qib7 14945 3 was be VBD cord-005453-4057qib7 14945 4 obtained obtain VBN cord-005453-4057qib7 14945 5 from from IN cord-005453-4057qib7 14945 6 each each DT cord-005453-4057qib7 14945 7 mother mother NN cord-005453-4057qib7 14945 8 prior prior RB cord-005453-4057qib7 14945 9 to to IN cord-005453-4057qib7 14945 10 delivery delivery NN cord-005453-4057qib7 14945 11 . . . cord-005453-4057qib7 14946 1 After after IN cord-005453-4057qib7 14946 2 dissection dissection NN cord-005453-4057qib7 14946 3 of of IN cord-005453-4057qib7 14946 4 12 12 CD cord-005453-4057qib7 14946 5 gr gr NNP cord-005453-4057qib7 14946 6 decidual decidual JJ cord-005453-4057qib7 14946 7 tissue tissue NN cord-005453-4057qib7 14946 8 it -PRON- PRP cord-005453-4057qib7 14946 9 was be VBD cord-005453-4057qib7 14946 10 washing wash VBG cord-005453-4057qib7 14946 11 with with IN cord-005453-4057qib7 14946 12 saline saline NN cord-005453-4057qib7 14946 13 ( ( -LRB- cord-005453-4057qib7 14946 14 B. B. NNP cord-005453-4057qib7 14946 15 Braun Braun NNP cord-005453-4057qib7 14946 16 , , , cord-005453-4057qib7 14946 17 Germany Germany NNP cord-005453-4057qib7 14946 18 ) ) -RRB- cord-005453-4057qib7 14946 19 and and CC cord-005453-4057qib7 14946 20 cut cut VBD cord-005453-4057qib7 14946 21 into into IN cord-005453-4057qib7 14946 22 small small JJ cord-005453-4057qib7 14946 23 pieces piece NNS cord-005453-4057qib7 14946 24 . . . cord-005453-4057qib7 14947 1 These these DT cord-005453-4057qib7 14947 2 biopsies biopsy NNS cord-005453-4057qib7 14947 3 were be VBD cord-005453-4057qib7 14947 4 conserved conserve VBN cord-005453-4057qib7 14947 5 24 24 CD cord-005453-4057qib7 14947 6 hours hour NNS cord-005453-4057qib7 14947 7 in in IN cord-005453-4057qib7 14947 8 DMEM DMEM NNP cord-005453-4057qib7 14947 9 media medium NNS cord-005453-4057qib7 14947 10 with with IN cord-005453-4057qib7 14947 11 1 1 CD cord-005453-4057qib7 14947 12 % % NN cord-005453-4057qib7 14947 13 antibiotic antibiotic JJ cord-005453-4057qib7 14947 14 solution solution NN cord-005453-4057qib7 14947 15 100X 100x CD cord-005453-4057qib7 14948 1 ( ( -LRB- cord-005453-4057qib7 14948 2 Gibco Gibco NNP cord-005453-4057qib7 14948 3 , , , cord-005453-4057qib7 14948 4 USAUSA USAUSA NNP cord-005453-4057qib7 14948 5 ) ) -RRB- cord-005453-4057qib7 14948 6 until until IN cord-005453-4057qib7 14948 7 processing processing NN cord-005453-4057qib7 14948 8 . . . cord-005453-4057qib7 14949 1 The the DT cord-005453-4057qib7 14949 2 day day NN cord-005453-4057qib7 14949 3 after after RB cord-005453-4057qib7 14949 4 , , , cord-005453-4057qib7 14949 5 tissue tissue NN cord-005453-4057qib7 14949 6 was be VBD cord-005453-4057qib7 14949 7 mechanically mechanically RB cord-005453-4057qib7 14949 8 minced mince VBN cord-005453-4057qib7 14949 9 and and CC cord-005453-4057qib7 14949 10 then then RB cord-005453-4057qib7 14949 11 enzimatically enzimatically RB cord-005453-4057qib7 14949 12 digested digest VBD cord-005453-4057qib7 14949 13 with with IN cord-005453-4057qib7 14949 14 a a DT cord-005453-4057qib7 14949 15 combination combination NN cord-005453-4057qib7 14949 16 of of IN cord-005453-4057qib7 14949 17 80UI 80ui CD cord-005453-4057qib7 14949 18 / / SYM cord-005453-4057qib7 14949 19 ml ml NN cord-005453-4057qib7 14950 1 DNAse dnase FW cord-005453-4057qib7 14950 2 I -PRON- PRP cord-005453-4057qib7 14950 3 ( ( -LRB- cord-005453-4057qib7 14950 4 Sigma Sigma NNP cord-005453-4057qib7 14950 5 Aldrich Aldrich NNP cord-005453-4057qib7 14950 6 , , , cord-005453-4057qib7 14950 7 USA USA NNP cord-005453-4057qib7 14950 8 ) ) -RRB- cord-005453-4057qib7 14950 9 and and CC cord-005453-4057qib7 14950 10 0.25 0.25 CD cord-005453-4057qib7 14950 11 % % NN cord-005453-4057qib7 14950 12 tripsin tripsin NNP cord-005453-4057qib7 14950 13 - - HYPH cord-005453-4057qib7 14950 14 EDTA EDTA NNP cord-005453-4057qib7 14950 15 solution solution NN cord-005453-4057qib7 14950 16 ( ( -LRB- cord-005453-4057qib7 14950 17 w w NN cord-005453-4057qib7 14950 18 / / SYM cord-005453-4057qib7 14950 19 v v NN cord-005453-4057qib7 14950 20 ) ) -RRB- cord-005453-4057qib7 14951 1 ( ( -LRB- cord-005453-4057qib7 14951 2 Biochrom Biochrom NNP cord-005453-4057qib7 14951 3 , , , cord-005453-4057qib7 14951 4 Germany Germany NNP cord-005453-4057qib7 14951 5 ) ) -RRB- cord-005453-4057qib7 14951 6 at at IN cord-005453-4057qib7 14951 7 37ºC 37ºc CD cord-005453-4057qib7 14951 8 for for IN cord-005453-4057qib7 14951 9 1 1 CD cord-005453-4057qib7 14951 10 hour hour NN cord-005453-4057qib7 14951 11 . . . cord-005453-4057qib7 14952 1 Then then RB cord-005453-4057qib7 14952 2 , , , cord-005453-4057qib7 14952 3 the the DT cord-005453-4057qib7 14952 4 mixture mixture NN cord-005453-4057qib7 14952 5 was be VBD cord-005453-4057qib7 14952 6 filtered filter VBN cord-005453-4057qib7 14952 7 with with IN cord-005453-4057qib7 14952 8 40μm 40μm JJ cord-005453-4057qib7 14952 9 Cell cell NN cord-005453-4057qib7 14952 10 Strainer strainer NN cord-005453-4057qib7 14952 11 ( ( -LRB- cord-005453-4057qib7 14952 12 BD BD NNP cord-005453-4057qib7 14952 13 Bioscience Bioscience NNP cord-005453-4057qib7 14952 14 , , , cord-005453-4057qib7 14952 15 USA USA NNP cord-005453-4057qib7 14952 16 ) ) -RRB- cord-005453-4057qib7 14952 17 and and CC cord-005453-4057qib7 14952 18 centrifuge centrifuge NN cord-005453-4057qib7 14952 19 at at IN cord-005453-4057qib7 14952 20 300xg 300xg NN cord-005453-4057qib7 14952 21 for for IN cord-005453-4057qib7 14952 22 5 5 CD cord-005453-4057qib7 14952 23 minutes minute NNS cord-005453-4057qib7 14952 24 . . . cord-005453-4057qib7 14953 1 Finally finally RB cord-005453-4057qib7 14953 2 , , , cord-005453-4057qib7 14953 3 cells cell NNS cord-005453-4057qib7 14953 4 were be VBD cord-005453-4057qib7 14953 5 resuspended resuspend VBN cord-005453-4057qib7 14953 6 in in IN cord-005453-4057qib7 14953 7 5ml 5ml NN cord-005453-4057qib7 14953 8 of of IN cord-005453-4057qib7 14953 9 DMEM DMEM NNP cord-005453-4057qib7 14953 10 media medium NNS cord-005453-4057qib7 14953 11 suplemented suplemente VBN cord-005453-4057qib7 14953 12 with with IN cord-005453-4057qib7 14953 13 10 10 CD cord-005453-4057qib7 14953 14 % % NN cord-005453-4057qib7 14953 15 FBS fbs NN cord-005453-4057qib7 14953 16 and and CC cord-005453-4057qib7 14953 17 antibiotic antibiotic NN cord-005453-4057qib7 14953 18 , , , cord-005453-4057qib7 14953 19 seeded seed VBN cord-005453-4057qib7 14953 20 in in IN cord-005453-4057qib7 14953 21 24-cm 24-cm CD cord-005453-4057qib7 14953 22 flask flask NN cord-005453-4057qib7 14953 23 and and CC cord-005453-4057qib7 14953 24 incubated incubate VBN cord-005453-4057qib7 14953 25 in in IN cord-005453-4057qib7 14953 26 Forma Forma NNP cord-005453-4057qib7 14953 27 SteriCult SteriCult NNP cord-005453-4057qib7 14953 28 CO CO NNP cord-005453-4057qib7 14953 29 2 2 CD cord-005453-4057qib7 14953 30 incubator incubator NN cord-005453-4057qib7 14953 31 ( ( -LRB- cord-005453-4057qib7 14953 32 Thermo Thermo NNP cord-005453-4057qib7 14953 33 Fisher Fisher NNP cord-005453-4057qib7 14953 34 Scientific Scientific NNP cord-005453-4057qib7 14953 35 , , , cord-005453-4057qib7 14953 36 USA USA NNP cord-005453-4057qib7 14953 37 ) ) -RRB- cord-005453-4057qib7 14953 38 at at IN cord-005453-4057qib7 14953 39 37ºC 37ºc CD cord-005453-4057qib7 14953 40 , , , cord-005453-4057qib7 14953 41 5%CO 5%co CD cord-005453-4057qib7 14953 42 2 2 CD cord-005453-4057qib7 14953 43 . . . cord-005453-4057qib7 14954 1 Culture culture NN cord-005453-4057qib7 14954 2 - - HYPH cord-005453-4057qib7 14954 3 expanded expand VBN cord-005453-4057qib7 14954 4 MSCs mscs NN cord-005453-4057qib7 14954 5 cells cell NNS cord-005453-4057qib7 14954 6 were be VBD cord-005453-4057qib7 14954 7 phenotipically phenotipically RB cord-005453-4057qib7 14954 8 characterized characterize VBN cord-005453-4057qib7 14954 9 by by IN cord-005453-4057qib7 14954 10 flow flow NN cord-005453-4057qib7 14954 11 cytometry cytometry NN cord-005453-4057qib7 14954 12 ( ( -LRB- cord-005453-4057qib7 14954 13 FACS FACS NNP cord-005453-4057qib7 14954 14 Aria Aria NNP cord-005453-4057qib7 14954 15 IIu IIu NNP cord-005453-4057qib7 14954 16 , , , cord-005453-4057qib7 14954 17 BD BD NNP cord-005453-4057qib7 14954 18 ) ) -RRB- cord-005453-4057qib7 14954 19 with with IN cord-005453-4057qib7 14954 20 antibodies antibody NNS cord-005453-4057qib7 14954 21 against against IN cord-005453-4057qib7 14954 22 CD29 CD29 NNP cord-005453-4057qib7 14954 23 , , , cord-005453-4057qib7 14954 24 CD44 CD44 NNP cord-005453-4057qib7 14954 25 , , , cord-005453-4057qib7 14954 26 CD73 CD73 NNP cord-005453-4057qib7 14954 27 , , , cord-005453-4057qib7 14954 28 CD90 CD90 NNP cord-005453-4057qib7 14954 29 , , , cord-005453-4057qib7 14954 30 CD105 CD105 NNP cord-005453-4057qib7 14954 31 , , , cord-005453-4057qib7 14954 32 CD166 CD166 NNP cord-005453-4057qib7 14954 33 , , , cord-005453-4057qib7 14954 34 CD34 CD34 NNP cord-005453-4057qib7 14954 35 , , , cord-005453-4057qib7 14954 36 CD45 CD45 NNP cord-005453-4057qib7 14954 37 , , , cord-005453-4057qib7 14954 38 HLA HLA NNP cord-005453-4057qib7 14954 39 - - HYPH cord-005453-4057qib7 14954 40 DR DR NNP cord-005453-4057qib7 14954 41 CD14 CD14 NNP cord-005453-4057qib7 14954 42 and and CC cord-005453-4057qib7 14954 43 CD19 CD19 NNP cord-005453-4057qib7 14954 44 using use VBG cord-005453-4057qib7 14954 45 Mesenchymal Mesenchymal NNP cord-005453-4057qib7 14954 46 Cell Cell NNP cord-005453-4057qib7 14954 47 Kit kit NN cord-005453-4057qib7 14954 48 ( ( -LRB- cord-005453-4057qib7 14954 49 Immunostep Immunostep NNP cord-005453-4057qib7 14954 50 , , , cord-005453-4057qib7 14954 51 Spain Spain NNP cord-005453-4057qib7 14954 52 ) ) -RRB- cord-005453-4057qib7 14954 53 . . . cord-005453-4057qib7 14955 1 Afterwards afterwards RB cord-005453-4057qib7 14955 2 , , , cord-005453-4057qib7 14955 3 these these DT cord-005453-4057qib7 14955 4 cells cell NNS cord-005453-4057qib7 14955 5 were be VBD cord-005453-4057qib7 14955 6 differentiated differentiate VBN cord-005453-4057qib7 14955 7 to to IN cord-005453-4057qib7 14955 8 adipogenic adipogenic NNP cord-005453-4057qib7 14955 9 , , , cord-005453-4057qib7 14955 10 osteogenic osteogenic JJ cord-005453-4057qib7 14955 11 and and CC cord-005453-4057qib7 14955 12 chondrogenic chondrogenic JJ cord-005453-4057qib7 14955 13 lineages lineage NNS cord-005453-4057qib7 14955 14 using use VBG cord-005453-4057qib7 14955 15 StemMACS StemMACS NNP cord-005453-4057qib7 14955 16 AdipoDiff AdipoDiff NNP cord-005453-4057qib7 14955 17 Media medium NNS cord-005453-4057qib7 14955 18 , , , cord-005453-4057qib7 14955 19 StemMACS StemMACS NNP cord-005453-4057qib7 14955 20 OsteoDiff OsteoDiff NNP cord-005453-4057qib7 14955 21 Media Media NNP cord-005453-4057qib7 14955 22 and and CC cord-005453-4057qib7 14955 23 NH NH NNP cord-005453-4057qib7 14955 24 ChondroDiff ChondroDiff NNP cord-005453-4057qib7 14955 25 Medium Medium NNP cord-005453-4057qib7 14956 1 ( ( -LRB- cord-005453-4057qib7 14956 2 Miltenyi Miltenyi NNP cord-005453-4057qib7 14956 3 Biotec Biotec NNP cord-005453-4057qib7 14956 4 , , , cord-005453-4057qib7 14956 5 Germany Germany NNP cord-005453-4057qib7 14956 6 ) ) -RRB- cord-005453-4057qib7 14956 7 respectively respectively RB cord-005453-4057qib7 14956 8 . . . cord-005453-4057qib7 14957 1 After after IN cord-005453-4057qib7 14957 2 three three CD cord-005453-4057qib7 14957 3 weeks week NNS cord-005453-4057qib7 14957 4 of of IN cord-005453-4057qib7 14957 5 differentiation differentiation NN cord-005453-4057qib7 14957 6 cells cell NNS cord-005453-4057qib7 14957 7 were be VBD cord-005453-4057qib7 14957 8 fixed fix VBN cord-005453-4057qib7 14957 9 in in IN cord-005453-4057qib7 14957 10 4 4 CD cord-005453-4057qib7 14957 11 % % NN cord-005453-4057qib7 14957 12 paraformaldehide paraformaldehide NN cord-005453-4057qib7 14957 13 ( ( -LRB- cord-005453-4057qib7 14957 14 Merck Merck NNP cord-005453-4057qib7 14957 15 , , , cord-005453-4057qib7 14957 16 USA USA NNP cord-005453-4057qib7 14957 17 ) ) -RRB- cord-005453-4057qib7 14957 18 and and CC cord-005453-4057qib7 14957 19 analyzed analyze VBD cord-005453-4057qib7 14957 20 . . . cord-005453-4057qib7 14958 1 Adipogenic Adipogenic NNP cord-005453-4057qib7 14958 2 , , , cord-005453-4057qib7 14958 3 osteogenic osteogenic JJ cord-005453-4057qib7 14958 4 and and CC cord-005453-4057qib7 14958 5 chondrogenic chondrogenic JJ cord-005453-4057qib7 14958 6 differentiation differentiation NN cord-005453-4057qib7 14958 7 was be VBD cord-005453-4057qib7 14958 8 visualized visualize VBN cord-005453-4057qib7 14958 9 after after IN cord-005453-4057qib7 14958 10 staining stain VBG cord-005453-4057qib7 14958 11 with with IN cord-005453-4057qib7 14958 12 Oil Oil NNP cord-005453-4057qib7 14958 13 Red Red NNP cord-005453-4057qib7 14958 14 O o NN cord-005453-4057qib7 14958 15 , , , cord-005453-4057qib7 14958 16 Alkaline Alkaline NNP cord-005453-4057qib7 14958 17 Phosphatase Phosphatase NNP cord-005453-4057qib7 14958 18 and and CC cord-005453-4057qib7 14958 19 Hematoxilin Hematoxilin NNP cord-005453-4057qib7 14958 20 - - HYPH cord-005453-4057qib7 14958 21 Eosin Eosin NNP cord-005453-4057qib7 14958 22 ( ( -LRB- cord-005453-4057qib7 14958 23 Sigma Sigma NNP cord-005453-4057qib7 14958 24 - - HYPH cord-005453-4057qib7 14958 25 Aldrich Aldrich NNP cord-005453-4057qib7 14958 26 , , , cord-005453-4057qib7 14958 27 USA USA NNP cord-005453-4057qib7 14958 28 ) ) -RRB- cord-005453-4057qib7 14958 29 . . . cord-005453-4057qib7 14959 1 Results result NNS cord-005453-4057qib7 14959 2 : : : cord-005453-4057qib7 14960 1 MSCs mscs NN cord-005453-4057qib7 14960 2 - - HYPH cord-005453-4057qib7 14960 3 P p NN cord-005453-4057qib7 14960 4 isolated isolate VBN cord-005453-4057qib7 14960 5 cells cell NNS cord-005453-4057qib7 14960 6 were be VBD cord-005453-4057qib7 14960 7 characterized characterize VBN cord-005453-4057qib7 14960 8 according accord VBG cord-005453-4057qib7 14960 9 to to IN cord-005453-4057qib7 14960 10 the the DT cord-005453-4057qib7 14960 11 ISCT ISCT NNP cord-005453-4057qib7 14960 12 criteria criterion NNS cord-005453-4057qib7 14960 13 for for IN cord-005453-4057qib7 14960 14 mesenchymal mesenchymal JJ cord-005453-4057qib7 14960 15 stem stem NN cord-005453-4057qib7 14960 16 cells cell NNS cord-005453-4057qib7 14960 17 . . . cord-005453-4057qib7 14961 1 They -PRON- PRP cord-005453-4057qib7 14961 2 were be VBD cord-005453-4057qib7 14961 3 positive positive JJ cord-005453-4057qib7 14961 4 for for IN cord-005453-4057qib7 14961 5 CD29 CD29 NNP cord-005453-4057qib7 14961 6 , , , cord-005453-4057qib7 14961 7 CD44 CD44 NNP cord-005453-4057qib7 14961 8 , , , cord-005453-4057qib7 14961 9 CD73 CD73 NNP cord-005453-4057qib7 14961 10 , , , cord-005453-4057qib7 14961 11 CD90 CD90 NNP cord-005453-4057qib7 14961 12 and and CC cord-005453-4057qib7 14961 13 CD105 CD105 NNP cord-005453-4057qib7 14961 14 and and CC cord-005453-4057qib7 14961 15 negative negative JJ cord-005453-4057qib7 14961 16 for for IN cord-005453-4057qib7 14961 17 CD14 CD14 NNP cord-005453-4057qib7 14961 18 , , , cord-005453-4057qib7 14961 19 CD34 CD34 NNP cord-005453-4057qib7 14961 20 , , , cord-005453-4057qib7 14961 21 CD45 CD45 NNP cord-005453-4057qib7 14961 22 and and CC cord-005453-4057qib7 14961 23 HLA HLA NNP cord-005453-4057qib7 14961 24 - - HYPH cord-005453-4057qib7 14961 25 DR DR NNP cord-005453-4057qib7 14961 26 , , , cord-005453-4057qib7 14961 27 indicative indicative JJ cord-005453-4057qib7 14961 28 of of IN cord-005453-4057qib7 14961 29 a a DT cord-005453-4057qib7 14961 30 typical typical JJ cord-005453-4057qib7 14961 31 MSC MSC NNP cord-005453-4057qib7 14961 32 phenotype phenotype NN cord-005453-4057qib7 14961 33 ( ( -LRB- cord-005453-4057qib7 14961 34 Figure figure NN cord-005453-4057qib7 14961 35 1 1 CD cord-005453-4057qib7 14961 36 ) ) -RRB- cord-005453-4057qib7 14961 37 . . . cord-005453-4057qib7 14962 1 All all PDT cord-005453-4057qib7 14962 2 the the DT cord-005453-4057qib7 14962 3 markers marker NNS cord-005453-4057qib7 14962 4 showed show VBD cord-005453-4057qib7 14962 5 a a DT cord-005453-4057qib7 14962 6 high high JJ cord-005453-4057qib7 14962 7 percentage percentage NN cord-005453-4057qib7 14962 8 of of IN cord-005453-4057qib7 14962 9 expression expression NN cord-005453-4057qib7 14962 10 between between IN cord-005453-4057qib7 14962 11 84.6 84.6 CD cord-005453-4057qib7 14962 12 and and CC cord-005453-4057qib7 14962 13 99.9 99.9 CD cord-005453-4057qib7 14962 14 % % NN cord-005453-4057qib7 14962 15 , , , cord-005453-4057qib7 14962 16 meaning mean VBG cord-005453-4057qib7 14962 17 that that IN cord-005453-4057qib7 14962 18 MSC MSC NNP cord-005453-4057qib7 14962 19 population population NN cord-005453-4057qib7 14962 20 obtained obtain VBN cord-005453-4057qib7 14962 21 with with IN cord-005453-4057qib7 14962 22 the the DT cord-005453-4057qib7 14962 23 designed design VBN cord-005453-4057qib7 14962 24 method method NN cord-005453-4057qib7 14962 25 was be VBD cord-005453-4057qib7 14962 26 very very RB cord-005453-4057qib7 14962 27 homogenous homogenous JJ cord-005453-4057qib7 14962 28 . . . cord-005453-4057qib7 14963 1 Similarly similarly RB cord-005453-4057qib7 14963 2 , , , cord-005453-4057qib7 14963 3 staining stain VBG cord-005453-4057qib7 14963 4 for for IN cord-005453-4057qib7 14963 5 the the DT cord-005453-4057qib7 14963 6 three three CD cord-005453-4057qib7 14963 7 studied study VBN cord-005453-4057qib7 14963 8 lineages lineage NNS cord-005453-4057qib7 14963 9 was be VBD cord-005453-4057qib7 14963 10 positive positive JJ cord-005453-4057qib7 14963 11 ( ( -LRB- cord-005453-4057qib7 14963 12 Figure figure NN cord-005453-4057qib7 14963 13 1 1 CD cord-005453-4057qib7 14963 14 ) ) -RRB- cord-005453-4057qib7 14963 15 . . . cord-005453-4057qib7 14964 1 Conclusions conclusion NNS cord-005453-4057qib7 14964 2 : : : cord-005453-4057qib7 14965 1 The the DT cord-005453-4057qib7 14965 2 described describe VBN cord-005453-4057qib7 14965 3 protocol protocol NN cord-005453-4057qib7 14965 4 allows allow VBZ cord-005453-4057qib7 14965 5 us -PRON- PRP cord-005453-4057qib7 14965 6 to to TO cord-005453-4057qib7 14965 7 obtain obtain VB cord-005453-4057qib7 14965 8 MSCs mscs NN cord-005453-4057qib7 14965 9 from from IN cord-005453-4057qib7 14965 10 decidual decidual JJ cord-005453-4057qib7 14965 11 placental placental NN cord-005453-4057qib7 14965 12 tissue tissue NN cord-005453-4057qib7 14965 13 stored store VBN cord-005453-4057qib7 14965 14 and and CC cord-005453-4057qib7 14965 15 processed process VBN cord-005453-4057qib7 14965 16 24 24 CD cord-005453-4057qib7 14965 17 hours hour NNS cord-005453-4057qib7 14965 18 after after IN cord-005453-4057qib7 14965 19 the the DT cord-005453-4057qib7 14965 20 biopsy biopsy NN cord-005453-4057qib7 14965 21 extraction extraction NN cord-005453-4057qib7 14965 22 using use VBG cord-005453-4057qib7 14965 23 a a DT cord-005453-4057qib7 14965 24 unique unique JJ cord-005453-4057qib7 14965 25 enzymatic enzymatic JJ cord-005453-4057qib7 14965 26 digestion digestion NN cord-005453-4057qib7 14965 27 . . . cord-005453-4057qib7 14966 1 This this DT cord-005453-4057qib7 14966 2 circumstance circumstance NN cord-005453-4057qib7 14966 3 permits permit VBZ cord-005453-4057qib7 14966 4 to to TO cord-005453-4057qib7 14966 5 take take VB cord-005453-4057qib7 14966 6 advantage advantage NN cord-005453-4057qib7 14966 7 of of IN cord-005453-4057qib7 14966 8 placentas placenta NNS cord-005453-4057qib7 14966 9 that that WDT cord-005453-4057qib7 14966 10 are be VBP cord-005453-4057qib7 14966 11 discarded discard VBN cord-005453-4057qib7 14966 12 after after IN cord-005453-4057qib7 14966 13 delivery delivery NN cord-005453-4057qib7 14966 14 giving give VBG cord-005453-4057qib7 14966 15 us -PRON- PRP cord-005453-4057qib7 14966 16 the the DT cord-005453-4057qib7 14966 17 option option NN cord-005453-4057qib7 14966 18 to to TO cord-005453-4057qib7 14966 19 obtain obtain VB cord-005453-4057qib7 14966 20 mesenchymal mesenchymal JJ cord-005453-4057qib7 14966 21 cells cell NNS cord-005453-4057qib7 14966 22 that that WDT cord-005453-4057qib7 14966 23 could could MD cord-005453-4057qib7 14966 24 be be VB cord-005453-4057qib7 14966 25 used use VBN cord-005453-4057qib7 14966 26 in in IN cord-005453-4057qib7 14966 27 clinical clinical JJ cord-005453-4057qib7 14966 28 trials trial NNS cord-005453-4057qib7 14966 29 . . . cord-005453-4057qib7 14967 1 Disclosure disclosure NN cord-005453-4057qib7 14967 2 : : : cord-005453-4057qib7 14967 3 Nothing nothing NN cord-005453-4057qib7 14967 4 to to TO cord-005453-4057qib7 14967 5 declare declare VB cord-005453-4057qib7 14967 6 Outcomes outcome NNS cord-005453-4057qib7 14967 7 of of IN cord-005453-4057qib7 14967 8 umbilical umbilical JJ cord-005453-4057qib7 14967 9 cord cord NN cord-005453-4057qib7 14967 10 transplant transplant NN cord-005453-4057qib7 14967 11 in in IN cord-005453-4057qib7 14967 12 high high JJ cord-005453-4057qib7 14967 13 risk risk NN cord-005453-4057qib7 14967 14 relapsed relapse VBD cord-005453-4057qib7 14967 15 or or CC cord-005453-4057qib7 14967 16 refractory refractory JJ cord-005453-4057qib7 14968 1 acute acute JJ cord-005453-4057qib7 14968 2 myeloid myeloid NN cord-005453-4057qib7 14968 3 leukaemia leukaemia NN cord-005453-4057qib7 14968 4 Background background NN cord-005453-4057qib7 14968 5 : : : cord-005453-4057qib7 14968 6 High high JJ cord-005453-4057qib7 14968 7 - - HYPH cord-005453-4057qib7 14968 8 risk risk NN cord-005453-4057qib7 14968 9 relapsed relapse VBN cord-005453-4057qib7 14968 10 / / SYM cord-005453-4057qib7 14968 11 refractory refractory JJ cord-005453-4057qib7 14968 12 acute acute JJ cord-005453-4057qib7 14968 13 myeloid myeloid NN cord-005453-4057qib7 14968 14 leukaemia leukaemia NN cord-005453-4057qib7 14968 15 ( ( -LRB- cord-005453-4057qib7 14968 16 AML AML NNP cord-005453-4057qib7 14968 17 ) ) -RRB- cord-005453-4057qib7 14968 18 is be VBZ cord-005453-4057qib7 14968 19 a a DT cord-005453-4057qib7 14968 20 fatal fatal JJ cord-005453-4057qib7 14968 21 disease disease NN cord-005453-4057qib7 14968 22 . . . cord-005453-4057qib7 14969 1 Allogeneic allogeneic IN cord-005453-4057qib7 14969 2 haematopoietic haematopoietic JJ cord-005453-4057qib7 14969 3 stem stem NN cord-005453-4057qib7 14969 4 cell cell NN cord-005453-4057qib7 14969 5 transplantation transplantation NN cord-005453-4057qib7 14969 6 represents represent VBZ cord-005453-4057qib7 14969 7 the the DT cord-005453-4057qib7 14969 8 only only JJ cord-005453-4057qib7 14969 9 chance chance NN cord-005453-4057qib7 14969 10 of of IN cord-005453-4057qib7 14969 11 cure cure NN cord-005453-4057qib7 14969 12 . . . cord-005453-4057qib7 14970 1 As as IN cord-005453-4057qib7 14970 2 the the DT cord-005453-4057qib7 14970 3 transplant transplant NN cord-005453-4057qib7 14970 4 relies rely VBZ cord-005453-4057qib7 14970 5 on on IN cord-005453-4057qib7 14970 6 the the DT cord-005453-4057qib7 14970 7 graft graft NN cord-005453-4057qib7 14970 8 - - HYPH cord-005453-4057qib7 14970 9 versusleukaemia versusleukaemia NN cord-005453-4057qib7 14970 10 ( ( -LRB- cord-005453-4057qib7 14970 11 GvL gvl NN cord-005453-4057qib7 14970 12 ) ) -RRB- cord-005453-4057qib7 14970 13 effect effect NN cord-005453-4057qib7 14970 14 , , , cord-005453-4057qib7 14970 15 and and CC cord-005453-4057qib7 14970 16 if if IN cord-005453-4057qib7 14970 17 different different JJ cord-005453-4057qib7 14970 18 donors donor NNS cord-005453-4057qib7 14970 19 exert exert VBP cord-005453-4057qib7 14970 20 different different JJ cord-005453-4057qib7 14970 21 GvL gvl NN cord-005453-4057qib7 14970 22 effects effect NNS cord-005453-4057qib7 14970 23 , , , cord-005453-4057qib7 14970 24 then then RB cord-005453-4057qib7 14970 25 choosing choose VBG cord-005453-4057qib7 14970 26 the the DT cord-005453-4057qib7 14970 27 right right JJ cord-005453-4057qib7 14970 28 donor donor NN cord-005453-4057qib7 14970 29 assumes assume VBZ cord-005453-4057qib7 14970 30 great great JJ cord-005453-4057qib7 14970 31 importance importance NN cord-005453-4057qib7 14970 32 . . . cord-005453-4057qib7 14971 1 In in IN cord-005453-4057qib7 14971 2 Manchester Manchester NNP cord-005453-4057qib7 14971 3 , , , cord-005453-4057qib7 14971 4 a a DT cord-005453-4057qib7 14971 5 large large JJ cord-005453-4057qib7 14971 6 BMT BMT NNP cord-005453-4057qib7 14971 7 centre centre NN cord-005453-4057qib7 14971 8 in in IN cord-005453-4057qib7 14971 9 the the DT cord-005453-4057qib7 14971 10 north north NN cord-005453-4057qib7 14971 11 of of IN cord-005453-4057qib7 14971 12 England England NNP cord-005453-4057qib7 14971 13 , , , cord-005453-4057qib7 14971 14 our -PRON- PRP$ cord-005453-4057qib7 14971 15 practice practice NN cord-005453-4057qib7 14971 16 in in IN cord-005453-4057qib7 14971 17 such such JJ cord-005453-4057qib7 14971 18 AML AML NNP cord-005453-4057qib7 14971 19 has have VBZ cord-005453-4057qib7 14971 20 been be VBN cord-005453-4057qib7 14971 21 to to TO cord-005453-4057qib7 14971 22 choose choose VB cord-005453-4057qib7 14971 23 unrelated unrelated JJ cord-005453-4057qib7 14971 24 cord cord NN cord-005453-4057qib7 14971 25 blood blood NN cord-005453-4057qib7 14971 26 ( ( -LRB- cord-005453-4057qib7 14971 27 UCBT UCBT NNP cord-005453-4057qib7 14971 28 ) ) -RRB- cord-005453-4057qib7 14971 29 , , , cord-005453-4057qib7 14971 30 without without IN cord-005453-4057qib7 14971 31 serotherapy serotherapy NN cord-005453-4057qib7 14971 32 in in IN cord-005453-4057qib7 14971 33 the the DT cord-005453-4057qib7 14971 34 conditioning conditioning NN cord-005453-4057qib7 14971 35 therapy therapy NN cord-005453-4057qib7 14971 36 , , , cord-005453-4057qib7 14971 37 as as IN cord-005453-4057qib7 14971 38 our -PRON- PRP$ cord-005453-4057qib7 14971 39 preferred preferred JJ cord-005453-4057qib7 14971 40 donor donor NN cord-005453-4057qib7 14971 41 cell cell NN cord-005453-4057qib7 14971 42 source source NN cord-005453-4057qib7 14971 43 . . . cord-005453-4057qib7 14972 1 Methods method NNS cord-005453-4057qib7 14973 1 : : : cord-005453-4057qib7 14973 2 We -PRON- PRP cord-005453-4057qib7 14973 3 report report VBP cord-005453-4057qib7 14973 4 the the DT cord-005453-4057qib7 14973 5 results result NNS cord-005453-4057qib7 14973 6 of of IN cord-005453-4057qib7 14973 7 16 16 CD cord-005453-4057qib7 14973 8 unrelated unrelated JJ cord-005453-4057qib7 14973 9 UCBT UCBT NNPS cord-005453-4057qib7 14973 10 in in IN cord-005453-4057qib7 14973 11 15 15 CD cord-005453-4057qib7 14973 12 patients patient NNS cord-005453-4057qib7 14973 13 ( ( -LRB- cord-005453-4057qib7 14973 14 five five CD cord-005453-4057qib7 14973 15 boys boy NNS cord-005453-4057qib7 14973 16 and and CC cord-005453-4057qib7 14973 17 ten ten CD cord-005453-4057qib7 14973 18 girls girl NNS cord-005453-4057qib7 14973 19 ) ) -RRB- cord-005453-4057qib7 14973 20 with with IN cord-005453-4057qib7 14973 21 high high JJ cord-005453-4057qib7 14973 22 - - HYPH cord-005453-4057qib7 14973 23 risk risk NN cord-005453-4057qib7 14973 24 AML AML NNP cord-005453-4057qib7 14973 25 , , , cord-005453-4057qib7 14973 26 defined define VBN cord-005453-4057qib7 14973 27 as as IN cord-005453-4057qib7 14973 28 relapsed relapsed JJ cord-005453-4057qib7 14973 29 or or CC cord-005453-4057qib7 14973 30 refractory refractory JJ cord-005453-4057qib7 14973 31 disease disease NN cord-005453-4057qib7 14973 32 . . . cord-005453-4057qib7 14974 1 Thirteen thirteen CD cord-005453-4057qib7 14974 2 patients patient NNS cord-005453-4057qib7 14974 3 ( ( -LRB- cord-005453-4057qib7 14974 4 81 81 CD cord-005453-4057qib7 14974 5 % % NN cord-005453-4057qib7 14974 6 ) ) -RRB- cord-005453-4057qib7 14974 7 received receive VBD cord-005453-4057qib7 14974 8 this this DT cord-005453-4057qib7 14974 9 as as IN cord-005453-4057qib7 14974 10 a a DT cord-005453-4057qib7 14974 11 1 1 CD cord-005453-4057qib7 14974 12 st st NNP cord-005453-4057qib7 14974 13 transplant transplant NN cord-005453-4057qib7 14974 14 , , , cord-005453-4057qib7 14974 15 two two CD cord-005453-4057qib7 14974 16 Patients patient NNS cord-005453-4057qib7 14974 17 ( ( -LRB- cord-005453-4057qib7 14974 18 13 13 CD cord-005453-4057qib7 14974 19 % % NN cord-005453-4057qib7 14974 20 ) ) -RRB- cord-005453-4057qib7 14974 21 received receive VBD cord-005453-4057qib7 14974 22 this this DT cord-005453-4057qib7 14974 23 as as IN cord-005453-4057qib7 14974 24 a a DT cord-005453-4057qib7 14974 25 2 2 CD cord-005453-4057qib7 14974 26 nd nd NNP cord-005453-4057qib7 14974 27 transplant transplant NN cord-005453-4057qib7 14974 28 for for IN cord-005453-4057qib7 14974 29 relapsed relapse VBN cord-005453-4057qib7 14974 30 AML AML NNP cord-005453-4057qib7 14974 31 post post NN cord-005453-4057qib7 14974 32 matched match VBN cord-005453-4057qib7 14974 33 unrelated unrelated JJ cord-005453-4057qib7 14974 34 donor donor NN cord-005453-4057qib7 14974 35 transplant transplant NN cord-005453-4057qib7 14974 36 , , , cord-005453-4057qib7 14974 37 and and CC cord-005453-4057qib7 14974 38 one one CD cord-005453-4057qib7 14974 39 ( ( -LRB- cord-005453-4057qib7 14974 40 6 6 CD cord-005453-4057qib7 14974 41 % % NN cord-005453-4057qib7 14974 42 ) ) -RRB- cord-005453-4057qib7 14974 43 received receive VBD cord-005453-4057qib7 14974 44 UCBT UCBT NNP cord-005453-4057qib7 14974 45 twice twice RB cord-005453-4057qib7 14974 46 , , , cord-005453-4057qib7 14974 47 once once RB cord-005453-4057qib7 14974 48 in in IN cord-005453-4057qib7 14974 49 CR1 CR1 NNP cord-005453-4057qib7 14974 50 and and CC cord-005453-4057qib7 14974 51 once once RB cord-005453-4057qib7 14974 52 in in IN cord-005453-4057qib7 14974 53 CR2 CR2 NNP cord-005453-4057qib7 14974 54 . . . cord-005453-4057qib7 14975 1 Nine nine CD cord-005453-4057qib7 14975 2 patients patient NNS cord-005453-4057qib7 14975 3 ( ( -LRB- cord-005453-4057qib7 14975 4 56 56 CD cord-005453-4057qib7 14975 5 % % NN cord-005453-4057qib7 14975 6 ) ) -RRB- cord-005453-4057qib7 14975 7 had have VBD cord-005453-4057qib7 14975 8 mismatched mismatch VBN cord-005453-4057qib7 14975 9 UCBT UCBT NNP cord-005453-4057qib7 14975 10 , , , cord-005453-4057qib7 14975 11 and and CC cord-005453-4057qib7 14975 12 the the DT cord-005453-4057qib7 14975 13 rest rest NN cord-005453-4057qib7 14975 14 were be VBD cord-005453-4057qib7 14975 15 fully fully RB cord-005453-4057qib7 14975 16 matched match VBN cord-005453-4057qib7 14975 17 at at IN cord-005453-4057qib7 14975 18 class class NN cord-005453-4057qib7 14975 19 - - : cord-005453-4057qib7 14975 20 I i JJ cord-005453-4057qib7 14975 21 ( ( -LRB- cord-005453-4057qib7 14975 22 HLA HLA NNP cord-005453-4057qib7 14975 23 - - HYPH cord-005453-4057qib7 14975 24 A A NNP cord-005453-4057qib7 14975 25 , , , cord-005453-4057qib7 14975 26 -B -b ADD cord-005453-4057qib7 14975 27 , , , cord-005453-4057qib7 14975 28 and and CC cord-005453-4057qib7 14975 29 - - HYPH cord-005453-4057qib7 14975 30 C c NN cord-005453-4057qib7 14975 31 ) ) -RRB- cord-005453-4057qib7 14975 32 and and CC cord-005453-4057qib7 14975 33 class class NN cord-005453-4057qib7 14975 34 - - HYPH cord-005453-4057qib7 14975 35 II II NNP cord-005453-4057qib7 14975 36 ( ( -LRB- cord-005453-4057qib7 14975 37 HLA HLA NNP cord-005453-4057qib7 14975 38 - - HYPH cord-005453-4057qib7 14975 39 DRB1 DRB1 NNP cord-005453-4057qib7 14975 40 ) ) -RRB- cord-005453-4057qib7 14975 41 . . . cord-005453-4057qib7 14976 1 Conditioning conditioning NN cord-005453-4057qib7 14976 2 was be VBD cord-005453-4057qib7 14976 3 given give VBN cord-005453-4057qib7 14976 4 as as IN cord-005453-4057qib7 14976 5 Treosulfan Treosulfan NNP cord-005453-4057qib7 14976 6 , , , cord-005453-4057qib7 14976 7 Fludarabine Fludarabine NNP cord-005453-4057qib7 14976 8 and and CC cord-005453-4057qib7 14976 9 Thiotepa Thiotepa NNP cord-005453-4057qib7 14976 10 in in IN cord-005453-4057qib7 14976 11 half half NN cord-005453-4057qib7 14976 12 of of IN cord-005453-4057qib7 14976 13 the the DT cord-005453-4057qib7 14976 14 patients patient NNS cord-005453-4057qib7 14976 15 ( ( -LRB- cord-005453-4057qib7 14976 16 n n NN cord-005453-4057qib7 14976 17 = = SYM cord-005453-4057qib7 14976 18 8) 8) NN cord-005453-4057qib7 14976 19 , , , cord-005453-4057qib7 14977 1 other other JJ cord-005453-4057qib7 14977 2 Treosulfanbased treosulfanbased JJ cord-005453-4057qib7 14977 3 regimens regimen NNS cord-005453-4057qib7 14977 4 were be VBD cord-005453-4057qib7 14977 5 used use VBN cord-005453-4057qib7 14977 6 in in IN cord-005453-4057qib7 14977 7 two two CD cord-005453-4057qib7 14977 8 patients patient NNS cord-005453-4057qib7 14977 9 ( ( -LRB- cord-005453-4057qib7 14977 10 12 12 CD cord-005453-4057qib7 14977 11 % % NN cord-005453-4057qib7 14977 12 ) ) -RRB- cord-005453-4057qib7 14977 13 , , , cord-005453-4057qib7 14977 14 and and CC cord-005453-4057qib7 14977 15 Busulfan Busulfan NNP cord-005453-4057qib7 14977 16 - - HYPH cord-005453-4057qib7 14977 17 based base VBN cord-005453-4057qib7 14977 18 regimens regimen NNS cord-005453-4057qib7 14977 19 were be VBD cord-005453-4057qib7 14977 20 used use VBN cord-005453-4057qib7 14977 21 in in IN cord-005453-4057qib7 14977 22 six six CD cord-005453-4057qib7 14977 23 patients patient NNS cord-005453-4057qib7 14977 24 ( ( -LRB- cord-005453-4057qib7 14977 25 38 38 CD cord-005453-4057qib7 14977 26 % % NN cord-005453-4057qib7 14977 27 ) ) -RRB- cord-005453-4057qib7 14977 28 . . . cord-005453-4057qib7 14978 1 No no DT cord-005453-4057qib7 14978 2 serotherapy serotherapy NN cord-005453-4057qib7 14978 3 was be VBD cord-005453-4057qib7 14978 4 given give VBN cord-005453-4057qib7 14978 5 . . . cord-005453-4057qib7 14979 1 Results result NNS cord-005453-4057qib7 14979 2 : : : cord-005453-4057qib7 14980 1 The the DT cord-005453-4057qib7 14980 2 median median JJ cord-005453-4057qib7 14980 3 age age NN cord-005453-4057qib7 14980 4 at at IN cord-005453-4057qib7 14980 5 transplant transplant NN cord-005453-4057qib7 14980 6 was be VBD cord-005453-4057qib7 14980 7 5 5 CD cord-005453-4057qib7 14980 8 years year NNS cord-005453-4057qib7 14981 1 ( ( -LRB- cord-005453-4057qib7 14981 2 Range range NN cord-005453-4057qib7 14981 3 , , , cord-005453-4057qib7 14981 4 5months 5months JJ cord-005453-4057qib7 14981 5 -15years -15year NNS cord-005453-4057qib7 14981 6 ) ) -RRB- cord-005453-4057qib7 14981 7 . . . cord-005453-4057qib7 14982 1 Neutrophil Neutrophil NNP cord-005453-4057qib7 14982 2 and and CC cord-005453-4057qib7 14982 3 platelet platelet NN cord-005453-4057qib7 14982 4 engraftment engraftment NN cord-005453-4057qib7 14982 5 were be VBD cord-005453-4057qib7 14982 6 achieved achieve VBN cord-005453-4057qib7 14982 7 in in IN cord-005453-4057qib7 14982 8 15 15 CD cord-005453-4057qib7 14982 9 and and CC cord-005453-4057qib7 14982 10 12 12 CD cord-005453-4057qib7 14982 11 patients patient NNS cord-005453-4057qib7 14982 12 at at IN cord-005453-4057qib7 14982 13 a a DT cord-005453-4057qib7 14982 14 median median NN cord-005453-4057qib7 14982 15 of of IN cord-005453-4057qib7 14982 16 16 16 CD cord-005453-4057qib7 14982 17 and and CC cord-005453-4057qib7 14982 18 35 35 CD cord-005453-4057qib7 14982 19 days day NNS cord-005453-4057qib7 14982 20 , , , cord-005453-4057qib7 14982 21 respectively respectively RB cord-005453-4057qib7 14982 22 . . . cord-005453-4057qib7 14983 1 13 13 CD cord-005453-4057qib7 14983 2 patients patient NNS cord-005453-4057qib7 14983 3 ( ( -LRB- cord-005453-4057qib7 14983 4 81 81 CD cord-005453-4057qib7 14983 5 % % NN cord-005453-4057qib7 14983 6 ) ) -RRB- cord-005453-4057qib7 14983 7 had have VBD cord-005453-4057qib7 14983 8 engraftment engraftment NNP cord-005453-4057qib7 14983 9 syndrome syndrome NN cord-005453-4057qib7 14983 10 . . . cord-005453-4057qib7 14984 1 All all DT cord-005453-4057qib7 14984 2 engrafted engraft VBN cord-005453-4057qib7 14984 3 patients patient NNS cord-005453-4057qib7 14984 4 achieved achieve VBD cord-005453-4057qib7 14984 5 100 100 CD cord-005453-4057qib7 14984 6 % % NN cord-005453-4057qib7 14984 7 donor donor NN cord-005453-4057qib7 14984 8 chimerism chimerism NN cord-005453-4057qib7 14984 9 , , , cord-005453-4057qib7 14984 10 except except IN cord-005453-4057qib7 14984 11 one one CD cord-005453-4057qib7 14984 12 patient patient NN cord-005453-4057qib7 14984 13 who who WP cord-005453-4057qib7 14984 14 had have VBD cord-005453-4057qib7 14984 15 mixed mix VBN cord-005453-4057qib7 14984 16 lymphoid lymphoid JJ cord-005453-4057qib7 14984 17 chimerism chimerism NN cord-005453-4057qib7 14984 18 initially initially RB cord-005453-4057qib7 14984 19 , , , cord-005453-4057qib7 14984 20 that that WDT cord-005453-4057qib7 14984 21 was be VBD cord-005453-4057qib7 14984 22 corrected correct VBN cord-005453-4057qib7 14984 23 spontaneously spontaneously RB cord-005453-4057qib7 14984 24 to to IN cord-005453-4057qib7 14984 25 100 100 CD cord-005453-4057qib7 14984 26 % % NN cord-005453-4057qib7 14984 27 at at IN cord-005453-4057qib7 14984 28 three three CD cord-005453-4057qib7 14984 29 months month NNS cord-005453-4057qib7 14984 30 after after IN cord-005453-4057qib7 14984 31 transplant transplant NN cord-005453-4057qib7 14984 32 . . . cord-005453-4057qib7 14985 1 Acute acute JJ cord-005453-4057qib7 14985 2 GVHD GVHD NNP cord-005453-4057qib7 14985 3 Grade Grade NNP cord-005453-4057qib7 14985 4 I I NNP cord-005453-4057qib7 14985 5 - - HYPH cord-005453-4057qib7 14985 6 II II NNP cord-005453-4057qib7 14985 7 developed develop VBD cord-005453-4057qib7 14985 8 in in IN cord-005453-4057qib7 14985 9 six six CD cord-005453-4057qib7 14985 10 patients patient NNS cord-005453-4057qib7 14985 11 ( ( -LRB- cord-005453-4057qib7 14985 12 38 38 CD cord-005453-4057qib7 14985 13 % % NN cord-005453-4057qib7 14985 14 ) ) -RRB- cord-005453-4057qib7 14985 15 , , , cord-005453-4057qib7 14985 16 and and CC cord-005453-4057qib7 14985 17 Grade Grade NNP cord-005453-4057qib7 14985 18 III III NNP cord-005453-4057qib7 14985 19 - - HYPH cord-005453-4057qib7 14985 20 IV IV NNP cord-005453-4057qib7 14985 21 developed develop VBD cord-005453-4057qib7 14985 22 in in IN cord-005453-4057qib7 14985 23 three three CD cord-005453-4057qib7 14985 24 patients patient NNS cord-005453-4057qib7 14985 25 ( ( -LRB- cord-005453-4057qib7 14985 26 19 19 CD cord-005453-4057qib7 14985 27 % % NN cord-005453-4057qib7 14985 28 ) ) -RRB- cord-005453-4057qib7 14985 29 . . . cord-005453-4057qib7 14986 1 All all DT cord-005453-4057qib7 14986 2 cases case NNS cord-005453-4057qib7 14986 3 resolved resolve VBD cord-005453-4057qib7 14986 4 , , , cord-005453-4057qib7 14986 5 except except IN cord-005453-4057qib7 14986 6 two two CD cord-005453-4057qib7 14986 7 patients patient NNS cord-005453-4057qib7 14986 8 where where WRB cord-005453-4057qib7 14986 9 acute acute JJ cord-005453-4057qib7 14986 10 GVHD GVHD NNP cord-005453-4057qib7 14986 11 evolved evolve VBD cord-005453-4057qib7 14986 12 into into IN cord-005453-4057qib7 14986 13 Chronic Chronic NNP cord-005453-4057qib7 14986 14 GVHD GVHD NNP cord-005453-4057qib7 14986 15 ( ( -LRB- cord-005453-4057qib7 14986 16 One one CD cord-005453-4057qib7 14986 17 with with IN cord-005453-4057qib7 14986 18 Grade grade NN cord-005453-4057qib7 14987 1 I -PRON- PRP cord-005453-4057qib7 14987 2 skin skin VBP cord-005453-4057qib7 14987 3 GVHD GVHD NNP cord-005453-4057qib7 14987 4 which which WDT cord-005453-4057qib7 14987 5 fully fully RB cord-005453-4057qib7 14987 6 resolved resolve VBD cord-005453-4057qib7 14987 7 , , , cord-005453-4057qib7 14987 8 and and CC cord-005453-4057qib7 14987 9 one one CD cord-005453-4057qib7 14987 10 with with IN cord-005453-4057qib7 14987 11 Grade Grade NNP cord-005453-4057qib7 14987 12 III III NNP cord-005453-4057qib7 14987 13 GVHD GVHD NNP cord-005453-4057qib7 14987 14 gut gut NN cord-005453-4057qib7 14987 15 colitis colitis NN cord-005453-4057qib7 14987 16 who who WP cord-005453-4057qib7 14987 17 was be VBD cord-005453-4057qib7 14987 18 parenteral parenteral JJ cord-005453-4057qib7 14987 19 nutrition nutrition NN cord-005453-4057qib7 14987 20 dependent dependent JJ cord-005453-4057qib7 14987 21 till till IN cord-005453-4057qib7 14987 22 death death NN cord-005453-4057qib7 14987 23 ) ) -RRB- cord-005453-4057qib7 14987 24 . . . cord-005453-4057qib7 14988 1 Two two CD cord-005453-4057qib7 14988 2 more more JJR cord-005453-4057qib7 14988 3 patients patient NNS cord-005453-4057qib7 14988 4 developed develop VBD cord-005453-4057qib7 14988 5 Chronic Chronic NNP cord-005453-4057qib7 14988 6 Grade grade NN cord-005453-4057qib7 14989 1 I -PRON- PRP cord-005453-4057qib7 14989 2 skin skin VBP cord-005453-4057qib7 14989 3 GVHD GVHD NNP cord-005453-4057qib7 14989 4 and and CC cord-005453-4057qib7 14989 5 resolved resolve VBD cord-005453-4057qib7 14990 1 ( ( -LRB- cord-005453-4057qib7 14990 2 Chronic Chronic NNP cord-005453-4057qib7 14990 3 GVHD GVHD NNP cord-005453-4057qib7 14990 4 developed develop VBN cord-005453-4057qib7 14990 5 in in IN cord-005453-4057qib7 14990 6 25 25 CD cord-005453-4057qib7 14990 7 % % NN cord-005453-4057qib7 14990 8 in in IN cord-005453-4057qib7 14990 9 total total NN cord-005453-4057qib7 14990 10 ) ) -RRB- cord-005453-4057qib7 14990 11 . . . cord-005453-4057qib7 14991 1 Three three CD cord-005453-4057qib7 14991 2 patients patient NNS cord-005453-4057qib7 14991 3 ( ( -LRB- cord-005453-4057qib7 14991 4 17 17 CD cord-005453-4057qib7 14991 5 % % NN cord-005453-4057qib7 14991 6 ) ) -RRB- cord-005453-4057qib7 14991 7 developed develop VBD cord-005453-4057qib7 14991 8 veno veno NNP cord-005453-4057qib7 14991 9 - - HYPH cord-005453-4057qib7 14991 10 occlusive occlusive JJ cord-005453-4057qib7 14991 11 disease disease NN cord-005453-4057qib7 14991 12 ( ( -LRB- cord-005453-4057qib7 14991 13 VOD VOD NNP cord-005453-4057qib7 14991 14 ) ) -RRB- cord-005453-4057qib7 14991 15 , , , cord-005453-4057qib7 14991 16 that that WDT cord-005453-4057qib7 14991 17 completely completely RB cord-005453-4057qib7 14991 18 resolved resolve VBN cord-005453-4057qib7 14991 19 with with IN cord-005453-4057qib7 14991 20 defibrotide defibrotide NN cord-005453-4057qib7 14991 21 treatment treatment NN cord-005453-4057qib7 14991 22 and and CC cord-005453-4057qib7 14991 23 necessitated necessitate VBD cord-005453-4057qib7 14991 24 ascitic ascitic JJ cord-005453-4057qib7 14991 25 drainage drainage NN cord-005453-4057qib7 14991 26 in in IN cord-005453-4057qib7 14991 27 one one CD cord-005453-4057qib7 14991 28 of of IN cord-005453-4057qib7 14991 29 them -PRON- PRP cord-005453-4057qib7 14991 30 . . . cord-005453-4057qib7 14992 1 Viral viral JJ cord-005453-4057qib7 14992 2 reactivations reactivation NNS cord-005453-4057qib7 14992 3 occurred occur VBD cord-005453-4057qib7 14992 4 in in IN cord-005453-4057qib7 14992 5 five five CD cord-005453-4057qib7 14992 6 patients patient NNS cord-005453-4057qib7 14992 7 ( ( -LRB- cord-005453-4057qib7 14992 8 30 30 CD cord-005453-4057qib7 14992 9 % % NN cord-005453-4057qib7 14992 10 ) ) -RRB- cord-005453-4057qib7 14992 11 and and CC cord-005453-4057qib7 14992 12 were be VBD cord-005453-4057qib7 14992 13 successfully successfully RB cord-005453-4057qib7 14992 14 treated treat VBN cord-005453-4057qib7 14992 15 . . . cord-005453-4057qib7 14993 1 At at IN cord-005453-4057qib7 14993 2 a a DT cord-005453-4057qib7 14993 3 median median JJ cord-005453-4057qib7 14993 4 follow follow NN cord-005453-4057qib7 14993 5 - - HYPH cord-005453-4057qib7 14993 6 up up NN cord-005453-4057qib7 14993 7 of of IN cord-005453-4057qib7 14993 8 20 20 CD cord-005453-4057qib7 14993 9 months month NNS cord-005453-4057qib7 14993 10 ( ( -LRB- cord-005453-4057qib7 14993 11 Range range NN cord-005453-4057qib7 14993 12 , , , cord-005453-4057qib7 14993 13 seven seven CD cord-005453-4057qib7 14993 14 months month NNS cord-005453-4057qib7 14993 15 -four -four JJR cord-005453-4057qib7 14993 16 years year NNS cord-005453-4057qib7 14993 17 ) ) -RRB- cord-005453-4057qib7 14993 18 , , , cord-005453-4057qib7 14993 19 eight eight CD cord-005453-4057qib7 14993 20 patients patient NNS cord-005453-4057qib7 14993 21 ( ( -LRB- cord-005453-4057qib7 14993 22 50 50 CD cord-005453-4057qib7 14993 23 % % NN cord-005453-4057qib7 14993 24 ) ) -RRB- cord-005453-4057qib7 14993 25 died die VBD cord-005453-4057qib7 14993 26 at at IN cord-005453-4057qib7 14993 27 a a DT cord-005453-4057qib7 14993 28 median median NN cord-005453-4057qib7 14993 29 of of IN cord-005453-4057qib7 14993 30 79 79 CD cord-005453-4057qib7 14993 31 ( ( -LRB- cord-005453-4057qib7 14993 32 Range Range NNP cord-005453-4057qib7 14993 33 , , , cord-005453-4057qib7 14993 34 24 24 CD cord-005453-4057qib7 14993 35 to to TO cord-005453-4057qib7 14993 36 230 230 CD cord-005453-4057qib7 14993 37 days day NNS cord-005453-4057qib7 14993 38 ) ) -RRB- cord-005453-4057qib7 14993 39 , , , cord-005453-4057qib7 14993 40 with with IN cord-005453-4057qib7 14993 41 a a DT cord-005453-4057qib7 14993 42 transplantrelated transplantrelated JJ cord-005453-4057qib7 14993 43 mortality mortality NN cord-005453-4057qib7 14993 44 of of IN cord-005453-4057qib7 14993 45 25 25 CD cord-005453-4057qib7 14993 46 % % NN cord-005453-4057qib7 14993 47 and and CC cord-005453-4057qib7 14993 48 relapse relapse NN cord-005453-4057qib7 14993 49 - - HYPH cord-005453-4057qib7 14993 50 related relate VBN cord-005453-4057qib7 14993 51 mortality mortality NN cord-005453-4057qib7 14993 52 of of IN cord-005453-4057qib7 14993 53 25 25 CD cord-005453-4057qib7 14993 54 % % NN cord-005453-4057qib7 14993 55 . . . cord-005453-4057qib7 14994 1 Five five CD cord-005453-4057qib7 14994 2 patients patient NNS cord-005453-4057qib7 14994 3 ( ( -LRB- cord-005453-4057qib7 14994 4 31 31 CD cord-005453-4057qib7 14994 5 % % NN cord-005453-4057qib7 14994 6 ) ) -RRB- cord-005453-4057qib7 14994 7 relapsed relapse VBN cord-005453-4057qib7 14994 8 post post NN cord-005453-4057qib7 14994 9 - - NNS cord-005453-4057qib7 14994 10 UCBT UCBT NNPS cord-005453-4057qib7 14994 11 ; ; : cord-005453-4057qib7 14994 12 four four CD cord-005453-4057qib7 14994 13 died die VBD cord-005453-4057qib7 14994 14 and and CC cord-005453-4057qib7 14994 15 one one PRP cord-005453-4057qib7 14994 16 had have VBD cord-005453-4057qib7 14994 17 a a DT cord-005453-4057qib7 14994 18 successful successful JJ cord-005453-4057qib7 14994 19 second second JJ cord-005453-4057qib7 14994 20 UCBT UCBT NNPS cord-005453-4057qib7 14994 21 ( ( -LRB- cord-005453-4057qib7 14994 22 event event NN cord-005453-4057qib7 14994 23 - - HYPH cord-005453-4057qib7 14994 24 free free JJ cord-005453-4057qib7 14994 25 survival survival NN cord-005453-4057qib7 14994 26 was be VBD cord-005453-4057qib7 14994 27 44 44 CD cord-005453-4057qib7 14994 28 % % NN cord-005453-4057qib7 14994 29 ) ) -RRB- cord-005453-4057qib7 14994 30 . . . cord-005453-4057qib7 14995 1 Immune immune JJ cord-005453-4057qib7 14995 2 reconstitution reconstitution NN cord-005453-4057qib7 14995 3 in in IN cord-005453-4057qib7 14995 4 alive alive JJ cord-005453-4057qib7 14995 5 patients patient NNS cord-005453-4057qib7 14995 6 was be VBD cord-005453-4057qib7 14995 7 achieved achieve VBN cord-005453-4057qib7 14995 8 at at IN cord-005453-4057qib7 14995 9 a a DT cord-005453-4057qib7 14995 10 median median NN cord-005453-4057qib7 14995 11 of of IN cord-005453-4057qib7 14995 12 eight eight CD cord-005453-4057qib7 14995 13 months month NNS cord-005453-4057qib7 14995 14 . . . cord-005453-4057qib7 14996 1 Conclusions conclusion NNS cord-005453-4057qib7 14996 2 : : : cord-005453-4057qib7 14997 1 Very very RB cord-005453-4057qib7 14997 2 high high JJ cord-005453-4057qib7 14997 3 - - HYPH cord-005453-4057qib7 14997 4 risk risk NN cord-005453-4057qib7 14997 5 patients patient NNS cord-005453-4057qib7 14997 6 treated treat VBN cord-005453-4057qib7 14997 7 with with IN cord-005453-4057qib7 14997 8 UCBT UCBT NNS cord-005453-4057qib7 14997 9 with with IN cord-005453-4057qib7 14997 10 good good JJ cord-005453-4057qib7 14997 11 overall overall JJ cord-005453-4057qib7 14997 12 survival survival NN cord-005453-4057qib7 14997 13 and and CC cord-005453-4057qib7 14997 14 event event NN cord-005453-4057qib7 14997 15 - - HYPH cord-005453-4057qib7 14997 16 free free JJ cord-005453-4057qib7 14997 17 survival survival NN cord-005453-4057qib7 14997 18 , , , cord-005453-4057qib7 14997 19 similar similar JJ cord-005453-4057qib7 14997 20 to to IN cord-005453-4057qib7 14997 21 AML AML NNP cord-005453-4057qib7 14997 22 treatment treatment NN cord-005453-4057qib7 14997 23 rate rate NN cord-005453-4057qib7 14997 24 with with IN cord-005453-4057qib7 14997 25 low low JJ cord-005453-4057qib7 14997 26 - - HYPH cord-005453-4057qib7 14997 27 risk risk NN cord-005453-4057qib7 14997 28 disease disease NN cord-005453-4057qib7 14997 29 . . . cord-005453-4057qib7 14998 1 Disclosure disclosure NN cord-005453-4057qib7 14998 2 : : : cord-005453-4057qib7 14998 3 Nothing nothing NN cord-005453-4057qib7 14998 4 to to TO cord-005453-4057qib7 14998 5 declare declare VB cord-005453-4057qib7 14998 6 In in IN cord-005453-4057qib7 14998 7 haploidentical haploidentical JJ cord-005453-4057qib7 14998 8 transplants transplant NNS cord-005453-4057qib7 14998 9 is be VBZ cord-005453-4057qib7 14998 10 the the DT cord-005453-4057qib7 14998 11 incidence incidence NN cord-005453-4057qib7 14998 12 of of IN cord-005453-4057qib7 14998 13 acute acute JJ cord-005453-4057qib7 14998 14 and and CC cord-005453-4057qib7 14998 15 chronic chronic JJ cord-005453-4057qib7 14998 16 GVHD GVHD NNP cord-005453-4057qib7 14998 17 strictly strictly RB cord-005453-4057qib7 14998 18 related related JJ cord-005453-4057qib7 14998 19 to to IN cord-005453-4057qib7 14998 20 the the DT cord-005453-4057qib7 14998 21 stem stem NN cord-005453-4057qib7 14998 22 cell cell NN cord-005453-4057qib7 14998 23 source source NN cord-005453-4057qib7 14998 24 ? ? . cord-005453-4057qib7 14999 1 Results result NNS cord-005453-4057qib7 14999 2 : : : cord-005453-4057qib7 15000 1 The the DT cord-005453-4057qib7 15000 2 odds odd NNS cord-005453-4057qib7 15000 3 ratio ratio NN cord-005453-4057qib7 15000 4 was be VBD cord-005453-4057qib7 15000 5 1.78 1.78 CD cord-005453-4057qib7 15000 6 with with IN cord-005453-4057qib7 15000 7 a a DT cord-005453-4057qib7 15000 8 95 95 CD cord-005453-4057qib7 15000 9 % % NN cord-005453-4057qib7 15000 10 confidence confidence NN cord-005453-4057qib7 15000 11 interval interval NN cord-005453-4057qib7 15000 12 of of IN cord-005453-4057qib7 15000 13 0.94 0.94 CD cord-005453-4057qib7 15000 14 -3.37 -3.37 CD cord-005453-4057qib7 15000 15 ( ( -LRB- cord-005453-4057qib7 15000 16 p=0.07 p=0.07 NNP cord-005453-4057qib7 15000 17 ) ) -RRB- cord-005453-4057qib7 15000 18 . . . cord-005453-4057qib7 15001 1 Conclusions conclusion NNS cord-005453-4057qib7 15001 2 : : : cord-005453-4057qib7 15002 1 The the DT cord-005453-4057qib7 15002 2 risk risk NN cord-005453-4057qib7 15002 3 of of IN cord-005453-4057qib7 15002 4 infection infection NN cord-005453-4057qib7 15002 5 of of IN cord-005453-4057qib7 15002 6 the the DT cord-005453-4057qib7 15002 7 UC UC NNP cord-005453-4057qib7 15002 8 is be VBZ cord-005453-4057qib7 15002 9 not not RB cord-005453-4057qib7 15002 10 related relate VBN cord-005453-4057qib7 15002 11 to to IN cord-005453-4057qib7 15002 12 the the DT cord-005453-4057qib7 15002 13 microbiological microbiological JJ cord-005453-4057qib7 15002 14 status status NN cord-005453-4057qib7 15002 15 of of IN cord-005453-4057qib7 15002 16 the the DT cord-005453-4057qib7 15002 17 UCB UCB NNP cord-005453-4057qib7 15002 18 . . . cord-005453-4057qib7 15003 1 A a DT cord-005453-4057qib7 15003 2 possible possible JJ cord-005453-4057qib7 15003 3 explanation explanation NN cord-005453-4057qib7 15003 4 for for IN cord-005453-4057qib7 15003 5 this this DT cord-005453-4057qib7 15003 6 is be VBZ cord-005453-4057qib7 15003 7 the the DT cord-005453-4057qib7 15003 8 presence presence NN cord-005453-4057qib7 15003 9 of of IN cord-005453-4057qib7 15003 10 antibiotics antibiotic NNS cord-005453-4057qib7 15003 11 in in IN cord-005453-4057qib7 15003 12 the the DT cord-005453-4057qib7 15003 13 medium medium NN cord-005453-4057qib7 15003 14 used use VBN cord-005453-4057qib7 15003 15 for for IN cord-005453-4057qib7 15003 16 UC UC NNP cord-005453-4057qib7 15003 17 , , , cord-005453-4057qib7 15003 18 but but CC cord-005453-4057qib7 15003 19 not not RB cord-005453-4057qib7 15003 20 UCB UCB NNP cord-005453-4057qib7 15003 21 , , , cord-005453-4057qib7 15003 22 transport transport NN cord-005453-4057qib7 15003 23 . . . cord-005453-4057qib7 15004 1 This this DT cord-005453-4057qib7 15004 2 means mean VBZ cord-005453-4057qib7 15004 3 that that IN cord-005453-4057qib7 15004 4 cryopreservation cryopreservation NN cord-005453-4057qib7 15004 5 of of IN cord-005453-4057qib7 15004 6 UCs uc NNS cord-005453-4057qib7 15004 7 from from IN cord-005453-4057qib7 15004 8 which which WDT cord-005453-4057qib7 15004 9 contaminated contaminate VBD cord-005453-4057qib7 15004 10 cord cord NN cord-005453-4057qib7 15004 11 blood blood NN cord-005453-4057qib7 15004 12 has have VBZ cord-005453-4057qib7 15004 13 been be VBN cord-005453-4057qib7 15004 14 obtained obtain VBN cord-005453-4057qib7 15004 15 is be VBZ cord-005453-4057qib7 15004 16 justified justify VBN cord-005453-4057qib7 15004 17 . . . cord-005453-4057qib7 15004 18 _SP cord-005453-4057qib7 15005 1 Comparison comparison NN cord-005453-4057qib7 15005 2 of of IN cord-005453-4057qib7 15005 3 turkish turkish JJ cord-005453-4057qib7 15005 4 stem stem NN cord-005453-4057qib7 15005 5 cell cell NN cord-005453-4057qib7 15005 6 coordination coordination NN cord-005453-4057qib7 15005 7 center center NN cord-005453-4057qib7 15005 8 ( ( -LRB- cord-005453-4057qib7 15005 9 TURKOK TURKOK NNP cord-005453-4057qib7 15005 10 ) ) -RRB- cord-005453-4057qib7 15005 11 with with IN cord-005453-4057qib7 15005 12 Istanbul Istanbul NNP cord-005453-4057qib7 15005 13 university university NN cord-005453-4057qib7 15005 14 bone bone NN cord-005453-4057qib7 15005 15 marrow marrow NN cord-005453-4057qib7 15005 16 bank bank NN cord-005453-4057qib7 15005 17 ( ( -LRB- cord-005453-4057qib7 15005 18 TRIS TRIS NNP cord-005453-4057qib7 15005 19 ) ) -RRB- cord-005453-4057qib7 15005 20 ; ; : cord-005453-4057qib7 15005 21 A a DT cord-005453-4057qib7 15005 22 single single JJ cord-005453-4057qib7 15005 23 center center NN cord-005453-4057qib7 15005 24 experience experience NN cord-005453-4057qib7 15005 25 in in IN cord-005453-4057qib7 15005 26 match match NN cord-005453-4057qib7 15005 27 unrelated unrelated JJ cord-005453-4057qib7 15005 28 donors donor NNS cord-005453-4057qib7 15005 29 Azize Azize NNP cord-005453-4057qib7 15005 30 Mergen Mergen NNP cord-005453-4057qib7 15005 31 1 1 CD cord-005453-4057qib7 15005 32 , , , cord-005453-4057qib7 15005 33 Selime Selime NNP cord-005453-4057qib7 15005 34 Aydoğdu Aydoğdu NNP cord-005453-4057qib7 15005 35 2 2 CD cord-005453-4057qib7 15005 36 , , , cord-005453-4057qib7 15005 37 Başak Başak NNP cord-005453-4057qib7 15005 38 Aksoy Aksoy NNP cord-005453-4057qib7 15005 39 3 3 CD cord-005453-4057qib7 15005 40 , , , cord-005453-4057qib7 15005 41 Yunus Yunus NNP cord-005453-4057qib7 15005 42 Emre Emre NNP cord-005453-4057qib7 15005 43 Savcı Savcı NNP cord-005453-4057qib7 15005 44 2 2 CD cord-005453-4057qib7 15005 45 , , , cord-005453-4057qib7 15005 46 Gürcan Gürcan NNP cord-005453-4057qib7 15005 47 Dikme Dikme NNP cord-005453-4057qib7 15005 48 2 2 CD cord-005453-4057qib7 15005 49 , , , cord-005453-4057qib7 15005 50 Funda Funda NNP cord-005453-4057qib7 15005 51 Çipe Çipe NNP cord-005453-4057qib7 15005 52 2 2 CD cord-005453-4057qib7 15005 53 , , , cord-005453-4057qib7 15005 54 Ceyhun Ceyhun NNP cord-005453-4057qib7 15005 55 Bozkurt Bozkurt NNP cord-005453-4057qib7 15005 56 3 3 CD cord-005453-4057qib7 15005 57 , , , cord-005453-4057qib7 15005 58 Tunç Tunç NNP cord-005453-4057qib7 15005 59 Fışgın Fışgın NNP cord-005453-4057qib7 15005 60 1 1 CD cord-005453-4057qib7 15006 1 Older old JJR cord-005453-4057qib7 15006 2 patients patient NNS cord-005453-4057qib7 15006 3 are be VBP cord-005453-4057qib7 15006 4 increasingly increasingly RB cord-005453-4057qib7 15006 5 being be VBG cord-005453-4057qib7 15006 6 transplanted transplant VBN cord-005453-4057qib7 15006 7 , , , cord-005453-4057qib7 15006 8 thanks thank NNS cord-005453-4057qib7 15006 9 to to IN cord-005453-4057qib7 15006 10 improvement improvement NN cord-005453-4057qib7 15006 11 in in IN cord-005453-4057qib7 15006 12 allogeneic allogeneic JJ cord-005453-4057qib7 15006 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 15006 14 stem stem NN cord-005453-4057qib7 15006 15 cell cell NN cord-005453-4057qib7 15006 16 transplantation transplantation NN cord-005453-4057qib7 15006 17 ( ( -LRB- cord-005453-4057qib7 15006 18 allo allo NN cord-005453-4057qib7 15006 19 - - HYPH cord-005453-4057qib7 15006 20 HSCT HSCT NNP cord-005453-4057qib7 15006 21 ) ) -RRB- cord-005453-4057qib7 15006 22 techniques technique NNS cord-005453-4057qib7 15006 23 . . . cord-005453-4057qib7 15007 1 Increasing increase VBG cord-005453-4057qib7 15007 2 donor donor NN cord-005453-4057qib7 15007 3 age age NN cord-005453-4057qib7 15007 4 is be VBZ cord-005453-4057qib7 15007 5 associated associate VBN cord-005453-4057qib7 15007 6 with with IN cord-005453-4057qib7 15007 7 greater great JJR cord-005453-4057qib7 15007 8 risk risk NN cord-005453-4057qib7 15007 9 for for IN cord-005453-4057qib7 15007 10 mortality mortality NN cord-005453-4057qib7 15007 11 and and CC cord-005453-4057qib7 15007 12 graftversus graftversus NN cord-005453-4057qib7 15007 13 - - HYPH cord-005453-4057qib7 15007 14 host host NN cord-005453-4057qib7 15007 15 disease disease NN cord-005453-4057qib7 15007 16 ( ( -LRB- cord-005453-4057qib7 15007 17 GVHD GVHD NNP cord-005453-4057qib7 15007 18 ) ) -RRB- cord-005453-4057qib7 15007 19 . . . cord-005453-4057qib7 15008 1 Since since IN cord-005453-4057qib7 15008 2 sibling sibling NN cord-005453-4057qib7 15008 3 donors donor NNS cord-005453-4057qib7 15008 4 are be VBP cord-005453-4057qib7 15008 5 of of IN cord-005453-4057qib7 15008 6 similar similar JJ cord-005453-4057qib7 15008 7 age age NN cord-005453-4057qib7 15008 8 to to IN cord-005453-4057qib7 15008 9 recipients recipient NNS cord-005453-4057qib7 15008 10 , , , cord-005453-4057qib7 15008 11 we -PRON- PRP cord-005453-4057qib7 15008 12 hypothesized hypothesize VBD cord-005453-4057qib7 15008 13 that that IN cord-005453-4057qib7 15008 14 , , , cord-005453-4057qib7 15008 15 in in IN cord-005453-4057qib7 15008 16 older old JJR cord-005453-4057qib7 15008 17 patients patient NNS cord-005453-4057qib7 15008 18 , , , cord-005453-4057qib7 15008 19 a a DT cord-005453-4057qib7 15008 20 young young JJ cord-005453-4057qib7 15008 21 matched match VBN cord-005453-4057qib7 15008 22 unrelated unrelated JJ cord-005453-4057qib7 15008 23 donor donor NN cord-005453-4057qib7 15008 24 ( ( -LRB- cord-005453-4057qib7 15008 25 MUD mud NN cord-005453-4057qib7 15008 26 ) ) -RRB- cord-005453-4057qib7 15008 27 would would MD cord-005453-4057qib7 15008 28 be be VB cord-005453-4057qib7 15008 29 comparable comparable JJ cord-005453-4057qib7 15008 30 to to IN cord-005453-4057qib7 15008 31 an an DT cord-005453-4057qib7 15008 32 HLA HLA NNP cord-005453-4057qib7 15008 33 - - HYPH cord-005453-4057qib7 15008 34 matched match VBN cord-005453-4057qib7 15008 35 sibling sibling NN cord-005453-4057qib7 15008 36 donor donor NN cord-005453-4057qib7 15008 37 ( ( -LRB- cord-005453-4057qib7 15008 38 MSD MSD NNP cord-005453-4057qib7 15008 39 ) ) -RRB- cord-005453-4057qib7 15008 40 . . . cord-005453-4057qib7 15009 1 Methods method NNS cord-005453-4057qib7 15009 2 : : : cord-005453-4057qib7 15009 3 We -PRON- PRP cord-005453-4057qib7 15009 4 retrospectively retrospectively RB cord-005453-4057qib7 15009 5 compared compare VBD cord-005453-4057qib7 15009 6 outcomes outcome NNS cord-005453-4057qib7 15009 7 of of IN cord-005453-4057qib7 15009 8 allo allo NN cord-005453-4057qib7 15009 9 - - HYPH cord-005453-4057qib7 15009 10 HSCT HSCT NNP cord-005453-4057qib7 15009 11 from from IN cord-005453-4057qib7 15009 12 MSD MSD NNP cord-005453-4057qib7 15009 13 ( ( -LRB- cord-005453-4057qib7 15009 14 n=1797 n=1797 CD cord-005453-4057qib7 15009 15 ) ) -RRB- cord-005453-4057qib7 15009 16 and and CC cord-005453-4057qib7 15009 17 10/10 10/10 CD cord-005453-4057qib7 15009 18 HLA HLA NNP cord-005453-4057qib7 15009 19 MUD MUD NNP cord-005453-4057qib7 15009 20 ( ( -LRB- cord-005453-4057qib7 15009 21 n=2212 n=2212 CD cord-005453-4057qib7 15009 22 ) ) -RRB- cord-005453-4057qib7 15009 23 in in IN cord-005453-4057qib7 15009 24 patients patient NNS cord-005453-4057qib7 15009 25 aged age VBN cord-005453-4057qib7 15009 26 ≥ ≥ CD cord-005453-4057qib7 15009 27 60 60 CD cord-005453-4057qib7 15009 28 years year NNS cord-005453-4057qib7 15009 29 with with IN cord-005453-4057qib7 15009 30 hematological hematological JJ cord-005453-4057qib7 15009 31 malignancies malignancy NNS cord-005453-4057qib7 15009 32 transplanted transplant VBN cord-005453-4057qib7 15009 33 between between IN cord-005453-4057qib7 15009 34 2006 2006 CD cord-005453-4057qib7 15009 35 - - SYM cord-005453-4057qib7 15009 36 2015 2015 CD cord-005453-4057qib7 15009 37 . . . cord-005453-4057qib7 15010 1 All all DT cord-005453-4057qib7 15010 2 patients patient NNS cord-005453-4057qib7 15010 3 received receive VBD cord-005453-4057qib7 15010 4 reduced reduce VBN cord-005453-4057qib7 15010 5 - - HYPH cord-005453-4057qib7 15010 6 intensity intensity NN cord-005453-4057qib7 15010 7 conditioning conditioning NN cord-005453-4057qib7 15010 8 and and CC cord-005453-4057qib7 15010 9 graft graft NN cord-005453-4057qib7 15010 10 source source NN cord-005453-4057qib7 15010 11 was be VBD cord-005453-4057qib7 15010 12 peripheral peripheral JJ cord-005453-4057qib7 15010 13 blood blood NN cord-005453-4057qib7 15010 14 . . . cord-005453-4057qib7 15011 1 The the DT cord-005453-4057qib7 15011 2 primary primary JJ cord-005453-4057qib7 15011 3 outcome outcome NN cord-005453-4057qib7 15011 4 was be VBD cord-005453-4057qib7 15011 5 overall overall JJ cord-005453-4057qib7 15011 6 survival survival NN cord-005453-4057qib7 15011 7 . . . cord-005453-4057qib7 15012 1 MSDs msd NNS cord-005453-4057qib7 15012 2 served serve VBD cord-005453-4057qib7 15012 3 as as IN cord-005453-4057qib7 15012 4 the the DT cord-005453-4057qib7 15012 5 reference reference NN cord-005453-4057qib7 15012 6 category category NN cord-005453-4057qib7 15012 7 and and CC cord-005453-4057qib7 15012 8 were be VBD cord-005453-4057qib7 15012 9 compared compare VBN cord-005453-4057qib7 15012 10 to to IN cord-005453-4057qib7 15012 11 MUDs mud NNS cord-005453-4057qib7 15012 12 split split VBD cord-005453-4057qib7 15012 13 into into IN cord-005453-4057qib7 15012 14 three three CD cord-005453-4057qib7 15012 15 age age NN cord-005453-4057qib7 15012 16 groups group NNS cord-005453-4057qib7 15012 17 ( ( -LRB- cord-005453-4057qib7 15012 18 ≤25 ≤25 NNP cord-005453-4057qib7 15012 19 [ [ -LRB- cord-005453-4057qib7 15012 20 n=524 n=524 NNP cord-005453-4057qib7 15012 21 ] ] -RRB- cord-005453-4057qib7 15012 22 , , , cord-005453-4057qib7 15012 23 25 25 CD cord-005453-4057qib7 15012 24 - - SYM cord-005453-4057qib7 15012 25 40 40 CD cord-005453-4057qib7 15012 26 [ [ -LRB- cord-005453-4057qib7 15012 27 n=1072 n=1072 CD cord-005453-4057qib7 15012 28 ] ] -RRB- cord-005453-4057qib7 15012 29 , , , cord-005453-4057qib7 15012 30 > > XX cord-005453-4057qib7 15013 1 40 40 CD cord-005453-4057qib7 15013 2 [ [ -LRB- cord-005453-4057qib7 15013 3 n=616 n=616 NNP cord-005453-4057qib7 15013 4 ] ] -RRB- cord-005453-4057qib7 15013 5 years year NNS cord-005453-4057qib7 15013 6 ) ) -RRB- cord-005453-4057qib7 15013 7 using use VBG cord-005453-4057qib7 15013 8 univariable univariable JJ cord-005453-4057qib7 15013 9 analyses analysis NNS cord-005453-4057qib7 15013 10 and and CC cord-005453-4057qib7 15013 11 multivariable multivariable JJ cord-005453-4057qib7 15013 12 Cox Cox NNP cord-005453-4057qib7 15013 13 regression regression NN cord-005453-4057qib7 15013 14 models model NNS cord-005453-4057qib7 15013 15 adjusted adjust VBN cord-005453-4057qib7 15013 16 for for IN cord-005453-4057qib7 15013 17 patient patient NN cord-005453-4057qib7 15013 18 , , , cord-005453-4057qib7 15013 19 disease disease NN cord-005453-4057qib7 15013 20 , , , cord-005453-4057qib7 15013 21 and and CC cord-005453-4057qib7 15013 22 transplantation transplantation NN cord-005453-4057qib7 15013 23 features feature NNS cord-005453-4057qib7 15013 24 . . . cord-005453-4057qib7 15014 1 Results result NNS cord-005453-4057qib7 15014 2 : : : cord-005453-4057qib7 15015 1 The the DT cord-005453-4057qib7 15015 2 median median JJ cord-005453-4057qib7 15015 3 age age NN cord-005453-4057qib7 15015 4 of of IN cord-005453-4057qib7 15015 5 HSCT HSCT NNP cord-005453-4057qib7 15015 6 recipients recipient NNS cord-005453-4057qib7 15015 7 was be VBD cord-005453-4057qib7 15015 8 64 64 CD cord-005453-4057qib7 15015 9 years year NNS cord-005453-4057qib7 15015 10 and and CC cord-005453-4057qib7 15015 11 was be VBD cord-005453-4057qib7 15015 12 similar similar JJ cord-005453-4057qib7 15015 13 across across IN cord-005453-4057qib7 15015 14 groups group NNS cord-005453-4057qib7 15015 15 . . . cord-005453-4057qib7 15016 1 Median median JJ cord-005453-4057qib7 15016 2 donor donor NN cord-005453-4057qib7 15016 3 age age NN cord-005453-4057qib7 15016 4 for for IN cord-005453-4057qib7 15016 5 MSD MSD NNP cord-005453-4057qib7 15016 6 was be VBD cord-005453-4057qib7 15016 7 60 60 CD cord-005453-4057qib7 15016 8 years year NNS cord-005453-4057qib7 15016 9 and and CC cord-005453-4057qib7 15016 10 22 22 CD cord-005453-4057qib7 15016 11 , , , cord-005453-4057qib7 15016 12 33 33 CD cord-005453-4057qib7 15016 13 , , , cord-005453-4057qib7 15016 14 and and CC cord-005453-4057qib7 15016 15 45 45 CD cord-005453-4057qib7 15016 16 for for IN cord-005453-4057qib7 15016 17 the the DT cord-005453-4057qib7 15016 18 MUD MUD NNP cord-005453-4057qib7 15016 19 age age NN cord-005453-4057qib7 15016 20 groups group NNS cord-005453-4057qib7 15017 1 ≤25 ≤25 NNP cord-005453-4057qib7 15017 2 , , , cord-005453-4057qib7 15017 3 25 25 CD cord-005453-4057qib7 15017 4 - - SYM cord-005453-4057qib7 15017 5 40 40 CD cord-005453-4057qib7 15017 6 , , , cord-005453-4057qib7 15017 7 and and CC cord-005453-4057qib7 15017 8 > > XX cord-005453-4057qib7 15017 9 40 40 CD cord-005453-4057qib7 15017 10 years year NNS cord-005453-4057qib7 15017 11 . . . cord-005453-4057qib7 15018 1 Acute acute JJ cord-005453-4057qib7 15018 2 leukemia leukemia NN cord-005453-4057qib7 15018 3 was be VBD cord-005453-4057qib7 15018 4 the the DT cord-005453-4057qib7 15018 5 leading lead VBG cord-005453-4057qib7 15018 6 transplant transplant NN cord-005453-4057qib7 15018 7 indication indication NN cord-005453-4057qib7 15018 8 ( ( -LRB- cord-005453-4057qib7 15018 9 46 46 CD cord-005453-4057qib7 15018 10 % % NN cord-005453-4057qib7 15018 11 ) ) -RRB- cord-005453-4057qib7 15018 12 followed follow VBN cord-005453-4057qib7 15018 13 by by IN cord-005453-4057qib7 15018 14 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 15018 15 syndrome syndrome NN cord-005453-4057qib7 15018 16 , , , cord-005453-4057qib7 15018 17 myeloproliferative myeloproliferative JJ cord-005453-4057qib7 15018 18 neoplasms neoplasm NNS cord-005453-4057qib7 15018 19 and and CC cord-005453-4057qib7 15018 20 indolent indolent JJ cord-005453-4057qib7 15018 21 non non JJ cord-005453-4057qib7 15018 22 - - JJ cord-005453-4057qib7 15018 23 Hodgkin Hodgkin NNP cord-005453-4057qib7 15018 24 lymphoma lymphoma NN cord-005453-4057qib7 15018 25 . . . cord-005453-4057qib7 15019 1 Disease disease NN cord-005453-4057qib7 15019 2 risk risk NN cord-005453-4057qib7 15019 3 distribution distribution NN cord-005453-4057qib7 15019 4 was be VBD cord-005453-4057qib7 15019 5 similar similar JJ cord-005453-4057qib7 15019 6 across across IN cord-005453-4057qib7 15019 7 donor donor NN cord-005453-4057qib7 15019 8 groups group NNS cord-005453-4057qib7 15019 9 ( ( -LRB- cord-005453-4057qib7 15019 10 low low JJ cord-005453-4057qib7 15019 11 [ [ -LRB- cord-005453-4057qib7 15019 12 48 48 CD cord-005453-4057qib7 15019 13 % % NN cord-005453-4057qib7 15019 14 ] ] -RRB- cord-005453-4057qib7 15019 15 , , , cord-005453-4057qib7 15019 16 intermediate intermediate JJ cord-005453-4057qib7 15019 17 [ [ -LRB- cord-005453-4057qib7 15019 18 42 42 CD cord-005453-4057qib7 15019 19 % % NN cord-005453-4057qib7 15019 20 ] ] -RRB- cord-005453-4057qib7 15019 21 , , , cord-005453-4057qib7 15019 22 and and CC cord-005453-4057qib7 15019 23 high high JJ cord-005453-4057qib7 15019 24 [ [ -LRB- cord-005453-4057qib7 15019 25 10 10 CD cord-005453-4057qib7 15019 26 % % NN cord-005453-4057qib7 15019 27 ] ] -RRB- cord-005453-4057qib7 15019 28 in in IN cord-005453-4057qib7 15019 29 the the DT cord-005453-4057qib7 15019 30 complete complete JJ cord-005453-4057qib7 15019 31 population population NN cord-005453-4057qib7 15019 32 ; ; : cord-005453-4057qib7 15019 33 p=0.771 p=0.771 ADD cord-005453-4057qib7 15019 34 ) ) -RRB- cord-005453-4057qib7 15019 35 . . . cord-005453-4057qib7 15020 1 Time time NN cord-005453-4057qib7 15020 2 from from IN cord-005453-4057qib7 15020 3 diagnosis diagnosis NN cord-005453-4057qib7 15020 4 to to IN cord-005453-4057qib7 15020 5 HSCT HSCT NNP cord-005453-4057qib7 15020 6 was be VBD cord-005453-4057qib7 15020 7 longer long JJR cord-005453-4057qib7 15020 8 with with IN cord-005453-4057qib7 15020 9 MUD mud NN cord-005453-4057qib7 15020 10 compared compare VBN cord-005453-4057qib7 15020 11 to to IN cord-005453-4057qib7 15020 12 MSD MSD NNP cord-005453-4057qib7 15020 13 and and CC cord-005453-4057qib7 15020 14 increased increase VBD cord-005453-4057qib7 15020 15 with with IN cord-005453-4057qib7 15020 16 an an DT cord-005453-4057qib7 15020 17 older old JJR cord-005453-4057qib7 15020 18 age age NN cord-005453-4057qib7 15020 19 of of IN cord-005453-4057qib7 15020 20 MUD mud NN cord-005453-4057qib7 15020 21 . . . cord-005453-4057qib7 15021 1 In in IN cord-005453-4057qib7 15021 2 a a DT cord-005453-4057qib7 15021 3 univariate univariate JJ cord-005453-4057qib7 15021 4 analysis analysis NN cord-005453-4057qib7 15021 5 , , , cord-005453-4057qib7 15021 6 overall overall JJ cord-005453-4057qib7 15021 7 survival survival NN cord-005453-4057qib7 15021 8 was be VBD cord-005453-4057qib7 15021 9 49 49 CD cord-005453-4057qib7 15021 10 % % NN cord-005453-4057qib7 15021 11 ( ( -LRB- cord-005453-4057qib7 15021 12 MSD MSD NNP cord-005453-4057qib7 15021 13 ) ) -RRB- cord-005453-4057qib7 15021 14 , , , cord-005453-4057qib7 15021 15 50 50 CD cord-005453-4057qib7 15021 16 % % NN cord-005453-4057qib7 15021 17 ( ( -LRB- cord-005453-4057qib7 15021 18 MUD≤25 MUD≤25 NNP cord-005453-4057qib7 15021 19 ) ) -RRB- cord-005453-4057qib7 15021 20 , , , cord-005453-4057qib7 15021 21 45 45 CD cord-005453-4057qib7 15021 22 % % NN cord-005453-4057qib7 15022 1 ( ( -LRB- cord-005453-4057qib7 15022 2 MUD mud RB cord-005453-4057qib7 15022 3 25 25 CD cord-005453-4057qib7 15022 4 - - SYM cord-005453-4057qib7 15022 5 40 40 CD cord-005453-4057qib7 15022 6 ) ) -RRB- cord-005453-4057qib7 15022 7 , , , cord-005453-4057qib7 15022 8 and and CC cord-005453-4057qib7 15022 9 43 43 CD cord-005453-4057qib7 15022 10 % % NN cord-005453-4057qib7 15022 11 ( ( -LRB- cord-005453-4057qib7 15022 12 MUD≥40 MUD≥40 NNS cord-005453-4057qib7 15022 13 , , , cord-005453-4057qib7 15022 14 p=0.002 p=0.002 NNP cord-005453-4057qib7 15022 15 ) ) -RRB- cord-005453-4057qib7 15022 16 . . . cord-005453-4057qib7 15023 1 Corresponding correspond VBG cord-005453-4057qib7 15023 2 non non JJ cord-005453-4057qib7 15023 3 - - JJ cord-005453-4057qib7 15023 4 relapse relapse JJ cord-005453-4057qib7 15023 5 mortality mortality NN cord-005453-4057qib7 15023 6 ( ( -LRB- cord-005453-4057qib7 15023 7 NRM NRM NNP cord-005453-4057qib7 15023 8 ) ) -RRB- cord-005453-4057qib7 15023 9 cumulative cumulative JJ cord-005453-4057qib7 15023 10 incidence incidence NN cord-005453-4057qib7 15023 11 was be VBD cord-005453-4057qib7 15023 12 22 22 CD cord-005453-4057qib7 15023 13 % % NN cord-005453-4057qib7 15023 14 , , , cord-005453-4057qib7 15023 15 25%.,31 25%.,31 CD cord-005453-4057qib7 15023 16 % % NN cord-005453-4057qib7 15023 17 , , , cord-005453-4057qib7 15023 18 and and CC cord-005453-4057qib7 15023 19 32.2 32.2 CD cord-005453-4057qib7 15023 20 % % NN cord-005453-4057qib7 15023 21 ( ( -LRB- cord-005453-4057qib7 15023 22 p p NN cord-005453-4057qib7 15023 23 < < XX cord-005453-4057qib7 15023 24 0.001 0.001 CD cord-005453-4057qib7 15023 25 ) ) -RRB- cord-005453-4057qib7 15024 1 ( ( -LRB- cord-005453-4057qib7 15024 2 Figure figure NN cord-005453-4057qib7 15024 3 ) ) -RRB- cord-005453-4057qib7 15024 4 . . . cord-005453-4057qib7 15025 1 GVHD gvhd NN cord-005453-4057qib7 15025 2 - - HYPH cord-005453-4057qib7 15025 3 relapse relapse NN cord-005453-4057qib7 15025 4 - - HYPH cord-005453-4057qib7 15025 5 free free JJ cord-005453-4057qib7 15025 6 ( ( -LRB- cord-005453-4057qib7 15025 7 GRFS GRFS NNP cord-005453-4057qib7 15025 8 ) ) -RRB- cord-005453-4057qib7 15025 9 was be VBD cord-005453-4057qib7 15025 10 29 29 CD cord-005453-4057qib7 15025 11 % % NN cord-005453-4057qib7 15025 12 , , , cord-005453-4057qib7 15025 13 30 30 CD cord-005453-4057qib7 15025 14 % % NN cord-005453-4057qib7 15025 15 , , , cord-005453-4057qib7 15025 16 26 26 CD cord-005453-4057qib7 15025 17 % % NN cord-005453-4057qib7 15025 18 , , , cord-005453-4057qib7 15025 19 and and CC cord-005453-4057qib7 15025 20 24 24 CD cord-005453-4057qib7 15025 21 % % NN cord-005453-4057qib7 15025 22 ( ( -LRB- cord-005453-4057qib7 15025 23 p=0.012 p=0.012 NNP cord-005453-4057qib7 15025 24 ) ) -RRB- cord-005453-4057qib7 15025 25 . . . cord-005453-4057qib7 15026 1 In in IN cord-005453-4057qib7 15026 2 a a DT cord-005453-4057qib7 15026 3 multivariable multivariable JJ cord-005453-4057qib7 15026 4 Cox Cox NNP cord-005453-4057qib7 15026 5 model model NN cord-005453-4057qib7 15026 6 , , , cord-005453-4057qib7 15026 7 young young JJ cord-005453-4057qib7 15026 8 MUD mud NN cord-005453-4057qib7 15026 9 ( ( -LRB- cord-005453-4057qib7 15026 10 ≤25 ≤25 NNP cord-005453-4057qib7 15026 11 ) ) -RRB- cord-005453-4057qib7 15026 12 had have VBD cord-005453-4057qib7 15026 13 a a DT cord-005453-4057qib7 15026 14 similar similar JJ cord-005453-4057qib7 15026 15 risk risk NN cord-005453-4057qib7 15026 16 for for IN cord-005453-4057qib7 15026 17 mortality mortality NN cord-005453-4057qib7 15026 18 compared compare VBN cord-005453-4057qib7 15026 19 to to IN cord-005453-4057qib7 15026 20 MSD MSD NNP cord-005453-4057qib7 15026 21 ( ( -LRB- cord-005453-4057qib7 15026 22 HR HR NNP cord-005453-4057qib7 15026 23 1.00 1.00 CD cord-005453-4057qib7 15026 24 , , , cord-005453-4057qib7 15026 25 p=0.97 p=0.97 NNP cord-005453-4057qib7 15026 26 ) ) -RRB- cord-005453-4057qib7 15026 27 , , , cord-005453-4057qib7 15026 28 while while IN cord-005453-4057qib7 15026 29 a a DT cord-005453-4057qib7 15026 30 monotonic monotonic JJ cord-005453-4057qib7 15026 31 increase increase NN cord-005453-4057qib7 15026 32 in in IN cord-005453-4057qib7 15026 33 risk risk NN cord-005453-4057qib7 15026 34 was be VBD cord-005453-4057qib7 15026 35 observed observe VBN cord-005453-4057qib7 15026 36 with with IN cord-005453-4057qib7 15026 37 an an DT cord-005453-4057qib7 15026 38 older old JJR cord-005453-4057qib7 15026 39 donor donor NN cord-005453-4057qib7 15026 40 age age NN cord-005453-4057qib7 15026 41 ( ( -LRB- cord-005453-4057qib7 15026 42 MUD MUD NNP cord-005453-4057qib7 15026 43 25 25 CD cord-005453-4057qib7 15026 44 - - HYPH cord-005453-4057qib7 15026 45 40y 40y CD cord-005453-4057qib7 15026 46 : : : cord-005453-4057qib7 15026 47 HR HR NNP cord-005453-4057qib7 15026 48 1.17,p=0.014 1.17,p=0.014 CD cord-005453-4057qib7 15026 49 ; ; : cord-005453-4057qib7 15026 50 MUD≥40y MUD≥40y NNP cord-005453-4057qib7 15026 51 : : : cord-005453-4057qib7 15027 1 HR HR NNP cord-005453-4057qib7 15027 2 1.26 1.26 CD cord-005453-4057qib7 15027 3 , , , cord-005453-4057qib7 15027 4 p=0.001 p=0.001 NNP cord-005453-4057qib7 15027 5 ) ) -RRB- cord-005453-4057qib7 15028 1 ( ( -LRB- cord-005453-4057qib7 15028 2 Table table NN cord-005453-4057qib7 15028 3 ) ) -RRB- cord-005453-4057qib7 15028 4 . . . cord-005453-4057qib7 15029 1 Findings finding NNS cord-005453-4057qib7 15029 2 were be VBD cord-005453-4057qib7 15029 3 confirmed confirm VBN cord-005453-4057qib7 15029 4 in in IN cord-005453-4057qib7 15029 5 a a DT cord-005453-4057qib7 15029 6 propensity propensity NN cord-005453-4057qib7 15029 7 score score NN cord-005453-4057qib7 15029 8 analysis analysis NN cord-005453-4057qib7 15029 9 , , , cord-005453-4057qib7 15029 10 matched match VBN cord-005453-4057qib7 15029 11 for for IN cord-005453-4057qib7 15029 12 key key JJ cord-005453-4057qib7 15029 13 covariates covariate NNS cord-005453-4057qib7 15029 14 . . . cord-005453-4057qib7 15030 1 NRM NRM NNP cord-005453-4057qib7 15030 2 and and CC cord-005453-4057qib7 15030 3 Grade Grade NNP cord-005453-4057qib7 15030 4 2 2 CD cord-005453-4057qib7 15030 5 - - SYM cord-005453-4057qib7 15030 6 4 4 CD cord-005453-4057qib7 15030 7 acute acute JJ cord-005453-4057qib7 15030 8 GVHD GVHD NNP cord-005453-4057qib7 15030 9 were be VBD cord-005453-4057qib7 15030 10 consistently consistently RB cord-005453-4057qib7 15030 11 higher high JJR cord-005453-4057qib7 15030 12 with with IN cord-005453-4057qib7 15030 13 MUD mud NN cord-005453-4057qib7 15030 14 , , , cord-005453-4057qib7 15030 15 with with IN cord-005453-4057qib7 15030 16 the the DT cord-005453-4057qib7 15030 17 greatest great JJS cord-005453-4057qib7 15030 18 risk risk NN cord-005453-4057qib7 15030 19 associated associate VBN cord-005453-4057qib7 15030 20 with with IN cord-005453-4057qib7 15030 21 older old JJR cord-005453-4057qib7 15030 22 MUDs mud NNS cord-005453-4057qib7 15030 23 . . . cord-005453-4057qib7 15031 1 The the DT cord-005453-4057qib7 15031 2 hazard hazard NN cord-005453-4057qib7 15031 3 for for IN cord-005453-4057qib7 15031 4 GRFS GRFS NNP cord-005453-4057qib7 15031 5 was be VBD cord-005453-4057qib7 15031 6 higher high JJR cord-005453-4057qib7 15031 7 with with IN cord-005453-4057qib7 15031 8 MUD mud NN cord-005453-4057qib7 15031 9 aged age VBN cord-005453-4057qib7 15031 10 25 25 CD cord-005453-4057qib7 15031 11 or or CC cord-005453-4057qib7 15031 12 higher high JJR cord-005453-4057qib7 15031 13 compared compare VBN cord-005453-4057qib7 15031 14 to to IN cord-005453-4057qib7 15031 15 MSD msd NN cord-005453-4057qib7 15031 16 ; ; : cord-005453-4057qib7 15031 17 risk risk NN cord-005453-4057qib7 15031 18 was be VBD cord-005453-4057qib7 15031 19 not not RB cord-005453-4057qib7 15031 20 higher high JJR cord-005453-4057qib7 15031 21 with with IN cord-005453-4057qib7 15031 22 younger young JJR cord-005453-4057qib7 15031 23 MUD mud NN cord-005453-4057qib7 15031 24 . . . cord-005453-4057qib7 15032 1 Conclusions conclusion NNS cord-005453-4057qib7 15032 2 : : : cord-005453-4057qib7 15033 1 In in IN cord-005453-4057qib7 15033 2 older old JJR cord-005453-4057qib7 15033 3 patients patient NNS cord-005453-4057qib7 15033 4 receiving receive VBG cord-005453-4057qib7 15033 5 reduced reduce VBN cord-005453-4057qib7 15033 6 intensity intensity NN cord-005453-4057qib7 15033 7 conditioning conditioning NN cord-005453-4057qib7 15033 8 , , , cord-005453-4057qib7 15033 9 MSD MSD NNP cord-005453-4057qib7 15033 10 remain remain VBP cord-005453-4057qib7 15033 11 the the DT cord-005453-4057qib7 15033 12 optimal optimal JJ cord-005453-4057qib7 15033 13 choice choice NN cord-005453-4057qib7 15033 14 . . . cord-005453-4057qib7 15034 1 However however RB cord-005453-4057qib7 15034 2 , , , cord-005453-4057qib7 15034 3 when when WRB cord-005453-4057qib7 15034 4 not not RB cord-005453-4057qib7 15034 5 available available JJ cord-005453-4057qib7 15034 6 , , , cord-005453-4057qib7 15034 7 young young JJ cord-005453-4057qib7 15034 8 MUD MUD NNP cord-005453-4057qib7 15034 9 provide provide VBP cord-005453-4057qib7 15034 10 comparable comparable JJ cord-005453-4057qib7 15034 11 results result NNS cord-005453-4057qib7 15034 12 . . . cord-005453-4057qib7 15035 1 Disclosure disclosure NN cord-005453-4057qib7 15035 2 : : : cord-005453-4057qib7 15035 3 Nothing nothing NN cord-005453-4057qib7 15035 4 to to TO cord-005453-4057qib7 15035 5 declare declare VB cord-005453-4057qib7 15035 6 Background Background NNP cord-005453-4057qib7 15035 7 : : : cord-005453-4057qib7 15035 8 There there EX cord-005453-4057qib7 15035 9 is be VBZ cord-005453-4057qib7 15035 10 growing grow VBG cord-005453-4057qib7 15035 11 evidence evidence NN cord-005453-4057qib7 15035 12 that that IN cord-005453-4057qib7 15035 13 community community NN cord-005453-4057qib7 15035 14 acquired acquire VBD cord-005453-4057qib7 15035 15 respiratory respiratory JJ cord-005453-4057qib7 15035 16 virus virus NN cord-005453-4057qib7 15035 17 ( ( -LRB- cord-005453-4057qib7 15035 18 CARV CARV NNP cord-005453-4057qib7 15035 19 ) ) -RRB- cord-005453-4057qib7 15035 20 increase increase VB cord-005453-4057qib7 15035 21 the the DT cord-005453-4057qib7 15035 22 risk risk NN cord-005453-4057qib7 15035 23 of of IN cord-005453-4057qib7 15035 24 pulmonary pulmonary JJ cord-005453-4057qib7 15035 25 invasive invasive JJ cord-005453-4057qib7 15035 26 fungal fungal NN cord-005453-4057qib7 15035 27 disease disease NN cord-005453-4057qib7 15035 28 ( ( -LRB- cord-005453-4057qib7 15035 29 IFD IFD NNP cord-005453-4057qib7 15035 30 ) ) -RRB- cord-005453-4057qib7 15035 31 in in IN cord-005453-4057qib7 15035 32 recipients recipient NNS cord-005453-4057qib7 15035 33 of of IN cord-005453-4057qib7 15035 34 allogeneic allogeneic JJ cord-005453-4057qib7 15035 35 hematopoietic hematopoietic JJ cord-005453-4057qib7 15035 36 stem stem NN cord-005453-4057qib7 15035 37 cell cell NN cord-005453-4057qib7 15035 38 transplantation transplantation NN cord-005453-4057qib7 15035 39 ( ( -LRB- cord-005453-4057qib7 15035 40 allo allo NN cord-005453-4057qib7 15035 41 - - HYPH cord-005453-4057qib7 15035 42 HSCT HSCT NNP cord-005453-4057qib7 15035 43 ) ) -RRB- cord-005453-4057qib7 15035 44 . . . cord-005453-4057qib7 15036 1 To to IN cord-005453-4057qib7 15036 2 date date NN cord-005453-4057qib7 15036 3 , , , cord-005453-4057qib7 15036 4 there there EX cord-005453-4057qib7 15036 5 is be VBZ cord-005453-4057qib7 15036 6 a a DT cord-005453-4057qib7 15036 7 lack lack NN cord-005453-4057qib7 15036 8 of of IN cord-005453-4057qib7 15036 9 knowledge knowledge NN cord-005453-4057qib7 15036 10 regarding regard VBG cord-005453-4057qib7 15036 11 the the DT cord-005453-4057qib7 15036 12 rate rate NN cord-005453-4057qib7 15036 13 of of IN cord-005453-4057qib7 15036 14 IFD IFD NNP cord-005453-4057qib7 15036 15 , , , cord-005453-4057qib7 15036 16 risk risk NN cord-005453-4057qib7 15036 17 factors factor NNS cord-005453-4057qib7 15036 18 ( ( -LRB- cord-005453-4057qib7 15036 19 RFs RFs NNP cord-005453-4057qib7 15036 20 ) ) -RRB- cord-005453-4057qib7 15036 21 as as RB cord-005453-4057qib7 15036 22 well well RB cord-005453-4057qib7 15036 23 as as IN cord-005453-4057qib7 15036 24 the the DT cord-005453-4057qib7 15036 25 most most RBS cord-005453-4057qib7 15036 26 critical critical JJ cord-005453-4057qib7 15036 27 period period NN cord-005453-4057qib7 15036 28 for for IN cord-005453-4057qib7 15036 29 the the DT cord-005453-4057qib7 15036 30 development development NN cord-005453-4057qib7 15036 31 of of IN cord-005453-4057qib7 15036 32 a a DT cord-005453-4057qib7 15036 33 later later JJ cord-005453-4057qib7 15036 34 IFD IFD NNP cord-005453-4057qib7 15036 35 after after IN cord-005453-4057qib7 15036 36 CARV CARV NNP cord-005453-4057qib7 15036 37 infections infection NNS cord-005453-4057qib7 15036 38 in in IN cord-005453-4057qib7 15036 39 allo allo NN cord-005453-4057qib7 15036 40 - - HYPH cord-005453-4057qib7 15036 41 HSCT HSCT NNP cord-005453-4057qib7 15036 42 recipients recipient NNS cord-005453-4057qib7 15036 43 . . . cord-005453-4057qib7 15037 1 Methods method NNS cord-005453-4057qib7 15037 2 : : : cord-005453-4057qib7 15037 3 In in IN cord-005453-4057qib7 15037 4 this this DT cord-005453-4057qib7 15037 5 prospective prospective JJ cord-005453-4057qib7 15037 6 observational observational JJ cord-005453-4057qib7 15037 7 study study NN cord-005453-4057qib7 15037 8 , , , cord-005453-4057qib7 15037 9 we -PRON- PRP cord-005453-4057qib7 15037 10 retrospectively retrospectively RB cord-005453-4057qib7 15037 11 analyzed analyze VBD cord-005453-4057qib7 15037 12 the the DT cord-005453-4057qib7 15037 13 effect effect NN cord-005453-4057qib7 15037 14 of of IN cord-005453-4057qib7 15037 15 CARV CARV NNP cord-005453-4057qib7 15037 16 on on IN cord-005453-4057qib7 15037 17 the the DT cord-005453-4057qib7 15037 18 development development NN cord-005453-4057qib7 15037 19 of of IN cord-005453-4057qib7 15037 20 a a DT cord-005453-4057qib7 15037 21 later later JJ cord-005453-4057qib7 15037 22 IFD ifd NN cord-005453-4057qib7 15037 23 in in IN cord-005453-4057qib7 15037 24 a a DT cord-005453-4057qib7 15037 25 consecutive consecutive JJ cord-005453-4057qib7 15037 26 cohort cohort NN cord-005453-4057qib7 15037 27 of of IN cord-005453-4057qib7 15037 28 287 287 CD cord-005453-4057qib7 15037 29 allo allo NN cord-005453-4057qib7 15037 30 - - HYPH cord-005453-4057qib7 15037 31 HSCT HSCT NNP cord-005453-4057qib7 15037 32 adult adult NN cord-005453-4057qib7 15037 33 recipients recipient NNS cord-005453-4057qib7 15037 34 who who WP cord-005453-4057qib7 15037 35 developed develop VBD cord-005453-4057qib7 15037 36 597 597 CD cord-005453-4057qib7 15037 37 CARV CARV NNP cord-005453-4057qib7 15037 38 infectious infectious JJ cord-005453-4057qib7 15037 39 episodes episode NNS cord-005453-4057qib7 15037 40 from from IN cord-005453-4057qib7 15037 41 December December NNP cord-005453-4057qib7 15037 42 2013 2013 CD cord-005453-4057qib7 15037 43 to to IN cord-005453-4057qib7 15037 44 December December NNP cord-005453-4057qib7 15037 45 2018 2018 CD cord-005453-4057qib7 15037 46 . . . cord-005453-4057qib7 15038 1 Respiratory respiratory JJ cord-005453-4057qib7 15038 2 virus virus NN cord-005453-4057qib7 15038 3 in in IN cord-005453-4057qib7 15038 4 upper upper JJ cord-005453-4057qib7 15038 5 and/or and/or CC cord-005453-4057qib7 15039 1 lower low JJR cord-005453-4057qib7 15039 2 respiratory respiratory JJ cord-005453-4057qib7 15039 3 tract tract NN cord-005453-4057qib7 15039 4 specimens specimen NNS cord-005453-4057qib7 15039 5 were be VBD cord-005453-4057qib7 15039 6 tested test VBN cord-005453-4057qib7 15039 7 using use VBG cord-005453-4057qib7 15039 8 multiplex multiplex JJ cord-005453-4057qib7 15039 9 PCR PCR NNP cord-005453-4057qib7 15039 10 panel panel NN cord-005453-4057qib7 15039 11 assays assay NNS cord-005453-4057qib7 15039 12 . . . cord-005453-4057qib7 15040 1 Results result NNS cord-005453-4057qib7 15040 2 : : : cord-005453-4057qib7 15040 3 Overall overall RB cord-005453-4057qib7 15040 4 , , , cord-005453-4057qib7 15040 5 29 29 CD cord-005453-4057qib7 15040 6 out out IN cord-005453-4057qib7 15040 7 of of IN cord-005453-4057qib7 15040 8 287 287 CD cord-005453-4057qib7 15040 9 allo allo NN cord-005453-4057qib7 15040 10 - - HYPH cord-005453-4057qib7 15040 11 HSCT HSCT NNP cord-005453-4057qib7 15040 12 recipients recipient NNS cord-005453-4057qib7 15040 13 ( ( -LRB- cord-005453-4057qib7 15040 14 10 10 CD cord-005453-4057qib7 15040 15 % % NN cord-005453-4057qib7 15040 16 ) ) -RRB- cord-005453-4057qib7 15040 17 developed develop VBD cord-005453-4057qib7 15040 18 IFD IFD NNP cord-005453-4057qib7 15040 19 within within IN cord-005453-4057qib7 15040 20 2 2 CD cord-005453-4057qib7 15040 21 months month NNS cord-005453-4057qib7 15040 22 after after IN cord-005453-4057qib7 15040 23 a a DT cord-005453-4057qib7 15040 24 CARV CARV NNP cord-005453-4057qib7 15040 25 episode episode NN cord-005453-4057qib7 15040 26 at at IN cord-005453-4057qib7 15040 27 median median NN cord-005453-4057qib7 15040 28 of of IN cord-005453-4057qib7 15040 29 21 21 CD cord-005453-4057qib7 15040 30 days day NNS cord-005453-4057qib7 15041 1 ( ( -LRB- cord-005453-4057qib7 15041 2 range range NN cord-005453-4057qib7 15041 3 0 0 CD cord-005453-4057qib7 15041 4 - - SYM cord-005453-4057qib7 15041 5 158 158 CD cord-005453-4057qib7 15041 6 days day NNS cord-005453-4057qib7 15041 7 ) ) -RRB- cord-005453-4057qib7 15041 8 from from IN cord-005453-4057qib7 15041 9 the the DT cord-005453-4057qib7 15041 10 day day NN cord-005453-4057qib7 15041 11 of of IN cord-005453-4057qib7 15041 12 CARV CARV NNP cord-005453-4057qib7 15041 13 detection detection NN cord-005453-4057qib7 15041 14 . . . cord-005453-4057qib7 15042 1 All all PDT cord-005453-4057qib7 15042 2 the the DT cord-005453-4057qib7 15042 3 IFDs ifd NNS cord-005453-4057qib7 15042 4 involved involve VBD cord-005453-4057qib7 15042 5 the the DT cord-005453-4057qib7 15042 6 lungs lung NNS cord-005453-4057qib7 15042 7 and and CC cord-005453-4057qib7 15042 8 in in IN cord-005453-4057qib7 15042 9 28 28 CD cord-005453-4057qib7 15042 10 cases case NNS cord-005453-4057qib7 15042 11 ( ( -LRB- cord-005453-4057qib7 15042 12 97 97 CD cord-005453-4057qib7 15042 13 % % NN cord-005453-4057qib7 15042 14 ) ) -RRB- cord-005453-4057qib7 15043 1 the the DT cord-005453-4057qib7 15043 2 diagnostic diagnostic NN cord-005453-4057qib7 15043 3 was be VBD cord-005453-4057qib7 15044 1 IA IA NNP cord-005453-4057qib7 15044 2 accomplishing accomplish VBG cord-005453-4057qib7 15044 3 criteria criterion NNS cord-005453-4057qib7 15044 4 of of IN cord-005453-4057qib7 15044 5 probable probable JJ cord-005453-4057qib7 15044 6 ( ( -LRB- cord-005453-4057qib7 15044 7 n= n= NNP cord-005453-4057qib7 15044 8 26 26 CD cord-005453-4057qib7 15044 9 ) ) -RRB- cord-005453-4057qib7 15044 10 or or CC cord-005453-4057qib7 15044 11 proven prove VBN cord-005453-4057qib7 15044 12 ( ( -LRB- cord-005453-4057qib7 15044 13 n=2 n=2 NNS cord-005453-4057qib7 15044 14 ) ) -RRB- cord-005453-4057qib7 15044 15 . . . cord-005453-4057qib7 15045 1 Of of IN cord-005453-4057qib7 15045 2 note note NN cord-005453-4057qib7 15045 3 , , , cord-005453-4057qib7 15045 4 26 26 CD cord-005453-4057qib7 15045 5 out out IN cord-005453-4057qib7 15045 6 of of IN cord-005453-4057qib7 15045 7 29 29 CD cord-005453-4057qib7 15045 8 IFD IFD NNP cord-005453-4057qib7 15045 9 ( ( -LRB- cord-005453-4057qib7 15045 10 91 91 CD cord-005453-4057qib7 15045 11 % % NN cord-005453-4057qib7 15045 12 ) ) -RRB- cord-005453-4057qib7 15045 13 occurred occur VBD cord-005453-4057qib7 15045 14 within within IN cord-005453-4057qib7 15045 15 the the DT cord-005453-4057qib7 15045 16 first first JJ cord-005453-4057qib7 15045 17 year year NN cord-005453-4057qib7 15045 18 after after IN cord-005453-4057qib7 15045 19 transplantation transplantation NN cord-005453-4057qib7 15045 20 . . . cord-005453-4057qib7 15046 1 The the DT cord-005453-4057qib7 15046 2 overall overall JJ cord-005453-4057qib7 15046 3 rate rate NN cord-005453-4057qib7 15046 4 of of IN cord-005453-4057qib7 15046 5 IFD IFD NNP cord-005453-4057qib7 15046 6 after after IN cord-005453-4057qib7 15046 7 CARV CARV NNP cord-005453-4057qib7 15046 8 episodes episode NNS cord-005453-4057qib7 15046 9 was be VBD cord-005453-4057qib7 15046 10 5 5 CD cord-005453-4057qib7 15046 11 % % NN cord-005453-4057qib7 15046 12 whereas whereas IN cord-005453-4057qib7 15046 13 this this DT cord-005453-4057qib7 15046 14 rate rate NN cord-005453-4057qib7 15046 15 was be VBD cord-005453-4057qib7 15046 16 higher high JJR cord-005453-4057qib7 15046 17 in in IN cord-005453-4057qib7 15046 18 recipients recipient NNS cord-005453-4057qib7 15046 19 developing develop VBG cord-005453-4057qib7 15046 20 CARV CARV NNP cord-005453-4057qib7 15046 21 during during IN cord-005453-4057qib7 15046 22 the the DT cord-005453-4057qib7 15046 23 first first JJ cord-005453-4057qib7 15046 24 year year NN cord-005453-4057qib7 15046 25 of of IN cord-005453-4057qib7 15046 26 transplant transplant NN cord-005453-4057qib7 15046 27 ( ( -LRB- cord-005453-4057qib7 15046 28 7 7 CD cord-005453-4057qib7 15046 29 % % NN cord-005453-4057qib7 15046 30 ) ) -RRB- cord-005453-4057qib7 15046 31 . . . cord-005453-4057qib7 15047 1 IFD IFD NNP cord-005453-4057qib7 15047 2 was be VBD cord-005453-4057qib7 15047 3 diagnosed diagnose VBN cord-005453-4057qib7 15047 4 in in IN cord-005453-4057qib7 15047 5 25 25 CD cord-005453-4057qib7 15047 6 out out IN cord-005453-4057qib7 15047 7 of of IN cord-005453-4057qib7 15047 8 203 203 CD cord-005453-4057qib7 15047 9 with with IN cord-005453-4057qib7 15047 10 CARV CARV NNP cord-005453-4057qib7 15047 11 lower low JJR cord-005453-4057qib7 15047 12 respiratory respiratory JJ cord-005453-4057qib7 15047 13 tract tract NN cord-005453-4057qib7 15047 14 disease disease NN cord-005453-4057qib7 15047 15 ( ( -LRB- cord-005453-4057qib7 15047 16 LRTD LRTD NNP cord-005453-4057qib7 15047 17 ) ) -RRB- cord-005453-4057qib7 15047 18 episodes episode NNS cord-005453-4057qib7 15047 19 ( ( -LRB- cord-005453-4057qib7 15047 20 12 12 CD cord-005453-4057qib7 15047 21 % % NN cord-005453-4057qib7 15047 22 ) ) -RRB- cord-005453-4057qib7 15047 23 compared compare VBN cord-005453-4057qib7 15047 24 to to IN cord-005453-4057qib7 15047 25 4 4 CD cord-005453-4057qib7 15047 26 out out IN cord-005453-4057qib7 15047 27 of of IN cord-005453-4057qib7 15047 28 394 394 CD cord-005453-4057qib7 15047 29 CARV CARV NNP cord-005453-4057qib7 15047 30 upper upper JJ cord-005453-4057qib7 15047 31 respiratory respiratory JJ cord-005453-4057qib7 15047 32 tract tract NN cord-005453-4057qib7 15047 33 disease disease NN cord-005453-4057qib7 15047 34 ( ( -LRB- cord-005453-4057qib7 15047 35 URTD URTD NNP cord-005453-4057qib7 15047 36 ) ) -RRB- cord-005453-4057qib7 15047 37 ( ( -LRB- cord-005453-4057qib7 15047 38 1 1 CD cord-005453-4057qib7 15047 39 % % NN cord-005453-4057qib7 15047 40 ) ) -RRB- cord-005453-4057qib7 15047 41 ( ( -LRB- cord-005453-4057qib7 15047 42 p= p= NNP cord-005453-4057qib7 15047 43 0.0001 0.0001 CD cord-005453-4057qib7 15047 44 ) ) -RRB- cord-005453-4057qib7 15047 45 . . . cord-005453-4057qib7 15048 1 Twenty twenty CD cord-005453-4057qib7 15048 2 - - HYPH cord-005453-4057qib7 15048 3 three three CD cord-005453-4057qib7 15048 4 out out IN cord-005453-4057qib7 15048 5 of of IN cord-005453-4057qib7 15048 6 133 133 CD cord-005453-4057qib7 15048 7 CARV CARV NNP cord-005453-4057qib7 15048 8 episodes episode NNS cord-005453-4057qib7 15048 9 involving involve VBG cord-005453-4057qib7 15048 10 the the DT cord-005453-4057qib7 15048 11 LRTD LRTD NNP cord-005453-4057qib7 15048 12 during during IN cord-005453-4057qib7 15048 13 the the DT cord-005453-4057qib7 15048 14 first first JJ cord-005453-4057qib7 15048 15 year year NN cord-005453-4057qib7 15048 16 after after IN cord-005453-4057qib7 15048 17 transplant transplant NN cord-005453-4057qib7 15048 18 ( ( -LRB- cord-005453-4057qib7 15048 19 17 17 CD cord-005453-4057qib7 15048 20 % % NN cord-005453-4057qib7 15048 21 ) ) -RRB- cord-005453-4057qib7 15048 22 developed develop VBD cord-005453-4057qib7 15048 23 IFD IFD NNP cord-005453-4057qib7 15048 24 . . . cord-005453-4057qib7 15049 1 We -PRON- PRP cord-005453-4057qib7 15049 2 did do VBD cord-005453-4057qib7 15049 3 not not RB cord-005453-4057qib7 15049 4 found find VBD cord-005453-4057qib7 15049 5 differences difference NNS cord-005453-4057qib7 15049 6 in in IN cord-005453-4057qib7 15049 7 IFD IFD NNP cord-005453-4057qib7 15049 8 rates rate NNS cord-005453-4057qib7 15049 9 according accord VBG cord-005453-4057qib7 15049 10 to to IN cord-005453-4057qib7 15049 11 the the DT cord-005453-4057qib7 15049 12 type type NN cord-005453-4057qib7 15049 13 of of IN cord-005453-4057qib7 15049 14 CARV CARV NNP cord-005453-4057qib7 15049 15 identified identify VBN cord-005453-4057qib7 15049 16 . . . cord-005453-4057qib7 15050 1 Multivariate multivariate JJ cord-005453-4057qib7 15050 2 analysis analysis NN cord-005453-4057qib7 15050 3 identified identify VBD cord-005453-4057qib7 15050 4 4 4 CD cord-005453-4057qib7 15050 5 RFs rf NNS cord-005453-4057qib7 15050 6 for for IN cord-005453-4057qib7 15050 7 IFD IFD NNP cord-005453-4057qib7 15050 8 : : : cord-005453-4057qib7 15050 9 the the DT cord-005453-4057qib7 15050 10 use use NN cord-005453-4057qib7 15050 11 of of IN cord-005453-4057qib7 15050 12 ATG ATG NNP cord-005453-4057qib7 15050 13 as as IN cord-005453-4057qib7 15050 14 a a DT cord-005453-4057qib7 15050 15 part part NN cord-005453-4057qib7 15050 16 of of IN cord-005453-4057qib7 15050 17 conditioning conditioning NN cord-005453-4057qib7 15050 18 [ [ -LRB- cord-005453-4057qib7 15050 19 odds odd NNS cord-005453-4057qib7 15050 20 ratio ratio NN cord-005453-4057qib7 15050 21 ( ( -LRB- cord-005453-4057qib7 15050 22 OR OR NNP cord-005453-4057qib7 15050 23 ) ) -RRB- cord-005453-4057qib7 15050 24 2.7 2.7 CD cord-005453-4057qib7 15050 25 , , , cord-005453-4057qib7 15050 26 95 95 CD cord-005453-4057qib7 15050 27 % % NN cord-005453-4057qib7 15050 28 confidence confidence NN cord-005453-4057qib7 15050 29 interval interval NN cord-005453-4057qib7 15050 30 ( ( -LRB- cord-005453-4057qib7 15050 31 C.I. C.I. NNP cord-005453-4057qib7 15050 32 ) ) -RRB- cord-005453-4057qib7 15050 33 1.2 1.2 CD cord-005453-4057qib7 15050 34 - - SYM cord-005453-4057qib7 15050 35 3.4 3.4 CD cord-005453-4057qib7 15050 36 , , , cord-005453-4057qib7 15050 37 p= p= NN cord-005453-4057qib7 15050 38 0.01 0.01 CD cord-005453-4057qib7 15050 39 ] ] -RRB- cord-005453-4057qib7 15050 40 , , , cord-005453-4057qib7 15050 41 CARV CARV NNP cord-005453-4057qib7 15050 42 LRTD LRTD NNP cord-005453-4057qib7 15050 43 ( ( -LRB- cord-005453-4057qib7 15050 44 OR or CC cord-005453-4057qib7 15050 45 11.8 11.8 CD cord-005453-4057qib7 15051 1 , , , cord-005453-4057qib7 15051 2 95 95 CD cord-005453-4057qib7 15051 3 % % NN cord-005453-4057qib7 15051 4 C.I. C.I. NNP cord-005453-4057qib7 15051 5 3.8 3.8 CD cord-005453-4057qib7 15051 6 - - SYM cord-005453-4057qib7 15051 7 36 36 CD cord-005453-4057qib7 15051 8 , , , cord-005453-4057qib7 15051 9 p= p= JJ cord-005453-4057qib7 15051 10 0.0001 0.0001 CD cord-005453-4057qib7 15051 11 ) ) -RRB- cord-005453-4057qib7 15051 12 , , , cord-005453-4057qib7 15051 13 CARV CARV NNP cord-005453-4057qib7 15051 14 infection infection NN cord-005453-4057qib7 15051 15 during during IN cord-005453-4057qib7 15051 16 the the DT cord-005453-4057qib7 15051 17 first first JJ cord-005453-4057qib7 15051 18 year year NN cord-005453-4057qib7 15051 19 of of IN cord-005453-4057qib7 15051 20 transplant transplant NN cord-005453-4057qib7 15051 21 ( ( -LRB- cord-005453-4057qib7 15051 22 OR or CC cord-005453-4057qib7 15051 23 5.9 5.9 CD cord-005453-4057qib7 15051 24 , , , cord-005453-4057qib7 15051 25 P731 p731 CD cord-005453-4057qib7 15051 26 Natural natural JJ cord-005453-4057qib7 15051 27 killer killer NN cord-005453-4057qib7 15051 28 cell cell NN cord-005453-4057qib7 15051 29 alloreactive alloreactive NNP cord-005453-4057qib7 15051 30 haploidentical haploidentical JJ cord-005453-4057qib7 15051 31 stem stem NN cord-005453-4057qib7 15051 32 cell cell NN cord-005453-4057qib7 15051 33 transplantation transplantation NN cord-005453-4057qib7 15051 34 for for IN cord-005453-4057qib7 15051 35 multiple multiple JJ cord-005453-4057qib7 15051 36 myeloma myeloma NN cord-005453-4057qib7 15051 37 patients patient NNS cord-005453-4057qib7 15051 38 Catharina Catharina NNP cord-005453-4057qib7 15051 39 Elssen Elssen NNP cord-005453-4057qib7 15051 40 1 1 CD cord-005453-4057qib7 15051 41 , , , cord-005453-4057qib7 15051 42 Lotte Lotte NNP cord-005453-4057qib7 15051 43 Wieten Wieten NNP cord-005453-4057qib7 15051 44 1 1 CD cord-005453-4057qib7 15051 45 , , , cord-005453-4057qib7 15051 46 Peter Peter NNP cord-005453-4057qib7 15051 47 Von Von NNP cord-005453-4057qib7 15051 48 dem dem VB cord-005453-4057qib7 15051 49 Borne Borne NNP cord-005453-4057qib7 15051 50 2 2 CD cord-005453-4057qib7 15051 51 , , , cord-005453-4057qib7 15051 52 Ellen Ellen NNP cord-005453-4057qib7 15051 53 Meijer Meijer NNP cord-005453-4057qib7 15051 54 3 3 CD cord-005453-4057qib7 15051 55 , , , cord-005453-4057qib7 15051 56 Gerard Gerard NNP cord-005453-4057qib7 15051 57 Bos Bos NNP cord-005453-4057qib7 15051 58 1 1 CD cord-005453-4057qib7 15051 59 1 1 CD cord-005453-4057qib7 15051 60 Maastricht Maastricht NNP cord-005453-4057qib7 15051 61 University University NNP cord-005453-4057qib7 15051 62 Medical Medical NNP cord-005453-4057qib7 15051 63 Center Center NNP cord-005453-4057qib7 15051 64 , , , cord-005453-4057qib7 15051 65 Maastricht Maastricht NNP cord-005453-4057qib7 15051 66 , , , cord-005453-4057qib7 15051 67 Netherlands Netherlands NNP cord-005453-4057qib7 15051 68 , , , cord-005453-4057qib7 15051 69 2 2 CD cord-005453-4057qib7 15051 70 Leiden Leiden NNP cord-005453-4057qib7 15051 71 University University NNP cord-005453-4057qib7 15051 72 Medical Medical NNP cord-005453-4057qib7 15051 73 Center Center NNP cord-005453-4057qib7 15051 74 , , , cord-005453-4057qib7 15051 75 Leiden Leiden NNP cord-005453-4057qib7 15051 76 , , , cord-005453-4057qib7 15051 77 Netherlands Netherlands NNP cord-005453-4057qib7 15051 78 , , , cord-005453-4057qib7 15051 79 3 3 CD cord-005453-4057qib7 15051 80 Amsterdam Amsterdam NNP cord-005453-4057qib7 15051 81 University University NNP cord-005453-4057qib7 15051 82 Medical Medical NNP cord-005453-4057qib7 15051 83 Center Center NNP cord-005453-4057qib7 15051 84 , , , cord-005453-4057qib7 15051 85 Location Location NNP cord-005453-4057qib7 15051 86 VUMC VUMC NNP cord-005453-4057qib7 15051 87 , , , cord-005453-4057qib7 15051 88 Cancer Cancer NNP cord-005453-4057qib7 15051 89 Center Center NNP cord-005453-4057qib7 15051 90 , , , cord-005453-4057qib7 15051 91 Amsterdam Amsterdam NNP cord-005453-4057qib7 15051 92 , , , cord-005453-4057qib7 15052 1 Netherlands Netherlands NNP cord-005453-4057qib7 15052 2 Background Background NNP cord-005453-4057qib7 15052 3 : : : cord-005453-4057qib7 15053 1 In in IN cord-005453-4057qib7 15053 2 the the DT cord-005453-4057qib7 15053 3 past past JJ cord-005453-4057qib7 15053 4 years year NNS cord-005453-4057qib7 15053 5 many many JJ cord-005453-4057qib7 15053 6 new new JJ cord-005453-4057qib7 15053 7 drugs drug NNS cord-005453-4057qib7 15053 8 for for IN cord-005453-4057qib7 15053 9 Multiple multiple JJ cord-005453-4057qib7 15053 10 myeloma myeloma NN cord-005453-4057qib7 15053 11 ( ( -LRB- cord-005453-4057qib7 15053 12 MM MM NNP cord-005453-4057qib7 15053 13 ) ) -RRB- cord-005453-4057qib7 15053 14 have have VBP cord-005453-4057qib7 15053 15 been be VBN cord-005453-4057qib7 15053 16 developed develop VBN cord-005453-4057qib7 15053 17 and and CC cord-005453-4057qib7 15053 18 are be VBP cord-005453-4057qib7 15053 19 responsible responsible JJ cord-005453-4057qib7 15053 20 for for IN cord-005453-4057qib7 15053 21 a a DT cord-005453-4057qib7 15053 22 increase increase NN cord-005453-4057qib7 15053 23 in in IN cord-005453-4057qib7 15053 24 survival survival NN cord-005453-4057qib7 15053 25 . . . cord-005453-4057qib7 15054 1 Notwithstanding notwithstanding IN cord-005453-4057qib7 15054 2 such such JJ cord-005453-4057qib7 15054 3 progress progress NN cord-005453-4057qib7 15054 4 , , , cord-005453-4057qib7 15054 5 MM MM NNP cord-005453-4057qib7 15054 6 remains remain VBZ cord-005453-4057qib7 15054 7 incurable incurable JJ cord-005453-4057qib7 15054 8 . . . cord-005453-4057qib7 15055 1 Results result NNS cord-005453-4057qib7 15055 2 from from IN cord-005453-4057qib7 15055 3 allogeneic allogeneic JJ cord-005453-4057qib7 15055 4 stem stem NN cord-005453-4057qib7 15055 5 cell cell NN cord-005453-4057qib7 15055 6 transplantation transplantation NN cord-005453-4057qib7 15055 7 ( ( -LRB- cord-005453-4057qib7 15055 8 SCT SCT NNP cord-005453-4057qib7 15055 9 ) ) -RRB- cord-005453-4057qib7 15055 10 , , , cord-005453-4057qib7 15055 11 including include VBG cord-005453-4057qib7 15055 12 haploidentical haploidentical JJ cord-005453-4057qib7 15055 13 transplantation transplantation NN cord-005453-4057qib7 15055 14 , , , cord-005453-4057qib7 15055 15 in in IN cord-005453-4057qib7 15055 16 MM MM NNP cord-005453-4057qib7 15055 17 has have VBZ cord-005453-4057qib7 15055 18 shown show VBN cord-005453-4057qib7 15055 19 clinical clinical JJ cord-005453-4057qib7 15055 20 results result NNS cord-005453-4057qib7 15055 21 . . . cord-005453-4057qib7 15056 1 However however RB cord-005453-4057qib7 15056 2 , , , cord-005453-4057qib7 15056 3 these these DT cord-005453-4057qib7 15056 4 responses response NNS cord-005453-4057qib7 15056 5 are be VBP cord-005453-4057qib7 15056 6 only only RB cord-005453-4057qib7 15056 7 observed observe VBN cord-005453-4057qib7 15056 8 in in IN cord-005453-4057qib7 15056 9 a a DT cord-005453-4057qib7 15056 10 minority minority NN cord-005453-4057qib7 15056 11 of of IN cord-005453-4057qib7 15056 12 patients patient NNS cord-005453-4057qib7 15056 13 . . . cord-005453-4057qib7 15057 1 We -PRON- PRP cord-005453-4057qib7 15057 2 hypothesize hypothesize VBP cord-005453-4057qib7 15057 3 that that IN cord-005453-4057qib7 15057 4 this this DT cord-005453-4057qib7 15057 5 observation observation NN cord-005453-4057qib7 15057 6 might may MD cord-005453-4057qib7 15057 7 be be VB cord-005453-4057qib7 15057 8 due due JJ cord-005453-4057qib7 15057 9 to to IN cord-005453-4057qib7 15057 10 differences difference NNS cord-005453-4057qib7 15057 11 in in IN cord-005453-4057qib7 15057 12 natural natural JJ cord-005453-4057qib7 15057 13 killer killer NN cord-005453-4057qib7 15057 14 ( ( -LRB- cord-005453-4057qib7 15057 15 NK NK NNP cord-005453-4057qib7 15057 16 ) ) -RRB- cord-005453-4057qib7 15057 17 cell cell NN cord-005453-4057qib7 15057 18 alloreacitvity alloreacitvity NN cord-005453-4057qib7 15057 19 , , , cord-005453-4057qib7 15057 20 since since IN cord-005453-4057qib7 15057 21 we -PRON- PRP cord-005453-4057qib7 15057 22 have have VBP cord-005453-4057qib7 15057 23 shown show VBN cord-005453-4057qib7 15057 24 in in RP cord-005453-4057qib7 15057 25 in in IN cord-005453-4057qib7 15057 26 vivo vivo NN cord-005453-4057qib7 15057 27 and and CC cord-005453-4057qib7 15057 28 in in IN cord-005453-4057qib7 15057 29 vitro vitro FW cord-005453-4057qib7 15057 30 models model NNS cord-005453-4057qib7 15057 31 that that WDT cord-005453-4057qib7 15057 32 mismatched mismatch VBD cord-005453-4057qib7 15057 33 alloreactive alloreactive JJ cord-005453-4057qib7 15057 34 NK NK NNP cord-005453-4057qib7 15057 35 cells cell NNS cord-005453-4057qib7 15057 36 hold hold VBP cord-005453-4057qib7 15057 37 the the DT cord-005453-4057qib7 15057 38 capacity capacity NN cord-005453-4057qib7 15057 39 to to TO cord-005453-4057qib7 15057 40 kill kill VB cord-005453-4057qib7 15057 41 MM MM NNP cord-005453-4057qib7 15057 42 cells cell NNS cord-005453-4057qib7 15057 43 . . . cord-005453-4057qib7 15058 1 The the DT cord-005453-4057qib7 15058 2 aim aim NN cord-005453-4057qib7 15058 3 of of IN cord-005453-4057qib7 15058 4 this this DT cord-005453-4057qib7 15058 5 prospective prospective JJ cord-005453-4057qib7 15058 6 phase phase NN cord-005453-4057qib7 15058 7 2 2 CD cord-005453-4057qib7 15058 8 study study NN cord-005453-4057qib7 15058 9 is be VBZ cord-005453-4057qib7 15058 10 to to TO cord-005453-4057qib7 15058 11 evaluate evaluate VB cord-005453-4057qib7 15058 12 if if IN cord-005453-4057qib7 15058 13 KIR KIR NNP cord-005453-4057qib7 15058 14 - - HYPH cord-005453-4057qib7 15058 15 ligand ligand NN cord-005453-4057qib7 15058 16 mismatched mismatch VBD cord-005453-4057qib7 15058 17 haploindentical haploindentical NN cord-005453-4057qib7 15058 18 bone bone NN cord-005453-4057qib7 15058 19 marrow marrow NN cord-005453-4057qib7 15058 20 transplantation transplantation NN cord-005453-4057qib7 15058 21 ( ( -LRB- cord-005453-4057qib7 15058 22 BMT BMT NNP cord-005453-4057qib7 15058 23 ) ) -RRB- cord-005453-4057qib7 15058 24 with with IN cord-005453-4057qib7 15058 25 post post JJ cord-005453-4057qib7 15058 26 - - JJ cord-005453-4057qib7 15058 27 transplant transplant NN cord-005453-4057qib7 15058 28 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 15058 29 will will MD cord-005453-4057qib7 15058 30 improve improve VB cord-005453-4057qib7 15058 31 progression progression NN cord-005453-4057qib7 15058 32 free free JJ cord-005453-4057qib7 15058 33 survival survival NN cord-005453-4057qib7 15058 34 ( ( -LRB- cord-005453-4057qib7 15058 35 PFS PFS NNP cord-005453-4057qib7 15058 36 ) ) -RRB- cord-005453-4057qib7 15058 37 in in IN cord-005453-4057qib7 15058 38 poor poor JJ cord-005453-4057qib7 15058 39 risk risk NN cord-005453-4057qib7 15058 40 MM MM NNP cord-005453-4057qib7 15058 41 patients patient NNS cord-005453-4057qib7 15058 42 . . . cord-005453-4057qib7 15059 1 Methods method NNS cord-005453-4057qib7 15059 2 : : : cord-005453-4057qib7 15059 3 Poor poor JJ cord-005453-4057qib7 15059 4 risk risk NN cord-005453-4057qib7 15059 5 MM mm CD cord-005453-4057qib7 15059 6 patients patient NNS cord-005453-4057qib7 15059 7 , , , cord-005453-4057qib7 15059 8 aged age VBN cord-005453-4057qib7 15059 9 < < XX cord-005453-4057qib7 15059 10 66 66 CD cord-005453-4057qib7 15059 11 years year NNS cord-005453-4057qib7 15059 12 were be VBD cord-005453-4057qib7 15059 13 enrolled enrol VBN cord-005453-4057qib7 15059 14 if if IN cord-005453-4057qib7 15059 15 they -PRON- PRP cord-005453-4057qib7 15059 16 were be VBD cord-005453-4057qib7 15059 17 responsive responsive JJ cord-005453-4057qib7 15059 18 to to IN cord-005453-4057qib7 15059 19 their -PRON- PRP$ cord-005453-4057qib7 15059 20 last last JJ cord-005453-4057qib7 15059 21 line line NN cord-005453-4057qib7 15059 22 of of IN cord-005453-4057qib7 15059 23 therapy therapy NN cord-005453-4057qib7 15059 24 . . . cord-005453-4057qib7 15060 1 Poor poor JJ cord-005453-4057qib7 15060 2 risk risk NN cord-005453-4057qib7 15060 3 was be VBD cord-005453-4057qib7 15060 4 defined define VBN cord-005453-4057qib7 15060 5 as as IN cord-005453-4057qib7 15060 6 , , , cord-005453-4057qib7 15060 7 high high JJ cord-005453-4057qib7 15060 8 - - HYPH cord-005453-4057qib7 15060 9 risk risk NN cord-005453-4057qib7 15060 10 cytogenetics cytogenetic NNS cord-005453-4057qib7 15060 11 , , , cord-005453-4057qib7 15060 12 or or CC cord-005453-4057qib7 15060 13 relapse relapse VB cord-005453-4057qib7 15060 14 within within IN cord-005453-4057qib7 15060 15 a a DT cord-005453-4057qib7 15060 16 year year NN cord-005453-4057qib7 15060 17 after after IN cord-005453-4057qib7 15060 18 autologous autologous JJ cord-005453-4057qib7 15060 19 SCT SCT NNP cord-005453-4057qib7 15060 20 , , , cord-005453-4057qib7 15060 21 or or CC cord-005453-4057qib7 15060 22 treated treat VBN cord-005453-4057qib7 15060 23 with with IN cord-005453-4057qib7 15060 24 three three CD cord-005453-4057qib7 15060 25 or or CC cord-005453-4057qib7 15060 26 more more JJR cord-005453-4057qib7 15060 27 previous previous JJ cord-005453-4057qib7 15060 28 lines line NNS cord-005453-4057qib7 15060 29 of of IN cord-005453-4057qib7 15060 30 therapy therapy NN cord-005453-4057qib7 15060 31 . . . cord-005453-4057qib7 15061 1 A a DT cord-005453-4057qib7 15061 2 prerequisite prerequisite NN cord-005453-4057qib7 15061 3 of of IN cord-005453-4057qib7 15061 4 enrolment enrolment NN cord-005453-4057qib7 15061 5 was be VBD cord-005453-4057qib7 15061 6 the the DT cord-005453-4057qib7 15061 7 possibility possibility NN cord-005453-4057qib7 15061 8 of of IN cord-005453-4057qib7 15061 9 an an DT cord-005453-4057qib7 15061 10 NK NK NNP cord-005453-4057qib7 15061 11 cell cell NN cord-005453-4057qib7 15061 12 mismatch mismatch NN cord-005453-4057qib7 15061 13 and and CC cord-005453-4057qib7 15061 14 availability availability NN cord-005453-4057qib7 15061 15 of of IN cord-005453-4057qib7 15061 16 a a DT cord-005453-4057qib7 15061 17 mismatched mismatched JJ cord-005453-4057qib7 15061 18 family family NN cord-005453-4057qib7 15061 19 donor donor NN cord-005453-4057qib7 15061 20 . . . cord-005453-4057qib7 15062 1 Patients patient NNS cord-005453-4057qib7 15062 2 were be VBD cord-005453-4057qib7 15062 3 excluded exclude VBN cord-005453-4057qib7 15062 4 if if IN cord-005453-4057qib7 15062 5 donor donor NN cord-005453-4057qib7 15062 6 - - HYPH cord-005453-4057qib7 15062 7 specific specific JJ cord-005453-4057qib7 15062 8 HLA HLA NNP cord-005453-4057qib7 15062 9 - - HYPH cord-005453-4057qib7 15062 10 antibodies antibody NNS cord-005453-4057qib7 15062 11 were be VBD cord-005453-4057qib7 15062 12 present present JJ cord-005453-4057qib7 15062 13 . . . cord-005453-4057qib7 15063 1 Patients patient NNS cord-005453-4057qib7 15063 2 received receive VBD cord-005453-4057qib7 15063 3 a a DT cord-005453-4057qib7 15063 4 haploidentical haploidentical JJ cord-005453-4057qib7 15063 5 BMT BMT NNP cord-005453-4057qib7 15063 6 with with IN cord-005453-4057qib7 15063 7 a a DT cord-005453-4057qib7 15063 8 non non JJ cord-005453-4057qib7 15063 9 - - JJ cord-005453-4057qib7 15063 10 myeloablative myeloablative JJ cord-005453-4057qib7 15063 11 conditioning conditioning NN cord-005453-4057qib7 15063 12 regimen regimen NN cord-005453-4057qib7 15063 13 and and CC cord-005453-4057qib7 15063 14 post post JJ cord-005453-4057qib7 15063 15 - - JJ cord-005453-4057qib7 15063 16 transplant transplant NN cord-005453-4057qib7 15063 17 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 15063 18 . . . cord-005453-4057qib7 15064 1 Primary primary JJ cord-005453-4057qib7 15064 2 endpoint endpoint NN cord-005453-4057qib7 15064 3 is be VBZ cord-005453-4057qib7 15064 4 PFS PFS NNP cord-005453-4057qib7 15064 5 at at IN cord-005453-4057qib7 15064 6 1,5 1,5 CD cord-005453-4057qib7 15064 7 years year NNS cord-005453-4057qib7 15064 8 . . . cord-005453-4057qib7 15065 1 Secondary secondary JJ cord-005453-4057qib7 15065 2 endpoints endpoint NNS cord-005453-4057qib7 15065 3 are be VBP cord-005453-4057qib7 15065 4 engraftment engraftment NN cord-005453-4057qib7 15065 5 , , , cord-005453-4057qib7 15065 6 bone bone NN cord-005453-4057qib7 15065 7 marrow marrow NN cord-005453-4057qib7 15065 8 reconstitution reconstitution NN cord-005453-4057qib7 15065 9 , , , cord-005453-4057qib7 15065 10 NK NK NNP cord-005453-4057qib7 15065 11 cell cell NN cord-005453-4057qib7 15065 12 reconstitution reconstitution NN cord-005453-4057qib7 15065 13 and and CC cord-005453-4057qib7 15065 14 repertoire repertoire NN cord-005453-4057qib7 15065 15 , , , cord-005453-4057qib7 15065 16 graft graft NN cord-005453-4057qib7 15065 17 versus versus IN cord-005453-4057qib7 15065 18 host host NN cord-005453-4057qib7 15065 19 disease disease NN cord-005453-4057qib7 15065 20 ( ( -LRB- cord-005453-4057qib7 15065 21 GVHD GVHD NNP cord-005453-4057qib7 15065 22 ) ) -RRB- cord-005453-4057qib7 15065 23 , , , cord-005453-4057qib7 15065 24 infections infection NNS cord-005453-4057qib7 15065 25 and and CC cord-005453-4057qib7 15065 26 non non JJ cord-005453-4057qib7 15065 27 - - JJ cord-005453-4057qib7 15065 28 relapse relapse JJ cord-005453-4057qib7 15065 29 mortality mortality NN cord-005453-4057qib7 15065 30 ( ( -LRB- cord-005453-4057qib7 15065 31 NRM NRM NNP cord-005453-4057qib7 15065 32 ) ) -RRB- cord-005453-4057qib7 15065 33 at at IN cord-005453-4057qib7 15065 34 1,5 1,5 CD cord-005453-4057qib7 15065 35 years year NNS cord-005453-4057qib7 15065 36 . . . cord-005453-4057qib7 15066 1 Results result NNS cord-005453-4057qib7 15066 2 : : : cord-005453-4057qib7 15067 1 In in IN cord-005453-4057qib7 15067 2 total total JJ cord-005453-4057qib7 15067 3 12 12 CD cord-005453-4057qib7 15067 4 poor poor JJ cord-005453-4057qib7 15067 5 risk risk NN cord-005453-4057qib7 15067 6 patients patient NNS cord-005453-4057qib7 15067 7 were be VBD cord-005453-4057qib7 15067 8 included include VBN cord-005453-4057qib7 15067 9 in in IN cord-005453-4057qib7 15067 10 the the DT cord-005453-4057qib7 15067 11 study study NN cord-005453-4057qib7 15067 12 of of IN cord-005453-4057qib7 15067 13 which which WDT cord-005453-4057qib7 15067 14 10 10 CD cord-005453-4057qib7 15067 15 could could MD cord-005453-4057qib7 15067 16 be be VB cord-005453-4057qib7 15067 17 evaluated evaluate VBN cord-005453-4057qib7 15067 18 for for IN cord-005453-4057qib7 15067 19 the the DT cord-005453-4057qib7 15067 20 primary primary JJ cord-005453-4057qib7 15067 21 end end NN cord-005453-4057qib7 15067 22 point point NN cord-005453-4057qib7 15067 23 . . . cord-005453-4057qib7 15068 1 Graft graft NN cord-005453-4057qib7 15068 2 failure failure NN cord-005453-4057qib7 15068 3 and and CC cord-005453-4057qib7 15068 4 disease disease NN cord-005453-4057qib7 15068 5 progression progression NN cord-005453-4057qib7 15068 6 before before IN cord-005453-4057qib7 15068 7 transplant transplant NN cord-005453-4057qib7 15068 8 rendered render VBD cord-005453-4057qib7 15068 9 the the DT cord-005453-4057qib7 15068 10 remaining remain VBG cord-005453-4057qib7 15068 11 two two CD cord-005453-4057qib7 15068 12 patients patient NNS cord-005453-4057qib7 15068 13 not not RB cord-005453-4057qib7 15068 14 evaluable evaluable JJ cord-005453-4057qib7 15068 15 . . . cord-005453-4057qib7 15069 1 At at IN cord-005453-4057qib7 15069 2 this this DT cord-005453-4057qib7 15069 3 interim interim JJ cord-005453-4057qib7 15069 4 analysis analysis NN cord-005453-4057qib7 15069 5 7 7 CD cord-005453-4057qib7 15069 6 patients patient NNS cord-005453-4057qib7 15069 7 have have VBP cord-005453-4057qib7 15069 8 already already RB cord-005453-4057qib7 15069 9 reached reach VBN cord-005453-4057qib7 15069 10 the the DT cord-005453-4057qib7 15069 11 1,5 1,5 CD cord-005453-4057qib7 15069 12 years year NNS cord-005453-4057qib7 15069 13 of of IN cord-005453-4057qib7 15069 14 follow follow VBP cord-005453-4057qib7 15069 15 up up RB cord-005453-4057qib7 15069 16 , , , cord-005453-4057qib7 15069 17 5 5 CD cord-005453-4057qib7 15069 18 relapsed relapse VBD cord-005453-4057qib7 15069 19 within within IN cord-005453-4057qib7 15069 20 1,5 1,5 CD cord-005453-4057qib7 15069 21 years year NNS cord-005453-4057qib7 15069 22 and and CC cord-005453-4057qib7 15069 23 2 2 CD cord-005453-4057qib7 15069 24 died die VBD cord-005453-4057qib7 15069 25 due due JJ cord-005453-4057qib7 15069 26 to to IN cord-005453-4057qib7 15069 27 treatment treatment NN cord-005453-4057qib7 15069 28 related relate VBN cord-005453-4057qib7 15069 29 infections infection NNS cord-005453-4057qib7 15069 30 , , , cord-005453-4057qib7 15069 31 without without IN cord-005453-4057qib7 15069 32 showing show VBG cord-005453-4057qib7 15069 33 progression progression NN cord-005453-4057qib7 15069 34 of of IN cord-005453-4057qib7 15069 35 disease disease NN cord-005453-4057qib7 15069 36 ( ( -LRB- cord-005453-4057qib7 15069 37 20 20 CD cord-005453-4057qib7 15069 38 % % NN cord-005453-4057qib7 15069 39 NRM NRM NNP cord-005453-4057qib7 15069 40 ) ) -RRB- cord-005453-4057qib7 15069 41 . . . cord-005453-4057qib7 15070 1 Average average JJ cord-005453-4057qib7 15070 2 time time NN cord-005453-4057qib7 15070 3 of of IN cord-005453-4057qib7 15070 4 progression progression NN cord-005453-4057qib7 15070 5 is be VBZ cord-005453-4057qib7 15070 6 105 105 CD cord-005453-4057qib7 15070 7 days day NNS cord-005453-4057qib7 15070 8 ( ( -LRB- cord-005453-4057qib7 15070 9 60 60 CD cord-005453-4057qib7 15070 10 - - SYM cord-005453-4057qib7 15070 11 270 270 CD cord-005453-4057qib7 15070 12 days day NNS cord-005453-4057qib7 15070 13 ) ) -RRB- cord-005453-4057qib7 15070 14 . . . cord-005453-4057qib7 15071 1 Two two CD cord-005453-4057qib7 15071 2 of of IN cord-005453-4057qib7 15071 3 the the DT cord-005453-4057qib7 15071 4 remaining remain VBG cord-005453-4057qib7 15071 5 patients patient NNS cord-005453-4057qib7 15071 6 at at IN cord-005453-4057qib7 15071 7 follow follow VB cord-005453-4057qib7 15071 8 up up RP cord-005453-4057qib7 15071 9 , , , cord-005453-4057qib7 15071 10 still still RB cord-005453-4057qib7 15071 11 show show VB cord-005453-4057qib7 15071 12 responsive responsive JJ cord-005453-4057qib7 15071 13 disease disease NN cord-005453-4057qib7 15071 14 ( ( -LRB- cord-005453-4057qib7 15071 15 days day NNS cord-005453-4057qib7 15071 16 210 210 CD cord-005453-4057qib7 15071 17 en en NN cord-005453-4057qib7 15071 18 120 120 CD cord-005453-4057qib7 15071 19 ) ) -RRB- cord-005453-4057qib7 15071 20 . . . cord-005453-4057qib7 15072 1 The the DT cord-005453-4057qib7 15072 2 average average JJ cord-005453-4057qib7 15072 3 time time NN cord-005453-4057qib7 15072 4 to to IN cord-005453-4057qib7 15072 5 neutrophil neutrophil NN cord-005453-4057qib7 15072 6 reconstitution reconstitution NN cord-005453-4057qib7 15072 7 is be VBZ cord-005453-4057qib7 15072 8 19 19 CD cord-005453-4057qib7 15072 9 days day NNS cord-005453-4057qib7 15072 10 ( ( -LRB- cord-005453-4057qib7 15072 11 14 14 CD cord-005453-4057qib7 15072 12 - - SYM cord-005453-4057qib7 15072 13 28 28 CD cord-005453-4057qib7 15072 14 days day NNS cord-005453-4057qib7 15072 15 ) ) -RRB- cord-005453-4057qib7 15072 16 . . . cord-005453-4057qib7 15073 1 All all DT cord-005453-4057qib7 15073 2 evaluated evaluate VBN cord-005453-4057qib7 15073 3 patients patient NNS cord-005453-4057qib7 15073 4 ( ( -LRB- cord-005453-4057qib7 15073 5 6/10 6/10 CD cord-005453-4057qib7 15073 6 ) ) -RRB- cord-005453-4057qib7 15073 7 show show VBP cord-005453-4057qib7 15073 8 NK NK NNP cord-005453-4057qib7 15073 9 cell cell NN cord-005453-4057qib7 15073 10 reconstitution reconstitution NN cord-005453-4057qib7 15073 11 with with IN cord-005453-4057qib7 15073 12 a a DT cord-005453-4057qib7 15073 13 mature mature JJ cord-005453-4057qib7 15073 14 phenotype phenotype NN cord-005453-4057qib7 15073 15 in in IN cord-005453-4057qib7 15073 16 the the DT cord-005453-4057qib7 15073 17 bone bone NN cord-005453-4057qib7 15073 18 marrow marrow NN cord-005453-4057qib7 15073 19 and and CC cord-005453-4057qib7 15073 20 peripheral peripheral JJ cord-005453-4057qib7 15073 21 blood blood NN cord-005453-4057qib7 15073 22 by by IN cord-005453-4057qib7 15073 23 day day NN cord-005453-4057qib7 15073 24 60 60 CD cord-005453-4057qib7 15073 25 . . . cord-005453-4057qib7 15074 1 Three three CD cord-005453-4057qib7 15074 2 patients patient NNS cord-005453-4057qib7 15074 3 developed develop VBD cord-005453-4057qib7 15074 4 acute acute JJ cord-005453-4057qib7 15074 5 GVHD GVHD NNP cord-005453-4057qib7 15074 6 ( ( -LRB- cord-005453-4057qib7 15074 7 25 25 CD cord-005453-4057qib7 15074 8 % % NN cord-005453-4057qib7 15074 9 ) ) -RRB- cord-005453-4057qib7 15074 10 of of IN cord-005453-4057qib7 15074 11 which which WDT cord-005453-4057qib7 15074 12 2/12 2/12 CD cord-005453-4057qib7 15074 13 grade grade NN cord-005453-4057qib7 15074 14 I I NNP cord-005453-4057qib7 15074 15 - - HYPH cord-005453-4057qib7 15074 16 II II NNP cord-005453-4057qib7 15074 17 aGVHD agvhd NN cord-005453-4057qib7 15074 18 and and CC cord-005453-4057qib7 15074 19 1/12 1/12 CD cord-005453-4057qib7 15074 20 patient patient NN cord-005453-4057qib7 15074 21 showed show VBD cord-005453-4057qib7 15074 22 a a DT cord-005453-4057qib7 15074 23 grade grade NN cord-005453-4057qib7 15074 24 IV IV NNP cord-005453-4057qib7 15074 25 aGVHD aGVHD NNP cord-005453-4057qib7 15074 26 . . . cord-005453-4057qib7 15075 1 Treatment treatment NN cord-005453-4057qib7 15075 2 related related JJ cord-005453-4057qib7 15075 3 mortality mortality NN cord-005453-4057qib7 15075 4 was be VBD cord-005453-4057qib7 15075 5 3/12 3/12 CD cord-005453-4057qib7 15075 6 ( ( -LRB- cord-005453-4057qib7 15075 7 25 25 CD cord-005453-4057qib7 15075 8 % % NN cord-005453-4057qib7 15075 9 ) ) -RRB- cord-005453-4057qib7 15075 10 , , , cord-005453-4057qib7 15075 11 which which WDT cord-005453-4057qib7 15075 12 was be VBD cord-005453-4057qib7 15075 13 in in IN cord-005453-4057qib7 15075 14 all all DT cord-005453-4057qib7 15075 15 cases case NNS cord-005453-4057qib7 15075 16 due due JJ cord-005453-4057qib7 15075 17 to to IN cord-005453-4057qib7 15075 18 infectious infectious JJ cord-005453-4057qib7 15075 19 disease disease NN cord-005453-4057qib7 15075 20 . . . cord-005453-4057qib7 15076 1 Conclusions conclusion NNS cord-005453-4057qib7 15076 2 : : : cord-005453-4057qib7 15077 1 Our -PRON- PRP$ cord-005453-4057qib7 15077 2 interim interim JJ cord-005453-4057qib7 15077 3 analysis analysis NN cord-005453-4057qib7 15077 4 of of IN cord-005453-4057qib7 15077 5 mismatched mismatched JJ cord-005453-4057qib7 15077 6 haploidentical haploidentical JJ cord-005453-4057qib7 15077 7 BMT BMT NNP cord-005453-4057qib7 15077 8 in in IN cord-005453-4057qib7 15077 9 MM MM NNP cord-005453-4057qib7 15077 10 showed show VBD cord-005453-4057qib7 15077 11 that that IN cord-005453-4057qib7 15077 12 the the DT cord-005453-4057qib7 15077 13 treatment treatment NN cord-005453-4057qib7 15077 14 is be VBZ cord-005453-4057qib7 15077 15 feasible feasible JJ cord-005453-4057qib7 15077 16 and and CC cord-005453-4057qib7 15077 17 forms form VBZ cord-005453-4057qib7 15077 18 a a DT cord-005453-4057qib7 15077 19 possible possible JJ cord-005453-4057qib7 15077 20 platform platform NN cord-005453-4057qib7 15077 21 for for IN cord-005453-4057qib7 15077 22 immunotherapeutic immunotherapeutic JJ cord-005453-4057qib7 15077 23 strategies strategy NNS cord-005453-4057qib7 15077 24 . . . cord-005453-4057qib7 15078 1 The the DT cord-005453-4057qib7 15078 2 majority majority NN cord-005453-4057qib7 15078 3 of of IN cord-005453-4057qib7 15078 4 patients patient NNS cord-005453-4057qib7 15078 5 showed show VBD cord-005453-4057qib7 15078 6 an an DT cord-005453-4057qib7 15078 7 early early JJ cord-005453-4057qib7 15078 8 disease disease NN cord-005453-4057qib7 15078 9 progression progression NN cord-005453-4057qib7 15078 10 . . . cord-005453-4057qib7 15079 1 We -PRON- PRP cord-005453-4057qib7 15079 2 predefined predefine VBD cord-005453-4057qib7 15079 3 that that DT cord-005453-4057qib7 15079 4 with with IN cord-005453-4057qib7 15079 5 a a DT cord-005453-4057qib7 15079 6 PFS PFS NNP cord-005453-4057qib7 15079 7 of of IN cord-005453-4057qib7 15079 8 25 25 CD cord-005453-4057qib7 15079 9 % % NN cord-005453-4057qib7 15079 10 at at IN cord-005453-4057qib7 15079 11 1,5 1,5 CD cord-005453-4057qib7 15079 12 years year NNS cord-005453-4057qib7 15079 13 we -PRON- PRP cord-005453-4057qib7 15079 14 would would MD cord-005453-4057qib7 15079 15 qualify qualify VB cord-005453-4057qib7 15079 16 this this DT cord-005453-4057qib7 15079 17 treatment treatment NN cord-005453-4057qib7 15079 18 option option NN cord-005453-4057qib7 15079 19 successful successful JJ cord-005453-4057qib7 15079 20 . . . cord-005453-4057qib7 15080 1 With with IN cord-005453-4057qib7 15080 2 only only RB cord-005453-4057qib7 15080 3 two two CD cord-005453-4057qib7 15080 4 patients patient NNS cord-005453-4057qib7 15080 5 still still RB cord-005453-4057qib7 15080 6 in in IN cord-005453-4057qib7 15080 7 remission remission NN cord-005453-4057qib7 15080 8 this this DT cord-005453-4057qib7 15080 9 goal goal NN cord-005453-4057qib7 15080 10 will will MD cord-005453-4057qib7 15080 11 not not RB cord-005453-4057qib7 15080 12 be be VB cord-005453-4057qib7 15080 13 achieved achieve VBN cord-005453-4057qib7 15080 14 and and CC cord-005453-4057qib7 15080 15 we -PRON- PRP cord-005453-4057qib7 15080 16 hypothesize hypothesize VBP cord-005453-4057qib7 15080 17 that that IN cord-005453-4057qib7 15080 18 the the DT cord-005453-4057qib7 15080 19 late late JJ cord-005453-4057qib7 15080 20 NK NK NNP cord-005453-4057qib7 15080 21 cell cell NN cord-005453-4057qib7 15080 22 reconstitution reconstitution NN cord-005453-4057qib7 15080 23 ( ( -LRB- cord-005453-4057qib7 15080 24 day day NN cord-005453-4057qib7 15080 25 60 60 CD cord-005453-4057qib7 15080 26 ) ) -RRB- cord-005453-4057qib7 15080 27 is be VBZ cord-005453-4057qib7 15080 28 responsible responsible JJ cord-005453-4057qib7 15080 29 for for IN cord-005453-4057qib7 15080 30 the the DT cord-005453-4057qib7 15080 31 lack lack NN cord-005453-4057qib7 15080 32 of of IN cord-005453-4057qib7 15080 33 response response NN cord-005453-4057qib7 15080 34 . . . cord-005453-4057qib7 15081 1 Clinical clinical JJ cord-005453-4057qib7 15081 2 Background background NN cord-005453-4057qib7 15081 3 : : : cord-005453-4057qib7 15081 4 MSCs msc NNS cord-005453-4057qib7 15081 5 are be VBP cord-005453-4057qib7 15081 6 known know VBN cord-005453-4057qib7 15081 7 to to TO cord-005453-4057qib7 15081 8 have have VB cord-005453-4057qib7 15081 9 immune immune JJ cord-005453-4057qib7 15081 10 modulatory modulatory JJ cord-005453-4057qib7 15081 11 capacity capacity NN cord-005453-4057qib7 15081 12 and and CC cord-005453-4057qib7 15081 13 may may MD cord-005453-4057qib7 15081 14 be be VB cord-005453-4057qib7 15081 15 effective effective JJ cord-005453-4057qib7 15081 16 in in IN cord-005453-4057qib7 15081 17 the the DT cord-005453-4057qib7 15081 18 treatment treatment NN cord-005453-4057qib7 15081 19 of of IN cord-005453-4057qib7 15081 20 patients patient NNS cord-005453-4057qib7 15081 21 with with IN cord-005453-4057qib7 15081 22 acute acute JJ cord-005453-4057qib7 15081 23 GVHD GVHD NNP cord-005453-4057qib7 15081 24 . . . cord-005453-4057qib7 15082 1 However however WRB cord-005453-4057qib7 15082 2 clinical clinical JJ cord-005453-4057qib7 15082 3 studies study NNS cord-005453-4057qib7 15082 4 yielded yield VBD cord-005453-4057qib7 15082 5 inconclusive inconclusive JJ cord-005453-4057qib7 15082 6 results result NNS cord-005453-4057qib7 15082 7 which which WDT cord-005453-4057qib7 15082 8 was be VBD cord-005453-4057qib7 15082 9 in in IN cord-005453-4057qib7 15082 10 part part NN cord-005453-4057qib7 15082 11 due due IN cord-005453-4057qib7 15082 12 to to IN cord-005453-4057qib7 15082 13 the the DT cord-005453-4057qib7 15082 14 great great JJ cord-005453-4057qib7 15082 15 heterogeneity heterogeneity NN cord-005453-4057qib7 15082 16 of of IN cord-005453-4057qib7 15082 17 the the DT cord-005453-4057qib7 15082 18 MSC MSC NNP cord-005453-4057qib7 15082 19 used use VBD cord-005453-4057qib7 15082 20 . . . cord-005453-4057qib7 15083 1 The the DT cord-005453-4057qib7 15083 2 off off IN cord-005453-4057qib7 15083 3 - - HYPH cord-005453-4057qib7 15083 4 the the DT cord-005453-4057qib7 15083 5 - - HYPH cord-005453-4057qib7 15083 6 shelf shelf NN cord-005453-4057qib7 15083 7 MSC MSC NNP cord-005453-4057qib7 15083 8 preparation preparation NN cord-005453-4057qib7 15083 9 " " `` cord-005453-4057qib7 15083 10 MSC MSC NNP cord-005453-4057qib7 15083 11 - - HYPH cord-005453-4057qib7 15083 12 FFM FFM NNP cord-005453-4057qib7 15083 13 " " '' cord-005453-4057qib7 15083 14 , , , cord-005453-4057qib7 15083 15 generated generate VBN cord-005453-4057qib7 15083 16 by by IN cord-005453-4057qib7 15083 17 a a DT cord-005453-4057qib7 15083 18 proprietary proprietary JJ cord-005453-4057qib7 15083 19 pooling pooling NN cord-005453-4057qib7 15083 20 process process NN cord-005453-4057qib7 15083 21 , , , cord-005453-4057qib7 15083 22 selection selection NN cord-005453-4057qib7 15083 23 by by IN cord-005453-4057qib7 15083 24 plastic plastic NN cord-005453-4057qib7 15083 25 - - HYPH cord-005453-4057qib7 15083 26 adherence adherence NN cord-005453-4057qib7 15083 27 , , , cord-005453-4057qib7 15083 28 expansion expansion NN cord-005453-4057qib7 15083 29 for for IN cord-005453-4057qib7 15083 30 an an DT cord-005453-4057qib7 15083 31 aggregate aggregate JJ cord-005453-4057qib7 15083 32 four four CD cord-005453-4057qib7 15083 33 weeks week NNS cord-005453-4057qib7 15083 34 followed follow VBN cord-005453-4057qib7 15083 35 by by IN cord-005453-4057qib7 15083 36 cryopreservation cryopreservation NN cord-005453-4057qib7 15083 37 until until IN cord-005453-4057qib7 15083 38 use use NN cord-005453-4057qib7 15083 39 , , , cord-005453-4057qib7 15083 40 is be VBZ cord-005453-4057qib7 15083 41 available available JJ cord-005453-4057qib7 15083 42 in in IN cord-005453-4057qib7 15083 43 Germany Germany NNP cord-005453-4057qib7 15083 44 through through IN cord-005453-4057qib7 15083 45 a a DT cord-005453-4057qib7 15083 46 national national JJ cord-005453-4057qib7 15083 47 marketing marketing NN cord-005453-4057qib7 15083 48 authorization authorization NN cord-005453-4057qib7 15083 49 . . . cord-005453-4057qib7 15084 1 " " '' cord-005453-4057qib7 15085 1 MSC MSC NNP cord-005453-4057qib7 15085 2 - - HYPH cord-005453-4057qib7 15085 3 FFM FFM NNP cord-005453-4057qib7 15085 4 " " '' cord-005453-4057qib7 15085 5 is be VBZ cord-005453-4057qib7 15085 6 indicated indicate VBN cord-005453-4057qib7 15085 7 in in IN cord-005453-4057qib7 15085 8 steroidrefractory steroidrefractory NNP cord-005453-4057qib7 15085 9 aGvHD aGvHD NNP cord-005453-4057qib7 15085 10 , , , cord-005453-4057qib7 15085 11 dosed dose VBN cord-005453-4057qib7 15085 12 at at IN cord-005453-4057qib7 15085 13 1 1 CD cord-005453-4057qib7 15085 14 - - SYM cord-005453-4057qib7 15085 15 2 2 CD cord-005453-4057qib7 15085 16 x10 x10 CD cord-005453-4057qib7 15085 17 6 6 CD cord-005453-4057qib7 15085 18 /kg /kg NN cord-005453-4057qib7 15085 19 BW BW NNP cord-005453-4057qib7 15085 20 i.v i.v NNP cord-005453-4057qib7 15085 21 . . . cord-005453-4057qib7 15086 1 in in IN cord-005453-4057qib7 15086 2 four four CD cord-005453-4057qib7 15086 3 doses dose NNS cord-005453-4057qib7 15086 4 one one CD cord-005453-4057qib7 15086 5 week week NN cord-005453-4057qib7 15086 6 apart apart RB cord-005453-4057qib7 15086 7 . . . cord-005453-4057qib7 15087 1 Methods method NNS cord-005453-4057qib7 15087 2 : : : cord-005453-4057qib7 15087 3 We -PRON- PRP cord-005453-4057qib7 15087 4 report report VBP cord-005453-4057qib7 15087 5 seven seven CD cord-005453-4057qib7 15087 6 consecutive consecutive JJ cord-005453-4057qib7 15087 7 pediatric pediatric JJ cord-005453-4057qib7 15087 8 patients patient NNS cord-005453-4057qib7 15087 9 ( ( -LRB- cord-005453-4057qib7 15087 10 median median JJ cord-005453-4057qib7 15087 11 age age NN cord-005453-4057qib7 15087 12 7.49 7.49 CD cord-005453-4057qib7 15087 13 y y NNP cord-005453-4057qib7 15087 14 ) ) -RRB- cord-005453-4057qib7 15087 15 , , , cord-005453-4057qib7 15087 16 who who WP cord-005453-4057qib7 15087 17 received receive VBD cord-005453-4057qib7 15087 18 " " `` cord-005453-4057qib7 15087 19 MSC MSC NNP cord-005453-4057qib7 15087 20 - - HYPH cord-005453-4057qib7 15087 21 FFM FFM NNP cord-005453-4057qib7 15087 22 " " '' cord-005453-4057qib7 15087 23 from from IN cord-005453-4057qib7 15087 24 unrelated unrelated JJ cord-005453-4057qib7 15087 25 HLA HLA NNP cord-005453-4057qib7 15087 26 disparate disparate JJ cord-005453-4057qib7 15087 27 donors donor NNS cord-005453-4057qib7 15087 28 between between IN cord-005453-4057qib7 15087 29 December December NNP cord-005453-4057qib7 15087 30 2017 2017 CD cord-005453-4057qib7 15087 31 and and CC cord-005453-4057qib7 15087 32 November November NNP cord-005453-4057qib7 15087 33 2018 2018 CD cord-005453-4057qib7 15087 34 in in IN cord-005453-4057qib7 15087 35 our -PRON- PRP$ cord-005453-4057qib7 15087 36 institution institution NN cord-005453-4057qib7 15087 37 . . . cord-005453-4057qib7 15088 1 We -PRON- PRP cord-005453-4057qib7 15088 2 gave give VBD cord-005453-4057qib7 15088 3 MSC MSC NNP cord-005453-4057qib7 15088 4 infusions infusion NNS cord-005453-4057qib7 15088 5 to to IN cord-005453-4057qib7 15088 6 6 6 CD cord-005453-4057qib7 15088 7 patients patient NNS cord-005453-4057qib7 15088 8 with with IN cord-005453-4057qib7 15088 9 steroid steroid JJ cord-005453-4057qib7 15088 10 - - HYPH cord-005453-4057qib7 15088 11 refractory refractory JJ cord-005453-4057qib7 15088 12 grades grade NNS cord-005453-4057qib7 15088 13 III III NNP cord-005453-4057qib7 15088 14 - - HYPH cord-005453-4057qib7 15088 15 IV IV NNP cord-005453-4057qib7 15088 16 aGVHD aGVHD NNP cord-005453-4057qib7 15088 17 and and CC cord-005453-4057qib7 15088 18 one one CD cord-005453-4057qib7 15088 19 patient patient NN cord-005453-4057qib7 15088 20 who who WP cord-005453-4057qib7 15088 21 had have VBD cord-005453-4057qib7 15088 22 therapy therapy NN cord-005453-4057qib7 15088 23 - - HYPH cord-005453-4057qib7 15088 24 refractory refractory JJ cord-005453-4057qib7 15088 25 Background background NN cord-005453-4057qib7 15088 26 : : : cord-005453-4057qib7 15088 27 Regulatory regulatory JJ cord-005453-4057qib7 15088 28 T t NN cord-005453-4057qib7 15088 29 cells cell NNS cord-005453-4057qib7 15088 30 ( ( -LRB- cord-005453-4057qib7 15088 31 Treg Treg NNP cord-005453-4057qib7 15088 32 ) ) -RRB- cord-005453-4057qib7 15088 33 are be VBP cord-005453-4057qib7 15088 34 known know VBN cord-005453-4057qib7 15088 35 for for IN cord-005453-4057qib7 15088 36 their -PRON- PRP$ cord-005453-4057qib7 15088 37 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 15088 38 function function NN cord-005453-4057qib7 15088 39 and and CC cord-005453-4057qib7 15088 40 have have VBP cord-005453-4057qib7 15088 41 proven prove VBN cord-005453-4057qib7 15088 42 successful successful JJ cord-005453-4057qib7 15088 43 as as IN cord-005453-4057qib7 15088 44 graft graft NN cord-005453-4057qib7 15088 45 - - HYPH cord-005453-4057qib7 15088 46 versus versus IN cord-005453-4057qib7 15088 47 - - HYPH cord-005453-4057qib7 15088 48 host host NN cord-005453-4057qib7 15088 49 disease disease NN cord-005453-4057qib7 15088 50 ( ( -LRB- cord-005453-4057qib7 15088 51 GVHD GVHD NNP cord-005453-4057qib7 15088 52 ) ) -RRB- cord-005453-4057qib7 15088 53 prophylaxis prophylaxis NN cord-005453-4057qib7 15088 54 after after IN cord-005453-4057qib7 15088 55 allogeneic allogeneic NN cord-005453-4057qib7 15088 56 bone bone NN cord-005453-4057qib7 15088 57 marrow marrow NN cord-005453-4057qib7 15088 58 transplantation transplantation NN cord-005453-4057qib7 15088 59 in in IN cord-005453-4057qib7 15088 60 a a DT cord-005453-4057qib7 15088 61 number number NN cord-005453-4057qib7 15088 62 of of IN cord-005453-4057qib7 15088 63 preclinical preclinical JJ cord-005453-4057qib7 15088 64 as as RB cord-005453-4057qib7 15088 65 well well RB cord-005453-4057qib7 15088 66 as as IN cord-005453-4057qib7 15088 67 first first JJ cord-005453-4057qib7 15088 68 clinical clinical JJ cord-005453-4057qib7 15088 69 studies study NNS cord-005453-4057qib7 15088 70 without without IN cord-005453-4057qib7 15088 71 compromising compromise VBG cord-005453-4057qib7 15088 72 graft graft NN cord-005453-4057qib7 15088 73 - - HYPH cord-005453-4057qib7 15088 74 versus versus RP cord-005453-4057qib7 15088 75 leukemia leukemia NN cord-005453-4057qib7 15088 76 ( ( -LRB- cord-005453-4057qib7 15088 77 GVL gvl NN cord-005453-4057qib7 15088 78 ) ) -RRB- cord-005453-4057qib7 15088 79 effects effect NNS cord-005453-4057qib7 15088 80 . . . cord-005453-4057qib7 15089 1 In in IN cord-005453-4057qib7 15089 2 murine murine JJ cord-005453-4057qib7 15089 3 models model NNS cord-005453-4057qib7 15089 4 of of IN cord-005453-4057qib7 15089 5 acute acute JJ cord-005453-4057qib7 15089 6 GVHD GVHD NNP cord-005453-4057qib7 15089 7 lymph lymph NN cord-005453-4057qib7 15089 8 node node NN cord-005453-4057qib7 15089 9 homing home VBG cord-005453-4057qib7 15089 10 capacity capacity NN cord-005453-4057qib7 15089 11 via via IN cord-005453-4057qib7 15089 12 CD62L cd62l NN cord-005453-4057qib7 15090 1 ( ( -LRB- cord-005453-4057qib7 15090 2 L l NN cord-005453-4057qib7 15090 3 - - HYPH cord-005453-4057qib7 15090 4 selectin selectin NNP cord-005453-4057qib7 15090 5 ) ) -RRB- cord-005453-4057qib7 15090 6 proved prove VBD cord-005453-4057qib7 15090 7 to to TO cord-005453-4057qib7 15090 8 be be VB cord-005453-4057qib7 15090 9 essential essential JJ cord-005453-4057qib7 15090 10 for for IN cord-005453-4057qib7 15090 11 disease disease NN cord-005453-4057qib7 15090 12 prevention prevention NN cord-005453-4057qib7 15090 13 . . . cord-005453-4057qib7 15091 1 Yet yet RB cord-005453-4057qib7 15091 2 , , , cord-005453-4057qib7 15091 3 Treg Treg NNP cord-005453-4057qib7 15091 4 recruitment recruitment NN cord-005453-4057qib7 15091 5 from from IN cord-005453-4057qib7 15091 6 lymph lymph NN cord-005453-4057qib7 15091 7 nodes node NNS cord-005453-4057qib7 15091 8 to to IN cord-005453-4057qib7 15091 9 peripheral peripheral JJ cord-005453-4057qib7 15091 10 sites site NNS cord-005453-4057qib7 15091 11 of of IN cord-005453-4057qib7 15091 12 ongoing ongoing JJ cord-005453-4057qib7 15091 13 GVHD GVHD NNP cord-005453-4057qib7 15091 14 also also RB cord-005453-4057qib7 15091 15 seems seem VBZ cord-005453-4057qib7 15091 16 necessary necessary JJ cord-005453-4057qib7 15091 17 to to TO cord-005453-4057qib7 15091 18 achieve achieve VB cord-005453-4057qib7 15091 19 maximum maximum JJ cord-005453-4057qib7 15091 20 protective protective NN cord-005453-4057qib7 15091 21 as as RB cord-005453-4057qib7 15091 22 well well RB cord-005453-4057qib7 15091 23 as as IN cord-005453-4057qib7 15091 24 therapeutic therapeutic JJ cord-005453-4057qib7 15091 25 effects effect NNS cord-005453-4057qib7 15091 26 . . . cord-005453-4057qib7 15092 1 The the DT cord-005453-4057qib7 15092 2 chemokine chemokine NN cord-005453-4057qib7 15092 3 receptor receptor NN cord-005453-4057qib7 15092 4 CCR4 CCR4 NNP cord-005453-4057qib7 15092 5 directs direct VBZ cord-005453-4057qib7 15092 6 activated activate VBN cord-005453-4057qib7 15092 7 T t NN cord-005453-4057qib7 15092 8 cells cell NNS cord-005453-4057qib7 15092 9 to to IN cord-005453-4057qib7 15092 10 sites site NNS cord-005453-4057qib7 15092 11 of of IN cord-005453-4057qib7 15092 12 inflammation inflammation NN cord-005453-4057qib7 15092 13 , , , cord-005453-4057qib7 15092 14 thus thus RB cord-005453-4057qib7 15092 15 high high JJ cord-005453-4057qib7 15092 16 CCR4 CCR4 NNP cord-005453-4057qib7 15092 17 expression expression NN cord-005453-4057qib7 15092 18 should should MD cord-005453-4057qib7 15092 19 facilitate facilitate VB cord-005453-4057qib7 15092 20 Treg Treg NNP cord-005453-4057qib7 15092 21 homing homing NN cord-005453-4057qib7 15092 22 to to IN cord-005453-4057qib7 15092 23 affected affect VBN cord-005453-4057qib7 15092 24 GVHD GVHD NNP cord-005453-4057qib7 15092 25 target target NN cord-005453-4057qib7 15092 26 organs organ NNS cord-005453-4057qib7 15092 27 . . . cord-005453-4057qib7 15093 1 With with IN cord-005453-4057qib7 15093 2 this this DT cord-005453-4057qib7 15093 3 project project NN cord-005453-4057qib7 15093 4 we -PRON- PRP cord-005453-4057qib7 15093 5 lay lay VBP cord-005453-4057qib7 15093 6 the the DT cord-005453-4057qib7 15093 7 foundation foundation NN cord-005453-4057qib7 15093 8 for for IN cord-005453-4057qib7 15093 9 future future NN cord-005453-4057qib7 15093 10 in in IN cord-005453-4057qib7 15093 11 vivo vivo NN cord-005453-4057qib7 15093 12 studies study NNS cord-005453-4057qib7 15093 13 of of IN cord-005453-4057qib7 15093 14 Treg Treg NNP cord-005453-4057qib7 15093 15 therapy therapy NN cord-005453-4057qib7 15093 16 for for IN cord-005453-4057qib7 15093 17 GVHD GVHD NNP cord-005453-4057qib7 15093 18 by by IN cord-005453-4057qib7 15093 19 upregulation upregulation NN cord-005453-4057qib7 15093 20 of of IN cord-005453-4057qib7 15093 21 CCR4 CCR4 NNP cord-005453-4057qib7 15093 22 expression expression NN cord-005453-4057qib7 15093 23 . . . cord-005453-4057qib7 15094 1 Methods method NNS cord-005453-4057qib7 15094 2 : : : cord-005453-4057qib7 15094 3 We -PRON- PRP cord-005453-4057qib7 15094 4 performed perform VBD cord-005453-4057qib7 15094 5 systematic systematic JJ cord-005453-4057qib7 15094 6 ex ex FW cord-005453-4057qib7 15094 7 vivo vivo NN cord-005453-4057qib7 15094 8 analysis analysis NN cord-005453-4057qib7 15094 9 of of IN cord-005453-4057qib7 15094 10 CCR4 CCR4 NNP cord-005453-4057qib7 15094 11 expression expression NN cord-005453-4057qib7 15094 12 on on IN cord-005453-4057qib7 15094 13 murine murine JJ cord-005453-4057qib7 15094 14 naive naive JJ cord-005453-4057qib7 15094 15 and and CC cord-005453-4057qib7 15094 16 memory memory NN cord-005453-4057qib7 15094 17 conventional conventional JJ cord-005453-4057qib7 15094 18 ( ( -LRB- cord-005453-4057qib7 15094 19 Tconv Tconv NNP cord-005453-4057qib7 15094 20 ) ) -RRB- cord-005453-4057qib7 15094 21 and and CC cord-005453-4057qib7 15094 22 regulatory regulatory JJ cord-005453-4057qib7 15094 23 T t NN cord-005453-4057qib7 15094 24 cells cell NNS cord-005453-4057qib7 15094 25 isolated isolate VBN cord-005453-4057qib7 15094 26 from from IN cord-005453-4057qib7 15094 27 spleen spleen NN cord-005453-4057qib7 15094 28 , , , cord-005453-4057qib7 15094 29 blood blood NN cord-005453-4057qib7 15094 30 , , , cord-005453-4057qib7 15094 31 bone bone NN cord-005453-4057qib7 15094 32 marrow marrow NN cord-005453-4057qib7 15094 33 , , , cord-005453-4057qib7 15094 34 lymph lymph NN cord-005453-4057qib7 15094 35 nodes node NNS cord-005453-4057qib7 15094 36 , , , cord-005453-4057qib7 15094 37 liver liver NN cord-005453-4057qib7 15094 38 and and CC cord-005453-4057qib7 15094 39 lung lung NN cord-005453-4057qib7 15094 40 . . . cord-005453-4057qib7 15095 1 Cells cell NNS cord-005453-4057qib7 15095 2 were be VBD cord-005453-4057qib7 15095 3 stained stain VBN cord-005453-4057qib7 15095 4 for for IN cord-005453-4057qib7 15095 5 characteristic characteristic JJ cord-005453-4057qib7 15095 6 surface surface NN cord-005453-4057qib7 15095 7 and and CC cord-005453-4057qib7 15095 8 intracellular intracellular JJ cord-005453-4057qib7 15095 9 markers marker NNS cord-005453-4057qib7 15095 10 and and CC cord-005453-4057qib7 15095 11 characterized characterize VBN cord-005453-4057qib7 15095 12 by by IN cord-005453-4057qib7 15095 13 multiparametric multiparametric NNP cord-005453-4057qib7 15095 14 flowcytometric flowcytometric NNP cord-005453-4057qib7 15095 15 analysis analysis NN cord-005453-4057qib7 15095 16 . . . cord-005453-4057qib7 15096 1 CCR4 ccr4 JJ cord-005453-4057qib7 15096 2 expression expression NN cord-005453-4057qib7 15096 3 kinetics kinetics NN cord-005453-4057qib7 15096 4 following follow VBG cord-005453-4057qib7 15096 5 stimulation stimulation NN cord-005453-4057qib7 15096 6 were be VBD cord-005453-4057qib7 15096 7 analysed analyse VBN cord-005453-4057qib7 15096 8 in in IN cord-005453-4057qib7 15096 9 Tconv Tconv NNP cord-005453-4057qib7 15096 10 and and CC cord-005453-4057qib7 15096 11 Treg Treg NNP cord-005453-4057qib7 15096 12 isolated isolate VBN cord-005453-4057qib7 15096 13 from from IN cord-005453-4057qib7 15096 14 murine murine JJ cord-005453-4057qib7 15096 15 splenocytes splenocyte NNS cord-005453-4057qib7 15096 16 by by IN cord-005453-4057qib7 15096 17 FACS FACS NNP cord-005453-4057qib7 15096 18 and and CC cord-005453-4057qib7 15096 19 polyclonally polyclonally RB cord-005453-4057qib7 15096 20 activated activate VBN cord-005453-4057qib7 15096 21 by by IN cord-005453-4057qib7 15096 22 anti anti JJ cord-005453-4057qib7 15096 23 - - JJ cord-005453-4057qib7 15096 24 CD3 cd3 JJ cord-005453-4057qib7 15096 25 / / SYM cord-005453-4057qib7 15096 26 CD28-coated CD28-coated NNP cord-005453-4057qib7 15096 27 beads bead NNS cord-005453-4057qib7 15096 28 in in IN cord-005453-4057qib7 15096 29 the the DT cord-005453-4057qib7 15096 30 presence presence NN cord-005453-4057qib7 15096 31 of of IN cord-005453-4057qib7 15096 32 exogenous exogenous JJ cord-005453-4057qib7 15096 33 IL-2 IL-2 NNP cord-005453-4057qib7 15096 34 . . . cord-005453-4057qib7 15096 35 Expression expression NN cord-005453-4057qib7 15096 36 was be VBD cord-005453-4057qib7 15096 37 monitored monitor VBN cord-005453-4057qib7 15096 38 by by IN cord-005453-4057qib7 15096 39 daily daily JJ cord-005453-4057qib7 15096 40 flow flow NN cord-005453-4057qib7 15096 41 cytometric cytometric NNP cord-005453-4057qib7 15096 42 analysis analysis NN cord-005453-4057qib7 15096 43 . . . cord-005453-4057qib7 15097 1 CCR4 ccr4 NN cord-005453-4057qib7 15097 2 overexpression overexpression NN cord-005453-4057qib7 15097 3 was be VBD cord-005453-4057qib7 15097 4 induced induce VBN cord-005453-4057qib7 15097 5 by by IN cord-005453-4057qib7 15097 6 transduction transduction NN cord-005453-4057qib7 15097 7 of of IN cord-005453-4057qib7 15097 8 expanded expand VBN cord-005453-4057qib7 15097 9 Treg Treg NNP cord-005453-4057qib7 15097 10 with with IN cord-005453-4057qib7 15097 11 CCR4 CCR4 NNP cord-005453-4057qib7 15097 12 mRNA mRNA NNP cord-005453-4057qib7 15098 1 via via IN cord-005453-4057qib7 15098 2 electroporation electroporation NN cord-005453-4057qib7 15098 3 . . . cord-005453-4057qib7 15099 1 Expression expression NN cord-005453-4057qib7 15099 2 kinetics kinetic NNS cord-005453-4057qib7 15099 3 were be VBD cord-005453-4057qib7 15099 4 monitored monitor VBN cord-005453-4057qib7 15099 5 by by IN cord-005453-4057qib7 15099 6 FACS FACS NNP cord-005453-4057qib7 15099 7 , , , cord-005453-4057qib7 15099 8 receptor receptor NN cord-005453-4057qib7 15099 9 function function NN cord-005453-4057qib7 15099 10 was be VBD cord-005453-4057qib7 15099 11 tested test VBN cord-005453-4057qib7 15099 12 in in IN cord-005453-4057qib7 15099 13 transwell transwell NNP cord-005453-4057qib7 15099 14 migration migration NN cord-005453-4057qib7 15099 15 assays assay NNS cord-005453-4057qib7 15099 16 using use VBG cord-005453-4057qib7 15099 17 CCR4 CCR4 NNP cord-005453-4057qib7 15099 18 ligands ligand NNS cord-005453-4057qib7 15099 19 CCL-17 CCL-17 . cord-005453-4057qib7 15099 20 and and CC cord-005453-4057qib7 15099 21 CCL-22 CCL-22 NNP cord-005453-4057qib7 15099 22 . . . cord-005453-4057qib7 15100 1 Results result NNS cord-005453-4057qib7 15100 2 : : : cord-005453-4057qib7 15101 1 Systematic systematic JJ cord-005453-4057qib7 15101 2 analyses analysis NNS cord-005453-4057qib7 15101 3 showed show VBD cord-005453-4057qib7 15101 4 higher high JJR cord-005453-4057qib7 15101 5 CCR4 CCR4 NNP cord-005453-4057qib7 15101 6 expression expression NN cord-005453-4057qib7 15101 7 on on IN cord-005453-4057qib7 15101 8 memory memory NN cord-005453-4057qib7 15101 9 Treg Treg NNP cord-005453-4057qib7 15101 10 than than IN cord-005453-4057qib7 15101 11 on on IN cord-005453-4057qib7 15101 12 their -PRON- PRP$ cord-005453-4057qib7 15101 13 naive naive JJ cord-005453-4057qib7 15101 14 counterpart counterpart NN cord-005453-4057qib7 15101 15 in in IN cord-005453-4057qib7 15101 16 all all DT cord-005453-4057qib7 15101 17 examined examine VBN cord-005453-4057qib7 15101 18 organs organ NNS cord-005453-4057qib7 15101 19 with with IN cord-005453-4057qib7 15101 20 bone bone NN cord-005453-4057qib7 15101 21 marrow marrow NN cord-005453-4057qib7 15101 22 samples sample NNS cord-005453-4057qib7 15101 23 displaying display VBG cord-005453-4057qib7 15101 24 the the DT cord-005453-4057qib7 15101 25 greatest great JJS cord-005453-4057qib7 15101 26 disparity disparity NN cord-005453-4057qib7 15101 27 . . . cord-005453-4057qib7 15102 1 Memory Memory NNP cord-005453-4057qib7 15102 2 Treg Treg NNP cord-005453-4057qib7 15102 3 showed show VBD cord-005453-4057qib7 15102 4 higher high JJR cord-005453-4057qib7 15102 5 CCR4 CCR4 NNP cord-005453-4057qib7 15102 6 expression expression NN cord-005453-4057qib7 15102 7 than than IN cord-005453-4057qib7 15102 8 memory memory NN cord-005453-4057qib7 15102 9 Tconv Tconv NNP cord-005453-4057qib7 15102 10 in in IN cord-005453-4057qib7 15102 11 all all DT cord-005453-4057qib7 15102 12 analysed analyse VBN cord-005453-4057qib7 15102 13 organs organ NNS cord-005453-4057qib7 15102 14 , , , cord-005453-4057qib7 15102 15 except except IN cord-005453-4057qib7 15102 16 for for IN cord-005453-4057qib7 15102 17 lymph lymph NN cord-005453-4057qib7 15102 18 nodes node NNS cord-005453-4057qib7 15102 19 where where WRB cord-005453-4057qib7 15102 20 both both DT cord-005453-4057qib7 15102 21 memory memory NN cord-005453-4057qib7 15102 22 populations population NNS cord-005453-4057qib7 15102 23 revealed reveal VBD cord-005453-4057qib7 15102 24 equal equal JJ cord-005453-4057qib7 15102 25 expression expression NN cord-005453-4057qib7 15102 26 levels level NNS cord-005453-4057qib7 15102 27 . . . cord-005453-4057qib7 15103 1 Stimulation stimulation NN cord-005453-4057qib7 15103 2 of of IN cord-005453-4057qib7 15103 3 in in FW cord-005453-4057qib7 15103 4 vitro vitro FW cord-005453-4057qib7 15103 5 expanded expand VBD cord-005453-4057qib7 15103 6 Treg Treg NNP cord-005453-4057qib7 15103 7 and and CC cord-005453-4057qib7 15103 8 Tconv Tconv NNP cord-005453-4057qib7 15103 9 lead lead VBP cord-005453-4057qib7 15103 10 to to IN cord-005453-4057qib7 15103 11 a a DT cord-005453-4057qib7 15103 12 strong strong JJ cord-005453-4057qib7 15103 13 increase increase NN cord-005453-4057qib7 15103 14 in in IN cord-005453-4057qib7 15103 15 CCR4 CCR4 NNP cord-005453-4057qib7 15103 16 expression expression NN cord-005453-4057qib7 15103 17 with with IN cord-005453-4057qib7 15103 18 maximum maximum JJ cord-005453-4057qib7 15103 19 levels level NNS cord-005453-4057qib7 15103 20 on on IN cord-005453-4057qib7 15103 21 d3 d3 NNP cord-005453-4057qib7 15103 22 and and CC cord-005453-4057qib7 15103 23 d2 d2 NNP cord-005453-4057qib7 15103 24 respectively respectively RB cord-005453-4057qib7 15103 25 , , , cord-005453-4057qib7 15103 26 whereas whereas IN cord-005453-4057qib7 15103 27 restimulation restimulation NN cord-005453-4057qib7 15103 28 ( ( -LRB- cord-005453-4057qib7 15103 29 d7 d7 NNP cord-005453-4057qib7 15103 30 ) ) -RRB- cord-005453-4057qib7 15103 31 resulted result VBD cord-005453-4057qib7 15103 32 in in IN cord-005453-4057qib7 15103 33 no no DT cord-005453-4057qib7 15103 34 further further JJ cord-005453-4057qib7 15103 35 relevant relevant JJ cord-005453-4057qib7 15103 36 CCR4 CCR4 NNP cord-005453-4057qib7 15103 37 expression expression NN cord-005453-4057qib7 15103 38 on on IN cord-005453-4057qib7 15103 39 Treg Treg NNP cord-005453-4057qib7 15103 40 . . . cord-005453-4057qib7 15104 1 We -PRON- PRP cord-005453-4057qib7 15104 2 performed perform VBD cord-005453-4057qib7 15104 3 systematic systematic JJ cord-005453-4057qib7 15104 4 optimization optimization NN cord-005453-4057qib7 15104 5 of of IN cord-005453-4057qib7 15104 6 stimulation stimulation NN cord-005453-4057qib7 15104 7 and and CC cord-005453-4057qib7 15104 8 mRNA mrna NN cord-005453-4057qib7 15104 9 - - HYPH cord-005453-4057qib7 15104 10 electroporation electroporation NN cord-005453-4057qib7 15104 11 conditions condition NNS cord-005453-4057qib7 15104 12 to to TO cord-005453-4057qib7 15104 13 reliably reliably RB cord-005453-4057qib7 15104 14 achieve achieve VB cord-005453-4057qib7 15104 15 highlevel highlevel JJ cord-005453-4057qib7 15104 16 short short JJ cord-005453-4057qib7 15104 17 - - HYPH cord-005453-4057qib7 15104 18 term term NN cord-005453-4057qib7 15104 19 CCR4 CCR4 NNP cord-005453-4057qib7 15104 20 expression expression NN cord-005453-4057qib7 15104 21 . . . cord-005453-4057qib7 15105 1 Transduction transduction NN cord-005453-4057qib7 15105 2 of of IN cord-005453-4057qib7 15105 3 Treg Treg NNP cord-005453-4057qib7 15105 4 on on IN cord-005453-4057qib7 15105 5 d11 d11 NNP cord-005453-4057qib7 15105 6 of of IN cord-005453-4057qib7 15105 7 in in FW cord-005453-4057qib7 15105 8 vitro vitro FW cord-005453-4057qib7 15105 9 expansion expansion NN cord-005453-4057qib7 15105 10 resulted result VBD cord-005453-4057qib7 15105 11 in in IN cord-005453-4057qib7 15105 12 a a DT cord-005453-4057qib7 15105 13 strong strong JJ cord-005453-4057qib7 15105 14 CCR4 CCR4 NNP cord-005453-4057qib7 15105 15 expression expression NN cord-005453-4057qib7 15105 16 , , , cord-005453-4057qib7 15105 17 with with IN cord-005453-4057qib7 15105 18 maximum maximum JJ cord-005453-4057qib7 15105 19 levels level NNS cord-005453-4057qib7 15105 20 2h 2h CD cord-005453-4057qib7 15105 21 after after IN cord-005453-4057qib7 15105 22 electroporation electroporation NN cord-005453-4057qib7 15105 23 and and CC cord-005453-4057qib7 15105 24 strong strong JJ cord-005453-4057qib7 15105 25 CCR4 CCR4 NNP cord-005453-4057qib7 15105 26 expression expression NN cord-005453-4057qib7 15105 27 being be VBG cord-005453-4057qib7 15105 28 detectable detectable JJ cord-005453-4057qib7 15105 29 for for IN cord-005453-4057qib7 15105 30 at at IN cord-005453-4057qib7 15105 31 least least RBS cord-005453-4057qib7 15105 32 8h 8h CD cord-005453-4057qib7 15105 33 . . . cord-005453-4057qib7 15106 1 Transwell Transwell NNP cord-005453-4057qib7 15106 2 migration migration NN cord-005453-4057qib7 15106 3 assays assay NNS cord-005453-4057qib7 15106 4 showed show VBD cord-005453-4057qib7 15106 5 enhanced enhance VBN cord-005453-4057qib7 15106 6 migrational migrational JJ cord-005453-4057qib7 15106 7 properties property NNS cord-005453-4057qib7 15106 8 of of IN cord-005453-4057qib7 15106 9 mRNA mRNA NNP cord-005453-4057qib7 15106 10 - - HYPH cord-005453-4057qib7 15106 11 electroporated electroporate VBN cord-005453-4057qib7 15106 12 Treg Treg NNP cord-005453-4057qib7 15106 13 towards towards IN cord-005453-4057qib7 15106 14 CCR4 CCR4 NNP cord-005453-4057qib7 15106 15 ligands ligand NNS cord-005453-4057qib7 15106 16 . . . cord-005453-4057qib7 15107 1 Analyses analysis NNS cord-005453-4057qib7 15107 2 performed perform VBD cord-005453-4057qib7 15107 3 2h 2h CD cord-005453-4057qib7 15107 4 and and CC cord-005453-4057qib7 15107 5 16h 16h CD cord-005453-4057qib7 15107 6 after after IN cord-005453-4057qib7 15107 7 electroporation electroporation NN cord-005453-4057qib7 15107 8 showed show VBD cord-005453-4057qib7 15107 9 persistent persistent JJ cord-005453-4057qib7 15107 10 migration migration NN cord-005453-4057qib7 15107 11 even even RB cord-005453-4057qib7 15107 12 though though IN cord-005453-4057qib7 15107 13 measured measure VBN cord-005453-4057qib7 15107 14 CCR4 CCR4 NNP cord-005453-4057qib7 15107 15 surface surface NN cord-005453-4057qib7 15107 16 expression expression NN cord-005453-4057qib7 15107 17 had have VBD cord-005453-4057qib7 15107 18 already already RB cord-005453-4057qib7 15107 19 declined decline VBN cord-005453-4057qib7 15107 20 significantly significantly RB cord-005453-4057qib7 15107 21 . . . cord-005453-4057qib7 15108 1 Conclusions conclusion NNS cord-005453-4057qib7 15108 2 : : : cord-005453-4057qib7 15109 1 We -PRON- PRP cord-005453-4057qib7 15109 2 showed show VBD cord-005453-4057qib7 15109 3 that that IN cord-005453-4057qib7 15109 4 high high JJ cord-005453-4057qib7 15109 5 CCR4 CCR4 NNP cord-005453-4057qib7 15109 6 expression expression NN cord-005453-4057qib7 15109 7 can can MD cord-005453-4057qib7 15109 8 be be VB cord-005453-4057qib7 15109 9 detected detect VBN cord-005453-4057qib7 15109 10 on on IN cord-005453-4057qib7 15109 11 memory memory NN cord-005453-4057qib7 15109 12 Treg Treg NNP cord-005453-4057qib7 15109 13 in in IN cord-005453-4057qib7 15109 14 all all DT cord-005453-4057qib7 15109 15 analysed analyse VBN cord-005453-4057qib7 15109 16 organs organ NNS cord-005453-4057qib7 15109 17 . . . cord-005453-4057qib7 15110 1 Since since IN cord-005453-4057qib7 15110 2 in in IN cord-005453-4057qib7 15110 3 vitro vitro FW cord-005453-4057qib7 15110 4 stimulation stimulation NN cord-005453-4057qib7 15110 5 of of IN cord-005453-4057qib7 15110 6 murine murine JJ cord-005453-4057qib7 15110 7 Treg Treg NNP cord-005453-4057qib7 15110 8 did do VBD cord-005453-4057qib7 15110 9 not not RB cord-005453-4057qib7 15110 10 reliably reliably RB cord-005453-4057qib7 15110 11 induce induce VB cord-005453-4057qib7 15110 12 CCR4 CCR4 NNP cord-005453-4057qib7 15110 13 expression expression NN cord-005453-4057qib7 15110 14 , , , cord-005453-4057qib7 15110 15 we -PRON- PRP cord-005453-4057qib7 15110 16 established establish VBD cord-005453-4057qib7 15110 17 a a DT cord-005453-4057qib7 15110 18 protocol protocol NN cord-005453-4057qib7 15110 19 for for IN cord-005453-4057qib7 15110 20 CCR4 CCR4 NNP cord-005453-4057qib7 15110 21 mRNA mrna NN cord-005453-4057qib7 15110 22 - - HYPH cord-005453-4057qib7 15110 23 electroporation electroporation NN cord-005453-4057qib7 15110 24 . . . cord-005453-4057qib7 15111 1 Electroporated Electroporated NNP cord-005453-4057qib7 15111 2 cells cell NNS cord-005453-4057qib7 15111 3 showed show VBD cord-005453-4057qib7 15111 4 stable stable JJ cord-005453-4057qib7 15111 5 short short JJ cord-005453-4057qib7 15111 6 - - HYPH cord-005453-4057qib7 15111 7 term term NN cord-005453-4057qib7 15111 8 CCR4 CCR4 NNP cord-005453-4057qib7 15111 9 expression expression NN cord-005453-4057qib7 15111 10 and and CC cord-005453-4057qib7 15111 11 enhanced enhanced JJ cord-005453-4057qib7 15111 12 migrational migrational JJ cord-005453-4057qib7 15111 13 properties property NNS cord-005453-4057qib7 15111 14 towards towards IN cord-005453-4057qib7 15111 15 CCR4 CCR4 NNP cord-005453-4057qib7 15111 16 ligands ligand NNS cord-005453-4057qib7 15111 17 in in IN cord-005453-4057qib7 15111 18 vitro vitro FW cord-005453-4057qib7 15111 19 . . . cord-005453-4057qib7 15112 1 Future future JJ cord-005453-4057qib7 15112 2 studies study NNS cord-005453-4057qib7 15112 3 will will MD cord-005453-4057qib7 15112 4 show show VB cord-005453-4057qib7 15112 5 whether whether IN cord-005453-4057qib7 15112 6 the the DT cord-005453-4057qib7 15112 7 induction induction NN cord-005453-4057qib7 15112 8 of of IN cord-005453-4057qib7 15112 9 short short JJ cord-005453-4057qib7 15112 10 - - HYPH cord-005453-4057qib7 15112 11 term term NN cord-005453-4057qib7 15112 12 CCR4 CCR4 NNP cord-005453-4057qib7 15112 13 expression expression NN cord-005453-4057qib7 15112 14 will will MD cord-005453-4057qib7 15112 15 facilitate facilitate VB cord-005453-4057qib7 15112 16 in in IN cord-005453-4057qib7 15112 17 vivo vivo NN cord-005453-4057qib7 15112 18 homing homing NN cord-005453-4057qib7 15112 19 of of IN cord-005453-4057qib7 15112 20 adoptively adoptively RB cord-005453-4057qib7 15112 21 transferred transfer VBN cord-005453-4057qib7 15112 22 Treg Treg NNP cord-005453-4057qib7 15112 23 to to IN cord-005453-4057qib7 15112 24 sites site NNS cord-005453-4057qib7 15112 25 of of IN cord-005453-4057qib7 15112 26 ongoing ongoing JJ cord-005453-4057qib7 15112 27 GVHD GVHD NNP cord-005453-4057qib7 15112 28 and and CC cord-005453-4057qib7 15112 29 thus thus RB cord-005453-4057qib7 15112 30 mediate mediate VB cord-005453-4057qib7 15112 31 long long JJ cord-005453-4057qib7 15112 32 - - HYPH cord-005453-4057qib7 15112 33 term term NN cord-005453-4057qib7 15112 34 inflammation inflammation NN cord-005453-4057qib7 15112 35 suppression suppression NN cord-005453-4057qib7 15112 36 . . . cord-005453-4057qib7 15113 1 Disclosure disclosure NN cord-005453-4057qib7 15113 2 : : : cord-005453-4057qib7 15114 1 The the DT cord-005453-4057qib7 15114 2 authors author NNS cord-005453-4057qib7 15114 3 have have VBP cord-005453-4057qib7 15114 4 no no DT cord-005453-4057qib7 15114 5 conflict conflict NN cord-005453-4057qib7 15114 6 to to TO cord-005453-4057qib7 15114 7 disclose disclose VB cord-005453-4057qib7 15114 8 . . . cord-005453-4057qib7 15115 1 Survival survival NN cord-005453-4057qib7 15115 2 and and CC cord-005453-4057qib7 15115 3 immune immune JJ cord-005453-4057qib7 15115 4 reconstitution reconstitution NN cord-005453-4057qib7 15115 5 of of IN cord-005453-4057qib7 15115 6 syngeneic syngeneic NNS cord-005453-4057qib7 15115 7 , , , cord-005453-4057qib7 15115 8 haploidentical haploidentical JJ cord-005453-4057qib7 15115 9 and and CC cord-005453-4057qib7 15115 10 allogeneic allogeneic IN cord-005453-4057qib7 15115 11 hematopoietic hematopoietic JJ cord-005453-4057qib7 15115 12 stem stem NN cord-005453-4057qib7 15115 13 cell cell NN cord-005453-4057qib7 15115 14 transplantation transplantation NN cord-005453-4057qib7 15115 15 in in IN cord-005453-4057qib7 15115 16 ATM atm NN cord-005453-4057qib7 15115 17 - - HYPH cord-005453-4057qib7 15115 18 deficient deficient JJ cord-005453-4057qib7 15115 19 mice mouse NNS cord-005453-4057qib7 15115 20 Ruth Ruth NNP cord-005453-4057qib7 15115 21 Pia Pia NNP cord-005453-4057qib7 15115 22 Duecker Duecker NNP cord-005453-4057qib7 15115 23 1 1 CD cord-005453-4057qib7 15115 24 , , , cord-005453-4057qib7 15115 25 Patrick Patrick NNP cord-005453-4057qib7 15115 26 C. C. NNP cord-005453-4057qib7 15115 27 Baer Baer NNP cord-005453-4057qib7 15115 28 2 2 CD cord-005453-4057qib7 15115 29 , , , cord-005453-4057qib7 15115 30 Stefan Stefan NNP cord-005453-4057qib7 15115 31 Zielen Zielen NNP cord-005453-4057qib7 15115 32 1 1 CD cord-005453-4057qib7 15115 33 , , , cord-005453-4057qib7 15115 34 Ralf Ralf NNP cord-005453-4057qib7 15115 35 Schubert Schubert NNP cord-005453-4057qib7 15115 36 1 1 CD cord-005453-4057qib7 15115 37 from from IN cord-005453-4057qib7 15115 38 allo allo NN cord-005453-4057qib7 15115 39 - - HYPH cord-005453-4057qib7 15115 40 HSCT HSCT NNP cord-005453-4057qib7 15115 41 . . . cord-005453-4057qib7 15116 1 It´s It´s NNP cord-005453-4057qib7 15116 2 not not RB cord-005453-4057qib7 15116 3 necessary necessary JJ cord-005453-4057qib7 15116 4 to to TO cord-005453-4057qib7 15116 5 do do VB cord-005453-4057qib7 15116 6 chemotherapy chemotherapy NN cord-005453-4057qib7 15116 7 before before IN cord-005453-4057qib7 15116 8 transplantation transplantation NN cord-005453-4057qib7 15116 9 for for IN cord-005453-4057qib7 15116 10 patients patient NNS cord-005453-4057qib7 15116 11 with with IN cord-005453-4057qib7 15116 12 bone bone NN cord-005453-4057qib7 15116 13 marrow marrow NN cord-005453-4057qib7 15116 14 blast blast NN cord-005453-4057qib7 15116 15 cells cell NNS cord-005453-4057qib7 15116 16 more more JJR cord-005453-4057qib7 15116 17 than than IN cord-005453-4057qib7 15116 18 10 10 CD cord-005453-4057qib7 15116 19 % % NN cord-005453-4057qib7 15116 20 at at IN cord-005453-4057qib7 15116 21 the the DT cord-005453-4057qib7 15116 22 time time NN cord-005453-4057qib7 15116 23 of of IN cord-005453-4057qib7 15116 24 diagnosis diagnosis NN cord-005453-4057qib7 15116 25 . . . cord-005453-4057qib7 15117 1 [ [ -LRB- cord-005453-4057qib7 15117 2 [ [ -LRB- cord-005453-4057qib7 15117 3 P738 P738 NNP cord-005453-4057qib7 15117 4 Image image NN cord-005453-4057qib7 15117 5 ] ] -RRB- cord-005453-4057qib7 15117 6 1 1 CD cord-005453-4057qib7 15117 7 . . . cord-005453-4057qib7 15118 1 Figure figure NN cord-005453-4057qib7 15118 2 1 1 CD cord-005453-4057qib7 15119 1 The the DT cord-005453-4057qib7 15119 2 HCI HCI NNP cord-005453-4057qib7 15119 3 - - HYPH cord-005453-4057qib7 15119 4 CT CT NNP cord-005453-4057qib7 15119 5 of of IN cord-005453-4057qib7 15119 6 patients patient NNS cord-005453-4057qib7 15119 7 before before IN cord-005453-4057qib7 15119 8 transplantation transplantation NN cord-005453-4057qib7 15119 9 and and CC cord-005453-4057qib7 15119 10 occurance occurance NN cord-005453-4057qib7 15119 11 of of IN cord-005453-4057qib7 15119 12 grade grade NN cord-005453-4057qib7 15119 13 III III NNP cord-005453-4057qib7 15119 14 - - HYPH cord-005453-4057qib7 15119 15 IV IV NNP cord-005453-4057qib7 15119 16 aGVHD agvhd NN cord-005453-4057qib7 15119 17 on on IN cord-005453-4057qib7 15119 18 overall overall JJ cord-005453-4057qib7 15119 19 surviv surviv NN cord-005453-4057qib7 15119 20 ] ] -RRB- cord-005453-4057qib7 15120 1 Background background NN cord-005453-4057qib7 15120 2 : : : cord-005453-4057qib7 15120 3 1 1 CD cord-005453-4057qib7 15120 4 . . . cord-005453-4057qib7 15121 1 Allogeneic allogeneic IN cord-005453-4057qib7 15121 2 haematopoietic haematopoietic JJ cord-005453-4057qib7 15121 3 stem stem NN cord-005453-4057qib7 15121 4 cell cell NN cord-005453-4057qib7 15121 5 transplantation transplantation NN cord-005453-4057qib7 15121 6 ( ( -LRB- cord-005453-4057qib7 15121 7 SCT SCT NNP cord-005453-4057qib7 15121 8 ) ) -RRB- cord-005453-4057qib7 15121 9 offers offer VBZ cord-005453-4057qib7 15121 10 the the DT cord-005453-4057qib7 15121 11 chance chance NN cord-005453-4057qib7 15121 12 of of IN cord-005453-4057qib7 15121 13 cure cure NN cord-005453-4057qib7 15121 14 for for IN cord-005453-4057qib7 15121 15 patients patient NNS cord-005453-4057qib7 15121 16 with with IN cord-005453-4057qib7 15121 17 transfusion transfusion NN cord-005453-4057qib7 15121 18 - - HYPH cord-005453-4057qib7 15121 19 dependent dependent JJ cord-005453-4057qib7 15121 20 thalassemia thalassemia NN cord-005453-4057qib7 15121 21 ( ( -LRB- cord-005453-4057qib7 15121 22 TDT TDT NNP cord-005453-4057qib7 15121 23 ) ) -RRB- cord-005453-4057qib7 15121 24 . . . cord-005453-4057qib7 15122 1 Based base VBN cord-005453-4057qib7 15122 2 on on IN cord-005453-4057qib7 15122 3 the the DT cord-005453-4057qib7 15122 4 non non JJ cord-005453-4057qib7 15122 5 - - JJ cord-005453-4057qib7 15122 6 neoplastic neoplastic JJ cord-005453-4057qib7 15122 7 nature nature NN cord-005453-4057qib7 15122 8 of of IN cord-005453-4057qib7 15122 9 this this DT cord-005453-4057qib7 15122 10 condition condition NN cord-005453-4057qib7 15122 11 SCT SCT NNP cord-005453-4057qib7 15122 12 approaches approach NNS cord-005453-4057qib7 15122 13 urgently urgently RB cord-005453-4057qib7 15122 14 require require VBP cord-005453-4057qib7 15122 15 to to TO cord-005453-4057qib7 15122 16 prove prove VB cord-005453-4057qib7 15122 17 both both DT cord-005453-4057qib7 15122 18 efficacious efficacious JJ cord-005453-4057qib7 15122 19 and and CC cord-005453-4057qib7 15122 20 safe safe JJ cord-005453-4057qib7 15122 21 . . . cord-005453-4057qib7 15123 1 Methods method NNS cord-005453-4057qib7 15123 2 : : : cord-005453-4057qib7 15123 3 2 2 CD cord-005453-4057qib7 15123 4 . . . cord-005453-4057qib7 15124 1 We -PRON- PRP cord-005453-4057qib7 15124 2 report report VBP cord-005453-4057qib7 15124 3 on on IN cord-005453-4057qib7 15124 4 13 13 CD cord-005453-4057qib7 15124 5 children child NNS cord-005453-4057qib7 15124 6 , , , cord-005453-4057qib7 15124 7 adolescents adolescent NNS cord-005453-4057qib7 15124 8 and and CC cord-005453-4057qib7 15124 9 young young JJ cord-005453-4057qib7 15124 10 adults adult NNS cord-005453-4057qib7 15124 11 ( ( -LRB- cord-005453-4057qib7 15124 12 median median JJ cord-005453-4057qib7 15124 13 age age NN cord-005453-4057qib7 15124 14 : : : cord-005453-4057qib7 15124 15 6 6 CD cord-005453-4057qib7 15124 16 years year NNS cord-005453-4057qib7 15124 17 ; ; : cord-005453-4057qib7 15124 18 range range VBP cord-005453-4057qib7 15124 19 2 2 CD cord-005453-4057qib7 15124 20 - - SYM cord-005453-4057qib7 15124 21 28 28 CD cord-005453-4057qib7 15124 22 years year NNS cord-005453-4057qib7 15124 23 ) ) -RRB- cord-005453-4057qib7 15124 24 with with IN cord-005453-4057qib7 15124 25 TDT TDT NNP cord-005453-4057qib7 15124 26 receiving receive VBG cord-005453-4057qib7 15124 27 SCT SCT NNP cord-005453-4057qib7 15124 28 from from IN cord-005453-4057qib7 15124 29 an an DT cord-005453-4057qib7 15124 30 HLA HLA NNP cord-005453-4057qib7 15124 31 - - HYPH cord-005453-4057qib7 15124 32 matched match VBN cord-005453-4057qib7 15124 33 donor donor NN cord-005453-4057qib7 15124 34 ( ( -LRB- cord-005453-4057qib7 15124 35 MUD mud NN cord-005453-4057qib7 15124 36 n=8 n=8 NN cord-005453-4057qib7 15124 37 , , , cord-005453-4057qib7 15124 38 MSD MSD NNP cord-005453-4057qib7 15124 39 n=3 n=3 NN cord-005453-4057qib7 15124 40 , , , cord-005453-4057qib7 15124 41 MFD MFD NNP cord-005453-4057qib7 15124 42 n=2 n=2 NNS cord-005453-4057qib7 15124 43 ) ) -RRB- cord-005453-4057qib7 15124 44 in in IN cord-005453-4057qib7 15124 45 our -PRON- PRP$ cord-005453-4057qib7 15124 46 center center NN cord-005453-4057qib7 15124 47 from from IN cord-005453-4057qib7 15124 48 2011 2011 CD cord-005453-4057qib7 15124 49 - - SYM cord-005453-4057qib7 15124 50 2017 2017 CD cord-005453-4057qib7 15124 51 . . . cord-005453-4057qib7 15125 1 All all DT cord-005453-4057qib7 15125 2 patients patient NNS cord-005453-4057qib7 15125 3 received receive VBD cord-005453-4057qib7 15125 4 the the DT cord-005453-4057qib7 15125 5 same same JJ cord-005453-4057qib7 15125 6 treosulfan treosulfan NN cord-005453-4057qib7 15125 7 - - HYPH cord-005453-4057qib7 15125 8 based base VBN cord-005453-4057qib7 15125 9 conditioning conditioning NN cord-005453-4057qib7 15125 10 regimen regimen NN cord-005453-4057qib7 15125 11 ( ( -LRB- cord-005453-4057qib7 15125 12 treosulfan treosulfan NNP cord-005453-4057qib7 15125 13 3x14g 3x14g NNP cord-005453-4057qib7 15125 14 / / SYM cord-005453-4057qib7 15125 15 m2 m2 NNP cord-005453-4057qib7 15125 16 , , , cord-005453-4057qib7 15125 17 fludarabine fludarabine NNP cord-005453-4057qib7 15125 18 4x40mg 4x40mg CD cord-005453-4057qib7 15125 19 / / SYM cord-005453-4057qib7 15125 20 m2 m2 NNP cord-005453-4057qib7 15125 21 , , , cord-005453-4057qib7 15125 22 thiotepa thiotepa JJ cord-005453-4057qib7 15125 23 1x8mg 1x8mg CD cord-005453-4057qib7 15125 24 / / SYM cord-005453-4057qib7 15125 25 kg kg NNP cord-005453-4057qib7 15125 26 ) ) -RRB- cord-005453-4057qib7 15125 27 . . . cord-005453-4057qib7 15126 1 GvHD GvHD NNP cord-005453-4057qib7 15126 2 prophylaxis prophylaxis NN cord-005453-4057qib7 15126 3 was be VBD cord-005453-4057qib7 15126 4 based base VBN cord-005453-4057qib7 15126 5 on on IN cord-005453-4057qib7 15126 6 ATG ATG NNP cord-005453-4057qib7 15126 7 - - HYPH cord-005453-4057qib7 15126 8 Fresenius Fresenius NNP cord-005453-4057qib7 15126 9 ™ ™ , cord-005453-4057qib7 15126 10 ( ( -LRB- cord-005453-4057qib7 15126 11 3x10mg 3x10mg NNS cord-005453-4057qib7 15126 12 / / SYM cord-005453-4057qib7 15126 13 kg kg NNS cord-005453-4057qib7 15126 14 , , , cord-005453-4057qib7 15126 15 if if IN cord-005453-4057qib7 15126 16 MUD mud NN cord-005453-4057qib7 15126 17 or or CC cord-005453-4057qib7 15126 18 MFD MFD NNP cord-005453-4057qib7 15126 19 as as IN cord-005453-4057qib7 15126 20 donor donor NN cord-005453-4057qib7 15126 21 ) ) -RRB- cord-005453-4057qib7 15126 22 , , , cord-005453-4057qib7 15126 23 CSA CSA NNP cord-005453-4057qib7 15126 24 ( ( -LRB- cord-005453-4057qib7 15126 25 with with IN cord-005453-4057qib7 15126 26 taper taper NN cord-005453-4057qib7 15126 27 from from IN cord-005453-4057qib7 15126 28 day day NN cord-005453-4057qib7 15126 29 +270 +270 NNP cord-005453-4057qib7 15126 30 ) ) -RRB- cord-005453-4057qib7 15126 31 as as RB cord-005453-4057qib7 15126 32 well well RB cord-005453-4057qib7 15126 33 as as IN cord-005453-4057qib7 15126 34 MTX MTX NNP cord-005453-4057qib7 15126 35 ( ( -LRB- cord-005453-4057qib7 15126 36 day day NN cord-005453-4057qib7 15126 37 1,3,6,11 1,3,6,11 CD cord-005453-4057qib7 15126 38 ) ) -RRB- cord-005453-4057qib7 15126 39 in in IN cord-005453-4057qib7 15126 40 9/13 9/13 CD cord-005453-4057qib7 15126 41 and and CC cord-005453-4057qib7 15126 42 MMF mmf NN cord-005453-4057qib7 15126 43 in in IN cord-005453-4057qib7 15126 44 4/13 4/13 CD cord-005453-4057qib7 15126 45 patients patient NNS cord-005453-4057qib7 15126 46 with with IN cord-005453-4057qib7 15126 47 MTX MTX NNP cord-005453-4057qib7 15126 48 toxicity toxicity NN cord-005453-4057qib7 15126 49 , , , cord-005453-4057qib7 15126 50 respectively respectively RB cord-005453-4057qib7 15126 51 . . . cord-005453-4057qib7 15127 1 Stem stem JJ cord-005453-4057qib7 15127 2 cell cell NN cord-005453-4057qib7 15127 3 source source NN cord-005453-4057qib7 15127 4 was be VBD cord-005453-4057qib7 15127 5 bone bone NN cord-005453-4057qib7 15127 6 marrow marrow NN cord-005453-4057qib7 15127 7 in in IN cord-005453-4057qib7 15127 8 8 8 CD cord-005453-4057qib7 15127 9 , , , cord-005453-4057qib7 15127 10 peripheral peripheral JJ cord-005453-4057qib7 15127 11 blood blood NN cord-005453-4057qib7 15127 12 stem stem NN cord-005453-4057qib7 15127 13 cells cell NNS cord-005453-4057qib7 15127 14 in in IN cord-005453-4057qib7 15127 15 4 4 CD cord-005453-4057qib7 15127 16 and and CC cord-005453-4057qib7 15127 17 cord cord NN cord-005453-4057qib7 15127 18 blood blood NN cord-005453-4057qib7 15127 19 in in IN cord-005453-4057qib7 15127 20 1 1 CD cord-005453-4057qib7 15127 21 patient patient NN cord-005453-4057qib7 15127 22 . . . cord-005453-4057qib7 15128 1 Prior prior RB cord-005453-4057qib7 15128 2 to to IN cord-005453-4057qib7 15128 3 transplantation transplantation NN cord-005453-4057qib7 15128 4 6 6 CD cord-005453-4057qib7 15128 5 children child NNS cord-005453-4057qib7 15128 6 received receive VBD cord-005453-4057qib7 15128 7 cytoreductive cytoreductive JJ cord-005453-4057qib7 15128 8 treatment treatment NN cord-005453-4057qib7 15128 9 with with IN cord-005453-4057qib7 15128 10 azathioprine azathioprine NN cord-005453-4057qib7 15128 11 , , , cord-005453-4057qib7 15128 12 hydroxycarbamide hydroxycarbamide NN cord-005453-4057qib7 15128 13 and and CC cord-005453-4057qib7 15128 14 intensified intensify VBD cord-005453-4057qib7 15128 15 erythrocyte erythrocyte NN cord-005453-4057qib7 15128 16 transfusion transfusion NN cord-005453-4057qib7 15128 17 . . . cord-005453-4057qib7 15129 1 Iron iron NN cord-005453-4057qib7 15129 2 elimination elimination NN cord-005453-4057qib7 15129 3 therapy therapy NN cord-005453-4057qib7 15129 4 was be VBD cord-005453-4057qib7 15129 5 carried carry VBN cord-005453-4057qib7 15129 6 out out RP cord-005453-4057qib7 15129 7 in in IN cord-005453-4057qib7 15129 8 12/13 12/13 CD cord-005453-4057qib7 15129 9 children child NNS cord-005453-4057qib7 15129 10 with with IN cord-005453-4057qib7 15129 11 deferasirox deferasirox NNP cord-005453-4057qib7 15129 12 . . . cord-005453-4057qib7 15130 1 Among among IN cord-005453-4057qib7 15130 2 the the DT cord-005453-4057qib7 15130 3 11 11 CD cord-005453-4057qib7 15130 4 patients patient NNS cord-005453-4057qib7 15130 5 with with IN cord-005453-4057qib7 15130 6 available available JJ cord-005453-4057qib7 15130 7 Ferris Ferris NNP cord-005453-4057qib7 15130 8 - - HYPH cord-005453-4057qib7 15130 9 can can MD cord-005453-4057qib7 15130 10 ™ ™ VB cord-005453-4057qib7 15130 11 analysis analysis NN cord-005453-4057qib7 15130 12 4 4 CD cord-005453-4057qib7 15130 13 patients patient NNS cord-005453-4057qib7 15130 14 showed show VBD cord-005453-4057qib7 15130 15 substantial substantial JJ cord-005453-4057qib7 15130 16 liver liver NN cord-005453-4057qib7 15130 17 iron iron NN cord-005453-4057qib7 15130 18 overload overload NN cord-005453-4057qib7 15130 19 ( ( -LRB- cord-005453-4057qib7 15130 20 liver liver NN cord-005453-4057qib7 15130 21 iron iron NN cord-005453-4057qib7 15130 22 > > XX cord-005453-4057qib7 15130 23 8mg 8mg NNP cord-005453-4057qib7 15130 24 / / SYM cord-005453-4057qib7 15130 25 g g NN cord-005453-4057qib7 15130 26 ) ) -RRB- cord-005453-4057qib7 15130 27 despite despite IN cord-005453-4057qib7 15130 28 intensive intensive JJ cord-005453-4057qib7 15130 29 chelation chelation NN cord-005453-4057qib7 15130 30 prior prior RB cord-005453-4057qib7 15130 31 to to IN cord-005453-4057qib7 15130 32 SCT SCT NNP cord-005453-4057qib7 15130 33 . . . cord-005453-4057qib7 15131 1 Results result NNS cord-005453-4057qib7 15131 2 : : : cord-005453-4057qib7 15131 3 3 3 CD cord-005453-4057qib7 15131 4 . . . cord-005453-4057qib7 15132 1 All all DT cord-005453-4057qib7 15132 2 patients patient NNS cord-005453-4057qib7 15132 3 achieved achieve VBD cord-005453-4057qib7 15132 4 leukocyte leukocyte NN cord-005453-4057qib7 15132 5 engraftment engraftment NN cord-005453-4057qib7 15132 6 at at IN cord-005453-4057qib7 15132 7 median median JJ cord-005453-4057qib7 15132 8 day day NN cord-005453-4057qib7 15132 9 +23 +23 CD cord-005453-4057qib7 15133 1 ( ( -LRB- cord-005453-4057qib7 15133 2 range range NNP cord-005453-4057qib7 15133 3 15 15 CD cord-005453-4057qib7 15133 4 - - SYM cord-005453-4057qib7 15133 5 39 39 CD cord-005453-4057qib7 15133 6 ) ) -RRB- cord-005453-4057qib7 15133 7 , , , cord-005453-4057qib7 15133 8 however however RB cord-005453-4057qib7 15133 9 two two CD cord-005453-4057qib7 15133 10 patients patient NNS cord-005453-4057qib7 15133 11 required require VBD cord-005453-4057qib7 15133 12 a a DT cord-005453-4057qib7 15133 13 CD34-selected CD34-selected NNP cord-005453-4057qib7 15133 14 PBSC PBSC NNP cord-005453-4057qib7 15133 15 boost boost NN cord-005453-4057qib7 15133 16 on on IN cord-005453-4057qib7 15133 17 day day NN cord-005453-4057qib7 15133 18 + + SYM cord-005453-4057qib7 15133 19 36 36 CD cord-005453-4057qib7 15133 20 and and CC cord-005453-4057qib7 15133 21 day day NN cord-005453-4057qib7 15133 22 +50 +50 NN cord-005453-4057qib7 15133 23 based base VBN cord-005453-4057qib7 15133 24 on on IN cord-005453-4057qib7 15133 25 delayed delay VBN cord-005453-4057qib7 15133 26 platelet platelet NN cord-005453-4057qib7 15133 27 and/or and/or CC cord-005453-4057qib7 15133 28 erythrocyte erythrocyte NN cord-005453-4057qib7 15133 29 engraftment engraftment NN cord-005453-4057qib7 15133 30 . . . cord-005453-4057qib7 15134 1 Nine nine CD cord-005453-4057qib7 15134 2 patients patient NNS cord-005453-4057qib7 15134 3 exhibited exhibit VBD cord-005453-4057qib7 15134 4 full full JJ cord-005453-4057qib7 15134 5 donor donor NN cord-005453-4057qib7 15134 6 chimerism chimerism NN cord-005453-4057qib7 15134 7 in in IN cord-005453-4057qib7 15134 8 the the DT cord-005453-4057qib7 15134 9 BM BM NNP cord-005453-4057qib7 15134 10 at at IN cord-005453-4057qib7 15134 11 day day NN cord-005453-4057qib7 15134 12 +30 +30 CD cord-005453-4057qib7 15134 13 , , , cord-005453-4057qib7 15134 14 the the DT cord-005453-4057qib7 15134 15 other other JJ cord-005453-4057qib7 15134 16 4 4 CD cord-005453-4057qib7 15134 17 showed show VBD cord-005453-4057qib7 15134 18 mixed mixed JJ cord-005453-4057qib7 15134 19 chimerism chimerism NN cord-005453-4057qib7 15134 20 with with IN cord-005453-4057qib7 15134 21 < < XX cord-005453-4057qib7 15134 22 5 5 CD cord-005453-4057qib7 15134 23 % % NN cord-005453-4057qib7 15134 24 autologous autologous JJ cord-005453-4057qib7 15134 25 cells cell NNS cord-005453-4057qib7 15134 26 . . . cord-005453-4057qib7 15135 1 On on IN cord-005453-4057qib7 15135 2 day day NN cord-005453-4057qib7 15135 3 +360 +360 NN cord-005453-4057qib7 15135 4 peripheral peripheral JJ cord-005453-4057qib7 15135 5 blood blood NN cord-005453-4057qib7 15135 6 chimerism chimerism NN cord-005453-4057qib7 15135 7 was be VBD cord-005453-4057qib7 15135 8 complete complete JJ cord-005453-4057qib7 15135 9 in in IN cord-005453-4057qib7 15135 10 12/13 12/13 CD cord-005453-4057qib7 15135 11 patients patient NNS cord-005453-4057qib7 15135 12 with with IN cord-005453-4057qib7 15135 13 the the DT cord-005453-4057qib7 15135 14 remaining remain VBG cord-005453-4057qib7 15135 15 patient patient NN cord-005453-4057qib7 15135 16 exhibiting exhibit VBG cord-005453-4057qib7 15135 17 stable stable JJ cord-005453-4057qib7 15135 18 split split NN cord-005453-4057qib7 15135 19 chimerism chimerism NN cord-005453-4057qib7 15135 20 with with IN cord-005453-4057qib7 15135 21 100 100 CD cord-005453-4057qib7 15135 22 % % NN cord-005453-4057qib7 15135 23 donor donor NN cord-005453-4057qib7 15135 24 - - HYPH cord-005453-4057qib7 15135 25 derived derive VBN cord-005453-4057qib7 15135 26 erythrocytes erythrocyte NNS cord-005453-4057qib7 15135 27 and and CC cord-005453-4057qib7 15135 28 60 60 CD cord-005453-4057qib7 15135 29 - - SYM cord-005453-4057qib7 15135 30 80 80 CD cord-005453-4057qib7 15135 31 % % NN cord-005453-4057qib7 15135 32 autologous autologous JJ cord-005453-4057qib7 15135 33 myeloid myeloid NN cord-005453-4057qib7 15135 34 cells cell NNS cord-005453-4057qib7 15135 35 . . . cord-005453-4057qib7 15136 1 Acute acute JJ cord-005453-4057qib7 15136 2 GvHD GvHD NNP cord-005453-4057qib7 15136 3 was be VBD cord-005453-4057qib7 15136 4 observed observe VBN cord-005453-4057qib7 15136 5 in in IN cord-005453-4057qib7 15136 6 three three CD cord-005453-4057qib7 15136 7 patients patient NNS cord-005453-4057qib7 15136 8 ( ( -LRB- cord-005453-4057qib7 15136 9 grade grade NN cord-005453-4057qib7 15136 10 2 2 CD cord-005453-4057qib7 15136 11 : : : cord-005453-4057qib7 15136 12 n=1 n=1 UH cord-005453-4057qib7 15136 13 , , , cord-005453-4057qib7 15136 14 grade grade NN cord-005453-4057qib7 15136 15 3 3 CD cord-005453-4057qib7 15136 16 : : : cord-005453-4057qib7 15136 17 n=2 n=2 NNS cord-005453-4057qib7 15136 18 ) ) -RRB- cord-005453-4057qib7 15136 19 . . . cord-005453-4057qib7 15137 1 However however RB cord-005453-4057qib7 15137 2 , , , cord-005453-4057qib7 15137 3 all all DT cord-005453-4057qib7 15137 4 patients patient NNS cord-005453-4057qib7 15137 5 responded respond VBD cord-005453-4057qib7 15137 6 to to IN cord-005453-4057qib7 15137 7 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 15137 8 therapy therapy NN cord-005453-4057qib7 15137 9 with with IN cord-005453-4057qib7 15137 10 steroids steroid NNS cord-005453-4057qib7 15137 11 ± ± NNP cord-005453-4057qib7 15137 12 ECP ECP NNP cord-005453-4057qib7 15137 13 and and CC cord-005453-4057qib7 15137 14 re re NN cord-005453-4057qib7 15137 15 - - NN cord-005453-4057qib7 15137 16 initiation initiation NN cord-005453-4057qib7 15137 17 of of IN cord-005453-4057qib7 15137 18 CNI CNI NNP cord-005453-4057qib7 15137 19 ( ( -LRB- cord-005453-4057qib7 15137 20 n=1 n=1 NNP cord-005453-4057qib7 15137 21 ) ) -RRB- cord-005453-4057qib7 15137 22 . . . cord-005453-4057qib7 15138 1 One one CD cord-005453-4057qib7 15138 2 patient patient NN cord-005453-4057qib7 15138 3 suffered suffer VBD cord-005453-4057qib7 15138 4 Background background NN cord-005453-4057qib7 15138 5 : : : cord-005453-4057qib7 15138 6 Patients patient NNS cord-005453-4057qib7 15138 7 with with IN cord-005453-4057qib7 15138 8 relapsed relapsed JJ cord-005453-4057qib7 15138 9 or or CC cord-005453-4057qib7 15138 10 refractory refractory JJ cord-005453-4057qib7 15138 11 acute acute JJ cord-005453-4057qib7 15138 12 myeloid myeloid NN cord-005453-4057qib7 15138 13 leukaemia leukaemia NN cord-005453-4057qib7 15138 14 ( ( -LRB- cord-005453-4057qib7 15138 15 AML AML NNP cord-005453-4057qib7 15138 16 ) ) -RRB- cord-005453-4057qib7 15138 17 have have VBP cord-005453-4057qib7 15138 18 a a DT cord-005453-4057qib7 15138 19 poor poor JJ cord-005453-4057qib7 15138 20 prognosis prognosis NN cord-005453-4057qib7 15138 21 . . . cord-005453-4057qib7 15139 1 Allogeneic allogeneic IN cord-005453-4057qib7 15139 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 15139 3 stem stem NN cord-005453-4057qib7 15139 4 cell cell NN cord-005453-4057qib7 15139 5 transplantation transplantation NN cord-005453-4057qib7 15139 6 is be VBZ cord-005453-4057qib7 15139 7 the the DT cord-005453-4057qib7 15139 8 only only JJ cord-005453-4057qib7 15139 9 curative curative JJ cord-005453-4057qib7 15139 10 option option NN cord-005453-4057qib7 15139 11 . . . cord-005453-4057qib7 15140 1 However however RB cord-005453-4057qib7 15140 2 , , , cord-005453-4057qib7 15140 3 allogeneic allogeneic IN cord-005453-4057qib7 15140 4 transplantation transplantation NN cord-005453-4057qib7 15140 5 with with IN cord-005453-4057qib7 15140 6 active active JJ cord-005453-4057qib7 15140 7 leukemia leukemia NN cord-005453-4057qib7 15140 8 failed fail VBD cord-005453-4057qib7 15140 9 to to TO cord-005453-4057qib7 15140 10 improve improve VB cord-005453-4057qib7 15140 11 significantly significantly RB cord-005453-4057qib7 15140 12 the the DT cord-005453-4057qib7 15140 13 longterm longterm JJ cord-005453-4057qib7 15140 14 outcome outcome NN cord-005453-4057qib7 15140 15 . . . cord-005453-4057qib7 15141 1 To to TO cord-005453-4057qib7 15141 2 improve improve VB cord-005453-4057qib7 15141 3 the the DT cord-005453-4057qib7 15141 4 outcome outcome NN cord-005453-4057qib7 15141 5 of of IN cord-005453-4057qib7 15141 6 allo allo NN cord-005453-4057qib7 15141 7 - - HYPH cord-005453-4057qib7 15141 8 HSCT HSCT NNP cord-005453-4057qib7 15141 9 in in IN cord-005453-4057qib7 15141 10 such such JJ cord-005453-4057qib7 15141 11 high high JJ cord-005453-4057qib7 15141 12 - - HYPH cord-005453-4057qib7 15141 13 risk risk NN cord-005453-4057qib7 15141 14 and and CC cord-005453-4057qib7 15141 15 refractory refractory JJ cord-005453-4057qib7 15141 16 patients patient NNS cord-005453-4057qib7 15141 17 , , , cord-005453-4057qib7 15141 18 sequential sequential JJ cord-005453-4057qib7 15141 19 schedule schedule NN cord-005453-4057qib7 15141 20 of of IN cord-005453-4057qib7 15141 21 cytoreduction cytoreduction NN cord-005453-4057qib7 15141 22 therapy therapy NN cord-005453-4057qib7 15141 23 followed follow VBN cord-005453-4057qib7 15141 24 by by IN cord-005453-4057qib7 15141 25 nonmyeloablative nonmyeloablative JJ cord-005453-4057qib7 15141 26 conditioning conditioning NN cord-005453-4057qib7 15141 27 has have VBZ cord-005453-4057qib7 15141 28 been be VBN cord-005453-4057qib7 15141 29 developed develop VBN cord-005453-4057qib7 15141 30 . . . cord-005453-4057qib7 15142 1 Methods method NNS cord-005453-4057qib7 15142 2 : : : cord-005453-4057qib7 15142 3 To to TO cord-005453-4057qib7 15142 4 evaluate evaluate VB cord-005453-4057qib7 15142 5 the the DT cord-005453-4057qib7 15142 6 outcome outcome NN cord-005453-4057qib7 15142 7 of of IN cord-005453-4057qib7 15142 8 sequential sequential JJ cord-005453-4057qib7 15142 9 intensified intensify VBN cord-005453-4057qib7 15142 10 conditioning conditioning NN cord-005453-4057qib7 15142 11 regimen regimen NN cord-005453-4057qib7 15142 12 followed follow VBN cord-005453-4057qib7 15142 13 by by IN cord-005453-4057qib7 15142 14 allogeneic allogeneic JJ cord-005453-4057qib7 15142 15 hematopoietic hematopoietic JJ cord-005453-4057qib7 15142 16 stem stem NN cord-005453-4057qib7 15142 17 cell cell NN cord-005453-4057qib7 15142 18 transplantation transplantation NN cord-005453-4057qib7 15142 19 ( ( -LRB- cord-005453-4057qib7 15142 20 allo allo NN cord-005453-4057qib7 15142 21 - - HYPH cord-005453-4057qib7 15142 22 HSCT HSCT NNP cord-005453-4057qib7 15142 23 ) ) -RRB- cord-005453-4057qib7 15142 24 for for IN cord-005453-4057qib7 15142 25 refractory refractory JJ cord-005453-4057qib7 15142 26 acute acute JJ cord-005453-4057qib7 15142 27 myeloid myeloid NN cord-005453-4057qib7 15142 28 leukemia leukemia NN cord-005453-4057qib7 15142 29 ( ( -LRB- cord-005453-4057qib7 15142 30 AML AML NNP cord-005453-4057qib7 15142 31 ) ) -RRB- cord-005453-4057qib7 15142 32 . . . cord-005453-4057qib7 15143 1 Results result NNS cord-005453-4057qib7 15143 2 : : : cord-005453-4057qib7 15144 1 A a DT cord-005453-4057qib7 15144 2 total total NN cord-005453-4057qib7 15144 3 of of IN cord-005453-4057qib7 15144 4 20 20 CD cord-005453-4057qib7 15144 5 patients patient NNS cord-005453-4057qib7 15144 6 with with IN cord-005453-4057qib7 15144 7 primary primary JJ cord-005453-4057qib7 15144 8 or or CC cord-005453-4057qib7 15144 9 secondary secondary JJ cord-005453-4057qib7 15144 10 refractory refractory JJ cord-005453-4057qib7 15144 11 AML AML NNP cord-005453-4057qib7 15144 12 transplanted transplant VBN cord-005453-4057qib7 15144 13 between between IN cord-005453-4057qib7 15144 14 June June NNP cord-005453-4057qib7 15144 15 2011 2011 CD cord-005453-4057qib7 15144 16 to to IN cord-005453-4057qib7 15144 17 July July NNP cord-005453-4057qib7 15144 18 2018 2018 CD cord-005453-4057qib7 15144 19 were be VBD cord-005453-4057qib7 15144 20 included include VBN cord-005453-4057qib7 15144 21 . . . cord-005453-4057qib7 15145 1 Refractoriness Refractoriness NNP cord-005453-4057qib7 15145 2 was be VBD cord-005453-4057qib7 15145 3 defined define VBN cord-005453-4057qib7 15145 4 as as IN cord-005453-4057qib7 15145 5 primary primary JJ cord-005453-4057qib7 15145 6 induction induction NN cord-005453-4057qib7 15145 7 failure failure NN cord-005453-4057qib7 15145 8 , , , cord-005453-4057qib7 15145 9 relapse relapse NN cord-005453-4057qib7 15145 10 within within IN cord-005453-4057qib7 15145 11 6 6 CD cord-005453-4057qib7 15145 12 months month NNS cord-005453-4057qib7 15145 13 from from IN cord-005453-4057qib7 15145 14 induction/ induction/ CD cord-005453-4057qib7 15145 15 consolidation consolidation NN cord-005453-4057qib7 15145 16 chemotherapy chemotherapy NN cord-005453-4057qib7 15145 17 or or CC cord-005453-4057qib7 15145 18 second second JJ cord-005453-4057qib7 15145 19 relapse relapse NN cord-005453-4057qib7 15145 20 . . . cord-005453-4057qib7 15146 1 Median median JJ cord-005453-4057qib7 15146 2 age age NN cord-005453-4057qib7 15146 3 is be VBZ cord-005453-4057qib7 15146 4 39 39 CD cord-005453-4057qib7 15146 5 years year NNS cord-005453-4057qib7 15146 6 ( ( -LRB- cord-005453-4057qib7 15146 7 1 1 CD cord-005453-4057qib7 15146 8 to to IN cord-005453-4057qib7 15146 9 61 61 CD cord-005453-4057qib7 15146 10 ) ) -RRB- cord-005453-4057qib7 15146 11 . . . cord-005453-4057qib7 15147 1 The the DT cord-005453-4057qib7 15147 2 salvage salvage NN cord-005453-4057qib7 15147 3 chemotherapy chemotherapy NN cord-005453-4057qib7 15147 4 administered administer VBN cord-005453-4057qib7 15147 5 was be VBD cord-005453-4057qib7 15147 6 FLAG FLAG NNP cord-005453-4057qib7 15147 7 - - HYPH cord-005453-4057qib7 15147 8 IDA IDA NNP cord-005453-4057qib7 15147 9 . . . cord-005453-4057qib7 15148 1 Two two CD cord-005453-4057qib7 15148 2 patients patient NNS cord-005453-4057qib7 15148 3 did do VBD cord-005453-4057qib7 15148 4 not not RB cord-005453-4057qib7 15148 5 receive receive VB cord-005453-4057qib7 15148 6 intensive intensive JJ cord-005453-4057qib7 15148 7 chemotherapy chemotherapy NN cord-005453-4057qib7 15148 8 because because IN cord-005453-4057qib7 15148 9 of of IN cord-005453-4057qib7 15148 10 no no DT cord-005453-4057qib7 15148 11 recovery recovery NN cord-005453-4057qib7 15148 12 after after IN cord-005453-4057qib7 15148 13 induction induction NN cord-005453-4057qib7 15148 14 chemotherapy chemotherapy NN cord-005453-4057qib7 15148 15 . . . cord-005453-4057qib7 15149 1 Seven seven CD cord-005453-4057qib7 15149 2 days day NNS cord-005453-4057qib7 15149 3 after after IN cord-005453-4057qib7 15149 4 the the DT cord-005453-4057qib7 15149 5 end end NN cord-005453-4057qib7 15149 6 of of IN cord-005453-4057qib7 15149 7 FLAG FLAG NNP cord-005453-4057qib7 15149 8 - - HYPH cord-005453-4057qib7 15149 9 IDA IDA NNP cord-005453-4057qib7 15149 10 , , , cord-005453-4057qib7 15149 11 a a DT cord-005453-4057qib7 15149 12 reduced reduce VBN cord-005453-4057qib7 15149 13 intensity intensity NN cord-005453-4057qib7 15149 14 conditioning conditioning NN cord-005453-4057qib7 15149 15 consisting consist VBG cord-005453-4057qib7 15149 16 of of IN cord-005453-4057qib7 15149 17 fludarabine,60 fludarabine,60 NNP cord-005453-4057qib7 15149 18 mg mg NNP cord-005453-4057qib7 15149 19 / / SYM cord-005453-4057qib7 15149 20 m2 m2 NNP cord-005453-4057qib7 15149 21 , , , cord-005453-4057qib7 15149 22 thiotepa thiotepa JJ cord-005453-4057qib7 15149 23 , , , cord-005453-4057qib7 15149 24 5mg 5mg NN cord-005453-4057qib7 15149 25 / / SYM cord-005453-4057qib7 15149 26 kg kg NN cord-005453-4057qib7 15149 27 and and CC cord-005453-4057qib7 15149 28 busulfan busulfan NN cord-005453-4057qib7 15150 1 6,4 6,4 CD cord-005453-4057qib7 15151 1 mg mg NNP cord-005453-4057qib7 15151 2 / / SYM cord-005453-4057qib7 15151 3 kg kg NNP cord-005453-4057qib7 15151 4 i.v i.v NNP cord-005453-4057qib7 15151 5 . . . cord-005453-4057qib7 15152 1 ( ( -LRB- cord-005453-4057qib7 15152 2 n=12 n=12 NNP cord-005453-4057qib7 15152 3 ) ) -RRB- cord-005453-4057qib7 15152 4 for for IN cord-005453-4057qib7 15152 5 haploidentical haploidentical JJ cord-005453-4057qib7 15152 6 donors donor NNS cord-005453-4057qib7 15152 7 or or CC cord-005453-4057qib7 15152 8 fludarabine fludarabine NN cord-005453-4057qib7 15152 9 plus plus CC cord-005453-4057qib7 15152 10 busulfan busulfan NN cord-005453-4057qib7 15152 11 ( ( -LRB- cord-005453-4057qib7 15152 12 n=8 n=8 NN cord-005453-4057qib7 15152 13 ) ) -RRB- cord-005453-4057qib7 15152 14 for for IN cord-005453-4057qib7 15152 15 HLA HLA NNP cord-005453-4057qib7 15152 16 identical identical JJ cord-005453-4057qib7 15152 17 sibling sibling NN cord-005453-4057qib7 15152 18 or or CC cord-005453-4057qib7 15152 19 unrelated unrelated JJ cord-005453-4057qib7 15152 20 donors donor NNS cord-005453-4057qib7 15152 21 was be VBD cord-005453-4057qib7 15152 22 administered administer VBN cord-005453-4057qib7 15152 23 . . . cord-005453-4057qib7 15153 1 Graft graft NN cord-005453-4057qib7 15153 2 - - HYPH cord-005453-4057qib7 15153 3 versus versus IN cord-005453-4057qib7 15153 4 - - HYPH cord-005453-4057qib7 15153 5 host host NN cord-005453-4057qib7 15153 6 disease disease NN cord-005453-4057qib7 15153 7 ( ( -LRB- cord-005453-4057qib7 15153 8 GVHD GVHD NNP cord-005453-4057qib7 15153 9 ) ) -RRB- cord-005453-4057qib7 15153 10 prophylaxis prophylaxis NN cord-005453-4057qib7 15153 11 consisted consist VBD cord-005453-4057qib7 15153 12 of of IN cord-005453-4057qib7 15153 13 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 15153 14 and and CC cord-005453-4057qib7 15153 15 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 15153 16 mofetil mofetil NNP cord-005453-4057qib7 15153 17 . . . cord-005453-4057qib7 15154 1 The the DT cord-005453-4057qib7 15154 2 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 15154 3 was be VBD cord-005453-4057qib7 15154 4 withdrawn withdraw VBN cord-005453-4057qib7 15154 5 at at IN cord-005453-4057qib7 15154 6 day day NN cord-005453-4057qib7 15154 7 +35 +35 CD cord-005453-4057qib7 15154 8 post post NN cord-005453-4057qib7 15154 9 - - NN cord-005453-4057qib7 15154 10 transplantation transplantation NN cord-005453-4057qib7 15154 11 and and CC cord-005453-4057qib7 15154 12 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 15154 13 at at IN cord-005453-4057qib7 15154 14 day day NN cord-005453-4057qib7 15154 15 +100 +100 NNS cord-005453-4057qib7 15154 16 . . . cord-005453-4057qib7 15155 1 Donor donor NN cord-005453-4057qib7 15155 2 lymphocytes lymphocyte NNS cord-005453-4057qib7 15155 3 ( ( -LRB- cord-005453-4057qib7 15155 4 DLI DLI NNP cord-005453-4057qib7 15155 5 ) ) -RRB- cord-005453-4057qib7 15155 6 were be VBD cord-005453-4057qib7 15155 7 infused infuse VBN cord-005453-4057qib7 15155 8 in in IN cord-005453-4057qib7 15155 9 patients patient NNS cord-005453-4057qib7 15155 10 without without IN cord-005453-4057qib7 15155 11 aGVHD aGVHD NNP cord-005453-4057qib7 15155 12 at at IN cord-005453-4057qib7 15155 13 Day day NN cord-005453-4057qib7 15155 14 +120 +120 NNP cord-005453-4057qib7 15155 15 post post NN cord-005453-4057qib7 15155 16 - - NN cord-005453-4057qib7 15155 17 transplantation transplantation NN cord-005453-4057qib7 15155 18 . . . cord-005453-4057qib7 15156 1 Seventeen seventeen CD cord-005453-4057qib7 15156 2 patients patient NNS cord-005453-4057qib7 15156 3 achieved achieve VBD cord-005453-4057qib7 15156 4 complete complete JJ cord-005453-4057qib7 15156 5 donor donor NN cord-005453-4057qib7 15156 6 chimerism chimerism NN cord-005453-4057qib7 15156 7 , , , cord-005453-4057qib7 15156 8 3 3 CD cord-005453-4057qib7 15156 9 patients patient NNS cord-005453-4057qib7 15156 10 progressed progress VBD cord-005453-4057qib7 15156 11 early early JJ cord-005453-4057qib7 15156 12 and and CC cord-005453-4057qib7 15156 13 1 1 CD cord-005453-4057qib7 15156 14 patient patient NN cord-005453-4057qib7 15156 15 died die VBD cord-005453-4057qib7 15156 16 before before IN cord-005453-4057qib7 15156 17 engraftment engraftment NN cord-005453-4057qib7 15156 18 . . . cord-005453-4057qib7 15157 1 One one CD cord-005453-4057qib7 15157 2 of of IN cord-005453-4057qib7 15157 3 the the DT cord-005453-4057qib7 15157 4 patients patient NNS cord-005453-4057qib7 15157 5 which which WDT cord-005453-4057qib7 15157 6 recovery recovery NN cord-005453-4057qib7 15157 7 was be VBD cord-005453-4057qib7 15157 8 with with IN cord-005453-4057qib7 15157 9 persistent persistent JJ cord-005453-4057qib7 15157 10 leukemia leukemia NN cord-005453-4057qib7 15157 11 reached reach VBD cord-005453-4057qib7 15157 12 donor donor NN cord-005453-4057qib7 15157 13 chimerism chimerism NN cord-005453-4057qib7 15157 14 after after IN cord-005453-4057qib7 15157 15 immunosupression immunosupression NN cord-005453-4057qib7 15157 16 discontinuation discontinuation NN cord-005453-4057qib7 15157 17 . . . cord-005453-4057qib7 15158 1 Ten ten CD cord-005453-4057qib7 15158 2 patients patient NNS cord-005453-4057qib7 15158 3 are be VBP cord-005453-4057qib7 15158 4 alive alive JJ cord-005453-4057qib7 15158 5 in in IN cord-005453-4057qib7 15158 6 complete complete JJ cord-005453-4057qib7 15158 7 remission remission NN cord-005453-4057qib7 15158 8 . . . cord-005453-4057qib7 15159 1 Median median JJ cord-005453-4057qib7 15159 2 follow follow NN cord-005453-4057qib7 15159 3 - - HYPH cord-005453-4057qib7 15159 4 up up NN cord-005453-4057qib7 15159 5 of of IN cord-005453-4057qib7 15159 6 survivors survivor NNS cord-005453-4057qib7 15159 7 is be VBZ cord-005453-4057qib7 15159 8 28 28 CD cord-005453-4057qib7 15159 9 months month NNS cord-005453-4057qib7 15160 1 ( ( -LRB- cord-005453-4057qib7 15160 2 range range NN cord-005453-4057qib7 15160 3 : : : cord-005453-4057qib7 15160 4 6 6 CD cord-005453-4057qib7 15160 5 - - SYM cord-005453-4057qib7 15160 6 43 43 CD cord-005453-4057qib7 15160 7 ) ) -RRB- cord-005453-4057qib7 15160 8 . . . cord-005453-4057qib7 15161 1 Five five CD cord-005453-4057qib7 15161 2 patients patient NNS cord-005453-4057qib7 15161 3 died die VBD cord-005453-4057qib7 15161 4 of of IN cord-005453-4057qib7 15161 5 leukemic leukemic JJ cord-005453-4057qib7 15161 6 progression progression NN cord-005453-4057qib7 15161 7 , , , cord-005453-4057qib7 15161 8 3 3 CD cord-005453-4057qib7 15161 9 as as IN cord-005453-4057qib7 15161 10 result result NN cord-005453-4057qib7 15161 11 of of IN cord-005453-4057qib7 15161 12 GVHD GVHD NNP cord-005453-4057qib7 15161 13 and and CC cord-005453-4057qib7 15161 14 1 1 CD cord-005453-4057qib7 15161 15 suffered suffer VBD cord-005453-4057qib7 15161 16 intracranial intracranial JJ cord-005453-4057qib7 15161 17 hemorrhage hemorrhage NN cord-005453-4057qib7 15161 18 . . . cord-005453-4057qib7 15162 1 Five five CD cord-005453-4057qib7 15162 2 patients patient NNS cord-005453-4057qib7 15162 3 received receive VBD cord-005453-4057qib7 15162 4 prophylactic prophylactic JJ cord-005453-4057qib7 15162 5 DLI DLI NNP cord-005453-4057qib7 15162 6 . . . cord-005453-4057qib7 15163 1 The the DT cord-005453-4057qib7 15163 2 incidence incidence NN cord-005453-4057qib7 15163 3 of of IN cord-005453-4057qib7 15163 4 acute acute JJ cord-005453-4057qib7 15163 5 moderate moderate JJ cord-005453-4057qib7 15163 6 - - HYPH cord-005453-4057qib7 15163 7 severe severe JJ cord-005453-4057qib7 15163 8 GVHD GVHD NNP cord-005453-4057qib7 15163 9 and and CC cord-005453-4057qib7 15163 10 moderate moderate JJ cord-005453-4057qib7 15163 11 - - HYPH cord-005453-4057qib7 15163 12 severe severe JJ cord-005453-4057qib7 15163 13 chronic chronic JJ cord-005453-4057qib7 15163 14 GVHD GVHD NNP cord-005453-4057qib7 15163 15 were be VBD cord-005453-4057qib7 15163 16 70 70 CD cord-005453-4057qib7 15163 17 % % NN cord-005453-4057qib7 15163 18 ( ( -LRB- cord-005453-4057qib7 15163 19 n=14 n=14 NNP cord-005453-4057qib7 15163 20 ) ) -RRB- cord-005453-4057qib7 15163 21 and and CC cord-005453-4057qib7 15163 22 50 50 CD cord-005453-4057qib7 15163 23 % % NN cord-005453-4057qib7 15163 24 ( ( -LRB- cord-005453-4057qib7 15163 25 n=7 n=7 NNS cord-005453-4057qib7 15163 26 ) ) -RRB- cord-005453-4057qib7 15163 27 , , , cord-005453-4057qib7 15163 28 respectively respectively RB cord-005453-4057qib7 15163 29 . . . cord-005453-4057qib7 15164 1 The the DT cord-005453-4057qib7 15164 2 non non JJ cord-005453-4057qib7 15164 3 - - JJ cord-005453-4057qib7 15164 4 relapse relapse JJ cord-005453-4057qib7 15164 5 mortality mortality NN cord-005453-4057qib7 15164 6 was be VBD cord-005453-4057qib7 15164 7 21 21 CD cord-005453-4057qib7 15164 8 % % NN cord-005453-4057qib7 15164 9 ( ( -LRB- cord-005453-4057qib7 15164 10 n=4 n=4 NNP cord-005453-4057qib7 15164 11 ) ) -RRB- cord-005453-4057qib7 15164 12 , , , cord-005453-4057qib7 15164 13 mainly mainly RB cord-005453-4057qib7 15164 14 due due JJ cord-005453-4057qib7 15164 15 to to IN cord-005453-4057qib7 15164 16 acute acute JJ cord-005453-4057qib7 15164 17 GVHD GVHD NNP cord-005453-4057qib7 15164 18 ( ( -LRB- cord-005453-4057qib7 15164 19 n=3 n=3 NN cord-005453-4057qib7 15164 20 ) ) -RRB- cord-005453-4057qib7 15164 21 . . . cord-005453-4057qib7 15165 1 The the DT cord-005453-4057qib7 15165 2 2-year 2-year CD cord-005453-4057qib7 15165 3 cumulative cumulative JJ cord-005453-4057qib7 15165 4 incidence incidence NN cord-005453-4057qib7 15165 5 of of IN cord-005453-4057qib7 15165 6 relapse relapse NN cord-005453-4057qib7 15165 7 posttransplantation posttransplantation NNP cord-005453-4057qib7 15165 8 was be VBD cord-005453-4057qib7 15165 9 36.8 36.8 CD cord-005453-4057qib7 15165 10 % % NN cord-005453-4057qib7 15165 11 . . . cord-005453-4057qib7 15166 1 The the DT cord-005453-4057qib7 15166 2 probability probability NN cord-005453-4057qib7 15166 3 of of IN cord-005453-4057qib7 15166 4 relapse relapse NN cord-005453-4057qib7 15166 5 was be VBD cord-005453-4057qib7 15166 6 57%±13 57%±13 CD cord-005453-4057qib7 15166 7 % % NN cord-005453-4057qib7 15166 8 . . . cord-005453-4057qib7 15167 1 The the DT cord-005453-4057qib7 15167 2 2-year 2-year CD cord-005453-4057qib7 15167 3 OS OS NNP cord-005453-4057qib7 15167 4 and and CC cord-005453-4057qib7 15167 5 DFS DFS NNP cord-005453-4057qib7 15167 6 were be VBD cord-005453-4057qib7 15167 7 46 46 CD cord-005453-4057qib7 15167 8 % % NN cord-005453-4057qib7 15167 9 ± ± CD cord-005453-4057qib7 15167 10 12 12 CD cord-005453-4057qib7 15167 11 % % NN cord-005453-4057qib7 15167 12 and and CC cord-005453-4057qib7 15167 13 38 38 CD cord-005453-4057qib7 15167 14 % % NN cord-005453-4057qib7 15167 15 ± ± CD cord-005453-4057qib7 15167 16 12 12 CD cord-005453-4057qib7 15167 17 % % NN cord-005453-4057qib7 15167 18 Conclusions conclusion NNS cord-005453-4057qib7 15167 19 : : : cord-005453-4057qib7 15168 1 The the DT cord-005453-4057qib7 15168 2 strategy strategy NN cord-005453-4057qib7 15168 3 of of IN cord-005453-4057qib7 15168 4 sequential sequential JJ cord-005453-4057qib7 15168 5 chemotherapy chemotherapy NN cord-005453-4057qib7 15168 6 followed follow VBN cord-005453-4057qib7 15168 7 by by IN cord-005453-4057qib7 15168 8 alloHSCT alloHSCT NNP cord-005453-4057qib7 15168 9 ± ± NNP cord-005453-4057qib7 15168 10 prophylactic prophylactic JJ cord-005453-4057qib7 15168 11 DLI DLI NNP cord-005453-4057qib7 15168 12 has have VBZ cord-005453-4057qib7 15168 13 an an DT cord-005453-4057qib7 15168 14 acceptable acceptable JJ cord-005453-4057qib7 15168 15 toxicity toxicity NN cord-005453-4057qib7 15168 16 profile profile NN cord-005453-4057qib7 15168 17 and and CC cord-005453-4057qib7 15168 18 improves improve VBZ cord-005453-4057qib7 15168 19 both both PDT cord-005453-4057qib7 15168 20 the the DT cord-005453-4057qib7 15168 21 relapse relapse NN cord-005453-4057qib7 15168 22 rate rate NN cord-005453-4057qib7 15168 23 and and CC cord-005453-4057qib7 15168 24 the the DT cord-005453-4057qib7 15168 25 survival survival NN cord-005453-4057qib7 15168 26 for for IN cord-005453-4057qib7 15168 27 refractory refractory JJ cord-005453-4057qib7 15168 28 AML AML NNP cord-005453-4057qib7 15168 29 patients patient NNS cord-005453-4057qib7 15168 30 . . . cord-005453-4057qib7 15169 1 Disclosure disclosure NN cord-005453-4057qib7 15169 2 : : : cord-005453-4057qib7 15169 3 Nothing nothing NN cord-005453-4057qib7 15169 4 to to TO cord-005453-4057qib7 15169 5 declare declare VB cord-005453-4057qib7 15169 6 Background background NN cord-005453-4057qib7 15169 7 : : : cord-005453-4057qib7 15170 1 The the DT cord-005453-4057qib7 15170 2 concept concept NN cord-005453-4057qib7 15170 3 of of IN cord-005453-4057qib7 15170 4 immunological immunological JJ cord-005453-4057qib7 15170 5 intervention intervention NN cord-005453-4057qib7 15170 6 to to TO cord-005453-4057qib7 15170 7 prevent prevent VB cord-005453-4057qib7 15170 8 relapse relapse NN cord-005453-4057qib7 15170 9 after after IN cord-005453-4057qib7 15170 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 15170 11 stem stem NN cord-005453-4057qib7 15170 12 cell cell NN cord-005453-4057qib7 15170 13 transplantation transplantation NN cord-005453-4057qib7 15170 14 is be VBZ cord-005453-4057qib7 15170 15 associated associate VBN cord-005453-4057qib7 15170 16 with with IN cord-005453-4057qib7 15170 17 the the DT cord-005453-4057qib7 15170 18 assessment assessment NN cord-005453-4057qib7 15170 19 of of IN cord-005453-4057qib7 15170 20 the the DT cord-005453-4057qib7 15170 21 chimerism chimerism NN cord-005453-4057qib7 15170 22 status status NN cord-005453-4057qib7 15170 23 . . . cord-005453-4057qib7 15171 1 Distinguishing distinguish VBG cord-005453-4057qib7 15172 1 patient patient JJ cord-005453-4057qib7 15172 2 and and CC cord-005453-4057qib7 15172 3 donor donor NN cord-005453-4057qib7 15172 4 hematopoiesis hematopoiesis NN cord-005453-4057qib7 15172 5 is be VBZ cord-005453-4057qib7 15172 6 usually usually RB cord-005453-4057qib7 15172 7 performed perform VBN cord-005453-4057qib7 15172 8 by by IN cord-005453-4057qib7 15172 9 STR STR NNP cord-005453-4057qib7 15172 10 - - HYPH cord-005453-4057qib7 15172 11 PCR PCR NNP cord-005453-4057qib7 15172 12 , , , cord-005453-4057qib7 15172 13 a a DT cord-005453-4057qib7 15172 14 powerful powerful JJ cord-005453-4057qib7 15172 15 method method NN cord-005453-4057qib7 15172 16 developed develop VBN cord-005453-4057qib7 15172 17 for for IN cord-005453-4057qib7 15172 18 forensic forensic JJ cord-005453-4057qib7 15172 19 purposes purpose NNS cord-005453-4057qib7 15172 20 . . . cord-005453-4057qib7 15173 1 However however RB cord-005453-4057qib7 15173 2 , , , cord-005453-4057qib7 15173 3 this this DT cord-005453-4057qib7 15173 4 method method NN cord-005453-4057qib7 15173 5 shows show VBZ cord-005453-4057qib7 15173 6 restrictions restriction NNS cord-005453-4057qib7 15173 7 with with IN cord-005453-4057qib7 15173 8 respect respect NN cord-005453-4057qib7 15173 9 to to IN cord-005453-4057qib7 15173 10 detection detection NN cord-005453-4057qib7 15173 11 limit limit NN cord-005453-4057qib7 15173 12 , , , cord-005453-4057qib7 15173 13 preciseness preciseness NN cord-005453-4057qib7 15173 14 , , , cord-005453-4057qib7 15173 15 and and CC cord-005453-4057qib7 15173 16 the the DT cord-005453-4057qib7 15173 17 possibility possibility NN cord-005453-4057qib7 15173 18 of of IN cord-005453-4057qib7 15173 19 automated automated JJ cord-005453-4057qib7 15173 20 read read VBN cord-005453-4057qib7 15173 21 out out RP cord-005453-4057qib7 15173 22 . . . cord-005453-4057qib7 15174 1 Digital Digital NNP cord-005453-4057qib7 15174 2 PCR PCR NNP cord-005453-4057qib7 15174 3 could could MD cord-005453-4057qib7 15174 4 circumvent circumvent VB cord-005453-4057qib7 15174 5 some some DT cord-005453-4057qib7 15174 6 of of IN cord-005453-4057qib7 15174 7 these these DT cord-005453-4057qib7 15174 8 limitations limitation NNS cord-005453-4057qib7 15174 9 . . . cord-005453-4057qib7 15175 1 Methods method NNS cord-005453-4057qib7 15175 2 : : : cord-005453-4057qib7 15175 3 Recently recently RB cord-005453-4057qib7 15175 4 , , , cord-005453-4057qib7 15175 5 validated validate VBN cord-005453-4057qib7 15175 6 for for IN cord-005453-4057qib7 15175 7 the the DT cord-005453-4057qib7 15175 8 Bio Bio NNP cord-005453-4057qib7 15175 9 - - HYPH cord-005453-4057qib7 15175 10 Rad Rad NNP cord-005453-4057qib7 15175 11 droplet droplet NN cord-005453-4057qib7 15175 12 digital digital JJ cord-005453-4057qib7 15175 13 platforms platform NNS cord-005453-4057qib7 15175 14 , , , cord-005453-4057qib7 15175 15 the the DT cord-005453-4057qib7 15175 16 Biotype Biotype NNP cord-005453-4057qib7 15175 17 Mentype Mentype NNP cord-005453-4057qib7 15175 18 DigitalQuant DigitalQuant NNP cord-005453-4057qib7 15175 19 Assay Assay NNP cord-005453-4057qib7 15175 20 was be VBD cord-005453-4057qib7 15175 21 released release VBN cord-005453-4057qib7 15175 22 . . . cord-005453-4057qib7 15176 1 The the DT cord-005453-4057qib7 15176 2 assay assay NN cord-005453-4057qib7 15176 3 uses use VBZ cord-005453-4057qib7 15176 4 INDEL INDEL NNP cord-005453-4057qib7 15176 5 polymorphisms polymorphism NNS cord-005453-4057qib7 15176 6 on on IN cord-005453-4057qib7 15176 7 chromosomal chromosomal JJ cord-005453-4057qib7 15176 8 DNA dna NN cord-005453-4057qib7 15176 9 to to TO cord-005453-4057qib7 15176 10 distinguish distinguish VB cord-005453-4057qib7 15176 11 patient patient NN cord-005453-4057qib7 15176 12 and and CC cord-005453-4057qib7 15176 13 donor donor NN cord-005453-4057qib7 15176 14 hematopoiesis hematopoiesis NN cord-005453-4057qib7 15176 15 on on IN cord-005453-4057qib7 15176 16 a a DT cord-005453-4057qib7 15176 17 FRET fret NN cord-005453-4057qib7 15176 18 hydrolysis hydrolysis NN cord-005453-4057qib7 15176 19 assay assay NN cord-005453-4057qib7 15176 20 basis basis NN cord-005453-4057qib7 15176 21 ( ( -LRB- cord-005453-4057qib7 15176 22 " " `` cord-005453-4057qib7 15176 23 TaqMan TaqMan NNP cord-005453-4057qib7 15176 24 assays assay NNS cord-005453-4057qib7 15176 25 " " '' cord-005453-4057qib7 15176 26 ) ) -RRB- cord-005453-4057qib7 15176 27 . . . cord-005453-4057qib7 15177 1 Thus thus RB cord-005453-4057qib7 15177 2 the the DT cord-005453-4057qib7 15177 3 assay assay NN cord-005453-4057qib7 15177 4 in in IN cord-005453-4057qib7 15177 5 principle principle NN cord-005453-4057qib7 15177 6 is be VBZ cord-005453-4057qib7 15177 7 applicable applicable JJ cord-005453-4057qib7 15177 8 on on IN cord-005453-4057qib7 15177 9 the the DT cord-005453-4057qib7 15177 10 chamber chamber NN cord-005453-4057qib7 15177 11 based base VBN cord-005453-4057qib7 15177 12 3 3 CD cord-005453-4057qib7 15177 13 D D NNP cord-005453-4057qib7 15177 14 digital digital JJ cord-005453-4057qib7 15177 15 PCR pcr NN cord-005453-4057qib7 15177 16 system system NN cord-005453-4057qib7 15177 17 ( ( -LRB- cord-005453-4057qib7 15177 18 Thermo Thermo NNP cord-005453-4057qib7 15177 19 Fisher Fisher NNP cord-005453-4057qib7 15177 20 ) ) -RRB- cord-005453-4057qib7 15177 21 . . . cord-005453-4057qib7 15178 1 Due due IN cord-005453-4057qib7 15178 2 to to IN cord-005453-4057qib7 15178 3 different different JJ cord-005453-4057qib7 15178 4 reaction reaction NN cord-005453-4057qib7 15178 5 chemistry chemistry NN cord-005453-4057qib7 15178 6 and and CC cord-005453-4057qib7 15178 7 physical physical JJ cord-005453-4057qib7 15178 8 properties property NNS cord-005453-4057qib7 15178 9 of of IN cord-005453-4057qib7 15178 10 thermal thermal JJ cord-005453-4057qib7 15178 11 transfer transfer NN cord-005453-4057qib7 15178 12 between between IN cord-005453-4057qib7 15178 13 the the DT cord-005453-4057qib7 15178 14 digital digital JJ cord-005453-4057qib7 15178 15 PCR PCR NNP cord-005453-4057qib7 15178 16 platforms platform NNS cord-005453-4057qib7 15178 17 protocols protocol NNS cord-005453-4057qib7 15178 18 are be VBP cord-005453-4057qib7 15178 19 reasonably reasonably RB cord-005453-4057qib7 15178 20 not not RB cord-005453-4057qib7 15178 21 fully fully RB cord-005453-4057qib7 15178 22 compatible compatible JJ cord-005453-4057qib7 15178 23 which which WDT cord-005453-4057qib7 15178 24 would would MD cord-005453-4057qib7 15178 25 lead lead VB cord-005453-4057qib7 15178 26 to to TO cord-005453-4057qib7 15178 27 lower lower VB cord-005453-4057qib7 15178 28 fluorescence fluorescence NN cord-005453-4057qib7 15178 29 intensities intensity NNS cord-005453-4057qib7 15178 30 and and CC cord-005453-4057qib7 15178 31 poor poor JJ cord-005453-4057qib7 15178 32 signal signal NN cord-005453-4057qib7 15178 33 resolution resolution NN cord-005453-4057qib7 15178 34 on on IN cord-005453-4057qib7 15178 35 the the DT cord-005453-4057qib7 15178 36 solid solid JJ cord-005453-4057qib7 15178 37 chip chip NN cord-005453-4057qib7 15178 38 based base VBN cord-005453-4057qib7 15178 39 Thermo Thermo NNP cord-005453-4057qib7 15178 40 Fisher Fisher NNP cord-005453-4057qib7 15178 41 3D 3d JJ cord-005453-4057qib7 15178 42 platform platform NN cord-005453-4057qib7 15178 43 . . . cord-005453-4057qib7 15179 1 An an DT cord-005453-4057qib7 15179 2 adjusted adjust VBN cord-005453-4057qib7 15179 3 PCR PCR NNP cord-005453-4057qib7 15179 4 protocol protocol NN cord-005453-4057qib7 15179 5 was be VBD cord-005453-4057qib7 15179 6 established establish VBN cord-005453-4057qib7 15179 7 and and CC cord-005453-4057qib7 15179 8 optimized optimize VBN cord-005453-4057qib7 15179 9 using use VBG cord-005453-4057qib7 15179 10 representative representative JJ cord-005453-4057qib7 15179 11 markers marker NNS cord-005453-4057qib7 15179 12 , , , cord-005453-4057qib7 15179 13 followed follow VBN cord-005453-4057qib7 15179 14 by by IN cord-005453-4057qib7 15179 15 determination determination NN cord-005453-4057qib7 15179 16 of of IN cord-005453-4057qib7 15179 17 tolerable tolerable JJ cord-005453-4057qib7 15179 18 and and CC cord-005453-4057qib7 15179 19 optimal optimal JJ cord-005453-4057qib7 15179 20 amount amount NN cord-005453-4057qib7 15179 21 of of IN cord-005453-4057qib7 15179 22 input input NN cord-005453-4057qib7 15179 23 DNA dna NN cord-005453-4057qib7 15179 24 . . . cord-005453-4057qib7 15180 1 Specificity specificity NN cord-005453-4057qib7 15180 2 , , , cord-005453-4057qib7 15180 3 sensitivity sensitivity NN cord-005453-4057qib7 15180 4 and and CC cord-005453-4057qib7 15180 5 reproducibility reproducibility NN cord-005453-4057qib7 15180 6 testing testing NN cord-005453-4057qib7 15180 7 with with IN cord-005453-4057qib7 15180 8 artificial artificial JJ cord-005453-4057qib7 15180 9 mixed mixed JJ cord-005453-4057qib7 15180 10 samples sample NNS cord-005453-4057qib7 15180 11 preceded precede VBD cord-005453-4057qib7 15180 12 the the DT cord-005453-4057qib7 15180 13 extensive extensive JJ cord-005453-4057qib7 15180 14 verification verification NN cord-005453-4057qib7 15180 15 by by IN cord-005453-4057qib7 15180 16 comparative comparative JJ cord-005453-4057qib7 15180 17 measurement measurement NN cord-005453-4057qib7 15180 18 of of IN cord-005453-4057qib7 15180 19 clinical clinical JJ cord-005453-4057qib7 15180 20 samples sample NNS cord-005453-4057qib7 15180 21 ( ( -LRB- cord-005453-4057qib7 15180 22 N=59 N=59 NNP cord-005453-4057qib7 15180 23 ) ) -RRB- cord-005453-4057qib7 15180 24 and and CC cord-005453-4057qib7 15180 25 ring ring NN cord-005453-4057qib7 15180 26 - - HYPH cord-005453-4057qib7 15180 27 trial trial NN cord-005453-4057qib7 15180 28 samples sample NNS cord-005453-4057qib7 15180 29 ( ( -LRB- cord-005453-4057qib7 15180 30 N=20 N=20 NNP cord-005453-4057qib7 15180 31 ) ) -RRB- cord-005453-4057qib7 15180 32 . . . cord-005453-4057qib7 15181 1 source source NN cord-005453-4057qib7 15181 2 to to IN cord-005453-4057qib7 15181 3 allogenic allogenic JJ cord-005453-4057qib7 15181 4 BM BM NNP cord-005453-4057qib7 15181 5 or or CC cord-005453-4057qib7 15181 6 PBSC PBSC NNP cord-005453-4057qib7 15181 7 . . . cord-005453-4057qib7 15182 1 UCB UCB NNP cord-005453-4057qib7 15182 2 units unit NNS cord-005453-4057qib7 15182 3 are be VBP cord-005453-4057qib7 15182 4 immediately immediately RB cord-005453-4057qib7 15182 5 available available JJ cord-005453-4057qib7 15182 6 for for IN cord-005453-4057qib7 15182 7 transplantation transplantation NN cord-005453-4057qib7 15182 8 as as IN cord-005453-4057qib7 15182 9 they -PRON- PRP cord-005453-4057qib7 15182 10 are be VBP cord-005453-4057qib7 15182 11 frozen frozen JJ cord-005453-4057qib7 15182 12 and and CC cord-005453-4057qib7 15182 13 banked bank VBN cord-005453-4057qib7 15182 14 with with IN cord-005453-4057qib7 15182 15 defined define VBN cord-005453-4057qib7 15182 16 HLA HLA NNP cord-005453-4057qib7 15182 17 typing typing NN cord-005453-4057qib7 15182 18 and and CC cord-005453-4057qib7 15182 19 it -PRON- PRP cord-005453-4057qib7 15182 20 has have VBZ cord-005453-4057qib7 15182 21 an an DT cord-005453-4057qib7 15182 22 advantage advantage NN cord-005453-4057qib7 15182 23 for for IN cord-005453-4057qib7 15182 24 patients patient NNS cord-005453-4057qib7 15182 25 who who WP cord-005453-4057qib7 15182 26 need need VBP cord-005453-4057qib7 15182 27 urgent urgent JJ cord-005453-4057qib7 15182 28 transplantation transplantation NN cord-005453-4057qib7 15182 29 . . . cord-005453-4057qib7 15183 1 In in IN cord-005453-4057qib7 15183 2 addition addition NN cord-005453-4057qib7 15183 3 , , , cord-005453-4057qib7 15183 4 a a DT cord-005453-4057qib7 15183 5 higher high JJR cord-005453-4057qib7 15183 6 degree degree NN cord-005453-4057qib7 15183 7 of of IN cord-005453-4057qib7 15183 8 HLA HLA NNP cord-005453-4057qib7 15183 9 mismatch mismatch NN cord-005453-4057qib7 15183 10 appears appear VBZ cord-005453-4057qib7 15183 11 to to TO cord-005453-4057qib7 15183 12 be be VB cord-005453-4057qib7 15183 13 acceptable acceptable JJ cord-005453-4057qib7 15183 14 with with IN cord-005453-4057qib7 15183 15 a a DT cord-005453-4057qib7 15183 16 comparatively comparatively RB cord-005453-4057qib7 15183 17 lower low JJR cord-005453-4057qib7 15183 18 risk risk NN cord-005453-4057qib7 15183 19 of of IN cord-005453-4057qib7 15183 20 acute acute JJ cord-005453-4057qib7 15183 21 and and CC cord-005453-4057qib7 15183 22 chronic chronic JJ cord-005453-4057qib7 15183 23 GVHD GVHD NNP cord-005453-4057qib7 15183 24 . . . cord-005453-4057qib7 15184 1 Meanwhile meanwhile RB cord-005453-4057qib7 15184 2 , , , cord-005453-4057qib7 15184 3 a a DT cord-005453-4057qib7 15184 4 higher high JJR cord-005453-4057qib7 15184 5 incidence incidence NN cord-005453-4057qib7 15184 6 of of IN cord-005453-4057qib7 15184 7 engraftment engraftment NN cord-005453-4057qib7 15184 8 failure failure NN cord-005453-4057qib7 15184 9 , , , cord-005453-4057qib7 15184 10 delayed delay VBN cord-005453-4057qib7 15184 11 neutrophil neutrophil NN cord-005453-4057qib7 15184 12 and and CC cord-005453-4057qib7 15184 13 platelet platelet NN cord-005453-4057qib7 15184 14 recovery recovery NN cord-005453-4057qib7 15184 15 , , , cord-005453-4057qib7 15184 16 and and CC cord-005453-4057qib7 15184 17 posttransplant posttransplant NN cord-005453-4057qib7 15184 18 immune immune JJ cord-005453-4057qib7 15184 19 disorders disorder NNS cord-005453-4057qib7 15184 20 including include VBG cord-005453-4057qib7 15184 21 pre pre JJ cord-005453-4057qib7 15184 22 - - JJ cord-005453-4057qib7 15184 23 engraftment engraftment JJ cord-005453-4057qib7 15184 24 immune immune JJ cord-005453-4057qib7 15184 25 reactions reaction NNS cord-005453-4057qib7 15184 26 ( ( -LRB- cord-005453-4057qib7 15184 27 PIR PIR NNP cord-005453-4057qib7 15184 28 ) ) -RRB- cord-005453-4057qib7 15184 29 are be VBP cord-005453-4057qib7 15184 30 major major JJ cord-005453-4057qib7 15184 31 problems problem NNS cord-005453-4057qib7 15184 32 in in IN cord-005453-4057qib7 15184 33 unrelated unrelated JJ cord-005453-4057qib7 15184 34 UCBT UCBT NNS cord-005453-4057qib7 15184 35 . . . cord-005453-4057qib7 15185 1 Methods method NNS cord-005453-4057qib7 15185 2 : : : cord-005453-4057qib7 15185 3 In in IN cord-005453-4057qib7 15185 4 our -PRON- PRP$ cord-005453-4057qib7 15185 5 institute institute NN cord-005453-4057qib7 15185 6 , , , cord-005453-4057qib7 15185 7 GVHD GVHD NNP cord-005453-4057qib7 15185 8 prophylaxis prophylaxis NN cord-005453-4057qib7 15185 9 in in IN cord-005453-4057qib7 15185 10 UCBT UCBT NNP cord-005453-4057qib7 15185 11 was be VBD cord-005453-4057qib7 15185 12 changed change VBN cord-005453-4057qib7 15185 13 after after IN cord-005453-4057qib7 15185 14 March March NNP cord-005453-4057qib7 15185 15 2013 2013 CD cord-005453-4057qib7 15185 16 . . . cord-005453-4057qib7 15186 1 Between between IN cord-005453-4057qib7 15186 2 January January NNP cord-005453-4057qib7 15186 3 2007 2007 CD cord-005453-4057qib7 15186 4 and and CC cord-005453-4057qib7 15186 5 March March NNP cord-005453-4057qib7 15186 6 2013 2013 CD cord-005453-4057qib7 15186 7 , , , cord-005453-4057qib7 15186 8 thirty thirty CD cord-005453-4057qib7 15186 9 - - HYPH cord-005453-4057qib7 15186 10 two two CD cord-005453-4057qib7 15186 11 patients patient NNS cord-005453-4057qib7 15186 12 received receive VBD cord-005453-4057qib7 15186 13 tacrolimus tacrolimus NNP cord-005453-4057qib7 15186 14 plus plus CC cord-005453-4057qib7 15186 15 methylprednisolone methylprednisolone NNP cord-005453-4057qib7 15186 16 ( ( -LRB- cord-005453-4057qib7 15186 17 Tac Tac NNP cord-005453-4057qib7 15186 18 / / SYM cord-005453-4057qib7 15186 19 mPSL mpsl NN cord-005453-4057qib7 15186 20 ) ) -RRB- cord-005453-4057qib7 15186 21 and and CC cord-005453-4057qib7 15186 22 between between IN cord-005453-4057qib7 15186 23 April April NNP cord-005453-4057qib7 15186 24 2013 2013 CD cord-005453-4057qib7 15186 25 and and CC cord-005453-4057qib7 15186 26 January January NNP cord-005453-4057qib7 15186 27 2018 2018 CD cord-005453-4057qib7 15186 28 , , , cord-005453-4057qib7 15186 29 thirty thirty CD cord-005453-4057qib7 15186 30 - - HYPH cord-005453-4057qib7 15186 31 one one CD cord-005453-4057qib7 15186 32 patients patient NNS cord-005453-4057qib7 15186 33 received receive VBD cord-005453-4057qib7 15186 34 Tac Tac NNP cord-005453-4057qib7 15186 35 plus plus CC cord-005453-4057qib7 15186 36 methotrexate methotrexate NNP cord-005453-4057qib7 15186 37 ( ( -LRB- cord-005453-4057qib7 15186 38 Tac Tac NNP cord-005453-4057qib7 15186 39 / / SYM cord-005453-4057qib7 15186 40 MTX MTX NNP cord-005453-4057qib7 15186 41 ) ) -RRB- cord-005453-4057qib7 15186 42 for for IN cord-005453-4057qib7 15186 43 GVHD GVHD NNP cord-005453-4057qib7 15186 44 prophylaxis prophylaxis NN cord-005453-4057qib7 15186 45 . . . cord-005453-4057qib7 15187 1 To to TO cord-005453-4057qib7 15187 2 investigate investigate VB cord-005453-4057qib7 15187 3 better better RB cord-005453-4057qib7 15187 4 GVHD gvhd JJ cord-005453-4057qib7 15187 5 prophylaxis prophylaxis NN cord-005453-4057qib7 15187 6 after after IN cord-005453-4057qib7 15187 7 UCBT UCBT NNP cord-005453-4057qib7 15187 8 , , , cord-005453-4057qib7 15187 9 we -PRON- PRP cord-005453-4057qib7 15187 10 compared compare VBD cord-005453-4057qib7 15187 11 transplant transplant NN cord-005453-4057qib7 15187 12 outcomes outcome NNS cord-005453-4057qib7 15187 13 after after IN cord-005453-4057qib7 15187 14 UCBT UCBT NNP cord-005453-4057qib7 15187 15 using use VBG cord-005453-4057qib7 15187 16 GVHD GVHD NNP cord-005453-4057qib7 15187 17 prophylaxis prophylaxis NN cord-005453-4057qib7 15187 18 with with IN cord-005453-4057qib7 15187 19 Tac Tac NNP cord-005453-4057qib7 15187 20 / / SYM cord-005453-4057qib7 15187 21 mPSL mPSL NNP cord-005453-4057qib7 15187 22 ( ( -LRB- cord-005453-4057qib7 15187 23 n=32 n=32 NNP cord-005453-4057qib7 15187 24 ) ) -RRB- cord-005453-4057qib7 15187 25 and and CC cord-005453-4057qib7 15187 26 Tac Tac NNP cord-005453-4057qib7 15187 27 / / SYM cord-005453-4057qib7 15187 28 MTX MTX NNP cord-005453-4057qib7 15187 29 ( ( -LRB- cord-005453-4057qib7 15187 30 n=31 n=31 NNP cord-005453-4057qib7 15187 31 ) ) -RRB- cord-005453-4057qib7 15187 32 in in IN cord-005453-4057qib7 15187 33 single single JJ cord-005453-4057qib7 15187 34 - - HYPH cord-005453-4057qib7 15187 35 pediatric pediatric JJ cord-005453-4057qib7 15187 36 transplantation transplantation NN cord-005453-4057qib7 15187 37 center center NN cord-005453-4057qib7 15187 38 . . . cord-005453-4057qib7 15188 1 Results result NNS cord-005453-4057qib7 15188 2 : : : cord-005453-4057qib7 15189 1 The the DT cord-005453-4057qib7 15189 2 cumulative cumulative JJ cord-005453-4057qib7 15189 3 incidence incidence NN cord-005453-4057qib7 15189 4 of of IN cord-005453-4057qib7 15189 5 neutrophil neutrophil NN cord-005453-4057qib7 15189 6 engraftment engraftment NN cord-005453-4057qib7 15189 7 at at IN cord-005453-4057qib7 15189 8 day day NN cord-005453-4057qib7 15189 9 30 30 CD cord-005453-4057qib7 15189 10 in in IN cord-005453-4057qib7 15189 11 Tac Tac NNP cord-005453-4057qib7 15189 12 / / SYM cord-005453-4057qib7 15189 13 mPSL mpsl NN cord-005453-4057qib7 15189 14 group group NN cord-005453-4057qib7 15189 15 was be VBD cord-005453-4057qib7 15189 16 70.1 70.1 CD cord-005453-4057qib7 15189 17 % % NN cord-005453-4057qib7 15189 18 and and CC cord-005453-4057qib7 15189 19 90.3 90.3 CD cord-005453-4057qib7 15189 20 % % NN cord-005453-4057qib7 15189 21 in in IN cord-005453-4057qib7 15189 22 Tac Tac NNP cord-005453-4057qib7 15189 23 / / SYM cord-005453-4057qib7 15189 24 MTX MTX NNP cord-005453-4057qib7 15189 25 group group NN cord-005453-4057qib7 15189 26 ( ( -LRB- cord-005453-4057qib7 15189 27 p=0.09 p=0.09 NNP cord-005453-4057qib7 15189 28 ) ) -RRB- cord-005453-4057qib7 15189 29 . . . cord-005453-4057qib7 15190 1 Median median JJ cord-005453-4057qib7 15190 2 time time NN cord-005453-4057qib7 15190 3 of of IN cord-005453-4057qib7 15190 4 neutrophil neutrophil NN cord-005453-4057qib7 15190 5 engraftment engraftment NN cord-005453-4057qib7 15190 6 was be VBD cord-005453-4057qib7 15190 7 2 2 CD cord-005453-4057qib7 15190 8 days day NNS cord-005453-4057qib7 15190 9 earlier early RBR cord-005453-4057qib7 15190 10 in in IN cord-005453-4057qib7 15190 11 Tac Tac NNP cord-005453-4057qib7 15190 12 / / SYM cord-005453-4057qib7 15190 13 MTX MTX NNP cord-005453-4057qib7 15190 14 group group NN cord-005453-4057qib7 15190 15 ( ( -LRB- cord-005453-4057qib7 15190 16 17 17 CD cord-005453-4057qib7 15190 17 days day NNS cord-005453-4057qib7 15190 18 ) ) -RRB- cord-005453-4057qib7 15190 19 than than IN cord-005453-4057qib7 15190 20 Tac Tac NNP cord-005453-4057qib7 15190 21 / / SYM cord-005453-4057qib7 15190 22 mPSL mpsl NN cord-005453-4057qib7 15190 23 group group NN cord-005453-4057qib7 15190 24 ( ( -LRB- cord-005453-4057qib7 15190 25 19 19 CD cord-005453-4057qib7 15190 26 days day NNS cord-005453-4057qib7 15190 27 ) ) -RRB- cord-005453-4057qib7 15190 28 . . . cord-005453-4057qib7 15191 1 According accord VBG cord-005453-4057qib7 15191 2 to to IN cord-005453-4057qib7 15191 3 PIR PIR NNP cord-005453-4057qib7 15191 4 , , , cord-005453-4057qib7 15191 5 and and CC cord-005453-4057qib7 15191 6 acute acute JJ cord-005453-4057qib7 15191 7 GVHD GVHD NNP cord-005453-4057qib7 15191 8 , , , cord-005453-4057qib7 15191 9 Tac Tac NNP cord-005453-4057qib7 15191 10 / / SYM cord-005453-4057qib7 15191 11 MTX MTX NNP cord-005453-4057qib7 15191 12 group group NN cord-005453-4057qib7 15191 13 showed show VBD cord-005453-4057qib7 15191 14 superior superior JJ cord-005453-4057qib7 15191 15 outcomes outcome NNS cord-005453-4057qib7 15191 16 ; ; : cord-005453-4057qib7 15191 17 the the DT cord-005453-4057qib7 15191 18 incidence incidence NN cord-005453-4057qib7 15191 19 of of IN cord-005453-4057qib7 15191 20 PIR PIR NNP cord-005453-4057qib7 15191 21 ( ( -LRB- cord-005453-4057qib7 15191 22 p=0.020 p=0.020 NNP cord-005453-4057qib7 15191 23 ) ) -RRB- cord-005453-4057qib7 15191 24 and and CC cord-005453-4057qib7 15191 25 the the DT cord-005453-4057qib7 15191 26 cumulative cumulative JJ cord-005453-4057qib7 15191 27 incidences incidence NNS cord-005453-4057qib7 15191 28 of of IN cord-005453-4057qib7 15191 29 acute acute JJ cord-005453-4057qib7 15191 30 GVHD GVHD NNP cord-005453-4057qib7 15191 31 at at IN cord-005453-4057qib7 15191 32 day day NN cord-005453-4057qib7 15191 33 100 100 CD cord-005453-4057qib7 15191 34 ( ( -LRB- cord-005453-4057qib7 15191 35 38.7 38.7 CD cord-005453-4057qib7 15191 36 vs vs IN cord-005453-4057qib7 15191 37 68.8 68.8 CD cord-005453-4057qib7 15191 38 % % NN cord-005453-4057qib7 15191 39 , , , cord-005453-4057qib7 15191 40 p p NN cord-005453-4057qib7 15191 41 = = SYM cord-005453-4057qib7 15191 42 0.045 0.045 CD cord-005453-4057qib7 15191 43 for for IN cord-005453-4057qib7 15191 44 grade grade NN cord-005453-4057qib7 15191 45 II II NNP cord-005453-4057qib7 15191 46 - - HYPH cord-005453-4057qib7 15191 47 IV IV NNP cord-005453-4057qib7 15191 48 , , , cord-005453-4057qib7 15191 49 9.7 9.7 CD cord-005453-4057qib7 15191 50 vs vs IN cord-005453-4057qib7 15191 51 34.4 34.4 CD cord-005453-4057qib7 15191 52 % % NN cord-005453-4057qib7 15191 53 , , , cord-005453-4057qib7 15191 54 p=0.021 p=0.021 NNP cord-005453-4057qib7 15191 55 for for IN cord-005453-4057qib7 15191 56 grade grade NN cord-005453-4057qib7 15191 57 III III NNP cord-005453-4057qib7 15191 58 - - HYPH cord-005453-4057qib7 15191 59 IV IV NNP cord-005453-4057qib7 15191 60 ) ) -RRB- cord-005453-4057qib7 15191 61 was be VBD cord-005453-4057qib7 15191 62 significantly significantly RB cord-005453-4057qib7 15191 63 lower low JJR cord-005453-4057qib7 15191 64 in in IN cord-005453-4057qib7 15191 65 Tac Tac NNP cord-005453-4057qib7 15191 66 / / SYM cord-005453-4057qib7 15191 67 MTX MTX NNP cord-005453-4057qib7 15191 68 group group NN cord-005453-4057qib7 15191 69 than than IN cord-005453-4057qib7 15191 70 in in IN cord-005453-4057qib7 15191 71 Tac Tac NNP cord-005453-4057qib7 15191 72 / / SYM cord-005453-4057qib7 15191 73 mPSL mpsl NN cord-005453-4057qib7 15191 74 . . . cord-005453-4057qib7 15192 1 However however RB cord-005453-4057qib7 15192 2 , , , cord-005453-4057qib7 15192 3 the the DT cord-005453-4057qib7 15192 4 incidences incidence NNS cord-005453-4057qib7 15192 5 of of IN cord-005453-4057qib7 15192 6 relapse relapse NN cord-005453-4057qib7 15192 7 ( ( -LRB- cord-005453-4057qib7 15192 8 p=0.921 p=0.921 NNP cord-005453-4057qib7 15192 9 ) ) -RRB- cord-005453-4057qib7 15192 10 and and CC cord-005453-4057qib7 15192 11 cytomegalovirus cytomegalovirus NNP cord-005453-4057qib7 15192 12 viremia viremia NN cord-005453-4057qib7 15192 13 ( ( -LRB- cord-005453-4057qib7 15192 14 p=0.908 p=0.908 NNP cord-005453-4057qib7 15192 15 ) ) -RRB- cord-005453-4057qib7 15192 16 , , , cord-005453-4057qib7 15192 17 and and CC cord-005453-4057qib7 15192 18 estimated estimate VBN cord-005453-4057qib7 15192 19 overall overall JJ cord-005453-4057qib7 15192 20 survival survival NN cord-005453-4057qib7 15192 21 ( ( -LRB- cord-005453-4057qib7 15192 22 p=0.87 p=0.87 NNP cord-005453-4057qib7 15192 23 ) ) -RRB- cord-005453-4057qib7 15192 24 and and CC cord-005453-4057qib7 15192 25 event event NN cord-005453-4057qib7 15192 26 - - HYPH cord-005453-4057qib7 15192 27 free free JJ cord-005453-4057qib7 15192 28 survival survival NN cord-005453-4057qib7 15192 29 ( ( -LRB- cord-005453-4057qib7 15192 30 p=0.88 p=0.88 NNP cord-005453-4057qib7 15192 31 ) ) -RRB- cord-005453-4057qib7 15192 32 were be VBD cord-005453-4057qib7 15192 33 comparable comparable JJ cord-005453-4057qib7 15192 34 between between IN cord-005453-4057qib7 15192 35 two two CD cord-005453-4057qib7 15192 36 groups group NNS cord-005453-4057qib7 15192 37 . . . cord-005453-4057qib7 15193 1 Conclusions conclusion NNS cord-005453-4057qib7 15193 2 : : : cord-005453-4057qib7 15194 1 Our -PRON- PRP$ cord-005453-4057qib7 15194 2 results result NNS cord-005453-4057qib7 15194 3 indicated indicate VBD cord-005453-4057qib7 15194 4 that that IN cord-005453-4057qib7 15194 5 GVHD GVHD NNP cord-005453-4057qib7 15194 6 prophylaxis prophylaxis NN cord-005453-4057qib7 15194 7 with with IN cord-005453-4057qib7 15194 8 Tac Tac NNP cord-005453-4057qib7 15194 9 / / SYM cord-005453-4057qib7 15194 10 MTX MTX NNP cord-005453-4057qib7 15194 11 had have VBD cord-005453-4057qib7 15194 12 favorable favorable JJ cord-005453-4057qib7 15194 13 effects effect NNS cord-005453-4057qib7 15194 14 ; ; , cord-005453-4057qib7 15194 15 reduced reduce VBN cord-005453-4057qib7 15194 16 incidence incidence NN cord-005453-4057qib7 15194 17 of of IN cord-005453-4057qib7 15194 18 RIP rip NN cord-005453-4057qib7 15194 19 and and CC cord-005453-4057qib7 15194 20 acute acute JJ cord-005453-4057qib7 15194 21 GVHD GVHD NNP cord-005453-4057qib7 15194 22 after after IN cord-005453-4057qib7 15194 23 UCBT UCBT NNP cord-005453-4057qib7 15194 24 without without IN cord-005453-4057qib7 15194 25 any any DT cord-005453-4057qib7 15194 26 negative negative JJ cord-005453-4057qib7 15194 27 influences influence NNS cord-005453-4057qib7 15194 28 . . . cord-005453-4057qib7 15195 1 Disclosure disclosure NN cord-005453-4057qib7 15195 2 : : : cord-005453-4057qib7 15195 3 Nothing nothing NN cord-005453-4057qib7 15195 4 to to TO cord-005453-4057qib7 15195 5 declare declare VB cord-005453-4057qib7 15195 6 Transfer transfer NN cord-005453-4057qib7 15195 7 of of IN cord-005453-4057qib7 15195 8 donor donor NN cord-005453-4057qib7 15195 9 regulatory regulatory JJ cord-005453-4057qib7 15195 10 T T NNP cord-005453-4057qib7 15195 11 - - HYPH cord-005453-4057qib7 15195 12 cellS cellS NNP cord-005453-4057qib7 15195 13 after after IN cord-005453-4057qib7 15195 14 ATG ATG NNP cord-005453-4057qib7 15195 15 reconditioning reconditioning NN cord-005453-4057qib7 15195 16 cures cure NNS cord-005453-4057qib7 15195 17 severe severe JJ cord-005453-4057qib7 15195 18 refractory refractory JJ cord-005453-4057qib7 15195 19 GVHD GVHD NNP cord-005453-4057qib7 15195 20 and and CC cord-005453-4057qib7 15195 21 leads lead VBZ cord-005453-4057qib7 15195 22 to to IN cord-005453-4057qib7 15195 23 long long JJ cord-005453-4057qib7 15195 24 term term NN cord-005453-4057qib7 15195 25 persistence persistence NN cord-005453-4057qib7 15195 26 of of IN cord-005453-4057qib7 15195 27 regulatory regulatory JJ cord-005453-4057qib7 15195 28 T T NNP cord-005453-4057qib7 15195 29 - - HYPH cord-005453-4057qib7 15195 30 cellS cellS NNP cord-005453-4057qib7 15195 31 in in IN cord-005453-4057qib7 15195 32 the the DT cord-005453-4057qib7 15195 33 recipient recipient NN cord-005453-4057qib7 15195 34 cells cell NNS cord-005453-4057qib7 15195 35 on on IN cord-005453-4057qib7 15195 36 a a DT cord-005453-4057qib7 15195 37 CliniMACS CliniMACS NNP cord-005453-4057qib7 15195 38 ® ® NN cord-005453-4057qib7 15195 39 Plus plus CC cord-005453-4057qib7 15195 40 device device NN cord-005453-4057qib7 15195 41 ( ( -LRB- cord-005453-4057qib7 15195 42 Miltenyi Miltenyi NNP cord-005453-4057qib7 15195 43 Biotec Biotec NNP cord-005453-4057qib7 15195 44 ) ) -RRB- cord-005453-4057qib7 15195 45 . . . cord-005453-4057qib7 15196 1 The the DT cord-005453-4057qib7 15196 2 cell cell NN cord-005453-4057qib7 15196 3 product product NN cord-005453-4057qib7 15196 4 contained contain VBD cord-005453-4057qib7 15196 5 83 83 CD cord-005453-4057qib7 15196 6 % % NN cord-005453-4057qib7 15196 7 FoxP3 FoxP3 NNP cord-005453-4057qib7 15196 8 + + CC cord-005453-4057qib7 15196 9 T t NN cord-005453-4057qib7 15196 10 - - HYPH cord-005453-4057qib7 15196 11 cells cell NNS cord-005453-4057qib7 15196 12 . . . cord-005453-4057qib7 15197 1 The the DT cord-005453-4057qib7 15197 2 patient patient NN cord-005453-4057qib7 15197 3 received receive VBD cord-005453-4057qib7 15197 4 3,4x 3,4x CD cord-005453-4057qib7 15197 5 10 10 CD cord-005453-4057qib7 15197 6 5 5 CD cord-005453-4057qib7 15197 7 /kg /kg . cord-005453-4057qib7 15197 8 T T NNP cord-005453-4057qib7 15197 9 reg reg NN cord-005453-4057qib7 15197 10 on on IN cord-005453-4057qib7 15197 11 day day NN cord-005453-4057qib7 15197 12 +177 +177 NNP cord-005453-4057qib7 15197 13 . . . cord-005453-4057qib7 15198 1 Subsequently subsequently RB cord-005453-4057qib7 15198 2 intestinal intestinal JJ cord-005453-4057qib7 15198 3 GvHD GvHD NNP cord-005453-4057qib7 15198 4 decreased decrease VBD cord-005453-4057qib7 15198 5 and and CC cord-005453-4057qib7 15198 6 finally finally RB cord-005453-4057qib7 15198 7 resolved resolve VBN cord-005453-4057qib7 15198 8 . . . cord-005453-4057qib7 15199 1 Three three CD cord-005453-4057qib7 15199 2 months month NNS cord-005453-4057qib7 15199 3 after after IN cord-005453-4057qib7 15199 4 the the DT cord-005453-4057qib7 15199 5 first first JJ cord-005453-4057qib7 15199 6 T T NNP cord-005453-4057qib7 15199 7 reg reg NN cord-005453-4057qib7 15199 8 transfer transfer VB cord-005453-4057qib7 15199 9 the the DT cord-005453-4057qib7 15199 10 patient patient NN cord-005453-4057qib7 15199 11 got get VBD cord-005453-4057qib7 15199 12 a a DT cord-005453-4057qib7 15199 13 second second JJ cord-005453-4057qib7 15199 14 T T NNP cord-005453-4057qib7 15199 15 reg reg NN cord-005453-4057qib7 15199 16 transfer transfer NN cord-005453-4057qib7 15199 17 ( ( -LRB- cord-005453-4057qib7 15199 18 3,4x 3,4x CD cord-005453-4057qib7 15199 19 10 10 CD cord-005453-4057qib7 15199 20 5 5 CD cord-005453-4057qib7 15199 21 /kg /kg NFP cord-005453-4057qib7 15199 22 ) ) -RRB- cord-005453-4057qib7 15199 23 on on IN cord-005453-4057qib7 15199 24 day day NN cord-005453-4057qib7 15200 1 +281 +281 NNP cord-005453-4057qib7 15200 2 due due IN cord-005453-4057qib7 15200 3 to to IN cord-005453-4057qib7 15200 4 decreasing decrease VBG cord-005453-4057qib7 15200 5 T T NNP cord-005453-4057qib7 15200 6 reg reg NN cord-005453-4057qib7 15200 7 levels level NNS cord-005453-4057qib7 15200 8 . . . cord-005453-4057qib7 15201 1 Thereafter Thereafter NNP cord-005453-4057qib7 15201 2 T T NNP cord-005453-4057qib7 15201 3 reg reg NNP cord-005453-4057qib7 15201 4 persisted persist VBD cord-005453-4057qib7 15201 5 and and CC cord-005453-4057qib7 15201 6 there there EX cord-005453-4057qib7 15201 7 was be VBD cord-005453-4057qib7 15201 8 no no DT cord-005453-4057qib7 15201 9 recurrence recurrence NN cord-005453-4057qib7 15201 10 of of IN cord-005453-4057qib7 15201 11 GvHD GvHD NNP cord-005453-4057qib7 15201 12 . . . cord-005453-4057qib7 15202 1 The the DT cord-005453-4057qib7 15202 2 patient patient NN cord-005453-4057qib7 15202 3 is be VBZ cord-005453-4057qib7 15202 4 well well RB cord-005453-4057qib7 15202 5 with with IN cord-005453-4057qib7 15202 6 low low JJ cord-005453-4057qib7 15202 7 dose dose NN cord-005453-4057qib7 15202 8 sirolimus sirolimus NN cord-005453-4057qib7 15202 9 and and CC cord-005453-4057qib7 15202 10 prednisone prednisone NN cord-005453-4057qib7 15202 11 as as IN cord-005453-4057qib7 15202 12 the the DT cord-005453-4057qib7 15202 13 only only JJ cord-005453-4057qib7 15202 14 immunosuppressants immunosuppressant NNS cord-005453-4057qib7 15202 15 and and CC cord-005453-4057qib7 15202 16 is be VBZ cord-005453-4057qib7 15202 17 particularly particularly RB cord-005453-4057qib7 15202 18 recovering recover VBG cord-005453-4057qib7 15202 19 intestinal intestinal JJ cord-005453-4057qib7 15202 20 function function NN cord-005453-4057qib7 15202 21 . . . cord-005453-4057qib7 15203 1 Conclusions conclusion NNS cord-005453-4057qib7 15203 2 : : : cord-005453-4057qib7 15204 1 This this DT cord-005453-4057qib7 15204 2 case case NN cord-005453-4057qib7 15204 3 illustrates illustrate VBZ cord-005453-4057qib7 15204 4 an an DT cord-005453-4057qib7 15204 5 unusually unusually RB cord-005453-4057qib7 15204 6 severe severe JJ cord-005453-4057qib7 15204 7 acute acute JJ cord-005453-4057qib7 15204 8 GvHD gvhd NN cord-005453-4057qib7 15204 9 after after IN cord-005453-4057qib7 15204 10 matched match VBN cord-005453-4057qib7 15204 11 sibling sibling NN cord-005453-4057qib7 15204 12 SCT SCT NNP cord-005453-4057qib7 15204 13 . . . cord-005453-4057qib7 15205 1 Transfer transfer NN cord-005453-4057qib7 15205 2 of of IN cord-005453-4057qib7 15205 3 donorderived donorderived NNP cord-005453-4057qib7 15205 4 T T NNP cord-005453-4057qib7 15205 5 reg reg NNP cord-005453-4057qib7 15205 6 was be VBD cord-005453-4057qib7 15205 7 able able JJ cord-005453-4057qib7 15205 8 to to TO cord-005453-4057qib7 15205 9 cure cure VB cord-005453-4057qib7 15205 10 severe severe JJ cord-005453-4057qib7 15205 11 and and CC cord-005453-4057qib7 15205 12 refractory refractory JJ cord-005453-4057qib7 15205 13 GvHD gvhd NN cord-005453-4057qib7 15205 14 after after IN cord-005453-4057qib7 15205 15 T t NN cord-005453-4057qib7 15205 16 - - HYPH cord-005453-4057qib7 15205 17 cell cell NN cord-005453-4057qib7 15205 18 ablation ablation NN cord-005453-4057qib7 15205 19 by by IN cord-005453-4057qib7 15205 20 ATG ATG NNP cord-005453-4057qib7 15205 21 . . . cord-005453-4057qib7 15206 1 Transferred transfer VBN cord-005453-4057qib7 15206 2 T T NNP cord-005453-4057qib7 15206 3 reg reg NN cord-005453-4057qib7 15206 4 persisted persist VBD cord-005453-4057qib7 15206 5 in in IN cord-005453-4057qib7 15206 6 the the DT cord-005453-4057qib7 15206 7 recipient recipient NN cord-005453-4057qib7 15206 8 for for IN cord-005453-4057qib7 15206 9 a a DT cord-005453-4057qib7 15206 10 long long JJ cord-005453-4057qib7 15206 11 period period NN cord-005453-4057qib7 15206 12 and and CC cord-005453-4057qib7 15206 13 did do VBD cord-005453-4057qib7 15206 14 not not RB cord-005453-4057qib7 15206 15 lead lead VB cord-005453-4057qib7 15206 16 to to IN cord-005453-4057qib7 15206 17 any any DT cord-005453-4057qib7 15206 18 adverse adverse JJ cord-005453-4057qib7 15206 19 Events event NNS cord-005453-4057qib7 15206 20 . . . cord-005453-4057qib7 15207 1 Disclosure disclosure NN cord-005453-4057qib7 15207 2 : : : cord-005453-4057qib7 15207 3 no no DT cord-005453-4057qib7 15207 4 disclosures disclosure NNS cord-005453-4057qib7 15207 5 to to TO cord-005453-4057qib7 15207 6 declaim declaim VB cord-005453-4057qib7 15207 7 Allogeneic Allogeneic NNP cord-005453-4057qib7 15207 8 HSCT HSCT NNP cord-005453-4057qib7 15207 9 for for IN cord-005453-4057qib7 15207 10 patients patient NNS cord-005453-4057qib7 15207 11 with with IN cord-005453-4057qib7 15207 12 transfusion transfusion NN cord-005453-4057qib7 15207 13 dependent dependent JJ cord-005453-4057qib7 15207 14 anemia anemia NN cord-005453-4057qib7 15207 15 from from IN cord-005453-4057qib7 15207 16 matched match VBN cord-005453-4057qib7 15207 17 and and CC cord-005453-4057qib7 15207 18 mismatched mismatched JJ cord-005453-4057qib7 15207 19 donors donor NNS cord-005453-4057qib7 15207 20 Julia Julia NNP cord-005453-4057qib7 15207 21 Fekadu Fekadu NNP cord-005453-4057qib7 15207 22 1 1 CD cord-005453-4057qib7 15207 23 , , , cord-005453-4057qib7 15207 24 Andrea Andrea NNP cord-005453-4057qib7 15207 25 Jarisch Jarisch NNP cord-005453-4057qib7 15207 26 1 1 CD cord-005453-4057qib7 15207 27 , , , cord-005453-4057qib7 15207 28 Jan Jan NNP cord-005453-4057qib7 15207 29 Sörensen Sörensen NNP cord-005453-4057qib7 15207 30 1 1 CD cord-005453-4057qib7 15207 31 , , , cord-005453-4057qib7 15207 32 Emilia Emilia NNP cord-005453-4057qib7 15207 33 Salzmann Salzmann NNP cord-005453-4057qib7 15207 34 1 1 CD cord-005453-4057qib7 15207 35 , , , cord-005453-4057qib7 15207 36 Eva Eva NNP cord-005453-4057qib7 15207 37 Rettinger Rettinger NNP cord-005453-4057qib7 15207 38 1 1 CD cord-005453-4057qib7 15207 39 , , , cord-005453-4057qib7 15207 40 André André NNP cord-005453-4057qib7 15207 41 Willasch Willasch NNP cord-005453-4057qib7 15207 42 1 1 CD cord-005453-4057qib7 15207 43 , , , cord-005453-4057qib7 15207 44 Shahrzad Shahrzad NNP cord-005453-4057qib7 15207 45 Bakhtiar Bakhtiar NNP cord-005453-4057qib7 15207 46 1 1 CD cord-005453-4057qib7 15207 47 , , , cord-005453-4057qib7 15207 48 Thomas Thomas NNP cord-005453-4057qib7 15207 49 Klingebiel Klingebiel NNP cord-005453-4057qib7 15207 50 1 1 CD cord-005453-4057qib7 15207 51 , , , cord-005453-4057qib7 15207 52 Peter Peter NNP cord-005453-4057qib7 15207 53 Bader Bader NNP cord-005453-4057qib7 15207 54 1 1 CD cord-005453-4057qib7 15207 55 after after IN cord-005453-4057qib7 15207 56 first first JJ cord-005453-4057qib7 15207 57 ASCT ASCT NNP cord-005453-4057qib7 15207 58 . . . cord-005453-4057qib7 15208 1 The the DT cord-005453-4057qib7 15208 2 mean mean JJ cord-005453-4057qib7 15208 3 harvest harvest NN cord-005453-4057qib7 15208 4 for for IN cord-005453-4057qib7 15208 5 patients patient NNS cord-005453-4057qib7 15208 6 receiving receive VBG cord-005453-4057qib7 15208 7 DHAP DHAP NNP cord-005453-4057qib7 15208 8 was be VBD cord-005453-4057qib7 15208 9 10,02x10 10,02x10 CD cord-005453-4057qib7 15208 10 6 6 CD cord-005453-4057qib7 15208 11 CD34(+ CD34(+ NNS cord-005453-4057qib7 15208 12 ) ) -RRB- cord-005453-4057qib7 15208 13 cells cell NNS cord-005453-4057qib7 15208 14 / / SYM cord-005453-4057qib7 15208 15 kg kg NNS cord-005453-4057qib7 15208 16 , , , cord-005453-4057qib7 15209 1 3,04 3,04 CD cord-005453-4057qib7 15209 2 x10 x10 CD cord-005453-4057qib7 15209 3 6 6 CD cord-005453-4057qib7 15209 4 CD34 CD34 NNP cord-005453-4057qib7 15209 5 ( ( -LRB- cord-005453-4057qib7 15209 6 + + NNS cord-005453-4057qib7 15209 7 ) ) -RRB- cord-005453-4057qib7 15209 8 cells cell NNS cord-005453-4057qib7 15209 9 / / SYM cord-005453-4057qib7 15209 10 kg kg NNS cord-005453-4057qib7 15209 11 for for IN cord-005453-4057qib7 15209 12 CY CY NNP cord-005453-4057qib7 15209 13 , , , cord-005453-4057qib7 15209 14 8.56 8.56 CD cord-005453-4057qib7 15209 15 x10 x10 CD cord-005453-4057qib7 15209 16 6 6 CD cord-005453-4057qib7 15209 17 CD34(+ cd34(+ JJ cord-005453-4057qib7 15209 18 ) ) -RRB- cord-005453-4057qib7 15209 19 cells cell NNS cord-005453-4057qib7 15209 20 / / SYM cord-005453-4057qib7 15209 21 kg kg NNS cord-005453-4057qib7 15209 22 for for IN cord-005453-4057qib7 15209 23 IGEV IGEV NNP cord-005453-4057qib7 15209 24 , , , cord-005453-4057qib7 15209 25 6,76 6,76 CD cord-005453-4057qib7 15209 26 x10 x10 NN cord-005453-4057qib7 15209 27 6 6 CD cord-005453-4057qib7 15209 28 CD34(+ cd34(+ JJ cord-005453-4057qib7 15209 29 ) ) -RRB- cord-005453-4057qib7 15209 30 cells cell NNS cord-005453-4057qib7 15209 31 / / SYM cord-005453-4057qib7 15209 32 kg kg NN cord-005453-4057qib7 15209 33 for for IN cord-005453-4057qib7 15209 34 ICE ice NN cord-005453-4057qib7 15209 35 , , , cord-005453-4057qib7 15210 1 10,52 10,52 CD cord-005453-4057qib7 15210 2 x10 x10 CD cord-005453-4057qib7 15210 3 6 6 CD cord-005453-4057qib7 15210 4 CD34(+ cd34(+ JJ cord-005453-4057qib7 15210 5 ) ) -RRB- cord-005453-4057qib7 15210 6 cells cell NNS cord-005453-4057qib7 15210 7 / / SYM cord-005453-4057qib7 15210 8 kg kg NNS cord-005453-4057qib7 15210 9 for for IN cord-005453-4057qib7 15210 10 CHOEP CHOEP NNP cord-005453-4057qib7 15210 11 . . . cord-005453-4057qib7 15211 1 The the DT cord-005453-4057qib7 15211 2 patient patient NN cord-005453-4057qib7 15211 3 mobilized mobilize VBD cord-005453-4057qib7 15211 4 with with IN cord-005453-4057qib7 15211 5 VTD VTD NNP cord-005453-4057qib7 15211 6 - - HYPH cord-005453-4057qib7 15211 7 PACE pace NN cord-005453-4057qib7 15211 8 achieved achieve VBD cord-005453-4057qib7 15211 9 2,2 2,2 CD cord-005453-4057qib7 15211 10 x10 x10 CD cord-005453-4057qib7 15211 11 6 6 CD cord-005453-4057qib7 15211 12 CD34(+ cd34(+ JJ cord-005453-4057qib7 15211 13 ) ) -RRB- cord-005453-4057qib7 15211 14 cells cell NNS cord-005453-4057qib7 15211 15 / / SYM cord-005453-4057qib7 15211 16 kg kg NNS cord-005453-4057qib7 15211 17 after after IN cord-005453-4057qib7 15211 18 2 2 CD cord-005453-4057qib7 15211 19 apheresis apheresis NN cord-005453-4057qib7 15211 20 . . . cord-005453-4057qib7 15212 1 19 19 CD cord-005453-4057qib7 15212 2 of of IN cord-005453-4057qib7 15212 3 the the DT cord-005453-4057qib7 15212 4 patients patient NNS cord-005453-4057qib7 15212 5 achieved achieve VBD cord-005453-4057qib7 15212 6 the the DT cord-005453-4057qib7 15212 7 target target NN cord-005453-4057qib7 15212 8 number number NN cord-005453-4057qib7 15212 9 of of IN cord-005453-4057qib7 15212 10 > > XX cord-005453-4057qib7 15213 1 2x10 2x10 CD cord-005453-4057qib7 15213 2 6 6 CD cord-005453-4057qib7 15214 1 /kg /kg . cord-005453-4057qib7 15215 1 CD34 CD34 NNP cord-005453-4057qib7 15215 2 + + CC cord-005453-4057qib7 15215 3 cells cell NNS cord-005453-4057qib7 15215 4 after after IN cord-005453-4057qib7 15215 5 1 1 CD cord-005453-4057qib7 15215 6 apheresis apheresis NN cord-005453-4057qib7 15215 7 , , , cord-005453-4057qib7 15215 8 15 15 CD cord-005453-4057qib7 15215 9 after after IN cord-005453-4057qib7 15215 10 two two CD cord-005453-4057qib7 15215 11 , , , cord-005453-4057qib7 15215 12 and and CC cord-005453-4057qib7 15215 13 2 2 CD cord-005453-4057qib7 15215 14 after after IN cord-005453-4057qib7 15215 15 three three CD cord-005453-4057qib7 15215 16 apheresis apheresis NN cord-005453-4057qib7 15215 17 . . . cord-005453-4057qib7 15216 1 The the DT cord-005453-4057qib7 15216 2 median median JJ cord-005453-4057qib7 15216 3 time time NN cord-005453-4057qib7 15216 4 to to IN cord-005453-4057qib7 15216 5 apheresis apheresis NN cord-005453-4057qib7 15216 6 was be VBD cord-005453-4057qib7 15216 7 13 13 CD cord-005453-4057qib7 15216 8 days day NNS cord-005453-4057qib7 15216 9 ( ( -LRB- cord-005453-4057qib7 15216 10 8 8 CD cord-005453-4057qib7 15216 11 - - SYM cord-005453-4057qib7 15216 12 18 18 CD cord-005453-4057qib7 15216 13 ) ) -RRB- cord-005453-4057qib7 15216 14 without without IN cord-005453-4057qib7 15216 15 significant significant JJ cord-005453-4057qib7 15216 16 difference difference NN cord-005453-4057qib7 15216 17 between between IN cord-005453-4057qib7 15216 18 the the DT cord-005453-4057qib7 15216 19 regimens regimen NNS cord-005453-4057qib7 15216 20 . . . cord-005453-4057qib7 15217 1 The the DT cord-005453-4057qib7 15217 2 mean mean JJ cord-005453-4057qib7 15217 3 WBC WBC NNP cord-005453-4057qib7 15217 4 count count NN cord-005453-4057qib7 15217 5 at at IN cord-005453-4057qib7 15217 6 the the DT cord-005453-4057qib7 15217 7 time time NN cord-005453-4057qib7 15217 8 of of IN cord-005453-4057qib7 15217 9 apheresis apheresis NN cord-005453-4057qib7 15217 10 was be VBD cord-005453-4057qib7 15217 11 42,8x10 42,8x10 CD cord-005453-4057qib7 15217 12 9 9 CD cord-005453-4057qib7 15217 13 /L /L . cord-005453-4057qib7 15217 14 after after IN cord-005453-4057qib7 15217 15 DHAP DHAP NNP cord-005453-4057qib7 15217 16 , , , cord-005453-4057qib7 15217 17 34,5 34,5 CD cord-005453-4057qib7 15217 18 x10 x10 CD cord-005453-4057qib7 15217 19 9 9 CD cord-005453-4057qib7 15217 20 /L /L . cord-005453-4057qib7 15217 21 after after IN cord-005453-4057qib7 15217 22 CY CY NNP cord-005453-4057qib7 15217 23 , , , cord-005453-4057qib7 15217 24 21,2 21,2 CD cord-005453-4057qib7 15217 25 x10 x10 CD cord-005453-4057qib7 15217 26 9 9 CD cord-005453-4057qib7 15217 27 /L /L . cord-005453-4057qib7 15217 28 after after IN cord-005453-4057qib7 15217 29 IGEV IGEV NNP cord-005453-4057qib7 15217 30 , , , cord-005453-4057qib7 15217 31 23,1 23,1 CD cord-005453-4057qib7 15217 32 x10 x10 CD cord-005453-4057qib7 15217 33 9 9 CD cord-005453-4057qib7 15217 34 /L /L . cord-005453-4057qib7 15217 35 after after IN cord-005453-4057qib7 15217 36 ICE ice NN cord-005453-4057qib7 15217 37 , , , cord-005453-4057qib7 15217 38 45,8 45,8 CD cord-005453-4057qib7 15217 39 x10 x10 NN cord-005453-4057qib7 15217 40 9 9 CD cord-005453-4057qib7 15217 41 /L /L . cord-005453-4057qib7 15217 42 after after IN cord-005453-4057qib7 15217 43 CHOEP CHOEP NNP cord-005453-4057qib7 15217 44 . . . cord-005453-4057qib7 15218 1 There there EX cord-005453-4057qib7 15218 2 was be VBD cord-005453-4057qib7 15218 3 correlation correlation NN cord-005453-4057qib7 15218 4 between between IN cord-005453-4057qib7 15218 5 WBC WBC NNP cord-005453-4057qib7 15218 6 and and CC cord-005453-4057qib7 15218 7 CD34 CD34 NNP cord-005453-4057qib7 15218 8 harvested harvest VBD cord-005453-4057qib7 15218 9 cells cell NNS cord-005453-4057qib7 15218 10 ( ( -LRB- cord-005453-4057qib7 15218 11 p=0.005 p=0.005 NNP cord-005453-4057qib7 15218 12 ) ) -RRB- cord-005453-4057qib7 15218 13 . . . cord-005453-4057qib7 15219 1 Grate Grate NNP cord-005453-4057qib7 15219 2 3 3 CD cord-005453-4057qib7 15219 3 - - SYM cord-005453-4057qib7 15219 4 4 4 CD cord-005453-4057qib7 15219 5 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 15219 6 was be VBD cord-005453-4057qib7 15219 7 found find VBN cord-005453-4057qib7 15219 8 in in IN cord-005453-4057qib7 15219 9 8 8 CD cord-005453-4057qib7 15219 10 patient patient NN cord-005453-4057qib7 15219 11 ( ( -LRB- cord-005453-4057qib7 15219 12 5 5 CD cord-005453-4057qib7 15219 13 DHAP DHAP NNP cord-005453-4057qib7 15219 14 , , , cord-005453-4057qib7 15219 15 1 1 CD cord-005453-4057qib7 15219 16 ICE ice NN cord-005453-4057qib7 15219 17 , , , cord-005453-4057qib7 15219 18 1IGEV 1igev CD cord-005453-4057qib7 15219 19 , , , cord-005453-4057qib7 15219 20 1 1 CD cord-005453-4057qib7 15219 21 VTD vtd NN cord-005453-4057qib7 15219 22 - - HYPH cord-005453-4057qib7 15219 23 PACE pace NN cord-005453-4057qib7 15219 24 ) ) -RRB- cord-005453-4057qib7 15219 25 . . . cord-005453-4057qib7 15220 1 Grate Grate NNP cord-005453-4057qib7 15220 2 3 3 CD cord-005453-4057qib7 15220 3 - - SYM cord-005453-4057qib7 15220 4 4 4 CD cord-005453-4057qib7 15220 5 anemia anemia NN cord-005453-4057qib7 15220 6 was be VBD cord-005453-4057qib7 15220 7 registered register VBN cord-005453-4057qib7 15220 8 in in IN cord-005453-4057qib7 15220 9 3 3 CD cord-005453-4057qib7 15220 10 patients patient NNS cord-005453-4057qib7 15220 11 ( ( -LRB- cord-005453-4057qib7 15220 12 2 2 CD cord-005453-4057qib7 15220 13 DHAP DHAP NNS cord-005453-4057qib7 15220 14 and and CC cord-005453-4057qib7 15220 15 1 1 CD cord-005453-4057qib7 15220 16 VTD vtd NN cord-005453-4057qib7 15220 17 - - HYPH cord-005453-4057qib7 15220 18 PACE PACE NNP cord-005453-4057qib7 15220 19 ) ) -RRB- cord-005453-4057qib7 15220 20 . . . cord-005453-4057qib7 15221 1 No no DT cord-005453-4057qib7 15221 2 correlation correlation NN cord-005453-4057qib7 15221 3 was be VBD cord-005453-4057qib7 15221 4 found find VBN cord-005453-4057qib7 15221 5 between between IN cord-005453-4057qib7 15221 6 the the DT cord-005453-4057qib7 15221 7 CD CD NNP cord-005453-4057qib7 15221 8 34 34 CD cord-005453-4057qib7 15221 9 + + SYM cord-005453-4057qib7 15221 10 harvest harvest NN cord-005453-4057qib7 15221 11 and and CC cord-005453-4057qib7 15221 12 the the DT cord-005453-4057qib7 15221 13 age age NN cord-005453-4057qib7 15221 14 , , , cord-005453-4057qib7 15221 15 number number NN cord-005453-4057qib7 15221 16 of of IN cord-005453-4057qib7 15221 17 previous previous JJ cord-005453-4057qib7 15221 18 lines line NNS cord-005453-4057qib7 15222 1 chemotherapy chemotherapy NN cord-005453-4057qib7 15222 2 , , , cord-005453-4057qib7 15222 3 the the DT cord-005453-4057qib7 15222 4 response response NN cord-005453-4057qib7 15222 5 before before IN cord-005453-4057qib7 15222 6 mobilization mobilization NN cord-005453-4057qib7 15222 7 , , , cord-005453-4057qib7 15222 8 the the DT cord-005453-4057qib7 15222 9 type type NN cord-005453-4057qib7 15222 10 of of IN cord-005453-4057qib7 15222 11 the the DT cord-005453-4057qib7 15222 12 lymphoma lymphoma NN cord-005453-4057qib7 15222 13 and and CC cord-005453-4057qib7 15222 14 the the DT cord-005453-4057qib7 15222 15 clinical clinical JJ cord-005453-4057qib7 15222 16 stage stage NN cord-005453-4057qib7 15222 17 . . . cord-005453-4057qib7 15223 1 Conclusions conclusion NNS cord-005453-4057qib7 15223 2 : : : cord-005453-4057qib7 15224 1 Our -PRON- PRP$ cord-005453-4057qib7 15224 2 results result NNS cord-005453-4057qib7 15224 3 demonstrate demonstrate VBP cord-005453-4057qib7 15224 4 that that IN cord-005453-4057qib7 15224 5 the the DT cord-005453-4057qib7 15224 6 chemo chemo NN cord-005453-4057qib7 15224 7 - - HYPH cord-005453-4057qib7 15224 8 G G NNP cord-005453-4057qib7 15224 9 - - HYPH cord-005453-4057qib7 15224 10 CSF csf NN cord-005453-4057qib7 15224 11 protocols protocol NNS cord-005453-4057qib7 15224 12 have have VBP cord-005453-4057qib7 15224 13 comparable comparable JJ cord-005453-4057qib7 15224 14 effectiveness effectiveness NN cord-005453-4057qib7 15224 15 with with IN cord-005453-4057qib7 15224 16 accep- accep- JJ cord-005453-4057qib7 15224 17 Background background NN cord-005453-4057qib7 15224 18 : : : cord-005453-4057qib7 15224 19 Cytomegalovirus Cytomegalovirus NNP cord-005453-4057qib7 15224 20 ( ( -LRB- cord-005453-4057qib7 15224 21 CMV CMV NNP cord-005453-4057qib7 15224 22 ) ) -RRB- cord-005453-4057qib7 15224 23 may may MD cord-005453-4057qib7 15224 24 cause cause VB cord-005453-4057qib7 15224 25 severe severe JJ cord-005453-4057qib7 15224 26 complications complication NNS cord-005453-4057qib7 15224 27 in in IN cord-005453-4057qib7 15224 28 recipients recipient NNS cord-005453-4057qib7 15224 29 of of IN cord-005453-4057qib7 15224 30 allogeneic allogeneic NN cord-005453-4057qib7 15224 31 haematologic haematologic JJ cord-005453-4057qib7 15224 32 stem stem NN cord-005453-4057qib7 15224 33 cell cell NN cord-005453-4057qib7 15224 34 transplantation transplantation NN cord-005453-4057qib7 15224 35 ( ( -LRB- cord-005453-4057qib7 15224 36 alloHSCT alloHSCT NNP cord-005453-4057qib7 15224 37 ) ) -RRB- cord-005453-4057qib7 15224 38 . . . cord-005453-4057qib7 15225 1 Letermovir Letermovir NNP cord-005453-4057qib7 15225 2 ( ( -LRB- cord-005453-4057qib7 15225 3 LTV LTV NNP cord-005453-4057qib7 15225 4 , , , cord-005453-4057qib7 15225 5 480/ 480/ CD cord-005453-4057qib7 15225 6 240 240 CD cord-005453-4057qib7 15225 7 mg mg NNP cord-005453-4057qib7 15225 8 daily daily RB cord-005453-4057qib7 15225 9 without without IN cord-005453-4057qib7 15225 10 / / SYM cord-005453-4057qib7 15225 11 with with IN cord-005453-4057qib7 15225 12 co co NN cord-005453-4057qib7 15225 13 - - NN cord-005453-4057qib7 15225 14 administration administration NN cord-005453-4057qib7 15225 15 of of IN cord-005453-4057qib7 15225 16 Cyclosporine Cyclosporine NNP cord-005453-4057qib7 15225 17 ) ) -RRB- cord-005453-4057qib7 15225 18 was be VBD cord-005453-4057qib7 15225 19 recently recently RB cord-005453-4057qib7 15225 20 licenced licence VBN cord-005453-4057qib7 15225 21 only only RB cord-005453-4057qib7 15225 22 for for IN cord-005453-4057qib7 15225 23 CMV CMV NNP cord-005453-4057qib7 15225 24 prophylaxis prophylaxis NN cord-005453-4057qib7 15225 25 in in IN cord-005453-4057qib7 15225 26 adult adult NN cord-005453-4057qib7 15225 27 alloHSCT allohsct NN cord-005453-4057qib7 15225 28 - - HYPH cord-005453-4057qib7 15225 29 recipients recipient NNS cord-005453-4057qib7 15225 30 . . . cord-005453-4057qib7 15226 1 Paediatric paediatric JJ cord-005453-4057qib7 15226 2 data datum NNS cord-005453-4057qib7 15226 3 as as RB cord-005453-4057qib7 15226 4 well well RB cord-005453-4057qib7 15226 5 as as IN cord-005453-4057qib7 15226 6 data datum NNS cord-005453-4057qib7 15226 7 on on IN cord-005453-4057qib7 15226 8 CMV CMV NNP cord-005453-4057qib7 15226 9 therapy therapy NN cord-005453-4057qib7 15226 10 are be VBP cord-005453-4057qib7 15226 11 missing miss VBG cord-005453-4057qib7 15226 12 so so RB cord-005453-4057qib7 15226 13 far far RB cord-005453-4057qib7 15226 14 . . . cord-005453-4057qib7 15227 1 Methods method NNS cord-005453-4057qib7 15227 2 : : : cord-005453-4057qib7 15228 1 We -PRON- PRP cord-005453-4057qib7 15228 2 administered administer VBD cord-005453-4057qib7 15228 3 letermovir letermovir NNP cord-005453-4057qib7 15228 4 240 240 CD cord-005453-4057qib7 15228 5 mg mg NNS cord-005453-4057qib7 15228 6 orally orally RB cord-005453-4057qib7 15228 7 once once RB cord-005453-4057qib7 15228 8 daily daily RB cord-005453-4057qib7 15228 9 ( ( -LRB- cord-005453-4057qib7 15228 10 with with IN cord-005453-4057qib7 15228 11 no no DT cord-005453-4057qib7 15228 12 co co NN cord-005453-4057qib7 15228 13 - - NN cord-005453-4057qib7 15228 14 administration administration NN cord-005453-4057qib7 15228 15 of of IN cord-005453-4057qib7 15228 16 Cyclosporine Cyclosporine NNP cord-005453-4057qib7 15228 17 A A NNP cord-005453-4057qib7 15228 18 ) ) -RRB- cord-005453-4057qib7 15228 19 to to IN cord-005453-4057qib7 15228 20 2 2 CD cord-005453-4057qib7 15228 21 paediatric paediatric JJ cord-005453-4057qib7 15228 22 patients patient NNS cord-005453-4057qib7 15228 23 after after IN cord-005453-4057qib7 15228 24 alloHSCT alloHSCT NNP cord-005453-4057qib7 15228 25 . . . cord-005453-4057qib7 15229 1 EDTA edta NN cord-005453-4057qib7 15229 2 - - HYPH cord-005453-4057qib7 15229 3 plasma plasma NN cord-005453-4057qib7 15229 4 were be VBD cord-005453-4057qib7 15229 5 occasionally occasionally RB cord-005453-4057qib7 15229 6 obtained obtain VBN cord-005453-4057qib7 15229 7 at at IN cord-005453-4057qib7 15229 8 different different JJ cord-005453-4057qib7 15229 9 time time NN cord-005453-4057qib7 15229 10 points point NNS cord-005453-4057qib7 15229 11 and and CC cord-005453-4057qib7 15229 12 frozen freeze VBN cord-005453-4057qib7 15229 13 for for IN cord-005453-4057qib7 15229 14 determination determination NN cord-005453-4057qib7 15229 15 of of IN cord-005453-4057qib7 15229 16 letermovir letermovir NNS cord-005453-4057qib7 15229 17 levels level NNS cord-005453-4057qib7 15229 18 using use VBG cord-005453-4057qib7 15229 19 liquid liquid JJ cord-005453-4057qib7 15229 20 chromatography chromatography NN cord-005453-4057qib7 15229 21 / / SYM cord-005453-4057qib7 15229 22 mass mass NN cord-005453-4057qib7 15229 23 spectrometry spectrometry NN cord-005453-4057qib7 15229 24 ( ( -LRB- cord-005453-4057qib7 15229 25 LC LC NNP cord-005453-4057qib7 15229 26 - - HYPH cord-005453-4057qib7 15229 27 MS MS NNP cord-005453-4057qib7 15229 28 / / SYM cord-005453-4057qib7 15229 29 MS MS NNP cord-005453-4057qib7 15229 30 ) ) -RRB- cord-005453-4057qib7 15229 31 . . . cord-005453-4057qib7 15230 1 Results result NNS cord-005453-4057qib7 15230 2 : : : cord-005453-4057qib7 15231 1 For for IN cord-005453-4057qib7 15231 2 details detail NNS cord-005453-4057qib7 15231 3 on on IN cord-005453-4057qib7 15231 4 patients patient NNS cord-005453-4057qib7 15231 5 , , , cord-005453-4057qib7 15231 6 treatment treatment NN cord-005453-4057qib7 15231 7 and and CC cord-005453-4057qib7 15231 8 CMV CMV NNP cord-005453-4057qib7 15231 9 load load NN cord-005453-4057qib7 15231 10 see see VBP cord-005453-4057qib7 15231 11 table table NN cord-005453-4057qib7 15231 12 1 1 CD cord-005453-4057qib7 15231 13 . . . cord-005453-4057qib7 15232 1 In in IN cord-005453-4057qib7 15232 2 short short JJ cord-005453-4057qib7 15232 3 periods period NNS cord-005453-4057qib7 15232 4 of of IN cord-005453-4057qib7 15232 5 letermovir letermovir NNP cord-005453-4057qib7 15232 6 administration administration NN cord-005453-4057qib7 15232 7 , , , cord-005453-4057qib7 15232 8 CMV CMV NNP cord-005453-4057qib7 15232 9 blood blood NN cord-005453-4057qib7 15232 10 levels level NNS cord-005453-4057qib7 15232 11 became become VBD cord-005453-4057qib7 15232 12 negative negative JJ cord-005453-4057qib7 15232 13 in in IN cord-005453-4057qib7 15232 14 both both DT cord-005453-4057qib7 15232 15 patients patient NNS cord-005453-4057qib7 15232 16 . . . cord-005453-4057qib7 15233 1 Considering consider VBG cord-005453-4057qib7 15233 2 the the DT cord-005453-4057qib7 15233 3 lacking lacking JJ cord-005453-4057qib7 15233 4 safety safety NN cord-005453-4057qib7 15233 5 data datum NNS cord-005453-4057qib7 15233 6 in in IN cord-005453-4057qib7 15233 7 paediatric paediatric JJ cord-005453-4057qib7 15233 8 patients patient NNS cord-005453-4057qib7 15233 9 , , , cord-005453-4057qib7 15233 10 we -PRON- PRP cord-005453-4057qib7 15233 11 stopped stop VBD cord-005453-4057qib7 15233 12 letermovir letermovir NNP cord-005453-4057qib7 15233 13 treatment treatment NN cord-005453-4057qib7 15233 14 in in IN cord-005453-4057qib7 15233 15 both both DT cord-005453-4057qib7 15233 16 patients patient NNS cord-005453-4057qib7 15233 17 , , , cord-005453-4057qib7 15233 18 when when WRB cord-005453-4057qib7 15233 19 liver liver NN cord-005453-4057qib7 15233 20 parameters parameter NNS cord-005453-4057qib7 15233 21 increased increase VBD cord-005453-4057qib7 15233 22 . . . cord-005453-4057qib7 15234 1 In in IN cord-005453-4057qib7 15234 2 patient patient NN cord-005453-4057qib7 15234 3 1 1 CD cord-005453-4057qib7 15234 4 hepatopathy hepatopathy NN cord-005453-4057qib7 15234 5 turned turn VBD cord-005453-4057qib7 15234 6 out out RP cord-005453-4057qib7 15234 7 to to TO cord-005453-4057qib7 15234 8 represent represent VB cord-005453-4057qib7 15234 9 histologically histologically RB cord-005453-4057qib7 15234 10 proven prove VBN cord-005453-4057qib7 15234 11 Graft graft NN cord-005453-4057qib7 15234 12 versus versus IN cord-005453-4057qib7 15234 13 Host Host NNP cord-005453-4057qib7 15234 14 Disease Disease NNP cord-005453-4057qib7 15234 15 ( ( -LRB- cord-005453-4057qib7 15234 16 GvHD GvHD NNP cord-005453-4057qib7 15234 17 ) ) -RRB- cord-005453-4057qib7 15234 18 . . . cord-005453-4057qib7 15235 1 In in IN cord-005453-4057qib7 15235 2 patient patient JJ cord-005453-4057qib7 15235 3 2 2 CD cord-005453-4057qib7 15235 4 liver liver NN cord-005453-4057qib7 15235 5 parameters parameter NNS cord-005453-4057qib7 15235 6 further further RB cord-005453-4057qib7 15235 7 increased increase VBD cord-005453-4057qib7 15235 8 despite despite IN cord-005453-4057qib7 15235 9 withdrawal withdrawal NN cord-005453-4057qib7 15235 10 for for IN cord-005453-4057qib7 15235 11 another another DT cord-005453-4057qib7 15235 12 4 4 CD cord-005453-4057qib7 15235 13 weeks week NNS cord-005453-4057qib7 15235 14 , , , cord-005453-4057qib7 15235 15 however however RB cord-005453-4057qib7 15235 16 , , , cord-005453-4057qib7 15235 17 hepatopathy hepatopathy NNP cord-005453-4057qib7 15235 18 was be VBD cord-005453-4057qib7 15235 19 only only RB cord-005453-4057qib7 15235 20 mild mild JJ cord-005453-4057qib7 15235 21 and and CC cord-005453-4057qib7 15235 22 self self NN cord-005453-4057qib7 15235 23 - - HYPH cord-005453-4057qib7 15235 24 limiting limit VBG cord-005453-4057qib7 15235 25 . . . cord-005453-4057qib7 15236 1 Both both DT cord-005453-4057qib7 15236 2 patients patient NNS cord-005453-4057qib7 15236 3 additionally additionally RB cord-005453-4057qib7 15236 4 received receive VBD cord-005453-4057qib7 15236 5 other other JJ cord-005453-4057qib7 15236 6 possibly possibly RB cord-005453-4057qib7 15236 7 hepatotoxic hepatotoxic JJ cord-005453-4057qib7 15236 8 substances substance NNS cord-005453-4057qib7 15236 9 ( ( -LRB- cord-005453-4057qib7 15236 10 mycophenolate mycophenolate NNP cord-005453-4057qib7 15236 11 mofetil mofetil NNP cord-005453-4057qib7 15236 12 and and CC cord-005453-4057qib7 15236 13 trimethoprim/ trimethoprim/ CD cord-005453-4057qib7 15236 14 sulfamethoxazole sulfamethoxazole NNP cord-005453-4057qib7 15236 15 ) ) -RRB- cord-005453-4057qib7 15236 16 . . . cord-005453-4057qib7 15237 1 Letermovir Letermovir NNP cord-005453-4057qib7 15237 2 plasma plasma NN cord-005453-4057qib7 15237 3 levels level NNS cord-005453-4057qib7 15237 4 were be VBD cord-005453-4057qib7 15237 5 11.900ng 11.900ng CD cord-005453-4057qib7 15237 6 / / SYM cord-005453-4057qib7 15237 7 mL ml NN cord-005453-4057qib7 15237 8 ( ( -LRB- cord-005453-4057qib7 15237 9 2h 2h NNP cord-005453-4057qib7 15237 10 ) ) -RRB- cord-005453-4057qib7 15237 11 , , , cord-005453-4057qib7 15237 12 11.600ng 11.600ng CD cord-005453-4057qib7 15237 13 / / SYM cord-005453-4057qib7 15237 14 mL ml NN cord-005453-4057qib7 15237 15 ( ( -LRB- cord-005453-4057qib7 15237 16 12h 12h CD cord-005453-4057qib7 15237 17 ) ) -RRB- cord-005453-4057qib7 15237 18 , , , cord-005453-4057qib7 15237 19 1.640 1.640 CD cord-005453-4057qib7 15237 20 - - SYM cord-005453-4057qib7 15237 21 2.190ng 2.190ng CD cord-005453-4057qib7 15237 22 / / SYM cord-005453-4057qib7 15237 23 mL ml NN cord-005453-4057qib7 15237 24 ( ( -LRB- cord-005453-4057qib7 15237 25 median median NN cord-005453-4057qib7 15237 26 1.990ng/ 1.990ng/ CD cord-005453-4057qib7 15237 27 mL ml NN cord-005453-4057qib7 15237 28 , , , cord-005453-4057qib7 15237 29 n=3 n=3 NN cord-005453-4057qib7 15237 30 , , , cord-005453-4057qib7 15237 31 24h 24h CD cord-005453-4057qib7 15237 32 ) ) -RRB- cord-005453-4057qib7 15237 33 and and CC cord-005453-4057qib7 15237 34 1.050 1.050 CD cord-005453-4057qib7 15237 35 ng ng NN cord-005453-4057qib7 15237 36 / / SYM cord-005453-4057qib7 15237 37 mL ml NN cord-005453-4057qib7 15237 38 ( ( -LRB- cord-005453-4057qib7 15237 39 36h 36h CD cord-005453-4057qib7 15237 40 after after IN cord-005453-4057qib7 15237 41 administration administration NN cord-005453-4057qib7 15237 42 ) ) -RRB- cord-005453-4057qib7 15237 43 . . . cord-005453-4057qib7 15238 1 Conclusions conclusion NNS cord-005453-4057qib7 15238 2 : : : cord-005453-4057qib7 15239 1 During during IN cord-005453-4057qib7 15239 2 short short JJ cord-005453-4057qib7 15239 3 letermovir letermovir NNS cord-005453-4057qib7 15239 4 treatment treatment NN cord-005453-4057qib7 15239 5 , , , cord-005453-4057qib7 15239 6 we -PRON- PRP cord-005453-4057qib7 15239 7 observed observe VBD cord-005453-4057qib7 15239 8 fast fast JJ cord-005453-4057qib7 15239 9 resolution resolution NN cord-005453-4057qib7 15239 10 of of IN cord-005453-4057qib7 15239 11 CMV CMV NNP cord-005453-4057qib7 15239 12 viraemia viraemia NN cord-005453-4057qib7 15239 13 as as RB cord-005453-4057qib7 15239 14 well well RB cord-005453-4057qib7 15239 15 as as IN cord-005453-4057qib7 15239 16 rising rise VBG cord-005453-4057qib7 15239 17 liver liver NN cord-005453-4057qib7 15239 18 parameters parameter NNS cord-005453-4057qib7 15239 19 in in IN cord-005453-4057qib7 15239 20 both both DT cord-005453-4057qib7 15239 21 patients patient NNS cord-005453-4057qib7 15239 22 . . . cord-005453-4057qib7 15240 1 While while IN cord-005453-4057qib7 15240 2 elevated elevated JJ cord-005453-4057qib7 15240 3 liver liver NN cord-005453-4057qib7 15240 4 parameters parameter NNS cord-005453-4057qib7 15240 5 represented represent VBD cord-005453-4057qib7 15240 6 GvHD GvHD NNP cord-005453-4057qib7 15240 7 in in IN cord-005453-4057qib7 15240 8 1 1 CD cord-005453-4057qib7 15240 9 patient patient NN cord-005453-4057qib7 15240 10 , , , cord-005453-4057qib7 15240 11 a a DT cord-005453-4057qib7 15240 12 causal causal JJ cord-005453-4057qib7 15240 13 relationship relationship NN cord-005453-4057qib7 15240 14 with with IN cord-005453-4057qib7 15240 15 letermovir letermovir NNS cord-005453-4057qib7 15240 16 might may MD cord-005453-4057qib7 15240 17 be be VB cord-005453-4057qib7 15240 18 considered consider VBN cord-005453-4057qib7 15240 19 in in IN cord-005453-4057qib7 15240 20 the the DT cord-005453-4057qib7 15240 21 other other JJ cord-005453-4057qib7 15240 22 patient patient NN cord-005453-4057qib7 15240 23 . . . cord-005453-4057qib7 15241 1 Letermovir Letermovir NNP cord-005453-4057qib7 15241 2 peak peak NN cord-005453-4057qib7 15241 3 levels level NNS cord-005453-4057qib7 15241 4 after after IN cord-005453-4057qib7 15241 5 administration administration NN cord-005453-4057qib7 15241 6 of of IN cord-005453-4057qib7 15241 7 240 240 CD cord-005453-4057qib7 15241 8 mg mg NNS cord-005453-4057qib7 15241 9 were be VBD cord-005453-4057qib7 15241 10 within within IN cord-005453-4057qib7 15241 11 ranges range NNS cord-005453-4057qib7 15241 12 reported report VBN cord-005453-4057qib7 15241 13 in in IN cord-005453-4057qib7 15241 14 adults adult NNS cord-005453-4057qib7 15241 15 after after IN cord-005453-4057qib7 15241 16 administration administration NN cord-005453-4057qib7 15241 17 of of IN cord-005453-4057qib7 15241 18 480 480 CD cord-005453-4057qib7 15241 19 mg mg NN cord-005453-4057qib7 15241 20 while while IN cord-005453-4057qib7 15241 21 trough trough NN cord-005453-4057qib7 15241 22 levels level NNS cord-005453-4057qib7 15241 23 were be VBD cord-005453-4057qib7 15241 24 higher high JJR cord-005453-4057qib7 15241 25 indicating indicate VBG cord-005453-4057qib7 15241 26 differences difference NNS cord-005453-4057qib7 15241 27 in in IN cord-005453-4057qib7 15241 28 pharmacokinetics pharmacokinetic NNS cord-005453-4057qib7 15241 29 in in IN cord-005453-4057qib7 15241 30 terms term NNS cord-005453-4057qib7 15241 31 of of IN cord-005453-4057qib7 15241 32 delayed delayed JJ cord-005453-4057qib7 15241 33 clearance clearance NN cord-005453-4057qib7 15241 34 . . . cord-005453-4057qib7 15242 1 inguinal inguinal JJ cord-005453-4057qib7 15242 2 lymphadenomegaly lymphadenomegaly NNP cord-005453-4057qib7 15242 3 . . . cord-005453-4057qib7 15243 1 After after IN cord-005453-4057qib7 15243 2 failure failure NN cord-005453-4057qib7 15243 3 to to TO cord-005453-4057qib7 15243 4 respond respond VB cord-005453-4057qib7 15243 5 to to IN cord-005453-4057qib7 15243 6 seven seven CD cord-005453-4057qib7 15243 7 conventional conventional JJ cord-005453-4057qib7 15243 8 treatment treatment NN cord-005453-4057qib7 15243 9 lines line NNS cord-005453-4057qib7 15243 10 : : : cord-005453-4057qib7 15243 11 methotrexate methotrexate NNP cord-005453-4057qib7 15243 12 , , , cord-005453-4057qib7 15243 13 COP cop NN cord-005453-4057qib7 15243 14 ( ( -LRB- cord-005453-4057qib7 15243 15 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 15243 16 , , , cord-005453-4057qib7 15243 17 vincristin vincristin NNS cord-005453-4057qib7 15243 18 and and CC cord-005453-4057qib7 15243 19 prednisone prednisone NNP cord-005453-4057qib7 15243 20 ) ) -RRB- cord-005453-4057qib7 15243 21 ; ; : cord-005453-4057qib7 15243 22 gemcitabine gemcitabine NNP cord-005453-4057qib7 15243 23 ; ; : cord-005453-4057qib7 15243 24 PUVA PUVA NNP cord-005453-4057qib7 15243 25 ; ; : cord-005453-4057qib7 15243 26 interferon interferon NN cord-005453-4057qib7 15243 27 ; ; : cord-005453-4057qib7 15243 28 acitretin acitretin NNP cord-005453-4057qib7 15243 29 and and CC cord-005453-4057qib7 15243 30 extracorporeal extracorporeal JJ cord-005453-4057qib7 15243 31 photopheresis photopheresis NNP cord-005453-4057qib7 15243 32 ) ) -RRB- cord-005453-4057qib7 15243 33 , , , cord-005453-4057qib7 15243 34 allogeneic allogeneic IN cord-005453-4057qib7 15243 35 HSCT HSCT NNP cord-005453-4057qib7 15243 36 from from IN cord-005453-4057qib7 15243 37 an an DT cord-005453-4057qib7 15243 38 identical identical JJ cord-005453-4057qib7 15243 39 HLA HLA NNP cord-005453-4057qib7 15243 40 male male JJ cord-005453-4057qib7 15243 41 donor donor NN cord-005453-4057qib7 15243 42 was be VBD cord-005453-4057qib7 15243 43 indicated indicate VBN cord-005453-4057qib7 15243 44 . . . cord-005453-4057qib7 15244 1 The the DT cord-005453-4057qib7 15244 2 non non JJ cord-005453-4057qib7 15244 3 - - JJ cord-005453-4057qib7 15244 4 myeloablative myeloablative JJ cord-005453-4057qib7 15244 5 conditioning conditioning NN cord-005453-4057qib7 15244 6 consisted consist VBD cord-005453-4057qib7 15244 7 of of IN cord-005453-4057qib7 15244 8 fludarabine fludarabine NN cord-005453-4057qib7 15244 9 ( ( -LRB- cord-005453-4057qib7 15244 10 200 200 CD cord-005453-4057qib7 15244 11 mg mg NNP cord-005453-4057qib7 15244 12 / / SYM cord-005453-4057qib7 15244 13 m2 m2 NNP cord-005453-4057qib7 15244 14 ) ) -RRB- cord-005453-4057qib7 15244 15 , , , cord-005453-4057qib7 15244 16 cyclophosphamide cyclophosphamide FW cord-005453-4057qib7 15244 17 ( ( -LRB- cord-005453-4057qib7 15244 18 50 50 CD cord-005453-4057qib7 15244 19 mg mg NNP cord-005453-4057qib7 15244 20 / / SYM cord-005453-4057qib7 15244 21 kg kg NNP cord-005453-4057qib7 15244 22 ) ) -RRB- cord-005453-4057qib7 15244 23 and and CC cord-005453-4057qib7 15244 24 total total JJ cord-005453-4057qib7 15244 25 body body NN cord-005453-4057qib7 15244 26 irradiation(TBI irradiation(tbi NN cord-005453-4057qib7 15244 27 ) ) -RRB- cord-005453-4057qib7 15245 1 ( ( -LRB- cord-005453-4057qib7 15245 2 400cGy 400cgy CD cord-005453-4057qib7 15245 3 ) ) -RRB- cord-005453-4057qib7 15245 4 . . . cord-005453-4057qib7 15246 1 Prophylaxis prophylaxis NN cord-005453-4057qib7 15246 2 of of IN cord-005453-4057qib7 15246 3 graft graft NN cord-005453-4057qib7 15246 4 versus versus IN cord-005453-4057qib7 15246 5 host host NN cord-005453-4057qib7 15246 6 disease disease NN cord-005453-4057qib7 15246 7 ( ( -LRB- cord-005453-4057qib7 15246 8 GVHD GVHD NNP cord-005453-4057qib7 15246 9 ) ) -RRB- cord-005453-4057qib7 15246 10 was be VBD cord-005453-4057qib7 15246 11 performed perform VBN cord-005453-4057qib7 15246 12 with with IN cord-005453-4057qib7 15246 13 cyclosporine cyclosporine NN cord-005453-4057qib7 15246 14 ( ( -LRB- cord-005453-4057qib7 15246 15 3 3 CD cord-005453-4057qib7 15246 16 mg mg NN cord-005453-4057qib7 15246 17 / / SYM cord-005453-4057qib7 15246 18 kg kg NNP cord-005453-4057qib7 15246 19 ) ) -RRB- cord-005453-4057qib7 15246 20 and and CC cord-005453-4057qib7 15246 21 mycophenolate mycophenolate NNP cord-005453-4057qib7 15246 22 mofetil mofetil NNP cord-005453-4057qib7 15246 23 ( ( -LRB- cord-005453-4057qib7 15246 24 30mg 30mg NNP cord-005453-4057qib7 15246 25 / / SYM cord-005453-4057qib7 15246 26 kg kg NNP cord-005453-4057qib7 15246 27 ) ) -RRB- cord-005453-4057qib7 15246 28 . . . cord-005453-4057qib7 15247 1 After after IN cord-005453-4057qib7 15247 2 conditioning conditioning NN cord-005453-4057qib7 15247 3 , , , cord-005453-4057qib7 15247 4 there there EX cord-005453-4057qib7 15247 5 was be VBD cord-005453-4057qib7 15247 6 improvement improvement NN cord-005453-4057qib7 15247 7 of of IN cord-005453-4057qib7 15247 8 pruritus pruritus NN cord-005453-4057qib7 15247 9 and and CC cord-005453-4057qib7 15247 10 involution involution NN cord-005453-4057qib7 15247 11 of of IN cord-005453-4057qib7 15247 12 the the DT cord-005453-4057qib7 15247 13 skin skin NN cord-005453-4057qib7 15247 14 . . . cord-005453-4057qib7 15248 1 Bone bone NN cord-005453-4057qib7 15248 2 marrow marrow NN cord-005453-4057qib7 15248 3 infusion infusion NN cord-005453-4057qib7 15248 4 occurred occur VBD cord-005453-4057qib7 15248 5 on on IN cord-005453-4057qib7 15248 6 2/9/2018 2/9/2018 CD cord-005453-4057qib7 15248 7 ( ( -LRB- cord-005453-4057qib7 15248 8 D0 D0 NNP cord-005453-4057qib7 15248 9 ) ) -RRB- cord-005453-4057qib7 15248 10 . . . cord-005453-4057qib7 15249 1 On on IN cord-005453-4057qib7 15249 2 d d XX cord-005453-4057qib7 15249 3 + + SYM cord-005453-4057qib7 15249 4 83 83 CD cord-005453-4057qib7 15249 5 he -PRON- PRP cord-005453-4057qib7 15249 6 presented present VBD cord-005453-4057qib7 15249 7 recurrence recurrence NN cord-005453-4057qib7 15249 8 of of IN cord-005453-4057qib7 15249 9 skin skin NN cord-005453-4057qib7 15249 10 lesions lesion NNS cord-005453-4057qib7 15249 11 of of IN cord-005453-4057qib7 15249 12 fMF fmf CD cord-005453-4057qib7 15249 13 . . . cord-005453-4057qib7 15250 1 Donor donor NN cord-005453-4057qib7 15250 2 lymphocyte lymphocyte NN cord-005453-4057qib7 15250 3 infusion infusion NN cord-005453-4057qib7 15250 4 ( ( -LRB- cord-005453-4057qib7 15250 5 DLI DLI NNP cord-005453-4057qib7 15250 6 ) ) -RRB- cord-005453-4057qib7 15250 7 was be VBD cord-005453-4057qib7 15250 8 performed perform VBN cord-005453-4057qib7 15250 9 ( ( -LRB- cord-005453-4057qib7 15250 10 1 1 CD cord-005453-4057qib7 15250 11 x x SYM cord-005453-4057qib7 15250 12 10 10 CD cord-005453-4057qib7 15250 13 7 7 CD cord-005453-4057qib7 15250 14 CD3 CD3 NNS cord-005453-4057qib7 15250 15 + + CC cord-005453-4057qib7 15250 16 cells cell NNS cord-005453-4057qib7 15250 17 / / SYM cord-005453-4057qib7 15250 18 kg kg NN cord-005453-4057qib7 15250 19 / / SYM cord-005453-4057qib7 15250 20 recipient recipient NN cord-005453-4057qib7 15250 21 ) ) -RRB- cord-005453-4057qib7 15250 22 . . . cord-005453-4057qib7 15251 1 He -PRON- PRP cord-005453-4057qib7 15251 2 presented present VBD cord-005453-4057qib7 15251 3 oral oral JJ cord-005453-4057qib7 15251 4 lichen lichen NN cord-005453-4057qib7 15251 5 and and CC cord-005453-4057qib7 15251 6 diarrhea diarrhea NN cord-005453-4057qib7 15251 7 respectively respectively RB cord-005453-4057qib7 15251 8 as as IN cord-005453-4057qib7 15251 9 manifestations manifestation NNS cord-005453-4057qib7 15251 10 of of IN cord-005453-4057qib7 15251 11 GVHD GVHD NNP cord-005453-4057qib7 15251 12 on on IN cord-005453-4057qib7 15251 13 d d NN cord-005453-4057qib7 15251 14 + + SYM cord-005453-4057qib7 15251 15 104 104 CD cord-005453-4057qib7 15251 16 and and CC cord-005453-4057qib7 15251 17 D d NN cord-005453-4057qib7 15251 18 + + SYM cord-005453-4057qib7 15251 19 112 112 CD cord-005453-4057qib7 15251 20 . . . cord-005453-4057qib7 15252 1 As as IN cord-005453-4057qib7 15252 2 infectious infectious JJ cord-005453-4057qib7 15252 3 intercurrence intercurrence NN cord-005453-4057qib7 15252 4 , , , cord-005453-4057qib7 15252 5 hemorrhagic hemorrhagic JJ cord-005453-4057qib7 15252 6 cystitis cystitis NN cord-005453-4057qib7 15252 7 occurred occur VBD cord-005453-4057qib7 15252 8 by by IN cord-005453-4057qib7 15252 9 BK BK NNP cord-005453-4057qib7 15252 10 virus virus NN cord-005453-4057qib7 15252 11 3 3 CD cord-005453-4057qib7 15252 12 months month NNS cord-005453-4057qib7 15252 13 after after IN cord-005453-4057qib7 15252 14 the the DT cord-005453-4057qib7 15252 15 first first JJ cord-005453-4057qib7 15252 16 DLI DLI NNP cord-005453-4057qib7 15252 17 and and CC cord-005453-4057qib7 15252 18 he -PRON- PRP cord-005453-4057qib7 15252 19 received receive VBD cord-005453-4057qib7 15252 20 conservative conservative JJ cord-005453-4057qib7 15252 21 treatment treatment NN cord-005453-4057qib7 15252 22 and and CC cord-005453-4057qib7 15252 23 remained remain VBD cord-005453-4057qib7 15252 24 without without IN cord-005453-4057qib7 15252 25 systemic systemic JJ cord-005453-4057qib7 15252 26 immunosuppression immunosuppression NN cord-005453-4057qib7 15252 27 . . . cord-005453-4057qib7 15253 1 Nine nine CD cord-005453-4057qib7 15253 2 months month NNS cord-005453-4057qib7 15253 3 after after IN cord-005453-4057qib7 15253 4 HSCT HSCT NNP cord-005453-4057qib7 15253 5 , , , cord-005453-4057qib7 15253 6 a a DT cord-005453-4057qib7 15253 7 second second JJ cord-005453-4057qib7 15253 8 DLI DLI NNP cord-005453-4057qib7 15253 9 ( ( -LRB- cord-005453-4057qib7 15253 10 5 5 CD cord-005453-4057qib7 15253 11 X x NN cord-005453-4057qib7 15253 12 10 10 CD cord-005453-4057qib7 15253 13 7 7 CD cord-005453-4057qib7 15253 14 CD3 CD3 NNS cord-005453-4057qib7 15253 15 + + CC cord-005453-4057qib7 15253 16 cells cell NNS cord-005453-4057qib7 15253 17 / / SYM cord-005453-4057qib7 15253 18 Kg Kg NNP cord-005453-4057qib7 15253 19 / / SYM cord-005453-4057qib7 15253 20 receptor receptor NN cord-005453-4057qib7 15253 21 ) ) -RRB- cord-005453-4057qib7 15253 22 was be VBD cord-005453-4057qib7 15253 23 performed perform VBN cord-005453-4057qib7 15253 24 and and CC cord-005453-4057qib7 15253 25 at at IN cord-005453-4057qib7 15253 26 this this DT cord-005453-4057qib7 15253 27 time time NN cord-005453-4057qib7 15253 28 the the DT cord-005453-4057qib7 15253 29 patient patient NN cord-005453-4057qib7 15253 30 is be VBZ cord-005453-4057qib7 15253 31 without without IN cord-005453-4057qib7 15253 32 clinical clinical JJ cord-005453-4057qib7 15253 33 manifestations manifestation NNS cord-005453-4057qib7 15253 34 of of IN cord-005453-4057qib7 15253 35 fMF fmf CD cord-005453-4057qib7 15253 36 or or CC cord-005453-4057qib7 15253 37 GVHD GVHD NNP cord-005453-4057qib7 15253 38 . . . cord-005453-4057qib7 15254 1 Conclusions conclusion NNS cord-005453-4057qib7 15254 2 : : : cord-005453-4057qib7 15255 1 the the DT cord-005453-4057qib7 15255 2 clinical clinical JJ cord-005453-4057qib7 15255 3 response response NN cord-005453-4057qib7 15255 4 of of IN cord-005453-4057qib7 15255 5 the the DT cord-005453-4057qib7 15255 6 presented present VBN cord-005453-4057qib7 15255 7 case case NN cord-005453-4057qib7 15255 8 confirms confirm VBZ cord-005453-4057qib7 15255 9 what what WP cord-005453-4057qib7 15255 10 has have VBZ cord-005453-4057qib7 15255 11 been be VBN cord-005453-4057qib7 15255 12 reported report VBN cord-005453-4057qib7 15255 13 in in IN cord-005453-4057qib7 15255 14 the the DT cord-005453-4057qib7 15255 15 literature literature NN cord-005453-4057qib7 15255 16 . . . cord-005453-4057qib7 15256 1 CTCLs CTCLs NNP cord-005453-4057qib7 15256 2 appear appear VBP cord-005453-4057qib7 15256 3 to to TO cord-005453-4057qib7 15256 4 be be VB cord-005453-4057qib7 15256 5 particularly particularly RB cord-005453-4057qib7 15256 6 susceptible susceptible JJ cord-005453-4057qib7 15256 7 to to IN cord-005453-4057qib7 15256 8 GVL GVL NNP cord-005453-4057qib7 15256 9 effect effect NN cord-005453-4057qib7 15256 10 , , , cord-005453-4057qib7 15256 11 which which WDT cord-005453-4057qib7 15256 12 makes make VBZ cord-005453-4057qib7 15256 13 HSCT HSCT NNP cord-005453-4057qib7 15256 14 a a DT cord-005453-4057qib7 15256 15 potential potential JJ cord-005453-4057qib7 15256 16 cure cure NN cord-005453-4057qib7 15256 17 for for IN cord-005453-4057qib7 15256 18 advanced advanced JJ cord-005453-4057qib7 15256 19 CTCLs ctcl NNS cord-005453-4057qib7 15256 20 in in IN cord-005453-4057qib7 15256 21 eligible eligible JJ cord-005453-4057qib7 15256 22 patients patient NNS cord-005453-4057qib7 15256 23 . . . cord-005453-4057qib7 15257 1 The the DT cord-005453-4057qib7 15257 2 timing timing NN cord-005453-4057qib7 15257 3 to to TO cord-005453-4057qib7 15257 4 perform perform VB cord-005453-4057qib7 15257 5 HSCT HSCT NNP cord-005453-4057qib7 15257 6 in in IN cord-005453-4057qib7 15257 7 the the DT cord-005453-4057qib7 15257 8 clinical clinical JJ cord-005453-4057qib7 15257 9 course course NN cord-005453-4057qib7 15257 10 of of IN cord-005453-4057qib7 15257 11 the the DT cord-005453-4057qib7 15257 12 disease disease NN cord-005453-4057qib7 15257 13 remains remain VBZ cord-005453-4057qib7 15257 14 a a DT cord-005453-4057qib7 15257 15 matter matter NN cord-005453-4057qib7 15257 16 to to TO cord-005453-4057qib7 15257 17 be be VB cord-005453-4057qib7 15257 18 settled settle VBN cord-005453-4057qib7 15257 19 Clinical Clinical NNP cord-005453-4057qib7 15257 20 Trial Trial NNP cord-005453-4057qib7 15257 21 Registry Registry NNP cord-005453-4057qib7 15257 22 : : : cord-005453-4057qib7 15257 23 not not RB cord-005453-4057qib7 15257 24 applicable applicable JJ cord-005453-4057qib7 15257 25 Disclosure disclosure NN cord-005453-4057qib7 15257 26 : : : cord-005453-4057qib7 15257 27 no no DT cord-005453-4057qib7 15257 28 conflict conflict NN cord-005453-4057qib7 15257 29 of of IN cord-005453-4057qib7 15257 30 interest interest NN cord-005453-4057qib7 15257 31 P755 P755 NNP cord-005453-4057qib7 15257 32 Abstract Abstract NNP cord-005453-4057qib7 15257 33 already already RB cord-005453-4057qib7 15257 34 published publish VBN cord-005453-4057qib7 15257 35 . . . cord-005453-4057qib7 15258 1 Methods method NNS cord-005453-4057qib7 15258 2 : : : cord-005453-4057qib7 15258 3 We -PRON- PRP cord-005453-4057qib7 15258 4 applied apply VBD cord-005453-4057qib7 15258 5 next next JJ cord-005453-4057qib7 15258 6 generation generation NN cord-005453-4057qib7 15258 7 sequencing sequencing NN cord-005453-4057qib7 15258 8 ( ( -LRB- cord-005453-4057qib7 15258 9 PGM PGM NNP cord-005453-4057qib7 15258 10 , , , cord-005453-4057qib7 15258 11 Ion Ion NNP cord-005453-4057qib7 15258 12 Torrent/ Torrent/ NNP cord-005453-4057qib7 15258 13 Fischer Fischer NNP cord-005453-4057qib7 15258 14 Lifetechnologies Lifetechnologies NNP cord-005453-4057qib7 15258 15 ) ) -RRB- cord-005453-4057qib7 15258 16 to to IN cord-005453-4057qib7 15258 17 an an DT cord-005453-4057qib7 15258 18 unselected unselected JJ cord-005453-4057qib7 15258 19 cohort cohort NN cord-005453-4057qib7 15258 20 of of IN cord-005453-4057qib7 15258 21 414 414 CD cord-005453-4057qib7 15258 22 patients patient NNS cord-005453-4057qib7 15258 23 ( ( -LRB- cord-005453-4057qib7 15258 24 176 176 CD cord-005453-4057qib7 15258 25 female female NN cord-005453-4057qib7 15258 26 , , , cord-005453-4057qib7 15258 27 238 238 CD cord-005453-4057qib7 15258 28 male male JJ cord-005453-4057qib7 15258 29 , , , cord-005453-4057qib7 15258 30 median median JJ cord-005453-4057qib7 15258 31 age age NN cord-005453-4057qib7 15258 32 59 59 CD cord-005453-4057qib7 15258 33 ( ( -LRB- cord-005453-4057qib7 15258 34 2 2 CD cord-005453-4057qib7 15258 35 - - SYM cord-005453-4057qib7 15258 36 80 80 CD cord-005453-4057qib7 15258 37 ) ) -RRB- cord-005453-4057qib7 15258 38 years year NNS cord-005453-4057qib7 15258 39 ) ) -RRB- cord-005453-4057qib7 15258 40 who who WP cord-005453-4057qib7 15258 41 had have VBD cord-005453-4057qib7 15258 42 been be VBN cord-005453-4057qib7 15258 43 referred refer VBN cord-005453-4057qib7 15258 44 for for IN cord-005453-4057qib7 15258 45 allogeneic allogeneic NN cord-005453-4057qib7 15258 46 stem stem NN cord-005453-4057qib7 15258 47 cell cell NN cord-005453-4057qib7 15258 48 transplantation transplantation NN cord-005453-4057qib7 15258 49 due due IN cord-005453-4057qib7 15258 50 to to IN cord-005453-4057qib7 15258 51 the the DT cord-005453-4057qib7 15258 52 presence presence NN cord-005453-4057qib7 15258 53 of of IN cord-005453-4057qib7 15258 54 a a DT cord-005453-4057qib7 15258 55 high high JJ cord-005453-4057qib7 15258 56 - - HYPH cord-005453-4057qib7 15258 57 risk risk NN cord-005453-4057qib7 15258 58 myeloid myeloid NN cord-005453-4057qib7 15258 59 disorder disorder NN cord-005453-4057qib7 15258 60 DNMT3A DNMT3A NNP cord-005453-4057qib7 15258 61 R882H R882H NNP cord-005453-4057qib7 15258 62 ( ( -LRB- cord-005453-4057qib7 15258 63 3.1 3.1 CD cord-005453-4057qib7 15258 64 % % NN cord-005453-4057qib7 15258 65 ) ) -RRB- cord-005453-4057qib7 15258 66 .98 .98 NFP cord-005453-4057qib7 15258 67 ) ) -RRB- cord-005453-4057qib7 15258 68 , , , cord-005453-4057qib7 15258 69 CEBPA CEBPA NNP cord-005453-4057qib7 15258 70 ( ( -LRB- cord-005453-4057qib7 15258 71 18.1 18.1 CD cord-005453-4057qib7 15258 72 % % NN cord-005453-4057qib7 15258 73 ; ; : cord-005453-4057qib7 15258 74 CEB CEB NNP cord-005453-4057qib7 15258 75 - - HYPH cord-005453-4057qib7 15258 76 PAP198S PAP198S NNP cord-005453-4057qib7 15258 77 ( ( -LRB- cord-005453-4057qib7 15258 78 16.9 16.9 CD cord-005453-4057qib7 15258 79 % % NN cord-005453-4057qib7 15258 80 ) ) -RRB- cord-005453-4057qib7 15258 81 VUS VUS NNP cord-005453-4057qib7 15258 82 ) ) -RRB- cord-005453-4057qib7 15258 83 KRAS KRAS NNP cord-005453-4057qib7 15258 84 ( ( -LRB- cord-005453-4057qib7 15258 85 6.5 6.5 CD cord-005453-4057qib7 15258 86 % % NN cord-005453-4057qib7 15258 87 ; ; : cord-005453-4057qib7 15258 88 KRASR161R KRASR161R NNP cord-005453-4057qib7 15258 89 ( ( -LRB- cord-005453-4057qib7 15258 90 3.1 3.1 CD cord-005453-4057qib7 15258 91 % % NN cord-005453-4057qib7 15258 92 ) ) -RRB- cord-005453-4057qib7 15258 93 VUS VUS NNP cord-005453-4057qib7 15258 94 ) ) -RRB- cord-005453-4057qib7 15258 95 , , , cord-005453-4057qib7 15258 96 and and CC cord-005453-4057qib7 15258 97 KIT kit NN cord-005453-4057qib7 15258 98 ( ( -LRB- cord-005453-4057qib7 15258 99 3.9 3.9 CD cord-005453-4057qib7 15258 100 % % NN cord-005453-4057qib7 15258 101 ; ; , cord-005453-4057qib7 15258 102 KITM541L kitm541l JJ cord-005453-4057qib7 15258 103 ( ( -LRB- cord-005453-4057qib7 15258 104 3.9 3.9 CD cord-005453-4057qib7 15258 105 % % NN cord-005453-4057qib7 15258 106 ) ) -RRB- cord-005453-4057qib7 15258 107 .74 .74 NFP cord-005453-4057qib7 15258 108 ) ) -RRB- cord-005453-4057qib7 15258 109 . . . cord-005453-4057qib7 15259 1 Patients patient NNS cord-005453-4057qib7 15259 2 displayed display VBD cord-005453-4057qib7 15259 3 a a DT cord-005453-4057qib7 15259 4 median median NN cord-005453-4057qib7 15259 5 of of IN cord-005453-4057qib7 15259 6 3 3 CD cord-005453-4057qib7 15259 7 sequence sequence NN cord-005453-4057qib7 15259 8 variants variant NNS cord-005453-4057qib7 15259 9 ( ( -LRB- cord-005453-4057qib7 15259 10 AML AML NNP cord-005453-4057qib7 15259 11 , , , cord-005453-4057qib7 15259 12 MPN MPN NNP cord-005453-4057qib7 15259 13 and and CC cord-005453-4057qib7 15259 14 CMML CMML NNP cord-005453-4057qib7 15259 15 patients patient NNS cord-005453-4057qib7 15259 16 each each DT cord-005453-4057qib7 15259 17 3 3 CD cord-005453-4057qib7 15259 18 ; ; : cord-005453-4057qib7 15259 19 MDS MDS NNP cord-005453-4057qib7 15259 20 , , , cord-005453-4057qib7 15259 21 SAA SAA NNP cord-005453-4057qib7 15259 22 and and CC cord-005453-4057qib7 15259 23 patients patient NNS cord-005453-4057qib7 15259 24 with with IN cord-005453-4057qib7 15259 25 other other JJ cord-005453-4057qib7 15259 26 , , , cord-005453-4057qib7 15259 27 non non JJ cord-005453-4057qib7 15259 28 - - JJ cord-005453-4057qib7 15259 29 malignant malignant JJ cord-005453-4057qib7 15259 30 hematologic hematologic JJ cord-005453-4057qib7 15259 31 diseases disease NNS cord-005453-4057qib7 15259 32 each each DT cord-005453-4057qib7 15259 33 4 4 CD cord-005453-4057qib7 15259 34 Sequence sequence NN cord-005453-4057qib7 15259 35 variants variant NNS cord-005453-4057qib7 15259 36 found find VBD cord-005453-4057qib7 15259 37 most most RBS cord-005453-4057qib7 15259 38 frequently frequently RB cord-005453-4057qib7 15259 39 in in IN cord-005453-4057qib7 15259 40 AML AML NNP cord-005453-4057qib7 15259 41 were be VBD cord-005453-4057qib7 15259 42 CEBPAP198S CEBPAP198S NNP cord-005453-4057qib7 15259 43 ( ( -LRB- cord-005453-4057qib7 15259 44 13.2 13.2 CD cord-005453-4057qib7 15259 45 % % NN cord-005453-4057qib7 15259 46 of of IN cord-005453-4057qib7 15259 47 all all DT cord-005453-4057qib7 15259 48 sequence sequence NN cord-005453-4057qib7 15259 49 variants variant NNS cord-005453-4057qib7 15259 50 in in IN cord-005453-4057qib7 15259 51 patients patient NNS cord-005453-4057qib7 15259 52 with with IN cord-005453-4057qib7 15259 53 AML AML NNP cord-005453-4057qib7 15259 54 , , , cord-005453-4057qib7 15259 55 p p NN cord-005453-4057qib7 15259 56 < < XX cord-005453-4057qib7 15260 1 10 10 CD cord-005453-4057qib7 15261 1 -3 -3 NNP cord-005453-4057qib7 15261 2 , , , cord-005453-4057qib7 15261 3 chi² chi² JJ cord-005453-4057qib7 15261 4 test test NN cord-005453-4057qib7 15261 5 ) ) -RRB- cord-005453-4057qib7 15262 1 In in IN cord-005453-4057qib7 15262 2 patients patient NNS cord-005453-4057qib7 15262 3 suffering suffer VBG cord-005453-4057qib7 15262 4 CMML CMML NNP cord-005453-4057qib7 15262 5 , , , cord-005453-4057qib7 15262 6 DNMT3AR882H DNMT3AR882H NNP cord-005453-4057qib7 15262 7 was be VBD cord-005453-4057qib7 15262 8 particularly particularly RB cord-005453-4057qib7 15262 9 frequent frequent JJ cord-005453-4057qib7 15262 10 ( ( -LRB- cord-005453-4057qib7 15262 11 4.8 4.8 CD cord-005453-4057qib7 15262 12 % % NN cord-005453-4057qib7 15262 13 of of IN cord-005453-4057qib7 15262 14 all all DT cord-005453-4057qib7 15262 15 sequence sequence NN cord-005453-4057qib7 15262 16 variants variant NNS cord-005453-4057qib7 15262 17 in in IN cord-005453-4057qib7 15262 18 CMML CMML NNP cord-005453-4057qib7 15262 19 , , , cord-005453-4057qib7 15262 20 p=.064 p=.064 NN cord-005453-4057qib7 15262 21 ) ) -RRB- cord-005453-4057qib7 15262 22 . . . cord-005453-4057qib7 15263 1 ASXL1E1102D ASXL1E1102D NNP cord-005453-4057qib7 15263 2 ( ( -LRB- cord-005453-4057qib7 15264 1 2.1 2.1 CD cord-005453-4057qib7 15264 2 % % NN cord-005453-4057qib7 15264 3 of of IN cord-005453-4057qib7 15264 4 all all DT cord-005453-4057qib7 15264 5 sequence sequence NN cord-005453-4057qib7 15264 6 variants variant NNS cord-005453-4057qib7 15264 7 in in IN cord-005453-4057qib7 15264 8 other other JJ cord-005453-4057qib7 15264 9 , , , cord-005453-4057qib7 15264 10 non non JJ cord-005453-4057qib7 15264 11 - - JJ cord-005453-4057qib7 15264 12 malignant malignant JJ cord-005453-4057qib7 15264 13 hematologic hematologic JJ cord-005453-4057qib7 15264 14 diseases disease NNS cord-005453-4057qib7 15264 15 , , , cord-005453-4057qib7 15264 16 p=.699 p=.699 NN cord-005453-4057qib7 15264 17 ) ) -RRB- cord-005453-4057qib7 15264 18 , , , cord-005453-4057qib7 15264 19 IDH2R140Q IDH2R140Q NNP cord-005453-4057qib7 15264 20 ( ( -LRB- cord-005453-4057qib7 15264 21 2.1 2.1 CD cord-005453-4057qib7 15264 22 % % NN cord-005453-4057qib7 15264 23 , , , cord-005453-4057qib7 15264 24 p=.677 p=.677 NNP cord-005453-4057qib7 15264 25 ) ) -RRB- cord-005453-4057qib7 15264 26 and and CC cord-005453-4057qib7 15264 27 KRASR161R krasr161r NN cord-005453-4057qib7 15264 28 ( ( -LRB- cord-005453-4057qib7 15264 29 4.2 4.2 CD cord-005453-4057qib7 15264 30 % % NN cord-005453-4057qib7 15264 31 , , , cord-005453-4057qib7 15264 32 p=.010 p=.010 NNP cord-005453-4057qib7 15264 33 ) ) -RRB- cord-005453-4057qib7 15264 34 were be VBD cord-005453-4057qib7 15264 35 frequent frequent JJ cord-005453-4057qib7 15264 36 in in IN cord-005453-4057qib7 15264 37 other other JJ cord-005453-4057qib7 15264 38 , , , cord-005453-4057qib7 15264 39 non non JJ cord-005453-4057qib7 15264 40 - - JJ cord-005453-4057qib7 15264 41 malignant malignant JJ cord-005453-4057qib7 15264 42 hematologic hematologic JJ cord-005453-4057qib7 15264 43 diseases disease NNS cord-005453-4057qib7 15264 44 . . . cord-005453-4057qib7 15265 1 In in IN cord-005453-4057qib7 15265 2 SAA SAA NNP cord-005453-4057qib7 15265 3 , , , cord-005453-4057qib7 15265 4 NRASG12D NRASG12D NNPS cord-005453-4057qib7 15265 5 ( ( -LRB- cord-005453-4057qib7 15265 6 4 4 CD cord-005453-4057qib7 15265 7 % % NN cord-005453-4057qib7 15265 8 of of IN cord-005453-4057qib7 15265 9 all all DT cord-005453-4057qib7 15265 10 sequence sequence NN cord-005453-4057qib7 15265 11 variants variant NNS cord-005453-4057qib7 15265 12 in in IN cord-005453-4057qib7 15265 13 SAA SAA NNP cord-005453-4057qib7 15265 14 patients patient NNS cord-005453-4057qib7 15265 15 ; ; , cord-005453-4057qib7 15265 16 p=.005 p=.005 NNS cord-005453-4057qib7 15265 17 ) ) -RRB- cord-005453-4057qib7 15265 18 was be VBD cord-005453-4057qib7 15265 19 frequently frequently RB cord-005453-4057qib7 15265 20 found find VBN cord-005453-4057qib7 15265 21 , , , cord-005453-4057qib7 15265 22 as as IN cord-005453-4057qib7 15265 23 were be VBD cord-005453-4057qib7 15265 24 DNMT3AK456fs DNMT3AK456fs NNP cord-005453-4057qib7 15265 25 * * NFP cord-005453-4057qib7 15265 26 ( ( -LRB- cord-005453-4057qib7 15265 27 8 8 CD cord-005453-4057qib7 15265 28 % % NN cord-005453-4057qib7 15265 29 , , , cord-005453-4057qib7 15265 30 p=.007 p=.007 JJ cord-005453-4057qib7 15265 31 ) ) -RRB- cord-005453-4057qib7 15265 32 , , . cord-005453-4057qib7 15266 1 TET2L1721W tet2l1721w LS cord-005453-4057qib7 15266 2 ( ( -LRB- cord-005453-4057qib7 15266 3 8 8 CD cord-005453-4057qib7 15266 4 % % NN cord-005453-4057qib7 15266 5 , , , cord-005453-4057qib7 15266 6 p=.080 p=.080 NNP cord-005453-4057qib7 15266 7 ) ) -RRB- cord-005453-4057qib7 15266 8 and and CC cord-005453-4057qib7 15266 9 TET2I1762V tet2i1762v LS cord-005453-4057qib7 15266 10 ( ( -LRB- cord-005453-4057qib7 15266 11 8 8 CD cord-005453-4057qib7 15266 12 % % NN cord-005453-4057qib7 15266 13 , , , cord-005453-4057qib7 15266 14 p=.001 p=.001 NNP cord-005453-4057qib7 15266 15 ) ) -RRB- cord-005453-4057qib7 15266 16 . . . cord-005453-4057qib7 15267 1 Conclusions conclusion NNS cord-005453-4057qib7 15267 2 : : : cord-005453-4057qib7 15268 1 Taken take VBN cord-005453-4057qib7 15268 2 together together RB cord-005453-4057qib7 15268 3 , , , cord-005453-4057qib7 15268 4 these these DT cord-005453-4057qib7 15268 5 data datum NNS cord-005453-4057qib7 15268 6 show show VBP cord-005453-4057qib7 15268 7 that that IN cord-005453-4057qib7 15268 8 VUS VUS NNP cord-005453-4057qib7 15268 9 occur occur VBP cord-005453-4057qib7 15268 10 with with IN cord-005453-4057qib7 15268 11 high high JJ cord-005453-4057qib7 15268 12 abundancy abundancy NN cord-005453-4057qib7 15268 13 in in IN cord-005453-4057qib7 15268 14 this this DT cord-005453-4057qib7 15268 15 high high JJ cord-005453-4057qib7 15268 16 - - HYPH cord-005453-4057qib7 15268 17 risk risk NN cord-005453-4057qib7 15268 18 cohort cohort NN cord-005453-4057qib7 15268 19 of of IN cord-005453-4057qib7 15268 20 patients patient NNS cord-005453-4057qib7 15268 21 , , , cord-005453-4057qib7 15268 22 and and CC cord-005453-4057qib7 15268 23 that that IN cord-005453-4057qib7 15268 24 they -PRON- PRP cord-005453-4057qib7 15268 25 differ differ VBP cord-005453-4057qib7 15268 26 in in IN cord-005453-4057qib7 15268 27 frequency frequency NN cord-005453-4057qib7 15268 28 between between IN cord-005453-4057qib7 15268 29 various various JJ cord-005453-4057qib7 15268 30 myeloid myeloid JJ cord-005453-4057qib7 15268 31 disorders disorder NNS cord-005453-4057qib7 15268 32 Methods method NNS cord-005453-4057qib7 15268 33 : : : cord-005453-4057qib7 15268 34 Retrospective retrospective JJ cord-005453-4057qib7 15268 35 analysis analysis NN cord-005453-4057qib7 15268 36 of of IN cord-005453-4057qib7 15268 37 patientswho patientswho NN cord-005453-4057qib7 15268 38 experienced experience VBD cord-005453-4057qib7 15268 39 either either CC cord-005453-4057qib7 15268 40 hematological hematological JJ cord-005453-4057qib7 15268 41 relapse relapse NN cord-005453-4057qib7 15268 42 or or CC cord-005453-4057qib7 15268 43 progressed progress VBD cord-005453-4057qib7 15268 44 to to IN cord-005453-4057qib7 15268 45 AML AML NNP cord-005453-4057qib7 15268 46 after after IN cord-005453-4057qib7 15268 47 allo allo NN cord-005453-4057qib7 15268 48 - - HYPH cord-005453-4057qib7 15268 49 HSCT HSCT NNP cord-005453-4057qib7 15268 50 and and CC cord-005453-4057qib7 15268 51 were be VBD cord-005453-4057qib7 15268 52 treated treat VBN cord-005453-4057qib7 15268 53 with with IN cord-005453-4057qib7 15268 54 azacitidine azacitidine NNP cord-005453-4057qib7 15268 55 for for IN cord-005453-4057qib7 15268 56 this this DT cord-005453-4057qib7 15268 57 indication indication NN cord-005453-4057qib7 15268 58 at at IN cord-005453-4057qib7 15268 59 7 7 CD cord-005453-4057qib7 15268 60 hematological hematological JJ cord-005453-4057qib7 15268 61 centers center NNS cord-005453-4057qib7 15268 62 in in IN cord-005453-4057qib7 15268 63 Poland Poland NNP cord-005453-4057qib7 15268 64 . . . cord-005453-4057qib7 15269 1 The the DT cord-005453-4057qib7 15269 2 primary primary JJ cord-005453-4057qib7 15269 3 end end NN cord-005453-4057qib7 15269 4 - - HYPH cord-005453-4057qib7 15269 5 point point NN cord-005453-4057qib7 15269 6 was be VBD cord-005453-4057qib7 15269 7 overall overall JJ cord-005453-4057qib7 15269 8 survival survival NN cord-005453-4057qib7 15269 9 ( ( -LRB- cord-005453-4057qib7 15269 10 OS OS NNP cord-005453-4057qib7 15269 11 ) ) -RRB- cord-005453-4057qib7 15269 12 , , , cord-005453-4057qib7 15269 13 the the DT cord-005453-4057qib7 15269 14 secondary secondary JJ cord-005453-4057qib7 15269 15 -response -response NN cord-005453-4057qib7 15269 16 rate rate NN cord-005453-4057qib7 15269 17 . . . cord-005453-4057qib7 15270 1 Results result NNS cord-005453-4057qib7 15270 2 : : : cord-005453-4057qib7 15270 3 36 36 CD cord-005453-4057qib7 15270 4 patients patient NNS cord-005453-4057qib7 15270 5 , , , cord-005453-4057qib7 15270 6 22 22 CD cord-005453-4057qib7 15270 7 males male NNS cord-005453-4057qib7 15270 8 ( ( -LRB- cord-005453-4057qib7 15270 9 61.1 61.1 CD cord-005453-4057qib7 15270 10 % % NN cord-005453-4057qib7 15270 11 ) ) -RRB- cord-005453-4057qib7 15270 12 , , , cord-005453-4057qib7 15270 13 median median JJ cord-005453-4057qib7 15270 14 age age NN cord-005453-4057qib7 15270 15 52 52 CD cord-005453-4057qib7 15271 1 ( ( -LRB- cord-005453-4057qib7 15271 2 range range NN cord-005453-4057qib7 15271 3 , , , cord-005453-4057qib7 15271 4 15 15 CD cord-005453-4057qib7 15271 5 - - SYM cord-005453-4057qib7 15271 6 66 66 CD cord-005453-4057qib7 15271 7 ) ) -RRB- cord-005453-4057qib7 15271 8 , , , cord-005453-4057qib7 15271 9 were be VBD cord-005453-4057qib7 15271 10 enrolled enrol VBN cord-005453-4057qib7 15271 11 . . . cord-005453-4057qib7 15272 1 The the DT cord-005453-4057qib7 15272 2 primary primary JJ cord-005453-4057qib7 15272 3 indication indication NN cord-005453-4057qib7 15272 4 for for IN cord-005453-4057qib7 15272 5 allo allo NN cord-005453-4057qib7 15272 6 - - HYPH cord-005453-4057qib7 15272 7 HSCT HSCT NNP cord-005453-4057qib7 15272 8 was be VBD cord-005453-4057qib7 15272 9 AML AML NNP cord-005453-4057qib7 15272 10 Median median JJ cord-005453-4057qib7 15272 11 time time NN cord-005453-4057qib7 15272 12 from from IN cord-005453-4057qib7 15272 13 allo-(95%CI allo-(95%ci NN cord-005453-4057qib7 15272 14 : : : cord-005453-4057qib7 15272 15 4.9 4.9 CD cord-005453-4057qib7 15272 16 - - SYM cord-005453-4057qib7 15272 17 11 11 CD cord-005453-4057qib7 15272 18 ) ) -RRB- cord-005453-4057qib7 15272 19 ; ; : cord-005453-4057qib7 15272 20 with with IN cord-005453-4057qib7 15272 21 2-year 2-year CD cord-005453-4057qib7 15272 22 OS os NN cord-005453-4057qib7 15272 23 of of IN cord-005453-4057qib7 15272 24 17.2 17.2 CD cord-005453-4057qib7 15272 25 % % NN cord-005453-4057qib7 15272 26 ( ( -LRB- cord-005453-4057qib7 15272 27 95%CI 95%ci CD cord-005453-4057qib7 15272 28 : : : cord-005453-4057qib7 15272 29 5.1 5.1 CD cord-005453-4057qib7 15272 30 - - HYPH cord-005453-4057qib7 15272 31 35.2 35.2 CD cord-005453-4057qib7 15272 32 ) ) -RRB- cord-005453-4057qib7 15272 33 . . . cord-005453-4057qib7 15273 1 For for IN cord-005453-4057qib7 15273 2 patients patient NNS cord-005453-4057qib7 15273 3 stratified stratify VBN cord-005453-4057qib7 15273 4 according accord VBG cord-005453-4057qib7 15273 5 to to IN cord-005453-4057qib7 15273 6 EBMT EBMT NNP cord-005453-4057qib7 15273 7 AZA AZA NNP cord-005453-4057qib7 15273 8 relapse relapse NN cord-005453-4057qib7 15274 1 prognostic prognostic JJ cord-005453-4057qib7 15274 2 score score NN cord-005453-4057qib7 15274 3 2-year 2-year CD cord-005453-4057qib7 15274 4 OS OS NNP cord-005453-4057qib7 15274 5 was be VBD cord-005453-4057qib7 15274 6 : : : cord-005453-4057qib7 15274 7 9 9 CD cord-005453-4057qib7 15274 8 Prophylaxis Prophylaxis NNP cord-005453-4057qib7 15274 9 of of IN cord-005453-4057qib7 15274 10 aGVHD aGVHD NNP cord-005453-4057qib7 15274 11 : : : cord-005453-4057qib7 15275 1 with with IN cord-005453-4057qib7 15275 2 ATG ATG NNP cord-005453-4057qib7 15275 3 -ATGAM -ATGAM . cord-005453-4057qib7 15276 1 60 60 CD cord-005453-4057qib7 15276 2 mg mg NN cord-005453-4057qib7 15277 1 /b.w.-39pts(36,8 /b.w.-39pts(36,8 : cord-005453-4057qib7 15277 2 % % NN cord-005453-4057qib7 15277 3 ) ) -RRB- cord-005453-4057qib7 15277 4 , , , cord-005453-4057qib7 15277 5 posttransplant posttransplant NNP cord-005453-4057qib7 15277 6 cyclophosphomide cyclophosphomide NNP cord-005453-4057qib7 15277 7 ( ( -LRB- cord-005453-4057qib7 15277 8 PTCy PTCy NNPS cord-005453-4057qib7 15278 1 ) ) -RRB- cord-005453-4057qib7 15278 2 50mg 50mg JJ cord-005453-4057qib7 15278 3 / / SYM cord-005453-4057qib7 15278 4 b.w b.w NNP cord-005453-4057qib7 15278 5 . . . cord-005453-4057qib7 15279 1 on on IN cord-005453-4057qib7 15279 2 D+3;D+4 d+3;d+4 NN cord-005453-4057qib7 15279 3 - - HYPH cord-005453-4057qib7 15279 4 67pts 67pts NN cord-005453-4057qib7 15279 5 ( ( -LRB- cord-005453-4057qib7 15279 6 63,2 63,2 CD cord-005453-4057qib7 15279 7 % % NN cord-005453-4057qib7 15279 8 ) ) -RRB- cord-005453-4057qib7 15280 1 Conclusions conclusion NNS cord-005453-4057qib7 15280 2 : : : cord-005453-4057qib7 15281 1 Unmanipulated Unmanipulated NNP cord-005453-4057qib7 15281 2 Haplo Haplo NNP cord-005453-4057qib7 15281 3 - - HYPH cord-005453-4057qib7 15281 4 HSCT HSCT NNP cord-005453-4057qib7 15281 5 in in IN cord-005453-4057qib7 15281 6 1 1 CD cord-005453-4057qib7 15281 7 st st NNP cord-005453-4057qib7 15281 8 -2 -2 NNP cord-005453-4057qib7 15281 9 nd nd NNP cord-005453-4057qib7 15281 10 CR CR NNP cord-005453-4057qib7 15281 11 in in IN cord-005453-4057qib7 15281 12 children child NNS cord-005453-4057qib7 15281 13 and and CC cord-005453-4057qib7 15281 14 adolescents adolescent NNS cord-005453-4057qib7 15281 15 with with IN cord-005453-4057qib7 15281 16 high high JJ cord-005453-4057qib7 15281 17 risk risk NN cord-005453-4057qib7 15282 1 AL AL NNP cord-005453-4057qib7 15282 2 allows allow VBZ cord-005453-4057qib7 15282 3 achieving achieve VBG cord-005453-4057qib7 15282 4 the the DT cord-005453-4057qib7 15282 5 long long JJ cord-005453-4057qib7 15282 6 - - HYPH cord-005453-4057qib7 15282 7 term term NN cord-005453-4057qib7 15282 8 survival survival NN cord-005453-4057qib7 15282 9 in in IN cord-005453-4057qib7 15282 10 64,7 64,7 CD cord-005453-4057qib7 15282 11 % % NN cord-005453-4057qib7 15282 12 . . . cord-005453-4057qib7 15283 1 The the DT cord-005453-4057qib7 15283 2 use use NN cord-005453-4057qib7 15283 3 of of IN cord-005453-4057qib7 15283 4 G G NNP cord-005453-4057qib7 15283 5 - - HYPH cord-005453-4057qib7 15283 6 CSF CSF NNP cord-005453-4057qib7 15283 7 stimulated stimulate VBD cord-005453-4057qib7 15284 1 unmanipulated unmanipulated JJ cord-005453-4057qib7 15284 2 Haplo Haplo NNP cord-005453-4057qib7 15284 3 - - HYPH cord-005453-4057qib7 15284 4 BM BM NNP cord-005453-4057qib7 15284 5 is be VBZ cord-005453-4057qib7 15284 6 associated associate VBN cord-005453-4057qib7 15284 7 with with IN cord-005453-4057qib7 15284 8 a a DT cord-005453-4057qib7 15284 9 satisfactory satisfactory JJ cord-005453-4057qib7 15284 10 rate rate NN cord-005453-4057qib7 15284 11 of of IN cord-005453-4057qib7 15284 12 engraftment engraftment NN cord-005453-4057qib7 15284 13 . . . cord-005453-4057qib7 15285 1 The the DT cord-005453-4057qib7 15285 2 main main JJ cord-005453-4057qib7 15285 3 cause cause NN cord-005453-4057qib7 15285 4 of of IN cord-005453-4057qib7 15285 5 death death NN cord-005453-4057qib7 15285 6 in in IN cord-005453-4057qib7 15285 7 our -PRON- PRP$ cord-005453-4057qib7 15285 8 study study NN cord-005453-4057qib7 15285 9 was be VBD cord-005453-4057qib7 15285 10 relapse relapse NN cord-005453-4057qib7 15285 11 after after IN cord-005453-4057qib7 15285 12 allo allo NN cord-005453-4057qib7 15285 13 - - HYPH cord-005453-4057qib7 15285 14 HSCT HSCT NNP cord-005453-4057qib7 15285 15 . . . cord-005453-4057qib7 15286 1 The the DT cord-005453-4057qib7 15286 2 frequency frequency NN cord-005453-4057qib7 15286 3 of of IN cord-005453-4057qib7 15286 4 acute acute JJ cord-005453-4057qib7 15286 5 and and CC cord-005453-4057qib7 15286 6 chronic chronic JJ cord-005453-4057qib7 15286 7 GVHD GVHD NNP cord-005453-4057qib7 15286 8 was be VBD cord-005453-4057qib7 15286 9 acceptable acceptable JJ cord-005453-4057qib7 15286 10 , , , cord-005453-4057qib7 15286 11 10-years 10-years CD cord-005453-4057qib7 15286 12 GRFS grfs NN cord-005453-4057qib7 15286 13 rate rate NN cord-005453-4057qib7 15286 14 of of IN cord-005453-4057qib7 15286 15 35,3 35,3 CD cord-005453-4057qib7 15286 16 % % NN cord-005453-4057qib7 15286 17 in in IN cord-005453-4057qib7 15286 18 1 1 CD cord-005453-4057qib7 15287 1 st st NNP cord-005453-4057qib7 15287 2 -2 -2 NNP cord-005453-4057qib7 15287 3 nd nd NNP cord-005453-4057qib7 15287 4 CR CR NNP cord-005453-4057qib7 15287 5 represents represent VBZ cord-005453-4057qib7 15287 6 good good JJ cord-005453-4057qib7 15287 7 quality quality NN cord-005453-4057qib7 15287 8 of of IN cord-005453-4057qib7 15287 9 life life NN cord-005453-4057qib7 15287 10 following follow VBG cord-005453-4057qib7 15287 11 unmanipulated unmanipulated JJ cord-005453-4057qib7 15287 12 Haplo Haplo NNP cord-005453-4057qib7 15287 13 - - HYPH cord-005453-4057qib7 15287 14 HSCT HSCT NNP cord-005453-4057qib7 15287 15 and and CC cord-005453-4057qib7 15287 16 therefore therefore RB cord-005453-4057qib7 15287 17 may may MD cord-005453-4057qib7 15287 18 be be VB cord-005453-4057qib7 15287 19 recommended recommend VBN cord-005453-4057qib7 15287 20 as as IN cord-005453-4057qib7 15287 21 option option NN cord-005453-4057qib7 15287 22 for for IN cord-005453-4057qib7 15287 23 use use NN cord-005453-4057qib7 15287 24 in in IN cord-005453-4057qib7 15287 25 children child NNS cord-005453-4057qib7 15287 26 and and CC cord-005453-4057qib7 15287 27 adolescents adolescent NNS cord-005453-4057qib7 15287 28 with with IN cord-005453-4057qib7 15287 29 high high JJ cord-005453-4057qib7 15287 30 - - HYPH cord-005453-4057qib7 15287 31 risk risk NN cord-005453-4057qib7 15287 32 AL AL NNP cord-005453-4057qib7 15287 33 . . . cord-005453-4057qib7 15288 1 Disclosure disclosure NN cord-005453-4057qib7 15288 2 : : : cord-005453-4057qib7 15288 3 Nothing nothing NN cord-005453-4057qib7 15288 4 to to TO cord-005453-4057qib7 15288 5 declare declare VB cord-005453-4057qib7 15288 6 Background background NN cord-005453-4057qib7 15288 7 : : : cord-005453-4057qib7 15288 8 B7-H3 B7-H3 NNP cord-005453-4057qib7 15289 1 ( ( -LRB- cord-005453-4057qib7 15289 2 CD276 CD276 NNP cord-005453-4057qib7 15289 3 ) ) -RRB- cord-005453-4057qib7 15289 4 is be VBZ cord-005453-4057qib7 15289 5 thought think VBN cord-005453-4057qib7 15289 6 to to TO cord-005453-4057qib7 15289 7 act act VB cord-005453-4057qib7 15289 8 as as IN cord-005453-4057qib7 15289 9 an an DT cord-005453-4057qib7 15289 10 immune immune JJ cord-005453-4057qib7 15289 11 checkpoint checkpoint NN cord-005453-4057qib7 15289 12 and and CC cord-005453-4057qib7 15289 13 regulates regulate VBZ cord-005453-4057qib7 15289 14 T T NNP cord-005453-4057qib7 15289 15 and and CC cord-005453-4057qib7 15289 16 NK NK NNP cord-005453-4057qib7 15289 17 cell cell NN cord-005453-4057qib7 15289 18 responses response NNS cord-005453-4057qib7 15289 19 . . . cord-005453-4057qib7 15290 1 It -PRON- PRP cord-005453-4057qib7 15290 2 is be VBZ cord-005453-4057qib7 15290 3 highly highly RB cord-005453-4057qib7 15290 4 overexpressed overexpresse VBN cord-005453-4057qib7 15290 5 on on IN cord-005453-4057qib7 15290 6 many many JJ cord-005453-4057qib7 15290 7 solid solid JJ cord-005453-4057qib7 15290 8 tumors tumor NNS cord-005453-4057qib7 15290 9 while while IN cord-005453-4057qib7 15290 10 on on IN cord-005453-4057qib7 15290 11 healthy healthy JJ cord-005453-4057qib7 15290 12 tissue tissue NN cord-005453-4057qib7 15290 13 protein protein NN cord-005453-4057qib7 15290 14 expression expression NN cord-005453-4057qib7 15290 15 is be VBZ cord-005453-4057qib7 15290 16 limited limit VBN cord-005453-4057qib7 15290 17 . . . cord-005453-4057qib7 15291 1 This this DT cord-005453-4057qib7 15291 2 makes make VBZ cord-005453-4057qib7 15291 3 B7-H3 B7-H3 NNP cord-005453-4057qib7 15291 4 an an DT cord-005453-4057qib7 15291 5 interesting interesting JJ cord-005453-4057qib7 15291 6 target target NN cord-005453-4057qib7 15291 7 for for IN cord-005453-4057qib7 15291 8 cancer cancer NN cord-005453-4057qib7 15291 9 immunotherapy immunotherapy NN cord-005453-4057qib7 15291 10 . . . cord-005453-4057qib7 15292 1 In in IN cord-005453-4057qib7 15292 2 highrisk highrisk JJ cord-005453-4057qib7 15292 3 neuroblastoma neuroblastoma NN cord-005453-4057qib7 15292 4 patients patient NNS cord-005453-4057qib7 15292 5 , , , cord-005453-4057qib7 15292 6 targeting target VBG cord-005453-4057qib7 15292 7 disialoganglioside disialoganglioside NNP cord-005453-4057qib7 15292 8 GD2 GD2 NNP cord-005453-4057qib7 15292 9 with with IN cord-005453-4057qib7 15292 10 the the DT cord-005453-4057qib7 15292 11 recently recently RB cord-005453-4057qib7 15292 12 approved approve VBN cord-005453-4057qib7 15292 13 monoclonal monoclonal JJ cord-005453-4057qib7 15292 14 antibody antibody NN cord-005453-4057qib7 15292 15 ( ( -LRB- cord-005453-4057qib7 15292 16 mAb mAb NNS cord-005453-4057qib7 15292 17 ) ) -RRB- cord-005453-4057qib7 15292 18 CH14.18 CH14.18 NNS cord-005453-4057qib7 15292 19 after after IN cord-005453-4057qib7 15292 20 autologous autologous JJ cord-005453-4057qib7 15292 21 or or CC cord-005453-4057qib7 15292 22 allogeneic allogeneic IN cord-005453-4057qib7 15292 23 SCT SCT NNP cord-005453-4057qib7 15292 24 , , , cord-005453-4057qib7 15292 25 significantly significantly RB cord-005453-4057qib7 15292 26 improves improve VBZ cord-005453-4057qib7 15292 27 survival survival NN cord-005453-4057qib7 15292 28 . . . cord-005453-4057qib7 15293 1 However however RB cord-005453-4057qib7 15293 2 , , , cord-005453-4057qib7 15293 3 GD2 GD2 NNP cord-005453-4057qib7 15293 4 expression expression NN cord-005453-4057qib7 15293 5 is be VBZ cord-005453-4057qib7 15293 6 heterogeneous heterogeneous JJ cord-005453-4057qib7 15293 7 and and CC cord-005453-4057qib7 15293 8 CH14.18 CH14.18 NNS cord-005453-4057qib7 15293 9 causes cause VBZ cord-005453-4057qib7 15293 10 severe severe JJ cord-005453-4057qib7 15293 11 adverse adverse JJ cord-005453-4057qib7 15293 12 effects effect NNS cord-005453-4057qib7 15293 13 . . . cord-005453-4057qib7 15294 1 Thus thus RB cord-005453-4057qib7 15294 2 , , , cord-005453-4057qib7 15294 3 we -PRON- PRP cord-005453-4057qib7 15294 4 evaluated evaluate VBD cord-005453-4057qib7 15294 5 B7-H3 B7-H3 NNP cord-005453-4057qib7 15294 6 as as IN cord-005453-4057qib7 15294 7 an an DT cord-005453-4057qib7 15294 8 alternative alternative JJ cord-005453-4057qib7 15294 9 or or CC cord-005453-4057qib7 15294 10 additional additional JJ cord-005453-4057qib7 15294 11 target target NN cord-005453-4057qib7 15294 12 antigen antigen NN cord-005453-4057qib7 15294 13 . . . cord-005453-4057qib7 15295 1 We -PRON- PRP cord-005453-4057qib7 15295 2 investigated investigate VBD cord-005453-4057qib7 15295 3 different different JJ cord-005453-4057qib7 15295 4 anti anti JJ cord-005453-4057qib7 15295 5 - - JJ cord-005453-4057qib7 15295 6 B7-H3 b7-h3 JJ cord-005453-4057qib7 15295 7 mAb mab NN cord-005453-4057qib7 15295 8 constructs construct NNS cord-005453-4057qib7 15295 9 and and CC cord-005453-4057qib7 15295 10 mAb mab NN cord-005453-4057qib7 15295 11 - - HYPH cord-005453-4057qib7 15295 12 cytokine cytokine NN cord-005453-4057qib7 15295 13 fusions fusion NNS cord-005453-4057qib7 15295 14 ( ( -LRB- cord-005453-4057qib7 15295 15 immunocytokines immunocytokines NNP cord-005453-4057qib7 15295 16 ) ) -RRB- cord-005453-4057qib7 15295 17 for for IN cord-005453-4057qib7 15295 18 their -PRON- PRP$ cord-005453-4057qib7 15295 19 ability ability NN cord-005453-4057qib7 15295 20 to to TO cord-005453-4057qib7 15295 21 elicit elicit VB cord-005453-4057qib7 15295 22 antibody antibody NN cord-005453-4057qib7 15295 23 - - HYPH cord-005453-4057qib7 15295 24 dependent dependent JJ cord-005453-4057qib7 15295 25 cellular cellular JJ cord-005453-4057qib7 15295 26 cytotoxicity cytotoxicity NN cord-005453-4057qib7 15295 27 ( ( -LRB- cord-005453-4057qib7 15295 28 ADCC ADCC NNP cord-005453-4057qib7 15295 29 ) ) -RRB- cord-005453-4057qib7 15295 30 Using use VBG cord-005453-4057qib7 15295 31 expanded expand VBN cord-005453-4057qib7 15295 32 γ γ NN cord-005453-4057qib7 15295 33 / / SYM cord-005453-4057qib7 15295 34 δ δ NN cord-005453-4057qib7 15295 35 T T NNP cord-005453-4057qib7 15295 36 cells cell NNS cord-005453-4057qib7 15295 37 of of IN cord-005453-4057qib7 15296 1 healthy healthy JJ cord-005453-4057qib7 15296 2 donors donor NNS cord-005453-4057qib7 15296 3 , , , cord-005453-4057qib7 15296 4 cHEX5LF cHEX5LF NNP cord-005453-4057qib7 15296 5 - - HYPH cord-005453-4057qib7 15296 6 IL2 IL2 NNP cord-005453-4057qib7 15296 7 was be VBD cord-005453-4057qib7 15296 8 confirmed confirm VBN cord-005453-4057qib7 15296 9 to to TO cord-005453-4057qib7 15296 10 be be VB cord-005453-4057qib7 15296 11 the the DT cord-005453-4057qib7 15296 12 most most RBS cord-005453-4057qib7 15296 13 effective effective JJ cord-005453-4057qib7 15296 14 mAb mab NN cord-005453-4057qib7 15296 15 construct construct NN cord-005453-4057qib7 15296 16 . . . cord-005453-4057qib7 15297 1 Interestingly interestingly RB cord-005453-4057qib7 15297 2 , , , cord-005453-4057qib7 15297 3 cHEK5-IL2 cHEK5-IL2 NNP cord-005453-4057qib7 15297 4 showed show VBD cord-005453-4057qib7 15297 5 comparable comparable JJ cord-005453-4057qib7 15297 6 target target NN cord-005453-4057qib7 15297 7 cell cell NN cord-005453-4057qib7 15297 8 lysis lysis NN cord-005453-4057qib7 15297 9 -however -however NN cord-005453-4057qib7 15297 10 , , , cord-005453-4057qib7 15297 11 lysis lysis NN cord-005453-4057qib7 15297 12 was be VBD cord-005453-4057qib7 15297 13 only only RB cord-005453-4057qib7 15297 14 transient transient JJ cord-005453-4057qib7 15297 15 while while IN cord-005453-4057qib7 15297 16 cHEX5LF cHEX5LF NNP cord-005453-4057qib7 15297 17 - - HYPH cord-005453-4057qib7 15297 18 IL2 IL2 NNP cord-005453-4057qib7 15297 19 mediated mediate VBD cord-005453-4057qib7 15297 20 permanent permanent JJ cord-005453-4057qib7 15297 21 target target NN cord-005453-4057qib7 15297 22 cell cell NN cord-005453-4057qib7 15297 23 lysis lysis NN cord-005453-4057qib7 15297 24 . . . cord-005453-4057qib7 15298 1 Using use VBG cord-005453-4057qib7 15298 2 patient patient JJ cord-005453-4057qib7 15298 3 PBMCs pbmc NNS cord-005453-4057qib7 15298 4 after after IN cord-005453-4057qib7 15298 5 receiving receive VBG cord-005453-4057qib7 15298 6 allogeneic allogeneic IN cord-005453-4057qib7 15298 7 SCT SCT NNP cord-005453-4057qib7 15298 8 , , , cord-005453-4057qib7 15298 9 cHEX5LF cHEX5LF NNP cord-005453-4057qib7 15298 10 - - HYPH cord-005453-4057qib7 15298 11 IL2 il2 NN cord-005453-4057qib7 15298 12 and and CC cord-005453-4057qib7 15298 13 CH14.18 CH14.18 NNP cord-005453-4057qib7 15298 14 mediated mediate VBD cord-005453-4057qib7 15298 15 comparable comparable JJ cord-005453-4057qib7 15298 16 lysis lysis NN cord-005453-4057qib7 15298 17 . . . cord-005453-4057qib7 15299 1 Calculated calculate VBN cord-005453-4057qib7 15299 2 specific specific JJ cord-005453-4057qib7 15299 3 lysis lysis NN cord-005453-4057qib7 15299 4 of of IN cord-005453-4057qib7 15299 5 LAN-1 LAN-1 NNP cord-005453-4057qib7 15299 6 ( ( -LRB- cord-005453-4057qib7 15299 7 after after IN cord-005453-4057qib7 15299 8 96 96 CD cord-005453-4057qib7 15299 9 hrs hrs NN cord-005453-4057qib7 15299 10 . . . cord-005453-4057qib7 15299 11 ; ; : cord-005453-4057qib7 15299 12 in in IN cord-005453-4057qib7 15299 13 ascending ascend VBG cord-005453-4057qib7 15299 14 order order NN cord-005453-4057qib7 15299 15 ) ) -RRB- cord-005453-4057qib7 15299 16 : : : cord-005453-4057qib7 15299 17 Targets target NNS cord-005453-4057qib7 15299 18 + + SYM cord-005453-4057qib7 15299 19 effectors effector NNS cord-005453-4057qib7 15299 20 w/o without IN cord-005453-4057qib7 15299 21 mAb mAb NNS cord-005453-4057qib7 15299 22 ( ( -LRB- cord-005453-4057qib7 15299 23 22 22 CD cord-005453-4057qib7 15299 24 % % NN cord-005453-4057qib7 15299 25 ) ) -RRB- cord-005453-4057qib7 15300 1 Conclusions conclusion NNS cord-005453-4057qib7 15300 2 : : : cord-005453-4057qib7 15300 3 B7-H3 B7-H3 NNP cord-005453-4057qib7 15300 4 is be VBZ cord-005453-4057qib7 15300 5 a a DT cord-005453-4057qib7 15300 6 suitable suitable JJ cord-005453-4057qib7 15300 7 target target NN cord-005453-4057qib7 15300 8 antigen antigen NN cord-005453-4057qib7 15300 9 in in IN cord-005453-4057qib7 15300 10 case case NN cord-005453-4057qib7 15301 1 GD2 GD2 NNP cord-005453-4057qib7 15301 2 expression expression NN cord-005453-4057qib7 15301 3 is be VBZ cord-005453-4057qib7 15301 4 low low JJ cord-005453-4057qib7 15301 5 or or CC cord-005453-4057qib7 15301 6 absent absent JJ cord-005453-4057qib7 15301 7 . . . cord-005453-4057qib7 15302 1 Immunocytokines Immunocytokines NNP cord-005453-4057qib7 15302 2 and and CC cord-005453-4057qib7 15302 3 Fcoptimized Fcoptimized NNP cord-005453-4057qib7 15302 4 mAbs mAbs NNP cord-005453-4057qib7 15302 5 targeting target VBG cord-005453-4057qib7 15302 6 B7-H3 B7-H3 NNP cord-005453-4057qib7 15302 7 might may MD cord-005453-4057qib7 15302 8 increase increase VB cord-005453-4057qib7 15302 9 the the DT cord-005453-4057qib7 15302 10 efficacy efficacy NN cord-005453-4057qib7 15302 11 of of IN cord-005453-4057qib7 15302 12 immunotherapy immunotherapy NN cord-005453-4057qib7 15302 13 in in IN cord-005453-4057qib7 15302 14 GD2-negative GD2-negative NNP cord-005453-4057qib7 15302 15 tumors tumor NNS cord-005453-4057qib7 15302 16 and and CC cord-005453-4057qib7 15302 17 in in IN cord-005453-4057qib7 15302 18 combinatory combinatory JJ cord-005453-4057qib7 15302 19 approaches approach NNS cord-005453-4057qib7 15302 20 . . . cord-005453-4057qib7 15303 1 Until until IN cord-005453-4057qib7 15303 2 now now RB cord-005453-4057qib7 15303 3 , , , cord-005453-4057qib7 15303 4 the the DT cord-005453-4057qib7 15303 5 low low JJ cord-005453-4057qib7 15303 6 - - HYPH cord-005453-4057qib7 15303 7 fucose fucose JJ cord-005453-4057qib7 15303 8 immunocytokine immunocytokine JJ cord-005453-4057qib7 15303 9 cHEX5LF cHEX5LF NNP cord-005453-4057qib7 15303 10 - - : cord-005453-4057qib7 15303 11 IL2 IL2 NNP cord-005453-4057qib7 15303 12 seems seem VBZ cord-005453-4057qib7 15303 13 to to TO cord-005453-4057qib7 15303 14 be be VB cord-005453-4057qib7 15303 15 the the DT cord-005453-4057qib7 15303 16 most most RBS cord-005453-4057qib7 15303 17 promising promising JJ cord-005453-4057qib7 15303 18 anti anti JJ cord-005453-4057qib7 15303 19 - - JJ cord-005453-4057qib7 15303 20 B7 B7 NNP cord-005453-4057qib7 15303 21 Great Great NNP cord-005453-4057qib7 15303 22 Ormond Ormond NNP cord-005453-4057qib7 15303 23 Street Street NNP cord-005453-4057qib7 15303 24 Hospital Hospital NNP cord-005453-4057qib7 15303 25 , , , cord-005453-4057qib7 15303 26 NHS NHS NNP cord-005453-4057qib7 15303 27 Foundation Foundation NNP cord-005453-4057qib7 15303 28 Trust Trust NNP cord-005453-4057qib7 15303 29 Petersburg/ Petersburg/ NNP cord-005453-4057qib7 15303 30 Raisa Raisa NNP cord-005453-4057qib7 15303 31 Gorbacheva Gorbacheva NNP cord-005453-4057qib7 15303 32 Memorial Memorial NNP cord-005453-4057qib7 15303 33 Institute Institute NNP cord-005453-4057qib7 15303 34 of of IN cord-005453-4057qib7 15303 35 Children Children NNP cord-005453-4057qib7 15303 36 's 's POS cord-005453-4057qib7 15303 37 Oncology Oncology NNP cord-005453-4057qib7 15303 38 , , , cord-005453-4057qib7 15303 39 Hematology Hematology NNP cord-005453-4057qib7 15303 40 and and CC cord-005453-4057qib7 15303 41 Transplantation Transplantation NNP cord-005453-4057qib7 15303 42 , , , cord-005453-4057qib7 15303 43 Rehabilitation Rehabilitation NNP cord-005453-4057qib7 15303 44 Medicine Medicine NNP cord-005453-4057qib7 15303 45 , , , cord-005453-4057qib7 15303 46 Saint Saint NNP cord-005453-4057qib7 15303 47 Petersburg Petersburg NNP cord-005453-4057qib7 15303 48 , , , cord-005453-4057qib7 15303 49 Russian Russian NNP cord-005453-4057qib7 15303 50 Federation Federation NNP cord-005453-4057qib7 15303 51 , , , cord-005453-4057qib7 15303 52 2 2 CD cord-005453-4057qib7 15303 53 First First NNP cord-005453-4057qib7 15303 54 I. I. NNP cord-005453-4057qib7 15303 55 Pavlov Pavlov NNP cord-005453-4057qib7 15303 56 State State NNP cord-005453-4057qib7 15303 57 Medical Medical NNP cord-005453-4057qib7 15303 58 University University NNP cord-005453-4057qib7 15303 59 of of IN cord-005453-4057qib7 15303 60 St. St. NNP cord-005453-4057qib7 15303 61 Petersburg Petersburg NNP cord-005453-4057qib7 15303 62 / / SYM cord-005453-4057qib7 15303 63 Raisa Raisa NNP cord-005453-4057qib7 15303 64 Gorbacheva Gorbacheva NNP cord-005453-4057qib7 15303 65 Memorial Memorial NNP cord-005453-4057qib7 15303 66 Institute Institute NNP cord-005453-4057qib7 15303 67 of of IN cord-005453-4057qib7 15303 68 Children Children NNP cord-005453-4057qib7 15303 69 's 's POS cord-005453-4057qib7 15303 70 Oncology Oncology NNP cord-005453-4057qib7 15303 71 , , , cord-005453-4057qib7 15303 72 Hematology Hematology NNP cord-005453-4057qib7 15303 73 and and CC cord-005453-4057qib7 15303 74 Transplantation Transplantation NNP cord-005453-4057qib7 15303 75 , , , cord-005453-4057qib7 15303 76 Bone Bone NNP cord-005453-4057qib7 15303 77 Marrow Marrow NNP cord-005453-4057qib7 15303 78 Transplantation transplantation NN cord-005453-4057qib7 15303 79 for for IN cord-005453-4057qib7 15303 80 Pediatric Pediatric NNP cord-005453-4057qib7 15303 81 Solid Solid NNP cord-005453-4057qib7 15303 82 Tumor Tumor NNP cord-005453-4057qib7 15303 83 Petersburg Petersburg NNP cord-005453-4057qib7 15303 84 / / SYM cord-005453-4057qib7 15303 85 Raisa Raisa NNP cord-005453-4057qib7 15303 86 Gorbacheva Gorbacheva NNP cord-005453-4057qib7 15303 87 Memorial Memorial NNP cord-005453-4057qib7 15303 88 Institute Institute NNP cord-005453-4057qib7 15303 89 of of IN cord-005453-4057qib7 15303 90 Children Children NNP cord-005453-4057qib7 15303 91 's 's POS cord-005453-4057qib7 15303 92 Oncology Oncology NNP cord-005453-4057qib7 15303 93 , , , cord-005453-4057qib7 15303 94 Hematology Hematology NNP cord-005453-4057qib7 15303 95 and and CC cord-005453-4057qib7 15303 96 Transplantation Transplantation NNP cord-005453-4057qib7 15303 97 , , , cord-005453-4057qib7 15303 98 Pediatric Pediatric NNP cord-005453-4057qib7 15303 99 HSCT HSCT NNP cord-005453-4057qib7 15303 100 Outpatients Outpatients NNP cord-005453-4057qib7 15303 101 , , , cord-005453-4057qib7 15303 102 Saint Saint NNP cord-005453-4057qib7 15303 103 Petersburg Petersburg NNP cord-005453-4057qib7 15303 104 , , , cord-005453-4057qib7 15303 105 Russian Russian NNP cord-005453-4057qib7 15303 106 Federation Federation NNP cord-005453-4057qib7 15303 107 1 1 CD cord-005453-4057qib7 15303 108 University University NNP cord-005453-4057qib7 15303 109 Hospital Hospital NNP cord-005453-4057qib7 15304 1 Carl Carl NNP cord-005453-4057qib7 15304 2 Gustav Gustav NNP cord-005453-4057qib7 15304 3 Carus Carus NNP cord-005453-4057qib7 15304 4 James`s james` VBD cord-005453-4057qib7 15304 5 Hospital Hospital NNP cord-005453-4057qib7 15304 6 Diagnosis Diagnosis NNP cord-005453-4057qib7 15304 7 was be VBD cord-005453-4057qib7 15304 8 AML AML NNP cord-005453-4057qib7 15304 9 in in IN cord-005453-4057qib7 15304 10 52 52 CD cord-005453-4057qib7 15304 11 % % NN cord-005453-4057qib7 15304 12 , , , cord-005453-4057qib7 15304 13 ALL all DT cord-005453-4057qib7 15304 14 in in IN cord-005453-4057qib7 15304 15 36 36 CD cord-005453-4057qib7 15304 16 % % NN cord-005453-4057qib7 15304 17 and and CC cord-005453-4057qib7 15304 18 MDS MDS NNP cord-005453-4057qib7 15304 19 in in IN cord-005453-4057qib7 15304 20 12 12 CD cord-005453-4057qib7 15304 21 % % NN cord-005453-4057qib7 15304 22 of of IN cord-005453-4057qib7 15304 23 patients patient NNS cord-005453-4057qib7 15304 24 . . . cord-005453-4057qib7 15305 1 90 90 CD cord-005453-4057qib7 15305 2 % % NN cord-005453-4057qib7 15305 3 of of IN cord-005453-4057qib7 15305 4 patients patient NNS cord-005453-4057qib7 15305 5 received receive VBD cord-005453-4057qib7 15305 6 PBSC PBSC NNP cord-005453-4057qib7 15305 7 grafts graft NNS cord-005453-4057qib7 15305 8 , , , cord-005453-4057qib7 15305 9 10 10 CD cord-005453-4057qib7 15305 10 % % NN cord-005453-4057qib7 15305 11 received receive VBD cord-005453-4057qib7 15305 12 unmanipulated unmanipulated JJ cord-005453-4057qib7 15305 13 bone bone NN cord-005453-4057qib7 15305 14 marrow marrow NN cord-005453-4057qib7 15305 15 grafts graft NNS cord-005453-4057qib7 15305 16 . . . cord-005453-4057qib7 15306 1 OS OS NNP cord-005453-4057qib7 15306 2 at at IN cord-005453-4057qib7 15306 3 2 2 CD cord-005453-4057qib7 15306 4 years year NNS cord-005453-4057qib7 15306 5 was be VBD cord-005453-4057qib7 15306 6 70 70 CD cord-005453-4057qib7 15306 7 % % NN cord-005453-4057qib7 15306 8 in in IN cord-005453-4057qib7 15306 9 MSD MSD NNP cord-005453-4057qib7 15306 10 / / SYM cord-005453-4057qib7 15306 11 MUD MUD NNP cord-005453-4057qib7 15306 12 - - HYPH cord-005453-4057qib7 15306 13 ATG ATG NNP cord-005453-4057qib7 15306 14 , , , cord-005453-4057qib7 15306 15 76 76 CD cord-005453-4057qib7 15306 16 % % NN cord-005453-4057qib7 15306 17 in in IN cord-005453-4057qib7 15306 18 haplo- haplo- NNP cord-005453-4057qib7 15307 1 ptCy ptcy RB cord-005453-4057qib7 15307 2 , , , cord-005453-4057qib7 15307 3 80 80 CD cord-005453-4057qib7 15307 4 % % NN cord-005453-4057qib7 15307 5 in in IN cord-005453-4057qib7 15307 6 MMUD MMUD NNP cord-005453-4057qib7 15307 7 - - : cord-005453-4057qib7 15307 8 ptCy ptcy NN cord-005453-4057qib7 15307 9 and and CC cord-005453-4057qib7 15307 10 43 43 CD cord-005453-4057qib7 15307 11 % % NN cord-005453-4057qib7 15307 12 in in IN cord-005453-4057qib7 15307 13 MMUD MMUD NNP cord-005453-4057qib7 15307 14 - - HYPH cord-005453-4057qib7 15307 15 ATG ATG NNP cord-005453-4057qib7 15307 16 groups group NNS cord-005453-4057qib7 15307 17 ( ( -LRB- cord-005453-4057qib7 15307 18 p=0.0027 p=0.0027 NNP cord-005453-4057qib7 15307 19 ) ) -RRB- cord-005453-4057qib7 15307 20 . . . cord-005453-4057qib7 15308 1 In in IN cord-005453-4057qib7 15308 2 a a DT cord-005453-4057qib7 15308 3 multivariate multivariate JJ cord-005453-4057qib7 15308 4 Cox Cox NNP cord-005453-4057qib7 15308 5 model model NN cord-005453-4057qib7 15308 6 Non non JJ cord-005453-4057qib7 15308 7 - - JJ cord-005453-4057qib7 15308 8 relapse relapse JJ cord-005453-4057qib7 15308 9 mortality mortality NN cord-005453-4057qib7 15308 10 was be VBD cord-005453-4057qib7 15308 11 17 17 CD cord-005453-4057qib7 15308 12 % % NN cord-005453-4057qib7 15308 13 , , , cord-005453-4057qib7 15308 14 17 17 CD cord-005453-4057qib7 15308 15 % % NN cord-005453-4057qib7 15308 16 , , , cord-005453-4057qib7 15308 17 4.5 4.5 CD cord-005453-4057qib7 15308 18 % % NN cord-005453-4057qib7 15308 19 and and CC cord-005453-4057qib7 15308 20 42 42 CD cord-005453-4057qib7 15308 21 % % NN cord-005453-4057qib7 15308 22 in in IN cord-005453-4057qib7 15308 23 MSD MSD NNP cord-005453-4057qib7 15308 24 / / SYM cord-005453-4057qib7 15308 25 MUD MUD NNP cord-005453-4057qib7 15308 26 - - HYPH cord-005453-4057qib7 15308 27 ATG ATG NNP cord-005453-4057qib7 15308 28 , , , cord-005453-4057qib7 15308 29 haplo haplo NN cord-005453-4057qib7 15308 30 - - HYPH cord-005453-4057qib7 15308 31 ptCy ptcy RB cord-005453-4057qib7 15308 32 , , , cord-005453-4057qib7 15309 1 MMUD MMUD NNP cord-005453-4057qib7 15309 2 - - : cord-005453-4057qib7 15309 3 ptCy ptcy NN cord-005453-4057qib7 15309 4 and and CC cord-005453-4057qib7 15309 5 MMUD MMUD NNP cord-005453-4057qib7 15309 6 - - HYPH cord-005453-4057qib7 15309 7 ATG ATG NNP cord-005453-4057qib7 15309 8 groups group NNS cord-005453-4057qib7 15309 9 , , , cord-005453-4057qib7 15309 10 respectively respectively RB cord-005453-4057qib7 15309 11 . . . cord-005453-4057qib7 15310 1 Cumulative cumulative JJ cord-005453-4057qib7 15310 2 incidence incidence NN cord-005453-4057qib7 15310 3 of of IN cord-005453-4057qib7 15310 4 acute acute JJ cord-005453-4057qib7 15310 5 GvHD gvhd NN cord-005453-4057qib7 15310 6 grade grade NN cord-005453-4057qib7 15310 7 3 3 CD cord-005453-4057qib7 15310 8 or or CC cord-005453-4057qib7 15310 9 4 4 CD cord-005453-4057qib7 15310 10 was be VBD cord-005453-4057qib7 15310 11 6 6 CD cord-005453-4057qib7 15310 12 % % NN cord-005453-4057qib7 15310 13 , , , cord-005453-4057qib7 15310 14 9.5 9.5 CD cord-005453-4057qib7 15310 15 % % NN cord-005453-4057qib7 15310 16 , , , cord-005453-4057qib7 15310 17 3 3 CD cord-005453-4057qib7 15310 18 % % NN cord-005453-4057qib7 15310 19 and and CC cord-005453-4057qib7 15310 20 12 12 CD cord-005453-4057qib7 15310 21 % % NN cord-005453-4057qib7 15310 22 after after IN cord-005453-4057qib7 15310 23 in in IN cord-005453-4057qib7 15310 24 MSD MSD NNP cord-005453-4057qib7 15310 25 / / SYM cord-005453-4057qib7 15310 26 MUD MUD NNP cord-005453-4057qib7 15310 27 - - HYPH cord-005453-4057qib7 15310 28 ATG ATG NNP cord-005453-4057qib7 15310 29 , , , cord-005453-4057qib7 15310 30 haplo- haplo- NN cord-005453-4057qib7 15311 1 ptCy ptcy DT cord-005453-4057qib7 15311 2 Cumulative cumulative JJ cord-005453-4057qib7 15311 3 incidence incidence NN cord-005453-4057qib7 15311 4 of of IN cord-005453-4057qib7 15311 5 chronic chronic JJ cord-005453-4057qib7 15311 6 GvHD gvhd NN cord-005453-4057qib7 15311 7 was be VBD cord-005453-4057qib7 15311 8 26 26 CD cord-005453-4057qib7 15311 9 % % NN cord-005453-4057qib7 15311 10 in in IN cord-005453-4057qib7 15311 11 the the DT cord-005453-4057qib7 15311 12 MSD MSD NNP cord-005453-4057qib7 15311 13 / / SYM cord-005453-4057qib7 15311 14 MUD MUD NNP cord-005453-4057qib7 15311 15 - - HYPH cord-005453-4057qib7 15311 16 ATG ATG NNP cord-005453-4057qib7 15311 17 group group NN cord-005453-4057qib7 15311 18 Uwe Uwe NNP cord-005453-4057qib7 15311 19 Platzbecker Platzbecker NNP cord-005453-4057qib7 15311 20 3 3 CD cord-005453-4057qib7 15311 21 , , , cord-005453-4057qib7 15312 1 Verena Verena NNP cord-005453-4057qib7 15312 2 Wais Wais NNP cord-005453-4057qib7 15312 3 4 4 CD cord-005453-4057qib7 15312 4 Republic Republic NNP cord-005453-4057qib7 15312 5 of of IN cord-005453-4057qib7 15312 6 China China NNP cord-005453-4057qib7 15312 7 Background Background NNP cord-005453-4057qib7 15312 8 : : : cord-005453-4057qib7 15312 9 There there EX cord-005453-4057qib7 15312 10 are be VBP cord-005453-4057qib7 15312 11 two two CD cord-005453-4057qib7 15312 12 most most RBS cord-005453-4057qib7 15312 13 noteworthy noteworthy JJ cord-005453-4057qib7 15312 14 strategies strategy NNS cord-005453-4057qib7 15312 15 of of IN cord-005453-4057qib7 15312 16 haploidentical haploidentical JJ cord-005453-4057qib7 15312 17 stem stem NN cord-005453-4057qib7 15312 18 cell cell NN cord-005453-4057qib7 15312 19 transplantations transplantation NNS cord-005453-4057qib7 15312 20 ( ( -LRB- cord-005453-4057qib7 15312 21 haplo haplo NNP cord-005453-4057qib7 15312 22 - - HYPH cord-005453-4057qib7 15312 23 HSCT HSCT NNP cord-005453-4057qib7 15312 24 ) ) -RRB- cord-005453-4057qib7 15312 25 , , , cord-005453-4057qib7 15312 26 the the DT cord-005453-4057qib7 15312 27 Baltimore Baltimore NNP cord-005453-4057qib7 15312 28 post post NN cord-005453-4057qib7 15312 29 - - NN cord-005453-4057qib7 15312 30 transplantation transplantation JJ cord-005453-4057qib7 15312 31 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 15312 32 ( ( -LRB- cord-005453-4057qib7 15312 33 PTCy PTCy NNP cord-005453-4057qib7 15312 34 ) ) -RRB- cord-005453-4057qib7 15312 35 with with IN cord-005453-4057qib7 15312 36 or or CC cord-005453-4057qib7 15312 37 without without IN cord-005453-4057qib7 15312 38 anti anti JJ cord-005453-4057qib7 15312 39 - - JJ cord-005453-4057qib7 15312 40 thymoglobulin thymoglobulin JJ cord-005453-4057qib7 15312 41 ( ( -LRB- cord-005453-4057qib7 15312 42 ATG ATG NNP cord-005453-4057qib7 15312 43 ) ) -RRB- cord-005453-4057qib7 15312 44 , , , cord-005453-4057qib7 15312 45 and and CC cord-005453-4057qib7 15312 46 the the DT cord-005453-4057qib7 15312 47 Beijing Beijing NNP cord-005453-4057qib7 15312 48 G G NNP cord-005453-4057qib7 15312 49 - - HYPH cord-005453-4057qib7 15312 50 CSF CSF NNP cord-005453-4057qib7 15312 51 primed prime VBN cord-005453-4057qib7 15312 52 bone bone NN cord-005453-4057qib7 15312 53 marrow marrow NN cord-005453-4057qib7 15312 54 ( ( -LRB- cord-005453-4057qib7 15312 55 BM BM NNP cord-005453-4057qib7 15312 56 ) ) -RRB- cord-005453-4057qib7 15312 57 plus plus CC cord-005453-4057qib7 15312 58 peripheral peripheral JJ cord-005453-4057qib7 15312 59 blood blood NN cord-005453-4057qib7 15312 60 stem stem NN cord-005453-4057qib7 15312 61 cells cell NNS cord-005453-4057qib7 15312 62 ( ( -LRB- cord-005453-4057qib7 15312 63 PBSC PBSC NNP cord-005453-4057qib7 15312 64 ) ) -RRB- cord-005453-4057qib7 15312 65 ( ( -LRB- cord-005453-4057qib7 15312 66 GIAC GIAC NNP cord-005453-4057qib7 15312 67 ) ) -RRB- cord-005453-4057qib7 15312 68 . . . cord-005453-4057qib7 15313 1 However however RB cord-005453-4057qib7 15313 2 , , , cord-005453-4057qib7 15313 3 the the DT cord-005453-4057qib7 15313 4 comparison comparison NN cord-005453-4057qib7 15313 5 of of IN cord-005453-4057qib7 15313 6 these these DT cord-005453-4057qib7 15313 7 two two CD cord-005453-4057qib7 15313 8 modalities modality NNS cord-005453-4057qib7 15313 9 is be VBZ cord-005453-4057qib7 15313 10 scarce scarce JJ cord-005453-4057qib7 15313 11 . . . cord-005453-4057qib7 15314 1 In in IN cord-005453-4057qib7 15314 2 this this DT cord-005453-4057qib7 15314 3 study study NN cord-005453-4057qib7 15314 4 , , , cord-005453-4057qib7 15314 5 we -PRON- PRP cord-005453-4057qib7 15314 6 aim aim VBP cord-005453-4057qib7 15314 7 to to TO cord-005453-4057qib7 15314 8 compare compare VB cord-005453-4057qib7 15314 9 these these DT cord-005453-4057qib7 15314 10 two two CD cord-005453-4057qib7 15314 11 approaches approach NNS cord-005453-4057qib7 15314 12 for for IN cord-005453-4057qib7 15314 13 hematological hematological JJ cord-005453-4057qib7 15314 14 malignancies malignancy NNS cord-005453-4057qib7 15314 15 based base VBN cord-005453-4057qib7 15314 16 on on IN cord-005453-4057qib7 15314 17 the the DT cord-005453-4057qib7 15314 18 Taiwan Taiwan NNP cord-005453-4057qib7 15314 19 Blood Blood NNP cord-005453-4057qib7 15314 20 and and CC cord-005453-4057qib7 15314 21 Marrow Marrow NNP cord-005453-4057qib7 15314 22 Transplantation transplantation NN cord-005453-4057qib7 15314 23 Registry registry NN cord-005453-4057qib7 15314 24 ( ( -LRB- cord-005453-4057qib7 15314 25 TBMTR TBMTR NNP cord-005453-4057qib7 15314 26 ) ) -RRB- cord-005453-4057qib7 15315 1 With with IN cord-005453-4057qib7 15315 2 the the DT cord-005453-4057qib7 15315 3 comparable comparable JJ cord-005453-4057qib7 15315 4 CD34 CD34 NNP cord-005453-4057qib7 15315 5 infusion infusion NN cord-005453-4057qib7 15315 6 amounts amount NNS cord-005453-4057qib7 15315 7 , , , cord-005453-4057qib7 15315 8 the the DT cord-005453-4057qib7 15315 9 neutrophil neutrophil NN cord-005453-4057qib7 15315 10 engraftment engraftment NN cord-005453-4057qib7 15315 11 time time NN cord-005453-4057qib7 15315 12 were be VBD cord-005453-4057qib7 15315 13 statistically statistically RB cord-005453-4057qib7 15315 14 distinct distinct JJ cord-005453-4057qib7 15315 15 among among IN cord-005453-4057qib7 15315 16 these these DT cord-005453-4057qib7 15315 17 three three CD cord-005453-4057qib7 15315 18 groups group NNS cord-005453-4057qib7 15315 19 [ [ -LRB- cord-005453-4057qib7 15315 20 D+12 D+12 NNP cord-005453-4057qib7 15315 21 ( ( -LRB- cord-005453-4057qib7 15315 22 group group NN cord-005453-4057qib7 15315 23 1 1 CD cord-005453-4057qib7 15315 24 ) ) -RRB- cord-005453-4057qib7 15315 25 vs. vs. FW cord-005453-4057qib7 15315 26 D+15 D+15 NNP cord-005453-4057qib7 15315 27 ( ( -LRB- cord-005453-4057qib7 15315 28 group group NN cord-005453-4057qib7 15315 29 2 2 CD cord-005453-4057qib7 15315 30 ) ) -RRB- cord-005453-4057qib7 15315 31 vs. vs. FW cord-005453-4057qib7 15315 32 D+17 D+17 NNP cord-005453-4057qib7 15315 33 ( ( -LRB- cord-005453-4057qib7 15315 34 group group NN cord-005453-4057qib7 15315 35 3 3 CD cord-005453-4057qib7 15315 36 ) ) -RRB- cord-005453-4057qib7 15315 37 , , , cord-005453-4057qib7 15315 38 respectively respectively RB cord-005453-4057qib7 15316 1 As as IN cord-005453-4057qib7 15316 2 to to IN cord-005453-4057qib7 15316 3 the the DT cord-005453-4057qib7 15316 4 graft graft NN cord-005453-4057qib7 15316 5 - - HYPH cord-005453-4057qib7 15316 6 versus versus IN cord-005453-4057qib7 15316 7 - - HYPH cord-005453-4057qib7 15316 8 host host NN cord-005453-4057qib7 15316 9 disease disease NN cord-005453-4057qib7 15316 10 ( ( -LRB- cord-005453-4057qib7 15316 11 GvHD GvHD NNP cord-005453-4057qib7 15316 12 ) ) -RRB- cord-005453-4057qib7 15316 13 , , , cord-005453-4057qib7 15316 14 the the DT cord-005453-4057qib7 15316 15 patients patient NNS cord-005453-4057qib7 15316 16 in in IN cord-005453-4057qib7 15316 17 group group NN cord-005453-4057qib7 15316 18 1 1 CD cord-005453-4057qib7 15316 19 had have VBD cord-005453-4057qib7 15316 20 more more JJR cord-005453-4057qib7 15316 21 grade grade NN cord-005453-4057qib7 15316 22 II II NNP cord-005453-4057qib7 15316 23 - - HYPH cord-005453-4057qib7 15316 24 IV IV NNP cord-005453-4057qib7 15316 25 but but CC cord-005453-4057qib7 15316 26 similar similar JJ cord-005453-4057qib7 15316 27 grade grade NN cord-005453-4057qib7 15316 28 III III NNP cord-005453-4057qib7 15316 29 - - HYPH cord-005453-4057qib7 15316 30 IV IV NNP cord-005453-4057qib7 15316 31 acute acute JJ cord-005453-4057qib7 15316 32 GvHD gvhd NN cord-005453-4057qib7 15316 33 compared compare VBN cord-005453-4057qib7 15316 34 with with IN cord-005453-4057qib7 15316 35 others other NNS cord-005453-4057qib7 15316 36 ( ( -LRB- cord-005453-4057qib7 15316 37 grade grade NN cord-005453-4057qib7 15316 38 II II NNP cord-005453-4057qib7 15316 39 - - HYPH cord-005453-4057qib7 15316 40 IV IV NNP cord-005453-4057qib7 15316 41 : : : cord-005453-4057qib7 15316 42 60.0 60.0 CD cord-005453-4057qib7 15316 43 % % NN cord-005453-4057qib7 15316 44 vs. vs. CC cord-005453-4057qib7 15316 45 37.5 37.5 CD cord-005453-4057qib7 15316 46 % % NN cord-005453-4057qib7 15316 47 vs. vs. CC cord-005453-4057qib7 15316 48 21.6 21.6 CD cord-005453-4057qib7 15316 49 % % NN cord-005453-4057qib7 15316 50 , , , cord-005453-4057qib7 15316 51 respectively respectively RB cord-005453-4057qib7 15316 52 Conclusions conclusion NNS cord-005453-4057qib7 15316 53 : : : cord-005453-4057qib7 15317 1 Haplo Haplo NNP cord-005453-4057qib7 15317 2 - - HYPH cord-005453-4057qib7 15317 3 HSCT HSCT NNP cord-005453-4057qib7 15317 4 with with IN cord-005453-4057qib7 15317 5 different different JJ cord-005453-4057qib7 15317 6 strategies strategy NNS cord-005453-4057qib7 15317 7 is be VBZ cord-005453-4057qib7 15317 8 a a DT cord-005453-4057qib7 15317 9 feasible feasible JJ cord-005453-4057qib7 15317 10 treatment treatment NN cord-005453-4057qib7 15317 11 modality modality NN cord-005453-4057qib7 15317 12 for for IN cord-005453-4057qib7 15317 13 hematologic hematologic JJ cord-005453-4057qib7 15317 14 malignancies malignancy NNS cord-005453-4057qib7 15317 15 in in IN cord-005453-4057qib7 15317 16 Taiwan Taiwan NNP cord-005453-4057qib7 15317 17 . . . cord-005453-4057qib7 15318 1 Regarding regard VBG cord-005453-4057qib7 15318 2 the the DT cord-005453-4057qib7 15318 3 retrospective retrospective JJ cord-005453-4057qib7 15318 4 nature nature NN cord-005453-4057qib7 15318 5 and and CC cord-005453-4057qib7 15318 6 limited limited JJ cord-005453-4057qib7 15318 7 patient patient JJ cord-005453-4057qib7 15318 8 numbers number NNS cord-005453-4057qib7 15318 9 of of IN cord-005453-4057qib7 15318 10 this this DT cord-005453-4057qib7 15318 11 study study NN cord-005453-4057qib7 15318 12 Republic Republic NNP cord-005453-4057qib7 15318 13 of of IN cord-005453-4057qib7 15318 14 China China NNP cord-005453-4057qib7 15318 15 Background Background NNP cord-005453-4057qib7 15318 16 : : : cord-005453-4057qib7 15318 17 We -PRON- PRP cord-005453-4057qib7 15318 18 previously previously RB cord-005453-4057qib7 15318 19 presented present VBD cord-005453-4057qib7 15318 20 a a DT cord-005453-4057qib7 15318 21 low low JJ cord-005453-4057qib7 15318 22 - - HYPH cord-005453-4057qib7 15318 23 resolution resolution NN cord-005453-4057qib7 15318 24 HLA HLA NNP cord-005453-4057qib7 15318 25 analysis analysis NN cord-005453-4057qib7 15318 26 of of IN cord-005453-4057qib7 15318 27 CEDACE CEDACE NNP cord-005453-4057qib7 15318 28 , , , cord-005453-4057qib7 15318 29 the the DT cord-005453-4057qib7 15318 30 voluntary voluntary JJ cord-005453-4057qib7 15318 31 Portuguese portuguese JJ cord-005453-4057qib7 15318 32 Bone Bone NNP cord-005453-4057qib7 15318 33 Marrow Marrow NNP cord-005453-4057qib7 15318 34 Donor Donor NNP cord-005453-4057qib7 15318 35 Registry Registry NNP cord-005453-4057qib7 15318 36 ( ( -LRB- cord-005453-4057qib7 15318 37 EBMT EBMT NNP cord-005453-4057qib7 15318 38 2011 2011 CD cord-005453-4057qib7 15318 39 , , , cord-005453-4057qib7 15318 40 Poster poster NN cord-005453-4057qib7 15318 41 P1127 P1127 NNP cord-005453-4057qib7 15318 42 ) ) -RRB- cord-005453-4057qib7 15318 43 and and CC cord-005453-4057qib7 15318 44 , , , cord-005453-4057qib7 15318 45 more more RBR cord-005453-4057qib7 15318 46 recently recently RB cord-005453-4057qib7 15318 47 , , , cord-005453-4057qib7 15318 48 its -PRON- PRP$ cord-005453-4057qib7 15318 49 epidemiological epidemiological JJ cord-005453-4057qib7 15318 50 characterization characterization NN cord-005453-4057qib7 15318 51 ( ( -LRB- cord-005453-4057qib7 15318 52 EBMT EBMT NNP cord-005453-4057qib7 15318 53 2018 2018 CD cord-005453-4057qib7 15318 54 , , , cord-005453-4057qib7 15318 55 Poster Poster NNP cord-005453-4057qib7 15318 56 B348 B348 NNP cord-005453-4057qib7 15318 57 ) ) -RRB- cord-005453-4057qib7 15318 58 . . . cord-005453-4057qib7 15319 1 Currently currently RB cord-005453-4057qib7 15319 2 , , , cord-005453-4057qib7 15319 3 CEDACE CEDACE NNP cord-005453-4057qib7 15319 4 is be VBZ cord-005453-4057qib7 15319 5 one one CD cord-005453-4057qib7 15319 6 of of IN cord-005453-4057qib7 15319 7 the the DT cord-005453-4057qib7 15319 8 largest large JJS cord-005453-4057qib7 15319 9 bone bone NN cord-005453-4057qib7 15319 10 marrow marrow NN cord-005453-4057qib7 15319 11 donor donor NN cord-005453-4057qib7 15319 12 registries registry NNS cord-005453-4057qib7 15319 13 in in IN cord-005453-4057qib7 15319 14 the the DT cord-005453-4057qib7 15319 15 world world NN cord-005453-4057qib7 15319 16 , , , cord-005453-4057qib7 15319 17 including include VBG cord-005453-4057qib7 15319 18 nearly nearly RB cord-005453-4057qib7 15319 19 4 4 CD cord-005453-4057qib7 15319 20 % % NN cord-005453-4057qib7 15319 21 of of IN cord-005453-4057qib7 15319 22 the the DT cord-005453-4057qib7 15319 23 country country NN cord-005453-4057qib7 15319 24 's 's POS cord-005453-4057qib7 15319 25 population population NN cord-005453-4057qib7 15319 26 , , , cord-005453-4057qib7 15319 27 twice twice PDT cord-005453-4057qib7 15319 28 the the DT cord-005453-4057qib7 15319 29 number number NN cord-005453-4057qib7 15319 30 of of IN cord-005453-4057qib7 15319 31 donors donor NNS cord-005453-4057qib7 15319 32 present present JJ cord-005453-4057qib7 15319 33 in in IN cord-005453-4057qib7 15319 34 2011 2011 CD cord-005453-4057qib7 15319 35 . . . cord-005453-4057qib7 15320 1 The the DT cord-005453-4057qib7 15320 2 current current JJ cord-005453-4057qib7 15320 3 work work NN cord-005453-4057qib7 15320 4 is be VBZ cord-005453-4057qib7 15320 5 an an DT cord-005453-4057qib7 15320 6 update update NN cord-005453-4057qib7 15320 7 on on IN cord-005453-4057qib7 15320 8 the the DT cord-005453-4057qib7 15320 9 most most RBS cord-005453-4057qib7 15320 10 common common JJ cord-005453-4057qib7 15320 11 HLA HLA NNP cord-005453-4057qib7 15320 12 haplotypes haplotype NNS cord-005453-4057qib7 15320 13 found find VBN cord-005453-4057qib7 15320 14 in in IN cord-005453-4057qib7 15320 15 CEDACE CEDACE NNP cord-005453-4057qib7 15320 16 Results Results NNPS cord-005453-4057qib7 15320 17 : : : cord-005453-4057qib7 15320 18 Of of IN cord-005453-4057qib7 15320 19 the the DT cord-005453-4057qib7 15320 20 396545 396545 CD cord-005453-4057qib7 15320 21 donors donor NNS cord-005453-4057qib7 15320 22 in in IN cord-005453-4057qib7 15320 23 the the DT cord-005453-4057qib7 15320 24 CEDACE CEDACE NNP cord-005453-4057qib7 15320 25 registry registry NN cord-005453-4057qib7 15320 26 , , , cord-005453-4057qib7 15320 27 99.51 99.51 CD cord-005453-4057qib7 15320 28 % % NN cord-005453-4057qib7 15320 29 were be VBD cord-005453-4057qib7 15320 30 typed type VBN cord-005453-4057qib7 15320 31 in in IN cord-005453-4057qib7 15320 32 at at RB cord-005453-4057qib7 15320 33 least least JJS cord-005453-4057qib7 15320 34 3 3 CD cord-005453-4057qib7 15320 35 loci locus NNS cord-005453-4057qib7 15320 36 ( ( -LRB- cord-005453-4057qib7 15320 37 HLA HLA NNP cord-005453-4057qib7 15320 38 - - HYPH cord-005453-4057qib7 15320 39 A/-B/-DRB1 A/-B/-DRB1 NNP cord-005453-4057qib7 15320 40 ) ) -RRB- cord-005453-4057qib7 15320 41 , , , cord-005453-4057qib7 15320 42 43.91 43.91 CD cord-005453-4057qib7 15320 43 % % NN cord-005453-4057qib7 15320 44 in in IN cord-005453-4057qib7 15320 45 4 4 CD cord-005453-4057qib7 15320 46 ( ( -LRB- cord-005453-4057qib7 15320 47 including include VBG cord-005453-4057qib7 15320 48 HLA HLA NNP cord-005453-4057qib7 15320 49 - - HYPH cord-005453-4057qib7 15320 50 Cw Cw NNP cord-005453-4057qib7 15320 51 ) ) -RRB- cord-005453-4057qib7 15320 52 , , , cord-005453-4057qib7 15320 53 and and CC cord-005453-4057qib7 15320 54 1.28 1.28 CD cord-005453-4057qib7 15320 55 % % NN cord-005453-4057qib7 15320 56 in in IN cord-005453-4057qib7 15320 57 5 5 CD cord-005453-4057qib7 15320 58 ( ( -LRB- cord-005453-4057qib7 15320 59 including include VBG cord-005453-4057qib7 15320 60 HLA HLA NNP cord-005453-4057qib7 15320 61 - - HYPH cord-005453-4057qib7 15320 62 DQB1)the DQB1)the NNP cord-005453-4057qib7 15320 63 5 5 CD cord-005453-4057qib7 15320 64 , , , cord-005453-4057qib7 15320 65 25 25 CD cord-005453-4057qib7 15320 66 and and CC cord-005453-4057qib7 15320 67 150 150 CD cord-005453-4057qib7 15320 68 most most RBS cord-005453-4057qib7 15320 69 common common JJ cord-005453-4057qib7 15320 70 haplotypes haplotype NNS cord-005453-4057qib7 15320 71 accounted account VBD cord-005453-4057qib7 15320 72 for for IN cord-005453-4057qib7 15320 73 , , , cord-005453-4057qib7 15320 74 respectively respectively RB cord-005453-4057qib7 15320 75 , , , cord-005453-4057qib7 15320 76 8.9 8.9 CD cord-005453-4057qib7 15320 77 % % NN cord-005453-4057qib7 15320 78 , , , cord-005453-4057qib7 15320 79 23.5 23.5 CD cord-005453-4057qib7 15320 80 % % NN cord-005453-4057qib7 15320 81 and and CC cord-005453-4057qib7 15320 82 50 50 CD cord-005453-4057qib7 15320 83 % % NN cord-005453-4057qib7 15320 84 of of IN cord-005453-4057qib7 15320 85 the the DT cord-005453-4057qib7 15320 86 haplotypes haplotype NNS cord-005453-4057qib7 15320 87 found find VBN cord-005453-4057qib7 15320 88 in in IN cord-005453-4057qib7 15320 89 the the DT cord-005453-4057qib7 15320 90 entire entire JJ cord-005453-4057qib7 15320 91 registry registry NN cord-005453-4057qib7 15320 92 . . . cord-005453-4057qib7 15321 1 The the DT cord-005453-4057qib7 15321 2 five five CD cord-005453-4057qib7 15321 3 most most RBS cord-005453-4057qib7 15321 4 common common JJ cord-005453-4057qib7 15321 5 haplotypes haplotype NNS cord-005453-4057qib7 15321 6 at at IN cord-005453-4057qib7 15321 7 the the DT cord-005453-4057qib7 15321 8 low low JJ cord-005453-4057qib7 15321 9 - - HYPH cord-005453-4057qib7 15321 10 resolution resolution NN cord-005453-4057qib7 15321 11 At at IN cord-005453-4057qib7 15321 12 the the DT cord-005453-4057qib7 15321 13 3 3 CD cord-005453-4057qib7 15321 14 loci locus NNS cord-005453-4057qib7 15321 15 , , , cord-005453-4057qib7 15321 16 low low JJ cord-005453-4057qib7 15321 17 - - HYPH cord-005453-4057qib7 15321 18 resolution resolution NN cord-005453-4057qib7 15321 19 level level NN cord-005453-4057qib7 15321 20 , , , cord-005453-4057qib7 15321 21 out out IN cord-005453-4057qib7 15321 22 of of IN cord-005453-4057qib7 15321 23 394621 394621 CD cord-005453-4057qib7 15321 24 donors donor NNS cord-005453-4057qib7 15321 25 , , , cord-005453-4057qib7 15321 26 167505 167505 CD cord-005453-4057qib7 15321 27 individual individual JJ cord-005453-4057qib7 15321 28 genotypes genotype NNS cord-005453-4057qib7 15321 29 were be VBD cord-005453-4057qib7 15321 30 identified identify VBN cord-005453-4057qib7 15321 31 , , , cord-005453-4057qib7 15321 32 leading lead VBG cord-005453-4057qib7 15321 33 to to IN cord-005453-4057qib7 15321 34 an an DT cord-005453-4057qib7 15321 35 HLA HLA NNP cord-005453-4057qib7 15321 36 matching matching NN cord-005453-4057qib7 15321 37 probability probability NN cord-005453-4057qib7 15321 38 at at IN cord-005453-4057qib7 15321 39 this this DT cord-005453-4057qib7 15321 40 level level NN cord-005453-4057qib7 15321 41 of of IN cord-005453-4057qib7 15321 42 57.6 57.6 CD cord-005453-4057qib7 15321 43 % % NN cord-005453-4057qib7 15321 44 HID HID NNP cord-005453-4057qib7 15321 45 - - HYPH cord-005453-4057qib7 15321 46 HSCT HSCT NNP cord-005453-4057qib7 15321 47 ) ) -RRB- cord-005453-4057qib7 15321 48 have have VBP cord-005453-4057qib7 15321 49 a a DT cord-005453-4057qib7 15321 50 stronger strong JJR cord-005453-4057qib7 15321 51 anti anti JJ cord-005453-4057qib7 15321 52 - - JJ cord-005453-4057qib7 15321 53 leukemia leukemia JJ cord-005453-4057qib7 15321 54 effect effect NN cord-005453-4057qib7 15321 55 compared compare VBN cord-005453-4057qib7 15321 56 to to IN cord-005453-4057qib7 15321 57 identical identical JJ cord-005453-4057qib7 15321 58 sibling sibling NN cord-005453-4057qib7 15321 59 donor donor NN cord-005453-4057qib7 15321 60 HSCT(ISD hsct(isd NN cord-005453-4057qib7 15321 61 - - HYPH cord-005453-4057qib7 15321 62 HSCT HSCT NNP cord-005453-4057qib7 15321 63 ) ) -RRB- cord-005453-4057qib7 15321 64 in in IN cord-005453-4057qib7 15321 65 high high JJ cord-005453-4057qib7 15321 66 - - HYPH cord-005453-4057qib7 15321 67 risk risk NN cord-005453-4057qib7 15321 68 features feature NNS cord-005453-4057qib7 15321 69 .but .but . cord-005453-4057qib7 15322 1 in in IN cord-005453-4057qib7 15322 2 refractory refractory JJ cord-005453-4057qib7 15322 3 / / SYM cord-005453-4057qib7 15322 4 relapsed(R relapsed(R NNP cord-005453-4057qib7 15322 5 / / SYM cord-005453-4057qib7 15322 6 R r NN cord-005453-4057qib7 15322 7 ) ) -RRB- cord-005453-4057qib7 15322 8 AML AML NNP cord-005453-4057qib7 15322 9 patients patient NNS cord-005453-4057qib7 15322 10 who who WP cord-005453-4057qib7 15322 11 not not RB cord-005453-4057qib7 15322 12 in in IN cord-005453-4057qib7 15322 13 remission remission NN cord-005453-4057qib7 15322 14 status status NN cord-005453-4057qib7 15322 15 , , , cord-005453-4057qib7 15322 16 it -PRON- PRP cord-005453-4057qib7 15322 17 is be VBZ cord-005453-4057qib7 15322 18 unclear unclear JJ cord-005453-4057qib7 15322 19 whether whether IN cord-005453-4057qib7 15322 20 it -PRON- PRP cord-005453-4057qib7 15322 21 also also RB cord-005453-4057qib7 15322 22 augments augment VBZ cord-005453-4057qib7 15322 23 the the DT cord-005453-4057qib7 15322 24 GVL GVL NNP cord-005453-4057qib7 15322 25 effect effect NN cord-005453-4057qib7 15322 26 Antithymocyte Antithymocyte NNP cord-005453-4057qib7 15322 27 globulin globulin NN cord-005453-4057qib7 15322 28 was be VBD cord-005453-4057qib7 15322 29 used use VBN cord-005453-4057qib7 15322 30 in in IN cord-005453-4057qib7 15322 31 haploidentical haploidentical JJ cord-005453-4057qib7 15322 32 HSCT HSCT NNP cord-005453-4057qib7 15322 33 . . . cord-005453-4057qib7 15323 1 unmanipulated unmanipulated JJ cord-005453-4057qib7 15323 2 bone bone NN cord-005453-4057qib7 15323 3 marrow marrow NN cord-005453-4057qib7 15323 4 and and CC cord-005453-4057qib7 15323 5 peripheral peripheral JJ cord-005453-4057qib7 15323 6 blood blood NN cord-005453-4057qib7 15323 7 stem stem NN cord-005453-4057qib7 15323 8 cells cell NNS cord-005453-4057qib7 15323 9 for for IN cord-005453-4057qib7 15323 10 all all DT cord-005453-4057qib7 15323 11 patients patient NNS cord-005453-4057qib7 15323 12 . . . cord-005453-4057qib7 15324 1 Cyclosporine cyclosporine JJ cord-005453-4057qib7 15324 2 , , , cord-005453-4057qib7 15324 3 short short JJ cord-005453-4057qib7 15324 4 - - HYPH cord-005453-4057qib7 15324 5 term term NN cord-005453-4057qib7 15324 6 Methotrexate Methotrexate NNP cord-005453-4057qib7 15324 7 were be VBD cord-005453-4057qib7 15324 8 employed employ VBN cord-005453-4057qib7 15324 9 for for IN cord-005453-4057qib7 15324 10 GVHD GVHD NNP cord-005453-4057qib7 15324 11 prophylaxis prophylaxis NN cord-005453-4057qib7 15324 12 . . . cord-005453-4057qib7 15325 1 Mycophenolate Mycophenolate NNP cord-005453-4057qib7 15325 2 mofetil mofetil NNP cord-005453-4057qib7 15325 3 included include VBD cord-005453-4057qib7 15325 4 in in IN cord-005453-4057qib7 15325 5 HID HID NNP cord-005453-4057qib7 15325 6 - - HYPH cord-005453-4057qib7 15325 7 HSCT HSCT NNP cord-005453-4057qib7 15325 8 . . . cord-005453-4057qib7 15326 1 performed perform VBN cord-005453-4057qib7 15326 2 multivariate multivariate JJ cord-005453-4057qib7 15326 3 analysis analysis NN cord-005453-4057qib7 15326 4 for for IN cord-005453-4057qib7 15326 5 all all DT cord-005453-4057qib7 15326 6 patients patient NNS cord-005453-4057qib7 15326 7 of of IN cord-005453-4057qib7 15326 8 pretransplantation pretransplantation NN cord-005453-4057qib7 15326 9 variables variable NNS cord-005453-4057qib7 15326 10 and and CC cord-005453-4057qib7 15326 11 developed develop VBD cord-005453-4057qib7 15326 12 a a DT cord-005453-4057qib7 15326 13 predictive predictive JJ cord-005453-4057qib7 15326 14 scoring scoring NN cord-005453-4057qib7 15326 15 system system NN cord-005453-4057qib7 15326 16 for for IN cord-005453-4057qib7 15326 17 survival survival NN cord-005453-4057qib7 15326 18 according accord VBG cord-005453-4057qib7 15326 19 to to IN cord-005453-4057qib7 15326 20 adverse adverse JJ cord-005453-4057qib7 15326 21 factors factor NNS cord-005453-4057qib7 15326 22 . . . cord-005453-4057qib7 15327 1 Results result NNS cord-005453-4057qib7 15327 2 : : : cord-005453-4057qib7 15328 1 The the DT cord-005453-4057qib7 15328 2 total total JJ cord-005453-4057qib7 15328 3 survivor survivor NN cord-005453-4057qib7 15328 4 median median JJ cord-005453-4057qib7 15328 5 period period NN cord-005453-4057qib7 15328 6 of of IN cord-005453-4057qib7 15328 7 follow follow NN cord-005453-4057qib7 15328 8 up up RP cord-005453-4057qib7 15328 9 was be VBD cord-005453-4057qib7 15328 10 46 46 CD cord-005453-4057qib7 15328 11 ( ( -LRB- cord-005453-4057qib7 15328 12 20 20 CD cord-005453-4057qib7 15328 13 - - SYM cord-005453-4057qib7 15328 14 73 73 CD cord-005453-4057qib7 15328 15 ) ) -RRB- cord-005453-4057qib7 15328 16 months month NNS cord-005453-4057qib7 15328 17 . . . cord-005453-4057qib7 15329 1 HID HID NNP cord-005453-4057qib7 15329 2 -cohort -cohort RB cord-005453-4057qib7 15329 3 had have VBD cord-005453-4057qib7 15329 4 higher high JJR cord-005453-4057qib7 15329 5 5-year 5-year CD cord-005453-4057qib7 15329 6 actuarial actuarial NN cord-005453-4057qib7 15329 7 of of IN cord-005453-4057qib7 15329 8 OS OS NNP cord-005453-4057qib7 15329 9 Multivariate Multivariate NNP cord-005453-4057qib7 15329 10 analysis analysis NN cord-005453-4057qib7 15329 11 showed show VBD cord-005453-4057qib7 15329 12 ISD ISD NNP cord-005453-4057qib7 15329 13 - - HYPH cord-005453-4057qib7 15329 14 HSCT HSCT NNP cord-005453-4057qib7 15329 15 , , , cord-005453-4057qib7 15329 16 standard standard JJ cord-005453-4057qib7 15329 17 conditioning conditioning NN cord-005453-4057qib7 15329 18 regimen regimen NN cord-005453-4057qib7 15329 19 and and CC cord-005453-4057qib7 15329 20 less less JJR cord-005453-4057qib7 15329 21 than than IN cord-005453-4057qib7 15329 22 50 50 CD cord-005453-4057qib7 15329 23 % % NN cord-005453-4057qib7 15329 24 proportional proportional JJ cord-005453-4057qib7 15329 25 reduction reduction NN cord-005453-4057qib7 15329 26 in in IN cord-005453-4057qib7 15329 27 blast blast NN cord-005453-4057qib7 15329 28 percentage percentage NN cord-005453-4057qib7 15329 29 pre-≥2 pre-≥2 NN cord-005453-4057qib7 15329 30 . . . cord-005453-4057qib7 15330 1 Conclusions conclusion NNS cord-005453-4057qib7 15330 2 : : : cord-005453-4057qib7 15331 1 Haploidentical haploidentical JJ cord-005453-4057qib7 15331 2 donor donor NN cord-005453-4057qib7 15331 3 compared compare VBN cord-005453-4057qib7 15331 4 to to IN cord-005453-4057qib7 15331 5 identical identical JJ cord-005453-4057qib7 15331 6 sibling sibling NN cord-005453-4057qib7 15331 7 donor donor NN cord-005453-4057qib7 15331 8 had have VBD cord-005453-4057qib7 15332 1 better well JJR cord-005453-4057qib7 15332 2 anti anti JJ cord-005453-4057qib7 15332 3 - - JJ cord-005453-4057qib7 15332 4 leukemia leukemia JJ cord-005453-4057qib7 15332 5 effect effect NN cord-005453-4057qib7 15332 6 in in IN cord-005453-4057qib7 15332 7 allo allo NN cord-005453-4057qib7 15332 8 - - HYPH cord-005453-4057qib7 15332 9 HSCT HSCT NNP cord-005453-4057qib7 15332 10 for for IN cord-005453-4057qib7 15332 11 R R NNP cord-005453-4057qib7 15332 12 / / SYM cord-005453-4057qib7 15332 13 R R NNP cord-005453-4057qib7 15332 14 AML AML NNP cord-005453-4057qib7 15332 15 in in IN cord-005453-4057qib7 15332 16 NR NR NNP cord-005453-4057qib7 15332 17 status status NN cord-005453-4057qib7 15332 18 Conditioning conditioning NN cord-005453-4057qib7 15332 19 protocol protocol NN cord-005453-4057qib7 15332 20 was be VBD cord-005453-4057qib7 15332 21 melphalan melphalan NNP cord-005453-4057qib7 15332 22 200mg 200mg NNP cord-005453-4057qib7 15332 23 / / SYM cord-005453-4057qib7 15332 24 m2 m2 NNP cord-005453-4057qib7 15332 25 for for IN cord-005453-4057qib7 15332 26 MM MM NNP cord-005453-4057qib7 15332 27 and and CC cord-005453-4057qib7 15332 28 BEAM BEAM NNP cord-005453-4057qib7 15332 29 for for IN cord-005453-4057qib7 15332 30 NHL NHL NNP cord-005453-4057qib7 15332 31 . . . cord-005453-4057qib7 15333 1 The the DT cord-005453-4057qib7 15333 2 quantification quantification NN cord-005453-4057qib7 15333 3 and and CC cord-005453-4057qib7 15333 4 characterization characterization NN cord-005453-4057qib7 15333 5 of of IN cord-005453-4057qib7 15333 6 γδT γδt NN cord-005453-4057qib7 15333 7 cells cell NNS cord-005453-4057qib7 15333 8 in in IN cord-005453-4057qib7 15333 9 peripheral peripheral JJ cord-005453-4057qib7 15333 10 blood blood NN cord-005453-4057qib7 15333 11 samples sample NNS cord-005453-4057qib7 15333 12 were be VBD cord-005453-4057qib7 15333 13 performed perform VBN cord-005453-4057qib7 15333 14 by by IN cord-005453-4057qib7 15333 15 flow flow NN cord-005453-4057qib7 15333 16 cytometry cytometry NN cord-005453-4057qib7 15333 17 based base VBN cord-005453-4057qib7 15333 18 on on IN cord-005453-4057qib7 15333 19 the the DT cord-005453-4057qib7 15333 20 expression expression NN cord-005453-4057qib7 15333 21 of of IN cord-005453-4057qib7 15333 22 CD3 CD3 NNP cord-005453-4057qib7 15333 23 / / SYM cord-005453-4057qib7 15333 24 CD45 CD45 NNP cord-005453-4057qib7 15333 25 / / SYM cord-005453-4057qib7 15333 26 Vδ1 Vδ1 NNP cord-005453-4057qib7 15333 27 / / SYM cord-005453-4057qib7 15333 28 Vδ2 vδ2 NN cord-005453-4057qib7 15333 29 / / SYM cord-005453-4057qib7 15333 30 Vγ9/ vγ9/ XX cord-005453-4057qib7 15334 1 CD27 CD27 NNP cord-005453-4057qib7 15334 2 at at IN cord-005453-4057qib7 15334 3 30 30 CD cord-005453-4057qib7 15334 4 , , , cord-005453-4057qib7 15334 5 60 60 CD cord-005453-4057qib7 15334 6 and and CC cord-005453-4057qib7 15334 7 100 100 CD cord-005453-4057qib7 15334 8 days day NNS cord-005453-4057qib7 15334 9 after after IN cord-005453-4057qib7 15334 10 aHSCT ahsct NN cord-005453-4057qib7 15334 11 . . . cord-005453-4057qib7 15335 1 Percentage percentage NN cord-005453-4057qib7 15335 2 ( ( -LRB- cord-005453-4057qib7 15335 3 % % NN cord-005453-4057qib7 15335 4 ) ) -RRB- cord-005453-4057qib7 15335 5 of of IN cord-005453-4057qib7 15335 6 γδT γδt NN cord-005453-4057qib7 15335 7 cells cell NNS cord-005453-4057qib7 15335 8 represented represent VBD cord-005453-4057qib7 15335 9 the the DT cord-005453-4057qib7 15335 10 proportion proportion NN cord-005453-4057qib7 15335 11 of of IN cord-005453-4057qib7 15335 12 these these DT cord-005453-4057qib7 15335 13 cells cell NNS cord-005453-4057qib7 15335 14 among among IN cord-005453-4057qib7 15335 15 all all DT cord-005453-4057qib7 15335 16 T t NN cord-005453-4057qib7 15335 17 cells cell NNS cord-005453-4057qib7 15335 18 . . . cord-005453-4057qib7 15336 1 Results result NNS cord-005453-4057qib7 15336 2 : : : cord-005453-4057qib7 15337 1 Median median JJ cord-005453-4057qib7 15337 2 age age NN cord-005453-4057qib7 15337 3 at at IN cord-005453-4057qib7 15337 4 aHSCT aHSCT NNP cord-005453-4057qib7 15337 5 was be VBD cord-005453-4057qib7 15338 1 61 61 CD cord-005453-4057qib7 15338 2 ( ( -LRB- cord-005453-4057qib7 15338 3 40 40 CD cord-005453-4057qib7 15338 4 - - SYM cord-005453-4057qib7 15338 5 70 70 CD cord-005453-4057qib7 15338 6 ) ) -RRB- cord-005453-4057qib7 15338 7 years year NNS cord-005453-4057qib7 15338 8 , , , cord-005453-4057qib7 15338 9 63 63 CD cord-005453-4057qib7 15338 10 % % NN cord-005453-4057qib7 15338 11 male male NN cord-005453-4057qib7 15338 12 . . . cord-005453-4057qib7 15339 1 Median median JJ cord-005453-4057qib7 15339 2 time time NN cord-005453-4057qib7 15339 3 from from IN cord-005453-4057qib7 15339 4 diagnosis diagnosis NN cord-005453-4057qib7 15339 5 to to IN cord-005453-4057qib7 15339 6 mobilization mobilization NN cord-005453-4057qib7 15339 7 was be VBD cord-005453-4057qib7 15339 8 8 8 CD cord-005453-4057qib7 15339 9 ( ( -LRB- cord-005453-4057qib7 15339 10 4 4 CD cord-005453-4057qib7 15339 11 - - SYM cord-005453-4057qib7 15339 12 52 52 CD cord-005453-4057qib7 15339 13 ) ) -RRB- cord-005453-4057qib7 15339 14 months month NNS cord-005453-4057qib7 15339 15 , , , cord-005453-4057qib7 15339 16 after after IN cord-005453-4057qib7 15339 17 a a DT cord-005453-4057qib7 15339 18 median median JJ cord-005453-4057qib7 15339 19 number number NN cord-005453-4057qib7 15339 20 of of IN cord-005453-4057qib7 15339 21 therapeutic therapeutic JJ cord-005453-4057qib7 15339 22 lines line NNS cord-005453-4057qib7 15339 23 of of IN cord-005453-4057qib7 15339 24 1 1 CD cord-005453-4057qib7 15339 25 ( ( -LRB- cord-005453-4057qib7 15339 26 1 1 CD cord-005453-4057qib7 15339 27 - - SYM cord-005453-4057qib7 15339 28 3 3 CD cord-005453-4057qib7 15339 29 ) ) -RRB- cord-005453-4057qib7 15339 30 ; ; : cord-005453-4057qib7 15339 31 7pts 7pts CD cord-005453-4057qib7 15339 32 ( ( -LRB- cord-005453-4057qib7 15339 33 13.0 13.0 CD cord-005453-4057qib7 15339 34 % % NN cord-005453-4057qib7 15339 35 ) ) -RRB- cord-005453-4057qib7 15339 36 received receive VBD cord-005453-4057qib7 15339 37 radiotherapy radiotherapy NN cord-005453-4057qib7 15339 38 . . . cord-005453-4057qib7 15340 1 Seventeen seventeen CD cord-005453-4057qib7 15340 2 pts pts NN cord-005453-4057qib7 15340 3 ( ( -LRB- cord-005453-4057qib7 15340 4 31.5 31.5 CD cord-005453-4057qib7 15340 5 % % NN cord-005453-4057qib7 15340 6 ) ) -RRB- cord-005453-4057qib7 15340 7 were be VBD cord-005453-4057qib7 15340 8 re re VBN cord-005453-4057qib7 15340 9 - - VBN cord-005453-4057qib7 15340 10 mobilized mobilize VBN cord-005453-4057qib7 15340 11 with with IN cord-005453-4057qib7 15340 12 plerixafor±G plerixafor±G NNP cord-005453-4057qib7 15340 13 - - HYPH cord-005453-4057qib7 15340 14 CSF CSF NNP cord-005453-4057qib7 15340 15 ( ( -LRB- cord-005453-4057qib7 15340 16 25 25 CD cord-005453-4057qib7 15340 17 % % NN cord-005453-4057qib7 15340 18 MM MM NNP cord-005453-4057qib7 15340 19 vs vs IN cord-005453-4057qib7 15340 20 60 60 CD cord-005453-4057qib7 15340 21 % % NN cord-005453-4057qib7 15340 22 NHL NHL NNP cord-005453-4057qib7 15340 23 There there EX cord-005453-4057qib7 15340 24 was be VBD cord-005453-4057qib7 15340 25 no no DT cord-005453-4057qib7 15340 26 difference difference NN cord-005453-4057qib7 15340 27 in in IN cord-005453-4057qib7 15340 28 febrile febrile JJ cord-005453-4057qib7 15340 29 neutropenia neutropenia NN cord-005453-4057qib7 15340 30 incidence incidence NN cord-005453-4057qib7 15340 31 ( ( -LRB- cord-005453-4057qib7 15340 32 p=0.766 p=0.766 NNP cord-005453-4057qib7 15340 33 ) ) -RRB- cord-005453-4057qib7 15340 34 , , , cord-005453-4057qib7 15340 35 timeto timeto NN cord-005453-4057qib7 15340 36 - - HYPH cord-005453-4057qib7 15340 37 engraftment engraftment NN cord-005453-4057qib7 15340 38 ( ( -LRB- cord-005453-4057qib7 15340 39 p=0.093 p=0.093 NNP cord-005453-4057qib7 15340 40 ) ) -RRB- cord-005453-4057qib7 15340 41 , , , cord-005453-4057qib7 15340 42 time time NN cord-005453-4057qib7 15340 43 - - HYPH cord-005453-4057qib7 15340 44 to to IN cord-005453-4057qib7 15340 45 - - HYPH cord-005453-4057qib7 15340 46 neutrophils>500 neutrophils>500 NNP cord-005453-4057qib7 15340 47 / / SYM cord-005453-4057qib7 15340 48 μL μL NNP cord-005453-4057qib7 15340 49 ( ( -LRB- cord-005453-4057qib7 15340 50 p=0.174 p=0.174 JJ cord-005453-4057qib7 15340 51 ) ) -RRB- cord-005453-4057qib7 15340 52 or or CC cord-005453-4057qib7 15340 53 erythrocyte erythrocyte NN cord-005453-4057qib7 15340 54 transfusions transfusion NNS cord-005453-4057qib7 15340 55 ( ( -LRB- cord-005453-4057qib7 15340 56 p=0.076 p=0.076 NNP cord-005453-4057qib7 15340 57 ) ) -RRB- cord-005453-4057qib7 15340 58 . . . cord-005453-4057qib7 15341 1 However however RB cord-005453-4057qib7 15341 2 , , , cord-005453-4057qib7 15341 3 there there EX cord-005453-4057qib7 15341 4 was be VBD cord-005453-4057qib7 15341 5 more more JJR cord-005453-4057qib7 15341 6 time time NN cord-005453-4057qib7 15341 7 - - HYPH cord-005453-4057qib7 15341 8 to to IN cord-005453-4057qib7 15341 9 - - HYPH cord-005453-4057qib7 15341 10 platelets>20,000/ platelets>20,000/ NN cord-005453-4057qib7 15342 1 μL μL NNP cord-005453-4057qib7 15342 2 ( ( -LRB- cord-005453-4057qib7 15342 3 4 4 CD cord-005453-4057qib7 15342 4 vs vs IN cord-005453-4057qib7 15342 5 8 8 CD cord-005453-4057qib7 15342 6 days day NNS cord-005453-4057qib7 15342 7 ; ; : cord-005453-4057qib7 15342 8 subpopulations subpopulation NNS cord-005453-4057qib7 15342 9 did do VBD cord-005453-4057qib7 15342 10 not not RB cord-005453-4057qib7 15342 11 affected affect VBN cord-005453-4057qib7 15342 12 PFS PFS NNP cord-005453-4057qib7 15342 13 . . . cord-005453-4057qib7 15343 1 Conclusions conclusion NNS cord-005453-4057qib7 15343 2 : : : cord-005453-4057qib7 15344 1 Our -PRON- PRP$ cord-005453-4057qib7 15344 2 results result NNS cord-005453-4057qib7 15344 3 showed show VBD cord-005453-4057qib7 15344 4 that that IN cord-005453-4057qib7 15344 5 pts pt NNS cord-005453-4057qib7 15344 6 mobilized mobilize VBN cord-005453-4057qib7 15344 7 with with IN cord-005453-4057qib7 15344 8 plerixafor plerixafor NN cord-005453-4057qib7 15344 9 need need VBP cord-005453-4057qib7 15344 10 more more JJR cord-005453-4057qib7 15344 11 collection collection NN cord-005453-4057qib7 15344 12 volume volume NN cord-005453-4057qib7 15344 13 ( ( -LRB- cord-005453-4057qib7 15344 14 less less RBR cord-005453-4057qib7 15344 15 CD34+cells CD34+cells NNPS cord-005453-4057qib7 15344 16 , , , cord-005453-4057qib7 15344 17 higher high JJR cord-005453-4057qib7 15344 18 DMSO DMSO NNP cord-005453-4057qib7 15344 19 ) ) -RRB- cord-005453-4057qib7 15344 20 . . . cord-005453-4057qib7 15345 1 Plerixafor Plerixafor NNP cord-005453-4057qib7 15345 2 negatively negatively RB cord-005453-4057qib7 15345 3 affected affect VBD cord-005453-4057qib7 15345 4 platelet platelet NN cord-005453-4057qib7 15345 5 recovery recovery NN cord-005453-4057qib7 15345 6 , , , cord-005453-4057qib7 15345 7 with with IN cord-005453-4057qib7 15345 8 similar similar JJ cord-005453-4057qib7 15345 9 hematologic hematologic JJ cord-005453-4057qib7 15345 10 and and CC cord-005453-4057qib7 15345 11 immune immune JJ cord-005453-4057qib7 15345 12 recovery recovery NN cord-005453-4057qib7 15345 13 for for IN cord-005453-4057qib7 15345 14 the the DT cord-005453-4057qib7 15345 15 remaining remain VBG cord-005453-4057qib7 15345 16 variables variable NNS cord-005453-4057qib7 15345 17 . . . cord-005453-4057qib7 15346 1 Its -PRON- PRP$ cord-005453-4057qib7 15346 2 use use NN cord-005453-4057qib7 15346 3 was be VBD cord-005453-4057qib7 15346 4 associated associate VBN cord-005453-4057qib7 15346 5 with with IN cord-005453-4057qib7 15346 6 higher high JJR cord-005453-4057qib7 15346 7 % % NN cord-005453-4057qib7 15346 8 Vδ1 vδ1 NN cord-005453-4057qib7 15346 9 + + SYM cord-005453-4057qib7 15346 10 , , , cord-005453-4057qib7 15346 11 suggesting suggest VBG cord-005453-4057qib7 15346 12 that that IN cord-005453-4057qib7 15346 13 it -PRON- PRP cord-005453-4057qib7 15346 14 induces induce VBZ cord-005453-4057qib7 15346 15 an an DT cord-005453-4057qib7 15346 16 antineoplastic antineoplastic JJ cord-005453-4057qib7 15346 17 phenotype phenotype NN cord-005453-4057qib7 15346 18 . . . cord-005453-4057qib7 15347 1 More More JJR cord-005453-4057qib7 15347 2 studies study NNS cord-005453-4057qib7 15347 3 with with IN cord-005453-4057qib7 15347 4 larger large JJR cord-005453-4057qib7 15347 5 samples sample NNS cord-005453-4057qib7 15347 6 and and CC cord-005453-4057qib7 15347 7 follow follow VB cord-005453-4057qib7 15347 8 - - HYPH cord-005453-4057qib7 15347 9 up up NN cord-005453-4057qib7 15347 10 period period NN cord-005453-4057qib7 15347 11 are be VBP cord-005453-4057qib7 15347 12 needed need VBN cord-005453-4057qib7 15347 13 to to TO cord-005453-4057qib7 15347 14 evaluate evaluate VB cord-005453-4057qib7 15347 15 plerixafor plerixafor NN cord-005453-4057qib7 15347 16 Results result NNS cord-005453-4057qib7 15347 17 : : : cord-005453-4057qib7 15348 1 Total total JJ cord-005453-4057qib7 15348 2 1156 1156 CD cord-005453-4057qib7 15348 3 ASCC ASCC NNP cord-005453-4057qib7 15348 4 procedures procedure NNS cord-005453-4057qib7 15348 5 were be VBD cord-005453-4057qib7 15348 6 carried carry VBN cord-005453-4057qib7 15348 7 out out RP cord-005453-4057qib7 15348 8 in in IN cord-005453-4057qib7 15348 9 1072 1072 CD cord-005453-4057qib7 15348 10 patients patient NNS cord-005453-4057qib7 15348 11 over over IN cord-005453-4057qib7 15348 12 18 18 CD cord-005453-4057qib7 15348 13 years year NNS cord-005453-4057qib7 15348 14 , , , cord-005453-4057qib7 15348 15 once once RB cord-005453-4057qib7 15348 16 in in IN cord-005453-4057qib7 15348 17 985 985 CD cord-005453-4057qib7 15348 18 patients patient NNS cord-005453-4057qib7 15348 19 , , , cord-005453-4057qib7 15348 20 twice twice RB cord-005453-4057qib7 15348 21 in in IN cord-005453-4057qib7 15348 22 83 83 CD cord-005453-4057qib7 15348 23 patients patient NNS cord-005453-4057qib7 15348 24 , , , cord-005453-4057qib7 15348 25 three three CD cord-005453-4057qib7 15348 26 times time NNS cord-005453-4057qib7 15348 27 in in IN cord-005453-4057qib7 15348 28 3 3 CD cord-005453-4057qib7 15348 29 patients patient NNS cord-005453-4057qib7 15348 30 , , , cord-005453-4057qib7 15348 31 and and CC cord-005453-4057qib7 15348 32 four four CD cord-005453-4057qib7 15348 33 times time NNS cord-005453-4057qib7 15348 34 in in IN cord-005453-4057qib7 15348 35 1 1 CD cord-005453-4057qib7 15348 36 patient patient NN cord-005453-4057qib7 15348 37 . . . cord-005453-4057qib7 15349 1 Non Non NNP cord-005453-4057qib7 15349 2 - - JJ cord-005453-4057qib7 15349 3 Hodgkin Hodgkin NNP cord-005453-4057qib7 15349 4 lymphoma lymphoma NN cord-005453-4057qib7 15349 5 ( ( -LRB- cord-005453-4057qib7 15349 6 NHL NHL NNP cord-005453-4057qib7 15349 7 ) ) -RRB- cord-005453-4057qib7 15349 8 comprised comprise VBD cord-005453-4057qib7 15349 9 56.7 56.7 CD cord-005453-4057qib7 15349 10 % % NN cord-005453-4057qib7 15349 11 of of IN cord-005453-4057qib7 15349 12 all all DT cord-005453-4057qib7 15349 13 cases case NNS cord-005453-4057qib7 15349 14 ( ( -LRB- cord-005453-4057qib7 15349 15 n n NN cord-005453-4057qib7 15349 16 = = SYM cord-005453-4057qib7 15349 17 655 655 CD cord-005453-4057qib7 15349 18 ) ) -RRB- cord-005453-4057qib7 15349 19 001 001 CD cord-005453-4057qib7 15349 20 ) ) -RRB- cord-005453-4057qib7 15349 21 , , , cord-005453-4057qib7 15349 22 total total JJ cord-005453-4057qib7 15349 23 number number NN cord-005453-4057qib7 15349 24 of of IN cord-005453-4057qib7 15349 25 chemotherapy chemotherapy NN cord-005453-4057qib7 15349 26 cycles cycle NNS cord-005453-4057qib7 15349 27 before before IN cord-005453-4057qib7 15349 28 ASCC ASCC NNP cord-005453-4057qib7 15349 29 ( ( -LRB- cord-005453-4057qib7 15349 30 OR or CC cord-005453-4057qib7 15349 31 1.06 1.06 CD cord-005453-4057qib7 15349 32 , , , cord-005453-4057qib7 15349 33 95 95 CD cord-005453-4057qib7 15349 34 % % NN cord-005453-4057qib7 15349 35 CI CI NNP cord-005453-4057qib7 15349 36 1.004 1.004 CD cord-005453-4057qib7 15349 37 - - HYPH cord-005453-4057qib7 15349 38 1.13 1.13 CD cord-005453-4057qib7 15349 39 , , , cord-005453-4057qib7 15349 40 p p NN cord-005453-4057qib7 15349 41 = = SYM cord-005453-4057qib7 15349 42 0.035 0.035 CD cord-005453-4057qib7 15349 43 ) ) -RRB- cord-005453-4057qib7 15349 44 , , , cord-005453-4057qib7 15349 45 failure failure NN cord-005453-4057qib7 15349 46 to to TO cord-005453-4057qib7 15349 47 achieve achieve VB cord-005453-4057qib7 15349 48 at at IN cord-005453-4057qib7 15349 49 least least JJS cord-005453-4057qib7 15349 50 partial partial JJ cord-005453-4057qib7 15349 51 response response NN cord-005453-4057qib7 15349 52 before before IN cord-005453-4057qib7 15349 53 ASCC ASCC NNP cord-005453-4057qib7 15349 54 ( ( -LRB- cord-005453-4057qib7 15349 55 OR or CC cord-005453-4057qib7 15350 1 2.97 2.97 CD cord-005453-4057qib7 15350 2 , , , cord-005453-4057qib7 15350 3 95 95 CD cord-005453-4057qib7 15350 4 % % NN cord-005453-4057qib7 15350 5 CI CI NNP cord-005453-4057qib7 15350 6 1.01 1.01 CD cord-005453-4057qib7 15350 7 - - HYPH cord-005453-4057qib7 15350 8 8.73 8.73 CD cord-005453-4057qib7 15350 9 , , , cord-005453-4057qib7 15350 10 p p NN cord-005453-4057qib7 15350 11 = = SYM cord-005453-4057qib7 15350 12 0.048 0.048 CD cord-005453-4057qib7 15350 13 ) ) -RRB- cord-005453-4057qib7 15350 14 , , , cord-005453-4057qib7 15350 15 total total JJ cord-005453-4057qib7 15350 16 number number NN cord-005453-4057qib7 15350 17 of of IN cord-005453-4057qib7 15350 18 days day NNS cord-005453-4057qib7 15350 19 receiving receive VBG cord-005453-4057qib7 15350 20 G G NNP cord-005453-4057qib7 15350 21 - - HYPH cord-005453-4057qib7 15350 22 CSF CSF NNP cord-005453-4057qib7 15350 23 for for IN cord-005453-4057qib7 15350 24 mobilization mobilization NN cord-005453-4057qib7 15350 25 ( ( -LRB- cord-005453-4057qib7 15350 26 OR or CC cord-005453-4057qib7 15350 27 1.10 1.10 CD cord-005453-4057qib7 15350 28 , , , cord-005453-4057qib7 15350 29 95 95 CD cord-005453-4057qib7 15350 30 % % NN cord-005453-4057qib7 15350 31 CI CI NNP cord-005453-4057qib7 15350 32 1.002 1.002 CD cord-005453-4057qib7 15350 33 - - HYPH cord-005453-4057qib7 15350 34 1.23 1.23 CD cord-005453-4057qib7 15350 35 , , , cord-005453-4057qib7 15350 36 p p NN cord-005453-4057qib7 15350 37 = = SYM cord-005453-4057qib7 15350 38 0.045 0.045 CD cord-005453-4057qib7 15350 39 ) ) -RRB- cord-005453-4057qib7 15350 40 , , , cord-005453-4057qib7 15350 41 and and CC cord-005453-4057qib7 15350 42 salvage salvage VB cord-005453-4057qib7 15350 43 use use NN cord-005453-4057qib7 15350 44 of of IN cord-005453-4057qib7 15350 45 plerixafor plerixafor NN cord-005453-4057qib7 15350 46 ( ( -LRB- cord-005453-4057qib7 15350 47 OR or CC cord-005453-4057qib7 15350 48 3.78 3.78 CD cord-005453-4057qib7 15350 49 , , , cord-005453-4057qib7 15350 50 95 95 CD cord-005453-4057qib7 15350 51 % % NN cord-005453-4057qib7 15350 52 CI CI NNP cord-005453-4057qib7 15350 53 1.92 1.92 CD cord-005453-4057qib7 15350 54 - - SYM cord-005453-4057qib7 15350 55 7.47 7.47 CD cord-005453-4057qib7 15350 56 , , , cord-005453-4057qib7 15350 57 p p NN cord-005453-4057qib7 15350 58 < < XX cord-005453-4057qib7 15350 59 0.001 0.001 CD cord-005453-4057qib7 15350 60 ) ) -RRB- cord-005453-4057qib7 15350 61 were be VBD cord-005453-4057qib7 15350 62 found find VBN cord-005453-4057qib7 15350 63 to to TO cord-005453-4057qib7 15350 64 be be VB cord-005453-4057qib7 15350 65 independent independent JJ cord-005453-4057qib7 15350 66 factors factor NNS cord-005453-4057qib7 15350 67 associated associate VBN cord-005453-4057qib7 15350 68 with with IN cord-005453-4057qib7 15350 69 failure failure NN cord-005453-4057qib7 15350 70 of of IN cord-005453-4057qib7 15350 71 ASCC ASCC NNP cord-005453-4057qib7 15350 72 . . . cord-005453-4057qib7 15351 1 At at IN cord-005453-4057qib7 15351 2 the the DT cord-005453-4057qib7 15351 3 end end NN cord-005453-4057qib7 15351 4 of of IN cord-005453-4057qib7 15351 5 the the DT cord-005453-4057qib7 15351 6 study study NN cord-005453-4057qib7 15351 7 period period NN cord-005453-4057qib7 15351 8 , , , cord-005453-4057qib7 15351 9 90.9 90.9 CD cord-005453-4057qib7 15351 10 % % NN cord-005453-4057qib7 15351 11 of of IN cord-005453-4057qib7 15351 12 successful successful JJ cord-005453-4057qib7 15351 13 collections collection NNS cord-005453-4057qib7 15351 14 ( ( -LRB- cord-005453-4057qib7 15351 15 n n NN cord-005453-4057qib7 15351 16 = = SYM cord-005453-4057qib7 15351 17 962/1058 962/1058 CD cord-005453-4057qib7 15351 18 ) ) -RRB- cord-005453-4057qib7 15351 19 were be VBD cord-005453-4057qib7 15351 20 used use VBN cord-005453-4057qib7 15351 21 for for IN cord-005453-4057qib7 15351 22 ASCT ASCT NNP cord-005453-4057qib7 15351 23 , , , cord-005453-4057qib7 15351 24 4.5 4.5 CD cord-005453-4057qib7 15351 25 % % NN cord-005453-4057qib7 15351 26 ( ( -LRB- cord-005453-4057qib7 15351 27 n=48/1056 n=48/1056 NNP cord-005453-4057qib7 15351 28 ) ) -RRB- cord-005453-4057qib7 15351 29 were be VBD cord-005453-4057qib7 15351 30 in in IN cord-005453-4057qib7 15351 31 storage storage NN cord-005453-4057qib7 15351 32 awaiting awaiting NN cord-005453-4057qib7 15351 33 transplantation transplantation NN cord-005453-4057qib7 15352 1 Hôpital Hôpital NNP cord-005453-4057qib7 15352 2 Necker Necker NNP cord-005453-4057qib7 15352 3 - - HYPH cord-005453-4057qib7 15352 4 Enfants Enfants NNP cord-005453-4057qib7 15353 1 Malades Malades NNP cord-005453-4057qib7 15353 2 Melf Melf NNP cord-005453-4057qib7 15353 3 140 140 CD cord-005453-4057qib7 15353 4 Methods method NNS cord-005453-4057qib7 15353 5 : : : cord-005453-4057qib7 15354 1 A a DT cord-005453-4057qib7 15354 2 total total JJ cord-005453-4057qib7 15354 3 103 103 CD cord-005453-4057qib7 15354 4 AHSCT AHSCT NNP cord-005453-4057qib7 15354 5 candidates candidate NNS cord-005453-4057qib7 15354 6 [ [ -LRB- cord-005453-4057qib7 15354 7 median median NN cord-005453-4057qib7 15354 8 age age NN cord-005453-4057qib7 15354 9 : : : cord-005453-4057qib7 15354 10 57(18 57(18 CD cord-005453-4057qib7 15354 11 - - SYM cord-005453-4057qib7 15354 12 75 75 CD cord-005453-4057qib7 15354 13 ) ) -RRB- cord-005453-4057qib7 15354 14 years year NNS cord-005453-4057qib7 15354 15 ; ; : cord-005453-4057qib7 15354 16 male male JJ cord-005453-4057qib7 15354 17 / / SYM cord-005453-4057qib7 15354 18 female female JJ cord-005453-4057qib7 15354 19 : : : cord-005453-4057qib7 15354 20 54/49 54/49 CD cord-005453-4057qib7 15354 21 ] ] -RRB- cord-005453-4057qib7 15354 22 were be VBD cord-005453-4057qib7 15354 23 included include VBN cord-005453-4057qib7 15354 24 in in IN cord-005453-4057qib7 15354 25 this this DT cord-005453-4057qib7 15354 26 study study NN cord-005453-4057qib7 15354 27 . . . cord-005453-4057qib7 15355 1 Twenty twenty CD cord-005453-4057qib7 15355 2 - - HYPH cord-005453-4057qib7 15355 3 seven seven CD cord-005453-4057qib7 15355 4 patients patient NNS cord-005453-4057qib7 15355 5 ( ( -LRB- cord-005453-4057qib7 15355 6 26.2 26.2 CD cord-005453-4057qib7 15355 7 % % NN cord-005453-4057qib7 15355 8 ) ) -RRB- cord-005453-4057qib7 15355 9 were be VBD cord-005453-4057qib7 15355 10 diagnosed diagnose VBN cord-005453-4057qib7 15355 11 as as IN cord-005453-4057qib7 15355 12 non non JJ cord-005453-4057qib7 15355 13 Hodgkin Hodgkin NNP cord-005453-4057qib7 15355 14 's 's POS cord-005453-4057qib7 15355 15 lymphoma lymphoma NN cord-005453-4057qib7 15355 16 , , , cord-005453-4057qib7 15355 17 8 8 CD cord-005453-4057qib7 15355 18 patients patient NNS cord-005453-4057qib7 15355 19 ( ( -LRB- cord-005453-4057qib7 15355 20 7.8 7.8 CD cord-005453-4057qib7 15355 21 % % NN cord-005453-4057qib7 15355 22 ) ) -RRB- cord-005453-4057qib7 15355 23 Hodgkin Hodgkin NNP cord-005453-4057qib7 15355 24 's 's POS cord-005453-4057qib7 15355 25 lymphoma lymphoma NN cord-005453-4057qib7 15355 26 , , , cord-005453-4057qib7 15355 27 52 52 CD cord-005453-4057qib7 15355 28 patients patient NNS cord-005453-4057qib7 15355 29 ( ( -LRB- cord-005453-4057qib7 15355 30 50.5 50.5 CD cord-005453-4057qib7 15355 31 % % NN cord-005453-4057qib7 15355 32 ) ) -RRB- cord-005453-4057qib7 15355 33 multiple multiple JJ cord-005453-4057qib7 15355 34 myeloma myeloma NN cord-005453-4057qib7 15355 35 , , , cord-005453-4057qib7 15355 36 12 12 CD cord-005453-4057qib7 15355 37 patients patient NNS cord-005453-4057qib7 15355 38 ( ( -LRB- cord-005453-4057qib7 15355 39 11.6 11.6 CD cord-005453-4057qib7 15355 40 % % NN cord-005453-4057qib7 15355 41 ) ) -RRB- cord-005453-4057qib7 15355 42 acute acute JJ cord-005453-4057qib7 15355 43 myeloid myeloid NN cord-005453-4057qib7 15355 44 leukemia leukemia NN cord-005453-4057qib7 15355 45 , , , cord-005453-4057qib7 15355 46 3 3 CD cord-005453-4057qib7 15355 47 patients patient NNS cord-005453-4057qib7 15355 48 ( ( -LRB- cord-005453-4057qib7 15355 49 2.9 2.9 CD cord-005453-4057qib7 15355 50 % % NN cord-005453-4057qib7 15355 51 ) ) -RRB- cord-005453-4057qib7 15355 52 plasmocytoma plasmocytoma NNP cord-005453-4057qib7 15355 53 and and CC cord-005453-4057qib7 15355 54 1 1 CD cord-005453-4057qib7 15355 55 patient patient NN cord-005453-4057qib7 15355 56 ( ( -LRB- cord-005453-4057qib7 15355 57 1 1 CD cord-005453-4057qib7 15355 58 % % NN cord-005453-4057qib7 15355 59 ) ) -RRB- cord-005453-4057qib7 15355 60 testis testis NN cord-005453-4057qib7 15355 61 cancer cancer NN cord-005453-4057qib7 15355 62 . . . cord-005453-4057qib7 15356 1 Premobilization Premobilization NNP cord-005453-4057qib7 15356 2 serum serum NN cord-005453-4057qib7 15356 3 25-hydroxy 25-hydroxy CD cord-005453-4057qib7 15356 4 vitamin vitamin NN cord-005453-4057qib7 15356 5 D d NN cord-005453-4057qib7 15356 6 ( ( -LRB- cord-005453-4057qib7 15356 7 25-OH 25-oh CD cord-005453-4057qib7 15356 8 D D NNP cord-005453-4057qib7 15356 9 ) ) -RRB- cord-005453-4057qib7 15356 10 levels level NNS cord-005453-4057qib7 15356 11 were be VBD cord-005453-4057qib7 15356 12 measured measure VBN cord-005453-4057qib7 15356 13 with with IN cord-005453-4057qib7 15356 14 immunoassay immunoassay JJ cord-005453-4057qib7 15356 15 method method NN cord-005453-4057qib7 15356 16 Peripheral Peripheral NNP cord-005453-4057qib7 15356 17 CD34 CD34 NNP cord-005453-4057qib7 15356 18 + + CC cord-005453-4057qib7 15357 1 cell cell NN cord-005453-4057qib7 15357 2 count count NN cord-005453-4057qib7 15357 3 Background Background NNP cord-005453-4057qib7 15357 4 : : : cord-005453-4057qib7 15358 1 Some some DT cord-005453-4057qib7 15358 2 published publish VBN cord-005453-4057qib7 15358 3 data datum NNS cord-005453-4057qib7 15358 4 suggest suggest VBP cord-005453-4057qib7 15358 5 a a DT cord-005453-4057qib7 15358 6 positive positive JJ cord-005453-4057qib7 15358 7 effect effect NN cord-005453-4057qib7 15358 8 of of IN cord-005453-4057qib7 15358 9 iron iron NN cord-005453-4057qib7 15358 10 chelators chelator NNS cord-005453-4057qib7 15358 11 on on IN cord-005453-4057qib7 15358 12 the the DT cord-005453-4057qib7 15358 13 risk risk NN cord-005453-4057qib7 15358 14 of of IN cord-005453-4057qib7 15358 15 post post JJ cord-005453-4057qib7 15358 16 - - JJ cord-005453-4057qib7 15358 17 transplant transplant JJ cord-005453-4057qib7 15358 18 relapse relapse NN cord-005453-4057qib7 15358 19 , , , cord-005453-4057qib7 15358 20 with with IN cord-005453-4057qib7 15358 21 an an DT cord-005453-4057qib7 15358 22 improvement improvement NN cord-005453-4057qib7 15358 23 in in IN cord-005453-4057qib7 15358 24 overall overall JJ cord-005453-4057qib7 15358 25 survival survival NN cord-005453-4057qib7 15358 26 after after IN cord-005453-4057qib7 15358 27 allogeneic allogeneic NN cord-005453-4057qib7 15358 28 hematopoietic hematopoietic JJ cord-005453-4057qib7 15358 29 stem stem NN cord-005453-4057qib7 15358 30 cell cell NN cord-005453-4057qib7 15358 31 transplantation transplantation NN cord-005453-4057qib7 15358 32 ( ( -LRB- cord-005453-4057qib7 15358 33 HSCT HSCT NNP cord-005453-4057qib7 15358 34 ) ) -RRB- cord-005453-4057qib7 15359 1 Conditioning conditioning NN cord-005453-4057qib7 15359 2 regimen regimen NN cord-005453-4057qib7 15359 3 consisted consist VBD cord-005453-4057qib7 15359 4 to to IN cord-005453-4057qib7 15359 5 intravenous intravenous JJ cord-005453-4057qib7 15359 6 Bu Bu NNP cord-005453-4057qib7 15359 7 130 130 CD cord-005453-4057qib7 15360 1 mg mg NNP cord-005453-4057qib7 15360 2 / / SYM cord-005453-4057qib7 15360 3 m m NN cord-005453-4057qib7 15360 4 2 2 CD cord-005453-4057qib7 15361 1 and and CC cord-005453-4057qib7 15361 2 , , , cord-005453-4057qib7 15361 3 Flu Flu NNP cord-005453-4057qib7 15361 4 40 40 CD cord-005453-4057qib7 15361 5 mg mg NNP cord-005453-4057qib7 15361 6 / / SYM cord-005453-4057qib7 15361 7 m m NN cord-005453-4057qib7 15361 8 2 2 CD cord-005453-4057qib7 15361 9 D-6 D-6 NNP cord-005453-4057qib7 15361 10 to to IN cord-005453-4057qib7 15361 11 D-3 D-3 NNP cord-005453-4057qib7 15361 12 . . . cord-005453-4057qib7 15362 1 GVHD GVHD NNP cord-005453-4057qib7 15362 2 prophylaxis prophylaxis NN cord-005453-4057qib7 15362 3 included include VBD cord-005453-4057qib7 15362 4 ATG ATG NNP cord-005453-4057qib7 15362 5 2.5 2.5 CD cord-005453-4057qib7 15362 6 mg mg NNP cord-005453-4057qib7 15362 7 / / SYM cord-005453-4057qib7 15362 8 kg kg NNS cord-005453-4057qib7 15362 9 on on IN cord-005453-4057qib7 15362 10 D-2 D-2 NNP cord-005453-4057qib7 15362 11 and and CC cord-005453-4057qib7 15362 12 D-1 D-1 NNP cord-005453-4057qib7 15362 13 , , , cord-005453-4057qib7 15362 14 ciclosporin ciclosporin NN cord-005453-4057qib7 15362 15 and and CC cord-005453-4057qib7 15362 16 methotrexate methotrexate NNP cord-005453-4057qib7 15362 17 . . . cord-005453-4057qib7 15363 1 All all DT cord-005453-4057qib7 15363 2 patients patient NNS cord-005453-4057qib7 15363 3 received receive VBD cord-005453-4057qib7 15363 4 peripheral peripheral JJ cord-005453-4057qib7 15363 5 blood blood NN cord-005453-4057qib7 15363 6 stem stem NN cord-005453-4057qib7 15363 7 cell cell NN cord-005453-4057qib7 15363 8 transplant transplant NN cord-005453-4057qib7 15363 9 from from IN cord-005453-4057qib7 15363 10 an an DT cord-005453-4057qib7 15363 11 identical identical JJ cord-005453-4057qib7 15363 12 HLA HLA NNP cord-005453-4057qib7 15363 13 - - HYPH cord-005453-4057qib7 15363 14 related relate VBN cord-005453-4057qib7 15363 15 donor donor NN cord-005453-4057qib7 15363 16 . . . cord-005453-4057qib7 15364 1 Iron iron NN cord-005453-4057qib7 15364 2 chelation chelation NN cord-005453-4057qib7 15364 3 consisted consist VBD cord-005453-4057qib7 15364 4 on on IN cord-005453-4057qib7 15364 5 deferasirox deferasirox NNP cord-005453-4057qib7 15364 6 ( ( -LRB- cord-005453-4057qib7 15364 7 Exjade Exjade NNP cord-005453-4057qib7 15364 8 ® ® NN cord-005453-4057qib7 15364 9 ) ) -RRB- cord-005453-4057qib7 15365 1 10 10 CD cord-005453-4057qib7 15365 2 - - SYM cord-005453-4057qib7 15365 3 20 20 CD cord-005453-4057qib7 15365 4 mg mg NNP cord-005453-4057qib7 15365 5 / / SYM cord-005453-4057qib7 15365 6 kg kg NNP cord-005453-4057qib7 15365 7 / / SYM cord-005453-4057qib7 15365 8 day day NN cord-005453-4057qib7 15365 9 , , , cord-005453-4057qib7 15365 10 started start VBD cord-005453-4057qib7 15365 11 at at IN cord-005453-4057qib7 15365 12 day day NN cord-005453-4057qib7 15365 13 100 100 CD cord-005453-4057qib7 15365 14 , , , cord-005453-4057qib7 15365 15 if if IN cord-005453-4057qib7 15365 16 serum serum NN cord-005453-4057qib7 15365 17 ferritin ferritin NN cord-005453-4057qib7 15365 18 level level NN cord-005453-4057qib7 15365 19 ≥ ≥ CD cord-005453-4057qib7 15365 20 800 800 CD cord-005453-4057qib7 15366 1 -1000 -1000 : cord-005453-4057qib7 15366 2 ug ug NNP cord-005453-4057qib7 15366 3 / / SYM cord-005453-4057qib7 15366 4 l l NNP cord-005453-4057qib7 15366 5 and and CC cord-005453-4057qib7 15366 6 stopped stop VBD cord-005453-4057qib7 15366 7 when when WRB cord-005453-4057qib7 15366 8 the the DT cord-005453-4057qib7 15366 9 level level NN cord-005453-4057qib7 15366 10 decreased decrease VBD cord-005453-4057qib7 15366 11 below below IN cord-005453-4057qib7 15366 12 600 600 CD cord-005453-4057qib7 15366 13 ug ug NNP cord-005453-4057qib7 15366 14 / / SYM cord-005453-4057qib7 15366 15 l l NN cord-005453-4057qib7 15366 16 or or CC cord-005453-4057qib7 15366 17 normalized normalize VBN cord-005453-4057qib7 15366 18 At at IN cord-005453-4057qib7 15366 19 day day NN cord-005453-4057qib7 15366 20 100 100 CD cord-005453-4057qib7 15366 21 after after IN cord-005453-4057qib7 15366 22 transplant transplant NN cord-005453-4057qib7 15367 1 , , , cord-005453-4057qib7 15367 2 35/ 35/ JJ cord-005453-4057qib7 15367 3 40 40 CD cord-005453-4057qib7 15367 4 patients patient NNS cord-005453-4057qib7 15367 5 were be VBD cord-005453-4057qib7 15367 6 evaluable evaluable JJ cord-005453-4057qib7 15367 7 ( ( -LRB- cord-005453-4057qib7 15367 8 G1= G1= NNP cord-005453-4057qib7 15367 9 20 20 CD cord-005453-4057qib7 15367 10 pts pt NNS cord-005453-4057qib7 15367 11 ) ) -RRB- cord-005453-4057qib7 15367 12 , , , cord-005453-4057qib7 15367 13 ( ( -LRB- cord-005453-4057qib7 15367 14 G2 G2 NNP cord-005453-4057qib7 15367 15 = = SYM cord-005453-4057qib7 15367 16 15 15 CD cord-005453-4057qib7 15367 17 pts pts NN cord-005453-4057qib7 15367 18 ) ) -RRB- cord-005453-4057qib7 15367 19 . . . cord-005453-4057qib7 15368 1 Patients patient NNS cord-005453-4057qib7 15368 2 were be VBD cord-005453-4057qib7 15368 3 ABO ABO NNP cord-005453-4057qib7 15368 4 compatible compatible JJ cord-005453-4057qib7 15368 5 ( ( -LRB- cord-005453-4057qib7 15368 6 66 66 CD cord-005453-4057qib7 15368 7 % % NN cord-005453-4057qib7 15368 8 ) ) -RRB- cord-005453-4057qib7 15368 9 , , , cord-005453-4057qib7 15368 10 had have VBD cord-005453-4057qib7 15368 11 major major JJ cord-005453-4057qib7 15368 12 incompatibility incompatibility NN cord-005453-4057qib7 15368 13 ( ( -LRB- cord-005453-4057qib7 15368 14 29 29 CD cord-005453-4057qib7 15368 15 % % NN cord-005453-4057qib7 15368 16 ) ) -RRB- cord-005453-4057qib7 15368 17 , , , cord-005453-4057qib7 15368 18 and and CC cord-005453-4057qib7 15368 19 6 6 CD cord-005453-4057qib7 15368 20 % % NN cord-005453-4057qib7 15368 21 had have VBD cord-005453-4057qib7 15368 22 minor minor JJ cord-005453-4057qib7 15368 23 incompatibility incompatibility NN cord-005453-4057qib7 15368 24 . . . cord-005453-4057qib7 15369 1 Median median JJ cord-005453-4057qib7 15369 2 serum serum NN cord-005453-4057qib7 15369 3 ferritin ferritin NN cord-005453-4057qib7 15369 4 level level NN cord-005453-4057qib7 15369 5 at at IN cord-005453-4057qib7 15369 6 day day NN cord-005453-4057qib7 15369 7 100 100 CD cord-005453-4057qib7 15369 8 , , , cord-005453-4057qib7 15369 9 were be VBD cord-005453-4057qib7 15369 10 1200 1200 CD cord-005453-4057qib7 15369 11 ug ug NNP cord-005453-4057qib7 15369 12 / / SYM cord-005453-4057qib7 15369 13 l l NN cord-005453-4057qib7 15369 14 ( ( -LRB- cord-005453-4057qib7 15369 15 833 833 CD cord-005453-4057qib7 15369 16 - - SYM cord-005453-4057qib7 15369 17 4449 4449 CD cord-005453-4057qib7 15369 18 ) ) -RRB- cord-005453-4057qib7 15369 19 and and CC cord-005453-4057qib7 15369 20 1200 1200 CD cord-005453-4057qib7 15369 21 ug ug NNP cord-005453-4057qib7 15369 22 / / SYM cord-005453-4057qib7 15369 23 l l NN cord-005453-4057qib7 15369 24 ( ( -LRB- cord-005453-4057qib7 15369 25 123 123 CD cord-005453-4057qib7 15369 26 - - SYM cord-005453-4057qib7 15369 27 1853 1853 CD cord-005453-4057qib7 15369 28 ) ) -RRB- cord-005453-4057qib7 15369 29 in in IN cord-005453-4057qib7 15369 30 G1 G1 NNP cord-005453-4057qib7 15369 31 and and CC cord-005453-4057qib7 15369 32 G2 G2 NNP cord-005453-4057qib7 15369 33 respectively respectively RB cord-005453-4057qib7 15369 34 With with IN cord-005453-4057qib7 15369 35 a a DT cord-005453-4057qib7 15369 36 median median JJ cord-005453-4057qib7 15369 37 follow follow NN cord-005453-4057qib7 15369 38 - - HYPH cord-005453-4057qib7 15369 39 up up NN cord-005453-4057qib7 15369 40 of of IN cord-005453-4057qib7 15369 41 34 34 CD cord-005453-4057qib7 15369 42 months month NNS cord-005453-4057qib7 15369 43 , , , cord-005453-4057qib7 15369 44 ( ( -LRB- cord-005453-4057qib7 15369 45 12 12 CD cord-005453-4057qib7 15369 46 - - SYM cord-005453-4057qib7 15369 47 68 68 CD cord-005453-4057qib7 15369 48 ) ) -RRB- cord-005453-4057qib7 15369 49 , , , cord-005453-4057qib7 15369 50 disease disease NN cord-005453-4057qib7 15369 51 relapse relapse NN cord-005453-4057qib7 15369 52 incidence incidence NN cord-005453-4057qib7 15369 53 was be VBD cord-005453-4057qib7 15369 54 higher high JJR cord-005453-4057qib7 15369 55 in in IN cord-005453-4057qib7 15369 56 patients patient NNS cord-005453-4057qib7 15369 57 who who WP cord-005453-4057qib7 15369 58 did do VBD cord-005453-4057qib7 15369 59 not not RB cord-005453-4057qib7 15369 60 received receive VBD cord-005453-4057qib7 15369 61 iron iron NN cord-005453-4057qib7 15369 62 chelation chelation NN cord-005453-4057qib7 15369 63 treatment treatment NN cord-005453-4057qib7 15369 64 ( ( -LRB- cord-005453-4057qib7 15369 65 G1 g1 NN cord-005453-4057qib7 15369 66 : : : cord-005453-4057qib7 15369 67 39.8 39.8 CD cord-005453-4057qib7 15369 68 % % NN cord-005453-4057qib7 15369 69 ) ) -RRB- cord-005453-4057qib7 15369 70 versus versus IN cord-005453-4057qib7 15369 71 those those DT cord-005453-4057qib7 15369 72 who who WP cord-005453-4057qib7 15369 73 received receive VBD cord-005453-4057qib7 15369 74 oral oral JJ cord-005453-4057qib7 15369 75 deferasirox deferasirox NN cord-005453-4057qib7 15369 76 ( ( -LRB- cord-005453-4057qib7 15369 77 G2:15.6 g2:15.6 NN cord-005453-4057qib7 15369 78 % % NN cord-005453-4057qib7 15369 79 ) ) -RRB- cord-005453-4057qib7 15370 1 ( ( -LRB- cord-005453-4057qib7 15370 2 Figure figure NN cord-005453-4057qib7 15370 3 1 1 CD cord-005453-4057qib7 15370 4 ) ) -RRB- cord-005453-4057qib7 15370 5 , , , cord-005453-4057qib7 15370 6 but but CC cord-005453-4057qib7 15370 7 the the DT cord-005453-4057qib7 15370 8 difference difference NN cord-005453-4057qib7 15370 9 was be VBD cord-005453-4057qib7 15370 10 not not RB cord-005453-4057qib7 15370 11 statistically statistically RB cord-005453-4057qib7 15370 12 significant significant JJ cord-005453-4057qib7 15370 13 Conclusions conclusion NNS cord-005453-4057qib7 15370 14 : : : cord-005453-4057qib7 15371 1 These these DT cord-005453-4057qib7 15371 2 results result NNS cord-005453-4057qib7 15371 3 deserve deserve VBP cord-005453-4057qib7 15371 4 more more JJR cord-005453-4057qib7 15371 5 investigation investigation NN cord-005453-4057qib7 15371 6 CHOEP CHOEP NNP cord-005453-4057qib7 15371 7 ( ( -LRB- cord-005453-4057qib7 15371 8 n=5 n=5 NNP cord-005453-4057qib7 15371 9 ) ) -RRB- cord-005453-4057qib7 15371 10 , , , cord-005453-4057qib7 15371 11 and and CC cord-005453-4057qib7 15371 12 1patient 1patient CD cord-005453-4057qib7 15371 13 received receive VBD cord-005453-4057qib7 15371 14 VTD VTD NNP cord-005453-4057qib7 15371 15 - - HYPH cord-005453-4057qib7 15371 16 PACE pace NN cord-005453-4057qib7 15371 17 10 10 CD cord-005453-4057qib7 15372 1 μg μg NNP cord-005453-4057qib7 15373 1 /kg /kg NFP cord-005453-4057qib7 15373 2 depending depend VBG cord-005453-4057qib7 15373 3 on on IN cord-005453-4057qib7 15373 4 the the DT cord-005453-4057qib7 15373 5 protocol protocol NN cord-005453-4057qib7 15373 6 . . . cord-005453-4057qib7 15374 1 The the DT cord-005453-4057qib7 15374 2 aim aim NN cord-005453-4057qib7 15374 3 was be VBD cord-005453-4057qib7 15374 4 to to TO cord-005453-4057qib7 15374 5 collect collect VB cord-005453-4057qib7 15374 6 at at IN cord-005453-4057qib7 15374 7 least least JJS cord-005453-4057qib7 15374 8 2x10 2x10 CD cord-005453-4057qib7 15374 9 6 6 CD cord-005453-4057qib7 15374 10 CD34(+ CD34(+ NNS cord-005453-4057qib7 15374 11 ) ) -RRB- cord-005453-4057qib7 15374 12 cells cell NNS cord-005453-4057qib7 15374 13 / / SYM cord-005453-4057qib7 15374 14 kg kg NN cord-005453-4057qib7 15374 15 body body NN cord-005453-4057qib7 15374 16 weight weight NN cord-005453-4057qib7 15374 17 . . . cord-005453-4057qib7 15375 1 Results result NNS cord-005453-4057qib7 15375 2 : : : cord-005453-4057qib7 15376 1 Forty forty CD cord-005453-4057qib7 15376 2 patients patient NNS cord-005453-4057qib7 15377 1 All all DT cord-005453-4057qib7 15377 2 patients patient NNS cord-005453-4057qib7 15377 3 were be VBD cord-005453-4057qib7 15377 4 stage stage NN cord-005453-4057qib7 15377 5 III III NNP cord-005453-4057qib7 15377 6 and and CC cord-005453-4057qib7 15377 7 IV IV NNP cord-005453-4057qib7 15377 8 at at IN cord-005453-4057qib7 15377 9 diagnosis diagnosis NN cord-005453-4057qib7 15377 10 . . . cord-005453-4057qib7 15378 1 29 29 CD cord-005453-4057qib7 15378 2 of of IN cord-005453-4057qib7 15378 3 the the DT cord-005453-4057qib7 15378 4 patients patient NNS cord-005453-4057qib7 15378 5 were be VBD cord-005453-4057qib7 15378 6 mobilized mobilize VBN cord-005453-4057qib7 15378 7 after after IN cord-005453-4057qib7 15378 8 one one CD cord-005453-4057qib7 15378 9 line line NN cord-005453-4057qib7 15378 10 of of IN cord-005453-4057qib7 15378 11 treatment treatment NN cord-005453-4057qib7 15378 12 , , , cord-005453-4057qib7 15378 13 six six CD cord-005453-4057qib7 15378 14 after after IN cord-005453-4057qib7 15378 15 two two CD cord-005453-4057qib7 15378 16 lines line NNS cord-005453-4057qib7 15378 17 of of IN cord-005453-4057qib7 15378 18 treatment treatment NN cord-005453-4057qib7 15378 19 and and CC cord-005453-4057qib7 15378 20 five five CD cord-005453-4057qib7 15378 21 after after IN cord-005453-4057qib7 15378 22 3 3 CD cord-005453-4057qib7 15378 23 and and CC cord-005453-4057qib7 15378 24 more more JJR cord-005453-4057qib7 15378 25 lines line NNS cord-005453-4057qib7 15378 26 of of IN cord-005453-4057qib7 15378 27 treatment treatment NN cord-005453-4057qib7 15378 28 Alexandra Alexandra NNP cord-005453-4057qib7 15378 29 Martínez Martínez NNP cord-005453-4057qib7 15378 30 - - HYPH cord-005453-4057qib7 15378 31 Roca Roca NNP cord-005453-4057qib7 15378 32 1 1 CD cord-005453-4057qib7 15378 33 , , , cord-005453-4057qib7 15378 34 Gerardo Gerardo NNP cord-005453-4057qib7 15378 35 Rodriguez Rodriguez NNP cord-005453-4057qib7 15378 36 - - HYPH cord-005453-4057qib7 15378 37 Lobato Lobato NNP cord-005453-4057qib7 15378 38 1 1 CD cord-005453-4057qib7 15378 39 , , , cord-005453-4057qib7 15378 40 Gonzalo Gonzalo NNP cord-005453-4057qib7 15378 41 Gutierrez Gutierrez NNP cord-005453-4057qib7 15378 42 - - HYPH cord-005453-4057qib7 15378 43 Garcia Garcia NNP cord-005453-4057qib7 15378 44 1,2 1,2 CD cord-005453-4057qib7 15378 45 , , , cord-005453-4057qib7 15378 46 Maria Maria NNP cord-005453-4057qib7 15378 47 Suárez Suárez NNP cord-005453-4057qib7 15378 48 - - HYPH cord-005453-4057qib7 15378 49 Lledó Lledó NNP cord-005453-4057qib7 15378 50 1 1 CD cord-005453-4057qib7 15378 51 _SP cord-005453-4057qib7 15378 52 Background background NN cord-005453-4057qib7 15378 53 : : : cord-005453-4057qib7 15378 54 Hematopoietic hematopoietic JJ cord-005453-4057qib7 15378 55 stem stem NN cord-005453-4057qib7 15378 56 cell cell NN cord-005453-4057qib7 15378 57 transplantation transplantation NN cord-005453-4057qib7 15378 58 ( ( -LRB- cord-005453-4057qib7 15378 59 HSCT HSCT NNP cord-005453-4057qib7 15378 60 ) ) -RRB- cord-005453-4057qib7 15378 61 is be VBZ cord-005453-4057qib7 15378 62 an an DT cord-005453-4057qib7 15378 63 established establish VBN cord-005453-4057qib7 15378 64 procedure procedure NN cord-005453-4057qib7 15378 65 in in IN cord-005453-4057qib7 15378 66 lymphoma lymphoma NN cord-005453-4057qib7 15378 67 Background background NN cord-005453-4057qib7 15378 68 : : : cord-005453-4057qib7 15379 1 The the DT cord-005453-4057qib7 15379 2 role role NN cord-005453-4057qib7 15379 3 of of IN cord-005453-4057qib7 15379 4 inflammatory inflammatory JJ cord-005453-4057qib7 15379 5 cascade cascade NN cord-005453-4057qib7 15379 6 in in IN cord-005453-4057qib7 15379 7 tumor tumor NN cord-005453-4057qib7 15379 8 microenvironment microenvironment NN cord-005453-4057qib7 15379 9 has have VBZ cord-005453-4057qib7 15379 10 been be VBN cord-005453-4057qib7 15379 11 demonstrated demonstrate VBN cord-005453-4057qib7 15379 12 in in IN cord-005453-4057qib7 15379 13 several several JJ cord-005453-4057qib7 15379 14 studies study NNS cord-005453-4057qib7 15379 15 . . . cord-005453-4057qib7 15380 1 As as IN cord-005453-4057qib7 15380 2 a a DT cord-005453-4057qib7 15380 3 part part NN cord-005453-4057qib7 15380 4 of of IN cord-005453-4057qib7 15380 5 this this DT cord-005453-4057qib7 15380 6 issue issue NN cord-005453-4057qib7 15380 7 , , , cord-005453-4057qib7 15380 8 elevated elevated JJ cord-005453-4057qib7 15380 9 neutrophil neutrophil NN cord-005453-4057qib7 15380 10 / / SYM cord-005453-4057qib7 15380 11 lymphocyte lymphocyte NN cord-005453-4057qib7 15380 12 ratio ratio NN cord-005453-4057qib7 15380 13 ( ( -LRB- cord-005453-4057qib7 15380 14 NLR NLR NNP cord-005453-4057qib7 15380 15 ) ) -RRB- cord-005453-4057qib7 15380 16 was be VBD cord-005453-4057qib7 15380 17 shown show VBN cord-005453-4057qib7 15380 18 to to TO cord-005453-4057qib7 15380 19 be be VB cord-005453-4057qib7 15380 20 associated associate VBN cord-005453-4057qib7 15380 21 with with IN cord-005453-4057qib7 15380 22 an an DT cord-005453-4057qib7 15380 23 adverse adverse JJ cord-005453-4057qib7 15380 24 prognosis prognosis NN cord-005453-4057qib7 15380 25 , , , cord-005453-4057qib7 15380 26 particularly particularly RB cord-005453-4057qib7 15380 27 in in IN cord-005453-4057qib7 15380 28 solid solid JJ cord-005453-4057qib7 15380 29 tumors tumor NNS cord-005453-4057qib7 15380 30 . . . cord-005453-4057qib7 15381 1 The the DT cord-005453-4057qib7 15381 2 aim aim NN cord-005453-4057qib7 15381 3 of of IN cord-005453-4057qib7 15381 4 this this DT cord-005453-4057qib7 15381 5 study study NN cord-005453-4057qib7 15381 6 is be VBZ cord-005453-4057qib7 15381 7 to to TO cord-005453-4057qib7 15381 8 determine determine VB cord-005453-4057qib7 15381 9 the the DT cord-005453-4057qib7 15381 10 impact impact NN cord-005453-4057qib7 15381 11 of of IN cord-005453-4057qib7 15381 12 pre pre JJ cord-005453-4057qib7 15381 13 - - JJ cord-005453-4057qib7 15381 14 transplant transplant NN cord-005453-4057qib7 15381 15 NLR NLR NNP cord-005453-4057qib7 15381 16 on on IN cord-005453-4057qib7 15381 17 early early JJ cord-005453-4057qib7 15381 18 transplant transplant NN cord-005453-4057qib7 15381 19 complications complication NNS cord-005453-4057qib7 15381 20 , , , cord-005453-4057qib7 15381 21 as as RB cord-005453-4057qib7 15381 22 well well RB cord-005453-4057qib7 15381 23 as as IN cord-005453-4057qib7 15381 24 post post JJ cord-005453-4057qib7 15381 25 - - JJ cord-005453-4057qib7 15381 26 transplant transplant JJ cord-005453-4057qib7 15381 27 relapse relapse NN cord-005453-4057qib7 15381 28 and and CC cord-005453-4057qib7 15381 29 survival survival NN cord-005453-4057qib7 15381 30 . . . cord-005453-4057qib7 15382 1 Methods method NNS cord-005453-4057qib7 15382 2 : : : cord-005453-4057qib7 15382 3 A a DT cord-005453-4057qib7 15382 4 total total NN cord-005453-4057qib7 15382 5 of of IN cord-005453-4057qib7 15382 6 119 119 CD cord-005453-4057qib7 15382 7 lymphoma lymphoma NN cord-005453-4057qib7 15382 8 patients patient NNS cord-005453-4057qib7 15382 9 [ [ -LRB- cord-005453-4057qib7 15382 10 median median NN cord-005453-4057qib7 15382 11 age age NN cord-005453-4057qib7 15382 12 : : : cord-005453-4057qib7 15382 13 49(18 49(18 CD cord-005453-4057qib7 15382 14 - - SYM cord-005453-4057qib7 15382 15 71 71 CD cord-005453-4057qib7 15382 16 ) ) -RRB- cord-005453-4057qib7 15382 17 years year NNS cord-005453-4057qib7 15382 18 ; ; : cord-005453-4057qib7 15382 19 male male JJ cord-005453-4057qib7 15382 20 / / SYM cord-005453-4057qib7 15382 21 female female NN cord-005453-4057qib7 15382 22 : : : cord-005453-4057qib7 15382 23 64/55 64/55 LS cord-005453-4057qib7 15382 24 ] ] -RRB- cord-005453-4057qib7 15382 25 who who WP cord-005453-4057qib7 15382 26 underwent undergo VBD cord-005453-4057qib7 15382 27 autologous autologous JJ cord-005453-4057qib7 15382 28 hematopoietic hematopoietic JJ cord-005453-4057qib7 15382 29 stem stem NN cord-005453-4057qib7 15382 30 cell cell NN cord-005453-4057qib7 15382 31 transplantation transplantation NN cord-005453-4057qib7 15382 32 ( ( -LRB- cord-005453-4057qib7 15382 33 HSCT HSCT NNP cord-005453-4057qib7 15382 34 ) ) -RRB- cord-005453-4057qib7 15382 35 were be VBD cord-005453-4057qib7 15382 36 included include VBN cord-005453-4057qib7 15382 37 in in IN cord-005453-4057qib7 15382 38 this this DT cord-005453-4057qib7 15382 39 retrospective retrospective JJ cord-005453-4057qib7 15382 40 study study NN cord-005453-4057qib7 15382 41 . . . cord-005453-4057qib7 15383 1 Results result NNS cord-005453-4057qib7 15383 2 : : : cord-005453-4057qib7 15384 1 The the DT cord-005453-4057qib7 15384 2 initial initial JJ cord-005453-4057qib7 15384 3 diagnosis diagnosis NN cord-005453-4057qib7 15384 4 was be VBD cord-005453-4057qib7 15384 5 Hodgkin Hodgkin NNP cord-005453-4057qib7 15384 6 lymphoma lymphoma NN cord-005453-4057qib7 15384 7 ( ( -LRB- cord-005453-4057qib7 15384 8 HL HL NNP cord-005453-4057qib7 15384 9 ) ) -RRB- cord-005453-4057qib7 15384 10 in in IN cord-005453-4057qib7 15384 11 35 35 CD cord-005453-4057qib7 15384 12 ( ( -LRB- cord-005453-4057qib7 15384 13 29.4 29.4 CD cord-005453-4057qib7 15384 14 % % NN cord-005453-4057qib7 15384 15 ) ) -RRB- cord-005453-4057qib7 15384 16 , , , cord-005453-4057qib7 15384 17 B b NN cord-005453-4057qib7 15384 18 - - HYPH cord-005453-4057qib7 15384 19 cell cell NN cord-005453-4057qib7 15384 20 non non JJ cord-005453-4057qib7 15384 21 - - JJ cord-005453-4057qib7 15384 22 Hodgkin hodgkin JJ cord-005453-4057qib7 15384 23 lymphoma lymphoma NN cord-005453-4057qib7 15384 24 ( ( -LRB- cord-005453-4057qib7 15384 25 NHL NHL NNP cord-005453-4057qib7 15384 26 ) ) -RRB- cord-005453-4057qib7 15384 27 in in IN cord-005453-4057qib7 15384 28 67 67 CD cord-005453-4057qib7 15384 29 ( ( -LRB- cord-005453-4057qib7 15384 30 56.3 56.3 CD cord-005453-4057qib7 15384 31 % % NN cord-005453-4057qib7 15384 32 ) ) -RRB- cord-005453-4057qib7 15384 33 and and CC cord-005453-4057qib7 15384 34 T t NN cord-005453-4057qib7 15384 35 - - HYPH cord-005453-4057qib7 15384 36 cell cell NN cord-005453-4057qib7 15384 37 NHL NHL NNP cord-005453-4057qib7 15384 38 in in IN cord-005453-4057qib7 15384 39 17 17 CD cord-005453-4057qib7 15384 40 ( ( -LRB- cord-005453-4057qib7 15384 41 14.3 14.3 CD cord-005453-4057qib7 15384 42 % % NN cord-005453-4057qib7 15384 43 ) ) -RRB- cord-005453-4057qib7 15384 44 patients patient NNS cord-005453-4057qib7 15384 45 . . . cord-005453-4057qib7 15385 1 Of of IN cord-005453-4057qib7 15385 2 116 116 CD cord-005453-4057qib7 15385 3 patients patient NNS cord-005453-4057qib7 15385 4 who who WP cord-005453-4057qib7 15385 5 were be VBD cord-005453-4057qib7 15385 6 evaluated evaluate VBN cord-005453-4057qib7 15385 7 for for IN cord-005453-4057qib7 15385 8 pretransplant pretransplant JJ cord-005453-4057qib7 15385 9 disease disease NN cord-005453-4057qib7 15385 10 status status NN cord-005453-4057qib7 15385 11 , , , cord-005453-4057qib7 15385 12 52 52 CD cord-005453-4057qib7 15385 13 patients patient NNS cord-005453-4057qib7 15385 14 ( ( -LRB- cord-005453-4057qib7 15385 15 44.8 44.8 CD cord-005453-4057qib7 15385 16 % % NN cord-005453-4057qib7 15385 17 ) ) -RRB- cord-005453-4057qib7 15385 18 were be VBD cord-005453-4057qib7 15385 19 in in IN cord-005453-4057qib7 15385 20 complete complete JJ cord-005453-4057qib7 15385 21 remission remission NN cord-005453-4057qib7 15385 22 , , , cord-005453-4057qib7 15385 23 45 45 CD cord-005453-4057qib7 15385 24 patients patient NNS cord-005453-4057qib7 15385 25 ( ( -LRB- cord-005453-4057qib7 15385 26 38.8 38.8 CD cord-005453-4057qib7 15385 27 % % NN cord-005453-4057qib7 15385 28 ) ) -RRB- cord-005453-4057qib7 15385 29 were be VBD cord-005453-4057qib7 15385 30 in in IN cord-005453-4057qib7 15385 31 partial partial JJ cord-005453-4057qib7 15385 32 remission remission NN cord-005453-4057qib7 15385 33 and and CC cord-005453-4057qib7 15385 34 19 19 CD cord-005453-4057qib7 15385 35 ( ( -LRB- cord-005453-4057qib7 15385 36 16.4 16.4 CD cord-005453-4057qib7 15385 37 % % NN cord-005453-4057qib7 15385 38 ) ) -RRB- cord-005453-4057qib7 15385 39 patients patient NNS cord-005453-4057qib7 15385 40 had have VBD cord-005453-4057qib7 15385 41 refractory refractory JJ cord-005453-4057qib7 15385 42 disease disease NN cord-005453-4057qib7 15385 43 . . . cord-005453-4057qib7 15386 1 Median median JJ cord-005453-4057qib7 15386 2 pre pre JJ cord-005453-4057qib7 15386 3 - - JJ cord-005453-4057qib7 15386 4 transplant transplant NN cord-005453-4057qib7 15386 5 NLR NLR NNP cord-005453-4057qib7 15386 6 was be VBD cord-005453-4057qib7 15386 7 found find VBN cord-005453-4057qib7 15386 8 to to TO cord-005453-4057qib7 15386 9 be be VB cord-005453-4057qib7 15386 10 3.42(0 3.42(0 CD cord-005453-4057qib7 15386 11 - - SYM cord-005453-4057qib7 15386 12 97 97 CD cord-005453-4057qib7 15386 13 ) ) -RRB- cord-005453-4057qib7 15386 14 . . . cord-005453-4057qib7 15387 1 When when WRB cord-005453-4057qib7 15387 2 the the DT cord-005453-4057qib7 15387 3 study study NN cord-005453-4057qib7 15387 4 population population NN cord-005453-4057qib7 15387 5 was be VBD cord-005453-4057qib7 15387 6 divided divide VBN cord-005453-4057qib7 15387 7 into into IN cord-005453-4057qib7 15387 8 two two CD cord-005453-4057qib7 15387 9 subgroups subgroup NNS cord-005453-4057qib7 15387 10 as as IN cord-005453-4057qib7 15387 11 " " `` cord-005453-4057qib7 15387 12 low- low- NN cord-005453-4057qib7 15387 13 " " '' cord-005453-4057qib7 15387 14 and and CC cord-005453-4057qib7 15387 15 " " `` cord-005453-4057qib7 15387 16 high high JJ cord-005453-4057qib7 15387 17 - - HYPH cord-005453-4057qib7 15387 18 NLR NLR NNP cord-005453-4057qib7 15387 19 " " '' cord-005453-4057qib7 15387 20 , , , cord-005453-4057qib7 15387 21 based base VBN cord-005453-4057qib7 15387 22 on on IN cord-005453-4057qib7 15387 23 median median JJ cord-005453-4057qib7 15387 24 NLR NLR NNP cord-005453-4057qib7 15387 25 value value NN cord-005453-4057qib7 15387 26 , , , cord-005453-4057qib7 15387 27 number number NN cord-005453-4057qib7 15387 28 of of IN cord-005453-4057qib7 15387 29 febrile febrile JJ cord-005453-4057qib7 15387 30 days day NNS cord-005453-4057qib7 15387 31 were be VBD cord-005453-4057qib7 15387 32 found find VBN cord-005453-4057qib7 15387 33 to to TO cord-005453-4057qib7 15387 34 be be VB cord-005453-4057qib7 15387 35 relatively relatively RB cord-005453-4057qib7 15387 36 higher high JJR cord-005453-4057qib7 15387 37 in in IN cord-005453-4057qib7 15387 38 the the DT cord-005453-4057qib7 15387 39 low low JJ cord-005453-4057qib7 15387 40 - - HYPH cord-005453-4057qib7 15387 41 NLR NLR NNP cord-005453-4057qib7 15387 42 group group NN cord-005453-4057qib7 15387 43 ( ( -LRB- cord-005453-4057qib7 15387 44 p=0.051 p=0.051 NNP cord-005453-4057qib7 15387 45 ) ) -RRB- cord-005453-4057qib7 15387 46 . . . cord-005453-4057qib7 15388 1 A a DT cord-005453-4057qib7 15388 2 positive positive JJ cord-005453-4057qib7 15388 3 correlation correlation NN cord-005453-4057qib7 15388 4 was be VBD cord-005453-4057qib7 15388 5 demonstrated demonstrate VBN cord-005453-4057qib7 15388 6 between between IN cord-005453-4057qib7 15388 7 NLR NLR NNP cord-005453-4057qib7 15388 8 and and CC cord-005453-4057qib7 15388 9 lactate lactate NN cord-005453-4057qib7 15388 10 dehydrogenase dehydrogenase NN cord-005453-4057qib7 15388 11 levels level NNS cord-005453-4057qib7 15388 12 ( ( -LRB- cord-005453-4057qib7 15388 13 r=0.218 r=0.218 NNS cord-005453-4057qib7 15388 14 ; ; : cord-005453-4057qib7 15388 15 p=0.03 p=0.03 NN cord-005453-4057qib7 15388 16 ) ) -RRB- cord-005453-4057qib7 15388 17 ; ; : cord-005453-4057qib7 15388 18 and and CC cord-005453-4057qib7 15388 19 NLR NLR NNP cord-005453-4057qib7 15388 20 and and CC cord-005453-4057qib7 15388 21 ferritin ferritin NN cord-005453-4057qib7 15388 22 levels level NNS cord-005453-4057qib7 15388 23 ( ( -LRB- cord-005453-4057qib7 15388 24 r=0.277 r=0.277 NNP cord-005453-4057qib7 15388 25 ; ; : cord-005453-4057qib7 15388 26 p=0.003 p=0.003 NNP cord-005453-4057qib7 15388 27 ) ) -RRB- cord-005453-4057qib7 15388 28 . . . cord-005453-4057qib7 15389 1 At at IN cord-005453-4057qib7 15389 2 a a DT cord-005453-4057qib7 15389 3 median median JJ cord-005453-4057qib7 15389 4 follow follow NN cord-005453-4057qib7 15389 5 - - HYPH cord-005453-4057qib7 15389 6 up up NN cord-005453-4057qib7 15389 7 of of IN cord-005453-4057qib7 15389 8 24 24 CD cord-005453-4057qib7 15389 9 ( ( -LRB- cord-005453-4057qib7 15389 10 1 1 CD cord-005453-4057qib7 15389 11 - - SYM cord-005453-4057qib7 15389 12 264 264 CD cord-005453-4057qib7 15389 13 ) ) -RRB- cord-005453-4057qib7 15389 14 months month NNS cord-005453-4057qib7 15389 15 , , , cord-005453-4057qib7 15389 16 overall overall JJ cord-005453-4057qib7 15389 17 survival survival NN cord-005453-4057qib7 15389 18 ( ( -LRB- cord-005453-4057qib7 15389 19 OS OS NNP cord-005453-4057qib7 15389 20 ) ) -RRB- cord-005453-4057qib7 15389 21 was be VBD cord-005453-4057qib7 15389 22 found find VBN cord-005453-4057qib7 15389 23 to to TO cord-005453-4057qib7 15389 24 be be VB cord-005453-4057qib7 15389 25 better well JJR cord-005453-4057qib7 15389 26 in in IN cord-005453-4057qib7 15389 27 the the DT cord-005453-4057qib7 15389 28 low low JJ cord-005453-4057qib7 15389 29 - - HYPH cord-005453-4057qib7 15389 30 NLR NLR NNP cord-005453-4057qib7 15389 31 group group NN cord-005453-4057qib7 15389 32 without without IN cord-005453-4057qib7 15389 33 statistical statistical JJ cord-005453-4057qib7 15389 34 significance significance NN cord-005453-4057qib7 15389 35 [ [ -LRB- cord-005453-4057qib7 15389 36 25 25 CD cord-005453-4057qib7 15389 37 vs vs IN cord-005453-4057qib7 15389 38 13(1 13(1 CD cord-005453-4057qib7 15389 39 - - SYM cord-005453-4057qib7 15389 40 91 91 CD cord-005453-4057qib7 15389 41 ) ) -RRB- cord-005453-4057qib7 15389 42 months month NNS cord-005453-4057qib7 15389 43 ; ; : cord-005453-4057qib7 15389 44 p=0.069 p=0.069 NNP cord-005453-4057qib7 15389 45 ] ] -RRB- cord-005453-4057qib7 15389 46 . . . cord-005453-4057qib7 15390 1 In in IN cord-005453-4057qib7 15390 2 univariate univariate JJ cord-005453-4057qib7 15390 3 analysis analysis NN cord-005453-4057qib7 15390 4 , , , cord-005453-4057qib7 15390 5 pre pre JJ cord-005453-4057qib7 15390 6 - - JJ cord-005453-4057qib7 15390 7 transplant transplant NN cord-005453-4057qib7 15390 8 NLR NLR NNP cord-005453-4057qib7 15390 9 represented represent VBD cord-005453-4057qib7 15390 10 a a DT cord-005453-4057qib7 15390 11 significant significant JJ cord-005453-4057qib7 15390 12 impact impact NN cord-005453-4057qib7 15390 13 on on IN cord-005453-4057qib7 15390 14 OS OS NNP cord-005453-4057qib7 15390 15 ( ( -LRB- cord-005453-4057qib7 15390 16 p=0.021 p=0.021 NNP cord-005453-4057qib7 15390 17 ) ) -RRB- cord-005453-4057qib7 15390 18 . . . cord-005453-4057qib7 15391 1 Other other JJ cord-005453-4057qib7 15391 2 prognostic prognostic JJ cord-005453-4057qib7 15391 3 factors factor NNS cord-005453-4057qib7 15391 4 were be VBD cord-005453-4057qib7 15391 5 age age NN cord-005453-4057qib7 15391 6 ( ( -LRB- cord-005453-4057qib7 15391 7 p=0.041 p=0.041 NNP cord-005453-4057qib7 15391 8 ) ) -RRB- cord-005453-4057qib7 15391 9 , , , cord-005453-4057qib7 15391 10 platelet platelet NN cord-005453-4057qib7 15391 11 engraftment engraftment NN cord-005453-4057qib7 15391 12 ( ( -LRB- cord-005453-4057qib7 15391 13 p=0.018 p=0.018 NNP cord-005453-4057qib7 15391 14 ) ) -RRB- cord-005453-4057qib7 15391 15 , , , cord-005453-4057qib7 15391 16 post post JJ cord-005453-4057qib7 15391 17 - - JJ cord-005453-4057qib7 15391 18 transplant transplant JJ cord-005453-4057qib7 15391 19 relapse relapse NN cord-005453-4057qib7 15391 20 ( ( -LRB- cord-005453-4057qib7 15391 21 p=0.009 p=0.009 NN cord-005453-4057qib7 15391 22 ) ) -RRB- cord-005453-4057qib7 15391 23 and and CC cord-005453-4057qib7 15391 24 pre pre JJ cord-005453-4057qib7 15391 25 - - JJ cord-005453-4057qib7 15391 26 transplant transplant JJ cord-005453-4057qib7 15391 27 ferritin ferritin NN cord-005453-4057qib7 15391 28 level level NN cord-005453-4057qib7 15391 29 ( ( -LRB- cord-005453-4057qib7 15391 30 p p NN cord-005453-4057qib7 15391 31 < < XX cord-005453-4057qib7 15391 32 0.001 0.001 CD cord-005453-4057qib7 15391 33 ) ) -RRB- cord-005453-4057qib7 15391 34 . . . cord-005453-4057qib7 15392 1 The the DT cord-005453-4057qib7 15392 2 permanent permanent JJ cord-005453-4057qib7 15392 3 impact impact NN cord-005453-4057qib7 15392 4 of of IN cord-005453-4057qib7 15392 5 ferritin ferritin NN cord-005453-4057qib7 15392 6 on on IN cord-005453-4057qib7 15392 7 OS OS NNP cord-005453-4057qib7 15392 8 was be VBD cord-005453-4057qib7 15392 9 confirmed confirm VBN cord-005453-4057qib7 15392 10 in in IN cord-005453-4057qib7 15392 11 multivariate multivariate JJ cord-005453-4057qib7 15392 12 analysis analysis NN cord-005453-4057qib7 15392 13 ( ( -LRB- cord-005453-4057qib7 15392 14 p=0.008).Conclusions p=0.008).Conclusions NNP cord-005453-4057qib7 15392 15 : : : cord-005453-4057qib7 15393 1 In in IN cord-005453-4057qib7 15393 2 this this DT cord-005453-4057qib7 15393 3 study study NN cord-005453-4057qib7 15393 4 , , , cord-005453-4057qib7 15393 5 an an DT cord-005453-4057qib7 15393 6 adverse adverse JJ cord-005453-4057qib7 15393 7 impact impact NN cord-005453-4057qib7 15393 8 of of IN cord-005453-4057qib7 15393 9 elevated elevated JJ cord-005453-4057qib7 15393 10 pre pre JJ cord-005453-4057qib7 15393 11 - - JJ cord-005453-4057qib7 15393 12 transplant transplant NN cord-005453-4057qib7 15393 13 NLR NLR NNP cord-005453-4057qib7 15393 14 on on IN cord-005453-4057qib7 15393 15 OS OS NNP cord-005453-4057qib7 15393 16 was be VBD cord-005453-4057qib7 15393 17 demonstrated demonstrate VBN cord-005453-4057qib7 15393 18 in in IN cord-005453-4057qib7 15393 19 autologous autologous JJ cord-005453-4057qib7 15393 20 HSCT HSCT NNP cord-005453-4057qib7 15393 21 recipients recipient NNS cord-005453-4057qib7 15393 22 with with IN cord-005453-4057qib7 15393 23 lymphoma lymphoma NN cord-005453-4057qib7 15393 24 . . . cord-005453-4057qib7 15394 1 As as IN cord-005453-4057qib7 15394 2 a a DT cord-005453-4057qib7 15394 3 predictor predictor NN cord-005453-4057qib7 15394 4 of of IN cord-005453-4057qib7 15394 5 prognosis prognosis NN cord-005453-4057qib7 15394 6 , , , cord-005453-4057qib7 15394 7 NLR NLR NNP cord-005453-4057qib7 15394 8 may may MD cord-005453-4057qib7 15394 9 be be VB cord-005453-4057qib7 15394 10 considered consider VBN cord-005453-4057qib7 15394 11 as as IN cord-005453-4057qib7 15394 12 a a DT cord-005453-4057qib7 15394 13 safe safe JJ cord-005453-4057qib7 15394 14 and and CC cord-005453-4057qib7 15394 15 cost cost NN cord-005453-4057qib7 15394 16 - - HYPH cord-005453-4057qib7 15394 17 effective effective JJ cord-005453-4057qib7 15394 18 parameter parameter NN cord-005453-4057qib7 15394 19 . . . cord-005453-4057qib7 15395 1 Further further JJ cord-005453-4057qib7 15395 2 studies study NNS cord-005453-4057qib7 15395 3 are be VBP cord-005453-4057qib7 15395 4 required require VBN cord-005453-4057qib7 15395 5 in in IN cord-005453-4057qib7 15395 6 order order NN cord-005453-4057qib7 15395 7 to to TO cord-005453-4057qib7 15395 8 use use VB cord-005453-4057qib7 15395 9 this this DT cord-005453-4057qib7 15395 10 predictor predictor NN cord-005453-4057qib7 15395 11 in in IN cord-005453-4057qib7 15395 12 routine routine JJ cord-005453-4057qib7 15395 13 clinical clinical JJ cord-005453-4057qib7 15395 14 practice practice NN cord-005453-4057qib7 15395 15 . . . cord-005453-4057qib7 15396 1 Background background NN cord-005453-4057qib7 15396 2 : : : cord-005453-4057qib7 15397 1 High high JJ cord-005453-4057qib7 15397 2 cure cure NN cord-005453-4057qib7 15397 3 rates rate NNS cord-005453-4057qib7 15397 4 in in IN cord-005453-4057qib7 15397 5 childhood childhood NN cord-005453-4057qib7 15397 6 diseases disease NNS cord-005453-4057qib7 15397 7 have have VBP cord-005453-4057qib7 15397 8 been be VBN cord-005453-4057qib7 15397 9 achieved achieve VBN cord-005453-4057qib7 15397 10 by by IN cord-005453-4057qib7 15397 11 stem stem NN cord-005453-4057qib7 15397 12 cell cell NN cord-005453-4057qib7 15397 13 transplantation transplantation NN cord-005453-4057qib7 15397 14 ( ( -LRB- cord-005453-4057qib7 15397 15 SCT SCT NNP cord-005453-4057qib7 15397 16 ) ) -RRB- cord-005453-4057qib7 15397 17 . . . cord-005453-4057qib7 15398 1 However however RB cord-005453-4057qib7 15398 2 , , , cord-005453-4057qib7 15398 3 there there EX cord-005453-4057qib7 15398 4 is be VBZ cord-005453-4057qib7 15398 5 little little JJ cord-005453-4057qib7 15398 6 knowledge knowledge NN cord-005453-4057qib7 15398 7 concerning concern VBG cord-005453-4057qib7 15398 8 recovery recovery NN cord-005453-4057qib7 15398 9 of of IN cord-005453-4057qib7 15398 10 the the DT cord-005453-4057qib7 15398 11 immune immune JJ cord-005453-4057qib7 15398 12 system system NN cord-005453-4057qib7 15398 13 and and CC cord-005453-4057qib7 15398 14 community community NN cord-005453-4057qib7 15398 15 - - HYPH cord-005453-4057qib7 15398 16 acquired acquire VBN cord-005453-4057qib7 15398 17 infection infection NN cord-005453-4057qib7 15398 18 after after IN cord-005453-4057qib7 15398 19 SCT SCT NNP cord-005453-4057qib7 15398 20 . . . cord-005453-4057qib7 15399 1 Here here RB cord-005453-4057qib7 15399 2 we -PRON- PRP cord-005453-4057qib7 15399 3 studied study VBD cord-005453-4057qib7 15399 4 the the DT cord-005453-4057qib7 15399 5 long long JJ cord-005453-4057qib7 15399 6 - - HYPH cord-005453-4057qib7 15399 7 term term NN cord-005453-4057qib7 15399 8 reconstitution reconstitution NN cord-005453-4057qib7 15399 9 of of IN cord-005453-4057qib7 15399 10 the the DT cord-005453-4057qib7 15399 11 immune immune JJ cord-005453-4057qib7 15399 12 system system NN cord-005453-4057qib7 15399 13 and and CC cord-005453-4057qib7 15399 14 incidences incidence NNS cord-005453-4057qib7 15399 15 of of IN cord-005453-4057qib7 15399 16 community community NN cord-005453-4057qib7 15399 17 - - HYPH cord-005453-4057qib7 15399 18 acquired acquire VBN cord-005453-4057qib7 15399 19 infection infection NN cord-005453-4057qib7 15399 20 after after IN cord-005453-4057qib7 15399 21 SCT.Methods sct.method NNS cord-005453-4057qib7 15399 22 : : : cord-005453-4057qib7 15400 1 We -PRON- PRP cord-005453-4057qib7 15400 2 reviewed review VBD cord-005453-4057qib7 15400 3 medical medical JJ cord-005453-4057qib7 15400 4 records record NNS cord-005453-4057qib7 15400 5 for for IN cord-005453-4057qib7 15400 6 44 44 CD cord-005453-4057qib7 15400 7 patients patient NNS cord-005453-4057qib7 15400 8 ( ( -LRB- cord-005453-4057qib7 15400 9 M M NNP cord-005453-4057qib7 15400 10 / / SYM cord-005453-4057qib7 15400 11 F F NNP cord-005453-4057qib7 15400 12 : : : cord-005453-4057qib7 15400 13 31/13 31/13 CD cord-005453-4057qib7 15400 14 , , , cord-005453-4057qib7 15400 15 median median JJ cord-005453-4057qib7 15400 16 age age NN cord-005453-4057qib7 15400 17 : : : cord-005453-4057qib7 15400 18 5 5 CD cord-005453-4057qib7 15400 19 years year NNS cord-005453-4057qib7 15400 20 ( ( -LRB- cord-005453-4057qib7 15400 21 range range NN cord-005453-4057qib7 15400 22 : : : cord-005453-4057qib7 15400 23 1 1 CD cord-005453-4057qib7 15400 24 - - HYPH cord-005453-4057qib7 15400 25 22years 22years NNP cord-005453-4057qib7 15400 26 ) ) -RRB- cord-005453-4057qib7 15400 27 who who WP cord-005453-4057qib7 15400 28 were be VBD cord-005453-4057qib7 15400 29 treated treat VBN cord-005453-4057qib7 15400 30 in in IN cord-005453-4057qib7 15400 31 the the DT cord-005453-4057qib7 15400 32 Department Department NNP cord-005453-4057qib7 15400 33 of of IN cord-005453-4057qib7 15400 34 Pediatrics Pediatrics NNP cord-005453-4057qib7 15400 35 , , , cord-005453-4057qib7 15400 36 Hokkaido Hokkaido NNP cord-005453-4057qib7 15400 37 University University NNP cord-005453-4057qib7 15400 38 Hospital Hospital NNP cord-005453-4057qib7 15400 39 . . . cord-005453-4057qib7 15401 1 We -PRON- PRP cord-005453-4057qib7 15401 2 analyzed analyze VBD cord-005453-4057qib7 15401 3 CD4-positive cd4-positive JJ cord-005453-4057qib7 15401 4 cell cell NN cord-005453-4057qib7 15401 5 counts count NNS cord-005453-4057qib7 15401 6 , , , cord-005453-4057qib7 15401 7 serum serum NN cord-005453-4057qib7 15401 8 immunoglobulin immunoglobulin NN cord-005453-4057qib7 15401 9 G G NNP cord-005453-4057qib7 15401 10 ( ( -LRB- cord-005453-4057qib7 15401 11 IgG IgG NNP cord-005453-4057qib7 15401 12 ) ) -RRB- cord-005453-4057qib7 15401 13 levels level NNS cord-005453-4057qib7 15401 14 , , , cord-005453-4057qib7 15401 15 and and CC cord-005453-4057qib7 15401 16 incidences incidence NNS cord-005453-4057qib7 15401 17 of of IN cord-005453-4057qib7 15401 18 community community NN cord-005453-4057qib7 15401 19 - - HYPH cord-005453-4057qib7 15401 20 acquired acquire VBN cord-005453-4057qib7 15401 21 infection infection NN cord-005453-4057qib7 15401 22 until until IN cord-005453-4057qib7 15401 23 2 2 CD cord-005453-4057qib7 15401 24 years year NNS cord-005453-4057qib7 15401 25 after after IN cord-005453-4057qib7 15401 26 SCT SCT NNP cord-005453-4057qib7 15401 27 . . . cord-005453-4057qib7 15402 1 Indications indication NNS cord-005453-4057qib7 15402 2 for for IN cord-005453-4057qib7 15402 3 SCT SCT NNP cord-005453-4057qib7 15402 4 were be VBD cord-005453-4057qib7 15402 5 ALL all DT cord-005453-4057qib7 15402 6 in in IN cord-005453-4057qib7 15402 7 8 8 CD cord-005453-4057qib7 15402 8 patients patient NNS cord-005453-4057qib7 15402 9 , , , cord-005453-4057qib7 15402 10 AML AML NNP cord-005453-4057qib7 15402 11 in in IN cord-005453-4057qib7 15402 12 4 4 CD cord-005453-4057qib7 15402 13 , , , cord-005453-4057qib7 15402 14 AA AA NNP cord-005453-4057qib7 15402 15 in in IN cord-005453-4057qib7 15402 16 6 6 CD cord-005453-4057qib7 15403 1 , , , cord-005453-4057qib7 15403 2 NB NB NNP cord-005453-4057qib7 15403 3 in in IN cord-005453-4057qib7 15403 4 5 5 CD cord-005453-4057qib7 15403 5 , , , cord-005453-4057qib7 15403 6 RMS RMS NNP cord-005453-4057qib7 15403 7 in in IN cord-005453-4057qib7 15403 8 2 2 CD cord-005453-4057qib7 15403 9 , , , cord-005453-4057qib7 15403 10 JMML JMML NNP cord-005453-4057qib7 15403 11 in in IN cord-005453-4057qib7 15403 12 1 1 CD cord-005453-4057qib7 15403 13 , , , cord-005453-4057qib7 15403 14 NHL NHL NNP cord-005453-4057qib7 15403 15 in in IN cord-005453-4057qib7 15403 16 1 1 CD cord-005453-4057qib7 15403 17 , , , cord-005453-4057qib7 15403 18 CGD CGD NNP cord-005453-4057qib7 15403 19 in in IN cord-005453-4057qib7 15403 20 5 5 CD cord-005453-4057qib7 15403 21 , , , cord-005453-4057qib7 15403 22 WAS be VBD cord-005453-4057qib7 15403 23 in in IN cord-005453-4057qib7 15403 24 3 3 CD cord-005453-4057qib7 15403 25 , , , cord-005453-4057qib7 15403 26 XSCID XSCID NNP cord-005453-4057qib7 15403 27 in in IN cord-005453-4057qib7 15403 28 2 2 CD cord-005453-4057qib7 15403 29 , , , cord-005453-4057qib7 15403 30 APDS APDS NNP cord-005453-4057qib7 15403 31 in in IN cord-005453-4057qib7 15403 32 2 2 CD cord-005453-4057qib7 15403 33 , , , cord-005453-4057qib7 15404 1 CD40LD CD40LD NNP cord-005453-4057qib7 15404 2 in in IN cord-005453-4057qib7 15404 3 2 2 CD cord-005453-4057qib7 15404 4 , , , cord-005453-4057qib7 15404 5 and and CC cord-005453-4057qib7 15404 6 other other JJ cord-005453-4057qib7 15404 7 solid solid JJ cord-005453-4057qib7 15404 8 tumor tumor NN cord-005453-4057qib7 15404 9 in in IN cord-005453-4057qib7 15404 10 3 3 CD cord-005453-4057qib7 15404 11 patients patient NNS cord-005453-4057qib7 15404 12 . . . cord-005453-4057qib7 15405 1 Stem stem JJ cord-005453-4057qib7 15405 2 cell cell NN cord-005453-4057qib7 15405 3 sources source NNS cord-005453-4057qib7 15405 4 were be VBD cord-005453-4057qib7 15405 5 autologous autologous JJ cord-005453-4057qib7 15405 6 PB PB NNP cord-005453-4057qib7 15405 7 / / SYM cord-005453-4057qib7 15405 8 BM BM NNP cord-005453-4057qib7 15405 9 in in IN cord-005453-4057qib7 15405 10 6 6 CD cord-005453-4057qib7 15405 11 , , , cord-005453-4057qib7 15405 12 allogenic allogenic JJ cord-005453-4057qib7 15405 13 BM bm NN cord-005453-4057qib7 15405 14 in in IN cord-005453-4057qib7 15405 15 23 23 CD cord-005453-4057qib7 15405 16 ( ( -LRB- cord-005453-4057qib7 15405 17 9 9 CD cord-005453-4057qib7 15405 18 related related JJ cord-005453-4057qib7 15405 19 and and CC cord-005453-4057qib7 15405 20 14 14 CD cord-005453-4057qib7 15405 21 unrelated unrelated JJ cord-005453-4057qib7 15405 22 ) ) -RRB- cord-005453-4057qib7 15405 23 and and CC cord-005453-4057qib7 15405 24 allogenic allogenic JJ cord-005453-4057qib7 15405 25 CB CB NNP cord-005453-4057qib7 15405 26 in in IN cord-005453-4057qib7 15405 27 15 15 CD cord-005453-4057qib7 15405 28 patients patient NNS cord-005453-4057qib7 15405 29 . . . cord-005453-4057qib7 15406 1 In in IN cord-005453-4057qib7 15406 2 this this DT cord-005453-4057qib7 15406 3 study study NN cord-005453-4057qib7 15406 4 , , , cord-005453-4057qib7 15406 5 we -PRON- PRP cord-005453-4057qib7 15406 6 excluded exclude VBD cord-005453-4057qib7 15406 7 patients patient NNS cord-005453-4057qib7 15406 8 who who WP cord-005453-4057qib7 15406 9 relapsed relapse VBD cord-005453-4057qib7 15406 10 after after IN cord-005453-4057qib7 15406 11 SCT.Results SCT.Results NNP cord-005453-4057qib7 15406 12 : : : cord-005453-4057qib7 15407 1 The the DT cord-005453-4057qib7 15407 2 duration duration NN cord-005453-4057qib7 15407 3 of of IN cord-005453-4057qib7 15407 4 CD4-positive cd4-positive JJ cord-005453-4057qib7 15407 5 cell cell NN cord-005453-4057qib7 15407 6 counts count VBZ cord-005453-4057qib7 15407 7 < < XX cord-005453-4057qib7 15407 8 500/ 500/ NNP cord-005453-4057qib7 15407 9 ml ml NN cord-005453-4057qib7 15407 10 after after IN cord-005453-4057qib7 15407 11 SCT SCT NNP cord-005453-4057qib7 15407 12 was be VBD cord-005453-4057qib7 15407 13 14.7±11.4 14.7±11.4 CD cord-005453-4057qib7 15407 14 months month NNS cord-005453-4057qib7 15407 15 in in IN cord-005453-4057qib7 15407 16 all all DT cord-005453-4057qib7 15407 17 patients patient NNS cord-005453-4057qib7 15407 18 . . . cord-005453-4057qib7 15408 1 The the DT cord-005453-4057qib7 15408 2 durations duration NNS cord-005453-4057qib7 15408 3 were be VBD cord-005453-4057qib7 15408 4 12.6±7.1 12.6±7.1 CD cord-005453-4057qib7 15408 5 months month NNS cord-005453-4057qib7 15408 6 in in IN cord-005453-4057qib7 15408 7 patients patient NNS cord-005453-4057qib7 15408 8 with with IN cord-005453-4057qib7 15408 9 hematologic hematologic JJ cord-005453-4057qib7 15408 10 malignancies malignancy NNS cord-005453-4057qib7 15408 11 , , , cord-005453-4057qib7 15408 12 11.5±7.3 11.5±7.3 CD cord-005453-4057qib7 15408 13 months month NNS cord-005453-4057qib7 15408 14 in in IN cord-005453-4057qib7 15408 15 patients patient NNS cord-005453-4057qib7 15408 16 with with IN cord-005453-4057qib7 15408 17 hematologic hematologic JJ cord-005453-4057qib7 15408 18 disorders disorder NNS cord-005453-4057qib7 15408 19 such such JJ cord-005453-4057qib7 15408 20 as as IN cord-005453-4057qib7 15408 21 aplastic aplastic JJ cord-005453-4057qib7 15408 22 anemia anemia NN cord-005453-4057qib7 15408 23 and and CC cord-005453-4057qib7 15408 24 PID PID NNP cord-005453-4057qib7 15408 25 , , , cord-005453-4057qib7 15408 26 28.8±25.9 28.8±25.9 CD cord-005453-4057qib7 15408 27 months month NNS cord-005453-4057qib7 15408 28 in in IN cord-005453-4057qib7 15408 29 patients patient NNS cord-005453-4057qib7 15408 30 with with IN cord-005453-4057qib7 15408 31 solid solid JJ cord-005453-4057qib7 15408 32 tumor tumor NN cord-005453-4057qib7 15408 33 , , , cord-005453-4057qib7 15408 34 16.0 16.0 CD cord-005453-4057qib7 15408 35 ±10.4 ±10.4 CD cord-005453-4057qib7 15408 36 months month NNS cord-005453-4057qib7 15408 37 in in IN cord-005453-4057qib7 15408 38 patients patient NNS cord-005453-4057qib7 15408 39 who who WP cord-005453-4057qib7 15408 40 received receive VBD cord-005453-4057qib7 15408 41 autologous autologous JJ cord-005453-4057qib7 15408 42 SCT SCT NNP cord-005453-4057qib7 15408 43 , , , cord-005453-4057qib7 15408 44 25.1±22.2 25.1±22.2 CD cord-005453-4057qib7 15408 45 months month NNS cord-005453-4057qib7 15408 46 in in IN cord-005453-4057qib7 15408 47 patients patient NNS cord-005453-4057qib7 15408 48 who who WP cord-005453-4057qib7 15408 49 received receive VBD cord-005453-4057qib7 15408 50 related related JJ cord-005453-4057qib7 15408 51 BMT/ BMT/ NNP cord-005453-4057qib7 15408 52 PBSCT PBSCT NNP cord-005453-4057qib7 15408 53 , , , cord-005453-4057qib7 15408 54 13.8±6.7 13.8±6.7 CD cord-005453-4057qib7 15408 55 months month NNS cord-005453-4057qib7 15408 56 in in IN cord-005453-4057qib7 15408 57 patients patient NNS cord-005453-4057qib7 15408 58 who who WP cord-005453-4057qib7 15408 59 received receive VBD cord-005453-4057qib7 15408 60 unrelated unrelated JJ cord-005453-4057qib7 15408 61 BMT BMT NNP cord-005453-4057qib7 15408 62 , , , cord-005453-4057qib7 15408 63 and and CC cord-005453-4057qib7 15408 64 10.5±5.8 10.5±5.8 CD cord-005453-4057qib7 15408 65 months month NNS cord-005453-4057qib7 15408 66 in in IN cord-005453-4057qib7 15408 67 patients patient NNS cord-005453-4057qib7 15408 68 who who WP cord-005453-4057qib7 15408 69 received receive VBD cord-005453-4057qib7 15408 70 CBT CBT NNP cord-005453-4057qib7 15408 71 . . . cord-005453-4057qib7 15409 1 The the DT cord-005453-4057qib7 15409 2 durations duration NNS cord-005453-4057qib7 15409 3 of of IN cord-005453-4057qib7 15409 4 IgG IgG NNP cord-005453-4057qib7 15409 5 < < XX cord-005453-4057qib7 15409 6 500mg 500mg NNP cord-005453-4057qib7 15409 7 / / SYM cord-005453-4057qib7 15409 8 dl dl NNP cord-005453-4057qib7 15409 9 after after IN cord-005453-4057qib7 15409 10 SCT SCT NNP cord-005453-4057qib7 15409 11 were be VBD cord-005453-4057qib7 15409 12 14.9±11.5 14.9±11.5 CD cord-005453-4057qib7 15409 13 months month NNS cord-005453-4057qib7 15409 14 in in IN cord-005453-4057qib7 15409 15 all all DT cord-005453-4057qib7 15409 16 patients patient NNS cord-005453-4057qib7 15409 17 , , , cord-005453-4057qib7 15410 1 15.8±9.7 15.8±9.7 CD cord-005453-4057qib7 15410 2 months month NNS cord-005453-4057qib7 15410 3 in in IN cord-005453-4057qib7 15410 4 patients patient NNS cord-005453-4057qib7 15410 5 with with IN cord-005453-4057qib7 15410 6 hematologic hematologic JJ cord-005453-4057qib7 15410 7 malignancies malignancy NNS cord-005453-4057qib7 15410 8 , , , cord-005453-4057qib7 15410 9 11.6±5.1 11.6±5.1 CD cord-005453-4057qib7 15410 10 months month NNS cord-005453-4057qib7 15410 11 in in IN cord-005453-4057qib7 15410 12 patients patient NNS cord-005453-4057qib7 15410 13 with with IN cord-005453-4057qib7 15410 14 hematologic hematologic JJ cord-005453-4057qib7 15410 15 disorders disorder NNS cord-005453-4057qib7 15410 16 , , . cord-005453-4057qib7 15411 1 11.0±8.7 11.0±8.7 CD cord-005453-4057qib7 15411 2 months month NNS cord-005453-4057qib7 15411 3 in in IN cord-005453-4057qib7 15411 4 patients patient NNS cord-005453-4057qib7 15411 5 with with IN cord-005453-4057qib7 15411 6 solid solid JJ cord-005453-4057qib7 15411 7 tumor tumor NN cord-005453-4057qib7 15411 8 , , , cord-005453-4057qib7 15411 9 19.0±18.6 19.0±18.6 CD cord-005453-4057qib7 15411 10 months month NNS cord-005453-4057qib7 15411 11 in in IN cord-005453-4057qib7 15411 12 patients patient NNS cord-005453-4057qib7 15411 13 who who WP cord-005453-4057qib7 15411 14 received receive VBD cord-005453-4057qib7 15411 15 autologous autologous JJ cord-005453-4057qib7 15411 16 SCT SCT NNP cord-005453-4057qib7 15411 17 , , , cord-005453-4057qib7 15411 18 12.0±8.3 12.0±8.3 CD cord-005453-4057qib7 15411 19 months month NNS cord-005453-4057qib7 15411 20 in in IN cord-005453-4057qib7 15411 21 patients patient NNS cord-005453-4057qib7 15411 22 who who WP cord-005453-4057qib7 15411 23 received receive VBD cord-005453-4057qib7 15411 24 related related JJ cord-005453-4057qib7 15411 25 BMT BMT NNP cord-005453-4057qib7 15411 26 / / SYM cord-005453-4057qib7 15411 27 PBSCT PBSCT NNP cord-005453-4057qib7 15411 28 , , , cord-005453-4057qib7 15411 29 11.5±5.7 11.5±5.7 CD cord-005453-4057qib7 15411 30 months month NNS cord-005453-4057qib7 15411 31 in in IN cord-005453-4057qib7 15411 32 patients patient NNS cord-005453-4057qib7 15411 33 who who WP cord-005453-4057qib7 15411 34 received receive VBD cord-005453-4057qib7 15411 35 unrelated unrelated JJ cord-005453-4057qib7 15411 36 BMT BMT NNP cord-005453-4057qib7 15411 37 , , , cord-005453-4057qib7 15411 38 and and CC cord-005453-4057qib7 15411 39 15.9±8.7 15.9±8.7 CD cord-005453-4057qib7 15411 40 months month NNS cord-005453-4057qib7 15411 41 in in IN cord-005453-4057qib7 15411 42 patients patient NNS cord-005453-4057qib7 15411 43 who who WP cord-005453-4057qib7 15411 44 received receive VBD cord-005453-4057qib7 15411 45 CBT CBT NNP cord-005453-4057qib7 15411 46 . . . cord-005453-4057qib7 15412 1 There there EX cord-005453-4057qib7 15412 2 was be VBD cord-005453-4057qib7 15412 3 a a DT cord-005453-4057qib7 15412 4 significantly significantly RB cord-005453-4057qib7 15412 5 higher high JJR cord-005453-4057qib7 15412 6 incidence incidence NN cord-005453-4057qib7 15412 7 of of IN cord-005453-4057qib7 15412 8 community community NN cord-005453-4057qib7 15412 9 - - HYPH cord-005453-4057qib7 15412 10 acquired acquire VBN cord-005453-4057qib7 15412 11 infection infection NN cord-005453-4057qib7 15412 12 from from IN cord-005453-4057qib7 15412 13 6 6 CD cord-005453-4057qib7 15412 14 months month NNS cord-005453-4057qib7 15412 15 after after IN cord-005453-4057qib7 15412 16 SCT SCT NNP cord-005453-4057qib7 15412 17 . . . cord-005453-4057qib7 15413 1 There there EX cord-005453-4057qib7 15413 2 were be VBD cord-005453-4057qib7 15413 3 significant significant JJ cord-005453-4057qib7 15413 4 differences difference NNS cord-005453-4057qib7 15413 5 in in IN cord-005453-4057qib7 15413 6 the the DT cord-005453-4057qib7 15413 7 incidence incidence NN cord-005453-4057qib7 15413 8 of of IN cord-005453-4057qib7 15413 9 community community NN cord-005453-4057qib7 15413 10 - - HYPH cord-005453-4057qib7 15413 11 acquired acquire VBN cord-005453-4057qib7 15413 12 infections infection NNS cord-005453-4057qib7 15413 13 between between IN cord-005453-4057qib7 15413 14 patients patient NNS cord-005453-4057qib7 15413 15 with with IN cord-005453-4057qib7 15413 16 CD4-positive cd4-positive JJ cord-005453-4057qib7 15413 17 cell cell NN cord-005453-4057qib7 15413 18 counts count NNS cord-005453-4057qib7 15413 19 of of IN cord-005453-4057qib7 15413 20 < < NNP cord-005453-4057qib7 15413 21 500 500 CD cord-005453-4057qib7 15413 22 / / SYM cord-005453-4057qib7 15413 23 ml ml NN cord-005453-4057qib7 15413 24 and and CC cord-005453-4057qib7 15413 25 Background Background NNP cord-005453-4057qib7 15413 26 : : : cord-005453-4057qib7 15413 27 Allogeneic allogeneic NN cord-005453-4057qib7 15413 28 hematopoietic hematopoietic JJ cord-005453-4057qib7 15413 29 cell cell NN cord-005453-4057qib7 15413 30 transplantation transplantation NN cord-005453-4057qib7 15413 31 ( ( -LRB- cord-005453-4057qib7 15413 32 allo allo NN cord-005453-4057qib7 15413 33 - - HYPH cord-005453-4057qib7 15413 34 HCT HCT NNP cord-005453-4057qib7 15413 35 ) ) -RRB- cord-005453-4057qib7 15413 36 has have VBZ cord-005453-4057qib7 15413 37 the the DT cord-005453-4057qib7 15413 38 potential potential NN cord-005453-4057qib7 15413 39 to to TO cord-005453-4057qib7 15413 40 cure cure VB cord-005453-4057qib7 15413 41 subgroups subgroup NNS cord-005453-4057qib7 15413 42 of of IN cord-005453-4057qib7 15413 43 patients patient NNS cord-005453-4057qib7 15413 44 with with IN cord-005453-4057qib7 15413 45 multiple multiple JJ cord-005453-4057qib7 15413 46 myeloma myeloma NN cord-005453-4057qib7 15413 47 ( ( -LRB- cord-005453-4057qib7 15413 48 MM MM NNP cord-005453-4057qib7 15413 49 ) ) -RRB- cord-005453-4057qib7 15413 50 but but CC cord-005453-4057qib7 15413 51 its -PRON- PRP$ cord-005453-4057qib7 15413 52 role role NN cord-005453-4057qib7 15413 53 is be VBZ cord-005453-4057qib7 15413 54 controversial controversial JJ cord-005453-4057qib7 15413 55 due due IN cord-005453-4057qib7 15413 56 to to IN cord-005453-4057qib7 15413 57 high high JJ cord-005453-4057qib7 15413 58 transplant transplant NN cord-005453-4057qib7 15413 59 - - HYPH cord-005453-4057qib7 15413 60 related relate VBN cord-005453-4057qib7 15413 61 mortality mortality NN cord-005453-4057qib7 15413 62 . . . cord-005453-4057qib7 15414 1 While while IN cord-005453-4057qib7 15414 2 autologous autologous JJ cord-005453-4057qib7 15414 3 HCT hct NN cord-005453-4057qib7 15414 4 is be VBZ cord-005453-4057qib7 15414 5 well well RB cord-005453-4057qib7 15414 6 established establish VBN cord-005453-4057qib7 15414 7 as as IN cord-005453-4057qib7 15414 8 consolidation consolidation NN cord-005453-4057qib7 15414 9 after after IN cord-005453-4057qib7 15414 10 induction induction NN cord-005453-4057qib7 15414 11 therapy therapy NN cord-005453-4057qib7 15414 12 using use VBG cord-005453-4057qib7 15414 13 novel novel JJ cord-005453-4057qib7 15414 14 agents agent NNS cord-005453-4057qib7 15414 15 , , , cord-005453-4057qib7 15414 16 allo allo NN cord-005453-4057qib7 15414 17 - - HYPH cord-005453-4057qib7 15414 18 HCT HCT NNP cord-005453-4057qib7 15414 19 is be VBZ cord-005453-4057qib7 15414 20 still still RB cord-005453-4057qib7 15414 21 considered consider VBN cord-005453-4057qib7 15414 22 experimental experimental JJ cord-005453-4057qib7 15414 23 due due IN cord-005453-4057qib7 15414 24 to to IN cord-005453-4057qib7 15414 25 excessive excessive JJ cord-005453-4057qib7 15414 26 early early JJ cord-005453-4057qib7 15414 27 toxicity toxicity NN cord-005453-4057qib7 15414 28 . . . cord-005453-4057qib7 15415 1 Methods method NNS cord-005453-4057qib7 15415 2 : : : cord-005453-4057qib7 15415 3 We -PRON- PRP cord-005453-4057qib7 15415 4 retrospectively retrospectively RB cord-005453-4057qib7 15415 5 studied study VBD cord-005453-4057qib7 15415 6 45 45 CD cord-005453-4057qib7 15415 7 MM MM NNP cord-005453-4057qib7 15415 8 patients patient NNS cord-005453-4057qib7 15415 9 ( ( -LRB- cord-005453-4057qib7 15415 10 pts pts NNP cord-005453-4057qib7 15415 11 ) ) -RRB- cord-005453-4057qib7 15415 12 ; ; . cord-005453-4057qib7 15416 1 25 25 CD cord-005453-4057qib7 15416 2 ( ( -LRB- cord-005453-4057qib7 15416 3 55,6 55,6 CD cord-005453-4057qib7 15416 4 % % NN cord-005453-4057qib7 15416 5 ) ) -RRB- cord-005453-4057qib7 15416 6 were be VBD cord-005453-4057qib7 15416 7 males male NNS cord-005453-4057qib7 15416 8 with with IN cord-005453-4057qib7 15416 9 a a DT cord-005453-4057qib7 15416 10 median median JJ cord-005453-4057qib7 15416 11 age age NN cord-005453-4057qib7 15416 12 of of IN cord-005453-4057qib7 15416 13 52 52 CD cord-005453-4057qib7 15416 14 years year NNS cord-005453-4057qib7 15417 1 ( ( -LRB- cord-005453-4057qib7 15417 2 range range NN cord-005453-4057qib7 15417 3 : : : cord-005453-4057qib7 15417 4 32 32 CD cord-005453-4057qib7 15417 5 - - SYM cord-005453-4057qib7 15417 6 60 60 CD cord-005453-4057qib7 15417 7 ) ) -RRB- cord-005453-4057qib7 15417 8 , , , cord-005453-4057qib7 15417 9 who who WP cord-005453-4057qib7 15417 10 underwent undergo VBD cord-005453-4057qib7 15417 11 allo allo NN cord-005453-4057qib7 15417 12 - - HYPH cord-005453-4057qib7 15417 13 HSCT HSCT NNP cord-005453-4057qib7 15417 14 in in IN cord-005453-4057qib7 15417 15 our -PRON- PRP$ cord-005453-4057qib7 15417 16 center center NN cord-005453-4057qib7 15417 17 between between IN cord-005453-4057qib7 15417 18 2007 2007 CD cord-005453-4057qib7 15417 19 and and CC cord-005453-4057qib7 15417 20 2018.Median 2018.median CD cord-005453-4057qib7 15417 21 time time NN cord-005453-4057qib7 15417 22 between between IN cord-005453-4057qib7 15417 23 diagnosis diagnosis NN cord-005453-4057qib7 15417 24 and and CC cord-005453-4057qib7 15417 25 allo allo NN cord-005453-4057qib7 15417 26 - - HYPH cord-005453-4057qib7 15417 27 HCT HCT NNP cord-005453-4057qib7 15417 28 was be VBD cord-005453-4057qib7 15417 29 40 40 CD cord-005453-4057qib7 15417 30 months month NNS cord-005453-4057qib7 15418 1 ( ( -LRB- cord-005453-4057qib7 15418 2 range range NN cord-005453-4057qib7 15418 3 : : : cord-005453-4057qib7 15418 4 20 20 CD cord-005453-4057qib7 15418 5 - - SYM cord-005453-4057qib7 15418 6 143).Results 143).results CD cord-005453-4057qib7 15418 7 : : : cord-005453-4057qib7 15419 1 The the DT cord-005453-4057qib7 15419 2 International International NNP cord-005453-4057qib7 15419 3 Staging Staging NNP cord-005453-4057qib7 15419 4 System System NNP cord-005453-4057qib7 15419 5 ( ( -LRB- cord-005453-4057qib7 15419 6 ISS ISS NNP cord-005453-4057qib7 15419 7 ) ) -RRB- cord-005453-4057qib7 15419 8 was be VBD cord-005453-4057qib7 15419 9 ISS ISS NNP cord-005453-4057qib7 15420 1 I -PRON- PRP cord-005453-4057qib7 15420 2 ( ( -LRB- cord-005453-4057qib7 15420 3 33,3 33,3 CD cord-005453-4057qib7 15420 4 % % NN cord-005453-4057qib7 15420 5 ) ) -RRB- cord-005453-4057qib7 15420 6 , , , cord-005453-4057qib7 15420 7 ISS ISS NNP cord-005453-4057qib7 15420 8 II II NNP cord-005453-4057qib7 15420 9 ( ( -LRB- cord-005453-4057qib7 15420 10 28,9 28,9 CD cord-005453-4057qib7 15420 11 % % NN cord-005453-4057qib7 15420 12 ) ) -RRB- cord-005453-4057qib7 15420 13 , , , cord-005453-4057qib7 15420 14 and and CC cord-005453-4057qib7 15420 15 ISS ISS NNP cord-005453-4057qib7 15420 16 III III NNP cord-005453-4057qib7 15420 17 ( ( -LRB- cord-005453-4057qib7 15420 18 37,8 37,8 CD cord-005453-4057qib7 15420 19 % % NN cord-005453-4057qib7 15420 20 ) ) -RRB- cord-005453-4057qib7 15420 21 . . . cord-005453-4057qib7 15421 1 Twentyeight twentyeight JJ cord-005453-4057qib7 15421 2 ( ( -LRB- cord-005453-4057qib7 15421 3 62,2 62,2 CD cord-005453-4057qib7 15421 4 % % NN cord-005453-4057qib7 15421 5 ) ) -RRB- cord-005453-4057qib7 15421 6 pts pt NNS cord-005453-4057qib7 15421 7 received receive VBD cord-005453-4057qib7 15421 8 cells cell NNS cord-005453-4057qib7 15421 9 from from IN cord-005453-4057qib7 15421 10 unrelated unrelated JJ cord-005453-4057qib7 15421 11 donor donor NN cord-005453-4057qib7 15421 12 and and CC cord-005453-4057qib7 15421 13 17 17 CD cord-005453-4057qib7 15421 14 pts pt NNS cord-005453-4057qib7 15421 15 from from IN cord-005453-4057qib7 15421 16 identical identical JJ cord-005453-4057qib7 15421 17 siblings sibling NNS cord-005453-4057qib7 15421 18 . . . cord-005453-4057qib7 15422 1 Stem stem JJ cord-005453-4057qib7 15422 2 cell cell NN cord-005453-4057qib7 15422 3 source source NN cord-005453-4057qib7 15422 4 were be VBD cord-005453-4057qib7 15422 5 : : : cord-005453-4057qib7 15422 6 peripheral peripheral JJ cord-005453-4057qib7 15422 7 blood blood NN cord-005453-4057qib7 15422 8 ( ( -LRB- cord-005453-4057qib7 15422 9 n=25 n=25 NNP cord-005453-4057qib7 15422 10 ) ) -RRB- cord-005453-4057qib7 15422 11 and and CC cord-005453-4057qib7 15422 12 bone bone NN cord-005453-4057qib7 15422 13 marrow marrow NN cord-005453-4057qib7 15422 14 ( ( -LRB- cord-005453-4057qib7 15422 15 n=20 n=20 NNP cord-005453-4057qib7 15422 16 ) ) -RRB- cord-005453-4057qib7 15422 17 . . . cord-005453-4057qib7 15423 1 Grouprisk grouprisk NN cord-005453-4057qib7 15423 2 distribution distribution NN cord-005453-4057qib7 15423 3 using use VBG cord-005453-4057qib7 15423 4 HCT HCT NNP cord-005453-4057qib7 15423 5 - - HYPH cord-005453-4057qib7 15423 6 CI CI NNP cord-005453-4057qib7 15423 7 and and CC cord-005453-4057qib7 15423 8 PAM PAM NNP cord-005453-4057qib7 15423 9 index index NN cord-005453-4057qib7 15423 10 can can MD cord-005453-4057qib7 15423 11 be be VB cord-005453-4057qib7 15423 12 seen see VBN cord-005453-4057qib7 15423 13 in in IN cord-005453-4057qib7 15423 14 figure figure NN cord-005453-4057qib7 15423 15 1 1 CD cord-005453-4057qib7 15423 16 . . . cord-005453-4057qib7 15424 1 Response response NN cord-005453-4057qib7 15424 2 was be VBD cord-005453-4057qib7 15424 3 evaluated evaluate VBN cord-005453-4057qib7 15424 4 at at IN cord-005453-4057qib7 15424 5 day day NN cord-005453-4057qib7 15424 6 +100 +100 NNS cord-005453-4057qib7 15424 7 : : : cord-005453-4057qib7 15424 8 CR CR NNP cord-005453-4057qib7 15424 9 ( ( -LRB- cord-005453-4057qib7 15424 10 53,3 53,3 CD cord-005453-4057qib7 15424 11 % % NN cord-005453-4057qib7 15424 12 ) ) -RRB- cord-005453-4057qib7 15424 13 , , , cord-005453-4057qib7 15424 14 VGPR VGPR NNP cord-005453-4057qib7 15424 15 ( ( -LRB- cord-005453-4057qib7 15424 16 11,1 11,1 CD cord-005453-4057qib7 15424 17 % % NN cord-005453-4057qib7 15424 18 ) ) -RRB- cord-005453-4057qib7 15424 19 , , , cord-005453-4057qib7 15424 20 PR PR NNP cord-005453-4057qib7 15424 21 ( ( -LRB- cord-005453-4057qib7 15424 22 22,2 22,2 CD cord-005453-4057qib7 15424 23 % % NN cord-005453-4057qib7 15424 24 ) ) -RRB- cord-005453-4057qib7 15424 25 and and CC cord-005453-4057qib7 15424 26 SD sd NN cord-005453-4057qib7 15424 27 ( ( -LRB- cord-005453-4057qib7 15424 28 2,2 2,2 CD cord-005453-4057qib7 15424 29 % % NN cord-005453-4057qib7 15424 30 ) ) -RRB- cord-005453-4057qib7 15424 31 ; ; : cord-005453-4057qib7 15424 32 response response NN cord-005453-4057qib7 15424 33 was be VBD cord-005453-4057qib7 15424 34 not not RB cord-005453-4057qib7 15424 35 evaluated evaluate VBN cord-005453-4057qib7 15424 36 in in IN cord-005453-4057qib7 15424 37 5 5 CD cord-005453-4057qib7 15424 38 pts pt NNS cord-005453-4057qib7 15424 39 . . . cord-005453-4057qib7 15425 1 Regarding regard VBG cord-005453-4057qib7 15425 2 hospitalization hospitalization NN cord-005453-4057qib7 15425 3 , , , cord-005453-4057qib7 15425 4 11 11 CD cord-005453-4057qib7 15425 5 ( ( -LRB- cord-005453-4057qib7 15425 6 24,4 24,4 CD cord-005453-4057qib7 15425 7 % % NN cord-005453-4057qib7 15425 8 ) ) -RRB- cord-005453-4057qib7 15425 9 pts pts NN cord-005453-4057qib7 15425 10 and and CC cord-005453-4057qib7 15425 11 22 22 CD cord-005453-4057qib7 15425 12 ( ( -LRB- cord-005453-4057qib7 15425 13 48,9 48,9 CD cord-005453-4057qib7 15425 14 % % NN cord-005453-4057qib7 15425 15 ) ) -RRB- cord-005453-4057qib7 15425 16 pts pt NNS cord-005453-4057qib7 15425 17 needed need VBN cord-005453-4057qib7 15425 18 readmission readmission NN cord-005453-4057qib7 15425 19 in in IN cord-005453-4057qib7 15425 20 the the DT cord-005453-4057qib7 15425 21 first first JJ cord-005453-4057qib7 15425 22 100 100 CD cord-005453-4057qib7 15425 23 days day NNS cord-005453-4057qib7 15425 24 and and CC cord-005453-4057qib7 15425 25 365 365 CD cord-005453-4057qib7 15425 26 days day NNS cord-005453-4057qib7 15425 27 post post NN cord-005453-4057qib7 15425 28 - - JJ cord-005453-4057qib7 15425 29 alloHCT allohct JJ cord-005453-4057qib7 15425 30 , , , cord-005453-4057qib7 15425 31 respectively respectively RB cord-005453-4057qib7 15425 32 , , , cord-005453-4057qib7 15425 33 and and CC cord-005453-4057qib7 15425 34 median median JJ cord-005453-4057qib7 15425 35 days day NNS cord-005453-4057qib7 15425 36 of of IN cord-005453-4057qib7 15425 37 hospitalization hospitalization NN cord-005453-4057qib7 15425 38 was be VBD cord-005453-4057qib7 15425 39 27 27 CD cord-005453-4057qib7 15425 40 days day NNS cord-005453-4057qib7 15426 1 ( ( -LRB- cord-005453-4057qib7 15426 2 range range NN cord-005453-4057qib7 15426 3 : : : cord-005453-4057qib7 15426 4 4 4 CD cord-005453-4057qib7 15426 5 - - SYM cord-005453-4057qib7 15426 6 92 92 CD cord-005453-4057qib7 15426 7 ) ) -RRB- cord-005453-4057qib7 15426 8 . . . cord-005453-4057qib7 15427 1 Reasons reason NNS cord-005453-4057qib7 15427 2 for for IN cord-005453-4057qib7 15427 3 first first JJ cord-005453-4057qib7 15427 4 re re NN cord-005453-4057qib7 15427 5 - - NN cord-005453-4057qib7 15427 6 admission admission NN cord-005453-4057qib7 15427 7 were be VBD cord-005453-4057qib7 15427 8 : : : cord-005453-4057qib7 15427 9 infection infection NN cord-005453-4057qib7 15427 10 ( ( -LRB- cord-005453-4057qib7 15427 11 68,2 68,2 CD cord-005453-4057qib7 15427 12 % % NN cord-005453-4057qib7 15427 13 ) ) -RRB- cord-005453-4057qib7 15427 14 , , , cord-005453-4057qib7 15427 15 GvHD GvHD NNP cord-005453-4057qib7 15427 16 ( ( -LRB- cord-005453-4057qib7 15427 17 27,3 27,3 CD cord-005453-4057qib7 15427 18 % % NN cord-005453-4057qib7 15427 19 ) ) -RRB- cord-005453-4057qib7 15427 20 and and CC cord-005453-4057qib7 15427 21 renal renal JJ cord-005453-4057qib7 15427 22 insufficiency insufficiency NN cord-005453-4057qib7 15427 23 ( ( -LRB- cord-005453-4057qib7 15427 24 4,5 4,5 CD cord-005453-4057qib7 15427 25 % % NN cord-005453-4057qib7 15427 26 ) ) -RRB- cord-005453-4057qib7 15427 27 . . . cord-005453-4057qib7 15428 1 Twenty twenty CD cord-005453-4057qib7 15428 2 - - HYPH cord-005453-4057qib7 15428 3 seven seven CD cord-005453-4057qib7 15428 4 ( ( -LRB- cord-005453-4057qib7 15428 5 60 60 CD cord-005453-4057qib7 15428 6 % % NN cord-005453-4057qib7 15428 7 ) ) -RRB- cord-005453-4057qib7 15428 8 died die VBD cord-005453-4057qib7 15428 9 and and CC cord-005453-4057qib7 15428 10 death death NN cord-005453-4057qib7 15428 11 causes cause NNS cord-005453-4057qib7 15428 12 were be VBD cord-005453-4057qib7 15428 13 : : : cord-005453-4057qib7 15428 14 infection infection NN cord-005453-4057qib7 15428 15 ( ( -LRB- cord-005453-4057qib7 15428 16 35,6 35,6 CD cord-005453-4057qib7 15428 17 % % NN cord-005453-4057qib7 15428 18 ) ) -RRB- cord-005453-4057qib7 15428 19 , , , cord-005453-4057qib7 15428 20 progression progression NN cord-005453-4057qib7 15428 21 ( ( -LRB- cord-005453-4057qib7 15428 22 15,6 15,6 CD cord-005453-4057qib7 15428 23 % % NN cord-005453-4057qib7 15428 24 ) ) -RRB- cord-005453-4057qib7 15428 25 , , , cord-005453-4057qib7 15428 26 secondary secondary JJ cord-005453-4057qib7 15428 27 tumor tumor NN cord-005453-4057qib7 15428 28 ( ( -LRB- cord-005453-4057qib7 15428 29 4,4 4,4 CD cord-005453-4057qib7 15428 30 % % NN cord-005453-4057qib7 15428 31 ) ) -RRB- cord-005453-4057qib7 15428 32 and and CC cord-005453-4057qib7 15428 33 the the DT cord-005453-4057qib7 15428 34 remainder remainder NN cord-005453-4057qib7 15428 35 , , , cord-005453-4057qib7 15428 36 GvHD gvhd NN cord-005453-4057qib7 15428 37 and and CC cord-005453-4057qib7 15428 38 intracranial intracranial JJ cord-005453-4057qib7 15428 39 hemorrhage hemorrhage NN cord-005453-4057qib7 15428 40 . . . cord-005453-4057qib7 15429 1 In in IN cord-005453-4057qib7 15429 2 addition addition NN cord-005453-4057qib7 15429 3 , , , cord-005453-4057qib7 15429 4 26 26 CD cord-005453-4057qib7 15429 5 pts pt NNS cord-005453-4057qib7 15429 6 ( ( -LRB- cord-005453-4057qib7 15429 7 57,8 57,8 CD cord-005453-4057qib7 15429 8 % % NN cord-005453-4057qib7 15429 9 ) ) -RRB- cord-005453-4057qib7 15429 10 suffered suffer VBN cord-005453-4057qib7 15429 11 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 15429 12 ( ( -LRB- cord-005453-4057qib7 15429 13 CMV CMV NNP cord-005453-4057qib7 15429 14 ) ) -RRB- cord-005453-4057qib7 15429 15 reactivation reactivation NN cord-005453-4057qib7 15429 16 . . . cord-005453-4057qib7 15430 1 Median median JJ cord-005453-4057qib7 15430 2 overall overall JJ cord-005453-4057qib7 15430 3 survival survival NN cord-005453-4057qib7 15430 4 ( ( -LRB- cord-005453-4057qib7 15430 5 OS OS NNP cord-005453-4057qib7 15430 6 ) ) -RRB- cord-005453-4057qib7 15430 7 was be VBD cord-005453-4057qib7 15430 8 44 44 CD cord-005453-4057qib7 15430 9 months month NNS cord-005453-4057qib7 15431 1 ( ( -LRB- cord-005453-4057qib7 15431 2 range range NN cord-005453-4057qib7 15431 3 : : : cord-005453-4057qib7 15431 4 11 11 CD cord-005453-4057qib7 15431 5 - - SYM cord-005453-4057qib7 15431 6 76 76 CD cord-005453-4057qib7 15431 7 ) ) -RRB- cord-005453-4057qib7 15431 8 . . . cord-005453-4057qib7 15432 1 Univariate Univariate NNP cord-005453-4057qib7 15432 2 analysis analysis NN cord-005453-4057qib7 15432 3 showed show VBD cord-005453-4057qib7 15432 4 that that IN cord-005453-4057qib7 15432 5 re re NN cord-005453-4057qib7 15432 6 - - NN cord-005453-4057qib7 15432 7 admission admission NN cord-005453-4057qib7 15432 8 in in IN cord-005453-4057qib7 15432 9 first first JJ cord-005453-4057qib7 15432 10 100 100 CD cord-005453-4057qib7 15432 11 days day NNS cord-005453-4057qib7 15432 12 ( ( -LRB- cord-005453-4057qib7 15432 13 HR HR NNP cord-005453-4057qib7 15432 14 4 4 CD cord-005453-4057qib7 15432 15 , , , cord-005453-4057qib7 15432 16 19 19 CD cord-005453-4057qib7 15432 17 ; ; : cord-005453-4057qib7 15432 18 p=0 p=0 NNP cord-005453-4057qib7 15432 19 , , , cord-005453-4057qib7 15432 20 001 001 CD cord-005453-4057qib7 15432 21 ) ) -RRB- cord-005453-4057qib7 15432 22 , , , cord-005453-4057qib7 15432 23 re re NN cord-005453-4057qib7 15432 24 - - NN cord-005453-4057qib7 15432 25 admission admission NN cord-005453-4057qib7 15432 26 in in IN cord-005453-4057qib7 15432 27 first first JJ cord-005453-4057qib7 15432 28 365 365 CD cord-005453-4057qib7 15432 29 days day NNS cord-005453-4057qib7 15432 30 ( ( -LRB- cord-005453-4057qib7 15432 31 HR HR NNP cord-005453-4057qib7 15432 32 3 3 CD cord-005453-4057qib7 15432 33 , , , cord-005453-4057qib7 15432 34 6 6 CD cord-005453-4057qib7 15432 35 ; ; : cord-005453-4057qib7 15432 36 p=0 p=0 NNP cord-005453-4057qib7 15432 37 , , , cord-005453-4057qib7 15432 38 001 001 CD cord-005453-4057qib7 15432 39 ) ) -RRB- cord-005453-4057qib7 15432 40 , , , cord-005453-4057qib7 15432 41 CMV CMV NNP cord-005453-4057qib7 15432 42 reactivation reactivation NN cord-005453-4057qib7 15432 43 ( ( -LRB- cord-005453-4057qib7 15432 44 HR HR NNP cord-005453-4057qib7 15432 45 2,38 2,38 CD cord-005453-4057qib7 15432 46 ; ; : cord-005453-4057qib7 15432 47 p=0,038 p=0,038 NNP cord-005453-4057qib7 15432 48 ) ) -RRB- cord-005453-4057qib7 15432 49 , , , cord-005453-4057qib7 15432 50 ISS ISS NNP cord-005453-4057qib7 15432 51 ( ( -LRB- cord-005453-4057qib7 15432 52 ISS ISS NNP cord-005453-4057qib7 15432 53 - - HYPH cord-005453-4057qib7 15432 54 I I NNP cord-005453-4057qib7 15432 55 vs vs IN cord-005453-4057qib7 15432 56 ISS ISS NNP cord-005453-4057qib7 15432 57 - - HYPH cord-005453-4057qib7 15432 58 II II NNP cord-005453-4057qib7 15432 59 and and CC cord-005453-4057qib7 15432 60 III III NNP cord-005453-4057qib7 15432 61 ; ; : cord-005453-4057qib7 15432 62 HR HR NNP cord-005453-4057qib7 15432 63 0,347 0,347 CD cord-005453-4057qib7 15432 64 ; ; : cord-005453-4057qib7 15432 65 p=0,033 p=0,033 NNP cord-005453-4057qib7 15432 66 ) ) -RRB- cord-005453-4057qib7 15432 67 , , , cord-005453-4057qib7 15432 68 days day NNS cord-005453-4057qib7 15432 69 of of IN cord-005453-4057qib7 15432 70 hospitalization hospitalization NN cord-005453-4057qib7 15432 71 in in IN cord-005453-4057qib7 15432 72 the the DT cord-005453-4057qib7 15432 73 first first JJ cord-005453-4057qib7 15432 74 100 100 CD cord-005453-4057qib7 15432 75 days day NNS cord-005453-4057qib7 15432 76 and and CC cord-005453-4057qib7 15432 77 response response NN cord-005453-4057qib7 15432 78 at at IN cord-005453-4057qib7 15432 79 +100 +100 NNP cord-005453-4057qib7 15432 80 day day NN cord-005453-4057qib7 15432 81 ( ( -LRB- cord-005453-4057qib7 15432 82 CR CR NNP cord-005453-4057qib7 15432 83 plus plus CC cord-005453-4057qib7 15432 84 VGPR VGPR NNP cord-005453-4057qib7 15432 85 vs vs IN cord-005453-4057qib7 15432 86 the the DT cord-005453-4057qib7 15432 87 remainder remainder NN cord-005453-4057qib7 15432 88 ; ; : cord-005453-4057qib7 15432 89 HR HR NNP cord-005453-4057qib7 15432 90 0,143 0,143 CD cord-005453-4057qib7 15432 91 ; ; : cord-005453-4057qib7 15432 92 p=0,04 p=0,04 NNP cord-005453-4057qib7 15432 93 ) ) -RRB- cord-005453-4057qib7 15432 94 were be VBD cord-005453-4057qib7 15432 95 predictor predictor NN cord-005453-4057qib7 15432 96 factors factor NNS cord-005453-4057qib7 15432 97 for for IN cord-005453-4057qib7 15432 98 OS OS NNP cord-005453-4057qib7 15432 99 . . . cord-005453-4057qib7 15433 1 Other other JJ cord-005453-4057qib7 15433 2 factors factor NNS cord-005453-4057qib7 15433 3 like like IN cord-005453-4057qib7 15433 4 karyotype karyotype NN cord-005453-4057qib7 15433 5 , , , cord-005453-4057qib7 15433 6 response response NN cord-005453-4057qib7 15433 7 before before IN cord-005453-4057qib7 15433 8 allo allo NN cord-005453-4057qib7 15433 9 - - HYPH cord-005453-4057qib7 15433 10 HCT HCT NNP cord-005453-4057qib7 15433 11 , , , cord-005453-4057qib7 15433 12 HLA HLA NNP cord-005453-4057qib7 15433 13 - - HYPH cord-005453-4057qib7 15433 14 mismatch mismatch NN cord-005453-4057qib7 15433 15 or or CC cord-005453-4057qib7 15433 16 baseline baseline JJ cord-005453-4057qib7 15433 17 CMV CMV NNP cord-005453-4057qib7 15433 18 serostatus serostatus NN cord-005453-4057qib7 15433 19 , , , cord-005453-4057qib7 15433 20 among among IN cord-005453-4057qib7 15433 21 others other NNS cord-005453-4057qib7 15433 22 , , , cord-005453-4057qib7 15433 23 do do VBP cord-005453-4057qib7 15433 24 not not RB cord-005453-4057qib7 15433 25 impact impact VB cord-005453-4057qib7 15433 26 on on IN cord-005453-4057qib7 15433 27 OS.Median os.median JJ cord-005453-4057qib7 15433 28 OS OS NNP cord-005453-4057qib7 15433 29 in in IN cord-005453-4057qib7 15433 30 pts pts NN cord-005453-4057qib7 15433 31 with with IN cord-005453-4057qib7 15433 32 low low JJ cord-005453-4057qib7 15433 33 HCT HCT NNP cord-005453-4057qib7 15433 34 - - HYPH cord-005453-4057qib7 15433 35 CI CI NNP cord-005453-4057qib7 15433 36 were be VBD cord-005453-4057qib7 15433 37 56 56 CD cord-005453-4057qib7 15433 38 months month NNS cord-005453-4057qib7 15434 1 ( ( -LRB- cord-005453-4057qib7 15434 2 range range NN cord-005453-4057qib7 15434 3 : : : cord-005453-4057qib7 15434 4 0 0 CD cord-005453-4057qib7 15434 5 - - SYM cord-005453-4057qib7 15434 6 156 156 CD cord-005453-4057qib7 15434 7 ) ) -RRB- cord-005453-4057qib7 15434 8 vs vs IN cord-005453-4057qib7 15434 9 6 6 CD cord-005453-4057qib7 15434 10 months month NNS cord-005453-4057qib7 15434 11 in in IN cord-005453-4057qib7 15434 12 intermediate intermediate JJ cord-005453-4057qib7 15434 13 - - HYPH cord-005453-4057qib7 15434 14 high high JJ cord-005453-4057qib7 15434 15 HCT HCT NNP cord-005453-4057qib7 15434 16 - - HYPH cord-005453-4057qib7 15434 17 CI ci NN cord-005453-4057qib7 15434 18 Background background NN cord-005453-4057qib7 15434 19 : : : cord-005453-4057qib7 15435 1 Allo Allo NNP cord-005453-4057qib7 15435 2 - - HYPH cord-005453-4057qib7 15435 3 SCT SCT NNP cord-005453-4057qib7 15435 4 is be VBZ cord-005453-4057qib7 15435 5 a a DT cord-005453-4057qib7 15435 6 potentially potentially RB cord-005453-4057qib7 15435 7 curative curative JJ cord-005453-4057qib7 15435 8 therapy therapy NN cord-005453-4057qib7 15435 9 for for IN cord-005453-4057qib7 15435 10 patients patient NNS cord-005453-4057qib7 15435 11 with with IN cord-005453-4057qib7 15435 12 multiple multiple JJ cord-005453-4057qib7 15435 13 myeloma myeloma NN cord-005453-4057qib7 15435 14 as as IN cord-005453-4057qib7 15435 15 it -PRON- PRP cord-005453-4057qib7 15435 16 provides provide VBZ cord-005453-4057qib7 15435 17 a a DT cord-005453-4057qib7 15435 18 graftversus graftversus NN cord-005453-4057qib7 15435 19 - - HYPH cord-005453-4057qib7 15435 20 myeloma myeloma NN cord-005453-4057qib7 15435 21 effect effect NN cord-005453-4057qib7 15435 22 and and CC cord-005453-4057qib7 15435 23 a a DT cord-005453-4057qib7 15435 24 myeloma myeloma NN cord-005453-4057qib7 15435 25 - - HYPH cord-005453-4057qib7 15435 26 free free JJ cord-005453-4057qib7 15435 27 graft graft NN cord-005453-4057qib7 15435 28 . . . cord-005453-4057qib7 15436 1 Due due IN cord-005453-4057qib7 15436 2 to to IN cord-005453-4057qib7 15436 3 increased increase VBN cord-005453-4057qib7 15436 4 NRM NRM NNP cord-005453-4057qib7 15436 5 and and CC cord-005453-4057qib7 15436 6 unclear unclear JJ cord-005453-4057qib7 15436 7 OS OS NNP cord-005453-4057qib7 15436 8 benefit benefit VBP cord-005453-4057qib7 15436 9 the the DT cord-005453-4057qib7 15436 10 recent recent JJ cord-005453-4057qib7 15436 11 guidelines guideline NNS cord-005453-4057qib7 15436 12 suggested suggest VBD cord-005453-4057qib7 15436 13 allo allo NNP cord-005453-4057qib7 15436 14 - - HYPH cord-005453-4057qib7 15436 15 SCT SCT NNP cord-005453-4057qib7 15436 16 to to TO cord-005453-4057qib7 15436 17 be be VB cord-005453-4057qib7 15436 18 used use VBN cord-005453-4057qib7 15436 19 in in IN cord-005453-4057qib7 15436 20 context context NN cord-005453-4057qib7 15436 21 of of IN cord-005453-4057qib7 15436 22 clinical clinical JJ cord-005453-4057qib7 15436 23 trials trial NNS cord-005453-4057qib7 15436 24 focusing focus VBG cord-005453-4057qib7 15436 25 on on IN cord-005453-4057qib7 15436 26 the the DT cord-005453-4057qib7 15436 27 high high JJ cord-005453-4057qib7 15436 28 - - HYPH cord-005453-4057qib7 15436 29 risk risk NN cord-005453-4057qib7 15436 30 patients patient NNS cord-005453-4057qib7 15436 31 and and CC cord-005453-4057qib7 15436 32 those those DT cord-005453-4057qib7 15436 33 who who WP cord-005453-4057qib7 15436 34 relapsed relapse VBD cord-005453-4057qib7 15436 35 early early RB cord-005453-4057qib7 15436 36 after after IN cord-005453-4057qib7 15436 37 autograft autograft NN cord-005453-4057qib7 15436 38 . . . cord-005453-4057qib7 15437 1 Reduced reduce VBN cord-005453-4057qib7 15437 2 - - HYPH cord-005453-4057qib7 15437 3 intensity intensity NN cord-005453-4057qib7 15437 4 conditioning conditioning NN cord-005453-4057qib7 15437 5 regimens regimen NNS cord-005453-4057qib7 15437 6 may may MD cord-005453-4057qib7 15437 7 improve improve VB cord-005453-4057qib7 15437 8 rate rate NN cord-005453-4057qib7 15437 9 of of IN cord-005453-4057qib7 15437 10 NRM NRM NNP cord-005453-4057qib7 15437 11 ; ; : cord-005453-4057qib7 15437 12 however however RB cord-005453-4057qib7 15437 13 , , , cord-005453-4057qib7 15437 14 optimal optimal JJ cord-005453-4057qib7 15437 15 conditioning conditioning NN cord-005453-4057qib7 15437 16 regimen regimen NN cord-005453-4057qib7 15437 17 is be VBZ cord-005453-4057qib7 15437 18 still still RB cord-005453-4057qib7 15437 19 to to TO cord-005453-4057qib7 15437 20 be be VB cord-005453-4057qib7 15437 21 determined determine VBN cord-005453-4057qib7 15437 22 . . . cord-005453-4057qib7 15438 1 Here here RB cord-005453-4057qib7 15438 2 we -PRON- PRP cord-005453-4057qib7 15438 3 studied study VBD cord-005453-4057qib7 15438 4 conditioning conditioning NN cord-005453-4057qib7 15438 5 regimen regimen NN cord-005453-4057qib7 15438 6 with with IN cord-005453-4057qib7 15438 7 3 3 CD cord-005453-4057qib7 15438 8 alkylating alkylating JJ cord-005453-4057qib7 15438 9 agents agent NNS cord-005453-4057qib7 15438 10 consisting consist VBG cord-005453-4057qib7 15438 11 of of IN cord-005453-4057qib7 15438 12 thiotepa thiotepa NNS cord-005453-4057qib7 15438 13 ( ( -LRB- cord-005453-4057qib7 15438 14 TT TT NNP cord-005453-4057qib7 15438 15 ) ) -RRB- cord-005453-4057qib7 15438 16 , , , cord-005453-4057qib7 15438 17 busulfan busulfan FW cord-005453-4057qib7 15438 18 ( ( -LRB- cord-005453-4057qib7 15438 19 Bu Bu NNP cord-005453-4057qib7 15438 20 ) ) -RRB- cord-005453-4057qib7 15438 21 and and CC cord-005453-4057qib7 15438 22 GvHD GvHD NNP cord-005453-4057qib7 15438 23 prophylaxis prophylaxis NN cord-005453-4057qib7 15438 24 with with IN cord-005453-4057qib7 15438 25 post post JJ cord-005453-4057qib7 15438 26 - - JJ cord-005453-4057qib7 15438 27 transplant transplant NN cord-005453-4057qib7 15438 28 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 15438 29 ( ( -LRB- cord-005453-4057qib7 15438 30 post post NNP cord-005453-4057qib7 15438 31 - - JJ cord-005453-4057qib7 15438 32 Cy Cy NNP cord-005453-4057qib7 15438 33 ) ) -RRB- cord-005453-4057qib7 15438 34 in in IN cord-005453-4057qib7 15438 35 high high JJ cord-005453-4057qib7 15438 36 risk risk NN cord-005453-4057qib7 15438 37 myeloma myeloma NN cord-005453-4057qib7 15438 38 patients patient NNS cord-005453-4057qib7 15438 39 relapsing relapse VBG cord-005453-4057qib7 15438 40 after after IN cord-005453-4057qib7 15438 41 autograft autograft NN cord-005453-4057qib7 15438 42 . . . cord-005453-4057qib7 15439 1 Methods method NNS cord-005453-4057qib7 15439 2 : : : cord-005453-4057qib7 15440 1 A a DT cord-005453-4057qib7 15440 2 total total NN cord-005453-4057qib7 15440 3 of of IN cord-005453-4057qib7 15440 4 40 40 CD cord-005453-4057qib7 15440 5 patients patient NNS cord-005453-4057qib7 15440 6 ( ( -LRB- cord-005453-4057qib7 15440 7 m m NNP cord-005453-4057qib7 15440 8 , , , cord-005453-4057qib7 15440 9 n=23 n=23 IN cord-005453-4057qib7 15440 10 ) ) -RRB- cord-005453-4057qib7 15440 11 with with IN cord-005453-4057qib7 15440 12 median median JJ cord-005453-4057qib7 15440 13 age age NN cord-005453-4057qib7 15440 14 of of IN cord-005453-4057qib7 15440 15 55 55 CD cord-005453-4057qib7 15440 16 years year NNS cord-005453-4057qib7 15440 17 ( ( -LRB- cord-005453-4057qib7 15440 18 range range VBP cord-005453-4057qib7 15440 19 40 40 CD cord-005453-4057qib7 15440 20 - - SYM cord-005453-4057qib7 15440 21 67 67 CD cord-005453-4057qib7 15440 22 ) ) -RRB- cord-005453-4057qib7 15440 23 underwent undergo VBD cord-005453-4057qib7 15440 24 an an DT cord-005453-4057qib7 15440 25 allo allo NN cord-005453-4057qib7 15440 26 - - HYPH cord-005453-4057qib7 15440 27 SCT sct NN cord-005453-4057qib7 15440 28 ( ( -LRB- cord-005453-4057qib7 15440 29 MUD mud NN cord-005453-4057qib7 15440 30 , , , cord-005453-4057qib7 15440 31 n=19 n=19 JJ cord-005453-4057qib7 15440 32 ; ; : cord-005453-4057qib7 15440 33 MRD MRD NNP cord-005453-4057qib7 15440 34 , , , cord-005453-4057qib7 15440 35 n=12 n=12 VBN cord-005453-4057qib7 15440 36 ; ; : cord-005453-4057qib7 15440 37 MMUD MMUD NNP cord-005453-4057qib7 15440 38 , , , cord-005453-4057qib7 15440 39 n=6 n=6 JJ cord-005453-4057qib7 15440 40 , , , cord-005453-4057qib7 15440 41 haploidentical haploidentical JJ cord-005453-4057qib7 15440 42 , , , cord-005453-4057qib7 15440 43 n=3 n=3 NN cord-005453-4057qib7 15440 44 ) ) -RRB- cord-005453-4057qib7 15440 45 during during IN cord-005453-4057qib7 15440 46 a a DT cord-005453-4057qib7 15440 47 period period NN cord-005453-4057qib7 15440 48 from from IN cord-005453-4057qib7 15440 49 2014 2014 CD cord-005453-4057qib7 15440 50 to to IN cord-005453-4057qib7 15440 51 2018 2018 CD cord-005453-4057qib7 15440 52 in in IN cord-005453-4057qib7 15440 53 University University NNP cord-005453-4057qib7 15440 54 of of IN cord-005453-4057qib7 15440 55 Hamburg Hamburg NNP cord-005453-4057qib7 15440 56 . . . cord-005453-4057qib7 15441 1 The the DT cord-005453-4057qib7 15441 2 majority majority NN cord-005453-4057qib7 15441 3 of of IN cord-005453-4057qib7 15441 4 patients patient NNS cord-005453-4057qib7 15441 5 had have VBD cord-005453-4057qib7 15441 6 advanced advanced JJ cord-005453-4057qib7 15441 7 disease disease NN cord-005453-4057qib7 15441 8 ( ( -LRB- cord-005453-4057qib7 15441 9 stage stage NN cord-005453-4057qib7 15441 10 IIIAB IIIAB NNP cord-005453-4057qib7 15441 11 , , , cord-005453-4057qib7 15441 12 73 73 CD cord-005453-4057qib7 15441 13 % % NN cord-005453-4057qib7 15441 14 ) ) -RRB- cord-005453-4057qib7 15441 15 and and CC cord-005453-4057qib7 15441 16 high high JJ cord-005453-4057qib7 15441 17 - - HYPH cord-005453-4057qib7 15441 18 risk risk NN cord-005453-4057qib7 15441 19 cytogenetics cytogenetic NNS cord-005453-4057qib7 15441 20 ( ( -LRB- cord-005453-4057qib7 15441 21 56 56 CD cord-005453-4057qib7 15441 22 % % NN cord-005453-4057qib7 15441 23 ) ) -RRB- cord-005453-4057qib7 15441 24 . . . cord-005453-4057qib7 15442 1 The the DT cord-005453-4057qib7 15442 2 median median JJ cord-005453-4057qib7 15442 3 response response NN cord-005453-4057qib7 15442 4 durartion durartion NN cord-005453-4057qib7 15442 5 after after IN cord-005453-4057qib7 15442 6 autograft autograft NN cord-005453-4057qib7 15442 7 was be VBD cord-005453-4057qib7 15442 8 1.8 1.8 CD cord-005453-4057qib7 15442 9 years year NNS cord-005453-4057qib7 15443 1 ( ( -LRB- cord-005453-4057qib7 15443 2 range range VBP cord-005453-4057qib7 15443 3 0.5 0.5 CD cord-005453-4057qib7 15443 4 - - SYM cord-005453-4057qib7 15443 5 8 8 CD cord-005453-4057qib7 15443 6 . . . cord-005453-4057qib7 15443 7 3 3 CD cord-005453-4057qib7 15443 8 ) ) -RRB- cord-005453-4057qib7 15443 9 . . . cord-005453-4057qib7 15444 1 The the DT cord-005453-4057qib7 15444 2 conditioning conditioning NN cord-005453-4057qib7 15444 3 included include VBD cord-005453-4057qib7 15444 4 TT TT NNP cord-005453-4057qib7 15444 5 ( ( -LRB- cord-005453-4057qib7 15444 6 cum cum NN cord-005453-4057qib7 15444 7 . . . cord-005453-4057qib7 15445 1 dosage dosage NNP cord-005453-4057qib7 15445 2 10mg 10mg NNP cord-005453-4057qib7 15445 3 / / SYM cord-005453-4057qib7 15445 4 kg kg NNP cord-005453-4057qib7 15445 5 ) ) -RRB- cord-005453-4057qib7 15445 6 , , , cord-005453-4057qib7 15445 7 Bu Bu NNP cord-005453-4057qib7 15445 8 ( ( -LRB- cord-005453-4057qib7 15445 9 median median JJ cord-005453-4057qib7 15445 10 cum cum NN cord-005453-4057qib7 15445 11 . . . cord-005453-4057qib7 15446 1 dosage dosage VB cord-005453-4057qib7 15446 2 9.6 9.6 CD cord-005453-4057qib7 15446 3 mg mg NN cord-005453-4057qib7 15447 1 /kg /kg NFP cord-005453-4057qib7 15447 2 i.v i.v NNP cord-005453-4057qib7 15447 3 . . . cord-005453-4057qib7 15448 1 or or CC cord-005453-4057qib7 15448 2 6.4 6.4 CD cord-005453-4057qib7 15448 3 mg mg NNP cord-005453-4057qib7 15448 4 / / SYM cord-005453-4057qib7 15448 5 kg kg NNS cord-005453-4057qib7 15448 6 in in IN cord-005453-4057qib7 15448 7 elderly elderly JJ cord-005453-4057qib7 15448 8 patients patient NNS cord-005453-4057qib7 15448 9 ) ) -RRB- cord-005453-4057qib7 15448 10 and and CC cord-005453-4057qib7 15448 11 post post JJ cord-005453-4057qib7 15448 12 - - JJ cord-005453-4057qib7 15448 13 Cy cy JJ cord-005453-4057qib7 15448 14 ( ( -LRB- cord-005453-4057qib7 15448 15 cum cum NN cord-005453-4057qib7 15448 16 . . . cord-005453-4057qib7 15449 1 dosage dosage NNP cord-005453-4057qib7 15449 2 100mg 100mg NNP cord-005453-4057qib7 15449 3 / / SYM cord-005453-4057qib7 15449 4 kg kg NNP cord-005453-4057qib7 15449 5 , , , cord-005453-4057qib7 15449 6 day day NN cord-005453-4057qib7 15449 7 +3 +3 NN cord-005453-4057qib7 15449 8 and and CC cord-005453-4057qib7 15449 9 +4 +4 LS cord-005453-4057qib7 15449 10 ) ) -RRB- cord-005453-4057qib7 15449 11 . . . cord-005453-4057qib7 15450 1 Eight eight CD cord-005453-4057qib7 15450 2 patients patient NNS cord-005453-4057qib7 15450 3 ( ( -LRB- cord-005453-4057qib7 15450 4 all all DT cord-005453-4057qib7 15450 5 of of IN cord-005453-4057qib7 15450 6 them -PRON- PRP cord-005453-4057qib7 15450 7 received receive VBD cord-005453-4057qib7 15450 8 allografts allograft NNS cord-005453-4057qib7 15450 9 from from IN cord-005453-4057qib7 15450 10 MMUD MMUD NNP cord-005453-4057qib7 15450 11 or or CC cord-005453-4057qib7 15450 12 haploidentical haploidentical JJ cord-005453-4057qib7 15450 13 donors donor NNS cord-005453-4057qib7 15450 14 ) ) -RRB- cord-005453-4057qib7 15450 15 received receive VBD cord-005453-4057qib7 15450 16 additionally additionally RB cord-005453-4057qib7 15450 17 fludarabine fludarabine NN cord-005453-4057qib7 15450 18 ( ( -LRB- cord-005453-4057qib7 15450 19 FLU flu NN cord-005453-4057qib7 15450 20 , , , cord-005453-4057qib7 15450 21 cum cum NN cord-005453-4057qib7 15450 22 . . . cord-005453-4057qib7 15451 1 dosage dosage NN cord-005453-4057qib7 15451 2 of of IN cord-005453-4057qib7 15451 3 Background Background NNP cord-005453-4057qib7 15451 4 : : : cord-005453-4057qib7 15452 1 The the DT cord-005453-4057qib7 15452 2 overall overall JJ cord-005453-4057qib7 15452 3 incidence incidence NN cord-005453-4057qib7 15452 4 of of IN cord-005453-4057qib7 15452 5 active active JJ cord-005453-4057qib7 15452 6 CMV CMV NNP cord-005453-4057qib7 15452 7 infection infection NN cord-005453-4057qib7 15452 8 in in IN cord-005453-4057qib7 15452 9 patients patient NNS cord-005453-4057qib7 15452 10 with with IN cord-005453-4057qib7 15452 11 multiple multiple JJ cord-005453-4057qib7 15452 12 myeloma myeloma NN cord-005453-4057qib7 15452 13 ( ( -LRB- cord-005453-4057qib7 15452 14 MM MM NNP cord-005453-4057qib7 15452 15 ) ) -RRB- cord-005453-4057qib7 15452 16 receiving receive VBG cord-005453-4057qib7 15452 17 Background background NN cord-005453-4057qib7 15452 18 : : : cord-005453-4057qib7 15452 19 Several several JJ cord-005453-4057qib7 15452 20 scoring scoring NN cord-005453-4057qib7 15452 21 systems system NNS cord-005453-4057qib7 15452 22 have have VBP cord-005453-4057qib7 15452 23 been be VBN cord-005453-4057qib7 15452 24 developed develop VBN cord-005453-4057qib7 15452 25 to to TO cord-005453-4057qib7 15452 26 estimate estimate VB cord-005453-4057qib7 15452 27 outcomes outcome NNS cord-005453-4057qib7 15452 28 in in IN cord-005453-4057qib7 15452 29 MDS MDS NNP cord-005453-4057qib7 15452 30 patients patient NNS cord-005453-4057qib7 15452 31 who who WP cord-005453-4057qib7 15452 32 undergo undergo VBP cord-005453-4057qib7 15452 33 AlloHCT AlloHCT NNP cord-005453-4057qib7 15452 34 . . . cord-005453-4057qib7 15453 1 However however RB cord-005453-4057qib7 15453 2 , , , cord-005453-4057qib7 15453 3 none none NN cord-005453-4057qib7 15453 4 of of IN cord-005453-4057qib7 15453 5 them -PRON- PRP cord-005453-4057qib7 15453 6 have have VBP cord-005453-4057qib7 15453 7 been be VBN cord-005453-4057qib7 15453 8 specifically specifically RB cord-005453-4057qib7 15453 9 validated validate VBN cord-005453-4057qib7 15453 10 in in IN cord-005453-4057qib7 15453 11 T T NNP cord-005453-4057qib7 15453 12 cell cell NN cord-005453-4057qib7 15453 13 depleted deplete VBD cord-005453-4057qib7 15453 14 grafts graft NNS cord-005453-4057qib7 15453 15 . . . cord-005453-4057qib7 15454 1 The the DT cord-005453-4057qib7 15454 2 aim aim NN cord-005453-4057qib7 15454 3 of of IN cord-005453-4057qib7 15454 4 this this DT cord-005453-4057qib7 15454 5 study study NN cord-005453-4057qib7 15454 6 is be VBZ cord-005453-4057qib7 15454 7 to to TO cord-005453-4057qib7 15454 8 investigate investigate VB cord-005453-4057qib7 15454 9 the the DT cord-005453-4057qib7 15454 10 prognostic prognostic JJ cord-005453-4057qib7 15454 11 ability ability NN cord-005453-4057qib7 15454 12 of of IN cord-005453-4057qib7 15454 13 a a DT cord-005453-4057qib7 15454 14 recently recently RB cord-005453-4057qib7 15454 15 published publish VBN cord-005453-4057qib7 15454 16 scoring scoring NN cord-005453-4057qib7 15454 17 system system NN cord-005453-4057qib7 15454 18 ( ( -LRB- cord-005453-4057qib7 15454 19 SFGM SFGM NNP cord-005453-4057qib7 15454 20 - - HYPH cord-005453-4057qib7 15454 21 TC TC NNP cord-005453-4057qib7 15454 22 ) ) -RRB- cord-005453-4057qib7 15454 23 in in IN cord-005453-4057qib7 15454 24 a a DT cord-005453-4057qib7 15454 25 cohort cohort NN cord-005453-4057qib7 15454 26 of of IN cord-005453-4057qib7 15454 27 patients patient NNS cord-005453-4057qib7 15454 28 with with IN cord-005453-4057qib7 15454 29 MDS MDS NNP cord-005453-4057qib7 15454 30 who who WP cord-005453-4057qib7 15454 31 underwent undergo VBD cord-005453-4057qib7 15454 32 TCD TCD NNP cord-005453-4057qib7 15454 33 transplants transplant NNS cord-005453-4057qib7 15454 34 . . . cord-005453-4057qib7 15455 1 Methods method NNS cord-005453-4057qib7 15455 2 : : : cord-005453-4057qib7 15455 3 109 109 CD cord-005453-4057qib7 15455 4 patients patient NNS cord-005453-4057qib7 15455 5 underwent undergo VBD cord-005453-4057qib7 15455 6 a a DT cord-005453-4057qib7 15455 7 first first JJ cord-005453-4057qib7 15455 8 TCD TCD NNP cord-005453-4057qib7 15455 9 AlloHCT AlloHCT NNP cord-005453-4057qib7 15455 10 for for IN cord-005453-4057qib7 15455 11 MDS MDS NNP cord-005453-4057qib7 15455 12 from from IN cord-005453-4057qib7 15455 13 2007 2007 CD cord-005453-4057qib7 15455 14 to to IN cord-005453-4057qib7 15455 15 2018 2018 CD cord-005453-4057qib7 15455 16 . . . cord-005453-4057qib7 15456 1 The the DT cord-005453-4057qib7 15456 2 SFGM SFGM NNP cord-005453-4057qib7 15456 3 - - HYPH cord-005453-4057qib7 15456 4 TC TC NNP cord-005453-4057qib7 15456 5 score score NN cord-005453-4057qib7 15456 6 ( ( -LRB- cord-005453-4057qib7 15456 7 Caulier Caulier NNP cord-005453-4057qib7 15456 8 et et NNP cord-005453-4057qib7 15456 9 al al NNP cord-005453-4057qib7 15456 10 . . . cord-005453-4057qib7 15457 1 Curr Curr NNP cord-005453-4057qib7 15457 2 Res Res NNP cord-005453-4057qib7 15457 3 Transl Transl NNP cord-005453-4057qib7 15457 4 Med Med NNP cord-005453-4057qib7 15457 5 . . NNP cord-005453-4057qib7 15457 6 2018 2018 CD cord-005453-4057qib7 15457 7 ) ) -RRB- cord-005453-4057qib7 15457 8 is be VBZ cord-005453-4057qib7 15457 9 performed perform VBN cord-005453-4057qib7 15457 10 at at IN cord-005453-4057qib7 15457 11 day day NN cord-005453-4057qib7 15457 12 100 100 CD cord-005453-4057qib7 15457 13 and and CC cord-005453-4057qib7 15457 14 ranges range VBZ cord-005453-4057qib7 15457 15 from from IN cord-005453-4057qib7 15457 16 0 0 CD cord-005453-4057qib7 15457 17 - - SYM cord-005453-4057qib7 15457 18 8 8 CD cord-005453-4057qib7 15457 19 , , , cord-005453-4057qib7 15457 20 discriminating discriminate VBG cord-005453-4057qib7 15457 21 low low JJ cord-005453-4057qib7 15457 22 ( ( -LRB- cord-005453-4057qib7 15457 23 0 0 NFP cord-005453-4057qib7 15457 24 ) ) -RRB- cord-005453-4057qib7 15457 25 , , , cord-005453-4057qib7 15457 26 intermediate intermediate JJ cord-005453-4057qib7 15457 27 ( ( -LRB- cord-005453-4057qib7 15457 28 1 1 CD cord-005453-4057qib7 15457 29 ) ) -RRB- cord-005453-4057qib7 15457 30 ( ( -LRB- cord-005453-4057qib7 15457 31 2 2 LS cord-005453-4057qib7 15457 32 ) ) -RRB- cord-005453-4057qib7 15457 33 ( ( -LRB- cord-005453-4057qib7 15457 34 3 3 LS cord-005453-4057qib7 15457 35 ) ) -RRB- cord-005453-4057qib7 15457 36 , , , cord-005453-4057qib7 15457 37 and and CC cord-005453-4057qib7 15457 38 high high JJ cord-005453-4057qib7 15457 39 risk risk NN cord-005453-4057qib7 15457 40 ( ( -LRB- cord-005453-4057qib7 15457 41 4 4 CD cord-005453-4057qib7 15457 42 - - SYM cord-005453-4057qib7 15457 43 8 8 CD cord-005453-4057qib7 15457 44 ) ) -RRB- cord-005453-4057qib7 15457 45 . . . cord-005453-4057qib7 15458 1 Additional additional JJ cord-005453-4057qib7 15458 2 analyses analysis NNS cord-005453-4057qib7 15458 3 were be VBD cord-005453-4057qib7 15458 4 performed perform VBN cord-005453-4057qib7 15458 5 at at IN cord-005453-4057qib7 15458 6 day day NN cord-005453-4057qib7 15458 7 180 180 CD cord-005453-4057qib7 15458 8 and and CC cord-005453-4057qib7 15458 9 day day NN cord-005453-4057qib7 15458 10 365 365 CD cord-005453-4057qib7 15458 11 . . . cord-005453-4057qib7 15459 1 A a DT cord-005453-4057qib7 15459 2 landmark landmark NN cord-005453-4057qib7 15459 3 analysis analysis NN cord-005453-4057qib7 15459 4 was be VBD cord-005453-4057qib7 15459 5 done do VBN cord-005453-4057qib7 15459 6 at at IN cord-005453-4057qib7 15459 7 each each DT cord-005453-4057qib7 15459 8 time time NN cord-005453-4057qib7 15459 9 point point NN cord-005453-4057qib7 15459 10 for for IN cord-005453-4057qib7 15459 11 the the DT cord-005453-4057qib7 15459 12 day day NN cord-005453-4057qib7 15459 13 100 100 CD cord-005453-4057qib7 15459 14 , , , cord-005453-4057qib7 15459 15 180 180 CD cord-005453-4057qib7 15459 16 , , , cord-005453-4057qib7 15459 17 and and CC cord-005453-4057qib7 15459 18 365 365 CD cord-005453-4057qib7 15459 19 analyses analysis NNS cord-005453-4057qib7 15459 20 , , , cord-005453-4057qib7 15459 21 respectively respectively RB cord-005453-4057qib7 15459 22 . . . cord-005453-4057qib7 15460 1 Background background NN cord-005453-4057qib7 15460 2 : : : cord-005453-4057qib7 15461 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 15461 2 stem stem NN cord-005453-4057qib7 15461 3 cell cell NN cord-005453-4057qib7 15461 4 transplantation transplantation NN cord-005453-4057qib7 15461 5 ( ( -LRB- cord-005453-4057qib7 15461 6 HSCT HSCT NNP cord-005453-4057qib7 15461 7 ) ) -RRB- cord-005453-4057qib7 15461 8 is be VBZ cord-005453-4057qib7 15461 9 the the DT cord-005453-4057qib7 15461 10 only only JJ cord-005453-4057qib7 15461 11 curative curative JJ cord-005453-4057qib7 15461 12 procedure procedure NN cord-005453-4057qib7 15461 13 for for IN cord-005453-4057qib7 15461 14 the the DT cord-005453-4057qib7 15461 15 treatment treatment NN cord-005453-4057qib7 15461 16 of of IN cord-005453-4057qib7 15461 17 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 15461 18 syndrome syndrome NN cord-005453-4057qib7 15461 19 ( ( -LRB- cord-005453-4057qib7 15461 20 MDS MDS NNP cord-005453-4057qib7 15461 21 ) ) -RRB- cord-005453-4057qib7 15461 22 , , , cord-005453-4057qib7 15461 23 but but CC cord-005453-4057qib7 15461 24 among among IN cord-005453-4057qib7 15461 25 several several JJ cord-005453-4057qib7 15461 26 limiting limit VBG cord-005453-4057qib7 15461 27 factors factor NNS cord-005453-4057qib7 15461 28 for for IN cord-005453-4057qib7 15461 29 its -PRON- PRP$ cord-005453-4057qib7 15461 30 accomplishment accomplishment NN cord-005453-4057qib7 15461 31 , , , cord-005453-4057qib7 15461 32 such such JJ cord-005453-4057qib7 15461 33 as as IN cord-005453-4057qib7 15461 34 the the DT cord-005453-4057qib7 15461 35 patient´s patient´s NNP cord-005453-4057qib7 15461 36 performance performance NN cord-005453-4057qib7 15461 37 status status NN cord-005453-4057qib7 15461 38 , , , cord-005453-4057qib7 15461 39 is be VBZ cord-005453-4057qib7 15461 40 a a DT cord-005453-4057qib7 15461 41 very very RB cord-005453-4057qib7 15461 42 relevant relevant JJ cord-005453-4057qib7 15461 43 issue issue NN cord-005453-4057qib7 15461 44 , , , cord-005453-4057qib7 15461 45 i.e. i.e. FW cord-005453-4057qib7 15461 46 , , , cord-005453-4057qib7 15461 47 the the DT cord-005453-4057qib7 15461 48 availability availability NN cord-005453-4057qib7 15461 49 of of IN cord-005453-4057qib7 15461 50 a a DT cord-005453-4057qib7 15461 51 compatible compatible JJ cord-005453-4057qib7 15461 52 HLA HLA NNP cord-005453-4057qib7 15461 53 donor donor NN cord-005453-4057qib7 15461 54 and and CC cord-005453-4057qib7 15461 55 , , , cord-005453-4057qib7 15461 56 when when WRB cord-005453-4057qib7 15461 57 available available JJ cord-005453-4057qib7 15461 58 , , , cord-005453-4057qib7 15461 59 very very RB cord-005453-4057qib7 15461 60 often often RB cord-005453-4057qib7 15461 61 the the DT cord-005453-4057qib7 15461 62 donor´s donor´s NNP cord-005453-4057qib7 15461 63 age age NN cord-005453-4057qib7 15461 64 and and CC cord-005453-4057qib7 15461 65 comorbidities comorbiditie NNS cord-005453-4057qib7 15461 66 also also RB cord-005453-4057qib7 15461 67 constitute constitute VBP cord-005453-4057qib7 15461 68 factors factor NNS cord-005453-4057qib7 15461 69 that that WDT cord-005453-4057qib7 15461 70 hinder hinder VBP cord-005453-4057qib7 15461 71 this this DT cord-005453-4057qib7 15461 72 medical medical JJ cord-005453-4057qib7 15461 73 conduct conduct NN cord-005453-4057qib7 15461 74 . . . cord-005453-4057qib7 15462 1 Considering consider VBG cord-005453-4057qib7 15462 2 this this DT cord-005453-4057qib7 15462 3 scenario scenario NN cord-005453-4057qib7 15462 4 , , , cord-005453-4057qib7 15462 5 the the DT cord-005453-4057qib7 15462 6 possibility possibility NN cord-005453-4057qib7 15462 7 of of IN cord-005453-4057qib7 15462 8 a a DT cord-005453-4057qib7 15462 9 haploidentical haploidentical JJ cord-005453-4057qib7 15462 10 transplantation transplantation NN cord-005453-4057qib7 15462 11 ( ( -LRB- cord-005453-4057qib7 15462 12 HT HT NNP cord-005453-4057qib7 15462 13 ) ) -RRB- cord-005453-4057qib7 15462 14 has have VBZ cord-005453-4057qib7 15462 15 emerged emerge VBN cord-005453-4057qib7 15462 16 as as IN cord-005453-4057qib7 15462 17 an an DT cord-005453-4057qib7 15462 18 option option NN cord-005453-4057qib7 15462 19 . . . cord-005453-4057qib7 15463 1 In in IN cord-005453-4057qib7 15463 2 Latin Latin NNP cord-005453-4057qib7 15463 3 America America NNP cord-005453-4057qib7 15463 4 , , , cord-005453-4057qib7 15463 5 HT HT NNP cord-005453-4057qib7 15463 6 has have VBZ cord-005453-4057qib7 15463 7 been be VBN cord-005453-4057qib7 15463 8 included include VBN cord-005453-4057qib7 15463 9 as as IN cord-005453-4057qib7 15463 10 a a DT cord-005453-4057qib7 15463 11 treatment treatment NN cord-005453-4057qib7 15463 12 option option NN cord-005453-4057qib7 15463 13 since since IN cord-005453-4057qib7 15463 14 2014 2014 CD cord-005453-4057qib7 15463 15 . . . cord-005453-4057qib7 15464 1 Since since IN cord-005453-4057qib7 15464 2 then then RB cord-005453-4057qib7 15464 3 , , , cord-005453-4057qib7 15464 4 these these DT cord-005453-4057qib7 15464 5 patients patient NNS cord-005453-4057qib7 15464 6 have have VBP cord-005453-4057qib7 15464 7 been be VBN cord-005453-4057qib7 15464 8 included include VBN cord-005453-4057qib7 15464 9 in in IN cord-005453-4057qib7 15464 10 the the DT cord-005453-4057qib7 15464 11 Latin Latin NNP cord-005453-4057qib7 15464 12 American American NNP cord-005453-4057qib7 15464 13 Registry Registry NNP cord-005453-4057qib7 15464 14 of of IN cord-005453-4057qib7 15464 15 Transplantation Transplantation NNP cord-005453-4057qib7 15464 16 in in IN cord-005453-4057qib7 15464 17 Myelodysplastic Myelodysplastic NNP cord-005453-4057qib7 15464 18 Syndrome Syndrome NNP cord-005453-4057qib7 15464 19 , , , cord-005453-4057qib7 15464 20 making make VBG cord-005453-4057qib7 15464 21 it -PRON- PRP cord-005453-4057qib7 15464 22 possible possible JJ cord-005453-4057qib7 15464 23 to to TO cord-005453-4057qib7 15464 24 analyze analyze VB cord-005453-4057qib7 15464 25 the the DT cord-005453-4057qib7 15464 26 viability viability NN cord-005453-4057qib7 15464 27 and and CC cord-005453-4057qib7 15464 28 results result NNS cord-005453-4057qib7 15464 29 of of IN cord-005453-4057qib7 15464 30 these these DT cord-005453-4057qib7 15464 31 transplants transplant NNS cord-005453-4057qib7 15464 32 . . . cord-005453-4057qib7 15465 1 Methods method NNS cord-005453-4057qib7 15465 2 : : : cord-005453-4057qib7 15466 1 From from IN cord-005453-4057qib7 15466 2 October October NNP cord-005453-4057qib7 15466 3 2012 2012 CD cord-005453-4057qib7 15466 4 to to IN cord-005453-4057qib7 15466 5 October October NNP cord-005453-4057qib7 15466 6 2018 2018 CD cord-005453-4057qib7 15466 7 , , , cord-005453-4057qib7 15466 8 seventeen seventeen CD cord-005453-4057qib7 15466 9 ( ( -LRB- cord-005453-4057qib7 15466 10 17 17 CD cord-005453-4057qib7 15466 11 ) ) -RRB- cord-005453-4057qib7 15466 12 patients patient NNS cord-005453-4057qib7 15466 13 were be VBD cord-005453-4057qib7 15466 14 transplanted transplant VBN cord-005453-4057qib7 15466 15 with with IN cord-005453-4057qib7 15466 16 a a DT cord-005453-4057qib7 15466 17 haploidentical haploidentical JJ cord-005453-4057qib7 15466 18 donor donor NN cord-005453-4057qib7 15466 19 and and CC cord-005453-4057qib7 15466 20 included include VBN cord-005453-4057qib7 15466 21 in in IN cord-005453-4057qib7 15466 22 the the DT cord-005453-4057qib7 15466 23 Latin Latin NNP cord-005453-4057qib7 15466 24 American American NNP cord-005453-4057qib7 15466 25 Registry Registry NNP cord-005453-4057qib7 15466 26 . . . cord-005453-4057qib7 15467 1 None none NN cord-005453-4057qib7 15467 2 of of IN cord-005453-4057qib7 15467 3 these these DT cord-005453-4057qib7 15467 4 patients patient NNS cord-005453-4057qib7 15467 5 had have VBD cord-005453-4057qib7 15467 6 an an DT cord-005453-4057qib7 15467 7 identical identical JJ cord-005453-4057qib7 15467 8 HLA HLA NNP cord-005453-4057qib7 15467 9 ( ( -LRB- cord-005453-4057qib7 15467 10 8/8 8/8 CD cord-005453-4057qib7 15467 11 match match NN cord-005453-4057qib7 15467 12 ) ) -RRB- cord-005453-4057qib7 15467 13 related related JJ cord-005453-4057qib7 15467 14 or or CC cord-005453-4057qib7 15467 15 unrelated unrelated JJ cord-005453-4057qib7 15467 16 donor donor NN cord-005453-4057qib7 15467 17 . . . cord-005453-4057qib7 15468 1 Data datum NNS cord-005453-4057qib7 15468 2 were be VBD cord-005453-4057qib7 15468 3 obtained obtain VBN cord-005453-4057qib7 15468 4 from from IN cord-005453-4057qib7 15468 5 the the DT cord-005453-4057qib7 15468 6 Latin Latin NNP cord-005453-4057qib7 15468 7 American American NNP cord-005453-4057qib7 15468 8 Registry Registry NNP cord-005453-4057qib7 15468 9 of of IN cord-005453-4057qib7 15468 10 HSCT HSCT NNP cord-005453-4057qib7 15468 11 in in IN cord-005453-4057qib7 15468 12 MDS MDS NNP cord-005453-4057qib7 15468 13 . . . cord-005453-4057qib7 15469 1 The the DT cord-005453-4057qib7 15469 2 statistical statistical JJ cord-005453-4057qib7 15469 3 analyses analysis NNS cord-005453-4057qib7 15469 4 were be VBD cord-005453-4057qib7 15469 5 performed perform VBN cord-005453-4057qib7 15469 6 using use VBG cord-005453-4057qib7 15469 7 the the DT cord-005453-4057qib7 15469 8 software software NN cord-005453-4057qib7 15469 9 SPSS SPSS NNP cord-005453-4057qib7 15469 10 , , , cord-005453-4057qib7 15469 11 version version NN cord-005453-4057qib7 15469 12 23.1 23.1 CD cord-005453-4057qib7 15469 13 and and CC cord-005453-4057qib7 15469 14 Graphpad Graphpad NNP cord-005453-4057qib7 15469 15 Prism Prism NNP cord-005453-4057qib7 15469 16 version version NN cord-005453-4057qib7 15469 17 5.0 5.0 CD cord-005453-4057qib7 15469 18 , , , cord-005453-4057qib7 15469 19 with with IN cord-005453-4057qib7 15469 20 significance significance NN cord-005453-4057qib7 15469 21 being be VBG cord-005453-4057qib7 15469 22 set set VBN cord-005453-4057qib7 15469 23 at at IN cord-005453-4057qib7 15469 24 p p NN cord-005453-4057qib7 15469 25 < < XX cord-005453-4057qib7 15469 26 0.05.Results 0.05.Results NNP cord-005453-4057qib7 15469 27 : : : cord-005453-4057qib7 15470 1 Table table NN cord-005453-4057qib7 15470 2 1 1 CD cord-005453-4057qib7 15470 3 shows show VBZ cord-005453-4057qib7 15470 4 the the DT cord-005453-4057qib7 15470 5 patients patient NNS cord-005453-4057qib7 15470 6 and and CC cord-005453-4057qib7 15470 7 their -PRON- PRP$ cord-005453-4057qib7 15470 8 characteristics characteristic NNS cord-005453-4057qib7 15470 9 . . . cord-005453-4057qib7 15471 1 All all DT cord-005453-4057qib7 15471 2 donors donor NNS cord-005453-4057qib7 15471 3 were be VBD cord-005453-4057qib7 15471 4 haploidentical haploidentical JJ cord-005453-4057qib7 15471 5 . . . cord-005453-4057qib7 15472 1 There there EX cord-005453-4057qib7 15472 2 was be VBD cord-005453-4057qib7 15472 3 a a DT cord-005453-4057qib7 15472 4 predominance predominance NN cord-005453-4057qib7 15472 5 of of IN cord-005453-4057qib7 15472 6 reduced reduce VBN cord-005453-4057qib7 15472 7 intensity intensity NN cord-005453-4057qib7 15472 8 conditioning conditioning NN cord-005453-4057qib7 15472 9 , , , cord-005453-4057qib7 15472 10 which which WDT cord-005453-4057qib7 15472 11 was be VBD cord-005453-4057qib7 15472 12 performed perform VBN cord-005453-4057qib7 15472 13 in in IN cord-005453-4057qib7 15472 14 13 13 CD cord-005453-4057qib7 15472 15 patients patient NNS cord-005453-4057qib7 15472 16 ( ( -LRB- cord-005453-4057qib7 15472 17 76.5 76.5 CD cord-005453-4057qib7 15472 18 % % NN cord-005453-4057qib7 15472 19 ) ) -RRB- cord-005453-4057qib7 15472 20 , , , cord-005453-4057qib7 15472 21 whereas whereas IN cord-005453-4057qib7 15472 22 the the DT cord-005453-4057qib7 15472 23 others other NNS cord-005453-4057qib7 15472 24 received receive VBD cord-005453-4057qib7 15472 25 the the DT cord-005453-4057qib7 15472 26 myeloablative myeloablative JJ cord-005453-4057qib7 15472 27 conditioning conditioning NN cord-005453-4057qib7 15472 28 . . . cord-005453-4057qib7 15473 1 Cell cell NN cord-005453-4057qib7 15473 2 source source NN cord-005453-4057qib7 15473 3 was be VBD cord-005453-4057qib7 15473 4 peripheral peripheral JJ cord-005453-4057qib7 15473 5 blood blood NN cord-005453-4057qib7 15473 6 in in IN cord-005453-4057qib7 15473 7 10 10 CD cord-005453-4057qib7 15473 8 ( ( -LRB- cord-005453-4057qib7 15473 9 58.8 58.8 CD cord-005453-4057qib7 15473 10 % % NN cord-005453-4057qib7 15473 11 ) ) -RRB- cord-005453-4057qib7 15473 12 and and CC cord-005453-4057qib7 15473 13 bone bone NN cord-005453-4057qib7 15473 14 marrow marrow NN cord-005453-4057qib7 15473 15 in in IN cord-005453-4057qib7 15473 16 7 7 CD cord-005453-4057qib7 15473 17 ( ( -LRB- cord-005453-4057qib7 15473 18 41.2 41.2 CD cord-005453-4057qib7 15473 19 % % NN cord-005453-4057qib7 15473 20 ) ) -RRB- cord-005453-4057qib7 15473 21 of of IN cord-005453-4057qib7 15473 22 the the DT cord-005453-4057qib7 15473 23 patients patient NNS cord-005453-4057qib7 15473 24 . . . cord-005453-4057qib7 15474 1 Graft graft NN cord-005453-4057qib7 15474 2 - - HYPH cord-005453-4057qib7 15474 3 versus versus IN cord-005453-4057qib7 15474 4 - - HYPH cord-005453-4057qib7 15474 5 host host NN cord-005453-4057qib7 15474 6 disease disease NN cord-005453-4057qib7 15474 7 ( ( -LRB- cord-005453-4057qib7 15474 8 GVHD GVHD NNP cord-005453-4057qib7 15474 9 ) ) -RRB- cord-005453-4057qib7 15474 10 prophylaxis prophylaxis NN cord-005453-4057qib7 15474 11 in in IN cord-005453-4057qib7 15474 12 post post JJ cord-005453-4057qib7 15474 13 - - JJ cord-005453-4057qib7 15474 14 HSCT HSCT NNP cord-005453-4057qib7 15474 15 was be VBD cord-005453-4057qib7 15474 16 carried carry VBN cord-005453-4057qib7 15474 17 out out RP cord-005453-4057qib7 15474 18 with with IN cord-005453-4057qib7 15474 19 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 15474 20 50 50 CD cord-005453-4057qib7 15474 21 mg mg NNP cord-005453-4057qib7 15474 22 / / SYM cord-005453-4057qib7 15474 23 kg kg NNS cord-005453-4057qib7 15474 24 on on IN cord-005453-4057qib7 15474 25 D+3 d+3 NN cord-005453-4057qib7 15474 26 and and CC cord-005453-4057qib7 15474 27 D+5 d+5 NN cord-005453-4057qib7 15474 28 , , , cord-005453-4057qib7 15474 29 cyclosporin cyclosporin NN cord-005453-4057qib7 15474 30 from from IN cord-005453-4057qib7 15474 31 D0 d0 NN cord-005453-4057qib7 15474 32 and and CC cord-005453-4057qib7 15474 33 mycophenolate mycophenolate NN cord-005453-4057qib7 15474 34 from from IN cord-005453-4057qib7 15474 35 D+1 D+1 NNP cord-005453-4057qib7 15474 36 . . . cord-005453-4057qib7 15475 1 Complete complete JJ cord-005453-4057qib7 15475 2 hematologic hematologic JJ cord-005453-4057qib7 15475 3 recovery recovery NN cord-005453-4057qib7 15475 4 was be VBD cord-005453-4057qib7 15475 5 achieved achieve VBN cord-005453-4057qib7 15475 6 in in IN cord-005453-4057qib7 15475 7 16 16 CD cord-005453-4057qib7 15475 8 ( ( -LRB- cord-005453-4057qib7 15475 9 94.1 94.1 CD cord-005453-4057qib7 15475 10 % % NN cord-005453-4057qib7 15475 11 ) ) -RRB- cord-005453-4057qib7 15475 12 patients patient NNS cord-005453-4057qib7 15475 13 . . . cord-005453-4057qib7 15476 1 The the DT cord-005453-4057qib7 15476 2 incidence incidence NN cord-005453-4057qib7 15476 3 of of IN cord-005453-4057qib7 15476 4 grade grade NN cord-005453-4057qib7 15476 5 II II NNP cord-005453-4057qib7 15476 6 - - HYPH cord-005453-4057qib7 15476 7 IV IV NNP cord-005453-4057qib7 15476 8 acute acute JJ cord-005453-4057qib7 15476 9 GVHD GVHD NNP cord-005453-4057qib7 15476 10 was be VBD cord-005453-4057qib7 15476 11 11.7 11.7 CD cord-005453-4057qib7 15476 12 % % NN cord-005453-4057qib7 15476 13 , , , cord-005453-4057qib7 15476 14 whereas whereas IN cord-005453-4057qib7 15476 15 chronic chronic JJ cord-005453-4057qib7 15476 16 GVHD GVHD NNP cord-005453-4057qib7 15476 17 was be VBD cord-005453-4057qib7 15476 18 5.8 5.8 CD cord-005453-4057qib7 15476 19 % % NN cord-005453-4057qib7 15476 20 . . . cord-005453-4057qib7 15477 1 One one CD cord-005453-4057qib7 15477 2 death death NN cord-005453-4057qib7 15477 3 occurred occur VBD cord-005453-4057qib7 15477 4 due due JJ cord-005453-4057qib7 15477 5 to to IN cord-005453-4057qib7 15477 6 graft graft NN cord-005453-4057qib7 15477 7 failure failure NN cord-005453-4057qib7 15477 8 and and CC cord-005453-4057qib7 15477 9 none none NN cord-005453-4057qib7 15477 10 of of IN cord-005453-4057qib7 15477 11 the the DT cord-005453-4057qib7 15477 12 patients patient NNS cord-005453-4057qib7 15477 13 showed show VBD cord-005453-4057qib7 15477 14 autologous autologous JJ cord-005453-4057qib7 15477 15 recovery recovery NN cord-005453-4057qib7 15477 16 . . . cord-005453-4057qib7 15478 1 Three three CD cord-005453-4057qib7 15478 2 other other JJ cord-005453-4057qib7 15478 3 patients patient NNS cord-005453-4057qib7 15478 4 died die VBD cord-005453-4057qib7 15478 5 . . . cord-005453-4057qib7 15479 1 One one CD cord-005453-4057qib7 15479 2 on on IN cord-005453-4057qib7 15479 3 D+210 d+210 NN cord-005453-4057qib7 15479 4 due due IN cord-005453-4057qib7 15479 5 to to IN cord-005453-4057qib7 15479 6 a a DT cord-005453-4057qib7 15479 7 fungal fungal JJ cord-005453-4057qib7 15479 8 infection infection NN cord-005453-4057qib7 15479 9 , , , cord-005453-4057qib7 15479 10 the the DT cord-005453-4057qib7 15479 11 second second JJ cord-005453-4057qib7 15479 12 on on IN cord-005453-4057qib7 15479 13 D+90 d+90 IN cord-005453-4057qib7 15479 14 due due IN cord-005453-4057qib7 15479 15 to to IN cord-005453-4057qib7 15479 16 sinusoidal sinusoidal JJ cord-005453-4057qib7 15479 17 obstruction obstruction NN cord-005453-4057qib7 15479 18 syndrome syndrome NN cord-005453-4057qib7 15479 19 and and CC cord-005453-4057qib7 15479 20 a a DT cord-005453-4057qib7 15479 21 third third NN cord-005453-4057qib7 15479 22 on on IN cord-005453-4057qib7 15479 23 D+61 d+61 NN cord-005453-4057qib7 15479 24 due due IN cord-005453-4057qib7 15479 25 to to IN cord-005453-4057qib7 15479 26 pneumonia pneumonia NN cord-005453-4057qib7 15479 27 caused cause VBN cord-005453-4057qib7 15479 28 by by IN cord-005453-4057qib7 15479 29 Pseudomonas Pseudomonas NNP cord-005453-4057qib7 15479 30 . . . cord-005453-4057qib7 15480 1 Regarding regard VBG cord-005453-4057qib7 15480 2 overall overall JJ cord-005453-4057qib7 15480 3 complications complication NNS cord-005453-4057qib7 15480 4 , , , cord-005453-4057qib7 15480 5 there there EX cord-005453-4057qib7 15480 6 was be VBD cord-005453-4057qib7 15480 7 a a DT cord-005453-4057qib7 15480 8 predominance predominance NN cord-005453-4057qib7 15480 9 of of IN cord-005453-4057qib7 15480 10 mucositis mucositis NNP cord-005453-4057qib7 15480 11 ( ( -LRB- cord-005453-4057qib7 15480 12 47 47 CD cord-005453-4057qib7 15480 13 % % NN cord-005453-4057qib7 15480 14 ) ) -RRB- cord-005453-4057qib7 15480 15 , , , cord-005453-4057qib7 15480 16 overall overall JJ cord-005453-4057qib7 15480 17 infections infection NNS cord-005453-4057qib7 15480 18 ( ( -LRB- cord-005453-4057qib7 15480 19 35.2 35.2 CD cord-005453-4057qib7 15480 20 % % NN cord-005453-4057qib7 15480 21 ) ) -RRB- cord-005453-4057qib7 15480 22 and and CC cord-005453-4057qib7 15480 23 reactivated reactivate VBD cord-005453-4057qib7 15480 24 CMV CMV NNP cord-005453-4057qib7 15480 25 in in IN cord-005453-4057qib7 15480 26 23.5 23.5 CD cord-005453-4057qib7 15480 27 % % NN cord-005453-4057qib7 15480 28 of of IN cord-005453-4057qib7 15480 29 cases case NNS cord-005453-4057qib7 15480 30 . . . cord-005453-4057qib7 15481 1 Of of IN cord-005453-4057qib7 15481 2 the the DT cord-005453-4057qib7 15481 3 total total JJ cord-005453-4057qib7 15481 4 number number NN cord-005453-4057qib7 15481 5 of of IN cord-005453-4057qib7 15481 6 living live VBG cord-005453-4057qib7 15481 7 patients patient NNS cord-005453-4057qib7 15481 8 , , , cord-005453-4057qib7 15481 9 8 8 CD cord-005453-4057qib7 15481 10 ( ( -LRB- cord-005453-4057qib7 15481 11 47 47 CD cord-005453-4057qib7 15481 12 % % NN cord-005453-4057qib7 15481 13 ) ) -RRB- cord-005453-4057qib7 15481 14 achieved achieve VBN cord-005453-4057qib7 15481 15 complete complete JJ cord-005453-4057qib7 15481 16 remission remission NN cord-005453-4057qib7 15481 17 and and CC cord-005453-4057qib7 15481 18 5 5 CD cord-005453-4057qib7 15481 19 ( ( -LRB- cord-005453-4057qib7 15481 20 29.4 29.4 CD cord-005453-4057qib7 15481 21 % % NN cord-005453-4057qib7 15481 22 ) ) -RRB- cord-005453-4057qib7 15481 23 showed show VBD cord-005453-4057qib7 15481 24 disease disease NN cord-005453-4057qib7 15481 25 relapse relapse NN cord-005453-4057qib7 15481 26 . . . cord-005453-4057qib7 15482 1 The the DT cord-005453-4057qib7 15482 2 mean mean JJ cord-005453-4057qib7 15482 3 follow follow NN cord-005453-4057qib7 15482 4 - - HYPH cord-005453-4057qib7 15482 5 up up NN cord-005453-4057qib7 15482 6 was be VBD cord-005453-4057qib7 15482 7 39 39 CD cord-005453-4057qib7 15482 8 months month NNS cord-005453-4057qib7 15482 9 ( ( -LRB- cord-005453-4057qib7 15482 10 ranging range VBG cord-005453-4057qib7 15482 11 from from IN cord-005453-4057qib7 15482 12 5 5 CD cord-005453-4057qib7 15482 13 to to TO cord-005453-4057qib7 15482 14 72 72 CD cord-005453-4057qib7 15482 15 months month NNS cord-005453-4057qib7 15482 16 ) ) -RRB- cord-005453-4057qib7 15482 17 . . . cord-005453-4057qib7 15483 1 The the DT cord-005453-4057qib7 15483 2 lowest low JJS cord-005453-4057qib7 15483 3 probability probability NN cord-005453-4057qib7 15483 4 of of IN cord-005453-4057qib7 15483 5 disease disease NN cord-005453-4057qib7 15483 6 - - HYPH cord-005453-4057qib7 15483 7 free free JJ cord-005453-4057qib7 15483 8 survival survival NN cord-005453-4057qib7 15483 9 at at IN cord-005453-4057qib7 15483 10 3 3 CD cord-005453-4057qib7 15483 11 years year NNS cord-005453-4057qib7 15483 12 was be VBD cord-005453-4057qib7 15483 13 79 79 CD cord-005453-4057qib7 15483 14 % % NN cord-005453-4057qib7 15483 15 ( ( -LRB- cord-005453-4057qib7 15483 16 95 95 CD cord-005453-4057qib7 15483 17 % % NN cord-005453-4057qib7 15483 18 CI ci NN cord-005453-4057qib7 15483 19 : : : cord-005453-4057qib7 15483 20 71.48 71.48 CD cord-005453-4057qib7 15483 21 -88.51).Background -88.51).background CD cord-005453-4057qib7 15483 22 : : : cord-005453-4057qib7 15483 23 Relapse relapse NN cord-005453-4057qib7 15483 24 is be VBZ cord-005453-4057qib7 15483 25 the the DT cord-005453-4057qib7 15483 26 most most RBS cord-005453-4057qib7 15483 27 important important JJ cord-005453-4057qib7 15483 28 cause cause NN cord-005453-4057qib7 15483 29 of of IN cord-005453-4057qib7 15483 30 failure failure NN cord-005453-4057qib7 15483 31 after after IN cord-005453-4057qib7 15483 32 allogeneic allogeneic JJ cord-005453-4057qib7 15483 33 hematopoietic hematopoietic JJ cord-005453-4057qib7 15483 34 stem stem NN cord-005453-4057qib7 15483 35 cell cell NN cord-005453-4057qib7 15483 36 transplantation transplantation NN cord-005453-4057qib7 15483 37 ( ( -LRB- cord-005453-4057qib7 15483 38 HSCT HSCT NNP cord-005453-4057qib7 15483 39 ) ) -RRB- cord-005453-4057qib7 15483 40 for for IN cord-005453-4057qib7 15483 41 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 15483 42 - - HYPH cord-005453-4057qib7 15483 43 positive positive JJ cord-005453-4057qib7 15483 44 acute acute JJ cord-005453-4057qib7 15483 45 myeloid myeloid NN cord-005453-4057qib7 15483 46 leukemia leukemia NN cord-005453-4057qib7 15483 47 ( ( -LRB- cord-005453-4057qib7 15483 48 AML AML NNP cord-005453-4057qib7 15483 49 ) ) -RRB- cord-005453-4057qib7 15483 50 . . . cord-005453-4057qib7 15484 1 Treatment treatment NN cord-005453-4057qib7 15484 2 with with IN cord-005453-4057qib7 15484 3 FLT3 FLT3 NNP cord-005453-4057qib7 15484 4 tyrosine tyrosine NN cord-005453-4057qib7 15484 5 kinase kinase NN cord-005453-4057qib7 15484 6 inhibitors inhibitor NNS cord-005453-4057qib7 15484 7 ( ( -LRB- cord-005453-4057qib7 15484 8 TKI TKI NNP cord-005453-4057qib7 15484 9 ) ) -RRB- cord-005453-4057qib7 15484 10 constitutes constitute VBZ cord-005453-4057qib7 15484 11 a a DT cord-005453-4057qib7 15484 12 promising promising JJ cord-005453-4057qib7 15484 13 clinical clinical JJ cord-005453-4057qib7 15484 14 approach approach NN cord-005453-4057qib7 15484 15 to to TO cord-005453-4057qib7 15484 16 induce induce VB cord-005453-4057qib7 15484 17 remission remission NN cord-005453-4057qib7 15484 18 without without IN cord-005453-4057qib7 15484 19 conventional conventional JJ cord-005453-4057qib7 15484 20 chemotherapy chemotherapy NN cord-005453-4057qib7 15484 21 . . . cord-005453-4057qib7 15485 1 Methods method NNS cord-005453-4057qib7 15485 2 : : : cord-005453-4057qib7 15486 1 A a DT cord-005453-4057qib7 15486 2 50 50 CD cord-005453-4057qib7 15486 3 year year NN cord-005453-4057qib7 15486 4 - - HYPH cord-005453-4057qib7 15486 5 old old JJ cord-005453-4057qib7 15486 6 woman woman NN cord-005453-4057qib7 15486 7 diagnosed diagnose VBN cord-005453-4057qib7 15486 8 with with IN cord-005453-4057qib7 15486 9 AML AML NNP cord-005453-4057qib7 15486 10 secondary secondary JJ cord-005453-4057qib7 15486 11 to to IN cord-005453-4057qib7 15486 12 myelodisplastic myelodisplastic NNP cord-005453-4057qib7 15486 13 syndrome syndrome NN cord-005453-4057qib7 15486 14 ( ( -LRB- cord-005453-4057qib7 15486 15 MDS MDS NNP cord-005453-4057qib7 15486 16 ) ) -RRB- cord-005453-4057qib7 15486 17 with with IN cord-005453-4057qib7 15486 18 NPM1 NPM1 NNP cord-005453-4057qib7 15486 19 mutation mutation NN cord-005453-4057qib7 15486 20 and and CC cord-005453-4057qib7 15486 21 internal internal JJ cord-005453-4057qib7 15486 22 tandem tandem JJ cord-005453-4057qib7 15486 23 duplications duplication NNS cord-005453-4057qib7 15486 24 of of IN cord-005453-4057qib7 15486 25 the the DT cord-005453-4057qib7 15486 26 FLT3 FLT3 NNP cord-005453-4057qib7 15486 27 gene gene NN cord-005453-4057qib7 15486 28 ( ( -LRB- cord-005453-4057qib7 15486 29 FLT3-ITD FLT3-ITD NNP cord-005453-4057qib7 15486 30 ) ) -RRB- cord-005453-4057qib7 15486 31 in in IN cord-005453-4057qib7 15486 32 October October NNP cord-005453-4057qib7 15486 33 2013 2013 CD cord-005453-4057qib7 15486 34 . . . cord-005453-4057qib7 15487 1 After after IN cord-005453-4057qib7 15487 2 achieving achieve VBG cord-005453-4057qib7 15487 3 complete complete JJ cord-005453-4057qib7 15487 4 remission remission NN cord-005453-4057qib7 15487 5 ( ( -LRB- cord-005453-4057qib7 15487 6 CR cr NN cord-005453-4057qib7 15487 7 ) ) -RRB- cord-005453-4057qib7 15487 8 with with IN cord-005453-4057qib7 15487 9 conventional conventional JJ cord-005453-4057qib7 15487 10 chemotherapy chemotherapy NN cord-005453-4057qib7 15487 11 , , , cord-005453-4057qib7 15487 12 she -PRON- PRP cord-005453-4057qib7 15487 13 received receive VBD cord-005453-4057qib7 15487 14 a a DT cord-005453-4057qib7 15487 15 HLA HLA NNP cord-005453-4057qib7 15487 16 sibling sibling NN cord-005453-4057qib7 15487 17 allogenic allogenic NN cord-005453-4057qib7 15487 18 - - HYPH cord-005453-4057qib7 15487 19 HSCT HSCT NNP cord-005453-4057qib7 15487 20 in in IN cord-005453-4057qib7 15487 21 February February NNP cord-005453-4057qib7 15487 22 2014 2014 CD cord-005453-4057qib7 15487 23 , , , cord-005453-4057qib7 15487 24 with with IN cord-005453-4057qib7 15487 25 BuCy BuCy NNP cord-005453-4057qib7 15487 26 . . . cord-005453-4057qib7 15488 1 Four four CD cord-005453-4057qib7 15488 2 months month NNS cord-005453-4057qib7 15488 3 later later RB cord-005453-4057qib7 15488 4 , , , cord-005453-4057qib7 15488 5 AML AML NNP cord-005453-4057qib7 15488 6 relapsed relapse VBD cord-005453-4057qib7 15488 7 only only RB cord-005453-4057qib7 15488 8 at at IN cord-005453-4057qib7 15488 9 medullary medullary JJ cord-005453-4057qib7 15488 10 level level NN cord-005453-4057qib7 15489 1 ( ( -LRB- cord-005453-4057qib7 15489 2 FLT3 FLT3 NNP cord-005453-4057qib7 15489 3 ratio ratio NN cord-005453-4057qib7 15489 4 : : : cord-005453-4057qib7 15489 5 0,67 0,67 CD cord-005453-4057qib7 15489 6 % % NN cord-005453-4057qib7 15489 7 ) ) -RRB- cord-005453-4057qib7 15489 8 , , , cord-005453-4057qib7 15489 9 treated treat VBN cord-005453-4057qib7 15489 10 with with IN cord-005453-4057qib7 15489 11 chemotherapy chemotherapy NN cord-005453-4057qib7 15489 12 and and CC cord-005453-4057qib7 15489 13 donor donor NN cord-005453-4057qib7 15489 14 lymphocytes lymphocyte NNS cord-005453-4057qib7 15489 15 infusions infusion NNS cord-005453-4057qib7 15489 16 ( ( -LRB- cord-005453-4057qib7 15489 17 DLI DLI NNP cord-005453-4057qib7 15489 18 ) ) -RRB- cord-005453-4057qib7 15489 19 . . . cord-005453-4057qib7 15490 1 She -PRON- PRP cord-005453-4057qib7 15490 2 achieved achieve VBD cord-005453-4057qib7 15490 3 2 2 CD cord-005453-4057qib7 15490 4 nd nd NNP cord-005453-4057qib7 15490 5 CR CR NNP cord-005453-4057qib7 15490 6 and and CC cord-005453-4057qib7 15490 7 developed develop VBD cord-005453-4057qib7 15490 8 limited limited JJ cord-005453-4057qib7 15490 9 chronic chronic JJ cord-005453-4057qib7 15490 10 graft graft NN cord-005453-4057qib7 15490 11 - - HYPH cord-005453-4057qib7 15490 12 versushost versushost NN cord-005453-4057qib7 15490 13 disease disease NN cord-005453-4057qib7 15490 14 ( ( -LRB- cord-005453-4057qib7 15490 15 cGVHD cGVHD NNP cord-005453-4057qib7 15490 16 ) ) -RRB- cord-005453-4057qib7 15490 17 . . . cord-005453-4057qib7 15491 1 Nine nine CD cord-005453-4057qib7 15491 2 months month NNS cord-005453-4057qib7 15491 3 later later RB cord-005453-4057qib7 15491 4 ( ( -LRB- cord-005453-4057qib7 15491 5 April April NNP cord-005453-4057qib7 15491 6 2015 2015 CD cord-005453-4057qib7 15491 7 ) ) -RRB- cord-005453-4057qib7 15491 8 , , , cord-005453-4057qib7 15491 9 she -PRON- PRP cord-005453-4057qib7 15491 10 suffered suffer VBD cord-005453-4057qib7 15491 11 the the DT cord-005453-4057qib7 15491 12 first first JJ cord-005453-4057qib7 15491 13 extramedullary extramedullary JJ cord-005453-4057qib7 15491 14 relapse relapse NN cord-005453-4057qib7 15491 15 only only RB cord-005453-4057qib7 15491 16 , , , cord-005453-4057qib7 15491 17 breast breast NN cord-005453-4057qib7 15491 18 and and CC cord-005453-4057qib7 15491 19 skin skin NN cord-005453-4057qib7 15491 20 . . . cord-005453-4057qib7 15492 1 Disappearance disappearance NN cord-005453-4057qib7 15492 2 of of IN cord-005453-4057qib7 15492 3 the the DT cord-005453-4057qib7 15492 4 lesions lesion NNS cord-005453-4057qib7 15492 5 at at IN cord-005453-4057qib7 15492 6 all all DT cord-005453-4057qib7 15492 7 levels level NNS cord-005453-4057qib7 15492 8 was be VBD cord-005453-4057qib7 15492 9 achieved achieve VBN cord-005453-4057qib7 15492 10 with with IN cord-005453-4057qib7 15492 11 chemo chemo NN cord-005453-4057qib7 15492 12 and and CC cord-005453-4057qib7 15492 13 radiotherapy radiotherapy NN cord-005453-4057qib7 15492 14 . . . cord-005453-4057qib7 15493 1 She -PRON- PRP cord-005453-4057qib7 15493 2 always always RB cord-005453-4057qib7 15493 3 had have VBD cord-005453-4057qib7 15493 4 full full JJ cord-005453-4057qib7 15493 5 hematologic hematologic JJ cord-005453-4057qib7 15493 6 donor donor NN cord-005453-4057qib7 15493 7 chimerism chimerism NN cord-005453-4057qib7 15493 8 . . . cord-005453-4057qib7 15494 1 In in IN cord-005453-4057qib7 15494 2 December December NNP cord-005453-4057qib7 15494 3 2015 2015 CD cord-005453-4057qib7 15494 4 , , , cord-005453-4057qib7 15494 5 she -PRON- PRP cord-005453-4057qib7 15494 6 referred refer VBD cord-005453-4057qib7 15494 7 atypical atypical JJ cord-005453-4057qib7 15494 8 precordial precordial JJ cord-005453-4057qib7 15494 9 pain pain NN cord-005453-4057qib7 15494 10 irradiated irradiate VBN cord-005453-4057qib7 15494 11 to to IN cord-005453-4057qib7 15494 12 the the DT cord-005453-4057qib7 15494 13 back back NN cord-005453-4057qib7 15494 14 . . . cord-005453-4057qib7 15495 1 Cardiac Cardiac NNP cord-005453-4057qib7 15495 2 MRI MRI NNP cord-005453-4057qib7 15495 3 was be VBD cord-005453-4057qib7 15495 4 performed perform VBN cord-005453-4057qib7 15495 5 and and CC cord-005453-4057qib7 15495 6 several several JJ cord-005453-4057qib7 15495 7 masses masse NNS cord-005453-4057qib7 15495 8 were be VBD cord-005453-4057qib7 15495 9 visualized visualize VBN cord-005453-4057qib7 15495 10 in in IN cord-005453-4057qib7 15495 11 the the DT cord-005453-4057qib7 15495 12 pericardial pericardial JJ cord-005453-4057qib7 15495 13 sac sac NN cord-005453-4057qib7 15495 14 , , , cord-005453-4057qib7 15495 15 up up IN cord-005453-4057qib7 15495 16 to to TO cord-005453-4057qib7 15495 17 5 5 CD cord-005453-4057qib7 15495 18 cm cm NNS cord-005453-4057qib7 15495 19 in in IN cord-005453-4057qib7 15495 20 diameter diameter NN cord-005453-4057qib7 15495 21 . . . cord-005453-4057qib7 15496 1 BM BM NNP cord-005453-4057qib7 15496 2 remained remain VBD cord-005453-4057qib7 15496 3 in in IN cord-005453-4057qib7 15496 4 CR CR NNP cord-005453-4057qib7 15496 5 with with IN cord-005453-4057qib7 15496 6 full full JJ cord-005453-4057qib7 15496 7 donor donor NN cord-005453-4057qib7 15496 8 chimerism chimerism NN cord-005453-4057qib7 15496 9 . . . cord-005453-4057qib7 15497 1 Pericardial pericardial JJ cord-005453-4057qib7 15497 2 fluid fluid NN cord-005453-4057qib7 15497 3 showed show VBD cord-005453-4057qib7 15497 4 massive massive JJ cord-005453-4057qib7 15497 5 infiltration infiltration NN cord-005453-4057qib7 15497 6 by by IN cord-005453-4057qib7 15497 7 leukemic leukemic JJ cord-005453-4057qib7 15497 8 - - HYPH cord-005453-4057qib7 15497 9 FLT3 FLT3 NNP cord-005453-4057qib7 15497 10 positive positive JJ cord-005453-4057qib7 15497 11 cells cell NNS cord-005453-4057qib7 15497 12 ( ( -LRB- cord-005453-4057qib7 15497 13 ratio ratio NN cord-005453-4057qib7 15497 14 : : : cord-005453-4057qib7 15497 15 0,7 0,7 CD cord-005453-4057qib7 15497 16 % % NN cord-005453-4057qib7 15497 17 ) ) -RRB- cord-005453-4057qib7 15497 18 . . . cord-005453-4057qib7 15498 1 She -PRON- PRP cord-005453-4057qib7 15498 2 was be VBD cord-005453-4057qib7 15498 3 not not RB cord-005453-4057qib7 15498 4 considered consider VBN cord-005453-4057qib7 15498 5 Background background NN cord-005453-4057qib7 15499 1 : : : cord-005453-4057qib7 15499 2 TA TA NNP cord-005453-4057qib7 15499 3 - - HYPH cord-005453-4057qib7 15499 4 TMA TMA NNP cord-005453-4057qib7 15499 5 is be VBZ cord-005453-4057qib7 15499 6 a a DT cord-005453-4057qib7 15499 7 severe severe JJ cord-005453-4057qib7 15499 8 complication complication NN cord-005453-4057qib7 15499 9 that that WDT cord-005453-4057qib7 15499 10 can can MD cord-005453-4057qib7 15499 11 reduce reduce VB cord-005453-4057qib7 15499 12 survival survival NN cord-005453-4057qib7 15499 13 after after IN cord-005453-4057qib7 15499 14 HSCT HSCT NNP cord-005453-4057qib7 15499 15 . . . cord-005453-4057qib7 15500 1 Risk risk NN cord-005453-4057qib7 15500 2 factors factor NNS cord-005453-4057qib7 15500 3 have have VBP cord-005453-4057qib7 15500 4 been be VBN cord-005453-4057qib7 15500 5 variably variably RB cord-005453-4057qib7 15500 6 reported report VBN cord-005453-4057qib7 15500 7 in in IN cord-005453-4057qib7 15500 8 adults adult NNS cord-005453-4057qib7 15500 9 although although IN cord-005453-4057qib7 15500 10 data datum NNS cord-005453-4057qib7 15500 11 on on IN cord-005453-4057qib7 15500 12 children child NNS cord-005453-4057qib7 15500 13 remains remain VBZ cord-005453-4057qib7 15500 14 scarce scarce JJ cord-005453-4057qib7 15500 15 . . . cord-005453-4057qib7 15501 1 We -PRON- PRP cord-005453-4057qib7 15501 2 aimed aim VBD cord-005453-4057qib7 15501 3 to to TO cord-005453-4057qib7 15501 4 identify identify VB cord-005453-4057qib7 15501 5 a a DT cord-005453-4057qib7 15501 6 risk risk NN cord-005453-4057qib7 15501 7 profile profile NN cord-005453-4057qib7 15501 8 for for IN cord-005453-4057qib7 15501 9 development development NN cord-005453-4057qib7 15501 10 of of IN cord-005453-4057qib7 15501 11 TA TA NNP cord-005453-4057qib7 15501 12 - - HYPH cord-005453-4057qib7 15501 13 TMA TMA NNP cord-005453-4057qib7 15501 14 in in IN cord-005453-4057qib7 15501 15 children child NNS cord-005453-4057qib7 15501 16 undergoing undergo VBG cord-005453-4057qib7 15501 17 HSCT.Methods hsct.method VBZ cord-005453-4057qib7 15501 18 : : : cord-005453-4057qib7 15502 1 We -PRON- PRP cord-005453-4057qib7 15502 2 retrospectively retrospectively RB cord-005453-4057qib7 15502 3 reviewed review VBD cord-005453-4057qib7 15502 4 clinical clinical JJ cord-005453-4057qib7 15502 5 charts chart NNS cord-005453-4057qib7 15502 6 of of IN cord-005453-4057qib7 15502 7 398 398 CD cord-005453-4057qib7 15502 8 children child NNS cord-005453-4057qib7 15502 9 who who WP cord-005453-4057qib7 15502 10 underwent undergo VBD cord-005453-4057qib7 15502 11 406 406 CD cord-005453-4057qib7 15502 12 HSCTs hsct NNS cord-005453-4057qib7 15502 13 between between IN cord-005453-4057qib7 15502 14 2013 2013 CD cord-005453-4057qib7 15502 15 - - SYM cord-005453-4057qib7 15502 16 16 16 CD cord-005453-4057qib7 15502 17 : : : cord-005453-4057qib7 15502 18 at at IN cord-005453-4057qib7 15502 19 Great Great NNP cord-005453-4057qib7 15502 20 Ormond Ormond NNP cord-005453-4057qib7 15502 21 Street Street NNP cord-005453-4057qib7 15502 22 Hospital Hospital NNP cord-005453-4057qib7 15502 23 ( ( -LRB- cord-005453-4057qib7 15502 24 GOSH GOSH NNP cord-005453-4057qib7 15502 25 ) ) -RRB- cord-005453-4057qib7 15502 26 and and CC cord-005453-4057qib7 15502 27 the the DT cord-005453-4057qib7 15502 28 Great Great NNP cord-005453-4057qib7 15502 29 North North NNP cord-005453-4057qib7 15502 30 Children Children NNPS cord-005453-4057qib7 15502 31 's 's POS cord-005453-4057qib7 15502 32 Hospital Hospital NNP cord-005453-4057qib7 15502 33 ( ( -LRB- cord-005453-4057qib7 15502 34 GNCH GNCH NNP cord-005453-4057qib7 15502 35 ) ) -RRB- cord-005453-4057qib7 15502 36 . . . cord-005453-4057qib7 15503 1 TA TA NNP cord-005453-4057qib7 15503 2 - - HYPH cord-005453-4057qib7 15503 3 TMA TMA NNP cord-005453-4057qib7 15503 4 was be VBD cord-005453-4057qib7 15503 5 defined define VBN cord-005453-4057qib7 15503 6 according accord VBG cord-005453-4057qib7 15503 7 to to IN cord-005453-4057qib7 15503 8 revised revise VBN cord-005453-4057qib7 15503 9 criteria criterion NNS cord-005453-4057qib7 15503 10 ( ( -LRB- cord-005453-4057qib7 15503 11 Jodele Jodele NNP cord-005453-4057qib7 15503 12 et et NNP cord-005453-4057qib7 15503 13 al al NNP cord-005453-4057qib7 15503 14 . . NNP cord-005453-4057qib7 15503 15 2013 2013 CD cord-005453-4057qib7 15503 16 ) ) -RRB- cord-005453-4057qib7 15503 17 . . . cord-005453-4057qib7 15504 1 Risk risk NN cord-005453-4057qib7 15504 2 factors factor NNS cord-005453-4057qib7 15504 3 were be VBD cord-005453-4057qib7 15504 4 categorized categorize VBN cord-005453-4057qib7 15504 5 into into IN cord-005453-4057qib7 15504 6 patient patient NN cord-005453-4057qib7 15504 7 derived derive VBN cord-005453-4057qib7 15504 8 [ [ -LRB- cord-005453-4057qib7 15504 9 age age NN cord-005453-4057qib7 15504 10 , , , cord-005453-4057qib7 15504 11 gender gender NN cord-005453-4057qib7 15504 12 , , , cord-005453-4057qib7 15504 13 active active JJ cord-005453-4057qib7 15504 14 co co NN cord-005453-4057qib7 15504 15 - - NN cord-005453-4057qib7 15504 16 morbidity morbidity NN cord-005453-4057qib7 15504 17 at at IN cord-005453-4057qib7 15504 18 D0 d0 NN cord-005453-4057qib7 15504 19 of of IN cord-005453-4057qib7 15504 20 HSCT HSCT NNP cord-005453-4057qib7 15504 21 ( ( -LRB- cord-005453-4057qib7 15504 22 uncontrolled uncontrolled JJ cord-005453-4057qib7 15504 23 viral/ viral/ CD cord-005453-4057qib7 15504 24 bacterial bacterial JJ cord-005453-4057qib7 15504 25 or or CC cord-005453-4057qib7 15504 26 fungal fungal JJ cord-005453-4057qib7 15504 27 infection infection NN cord-005453-4057qib7 15504 28 , , , cord-005453-4057qib7 15504 29 pulmonary pulmonary JJ cord-005453-4057qib7 15504 30 , , , cord-005453-4057qib7 15504 31 cardiovascular cardiovascular JJ cord-005453-4057qib7 15504 32 instability instability NN cord-005453-4057qib7 15504 33 , , , cord-005453-4057qib7 15504 34 steroid steroid NN cord-005453-4057qib7 15504 35 therapy therapy NN cord-005453-4057qib7 15504 36 > > XX cord-005453-4057qib7 15505 1 0.3mg 0.3mg LS cord-005453-4057qib7 15505 2 / / SYM cord-005453-4057qib7 15505 3 kg kg NNS cord-005453-4057qib7 15505 4 beyond beyond IN cord-005453-4057qib7 15505 5 D0 d0 NN cord-005453-4057qib7 15505 6 , , , cord-005453-4057qib7 15505 7 BCGiosis BCGiosis NNP cord-005453-4057qib7 15505 8 or or CC cord-005453-4057qib7 15505 9 autoimmune autoimmune JJ cord-005453-4057qib7 15505 10 disease disease NN cord-005453-4057qib7 15505 11 ) ) -RRB- cord-005453-4057qib7 15505 12 , , , cord-005453-4057qib7 15505 13 transplant transplant NN cord-005453-4057qib7 15505 14 related relate VBN cord-005453-4057qib7 15505 15 factors factor NNS cord-005453-4057qib7 15505 16 ( ( -LRB- cord-005453-4057qib7 15505 17 conditioning conditioning NN cord-005453-4057qib7 15505 18 intensity intensity NN cord-005453-4057qib7 15505 19 , , , cord-005453-4057qib7 15505 20 stem stem NN cord-005453-4057qib7 15505 21 cell cell NN cord-005453-4057qib7 15505 22 source source NN cord-005453-4057qib7 15505 23 , , , cord-005453-4057qib7 15505 24 HLA HLA NNP cord-005453-4057qib7 15505 25 - - HYPH cord-005453-4057qib7 15505 26 matching matching NN cord-005453-4057qib7 15505 27 , , , cord-005453-4057qib7 15505 28 use use NN cord-005453-4057qib7 15505 29 of of IN cord-005453-4057qib7 15505 30 Ciclosporin Ciclosporin NNP cord-005453-4057qib7 15505 31 A A NNP cord-005453-4057qib7 15505 32 ( ( -LRB- cord-005453-4057qib7 15505 33 CSA CSA NNP cord-005453-4057qib7 15505 34 ) ) -RRB- cord-005453-4057qib7 15505 35 or or CC cord-005453-4057qib7 15505 36 Tacrolimus Tacrolimus NNP cord-005453-4057qib7 15505 37 ( ( -LRB- cord-005453-4057qib7 15505 38 Tac Tac NNP cord-005453-4057qib7 15505 39 ) ) -RRB- cord-005453-4057qib7 15505 40 , , , cord-005453-4057qib7 15505 41 CD34 CD34 NNP cord-005453-4057qib7 15505 42 + + CC cord-005453-4057qib7 15505 43 dose dose NN cord-005453-4057qib7 15505 44 , , , cord-005453-4057qib7 15505 45 ex ex JJ cord-005453-4057qib7 15505 46 - - JJ cord-005453-4057qib7 15505 47 vivo vivo JJ cord-005453-4057qib7 15505 48 T t NN cord-005453-4057qib7 15505 49 cell cell NN cord-005453-4057qib7 15505 50 depletion depletion NN cord-005453-4057qib7 15505 51 , , , cord-005453-4057qib7 15505 52 use use NN cord-005453-4057qib7 15505 53 of of IN cord-005453-4057qib7 15505 54 Defibrotide Defibrotide NNP cord-005453-4057qib7 15505 55 ) ) -RRB- cord-005453-4057qib7 15505 56 and and CC cord-005453-4057qib7 15505 57 post post JJ cord-005453-4057qib7 15505 58 - - JJ cord-005453-4057qib7 15505 59 HSCT hsct JJ cord-005453-4057qib7 15505 60 factors factor NNS cord-005453-4057qib7 15505 61 ( ( -LRB- cord-005453-4057qib7 15505 62 aGvHD agvhd NN cord-005453-4057qib7 15505 63 , , , cord-005453-4057qib7 15505 64 post post JJ cord-005453-4057qib7 15505 65 - - JJ cord-005453-4057qib7 15505 66 HSCT hsct JJ cord-005453-4057qib7 15505 67 viral viral JJ cord-005453-4057qib7 15505 68 reactivation reactivation NN cord-005453-4057qib7 15505 69 , , , cord-005453-4057qib7 15505 70 venoocclusive venoocclusive JJ cord-005453-4057qib7 15505 71 disease disease NN cord-005453-4057qib7 15505 72 ( ( -LRB- cord-005453-4057qib7 15505 73 VOD VOD NNP cord-005453-4057qib7 15505 74 ) ) -RRB- cord-005453-4057qib7 15505 75 and and CC cord-005453-4057qib7 15505 76 occurrence occurrence NN cord-005453-4057qib7 15505 77 of of IN cord-005453-4057qib7 15505 78 posterior posterior JJ cord-005453-4057qib7 15505 79 reversible reversible JJ cord-005453-4057qib7 15505 80 leukoencephalopathy leukoencephalopathy NNS cord-005453-4057qib7 15505 81 ( ( -LRB- cord-005453-4057qib7 15505 82 PRES).Results PRES).Results NNP cord-005453-4057qib7 15505 83 : : : cord-005453-4057qib7 15506 1 At at IN cord-005453-4057qib7 15506 2 a a DT cord-005453-4057qib7 15506 3 median median NN cord-005453-4057qib7 15506 4 of of IN cord-005453-4057qib7 15506 5 7 7 CD cord-005453-4057qib7 15506 6 months month NNS cord-005453-4057qib7 15506 7 post post JJ cord-005453-4057qib7 15506 8 - - JJ cord-005453-4057qib7 15506 9 HSCT HSCT NNP cord-005453-4057qib7 15506 10 , , , cord-005453-4057qib7 15506 11 TA TA NNP cord-005453-4057qib7 15506 12 - - HYPH cord-005453-4057qib7 15506 13 TMA TMA NNP cord-005453-4057qib7 15506 14 occurred occur VBD cord-005453-4057qib7 15506 15 among among IN cord-005453-4057qib7 15506 16 21/406 21/406 CD cord-005453-4057qib7 15506 17 transplants transplant NNS cord-005453-4057qib7 15506 18 ( ( -LRB- cord-005453-4057qib7 15506 19 5.1 5.1 CD cord-005453-4057qib7 15506 20 % % NN cord-005453-4057qib7 15506 21 ) ) -RRB- cord-005453-4057qib7 15506 22 . . . cord-005453-4057qib7 15507 1 There there EX cord-005453-4057qib7 15507 2 was be VBD cord-005453-4057qib7 15507 3 no no DT cord-005453-4057qib7 15507 4 reported report VBN cord-005453-4057qib7 15507 5 centre centre NN cord-005453-4057qib7 15507 6 variation variation NN cord-005453-4057qib7 15507 7 ( ( -LRB- cord-005453-4057qib7 15507 8 5.7 5.7 CD cord-005453-4057qib7 15507 9 % % NN cord-005453-4057qib7 15507 10 vs vs IN cord-005453-4057qib7 15507 11 4.6 4.6 CD cord-005453-4057qib7 15507 12 % % NN cord-005453-4057qib7 15507 13 in in IN cord-005453-4057qib7 15507 14 GOSH GOSH NNP cord-005453-4057qib7 15507 15 vs vs IN cord-005453-4057qib7 15507 16 GNCH GNCH NNP cord-005453-4057qib7 15507 17 ; ; : cord-005453-4057qib7 15507 18 p=0.6 p=0.6 NNP cord-005453-4057qib7 15507 19 ) ) -RRB- cord-005453-4057qib7 15507 20 . . . cord-005453-4057qib7 15508 1 Gender gender NN cord-005453-4057qib7 15508 2 , , , cord-005453-4057qib7 15508 3 underlying underlie VBG cord-005453-4057qib7 15508 4 disease disease NN cord-005453-4057qib7 15508 5 -primary -primary JJ cord-005453-4057qib7 15508 6 immune immune JJ cord-005453-4057qib7 15508 7 deficiency deficiency NN cord-005453-4057qib7 15508 8 ( ( -LRB- cord-005453-4057qib7 15508 9 PID PID NNP cord-005453-4057qib7 15508 10 ) ) -RRB- cord-005453-4057qib7 15508 11 ( ( -LRB- cord-005453-4057qib7 15508 12 n=273 n=273 NNP cord-005453-4057qib7 15508 13 ) ) -RRB- cord-005453-4057qib7 15508 14 vs vs IN cord-005453-4057qib7 15508 15 haematological haematological NN cord-005453-4057qib7 15508 16 disease disease NN cord-005453-4057qib7 15508 17 ( ( -LRB- cord-005453-4057qib7 15508 18 n=133 n=133 NNP cord-005453-4057qib7 15508 19 ) ) -RRB- cord-005453-4057qib7 15508 20 , , , cord-005453-4057qib7 15508 21 use use NN cord-005453-4057qib7 15508 22 of of IN cord-005453-4057qib7 15508 23 myeloablative myeloablative NNP cord-005453-4057qib7 15508 24 ( ( -LRB- cord-005453-4057qib7 15508 25 n=153 n=153 NNP cord-005453-4057qib7 15508 26 ) ) -RRB- cord-005453-4057qib7 15508 27 vs vs IN cord-005453-4057qib7 15508 28 reducedor reducedor JJ cord-005453-4057qib7 15508 29 minimal minimal JJ cord-005453-4057qib7 15508 30 intensity intensity NN cord-005453-4057qib7 15508 31 conditioning conditioning NN cord-005453-4057qib7 15508 32 ( ( -LRB- cord-005453-4057qib7 15508 33 n=229 n=229 NNP cord-005453-4057qib7 15508 34 ) ) -RRB- cord-005453-4057qib7 15508 35 , , , cord-005453-4057qib7 15508 36 use use NN cord-005453-4057qib7 15508 37 of of IN cord-005453-4057qib7 15508 38 serotherapy serotherapy NN cord-005453-4057qib7 15508 39 or or CC cord-005453-4057qib7 15508 40 mega mega JJ cord-005453-4057qib7 15508 41 doses dose NNS cord-005453-4057qib7 15508 42 of of IN cord-005453-4057qib7 15508 43 CD34 CD34 NNP cord-005453-4057qib7 15508 44 ≥10 ≥10 NNP cord-005453-4057qib7 15508 45 X10 X10 NNP cord-005453-4057qib7 15508 46 * * NFP cord-005453-4057qib7 15508 47 6 6 CD cord-005453-4057qib7 15508 48 / / SYM cord-005453-4057qib7 15508 49 Kg Kg NNP cord-005453-4057qib7 15508 50 did do VBD cord-005453-4057qib7 15508 51 not not RB cord-005453-4057qib7 15508 52 influence influence VB cord-005453-4057qib7 15508 53 the the DT cord-005453-4057qib7 15508 54 development development NN cord-005453-4057qib7 15508 55 of of IN cord-005453-4057qib7 15508 56 TA TA NNP cord-005453-4057qib7 15508 57 - - HYPH cord-005453-4057qib7 15508 58 TMA TMA NNP cord-005453-4057qib7 15508 59 . . . cord-005453-4057qib7 15509 1 Donor donor NN cord-005453-4057qib7 15509 2 type type NN cord-005453-4057qib7 15509 3 : : : cord-005453-4057qib7 15509 4 MSD/ MSD/ NNP cord-005453-4057qib7 15509 5 MFD(n=100 MFD(n=100 NNP cord-005453-4057qib7 15509 6 ) ) -RRB- cord-005453-4057qib7 15509 7 vs vs IN cord-005453-4057qib7 15509 8 MUD MUD NNP cord-005453-4057qib7 15509 9 ( ( -LRB- cord-005453-4057qib7 15509 10 n=129 n=129 NNP cord-005453-4057qib7 15509 11 ) ) -RRB- cord-005453-4057qib7 15509 12 vs vs IN cord-005453-4057qib7 15509 13 MMUD MMUD NNP cord-005453-4057qib7 15509 14 / / SYM cord-005453-4057qib7 15509 15 Haplo Haplo NNP cord-005453-4057qib7 15509 16 - - HYPH cord-005453-4057qib7 15509 17 HSCT HSCT NNP cord-005453-4057qib7 15509 18 Background Background NNP cord-005453-4057qib7 15510 1 : : : cord-005453-4057qib7 15510 2 We -PRON- PRP cord-005453-4057qib7 15510 3 evaluated evaluate VBD cord-005453-4057qib7 15510 4 the the DT cord-005453-4057qib7 15510 5 outcome outcome NN cord-005453-4057qib7 15510 6 of of IN cord-005453-4057qib7 15510 7 haploidentical haploidentical JJ cord-005453-4057qib7 15510 8 HCT HCT NNP cord-005453-4057qib7 15510 9 ( ( -LRB- cord-005453-4057qib7 15510 10 HHCT HHCT NNP cord-005453-4057qib7 15510 11 ) ) -RRB- cord-005453-4057qib7 15510 12 using use VBG cord-005453-4057qib7 15510 13 ex ex FW cord-005453-4057qib7 15510 14 vivo vivo FW cord-005453-4057qib7 15510 15 αβ αβ FW cord-005453-4057qib7 15510 16 T t NN cord-005453-4057qib7 15510 17 cell cell NN cord-005453-4057qib7 15510 18 - - HYPH cord-005453-4057qib7 15510 19 depleted deplete VBN cord-005453-4057qib7 15510 20 ( ( -LRB- cord-005453-4057qib7 15510 21 TCD TCD NNP cord-005453-4057qib7 15510 22 ) ) -RRB- cord-005453-4057qib7 15510 23 grafts graft NNS cord-005453-4057qib7 15510 24 after after IN cord-005453-4057qib7 15510 25 reduced reduce VBN cord-005453-4057qib7 15510 26 - - HYPH cord-005453-4057qib7 15510 27 intensity intensity NN cord-005453-4057qib7 15510 28 conditioning conditioning NN cord-005453-4057qib7 15510 29 ( ( -LRB- cord-005453-4057qib7 15510 30 RIC RIC NNP cord-005453-4057qib7 15510 31 ) ) -RRB- cord-005453-4057qib7 15510 32 containing contain VBG cord-005453-4057qib7 15510 33 low low JJ cord-005453-4057qib7 15510 34 - - HYPH cord-005453-4057qib7 15510 35 dose dose NN cord-005453-4057qib7 15510 36 TBI TBI NNP cord-005453-4057qib7 15510 37 ( ( -LRB- cord-005453-4057qib7 15510 38 LD LD NNP cord-005453-4057qib7 15510 39 - - HYPH cord-005453-4057qib7 15510 40 TBI TBI NNP cord-005453-4057qib7 15510 41 ) ) -RRB- cord-005453-4057qib7 15510 42 in in IN cord-005453-4057qib7 15510 43 pediatric pediatric JJ cord-005453-4057qib7 15510 44 patients patient NNS cord-005453-4057qib7 15510 45 with with IN cord-005453-4057qib7 15510 46 acute acute JJ cord-005453-4057qib7 15510 47 leukemia leukemia NN cord-005453-4057qib7 15510 48 ( ( -LRB- cord-005453-4057qib7 15510 49 AL AL NNP cord-005453-4057qib7 15510 50 ) ) -RRB- cord-005453-4057qib7 15510 51 in in IN cord-005453-4057qib7 15510 52 complete complete JJ cord-005453-4057qib7 15510 53 remission remission NN cord-005453-4057qib7 15510 54 ( ( -LRB- cord-005453-4057qib7 15510 55 CR).Methods cr).method NNS cord-005453-4057qib7 15510 56 : : : cord-005453-4057qib7 15510 57 Between between IN cord-005453-4057qib7 15510 58 May May NNP cord-005453-4057qib7 15510 59 2012 2012 CD cord-005453-4057qib7 15510 60 and and CC cord-005453-4057qib7 15510 61 October October NNP cord-005453-4057qib7 15510 62 2018 2018 CD cord-005453-4057qib7 15510 63 , , , cord-005453-4057qib7 15510 64 36 36 CD cord-005453-4057qib7 15510 65 patients patient NNS cord-005453-4057qib7 15510 66 with with IN cord-005453-4057qib7 15510 67 acute acute JJ cord-005453-4057qib7 15510 68 leukemia leukemia NN cord-005453-4057qib7 15510 69 ( ( -LRB- cord-005453-4057qib7 15510 70 17 17 CD cord-005453-4057qib7 15510 71 ALL all DT cord-005453-4057qib7 15510 72 and and CC cord-005453-4057qib7 15510 73 19 19 CD cord-005453-4057qib7 15510 74 AML AML NNP cord-005453-4057qib7 15510 75 ) ) -RRB- cord-005453-4057qib7 15510 76 in in IN cord-005453-4057qib7 15510 77 CR CR NNP cord-005453-4057qib7 15510 78 received receive VBD cord-005453-4057qib7 15510 79 haploidentical haploidentical JJ cord-005453-4057qib7 15510 80 hematopoietic hematopoietic JJ cord-005453-4057qib7 15510 81 cell cell NN cord-005453-4057qib7 15510 82 transplantation transplantation NN cord-005453-4057qib7 15510 83 ( ( -LRB- cord-005453-4057qib7 15510 84 HHCT HHCT NNP cord-005453-4057qib7 15510 85 ) ) -RRB- cord-005453-4057qib7 15510 86 using use VBG cord-005453-4057qib7 15510 87 TCRαβ TCRαβ NNP cord-005453-4057qib7 15510 88 - - HYPH cord-005453-4057qib7 15510 89 depleted deplete VBN cord-005453-4057qib7 15510 90 graft graft NN cord-005453-4057qib7 15510 91 at at IN cord-005453-4057qib7 15510 92 Asan Asan NNP cord-005453-4057qib7 15510 93 Medical Medical NNP cord-005453-4057qib7 15510 94 Center Center NNP cord-005453-4057qib7 15510 95 Children Children NNPS cord-005453-4057qib7 15510 96 's 's POS cord-005453-4057qib7 15510 97 Hospital Hospital NNP cord-005453-4057qib7 15510 98 . . . cord-005453-4057qib7 15511 1 Eighteen eighteen CD cord-005453-4057qib7 15511 2 patients patient NNS cord-005453-4057qib7 15511 3 received receive VBD cord-005453-4057qib7 15511 4 HHCT HHCT NNP cord-005453-4057qib7 15511 5 between between IN cord-005453-4057qib7 15511 6 2012 2012 CD cord-005453-4057qib7 15511 7 and and CC cord-005453-4057qib7 15511 8 2015 2015 CD cord-005453-4057qib7 15511 9 ( ( -LRB- cord-005453-4057qib7 15511 10 earlier early JJR cord-005453-4057qib7 15511 11 time time NN cord-005453-4057qib7 15511 12 period period NN cord-005453-4057qib7 15511 13 ) ) -RRB- cord-005453-4057qib7 15511 14 and and CC cord-005453-4057qib7 15511 15 the the DT cord-005453-4057qib7 15511 16 remaining remain VBG cord-005453-4057qib7 15511 17 18 18 CD cord-005453-4057qib7 15511 18 between between IN cord-005453-4057qib7 15511 19 2016 2016 CD cord-005453-4057qib7 15511 20 and and CC cord-005453-4057qib7 15511 21 2018 2018 CD cord-005453-4057qib7 15511 22 ( ( -LRB- cord-005453-4057qib7 15511 23 recent recent JJ cord-005453-4057qib7 15511 24 study study NN cord-005453-4057qib7 15511 25 period period NN cord-005453-4057qib7 15511 26 ) ) -RRB- cord-005453-4057qib7 15511 27 . . . cord-005453-4057qib7 15512 1 The the DT cord-005453-4057qib7 15512 2 conditioning conditioning NN cord-005453-4057qib7 15512 3 regimens regimen NNS cord-005453-4057qib7 15512 4 , , , cord-005453-4057qib7 15512 5 the the DT cord-005453-4057qib7 15512 6 dose dose NN cord-005453-4057qib7 15512 7 of of IN cord-005453-4057qib7 15512 8 αβ+ αβ+ NN cord-005453-4057qib7 15512 9 T t NN cord-005453-4057qib7 15512 10 cells cell NNS cord-005453-4057qib7 15512 11 and and CC cord-005453-4057qib7 15512 12 GVHD GVHD NNP cord-005453-4057qib7 15512 13 prophylaxis prophylaxis NN cord-005453-4057qib7 15512 14 are be VBP cord-005453-4057qib7 15512 15 summarized summarize VBN cord-005453-4057qib7 15512 16 in in IN cord-005453-4057qib7 15512 17 Table Table NNP cord-005453-4057qib7 15512 18 . . . cord-005453-4057qib7 15513 1 Results result NNS cord-005453-4057qib7 15513 2 : : : cord-005453-4057qib7 15514 1 All all DT cord-005453-4057qib7 15514 2 36 36 CD cord-005453-4057qib7 15514 3 patients patient NNS cord-005453-4057qib7 15514 4 achieved achieve VBD cord-005453-4057qib7 15514 5 a a DT cord-005453-4057qib7 15514 6 sustained sustained JJ cord-005453-4057qib7 15514 7 neutrophil neutrophil NN cord-005453-4057qib7 15514 8 engraftment engraftment NN cord-005453-4057qib7 15514 9 at at IN cord-005453-4057qib7 15514 10 a a DT cord-005453-4057qib7 15514 11 median median NN cord-005453-4057qib7 15514 12 of of IN cord-005453-4057qib7 15514 13 10 10 CD cord-005453-4057qib7 15514 14 days day NNS cord-005453-4057qib7 15514 15 ( ( -LRB- cord-005453-4057qib7 15514 16 range range NN cord-005453-4057qib7 15514 17 , , , cord-005453-4057qib7 15514 18 9 9 CD cord-005453-4057qib7 15514 19 - - SYM cord-005453-4057qib7 15514 20 13 13 CD cord-005453-4057qib7 15514 21 ) ) -RRB- cord-005453-4057qib7 15514 22 . . . cord-005453-4057qib7 15515 1 Of of IN cord-005453-4057qib7 15515 2 36 36 CD cord-005453-4057qib7 15515 3 patients patient NNS cord-005453-4057qib7 15515 4 , , , cord-005453-4057qib7 15515 5 11 11 CD cord-005453-4057qib7 15515 6 patients patient NNS cord-005453-4057qib7 15515 7 ( ( -LRB- cord-005453-4057qib7 15515 8 8 8 CD cord-005453-4057qib7 15515 9 ALL all DT cord-005453-4057qib7 15515 10 & & CC cord-005453-4057qib7 15515 11 4 4 CD cord-005453-4057qib7 15515 12 AML AML NNP cord-005453-4057qib7 15515 13 ) ) -RRB- cord-005453-4057qib7 15515 14 relapsed relapse VBD cord-005453-4057qib7 15515 15 at at IN cord-005453-4057qib7 15515 16 a a DT cord-005453-4057qib7 15515 17 median median NN cord-005453-4057qib7 15515 18 of of IN cord-005453-4057qib7 15515 19 6 6 CD cord-005453-4057qib7 15515 20 months month NNS cord-005453-4057qib7 15515 21 ( ( -LRB- cord-005453-4057qib7 15515 22 range range NN cord-005453-4057qib7 15515 23 , , , cord-005453-4057qib7 15515 24 3 3 CD cord-005453-4057qib7 15515 25 - - SYM cord-005453-4057qib7 15515 26 16 16 CD cord-005453-4057qib7 15515 27 ) ) -RRB- cord-005453-4057qib7 15515 28 after after IN cord-005453-4057qib7 15515 29 transplant transplant NN cord-005453-4057qib7 15515 30 . . . cord-005453-4057qib7 15516 1 Of of IN cord-005453-4057qib7 15516 2 the the DT cord-005453-4057qib7 15516 3 11 11 CD cord-005453-4057qib7 15516 4 patients patient NNS cord-005453-4057qib7 15516 5 , , , cord-005453-4057qib7 15516 6 10 10 CD cord-005453-4057qib7 15516 7 patients patient NNS cord-005453-4057qib7 15516 8 died die VBD cord-005453-4057qib7 15516 9 of of IN cord-005453-4057qib7 15516 10 disease disease NN cord-005453-4057qib7 15516 11 . . . cord-005453-4057qib7 15517 1 One one CD cord-005453-4057qib7 15517 2 patient patient NN cord-005453-4057qib7 15517 3 died die VBD cord-005453-4057qib7 15517 4 of of IN cord-005453-4057qib7 15517 5 disseminated disseminate VBN cord-005453-4057qib7 15517 6 tuberculosis tuberculosis NN cord-005453-4057qib7 15517 7 at at IN cord-005453-4057qib7 15517 8 11 11 CD cord-005453-4057qib7 15517 9 months month NNS cord-005453-4057qib7 15517 10 after after IN cord-005453-4057qib7 15517 11 transplant transplant NN cord-005453-4057qib7 15517 12 , , , cord-005453-4057qib7 15517 13 leading lead VBG cord-005453-4057qib7 15517 14 to to IN cord-005453-4057qib7 15517 15 the the DT cord-005453-4057qib7 15517 16 TRM TRM NNP cord-005453-4057qib7 15517 17 of of IN cord-005453-4057qib7 15517 18 4 4 CD cord-005453-4057qib7 15517 19 % % NN cord-005453-4057qib7 15517 20 at at IN cord-005453-4057qib7 15517 21 1 1 CD cord-005453-4057qib7 15517 22 year year NN cord-005453-4057qib7 15517 23 . . . cord-005453-4057qib7 15518 1 As as IN cord-005453-4057qib7 15518 2 of of IN cord-005453-4057qib7 15518 3 December December NNP cord-005453-4057qib7 15518 4 2018 2018 CD cord-005453-4057qib7 15518 5 , , , cord-005453-4057qib7 15518 6 25 25 CD cord-005453-4057qib7 15518 7 of of IN cord-005453-4057qib7 15518 8 the the DT cord-005453-4057qib7 15518 9 36 36 CD cord-005453-4057qib7 15518 10 patients patient NNS cord-005453-4057qib7 15518 11 survive survive VBP cord-005453-4057qib7 15518 12 free free JJ cord-005453-4057qib7 15518 13 of of IN cord-005453-4057qib7 15518 14 disease disease NN cord-005453-4057qib7 15518 15 at at IN cord-005453-4057qib7 15518 16 a a DT cord-005453-4057qib7 15518 17 median median JJ cord-005453-4057qib7 15518 18 follow follow NN cord-005453-4057qib7 15518 19 - - HYPH cord-005453-4057qib7 15518 20 up up NN cord-005453-4057qib7 15518 21 of of IN cord-005453-4057qib7 15518 22 21 21 CD cord-005453-4057qib7 15518 23 months month NNS cord-005453-4057qib7 15518 24 ( ( -LRB- cord-005453-4057qib7 15518 25 range range NN cord-005453-4057qib7 15518 26 , , , cord-005453-4057qib7 15518 27 . . . cord-005453-4057qib7 15519 1 At at IN cord-005453-4057qib7 15519 2 a a DT cord-005453-4057qib7 15519 3 median median JJ cord-005453-4057qib7 15519 4 followup followup NN cord-005453-4057qib7 15519 5 of of IN cord-005453-4057qib7 15519 6 35 35 CD cord-005453-4057qib7 15519 7 months month NNS cord-005453-4057qib7 15519 8 ( ( -LRB- cord-005453-4057qib7 15519 9 range range NN cord-005453-4057qib7 15519 10 , , , cord-005453-4057qib7 15519 11 1 1 CD cord-005453-4057qib7 15519 12 - - SYM cord-005453-4057qib7 15519 13 80 80 CD cord-005453-4057qib7 15519 14 ) ) -RRB- cord-005453-4057qib7 15519 15 , , , cord-005453-4057qib7 15519 16 EFS EFS NNP cord-005453-4057qib7 15519 17 and and CC cord-005453-4057qib7 15519 18 OS os NN cord-005453-4057qib7 15519 19 at at IN cord-005453-4057qib7 15519 20 2 2 CD cord-005453-4057qib7 15519 21 years year NNS cord-005453-4057qib7 15519 22 for for IN cord-005453-4057qib7 15519 23 all all DT cord-005453-4057qib7 15519 24 patients patient NNS cord-005453-4057qib7 15519 25 were be VBD cord-005453-4057qib7 15519 26 59 59 CD cord-005453-4057qib7 15519 27 % % NN cord-005453-4057qib7 15519 28 and and CC cord-005453-4057qib7 15519 29 67 67 CD cord-005453-4057qib7 15519 30 % % NN cord-005453-4057qib7 15519 31 , , , cord-005453-4057qib7 15519 32 respectively respectively RB cord-005453-4057qib7 15519 33 . . . cord-005453-4057qib7 15520 1 Outcome outcome NN cord-005453-4057qib7 15520 2 of of IN cord-005453-4057qib7 15520 3 HHCT HHCT NNP cord-005453-4057qib7 15520 4 in in IN cord-005453-4057qib7 15520 5 the the DT cord-005453-4057qib7 15520 6 recent recent JJ cord-005453-4057qib7 15520 7 study study NN cord-005453-4057qib7 15520 8 cohort cohort NN cord-005453-4057qib7 15520 9 was be VBD cord-005453-4057qib7 15520 10 significantly significantly RB cord-005453-4057qib7 15520 11 better well JJR cord-005453-4057qib7 15520 12 than than IN cord-005453-4057qib7 15520 13 that that DT cord-005453-4057qib7 15520 14 in in IN cord-005453-4057qib7 15520 15 the the DT cord-005453-4057qib7 15520 16 earlier early JJR cord-005453-4057qib7 15520 17 study study NN cord-005453-4057qib7 15520 18 period period NN cord-005453-4057qib7 15520 19 ( ( -LRB- cord-005453-4057qib7 15520 20 EFS efs NN cord-005453-4057qib7 15520 21 of of IN cord-005453-4057qib7 15520 22 85 85 CD cord-005453-4057qib7 15520 23 % % NN cord-005453-4057qib7 15520 24 vs vs IN cord-005453-4057qib7 15520 25 EFS EFS NNP cord-005453-4057qib7 15520 26 of of IN cord-005453-4057qib7 15520 27 44 44 CD cord-005453-4057qib7 15520 28 % % NN cord-005453-4057qib7 15520 29 , , , cord-005453-4057qib7 15520 30 P=0.05 p=0.05 JJ cord-005453-4057qib7 15520 31 ) ) -RRB- cord-005453-4057qib7 15520 32 . . . cord-005453-4057qib7 15521 1 Among among IN cord-005453-4057qib7 15521 2 the the DT cord-005453-4057qib7 15521 3 17 17 CD cord-005453-4057qib7 15521 4 patients patient NNS cord-005453-4057qib7 15521 5 with with IN cord-005453-4057qib7 15521 6 ALL all DT cord-005453-4057qib7 15521 7 , , , cord-005453-4057qib7 15521 8 the the DT cord-005453-4057qib7 15521 9 EFS efs NN cord-005453-4057qib7 15521 10 of of IN cord-005453-4057qib7 15521 11 8 8 CD cord-005453-4057qib7 15521 12 patients patient NNS cord-005453-4057qib7 15521 13 , , , cord-005453-4057qib7 15521 14 who who WP cord-005453-4057qib7 15521 15 received receive VBD cord-005453-4057qib7 15521 16 HHCT HHCT NNP cord-005453-4057qib7 15521 17 in in IN cord-005453-4057qib7 15521 18 early early JJ cord-005453-4057qib7 15521 19 time time NN cord-005453-4057qib7 15521 20 period period NN cord-005453-4057qib7 15521 21 after after IN cord-005453-4057qib7 15521 22 conditioning conditioning NN cord-005453-4057qib7 15521 23 with with IN cord-005453-4057qib7 15521 24 TBI TBI NNP cord-005453-4057qib7 15521 25 of of IN cord-005453-4057qib7 15521 26 600 600 CD cord-005453-4057qib7 15521 27 cGy cGy NNS cord-005453-4057qib7 15521 28 , , , cord-005453-4057qib7 15521 29 was be VBD cord-005453-4057qib7 15521 30 significantly significantly RB cord-005453-4057qib7 15521 31 worse bad JJR cord-005453-4057qib7 15521 32 than than IN cord-005453-4057qib7 15521 33 that that DT cord-005453-4057qib7 15521 34 of of IN cord-005453-4057qib7 15521 35 9 9 CD cord-005453-4057qib7 15521 36 patients patient NNS cord-005453-4057qib7 15521 37 , , , cord-005453-4057qib7 15521 38 who who WP cord-005453-4057qib7 15521 39 received receive VBD cord-005453-4057qib7 15521 40 in in IN cord-005453-4057qib7 15521 41 recent recent JJ cord-005453-4057qib7 15521 42 study study NN cord-005453-4057qib7 15521 43 period period NN cord-005453-4057qib7 15521 44 after after IN cord-005453-4057qib7 15521 45 a a DT cord-005453-4057qib7 15521 46 higher high JJR cord-005453-4057qib7 15521 47 dose dose NN cord-005453-4057qib7 15521 48 of of IN cord-005453-4057qib7 15521 49 TBI TBI NNP cord-005453-4057qib7 15521 50 at at IN cord-005453-4057qib7 15521 51 800cGy 800cgy CD cord-005453-4057qib7 15521 52 ( ( -LRB- cord-005453-4057qib7 15521 53 13 13 CD cord-005453-4057qib7 15521 54 % % NN cord-005453-4057qib7 15521 55 vs vs IN cord-005453-4057qib7 15521 56 83 83 CD cord-005453-4057qib7 15521 57 % % NN cord-005453-4057qib7 15521 58 , , , cord-005453-4057qib7 15521 59 P p NN cord-005453-4057qib7 15521 60 < < XX cord-005453-4057qib7 15521 61 0.05 0.05 CD cord-005453-4057qib7 15521 62 ) ) -RRB- cord-005453-4057qib7 15521 63 . . . cord-005453-4057qib7 15522 1 The the DT cord-005453-4057qib7 15522 2 EFSs efs NNS cord-005453-4057qib7 15522 3 of of IN cord-005453-4057qib7 15522 4 AML AML NNP cord-005453-4057qib7 15522 5 were be VBD cord-005453-4057qib7 15522 6 similar similar JJ cord-005453-4057qib7 15522 7 between between IN cord-005453-4057qib7 15522 8 the the DT cord-005453-4057qib7 15522 9 two two CD cord-005453-4057qib7 15522 10 study study NN cord-005453-4057qib7 15522 11 groups group NNS cord-005453-4057qib7 15522 12 ( ( -LRB- cord-005453-4057qib7 15522 13 70 70 CD cord-005453-4057qib7 15522 14 % % NN cord-005453-4057qib7 15522 15 for for IN cord-005453-4057qib7 15522 16 earlier early JJR cord-005453-4057qib7 15522 17 cohort cohort NN cord-005453-4057qib7 15522 18 vs vs IN cord-005453-4057qib7 15522 19 86 86 CD cord-005453-4057qib7 15522 20 % % NN cord-005453-4057qib7 15522 21 for for IN cord-005453-4057qib7 15522 22 recent recent JJ cord-005453-4057qib7 15522 23 study study NN cord-005453-4057qib7 15522 24 , , , cord-005453-4057qib7 15522 25 P>0.05).Conclusions p>0.05).conclusion NNS cord-005453-4057qib7 15522 26 : : : cord-005453-4057qib7 15523 1 In in IN cord-005453-4057qib7 15523 2 pediatric pediatric JJ cord-005453-4057qib7 15523 3 patients patient NNS cord-005453-4057qib7 15523 4 with with IN cord-005453-4057qib7 15523 5 acute acute JJ cord-005453-4057qib7 15523 6 leukemia leukemia NN cord-005453-4057qib7 15523 7 in in IN cord-005453-4057qib7 15523 8 CR CR NNP cord-005453-4057qib7 15523 9 , , , cord-005453-4057qib7 15523 10 our -PRON- PRP$ cord-005453-4057qib7 15523 11 current current JJ cord-005453-4057qib7 15523 12 haploidentical haploidentical JJ cord-005453-4057qib7 15523 13 HCT hct NN cord-005453-4057qib7 15523 14 using use VBG cord-005453-4057qib7 15523 15 ex ex FW cord-005453-4057qib7 15523 16 vivo vivo FW cord-005453-4057qib7 15523 17 αβ αβ FW cord-005453-4057qib7 15523 18 TCD TCD NNP cord-005453-4057qib7 15523 19 graft graft NN cord-005453-4057qib7 15523 20 after after IN cord-005453-4057qib7 15523 21 RIC RIC NNP cord-005453-4057qib7 15523 22 containing contain VBG cord-005453-4057qib7 15523 23 LD LD NNP cord-005453-4057qib7 15523 24 - - HYPH cord-005453-4057qib7 15523 25 TBI TBI NNP cord-005453-4057qib7 15523 26 without without IN cord-005453-4057qib7 15523 27 GVHD GVHD NNP cord-005453-4057qib7 15523 28 prophylaxis prophylaxis NN cord-005453-4057qib7 15523 29 is be VBZ cord-005453-4057qib7 15523 30 feasible feasible JJ cord-005453-4057qib7 15523 31 approach approach NN cord-005453-4057qib7 15523 32 with with IN cord-005453-4057qib7 15523 33 a a DT cord-005453-4057qib7 15523 34 low low JJ cord-005453-4057qib7 15523 35 TRM TRM NNP cord-005453-4057qib7 15523 36 . . . cord-005453-4057qib7 15524 1 The the DT cord-005453-4057qib7 15524 2 Background Background NNP cord-005453-4057qib7 15524 3 : : : cord-005453-4057qib7 15524 4 Anti Anti NNP cord-005453-4057qib7 15524 5 - - JJ cord-005453-4057qib7 15524 6 HLA HLA NNP cord-005453-4057qib7 15524 7 antibodies antibody NNS cord-005453-4057qib7 15524 8 ( ( -LRB- cord-005453-4057qib7 15524 9 aHAb ahab XX cord-005453-4057qib7 15524 10 ) ) -RRB- cord-005453-4057qib7 15524 11 have have VBP cord-005453-4057qib7 15524 12 been be VBN cord-005453-4057qib7 15524 13 recently recently RB cord-005453-4057qib7 15524 14 recognized recognize VBN cord-005453-4057qib7 15524 15 as as IN cord-005453-4057qib7 15524 16 an an DT cord-005453-4057qib7 15524 17 important important JJ cord-005453-4057qib7 15524 18 risk risk NN cord-005453-4057qib7 15524 19 factor factor NN cord-005453-4057qib7 15524 20 for for IN cord-005453-4057qib7 15524 21 graft graft NN cord-005453-4057qib7 15524 22 failure failure NN cord-005453-4057qib7 15524 23 ( ( -LRB- cord-005453-4057qib7 15524 24 GF GF NNP cord-005453-4057qib7 15524 25 ) ) -RRB- cord-005453-4057qib7 15524 26 , , , cord-005453-4057qib7 15524 27 especially especially RB cord-005453-4057qib7 15524 28 in in IN cord-005453-4057qib7 15524 29 HLA HLA NNP cord-005453-4057qib7 15524 30 - - HYPH cord-005453-4057qib7 15524 31 haploidentical haploidentical JJ cord-005453-4057qib7 15524 32 stem stem NN cord-005453-4057qib7 15524 33 cell cell NN cord-005453-4057qib7 15524 34 transplantation transplantation NN cord-005453-4057qib7 15524 35 ( ( -LRB- cord-005453-4057qib7 15524 36 haplo haplo NNP cord-005453-4057qib7 15524 37 - - HYPH cord-005453-4057qib7 15524 38 HSCT HSCT NNP cord-005453-4057qib7 15524 39 ) ) -RRB- cord-005453-4057qib7 15524 40 . . . cord-005453-4057qib7 15525 1 Although although IN cord-005453-4057qib7 15525 2 , , , cord-005453-4057qib7 15525 3 recently recently RB cord-005453-4057qib7 15525 4 , , , cord-005453-4057qib7 15525 5 EBMT EBMT NNP cord-005453-4057qib7 15525 6 consensus consensus NN cord-005453-4057qib7 15525 7 guidelines guideline NNS cord-005453-4057qib7 15525 8 have have VBP cord-005453-4057qib7 15525 9 been be VBN cord-005453-4057qib7 15525 10 published publish VBN cord-005453-4057qib7 15525 11 [ [ -LRB- cord-005453-4057qib7 15525 12 Ciurea Ciurea NNP cord-005453-4057qib7 15525 13 , , , cord-005453-4057qib7 15525 14 Bone Bone NNP cord-005453-4057qib7 15525 15 Marrow Marrow NNP cord-005453-4057qib7 15525 16 Transplant Transplant NNP cord-005453-4057qib7 15525 17 2018 2018 CD cord-005453-4057qib7 15525 18 ] ] -RRB- cord-005453-4057qib7 15525 19 , , , cord-005453-4057qib7 15525 20 experience experience NN cord-005453-4057qib7 15525 21 in in IN cord-005453-4057qib7 15525 22 pediatric pediatric JJ cord-005453-4057qib7 15525 23 T t NN cord-005453-4057qib7 15525 24 - - HYPH cord-005453-4057qib7 15525 25 cell cell NN cord-005453-4057qib7 15525 26 depleted deplete VBN cord-005453-4057qib7 15525 27 ( ( -LRB- cord-005453-4057qib7 15525 28 TCD TCD NNP cord-005453-4057qib7 15525 29 , , , cord-005453-4057qib7 15525 30 another another DT cord-005453-4057qib7 15525 31 well well RB cord-005453-4057qib7 15525 32 - - HYPH cord-005453-4057qib7 15525 33 known know VBN cord-005453-4057qib7 15525 34 risk risk NN cord-005453-4057qib7 15525 35 factor factor NN cord-005453-4057qib7 15525 36 for for IN cord-005453-4057qib7 15525 37 GF GF NNP cord-005453-4057qib7 15525 38 ) ) -RRB- cord-005453-4057qib7 15526 1 haplo haplo NNP cord-005453-4057qib7 15526 2 - - HYPH cord-005453-4057qib7 15526 3 HSCT HSCT NNP cord-005453-4057qib7 15526 4 is be VBZ cord-005453-4057qib7 15526 5 lacking lack VBG cord-005453-4057qib7 15526 6 . . . cord-005453-4057qib7 15527 1 In in IN cord-005453-4057qib7 15527 2 the the DT cord-005453-4057qib7 15527 3 present present JJ cord-005453-4057qib7 15527 4 study study NN cord-005453-4057qib7 15527 5 , , , cord-005453-4057qib7 15527 6 we -PRON- PRP cord-005453-4057qib7 15527 7 report report VBP cord-005453-4057qib7 15527 8 our -PRON- PRP$ cord-005453-4057qib7 15527 9 experience experience NN cord-005453-4057qib7 15527 10 on on IN cord-005453-4057qib7 15527 11 the the DT cord-005453-4057qib7 15527 12 use use NN cord-005453-4057qib7 15527 13 of of IN cord-005453-4057qib7 15527 14 a a DT cord-005453-4057qib7 15527 15 desensitization desensitization NN cord-005453-4057qib7 15527 16 approach approach NN cord-005453-4057qib7 15527 17 based base VBN cord-005453-4057qib7 15527 18 on on IN cord-005453-4057qib7 15527 19 EBMT EBMT NNP cord-005453-4057qib7 15527 20 guidelines guideline NNS cord-005453-4057qib7 15527 21 . . . cord-005453-4057qib7 15528 1 Methods method NNS cord-005453-4057qib7 15528 2 : : : cord-005453-4057qib7 15528 3 Between between IN cord-005453-4057qib7 15528 4 June June NNP cord-005453-4057qib7 15528 5 2017 2017 CD cord-005453-4057qib7 15528 6 and and CC cord-005453-4057qib7 15528 7 August August NNP cord-005453-4057qib7 15528 8 2018 2018 CD cord-005453-4057qib7 15528 9 , , , cord-005453-4057qib7 15528 10 all all DT cord-005453-4057qib7 15528 11 patients patient NNS cord-005453-4057qib7 15528 12 affected affect VBN cord-005453-4057qib7 15528 13 by by IN cord-005453-4057qib7 15528 14 non non JJ cord-005453-4057qib7 15528 15 - - JJ cord-005453-4057qib7 15528 16 malignant malignant JJ cord-005453-4057qib7 15528 17 diseases disease NNS cord-005453-4057qib7 15528 18 and and CC cord-005453-4057qib7 15528 19 scheduled schedule VBN cord-005453-4057qib7 15528 20 for for IN cord-005453-4057qib7 15528 21 a a DT cord-005453-4057qib7 15528 22 transplant transplant NN cord-005453-4057qib7 15528 23 from from IN cord-005453-4057qib7 15528 24 an an DT cord-005453-4057qib7 15528 25 HLA HLA NNP cord-005453-4057qib7 15528 26 - - HYPH cord-005453-4057qib7 15528 27 haploidentical haploidentical JJ cord-005453-4057qib7 15528 28 donor donor NN cord-005453-4057qib7 15528 29 after after IN cord-005453-4057qib7 15528 30 negative negative JJ cord-005453-4057qib7 15528 31 depletion depletion NN cord-005453-4057qib7 15528 32 of of IN cord-005453-4057qib7 15528 33 αβ αβ FW cord-005453-4057qib7 15528 34 T t NN cord-005453-4057qib7 15528 35 and and CC cord-005453-4057qib7 15528 36 B B NNP cord-005453-4057qib7 15528 37 cells cell NNS cord-005453-4057qib7 15528 38 as as IN cord-005453-4057qib7 15528 39 previously previously RB cord-005453-4057qib7 15528 40 described describe VBN cord-005453-4057qib7 15528 41 [ [ -LRB- cord-005453-4057qib7 15528 42 Li Li NNP cord-005453-4057qib7 15528 43 Pira Pira NNP cord-005453-4057qib7 15528 44 , , , cord-005453-4057qib7 15528 45 Biol Biol NNP cord-005453-4057qib7 15528 46 Blood Blood NNP cord-005453-4057qib7 15528 47 Marrow Marrow NNP cord-005453-4057qib7 15528 48 Transplant Transplant NNP cord-005453-4057qib7 15528 49 . . . cord-005453-4057qib7 15528 50 2016 2016 CD cord-005453-4057qib7 15528 51 ] ] -RRB- cord-005453-4057qib7 15528 52 , , , cord-005453-4057qib7 15528 53 were be VBD cord-005453-4057qib7 15528 54 tested test VBN cord-005453-4057qib7 15528 55 for for IN cord-005453-4057qib7 15528 56 aHAb ahab XX cord-005453-4057qib7 15528 57 with with IN cord-005453-4057qib7 15528 58 Luminex Luminex NNP cord-005453-4057qib7 15528 59 ® ® POS cord-005453-4057qib7 15528 60 solid solid JJ cord-005453-4057qib7 15528 61 - - HYPH cord-005453-4057qib7 15528 62 phase phase NN cord-005453-4057qib7 15528 63 immunoassay immunoassay NN cord-005453-4057qib7 15528 64 ( ( -LRB- cord-005453-4057qib7 15528 65 One one CD cord-005453-4057qib7 15528 66 Lambda Lambda NNP cord-005453-4057qib7 15528 67 , , , cord-005453-4057qib7 15528 68 Thermo Thermo NNP cord-005453-4057qib7 15528 69 Fisher Fisher NNP cord-005453-4057qib7 15528 70 Scientific Scientific NNP cord-005453-4057qib7 15528 71 ) ) -RRB- cord-005453-4057qib7 15528 72 1 1 CD cord-005453-4057qib7 15528 73 month month NN cord-005453-4057qib7 15528 74 before before IN cord-005453-4057qib7 15528 75 the the DT cord-005453-4057qib7 15528 76 HSCT HSCT NNP cord-005453-4057qib7 15528 77 . . . cord-005453-4057qib7 15529 1 All all DT cord-005453-4057qib7 15529 2 patients patient NNS cord-005453-4057qib7 15529 3 with with IN cord-005453-4057qib7 15529 4 a a DT cord-005453-4057qib7 15529 5 MFI MFI NNP cord-005453-4057qib7 15529 6 higher high JJR cord-005453-4057qib7 15529 7 than than IN cord-005453-4057qib7 15529 8 5000 5000 CD cord-005453-4057qib7 15529 9 , , , cord-005453-4057qib7 15529 10 which which WDT cord-005453-4057qib7 15529 11 is be VBZ cord-005453-4057qib7 15529 12 considered consider VBN cord-005453-4057qib7 15529 13 a a DT cord-005453-4057qib7 15529 14 cutoff cutoff NN cord-005453-4057qib7 15529 15 predicting predict VBG cord-005453-4057qib7 15529 16 for for IN cord-005453-4057qib7 15529 17 GF GF NNP cord-005453-4057qib7 15529 18 , , , cord-005453-4057qib7 15529 19 were be VBD cord-005453-4057qib7 15529 20 treated treat VBN cord-005453-4057qib7 15529 21 with with IN cord-005453-4057qib7 15529 22 a a DT cord-005453-4057qib7 15529 23 desensitization desensitization NN cord-005453-4057qib7 15529 24 protocol protocol NN cord-005453-4057qib7 15529 25 based base VBN cord-005453-4057qib7 15529 26 on on IN cord-005453-4057qib7 15529 27 the the DT cord-005453-4057qib7 15529 28 use use NN cord-005453-4057qib7 15529 29 of of IN cord-005453-4057qib7 15529 30 anti anti JJ cord-005453-4057qib7 15529 31 - - JJ cord-005453-4057qib7 15529 32 CD20 cd20 JJ cord-005453-4057qib7 15529 33 rituximab rituximab NN cord-005453-4057qib7 15529 34 ( ( -LRB- cord-005453-4057qib7 15529 35 375 375 CD cord-005453-4057qib7 15529 36 mg mg NNP cord-005453-4057qib7 15529 37 / / SYM cord-005453-4057qib7 15529 38 m m NNP cord-005453-4057qib7 15529 39 2 2 CD cord-005453-4057qib7 15529 40 before before RB cord-005453-4057qib7 15529 41 and and CC cord-005453-4057qib7 15529 42 immediately immediately RB cord-005453-4057qib7 15529 43 after after IN cord-005453-4057qib7 15529 44 the the DT cord-005453-4057qib7 15529 45 end end NN cord-005453-4057qib7 15529 46 of of IN cord-005453-4057qib7 15529 47 plasma plasma NN cord-005453-4057qib7 15529 48 - - HYPH cord-005453-4057qib7 15529 49 exchange exchange NN cord-005453-4057qib7 15529 50 cycle cycle NN cord-005453-4057qib7 15529 51 ) ) -RRB- cord-005453-4057qib7 15529 52 and and CC cord-005453-4057qib7 15530 1 plasma plasma NN cord-005453-4057qib7 15530 2 - - HYPH cord-005453-4057qib7 15530 3 exchange exchange NN cord-005453-4057qib7 15530 4 ( ( -LRB- cord-005453-4057qib7 15530 5 PE PE NNP cord-005453-4057qib7 15530 6 ) ) -RRB- cord-005453-4057qib7 15530 7 ± ± CC cord-005453-4057qib7 15530 8 infusion infusion NN cord-005453-4057qib7 15530 9 of of IN cord-005453-4057qib7 15530 10 irradiated irradiate VBN cord-005453-4057qib7 15530 11 buffy buffy NNP cord-005453-4057qib7 15530 12 coat coat NNP cord-005453-4057qib7 15530 13 ( ( -LRB- cord-005453-4057qib7 15530 14 BC BC NNP cord-005453-4057qib7 15530 15 ) ) -RRB- cord-005453-4057qib7 15530 16 ( ( -LRB- cord-005453-4057qib7 15530 17 if if IN cord-005453-4057qib7 15530 18 after after IN cord-005453-4057qib7 15530 19 PE PE NNP cord-005453-4057qib7 15530 20 aHAb ahab CD cord-005453-4057qib7 15530 21 MFI MFI NNP cord-005453-4057qib7 15530 22 was be VBD cord-005453-4057qib7 15530 23 still still RB cord-005453-4057qib7 15530 24 > > XX cord-005453-4057qib7 15530 25 5000 5000 CD cord-005453-4057qib7 15530 26 MFI MFI NNP cord-005453-4057qib7 15530 27 ) ) -RRB- cord-005453-4057qib7 15530 28 . . . cord-005453-4057qib7 15531 1 This this DT cord-005453-4057qib7 15531 2 latter latter NN cord-005453-4057qib7 15531 3 was be VBD cord-005453-4057qib7 15531 4 obtained obtain VBN cord-005453-4057qib7 15531 5 by by IN cord-005453-4057qib7 15531 6 the the DT cord-005453-4057qib7 15531 7 non non JJ cord-005453-4057qib7 15531 8 - - JJ cord-005453-4057qib7 15531 9 target target JJ cord-005453-4057qib7 15531 10 fraction fraction NN cord-005453-4057qib7 15531 11 of of IN cord-005453-4057qib7 15531 12 the the DT cord-005453-4057qib7 15531 13 αβ αβ XX cord-005453-4057qib7 15531 14 T t NN cord-005453-4057qib7 15531 15 - - HYPH cord-005453-4057qib7 15531 16 cell cell NN cord-005453-4057qib7 15531 17 / / SYM cord-005453-4057qib7 15531 18 B b NN cord-005453-4057qib7 15531 19 - - HYPH cord-005453-4057qib7 15531 20 cell cell NN cord-005453-4057qib7 15531 21 - - HYPH cord-005453-4057qib7 15531 22 depletion depletion NN cord-005453-4057qib7 15531 23 procedure procedure NN cord-005453-4057qib7 15531 24 and and CC cord-005453-4057qib7 15531 25 consisted consist VBD cord-005453-4057qib7 15531 26 of of IN cord-005453-4057qib7 15531 27 5 5 CD cord-005453-4057qib7 15531 28 * * SYM cord-005453-4057qib7 15531 29 10 10 CD cord-005453-4057qib7 15531 30 7 7 CD cord-005453-4057qib7 15531 31 irradiated irradiate VBN cord-005453-4057qib7 15531 32 nucleated nucleated JJ cord-005453-4057qib7 15531 33 cells cell NNS cord-005453-4057qib7 15531 34 / / SYM cord-005453-4057qib7 15531 35 kg kg NNS cord-005453-4057qib7 15531 36 of of IN cord-005453-4057qib7 15531 37 the the DT cord-005453-4057qib7 15531 38 recipient recipient NN cord-005453-4057qib7 15531 39 ; ; : cord-005453-4057qib7 15531 40 this this DT cord-005453-4057qib7 15531 41 was be VBD cord-005453-4057qib7 15531 42 infused infuse VBN cord-005453-4057qib7 15531 43 2 2 CD cord-005453-4057qib7 15531 44 - - SYM cord-005453-4057qib7 15531 45 4 4 CD cord-005453-4057qib7 15531 46 hours hour NNS cord-005453-4057qib7 15531 47 before before IN cord-005453-4057qib7 15531 48 the the DT cord-005453-4057qib7 15531 49 infusion infusion NN cord-005453-4057qib7 15531 50 of of IN cord-005453-4057qib7 15531 51 the the DT cord-005453-4057qib7 15531 52 TCD TCD NNP cord-005453-4057qib7 15531 53 graft graft NN cord-005453-4057qib7 15531 54 . . . cord-005453-4057qib7 15532 1 PE PE NNP cord-005453-4057qib7 15532 2 was be VBD cord-005453-4057qib7 15532 3 performed perform VBN cord-005453-4057qib7 15532 4 with with IN cord-005453-4057qib7 15532 5 Miltenyi Miltenyi NNP cord-005453-4057qib7 15532 6 Life Life NNP cord-005453-4057qib7 15532 7 18 18 CD cord-005453-4057qib7 15532 8 TM TM NNP cord-005453-4057qib7 15532 9 Apheresis Apheresis NNP cord-005453-4057qib7 15532 10 Unit Unit NNP cord-005453-4057qib7 15532 11 ( ( -LRB- cord-005453-4057qib7 15532 12 Miltenyi Miltenyi NNP cord-005453-4057qib7 15532 13 , , , cord-005453-4057qib7 15532 14 Bergish Bergish NNP cord-005453-4057qib7 15532 15 - - HYPH cord-005453-4057qib7 15532 16 Gladback Gladback NNP cord-005453-4057qib7 15533 1 ) ) -RRB- cord-005453-4057qib7 15533 2 .Results .Results NFP cord-005453-4057qib7 15533 3 : : : cord-005453-4057qib7 15534 1 In in IN cord-005453-4057qib7 15534 2 the the DT cord-005453-4057qib7 15534 3 study study NN cord-005453-4057qib7 15534 4 period period NN cord-005453-4057qib7 15534 5 , , , cord-005453-4057qib7 15534 6 37 37 CD cord-005453-4057qib7 15534 7 patients patient NNS cord-005453-4057qib7 15534 8 received receive VBD cord-005453-4057qib7 15534 9 αβ αβ FW cord-005453-4057qib7 15534 10 Tand Tand NNP cord-005453-4057qib7 15534 11 B b NN cord-005453-4057qib7 15534 12 - - HYPH cord-005453-4057qib7 15534 13 cell cell NN cord-005453-4057qib7 15534 14 depleted deplete VBN cord-005453-4057qib7 15534 15 haplo haplo NNP cord-005453-4057qib7 15534 16 - - HYPH cord-005453-4057qib7 15534 17 HSCT HSCT NNP cord-005453-4057qib7 15534 18 . . . cord-005453-4057qib7 15535 1 Eighteen eighteen CD cord-005453-4057qib7 15535 2 ( ( -LRB- cord-005453-4057qib7 15535 3 48 48 CD cord-005453-4057qib7 15535 4 % % NN cord-005453-4057qib7 15535 5 ) ) -RRB- cord-005453-4057qib7 15535 6 resulted result VBD cord-005453-4057qib7 15535 7 positive positive JJ cord-005453-4057qib7 15535 8 for for IN cord-005453-4057qib7 15535 9 aHAb ahab XX cord-005453-4057qib7 15535 10 ( ( -LRB- cord-005453-4057qib7 15535 11 MFI MFI NNP cord-005453-4057qib7 15535 12 > > XX cord-005453-4057qib7 15535 13 1000 1000 CD cord-005453-4057qib7 15535 14 ) ) -RRB- cord-005453-4057qib7 15535 15 ; ; : cord-005453-4057qib7 15535 16 14 14 CD cord-005453-4057qib7 15535 17 ( ( -LRB- cord-005453-4057qib7 15535 18 77 77 CD cord-005453-4057qib7 15535 19 % % NN cord-005453-4057qib7 15535 20 ) ) -RRB- cord-005453-4057qib7 15535 21 of of IN cord-005453-4057qib7 15535 22 them -PRON- PRP cord-005453-4057qib7 15535 23 had have VBD cord-005453-4057qib7 15535 24 an an DT cord-005453-4057qib7 15535 25 MFI mfi NN cord-005453-4057qib7 15535 26 > > XX cord-005453-4057qib7 15536 1 5000 5000 CD cord-005453-4057qib7 15536 2 for for IN cord-005453-4057qib7 15536 3 either either DT cord-005453-4057qib7 15536 4 anti anti JJ cord-005453-4057qib7 15536 5 - - JJ cord-005453-4057qib7 15536 6 class class JJ cord-005453-4057qib7 15536 7 I i NN cord-005453-4057qib7 15536 8 or or CC cord-005453-4057qib7 15536 9 II II NNP cord-005453-4057qib7 15536 10 aHAb ahab XX cord-005453-4057qib7 15536 11 . . . cord-005453-4057qib7 15537 1 These these DT cord-005453-4057qib7 15537 2 patients patient NNS cord-005453-4057qib7 15537 3 ( ( -LRB- cord-005453-4057qib7 15537 4 see see VB cord-005453-4057qib7 15537 5 Table table NN cord-005453-4057qib7 15538 1 I -PRON- PRP cord-005453-4057qib7 15538 2 Background Background NNP cord-005453-4057qib7 15538 3 : : : cord-005453-4057qib7 15539 1 Osteonecrosis Osteonecrosis NNP cord-005453-4057qib7 15539 2 ( ( -LRB- cord-005453-4057qib7 15539 3 ON ON NNP cord-005453-4057qib7 15539 4 ) ) -RRB- cord-005453-4057qib7 15539 5 is be VBZ cord-005453-4057qib7 15539 6 a a DT cord-005453-4057qib7 15539 7 debilitating debilitating JJ cord-005453-4057qib7 15539 8 complication complication NN cord-005453-4057qib7 15539 9 in in IN cord-005453-4057qib7 15539 10 survivors survivor NNS cord-005453-4057qib7 15539 11 of of IN cord-005453-4057qib7 15539 12 allogeneic allogeneic JJ cord-005453-4057qib7 15539 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 15539 14 cell cell NN cord-005453-4057qib7 15539 15 transplantation transplantation NN cord-005453-4057qib7 15539 16 ( ( -LRB- cord-005453-4057qib7 15539 17 HCT HCT NNP cord-005453-4057qib7 15539 18 ) ) -RRB- cord-005453-4057qib7 15539 19 . . . cord-005453-4057qib7 15540 1 Limited limited JJ cord-005453-4057qib7 15540 2 data datum NNS cord-005453-4057qib7 15540 3 is be VBZ cord-005453-4057qib7 15540 4 available available JJ cord-005453-4057qib7 15540 5 on on IN cord-005453-4057qib7 15540 6 its -PRON- PRP$ cord-005453-4057qib7 15540 7 course course NN cord-005453-4057qib7 15540 8 post post NN cord-005453-4057qib7 15540 9 - - NN cord-005453-4057qib7 15540 10 transplantation transplantation NN cord-005453-4057qib7 15540 11 in in IN cord-005453-4057qib7 15540 12 children child NNS cord-005453-4057qib7 15540 13 . . . cord-005453-4057qib7 15541 1 The the DT cord-005453-4057qib7 15541 2 purpose purpose NN cord-005453-4057qib7 15541 3 of of IN cord-005453-4057qib7 15541 4 our -PRON- PRP$ cord-005453-4057qib7 15541 5 study study NN cord-005453-4057qib7 15541 6 was be VBD cord-005453-4057qib7 15541 7 to to TO cord-005453-4057qib7 15541 8 identify identify VB cord-005453-4057qib7 15541 9 recipients recipient NNS cord-005453-4057qib7 15541 10 of of IN cord-005453-4057qib7 15541 11 HCT HCT NNP cord-005453-4057qib7 15541 12 in in IN cord-005453-4057qib7 15541 13 whom whom WP cord-005453-4057qib7 15541 14 pre pre VB cord-005453-4057qib7 15541 15 - - JJ cord-005453-4057qib7 15541 16 and and CC cord-005453-4057qib7 15541 17 post post JJ cord-005453-4057qib7 15541 18 - - JJ cord-005453-4057qib7 15541 19 magnetic magnetic JJ cord-005453-4057qib7 15541 20 resonance resonance NN cord-005453-4057qib7 15541 21 imaging imaging NN cord-005453-4057qib7 15541 22 ( ( -LRB- cord-005453-4057qib7 15541 23 MRI MRI NNP cord-005453-4057qib7 15541 24 ) ) -RRB- cord-005453-4057qib7 15541 25 is be VBZ cord-005453-4057qib7 15541 26 indicated indicate VBN cord-005453-4057qib7 15541 27 . . . cord-005453-4057qib7 15542 1 Methods method NNS cord-005453-4057qib7 15542 2 : : : cord-005453-4057qib7 15543 1 The the DT cord-005453-4057qib7 15543 2 retrospective retrospective JJ cord-005453-4057qib7 15543 3 cohort cohort NN cord-005453-4057qib7 15543 4 consisted consist VBD cord-005453-4057qib7 15543 5 of of IN cord-005453-4057qib7 15543 6 436 436 CD cord-005453-4057qib7 15543 7 patients patient NNS cord-005453-4057qib7 15543 8 who who WP cord-005453-4057qib7 15543 9 underwent undergo VBD cord-005453-4057qib7 15543 10 first first RB cord-005453-4057qib7 15543 11 allogeneic allogeneic NN cord-005453-4057qib7 15543 12 HCT hct NN cord-005453-4057qib7 15543 13 from from IN cord-005453-4057qib7 15543 14 1998 1998 CD cord-005453-4057qib7 15543 15 - - SYM cord-005453-4057qib7 15543 16 2014 2014 CD cord-005453-4057qib7 15543 17 , , , cord-005453-4057qib7 15543 18 and and CC cord-005453-4057qib7 15543 19 prospectively prospectively RB cord-005453-4057qib7 15543 20 underwent undergo VBD cord-005453-4057qib7 15543 21 a a DT cord-005453-4057qib7 15543 22 total total NN cord-005453-4057qib7 15543 23 of of IN cord-005453-4057qib7 15543 24 1092 1092 CD cord-005453-4057qib7 15543 25 pre pre JJ cord-005453-4057qib7 15543 26 - - JJ cord-005453-4057qib7 15543 27 and and CC cord-005453-4057qib7 15543 28 post post JJ cord-005453-4057qib7 15543 29 - - JJ cord-005453-4057qib7 15543 30 transplant transplant NN cord-005453-4057qib7 15543 31 MRI MRI NNP cord-005453-4057qib7 15543 32 studies study NNS cord-005453-4057qib7 15543 33 of of IN cord-005453-4057qib7 15543 34 the the DT cord-005453-4057qib7 15543 35 hips hip NNS cord-005453-4057qib7 15543 36 and and CC cord-005453-4057qib7 15543 37 knees knee NNS cord-005453-4057qib7 15543 38 done do VBN cord-005453-4057qib7 15543 39 annually annually RB cord-005453-4057qib7 15543 40 for for IN cord-005453-4057qib7 15543 41 3 3 CD cord-005453-4057qib7 15543 42 years year NNS cord-005453-4057qib7 15543 43 regardless regardless RB cord-005453-4057qib7 15543 44 of of IN cord-005453-4057qib7 15543 45 symptoms symptom NNS cord-005453-4057qib7 15543 46 . . . cord-005453-4057qib7 15544 1 Surviving survive VBG cord-005453-4057qib7 15544 2 patients patient NNS cord-005453-4057qib7 15544 3 were be VBD cord-005453-4057qib7 15544 4 followed follow VBN cord-005453-4057qib7 15544 5 for for IN cord-005453-4057qib7 15544 6 a a DT cord-005453-4057qib7 15544 7 median median JJ cord-005453-4057qib7 15544 8 time time NN cord-005453-4057qib7 15544 9 of of IN cord-005453-4057qib7 15544 10 8.33 8.33 CD cord-005453-4057qib7 15544 11 ( ( -LRB- cord-005453-4057qib7 15544 12 range range NNP cord-005453-4057qib7 15544 13 3.93 3.93 CD cord-005453-4057qib7 15544 14 - - SYM cord-005453-4057qib7 15544 15 14.10 14.10 CD cord-005453-4057qib7 15544 16 ) ) -RRB- cord-005453-4057qib7 15544 17 years year NNS cord-005453-4057qib7 15544 18 . . . cord-005453-4057qib7 15545 1 Cases case NNS cord-005453-4057qib7 15545 2 of of IN cord-005453-4057qib7 15545 3 ON ON NNP cord-005453-4057qib7 15545 4 were be VBD cord-005453-4057qib7 15545 5 compared compare VBN cord-005453-4057qib7 15545 6 to to IN cord-005453-4057qib7 15545 7 controls control NNS cord-005453-4057qib7 15545 8 matched match VBN cord-005453-4057qib7 15545 9 for for IN cord-005453-4057qib7 15545 10 age age NN cord-005453-4057qib7 15545 11 , , , cord-005453-4057qib7 15545 12 sex sex NN cord-005453-4057qib7 15545 13 , , , cord-005453-4057qib7 15545 14 transplant transplant NN cord-005453-4057qib7 15545 15 type type NN cord-005453-4057qib7 15545 16 , , , cord-005453-4057qib7 15545 17 and and CC cord-005453-4057qib7 15545 18 follow follow VB cord-005453-4057qib7 15545 19 up up RP cord-005453-4057qib7 15545 20 in in IN cord-005453-4057qib7 15545 21 a a DT cord-005453-4057qib7 15545 22 1:4 1:4 CD cord-005453-4057qib7 15545 23 ratio ratio NN cord-005453-4057qib7 15545 24 for for IN cord-005453-4057qib7 15545 25 the the DT cord-005453-4057qib7 15545 26 following follow VBG cord-005453-4057qib7 15545 27 variables variable NNS cord-005453-4057qib7 15545 28 : : : cord-005453-4057qib7 15545 29 ethnicity ethnicity NN cord-005453-4057qib7 15545 30 , , , cord-005453-4057qib7 15545 31 underlying underlie VBG cord-005453-4057qib7 15545 32 disease disease NN cord-005453-4057qib7 15545 33 , , . cord-005453-4057qib7 15546 1 ON on IN cord-005453-4057qib7 15546 2 pre pre JJ cord-005453-4057qib7 15546 3 - - JJ cord-005453-4057qib7 15546 4 HCT hct JJ cord-005453-4057qib7 15546 5 , , , cord-005453-4057qib7 15546 6 conditioning conditioning NN cord-005453-4057qib7 15546 7 regimen regimen NN cord-005453-4057qib7 15546 8 , , , cord-005453-4057qib7 15546 9 graft graft NN cord-005453-4057qib7 15546 10 source source NN cord-005453-4057qib7 15546 11 , , , cord-005453-4057qib7 15546 12 bone bone NN cord-005453-4057qib7 15546 13 mineral mineral NN cord-005453-4057qib7 15546 14 density density NN cord-005453-4057qib7 15546 15 Z Z NNP cord-005453-4057qib7 15546 16 - - HYPH cord-005453-4057qib7 15546 17 scores score NNS cord-005453-4057qib7 15546 18 , , , cord-005453-4057qib7 15546 19 body body NN cord-005453-4057qib7 15546 20 mass mass NN cord-005453-4057qib7 15546 21 index index NN cord-005453-4057qib7 15546 22 , , , cord-005453-4057qib7 15546 23 presence presence NN cord-005453-4057qib7 15546 24 or or CC cord-005453-4057qib7 15546 25 absence absence NN cord-005453-4057qib7 15546 26 of of IN cord-005453-4057qib7 15546 27 graft graft NN cord-005453-4057qib7 15546 28 - - HYPH cord-005453-4057qib7 15546 29 versus versus IN cord-005453-4057qib7 15546 30 - - HYPH cord-005453-4057qib7 15546 31 host host NN cord-005453-4057qib7 15546 32 disease disease NN cord-005453-4057qib7 15546 33 , , , cord-005453-4057qib7 15546 34 steroid steroid NN cord-005453-4057qib7 15546 35 use use NN cord-005453-4057qib7 15546 36 and and CC cord-005453-4057qib7 15546 37 dosage dosage NN cord-005453-4057qib7 15546 38 , , , cord-005453-4057qib7 15546 39 and and CC cord-005453-4057qib7 15546 40 survival survival NN cord-005453-4057qib7 15546 41 status status NN cord-005453-4057qib7 15546 42 . . . cord-005453-4057qib7 15547 1 Results result NNS cord-005453-4057qib7 15547 2 : : : cord-005453-4057qib7 15548 1 Thirty thirty CD cord-005453-4057qib7 15548 2 ( ( -LRB- cord-005453-4057qib7 15548 3 6.9 6.9 CD cord-005453-4057qib7 15548 4 % % NN cord-005453-4057qib7 15548 5 ) ) -RRB- cord-005453-4057qib7 15548 6 patients patient NNS cord-005453-4057qib7 15548 7 had have VBD cord-005453-4057qib7 15548 8 MRI MRI NNP cord-005453-4057qib7 15548 9 findings finding NNS cord-005453-4057qib7 15548 10 confirming confirm VBG cord-005453-4057qib7 15548 11 ON on IN cord-005453-4057qib7 15548 12 post post JJ cord-005453-4057qib7 15548 13 - - JJ cord-005453-4057qib7 15548 14 HCT hct NN cord-005453-4057qib7 15548 15 . . . cord-005453-4057qib7 15549 1 All all DT cord-005453-4057qib7 15549 2 patients patient NNS cord-005453-4057qib7 15549 3 with with IN cord-005453-4057qib7 15549 4 ON on IN cord-005453-4057qib7 15549 5 except except IN cord-005453-4057qib7 15549 6 one one CD cord-005453-4057qib7 15549 7 were be VBD cord-005453-4057qib7 15549 8 more more JJR cord-005453-4057qib7 15549 9 than than IN cord-005453-4057qib7 15549 10 10 10 CD cord-005453-4057qib7 15549 11 years year NNS cord-005453-4057qib7 15549 12 of of IN cord-005453-4057qib7 15549 13 age age NN cord-005453-4057qib7 15549 14 . . . cord-005453-4057qib7 15550 1 Twenty twenty CD cord-005453-4057qib7 15550 2 ( ( -LRB- cord-005453-4057qib7 15550 3 67 67 CD cord-005453-4057qib7 15550 4 % % NN cord-005453-4057qib7 15550 5 ) ) -RRB- cord-005453-4057qib7 15550 6 patients patient NNS cord-005453-4057qib7 15550 7 were be VBD cord-005453-4057qib7 15550 8 male male JJ cord-005453-4057qib7 15550 9 . . . cord-005453-4057qib7 15551 1 ON on IN cord-005453-4057qib7 15551 2 pre pre JJ cord-005453-4057qib7 15551 3 - - JJ cord-005453-4057qib7 15551 4 HCT hct JJ cord-005453-4057qib7 15551 5 ( ( -LRB- cord-005453-4057qib7 15551 6 P p NN cord-005453-4057qib7 15551 7 < < XX cord-005453-4057qib7 15551 8 0.0001 0.0001 CD cord-005453-4057qib7 15551 9 ) ) -RRB- cord-005453-4057qib7 15551 10 was be VBD cord-005453-4057qib7 15551 11 the the DT cord-005453-4057qib7 15551 12 only only JJ cord-005453-4057qib7 15551 13 factor factor NN cord-005453-4057qib7 15551 14 associated associate VBN cord-005453-4057qib7 15551 15 with with IN cord-005453-4057qib7 15551 16 presence presence NN cord-005453-4057qib7 15551 17 of of IN cord-005453-4057qib7 15551 18 ON on IN cord-005453-4057qib7 15551 19 post post JJ cord-005453-4057qib7 15551 20 - - JJ cord-005453-4057qib7 15551 21 HCT hct NN cord-005453-4057qib7 15551 22 . . . cord-005453-4057qib7 15552 1 Epiphyseal Epiphyseal NNP cord-005453-4057qib7 15552 2 ON ON NNP cord-005453-4057qib7 15552 3 was be VBD cord-005453-4057qib7 15552 4 seen see VBN cord-005453-4057qib7 15552 5 in in IN cord-005453-4057qib7 15552 6 9 9 CD cord-005453-4057qib7 15552 7 ( ( -LRB- cord-005453-4057qib7 15552 8 30 30 CD cord-005453-4057qib7 15552 9 % % NN cord-005453-4057qib7 15552 10 ) ) -RRB- cord-005453-4057qib7 15552 11 patients patient NNS cord-005453-4057qib7 15552 12 pre pre JJ cord-005453-4057qib7 15552 13 - - NN cord-005453-4057qib7 15552 14 HCT HCT NNP cord-005453-4057qib7 15552 15 , , , cord-005453-4057qib7 15552 16 and and CC cord-005453-4057qib7 15552 17 26 26 CD cord-005453-4057qib7 15552 18 ( ( -LRB- cord-005453-4057qib7 15552 19 87 87 CD cord-005453-4057qib7 15552 20 % % NN cord-005453-4057qib7 15552 21 ) ) -RRB- cord-005453-4057qib7 15552 22 post post JJ cord-005453-4057qib7 15552 23 - - JJ cord-005453-4057qib7 15552 24 HCT hct NN cord-005453-4057qib7 15552 25 . . . cord-005453-4057qib7 15553 1 Eighteen eighteen CD cord-005453-4057qib7 15553 2 ( ( -LRB- cord-005453-4057qib7 15553 3 60 60 CD cord-005453-4057qib7 15553 4 % % NN cord-005453-4057qib7 15553 5 ) ) -RRB- cord-005453-4057qib7 15553 6 patients patient NNS cord-005453-4057qib7 15553 7 had have VBD cord-005453-4057qib7 15553 8 involvement involvement NN cord-005453-4057qib7 15553 9 of of IN cord-005453-4057qib7 15553 10 more more JJR cord-005453-4057qib7 15553 11 than than IN cord-005453-4057qib7 15553 12 30 30 CD cord-005453-4057qib7 15553 13 % % NN cord-005453-4057qib7 15553 14 of of IN cord-005453-4057qib7 15553 15 articular articular JJ cord-005453-4057qib7 15553 16 surface surface NN cord-005453-4057qib7 15553 17 , , , cord-005453-4057qib7 15553 18 and and CC cord-005453-4057qib7 15553 19 were be VBD cord-005453-4057qib7 15553 20 more more RBR cord-005453-4057qib7 15553 21 likely likely JJ cord-005453-4057qib7 15553 22 to to TO cord-005453-4057qib7 15553 23 undergo undergo VB cord-005453-4057qib7 15553 24 surgery surgery NN cord-005453-4057qib7 15553 25 ( ( -LRB- cord-005453-4057qib7 15553 26 P p NN cord-005453-4057qib7 15553 27 = = SYM cord-005453-4057qib7 15553 28 0.009).Conclusions 0.009).conclusions CD cord-005453-4057qib7 15553 29 : : : cord-005453-4057qib7 15554 1 The the DT cord-005453-4057qib7 15554 2 incidence incidence NN cord-005453-4057qib7 15554 3 of of IN cord-005453-4057qib7 15554 4 ON on RB cord-005453-4057qib7 15554 5 in in IN cord-005453-4057qib7 15554 6 this this DT cord-005453-4057qib7 15554 7 large large JJ cord-005453-4057qib7 15554 8 pediatric pediatric JJ cord-005453-4057qib7 15554 9 cohort cohort NN cord-005453-4057qib7 15554 10 was be VBD cord-005453-4057qib7 15554 11 7 7 CD cord-005453-4057qib7 15554 12 % % NN cord-005453-4057qib7 15554 13 . . . cord-005453-4057qib7 15555 1 The the DT cord-005453-4057qib7 15555 2 only only JJ cord-005453-4057qib7 15555 3 risk risk NN cord-005453-4057qib7 15555 4 factor factor NN cord-005453-4057qib7 15555 5 for for IN cord-005453-4057qib7 15555 6 ON on IN cord-005453-4057qib7 15555 7 post post JJ cord-005453-4057qib7 15555 8 - - NN cord-005453-4057qib7 15555 9 HCT HCT NNP cord-005453-4057qib7 15555 10 was be VBD cord-005453-4057qib7 15555 11 pre pre JJ cord-005453-4057qib7 15555 12 - - JJ cord-005453-4057qib7 15555 13 existing existing JJ cord-005453-4057qib7 15555 14 ON on RP cord-005453-4057qib7 15555 15 . . . cord-005453-4057qib7 15556 1 MRI MRI NNP cord-005453-4057qib7 15556 2 evaluation evaluation NN cord-005453-4057qib7 15556 3 for for IN cord-005453-4057qib7 15556 4 ON on IN cord-005453-4057qib7 15556 5 pre pre JJ cord-005453-4057qib7 15556 6 - - JJ cord-005453-4057qib7 15556 7 HCT HCT NNP cord-005453-4057qib7 15556 8 is be VBZ cord-005453-4057qib7 15556 9 indicated indicate VBN cord-005453-4057qib7 15556 10 in in IN cord-005453-4057qib7 15556 11 all all DT cord-005453-4057qib7 15556 12 patients patient NNS cord-005453-4057qib7 15556 13 . . . cord-005453-4057qib7 15557 1 MRI MRI NNP cord-005453-4057qib7 15557 2 evaluation evaluation NN cord-005453-4057qib7 15557 3 for for IN cord-005453-4057qib7 15557 4 ON on IN cord-005453-4057qib7 15557 5 post post JJ cord-005453-4057qib7 15557 6 - - JJ cord-005453-4057qib7 15557 7 HCT HCT NNP cord-005453-4057qib7 15557 8 is be VBZ cord-005453-4057qib7 15557 9 only only RB cord-005453-4057qib7 15557 10 indicated indicate VBN cord-005453-4057qib7 15557 11 for for IN cord-005453-4057qib7 15557 12 patients patient NNS cord-005453-4057qib7 15557 13 with with IN cord-005453-4057qib7 15557 14 ON on IN cord-005453-4057qib7 15557 15 pre pre JJ cord-005453-4057qib7 15557 16 - - JJ cord-005453-4057qib7 15557 17 HCT hct JJ cord-005453-4057qib7 15557 18 and and CC cord-005453-4057qib7 15557 19 symptomatic symptomatic JJ cord-005453-4057qib7 15557 20 patients patient NNS cord-005453-4057qib7 15557 21 . . . cord-005453-4057qib7 15558 1 This this DT cord-005453-4057qib7 15558 2 will will MD cord-005453-4057qib7 15558 3 entail entail VB cord-005453-4057qib7 15558 4 cost cost NN cord-005453-4057qib7 15558 5 savings saving NNS cord-005453-4057qib7 15558 6 of of IN cord-005453-4057qib7 15558 7 USD usd NN cord-005453-4057qib7 15558 8 500,000 500,000 CD cord-005453-4057qib7 15558 9 per per IN cord-005453-4057qib7 15558 10 100 100 CD cord-005453-4057qib7 15558 11 surviving survive VBG cord-005453-4057qib7 15558 12 allogeneic allogeneic IN cord-005453-4057qib7 15558 13 HCT hct NN cord-005453-4057qib7 15558 14 patients patient NNS cord-005453-4057qib7 15558 15 per per IN cord-005453-4057qib7 15558 16 year year NN cord-005453-4057qib7 15558 17 . . . cord-005453-4057qib7 15559 1 Patients patient NNS cord-005453-4057qib7 15559 2 with with IN cord-005453-4057qib7 15559 3 more more JJR cord-005453-4057qib7 15559 4 than than IN cord-005453-4057qib7 15559 5 30 30 CD cord-005453-4057qib7 15559 6 % % NN cord-005453-4057qib7 15559 7 involvement involvement NN cord-005453-4057qib7 15559 8 of of IN cord-005453-4057qib7 15559 9 the the DT cord-005453-4057qib7 15559 10 articular articular JJ cord-005453-4057qib7 15559 11 surface surface NN cord-005453-4057qib7 15559 12 need nee MD cord-005453-4057qib7 15559 13 close close RB cord-005453-4057qib7 15559 14 follow follow NN cord-005453-4057qib7 15559 15 up up RP cord-005453-4057qib7 15559 16 . . . cord-005453-4057qib7 15560 1 Clinical clinical JJ cord-005453-4057qib7 15560 2 Trial Trial NNP cord-005453-4057qib7 15560 3 Registry Registry NNP cord-005453-4057qib7 15560 4 : : : cord-005453-4057qib7 15561 1 None none NN cord-005453-4057qib7 15561 2 Disclosure disclosure NN cord-005453-4057qib7 15561 3 : : : cord-005453-4057qib7 15561 4 None None NNP cord-005453-4057qib7 15561 5 Impact Impact NNP cord-005453-4057qib7 15561 6 of of IN cord-005453-4057qib7 15561 7 rabbit rabbit NN cord-005453-4057qib7 15561 8 anti anti NNP cord-005453-4057qib7 15561 9 thymocyte thymocyte NNP cord-005453-4057qib7 15561 10 globulin globulin NN cord-005453-4057qib7 15561 11 exposure exposure NN cord-005453-4057qib7 15561 12 on on IN cord-005453-4057qib7 15561 13 immune immune JJ cord-005453-4057qib7 15561 14 reconstitution reconstitution NN cord-005453-4057qib7 15561 15 and and CC cord-005453-4057qib7 15561 16 outcome outcome NN cord-005453-4057qib7 15561 17 after after IN cord-005453-4057qib7 15561 18 stem stem NN cord-005453-4057qib7 15561 19 cell cell NN cord-005453-4057qib7 15561 20 transplantation transplantation NN cord-005453-4057qib7 15561 21 in in IN cord-005453-4057qib7 15561 22 children child NNS cord-005453-4057qib7 15561 23 Background background NN cord-005453-4057qib7 15561 24 : : : cord-005453-4057qib7 15562 1 Rabbit Rabbit NNP cord-005453-4057qib7 15562 2 anti anti JJ cord-005453-4057qib7 15562 3 thymocyte thymocyte NN cord-005453-4057qib7 15562 4 globulin globulin NN cord-005453-4057qib7 15562 5 ( ( -LRB- cord-005453-4057qib7 15562 6 rATG rATG NNP cord-005453-4057qib7 15562 7 ) ) -RRB- cord-005453-4057qib7 15562 8 has have VBZ cord-005453-4057qib7 15562 9 been be VBN cord-005453-4057qib7 15562 10 frequently frequently RB cord-005453-4057qib7 15562 11 used use VBN cord-005453-4057qib7 15562 12 for for IN cord-005453-4057qib7 15562 13 many many JJ cord-005453-4057qib7 15562 14 years year NNS cord-005453-4057qib7 15562 15 as as IN cord-005453-4057qib7 15562 16 GvHD GvHD NNP cord-005453-4057qib7 15562 17 prophylaxis prophylaxis NN cord-005453-4057qib7 15562 18 in in IN cord-005453-4057qib7 15562 19 pediatric pediatric JJ cord-005453-4057qib7 15562 20 stem stem NN cord-005453-4057qib7 15562 21 cell cell NN cord-005453-4057qib7 15562 22 transplantation transplantation NN cord-005453-4057qib7 15562 23 . . . cord-005453-4057qib7 15563 1 Precise precise JJ cord-005453-4057qib7 15563 2 dosing dosing NN cord-005453-4057qib7 15563 3 regimens regimen NNS cord-005453-4057qib7 15563 4 are be VBP cord-005453-4057qib7 15563 5 crucial crucial JJ cord-005453-4057qib7 15563 6 but but CC cord-005453-4057qib7 15563 7 remain remain VBP cord-005453-4057qib7 15563 8 challenging challenging JJ cord-005453-4057qib7 15563 9 due due IN cord-005453-4057qib7 15563 10 to to IN cord-005453-4057qib7 15563 11 several several JJ cord-005453-4057qib7 15563 12 pharmacological pharmacological JJ cord-005453-4057qib7 15563 13 characteristics characteristic NNS cord-005453-4057qib7 15563 14 in in IN cord-005453-4057qib7 15563 15 children child NNS cord-005453-4057qib7 15563 16 . . . cord-005453-4057qib7 15564 1 Methods method NNS cord-005453-4057qib7 15564 2 : : : cord-005453-4057qib7 15565 1 rATG ratg JJ cord-005453-4057qib7 15565 2 levels level NNS cord-005453-4057qib7 15565 3 were be VBD cord-005453-4057qib7 15565 4 measured measure VBN cord-005453-4057qib7 15565 5 in in IN cord-005453-4057qib7 15565 6 pediatric pediatric JJ cord-005453-4057qib7 15565 7 patients patient NNS cord-005453-4057qib7 15565 8 undergoing undergo VBG cord-005453-4057qib7 15565 9 allogeneic allogeneic IN cord-005453-4057qib7 15565 10 stem stem NN cord-005453-4057qib7 15565 11 cell cell NN cord-005453-4057qib7 15565 12 transplantation transplantation NN cord-005453-4057qib7 15565 13 after after IN cord-005453-4057qib7 15565 14 obtaining obtain VBG cord-005453-4057qib7 15565 15 approval approval NN cord-005453-4057qib7 15565 16 by by IN cord-005453-4057qib7 15565 17 the the DT cord-005453-4057qib7 15565 18 local local JJ cord-005453-4057qib7 15565 19 IRB IRB NNP cord-005453-4057qib7 15565 20 and and CC cord-005453-4057qib7 15565 21 informed informed JJ cord-005453-4057qib7 15565 22 consent consent NN cord-005453-4057qib7 15565 23 by by IN cord-005453-4057qib7 15565 24 legal legal JJ cord-005453-4057qib7 15565 25 guardians guardian NNS cord-005453-4057qib7 15565 26 . . . cord-005453-4057qib7 15566 1 32 32 CD cord-005453-4057qib7 15566 2 pediatric pediatric JJ cord-005453-4057qib7 15566 3 patients patient NNS cord-005453-4057qib7 15566 4 who who WP cord-005453-4057qib7 15566 5 received receive VBD cord-005453-4057qib7 15566 6 either either CC cord-005453-4057qib7 15566 7 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 15566 8 ™ ™ , cord-005453-4057qib7 15566 9 ( ( -LRB- cord-005453-4057qib7 15566 10 n=22 n=22 NNP cord-005453-4057qib7 15566 11 ) ) -RRB- cord-005453-4057qib7 15566 12 or or CC cord-005453-4057qib7 15566 13 Grafalon Grafalon NNP cord-005453-4057qib7 15566 14 ™ ™ NN cord-005453-4057qib7 15566 15 ( ( -LRB- cord-005453-4057qib7 15566 16 ATG ATG NNP cord-005453-4057qib7 15566 17 - - HYPH cord-005453-4057qib7 15566 18 F F NNP cord-005453-4057qib7 15566 19 ) ) -RRB- cord-005453-4057qib7 15566 20 ( ( -LRB- cord-005453-4057qib7 15566 21 n=10 n=10 NNP cord-005453-4057qib7 15566 22 ) ) -RRB- cord-005453-4057qib7 15566 23 as as IN cord-005453-4057qib7 15566 24 part part NN cord-005453-4057qib7 15566 25 of of IN cord-005453-4057qib7 15566 26 their -PRON- PRP$ cord-005453-4057qib7 15566 27 conditioning conditioning NN cord-005453-4057qib7 15566 28 regimen regimen NN cord-005453-4057qib7 15567 1 Background background NN cord-005453-4057qib7 15567 2 : : : cord-005453-4057qib7 15567 3 Obesity obesity NN cord-005453-4057qib7 15567 4 among among IN cord-005453-4057qib7 15567 5 children child NNS cord-005453-4057qib7 15567 6 is be VBZ cord-005453-4057qib7 15567 7 a a DT cord-005453-4057qib7 15567 8 growing grow VBG cord-005453-4057qib7 15567 9 health health NN cord-005453-4057qib7 15567 10 problem problem NN cord-005453-4057qib7 15567 11 . . . cord-005453-4057qib7 15568 1 malnutrition malnutrition NN cord-005453-4057qib7 15568 2 or or CC cord-005453-4057qib7 15568 3 being be VBG cord-005453-4057qib7 15568 4 over over IN cord-005453-4057qib7 15568 5 - - HYPH cord-005453-4057qib7 15568 6 weight weight NN cord-005453-4057qib7 15568 7 can can MD cord-005453-4057qib7 15568 8 be be VB cord-005453-4057qib7 15568 9 of of IN cord-005453-4057qib7 15568 10 prognostic prognostic JJ cord-005453-4057qib7 15568 11 impact impact NN cord-005453-4057qib7 15568 12 among among IN cord-005453-4057qib7 15568 13 children child NNS cord-005453-4057qib7 15568 14 who who WP cord-005453-4057qib7 15568 15 need need VBP cord-005453-4057qib7 15568 16 HSCT.Scientific HSCT.Scientific NNP cord-005453-4057qib7 15568 17 literature literature NN cord-005453-4057qib7 15568 18 shows show VBZ cord-005453-4057qib7 15568 19 a a DT cord-005453-4057qib7 15568 20 lot lot NN cord-005453-4057qib7 15568 21 of of IN cord-005453-4057qib7 15568 22 controversy controversy NN cord-005453-4057qib7 15568 23 in in IN cord-005453-4057qib7 15568 24 terms term NNS cord-005453-4057qib7 15568 25 of of IN cord-005453-4057qib7 15568 26 effect effect NN cord-005453-4057qib7 15568 27 of of IN cord-005453-4057qib7 15568 28 BMI BMI NNP cord-005453-4057qib7 15568 29 at at IN cord-005453-4057qib7 15568 30 the the DT cord-005453-4057qib7 15568 31 time time NN cord-005453-4057qib7 15568 32 of of IN cord-005453-4057qib7 15568 33 infusion infusion NN cord-005453-4057qib7 15568 34 on on IN cord-005453-4057qib7 15568 35 the the DT cord-005453-4057qib7 15568 36 outcome outcome NN cord-005453-4057qib7 15568 37 of of IN cord-005453-4057qib7 15568 38 HSCT.Methods HSCT.Methods NNPS cord-005453-4057qib7 15569 1 : : : cord-005453-4057qib7 15569 2 We -PRON- PRP cord-005453-4057qib7 15569 3 reviewed review VBD cord-005453-4057qib7 15569 4 data datum NNS cord-005453-4057qib7 15569 5 of of IN cord-005453-4057qib7 15569 6 patients patient NNS cord-005453-4057qib7 15569 7 who who WP cord-005453-4057qib7 15569 8 underwent undergo VBD cord-005453-4057qib7 15569 9 HSCT HSCT NNP cord-005453-4057qib7 15569 10 at at IN cord-005453-4057qib7 15569 11 King King NNP cord-005453-4057qib7 15569 12 Faisal Faisal NNP cord-005453-4057qib7 15569 13 Specialist Specialist NNP cord-005453-4057qib7 15569 14 Hospital Hospital NNP cord-005453-4057qib7 15569 15 & & CC cord-005453-4057qib7 15569 16 Research Research NNP cord-005453-4057qib7 15569 17 Centre Centre NNP cord-005453-4057qib7 15569 18 between between IN cord-005453-4057qib7 15569 19 2010 2010 CD cord-005453-4057qib7 15569 20 - - SYM cord-005453-4057qib7 15569 21 2016 2016 CD cord-005453-4057qib7 15569 22 to to TO cord-005453-4057qib7 15569 23 correlate correlate VB cord-005453-4057qib7 15569 24 BMI BMI NNP cord-005453-4057qib7 15569 25 with with IN cord-005453-4057qib7 15569 26 the the DT cord-005453-4057qib7 15569 27 outcome outcome NN cord-005453-4057qib7 15569 28 and and CC cord-005453-4057qib7 15569 29 complications complication NNS cord-005453-4057qib7 15569 30 of of IN cord-005453-4057qib7 15569 31 HSCT HSCT NNP cord-005453-4057qib7 15569 32 . . . cord-005453-4057qib7 15570 1 Transplant transplant NN cord-005453-4057qib7 15570 2 naïve naïve JJ cord-005453-4057qib7 15570 3 recipients recipient NNS cord-005453-4057qib7 15570 4 with with IN cord-005453-4057qib7 15570 5 age age NN cord-005453-4057qib7 15570 6 at at IN cord-005453-4057qib7 15570 7 infusion infusion NN cord-005453-4057qib7 15570 8 between between IN cord-005453-4057qib7 15570 9 2 2 CD cord-005453-4057qib7 15570 10 - - SYM cord-005453-4057qib7 15570 11 14 14 CD cord-005453-4057qib7 15570 12 years year NNS cord-005453-4057qib7 15570 13 who who WP cord-005453-4057qib7 15570 14 received receive VBD cord-005453-4057qib7 15570 15 HSCT HSCT NNP cord-005453-4057qib7 15570 16 from from IN cord-005453-4057qib7 15570 17 matched matched JJ cord-005453-4057qib7 15570 18 related related JJ cord-005453-4057qib7 15570 19 donor donor NN cord-005453-4057qib7 15570 20 or or CC cord-005453-4057qib7 15570 21 autologous autologous JJ cord-005453-4057qib7 15570 22 HSCT HSCT NNP cord-005453-4057qib7 15570 23 , , , cord-005453-4057qib7 15570 24 were be VBD cord-005453-4057qib7 15570 25 included include VBN cord-005453-4057qib7 15570 26 in in IN cord-005453-4057qib7 15570 27 the the DT cord-005453-4057qib7 15570 28 dataset dataset NN cord-005453-4057qib7 15570 29 for for IN cord-005453-4057qib7 15570 30 analysis analysis NN cord-005453-4057qib7 15570 31 . . . cord-005453-4057qib7 15571 1 A a DT cord-005453-4057qib7 15571 2 total total NN cord-005453-4057qib7 15571 3 of of IN cord-005453-4057qib7 15571 4 423 423 CD cord-005453-4057qib7 15571 5 patients patient NNS cord-005453-4057qib7 15571 6 ' ' POS cord-005453-4057qib7 15571 7 profiles profile NNS cord-005453-4057qib7 15571 8 were be VBD cord-005453-4057qib7 15571 9 reviewed review VBN cord-005453-4057qib7 15571 10 of of IN cord-005453-4057qib7 15571 11 whom whom WP cord-005453-4057qib7 15571 12 51.1 51.1 CD cord-005453-4057qib7 15571 13 % % NN cord-005453-4057qib7 15571 14 were be VBD cord-005453-4057qib7 15571 15 boys boy NNS cord-005453-4057qib7 15571 16 . . . cord-005453-4057qib7 15572 1 Median median JJ cord-005453-4057qib7 15572 2 age age NN cord-005453-4057qib7 15572 3 at at IN cord-005453-4057qib7 15572 4 transplant transplant NN cord-005453-4057qib7 15572 5 was be VBD cord-005453-4057qib7 15572 6 7.5 7.5 CD cord-005453-4057qib7 15572 7 years year NNS cord-005453-4057qib7 15572 8 . . . cord-005453-4057qib7 15573 1 Primary primary JJ cord-005453-4057qib7 15573 2 indication indication NN cord-005453-4057qib7 15573 3 of of IN cord-005453-4057qib7 15573 4 disease disease NN cord-005453-4057qib7 15573 5 was be VBD cord-005453-4057qib7 15573 6 malignancy malignancy NN cord-005453-4057qib7 15573 7 in in IN cord-005453-4057qib7 15573 8 41.6 41.6 CD cord-005453-4057qib7 15573 9 % % NN cord-005453-4057qib7 15573 10 followed follow VBN cord-005453-4057qib7 15573 11 by by IN cord-005453-4057qib7 15573 12 hemoglobinopathies hemoglobinopathy NNS cord-005453-4057qib7 15573 13 26.7 26.7 CD cord-005453-4057qib7 15573 14 % % NN cord-005453-4057qib7 15573 15 , , , cord-005453-4057qib7 15573 16 bone bone NN cord-005453-4057qib7 15573 17 marrow marrow NN cord-005453-4057qib7 15573 18 failures failure NNS cord-005453-4057qib7 15573 19 17.3 17.3 CD cord-005453-4057qib7 15573 20 % % NN cord-005453-4057qib7 15573 21 and and CC cord-005453-4057qib7 15573 22 immune immune JJ cord-005453-4057qib7 15573 23 disorders disorder NNS cord-005453-4057qib7 15573 24 12.5 12.5 CD cord-005453-4057qib7 15573 25 % % NN cord-005453-4057qib7 15573 26 . . . cord-005453-4057qib7 15574 1 Solid solid JJ cord-005453-4057qib7 15574 2 tumors tumor NNS cord-005453-4057qib7 15574 3 accounted account VBD cord-005453-4057qib7 15574 4 for for IN cord-005453-4057qib7 15574 5 29.5 29.5 CD cord-005453-4057qib7 15574 6 % % NN cord-005453-4057qib7 15574 7 among among IN cord-005453-4057qib7 15574 8 malignant malignant JJ cord-005453-4057qib7 15574 9 disorders disorder NNS cord-005453-4057qib7 15574 10 . . . cord-005453-4057qib7 15575 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 15575 2 conditioning conditioning NN cord-005453-4057qib7 15575 3 was be VBD cord-005453-4057qib7 15575 4 used use VBN cord-005453-4057qib7 15575 5 in in IN cord-005453-4057qib7 15575 6 97.2 97.2 CD cord-005453-4057qib7 15575 7 % % NN cord-005453-4057qib7 15575 8 transplants transplant NNS cord-005453-4057qib7 15575 9 with with IN cord-005453-4057qib7 15575 10 11.8 11.8 CD cord-005453-4057qib7 15575 11 % % NN cord-005453-4057qib7 15575 12 regimens regimen NNS cord-005453-4057qib7 15575 13 containing contain VBG cord-005453-4057qib7 15575 14 total total JJ cord-005453-4057qib7 15575 15 body body NN cord-005453-4057qib7 15575 16 irradiation irradiation NN cord-005453-4057qib7 15575 17 . . . cord-005453-4057qib7 15576 1 Majority majority NN cord-005453-4057qib7 15576 2 of of IN cord-005453-4057qib7 15576 3 the the DT cord-005453-4057qib7 15576 4 patients patient NNS cord-005453-4057qib7 15576 5 81.3 81.3 CD cord-005453-4057qib7 15576 6 % % NN cord-005453-4057qib7 15576 7 underwent undergo VBD cord-005453-4057qib7 15576 8 allogeneic allogeneic NN cord-005453-4057qib7 15576 9 transplantation transplantation NN cord-005453-4057qib7 15576 10 using use VBG cord-005453-4057qib7 15576 11 BM BM NNP cord-005453-4057qib7 15576 12 as as IN cord-005453-4057qib7 15576 13 the the DT cord-005453-4057qib7 15576 14 source source NN cord-005453-4057qib7 15576 15 in in IN cord-005453-4057qib7 15576 16 80.4 80.4 CD cord-005453-4057qib7 15576 17 % % NN cord-005453-4057qib7 15576 18 and and CC cord-005453-4057qib7 15576 19 PBSC PBSC NNP cord-005453-4057qib7 15576 20 in in IN cord-005453-4057qib7 15576 21 the the DT cord-005453-4057qib7 15576 22 remaining remain VBG cord-005453-4057qib7 15576 23 19.6 19.6 CD cord-005453-4057qib7 15576 24 % % NN cord-005453-4057qib7 15576 25 cases case NNS cord-005453-4057qib7 15576 26 . . . cord-005453-4057qib7 15577 1 Donor donor NN cord-005453-4057qib7 15577 2 was be VBD cord-005453-4057qib7 15577 3 HLA HLA NNP cord-005453-4057qib7 15577 4 - - HYPH cord-005453-4057qib7 15577 5 Identical Identical NNP cord-005453-4057qib7 15577 6 Sibling Sibling NNP cord-005453-4057qib7 15577 7 in in IN cord-005453-4057qib7 15577 8 89 89 CD cord-005453-4057qib7 15577 9 % % NN cord-005453-4057qib7 15577 10 , , , cord-005453-4057qib7 15577 11 parents parent NNS cord-005453-4057qib7 15577 12 in in IN cord-005453-4057qib7 15577 13 10.2 10.2 CD cord-005453-4057qib7 15577 14 % % NN cord-005453-4057qib7 15577 15 and and CC cord-005453-4057qib7 15577 16 others other NNS cord-005453-4057qib7 15577 17 in in IN cord-005453-4057qib7 15577 18 the the DT cord-005453-4057qib7 15577 19 remaining remain VBG cord-005453-4057qib7 15577 20 0.9 0.9 CD cord-005453-4057qib7 15577 21 % % NN cord-005453-4057qib7 15577 22 patients patient NNS cord-005453-4057qib7 15577 23 . . . cord-005453-4057qib7 15578 1 Median median JJ cord-005453-4057qib7 15578 2 TNC TNC NNP cord-005453-4057qib7 15578 3 Dose Dose NNP cord-005453-4057qib7 15578 4 was be VBD cord-005453-4057qib7 15578 5 2.55 2.55 CD cord-005453-4057qib7 15578 6 X x SYM cord-005453-4057qib7 15578 7 10 10 CD cord-005453-4057qib7 15578 8 ^ ^ SYM cord-005453-4057qib7 15578 9 9 9 CD cord-005453-4057qib7 15579 1 and and CC cord-005453-4057qib7 15579 2 CD34 CD34 NNP cord-005453-4057qib7 15579 3 was be VBD cord-005453-4057qib7 15579 4 5.63 5.63 CD cord-005453-4057qib7 15579 5 X x SYM cord-005453-4057qib7 15579 6 10 10 CD cord-005453-4057qib7 15579 7 ^ ^ SYM cord-005453-4057qib7 15579 8 6 6 CD cord-005453-4057qib7 15579 9 per per IN cord-005453-4057qib7 15579 10 Kg Kg NNP cord-005453-4057qib7 15579 11 of of IN cord-005453-4057qib7 15579 12 the the DT cord-005453-4057qib7 15579 13 body body NN cord-005453-4057qib7 15579 14 weight weight NN cord-005453-4057qib7 15579 15 at at IN cord-005453-4057qib7 15579 16 the the DT cord-005453-4057qib7 15579 17 time time NN cord-005453-4057qib7 15579 18 of of IN cord-005453-4057qib7 15579 19 infusion infusion NN cord-005453-4057qib7 15579 20 . . . cord-005453-4057qib7 15580 1 Age age NN cord-005453-4057qib7 15580 2 and and CC cord-005453-4057qib7 15580 3 gender gender NN cord-005453-4057qib7 15580 4 specific specific JJ cord-005453-4057qib7 15580 5 BMI BMI NNP cord-005453-4057qib7 15580 6 percentiles percentile NNS cord-005453-4057qib7 15580 7 were be VBD cord-005453-4057qib7 15580 8 obtained obtain VBN cord-005453-4057qib7 15580 9 and and CC cord-005453-4057qib7 15580 10 classified classify VBN cord-005453-4057qib7 15580 11 according accord VBG cord-005453-4057qib7 15580 12 to to IN cord-005453-4057qib7 15580 13 the the DT cord-005453-4057qib7 15580 14 definition definition NN cord-005453-4057qib7 15580 15 of of IN cord-005453-4057qib7 15580 16 centers center NNS cord-005453-4057qib7 15580 17 for for IN cord-005453-4057qib7 15580 18 disease disease NN cord-005453-4057qib7 15580 19 control control NN cord-005453-4057qib7 15580 20 and and CC cord-005453-4057qib7 15580 21 prevention prevention NN cord-005453-4057qib7 15580 22 ( ( -LRB- cord-005453-4057qib7 15580 23 CDC CDC NNP cord-005453-4057qib7 15580 24 ) ) -RRB- cord-005453-4057qib7 15580 25 ; ; : cord-005453-4057qib7 15580 26 24.8 24.8 CD cord-005453-4057qib7 15580 27 % % NN cord-005453-4057qib7 15580 28 ( ( -LRB- cord-005453-4057qib7 15580 29 105 105 CD cord-005453-4057qib7 15580 30 ) ) -RRB- cord-005453-4057qib7 15580 31 recipients recipient NNS cord-005453-4057qib7 15580 32 were be VBD cord-005453-4057qib7 15580 33 categorized categorize VBN cord-005453-4057qib7 15580 34 as as IN cord-005453-4057qib7 15580 35 Under under IN cord-005453-4057qib7 15580 36 - - HYPH cord-005453-4057qib7 15580 37 Weight weight NN cord-005453-4057qib7 15580 38 , , , cord-005453-4057qib7 15580 39 61.2 61.2 CD cord-005453-4057qib7 15580 40 % % NN cord-005453-4057qib7 15580 41 ( ( -LRB- cord-005453-4057qib7 15580 42 259 259 CD cord-005453-4057qib7 15580 43 ) ) -RRB- cord-005453-4057qib7 15580 44 Normal normal JJ cord-005453-4057qib7 15580 45 , , , cord-005453-4057qib7 15580 46 5.9 5.9 CD cord-005453-4057qib7 15580 47 % % NN cord-005453-4057qib7 15580 48 ( ( -LRB- cord-005453-4057qib7 15580 49 25 25 CD cord-005453-4057qib7 15580 50 ) ) -RRB- cord-005453-4057qib7 15580 51 Over over IN cord-005453-4057qib7 15580 52 - - HYPH cord-005453-4057qib7 15580 53 Weight weight NN cord-005453-4057qib7 15580 54 and and CC cord-005453-4057qib7 15580 55 remaining remain VBG cord-005453-4057qib7 15580 56 8 8 CD cord-005453-4057qib7 15580 57 % % NN cord-005453-4057qib7 15580 58 ( ( -LRB- cord-005453-4057qib7 15580 59 34 34 CD cord-005453-4057qib7 15580 60 ) ) -RRB- cord-005453-4057qib7 15580 61 as as IN cord-005453-4057qib7 15580 62 Obese obese JJ cord-005453-4057qib7 15580 63 . . . cord-005453-4057qib7 15581 1 Results result NNS cord-005453-4057qib7 15581 2 : : : cord-005453-4057qib7 15582 1 Based base VBN cord-005453-4057qib7 15582 2 on on IN cord-005453-4057qib7 15582 3 chimeric chimeric JJ cord-005453-4057qib7 15582 4 studies study NNS cord-005453-4057qib7 15582 5 at at IN cord-005453-4057qib7 15582 6 Day-100 Day-100 NNPS cord-005453-4057qib7 15582 7 , , , cord-005453-4057qib7 15582 8 our -PRON- PRP$ cord-005453-4057qib7 15582 9 engraftment engraftment NN cord-005453-4057qib7 15582 10 rate rate NN cord-005453-4057qib7 15582 11 was be VBD cord-005453-4057qib7 15582 12 98.3 98.3 CD cord-005453-4057qib7 15582 13 % % NN cord-005453-4057qib7 15582 14 ( ( -LRB- cord-005453-4057qib7 15582 15 400 400 CD cord-005453-4057qib7 15582 16 ) ) -RRB- cord-005453-4057qib7 15582 17 out out IN cord-005453-4057qib7 15582 18 of of IN cord-005453-4057qib7 15582 19 407 407 CD cord-005453-4057qib7 15582 20 evaluable evaluable JJ cord-005453-4057qib7 15582 21 cases case NNS cord-005453-4057qib7 15582 22 . . . cord-005453-4057qib7 15583 1 Median median JJ cord-005453-4057qib7 15583 2 time time NN cord-005453-4057qib7 15583 3 to to IN cord-005453-4057qib7 15583 4 neutrophil neutrophil NN cord-005453-4057qib7 15583 5 recovery recovery NN cord-005453-4057qib7 15583 6 was be VBD cord-005453-4057qib7 15583 7 14-days 14-days CD cord-005453-4057qib7 15583 8 from from IN cord-005453-4057qib7 15583 9 infusion infusion NN cord-005453-4057qib7 15583 10 and and CC cord-005453-4057qib7 15583 11 26-days 26-days CD cord-005453-4057qib7 15583 12 for for IN cord-005453-4057qib7 15583 13 platelets platelet NNS cord-005453-4057qib7 15583 14 . . . cord-005453-4057qib7 15584 1 No no DT cord-005453-4057qib7 15584 2 statistically statistically RB cord-005453-4057qib7 15584 3 significant significant JJ cord-005453-4057qib7 15584 4 difference difference NN cord-005453-4057qib7 15584 5 was be VBD cord-005453-4057qib7 15584 6 found find VBN cord-005453-4057qib7 15584 7 for for IN cord-005453-4057qib7 15584 8 engraftment engraftment NN cord-005453-4057qib7 15584 9 rate rate NN cord-005453-4057qib7 15584 10 on on IN cord-005453-4057qib7 15584 11 D-100 d-100 NN cord-005453-4057qib7 15584 12 as as IN cord-005453-4057qib7 15584 13 it -PRON- PRP cord-005453-4057qib7 15584 14 was be VBD cord-005453-4057qib7 15584 15 100 100 CD cord-005453-4057qib7 15584 16 % % NN cord-005453-4057qib7 15584 17 ( ( -LRB- cord-005453-4057qib7 15584 18 25 25 CD cord-005453-4057qib7 15584 19 ) ) -RRB- cord-005453-4057qib7 15584 20 among among IN cord-005453-4057qib7 15584 21 98.8 98.8 CD cord-005453-4057qib7 15584 22 % % NN cord-005453-4057qib7 15584 23 ( ( -LRB- cord-005453-4057qib7 15584 24 247 247 CD cord-005453-4057qib7 15584 25 ) ) -RRB- cord-005453-4057qib7 15584 26 in in IN cord-005453-4057qib7 15584 27 Normal Normal NNP cord-005453-4057qib7 15584 28 , , , cord-005453-4057qib7 15584 29 97 97 CD cord-005453-4057qib7 15584 30 % % NN cord-005453-4057qib7 15584 31 ( ( -LRB- cord-005453-4057qib7 15584 32 97 97 CD cord-005453-4057qib7 15584 33 ) ) -RRB- cord-005453-4057qib7 15584 34 in in IN cord-005453-4057qib7 15584 35 Under Under NNP cord-005453-4057qib7 15584 36 - - HYPH cord-005453-4057qib7 15584 37 Weight weight NN cord-005453-4057qib7 15584 38 and and CC cord-005453-4057qib7 15584 39 96.9 96.9 CD cord-005453-4057qib7 15584 40 % % NN cord-005453-4057qib7 15584 41 ( ( -LRB- cord-005453-4057qib7 15584 42 31 31 CD cord-005453-4057qib7 15584 43 ) ) -RRB- cord-005453-4057qib7 15584 44 in in IN cord-005453-4057qib7 15584 45 the the DT cord-005453-4057qib7 15584 46 Obese obese JJ cord-005453-4057qib7 15584 47 ( ( -LRB- cord-005453-4057qib7 15584 48 P p NN cord-005453-4057qib7 15584 49 - - HYPH cord-005453-4057qib7 15584 50 Value value NN cord-005453-4057qib7 15584 51 : : : cord-005453-4057qib7 15584 52 0.467 0.467 CD cord-005453-4057qib7 15584 53 ) ) -RRB- cord-005453-4057qib7 15584 54 . . . cord-005453-4057qib7 15585 1 Median median JJ cord-005453-4057qib7 15585 2 time time NN cord-005453-4057qib7 15585 3 to to IN cord-005453-4057qib7 15585 4 neutrophil neutrophil NN cord-005453-4057qib7 15585 5 recovery recovery NN cord-005453-4057qib7 15585 6 from from IN cord-005453-4057qib7 15585 7 the the DT cord-005453-4057qib7 15585 8 infusion infusion NN cord-005453-4057qib7 15585 9 date date NN cord-005453-4057qib7 15585 10 was be VBD cord-005453-4057qib7 15585 11 15-days 15-days CD cord-005453-4057qib7 15585 12 in in IN cord-005453-4057qib7 15585 13 Over over JJ cord-005453-4057qib7 15585 14 - - HYPH cord-005453-4057qib7 15585 15 weight weight NN cord-005453-4057qib7 15585 16 patients patient NNS cord-005453-4057qib7 15585 17 and and CC cord-005453-4057qib7 15585 18 14 14 CD cord-005453-4057qib7 15585 19 in in IN cord-005453-4057qib7 15585 20 the the DT cord-005453-4057qib7 15585 21 remaining remain VBG cord-005453-4057qib7 15585 22 three three CD cord-005453-4057qib7 15585 23 groups group NNS cord-005453-4057qib7 15585 24 ( ( -LRB- cord-005453-4057qib7 15585 25 P P NNP cord-005453-4057qib7 15585 26 - - HYPH cord-005453-4057qib7 15585 27 Value value NN cord-005453-4057qib7 15585 28 : : : cord-005453-4057qib7 15585 29 0.841 0.841 CD cord-005453-4057qib7 15585 30 ) ) -RRB- cord-005453-4057qib7 15585 31 . . . cord-005453-4057qib7 15586 1 Acute acute JJ cord-005453-4057qib7 15586 2 Graft Graft NNP cord-005453-4057qib7 15586 3 vs. vs. IN cord-005453-4057qib7 15586 4 Host Host NNP cord-005453-4057qib7 15586 5 Disease Disease NNP cord-005453-4057qib7 15586 6 ( ( -LRB- cord-005453-4057qib7 15586 7 aGvHD agvhd NN cord-005453-4057qib7 15586 8 ) ) -RRB- cord-005453-4057qib7 15586 9 of of IN cord-005453-4057qib7 15586 10 any any DT cord-005453-4057qib7 15586 11 grade grade NN cord-005453-4057qib7 15586 12 at at IN cord-005453-4057qib7 15586 13 Day-100 Day-100 NNP cord-005453-4057qib7 15586 14 was be VBD cord-005453-4057qib7 15586 15 recorded record VBN cord-005453-4057qib7 15586 16 in in IN cord-005453-4057qib7 15586 17 19.9 19.9 CD cord-005453-4057qib7 15586 18 % % NN cord-005453-4057qib7 15586 19 ( ( -LRB- cord-005453-4057qib7 15586 20 84 84 CD cord-005453-4057qib7 15586 21 ) ) -RRB- cord-005453-4057qib7 15586 22 . . . cord-005453-4057qib7 15587 1 Any any DT cord-005453-4057qib7 15587 2 - - HYPH cord-005453-4057qib7 15587 3 grade grade NN cord-005453-4057qib7 15587 4 aGvHD agvhd NN cord-005453-4057qib7 15587 5 was be VBD cord-005453-4057qib7 15587 6 more more RBR cord-005453-4057qib7 15587 7 common common JJ cord-005453-4057qib7 15587 8 in in IN cord-005453-4057qib7 15587 9 Over Over NNP cord-005453-4057qib7 15587 10 - - HYPH cord-005453-4057qib7 15587 11 Weight weight NN cord-005453-4057qib7 15587 12 24 24 CD cord-005453-4057qib7 15587 13 % % NN cord-005453-4057qib7 15587 14 ( ( -LRB- cord-005453-4057qib7 15587 15 6 6 CD cord-005453-4057qib7 15587 16 ) ) -RRB- cord-005453-4057qib7 15587 17 , , , cord-005453-4057qib7 15587 18 followed follow VBN cord-005453-4057qib7 15587 19 by by IN cord-005453-4057qib7 15587 20 Obese Obese NNP cord-005453-4057qib7 15587 21 with with IN cord-005453-4057qib7 15587 22 23.5 23.5 CD cord-005453-4057qib7 15587 23 % % NN cord-005453-4057qib7 15587 24 ( ( -LRB- cord-005453-4057qib7 15587 25 8) 8) NNP cord-005453-4057qib7 15587 26 , , , cord-005453-4057qib7 15587 27 21 21 CD cord-005453-4057qib7 15587 28 % % NN cord-005453-4057qib7 15587 29 ( ( -LRB- cord-005453-4057qib7 15587 30 22 22 CD cord-005453-4057qib7 15587 31 ) ) -RRB- cord-005453-4057qib7 15587 32 in in IN cord-005453-4057qib7 15587 33 Under under NN cord-005453-4057qib7 15587 34 - - HYPH cord-005453-4057qib7 15587 35 weight weight NN cord-005453-4057qib7 15587 36 and and CC cord-005453-4057qib7 15587 37 18.6 18.6 CD cord-005453-4057qib7 15587 38 % % NN cord-005453-4057qib7 15587 39 ( ( -LRB- cord-005453-4057qib7 15587 40 48 48 CD cord-005453-4057qib7 15587 41 ) ) -RRB- cord-005453-4057qib7 15587 42 in in IN cord-005453-4057qib7 15587 43 Normal normal JJ cord-005453-4057qib7 15587 44 BMI BMI NNP cord-005453-4057qib7 15587 45 - - HYPH cord-005453-4057qib7 15587 46 category category NN cord-005453-4057qib7 15587 47 ( ( -LRB- cord-005453-4057qib7 15587 48 P p NN cord-005453-4057qib7 15587 49 - - HYPH cord-005453-4057qib7 15587 50 Value value NN cord-005453-4057qib7 15587 51 : : : cord-005453-4057qib7 15587 52 0.770 0.770 CD cord-005453-4057qib7 15587 53 ) ) -RRB- cord-005453-4057qib7 15587 54 . . . cord-005453-4057qib7 15588 1 Chronic chronic JJ cord-005453-4057qib7 15588 2 GvHD GvHD NNP cord-005453-4057qib7 15588 3 was be VBD cord-005453-4057qib7 15588 4 more more RBR cord-005453-4057qib7 15588 5 frequent frequent JJ cord-005453-4057qib7 15588 6 in in IN cord-005453-4057qib7 15588 7 Over Over NNP cord-005453-4057qib7 15588 8 - - HYPH cord-005453-4057qib7 15588 9 Weight weight NN cord-005453-4057qib7 15588 10 ( ( -LRB- cord-005453-4057qib7 15588 11 14.3 14.3 CD cord-005453-4057qib7 15588 12 % % NN cord-005453-4057qib7 15588 13 , , , cord-005453-4057qib7 15588 14 3 3 CD cord-005453-4057qib7 15588 15 ) ) -RRB- cord-005453-4057qib7 15588 16 , , , cord-005453-4057qib7 15588 17 compared compare VBN cord-005453-4057qib7 15588 18 to to IN cord-005453-4057qib7 15588 19 9 9 CD cord-005453-4057qib7 15588 20 ) ) -RRB- cord-005453-4057qib7 15589 1 Background background NN cord-005453-4057qib7 15589 2 : : : cord-005453-4057qib7 15589 3 Hematopoietic hematopoietic JJ cord-005453-4057qib7 15589 4 stem stem NN cord-005453-4057qib7 15589 5 cell cell NN cord-005453-4057qib7 15589 6 transplantation transplantation NN cord-005453-4057qib7 15589 7 ( ( -LRB- cord-005453-4057qib7 15589 8 HSCT HSCT NNP cord-005453-4057qib7 15589 9 ) ) -RRB- cord-005453-4057qib7 15589 10 is be VBZ cord-005453-4057qib7 15589 11 the the DT cord-005453-4057qib7 15589 12 standard standard JJ cord-005453-4057qib7 15589 13 treatment treatment NN cord-005453-4057qib7 15589 14 for for IN cord-005453-4057qib7 15589 15 children child NNS cord-005453-4057qib7 15589 16 with with IN cord-005453-4057qib7 15589 17 severe severe JJ cord-005453-4057qib7 15589 18 aplastic aplastic JJ cord-005453-4057qib7 15589 19 anemia anemia NN cord-005453-4057qib7 15589 20 ( ( -LRB- cord-005453-4057qib7 15589 21 SAA SAA NNP cord-005453-4057qib7 15589 22 ) ) -RRB- cord-005453-4057qib7 15589 23 who who WP cord-005453-4057qib7 15589 24 have have VBP cord-005453-4057qib7 15589 25 HLA HLA NNP cord-005453-4057qib7 15589 26 - - HYPH cord-005453-4057qib7 15589 27 identical identical JJ cord-005453-4057qib7 15589 28 related related JJ cord-005453-4057qib7 15589 29 donor donor NN cord-005453-4057qib7 15589 30 . . . cord-005453-4057qib7 15590 1 There there EX cord-005453-4057qib7 15590 2 is be VBZ cord-005453-4057qib7 15590 3 no no DT cord-005453-4057qib7 15590 4 standard standard JJ cord-005453-4057qib7 15590 5 conditioning conditioning NN cord-005453-4057qib7 15590 6 regimen regimen NN cord-005453-4057qib7 15590 7 for for IN cord-005453-4057qib7 15590 8 children child NNS cord-005453-4057qib7 15590 9 with with IN cord-005453-4057qib7 15590 10 SAA SAA NNP cord-005453-4057qib7 15590 11 secondary secondary JJ cord-005453-4057qib7 15590 12 to to IN cord-005453-4057qib7 15590 13 non non JJ cord-005453-4057qib7 15590 14 - - JJ cord-005453-4057qib7 15590 15 fanconi fanconi JJ cord-005453-4057qib7 15590 16 anemia anemia NN cord-005453-4057qib7 15590 17 ( ( -LRB- cord-005453-4057qib7 15590 18 FA FA NNP cord-005453-4057qib7 15590 19 ) ) -RRB- cord-005453-4057qib7 15590 20 constitutional constitutional JJ cord-005453-4057qib7 15590 21 bone bone NN cord-005453-4057qib7 15590 22 marrow marrow NN cord-005453-4057qib7 15590 23 failure failure NN cord-005453-4057qib7 15590 24 syndromes syndrome NNS cord-005453-4057qib7 15590 25 such such JJ cord-005453-4057qib7 15590 26 as as IN cord-005453-4057qib7 15590 27 telomeropathies telomeropathie NNS cord-005453-4057qib7 15590 28 . . . cord-005453-4057qib7 15591 1 We -PRON- PRP cord-005453-4057qib7 15591 2 report report VBP cord-005453-4057qib7 15591 3 the the DT cord-005453-4057qib7 15591 4 outcome outcome NN cord-005453-4057qib7 15591 5 of of IN cord-005453-4057qib7 15591 6 a a DT cord-005453-4057qib7 15591 7 consistent consistent JJ cord-005453-4057qib7 15591 8 reduced reduce VBN cord-005453-4057qib7 15591 9 intensity intensity NN cord-005453-4057qib7 15591 10 conditioning conditioning NN cord-005453-4057qib7 15591 11 regimen regimen NN cord-005453-4057qib7 15591 12 in in IN cord-005453-4057qib7 15591 13 patients patient NNS cord-005453-4057qib7 15591 14 with with IN cord-005453-4057qib7 15591 15 idiopathic idiopathic JJ cord-005453-4057qib7 15591 16 SAA SAA NNP cord-005453-4057qib7 15591 17 or or CC cord-005453-4057qib7 15591 18 inherited inherit VBN cord-005453-4057qib7 15591 19 bone bone NN cord-005453-4057qib7 15591 20 marrow marrow NN cord-005453-4057qib7 15591 21 failure failure NN cord-005453-4057qib7 15591 22 syndromes syndrome NNS cord-005453-4057qib7 15591 23 other other JJ cord-005453-4057qib7 15591 24 than than IN cord-005453-4057qib7 15591 25 FA FA NNP cord-005453-4057qib7 15591 26 who who WP cord-005453-4057qib7 15591 27 underwent undergo VBD cord-005453-4057qib7 15591 28 HLA HLA NNP cord-005453-4057qib7 15592 1 matched match VBN cord-005453-4057qib7 15592 2 related relate VBN cord-005453-4057qib7 15592 3 HSCT HSCT NNP cord-005453-4057qib7 15592 4 Methods Methods NNPS cord-005453-4057qib7 15592 5 : : : cord-005453-4057qib7 15592 6 children child NNS cord-005453-4057qib7 15592 7 with with IN cord-005453-4057qib7 15592 8 SAA SAA NNP cord-005453-4057qib7 15592 9 underwent undergo VBD cord-005453-4057qib7 15592 10 HSCT HSCT NNP cord-005453-4057qib7 15592 11 using use VBG cord-005453-4057qib7 15592 12 the the DT cord-005453-4057qib7 15592 13 following follow VBG cord-005453-4057qib7 15592 14 conditioning conditioning NN cord-005453-4057qib7 15592 15 regimen regimen NN cord-005453-4057qib7 15592 16 : : : cord-005453-4057qib7 15593 1 fludarabine fludarabine NNP cord-005453-4057qib7 15593 2 175mg 175mg NNP cord-005453-4057qib7 15593 3 / / SYM cord-005453-4057qib7 15593 4 m2 m2 NNP cord-005453-4057qib7 15593 5 , , , cord-005453-4057qib7 15593 6 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 15593 7 80 80 CD cord-005453-4057qib7 15593 8 mg mg NNP cord-005453-4057qib7 15593 9 / / SYM cord-005453-4057qib7 15593 10 m2 m2 NNP cord-005453-4057qib7 15593 11 , , , cord-005453-4057qib7 15593 12 and and CC cord-005453-4057qib7 15593 13 ATG ATG NNP cord-005453-4057qib7 15593 14 ( ( -LRB- cord-005453-4057qib7 15593 15 thymoglobulin thymoglobulin NNP cord-005453-4057qib7 15593 16 ) ) -RRB- cord-005453-4057qib7 15593 17 ( ( -LRB- cord-005453-4057qib7 15593 18 10 10 CD cord-005453-4057qib7 15593 19 mg mg NNP cord-005453-4057qib7 15593 20 / / SYM cord-005453-4057qib7 15593 21 kg kg NNP cord-005453-4057qib7 15593 22 ) ) -RRB- cord-005453-4057qib7 15593 23 . . . cord-005453-4057qib7 15594 1 GVHD GVHD NNP cord-005453-4057qib7 15594 2 prophylaxis prophylaxis NN cord-005453-4057qib7 15594 3 included include VBD cord-005453-4057qib7 15594 4 cyclosporin cyclosporin NN cord-005453-4057qib7 15594 5 and and CC cord-005453-4057qib7 15594 6 mycophenolate mycophenolate NNP cord-005453-4057qib7 15594 7 mofetil mofetil NNP cord-005453-4057qib7 15594 8 . . . cord-005453-4057qib7 15595 1 Donors donor NNS cord-005453-4057qib7 15595 2 were be VBD cord-005453-4057qib7 15595 3 all all RB cord-005453-4057qib7 15595 4 matched match VBN cord-005453-4057qib7 15595 5 related relate VBN cord-005453-4057qib7 15595 6 and and CC cord-005453-4057qib7 15595 7 bone bone NN cord-005453-4057qib7 15595 8 marrow marrow NN cord-005453-4057qib7 15595 9 was be VBD cord-005453-4057qib7 15595 10 the the DT cord-005453-4057qib7 15595 11 stem stem NN cord-005453-4057qib7 15595 12 cell cell NN cord-005453-4057qib7 15595 13 source source NN cord-005453-4057qib7 15595 14 . . . cord-005453-4057qib7 15596 1 All all DT cord-005453-4057qib7 15596 2 patients patient NNS cord-005453-4057qib7 15596 3 had have VBD cord-005453-4057qib7 15596 4 normal normal JJ cord-005453-4057qib7 15596 5 chromosomal chromosomal JJ cord-005453-4057qib7 15596 6 fragility fragility NN cord-005453-4057qib7 15596 7 testResults testResults NNP cord-005453-4057qib7 15596 8 : : : cord-005453-4057qib7 15596 9 a a DT cord-005453-4057qib7 15596 10 total total NN cord-005453-4057qib7 15596 11 of of IN cord-005453-4057qib7 15596 12 18 18 CD cord-005453-4057qib7 15596 13 children child NNS cord-005453-4057qib7 15596 14 with with IN cord-005453-4057qib7 15596 15 SAA SAA NNP cord-005453-4057qib7 15596 16 underwent undergo VBD cord-005453-4057qib7 15596 17 HSCT HSCT NNP cord-005453-4057qib7 15596 18 , , , cord-005453-4057qib7 15596 19 12 12 CD cord-005453-4057qib7 15596 20 females female NNS cord-005453-4057qib7 15596 21 and and CC cord-005453-4057qib7 15596 22 6 6 CD cord-005453-4057qib7 15596 23 males male NNS cord-005453-4057qib7 15596 24 . . . cord-005453-4057qib7 15597 1 Average average JJ cord-005453-4057qib7 15597 2 age age NN cord-005453-4057qib7 15597 3 was be VBD cord-005453-4057qib7 15597 4 8.1 8.1 CD cord-005453-4057qib7 15597 5 ( ( -LRB- cord-005453-4057qib7 15597 6 range range VB cord-005453-4057qib7 15597 7 0.8 0.8 CD cord-005453-4057qib7 15597 8 - - HYPH cord-005453-4057qib7 15597 9 13.8 13.8 CD cord-005453-4057qib7 15597 10 years year NNS cord-005453-4057qib7 15597 11 ) ) -RRB- cord-005453-4057qib7 15597 12 . . . cord-005453-4057qib7 15598 1 All all DT cord-005453-4057qib7 15598 2 nine nine CD cord-005453-4057qib7 15598 3 patients patient NNS cord-005453-4057qib7 15598 4 who who WP cord-005453-4057qib7 15598 5 were be VBD cord-005453-4057qib7 15598 6 tested test VBN cord-005453-4057qib7 15598 7 for for IN cord-005453-4057qib7 15598 8 telomere telomere NN cord-005453-4057qib7 15598 9 length length NN cord-005453-4057qib7 15598 10 had have VBD cord-005453-4057qib7 15598 11 short short JJ cord-005453-4057qib7 15598 12 telomeres telomere NNS cord-005453-4057qib7 15598 13 . . . cord-005453-4057qib7 15599 1 Pathogenic pathogenic JJ cord-005453-4057qib7 15599 2 or or CC cord-005453-4057qib7 15599 3 likely likely JJ cord-005453-4057qib7 15599 4 pathogenic pathogenic JJ cord-005453-4057qib7 15599 5 mutations mutation NNS cord-005453-4057qib7 15599 6 were be VBD cord-005453-4057qib7 15599 7 reported report VBN cord-005453-4057qib7 15599 8 in in IN cord-005453-4057qib7 15599 9 5 5 CD cord-005453-4057qib7 15599 10 patients patient NNS cord-005453-4057qib7 15599 11 ( ( -LRB- cord-005453-4057qib7 15599 12 2 2 CD cord-005453-4057qib7 15599 13 ERCC6L2 ERCC6L2 NNP cord-005453-4057qib7 15599 14 , , , cord-005453-4057qib7 15599 15 1 1 CD cord-005453-4057qib7 15599 16 ANKRD26 ANKRD26 NNS cord-005453-4057qib7 15599 17 , , , cord-005453-4057qib7 15599 18 1 1 CD cord-005453-4057qib7 15599 19 TINF2 tinf2 NN cord-005453-4057qib7 15599 20 , , , cord-005453-4057qib7 15599 21 1 1 CD cord-005453-4057qib7 15599 22 LZTFL1 LZTFL1 NNP cord-005453-4057qib7 15599 23 ) ) -RRB- cord-005453-4057qib7 15599 24 . . . cord-005453-4057qib7 15600 1 All all DT cord-005453-4057qib7 15600 2 donors donor NNS cord-005453-4057qib7 15600 3 had have VBD cord-005453-4057qib7 15600 4 normal normal JJ cord-005453-4057qib7 15600 5 physical physical JJ cord-005453-4057qib7 15600 6 examination examination NN cord-005453-4057qib7 15600 7 , , , cord-005453-4057qib7 15600 8 normal normal JJ cord-005453-4057qib7 15600 9 CBC CBC NNP cord-005453-4057qib7 15600 10 , , , cord-005453-4057qib7 15600 11 and and CC cord-005453-4057qib7 15600 12 negative negative JJ cord-005453-4057qib7 15600 13 genetic genetic JJ cord-005453-4057qib7 15600 14 testing testing NN cord-005453-4057qib7 15600 15 if if IN cord-005453-4057qib7 15600 16 patient patient JJ cord-005453-4057qib7 15600 17 mutation mutation NN cord-005453-4057qib7 15600 18 is be VBZ cord-005453-4057qib7 15600 19 known know VBN cord-005453-4057qib7 15600 20 . . . cord-005453-4057qib7 15601 1 All all DT cord-005453-4057qib7 15601 2 18 18 CD cord-005453-4057qib7 15601 3 patients patient NNS cord-005453-4057qib7 15601 4 engrafted engraft VBN cord-005453-4057qib7 15601 5 successfully successfully RB cord-005453-4057qib7 15601 6 , , , cord-005453-4057qib7 15601 7 median median JJ cord-005453-4057qib7 15601 8 time time NN cord-005453-4057qib7 15601 9 to to IN cord-005453-4057qib7 15601 10 neutrophil neutrophil NN cord-005453-4057qib7 15601 11 engraftment engraftment NN cord-005453-4057qib7 15601 12 was be VBD cord-005453-4057qib7 15601 13 16 16 CD cord-005453-4057qib7 15602 1 ( ( -LRB- cord-005453-4057qib7 15602 2 range range NN cord-005453-4057qib7 15602 3 , , , cord-005453-4057qib7 15602 4 11 11 CD cord-005453-4057qib7 15602 5 - - SYM cord-005453-4057qib7 15602 6 29 29 CD cord-005453-4057qib7 15602 7 days day NNS cord-005453-4057qib7 15602 8 ) ) -RRB- cord-005453-4057qib7 15602 9 and and CC cord-005453-4057qib7 15602 10 platelet platelet NN cord-005453-4057qib7 15602 11 engraftment engraftment NN cord-005453-4057qib7 15602 12 19 19 CD cord-005453-4057qib7 15602 13 ( ( -LRB- cord-005453-4057qib7 15602 14 range range NN cord-005453-4057qib7 15602 15 , , , cord-005453-4057qib7 15602 16 13 13 CD cord-005453-4057qib7 15602 17 - - SYM cord-005453-4057qib7 15602 18 45 45 CD cord-005453-4057qib7 15602 19 days day NNS cord-005453-4057qib7 15602 20 ) ) -RRB- cord-005453-4057qib7 15602 21 . . . cord-005453-4057qib7 15603 1 Median median JJ cord-005453-4057qib7 15603 2 infused infuse VBN cord-005453-4057qib7 15603 3 nucleated nucleated JJ cord-005453-4057qib7 15603 4 cell cell NN cord-005453-4057qib7 15603 5 dose dose NN cord-005453-4057qib7 15603 6 was be VBD cord-005453-4057qib7 15604 1 3.3 3.3 LS cord-005453-4057qib7 15604 2 ( ( -LRB- cord-005453-4057qib7 15604 3 range,0.9 range,0.9 NN cord-005453-4057qib7 15604 4 - - HYPH cord-005453-4057qib7 15604 5 7.3 7.3 CD cord-005453-4057qib7 15604 6 X10 X10 NNP cord-005453-4057qib7 15604 7 8 8 CD cord-005453-4057qib7 15604 8 /kg /kg . cord-005453-4057qib7 15604 9 ) ) -RRB- cord-005453-4057qib7 15605 1 and and CC cord-005453-4057qib7 15605 2 CD34 CD34 NNP cord-005453-4057qib7 15605 3 cell cell NN cord-005453-4057qib7 15605 4 dose dose NN cord-005453-4057qib7 15605 5 was be VBD cord-005453-4057qib7 15605 6 6.7 6.7 CD cord-005453-4057qib7 15605 7 ( ( -LRB- cord-005453-4057qib7 15605 8 range range NN cord-005453-4057qib7 15605 9 , , , cord-005453-4057qib7 15605 10 1.1 1.1 CD cord-005453-4057qib7 15605 11 - - SYM cord-005453-4057qib7 15605 12 13.1 13.1 CD cord-005453-4057qib7 15605 13 X10 X10 NNP cord-005453-4057qib7 15605 14 6 6 CD cord-005453-4057qib7 15605 15 /kg /kg . cord-005453-4057qib7 15605 16 ) ) -RRB- cord-005453-4057qib7 15605 17 . . . cord-005453-4057qib7 15606 1 None none NN cord-005453-4057qib7 15606 2 of of IN cord-005453-4057qib7 15606 3 our -PRON- PRP$ cord-005453-4057qib7 15606 4 patients patient NNS cord-005453-4057qib7 15606 5 had have VBD cord-005453-4057qib7 15606 6 acute acute JJ cord-005453-4057qib7 15606 7 GVHD GVHD NNP cord-005453-4057qib7 15606 8 and and CC cord-005453-4057qib7 15606 9 one one CD cord-005453-4057qib7 15606 10 patient patient NN cord-005453-4057qib7 15606 11 had have VBD cord-005453-4057qib7 15606 12 mild mild JJ cord-005453-4057qib7 15606 13 classic classic JJ cord-005453-4057qib7 15606 14 chronic chronic JJ cord-005453-4057qib7 15606 15 GVHD gvhd NN cord-005453-4057qib7 15606 16 of of IN cord-005453-4057qib7 15606 17 the the DT cord-005453-4057qib7 15606 18 skin skin NN cord-005453-4057qib7 15606 19 that that WDT cord-005453-4057qib7 15606 20 was be VBD cord-005453-4057qib7 15606 21 controlled control VBN cord-005453-4057qib7 15606 22 with with IN cord-005453-4057qib7 15606 23 topical topical JJ cord-005453-4057qib7 15606 24 therapy therapy NN cord-005453-4057qib7 15606 25 for for IN cord-005453-4057qib7 15606 26 a a DT cord-005453-4057qib7 15606 27 short short JJ cord-005453-4057qib7 15606 28 period period NN cord-005453-4057qib7 15606 29 . . . cord-005453-4057qib7 15607 1 Three three CD cord-005453-4057qib7 15607 2 patients patient NNS cord-005453-4057qib7 15607 3 had have VBD cord-005453-4057qib7 15607 4 secondary secondary JJ cord-005453-4057qib7 15607 5 graft graft NN cord-005453-4057qib7 15607 6 failure failure NN cord-005453-4057qib7 15607 7 in in IN cord-005453-4057qib7 15607 8 the the DT cord-005453-4057qib7 15607 9 first first JJ cord-005453-4057qib7 15607 10 - - HYPH cord-005453-4057qib7 15607 11 year year NN cord-005453-4057qib7 15607 12 post post NN cord-005453-4057qib7 15607 13 transplant transplant NN cord-005453-4057qib7 15607 14 . . . cord-005453-4057qib7 15608 1 First first JJ cord-005453-4057qib7 15608 2 patient patient NN cord-005453-4057qib7 15608 3 had have VBD cord-005453-4057qib7 15608 4 pancytopenia pancytopenia VBN cord-005453-4057qib7 15608 5 with with IN cord-005453-4057qib7 15608 6 loss loss NN cord-005453-4057qib7 15608 7 of of IN cord-005453-4057qib7 15608 8 donor donor NN cord-005453-4057qib7 15608 9 chimerism chimerism NN cord-005453-4057qib7 15608 10 and and CC cord-005453-4057qib7 15608 11 underwent undergo VBD cord-005453-4057qib7 15608 12 successful successful JJ cord-005453-4057qib7 15608 13 second second JJ cord-005453-4057qib7 15608 14 transplant transplant NN cord-005453-4057qib7 15608 15 using use VBG cord-005453-4057qib7 15608 16 fludarabine fludarabine NN cord-005453-4057qib7 15608 17 , , , cord-005453-4057qib7 15608 18 ATG ATG NNP cord-005453-4057qib7 15608 19 , , , cord-005453-4057qib7 15608 20 and and CC cord-005453-4057qib7 15608 21 melphalan melphalan NNP cord-005453-4057qib7 15608 22 . . . cord-005453-4057qib7 15609 1 The the DT cord-005453-4057qib7 15609 2 second second JJ cord-005453-4057qib7 15609 3 patient patient NN cord-005453-4057qib7 15609 4 had have VBD cord-005453-4057qib7 15609 5 a a DT cord-005453-4057qib7 15609 6 nonfunctioning nonfunctioning JJ cord-005453-4057qib7 15609 7 graft graft NN cord-005453-4057qib7 15609 8 despite despite IN cord-005453-4057qib7 15609 9 full full JJ cord-005453-4057qib7 15609 10 donor donor NN cord-005453-4057qib7 15609 11 chimerism chimerism NN cord-005453-4057qib7 15609 12 suggesting suggest VBG cord-005453-4057qib7 15609 13 that that IN cord-005453-4057qib7 15609 14 the the DT cord-005453-4057qib7 15609 15 related related JJ cord-005453-4057qib7 15609 16 donor donor NN cord-005453-4057qib7 15609 17 might may MD cord-005453-4057qib7 15609 18 be be VB cord-005453-4057qib7 15609 19 affected affect VBN cord-005453-4057qib7 15609 20 and and CC cord-005453-4057qib7 15609 21 had have VBD cord-005453-4057qib7 15609 22 silent silent JJ cord-005453-4057qib7 15609 23 phenotype phenotype NN cord-005453-4057qib7 15609 24 . . . cord-005453-4057qib7 15610 1 The the DT cord-005453-4057qib7 15610 2 third third JJ cord-005453-4057qib7 15610 3 patient patient NN cord-005453-4057qib7 15610 4 had have VBD cord-005453-4057qib7 15610 5 homozygous homozygous JJ cord-005453-4057qib7 15610 6 ERCC6L2 ercc6l2 CD cord-005453-4057qib7 15610 7 mutation mutation NN cord-005453-4057qib7 15610 8 and and CC cord-005453-4057qib7 15610 9 developed develop VBD cord-005453-4057qib7 15610 10 progressive progressive JJ cord-005453-4057qib7 15610 11 cytopenia cytopenia NNS cord-005453-4057qib7 15610 12 with with IN cord-005453-4057qib7 15610 13 myelodysplastic myelodysplastic NN cord-005453-4057qib7 15610 14 features feature VBZ cord-005453-4057qib7 15610 15 few few JJ cord-005453-4057qib7 15610 16 months month NNS cord-005453-4057qib7 15610 17 post post NN cord-005453-4057qib7 15610 18 - - NN cord-005453-4057qib7 15610 19 transplant transplant JJ cord-005453-4057qib7 15610 20 and and CC cord-005453-4057qib7 15610 21 subsequently subsequently RB cord-005453-4057qib7 15610 22 underwent undergo VBD cord-005453-4057qib7 15610 23 myeloablative myeloablative NNP cord-005453-4057qib7 15610 24 matched match VBN cord-005453-4057qib7 15610 25 unrelated unrelated JJ cord-005453-4057qib7 15610 26 transplant transplant NN cord-005453-4057qib7 15610 27 using use VBG cord-005453-4057qib7 15610 28 busulfan busulfan NN cord-005453-4057qib7 15610 29 , , , cord-005453-4057qib7 15610 30 fludarabine fludarabine NN cord-005453-4057qib7 15610 31 , , , cord-005453-4057qib7 15610 32 thiotepa thiotepa NNP cord-005453-4057qib7 15610 33 and and CC cord-005453-4057qib7 15610 34 ATG ATG NNP cord-005453-4057qib7 15610 35 . . . cord-005453-4057qib7 15611 1 However however RB cord-005453-4057qib7 15611 2 , , , cord-005453-4057qib7 15611 3 the the DT cord-005453-4057qib7 15611 4 patient patient NN cord-005453-4057qib7 15611 5 progressed progress VBD cord-005453-4057qib7 15611 6 to to TO cord-005453-4057qib7 15611 7 have have VB cord-005453-4057qib7 15611 8 acute acute JJ cord-005453-4057qib7 15611 9 myeloid myeloid NN cord-005453-4057qib7 15611 10 leukemia leukemia NN cord-005453-4057qib7 15612 1 six six CD cord-005453-4057qib7 15612 2 months month NNS cord-005453-4057qib7 15612 3 post post NN cord-005453-4057qib7 15612 4 HSCT HSCT NNP cord-005453-4057qib7 15612 5 . . . cord-005453-4057qib7 15613 1 Fifteen fifteen CD cord-005453-4057qib7 15613 2 patients patient NNS cord-005453-4057qib7 15613 3 ( ( -LRB- cord-005453-4057qib7 15613 4 83 83 CD cord-005453-4057qib7 15613 5 % % NN cord-005453-4057qib7 15613 6 ) ) -RRB- cord-005453-4057qib7 15613 7 have have VBP cord-005453-4057qib7 15613 8 normal normal JJ cord-005453-4057qib7 15613 9 CBC CBC NNP cord-005453-4057qib7 15613 10 and and CC cord-005453-4057qib7 15613 11 stable stable JJ cord-005453-4057qib7 15613 12 donor donor NN cord-005453-4057qib7 15613 13 chimerism chimerism NN cord-005453-4057qib7 15613 14 . . . cord-005453-4057qib7 15614 1 Median median JJ cord-005453-4057qib7 15614 2 follow follow NN cord-005453-4057qib7 15614 3 - - HYPH cord-005453-4057qib7 15614 4 up up RP cord-005453-4057qib7 15614 5 duration duration NN cord-005453-4057qib7 15614 6 of of IN cord-005453-4057qib7 15614 7 1140 1140 CD cord-005453-4057qib7 15614 8 days day NNS cord-005453-4057qib7 15614 9 ( ( -LRB- cord-005453-4057qib7 15614 10 range range VBP cord-005453-4057qib7 15614 11 330 330 CD cord-005453-4057qib7 15614 12 -2595 -2595 HYPH cord-005453-4057qib7 15614 13 days day NNS cord-005453-4057qib7 15614 14 ) ) -RRB- cord-005453-4057qib7 15614 15 . . . cord-005453-4057qib7 15615 1 One one CD cord-005453-4057qib7 15615 2 patient patient NN cord-005453-4057qib7 15615 3 with with IN cord-005453-4057qib7 15615 4 LZTFL1 LZTFL1 NNP cord-005453-4057qib7 15615 5 mutation mutation NN cord-005453-4057qib7 15615 6 developed develop VBD cord-005453-4057qib7 15615 7 chronic chronic JJ cord-005453-4057qib7 15615 8 renal renal JJ cord-005453-4057qib7 15615 9 impairment impairment NN cord-005453-4057qib7 15616 1 five five CD cord-005453-4057qib7 15616 2 years year NNS cord-005453-4057qib7 15616 3 post post VBP cord-005453-4057qib7 15616 4 HSCT.Conclusions hsct.conclusion NNS cord-005453-4057qib7 15616 5 : : : cord-005453-4057qib7 15616 6 HSCT HSCT NNP cord-005453-4057qib7 15616 7 using use VBG cord-005453-4057qib7 15616 8 lower low JJR cord-005453-4057qib7 15616 9 dose dose NN cord-005453-4057qib7 15616 10 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 15616 11 ( ( -LRB- cord-005453-4057qib7 15616 12 80mg 80mg NN cord-005453-4057qib7 15616 13 / / SYM cord-005453-4057qib7 15616 14 kg kg NNP cord-005453-4057qib7 15616 15 ) ) -RRB- cord-005453-4057qib7 15616 16 as as IN cord-005453-4057qib7 15616 17 part part NN cord-005453-4057qib7 15616 18 of of IN cord-005453-4057qib7 15616 19 fludarabine fludarabine NN cord-005453-4057qib7 15616 20 based base VBN cord-005453-4057qib7 15616 21 regimen regimen NN cord-005453-4057qib7 15616 22 was be VBD cord-005453-4057qib7 15616 23 safe safe JJ cord-005453-4057qib7 15616 24 and and CC cord-005453-4057qib7 15616 25 effective effective JJ cord-005453-4057qib7 15616 26 in in IN cord-005453-4057qib7 15616 27 SAA SAA NNP cord-005453-4057qib7 15616 28 patients patient NNS cord-005453-4057qib7 15616 29 with with IN cord-005453-4057qib7 15616 30 shorter short JJR cord-005453-4057qib7 15616 31 telomeres telomere NNS cord-005453-4057qib7 15616 32 and and CC cord-005453-4057qib7 15616 33 described describe VBD cord-005453-4057qib7 15616 34 genetic genetic JJ cord-005453-4057qib7 15616 35 abnormalities abnormality NNS cord-005453-4057qib7 15616 36 . . . cord-005453-4057qib7 15617 1 Optimal optimal JJ cord-005453-4057qib7 15617 2 conditioning conditioning NN cord-005453-4057qib7 15617 3 regimen regimen NN cord-005453-4057qib7 15617 4 in in IN cord-005453-4057qib7 15617 5 ERCC6L2-associated ercc6l2-associate VBN cord-005453-4057qib7 15617 6 bone bone NN cord-005453-4057qib7 15617 7 marrow marrow NN cord-005453-4057qib7 15617 8 failure failure NN cord-005453-4057qib7 15617 9 needs need VBZ cord-005453-4057qib7 15617 10 to to TO cord-005453-4057qib7 15617 11 be be VB cord-005453-4057qib7 15617 12 defined define VBN cord-005453-4057qib7 15617 13 . . . cord-005453-4057qib7 15618 1 Larger large JJR cord-005453-4057qib7 15618 2 study study NN cord-005453-4057qib7 15618 3 is be VBZ cord-005453-4057qib7 15618 4 needed need VBN cord-005453-4057qib7 15618 5 to to TO cord-005453-4057qib7 15618 6 confirm confirm VB cord-005453-4057qib7 15618 7 our -PRON- PRP$ cord-005453-4057qib7 15618 8 results result NNS cord-005453-4057qib7 15618 9 . . . cord-005453-4057qib7 15619 1 Clinical clinical JJ cord-005453-4057qib7 15619 2 Trial Trial NNP cord-005453-4057qib7 15619 3 Registry Registry NNP cord-005453-4057qib7 15619 4 : : : cord-005453-4057qib7 15620 1 Not not RB cord-005453-4057qib7 15620 2 applicable applicable JJ cord-005453-4057qib7 15620 3 Disclosure disclosure NN cord-005453-4057qib7 15620 4 : : : cord-005453-4057qib7 15621 1 Nothing nothing NN cord-005453-4057qib7 15621 2 to to TO cord-005453-4057qib7 15621 3 declare declare VB cord-005453-4057qib7 15621 4 Late late JJ cord-005453-4057qib7 15621 5 effects effect NNS cord-005453-4057qib7 15621 6 in in IN cord-005453-4057qib7 15621 7 patients patient NNS cord-005453-4057qib7 15621 8 with with IN cord-005453-4057qib7 15621 9 hemophagocytic hemophagocytic JJ cord-005453-4057qib7 15621 10 lymphohistiocytosis lymphohistiocytosis NNP cord-005453-4057qib7 15621 11 treated treat VBN cord-005453-4057qib7 15621 12 with with IN cord-005453-4057qib7 15621 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 15621 14 stem stem NN cord-005453-4057qib7 15621 15 cell cell NN cord-005453-4057qib7 15621 16 transplantation transplantation NN cord-005453-4057qib7 15621 17 : : : cord-005453-4057qib7 15621 18 A a DT cord-005453-4057qib7 15621 19 review review NN cord-005453-4057qib7 15621 20 of of IN cord-005453-4057qib7 15621 21 the the DT cord-005453-4057qib7 15621 22 literature literature NN cord-005453-4057qib7 15621 23 Background background NN cord-005453-4057qib7 15621 24 : : : cord-005453-4057qib7 15621 25 Hemophagocytic hemophagocytic JJ cord-005453-4057qib7 15621 26 lymphohistiocytosis lymphohistiocytosis NN cord-005453-4057qib7 15621 27 ( ( -LRB- cord-005453-4057qib7 15621 28 HLH HLH NNP cord-005453-4057qib7 15621 29 ) ) -RRB- cord-005453-4057qib7 15621 30 is be VBZ cord-005453-4057qib7 15621 31 an an DT cord-005453-4057qib7 15621 32 inherited inherit VBN cord-005453-4057qib7 15621 33 or or CC cord-005453-4057qib7 15621 34 acquired acquire VBN cord-005453-4057qib7 15621 35 disorder disorder NN cord-005453-4057qib7 15621 36 of of IN cord-005453-4057qib7 15621 37 immunedysregulation immunedysregulation NN cord-005453-4057qib7 15621 38 . . . cord-005453-4057qib7 15622 1 Early early JJ cord-005453-4057qib7 15622 2 diagnosis diagnosis NN cord-005453-4057qib7 15622 3 and and CC cord-005453-4057qib7 15622 4 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 15622 5 treatment treatment NN cord-005453-4057qib7 15622 6 can can MD cord-005453-4057qib7 15622 7 prevent prevent VB cord-005453-4057qib7 15622 8 significant significant JJ cord-005453-4057qib7 15622 9 organ organ NN cord-005453-4057qib7 15622 10 - - HYPH cord-005453-4057qib7 15622 11 failure failure NN cord-005453-4057qib7 15622 12 . . . cord-005453-4057qib7 15623 1 The the DT cord-005453-4057qib7 15623 2 inherited inherit VBN cord-005453-4057qib7 15623 3 forms form NNS cord-005453-4057qib7 15623 4 , , , cord-005453-4057qib7 15623 5 and and CC cord-005453-4057qib7 15623 6 some some DT cord-005453-4057qib7 15623 7 acquired acquire VBN cord-005453-4057qib7 15623 8 cases case NNS cord-005453-4057qib7 15623 9 can can MD cord-005453-4057qib7 15623 10 only only RB cord-005453-4057qib7 15623 11 be be VB cord-005453-4057qib7 15623 12 cured cure VBN cord-005453-4057qib7 15623 13 by by IN cord-005453-4057qib7 15623 14 hematopoietic hematopoietic JJ cord-005453-4057qib7 15623 15 stem stem NN cord-005453-4057qib7 15623 16 cell cell NN cord-005453-4057qib7 15623 17 transplantation transplantation NN cord-005453-4057qib7 15623 18 ( ( -LRB- cord-005453-4057qib7 15623 19 HSCT HSCT NNP cord-005453-4057qib7 15623 20 ) ) -RRB- cord-005453-4057qib7 15623 21 . . . cord-005453-4057qib7 15624 1 With with IN cord-005453-4057qib7 15624 2 modern modern JJ cord-005453-4057qib7 15624 3 transplant transplant NN cord-005453-4057qib7 15624 4 practices practice NNS cord-005453-4057qib7 15624 5 , , , cord-005453-4057qib7 15624 6 a a DT cord-005453-4057qib7 15624 7 significant significant JJ cord-005453-4057qib7 15624 8 number number NN cord-005453-4057qib7 15624 9 of of IN cord-005453-4057qib7 15624 10 patients patient NNS cord-005453-4057qib7 15624 11 survive survive VBP cord-005453-4057qib7 15624 12 . . . cord-005453-4057qib7 15625 1 The the DT cord-005453-4057qib7 15625 2 purpose purpose NN cord-005453-4057qib7 15625 3 of of IN cord-005453-4057qib7 15625 4 this this DT cord-005453-4057qib7 15625 5 literature literature NN cord-005453-4057qib7 15625 6 review review NN cord-005453-4057qib7 15625 7 was be VBD cord-005453-4057qib7 15625 8 to to TO cord-005453-4057qib7 15625 9 collect collect VB cord-005453-4057qib7 15625 10 data datum NNS cord-005453-4057qib7 15625 11 on on IN cord-005453-4057qib7 15625 12 the the DT cord-005453-4057qib7 15625 13 frequency frequency NN cord-005453-4057qib7 15625 14 and and CC cord-005453-4057qib7 15625 15 type type NN cord-005453-4057qib7 15625 16 of of IN cord-005453-4057qib7 15625 17 late late JJ cord-005453-4057qib7 15625 18 effects effect NNS cord-005453-4057qib7 15625 19 in in IN cord-005453-4057qib7 15625 20 HLH HLH NNP cord-005453-4057qib7 15625 21 patients patient NNS cord-005453-4057qib7 15625 22 surviving survive VBG cord-005453-4057qib7 15625 23 after after IN cord-005453-4057qib7 15625 24 HSCT HSCT NNP cord-005453-4057qib7 15625 25 and and CC cord-005453-4057qib7 15625 26 to to TO cord-005453-4057qib7 15625 27 examine examine VB cord-005453-4057qib7 15625 28 the the DT cord-005453-4057qib7 15625 29 association association NN cord-005453-4057qib7 15625 30 with with IN cord-005453-4057qib7 15625 31 pre pre JJ cord-005453-4057qib7 15625 32 - - JJ cord-005453-4057qib7 15625 33 existing existing JJ cord-005453-4057qib7 15625 34 HLH HLH NNP cord-005453-4057qib7 15625 35 conditions condition NNS cord-005453-4057qib7 15625 36 ( ( -LRB- cord-005453-4057qib7 15625 37 eg eg IN cord-005453-4057qib7 15625 38 . . . cord-005453-4057qib7 15625 39 involvement involvement NN cord-005453-4057qib7 15625 40 of of IN cord-005453-4057qib7 15625 41 the the DT cord-005453-4057qib7 15625 42 central central JJ cord-005453-4057qib7 15625 43 nervous nervous JJ cord-005453-4057qib7 15625 44 system system NN cord-005453-4057qib7 15625 45 ( ( -LRB- cord-005453-4057qib7 15625 46 CNS CNS NNP cord-005453-4057qib7 15625 47 ) ) -RRB- cord-005453-4057qib7 15625 48 before before IN cord-005453-4057qib7 15625 49 transplant transplant NN cord-005453-4057qib7 15625 50 ) ) -RRB- cord-005453-4057qib7 15625 51 and and CC cord-005453-4057qib7 15625 52 with with IN cord-005453-4057qib7 15625 53 the the DT cord-005453-4057qib7 15625 54 pre pre JJ cord-005453-4057qib7 15625 55 - - JJ cord-005453-4057qib7 15625 56 transplant transplant JJ cord-005453-4057qib7 15625 57 conditioning conditioning NN cord-005453-4057qib7 15625 58 regimens regimen NNS cord-005453-4057qib7 15625 59 . . . cord-005453-4057qib7 15626 1 Methods method NNS cord-005453-4057qib7 15626 2 : : : cord-005453-4057qib7 15626 3 The the DT cord-005453-4057qib7 15626 4 MEDLINE MEDLINE NNP cord-005453-4057qib7 15626 5 , , , cord-005453-4057qib7 15626 6 EMBASE EMBASE NNP cord-005453-4057qib7 15626 7 , , , cord-005453-4057qib7 15626 8 Web web NN cord-005453-4057qib7 15626 9 of of IN cord-005453-4057qib7 15626 10 Science Science NNP cord-005453-4057qib7 15626 11 and and CC cord-005453-4057qib7 15626 12 PubMed PubMed NNP cord-005453-4057qib7 15626 13 databases database NNS cord-005453-4057qib7 15626 14 were be VBD cord-005453-4057qib7 15626 15 searched search VBN cord-005453-4057qib7 15626 16 , , , cord-005453-4057qib7 15626 17 by by IN cord-005453-4057qib7 15626 18 two two CD cord-005453-4057qib7 15626 19 librarians librarian NNS cord-005453-4057qib7 15626 20 at at IN cord-005453-4057qib7 15626 21 the the DT cord-005453-4057qib7 15626 22 Karolinska Karolinska NNP cord-005453-4057qib7 15626 23 Institutet Institutet NNP cord-005453-4057qib7 15626 24 , , , cord-005453-4057qib7 15626 25 between between IN cord-005453-4057qib7 15626 26 May May NNP cord-005453-4057qib7 15626 27 and and CC cord-005453-4057qib7 15626 28 September September NNP cord-005453-4057qib7 15626 29 2016 2016 CD cord-005453-4057qib7 15626 30 according accord VBG cord-005453-4057qib7 15626 31 to to IN cord-005453-4057qib7 15626 32 the the DT cord-005453-4057qib7 15626 33 Preferred Preferred NNP cord-005453-4057qib7 15626 34 Reporting Reporting NNP cord-005453-4057qib7 15626 35 Items Items NNP cord-005453-4057qib7 15626 36 for for IN cord-005453-4057qib7 15626 37 Systematic Systematic NNP cord-005453-4057qib7 15626 38 Review Review NNP cord-005453-4057qib7 15626 39 and and CC cord-005453-4057qib7 15626 40 Meta Meta NNP cord-005453-4057qib7 15626 41 - - HYPH cord-005453-4057qib7 15626 42 analysis analysis NN cord-005453-4057qib7 15626 43 ( ( -LRB- cord-005453-4057qib7 15626 44 PRISMA PRISMA NNP cord-005453-4057qib7 15626 45 ) ) -RRB- cord-005453-4057qib7 15626 46 statement statement NN cord-005453-4057qib7 15626 47 . . . cord-005453-4057qib7 15627 1 The the DT cord-005453-4057qib7 15627 2 search search NN cord-005453-4057qib7 15627 3 terms term NNS cord-005453-4057qib7 15627 4 included include VBD cord-005453-4057qib7 15627 5 " " `` cord-005453-4057qib7 15627 6 HLH HLH NNP cord-005453-4057qib7 15627 7 " " '' cord-005453-4057qib7 15627 8 , , , cord-005453-4057qib7 15627 9 " " `` cord-005453-4057qib7 15627 10 FHL FHL NNP cord-005453-4057qib7 15627 11 " " '' cord-005453-4057qib7 15627 12 , , , cord-005453-4057qib7 15627 13 " " `` cord-005453-4057qib7 15627 14 MAS MAS NNP cord-005453-4057qib7 15627 15 " " '' cord-005453-4057qib7 15627 16 , , , cord-005453-4057qib7 15627 17 multiple multiple JJ cord-005453-4057qib7 15627 18 terms term NNS cord-005453-4057qib7 15627 19 for for IN cord-005453-4057qib7 15627 20 " " `` cord-005453-4057qib7 15627 21 HSCT HSCT NNP cord-005453-4057qib7 15627 22 " " '' cord-005453-4057qib7 15627 23 and and CC cord-005453-4057qib7 15627 24 late late JJ cord-005453-4057qib7 15627 25 - - HYPH cord-005453-4057qib7 15627 26 effect effect NN cord-005453-4057qib7 15627 27 conditions condition NNS cord-005453-4057qib7 15627 28 . . . cord-005453-4057qib7 15628 1 Inclusion inclusion NN cord-005453-4057qib7 15628 2 criteria criterion NNS cord-005453-4057qib7 15628 3 were be VBD cord-005453-4057qib7 15628 4 publications publication NNS cord-005453-4057qib7 15628 5 in in IN cord-005453-4057qib7 15628 6 English English NNP cord-005453-4057qib7 15628 7 that that WDT cord-005453-4057qib7 15628 8 included include VBD cord-005453-4057qib7 15628 9 children child NNS cord-005453-4057qib7 15628 10 between between IN cord-005453-4057qib7 15628 11 January January NNP cord-005453-4057qib7 15628 12 1995 1995 CD cord-005453-4057qib7 15628 13 and and CC cord-005453-4057qib7 15628 14 May May NNP cord-005453-4057qib7 15628 15 2016 2016 CD cord-005453-4057qib7 15628 16 . . . cord-005453-4057qib7 15629 1 Authors author NNS cord-005453-4057qib7 15629 2 of of IN cord-005453-4057qib7 15629 3 this this DT cord-005453-4057qib7 15629 4 review review NN cord-005453-4057qib7 15629 5 screened screen VBD cord-005453-4057qib7 15629 6 all all PDT cord-005453-4057qib7 15629 7 the the DT cord-005453-4057qib7 15629 8 abstracts abstract NNS cord-005453-4057qib7 15629 9 of of IN cord-005453-4057qib7 15629 10 studies study NNS cord-005453-4057qib7 15629 11 against against IN cord-005453-4057qib7 15629 12 the the DT cord-005453-4057qib7 15629 13 inclusion inclusion NN cord-005453-4057qib7 15629 14 criteria criterion NNS cord-005453-4057qib7 15629 15 . . . cord-005453-4057qib7 15630 1 Results result NNS cord-005453-4057qib7 15630 2 : : : cord-005453-4057qib7 15630 3 Only only RB cord-005453-4057qib7 15630 4 nine nine CD cord-005453-4057qib7 15630 5 papers paper NNS cord-005453-4057qib7 15630 6 published publish VBN cord-005453-4057qib7 15630 7 between between IN cord-005453-4057qib7 15630 8 2006 2006 CD cord-005453-4057qib7 15630 9 and and CC cord-005453-4057qib7 15630 10 2016 2016 CD cord-005453-4057qib7 15630 11 , , , cord-005453-4057qib7 15630 12 with with IN cord-005453-4057qib7 15630 13 information information NN cord-005453-4057qib7 15630 14 on on IN cord-005453-4057qib7 15630 15 late late JJ cord-005453-4057qib7 15630 16 effects effect NNS cord-005453-4057qib7 15630 17 in in IN cord-005453-4057qib7 15630 18 HLH HLH NNP cord-005453-4057qib7 15630 19 patients patient NNS cord-005453-4057qib7 15630 20 who who WP cord-005453-4057qib7 15630 21 had have VBD cord-005453-4057qib7 15630 22 undergone undergo VBN cord-005453-4057qib7 15630 23 HSCT HSCT NNP cord-005453-4057qib7 15630 24 , , , cord-005453-4057qib7 15630 25 were be VBD cord-005453-4057qib7 15630 26 identified identify VBN cord-005453-4057qib7 15630 27 . . . cord-005453-4057qib7 15631 1 Three three CD cord-005453-4057qib7 15631 2 reports report NNS cord-005453-4057qib7 15631 3 include include VBP cord-005453-4057qib7 15631 4 only only RB cord-005453-4057qib7 15631 5 small small JJ cord-005453-4057qib7 15631 6 numbers number NNS cord-005453-4057qib7 15631 7 of of IN cord-005453-4057qib7 15631 8 HLH HLH NNP cord-005453-4057qib7 15631 9 patients patient NNS cord-005453-4057qib7 15631 10 . . . cord-005453-4057qib7 15632 1 The the DT cord-005453-4057qib7 15632 2 remaining remain VBG cord-005453-4057qib7 15632 3 6 6 CD cord-005453-4057qib7 15632 4 papers paper NNS cord-005453-4057qib7 15632 5 contain contain VBP cord-005453-4057qib7 15632 6 data datum NNS cord-005453-4057qib7 15632 7 on on IN cord-005453-4057qib7 15632 8 261 261 CD cord-005453-4057qib7 15632 9 long long JJ cord-005453-4057qib7 15632 10 - - HYPH cord-005453-4057qib7 15632 11 term term NN cord-005453-4057qib7 15632 12 survivors survivor NNS cord-005453-4057qib7 15632 13 with with IN cord-005453-4057qib7 15632 14 a a DT cord-005453-4057qib7 15632 15 median median JJ cord-005453-4057qib7 15632 16 follow follow NN cord-005453-4057qib7 15632 17 - - HYPH cord-005453-4057qib7 15632 18 up up NN cord-005453-4057qib7 15632 19 of of IN cord-005453-4057qib7 15632 20 5.4 5.4 CD cord-005453-4057qib7 15632 21 years year NNS cord-005453-4057qib7 15632 22 . . . cord-005453-4057qib7 15633 1 Five five CD cord-005453-4057qib7 15633 2 papers paper NNS cord-005453-4057qib7 15633 3 address address VBP cord-005453-4057qib7 15633 4 neurological neurological JJ cord-005453-4057qib7 15633 5 sequelae sequela NNS cord-005453-4057qib7 15633 6 with with IN cord-005453-4057qib7 15633 7 a a DT cord-005453-4057qib7 15633 8 reported report VBN cord-005453-4057qib7 15633 9 incidence incidence NN cord-005453-4057qib7 15633 10 from from IN cord-005453-4057qib7 15633 11 7 7 CD cord-005453-4057qib7 15633 12 - - SYM cord-005453-4057qib7 15633 13 57 57 CD cord-005453-4057qib7 15633 14 % % NN cord-005453-4057qib7 15633 15 . . . cord-005453-4057qib7 15634 1 The the DT cord-005453-4057qib7 15634 2 highest high JJS cord-005453-4057qib7 15634 3 incidence incidence NN cord-005453-4057qib7 15634 4 was be VBD cord-005453-4057qib7 15634 5 found find VBN cord-005453-4057qib7 15634 6 after after IN cord-005453-4057qib7 15634 7 a a DT cord-005453-4057qib7 15634 8 thorough thorough JJ cord-005453-4057qib7 15634 9 neurological neurological JJ cord-005453-4057qib7 15634 10 assessment assessment NN cord-005453-4057qib7 15634 11 of of IN cord-005453-4057qib7 15634 12 21 21 CD cord-005453-4057qib7 15634 13 HLH HLH NNP cord-005453-4057qib7 15634 14 patients patient NNS cord-005453-4057qib7 15634 15 compared compare VBN cord-005453-4057qib7 15634 16 to to IN cord-005453-4057qib7 15634 17 matched match VBN cord-005453-4057qib7 15634 18 sibling sibling NN cord-005453-4057qib7 15634 19 controls control NNS cord-005453-4057qib7 15634 20 . . . cord-005453-4057qib7 15635 1 However however RB cord-005453-4057qib7 15635 2 , , , cord-005453-4057qib7 15635 3 the the DT cord-005453-4057qib7 15635 4 association association NN cord-005453-4057qib7 15635 5 with with IN cord-005453-4057qib7 15635 6 CNS CNS NNP cord-005453-4057qib7 15635 7 disease disease NN cord-005453-4057qib7 15635 8 before before IN cord-005453-4057qib7 15635 9 transplant transplant NN cord-005453-4057qib7 15635 10 and and CC cord-005453-4057qib7 15635 11 age age NN cord-005453-4057qib7 15635 12 at at IN cord-005453-4057qib7 15635 13 transplant transplant NN cord-005453-4057qib7 15635 14 was be VBD cord-005453-4057qib7 15635 15 not not RB cord-005453-4057qib7 15635 16 clear clear JJ cord-005453-4057qib7 15635 17 . . . cord-005453-4057qib7 15636 1 Patients patient NNS cord-005453-4057qib7 15636 2 with with IN cord-005453-4057qib7 15636 3 EBVassociated ebvassociate VBN cord-005453-4057qib7 15636 4 HLH HLH NNP cord-005453-4057qib7 15636 5 seem seem VBP cord-005453-4057qib7 15636 6 to to TO cord-005453-4057qib7 15636 7 have have VB cord-005453-4057qib7 15636 8 fewer few JJR cord-005453-4057qib7 15636 9 long long JJ cord-005453-4057qib7 15636 10 - - HYPH cord-005453-4057qib7 15636 11 term term NN cord-005453-4057qib7 15636 12 neurological neurological JJ cord-005453-4057qib7 15636 13 problems problem NNS cord-005453-4057qib7 15636 14 . . . cord-005453-4057qib7 15637 1 Non non JJ cord-005453-4057qib7 15637 2 - - JJ cord-005453-4057qib7 15637 3 neurological neurological JJ cord-005453-4057qib7 15637 4 late late JJ cord-005453-4057qib7 15637 5 effects effect NNS cord-005453-4057qib7 15637 6 are be VBP cord-005453-4057qib7 15637 7 described describe VBN cord-005453-4057qib7 15637 8 in in IN cord-005453-4057qib7 15637 9 4 4 CD cord-005453-4057qib7 15637 10 papers paper NNS cord-005453-4057qib7 15637 11 only only RB cord-005453-4057qib7 15637 12 , , , cord-005453-4057qib7 15637 13 with with IN cord-005453-4057qib7 15637 14 endocrinological endocrinological JJ cord-005453-4057qib7 15637 15 problems problem NNS cord-005453-4057qib7 15637 16 , , , cord-005453-4057qib7 15637 17 namely namely RB cord-005453-4057qib7 15637 18 short short JJ cord-005453-4057qib7 15637 19 stature stature NN cord-005453-4057qib7 15637 20 , , , cord-005453-4057qib7 15637 21 being be VBG cord-005453-4057qib7 15637 22 the the DT cord-005453-4057qib7 15637 23 most most RBS cord-005453-4057qib7 15637 24 frequent frequent JJ cord-005453-4057qib7 15637 25 . . . cord-005453-4057qib7 15638 1 One one CD cord-005453-4057qib7 15638 2 paper paper NN cord-005453-4057qib7 15638 3 specifically specifically RB cord-005453-4057qib7 15638 4 analyzed analyze VBD cord-005453-4057qib7 15638 5 poor poor JJ cord-005453-4057qib7 15638 6 growth growth NN cord-005453-4057qib7 15638 7 , , , cord-005453-4057qib7 15638 8 thyroid thyroid NN cord-005453-4057qib7 15638 9 dysfunction dysfunction NN cord-005453-4057qib7 15638 10 and and CC cord-005453-4057qib7 15638 11 vitamin vitamin NN cord-005453-4057qib7 15638 12 D d NN cord-005453-4057qib7 15638 13 deficiency deficiency NN cord-005453-4057qib7 15638 14 in in IN cord-005453-4057qib7 15638 15 a a DT cord-005453-4057qib7 15638 16 cohort cohort NN cord-005453-4057qib7 15638 17 of of IN cord-005453-4057qib7 15638 18 patients patient NNS cord-005453-4057qib7 15638 19 with with IN cord-005453-4057qib7 15638 20 non non JJ cord-005453-4057qib7 15638 21 - - JJ cord-005453-4057qib7 15638 22 malignant malignant JJ cord-005453-4057qib7 15638 23 disorders disorder NNS cord-005453-4057qib7 15638 24 including include VBG cord-005453-4057qib7 15638 25 HLH HLH NNP cord-005453-4057qib7 15638 26 who who WP cord-005453-4057qib7 15638 27 had have VBD cord-005453-4057qib7 15638 28 undergone undergo VBN cord-005453-4057qib7 15638 29 HSCT HSCT NNP cord-005453-4057qib7 15638 30 after after IN cord-005453-4057qib7 15638 31 a a DT cord-005453-4057qib7 15638 32 reduced reduce VBN cord-005453-4057qib7 15638 33 intensity intensity NN cord-005453-4057qib7 15638 34 conditioning conditioning NN cord-005453-4057qib7 15638 35 regimen regimen NN cord-005453-4057qib7 15638 36 and and CC cord-005453-4057qib7 15638 37 found find VBD cord-005453-4057qib7 15638 38 significant significant JJ cord-005453-4057qib7 15638 39 abnormalities abnormality NNS cord-005453-4057qib7 15638 40 in in IN cord-005453-4057qib7 15638 41 all all DT cord-005453-4057qib7 15638 42 groups group NNS cord-005453-4057qib7 15638 43 . . . cord-005453-4057qib7 15639 1 Conclusions conclusion NNS cord-005453-4057qib7 15639 2 : : : cord-005453-4057qib7 15640 1 Data datum NNS cord-005453-4057qib7 15640 2 on on IN cord-005453-4057qib7 15640 3 late late JJ cord-005453-4057qib7 15640 4 effects effect NNS cord-005453-4057qib7 15640 5 in in IN cord-005453-4057qib7 15640 6 HLH HLH NNP cord-005453-4057qib7 15640 7 patients patient NNS cord-005453-4057qib7 15640 8 is be VBZ cord-005453-4057qib7 15640 9 scarce scarce JJ cord-005453-4057qib7 15640 10 and and CC cord-005453-4057qib7 15640 11 is be VBZ cord-005453-4057qib7 15640 12 mostly mostly RB cord-005453-4057qib7 15640 13 based base VBN cord-005453-4057qib7 15640 14 on on IN cord-005453-4057qib7 15640 15 the the DT cord-005453-4057qib7 15640 16 retrospective retrospective JJ cord-005453-4057qib7 15640 17 evaluation evaluation NN cord-005453-4057qib7 15640 18 of of IN cord-005453-4057qib7 15640 19 small small JJ cord-005453-4057qib7 15640 20 national national JJ cord-005453-4057qib7 15640 21 cohorts cohort NNS cord-005453-4057qib7 15640 22 . . . cord-005453-4057qib7 15641 1 The the DT cord-005453-4057qib7 15641 2 available available JJ cord-005453-4057qib7 15641 3 information information NN cord-005453-4057qib7 15641 4 indicates indicate VBZ cord-005453-4057qib7 15641 5 that that IN cord-005453-4057qib7 15641 6 a a DT cord-005453-4057qib7 15641 7 significant significant JJ cord-005453-4057qib7 15641 8 number number NN cord-005453-4057qib7 15641 9 of of IN cord-005453-4057qib7 15641 10 patients patient NNS cord-005453-4057qib7 15641 11 suffers suffer VBZ cord-005453-4057qib7 15641 12 from from IN cord-005453-4057qib7 15641 13 problems problem NNS cord-005453-4057qib7 15641 14 which which WDT cord-005453-4057qib7 15641 15 affect affect VBP cord-005453-4057qib7 15641 16 their -PRON- PRP$ cord-005453-4057qib7 15641 17 daily daily JJ cord-005453-4057qib7 15641 18 life life NN cord-005453-4057qib7 15641 19 , , , cord-005453-4057qib7 15641 20 but but CC cord-005453-4057qib7 15641 21 lack lack NN cord-005453-4057qib7 15641 22 of of IN cord-005453-4057qib7 15641 23 information information NN cord-005453-4057qib7 15641 24 does do VBZ cord-005453-4057qib7 15641 25 not not RB cord-005453-4057qib7 15641 26 allow allow VB cord-005453-4057qib7 15641 27 to to TO cord-005453-4057qib7 15641 28 analyze analyze VB cord-005453-4057qib7 15641 29 the the DT cord-005453-4057qib7 15641 30 association association NN cord-005453-4057qib7 15641 31 between between IN cord-005453-4057qib7 15641 32 pre pre JJ cord-005453-4057qib7 15641 33 - - JJ cord-005453-4057qib7 15641 34 transplant transplant JJ cord-005453-4057qib7 15641 35 conditions condition NNS cord-005453-4057qib7 15641 36 and and CC cord-005453-4057qib7 15641 37 long long JJ cord-005453-4057qib7 15641 38 - - HYPH cord-005453-4057qib7 15641 39 term term NN cord-005453-4057qib7 15641 40 sequelae sequela NNS cord-005453-4057qib7 15641 41 . . . cord-005453-4057qib7 15642 1 Therefore therefore RB cord-005453-4057qib7 15642 2 , , , cord-005453-4057qib7 15642 3 a a DT cord-005453-4057qib7 15642 4 retrospective retrospective JJ cord-005453-4057qib7 15642 5 comprehensive comprehensive JJ cord-005453-4057qib7 15642 6 analysis analysis NN cord-005453-4057qib7 15642 7 of of IN cord-005453-4057qib7 15642 8 patients patient NNS cord-005453-4057qib7 15642 9 registered register VBN cord-005453-4057qib7 15642 10 in in IN cord-005453-4057qib7 15642 11 the the DT cord-005453-4057qib7 15642 12 EBMT EBMT NNP cord-005453-4057qib7 15642 13 and and CC cord-005453-4057qib7 15642 14 CIBMTR CIBMTR NNP cord-005453-4057qib7 15642 15 registries registry NNS cord-005453-4057qib7 15642 16 is be VBZ cord-005453-4057qib7 15642 17 currently currently RB cord-005453-4057qib7 15642 18 performed perform VBN cord-005453-4057qib7 15642 19 . . . cord-005453-4057qib7 15643 1 It -PRON- PRP cord-005453-4057qib7 15643 2 will will MD cord-005453-4057qib7 15643 3 be be VB cord-005453-4057qib7 15643 4 crucial crucial JJ cord-005453-4057qib7 15643 5 to to TO cord-005453-4057qib7 15643 6 better better RB cord-005453-4057qib7 15643 7 define define VB cord-005453-4057qib7 15643 8 the the DT cord-005453-4057qib7 15643 9 frequency frequency NN cord-005453-4057qib7 15643 10 and and CC cord-005453-4057qib7 15643 11 type type NN cord-005453-4057qib7 15643 12 of of IN cord-005453-4057qib7 15643 13 late late JJ cord-005453-4057qib7 15643 14 effects effect NNS cord-005453-4057qib7 15643 15 in in IN cord-005453-4057qib7 15643 16 a a DT cord-005453-4057qib7 15643 17 large large JJ cord-005453-4057qib7 15643 18 cohort cohort NN cord-005453-4057qib7 15643 19 . . . cord-005453-4057qib7 15644 1 This this DT cord-005453-4057qib7 15644 2 knowledge knowledge NN cord-005453-4057qib7 15644 3 will will MD cord-005453-4057qib7 15644 4 aid aid VB cord-005453-4057qib7 15644 5 counselling counselling NN cord-005453-4057qib7 15644 6 prior prior RB cord-005453-4057qib7 15644 7 to to IN cord-005453-4057qib7 15644 8 HSCT HSCT NNP cord-005453-4057qib7 15644 9 , , , cord-005453-4057qib7 15644 10 provide provide VB cord-005453-4057qib7 15644 11 guidance guidance NN cord-005453-4057qib7 15644 12 for for IN cord-005453-4057qib7 15644 13 long long JJ cord-005453-4057qib7 15644 14 - - HYPH cord-005453-4057qib7 15644 15 term term NN cord-005453-4057qib7 15644 16 monitoring monitoring NN cord-005453-4057qib7 15644 17 of of IN cord-005453-4057qib7 15644 18 these these DT cord-005453-4057qib7 15644 19 patients patient NNS cord-005453-4057qib7 15644 20 , , , cord-005453-4057qib7 15644 21 and and CC cord-005453-4057qib7 15644 22 potentially potentially RB cord-005453-4057qib7 15644 23 identify identify VB cord-005453-4057qib7 15644 24 specific specific JJ cord-005453-4057qib7 15644 25 risk risk NN cord-005453-4057qib7 15644 26 factors factor NNS cord-005453-4057qib7 15644 27 for for IN cord-005453-4057qib7 15644 28 late late JJ cord-005453-4057qib7 15644 29 effects effect NNS cord-005453-4057qib7 15644 30 in in IN cord-005453-4057qib7 15644 31 this this DT cord-005453-4057qib7 15644 32 rare rare JJ cord-005453-4057qib7 15644 33 patient patient NN cord-005453-4057qib7 15644 34 population population NN cord-005453-4057qib7 15644 35 . . . cord-005453-4057qib7 15645 1 Disclosure disclosure NN cord-005453-4057qib7 15645 2 : : : cord-005453-4057qib7 15645 3 Nothing nothing NN cord-005453-4057qib7 15645 4 to to TO cord-005453-4057qib7 15645 5 declare declare VB cord-005453-4057qib7 15645 6 . . . cord-005453-4057qib7 15646 1 Allogeneic allogeneic IN cord-005453-4057qib7 15646 2 stem stem VBP cord-005453-4057qib7 15646 3 cell cell NN cord-005453-4057qib7 15646 4 transplantation transplantation NN cord-005453-4057qib7 15646 5 in in IN cord-005453-4057qib7 15646 6 patients patient NNS cord-005453-4057qib7 15646 7 with with IN cord-005453-4057qib7 15646 8 mucopolysaccharidosis mucopolysaccharidosis NNP cord-005453-4057qib7 15646 9 type type NN cord-005453-4057qib7 15646 10 II II NNP cord-005453-4057qib7 15646 11 ( ( -LRB- cord-005453-4057qib7 15646 12 Morbus Morbus NNP cord-005453-4057qib7 15646 13 hunter)Bernd hunter)bernd JJ cord-005453-4057qib7 15646 14 Hartz Hartz NNP cord-005453-4057qib7 15646 15 1 1 CD cord-005453-4057qib7 15646 16 , , , cord-005453-4057qib7 15646 17 Nicole Nicole NNP cord-005453-4057qib7 15646 18 Muschol Muschol NNP cord-005453-4057qib7 15646 19 2 2 CD cord-005453-4057qib7 15646 20 , , , cord-005453-4057qib7 15646 21 Matthias Matthias NNP cord-005453-4057qib7 15646 22 Bleeke Bleeke NNP cord-005453-4057qib7 15646 23 1 1 CD cord-005453-4057qib7 15646 24 , , , cord-005453-4057qib7 15646 25 Johanna Johanna NNP cord-005453-4057qib7 15646 26 Schrum Schrum NNP cord-005453-4057qib7 15646 27 1 1 CD cord-005453-4057qib7 15646 28 , , , cord-005453-4057qib7 15646 29 Ingo Ingo NNP cord-005453-4057qib7 15646 30 Müller Müller NNP cord-005453-4057qib7 15647 1 1Background 1background LS cord-005453-4057qib7 15647 2 : : : cord-005453-4057qib7 15647 3 The the DT cord-005453-4057qib7 15647 4 transplantation transplantation NN cord-005453-4057qib7 15647 5 of of IN cord-005453-4057qib7 15647 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 15647 7 stem stem NN cord-005453-4057qib7 15647 8 cells cell NNS cord-005453-4057qib7 15647 9 ( ( -LRB- cord-005453-4057qib7 15647 10 HSCT HSCT NNP cord-005453-4057qib7 15647 11 ) ) -RRB- cord-005453-4057qib7 15647 12 is be VBZ cord-005453-4057qib7 15647 13 one one CD cord-005453-4057qib7 15647 14 of of IN cord-005453-4057qib7 15647 15 the the DT cord-005453-4057qib7 15647 16 leading lead VBG cord-005453-4057qib7 15647 17 methods method NNS cord-005453-4057qib7 15647 18 of of IN cord-005453-4057qib7 15647 19 treatment treatment NN cord-005453-4057qib7 15647 20 in in IN cord-005453-4057qib7 15647 21 patients patient NNS cord-005453-4057qib7 15647 22 with with IN cord-005453-4057qib7 15647 23 blood blood NN cord-005453-4057qib7 15647 24 system system NN cord-005453-4057qib7 15647 25 diseases disease NNS cord-005453-4057qib7 15647 26 , , , cord-005453-4057qib7 15647 27 primary primary JJ cord-005453-4057qib7 15647 28 immunodeficiency immunodeficiency NN cord-005453-4057qib7 15647 29 syndromes syndrome NNS cord-005453-4057qib7 15647 30 and and CC cord-005453-4057qib7 15647 31 genetic genetic JJ cord-005453-4057qib7 15647 32 diseases disease NNS cord-005453-4057qib7 15647 33 . . . cord-005453-4057qib7 15648 1 At at IN cord-005453-4057qib7 15648 2 the the DT cord-005453-4057qib7 15648 3 same same JJ cord-005453-4057qib7 15648 4 time time NN cord-005453-4057qib7 15648 5 , , , cord-005453-4057qib7 15648 6 the the DT cord-005453-4057qib7 15648 7 quality quality NN cord-005453-4057qib7 15648 8 of of IN cord-005453-4057qib7 15648 9 life life NN cord-005453-4057qib7 15648 10 in in IN cord-005453-4057qib7 15648 11 patients patient NNS cord-005453-4057qib7 15648 12 in in IN cord-005453-4057qib7 15648 13 the the DT cord-005453-4057qib7 15648 14 long long JJ cord-005453-4057qib7 15648 15 - - HYPH cord-005453-4057qib7 15648 16 term term NN cord-005453-4057qib7 15648 17 after after IN cord-005453-4057qib7 15648 18 HSCT HSCT NNP cord-005453-4057qib7 15648 19 significantly significantly RB cord-005453-4057qib7 15648 20 differs differ VBZ cord-005453-4057qib7 15648 21 from from IN cord-005453-4057qib7 15648 22 the the DT cord-005453-4057qib7 15648 23 quality quality NN cord-005453-4057qib7 15648 24 of of IN cord-005453-4057qib7 15648 25 life life NN cord-005453-4057qib7 15648 26 of of IN cord-005453-4057qib7 15648 27 healthy healthy JJ cord-005453-4057qib7 15648 28 people people NNS cord-005453-4057qib7 15648 29 of of IN cord-005453-4057qib7 15648 30 the the DT cord-005453-4057qib7 15648 31 same same JJ cord-005453-4057qib7 15648 32 age age NN cord-005453-4057qib7 15648 33 . . . cord-005453-4057qib7 15649 1 Deformations deformation NNS cord-005453-4057qib7 15649 2 in in IN cord-005453-4057qib7 15649 3 psychosexual psychosexual JJ cord-005453-4057qib7 15649 4 development development NN cord-005453-4057qib7 15649 5 including include VBG cord-005453-4057qib7 15649 6 problems problem NNS cord-005453-4057qib7 15649 7 in in IN cord-005453-4057qib7 15649 8 the the DT cord-005453-4057qib7 15649 9 gender gender NN cord-005453-4057qib7 15649 10 identity identity NN cord-005453-4057qib7 15649 11 formation formation NN cord-005453-4057qib7 15649 12 cause cause VBP cord-005453-4057qib7 15649 13 social social JJ cord-005453-4057qib7 15649 14 isolation isolation NN cord-005453-4057qib7 15649 15 of of IN cord-005453-4057qib7 15649 16 adolescents adolescent NNS cord-005453-4057qib7 15649 17 , , , cord-005453-4057qib7 15649 18 which which WDT cord-005453-4057qib7 15649 19 makes make VBZ cord-005453-4057qib7 15649 20 their -PRON- PRP$ cord-005453-4057qib7 15649 21 sexual sexual JJ cord-005453-4057qib7 15649 22 selfrealization selfrealization NN cord-005453-4057qib7 15649 23 impossible impossible JJ cord-005453-4057qib7 15649 24 and and CC cord-005453-4057qib7 15649 25 significantly significantly RB cord-005453-4057qib7 15649 26 reduces reduce VBZ cord-005453-4057qib7 15649 27 the the DT cord-005453-4057qib7 15649 28 quality quality NN cord-005453-4057qib7 15649 29 of of IN cord-005453-4057qib7 15649 30 their -PRON- PRP$ cord-005453-4057qib7 15649 31 life life NN cord-005453-4057qib7 15649 32 . . . cord-005453-4057qib7 15650 1 The the DT cord-005453-4057qib7 15650 2 purpose purpose NN cord-005453-4057qib7 15650 3 of of IN cord-005453-4057qib7 15650 4 our -PRON- PRP$ cord-005453-4057qib7 15650 5 study study NN cord-005453-4057qib7 15650 6 was be VBD cord-005453-4057qib7 15650 7 an an DT cord-005453-4057qib7 15650 8 assessment assessment NN cord-005453-4057qib7 15650 9 of of IN cord-005453-4057qib7 15650 10 the the DT cord-005453-4057qib7 15650 11 level level NN cord-005453-4057qib7 15650 12 of of IN cord-005453-4057qib7 15650 13 gender gender NN cord-005453-4057qib7 15650 14 identity identity NN cord-005453-4057qib7 15650 15 formation formation NN cord-005453-4057qib7 15650 16 of of IN cord-005453-4057qib7 15650 17 adolescents adolescent NNS cord-005453-4057qib7 15650 18 and and CC cord-005453-4057qib7 15650 19 psychosexual psychosexual JJ cord-005453-4057qib7 15650 20 development development NN cord-005453-4057qib7 15650 21 correlation correlation NN cord-005453-4057qib7 15650 22 to to IN cord-005453-4057qib7 15650 23 the the DT cord-005453-4057qib7 15650 24 normal normal JJ cord-005453-4057qib7 15650 25 adolescents adolescent NNS cord-005453-4057qib7 15650 26 of of IN cord-005453-4057qib7 15650 27 the the DT cord-005453-4057qib7 15650 28 same same JJ cord-005453-4057qib7 15650 29 age age NN cord-005453-4057qib7 15650 30 . . . cord-005453-4057qib7 15651 1 Methods method NNS cord-005453-4057qib7 15651 2 : : : cord-005453-4057qib7 15651 3 In in IN cord-005453-4057qib7 15651 4 a a DT cord-005453-4057qib7 15651 5 prospective prospective JJ cord-005453-4057qib7 15651 6 single single JJ cord-005453-4057qib7 15651 7 - - HYPH cord-005453-4057qib7 15651 8 center center NN cord-005453-4057qib7 15651 9 study study NN cord-005453-4057qib7 15651 10 in in IN cord-005453-4057qib7 15651 11 2018 2018 CD cord-005453-4057qib7 15651 12 , , , cord-005453-4057qib7 15651 13 on on IN cord-005453-4057qib7 15651 14 the the DT cord-005453-4057qib7 15651 15 base base NN cord-005453-4057qib7 15651 16 of of IN cord-005453-4057qib7 15651 17 the the DT cord-005453-4057qib7 15651 18 Department Department NNP cord-005453-4057qib7 15651 19 of of IN cord-005453-4057qib7 15651 20 Rehabilitation Rehabilitation NNP cord-005453-4057qib7 15651 21 Medicine Medicine NNP cord-005453-4057qib7 15651 22 Raisa Raisa NNP cord-005453-4057qib7 15651 23 Gorbacheva Gorbacheva NNP cord-005453-4057qib7 15651 24 Memorial Memorial NNP cord-005453-4057qib7 15651 25 Institute Institute NNP cord-005453-4057qib7 15651 26 of of IN cord-005453-4057qib7 15651 27 Children´s Children´s NNP cord-005453-4057qib7 15651 28 Oncology Oncology NNP cord-005453-4057qib7 15651 29 , , , cord-005453-4057qib7 15651 30 Hematology Hematology NNP cord-005453-4057qib7 15651 31 and and CC cord-005453-4057qib7 15651 32 Transplantation Transplantation NNP cord-005453-4057qib7 15651 33 , , , cord-005453-4057qib7 15651 34 we -PRON- PRP cord-005453-4057qib7 15651 35 conducted conduct VBD cord-005453-4057qib7 15651 36 a a DT cord-005453-4057qib7 15651 37 study study NN cord-005453-4057qib7 15651 38 of of IN cord-005453-4057qib7 15651 39 17 17 CD cord-005453-4057qib7 15651 40 families family NNS cord-005453-4057qib7 15651 41 . . . cord-005453-4057qib7 15652 1 The the DT cord-005453-4057qib7 15652 2 respondents respondent NNS cord-005453-4057qib7 15652 3 were be VBD cord-005453-4057qib7 15652 4 : : : cord-005453-4057qib7 15652 5 1 1 LS cord-005453-4057qib7 15652 6 ) ) -RRB- cord-005453-4057qib7 15652 7 parents parent NNS cord-005453-4057qib7 15652 8 / / SYM cord-005453-4057qib7 15652 9 guardians guardian NNS cord-005453-4057qib7 15652 10 of of IN cord-005453-4057qib7 15652 11 patients patient NNS cord-005453-4057qib7 15652 12 accompanying accompany VBG cord-005453-4057qib7 15652 13 them -PRON- PRP cord-005453-4057qib7 15652 14 in in IN cord-005453-4057qib7 15652 15 the the DT cord-005453-4057qib7 15652 16 process process NN cord-005453-4057qib7 15652 17 of of IN cord-005453-4057qib7 15652 18 examination examination NN cord-005453-4057qib7 15652 19 ; ; : cord-005453-4057qib7 15652 20 2 2 LS cord-005453-4057qib7 15652 21 ) ) -RRB- cord-005453-4057qib7 15652 22 adolescents adolescent NNS cord-005453-4057qib7 15652 23 who who WP cord-005453-4057qib7 15652 24 underwent undergo VBD cord-005453-4057qib7 15652 25 HSCT HSCT NNP cord-005453-4057qib7 15652 26 treatment treatment NN cord-005453-4057qib7 15652 27 and and CC cord-005453-4057qib7 15652 28 undergo undergo VB cord-005453-4057qib7 15652 29 planned planned JJ cord-005453-4057qib7 15652 30 examinations examination NNS cord-005453-4057qib7 15652 31 at at IN cord-005453-4057qib7 15652 32 the the DT cord-005453-4057qib7 15652 33 clinic clinic NN cord-005453-4057qib7 15652 34 in in IN cord-005453-4057qib7 15652 35 the the DT cord-005453-4057qib7 15652 36 posttransplant posttransplant NN cord-005453-4057qib7 15652 37 period period NN cord-005453-4057qib7 15652 38 ( ( -LRB- cord-005453-4057qib7 15652 39 after after IN cord-005453-4057qib7 15652 40 D D NNP cord-005453-4057qib7 15652 41 + + CC cord-005453-4057qib7 15652 42 100 100 CD cord-005453-4057qib7 15652 43 ) ) -RRB- cord-005453-4057qib7 15652 44 , , , cord-005453-4057qib7 15652 45 ( ( -LRB- cord-005453-4057qib7 15652 46 n n NN cord-005453-4057qib7 15652 47 = = SYM cord-005453-4057qib7 15652 48 17 17 CD cord-005453-4057qib7 15652 49 , , , cord-005453-4057qib7 15652 50 of of IN cord-005453-4057qib7 15652 51 which which WDT cord-005453-4057qib7 15652 52 8 8 CD cord-005453-4057qib7 15652 53 girls girl NNS cord-005453-4057qib7 15652 54 and and CC cord-005453-4057qib7 15652 55 9 9 CD cord-005453-4057qib7 15652 56 boys boy NNS cord-005453-4057qib7 15652 57 , , , cord-005453-4057qib7 15652 58 age age NN cord-005453-4057qib7 15652 59 12 12 CD cord-005453-4057qib7 15652 60 -17 -17 CD cord-005453-4057qib7 15652 61 years year NNS cord-005453-4057qib7 15652 62 , , , cord-005453-4057qib7 15652 63 from from IN cord-005453-4057qib7 15652 64 the the DT cord-005453-4057qib7 15652 65 date date NN cord-005453-4057qib7 15652 66 of of IN cord-005453-4057qib7 15652 67 HSCT HSCT NNP cord-005453-4057qib7 15652 68 1 1 CD cord-005453-4057qib7 15652 69 -5 -5 NNP cord-005453-4057qib7 15653 1 years).The years).The NNP cord-005453-4057qib7 15653 2 following follow VBG cord-005453-4057qib7 15653 3 methods method NNS cord-005453-4057qib7 15653 4 were be VBD cord-005453-4057qib7 15653 5 used use VBN cord-005453-4057qib7 15653 6 to to TO cord-005453-4057qib7 15653 7 assess assess VB cord-005453-4057qib7 15653 8 gender gender NN cord-005453-4057qib7 15653 9 identity identity NN cord-005453-4057qib7 15653 10 : : : cord-005453-4057qib7 15653 11 Specially specially RB cord-005453-4057qib7 15653 12 developed develop VBN cord-005453-4057qib7 15653 13 questionnaires questionnaire NNS cord-005453-4057qib7 15653 14 for for IN cord-005453-4057qib7 15653 15 teenagers teenager NNS cord-005453-4057qib7 15653 16 and and CC cord-005453-4057qib7 15653 17 parents parent NNS cord-005453-4057qib7 15653 18 ; ; : cord-005453-4057qib7 15653 19 questionnaire questionnaire NN cord-005453-4057qib7 15653 20 by by IN cord-005453-4057qib7 15653 21 Sandra Sandra NNP cord-005453-4057qib7 15653 22 L. L. NNP cord-005453-4057qib7 15653 23 Bem Bem NNP cord-005453-4057qib7 15653 24 ( ( -LRB- cord-005453-4057qib7 15653 25 Sandra Sandra NNP cord-005453-4057qib7 15653 26 L. L. NNP cord-005453-4057qib7 15653 27 Bem Bem NNP cord-005453-4057qib7 15653 28 , , , cord-005453-4057qib7 15653 29 1974 1974 CD cord-005453-4057qib7 15653 30 ) ) -RRB- cord-005453-4057qib7 15653 31 ; ; , cord-005453-4057qib7 15653 32 projective projective JJ cord-005453-4057qib7 15653 33 techniques technique NNS cord-005453-4057qib7 15653 34 " " '' cord-005453-4057qib7 15653 35 The the DT cord-005453-4057qib7 15653 36 Human Human NNP cord-005453-4057qib7 15653 37 Picture Picture NNP cord-005453-4057qib7 15653 38 " " '' cord-005453-4057qib7 15653 39 , , , cord-005453-4057qib7 15653 40 " " `` cord-005453-4057qib7 15653 41 The the DT cord-005453-4057qib7 15653 42 non non JJ cord-005453-4057qib7 15653 43 - - JJ cord-005453-4057qib7 15653 44 existent existent JJ cord-005453-4057qib7 15653 45 animal animal NN cord-005453-4057qib7 15653 46 " " '' cord-005453-4057qib7 15653 47 ; ; : cord-005453-4057qib7 15653 48 Max Max NNP cord-005453-4057qib7 15653 49 Lüscher´s lüscher´s JJ cord-005453-4057qib7 15653 50 color color NN cord-005453-4057qib7 15653 51 choices choice NNS cord-005453-4057qib7 15653 52 test test VBP cord-005453-4057qib7 15653 53 . . . cord-005453-4057qib7 15654 1 Results result NNS cord-005453-4057qib7 15654 2 : : : cord-005453-4057qib7 15655 1 The the DT cord-005453-4057qib7 15655 2 traditional traditional JJ cord-005453-4057qib7 15655 3 type type NN cord-005453-4057qib7 15655 4 of of IN cord-005453-4057qib7 15655 5 gender gender NN cord-005453-4057qib7 15655 6 identity identity NN cord-005453-4057qib7 15655 7 , , , cord-005453-4057qib7 15655 8 which which WDT cord-005453-4057qib7 15655 9 characterizes characterize VBZ cord-005453-4057qib7 15655 10 high high JJ cord-005453-4057qib7 15655 11 masculinity masculinity NN cord-005453-4057qib7 15655 12 among among IN cord-005453-4057qib7 15655 13 male male JJ cord-005453-4057qib7 15655 14 respondents respondent NNS cord-005453-4057qib7 15655 15 and and CC cord-005453-4057qib7 15655 16 high high JJ cord-005453-4057qib7 15655 17 female female JJ cord-005453-4057qib7 15655 18 gender gender NN cord-005453-4057qib7 15655 19 indicators indicator NNS cord-005453-4057qib7 15655 20 in in IN cord-005453-4057qib7 15655 21 100 100 CD cord-005453-4057qib7 15655 22 % % NN cord-005453-4057qib7 15655 23 of of IN cord-005453-4057qib7 15655 24 cases case NNS cord-005453-4057qib7 15655 25 , , , cord-005453-4057qib7 15655 26 was be VBD cord-005453-4057qib7 15655 27 not not RB cord-005453-4057qib7 15655 28 revealed reveal VBN cord-005453-4057qib7 15655 29 . . . cord-005453-4057qib7 15656 1 Both both DT cord-005453-4057qib7 15656 2 among among IN cord-005453-4057qib7 15656 3 girls girl NNS cord-005453-4057qib7 15656 4 and and CC cord-005453-4057qib7 15656 5 among among IN cord-005453-4057qib7 15656 6 boys boy NNS cord-005453-4057qib7 15656 7 , , , cord-005453-4057qib7 15656 8 the the DT cord-005453-4057qib7 15656 9 androgynous androgynous JJ cord-005453-4057qib7 15656 10 type type NN cord-005453-4057qib7 15656 11 prevails prevail VBZ cord-005453-4057qib7 15656 12 with with IN cord-005453-4057qib7 15656 13 a a DT cord-005453-4057qib7 15656 14 tendency tendency NN cord-005453-4057qib7 15656 15 toward toward IN cord-005453-4057qib7 15656 16 femininity femininity NN cord-005453-4057qib7 15656 17 . . . cord-005453-4057qib7 15657 1 On on IN cord-005453-4057qib7 15657 2 average average JJ cord-005453-4057qib7 15657 3 , , , cord-005453-4057qib7 15657 4 adolescents adolescent NNS cord-005453-4057qib7 15657 5 see see VBP cord-005453-4057qib7 15657 6 themselves -PRON- PRP cord-005453-4057qib7 15657 7 as as IN cord-005453-4057qib7 15657 8 a a DT cord-005453-4057qib7 15657 9 bit bit NN cord-005453-4057qib7 15657 10 more more RBR cord-005453-4057qib7 15657 11 courageous courageous JJ cord-005453-4057qib7 15657 12 than than IN cord-005453-4057qib7 15657 13 their -PRON- PRP$ cord-005453-4057qib7 15657 14 mothers mother NNS cord-005453-4057qib7 15657 15 , , , cord-005453-4057qib7 15657 16 with with IN cord-005453-4057qib7 15657 17 rare rare JJ cord-005453-4057qib7 15657 18 exceptions exception NNS cord-005453-4057qib7 15657 19 , , , cord-005453-4057qib7 15657 20 regardless regardless RB cord-005453-4057qib7 15657 21 of of IN cord-005453-4057qib7 15657 22 gender gender NN cord-005453-4057qib7 15657 23 . . . cord-005453-4057qib7 15658 1 This this DT cord-005453-4057qib7 15658 2 confirms confirm VBZ cord-005453-4057qib7 15658 3 the the DT cord-005453-4057qib7 15658 4 thesis thesis NN cord-005453-4057qib7 15658 5 that that IN cord-005453-4057qib7 15658 6 we -PRON- PRP cord-005453-4057qib7 15658 7 received receive VBD cord-005453-4057qib7 15658 8 in in IN cord-005453-4057qib7 15658 9 a a DT cord-005453-4057qib7 15658 10 previous previous JJ cord-005453-4057qib7 15658 11 study study NN cord-005453-4057qib7 15658 12 that that IN cord-005453-4057qib7 15658 13 parents parent NNS cord-005453-4057qib7 15658 14 tend tend VBP cord-005453-4057qib7 15658 15 to to TO cord-005453-4057qib7 15658 16 see see VB cord-005453-4057qib7 15658 17 and and CC cord-005453-4057qib7 15658 18 encourage encourage VB cord-005453-4057qib7 15658 19 complacency complacency NN cord-005453-4057qib7 15658 20 of of IN cord-005453-4057qib7 15658 21 adolescents adolescent NNS cord-005453-4057qib7 15658 22 of of IN cord-005453-4057qib7 15658 23 both both DT cord-005453-4057qib7 15658 24 sexes sex NNS cord-005453-4057qib7 15658 25 , , , cord-005453-4057qib7 15658 26 passivity passivity NN cord-005453-4057qib7 15658 27 instead instead RB cord-005453-4057qib7 15658 28 of of IN cord-005453-4057qib7 15658 29 leadership leadership NN cord-005453-4057qib7 15658 30 , , , cord-005453-4057qib7 15658 31 dedication dedication NN cord-005453-4057qib7 15658 32 and and CC cord-005453-4057qib7 15658 33 independence independence NN cord-005453-4057qib7 15658 34 . . . cord-005453-4057qib7 15659 1 All all DT cord-005453-4057qib7 15659 2 100 100 CD cord-005453-4057qib7 15659 3 % % NN cord-005453-4057qib7 15659 4 of of IN cord-005453-4057qib7 15659 5 adolescents adolescent NNS cord-005453-4057qib7 15659 6 who who WP cord-005453-4057qib7 15659 7 participated participate VBD cord-005453-4057qib7 15659 8 in in IN cord-005453-4057qib7 15659 9 the the DT cord-005453-4057qib7 15659 10 test test NN cord-005453-4057qib7 15659 11 demonstrate demonstrate VBP cord-005453-4057qib7 15659 12 a a DT cord-005453-4057qib7 15659 13 shift shift NN cord-005453-4057qib7 15659 14 in in IN cord-005453-4057qib7 15659 15 the the DT cord-005453-4057qib7 15659 16 theme theme NN cord-005453-4057qib7 15659 17 of of IN cord-005453-4057qib7 15659 18 aggression aggression NN cord-005453-4057qib7 15659 19 , , , cord-005453-4057qib7 15659 20 77 77 CD cord-005453-4057qib7 15659 21 % % NN cord-005453-4057qib7 15659 22 have have VBP cord-005453-4057qib7 15659 23 some some DT cord-005453-4057qib7 15659 24 signs sign NNS cord-005453-4057qib7 15659 25 of of IN cord-005453-4057qib7 15659 26 preventing prevent VBG cord-005453-4057qib7 15659 27 sexual sexual JJ cord-005453-4057qib7 15659 28 self self NN cord-005453-4057qib7 15659 29 - - HYPH cord-005453-4057qib7 15659 30 determination determination NN cord-005453-4057qib7 15659 31 , , , cord-005453-4057qib7 15659 32 abandoning abandon VBG cord-005453-4057qib7 15659 33 their -PRON- PRP$ cord-005453-4057qib7 15659 34 body body NN cord-005453-4057qib7 15659 35 , , , cord-005453-4057qib7 15659 36 gender gender NN cord-005453-4057qib7 15659 37 , , , cord-005453-4057qib7 15659 38 and and CC cord-005453-4057qib7 15659 39 age age NN cord-005453-4057qib7 15659 40 . . . cord-005453-4057qib7 15660 1 88 88 CD cord-005453-4057qib7 15660 2 % % NN cord-005453-4057qib7 15660 3 of of IN cord-005453-4057qib7 15660 4 patients patient NNS cord-005453-4057qib7 15660 5 do do VBP cord-005453-4057qib7 15660 6 not not RB cord-005453-4057qib7 15660 7 communicate communicate VB cord-005453-4057qib7 15660 8 with with IN cord-005453-4057qib7 15660 9 their -PRON- PRP$ cord-005453-4057qib7 15660 10 peers peer NNS cord-005453-4057qib7 15660 11 . . . cord-005453-4057qib7 15661 1 In in IN cord-005453-4057qib7 15661 2 47 47 CD cord-005453-4057qib7 15661 3 % % NN cord-005453-4057qib7 15661 4 of of IN cord-005453-4057qib7 15661 5 them -PRON- PRP cord-005453-4057qib7 15661 6 , , , cord-005453-4057qib7 15661 7 negative negative JJ cord-005453-4057qib7 15661 8 emotions emotion NNS cord-005453-4057qib7 15661 9 prevail prevail VBP cord-005453-4057qib7 15661 10 over over IN cord-005453-4057qib7 15661 11 positive positive JJ cord-005453-4057qib7 15661 12 ones one NNS cord-005453-4057qib7 15661 13 . . . cord-005453-4057qib7 15662 1 One one CD cord-005453-4057qib7 15662 2 third third NN cord-005453-4057qib7 15662 3 of of IN cord-005453-4057qib7 15662 4 the the DT cord-005453-4057qib7 15662 5 test test NN cord-005453-4057qib7 15662 6 participants participant NNS cord-005453-4057qib7 15662 7 demonstrate demonstrate VBP cord-005453-4057qib7 15662 8 strong strong JJ cord-005453-4057qib7 15662 9 support support NN cord-005453-4057qib7 15662 10 for for IN cord-005453-4057qib7 15662 11 rest rest NN cord-005453-4057qib7 15662 12 and and CC cord-005453-4057qib7 15662 13 minimizing minimize VBG cord-005453-4057qib7 15662 14 their -PRON- PRP$ cord-005453-4057qib7 15662 15 efforts effort NNS cord-005453-4057qib7 15662 16 . . . cord-005453-4057qib7 15663 1 Conclusions conclusion NNS cord-005453-4057qib7 15663 2 : : : cord-005453-4057qib7 15664 1 The the DT cord-005453-4057qib7 15664 2 characteristics characteristic NNS cord-005453-4057qib7 15664 3 of of IN cord-005453-4057qib7 15664 4 family family NN cord-005453-4057qib7 15664 5 upbringing upbringing NN cord-005453-4057qib7 15664 6 of of IN cord-005453-4057qib7 15664 7 adolescents adolescent NNS cord-005453-4057qib7 15664 8 who who WP cord-005453-4057qib7 15664 9 have have VBP cord-005453-4057qib7 15664 10 undergone undergo VBN cord-005453-4057qib7 15664 11 HSCT HSCT NNP cord-005453-4057qib7 15664 12 often often RB cord-005453-4057qib7 15664 13 contribute contribute VBP cord-005453-4057qib7 15664 14 significantly significantly RB cord-005453-4057qib7 15664 15 to to IN cord-005453-4057qib7 15664 16 limiting limit VBG cord-005453-4057qib7 15664 17 their -PRON- PRP$ cord-005453-4057qib7 15664 18 social social JJ cord-005453-4057qib7 15664 19 experience experience NN cord-005453-4057qib7 15664 20 and and CC cord-005453-4057qib7 15664 21 lead lead VB cord-005453-4057qib7 15664 22 to to IN cord-005453-4057qib7 15664 23 specific specific JJ cord-005453-4057qib7 15664 24 deformities deformity NNS cord-005453-4057qib7 15664 25 of of IN cord-005453-4057qib7 15664 26 individuality individuality NN cord-005453-4057qib7 15664 27 , , , cord-005453-4057qib7 15664 28 including include VBG cord-005453-4057qib7 15664 29 in in IN cord-005453-4057qib7 15664 30 the the DT cord-005453-4057qib7 15664 31 sphere sphere NN cord-005453-4057qib7 15664 32 of of IN cord-005453-4057qib7 15664 33 gender gender NN cord-005453-4057qib7 15664 34 identity identity NN cord-005453-4057qib7 15664 35 . . . cord-005453-4057qib7 15665 1 We -PRON- PRP cord-005453-4057qib7 15665 2 consider consider VBP cord-005453-4057qib7 15665 3 advisable advisable JJ cord-005453-4057qib7 15665 4 to to TO cord-005453-4057qib7 15665 5 introduce introduce VB cord-005453-4057qib7 15665 6 thematic thematic JJ cord-005453-4057qib7 15665 7 group group NN cord-005453-4057qib7 15665 8 counseling counseling NN cord-005453-4057qib7 15665 9 of of IN cord-005453-4057qib7 15665 10 parents parent NNS cord-005453-4057qib7 15665 11 within within IN cord-005453-4057qib7 15665 12 the the DT cord-005453-4057qib7 15665 13 framework framework NN cord-005453-4057qib7 15665 14 of of IN cord-005453-4057qib7 15665 15 the the DT cord-005453-4057qib7 15665 16 " " `` cord-005453-4057qib7 15665 17 Patient Patient NNP cord-005453-4057qib7 15665 18 's 's POS cord-005453-4057qib7 15665 19 School School NNP cord-005453-4057qib7 15665 20 " " '' cord-005453-4057qib7 15665 21 in in IN cord-005453-4057qib7 15665 22 psychological psychological JJ cord-005453-4057qib7 15665 23 treatment treatment NN cord-005453-4057qib7 15665 24 support support NN cord-005453-4057qib7 15665 25 in in IN cord-005453-4057qib7 15665 26 the the DT cord-005453-4057qib7 15665 27 clinic clinic NN cord-005453-4057qib7 15665 28 . . . cord-005453-4057qib7 15666 1 Early early JJ cord-005453-4057qib7 15666 2 diagnosis diagnosis NN cord-005453-4057qib7 15666 3 of of IN cord-005453-4057qib7 15666 4 the the DT cord-005453-4057qib7 15666 5 personal personal JJ cord-005453-4057qib7 15666 6 aspects aspect NNS cord-005453-4057qib7 15666 7 of of IN cord-005453-4057qib7 15666 8 the the DT cord-005453-4057qib7 15666 9 psychosexual psychosexual JJ cord-005453-4057qib7 15666 10 development development NN cord-005453-4057qib7 15666 11 of of IN cord-005453-4057qib7 15666 12 adolescents adolescent NNS cord-005453-4057qib7 15666 13 after after IN cord-005453-4057qib7 15666 14 HSCT HSCT NNP cord-005453-4057qib7 15666 15 allows allow VBZ cord-005453-4057qib7 15666 16 for for IN cord-005453-4057qib7 15666 17 timely timely JJ cord-005453-4057qib7 15666 18 identification identification NN cord-005453-4057qib7 15666 19 of of IN cord-005453-4057qib7 15666 20 individual individual JJ cord-005453-4057qib7 15666 21 problems problem NNS cord-005453-4057qib7 15666 22 in in IN cord-005453-4057qib7 15666 23 this this DT cord-005453-4057qib7 15666 24 area area NN cord-005453-4057qib7 15666 25 and and CC cord-005453-4057qib7 15666 26 identification identification NN cord-005453-4057qib7 15666 27 of of IN cord-005453-4057qib7 15666 28 general general JJ cord-005453-4057qib7 15666 29 trends trend NNS cord-005453-4057qib7 15666 30 in in IN cord-005453-4057qib7 15666 31 the the DT cord-005453-4057qib7 15666 32 long long JJ cord-005453-4057qib7 15666 33 term term NN cord-005453-4057qib7 15666 34 after after IN cord-005453-4057qib7 15666 35 HSCT.Disclosure hsct.disclosure CD cord-005453-4057qib7 15666 36 : : : cord-005453-4057qib7 15667 1 All all DT cord-005453-4057qib7 15667 2 authors author NNS cord-005453-4057qib7 15667 3 -nothing -nothe VBG cord-005453-4057qib7 15667 4 to to TO cord-005453-4057qib7 15667 5 disclose disclose VB cord-005453-4057qib7 15667 6 . . . cord-005453-4057qib7 15668 1 Abnormalities abnormality NNS cord-005453-4057qib7 15668 2 in in IN cord-005453-4057qib7 15668 3 the the DT cord-005453-4057qib7 15668 4 morphology morphology NN cord-005453-4057qib7 15668 5 of of IN cord-005453-4057qib7 15668 6 the the DT cord-005453-4057qib7 15668 7 umbilical umbilical JJ cord-005453-4057qib7 15668 8 cord cord NN cord-005453-4057qib7 15668 9 blood blood NN cord-005453-4057qib7 15668 10 obtained obtain VBN cord-005453-4057qib7 15668 11 at at IN cord-005453-4057qib7 15668 12 delivery delivery NN cord-005453-4057qib7 15668 13 from from IN cord-005453-4057qib7 15668 14 children child NNS cord-005453-4057qib7 15668 15 who who WP cord-005453-4057qib7 15668 16 received receive VBD cord-005453-4057qib7 15668 17 a a DT cord-005453-4057qib7 15668 18 diagnosis diagnosis NN cord-005453-4057qib7 15668 19 of of IN cord-005453-4057qib7 15668 20 cerebral cerebral JJ cord-005453-4057qib7 15668 21 palsy palsy NN cord-005453-4057qib7 15668 22 Maciej Maciej NNP cord-005453-4057qib7 15668 23 Boruczkowski Boruczkowski NNP cord-005453-4057qib7 15668 24 1 1 CD cord-005453-4057qib7 15668 25 , , , cord-005453-4057qib7 15668 26 Izabela Izabela NNP cord-005453-4057qib7 15668 27 Zdolińska Zdolińska NNP cord-005453-4057qib7 15668 28 - - HYPH cord-005453-4057qib7 15668 29 Malinowska Malinowska NNP cord-005453-4057qib7 15668 30 2 2 CD cord-005453-4057qib7 15668 31 , , , cord-005453-4057qib7 15668 32 Maciej Maciej NNP cord-005453-4057qib7 15668 33 Rojek Rojek NNP cord-005453-4057qib7 15668 34 2 2 CD cord-005453-4057qib7 15668 35 , , , cord-005453-4057qib7 15668 36 Dariusz Dariusz NNP cord-005453-4057qib7 15668 37 Boruczkowski Boruczkowski NNP cord-005453-4057qib7 15668 38 2Background 2background CD cord-005453-4057qib7 15668 39 : : : cord-005453-4057qib7 15669 1 Embryonal embryonal JJ cord-005453-4057qib7 15669 2 brain brain NN cord-005453-4057qib7 15669 3 tumors tumor NNS cord-005453-4057qib7 15669 4 are be VBP cord-005453-4057qib7 15669 5 the the DT cord-005453-4057qib7 15669 6 most most RBS cord-005453-4057qib7 15669 7 common common JJ cord-005453-4057qib7 15669 8 malignancies malignancy NNS cord-005453-4057qib7 15669 9 in in IN cord-005453-4057qib7 15669 10 infants infant NNS cord-005453-4057qib7 15669 11 less less JJR cord-005453-4057qib7 15669 12 than than IN cord-005453-4057qib7 15669 13 48 48 CD cord-005453-4057qib7 15669 14 months month NNS cord-005453-4057qib7 15669 15 of of IN cord-005453-4057qib7 15669 16 age age NN cord-005453-4057qib7 15669 17 . . . cord-005453-4057qib7 15670 1 Histologically Histologically NNP cord-005453-4057qib7 15670 2 characterized characterize VBN cord-005453-4057qib7 15670 3 as as IN cord-005453-4057qib7 15670 4 undifferentiated undifferentiated JJ cord-005453-4057qib7 15670 5 small small JJ cord-005453-4057qib7 15670 6 round round JJ cord-005453-4057qib7 15670 7 cell cell NN cord-005453-4057qib7 15670 8 tumors tumor NNS cord-005453-4057qib7 15670 9 , , , cord-005453-4057qib7 15670 10 all all DT cord-005453-4057qib7 15670 11 are be VBP cord-005453-4057qib7 15670 12 similarly similarly RB cord-005453-4057qib7 15670 13 aggressive aggressive JJ cord-005453-4057qib7 15670 14 , , , cord-005453-4057qib7 15670 15 have have VBP cord-005453-4057qib7 15670 16 a a DT cord-005453-4057qib7 15670 17 tendency tendency NN cord-005453-4057qib7 15670 18 to to TO cord-005453-4057qib7 15670 19 disseminate disseminate VB cord-005453-4057qib7 15670 20 throughout throughout IN cord-005453-4057qib7 15670 21 central central JJ cord-005453-4057qib7 15670 22 nervous nervous JJ cord-005453-4057qib7 15670 23 system system NN cord-005453-4057qib7 15670 24 and and CC cord-005453-4057qib7 15670 25 very very RB cord-005453-4057qib7 15670 26 poor poor JJ cord-005453-4057qib7 15670 27 prognosis prognosis NN cord-005453-4057qib7 15670 28 . . . cord-005453-4057qib7 15671 1 We -PRON- PRP cord-005453-4057qib7 15671 2 tried try VBD cord-005453-4057qib7 15671 3 to to TO cord-005453-4057qib7 15671 4 assess assess VB cord-005453-4057qib7 15671 5 the the DT cord-005453-4057qib7 15671 6 effectiveness effectiveness NN cord-005453-4057qib7 15671 7 of of IN cord-005453-4057qib7 15671 8 tandem tandem JJ cord-005453-4057qib7 15671 9 highdose highdose NN cord-005453-4057qib7 15671 10 chemotherapy chemotherapy NN cord-005453-4057qib7 15671 11 ( ( -LRB- cord-005453-4057qib7 15671 12 HDCT HDCT NNP cord-005453-4057qib7 15671 13 ) ) -RRB- cord-005453-4057qib7 15671 14 with with IN cord-005453-4057qib7 15671 15 autologous autologous JJ cord-005453-4057qib7 15671 16 hematopoietic hematopoietic JJ cord-005453-4057qib7 15671 17 stem stem NN cord-005453-4057qib7 15671 18 - - HYPH cord-005453-4057qib7 15671 19 cell cell NN cord-005453-4057qib7 15671 20 transplantation transplantation NN cord-005453-4057qib7 15671 21 ( ( -LRB- cord-005453-4057qib7 15671 22 auto auto NN cord-005453-4057qib7 15671 23 - - HYPH cord-005453-4057qib7 15671 24 HSCT HSCT NNP cord-005453-4057qib7 15671 25 ) ) -RRB- cord-005453-4057qib7 15671 26 in in IN cord-005453-4057qib7 15671 27 this this DT cord-005453-4057qib7 15671 28 patient patient NN cord-005453-4057qib7 15671 29 group group NN cord-005453-4057qib7 15671 30 . . . cord-005453-4057qib7 15672 1 Methods method NNS cord-005453-4057qib7 15672 2 : : : cord-005453-4057qib7 15673 1 From from IN cord-005453-4057qib7 15673 2 2010 2010 CD cord-005453-4057qib7 15673 3 to to IN cord-005453-4057qib7 15673 4 2018 2018 CD cord-005453-4057qib7 15673 5 , , , cord-005453-4057qib7 15673 6 52 52 CD cord-005453-4057qib7 15673 7 infants infant NNS cord-005453-4057qib7 15673 8 under under IN cord-005453-4057qib7 15673 9 48 48 CD cord-005453-4057qib7 15673 10 months month NNS cord-005453-4057qib7 15673 11 with with IN cord-005453-4057qib7 15673 12 different different JJ cord-005453-4057qib7 15673 13 primary primary JJ cord-005453-4057qib7 15673 14 embryonal embryonal JJ cord-005453-4057qib7 15673 15 brain brain NN cord-005453-4057qib7 15673 16 tumors tumor NNS cord-005453-4057qib7 15673 17 such such JJ cord-005453-4057qib7 15673 18 as as IN cord-005453-4057qib7 15673 19 medulloblastoma medulloblastoma NNP cord-005453-4057qib7 15673 20 ( ( -LRB- cord-005453-4057qib7 15673 21 N=28 N=28 NNP cord-005453-4057qib7 15673 22 ) ) -RRB- cord-005453-4057qib7 15673 23 , , , cord-005453-4057qib7 15673 24 different different JJ cord-005453-4057qib7 15673 25 PNET PNET NNP cord-005453-4057qib7 15673 26 NOS NOS NNP cord-005453-4057qib7 15673 27 ( ( -LRB- cord-005453-4057qib7 15673 28 N=10 N=10 NNP cord-005453-4057qib7 15673 29 ) ) -RRB- cord-005453-4057qib7 15673 30 , , , cord-005453-4057qib7 15673 31 pineoblastoma pineoblastoma NNP cord-005453-4057qib7 15673 32 ( ( -LRB- cord-005453-4057qib7 15673 33 N=3 N=3 NNP cord-005453-4057qib7 15673 34 ) ) -RRB- cord-005453-4057qib7 15673 35 , , , cord-005453-4057qib7 15673 36 atypical atypical JJ cord-005453-4057qib7 15673 37 teratoid teratoid NN cord-005453-4057qib7 15673 38 rhabdoid rhabdoid NN cord-005453-4057qib7 15673 39 tumor tumor NN cord-005453-4057qib7 15673 40 ( ( -LRB- cord-005453-4057qib7 15673 41 N=3 N=3 NNP cord-005453-4057qib7 15673 42 ) ) -RRB- cord-005453-4057qib7 15673 43 , , , cord-005453-4057qib7 15673 44 ETMR ETMR NNP cord-005453-4057qib7 15673 45 ( ( -LRB- cord-005453-4057qib7 15673 46 N=8 N=8 NNP cord-005453-4057qib7 15673 47 ) ) -RRB- cord-005453-4057qib7 15673 48 after after IN cord-005453-4057qib7 15673 49 surgical surgical JJ cord-005453-4057qib7 15673 50 resection resection NN cord-005453-4057qib7 15673 51 and and CC cord-005453-4057qib7 15673 52 induction induction NN cord-005453-4057qib7 15674 1 chemotherapy chemotherapy NN cord-005453-4057qib7 15674 2 were be VBD cord-005453-4057qib7 15674 3 planned plan VBN cord-005453-4057qib7 15674 4 to to TO cord-005453-4057qib7 15674 5 receive receive VB cord-005453-4057qib7 15674 6 tandem tandem JJ cord-005453-4057qib7 15674 7 HDCT HDCT NNP cord-005453-4057qib7 15674 8 with with IN cord-005453-4057qib7 15674 9 auto auto NN cord-005453-4057qib7 15674 10 - - HYPH cord-005453-4057qib7 15674 11 HSCT HSCT NNP cord-005453-4057qib7 15674 12 . . . cord-005453-4057qib7 15675 1 Nine nine CD cord-005453-4057qib7 15675 2 patients patient NNS cord-005453-4057qib7 15675 3 were be VBD cord-005453-4057qib7 15675 4 conducted conduct VBN cord-005453-4057qib7 15675 5 only only RB cord-005453-4057qib7 15675 6 single single JJ cord-005453-4057qib7 15675 7 transplantation transplantation NN cord-005453-4057qib7 15675 8 because because IN cord-005453-4057qib7 15675 9 of of IN cord-005453-4057qib7 15675 10 the the DT cord-005453-4057qib7 15675 11 development development NN cord-005453-4057qib7 15675 12 of of IN cord-005453-4057qib7 15675 13 lifethreatening lifethreatening JJ cord-005453-4057qib7 15675 14 complications complication NNS cord-005453-4057qib7 15675 15 after after IN cord-005453-4057qib7 15675 16 the the DT cord-005453-4057qib7 15675 17 first first JJ cord-005453-4057qib7 15675 18 HDCT HDCT NNP cord-005453-4057qib7 15675 19 ( ( -LRB- cord-005453-4057qib7 15675 20 N=4 N=4 NNP cord-005453-4057qib7 15675 21 ) ) -RRB- cord-005453-4057qib7 15675 22 or or CC cord-005453-4057qib7 15675 23 the the DT cord-005453-4057qib7 15675 24 emergence emergence NN cord-005453-4057qib7 15675 25 of of IN cord-005453-4057qib7 15675 26 early early JJ cord-005453-4057qib7 15675 27 disease disease NN cord-005453-4057qib7 15675 28 progression progression NN cord-005453-4057qib7 15675 29 ( ( -LRB- cord-005453-4057qib7 15675 30 N=5 N=5 NNP cord-005453-4057qib7 15675 31 ) ) -RRB- cord-005453-4057qib7 15675 32 . . . cord-005453-4057qib7 15676 1 At at IN cord-005453-4057qib7 15676 2 the the DT cord-005453-4057qib7 15676 3 moment moment NN cord-005453-4057qib7 15676 4 of of IN cord-005453-4057qib7 15676 5 HDCT HDCT NNP cord-005453-4057qib7 15676 6 31 31 CD cord-005453-4057qib7 15676 7 patients patient NNS cord-005453-4057qib7 15676 8 were be VBD cord-005453-4057qib7 15676 9 in in IN cord-005453-4057qib7 15676 10 complete complete JJ cord-005453-4057qib7 15676 11 remission remission NN cord-005453-4057qib7 15676 12 ( ( -LRB- cord-005453-4057qib7 15676 13 CR CR NNP cord-005453-4057qib7 15676 14 ) ) -RRB- cord-005453-4057qib7 15676 15 , , , cord-005453-4057qib7 15676 16 20 20 CD cord-005453-4057qib7 15676 17 patients patient NNS cord-005453-4057qib7 15676 18 were be VBD cord-005453-4057qib7 15676 19 in in IN cord-005453-4057qib7 15676 20 partial partial JJ cord-005453-4057qib7 15676 21 remission remission NN cord-005453-4057qib7 15676 22 ( ( -LRB- cord-005453-4057qib7 15676 23 PR PR NNP cord-005453-4057qib7 15676 24 ) ) -RRB- cord-005453-4057qib7 15676 25 and and CC cord-005453-4057qib7 15676 26 1 1 CD cord-005453-4057qib7 15676 27 patient patient NN cord-005453-4057qib7 15676 28 had have VBD cord-005453-4057qib7 15676 29 stable stable JJ cord-005453-4057qib7 15676 30 disease disease NN cord-005453-4057qib7 15676 31 ( ( -LRB- cord-005453-4057qib7 15676 32 SD sd NN cord-005453-4057qib7 15676 33 ) ) -RRB- cord-005453-4057qib7 15676 34 . . . cord-005453-4057qib7 15677 1 The the DT cord-005453-4057qib7 15677 2 conditioning conditioning NN cord-005453-4057qib7 15677 3 regimen regimen NN cord-005453-4057qib7 15677 4 for for IN cord-005453-4057qib7 15677 5 tandem tandem JJ cord-005453-4057qib7 15677 6 auto auto NN cord-005453-4057qib7 15677 7 - - HYPH cord-005453-4057qib7 15677 8 HSCT HSCT NNP cord-005453-4057qib7 15677 9 were be VBD cord-005453-4057qib7 15677 10 : : : cord-005453-4057qib7 15677 11 the the DT cord-005453-4057qib7 15677 12 first first JJ cord-005453-4057qib7 15677 13 HDCT HDCT NNP cord-005453-4057qib7 15677 14 was be VBD cord-005453-4057qib7 15677 15 carboplatin carboplatin NNS cord-005453-4057qib7 15677 16 and and CC cord-005453-4057qib7 15677 17 etoposide etoposide VBD cord-005453-4057qib7 15677 18 , , , cord-005453-4057qib7 15677 19 the the DT cord-005453-4057qib7 15677 20 second second JJ cord-005453-4057qib7 15677 21 was be VBD cord-005453-4057qib7 15677 22 thiotepa thiotepa JJ cord-005453-4057qib7 15677 23 and and CC cord-005453-4057qib7 15677 24 cyclophosphamide cyclophosphamide VBD cord-005453-4057qib7 15677 25 , , , cord-005453-4057qib7 15677 26 both both DT cord-005453-4057qib7 15677 27 with with IN cord-005453-4057qib7 15677 28 intraventricular intraventricular NNP cord-005453-4057qib7 15677 29 methotrexate methotrexate NNP cord-005453-4057qib7 15677 30 . . . cord-005453-4057qib7 15678 1 Results result NNS cord-005453-4057qib7 15678 2 : : : cord-005453-4057qib7 15679 1 The the DT cord-005453-4057qib7 15679 2 median median JJ cord-005453-4057qib7 15679 3 follow follow NN cord-005453-4057qib7 15679 4 - - HYPH cord-005453-4057qib7 15679 5 up up NN cord-005453-4057qib7 15679 6 is be VBZ cord-005453-4057qib7 15679 7 24 24 CD cord-005453-4057qib7 15679 8 months month NNS cord-005453-4057qib7 15679 9 ( ( -LRB- cord-005453-4057qib7 15679 10 range range NN cord-005453-4057qib7 15679 11 , , , cord-005453-4057qib7 15679 12 6 6 CD cord-005453-4057qib7 15679 13 - - SYM cord-005453-4057qib7 15679 14 85 85 CD cord-005453-4057qib7 15679 15 ) ) -RRB- cord-005453-4057qib7 15679 16 . . . cord-005453-4057qib7 15680 1 The the DT cord-005453-4057qib7 15680 2 median median JJ cord-005453-4057qib7 15680 3 time time NN cord-005453-4057qib7 15680 4 to to IN cord-005453-4057qib7 15680 5 engraftment engraftment NN cord-005453-4057qib7 15680 6 after after IN cord-005453-4057qib7 15680 7 the the DT cord-005453-4057qib7 15680 8 first first JJ cord-005453-4057qib7 15680 9 auto auto NN cord-005453-4057qib7 15680 10 - - HYPH cord-005453-4057qib7 15680 11 HSCT HSCT NNP cord-005453-4057qib7 15680 12 was be VBD cord-005453-4057qib7 15680 13 Background background NN cord-005453-4057qib7 15680 14 : : : cord-005453-4057qib7 15681 1 A a DT cord-005453-4057qib7 15681 2 series series NN cord-005453-4057qib7 15681 3 of of IN cord-005453-4057qib7 15681 4 findings finding NNS cord-005453-4057qib7 15681 5 suggest suggest VBP cord-005453-4057qib7 15681 6 that that IN cord-005453-4057qib7 15681 7 optimizing optimize VBG cord-005453-4057qib7 15681 8 natural natural JJ cord-005453-4057qib7 15681 9 killer killer NN cord-005453-4057qib7 15681 10 ( ( -LRB- cord-005453-4057qib7 15681 11 NK NK NNP cord-005453-4057qib7 15681 12 ) ) -RRB- cord-005453-4057qib7 15681 13 cell cell NN cord-005453-4057qib7 15681 14 reactivity reactivity NN cord-005453-4057qib7 15681 15 could could MD cord-005453-4057qib7 15681 16 further further RB cord-005453-4057qib7 15681 17 improve improve VB cord-005453-4057qib7 15681 18 outcome outcome NN cord-005453-4057qib7 15681 19 after after IN cord-005453-4057qib7 15681 20 allogeneic allogeneic JJ cord-005453-4057qib7 15681 21 hematopoietic hematopoietic JJ cord-005453-4057qib7 15681 22 cell cell NN cord-005453-4057qib7 15681 23 transplantation transplantation NN cord-005453-4057qib7 15681 24 ( ( -LRB- cord-005453-4057qib7 15681 25 alloHCT alloHCT NNP cord-005453-4057qib7 15681 26 ) ) -RRB- cord-005453-4057qib7 15681 27 . . . cord-005453-4057qib7 15682 1 This this DT cord-005453-4057qib7 15682 2 could could MD cord-005453-4057qib7 15682 3 be be VB cord-005453-4057qib7 15682 4 achieved achieve VBN cord-005453-4057qib7 15682 5 by by IN cord-005453-4057qib7 15682 6 killer killer NN cord-005453-4057qib7 15682 7 cell cell NN cord-005453-4057qib7 15682 8 immunoglobulin immunoglobulin NN cord-005453-4057qib7 15682 9 - - HYPH cord-005453-4057qib7 15682 10 like like JJ cord-005453-4057qib7 15682 11 receptor receptor NN cord-005453-4057qib7 15682 12 ( ( -LRB- cord-005453-4057qib7 15682 13 KIR KIR NNP cord-005453-4057qib7 15682 14 ) ) -RRB- cord-005453-4057qib7 15682 15 genotype genotype NN cord-005453-4057qib7 15682 16 informed inform VBN cord-005453-4057qib7 15682 17 donor donor NN cord-005453-4057qib7 15682 18 selection selection NN cord-005453-4057qib7 15682 19 . . . cord-005453-4057qib7 15683 1 An an DT cord-005453-4057qib7 15683 2 enhanced enhanced JJ cord-005453-4057qib7 15683 3 Receptor Receptor NNP cord-005453-4057qib7 15683 4 - - HYPH cord-005453-4057qib7 15683 5 Ligand Ligand NNP cord-005453-4057qib7 15683 6 model model NN cord-005453-4057qib7 15683 7 which which WDT cord-005453-4057qib7 15683 8 used use VBD cord-005453-4057qib7 15683 9 KIR2DS1 kir2ds1 CD cord-005453-4057qib7 15683 10 and and CC cord-005453-4057qib7 15683 11 KIR3DL1 kir3dl1 CD cord-005453-4057qib7 15683 12 donor donor NN cord-005453-4057qib7 15683 13 genotype genotype NN cord-005453-4057qib7 15683 14 information information NN cord-005453-4057qib7 15683 15 to to TO cord-005453-4057qib7 15683 16 augment augment VB cord-005453-4057qib7 15683 17 NK NK NNP cord-005453-4057qib7 15683 18 cell cell NN cord-005453-4057qib7 15683 19 activation activation NN cord-005453-4057qib7 15683 20 and and CC cord-005453-4057qib7 15683 21 minimize minimize VB cord-005453-4057qib7 15683 22 inhibition inhibition NN cord-005453-4057qib7 15683 23 demonstrated demonstrate VBD cord-005453-4057qib7 15683 24 improved improved JJ cord-005453-4057qib7 15683 25 survival survival NN cord-005453-4057qib7 15683 26 in in IN cord-005453-4057qib7 15683 27 one one CD cord-005453-4057qib7 15683 28 large large JJ cord-005453-4057qib7 15683 29 AML AML NNP cord-005453-4057qib7 15683 30 study study NN cord-005453-4057qib7 15683 31 ( ( -LRB- cord-005453-4057qib7 15683 32 Boudreau Boudreau NNP cord-005453-4057qib7 15683 33 et et NNP cord-005453-4057qib7 15683 34 al al NNP cord-005453-4057qib7 15683 35 , , , cord-005453-4057qib7 15683 36 JCO JCO NNP cord-005453-4057qib7 15683 37 2017 2017 CD cord-005453-4057qib7 15683 38 ) ) -RRB- cord-005453-4057qib7 15683 39 . . . cord-005453-4057qib7 15684 1 Likewise likewise RB cord-005453-4057qib7 15684 2 , , , cord-005453-4057qib7 15684 3 a a DT cord-005453-4057qib7 15684 4 second second JJ cord-005453-4057qib7 15684 5 model model NN cord-005453-4057qib7 15684 6 built build VBN cord-005453-4057qib7 15684 7 on on IN cord-005453-4057qib7 15684 8 the the DT cord-005453-4057qib7 15684 9 classification classification NN cord-005453-4057qib7 15684 10 of of IN cord-005453-4057qib7 15684 11 centromeric centromeric NNP cord-005453-4057qib7 15684 12 and and CC cord-005453-4057qib7 15684 13 telomeric telomeric JJ cord-005453-4057qib7 15684 14 KIR KIR NNP cord-005453-4057qib7 15684 15 haplotype haplotype NN cord-005453-4057qib7 15684 16 motifs motif NNS cord-005453-4057qib7 15684 17 , , , cord-005453-4057qib7 15684 18 also also RB cord-005453-4057qib7 15684 19 predicted predict VBD cord-005453-4057qib7 15684 20 mortality mortality NN cord-005453-4057qib7 15684 21 after after IN cord-005453-4057qib7 15684 22 alloHCT alloHCT NNP cord-005453-4057qib7 15684 23 for for IN cord-005453-4057qib7 15684 24 AML AML NNP cord-005453-4057qib7 15684 25 ( ( -LRB- cord-005453-4057qib7 15684 26 Cooley Cooley NNP cord-005453-4057qib7 15684 27 et et NNP cord-005453-4057qib7 15684 28 al al NNP cord-005453-4057qib7 15684 29 , , , cord-005453-4057qib7 15684 30 Blood blood NN cord-005453-4057qib7 15684 31 2010 2010 CD cord-005453-4057qib7 15684 32 ) ) -RRB- cord-005453-4057qib7 15684 33 . . . cord-005453-4057qib7 15685 1 This this DT cord-005453-4057qib7 15685 2 joint joint JJ cord-005453-4057qib7 15685 3 EBMT EBMT NNP cord-005453-4057qib7 15685 4 and and CC cord-005453-4057qib7 15685 5 CIBMTR CIBMTR NNP cord-005453-4057qib7 15685 6 study study NN cord-005453-4057qib7 15685 7 aimed aim VBN cord-005453-4057qib7 15685 8 at at IN cord-005453-4057qib7 15685 9 validating validate VBG cord-005453-4057qib7 15685 10 the the DT cord-005453-4057qib7 15685 11 two two CD cord-005453-4057qib7 15685 12 approaches approach NNS cord-005453-4057qib7 15685 13 in in IN cord-005453-4057qib7 15685 14 an an DT cord-005453-4057qib7 15685 15 independent independent JJ cord-005453-4057qib7 15685 16 cohort cohort NN cord-005453-4057qib7 15685 17 of of IN cord-005453-4057qib7 15685 18 patients patient NNS cord-005453-4057qib7 15685 19 with with IN cord-005453-4057qib7 15685 20 MDS MDS NNP cord-005453-4057qib7 15685 21 or or CC cord-005453-4057qib7 15685 22 secondary secondary JJ cord-005453-4057qib7 15685 23 AML.Methods aml.method NNS cord-005453-4057qib7 15685 24 : : : cord-005453-4057qib7 15686 1 Donor donor NN cord-005453-4057qib7 15686 2 samples sample NNS cord-005453-4057qib7 15686 3 were be VBD cord-005453-4057qib7 15686 4 retrieved retrieve VBN cord-005453-4057qib7 15686 5 from from IN cord-005453-4057qib7 15686 6 the the DT cord-005453-4057qib7 15686 7 Collaborative Collaborative NNP cord-005453-4057qib7 15686 8 Biobank Biobank NNP cord-005453-4057qib7 15686 9 ( ( -LRB- cord-005453-4057qib7 15686 10 Dresden Dresden NNP cord-005453-4057qib7 15686 11 , , , cord-005453-4057qib7 15686 12 Germany Germany NNP cord-005453-4057qib7 15686 13 ) ) -RRB- cord-005453-4057qib7 15686 14 and and CC cord-005453-4057qib7 15686 15 mapped map VBN cord-005453-4057qib7 15686 16 to to IN cord-005453-4057qib7 15686 17 patient patient JJ cord-005453-4057qib7 15686 18 outcome outcome NN cord-005453-4057qib7 15686 19 data datum NNS cord-005453-4057qib7 15686 20 extracted extract VBN cord-005453-4057qib7 15686 21 from from IN cord-005453-4057qib7 15686 22 the the DT cord-005453-4057qib7 15686 23 EBMT EBMT NNP cord-005453-4057qib7 15686 24 and and CC cord-005453-4057qib7 15686 25 CIBMTR CIBMTR NNP cord-005453-4057qib7 15686 26 . . . cord-005453-4057qib7 15687 1 Genotyping genotype VBG cord-005453-4057qib7 15687 2 of of IN cord-005453-4057qib7 15687 3 all all DT cord-005453-4057qib7 15687 4 KIR KIR NNP cord-005453-4057qib7 15687 5 genes gene NNS cord-005453-4057qib7 15687 6 by by IN cord-005453-4057qib7 15687 7 sequencing sequence VBG cord-005453-4057qib7 15687 8 exons exon NNS cord-005453-4057qib7 15687 9 3 3 CD cord-005453-4057qib7 15687 10 , , , cord-005453-4057qib7 15687 11 4 4 CD cord-005453-4057qib7 15687 12 , , , cord-005453-4057qib7 15687 13 5 5 CD cord-005453-4057qib7 15687 14 , , , cord-005453-4057qib7 15687 15 7 7 CD cord-005453-4057qib7 15687 16 , , , cord-005453-4057qib7 15687 17 8 8 CD cord-005453-4057qib7 15687 18 , , , cord-005453-4057qib7 15687 19 and and CC cord-005453-4057qib7 15687 20 9 9 CD cord-005453-4057qib7 15687 21 was be VBD cord-005453-4057qib7 15687 22 performed perform VBN cord-005453-4057qib7 15687 23 by by IN cord-005453-4057qib7 15687 24 high high JJ cord-005453-4057qib7 15687 25 resolution resolution NN cord-005453-4057qib7 15687 26 amplicon amplicon NN cord-005453-4057qib7 15687 27 - - HYPH cord-005453-4057qib7 15687 28 based base VBN cord-005453-4057qib7 15687 29 next next JJ cord-005453-4057qib7 15687 30 generation generation NN cord-005453-4057qib7 15687 31 sequencing sequencing NN cord-005453-4057qib7 15687 32 . . . cord-005453-4057qib7 15688 1 The the DT cord-005453-4057qib7 15688 2 impact impact NN cord-005453-4057qib7 15688 3 of of IN cord-005453-4057qib7 15688 4 the the DT cord-005453-4057qib7 15688 5 classifiers classifier NNS cord-005453-4057qib7 15688 6 on on IN cord-005453-4057qib7 15688 7 time time NN cord-005453-4057qib7 15688 8 - - HYPH cord-005453-4057qib7 15688 9 to to IN cord-005453-4057qib7 15688 10 - - HYPH cord-005453-4057qib7 15688 11 event event NN cord-005453-4057qib7 15688 12 outcomes outcome NNS cord-005453-4057qib7 15688 13 was be VBD cord-005453-4057qib7 15688 14 tested test VBN cord-005453-4057qib7 15688 15 in in IN cord-005453-4057qib7 15688 16 cause cause NN cord-005453-4057qib7 15688 17 - - HYPH cord-005453-4057qib7 15688 18 specific specific JJ cord-005453-4057qib7 15688 19 Cox Cox NNP cord-005453-4057qib7 15688 20 regression regression NN cord-005453-4057qib7 15688 21 models model NNS cord-005453-4057qib7 15688 22 adjusted adjust VBN cord-005453-4057qib7 15688 23 for for IN cord-005453-4057qib7 15688 24 patient patient JJ cord-005453-4057qib7 15688 25 age age NN cord-005453-4057qib7 15688 26 , , , cord-005453-4057qib7 15688 27 a a DT cord-005453-4057qib7 15688 28 modified modify VBN cord-005453-4057qib7 15688 29 disease disease NN cord-005453-4057qib7 15688 30 risk risk NN cord-005453-4057qib7 15688 31 index index NN cord-005453-4057qib7 15688 32 , , , cord-005453-4057qib7 15688 33 performance performance NN cord-005453-4057qib7 15688 34 status status NN cord-005453-4057qib7 15688 35 , , , cord-005453-4057qib7 15688 36 donor donor NN cord-005453-4057qib7 15688 37 age age NN cord-005453-4057qib7 15688 38 , , , cord-005453-4057qib7 15688 39 HLA HLA NNP cord-005453-4057qib7 15688 40 - - HYPH cord-005453-4057qib7 15688 41 match match NN cord-005453-4057qib7 15688 42 , , , cord-005453-4057qib7 15688 43 sex sex NN cord-005453-4057qib7 15688 44 match match NN cord-005453-4057qib7 15688 45 , , , cord-005453-4057qib7 15688 46 CMV CMV NNP cord-005453-4057qib7 15688 47 match match NN cord-005453-4057qib7 15688 48 , , , cord-005453-4057qib7 15688 49 conditioning conditioning NN cord-005453-4057qib7 15688 50 intensity intensity NN cord-005453-4057qib7 15688 51 , , , cord-005453-4057qib7 15688 52 type type NN cord-005453-4057qib7 15688 53 of of IN cord-005453-4057qib7 15688 54 T t NN cord-005453-4057qib7 15688 55 - - HYPH cord-005453-4057qib7 15688 56 cell cell NN cord-005453-4057qib7 15688 57 depletion depletion NN cord-005453-4057qib7 15688 58 and and CC cord-005453-4057qib7 15688 59 graft graft NN cord-005453-4057qib7 15688 60 type type NN cord-005453-4057qib7 15688 61 . . . cord-005453-4057qib7 15689 1 Results result NNS cord-005453-4057qib7 15689 2 : : : cord-005453-4057qib7 15690 1 Clinical clinical JJ cord-005453-4057qib7 15690 2 data datum NNS cord-005453-4057qib7 15690 3 from from IN cord-005453-4057qib7 15690 4 1704 1704 CD cord-005453-4057qib7 15690 5 patients patient NNS cord-005453-4057qib7 15690 6 and and CC cord-005453-4057qib7 15690 7 corresponding correspond VBG cord-005453-4057qib7 15690 8 donor donor NN cord-005453-4057qib7 15690 9 genotype genotype NN cord-005453-4057qib7 15690 10 information information NN cord-005453-4057qib7 15690 11 were be VBD cord-005453-4057qib7 15690 12 analyzed analyze VBN cord-005453-4057qib7 15690 13 . . . cord-005453-4057qib7 15691 1 The the DT cord-005453-4057qib7 15691 2 median median JJ cord-005453-4057qib7 15691 3 age age NN cord-005453-4057qib7 15691 4 at at IN cord-005453-4057qib7 15691 5 alloHCT alloHCT NNP cord-005453-4057qib7 15691 6 was be VBD cord-005453-4057qib7 15691 7 59.4 59.4 CD cord-005453-4057qib7 15691 8 years year NNS cord-005453-4057qib7 15691 9 ( ( -LRB- cord-005453-4057qib7 15691 10 range range NN cord-005453-4057qib7 15691 11 , , , cord-005453-4057qib7 15691 12 18.1 18.1 CD cord-005453-4057qib7 15691 13 to to IN cord-005453-4057qib7 15691 14 79.6 79.6 CD cord-005453-4057qib7 15691 15 years year NNS cord-005453-4057qib7 15691 16 ) ) -RRB- cord-005453-4057qib7 15691 17 . . . cord-005453-4057qib7 15692 1 The the DT cord-005453-4057qib7 15692 2 indication indication NN cord-005453-4057qib7 15692 3 for for IN cord-005453-4057qib7 15692 4 alloHCT alloHCT NNP cord-005453-4057qib7 15692 5 was be VBD cord-005453-4057qib7 15692 6 MDS MDS NNP cord-005453-4057qib7 15692 7 for for IN cord-005453-4057qib7 15692 8 72 72 CD cord-005453-4057qib7 15692 9 % % NN cord-005453-4057qib7 15692 10 and and CC cord-005453-4057qib7 15692 11 sAML saml NN cord-005453-4057qib7 15692 12 for for IN cord-005453-4057qib7 15692 13 28 28 CD cord-005453-4057qib7 15692 14 % % NN cord-005453-4057qib7 15692 15 of of IN cord-005453-4057qib7 15692 16 patients patient NNS cord-005453-4057qib7 15692 17 . . . cord-005453-4057qib7 15693 1 Disease Disease NNP cord-005453-4057qib7 15693 2 risk risk NN cord-005453-4057qib7 15693 3 was be VBD cord-005453-4057qib7 15693 4 low low JJ cord-005453-4057qib7 15693 5 / / SYM cord-005453-4057qib7 15693 6 intermediate intermediate JJ cord-005453-4057qib7 15693 7 and and CC cord-005453-4057qib7 15693 8 high high JJ cord-005453-4057qib7 15693 9 / / , cord-005453-4057qib7 15693 10 very very RB cord-005453-4057qib7 15693 11 high high JJ cord-005453-4057qib7 15693 12 in in IN cord-005453-4057qib7 15693 13 41 41 CD cord-005453-4057qib7 15693 14 % % NN cord-005453-4057qib7 15693 15 and and CC cord-005453-4057qib7 15693 16 59 59 CD cord-005453-4057qib7 15693 17 % % NN cord-005453-4057qib7 15693 18 , , , cord-005453-4057qib7 15693 19 respectively respectively RB cord-005453-4057qib7 15693 20 . . . cord-005453-4057qib7 15694 1 Donors donor NNS cord-005453-4057qib7 15694 2 were be VBD cord-005453-4057qib7 15694 3 10/10 10/10 CD cord-005453-4057qib7 15694 4 matched match VBN cord-005453-4057qib7 15694 5 for for IN cord-005453-4057qib7 15694 6 79 79 CD cord-005453-4057qib7 15694 7 % % NN cord-005453-4057qib7 15694 8 of of IN cord-005453-4057qib7 15694 9 patients patient NNS cord-005453-4057qib7 15694 10 . . . cord-005453-4057qib7 15695 1 Myeloablative Myeloablative NNP cord-005453-4057qib7 15695 2 , , , cord-005453-4057qib7 15695 3 reducedintensity reducedintensity NN cord-005453-4057qib7 15695 4 and and CC cord-005453-4057qib7 15695 5 non non JJ cord-005453-4057qib7 15695 6 - - JJ cord-005453-4057qib7 15695 7 myeloablative myeloablative JJ cord-005453-4057qib7 15695 8 conditioning conditioning NN cord-005453-4057qib7 15695 9 regimens regimen NNS cord-005453-4057qib7 15695 10 were be VBD cord-005453-4057qib7 15695 11 used use VBN cord-005453-4057qib7 15695 12 in in IN cord-005453-4057qib7 15695 13 31 31 CD cord-005453-4057qib7 15695 14 % % NN cord-005453-4057qib7 15695 15 , , , cord-005453-4057qib7 15695 16 57 57 CD cord-005453-4057qib7 15695 17 % % NN cord-005453-4057qib7 15695 18 , , , cord-005453-4057qib7 15695 19 and and CC cord-005453-4057qib7 15695 20 12 12 CD cord-005453-4057qib7 15695 21 % % NN cord-005453-4057qib7 15695 22 of of IN cord-005453-4057qib7 15695 23 patients patient NNS cord-005453-4057qib7 15695 24 , , , cord-005453-4057qib7 15695 25 respectively respectively RB cord-005453-4057qib7 15695 26 . . . cord-005453-4057qib7 15696 1 Peripheral peripheral JJ cord-005453-4057qib7 15696 2 blood blood NN cord-005453-4057qib7 15696 3 stem stem NN cord-005453-4057qib7 15696 4 cells cell NNS cord-005453-4057qib7 15696 5 were be VBD cord-005453-4057qib7 15696 6 the the DT cord-005453-4057qib7 15696 7 predominant predominant JJ cord-005453-4057qib7 15696 8 graft graft NN cord-005453-4057qib7 15696 9 source source NN cord-005453-4057qib7 15696 10 ( ( -LRB- cord-005453-4057qib7 15696 11 93 93 CD cord-005453-4057qib7 15696 12 % % NN cord-005453-4057qib7 15696 13 of of IN cord-005453-4057qib7 15696 14 patients patient NNS cord-005453-4057qib7 15696 15 ) ) -RRB- cord-005453-4057qib7 15696 16 . . . cord-005453-4057qib7 15697 1 ATG ATG NNP cord-005453-4057qib7 15697 2 was be VBD cord-005453-4057qib7 15697 3 administered administer VBN cord-005453-4057qib7 15697 4 in in IN cord-005453-4057qib7 15697 5 56 56 CD cord-005453-4057qib7 15697 6 % % NN cord-005453-4057qib7 15697 7 and and CC cord-005453-4057qib7 15697 8 alemtuzumab alemtuzumab NNS cord-005453-4057qib7 15697 9 in in IN cord-005453-4057qib7 15697 10 9 9 CD cord-005453-4057qib7 15697 11 % % NN cord-005453-4057qib7 15697 12 of of IN cord-005453-4057qib7 15697 13 patients patient NNS cord-005453-4057qib7 15697 14 . . . cord-005453-4057qib7 15698 1 During during IN cord-005453-4057qib7 15698 2 follow follow NN cord-005453-4057qib7 15698 3 - - HYPH cord-005453-4057qib7 15698 4 up up NN cord-005453-4057qib7 15698 5 after after IN cord-005453-4057qib7 15698 6 alloHCT alloHCT NNP cord-005453-4057qib7 15698 7 776 776 CD cord-005453-4057qib7 15698 8 patients patient NNS cord-005453-4057qib7 15698 9 died die VBD cord-005453-4057qib7 15698 10 . . . cord-005453-4057qib7 15699 1 In in IN cord-005453-4057qib7 15699 2 univariable univariable JJ cord-005453-4057qib7 15699 3 and and CC cord-005453-4057qib7 15699 4 multivariable multivariable JJ cord-005453-4057qib7 15699 5 analyses analysis NNS cord-005453-4057qib7 15699 6 of of IN cord-005453-4057qib7 15699 7 the the DT cord-005453-4057qib7 15699 8 whole whole JJ cord-005453-4057qib7 15699 9 cohort cohort NN cord-005453-4057qib7 15699 10 , , , cord-005453-4057qib7 15699 11 overall overall JJ cord-005453-4057qib7 15699 12 survival survival NN cord-005453-4057qib7 15699 13 and and CC cord-005453-4057qib7 15699 14 the the DT cord-005453-4057qib7 15699 15 cumulative cumulative JJ cord-005453-4057qib7 15699 16 incidence incidence NN cord-005453-4057qib7 15699 17 of of IN cord-005453-4057qib7 15699 18 relapse relapse NN cord-005453-4057qib7 15699 19 of of IN cord-005453-4057qib7 15699 20 patients patient NNS cord-005453-4057qib7 15699 21 with with IN cord-005453-4057qib7 15699 22 KIRadvantageous KIRadvantageous NNP cord-005453-4057qib7 15699 23 versus versus IN cord-005453-4057qib7 15699 24 disadvantageous disadvantageous JJ cord-005453-4057qib7 15699 25 donors donor NNS cord-005453-4057qib7 15699 26 were be VBD cord-005453-4057qib7 15699 27 not not RB cord-005453-4057qib7 15699 28 statistically statistically RB cord-005453-4057qib7 15699 29 significantly significantly RB cord-005453-4057qib7 15699 30 different different JJ cord-005453-4057qib7 15699 31 . . . cord-005453-4057qib7 15700 1 We -PRON- PRP cord-005453-4057qib7 15700 2 could could MD cord-005453-4057qib7 15700 3 not not RB cord-005453-4057qib7 15700 4 replicate replicate VB cord-005453-4057qib7 15700 5 the the DT cord-005453-4057qib7 15700 6 pattern pattern NN cord-005453-4057qib7 15700 7 of of IN cord-005453-4057qib7 15700 8 outcomes outcome NNS cord-005453-4057qib7 15700 9 predicted predict VBN cord-005453-4057qib7 15700 10 by by IN cord-005453-4057qib7 15700 11 the the DT cord-005453-4057qib7 15700 12 KIR3DL1/ KIR3DL1/ NNP cord-005453-4057qib7 15700 13 Conclusions Conclusions NNPS cord-005453-4057qib7 15700 14 : : : cord-005453-4057qib7 15701 1 Relapse relapse VB cord-005453-4057qib7 15701 2 incidence incidence NN cord-005453-4057qib7 15701 3 and and CC cord-005453-4057qib7 15701 4 overall overall JJ cord-005453-4057qib7 15701 5 survival survival NN cord-005453-4057qib7 15701 6 after after IN cord-005453-4057qib7 15701 7 unrelated unrelated JJ cord-005453-4057qib7 15701 8 donor donor NN cord-005453-4057qib7 15701 9 alloHCT alloHCT NNP cord-005453-4057qib7 15701 10 could could MD cord-005453-4057qib7 15701 11 not not RB cord-005453-4057qib7 15701 12 be be VB cord-005453-4057qib7 15701 13 predicted predict VBN cord-005453-4057qib7 15701 14 using use VBG cord-005453-4057qib7 15701 15 the the DT cord-005453-4057qib7 15701 16 KIR3DL1 kir3dl1 CD cord-005453-4057qib7 15701 17 / / SYM cord-005453-4057qib7 15701 18 KIR2DS1-Receptor KIR2DS1-Receptor NNP cord-005453-4057qib7 15701 19 - - HYPH cord-005453-4057qib7 15701 20 Ligand Ligand NNP cord-005453-4057qib7 15701 21 model model NN cord-005453-4057qib7 15701 22 and and CC cord-005453-4057qib7 15701 23 centromeric centromeric NN cord-005453-4057qib7 15701 24 / / SYM cord-005453-4057qib7 15701 25 telomeric telomeric JJ cord-005453-4057qib7 15701 26 KIR KIR NNP cord-005453-4057qib7 15701 27 - - HYPH cord-005453-4057qib7 15701 28 motif motif NN cord-005453-4057qib7 15701 29 model model NN cord-005453-4057qib7 15701 30 in in IN cord-005453-4057qib7 15701 31 this this DT cord-005453-4057qib7 15701 32 large large JJ cord-005453-4057qib7 15701 33 cohort cohort NN cord-005453-4057qib7 15701 34 of of IN cord-005453-4057qib7 15701 35 patients patient NNS cord-005453-4057qib7 15701 36 with with IN cord-005453-4057qib7 15701 37 MDS MDS NNP cord-005453-4057qib7 15701 38 or or CC cord-005453-4057qib7 15701 39 secondary secondary JJ cord-005453-4057qib7 15701 40 AML AML NNP cord-005453-4057qib7 15701 41 . . . cord-005453-4057qib7 15702 1 This this DT cord-005453-4057qib7 15702 2 points point VBZ cord-005453-4057qib7 15702 3 at at IN cord-005453-4057qib7 15702 4 the the DT cord-005453-4057qib7 15702 5 possibility possibility NN cord-005453-4057qib7 15702 6 of of IN cord-005453-4057qib7 15702 7 interactions interaction NNS cord-005453-4057qib7 15702 8 between between IN cord-005453-4057qib7 15702 9 NK nk NN cord-005453-4057qib7 15702 10 - - HYPH cord-005453-4057qib7 15702 11 cell cell NN cord-005453-4057qib7 15702 12 mediated mediate VBD cord-005453-4057qib7 15702 13 alloreactivity alloreactivity NN cord-005453-4057qib7 15702 14 and and CC cord-005453-4057qib7 15702 15 disease disease NN cord-005453-4057qib7 15702 16 type type NN cord-005453-4057qib7 15702 17 or or CC cord-005453-4057qib7 15702 18 procedural procedural JJ cord-005453-4057qib7 15702 19 variations variation NNS cord-005453-4057qib7 15702 20 of of IN cord-005453-4057qib7 15702 21 alloHCT alloHCT NNP cord-005453-4057qib7 15702 22 . . . cord-005453-4057qib7 15703 1 Available available JJ cord-005453-4057qib7 15703 2 information information NN cord-005453-4057qib7 15703 3 on on IN cord-005453-4057qib7 15703 4 KIR KIR NNP cord-005453-4057qib7 15703 5 - - HYPH cord-005453-4057qib7 15703 6 genes gene NNS cord-005453-4057qib7 15703 7 , , , cord-005453-4057qib7 15703 8 which which WDT cord-005453-4057qib7 15703 9 have have VBP cord-005453-4057qib7 15703 10 been be VBN cord-005453-4057qib7 15703 11 sequenced sequence VBN cord-005453-4057qib7 15703 12 but but CC cord-005453-4057qib7 15703 13 not not RB cord-005453-4057qib7 15703 14 yet yet RB cord-005453-4057qib7 15703 15 analysed analyse VBN cord-005453-4057qib7 15703 16 , , , cord-005453-4057qib7 15703 17 will will MD cord-005453-4057qib7 15703 18 be be VB cord-005453-4057qib7 15703 19 investigated investigate VBN cord-005453-4057qib7 15703 20 in in IN cord-005453-4057qib7 15703 21 exploratory exploratory JJ cord-005453-4057qib7 15703 22 analyses analysis NNS cord-005453-4057qib7 15703 23 . . . cord-005453-4057qib7 15704 1 Disclosure disclosure NN cord-005453-4057qib7 15704 2 : : : cord-005453-4057qib7 15705 1 The the DT cord-005453-4057qib7 15705 2 authors author NNS cord-005453-4057qib7 15705 3 have have VBP cord-005453-4057qib7 15705 4 nothing nothing NN cord-005453-4057qib7 15705 5 to to TO cord-005453-4057qib7 15705 6 disclose disclose VB cord-005453-4057qib7 15705 7 In in IN cord-005453-4057qib7 15705 8 the the DT cord-005453-4057qib7 15705 9 absence absence NN cord-005453-4057qib7 15705 10 of of IN cord-005453-4057qib7 15705 11 an an DT cord-005453-4057qib7 15705 12 alternative alternative JJ cord-005453-4057qib7 15705 13 donor donor NN cord-005453-4057qib7 15705 14 , , , cord-005453-4057qib7 15705 15 it -PRON- PRP cord-005453-4057qib7 15705 16 is be VBZ cord-005453-4057qib7 15705 17 recommended recommend VBN cord-005453-4057qib7 15705 18 that that IN cord-005453-4057qib7 15705 19 patients patient NNS cord-005453-4057qib7 15705 20 undergo undergo VBP cord-005453-4057qib7 15705 21 desensitization desensitization NN cord-005453-4057qib7 15705 22 therapy therapy NN cord-005453-4057qib7 15705 23 , , , cord-005453-4057qib7 15705 24 especially especially RB cord-005453-4057qib7 15705 25 with with IN cord-005453-4057qib7 15705 26 high high JJ cord-005453-4057qib7 15705 27 DSA DSA NNP cord-005453-4057qib7 15705 28 levels level NNS cord-005453-4057qib7 15705 29 ( ( -LRB- cord-005453-4057qib7 15705 30 > > NFP cord-005453-4057qib7 15705 31 5,000 5,000 CD cord-005453-4057qib7 15705 32 MFI MFI NNP cord-005453-4057qib7 15705 33 ) ) -RRB- cord-005453-4057qib7 15705 34 . . . cord-005453-4057qib7 15706 1 The the DT cord-005453-4057qib7 15706 2 aim aim NN cord-005453-4057qib7 15706 3 of of IN cord-005453-4057qib7 15706 4 this this DT cord-005453-4057qib7 15706 5 study study NN cord-005453-4057qib7 15706 6 is be VBZ cord-005453-4057qib7 15706 7 to to TO cord-005453-4057qib7 15706 8 analyze analyze VB cord-005453-4057qib7 15706 9 the the DT cord-005453-4057qib7 15706 10 impact impact NN cord-005453-4057qib7 15706 11 of of IN cord-005453-4057qib7 15706 12 DSA DSA NNP cord-005453-4057qib7 15706 13 on on IN cord-005453-4057qib7 15706 14 risk risk NN cord-005453-4057qib7 15706 15 of of IN cord-005453-4057qib7 15706 16 GF GF NNP cord-005453-4057qib7 15706 17 and and CC cord-005453-4057qib7 15706 18 poor poor JJ cord-005453-4057qib7 15706 19 graft graft NN cord-005453-4057qib7 15706 20 function function NN cord-005453-4057qib7 15706 21 ( ( -LRB- cord-005453-4057qib7 15706 22 PGF PGF NNP cord-005453-4057qib7 15706 23 ) ) -RRB- cord-005453-4057qib7 15706 24 , , , cord-005453-4057qib7 15706 25 and and CC cord-005453-4057qib7 15706 26 on on IN cord-005453-4057qib7 15706 27 major major JJ cord-005453-4057qib7 15706 28 outcomes outcome NNS cord-005453-4057qib7 15706 29 in in IN cord-005453-4057qib7 15706 30 a a DT cord-005453-4057qib7 15706 31 consecutive consecutive JJ cord-005453-4057qib7 15706 32 cohort cohort NN cord-005453-4057qib7 15706 33 of of IN cord-005453-4057qib7 15706 34 patients patient NNS cord-005453-4057qib7 15706 35 who who WP cord-005453-4057qib7 15706 36 were be VBD cord-005453-4057qib7 15706 37 systematically systematically RB cord-005453-4057qib7 15706 38 screened screen VBN cord-005453-4057qib7 15706 39 for for IN cord-005453-4057qib7 15706 40 DSA DSA NNP cord-005453-4057qib7 15706 41 before before IN cord-005453-4057qib7 15706 42 Haplo Haplo NNP cord-005453-4057qib7 15706 43 - - HYPH cord-005453-4057qib7 15706 44 SCT SCT NNP cord-005453-4057qib7 15706 45 . . . cord-005453-4057qib7 15707 1 Methods method NNS cord-005453-4057qib7 15707 2 : : : cord-005453-4057qib7 15707 3 141 141 CD cord-005453-4057qib7 15707 4 consecutive consecutive JJ cord-005453-4057qib7 15707 5 patients patient NNS cord-005453-4057qib7 15707 6 were be VBD cord-005453-4057qib7 15707 7 candidates candidate NNS cord-005453-4057qib7 15707 8 for for IN cord-005453-4057qib7 15707 9 unmanipulated unmanipulated JJ cord-005453-4057qib7 15707 10 Haplo Haplo NNP cord-005453-4057qib7 15707 11 - - HYPH cord-005453-4057qib7 15707 12 SCT SCT NNP cord-005453-4057qib7 15707 13 with with IN cord-005453-4057qib7 15707 14 post post JJ cord-005453-4057qib7 15707 15 - - JJ cord-005453-4057qib7 15707 16 transplant transplant NN cord-005453-4057qib7 15707 17 Cyclophosphamide Cyclophosphamide NNP cord-005453-4057qib7 15707 18 ( ( -LRB- cord-005453-4057qib7 15707 19 PT PT NNP cord-005453-4057qib7 15707 20 - - HYPH cord-005453-4057qib7 15707 21 Cy Cy NNP cord-005453-4057qib7 15707 22 ) ) -RRB- cord-005453-4057qib7 15707 23 at at IN cord-005453-4057qib7 15707 24 our -PRON- PRP$ cord-005453-4057qib7 15707 25 center center NN cord-005453-4057qib7 15707 26 from from IN cord-005453-4057qib7 15707 27 January January NNP cord-005453-4057qib7 15707 28 2012 2012 CD cord-005453-4057qib7 15707 29 to to IN cord-005453-4057qib7 15707 30 January January NNP cord-005453-4057qib7 15707 31 2018 2018 CD cord-005453-4057qib7 15707 32 and and CC cord-005453-4057qib7 15707 33 135 135 CD cord-005453-4057qib7 15707 34 were be VBD cord-005453-4057qib7 15707 35 analyzed analyze VBN cord-005453-4057qib7 15707 36 for for IN cord-005453-4057qib7 15707 37 the the DT cord-005453-4057qib7 15707 38 presence presence NN cord-005453-4057qib7 15707 39 of of IN cord-005453-4057qib7 15707 40 HLA HLA NNP cord-005453-4057qib7 15707 41 antibodies antibody NNS cord-005453-4057qib7 15707 42 . . . cord-005453-4057qib7 15708 1 Results result NNS cord-005453-4057qib7 15708 2 : : : cord-005453-4057qib7 15708 3 134 134 CD cord-005453-4057qib7 15708 4 patients patient NNS cord-005453-4057qib7 15708 5 underwent undergo VBD cord-005453-4057qib7 15708 6 haplo haplo NNP cord-005453-4057qib7 15708 7 - - HYPH cord-005453-4057qib7 15708 8 SCT SCT NNP cord-005453-4057qib7 15708 9 . . . cord-005453-4057qib7 15709 1 HLA HLA NNP cord-005453-4057qib7 15709 2 antibodies antibody NNS cord-005453-4057qib7 15709 3 were be VBD cord-005453-4057qib7 15709 4 detected detect VBN cord-005453-4057qib7 15709 5 in in IN cord-005453-4057qib7 15709 6 40 40 CD cord-005453-4057qib7 15709 7 patients,19 patients,19 CD cord-005453-4057qib7 15709 8 of of IN cord-005453-4057qib7 15709 9 them -PRON- PRP cord-005453-4057qib7 15709 10 were be VBD cord-005453-4057qib7 15709 11 DSA DSA NNP cord-005453-4057qib7 15709 12 , , , cord-005453-4057qib7 15709 13 while while IN cord-005453-4057qib7 15709 14 21 21 CD cord-005453-4057qib7 15709 15 were be VBD cord-005453-4057qib7 15709 16 non non JJ cord-005453-4057qib7 15709 17 - - JJ cord-005453-4057qib7 15709 18 DSA dsa JJ cord-005453-4057qib7 15709 19 ( ( -LRB- cord-005453-4057qib7 15709 20 NDSA NDSA NNP cord-005453-4057qib7 15709 21 ) ) -RRB- cord-005453-4057qib7 15709 22 . . . cord-005453-4057qib7 15710 1 10 10 CD cord-005453-4057qib7 15710 2 patients patient NNS cord-005453-4057qib7 15710 3 out out IN cord-005453-4057qib7 15710 4 of of IN cord-005453-4057qib7 15710 5 19 19 CD cord-005453-4057qib7 15710 6 with with IN cord-005453-4057qib7 15710 7 DSA DSA NNP cord-005453-4057qib7 15710 8 were be VBD cord-005453-4057qib7 15710 9 transplanted transplant VBN cord-005453-4057qib7 15710 10 using use VBG cord-005453-4057qib7 15710 11 the the DT cord-005453-4057qib7 15710 12 same same JJ cord-005453-4057qib7 15710 13 donor donor NN cord-005453-4057qib7 15710 14 ; ; : cord-005453-4057qib7 15710 15 2 2 CD cord-005453-4057qib7 15710 16 underwent undergo VBD cord-005453-4057qib7 15710 17 a a DT cord-005453-4057qib7 15710 18 desensitization desensitization NN cord-005453-4057qib7 15710 19 program program NN cord-005453-4057qib7 15710 20 before before IN cord-005453-4057qib7 15710 21 transplant transplant NN cord-005453-4057qib7 15710 22 . . . cord-005453-4057qib7 15711 1 Background background NN cord-005453-4057qib7 15711 2 : : : cord-005453-4057qib7 15712 1 A a DT cord-005453-4057qib7 15712 2 recent recent JJ cord-005453-4057qib7 15712 3 study study NN cord-005453-4057qib7 15712 4 from from IN cord-005453-4057qib7 15712 5 EBMT EBMT NNP cord-005453-4057qib7 15712 6 comparing compare VBG cord-005453-4057qib7 15712 7 matched match VBN cord-005453-4057qib7 15712 8 sibling sibling NN cord-005453-4057qib7 15712 9 ( ( -LRB- cord-005453-4057qib7 15712 10 MSD MSD NNP cord-005453-4057qib7 15712 11 ) ) -RRB- cord-005453-4057qib7 15712 12 versus versus IN cord-005453-4057qib7 15712 13 haploidentical haploidentical JJ cord-005453-4057qib7 15712 14 donors donor NNS cord-005453-4057qib7 15712 15 transplantations transplantation NNS cord-005453-4057qib7 15712 16 , , , cord-005453-4057qib7 15712 17 showed show VBD cord-005453-4057qib7 15712 18 better well JJR cord-005453-4057qib7 15712 19 outcome outcome NN cord-005453-4057qib7 15712 20 with with IN cord-005453-4057qib7 15712 21 MSD MSD NNP cord-005453-4057qib7 15712 22 in in IN cord-005453-4057qib7 15712 23 adult adult NN cord-005453-4057qib7 15712 24 patients patient NNS cord-005453-4057qib7 15712 25 with with IN cord-005453-4057qib7 15712 26 intermediate intermediate JJ cord-005453-4057qib7 15712 27 risk risk NN cord-005453-4057qib7 15712 28 AML AML NNP cord-005453-4057qib7 15712 29 in in IN cord-005453-4057qib7 15712 30 first first JJ cord-005453-4057qib7 15712 31 remission remission NN cord-005453-4057qib7 15712 32 ( ( -LRB- cord-005453-4057qib7 15712 33 CR1 CR1 NNP cord-005453-4057qib7 15712 34 ) ) -RRB- cord-005453-4057qib7 15712 35 . . . cord-005453-4057qib7 15713 1 However however RB cord-005453-4057qib7 15713 2 , , , cord-005453-4057qib7 15713 3 a a DT cord-005453-4057qib7 15713 4 female female JJ cord-005453-4057qib7 15713 5 donor donor NN cord-005453-4057qib7 15713 6 to to IN cord-005453-4057qib7 15713 7 a a DT cord-005453-4057qib7 15713 8 male male JJ cord-005453-4057qib7 15713 9 recipient recipient NN cord-005453-4057qib7 15713 10 transplant transplant NN cord-005453-4057qib7 15713 11 combination combination NN cord-005453-4057qib7 15713 12 is be VBZ cord-005453-4057qib7 15713 13 a a DT cord-005453-4057qib7 15713 14 poor poor JJ cord-005453-4057qib7 15713 15 prognostic prognostic JJ cord-005453-4057qib7 15713 16 factor factor NN cord-005453-4057qib7 15713 17 and and CC cord-005453-4057qib7 15713 18 this this DT cord-005453-4057qib7 15713 19 study study NN cord-005453-4057qib7 15713 20 did do VBD cord-005453-4057qib7 15713 21 not not RB cord-005453-4057qib7 15713 22 address address VB cord-005453-4057qib7 15713 23 the the DT cord-005453-4057qib7 15713 24 question question NN cord-005453-4057qib7 15713 25 whether whether IN cord-005453-4057qib7 15713 26 in in IN cord-005453-4057qib7 15713 27 this this DT cord-005453-4057qib7 15713 28 situation situation NN cord-005453-4057qib7 15713 29 , , , cord-005453-4057qib7 15713 30 a a DT cord-005453-4057qib7 15713 31 haploidentical haploidentical JJ cord-005453-4057qib7 15713 32 donor donor NN cord-005453-4057qib7 15713 33 transplant transplant NN cord-005453-4057qib7 15713 34 might may MD cord-005453-4057qib7 15713 35 do do VB cord-005453-4057qib7 15713 36 better well RBR cord-005453-4057qib7 15713 37 . . . cord-005453-4057qib7 15714 1 The the DT cord-005453-4057qib7 15714 2 present present JJ cord-005453-4057qib7 15714 3 study study NN cord-005453-4057qib7 15714 4 compared compare VBD cord-005453-4057qib7 15714 5 the the DT cord-005453-4057qib7 15714 6 outcomes outcome NNS cord-005453-4057qib7 15714 7 of of IN cord-005453-4057qib7 15714 8 allografted allografte VBN cord-005453-4057qib7 15714 9 male male JJ cord-005453-4057qib7 15714 10 patients patient NNS cord-005453-4057qib7 15714 11 according accord VBG cord-005453-4057qib7 15714 12 to to IN cord-005453-4057qib7 15714 13 whether whether IN cord-005453-4057qib7 15714 14 they -PRON- PRP cord-005453-4057qib7 15714 15 received receive VBD cord-005453-4057qib7 15714 16 stem stem NN cord-005453-4057qib7 15714 17 cells cell NNS cord-005453-4057qib7 15714 18 from from IN cord-005453-4057qib7 15714 19 a a DT cord-005453-4057qib7 15714 20 female female JJ cord-005453-4057qib7 15714 21 MSD msd NN cord-005453-4057qib7 15714 22 or or CC cord-005453-4057qib7 15714 23 a a DT cord-005453-4057qib7 15714 24 haploidentical haploidentical JJ cord-005453-4057qib7 15714 25 donor donor NN cord-005453-4057qib7 15714 26 , , , cord-005453-4057qib7 15714 27 in in IN cord-005453-4057qib7 15714 28 the the DT cord-005453-4057qib7 15714 29 intermediate intermediate JJ cord-005453-4057qib7 15714 30 and and CC cord-005453-4057qib7 15714 31 high high JJ cord-005453-4057qib7 15714 32 risk risk NN cord-005453-4057qib7 15714 33 cytogenetics cytogenetic NNS cord-005453-4057qib7 15714 34 groups group NNS cord-005453-4057qib7 15714 35 ( ( -LRB- cord-005453-4057qib7 15714 36 MRC MRC NNP cord-005453-4057qib7 15714 37 classification).Methods classification).method NNS cord-005453-4057qib7 15714 38 : : : cord-005453-4057qib7 15714 39 The the DT cord-005453-4057qib7 15714 40 study study NN cord-005453-4057qib7 15714 41 included include VBD cord-005453-4057qib7 15714 42 1066 1066 CD cord-005453-4057qib7 15714 43 male male JJ cord-005453-4057qib7 15714 44 patients patient NNS cord-005453-4057qib7 15714 45 with with IN cord-005453-4057qib7 15714 46 cytogenetics cytogenetic NNS cord-005453-4057qib7 15714 47 transplanted transplant VBN cord-005453-4057qib7 15714 48 between between IN cord-005453-4057qib7 15714 49 January January NNP cord-005453-4057qib7 15714 50 2007 2007 CD cord-005453-4057qib7 15714 51 and and CC cord-005453-4057qib7 15714 52 June June NNP cord-005453-4057qib7 15714 53 2017 2017 CD cord-005453-4057qib7 15714 54 and and CC cord-005453-4057qib7 15714 55 reported report VBD cord-005453-4057qib7 15714 56 to to IN cord-005453-4057qib7 15714 57 EBMT EBMT NNP cord-005453-4057qib7 15714 58 . . . cord-005453-4057qib7 15715 1 834 834 CD cord-005453-4057qib7 15715 2 received receive VBD cord-005453-4057qib7 15715 3 stem stem NN cord-005453-4057qib7 15715 4 cells cell NNS cord-005453-4057qib7 15715 5 from from IN cord-005453-4057qib7 15715 6 a a DT cord-005453-4057qib7 15715 7 MSD MSD NNP cord-005453-4057qib7 15715 8 female female JJ cord-005453-4057qib7 15715 9 donor donor NN cord-005453-4057qib7 15715 10 and and CC cord-005453-4057qib7 15715 11 232 232 CD cord-005453-4057qib7 15715 12 from from IN cord-005453-4057qib7 15715 13 a a DT cord-005453-4057qib7 15715 14 haploidentical haploidentical JJ cord-005453-4057qib7 15715 15 donor donor NN cord-005453-4057qib7 15715 16 ( ( -LRB- cord-005453-4057qib7 15715 17 133 133 CD cord-005453-4057qib7 15715 18 male male NN cord-005453-4057qib7 15715 19 and and CC cord-005453-4057qib7 15715 20 99 99 CD cord-005453-4057qib7 15715 21 female female NN cord-005453-4057qib7 15715 22 ) ) -RRB- cord-005453-4057qib7 15715 23 . . . cord-005453-4057qib7 15716 1 The the DT cord-005453-4057qib7 15716 2 follow follow NN cord-005453-4057qib7 15716 3 up up RP cord-005453-4057qib7 15716 4 was be VBD cord-005453-4057qib7 15716 5 25 25 CD cord-005453-4057qib7 15716 6 months month NNS cord-005453-4057qib7 15716 7 ( ( -LRB- cord-005453-4057qib7 15716 8 12 12 CD cord-005453-4057qib7 15716 9 - - SYM cord-005453-4057qib7 15716 10 62 62 CD cord-005453-4057qib7 15716 11 ) ) -RRB- cord-005453-4057qib7 15716 12 . . . cord-005453-4057qib7 15717 1 We -PRON- PRP cord-005453-4057qib7 15717 2 studied study VBD cord-005453-4057qib7 15717 3 separately separately RB cord-005453-4057qib7 15717 4 intermediate intermediate JJ cord-005453-4057qib7 15717 5 and and CC cord-005453-4057qib7 15717 6 high high JJ cord-005453-4057qib7 15717 7 risk risk NN cord-005453-4057qib7 15717 8 patients patient NNS cord-005453-4057qib7 15717 9 . . . cord-005453-4057qib7 15718 1 Multivariate multivariate JJ cord-005453-4057qib7 15718 2 analysis analysis NN cord-005453-4057qib7 15718 3 was be VBD cord-005453-4057qib7 15718 4 adjusted adjust VBN cord-005453-4057qib7 15718 5 on on IN cord-005453-4057qib7 15718 6 factors factor NNS cord-005453-4057qib7 15718 7 differing differ VBG cord-005453-4057qib7 15718 8 significantly significantly RB cord-005453-4057qib7 15718 9 between between IN cord-005453-4057qib7 15718 10 the the DT cord-005453-4057qib7 15718 11 2 2 CD cord-005453-4057qib7 15718 12 groups group NNS cord-005453-4057qib7 15718 13 . . . cord-005453-4057qib7 15719 1 Results result NNS cord-005453-4057qib7 15719 2 : : : cord-005453-4057qib7 15720 1 1-Intermediate 1-intermediate CD cord-005453-4057qib7 15720 2 risk risk NN cord-005453-4057qib7 15720 3 group group NN cord-005453-4057qib7 15720 4 : : : cord-005453-4057qib7 15720 5 638 638 CD cord-005453-4057qib7 15720 6 male male JJ cord-005453-4057qib7 15720 7 patients patient NNS cord-005453-4057qib7 15720 8 received receive VBD cord-005453-4057qib7 15720 9 a a DT cord-005453-4057qib7 15720 10 female female JJ cord-005453-4057qib7 15720 11 MSD msd NN cord-005453-4057qib7 15720 12 and and CC cord-005453-4057qib7 15720 13 160 160 CD cord-005453-4057qib7 15720 14 a a DT cord-005453-4057qib7 15720 15 haploidentical haploidentical JJ cord-005453-4057qib7 15720 16 transplant transplant NN cord-005453-4057qib7 15720 17 . . . cord-005453-4057qib7 15721 1 The the DT cord-005453-4057qib7 15721 2 distribution distribution NN cord-005453-4057qib7 15721 3 of of IN cord-005453-4057qib7 15721 4 group group NN cord-005453-4057qib7 15721 5 characteristics characteristic NNS cord-005453-4057qib7 15721 6 was be VBD cord-005453-4057qib7 15721 7 even even RB cord-005453-4057qib7 15721 8 except except IN cord-005453-4057qib7 15722 1 that that IN cord-005453-4057qib7 15722 2 in in IN cord-005453-4057qib7 15722 3 the the DT cord-005453-4057qib7 15722 4 haploidentical haploidentical JJ cord-005453-4057qib7 15722 5 transplant transplant NN cord-005453-4057qib7 15722 6 group group NN cord-005453-4057qib7 15722 7 , , , cord-005453-4057qib7 15722 8 donors donor NNS cord-005453-4057qib7 15722 9 were be VBD cord-005453-4057qib7 15722 10 younger young JJR cord-005453-4057qib7 15723 1 ( ( -LRB- cord-005453-4057qib7 15723 2 39 39 CD cord-005453-4057qib7 15723 3 y y NN cord-005453-4057qib7 15723 4 versus versus IN cord-005453-4057qib7 15723 5 51 51 CD cord-005453-4057qib7 15723 6 ; ; : cord-005453-4057qib7 15723 7 p p NN cord-005453-4057qib7 15723 8 < < XX cord-005453-4057qib7 15723 9 0.0001 0.0001 CD cord-005453-4057qib7 15723 10 ) ) -RRB- cord-005453-4057qib7 15723 11 , , , cord-005453-4057qib7 15723 12 marrow marrow NN cord-005453-4057qib7 15723 13 was be VBD cord-005453-4057qib7 15723 14 more more RBR cord-005453-4057qib7 15723 15 frequently frequently RB cord-005453-4057qib7 15723 16 used use VBN cord-005453-4057qib7 15723 17 ( ( -LRB- cord-005453-4057qib7 15723 18 45 45 CD cord-005453-4057qib7 15723 19 % % NN cord-005453-4057qib7 15723 20 versus versus IN cord-005453-4057qib7 15723 21 17 17 CD cord-005453-4057qib7 15723 22 % % NN cord-005453-4057qib7 15723 23 , , , cord-005453-4057qib7 15723 24 p p NN cord-005453-4057qib7 15723 25 < < XX cord-005453-4057qib7 15723 26 0.0001 0.0001 CD cord-005453-4057qib7 15723 27 ) ) -RRB- cord-005453-4057qib7 15723 28 and and CC cord-005453-4057qib7 15723 29 the the DT cord-005453-4057qib7 15723 30 interval interval NN cord-005453-4057qib7 15723 31 from from IN cord-005453-4057qib7 15723 32 diagnosis diagnosis NN cord-005453-4057qib7 15723 33 to to IN cord-005453-4057qib7 15723 34 transplant transplant NN cord-005453-4057qib7 15723 35 was be VBD cord-005453-4057qib7 15723 36 longer long JJR cord-005453-4057qib7 15723 37 ( ( -LRB- cord-005453-4057qib7 15723 38 5.4 5.4 CD cord-005453-4057qib7 15723 39 versus versus IN cord-005453-4057qib7 15723 40 4.5 4.5 CD cord-005453-4057qib7 15723 41 months month NNS cord-005453-4057qib7 15723 42 , , , cord-005453-4057qib7 15723 43 p p NN cord-005453-4057qib7 15723 44 < < XX cord-005453-4057qib7 15723 45 0.0001 0.0001 CD cord-005453-4057qib7 15723 46 ) ) -RRB- cord-005453-4057qib7 15723 47 . . . cord-005453-4057qib7 15724 1 By by IN cord-005453-4057qib7 15724 2 univariate univariate JJ cord-005453-4057qib7 15724 3 analysis analysis NN cord-005453-4057qib7 15724 4 at at IN cord-005453-4057qib7 15724 5 two two CD cord-005453-4057qib7 15724 6 years year NNS cord-005453-4057qib7 15724 7 post post NN cord-005453-4057qib7 15724 8 transplant transplant NN cord-005453-4057qib7 15724 9 , , , cord-005453-4057qib7 15724 10 cumulative cumulative JJ cord-005453-4057qib7 15724 11 incidence incidence NN cord-005453-4057qib7 15724 12 ( ( -LRB- cord-005453-4057qib7 15724 13 CI CI NNP cord-005453-4057qib7 15724 14 ) ) -RRB- cord-005453-4057qib7 15724 15 of of IN cord-005453-4057qib7 15724 16 NRM NRM NNP cord-005453-4057qib7 15724 17 post post NN cord-005453-4057qib7 15724 18 haplo haplo NN cord-005453-4057qib7 15724 19 was be VBD cord-005453-4057qib7 15724 20 higher high JJR cord-005453-4057qib7 15724 21 ( ( -LRB- cord-005453-4057qib7 15724 22 26 26 CD cord-005453-4057qib7 15724 23 % % NN cord-005453-4057qib7 15724 24 versus versus IN cord-005453-4057qib7 15724 25 15 15 CD cord-005453-4057qib7 15724 26 % % NN cord-005453-4057qib7 15724 27 , , , cord-005453-4057qib7 15724 28 p=0.002 p=0.002 NNP cord-005453-4057qib7 15724 29 ) ) -RRB- cord-005453-4057qib7 15724 30 and and CC cord-005453-4057qib7 15724 31 CI CI NNP cord-005453-4057qib7 15724 32 of of IN cord-005453-4057qib7 15724 33 extensive extensive JJ cord-005453-4057qib7 15724 34 chronic chronic JJ cord-005453-4057qib7 15724 35 GVH GVH NNP cord-005453-4057qib7 15724 36 lower lower RBR cord-005453-4057qib7 15724 37 ( ( -LRB- cord-005453-4057qib7 15724 38 14 14 CD cord-005453-4057qib7 15724 39 % % NN cord-005453-4057qib7 15724 40 versus versus IN cord-005453-4057qib7 15724 41 27 27 CD cord-005453-4057qib7 15724 42 % % NN cord-005453-4057qib7 15724 43 ; ; : cord-005453-4057qib7 15724 44 p=0.002 p=0.002 NNP cord-005453-4057qib7 15724 45 ) ) -RRB- cord-005453-4057qib7 15724 46 . . . cord-005453-4057qib7 15725 1 LFS LFS NNP cord-005453-4057qib7 15725 2 post post NN cord-005453-4057qib7 15725 3 MSD MSD NNP cord-005453-4057qib7 15725 4 and and CC cord-005453-4057qib7 15725 5 post post NN cord-005453-4057qib7 15725 6 haplo haplo NNP cord-005453-4057qib7 15725 7 were be VBD cord-005453-4057qib7 15725 8 64 64 CD cord-005453-4057qib7 15725 9 % % NN cord-005453-4057qib7 15725 10 and and CC cord-005453-4057qib7 15725 11 51 51 CD cord-005453-4057qib7 15725 12 % % NN cord-005453-4057qib7 15725 13 ( ( -LRB- cord-005453-4057qib7 15725 14 p=0.03 p=0.03 NNP cord-005453-4057qib7 15725 15 ) ) -RRB- cord-005453-4057qib7 15725 16 , , , cord-005453-4057qib7 15725 17 OS OS NNP cord-005453-4057qib7 15725 18 69 69 CD cord-005453-4057qib7 15725 19 % % NN cord-005453-4057qib7 15725 20 and and CC cord-005453-4057qib7 15725 21 60 60 CD cord-005453-4057qib7 15725 22 % % NN cord-005453-4057qib7 15725 23 ( ( -LRB- cord-005453-4057qib7 15725 24 NS NS NNP cord-005453-4057qib7 15725 25 ) ) -RRB- cord-005453-4057qib7 15725 26 , , , cord-005453-4057qib7 15725 27 GRFS GRFS NNP cord-005453-4057qib7 15725 28 ( ( -LRB- cord-005453-4057qib7 15725 29 43 43 CD cord-005453-4057qib7 15725 30 % % NN cord-005453-4057qib7 15725 31 and and CC cord-005453-4057qib7 15725 32 43 43 CD cord-005453-4057qib7 15725 33 % % NN cord-005453-4057qib7 15725 34 ) ) -RRB- cord-005453-4057qib7 15725 35 . . . cord-005453-4057qib7 15726 1 By by IN cord-005453-4057qib7 15726 2 multivariate multivariate JJ cord-005453-4057qib7 15726 3 analyses analysis NNS cord-005453-4057qib7 15726 4 the the DT cord-005453-4057qib7 15726 5 only only JJ cord-005453-4057qib7 15726 6 significant significant JJ cord-005453-4057qib7 15726 7 poor poor JJ cord-005453-4057qib7 15726 8 risk risk NN cord-005453-4057qib7 15726 9 factors factor NNS cord-005453-4057qib7 15726 10 were be VBD cord-005453-4057qib7 15726 11 the the DT cord-005453-4057qib7 15726 12 haplo haplo NN cord-005453-4057qib7 15726 13 - - HYPH cord-005453-4057qib7 15726 14 identical identical JJ cord-005453-4057qib7 15726 15 transplant transplant NN cord-005453-4057qib7 15726 16 for for IN cord-005453-4057qib7 15726 17 NRM NRM NNP cord-005453-4057qib7 15726 18 ( ( -LRB- cord-005453-4057qib7 15726 19 HR HR NNP cord-005453-4057qib7 15726 20 : : : cord-005453-4057qib7 15726 21 1.7 1.7 CD cord-005453-4057qib7 15726 22 ( ( -LRB- cord-005453-4057qib7 15726 23 1.1 1.1 CD cord-005453-4057qib7 15726 24 - - HYPH cord-005453-4057qib7 15726 25 2 2 CD cord-005453-4057qib7 15726 26 - - SYM cord-005453-4057qib7 15726 27 61 61 CD cord-005453-4057qib7 15726 28 ) ) -RRB- cord-005453-4057qib7 15726 29 ) ) -RRB- cord-005453-4057qib7 15726 30 and and CC cord-005453-4057qib7 15726 31 the the DT cord-005453-4057qib7 15726 32 patient patient JJ cord-005453-4057qib7 15726 33 age age NN cord-005453-4057qib7 15726 34 for for IN cord-005453-4057qib7 15726 35 OS OS NNP cord-005453-4057qib7 15726 36 ( ( -LRB- cord-005453-4057qib7 15726 37 HR hr NN cord-005453-4057qib7 15726 38 : : : cord-005453-4057qib7 15726 39 1.15 1.15 CD cord-005453-4057qib7 15726 40 ( ( -LRB- cord-005453-4057qib7 15726 41 1.02 1.02 CD cord-005453-4057qib7 15726 42 - - SYM cord-005453-4057qib7 15726 43 1.28 1.28 CD cord-005453-4057qib7 15726 44 ; ; : cord-005453-4057qib7 15726 45 p=0.02 p=0.02 NN cord-005453-4057qib7 15726 46 ) ) -RRB- cord-005453-4057qib7 15726 47 . . . cord-005453-4057qib7 15727 1 Haploidentical haploidentical JJ cord-005453-4057qib7 15727 2 transplantation transplantation NN cord-005453-4057qib7 15727 3 resulted result VBD cord-005453-4057qib7 15727 4 in in IN cord-005453-4057qib7 15727 5 less less JJR cord-005453-4057qib7 15727 6 chronic chronic JJ cord-005453-4057qib7 15727 7 GVHD GVHD NNP cord-005453-4057qib7 15727 8 ( ( -LRB- cord-005453-4057qib7 15727 9 HR hr NN cord-005453-4057qib7 15727 10 : : : cord-005453-4057qib7 15727 11 0.43 0.43 CD cord-005453-4057qib7 15727 12 ( ( -LRB- cord-005453-4057qib7 15727 13 0.29 0.29 CD cord-005453-4057qib7 15727 14 - - SYM cord-005453-4057qib7 15727 15 0.64 0.64 CD cord-005453-4057qib7 15727 16 ) ) -RRB- cord-005453-4057qib7 15727 17 ; ; : cord-005453-4057qib7 15727 18 p p NN cord-005453-4057qib7 15727 19 < < XX cord-005453-4057qib7 15727 20 10 10 CD cord-005453-4057qib7 15727 21 -4 -4 CD cord-005453-4057qib7 15727 22 ) ) -RRB- cord-005453-4057qib7 15727 23 , , , cord-005453-4057qib7 15727 24 but but CC cord-005453-4057qib7 15727 25 a a DT cord-005453-4057qib7 15727 26 lower low JJR cord-005453-4057qib7 15727 27 LFS lfs NN cord-005453-4057qib7 15727 28 ( ( -LRB- cord-005453-4057qib7 15727 29 HR hr NN cord-005453-4057qib7 15727 30 : : : cord-005453-4057qib7 15727 31 1.7 1.7 CD cord-005453-4057qib7 15727 32 ( ( -LRB- cord-005453-4057qib7 15727 33 1.1 1.1 CD cord-005453-4057qib7 15727 34 - - SYM cord-005453-4057qib7 15727 35 2.61 2.61 CD cord-005453-4057qib7 15727 36 ) ) -RRB- cord-005453-4057qib7 15727 37 ; ; : cord-005453-4057qib7 15727 38 p=0.04 p=0.04 NNP cord-005453-4057qib7 15727 39 ) ) -RRB- cord-005453-4057qib7 15727 40 . . . cord-005453-4057qib7 15728 1 2-High 2-high CD cord-005453-4057qib7 15728 2 risk risk NN cord-005453-4057qib7 15728 3 group group NN cord-005453-4057qib7 15728 4 : : : cord-005453-4057qib7 15728 5 196 196 CD cord-005453-4057qib7 15728 6 male male JJ cord-005453-4057qib7 15728 7 patients patient NNS cord-005453-4057qib7 15728 8 received receive VBD cord-005453-4057qib7 15728 9 a a DT cord-005453-4057qib7 15728 10 female female JJ cord-005453-4057qib7 15728 11 MSD msd NN cord-005453-4057qib7 15728 12 and and CC cord-005453-4057qib7 15728 13 72 72 CD cord-005453-4057qib7 15728 14 a a DT cord-005453-4057qib7 15728 15 haploidentical haploidentical JJ cord-005453-4057qib7 15728 16 transplant transplant NN cord-005453-4057qib7 15728 17 . . . cord-005453-4057qib7 15729 1 In in IN cord-005453-4057qib7 15729 2 the the DT cord-005453-4057qib7 15729 3 haploidentical haploidentical JJ cord-005453-4057qib7 15729 4 group group NN cord-005453-4057qib7 15729 5 , , , cord-005453-4057qib7 15729 6 donors donor NNS cord-005453-4057qib7 15729 7 were be VBD cord-005453-4057qib7 15729 8 younger young JJR cord-005453-4057qib7 15729 9 ( ( -LRB- cord-005453-4057qib7 15729 10 38 38 CD cord-005453-4057qib7 15729 11 y y NN cord-005453-4057qib7 15729 12 versus versus IN cord-005453-4057qib7 15729 13 54 54 CD cord-005453-4057qib7 15729 14 ; ; : cord-005453-4057qib7 15729 15 p p NN cord-005453-4057qib7 15729 16 < < XX cord-005453-4057qib7 15729 17 0.0001 0.0001 CD cord-005453-4057qib7 15729 18 ) ) -RRB- cord-005453-4057qib7 15729 19 , , , cord-005453-4057qib7 15729 20 marrow marrow NN cord-005453-4057qib7 15729 21 was be VBD cord-005453-4057qib7 15729 22 more more RBR cord-005453-4057qib7 15729 23 frequently frequently RB cord-005453-4057qib7 15729 24 used use VBN cord-005453-4057qib7 15729 25 ( ( -LRB- cord-005453-4057qib7 15729 26 42 42 CD cord-005453-4057qib7 15729 27 % % NN cord-005453-4057qib7 15729 28 versus versus IN cord-005453-4057qib7 15729 29 11 11 CD cord-005453-4057qib7 15729 30 % % NN cord-005453-4057qib7 15729 31 , , , cord-005453-4057qib7 15729 32 p p NN cord-005453-4057qib7 15729 33 < < XX cord-005453-4057qib7 15729 34 0.0001 0.0001 CD cord-005453-4057qib7 15729 35 ) ) -RRB- cord-005453-4057qib7 15729 36 and and CC cord-005453-4057qib7 15729 37 the the DT cord-005453-4057qib7 15729 38 interval interval NN cord-005453-4057qib7 15729 39 from from IN cord-005453-4057qib7 15729 40 diagnosis diagnosis NN cord-005453-4057qib7 15729 41 to to IN cord-005453-4057qib7 15729 42 transplant transplant NN cord-005453-4057qib7 15729 43 was be VBD cord-005453-4057qib7 15729 44 longer long JJR cord-005453-4057qib7 15729 45 ( ( -LRB- cord-005453-4057qib7 15729 46 5.1 5.1 CD cord-005453-4057qib7 15729 47 versus versus IN cord-005453-4057qib7 15729 48 4.3 4.3 CD cord-005453-4057qib7 15729 49 months month NNS cord-005453-4057qib7 15729 50 , , , cord-005453-4057qib7 15729 51 p= p= NNP cord-005453-4057qib7 15729 52 0.003 0.003 CD cord-005453-4057qib7 15729 53 ) ) -RRB- cord-005453-4057qib7 15729 54 . . . cord-005453-4057qib7 15730 1 By by IN cord-005453-4057qib7 15730 2 multivariate multivariate JJ cord-005453-4057qib7 15730 3 analysis analysis NN cord-005453-4057qib7 15730 4 , , , cord-005453-4057qib7 15730 5 haploidentical haploidentical JJ cord-005453-4057qib7 15730 6 transplants transplant NNS cord-005453-4057qib7 15730 7 were be VBD cord-005453-4057qib7 15730 8 associated associate VBN cord-005453-4057qib7 15730 9 with with IN cord-005453-4057qib7 15730 10 a a DT cord-005453-4057qib7 15730 11 lower low JJR cord-005453-4057qib7 15730 12 relapse relapse NN cord-005453-4057qib7 15730 13 incidence incidence NN cord-005453-4057qib7 15730 14 ( ( -LRB- cord-005453-4057qib7 15730 15 HR hr NN cord-005453-4057qib7 15730 16 : : : cord-005453-4057qib7 15730 17 0,40 0,40 CD cord-005453-4057qib7 15730 18 ( ( -LRB- cord-005453-4057qib7 15730 19 0.21 0.21 CD cord-005453-4057qib7 15730 20 - - SYM cord-005453-4057qib7 15730 21 0.75 0.75 CD cord-005453-4057qib7 15730 22 ; ; : cord-005453-4057qib7 15730 23 p p NN cord-005453-4057qib7 15730 24 = = SYM cord-005453-4057qib7 15730 25 0.004),a 0.004),a CD cord-005453-4057qib7 15730 26 better well JJR cord-005453-4057qib7 15730 27 LFS LFS NNP cord-005453-4057qib7 15730 28 ( ( -LRB- cord-005453-4057qib7 15730 29 HR hr NN cord-005453-4057qib7 15730 30 : : : cord-005453-4057qib7 15730 31 0,46 0,46 CD cord-005453-4057qib7 15730 32 ( ( -LRB- cord-005453-4057qib7 15730 33 0.28 0.28 CD cord-005453-4057qib7 15730 34 - - HYPH cord-005453-4057qib7 15730 35 0.77 0.77 CD cord-005453-4057qib7 15730 36 ; ; . cord-005453-4057qib7 15731 1 p p NN cord-005453-4057qib7 15731 2 = = SYM cord-005453-4057qib7 15731 3 0.003),OS 0.003),os CD cord-005453-4057qib7 15732 1 ( ( -LRB- cord-005453-4057qib7 15732 2 HR HR NNP cord-005453-4057qib7 15732 3 : : : cord-005453-4057qib7 15732 4 0,43 0,43 CD cord-005453-4057qib7 15732 5 ( ( -LRB- cord-005453-4057qib7 15732 6 0.25 0.25 CD cord-005453-4057qib7 15732 7 - - SYM cord-005453-4057qib7 15732 8 0.75 0.75 CD cord-005453-4057qib7 15732 9 ; ; : cord-005453-4057qib7 15732 10 p p NN cord-005453-4057qib7 15732 11 = = SYM cord-005453-4057qib7 15732 12 0.003 0.003 CD cord-005453-4057qib7 15732 13 ) ) -RRB- cord-005453-4057qib7 15732 14 , , , cord-005453-4057qib7 15732 15 and and CC cord-005453-4057qib7 15732 16 GRFS GRFS NNP cord-005453-4057qib7 15732 17 ( ( -LRB- cord-005453-4057qib7 15732 18 HR hr NN cord-005453-4057qib7 15732 19 : : : cord-005453-4057qib7 15732 20 0,53 0,53 CD cord-005453-4057qib7 15732 21 ( ( -LRB- cord-005453-4057qib7 15732 22 0.34 0.34 CD cord-005453-4057qib7 15732 23 - - SYM cord-005453-4057qib7 15732 24 0.84 0.84 CD cord-005453-4057qib7 15732 25 ; ; : cord-005453-4057qib7 15732 26 p p NN cord-005453-4057qib7 15732 27 = = SYM cord-005453-4057qib7 15732 28 0.006)(see 0.006)(see CD cord-005453-4057qib7 15732 29 figure figure NN cord-005453-4057qib7 15732 30 ) ) -RRB- cord-005453-4057qib7 15732 31 . . . cord-005453-4057qib7 15733 1 The the DT cord-005453-4057qib7 15733 2 only only JJ cord-005453-4057qib7 15733 3 other other JJ cord-005453-4057qib7 15733 4 significant significant JJ cord-005453-4057qib7 15733 5 prognostic prognostic JJ cord-005453-4057qib7 15733 6 factor factor NN cord-005453-4057qib7 15733 7 was be VBD cord-005453-4057qib7 15733 8 patient patient JJ cord-005453-4057qib7 15733 9 age age NN cord-005453-4057qib7 15733 10 . . . cord-005453-4057qib7 15734 1 Conclusions conclusion NNS cord-005453-4057qib7 15734 2 : : : cord-005453-4057qib7 15735 1 This this DT cord-005453-4057qib7 15735 2 study study NN cord-005453-4057qib7 15735 3 shows show VBZ cord-005453-4057qib7 15735 4 that that IN cord-005453-4057qib7 15735 5 in in IN cord-005453-4057qib7 15735 6 a a DT cord-005453-4057qib7 15735 7 male male JJ cord-005453-4057qib7 15735 8 patient patient NN cord-005453-4057qib7 15735 9 with with IN cord-005453-4057qib7 15735 10 intermediate intermediate JJ cord-005453-4057qib7 15735 11 risk risk NN cord-005453-4057qib7 15735 12 AML AML NNP cord-005453-4057qib7 15735 13 , , , cord-005453-4057qib7 15735 14 a a DT cord-005453-4057qib7 15735 15 genoidentical genoidentical JJ cord-005453-4057qib7 15735 16 sister sister NN cord-005453-4057qib7 15735 17 donor donor NN cord-005453-4057qib7 15735 18 remains remain VBZ cord-005453-4057qib7 15735 19 associated associate VBN cord-005453-4057qib7 15735 20 with with IN cord-005453-4057qib7 15735 21 a a DT cord-005453-4057qib7 15735 22 better well JJR cord-005453-4057qib7 15735 23 LFS lfs NN cord-005453-4057qib7 15735 24 . . . cord-005453-4057qib7 15736 1 In in IN cord-005453-4057qib7 15736 2 contrast contrast NN cord-005453-4057qib7 15736 3 , , , cord-005453-4057qib7 15736 4 in in IN cord-005453-4057qib7 15736 5 a a DT cord-005453-4057qib7 15736 6 male male JJ cord-005453-4057qib7 15736 7 patient patient NN cord-005453-4057qib7 15736 8 with with IN cord-005453-4057qib7 15736 9 high high JJ cord-005453-4057qib7 15736 10 risk risk NN cord-005453-4057qib7 15736 11 AML AML NNP cord-005453-4057qib7 15736 12 in in IN cord-005453-4057qib7 15736 13 CR1 CR1 NNP cord-005453-4057qib7 15736 14 , , , cord-005453-4057qib7 15736 15 a a DT cord-005453-4057qib7 15736 16 haploidentical haploidentical JJ cord-005453-4057qib7 15736 17 donor donor NN cord-005453-4057qib7 15736 18 may may MD cord-005453-4057qib7 15736 19 be be VB cord-005453-4057qib7 15736 20 a a DT cord-005453-4057qib7 15736 21 better well JJR cord-005453-4057qib7 15736 22 choice choice NN cord-005453-4057qib7 15736 23 than than IN cord-005453-4057qib7 15736 24 an an DT cord-005453-4057qib7 15736 25 HLA HLA NNP cord-005453-4057qib7 15736 26 genoidentical genoidentical JJ cord-005453-4057qib7 15736 27 sister sister NN cord-005453-4057qib7 15736 28 . . . cord-005453-4057qib7 15737 1 Disclosure disclosure NN cord-005453-4057qib7 15737 2 : : : cord-005453-4057qib7 15737 3 Nothing nothing NN cord-005453-4057qib7 15737 4 to to TO cord-005453-4057qib7 15737 5 declare declare VB cord-005453-4057qib7 15737 6 P663 P663 NNS cord-005453-4057qib7 15737 7 Abstract Abstract NNP cord-005453-4057qib7 15737 8 already already RB cord-005453-4057qib7 15737 9 published publish VBN cord-005453-4057qib7 15737 10 . . . cord-005453-4057qib7 15738 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 15738 2 transplant transplant NN cord-005453-4057qib7 15738 3 for for IN cord-005453-4057qib7 15738 4 older old JJR cord-005453-4057qib7 15738 5 acute acute JJ cord-005453-4057qib7 15738 6 leukemia leukemia NN cord-005453-4057qib7 15738 7 patients patient NNS cord-005453-4057qib7 15738 8 : : : cord-005453-4057qib7 15738 9 Improved improve VBN cord-005453-4057qib7 15738 10 survival survival NN cord-005453-4057qib7 15738 11 with with IN cord-005453-4057qib7 15738 12 offspring offspre VBG cord-005453-4057qib7 15738 13 donor donor NN cord-005453-4057qib7 15738 14 in in IN cord-005453-4057qib7 15738 15 comparison comparison NN cord-005453-4057qib7 15738 16 with with IN cord-005453-4057qib7 15738 17 older old JJR cord-005453-4057qib7 15738 18 - - HYPH cord-005453-4057qib7 15738 19 aged aged JJ cord-005453-4057qib7 15738 20 matched match VBN cord-005453-4057qib7 15738 21 siblingsYu siblingsyu CD cord-005453-4057qib7 15738 22 Wang Wang NNP cord-005453-4057qib7 15738 23 1 1 CD cord-005453-4057qib7 15739 1 , , , cord-005453-4057qib7 15739 2 Sheng Sheng NNP cord-005453-4057qib7 15739 3 - - HYPH cord-005453-4057qib7 15739 4 Ye Ye NNP cord-005453-4057qib7 15739 5 Lu Lu NNP cord-005453-4057qib7 15739 6 1 1 CD cord-005453-4057qib7 15739 7 , , , cord-005453-4057qib7 15739 8 Qi Qi NNP cord-005453-4057qib7 15739 9 - - HYPH cord-005453-4057qib7 15739 10 Fa Fa NNP cord-005453-4057qib7 15739 11 Liu Liu NNP cord-005453-4057qib7 15739 12 2 2 CD cord-005453-4057qib7 15739 13 , , , cord-005453-4057qib7 15740 1 De De NNP cord-005453-4057qib7 15740 2 - - HYPH cord-005453-4057qib7 15740 3 Pei Pei NNP cord-005453-4057qib7 15740 4 Wu Wu NNP cord-005453-4057qib7 15740 5 3 3 CD cord-005453-4057qib7 15741 1 , , , cord-005453-4057qib7 15741 2 Xiao Xiao NNP cord-005453-4057qib7 15741 3 - - HYPH cord-005453-4057qib7 15741 4 Jun Jun NNP cord-005453-4057qib7 15741 5 Huang Huang NNP cord-005453-4057qib7 15741 6 1Background 1Background NNP cord-005453-4057qib7 15741 7 : : : cord-005453-4057qib7 15742 1 Post post JJ cord-005453-4057qib7 15742 2 - - JJ cord-005453-4057qib7 15742 3 transplant transplant JJ cord-005453-4057qib7 15742 4 relapse relapse NN cord-005453-4057qib7 15742 5 remains remain VBZ cord-005453-4057qib7 15742 6 the the DT cord-005453-4057qib7 15742 7 major major JJ cord-005453-4057qib7 15742 8 cause cause NN cord-005453-4057qib7 15742 9 of of IN cord-005453-4057qib7 15742 10 death death NN cord-005453-4057qib7 15742 11 of of IN cord-005453-4057qib7 15742 12 treatment treatment NN cord-005453-4057qib7 15742 13 failure failure NN cord-005453-4057qib7 15742 14 . . . cord-005453-4057qib7 15743 1 Therapeutic therapeutic JJ cord-005453-4057qib7 15743 2 options option NNS cord-005453-4057qib7 15743 3 for for IN cord-005453-4057qib7 15743 4 relapse relapse NN cord-005453-4057qib7 15743 5 after after IN cord-005453-4057qib7 15743 6 first first JJ cord-005453-4057qib7 15743 7 allogeneic allogeneic NN cord-005453-4057qib7 15743 8 stem stem NN cord-005453-4057qib7 15743 9 cell cell NN cord-005453-4057qib7 15743 10 transplant transplant NN cord-005453-4057qib7 15743 11 ( ( -LRB- cord-005453-4057qib7 15743 12 1st 1st JJ cord-005453-4057qib7 15743 13 HSCT HSCT NNP cord-005453-4057qib7 15743 14 ) ) -RRB- cord-005453-4057qib7 15743 15 include include VBP cord-005453-4057qib7 15743 16 chemotherapy chemotherapy NN cord-005453-4057qib7 15743 17 followed follow VBN cord-005453-4057qib7 15743 18 by by IN cord-005453-4057qib7 15743 19 donor donor NN cord-005453-4057qib7 15743 20 lymphocyte lymphocyte NN cord-005453-4057qib7 15743 21 infusion infusion NN cord-005453-4057qib7 15743 22 or or CC cord-005453-4057qib7 15743 23 second second JJ cord-005453-4057qib7 15743 24 allo allo NN cord-005453-4057qib7 15743 25 - - HYPH cord-005453-4057qib7 15743 26 HSCT HSCT NNP cord-005453-4057qib7 15743 27 ( ( -LRB- cord-005453-4057qib7 15743 28 2nd 2nd JJ cord-005453-4057qib7 15743 29 HSCT HSCT NNP cord-005453-4057qib7 15743 30 ) ) -RRB- cord-005453-4057qib7 15743 31 from from IN cord-005453-4057qib7 15743 32 the the DT cord-005453-4057qib7 15743 33 original original JJ cord-005453-4057qib7 15743 34 donor donor NN cord-005453-4057qib7 15743 35 or or CC cord-005453-4057qib7 15743 36 change change NN cord-005453-4057qib7 15743 37 to to IN cord-005453-4057qib7 15743 38 another another DT cord-005453-4057qib7 15743 39 donor donor NN cord-005453-4057qib7 15743 40 . . . cord-005453-4057qib7 15744 1 However however RB cord-005453-4057qib7 15744 2 , , , cord-005453-4057qib7 15744 3 there there EX cord-005453-4057qib7 15744 4 is be VBZ cord-005453-4057qib7 15744 5 unclear unclear JJ cord-005453-4057qib7 15744 6 outcome outcome NN cord-005453-4057qib7 15744 7 for for IN cord-005453-4057qib7 15744 8 different different JJ cord-005453-4057qib7 15744 9 treatment treatment NN cord-005453-4057qib7 15744 10 approach approach NN cord-005453-4057qib7 15744 11 . . . cord-005453-4057qib7 15745 1 In in IN cord-005453-4057qib7 15745 2 this this DT cord-005453-4057qib7 15745 3 retrospective retrospective JJ cord-005453-4057qib7 15745 4 cohort cohort NN cord-005453-4057qib7 15745 5 study study NN cord-005453-4057qib7 15745 6 , , , cord-005453-4057qib7 15745 7 we -PRON- PRP cord-005453-4057qib7 15745 8 aim aim VBP cord-005453-4057qib7 15745 9 to to TO cord-005453-4057qib7 15745 10 compare compare VB cord-005453-4057qib7 15745 11 the the DT cord-005453-4057qib7 15745 12 clinical clinical JJ cord-005453-4057qib7 15745 13 outcome outcome NN cord-005453-4057qib7 15745 14 after after IN cord-005453-4057qib7 15745 15 different different JJ cord-005453-4057qib7 15745 16 treatment treatment NN cord-005453-4057qib7 15745 17 strategy strategy NN cord-005453-4057qib7 15745 18 for for IN cord-005453-4057qib7 15745 19 relapse relapse NN cord-005453-4057qib7 15745 20 after after IN cord-005453-4057qib7 15745 21 first first JJ cord-005453-4057qib7 15745 22 Allo Allo NNP cord-005453-4057qib7 15745 23 - - HYPH cord-005453-4057qib7 15745 24 HSCT.Methods HSCT.Methods NNP cord-005453-4057qib7 15745 25 : : : cord-005453-4057qib7 15746 1 Between between IN cord-005453-4057qib7 15746 2 1992 1992 CD cord-005453-4057qib7 15746 3 Jan Jan NNP cord-005453-4057qib7 15746 4 and and CC cord-005453-4057qib7 15746 5 2018 2018 CD cord-005453-4057qib7 15747 1 Oct Oct NNP cord-005453-4057qib7 15747 2 , , , cord-005453-4057qib7 15747 3 1493 1493 CD cord-005453-4057qib7 15747 4 consecutive consecutive JJ cord-005453-4057qib7 15747 5 patients patient NNS cord-005453-4057qib7 15747 6 receiving receive VBG cord-005453-4057qib7 15747 7 1 1 CD cord-005453-4057qib7 15747 8 st st NNP cord-005453-4057qib7 15747 9 HSCT HSCT NNP cord-005453-4057qib7 15747 10 registered register VBD cord-005453-4057qib7 15747 11 to to IN cord-005453-4057qib7 15747 12 the the DT cord-005453-4057qib7 15747 13 BMT BMT NNP cord-005453-4057qib7 15747 14 database database NN cord-005453-4057qib7 15747 15 in in IN cord-005453-4057qib7 15747 16 National National NNP cord-005453-4057qib7 15747 17 Taiwan Taiwan NNP cord-005453-4057qib7 15747 18 University University NNP cord-005453-4057qib7 15747 19 Hospital Hospital NNP cord-005453-4057qib7 15747 20 were be VBD cord-005453-4057qib7 15747 21 analyzed analyze VBN cord-005453-4057qib7 15747 22 . . . cord-005453-4057qib7 15748 1 Among among IN cord-005453-4057qib7 15748 2 them -PRON- PRP cord-005453-4057qib7 15748 3 , , , cord-005453-4057qib7 15748 4 580 580 CD cord-005453-4057qib7 15748 5 cases case NNS cord-005453-4057qib7 15748 6 had have VBD cord-005453-4057qib7 15748 7 relapsed relapse VBN cord-005453-4057qib7 15748 8 after after IN cord-005453-4057qib7 15748 9 first first JJ cord-005453-4057qib7 15748 10 Allo Allo NNP cord-005453-4057qib7 15748 11 - - HYPH cord-005453-4057qib7 15748 12 HSCT HSCT NNP cord-005453-4057qib7 15748 13 . . . cord-005453-4057qib7 15749 1 One one CD cord-005453-4057qib7 15749 2 hundred hundred CD cord-005453-4057qib7 15749 3 and and CC cord-005453-4057qib7 15749 4 three three CD cord-005453-4057qib7 15749 5 patients patient NNS cord-005453-4057qib7 15749 6 who who WP cord-005453-4057qib7 15749 7 received receive VBD cord-005453-4057qib7 15749 8 no no DT cord-005453-4057qib7 15749 9 treatment treatment NN cord-005453-4057qib7 15749 10 after after IN cord-005453-4057qib7 15749 11 relapse relapse NN cord-005453-4057qib7 15749 12 or or CC cord-005453-4057qib7 15749 13 with with IN cord-005453-4057qib7 15749 14 incomplete incomplete JJ cord-005453-4057qib7 15749 15 data datum NNS cord-005453-4057qib7 15749 16 were be VBD cord-005453-4057qib7 15749 17 excluded exclude VBN cord-005453-4057qib7 15749 18 . . . cord-005453-4057qib7 15750 1 Their -PRON- PRP$ cord-005453-4057qib7 15750 2 transplant transplant NN cord-005453-4057qib7 15750 3 data datum NNS cord-005453-4057qib7 15750 4 was be VBD cord-005453-4057qib7 15750 5 collected collect VBN cord-005453-4057qib7 15750 6 following follow VBG cord-005453-4057qib7 15750 7 the the DT cord-005453-4057qib7 15750 8 EBMT EBMT NNP cord-005453-4057qib7 15750 9 Registry Registry NNP cord-005453-4057qib7 15750 10 data data NN cord-005453-4057qib7 15750 11 collection collection NN cord-005453-4057qib7 15750 12 forms form NNS cord-005453-4057qib7 15750 13 and and CC cord-005453-4057qib7 15750 14 manuals manual NNS cord-005453-4057qib7 15750 15 . . . cord-005453-4057qib7 15751 1 Overall overall JJ cord-005453-4057qib7 15751 2 survival survival NN cord-005453-4057qib7 15751 3 rate rate NN cord-005453-4057qib7 15751 4 and and CC cord-005453-4057qib7 15751 5 progression progression NN cord-005453-4057qib7 15751 6 free free JJ cord-005453-4057qib7 15751 7 survival survival NN cord-005453-4057qib7 15751 8 rate rate NN cord-005453-4057qib7 15751 9 were be VBD cord-005453-4057qib7 15751 10 performed perform VBN cord-005453-4057qib7 15751 11 by by IN cord-005453-4057qib7 15751 12 the the DT cord-005453-4057qib7 15751 13 Kaplan Kaplan NNP cord-005453-4057qib7 15751 14 - - HYPH cord-005453-4057qib7 15751 15 Meier Meier NNP cord-005453-4057qib7 15751 16 method method NN cord-005453-4057qib7 15751 17 . . . cord-005453-4057qib7 15752 1 Univariate univariate JJ cord-005453-4057qib7 15752 2 and and CC cord-005453-4057qib7 15752 3 multivariate multivariate JJ cord-005453-4057qib7 15752 4 analysis analysis NN cord-005453-4057qib7 15752 5 were be VBD cord-005453-4057qib7 15752 6 performed perform VBN cord-005453-4057qib7 15752 7 using use VBG cord-005453-4057qib7 15752 8 Cox Cox NNP cord-005453-4057qib7 15752 9 proportional proportional JJ cord-005453-4057qib7 15752 10 hazard hazard NN cord-005453-4057qib7 15752 11 regression regression NN cord-005453-4057qib7 15752 12 model model NN cord-005453-4057qib7 15752 13 . . . cord-005453-4057qib7 15753 1 Results result NNS cord-005453-4057qib7 15753 2 : : : cord-005453-4057qib7 15754 1 Of of IN cord-005453-4057qib7 15754 2 the the DT cord-005453-4057qib7 15754 3 477 477 CD cord-005453-4057qib7 15754 4 patients patient NNS cord-005453-4057qib7 15754 5 who who WP cord-005453-4057qib7 15754 6 experienced experience VBD cord-005453-4057qib7 15754 7 relapse relapse NN cord-005453-4057qib7 15754 8 after after IN cord-005453-4057qib7 15754 9 1 1 CD cord-005453-4057qib7 15754 10 st st NNP cord-005453-4057qib7 15754 11 HSCT HSCT NNP cord-005453-4057qib7 15754 12 , , , cord-005453-4057qib7 15754 13 total total JJ cord-005453-4057qib7 15754 14 244 244 CD cord-005453-4057qib7 15754 15 patients patient NNS cord-005453-4057qib7 15754 16 ( ( -LRB- cord-005453-4057qib7 15754 17 51 51 CD cord-005453-4057qib7 15754 18 % % NN cord-005453-4057qib7 15754 19 ) ) -RRB- cord-005453-4057qib7 15754 20 received receive VBD cord-005453-4057qib7 15754 21 chemotherapy chemotherapy NN cord-005453-4057qib7 15754 22 followed follow VBN cord-005453-4057qib7 15754 23 by by IN cord-005453-4057qib7 15754 24 DLI DLI NNP cord-005453-4057qib7 15754 25 or or CC cord-005453-4057qib7 15754 26 2 2 CD cord-005453-4057qib7 15754 27 nd nd NNP cord-005453-4057qib7 15754 28 HSCT HSCT NNP cord-005453-4057qib7 15754 29 from from IN cord-005453-4057qib7 15754 30 the the DT cord-005453-4057qib7 15754 31 same same JJ cord-005453-4057qib7 15754 32 donor donor NN cord-005453-4057qib7 15754 33 ( ( -LRB- cord-005453-4057qib7 15754 34 no no DT cord-005453-4057qib7 15754 35 change change NN cord-005453-4057qib7 15754 36 group group NN cord-005453-4057qib7 15754 37 ) ) -RRB- cord-005453-4057qib7 15754 38 , , , cord-005453-4057qib7 15754 39 36 36 CD cord-005453-4057qib7 15754 40 patient patient NN cord-005453-4057qib7 15754 41 ( ( -LRB- cord-005453-4057qib7 15754 42 8 8 CD cord-005453-4057qib7 15754 43 % % NN cord-005453-4057qib7 15754 44 ) ) -RRB- cord-005453-4057qib7 15754 45 received receive VBD cord-005453-4057qib7 15754 46 chemotherapy chemotherapy NN cord-005453-4057qib7 15754 47 followed follow VBN cord-005453-4057qib7 15754 48 by by IN cord-005453-4057qib7 15754 49 2 2 CD cord-005453-4057qib7 15754 50 nd nd NNP cord-005453-4057qib7 15754 51 HSCT HSCT NNP cord-005453-4057qib7 15754 52 from from IN cord-005453-4057qib7 15754 53 different different JJ cord-005453-4057qib7 15754 54 donors donor NNS cord-005453-4057qib7 15754 55 ( ( -LRB- cord-005453-4057qib7 15754 56 change change NN cord-005453-4057qib7 15754 57 group group NN cord-005453-4057qib7 15754 58 ) ) -RRB- cord-005453-4057qib7 15754 59 , , , cord-005453-4057qib7 15754 60 and and CC cord-005453-4057qib7 15754 61 197 197 CD cord-005453-4057qib7 15754 62 ( ( -LRB- cord-005453-4057qib7 15754 63 41 41 CD cord-005453-4057qib7 15754 64 % % NN cord-005453-4057qib7 15754 65 ) ) -RRB- cord-005453-4057qib7 15754 66 had have VBD cord-005453-4057qib7 15754 67 conventional conventional JJ cord-005453-4057qib7 15754 68 chemotherapy chemotherapy NN cord-005453-4057qib7 15754 69 alone alone RB cord-005453-4057qib7 15754 70 . . . cord-005453-4057qib7 15755 1 The the DT cord-005453-4057qib7 15755 2 patients patient NNS cord-005453-4057qib7 15755 3 in in IN cord-005453-4057qib7 15755 4 " " `` cord-005453-4057qib7 15755 5 change change NN cord-005453-4057qib7 15755 6 group group NN cord-005453-4057qib7 15755 7 " " '' cord-005453-4057qib7 15755 8 were be VBD cord-005453-4057qib7 15755 9 younger young JJR cord-005453-4057qib7 15755 10 ( ( -LRB- cord-005453-4057qib7 15755 11 median median NN cord-005453-4057qib7 15755 12 age age NN cord-005453-4057qib7 15755 13 29 29 CD cord-005453-4057qib7 15755 14 vs vs IN cord-005453-4057qib7 15755 15 37 37 CD cord-005453-4057qib7 15755 16 , , , cord-005453-4057qib7 15755 17 p p NN cord-005453-4057qib7 15755 18 = = SYM cord-005453-4057qib7 15755 19 .02 .02 NFP cord-005453-4057qib7 15755 20 ) ) -RRB- cord-005453-4057qib7 15755 21 , , , cord-005453-4057qib7 15755 22 and and CC cord-005453-4057qib7 15755 23 had have VBD cord-005453-4057qib7 15755 24 more more JJR cord-005453-4057qib7 15755 25 patients patient NNS cord-005453-4057qib7 15755 26 achieving achieve VBG cord-005453-4057qib7 15755 27 complete complete JJ cord-005453-4057qib7 15755 28 remission remission NN cord-005453-4057qib7 15755 29 ( ( -LRB- cord-005453-4057qib7 15755 30 CR CR NNP cord-005453-4057qib7 15755 31 ) ) -RRB- cord-005453-4057qib7 15755 32 prior prior RB cord-005453-4057qib7 15755 33 to to IN cord-005453-4057qib7 15755 34 2 2 CD cord-005453-4057qib7 15755 35 nd nd NNP cord-005453-4057qib7 15755 36 HSCT HSCT NNP cord-005453-4057qib7 15755 37 ( ( -LRB- cord-005453-4057qib7 15755 38 44 44 CD cord-005453-4057qib7 15755 39 % % NN cord-005453-4057qib7 15755 40 vs vs IN cord-005453-4057qib7 15755 41 10 10 CD cord-005453-4057qib7 15755 42 % % NN cord-005453-4057qib7 15755 43 , , , cord-005453-4057qib7 15755 44 p p NN cord-005453-4057qib7 15755 45 = = SYM cord-005453-4057qib7 15755 46 < < XX cord-005453-4057qib7 15755 47 .01 .01 NFP cord-005453-4057qib7 15755 48 ) ) -RRB- cord-005453-4057qib7 15755 49 than than IN cord-005453-4057qib7 15755 50 patients patient NNS cord-005453-4057qib7 15755 51 in in IN cord-005453-4057qib7 15755 52 " " `` cord-005453-4057qib7 15755 53 no no DT cord-005453-4057qib7 15755 54 change change NN cord-005453-4057qib7 15755 55 group group NN cord-005453-4057qib7 15755 56 " " '' cord-005453-4057qib7 15755 57 . . . cord-005453-4057qib7 15756 1 After after IN cord-005453-4057qib7 15756 2 the the DT cord-005453-4057qib7 15756 3 2 2 CD cord-005453-4057qib7 15756 4 nd nd NNP cord-005453-4057qib7 15756 5 HSCT HSCT NNP cord-005453-4057qib7 15756 6 , , , cord-005453-4057qib7 15756 7 the the DT cord-005453-4057qib7 15756 8 CR cr NN cord-005453-4057qib7 15756 9 was be VBD cord-005453-4057qib7 15756 10 68 68 CD cord-005453-4057qib7 15756 11 % % NN cord-005453-4057qib7 15756 12 for for IN cord-005453-4057qib7 15756 13 " " `` cord-005453-4057qib7 15756 14 no no DT cord-005453-4057qib7 15756 15 change change NN cord-005453-4057qib7 15756 16 group group NN cord-005453-4057qib7 15756 17 " " '' cord-005453-4057qib7 15756 18 and and CC cord-005453-4057qib7 15756 19 91 91 CD cord-005453-4057qib7 15756 20 % % NN cord-005453-4057qib7 15756 21 for for IN cord-005453-4057qib7 15756 22 " " `` cord-005453-4057qib7 15756 23 change change NN cord-005453-4057qib7 15756 24 group group NN cord-005453-4057qib7 15756 25 " " '' cord-005453-4057qib7 15756 26 . . . cord-005453-4057qib7 15757 1 The the DT cord-005453-4057qib7 15757 2 progression progression NN cord-005453-4057qib7 15757 3 - - HYPH cord-005453-4057qib7 15757 4 free free JJ cord-005453-4057qib7 15757 5 survival survival NN cord-005453-4057qib7 15757 6 at at IN cord-005453-4057qib7 15757 7 3-year 3-year CD cord-005453-4057qib7 15757 8 and and CC cord-005453-4057qib7 15757 9 5-year 5-year CD cord-005453-4057qib7 15757 10 were be VBD cord-005453-4057qib7 15757 11 10.5 10.5 CD cord-005453-4057qib7 15757 12 % % NN cord-005453-4057qib7 15757 13 and and CC cord-005453-4057qib7 15757 14 5.9 5.9 CD cord-005453-4057qib7 15757 15 % % NN cord-005453-4057qib7 15758 1 ( ( -LRB- cord-005453-4057qib7 15758 2 Fig Fig NNP cord-005453-4057qib7 15758 3 1A 1a NN cord-005453-4057qib7 15758 4 , , , cord-005453-4057qib7 15758 5 p p NN cord-005453-4057qib7 15758 6 = = SYM cord-005453-4057qib7 15758 7 .0438 .0438 NFP cord-005453-4057qib7 15758 8 % % NN cord-005453-4057qib7 15758 9 ) ) -RRB- cord-005453-4057qib7 15758 10 , , , cord-005453-4057qib7 15758 11 respectively respectively RB cord-005453-4057qib7 15758 12 , , , cord-005453-4057qib7 15758 13 for for IN cord-005453-4057qib7 15758 14 " " `` cord-005453-4057qib7 15758 15 no no DT cord-005453-4057qib7 15758 16 change change NN cord-005453-4057qib7 15758 17 group group NN cord-005453-4057qib7 15758 18 " " '' cord-005453-4057qib7 15758 19 and and CC cord-005453-4057qib7 15758 20 9.4 9.4 CD cord-005453-4057qib7 15758 21 % % NN cord-005453-4057qib7 15758 22 and and CC cord-005453-4057qib7 15758 23 9.4 9.4 CD cord-005453-4057qib7 15758 24 % % NN cord-005453-4057qib7 15758 25 , , , cord-005453-4057qib7 15758 26 respectively respectively RB cord-005453-4057qib7 15758 27 , , , cord-005453-4057qib7 15758 28 for for IN cord-005453-4057qib7 15758 29 " " `` cord-005453-4057qib7 15758 30 change change NN cord-005453-4057qib7 15758 31 group group NN cord-005453-4057qib7 15758 32 " " '' cord-005453-4057qib7 15758 33 . . . cord-005453-4057qib7 15759 1 While while IN cord-005453-4057qib7 15759 2 the the DT cord-005453-4057qib7 15759 3 overall overall JJ cord-005453-4057qib7 15759 4 survival survival NN cord-005453-4057qib7 15759 5 ( ( -LRB- cord-005453-4057qib7 15759 6 OS OS NNP cord-005453-4057qib7 15759 7 ) ) -RRB- cord-005453-4057qib7 15759 8 at at IN cord-005453-4057qib7 15759 9 3-year 3-year CD cord-005453-4057qib7 15759 10 and and CC cord-005453-4057qib7 15759 11 5-year 5-year CD cord-005453-4057qib7 15759 12 were be VBD cord-005453-4057qib7 15759 13 15.8 15.8 CD cord-005453-4057qib7 15759 14 % % NN cord-005453-4057qib7 15759 15 and and CC cord-005453-4057qib7 15759 16 9 9 CD cord-005453-4057qib7 15759 17 % % NN cord-005453-4057qib7 15760 1 ( ( -LRB- cord-005453-4057qib7 15760 2 Fig Fig NNP cord-005453-4057qib7 15760 3 1B 1b NN cord-005453-4057qib7 15760 4 , , , cord-005453-4057qib7 15760 5 p p NN cord-005453-4057qib7 15760 6 = = SYM cord-005453-4057qib7 15760 7 .3459 .3459 : cord-005453-4057qib7 15760 8 % % NN cord-005453-4057qib7 15760 9 ) ) -RRB- cord-005453-4057qib7 15760 10 , , , cord-005453-4057qib7 15760 11 respectively respectively RB cord-005453-4057qib7 15760 12 , , , cord-005453-4057qib7 15760 13 for for IN cord-005453-4057qib7 15760 14 " " `` cord-005453-4057qib7 15760 15 no no DT cord-005453-4057qib7 15760 16 change change NN cord-005453-4057qib7 15760 17 group group NN cord-005453-4057qib7 15760 18 " " '' cord-005453-4057qib7 15760 19 and and CC cord-005453-4057qib7 15760 20 13.5 13.5 CD cord-005453-4057qib7 15760 21 % % NN cord-005453-4057qib7 15760 22 and and CC cord-005453-4057qib7 15760 23 9 9 CD cord-005453-4057qib7 15760 24 % % NN cord-005453-4057qib7 15760 25 , , , cord-005453-4057qib7 15760 26 respectively respectively RB cord-005453-4057qib7 15760 27 , , , cord-005453-4057qib7 15760 28 for for IN cord-005453-4057qib7 15760 29 " " `` cord-005453-4057qib7 15760 30 change change NN cord-005453-4057qib7 15760 31 group group NN cord-005453-4057qib7 15760 32 " " '' cord-005453-4057qib7 15760 33 . . . cord-005453-4057qib7 15761 1 Those those DT cord-005453-4057qib7 15761 2 who who WP cord-005453-4057qib7 15761 3 achieved achieve VBD cord-005453-4057qib7 15761 4 CR CR NNP cord-005453-4057qib7 15761 5 prior prior RB cord-005453-4057qib7 15761 6 to to IN cord-005453-4057qib7 15761 7 2 2 CD cord-005453-4057qib7 15761 8 nd nd NNP cord-005453-4057qib7 15761 9 HSCT HSCT NNP cord-005453-4057qib7 15761 10 had have VBD cord-005453-4057qib7 15761 11 a a DT cord-005453-4057qib7 15761 12 trend trend NN cord-005453-4057qib7 15761 13 of of IN cord-005453-4057qib7 15761 14 better well JJR cord-005453-4057qib7 15761 15 OS os NN cord-005453-4057qib7 15761 16 than than IN cord-005453-4057qib7 15761 17 those those DT cord-005453-4057qib7 15761 18 without without IN cord-005453-4057qib7 15761 19 CR CR NNP cord-005453-4057qib7 15761 20 ( ( -LRB- cord-005453-4057qib7 15761 21 17.5 17.5 CD cord-005453-4057qib7 15761 22 % % NN cord-005453-4057qib7 15761 23 vs vs IN cord-005453-4057qib7 15761 24 8.7 8.7 CD cord-005453-4057qib7 15761 25 % % NN cord-005453-4057qib7 15761 26 at at IN cord-005453-4057qib7 15761 27 3-year 3-year CD cord-005453-4057qib7 15761 28 ; ; : cord-005453-4057qib7 15761 29 8.7 8.7 CD cord-005453-4057qib7 15761 30 % % NN cord-005453-4057qib7 15761 31 vs vs IN cord-005453-4057qib7 15761 32 9.1 9.1 CD cord-005453-4057qib7 15761 33 % % NN cord-005453-4057qib7 15761 34 at at IN cord-005453-4057qib7 15761 35 5year 5year CD cord-005453-4057qib7 15761 36 , , , cord-005453-4057qib7 15761 37 p p NN cord-005453-4057qib7 15761 38 = = SYM cord-005453-4057qib7 15761 39 .0365 .0365 . cord-005453-4057qib7 15761 40 ) ) -RRB- cord-005453-4057qib7 15762 1 ( ( -LRB- cord-005453-4057qib7 15762 2 Fig Fig NNP cord-005453-4057qib7 15762 3 1C 1c NN cord-005453-4057qib7 15762 4 ) ) -RRB- cord-005453-4057qib7 15762 5 . . . cord-005453-4057qib7 15763 1 There there EX cord-005453-4057qib7 15763 2 were be VBD cord-005453-4057qib7 15763 3 1 1 CD cord-005453-4057qib7 15763 4 cases case NNS cord-005453-4057qib7 15763 5 survived survive VBN cord-005453-4057qib7 15763 6 for for IN cord-005453-4057qib7 15763 7 more more JJR cord-005453-4057qib7 15763 8 than than IN cord-005453-4057qib7 15763 9 10 10 CD cord-005453-4057qib7 15763 10 years year NNS cord-005453-4057qib7 15763 11 in in IN cord-005453-4057qib7 15763 12 " " `` cord-005453-4057qib7 15763 13 change change NN cord-005453-4057qib7 15763 14 donor donor NN cord-005453-4057qib7 15763 15 group group NN cord-005453-4057qib7 15763 16 " " '' cord-005453-4057qib7 15763 17 and and CC cord-005453-4057qib7 15764 1 6 6 CD cord-005453-4057qib7 15764 2 cases case NNS cord-005453-4057qib7 15764 3 survived survive VBD cord-005453-4057qib7 15764 4 more more JJR cord-005453-4057qib7 15764 5 than than IN cord-005453-4057qib7 15764 6 10 10 CD cord-005453-4057qib7 15764 7 years year NNS cord-005453-4057qib7 15764 8 in in IN cord-005453-4057qib7 15764 9 " " `` cord-005453-4057qib7 15764 10 no no DT cord-005453-4057qib7 15764 11 change change NN cord-005453-4057qib7 15764 12 group group NN cord-005453-4057qib7 15764 13 " " '' cord-005453-4057qib7 15764 14 . . . cord-005453-4057qib7 15765 1 Only only RB cord-005453-4057qib7 15765 2 one one CD cord-005453-4057qib7 15765 3 had have VBD cord-005453-4057qib7 15765 4 developed develop VBN cord-005453-4057qib7 15765 5 relapse relapse NN cord-005453-4057qib7 15765 6 after after IN cord-005453-4057qib7 15765 7 2 2 CD cord-005453-4057qib7 15765 8 nd nd NNP cord-005453-4057qib7 15765 9 HSCT HSCT NNP cord-005453-4057qib7 15765 10 but but CC cord-005453-4057qib7 15765 11 achieved achieve VBD cord-005453-4057qib7 15765 12 subsequent subsequent JJ cord-005453-4057qib7 15765 13 remission remission NN cord-005453-4057qib7 15765 14 again again RB cord-005453-4057qib7 15765 15 . . . cord-005453-4057qib7 15766 1 Conclusions conclusion NNS cord-005453-4057qib7 15766 2 : : : cord-005453-4057qib7 15767 1 Our -PRON- PRP$ cord-005453-4057qib7 15767 2 study study NN cord-005453-4057qib7 15767 3 shows show VBZ cord-005453-4057qib7 15767 4 that that IN cord-005453-4057qib7 15767 5 change change VBP cord-005453-4057qib7 15767 6 donor donor NN cord-005453-4057qib7 15767 7 had have VBD cord-005453-4057qib7 15767 8 similar similar JJ cord-005453-4057qib7 15767 9 poor poor JJ cord-005453-4057qib7 15767 10 outcome outcome NN cord-005453-4057qib7 15767 11 comparing compare VBG cord-005453-4057qib7 15767 12 to to IN cord-005453-4057qib7 15767 13 those those DT cord-005453-4057qib7 15767 14 using use VBG cord-005453-4057qib7 15767 15 the the DT cord-005453-4057qib7 15767 16 same same JJ cord-005453-4057qib7 15767 17 donor donor NN cord-005453-4057qib7 15767 18 after after IN cord-005453-4057qib7 15767 19 the the DT cord-005453-4057qib7 15767 20 1 1 CD cord-005453-4057qib7 15767 21 st st NNP cord-005453-4057qib7 15767 22 HSCT HSCT NNP cord-005453-4057qib7 15767 23 . . . cord-005453-4057qib7 15768 1 Patients patient NNS cord-005453-4057qib7 15768 2 who who WP cord-005453-4057qib7 15768 3 achieved achieve VBD cord-005453-4057qib7 15768 4 CR CR NNP cord-005453-4057qib7 15768 5 before before IN cord-005453-4057qib7 15768 6 2nd 2nd JJ cord-005453-4057qib7 15768 7 HSCT HSCT NNP cord-005453-4057qib7 15768 8 had have VBD cord-005453-4057qib7 15768 9 a a DT cord-005453-4057qib7 15768 10 trend trend NN cord-005453-4057qib7 15768 11 of of IN cord-005453-4057qib7 15768 12 better well JJR cord-005453-4057qib7 15768 13 OS os NN cord-005453-4057qib7 15768 14 than than IN cord-005453-4057qib7 15768 15 those those DT cord-005453-4057qib7 15768 16 without without IN cord-005453-4057qib7 15768 17 remission remission NN cord-005453-4057qib7 15768 18 and and CC cord-005453-4057qib7 15769 1 the the DT cord-005453-4057qib7 15769 2 long long JJ cord-005453-4057qib7 15769 3 - - HYPH cord-005453-4057qib7 15769 4 term term NN cord-005453-4057qib7 15769 5 survivors survivor NNS cord-005453-4057qib7 15769 6 were be VBD cord-005453-4057qib7 15769 7 only only RB cord-005453-4057qib7 15769 8 those those DT cord-005453-4057qib7 15769 9 who who WP cord-005453-4057qib7 15769 10 achieved achieve VBD cord-005453-4057qib7 15769 11 CR CR NNP cord-005453-4057qib7 15769 12 prior prior RB cord-005453-4057qib7 15769 13 to to IN cord-005453-4057qib7 15769 14 2 2 CD cord-005453-4057qib7 15769 15 nd nd NNP cord-005453-4057qib7 15769 16 HSCT HSCT NNP cord-005453-4057qib7 15769 17 . . . cord-005453-4057qib7 15770 1 Novel novel JJ cord-005453-4057qib7 15770 2 therapy therapy NN cord-005453-4057qib7 15770 3 for for IN cord-005453-4057qib7 15770 4 CR cr NN cord-005453-4057qib7 15770 5 induction induction NN cord-005453-4057qib7 15770 6 would would MD cord-005453-4057qib7 15770 7 be be VB cord-005453-4057qib7 15770 8 warrant warrant NN cord-005453-4057qib7 15770 9 for for IN cord-005453-4057qib7 15770 10 this this DT cord-005453-4057qib7 15770 11 poor poor JJ cord-005453-4057qib7 15770 12 prognostic prognostic JJ cord-005453-4057qib7 15770 13 population population NN cord-005453-4057qib7 15770 14 . . . cord-005453-4057qib7 15771 1 Disclosure disclosure NN cord-005453-4057qib7 15771 2 : : : cord-005453-4057qib7 15771 3 Nothing nothing NN cord-005453-4057qib7 15771 4 to to TO cord-005453-4057qib7 15771 5 declare declare VB cord-005453-4057qib7 15771 6 Functional functional JJ cord-005453-4057qib7 15771 7 relevance relevance NN cord-005453-4057qib7 15771 8 of of IN cord-005453-4057qib7 15771 9 fetal fetal JJ cord-005453-4057qib7 15771 10 microchimerism microchimerism NN cord-005453-4057qib7 15771 11 in in IN cord-005453-4057qib7 15771 12 NK NK NNP cord-005453-4057qib7 15771 13 cell cell NN cord-005453-4057qib7 15771 14 cytotoxicity cytotoxicity NN cord-005453-4057qib7 15771 15 against against IN cord-005453-4057qib7 15771 16 leukemic leukemic JJ cord-005453-4057qib7 15771 17 blasts blast NNS cord-005453-4057qib7 15771 18 in in IN cord-005453-4057qib7 15771 19 children child NNS cord-005453-4057qib7 15771 20 : : : cord-005453-4057qib7 15772 1 A a DT cord-005453-4057qib7 15772 2 role role NN cord-005453-4057qib7 15772 3 for for IN cord-005453-4057qib7 15772 4 HLA HLA NNP cord-005453-4057qib7 15772 5 - - HYPH cord-005453-4057qib7 15772 6 C1 C1 NNP cord-005453-4057qib7 15772 7 and and CC cord-005453-4057qib7 15772 8 KIR2DL2 KIR2DL2 NNS cord-005453-4057qib7 15772 9 / / SYM cord-005453-4057qib7 15772 10 S2?Background s2?background NN cord-005453-4057qib7 15772 11 : : : cord-005453-4057qib7 15773 1 Allogeneic allogeneic IN cord-005453-4057qib7 15773 2 stem stem VBP cord-005453-4057qib7 15773 3 cell cell NN cord-005453-4057qib7 15773 4 transplantation transplantation NN cord-005453-4057qib7 15773 5 ( ( -LRB- cord-005453-4057qib7 15773 6 allo allo FW cord-005453-4057qib7 15773 7 - - HYPH cord-005453-4057qib7 15773 8 SCT SCT NNP cord-005453-4057qib7 15773 9 ) ) -RRB- cord-005453-4057qib7 15773 10 remains remain VBZ cord-005453-4057qib7 15773 11 the the DT cord-005453-4057qib7 15773 12 most most RBS cord-005453-4057qib7 15773 13 effective effective JJ cord-005453-4057qib7 15773 14 curative curative JJ cord-005453-4057qib7 15773 15 intent intent NN cord-005453-4057qib7 15773 16 therapy therapy NN cord-005453-4057qib7 15773 17 for for IN cord-005453-4057qib7 15773 18 patients patient NNS cord-005453-4057qib7 15773 19 with with IN cord-005453-4057qib7 15773 20 unfavorable unfavorable JJ cord-005453-4057qib7 15773 21 risk risk NN cord-005453-4057qib7 15773 22 acute acute JJ cord-005453-4057qib7 15773 23 leukemia leukemia NN cord-005453-4057qib7 15773 24 . . . cord-005453-4057qib7 15774 1 Various various JJ cord-005453-4057qib7 15774 2 donor donor NN cord-005453-4057qib7 15774 3 options option NNS cord-005453-4057qib7 15774 4 are be VBP cord-005453-4057qib7 15774 5 available available JJ cord-005453-4057qib7 15774 6 for for IN cord-005453-4057qib7 15774 7 the the DT cord-005453-4057qib7 15774 8 patient patient NN cord-005453-4057qib7 15774 9 who who WP cord-005453-4057qib7 15774 10 lacks lack VBZ cord-005453-4057qib7 15774 11 an an DT cord-005453-4057qib7 15774 12 HLA HLA NNP cord-005453-4057qib7 15774 13 - - HYPH cord-005453-4057qib7 15774 14 matched match VBN cord-005453-4057qib7 15774 15 sibling sibling NN cord-005453-4057qib7 15774 16 donor donor NN cord-005453-4057qib7 15774 17 , , , cord-005453-4057qib7 15774 18 such such JJ cord-005453-4057qib7 15774 19 as as IN cord-005453-4057qib7 15774 20 unrelated unrelated JJ cord-005453-4057qib7 15774 21 donors donor NNS cord-005453-4057qib7 15774 22 ( ( -LRB- cord-005453-4057qib7 15774 23 URD URD NNP cord-005453-4057qib7 15774 24 ) ) -RRB- cord-005453-4057qib7 15774 25 and and CC cord-005453-4057qib7 15774 26 HLA HLA NNP cord-005453-4057qib7 15774 27 - - HYPH cord-005453-4057qib7 15774 28 mismatched mismatch VBN cord-005453-4057qib7 15774 29 family family NN cord-005453-4057qib7 15774 30 ( ( -LRB- cord-005453-4057qib7 15774 31 haploidentical haploidentical NNP cord-005453-4057qib7 15774 32 ) ) -RRB- cord-005453-4057qib7 15774 33 donors donor NNS cord-005453-4057qib7 15774 34 . . . cord-005453-4057qib7 15775 1 In in IN cord-005453-4057qib7 15775 2 order order NN cord-005453-4057qib7 15775 3 to to TO cord-005453-4057qib7 15775 4 discover discover VB cord-005453-4057qib7 15775 5 the the DT cord-005453-4057qib7 15775 6 exact exact JJ cord-005453-4057qib7 15775 7 role role NN cord-005453-4057qib7 15775 8 of of IN cord-005453-4057qib7 15775 9 transplantation transplantation NN cord-005453-4057qib7 15775 10 type type NN cord-005453-4057qib7 15775 11 , , , cord-005453-4057qib7 15775 12 there there EX cord-005453-4057qib7 15775 13 are be VBP cord-005453-4057qib7 15775 14 many many JJ cord-005453-4057qib7 15775 15 retrospective retrospective JJ cord-005453-4057qib7 15775 16 analysis analysis NN cord-005453-4057qib7 15775 17 , , , cord-005453-4057qib7 15775 18 which which WDT cord-005453-4057qib7 15775 19 compared compare VBD cord-005453-4057qib7 15775 20 these these DT cord-005453-4057qib7 15775 21 donor donor NN cord-005453-4057qib7 15775 22 sources source NNS cord-005453-4057qib7 15775 23 , , , cord-005453-4057qib7 15775 24 have have VBP cord-005453-4057qib7 15775 25 been be VBN cord-005453-4057qib7 15775 26 reported report VBN cord-005453-4057qib7 15775 27 . . . cord-005453-4057qib7 15776 1 Recent recent JJ cord-005453-4057qib7 15776 2 studies study NNS cord-005453-4057qib7 15776 3 showed show VBD cord-005453-4057qib7 15776 4 some some DT cord-005453-4057qib7 15776 5 promising promising JJ cord-005453-4057qib7 15776 6 results result NNS cord-005453-4057qib7 15776 7 of of IN cord-005453-4057qib7 15776 8 haploidentical haploidentical JJ cord-005453-4057qib7 15776 9 donor donor NN cord-005453-4057qib7 15776 10 transplantation transplantation NN cord-005453-4057qib7 15776 11 ( ( -LRB- cord-005453-4057qib7 15776 12 HIDT HIDT NNP cord-005453-4057qib7 15776 13 ) ) -RRB- cord-005453-4057qib7 15776 14 using use VBG cord-005453-4057qib7 15776 15 post post JJ cord-005453-4057qib7 15776 16 - - JJ cord-005453-4057qib7 15776 17 transplant transplant JJ cord-005453-4057qib7 15776 18 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 15776 19 in in IN cord-005453-4057qib7 15776 20 comparison comparison NN cord-005453-4057qib7 15776 21 with with IN cord-005453-4057qib7 15776 22 unrelated unrelated JJ cord-005453-4057qib7 15776 23 donor donor NN cord-005453-4057qib7 15776 24 . . . cord-005453-4057qib7 15777 1 The the DT cord-005453-4057qib7 15777 2 goal goal NN cord-005453-4057qib7 15777 3 of of IN cord-005453-4057qib7 15777 4 this this DT cord-005453-4057qib7 15777 5 study study NN cord-005453-4057qib7 15777 6 was be VBD cord-005453-4057qib7 15777 7 to to TO cord-005453-4057qib7 15777 8 compare compare VB cord-005453-4057qib7 15777 9 the the DT cord-005453-4057qib7 15777 10 outcome outcome NN cord-005453-4057qib7 15777 11 of of IN cord-005453-4057qib7 15777 12 allo allo NNP cord-005453-4057qib7 15777 13 - - HYPH cord-005453-4057qib7 15777 14 SCT SCT NNP cord-005453-4057qib7 15777 15 from from IN cord-005453-4057qib7 15777 16 haploidentical haploidentical JJ cord-005453-4057qib7 15777 17 versus versus IN cord-005453-4057qib7 15777 18 matched match VBN cord-005453-4057qib7 15777 19 unrelated unrelated JJ cord-005453-4057qib7 15777 20 ( ( -LRB- cord-005453-4057qib7 15777 21 MUD mud NN cord-005453-4057qib7 15777 22 10/10 10/10 CD cord-005453-4057qib7 15777 23 ) ) -RRB- cord-005453-4057qib7 15777 24 or or CC cord-005453-4057qib7 15777 25 mismatched mismatch VBN cord-005453-4057qib7 15777 26 unrelated unrelated JJ cord-005453-4057qib7 15777 27 donor donor NN cord-005453-4057qib7 15777 28 at at IN cord-005453-4057qib7 15777 29 a a DT cord-005453-4057qib7 15777 30 single single JJ cord-005453-4057qib7 15777 31 HLA HLA NNP cord-005453-4057qib7 15777 32 - - HYPH cord-005453-4057qib7 15777 33 locus locus NN cord-005453-4057qib7 15777 34 ( ( -LRB- cord-005453-4057qib7 15777 35 MMUD MMUD NNP cord-005453-4057qib7 15777 36 9/10 9/10 CD cord-005453-4057qib7 15777 37 ) ) -RRB- cord-005453-4057qib7 15777 38 for for IN cord-005453-4057qib7 15777 39 patients patient NNS cord-005453-4057qib7 15777 40 with with IN cord-005453-4057qib7 15777 41 acute acute JJ cord-005453-4057qib7 15777 42 leukemia leukemia NN cord-005453-4057qib7 15777 43 in in IN cord-005453-4057qib7 15777 44 remission remission NN cord-005453-4057qib7 15777 45 . . . cord-005453-4057qib7 15778 1 Methods method NNS cord-005453-4057qib7 15778 2 : : : cord-005453-4057qib7 15779 1 Ninety ninety CD cord-005453-4057qib7 15779 2 - - HYPH cord-005453-4057qib7 15779 3 six six CD cord-005453-4057qib7 15779 4 adult adult NN cord-005453-4057qib7 15779 5 ( ( -LRB- cord-005453-4057qib7 15779 6 18 18 CD cord-005453-4057qib7 15779 7 - - SYM cord-005453-4057qib7 15779 8 65 65 CD cord-005453-4057qib7 15779 9 years year NNS cord-005453-4057qib7 15779 10 ) ) -RRB- cord-005453-4057qib7 15779 11 patients patient NNS cord-005453-4057qib7 15779 12 with with IN cord-005453-4057qib7 15779 13 acute acute JJ cord-005453-4057qib7 15779 14 leukemia leukemia NN cord-005453-4057qib7 15779 15 in in IN cord-005453-4057qib7 15779 16 first first JJ cord-005453-4057qib7 15779 17 or or CC cord-005453-4057qib7 15779 18 second second JJ cord-005453-4057qib7 15779 19 remission remission NN cord-005453-4057qib7 15779 20 who who WP cord-005453-4057qib7 15779 21 underwent undergo VBD cord-005453-4057qib7 15779 22 allogeneic allogeneic JJ cord-005453-4057qib7 15779 23 transplantation transplantation NN cord-005453-4057qib7 15779 24 with with IN cord-005453-4057qib7 15779 25 a a DT cord-005453-4057qib7 15779 26 minimum minimum JJ cord-005453-4057qib7 15779 27 100 100 CD cord-005453-4057qib7 15779 28 days day NNS cord-005453-4057qib7 15779 29 follow follow NN cord-005453-4057qib7 15779 30 - - HYPH cord-005453-4057qib7 15779 31 up up NN cord-005453-4057qib7 15779 32 at at IN cord-005453-4057qib7 15779 33 Florence Florence NNP cord-005453-4057qib7 15779 34 Nightingale Nightingale NNP cord-005453-4057qib7 15779 35 Hospital Hospital NNP cord-005453-4057qib7 15779 36 Hematopoietic Hematopoietic NNP cord-005453-4057qib7 15779 37 Stem Stem NNP cord-005453-4057qib7 15779 38 Cell Cell NNP cord-005453-4057qib7 15779 39 Transplantation Transplantation NNP cord-005453-4057qib7 15779 40 Center Center NNP cord-005453-4057qib7 15779 41 between between IN cord-005453-4057qib7 15779 42 2011 2011 CD cord-005453-4057qib7 15779 43 and and CC cord-005453-4057qib7 15779 44 2017 2017 CD cord-005453-4057qib7 15779 45 were be VBD cord-005453-4057qib7 15779 46 included include VBN cord-005453-4057qib7 15779 47 in in IN cord-005453-4057qib7 15779 48 this this DT cord-005453-4057qib7 15779 49 study study NN cord-005453-4057qib7 15779 50 . . . cord-005453-4057qib7 15780 1 Patient patient JJ cord-005453-4057qib7 15780 2 characteristics characteristic NNS cord-005453-4057qib7 15780 3 and and CC cord-005453-4057qib7 15780 4 medical medical JJ cord-005453-4057qib7 15780 5 records record NNS cord-005453-4057qib7 15780 6 of of IN cord-005453-4057qib7 15780 7 all all DT cord-005453-4057qib7 15780 8 patients patient NNS cord-005453-4057qib7 15780 9 were be VBD cord-005453-4057qib7 15780 10 reviewed review VBN cord-005453-4057qib7 15780 11 retrospectively retrospectively RB cord-005453-4057qib7 15780 12 . . . cord-005453-4057qib7 15781 1 Thirty thirty CD cord-005453-4057qib7 15781 2 - - HYPH cord-005453-4057qib7 15781 3 eight eight CD cord-005453-4057qib7 15781 4 patients patient NNS cord-005453-4057qib7 15781 5 who who WP cord-005453-4057qib7 15781 6 received receive VBD cord-005453-4057qib7 15781 7 haploidentical haploidentical JJ cord-005453-4057qib7 15781 8 donor donor NN cord-005453-4057qib7 15781 9 transplantation transplantation NN cord-005453-4057qib7 15781 10 were be VBD cord-005453-4057qib7 15781 11 compared compare VBN cord-005453-4057qib7 15781 12 with with IN cord-005453-4057qib7 15781 13 23 23 CD cord-005453-4057qib7 15781 14 patients patient NNS cord-005453-4057qib7 15781 15 receiving receive VBG cord-005453-4057qib7 15781 16 a a DT cord-005453-4057qib7 15781 17 MUD mud NN cord-005453-4057qib7 15781 18 10/10 10/10 CD cord-005453-4057qib7 15781 19 and and CC cord-005453-4057qib7 15781 20 35 35 CD cord-005453-4057qib7 15781 21 receiving receive VBG cord-005453-4057qib7 15781 22 a a DT cord-005453-4057qib7 15781 23 MMUD MMUD NNP cord-005453-4057qib7 15781 24 9/10 9/10 CD cord-005453-4057qib7 15781 25 . . . cord-005453-4057qib7 15782 1 Patients patient NNS cord-005453-4057qib7 15782 2 who who WP cord-005453-4057qib7 15782 3 completed complete VBD cord-005453-4057qib7 15782 4 minimum minimum JJ cord-005453-4057qib7 15782 5 100 100 CD cord-005453-4057qib7 15782 6 days day NNS cord-005453-4057qib7 15782 7 post post NN cord-005453-4057qib7 15782 8 - - NN cord-005453-4057qib7 15782 9 transplantation transplantation JJ cord-005453-4057qib7 15782 10 follow follow NN cord-005453-4057qib7 15782 11 - - HYPH cord-005453-4057qib7 15782 12 up up NN cord-005453-4057qib7 15782 13 were be VBD cord-005453-4057qib7 15782 14 identified identify VBN cord-005453-4057qib7 15782 15 as as IN cord-005453-4057qib7 15782 16 eligible eligible JJ cord-005453-4057qib7 15782 17 for for IN cord-005453-4057qib7 15782 18 survival survival NN cord-005453-4057qib7 15782 19 analysis analysis NN cord-005453-4057qib7 15782 20 . . . cord-005453-4057qib7 15783 1 Results result NNS cord-005453-4057qib7 15783 2 : : : cord-005453-4057qib7 15784 1 The the DT cord-005453-4057qib7 15784 2 characteristics characteristic NNS cord-005453-4057qib7 15784 3 of of IN cord-005453-4057qib7 15784 4 the the DT cord-005453-4057qib7 15784 5 patients patient NNS cord-005453-4057qib7 15784 6 and and CC cord-005453-4057qib7 15784 7 transplant transplant NN cord-005453-4057qib7 15784 8 donors donor NNS cord-005453-4057qib7 15784 9 in in IN cord-005453-4057qib7 15784 10 this this DT cord-005453-4057qib7 15784 11 study study NN cord-005453-4057qib7 15784 12 are be VBP cord-005453-4057qib7 15784 13 summarized summarize VBN cord-005453-4057qib7 15784 14 in in IN cord-005453-4057qib7 15784 15 Table Table NNP cord-005453-4057qib7 15784 16 1 1 CD cord-005453-4057qib7 15784 17 . . . cord-005453-4057qib7 15785 1 Median median JJ cord-005453-4057qib7 15785 2 age age NN cord-005453-4057qib7 15785 3 of of IN cord-005453-4057qib7 15785 4 patients patient NNS cord-005453-4057qib7 15785 5 was be VBD cord-005453-4057qib7 15785 6 39.4±14 39.4±14 CD cord-005453-4057qib7 15785 7 years year NNS cord-005453-4057qib7 15785 8 . . . cord-005453-4057qib7 15786 1 Proportion proportion NN cord-005453-4057qib7 15786 2 of of IN cord-005453-4057qib7 15786 3 male male JJ cord-005453-4057qib7 15786 4 patients patient NNS cord-005453-4057qib7 15786 5 was be VBD cord-005453-4057qib7 15786 6 39.1 39.1 CD cord-005453-4057qib7 15786 7 % % NN cord-005453-4057qib7 15786 8 , , , cord-005453-4057qib7 15786 9 74.2 74.2 CD cord-005453-4057qib7 15786 10 % % NN cord-005453-4057qib7 15786 11 and and CC cord-005453-4057qib7 15786 12 57.8 57.8 CD cord-005453-4057qib7 15786 13 % % NN cord-005453-4057qib7 15786 14 for for IN cord-005453-4057qib7 15786 15 MUD mud NN cord-005453-4057qib7 15786 16 10/ 10/ CD cord-005453-4057qib7 15786 17 10 10 CD cord-005453-4057qib7 15786 18 , , , cord-005453-4057qib7 15786 19 MMUD MMUD NNP cord-005453-4057qib7 15786 20 9/10 9/10 CD cord-005453-4057qib7 15786 21 and and CC cord-005453-4057qib7 15786 22 HIDT hidt JJ cord-005453-4057qib7 15786 23 groups group NNS cord-005453-4057qib7 15786 24 , , , cord-005453-4057qib7 15786 25 respectively respectively RB cord-005453-4057qib7 15786 26 , , , cord-005453-4057qib7 15786 27 which which WDT cord-005453-4057qib7 15786 28 is be VBZ cord-005453-4057qib7 15786 29 significantly significantly RB cord-005453-4057qib7 15786 30 different different JJ cord-005453-4057qib7 15786 31 ( ( -LRB- cord-005453-4057qib7 15786 32 p=0.02 p=0.02 NN cord-005453-4057qib7 15786 33 ) ) -RRB- cord-005453-4057qib7 15786 34 . . . cord-005453-4057qib7 15787 1 The the DT cord-005453-4057qib7 15787 2 other other JJ cord-005453-4057qib7 15787 3 baseline baseline JJ cord-005453-4057qib7 15787 4 factors factor NNS cord-005453-4057qib7 15787 5 were be VBD cord-005453-4057qib7 15787 6 similar similar JJ cord-005453-4057qib7 15787 7 , , , cord-005453-4057qib7 15787 8 including include VBG cord-005453-4057qib7 15787 9 patient patient JJ cord-005453-4057qib7 15787 10 age age NN cord-005453-4057qib7 15787 11 , , , cord-005453-4057qib7 15787 12 donor donor NN cord-005453-4057qib7 15787 13 age age NN cord-005453-4057qib7 15787 14 , , , cord-005453-4057qib7 15787 15 recipient recipient NN cord-005453-4057qib7 15787 16 cytomegalovirus cytomegalovirus NN cord-005453-4057qib7 15787 17 ( ( -LRB- cord-005453-4057qib7 15787 18 CMV CMV NNP cord-005453-4057qib7 15787 19 ) ) -RRB- cord-005453-4057qib7 15787 20 status status NN cord-005453-4057qib7 15787 21 , , , cord-005453-4057qib7 15787 22 donor donor NN cord-005453-4057qib7 15787 23 CMV cmv NN cord-005453-4057qib7 15787 24 status status NN cord-005453-4057qib7 15787 25 , , , cord-005453-4057qib7 15787 26 graft graft NN cord-005453-4057qib7 15787 27 versus versus IN cord-005453-4057qib7 15787 28 host host NN cord-005453-4057qib7 15787 29 disease disease NN cord-005453-4057qib7 15787 30 incidence incidence NN cord-005453-4057qib7 15787 31 , , , cord-005453-4057qib7 15787 32 median median JJ cord-005453-4057qib7 15787 33 neutrophil neutrophil NN cord-005453-4057qib7 15787 34 and and CC cord-005453-4057qib7 15787 35 platelet platelet NN cord-005453-4057qib7 15787 36 engraftment engraftment NN cord-005453-4057qib7 15787 37 times time NNS cord-005453-4057qib7 15787 38 and and CC cord-005453-4057qib7 15787 39 disease disease NN cord-005453-4057qib7 15787 40 status status NN cord-005453-4057qib7 15787 41 at at IN cord-005453-4057qib7 15787 42 post post JJ cord-005453-4057qib7 15787 43 - - JJ cord-005453-4057qib7 15787 44 transplant transplant NN cord-005453-4057qib7 15787 45 100 100 CD cord-005453-4057qib7 15787 46 th th XX cord-005453-4057qib7 15787 47 day day NN cord-005453-4057qib7 15787 48 . . . cord-005453-4057qib7 15788 1 No no DT cord-005453-4057qib7 15788 2 significant significant JJ cord-005453-4057qib7 15788 3 difference difference NN cord-005453-4057qib7 15788 4 was be VBD cord-005453-4057qib7 15788 5 identified identify VBN cord-005453-4057qib7 15788 6 in in IN cord-005453-4057qib7 15788 7 survival survival NN cord-005453-4057qib7 15788 8 analysis analysis NN cord-005453-4057qib7 15788 9 among among IN cord-005453-4057qib7 15788 10 the the DT cord-005453-4057qib7 15788 11 MUD MUD NNP cord-005453-4057qib7 15788 12 10/10 10/10 CD cord-005453-4057qib7 15788 13 , , , cord-005453-4057qib7 15788 14 MMUD MMUD NNP cord-005453-4057qib7 15788 15 9/10 9/10 CD cord-005453-4057qib7 15788 16 and and CC cord-005453-4057qib7 15788 17 HIDT hidt JJ cord-005453-4057qib7 15788 18 groups group NNS cord-005453-4057qib7 15788 19 , , , cord-005453-4057qib7 15788 20 even even RB cord-005453-4057qib7 15788 21 if if IN cord-005453-4057qib7 15788 22 they -PRON- PRP cord-005453-4057qib7 15788 23 were be VBD cord-005453-4057qib7 15788 24 classified classify VBN cord-005453-4057qib7 15788 25 according accord VBG cord-005453-4057qib7 15788 26 to to IN cord-005453-4057qib7 15788 27 primary primary JJ cord-005453-4057qib7 15788 28 disease disease NN cord-005453-4057qib7 15788 29 ( ( -LRB- cord-005453-4057qib7 15788 30 AML AML NNP cord-005453-4057qib7 15788 31 vs vs IN cord-005453-4057qib7 15788 32 ALL all DT cord-005453-4057qib7 15788 33 ) ) -RRB- cord-005453-4057qib7 15788 34 and and CC cord-005453-4057qib7 15788 35 pre pre JJ cord-005453-4057qib7 15788 36 - - JJ cord-005453-4057qib7 15788 37 transplant transplant JJ cord-005453-4057qib7 15788 38 disease disease NN cord-005453-4057qib7 15788 39 status status NN cord-005453-4057qib7 15788 40 ( ( -LRB- cord-005453-4057qib7 15788 41 CR1 CR1 NNP cord-005453-4057qib7 15788 42 vs vs IN cord-005453-4057qib7 15788 43 CR2 CR2 NNP cord-005453-4057qib7 15788 44 ) ) -RRB- cord-005453-4057qib7 15788 45 . . . cord-005453-4057qib7 15789 1 Also also RB cord-005453-4057qib7 15789 2 , , , cord-005453-4057qib7 15789 3 donor donor NN cord-005453-4057qib7 15789 4 CMV cmv NN cord-005453-4057qib7 15789 5 status status NN cord-005453-4057qib7 15789 6 ( ( -LRB- cord-005453-4057qib7 15789 7 CMV CMV NNP cord-005453-4057qib7 15789 8 IgG igg NN cord-005453-4057qib7 15789 9 positivity positivity NN cord-005453-4057qib7 15789 10 or or CC cord-005453-4057qib7 15789 11 negativity negativity NN cord-005453-4057qib7 15789 12 ) ) -RRB- cord-005453-4057qib7 15789 13 was be VBD cord-005453-4057qib7 15789 14 not not RB cord-005453-4057qib7 15789 15 an an DT cord-005453-4057qib7 15789 16 important important JJ cord-005453-4057qib7 15789 17 factor factor NN cord-005453-4057qib7 15789 18 on on IN cord-005453-4057qib7 15789 19 survival survival NN cord-005453-4057qib7 15789 20 analysis analysis NN cord-005453-4057qib7 15789 21 when when WRB cord-005453-4057qib7 15789 22 compared compare VBN cord-005453-4057qib7 15789 23 between between IN cord-005453-4057qib7 15789 24 these these DT cord-005453-4057qib7 15789 25 three three CD cord-005453-4057qib7 15789 26 groups group NNS cord-005453-4057qib7 15789 27 ( ( -LRB- cord-005453-4057qib7 15789 28 p=0.406).Conclusions p=0.406).conclusion NNS cord-005453-4057qib7 15789 29 : : : cord-005453-4057qib7 15789 30 In in IN cord-005453-4057qib7 15789 31 our -PRON- PRP$ cord-005453-4057qib7 15789 32 study study NN cord-005453-4057qib7 15789 33 population population NN cord-005453-4057qib7 15789 34 , , , cord-005453-4057qib7 15789 35 clinical clinical JJ cord-005453-4057qib7 15789 36 outcomes outcome NNS cord-005453-4057qib7 15789 37 of of IN cord-005453-4057qib7 15789 38 HIDT hidt JJ cord-005453-4057qib7 15789 39 patients patient NNS cord-005453-4057qib7 15789 40 were be VBD cord-005453-4057qib7 15789 41 inferior inferior JJ cord-005453-4057qib7 15789 42 to to TO cord-005453-4057qib7 15789 43 MUD mud NN cord-005453-4057qib7 15789 44 10/10 10/10 CD cord-005453-4057qib7 15789 45 and and CC cord-005453-4057qib7 15789 46 MMUD MMUD NNP cord-005453-4057qib7 15789 47 9/10 9/10 CD cord-005453-4057qib7 15789 48 groups group NNS cord-005453-4057qib7 15789 49 . . . cord-005453-4057qib7 15790 1 When when WRB cord-005453-4057qib7 15790 2 choosing choose VBG cord-005453-4057qib7 15790 3 an an DT cord-005453-4057qib7 15790 4 alternative alternative JJ cord-005453-4057qib7 15790 5 donor donor NN cord-005453-4057qib7 15790 6 for for IN cord-005453-4057qib7 15790 7 patients patient NNS cord-005453-4057qib7 15790 8 without without IN cord-005453-4057qib7 15790 9 an an DT cord-005453-4057qib7 15790 10 available available JJ cord-005453-4057qib7 15790 11 HLA HLA NNP cord-005453-4057qib7 15790 12 - - HYPH cord-005453-4057qib7 15790 13 matched match VBN cord-005453-4057qib7 15790 14 sibling sibling NN cord-005453-4057qib7 15790 15 , , , cord-005453-4057qib7 15790 16 urgency urgency NN cord-005453-4057qib7 15790 17 of of IN cord-005453-4057qib7 15790 18 transplantation transplantation NN cord-005453-4057qib7 15790 19 and and CC cord-005453-4057qib7 15790 20 host host NN cord-005453-4057qib7 15790 21 / / SYM cord-005453-4057qib7 15790 22 donor donor NN cord-005453-4057qib7 15790 23 features feature NNS cord-005453-4057qib7 15790 24 should should MD cord-005453-4057qib7 15790 25 be be VB cord-005453-4057qib7 15790 26 considered consider VBN cord-005453-4057qib7 15790 27 . . . cord-005453-4057qib7 15791 1 We -PRON- PRP cord-005453-4057qib7 15791 2 believe believe VBP cord-005453-4057qib7 15791 3 that that IN cord-005453-4057qib7 15791 4 HIDT HIDT NNP cord-005453-4057qib7 15791 5 might may MD cord-005453-4057qib7 15791 6 be be VB cord-005453-4057qib7 15791 7 a a DT cord-005453-4057qib7 15791 8 feasible feasible JJ cord-005453-4057qib7 15791 9 alternative alternative JJ cord-005453-4057qib7 15791 10 choice choice NN cord-005453-4057qib7 15791 11 in in IN cord-005453-4057qib7 15791 12 this this DT cord-005453-4057qib7 15791 13 subset subset NN cord-005453-4057qib7 15791 14 of of IN cord-005453-4057qib7 15791 15 patients patient NNS cord-005453-4057qib7 15791 16 . . . cord-005453-4057qib7 15792 1 Disclosure disclosure NN cord-005453-4057qib7 15792 2 : : : cord-005453-4057qib7 15792 3 Nothing nothing NN cord-005453-4057qib7 15792 4 to to TO cord-005453-4057qib7 15792 5 declare declare VB cord-005453-4057qib7 15792 6 P673 P673 NNP cord-005453-4057qib7 15792 7 G G NNP cord-005453-4057qib7 15792 8 - - HYPH cord-005453-4057qib7 15792 9 CSF csf NN cord-005453-4057qib7 15792 10 primed prime VBN cord-005453-4057qib7 15792 11 bone bone NN cord-005453-4057qib7 15792 12 marrow marrow NN cord-005453-4057qib7 15792 13 in in IN cord-005453-4057qib7 15792 14 HLA HLA NNP cord-005453-4057qib7 15792 15 - - HYPH cord-005453-4057qib7 15792 16 haploidentical haploidentical JJ cord-005453-4057qib7 15792 17 transplantation transplantation NN cord-005453-4057qib7 15792 18 using use VBG cord-005453-4057qib7 15792 19 post post JJ cord-005453-4057qib7 15792 20 - - NN cord-005453-4057qib7 15792 21 transplantation transplantation JJ cord-005453-4057qib7 15792 22 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 15792 23 ( ( -LRB- cord-005453-4057qib7 15792 24 PTCY PTCY NNP cord-005453-4057qib7 15792 25 ) ) -RRB- cord-005453-4057qib7 15792 26 could could MD cord-005453-4057qib7 15792 27 promote promote VB cord-005453-4057qib7 15792 28 tolerance tolerance NN cord-005453-4057qib7 15792 29 and and CC cord-005453-4057qib7 15792 30 further further RB cord-005453-4057qib7 15792 31 reduce reduce VB cord-005453-4057qib7 15792 32 risk risk NN cord-005453-4057qib7 15792 33 of of IN cord-005453-4057qib7 15792 34 GVHD GVHD NNP cord-005453-4057qib7 15792 35 Nadira Nadira NNP cord-005453-4057qib7 15792 36 Durakovic Durakovic NNP cord-005453-4057qib7 15792 37 1,2 1,2 CD cord-005453-4057qib7 15792 38 , , , cord-005453-4057qib7 15792 39 Zinaida Zinaida NNP cord-005453-4057qib7 15792 40 Perić Perić NNP cord-005453-4057qib7 15792 41 1,2 1,2 CD cord-005453-4057qib7 15792 42 , , , cord-005453-4057qib7 15792 43 Lana Lana NNP cord-005453-4057qib7 15792 44 Desnica Desnica NNP cord-005453-4057qib7 15792 45 2 2 CD cord-005453-4057qib7 15792 46 , , , cord-005453-4057qib7 15792 47 Ranka Ranka NNP cord-005453-4057qib7 15792 48 Serventi Serventi NNP cord-005453-4057qib7 15792 49 - - HYPH cord-005453-4057qib7 15792 50 Seiwerth Seiwerth NNP cord-005453-4057qib7 15792 51 2 2 CD cord-005453-4057qib7 15792 52 , , , cord-005453-4057qib7 15792 53 Mirta Mirta NNP cord-005453-4057qib7 15792 54 Mikulić Mikulić NNP cord-005453-4057qib7 15792 55 2 2 CD cord-005453-4057qib7 15792 56 , , , cord-005453-4057qib7 15792 57 Brian Brian NNP cord-005453-4057qib7 15792 58 Melamed Melamed NNP cord-005453-4057qib7 15792 59 3 3 CD cord-005453-4057qib7 15792 60 , , , cord-005453-4057qib7 15792 61 Alen Alen NNP cord-005453-4057qib7 15792 62 Ostojić Ostojić NNP cord-005453-4057qib7 15792 63 2 2 CD cord-005453-4057qib7 15792 64 , , , cord-005453-4057qib7 15792 65 Dražen Dražen NNP cord-005453-4057qib7 15792 66 Pulanić Pulanić NNP cord-005453-4057qib7 15792 67 1,2 1,2 CD cord-005453-4057qib7 15792 68 , , , cord-005453-4057qib7 15792 69 Pavle Pavle NNP cord-005453-4057qib7 15792 70 Rončević Rončević NNP cord-005453-4057qib7 15792 71 2 2 CD cord-005453-4057qib7 15792 72 , , , cord-005453-4057qib7 15792 73 Zorana Zorana NNP cord-005453-4057qib7 15792 74 Grubić Grubić NNP cord-005453-4057qib7 15792 75 2 2 CD cord-005453-4057qib7 15792 76 , , , cord-005453-4057qib7 15792 77 Radovan Radovan NNP cord-005453-4057qib7 15792 78 Vrhovac Vrhovac NNP cord-005453-4057qib7 15792 79 1,2 1,2 CD cord-005453-4057qib7 15792 80 implementation implementation NN cord-005453-4057qib7 15792 81 , , , cord-005453-4057qib7 15792 82 development development NN cord-005453-4057qib7 15792 83 , , , cord-005453-4057qib7 15792 84 and and CC cord-005453-4057qib7 15792 85 coordination coordination NN cord-005453-4057qib7 15792 86 of of IN cord-005453-4057qib7 15792 87 unique unique JJ cord-005453-4057qib7 15792 88 quality quality NN cord-005453-4057qib7 15792 89 management management NN cord-005453-4057qib7 15792 90 systems system NNS cord-005453-4057qib7 15792 91 with with IN cord-005453-4057qib7 15792 92 evaluation evaluation NN cord-005453-4057qib7 15792 93 audits audits NN cord-005453-4057qib7 15792 94 , , , cord-005453-4057qib7 15792 95 intrahospital intrahospital NNP cord-005453-4057qib7 15792 96 and and CC cord-005453-4057qib7 15792 97 international international JJ cord-005453-4057qib7 15792 98 accreditation accreditation NN cord-005453-4057qib7 15792 99 and and CC cord-005453-4057qib7 15792 100 certification certification NN cord-005453-4057qib7 15792 101 processes process NNS cord-005453-4057qib7 15792 102 . . . cord-005453-4057qib7 15793 1 Quality quality NN cord-005453-4057qib7 15793 2 of of IN cord-005453-4057qib7 15793 3 health health NN cord-005453-4057qib7 15793 4 care care NN cord-005453-4057qib7 15793 5 is be VBZ cord-005453-4057qib7 15793 6 a a DT cord-005453-4057qib7 15793 7 major major JJ cord-005453-4057qib7 15793 8 focus focus NN cord-005453-4057qib7 15793 9 for for IN cord-005453-4057qib7 15793 10 providers provider NNS cord-005453-4057qib7 15793 11 , , , cord-005453-4057qib7 15793 12 patients patient NNS cord-005453-4057qib7 15793 13 , , , cord-005453-4057qib7 15793 14 and and CC cord-005453-4057qib7 15793 15 accreditors accreditor NNS cord-005453-4057qib7 15793 16 ; ; : cord-005453-4057qib7 15793 17 so so CC cord-005453-4057qib7 15793 18 , , , cord-005453-4057qib7 15793 19 in in IN cord-005453-4057qib7 15793 20 this this DT cord-005453-4057qib7 15793 21 study study NN cord-005453-4057qib7 15793 22 , , , cord-005453-4057qib7 15793 23 we -PRON- PRP cord-005453-4057qib7 15793 24 aim aim VBP cord-005453-4057qib7 15793 25 to to TO cord-005453-4057qib7 15793 26 compare compare VB cord-005453-4057qib7 15793 27 the the DT cord-005453-4057qib7 15793 28 quality quality NN cord-005453-4057qib7 15793 29 of of IN cord-005453-4057qib7 15793 30 BM BM NNP cord-005453-4057qib7 15793 31 harvested harvest VBN cord-005453-4057qib7 15793 32 at at IN cord-005453-4057qib7 15793 33 IPO IPO NNP cord-005453-4057qib7 15793 34 - - HYPH cord-005453-4057qib7 15793 35 Collection Collection NNP cord-005453-4057qib7 15793 36 Centre Centre NNP cord-005453-4057qib7 15793 37 ( ( -LRB- cord-005453-4057qib7 15793 38 ICC ICC NNP cord-005453-4057qib7 15793 39 ) ) -RRB- cord-005453-4057qib7 15793 40 with with IN cord-005453-4057qib7 15793 41 the the DT cord-005453-4057qib7 15793 42 quality quality NN cord-005453-4057qib7 15793 43 of of IN cord-005453-4057qib7 15793 44 BM BM NNP cord-005453-4057qib7 15793 45 received receive VBN cord-005453-4057qib7 15793 46 from from IN cord-005453-4057qib7 15793 47 External External NNP cord-005453-4057qib7 15793 48 Collection Collection NNP cord-005453-4057qib7 15793 49 Centres Centres NNPS cord-005453-4057qib7 15793 50 ( ( -LRB- cord-005453-4057qib7 15793 51 ECC ECC NNP cord-005453-4057qib7 15793 52 ) ) -RRB- cord-005453-4057qib7 15793 53 during during IN cord-005453-4057qib7 15793 54 these these DT cord-005453-4057qib7 15793 55 6 6 CD cord-005453-4057qib7 15793 56 last last JJ cord-005453-4057qib7 15793 57 years year NNS cord-005453-4057qib7 15793 58 . . . cord-005453-4057qib7 15794 1 Methods method NNS cord-005453-4057qib7 15794 2 : : : cord-005453-4057qib7 15795 1 This this DT cord-005453-4057qib7 15795 2 retrospective retrospective JJ cord-005453-4057qib7 15795 3 evaluation evaluation NN cord-005453-4057qib7 15795 4 included include VBD cord-005453-4057qib7 15795 5 the the DT cord-005453-4057qib7 15795 6 number number NN cord-005453-4057qib7 15795 7 of of IN cord-005453-4057qib7 15795 8 total total JJ cord-005453-4057qib7 15795 9 nucleated nucleated JJ cord-005453-4057qib7 15795 10 cells cell NNS cord-005453-4057qib7 15795 11 ( ( -LRB- cord-005453-4057qib7 15795 12 TNC TNC NNP cord-005453-4057qib7 15795 13 ) ) -RRB- cord-005453-4057qib7 15795 14 requested request VBN cord-005453-4057qib7 15795 15 by by IN cord-005453-4057qib7 15795 16 the the DT cord-005453-4057qib7 15795 17 Transplant Transplant NNP cord-005453-4057qib7 15795 18 Centre Centre NNP cord-005453-4057qib7 15795 19 , , , cord-005453-4057qib7 15795 20 the the DT cord-005453-4057qib7 15795 21 TNC TNC NNP cord-005453-4057qib7 15795 22 collected collect VBD cord-005453-4057qib7 15795 23 , , , cord-005453-4057qib7 15795 24 and and CC cord-005453-4057qib7 15795 25 the the DT cord-005453-4057qib7 15795 26 results result NNS cord-005453-4057qib7 15795 27 of of IN cord-005453-4057qib7 15795 28 BM BM NNP cord-005453-4057qib7 15795 29 microbiological microbiological JJ cord-005453-4057qib7 15795 30 analysis analysis NN cord-005453-4057qib7 15795 31 performed perform VBN cord-005453-4057qib7 15795 32 ; ; : cord-005453-4057qib7 15795 33 donor donor NN cord-005453-4057qib7 15795 34 age age NN cord-005453-4057qib7 15795 35 , , , cord-005453-4057qib7 15795 36 weight weight NN cord-005453-4057qib7 15795 37 and and CC cord-005453-4057qib7 15795 38 infectious infectious JJ cord-005453-4057qib7 15795 39 disease disease NN cord-005453-4057qib7 15795 40 markers marker NNS cord-005453-4057qib7 15795 41 ( ( -LRB- cord-005453-4057qib7 15795 42 IDM IDM NNP cord-005453-4057qib7 15795 43 ) ) -RRB- cord-005453-4057qib7 15795 44 ; ; , cord-005453-4057qib7 15795 45 patient patient JJ cord-005453-4057qib7 15795 46 demographics demographic NNS cord-005453-4057qib7 15795 47 and and CC cord-005453-4057qib7 15795 48 diagnosis diagnosis NN cord-005453-4057qib7 15795 49 . . . cord-005453-4057qib7 15796 1 BM BM NNP cord-005453-4057qib7 15796 2 collection collection NN cord-005453-4057qib7 15796 3 technique technique NN cord-005453-4057qib7 15796 4 in in IN cord-005453-4057qib7 15796 5 use use NN cord-005453-4057qib7 15796 6 at at IN cord-005453-4057qib7 15796 7 ICC ICC NNP cord-005453-4057qib7 15796 8 was be VBD cord-005453-4057qib7 15796 9 validated validate VBN cord-005453-4057qib7 15796 10 according accord VBG cord-005453-4057qib7 15796 11 to to IN cord-005453-4057qib7 15796 12 JACIE JACIE NNP cord-005453-4057qib7 15796 13 Standards Standards NNP cord-005453-4057qib7 15796 14 . . . cord-005453-4057qib7 15797 1 We -PRON- PRP cord-005453-4057qib7 15797 2 consider consider VBP cord-005453-4057qib7 15797 3 successful successful JJ cord-005453-4057qib7 15797 4 a a DT cord-005453-4057qib7 15797 5 collection collection NN cord-005453-4057qib7 15797 6 ( ( -LRB- cord-005453-4057qib7 15797 7 SC SC NNP cord-005453-4057qib7 15797 8 ) ) -RRB- cord-005453-4057qib7 15797 9 with with IN cord-005453-4057qib7 15797 10 TNC TNC NNP cord-005453-4057qib7 15797 11 between between IN cord-005453-4057qib7 15797 12 75 75 CD cord-005453-4057qib7 15797 13 and and CC cord-005453-4057qib7 15797 14 125 125 CD cord-005453-4057qib7 15797 15 % % NN cord-005453-4057qib7 15797 16 of of IN cord-005453-4057qib7 15797 17 the the DT cord-005453-4057qib7 15797 18 requested request VBN cord-005453-4057qib7 15797 19 value value NN cord-005453-4057qib7 15797 20 , , , cord-005453-4057qib7 15797 21 unsuccessful unsuccessful JJ cord-005453-4057qib7 15797 22 ( ( -LRB- cord-005453-4057qib7 15797 23 UC UC NNP cord-005453-4057qib7 15797 24 ) ) -RRB- cord-005453-4057qib7 15798 1 if if IN cord-005453-4057qib7 15798 2 lower low JJR cord-005453-4057qib7 15798 3 than than IN cord-005453-4057qib7 15798 4 75 75 CD cord-005453-4057qib7 15798 5 % % NN cord-005453-4057qib7 15798 6 and and CC cord-005453-4057qib7 15798 7 outstanding outstanding JJ cord-005453-4057qib7 15798 8 ( ( -LRB- cord-005453-4057qib7 15798 9 OC OC NNP cord-005453-4057qib7 15798 10 ) ) -RRB- cord-005453-4057qib7 15798 11 if if IN cord-005453-4057qib7 15798 12 over over IN cord-005453-4057qib7 15798 13 125%.Results 125%.results CD cord-005453-4057qib7 15798 14 : : : cord-005453-4057qib7 15798 15 A a DT cord-005453-4057qib7 15798 16 total total NN cord-005453-4057qib7 15798 17 of of IN cord-005453-4057qib7 15798 18 106 106 CD cord-005453-4057qib7 15798 19 BM BM NNP cord-005453-4057qib7 15798 20 was be VBD cord-005453-4057qib7 15798 21 collected collect VBN cord-005453-4057qib7 15798 22 , , , cord-005453-4057qib7 15798 23 99 99 CD cord-005453-4057qib7 15798 24 for for IN cord-005453-4057qib7 15798 25 allogenic allogenic JJ cord-005453-4057qib7 15798 26 ( ( -LRB- cord-005453-4057qib7 15798 27 75 75 CD cord-005453-4057qib7 15798 28 unrelated unrelated JJ cord-005453-4057qib7 15798 29 ) ) -RRB- cord-005453-4057qib7 15798 30 and and CC cord-005453-4057qib7 15798 31 seven seven CD cord-005453-4057qib7 15798 32 for for IN cord-005453-4057qib7 15798 33 autologous autologous JJ cord-005453-4057qib7 15798 34 transplant transplant NN cord-005453-4057qib7 15798 35 ; ; : cord-005453-4057qib7 15798 36 21 21 CD cord-005453-4057qib7 15798 37 unrelated unrelated JJ cord-005453-4057qib7 15798 38 BM BM NNP cord-005453-4057qib7 15798 39 were be VBD cord-005453-4057qib7 15798 40 received receive VBN cord-005453-4057qib7 15798 41 from from IN cord-005453-4057qib7 15798 42 ECC ECC NNP cord-005453-4057qib7 15798 43 ( ( -LRB- cord-005453-4057qib7 15798 44 nine nine CD cord-005453-4057qib7 15798 45 from from IN cord-005453-4057qib7 15798 46 Germany Germany NNP cord-005453-4057qib7 15798 47 , , , cord-005453-4057qib7 15798 48 seven seven CD cord-005453-4057qib7 15798 49 from from IN cord-005453-4057qib7 15798 50 USA USA NNP cord-005453-4057qib7 15798 51 and and CC cord-005453-4057qib7 15798 52 five five CD cord-005453-4057qib7 15798 53 from from IN cord-005453-4057qib7 15798 54 Portugal Portugal NNP cord-005453-4057qib7 15798 55 ) ) -RRB- cord-005453-4057qib7 15798 56 . . . cord-005453-4057qib7 15799 1 Patient patient JJ cord-005453-4057qib7 15799 2 main main JJ cord-005453-4057qib7 15799 3 diagnosis diagnosis NN cord-005453-4057qib7 15799 4 were be VBD cord-005453-4057qib7 15799 5 severe severe JJ cord-005453-4057qib7 15799 6 aplastic aplastic JJ cord-005453-4057qib7 15799 7 anaemia anaemia NN cord-005453-4057qib7 15799 8 ( ( -LRB- cord-005453-4057qib7 15799 9 n=28 n=28 NN cord-005453-4057qib7 15799 10 ) ) -RRB- cord-005453-4057qib7 15799 11 , , , cord-005453-4057qib7 15799 12 acute acute JJ cord-005453-4057qib7 15799 13 myeloblastic myeloblastic JJ cord-005453-4057qib7 15799 14 leukaemia leukaemia NN cord-005453-4057qib7 15799 15 ( ( -LRB- cord-005453-4057qib7 15799 16 n=20 n=20 NNP cord-005453-4057qib7 15799 17 ) ) -RRB- cord-005453-4057qib7 15799 18 , , , cord-005453-4057qib7 15799 19 and and CC cord-005453-4057qib7 15799 20 acute acute JJ cord-005453-4057qib7 15799 21 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 15799 22 leukaemia leukaemia NN cord-005453-4057qib7 15799 23 ( ( -LRB- cord-005453-4057qib7 15799 24 n=15 n=15 NNP cord-005453-4057qib7 15799 25 ) ) -RRB- cord-005453-4057qib7 15799 26 . . . cord-005453-4057qib7 15800 1 Donors donor NNS cord-005453-4057qib7 15800 2 IDM IDM NNP cord-005453-4057qib7 15800 3 were be VBD cord-005453-4057qib7 15800 4 all all DT cord-005453-4057qib7 15800 5 negative negative JJ cord-005453-4057qib7 15800 6 and and CC cord-005453-4057qib7 15800 7 nonreactive nonreactive JJ cord-005453-4057qib7 15800 8 . . . cord-005453-4057qib7 15801 1 Mean mean JJ cord-005453-4057qib7 15801 2 age age NN cord-005453-4057qib7 15801 3 ( ( -LRB- cord-005453-4057qib7 15801 4 ±standard ±standard IN cord-005453-4057qib7 15801 5 deviation deviation NN cord-005453-4057qib7 15801 6 , , , cord-005453-4057qib7 15801 7 SD SD NNP cord-005453-4057qib7 15801 8 ) ) -RRB- cord-005453-4057qib7 15801 9 was be VBD cord-005453-4057qib7 15801 10 33 33 CD cord-005453-4057qib7 15801 11 ( ( -LRB- cord-005453-4057qib7 15801 12 ±13.2 ±13.2 CD cord-005453-4057qib7 15801 13 ) ) -RRB- cord-005453-4057qib7 15801 14 and and CC cord-005453-4057qib7 15801 15 31 31 CD cord-005453-4057qib7 15801 16 ( ( -LRB- cord-005453-4057qib7 15801 17 ±9.3 ±9.3 NNP cord-005453-4057qib7 15801 18 ) ) -RRB- cord-005453-4057qib7 15801 19 years year NNS cord-005453-4057qib7 15801 20 for for IN cord-005453-4057qib7 15801 21 ICC ICC NNP cord-005453-4057qib7 15801 22 and and CC cord-005453-4057qib7 15801 23 ECC ECC NNP cord-005453-4057qib7 15801 24 donors donor NNS cord-005453-4057qib7 15801 25 , , , cord-005453-4057qib7 15801 26 respectively respectively RB cord-005453-4057qib7 15801 27 . . . cord-005453-4057qib7 15802 1 At at IN cord-005453-4057qib7 15802 2 ICC ICC NNP cord-005453-4057qib7 15802 3 , , , cord-005453-4057qib7 15802 4 we -PRON- PRP cord-005453-4057qib7 15802 5 were be VBD cord-005453-4057qib7 15802 6 asked ask VBN cord-005453-4057qib7 15802 7 to to TO cord-005453-4057qib7 15802 8 collect collect VB cord-005453-4057qib7 15802 9 an an DT cord-005453-4057qib7 15802 10 average average NN cord-005453-4057qib7 15802 11 ( ( -LRB- cord-005453-4057qib7 15802 12 ±SD ±sd RB cord-005453-4057qib7 15802 13 ) ) -RRB- cord-005453-4057qib7 15802 14 of of IN cord-005453-4057qib7 15802 15 221.7 221.7 CD cord-005453-4057qib7 15802 16 * * NFP cord-005453-4057qib7 15802 17 10 10 CD cord-005453-4057qib7 15802 18 8 8 CD cord-005453-4057qib7 15802 19 ( ( -LRB- cord-005453-4057qib7 15802 20 ±136.0 ±136.0 NN cord-005453-4057qib7 15802 21 ) ) -RRB- cord-005453-4057qib7 15802 22 TNC TNC NNP cord-005453-4057qib7 15802 23 while while IN cord-005453-4057qib7 15802 24 ECC ECC NNP cord-005453-4057qib7 15802 25 were be VBD cord-005453-4057qib7 15802 26 asked ask VBN cord-005453-4057qib7 15802 27 for for IN cord-005453-4057qib7 15802 28 184.7 184.7 CD cord-005453-4057qib7 15802 29 * * NFP cord-005453-4057qib7 15802 30 10 10 CD cord-005453-4057qib7 15802 31 8 8 CD cord-005453-4057qib7 15802 32 ( ( -LRB- cord-005453-4057qib7 15802 33 ±105.7 ±105.7 RB cord-005453-4057qib7 15802 34 ) ) -RRB- cord-005453-4057qib7 15802 35 . . . cord-005453-4057qib7 15803 1 We -PRON- PRP cord-005453-4057qib7 15803 2 collected collect VBD cord-005453-4057qib7 15803 3 169.7 169.7 CD cord-005453-4057qib7 15803 4 * * SYM cord-005453-4057qib7 15803 5 10 10 CD cord-005453-4057qib7 15803 6 8 8 CD cord-005453-4057qib7 15803 7 ( ( -LRB- cord-005453-4057qib7 15803 8 ±82.3 ±82.3 NNP cord-005453-4057qib7 15803 9 ) ) -RRB- cord-005453-4057qib7 15803 10 and and CC cord-005453-4057qib7 15803 11 received receive VBD cord-005453-4057qib7 15803 12 204.5 204.5 CD cord-005453-4057qib7 15803 13 * * NFP cord-005453-4057qib7 15803 14 10 10 CD cord-005453-4057qib7 15803 15 8 8 CD cord-005453-4057qib7 15803 16 ( ( -LRB- cord-005453-4057qib7 15803 17 ±109.2 ±109.2 NNP cord-005453-4057qib7 15803 18 ) ) -RRB- cord-005453-4057qib7 15803 19 TNC TNC NNP cord-005453-4057qib7 15803 20 . . . cord-005453-4057qib7 15804 1 Correlation correlation NN cord-005453-4057qib7 15804 2 between between IN cord-005453-4057qib7 15804 3 requested request VBN cord-005453-4057qib7 15804 4 and and CC cord-005453-4057qib7 15804 5 collected collect VBD cord-005453-4057qib7 15804 6 TNC TNC NNP cord-005453-4057qib7 15804 7 was be VBD cord-005453-4057qib7 15804 8 0.69 0.69 CD cord-005453-4057qib7 15804 9 at at IN cord-005453-4057qib7 15804 10 ICC ICC NNP cord-005453-4057qib7 15804 11 and and CC cord-005453-4057qib7 15804 12 0.56 0.56 CD cord-005453-4057qib7 15804 13 for for IN cord-005453-4057qib7 15804 14 ECC.We ECC.We NNP cord-005453-4057qib7 15804 15 had have VBD cord-005453-4057qib7 15804 16 41.2 41.2 CD cord-005453-4057qib7 15804 17 % % NN cord-005453-4057qib7 15804 18 SC SC NNP cord-005453-4057qib7 15804 19 and and CC cord-005453-4057qib7 15804 20 26.8 26.8 CD cord-005453-4057qib7 15804 21 % % NN cord-005453-4057qib7 15804 22 OC oc NN cord-005453-4057qib7 15804 23 meaning mean VBG cord-005453-4057qib7 15804 24 an an DT cord-005453-4057qib7 15804 25 accomplishment accomplishment NN cord-005453-4057qib7 15804 26 of of IN cord-005453-4057qib7 15804 27 68.0 68.0 CD cord-005453-4057qib7 15804 28 % % NN cord-005453-4057qib7 15804 29 . . . cord-005453-4057qib7 15805 1 We -PRON- PRP cord-005453-4057qib7 15805 2 failed fail VBD cord-005453-4057qib7 15805 3 to to TO cord-005453-4057qib7 15805 4 collect collect VB cord-005453-4057qib7 15805 5 required require VBN cord-005453-4057qib7 15805 6 TNC TNC NNP cord-005453-4057qib7 15805 7 in in IN cord-005453-4057qib7 15805 8 32.0 32.0 CD cord-005453-4057qib7 15805 9 % % NN cord-005453-4057qib7 15805 10 . . . cord-005453-4057qib7 15806 1 Although although IN cord-005453-4057qib7 15806 2 85 85 CD cord-005453-4057qib7 15806 3 % % NN cord-005453-4057qib7 15806 4 of of IN cord-005453-4057qib7 15806 5 received receive VBN cord-005453-4057qib7 15806 6 BM BM NNP cord-005453-4057qib7 15806 7 fulfil fulfil VB cord-005453-4057qib7 15806 8 TNC TNC NNP cord-005453-4057qib7 15806 9 requirements requirement NNS cord-005453-4057qib7 15806 10 , , , cord-005453-4057qib7 15806 11 BM BM NNP cord-005453-4057qib7 15806 12 processing processing NN cord-005453-4057qib7 15806 13 lowered lower VBD cord-005453-4057qib7 15806 14 this this DT cord-005453-4057qib7 15806 15 value value NN cord-005453-4057qib7 15806 16 to to IN cord-005453-4057qib7 15806 17 55 55 CD cord-005453-4057qib7 15806 18 % % NN cord-005453-4057qib7 15806 19 due due JJ cord-005453-4057qib7 15806 20 to to IN cord-005453-4057qib7 15806 21 erythrocyte erythrocyte NN cord-005453-4057qib7 15806 22 removal removal NN cord-005453-4057qib7 15806 23 ( ( -LRB- cord-005453-4057qib7 15806 24 seven seven CD cord-005453-4057qib7 15806 25 patients patient NNS cord-005453-4057qib7 15806 26 with with IN cord-005453-4057qib7 15806 27 major major JJ cord-005453-4057qib7 15806 28 ABO ABO NNP cord-005453-4057qib7 15806 29 incompatibility incompatibility NN cord-005453-4057qib7 15806 30 ) ) -RRB- cord-005453-4057qib7 15806 31 and and CC cord-005453-4057qib7 15806 32 plasma plasma NN cord-005453-4057qib7 15806 33 reduction reduction NN cord-005453-4057qib7 15806 34 ( ( -LRB- cord-005453-4057qib7 15806 35 two two CD cord-005453-4057qib7 15806 36 patients patient NNS cord-005453-4057qib7 15806 37 with with IN cord-005453-4057qib7 15806 38 ABO ABO NNP cord-005453-4057qib7 15806 39 minor minor JJ cord-005453-4057qib7 15806 40 incompatibility incompatibility NN cord-005453-4057qib7 15806 41 ) ) -RRB- cord-005453-4057qib7 15806 42 . . . cord-005453-4057qib7 15807 1 These these DT cord-005453-4057qib7 15807 2 steps step NNS cord-005453-4057qib7 15807 3 reduce reduce VBP cord-005453-4057qib7 15807 4 final final JJ cord-005453-4057qib7 15807 5 TNC TNC NNP cord-005453-4057qib7 15807 6 available available JJ cord-005453-4057qib7 15807 7 for for IN cord-005453-4057qib7 15807 8 transplant transplant NN cord-005453-4057qib7 15807 9 . . . cord-005453-4057qib7 15808 1 Weight weight NN cord-005453-4057qib7 15808 2 difference difference NN cord-005453-4057qib7 15808 3 between between IN cord-005453-4057qib7 15808 4 donor donor NN cord-005453-4057qib7 15808 5 and and CC cord-005453-4057qib7 15808 6 patient patient NN cord-005453-4057qib7 15808 7 had have VBD cord-005453-4057qib7 15808 8 no no DT cord-005453-4057qib7 15808 9 significant significant JJ cord-005453-4057qib7 15808 10 impact impact NN cord-005453-4057qib7 15808 11 on on IN cord-005453-4057qib7 15808 12 final final JJ cord-005453-4057qib7 15808 13 TNC TNC NNP cord-005453-4057qib7 15808 14 collection collection NN cord-005453-4057qib7 15808 15 performance performance NN cord-005453-4057qib7 15808 16 . . . cord-005453-4057qib7 15809 1 Sixteen sixteen CD cord-005453-4057qib7 15809 2 BM BM NNP cord-005453-4057qib7 15809 3 from from IN cord-005453-4057qib7 15809 4 ICC ICC NNP cord-005453-4057qib7 15809 5 ( ( -LRB- cord-005453-4057qib7 15809 6 seven seven CD cord-005453-4057qib7 15809 7 Staphylococcus Staphylococcus NNP cord-005453-4057qib7 15809 8 spp spp NNS cord-005453-4057qib7 15809 9 . . . cord-005453-4057qib7 15810 1 , , , cord-005453-4057qib7 15810 2 five five CD cord-005453-4057qib7 15810 3 Propionibacterium Propionibacterium NNP cord-005453-4057qib7 15810 4 acnesand acnesand NN cord-005453-4057qib7 15810 5 fourCorynebacterium fourcorynebacterium NN cord-005453-4057qib7 15810 6 spp spp NN cord-005453-4057qib7 15810 7 . . . cord-005453-4057qib7 15810 8 ) ) -RRB- cord-005453-4057qib7 15811 1 Background background NN cord-005453-4057qib7 15811 2 : : : cord-005453-4057qib7 15812 1 Success success NN cord-005453-4057qib7 15812 2 of of IN cord-005453-4057qib7 15812 3 peripheral peripheral JJ cord-005453-4057qib7 15812 4 blood blood NN cord-005453-4057qib7 15812 5 stem stem NN cord-005453-4057qib7 15812 6 cell cell NN cord-005453-4057qib7 15812 7 ( ( -LRB- cord-005453-4057qib7 15812 8 PBSC PBSC NNP cord-005453-4057qib7 15812 9 ) ) -RRB- cord-005453-4057qib7 15812 10 collections collection NNS cord-005453-4057qib7 15812 11 depends depend VBZ cord-005453-4057qib7 15812 12 on on IN cord-005453-4057qib7 15812 13 patient patient JJ cord-005453-4057qib7 15812 14 biological biological JJ cord-005453-4057qib7 15812 15 parameters parameter NNS cord-005453-4057qib7 15812 16 and and CC cord-005453-4057qib7 15812 17 stable stable JJ cord-005453-4057qib7 15812 18 apheresis apheresis NN cord-005453-4057qib7 15812 19 device device NN cord-005453-4057qib7 15812 20 performance performance NN cord-005453-4057qib7 15812 21 . . . cord-005453-4057qib7 15813 1 Peripheral peripheral JJ cord-005453-4057qib7 15813 2 blood blood NN cord-005453-4057qib7 15814 1 CD34 CD34 NNP cord-005453-4057qib7 15814 2 + + CC cord-005453-4057qib7 15814 3 cell cell NN cord-005453-4057qib7 15814 4 enumeration enumeration NN cord-005453-4057qib7 15814 5 is be VBZ cord-005453-4057qib7 15814 6 the the DT cord-005453-4057qib7 15814 7 most most RBS cord-005453-4057qib7 15814 8 reliable reliable JJ cord-005453-4057qib7 15814 9 predictive predictive JJ cord-005453-4057qib7 15814 10 factor factor NN cord-005453-4057qib7 15814 11 of of IN cord-005453-4057qib7 15814 12 apheresis apheresis NN cord-005453-4057qib7 15814 13 yield yield NN cord-005453-4057qib7 15814 14 however however RB cord-005453-4057qib7 15814 15 , , , cord-005453-4057qib7 15814 16 there there EX cord-005453-4057qib7 15814 17 are be VBP cord-005453-4057qib7 15814 18 some some DT cord-005453-4057qib7 15814 19 unexpectedly unexpectedly RB cord-005453-4057qib7 15814 20 poor poor JJ cord-005453-4057qib7 15814 21 CD34 CD34 NNP cord-005453-4057qib7 15814 22 + + CC cord-005453-4057qib7 15814 23 cell cell NN cord-005453-4057qib7 15814 24 harvests harvest NNS cord-005453-4057qib7 15814 25 despite despite IN cord-005453-4057qib7 15814 26 successful successful JJ cord-005453-4057qib7 15814 27 mobilization mobilization NN cord-005453-4057qib7 15814 28 . . . cord-005453-4057qib7 15815 1 The the DT cord-005453-4057qib7 15815 2 aim aim NN cord-005453-4057qib7 15815 3 of of IN cord-005453-4057qib7 15815 4 the the DT cord-005453-4057qib7 15815 5 study study NN cord-005453-4057qib7 15815 6 was be VBD cord-005453-4057qib7 15815 7 assess assess VB cord-005453-4057qib7 15815 8 total total JJ cord-005453-4057qib7 15815 9 collections collection NNS cord-005453-4057qib7 15816 1 CD34 CD34 NNP cord-005453-4057qib7 15816 2 + + CC cord-005453-4057qib7 15816 3 yields yield NNS cord-005453-4057qib7 15816 4 and and CC cord-005453-4057qib7 15816 5 factors factor NNS cord-005453-4057qib7 15816 6 influencing influence VBG cord-005453-4057qib7 15816 7 main main JJ cord-005453-4057qib7 15816 8 apheresis apheresis NN cord-005453-4057qib7 15816 9 procedure procedure NN cord-005453-4057qib7 15816 10 outcomes outcome NNS cord-005453-4057qib7 15816 11 including include VBG cord-005453-4057qib7 15816 12 collection collection NN cord-005453-4057qib7 15816 13 efficiency efficiency NN cord-005453-4057qib7 15816 14 ( ( -LRB- cord-005453-4057qib7 15816 15 CE).Methods ce).method NNS cord-005453-4057qib7 15816 16 : : : cord-005453-4057qib7 15816 17 Of of IN cord-005453-4057qib7 15816 18 2233 2233 CD cord-005453-4057qib7 15816 19 consecutive consecutive JJ cord-005453-4057qib7 15816 20 donors donor NNS cord-005453-4057qib7 15816 21 covering cover VBG cord-005453-4057qib7 15816 22 the the DT cord-005453-4057qib7 15816 23 period period NN cord-005453-4057qib7 15816 24 1 1 CD cord-005453-4057qib7 15816 25 - - HYPH cord-005453-4057qib7 15816 26 1 1 CD cord-005453-4057qib7 15816 27 - - HYPH cord-005453-4057qib7 15816 28 2016 2016 CD cord-005453-4057qib7 15816 29 to to TO cord-005453-4057qib7 15816 30 30 30 CD cord-005453-4057qib7 15816 31 - - SYM cord-005453-4057qib7 15816 32 9 9 CD cord-005453-4057qib7 15816 33 - - SYM cord-005453-4057qib7 15816 34 2018 2018 CD cord-005453-4057qib7 15816 35 were be VBD cord-005453-4057qib7 15816 36 analyzed analyze VBN cord-005453-4057qib7 15816 37 for for IN cord-005453-4057qib7 15816 38 the the DT cord-005453-4057qib7 15816 39 following follow VBG cord-005453-4057qib7 15816 40 parameters parameter NNS cord-005453-4057qib7 15816 41 : : : cord-005453-4057qib7 15816 42 pre pre VB cord-005453-4057qib7 15816 43 CD34 CD34 NNP cord-005453-4057qib7 15816 44 count count VB cord-005453-4057qib7 15817 1 , , , cord-005453-4057qib7 15817 2 CD34 CD34 NNP cord-005453-4057qib7 15817 3 yield yield NN cord-005453-4057qib7 15817 4 per per IN cord-005453-4057qib7 15817 5 procedure procedure NN cord-005453-4057qib7 15817 6 , , , cord-005453-4057qib7 15817 7 total total JJ cord-005453-4057qib7 15817 8 CD34 CD34 NNP cord-005453-4057qib7 15817 9 dose dose NN cord-005453-4057qib7 15817 10 collected collect VBN cord-005453-4057qib7 15817 11 per per IN cord-005453-4057qib7 15817 12 patient patient NN cord-005453-4057qib7 15817 13 , , , cord-005453-4057qib7 15817 14 CD34 CD34 NNP cord-005453-4057qib7 15817 15 collection collection NN cord-005453-4057qib7 15817 16 targets target NNS cord-005453-4057qib7 15817 17 requested request VBN cord-005453-4057qib7 15817 18 by by IN cord-005453-4057qib7 15817 19 clinical clinical JJ cord-005453-4057qib7 15817 20 teams team NNS cord-005453-4057qib7 15817 21 . . . cord-005453-4057qib7 15818 1 The the DT cord-005453-4057qib7 15818 2 efficiency efficiency NN cord-005453-4057qib7 15818 3 of of IN cord-005453-4057qib7 15818 4 PBSC PBSC NNP cord-005453-4057qib7 15818 5 procedures procedure NNS cord-005453-4057qib7 15818 6 was be VBD cord-005453-4057qib7 15818 7 determined determine VBN cord-005453-4057qib7 15818 8 by by IN cord-005453-4057qib7 15818 9 calculating calculate VBG cord-005453-4057qib7 15818 10 the the DT cord-005453-4057qib7 15818 11 CE CE NNP cord-005453-4057qib7 15818 12 and and CC cord-005453-4057qib7 15818 13 the the DT cord-005453-4057qib7 15818 14 correlation correlation NN cord-005453-4057qib7 15818 15 coefficient coefficient NN cord-005453-4057qib7 15818 16 between between IN cord-005453-4057qib7 15818 17 pre pre `` cord-005453-4057qib7 15818 18 CD34 CD34 NNP cord-005453-4057qib7 15818 19 count count VB cord-005453-4057qib7 15818 20 and and CC cord-005453-4057qib7 15818 21 yield yield VB cord-005453-4057qib7 15818 22 per per IN cord-005453-4057qib7 15818 23 procedure procedure NN cord-005453-4057qib7 15818 24 . . . cord-005453-4057qib7 15819 1 CE CE NNP cord-005453-4057qib7 15819 2 was be VBD cord-005453-4057qib7 15819 3 correlated correlate VBN cord-005453-4057qib7 15819 4 to to TO cord-005453-4057qib7 15819 5 preprocedure preprocedure VB cord-005453-4057qib7 15819 6 WBC WBC NNP cord-005453-4057qib7 15819 7 , , , cord-005453-4057qib7 15819 8 platelet platelet NN cord-005453-4057qib7 15819 9 count count NN cord-005453-4057qib7 15819 10 , , , cord-005453-4057qib7 15819 11 pre pre VB cord-005453-4057qib7 15819 12 CD34 CD34 NNP cord-005453-4057qib7 15819 13 count count NN cord-005453-4057qib7 15819 14 and and CC cord-005453-4057qib7 15819 15 blood blood NN cord-005453-4057qib7 15819 16 volume volume NN cord-005453-4057qib7 15819 17 processed process VBN cord-005453-4057qib7 15819 18 . . . cord-005453-4057qib7 15820 1 All all DT cord-005453-4057qib7 15820 2 PBSC PBSC NNP cord-005453-4057qib7 15820 3 collections collection NNS cord-005453-4057qib7 15820 4 were be VBD cord-005453-4057qib7 15820 5 performed perform VBN cord-005453-4057qib7 15820 6 by by IN cord-005453-4057qib7 15820 7 Optia Optia NNP cord-005453-4057qib7 15820 8 Spectra Spectra NNP cord-005453-4057qib7 15820 9 across across IN cord-005453-4057qib7 15820 10 7 7 CD cord-005453-4057qib7 15820 11 units unit NNS cord-005453-4057qib7 15820 12 in in IN cord-005453-4057qib7 15820 13 UK.Results uk.results CD cord-005453-4057qib7 15820 14 : : : cord-005453-4057qib7 15821 1 Of of IN cord-005453-4057qib7 15821 2 the the DT cord-005453-4057qib7 15821 3 2233 2233 CD cord-005453-4057qib7 15821 4 donors donor NNS cord-005453-4057qib7 15821 5 , , , cord-005453-4057qib7 15821 6 1611 1611 CD cord-005453-4057qib7 15821 7 were be VBD cord-005453-4057qib7 15821 8 autologous autologous JJ cord-005453-4057qib7 15821 9 and and CC cord-005453-4057qib7 15821 10 622 622 CD cord-005453-4057qib7 15821 11 allogeneic allogeneic NN cord-005453-4057qib7 15821 12 . . . cord-005453-4057qib7 15822 1 The the DT cord-005453-4057qib7 15822 2 autologous autologous JJ cord-005453-4057qib7 15822 3 donors donor NNS cord-005453-4057qib7 15822 4 underwent undergo VBD cord-005453-4057qib7 15822 5 in in IN cord-005453-4057qib7 15822 6 total total JJ cord-005453-4057qib7 15822 7 2543 2543 CD cord-005453-4057qib7 15822 8 procedures procedure NNS cord-005453-4057qib7 15822 9 . . . cord-005453-4057qib7 15823 1 The the DT cord-005453-4057qib7 15823 2 median median JJ cord-005453-4057qib7 15823 3 CD34 CD34 NNP cord-005453-4057qib7 15823 4 target target NN cord-005453-4057qib7 15823 5 dose dose NN cord-005453-4057qib7 15823 6 for for IN cord-005453-4057qib7 15823 7 these these DT cord-005453-4057qib7 15823 8 donors donor NNS cord-005453-4057qib7 15823 9 was be VBD cord-005453-4057qib7 15823 10 4x10 4x10 CD cord-005453-4057qib7 15823 11 6 6 CD cord-005453-4057qib7 15823 12 /kg.799 /kg.799 . cord-005453-4057qib7 15823 13 ( ( -LRB- cord-005453-4057qib7 15823 14 50 50 CD cord-005453-4057qib7 15823 15 % % NN cord-005453-4057qib7 15823 16 ) ) -RRB- cord-005453-4057qib7 15823 17 achieved achieve VBD cord-005453-4057qib7 15823 18 the the DT cord-005453-4057qib7 15823 19 target target NN cord-005453-4057qib7 15823 20 dose dose NN cord-005453-4057qib7 15823 21 with with IN cord-005453-4057qib7 15823 22 1 1 CD cord-005453-4057qib7 15823 23 procedure procedure NN cord-005453-4057qib7 15823 24 and and CC cord-005453-4057qib7 15823 25 566 566 CD cord-005453-4057qib7 15823 26 ( ( -LRB- cord-005453-4057qib7 15823 27 35 35 CD cord-005453-4057qib7 15823 28 % % NN cord-005453-4057qib7 15823 29 ) ) -RRB- cord-005453-4057qib7 15823 30 with with IN cord-005453-4057qib7 15823 31 2 2 CD cord-005453-4057qib7 15823 32 procedures procedure NNS cord-005453-4057qib7 15823 33 . . . cord-005453-4057qib7 15824 1 The the DT cord-005453-4057qib7 15824 2 median median NN cord-005453-4057qib7 15824 3 pre pre JJ cord-005453-4057qib7 15824 4 CD34 CD34 NNP cord-005453-4057qib7 15824 5 count count NN cord-005453-4057qib7 15824 6 was be VBD cord-005453-4057qib7 15824 7 30 30 CD cord-005453-4057qib7 15824 8 / / SYM cord-005453-4057qib7 15824 9 μl μl NN cord-005453-4057qib7 15824 10 . . . cord-005453-4057qib7 15825 1 The the DT cord-005453-4057qib7 15825 2 median median JJ cord-005453-4057qib7 15825 3 CD34 CD34 NNP cord-005453-4057qib7 15825 4 yield yield NN cord-005453-4057qib7 15825 5 per per IN cord-005453-4057qib7 15825 6 procedure procedure NN cord-005453-4057qib7 15825 7 was be VBD cord-005453-4057qib7 15825 8 2.54x10 2.54x10 CD cord-005453-4057qib7 15825 9 6 6 CD cord-005453-4057qib7 15825 10 /kg /kg . cord-005453-4057qib7 15825 11 and and CC cord-005453-4057qib7 15825 12 the the DT cord-005453-4057qib7 15825 13 median median JJ cord-005453-4057qib7 15825 14 total total JJ cord-005453-4057qib7 15825 15 CD34 CD34 NNP cord-005453-4057qib7 15825 16 dose dose NN cord-005453-4057qib7 15825 17 collected collect VBN cord-005453-4057qib7 15825 18 per per IN cord-005453-4057qib7 15825 19 donor donor NN cord-005453-4057qib7 15825 20 was be VBD cord-005453-4057qib7 15825 21 5.38x10 5.38x10 CD cord-005453-4057qib7 15825 22 6 6 CD cord-005453-4057qib7 15826 1 /kg /kg NFP cord-005453-4057qib7 15826 2 . . . cord-005453-4057qib7 15826 3 92 92 CD cord-005453-4057qib7 15826 4 ( ( -LRB- cord-005453-4057qib7 15826 5 5.7 5.7 CD cord-005453-4057qib7 15826 6 % % NN cord-005453-4057qib7 15826 7 ) ) -RRB- cord-005453-4057qib7 15826 8 of of IN cord-005453-4057qib7 15826 9 autologous autologous JJ cord-005453-4057qib7 15826 10 donors donor NNS cord-005453-4057qib7 15826 11 collected collect VBD cord-005453-4057qib7 15826 12 a a DT cord-005453-4057qib7 15826 13 total total JJ cord-005453-4057qib7 15826 14 CD34 CD34 NNP cord-005453-4057qib7 15826 15 dose dose NN cord-005453-4057qib7 15826 16 < < NNP cord-005453-4057qib7 15826 17 2x10 2x10 CD cord-005453-4057qib7 15826 18 6 6 CD cord-005453-4057qib7 15826 19 /kg /kg NFP cord-005453-4057qib7 15826 20 , , , cord-005453-4057qib7 15826 21 of of IN cord-005453-4057qib7 15826 22 those those DT cord-005453-4057qib7 15826 23 27 27 CD cord-005453-4057qib7 15826 24 ( ( -LRB- cord-005453-4057qib7 15826 25 1.7 1.7 CD cord-005453-4057qib7 15826 26 % % NN cord-005453-4057qib7 15826 27 ) ) -RRB- cord-005453-4057qib7 15826 28 had have VBD cord-005453-4057qib7 15826 29 a a DT cord-005453-4057qib7 15826 30 pre pre JJ cord-005453-4057qib7 15826 31 CD34 CD34 NNP cord-005453-4057qib7 15826 32 count count VB cord-005453-4057qib7 15827 1 < < NNP cord-005453-4057qib7 15827 2 10 10 CD cord-005453-4057qib7 15827 3 / / SYM cord-005453-4057qib7 15827 4 μl μl NN cord-005453-4057qib7 15827 5 and and CC cord-005453-4057qib7 15827 6 65 65 CD cord-005453-4057qib7 15827 7 ( ( -LRB- cord-005453-4057qib7 15827 8 4 4 CD cord-005453-4057qib7 15827 9 % % NN cord-005453-4057qib7 15827 10 ) ) -RRB- cord-005453-4057qib7 15828 1 > > XX cord-005453-4057qib7 15829 1 10 10 CD cord-005453-4057qib7 15829 2 / / SYM cord-005453-4057qib7 15829 3 μl μl NN cord-005453-4057qib7 15829 4 . . . cord-005453-4057qib7 15830 1 The the DT cord-005453-4057qib7 15830 2 allogeneic allogeneic NN cord-005453-4057qib7 15830 3 donors donor NNS cord-005453-4057qib7 15830 4 underwent undergo VBD cord-005453-4057qib7 15830 5 in in IN cord-005453-4057qib7 15830 6 total total JJ cord-005453-4057qib7 15830 7 878 878 CD cord-005453-4057qib7 15830 8 procedures procedure NNS cord-005453-4057qib7 15830 9 . . . cord-005453-4057qib7 15831 1 The the DT cord-005453-4057qib7 15831 2 median median JJ cord-005453-4057qib7 15831 3 CD34 CD34 NNP cord-005453-4057qib7 15831 4 target target NN cord-005453-4057qib7 15831 5 dose dose NN cord-005453-4057qib7 15831 6 for for IN cord-005453-4057qib7 15831 7 these these DT cord-005453-4057qib7 15831 8 donors donor NNS cord-005453-4057qib7 15831 9 was be VBD cord-005453-4057qib7 15831 10 5x10 5x10 CD cord-005453-4057qib7 15831 11 6 6 CD cord-005453-4057qib7 15831 12 / / SYM cord-005453-4057qib7 15831 13 kg kg NNS cord-005453-4057qib7 15831 14 . . . cord-005453-4057qib7 15832 1 381 381 CD cord-005453-4057qib7 15832 2 allogeneic allogeneic IN cord-005453-4057qib7 15832 3 donors donor NNS cord-005453-4057qib7 15832 4 ( ( -LRB- cord-005453-4057qib7 15832 5 61 61 CD cord-005453-4057qib7 15832 6 % % NN cord-005453-4057qib7 15832 7 ) ) -RRB- cord-005453-4057qib7 15832 8 achieved achieve VBD cord-005453-4057qib7 15832 9 the the DT cord-005453-4057qib7 15832 10 target target NN cord-005453-4057qib7 15832 11 dose dose NN cord-005453-4057qib7 15832 12 with with IN cord-005453-4057qib7 15832 13 1 1 CD cord-005453-4057qib7 15832 14 procedure procedure NN cord-005453-4057qib7 15832 15 and and CC cord-005453-4057qib7 15832 16 221 221 CD cord-005453-4057qib7 15832 17 ( ( -LRB- cord-005453-4057qib7 15832 18 36 36 CD cord-005453-4057qib7 15832 19 % % NN cord-005453-4057qib7 15832 20 ) ) -RRB- cord-005453-4057qib7 15832 21 with with IN cord-005453-4057qib7 15832 22 2 2 CD cord-005453-4057qib7 15832 23 procedures procedure NNS cord-005453-4057qib7 15832 24 . . . cord-005453-4057qib7 15833 1 The the DT cord-005453-4057qib7 15833 2 median median NN cord-005453-4057qib7 15833 3 pre pre JJ cord-005453-4057qib7 15833 4 CD34 CD34 NNP cord-005453-4057qib7 15833 5 count count NN cord-005453-4057qib7 15833 6 was be VBD cord-005453-4057qib7 15833 7 51 51 CD cord-005453-4057qib7 15833 8 / / SYM cord-005453-4057qib7 15833 9 μl μl NN cord-005453-4057qib7 15833 10 . . . cord-005453-4057qib7 15834 1 The the DT cord-005453-4057qib7 15834 2 median median JJ cord-005453-4057qib7 15834 3 CD34 CD34 NNP cord-005453-4057qib7 15834 4 yield yield NN cord-005453-4057qib7 15834 5 per per IN cord-005453-4057qib7 15834 6 procedure procedure NN cord-005453-4057qib7 15834 7 was be VBD cord-005453-4057qib7 15834 8 4.07x10 4.07x10 CD cord-005453-4057qib7 15834 9 6 6 CD cord-005453-4057qib7 15834 10 /kg /kg . cord-005453-4057qib7 15834 11 and and CC cord-005453-4057qib7 15834 12 the the DT cord-005453-4057qib7 15834 13 median median NN cord-005453-4057qib7 15834 14 of of IN cord-005453-4057qib7 15834 15 total total JJ cord-005453-4057qib7 15834 16 CD34 CD34 NNP cord-005453-4057qib7 15834 17 dose dose NN cord-005453-4057qib7 15834 18 collected collect VBN cord-005453-4057qib7 15834 19 per per IN cord-005453-4057qib7 15834 20 donor donor NN cord-005453-4057qib7 15834 21 was be VBD cord-005453-4057qib7 15834 22 6.70x10 6.70x10 CD cord-005453-4057qib7 15834 23 6 6 CD cord-005453-4057qib7 15835 1 /kg /kg NFP cord-005453-4057qib7 15835 2 . . . cord-005453-4057qib7 15836 1 17 17 CD cord-005453-4057qib7 15836 2 ( ( -LRB- cord-005453-4057qib7 15836 3 2.7 2.7 CD cord-005453-4057qib7 15836 4 ) ) -RRB- cord-005453-4057qib7 15836 5 % % NN cord-005453-4057qib7 15836 6 of of IN cord-005453-4057qib7 15836 7 allogeneic allogeneic NN cord-005453-4057qib7 15836 8 donors donor NNS cord-005453-4057qib7 15836 9 collected collect VBD cord-005453-4057qib7 15836 10 a a DT cord-005453-4057qib7 15836 11 total total JJ cord-005453-4057qib7 15836 12 CD34 CD34 NNP cord-005453-4057qib7 15836 13 dose dose NN cord-005453-4057qib7 15836 14 < < NNP cord-005453-4057qib7 15836 15 2x10 2x10 CD cord-005453-4057qib7 15836 16 6 6 CD cord-005453-4057qib7 15836 17 / / SYM cord-005453-4057qib7 15836 18 kg kg NNS cord-005453-4057qib7 15836 19 , , , cord-005453-4057qib7 15836 20 of of IN cord-005453-4057qib7 15836 21 those those DT cord-005453-4057qib7 15836 22 3 3 CD cord-005453-4057qib7 15836 23 ( ( -LRB- cord-005453-4057qib7 15836 24 0.5 0.5 CD cord-005453-4057qib7 15836 25 % % NN cord-005453-4057qib7 15836 26 ) ) -RRB- cord-005453-4057qib7 15836 27 had have VBD cord-005453-4057qib7 15836 28 a a DT cord-005453-4057qib7 15836 29 pre pre JJ cord-005453-4057qib7 15836 30 CD34 CD34 NNP cord-005453-4057qib7 15836 31 count count VB cord-005453-4057qib7 15837 1 < < NNP cord-005453-4057qib7 15837 2 10 10 CD cord-005453-4057qib7 15837 3 / / SYM cord-005453-4057qib7 15837 4 μl μl NN cord-005453-4057qib7 15837 5 and and CC cord-005453-4057qib7 15837 6 14 14 CD cord-005453-4057qib7 15837 7 ( ( -LRB- cord-005453-4057qib7 15837 8 2.2 2.2 CD cord-005453-4057qib7 15837 9 % % NN cord-005453-4057qib7 15837 10 ) ) -RRB- cord-005453-4057qib7 15838 1 > > XX cord-005453-4057qib7 15839 1 10 10 CD cord-005453-4057qib7 15839 2 / / SYM cord-005453-4057qib7 15839 3 μl μl NN cord-005453-4057qib7 15839 4 . . . cord-005453-4057qib7 15840 1 The the DT cord-005453-4057qib7 15840 2 median median NN cord-005453-4057qib7 15840 3 CE ce NN cord-005453-4057qib7 15840 4 for for IN cord-005453-4057qib7 15840 5 autologous autologous JJ cord-005453-4057qib7 15840 6 donors donor NNS cord-005453-4057qib7 15840 7 was be VBD cord-005453-4057qib7 15840 8 55 55 CD cord-005453-4057qib7 15840 9 % % NN cord-005453-4057qib7 15840 10 ( ( -LRB- cord-005453-4057qib7 15840 11 range range NN cord-005453-4057qib7 15840 12 20 20 CD cord-005453-4057qib7 15840 13 - - SYM cord-005453-4057qib7 15840 14 166 166 CD cord-005453-4057qib7 15840 15 ) ) -RRB- cord-005453-4057qib7 15840 16 and and CC cord-005453-4057qib7 15840 17 for for IN cord-005453-4057qib7 15840 18 allogeneic allogeneic NN cord-005453-4057qib7 15840 19 donors donor NNS cord-005453-4057qib7 15840 20 was be VBD cord-005453-4057qib7 15840 21 47 47 CD cord-005453-4057qib7 15840 22 % % NN cord-005453-4057qib7 15840 23 ( ( -LRB- cord-005453-4057qib7 15840 24 range12 range12 NNP cord-005453-4057qib7 15840 25 - - HYPH cord-005453-4057qib7 15840 26 116 116 CD cord-005453-4057qib7 15840 27 ) ) -RRB- cord-005453-4057qib7 15840 28 . . . cord-005453-4057qib7 15841 1 The the DT cord-005453-4057qib7 15841 2 CE CE NNP cord-005453-4057qib7 15841 3 was be VBD cord-005453-4057qib7 15841 4 negatively negatively RB cord-005453-4057qib7 15841 5 correlated correlate VBN cord-005453-4057qib7 15841 6 to to IN cord-005453-4057qib7 15841 7 WBC WBC NNP cord-005453-4057qib7 15841 8 ( ( -LRB- cord-005453-4057qib7 15841 9 r= r= NNP cord-005453-4057qib7 15841 10 -0.29 -0.29 HYPH cord-005453-4057qib7 15841 11 and and CC cord-005453-4057qib7 15841 12 -0.37 -0.37 CD cord-005453-4057qib7 15841 13 ) ) -RRB- cord-005453-4057qib7 15841 14 and and CC cord-005453-4057qib7 15841 15 platelet platelet NN cord-005453-4057qib7 15841 16 count count NN cord-005453-4057qib7 15841 17 ( ( -LRB- cord-005453-4057qib7 15841 18 r=-0.14 r=-0.14 JJ cord-005453-4057qib7 15841 19 and and CC cord-005453-4057qib7 15841 20 -0.06 -0.06 CD cord-005453-4057qib7 15841 21 ) ) -RRB- cord-005453-4057qib7 15841 22 for for IN cord-005453-4057qib7 15841 23 auto auto NN cord-005453-4057qib7 15841 24 and and CC cord-005453-4057qib7 15841 25 allogeneic allogeneic IN cord-005453-4057qib7 15841 26 donors donor NNS cord-005453-4057qib7 15841 27 respectively respectively RB cord-005453-4057qib7 15841 28 , , , cord-005453-4057qib7 15841 29 but but CC cord-005453-4057qib7 15841 30 did do VBD cord-005453-4057qib7 15841 31 not not RB cord-005453-4057qib7 15841 32 correlate correlate VB cord-005453-4057qib7 15841 33 to to IN cord-005453-4057qib7 15841 34 the the DT cord-005453-4057qib7 15841 35 pre pre JJ cord-005453-4057qib7 15841 36 CD34 CD34 NNP cord-005453-4057qib7 15841 37 and and CC cord-005453-4057qib7 15841 38 blood blood NN cord-005453-4057qib7 15841 39 volume volume NN cord-005453-4057qib7 15841 40 processed process VBN cord-005453-4057qib7 15841 41 . . . cord-005453-4057qib7 15842 1 The the DT cord-005453-4057qib7 15842 2 correlation correlation NN cord-005453-4057qib7 15842 3 coefficient coefficient NN cord-005453-4057qib7 15842 4 between between IN cord-005453-4057qib7 15842 5 pre pre `` cord-005453-4057qib7 15842 6 CD34 CD34 NNP cord-005453-4057qib7 15842 7 count count NN cord-005453-4057qib7 15842 8 and and CC cord-005453-4057qib7 15842 9 CD34 CD34 NNP cord-005453-4057qib7 15842 10 yield yield NN cord-005453-4057qib7 15842 11 per per IN cord-005453-4057qib7 15842 12 procedure procedure NN cord-005453-4057qib7 15842 13 was be VBD cord-005453-4057qib7 15842 14 r r NNP cord-005453-4057qib7 15842 15 2 2 CD cord-005453-4057qib7 15842 16 = = SYM cord-005453-4057qib7 15842 17 0.67 0.67 CD cord-005453-4057qib7 15842 18 for for IN cord-005453-4057qib7 15842 19 the the DT cord-005453-4057qib7 15842 20 autologous autologous JJ cord-005453-4057qib7 15842 21 and and CC cord-005453-4057qib7 15842 22 r r NN cord-005453-4057qib7 15842 23 2 2 CD cord-005453-4057qib7 15842 24 = = SYM cord-005453-4057qib7 15842 25 0.34 0.34 CD cord-005453-4057qib7 15842 26 for for IN cord-005453-4057qib7 15842 27 the the DT cord-005453-4057qib7 15842 28 allogeneic allogeneic NN cord-005453-4057qib7 15842 29 collections collection NNS cord-005453-4057qib7 15842 30 . . . cord-005453-4057qib7 15843 1 Conclusions conclusion NNS cord-005453-4057qib7 15843 2 : : : cord-005453-4057qib7 15844 1 The the DT cord-005453-4057qib7 15844 2 majority majority NN cord-005453-4057qib7 15844 3 of of IN cord-005453-4057qib7 15844 4 autologous autologous JJ cord-005453-4057qib7 15844 5 and and CC cord-005453-4057qib7 15844 6 allogeneic allogeneic IN cord-005453-4057qib7 15844 7 donors donor NNS cord-005453-4057qib7 15844 8 achieved achieve VBD cord-005453-4057qib7 15844 9 the the DT cord-005453-4057qib7 15844 10 target target NN cord-005453-4057qib7 15844 11 CD34 CD34 NNP cord-005453-4057qib7 15844 12 dose dose NN cord-005453-4057qib7 15844 13 with with IN cord-005453-4057qib7 15844 14 one one CD cord-005453-4057qib7 15844 15 procedure procedure NN cord-005453-4057qib7 15844 16 . . . cord-005453-4057qib7 15845 1 94.3 94.3 CD cord-005453-4057qib7 15845 2 % % NN cord-005453-4057qib7 15845 3 of of IN cord-005453-4057qib7 15845 4 autologous autologous JJ cord-005453-4057qib7 15845 5 and and CC cord-005453-4057qib7 15845 6 97.3 97.3 CD cord-005453-4057qib7 15845 7 % % NN cord-005453-4057qib7 15845 8 allogeneic allogeneic IN cord-005453-4057qib7 15845 9 donors donor NNS cord-005453-4057qib7 15845 10 collected collect VBD cord-005453-4057qib7 15845 11 a a DT cord-005453-4057qib7 15845 12 transplantable transplantable JJ cord-005453-4057qib7 15845 13 CD34 CD34 NNP cord-005453-4057qib7 15845 14 dose dose NN cord-005453-4057qib7 15845 15 of of IN cord-005453-4057qib7 15845 16 > > $ cord-005453-4057qib7 15845 17 2x10 2x10 CD cord-005453-4057qib7 15845 18 6 6 CD cord-005453-4057qib7 15846 1 /kg /kg NFP cord-005453-4057qib7 15846 2 . . . cord-005453-4057qib7 15847 1 4 4 CD cord-005453-4057qib7 15847 2 % % NN cord-005453-4057qib7 15847 3 of of IN cord-005453-4057qib7 15847 4 autologous autologous JJ cord-005453-4057qib7 15847 5 and and CC cord-005453-4057qib7 15847 6 2.7 2.7 CD cord-005453-4057qib7 15847 7 % % NN cord-005453-4057qib7 15847 8 of of IN cord-005453-4057qib7 15847 9 allogeneic allogeneic NN cord-005453-4057qib7 15847 10 donors donor NNS cord-005453-4057qib7 15847 11 did do VBD cord-005453-4057qib7 15847 12 not not RB cord-005453-4057qib7 15847 13 collect collect VB cord-005453-4057qib7 15847 14 a a DT cord-005453-4057qib7 15847 15 transplantable transplantable JJ cord-005453-4057qib7 15847 16 dose dose NN cord-005453-4057qib7 15847 17 despite despite IN cord-005453-4057qib7 15847 18 a a DT cord-005453-4057qib7 15847 19 preCD34 preCD34 NNP cord-005453-4057qib7 15847 20 count count NN cord-005453-4057qib7 15847 21 of of IN cord-005453-4057qib7 15847 22 > > XX cord-005453-4057qib7 15848 1 10 10 CD cord-005453-4057qib7 15848 2 / / SYM cord-005453-4057qib7 15848 3 μl μl IN cord-005453-4057qib7 15848 4 indicating indicate VBG cord-005453-4057qib7 15848 5 suboptimal suboptimal JJ cord-005453-4057qib7 15848 6 procedure procedure NN cord-005453-4057qib7 15848 7 performance performance NN cord-005453-4057qib7 15848 8 . . . cord-005453-4057qib7 15849 1 The the DT cord-005453-4057qib7 15849 2 CE CE NNP cord-005453-4057qib7 15849 3 was be VBD cord-005453-4057qib7 15849 4 variable variable JJ cord-005453-4057qib7 15849 5 and and CC cord-005453-4057qib7 15849 6 was be VBD cord-005453-4057qib7 15849 7 negatively negatively RB cord-005453-4057qib7 15849 8 correlated correlate VBN cord-005453-4057qib7 15849 9 to to IN cord-005453-4057qib7 15849 10 the the DT cord-005453-4057qib7 15849 11 preprocedure preprocedure NN cord-005453-4057qib7 15849 12 WBC WBC NNP cord-005453-4057qib7 15849 13 and and CC cord-005453-4057qib7 15849 14 platelet platelet NN cord-005453-4057qib7 15849 15 count count NN cord-005453-4057qib7 15849 16 . . . cord-005453-4057qib7 15850 1 The the DT cord-005453-4057qib7 15850 2 CE ce NN cord-005453-4057qib7 15850 3 and and CC cord-005453-4057qib7 15850 4 correlation correlation NN cord-005453-4057qib7 15850 5 coefficient coefficient NN cord-005453-4057qib7 15850 6 are be VBP cord-005453-4057qib7 15850 7 lower low JJR cord-005453-4057qib7 15850 8 in in IN cord-005453-4057qib7 15850 9 allogeneic allogeneic NN cord-005453-4057qib7 15850 10 donors donor NNS cord-005453-4057qib7 15850 11 compared compare VBN cord-005453-4057qib7 15850 12 to to IN cord-005453-4057qib7 15850 13 autologous autologous JJ cord-005453-4057qib7 15850 14 donors donor NNS cord-005453-4057qib7 15850 15 . . . cord-005453-4057qib7 15851 1 Disclosure disclosure NN cord-005453-4057qib7 15851 2 : : : cord-005453-4057qib7 15851 3 Nothing nothing NN cord-005453-4057qib7 15851 4 to to TO cord-005453-4057qib7 15851 5 declare declare VB cord-005453-4057qib7 15851 6 The the DT cord-005453-4057qib7 15851 7 outcome outcome NN cord-005453-4057qib7 15851 8 of of IN cord-005453-4057qib7 15851 9 autologous autologous JJ cord-005453-4057qib7 15851 10 blood blood NN cord-005453-4057qib7 15851 11 stem stem NN cord-005453-4057qib7 15851 12 cell cell NN cord-005453-4057qib7 15851 13 collection collection NN cord-005453-4057qib7 15851 14 and and CC cord-005453-4057qib7 15851 15 its -PRON- PRP$ cord-005453-4057qib7 15851 16 actual actual JJ cord-005453-4057qib7 15851 17 use use NN cord-005453-4057qib7 15851 18 in in IN cord-005453-4057qib7 15851 19 real real JJ cord-005453-4057qib7 15851 20 world world NN cord-005453-4057qib7 15851 21 : : : cord-005453-4057qib7 15851 22 the the DT cord-005453-4057qib7 15851 23 21st 21st JJ cord-005453-4057qib7 15851 24 century century NN cord-005453-4057qib7 15851 25 experienceKyoungmin experienceKyoungmin NNP cord-005453-4057qib7 15851 26 Lee Lee NNP cord-005453-4057qib7 15851 27 1 1 CD cord-005453-4057qib7 15851 28 , , , cord-005453-4057qib7 15851 29 Jung Jung NNP cord-005453-4057qib7 15851 30 Yong Yong NNP cord-005453-4057qib7 15851 31 Hong Hong NNP cord-005453-4057qib7 15851 32 1 1 CD cord-005453-4057qib7 15851 33 , , , cord-005453-4057qib7 15851 34 Dok Dok NNP cord-005453-4057qib7 15851 35 Hyun Hyun NNP cord-005453-4057qib7 15851 36 Yoon Yoon NNP cord-005453-4057qib7 15851 37 1 1 CD cord-005453-4057qib7 15851 38 , , , cord-005453-4057qib7 15851 39 Jae Jae NNP cord-005453-4057qib7 15851 40 - - HYPH cord-005453-4057qib7 15851 41 Lyun Lyun NNP cord-005453-4057qib7 15851 42 Lee Lee NNP cord-005453-4057qib7 15851 43 1 1 CD cord-005453-4057qib7 15851 44 , , , cord-005453-4057qib7 15851 45 Shin Shin NNP cord-005453-4057qib7 15851 46 Kim Kim NNP cord-005453-4057qib7 15851 47 1 1 CD cord-005453-4057qib7 15851 48 , , , cord-005453-4057qib7 15851 49 Kyoung Kyoung NNP cord-005453-4057qib7 15851 50 Min Min NNP cord-005453-4057qib7 15851 51 Lee Lee NNP cord-005453-4057qib7 15851 52 1 1 CD cord-005453-4057qib7 15851 53 , , , cord-005453-4057qib7 15851 54 Jung Jung NNP cord-005453-4057qib7 15851 55 Sun Sun NNP cord-005453-4057qib7 15851 56 Park Park NNP cord-005453-4057qib7 15851 57 1 1 CD cord-005453-4057qib7 15851 58 , , , cord-005453-4057qib7 15851 59 Cheolwon Cheolwon NNP cord-005453-4057qib7 15851 60 Suh Suh NNP cord-005453-4057qib7 15851 61 1Background 1background CD cord-005453-4057qib7 15852 1 : : : cord-005453-4057qib7 15852 2 Mobilized mobilize VBD cord-005453-4057qib7 15852 3 peripheral peripheral JJ cord-005453-4057qib7 15852 4 blood blood NN cord-005453-4057qib7 15852 5 stem stem NN cord-005453-4057qib7 15852 6 cells cell NNS cord-005453-4057qib7 15852 7 ( ( -LRB- cord-005453-4057qib7 15852 8 PBSCs pbsc NNS cord-005453-4057qib7 15852 9 ) ) -RRB- cord-005453-4057qib7 15852 10 have have VBP cord-005453-4057qib7 15852 11 largely largely RB cord-005453-4057qib7 15852 12 replaced replace VBN cord-005453-4057qib7 15852 13 bone bone NN cord-005453-4057qib7 15852 14 marrow marrow NN cord-005453-4057qib7 15852 15 as as IN cord-005453-4057qib7 15852 16 the the DT cord-005453-4057qib7 15852 17 graft graft NN cord-005453-4057qib7 15852 18 source source NN cord-005453-4057qib7 15852 19 for for IN cord-005453-4057qib7 15852 20 allogeneic allogeneic NN cord-005453-4057qib7 15852 21 stem stem NN cord-005453-4057qib7 15852 22 cell cell NN cord-005453-4057qib7 15852 23 transplantation transplantation NN cord-005453-4057qib7 15852 24 . . . cord-005453-4057qib7 15853 1 PBSCs pbsc NNS cord-005453-4057qib7 15853 2 mobilization mobilization NN cord-005453-4057qib7 15853 3 with with IN cord-005453-4057qib7 15853 4 G G NNP cord-005453-4057qib7 15853 5 - - HYPH cord-005453-4057qib7 15853 6 CSF CSF NNP cord-005453-4057qib7 15853 7 is be VBZ cord-005453-4057qib7 15853 8 highly highly RB cord-005453-4057qib7 15853 9 effective effective JJ cord-005453-4057qib7 15853 10 even even RB cord-005453-4057qib7 15853 11 on on IN cord-005453-4057qib7 15853 12 the the DT cord-005453-4057qib7 15853 13 4th 4th JJ cord-005453-4057qib7 15853 14 day day NN cord-005453-4057qib7 15853 15 in in IN cord-005453-4057qib7 15853 16 order order NN cord-005453-4057qib7 15853 17 to to TO cord-005453-4057qib7 15853 18 collect collect VB cord-005453-4057qib7 15853 19 enough enough JJ cord-005453-4057qib7 15853 20 number number NN cord-005453-4057qib7 15853 21 of of IN cord-005453-4057qib7 15853 22 stem stem NN cord-005453-4057qib7 15853 23 cells cell NNS cord-005453-4057qib7 15853 24 . . . cord-005453-4057qib7 15854 1 A a DT cord-005453-4057qib7 15854 2 longitudinal longitudinal JJ cord-005453-4057qib7 15854 3 , , , cord-005453-4057qib7 15854 4 prospective prospective JJ cord-005453-4057qib7 15854 5 , , , cord-005453-4057qib7 15854 6 observational observational JJ cord-005453-4057qib7 15854 7 , , , cord-005453-4057qib7 15854 8 single single JJ cord-005453-4057qib7 15854 9 - - HYPH cord-005453-4057qib7 15854 10 center center NN cord-005453-4057qib7 15854 11 , , , cord-005453-4057qib7 15854 12 cohort cohort NN cord-005453-4057qib7 15854 13 study study NN cord-005453-4057qib7 15854 14 on on IN cord-005453-4057qib7 15854 15 healthy healthy JJ cord-005453-4057qib7 15854 16 donors donor NNS cord-005453-4057qib7 15854 17 ( ( -LRB- cord-005453-4057qib7 15854 18 HDs HDs NNP cord-005453-4057qib7 15854 19 ) ) -RRB- cord-005453-4057qib7 15854 20 was be VBD cord-005453-4057qib7 15854 21 designed design VBN cord-005453-4057qib7 15854 22 to to TO cord-005453-4057qib7 15854 23 identify identify VB cord-005453-4057qib7 15854 24 predictors predictor NNS cord-005453-4057qib7 15854 25 of of IN cord-005453-4057qib7 15854 26 CD34 CD34 NNP cord-005453-4057qib7 15854 27 + + CC cord-005453-4057qib7 15854 28 cells cell NNS cord-005453-4057qib7 15854 29 on on IN cord-005453-4057qib7 15854 30 the the DT cord-005453-4057qib7 15854 31 4th 4th JJ cord-005453-4057qib7 15854 32 day day NN cord-005453-4057qib7 15854 33 . . . cord-005453-4057qib7 15855 1 Methods method NNS cord-005453-4057qib7 15855 2 : : : cord-005453-4057qib7 15856 1 As as IN cord-005453-4057qib7 15856 2 potential potential JJ cord-005453-4057qib7 15856 3 predictors predictor NNS cord-005453-4057qib7 15856 4 of of IN cord-005453-4057qib7 15856 5 mobilization mobilization NN cord-005453-4057qib7 15856 6 , , , cord-005453-4057qib7 15856 7 age age NN cord-005453-4057qib7 15856 8 , , , cord-005453-4057qib7 15856 9 sex sex NN cord-005453-4057qib7 15856 10 , , , cord-005453-4057qib7 15856 11 body body NN cord-005453-4057qib7 15856 12 weight weight NN cord-005453-4057qib7 15856 13 , , , cord-005453-4057qib7 15856 14 height height NN cord-005453-4057qib7 15856 15 , , , cord-005453-4057qib7 15856 16 blood blood NN cord-005453-4057qib7 15856 17 volume volume NN cord-005453-4057qib7 15856 18 as as RB cord-005453-4057qib7 15856 19 well well RB cord-005453-4057qib7 15856 20 as as IN cord-005453-4057qib7 15856 21 white white JJ cord-005453-4057qib7 15856 22 blood blood NN cord-005453-4057qib7 15856 23 cell cell NN cord-005453-4057qib7 15856 24 count count NN cord-005453-4057qib7 15856 25 , , , cord-005453-4057qib7 15856 26 peripheral peripheral JJ cord-005453-4057qib7 15856 27 blood blood NN cord-005453-4057qib7 15856 28 ( ( -LRB- cord-005453-4057qib7 15856 29 PB PB NNP cord-005453-4057qib7 15856 30 ) ) -RRB- cord-005453-4057qib7 15856 31 mononuclear mononuclear NN cord-005453-4057qib7 15856 32 cells cell NNS cord-005453-4057qib7 15856 33 , , , cord-005453-4057qib7 15856 34 platelet platelet NN cord-005453-4057qib7 15856 35 count count NN cord-005453-4057qib7 15856 36 , , , cord-005453-4057qib7 15856 37 hematocrit hematocrit NN cord-005453-4057qib7 15856 38 , , , cord-005453-4057qib7 15856 39 and and CC cord-005453-4057qib7 15856 40 hemoglobin hemoglobin NN cord-005453-4057qib7 15856 41 levels level NNS cord-005453-4057qib7 15856 42 were be VBD cord-005453-4057qib7 15856 43 considered consider VBN cord-005453-4057qib7 15856 44 . . . cord-005453-4057qib7 15857 1 Two two CD cord-005453-4057qib7 15857 2 different different JJ cord-005453-4057qib7 15857 3 evaluations evaluation NNS cord-005453-4057qib7 15857 4 of of IN cord-005453-4057qib7 15857 5 CD34 CD34 NNP cord-005453-4057qib7 15857 6 + + CC cord-005453-4057qib7 15857 7 cell cell NN cord-005453-4057qib7 15857 8 counts count NNS cord-005453-4057qib7 15857 9 were be VBD cord-005453-4057qib7 15857 10 determined determine VBN cord-005453-4057qib7 15857 11 for for IN cord-005453-4057qib7 15857 12 each each DT cord-005453-4057qib7 15857 13 donor donor NN cord-005453-4057qib7 15857 14 : : : cord-005453-4057qib7 15857 15 baseline baseline JJ cord-005453-4057qib7 15857 16 ( ( -LRB- cord-005453-4057qib7 15857 17 before before IN cord-005453-4057qib7 15857 18 granulocyte granulocyte NN cord-005453-4057qib7 15857 19 colony colony NN cord-005453-4057qib7 15857 20 - - HYPH cord-005453-4057qib7 15857 21 stimulating stimulate VBG cord-005453-4057qib7 15857 22 factor factor NN cord-005453-4057qib7 15857 23 [ [ -LRB- cord-005453-4057qib7 15857 24 G G NNP cord-005453-4057qib7 15857 25 - - HYPH cord-005453-4057qib7 15857 26 CSF CSF NNP cord-005453-4057qib7 15857 27 ] ] -RRB- cord-005453-4057qib7 15857 28 administration administration NN cord-005453-4057qib7 15857 29 ) ) -RRB- cord-005453-4057qib7 15857 30 and and CC cord-005453-4057qib7 15857 31 in in IN cord-005453-4057qib7 15857 32 PB PB NNP cord-005453-4057qib7 15857 33 after after IN cord-005453-4057qib7 15857 34 G G NNP cord-005453-4057qib7 15857 35 - - HYPH cord-005453-4057qib7 15857 36 CSF CSF NNP cord-005453-4057qib7 15857 37 administration administration NN cord-005453-4057qib7 15857 38 on on IN cord-005453-4057qib7 15857 39 day day NN cord-005453-4057qib7 15857 40 4 4 CD cord-005453-4057qib7 15857 41 . . . cord-005453-4057qib7 15858 1 A a DT cord-005453-4057qib7 15858 2 total total NN cord-005453-4057qib7 15858 3 of of IN cord-005453-4057qib7 15858 4 122 122 CD cord-005453-4057qib7 15858 5 consecutive consecutive JJ cord-005453-4057qib7 15858 6 HDs hd NNS cord-005453-4057qib7 15858 7 with with IN cord-005453-4057qib7 15858 8 a a DT cord-005453-4057qib7 15858 9 median median JJ cord-005453-4057qib7 15858 10 age age NN cord-005453-4057qib7 15858 11 of of IN cord-005453-4057qib7 15858 12 47.5 47.5 CD cord-005453-4057qib7 15858 13 years year NNS cord-005453-4057qib7 15858 14 were be VBD cord-005453-4057qib7 15858 15 enrolled enrol VBN cord-005453-4057qib7 15858 16 . . . cord-005453-4057qib7 15859 1 Results result NNS cord-005453-4057qib7 15859 2 : : : cord-005453-4057qib7 15860 1 The the DT cord-005453-4057qib7 15860 2 median median JJ cord-005453-4057qib7 15860 3 value value NN cord-005453-4057qib7 15860 4 of of IN cord-005453-4057qib7 15860 5 CD34 CD34 NNP cord-005453-4057qib7 15860 6 + + CC cord-005453-4057qib7 15860 7 on on IN cord-005453-4057qib7 15860 8 day day NN cord-005453-4057qib7 15860 9 4 4 CD cord-005453-4057qib7 15860 10 was be VBD cord-005453-4057qib7 15860 11 43 43 CD cord-005453-4057qib7 15860 12 cells cell NNS cord-005453-4057qib7 15861 1 / / NFP cord-005453-4057qib7 15862 1 μL μL . cord-005453-4057qib7 15863 1 ( ( -LRB- cord-005453-4057qib7 15863 2 IQ IQ NNP cord-005453-4057qib7 15863 3 23 23 CD cord-005453-4057qib7 15863 4 - - SYM cord-005453-4057qib7 15863 5 68 68 CD cord-005453-4057qib7 15863 6 ) ) -RRB- cord-005453-4057qib7 15863 7 . . . cord-005453-4057qib7 15864 1 Basal Basal NNP cord-005453-4057qib7 15864 2 WBC WBC NNP cord-005453-4057qib7 15864 3 , , , cord-005453-4057qib7 15864 4 Plt Plt NNP cord-005453-4057qib7 15864 5 and and CC cord-005453-4057qib7 15864 6 basal basal NN cord-005453-4057qib7 15864 7 CD34 CD34 NNP cord-005453-4057qib7 15865 1 + + CC cord-005453-4057qib7 15865 2 , , , cord-005453-4057qib7 15865 3 are be VBP cord-005453-4057qib7 15865 4 significantly significantly RB cord-005453-4057qib7 15865 5 higher high JJR cord-005453-4057qib7 15865 6 for for IN cord-005453-4057qib7 15865 7 group group NN cord-005453-4057qib7 15865 8 with with IN cord-005453-4057qib7 15865 9 CD34 CD34 NNP cord-005453-4057qib7 15865 10 + + CC cord-005453-4057qib7 15866 1 on on IN cord-005453-4057qib7 15866 2 the the DT cord-005453-4057qib7 15866 3 4th 4th JJ cord-005453-4057qib7 15866 4 day day NN cord-005453-4057qib7 15866 5 over over IN cord-005453-4057qib7 15866 6 the the DT cord-005453-4057qib7 15866 7 median median NN cord-005453-4057qib7 15866 8 than than IN cord-005453-4057qib7 15866 9 below below RB cord-005453-4057qib7 15866 10 . . . cord-005453-4057qib7 15867 1 A a DT cord-005453-4057qib7 15867 2 multivariate multivariate JJ cord-005453-4057qib7 15867 3 quartile quartile NN cord-005453-4057qib7 15867 4 regression regression NN cord-005453-4057qib7 15867 5 analysis analysis NN cord-005453-4057qib7 15867 6 , , , cord-005453-4057qib7 15867 7 adjusted adjust VBN cord-005453-4057qib7 15867 8 by by IN cord-005453-4057qib7 15867 9 gender gender NN cord-005453-4057qib7 15867 10 , , , cord-005453-4057qib7 15867 11 age age NN cord-005453-4057qib7 15867 12 , , , cord-005453-4057qib7 15867 13 basal basal NN cord-005453-4057qib7 15867 14 CD34 CD34 NNP cord-005453-4057qib7 15867 15 + + CC cord-005453-4057qib7 15867 16 and and CC cord-005453-4057qib7 15867 17 basal basal JJ cord-005453-4057qib7 15867 18 Plt Plt NNP cord-005453-4057qib7 15867 19 , , , cord-005453-4057qib7 15867 20 shows show VBZ cord-005453-4057qib7 15867 21 a a DT cord-005453-4057qib7 15867 22 , , , cord-005453-4057qib7 15867 23 progressively progressively RB cord-005453-4057qib7 15867 24 steeper steep JJR cord-005453-4057qib7 15867 25 , , , cord-005453-4057qib7 15867 26 relationship relationship NN cord-005453-4057qib7 15867 27 between between IN cord-005453-4057qib7 15867 28 baseline baseline JJ cord-005453-4057qib7 15867 29 CD34 CD34 NNP cord-005453-4057qib7 15867 30 + + CC cord-005453-4057qib7 15867 31 , , , cord-005453-4057qib7 15867 32 basal basal JJ cord-005453-4057qib7 15867 33 Plt Plt NNP cord-005453-4057qib7 15867 34 and and CC cord-005453-4057qib7 15867 35 CD34 CD34 NNP cord-005453-4057qib7 15867 36 + + CC cord-005453-4057qib7 15868 1 on on IN cord-005453-4057qib7 15868 2 the the DT cord-005453-4057qib7 15868 3 4th 4th JJ cord-005453-4057qib7 15868 4 day day NN cord-005453-4057qib7 15868 5 . . . cord-005453-4057qib7 15869 1 The the DT cord-005453-4057qib7 15869 2 basal basal NN cord-005453-4057qib7 15869 3 CD34 CD34 NNP cord-005453-4057qib7 15869 4 + + CC cord-005453-4057qib7 15870 1 cut cut VB cord-005453-4057qib7 15870 2 - - HYPH cord-005453-4057qib7 15870 3 off off NN cord-005453-4057qib7 15870 4 for for IN cord-005453-4057qib7 15870 5 prevision prevision NN cord-005453-4057qib7 15870 6 of of IN cord-005453-4057qib7 15870 7 CD34 CD34 NNP cord-005453-4057qib7 15870 8 + + CC cord-005453-4057qib7 15871 1 on on IN cord-005453-4057qib7 15871 2 the the DT cord-005453-4057qib7 15871 3 4th 4th JJ cord-005453-4057qib7 15871 4 day day NN cord-005453-4057qib7 15871 5 was be VBD cord-005453-4057qib7 15871 6 < < XX cord-005453-4057qib7 15871 7 = = SYM cord-005453-4057qib7 15871 8 2 2 CD cord-005453-4057qib7 15871 9 cells cell NNS cord-005453-4057qib7 15871 10 / / SYM cord-005453-4057qib7 15871 11 μL μl NN cord-005453-4057qib7 15871 12 and and CC cord-005453-4057qib7 15871 13 > > XX cord-005453-4057qib7 15871 14 =3 =3 NN cord-005453-4057qib7 15871 15 cells/ cells/ . cord-005453-4057qib7 15872 1 μL μL . cord-005453-4057qib7 15873 1 whereas whereas IN cord-005453-4057qib7 15873 2 basal basal NN cord-005453-4057qib7 15873 3 platelets platelet NNS cord-005453-4057qib7 15873 4 count count NN cord-005453-4057qib7 15873 5 was be VBD cord-005453-4057qib7 15874 1 < < XX cord-005453-4057qib7 15874 2 = = SYM cord-005453-4057qib7 15874 3 229 229 CD cord-005453-4057qib7 15874 4 x x SYM cord-005453-4057qib7 15874 5 109 109 CD cord-005453-4057qib7 15874 6 / / SYM cord-005453-4057qib7 15874 7 L l NN cord-005453-4057qib7 15874 8 and and CC cord-005453-4057qib7 15874 9 > > XX cord-005453-4057qib7 15875 1 = = SYM cord-005453-4057qib7 15875 2 230 230 CD cord-005453-4057qib7 15875 3 x x SYM cord-005453-4057qib7 15875 4 109 109 CD cord-005453-4057qib7 15876 1 / / NFP cord-005453-4057qib7 15877 1 L.Conclusions l.conclusion NNS cord-005453-4057qib7 15877 2 : : : cord-005453-4057qib7 15877 3 G G NNP cord-005453-4057qib7 15877 4 - - HYPH cord-005453-4057qib7 15877 5 CSF CSF NNP cord-005453-4057qib7 15877 6 can can MD cord-005453-4057qib7 15877 7 be be VB cord-005453-4057qib7 15877 8 highly highly RB cord-005453-4057qib7 15877 9 effective effective JJ cord-005453-4057qib7 15877 10 in in IN cord-005453-4057qib7 15877 11 HDs hd NNS cord-005453-4057qib7 15877 12 on on IN cord-005453-4057qib7 15877 13 the the DT cord-005453-4057qib7 15877 14 4th 4th JJ cord-005453-4057qib7 15877 15 day day NN cord-005453-4057qib7 15877 16 in in IN cord-005453-4057qib7 15877 17 order order NN cord-005453-4057qib7 15877 18 to to TO cord-005453-4057qib7 15877 19 collect collect VB cord-005453-4057qib7 15877 20 enough enough JJ cord-005453-4057qib7 15877 21 number number NN cord-005453-4057qib7 15877 22 of of IN cord-005453-4057qib7 15877 23 stem stem NN cord-005453-4057qib7 15877 24 cells cell NNS cord-005453-4057qib7 15877 25 and and CC cord-005453-4057qib7 15877 26 we -PRON- PRP cord-005453-4057qib7 15877 27 have have VBP cord-005453-4057qib7 15877 28 developed develop VBN cord-005453-4057qib7 15877 29 a a DT cord-005453-4057qib7 15877 30 model model NN cord-005453-4057qib7 15877 31 for for IN cord-005453-4057qib7 15877 32 predicting predict VBG cord-005453-4057qib7 15877 33 the the DT cord-005453-4057qib7 15877 34 probability probability NN cord-005453-4057qib7 15877 35 to to TO cord-005453-4057qib7 15877 36 perform perform VB cord-005453-4057qib7 15877 37 PBSC PBSC NNP cord-005453-4057qib7 15877 38 collection collection NN cord-005453-4057qib7 15877 39 after after IN cord-005453-4057qib7 15877 40 a a DT cord-005453-4057qib7 15877 41 short short JJ cord-005453-4057qib7 15877 42 course course NN cord-005453-4057qib7 15877 43 of of IN cord-005453-4057qib7 15877 44 G g NN cord-005453-4057qib7 15877 45 - - HYPH cord-005453-4057qib7 15877 46 CSF.Disclosure csf.disclosure NN cord-005453-4057qib7 15877 47 : : : cord-005453-4057qib7 15877 48 nothing nothing NN cord-005453-4057qib7 15877 49 to to TO cord-005453-4057qib7 15877 50 declare declare VB cord-005453-4057qib7 15877 51 P692 p692 JJ cord-005453-4057qib7 15877 52 Pre pre NN cord-005453-4057qib7 15877 53 - - JJ cord-005453-4057qib7 15877 54 apheresis apheresis JJ cord-005453-4057qib7 15877 55 peripheral peripheral JJ cord-005453-4057qib7 15877 56 blood blood NN cord-005453-4057qib7 15877 57 CD34 CD34 NNP cord-005453-4057qib7 15877 58 + + CC cord-005453-4057qib7 15877 59 cell cell NN cord-005453-4057qib7 15877 60 counts count VBZ cord-005453-4057qib7 15877 61 highly highly RB cord-005453-4057qib7 15877 62 correlates correlate VBZ cord-005453-4057qib7 15877 63 to to IN cord-005453-4057qib7 15877 64 actual actual JJ cord-005453-4057qib7 15877 65 stem stem NN cord-005453-4057qib7 15877 66 cells cell NNS cord-005453-4057qib7 15877 67 collected collect VBD cord-005453-4057qib7 15877 68 Background Background NNP cord-005453-4057qib7 15877 69 : : : cord-005453-4057qib7 15878 1 Prediction prediction NN cord-005453-4057qib7 15878 2 of of IN cord-005453-4057qib7 15878 3 stem stem NN cord-005453-4057qib7 15878 4 cell cell NN cord-005453-4057qib7 15878 5 yield yield NN cord-005453-4057qib7 15878 6 on on IN cord-005453-4057qib7 15878 7 the the DT cord-005453-4057qib7 15878 8 basis basis NN cord-005453-4057qib7 15878 9 of of IN cord-005453-4057qib7 15878 10 pre pre JJ cord-005453-4057qib7 15878 11 - - JJ cord-005453-4057qib7 15878 12 apheresis apheresis NN cord-005453-4057qib7 15878 13 CD34 CD34 NNP cord-005453-4057qib7 15878 14 + + CC cord-005453-4057qib7 15878 15 cell cell NN cord-005453-4057qib7 15878 16 count count NN cord-005453-4057qib7 15878 17 and and CC cord-005453-4057qib7 15878 18 the the DT cord-005453-4057qib7 15878 19 processed process VBN cord-005453-4057qib7 15878 20 blood blood NN cord-005453-4057qib7 15878 21 volume volume NN cord-005453-4057qib7 15878 22 is be VBZ cord-005453-4057qib7 15878 23 essential essential JJ cord-005453-4057qib7 15878 24 for for IN cord-005453-4057qib7 15878 25 the the DT cord-005453-4057qib7 15878 26 planning planning NN cord-005453-4057qib7 15878 27 and and CC cord-005453-4057qib7 15878 28 executing executing NN cord-005453-4057qib7 15878 29 of of IN cord-005453-4057qib7 15878 30 the the DT cord-005453-4057qib7 15878 31 apheresis apheresis NN cord-005453-4057qib7 15878 32 process process NN cord-005453-4057qib7 15878 33 . . . cord-005453-4057qib7 15879 1 Methods method NNS cord-005453-4057qib7 15879 2 : : : cord-005453-4057qib7 15880 1 Data datum NNS cord-005453-4057qib7 15880 2 analyzed analyze VBD cord-005453-4057qib7 15880 3 included include VBN cord-005453-4057qib7 15880 4 donor donor NN cord-005453-4057qib7 15880 5 weight weight NN cord-005453-4057qib7 15880 6 , , , cord-005453-4057qib7 15880 7 complete complete JJ cord-005453-4057qib7 15880 8 blood blood NN cord-005453-4057qib7 15880 9 count count NN cord-005453-4057qib7 15880 10 and and CC cord-005453-4057qib7 15880 11 CD34 CD34 NNP cord-005453-4057qib7 15880 12 + + CC cord-005453-4057qib7 15880 13 count count NN cord-005453-4057qib7 15880 14 on on IN cord-005453-4057qib7 15880 15 day day NN cord-005453-4057qib7 15880 16 of of IN cord-005453-4057qib7 15880 17 collection collection NN cord-005453-4057qib7 15880 18 , , , cord-005453-4057qib7 15880 19 total total JJ cord-005453-4057qib7 15880 20 processed process VBN cord-005453-4057qib7 15880 21 blood blood NN cord-005453-4057qib7 15880 22 volume volume NN cord-005453-4057qib7 15880 23 , , , cord-005453-4057qib7 15880 24 CD34 CD34 NNP cord-005453-4057qib7 15880 25 + + CC cord-005453-4057qib7 15880 26 cell cell NN cord-005453-4057qib7 15880 27 dose dose NN cord-005453-4057qib7 15880 28 collected collect VBN cord-005453-4057qib7 15880 29 in in IN cord-005453-4057qib7 15880 30 the the DT cord-005453-4057qib7 15880 31 apheresis apheresis NN cord-005453-4057qib7 15880 32 product product NN cord-005453-4057qib7 15880 33 and and CC cord-005453-4057qib7 15880 34 the the DT cord-005453-4057qib7 15880 35 number number NN cord-005453-4057qib7 15880 36 of of IN cord-005453-4057qib7 15880 37 aphereses apherese NNS cord-005453-4057qib7 15880 38 performed perform VBN cord-005453-4057qib7 15880 39 . . . cord-005453-4057qib7 15881 1 Using use VBG cord-005453-4057qib7 15881 2 the the DT cord-005453-4057qib7 15881 3 method method NN cord-005453-4057qib7 15881 4 described describe VBN cord-005453-4057qib7 15881 5 by by IN cord-005453-4057qib7 15881 6 Pierelli Pierelli NNP cord-005453-4057qib7 15881 7 et et NNP cord-005453-4057qib7 15881 8 al al NNP cord-005453-4057qib7 15881 9 , , , cord-005453-4057qib7 15881 10 predicted predict VBD cord-005453-4057qib7 15881 11 CD34 CD34 NNP cord-005453-4057qib7 15881 12 + + CC cord-005453-4057qib7 15881 13 yields yield NNS cord-005453-4057qib7 15881 14 were be VBD cord-005453-4057qib7 15881 15 calculated calculate VBN cord-005453-4057qib7 15881 16 : : : cord-005453-4057qib7 15881 17 Predicted predict VBN cord-005453-4057qib7 15881 18 CD34 CD34 NNP cord-005453-4057qib7 15881 19 + + CC cord-005453-4057qib7 15881 20 yield yield NN cord-005453-4057qib7 15881 21 x x SYM cord-005453-4057qib7 15881 22 106 106 CD cord-005453-4057qib7 15881 23 / / SYM cord-005453-4057qib7 15881 24 kg kg NN cord-005453-4057qib7 15881 25 = = NFP cord-005453-4057qib7 15882 1 ( ( -LRB- cord-005453-4057qib7 15882 2 Benchmark Benchmark NNP cord-005453-4057qib7 15882 3 CE CE NNP cord-005453-4057qib7 15882 4 x x NN cord-005453-4057qib7 15882 5 Volume volume NN cord-005453-4057qib7 15882 6 of of IN cord-005453-4057qib7 15882 7 blood blood NN cord-005453-4057qib7 15882 8 to to TO cord-005453-4057qib7 15882 9 be be VB cord-005453-4057qib7 15882 10 processed process VBN cord-005453-4057qib7 15883 1 x x LS cord-005453-4057qib7 15883 2 peripheral peripheral JJ cord-005453-4057qib7 15883 3 CD34 CD34 NNP cord-005453-4057qib7 15884 1 + + CC cord-005453-4057qib7 15884 2 count count NN cord-005453-4057qib7 15884 3 per per IN cord-005453-4057qib7 15884 4 μl μl NN cord-005453-4057qib7 15884 5 ) ) -RRB- cord-005453-4057qib7 15884 6 / / . cord-005453-4057qib7 15885 1 ( ( -LRB- cord-005453-4057qib7 15885 2 Patient Patient NNP cord-005453-4057qib7 15885 3 's 's POS cord-005453-4057qib7 15885 4 weight weight NN cord-005453-4057qib7 15885 5 in in IN cord-005453-4057qib7 15885 6 kg kg NN cord-005453-4057qib7 15885 7 x x NN cord-005453-4057qib7 15885 8 metric metric JJ cord-005453-4057qib7 15885 9 conversion conversion NN cord-005453-4057qib7 15885 10 factor).Results factor).Results NNP cord-005453-4057qib7 15885 11 : : : cord-005453-4057qib7 15886 1 In in IN cord-005453-4057qib7 15886 2 2017 2017 CD cord-005453-4057qib7 15886 3 we -PRON- PRP cord-005453-4057qib7 15886 4 established establish VBD cord-005453-4057qib7 15886 5 the the DT cord-005453-4057qib7 15886 6 method method NN cord-005453-4057qib7 15886 7 described describe VBN cord-005453-4057qib7 15886 8 by by IN cord-005453-4057qib7 15886 9 Pierelli Pierelli NNP cord-005453-4057qib7 15886 10 to to TO cord-005453-4057qib7 15886 11 predict predict VB cord-005453-4057qib7 15886 12 the the DT cord-005453-4057qib7 15886 13 CD34 CD34 NNP cord-005453-4057qib7 15886 14 + + CC cord-005453-4057qib7 15886 15 cell cell NN cord-005453-4057qib7 15886 16 yield yield NN cord-005453-4057qib7 15886 17 . . . cord-005453-4057qib7 15887 1 323 323 CD cord-005453-4057qib7 15887 2 allogenic allogenic JJ cord-005453-4057qib7 15887 3 aphereses apherese NNS cord-005453-4057qib7 15887 4 were be VBD cord-005453-4057qib7 15887 5 performed perform VBN cord-005453-4057qib7 15887 6 in in IN cord-005453-4057qib7 15887 7 2017 2017 CD cord-005453-4057qib7 15887 8 with with IN cord-005453-4057qib7 15887 9 this this DT cord-005453-4057qib7 15887 10 approach approach NN cord-005453-4057qib7 15887 11 . . . cord-005453-4057qib7 15888 1 Mean mean JJ cord-005453-4057qib7 15888 2 processed process VBN cord-005453-4057qib7 15888 3 volume volume NN cord-005453-4057qib7 15888 4 was be VBD cord-005453-4057qib7 15888 5 13.71 13.71 CD cord-005453-4057qib7 15888 6 Liters Liters NNPS cord-005453-4057qib7 15888 7 . . . cord-005453-4057qib7 15889 1 The the DT cord-005453-4057qib7 15889 2 mean mean JJ cord-005453-4057qib7 15889 3 CD34 CD34 NNP cord-005453-4057qib7 15889 4 + + CC cord-005453-4057qib7 15889 5 peripheral peripheral JJ cord-005453-4057qib7 15889 6 count count NN cord-005453-4057qib7 15889 7 before before IN cord-005453-4057qib7 15889 8 apheresis apheresis NN cord-005453-4057qib7 15889 9 was be VBD cord-005453-4057qib7 15889 10 68 68 CD cord-005453-4057qib7 15889 11 / / SYM cord-005453-4057qib7 15889 12 ul ul NN cord-005453-4057qib7 15889 13 , , , cord-005453-4057qib7 15889 14 the the DT cord-005453-4057qib7 15889 15 mean mean NN cord-005453-4057qib7 15889 16 collected collect VBD cord-005453-4057qib7 15889 17 CD34+count CD34+count NNP cord-005453-4057qib7 15889 18 per per IN cord-005453-4057qib7 15890 1 kg kg NNP cord-005453-4057qib7 15890 2 bodyweight bodyweight NNP cord-005453-4057qib7 15890 3 recipient recipient NN cord-005453-4057qib7 15890 4 was be VBD cord-005453-4057qib7 15890 5 6.35 6.35 CD cord-005453-4057qib7 15890 6 . . . cord-005453-4057qib7 15891 1 Pearson´s pearson´s JJ cord-005453-4057qib7 15891 2 correlation correlation NN cord-005453-4057qib7 15891 3 coefficient coefficient NN cord-005453-4057qib7 15891 4 ( ( -LRB- cord-005453-4057qib7 15891 5 r r NN cord-005453-4057qib7 15891 6 ) ) -RRB- cord-005453-4057qib7 15891 7 between between IN cord-005453-4057qib7 15891 8 predicted predict VBN cord-005453-4057qib7 15891 9 yield yield NN cord-005453-4057qib7 15891 10 using use VBG cord-005453-4057qib7 15891 11 pre pre JJ cord-005453-4057qib7 15891 12 - - JJ cord-005453-4057qib7 15891 13 apheresis apheresis JJ cord-005453-4057qib7 15891 14 CD34+count CD34+count NNP cord-005453-4057qib7 15891 15 and and CC cord-005453-4057qib7 15891 16 actually actually RB cord-005453-4057qib7 15891 17 collected collect VBD cord-005453-4057qib7 15891 18 CD34 CD34 NNP cord-005453-4057qib7 15891 19 + + CC cord-005453-4057qib7 15892 1 cells cell NNS cord-005453-4057qib7 15892 2 per per IN cord-005453-4057qib7 15892 3 kg kg NNP cord-005453-4057qib7 15892 4 bodyweight bodyweight NN cord-005453-4057qib7 15892 5 recipient recipient NN cord-005453-4057qib7 15892 6 was be VBD cord-005453-4057qib7 15892 7 0.967 0.967 CD cord-005453-4057qib7 15892 8 . . . cord-005453-4057qib7 15893 1 The the DT cord-005453-4057qib7 15893 2 mean mean JJ cord-005453-4057qib7 15893 3 difference difference NN cord-005453-4057qib7 15893 4 between between IN cord-005453-4057qib7 15893 5 predicted predict VBN cord-005453-4057qib7 15893 6 and and CC cord-005453-4057qib7 15893 7 collected collect VBN cord-005453-4057qib7 15893 8 cell cell NN cord-005453-4057qib7 15893 9 dose dose NN cord-005453-4057qib7 15893 10 was be VBD cord-005453-4057qib7 15893 11 +4.45%.With +4.45%.with ADD cord-005453-4057qib7 15893 12 knowledge knowledge NN cord-005453-4057qib7 15893 13 of of IN cord-005453-4057qib7 15893 14 the the DT cord-005453-4057qib7 15893 15 predicted predict VBN cord-005453-4057qib7 15893 16 stem stem NN cord-005453-4057qib7 15893 17 cell cell NN cord-005453-4057qib7 15893 18 count count NN cord-005453-4057qib7 15893 19 , , , cord-005453-4057qib7 15893 20 we -PRON- PRP cord-005453-4057qib7 15893 21 were be VBD cord-005453-4057qib7 15893 22 able able JJ cord-005453-4057qib7 15893 23 to to TO cord-005453-4057qib7 15893 24 adjust adjust VB cord-005453-4057qib7 15893 25 apheresis apheresis NN cord-005453-4057qib7 15893 26 procedure procedure NN cord-005453-4057qib7 15893 27 . . . cord-005453-4057qib7 15894 1 In in IN cord-005453-4057qib7 15894 2 case case NN cord-005453-4057qib7 15894 3 of of IN cord-005453-4057qib7 15894 4 marginal marginal JJ cord-005453-4057qib7 15894 5 predicted predict VBN cord-005453-4057qib7 15894 6 yield yield NN cord-005453-4057qib7 15894 7 compared compare VBN cord-005453-4057qib7 15894 8 to to IN cord-005453-4057qib7 15894 9 the the DT cord-005453-4057qib7 15894 10 requested request VBN cord-005453-4057qib7 15894 11 cell cell NN cord-005453-4057qib7 15894 12 dose dose NN cord-005453-4057qib7 15894 13 , , , cord-005453-4057qib7 15894 14 we -PRON- PRP cord-005453-4057qib7 15894 15 increased increase VBD cord-005453-4057qib7 15894 16 the the DT cord-005453-4057qib7 15894 17 blood blood NN cord-005453-4057qib7 15894 18 volume volume NN cord-005453-4057qib7 15894 19 to to TO cord-005453-4057qib7 15894 20 be be VB cord-005453-4057qib7 15894 21 processed process VBN cord-005453-4057qib7 15894 22 . . . cord-005453-4057qib7 15895 1 This this DT cord-005453-4057qib7 15895 2 proceeding proceeding NN cord-005453-4057qib7 15895 3 led lead VBD cord-005453-4057qib7 15895 4 to to IN cord-005453-4057qib7 15895 5 a a DT cord-005453-4057qib7 15895 6 significant significant JJ cord-005453-4057qib7 15895 7 reduction reduction NN cord-005453-4057qib7 15895 8 of of IN cord-005453-4057qib7 15895 9 second second JJ cord-005453-4057qib7 15895 10 day day NN cord-005453-4057qib7 15895 11 donations donation NNS cord-005453-4057qib7 15895 12 in in IN cord-005453-4057qib7 15895 13 2017 2017 CD cord-005453-4057qib7 15895 14 by by IN cord-005453-4057qib7 15895 15 38 38 CD cord-005453-4057qib7 15895 16 % % NN cord-005453-4057qib7 15895 17 compared compare VBN cord-005453-4057qib7 15895 18 to to IN cord-005453-4057qib7 15895 19 2016 2016 CD cord-005453-4057qib7 15895 20 . . . cord-005453-4057qib7 15896 1 In in IN cord-005453-4057qib7 15896 2 only only RB cord-005453-4057qib7 15896 3 3 3 CD cord-005453-4057qib7 15896 4 cases case NNS cord-005453-4057qib7 15896 5 we -PRON- PRP cord-005453-4057qib7 15896 6 saw see VBD cord-005453-4057qib7 15896 7 more more JJR cord-005453-4057qib7 15896 8 than than IN cord-005453-4057qib7 15896 9 -40 -40 NNS cord-005453-4057qib7 15896 10 % % NN cord-005453-4057qib7 15896 11 lower low JJR cord-005453-4057qib7 15896 12 CD34 CD34 NNP cord-005453-4057qib7 15896 13 + + CC cord-005453-4057qib7 15896 14 doses dose NNS cord-005453-4057qib7 15896 15 collected collect VBN cord-005453-4057qib7 15896 16 than than IN cord-005453-4057qib7 15896 17 initially initially RB cord-005453-4057qib7 15896 18 predicted predict VBN cord-005453-4057qib7 15896 19 . . . cord-005453-4057qib7 15897 1 All all DT cord-005453-4057qib7 15897 2 3 3 CD cord-005453-4057qib7 15897 3 donors donor NNS cord-005453-4057qib7 15897 4 showed show VBD cord-005453-4057qib7 15897 5 mild mild JJ cord-005453-4057qib7 15897 6 iron iron NN cord-005453-4057qib7 15897 7 deficiency deficiency NN cord-005453-4057qib7 15897 8 with with IN cord-005453-4057qib7 15897 9 RBC RBC NNP cord-005453-4057qib7 15897 10 microcytosis microcytosis NNP cord-005453-4057qib7 15897 11 , , , cord-005453-4057qib7 15897 12 a a DT cord-005453-4057qib7 15897 13 factor factor NN cord-005453-4057qib7 15897 14 known know VBN cord-005453-4057qib7 15897 15 to to TO cord-005453-4057qib7 15897 16 affect affect VB cord-005453-4057qib7 15897 17 apheresis apheresis NN cord-005453-4057qib7 15897 18 procedure procedure NN cord-005453-4057qib7 15897 19 . . . cord-005453-4057qib7 15898 1 Conclusions conclusion NNS cord-005453-4057qib7 15898 2 : : : cord-005453-4057qib7 15899 1 Pierellis Pierellis NNP cord-005453-4057qib7 15899 2 method method NN cord-005453-4057qib7 15899 3 of of IN cord-005453-4057qib7 15899 4 calculating calculate VBG cord-005453-4057qib7 15899 5 the the DT cord-005453-4057qib7 15899 6 stem stem NN cord-005453-4057qib7 15899 7 cell cell NN cord-005453-4057qib7 15899 8 yield yield NN cord-005453-4057qib7 15899 9 shows show VBZ cord-005453-4057qib7 15899 10 a a DT cord-005453-4057qib7 15899 11 good good JJ cord-005453-4057qib7 15899 12 correlation correlation NN cord-005453-4057qib7 15899 13 between between IN cord-005453-4057qib7 15899 14 pre pre JJ cord-005453-4057qib7 15899 15 - - JJ cord-005453-4057qib7 15899 16 apheresis apheresis NN cord-005453-4057qib7 15899 17 CD34 CD34 NNP cord-005453-4057qib7 15899 18 + + CC cord-005453-4057qib7 15899 19 count count NN cord-005453-4057qib7 15899 20 and and CC cord-005453-4057qib7 15899 21 actual actual JJ cord-005453-4057qib7 15899 22 collected collect VBN cord-005453-4057qib7 15899 23 stem stem NN cord-005453-4057qib7 15899 24 cells cell NNS cord-005453-4057qib7 15899 25 , , , cord-005453-4057qib7 15899 26 making make VBG cord-005453-4057qib7 15899 27 planning planning NN cord-005453-4057qib7 15899 28 and and CC cord-005453-4057qib7 15899 29 adjusting adjusting NN cord-005453-4057qib7 15899 30 of of IN cord-005453-4057qib7 15899 31 the the DT cord-005453-4057qib7 15899 32 apheresis apheresis NN cord-005453-4057qib7 15899 33 procedure procedure NN cord-005453-4057qib7 15899 34 more more RBR cord-005453-4057qib7 15899 35 feasible feasible JJ cord-005453-4057qib7 15899 36 and and CC cord-005453-4057qib7 15899 37 reliable reliable JJ cord-005453-4057qib7 15899 38 . . . cord-005453-4057qib7 15900 1 This this DT cord-005453-4057qib7 15900 2 proceeding proceeding NN cord-005453-4057qib7 15900 3 led lead VBD cord-005453-4057qib7 15900 4 to to IN cord-005453-4057qib7 15900 5 significant significant JJ cord-005453-4057qib7 15900 6 reduction reduction NN cord-005453-4057qib7 15900 7 of of IN cord-005453-4057qib7 15900 8 second second JJ cord-005453-4057qib7 15900 9 day day NN cord-005453-4057qib7 15900 10 donations donation NNS cord-005453-4057qib7 15900 11 . . . cord-005453-4057qib7 15901 1 Attention attention NN cord-005453-4057qib7 15901 2 should should MD cord-005453-4057qib7 15901 3 be be VB cord-005453-4057qib7 15901 4 paid pay VBN cord-005453-4057qib7 15901 5 to to TO cord-005453-4057qib7 15901 6 iron iron NN cord-005453-4057qib7 15901 7 deficiency deficiency NN cord-005453-4057qib7 15901 8 anemia anemia NN cord-005453-4057qib7 15901 9 , , , cord-005453-4057qib7 15901 10 leading lead VBG cord-005453-4057qib7 15901 11 to to IN cord-005453-4057qib7 15901 12 lower low JJR cord-005453-4057qib7 15901 13 than than IN cord-005453-4057qib7 15901 14 estimated estimate VBN cord-005453-4057qib7 15901 15 CD34 CD34 NNP cord-005453-4057qib7 15901 16 + + CC cord-005453-4057qib7 15901 17 dose dose NN cord-005453-4057qib7 15901 18 . . . cord-005453-4057qib7 15902 1 [ [ -LRB- cord-005453-4057qib7 15902 2 Background background NN cord-005453-4057qib7 15902 3 : : : cord-005453-4057qib7 15903 1 For for IN cord-005453-4057qib7 15903 2 more more JJR cord-005453-4057qib7 15903 3 than than IN cord-005453-4057qib7 15903 4 a a DT cord-005453-4057qib7 15903 5 decade decade NN cord-005453-4057qib7 15903 6 many many JJ cord-005453-4057qib7 15903 7 transplant transplant NN cord-005453-4057qib7 15903 8 centers center NNS cord-005453-4057qib7 15903 9 routinely routinely RB cord-005453-4057qib7 15903 10 collect collect VBP cord-005453-4057qib7 15903 11 and and CC cord-005453-4057qib7 15903 12 cryopreserve cryopreserve VBP cord-005453-4057qib7 15903 13 two two CD cord-005453-4057qib7 15903 14 or or CC cord-005453-4057qib7 15903 15 more more JJR cord-005453-4057qib7 15903 16 peripheral peripheral JJ cord-005453-4057qib7 15903 17 blood blood NN cord-005453-4057qib7 15903 18 stem stem NN cord-005453-4057qib7 15903 19 cell cell NN cord-005453-4057qib7 15903 20 ( ( -LRB- cord-005453-4057qib7 15903 21 PBSC PBSC NNP cord-005453-4057qib7 15903 22 ) ) -RRB- cord-005453-4057qib7 15903 23 grafts graft NNS cord-005453-4057qib7 15903 24 for for IN cord-005453-4057qib7 15903 25 a a DT cord-005453-4057qib7 15903 26 tandem tandem JJ cord-005453-4057qib7 15903 27 and/ and/ CD cord-005453-4057qib7 15903 28 or or CC cord-005453-4057qib7 15903 29 salvage salvage VB cord-005453-4057qib7 15903 30 autologous autologous JJ cord-005453-4057qib7 15903 31 blood blood NN cord-005453-4057qib7 15903 32 stem stem NN cord-005453-4057qib7 15903 33 cell cell NN cord-005453-4057qib7 15903 34 transplantation transplantation NN cord-005453-4057qib7 15903 35 ( ( -LRB- cord-005453-4057qib7 15903 36 ABSCT ABSCT NNP cord-005453-4057qib7 15903 37 ) ) -RRB- cord-005453-4057qib7 15903 38 in in IN cord-005453-4057qib7 15903 39 patients patient NNS cord-005453-4057qib7 15903 40 with with IN cord-005453-4057qib7 15903 41 hemato hemato JJ cord-005453-4057qib7 15903 42 - - HYPH cord-005453-4057qib7 15903 43 oncological oncological JJ cord-005453-4057qib7 15903 44 diseases disease NNS cord-005453-4057qib7 15903 45 . . . cord-005453-4057qib7 15904 1 However however RB cord-005453-4057qib7 15904 2 , , , cord-005453-4057qib7 15904 3 subsequent subsequent JJ cord-005453-4057qib7 15904 4 high high JJ cord-005453-4057qib7 15904 5 - - HYPH cord-005453-4057qib7 15904 6 dose dose NN cord-005453-4057qib7 15904 7 chemotherapy chemotherapy NN cord-005453-4057qib7 15904 8 ( ( -LRB- cord-005453-4057qib7 15904 9 HD hd NN cord-005453-4057qib7 15904 10 - - HYPH cord-005453-4057qib7 15904 11 CHT CHT NNP cord-005453-4057qib7 15904 12 ) ) -RRB- cord-005453-4057qib7 15904 13 and and CC cord-005453-4057qib7 15904 14 ABSCT ABSCT NNP cord-005453-4057qib7 15904 15 is be VBZ cord-005453-4057qib7 15904 16 in in IN cord-005453-4057qib7 15904 17 many many JJ cord-005453-4057qib7 15904 18 cases case NNS cord-005453-4057qib7 15904 19 not not RB cord-005453-4057qib7 15904 20 performed perform VBN cord-005453-4057qib7 15904 21 for for IN cord-005453-4057qib7 15904 22 a a DT cord-005453-4057qib7 15904 23 variety variety NN cord-005453-4057qib7 15904 24 of of IN cord-005453-4057qib7 15904 25 reasons reason NNS cord-005453-4057qib7 15904 26 , , , cord-005453-4057qib7 15904 27 specifically specifically RB cord-005453-4057qib7 15904 28 in in IN cord-005453-4057qib7 15904 29 patients patient NNS cord-005453-4057qib7 15904 30 with with IN cord-005453-4057qib7 15904 31 AML AML NNP cord-005453-4057qib7 15904 32 , , , cord-005453-4057qib7 15904 33 ALL all DT cord-005453-4057qib7 15904 34 , , , cord-005453-4057qib7 15904 35 MPN MPN NNP cord-005453-4057qib7 15904 36 and and CC cord-005453-4057qib7 15904 37 Burkitt Burkitt NNP cord-005453-4057qib7 15904 38 lymphoma lymphoma NN cord-005453-4057qib7 15904 39 . . . cord-005453-4057qib7 15905 1 Data datum NNS cord-005453-4057qib7 15905 2 about about IN cord-005453-4057qib7 15905 3 the the DT cord-005453-4057qib7 15905 4 actual actual JJ cord-005453-4057qib7 15905 5 utilization utilization NN cord-005453-4057qib7 15905 6 rate rate NN cord-005453-4057qib7 15905 7 of of IN cord-005453-4057qib7 15905 8 the the DT cord-005453-4057qib7 15905 9 cryostored cryostore VBN cord-005453-4057qib7 15905 10 stem stem NN cord-005453-4057qib7 15905 11 cell cell NN cord-005453-4057qib7 15905 12 products product NNS cord-005453-4057qib7 15905 13 are be VBP cord-005453-4057qib7 15905 14 lacking lack VBG cord-005453-4057qib7 15905 15 . . . cord-005453-4057qib7 15906 1 Methods method NNS cord-005453-4057qib7 15906 2 : : : cord-005453-4057qib7 15906 3 We -PRON- PRP cord-005453-4057qib7 15906 4 retrospectively retrospectively RB cord-005453-4057qib7 15906 5 analyzed analyze VBD cord-005453-4057qib7 15906 6 the the DT cord-005453-4057qib7 15906 7 collection collection NN cord-005453-4057qib7 15906 8 , , , cord-005453-4057qib7 15906 9 storage storage NN cord-005453-4057qib7 15906 10 and and CC cord-005453-4057qib7 15906 11 disposal disposal NN cord-005453-4057qib7 15906 12 practices practice NNS cord-005453-4057qib7 15906 13 of of IN cord-005453-4057qib7 15906 14 PBSC PBSC NNP cord-005453-4057qib7 15906 15 products product NNS cord-005453-4057qib7 15906 16 from from IN cord-005453-4057qib7 15906 17 a a DT cord-005453-4057qib7 15906 18 large large JJ cord-005453-4057qib7 15906 19 cohort cohort NN cord-005453-4057qib7 15906 20 of of IN cord-005453-4057qib7 15906 21 patients patient NNS cord-005453-4057qib7 15906 22 who who WP cord-005453-4057qib7 15906 23 were be VBD cord-005453-4057qib7 15906 24 treated treat VBN cord-005453-4057qib7 15906 25 at at IN cord-005453-4057qib7 15906 26 the the DT cord-005453-4057qib7 15906 27 University University NNP cord-005453-4057qib7 15906 28 Hospital Hospital NNP cord-005453-4057qib7 15906 29 Heidelberg Heidelberg NNP cord-005453-4057qib7 15906 30 or or CC cord-005453-4057qib7 15906 31 at at IN cord-005453-4057qib7 15906 32 the the DT cord-005453-4057qib7 15906 33 University University NNP cord-005453-4057qib7 15906 34 Medical Medical NNP cord-005453-4057qib7 15906 35 Center Center NNP cord-005453-4057qib7 15906 36 Mannheim Mannheim NNP cord-005453-4057qib7 15906 37 during during IN cord-005453-4057qib7 15906 38 a a DT cord-005453-4057qib7 15906 39 12-year 12-year JJ cord-005453-4057qib7 15906 40 period period NN cord-005453-4057qib7 15906 41 . . . cord-005453-4057qib7 15907 1 Disease Disease NNP cord-005453-4057qib7 15907 2 entities entity NNS cord-005453-4057qib7 15907 3 included include VBD cord-005453-4057qib7 15907 4 acute acute JJ cord-005453-4057qib7 15907 5 myeloid myeloid NN cord-005453-4057qib7 15907 6 leukemia leukemia NN cord-005453-4057qib7 15907 7 ( ( -LRB- cord-005453-4057qib7 15907 8 AML AML NNP cord-005453-4057qib7 15907 9 , , , cord-005453-4057qib7 15907 10 n=74 n=74 NNP cord-005453-4057qib7 15907 11 ) ) -RRB- cord-005453-4057qib7 15907 12 , , , cord-005453-4057qib7 15907 13 acute acute JJ cord-005453-4057qib7 15907 14 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 15907 15 leukemia leukemia NN cord-005453-4057qib7 15907 16 ( ( -LRB- cord-005453-4057qib7 15907 17 ALL all DT cord-005453-4057qib7 15907 18 , , , cord-005453-4057qib7 15907 19 n=22 n=22 NNP cord-005453-4057qib7 15907 20 ) ) -RRB- cord-005453-4057qib7 15907 21 , , , cord-005453-4057qib7 15907 22 MPN MPN NNP cord-005453-4057qib7 15907 23 ( ( -LRB- cord-005453-4057qib7 15907 24 n=18 n=18 RB cord-005453-4057qib7 15907 25 ; ; , cord-005453-4057qib7 15907 26 primary primary JJ cord-005453-4057qib7 15907 27 myelofibrosis myelofibrosis NN cord-005453-4057qib7 15907 28 [ [ -LRB- cord-005453-4057qib7 15907 29 PMF PMF NNP cord-005453-4057qib7 15907 30 ] ] -RRB- cord-005453-4057qib7 15907 31 , , , cord-005453-4057qib7 15907 32 n=9 n=9 JJ cord-005453-4057qib7 15907 33 ; ; : cord-005453-4057qib7 15907 34 chronic chronic JJ cord-005453-4057qib7 15907 35 myeloid myeloid NN cord-005453-4057qib7 15907 36 leukemia leukemia NN cord-005453-4057qib7 15907 37 [ [ -LRB- cord-005453-4057qib7 15907 38 CML CML NNP cord-005453-4057qib7 15907 39 ] ] -RRB- cord-005453-4057qib7 15907 40 , , , cord-005453-4057qib7 15907 41 n=7 n=7 JJ cord-005453-4057qib7 15907 42 ; ; , cord-005453-4057qib7 15907 43 secondary secondary JJ cord-005453-4057qib7 15907 44 fibrosis fibrosis NN cord-005453-4057qib7 15907 45 / / SYM cord-005453-4057qib7 15907 46 essential essential JJ cord-005453-4057qib7 15907 47 thrombocythemia thrombocythemia NN cord-005453-4057qib7 15907 48 [ [ -LRB- cord-005453-4057qib7 15907 49 ET ET NNP cord-005453-4057qib7 15907 50 ] ] -RRB- cord-005453-4057qib7 15907 51 , , , cord-005453-4057qib7 15907 52 n=1 n=1 FW cord-005453-4057qib7 15907 53 ; ; : cord-005453-4057qib7 15907 54 not not RB cord-005453-4057qib7 15907 55 specified specify VBN cord-005453-4057qib7 15907 56 , , , cord-005453-4057qib7 15907 57 n=1 n=1 CD cord-005453-4057qib7 15907 58 ) ) -RRB- cord-005453-4057qib7 15907 59 and and CC cord-005453-4057qib7 15907 60 Burkitt Burkitt NNP cord-005453-4057qib7 15907 61 lymphoma lymphoma NN cord-005453-4057qib7 15907 62 ( ( -LRB- cord-005453-4057qib7 15907 63 n=18 n=18 RB cord-005453-4057qib7 15907 64 ) ) -RRB- cord-005453-4057qib7 15907 65 . . . cord-005453-4057qib7 15908 1 Patients patient NNS cord-005453-4057qib7 15908 2 between between IN cord-005453-4057qib7 15908 3 2001 2001 CD cord-005453-4057qib7 15908 4 and and CC cord-005453-4057qib7 15908 5 2012 2012 CD cord-005453-4057qib7 15908 6 were be VBD cord-005453-4057qib7 15908 7 included include VBN cord-005453-4057qib7 15908 8 and and CC cord-005453-4057qib7 15908 9 followed follow VBN cord-005453-4057qib7 15908 10 until until IN cord-005453-4057qib7 15908 11 2016.Results 2016.results CD cord-005453-4057qib7 15908 12 : : : cord-005453-4057qib7 15909 1 An an DT cord-005453-4057qib7 15909 2 adequate adequate JJ cord-005453-4057qib7 15909 3 stem stem NN cord-005453-4057qib7 15909 4 cell cell NN cord-005453-4057qib7 15909 5 graft graft NN cord-005453-4057qib7 15909 6 was be VBD cord-005453-4057qib7 15909 7 defined define VBN cord-005453-4057qib7 15909 8 as as IN cord-005453-4057qib7 15909 9 ≥2.0 ≥2.0 NNP cord-005453-4057qib7 15909 10 x10Exp6 x10exp6 JJ cord-005453-4057qib7 15909 11 CD34 CD34 NNP cord-005453-4057qib7 15909 12 + + CC cord-005453-4057qib7 15909 13 cells cell NNS cord-005453-4057qib7 15909 14 /kg /kg NFP cord-005453-4057qib7 15909 15 body body NN cord-005453-4057qib7 15909 16 weight weight NN cord-005453-4057qib7 15909 17 . . . cord-005453-4057qib7 15910 1 97 97 CD cord-005453-4057qib7 15910 2 % % NN cord-005453-4057qib7 15910 3 of of IN cord-005453-4057qib7 15910 4 the the DT cord-005453-4057qib7 15910 5 patients patient NNS cord-005453-4057qib7 15910 6 were be VBD cord-005453-4057qib7 15910 7 able able JJ cord-005453-4057qib7 15910 8 to to TO cord-005453-4057qib7 15910 9 collect collect VB cord-005453-4057qib7 15910 10 at at IN cord-005453-4057qib7 15910 11 least least RBS cord-005453-4057qib7 15910 12 one one CD cord-005453-4057qib7 15910 13 stem stem NN cord-005453-4057qib7 15910 14 cell cell NN cord-005453-4057qib7 15910 15 graft graft NN cord-005453-4057qib7 15910 16 and and CC cord-005453-4057qib7 15910 17 the the DT cord-005453-4057qib7 15910 18 median median JJ cord-005453-4057qib7 15910 19 number number NN cord-005453-4057qib7 15910 20 of of IN cord-005453-4057qib7 15910 21 grafts graft NNS cord-005453-4057qib7 15910 22 per per IN cord-005453-4057qib7 15910 23 patient patient NN cord-005453-4057qib7 15910 24 was be VBD cord-005453-4057qib7 15910 25 1 1 CD cord-005453-4057qib7 15910 26 ( ( -LRB- cord-005453-4057qib7 15910 27 range range VB cord-005453-4057qib7 15910 28 0 0 CD cord-005453-4057qib7 15910 29 - - SYM cord-005453-4057qib7 15910 30 5 5 CD cord-005453-4057qib7 15910 31 ) ) -RRB- cord-005453-4057qib7 15910 32 . . . cord-005453-4057qib7 15911 1 We -PRON- PRP cord-005453-4057qib7 15911 2 could could MD cord-005453-4057qib7 15911 3 demonstrate demonstrate VB cord-005453-4057qib7 15911 4 that that IN cord-005453-4057qib7 15911 5 only only RB cord-005453-4057qib7 15911 6 31 31 CD cord-005453-4057qib7 15911 7 % % NN cord-005453-4057qib7 15911 8 of of IN cord-005453-4057qib7 15911 9 all all DT cord-005453-4057qib7 15911 10 patients patient NNS cord-005453-4057qib7 15911 11 who who WP cord-005453-4057qib7 15911 12 had have VBD cord-005453-4057qib7 15911 13 collected collect VBN cord-005453-4057qib7 15911 14 sufficient sufficient JJ cord-005453-4057qib7 15911 15 PBSCs pbsc NNS cord-005453-4057qib7 15911 16 for for IN cord-005453-4057qib7 15911 17 transplant transplant NN cord-005453-4057qib7 15911 18 subsequently subsequently RB cord-005453-4057qib7 15911 19 underwent undergo VBD cord-005453-4057qib7 15911 20 an an DT cord-005453-4057qib7 15911 21 ABSCT absct NN cord-005453-4057qib7 15911 22 . . . cord-005453-4057qib7 15912 1 Among among IN cord-005453-4057qib7 15912 2 the the DT cord-005453-4057qib7 15912 3 disease disease NN cord-005453-4057qib7 15912 4 entities entitie VBZ cord-005453-4057qib7 15912 5 the the DT cord-005453-4057qib7 15912 6 actual actual JJ cord-005453-4057qib7 15912 7 use use NN cord-005453-4057qib7 15912 8 of of IN cord-005453-4057qib7 15912 9 the the DT cord-005453-4057qib7 15912 10 stored store VBN cord-005453-4057qib7 15912 11 PBSC PBSC NNP cord-005453-4057qib7 15912 12 grafts graft NNS cord-005453-4057qib7 15912 13 varied vary VBN cord-005453-4057qib7 15912 14 considerably considerably RB cord-005453-4057qib7 15912 15 from from IN cord-005453-4057qib7 15912 16 0 0 CD cord-005453-4057qib7 15912 17 % % NN cord-005453-4057qib7 15912 18 to to TO cord-005453-4057qib7 15912 19 56 56 CD cord-005453-4057qib7 15912 20 % % NN cord-005453-4057qib7 15912 21 ( ( -LRB- cord-005453-4057qib7 15912 22 Figure figure NN cord-005453-4057qib7 15912 23 1 1 CD cord-005453-4057qib7 15912 24 ) ) -RRB- cord-005453-4057qib7 15912 25 .Conclusions .Conclusions . cord-005453-4057qib7 15913 1 : : : cord-005453-4057qib7 15913 2 We -PRON- PRP cord-005453-4057qib7 15913 3 could could MD cord-005453-4057qib7 15913 4 identify identify VB cord-005453-4057qib7 15913 5 striking strike VBG cord-005453-4057qib7 15913 6 discrepancies discrepancy NNS cord-005453-4057qib7 15913 7 between between IN cord-005453-4057qib7 15913 8 the the DT cord-005453-4057qib7 15913 9 collection collection NN cord-005453-4057qib7 15913 10 / / SYM cord-005453-4057qib7 15913 11 storage storage NN cord-005453-4057qib7 15913 12 and and CC cord-005453-4057qib7 15913 13 actual actual JJ cord-005453-4057qib7 15913 14 utilization utilization NN cord-005453-4057qib7 15913 15 of of IN cord-005453-4057qib7 15913 16 Background background NN cord-005453-4057qib7 15913 17 : : : cord-005453-4057qib7 15913 18 Biosimilars Biosimilars NNP cord-005453-4057qib7 15913 19 ( ( -LRB- cord-005453-4057qib7 15913 20 BIO BIO NNP cord-005453-4057qib7 15913 21 ) ) -RRB- cord-005453-4057qib7 15913 22 of of IN cord-005453-4057qib7 15913 23 granulocyte granulocyte NN cord-005453-4057qib7 15913 24 colony colony NN cord-005453-4057qib7 15913 25 stimulating stimulate VBG cord-005453-4057qib7 15913 26 factors factor NNS cord-005453-4057qib7 15913 27 ( ( -LRB- cord-005453-4057qib7 15913 28 GCSF GCSF NNP cord-005453-4057qib7 15913 29 ) ) -RRB- cord-005453-4057qib7 15913 30 were be VBD cord-005453-4057qib7 15913 31 approved approve VBN cord-005453-4057qib7 15913 32 several several JJ cord-005453-4057qib7 15913 33 years year NNS cord-005453-4057qib7 15913 34 ago ago RB cord-005453-4057qib7 15913 35 on on IN cord-005453-4057qib7 15913 36 the the DT cord-005453-4057qib7 15913 37 basis basis NN cord-005453-4057qib7 15913 38 of of IN cord-005453-4057qib7 15913 39 some some DT cord-005453-4057qib7 15913 40 studies study NNS cord-005453-4057qib7 15913 41 that that WDT cord-005453-4057qib7 15913 42 indicated indicate VBD cord-005453-4057qib7 15913 43 similar similar JJ cord-005453-4057qib7 15913 44 efficacy efficacy NN cord-005453-4057qib7 15913 45 to to IN cord-005453-4057qib7 15913 46 the the DT cord-005453-4057qib7 15913 47 already already RB cord-005453-4057qib7 15913 48 patented patent VBN cord-005453-4057qib7 15913 49 GCSF GCSF NNP cord-005453-4057qib7 15914 1 ( ( -LRB- cord-005453-4057qib7 15914 2 Neupogen Neupogen NNP cord-005453-4057qib7 15914 3 ® ® NNP cord-005453-4057qib7 15914 4 , , , cord-005453-4057qib7 15914 5 NEU NEU NNP cord-005453-4057qib7 15914 6 ) ) -RRB- cord-005453-4057qib7 15915 1 both both DT cord-005453-4057qib7 15915 2 in in IN cord-005453-4057qib7 15915 3 terms term NNS cord-005453-4057qib7 15915 4 of of IN cord-005453-4057qib7 15915 5 shortening shorten VBG cord-005453-4057qib7 15915 6 the the DT cord-005453-4057qib7 15915 7 neutropenic neutropenic JJ cord-005453-4057qib7 15915 8 period period NN cord-005453-4057qib7 15915 9 after after IN cord-005453-4057qib7 15915 10 chemotherapy chemotherapy NN cord-005453-4057qib7 15915 11 as as RB cord-005453-4057qib7 15915 12 well well RB cord-005453-4057qib7 15915 13 as as IN cord-005453-4057qib7 15915 14 peripheral peripheral JJ cord-005453-4057qib7 15915 15 blood blood NN cord-005453-4057qib7 15915 16 stem stem NN cord-005453-4057qib7 15915 17 cell cell NN cord-005453-4057qib7 15915 18 mobilization mobilization NN cord-005453-4057qib7 15915 19 in in IN cord-005453-4057qib7 15915 20 patients patient NNS cord-005453-4057qib7 15915 21 with with IN cord-005453-4057qib7 15915 22 lymphoma lymphoma NN cord-005453-4057qib7 15915 23 and and CC cord-005453-4057qib7 15915 24 multiple multiple JJ cord-005453-4057qib7 15915 25 myeloma myeloma NN cord-005453-4057qib7 15915 26 ( ( -LRB- cord-005453-4057qib7 15915 27 MM MM NNP cord-005453-4057qib7 15915 28 ) ) -RRB- cord-005453-4057qib7 15915 29 treated treat VBN cord-005453-4057qib7 15915 30 with with IN cord-005453-4057qib7 15915 31 autologous autologous JJ cord-005453-4057qib7 15915 32 stem stem NN cord-005453-4057qib7 15915 33 cell cell NN cord-005453-4057qib7 15915 34 transplantation transplantation NN cord-005453-4057qib7 15915 35 ( ( -LRB- cord-005453-4057qib7 15915 36 auto auto NN cord-005453-4057qib7 15915 37 - - HYPH cord-005453-4057qib7 15915 38 HCT HCT NNP cord-005453-4057qib7 15915 39 ) ) -RRB- cord-005453-4057qib7 15915 40 . . . cord-005453-4057qib7 15916 1 However however RB cord-005453-4057qib7 15916 2 , , , cord-005453-4057qib7 15916 3 all all PDT cord-005453-4057qib7 15916 4 these these DT cord-005453-4057qib7 15916 5 studies study NNS cord-005453-4057qib7 15916 6 are be VBP cord-005453-4057qib7 15916 7 retrospective retrospective JJ cord-005453-4057qib7 15916 8 and and CC cord-005453-4057qib7 15916 9 there there EX cord-005453-4057qib7 15916 10 are be VBP cord-005453-4057qib7 15916 11 still still RB cord-005453-4057qib7 15916 12 concerns concern NNS cord-005453-4057qib7 15916 13 about about IN cord-005453-4057qib7 15916 14 the the DT cord-005453-4057qib7 15916 15 real real JJ cord-005453-4057qib7 15916 16 efficacy efficacy NN cord-005453-4057qib7 15916 17 of of IN cord-005453-4057qib7 15916 18 BIO BIO NNP cord-005453-4057qib7 15916 19 and and CC cord-005453-4057qib7 15916 20 even even RB cord-005453-4057qib7 15916 21 more more JJR cord-005453-4057qib7 15916 22 about about IN cord-005453-4057qib7 15916 23 the the DT cord-005453-4057qib7 15916 24 real real JJ cord-005453-4057qib7 15916 25 benefit benefit NN cord-005453-4057qib7 15916 26 on on IN cord-005453-4057qib7 15916 27 final final JJ cord-005453-4057qib7 15916 28 costs cost NNS cord-005453-4057qib7 15916 29 . . . cord-005453-4057qib7 15917 1 Methods method NNS cord-005453-4057qib7 15917 2 : : : cord-005453-4057qib7 15917 3 We -PRON- PRP cord-005453-4057qib7 15917 4 have have VBP cord-005453-4057qib7 15917 5 retrospectively retrospectively RB cord-005453-4057qib7 15917 6 compared compare VBN cord-005453-4057qib7 15917 7 the the DT cord-005453-4057qib7 15917 8 characteristics characteristic NNS cord-005453-4057qib7 15917 9 of of IN cord-005453-4057qib7 15917 10 the the DT cord-005453-4057qib7 15917 11 mobilization mobilization NN cord-005453-4057qib7 15917 12 procedure procedure NN cord-005453-4057qib7 15917 13 in in IN cord-005453-4057qib7 15917 14 both both DT cord-005453-4057qib7 15917 15 patients patient NNS cord-005453-4057qib7 15917 16 with with IN cord-005453-4057qib7 15917 17 MM MM NNP cord-005453-4057qib7 15917 18 and and CC cord-005453-4057qib7 15917 19 lymphomas lymphoma NNS cord-005453-4057qib7 15917 20 , , , cord-005453-4057qib7 15917 21 and and CC cord-005453-4057qib7 15917 22 healthy healthy JJ cord-005453-4057qib7 15917 23 donors donor NNS cord-005453-4057qib7 15917 24 that that WDT cord-005453-4057qib7 15917 25 received receive VBD cord-005453-4057qib7 15917 26 either either CC cord-005453-4057qib7 15917 27 NEU NEU NNP cord-005453-4057qib7 15917 28 or or CC cord-005453-4057qib7 15917 29 BIO BIO NNP cord-005453-4057qib7 15917 30 ( ( -LRB- cord-005453-4057qib7 15917 31 with with IN cord-005453-4057qib7 15917 32 no no DT cord-005453-4057qib7 15917 33 chemotherapy chemotherapy NN cord-005453-4057qib7 15917 34 ) ) -RRB- cord-005453-4057qib7 15917 35 in in IN cord-005453-4057qib7 15917 36 4 4 CD cord-005453-4057qib7 15917 37 University University NNP cord-005453-4057qib7 15917 38 Hospitals Hospitals NNPS cord-005453-4057qib7 15917 39 in in IN cord-005453-4057qib7 15917 40 Catalunya Catalunya NNP cord-005453-4057qib7 15917 41 from from IN cord-005453-4057qib7 15917 42 December December NNP cord-005453-4057qib7 15917 43 / / SYM cord-005453-4057qib7 15917 44 2013 2013 CD cord-005453-4057qib7 15917 45 to to IN cord-005453-4057qib7 15917 46 November November NNP cord-005453-4057qib7 15917 47 2017 2017 CD cord-005453-4057qib7 15917 48 . . . cord-005453-4057qib7 15918 1 BIO BIO NNP cord-005453-4057qib7 15918 2 replaced replace VBD cord-005453-4057qib7 15918 3 NEU NEU NNP cord-005453-4057qib7 15918 4 in in IN cord-005453-4057qib7 15918 5 June June NNP cord-005453-4057qib7 15918 6 2016 2016 CD cord-005453-4057qib7 15918 7 in in IN cord-005453-4057qib7 15918 8 all all DT cord-005453-4057qib7 15918 9 4 4 CD cord-005453-4057qib7 15918 10 institutions institution NNS cord-005453-4057qib7 15918 11 . . . cord-005453-4057qib7 15919 1 Primary primary JJ cord-005453-4057qib7 15919 2 objectives objective NNS cord-005453-4057qib7 15919 3 were be VBD cord-005453-4057qib7 15919 4 the the DT cord-005453-4057qib7 15919 5 mobilization mobilization NN cord-005453-4057qib7 15919 6 rate rate NN cord-005453-4057qib7 15919 7 ( ( -LRB- cord-005453-4057qib7 15919 8 defined define VBN cord-005453-4057qib7 15919 9 as as IN cord-005453-4057qib7 15919 10 the the DT cord-005453-4057qib7 15919 11 percentage percentage NN cord-005453-4057qib7 15919 12 of of IN cord-005453-4057qib7 15919 13 patients patient NNS cord-005453-4057qib7 15919 14 that that WDT cord-005453-4057qib7 15919 15 achieved achieve VBD cord-005453-4057qib7 15919 16 ≥ ≥ CD cord-005453-4057qib7 15919 17 10 10 CD cord-005453-4057qib7 15920 1 x x SYM cord-005453-4057qib7 15920 2 10 10 CD cord-005453-4057qib7 15920 3 3 3 CD cord-005453-4057qib7 15921 1 /ml /ml . cord-005453-4057qib7 15922 1 CD34 CD34 NNP cord-005453-4057qib7 15922 2 + + CC cord-005453-4057qib7 15922 3 cells cell NNS cord-005453-4057qib7 15922 4 in in IN cord-005453-4057qib7 15922 5 peripheral peripheral JJ cord-005453-4057qib7 15922 6 blood blood NN cord-005453-4057qib7 15922 7 on on IN cord-005453-4057qib7 15922 8 day day NN cord-005453-4057qib7 15922 9 4 4 CD cord-005453-4057qib7 15922 10 ) ) -RRB- cord-005453-4057qib7 15922 11 and and CC cord-005453-4057qib7 15922 12 the the DT cord-005453-4057qib7 15922 13 use use NN cord-005453-4057qib7 15922 14 of of IN cord-005453-4057qib7 15922 15 plerixafor plerixafor NN cord-005453-4057qib7 15922 16 ( ( -LRB- cord-005453-4057qib7 15922 17 PLEX PLEX NNP cord-005453-4057qib7 15922 18 ) ) -RRB- cord-005453-4057qib7 15922 19 in in IN cord-005453-4057qib7 15922 20 each each DT cord-005453-4057qib7 15922 21 group group NN cord-005453-4057qib7 15922 22 as as IN cord-005453-4057qib7 15922 23 pre pre JJ cord-005453-4057qib7 15922 24 - - JJ cord-005453-4057qib7 15922 25 emptive emptive JJ cord-005453-4057qib7 15922 26 strategy strategy NN cord-005453-4057qib7 15922 27 . . . cord-005453-4057qib7 15923 1 A a DT cord-005453-4057qib7 15923 2 multivariable multivariable JJ cord-005453-4057qib7 15923 3 analysis analysis NN cord-005453-4057qib7 15923 4 of of IN cord-005453-4057qib7 15923 5 risk risk NN cord-005453-4057qib7 15923 6 factors factor NNS cord-005453-4057qib7 15923 7 influencing influence VBG cord-005453-4057qib7 15923 8 the the DT cord-005453-4057qib7 15923 9 use use NN cord-005453-4057qib7 15923 10 of of IN cord-005453-4057qib7 15923 11 PLEX PLEX NNP cord-005453-4057qib7 15923 12 and and CC cord-005453-4057qib7 15923 13 mobilization mobilization NN cord-005453-4057qib7 15923 14 failure failure NN cord-005453-4057qib7 15923 15 ( ( -LRB- cord-005453-4057qib7 15923 16 defined define VBN cord-005453-4057qib7 15923 17 as as IN cord-005453-4057qib7 15923 18 collection collection NN cord-005453-4057qib7 15923 19 of of IN cord-005453-4057qib7 15923 20 < < NNP cord-005453-4057qib7 15923 21 2 2 CD cord-005453-4057qib7 15923 22 x x SYM cord-005453-4057qib7 15923 23 10 10 CD cord-005453-4057qib7 15923 24 6 6 CD cord-005453-4057qib7 15924 1 /kg /kg . cord-005453-4057qib7 15925 1 CD34 CD34 NNP cord-005453-4057qib7 15925 2 + + CC cord-005453-4057qib7 15925 3 cells cell NNS cord-005453-4057qib7 15925 4 ) ) -RRB- cord-005453-4057qib7 15925 5 was be VBD cord-005453-4057qib7 15925 6 also also RB cord-005453-4057qib7 15925 7 performed perform VBN cord-005453-4057qib7 15925 8 . . . cord-005453-4057qib7 15926 1 Results result NNS cord-005453-4057qib7 15926 2 : : : cord-005453-4057qib7 15927 1 We -PRON- PRP cord-005453-4057qib7 15927 2 treated treat VBD cord-005453-4057qib7 15927 3 216 216 CD cord-005453-4057qib7 15927 4 patients patient NNS cord-005453-4057qib7 15927 5 ( ( -LRB- cord-005453-4057qib7 15927 6 102 102 CD cord-005453-4057qib7 15927 7 lymphomas lymphoma NNS cord-005453-4057qib7 15927 8 and and CC cord-005453-4057qib7 15927 9 114 114 CD cord-005453-4057qib7 15927 10 MM MM NNP cord-005453-4057qib7 15927 11 ) ) -RRB- cord-005453-4057qib7 15927 12 and and CC cord-005453-4057qib7 15927 13 55 55 CD cord-005453-4057qib7 15927 14 healthy healthy JJ cord-005453-4057qib7 15927 15 donors donor NNS cord-005453-4057qib7 15927 16 . . . cord-005453-4057qib7 15928 1 Both both DT cord-005453-4057qib7 15928 2 groups group NNS cord-005453-4057qib7 15928 3 of of IN cord-005453-4057qib7 15928 4 patients patient NNS cord-005453-4057qib7 15928 5 ( ( -LRB- cord-005453-4057qib7 15928 6 138 138 CD cord-005453-4057qib7 15928 7 NEU NEU NNP cord-005453-4057qib7 15928 8 and and CC cord-005453-4057qib7 15928 9 78 78 CD cord-005453-4057qib7 15928 10 BIO BIO NNP cord-005453-4057qib7 15928 11 ) ) -RRB- cord-005453-4057qib7 15928 12 and and CC cord-005453-4057qib7 15928 13 donors donor NNS cord-005453-4057qib7 15928 14 ( ( -LRB- cord-005453-4057qib7 15928 15 33 33 CD cord-005453-4057qib7 15928 16 NEU NEU NNP cord-005453-4057qib7 15928 17 and and CC cord-005453-4057qib7 15928 18 22 22 CD cord-005453-4057qib7 15928 19 BIO BIO NNP cord-005453-4057qib7 15928 20 ) ) -RRB- cord-005453-4057qib7 15928 21 were be VBD cord-005453-4057qib7 15928 22 comparable comparable JJ cord-005453-4057qib7 15928 23 regarding regard VBG cord-005453-4057qib7 15928 24 pre pre JJ cord-005453-4057qib7 15928 25 - - JJ cord-005453-4057qib7 15928 26 mobilization mobilization JJ cord-005453-4057qib7 15928 27 general general JJ cord-005453-4057qib7 15928 28 characteristics characteristic NNS cord-005453-4057qib7 15928 29 . . . cord-005453-4057qib7 15929 1 There there EX cord-005453-4057qib7 15929 2 was be VBD cord-005453-4057qib7 15929 3 a a DT cord-005453-4057qib7 15929 4 trend trend NN cord-005453-4057qib7 15929 5 for for IN cord-005453-4057qib7 15929 6 a a DT cord-005453-4057qib7 15929 7 lower low JJR cord-005453-4057qib7 15929 8 median median JJ cord-005453-4057qib7 15929 9 CD34 CD34 NNP cord-005453-4057qib7 15929 10 + + CC cord-005453-4057qib7 15929 11 peak peak NN cord-005453-4057qib7 15929 12 on on IN cord-005453-4057qib7 15929 13 day day NN cord-005453-4057qib7 15929 14 4 4 CD cord-005453-4057qib7 15929 15 for for IN cord-005453-4057qib7 15929 16 BIO BIO NNP cord-005453-4057qib7 15929 17 patients patient NNS cord-005453-4057qib7 15929 18 ( ( -LRB- cord-005453-4057qib7 15929 19 17 17 CD cord-005453-4057qib7 15929 20 vs vs IN cord-005453-4057qib7 15929 21 20 20 CD cord-005453-4057qib7 15929 22 , , , cord-005453-4057qib7 15929 23 p p NN cord-005453-4057qib7 15929 24 value value NN cord-005453-4057qib7 15929 25 = = SYM cord-005453-4057qib7 15929 26 0.1 0.1 CD cord-005453-4057qib7 15929 27 ) ) -RRB- cord-005453-4057qib7 15929 28 . . . cord-005453-4057qib7 15930 1 A a DT cord-005453-4057qib7 15930 2 total total NN cord-005453-4057qib7 15930 3 of of IN cord-005453-4057qib7 15930 4 53 53 CD cord-005453-4057qib7 15930 5 patients patient NNS cord-005453-4057qib7 15930 6 received receive VBD cord-005453-4057qib7 15930 7 PLEX PLEX NNP cord-005453-4057qib7 15930 8 , , , cord-005453-4057qib7 15930 9 although although IN cord-005453-4057qib7 15930 10 7 7 CD cord-005453-4057qib7 15930 11 of of IN cord-005453-4057qib7 15930 12 them -PRON- PRP cord-005453-4057qib7 15930 13 ( ( -LRB- cord-005453-4057qib7 15930 14 13.2 13.2 CD cord-005453-4057qib7 15930 15 % % NN cord-005453-4057qib7 15930 16 ) ) -RRB- cord-005453-4057qib7 15930 17 out out IN cord-005453-4057qib7 15930 18 of of IN cord-005453-4057qib7 15930 19 strict strict JJ cord-005453-4057qib7 15930 20 theoretical theoretical JJ cord-005453-4057qib7 15930 21 indication indication NN cord-005453-4057qib7 15930 22 , , , cord-005453-4057qib7 15930 23 CD34 CD34 NNP cord-005453-4057qib7 15930 24 + + CC cord-005453-4057qib7 15930 25 cells cell NNS cord-005453-4057qib7 15930 26 > > XX cord-005453-4057qib7 15931 1 10 10 CD cord-005453-4057qib7 15931 2 x x SYM cord-005453-4057qib7 15931 3 10 10 CD cord-005453-4057qib7 15931 4 3 3 CD cord-005453-4057qib7 15932 1 /ml /ml . cord-005453-4057qib7 15933 1 ( ( -LRB- cord-005453-4057qib7 15933 2 range range NNP cord-005453-4057qib7 15933 3 10.5 10.5 CD cord-005453-4057qib7 15933 4 - - HYPH cord-005453-4057qib7 15933 5 13.5 13.5 CD cord-005453-4057qib7 15933 6 ) ) -RRB- cord-005453-4057qib7 15933 7 and and CC cord-005453-4057qib7 15933 8 were be VBD cord-005453-4057qib7 15933 9 removed remove VBN cord-005453-4057qib7 15933 10 for for IN cord-005453-4057qib7 15933 11 further further JJ cord-005453-4057qib7 15933 12 analysis analysis NN cord-005453-4057qib7 15933 13 ( ( -LRB- cord-005453-4057qib7 15933 14 n n NN cord-005453-4057qib7 15933 15 = = SYM cord-005453-4057qib7 15933 16 46 46 CD cord-005453-4057qib7 15933 17 , , , cord-005453-4057qib7 15933 18 31 31 CD cord-005453-4057qib7 15933 19 in in IN cord-005453-4057qib7 15933 20 the the DT cord-005453-4057qib7 15933 21 NEU NEU NNP cord-005453-4057qib7 15933 22 group group NN cord-005453-4057qib7 15933 23 and and CC cord-005453-4057qib7 15933 24 15 15 CD cord-005453-4057qib7 15933 25 in in IN cord-005453-4057qib7 15933 26 the the DT cord-005453-4057qib7 15933 27 BIO BIO NNP cord-005453-4057qib7 15933 28 group group NN cord-005453-4057qib7 15933 29 ) ) -RRB- cord-005453-4057qib7 15933 30 . . . cord-005453-4057qib7 15934 1 Median median JJ cord-005453-4057qib7 15934 2 number number NN cord-005453-4057qib7 15934 3 of of IN cord-005453-4057qib7 15934 4 CD34 CD34 NNP cord-005453-4057qib7 15934 5 + + CC cord-005453-4057qib7 15934 6 cells cell NNS cord-005453-4057qib7 15934 7 on on IN cord-005453-4057qib7 15934 8 day day NN cord-005453-4057qib7 15934 9 4 4 CD cord-005453-4057qib7 15934 10 was be VBD cord-005453-4057qib7 15934 11 significantly significantly RB cord-005453-4057qib7 15934 12 lower low JJR cord-005453-4057qib7 15934 13 in in IN cord-005453-4057qib7 15934 14 the the DT cord-005453-4057qib7 15934 15 group group NN cord-005453-4057qib7 15934 16 BIO BIO NNP cord-005453-4057qib7 15934 17 who who WP cord-005453-4057qib7 15934 18 needed need VBD cord-005453-4057qib7 15934 19 PLEX PLEX NNP cord-005453-4057qib7 15934 20 ( ( -LRB- cord-005453-4057qib7 15934 21 2.4 2.4 CD cord-005453-4057qib7 15934 22 vs vs IN cord-005453-4057qib7 15934 23 4.8 4.8 CD cord-005453-4057qib7 15934 24 for for IN cord-005453-4057qib7 15934 25 NEU+PLEX neu+plex NN cord-005453-4057qib7 15934 26 , , , cord-005453-4057qib7 15934 27 p=002 p=002 NNP cord-005453-4057qib7 15934 28 ) ) -RRB- cord-005453-4057qib7 15934 29 , , , cord-005453-4057qib7 15934 30 as as RB cord-005453-4057qib7 15934 31 well well RB cord-005453-4057qib7 15934 32 as as IN cord-005453-4057qib7 15934 33 CD34 CD34 NNP cord-005453-4057qib7 15934 34 + + CC cord-005453-4057qib7 15934 35 cells cell NNS cord-005453-4057qib7 15934 36 finally finally RB cord-005453-4057qib7 15934 37 harvested harvest VBN cord-005453-4057qib7 15934 38 ( ( -LRB- cord-005453-4057qib7 15934 39 2.5 2.5 CD cord-005453-4057qib7 15934 40 vs vs IN cord-005453-4057qib7 15934 41 3.3x 3.3x CD cord-005453-4057qib7 15934 42 10 10 CD cord-005453-4057qib7 15934 43 6 6 CD cord-005453-4057qib7 15934 44 /kg /kg CD cord-005453-4057qib7 15934 45 , , , cord-005453-4057qib7 15934 46 p=0.03 p=0.03 NNP cord-005453-4057qib7 15934 47 ) ) -RRB- cord-005453-4057qib7 15934 48 . . . cord-005453-4057qib7 15935 1 Mobilization mobilization NN cord-005453-4057qib7 15935 2 failure failure NN cord-005453-4057qib7 15935 3 rate rate NN cord-005453-4057qib7 15935 4 was be VBD cord-005453-4057qib7 15935 5 higher high JJR cord-005453-4057qib7 15935 6 in in IN cord-005453-4057qib7 15935 7 BIO BIO NNP cord-005453-4057qib7 15935 8 group group NN cord-005453-4057qib7 15935 9 ( ( -LRB- cord-005453-4057qib7 15935 10 0 0 CD cord-005453-4057qib7 15935 11 vs vs IN cord-005453-4057qib7 15935 12 20 20 CD cord-005453-4057qib7 15935 13 % % NN cord-005453-4057qib7 15935 14 , , , cord-005453-4057qib7 15935 15 p=0.01 p=0.01 NNP cord-005453-4057qib7 15935 16 ) ) -RRB- cord-005453-4057qib7 15935 17 . . . cord-005453-4057qib7 15936 1 Regarding regard VBG cord-005453-4057qib7 15936 2 no no DT cord-005453-4057qib7 15936 3 PLEX PLEX NNP cord-005453-4057qib7 15936 4 patients patient NNS cord-005453-4057qib7 15936 5 , , , cord-005453-4057qib7 15936 6 median median JJ cord-005453-4057qib7 15936 7 number number NN cord-005453-4057qib7 15936 8 of of IN cord-005453-4057qib7 15936 9 CD34 CD34 NNP cord-005453-4057qib7 15936 10 + + CC cord-005453-4057qib7 15936 11 cells cell NNS cord-005453-4057qib7 15936 12 on on IN cord-005453-4057qib7 15936 13 day day NN cord-005453-4057qib7 15936 14 4 4 CD cord-005453-4057qib7 15936 15 was be VBD cord-005453-4057qib7 15936 16 also also RB cord-005453-4057qib7 15936 17 significantly significantly RB cord-005453-4057qib7 15936 18 lower low JJR cord-005453-4057qib7 15936 19 for for IN cord-005453-4057qib7 15936 20 BIO BIO NNP cord-005453-4057qib7 15936 21 patients patient NNS cord-005453-4057qib7 15936 22 ( ( -LRB- cord-005453-4057qib7 15936 23 33.4 33.4 CD cord-005453-4057qib7 15936 24 vs vs IN cord-005453-4057qib7 15936 25 23.7 23.7 CD cord-005453-4057qib7 15936 26 , , , cord-005453-4057qib7 15936 27 p=0.03 p=0.03 NNP cord-005453-4057qib7 15936 28 ) ) -RRB- cord-005453-4057qib7 15936 29 . . . cord-005453-4057qib7 15937 1 Risk risk NN cord-005453-4057qib7 15937 2 factors factor NNS cord-005453-4057qib7 15937 3 for for IN cord-005453-4057qib7 15937 4 PLEX PLEX NNP cord-005453-4057qib7 15937 5 use use NN cord-005453-4057qib7 15937 6 were be VBD cord-005453-4057qib7 15937 7 age age NN cord-005453-4057qib7 15937 8 , , , cord-005453-4057qib7 15937 9 basal basal NN cord-005453-4057qib7 15937 10 disease disease NN cord-005453-4057qib7 15937 11 ( ( -LRB- cord-005453-4057qib7 15937 12 lymphoma lymphoma NN cord-005453-4057qib7 15937 13 ) ) -RRB- cord-005453-4057qib7 15937 14 and and CC cord-005453-4057qib7 15937 15 number number NN cord-005453-4057qib7 15937 16 of of IN cord-005453-4057qib7 15937 17 prior prior JJ cord-005453-4057qib7 15937 18 mobilization mobilization NN cord-005453-4057qib7 15937 19 therapies therapy NNS cord-005453-4057qib7 15937 20 . . . cord-005453-4057qib7 15938 1 The the DT cord-005453-4057qib7 15938 2 use use NN cord-005453-4057qib7 15938 3 of of IN cord-005453-4057qib7 15938 4 BIO BIO NNP cord-005453-4057qib7 15938 5 was be VBD cord-005453-4057qib7 15938 6 the the DT cord-005453-4057qib7 15938 7 only only JJ cord-005453-4057qib7 15938 8 risk risk NN cord-005453-4057qib7 15938 9 factor factor NN cord-005453-4057qib7 15938 10 for for IN cord-005453-4057qib7 15938 11 mobilization mobilization NN cord-005453-4057qib7 15938 12 failure failure NN cord-005453-4057qib7 15938 13 patients patient NNS cord-005453-4057qib7 15938 14 receiving receive VBG cord-005453-4057qib7 15938 15 PLEX PLEX NNP cord-005453-4057qib7 15938 16 [ [ -LRB- cord-005453-4057qib7 15938 17 HR HR NNP cord-005453-4057qib7 15938 18 10.3 10.3 CD cord-005453-4057qib7 15938 19 ( ( -LRB- cord-005453-4057qib7 15938 20 95%CI 95%ci CD cord-005453-4057qib7 15938 21 1.3 1.3 CD cord-005453-4057qib7 15938 22 - - HYPH cord-005453-4057qib7 15938 23 77.8 77.8 CD cord-005453-4057qib7 15938 24 ) ) -RRB- cord-005453-4057qib7 15938 25 , , , cord-005453-4057qib7 15938 26 p=0.02 p=0.02 NNP cord-005453-4057qib7 15938 27 ] ] -RRB- cord-005453-4057qib7 15938 28 . . . cord-005453-4057qib7 15939 1 With with IN cord-005453-4057qib7 15939 2 respect respect NN cord-005453-4057qib7 15939 3 to to IN cord-005453-4057qib7 15939 4 healthy healthy JJ cord-005453-4057qib7 15939 5 donor donor NN cord-005453-4057qib7 15939 6 mobilization mobilization NN cord-005453-4057qib7 15939 7 , , , cord-005453-4057qib7 15939 8 none none NN cord-005453-4057qib7 15939 9 of of IN cord-005453-4057qib7 15939 10 them -PRON- PRP cord-005453-4057qib7 15939 11 needed need VBD cord-005453-4057qib7 15939 12 PLEX PLEX NNP cord-005453-4057qib7 15939 13 but but CC cord-005453-4057qib7 15939 14 2 2 CD cord-005453-4057qib7 15939 15 cases case NNS cord-005453-4057qib7 15939 16 from from IN cord-005453-4057qib7 15939 17 the the DT cord-005453-4057qib7 15939 18 BIO BIO NNP cord-005453-4057qib7 15939 19 group group NN cord-005453-4057qib7 15939 20 ( ( -LRB- cord-005453-4057qib7 15939 21 9 9 CD cord-005453-4057qib7 15939 22 % % NN cord-005453-4057qib7 15939 23 ) ) -RRB- cord-005453-4057qib7 15939 24 needed need VBD cord-005453-4057qib7 15939 25 more more JJR cord-005453-4057qib7 15939 26 than than IN cord-005453-4057qib7 15939 27 one one CD cord-005453-4057qib7 15939 28 apheresis apheresis NN cord-005453-4057qib7 15939 29 procedures procedure NNS cord-005453-4057qib7 15939 30 ( ( -LRB- cord-005453-4057qib7 15939 31 2 2 CD cord-005453-4057qib7 15939 32 and and CC cord-005453-4057qib7 15939 33 3 3 CD cord-005453-4057qib7 15939 34 , , , cord-005453-4057qib7 15939 35 respectively).Conclusions respectively).conclusion NNS cord-005453-4057qib7 15940 1 : : : cord-005453-4057qib7 15940 2 We -PRON- PRP cord-005453-4057qib7 15940 3 found find VBD cord-005453-4057qib7 15940 4 a a DT cord-005453-4057qib7 15940 5 lower low JJR cord-005453-4057qib7 15940 6 efficacy efficacy NN cord-005453-4057qib7 15940 7 of of IN cord-005453-4057qib7 15940 8 BIO BIO NNP cord-005453-4057qib7 15940 9 in in IN cord-005453-4057qib7 15940 10 the the DT cord-005453-4057qib7 15940 11 setting setting NN cord-005453-4057qib7 15940 12 of of IN cord-005453-4057qib7 15940 13 stem stem NN cord-005453-4057qib7 15940 14 cell cell NN cord-005453-4057qib7 15940 15 mobilization mobilization NN cord-005453-4057qib7 15940 16 of of IN cord-005453-4057qib7 15940 17 patients patient NNS cord-005453-4057qib7 15940 18 with with IN cord-005453-4057qib7 15940 19 only only JJ cord-005453-4057qib7 15940 20 GCSF GCSF NNP cord-005453-4057qib7 15940 21 both both CC cord-005453-4057qib7 15940 22 in in IN cord-005453-4057qib7 15940 23 terms term NNS cord-005453-4057qib7 15940 24 of of IN cord-005453-4057qib7 15940 25 a a DT cord-005453-4057qib7 15940 26 lower low JJR cord-005453-4057qib7 15940 27 CD34 CD34 NNP cord-005453-4057qib7 15940 28 + + CC cord-005453-4057qib7 15940 29 cells cell NNS cord-005453-4057qib7 15940 30 peak peak NN cord-005453-4057qib7 15940 31 on on IN cord-005453-4057qib7 15940 32 day day NN cord-005453-4057qib7 15940 33 4 4 CD cord-005453-4057qib7 15940 34 and and CC cord-005453-4057qib7 15940 35 a a DT cord-005453-4057qib7 15940 36 lower low JJR cord-005453-4057qib7 15940 37 number number NN cord-005453-4057qib7 15940 38 of of IN cord-005453-4057qib7 15940 39 CD34 CD34 NNP cord-005453-4057qib7 15940 40 + + CC cord-005453-4057qib7 15940 41 cells cell NNS cord-005453-4057qib7 15940 42 in in IN cord-005453-4057qib7 15940 43 final final JJ cord-005453-4057qib7 15940 44 apheresis apheresis NN cord-005453-4057qib7 15940 45 product product NN cord-005453-4057qib7 15940 46 . . . cord-005453-4057qib7 15941 1 BIO BIO NNP cord-005453-4057qib7 15941 2 GCSF GCSF NNP cord-005453-4057qib7 15941 3 also also RB cord-005453-4057qib7 15941 4 seems seem VBZ cord-005453-4057qib7 15941 5 to to TO cord-005453-4057qib7 15941 6 be be VB cord-005453-4057qib7 15941 7 less less RBR cord-005453-4057qib7 15941 8 effective effective JJ cord-005453-4057qib7 15941 9 in in IN cord-005453-4057qib7 15941 10 healthy healthy JJ cord-005453-4057qib7 15941 11 donors donor NNS cord-005453-4057qib7 15941 12 . . . cord-005453-4057qib7 15942 1 Disclosure disclosure NN cord-005453-4057qib7 15942 2 : : : cord-005453-4057qib7 15942 3 No no DT cord-005453-4057qib7 15942 4 conflict conflict NN cord-005453-4057qib7 15942 5 of of IN cord-005453-4057qib7 15942 6 interest interest NN cord-005453-4057qib7 15942 7 to to TO cord-005453-4057qib7 15942 8 be be VB cord-005453-4057qib7 15942 9 declaredBackground declaredBackground VBN cord-005453-4057qib7 15942 10 : : : cord-005453-4057qib7 15943 1 Auto Auto NNP cord-005453-4057qib7 15943 2 - - HYPH cord-005453-4057qib7 15943 3 SCT SCT NNP cord-005453-4057qib7 15943 4 is be VBZ cord-005453-4057qib7 15943 5 a a DT cord-005453-4057qib7 15943 6 common common JJ cord-005453-4057qib7 15943 7 treatment treatment NN cord-005453-4057qib7 15943 8 in in IN cord-005453-4057qib7 15943 9 patients patient NNS cord-005453-4057qib7 15943 10 with with IN cord-005453-4057qib7 15943 11 MM MM NNP cord-005453-4057qib7 15943 12 or or CC cord-005453-4057qib7 15943 13 NHL NHL NNP cord-005453-4057qib7 15943 14 . . . cord-005453-4057qib7 15944 1 The the DT cord-005453-4057qib7 15944 2 aim aim NN cord-005453-4057qib7 15944 3 of of IN cord-005453-4057qib7 15944 4 the the DT cord-005453-4057qib7 15944 5 prospective prospective JJ cord-005453-4057qib7 15944 6 multicenter multicenter NN cord-005453-4057qib7 15944 7 GOA GOA NNP cord-005453-4057qib7 15944 8 ( ( -LRB- cord-005453-4057qib7 15944 9 Graft graft NN cord-005453-4057qib7 15944 10 and and CC cord-005453-4057qib7 15944 11 Outcome outcome VB cord-005453-4057qib7 15944 12 in in IN cord-005453-4057qib7 15944 13 Autologous autologous JJ cord-005453-4057qib7 15944 14 transplantation transplantation NN cord-005453-4057qib7 15944 15 ) ) -RRB- cord-005453-4057qib7 15944 16 study study NN cord-005453-4057qib7 15944 17 was be VBD cord-005453-4057qib7 15944 18 to to TO cord-005453-4057qib7 15944 19 investigate investigate VB cord-005453-4057qib7 15944 20 the the DT cord-005453-4057qib7 15944 21 impact impact NN cord-005453-4057qib7 15944 22 of of IN cord-005453-4057qib7 15944 23 mobilization mobilization NN cord-005453-4057qib7 15944 24 method method NN cord-005453-4057qib7 15944 25 used use VBN cord-005453-4057qib7 15944 26 on on IN cord-005453-4057qib7 15944 27 the the DT cord-005453-4057qib7 15944 28 cellular cellular JJ cord-005453-4057qib7 15944 29 composition composition NN cord-005453-4057qib7 15944 30 of of IN cord-005453-4057qib7 15944 31 collected collect VBN cord-005453-4057qib7 15944 32 blood blood NN cord-005453-4057qib7 15944 33 grafts graft NNS cord-005453-4057qib7 15944 34 and and CC cord-005453-4057qib7 15944 35 eventually eventually RB cord-005453-4057qib7 15944 36 hematological hematological JJ cord-005453-4057qib7 15944 37 and and CC cord-005453-4057qib7 15944 38 immune immune JJ cord-005453-4057qib7 15944 39 recovery recovery NN cord-005453-4057qib7 15944 40 as as RB cord-005453-4057qib7 15944 41 well well RB cord-005453-4057qib7 15944 42 as as IN cord-005453-4057qib7 15944 43 long long JJ cord-005453-4057qib7 15944 44 - - HYPH cord-005453-4057qib7 15944 45 term term NN cord-005453-4057qib7 15944 46 outcome outcome NN cord-005453-4057qib7 15944 47 post post NN cord-005453-4057qib7 15944 48 - - NN cord-005453-4057qib7 15944 49 transplant transplant NN cord-005453-4057qib7 15944 50 . . . cord-005453-4057qib7 15945 1 Altogether altogether RB cord-005453-4057qib7 15945 2 282 282 CD cord-005453-4057qib7 15945 3 patients patient NNS cord-005453-4057qib7 15945 4 with with IN cord-005453-4057qib7 15945 5 MM MM NNP cord-005453-4057qib7 15945 6 or or CC cord-005453-4057qib7 15945 7 NHL NHL NNP cord-005453-4057qib7 15945 8 transplanted transplant VBN cord-005453-4057qib7 15945 9 between between IN cord-005453-4057qib7 15945 10 5/2012 5/2012 CD cord-005453-4057qib7 15945 11 and and CC cord-005453-4057qib7 15945 12 12/2016 12/2016 CD cord-005453-4057qib7 15945 13 at at IN cord-005453-4057qib7 15945 14 four four CD cord-005453-4057qib7 15945 15 university university NN cord-005453-4057qib7 15945 16 hospitals hospital NNS cord-005453-4057qib7 15945 17 were be VBD cord-005453-4057qib7 15945 18 included include VBN cord-005453-4057qib7 15945 19 . . . cord-005453-4057qib7 15946 1 The the DT cord-005453-4057qib7 15946 2 long long JJ cord-005453-4057qib7 15946 3 - - HYPH cord-005453-4057qib7 15946 4 term term NN cord-005453-4057qib7 15946 5 goal goal NN cord-005453-4057qib7 15946 6 of of IN cord-005453-4057qib7 15946 7 the the DT cord-005453-4057qib7 15946 8 study study NN cord-005453-4057qib7 15946 9 is be VBZ cord-005453-4057qib7 15946 10 to to TO cord-005453-4057qib7 15946 11 evaluate evaluate VB cord-005453-4057qib7 15946 12 characteristics characteristic NNS cord-005453-4057qib7 15946 13 of of IN cord-005453-4057qib7 15946 14 optimal optimal JJ cord-005453-4057qib7 15946 15 blood blood NN cord-005453-4057qib7 15946 16 grafts graft NNS cord-005453-4057qib7 15946 17 in in IN cord-005453-4057qib7 15946 18 regard regard NN cord-005453-4057qib7 15946 19 to to IN cord-005453-4057qib7 15946 20 post post JJ cord-005453-4057qib7 15946 21 - - JJ cord-005453-4057qib7 15946 22 transplant transplant JJ cord-005453-4057qib7 15946 23 recovery recovery NN cord-005453-4057qib7 15946 24 and and CC cord-005453-4057qib7 15946 25 outcome outcome NN cord-005453-4057qib7 15946 26 . . . cord-005453-4057qib7 15947 1 Methods method NNS cord-005453-4057qib7 15947 2 : : : cord-005453-4057qib7 15947 3 Altogether altogether RB cord-005453-4057qib7 15947 4 147 147 CD cord-005453-4057qib7 15947 5 patients patient NNS cord-005453-4057qib7 15947 6 with with IN cord-005453-4057qib7 15947 7 MM MM NNP cord-005453-4057qib7 15947 8 undergoing undergo VBG cord-005453-4057qib7 15947 9 first first JJ cord-005453-4057qib7 15947 10 auto auto NN cord-005453-4057qib7 15947 11 - - HYPH cord-005453-4057qib7 15947 12 SCT SCT NNP cord-005453-4057qib7 15947 13 were be VBD cord-005453-4057qib7 15947 14 compared compare VBN cord-005453-4057qib7 15947 15 with with IN cord-005453-4057qib7 15947 16 135 135 CD cord-005453-4057qib7 15947 17 patients patient NNS cord-005453-4057qib7 15947 18 with with IN cord-005453-4057qib7 15947 19 NHL NHL NNP cord-005453-4057qib7 15947 20 . . . cord-005453-4057qib7 15948 1 All all DT cord-005453-4057qib7 15948 2 NHL NHL NNP cord-005453-4057qib7 15948 3 patients patient NNS cord-005453-4057qib7 15948 4 were be VBD cord-005453-4057qib7 15948 5 mobilized mobilize VBN cord-005453-4057qib7 15948 6 with with IN cord-005453-4057qib7 15948 7 chemotherapy chemotherapy NN cord-005453-4057qib7 15948 8 + + CC cord-005453-4057qib7 15948 9 G G NNP cord-005453-4057qib7 15948 10 - - HYPH cord-005453-4057qib7 15948 11 CSF CSF NNP cord-005453-4057qib7 15948 12 , , , cord-005453-4057qib7 15948 13 whereas whereas IN cord-005453-4057qib7 15948 14 39 39 CD cord-005453-4057qib7 15948 15 % % NN cord-005453-4057qib7 15948 16 of of IN cord-005453-4057qib7 15948 17 MM MM NNP cord-005453-4057qib7 15948 18 patients patient NNS cord-005453-4057qib7 15948 19 were be VBD cord-005453-4057qib7 15948 20 mobilized mobilize VBN cord-005453-4057qib7 15948 21 with with IN cord-005453-4057qib7 15948 22 G G NNP cord-005453-4057qib7 15948 23 - - HYPH cord-005453-4057qib7 15948 24 CSF CSF NNP cord-005453-4057qib7 15948 25 only only RB cord-005453-4057qib7 15948 26 ( ( -LRB- cord-005453-4057qib7 15948 27 p p NN cord-005453-4057qib7 15948 28 < < XX cord-005453-4057qib7 15948 29 0.001 0.001 CD cord-005453-4057qib7 15948 30 ) ) -RRB- cord-005453-4057qib7 15948 31 . . . cord-005453-4057qib7 15949 1 Mobilization mobilization NN cord-005453-4057qib7 15949 2 data datum NNS cord-005453-4057qib7 15949 3 , , , cord-005453-4057qib7 15949 4 graft graft NN cord-005453-4057qib7 15949 5 cellular cellular JJ cord-005453-4057qib7 15949 6 composition composition NN cord-005453-4057qib7 15949 7 including include VBG cord-005453-4057qib7 15949 8 CD34 CD34 NNP cord-005453-4057qib7 15949 9 + + CC cord-005453-4057qib7 15949 10 cell cell NN cord-005453-4057qib7 15949 11 subsets subset NNS cord-005453-4057qib7 15949 12 and and CC cord-005453-4057qib7 15949 13 lymphocyte lymphocyte NN cord-005453-4057qib7 15949 14 subsets subset NNS cord-005453-4057qib7 15949 15 of of IN cord-005453-4057qib7 15949 16 the the DT cord-005453-4057qib7 15949 17 blood blood NN cord-005453-4057qib7 15949 18 grafts graft NNS cord-005453-4057qib7 15949 19 , , , cord-005453-4057qib7 15949 20 post post JJ cord-005453-4057qib7 15949 21 - - JJ cord-005453-4057qib7 15949 22 transplant transplant JJ cord-005453-4057qib7 15949 23 hematological hematological JJ cord-005453-4057qib7 15949 24 recovery recovery NN cord-005453-4057qib7 15949 25 and and CC cord-005453-4057qib7 15949 26 outcome outcome NN cord-005453-4057qib7 15949 27 were be VBD cord-005453-4057qib7 15949 28 evaluated evaluate VBN cord-005453-4057qib7 15949 29 . . . cord-005453-4057qib7 15950 1 The the DT cord-005453-4057qib7 15950 2 median median JJ cord-005453-4057qib7 15950 3 followup followup JJ cord-005453-4057qib7 15950 4 time time NN cord-005453-4057qib7 15950 5 was be VBD cord-005453-4057qib7 15950 6 46 46 CD cord-005453-4057qib7 15950 7 months month NNS cord-005453-4057qib7 15950 8 in in IN cord-005453-4057qib7 15950 9 MM MM NNP cord-005453-4057qib7 15950 10 patients patient NNS cord-005453-4057qib7 15950 11 and and CC cord-005453-4057qib7 15950 12 35 35 CD cord-005453-4057qib7 15950 13 months month NNS cord-005453-4057qib7 15950 14 in in IN cord-005453-4057qib7 15950 15 NHL NHL NNP cord-005453-4057qib7 15950 16 patients patient NNS cord-005453-4057qib7 15950 17 . . . cord-005453-4057qib7 15951 1 Results result NNS cord-005453-4057qib7 15951 2 : : : cord-005453-4057qib7 15952 1 MM MM NNP cord-005453-4057qib7 15952 2 patients patient NNS cord-005453-4057qib7 15952 3 mobilized mobilize VBD cord-005453-4057qib7 15952 4 CD34 CD34 NNP cord-005453-4057qib7 15952 5 + + CC cord-005453-4057qib7 15952 6 cells cell NNS cord-005453-4057qib7 15952 7 better well JJR cord-005453-4057qib7 15952 8 ( ( -LRB- cord-005453-4057qib7 15952 9 median median JJ cord-005453-4057qib7 15952 10 peak peak NN cord-005453-4057qib7 15952 11 blood blood NN cord-005453-4057qib7 15952 12 CD34 CD34 NNP cord-005453-4057qib7 15953 1 + + CC cord-005453-4057qib7 15953 2 65 65 CD cord-005453-4057qib7 15954 1 vs. vs. NN cord-005453-4057qib7 15954 2 40 40 CD cord-005453-4057qib7 15954 3 x x SYM cord-005453-4057qib7 15954 4 10 10 CD cord-005453-4057qib7 15954 5 6 6 CD cord-005453-4057qib7 15954 6 /L /l NN cord-005453-4057qib7 15954 7 , , , cord-005453-4057qib7 15954 8 p p NN cord-005453-4057qib7 15954 9 < < XX cord-005453-4057qib7 15954 10 0.001 0.001 CD cord-005453-4057qib7 15954 11 ) ) -RRB- cord-005453-4057qib7 15954 12 . . . cord-005453-4057qib7 15955 1 The the DT cord-005453-4057qib7 15955 2 median median JJ cord-005453-4057qib7 15955 3 number number NN cord-005453-4057qib7 15955 4 of of IN cord-005453-4057qib7 15955 5 aphereses apherese NNS cord-005453-4057qib7 15955 6 was be VBD cord-005453-4057qib7 15955 7 2 2 CD cord-005453-4057qib7 15955 8 in in IN cord-005453-4057qib7 15955 9 both both DT cord-005453-4057qib7 15955 10 groups group NNS cord-005453-4057qib7 15956 1 ( ( -LRB- cord-005453-4057qib7 15956 2 p p NN cord-005453-4057qib7 15956 3 = = SYM cord-005453-4057qib7 15956 4 0.09 0.09 CD cord-005453-4057qib7 15956 5 ) ) -RRB- cord-005453-4057qib7 15956 6 . . . cord-005453-4057qib7 15957 1 Altogether altogether RB cord-005453-4057qib7 15957 2 26 26 CD cord-005453-4057qib7 15957 3 % % NN cord-005453-4057qib7 15957 4 of of IN cord-005453-4057qib7 15957 5 the the DT cord-005453-4057qib7 15957 6 NHL NHL NNP cord-005453-4057qib7 15957 7 patients patient NNS cord-005453-4057qib7 15957 8 received receive VBD cord-005453-4057qib7 15957 9 plerixafor plerixafor NN cord-005453-4057qib7 15957 10 compared compare VBN cord-005453-4057qib7 15957 11 to to IN cord-005453-4057qib7 15957 12 12 12 CD cord-005453-4057qib7 15957 13 % % NN cord-005453-4057qib7 15957 14 in in IN cord-005453-4057qib7 15957 15 MM MM NNP cord-005453-4057qib7 15957 16 patients patient NNS cord-005453-4057qib7 15957 17 ( ( -LRB- cord-005453-4057qib7 15957 18 p p NN cord-005453-4057qib7 15957 19 = = SYM cord-005453-4057qib7 15957 20 0.002 0.002 CD cord-005453-4057qib7 15957 21 ) ) -RRB- cord-005453-4057qib7 15957 22 . . . cord-005453-4057qib7 15958 1 The the DT cord-005453-4057qib7 15958 2 median median JJ cord-005453-4057qib7 15958 3 number number NN cord-005453-4057qib7 15958 4 of of IN cord-005453-4057qib7 15958 5 CD34 CD34 NNP cord-005453-4057qib7 15958 6 + + CC cord-005453-4057qib7 15958 7 cells cell NNS cord-005453-4057qib7 15958 8 collected collect VBN cord-005453-4057qib7 15958 9 was be VBD cord-005453-4057qib7 15958 10 higher high JJR cord-005453-4057qib7 15958 11 in in IN cord-005453-4057qib7 15958 12 MM MM NNP cord-005453-4057qib7 15958 13 patients patient NNS cord-005453-4057qib7 15958 14 ( ( -LRB- cord-005453-4057qib7 15958 15 6.4 6.4 CD cord-005453-4057qib7 15958 16 vs. vs. CC cord-005453-4057qib7 15958 17 3.9 3.9 CD cord-005453-4057qib7 15958 18 x x SYM cord-005453-4057qib7 15958 19 10 10 CD cord-005453-4057qib7 15958 20 6 6 CD cord-005453-4057qib7 15958 21 /kg /kg NN cord-005453-4057qib7 15958 22 , , , cord-005453-4057qib7 15958 23 p p NN cord-005453-4057qib7 15958 24 < < XX cord-005453-4057qib7 15958 25 0.001).The 0.001).the CD cord-005453-4057qib7 15958 26 median median NN cord-005453-4057qib7 15958 27 amount amount NN cord-005453-4057qib7 15958 28 of of IN cord-005453-4057qib7 15958 29 CD34 CD34 NNP cord-005453-4057qib7 15958 30 + + CC cord-005453-4057qib7 15958 31 cells cell NNS cord-005453-4057qib7 15958 32 ( ( -LRB- cord-005453-4057qib7 15958 33 with with IN cord-005453-4057qib7 15958 34 7-aminoactinomycin 7-aminoactinomycin CD cord-005453-4057qib7 15958 35 ) ) -RRB- cord-005453-4057qib7 15958 36 in in IN cord-005453-4057qib7 15958 37 the the DT cord-005453-4057qib7 15958 38 infused infuse VBN cord-005453-4057qib7 15958 39 graft graft NN cord-005453-4057qib7 15958 40 was be VBD cord-005453-4057qib7 15958 41 2.35 2.35 CD cord-005453-4057qib7 15958 42 x x SYM cord-005453-4057qib7 15958 43 10 10 CD cord-005453-4057qib7 15958 44 6 6 CD cord-005453-4057qib7 15959 1 /kg /kg NFP cord-005453-4057qib7 15959 2 in in IN cord-005453-4057qib7 15959 3 MM MM NNP cord-005453-4057qib7 15959 4 group group NN cord-005453-4057qib7 15959 5 and and CC cord-005453-4057qib7 15959 6 2.5 2.5 CD cord-005453-4057qib7 15959 7 x x SYM cord-005453-4057qib7 15959 8 10 10 CD cord-005453-4057qib7 15959 9 6 6 CD cord-005453-4057qib7 15960 1 /kg /kg NFP cord-005453-4057qib7 15960 2 in in IN cord-005453-4057qib7 15960 3 NHL NHL NNP cord-005453-4057qib7 15960 4 group group NN cord-005453-4057qib7 15960 5 ( ( -LRB- cord-005453-4057qib7 15960 6 p p NN cord-005453-4057qib7 15960 7 = = SYM cord-005453-4057qib7 15960 8 0.02 0.02 CD cord-005453-4057qib7 15960 9 ) ) -RRB- cord-005453-4057qib7 15960 10 . . . cord-005453-4057qib7 15961 1 The the DT cord-005453-4057qib7 15961 2 grafts graft NNS cord-005453-4057qib7 15961 3 contained contain VBD cord-005453-4057qib7 15961 4 more more JJR cord-005453-4057qib7 15961 5 NK NK NNP cord-005453-4057qib7 15961 6 cells cell NNS cord-005453-4057qib7 15961 7 ( ( -LRB- cord-005453-4057qib7 15961 8 median median JJ cord-005453-4057qib7 15961 9 10.1 10.1 CD cord-005453-4057qib7 15961 10 vs. vs. CC cord-005453-4057qib7 15961 11 6.1 6.1 CD cord-005453-4057qib7 15961 12 x x SYM cord-005453-4057qib7 15961 13 10 10 CD cord-005453-4057qib7 15961 14 6 6 CD cord-005453-4057qib7 15961 15 /kg /kg NN cord-005453-4057qib7 15961 16 , , , cord-005453-4057qib7 15961 17 p p NN cord-005453-4057qib7 15961 18 = = SYM cord-005453-4057qib7 15961 19 0.01 0.01 CD cord-005453-4057qib7 15961 20 ) ) -RRB- cord-005453-4057qib7 15961 21 and and CC cord-005453-4057qib7 15961 22 CD19 CD19 NNP cord-005453-4057qib7 15961 23 + + CC cord-005453-4057qib7 15961 24 cells cell NNS cord-005453-4057qib7 15961 25 ( ( -LRB- cord-005453-4057qib7 15961 26 median median NN cord-005453-4057qib7 15961 27 1.69 1.69 CD cord-005453-4057qib7 15961 28 vs. vs. NN cord-005453-4057qib7 15961 29 0.00 0.00 CD cord-005453-4057qib7 15961 30 x x SYM cord-005453-4057qib7 15961 31 10 10 CD cord-005453-4057qib7 15961 32 6 6 CD cord-005453-4057qib7 15961 33 /kg /kg NN cord-005453-4057qib7 15961 34 , , , cord-005453-4057qib7 15961 35 p p NN cord-005453-4057qib7 15961 36 < < XX cord-005453-4057qib7 15961 37 0.001 0.001 CD cord-005453-4057qib7 15961 38 ) ) -RRB- cord-005453-4057qib7 15961 39 in in IN cord-005453-4057qib7 15961 40 MM MM NNP cord-005453-4057qib7 15961 41 patients patient NNS cord-005453-4057qib7 15961 42 . . . cord-005453-4057qib7 15962 1 Neutropenic neutropenic JJ cord-005453-4057qib7 15962 2 fever fever NN cord-005453-4057qib7 15962 3 tended tend VBD cord-005453-4057qib7 15962 4 to to TO cord-005453-4057qib7 15962 5 be be VB cord-005453-4057qib7 15962 6 more more RBR cord-005453-4057qib7 15962 7 common common JJ cord-005453-4057qib7 15962 8 in in IN cord-005453-4057qib7 15962 9 NHL NHL NNP cord-005453-4057qib7 15962 10 patients patient NNS cord-005453-4057qib7 15962 11 ( ( -LRB- cord-005453-4057qib7 15962 12 88 88 CD cord-005453-4057qib7 15962 13 % % NN cord-005453-4057qib7 15962 14 vs. vs. CC cord-005453-4057qib7 15962 15 79 79 CD cord-005453-4057qib7 15962 16 % % NN cord-005453-4057qib7 15962 17 , , , cord-005453-4057qib7 15962 18 p p NN cord-005453-4057qib7 15962 19 = = SYM cord-005453-4057qib7 15962 20 0.06 0.06 CD cord-005453-4057qib7 15962 21 ) ) -RRB- cord-005453-4057qib7 15962 22 but but CC cord-005453-4057qib7 15962 23 MM MM NNP cord-005453-4057qib7 15962 24 patients patient NNS cord-005453-4057qib7 15962 25 had have VBD cord-005453-4057qib7 15962 26 significantly significantly RB cord-005453-4057qib7 15962 27 more more JJR cord-005453-4057qib7 15962 28 bloodstream bloodstream NN cord-005453-4057qib7 15962 29 infections infection NNS cord-005453-4057qib7 15962 30 ( ( -LRB- cord-005453-4057qib7 15962 31 31 31 CD cord-005453-4057qib7 15962 32 % % NN cord-005453-4057qib7 15962 33 vs. vs. IN cord-005453-4057qib7 15962 34 15 15 CD cord-005453-4057qib7 15962 35 % % NN cord-005453-4057qib7 15962 36 , , , cord-005453-4057qib7 15962 37 p p NN cord-005453-4057qib7 15962 38 = = SYM cord-005453-4057qib7 15962 39 0.003 0.003 CD cord-005453-4057qib7 15962 40 ) ) -RRB- cord-005453-4057qib7 15962 41 . . . cord-005453-4057qib7 15963 1 The the DT cord-005453-4057qib7 15963 2 median median JJ cord-005453-4057qib7 15963 3 duration duration NN cord-005453-4057qib7 15963 4 of of IN cord-005453-4057qib7 15963 5 hospitalization hospitalization NN cord-005453-4057qib7 15963 6 was be VBD cord-005453-4057qib7 15963 7 longer long JJR cord-005453-4057qib7 15963 8 in in IN cord-005453-4057qib7 15963 9 the the DT cord-005453-4057qib7 15963 10 NHL NHL NNP cord-005453-4057qib7 15963 11 patients patient NNS cord-005453-4057qib7 15963 12 ( ( -LRB- cord-005453-4057qib7 15963 13 22 22 CD cord-005453-4057qib7 15963 14 d d NN cord-005453-4057qib7 15963 15 vs. vs. NN cord-005453-4057qib7 15963 16 18 18 CD cord-005453-4057qib7 15963 17 d d NN cord-005453-4057qib7 15963 18 , , , cord-005453-4057qib7 15963 19 p p NN cord-005453-4057qib7 15963 20 < < XX cord-005453-4057qib7 15963 21 0.001 0.001 CD cord-005453-4057qib7 15963 22 ) ) -RRB- cord-005453-4057qib7 15963 23 and and CC cord-005453-4057qib7 15963 24 the the DT cord-005453-4057qib7 15963 25 NHL NHL NNP cord-005453-4057qib7 15963 26 patients patient NNS cord-005453-4057qib7 15963 27 had have VBD cord-005453-4057qib7 15963 28 significantly significantly RB cord-005453-4057qib7 15963 29 more more RBR cord-005453-4057qib7 15963 30 often often RB cord-005453-4057qib7 15963 31 ICU ICU NNP cord-005453-4057qib7 15963 32 admissions admission NNS cord-005453-4057qib7 15963 33 ( ( -LRB- cord-005453-4057qib7 15963 34 4 4 CD cord-005453-4057qib7 15963 35 % % NN cord-005453-4057qib7 15963 36 vs. vs. CC cord-005453-4057qib7 15963 37 0 0 CD cord-005453-4057qib7 15963 38 % % NN cord-005453-4057qib7 15963 39 , , , cord-005453-4057qib7 15963 40 p p NN cord-005453-4057qib7 15963 41 = = SYM cord-005453-4057qib7 15963 42 0.02).Post 0.02).post CD cord-005453-4057qib7 15963 43 - - HYPH cord-005453-4057qib7 15963 44 transplant transplant NN cord-005453-4057qib7 15963 45 neutrophil neutrophil NN cord-005453-4057qib7 15963 46 engraftment engraftment NN cord-005453-4057qib7 15963 47 was be VBD cord-005453-4057qib7 15963 48 faster fast JJR cord-005453-4057qib7 15963 49 in in IN cord-005453-4057qib7 15963 50 the the DT cord-005453-4057qib7 15963 51 NHL NHL NNP cord-005453-4057qib7 15963 52 group group NN cord-005453-4057qib7 15963 53 ( ( -LRB- cord-005453-4057qib7 15963 54 median median JJ cord-005453-4057qib7 15963 55 9 9 CD cord-005453-4057qib7 15963 56 d d NN cord-005453-4057qib7 15963 57 vs. vs. FW cord-005453-4057qib7 15963 58 12 12 CD cord-005453-4057qib7 15963 59 d d NN cord-005453-4057qib7 15963 60 , , , cord-005453-4057qib7 15963 61 p p NN cord-005453-4057qib7 15963 62 < < XX cord-005453-4057qib7 15963 63 0.001 0.001 CD cord-005453-4057qib7 15963 64 ) ) -RRB- cord-005453-4057qib7 15963 65 . . . cord-005453-4057qib7 15964 1 The the DT cord-005453-4057qib7 15964 2 median median JJ cord-005453-4057qib7 15964 3 time time NN cord-005453-4057qib7 15964 4 to to IN cord-005453-4057qib7 15964 5 platelet platelet NN cord-005453-4057qib7 15964 6 engraftment engraftment NN cord-005453-4057qib7 15964 7 was be VBD cord-005453-4057qib7 15964 8 11 11 CD cord-005453-4057qib7 15964 9 days day NNS cord-005453-4057qib7 15964 10 in in IN cord-005453-4057qib7 15964 11 both both DT cord-005453-4057qib7 15964 12 groups group NNS cord-005453-4057qib7 15964 13 . . . cord-005453-4057qib7 15965 1 Platelet platelet NN cord-005453-4057qib7 15965 2 count count NN cord-005453-4057qib7 15965 3 was be VBD cord-005453-4057qib7 15965 4 higher high JJR cord-005453-4057qib7 15965 5 in in IN cord-005453-4057qib7 15965 6 the the DT cord-005453-4057qib7 15965 7 MM MM NNP cord-005453-4057qib7 15965 8 group group NN cord-005453-4057qib7 15965 9 from from IN cord-005453-4057qib7 15965 10 day day NN cord-005453-4057qib7 15965 11 15 15 CD cord-005453-4057qib7 15965 12 until until IN cord-005453-4057qib7 15965 13 1 1 CD cord-005453-4057qib7 15965 14 year year NN cord-005453-4057qib7 15965 15 after after IN cord-005453-4057qib7 15965 16 auto auto NN cord-005453-4057qib7 15965 17 - - HYPH cord-005453-4057qib7 15965 18 SCT SCT NNP cord-005453-4057qib7 15965 19 . . . cord-005453-4057qib7 15966 1 There there EX cord-005453-4057qib7 15966 2 were be VBD cord-005453-4057qib7 15966 3 significantly significantly RB cord-005453-4057qib7 15966 4 more more JJR cord-005453-4057qib7 15966 5 early early JJ cord-005453-4057qib7 15966 6 deaths death NNS cord-005453-4057qib7 15966 7 ( ( -LRB- cord-005453-4057qib7 15966 8 < < XX cord-005453-4057qib7 15966 9 100 100 CD cord-005453-4057qib7 15966 10 d d XX cord-005453-4057qib7 15966 11 from from IN cord-005453-4057qib7 15966 12 the the DT cord-005453-4057qib7 15966 13 graft graft NN cord-005453-4057qib7 15966 14 infusion infusion NN cord-005453-4057qib7 15966 15 ) ) -RRB- cord-005453-4057qib7 15966 16 ( ( -LRB- cord-005453-4057qib7 15966 17 4 4 CD cord-005453-4057qib7 15966 18 % % NN cord-005453-4057qib7 15966 19 vs. vs. IN cord-005453-4057qib7 15966 20 0 0 CD cord-005453-4057qib7 15966 21 % % NN cord-005453-4057qib7 15966 22 , , , cord-005453-4057qib7 15966 23 p p NN cord-005453-4057qib7 15966 24 = = SYM cord-005453-4057qib7 15966 25 0.02 0.02 CD cord-005453-4057qib7 15966 26 ) ) -RRB- cord-005453-4057qib7 15966 27 and and CC cord-005453-4057qib7 15966 28 non non JJ cord-005453-4057qib7 15966 29 - - JJ cord-005453-4057qib7 15966 30 relapse relapse JJ cord-005453-4057qib7 15966 31 deaths death NNS cord-005453-4057qib7 15966 32 ( ( -LRB- cord-005453-4057qib7 15966 33 6 6 CD cord-005453-4057qib7 15966 34 % % NN cord-005453-4057qib7 15966 35 vs. vs. IN cord-005453-4057qib7 15966 36 0 0 CD cord-005453-4057qib7 15966 37 % % NN cord-005453-4057qib7 15966 38 , , , cord-005453-4057qib7 15966 39 p p NN cord-005453-4057qib7 15966 40 = = SYM cord-005453-4057qib7 15966 41 0.003 0.003 CD cord-005453-4057qib7 15966 42 ) ) -RRB- cord-005453-4057qib7 15966 43 in in IN cord-005453-4057qib7 15966 44 the the DT cord-005453-4057qib7 15966 45 NHL NHL NNP cord-005453-4057qib7 15966 46 group group NN cord-005453-4057qib7 15966 47 . . . cord-005453-4057qib7 15967 1 Conclusions conclusion NNS cord-005453-4057qib7 15967 2 : : : cord-005453-4057qib7 15968 1 MM MM NNP cord-005453-4057qib7 15968 2 and and CC cord-005453-4057qib7 15968 3 NHL NHL NNP cord-005453-4057qib7 15968 4 patients patient NNS cord-005453-4057qib7 15968 5 differ differ VBP cord-005453-4057qib7 15968 6 in in IN cord-005453-4057qib7 15968 7 terms term NNS cord-005453-4057qib7 15968 8 of of IN cord-005453-4057qib7 15968 9 CD34 CD34 NNP cord-005453-4057qib7 15968 10 + + CC cord-005453-4057qib7 15968 11 cell cell NN cord-005453-4057qib7 15968 12 mobilization mobilization NN cord-005453-4057qib7 15968 13 , , , cord-005453-4057qib7 15968 14 graft graft NN cord-005453-4057qib7 15968 15 cellular cellular JJ cord-005453-4057qib7 15968 16 composition composition NN cord-005453-4057qib7 15968 17 and and CC cord-005453-4057qib7 15968 18 post post JJ cord-005453-4057qib7 15968 19 - - JJ cord-005453-4057qib7 15968 20 transplant transplant JJ cord-005453-4057qib7 15968 21 recovery recovery NN cord-005453-4057qib7 15968 22 as as RB cord-005453-4057qib7 15968 23 well well RB cord-005453-4057qib7 15968 24 as as IN cord-005453-4057qib7 15968 25 risk risk NN cord-005453-4057qib7 15968 26 of of IN cord-005453-4057qib7 15968 27 non non JJ cord-005453-4057qib7 15968 28 - - JJ cord-005453-4057qib7 15968 29 relapse relapse JJ cord-005453-4057qib7 15968 30 death death NN cord-005453-4057qib7 15968 31 . . . cord-005453-4057qib7 15969 1 Thus thus RB cord-005453-4057qib7 15969 2 , , , cord-005453-4057qib7 15969 3 the the DT cord-005453-4057qib7 15969 4 optimal optimal JJ cord-005453-4057qib7 15969 5 graft graft NN cord-005453-4057qib7 15969 6 may may MD cord-005453-4057qib7 15969 7 be be VB cord-005453-4057qib7 15969 8 different different JJ cord-005453-4057qib7 15969 9 in in IN cord-005453-4057qib7 15969 10 NHL NHL NNP cord-005453-4057qib7 15969 11 and and CC cord-005453-4057qib7 15969 12 MM MM NNP cord-005453-4057qib7 15969 13 patients patient NNS cord-005453-4057qib7 15969 14 . . . cord-005453-4057qib7 15970 1 Disclosure disclosure NN cord-005453-4057qib7 15970 2 : : : cord-005453-4057qib7 15971 1 The the DT cord-005453-4057qib7 15971 2 study study NN cord-005453-4057qib7 15971 3 was be VBD cord-005453-4057qib7 15971 4 supported support VBN cord-005453-4057qib7 15971 5 by by IN cord-005453-4057qib7 15971 6 VTR VTR NNP cord-005453-4057qib7 15971 7 fund fund NN cord-005453-4057qib7 15971 8 from from IN cord-005453-4057qib7 15971 9 North North NNP cord-005453-4057qib7 15971 10 Savo Savo NNP cord-005453-4057qib7 15971 11 Hospital Hospital NNP cord-005453-4057qib7 15971 12 District District NNP cord-005453-4057qib7 15971 13 and and CC cord-005453-4057qib7 15971 14 study study NN cord-005453-4057qib7 15971 15 grant grant NN cord-005453-4057qib7 15971 16 from from IN cord-005453-4057qib7 15971 17 Sanofi Sanofi NNP cord-005453-4057qib7 15971 18 . . . cord-005453-4057qib7 15972 1 Abstract Abstract NNP cord-005453-4057qib7 15972 2 already already RB cord-005453-4057qib7 15972 3 published publish VBN cord-005453-4057qib7 15972 4 . . . cord-005453-4057qib7 15973 1 Single single JJ cord-005453-4057qib7 15973 2 - - HYPH cord-005453-4057qib7 15973 3 center center NN cord-005453-4057qib7 15973 4 experience experience NN cord-005453-4057qib7 15973 5 in in IN cord-005453-4057qib7 15973 6 use use NN cord-005453-4057qib7 15973 7 of of IN cord-005453-4057qib7 15973 8 plerixafor plerixafor NN cord-005453-4057qib7 15973 9 for for IN cord-005453-4057qib7 15973 10 autologous autologous JJ cord-005453-4057qib7 15973 11 stem stem NN cord-005453-4057qib7 15973 12 cell cell NN cord-005453-4057qib7 15973 13 mobilization mobilization NN cord-005453-4057qib7 15973 14 : : : cord-005453-4057qib7 15973 15 Change change VB cord-005453-4057qib7 15973 16 in in IN cord-005453-4057qib7 15973 17 practice practice NN cord-005453-4057qib7 15973 18 over over IN cord-005453-4057qib7 15973 19 10 10 CD cord-005453-4057qib7 15973 20 years year NNS cord-005453-4057qib7 15974 1 Background background NN cord-005453-4057qib7 15974 2 : : : cord-005453-4057qib7 15974 3 Plerixafor Plerixafor NNP cord-005453-4057qib7 15974 4 has have VBZ cord-005453-4057qib7 15974 5 been be VBN cord-005453-4057qib7 15974 6 proven prove VBN cord-005453-4057qib7 15974 7 to to TO cord-005453-4057qib7 15974 8 mobilize mobilize VB cord-005453-4057qib7 15974 9 human human JJ cord-005453-4057qib7 15974 10 periferal periferal JJ cord-005453-4057qib7 15974 11 blood blood NN cord-005453-4057qib7 15974 12 stem stem NN cord-005453-4057qib7 15974 13 cells cell NNS cord-005453-4057qib7 15974 14 ( ( -LRB- cord-005453-4057qib7 15974 15 PBSCs pbsc NNS cord-005453-4057qib7 15974 16 ) ) -RRB- cord-005453-4057qib7 15974 17 alone alone JJ cord-005453-4057qib7 15974 18 or or CC cord-005453-4057qib7 15974 19 acting act VBG cord-005453-4057qib7 15974 20 synergistically synergistically RB cord-005453-4057qib7 15974 21 with with IN cord-005453-4057qib7 15974 22 granulocyte granulocyte NN cord-005453-4057qib7 15974 23 - - HYPH cord-005453-4057qib7 15974 24 colony colony NN cord-005453-4057qib7 15974 25 stimulating stimulate VBG cord-005453-4057qib7 15974 26 factor factor NN cord-005453-4057qib7 15974 27 ( ( -LRB- cord-005453-4057qib7 15974 28 G G NNP cord-005453-4057qib7 15974 29 - - HYPH cord-005453-4057qib7 15974 30 CSF CSF NNP cord-005453-4057qib7 15974 31 ) ) -RRB- cord-005453-4057qib7 15974 32 . . . cord-005453-4057qib7 15975 1 It -PRON- PRP cord-005453-4057qib7 15975 2 has have VBZ cord-005453-4057qib7 15975 3 mainly mainly RB cord-005453-4057qib7 15975 4 been be VBN cord-005453-4057qib7 15975 5 used use VBN cord-005453-4057qib7 15975 6 for for IN cord-005453-4057qib7 15975 7 rescue rescue NN cord-005453-4057qib7 15975 8 mobilization mobilization NN cord-005453-4057qib7 15975 9 after after IN cord-005453-4057qib7 15975 10 failed fail VBN cord-005453-4057qib7 15975 11 regimen regimen NN cord-005453-4057qib7 15975 12 of of IN cord-005453-4057qib7 15975 13 chemotherapy chemotherapy NN cord-005453-4057qib7 15975 14 plus plus CC cord-005453-4057qib7 15975 15 G G NNP cord-005453-4057qib7 15975 16 - - HYPH cord-005453-4057qib7 15975 17 CSF CSF NNP cord-005453-4057qib7 15975 18 , , , cord-005453-4057qib7 15975 19 but but CC cord-005453-4057qib7 15975 20 lately lately RB cord-005453-4057qib7 15975 21 preemptive preemptive JJ cord-005453-4057qib7 15975 22 use use NN cord-005453-4057qib7 15975 23 in in IN cord-005453-4057qib7 15975 24 poor poor JJ cord-005453-4057qib7 15975 25 mobilizers mobilizer NNS cord-005453-4057qib7 15975 26 has have VBZ cord-005453-4057qib7 15975 27 been be VBN cord-005453-4057qib7 15975 28 established establish VBN cord-005453-4057qib7 15975 29 as as IN cord-005453-4057qib7 15975 30 cost cost NN cord-005453-4057qib7 15975 31 - - HYPH cord-005453-4057qib7 15975 32 effective effective JJ cord-005453-4057qib7 15975 33 . . . cord-005453-4057qib7 15976 1 We -PRON- PRP cord-005453-4057qib7 15976 2 aim aim VBP cord-005453-4057qib7 15976 3 to to TO cord-005453-4057qib7 15976 4 show show VB cord-005453-4057qib7 15976 5 ten ten CD cord-005453-4057qib7 15976 6 years year NNS cord-005453-4057qib7 15976 7 of of IN cord-005453-4057qib7 15976 8 experience experience NN cord-005453-4057qib7 15976 9 and and CC cord-005453-4057qib7 15976 10 change change NN cord-005453-4057qib7 15976 11 in in IN cord-005453-4057qib7 15976 12 practice practice NN cord-005453-4057qib7 15976 13 with with IN cord-005453-4057qib7 15976 14 plerixafor plerixafor NN cord-005453-4057qib7 15976 15 use use NN cord-005453-4057qib7 15976 16 in in IN cord-005453-4057qib7 15976 17 our -PRON- PRP$ cord-005453-4057qib7 15976 18 center center NN cord-005453-4057qib7 15976 19 . . . cord-005453-4057qib7 15977 1 Methods method NNS cord-005453-4057qib7 15977 2 : : : cord-005453-4057qib7 15977 3 We -PRON- PRP cord-005453-4057qib7 15977 4 retrospectively retrospectively RB cord-005453-4057qib7 15977 5 evaluated evaluate VBD cord-005453-4057qib7 15977 6 the the DT cord-005453-4057qib7 15977 7 outcome outcome NN cord-005453-4057qib7 15977 8 of of IN cord-005453-4057qib7 15977 9 mobilization mobilization NN cord-005453-4057qib7 15977 10 procedures procedure NNS cord-005453-4057qib7 15977 11 and and CC cord-005453-4057qib7 15977 12 leukapheresis leukapheresis NN cord-005453-4057qib7 15977 13 collections collection NNS cord-005453-4057qib7 15977 14 in in IN cord-005453-4057qib7 15977 15 our -PRON- PRP$ cord-005453-4057qib7 15977 16 center center NN cord-005453-4057qib7 15977 17 in in IN cord-005453-4057qib7 15977 18 the the DT cord-005453-4057qib7 15977 19 period period NN cord-005453-4057qib7 15977 20 from from IN cord-005453-4057qib7 15977 21 January January NNP cord-005453-4057qib7 15977 22 2009 2009 CD cord-005453-4057qib7 15977 23 to to IN cord-005453-4057qib7 15977 24 October October NNP cord-005453-4057qib7 15977 25 2018 2018 CD cord-005453-4057qib7 15977 26 . . . cord-005453-4057qib7 15978 1 Practice practice NN cord-005453-4057qib7 15978 2 from from IN cord-005453-4057qib7 15978 3 the the DT cord-005453-4057qib7 15978 4 first first JJ cord-005453-4057qib7 15978 5 5 5 CD cord-005453-4057qib7 15978 6 years year NNS cord-005453-4057qib7 15978 7 , , , cord-005453-4057qib7 15978 8 when when WRB cord-005453-4057qib7 15978 9 plerixafor plerixafor NN cord-005453-4057qib7 15978 10 was be VBD cord-005453-4057qib7 15978 11 mainly mainly RB cord-005453-4057qib7 15978 12 used use VBN cord-005453-4057qib7 15978 13 as as IN cord-005453-4057qib7 15978 14 rescue rescue NN cord-005453-4057qib7 15978 15 agent agent NN cord-005453-4057qib7 15978 16 after after IN cord-005453-4057qib7 15978 17 failed fail VBN cord-005453-4057qib7 15978 18 attempt attempt NN cord-005453-4057qib7 15978 19 , , , cord-005453-4057qib7 15978 20 was be VBD cord-005453-4057qib7 15978 21 compared compare VBN cord-005453-4057qib7 15978 22 to to IN cord-005453-4057qib7 15978 23 period period NN cord-005453-4057qib7 15978 24 from from IN cord-005453-4057qib7 15978 25 2014 2014 CD cord-005453-4057qib7 15978 26 till till IN cord-005453-4057qib7 15978 27 present present JJ cord-005453-4057qib7 15978 28 when when WRB cord-005453-4057qib7 15978 29 preemptive preemptive JJ cord-005453-4057qib7 15978 30 use use NN cord-005453-4057qib7 15978 31 in in IN cord-005453-4057qib7 15978 32 poor poor JJ cord-005453-4057qib7 15978 33 mobilizers mobilizer NNS cord-005453-4057qib7 15978 34 ( ( -LRB- cord-005453-4057qib7 15978 35 defined define VBN cord-005453-4057qib7 15978 36 as as IN cord-005453-4057qib7 15978 37 CD34 CD34 NNP cord-005453-4057qib7 15978 38 + + CC cord-005453-4057qib7 15978 39 cell cell NN cord-005453-4057qib7 15978 40 counts count VBZ cord-005453-4057qib7 15978 41 < < XX cord-005453-4057qib7 15978 42 10 10 CD cord-005453-4057qib7 15979 1 x x SYM cord-005453-4057qib7 15979 2 10 10 CD cord-005453-4057qib7 15979 3 6 6 CD cord-005453-4057qib7 15979 4 /L /l CD cord-005453-4057qib7 15979 5 blood blood NN cord-005453-4057qib7 15979 6 ) ) -RRB- cord-005453-4057qib7 15979 7 was be VBD cord-005453-4057qib7 15979 8 established establish VBN cord-005453-4057qib7 15979 9 . . . cord-005453-4057qib7 15980 1 Results result NNS cord-005453-4057qib7 15980 2 : : : cord-005453-4057qib7 15981 1 In in IN cord-005453-4057qib7 15981 2 the the DT cord-005453-4057qib7 15981 3 period period NN cord-005453-4057qib7 15981 4 from from IN cord-005453-4057qib7 15981 5 2009 2009 CD cord-005453-4057qib7 15981 6 to to IN cord-005453-4057qib7 15981 7 2013 2013 CD cord-005453-4057qib7 15981 8 , , , cord-005453-4057qib7 15981 9 total total NN cord-005453-4057qib7 15981 10 of of IN cord-005453-4057qib7 15981 11 434 434 CD cord-005453-4057qib7 15981 12 patients patient NNS cord-005453-4057qib7 15981 13 underwent undergo VBD cord-005453-4057qib7 15981 14 collection collection NN cord-005453-4057qib7 15981 15 of of IN cord-005453-4057qib7 15981 16 autologous autologous JJ cord-005453-4057qib7 15981 17 PBSCs pbsc NNS cord-005453-4057qib7 15981 18 , , , cord-005453-4057qib7 15981 19 and and CC cord-005453-4057qib7 15981 20 55 55 CD cord-005453-4057qib7 15981 21 patients patient NNS cord-005453-4057qib7 15981 22 required require VBD cord-005453-4057qib7 15981 23 repeated repeated JJ cord-005453-4057qib7 15981 24 mobilization mobilization NN cord-005453-4057qib7 15981 25 cycles cycle NNS cord-005453-4057qib7 15981 26 ( ( -LRB- cord-005453-4057qib7 15981 27 12,7 12,7 CD cord-005453-4057qib7 15981 28 % % NN cord-005453-4057qib7 15981 29 ) ) -RRB- cord-005453-4057qib7 15981 30 . . . cord-005453-4057qib7 15982 1 G G NNP cord-005453-4057qib7 15982 2 - - HYPH cord-005453-4057qib7 15982 3 CSF CSF NNP cord-005453-4057qib7 15982 4 alone alone RB cord-005453-4057qib7 15982 5 was be VBD cord-005453-4057qib7 15982 6 used use VBN cord-005453-4057qib7 15982 7 in in IN cord-005453-4057qib7 15982 8 39 39 CD cord-005453-4057qib7 15982 9 patients patient NNS cord-005453-4057qib7 15982 10 and and CC cord-005453-4057qib7 15982 11 16 16 CD cord-005453-4057qib7 15982 12 patients patient NNS cord-005453-4057qib7 15982 13 ( ( -LRB- cord-005453-4057qib7 15982 14 29 29 CD cord-005453-4057qib7 15982 15 % % NN cord-005453-4057qib7 15982 16 ) ) -RRB- cord-005453-4057qib7 15982 17 recieved recieve VBD cord-005453-4057qib7 15982 18 combination combination NN cord-005453-4057qib7 15982 19 G G NNP cord-005453-4057qib7 15982 20 - - HYPH cord-005453-4057qib7 15982 21 CSF CSF NNP cord-005453-4057qib7 15982 22 with with IN cord-005453-4057qib7 15982 23 plerixafor plerixafor NN cord-005453-4057qib7 15982 24 . . . cord-005453-4057qib7 15983 1 This this DT cord-005453-4057qib7 15983 2 cohort cohort NN cord-005453-4057qib7 15983 3 consisted consist VBD cord-005453-4057qib7 15983 4 of of IN cord-005453-4057qib7 15983 5 10 10 CD cord-005453-4057qib7 15983 6 males male NNS cord-005453-4057qib7 15983 7 and and CC cord-005453-4057qib7 15983 8 6 6 CD cord-005453-4057qib7 15983 9 females female NNS cord-005453-4057qib7 15983 10 with with IN cord-005453-4057qib7 15983 11 Non Non NNP cord-005453-4057qib7 15983 12 - - NNP cord-005453-4057qib7 15983 13 Hodgkin Hodgkin NNP cord-005453-4057qib7 15983 14 ( ( -LRB- cord-005453-4057qib7 15983 15 NHL NHL NNP cord-005453-4057qib7 15983 16 ) ) -RRB- cord-005453-4057qib7 15983 17 and and CC cord-005453-4057qib7 15983 18 Hodgkin Hodgkin NNP cord-005453-4057qib7 15983 19 lymphoma lymphoma NN cord-005453-4057qib7 15983 20 ( ( -LRB- cord-005453-4057qib7 15983 21 MH MH NNP cord-005453-4057qib7 15983 22 ) ) -RRB- cord-005453-4057qib7 15983 23 ; ; : cord-005453-4057qib7 15983 24 13 13 CD cord-005453-4057qib7 15983 25 and and CC cord-005453-4057qib7 15983 26 3 3 CD cord-005453-4057qib7 15983 27 respectively respectively RB cord-005453-4057qib7 15983 28 . . . cord-005453-4057qib7 15984 1 We -PRON- PRP cord-005453-4057qib7 15984 2 noted note VBD cord-005453-4057qib7 15984 3 37 37 CD cord-005453-4057qib7 15984 4 unsuccessful unsuccessful JJ cord-005453-4057qib7 15984 5 mobilizations mobilization NNS cord-005453-4057qib7 15984 6 ( ( -LRB- cord-005453-4057qib7 15984 7 67,3 67,3 CD cord-005453-4057qib7 15984 8 % % NN cord-005453-4057qib7 15984 9 in in IN cord-005453-4057qib7 15984 10 repeated repeat VBN cord-005453-4057qib7 15984 11 mobilization mobilization NN cord-005453-4057qib7 15984 12 , , , cord-005453-4057qib7 15984 13 8,5 8,5 CD cord-005453-4057qib7 15984 14 % % NN cord-005453-4057qib7 15984 15 in in IN cord-005453-4057qib7 15984 16 total total NN cord-005453-4057qib7 15984 17 ) ) -RRB- cord-005453-4057qib7 15984 18 of of IN cord-005453-4057qib7 15984 19 which which WDT cord-005453-4057qib7 15984 20 one one CD cord-005453-4057qib7 15984 21 patient patient NN cord-005453-4057qib7 15984 22 was be VBD cord-005453-4057qib7 15984 23 from from IN cord-005453-4057qib7 15984 24 plerixafor plerixafor NNP cord-005453-4057qib7 15984 25 group group NN cord-005453-4057qib7 15984 26 ( ( -LRB- cord-005453-4057qib7 15984 27 6,3%).Background 6,3%).background CD cord-005453-4057qib7 15984 28 : : : cord-005453-4057qib7 15985 1 Transplantation transplantation NN cord-005453-4057qib7 15985 2 of of IN cord-005453-4057qib7 15985 3 HLA HLA NNP cord-005453-4057qib7 15985 4 - - HYPH cord-005453-4057qib7 15985 5 haploidentical haploidentical JJ cord-005453-4057qib7 15985 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 15985 7 stem stem NN cord-005453-4057qib7 15985 8 cells cell NNS cord-005453-4057qib7 15985 9 ( ( -LRB- cord-005453-4057qib7 15985 10 haplo haplo NNP cord-005453-4057qib7 15985 11 - - HYPH cord-005453-4057qib7 15985 12 HSCT HSCT NNP cord-005453-4057qib7 15985 13 ) ) -RRB- cord-005453-4057qib7 15985 14 is be VBZ cord-005453-4057qib7 15985 15 an an DT cord-005453-4057qib7 15985 16 established establish VBN cord-005453-4057qib7 15985 17 procedure procedure NN cord-005453-4057qib7 15985 18 for for IN cord-005453-4057qib7 15985 19 the the DT cord-005453-4057qib7 15985 20 treatment treatment NN cord-005453-4057qib7 15985 21 of of IN cord-005453-4057qib7 15985 22 several several JJ cord-005453-4057qib7 15985 23 different different JJ cord-005453-4057qib7 15985 24 hematological hematological JJ cord-005453-4057qib7 15985 25 diseases disease NNS cord-005453-4057qib7 15985 26 . . . cord-005453-4057qib7 15986 1 One one CD cord-005453-4057qib7 15986 2 possible possible JJ cord-005453-4057qib7 15986 3 strategy strategy NN cord-005453-4057qib7 15986 4 to to TO cord-005453-4057qib7 15986 5 reduce reduce VB cord-005453-4057qib7 15986 6 the the DT cord-005453-4057qib7 15986 7 risk risk NN cord-005453-4057qib7 15986 8 of of IN cord-005453-4057qib7 15986 9 Graft graft NN cord-005453-4057qib7 15986 10 - - HYPH cord-005453-4057qib7 15986 11 versus versus IN cord-005453-4057qib7 15986 12 - - HYPH cord-005453-4057qib7 15986 13 Host Host NNP cord-005453-4057qib7 15986 14 Disease Disease NNP cord-005453-4057qib7 15986 15 is be VBZ cord-005453-4057qib7 15986 16 represented represent VBN cord-005453-4057qib7 15986 17 by by IN cord-005453-4057qib7 15986 18 the the DT cord-005453-4057qib7 15986 19 selective selective JJ cord-005453-4057qib7 15986 20 depletion depletion NN cord-005453-4057qib7 15986 21 of of IN cord-005453-4057qib7 15986 22 ab ab NNP cord-005453-4057qib7 15986 23 T t NN cord-005453-4057qib7 15986 24 - - HYPH cord-005453-4057qib7 15986 25 lymphocytes lymphocyte NNS cord-005453-4057qib7 15986 26 ( ( -LRB- cord-005453-4057qib7 15986 27 coupled couple VBN cord-005453-4057qib7 15986 28 with with IN cord-005453-4057qib7 15986 29 the the DT cord-005453-4057qib7 15986 30 depletion depletion NN cord-005453-4057qib7 15986 31 of of IN cord-005453-4057qib7 15986 32 CD19 CD19 NNP cord-005453-4057qib7 15986 33 + + CC cord-005453-4057qib7 15986 34 B b NN cord-005453-4057qib7 15986 35 - - HYPH cord-005453-4057qib7 15986 36 cells cell NNS cord-005453-4057qib7 15986 37 in in IN cord-005453-4057qib7 15986 38 order order NN cord-005453-4057qib7 15986 39 to to TO cord-005453-4057qib7 15986 40 reduce reduce VB cord-005453-4057qib7 15986 41 the the DT cord-005453-4057qib7 15986 42 risk risk NN cord-005453-4057qib7 15986 43 of of IN cord-005453-4057qib7 15986 44 PTLD PTLD NNP cord-005453-4057qib7 15986 45 ) ) -RRB- cord-005453-4057qib7 15986 46 using use VBG cord-005453-4057qib7 15986 47 the the DT cord-005453-4057qib7 15986 48 CliniMACS CliniMACS NNP cord-005453-4057qib7 15986 49 device device NN cord-005453-4057qib7 15986 50 ( ( -LRB- cord-005453-4057qib7 15986 51 Miltenyi Miltenyi NNP cord-005453-4057qib7 15986 52 , , , cord-005453-4057qib7 15986 53 Bergish Bergish NNP cord-005453-4057qib7 15986 54 - - HYPH cord-005453-4057qib7 15986 55 Gladback Gladback NNP cord-005453-4057qib7 15986 56 ) ) -RRB- cord-005453-4057qib7 15986 57 . . . cord-005453-4057qib7 15987 1 Before before IN cord-005453-4057qib7 15987 2 depletion depletion NN cord-005453-4057qib7 15987 3 , , , cord-005453-4057qib7 15987 4 leukapheresis leukapheresis NN cord-005453-4057qib7 15987 5 units unit NNS cord-005453-4057qib7 15987 6 are be VBP cord-005453-4057qib7 15987 7 washed wash VBN cord-005453-4057qib7 15987 8 by by IN cord-005453-4057qib7 15987 9 lowspeed lowspeed NN cord-005453-4057qib7 15987 10 centrifugation centrifugation NN cord-005453-4057qib7 15987 11 , , , cord-005453-4057qib7 15987 12 resulting result VBG cord-005453-4057qib7 15987 13 in in IN cord-005453-4057qib7 15987 14 a a DT cord-005453-4057qib7 15987 15 platelet platelet NN cord-005453-4057qib7 15987 16 ( ( -LRB- cord-005453-4057qib7 15987 17 PLT PLT NNP cord-005453-4057qib7 15987 18 ) ) -RRB- cord-005453-4057qib7 15987 19 rich rich JJ cord-005453-4057qib7 15987 20 supernatant supernatant NN cord-005453-4057qib7 15987 21 ( ( -LRB- cord-005453-4057qib7 15987 22 PRS PRS NNP cord-005453-4057qib7 15987 23 ) ) -RRB- cord-005453-4057qib7 15987 24 as as IN cord-005453-4057qib7 15987 25 a a DT cord-005453-4057qib7 15987 26 by by IN cord-005453-4057qib7 15987 27 - - HYPH cord-005453-4057qib7 15987 28 product product NN cord-005453-4057qib7 15987 29 generally generally RB cord-005453-4057qib7 15987 30 discarded discard VBN cord-005453-4057qib7 15987 31 . . . cord-005453-4057qib7 15988 1 We -PRON- PRP cord-005453-4057qib7 15988 2 studied study VBD cord-005453-4057qib7 15988 3 the the DT cord-005453-4057qib7 15988 4 possibility possibility NN cord-005453-4057qib7 15988 5 of of IN cord-005453-4057qib7 15988 6 recovering recover VBG cord-005453-4057qib7 15988 7 PLT PLT NNP cord-005453-4057qib7 15988 8 from from IN cord-005453-4057qib7 15988 9 PRS PRS NNP cord-005453-4057qib7 15988 10 of of IN cord-005453-4057qib7 15988 11 the the DT cord-005453-4057qib7 15988 12 haplo haplo NN cord-005453-4057qib7 15988 13 donor donor NN cord-005453-4057qib7 15988 14 for for IN cord-005453-4057qib7 15988 15 transfusion transfusion NN cord-005453-4057qib7 15988 16 to to IN cord-005453-4057qib7 15988 17 the the DT cord-005453-4057qib7 15988 18 recipient recipient NN cord-005453-4057qib7 15988 19 during during IN cord-005453-4057qib7 15988 20 the the DT cord-005453-4057qib7 15988 21 aplasia aplasia JJ cord-005453-4057qib7 15988 22 period period NN cord-005453-4057qib7 15988 23 occurring occur VBG cord-005453-4057qib7 15988 24 after after IN cord-005453-4057qib7 15988 25 HSCT.Methods hsct.method NNS cord-005453-4057qib7 15988 26 : : : cord-005453-4057qib7 15988 27 HSC HSC NNP cord-005453-4057qib7 15988 28 donors donor NNS cord-005453-4057qib7 15988 29 were be VBD cord-005453-4057qib7 15988 30 mobilized mobilize VBN cord-005453-4057qib7 15988 31 with with IN cord-005453-4057qib7 15988 32 G G NNP cord-005453-4057qib7 15988 33 - - HYPH cord-005453-4057qib7 15988 34 CSF CSF NNP cord-005453-4057qib7 15988 35 ( ( -LRB- cord-005453-4057qib7 15988 36 plus plus CC cord-005453-4057qib7 15988 37 Plerixafor Plerixafor NNP cord-005453-4057qib7 15988 38 in in IN cord-005453-4057qib7 15988 39 6 6 CD cord-005453-4057qib7 15988 40 out out IN cord-005453-4057qib7 15988 41 of of IN cord-005453-4057qib7 15988 42 24 24 CD cord-005453-4057qib7 15988 43 donors donor NNS cord-005453-4057qib7 15988 44 ) ) -RRB- cord-005453-4057qib7 15988 45 as as IN cord-005453-4057qib7 15988 46 previously previously RB cord-005453-4057qib7 15988 47 described describe VBN cord-005453-4057qib7 15988 48 [ [ -LRB- cord-005453-4057qib7 15988 49 Locatelli Locatelli NNP cord-005453-4057qib7 15988 50 et et NNP cord-005453-4057qib7 15988 51 al al NNP cord-005453-4057qib7 15988 52 , , , cord-005453-4057qib7 15988 53 Blood blood NN cord-005453-4057qib7 15988 54 2017 2017 CD cord-005453-4057qib7 15988 55 ] ] -RRB- cord-005453-4057qib7 15988 56 . . . cord-005453-4057qib7 15989 1 Leukapheresis leukapheresis NN cord-005453-4057qib7 15989 2 units unit NNS cord-005453-4057qib7 15989 3 , , , cord-005453-4057qib7 15989 4 obtained obtain VBN cord-005453-4057qib7 15989 5 with with IN cord-005453-4057qib7 15989 6 a a DT cord-005453-4057qib7 15989 7 Spectra Spectra NNP cord-005453-4057qib7 15989 8 Optia Optia NNP cord-005453-4057qib7 15989 9 device device NN cord-005453-4057qib7 15989 10 , , , cord-005453-4057qib7 15989 11 were be VBD cord-005453-4057qib7 15989 12 washed wash VBN cord-005453-4057qib7 15989 13 twice twice RB cord-005453-4057qib7 15989 14 ( ( -LRB- cord-005453-4057qib7 15989 15 producing produce VBG cord-005453-4057qib7 15989 16 2 2 CD cord-005453-4057qib7 15989 17 PRS PRS NNP cord-005453-4057qib7 15989 18 bags bag NNS cord-005453-4057qib7 15989 19 ) ) -RRB- cord-005453-4057qib7 15989 20 at at IN cord-005453-4057qib7 15989 21 low low JJ cord-005453-4057qib7 15989 22 speed speed NN cord-005453-4057qib7 15989 23 to to TO cord-005453-4057qib7 15989 24 remove remove VB cord-005453-4057qib7 15989 25 PLT PLT NNP cord-005453-4057qib7 15989 26 before before IN cord-005453-4057qib7 15989 27 starting start VBG cord-005453-4057qib7 15989 28 the the DT cord-005453-4057qib7 15989 29 ab ab NNP cord-005453-4057qib7 15989 30 T t NN cord-005453-4057qib7 15989 31 - - HYPH cord-005453-4057qib7 15989 32 cell cell NN cord-005453-4057qib7 15989 33 / / SYM cord-005453-4057qib7 15989 34 B b NN cord-005453-4057qib7 15989 35 - - HYPH cord-005453-4057qib7 15989 36 cell cell NN cord-005453-4057qib7 15989 37 depletion depletion NN cord-005453-4057qib7 15989 38 . . . cord-005453-4057qib7 15990 1 The the DT cord-005453-4057qib7 15990 2 two two CD cord-005453-4057qib7 15990 3 PRS PRS NNP cord-005453-4057qib7 15990 4 were be VBD cord-005453-4057qib7 15990 5 leukodepleted leukodeplete VBN cord-005453-4057qib7 15990 6 by by IN cord-005453-4057qib7 15990 7 filtration filtration NN cord-005453-4057qib7 15990 8 , , , cord-005453-4057qib7 15990 9 centrifuged centrifuge VBN cord-005453-4057qib7 15990 10 , , , cord-005453-4057qib7 15990 11 resuspended resuspended JJ cord-005453-4057qib7 15990 12 and and CC cord-005453-4057qib7 15990 13 pooled pool VBN cord-005453-4057qib7 15990 14 in in IN cord-005453-4057qib7 15990 15 a a DT cord-005453-4057qib7 15990 16 total total JJ cord-005453-4057qib7 15990 17 volume volume NN cord-005453-4057qib7 15990 18 ranging range VBG cord-005453-4057qib7 15990 19 from from IN cord-005453-4057qib7 15990 20 95 95 CD cord-005453-4057qib7 15990 21 to to TO cord-005453-4057qib7 15990 22 360 360 CD cord-005453-4057qib7 15990 23 ml ml NN cord-005453-4057qib7 15990 24 InterSol InterSol NNP cord-005453-4057qib7 15990 25 ( ( -LRB- cord-005453-4057qib7 15990 26 IS be VBZ cord-005453-4057qib7 15990 27 - - HYPH cord-005453-4057qib7 15990 28 PLT PLT NNP cord-005453-4057qib7 15990 29 ) ) -RRB- cord-005453-4057qib7 15990 30 for for IN cord-005453-4057qib7 15990 31 overnight overnight JJ cord-005453-4057qib7 15990 32 incubation incubation NN cord-005453-4057qib7 15990 33 at at IN cord-005453-4057qib7 15990 34 22 22 CD cord-005453-4057qib7 15990 35 ° ° NN cord-005453-4057qib7 15990 36 C c NN cord-005453-4057qib7 15990 37 with with IN cord-005453-4057qib7 15990 38 agitation agitation NN cord-005453-4057qib7 15990 39 ( ( -LRB- cord-005453-4057qib7 15990 40 60 60 CD cord-005453-4057qib7 15990 41 cycles cycle NNS cord-005453-4057qib7 15990 42 / / SYM cord-005453-4057qib7 15990 43 min min NN cord-005453-4057qib7 15990 44 ) ) -RRB- cord-005453-4057qib7 15990 45 . . . cord-005453-4057qib7 15991 1 The the DT cord-005453-4057qib7 15991 2 IS IS NNP cord-005453-4057qib7 15991 3 - - HYPH cord-005453-4057qib7 15991 4 PLT PLT NNP cord-005453-4057qib7 15991 5 samples sample NNS cord-005453-4057qib7 15991 6 were be VBD cord-005453-4057qib7 15991 7 analyzed analyze VBN cord-005453-4057qib7 15991 8 for for IN cord-005453-4057qib7 15991 9 the the DT cord-005453-4057qib7 15991 10 criteria criterion NNS cord-005453-4057qib7 15991 11 established establish VBN cord-005453-4057qib7 15991 12 by by IN cord-005453-4057qib7 15991 13 the the DT cord-005453-4057qib7 15991 14 Italian italian JJ cord-005453-4057qib7 15991 15 transfusion transfusion NN cord-005453-4057qib7 15991 16 law law NN cord-005453-4057qib7 15991 17 . . . cord-005453-4057qib7 15992 1 IS be VBZ cord-005453-4057qib7 15992 2 - - HYPH cord-005453-4057qib7 15992 3 PLT PLT NNP cord-005453-4057qib7 15992 4 bags bag NNS cord-005453-4057qib7 15992 5 were be VBD cord-005453-4057qib7 15992 6 examined examine VBN cord-005453-4057qib7 15992 7 for for IN cord-005453-4057qib7 15992 8 the the DT cord-005453-4057qib7 15992 9 following follow VBG cord-005453-4057qib7 15992 10 parameters parameter NNS cord-005453-4057qib7 15992 11 : : : cord-005453-4057qib7 15992 12 volume volume NN cord-005453-4057qib7 15992 13 > > XX cord-005453-4057qib7 15992 14 40ml 40ml NN cord-005453-4057qib7 15992 15 , , , cord-005453-4057qib7 15992 16 PLT PLT NNP cord-005453-4057qib7 15992 17 after after IN cord-005453-4057qib7 15992 18 leukodepletion leukodepletion NN cord-005453-4057qib7 15993 1 > > XX cord-005453-4057qib7 15994 1 2x10 2x10 CD cord-005453-4057qib7 15994 2 11 11 CD cord-005453-4057qib7 15994 3 , , , cord-005453-4057qib7 15994 4 residual residual JJ cord-005453-4057qib7 15994 5 leukocytes leukocyte NNS cord-005453-4057qib7 15994 6 < < XX cord-005453-4057qib7 15994 7 1x10 1x10 CD cord-005453-4057qib7 15994 8 6 6 CD cord-005453-4057qib7 15994 9 , , , cord-005453-4057qib7 15995 1 pH pH NNP cord-005453-4057qib7 15996 1 > > XX cord-005453-4057qib7 15997 1 6.4 6.4 CD cord-005453-4057qib7 15997 2 at at IN cord-005453-4057qib7 15997 3 22 22 CD cord-005453-4057qib7 15997 4 ° ° NN cord-005453-4057qib7 15997 5 C c NN cord-005453-4057qib7 15997 6 at at IN cord-005453-4057qib7 15997 7 the the DT cord-005453-4057qib7 15997 8 end end NN cord-005453-4057qib7 15997 9 of of IN cord-005453-4057qib7 15997 10 the the DT cord-005453-4057qib7 15997 11 5-day 5-day JJ cord-005453-4057qib7 15997 12 storage storage NN cord-005453-4057qib7 15997 13 period period NN cord-005453-4057qib7 15997 14 . . . cord-005453-4057qib7 15998 1 The the DT cord-005453-4057qib7 15998 2 sterility sterility NN cord-005453-4057qib7 15998 3 was be VBD cord-005453-4057qib7 15998 4 tested test VBN cord-005453-4057qib7 15998 5 using use VBG cord-005453-4057qib7 15998 6 BD BD NNP cord-005453-4057qib7 15998 7 Bactec Bactec NNP cord-005453-4057qib7 15998 8 culture culture NN cord-005453-4057qib7 15998 9 vials vial NNS cord-005453-4057qib7 15998 10 . . . cord-005453-4057qib7 15999 1 The the DT cord-005453-4057qib7 15999 2 evaluation evaluation NN cord-005453-4057qib7 15999 3 of of IN cord-005453-4057qib7 15999 4 the the DT cord-005453-4057qib7 15999 5 residual residual JJ cord-005453-4057qib7 15999 6 leukocytes leukocyte NNS cord-005453-4057qib7 15999 7 was be VBD cord-005453-4057qib7 15999 8 performed perform VBN cord-005453-4057qib7 15999 9 with with IN cord-005453-4057qib7 15999 10 the the DT cord-005453-4057qib7 15999 11 BD BD NNP cord-005453-4057qib7 15999 12 LeucoCount LeucoCount NNP cord-005453-4057qib7 15999 13 Kit Kit NNP cord-005453-4057qib7 15999 14 . . . cord-005453-4057qib7 16000 1 The the DT cord-005453-4057qib7 16000 2 absolute absolute JJ cord-005453-4057qib7 16000 3 PLT PLT NNP cord-005453-4057qib7 16000 4 counts count NNS cord-005453-4057qib7 16000 5 were be VBD cord-005453-4057qib7 16000 6 determined determine VBN cord-005453-4057qib7 16000 7 using use VBG cord-005453-4057qib7 16000 8 hemocytometer hemocytometer NN cord-005453-4057qib7 16000 9 Sysmex Sysmex NNP cord-005453-4057qib7 16000 10 XN2000.Results XN2000.Results NNP cord-005453-4057qib7 16000 11 : : : cord-005453-4057qib7 16001 1 PRS PRS NNP cord-005453-4057qib7 16001 2 bags bag NNS cord-005453-4057qib7 16001 3 from from IN cord-005453-4057qib7 16001 4 24 24 CD cord-005453-4057qib7 16001 5 donors donor NNS cord-005453-4057qib7 16001 6 were be VBD cord-005453-4057qib7 16001 7 processed process VBN cord-005453-4057qib7 16001 8 to to TO cord-005453-4057qib7 16001 9 produce produce VB cord-005453-4057qib7 16001 10 IS be VBZ cord-005453-4057qib7 16001 11 - - HYPH cord-005453-4057qib7 16001 12 PLT PLT NNP cord-005453-4057qib7 16001 13 units unit NNS cord-005453-4057qib7 16001 14 . . . cord-005453-4057qib7 16002 1 Median median JJ cord-005453-4057qib7 16002 2 resuspension resuspension NN cord-005453-4057qib7 16002 3 volume volume NN cord-005453-4057qib7 16002 4 in in IN cord-005453-4057qib7 16002 5 InterSol InterSol NNP cord-005453-4057qib7 16002 6 was be VBD cord-005453-4057qib7 16002 7 220 220 CD cord-005453-4057qib7 16002 8 ml ml NN cord-005453-4057qib7 16002 9 ( ( -LRB- cord-005453-4057qib7 16002 10 range range VB cord-005453-4057qib7 16002 11 95 95 CD cord-005453-4057qib7 16002 12 - - HYPH cord-005453-4057qib7 16002 13 360 360 CD cord-005453-4057qib7 16002 14 ) ) -RRB- cord-005453-4057qib7 16002 15 . . . cord-005453-4057qib7 16003 1 The the DT cord-005453-4057qib7 16003 2 absolute absolute JJ cord-005453-4057qib7 16003 3 mean mean JJ cord-005453-4057qib7 16003 4 value value NN cord-005453-4057qib7 16003 5 of of IN cord-005453-4057qib7 16003 6 PLT PLT NNP cord-005453-4057qib7 16003 7 counts count NNS cord-005453-4057qib7 16003 8 measured measure VBN cord-005453-4057qib7 16003 9 at at IN cord-005453-4057qib7 16003 10 the the DT cord-005453-4057qib7 16003 11 end end NN cord-005453-4057qib7 16003 12 of of IN cord-005453-4057qib7 16003 13 the the DT cord-005453-4057qib7 16003 14 storage storage NN cord-005453-4057qib7 16003 15 period period NN cord-005453-4057qib7 16003 16 was be VBD cord-005453-4057qib7 16003 17 2.1 2.1 CD cord-005453-4057qib7 16003 18 x10 x10 CD cord-005453-4057qib7 16003 19 11 11 CD cord-005453-4057qib7 16003 20 ( ( -LRB- cord-005453-4057qib7 16003 21 range range VBP cord-005453-4057qib7 16003 22 1.0 1.0 CD cord-005453-4057qib7 16003 23 - - SYM cord-005453-4057qib7 16003 24 6.1 6.1 CD cord-005453-4057qib7 16003 25 x10 x10 CD cord-005453-4057qib7 16003 26 11 11 CD cord-005453-4057qib7 16003 27 ) ) -RRB- cord-005453-4057qib7 16003 28 . . . cord-005453-4057qib7 16004 1 This this DT cord-005453-4057qib7 16004 2 value value NN cord-005453-4057qib7 16004 3 was be VBD cord-005453-4057qib7 16004 4 found find VBN cord-005453-4057qib7 16004 5 below below IN cord-005453-4057qib7 16004 6 the the DT cord-005453-4057qib7 16004 7 threshold threshold NN cord-005453-4057qib7 16004 8 fixed fix VBN cord-005453-4057qib7 16004 9 by by IN cord-005453-4057qib7 16004 10 Italian italian JJ cord-005453-4057qib7 16004 11 regulation regulation NN cord-005453-4057qib7 16004 12 in in IN cord-005453-4057qib7 16004 13 8 8 CD cord-005453-4057qib7 16004 14 cases case NNS cord-005453-4057qib7 16004 15 ( ( -LRB- cord-005453-4057qib7 16004 16 33.3 33.3 CD cord-005453-4057qib7 16004 17 % % NN cord-005453-4057qib7 16004 18 ) ) -RRB- cord-005453-4057qib7 16004 19 . . . cord-005453-4057qib7 16005 1 Mean mean JJ cord-005453-4057qib7 16005 2 value value NN cord-005453-4057qib7 16005 3 of of IN cord-005453-4057qib7 16005 4 residual residual JJ cord-005453-4057qib7 16005 5 leukocytes leukocyte NNS cord-005453-4057qib7 16005 6 was be VBD cord-005453-4057qib7 16005 7 1.3x10 1.3x10 CD cord-005453-4057qib7 16005 8 5 5 CD cord-005453-4057qib7 16006 1 ( ( -LRB- cord-005453-4057qib7 16006 2 range range NN cord-005453-4057qib7 16006 3 0 0 CD cord-005453-4057qib7 16006 4 - - HYPH cord-005453-4057qib7 16006 5 9x10 9x10 CD cord-005453-4057qib7 16006 6 5 5 CD cord-005453-4057qib7 16006 7 ) ) -RRB- cord-005453-4057qib7 16006 8 ; ; : cord-005453-4057qib7 16006 9 the the DT cord-005453-4057qib7 16006 10 pH pH NNP cord-005453-4057qib7 16006 11 value value NN cord-005453-4057qib7 16006 12 was be VBD cord-005453-4057qib7 16006 13 always always RB cord-005453-4057qib7 16006 14 > > XX cord-005453-4057qib7 16006 15 6.4 6.4 CD cord-005453-4057qib7 16006 16 . . . cord-005453-4057qib7 16007 1 Sterility sterility NN cord-005453-4057qib7 16007 2 was be VBD cord-005453-4057qib7 16007 3 observed observe VBN cord-005453-4057qib7 16007 4 in in IN cord-005453-4057qib7 16007 5 all all DT cord-005453-4057qib7 16007 6 cases case NNS cord-005453-4057qib7 16007 7 . . . cord-005453-4057qib7 16008 1 According accord VBG cord-005453-4057qib7 16008 2 to to IN cord-005453-4057qib7 16008 3 the the DT cord-005453-4057qib7 16008 4 work work NN cord-005453-4057qib7 16008 5 of of IN cord-005453-4057qib7 16008 6 Slichter Slichter NNP cord-005453-4057qib7 16008 7 et et NNP cord-005453-4057qib7 16008 8 al al NNP cord-005453-4057qib7 16008 9 . . . cord-005453-4057qib7 16009 1 Conclusions conclusion NNS cord-005453-4057qib7 16009 2 : : : cord-005453-4057qib7 16010 1 We -PRON- PRP cord-005453-4057qib7 16010 2 demonstrated demonstrate VBD cord-005453-4057qib7 16010 3 that that IN cord-005453-4057qib7 16010 4 PLTs plt NNS cord-005453-4057qib7 16010 5 recovered recover VBD cord-005453-4057qib7 16010 6 from from IN cord-005453-4057qib7 16010 7 leukapheresis leukapheresis NN cord-005453-4057qib7 16010 8 bags bag NNS cord-005453-4057qib7 16010 9 can can MD cord-005453-4057qib7 16010 10 be be VB cord-005453-4057qib7 16010 11 accepted accept VBN cord-005453-4057qib7 16010 12 as as IN cord-005453-4057qib7 16010 13 a a DT cord-005453-4057qib7 16010 14 conventional conventional JJ cord-005453-4057qib7 16010 15 hemocomponent hemocomponent NN cord-005453-4057qib7 16010 16 according accord VBG cord-005453-4057qib7 16010 17 to to IN cord-005453-4057qib7 16010 18 the the DT cord-005453-4057qib7 16010 19 parameters parameter NNS cord-005453-4057qib7 16010 20 fixed fix VBN cord-005453-4057qib7 16010 21 by by IN cord-005453-4057qib7 16010 22 Italian italian JJ cord-005453-4057qib7 16010 23 transfusion transfusion NN cord-005453-4057qib7 16010 24 law law NN cord-005453-4057qib7 16010 25 and and CC cord-005453-4057qib7 16010 26 thus thus RB cord-005453-4057qib7 16010 27 can can MD cord-005453-4057qib7 16010 28 be be VB cord-005453-4057qib7 16010 29 administered administer VBN cord-005453-4057qib7 16010 30 to to IN cord-005453-4057qib7 16010 31 the the DT cord-005453-4057qib7 16010 32 haplo haplo NNP cord-005453-4057qib7 16010 33 - - HYPH cord-005453-4057qib7 16010 34 HSCT HSCT NNP cord-005453-4057qib7 16010 35 recipients recipient NNS cord-005453-4057qib7 16010 36 early early RB cord-005453-4057qib7 16010 37 after after IN cord-005453-4057qib7 16010 38 transplantation transplantation NN cord-005453-4057qib7 16010 39 . . . cord-005453-4057qib7 16011 1 This this DT cord-005453-4057qib7 16011 2 strategy strategy NN cord-005453-4057qib7 16011 3 carries carry VBZ cord-005453-4057qib7 16011 4 several several JJ cord-005453-4057qib7 16011 5 advantages advantage NNS cord-005453-4057qib7 16011 6 . . . cord-005453-4057qib7 16012 1 Indeed indeed RB cord-005453-4057qib7 16012 2 , , , cord-005453-4057qib7 16012 3 apart apart RB cord-005453-4057qib7 16012 4 from from IN cord-005453-4057qib7 16012 5 the the DT cord-005453-4057qib7 16012 6 obvious obvious JJ cord-005453-4057qib7 16012 7 advantages advantage NNS cord-005453-4057qib7 16012 8 in in IN cord-005453-4057qib7 16012 9 terms term NNS cord-005453-4057qib7 16012 10 of of IN cord-005453-4057qib7 16012 11 reduced reduced JJ cord-005453-4057qib7 16012 12 costs cost NNS cord-005453-4057qib7 16012 13 , , , cord-005453-4057qib7 16012 14 IS be VBZ cord-005453-4057qib7 16012 15 - - HYPH cord-005453-4057qib7 16012 16 PLT PLT NNP cord-005453-4057qib7 16012 17 can can MD cord-005453-4057qib7 16012 18 be be VB cord-005453-4057qib7 16012 19 used use VBN cord-005453-4057qib7 16012 20 to to TO cord-005453-4057qib7 16012 21 desensitize desensitize VB cord-005453-4057qib7 16012 22 the the DT cord-005453-4057qib7 16012 23 recipient recipient NN cord-005453-4057qib7 16012 24 by by IN cord-005453-4057qib7 16012 25 absorption absorption NN cord-005453-4057qib7 16012 26 of of IN cord-005453-4057qib7 16012 27 anti anti JJ cord-005453-4057qib7 16012 28 - - JJ cord-005453-4057qib7 16012 29 HLA HLA NNP cord-005453-4057qib7 16012 30 class class NN cord-005453-4057qib7 16013 1 I -PRON- PRP cord-005453-4057qib7 16013 2 antibodies antibody NNS cord-005453-4057qib7 16013 3 , , , cord-005453-4057qib7 16013 4 if if IN cord-005453-4057qib7 16013 5 present present JJ cord-005453-4057qib7 16013 6 in in IN cord-005453-4057qib7 16013 7 the the DT cord-005453-4057qib7 16013 8 recipient recipient NN cord-005453-4057qib7 16013 9 . . . cord-005453-4057qib7 16014 1 Moreover moreover RB cord-005453-4057qib7 16014 2 , , , cord-005453-4057qib7 16014 3 this this DT cord-005453-4057qib7 16014 4 strategy strategy NN cord-005453-4057qib7 16014 5 can can MD cord-005453-4057qib7 16014 6 avoid avoid VB cord-005453-4057qib7 16014 7 the the DT cord-005453-4057qib7 16014 8 risk risk NN cord-005453-4057qib7 16014 9 of of IN cord-005453-4057qib7 16014 10 sensitizing sensitize VBG cord-005453-4057qib7 16014 11 the the DT cord-005453-4057qib7 16014 12 transplanted transplanted JJ cord-005453-4057qib7 16014 13 patients patient NNS cord-005453-4057qib7 16014 14 with with IN cord-005453-4057qib7 16014 15 HLA HLA NNP cord-005453-4057qib7 16014 16 alleles allele NNS cord-005453-4057qib7 16014 17 that that WDT cord-005453-4057qib7 16014 18 differ differ VBP cord-005453-4057qib7 16014 19 from from IN cord-005453-4057qib7 16014 20 the the DT cord-005453-4057qib7 16014 21 donor donor NN cord-005453-4057qib7 16014 22 's 's POS cord-005453-4057qib7 16014 23 ones one NNS cord-005453-4057qib7 16014 24 . . . cord-005453-4057qib7 16015 1 Finally finally RB cord-005453-4057qib7 16015 2 , , , cord-005453-4057qib7 16015 3 the the DT cord-005453-4057qib7 16015 4 IS IS NNP cord-005453-4057qib7 16015 5 - - HYPH cord-005453-4057qib7 16015 6 PLT PLT NNP cord-005453-4057qib7 16015 7 unit unit NN cord-005453-4057qib7 16015 8 is be VBZ cord-005453-4057qib7 16015 9 readily readily RB cord-005453-4057qib7 16015 10 available available JJ cord-005453-4057qib7 16015 11 . . . cord-005453-4057qib7 16016 1 A a DT cord-005453-4057qib7 16016 2 clinical clinical JJ cord-005453-4057qib7 16016 3 study study NN cord-005453-4057qib7 16016 4 aimed aim VBN cord-005453-4057qib7 16016 5 at at IN cord-005453-4057qib7 16016 6 testing test VBG cord-005453-4057qib7 16016 7 the the DT cord-005453-4057qib7 16016 8 use use NN cord-005453-4057qib7 16016 9 of of IN cord-005453-4057qib7 16016 10 IS IS NNP cord-005453-4057qib7 16016 11 - - HYPH cord-005453-4057qib7 16016 12 PLT PLT NNP cord-005453-4057qib7 16016 13 units unit NNS cord-005453-4057qib7 16016 14 in in IN cord-005453-4057qib7 16016 15 transplant transplant NN cord-005453-4057qib7 16016 16 recipients recipient NNS cord-005453-4057qib7 16016 17 will will MD cord-005453-4057qib7 16016 18 be be VB cord-005453-4057qib7 16016 19 performed perform VBN cord-005453-4057qib7 16016 20 to to TO cord-005453-4057qib7 16016 21 confirm confirm VB cord-005453-4057qib7 16016 22 the the DT cord-005453-4057qib7 16016 23 clinical clinical JJ cord-005453-4057qib7 16016 24 efficacy efficacy NN cord-005453-4057qib7 16016 25 of of IN cord-005453-4057qib7 16016 26 the the DT cord-005453-4057qib7 16016 27 approach approach NN cord-005453-4057qib7 16016 28 . . . cord-005453-4057qib7 16017 1 Disclosure disclosure NN cord-005453-4057qib7 16017 2 : : : cord-005453-4057qib7 16017 3 Nothing nothing NN cord-005453-4057qib7 16017 4 to to TO cord-005453-4057qib7 16017 5 declare declare VB cord-005453-4057qib7 16017 6 P700 P700 NNP cord-005453-4057qib7 16017 7 Ultrasound Ultrasound NNP cord-005453-4057qib7 16017 8 guidance guidance NN cord-005453-4057qib7 16017 9 as as IN cord-005453-4057qib7 16017 10 a a DT cord-005453-4057qib7 16017 11 powerful powerful JJ cord-005453-4057qib7 16017 12 tool tool NN cord-005453-4057qib7 16017 13 in in IN cord-005453-4057qib7 16017 14 increasing increase VBG cord-005453-4057qib7 16017 15 Background Background NNP cord-005453-4057qib7 16017 16 : : : cord-005453-4057qib7 16017 17 Peripheral peripheral JJ cord-005453-4057qib7 16017 18 blood blood NN cord-005453-4057qib7 16017 19 stem stem NN cord-005453-4057qib7 16017 20 cells cell NNS cord-005453-4057qib7 16017 21 are be VBP cord-005453-4057qib7 16017 22 generally generally RB cord-005453-4057qib7 16017 23 the the DT cord-005453-4057qib7 16017 24 preferred prefer VBN cord-005453-4057qib7 16017 25 graft graft NN cord-005453-4057qib7 16017 26 source source NN cord-005453-4057qib7 16017 27 for for IN cord-005453-4057qib7 16017 28 allogeneic allogeneic NN cord-005453-4057qib7 16017 29 stem stem NN cord-005453-4057qib7 16017 30 cell cell NN cord-005453-4057qib7 16017 31 transplantation transplantation NN cord-005453-4057qib7 16017 32 for for IN cord-005453-4057qib7 16017 33 malignant malignant JJ cord-005453-4057qib7 16017 34 disease disease NN cord-005453-4057qib7 16017 35 . . . cord-005453-4057qib7 16018 1 In in IN cord-005453-4057qib7 16018 2 most most JJS cord-005453-4057qib7 16018 3 centers center NNS cord-005453-4057qib7 16018 4 first first JJ cord-005453-4057qib7 16018 5 apheresis apheresis NN cord-005453-4057qib7 16018 6 is be VBZ cord-005453-4057qib7 16018 7 performed perform VBN cord-005453-4057qib7 16018 8 on on IN cord-005453-4057qib7 16018 9 day day NN cord-005453-4057qib7 16018 10 5 5 CD cord-005453-4057qib7 16018 11 after after IN cord-005453-4057qib7 16018 12 8 8 CD cord-005453-4057qib7 16018 13 to to TO cord-005453-4057qib7 16018 14 9 9 CD cord-005453-4057qib7 16018 15 doses dose NNS cord-005453-4057qib7 16018 16 of of IN cord-005453-4057qib7 16018 17 granulocyte granulocyte NN cord-005453-4057qib7 16018 18 colony colony NN cord-005453-4057qib7 16018 19 stimulating stimulate VBG cord-005453-4057qib7 16018 20 factor factor NN cord-005453-4057qib7 16018 21 ( ( -LRB- cord-005453-4057qib7 16018 22 GCSF GCSF NNP cord-005453-4057qib7 16018 23 ) ) -RRB- cord-005453-4057qib7 16018 24 up up IN cord-005453-4057qib7 16018 25 to to IN cord-005453-4057qib7 16018 26 5ug 5ug NNP cord-005453-4057qib7 16018 27 / / SYM cord-005453-4057qib7 16018 28 kg kg NN cord-005453-4057qib7 16018 29 twice twice RB cord-005453-4057qib7 16018 30 daily daily RB cord-005453-4057qib7 16018 31 . . . cord-005453-4057qib7 16019 1 The the DT cord-005453-4057qib7 16019 2 dose dose NN cord-005453-4057qib7 16019 3 of of IN cord-005453-4057qib7 16019 4 GCSF GCSF NNP cord-005453-4057qib7 16019 5 and and CC cord-005453-4057qib7 16019 6 the the DT cord-005453-4057qib7 16019 7 number number NN cord-005453-4057qib7 16019 8 of of IN cord-005453-4057qib7 16019 9 apheresis apheresis NN cord-005453-4057qib7 16019 10 procedures procedure NNS cord-005453-4057qib7 16019 11 required require VBN cord-005453-4057qib7 16019 12 contribute contribute VBP cord-005453-4057qib7 16019 13 to to IN cord-005453-4057qib7 16019 14 symptom symptom NN cord-005453-4057qib7 16019 15 , , , cord-005453-4057qib7 16019 16 travel travel NN cord-005453-4057qib7 16019 17 and and CC cord-005453-4057qib7 16019 18 time time NN cord-005453-4057qib7 16020 1 burden burden NN cord-005453-4057qib7 16020 2 donors donor NNS cord-005453-4057qib7 16020 3 are be VBP cord-005453-4057qib7 16020 4 put put VBN cord-005453-4057qib7 16020 5 through through RP cord-005453-4057qib7 16020 6 during during IN cord-005453-4057qib7 16020 7 the the DT cord-005453-4057qib7 16020 8 process process NN cord-005453-4057qib7 16020 9 . . . cord-005453-4057qib7 16021 1 We -PRON- PRP cord-005453-4057qib7 16021 2 hypothesized hypothesize VBD cord-005453-4057qib7 16021 3 that that IN cord-005453-4057qib7 16021 4 taking take VBG cord-005453-4057qib7 16021 5 donor donor NN cord-005453-4057qib7 16021 6 - - HYPH cord-005453-4057qib7 16021 7 recipient recipient NN cord-005453-4057qib7 16021 8 weight weight NN cord-005453-4057qib7 16021 9 differences difference NNS cord-005453-4057qib7 16021 10 into into IN cord-005453-4057qib7 16021 11 consideration consideration NN cord-005453-4057qib7 16021 12 may may MD cord-005453-4057qib7 16021 13 help help VB cord-005453-4057qib7 16021 14 reduce reduce VB cord-005453-4057qib7 16021 15 this this DT cord-005453-4057qib7 16021 16 burden burden NN cord-005453-4057qib7 16021 17 Methods method NNS cord-005453-4057qib7 16021 18 : : : cord-005453-4057qib7 16021 19 A a DT cord-005453-4057qib7 16021 20 total total NN cord-005453-4057qib7 16021 21 of of IN cord-005453-4057qib7 16021 22 261 261 CD cord-005453-4057qib7 16021 23 healthy healthy JJ cord-005453-4057qib7 16021 24 donors donor NNS cord-005453-4057qib7 16021 25 who who WP cord-005453-4057qib7 16021 26 donated donate VBD cord-005453-4057qib7 16021 27 peripheral peripheral JJ cord-005453-4057qib7 16021 28 blood blood NN cord-005453-4057qib7 16021 29 stem stem NN cord-005453-4057qib7 16021 30 cells cell NNS cord-005453-4057qib7 16021 31 on on IN cord-005453-4057qib7 16021 32 day day NN cord-005453-4057qib7 16021 33 4 4 CD cord-005453-4057qib7 16021 34 of of IN cord-005453-4057qib7 16021 35 GCSF GCSF NNP cord-005453-4057qib7 16021 36 mobilization mobilization NN cord-005453-4057qib7 16021 37 in in IN cord-005453-4057qib7 16021 38 the the DT cord-005453-4057qib7 16021 39 period period NN cord-005453-4057qib7 16021 40 between between IN cord-005453-4057qib7 16021 41 January January NNP cord-005453-4057qib7 16021 42 2015 2015 CD cord-005453-4057qib7 16021 43 and and CC cord-005453-4057qib7 16021 44 August August NNP cord-005453-4057qib7 16021 45 2018 2018 CD cord-005453-4057qib7 16021 46 at at IN cord-005453-4057qib7 16021 47 the the DT cord-005453-4057qib7 16021 48 University University NNP cord-005453-4057qib7 16021 49 Medical Medical NNP cord-005453-4057qib7 16021 50 Center Center NNP cord-005453-4057qib7 16021 51 Hamburg Hamburg NNP cord-005453-4057qib7 16021 52 - - HYPH cord-005453-4057qib7 16021 53 Eppendorf Eppendorf NNP cord-005453-4057qib7 16021 54 were be VBD cord-005453-4057qib7 16021 55 included include VBN cord-005453-4057qib7 16021 56 in in IN cord-005453-4057qib7 16021 57 this this DT cord-005453-4057qib7 16021 58 quality quality NN cord-005453-4057qib7 16021 59 control control NN cord-005453-4057qib7 16021 60 evaluation evaluation NN cord-005453-4057qib7 16021 61 . . . cord-005453-4057qib7 16022 1 The the DT cord-005453-4057qib7 16022 2 donors donor NNS cord-005453-4057qib7 16022 3 were be VBD cord-005453-4057qib7 16022 4 divided divide VBN cord-005453-4057qib7 16022 5 into into IN cord-005453-4057qib7 16022 6 two two CD cord-005453-4057qib7 16022 7 cohorts cohort NNS cord-005453-4057qib7 16022 8 . . . cord-005453-4057qib7 16023 1 The the DT cord-005453-4057qib7 16023 2 impact impact NN cord-005453-4057qib7 16023 3 of of IN cord-005453-4057qib7 16023 4 donorrecipient donorrecipient JJ cord-005453-4057qib7 16023 5 weight weight NN cord-005453-4057qib7 16023 6 ratio ratio NN cord-005453-4057qib7 16023 7 on on IN cord-005453-4057qib7 16023 8 stem stem NN cord-005453-4057qib7 16023 9 cell cell NN cord-005453-4057qib7 16023 10 harvest harvest NN cord-005453-4057qib7 16023 11 was be VBD cord-005453-4057qib7 16023 12 tested test VBN cord-005453-4057qib7 16023 13 in in IN cord-005453-4057qib7 16023 14 the the DT cord-005453-4057qib7 16023 15 training training NN cord-005453-4057qib7 16023 16 cohort cohort NN cord-005453-4057qib7 16023 17 ( ( -LRB- cord-005453-4057qib7 16023 18 2015 2015 CD cord-005453-4057qib7 16023 19 - - SYM cord-005453-4057qib7 16023 20 2016 2016 CD cord-005453-4057qib7 16023 21 ) ) -RRB- cord-005453-4057qib7 16023 22 and and CC cord-005453-4057qib7 16023 23 validated validate VBD cord-005453-4057qib7 16023 24 in in IN cord-005453-4057qib7 16023 25 the the DT cord-005453-4057qib7 16023 26 second second JJ cord-005453-4057qib7 16023 27 cohort cohort NN cord-005453-4057qib7 16023 28 ( ( -LRB- cord-005453-4057qib7 16023 29 2017 2017 CD cord-005453-4057qib7 16023 30 ) ) -RRB- cord-005453-4057qib7 16023 31 ( ( -LRB- cord-005453-4057qib7 16023 32 2018 2018 CD cord-005453-4057qib7 16023 33 ) ) -RRB- cord-005453-4057qib7 16023 34 . . . cord-005453-4057qib7 16024 1 For for IN cord-005453-4057qib7 16024 2 the the DT cord-005453-4057qib7 16024 3 training training NN cord-005453-4057qib7 16024 4 cohort cohort NN cord-005453-4057qib7 16024 5 , , , cord-005453-4057qib7 16024 6 donors donor NNS cord-005453-4057qib7 16024 7 were be VBD cord-005453-4057qib7 16024 8 grouped group VBN cord-005453-4057qib7 16024 9 according accord VBG cord-005453-4057qib7 16024 10 to to IN cord-005453-4057qib7 16024 11 donor donor NN cord-005453-4057qib7 16024 12 - - HYPH cord-005453-4057qib7 16024 13 recipient recipient NN cord-005453-4057qib7 16024 14 weight weight NN cord-005453-4057qib7 16024 15 ratio ratio NN cord-005453-4057qib7 16024 16 < < XX cord-005453-4057qib7 16024 17 1.0 1.0 CD cord-005453-4057qib7 16024 18 vs. vs. IN cord-005453-4057qib7 16024 19 1.0 1.0 CD cord-005453-4057qib7 16024 20 - - SYM cord-005453-4057qib7 16024 21 1.2 1.2 CD cord-005453-4057qib7 16024 22 vs. vs. FW cord-005453-4057qib7 16024 23 > > XX cord-005453-4057qib7 16024 24 1.2 1.2 CD cord-005453-4057qib7 16024 25 . . . cord-005453-4057qib7 16025 1 For for IN cord-005453-4057qib7 16025 2 the the DT cord-005453-4057qib7 16025 3 purpose purpose NN cord-005453-4057qib7 16025 4 of of IN cord-005453-4057qib7 16025 5 this this DT cord-005453-4057qib7 16025 6 analysis analysis NN cord-005453-4057qib7 16025 7 a a DT cord-005453-4057qib7 16025 8 stem stem NN cord-005453-4057qib7 16025 9 cells cell NNS cord-005453-4057qib7 16025 10 dose dose NN cord-005453-4057qib7 16025 11 of of IN cord-005453-4057qib7 16025 12 5 5 CD cord-005453-4057qib7 16025 13 x x SYM cord-005453-4057qib7 16025 14 10 10 CD cord-005453-4057qib7 16025 15 6 6 CD cord-005453-4057qib7 16025 16 CD34+/kg CD34+/kg NNP cord-005453-4057qib7 16025 17 recipient recipient NN cord-005453-4057qib7 16025 18 weight weight NN cord-005453-4057qib7 16025 19 was be VBD cord-005453-4057qib7 16025 20 set set VBN cord-005453-4057qib7 16025 21 for for IN cord-005453-4057qib7 16025 22 successful successful JJ cord-005453-4057qib7 16025 23 apheresis apheresis NN cord-005453-4057qib7 16025 24 . . . cord-005453-4057qib7 16026 1 Results result NNS cord-005453-4057qib7 16026 2 : : : cord-005453-4057qib7 16027 1 In in IN cord-005453-4057qib7 16027 2 the the DT cord-005453-4057qib7 16027 3 training training NN cord-005453-4057qib7 16027 4 cohort cohort NN cord-005453-4057qib7 16027 5 including include VBG cord-005453-4057qib7 16027 6 142 142 CD cord-005453-4057qib7 16027 7 donors donor NNS cord-005453-4057qib7 16027 8 , , , cord-005453-4057qib7 16027 9 52 52 CD cord-005453-4057qib7 16027 10 ( ( -LRB- cord-005453-4057qib7 16027 11 37 37 CD cord-005453-4057qib7 16027 12 % % NN cord-005453-4057qib7 16027 13 ) ) -RRB- cord-005453-4057qib7 16027 14 , , , cord-005453-4057qib7 16027 15 36 36 CD cord-005453-4057qib7 16027 16 ( ( -LRB- cord-005453-4057qib7 16027 17 25 25 CD cord-005453-4057qib7 16027 18 % % NN cord-005453-4057qib7 16027 19 ) ) -RRB- cord-005453-4057qib7 16027 20 and and CC cord-005453-4057qib7 16027 21 54 54 CD cord-005453-4057qib7 16027 22 ( ( -LRB- cord-005453-4057qib7 16027 23 38 38 CD cord-005453-4057qib7 16027 24 % % NN cord-005453-4057qib7 16027 25 ) ) -RRB- cord-005453-4057qib7 16027 26 had have VBD cord-005453-4057qib7 16027 27 a a DT cord-005453-4057qib7 16027 28 donor donor NN cord-005453-4057qib7 16027 29 - - HYPH cord-005453-4057qib7 16027 30 recipient recipient NN cord-005453-4057qib7 16027 31 weight weight NN cord-005453-4057qib7 16027 32 ratio ratio NN cord-005453-4057qib7 16027 33 of of IN cord-005453-4057qib7 16027 34 < < NNP cord-005453-4057qib7 16027 35 1.0 1.0 CD cord-005453-4057qib7 16027 36 , , , cord-005453-4057qib7 16028 1 1.0 1.0 CD cord-005453-4057qib7 16028 2 -1.2 -1.2 CD cord-005453-4057qib7 16028 3 and and CC cord-005453-4057qib7 16028 4 > > XX cord-005453-4057qib7 16028 5 1.2 1.2 CD cord-005453-4057qib7 16028 6 respectively respectively RB cord-005453-4057qib7 16028 7 . . . cord-005453-4057qib7 16029 1 The the DT cord-005453-4057qib7 16029 2 target target NN cord-005453-4057qib7 16029 3 stem stem NN cord-005453-4057qib7 16029 4 cells cell NNS cord-005453-4057qib7 16029 5 count count NN cord-005453-4057qib7 16029 6 of of IN cord-005453-4057qib7 16029 7 5 5 CD cord-005453-4057qib7 16029 8 x x SYM cord-005453-4057qib7 16029 9 10 10 CD cord-005453-4057qib7 16029 10 6 6 CD cord-005453-4057qib7 16029 11 CD34+/kg CD34+/kg NNP cord-005453-4057qib7 16029 12 recipient recipient NN cord-005453-4057qib7 16029 13 weight weight NN cord-005453-4057qib7 16029 14 was be VBD cord-005453-4057qib7 16029 15 achieved achieve VBN cord-005453-4057qib7 16029 16 in in IN cord-005453-4057qib7 16029 17 36 36 CD cord-005453-4057qib7 16029 18 of of IN cord-005453-4057qib7 16029 19 52 52 CD cord-005453-4057qib7 16029 20 ( ( -LRB- cord-005453-4057qib7 16029 21 69 69 CD cord-005453-4057qib7 16029 22 % % NN cord-005453-4057qib7 16029 23 ) ) -RRB- cord-005453-4057qib7 16029 24 , , , cord-005453-4057qib7 16029 25 26 26 CD cord-005453-4057qib7 16029 26 of of IN cord-005453-4057qib7 16029 27 36 36 CD cord-005453-4057qib7 16029 28 ( ( -LRB- cord-005453-4057qib7 16029 29 72 72 CD cord-005453-4057qib7 16029 30 % % NN cord-005453-4057qib7 16029 31 ) ) -RRB- cord-005453-4057qib7 16029 32 and and CC cord-005453-4057qib7 16029 33 45 45 CD cord-005453-4057qib7 16029 34 of of IN cord-005453-4057qib7 16029 35 54 54 CD cord-005453-4057qib7 16029 36 ( ( -LRB- cord-005453-4057qib7 16029 37 83 83 CD cord-005453-4057qib7 16029 38 % % NN cord-005453-4057qib7 16029 39 ) ) -RRB- cord-005453-4057qib7 16029 40 donors donor NNS cord-005453-4057qib7 16029 41 with with IN cord-005453-4057qib7 16029 42 donor donor NN cord-005453-4057qib7 16029 43 : : : cord-005453-4057qib7 16029 44 recipient recipient NN cord-005453-4057qib7 16029 45 weight weight NN cord-005453-4057qib7 16029 46 ratio ratio NN cord-005453-4057qib7 16029 47 < < XX cord-005453-4057qib7 16029 48 1.0 1.0 CD cord-005453-4057qib7 16029 49 , , , cord-005453-4057qib7 16030 1 1.0 1.0 CD cord-005453-4057qib7 16030 2 -1.2 -1.2 CD cord-005453-4057qib7 16030 3 and and CC cord-005453-4057qib7 16030 4 > > XX cord-005453-4057qib7 16030 5 1.2 1.2 CD cord-005453-4057qib7 16030 6 respectively respectively RB cord-005453-4057qib7 16030 7 . . . cord-005453-4057qib7 16031 1 The the DT cord-005453-4057qib7 16031 2 cut cut NN cord-005453-4057qib7 16031 3 - - HYPH cord-005453-4057qib7 16031 4 off off NN cord-005453-4057qib7 16031 5 for for IN cord-005453-4057qib7 16031 6 the the DT cord-005453-4057qib7 16031 7 validation validation NN cord-005453-4057qib7 16031 8 cohort cohort NN cord-005453-4057qib7 16031 9 was be VBD cord-005453-4057qib7 16031 10 therefore therefore RB cord-005453-4057qib7 16031 11 set set VBN cord-005453-4057qib7 16031 12 at at IN cord-005453-4057qib7 16031 13 a a DT cord-005453-4057qib7 16031 14 weight weight NN cord-005453-4057qib7 16031 15 ratio ratio NN cord-005453-4057qib7 16031 16 of of IN cord-005453-4057qib7 16031 17 1.2.In 1.2.in CD cord-005453-4057qib7 16031 18 der der NN cord-005453-4057qib7 16031 19 validation validation NN cord-005453-4057qib7 16031 20 cohort cohort NN cord-005453-4057qib7 16031 21 including include VBG cord-005453-4057qib7 16031 22 119 119 CD cord-005453-4057qib7 16031 23 donors donor NNS cord-005453-4057qib7 16031 24 , , , cord-005453-4057qib7 16031 25 75 75 CD cord-005453-4057qib7 16031 26 ( ( -LRB- cord-005453-4057qib7 16031 27 48 48 CD cord-005453-4057qib7 16031 28 % % NN cord-005453-4057qib7 16031 29 ) ) -RRB- cord-005453-4057qib7 16031 30 had have VBD cord-005453-4057qib7 16031 31 a a DT cord-005453-4057qib7 16031 32 weight weight NN cord-005453-4057qib7 16031 33 ratio ratio NN cord-005453-4057qib7 16031 34 > > XX cord-005453-4057qib7 16031 35 1.2 1.2 CD cord-005453-4057qib7 16031 36 while while IN cord-005453-4057qib7 16031 37 62 62 CD cord-005453-4057qib7 16031 38 ( ( -LRB- cord-005453-4057qib7 16031 39 52 52 CD cord-005453-4057qib7 16031 40 % % NN cord-005453-4057qib7 16031 41 ) ) -RRB- cord-005453-4057qib7 16031 42 had have VBD cord-005453-4057qib7 16031 43 a a DT cord-005453-4057qib7 16031 44 weight weight NN cord-005453-4057qib7 16031 45 ratio ratio NN cord-005453-4057qib7 16031 46 ≤ ≤ NN cord-005453-4057qib7 16031 47 1.2 1.2 CD cord-005453-4057qib7 16031 48 . . . cord-005453-4057qib7 16032 1 Overall overall RB cord-005453-4057qib7 16032 2 in in IN cord-005453-4057qib7 16032 3 this this DT cord-005453-4057qib7 16032 4 cohort cohort NN cord-005453-4057qib7 16032 5 target target NN cord-005453-4057qib7 16032 6 cell cell NN cord-005453-4057qib7 16032 7 count count NN cord-005453-4057qib7 16032 8 of of IN cord-005453-4057qib7 16032 9 5 5 CD cord-005453-4057qib7 16032 10 x x SYM cord-005453-4057qib7 16032 11 10 10 CD cord-005453-4057qib7 16032 12 6 6 CD cord-005453-4057qib7 16032 13 CD34 CD34 NNP cord-005453-4057qib7 16032 14 + + CC cord-005453-4057qib7 16032 15 /kg /kg CD cord-005453-4057qib7 16032 16 recipient recipient NN cord-005453-4057qib7 16032 17 weight weight NN cord-005453-4057qib7 16032 18 was be VBD cord-005453-4057qib7 16032 19 reached reach VBN cord-005453-4057qib7 16032 20 in in IN cord-005453-4057qib7 16032 21 92 92 CD cord-005453-4057qib7 16032 22 ( ( -LRB- cord-005453-4057qib7 16032 23 77 77 CD cord-005453-4057qib7 16032 24 % % NN cord-005453-4057qib7 16032 25 ) ) -RRB- cord-005453-4057qib7 16032 26 cases case NNS cord-005453-4057qib7 16032 27 . . . cord-005453-4057qib7 16033 1 This this DT cord-005453-4057qib7 16033 2 target target NN cord-005453-4057qib7 16033 3 was be VBD cord-005453-4057qib7 16033 4 reached reach VBN cord-005453-4057qib7 16033 5 in in IN cord-005453-4057qib7 16033 6 43 43 CD cord-005453-4057qib7 16033 7 of of IN cord-005453-4057qib7 16033 8 62 62 CD cord-005453-4057qib7 16033 9 ( ( -LRB- cord-005453-4057qib7 16033 10 69 69 CD cord-005453-4057qib7 16033 11 % % NN cord-005453-4057qib7 16033 12 ) ) -RRB- cord-005453-4057qib7 16033 13 of of IN cord-005453-4057qib7 16033 14 donors donor NNS cord-005453-4057qib7 16033 15 with with IN cord-005453-4057qib7 16033 16 weight weight NN cord-005453-4057qib7 16033 17 ratio ratio NN cord-005453-4057qib7 16033 18 ≤ ≤ NNP cord-005453-4057qib7 16033 19 1.2 1.2 CD cord-005453-4057qib7 16033 20 and and CC cord-005453-4057qib7 16033 21 in in IN cord-005453-4057qib7 16033 22 49 49 CD cord-005453-4057qib7 16033 23 of of IN cord-005453-4057qib7 16033 24 57 57 CD cord-005453-4057qib7 16033 25 ( ( -LRB- cord-005453-4057qib7 16033 26 86 86 CD cord-005453-4057qib7 16033 27 % % NN cord-005453-4057qib7 16033 28 ) ) -RRB- cord-005453-4057qib7 16033 29 donors donor NNS cord-005453-4057qib7 16033 30 with with IN cord-005453-4057qib7 16033 31 weight weight NN cord-005453-4057qib7 16033 32 ratio ratio NN cord-005453-4057qib7 16033 33 > > NNP cord-005453-4057qib7 16033 34 1.2 1.2 CD cord-005453-4057qib7 16033 35 , , , cord-005453-4057qib7 16033 36 p p NN cord-005453-4057qib7 16033 37 = = SYM cord-005453-4057qib7 16033 38 0.03.Conclusions 0.03.conclusion NNS cord-005453-4057qib7 16033 39 : : : cord-005453-4057qib7 16034 1 A a DT cord-005453-4057qib7 16034 2 donor donor NN cord-005453-4057qib7 16034 3 - - HYPH cord-005453-4057qib7 16034 4 recipient recipient NN cord-005453-4057qib7 16034 5 weight weight NN cord-005453-4057qib7 16034 6 ratio ratio NN cord-005453-4057qib7 16034 7 of of IN cord-005453-4057qib7 16034 8 > > $ cord-005453-4057qib7 16034 9 1.2 1.2 CD cord-005453-4057qib7 16034 10 is be VBZ cord-005453-4057qib7 16034 11 seen see VBN cord-005453-4057qib7 16034 12 in in IN cord-005453-4057qib7 16034 13 about about RB cord-005453-4057qib7 16034 14 40 40 CD cord-005453-4057qib7 16034 15 % % NN cord-005453-4057qib7 16034 16 of of IN cord-005453-4057qib7 16034 17 peripheral peripheral JJ cord-005453-4057qib7 16034 18 blood blood NN cord-005453-4057qib7 16034 19 stem stem NN cord-005453-4057qib7 16034 20 cell cell NN cord-005453-4057qib7 16034 21 donations donation NNS cord-005453-4057qib7 16034 22 for for IN cord-005453-4057qib7 16034 23 allogeneic allogeneic NN cord-005453-4057qib7 16034 24 stem stem NN cord-005453-4057qib7 16034 25 cell cell NN cord-005453-4057qib7 16034 26 transplantation transplantation NN cord-005453-4057qib7 16034 27 . . . cord-005453-4057qib7 16035 1 In in IN cord-005453-4057qib7 16035 2 these these DT cord-005453-4057qib7 16035 3 cases case NNS cord-005453-4057qib7 16035 4 apheresis apheresis NN cord-005453-4057qib7 16035 5 on on IN cord-005453-4057qib7 16035 6 day day NN cord-005453-4057qib7 16035 7 4 4 CD cord-005453-4057qib7 16035 8 after after IN cord-005453-4057qib7 16035 9 7 7 CD cord-005453-4057qib7 16035 10 doses dose NNS cord-005453-4057qib7 16035 11 of of IN cord-005453-4057qib7 16035 12 GCSF GCSF NNP cord-005453-4057qib7 16035 13 is be VBZ cord-005453-4057qib7 16035 14 reasonable reasonable JJ cord-005453-4057qib7 16035 15 . . . cord-005453-4057qib7 16036 1 Donors donor NNS cord-005453-4057qib7 16036 2 with with IN cord-005453-4057qib7 16036 3 lower low JJR cord-005453-4057qib7 16036 4 weight weight NN cord-005453-4057qib7 16036 5 ratios ratio NNS cord-005453-4057qib7 16036 6 should should MD cord-005453-4057qib7 16036 7 preferentially preferentially RB cord-005453-4057qib7 16036 8 donate donate VB cord-005453-4057qib7 16036 9 on on IN cord-005453-4057qib7 16036 10 day day NN cord-005453-4057qib7 16036 11 5 5 CD cord-005453-4057qib7 16036 12 after after IN cord-005453-4057qib7 16036 13 8 8 CD cord-005453-4057qib7 16036 14 to to TO cord-005453-4057qib7 16036 15 9 9 CD cord-005453-4057qib7 16036 16 doses dose NNS cord-005453-4057qib7 16036 17 of of IN cord-005453-4057qib7 16036 18 GCSF.Disclosure GCSF.Disclosure : cord-005453-4057qib7 16036 19 : : : cord-005453-4057qib7 16037 1 All all DT cord-005453-4057qib7 16037 2 authors author NNS cord-005453-4057qib7 16037 3 declare declare VBP cord-005453-4057qib7 16037 4 no no DT cord-005453-4057qib7 16037 5 conflicts conflict NNS cord-005453-4057qib7 16037 6 of of IN cord-005453-4057qib7 16037 7 interest interest NN cord-005453-4057qib7 16037 8 Background background NN cord-005453-4057qib7 16037 9 : : : cord-005453-4057qib7 16037 10 The the DT cord-005453-4057qib7 16037 11 effect effect NN cord-005453-4057qib7 16037 12 of of IN cord-005453-4057qib7 16037 13 a a DT cord-005453-4057qib7 16037 14 second second JJ cord-005453-4057qib7 16037 15 mobilization mobilization NN cord-005453-4057qib7 16037 16 and and CC cord-005453-4057qib7 16037 17 collection collection NN cord-005453-4057qib7 16037 18 of of IN cord-005453-4057qib7 16037 19 peripheral peripheral JJ cord-005453-4057qib7 16037 20 blood blood NN cord-005453-4057qib7 16037 21 stem stem NN cord-005453-4057qib7 16037 22 cells cell NNS cord-005453-4057qib7 16037 23 ( ( -LRB- cord-005453-4057qib7 16037 24 PBSC PBSC NNP cord-005453-4057qib7 16037 25 ) ) -RRB- cord-005453-4057qib7 16037 26 on on IN cord-005453-4057qib7 16037 27 the the DT cord-005453-4057qib7 16037 28 cell cell NN cord-005453-4057qib7 16037 29 yield yield NN cord-005453-4057qib7 16037 30 is be VBZ cord-005453-4057qib7 16037 31 low low JJ cord-005453-4057qib7 16037 32 , , , cord-005453-4057qib7 16037 33 as as IN cord-005453-4057qib7 16037 34 we -PRON- PRP cord-005453-4057qib7 16037 35 previously previously RB cord-005453-4057qib7 16037 36 demonstrated demonstrate VBD cord-005453-4057qib7 16037 37 . . . cord-005453-4057qib7 16038 1 However however RB cord-005453-4057qib7 16038 2 , , , cord-005453-4057qib7 16038 3 donor donor NN cord-005453-4057qib7 16038 4 safety safety NN cord-005453-4057qib7 16038 5 has have VBZ cord-005453-4057qib7 16038 6 been be VBN cord-005453-4057qib7 16038 7 poorly poorly RB cord-005453-4057qib7 16038 8 addressed address VBN cord-005453-4057qib7 16038 9 with with IN cord-005453-4057qib7 16038 10 no no DT cord-005453-4057qib7 16038 11 changes change NNS cord-005453-4057qib7 16038 12 in in IN cord-005453-4057qib7 16038 13 the the DT cord-005453-4057qib7 16038 14 clinical clinical JJ cord-005453-4057qib7 16038 15 practices practice NNS cord-005453-4057qib7 16038 16 . . . cord-005453-4057qib7 16039 1 Methods method NNS cord-005453-4057qib7 16039 2 : : : cord-005453-4057qib7 16039 3 Second second JJ cord-005453-4057qib7 16039 4 donations donation NNS cord-005453-4057qib7 16039 5 of of IN cord-005453-4057qib7 16039 6 unrelated unrelated JJ cord-005453-4057qib7 16039 7 and and CC cord-005453-4057qib7 16039 8 related related JJ cord-005453-4057qib7 16039 9 donors donor NNS cord-005453-4057qib7 16039 10 performed perform VBN cord-005453-4057qib7 16039 11 between between IN cord-005453-4057qib7 16039 12 2001 2001 CD cord-005453-4057qib7 16039 13 and and CC cord-005453-4057qib7 16039 14 2017 2017 CD cord-005453-4057qib7 16039 15 were be VBD cord-005453-4057qib7 16039 16 evaluated evaluate VBN cord-005453-4057qib7 16039 17 ( ( -LRB- cord-005453-4057qib7 16039 18 n=24 n=24 NNP cord-005453-4057qib7 16039 19 ) ) -RRB- cord-005453-4057qib7 16039 20 , , , cord-005453-4057qib7 16039 21 including include VBG cord-005453-4057qib7 16039 22 PBSC+PBSC PBSC+PBSC NNP cord-005453-4057qib7 16039 23 ( ( -LRB- cord-005453-4057qib7 16039 24 n=18 n=18 RB cord-005453-4057qib7 16039 25 ) ) -RRB- cord-005453-4057qib7 16039 26 , , , cord-005453-4057qib7 16039 27 bone bone NN cord-005453-4057qib7 16039 28 marrow marrow NN cord-005453-4057qib7 16039 29 ( ( -LRB- cord-005453-4057qib7 16039 30 BM)+PBSC BM)+PBSC NNP cord-005453-4057qib7 16039 31 ( ( -LRB- cord-005453-4057qib7 16039 32 n=5 n=5 NNP cord-005453-4057qib7 16039 33 ) ) -RRB- cord-005453-4057qib7 16039 34 and and CC cord-005453-4057qib7 16039 35 PBSC+BM PBSC+BM NNP cord-005453-4057qib7 16039 36 ( ( -LRB- cord-005453-4057qib7 16039 37 n=1 n=1 NN cord-005453-4057qib7 16039 38 ) ) -RRB- cord-005453-4057qib7 16039 39 . . . cord-005453-4057qib7 16040 1 Analytical analytical JJ cord-005453-4057qib7 16040 2 parameters parameter NNS cord-005453-4057qib7 16040 3 including include VBG cord-005453-4057qib7 16040 4 leukocyte leukocyte NN cord-005453-4057qib7 16040 5 , , , cord-005453-4057qib7 16040 6 lymphocyte lymphocyte NN cord-005453-4057qib7 16040 7 , , , cord-005453-4057qib7 16040 8 hemoglobin hemoglobin NN cord-005453-4057qib7 16040 9 and and CC cord-005453-4057qib7 16040 10 LDH LDH NNP cord-005453-4057qib7 16040 11 quantification quantification NN cord-005453-4057qib7 16040 12 , , , cord-005453-4057qib7 16040 13 obtained obtain VBN cord-005453-4057qib7 16040 14 on on IN cord-005453-4057qib7 16040 15 the the DT cord-005453-4057qib7 16040 16 pre pre JJ cord-005453-4057qib7 16040 17 - - JJ cord-005453-4057qib7 16040 18 harvest harvest JJ cord-005453-4057qib7 16040 19 evaluation evaluation NN cord-005453-4057qib7 16040 20 of of IN cord-005453-4057qib7 16040 21 first first JJ cord-005453-4057qib7 16040 22 and and CC cord-005453-4057qib7 16040 23 second second JJ cord-005453-4057qib7 16040 24 donation donation NN cord-005453-4057qib7 16040 25 , , , cord-005453-4057qib7 16040 26 were be VBD cord-005453-4057qib7 16040 27 retrospectively retrospectively RB cord-005453-4057qib7 16040 28 analyzed analyze VBN cord-005453-4057qib7 16040 29 and and CC cord-005453-4057qib7 16040 30 compared compare VBN cord-005453-4057qib7 16040 31 for for IN cord-005453-4057qib7 16040 32 all all DT cord-005453-4057qib7 16040 33 donors donor NNS cord-005453-4057qib7 16040 34 . . . cord-005453-4057qib7 16041 1 The the DT cord-005453-4057qib7 16041 2 Portuguese portuguese JJ cord-005453-4057qib7 16041 3 Bone Bone NNP cord-005453-4057qib7 16041 4 Marrow Marrow NNP cord-005453-4057qib7 16041 5 Donors donor NNS cord-005453-4057qib7 16041 6 Registry Registry NNP cord-005453-4057qib7 16041 7 ( ( -LRB- cord-005453-4057qib7 16041 8 CEDACE CEDACE NNP cord-005453-4057qib7 16041 9 ) ) -RRB- cord-005453-4057qib7 16041 10 recommends recommend VBZ cord-005453-4057qib7 16041 11 a a DT cord-005453-4057qib7 16041 12 time time NN cord-005453-4057qib7 16041 13 between between IN cord-005453-4057qib7 16041 14 donations donation NNS cord-005453-4057qib7 16041 15 no no DT cord-005453-4057qib7 16041 16 lesser less JJR cord-005453-4057qib7 16041 17 than than IN cord-005453-4057qib7 16041 18 6 6 CD cord-005453-4057qib7 16041 19 months month NNS cord-005453-4057qib7 16041 20 . . . cord-005453-4057qib7 16042 1 It -PRON- PRP cord-005453-4057qib7 16042 2 also also RB cord-005453-4057qib7 16042 3 states state VBZ cord-005453-4057qib7 16042 4 that that IN cord-005453-4057qib7 16042 5 in in IN cord-005453-4057qib7 16042 6 very very RB cord-005453-4057qib7 16042 7 urgent urgent JJ cord-005453-4057qib7 16042 8 situations situation NNS cord-005453-4057qib7 16042 9 like like IN cord-005453-4057qib7 16042 10 graft graft NN cord-005453-4057qib7 16042 11 failure failure NN cord-005453-4057qib7 16042 12 , , , cord-005453-4057qib7 16042 13 donor donor NN cord-005453-4057qib7 16042 14 should should MD cord-005453-4057qib7 16042 15 be be VB cord-005453-4057qib7 16042 16 clinical clinical JJ cord-005453-4057qib7 16042 17 and and CC cord-005453-4057qib7 16042 18 analytical analytical JJ cord-005453-4057qib7 16042 19 cleared clear VBN cord-005453-4057qib7 16042 20 and and CC cord-005453-4057qib7 16042 21 its -PRON- PRP$ cord-005453-4057qib7 16042 22 safety safety NN cord-005453-4057qib7 16042 23 ensured ensure VBD cord-005453-4057qib7 16042 24 . . . cord-005453-4057qib7 16043 1 In in IN cord-005453-4057qib7 16043 2 order order NN cord-005453-4057qib7 16043 3 to to TO cord-005453-4057qib7 16043 4 evaluate evaluate VB cord-005453-4057qib7 16043 5 the the DT cord-005453-4057qib7 16043 6 impact impact NN cord-005453-4057qib7 16043 7 of of IN cord-005453-4057qib7 16043 8 time time NN cord-005453-4057qib7 16043 9 between between IN cord-005453-4057qib7 16043 10 donations donation NNS cord-005453-4057qib7 16043 11 , , , cord-005453-4057qib7 16043 12 donor donor NN cord-005453-4057qib7 16043 13 population population NN cord-005453-4057qib7 16043 14 was be VBD cord-005453-4057qib7 16043 15 divided divide VBN cord-005453-4057qib7 16043 16 in in IN cord-005453-4057qib7 16043 17 3 3 CD cord-005453-4057qib7 16043 18 groups group NNS cord-005453-4057qib7 16043 19 : : : cord-005453-4057qib7 16043 20 < < XX cord-005453-4057qib7 16043 21 2 2 CD cord-005453-4057qib7 16043 22 months month NNS cord-005453-4057qib7 16043 23 , , , cord-005453-4057qib7 16043 24 2 2 CD cord-005453-4057qib7 16043 25 - - SYM cord-005453-4057qib7 16043 26 6 6 CD cord-005453-4057qib7 16043 27 months month NNS cord-005453-4057qib7 16043 28 , , , cord-005453-4057qib7 16043 29 > > XX cord-005453-4057qib7 16043 30 6 6 CD cord-005453-4057qib7 16043 31 months month NNS cord-005453-4057qib7 16043 32 ; ; : cord-005453-4057qib7 16043 33 to to TO cord-005453-4057qib7 16043 34 determine determine VB cord-005453-4057qib7 16043 35 the the DT cord-005453-4057qib7 16043 36 influence influence NN cord-005453-4057qib7 16043 37 of of IN cord-005453-4057qib7 16043 38 donor donor NN cord-005453-4057qib7 16043 39 age age NN cord-005453-4057qib7 16043 40 , , , cord-005453-4057qib7 16043 41 donors donor NNS cord-005453-4057qib7 16043 42 were be VBD cord-005453-4057qib7 16043 43 divided divide VBN cord-005453-4057qib7 16043 44 in in IN cord-005453-4057qib7 16043 45 2 2 CD cord-005453-4057qib7 16043 46 groups group NNS cord-005453-4057qib7 16043 47 : : : cord-005453-4057qib7 16043 48 < < XX cord-005453-4057qib7 16043 49 40 40 CD cord-005453-4057qib7 16043 50 and and CC cord-005453-4057qib7 16043 51 ≥40 ≥40 NNP cord-005453-4057qib7 16043 52 years year NNS cord-005453-4057qib7 16043 53 . . . cord-005453-4057qib7 16044 1 Results result NNS cord-005453-4057qib7 16044 2 : : : cord-005453-4057qib7 16045 1 Among among IN cord-005453-4057qib7 16045 2 the the DT cord-005453-4057qib7 16045 3 total total NN cord-005453-4057qib7 16045 4 of of IN cord-005453-4057qib7 16045 5 24 24 CD cord-005453-4057qib7 16045 6 donors donor NNS cord-005453-4057qib7 16045 7 , , , cord-005453-4057qib7 16045 8 13 13 CD cord-005453-4057qib7 16045 9 were be VBD cord-005453-4057qib7 16045 10 volunteer volunteer NN cord-005453-4057qib7 16045 11 donors donor NNS cord-005453-4057qib7 16045 12 of of IN cord-005453-4057qib7 16045 13 CEDACE CEDACE NNP cord-005453-4057qib7 16045 14 and and CC cord-005453-4057qib7 16045 15 11 11 CD cord-005453-4057qib7 16045 16 were be VBD cord-005453-4057qib7 16045 17 familiar familiar JJ cord-005453-4057qib7 16045 18 . . . cord-005453-4057qib7 16046 1 Fifteen fifteen CD cord-005453-4057qib7 16046 2 second second JJ cord-005453-4057qib7 16046 3 donations donation NNS cord-005453-4057qib7 16046 4 were be VBD cord-005453-4057qib7 16046 5 performed perform VBN cord-005453-4057qib7 16046 6 because because IN cord-005453-4057qib7 16046 7 of of IN cord-005453-4057qib7 16046 8 recipient recipient NN cord-005453-4057qib7 16046 9 graft graft NN cord-005453-4057qib7 16046 10 failure failure NN cord-005453-4057qib7 16046 11 and and CC cord-005453-4057qib7 16046 12 9 9 CD cord-005453-4057qib7 16046 13 due due IN cord-005453-4057qib7 16046 14 to to IN cord-005453-4057qib7 16046 15 disease disease NN cord-005453-4057qib7 16046 16 progression progression NN cord-005453-4057qib7 16046 17 or or CC cord-005453-4057qib7 16046 18 relapse relapse NN cord-005453-4057qib7 16046 19 . . . cord-005453-4057qib7 16047 1 At at IN cord-005453-4057qib7 16047 2 the the DT cord-005453-4057qib7 16047 3 time time NN cord-005453-4057qib7 16047 4 of of IN cord-005453-4057qib7 16047 5 second second JJ cord-005453-4057qib7 16047 6 collection collection NN cord-005453-4057qib7 16047 7 , , , cord-005453-4057qib7 16047 8 median median JJ cord-005453-4057qib7 16047 9 donor donor NN cord-005453-4057qib7 16047 10 age age NN cord-005453-4057qib7 16047 11 was be VBD cord-005453-4057qib7 16047 12 37 37 CD cord-005453-4057qib7 16047 13 years year NNS cord-005453-4057qib7 16048 1 ( ( -LRB- cord-005453-4057qib7 16048 2 range range NNP cord-005453-4057qib7 16048 3 23 23 CD cord-005453-4057qib7 16048 4 - - SYM cord-005453-4057qib7 16048 5 57 57 CD cord-005453-4057qib7 16048 6 ) ) -RRB- cord-005453-4057qib7 16048 7 . . . cord-005453-4057qib7 16049 1 The the DT cord-005453-4057qib7 16049 2 median median JJ cord-005453-4057qib7 16049 3 delay delay NN cord-005453-4057qib7 16049 4 between between IN cord-005453-4057qib7 16049 5 both both DT cord-005453-4057qib7 16049 6 collections collection NNS cord-005453-4057qib7 16049 7 was be VBD cord-005453-4057qib7 16049 8 262 262 CD cord-005453-4057qib7 16049 9 days day NNS cord-005453-4057qib7 16049 10 ( ( -LRB- cord-005453-4057qib7 16049 11 37 37 CD cord-005453-4057qib7 16049 12 - - SYM cord-005453-4057qib7 16049 13 1519 1519 CD cord-005453-4057qib7 16049 14 ) ) -RRB- cord-005453-4057qib7 16049 15 . . . cord-005453-4057qib7 16050 1 Time time NN cord-005453-4057qib7 16050 2 between between IN cord-005453-4057qib7 16050 3 donations donation NNS cord-005453-4057qib7 16050 4 did do VBD cord-005453-4057qib7 16050 5 not not RB cord-005453-4057qib7 16050 6 seem seem VB cord-005453-4057qib7 16050 7 to to TO cord-005453-4057qib7 16050 8 substantially substantially RB cord-005453-4057qib7 16050 9 impact impact VB cord-005453-4057qib7 16050 10 the the DT cord-005453-4057qib7 16050 11 analytical analytical JJ cord-005453-4057qib7 16050 12 donor donor NN cord-005453-4057qib7 16050 13 evaluation evaluation NN cord-005453-4057qib7 16050 14 : : : cord-005453-4057qib7 16050 15 leukocytes leukocyte NNS cord-005453-4057qib7 16050 16 , , , cord-005453-4057qib7 16050 17 lymphocytes lymphocyte NNS cord-005453-4057qib7 16050 18 , , , cord-005453-4057qib7 16050 19 hemoglobin hemoglobin NN cord-005453-4057qib7 16050 20 and and CC cord-005453-4057qib7 16050 21 LDH LDH NNP cord-005453-4057qib7 16050 22 results result NNS cord-005453-4057qib7 16050 23 are be VBP cord-005453-4057qib7 16050 24 kept keep VBN cord-005453-4057qib7 16050 25 within within IN cord-005453-4057qib7 16050 26 the the DT cord-005453-4057qib7 16050 27 reference reference NN cord-005453-4057qib7 16050 28 values value NNS cord-005453-4057qib7 16050 29 . . . cord-005453-4057qib7 16051 1 However however RB cord-005453-4057qib7 16051 2 , , , cord-005453-4057qib7 16051 3 donors donor NNS cord-005453-4057qib7 16051 4 with with IN cord-005453-4057qib7 16051 5 less less JJR cord-005453-4057qib7 16051 6 than than IN cord-005453-4057qib7 16051 7 2 2 CD cord-005453-4057qib7 16051 8 months month NNS cord-005453-4057qib7 16051 9 between between IN cord-005453-4057qib7 16051 10 donations donation NNS cord-005453-4057qib7 16051 11 showed show VBD cord-005453-4057qib7 16051 12 a a DT cord-005453-4057qib7 16051 13 slight slight JJ cord-005453-4057qib7 16051 14 decrease decrease NN cord-005453-4057qib7 16051 15 on on IN cord-005453-4057qib7 16051 16 leukocyte leukocyte NN cord-005453-4057qib7 16051 17 counts count NNS cord-005453-4057qib7 16051 18 ( ( -LRB- cord-005453-4057qib7 16051 19 35 35 CD cord-005453-4057qib7 16051 20 % % NN cord-005453-4057qib7 16051 21 ) ) -RRB- cord-005453-4057qib7 16051 22 and and CC cord-005453-4057qib7 16051 23 hemoglobin hemoglobin NN cord-005453-4057qib7 16051 24 values value NNS cord-005453-4057qib7 16051 25 ( ( -LRB- cord-005453-4057qib7 16051 26 12 12 CD cord-005453-4057qib7 16051 27 % % NN cord-005453-4057qib7 16051 28 ) ) -RRB- cord-005453-4057qib7 16051 29 , , , cord-005453-4057qib7 16051 30 from from IN cord-005453-4057qib7 16051 31 the the DT cord-005453-4057qib7 16051 32 first first JJ cord-005453-4057qib7 16051 33 to to IN cord-005453-4057qib7 16051 34 the the DT cord-005453-4057qib7 16051 35 second second JJ cord-005453-4057qib7 16051 36 pre pre JJ cord-005453-4057qib7 16051 37 - - JJ cord-005453-4057qib7 16051 38 harvest harvest JJ cord-005453-4057qib7 16051 39 evaluation evaluation NN cord-005453-4057qib7 16051 40 . . . cord-005453-4057qib7 16052 1 Donor donor NN cord-005453-4057qib7 16052 2 age age NN cord-005453-4057qib7 16052 3 showed show VBD cord-005453-4057qib7 16052 4 no no DT cord-005453-4057qib7 16052 5 significant significant JJ cord-005453-4057qib7 16052 6 influence influence NN cord-005453-4057qib7 16052 7 on on IN cord-005453-4057qib7 16052 8 the the DT cord-005453-4057qib7 16052 9 analytical analytical JJ cord-005453-4057qib7 16052 10 evaluation evaluation NN cord-005453-4057qib7 16052 11 . . . cord-005453-4057qib7 16053 1 Nevertheless nevertheless RB cord-005453-4057qib7 16053 2 , , , cord-005453-4057qib7 16053 3 when when WRB cord-005453-4057qib7 16053 4 considering consider VBG cord-005453-4057qib7 16053 5 only only RB cord-005453-4057qib7 16053 6 the the DT cord-005453-4057qib7 16053 7 PBSC+PBSC PBSC+PBSC NNP cord-005453-4057qib7 16053 8 donations donation NNS cord-005453-4057qib7 16053 9 , , , cord-005453-4057qib7 16053 10 donors donor NNS cord-005453-4057qib7 16053 11 with with IN cord-005453-4057qib7 16053 12 ≥40 ≥40 NNP cord-005453-4057qib7 16053 13 years year NNS cord-005453-4057qib7 16053 14 showed show VBD cord-005453-4057qib7 16053 15 a a DT cord-005453-4057qib7 16053 16 small small JJ cord-005453-4057qib7 16053 17 decrease decrease NN cord-005453-4057qib7 16053 18 on on IN cord-005453-4057qib7 16053 19 lymphocyte lymphocyte NN cord-005453-4057qib7 16053 20 counts count NNS cord-005453-4057qib7 16053 21 ( ( -LRB- cord-005453-4057qib7 16053 22 19 19 CD cord-005453-4057qib7 16053 23 % % NN cord-005453-4057qib7 16053 24 ) ) -RRB- cord-005453-4057qib7 16054 1 .Conclusions .conclusion NNS cord-005453-4057qib7 16054 2 : : : cord-005453-4057qib7 16055 1 This this DT cord-005453-4057qib7 16055 2 study study NN cord-005453-4057qib7 16055 3 demonstrated demonstrate VBD cord-005453-4057qib7 16055 4 that that IN cord-005453-4057qib7 16055 5 the the DT cord-005453-4057qib7 16055 6 analytical analytical JJ cord-005453-4057qib7 16055 7 parameters parameter NNS cord-005453-4057qib7 16055 8 , , , cord-005453-4057qib7 16055 9 chosen choose VBN cord-005453-4057qib7 16055 10 based base VBN cord-005453-4057qib7 16055 11 on on IN cord-005453-4057qib7 16055 12 literature literature NN cord-005453-4057qib7 16055 13 , , , cord-005453-4057qib7 16055 14 had have VBD cord-005453-4057qib7 16055 15 no no DT cord-005453-4057qib7 16055 16 significant significant JJ cord-005453-4057qib7 16055 17 changes change NNS cord-005453-4057qib7 16055 18 between between IN cord-005453-4057qib7 16055 19 first first JJ cord-005453-4057qib7 16055 20 and and CC cord-005453-4057qib7 16055 21 second second JJ cord-005453-4057qib7 16055 22 donation donation NN cord-005453-4057qib7 16055 23 . . . cord-005453-4057qib7 16056 1 However however RB cord-005453-4057qib7 16056 2 , , , cord-005453-4057qib7 16056 3 particular particular JJ cord-005453-4057qib7 16056 4 attention attention NN cord-005453-4057qib7 16056 5 should should MD cord-005453-4057qib7 16056 6 be be VB cord-005453-4057qib7 16056 7 paid pay VBN cord-005453-4057qib7 16056 8 when when WRB cord-005453-4057qib7 16056 9 time time NN cord-005453-4057qib7 16056 10 between between IN cord-005453-4057qib7 16056 11 donations donation NNS cord-005453-4057qib7 16056 12 is be VBZ cord-005453-4057qib7 16056 13 lesser less JJR cord-005453-4057qib7 16056 14 than than IN cord-005453-4057qib7 16056 15 2 2 CD cord-005453-4057qib7 16056 16 months month NNS cord-005453-4057qib7 16056 17 or or CC cord-005453-4057qib7 16056 18 donor donor NN cord-005453-4057qib7 16056 19 age age NN cord-005453-4057qib7 16056 20 is be VBZ cord-005453-4057qib7 16056 21 ≥40 ≥40 NNP cord-005453-4057qib7 16056 22 years year NNS cord-005453-4057qib7 16056 23 . . . cord-005453-4057qib7 16057 1 As as IN cord-005453-4057qib7 16057 2 we -PRON- PRP cord-005453-4057qib7 16057 3 concluded conclude VBD cord-005453-4057qib7 16057 4 that that IN cord-005453-4057qib7 16057 5 no no DT cord-005453-4057qib7 16057 6 significant significant JJ cord-005453-4057qib7 16057 7 changes change NNS cord-005453-4057qib7 16057 8 were be VBD cord-005453-4057qib7 16057 9 observed observe VBN cord-005453-4057qib7 16057 10 in in IN cord-005453-4057qib7 16057 11 the the DT cord-005453-4057qib7 16057 12 group group NN cord-005453-4057qib7 16057 13 of of IN cord-005453-4057qib7 16057 14 2 2 CD cord-005453-4057qib7 16057 15 - - SYM cord-005453-4057qib7 16057 16 6 6 CD cord-005453-4057qib7 16057 17 months month NNS cord-005453-4057qib7 16057 18 , , , cord-005453-4057qib7 16057 19 it -PRON- PRP cord-005453-4057qib7 16057 20 is be VBZ cord-005453-4057qib7 16057 21 our -PRON- PRP$ cord-005453-4057qib7 16057 22 opinion opinion NN cord-005453-4057qib7 16057 23 that that IN cord-005453-4057qib7 16057 24 the the DT cord-005453-4057qib7 16057 25 minimum minimum NN cord-005453-4057qib7 16057 26 of of IN cord-005453-4057qib7 16057 27 6 6 CD cord-005453-4057qib7 16057 28 - - SYM cord-005453-4057qib7 16057 29 12 12 CD cord-005453-4057qib7 16057 30 months month NNS cord-005453-4057qib7 16057 31 established establish VBN cord-005453-4057qib7 16057 32 by by IN cord-005453-4057qib7 16057 33 the the DT cord-005453-4057qib7 16057 34 registries registry NNS cord-005453-4057qib7 16057 35 can can MD cord-005453-4057qib7 16057 36 be be VB cord-005453-4057qib7 16057 37 shortened shorten VBN cord-005453-4057qib7 16057 38 to to IN cord-005453-4057qib7 16057 39 2 2 CD cord-005453-4057qib7 16057 40 months month NNS cord-005453-4057qib7 16057 41 ensuring ensure VBG cord-005453-4057qib7 16057 42 donor donor NN cord-005453-4057qib7 16057 43 safety safety NN cord-005453-4057qib7 16057 44 . . . cord-005453-4057qib7 16058 1 An an DT cord-005453-4057qib7 16058 2 accurate accurate JJ cord-005453-4057qib7 16058 3 donor donor NN cord-005453-4057qib7 16058 4 risk risk NN cord-005453-4057qib7 16058 5 assessment assessment NN cord-005453-4057qib7 16058 6 with with IN cord-005453-4057qib7 16058 7 a a DT cord-005453-4057qib7 16058 8 larger large JJR cord-005453-4057qib7 16058 9 population population NN cord-005453-4057qib7 16058 10 should should MD cord-005453-4057qib7 16058 11 be be VB cord-005453-4057qib7 16058 12 accomplished accomplish VBN cord-005453-4057qib7 16058 13 in in IN cord-005453-4057qib7 16058 14 order order NN cord-005453-4057qib7 16058 15 to to TO cord-005453-4057qib7 16058 16 strengthen strengthen VB cord-005453-4057qib7 16058 17 this this DT cord-005453-4057qib7 16058 18 recommendation recommendation NN cord-005453-4057qib7 16058 19 . . . cord-005453-4057qib7 16059 1 Disclosure disclosure NN cord-005453-4057qib7 16059 2 : : : cord-005453-4057qib7 16059 3 Nothing nothing NN cord-005453-4057qib7 16059 4 to to TO cord-005453-4057qib7 16059 5 declare declare VB cord-005453-4057qib7 16059 6 . . . cord-005453-4057qib7 16060 1 Gaurav Gaurav NNP cord-005453-4057qib7 16060 2 Kharya Kharya NNP cord-005453-4057qib7 16060 3 1 1 CD cord-005453-4057qib7 16060 4 , , , cord-005453-4057qib7 16060 5 Atish Atish NNP cord-005453-4057qib7 16060 6 Bakane Bakane NNP cord-005453-4057qib7 16060 7 1 1 CD cord-005453-4057qib7 16060 8 , , , cord-005453-4057qib7 16060 9 Pratibha Pratibha NNP cord-005453-4057qib7 16060 10 Dhiman Dhiman NNP cord-005453-4057qib7 16060 11 1 1 CD cord-005453-4057qib7 16060 12 , , , cord-005453-4057qib7 16060 13 Anil Anil NNP cord-005453-4057qib7 16060 14 Khetrapal Khetrapal NNP cord-005453-4057qib7 16060 15 1 1 CD cord-005453-4057qib7 16060 16 , , , cord-005453-4057qib7 16060 17 Vikrant Vikrant NNP cord-005453-4057qib7 16060 18 Bhar Bhar NNP cord-005453-4057qib7 16061 1 1 1 CD cord-005453-4057qib7 16061 2 Background background NN cord-005453-4057qib7 16061 3 : : : cord-005453-4057qib7 16061 4 T t NN cord-005453-4057qib7 16061 5 cell cell NN cord-005453-4057qib7 16061 6 replete replete JJ cord-005453-4057qib7 16061 7 haploidentical haploidentical JJ cord-005453-4057qib7 16061 8 stem stem NN cord-005453-4057qib7 16061 9 cell cell NN cord-005453-4057qib7 16061 10 transplant transplant NN cord-005453-4057qib7 16061 11 ( ( -LRB- cord-005453-4057qib7 16061 12 HHSCT HHSCT NNP cord-005453-4057qib7 16061 13 ) ) -RRB- cord-005453-4057qib7 16061 14 is be VBZ cord-005453-4057qib7 16061 15 complicated complicate VBN cord-005453-4057qib7 16061 16 mainly mainly RB cord-005453-4057qib7 16061 17 by by IN cord-005453-4057qib7 16061 18 increased increase VBN cord-005453-4057qib7 16061 19 risk risk NN cord-005453-4057qib7 16061 20 of of IN cord-005453-4057qib7 16061 21 graft graft NN cord-005453-4057qib7 16061 22 failure failure NN cord-005453-4057qib7 16061 23 ( ( -LRB- cord-005453-4057qib7 16061 24 GF GF NNP cord-005453-4057qib7 16061 25 ) ) -RRB- cord-005453-4057qib7 16061 26 and and CC cord-005453-4057qib7 16061 27 graft graft NN cord-005453-4057qib7 16061 28 versus versus IN cord-005453-4057qib7 16061 29 host host NN cord-005453-4057qib7 16061 30 disease disease NN cord-005453-4057qib7 16061 31 ( ( -LRB- cord-005453-4057qib7 16061 32 GVHD GVHD NNP cord-005453-4057qib7 16061 33 ) ) -RRB- cord-005453-4057qib7 16061 34 . . . cord-005453-4057qib7 16062 1 Conventionally conventionally RB cord-005453-4057qib7 16062 2 GCSF GCSF NNP cord-005453-4057qib7 16062 3 has have VBZ cord-005453-4057qib7 16062 4 been be VBN cord-005453-4057qib7 16062 5 used use VBN cord-005453-4057qib7 16062 6 to to TO cord-005453-4057qib7 16062 7 mobilize mobilize VB cord-005453-4057qib7 16062 8 hematopoietic hematopoietic JJ cord-005453-4057qib7 16062 9 stem stem NN cord-005453-4057qib7 16062 10 cells cell NNS cord-005453-4057qib7 16062 11 ( ( -LRB- cord-005453-4057qib7 16062 12 HSC HSC NNP cord-005453-4057qib7 16062 13 ) ) -RRB- cord-005453-4057qib7 16062 14 . . . cord-005453-4057qib7 16063 1 In in IN cord-005453-4057qib7 16063 2 TCR TCR NNP cord-005453-4057qib7 16063 3 HHSCT HHSCT NNP cord-005453-4057qib7 16063 4 GCSF GCSF NNP cord-005453-4057qib7 16063 5 mobilized mobilize VBD cord-005453-4057qib7 16063 6 graft graft NN cord-005453-4057qib7 16063 7 with with IN cord-005453-4057qib7 16063 8 megadose megadose NN cord-005453-4057qib7 16063 9 of of IN cord-005453-4057qib7 16063 10 CD34 CD34 NNP cord-005453-4057qib7 16063 11 + + CC cord-005453-4057qib7 16063 12 cells cell NNS cord-005453-4057qib7 16063 13 expose expose VBP cord-005453-4057qib7 16063 14 the the DT cord-005453-4057qib7 16063 15 patient patient NN cord-005453-4057qib7 16063 16 to to IN cord-005453-4057qib7 16063 17 higher high JJR cord-005453-4057qib7 16063 18 doses dose NNS cord-005453-4057qib7 16063 19 of of IN cord-005453-4057qib7 16063 20 alloreactive alloreactive JJ cord-005453-4057qib7 16063 21 T T NNP cord-005453-4057qib7 16063 22 cells cell NNS cord-005453-4057qib7 16063 23 increasing increase VBG cord-005453-4057qib7 16063 24 the the DT cord-005453-4057qib7 16063 25 risk risk NN cord-005453-4057qib7 16063 26 of of IN cord-005453-4057qib7 16063 27 GVHD GVHD NNP cord-005453-4057qib7 16063 28 . . . cord-005453-4057qib7 16064 1 Plerixafor Plerixafor NNP cord-005453-4057qib7 16064 2 based base VBN cord-005453-4057qib7 16064 3 mobilization mobilization NN cord-005453-4057qib7 16064 4 gives give VBZ cord-005453-4057qib7 16064 5 an an DT cord-005453-4057qib7 16064 6 advantage advantage NN cord-005453-4057qib7 16064 7 of of IN cord-005453-4057qib7 16064 8 giving give VBG cord-005453-4057qib7 16064 9 high high JJ cord-005453-4057qib7 16064 10 CD34 CD34 NNP cord-005453-4057qib7 16064 11 cell cell NN cord-005453-4057qib7 16064 12 dose dose NN cord-005453-4057qib7 16064 13 limiting limit VBG cord-005453-4057qib7 16064 14 exposure exposure NN cord-005453-4057qib7 16064 15 to to IN cord-005453-4057qib7 16064 16 high high JJ cord-005453-4057qib7 16064 17 alloreactive alloreactive JJ cord-005453-4057qib7 16064 18 T T NNP cord-005453-4057qib7 16064 19 cell cell NN cord-005453-4057qib7 16064 20 dose dose NN cord-005453-4057qib7 16064 21 . . . cord-005453-4057qib7 16065 1 We -PRON- PRP cord-005453-4057qib7 16065 2 share share VBP cord-005453-4057qib7 16065 3 our -PRON- PRP$ cord-005453-4057qib7 16065 4 experience experience NN cord-005453-4057qib7 16065 5 of of IN cord-005453-4057qib7 16065 6 GCSF GCSF NNP cord-005453-4057qib7 16065 7 + + CC cord-005453-4057qib7 16065 8 Plerixafor Plerixafor NNP cord-005453-4057qib7 16065 9 based base VBN cord-005453-4057qib7 16065 10 mobilization mobilization NN cord-005453-4057qib7 16065 11 for for IN cord-005453-4057qib7 16065 12 TCR TCR NNP cord-005453-4057qib7 16065 13 HHSCT HHSCT NNP cord-005453-4057qib7 16065 14 . . . cord-005453-4057qib7 16066 1 Methods method NNS cord-005453-4057qib7 16066 2 : : : cord-005453-4057qib7 16066 3 9 9 CD cord-005453-4057qib7 16066 4 consecutive consecutive JJ cord-005453-4057qib7 16066 5 patients patient NNS cord-005453-4057qib7 16066 6 suffering suffer VBG cord-005453-4057qib7 16066 7 from from IN cord-005453-4057qib7 16066 8 SCD SCD NNP cord-005453-4057qib7 16066 9 who who WP cord-005453-4057qib7 16066 10 underwent undergo VBD cord-005453-4057qib7 16066 11 HHSCT HHSCT NNP cord-005453-4057qib7 16066 12 between between IN cord-005453-4057qib7 16066 13 Jan Jan NNP cord-005453-4057qib7 16066 14 2018 2018 CD cord-005453-4057qib7 16066 15 till till IN cord-005453-4057qib7 16066 16 date date NN cord-005453-4057qib7 16066 17 along along IN cord-005453-4057qib7 16066 18 with with IN cord-005453-4057qib7 16066 19 the the DT cord-005453-4057qib7 16066 20 respective respective JJ cord-005453-4057qib7 16066 21 donors donor NNS cord-005453-4057qib7 16066 22 were be VBD cord-005453-4057qib7 16066 23 enrolled enrol VBN cord-005453-4057qib7 16066 24 in in IN cord-005453-4057qib7 16066 25 the the DT cord-005453-4057qib7 16066 26 study study NN cord-005453-4057qib7 16066 27 ( ( -LRB- cord-005453-4057qib7 16066 28 Group Group NNP cord-005453-4057qib7 16066 29 1 1 CD cord-005453-4057qib7 16066 30 ) ) -RRB- cord-005453-4057qib7 16066 31 . . . cord-005453-4057qib7 16067 1 All all DT cord-005453-4057qib7 16067 2 9 9 CD cord-005453-4057qib7 16067 3 underwent undergo VBD cord-005453-4057qib7 16067 4 pre pre JJ cord-005453-4057qib7 16067 5 - - JJ cord-005453-4057qib7 16067 6 transplant transplant JJ cord-005453-4057qib7 16067 7 immune immune JJ cord-005453-4057qib7 16067 8 suppression suppression NN cord-005453-4057qib7 16067 9 ( ( -LRB- cord-005453-4057qib7 16067 10 PTIS PTIS NNP cord-005453-4057qib7 16067 11 ) ) -RRB- cord-005453-4057qib7 16067 12 2 2 CD cord-005453-4057qib7 16067 13 cycles cycle NNS cord-005453-4057qib7 16067 14 at at IN cord-005453-4057qib7 16067 15 3 3 CD cord-005453-4057qib7 16067 16 weekly weekly JJ cord-005453-4057qib7 16067 17 intervals interval NNS cord-005453-4057qib7 16067 18 using use VBG cord-005453-4057qib7 16067 19 fludarabine+cyclophosphamide+dexamethasone fludarabine+cyclophosphamide+dexamethasone NNP cord-005453-4057qib7 16067 20 . . . cord-005453-4057qib7 16068 1 The the DT cord-005453-4057qib7 16068 2 graft graft NN cord-005453-4057qib7 16068 3 was be VBD cord-005453-4057qib7 16068 4 mobilized mobilize VBN cord-005453-4057qib7 16068 5 using use VBG cord-005453-4057qib7 16068 6 GCSF@10mcg GCSF@10mcg NNP cord-005453-4057qib7 16068 7 / / SYM cord-005453-4057qib7 16068 8 kg kg NNP cord-005453-4057qib7 16068 9 / / SYM cord-005453-4057qib7 16068 10 day(D1-D5)+plerixafor@0.24mg day(D1-D5)+plerixafor@0.24mg NNS cord-005453-4057qib7 16068 11 / / SYM cord-005453-4057qib7 16068 12 kg(D5 kg(D5 NNP cord-005453-4057qib7 16068 13 ) ) -RRB- cord-005453-4057qib7 16069 1 6 6 CD cord-005453-4057qib7 16069 2 - - SYM cord-005453-4057qib7 16069 3 8 8 CD cord-005453-4057qib7 16069 4 hours hour NNS cord-005453-4057qib7 16069 5 before before IN cord-005453-4057qib7 16069 6 the the DT cord-005453-4057qib7 16069 7 PBSCH PBSCH NNP cord-005453-4057qib7 16069 8 . . . cord-005453-4057qib7 16070 1 GVHD GVHD NNP cord-005453-4057qib7 16070 2 prophylaxis prophylaxis NN cord-005453-4057qib7 16070 3 included include VBD cord-005453-4057qib7 16070 4 PTCy PTCy NNS cord-005453-4057qib7 16070 5 50 50 CD cord-005453-4057qib7 16070 6 mg mg NNP cord-005453-4057qib7 16070 7 / / SYM cord-005453-4057qib7 16070 8 kg/ kg/ NNP cord-005453-4057qib7 16070 9 day day NN cord-005453-4057qib7 16070 10 on on IN cord-005453-4057qib7 16070 11 D3 D3 NNP cord-005453-4057qib7 16070 12 and and CC cord-005453-4057qib7 16070 13 4 4 CD cord-005453-4057qib7 16070 14 , , , cord-005453-4057qib7 16070 15 sirolimus sirolimus NN cord-005453-4057qib7 16070 16 and and CC cord-005453-4057qib7 16070 17 MMF mmf NN cord-005453-4057qib7 16070 18 starting start VBG cord-005453-4057qib7 16070 19 from from IN cord-005453-4057qib7 16070 20 D5 D5 NNP cord-005453-4057qib7 16070 21 . . . cord-005453-4057qib7 16071 1 Group group NN cord-005453-4057qib7 16071 2 2 2 CD cord-005453-4057qib7 16071 3 included include VBD cord-005453-4057qib7 16071 4 5 5 CD cord-005453-4057qib7 16071 5 historical historical JJ cord-005453-4057qib7 16071 6 controls control NNS cord-005453-4057qib7 16071 7 where where WRB cord-005453-4057qib7 16071 8 graft graft NN cord-005453-4057qib7 16071 9 was be VBD cord-005453-4057qib7 16071 10 mobilized mobilize VBN cord-005453-4057qib7 16071 11 using use VBG cord-005453-4057qib7 16071 12 GCSF@10mcg GCSF@10mcg NNP cord-005453-4057qib7 16071 13 / / SYM cord-005453-4057qib7 16071 14 kg kg NN cord-005453-4057qib7 16071 15 / / SYM cord-005453-4057qib7 16071 16 day(D1-D5 day(d1-d5 NN cord-005453-4057qib7 16071 17 ) ) -RRB- cord-005453-4057qib7 16071 18 . . . cord-005453-4057qib7 16072 1 Various various JJ cord-005453-4057qib7 16072 2 parameters parameter NNS cord-005453-4057qib7 16072 3 pertaining pertain VBG cord-005453-4057qib7 16072 4 to to IN cord-005453-4057qib7 16072 5 mobilization mobilization NN cord-005453-4057qib7 16072 6 , , , cord-005453-4057qib7 16072 7 harvest harvest NN cord-005453-4057qib7 16072 8 , , , cord-005453-4057qib7 16072 9 engraftment engraftment NN cord-005453-4057qib7 16072 10 , , , cord-005453-4057qib7 16072 11 GF GF NNP cord-005453-4057qib7 16072 12 and and CC cord-005453-4057qib7 16072 13 GVHD GVHD NNP cord-005453-4057qib7 16072 14 were be VBD cord-005453-4057qib7 16072 15 assessed assess VBN cord-005453-4057qib7 16072 16 between between IN cord-005453-4057qib7 16072 17 the the DT cord-005453-4057qib7 16072 18 two two CD cord-005453-4057qib7 16072 19 groups group NNS cord-005453-4057qib7 16072 20 . . . cord-005453-4057qib7 16073 1 Background background NN cord-005453-4057qib7 16073 2 : : : cord-005453-4057qib7 16074 1 Poor poor JJ cord-005453-4057qib7 16074 2 mobilizers mobilizer NNS cord-005453-4057qib7 16074 3 ( ( -LRB- cord-005453-4057qib7 16074 4 PM pm NN cord-005453-4057qib7 16074 5 ) ) -RRB- cord-005453-4057qib7 16074 6 defined define VBN cord-005453-4057qib7 16074 7 as as IN cord-005453-4057qib7 16074 8 those those DT cord-005453-4057qib7 16074 9 with with IN cord-005453-4057qib7 16074 10 a a DT cord-005453-4057qib7 16074 11 peripheral peripheral JJ cord-005453-4057qib7 16074 12 blood blood NN cord-005453-4057qib7 16074 13 CD34 CD34 NNP cord-005453-4057qib7 16075 1 + + CC cord-005453-4057qib7 16075 2 count count VB cord-005453-4057qib7 16075 3 ≤10cells/ ≤10cells/ NNP cord-005453-4057qib7 16076 1 μl μl RB cord-005453-4057qib7 16076 2 on on IN cord-005453-4057qib7 16076 3 day+4 day+4 NNP cord-005453-4057qib7 16076 4 is be VBZ cord-005453-4057qib7 16076 5 a a DT cord-005453-4057qib7 16076 6 significant significant JJ cord-005453-4057qib7 16076 7 risk risk NN cord-005453-4057qib7 16076 8 factor factor NN cord-005453-4057qib7 16076 9 for for IN cord-005453-4057qib7 16076 10 mobilization mobilization NN cord-005453-4057qib7 16076 11 failure failure NN cord-005453-4057qib7 16076 12 . . . cord-005453-4057qib7 16077 1 Within within IN cord-005453-4057qib7 16077 2 these these DT cord-005453-4057qib7 16077 3 , , , cord-005453-4057qib7 16077 4 patients patient NNS cord-005453-4057qib7 16077 5 with with IN cord-005453-4057qib7 16077 6 < < XX cord-005453-4057qib7 16077 7 5cells 5cells CD cord-005453-4057qib7 16078 1 /μl /μl : cord-005453-4057qib7 16078 2 are be VBP cord-005453-4057qib7 16078 3 considered consider VBN cord-005453-4057qib7 16078 4 as as IN cord-005453-4057qib7 16078 5 very very RB cord-005453-4057qib7 16078 6 poor poor JJ cord-005453-4057qib7 16078 7 mobilizers mobilizer NNS cord-005453-4057qib7 16078 8 ( ( -LRB- cord-005453-4057qib7 16078 9 VPM VPM NNP cord-005453-4057qib7 16078 10 ) ) -RRB- cord-005453-4057qib7 16078 11 . . . cord-005453-4057qib7 16079 1 Use use NN cord-005453-4057qib7 16079 2 of of IN cord-005453-4057qib7 16079 3 plerixafor plerixafor NN cord-005453-4057qib7 16079 4 in in IN cord-005453-4057qib7 16079 5 VPM VPM NNP cord-005453-4057qib7 16079 6 patient patient NN cord-005453-4057qib7 16079 7 is be VBZ cord-005453-4057qib7 16079 8 controversial controversial JJ cord-005453-4057qib7 16079 9 . . . cord-005453-4057qib7 16080 1 The the DT cord-005453-4057qib7 16080 2 aim aim NN cord-005453-4057qib7 16080 3 of of IN cord-005453-4057qib7 16080 4 our -PRON- PRP$ cord-005453-4057qib7 16080 5 study study NN cord-005453-4057qib7 16080 6 is be VBZ cord-005453-4057qib7 16080 7 to to TO cord-005453-4057qib7 16080 8 compare compare VB cord-005453-4057qib7 16080 9 mobilizing mobilizing NN cord-005453-4057qib7 16080 10 and and CC cord-005453-4057qib7 16080 11 engraftment engraftment NN cord-005453-4057qib7 16080 12 between between IN cord-005453-4057qib7 16080 13 PM PM NNP cord-005453-4057qib7 16080 14 and and CC cord-005453-4057qib7 16080 15 VPM VPM NNP cord-005453-4057qib7 16080 16 who who WP cord-005453-4057qib7 16080 17 received receive VBD cord-005453-4057qib7 16080 18 Plerixafor Plerixafor NNP cord-005453-4057qib7 16080 19 plus plus CC cord-005453-4057qib7 16080 20 G G NNP cord-005453-4057qib7 16080 21 - - HYPH cord-005453-4057qib7 16080 22 CSF CSF NNP cord-005453-4057qib7 16080 23 ( ( -LRB- cord-005453-4057qib7 16080 24 P+G P+G NNP cord-005453-4057qib7 16080 25 - - HYPH cord-005453-4057qib7 16080 26 CSF).Methods CSF).Methods NNP cord-005453-4057qib7 16080 27 : : : cord-005453-4057qib7 16081 1 In in IN cord-005453-4057qib7 16081 2 our -PRON- PRP$ cord-005453-4057qib7 16081 3 center center NN cord-005453-4057qib7 16081 4 , , , cord-005453-4057qib7 16081 5 mobilization mobilization NN cord-005453-4057qib7 16081 6 with with IN cord-005453-4057qib7 16081 7 G G NNP cord-005453-4057qib7 16081 8 - - HYPH cord-005453-4057qib7 16081 9 CSF CSF NNP cord-005453-4057qib7 16081 10 at at IN cord-005453-4057qib7 16081 11 dose dose NN cord-005453-4057qib7 16081 12 of of IN cord-005453-4057qib7 16081 13 10μg 10μg CD cord-005453-4057qib7 16081 14 / / SYM cord-005453-4057qib7 16081 15 Kg Kg NNP cord-005453-4057qib7 16081 16 / / SYM cord-005453-4057qib7 16081 17 day day NN cord-005453-4057qib7 16081 18 was be VBD cord-005453-4057qib7 16081 19 used use VBN cord-005453-4057qib7 16081 20 in in IN cord-005453-4057qib7 16081 21 all all DT cord-005453-4057qib7 16081 22 pts pt NNS cord-005453-4057qib7 16081 23 . . . cord-005453-4057qib7 16082 1 Apheresis Apheresis NNP cord-005453-4057qib7 16082 2 were be VBD cord-005453-4057qib7 16082 3 scheduled schedule VBN cord-005453-4057qib7 16082 4 on on IN cord-005453-4057qib7 16082 5 day+5 day+5 NN cord-005453-4057qib7 16082 6 . . . cord-005453-4057qib7 16083 1 Plerixafor Plerixafor NNP cord-005453-4057qib7 16083 2 ( ( -LRB- cord-005453-4057qib7 16083 3 0.24 0.24 CD cord-005453-4057qib7 16083 4 mg mg NNP cord-005453-4057qib7 16083 5 / / SYM cord-005453-4057qib7 16083 6 kg kg NNP cord-005453-4057qib7 16083 7 ) ) -RRB- cord-005453-4057qib7 16083 8 was be VBD cord-005453-4057qib7 16083 9 added add VBN cord-005453-4057qib7 16083 10 if if IN cord-005453-4057qib7 16083 11 the the DT cord-005453-4057qib7 16083 12 number number NN cord-005453-4057qib7 16083 13 of of IN cord-005453-4057qib7 16083 14 CD34 CD34 NNP cord-005453-4057qib7 16083 15 + + CC cord-005453-4057qib7 16083 16 cells cell NNS cord-005453-4057qib7 16083 17 on on IN cord-005453-4057qib7 16083 18 day day NN cord-005453-4057qib7 16083 19 +4 +4 NN cord-005453-4057qib7 16083 20 was be VBD cord-005453-4057qib7 16083 21 < < XX cord-005453-4057qib7 16083 22 10 10 CD cord-005453-4057qib7 16084 1 /uL /uL : cord-005453-4057qib7 16084 2 for for IN cord-005453-4057qib7 16084 3 2x10 2x10 CD cord-005453-4057qib7 16084 4 6 6 CD cord-005453-4057qib7 16084 5 CD34 CD34 NNP cord-005453-4057qib7 16085 1 + + CC cord-005453-4057qib7 16085 2 /kg /kg NFP cord-005453-4057qib7 16085 3 requested request VBN cord-005453-4057qib7 16085 4 ( ( -LRB- cord-005453-4057qib7 16085 5 or or CC cord-005453-4057qib7 16085 6 < < XX cord-005453-4057qib7 16085 7 20 20 CD cord-005453-4057qib7 16085 8 / / SYM cord-005453-4057qib7 16085 9 uL ul NN cord-005453-4057qib7 16085 10 for for IN cord-005453-4057qib7 16085 11 4x10 4x10 CD cord-005453-4057qib7 16085 12 6 6 CD cord-005453-4057qib7 16085 13 CD34 CD34 NNP cord-005453-4057qib7 16086 1 + + CC cord-005453-4057qib7 16087 1 /kg /kg LS cord-005453-4057qib7 16087 2 ) ) -RRB- cord-005453-4057qib7 16087 3 , , , cord-005453-4057qib7 16087 4 or or CC cord-005453-4057qib7 16087 5 if if IN cord-005453-4057qib7 16087 6 the the DT cord-005453-4057qib7 16087 7 number number NN cord-005453-4057qib7 16087 8 of of IN cord-005453-4057qib7 16087 9 CD34 CD34 NNP cord-005453-4057qib7 16087 10 + + CC cord-005453-4057qib7 16087 11 cells cell NNS cord-005453-4057qib7 16087 12 collected collect VBN cord-005453-4057qib7 16087 13 in in IN cord-005453-4057qib7 16087 14 the the DT cord-005453-4057qib7 16087 15 first first JJ cord-005453-4057qib7 16087 16 apheresis apheresis NN cord-005453-4057qib7 16087 17 was be VBD cord-005453-4057qib7 16087 18 < < XX cord-005453-4057qib7 16087 19 50 50 CD cord-005453-4057qib7 16087 20 % % NN cord-005453-4057qib7 16087 21 of of IN cord-005453-4057qib7 16087 22 CD34 CD34 NNP cord-005453-4057qib7 16088 1 + + CC cord-005453-4057qib7 16088 2 cells cell NNS cord-005453-4057qib7 16088 3 requested request VBD cord-005453-4057qib7 16088 4 . . . cord-005453-4057qib7 16089 1 Between between IN cord-005453-4057qib7 16089 2 January January NNP cord-005453-4057qib7 16089 3 2016 2016 CD cord-005453-4057qib7 16089 4 and and CC cord-005453-4057qib7 16089 5 September September NNP cord-005453-4057qib7 16089 6 2018 2018 CD cord-005453-4057qib7 16089 7 , , , cord-005453-4057qib7 16089 8 37 37 CD cord-005453-4057qib7 16089 9 out out IN cord-005453-4057qib7 16089 10 of of IN cord-005453-4057qib7 16089 11 157pts 157pts CD cord-005453-4057qib7 16089 12 ( ( -LRB- cord-005453-4057qib7 16089 13 23,6 23,6 CD cord-005453-4057qib7 16089 14 % % NN cord-005453-4057qib7 16089 15 ) ) -RRB- cord-005453-4057qib7 16089 16 received receive VBD cord-005453-4057qib7 16089 17 Plerixafor Plerixafor NNP cord-005453-4057qib7 16089 18 for for IN cord-005453-4057qib7 16089 19 mobilization mobilization NN cord-005453-4057qib7 16089 20 . . . cord-005453-4057qib7 16090 1 We -PRON- PRP cord-005453-4057qib7 16090 2 retrospectively retrospectively RB cord-005453-4057qib7 16090 3 studied study VBD cord-005453-4057qib7 16090 4 30 30 CD cord-005453-4057qib7 16090 5 pts pts NN cord-005453-4057qib7 16090 6 who who WP cord-005453-4057qib7 16090 7 mobilized mobilize VBD cord-005453-4057qib7 16090 8 with with IN cord-005453-4057qib7 16090 9 P+G P+G NNP cord-005453-4057qib7 16090 10 - - HYPH cord-005453-4057qib7 16090 11 CSFdue CSFdue NNP cord-005453-4057qib7 16090 12 to to IN cord-005453-4057qib7 16090 13 the the DT cord-005453-4057qib7 16090 14 number number NN cord-005453-4057qib7 16090 15 of of IN cord-005453-4057qib7 16090 16 CD34 CD34 NNP cord-005453-4057qib7 16090 17 + + CC cord-005453-4057qib7 16090 18 cells cell NNS cord-005453-4057qib7 16090 19 on on IN cord-005453-4057qib7 16090 20 day day NN cord-005453-4057qib7 16090 21 +4 +4 NN cord-005453-4057qib7 16090 22 was be VBD cord-005453-4057qib7 16090 23 < < XX cord-005453-4057qib7 16090 24 10 10 CD cord-005453-4057qib7 16091 1 /uL.Results /uL.Results NNP cord-005453-4057qib7 16091 2 : : : cord-005453-4057qib7 16092 1 Twelve twelve CD cord-005453-4057qib7 16092 2 out out IN cord-005453-4057qib7 16092 3 of of IN cord-005453-4057qib7 16092 4 30 30 CD cord-005453-4057qib7 16092 5 pts pt NNS cord-005453-4057qib7 16092 6 were be VBD cord-005453-4057qib7 16092 7 PM PM NNP cord-005453-4057qib7 16092 8 , , , cord-005453-4057qib7 16092 9 7 7 CD cord-005453-4057qib7 16092 10 were be VBD cord-005453-4057qib7 16092 11 females female NNS cord-005453-4057qib7 16092 12 , , , cord-005453-4057qib7 16092 13 median median JJ cord-005453-4057qib7 16092 14 age age NN cord-005453-4057qib7 16093 1 55,5 55,5 CD cord-005453-4057qib7 16093 2 years year NNS cord-005453-4057qib7 16093 3 ( ( -LRB- cord-005453-4057qib7 16093 4 range:32 range:32 NNP cord-005453-4057qib7 16093 5 - - HYPH cord-005453-4057qib7 16093 6 70 70 CD cord-005453-4057qib7 16093 7 ) ) -RRB- cord-005453-4057qib7 16093 8 . . . cord-005453-4057qib7 16094 1 Patients patient NNS cord-005453-4057qib7 16094 2 ' ' POS cord-005453-4057qib7 16094 3 baseline baseline JJ cord-005453-4057qib7 16094 4 diseases disease NNS cord-005453-4057qib7 16094 5 were be VBD cord-005453-4057qib7 16094 6 : : : cord-005453-4057qib7 16094 7 10 10 CD cord-005453-4057qib7 16094 8 non non JJ cord-005453-4057qib7 16094 9 - - JJ cord-005453-4057qib7 16094 10 Hodgkin hodgkin JJ cord-005453-4057qib7 16094 11 lymphoma lymphoma NN cord-005453-4057qib7 16094 12 ( ( -LRB- cord-005453-4057qib7 16094 13 NHL NHL NNP cord-005453-4057qib7 16094 14 ) ) -RRB- cord-005453-4057qib7 16094 15 ( ( -LRB- cord-005453-4057qib7 16094 16 83,3 83,3 CD cord-005453-4057qib7 16094 17 % % NN cord-005453-4057qib7 16094 18 ) ) -RRB- cord-005453-4057qib7 16094 19 , , , cord-005453-4057qib7 16094 20 1 1 CD cord-005453-4057qib7 16094 21 multiple multiple JJ cord-005453-4057qib7 16094 22 myeloma myeloma NN cord-005453-4057qib7 16094 23 ( ( -LRB- cord-005453-4057qib7 16094 24 MM MM NNP cord-005453-4057qib7 16094 25 ) ) -RRB- cord-005453-4057qib7 16094 26 and and CC cord-005453-4057qib7 16094 27 1 1 CD cord-005453-4057qib7 16094 28 Hodgkin Hodgkin NNP cord-005453-4057qib7 16094 29 lymphoma lymphoma NN cord-005453-4057qib7 16094 30 . . . cord-005453-4057qib7 16095 1 Median median JJ cord-005453-4057qib7 16095 2 CD34 CD34 NNP cord-005453-4057qib7 16095 3 + + CC cord-005453-4057qib7 16095 4 cell cell NN cord-005453-4057qib7 16095 5 count count NN cord-005453-4057qib7 16095 6 on on IN cord-005453-4057qib7 16095 7 day day NN cord-005453-4057qib7 16095 8 +4 +4 NN cord-005453-4057qib7 16095 9 was be VBD cord-005453-4057qib7 16095 10 8/ 8/ CD cord-005453-4057qib7 16095 11 uL ul NN cord-005453-4057qib7 16096 1 ( ( -LRB- cord-005453-4057qib7 16096 2 range:6 range:6 NNP cord-005453-4057qib7 16096 3 - - HYPH cord-005453-4057qib7 16096 4 10).There 10).there CD cord-005453-4057qib7 16096 5 was be VBD cord-005453-4057qib7 16096 6 no no DT cord-005453-4057qib7 16096 7 mobilization mobilization NN cord-005453-4057qib7 16096 8 failure failure NN cord-005453-4057qib7 16096 9 . . . cord-005453-4057qib7 16097 1 Eighteen eighteen CD cord-005453-4057qib7 16097 2 out out IN cord-005453-4057qib7 16097 3 of of IN cord-005453-4057qib7 16097 4 30 30 CD cord-005453-4057qib7 16097 5 pts pts NN cord-005453-4057qib7 16097 6 ( ( -LRB- cord-005453-4057qib7 16097 7 60 60 CD cord-005453-4057qib7 16097 8 % % NN cord-005453-4057qib7 16097 9 ) ) -RRB- cord-005453-4057qib7 16097 10 were be VBD cord-005453-4057qib7 16097 11 VPM VPM NNP cord-005453-4057qib7 16097 12 , , , cord-005453-4057qib7 16097 13 9 9 CD cord-005453-4057qib7 16097 14 were be VBD cord-005453-4057qib7 16097 15 females female NNS cord-005453-4057qib7 16097 16 , , , cord-005453-4057qib7 16097 17 median median JJ cord-005453-4057qib7 16097 18 age age NN cord-005453-4057qib7 16097 19 62,5 62,5 CD cord-005453-4057qib7 16097 20 years year NNS cord-005453-4057qib7 16097 21 ( ( -LRB- cord-005453-4057qib7 16097 22 range:34 range:34 NN cord-005453-4057qib7 16097 23 - - HYPH cord-005453-4057qib7 16097 24 69 69 CD cord-005453-4057qib7 16097 25 ) ) -RRB- cord-005453-4057qib7 16097 26 . . . cord-005453-4057qib7 16098 1 Patients patient NNS cord-005453-4057qib7 16098 2 ' ' POS cord-005453-4057qib7 16098 3 baseline baseline JJ cord-005453-4057qib7 16098 4 diseases disease NNS cord-005453-4057qib7 16098 5 were be VBD cord-005453-4057qib7 16098 6 : : : cord-005453-4057qib7 16098 7 10 10 CD cord-005453-4057qib7 16098 8 NHL NHL NNP cord-005453-4057qib7 16098 9 ( ( -LRB- cord-005453-4057qib7 16098 10 55,5 55,5 CD cord-005453-4057qib7 16098 11 % % NN cord-005453-4057qib7 16098 12 ) ) -RRB- cord-005453-4057qib7 16098 13 , , , cord-005453-4057qib7 16098 14 7 7 CD cord-005453-4057qib7 16098 15 MM mm NN cord-005453-4057qib7 16098 16 and and CC cord-005453-4057qib7 16098 17 1 1 CD cord-005453-4057qib7 16098 18 solid solid JJ cord-005453-4057qib7 16098 19 tumor tumor NN cord-005453-4057qib7 16098 20 . . . cord-005453-4057qib7 16099 1 Median median JJ cord-005453-4057qib7 16099 2 CD34 CD34 NNP cord-005453-4057qib7 16099 3 + + CC cord-005453-4057qib7 16099 4 cell cell NN cord-005453-4057qib7 16099 5 count count NN cord-005453-4057qib7 16099 6 on on IN cord-005453-4057qib7 16099 7 day+4 day+4 NNP cord-005453-4057qib7 16099 8 was be VBD cord-005453-4057qib7 16099 9 2,5/ 2,5/ CD cord-005453-4057qib7 16100 1 uL uL NNP cord-005453-4057qib7 16101 1 ( ( -LRB- cord-005453-4057qib7 16101 2 range:2 range:2 NNP cord-005453-4057qib7 16101 3 - - HYPH cord-005453-4057qib7 16101 4 5 5 CD cord-005453-4057qib7 16101 5 ) ) -RRB- cord-005453-4057qib7 16101 6 . . . cord-005453-4057qib7 16102 1 Two two CD cord-005453-4057qib7 16102 2 out out IN cord-005453-4057qib7 16102 3 of of IN cord-005453-4057qib7 16102 4 18 18 CD cord-005453-4057qib7 16102 5 pts pt NNS cord-005453-4057qib7 16102 6 ( ( -LRB- cord-005453-4057qib7 16102 7 16,6 16,6 CD cord-005453-4057qib7 16102 8 % % NN cord-005453-4057qib7 16102 9 ) ) -RRB- cord-005453-4057qib7 16102 10 were be VBD cord-005453-4057qib7 16102 11 considered consider VBN cord-005453-4057qib7 16102 12 mobilization mobilization NN cord-005453-4057qib7 16102 13 failure failure NN cord-005453-4057qib7 16102 14 , , , cord-005453-4057qib7 16102 15 in in IN cord-005453-4057qib7 16102 16 2 2 CD cord-005453-4057qib7 16102 17 of of IN cord-005453-4057qib7 16102 18 them -PRON- PRP cord-005453-4057qib7 16102 19 did do VBD cord-005453-4057qib7 16102 20 not not RB cord-005453-4057qib7 16102 21 realized realize VBN cord-005453-4057qib7 16102 22 apheresis apheresis NN cord-005453-4057qib7 16102 23 due due IN cord-005453-4057qib7 16102 24 to to IN cord-005453-4057qib7 16102 25 CD34 CD34 NNP cord-005453-4057qib7 16102 26 + + CC cord-005453-4057qib7 16103 1 cell cell NN cord-005453-4057qib7 16103 2 count count NN cord-005453-4057qib7 16103 3 on on IN cord-005453-4057qib7 16103 4 day day NN cord-005453-4057qib7 16103 5 +5 +5 NFP cord-005453-4057qib7 16103 6 was be VBD cord-005453-4057qib7 16103 7 2/ 2/ CD cord-005453-4057qib7 16104 1 uL. ul. LS cord-005453-4057qib7 16104 2 No no DT cord-005453-4057qib7 16104 3 difference difference NN cord-005453-4057qib7 16104 4 was be VBD cord-005453-4057qib7 16104 5 seen see VBN cord-005453-4057qib7 16104 6 between between IN cord-005453-4057qib7 16104 7 both both DT cord-005453-4057qib7 16104 8 groups group NNS cord-005453-4057qib7 16104 9 regarding regard VBG cord-005453-4057qib7 16104 10 gender gender NN cord-005453-4057qib7 16104 11 , , , cord-005453-4057qib7 16104 12 age age NN cord-005453-4057qib7 16104 13 , , , cord-005453-4057qib7 16104 14 patients patient NNS cord-005453-4057qib7 16104 15 baseline baseline JJ cord-005453-4057qib7 16104 16 disease disease NN cord-005453-4057qib7 16104 17 or or CC cord-005453-4057qib7 16104 18 median median JJ cord-005453-4057qib7 16104 19 CD34 CD34 NNP cord-005453-4057qib7 16104 20 + + CC cord-005453-4057qib7 16104 21 cells cell NNS cord-005453-4057qib7 16104 22 count count VBP cord-005453-4057qib7 16104 23 on on IN cord-005453-4057qib7 16104 24 day day NN cord-005453-4057qib7 16104 25 +4.VPM +4.VPM . cord-005453-4057qib7 16104 26 needed need VBN cord-005453-4057qib7 16104 27 more more JJR cord-005453-4057qib7 16104 28 apheresis apheresis NN cord-005453-4057qib7 16104 29 sessions session NNS cord-005453-4057qib7 16104 30 , , , cord-005453-4057qib7 16104 31 5/16 5/16 CD cord-005453-4057qib7 16104 32 pts pts NN cord-005453-4057qib7 16104 33 required require VBN cord-005453-4057qib7 16104 34 2 2 CD cord-005453-4057qib7 16104 35 sessions session NNS cord-005453-4057qib7 16104 36 against against IN cord-005453-4057qib7 16104 37 1/12 1/12 CD cord-005453-4057qib7 16104 38 pts pt NNS cord-005453-4057qib7 16104 39 in in IN cord-005453-4057qib7 16104 40 PM pm NN cord-005453-4057qib7 16104 41 ( ( -LRB- cord-005453-4057qib7 16104 42 p p NN cord-005453-4057qib7 16104 43 = = SYM cord-005453-4057qib7 16104 44 not not RB cord-005453-4057qib7 16104 45 significant significant JJ cord-005453-4057qib7 16104 46 ( ( -LRB- cord-005453-4057qib7 16104 47 ns ns IN cord-005453-4057qib7 16104 48 ) ) -RRB- cord-005453-4057qib7 16104 49 . . . cord-005453-4057qib7 16105 1 We -PRON- PRP cord-005453-4057qib7 16105 2 obtained obtain VBD cord-005453-4057qib7 16105 3 enough enough JJ cord-005453-4057qib7 16105 4 cells cell NNS cord-005453-4057qib7 16105 5 to to TO cord-005453-4057qib7 16105 6 carry carry VB cord-005453-4057qib7 16105 7 ASCT ASCT NNP cord-005453-4057qib7 16105 8 in in IN cord-005453-4057qib7 16105 9 90 90 CD cord-005453-4057qib7 16105 10 % % NN cord-005453-4057qib7 16105 11 pts pt NNS cord-005453-4057qib7 16105 12 , , , cord-005453-4057qib7 16105 13 although although IN cord-005453-4057qib7 16105 14 mean mean JJ cord-005453-4057qib7 16105 15 number number NN cord-005453-4057qib7 16105 16 of of IN cord-005453-4057qib7 16105 17 CD34 CD34 NNP cord-005453-4057qib7 16105 18 + + CC cord-005453-4057qib7 16105 19 cells cell NNS cord-005453-4057qib7 16105 20 obtained obtain VBN cord-005453-4057qib7 16105 21 in in IN cord-005453-4057qib7 16105 22 VPM VPM NNP cord-005453-4057qib7 16105 23 was be VBD cord-005453-4057qib7 16105 24 lower low JJR cord-005453-4057qib7 16105 25 than than IN cord-005453-4057qib7 16105 26 in in IN cord-005453-4057qib7 16105 27 PM PM NNP cord-005453-4057qib7 16105 28 ( ( -LRB- cord-005453-4057qib7 16105 29 4,89x10 4,89x10 CD cord-005453-4057qib7 16105 30 6 6 CD cord-005453-4057qib7 16105 31 /kg /kg . cord-005453-4057qib7 16105 32 vs vs IN cord-005453-4057qib7 16105 33 6,38x10 6,38x10 CD cord-005453-4057qib7 16105 34 6 6 CD cord-005453-4057qib7 16105 35 /kg /kg NN cord-005453-4057qib7 16105 36 , , , cord-005453-4057qib7 16105 37 respectively respectively RB cord-005453-4057qib7 16105 38 ) ) -RRB- cord-005453-4057qib7 16106 1 ( ( -LRB- cord-005453-4057qib7 16106 2 p p NN cord-005453-4057qib7 16106 3 = = SYM cord-005453-4057qib7 16106 4 ns).Twenty ns).Twenty NNP cord-005453-4057qib7 16106 5 - - HYPH cord-005453-4057qib7 16106 6 six six CD cord-005453-4057qib7 16106 7 pts pt NNS cord-005453-4057qib7 16106 8 underwent undergo VBD cord-005453-4057qib7 16106 9 ASCT ASCT NNP cord-005453-4057qib7 16106 10 and and CC cord-005453-4057qib7 16106 11 mean mean JJ cord-005453-4057qib7 16106 12 number number NN cord-005453-4057qib7 16106 13 of of IN cord-005453-4057qib7 16106 14 CD34 CD34 NNP cord-005453-4057qib7 16107 1 + + CC cord-005453-4057qib7 16107 2 cells cell NNS cord-005453-4057qib7 16107 3 infused infuse VBN cord-005453-4057qib7 16107 4 were be VBD cord-005453-4057qib7 16107 5 4,27x10 4,27x10 CD cord-005453-4057qib7 16107 6 6 6 CD cord-005453-4057qib7 16108 1 /kg /kg NFP cord-005453-4057qib7 16108 2 in in IN cord-005453-4057qib7 16108 3 VPM VPM NNP cord-005453-4057qib7 16109 1 vs vs IN cord-005453-4057qib7 16109 2 have have VBP cord-005453-4057qib7 16109 3 been be VBN cord-005453-4057qib7 16109 4 the the DT cord-005453-4057qib7 16109 5 only only JJ cord-005453-4057qib7 16109 6 route route NN cord-005453-4057qib7 16109 7 used use VBN cord-005453-4057qib7 16109 8 for for IN cord-005453-4057qib7 16109 9 cHPC cHPC NNP cord-005453-4057qib7 16109 10 administration administration NN cord-005453-4057qib7 16109 11 . . . cord-005453-4057qib7 16110 1 The the DT cord-005453-4057qib7 16110 2 appearance appearance NN cord-005453-4057qib7 16110 3 of of IN cord-005453-4057qib7 16110 4 other other JJ cord-005453-4057qib7 16110 5 catheters catheter NNS cord-005453-4057qib7 16110 6 types type NNS cord-005453-4057qib7 16110 7 made make VBD cord-005453-4057qib7 16110 8 us -PRON- PRP cord-005453-4057qib7 16110 9 to to TO cord-005453-4057qib7 16110 10 reconsider reconsider VB cord-005453-4057qib7 16110 11 the the DT cord-005453-4057qib7 16110 12 exclusive exclusive JJ cord-005453-4057qib7 16110 13 use use NN cord-005453-4057qib7 16110 14 of of IN cord-005453-4057qib7 16110 15 the the DT cord-005453-4057qib7 16110 16 CVC CVC NNP cord-005453-4057qib7 16110 17 for for IN cord-005453-4057qib7 16110 18 the the DT cord-005453-4057qib7 16110 19 infusion infusion NN cord-005453-4057qib7 16110 20 of of IN cord-005453-4057qib7 16110 21 cHPC cHPC NNP cord-005453-4057qib7 16110 22 . . . cord-005453-4057qib7 16111 1 We -PRON- PRP cord-005453-4057qib7 16111 2 analyzed analyze VBD cord-005453-4057qib7 16111 3 the the DT cord-005453-4057qib7 16111 4 use use NN cord-005453-4057qib7 16111 5 of of IN cord-005453-4057qib7 16111 6 a a DT cord-005453-4057qib7 16111 7 peripheral peripheral JJ cord-005453-4057qib7 16111 8 IV IV NNP cord-005453-4057qib7 16111 9 cannula cannula NN cord-005453-4057qib7 16111 10 ( ( -LRB- cord-005453-4057qib7 16111 11 PIVC PIVC NNP cord-005453-4057qib7 16111 12 ) ) -RRB- cord-005453-4057qib7 16111 13 as as IN cord-005453-4057qib7 16111 14 an an DT cord-005453-4057qib7 16111 15 alternative alternative NN cord-005453-4057qib7 16111 16 to to IN cord-005453-4057qib7 16111 17 CVC CVC NNP cord-005453-4057qib7 16111 18 for for IN cord-005453-4057qib7 16111 19 the the DT cord-005453-4057qib7 16111 20 infusion infusion NN cord-005453-4057qib7 16111 21 of of IN cord-005453-4057qib7 16111 22 cHPC chpc NN cord-005453-4057qib7 16111 23 in in IN cord-005453-4057qib7 16111 24 patients patient NNS cord-005453-4057qib7 16111 25 with with IN cord-005453-4057qib7 16111 26 cardiovascular cardiovascular JJ cord-005453-4057qib7 16111 27 diseases disease NNS cord-005453-4057qib7 16111 28 . . . cord-005453-4057qib7 16112 1 Methods method NNS cord-005453-4057qib7 16112 2 : : : cord-005453-4057qib7 16112 3 Medical medical JJ cord-005453-4057qib7 16112 4 records record NNS cord-005453-4057qib7 16112 5 of of IN cord-005453-4057qib7 16112 6 65 65 CD cord-005453-4057qib7 16112 7 patients patient NNS cord-005453-4057qib7 16112 8 who who WP cord-005453-4057qib7 16112 9 received receive VBD cord-005453-4057qib7 16112 10 an an DT cord-005453-4057qib7 16112 11 ASCT asct NN cord-005453-4057qib7 16112 12 for for IN cord-005453-4057qib7 16112 13 hematological hematological JJ cord-005453-4057qib7 16112 14 malignant malignant JJ cord-005453-4057qib7 16112 15 diseases disease NNS cord-005453-4057qib7 16112 16 at at IN cord-005453-4057qib7 16112 17 the the DT cord-005453-4057qib7 16112 18 Hospital Hospital NNP cord-005453-4057qib7 16112 19 Clínic Clínic NNP cord-005453-4057qib7 16112 20 of of IN cord-005453-4057qib7 16112 21 Barcelona Barcelona NNP cord-005453-4057qib7 16112 22 from from IN cord-005453-4057qib7 16112 23 January January NNP cord-005453-4057qib7 16112 24 2017 2017 CD cord-005453-4057qib7 16112 25 to to IN cord-005453-4057qib7 16112 26 February February NNP cord-005453-4057qib7 16112 27 2018 2018 CD cord-005453-4057qib7 16112 28 were be VBD cord-005453-4057qib7 16112 29 reviewed review VBN cord-005453-4057qib7 16112 30 . . . cord-005453-4057qib7 16113 1 Of of IN cord-005453-4057qib7 16113 2 those those DT cord-005453-4057qib7 16113 3 , , , cord-005453-4057qib7 16113 4 eight eight CD cord-005453-4057qib7 16113 5 were be VBD cord-005453-4057qib7 16113 6 infused infuse VBN cord-005453-4057qib7 16113 7 through through IN cord-005453-4057qib7 16113 8 a a DT cord-005453-4057qib7 16113 9 PIVC PIVC NNP cord-005453-4057qib7 16113 10 due due JJ cord-005453-4057qib7 16113 11 to to IN cord-005453-4057qib7 16113 12 cardiac cardiac JJ cord-005453-4057qib7 16113 13 impairment impairment NN cord-005453-4057qib7 16113 14 related relate VBN cord-005453-4057qib7 16113 15 to to IN cord-005453-4057qib7 16113 16 previous previous JJ cord-005453-4057qib7 16113 17 treatments treatment NNS cord-005453-4057qib7 16113 18 , , , cord-005453-4057qib7 16113 19 ischemic ischemic JJ cord-005453-4057qib7 16113 20 cardiomyopathy cardiomyopathy NN cord-005453-4057qib7 16113 21 or or CC cord-005453-4057qib7 16113 22 amyloid amyloid NN cord-005453-4057qib7 16113 23 deposition deposition NN cord-005453-4057qib7 16113 24 . . . cord-005453-4057qib7 16114 1 HPC HPC NNP cord-005453-4057qib7 16114 2 were be VBD cord-005453-4057qib7 16114 3 obtained obtain VBN cord-005453-4057qib7 16114 4 from from IN cord-005453-4057qib7 16114 5 peripheral peripheral JJ cord-005453-4057qib7 16114 6 blood blood NN cord-005453-4057qib7 16114 7 by by IN cord-005453-4057qib7 16114 8 apheresis apheresis NN cord-005453-4057qib7 16114 9 after after IN cord-005453-4057qib7 16114 10 mobilization mobilization NN cord-005453-4057qib7 16114 11 with with IN cord-005453-4057qib7 16114 12 G G NNP cord-005453-4057qib7 16114 13 - - HYPH cord-005453-4057qib7 16114 14 CSF CSF NNP cord-005453-4057qib7 16114 15 using use VBG cord-005453-4057qib7 16114 16 ACD ACD NNP cord-005453-4057qib7 16114 17 - - HYPH cord-005453-4057qib7 16114 18 A A NNP cord-005453-4057qib7 16114 19 as as IN cord-005453-4057qib7 16114 20 an an DT cord-005453-4057qib7 16114 21 anticoagulant anticoagulant NN cord-005453-4057qib7 16114 22 . . . cord-005453-4057qib7 16115 1 Cryopreservation Cryopreservation NNP cord-005453-4057qib7 16115 2 was be VBD cord-005453-4057qib7 16115 3 performed perform VBN cord-005453-4057qib7 16115 4 with with IN cord-005453-4057qib7 16115 5 autologous autologous JJ cord-005453-4057qib7 16115 6 plasma plasma NN cord-005453-4057qib7 16115 7 and and CC cord-005453-4057qib7 16115 8 DMSO DMSO NNP cord-005453-4057qib7 16115 9 10 10 CD cord-005453-4057qib7 16115 10 % % NN cord-005453-4057qib7 16115 11 by by IN cord-005453-4057qib7 16115 12 mechanical mechanical JJ cord-005453-4057qib7 16115 13 means mean NNS cord-005453-4057qib7 16115 14 and and CC cord-005453-4057qib7 16115 15 stored store VBN cord-005453-4057qib7 16115 16 in in IN cord-005453-4057qib7 16115 17 liquid liquid JJ cord-005453-4057qib7 16115 18 nitrogen nitrogen NN cord-005453-4057qib7 16115 19 . . . cord-005453-4057qib7 16116 1 Analytical analytical JJ cord-005453-4057qib7 16116 2 controls control NNS cord-005453-4057qib7 16116 3 were be VBD cord-005453-4057qib7 16116 4 performed perform VBN cord-005453-4057qib7 16116 5 including include VBG cord-005453-4057qib7 16116 6 hematocrit hematocrit NN cord-005453-4057qib7 16116 7 , , , cord-005453-4057qib7 16116 8 total total JJ cord-005453-4057qib7 16116 9 nucleated nucleated JJ cord-005453-4057qib7 16116 10 cells cell NNS cord-005453-4057qib7 16116 11 , , , cord-005453-4057qib7 16116 12 total total JJ cord-005453-4057qib7 16116 13 polymorphonuclear polymorphonuclear JJ cord-005453-4057qib7 16116 14 neutrophils neutrophil NNS cord-005453-4057qib7 16116 15 and and CC cord-005453-4057qib7 16116 16 platelets platelet NNS cord-005453-4057qib7 16116 17 using use VBG cord-005453-4057qib7 16116 18 the the DT cord-005453-4057qib7 16116 19 ADVIA ADVIA NNP cord-005453-4057qib7 16116 20 120 120 CD cord-005453-4057qib7 16116 21 analyzer analyzer NN cord-005453-4057qib7 16116 22 . . . cord-005453-4057qib7 16117 1 The the DT cord-005453-4057qib7 16117 2 CD34 CD34 NNP cord-005453-4057qib7 16118 1 + + CC cord-005453-4057qib7 16119 1 / / NFP cord-005453-4057qib7 16120 1 CD45 CD45 NNP cord-005453-4057qib7 16120 2 + + CC cord-005453-4057qib7 16120 3 population population NN cord-005453-4057qib7 16120 4 was be VBD cord-005453-4057qib7 16120 5 analyzed analyze VBN cord-005453-4057qib7 16120 6 by by IN cord-005453-4057qib7 16120 7 flow flow NN cord-005453-4057qib7 16120 8 cytometry cytometry NN cord-005453-4057qib7 16120 9 following follow VBG cord-005453-4057qib7 16120 10 the the DT cord-005453-4057qib7 16120 11 ISHAGE ISHAGE NNP cord-005453-4057qib7 16120 12 single single JJ cord-005453-4057qib7 16120 13 - - HYPH cord-005453-4057qib7 16120 14 platform platform NN cord-005453-4057qib7 16120 15 protocol protocol NN cord-005453-4057qib7 16120 16 . . . cord-005453-4057qib7 16121 1 Viability viability NN cord-005453-4057qib7 16121 2 of of IN cord-005453-4057qib7 16121 3 total total JJ cord-005453-4057qib7 16121 4 nucleated nucleated JJ cord-005453-4057qib7 16121 5 cellularity cellularity NN cord-005453-4057qib7 16121 6 was be VBD cord-005453-4057qib7 16121 7 carried carry VBN cord-005453-4057qib7 16121 8 out out RP cord-005453-4057qib7 16121 9 by by IN cord-005453-4057qib7 16121 10 vital vital JJ cord-005453-4057qib7 16121 11 staining staining NN cord-005453-4057qib7 16121 12 with with IN cord-005453-4057qib7 16121 13 Acridine Acridine NNP cord-005453-4057qib7 16121 14 Orange Orange NNP cord-005453-4057qib7 16121 15 and and CC cord-005453-4057qib7 16121 16 the the DT cord-005453-4057qib7 16121 17 specific specific JJ cord-005453-4057qib7 16121 18 viability viability NN cord-005453-4057qib7 16121 19 of of IN cord-005453-4057qib7 16121 20 the the DT cord-005453-4057qib7 16121 21 CD34 CD34 NNP cord-005453-4057qib7 16121 22 + + CC cord-005453-4057qib7 16121 23 population population NN cord-005453-4057qib7 16121 24 through through IN cord-005453-4057qib7 16121 25 the the DT cord-005453-4057qib7 16121 26 technique technique NN cord-005453-4057qib7 16121 27 of of IN cord-005453-4057qib7 16121 28 7-Aminoactinomycin 7-Aminoactinomycin NNP cord-005453-4057qib7 16121 29 D. D. NNP cord-005453-4057qib7 16121 30 Thawing Thawing NNP cord-005453-4057qib7 16121 31 was be VBD cord-005453-4057qib7 16121 32 performed perform VBN cord-005453-4057qib7 16121 33 bag bag NN cord-005453-4057qib7 16121 34 to to TO cord-005453-4057qib7 16121 35 bag bag NN cord-005453-4057qib7 16121 36 by by IN cord-005453-4057qib7 16121 37 immersion immersion NN cord-005453-4057qib7 16121 38 in in IN cord-005453-4057qib7 16121 39 a a DT cord-005453-4057qib7 16121 40 water water NN cord-005453-4057qib7 16121 41 bath bath NN cord-005453-4057qib7 16121 42 at at IN cord-005453-4057qib7 16121 43 37ºC 37ºc CD cord-005453-4057qib7 16121 44 and and CC cord-005453-4057qib7 16121 45 transferred transfer VBN cord-005453-4057qib7 16121 46 to to IN cord-005453-4057qib7 16121 47 the the DT cord-005453-4057qib7 16121 48 bedside bedside NN cord-005453-4057qib7 16121 49 of of IN cord-005453-4057qib7 16121 50 the the DT cord-005453-4057qib7 16121 51 patient patient NN cord-005453-4057qib7 16121 52 for for IN cord-005453-4057qib7 16121 53 gravity gravity NN cord-005453-4057qib7 16121 54 infusion infusion NN cord-005453-4057qib7 16121 55 using use VBG cord-005453-4057qib7 16121 56 an an DT cord-005453-4057qib7 16121 57 infusion infusion NN cord-005453-4057qib7 16121 58 set set VBN cord-005453-4057qib7 16121 59 without without IN cord-005453-4057qib7 16121 60 filter filter NN cord-005453-4057qib7 16121 61 through through IN cord-005453-4057qib7 16121 62 PIVC PIVC NNP cord-005453-4057qib7 16121 63 of of IN cord-005453-4057qib7 16121 64 22 22 CD cord-005453-4057qib7 16121 65 Gauche gauche JJ cord-005453-4057qib7 16121 66 . . . cord-005453-4057qib7 16122 1 Vital vital JJ cord-005453-4057qib7 16122 2 sings sing VBZ cord-005453-4057qib7 16122 3 monitoring monitor VBG cord-005453-4057qib7 16122 4 performed perform VBN cord-005453-4057qib7 16122 5 before before RB cord-005453-4057qib7 16122 6 , , , cord-005453-4057qib7 16122 7 during during IN cord-005453-4057qib7 16122 8 and and CC cord-005453-4057qib7 16122 9 the the DT cord-005453-4057qib7 16122 10 end end NN cord-005453-4057qib7 16122 11 of of IN cord-005453-4057qib7 16122 12 the the DT cord-005453-4057qib7 16122 13 every every DT cord-005453-4057qib7 16122 14 infusion infusion NN cord-005453-4057qib7 16122 15 bag bag NN cord-005453-4057qib7 16122 16 including include VBG cord-005453-4057qib7 16122 17 : : : cord-005453-4057qib7 16122 18 blood blood NN cord-005453-4057qib7 16122 19 pressure pressure NN cord-005453-4057qib7 16122 20 , , , cord-005453-4057qib7 16122 21 heart heart NN cord-005453-4057qib7 16122 22 rate rate NN cord-005453-4057qib7 16122 23 , , , cord-005453-4057qib7 16122 24 oxygen oxygen NN cord-005453-4057qib7 16122 25 saturation saturation NN cord-005453-4057qib7 16122 26 , , , cord-005453-4057qib7 16122 27 body body NN cord-005453-4057qib7 16122 28 temperature temperature NN cord-005453-4057qib7 16122 29 and and CC cord-005453-4057qib7 16122 30 central central JJ cord-005453-4057qib7 16122 31 venous venous JJ cord-005453-4057qib7 16122 32 pressure pressure NN cord-005453-4057qib7 16122 33 . . . cord-005453-4057qib7 16123 1 Other other JJ cord-005453-4057qib7 16123 2 aspects aspect NNS cord-005453-4057qib7 16123 3 assessed assess VBN cord-005453-4057qib7 16123 4 during during IN cord-005453-4057qib7 16123 5 the the DT cord-005453-4057qib7 16123 6 infusion infusion NN cord-005453-4057qib7 16123 7 were be VBD cord-005453-4057qib7 16123 8 pain pain NN cord-005453-4057qib7 16123 9 , , , cord-005453-4057qib7 16123 10 cold cold JJ cord-005453-4057qib7 16123 11 sensation sensation NN cord-005453-4057qib7 16123 12 and and CC cord-005453-4057qib7 16123 13 signs sign NNS cord-005453-4057qib7 16123 14 of of IN cord-005453-4057qib7 16123 15 extravasation extravasation NN cord-005453-4057qib7 16123 16 in in IN cord-005453-4057qib7 16123 17 the the DT cord-005453-4057qib7 16123 18 area area NN cord-005453-4057qib7 16123 19 of of IN cord-005453-4057qib7 16123 20 PIVC PIVC NNP cord-005453-4057qib7 16123 21 insertion insertion NN cord-005453-4057qib7 16123 22 . . . cord-005453-4057qib7 16124 1 After after IN cord-005453-4057qib7 16124 2 the the DT cord-005453-4057qib7 16124 3 infusion infusion NN cord-005453-4057qib7 16124 4 , , , cord-005453-4057qib7 16124 5 the the DT cord-005453-4057qib7 16124 6 recovery recovery NN cord-005453-4057qib7 16124 7 time time NN cord-005453-4057qib7 16124 8 of of IN cord-005453-4057qib7 16124 9 the the DT cord-005453-4057qib7 16124 10 granulocyte granulocyte NNP cord-005453-4057qib7 16124 11 series series NN cord-005453-4057qib7 16124 12 and and CC cord-005453-4057qib7 16124 13 platelet platelet NN cord-005453-4057qib7 16124 14 were be VBD cord-005453-4057qib7 16124 15 evaluated evaluate VBN cord-005453-4057qib7 16124 16 . . . cord-005453-4057qib7 16125 1 Results result NNS cord-005453-4057qib7 16125 2 : : : cord-005453-4057qib7 16126 1 Median median JJ cord-005453-4057qib7 16126 2 volume volume NN cord-005453-4057qib7 16126 3 and and CC cord-005453-4057qib7 16126 4 bags bag NNS cord-005453-4057qib7 16126 5 administered administer VBN cord-005453-4057qib7 16126 6 was be VBD cord-005453-4057qib7 16126 7 480 480 CD cord-005453-4057qib7 16126 8 ( ( -LRB- cord-005453-4057qib7 16126 9 360 360 CD cord-005453-4057qib7 16126 10 - - HYPH cord-005453-4057qib7 16126 11 600 600 CD cord-005453-4057qib7 16126 12 ) ) -RRB- cord-005453-4057qib7 16126 13 mL ml NN cord-005453-4057qib7 16126 14 and and CC cord-005453-4057qib7 16126 15 4 4 CD cord-005453-4057qib7 16126 16 ( ( -LRB- cord-005453-4057qib7 16126 17 3 3 CD cord-005453-4057qib7 16126 18 ) ) -RRB- cord-005453-4057qib7 16127 1 ( ( -LRB- cord-005453-4057qib7 16127 2 4 4 LS cord-005453-4057qib7 16127 3 ) ) -RRB- cord-005453-4057qib7 16127 4 ( ( -LRB- cord-005453-4057qib7 16127 5 5 5 CD cord-005453-4057qib7 16127 6 ) ) -RRB- cord-005453-4057qib7 16127 7 . . . cord-005453-4057qib7 16128 1 The the DT cord-005453-4057qib7 16128 2 median median NN cord-005453-4057qib7 16128 3 of of IN cord-005453-4057qib7 16128 4 total total JJ cord-005453-4057qib7 16128 5 nucleated nucleated JJ cord-005453-4057qib7 16128 6 cells cell NNS cord-005453-4057qib7 16128 7 , , , cord-005453-4057qib7 16128 8 total total JJ cord-005453-4057qib7 16128 9 nucleated nucleated JJ cord-005453-4057qib7 16128 10 cells cell NNS cord-005453-4057qib7 16128 11 / / SYM cord-005453-4057qib7 16128 12 mL ml NN cord-005453-4057qib7 16128 13 and and CC cord-005453-4057qib7 16129 1 total total JJ cord-005453-4057qib7 16129 2 CD34 CD34 NNP cord-005453-4057qib7 16130 1 + + CC cord-005453-4057qib7 16131 1 cells cell NNS cord-005453-4057qib7 16131 2 / / SYM cord-005453-4057qib7 16131 3 Kg Kg NNP cord-005453-4057qib7 16131 4 was be VBD cord-005453-4057qib7 16131 5 462.6 462.6 CD cord-005453-4057qib7 16131 6 x x SYM cord-005453-4057qib7 16131 7 10 10 CD cord-005453-4057qib7 16131 8 8 8 CD cord-005453-4057qib7 16131 9 ( ( -LRB- cord-005453-4057qib7 16131 10 329.5 329.5 CD cord-005453-4057qib7 16131 11 - - HYPH cord-005453-4057qib7 16131 12 657.8 657.8 CD cord-005453-4057qib7 16131 13 ) ) -RRB- cord-005453-4057qib7 16131 14 , , . cord-005453-4057qib7 16132 1 107.3 107.3 CD cord-005453-4057qib7 16132 2 x x SYM cord-005453-4057qib7 16132 3 10 10 CD cord-005453-4057qib7 16132 4 8 8 CD cord-005453-4057qib7 16132 5 ( ( -LRB- cord-005453-4057qib7 16132 6 64.66 64.66 CD cord-005453-4057qib7 16132 7 - - SYM cord-005453-4057qib7 16132 8 156.7 156.7 CD cord-005453-4057qib7 16132 9 ) ) -RRB- cord-005453-4057qib7 16132 10 and and CC cord-005453-4057qib7 16132 11 3.24 3.24 CD cord-005453-4057qib7 16132 12 ( ( -LRB- cord-005453-4057qib7 16132 13 2.46 2.46 CD cord-005453-4057qib7 16132 14 - - SYM cord-005453-4057qib7 16132 15 4.6 4.6 CD cord-005453-4057qib7 16132 16 ) ) -RRB- cord-005453-4057qib7 16132 17 respectively respectively RB cord-005453-4057qib7 16132 18 . . . cord-005453-4057qib7 16133 1 Vital vital JJ cord-005453-4057qib7 16133 2 signs sign NNS cord-005453-4057qib7 16133 3 were be VBD cord-005453-4057qib7 16133 4 within within IN cord-005453-4057qib7 16133 5 the the DT cord-005453-4057qib7 16133 6 normal normal JJ cord-005453-4057qib7 16133 7 range range NN cord-005453-4057qib7 16133 8 and and CC cord-005453-4057qib7 16133 9 allowed allow VBD cord-005453-4057qib7 16133 10 to to TO cord-005453-4057qib7 16133 11 perform perform VB cord-005453-4057qib7 16133 12 the the DT cord-005453-4057qib7 16133 13 infusion infusion NN cord-005453-4057qib7 16133 14 in in IN cord-005453-4057qib7 16133 15 an an DT cord-005453-4057qib7 16133 16 average average NN cord-005453-4057qib7 16133 17 of of IN cord-005453-4057qib7 16133 18 20 20 CD cord-005453-4057qib7 16133 19 - - SYM cord-005453-4057qib7 16133 20 30 30 CD cord-005453-4057qib7 16133 21 minutes minute NNS cord-005453-4057qib7 16133 22 / / SYM cord-005453-4057qib7 16133 23 bag bag NN cord-005453-4057qib7 16133 24 . . . cord-005453-4057qib7 16134 1 No no DT cord-005453-4057qib7 16134 2 patient patient NN cord-005453-4057qib7 16134 3 required require VBD cord-005453-4057qib7 16134 4 stopping stop VBG cord-005453-4057qib7 16134 5 the the DT cord-005453-4057qib7 16134 6 infusion infusion NN cord-005453-4057qib7 16134 7 due due IN cord-005453-4057qib7 16134 8 to to IN cord-005453-4057qib7 16134 9 pain pain NN cord-005453-4057qib7 16134 10 in in IN cord-005453-4057qib7 16134 11 the the DT cord-005453-4057qib7 16134 12 area area NN cord-005453-4057qib7 16134 13 of of IN cord-005453-4057qib7 16134 14 peripheral peripheral JJ cord-005453-4057qib7 16134 15 catheter catheter NN cord-005453-4057qib7 16134 16 insertion insertion NN cord-005453-4057qib7 16134 17 and and CC cord-005453-4057qib7 16134 18 no no DT cord-005453-4057qib7 16134 19 extravasations extravasation NNS cord-005453-4057qib7 16134 20 were be VBD cord-005453-4057qib7 16134 21 detected detect VBN cord-005453-4057qib7 16134 22 . . . cord-005453-4057qib7 16135 1 All all DT cord-005453-4057qib7 16135 2 patients patient NNS cord-005453-4057qib7 16135 3 referred refer VBD cord-005453-4057qib7 16135 4 some some DT cord-005453-4057qib7 16135 5 cold cold JJ cord-005453-4057qib7 16135 6 sensation sensation NN cord-005453-4057qib7 16135 7 in in IN cord-005453-4057qib7 16135 8 the the DT cord-005453-4057qib7 16135 9 insertion insertion NN cord-005453-4057qib7 16135 10 vein vein NN cord-005453-4057qib7 16135 11 and and CC cord-005453-4057qib7 16135 12 its -PRON- PRP$ cord-005453-4057qib7 16135 13 path path NN cord-005453-4057qib7 16135 14 . . . cord-005453-4057qib7 16136 1 Median median JJ cord-005453-4057qib7 16136 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 16136 3 recovery recovery NN cord-005453-4057qib7 16136 4 was be VBD cord-005453-4057qib7 16136 5 14 14 CD cord-005453-4057qib7 16136 6 ( ( -LRB- cord-005453-4057qib7 16136 7 11 11 CD cord-005453-4057qib7 16136 8 - - SYM cord-005453-4057qib7 16136 9 19 19 CD cord-005453-4057qib7 16136 10 ) ) -RRB- cord-005453-4057qib7 16136 11 days day NNS cord-005453-4057qib7 16136 12 for for IN cord-005453-4057qib7 16136 13 neutrophils neutrophil NNS cord-005453-4057qib7 16136 14 and and CC cord-005453-4057qib7 16136 15 11 11 CD cord-005453-4057qib7 16136 16 ( ( -LRB- cord-005453-4057qib7 16136 17 0 0 CD cord-005453-4057qib7 16136 18 - - SYM cord-005453-4057qib7 16136 19 19 19 CD cord-005453-4057qib7 16136 20 ) ) -RRB- cord-005453-4057qib7 16136 21 days day NNS cord-005453-4057qib7 16136 22 for for IN cord-005453-4057qib7 16136 23 platelets platelet NNS cord-005453-4057qib7 16136 24 , , , cord-005453-4057qib7 16136 25 similar similar JJ cord-005453-4057qib7 16136 26 to to IN cord-005453-4057qib7 16136 27 the the DT cord-005453-4057qib7 16136 28 recovery recovery NN cord-005453-4057qib7 16136 29 experienced experience VBN cord-005453-4057qib7 16136 30 from from IN cord-005453-4057qib7 16136 31 patients patient NNS cord-005453-4057qib7 16136 32 who who WP cord-005453-4057qib7 16136 33 received receive VBD cord-005453-4057qib7 16136 34 cHPC chpc NN cord-005453-4057qib7 16136 35 through through IN cord-005453-4057qib7 16136 36 CVC.Conclusions cvc.conclusion NNS cord-005453-4057qib7 16136 37 : : : cord-005453-4057qib7 16137 1 Based base VBN cord-005453-4057qib7 16137 2 on on IN cord-005453-4057qib7 16137 3 our -PRON- PRP$ cord-005453-4057qib7 16137 4 data datum NNS cord-005453-4057qib7 16137 5 , , , cord-005453-4057qib7 16137 6 we -PRON- PRP cord-005453-4057qib7 16137 7 conclude conclude VBP cord-005453-4057qib7 16137 8 that that IN cord-005453-4057qib7 16137 9 the the DT cord-005453-4057qib7 16137 10 administration administration NN cord-005453-4057qib7 16137 11 of of IN cord-005453-4057qib7 16137 12 cHPC cHPC NNP cord-005453-4057qib7 16137 13 , , , cord-005453-4057qib7 16137 14 through through IN cord-005453-4057qib7 16137 15 PIVC PIVC NNP cord-005453-4057qib7 16137 16 and and CC cord-005453-4057qib7 16137 17 by by IN cord-005453-4057qib7 16137 18 gravity gravity NN cord-005453-4057qib7 16137 19 is be VBZ cord-005453-4057qib7 16137 20 safe safe JJ cord-005453-4057qib7 16137 21 for for IN cord-005453-4057qib7 16137 22 the the DT cord-005453-4057qib7 16137 23 product product NN cord-005453-4057qib7 16137 24 and and CC cord-005453-4057qib7 16137 25 for for IN cord-005453-4057qib7 16137 26 the the DT cord-005453-4057qib7 16137 27 patient patient NN cord-005453-4057qib7 16137 28 , , , cord-005453-4057qib7 16137 29 being be VBG cord-005453-4057qib7 16137 30 the the DT cord-005453-4057qib7 16137 31 preferred preferred JJ cord-005453-4057qib7 16137 32 choice choice NN cord-005453-4057qib7 16137 33 for for IN cord-005453-4057qib7 16137 34 patients patient NNS cord-005453-4057qib7 16137 35 suffering suffer VBG cord-005453-4057qib7 16137 36 from from IN cord-005453-4057qib7 16137 37 some some DT cord-005453-4057qib7 16137 38 type type NN cord-005453-4057qib7 16137 39 of of IN cord-005453-4057qib7 16137 40 cardiovascular cardiovascular JJ cord-005453-4057qib7 16137 41 disease disease NN cord-005453-4057qib7 16137 42 . . . cord-005453-4057qib7 16138 1 Disclosure disclosure NN cord-005453-4057qib7 16138 2 : : : cord-005453-4057qib7 16138 3 Nothing nothing NN cord-005453-4057qib7 16138 4 to to TO cord-005453-4057qib7 16138 5 declare declare VB cord-005453-4057qib7 16138 6 Background background NN cord-005453-4057qib7 16138 7 : : : cord-005453-4057qib7 16139 1 By by IN cord-005453-4057qib7 16139 2 selective selective JJ cord-005453-4057qib7 16139 3 depletion depletion NN cord-005453-4057qib7 16139 4 of of IN cord-005453-4057qib7 16139 5 potentially potentially RB cord-005453-4057qib7 16139 6 alloreactive alloreactive JJ cord-005453-4057qib7 16139 7 CD45RA CD45RA NNP cord-005453-4057qib7 16139 8 + + CC cord-005453-4057qib7 16139 9 cells cell NNS cord-005453-4057qib7 16139 10 , , , cord-005453-4057qib7 16139 11 T T NNP cord-005453-4057qib7 16139 12 memory memory NN cord-005453-4057qib7 16139 13 cells cell NNS cord-005453-4057qib7 16139 14 might may MD cord-005453-4057qib7 16139 15 be be VB cord-005453-4057qib7 16139 16 retained retain VBN cord-005453-4057qib7 16139 17 in in IN cord-005453-4057qib7 16139 18 the the DT cord-005453-4057qib7 16139 19 graft graft NN cord-005453-4057qib7 16139 20 and and CC cord-005453-4057qib7 16139 21 could could MD cord-005453-4057qib7 16139 22 mediate mediate VB cord-005453-4057qib7 16139 23 pathogen pathogen NN cord-005453-4057qib7 16139 24 specific specific JJ cord-005453-4057qib7 16139 25 immunity immunity NN cord-005453-4057qib7 16139 26 . . . cord-005453-4057qib7 16140 1 However however RB cord-005453-4057qib7 16140 2 , , , cord-005453-4057qib7 16140 3 CD45RA cd45ra NN cord-005453-4057qib7 16140 4 expression expression NN cord-005453-4057qib7 16140 5 is be VBZ cord-005453-4057qib7 16140 6 not not RB cord-005453-4057qib7 16140 7 restricted restrict VBN cord-005453-4057qib7 16140 8 to to IN cord-005453-4057qib7 16140 9 naïve naïve JJ cord-005453-4057qib7 16140 10 T t NN cord-005453-4057qib7 16140 11 cells cell NNS cord-005453-4057qib7 16140 12 , , , cord-005453-4057qib7 16140 13 but but CC cord-005453-4057qib7 16140 14 also also RB cord-005453-4057qib7 16140 15 available available JJ cord-005453-4057qib7 16140 16 on on IN cord-005453-4057qib7 16140 17 B b NN cord-005453-4057qib7 16140 18 cells cell NNS cord-005453-4057qib7 16140 19 , , , cord-005453-4057qib7 16140 20 NK NK NNP cord-005453-4057qib7 16140 21 cells cell NNS cord-005453-4057qib7 16140 22 and and CC cord-005453-4057qib7 16140 23 CD34 CD34 NNP cord-005453-4057qib7 16140 24 + + CC cord-005453-4057qib7 16140 25 stem stem NN cord-005453-4057qib7 16140 26 cells cell NNS cord-005453-4057qib7 16140 27 to to IN cord-005453-4057qib7 16140 28 some some DT cord-005453-4057qib7 16140 29 extent extent NN cord-005453-4057qib7 16140 30 . . . cord-005453-4057qib7 16141 1 Methods method NNS cord-005453-4057qib7 16141 2 : : : cord-005453-4057qib7 16141 3 Within within IN cord-005453-4057qib7 16141 4 this this DT cord-005453-4057qib7 16141 5 project project NN cord-005453-4057qib7 16141 6 we -PRON- PRP cord-005453-4057qib7 16141 7 aim aim VBP cord-005453-4057qib7 16141 8 to to TO cord-005453-4057qib7 16141 9 analyze analyze VB cord-005453-4057qib7 16141 10 CD45RA cd45ra NN cord-005453-4057qib7 16141 11 expression expression NN cord-005453-4057qib7 16141 12 on on IN cord-005453-4057qib7 16141 13 stem stem NN cord-005453-4057qib7 16141 14 - - HYPH cord-005453-4057qib7 16141 15 and and CC cord-005453-4057qib7 16141 16 NK NK NNP cord-005453-4057qib7 16141 17 cells cell NNS cord-005453-4057qib7 16141 18 by by IN cord-005453-4057qib7 16141 19 flow flow NN cord-005453-4057qib7 16141 20 cytometric cytometric NNP cord-005453-4057qib7 16141 21 analysis analysis NN cord-005453-4057qib7 16141 22 to to TO cord-005453-4057qib7 16141 23 estimate estimate VB cord-005453-4057qib7 16141 24 the the DT cord-005453-4057qib7 16141 25 eventual eventual JJ cord-005453-4057qib7 16141 26 loss loss NN cord-005453-4057qib7 16141 27 of of IN cord-005453-4057qib7 16141 28 these these DT cord-005453-4057qib7 16141 29 cells cell NNS cord-005453-4057qib7 16141 30 during during IN cord-005453-4057qib7 16141 31 CD45RA cd45ra NN cord-005453-4057qib7 16141 32 - - HYPH cord-005453-4057qib7 16141 33 depletion depletion NN cord-005453-4057qib7 16141 34 . . . cord-005453-4057qib7 16142 1 Furthermore furthermore RB cord-005453-4057qib7 16142 2 , , , cord-005453-4057qib7 16142 3 CliniMACS clinimacs NN cord-005453-4057qib7 16142 4 depletion depletion NN cord-005453-4057qib7 16142 5 following follow VBG cord-005453-4057qib7 16142 6 a a DT cord-005453-4057qib7 16142 7 one one CD cord-005453-4057qib7 16142 8 - - HYPH cord-005453-4057qib7 16142 9 step step NN cord-005453-4057qib7 16142 10 approach approach NN cord-005453-4057qib7 16142 11 of of IN cord-005453-4057qib7 16142 12 direct direct JJ cord-005453-4057qib7 16142 13 CD45RAdepletion CD45RAdepletion NNP cord-005453-4057qib7 16142 14 and and CC cord-005453-4057qib7 16142 15 a a DT cord-005453-4057qib7 16142 16 two two CD cord-005453-4057qib7 16142 17 - - HYPH cord-005453-4057qib7 16142 18 step step NN cord-005453-4057qib7 16142 19 approach approach NN cord-005453-4057qib7 16142 20 with with IN cord-005453-4057qib7 16142 21 primary primary JJ cord-005453-4057qib7 16142 22 CD34selection CD34selection NNP cord-005453-4057qib7 16142 23 followed follow VBN cord-005453-4057qib7 16142 24 by by IN cord-005453-4057qib7 16142 25 CD45RA cd45ra NN cord-005453-4057qib7 16142 26 - - HYPH cord-005453-4057qib7 16142 27 depletion depletion NN cord-005453-4057qib7 16142 28 of of IN cord-005453-4057qib7 16142 29 the the DT cord-005453-4057qib7 16142 30 negative negative JJ cord-005453-4057qib7 16142 31 fraction fraction NN cord-005453-4057qib7 16142 32 was be VBD cord-005453-4057qib7 16142 33 investigated investigate VBN cord-005453-4057qib7 16142 34 . . . cord-005453-4057qib7 16143 1 Results result NNS cord-005453-4057qib7 16143 2 : : : cord-005453-4057qib7 16143 3 CD45RA cd45ra NN cord-005453-4057qib7 16143 4 expression expression NN cord-005453-4057qib7 16143 5 on on IN cord-005453-4057qib7 16143 6 CD34 CD34 NNP cord-005453-4057qib7 16143 7 + + CC cord-005453-4057qib7 16143 8 stem stem NN cord-005453-4057qib7 16143 9 cells cell NNS cord-005453-4057qib7 16143 10 was be VBD cord-005453-4057qib7 16143 11 in in IN cord-005453-4057qib7 16143 12 median median JJ cord-005453-4057qib7 16143 13 16.9 16.9 CD cord-005453-4057qib7 16143 14 % % NN cord-005453-4057qib7 16143 15 . . . cord-005453-4057qib7 16144 1 With with IN cord-005453-4057qib7 16144 2 a a DT cord-005453-4057qib7 16144 3 Median Median NNP cord-005453-4057qib7 16144 4 of of IN cord-005453-4057qib7 16144 5 99.4 99.4 CD cord-005453-4057qib7 16144 6 % % NN cord-005453-4057qib7 16144 7 CD45RA cd45ra NN cord-005453-4057qib7 16144 8 expression expression NN cord-005453-4057qib7 16144 9 was be VBD cord-005453-4057qib7 16144 10 measurable measurable JJ cord-005453-4057qib7 16144 11 on on IN cord-005453-4057qib7 16144 12 nearly nearly RB cord-005453-4057qib7 16144 13 all all DT cord-005453-4057qib7 16144 14 B b NN cord-005453-4057qib7 16144 15 cells cell NNS cord-005453-4057qib7 16144 16 , , , cord-005453-4057qib7 16144 17 which which WDT cord-005453-4057qib7 16144 18 obviates obviate VBZ cord-005453-4057qib7 16144 19 depletion depletion NN cord-005453-4057qib7 16144 20 via via IN cord-005453-4057qib7 16144 21 CD19 CD19 NNP cord-005453-4057qib7 16144 22 . . . cord-005453-4057qib7 16145 1 A a DT cord-005453-4057qib7 16145 2 comparably comparably RB cord-005453-4057qib7 16145 3 high high JJ cord-005453-4057qib7 16145 4 CD45RA cd45ra NN cord-005453-4057qib7 16145 5 expression expression NN cord-005453-4057qib7 16145 6 of of IN cord-005453-4057qib7 16145 7 in in IN cord-005453-4057qib7 16145 8 median median JJ cord-005453-4057qib7 16145 9 96.0 96.0 CD cord-005453-4057qib7 16145 10 % % NN cord-005453-4057qib7 16145 11 was be VBD cord-005453-4057qib7 16145 12 detected detect VBN cord-005453-4057qib7 16145 13 on on IN cord-005453-4057qib7 16145 14 NK NK NNP cord-005453-4057qib7 16145 15 cells cell NNS cord-005453-4057qib7 16145 16 . . . cord-005453-4057qib7 16146 1 Unfortunately unfortunately RB cord-005453-4057qib7 16146 2 , , , cord-005453-4057qib7 16146 3 the the DT cord-005453-4057qib7 16146 4 amount amount NN cord-005453-4057qib7 16146 5 of of IN cord-005453-4057qib7 16146 6 NK NK NNP cord-005453-4057qib7 16146 7 cells cell NNS cord-005453-4057qib7 16146 8 in in IN cord-005453-4057qib7 16146 9 the the DT cord-005453-4057qib7 16146 10 CD45RA cd45ra NN cord-005453-4057qib7 16146 11 - - HYPH cord-005453-4057qib7 16146 12 depleted deplete VBN cord-005453-4057qib7 16146 13 product product NN cord-005453-4057qib7 16146 14 was be VBD cord-005453-4057qib7 16146 15 0.24 0.24 CD cord-005453-4057qib7 16146 16 % % NN cord-005453-4057qib7 16146 17 . . . cord-005453-4057qib7 16147 1 CliniMACS clinimacs NN cord-005453-4057qib7 16147 2 depletion depletion NN cord-005453-4057qib7 16147 3 following follow VBG cord-005453-4057qib7 16147 4 one one CD cord-005453-4057qib7 16147 5 - - HYPH cord-005453-4057qib7 16147 6 step step NN cord-005453-4057qib7 16147 7 approach approach NN cord-005453-4057qib7 16147 8 resulted result VBD cord-005453-4057qib7 16147 9 in in IN cord-005453-4057qib7 16147 10 a a DT cord-005453-4057qib7 16147 11 stem stem NN cord-005453-4057qib7 16147 12 cell cell NN cord-005453-4057qib7 16147 13 recovery recovery NN cord-005453-4057qib7 16147 14 of of IN cord-005453-4057qib7 16147 15 52.0 52.0 CD cord-005453-4057qib7 16147 16 % % NN cord-005453-4057qib7 16147 17 . . . cord-005453-4057qib7 16148 1 Memory memory NN cord-005453-4057qib7 16148 2 T t CD cord-005453-4057qib7 16148 3 cell cell NN cord-005453-4057qib7 16148 4 recovery recovery NN cord-005453-4057qib7 16148 5 was be VBD cord-005453-4057qib7 16148 6 24.2 24.2 CD cord-005453-4057qib7 16148 7 % % NN cord-005453-4057qib7 16148 8 following follow VBG cord-005453-4057qib7 16148 9 one one CD cord-005453-4057qib7 16148 10 - - HYPH cord-005453-4057qib7 16148 11 step step NN cord-005453-4057qib7 16148 12 and and CC cord-005453-4057qib7 16148 13 42.0 42.0 CD cord-005453-4057qib7 16148 14 % % NN cord-005453-4057qib7 16148 15 applying apply VBG cord-005453-4057qib7 16148 16 two two CD cord-005453-4057qib7 16148 17 - - HYPH cord-005453-4057qib7 16148 18 step step NN cord-005453-4057qib7 16148 19 approach approach NN cord-005453-4057qib7 16148 20 . . . cord-005453-4057qib7 16149 1 Depletion depletion NN cord-005453-4057qib7 16149 2 quality quality NN cord-005453-4057qib7 16149 3 measured measure VBN cord-005453-4057qib7 16149 4 by by IN cord-005453-4057qib7 16149 5 log log NN cord-005453-4057qib7 16149 6 - - HYPH cord-005453-4057qib7 16149 7 depletion depletion NN cord-005453-4057qib7 16149 8 was be VBD cord-005453-4057qib7 16149 9 3.9 3.9 CD cord-005453-4057qib7 16149 10 and and CC cord-005453-4057qib7 16149 11 3.8 3.8 CD cord-005453-4057qib7 16149 12 for for IN cord-005453-4057qib7 16149 13 CD45RA cd45ra NN cord-005453-4057qib7 16149 14 + + CC cord-005453-4057qib7 16149 15 T t NN cord-005453-4057qib7 16149 16 cells cell NNS cord-005453-4057qib7 16149 17 and and CC cord-005453-4057qib7 16149 18 3.2 3.2 CD cord-005453-4057qib7 16149 19 and and CC cord-005453-4057qib7 16149 20 3.6 3.6 CD cord-005453-4057qib7 16149 21 for for IN cord-005453-4057qib7 16149 22 CD19 CD19 NNP cord-005453-4057qib7 16149 23 + + CC cord-005453-4057qib7 16149 24 B b NN cord-005453-4057qib7 16149 25 cells cell NNS cord-005453-4057qib7 16149 26 for for IN cord-005453-4057qib7 16149 27 one one CD cord-005453-4057qib7 16149 28 - - HYPH cord-005453-4057qib7 16149 29 and and CC cord-005453-4057qib7 16149 30 two two CD cord-005453-4057qib7 16149 31 - - HYPH cord-005453-4057qib7 16149 32 step step NN cord-005453-4057qib7 16149 33 approaches approach NNS cord-005453-4057qib7 16149 34 , , , cord-005453-4057qib7 16149 35 respectively respectively RB cord-005453-4057qib7 16149 36 . . . cord-005453-4057qib7 16150 1 Conclusions conclusion NNS cord-005453-4057qib7 16150 2 : : : cord-005453-4057qib7 16150 3 With with IN cord-005453-4057qib7 16150 4 regard regard NN cord-005453-4057qib7 16150 5 to to IN cord-005453-4057qib7 16150 6 stem stem VB cord-005453-4057qib7 16150 7 cell cell NN cord-005453-4057qib7 16150 8 recovery recovery NN cord-005453-4057qib7 16150 9 , , , cord-005453-4057qib7 16150 10 a a DT cord-005453-4057qib7 16150 11 previous previous JJ cord-005453-4057qib7 16150 12 CD34-selection cd34-selection NN cord-005453-4057qib7 16150 13 before before IN cord-005453-4057qib7 16150 14 CD45RA cd45ra NN cord-005453-4057qib7 16150 15 - - HYPH cord-005453-4057qib7 16150 16 depletion depletion NN cord-005453-4057qib7 16150 17 is be VBZ cord-005453-4057qib7 16150 18 recommendable recommendable JJ cord-005453-4057qib7 16150 19 . . . cord-005453-4057qib7 16151 1 Background background NN cord-005453-4057qib7 16151 2 : : : cord-005453-4057qib7 16152 1 Current current JJ cord-005453-4057qib7 16152 2 clinical clinical JJ cord-005453-4057qib7 16152 3 practice practice NN cord-005453-4057qib7 16152 4 of of IN cord-005453-4057qib7 16152 5 routine routine JJ cord-005453-4057qib7 16152 6 use use NN cord-005453-4057qib7 16152 7 of of IN cord-005453-4057qib7 16152 8 filters filter NNS cord-005453-4057qib7 16152 9 for for IN cord-005453-4057qib7 16152 10 infusion infusion NN cord-005453-4057qib7 16152 11 of of IN cord-005453-4057qib7 16152 12 autologous autologous JJ cord-005453-4057qib7 16152 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 16152 14 cell cell NN cord-005453-4057qib7 16152 15 transplantation transplantation NN cord-005453-4057qib7 16152 16 ( ( -LRB- cord-005453-4057qib7 16152 17 AHCT AHCT NNP cord-005453-4057qib7 16152 18 ) ) -RRB- cord-005453-4057qib7 16152 19 at at IN cord-005453-4057qib7 16152 20 bone bone NN cord-005453-4057qib7 16152 21 marrow marrow NN cord-005453-4057qib7 16152 22 transplant transplant NN cord-005453-4057qib7 16152 23 centers center NNS cord-005453-4057qib7 16152 24 across across IN cord-005453-4057qib7 16152 25 North North NNP cord-005453-4057qib7 16152 26 America America NNP cord-005453-4057qib7 16152 27 and and CC cord-005453-4057qib7 16152 28 Europe Europe NNP cord-005453-4057qib7 16152 29 is be VBZ cord-005453-4057qib7 16152 30 not not RB cord-005453-4057qib7 16152 31 known know VBN cord-005453-4057qib7 16152 32 . . . cord-005453-4057qib7 16153 1 The the DT cord-005453-4057qib7 16153 2 use use NN cord-005453-4057qib7 16153 3 of of IN cord-005453-4057qib7 16153 4 " " `` cord-005453-4057qib7 16153 5 Y Y NNP cord-005453-4057qib7 16153 6 " " '' cord-005453-4057qib7 16153 7 administration administration NN cord-005453-4057qib7 16153 8 tubing tubing NN cord-005453-4057qib7 16153 9 without without IN cord-005453-4057qib7 16153 10 a a DT cord-005453-4057qib7 16153 11 filter filter NN cord-005453-4057qib7 16153 12 could could MD cord-005453-4057qib7 16153 13 possibly possibly RB cord-005453-4057qib7 16153 14 increase increase VB cord-005453-4057qib7 16153 15 the the DT cord-005453-4057qib7 16153 16 risk risk NN cord-005453-4057qib7 16153 17 of of IN cord-005453-4057qib7 16153 18 infusion infusion NN cord-005453-4057qib7 16153 19 of of IN cord-005453-4057qib7 16153 20 macro macro NN cord-005453-4057qib7 16153 21 - - HYPH cord-005453-4057qib7 16153 22 aggregates aggregate NNS cord-005453-4057qib7 16153 23 and and CC cord-005453-4057qib7 16153 24 cellular cellular JJ cord-005453-4057qib7 16153 25 debris debris NN cord-005453-4057qib7 16153 26 , , , cord-005453-4057qib7 16153 27 which which WDT cord-005453-4057qib7 16153 28 may may MD cord-005453-4057qib7 16153 29 result result VB cord-005453-4057qib7 16153 30 in in IN cord-005453-4057qib7 16153 31 increased increase VBN cord-005453-4057qib7 16153 32 side side NN cord-005453-4057qib7 16153 33 effects effect NNS cord-005453-4057qib7 16153 34 . . . cord-005453-4057qib7 16154 1 Methods method NNS cord-005453-4057qib7 16154 2 : : : cord-005453-4057qib7 16154 3 We -PRON- PRP cord-005453-4057qib7 16154 4 carried carry VBD cord-005453-4057qib7 16154 5 out out RP cord-005453-4057qib7 16154 6 a a DT cord-005453-4057qib7 16154 7 retrospective retrospective JJ cord-005453-4057qib7 16154 8 chart chart NN cord-005453-4057qib7 16154 9 review review NN cord-005453-4057qib7 16154 10 of of IN cord-005453-4057qib7 16154 11 patients patient NNS cord-005453-4057qib7 16154 12 ( ( -LRB- cord-005453-4057qib7 16154 13 pts pts NN cord-005453-4057qib7 16154 14 ) ) -RRB- cord-005453-4057qib7 16154 15 at at IN cord-005453-4057qib7 16154 16 Spectrum Spectrum NNP cord-005453-4057qib7 16154 17 Health Health NNP cord-005453-4057qib7 16154 18 who who WP cord-005453-4057qib7 16154 19 underwent undergo VBD cord-005453-4057qib7 16154 20 AHCT AHCT NNP cord-005453-4057qib7 16154 21 . . . cord-005453-4057qib7 16155 1 Group Group NNP cord-005453-4057qib7 16155 2 A A NNP cord-005453-4057qib7 16155 3 ( ( -LRB- cord-005453-4057qib7 16155 4 Gp Gp NNP cord-005453-4057qib7 16155 5 A A NNP cord-005453-4057qib7 16155 6 ) ) -RRB- cord-005453-4057qib7 16155 7 pts pts NN cord-005453-4057qib7 16155 8 received receive VBD cord-005453-4057qib7 16155 9 AHCT AHCT NNP cord-005453-4057qib7 16155 10 using use VBG cord-005453-4057qib7 16155 11 a a DT cord-005453-4057qib7 16155 12 " " `` cord-005453-4057qib7 16155 13 Y Y NNP cord-005453-4057qib7 16155 14 " " '' cord-005453-4057qib7 16155 15 administration administration NN cord-005453-4057qib7 16155 16 tubing tubing NN cord-005453-4057qib7 16155 17 with with IN cord-005453-4057qib7 16155 18 170-micron 170-micron CD cord-005453-4057qib7 16155 19 filter filter NN cord-005453-4057qib7 16155 20 from from IN cord-005453-4057qib7 16155 21 3/2013 3/2013 CD cord-005453-4057qib7 16155 22 -3/2017 -3/2017 NFP cord-005453-4057qib7 16155 23 . . . cord-005453-4057qib7 16156 1 These these DT cord-005453-4057qib7 16156 2 patients patient NNS cord-005453-4057qib7 16156 3 were be VBD cord-005453-4057qib7 16156 4 compared compare VBN cord-005453-4057qib7 16156 5 to to IN cord-005453-4057qib7 16156 6 a a DT cord-005453-4057qib7 16156 7 control control NN cord-005453-4057qib7 16156 8 group group NN cord-005453-4057qib7 16156 9 ( ( -LRB- cord-005453-4057qib7 16156 10 Gp Gp NNP cord-005453-4057qib7 16156 11 B B NNP cord-005453-4057qib7 16156 12 ) ) -RRB- cord-005453-4057qib7 16156 13 that that WDT cord-005453-4057qib7 16156 14 received receive VBD cord-005453-4057qib7 16156 15 AHCT AHCT NNP cord-005453-4057qib7 16156 16 without without IN cord-005453-4057qib7 16156 17 filter filter NN cord-005453-4057qib7 16156 18 administration administration NN cord-005453-4057qib7 16156 19 tubing tubing NN cord-005453-4057qib7 16156 20 from from IN cord-005453-4057qib7 16156 21 3/2014 3/2014 CD cord-005453-4057qib7 16156 22 - - : cord-005453-4057qib7 16156 23 4/2016.This 4/2016.this CD cord-005453-4057qib7 16156 24 change change NN cord-005453-4057qib7 16156 25 in in IN cord-005453-4057qib7 16156 26 clinical clinical JJ cord-005453-4057qib7 16156 27 practice practice NN cord-005453-4057qib7 16156 28 occurred occur VBD cord-005453-4057qib7 16156 29 due due IN cord-005453-4057qib7 16156 30 to to IN cord-005453-4057qib7 16156 31 a a DT cord-005453-4057qib7 16156 32 change change NN cord-005453-4057qib7 16156 33 in in IN cord-005453-4057qib7 16156 34 policy policy NN cord-005453-4057qib7 16156 35 at at IN cord-005453-4057qib7 16156 36 our -PRON- PRP$ cord-005453-4057qib7 16156 37 transplant transplant NN cord-005453-4057qib7 16156 38 center center NN cord-005453-4057qib7 16156 39 as as IN cord-005453-4057qib7 16156 40 a a DT cord-005453-4057qib7 16156 41 result result NN cord-005453-4057qib7 16156 42 of of IN cord-005453-4057qib7 16156 43 inorganic inorganic JJ cord-005453-4057qib7 16156 44 particles particle NNS cord-005453-4057qib7 16156 45 noticed notice VBN cord-005453-4057qib7 16156 46 during during IN cord-005453-4057qib7 16156 47 cryopreservation cryopreservation NN cord-005453-4057qib7 16156 48 . . . cord-005453-4057qib7 16157 1 We -PRON- PRP cord-005453-4057qib7 16157 2 compared compare VBD cord-005453-4057qib7 16157 3 the the DT cord-005453-4057qib7 16157 4 neutrophil neutrophil NN cord-005453-4057qib7 16157 5 and and CC cord-005453-4057qib7 16157 6 platelet platelet NN cord-005453-4057qib7 16157 7 engraftment engraftment NN cord-005453-4057qib7 16157 8 duration duration NN cord-005453-4057qib7 16157 9 between between IN cord-005453-4057qib7 16157 10 these these DT cord-005453-4057qib7 16157 11 groups group NNS cord-005453-4057qib7 16157 12 . . . cord-005453-4057qib7 16158 1 We -PRON- PRP cord-005453-4057qib7 16158 2 also also RB cord-005453-4057qib7 16158 3 studied study VBD cord-005453-4057qib7 16158 4 the the DT cord-005453-4057qib7 16158 5 length length NN cord-005453-4057qib7 16158 6 of of IN cord-005453-4057qib7 16158 7 hospital hospital NN cord-005453-4057qib7 16158 8 stay stay NN cord-005453-4057qib7 16158 9 and and CC cord-005453-4057qib7 16158 10 the the DT cord-005453-4057qib7 16158 11 effect effect NN cord-005453-4057qib7 16158 12 of of IN cord-005453-4057qib7 16158 13 filter filter NN cord-005453-4057qib7 16158 14 use use NN cord-005453-4057qib7 16158 15 on on IN cord-005453-4057qib7 16158 16 any any DT cord-005453-4057qib7 16158 17 immediate immediate JJ cord-005453-4057qib7 16158 18 side side NN cord-005453-4057qib7 16158 19 effects effect NNS cord-005453-4057qib7 16158 20 after after IN cord-005453-4057qib7 16158 21 infusion infusion NN cord-005453-4057qib7 16158 22 . . . cord-005453-4057qib7 16159 1 Due due IN cord-005453-4057qib7 16159 2 to to IN cord-005453-4057qib7 16159 3 the the DT cord-005453-4057qib7 16159 4 retrospective retrospective JJ cord-005453-4057qib7 16159 5 nature nature NN cord-005453-4057qib7 16159 6 of of IN cord-005453-4057qib7 16159 7 the the DT cord-005453-4057qib7 16159 8 study study NN cord-005453-4057qib7 16159 9 it -PRON- PRP cord-005453-4057qib7 16159 10 was be VBD cord-005453-4057qib7 16159 11 not not RB cord-005453-4057qib7 16159 12 feasible feasible JJ cord-005453-4057qib7 16159 13 to to TO cord-005453-4057qib7 16159 14 evaluate evaluate VB cord-005453-4057qib7 16159 15 the the DT cord-005453-4057qib7 16159 16 difference difference NN cord-005453-4057qib7 16159 17 in in IN cord-005453-4057qib7 16159 18 duration duration NN cord-005453-4057qib7 16159 19 of of IN cord-005453-4057qib7 16159 20 infusion infusion NN cord-005453-4057qib7 16159 21 between between IN cord-005453-4057qib7 16159 22 these these DT cord-005453-4057qib7 16159 23 groups group NNS cord-005453-4057qib7 16159 24 Results result NNS cord-005453-4057qib7 16159 25 : : : cord-005453-4057qib7 16160 1 The the DT cord-005453-4057qib7 16160 2 two two CD cord-005453-4057qib7 16160 3 groups group NNS cord-005453-4057qib7 16160 4 were be VBD cord-005453-4057qib7 16160 5 similar similar JJ cord-005453-4057qib7 16160 6 in in IN cord-005453-4057qib7 16160 7 their -PRON- PRP$ cord-005453-4057qib7 16160 8 age age NN cord-005453-4057qib7 16160 9 , , , cord-005453-4057qib7 16160 10 gender gender NN cord-005453-4057qib7 16160 11 , , , cord-005453-4057qib7 16160 12 primary primary JJ cord-005453-4057qib7 16160 13 disease disease NN cord-005453-4057qib7 16160 14 distribution distribution NN cord-005453-4057qib7 16160 15 and and CC cord-005453-4057qib7 16160 16 median median JJ cord-005453-4057qib7 16160 17 number number NN cord-005453-4057qib7 16160 18 of of IN cord-005453-4057qib7 16160 19 CD34 CD34 NNP cord-005453-4057qib7 16160 20 stem stem NN cord-005453-4057qib7 16160 21 cells cell NNS cord-005453-4057qib7 16160 22 infused infuse VBN cord-005453-4057qib7 16160 23 ( ( -LRB- cord-005453-4057qib7 16160 24 Table table NN cord-005453-4057qib7 16160 25 ) ) -RRB- cord-005453-4057qib7 16160 26 . . . cord-005453-4057qib7 16161 1 There there EX cord-005453-4057qib7 16161 2 was be VBD cord-005453-4057qib7 16161 3 no no DT cord-005453-4057qib7 16161 4 difference difference NN cord-005453-4057qib7 16161 5 in in IN cord-005453-4057qib7 16161 6 median median JJ cord-005453-4057qib7 16161 7 neutrophil neutrophil NN cord-005453-4057qib7 16161 8 ( ( -LRB- cord-005453-4057qib7 16161 9 11 11 CD cord-005453-4057qib7 16161 10 vs vs IN cord-005453-4057qib7 16161 11 11 11 CD cord-005453-4057qib7 16161 12 days day NNS cord-005453-4057qib7 16161 13 ) ) -RRB- cord-005453-4057qib7 16161 14 or or CC cord-005453-4057qib7 16161 15 platelet platelet NN cord-005453-4057qib7 16161 16 engraftment engraftment NN cord-005453-4057qib7 16161 17 ( ( -LRB- cord-005453-4057qib7 16161 18 19 19 CD cord-005453-4057qib7 16161 19 vs vs IN cord-005453-4057qib7 16161 20 19 19 CD cord-005453-4057qib7 16161 21 days day NNS cord-005453-4057qib7 16161 22 ) ) -RRB- cord-005453-4057qib7 16161 23 duration duration NN cord-005453-4057qib7 16161 24 for for IN cord-005453-4057qib7 16161 25 the the DT cord-005453-4057qib7 16161 26 filter filter NN cord-005453-4057qib7 16161 27 group group NN cord-005453-4057qib7 16161 28 and and CC cord-005453-4057qib7 16161 29 the the DT cord-005453-4057qib7 16161 30 nonfilter nonfilter NNP cord-005453-4057qib7 16161 31 group group NNP cord-005453-4057qib7 16161 32 respectively respectively RB cord-005453-4057qib7 16161 33 . . . cord-005453-4057qib7 16162 1 The the DT cord-005453-4057qib7 16162 2 median median JJ cord-005453-4057qib7 16162 3 length length NN cord-005453-4057qib7 16162 4 of of IN cord-005453-4057qib7 16162 5 hospital hospital NN cord-005453-4057qib7 16162 6 stay stay NN cord-005453-4057qib7 16162 7 was be VBD cord-005453-4057qib7 16162 8 also also RB cord-005453-4057qib7 16162 9 comparable comparable JJ cord-005453-4057qib7 16162 10 ( ( -LRB- cord-005453-4057qib7 16162 11 17 17 CD cord-005453-4057qib7 16162 12 days day NNS cord-005453-4057qib7 16162 13 ) ) -RRB- cord-005453-4057qib7 16162 14 . . . cord-005453-4057qib7 16163 1 There there EX cord-005453-4057qib7 16163 2 was be VBD cord-005453-4057qib7 16163 3 no no DT cord-005453-4057qib7 16163 4 statistically statistically RB cord-005453-4057qib7 16163 5 significant significant JJ cord-005453-4057qib7 16163 6 difference difference NN cord-005453-4057qib7 16163 7 in in IN cord-005453-4057qib7 16163 8 the the DT cord-005453-4057qib7 16163 9 immediate immediate JJ cord-005453-4057qib7 16163 10 side side NN cord-005453-4057qib7 16163 11 effects effect NNS cord-005453-4057qib7 16163 12 ( ( -LRB- cord-005453-4057qib7 16163 13 fever fever NN cord-005453-4057qib7 16163 14 , , , cord-005453-4057qib7 16163 15 cough cough NN cord-005453-4057qib7 16163 16 , , , cord-005453-4057qib7 16163 17 dyspnea dyspnea NN cord-005453-4057qib7 16163 18 , , , cord-005453-4057qib7 16163 19 fluid fluid JJ cord-005453-4057qib7 16163 20 overload overload NN cord-005453-4057qib7 16163 21 , , , cord-005453-4057qib7 16163 22 flushing flushing NN cord-005453-4057qib7 16163 23 , , , cord-005453-4057qib7 16163 24 nausea nausea NN cord-005453-4057qib7 16163 25 , , , cord-005453-4057qib7 16163 26 vomiting vomiting NN cord-005453-4057qib7 16163 27 , , , cord-005453-4057qib7 16163 28 hypertension hypertension NN cord-005453-4057qib7 16163 29 , , , cord-005453-4057qib7 16163 30 hypotension hypotension NN cord-005453-4057qib7 16163 31 and and CC cord-005453-4057qib7 16163 32 anaphylaxis anaphylaxis NN cord-005453-4057qib7 16163 33 ) ) -RRB- cord-005453-4057qib7 16163 34 or or CC cord-005453-4057qib7 16163 35 confirmed confirm VBD cord-005453-4057qib7 16163 36 post post JJ cord-005453-4057qib7 16163 37 - - JJ cord-005453-4057qib7 16163 38 transplant transplant JJ cord-005453-4057qib7 16163 39 infections infection NNS cord-005453-4057qib7 16163 40 ( ( -LRB- cord-005453-4057qib7 16163 41 viral viral JJ cord-005453-4057qib7 16163 42 , , , cord-005453-4057qib7 16163 43 bacterial bacterial JJ cord-005453-4057qib7 16163 44 , , , cord-005453-4057qib7 16163 45 fungal fungal NN cord-005453-4057qib7 16163 46 ) ) -RRB- cord-005453-4057qib7 16163 47 experienced experience VBN cord-005453-4057qib7 16163 48 by by IN cord-005453-4057qib7 16163 49 these these DT cord-005453-4057qib7 16163 50 two two CD cord-005453-4057qib7 16163 51 groups group NNS cord-005453-4057qib7 16163 52 . . . cord-005453-4057qib7 16164 1 Conclusions conclusion NNS cord-005453-4057qib7 16164 2 : : : cord-005453-4057qib7 16165 1 Our -PRON- PRP$ cord-005453-4057qib7 16165 2 results result NNS cord-005453-4057qib7 16165 3 show show VBP cord-005453-4057qib7 16165 4 that that IN cord-005453-4057qib7 16165 5 the the DT cord-005453-4057qib7 16165 6 routine routine JJ cord-005453-4057qib7 16165 7 use use NN cord-005453-4057qib7 16165 8 of of IN cord-005453-4057qib7 16165 9 filter filter NN cord-005453-4057qib7 16165 10 does do VBZ cord-005453-4057qib7 16165 11 not not RB cord-005453-4057qib7 16165 12 prolong prolong VB cord-005453-4057qib7 16165 13 hospital hospital NN cord-005453-4057qib7 16165 14 stay stay NN cord-005453-4057qib7 16165 15 , , , cord-005453-4057qib7 16165 16 and and CC cord-005453-4057qib7 16165 17 neutrophil/ neutrophil/ CD cord-005453-4057qib7 16165 18 platelet platelet NN cord-005453-4057qib7 16165 19 engraftment engraftment NN cord-005453-4057qib7 16165 20 duration duration NN cord-005453-4057qib7 16165 21 , , , cord-005453-4057qib7 16165 22 thereby thereby RB cord-005453-4057qib7 16165 23 , , , cord-005453-4057qib7 16165 24 suggesting suggest VBG cord-005453-4057qib7 16165 25 that that IN cord-005453-4057qib7 16165 26 viable viable JJ cord-005453-4057qib7 16165 27 stem stem NN cord-005453-4057qib7 16165 28 cells cell NNS cord-005453-4057qib7 16165 29 are be VBP cord-005453-4057qib7 16165 30 not not RB cord-005453-4057qib7 16165 31 affected affect VBN cord-005453-4057qib7 16165 32 . . . cord-005453-4057qib7 16166 1 On on IN cord-005453-4057qib7 16166 2 the the DT cord-005453-4057qib7 16166 3 other other JJ cord-005453-4057qib7 16166 4 hand hand NN cord-005453-4057qib7 16166 5 , , , cord-005453-4057qib7 16166 6 filter filter NN cord-005453-4057qib7 16166 7 use use NN cord-005453-4057qib7 16166 8 failed fail VBD cord-005453-4057qib7 16166 9 to to TO cord-005453-4057qib7 16166 10 demonstrate demonstrate VB cord-005453-4057qib7 16166 11 any any DT cord-005453-4057qib7 16166 12 appreciable appreciable JJ cord-005453-4057qib7 16166 13 decline decline NN cord-005453-4057qib7 16166 14 in in IN cord-005453-4057qib7 16166 15 the the DT cord-005453-4057qib7 16166 16 immediate immediate JJ cord-005453-4057qib7 16166 17 side side NN cord-005453-4057qib7 16166 18 effects effect NNS cord-005453-4057qib7 16166 19 experienced experience VBN cord-005453-4057qib7 16166 20 after after IN cord-005453-4057qib7 16166 21 AHCT AHCT NNP cord-005453-4057qib7 16166 22 . . . cord-005453-4057qib7 16167 1 Gp Gp NNP cord-005453-4057qib7 16167 2 Background background NN cord-005453-4057qib7 16167 3 : : : cord-005453-4057qib7 16167 4 Allo Allo NNP cord-005453-4057qib7 16167 5 - - HYPH cord-005453-4057qib7 16167 6 HSCT HSCT NNP cord-005453-4057qib7 16167 7 from from IN cord-005453-4057qib7 16167 8 related related JJ cord-005453-4057qib7 16167 9 haplo haplo NN cord-005453-4057qib7 16167 10 - - HYPH cord-005453-4057qib7 16167 11 identical identical JJ cord-005453-4057qib7 16167 12 donors donor NNS cord-005453-4057qib7 16167 13 ( ( -LRB- cord-005453-4057qib7 16167 14 Haplo Haplo NNP cord-005453-4057qib7 16167 15 - - HYPH cord-005453-4057qib7 16167 16 HSCT HSCT NNP cord-005453-4057qib7 16167 17 ) ) -RRB- cord-005453-4057qib7 16167 18 with with IN cord-005453-4057qib7 16167 19 post post JJ cord-005453-4057qib7 16167 20 - - JJ cord-005453-4057qib7 16167 21 transplant transplant JJ cord-005453-4057qib7 16167 22 high high JJ cord-005453-4057qib7 16167 23 - - HYPH cord-005453-4057qib7 16167 24 dose dose NN cord-005453-4057qib7 16167 25 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 16167 26 is be VBZ cord-005453-4057qib7 16167 27 increasingly increasingly RB cord-005453-4057qib7 16167 28 employed employ VBN cord-005453-4057qib7 16167 29 in in IN cord-005453-4057qib7 16167 30 patients patient NNS cord-005453-4057qib7 16167 31 who who WP cord-005453-4057qib7 16167 32 lack lack VBP cord-005453-4057qib7 16167 33 a a DT cord-005453-4057qib7 16167 34 matched match VBN cord-005453-4057qib7 16167 35 related related JJ cord-005453-4057qib7 16167 36 or or CC cord-005453-4057qib7 16167 37 unrelated unrelated JJ cord-005453-4057qib7 16167 38 donor donor NN cord-005453-4057qib7 16167 39 . . . cord-005453-4057qib7 16168 1 The the DT cord-005453-4057qib7 16168 2 current current JJ cord-005453-4057qib7 16168 3 standard standard NN cord-005453-4057qib7 16168 4 is be VBZ cord-005453-4057qib7 16168 5 to to TO cord-005453-4057qib7 16168 6 use use VB cord-005453-4057qib7 16168 7 bone bone NN cord-005453-4057qib7 16168 8 marrow marrow NN cord-005453-4057qib7 16168 9 grafts graft NNS cord-005453-4057qib7 16168 10 ( ( -LRB- cord-005453-4057qib7 16168 11 BM BM NNP cord-005453-4057qib7 16168 12 ) ) -RRB- cord-005453-4057qib7 16168 13 as as IN cord-005453-4057qib7 16168 14 peripheral peripheral JJ cord-005453-4057qib7 16168 15 blood blood NN cord-005453-4057qib7 16168 16 stem stem NN cord-005453-4057qib7 16168 17 cell cell NN cord-005453-4057qib7 16168 18 grafts graft NNS cord-005453-4057qib7 16168 19 ( ( -LRB- cord-005453-4057qib7 16168 20 PBSC PBSC NNP cord-005453-4057qib7 16168 21 ) ) -RRB- cord-005453-4057qib7 16168 22 have have VBP cord-005453-4057qib7 16168 23 been be VBN cord-005453-4057qib7 16168 24 associated associate VBN cord-005453-4057qib7 16168 25 with with IN cord-005453-4057qib7 16168 26 an an DT cord-005453-4057qib7 16168 27 increased increase VBN cord-005453-4057qib7 16168 28 risk risk NN cord-005453-4057qib7 16168 29 of of IN cord-005453-4057qib7 16168 30 acute acute JJ cord-005453-4057qib7 16168 31 and and CC cord-005453-4057qib7 16168 32 chronic chronic JJ cord-005453-4057qib7 16168 33 GvHD GvHD NNP cord-005453-4057qib7 16168 34 . . . cord-005453-4057qib7 16169 1 Thus thus RB cord-005453-4057qib7 16169 2 , , , cord-005453-4057qib7 16169 3 the the DT cord-005453-4057qib7 16169 4 aim aim NN cord-005453-4057qib7 16169 5 of of IN cord-005453-4057qib7 16169 6 our -PRON- PRP$ cord-005453-4057qib7 16169 7 study study NN cord-005453-4057qib7 16169 8 was be VBD cord-005453-4057qib7 16169 9 to to TO cord-005453-4057qib7 16169 10 compare compare VB cord-005453-4057qib7 16169 11 the the DT cord-005453-4057qib7 16169 12 main main JJ cord-005453-4057qib7 16169 13 transplant transplant NN cord-005453-4057qib7 16169 14 outcomes outcome NNS cord-005453-4057qib7 16169 15 and and CC cord-005453-4057qib7 16169 16 especially especially RB cord-005453-4057qib7 16169 17 the the DT cord-005453-4057qib7 16169 18 incidence incidence NN cord-005453-4057qib7 16169 19 of of IN cord-005453-4057qib7 16169 20 acute acute JJ cord-005453-4057qib7 16169 21 and and CC cord-005453-4057qib7 16169 22 chronic chronic JJ cord-005453-4057qib7 16169 23 GVHD GVHD NNP cord-005453-4057qib7 16169 24 in in IN cord-005453-4057qib7 16169 25 recipients recipient NNS cord-005453-4057qib7 16169 26 of of IN cord-005453-4057qib7 16169 27 BM BM NNP cord-005453-4057qib7 16169 28 and and CC cord-005453-4057qib7 16169 29 PBSC PBSC NNP cord-005453-4057qib7 16169 30 grafts graft NNS cord-005453-4057qib7 16169 31 . . . cord-005453-4057qib7 16170 1 Methods method NNS cord-005453-4057qib7 16170 2 : : : cord-005453-4057qib7 16171 1 Thirty thirty CD cord-005453-4057qib7 16171 2 - - HYPH cord-005453-4057qib7 16171 3 five five CD cord-005453-4057qib7 16171 4 unselected unselected JJ cord-005453-4057qib7 16171 5 patients patient NNS cord-005453-4057qib7 16171 6 with with IN cord-005453-4057qib7 16171 7 hematologic hematologic JJ cord-005453-4057qib7 16171 8 malignancy malignancy NN cord-005453-4057qib7 16171 9 who who WP cord-005453-4057qib7 16171 10 underwent undergo VBD cord-005453-4057qib7 16171 11 an an DT cord-005453-4057qib7 16171 12 haploidentical haploidentical JJ cord-005453-4057qib7 16171 13 transplant transplant NN cord-005453-4057qib7 16171 14 at at IN cord-005453-4057qib7 16171 15 our -PRON- PRP$ cord-005453-4057qib7 16171 16 Unit Unit NNP cord-005453-4057qib7 16171 17 between between IN cord-005453-4057qib7 16171 18 2011 2011 CD cord-005453-4057qib7 16171 19 and and CC cord-005453-4057qib7 16171 20 2018 2018 CD cord-005453-4057qib7 16171 21 and and CC cord-005453-4057qib7 16171 22 received receive VBN cord-005453-4057qib7 16171 23 BM BM NNP cord-005453-4057qib7 16171 24 ( ( -LRB- cord-005453-4057qib7 16171 25 n n NN cord-005453-4057qib7 16171 26 = = SYM cord-005453-4057qib7 16171 27 17 17 CD cord-005453-4057qib7 16171 28 ) ) -RRB- cord-005453-4057qib7 16171 29 or or CC cord-005453-4057qib7 16171 30 PBSC PBSC NNP cord-005453-4057qib7 16171 31 ( ( -LRB- cord-005453-4057qib7 16171 32 n n NN cord-005453-4057qib7 16171 33 = = SYM cord-005453-4057qib7 16171 34 18 18 CD cord-005453-4057qib7 16171 35 ) ) -RRB- cord-005453-4057qib7 16171 36 grafts graft NNS cord-005453-4057qib7 16171 37 after after IN cord-005453-4057qib7 16171 38 the the DT cord-005453-4057qib7 16171 39 same same JJ cord-005453-4057qib7 16171 40 TBF tbf NN cord-005453-4057qib7 16171 41 conditioning conditioning NN cord-005453-4057qib7 16171 42 regimen regimen NN cord-005453-4057qib7 16171 43 were be VBD cord-005453-4057qib7 16171 44 analysed analyse VBN cord-005453-4057qib7 16171 45 in in IN cord-005453-4057qib7 16171 46 order order NN cord-005453-4057qib7 16171 47 to to TO cord-005453-4057qib7 16171 48 assess assess VB cord-005453-4057qib7 16171 49 differences difference NNS cord-005453-4057qib7 16171 50 in in IN cord-005453-4057qib7 16171 51 transplant transplant NN cord-005453-4057qib7 16171 52 outcomes outcome NNS cord-005453-4057qib7 16171 53 . . . cord-005453-4057qib7 16172 1 Our -PRON- PRP$ cord-005453-4057qib7 16172 2 GVHD GVHD NNP cord-005453-4057qib7 16172 3 prophylaxis prophylaxis NN cord-005453-4057qib7 16172 4 consisted consist VBD cord-005453-4057qib7 16172 5 in in IN cord-005453-4057qib7 16172 6 cyclosporine cyclosporine NN cord-005453-4057qib7 16172 7 A a NN cord-005453-4057qib7 16172 8 ( ( -LRB- cord-005453-4057qib7 16172 9 CsA csa NN cord-005453-4057qib7 16172 10 ) ) -RRB- cord-005453-4057qib7 16172 11 from from IN cord-005453-4057qib7 16172 12 day day NN cord-005453-4057qib7 16172 13 -1 -1 . cord-005453-4057qib7 16173 1 to to IN cord-005453-4057qib7 16173 2 +180 +180 NNP cord-005453-4057qib7 16173 3 , , , cord-005453-4057qib7 16173 4 a a DT cord-005453-4057qib7 16173 5 methotrexate methotrexate NNP cord-005453-4057qib7 16173 6 " " `` cord-005453-4057qib7 16173 7 short short JJ cord-005453-4057qib7 16173 8 course course NN cord-005453-4057qib7 16173 9 " " '' cord-005453-4057qib7 16173 10 and and CC cord-005453-4057qib7 16173 11 mycophenolate mycophenolate NNP cord-005453-4057qib7 16173 12 mofetil mofetil NNP cord-005453-4057qib7 16173 13 ( ( -LRB- cord-005453-4057qib7 16173 14 MMF MMF NNP cord-005453-4057qib7 16173 15 ) ) -RRB- cord-005453-4057qib7 16173 16 from from IN cord-005453-4057qib7 16173 17 day day NN cord-005453-4057qib7 16173 18 +1 +1 XX cord-005453-4057qib7 16173 19 to to IN cord-005453-4057qib7 16173 20 +28.Results +28.Results NNP cord-005453-4057qib7 16173 21 : : : cord-005453-4057qib7 16174 1 No no DT cord-005453-4057qib7 16174 2 statistically statistically RB cord-005453-4057qib7 16174 3 - - HYPH cord-005453-4057qib7 16174 4 significant significant JJ cord-005453-4057qib7 16174 5 differences difference NNS cord-005453-4057qib7 16174 6 were be VBD cord-005453-4057qib7 16174 7 observed observe VBN cord-005453-4057qib7 16174 8 between between IN cord-005453-4057qib7 16174 9 patients patient NNS cord-005453-4057qib7 16174 10 who who WP cord-005453-4057qib7 16174 11 received receive VBD cord-005453-4057qib7 16174 12 BM BM NNP cord-005453-4057qib7 16174 13 grafts graft NNS cord-005453-4057qib7 16174 14 and and CC cord-005453-4057qib7 16174 15 those those DT cord-005453-4057qib7 16174 16 who who WP cord-005453-4057qib7 16174 17 received receive VBD cord-005453-4057qib7 16174 18 PBSC PBSC NNP cord-005453-4057qib7 16174 19 grafts graft NNS cord-005453-4057qib7 16174 20 . . . cord-005453-4057qib7 16175 1 At at IN cord-005453-4057qib7 16175 2 transplant transplant NN cord-005453-4057qib7 16175 3 fourteen fourteen CD cord-005453-4057qib7 16175 4 patients patient NNS cord-005453-4057qib7 16175 5 were be VBD cord-005453-4057qib7 16175 6 in in IN cord-005453-4057qib7 16175 7 first first JJ cord-005453-4057qib7 16175 8 complete complete JJ cord-005453-4057qib7 16175 9 remission remission NN cord-005453-4057qib7 16175 10 ( ( -LRB- cord-005453-4057qib7 16175 11 CR CR NNP cord-005453-4057qib7 16175 12 ) ) -RRB- cord-005453-4057qib7 16175 13 , , , cord-005453-4057qib7 16175 14 twelve twelve CD cord-005453-4057qib7 16175 15 in in IN cord-005453-4057qib7 16175 16 advanced advanced JJ cord-005453-4057qib7 16175 17 CR cr NN cord-005453-4057qib7 16175 18 and and CC cord-005453-4057qib7 16175 19 9 9 CD cord-005453-4057qib7 16175 20 had have VBD cord-005453-4057qib7 16175 21 active active JJ cord-005453-4057qib7 16175 22 disease disease NN cord-005453-4057qib7 16175 23 . . . cord-005453-4057qib7 16176 1 According accord VBG cord-005453-4057qib7 16176 2 to to IN cord-005453-4057qib7 16176 3 Sorror Sorror NNP cord-005453-4057qib7 16176 4 's 's POS cord-005453-4057qib7 16176 5 risk risk NN cord-005453-4057qib7 16176 6 , , , cord-005453-4057qib7 16176 7 nine nine CD cord-005453-4057qib7 16176 8 patients patient NNS cord-005453-4057qib7 16176 9 were be VBD cord-005453-4057qib7 16176 10 low low JJ cord-005453-4057qib7 16176 11 - - HYPH cord-005453-4057qib7 16176 12 risk risk NN cord-005453-4057qib7 16176 13 , , , cord-005453-4057qib7 16176 14 nine nine CD cord-005453-4057qib7 16176 15 intermediate intermediate JJ cord-005453-4057qib7 16176 16 - - HYPH cord-005453-4057qib7 16176 17 risk risk NN cord-005453-4057qib7 16176 18 and and CC cord-005453-4057qib7 16176 19 seventeen seventeen CD cord-005453-4057qib7 16176 20 high high JJ cord-005453-4057qib7 16176 21 - - HYPH cord-005453-4057qib7 16176 22 risk risk NN cord-005453-4057qib7 16176 23 . . . cord-005453-4057qib7 16177 1 Twenty twenty CD cord-005453-4057qib7 16177 2 - - HYPH cord-005453-4057qib7 16177 3 eight eight CD cord-005453-4057qib7 16177 4 CMV+ CMV+ NNP cord-005453-4057qib7 16177 5 patients patient NNS cord-005453-4057qib7 16177 6 received receive VBD cord-005453-4057qib7 16177 7 the the DT cord-005453-4057qib7 16177 8 graft graft NN cord-005453-4057qib7 16177 9 from from IN cord-005453-4057qib7 16177 10 twenty twenty CD cord-005453-4057qib7 16177 11 - - HYPH cord-005453-4057qib7 16177 12 three three CD cord-005453-4057qib7 16177 13 CMV+ CMV+ NNP cord-005453-4057qib7 16177 14 and and CC cord-005453-4057qib7 16177 15 five five CD cord-005453-4057qib7 16177 16 CMV CMV NNP cord-005453-4057qib7 16177 17 - - HYPH cord-005453-4057qib7 16177 18 donors donor NNS cord-005453-4057qib7 16177 19 , , , cord-005453-4057qib7 16177 20 seven seven CD cord-005453-4057qib7 16177 21 CMV CMV NNP cord-005453-4057qib7 16177 22 - - HYPH cord-005453-4057qib7 16177 23 patients patient NNS cord-005453-4057qib7 16177 24 received receive VBD cord-005453-4057qib7 16177 25 the the DT cord-005453-4057qib7 16177 26 graft graft NN cord-005453-4057qib7 16177 27 from from IN cord-005453-4057qib7 16177 28 five five CD cord-005453-4057qib7 16177 29 CMV+ CMV+ NNP cord-005453-4057qib7 16177 30 and and CC cord-005453-4057qib7 16177 31 two two CD cord-005453-4057qib7 16177 32 CMVdonors cmvdonor NNS cord-005453-4057qib7 16177 33 . . . cord-005453-4057qib7 16178 1 Mean mean JJ cord-005453-4057qib7 16178 2 age age NN cord-005453-4057qib7 16178 3 at at IN cord-005453-4057qib7 16178 4 transplant transplant NN cord-005453-4057qib7 16178 5 was be VBD cord-005453-4057qib7 16178 6 51 51 CD cord-005453-4057qib7 16178 7 years year NNS cord-005453-4057qib7 16179 1 ( ( -LRB- cord-005453-4057qib7 16179 2 range range NNP cord-005453-4057qib7 16179 3 23 23 CD cord-005453-4057qib7 16179 4 - - SYM cord-005453-4057qib7 16179 5 72 72 CD cord-005453-4057qib7 16179 6 ) ) -RRB- cord-005453-4057qib7 16179 7 , , , cord-005453-4057qib7 16179 8 mean mean JJ cord-005453-4057qib7 16179 9 donor donor NNP cord-005453-4057qib7 16179 10 's 's POS cord-005453-4057qib7 16179 11 age age NN cord-005453-4057qib7 16179 12 38 38 CD cord-005453-4057qib7 16179 13 years year NNS cord-005453-4057qib7 16179 14 ( ( -LRB- cord-005453-4057qib7 16179 15 range18 range18 NNP cord-005453-4057qib7 16179 16 - - SYM cord-005453-4057qib7 16179 17 39 39 CD cord-005453-4057qib7 16179 18 ) ) -RRB- cord-005453-4057qib7 16179 19 and and CC cord-005453-4057qib7 16179 20 mean mean VB cord-005453-4057qib7 16179 21 follow follow VB cord-005453-4057qib7 16179 22 - - HYPH cord-005453-4057qib7 16179 23 up up NN cord-005453-4057qib7 16179 24 16.9 16.9 CD cord-005453-4057qib7 16179 25 months month NNS cord-005453-4057qib7 16180 1 ( ( -LRB- cord-005453-4057qib7 16180 2 range range VBP cord-005453-4057qib7 16180 3 1.9 1.9 CD cord-005453-4057qib7 16180 4 - - HYPH cord-005453-4057qib7 16180 5 56.7 56.7 CD cord-005453-4057qib7 16180 6 ) ) -RRB- cord-005453-4057qib7 16180 7 . . . cord-005453-4057qib7 16181 1 Median median JJ cord-005453-4057qib7 16181 2 CD CD NNP cord-005453-4057qib7 16181 3 34 34 CD cord-005453-4057qib7 16181 4 + + CD cord-005453-4057qib7 16181 5 cell cell NN cord-005453-4057qib7 16181 6 dose dose NN cord-005453-4057qib7 16181 7 was be VBD cord-005453-4057qib7 16181 8 5.2x10 5.2x10 CD cord-005453-4057qib7 16181 9 6 6 CD cord-005453-4057qib7 16181 10 /kg /kg . cord-005453-4057qib7 16181 11 ( ( -LRB- cord-005453-4057qib7 16181 12 range1.4 range1.4 NNP cord-005453-4057qib7 16181 13 - - SYM cord-005453-4057qib7 16181 14 10.4 10.4 CD cord-005453-4057qib7 16181 15 ) ) -RRB- cord-005453-4057qib7 16181 16 , , , cord-005453-4057qib7 16181 17 3.6 3.6 CD cord-005453-4057qib7 16181 18 x10 x10 CD cord-005453-4057qib7 16181 19 6 6 CD cord-005453-4057qib7 16181 20 /kg /kg . cord-005453-4057qib7 16181 21 ( ( -LRB- cord-005453-4057qib7 16181 22 range range VB cord-005453-4057qib7 16181 23 1.4 1.4 CD cord-005453-4057qib7 16181 24 - - SYM cord-005453-4057qib7 16181 25 7.7 7.7 CD cord-005453-4057qib7 16181 26 ) ) -RRB- cord-005453-4057qib7 16181 27 in in IN cord-005453-4057qib7 16181 28 BM BM NNP cord-005453-4057qib7 16181 29 recipients recipient NNS cord-005453-4057qib7 16181 30 and and CC cord-005453-4057qib7 16181 31 14.0 14.0 CD cord-005453-4057qib7 16181 32 x10 x10 CD cord-005453-4057qib7 16181 33 6 6 CD cord-005453-4057qib7 16182 1 /kg /kg NFP cord-005453-4057qib7 16182 2 ( ( -LRB- cord-005453-4057qib7 16182 3 range range VB cord-005453-4057qib7 16182 4 4.2 4.2 CD cord-005453-4057qib7 16182 5 - - HYPH cord-005453-4057qib7 16182 6 10.4 10.4 CD cord-005453-4057qib7 16182 7 ) ) -RRB- cord-005453-4057qib7 16182 8 in in IN cord-005453-4057qib7 16182 9 PBSC PBSC NNP cord-005453-4057qib7 16182 10 recipients recipient NNS cord-005453-4057qib7 16182 11 . . . cord-005453-4057qib7 16183 1 Median median JJ cord-005453-4057qib7 16183 2 time time NN cord-005453-4057qib7 16183 3 to to IN cord-005453-4057qib7 16183 4 neutrophil neutrophil NN cord-005453-4057qib7 16183 5 recovery recovery NN cord-005453-4057qib7 16183 6 ( ( -LRB- cord-005453-4057qib7 16183 7 > > VBZ cord-005453-4057qib7 16183 8 500 500 CD cord-005453-4057qib7 16183 9 / / SYM cord-005453-4057qib7 16183 10 μl μl NN cord-005453-4057qib7 16183 11 ) ) -RRB- cord-005453-4057qib7 16183 12 was be VBD cord-005453-4057qib7 16183 13 22 22 CD cord-005453-4057qib7 16183 14 days day NNS cord-005453-4057qib7 16184 1 ( ( -LRB- cord-005453-4057qib7 16184 2 range range NNP cord-005453-4057qib7 16184 3 16 16 CD cord-005453-4057qib7 16184 4 - - SYM cord-005453-4057qib7 16184 5 39 39 CD cord-005453-4057qib7 16184 6 ) ) -RRB- cord-005453-4057qib7 16185 1 posttransplant posttransplant NNP cord-005453-4057qib7 16185 2 , , , cord-005453-4057qib7 16185 3 23 23 CD cord-005453-4057qib7 16185 4 days day NNS cord-005453-4057qib7 16185 5 ( ( -LRB- cord-005453-4057qib7 16185 6 range range VBP cord-005453-4057qib7 16185 7 18 18 CD cord-005453-4057qib7 16185 8 - - SYM cord-005453-4057qib7 16185 9 27 27 CD cord-005453-4057qib7 16185 10 ) ) -RRB- cord-005453-4057qib7 16185 11 for for IN cord-005453-4057qib7 16185 12 BM BM NNP cord-005453-4057qib7 16185 13 recipients recipient NNS cord-005453-4057qib7 16185 14 and and CC cord-005453-4057qib7 16185 15 20 20 CD cord-005453-4057qib7 16185 16 ( ( -LRB- cord-005453-4057qib7 16185 17 range range NNP cord-005453-4057qib7 16185 18 16 16 CD cord-005453-4057qib7 16185 19 - - SYM cord-005453-4057qib7 16185 20 39 39 CD cord-005453-4057qib7 16185 21 ) ) -RRB- cord-005453-4057qib7 16185 22 for for IN cord-005453-4057qib7 16185 23 PBSC PBSC NNP cord-005453-4057qib7 16185 24 recipients recipient NNS cord-005453-4057qib7 16185 25 . . . cord-005453-4057qib7 16186 1 Platelet platelet NN cord-005453-4057qib7 16186 2 recovery recovery NN cord-005453-4057qib7 16186 3 ( ( -LRB- cord-005453-4057qib7 16186 4 > > XX cord-005453-4057qib7 16187 1 20.000 20.000 CD cord-005453-4057qib7 16187 2 / / SYM cord-005453-4057qib7 16187 3 μl μl NN cord-005453-4057qib7 16187 4 ) ) -RRB- cord-005453-4057qib7 16187 5 occurred occur VBD cord-005453-4057qib7 16187 6 in in IN cord-005453-4057qib7 16187 7 all all DT cord-005453-4057qib7 16187 8 patients patient NNS cord-005453-4057qib7 16187 9 except except IN cord-005453-4057qib7 16187 10 one one CD cord-005453-4057qib7 16187 11 at at IN cord-005453-4057qib7 16187 12 a a DT cord-005453-4057qib7 16187 13 median median NN cord-005453-4057qib7 16187 14 of of IN cord-005453-4057qib7 16187 15 17 17 CD cord-005453-4057qib7 16187 16 days day NNS cord-005453-4057qib7 16187 17 ( ( -LRB- cord-005453-4057qib7 16187 18 range range VBP cord-005453-4057qib7 16187 19 10 10 CD cord-005453-4057qib7 16187 20 - - SYM cord-005453-4057qib7 16187 21 151 151 CD cord-005453-4057qib7 16187 22 ) ) -RRB- cord-005453-4057qib7 16188 1 post post JJ cord-005453-4057qib7 16188 2 - - JJ cord-005453-4057qib7 16188 3 transplant transplant NN cord-005453-4057qib7 16188 4 , , , cord-005453-4057qib7 16188 5 at at IN cord-005453-4057qib7 16188 6 a a DT cord-005453-4057qib7 16188 7 median median NN cord-005453-4057qib7 16188 8 of of IN cord-005453-4057qib7 16188 9 20 20 CD cord-005453-4057qib7 16188 10 days day NNS cord-005453-4057qib7 16188 11 ( ( -LRB- cord-005453-4057qib7 16188 12 11 11 CD cord-005453-4057qib7 16188 13 - - SYM cord-005453-4057qib7 16188 14 151 151 CD cord-005453-4057qib7 16188 15 ) ) -RRB- cord-005453-4057qib7 16188 16 post post JJ cord-005453-4057qib7 16188 17 - - NN cord-005453-4057qib7 16188 18 transplant transplant NN cord-005453-4057qib7 16188 19 for for IN cord-005453-4057qib7 16188 20 BM BM NNP cord-005453-4057qib7 16188 21 recipients recipient NNS cord-005453-4057qib7 16188 22 and and CC cord-005453-4057qib7 16188 23 at at IN cord-005453-4057qib7 16188 24 a a DT cord-005453-4057qib7 16188 25 median median NN cord-005453-4057qib7 16188 26 of of IN cord-005453-4057qib7 16188 27 14 14 CD cord-005453-4057qib7 16188 28 days day NNS cord-005453-4057qib7 16188 29 ( ( -LRB- cord-005453-4057qib7 16188 30 range range NN cord-005453-4057qib7 16188 31 ( ( -LRB- cord-005453-4057qib7 16188 32 10 10 CD cord-005453-4057qib7 16188 33 - - SYM cord-005453-4057qib7 16188 34 26 26 CD cord-005453-4057qib7 16188 35 ) ) -RRB- cord-005453-4057qib7 16188 36 for for IN cord-005453-4057qib7 16188 37 PBSC PBSC NNP cord-005453-4057qib7 16188 38 recipients recipient NNS cord-005453-4057qib7 16188 39 . . . cord-005453-4057qib7 16189 1 Seven seven CD cord-005453-4057qib7 16189 2 patients patient NNS cord-005453-4057qib7 16189 3 never never RB cord-005453-4057qib7 16189 4 reached reach VBD cord-005453-4057qib7 16189 5 platelets platelet NNS cord-005453-4057qib7 16189 6 > > XX cord-005453-4057qib7 16190 1 50.000 50.000 CD cord-005453-4057qib7 16190 2 / / SYM cord-005453-4057qib7 16190 3 μl μl NN cord-005453-4057qib7 16190 4 . . . cord-005453-4057qib7 16191 1 Three three CD cord-005453-4057qib7 16191 2 patients patient NNS cord-005453-4057qib7 16191 3 developed develop VBD cord-005453-4057qib7 16191 4 a a DT cord-005453-4057qib7 16191 5 poor poor JJ cord-005453-4057qib7 16191 6 graft graft NN cord-005453-4057qib7 16191 7 function function NN cord-005453-4057qib7 16191 8 . . . cord-005453-4057qib7 16192 1 Acute acute JJ cord-005453-4057qib7 16192 2 and and CC cord-005453-4057qib7 16192 3 chronic chronic JJ cord-005453-4057qib7 16192 4 GVHD GVHD NNP cord-005453-4057qib7 16192 5 incidence incidence NN cord-005453-4057qib7 16192 6 was be VBD cord-005453-4057qib7 16192 7 28.5 28.5 CD cord-005453-4057qib7 16192 8 % % NN cord-005453-4057qib7 16192 9 and and CC cord-005453-4057qib7 16192 10 22.8 22.8 CD cord-005453-4057qib7 16192 11 % % NN cord-005453-4057qib7 16192 12 and and CC cord-005453-4057qib7 16192 13 the the DT cord-005453-4057qib7 16192 14 risks risk NNS cord-005453-4057qib7 16192 15 of of IN cord-005453-4057qib7 16192 16 acute acute JJ cord-005453-4057qib7 16192 17 ( ( -LRB- cord-005453-4057qib7 16192 18 hazard hazard NN cord-005453-4057qib7 16192 19 ratio ratio NN cord-005453-4057qib7 16192 20 [ [ -LRB- cord-005453-4057qib7 16192 21 HR HR NNP cord-005453-4057qib7 16192 22 ] ] -RRB- cord-005453-4057qib7 16192 23 , , , cord-005453-4057qib7 16192 24 1.04 1.04 CD cord-005453-4057qib7 16192 25 ; ; : cord-005453-4057qib7 16192 26 P p NN cord-005453-4057qib7 16192 27 = = SYM cord-005453-4057qib7 16192 28 .955 .955 CD cord-005453-4057qib7 16192 29 ) ) -RRB- cord-005453-4057qib7 16192 30 and and CC cord-005453-4057qib7 16192 31 chronic chronic JJ cord-005453-4057qib7 16192 32 ( ( -LRB- cord-005453-4057qib7 16192 33 HR HR NNP cord-005453-4057qib7 16192 34 , , , cord-005453-4057qib7 16192 35 0.85 0.85 CD cord-005453-4057qib7 16192 36 ; ; : cord-005453-4057qib7 16192 37 P p NN cord-005453-4057qib7 16192 38 = = SYM cord-005453-4057qib7 16192 39 .816 .816 NFP cord-005453-4057qib7 16192 40 ) ) -RRB- cord-005453-4057qib7 16192 41 graft graft NN cord-005453-4057qib7 16192 42 - - HYPH cord-005453-4057qib7 16192 43 versus versus IN cord-005453-4057qib7 16192 44 - - HYPH cord-005453-4057qib7 16192 45 host host NN cord-005453-4057qib7 16192 46 disease disease NN cord-005453-4057qib7 16192 47 were be VBD cord-005453-4057qib7 16192 48 similar similar JJ cord-005453-4057qib7 16192 49 in in IN cord-005453-4057qib7 16192 50 the the DT cord-005453-4057qib7 16192 51 two two CD cord-005453-4057qib7 16192 52 patient patient JJ cord-005453-4057qib7 16192 53 groups group NNS cord-005453-4057qib7 16192 54 . . . cord-005453-4057qib7 16193 1 In in IN cord-005453-4057qib7 16193 2 addition addition NN cord-005453-4057qib7 16193 3 , , , cord-005453-4057qib7 16193 4 there there EX cord-005453-4057qib7 16193 5 were be VBD cord-005453-4057qib7 16193 6 no no DT cord-005453-4057qib7 16193 7 differences difference NNS cord-005453-4057qib7 16193 8 in in IN cord-005453-4057qib7 16193 9 relapse relapse NN cord-005453-4057qib7 16193 10 risks risk VBZ cord-005453-4057qib7 16193 11 post post JJ cord-005453-4057qib7 16193 12 - - NN cord-005453-4057qib7 16193 13 transplant transplant NN cord-005453-4057qib7 16193 14 ( ( -LRB- cord-005453-4057qib7 16193 15 HR HR NNP cord-005453-4057qib7 16193 16 , , , cord-005453-4057qib7 16193 17 0.90 0.90 CD cord-005453-4057qib7 16193 18 ; ; : cord-005453-4057qib7 16193 19 P p NN cord-005453-4057qib7 16193 20 = = SYM cord-005453-4057qib7 16193 21 .898 .898 CD cord-005453-4057qib7 16193 22 ) ) -RRB- cord-005453-4057qib7 16193 23 ; ; : cord-005453-4057qib7 16193 24 relapse relapse NN cord-005453-4057qib7 16193 25 - - HYPH cord-005453-4057qib7 16193 26 free free JJ cord-005453-4057qib7 16193 27 survival survival NN cord-005453-4057qib7 16193 28 was be VBD cord-005453-4057qib7 16193 29 better well JJR cord-005453-4057qib7 16193 30 with with IN cord-005453-4057qib7 16193 31 PBSC PBSC NNP cord-005453-4057qib7 16193 32 grafts graft NNS cord-005453-4057qib7 16193 33 but but CC cord-005453-4057qib7 16193 34 this this DT cord-005453-4057qib7 16193 35 difference difference NN cord-005453-4057qib7 16193 36 did do VBD cord-005453-4057qib7 16193 37 not not RB cord-005453-4057qib7 16193 38 reach reach VB cord-005453-4057qib7 16193 39 any any DT cord-005453-4057qib7 16193 40 statistical statistical JJ cord-005453-4057qib7 16193 41 significance significance NN cord-005453-4057qib7 16193 42 . . . cord-005453-4057qib7 16194 1 Finally finally RB cord-005453-4057qib7 16194 2 , , , cord-005453-4057qib7 16194 3 no no DT cord-005453-4057qib7 16194 4 significant significant JJ cord-005453-4057qib7 16194 5 differences difference NNS cord-005453-4057qib7 16194 6 were be VBD cord-005453-4057qib7 16194 7 noted note VBN cord-005453-4057qib7 16194 8 in in IN cord-005453-4057qib7 16194 9 overall overall JJ cord-005453-4057qib7 16194 10 mortality mortality NN cord-005453-4057qib7 16194 11 by by IN cord-005453-4057qib7 16194 12 graft graft NN cord-005453-4057qib7 16194 13 type type NN cord-005453-4057qib7 16194 14 ( ( -LRB- cord-005453-4057qib7 16194 15 HR hr NN cord-005453-4057qib7 16194 16 , , , cord-005453-4057qib7 16194 17 0.62 0.62 CD cord-005453-4057qib7 16194 18 ; ; : cord-005453-4057qib7 16194 19 P p NN cord-005453-4057qib7 16194 20 = = SYM cord-005453-4057qib7 16194 21 .441).Conclusions .441).Conclusions . cord-005453-4057qib7 16195 1 : : : cord-005453-4057qib7 16196 1 Despite despite IN cord-005453-4057qib7 16196 2 in in IN cord-005453-4057qib7 16196 3 haplo haplo NNP cord-005453-4057qib7 16196 4 - - HYPH cord-005453-4057qib7 16196 5 HSCT HSCT NNP cord-005453-4057qib7 16196 6 the the DT cord-005453-4057qib7 16196 7 incidence incidence NN cord-005453-4057qib7 16196 8 of of IN cord-005453-4057qib7 16196 9 acute acute JJ cord-005453-4057qib7 16196 10 and and CC cord-005453-4057qib7 16196 11 chronic chronic JJ cord-005453-4057qib7 16196 12 GVHD GVHD NNP cord-005453-4057qib7 16196 13 is be VBZ cord-005453-4057qib7 16196 14 reported report VBN cord-005453-4057qib7 16196 15 to to TO cord-005453-4057qib7 16196 16 be be VB cord-005453-4057qib7 16196 17 higher high JJR cord-005453-4057qib7 16196 18 with with IN cord-005453-4057qib7 16196 19 PBSC PBSC NNP cord-005453-4057qib7 16196 20 than than IN cord-005453-4057qib7 16196 21 with with IN cord-005453-4057qib7 16196 22 BM BM NNP cord-005453-4057qib7 16197 1 our -PRON- PRP$ cord-005453-4057qib7 16197 2 small small JJ cord-005453-4057qib7 16197 3 patient patient NN cord-005453-4057qib7 16197 4 series series NN cord-005453-4057qib7 16197 5 does do VBZ cord-005453-4057qib7 16197 6 not not RB cord-005453-4057qib7 16197 7 confirm confirm VB cord-005453-4057qib7 16197 8 this this DT cord-005453-4057qib7 16197 9 assumption assumption NN cord-005453-4057qib7 16197 10 that that WDT cord-005453-4057qib7 16197 11 should should MD cord-005453-4057qib7 16197 12 be be VB cord-005453-4057qib7 16197 13 clarified clarify VBN cord-005453-4057qib7 16197 14 by by IN cord-005453-4057qib7 16197 15 additional additional JJ cord-005453-4057qib7 16197 16 studies study NNS cord-005453-4057qib7 16197 17 . . . cord-005453-4057qib7 16198 1 Instead instead RB cord-005453-4057qib7 16198 2 , , , cord-005453-4057qib7 16198 3 our -PRON- PRP$ cord-005453-4057qib7 16198 4 data datum NNS cord-005453-4057qib7 16198 5 suggest suggest VBP cord-005453-4057qib7 16198 6 that that IN cord-005453-4057qib7 16198 7 PBSC PBSC NNP cord-005453-4057qib7 16198 8 Background Background NNP cord-005453-4057qib7 16198 9 : : : cord-005453-4057qib7 16199 1 Since since IN cord-005453-4057qib7 16199 2 1988 1988 CD cord-005453-4057qib7 16199 3 , , , cord-005453-4057qib7 16199 4 cord cord NN cord-005453-4057qib7 16199 5 blood blood NN cord-005453-4057qib7 16199 6 ( ( -LRB- cord-005453-4057qib7 16199 7 CBU CBU NNP cord-005453-4057qib7 16199 8 ) ) -RRB- cord-005453-4057qib7 16199 9 has have VBZ cord-005453-4057qib7 16199 10 become become VBN cord-005453-4057qib7 16199 11 an an DT cord-005453-4057qib7 16199 12 alternative alternative JJ cord-005453-4057qib7 16199 13 source source NN cord-005453-4057qib7 16199 14 of of IN cord-005453-4057qib7 16199 15 stem stem NN cord-005453-4057qib7 16199 16 cells cell NNS cord-005453-4057qib7 16199 17 for for IN cord-005453-4057qib7 16199 18 transplantation transplantation NN cord-005453-4057qib7 16199 19 , , , cord-005453-4057qib7 16199 20 with with IN cord-005453-4057qib7 16199 21 approximately approximately RB cord-005453-4057qib7 16199 22 35,000 35,000 CD cord-005453-4057qib7 16199 23 procedures procedure NNS cord-005453-4057qib7 16199 24 currently currently RB cord-005453-4057qib7 16199 25 performed perform VBN cord-005453-4057qib7 16199 26 . . . cord-005453-4057qib7 16200 1 With with IN cord-005453-4057qib7 16200 2 a a DT cord-005453-4057qib7 16200 3 2-year 2-year CD cord-005453-4057qib7 16200 4 GS GS NNP cord-005453-4057qib7 16200 5 of of IN cord-005453-4057qib7 16200 6 50%.Objective 50%.objective CD cord-005453-4057qib7 16200 7 : : : cord-005453-4057qib7 16200 8 Analyze analyze VB cord-005453-4057qib7 16200 9 the the DT cord-005453-4057qib7 16200 10 outcomes outcome NNS cord-005453-4057qib7 16200 11 from from IN cord-005453-4057qib7 16200 12 all all PDT cord-005453-4057qib7 16200 13 the the DT cord-005453-4057qib7 16200 14 patients patient NNS cord-005453-4057qib7 16200 15 transplanted transplant VBN cord-005453-4057qib7 16200 16 with with IN cord-005453-4057qib7 16200 17 CBU CBU NNP cord-005453-4057qib7 16200 18 in in IN cord-005453-4057qib7 16200 19 our -PRON- PRP$ cord-005453-4057qib7 16200 20 hospital hospital NN cord-005453-4057qib7 16200 21 unit unit NN cord-005453-4057qib7 16200 22 . . . cord-005453-4057qib7 16201 1 Methods method NNS cord-005453-4057qib7 16201 2 : : : cord-005453-4057qib7 16201 3 Retrospective retrospective JJ cord-005453-4057qib7 16201 4 , , , cord-005453-4057qib7 16201 5 longitudinal longitudinal JJ cord-005453-4057qib7 16201 6 study study NN cord-005453-4057qib7 16201 7 . . . cord-005453-4057qib7 16202 1 All all DT cord-005453-4057qib7 16202 2 patients patient NNS cord-005453-4057qib7 16202 3 transplanted transplant VBN cord-005453-4057qib7 16202 4 with with IN cord-005453-4057qib7 16202 5 CBU CBU NNP cord-005453-4057qib7 16202 6 in in IN cord-005453-4057qib7 16202 7 our -PRON- PRP$ cord-005453-4057qib7 16202 8 hospital hospital NN cord-005453-4057qib7 16202 9 between between IN cord-005453-4057qib7 16202 10 2007 2007 CD cord-005453-4057qib7 16202 11 and and CC cord-005453-4057qib7 16202 12 2017 2017 CD cord-005453-4057qib7 16202 13 were be VBD cord-005453-4057qib7 16202 14 included include VBN cord-005453-4057qib7 16202 15 . . . cord-005453-4057qib7 16203 1 We -PRON- PRP cord-005453-4057qib7 16203 2 analyzed analyze VBD cord-005453-4057qib7 16203 3 40 40 CD cord-005453-4057qib7 16203 4 patients patient NNS cord-005453-4057qib7 16203 5 with with IN cord-005453-4057qib7 16203 6 ages age NNS cord-005453-4057qib7 16203 7 from from IN cord-005453-4057qib7 16203 8 7 7 CD cord-005453-4057qib7 16203 9 months month NNS cord-005453-4057qib7 16203 10 to to IN cord-005453-4057qib7 16203 11 14 14 CD cord-005453-4057qib7 16203 12 years year NNS cord-005453-4057qib7 16203 13 . . . cord-005453-4057qib7 16204 1 Results result NNS cord-005453-4057qib7 16204 2 : : : cord-005453-4057qib7 16205 1 Two two CD cord-005453-4057qib7 16205 2 of of IN cord-005453-4057qib7 16205 3 them -PRON- PRP cord-005453-4057qib7 16205 4 received receive VBD cord-005453-4057qib7 16205 5 doubled double VBN cord-005453-4057qib7 16205 6 cord cord NN cord-005453-4057qib7 16205 7 transplantation transplantation NN cord-005453-4057qib7 16206 1 the the DT cord-005453-4057qib7 16206 2 ratio ratio NN cord-005453-4057qib7 16206 3 male male NN cord-005453-4057qib7 16206 4 : : : cord-005453-4057qib7 16206 5 female female JJ cord-005453-4057qib7 16206 6 was be VBD cord-005453-4057qib7 16206 7 1.3 1.3 CD cord-005453-4057qib7 16206 8 : : SYM cord-005453-4057qib7 16206 9 1 1 CD cord-005453-4057qib7 16206 10 . . . cord-005453-4057qib7 16207 1 The the DT cord-005453-4057qib7 16207 2 transplanted transplanted JJ cord-005453-4057qib7 16207 3 pathologies pathology NNS cord-005453-4057qib7 16207 4 were be VBD cord-005453-4057qib7 16207 5 : : : cord-005453-4057qib7 16207 6 Bone bone NN cord-005453-4057qib7 16207 7 marrow marrow NN cord-005453-4057qib7 16207 8 failure failure NN cord-005453-4057qib7 16207 9 35 35 CD cord-005453-4057qib7 16207 10 % % NN cord-005453-4057qib7 16207 11 , , , cord-005453-4057qib7 16207 12 immunodeficiency immunodeficiency NN cord-005453-4057qib7 16207 13 25 25 CD cord-005453-4057qib7 16207 14 % % NN cord-005453-4057qib7 16207 15 , , , cord-005453-4057qib7 16207 16 AML AML NNP cord-005453-4057qib7 16207 17 20 20 CD cord-005453-4057qib7 16207 18 % % NN cord-005453-4057qib7 16207 19 , , , cord-005453-4057qib7 16207 20 ALL all DT cord-005453-4057qib7 16207 21 17.5 17.5 CD cord-005453-4057qib7 16207 22 % % NN cord-005453-4057qib7 16207 23 , , , cord-005453-4057qib7 16207 24 Osteopetrosis Osteopetrosis NNP cord-005453-4057qib7 16207 25 2.5 2.5 CD cord-005453-4057qib7 16207 26 % % NN cord-005453-4057qib7 16207 27 . . . cord-005453-4057qib7 16208 1 RIC RIC NNP cord-005453-4057qib7 16208 2 regimens regimen NNS cord-005453-4057qib7 16208 3 were be VBD cord-005453-4057qib7 16208 4 used use VBN cord-005453-4057qib7 16208 5 in in IN cord-005453-4057qib7 16208 6 patients patient NNS cord-005453-4057qib7 16208 7 with with IN cord-005453-4057qib7 16208 8 bone bone NN cord-005453-4057qib7 16208 9 marrow marrow NN cord-005453-4057qib7 16208 10 failure failure NN cord-005453-4057qib7 16208 11 and and CC cord-005453-4057qib7 16208 12 immunodeficiency immunodeficiency NN cord-005453-4057qib7 16208 13 and and CC cord-005453-4057qib7 16208 14 myeloablative myeloablative JJ cord-005453-4057qib7 16208 15 conditioning conditioning NN cord-005453-4057qib7 16208 16 regimens regimen NNS cord-005453-4057qib7 16208 17 were be VBD cord-005453-4057qib7 16208 18 used use VBN cord-005453-4057qib7 16208 19 in in IN cord-005453-4057qib7 16208 20 patients patient NNS cord-005453-4057qib7 16208 21 with with IN cord-005453-4057qib7 16208 22 malignant malignant JJ cord-005453-4057qib7 16208 23 hematology hematology NN cord-005453-4057qib7 16208 24 diseases disease NNS cord-005453-4057qib7 16208 25 . . . cord-005453-4057qib7 16209 1 Antithymocyte antithymocyte JJ cord-005453-4057qib7 16209 2 rabbit rabbit NN cord-005453-4057qib7 16209 3 globulin globulin NN cord-005453-4057qib7 16209 4 ( ( -LRB- cord-005453-4057qib7 16209 5 ATG ATG NNP cord-005453-4057qib7 16209 6 ) ) -RRB- cord-005453-4057qib7 16210 1 based base VBN cord-005453-4057qib7 16210 2 serotherapy serotherapy NNP cord-005453-4057qib7 16210 3 was be VBD cord-005453-4057qib7 16210 4 used use VBN cord-005453-4057qib7 16210 5 . . . cord-005453-4057qib7 16211 1 One one CD cord-005453-4057qib7 16211 2 case case NN cord-005453-4057qib7 16211 3 received receive VBD cord-005453-4057qib7 16211 4 CBU CBU NNP cord-005453-4057qib7 16211 5 from from IN cord-005453-4057qib7 16211 6 a a DT cord-005453-4057qib7 16211 7 related related JJ cord-005453-4057qib7 16211 8 donor donor NN cord-005453-4057qib7 16211 9 ( ( -LRB- cord-005453-4057qib7 16211 10 sister sister NN cord-005453-4057qib7 16211 11 ) ) -RRB- cord-005453-4057qib7 16211 12 , , , cord-005453-4057qib7 16211 13 the the DT cord-005453-4057qib7 16211 14 rest rest NN cord-005453-4057qib7 16211 15 received receive VBD cord-005453-4057qib7 16211 16 unrelated unrelated JJ cord-005453-4057qib7 16211 17 CBU CBU NNP cord-005453-4057qib7 16211 18 obtained obtain VBN cord-005453-4057qib7 16211 19 from from IN cord-005453-4057qib7 16211 20 Centro Centro NNP cord-005453-4057qib7 16211 21 Nacional Nacional NNP cord-005453-4057qib7 16211 22 de de NNP cord-005453-4057qib7 16211 23 la la NNP cord-005453-4057qib7 16211 24 Trasfusión Trasfusión NNP cord-005453-4057qib7 16211 25 Sanguínea Sanguínea NNP cord-005453-4057qib7 16211 26 . . . cord-005453-4057qib7 16212 1 The the DT cord-005453-4057qib7 16212 2 infusion infusion NN cord-005453-4057qib7 16212 3 of of IN cord-005453-4057qib7 16212 4 CD34 CD34 NNP cord-005453-4057qib7 16212 5 + + CC cord-005453-4057qib7 16212 6 was be VBD cord-005453-4057qib7 16212 7 in in IN cord-005453-4057qib7 16212 8 a a DT cord-005453-4057qib7 16212 9 range range NN cord-005453-4057qib7 16212 10 of of IN cord-005453-4057qib7 16212 11 0.11 0.11 CD cord-005453-4057qib7 16212 12 to to IN cord-005453-4057qib7 16212 13 of of IN cord-005453-4057qib7 16212 14 2.7 2.7 CD cord-005453-4057qib7 16212 15 X10 X10 NNP cord-005453-4057qib7 16212 16 6 6 CD cord-005453-4057qib7 16212 17 /kg /kg NFP cord-005453-4057qib7 16212 18 with with IN cord-005453-4057qib7 16212 19 and and CC cord-005453-4057qib7 16212 20 average average NN cord-005453-4057qib7 16212 21 of of IN cord-005453-4057qib7 16212 22 0.43 0.43 CD cord-005453-4057qib7 16212 23 X x SYM cord-005453-4057qib7 16212 24 10 10 CD cord-005453-4057qib7 16212 25 6 6 CD cord-005453-4057qib7 16212 26 / / SYM cord-005453-4057qib7 16212 27 kg kg NNS cord-005453-4057qib7 16212 28 . . . cord-005453-4057qib7 16213 1 Compatibility compatibility NN cord-005453-4057qib7 16213 2 was be VBD cord-005453-4057qib7 16213 3 4/6 4/6 CD cord-005453-4057qib7 16213 4 in in IN cord-005453-4057qib7 16213 5 70 70 CD cord-005453-4057qib7 16213 6 % % NN cord-005453-4057qib7 16213 7 , , , cord-005453-4057qib7 16213 8 5/6 5/6 CD cord-005453-4057qib7 16213 9 in in IN cord-005453-4057qib7 16213 10 20 20 CD cord-005453-4057qib7 16213 11 % % NN cord-005453-4057qib7 16213 12 and and CC cord-005453-4057qib7 16213 13 6/6 6/6 CD cord-005453-4057qib7 16213 14 in in IN cord-005453-4057qib7 16213 15 10 10 CD cord-005453-4057qib7 16213 16 % % NN cord-005453-4057qib7 16213 17 . . . cord-005453-4057qib7 16214 1 Post post JJ cord-005453-4057qib7 16214 2 - - JJ cord-005453-4057qib7 16214 3 thawing thaw VBG cord-005453-4057qib7 16214 4 cellularity cellularity NN cord-005453-4057qib7 16214 5 was be VBD cord-005453-4057qib7 16214 6 not not RB cord-005453-4057qib7 16214 7 measured measure VBN cord-005453-4057qib7 16214 8 . . . cord-005453-4057qib7 16215 1 The the DT cord-005453-4057qib7 16215 2 HLA HLA NNP cord-005453-4057qib7 16215 3 - - HYPH cord-005453-4057qib7 16215 4 C C NNP cord-005453-4057qib7 16215 5 was be VBD cord-005453-4057qib7 16215 6 not not RB cord-005453-4057qib7 16215 7 analyzed analyze VBN cord-005453-4057qib7 16215 8 . . . cord-005453-4057qib7 16216 1 Forty forty CD cord-005453-4057qib7 16216 2 two two CD cord-005453-4057qib7 16216 3 point point NN cord-005453-4057qib7 16216 4 five five CD cord-005453-4057qib7 16216 5 percent percent NN cord-005453-4057qib7 16216 6 of of IN cord-005453-4057qib7 16216 7 the the DT cord-005453-4057qib7 16216 8 patients patient NNS cord-005453-4057qib7 16216 9 had have VBD cord-005453-4057qib7 16216 10 a a DT cord-005453-4057qib7 16216 11 successful successful JJ cord-005453-4057qib7 16216 12 engraftment engraftment NN cord-005453-4057qib7 16216 13 ; ; : cord-005453-4057qib7 16216 14 the the DT cord-005453-4057qib7 16216 15 average average JJ cord-005453-4057qib7 16216 16 time time NN cord-005453-4057qib7 16216 17 of of IN cord-005453-4057qib7 16216 18 engraftment engraftment NN cord-005453-4057qib7 16216 19 was be VBD cord-005453-4057qib7 16216 20 30 30 CD cord-005453-4057qib7 16216 21 days day NNS cord-005453-4057qib7 16216 22 . . . cord-005453-4057qib7 16217 1 Primary primary JJ cord-005453-4057qib7 16217 2 graft graft NN cord-005453-4057qib7 16217 3 failure failure NN cord-005453-4057qib7 16217 4 was be VBD cord-005453-4057qib7 16217 5 detected detect VBN cord-005453-4057qib7 16217 6 in in IN cord-005453-4057qib7 16217 7 57.5 57.5 CD cord-005453-4057qib7 16217 8 % % NN cord-005453-4057qib7 16217 9 and and CC cord-005453-4057qib7 16217 10 secondary secondary JJ cord-005453-4057qib7 16217 11 graft graft NN cord-005453-4057qib7 16217 12 failure failure NN cord-005453-4057qib7 16217 13 in in IN cord-005453-4057qib7 16217 14 10 10 CD cord-005453-4057qib7 16217 15 % % NN cord-005453-4057qib7 16217 16 , , , cord-005453-4057qib7 16217 17 for for IN cord-005453-4057qib7 16217 18 a a DT cord-005453-4057qib7 16217 19 total total JJ cord-005453-4057qib7 16217 20 success success NN cord-005453-4057qib7 16217 21 of of IN cord-005453-4057qib7 16217 22 32.5 32.5 CD cord-005453-4057qib7 16217 23 % % NN cord-005453-4057qib7 16217 24 . . . cord-005453-4057qib7 16218 1 GVHD GVHD NNP cord-005453-4057qib7 16218 2 was be VBD cord-005453-4057qib7 16218 3 detected detect VBN cord-005453-4057qib7 16218 4 in in IN cord-005453-4057qib7 16218 5 20 20 CD cord-005453-4057qib7 16218 6 % % NN cord-005453-4057qib7 16218 7 of of IN cord-005453-4057qib7 16218 8 patients patient NNS cord-005453-4057qib7 16218 9 , , , cord-005453-4057qib7 16218 10 of of IN cord-005453-4057qib7 16218 11 which which WDT cord-005453-4057qib7 16218 12 90 90 CD cord-005453-4057qib7 16218 13 % % NN cord-005453-4057qib7 16218 14 was be VBD cord-005453-4057qib7 16218 15 grade grade NN cord-005453-4057qib7 16218 16 I I NNP cord-005453-4057qib7 16218 17 - - HYPH cord-005453-4057qib7 16218 18 II II NNP cord-005453-4057qib7 16218 19 and and CC cord-005453-4057qib7 16218 20 10 10 CD cord-005453-4057qib7 16218 21 % % NN cord-005453-4057qib7 16218 22 grade grade NN cord-005453-4057qib7 16218 23 III III NNP cord-005453-4057qib7 16218 24 - - HYPH cord-005453-4057qib7 16218 25 IV IV NNP cord-005453-4057qib7 16218 26 . . . cord-005453-4057qib7 16219 1 The the DT cord-005453-4057qib7 16219 2 overall overall JJ cord-005453-4057qib7 16219 3 mortality mortality NN cord-005453-4057qib7 16219 4 was be VBD cord-005453-4057qib7 16219 5 52.5 52.5 CD cord-005453-4057qib7 16219 6 % % NN cord-005453-4057qib7 16219 7 . . . cord-005453-4057qib7 16220 1 Causes cause NNS cord-005453-4057qib7 16220 2 of of IN cord-005453-4057qib7 16220 3 death death NN cord-005453-4057qib7 16220 4 were be VBD cord-005453-4057qib7 16220 5 : : : cord-005453-4057qib7 16220 6 infection infection NN cord-005453-4057qib7 16220 7 45 45 CD cord-005453-4057qib7 16220 8 % % NN cord-005453-4057qib7 16221 1 Relapse relapse NN cord-005453-4057qib7 16221 2 30 30 CD cord-005453-4057qib7 16221 3 % % NN cord-005453-4057qib7 16221 4 , , , cord-005453-4057qib7 16221 5 Hemorrhage hemorrhage NN cord-005453-4057qib7 16221 6 20 20 CD cord-005453-4057qib7 16221 7 % % NN cord-005453-4057qib7 16221 8 and and CC cord-005453-4057qib7 16221 9 GVHD GVHD NNP cord-005453-4057qib7 16221 10 5 5 CD cord-005453-4057qib7 16221 11 % % NN cord-005453-4057qib7 16221 12 . . . cord-005453-4057qib7 16222 1 The the DT cord-005453-4057qib7 16222 2 CBSCT CBSCT NNP cord-005453-4057qib7 16222 3 continues continue VBZ cord-005453-4057qib7 16222 4 to to TO cord-005453-4057qib7 16222 5 be be VB cord-005453-4057qib7 16222 6 an an DT cord-005453-4057qib7 16222 7 essential essential JJ cord-005453-4057qib7 16222 8 alternative alternative NN cord-005453-4057qib7 16222 9 in in IN cord-005453-4057qib7 16222 10 our -PRON- PRP$ cord-005453-4057qib7 16222 11 patients patient NNS cord-005453-4057qib7 16222 12 who who WP cord-005453-4057qib7 16222 13 required require VBD cord-005453-4057qib7 16222 14 transplantation transplantation NN cord-005453-4057qib7 16222 15 knowing know VBG cord-005453-4057qib7 16222 16 that that IN cord-005453-4057qib7 16222 17 this this DT cord-005453-4057qib7 16222 18 stem stem NN cord-005453-4057qib7 16222 19 cell cell NN cord-005453-4057qib7 16222 20 source source NN cord-005453-4057qib7 16222 21 allows allow VBZ cord-005453-4057qib7 16222 22 the the DT cord-005453-4057qib7 16222 23 procedure procedure NN cord-005453-4057qib7 16222 24 to to TO cord-005453-4057qib7 16222 25 be be VB cord-005453-4057qib7 16222 26 done do VBN cord-005453-4057qib7 16222 27 with with IN cord-005453-4057qib7 16222 28 less less JJR cord-005453-4057qib7 16222 29 histocompatibility histocompatibility NN cord-005453-4057qib7 16222 30 requirements requirement NNS cord-005453-4057qib7 16222 31 and and CC cord-005453-4057qib7 16222 32 it -PRON- PRP cord-005453-4057qib7 16222 33 is be VBZ cord-005453-4057qib7 16222 34 available available JJ cord-005453-4057qib7 16222 35 immediately immediately RB cord-005453-4057qib7 16222 36 , , , cord-005453-4057qib7 16222 37 which which WDT cord-005453-4057qib7 16222 38 facilitates facilitate VBZ cord-005453-4057qib7 16222 39 the the DT cord-005453-4057qib7 16222 40 process process NN cord-005453-4057qib7 16222 41 considering consider VBG cord-005453-4057qib7 16222 42 the the DT cord-005453-4057qib7 16222 43 great great JJ cord-005453-4057qib7 16222 44 diversity diversity NN cord-005453-4057qib7 16222 45 that that WDT cord-005453-4057qib7 16222 46 exists exist VBZ cord-005453-4057qib7 16222 47 within within IN cord-005453-4057qib7 16222 48 our -PRON- PRP$ cord-005453-4057qib7 16222 49 population population NN cord-005453-4057qib7 16222 50 . . . cord-005453-4057qib7 16223 1 However however RB cord-005453-4057qib7 16223 2 , , , cord-005453-4057qib7 16223 3 in in IN cord-005453-4057qib7 16223 4 our -PRON- PRP$ cord-005453-4057qib7 16223 5 experience experience NN cord-005453-4057qib7 16223 6 , , , cord-005453-4057qib7 16223 7 the the DT cord-005453-4057qib7 16223 8 CBSCT CBSCT NNP cord-005453-4057qib7 16223 9 has have VBZ cord-005453-4057qib7 16223 10 shown show VBN cord-005453-4057qib7 16223 11 a a DT cord-005453-4057qib7 16223 12 higher high JJR cord-005453-4057qib7 16223 13 mortality mortality NN cord-005453-4057qib7 16223 14 risk risk NN cord-005453-4057qib7 16223 15 , , , cord-005453-4057qib7 16223 16 which which WDT cord-005453-4057qib7 16223 17 can can MD cord-005453-4057qib7 16223 18 be be VB cord-005453-4057qib7 16223 19 improved improve VBN cord-005453-4057qib7 16223 20 by by IN cord-005453-4057qib7 16223 21 analyzing analyze VBG cord-005453-4057qib7 16223 22 the the DT cord-005453-4057qib7 16223 23 HLA HLA NNP cord-005453-4057qib7 16223 24 C C NNP cord-005453-4057qib7 16223 25 , , , cord-005453-4057qib7 16223 26 choosing choose VBG cord-005453-4057qib7 16223 27 in in IN cord-005453-4057qib7 16223 28 this this DT cord-005453-4057qib7 16223 29 way way NN cord-005453-4057qib7 16223 30 the the DT cord-005453-4057qib7 16223 31 units unit NNS cord-005453-4057qib7 16223 32 with with IN cord-005453-4057qib7 16223 33 better well JJR cord-005453-4057qib7 16223 34 compatibility compatibility NN cord-005453-4057qib7 16223 35 , , , cord-005453-4057qib7 16223 36 and and CC cord-005453-4057qib7 16223 37 improving improve VBG cord-005453-4057qib7 16223 38 cellular cellular JJ cord-005453-4057qib7 16223 39 dosage dosage NN cord-005453-4057qib7 16223 40 since since IN cord-005453-4057qib7 16223 41 this this DT cord-005453-4057qib7 16223 42 is be VBZ cord-005453-4057qib7 16223 43 key key JJ cord-005453-4057qib7 16223 44 in in IN cord-005453-4057qib7 16223 45 success success NN cord-005453-4057qib7 16223 46 . . . cord-005453-4057qib7 16224 1 Disclosure disclosure NN cord-005453-4057qib7 16224 2 : : : cord-005453-4057qib7 16224 3 nothing nothing NN cord-005453-4057qib7 16224 4 to to TO cord-005453-4057qib7 16224 5 declare declare VB cord-005453-4057qib7 16224 6 The the DT cord-005453-4057qib7 16224 7 risk risk NN cord-005453-4057qib7 16224 8 of of IN cord-005453-4057qib7 16224 9 infection infection NN cord-005453-4057qib7 16224 10 of of IN cord-005453-4057qib7 16224 11 the the DT cord-005453-4057qib7 16224 12 umbilical umbilical JJ cord-005453-4057qib7 16224 13 cord cord NN cord-005453-4057qib7 16224 14 is be VBZ cord-005453-4057qib7 16224 15 not not RB cord-005453-4057qib7 16224 16 related relate VBN cord-005453-4057qib7 16224 17 to to IN cord-005453-4057qib7 16224 18 the the DT cord-005453-4057qib7 16224 19 microbiological microbiological JJ cord-005453-4057qib7 16224 20 status status NN cord-005453-4057qib7 16224 21 of of IN cord-005453-4057qib7 16224 22 the the DT cord-005453-4057qib7 16224 23 umbilical umbilical JJ cord-005453-4057qib7 16224 24 cord cord NN cord-005453-4057qib7 16224 25 blood blood NN cord-005453-4057qib7 16224 26 Methods method NNS cord-005453-4057qib7 16224 27 : : : cord-005453-4057qib7 16224 28 The the DT cord-005453-4057qib7 16224 29 statistical statistical JJ cord-005453-4057qib7 16224 30 analysis analysis NN cord-005453-4057qib7 16224 31 was be VBD cord-005453-4057qib7 16224 32 carried carry VBN cord-005453-4057qib7 16224 33 out out RP cord-005453-4057qib7 16224 34 on on IN cord-005453-4057qib7 16224 35 data datum NNS cord-005453-4057qib7 16224 36 obtained obtain VBN cord-005453-4057qib7 16224 37 from from IN cord-005453-4057qib7 16224 38 samples sample NNS cord-005453-4057qib7 16224 39 taken take VBN cord-005453-4057qib7 16224 40 in in IN cord-005453-4057qib7 16224 41 Poland Poland NNP cord-005453-4057qib7 16224 42 between between IN cord-005453-4057qib7 16224 43 01-Jan-2017 01-Jan-2017 NNP cord-005453-4057qib7 16224 44 and and CC cord-005453-4057qib7 16224 45 31-Dec-2017 31-Dec-2017 NNP cord-005453-4057qib7 16224 46 . . . cord-005453-4057qib7 16225 1 The the DT cord-005453-4057qib7 16225 2 samples sample NNS cord-005453-4057qib7 16225 3 were be VBD cord-005453-4057qib7 16225 4 collected collect VBN cord-005453-4057qib7 16225 5 in in IN cord-005453-4057qib7 16225 6 hospitals hospital NNS cord-005453-4057qib7 16225 7 by by IN cord-005453-4057qib7 16225 8 external external JJ cord-005453-4057qib7 16225 9 midwifes midwife NNS cord-005453-4057qib7 16225 10 and and CC cord-005453-4057qib7 16225 11 sent send VBN cord-005453-4057qib7 16225 12 to to IN cord-005453-4057qib7 16225 13 the the DT cord-005453-4057qib7 16225 14 PBKM PBKM NNP cord-005453-4057qib7 16225 15 in in IN cord-005453-4057qib7 16225 16 accordance accordance NN cord-005453-4057qib7 16225 17 with with IN cord-005453-4057qib7 16225 18 the the DT cord-005453-4057qib7 16225 19 requirements requirement NNS cord-005453-4057qib7 16225 20 of of IN cord-005453-4057qib7 16225 21 the the DT cord-005453-4057qib7 16225 22 American American NNP cord-005453-4057qib7 16225 23 Association Association NNP cord-005453-4057qib7 16225 24 of of IN cord-005453-4057qib7 16225 25 Blood Blood NNP cord-005453-4057qib7 16225 26 Banks Banks NNPS cord-005453-4057qib7 16225 27 . . . cord-005453-4057qib7 16226 1 After after IN cord-005453-4057qib7 16226 2 arrival arrival NN cord-005453-4057qib7 16226 3 in in IN cord-005453-4057qib7 16226 4 the the DT cord-005453-4057qib7 16226 5 laboratory laboratory NN cord-005453-4057qib7 16226 6 , , , cord-005453-4057qib7 16226 7 the the DT cord-005453-4057qib7 16226 8 blood blood NN cord-005453-4057qib7 16226 9 samples sample NNS cord-005453-4057qib7 16226 10 were be VBD cord-005453-4057qib7 16226 11 cultured cultured JJ cord-005453-4057qib7 16226 12 and and CC cord-005453-4057qib7 16226 13 the the DT cord-005453-4057qib7 16226 14 UCs uc NNS cord-005453-4057qib7 16226 15 were be VBD cord-005453-4057qib7 16226 16 assessed assess VBN cord-005453-4057qib7 16226 17 immediately immediately RB cord-005453-4057qib7 16226 18 for for IN cord-005453-4057qib7 16226 19 visual visual JJ cord-005453-4057qib7 16226 20 signs sign NNS cord-005453-4057qib7 16226 21 of of IN cord-005453-4057qib7 16226 22 infection infection NN cord-005453-4057qib7 16226 23 , , , cord-005453-4057qib7 16226 24 such such JJ cord-005453-4057qib7 16226 25 as as IN cord-005453-4057qib7 16226 26 odor odor NN cord-005453-4057qib7 16226 27 , , , cord-005453-4057qib7 16226 28 altered alter VBN cord-005453-4057qib7 16226 29 color color NN cord-005453-4057qib7 16226 30 , , , cord-005453-4057qib7 16226 31 or or CC cord-005453-4057qib7 16226 32 visible visible JJ cord-005453-4057qib7 16226 33 bloom bloom NN cord-005453-4057qib7 16226 34 . . . cord-005453-4057qib7 16227 1 The the DT cord-005453-4057qib7 16227 2 status status NN cord-005453-4057qib7 16227 3 of of IN cord-005453-4057qib7 16227 4 both both DT cord-005453-4057qib7 16227 5 kinds kind NNS cord-005453-4057qib7 16227 6 of of IN cord-005453-4057qib7 16227 7 samples sample NNS cord-005453-4057qib7 16227 8 was be VBD cord-005453-4057qib7 16227 9 introduced introduce VBN cord-005453-4057qib7 16227 10 into into IN cord-005453-4057qib7 16227 11 the the DT cord-005453-4057qib7 16227 12 PBKM PBKM NNP cord-005453-4057qib7 16227 13 general general JJ cord-005453-4057qib7 16227 14 database database NN cord-005453-4057qib7 16227 15 . . . cord-005453-4057qib7 16228 1 For for IN cord-005453-4057qib7 16228 2 the the DT cord-005453-4057qib7 16228 3 purpose purpose NN cord-005453-4057qib7 16228 4 of of IN cord-005453-4057qib7 16228 5 this this DT cord-005453-4057qib7 16228 6 analysis analysis NN cord-005453-4057qib7 16228 7 , , , cord-005453-4057qib7 16228 8 the the DT cord-005453-4057qib7 16228 9 UCs uc NNS cord-005453-4057qib7 16228 10 were be VBD cord-005453-4057qib7 16228 11 considered consider VBN cord-005453-4057qib7 16228 12 as as RB cord-005453-4057qib7 16228 13 microbiologically microbiologically RB cord-005453-4057qib7 16228 14 pure pure JJ cord-005453-4057qib7 16228 15 if if IN cord-005453-4057qib7 16228 16 stored store VBN cord-005453-4057qib7 16228 17 , , , cord-005453-4057qib7 16228 18 destroyed destroy VBN cord-005453-4057qib7 16228 19 after after IN cord-005453-4057qib7 16228 20 storage storage NN cord-005453-4057qib7 16228 21 , , , cord-005453-4057qib7 16228 22 or or CC cord-005453-4057qib7 16228 23 handed hand VBN cord-005453-4057qib7 16228 24 over over RP cord-005453-4057qib7 16228 25 to to IN cord-005453-4057qib7 16228 26 the the DT cord-005453-4057qib7 16228 27 PBKM PBKM NNP cord-005453-4057qib7 16228 28 . . . cord-005453-4057qib7 16229 1 Samples sample NNS cord-005453-4057qib7 16229 2 marked mark VBN cord-005453-4057qib7 16229 3 as as IN cord-005453-4057qib7 16229 4 infected infect VBN cord-005453-4057qib7 16229 5 or or CC cord-005453-4057qib7 16229 6 disqualified disqualify VBN cord-005453-4057qib7 16229 7 for for IN cord-005453-4057qib7 16229 8 unknown unknown JJ cord-005453-4057qib7 16229 9 reasons reason NNS cord-005453-4057qib7 16229 10 ( ( -LRB- cord-005453-4057qib7 16229 11 other other JJ cord-005453-4057qib7 16229 12 than than IN cord-005453-4057qib7 16229 13 termination termination NN cord-005453-4057qib7 16229 14 of of IN cord-005453-4057qib7 16229 15 the the DT cord-005453-4057qib7 16229 16 contract contract NN cord-005453-4057qib7 16229 17 with with IN cord-005453-4057qib7 16229 18 the the DT cord-005453-4057qib7 16229 19 customer customer NN cord-005453-4057qib7 16229 20 , , , cord-005453-4057qib7 16229 21 viral viral JJ cord-005453-4057qib7 16229 22 infection infection NN cord-005453-4057qib7 16229 23 of of IN cord-005453-4057qib7 16229 24 the the DT cord-005453-4057qib7 16229 25 mother mother NN cord-005453-4057qib7 16229 26 , , , cord-005453-4057qib7 16229 27 and and CC cord-005453-4057qib7 16229 28 lack lack NN cord-005453-4057qib7 16229 29 of of IN cord-005453-4057qib7 16229 30 cell cell NN cord-005453-4057qib7 16229 31 growth growth NN cord-005453-4057qib7 16229 32 ) ) -RRB- cord-005453-4057qib7 16229 33 were be VBD cord-005453-4057qib7 16229 34 considered consider VBN cord-005453-4057qib7 16229 35 as as IN cord-005453-4057qib7 16229 36 infected infect VBN cord-005453-4057qib7 16229 37 . . . cord-005453-4057qib7 16230 1 At at IN cord-005453-4057qib7 16230 2 the the DT cord-005453-4057qib7 16230 3 time time NN cord-005453-4057qib7 16230 4 of of IN cord-005453-4057qib7 16230 5 the the DT cord-005453-4057qib7 16230 6 statistical statistical JJ cord-005453-4057qib7 16230 7 analysis analysis NN cord-005453-4057qib7 16230 8 , , , cord-005453-4057qib7 16230 9 the the DT cord-005453-4057qib7 16230 10 samples sample NNS cord-005453-4057qib7 16230 11 of of IN cord-005453-4057qib7 16230 12 unknown unknown JJ cord-005453-4057qib7 16230 13 UCB UCB NNP cord-005453-4057qib7 16230 14 microbiological microbiological JJ cord-005453-4057qib7 16230 15 culture culture NN cord-005453-4057qib7 16230 16 status status NN cord-005453-4057qib7 16230 17 were be VBD cord-005453-4057qib7 16230 18 removed remove VBN cord-005453-4057qib7 16230 19 from from IN cord-005453-4057qib7 16230 20 the the DT cord-005453-4057qib7 16230 21 generated generate VBN cord-005453-4057qib7 16230 22 report report NN cord-005453-4057qib7 16230 23 . . . cord-005453-4057qib7 16231 1 The the DT cord-005453-4057qib7 16231 2 data datum NNS cord-005453-4057qib7 16231 3 was be VBD cord-005453-4057qib7 16231 4 summarized summarize VBN cord-005453-4057qib7 16231 5 as as IN cord-005453-4057qib7 16231 6 percentages percentage NNS cord-005453-4057qib7 16231 7 and and CC cord-005453-4057qib7 16231 8 the the DT cord-005453-4057qib7 16231 9 odds odd NNS cord-005453-4057qib7 16231 10 ratio ratio NN cord-005453-4057qib7 16231 11 was be VBD cord-005453-4057qib7 16231 12 calculated calculate VBN cord-005453-4057qib7 16231 13 . . . cord-005453-4057qib7 16232 1 Statistical statistical JJ cord-005453-4057qib7 16232 2 significance significance NN cord-005453-4057qib7 16232 3 was be VBD cord-005453-4057qib7 16232 4 considered consider VBN cord-005453-4057qib7 16232 5 at at IN cord-005453-4057qib7 16232 6 p˂0.05.Background p˂0.05.background NN cord-005453-4057qib7 16232 7 : : : cord-005453-4057qib7 16233 1 Match match VB cord-005453-4057qib7 16233 2 family family NN cord-005453-4057qib7 16233 3 donors donor NNS cord-005453-4057qib7 16233 4 are be VBP cord-005453-4057qib7 16233 5 the the DT cord-005453-4057qib7 16233 6 preferable preferable JJ cord-005453-4057qib7 16233 7 options option NNS cord-005453-4057qib7 16233 8 in in IN cord-005453-4057qib7 16233 9 allogenic allogenic JJ cord-005453-4057qib7 16233 10 stem stem NN cord-005453-4057qib7 16233 11 cell cell NN cord-005453-4057qib7 16233 12 transplant transplant NN cord-005453-4057qib7 16233 13 . . . cord-005453-4057qib7 16234 1 However however RB cord-005453-4057qib7 16234 2 , , , cord-005453-4057qib7 16234 3 in in IN cord-005453-4057qib7 16234 4 the the DT cord-005453-4057qib7 16234 5 absence absence NN cord-005453-4057qib7 16234 6 of of IN cord-005453-4057qib7 16234 7 donor donor NN cord-005453-4057qib7 16234 8 relatives relative NNS cord-005453-4057qib7 16234 9 match match VBP cord-005453-4057qib7 16234 10 unrelated unrelated JJ cord-005453-4057qib7 16234 11 donors donor NNS cord-005453-4057qib7 16234 12 have have VBP cord-005453-4057qib7 16234 13 been be VBN cord-005453-4057qib7 16234 14 an an DT cord-005453-4057qib7 16234 15 option option NN cord-005453-4057qib7 16234 16 . . . cord-005453-4057qib7 16235 1 In in IN cord-005453-4057qib7 16235 2 this this DT cord-005453-4057qib7 16235 3 study study NN cord-005453-4057qib7 16235 4 , , , cord-005453-4057qib7 16235 5 the the DT cord-005453-4057qib7 16235 6 donor donor NN cord-005453-4057qib7 16235 7 screening screening NN cord-005453-4057qib7 16235 8 , , , cord-005453-4057qib7 16235 9 transplant transplant NN cord-005453-4057qib7 16235 10 preparation preparation NN cord-005453-4057qib7 16235 11 phases phase NNS cord-005453-4057qib7 16235 12 of of IN cord-005453-4057qib7 16235 13 Turkish turkish JJ cord-005453-4057qib7 16235 14 Stem Stem NNP cord-005453-4057qib7 16235 15 Cell Cell NNP cord-005453-4057qib7 16235 16 Coordination Coordination NNP cord-005453-4057qib7 16235 17 Center Center NNP cord-005453-4057qib7 16235 18 ( ( -LRB- cord-005453-4057qib7 16235 19 TURKOK TURKOK NNP cord-005453-4057qib7 16235 20 ) ) -RRB- cord-005453-4057qib7 16235 21 and and CC cord-005453-4057qib7 16235 22 the the DT cord-005453-4057qib7 16235 23 İstanbul İstanbul NNP cord-005453-4057qib7 16235 24 University University NNP cord-005453-4057qib7 16235 25 Bone Bone NNP cord-005453-4057qib7 16235 26 Marrow Marrow NNP cord-005453-4057qib7 16235 27 Bank Bank NNP cord-005453-4057qib7 16235 28 ( ( -LRB- cord-005453-4057qib7 16235 29 TRIS TRIS NNP cord-005453-4057qib7 16235 30 ) ) -RRB- cord-005453-4057qib7 16235 31 , , , cord-005453-4057qib7 16235 32 were be VBD cord-005453-4057qib7 16235 33 compared compare VBN cord-005453-4057qib7 16235 34 . . . cord-005453-4057qib7 16236 1 Methods method NNS cord-005453-4057qib7 16236 2 : : : cord-005453-4057qib7 16236 3 The the DT cord-005453-4057qib7 16236 4 unrelated unrelated JJ cord-005453-4057qib7 16236 5 donor donor NN cord-005453-4057qib7 16236 6 scanning scanning NN cord-005453-4057qib7 16236 7 data datum NNS cord-005453-4057qib7 16236 8 between between IN cord-005453-4057qib7 16236 9 March March NNP cord-005453-4057qib7 16236 10 2015 2015 CD cord-005453-4057qib7 16236 11 and and CC cord-005453-4057qib7 16236 12 November November NNP cord-005453-4057qib7 16236 13 2018 2018 CD cord-005453-4057qib7 16236 14 in in IN cord-005453-4057qib7 16236 15 Pediatric pediatric JJ cord-005453-4057qib7 16236 16 stem stem NN cord-005453-4057qib7 16236 17 cell cell NN cord-005453-4057qib7 16236 18 transplantation transplantation NN cord-005453-4057qib7 16236 19 Unit Unit NNP cord-005453-4057qib7 16236 20 of of IN cord-005453-4057qib7 16236 21 Altınbas Altınbas NNP cord-005453-4057qib7 16236 22 University University NNP cord-005453-4057qib7 16236 23 Bahcelievler Bahcelievler NNP cord-005453-4057qib7 16236 24 Medical Medical NNP cord-005453-4057qib7 16236 25 Park Park NNP cord-005453-4057qib7 16236 26 Hospital Hospital NNP cord-005453-4057qib7 16236 27 were be VBD cord-005453-4057qib7 16236 28 evaluated evaluate VBN cord-005453-4057qib7 16236 29 . . . cord-005453-4057qib7 16237 1 93 93 CD cord-005453-4057qib7 16237 2 unrelated unrelated JJ cord-005453-4057qib7 16237 3 transplants transplant NNS cord-005453-4057qib7 16237 4 were be VBD cord-005453-4057qib7 16237 5 performed perform VBN cord-005453-4057qib7 16237 6 in in IN cord-005453-4057qib7 16237 7 total total NN cord-005453-4057qib7 16237 8 . . . cord-005453-4057qib7 16238 1 65 65 CD cord-005453-4057qib7 16238 2 % % NN cord-005453-4057qib7 16238 3 of of IN cord-005453-4057qib7 16238 4 these these DT cord-005453-4057qib7 16238 5 transplants transplant NNS cord-005453-4057qib7 16238 6 ( ( -LRB- cord-005453-4057qib7 16238 7 n=61 n=61 NNP cord-005453-4057qib7 16238 8 ) ) -RRB- cord-005453-4057qib7 16238 9 were be VBD cord-005453-4057qib7 16238 10 included include VBN cord-005453-4057qib7 16238 11 from from IN cord-005453-4057qib7 16238 12 the the DT cord-005453-4057qib7 16238 13 donors donor NNS cord-005453-4057qib7 16238 14 of of IN cord-005453-4057qib7 16238 15 TURKOK TURKOK NNP cord-005453-4057qib7 16238 16 registration registration NN cord-005453-4057qib7 16238 17 system system NN cord-005453-4057qib7 16238 18 and and CC cord-005453-4057qib7 16238 19 34,4 34,4 CD cord-005453-4057qib7 16238 20 % % NN cord-005453-4057qib7 16238 21 of of IN cord-005453-4057qib7 16238 22 these these DT cord-005453-4057qib7 16238 23 transplants transplant NNS cord-005453-4057qib7 16238 24 ( ( -LRB- cord-005453-4057qib7 16238 25 n=32 n=32 NNP cord-005453-4057qib7 16238 26 ) ) -RRB- cord-005453-4057qib7 16238 27 were be VBD cord-005453-4057qib7 16238 28 included include VBN cord-005453-4057qib7 16238 29 by by IN cord-005453-4057qib7 16238 30 means mean NNS cord-005453-4057qib7 16238 31 of of IN cord-005453-4057qib7 16238 32 TRIS TRIS NNP cord-005453-4057qib7 16238 33 from from IN cord-005453-4057qib7 16238 34 donors donor NNS cord-005453-4057qib7 16238 35 outside outside IN cord-005453-4057qib7 16238 36 of of IN cord-005453-4057qib7 16238 37 Turkey Turkey NNP cord-005453-4057qib7 16238 38 . . . cord-005453-4057qib7 16239 1 8 8 CD cord-005453-4057qib7 16239 2 patients patient NNS cord-005453-4057qib7 16239 3 ( ( -LRB- cord-005453-4057qib7 16239 4 5 5 CD cord-005453-4057qib7 16239 5 TRIS TRIS NNP cord-005453-4057qib7 16239 6 , , , cord-005453-4057qib7 16239 7 3 3 CD cord-005453-4057qib7 16239 8 TURKOK TURKOK NNP cord-005453-4057qib7 16239 9 ) ) -RRB- cord-005453-4057qib7 16239 10 were be VBD cord-005453-4057qib7 16239 11 excluded exclude VBN cord-005453-4057qib7 16239 12 from from IN cord-005453-4057qib7 16239 13 the the DT cord-005453-4057qib7 16239 14 study study NN cord-005453-4057qib7 16239 15 in in IN cord-005453-4057qib7 16239 16 consequence consequence NN cord-005453-4057qib7 16239 17 of of IN cord-005453-4057qib7 16239 18 screening screening NN cord-005453-4057qib7 16239 19 update update NN cord-005453-4057qib7 16239 20 and and CC cord-005453-4057qib7 16239 21 postpone postpone NN cord-005453-4057qib7 16239 22 of of IN cord-005453-4057qib7 16239 23 transplantation transplantation NN cord-005453-4057qib7 16239 24 . . . cord-005453-4057qib7 16240 1 The the DT cord-005453-4057qib7 16240 2 statistics statistic NNS cord-005453-4057qib7 16240 3 were be VBD cord-005453-4057qib7 16240 4 carried carry VBN cord-005453-4057qib7 16240 5 out out RP cord-005453-4057qib7 16240 6 on on IN cord-005453-4057qib7 16240 7 a a DT cord-005453-4057qib7 16240 8 total total NN cord-005453-4057qib7 16240 9 of of IN cord-005453-4057qib7 16240 10 85 85 CD cord-005453-4057qib7 16240 11 patients patient NNS cord-005453-4057qib7 16240 12 , , , cord-005453-4057qib7 16240 13 67,1 67,1 CD cord-005453-4057qib7 16240 14 % % NN cord-005453-4057qib7 16240 15 of of IN cord-005453-4057qib7 16240 16 whom whom WP cord-005453-4057qib7 16240 17 were be VBD cord-005453-4057qib7 16240 18 in in IN cord-005453-4057qib7 16240 19 TURKOK TURKOK NNP cord-005453-4057qib7 16240 20 ( ( -LRB- cord-005453-4057qib7 16240 21 n=57 n=57 NNP cord-005453-4057qib7 16240 22 ) ) -RRB- cord-005453-4057qib7 16240 23 and and CC cord-005453-4057qib7 16240 24 32,9 32,9 CD cord-005453-4057qib7 16240 25 % % NN cord-005453-4057qib7 16240 26 were be VBD cord-005453-4057qib7 16240 27 transplanted transplant VBN cord-005453-4057qib7 16240 28 via via IN cord-005453-4057qib7 16240 29 TRIS TRIS NNP cord-005453-4057qib7 16240 30 ( ( -LRB- cord-005453-4057qib7 16240 31 n=28 n=28 NN cord-005453-4057qib7 16240 32 ) ) -RRB- cord-005453-4057qib7 16240 33 . . . cord-005453-4057qib7 16241 1 The the DT cord-005453-4057qib7 16241 2 day day NN cord-005453-4057qib7 16241 3 of of IN cord-005453-4057qib7 16241 4 application application NN cord-005453-4057qib7 16241 5 to to TO cord-005453-4057qib7 16241 6 stem stem VB cord-005453-4057qib7 16241 7 cell cell NN cord-005453-4057qib7 16241 8 transplantation transplantation NN cord-005453-4057qib7 16241 9 unit unit NN cord-005453-4057qib7 16241 10 , , , cord-005453-4057qib7 16241 11 reply reply NN cord-005453-4057qib7 16241 12 dates date NNS cord-005453-4057qib7 16241 13 and and CC cord-005453-4057qib7 16241 14 the the DT cord-005453-4057qib7 16241 15 transplantation transplantation NN cord-005453-4057qib7 16241 16 dates date NNS cord-005453-4057qib7 16241 17 were be VBD cord-005453-4057qib7 16241 18 examined examine VBN cord-005453-4057qib7 16241 19 for for IN cord-005453-4057qib7 16241 20 the the DT cord-005453-4057qib7 16241 21 transplant transplant NN cord-005453-4057qib7 16241 22 patients patient NNS cord-005453-4057qib7 16241 23 . . . cord-005453-4057qib7 16242 1 Results result NNS cord-005453-4057qib7 16242 2 : : : cord-005453-4057qib7 16243 1 In in IN cord-005453-4057qib7 16243 2 the the DT cord-005453-4057qib7 16243 3 current current JJ cord-005453-4057qib7 16243 4 study study NN cord-005453-4057qib7 16243 5 , , , cord-005453-4057qib7 16243 6 the the DT cord-005453-4057qib7 16243 7 average average JJ cord-005453-4057qib7 16243 8 response response NN cord-005453-4057qib7 16243 9 time time NN cord-005453-4057qib7 16243 10 of of IN cord-005453-4057qib7 16243 11 TURKOK TURKOK NNP cord-005453-4057qib7 16243 12 was be VBD cord-005453-4057qib7 16243 13 found find VBN cord-005453-4057qib7 16243 14 as as IN cord-005453-4057qib7 16243 15 0,91±2,96 0,91±2,96 CD cord-005453-4057qib7 16243 16 day day NN cord-005453-4057qib7 16243 17 ( ( -LRB- cord-005453-4057qib7 16243 18 median median NN cord-005453-4057qib7 16243 19 : : SYM cord-005453-4057qib7 16243 20 0 0 CD cord-005453-4057qib7 16243 21 ) ) -RRB- cord-005453-4057qib7 16243 22 , , , cord-005453-4057qib7 16243 23 the the DT cord-005453-4057qib7 16243 24 average average JJ cord-005453-4057qib7 16243 25 transplant transplant NN cord-005453-4057qib7 16243 26 time time NN cord-005453-4057qib7 16243 27 after after IN cord-005453-4057qib7 16243 28 receiving receive VBG cord-005453-4057qib7 16243 29 a a DT cord-005453-4057qib7 16243 30 reply reply NN cord-005453-4057qib7 16243 31 was be VBD cord-005453-4057qib7 16243 32 found find VBN cord-005453-4057qib7 16243 33 as as IN cord-005453-4057qib7 16243 34 98,24±63,89 98,24±63,89 CD cord-005453-4057qib7 16243 35 ( ( -LRB- cord-005453-4057qib7 16243 36 median median NN cord-005453-4057qib7 16243 37 : : : cord-005453-4057qib7 16243 38 85 85 CD cord-005453-4057qib7 16243 39 ) ) -RRB- cord-005453-4057qib7 16243 40 day day NN cord-005453-4057qib7 16243 41 , , , cord-005453-4057qib7 16243 42 the the DT cord-005453-4057qib7 16243 43 average average JJ cord-005453-4057qib7 16243 44 number number NN cord-005453-4057qib7 16243 45 of of IN cord-005453-4057qib7 16243 46 days day NNS cord-005453-4057qib7 16243 47 from from IN cord-005453-4057qib7 16243 48 date date NN cord-005453-4057qib7 16243 49 of of IN cord-005453-4057qib7 16243 50 application application NN cord-005453-4057qib7 16243 51 to to IN cord-005453-4057qib7 16243 52 date date NN cord-005453-4057qib7 16243 53 of of IN cord-005453-4057qib7 16243 54 transplantation transplantation NN cord-005453-4057qib7 16243 55 of of IN cord-005453-4057qib7 16243 56 patients patient NNS cord-005453-4057qib7 16243 57 was be VBD cord-005453-4057qib7 16243 58 found find VBN cord-005453-4057qib7 16243 59 as as IN cord-005453-4057qib7 16243 60 101,12±63,17 101,12±63,17 NNP cord-005453-4057qib7 16243 61 ( ( -LRB- cord-005453-4057qib7 16243 62 median median NN cord-005453-4057qib7 16243 63 : : : cord-005453-4057qib7 16243 64 89 89 CD cord-005453-4057qib7 16243 65 ) ) -RRB- cord-005453-4057qib7 16243 66 . . . cord-005453-4057qib7 16244 1 The the DT cord-005453-4057qib7 16244 2 average average JJ cord-005453-4057qib7 16244 3 response response NN cord-005453-4057qib7 16244 4 time time NN cord-005453-4057qib7 16244 5 of of IN cord-005453-4057qib7 16244 6 TRIS TRIS NNP cord-005453-4057qib7 16244 7 was be VBD cord-005453-4057qib7 16244 8 18,78±18,36 18,78±18,36 CD cord-005453-4057qib7 16245 1 ( ( -LRB- cord-005453-4057qib7 16245 2 median median NN cord-005453-4057qib7 16245 3 : : : cord-005453-4057qib7 16245 4 15 15 CD cord-005453-4057qib7 16245 5 ) ) -RRB- cord-005453-4057qib7 16245 6 day day NN cord-005453-4057qib7 16245 7 , , , cord-005453-4057qib7 16245 8 the the DT cord-005453-4057qib7 16245 9 average average JJ cord-005453-4057qib7 16245 10 transplant transplant NN cord-005453-4057qib7 16245 11 time time NN cord-005453-4057qib7 16245 12 after after IN cord-005453-4057qib7 16245 13 receiving receive VBG cord-005453-4057qib7 16245 14 a a DT cord-005453-4057qib7 16245 15 reply reply NN cord-005453-4057qib7 16245 16 from from IN cord-005453-4057qib7 16245 17 TRIS TRIS NNP cord-005453-4057qib7 16245 18 was be VBD cord-005453-4057qib7 16245 19 136,82±63,84 136,82±63,84 CD cord-005453-4057qib7 16246 1 ( ( -LRB- cord-005453-4057qib7 16246 2 Median median NN cord-005453-4057qib7 16246 3 : : : cord-005453-4057qib7 16246 4 119 119 CD cord-005453-4057qib7 16246 5 ) ) -RRB- cord-005453-4057qib7 16246 6 day day NN cord-005453-4057qib7 16246 7 , , , cord-005453-4057qib7 16246 8 average average JJ cord-005453-4057qib7 16246 9 number number NN cord-005453-4057qib7 16246 10 of of IN cord-005453-4057qib7 16246 11 days day NNS cord-005453-4057qib7 16246 12 from from IN cord-005453-4057qib7 16246 13 date date NN cord-005453-4057qib7 16246 14 of of IN cord-005453-4057qib7 16246 15 application application NN cord-005453-4057qib7 16246 16 of of IN cord-005453-4057qib7 16246 17 TRIS TRIS NNP cord-005453-4057qib7 16246 18 to to IN cord-005453-4057qib7 16246 19 date date NN cord-005453-4057qib7 16246 20 of of IN cord-005453-4057qib7 16246 21 transplantation transplantation NN cord-005453-4057qib7 16246 22 of of IN cord-005453-4057qib7 16246 23 patients patient NNS cord-005453-4057qib7 16247 1 155,61±72,23 155,61±72,23 CD cord-005453-4057qib7 16248 1 ( ( -LRB- cord-005453-4057qib7 16248 2 Median median NN cord-005453-4057qib7 16248 3 : : : cord-005453-4057qib7 16248 4 140 140 CD cord-005453-4057qib7 16248 5 ) ) -RRB- cord-005453-4057qib7 16248 6 day day NN cord-005453-4057qib7 16248 7 . . . cord-005453-4057qib7 16249 1 The the DT cord-005453-4057qib7 16249 2 average average JJ cord-005453-4057qib7 16249 3 response response NN cord-005453-4057qib7 16249 4 time time NN cord-005453-4057qib7 16249 5 of of IN cord-005453-4057qib7 16249 6 TURKOK TURKOK NNP cord-005453-4057qib7 16249 7 , , , cord-005453-4057qib7 16249 8 the the DT cord-005453-4057qib7 16249 9 average average JJ cord-005453-4057qib7 16249 10 transplant transplant NN cord-005453-4057qib7 16249 11 time time NN cord-005453-4057qib7 16249 12 after after IN cord-005453-4057qib7 16249 13 receiving receive VBG cord-005453-4057qib7 16249 14 a a DT cord-005453-4057qib7 16249 15 reply reply NN cord-005453-4057qib7 16249 16 from from IN cord-005453-4057qib7 16249 17 TURKOK TURKOK NNP cord-005453-4057qib7 16249 18 and and CC cord-005453-4057qib7 16249 19 the the DT cord-005453-4057qib7 16249 20 average average JJ cord-005453-4057qib7 16249 21 number number NN cord-005453-4057qib7 16249 22 of of IN cord-005453-4057qib7 16249 23 days day NNS cord-005453-4057qib7 16249 24 from from IN cord-005453-4057qib7 16249 25 date date NN cord-005453-4057qib7 16249 26 of of IN cord-005453-4057qib7 16249 27 application application NN cord-005453-4057qib7 16249 28 of of IN cord-005453-4057qib7 16249 29 TURKOK TURKOK NNP cord-005453-4057qib7 16249 30 to to IN cord-005453-4057qib7 16249 31 date date NN cord-005453-4057qib7 16249 32 of of IN cord-005453-4057qib7 16249 33 transplantation transplantation NN cord-005453-4057qib7 16249 34 of of IN cord-005453-4057qib7 16249 35 patients patient NNS cord-005453-4057qib7 16249 36 was be VBD cord-005453-4057qib7 16249 37 shorter short JJR cord-005453-4057qib7 16249 38 than than IN cord-005453-4057qib7 16249 39 TRIS TRIS NNP cord-005453-4057qib7 16249 40 . . . cord-005453-4057qib7 16250 1 The the DT cord-005453-4057qib7 16250 2 difference difference NN cord-005453-4057qib7 16250 3 between between IN cord-005453-4057qib7 16250 4 them -PRON- PRP cord-005453-4057qib7 16250 5 was be VBD cord-005453-4057qib7 16250 6 found find VBN cord-005453-4057qib7 16251 1 statistically statistically RB cord-005453-4057qib7 16251 2 significant significant JJ cord-005453-4057qib7 16251 3 ( ( -LRB- cord-005453-4057qib7 16251 4 p p NN cord-005453-4057qib7 16251 5 < < XX cord-005453-4057qib7 16251 6 0.05).Conclusions 0.05).conclusion NNS cord-005453-4057qib7 16251 7 : : : cord-005453-4057qib7 16251 8 In in IN cord-005453-4057qib7 16251 9 this this DT cord-005453-4057qib7 16251 10 study study NN cord-005453-4057qib7 16251 11 , , , cord-005453-4057qib7 16251 12 it -PRON- PRP cord-005453-4057qib7 16251 13 was be VBD cord-005453-4057qib7 16251 14 determined determine VBN cord-005453-4057qib7 16251 15 that that IN cord-005453-4057qib7 16251 16 the the DT cord-005453-4057qib7 16251 17 transplantation transplantation NN cord-005453-4057qib7 16251 18 processes process VBZ cord-005453-4057qib7 16251 19 with with IN cord-005453-4057qib7 16251 20 TURKOK TURKOK NNP cord-005453-4057qib7 16251 21 were be VBD cord-005453-4057qib7 16251 22 progressing progress VBG cord-005453-4057qib7 16251 23 more more RBR cord-005453-4057qib7 16251 24 rapidly rapidly RB cord-005453-4057qib7 16251 25 . . . cord-005453-4057qib7 16252 1 The the DT cord-005453-4057qib7 16252 2 rapid rapid JJ cord-005453-4057qib7 16252 3 progress progress NN cord-005453-4057qib7 16252 4 of of IN cord-005453-4057qib7 16252 5 the the DT cord-005453-4057qib7 16252 6 process process NN cord-005453-4057qib7 16252 7 was be VBD cord-005453-4057qib7 16252 8 attributed attribute VBN cord-005453-4057qib7 16252 9 to to IN cord-005453-4057qib7 16252 10 the the DT cord-005453-4057qib7 16252 11 fact fact NN cord-005453-4057qib7 16252 12 that that IN cord-005453-4057qib7 16252 13 all all DT cord-005453-4057qib7 16252 14 donor donor NN cord-005453-4057qib7 16252 15 HLA HLA NNP cord-005453-4057qib7 16252 16 tissue tissue NN cord-005453-4057qib7 16252 17 groups group NNS cord-005453-4057qib7 16252 18 in in IN cord-005453-4057qib7 16252 19 the the DT cord-005453-4057qib7 16252 20 TURKOK TURKOK NNP cord-005453-4057qib7 16252 21 database database NN cord-005453-4057qib7 16252 22 were be VBD cord-005453-4057qib7 16252 23 studied study VBN cord-005453-4057qib7 16252 24 in in IN cord-005453-4057qib7 16252 25 high high JJ cord-005453-4057qib7 16252 26 resolution resolution NN cord-005453-4057qib7 16252 27 . . . cord-005453-4057qib7 16253 1 In in IN cord-005453-4057qib7 16253 2 international international JJ cord-005453-4057qib7 16253 3 scans scan NNS cord-005453-4057qib7 16253 4 carried carry VBN cord-005453-4057qib7 16253 5 out out RP cord-005453-4057qib7 16253 6 through through IN cord-005453-4057qib7 16253 7 TRIS TRIS NNP cord-005453-4057qib7 16253 8 , , , cord-005453-4057qib7 16253 9 it -PRON- PRP cord-005453-4057qib7 16253 10 was be VBD cord-005453-4057qib7 16253 11 thought think VBN cord-005453-4057qib7 16253 12 that that IN cord-005453-4057qib7 16253 13 the the DT cord-005453-4057qib7 16253 14 examination examination NN cord-005453-4057qib7 16253 15 of of IN cord-005453-4057qib7 16253 16 the the DT cord-005453-4057qib7 16253 17 donor donor NN cord-005453-4057qib7 16253 18 castings casting NNS cord-005453-4057qib7 16253 19 coming come VBG cord-005453-4057qib7 16253 20 from from IN cord-005453-4057qib7 16253 21 bone bone NN cord-005453-4057qib7 16253 22 marrow marrow NN cord-005453-4057qib7 16253 23 banks bank NNS cord-005453-4057qib7 16253 24 and and CC cord-005453-4057qib7 16253 25 the the DT cord-005453-4057qib7 16253 26 time time NN cord-005453-4057qib7 16253 27 differences difference NNS cord-005453-4057qib7 16253 28 between between IN cord-005453-4057qib7 16253 29 the the DT cord-005453-4057qib7 16253 30 countries country NNS cord-005453-4057qib7 16253 31 prolong prolong VBP cord-005453-4057qib7 16253 32 the the DT cord-005453-4057qib7 16253 33 process process NN cord-005453-4057qib7 16253 34 . . . cord-005453-4057qib7 16254 1 It -PRON- PRP cord-005453-4057qib7 16254 2 was be VBD cord-005453-4057qib7 16254 3 thought think VBN cord-005453-4057qib7 16254 4 that that IN cord-005453-4057qib7 16254 5 HLA HLA NNP cord-005453-4057qib7 16254 6 tests test NNS cord-005453-4057qib7 16254 7 of of IN cord-005453-4057qib7 16254 8 the the DT cord-005453-4057qib7 16254 9 registered register VBN cord-005453-4057qib7 16254 10 donors donor NNS cord-005453-4057qib7 16254 11 in in IN cord-005453-4057qib7 16254 12 the the DT cord-005453-4057qib7 16254 13 TRIS TRIS NNP cord-005453-4057qib7 16254 14 database database NN cord-005453-4057qib7 16254 15 and and CC cord-005453-4057qib7 16254 16 some some DT cord-005453-4057qib7 16254 17 international international JJ cord-005453-4057qib7 16254 18 bone bone NN cord-005453-4057qib7 16254 19 marrow marrow NN cord-005453-4057qib7 16254 20 banks bank NNS cord-005453-4057qib7 16254 21 were be VBD cord-005453-4057qib7 16254 22 studied study VBN cord-005453-4057qib7 16254 23 in in IN cord-005453-4057qib7 16254 24 low low JJ cord-005453-4057qib7 16254 25 resolution resolution NN cord-005453-4057qib7 16254 26 but but CC cord-005453-4057qib7 16254 27 not not RB cord-005453-4057qib7 16254 28 studied study VBD cord-005453-4057qib7 16254 29 the the DT cord-005453-4057qib7 16254 30 all all DT cord-005453-4057qib7 16254 31 HLA HLA NNP cord-005453-4057qib7 16254 32 loci locus NNS cord-005453-4057qib7 16254 33 , , , cord-005453-4057qib7 16254 34 the the DT cord-005453-4057qib7 16254 35 centers center NNS cord-005453-4057qib7 16254 36 wanted want VBD cord-005453-4057qib7 16254 37 high high JJ cord-005453-4057qib7 16254 38 - - HYPH cord-005453-4057qib7 16254 39 resolution resolution NN cord-005453-4057qib7 16254 40 HLA HLA NNP cord-005453-4057qib7 16254 41 , , , cord-005453-4057qib7 16254 42 and and CC cord-005453-4057qib7 16254 43 therefore therefore RB cord-005453-4057qib7 16254 44 the the DT cord-005453-4057qib7 16254 45 involvement involvement NN cord-005453-4057qib7 16254 46 of of IN cord-005453-4057qib7 16254 47 social social JJ cord-005453-4057qib7 16254 48 security security NN cord-005453-4057qib7 16254 49 institutions institution NNS cord-005453-4057qib7 16254 50 and and CC cord-005453-4057qib7 16254 51 payment payment NN cord-005453-4057qib7 16254 52 procedures procedure NNS cord-005453-4057qib7 16254 53 were be VBD cord-005453-4057qib7 16254 54 among among IN cord-005453-4057qib7 16254 55 the the DT cord-005453-4057qib7 16254 56 factors factor NNS cord-005453-4057qib7 16254 57 extending extend VBG cord-005453-4057qib7 16254 58 this this DT cord-005453-4057qib7 16254 59 process process NN cord-005453-4057qib7 16254 60 . . . cord-005453-4057qib7 16255 1 Disclosure disclosure NN cord-005453-4057qib7 16255 2 : : : cord-005453-4057qib7 16255 3 Nothing nothing NN cord-005453-4057qib7 16255 4 to to TO cord-005453-4057qib7 16255 5 declare declare VB cord-005453-4057qib7 16255 6 Background background NN cord-005453-4057qib7 16255 7 : : : cord-005453-4057qib7 16255 8 Allogeneic allogeneic NN cord-005453-4057qib7 16255 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 16255 10 stem stem NN cord-005453-4057qib7 16255 11 cell cell NN cord-005453-4057qib7 16255 12 transplantation transplantation NN cord-005453-4057qib7 16255 13 ( ( -LRB- cord-005453-4057qib7 16255 14 AHSCT AHSCT NNP cord-005453-4057qib7 16255 15 ) ) -RRB- cord-005453-4057qib7 16255 16 is be VBZ cord-005453-4057qib7 16255 17 being be VBG cord-005453-4057qib7 16255 18 performed perform VBN cord-005453-4057qib7 16255 19 for for IN cord-005453-4057qib7 16255 20 a a DT cord-005453-4057qib7 16255 21 group group NN cord-005453-4057qib7 16255 22 of of IN cord-005453-4057qib7 16255 23 hematologic hematologic JJ cord-005453-4057qib7 16255 24 diseases disease NNS cord-005453-4057qib7 16255 25 with with IN cord-005453-4057qib7 16255 26 a a DT cord-005453-4057qib7 16255 27 curative curative JJ cord-005453-4057qib7 16255 28 intent intent NN cord-005453-4057qib7 16255 29 . . . cord-005453-4057qib7 16256 1 Outcomes outcome NNS cord-005453-4057qib7 16256 2 after after IN cord-005453-4057qib7 16256 3 AHSCT AHSCT NNP cord-005453-4057qib7 16256 4 are be VBP cord-005453-4057qib7 16256 5 influenced influence VBN cord-005453-4057qib7 16256 6 by by IN cord-005453-4057qib7 16256 7 the the DT cord-005453-4057qib7 16256 8 type type NN cord-005453-4057qib7 16256 9 of of IN cord-005453-4057qib7 16256 10 donor donor NN cord-005453-4057qib7 16256 11 used use VBN cord-005453-4057qib7 16256 12 . . . cord-005453-4057qib7 16257 1 Haploidentical haploidentical JJ cord-005453-4057qib7 16257 2 transplantation transplantation NN cord-005453-4057qib7 16257 3 is be VBZ cord-005453-4057qib7 16257 4 an an DT cord-005453-4057qib7 16257 5 emerging emerge VBG cord-005453-4057qib7 16257 6 option option NN cord-005453-4057qib7 16257 7 when when WRB cord-005453-4057qib7 16257 8 a a DT cord-005453-4057qib7 16257 9 fullmatched fullmatched JJ cord-005453-4057qib7 16257 10 donor donor NN cord-005453-4057qib7 16257 11 is be VBZ cord-005453-4057qib7 16257 12 unavailable unavailable JJ cord-005453-4057qib7 16257 13 . . . cord-005453-4057qib7 16258 1 Methods method NNS cord-005453-4057qib7 16258 2 : : : cord-005453-4057qib7 16258 3 We -PRON- PRP cord-005453-4057qib7 16258 4 retrospectively retrospectively RB cord-005453-4057qib7 16258 5 analyzed analyze VBD cord-005453-4057qib7 16258 6 our -PRON- PRP$ cord-005453-4057qib7 16258 7 transplants transplant NNS cord-005453-4057qib7 16258 8 performed perform VBN cord-005453-4057qib7 16258 9 between between IN cord-005453-4057qib7 16258 10 January January NNP cord-005453-4057qib7 16258 11 2015 2015 CD cord-005453-4057qib7 16258 12 and and CC cord-005453-4057qib7 16258 13 November November NNP cord-005453-4057qib7 16258 14 2018 2018 CD cord-005453-4057qib7 16258 15 , , , cord-005453-4057qib7 16258 16 investigating investigate VBG cord-005453-4057qib7 16258 17 outcomes outcome NNS cord-005453-4057qib7 16258 18 and and CC cord-005453-4057qib7 16258 19 complications complication NNS cord-005453-4057qib7 16258 20 among among IN cord-005453-4057qib7 16258 21 haploidentical haploidentical JJ cord-005453-4057qib7 16258 22 stem stem NN cord-005453-4057qib7 16258 23 cell cell NN cord-005453-4057qib7 16258 24 recipients recipient NNS cord-005453-4057qib7 16258 25 . . . cord-005453-4057qib7 16259 1 Results result NNS cord-005453-4057qib7 16259 2 : : : cord-005453-4057qib7 16260 1 One one CD cord-005453-4057qib7 16260 2 hundred hundred CD cord-005453-4057qib7 16260 3 and and CC cord-005453-4057qib7 16260 4 nineteen nineteen CD cord-005453-4057qib7 16260 5 patients patient NNS cord-005453-4057qib7 16260 6 underwent undergo VBD cord-005453-4057qib7 16260 7 AHSCT AHSCT NNP cord-005453-4057qib7 16260 8 , , , cord-005453-4057qib7 16260 9 9 9 CD cord-005453-4057qib7 16260 10 of of IN cord-005453-4057qib7 16260 11 them -PRON- PRP cord-005453-4057qib7 16260 12 ( ( -LRB- cord-005453-4057qib7 16260 13 7.5 7.5 CD cord-005453-4057qib7 16260 14 % % NN cord-005453-4057qib7 16260 15 ) ) -RRB- cord-005453-4057qib7 16260 16 were be VBD cord-005453-4057qib7 16260 17 recipient recipient NN cord-005453-4057qib7 16260 18 of of IN cord-005453-4057qib7 16260 19 a a DT cord-005453-4057qib7 16260 20 haploidentical haploidentical JJ cord-005453-4057qib7 16260 21 stem stem NN cord-005453-4057qib7 16260 22 cell cell NN cord-005453-4057qib7 16260 23 and and CC cord-005453-4057qib7 16260 24 included include VBN cord-005453-4057qib7 16260 25 in in IN cord-005453-4057qib7 16260 26 this this DT cord-005453-4057qib7 16260 27 study study NN cord-005453-4057qib7 16260 28 . . . cord-005453-4057qib7 16261 1 One one CD cord-005453-4057qib7 16261 2 patient patient NN cord-005453-4057qib7 16261 3 diagnosed diagnose VBN cord-005453-4057qib7 16261 4 with with IN cord-005453-4057qib7 16261 5 acute acute JJ cord-005453-4057qib7 16261 6 lymphoblastic lymphoblastic JJ cord-005453-4057qib7 16261 7 leukemia leukemia NN cord-005453-4057qib7 16261 8 ( ( -LRB- cord-005453-4057qib7 16261 9 ALL all DT cord-005453-4057qib7 16261 10 ) ) -RRB- cord-005453-4057qib7 16261 11 were be VBD cord-005453-4057qib7 16261 12 performed perform VBN cord-005453-4057qib7 16261 13 a a DT cord-005453-4057qib7 16261 14 haploidentical haploidentical JJ cord-005453-4057qib7 16261 15 AHSCT AHSCT NNP cord-005453-4057qib7 16261 16 for for IN cord-005453-4057qib7 16261 17 two two CD cord-005453-4057qib7 16261 18 times time NNS cord-005453-4057qib7 16261 19 due due JJ cord-005453-4057qib7 16261 20 to to IN cord-005453-4057qib7 16261 21 relapse relapse NN cord-005453-4057qib7 16261 22 . . . cord-005453-4057qib7 16262 1 Among among IN cord-005453-4057qib7 16262 2 those those DT cord-005453-4057qib7 16262 3 9 9 CD cord-005453-4057qib7 16262 4 transplants transplant NNS cord-005453-4057qib7 16262 5 , , , cord-005453-4057qib7 16262 6 4 4 CD cord-005453-4057qib7 16262 7 of of IN cord-005453-4057qib7 16262 8 them -PRON- PRP cord-005453-4057qib7 16262 9 were be VBD cord-005453-4057qib7 16262 10 diagnosed diagnose VBN cord-005453-4057qib7 16262 11 with with IN cord-005453-4057qib7 16262 12 acute acute JJ cord-005453-4057qib7 16262 13 myeloid myeloid NN cord-005453-4057qib7 16262 14 leukemia leukemia NN cord-005453-4057qib7 16262 15 , , , cord-005453-4057qib7 16262 16 2 2 CD cord-005453-4057qib7 16262 17 with with IN cord-005453-4057qib7 16262 18 ALL all DT cord-005453-4057qib7 16262 19 , , , cord-005453-4057qib7 16262 20 1 1 CD cord-005453-4057qib7 16262 21 with with IN cord-005453-4057qib7 16262 22 chronic chronic JJ cord-005453-4057qib7 16262 23 lymphocytic lymphocytic JJ cord-005453-4057qib7 16262 24 leukemia leukemia NN cord-005453-4057qib7 16262 25 , , , cord-005453-4057qib7 16262 26 1 1 CD cord-005453-4057qib7 16262 27 with with IN cord-005453-4057qib7 16262 28 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 16262 29 syndrome syndrome NN cord-005453-4057qib7 16262 30 and and CC cord-005453-4057qib7 16262 31 1 1 CD cord-005453-4057qib7 16262 32 with with IN cord-005453-4057qib7 16262 33 Hodgkin Hodgkin NNP cord-005453-4057qib7 16262 34 lymphoma lymphoma NN cord-005453-4057qib7 16262 35 . . . cord-005453-4057qib7 16263 1 The the DT cord-005453-4057qib7 16263 2 mean mean JJ cord-005453-4057qib7 16263 3 age age NN cord-005453-4057qib7 16263 4 of of IN cord-005453-4057qib7 16263 5 group group NN cord-005453-4057qib7 16263 6 was be VBD cord-005453-4057qib7 16263 7 35.7±15.2 35.7±15.2 CD cord-005453-4057qib7 16263 8 years year NNS cord-005453-4057qib7 16263 9 . . . cord-005453-4057qib7 16264 1 Three three CD cord-005453-4057qib7 16264 2 patients patient NNS cord-005453-4057qib7 16264 3 ( ( -LRB- cord-005453-4057qib7 16264 4 2 2 CD cord-005453-4057qib7 16264 5 AML AML NNP cord-005453-4057qib7 16264 6 , , , cord-005453-4057qib7 16264 7 1 1 CD cord-005453-4057qib7 16264 8 ALL all DT cord-005453-4057qib7 16264 9 ) ) -RRB- cord-005453-4057qib7 16264 10 were be VBD cord-005453-4057qib7 16264 11 in in IN cord-005453-4057qib7 16264 12 remission remission NN cord-005453-4057qib7 16264 13 at at IN cord-005453-4057qib7 16264 14 the the DT cord-005453-4057qib7 16264 15 time time NN cord-005453-4057qib7 16264 16 of of IN cord-005453-4057qib7 16264 17 transplantation transplantation NN cord-005453-4057qib7 16264 18 . . . cord-005453-4057qib7 16265 1 Patients patient NNS cord-005453-4057qib7 16265 2 were be VBD cord-005453-4057qib7 16265 3 given give VBN cord-005453-4057qib7 16265 4 a a DT cord-005453-4057qib7 16265 5 conditioning conditioning NN cord-005453-4057qib7 16265 6 regimen regimen NN cord-005453-4057qib7 16265 7 based base VBN cord-005453-4057qib7 16265 8 mostly mostly RB cord-005453-4057qib7 16265 9 on on IN cord-005453-4057qib7 16265 10 busulfan busulfan NN cord-005453-4057qib7 16265 11 , , , cord-005453-4057qib7 16265 12 fludarabin fludarabin JJ cord-005453-4057qib7 16265 13 and and CC cord-005453-4057qib7 16265 14 total total JJ cord-005453-4057qib7 16265 15 body body NN cord-005453-4057qib7 16265 16 irradiation irradiation NN cord-005453-4057qib7 16265 17 with with IN cord-005453-4057qib7 16265 18 a a DT cord-005453-4057qib7 16265 19 myeloablative myeloablative JJ cord-005453-4057qib7 16265 20 intent intent NN cord-005453-4057qib7 16265 21 . . . cord-005453-4057qib7 16266 1 Patients patient NNS cord-005453-4057qib7 16266 2 were be VBD cord-005453-4057qib7 16266 3 also also RB cord-005453-4057qib7 16266 4 given give VBN cord-005453-4057qib7 16266 5 a a DT cord-005453-4057qib7 16266 6 various various JJ cord-005453-4057qib7 16266 7 combinations combination NNS cord-005453-4057qib7 16266 8 of of IN cord-005453-4057qib7 16266 9 post post JJ cord-005453-4057qib7 16266 10 - - JJ cord-005453-4057qib7 16266 11 transplant transplant NN cord-005453-4057qib7 16266 12 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 16266 13 , , , cord-005453-4057qib7 16266 14 calcineurin calcineurin NNP cord-005453-4057qib7 16266 15 inhibitors inhibitor NNS cord-005453-4057qib7 16266 16 , , , cord-005453-4057qib7 16266 17 mycophenolate mycophenolate NNP cord-005453-4057qib7 16266 18 mofetil mofetil NNP cord-005453-4057qib7 16266 19 and and CC cord-005453-4057qib7 16266 20 antithymocyte antithymocyte NNP cord-005453-4057qib7 16266 21 globulin globulin NNP cord-005453-4057qib7 16266 22 for for IN cord-005453-4057qib7 16266 23 graft graft NN cord-005453-4057qib7 16266 24 versus versus IN cord-005453-4057qib7 16266 25 host host NN cord-005453-4057qib7 16266 26 disease disease NN cord-005453-4057qib7 16266 27 ( ( -LRB- cord-005453-4057qib7 16266 28 GVHD GVHD NNP cord-005453-4057qib7 16266 29 ) ) -RRB- cord-005453-4057qib7 16266 30 prophylaxis prophylaxis NN cord-005453-4057qib7 16266 31 ; ; : cord-005453-4057qib7 16266 32 post post JJ cord-005453-4057qib7 16266 33 - - JJ cord-005453-4057qib7 16266 34 transplant transplant NN cord-005453-4057qib7 16266 35 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 16266 36 administered administer VBN cord-005453-4057qib7 16266 37 on on IN cord-005453-4057qib7 16266 38 6 6 CD cord-005453-4057qib7 16266 39 ( ( -LRB- cord-005453-4057qib7 16266 40 67 67 CD cord-005453-4057qib7 16266 41 % % NN cord-005453-4057qib7 16266 42 ) ) -RRB- cord-005453-4057qib7 16266 43 of of IN cord-005453-4057qib7 16266 44 those those DT cord-005453-4057qib7 16266 45 transplantations transplantation NNS cord-005453-4057qib7 16266 46 . . . cord-005453-4057qib7 16267 1 Peripheral peripheral JJ cord-005453-4057qib7 16267 2 blood blood NN cord-005453-4057qib7 16267 3 was be VBD cord-005453-4057qib7 16267 4 the the DT cord-005453-4057qib7 16267 5 source source NN cord-005453-4057qib7 16267 6 of of IN cord-005453-4057qib7 16267 7 stem stem NN cord-005453-4057qib7 16267 8 cells cell NNS cord-005453-4057qib7 16267 9 in in IN cord-005453-4057qib7 16267 10 all all DT cord-005453-4057qib7 16267 11 patients patient NNS cord-005453-4057qib7 16267 12 . . . cord-005453-4057qib7 16268 1 Patients patient NNS cord-005453-4057qib7 16268 2 were be VBD cord-005453-4057qib7 16268 3 infused infuse VBN cord-005453-4057qib7 16268 4 with with IN cord-005453-4057qib7 16268 5 mean mean JJ cord-005453-4057qib7 16268 6 6.15±0.67x10 6.15±0.67x10 CD cord-005453-4057qib7 16268 7 6 6 CD cord-005453-4057qib7 16268 8 /kg /kg CD cord-005453-4057qib7 16268 9 of of IN cord-005453-4057qib7 16268 10 CD34 CD34 NNP cord-005453-4057qib7 16268 11 + + CC cord-005453-4057qib7 16268 12 cells cell NNS cord-005453-4057qib7 16268 13 . . . cord-005453-4057qib7 16269 1 Hematological Hematological NNP cord-005453-4057qib7 16269 2 recovery recovery NN cord-005453-4057qib7 16269 3 was be VBD cord-005453-4057qib7 16269 4 achieved achieve VBN cord-005453-4057qib7 16269 5 with with IN cord-005453-4057qib7 16269 6 neutrophil neutrophil NN cord-005453-4057qib7 16269 7 engraftment engraftment NN cord-005453-4057qib7 16269 8 at at IN cord-005453-4057qib7 16269 9 a a DT cord-005453-4057qib7 16269 10 mean mean NN cord-005453-4057qib7 16269 11 of of IN cord-005453-4057qib7 16269 12 19.2±2.1 19.2±2.1 CD cord-005453-4057qib7 16269 13 days day NNS cord-005453-4057qib7 16269 14 and and CC cord-005453-4057qib7 16269 15 platelet platelet NN cord-005453-4057qib7 16269 16 engraftment engraftment NN cord-005453-4057qib7 16269 17 at at IN cord-005453-4057qib7 16269 18 a a DT cord-005453-4057qib7 16269 19 mean mean NN cord-005453-4057qib7 16269 20 of of IN cord-005453-4057qib7 16269 21 17.3±2.7 17.3±2.7 CD cord-005453-4057qib7 16269 22 days day NNS cord-005453-4057qib7 16269 23 . . . cord-005453-4057qib7 16270 1 After after IN cord-005453-4057qib7 16270 2 a a DT cord-005453-4057qib7 16270 3 median median JJ cord-005453-4057qib7 16270 4 8month 8month JJ cord-005453-4057qib7 16270 5 ( ( -LRB- cord-005453-4057qib7 16270 6 0.2 0.2 CD cord-005453-4057qib7 16270 7 - - SYM cord-005453-4057qib7 16270 8 40.6 40.6 CD cord-005453-4057qib7 16270 9 months month NNS cord-005453-4057qib7 16270 10 ) ) -RRB- cord-005453-4057qib7 16270 11 follow follow VBP cord-005453-4057qib7 16270 12 up up RP cord-005453-4057qib7 16270 13 , , , cord-005453-4057qib7 16270 14 the the DT cord-005453-4057qib7 16270 15 cumulative cumulative JJ cord-005453-4057qib7 16270 16 rates rate NNS cord-005453-4057qib7 16270 17 of of IN cord-005453-4057qib7 16270 18 grade grade NN cord-005453-4057qib7 16270 19 3 3 CD cord-005453-4057qib7 16270 20 - - SYM cord-005453-4057qib7 16270 21 4 4 CD cord-005453-4057qib7 16270 22 GVHD GVHD NNP cord-005453-4057qib7 16270 23 , , , cord-005453-4057qib7 16270 24 relapse relapse NN cord-005453-4057qib7 16270 25 and and CC cord-005453-4057qib7 16270 26 non non JJ cord-005453-4057qib7 16270 27 - - JJ cord-005453-4057qib7 16270 28 relapse relapse JJ cord-005453-4057qib7 16270 29 mortality mortality NN cord-005453-4057qib7 16270 30 were be VBD cord-005453-4057qib7 16270 31 11 11 CD cord-005453-4057qib7 16270 32 % % NN cord-005453-4057qib7 16270 33 , , , cord-005453-4057qib7 16270 34 28 28 CD cord-005453-4057qib7 16270 35 % % NN cord-005453-4057qib7 16270 36 ( ( -LRB- cord-005453-4057qib7 16270 37 n=7 n=7 NN cord-005453-4057qib7 16270 38 ) ) -RRB- cord-005453-4057qib7 16270 39 and and CC cord-005453-4057qib7 16270 40 71 71 CD cord-005453-4057qib7 16270 41 % % NN cord-005453-4057qib7 16270 42 , , , cord-005453-4057qib7 16270 43 respectively respectively RB cord-005453-4057qib7 16270 44 . . . cord-005453-4057qib7 16271 1 One one CD cord-005453-4057qib7 16271 2 patient patient NN cord-005453-4057qib7 16271 3 died die VBD cord-005453-4057qib7 16271 4 due due IN cord-005453-4057qib7 16271 5 to to IN cord-005453-4057qib7 16271 6 relapse relapse NN cord-005453-4057qib7 16271 7 , , , cord-005453-4057qib7 16271 8 at at IN cord-005453-4057qib7 16271 9 the the DT cord-005453-4057qib7 16271 10 end end NN cord-005453-4057qib7 16271 11 of of IN cord-005453-4057qib7 16271 12 the the DT cord-005453-4057qib7 16271 13 follow follow NN cord-005453-4057qib7 16271 14 up up RP cord-005453-4057qib7 16271 15 two two CD cord-005453-4057qib7 16271 16 were be VBD cord-005453-4057qib7 16271 17 still still RB cord-005453-4057qib7 16271 18 alive alive JJ cord-005453-4057qib7 16271 19 with with IN cord-005453-4057qib7 16271 20 remission remission NN cord-005453-4057qib7 16271 21 . . . cord-005453-4057qib7 16272 1 Only only RB cord-005453-4057qib7 16272 2 one one CD cord-005453-4057qib7 16272 3 patient patient NN cord-005453-4057qib7 16272 4 has have VBZ cord-005453-4057qib7 16272 5 died die VBN cord-005453-4057qib7 16272 6 due due IN cord-005453-4057qib7 16272 7 to to IN cord-005453-4057qib7 16272 8 chronic chronic JJ cord-005453-4057qib7 16272 9 GVHD GVHD NNP cord-005453-4057qib7 16272 10 affecting affect VBG cord-005453-4057qib7 16272 11 serosa serosa NN cord-005453-4057qib7 16272 12 and and CC cord-005453-4057qib7 16272 13 resulting result VBG cord-005453-4057qib7 16272 14 with with IN cord-005453-4057qib7 16272 15 a a DT cord-005453-4057qib7 16272 16 fatal fatal JJ cord-005453-4057qib7 16272 17 tracheoesophageal tracheoesophageal JJ cord-005453-4057qib7 16272 18 fistula fistula NN cord-005453-4057qib7 16272 19 . . . cord-005453-4057qib7 16273 1 The the DT cord-005453-4057qib7 16273 2 mean mean JJ cord-005453-4057qib7 16273 3 overall overall JJ cord-005453-4057qib7 16273 4 survival survival NN cord-005453-4057qib7 16273 5 was be VBD cord-005453-4057qib7 16273 6 6.9±2.6 6.9±2.6 CD cord-005453-4057qib7 16273 7 months month NNS cord-005453-4057qib7 16273 8 in in IN cord-005453-4057qib7 16273 9 our -PRON- PRP$ cord-005453-4057qib7 16273 10 study study NN cord-005453-4057qib7 16273 11 . . . cord-005453-4057qib7 16274 1 Conclusions conclusion NNS cord-005453-4057qib7 16274 2 : : : cord-005453-4057qib7 16275 1 Haploidentical haploidentical JJ cord-005453-4057qib7 16275 2 transplant transplant NN cord-005453-4057qib7 16275 3 is be VBZ cord-005453-4057qib7 16275 4 a a DT cord-005453-4057qib7 16275 5 feasible feasible JJ cord-005453-4057qib7 16275 6 option option NN cord-005453-4057qib7 16275 7 in in IN cord-005453-4057qib7 16275 8 hematologic hematologic JJ cord-005453-4057qib7 16275 9 malignancies malignancy NNS cord-005453-4057qib7 16275 10 with with IN cord-005453-4057qib7 16275 11 novel novel JJ cord-005453-4057qib7 16275 12 GVHD GVHD NNP cord-005453-4057qib7 16275 13 prophylaxis prophylaxis NN cord-005453-4057qib7 16275 14 approaches approach NNS cord-005453-4057qib7 16275 15 , , , cord-005453-4057qib7 16275 16 especially especially RB cord-005453-4057qib7 16275 17 post post JJ cord-005453-4057qib7 16275 18 - - NN cord-005453-4057qib7 16275 19 transplantation transplantation JJ cord-005453-4057qib7 16275 20 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 16275 21 . . . cord-005453-4057qib7 16276 1 However however RB cord-005453-4057qib7 16276 2 , , , cord-005453-4057qib7 16276 3 these these DT cord-005453-4057qib7 16276 4 results result NNS cord-005453-4057qib7 16276 5 need need VBP cord-005453-4057qib7 16276 6 to to TO cord-005453-4057qib7 16276 7 be be VB cord-005453-4057qib7 16276 8 supported support VBN cord-005453-4057qib7 16276 9 with with IN cord-005453-4057qib7 16276 10 further further JJ cord-005453-4057qib7 16276 11 investigations investigation NNS cord-005453-4057qib7 16276 12 with with IN cord-005453-4057qib7 16276 13 a a DT cord-005453-4057qib7 16276 14 larger large JJR cord-005453-4057qib7 16276 15 patient patient NN cord-005453-4057qib7 16276 16 group group NN cord-005453-4057qib7 16276 17 . . . cord-005453-4057qib7 16277 1 Disclosure disclosure NN cord-005453-4057qib7 16277 2 : : : cord-005453-4057qib7 16277 3 Nothing nothing NN cord-005453-4057qib7 16277 4 to to TO cord-005453-4057qib7 16277 5 declare declare VB cord-005453-4057qib7 16277 6 Results result NNS cord-005453-4057qib7 16277 7 : : : cord-005453-4057qib7 16277 8 A a DT cord-005453-4057qib7 16277 9 total total NN cord-005453-4057qib7 16277 10 of of IN cord-005453-4057qib7 16277 11 25 25 CD cord-005453-4057qib7 16277 12 patients patient NNS cord-005453-4057qib7 16277 13 between between IN cord-005453-4057qib7 16277 14 19 19 CD cord-005453-4057qib7 16277 15 and and CC cord-005453-4057qib7 16277 16 58 58 CD cord-005453-4057qib7 16277 17 years year NNS cord-005453-4057qib7 16277 18 ( ( -LRB- cord-005453-4057qib7 16277 19 median median JJ cord-005453-4057qib7 16277 20 age age NN cord-005453-4057qib7 16277 21 : : : cord-005453-4057qib7 16277 22 33 33 CD cord-005453-4057qib7 16277 23 years year NNS cord-005453-4057qib7 16277 24 ) ) -RRB- cord-005453-4057qib7 16277 25 . . . cord-005453-4057qib7 16278 1 Transplant transplant NN cord-005453-4057qib7 16278 2 was be VBD cord-005453-4057qib7 16278 3 done do VBN cord-005453-4057qib7 16278 4 for for IN cord-005453-4057qib7 16278 5 following follow VBG cord-005453-4057qib7 16278 6 disease disease NN cord-005453-4057qib7 16278 7 : : : cord-005453-4057qib7 16278 8 acute acute JJ cord-005453-4057qib7 16278 9 leukemia leukemia NN cord-005453-4057qib7 16278 10 ( ( -LRB- cord-005453-4057qib7 16278 11 n=9 n=9 NN cord-005453-4057qib7 16278 12 , , , cord-005453-4057qib7 16278 13 36 36 CD cord-005453-4057qib7 16278 14 % % NN cord-005453-4057qib7 16278 15 ) ) -RRB- cord-005453-4057qib7 16278 16 , , , cord-005453-4057qib7 16278 17 aplastic aplastic JJ cord-005453-4057qib7 16278 18 anemia anemia NN cord-005453-4057qib7 16278 19 ( ( -LRB- cord-005453-4057qib7 16278 20 n=5 n=5 RB cord-005453-4057qib7 16278 21 , , , cord-005453-4057qib7 16278 22 20 20 CD cord-005453-4057qib7 16278 23 % % NN cord-005453-4057qib7 16278 24 ) ) -RRB- cord-005453-4057qib7 16278 25 , , , cord-005453-4057qib7 16278 26 lymphoma lymphoma NN cord-005453-4057qib7 16278 27 ( ( -LRB- cord-005453-4057qib7 16278 28 n=4 n=4 NNS cord-005453-4057qib7 16278 29 , , , cord-005453-4057qib7 16278 30 16 16 CD cord-005453-4057qib7 16278 31 % % NN cord-005453-4057qib7 16278 32 ) ) -RRB- cord-005453-4057qib7 16278 33 , , , cord-005453-4057qib7 16278 34 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 16278 35 ( ( -LRB- cord-005453-4057qib7 16278 36 n=3 n=3 NN cord-005453-4057qib7 16278 37 , , , cord-005453-4057qib7 16278 38 12 12 CD cord-005453-4057qib7 16278 39 % % NN cord-005453-4057qib7 16278 40 ) ) -RRB- cord-005453-4057qib7 16278 41 , , , cord-005453-4057qib7 16278 42 myelodisplastic myelodisplastic NNP cord-005453-4057qib7 16278 43 syndrome syndrome NN cord-005453-4057qib7 16278 44 ( ( -LRB- cord-005453-4057qib7 16278 45 n=2 n=2 NNS cord-005453-4057qib7 16278 46 , , , cord-005453-4057qib7 16278 47 8 8 CD cord-005453-4057qib7 16278 48 % % NN cord-005453-4057qib7 16278 49 ) ) -RRB- cord-005453-4057qib7 16278 50 , , , cord-005453-4057qib7 16278 51 chronic chronic JJ cord-005453-4057qib7 16278 52 myeloid myeloid NN cord-005453-4057qib7 16278 53 leukemia leukemia NN cord-005453-4057qib7 16278 54 ( ( -LRB- cord-005453-4057qib7 16278 55 n=2 n=2 NNS cord-005453-4057qib7 16278 56 , , , cord-005453-4057qib7 16278 57 8 8 CD cord-005453-4057qib7 16278 58 % % NN cord-005453-4057qib7 16278 59 ) ) -RRB- cord-005453-4057qib7 16278 60 . . . cord-005453-4057qib7 16279 1 Ten ten CD cord-005453-4057qib7 16279 2 donors donor NNS cord-005453-4057qib7 16279 3 were be VBD cord-005453-4057qib7 16279 4 from from IN cord-005453-4057qib7 16279 5 Turkey Turkey NNP cord-005453-4057qib7 16279 6 and and CC cord-005453-4057qib7 16279 7 fifteen fifteen CD cord-005453-4057qib7 16279 8 donors donor NNS cord-005453-4057qib7 16279 9 were be VBD cord-005453-4057qib7 16279 10 from from IN cord-005453-4057qib7 16279 11 different different JJ cord-005453-4057qib7 16279 12 countries country NNS cord-005453-4057qib7 16279 13 of of IN cord-005453-4057qib7 16279 14 Europe Europe NNP cord-005453-4057qib7 16279 15 and and CC cord-005453-4057qib7 16279 16 America America NNP cord-005453-4057qib7 16279 17 . . . cord-005453-4057qib7 16280 1 Two two CD cord-005453-4057qib7 16280 2 of of IN cord-005453-4057qib7 16280 3 25 25 CD cord-005453-4057qib7 16280 4 donors donor NNS cord-005453-4057qib7 16280 5 were be VBD cord-005453-4057qib7 16280 6 9/10 9/10 CD cord-005453-4057qib7 16280 7 and and CC cord-005453-4057qib7 16280 8 the the DT cord-005453-4057qib7 16280 9 other other JJ cord-005453-4057qib7 16280 10 23 23 CD cord-005453-4057qib7 16280 11 was be VBD cord-005453-4057qib7 16280 12 10/10 10/10 CD cord-005453-4057qib7 16280 13 HLA HLA NNP cord-005453-4057qib7 16280 14 matched match VBN cord-005453-4057qib7 16280 15 . . . cord-005453-4057qib7 16281 1 The the DT cord-005453-4057qib7 16281 2 conditioning conditioning NN cord-005453-4057qib7 16281 3 regimen regimen NN cord-005453-4057qib7 16281 4 was be VBD cord-005453-4057qib7 16281 5 mostly mostly RB cord-005453-4057qib7 16281 6 non non JJ cord-005453-4057qib7 16281 7 myeloablative myeloablative NNP cord-005453-4057qib7 16281 8 ( ( -LRB- cord-005453-4057qib7 16281 9 n=17 n=17 NNP cord-005453-4057qib7 16281 10 , , , cord-005453-4057qib7 16281 11 68 68 CD cord-005453-4057qib7 16281 12 % % NN cord-005453-4057qib7 16281 13 ) ) -RRB- cord-005453-4057qib7 16281 14 while while IN cord-005453-4057qib7 16281 15 eight eight CD cord-005453-4057qib7 16281 16 patients patient NNS cord-005453-4057qib7 16281 17 were be VBD cord-005453-4057qib7 16281 18 treated treat VBN cord-005453-4057qib7 16281 19 with with IN cord-005453-4057qib7 16281 20 myeloablative myeloablative JJ cord-005453-4057qib7 16281 21 regimen regimen NN cord-005453-4057qib7 16281 22 . . . cord-005453-4057qib7 16282 1 Other other JJ cord-005453-4057qib7 16282 2 than than IN cord-005453-4057qib7 16282 3 two two CD cord-005453-4057qib7 16282 4 patients patient NNS cord-005453-4057qib7 16282 5 who who WP cord-005453-4057qib7 16282 6 took take VBD cord-005453-4057qib7 16282 7 tacrolimus tacrolimus NNP cord-005453-4057qib7 16282 8 and and CC cord-005453-4057qib7 16282 9 mycophenolate mycophenolate NNP cord-005453-4057qib7 16282 10 mofetile mofetile NNP cord-005453-4057qib7 16282 11 all all DT cord-005453-4057qib7 16282 12 of of IN cord-005453-4057qib7 16282 13 them -PRON- PRP cord-005453-4057qib7 16282 14 got get VBD cord-005453-4057qib7 16282 15 cyclophosphamide cyclophosphamide RB cord-005453-4057qib7 16282 16 and and CC cord-005453-4057qib7 16282 17 methotrexate methotrexate NN cord-005453-4057qib7 16282 18 for for IN cord-005453-4057qib7 16282 19 graft graft NN cord-005453-4057qib7 16282 20 versus versus IN cord-005453-4057qib7 16282 21 host host NN cord-005453-4057qib7 16282 22 disease disease NN cord-005453-4057qib7 16282 23 ( ( -LRB- cord-005453-4057qib7 16282 24 GVHD GVHD NNP cord-005453-4057qib7 16282 25 ) ) -RRB- cord-005453-4057qib7 16282 26 prophylaxis prophylaxis NN cord-005453-4057qib7 16282 27 . . . cord-005453-4057qib7 16283 1 The the DT cord-005453-4057qib7 16283 2 median median JJ cord-005453-4057qib7 16283 3 time time NN cord-005453-4057qib7 16283 4 of of IN cord-005453-4057qib7 16283 5 neutrophil neutrophil NN cord-005453-4057qib7 16283 6 and and CC cord-005453-4057qib7 16283 7 platelets platelet NNS cord-005453-4057qib7 16283 8 engrafman engrafman NNP cord-005453-4057qib7 16283 9 were be VBD cord-005453-4057qib7 16283 10 18 18 CD cord-005453-4057qib7 16283 11 days day NNS cord-005453-4057qib7 16284 1 ( ( -LRB- cord-005453-4057qib7 16284 2 range range NNP cord-005453-4057qib7 16284 3 11 11 CD cord-005453-4057qib7 16284 4 - - SYM cord-005453-4057qib7 16284 5 31 31 CD cord-005453-4057qib7 16284 6 ) ) -RRB- cord-005453-4057qib7 16284 7 and and CC cord-005453-4057qib7 16284 8 13,5 13,5 CD cord-005453-4057qib7 16284 9 days day NNS cord-005453-4057qib7 16284 10 ( ( -LRB- cord-005453-4057qib7 16284 11 range range NNP cord-005453-4057qib7 16284 12 9 9 CD cord-005453-4057qib7 16284 13 - - SYM cord-005453-4057qib7 16284 14 36 36 CD cord-005453-4057qib7 16284 15 ) ) -RRB- cord-005453-4057qib7 16284 16 respectively respectively RB cord-005453-4057qib7 16284 17 . . . cord-005453-4057qib7 16285 1 Acute acute JJ cord-005453-4057qib7 16285 2 GVHD GVHD NNP cord-005453-4057qib7 16285 3 was be VBD cord-005453-4057qib7 16285 4 seen see VBN cord-005453-4057qib7 16285 5 nearly nearly RB cord-005453-4057qib7 16285 6 half half NN cord-005453-4057qib7 16285 7 of of IN cord-005453-4057qib7 16285 8 the the DT cord-005453-4057qib7 16285 9 patients patient NNS cord-005453-4057qib7 16285 10 ( ( -LRB- cord-005453-4057qib7 16285 11 47,8%).Overall 47,8%).overall CD cord-005453-4057qib7 16285 12 survival survival NN cord-005453-4057qib7 16285 13 was be VBD cord-005453-4057qib7 16285 14 40 40 CD cord-005453-4057qib7 16285 15 % % NN cord-005453-4057qib7 16285 16 for for IN cord-005453-4057qib7 16285 17 all all DT cord-005453-4057qib7 16285 18 patients patient NNS cord-005453-4057qib7 16285 19 and and CC cord-005453-4057qib7 16285 20 15 15 CD cord-005453-4057qib7 16285 21 of of IN cord-005453-4057qib7 16285 22 25 25 CD cord-005453-4057qib7 16285 23 patiens patien NNS cord-005453-4057qib7 16285 24 ( ( -LRB- cord-005453-4057qib7 16285 25 60 60 CD cord-005453-4057qib7 16285 26 % % NN cord-005453-4057qib7 16285 27 ) ) -RRB- cord-005453-4057qib7 16285 28 died die VBD cord-005453-4057qib7 16285 29 within within IN cord-005453-4057qib7 16285 30 first first JJ cord-005453-4057qib7 16285 31 month month NN cord-005453-4057qib7 16285 32 to to IN cord-005453-4057qib7 16285 33 18 18 CD cord-005453-4057qib7 16285 34 months month NNS cord-005453-4057qib7 16285 35 ( ( -LRB- cord-005453-4057qib7 16285 36 median median JJ cord-005453-4057qib7 16285 37 3 3 CD cord-005453-4057qib7 16285 38 months month NNS cord-005453-4057qib7 16285 39 ) ) -RRB- cord-005453-4057qib7 16285 40 . . . cord-005453-4057qib7 16286 1 The the DT cord-005453-4057qib7 16286 2 mortality mortality NN cord-005453-4057qib7 16286 3 rate rate NN cord-005453-4057qib7 16286 4 was be VBD cord-005453-4057qib7 16286 5 more more RBR cord-005453-4057qib7 16286 6 higher high JJR cord-005453-4057qib7 16286 7 for for IN cord-005453-4057qib7 16286 8 the the DT cord-005453-4057qib7 16286 9 recipients recipient NNS cord-005453-4057qib7 16286 10 who who WP cord-005453-4057qib7 16286 11 had have VBD cord-005453-4057qib7 16286 12 donor donor NN cord-005453-4057qib7 16286 13 source source NN cord-005453-4057qib7 16286 14 from from IN cord-005453-4057qib7 16286 15 countries country NNS cord-005453-4057qib7 16286 16 other other JJ cord-005453-4057qib7 16286 17 than than IN cord-005453-4057qib7 16286 18 Turkey Turkey NNP cord-005453-4057qib7 16286 19 ( ( -LRB- cord-005453-4057qib7 16286 20 30 30 CD cord-005453-4057qib7 16286 21 % % NN cord-005453-4057qib7 16286 22 vs vs IN cord-005453-4057qib7 16286 23 80 80 CD cord-005453-4057qib7 16286 24 % % NN cord-005453-4057qib7 16286 25 p=0,018 p=0,018 NN cord-005453-4057qib7 16286 26 ) ) -RRB- cord-005453-4057qib7 16286 27 . . . cord-005453-4057qib7 16287 1 Transplant transplant NN cord-005453-4057qib7 16287 2 related relate VBN cord-005453-4057qib7 16287 3 mortality mortality NN cord-005453-4057qib7 16287 4 was be VBD cord-005453-4057qib7 16287 5 the the DT cord-005453-4057qib7 16287 6 most most RBS cord-005453-4057qib7 16287 7 common common JJ cord-005453-4057qib7 16287 8 reason reason NN cord-005453-4057qib7 16287 9 of of IN cord-005453-4057qib7 16287 10 mortality mortality NN cord-005453-4057qib7 16287 11 ( ( -LRB- cord-005453-4057qib7 16287 12 n=7/ n=7/ NNP cord-005453-4057qib7 16287 13 15 15 CD cord-005453-4057qib7 16287 14 , , , cord-005453-4057qib7 16287 15 46,7 46,7 CD cord-005453-4057qib7 16287 16 % % NN cord-005453-4057qib7 16287 17 ) ) -RRB- cord-005453-4057qib7 16287 18 and and CC cord-005453-4057qib7 16287 19 other other JJ cord-005453-4057qib7 16287 20 reasons reason NNS cord-005453-4057qib7 16287 21 were be VBD cord-005453-4057qib7 16287 22 GVHD GVHD NNP cord-005453-4057qib7 16287 23 ( ( -LRB- cord-005453-4057qib7 16287 24 33,3 33,3 CD cord-005453-4057qib7 16287 25 % % NN cord-005453-4057qib7 16287 26 ) ) -RRB- cord-005453-4057qib7 16287 27 , , , cord-005453-4057qib7 16287 28 infections infection NNS cord-005453-4057qib7 16287 29 and and CC cord-005453-4057qib7 16287 30 cirrhosis cirrhosis NN cord-005453-4057qib7 16287 31 respectively respectively RB cord-005453-4057qib7 16287 32 . . . cord-005453-4057qib7 16288 1 Conclusions conclusion NNS cord-005453-4057qib7 16288 2 : : : cord-005453-4057qib7 16289 1 We -PRON- PRP cord-005453-4057qib7 16289 2 found find VBD cord-005453-4057qib7 16289 3 the the DT cord-005453-4057qib7 16289 4 mortality mortality NN cord-005453-4057qib7 16289 5 rate rate NN cord-005453-4057qib7 16289 6 more more RBR cord-005453-4057qib7 16289 7 higher high JJR cord-005453-4057qib7 16289 8 in in IN cord-005453-4057qib7 16289 9 the the DT cord-005453-4057qib7 16289 10 patients patient NNS cord-005453-4057qib7 16289 11 whose whose WP$ cord-005453-4057qib7 16289 12 donors donor NNS cord-005453-4057qib7 16289 13 were be VBD cord-005453-4057qib7 16289 14 from from IN cord-005453-4057qib7 16289 15 out out IN cord-005453-4057qib7 16289 16 of of IN cord-005453-4057qib7 16289 17 our -PRON- PRP$ cord-005453-4057qib7 16289 18 country country NN cord-005453-4057qib7 16289 19 . . . cord-005453-4057qib7 16290 1 However however RB cord-005453-4057qib7 16290 2 , , , cord-005453-4057qib7 16290 3 we -PRON- PRP cord-005453-4057qib7 16290 4 need need VBP cord-005453-4057qib7 16290 5 to to TO cord-005453-4057qib7 16290 6 further further JJ cord-005453-4057qib7 16290 7 multicentric multicentric JJ cord-005453-4057qib7 16290 8 and and CC cord-005453-4057qib7 16290 9 prospective prospective JJ cord-005453-4057qib7 16290 10 investigations investigation NNS cord-005453-4057qib7 16290 11 to to TO cord-005453-4057qib7 16290 12 confirm confirm VB cord-005453-4057qib7 16290 13 our -PRON- PRP$ cord-005453-4057qib7 16290 14 hypothesis hypothesis NN cord-005453-4057qib7 16290 15 , , , cord-005453-4057qib7 16290 16 it -PRON- PRP cord-005453-4057qib7 16290 17 would would MD cord-005453-4057qib7 16290 18 be be VB cord-005453-4057qib7 16290 19 related relate VBN cord-005453-4057qib7 16290 20 with with IN cord-005453-4057qib7 16290 21 impact impact NN cord-005453-4057qib7 16290 22 of of IN cord-005453-4057qib7 16290 23 ethnicity ethnicity NN cord-005453-4057qib7 16290 24 . . . cord-005453-4057qib7 16291 1 Disclosure disclosure NN cord-005453-4057qib7 16291 2 : : : cord-005453-4057qib7 16291 3 Nothing nothing NN cord-005453-4057qib7 16291 4 to to TO cord-005453-4057qib7 16291 5 disclose disclose VB cord-005453-4057qib7 16291 6 Late late RB cord-005453-4057qib7 16291 7 - - HYPH cord-005453-4057qib7 16291 8 breaking break VBG cord-005453-4057qib7 16291 9 abstracts abstract NNS cord-005453-4057qib7 16291 10 P725 P725 NNP cord-005453-4057qib7 16291 11 targeted target VBD cord-005453-4057qib7 16291 12 twice twice JJ cord-005453-4057qib7 16291 13 daily daily JJ cord-005453-4057qib7 16291 14 busulfan busulfan NN cord-005453-4057qib7 16291 15 - - HYPH cord-005453-4057qib7 16291 16 based base VBN cord-005453-4057qib7 16291 17 ric ric NN cord-005453-4057qib7 16291 18 - - HYPH cord-005453-4057qib7 16291 19 conditioning conditioning NN cord-005453-4057qib7 16291 20 for for IN cord-005453-4057qib7 16291 21 allogeneic allogeneic JJ cord-005453-4057qib7 16291 22 hematopoietic hematopoietic JJ cord-005453-4057qib7 16291 23 stem stem NN cord-005453-4057qib7 16291 24 cell cell NN cord-005453-4057qib7 16291 25 transplantation transplantation NN cord-005453-4057qib7 16291 26 in in IN cord-005453-4057qib7 16291 27 pediatric pediatric JJ cord-005453-4057qib7 16291 28 patients patient NNS cord-005453-4057qib7 16291 29 with with IN cord-005453-4057qib7 16291 30 chronic chronic JJ cord-005453-4057qib7 16291 31 granulomatous granulomatous JJ cord-005453-4057qib7 16291 32 disease disease NN cord-005453-4057qib7 16291 33 : : : cord-005453-4057qib7 16292 1 A a DT cord-005453-4057qib7 16292 2 10-year 10-year CD cord-005453-4057qib7 16292 3 experience experience NN cord-005453-4057qib7 16292 4 with with IN cord-005453-4057qib7 16292 5 the the DT cord-005453-4057qib7 16292 6 Zurich Zurich NNP cord-005453-4057qib7 16292 7 protocol protocol NN cord-005453-4057qib7 16292 8 Matthias Matthias NNP cord-005453-4057qib7 16292 9 Felber Felber NNP cord-005453-4057qib7 16292 10 1 1 CD cord-005453-4057qib7 16292 11 , , , cord-005453-4057qib7 16292 12 Mathias Mathias NNP cord-005453-4057qib7 16292 13 Hauri Hauri NNP cord-005453-4057qib7 16292 14 - - HYPH cord-005453-4057qib7 16292 15 Hohl Hohl NNP cord-005453-4057qib7 16292 16 1 1 CD cord-005453-4057qib7 16292 17 , , , cord-005453-4057qib7 16292 18 Ulrike Ulrike NNP cord-005453-4057qib7 16292 19 Zeilhofer Zeilhofer NNP cord-005453-4057qib7 16292 20 1 1 CD cord-005453-4057qib7 16292 21 , , , cord-005453-4057qib7 16292 22 Federica Federica NNP cord-005453-4057qib7 16292 23 Achini Achini NNP cord-005453-4057qib7 16292 24 1 1 CD cord-005453-4057qib7 16292 25 , , , cord-005453-4057qib7 16292 26 Jana Jana NNP cord-005453-4057qib7 16292 27 Pachlopnik Pachlopnik NNP cord-005453-4057qib7 16292 28 - - HYPH cord-005453-4057qib7 16292 29 Schmid Schmid NNP cord-005453-4057qib7 16292 30 2 2 CD cord-005453-4057qib7 16292 31 , , , cord-005453-4057qib7 16292 32 Janine Janine NNP cord-005453-4057qib7 16292 33 Reichenbach Reichenbach NNP cord-005453-4057qib7 16292 34 2 2 CD cord-005453-4057qib7 16292 35 , , , cord-005453-4057qib7 16292 36 Seraina Seraina NNP cord-005453-4057qib7 16292 37 Prader Prader NNP cord-005453-4057qib7 16292 38 2 2 CD cord-005453-4057qib7 16292 39 , , , cord-005453-4057qib7 16292 40 Tayfun Tayfun NNP cord-005453-4057qib7 16292 41 Güngör Güngör NNP cord-005453-4057qib7 16292 42 1Background 1background CD cord-005453-4057qib7 16292 43 : : : cord-005453-4057qib7 16292 44 Chronic chronic JJ cord-005453-4057qib7 16292 45 granulomatous granulomatous JJ cord-005453-4057qib7 16292 46 disease disease NN cord-005453-4057qib7 16292 47 ( ( -LRB- cord-005453-4057qib7 16292 48 CGD CGD NNP cord-005453-4057qib7 16292 49 ) ) -RRB- cord-005453-4057qib7 16292 50 needs need VBZ cord-005453-4057qib7 16292 51 sufficient sufficient JJ cord-005453-4057qib7 16292 52 myeloablation myeloablation NN cord-005453-4057qib7 16292 53 to to TO cord-005453-4057qib7 16292 54 avoid avoid VB cord-005453-4057qib7 16292 55 graft graft NN cord-005453-4057qib7 16292 56 failure failure NN cord-005453-4057qib7 16292 57 . . . cord-005453-4057qib7 16293 1 For for IN cord-005453-4057qib7 16293 2 this this DT cord-005453-4057qib7 16293 3 purpose purpose NN cord-005453-4057qib7 16293 4 the the DT cord-005453-4057qib7 16293 5 EBMT EBMT NNP cord-005453-4057qib7 16293 6 Inborn inborn JJ cord-005453-4057qib7 16293 7 errors error NNS cord-005453-4057qib7 16293 8 working work VBG cord-005453-4057qib7 16293 9 Party Party NNP cord-005453-4057qib7 16293 10 currently currently RB cord-005453-4057qib7 16293 11 recommends recommend VBZ cord-005453-4057qib7 16293 12 Treosulfan Treosulfan NNP cord-005453-4057qib7 16293 13 or or CC cord-005453-4057qib7 16293 14 Busulfan Busulfan NNP cord-005453-4057qib7 16293 15 - - HYPH cord-005453-4057qib7 16293 16 based base VBN cord-005453-4057qib7 16293 17 conditioning conditioning NN cord-005453-4057qib7 16293 18 regimens regimen NNS cord-005453-4057qib7 16293 19 for for IN cord-005453-4057qib7 16293 20 CGD CGD NNP cord-005453-4057qib7 16293 21 - - HYPH cord-005453-4057qib7 16293 22 SCT SCT NNP cord-005453-4057qib7 16293 23 . . . cord-005453-4057qib7 16294 1 We -PRON- PRP cord-005453-4057qib7 16294 2 analyzed analyze VBD cord-005453-4057qib7 16294 3 the the DT cord-005453-4057qib7 16294 4 last last JJ cord-005453-4057qib7 16294 5 10 10 CD cord-005453-4057qib7 16294 6 years year NNS cord-005453-4057qib7 16294 7 of of IN cord-005453-4057qib7 16294 8 targeted target VBN cord-005453-4057qib7 16294 9 Busulfan Busulfan NNP cord-005453-4057qib7 16294 10 - - HYPH cord-005453-4057qib7 16294 11 based base VBN cord-005453-4057qib7 16294 12 RIC RIC NNP cord-005453-4057qib7 16294 13 - - HYPH cord-005453-4057qib7 16294 14 conditioning conditioning NN cord-005453-4057qib7 16294 15 including include VBG cord-005453-4057qib7 16294 16 engraftment engraftment NN cord-005453-4057qib7 16294 17 , , , cord-005453-4057qib7 16294 18 GvHD GvHD NNP cord-005453-4057qib7 16294 19 rates rate NNS cord-005453-4057qib7 16294 20 , , , cord-005453-4057qib7 16294 21 chimerism chimerism NN cord-005453-4057qib7 16294 22 and and CC cord-005453-4057qib7 16294 23 late late JJ cord-005453-4057qib7 16294 24 term term NN cord-005453-4057qib7 16294 25 effects effect NNS cord-005453-4057qib7 16294 26 in in IN cord-005453-4057qib7 16294 27 our -PRON- PRP$ cord-005453-4057qib7 16294 28 pediatric pediatric JJ cord-005453-4057qib7 16294 29 SCT SCT NNP cord-005453-4057qib7 16294 30 center center NN cord-005453-4057qib7 16294 31 in in IN cord-005453-4057qib7 16294 32 Zurich Zurich NNP cord-005453-4057qib7 16294 33 . . . cord-005453-4057qib7 16295 1 Methods method NNS cord-005453-4057qib7 16295 2 : : : cord-005453-4057qib7 16296 1 Between between IN cord-005453-4057qib7 16296 2 2008 2008 CD cord-005453-4057qib7 16296 3 and and CC cord-005453-4057qib7 16296 4 2018 2018 CD cord-005453-4057qib7 16296 5 , , , cord-005453-4057qib7 16296 6 n=34 n=34 NNP cord-005453-4057qib7 16296 7 consecutive consecutive JJ cord-005453-4057qib7 16296 8 pediatric pediatric JJ cord-005453-4057qib7 16296 9 CGD CGD NNP cord-005453-4057qib7 16296 10 patients patient NNS cord-005453-4057qib7 16296 11 ( ( -LRB- cord-005453-4057qib7 16296 12 median median JJ cord-005453-4057qib7 16296 13 age age NN cord-005453-4057qib7 16296 14 6 6 CD cord-005453-4057qib7 16296 15 years year NNS cord-005453-4057qib7 16296 16 , , , cord-005453-4057qib7 16296 17 range range VBP cord-005453-4057qib7 16296 18 1 1 CD cord-005453-4057qib7 16296 19 - - SYM cord-005453-4057qib7 16296 20 16 16 CD cord-005453-4057qib7 16296 21 years year NNS cord-005453-4057qib7 16296 22 , , , cord-005453-4057qib7 16296 23 n=4 n=4 JJ cord-005453-4057qib7 16296 24 female female NN cord-005453-4057qib7 16296 25 , , , cord-005453-4057qib7 16296 26 n=9 n=9 JJ cord-005453-4057qib7 16296 27 autosomal autosomal JJ cord-005453-4057qib7 16296 28 recessive recessive JJ cord-005453-4057qib7 16296 29 inheritance inheritance NN cord-005453-4057qib7 16296 30 ) ) -RRB- cord-005453-4057qib7 16296 31 have have VBP cord-005453-4057qib7 16296 32 been be VBN cord-005453-4057qib7 16296 33 transplanted transplant VBN cord-005453-4057qib7 16296 34 . . . cord-005453-4057qib7 16297 1 All all DT cord-005453-4057qib7 16297 2 patients patient NNS cord-005453-4057qib7 16297 3 received receive VBD cord-005453-4057qib7 16297 4 therapeutic therapeutic JJ cord-005453-4057qib7 16297 5 drug drug NN cord-005453-4057qib7 16297 6 monitoring monitoring NN cord-005453-4057qib7 16297 7 of of IN cord-005453-4057qib7 16297 8 twice twice RB cord-005453-4057qib7 16297 9 daily daily RB cord-005453-4057qib7 16297 10 administered administer VBN cord-005453-4057qib7 16297 11 iv iv CD cord-005453-4057qib7 16297 12 Busulfan Busulfan NNP cord-005453-4057qib7 16297 13 ( ( -LRB- cord-005453-4057qib7 16297 14 3 3 CD cord-005453-4057qib7 16297 15 or or CC cord-005453-4057qib7 16297 16 4 4 CD cord-005453-4057qib7 16297 17 hour hour NN cord-005453-4057qib7 16297 18 infusions infusion NNS cord-005453-4057qib7 16297 19 ; ; : cord-005453-4057qib7 16297 20 d-5 d-5 ADD cord-005453-4057qib7 16297 21 to to IN cord-005453-4057qib7 16297 22 -d2 -d2 NN cord-005453-4057qib7 16297 23 ) ) -RRB- cord-005453-4057qib7 16297 24 to to TO cord-005453-4057qib7 16297 25 achieve achieve VB cord-005453-4057qib7 16297 26 a a DT cord-005453-4057qib7 16297 27 targeted target VBN cord-005453-4057qib7 16297 28 cumulative cumulative JJ cord-005453-4057qib7 16297 29 AUC auc NN cord-005453-4057qib7 16297 30 of of IN cord-005453-4057qib7 16297 31 45 45 CD cord-005453-4057qib7 16297 32 - - SYM cord-005453-4057qib7 16297 33 70 70 CD cord-005453-4057qib7 16297 34 mg mg NNP cord-005453-4057qib7 16297 35 / / SYM cord-005453-4057qib7 16297 36 L*h l*h NN cord-005453-4057qib7 16297 37 . . . cord-005453-4057qib7 16298 1 Fludarabine Fludarabine NNP cord-005453-4057qib7 16298 2 ( ( -LRB- cord-005453-4057qib7 16298 3 180 180 CD cord-005453-4057qib7 16298 4 mg/ mg/ NN cord-005453-4057qib7 16298 5 sqm sqm NN cord-005453-4057qib7 16298 6 ; ; : cord-005453-4057qib7 16298 7 d-8 d-8 NNP cord-005453-4057qib7 16298 8 to to IN cord-005453-4057qib7 16298 9 -d3 -d3 ADD cord-005453-4057qib7 16298 10 ) ) -RRB- cord-005453-4057qib7 16298 11 and and CC cord-005453-4057qib7 16298 12 serotherapy serotherapy NNP cord-005453-4057qib7 16299 1 ( ( -LRB- cord-005453-4057qib7 16299 2 Thymoglobuline Thymoglobuline NNP cord-005453-4057qib7 16299 3 7.5 7.5 CD cord-005453-4057qib7 16299 4 mg/ mg/ NN cord-005453-4057qib7 16299 5 kg kg NNP cord-005453-4057qib7 16299 6 total total NN cord-005453-4057qib7 16299 7 , , , cord-005453-4057qib7 16299 8 d-5 d-5 NN cord-005453-4057qib7 16299 9 to to IN cord-005453-4057qib7 16299 10 d-3 d-3 NNP cord-005453-4057qib7 16299 11 ) ) -RRB- cord-005453-4057qib7 16299 12 or or CC cord-005453-4057qib7 16299 13 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 16299 14 ( ( -LRB- cord-005453-4057qib7 16299 15 0.5 0.5 CD cord-005453-4057qib7 16299 16 - - SYM cord-005453-4057qib7 16299 17 0.6 0.6 CD cord-005453-4057qib7 16299 18 mg mg NNP cord-005453-4057qib7 16299 19 / / SYM cord-005453-4057qib7 16299 20 kg kg NNP cord-005453-4057qib7 16299 21 total total NN cord-005453-4057qib7 16299 22 ; ; : cord-005453-4057qib7 16299 23 d-8-to d-8-to NNP cord-005453-4057qib7 16299 24 d-6 d-6 NNP cord-005453-4057qib7 16299 25 ) ) -RRB- cord-005453-4057qib7 16299 26 were be VBD cord-005453-4057qib7 16299 27 used use VBN cord-005453-4057qib7 16299 28 for for IN cord-005453-4057qib7 16299 29 immunoablation immunoablation NN cord-005453-4057qib7 16299 30 . . . cord-005453-4057qib7 16300 1 Donors donor NNS cord-005453-4057qib7 16300 2 were be VBD cord-005453-4057qib7 16300 3 matched match VBN cord-005453-4057qib7 16300 4 unrelated unrelated JJ cord-005453-4057qib7 16300 5 ( ( -LRB- cord-005453-4057qib7 16300 6 10/10 10/10 CD cord-005453-4057qib7 16300 7 HLA HLA NNP cord-005453-4057qib7 16300 8 ; ; : cord-005453-4057qib7 16300 9 n= n= NNP cord-005453-4057qib7 16300 10 19 19 CD cord-005453-4057qib7 16300 11 ) ) -RRB- cord-005453-4057qib7 16300 12 , , , cord-005453-4057qib7 16300 13 mismatched mismatch VBN cord-005453-4057qib7 16300 14 unrelated unrelated JJ cord-005453-4057qib7 16300 15 ( ( -LRB- cord-005453-4057qib7 16300 16 9/10 9/10 CD cord-005453-4057qib7 16300 17 HLA HLA NNP cord-005453-4057qib7 16300 18 ; ; : cord-005453-4057qib7 16300 19 n= n= NNP cord-005453-4057qib7 16300 20 7 7 CD cord-005453-4057qib7 16300 21 ) ) -RRB- cord-005453-4057qib7 16300 22 , , , cord-005453-4057qib7 16300 23 mismatched mismatch VBN cord-005453-4057qib7 16300 24 unrelated unrelated JJ cord-005453-4057qib7 16300 25 ( ( -LRB- cord-005453-4057qib7 16300 26 HLA HLA NNP cord-005453-4057qib7 16300 27 8/10 8/10 CD cord-005453-4057qib7 16300 28 ; ; : cord-005453-4057qib7 16300 29 n=1 n=1 CD cord-005453-4057qib7 16300 30 ) ) -RRB- cord-005453-4057qib7 16300 31 , , , cord-005453-4057qib7 16300 32 matched match VBN cord-005453-4057qib7 16300 33 sibling sibling NN cord-005453-4057qib7 16300 34 ( ( -LRB- cord-005453-4057qib7 16300 35 HLA HLA NNP cord-005453-4057qib7 16300 36 6/6 6/6 CD cord-005453-4057qib7 16300 37 ; ; : cord-005453-4057qib7 16300 38 n= n= NNP cord-005453-4057qib7 16300 39 5 5 CD cord-005453-4057qib7 16300 40 ) ) -RRB- cord-005453-4057qib7 16300 41 and and CC cord-005453-4057qib7 16300 42 haploidentical haploidentical JJ cord-005453-4057qib7 16300 43 parental parental NN cord-005453-4057qib7 16300 44 ( ( -LRB- cord-005453-4057qib7 16300 45 HLA HLA NNP cord-005453-4057qib7 16300 46 5/10 5/10 CD cord-005453-4057qib7 16300 47 ; ; : cord-005453-4057qib7 16300 48 n=2 n=2 NNS cord-005453-4057qib7 16300 49 ) ) -RRB- cord-005453-4057qib7 16300 50 . . . cord-005453-4057qib7 16301 1 For for IN cord-005453-4057qib7 16301 2 2 2 CD cord-005453-4057qib7 16301 3 patients patient NNS cord-005453-4057qib7 16301 4 with with IN cord-005453-4057qib7 16301 5 haploidentical haploidentical JJ cord-005453-4057qib7 16301 6 donor donor NN cord-005453-4057qib7 16301 7 post post NN cord-005453-4057qib7 16301 8 - - JJ cord-005453-4057qib7 16301 9 transplant transplant NN cord-005453-4057qib7 16301 10 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 16301 11 ( ( -LRB- cord-005453-4057qib7 16301 12 d-3 d-3 NN cord-005453-4057qib7 16301 13 and and CC cord-005453-4057qib7 16301 14 d-4 d-4 NN cord-005453-4057qib7 16301 15 with with IN cord-005453-4057qib7 16301 16 50 50 CD cord-005453-4057qib7 16301 17 mg mg NNP cord-005453-4057qib7 16301 18 / / SYM cord-005453-4057qib7 16301 19 kg kg NNP cord-005453-4057qib7 16301 20 iv iv CD cord-005453-4057qib7 16301 21 each each DT cord-005453-4057qib7 16301 22 ) ) -RRB- cord-005453-4057qib7 16301 23 and and CC cord-005453-4057qib7 16301 24 upfront upfront JJ cord-005453-4057qib7 16301 25 ATG ATG NNP cord-005453-4057qib7 16301 26 - - HYPH cord-005453-4057qib7 16301 27 Grafalon Grafalon NNP cord-005453-4057qib7 16301 28 ( ( -LRB- cord-005453-4057qib7 16301 29 40 40 CD cord-005453-4057qib7 16301 30 mg mg NNP cord-005453-4057qib7 16301 31 / / SYM cord-005453-4057qib7 16301 32 kg kg NNP cord-005453-4057qib7 16301 33 -12 -12 NN cord-005453-4057qib7 16301 34 to to IN cord-005453-4057qib7 16301 35 - - HYPH cord-005453-4057qib7 16301 36 d-9 d-9 NN cord-005453-4057qib7 16301 37 ) ) -RRB- cord-005453-4057qib7 16301 38 was be VBD cord-005453-4057qib7 16301 39 used use VBN cord-005453-4057qib7 16301 40 . . . cord-005453-4057qib7 16302 1 Stem stem JJ cord-005453-4057qib7 16302 2 cell cell NN cord-005453-4057qib7 16302 3 sources source NNS cord-005453-4057qib7 16302 4 were be VBD cord-005453-4057qib7 16302 5 BM BM NNP cord-005453-4057qib7 16302 6 ( ( -LRB- cord-005453-4057qib7 16302 7 n=29 n=29 NNP cord-005453-4057qib7 16302 8 ) ) -RRB- cord-005453-4057qib7 16302 9 and and CC cord-005453-4057qib7 16302 10 PBSC PBSC NNP cord-005453-4057qib7 16302 11 ( ( -LRB- cord-005453-4057qib7 16302 12 n=5 n=5 RB cord-005453-4057qib7 16302 13 ) ) -RRB- cord-005453-4057qib7 16302 14 . . . cord-005453-4057qib7 16303 1 GVHDprophylaxis GVHDprophylaxis NNP cord-005453-4057qib7 16303 2 included include VBD cord-005453-4057qib7 16303 3 iv iv NNP cord-005453-4057qib7 16303 4 CSA CSA NNP cord-005453-4057qib7 16303 5 ( ( -LRB- cord-005453-4057qib7 16303 6 d-3 d-3 NNP cord-005453-4057qib7 16303 7 ; ; , cord-005453-4057qib7 16303 8 continuous continuous JJ cord-005453-4057qib7 16303 9 infusion infusion NN cord-005453-4057qib7 16303 10 ) ) -RRB- cord-005453-4057qib7 16303 11 and and CC cord-005453-4057qib7 16303 12 iv iv LS cord-005453-4057qib7 16303 13 . . . cord-005453-4057qib7 16303 14 MMF MMF NNP cord-005453-4057qib7 16303 15 ( ( -LRB- cord-005453-4057qib7 16303 16 d-0 d-0 NNP cord-005453-4057qib7 16303 17 , , , cord-005453-4057qib7 16303 18 in in IN cord-005453-4057qib7 16303 19 2 2 CD cord-005453-4057qib7 16303 20 - - SYM cord-005453-4057qib7 16303 21 3 3 CD cord-005453-4057qib7 16303 22 doses).Results doses).result NNS cord-005453-4057qib7 16303 23 : : : cord-005453-4057qib7 16303 24 Follow follow VB cord-005453-4057qib7 16303 25 - - HYPH cord-005453-4057qib7 16303 26 up up NN cord-005453-4057qib7 16303 27 was be VBD cord-005453-4057qib7 16303 28 6 6 CD cord-005453-4057qib7 16303 29 to to TO cord-005453-4057qib7 16303 30 118 118 CD cord-005453-4057qib7 16303 31 months month NNS cord-005453-4057qib7 16303 32 . . . cord-005453-4057qib7 16304 1 Good good JJ cord-005453-4057qib7 16304 2 overall overall JJ cord-005453-4057qib7 16304 3 engraftment engraftment NN cord-005453-4057qib7 16304 4 was be VBD cord-005453-4057qib7 16304 5 noted note VBN cord-005453-4057qib7 16304 6 , , , cord-005453-4057qib7 16304 7 with with IN cord-005453-4057qib7 16304 8 n=1 n=1 JJ cord-005453-4057qib7 16304 9 secondary secondary JJ cord-005453-4057qib7 16304 10 graft graft NN cord-005453-4057qib7 16304 11 failure failure NN cord-005453-4057qib7 16304 12 followed follow VBN cord-005453-4057qib7 16304 13 by by IN cord-005453-4057qib7 16304 14 successful successful JJ cord-005453-4057qib7 16304 15 retransplantation retransplantation NN cord-005453-4057qib7 16304 16 . . . cord-005453-4057qib7 16305 1 In in IN cord-005453-4057qib7 16305 2 one one CD cord-005453-4057qib7 16305 3 patient patient NN cord-005453-4057qib7 16305 4 a a DT cord-005453-4057qib7 16305 5 stem stem NN cord-005453-4057qib7 16305 6 cell cell NN cord-005453-4057qib7 16305 7 boost boost NN cord-005453-4057qib7 16305 8 / / SYM cord-005453-4057qib7 16305 9 DLI DLI NNP cord-005453-4057qib7 16305 10 was be VBD cord-005453-4057qib7 16305 11 necessary necessary JJ cord-005453-4057qib7 16305 12 due due IN cord-005453-4057qib7 16305 13 to to IN cord-005453-4057qib7 16305 14 decreasing decrease VBG cord-005453-4057qib7 16305 15 myeloid myeloid JJ cord-005453-4057qib7 16305 16 donor donor NN cord-005453-4057qib7 16305 17 chimerism chimerism NN cord-005453-4057qib7 16305 18 during during IN cord-005453-4057qib7 16305 19 EBV EBV NNP cord-005453-4057qib7 16305 20 reactivation reactivation NN cord-005453-4057qib7 16305 21 , , , cord-005453-4057qib7 16305 22 resulting result VBG cord-005453-4057qib7 16305 23 in in IN cord-005453-4057qib7 16305 24 rapid rapid JJ cord-005453-4057qib7 16305 25 myeloid myeloid JJ cord-005453-4057qib7 16305 26 donor donor NN cord-005453-4057qib7 16305 27 reconstitution reconstitution NN cord-005453-4057qib7 16305 28 after after IN cord-005453-4057qib7 16305 29 intervention intervention NN cord-005453-4057qib7 16305 30 . . . cord-005453-4057qib7 16306 1 Low low JJ cord-005453-4057qib7 16306 2 rates rate NNS cord-005453-4057qib7 16306 3 of of IN cord-005453-4057qib7 16306 4 GvHD GvHD NNP cord-005453-4057qib7 16306 5 were be VBD cord-005453-4057qib7 16306 6 documented document VBN cord-005453-4057qib7 16306 7 with with IN cord-005453-4057qib7 16306 8 n=2 n=2 NNS cord-005453-4057qib7 16306 9 aGvHD aGvHD . cord-005453-4057qib7 16306 10 grade grade NN cord-005453-4057qib7 16306 11 IV IV NNP cord-005453-4057qib7 16306 12 and and CC cord-005453-4057qib7 16306 13 n=2mild n=2mild CD cord-005453-4057qib7 16306 14 / / SYM cord-005453-4057qib7 16306 15 limited limited JJ cord-005453-4057qib7 16306 16 cGvHD cgvhd NN cord-005453-4057qib7 16306 17 ( ( -LRB- cord-005453-4057qib7 16306 18 NIH NIH NNP cord-005453-4057qib7 16306 19 criteria criterion NNS cord-005453-4057qib7 16306 20 ) ) -RRB- cord-005453-4057qib7 16306 21 . . . cord-005453-4057qib7 16307 1 With with IN cord-005453-4057qib7 16307 2 exception exception NN cord-005453-4057qib7 16307 3 of of IN cord-005453-4057qib7 16307 4 one one CD cord-005453-4057qib7 16307 5 patient patient NN cord-005453-4057qib7 16307 6 , , , cord-005453-4057qib7 16307 7 myeloid myeloid JJ cord-005453-4057qib7 16307 8 donor donor NN cord-005453-4057qib7 16307 9 chimerism chimerism NN cord-005453-4057qib7 16307 10 at at IN cord-005453-4057qib7 16307 11 last last JJ cord-005453-4057qib7 16307 12 follow follow NN cord-005453-4057qib7 16307 13 - - HYPH cord-005453-4057qib7 16307 14 up up NN cord-005453-4057qib7 16307 15 was be VBD cord-005453-4057qib7 16307 16 over over IN cord-005453-4057qib7 16307 17 82 82 CD cord-005453-4057qib7 16307 18 % % NN cord-005453-4057qib7 16307 19 , , , cord-005453-4057qib7 16307 20 mostly mostly RB cord-005453-4057qib7 16307 21 over over IN cord-005453-4057qib7 16307 22 95 95 CD cord-005453-4057qib7 16307 23 % % NN cord-005453-4057qib7 16307 24 . . . cord-005453-4057qib7 16308 1 Overall overall JJ cord-005453-4057qib7 16308 2 survival survival NN cord-005453-4057qib7 16308 3 was be VBD cord-005453-4057qib7 16308 4 31/34 31/34 CD cord-005453-4057qib7 16308 5 ( ( -LRB- cord-005453-4057qib7 16308 6 91 91 CD cord-005453-4057qib7 16308 7 % % NN cord-005453-4057qib7 16308 8 ) ) -RRB- cord-005453-4057qib7 16308 9 . . . cord-005453-4057qib7 16309 1 Deaths death NNS cord-005453-4057qib7 16309 2 were be VBD cord-005453-4057qib7 16309 3 due due JJ cord-005453-4057qib7 16309 4 to to IN cord-005453-4057qib7 16309 5 GI GI NNP cord-005453-4057qib7 16309 6 - - HYPH cord-005453-4057qib7 16309 7 GvHD GvHD NNP cord-005453-4057qib7 16309 8 ( ( -LRB- cord-005453-4057qib7 16309 9 n=1 n=1 CD cord-005453-4057qib7 16309 10 ) ) -RRB- cord-005453-4057qib7 16309 11 , , , cord-005453-4057qib7 16309 12 autoimmune autoimmune JJ cord-005453-4057qib7 16309 13 hemolytic hemolytic JJ cord-005453-4057qib7 16309 14 anemia anemia NN cord-005453-4057qib7 16309 15 / / SYM cord-005453-4057qib7 16309 16 sepsis sepsis NN cord-005453-4057qib7 16309 17 ( ( -LRB- cord-005453-4057qib7 16309 18 n=1 n=1 FW cord-005453-4057qib7 16309 19 ) ) -RRB- cord-005453-4057qib7 16309 20 and and CC cord-005453-4057qib7 16309 21 thrombotic thrombotic JJ cord-005453-4057qib7 16309 22 microangiopathy microangiopathy NNP cord-005453-4057qib7 16310 1 ( ( -LRB- cord-005453-4057qib7 16310 2 n=1).Conclusions n=1).conclusion NNS cord-005453-4057qib7 16310 3 : : : cord-005453-4057qib7 16310 4 Precision precision NN cord-005453-4057qib7 16310 5 dosing dosing NN cord-005453-4057qib7 16310 6 of of IN cord-005453-4057qib7 16310 7 iv iv NNP cord-005453-4057qib7 16310 8 Busulfan Busulfan NNP cord-005453-4057qib7 16310 9 in in IN cord-005453-4057qib7 16310 10 combination combination NN cord-005453-4057qib7 16310 11 with with IN cord-005453-4057qib7 16310 12 Fludarabine Fludarabine NNP cord-005453-4057qib7 16310 13 and and CC cord-005453-4057qib7 16310 14 serotherapy serotherapy NN cord-005453-4057qib7 16310 15 results result NNS cord-005453-4057qib7 16310 16 in in IN cord-005453-4057qib7 16310 17 excellent excellent JJ cord-005453-4057qib7 16310 18 outcome outcome NN cord-005453-4057qib7 16310 19 of of IN cord-005453-4057qib7 16310 20 HSCT HSCT NNP cord-005453-4057qib7 16310 21 for for IN cord-005453-4057qib7 16310 22 pediatric pediatric JJ cord-005453-4057qib7 16310 23 CGD CGD NNP cord-005453-4057qib7 16310 24 - - HYPH cord-005453-4057qib7 16310 25 patients patient NNS cord-005453-4057qib7 16310 26 with with IN cord-005453-4057qib7 16310 27 good good JJ cord-005453-4057qib7 16310 28 engraftment engraftment NN cord-005453-4057qib7 16310 29 , , , cord-005453-4057qib7 16310 30 low low JJ cord-005453-4057qib7 16310 31 overall overall JJ cord-005453-4057qib7 16310 32 cGvHD cgvhd NN cord-005453-4057qib7 16310 33 rates rate NNS cord-005453-4057qib7 16310 34 and and CC cord-005453-4057qib7 16310 35 stable stable JJ cord-005453-4057qib7 16310 36 , , , cord-005453-4057qib7 16310 37 mostly mostly RB cord-005453-4057qib7 16310 38 excellent excellent JJ cord-005453-4057qib7 16310 39 donor donor NN cord-005453-4057qib7 16310 40 chimerism chimerism NN cord-005453-4057qib7 16310 41 . . . cord-005453-4057qib7 16311 1 Graft graft NN cord-005453-4057qib7 16311 2 failure failure NN cord-005453-4057qib7 16311 3 rate rate NN cord-005453-4057qib7 16311 4 was be VBD cord-005453-4057qib7 16311 5 as as RB cord-005453-4057qib7 16311 6 low low JJ cord-005453-4057qib7 16311 7 as as IN cord-005453-4057qib7 16311 8 3 3 CD cord-005453-4057qib7 16311 9 % % NN cord-005453-4057qib7 16311 10 . . . cord-005453-4057qib7 16312 1 Low low JJ cord-005453-4057qib7 16312 2 dose dose NN cord-005453-4057qib7 16312 3 Alemtuzumab Alemtuzumab NNP cord-005453-4057qib7 16312 4 prevented prevent VBD cord-005453-4057qib7 16312 5 GVHD GVHD NNP cord-005453-4057qib7 16312 6 in in IN cord-005453-4057qib7 16312 7 the the DT cord-005453-4057qib7 16312 8 majority majority NN cord-005453-4057qib7 16312 9 of of IN cord-005453-4057qib7 16312 10 patients patient NNS cord-005453-4057qib7 16312 11 . . . cord-005453-4057qib7 16313 1 This this DT cord-005453-4057qib7 16313 2 analysis analysis NN cord-005453-4057qib7 16313 3 demonstrates demonstrate VBZ cord-005453-4057qib7 16313 4 that that IN cord-005453-4057qib7 16313 5 targeted target VBN cord-005453-4057qib7 16313 6 Busulfan Busulfan NNP cord-005453-4057qib7 16313 7 - - HYPH cord-005453-4057qib7 16313 8 based base VBN cord-005453-4057qib7 16313 9 conditioning conditioning NN cord-005453-4057qib7 16313 10 is be VBZ cord-005453-4057qib7 16313 11 a a DT cord-005453-4057qib7 16313 12 valid valid JJ cord-005453-4057qib7 16313 13 option option NN cord-005453-4057qib7 16313 14 for for IN cord-005453-4057qib7 16313 15 pediatric pediatric JJ cord-005453-4057qib7 16313 16 CGD CGD NNP cord-005453-4057qib7 16313 17 - - HYPH cord-005453-4057qib7 16313 18 patients patient NNS cord-005453-4057qib7 16313 19 . . . cord-005453-4057qib7 16314 1 Serum serum NN cord-005453-4057qib7 16314 2 alemtuzumab alemtuzumab NNS cord-005453-4057qib7 16314 3 or or CC cord-005453-4057qib7 16314 4 ATG ATG NNP cord-005453-4057qib7 16314 5 monitoring monitoring NN cord-005453-4057qib7 16314 6 could could MD cord-005453-4057qib7 16314 7 further further RB cord-005453-4057qib7 16314 8 improve improve VB cord-005453-4057qib7 16314 9 GF GF NNP cord-005453-4057qib7 16314 10 and and CC cord-005453-4057qib7 16314 11 GVHD GVHD NNP cord-005453-4057qib7 16314 12 rates rate NNS cord-005453-4057qib7 16314 13 in in IN cord-005453-4057qib7 16314 14 the the DT cord-005453-4057qib7 16314 15 future future NN cord-005453-4057qib7 16314 16 . . . cord-005453-4057qib7 16315 1 Disclosure disclosure NN cord-005453-4057qib7 16315 2 : : : cord-005453-4057qib7 16316 1 The the DT cord-005453-4057qib7 16316 2 authors author NNS cord-005453-4057qib7 16316 3 declare declare VBP cord-005453-4057qib7 16316 4 no no DT cord-005453-4057qib7 16316 5 conflict conflict NN cord-005453-4057qib7 16316 6 of of IN cord-005453-4057qib7 16316 7 interest interest NN cord-005453-4057qib7 16316 8 . . . cord-005453-4057qib7 16317 1 Abstract Abstract NNP cord-005453-4057qib7 16317 2 already already RB cord-005453-4057qib7 16317 3 published publish VBN cord-005453-4057qib7 16317 4 . . . cord-005453-4057qib7 16318 1 Young Young NNP cord-005453-4057qib7 16318 2 HLA HLA NNP cord-005453-4057qib7 16318 3 - - HYPH cord-005453-4057qib7 16318 4 matched match VBN cord-005453-4057qib7 16318 5 unrelated unrelated JJ cord-005453-4057qib7 16318 6 donors donor NNS cord-005453-4057qib7 16318 7 are be VBP cord-005453-4057qib7 16318 8 comparable comparable JJ cord-005453-4057qib7 16318 9 to to IN cord-005453-4057qib7 16318 10 matched match VBN cord-005453-4057qib7 16318 11 sibling sibling NN cord-005453-4057qib7 16318 12 donors donor NNS cord-005453-4057qib7 16318 13 in in IN cord-005453-4057qib7 16318 14 elderly elderly JJ cord-005453-4057qib7 16318 15 patients patient NNS cord-005453-4057qib7 16318 16 receiving receive VBG cord-005453-4057qib7 16318 17 reduced reduce VBN cord-005453-4057qib7 16318 18 - - HYPH cord-005453-4057qib7 16318 19 intensity intensity NN cord-005453-4057qib7 16318 20 conditioning conditioning NN cord-005453-4057qib7 16318 21 : : : cord-005453-4057qib7 16318 22 an an DT cord-005453-4057qib7 16318 23 analysis analysis NN cord-005453-4057qib7 16318 24 on on IN cord-005453-4057qib7 16318 25 behalf behalf NN cord-005453-4057qib7 16318 26 of of IN cord-005453-4057qib7 16318 27 the the DT cord-005453-4057qib7 16318 28 EBMT EBMT NNP cord-005453-4057qib7 16318 29 scientific scientific JJ cord-005453-4057qib7 16318 30 council council NN cord-005453-4057qib7 16318 31 95 95 CD cord-005453-4057qib7 16318 32 % % NN cord-005453-4057qib7 16318 33 C.I. C.I. NNP cord-005453-4057qib7 16318 34 1.7 1.7 CD cord-005453-4057qib7 16318 35 - - SYM cord-005453-4057qib7 16318 36 20.6 20.6 CD cord-005453-4057qib7 16318 37 , , , cord-005453-4057qib7 16318 38 p= p= NN cord-005453-4057qib7 16318 39 0.001 0.001 CD cord-005453-4057qib7 16318 40 ) ) -RRB- cord-005453-4057qib7 16318 41 and and CC cord-005453-4057qib7 16318 42 voriconazol voriconazol NN cord-005453-4057qib7 16318 43 prophylaxis prophylaxis NN cord-005453-4057qib7 16318 44 during during IN cord-005453-4057qib7 16318 45 CARV CARV NNP cord-005453-4057qib7 16318 46 ( ( -LRB- cord-005453-4057qib7 16318 47 OR or CC cord-005453-4057qib7 16319 1 4.2 4.2 CD cord-005453-4057qib7 16319 2 , , , cord-005453-4057qib7 16319 3 95 95 CD cord-005453-4057qib7 16319 4 % % NN cord-005453-4057qib7 16319 5 C.I. C.I. NNP cord-005453-4057qib7 16319 6 1.1 1.1 CD cord-005453-4057qib7 16319 7 - - HYPH cord-005453-4057qib7 16319 8 115.6 115.6 CD cord-005453-4057qib7 16319 9 , , , cord-005453-4057qib7 16319 10 p= p= NN cord-005453-4057qib7 16319 11 0.03 0.03 CD cord-005453-4057qib7 16319 12 ) ) -RRB- cord-005453-4057qib7 16319 13 . . . cord-005453-4057qib7 16320 1 Conclusions conclusion NNS cord-005453-4057qib7 16320 2 : : : cord-005453-4057qib7 16321 1 We -PRON- PRP cord-005453-4057qib7 16321 2 provide provide VBP cord-005453-4057qib7 16321 3 evidence evidence NN cord-005453-4057qib7 16321 4 that that IN cord-005453-4057qib7 16321 5 IFD IFD NNP cord-005453-4057qib7 16321 6 after after IN cord-005453-4057qib7 16321 7 CARV CARV NNP cord-005453-4057qib7 16321 8 infection infection NN cord-005453-4057qib7 16321 9 . . . cord-005453-4057qib7 16322 1 Allo Allo NNP cord-005453-4057qib7 16322 2 - - HYPH cord-005453-4057qib7 16322 3 HSCT HSCT NNP cord-005453-4057qib7 16322 4 recipients recipient NNS cord-005453-4057qib7 16322 5 developing develop VBG cord-005453-4057qib7 16322 6 a a DT cord-005453-4057qib7 16322 7 CARV CARV NNP cord-005453-4057qib7 16322 8 LRTD LRTD NNP cord-005453-4057qib7 16322 9 during during IN cord-005453-4057qib7 16322 10 the the DT cord-005453-4057qib7 16322 11 first first JJ cord-005453-4057qib7 16322 12 year year NN cord-005453-4057qib7 16322 13 after after IN cord-005453-4057qib7 16322 14 transplant transplant NN cord-005453-4057qib7 16322 15 may may MD cord-005453-4057qib7 16322 16 benefit benefit VB cord-005453-4057qib7 16322 17 from from IN cord-005453-4057qib7 16322 18 an an DT cord-005453-4057qib7 16322 19 adequate adequate JJ cord-005453-4057qib7 16322 20 antifungal antifungal NN cord-005453-4057qib7 16322 21 prophylaxis prophylaxis NN cord-005453-4057qib7 16322 22 and and CC cord-005453-4057qib7 16322 23 a a DT cord-005453-4057qib7 16322 24 close close JJ cord-005453-4057qib7 16322 25 monitoring monitoring NN cord-005453-4057qib7 16322 26 for for IN cord-005453-4057qib7 16322 27 the the DT cord-005453-4057qib7 16322 28 development development NN cord-005453-4057qib7 16322 29 of of IN cord-005453-4057qib7 16322 30 a a DT cord-005453-4057qib7 16322 31 later later JJ cord-005453-4057qib7 16322 32 IFD.Disclosure ifd.disclosure NN cord-005453-4057qib7 16322 33 : : : cord-005453-4057qib7 16323 1 Jose Jose NNP cord-005453-4057qib7 16323 2 Luis Luis NNP cord-005453-4057qib7 16323 3 Piñana Piñana NNP cord-005453-4057qib7 16323 4 has have VBZ cord-005453-4057qib7 16323 5 received receive VBN cord-005453-4057qib7 16323 6 both both DT cord-005453-4057qib7 16323 7 , , , cord-005453-4057qib7 16323 8 advisory advisory JJ cord-005453-4057qib7 16323 9 for for IN cord-005453-4057qib7 16323 10 preclinical preclinical JJ cord-005453-4057qib7 16323 11 / / SYM cord-005453-4057qib7 16323 12 clinical clinical JJ cord-005453-4057qib7 16323 13 research research NN cord-005453-4057qib7 16323 14 and and CC cord-005453-4057qib7 16323 15 financial financial JJ cord-005453-4057qib7 16323 16 support support NN cord-005453-4057qib7 16323 17 to to TO cord-005453-4057qib7 16323 18 assist assist VB cord-005453-4057qib7 16323 19 to to IN cord-005453-4057qib7 16323 20 the the DT cord-005453-4057qib7 16323 21 Spanish spanish JJ cord-005453-4057qib7 16323 22 society society NN cord-005453-4057qib7 16323 23 of of IN cord-005453-4057qib7 16323 24 hematology hematology NNP cord-005453-4057qib7 16323 25 annual annual JJ cord-005453-4057qib7 16323 26 meeting meeting NN cord-005453-4057qib7 16323 27 2018 2018 CD cord-005453-4057qib7 16323 28 from from IN cord-005453-4057qib7 16323 29 MSD MSD NNP cord-005453-4057qib7 16323 30 . . . cord-005453-4057qib7 16324 1 Favorable favorable JJ cord-005453-4057qib7 16324 2 outcome outcome NN cord-005453-4057qib7 16324 3 and and CC cord-005453-4057qib7 16324 4 engraftment engraftment NN cord-005453-4057qib7 16324 5 following follow VBG cord-005453-4057qib7 16324 6 reducedintensity reducedintensity NN cord-005453-4057qib7 16324 7 conditioned condition VBN cord-005453-4057qib7 16324 8 allo allo NN cord-005453-4057qib7 16324 9 - - HYPH cord-005453-4057qib7 16324 10 HSCT HSCT NNP cord-005453-4057qib7 16324 11 in in IN cord-005453-4057qib7 16324 12 children child NNS cord-005453-4057qib7 16324 13 with with IN cord-005453-4057qib7 16324 14 primary primary JJ cord-005453-4057qib7 16324 15 haemophagocytic haemophagocytic JJ cord-005453-4057qib7 16324 16 lymphohistiocytosis lymphohistiocytosis NN cord-005453-4057qib7 16324 17 ( ( -LRB- cord-005453-4057qib7 16324 18 HLH HLH NNP cord-005453-4057qib7 16324 19 ) ) -RRB- cord-005453-4057qib7 16324 20 and and CC cord-005453-4057qib7 16324 21 high high JJ cord-005453-4057qib7 16324 22 - - HYPH cord-005453-4057qib7 16324 23 risk risk NN cord-005453-4057qib7 16324 24 langerhans langerhans NNP cord-005453-4057qib7 16324 25 cell cell NN cord-005453-4057qib7 16324 26 histiocytosis histiocytosis NN cord-005453-4057qib7 16324 27 ( ( -LRB- cord-005453-4057qib7 16324 28 LCH LCH NNP cord-005453-4057qib7 16324 29 ) ) -RRB- cord-005453-4057qib7 16324 30 Laura Laura NNP cord-005453-4057qib7 16324 31 M. M. NNP cord-005453-4057qib7 16324 32 Moser Moser NNP cord-005453-4057qib7 16324 33 , , , cord-005453-4057qib7 16324 34 Emilia Emilia NNP cord-005453-4057qib7 16324 35 Salzmann Salzmann NNP cord-005453-4057qib7 16324 36 - - HYPH cord-005453-4057qib7 16324 37 Manrique Manrique NNP cord-005453-4057qib7 16324 38 , , , cord-005453-4057qib7 16324 39 Andrea Andrea NNP cord-005453-4057qib7 16324 40 Jarisch Jarisch NNP cord-005453-4057qib7 16324 41 , , , cord-005453-4057qib7 16324 42 Jan Jan NNP cord-005453-4057qib7 16324 43 Sörensen Sörensen NNP cord-005453-4057qib7 16324 44 , , , cord-005453-4057qib7 16324 45 Shahrzad Shahrzad NNP cord-005453-4057qib7 16324 46 Bakhtiar Bakhtiar NNP cord-005453-4057qib7 16324 47 , , , cord-005453-4057qib7 16324 48 Peter Peter NNP cord-005453-4057qib7 16324 49 Bader Bader NNP cord-005453-4057qib7 16324 50 Background Background NNP cord-005453-4057qib7 16324 51 : : : cord-005453-4057qib7 16324 52 Primary primary JJ cord-005453-4057qib7 16324 53 haemophagocytic haemophagocytic JJ cord-005453-4057qib7 16324 54 lymphohistiocytosis lymphohistiocytosis NN cord-005453-4057qib7 16324 55 ( ( -LRB- cord-005453-4057qib7 16324 56 HLH HLH NNP cord-005453-4057qib7 16324 57 ) ) -RRB- cord-005453-4057qib7 16324 58 and and CC cord-005453-4057qib7 16324 59 high high JJ cord-005453-4057qib7 16324 60 - - HYPH cord-005453-4057qib7 16324 61 risk risk NN cord-005453-4057qib7 16324 62 Langerhans Langerhans NNP cord-005453-4057qib7 16324 63 cell cell NN cord-005453-4057qib7 16324 64 histiocytosis histiocytosis NN cord-005453-4057qib7 16325 1 ( ( -LRB- cord-005453-4057qib7 16325 2 LCH LCH NNP cord-005453-4057qib7 16325 3 ) ) -RRB- cord-005453-4057qib7 16325 4 represent represent VBP cord-005453-4057qib7 16325 5 two two CD cord-005453-4057qib7 16325 6 major major JJ cord-005453-4057qib7 16325 7 entities entity NNS cord-005453-4057qib7 16325 8 of of IN cord-005453-4057qib7 16325 9 childhood childhood NN cord-005453-4057qib7 16325 10 histiocytoses histiocytose NNS cord-005453-4057qib7 16325 11 , , , cord-005453-4057qib7 16325 12 which which WDT cord-005453-4057qib7 16325 13 are be VBP cord-005453-4057qib7 16325 14 -although -although : cord-005453-4057qib7 16325 15 only only RB cord-005453-4057qib7 16325 16 of of IN cord-005453-4057qib7 16325 17 rare rare JJ cord-005453-4057qib7 16325 18 occurrence occurrence NN cord-005453-4057qib7 16326 1 -severe -severe JJ cord-005453-4057qib7 16327 1 in in IN cord-005453-4057qib7 16327 2 their -PRON- PRP$ cord-005453-4057qib7 16327 3 clinical clinical JJ cord-005453-4057qib7 16327 4 manifestations manifestation NNS cord-005453-4057qib7 16327 5 . . . cord-005453-4057qib7 16328 1 Patients patient NNS cord-005453-4057qib7 16328 2 present present JJ cord-005453-4057qib7 16328 3 with with IN cord-005453-4057qib7 16328 4 multisystemic multisystemic JJ cord-005453-4057qib7 16328 5 uncontrolled uncontrolled JJ cord-005453-4057qib7 16328 6 inflammation inflammation NN cord-005453-4057qib7 16328 7 and and CC cord-005453-4057qib7 16328 8 multi multi JJ cord-005453-4057qib7 16328 9 - - JJ cord-005453-4057qib7 16328 10 organ organ JJ cord-005453-4057qib7 16328 11 involvement involvement NN cord-005453-4057qib7 16328 12 requiring require VBG cord-005453-4057qib7 16328 13 diverse diverse JJ cord-005453-4057qib7 16328 14 courses course NNS cord-005453-4057qib7 16328 15 of of IN cord-005453-4057qib7 16328 16 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 16328 17 and and CC cord-005453-4057qib7 16328 18 chemotherapy chemotherapy NN cord-005453-4057qib7 16328 19 regimens regimen NNS cord-005453-4057qib7 16328 20 . . . cord-005453-4057qib7 16329 1 Allogeneic allogeneic IN cord-005453-4057qib7 16329 2 haematopoietic haematopoietic JJ cord-005453-4057qib7 16329 3 stem stem NN cord-005453-4057qib7 16329 4 cell cell NN cord-005453-4057qib7 16329 5 transplantation transplantation NN cord-005453-4057qib7 16329 6 ( ( -LRB- cord-005453-4057qib7 16329 7 alloHSCT alloHSCT NNP cord-005453-4057qib7 16329 8 ) ) -RRB- cord-005453-4057qib7 16329 9 is be VBZ cord-005453-4057qib7 16329 10 the the DT cord-005453-4057qib7 16329 11 only only RB cord-005453-4057qib7 16329 12 available available JJ cord-005453-4057qib7 16329 13 curative curative JJ cord-005453-4057qib7 16329 14 option option NN cord-005453-4057qib7 16329 15 ; ; : cord-005453-4057qib7 16329 16 however however RB cord-005453-4057qib7 16329 17 , , , cord-005453-4057qib7 16329 18 the the DT cord-005453-4057qib7 16329 19 cumulative cumulative JJ cord-005453-4057qib7 16329 20 treatment treatment NN cord-005453-4057qib7 16329 21 toxicity toxicity NN cord-005453-4057qib7 16329 22 and and CC cord-005453-4057qib7 16329 23 the the DT cord-005453-4057qib7 16329 24 underlying underlying JJ cord-005453-4057qib7 16329 25 inflammatory inflammatory JJ cord-005453-4057qib7 16329 26 disease disease NN cord-005453-4057qib7 16329 27 often often RB cord-005453-4057qib7 16329 28 result result VBP cord-005453-4057qib7 16329 29 in in IN cord-005453-4057qib7 16329 30 high high JJ cord-005453-4057qib7 16329 31 organ organ NN cord-005453-4057qib7 16329 32 toxicity toxicity NN cord-005453-4057qib7 16329 33 and and CC cord-005453-4057qib7 16329 34 inflammatory inflammatory JJ cord-005453-4057qib7 16329 35 complications complication NNS cord-005453-4057qib7 16329 36 of of IN cord-005453-4057qib7 16329 37 transplantation transplantation NN cord-005453-4057qib7 16329 38 , , , cord-005453-4057qib7 16329 39 such such JJ cord-005453-4057qib7 16329 40 as as IN cord-005453-4057qib7 16329 41 Graft graft NN cord-005453-4057qib7 16329 42 versus versus IN cord-005453-4057qib7 16329 43 Host Host NNP cord-005453-4057qib7 16329 44 Disease Disease NNP cord-005453-4057qib7 16329 45 ( ( -LRB- cord-005453-4057qib7 16329 46 GVHD GVHD NNP cord-005453-4057qib7 16329 47 ) ) -RRB- cord-005453-4057qib7 16330 1 and/or and/or CC cord-005453-4057qib7 16330 2 graft graft NN cord-005453-4057qib7 16330 3 failure failure NN cord-005453-4057qib7 16330 4 . . . cord-005453-4057qib7 16331 1 Especially especially RB cord-005453-4057qib7 16331 2 patients patient NNS cord-005453-4057qib7 16331 3 with with IN cord-005453-4057qib7 16331 4 unrelated unrelated JJ cord-005453-4057qib7 16331 5 donors donor NNS cord-005453-4057qib7 16331 6 often often RB cord-005453-4057qib7 16331 7 deal deal VBP cord-005453-4057qib7 16331 8 with with IN cord-005453-4057qib7 16331 9 high high JJ cord-005453-4057qib7 16331 10 transplant transplant NN cord-005453-4057qib7 16331 11 - - HYPH cord-005453-4057qib7 16331 12 related relate VBN cord-005453-4057qib7 16331 13 mortality mortality NN cord-005453-4057qib7 16331 14 ( ( -LRB- cord-005453-4057qib7 16331 15 TRM TRM NNP cord-005453-4057qib7 16331 16 ) ) -RRB- cord-005453-4057qib7 16331 17 in in IN cord-005453-4057qib7 16331 18 the the DT cord-005453-4057qib7 16331 19 setting setting NN cord-005453-4057qib7 16331 20 of of IN cord-005453-4057qib7 16331 21 conventional conventional JJ cord-005453-4057qib7 16331 22 intensity intensity NN cord-005453-4057qib7 16331 23 conditioning conditioning NN cord-005453-4057qib7 16331 24 . . . cord-005453-4057qib7 16332 1 Herein herein RB cord-005453-4057qib7 16332 2 , , , cord-005453-4057qib7 16332 3 we -PRON- PRP cord-005453-4057qib7 16332 4 present present VBP cord-005453-4057qib7 16332 5 the the DT cord-005453-4057qib7 16332 6 clinical clinical JJ cord-005453-4057qib7 16332 7 course course NN cord-005453-4057qib7 16332 8 of of IN cord-005453-4057qib7 16332 9 the the DT cord-005453-4057qib7 16332 10 disease disease NN cord-005453-4057qib7 16332 11 and and CC cord-005453-4057qib7 16332 12 transplant transplant NN cord-005453-4057qib7 16332 13 outcome outcome NN cord-005453-4057qib7 16332 14 of of IN cord-005453-4057qib7 16332 15 14 14 CD cord-005453-4057qib7 16332 16 children child NNS cord-005453-4057qib7 16332 17 diagnosed diagnose VBN cord-005453-4057qib7 16332 18 with with IN cord-005453-4057qib7 16332 19 primary primary JJ cord-005453-4057qib7 16332 20 HLH HLH NNP cord-005453-4057qib7 16332 21 ( ( -LRB- cord-005453-4057qib7 16332 22 n=12 n=12 NNP cord-005453-4057qib7 16332 23 ) ) -RRB- cord-005453-4057qib7 16332 24 and and CC cord-005453-4057qib7 16332 25 high high JJ cord-005453-4057qib7 16332 26 - - HYPH cord-005453-4057qib7 16332 27 risk risk NN cord-005453-4057qib7 16332 28 LCH LCH NNP cord-005453-4057qib7 16332 29 ( ( -LRB- cord-005453-4057qib7 16332 30 n=3 n=3 NN cord-005453-4057qib7 16332 31 ) ) -RRB- cord-005453-4057qib7 16332 32 who who WP cord-005453-4057qib7 16332 33 underwent undergo VBD cord-005453-4057qib7 16332 34 alloHSCT alloHSCT NNP cord-005453-4057qib7 16332 35 at at IN cord-005453-4057qib7 16332 36 our -PRON- PRP$ cord-005453-4057qib7 16332 37 centre centre NN cord-005453-4057qib7 16332 38 from from IN cord-005453-4057qib7 16332 39 02/2003 02/2003 CD cord-005453-4057qib7 16332 40 to to IN cord-005453-4057qib7 16332 41 08/2018.Methods 08/2018.methods CD cord-005453-4057qib7 16332 42 : : : cord-005453-4057qib7 16333 1 The the DT cord-005453-4057qib7 16333 2 HLH HLH NNP cord-005453-4057qib7 16333 3 cohort cohort NN cord-005453-4057qib7 16333 4 consisted consist VBD cord-005453-4057qib7 16333 5 of of IN cord-005453-4057qib7 16333 6 7 7 CD cord-005453-4057qib7 16333 7 cases case NNS cord-005453-4057qib7 16333 8 of of IN cord-005453-4057qib7 16333 9 familial familial JJ cord-005453-4057qib7 16333 10 HLH HLH NNP cord-005453-4057qib7 16333 11 ( ( -LRB- cord-005453-4057qib7 16333 12 fHLH fhlh NN cord-005453-4057qib7 16333 13 ) ) -RRB- cord-005453-4057qib7 16333 14 , , , cord-005453-4057qib7 16333 15 4 4 CD cord-005453-4057qib7 16333 16 cases case NNS cord-005453-4057qib7 16333 17 of of IN cord-005453-4057qib7 16333 18 Griscelli Griscelli NNP cord-005453-4057qib7 16333 19 syndrome syndrome NN cord-005453-4057qib7 16333 20 , , , cord-005453-4057qib7 16333 21 one one CD cord-005453-4057qib7 16333 22 XIAP xiap NN cord-005453-4057qib7 16333 23 - - HYPH cord-005453-4057qib7 16333 24 deficient deficient JJ cord-005453-4057qib7 16333 25 patient patient NN cord-005453-4057qib7 16333 26 and and CC cord-005453-4057qib7 16333 27 one one CD cord-005453-4057qib7 16333 28 HLH HLH NNP cord-005453-4057qib7 16333 29 - - HYPH cord-005453-4057qib7 16333 30 patient patient NN cord-005453-4057qib7 16333 31 with with IN cord-005453-4057qib7 16333 32 inconclusive inconclusive JJ cord-005453-4057qib7 16333 33 genetic genetic JJ cord-005453-4057qib7 16333 34 testing testing NN cord-005453-4057qib7 16333 35 . . . cord-005453-4057qib7 16334 1 All all DT cord-005453-4057qib7 16334 2 HLH HLH NNP cord-005453-4057qib7 16334 3 patients patient NNS cord-005453-4057qib7 16334 4 had have VBD cord-005453-4057qib7 16334 5 developed develop VBN cord-005453-4057qib7 16334 6 clinical clinical JJ cord-005453-4057qib7 16334 7 symptoms symptom NNS cord-005453-4057qib7 16334 8 prior prior RB cord-005453-4057qib7 16334 9 to to IN cord-005453-4057qib7 16334 10 transplantation transplantation NN cord-005453-4057qib7 16334 11 and and CC cord-005453-4057qib7 16334 12 had have VBD cord-005453-4057qib7 16334 13 been be VBN cord-005453-4057qib7 16334 14 treated treat VBN cord-005453-4057qib7 16334 15 according accord VBG cord-005453-4057qib7 16334 16 to to IN cord-005453-4057qib7 16334 17 HLH HLH NNP cord-005453-4057qib7 16334 18 - - HYPH cord-005453-4057qib7 16334 19 protocols protocol NNS cord-005453-4057qib7 16334 20 94 94 CD cord-005453-4057qib7 16334 21 , , , cord-005453-4057qib7 16334 22 2004 2004 CD cord-005453-4057qib7 16334 23 HLH HLH NNP cord-005453-4057qib7 16334 24 - - HYPH cord-005453-4057qib7 16334 25 protocols protocol NNS cord-005453-4057qib7 16334 26 94 94 CD cord-005453-4057qib7 16334 27 , , , cord-005453-4057qib7 16334 28 or or CC cord-005453-4057qib7 16334 29 2015 2015 CD cord-005453-4057qib7 16334 30 Median median JJ cord-005453-4057qib7 16334 31 age age NN cord-005453-4057qib7 16334 32 at at IN cord-005453-4057qib7 16334 33 transplantation transplantation NN cord-005453-4057qib7 16334 34 was be VBD cord-005453-4057qib7 16334 35 10 10 CD cord-005453-4057qib7 16334 36 months month NNS cord-005453-4057qib7 16334 37 ( ( -LRB- cord-005453-4057qib7 16334 38 4 4 CD cord-005453-4057qib7 16334 39 to to TO cord-005453-4057qib7 16334 40 128 128 CD cord-005453-4057qib7 16334 41 months month NNS cord-005453-4057qib7 16334 42 ) ) -RRB- cord-005453-4057qib7 16334 43 . . . cord-005453-4057qib7 16335 1 Stem stem NN cord-005453-4057qib7 16335 2 cells cell NNS cord-005453-4057qib7 16335 3 were be VBD cord-005453-4057qib7 16335 4 derived derive VBN cord-005453-4057qib7 16335 5 from from IN cord-005453-4057qib7 16335 6 HLA HLA NNP cord-005453-4057qib7 16335 7 - - HYPH cord-005453-4057qib7 16335 8 matched match VBN cord-005453-4057qib7 16335 9 siblings sibling NNS cord-005453-4057qib7 16335 10 ( ( -LRB- cord-005453-4057qib7 16335 11 MSD MSD NNP cord-005453-4057qib7 16335 12 , , , cord-005453-4057qib7 16335 13 n= n= NNP cord-005453-4057qib7 16335 14 4 4 CD cord-005453-4057qib7 16335 15 ) ) -RRB- cord-005453-4057qib7 16335 16 , , , cord-005453-4057qib7 16335 17 matched match VBD cord-005453-4057qib7 16335 18 unrelated unrelated JJ cord-005453-4057qib7 16335 19 donors donor NNS cord-005453-4057qib7 16335 20 ( ( -LRB- cord-005453-4057qib7 16335 21 MUD mud NN cord-005453-4057qib7 16335 22 , , , cord-005453-4057qib7 16335 23 n n NN cord-005453-4057qib7 16335 24 = = SYM cord-005453-4057qib7 16335 25 9 9 CD cord-005453-4057qib7 16335 26 ) ) -RRB- cord-005453-4057qib7 16335 27 or or CC cord-005453-4057qib7 16335 28 haploidentical haploidentical JJ cord-005453-4057qib7 16335 29 donors donor NNS cord-005453-4057qib7 16335 30 ( ( -LRB- cord-005453-4057qib7 16335 31 n=1).The n=1).The NNP cord-005453-4057qib7 16335 32 majority majority NN cord-005453-4057qib7 16335 33 of of IN cord-005453-4057qib7 16335 34 patients patient NNS cord-005453-4057qib7 16335 35 ( ( -LRB- cord-005453-4057qib7 16335 36 9/14 9/14 CD cord-005453-4057qib7 16335 37 ) ) -RRB- cord-005453-4057qib7 16335 38 received receive VBD cord-005453-4057qib7 16335 39 a a DT cord-005453-4057qib7 16335 40 RIC RIC NNP cord-005453-4057qib7 16335 41 regimen regimen NN cord-005453-4057qib7 16335 42 containing contain VBG cord-005453-4057qib7 16335 43 fludarabine fludarabine NN cord-005453-4057qib7 16335 44 , , , cord-005453-4057qib7 16335 45 melphalan melphalan NNP cord-005453-4057qib7 16335 46 and and CC cord-005453-4057qib7 16335 47 thiotepa thiotepa NNP cord-005453-4057qib7 16335 48 ( ( -LRB- cord-005453-4057qib7 16335 49 n=8 n=8 NN cord-005453-4057qib7 16335 50 ) ) -RRB- cord-005453-4057qib7 16335 51 and and CC cord-005453-4057qib7 16335 52 fludarabine fludarabine NN cord-005453-4057qib7 16335 53 plus plus CC cord-005453-4057qib7 16335 54 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 16335 55 ( ( -LRB- cord-005453-4057qib7 16335 56 n=1 n=1 FW cord-005453-4057qib7 16335 57 ) ) -RRB- cord-005453-4057qib7 16335 58 . . . cord-005453-4057qib7 16336 1 Myeloablative myeloablative JJ cord-005453-4057qib7 16336 2 treatment treatment NN cord-005453-4057qib7 16336 3 ( ( -LRB- cord-005453-4057qib7 16336 4 5/14 5/14 CD cord-005453-4057qib7 16336 5 ) ) -RRB- cord-005453-4057qib7 16336 6 included include VBD cord-005453-4057qib7 16336 7 a a DT cord-005453-4057qib7 16336 8 treosulfan treosulfan NN cord-005453-4057qib7 16336 9 - - HYPH cord-005453-4057qib7 16336 10 based base VBN cord-005453-4057qib7 16336 11 regimen regimen NN cord-005453-4057qib7 16336 12 ( ( -LRB- cord-005453-4057qib7 16336 13 n=3 n=3 NN cord-005453-4057qib7 16336 14 ) ) -RRB- cord-005453-4057qib7 16336 15 and and CC cord-005453-4057qib7 16336 16 busulfan busulfan NN cord-005453-4057qib7 16336 17 - - HYPH cord-005453-4057qib7 16336 18 containing contain VBG cord-005453-4057qib7 16336 19 treatment treatment NN cord-005453-4057qib7 16336 20 ( ( -LRB- cord-005453-4057qib7 16336 21 n=2 n=2 NNS cord-005453-4057qib7 16336 22 ) ) -RRB- cord-005453-4057qib7 16336 23 . . . cord-005453-4057qib7 16337 1 The the DT cord-005453-4057qib7 16337 2 entire entire JJ cord-005453-4057qib7 16337 3 cohort cohort NN cord-005453-4057qib7 16337 4 received receive VBD cord-005453-4057qib7 16337 5 serotherapy serotherapy NN cord-005453-4057qib7 16337 6 using use VBG cord-005453-4057qib7 16337 7 either either CC cord-005453-4057qib7 16337 8 muromonab muromonab NN cord-005453-4057qib7 16337 9 ( ( -LRB- cord-005453-4057qib7 16337 10 n=3 n=3 NN cord-005453-4057qib7 16337 11 ) ) -RRB- cord-005453-4057qib7 16337 12 , , , cord-005453-4057qib7 16337 13 ATG ATG NNP cord-005453-4057qib7 16337 14 - - HYPH cord-005453-4057qib7 16337 15 Fresenius Fresenius NNP cord-005453-4057qib7 16337 16 ® ® . cord-005453-4057qib7 16337 17 ( ( -LRB- cord-005453-4057qib7 16337 18 n=9 n=9 NN cord-005453-4057qib7 16337 19 ) ) -RRB- cord-005453-4057qib7 16337 20 or or CC cord-005453-4057qib7 16337 21 alemtuzumab alemtuzumab NNP cord-005453-4057qib7 16338 1 ( ( -LRB- cord-005453-4057qib7 16338 2 n=2).Results n=2).result NNS cord-005453-4057qib7 16338 3 : : : cord-005453-4057qib7 16339 1 The the DT cord-005453-4057qib7 16339 2 overall overall JJ cord-005453-4057qib7 16339 3 survival survival NN cord-005453-4057qib7 16339 4 of of IN cord-005453-4057qib7 16339 5 the the DT cord-005453-4057qib7 16339 6 entire entire JJ cord-005453-4057qib7 16339 7 cohort cohort NN cord-005453-4057qib7 16339 8 was be VBD cord-005453-4057qib7 16339 9 78.6 78.6 CD cord-005453-4057qib7 16339 10 % % NN cord-005453-4057qib7 16339 11 ( ( -LRB- cord-005453-4057qib7 16339 12 11/14 11/14 CD cord-005453-4057qib7 16339 13 ) ) -RRB- cord-005453-4057qib7 16339 14 on on IN cord-005453-4057qib7 16339 15 a a DT cord-005453-4057qib7 16339 16 median median JJ cord-005453-4057qib7 16339 17 follow follow NN cord-005453-4057qib7 16339 18 - - HYPH cord-005453-4057qib7 16339 19 up up NN cord-005453-4057qib7 16339 20 of of IN cord-005453-4057qib7 16339 21 9.9 9.9 CD cord-005453-4057qib7 16339 22 years year NNS cord-005453-4057qib7 16340 1 ( ( -LRB- cord-005453-4057qib7 16340 2 Figure figure NN cord-005453-4057qib7 16340 3 _SP cord-005453-4057qib7 16340 4 1 1 CD cord-005453-4057qib7 16340 5 A+B A+B NNP cord-005453-4057qib7 16340 6 ) ) -RRB- cord-005453-4057qib7 16340 7 .All .All . cord-005453-4057qib7 16341 1 LCH LCH NNP cord-005453-4057qib7 16341 2 patients patient NNS cord-005453-4057qib7 16341 3 , , , cord-005453-4057qib7 16341 4 being be VBG cord-005453-4057qib7 16341 5 treated treat VBN cord-005453-4057qib7 16341 6 with with IN cord-005453-4057qib7 16341 7 fludarabine fludarabine NN cord-005453-4057qib7 16341 8 , , , cord-005453-4057qib7 16341 9 melphalan melphalan NNP cord-005453-4057qib7 16341 10 and and CC cord-005453-4057qib7 16341 11 thiotepa thiotepa NNP cord-005453-4057qib7 16341 12 , , , cord-005453-4057qib7 16341 13 survived survive VBD cord-005453-4057qib7 16341 14 transplantation transplantation NN cord-005453-4057qib7 16341 15 and and CC cord-005453-4057qib7 16341 16 showed show VBD cord-005453-4057qib7 16341 17 complete complete JJ cord-005453-4057qib7 16341 18 remission remission NN cord-005453-4057qib7 16341 19 ( ( -LRB- cord-005453-4057qib7 16341 20 3/3 3/3 CD cord-005453-4057qib7 16341 21 ) ) -RRB- cord-005453-4057qib7 16341 22 . . . cord-005453-4057qib7 16342 1 Within within IN cord-005453-4057qib7 16342 2 the the DT cord-005453-4057qib7 16342 3 HLH HLH NNP cord-005453-4057qib7 16342 4 cohort cohort NN cord-005453-4057qib7 16342 5 the the DT cord-005453-4057qib7 16342 6 overall overall JJ cord-005453-4057qib7 16342 7 survival survival NN cord-005453-4057qib7 16342 8 was be VBD cord-005453-4057qib7 16342 9 72.7 72.7 CD cord-005453-4057qib7 16342 10 % % NN cord-005453-4057qib7 16342 11 ( ( -LRB- cord-005453-4057qib7 16342 12 8/11 8/11 CD cord-005453-4057qib7 16342 13 ) ) -RRB- cord-005453-4057qib7 16342 14 . . . cord-005453-4057qib7 16343 1 Fatalities fatality NNS cord-005453-4057qib7 16343 2 ( ( -LRB- cord-005453-4057qib7 16343 3 n=3 n=3 NN cord-005453-4057qib7 16343 4 ) ) -RRB- cord-005453-4057qib7 16343 5 included include VBD cord-005453-4057qib7 16343 6 two two CD cord-005453-4057qib7 16343 7 patients patient NNS cord-005453-4057qib7 16343 8 from from IN cord-005453-4057qib7 16343 9 the the DT cord-005453-4057qib7 16343 10 myeloablative myeloablative NNP cord-005453-4057qib7 16343 11 group group NN cord-005453-4057qib7 16343 12 and and CC cord-005453-4057qib7 16343 13 one one CD cord-005453-4057qib7 16343 14 RIC ric NN cord-005453-4057qib7 16343 15 - - HYPH cord-005453-4057qib7 16343 16 treated treat VBN cord-005453-4057qib7 16343 17 patient patient NN cord-005453-4057qib7 16343 18 . . . cord-005453-4057qib7 16344 1 The the DT cord-005453-4057qib7 16344 2 cause cause NN cord-005453-4057qib7 16344 3 of of IN cord-005453-4057qib7 16344 4 death death NN cord-005453-4057qib7 16344 5 were be VBD cord-005453-4057qib7 16344 6 progressive progressive JJ cord-005453-4057qib7 16344 7 disease disease NN cord-005453-4057qib7 16344 8 activity activity NN cord-005453-4057qib7 16344 9 during during IN cord-005453-4057qib7 16344 10 the the DT cord-005453-4057qib7 16344 11 conditioning conditioning NN cord-005453-4057qib7 16344 12 phase phase NN cord-005453-4057qib7 16344 13 , , , cord-005453-4057qib7 16344 14 leading lead VBG cord-005453-4057qib7 16344 15 to to IN cord-005453-4057qib7 16344 16 multi multi JJ cord-005453-4057qib7 16344 17 - - JJ cord-005453-4057qib7 16344 18 organ organ JJ cord-005453-4057qib7 16344 19 failure failure NN cord-005453-4057qib7 16344 20 on on IN cord-005453-4057qib7 16344 21 day day NN cord-005453-4057qib7 16344 22 +15 +15 CD cord-005453-4057qib7 16344 23 despite despite IN cord-005453-4057qib7 16344 24 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 16344 25 treatment treatment NN cord-005453-4057qib7 16344 26 ( ( -LRB- cord-005453-4057qib7 16344 27 n=1 n=1 FW cord-005453-4057qib7 16344 28 ) ) -RRB- cord-005453-4057qib7 16344 29 and and CC cord-005453-4057qib7 16344 30 complicated complicated JJ cord-005453-4057qib7 16344 31 cerebral cerebral JJ cord-005453-4057qib7 16344 32 seizures seizure NNS cord-005453-4057qib7 16344 33 followed follow VBN cord-005453-4057qib7 16344 34 by by IN cord-005453-4057qib7 16344 35 lung lung NN cord-005453-4057qib7 16344 36 haemorrhage haemorrhage NN cord-005453-4057qib7 16344 37 , , , cord-005453-4057qib7 16344 38 possibly possibly RB cord-005453-4057qib7 16344 39 due due IN cord-005453-4057qib7 16344 40 to to IN cord-005453-4057qib7 16344 41 aspiration aspiration NN cord-005453-4057qib7 16344 42 pneumonia pneumonia NN cord-005453-4057qib7 16344 43 with with IN cord-005453-4057qib7 16344 44 evidence evidence NN cord-005453-4057qib7 16344 45 of of IN cord-005453-4057qib7 16344 46 Enterococcus Enterococcus NNP cord-005453-4057qib7 16344 47 faecium faecium NN cord-005453-4057qib7 16344 48 , , , cord-005453-4057qib7 16344 49 resulting result VBG cord-005453-4057qib7 16344 50 in in IN cord-005453-4057qib7 16344 51 septic septic JJ cord-005453-4057qib7 16344 52 multi multi JJ cord-005453-4057qib7 16344 53 - - JJ cord-005453-4057qib7 16344 54 organ organ JJ cord-005453-4057qib7 16344 55 failure failure NN cord-005453-4057qib7 16344 56 on on IN cord-005453-4057qib7 16344 57 day day NN cord-005453-4057qib7 16344 58 +4 +4 NFP cord-005453-4057qib7 16344 59 ( ( -LRB- cord-005453-4057qib7 16344 60 n=1 n=1 FW cord-005453-4057qib7 16344 61 ) ) -RRB- cord-005453-4057qib7 16344 62 . . . cord-005453-4057qib7 16345 1 A a DT cord-005453-4057qib7 16345 2 third third JJ cord-005453-4057qib7 16345 3 HLH HLH NNP cord-005453-4057qib7 16345 4 patient patient NN cord-005453-4057qib7 16345 5 developed develop VBD cord-005453-4057qib7 16345 6 a a DT cord-005453-4057qib7 16345 7 sudden sudden JJ cord-005453-4057qib7 16345 8 cerebral cerebral JJ cord-005453-4057qib7 16345 9 edema edema NN cord-005453-4057qib7 16345 10 and and CC cord-005453-4057qib7 16345 11 ensuing ensue VBG cord-005453-4057qib7 16345 12 respiratory respiratory JJ cord-005453-4057qib7 16345 13 insufficiency insufficiency NN cord-005453-4057qib7 16345 14 on on IN cord-005453-4057qib7 16345 15 day day NN cord-005453-4057qib7 16345 16 +4 +4 NN cord-005453-4057qib7 16345 17 . . . cord-005453-4057qib7 16346 1 Whether whether IN cord-005453-4057qib7 16346 2 this this DT cord-005453-4057qib7 16346 3 was be VBD cord-005453-4057qib7 16346 4 caused cause VBN cord-005453-4057qib7 16346 5 by by IN cord-005453-4057qib7 16346 6 acute acute JJ cord-005453-4057qib7 16346 7 neurotoxic neurotoxic JJ cord-005453-4057qib7 16346 8 damage damage NN cord-005453-4057qib7 16346 9 by by IN cord-005453-4057qib7 16346 10 fludarabine fludarabine NN cord-005453-4057qib7 16346 11 or or CC cord-005453-4057qib7 16346 12 a a DT cord-005453-4057qib7 16346 13 consequence consequence NN cord-005453-4057qib7 16346 14 of of IN cord-005453-4057qib7 16346 15 relapsed relapse VBN cord-005453-4057qib7 16346 16 HLH HLH NNP cord-005453-4057qib7 16346 17 could could MD cord-005453-4057qib7 16346 18 not not RB cord-005453-4057qib7 16346 19 be be VB cord-005453-4057qib7 16346 20 conclusively conclusively RB cord-005453-4057qib7 16346 21 specified specify VBN cord-005453-4057qib7 16346 22 . . . cord-005453-4057qib7 16347 1 None none NN cord-005453-4057qib7 16347 2 of of IN cord-005453-4057qib7 16347 3 our -PRON- PRP$ cord-005453-4057qib7 16347 4 patients patient NNS cord-005453-4057qib7 16347 5 suffered suffer VBD cord-005453-4057qib7 16347 6 from from IN cord-005453-4057qib7 16347 7 transplant transplant NN cord-005453-4057qib7 16347 8 failure failure NN cord-005453-4057qib7 16347 9 or or CC cord-005453-4057qib7 16347 10 nonengraftment nonengraftment NN cord-005453-4057qib7 16347 11 . . . cord-005453-4057qib7 16348 1 There there EX cord-005453-4057qib7 16348 2 was be VBD cord-005453-4057qib7 16348 3 neither neither CC cord-005453-4057qib7 16348 4 severe severe JJ cord-005453-4057qib7 16348 5 acute acute JJ cord-005453-4057qib7 16348 6 GVHD GVHD NNP cord-005453-4057qib7 16348 7 ( ( -LRB- cord-005453-4057qib7 16348 8 III III NNP cord-005453-4057qib7 16348 9 - - HYPH cord-005453-4057qib7 16348 10 IV IV NNP cord-005453-4057qib7 16348 11 ) ) -RRB- cord-005453-4057qib7 16348 12 nor nor CC cord-005453-4057qib7 16348 13 chronic chronic JJ cord-005453-4057qib7 16348 14 GVHD GVHD NNP cord-005453-4057qib7 16348 15 observed observe VBD cord-005453-4057qib7 16348 16 in in IN cord-005453-4057qib7 16348 17 this this DT cord-005453-4057qib7 16348 18 cohort cohort NN cord-005453-4057qib7 16348 19 . . . cord-005453-4057qib7 16349 1 Conclusions conclusion NNS cord-005453-4057qib7 16349 2 : : : cord-005453-4057qib7 16349 3 Primary primary JJ cord-005453-4057qib7 16349 4 HLH HLH NNP cord-005453-4057qib7 16349 5 and and CC cord-005453-4057qib7 16349 6 high high JJ cord-005453-4057qib7 16349 7 - - HYPH cord-005453-4057qib7 16349 8 risk risk NN cord-005453-4057qib7 16349 9 LCH LCH NNP cord-005453-4057qib7 16349 10 are be VBP cord-005453-4057qib7 16349 11 lifethreatening lifethreatene VBG cord-005453-4057qib7 16349 12 medical medical JJ cord-005453-4057qib7 16349 13 conditions condition NNS cord-005453-4057qib7 16349 14 needing need VBG cord-005453-4057qib7 16349 15 rapid rapid JJ cord-005453-4057qib7 16349 16 alloHSCT alloHSCT NNP cord-005453-4057qib7 16349 17 . . . cord-005453-4057qib7 16350 1 RIC RIC NNP cord-005453-4057qib7 16350 2 regimens regimen NNS cord-005453-4057qib7 16350 3 are be VBP cord-005453-4057qib7 16350 4 well well RB cord-005453-4057qib7 16350 5 - - HYPH cord-005453-4057qib7 16350 6 tolerated tolerate VBN cord-005453-4057qib7 16350 7 and and CC cord-005453-4057qib7 16350 8 sufficient sufficient JJ cord-005453-4057qib7 16350 9 for for IN cord-005453-4057qib7 16350 10 proper proper JJ cord-005453-4057qib7 16350 11 engraftment engraftment NN cord-005453-4057qib7 16350 12 and and CC cord-005453-4057qib7 16350 13 disease disease NN cord-005453-4057qib7 16350 14 clearance clearance NN cord-005453-4057qib7 16350 15 . . . cord-005453-4057qib7 16351 1 Disclosure disclosure NN cord-005453-4057qib7 16351 2 : : : cord-005453-4057qib7 16352 1 The the DT cord-005453-4057qib7 16352 2 authors author NNS cord-005453-4057qib7 16352 3 have have VBP cord-005453-4057qib7 16352 4 no no DT cord-005453-4057qib7 16352 5 conflicts conflict NNS cord-005453-4057qib7 16352 6 of of IN cord-005453-4057qib7 16352 7 interest interest NN cord-005453-4057qib7 16352 8 to to TO cord-005453-4057qib7 16352 9 disclose disclose VB cord-005453-4057qib7 16352 10 . . . cord-005453-4057qib7 16353 1 Abstract Abstract NNP cord-005453-4057qib7 16353 2 withdrawn withdraw VBN cord-005453-4057qib7 16353 3 . . . cord-005453-4057qib7 16354 1 thrombocytopenia thrombocytopenia NNP cord-005453-4057qib7 16354 2 following follow VBG cord-005453-4057qib7 16355 1 allo allo NNP cord-005453-4057qib7 16355 2 - - HYPH cord-005453-4057qib7 16355 3 SCT sct NN cord-005453-4057qib7 16355 4 concomitant concomitant NN cord-005453-4057qib7 16355 5 to to IN cord-005453-4057qib7 16355 6 stem stem NN cord-005453-4057qib7 16355 7 cell cell NN cord-005453-4057qib7 16355 8 boosts boost NNS cord-005453-4057qib7 16355 9 . . . cord-005453-4057qib7 16356 1 Steroid steroid JJ cord-005453-4057qib7 16356 2 refractoriness refractoriness NN cord-005453-4057qib7 16356 3 was be VBD cord-005453-4057qib7 16356 4 defined define VBN cord-005453-4057qib7 16356 5 as as IN cord-005453-4057qib7 16356 6 : : : cord-005453-4057qib7 16356 7 progression progression NN cord-005453-4057qib7 16356 8 after after IN cord-005453-4057qib7 16356 9 three three CD cord-005453-4057qib7 16356 10 days day NNS cord-005453-4057qib7 16356 11 or or CC cord-005453-4057qib7 16356 12 no no DT cord-005453-4057qib7 16356 13 response response NN cord-005453-4057qib7 16356 14 after after IN cord-005453-4057qib7 16356 15 5 5 CD cord-005453-4057qib7 16356 16 days day NNS cord-005453-4057qib7 16356 17 of of IN cord-005453-4057qib7 16356 18 steroid steroid NN cord-005453-4057qib7 16356 19 treatment treatment NN cord-005453-4057qib7 16356 20 . . . cord-005453-4057qib7 16357 1 The the DT cord-005453-4057qib7 16357 2 median median JJ cord-005453-4057qib7 16357 3 time time NN cord-005453-4057qib7 16357 4 from from IN cord-005453-4057qib7 16357 5 SCT SCT NNP cord-005453-4057qib7 16357 6 to to IN cord-005453-4057qib7 16357 7 the the DT cord-005453-4057qib7 16357 8 onset onset NN cord-005453-4057qib7 16357 9 of of IN cord-005453-4057qib7 16357 10 aGvHD agvhd NN cord-005453-4057qib7 16357 11 was be VBD cord-005453-4057qib7 16357 12 22.5 22.5 CD cord-005453-4057qib7 16357 13 d d NN cord-005453-4057qib7 16357 14 ( ( -LRB- cord-005453-4057qib7 16357 15 range range NNP cord-005453-4057qib7 16357 16 9 9 CD cord-005453-4057qib7 16357 17 - - SYM cord-005453-4057qib7 16357 18 122 122 CD cord-005453-4057qib7 16357 19 d d NN cord-005453-4057qib7 16357 20 ) ) -RRB- cord-005453-4057qib7 16357 21 , , , cord-005453-4057qib7 16357 22 and and CC cord-005453-4057qib7 16357 23 11 11 CD cord-005453-4057qib7 16357 24 d d XX cord-005453-4057qib7 16357 25 ( ( -LRB- cord-005453-4057qib7 16357 26 range range NNP cord-005453-4057qib7 16357 27 3 3 CD cord-005453-4057qib7 16357 28 - - SYM cord-005453-4057qib7 16357 29 40 40 CD cord-005453-4057qib7 16357 30 d d NN cord-005453-4057qib7 16357 31 ) ) -RRB- cord-005453-4057qib7 16357 32 from from IN cord-005453-4057qib7 16357 33 the the DT cord-005453-4057qib7 16357 34 onset onset NN cord-005453-4057qib7 16357 35 of of IN cord-005453-4057qib7 16357 36 aGvHD agvhd NN cord-005453-4057qib7 16357 37 to to IN cord-005453-4057qib7 16357 38 the the DT cord-005453-4057qib7 16357 39 first first JJ cord-005453-4057qib7 16357 40 MSC MSC NNP cord-005453-4057qib7 16357 41 infusion infusion NN cord-005453-4057qib7 16357 42 , , , cord-005453-4057qib7 16357 43 respectively respectively RB cord-005453-4057qib7 16357 44 . . . cord-005453-4057qib7 16358 1 The the DT cord-005453-4057qib7 16358 2 majority majority NN cord-005453-4057qib7 16358 3 of of IN cord-005453-4057qib7 16358 4 our -PRON- PRP$ cord-005453-4057qib7 16358 5 patients patient NNS cord-005453-4057qib7 16358 6 ( ( -LRB- cord-005453-4057qib7 16358 7 n=5 n=5 RB cord-005453-4057qib7 16358 8 ) ) -RRB- cord-005453-4057qib7 16358 9 suffered suffer VBD cord-005453-4057qib7 16358 10 from from IN cord-005453-4057qib7 16358 11 a a DT cord-005453-4057qib7 16358 12 malignant malignant JJ cord-005453-4057qib7 16358 13 disease disease NN cord-005453-4057qib7 16358 14 and and CC cord-005453-4057qib7 16358 15 received receive VBD cord-005453-4057qib7 16358 16 a a DT cord-005453-4057qib7 16358 17 graft graft NN cord-005453-4057qib7 16358 18 from from IN cord-005453-4057qib7 16358 19 a a DT cord-005453-4057qib7 16358 20 matched match VBN cord-005453-4057qib7 16358 21 unrelated unrelated JJ cord-005453-4057qib7 16358 22 donor donor NN cord-005453-4057qib7 16358 23 ( ( -LRB- cord-005453-4057qib7 16358 24 n=6 n=6 NNP cord-005453-4057qib7 16358 25 ) ) -RRB- cord-005453-4057qib7 16358 26 , , , cord-005453-4057qib7 16358 27 while while IN cord-005453-4057qib7 16358 28 one one CD cord-005453-4057qib7 16358 29 patient patient NN cord-005453-4057qib7 16358 30 had have VBD cord-005453-4057qib7 16358 31 a a DT cord-005453-4057qib7 16358 32 haploidentical haploidentical JJ cord-005453-4057qib7 16358 33 donor donor NN cord-005453-4057qib7 16358 34 . . . cord-005453-4057qib7 16359 1 GvHD GvHD NNP cord-005453-4057qib7 16359 2 prophylaxis prophylaxis NN cord-005453-4057qib7 16359 3 was be VBD cord-005453-4057qib7 16359 4 performed perform VBN cord-005453-4057qib7 16359 5 in in IN cord-005453-4057qib7 16359 6 all all DT cord-005453-4057qib7 16359 7 patients patient NNS cord-005453-4057qib7 16359 8 except except IN cord-005453-4057qib7 16359 9 the the DT cord-005453-4057qib7 16359 10 patient patient NN cord-005453-4057qib7 16359 11 with with IN cord-005453-4057qib7 16359 12 the the DT cord-005453-4057qib7 16359 13 haplo haplo NN cord-005453-4057qib7 16359 14 - - HYPH cord-005453-4057qib7 16359 15 identical identical JJ cord-005453-4057qib7 16359 16 graft graft NN cord-005453-4057qib7 16359 17 . . . cord-005453-4057qib7 16360 1 All all DT cord-005453-4057qib7 16360 2 patients patient NNS cord-005453-4057qib7 16360 3 with with IN cord-005453-4057qib7 16360 4 aGvHD aGvHD NNS cord-005453-4057qib7 16360 5 were be VBD cord-005453-4057qib7 16360 6 treated treat VBN cord-005453-4057qib7 16360 7 with with IN cord-005453-4057qib7 16360 8 steroids steroid NNS cord-005453-4057qib7 16360 9 and and CC cord-005453-4057qib7 16360 10 the the DT cord-005453-4057qib7 16360 11 patient patient NN cord-005453-4057qib7 16360 12 with with IN cord-005453-4057qib7 16360 13 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 16360 14 required require VBN cord-005453-4057qib7 16360 15 regularly regularly RB cord-005453-4057qib7 16360 16 transfusions transfusion NNS cord-005453-4057qib7 16360 17 and and CC cord-005453-4057qib7 16360 18 Romiplostin Romiplostin NNP cord-005453-4057qib7 16360 19 therapy therapy NN cord-005453-4057qib7 16360 20 . . . cord-005453-4057qib7 16361 1 The the DT cord-005453-4057qib7 16361 2 median median JJ cord-005453-4057qib7 16361 3 MSC MSC NNP cord-005453-4057qib7 16361 4 dose dose NN cord-005453-4057qib7 16361 5 was be VBD cord-005453-4057qib7 16361 6 1.7x10 1.7x10 CD cord-005453-4057qib7 16361 7 6 6 CD cord-005453-4057qib7 16361 8 cells cell NNS cord-005453-4057qib7 16361 9 / / SYM cord-005453-4057qib7 16361 10 kg kg NN cord-005453-4057qib7 16361 11 BW BW NNP cord-005453-4057qib7 16361 12 ( ( -LRB- cord-005453-4057qib7 16361 13 minimum minimum JJ cord-005453-4057qib7 16361 14 1.1 1.1 CD cord-005453-4057qib7 16361 15 x10 x10 CD cord-005453-4057qib7 16361 16 6 6 CD cord-005453-4057qib7 16361 17 ; ; : cord-005453-4057qib7 16361 18 maximum maximum JJ cord-005453-4057qib7 16361 19 3 3 CD cord-005453-4057qib7 16361 20 x10 x10 CD cord-005453-4057qib7 16361 21 6 6 CD cord-005453-4057qib7 16361 22 ) ) -RRB- cord-005453-4057qib7 16361 23 . . . cord-005453-4057qib7 16362 1 Three three CD cord-005453-4057qib7 16362 2 patients patient NNS cord-005453-4057qib7 16362 3 received receive VBD cord-005453-4057qib7 16362 4 2 2 CD cord-005453-4057qib7 16362 5 MSC MSC NNP cord-005453-4057qib7 16362 6 doses dose NNS cord-005453-4057qib7 16362 7 , , , cord-005453-4057qib7 16362 8 two two CD cord-005453-4057qib7 16362 9 patients patient NNS cord-005453-4057qib7 16362 10 4 4 CD cord-005453-4057qib7 16362 11 , , , cord-005453-4057qib7 16362 12 one one CD cord-005453-4057qib7 16362 13 patient patient NN cord-005453-4057qib7 16362 14 5 5 CD cord-005453-4057qib7 16362 15 and and CC cord-005453-4057qib7 16362 16 another another DT cord-005453-4057qib7 16362 17 7 7 CD cord-005453-4057qib7 16362 18 doses dose NNS cord-005453-4057qib7 16362 19 . . . cord-005453-4057qib7 16363 1 Results result NNS cord-005453-4057qib7 16363 2 : : : cord-005453-4057qib7 16364 1 At at IN cord-005453-4057qib7 16364 2 the the DT cord-005453-4057qib7 16364 3 time time NN cord-005453-4057qib7 16364 4 point point NN cord-005453-4057qib7 16364 5 of of IN cord-005453-4057qib7 16364 6 aGvHD agvhd NN cord-005453-4057qib7 16364 7 manifestation manifestation NNP cord-005453-4057qib7 16364 8 and and CC cord-005453-4057qib7 16364 9 MSC MSC NNP cord-005453-4057qib7 16364 10 application application NN cord-005453-4057qib7 16364 11 , , , cord-005453-4057qib7 16364 12 two two CD cord-005453-4057qib7 16364 13 patients patient NNS cord-005453-4057qib7 16364 14 had have VBD cord-005453-4057qib7 16364 15 CMV CMV NNP cord-005453-4057qib7 16364 16 reactivation reactivation NN cord-005453-4057qib7 16364 17 , , , cord-005453-4057qib7 16364 18 one one CD cord-005453-4057qib7 16364 19 patient patient NN cord-005453-4057qib7 16364 20 adenovirus adenovirus NN cord-005453-4057qib7 16364 21 infection infection NN cord-005453-4057qib7 16364 22 and and CC cord-005453-4057qib7 16364 23 one one CD cord-005453-4057qib7 16364 24 patient patient JJ cord-005453-4057qib7 16364 25 EBVreactivation ebvreactivation NN cord-005453-4057qib7 16364 26 . . . cord-005453-4057qib7 16365 1 By by IN cord-005453-4057qib7 16365 2 day day NN cord-005453-4057qib7 16365 3 28 28 CD cord-005453-4057qib7 16365 4 , , , cord-005453-4057qib7 16365 5 5/6 5/6 CD cord-005453-4057qib7 16365 6 aGvHD agvhd NN cord-005453-4057qib7 16365 7 patients patient NNS cord-005453-4057qib7 16365 8 responded respond VBD cord-005453-4057qib7 16365 9 to to IN cord-005453-4057qib7 16365 10 MSC MSC NNP cord-005453-4057qib7 16365 11 administration administration NN cord-005453-4057qib7 16365 12 : : : cord-005453-4057qib7 16365 13 3 3 CD cord-005453-4057qib7 16365 14 with with IN cord-005453-4057qib7 16365 15 complete complete JJ cord-005453-4057qib7 16365 16 response response NN cord-005453-4057qib7 16365 17 and and CC cord-005453-4057qib7 16365 18 2 2 CD cord-005453-4057qib7 16365 19 with with IN cord-005453-4057qib7 16365 20 partial partial JJ cord-005453-4057qib7 16365 21 response response NN cord-005453-4057qib7 16365 22 . . . cord-005453-4057qib7 16366 1 At at IN cord-005453-4057qib7 16366 2 the the DT cord-005453-4057qib7 16366 3 last last JJ cord-005453-4057qib7 16366 4 follow follow NN cord-005453-4057qib7 16366 5 - - HYPH cord-005453-4057qib7 16366 6 up up NN cord-005453-4057qib7 16366 7 ( ( -LRB- cord-005453-4057qib7 16366 8 median median NN cord-005453-4057qib7 16366 9 : : : cord-005453-4057qib7 16366 10 4.42 4.42 CD cord-005453-4057qib7 16366 11 months month NNS cord-005453-4057qib7 16366 12 , , , cord-005453-4057qib7 16366 13 range range VBP cord-005453-4057qib7 16366 14 0,82 0,82 CD cord-005453-4057qib7 16366 15 - - HYPH cord-005453-4057qib7 16366 16 12.06 12.06 CD cord-005453-4057qib7 16366 17 months month NNS cord-005453-4057qib7 16366 18 ) ) -RRB- cord-005453-4057qib7 16366 19 , , , cord-005453-4057qib7 16366 20 4 4 CD cord-005453-4057qib7 16366 21 of of IN cord-005453-4057qib7 16366 22 6 6 CD cord-005453-4057qib7 16366 23 patients patient NNS cord-005453-4057qib7 16366 24 were be VBD cord-005453-4057qib7 16366 25 alive alive JJ cord-005453-4057qib7 16366 26 without without IN cord-005453-4057qib7 16366 27 acute acute JJ cord-005453-4057qib7 16366 28 or or CC cord-005453-4057qib7 16366 29 chronic chronic JJ cord-005453-4057qib7 16366 30 GVHD GVHD NNP cord-005453-4057qib7 16366 31 . . . cord-005453-4057qib7 16367 1 One one CD cord-005453-4057qib7 16367 2 patient patient NN cord-005453-4057qib7 16367 3 died die VBD cord-005453-4057qib7 16367 4 soon soon RB cord-005453-4057qib7 16367 5 after after IN cord-005453-4057qib7 16367 6 MSC MSC NNP cord-005453-4057qib7 16367 7 treatment treatment NN cord-005453-4057qib7 16367 8 with with IN cord-005453-4057qib7 16367 9 no no DT cord-005453-4057qib7 16367 10 obvious obvious JJ cord-005453-4057qib7 16367 11 response response NN cord-005453-4057qib7 16367 12 in in IN cord-005453-4057qib7 16367 13 the the DT cord-005453-4057qib7 16367 14 course course NN cord-005453-4057qib7 16367 15 of of IN cord-005453-4057qib7 16367 16 a a DT cord-005453-4057qib7 16367 17 systemic systemic JJ cord-005453-4057qib7 16367 18 hyperinflammation hyperinflammation NN cord-005453-4057qib7 16367 19 syndrome syndrome NN cord-005453-4057qib7 16367 20 . . . cord-005453-4057qib7 16368 1 The the DT cord-005453-4057qib7 16368 2 other other JJ cord-005453-4057qib7 16368 3 patient patient NN cord-005453-4057qib7 16368 4 although although IN cord-005453-4057qib7 16368 5 complete complete JJ cord-005453-4057qib7 16368 6 responder responder NN cord-005453-4057qib7 16368 7 to to IN cord-005453-4057qib7 16368 8 MSC MSC NNP cord-005453-4057qib7 16368 9 - - HYPH cord-005453-4057qib7 16368 10 FFM FFM NNP cord-005453-4057qib7 16368 11 developed develop VBD cord-005453-4057qib7 16368 12 fatal fatal JJ cord-005453-4057qib7 16368 13 adenovirus adenovirus NN cord-005453-4057qib7 16368 14 sepsis sepsis NN cord-005453-4057qib7 16368 15 . . . cord-005453-4057qib7 16369 1 This this DT cord-005453-4057qib7 16369 2 based base VBN cord-005453-4057qib7 16369 3 on on IN cord-005453-4057qib7 16369 4 the the DT cord-005453-4057qib7 16369 5 profound profound JJ cord-005453-4057qib7 16369 6 Tcell Tcell NNP cord-005453-4057qib7 16369 7 depletion depletion NN cord-005453-4057qib7 16369 8 induced induce VBN cord-005453-4057qib7 16369 9 by by IN cord-005453-4057qib7 16369 10 concomitant concomitant JJ cord-005453-4057qib7 16369 11 application application NN cord-005453-4057qib7 16369 12 of of IN cord-005453-4057qib7 16369 13 steroids steroid NNS cord-005453-4057qib7 16369 14 . . . cord-005453-4057qib7 16370 1 The the DT cord-005453-4057qib7 16370 2 overall overall JJ cord-005453-4057qib7 16370 3 survival survival NN cord-005453-4057qib7 16370 4 probability probability NN cord-005453-4057qib7 16370 5 at at IN cord-005453-4057qib7 16370 6 six six CD cord-005453-4057qib7 16370 7 month month NN cord-005453-4057qib7 16370 8 was be VBD cord-005453-4057qib7 16370 9 66.7 66.7 CD cord-005453-4057qib7 16370 10 % % NN cord-005453-4057qib7 16370 11 . . . cord-005453-4057qib7 16371 1 No no DT cord-005453-4057qib7 16371 2 acute acute JJ cord-005453-4057qib7 16371 3 side side NN cord-005453-4057qib7 16371 4 effects effect NNS cord-005453-4057qib7 16371 5 occurred occur VBD cord-005453-4057qib7 16371 6 after after IN cord-005453-4057qib7 16371 7 MSC MSC NNP cord-005453-4057qib7 16371 8 infusions infusion NNS cord-005453-4057qib7 16371 9 . . . cord-005453-4057qib7 16372 1 The the DT cord-005453-4057qib7 16372 2 previously previously RB cord-005453-4057qib7 16372 3 mentioned mention VBN cord-005453-4057qib7 16372 4 patient patient JJ cord-005453-4057qib7 16372 5 suffering suffer VBG cord-005453-4057qib7 16372 6 from from IN cord-005453-4057qib7 16372 7 thrombocytopenia thrombocytopenia NN cord-005453-4057qib7 16372 8 did do VBD cord-005453-4057qib7 16372 9 not not RB cord-005453-4057qib7 16372 10 need need VB cord-005453-4057qib7 16372 11 any any DT cord-005453-4057qib7 16372 12 further further JJ cord-005453-4057qib7 16372 13 transfusions transfusion NNS cord-005453-4057qib7 16372 14 after after IN cord-005453-4057qib7 16372 15 receiving receive VBG cord-005453-4057qib7 16372 16 2 2 CD cord-005453-4057qib7 16372 17 doses dose NNS cord-005453-4057qib7 16372 18 MSCs msc NNS cord-005453-4057qib7 16372 19 combined combine VBN cord-005453-4057qib7 16372 20 with with IN cord-005453-4057qib7 16372 21 stem stem NN cord-005453-4057qib7 16372 22 cell cell NN cord-005453-4057qib7 16372 23 boosts boost NNS cord-005453-4057qib7 16372 24 while while IN cord-005453-4057qib7 16372 25 continuing continue VBG cord-005453-4057qib7 16372 26 Romiplostin Romiplostin NNP cord-005453-4057qib7 16372 27 application application NN cord-005453-4057qib7 16372 28 . . . cord-005453-4057qib7 16373 1 Conclusions conclusion NNS cord-005453-4057qib7 16373 2 : : : cord-005453-4057qib7 16374 1 Our -PRON- PRP$ cord-005453-4057qib7 16374 2 data datum NNS cord-005453-4057qib7 16374 3 confirm confirm VBP cord-005453-4057qib7 16374 4 excellent excellent JJ cord-005453-4057qib7 16374 5 tolerability tolerability NN cord-005453-4057qib7 16374 6 and and CC cord-005453-4057qib7 16374 7 high high JJ cord-005453-4057qib7 16374 8 efficacy efficacy NN cord-005453-4057qib7 16374 9 of of IN cord-005453-4057qib7 16374 10 the the DT cord-005453-4057qib7 16374 11 licensed licensed JJ cord-005453-4057qib7 16374 12 off off IN cord-005453-4057qib7 16374 13 - - HYPH cord-005453-4057qib7 16374 14 the the DT cord-005453-4057qib7 16374 15 - - HYPH cord-005453-4057qib7 16374 16 shelf shelf NN cord-005453-4057qib7 16374 17 MSC MSC NNP cord-005453-4057qib7 16374 18 preparation preparation NN cord-005453-4057qib7 16374 19 " " `` cord-005453-4057qib7 16374 20 MSC MSC NNP cord-005453-4057qib7 16374 21 - - HYPH cord-005453-4057qib7 16374 22 FFM FFM NNP cord-005453-4057qib7 16374 23 " " '' cord-005453-4057qib7 16374 24 in in IN cord-005453-4057qib7 16374 25 pediatric pediatric JJ cord-005453-4057qib7 16374 26 steroid steroid JJ cord-005453-4057qib7 16374 27 - - HYPH cord-005453-4057qib7 16374 28 refractory refractory JJ cord-005453-4057qib7 16374 29 aGvHD agvhd NN cord-005453-4057qib7 16374 30 . . . cord-005453-4057qib7 16375 1 In in IN cord-005453-4057qib7 16375 2 our -PRON- PRP$ cord-005453-4057qib7 16375 3 center center NN cord-005453-4057qib7 16375 4 , , , cord-005453-4057qib7 16375 5 current current JJ cord-005453-4057qib7 16375 6 treatment treatment NN cord-005453-4057qib7 16375 7 algorithms algorithm NNS cord-005453-4057qib7 16375 8 have have VBP cord-005453-4057qib7 16375 9 escalated escalate VBN cord-005453-4057qib7 16375 10 " " `` cord-005453-4057qib7 16375 11 MSC MSC NNP cord-005453-4057qib7 16375 12 - - HYPH cord-005453-4057qib7 16375 13 FFM FFM NNP cord-005453-4057qib7 16375 14 " " '' cord-005453-4057qib7 16375 15 to to IN cord-005453-4057qib7 16375 16 the the DT cord-005453-4057qib7 16375 17 second second JJ cord-005453-4057qib7 16375 18 line line NN cord-005453-4057qib7 16375 19 , , , cord-005453-4057qib7 16375 20 i.e. i.e. FW cord-005453-4057qib7 16375 21 immediately immediately RB cord-005453-4057qib7 16375 22 after after IN cord-005453-4057qib7 16375 23 steroid steroid NN cord-005453-4057qib7 16375 24 refractoriness refractoriness NN cord-005453-4057qib7 16375 25 has have VBZ cord-005453-4057qib7 16375 26 been be VBN cord-005453-4057qib7 16375 27 established establish VBN cord-005453-4057qib7 16375 28 . . . cord-005453-4057qib7 16376 1 Besides besides IN cord-005453-4057qib7 16376 2 immunoregulatory immunoregulatory JJ cord-005453-4057qib7 16376 3 properties property NNS cord-005453-4057qib7 16376 4 , , , cord-005453-4057qib7 16376 5 this this DT cord-005453-4057qib7 16376 6 product product NN cord-005453-4057qib7 16376 7 might may MD cord-005453-4057qib7 16376 8 facilitate facilitate VB cord-005453-4057qib7 16376 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 16376 10 stem stem NN cord-005453-4057qib7 16376 11 cell cell NN cord-005453-4057qib7 16376 12 engraftment engraftment NN cord-005453-4057qib7 16376 13 . . . cord-005453-4057qib7 16377 1 Disclosure disclosure NN cord-005453-4057qib7 16377 2 : : : cord-005453-4057qib7 16378 1 Novartis Novartis NNP cord-005453-4057qib7 16378 2 ( ( -LRB- cord-005453-4057qib7 16378 3 consultancy consultancy NN cord-005453-4057qib7 16378 4 : : : cord-005453-4057qib7 16378 5 included include VBN cord-005453-4057qib7 16378 6 expert expert JJ cord-005453-4057qib7 16378 7 testimony testimony NN cord-005453-4057qib7 16378 8 , , , cord-005453-4057qib7 16378 9 speaker speaker NNP cord-005453-4057qib7 16378 10 bureau bureau NNP cord-005453-4057qib7 16378 11 , , , cord-005453-4057qib7 16378 12 Honoraria Honoraria NNP cord-005453-4057qib7 16378 13 ) ) -RRB- cord-005453-4057qib7 16378 14 , , , cord-005453-4057qib7 16378 15 Medac Medac NNP cord-005453-4057qib7 16378 16 ( ( -LRB- cord-005453-4057qib7 16378 17 Research Research NNP cord-005453-4057qib7 16378 18 Funding Funding NNP cord-005453-4057qib7 16378 19 , , , cord-005453-4057qib7 16378 20 Patents Patents NNPS cord-005453-4057qib7 16378 21 and and CC cord-005453-4057qib7 16378 22 Royalties Royalties NNPS cord-005453-4057qib7 16378 23 ) ) -RRB- cord-005453-4057qib7 16378 24 , , , cord-005453-4057qib7 16378 25 Riemser Riemser NNP cord-005453-4057qib7 16378 26 ( ( -LRB- cord-005453-4057qib7 16378 27 Research Research NNP cord-005453-4057qib7 16378 28 Funding Funding NNP cord-005453-4057qib7 16378 29 ) ) -RRB- cord-005453-4057qib7 16378 30 , , , cord-005453-4057qib7 16378 31 Neovii Neovii NNP cord-005453-4057qib7 16378 32 ( ( -LRB- cord-005453-4057qib7 16378 33 Research Research NNP cord-005453-4057qib7 16378 34 Funding Funding NNP cord-005453-4057qib7 16378 35 ) ) -RRB- cord-005453-4057qib7 16378 36 , , , cord-005453-4057qib7 16378 37 Amgen Amgen NNP cord-005453-4057qib7 16378 38 ( ( -LRB- cord-005453-4057qib7 16378 39 Honoraria Honoraria NNP cord-005453-4057qib7 16378 40 ) ) -RRB- cord-005453-4057qib7 16378 41 Expression expression NN cord-005453-4057qib7 16378 42 of of IN cord-005453-4057qib7 16378 43 CCR4 CCR4 NNP cord-005453-4057qib7 16378 44 modulates modulate VBZ cord-005453-4057qib7 16378 45 migrational migrational JJ cord-005453-4057qib7 16378 46 properties property NNS cord-005453-4057qib7 16378 47 of of IN cord-005453-4057qib7 16378 48 in in FW cord-005453-4057qib7 16378 49 vitro vitro FW cord-005453-4057qib7 16378 50 expanded expand VBN cord-005453-4057qib7 16378 51 murine murine JJ cord-005453-4057qib7 16378 52 regulatory regulatory JJ cord-005453-4057qib7 16378 53 t t NN cord-005453-4057qib7 16378 54 cells cell NNS cord-005453-4057qib7 16378 55 Laura Laura NNP cord-005453-4057qib7 16378 56 M. M. NNP cord-005453-4057qib7 16378 57 Moser Moser NNP cord-005453-4057qib7 16378 58 1,2 1,2 CD cord-005453-4057qib7 16378 59 , , , cord-005453-4057qib7 16378 60 Ulrike Ulrike NNP cord-005453-4057qib7 16378 61 Tischler Tischler NNP cord-005453-4057qib7 16378 62 1 1 CD cord-005453-4057qib7 16378 63 , , , cord-005453-4057qib7 16378 64 Christin Christin NNP cord-005453-4057qib7 16378 65 Riegel Riegel NNP cord-005453-4057qib7 16378 66 1 1 CD cord-005453-4057qib7 16378 67 , , , cord-005453-4057qib7 16378 68 Julia Julia NNP cord-005453-4057qib7 16378 69 Minderjahn Minderjahn NNP cord-005453-4057qib7 16378 70 1 1 CD cord-005453-4057qib7 16378 71 , , , cord-005453-4057qib7 16378 72 Rüdiger Rüdiger NNP cord-005453-4057qib7 16378 73 Eder Eder NNP cord-005453-4057qib7 16378 74 1 1 CD cord-005453-4057qib7 16378 75 , , , cord-005453-4057qib7 16378 76 Jaqueline Jaqueline NNP cord-005453-4057qib7 16378 77 Dirmeier Dirmeier NNP cord-005453-4057qib7 16378 78 1 1 CD cord-005453-4057qib7 16378 79 , , , cord-005453-4057qib7 16378 80 Isabel Isabel NNP cord-005453-4057qib7 16378 81 Zimmermann Zimmermann NNP cord-005453-4057qib7 16378 82 1 1 CD cord-005453-4057qib7 16378 83 , , , cord-005453-4057qib7 16378 84 Evelyn Evelyn NNP cord-005453-4057qib7 16378 85 Röseler Röseler NNP cord-005453-4057qib7 16378 86 1 1 CD cord-005453-4057qib7 16378 87 , , , cord-005453-4057qib7 16378 88 Petra Petra NNP cord-005453-4057qib7 16378 89 Hoffmann Hoffmann NNP cord-005453-4057qib7 16378 90 1,3 1,3 NNP cord-005453-4057qib7 16378 91 , , , cord-005453-4057qib7 16378 92 Matthias Matthias NNP cord-005453-4057qib7 16378 93 Edinger Edinger NNP cord-005453-4057qib7 16378 94 1 1 CD cord-005453-4057qib7 16378 95 , , , cord-005453-4057qib7 16379 1 3 3 CD cord-005453-4057qib7 16379 2 Background background NN cord-005453-4057qib7 16379 3 : : : cord-005453-4057qib7 16380 1 Hematopoietic hematopoietic JJ cord-005453-4057qib7 16380 2 stem stem NN cord-005453-4057qib7 16380 3 cell cell NN cord-005453-4057qib7 16380 4 transplantation transplantation NN cord-005453-4057qib7 16380 5 ( ( -LRB- cord-005453-4057qib7 16380 6 HSCT HSCT NNP cord-005453-4057qib7 16380 7 ) ) -RRB- cord-005453-4057qib7 16380 8 as as IN cord-005453-4057qib7 16380 9 it -PRON- PRP cord-005453-4057qib7 16380 10 is be VBZ cord-005453-4057qib7 16380 11 carried carry VBN cord-005453-4057qib7 16380 12 out out RP cord-005453-4057qib7 16380 13 successfully successfully RB cord-005453-4057qib7 16380 14 at at IN cord-005453-4057qib7 16380 15 other other JJ cord-005453-4057qib7 16380 16 genetic genetic JJ cord-005453-4057qib7 16380 17 instability instability NN cord-005453-4057qib7 16380 18 syndromes syndrome NNS cord-005453-4057qib7 16380 19 seems seem VBZ cord-005453-4057qib7 16380 20 to to TO cord-005453-4057qib7 16380 21 be be VB cord-005453-4057qib7 16380 22 an an DT cord-005453-4057qib7 16380 23 encouraging encouraging JJ cord-005453-4057qib7 16380 24 opportunity opportunity NN cord-005453-4057qib7 16380 25 for for IN cord-005453-4057qib7 16380 26 a a DT cord-005453-4057qib7 16380 27 curative curative JJ cord-005453-4057qib7 16380 28 therapy therapy NN cord-005453-4057qib7 16380 29 to to TO cord-005453-4057qib7 16380 30 restore restore VB cord-005453-4057qib7 16380 31 immunity immunity NN cord-005453-4057qib7 16380 32 and and CC cord-005453-4057qib7 16380 33 prevent prevent VB cord-005453-4057qib7 16380 34 the the DT cord-005453-4057qib7 16380 35 development development NN cord-005453-4057qib7 16380 36 of of IN cord-005453-4057qib7 16380 37 hematologic hematologic JJ cord-005453-4057qib7 16380 38 malignancies malignancy NNS cord-005453-4057qib7 16380 39 in in IN cord-005453-4057qib7 16380 40 Ataxiatelangiectasia Ataxiatelangiectasia NNP cord-005453-4057qib7 16380 41 ( ( -LRB- cord-005453-4057qib7 16380 42 A A NNP cord-005453-4057qib7 16380 43 - - HYPH cord-005453-4057qib7 16380 44 T T NNP cord-005453-4057qib7 16380 45 ) ) -RRB- cord-005453-4057qib7 16380 46 . . . cord-005453-4057qib7 16381 1 However however RB cord-005453-4057qib7 16381 2 , , , cord-005453-4057qib7 16381 3 experience experience NN cord-005453-4057qib7 16381 4 in in IN cord-005453-4057qib7 16381 5 the the DT cord-005453-4057qib7 16381 6 conditioning conditioning NN cord-005453-4057qib7 16381 7 regimen regimen NN cord-005453-4057qib7 16381 8 is be VBZ cord-005453-4057qib7 16381 9 limited limit VBN cord-005453-4057qib7 16381 10 and and CC cord-005453-4057qib7 16381 11 no no DT cord-005453-4057qib7 16381 12 transplantation transplantation NN cord-005453-4057qib7 16381 13 strategy strategy NN cord-005453-4057qib7 16381 14 for for IN cord-005453-4057qib7 16381 15 A A NNP cord-005453-4057qib7 16381 16 - - HYPH cord-005453-4057qib7 16381 17 T t NN cord-005453-4057qib7 16381 18 patients patient NNS cord-005453-4057qib7 16381 19 exists exist VBZ cord-005453-4057qib7 16381 20 , , , cord-005453-4057qib7 16381 21 especially especially RB cord-005453-4057qib7 16381 22 in in IN cord-005453-4057qib7 16381 23 an an DT cord-005453-4057qib7 16381 24 allogeneic allogeneic NN cord-005453-4057qib7 16381 25 setting setting NN cord-005453-4057qib7 16381 26 . . . cord-005453-4057qib7 16382 1 Conditioning conditioning NN cord-005453-4057qib7 16382 2 regimen regimen NN cord-005453-4057qib7 16382 3 and and CC cord-005453-4057qib7 16382 4 donor donor NN cord-005453-4057qib7 16382 5 selection selection NN cord-005453-4057qib7 16382 6 are be VBP cord-005453-4057qib7 16382 7 critical critical JJ cord-005453-4057qib7 16382 8 factors factor NNS cord-005453-4057qib7 16382 9 in in IN cord-005453-4057qib7 16382 10 the the DT cord-005453-4057qib7 16382 11 clinical clinical JJ cord-005453-4057qib7 16382 12 setting setting NN cord-005453-4057qib7 16382 13 of of IN cord-005453-4057qib7 16382 14 HSCT HSCT NNP cord-005453-4057qib7 16382 15 and and CC cord-005453-4057qib7 16382 16 incur incur VB cord-005453-4057qib7 16382 17 substantial substantial JJ cord-005453-4057qib7 16382 18 risks risk NNS cord-005453-4057qib7 16382 19 , , , cord-005453-4057qib7 16382 20 especially especially RB cord-005453-4057qib7 16382 21 in in IN cord-005453-4057qib7 16382 22 A a NN cord-005453-4057qib7 16382 23 - - HYPH cord-005453-4057qib7 16382 24 T. t. NN cord-005453-4057qib7 16383 1 The the DT cord-005453-4057qib7 16383 2 aim aim NN cord-005453-4057qib7 16383 3 of of IN cord-005453-4057qib7 16383 4 this this DT cord-005453-4057qib7 16383 5 study study NN cord-005453-4057qib7 16383 6 was be VBD cord-005453-4057qib7 16383 7 ( ( -LRB- cord-005453-4057qib7 16383 8 1 1 CD cord-005453-4057qib7 16383 9 ) ) -RRB- cord-005453-4057qib7 16383 10 to to TO cord-005453-4057qib7 16383 11 evaluate evaluate VB cord-005453-4057qib7 16383 12 whether whether IN cord-005453-4057qib7 16383 13 different different JJ cord-005453-4057qib7 16383 14 approaches approach NNS cord-005453-4057qib7 16383 15 of of IN cord-005453-4057qib7 16383 16 HSCT HSCT NNP cord-005453-4057qib7 16383 17 including include VBG cord-005453-4057qib7 16383 18 allogeneic allogeneic JJ cord-005453-4057qib7 16383 19 hematopoietic hematopoietic JJ cord-005453-4057qib7 16383 20 HSCT HSCT NNP cord-005453-4057qib7 16383 21 are be VBP cord-005453-4057qib7 16383 22 feasible feasible JJ cord-005453-4057qib7 16383 23 in in IN cord-005453-4057qib7 16383 24 regard regard NN cord-005453-4057qib7 16383 25 to to IN cord-005453-4057qib7 16383 26 graft graft NN cord-005453-4057qib7 16383 27 versus versus IN cord-005453-4057qib7 16383 28 host host NN cord-005453-4057qib7 16383 29 response response NN cord-005453-4057qib7 16383 30 ( ( -LRB- cord-005453-4057qib7 16383 31 GvHD GvHD NNP cord-005453-4057qib7 16383 32 ) ) -RRB- cord-005453-4057qib7 16383 33 and and CC cord-005453-4057qib7 16384 1 sufficient sufficient JJ cord-005453-4057qib7 16384 2 concerning concern VBG cord-005453-4057qib7 16384 3 immune immune JJ cord-005453-4057qib7 16384 4 reconstitution reconstitution NN cord-005453-4057qib7 16384 5 ( ( -LRB- cord-005453-4057qib7 16384 6 2 2 CD cord-005453-4057qib7 16384 7 ) ) -RRB- cord-005453-4057qib7 16384 8 and and CC cord-005453-4057qib7 16384 9 to to IN cord-005453-4057qib7 16384 10 de de FW cord-005453-4057qib7 16384 11 - - VB cord-005453-4057qib7 16384 12 escalate escalate VB cord-005453-4057qib7 16384 13 the the DT cord-005453-4057qib7 16384 14 toxic toxic JJ cord-005453-4057qib7 16384 15 effects effect NNS cord-005453-4057qib7 16384 16 of of IN cord-005453-4057qib7 16384 17 the the DT cord-005453-4057qib7 16384 18 conditioning conditioning NN cord-005453-4057qib7 16384 19 regimen regimen NN cord-005453-4057qib7 16384 20 by by IN cord-005453-4057qib7 16384 21 reducing reduce VBG cord-005453-4057qib7 16384 22 the the DT cord-005453-4057qib7 16384 23 dose dose NN cord-005453-4057qib7 16384 24 of of IN cord-005453-4057qib7 16384 25 cyclophosphamide cyclophosphamide NN cord-005453-4057qib7 16384 26 ( ( -LRB- cord-005453-4057qib7 16384 27 CP).Methods cp).method NNS cord-005453-4057qib7 16384 28 : : : cord-005453-4057qib7 16384 29 T t NN cord-005453-4057qib7 16384 30 cells cell NNS cord-005453-4057qib7 16384 31 from from IN cord-005453-4057qib7 16384 32 syngeneic syngeneic NNS cord-005453-4057qib7 16384 33 , , , cord-005453-4057qib7 16384 34 allogeneic allogeneic NN cord-005453-4057qib7 16384 35 and and CC cord-005453-4057qib7 16384 36 haploidentical haploidentical JJ cord-005453-4057qib7 16384 37 donor donor NN cord-005453-4057qib7 16384 38 mice mouse NNS cord-005453-4057qib7 16384 39 were be VBD cord-005453-4057qib7 16384 40 used use VBN cord-005453-4057qib7 16384 41 to to TO cord-005453-4057qib7 16384 42 determine determine VB cord-005453-4057qib7 16384 43 GvHD GvHD NNP cord-005453-4057qib7 16384 44 induced induce VBN cord-005453-4057qib7 16384 45 T t NN cord-005453-4057qib7 16384 46 cell cell NN cord-005453-4057qib7 16384 47 proliferation proliferation NN cord-005453-4057qib7 16384 48 in in IN cord-005453-4057qib7 16384 49 a a DT cord-005453-4057qib7 16384 50 mixed mixed JJ cord-005453-4057qib7 16384 51 lymphocyte lymphocyte NN cord-005453-4057qib7 16384 52 reaction reaction NN cord-005453-4057qib7 16384 53 ( ( -LRB- cord-005453-4057qib7 16384 54 MLR MLR NNP cord-005453-4057qib7 16384 55 ) ) -RRB- cord-005453-4057qib7 16384 56 . . . cord-005453-4057qib7 16385 1 Atm atm NN cord-005453-4057qib7 16385 2 - - HYPH cord-005453-4057qib7 16385 3 deficient deficient JJ cord-005453-4057qib7 16385 4 mice mouse NNS cord-005453-4057qib7 16385 5 were be VBD cord-005453-4057qib7 16385 6 treated treat VBN cord-005453-4057qib7 16385 7 with with IN cord-005453-4057qib7 16385 8 CP CP NNP cord-005453-4057qib7 16385 9 or or CC cord-005453-4057qib7 16385 10 reduced reduce VBN cord-005453-4057qib7 16385 11 CP cp NN cord-005453-4057qib7 16385 12 in in IN cord-005453-4057qib7 16385 13 combination combination NN cord-005453-4057qib7 16385 14 with with IN cord-005453-4057qib7 16385 15 Fludarabine Fludarabine NNP cord-005453-4057qib7 16385 16 ( ( -LRB- cord-005453-4057qib7 16385 17 FLU FLU NNP cord-005453-4057qib7 16385 18 ) ) -RRB- cord-005453-4057qib7 16385 19 and and CC cord-005453-4057qib7 16385 20 transplanted transplant VBN cord-005453-4057qib7 16385 21 with with IN cord-005453-4057qib7 16385 22 5x10 5x10 CD cord-005453-4057qib7 16385 23 6 6 CD cord-005453-4057qib7 16385 24 CD90.2 cd90.2 JJ cord-005453-4057qib7 16385 25 depleted deplete VBN cord-005453-4057qib7 16385 26 bone bone NN cord-005453-4057qib7 16385 27 marrow marrow NN cord-005453-4057qib7 16385 28 donor donor NN cord-005453-4057qib7 16385 29 cells cell NNS cord-005453-4057qib7 16385 30 from from IN cord-005453-4057qib7 16385 31 129 129 CD cord-005453-4057qib7 16385 32 / / SYM cord-005453-4057qib7 16385 33 SvEv SvEv NNP cord-005453-4057qib7 16385 34 GFP GFP NNP cord-005453-4057qib7 16385 35 - - HYPH cord-005453-4057qib7 16385 36 transfected transfecte VBN cord-005453-4057qib7 16385 37 wildtype wildtype NN cord-005453-4057qib7 16385 38 mice mouse NNS cord-005453-4057qib7 16385 39 ( ( -LRB- cord-005453-4057qib7 16385 40 syngeneic syngeneic NNS cord-005453-4057qib7 16385 41 ) ) -RRB- cord-005453-4057qib7 16385 42 or or CC cord-005453-4057qib7 16385 43 from from IN cord-005453-4057qib7 16385 44 mice mouse NNS cord-005453-4057qib7 16385 45 of of IN cord-005453-4057qib7 16385 46 the the DT cord-005453-4057qib7 16385 47 F1 F1 NNP cord-005453-4057qib7 16385 48 generation generation NN cord-005453-4057qib7 16385 49 of of IN cord-005453-4057qib7 16385 50 129 129 CD cord-005453-4057qib7 16385 51 / / SYM cord-005453-4057qib7 16385 52 SvEv SvEv NNP cord-005453-4057qib7 16385 53 wildtype wildtype JJ cord-005453-4057qib7 16385 54 mice mouse NNS cord-005453-4057qib7 16385 55 and and CC cord-005453-4057qib7 16385 56 C57BL/6 C57BL/6 NNP cord-005453-4057qib7 16385 57 mice mouse NNS cord-005453-4057qib7 16385 58 ( ( -LRB- cord-005453-4057qib7 16385 59 haploidentical haploidentical NNP cord-005453-4057qib7 16385 60 ) ) -RRB- cord-005453-4057qib7 16385 61 , , , cord-005453-4057qib7 16385 62 or or CC cord-005453-4057qib7 16385 63 from from IN cord-005453-4057qib7 16385 64 C57BL/6 C57BL/6 NNP cord-005453-4057qib7 16385 65 mice mouse NNS cord-005453-4057qib7 16385 66 ( ( -LRB- cord-005453-4057qib7 16385 67 allogeneic allogeneic NN cord-005453-4057qib7 16385 68 ) ) -RRB- cord-005453-4057qib7 16385 69 . . . cord-005453-4057qib7 16386 1 Tracking tracking NN cord-005453-4057qib7 16386 2 of of IN cord-005453-4057qib7 16386 3 GFP gfp NN cord-005453-4057qib7 16386 4 - - HYPH cord-005453-4057qib7 16386 5 positive positive JJ cord-005453-4057qib7 16386 6 donor donor NN cord-005453-4057qib7 16386 7 derived derive VBN cord-005453-4057qib7 16386 8 cells cell NNS cord-005453-4057qib7 16386 9 was be VBD cord-005453-4057qib7 16386 10 performed perform VBN cord-005453-4057qib7 16386 11 using use VBG cord-005453-4057qib7 16386 12 flow flow NN cord-005453-4057qib7 16386 13 cytometry cytometry NN cord-005453-4057qib7 16386 14 and and CC cord-005453-4057qib7 16386 15 Atm Atm NNP cord-005453-4057qib7 16386 16 PCR PCR NNP cord-005453-4057qib7 16386 17 . . . cord-005453-4057qib7 16387 1 Oxidative oxidative JJ cord-005453-4057qib7 16387 2 stress stress NN cord-005453-4057qib7 16387 3 and and CC cord-005453-4057qib7 16387 4 damage damage NN cord-005453-4057qib7 16387 5 were be VBD cord-005453-4057qib7 16387 6 detected detect VBN cord-005453-4057qib7 16387 7 by by IN cord-005453-4057qib7 16387 8 a a DT cord-005453-4057qib7 16387 9 RT RT NNP cord-005453-4057qib7 16387 10 Profiler profiler NN cord-005453-4057qib7 16387 11 PCR PCR NNP cord-005453-4057qib7 16387 12 Array Array NNP cord-005453-4057qib7 16387 13 and and CC cord-005453-4057qib7 16387 14 8-Hydroxy-2′deoxyguanosine 8-hydroxy-2′deoxyguanosine CD cord-005453-4057qib7 16387 15 . . . cord-005453-4057qib7 16388 1 Results result NNS cord-005453-4057qib7 16388 2 : : : cord-005453-4057qib7 16389 1 MLR MLR NNP cord-005453-4057qib7 16389 2 resulted result VBD cord-005453-4057qib7 16389 3 in in IN cord-005453-4057qib7 16389 4 an an DT cord-005453-4057qib7 16389 5 increased increase VBN cord-005453-4057qib7 16389 6 proliferation proliferation NN cord-005453-4057qib7 16389 7 of of IN cord-005453-4057qib7 16389 8 allogeneic allogeneic NN cord-005453-4057qib7 16389 9 donor donor NN cord-005453-4057qib7 16389 10 T t NN cord-005453-4057qib7 16389 11 cells cell NNS cord-005453-4057qib7 16389 12 compared compare VBN cord-005453-4057qib7 16389 13 to to IN cord-005453-4057qib7 16389 14 syngeneic syngeneic NNS cord-005453-4057qib7 16389 15 and and CC cord-005453-4057qib7 16389 16 haploidentical haploidentical JJ cord-005453-4057qib7 16389 17 donor donor NN cord-005453-4057qib7 16389 18 cells cell NNS cord-005453-4057qib7 16389 19 . . . cord-005453-4057qib7 16390 1 Response response NN cord-005453-4057qib7 16390 2 was be VBD cord-005453-4057qib7 16390 3 lower low JJR cord-005453-4057qib7 16390 4 on on IN cord-005453-4057qib7 16390 5 dendritic dendritic JJ cord-005453-4057qib7 16390 6 cells cell NNS cord-005453-4057qib7 16390 7 isolated isolate VBN cord-005453-4057qib7 16390 8 from from IN cord-005453-4057qib7 16390 9 Atm atm NN cord-005453-4057qib7 16390 10 - - HYPH cord-005453-4057qib7 16390 11 deficient deficient JJ cord-005453-4057qib7 16390 12 mice mouse NNS cord-005453-4057qib7 16390 13 compared compare VBN cord-005453-4057qib7 16390 14 to to IN cord-005453-4057qib7 16390 15 wildtype wildtype JJ cord-005453-4057qib7 16390 16 controls control NNS cord-005453-4057qib7 16390 17 . . . cord-005453-4057qib7 16391 1 In in IN cord-005453-4057qib7 16391 2 vivo vivo NN cord-005453-4057qib7 16391 3 results result NNS cord-005453-4057qib7 16391 4 showed show VBD cord-005453-4057qib7 16391 5 the the DT cord-005453-4057qib7 16391 6 restoration restoration NN cord-005453-4057qib7 16391 7 of of IN cord-005453-4057qib7 16391 8 T T NNP cord-005453-4057qib7 16391 9 cells cell NNS cord-005453-4057qib7 16391 10 in in IN cord-005453-4057qib7 16391 11 Atm atm NN cord-005453-4057qib7 16391 12 - - HYPH cord-005453-4057qib7 16391 13 deficient deficient JJ cord-005453-4057qib7 16391 14 mice mouse NNS cord-005453-4057qib7 16391 15 accompanied accompany VBN cord-005453-4057qib7 16391 16 by by IN cord-005453-4057qib7 16391 17 a a DT cord-005453-4057qib7 16391 18 prolonged prolonged JJ cord-005453-4057qib7 16391 19 life life NN cord-005453-4057qib7 16391 20 span span NN cord-005453-4057qib7 16391 21 and and CC cord-005453-4057qib7 16391 22 through through IN cord-005453-4057qib7 16391 23 reduction reduction NN cord-005453-4057qib7 16391 24 of of IN cord-005453-4057qib7 16391 25 thymic thymic JJ cord-005453-4057qib7 16391 26 tumors tumor NNS cord-005453-4057qib7 16391 27 . . . cord-005453-4057qib7 16392 1 However however RB cord-005453-4057qib7 16392 2 , , , cord-005453-4057qib7 16392 3 allogeneic allogeneic IN cord-005453-4057qib7 16392 4 stem stem NN cord-005453-4057qib7 16392 5 cell cell NN cord-005453-4057qib7 16392 6 transplantation transplantation NN cord-005453-4057qib7 16392 7 was be VBD cord-005453-4057qib7 16392 8 accompanied accompany VBN cord-005453-4057qib7 16392 9 with with IN cord-005453-4057qib7 16392 10 a a DT cord-005453-4057qib7 16392 11 higher high JJR cord-005453-4057qib7 16392 12 mortality mortality NN cord-005453-4057qib7 16392 13 rate rate NN cord-005453-4057qib7 16392 14 , , , cord-005453-4057qib7 16392 15 compared compare VBN cord-005453-4057qib7 16392 16 to to IN cord-005453-4057qib7 16392 17 the the DT cord-005453-4057qib7 16392 18 haploidentical haploidentical JJ cord-005453-4057qib7 16392 19 and and CC cord-005453-4057qib7 16392 20 syngeneic syngeneic NNS cord-005453-4057qib7 16392 21 setting setting NN cord-005453-4057qib7 16392 22 . . . cord-005453-4057qib7 16393 1 Decreased decrease VBN cord-005453-4057qib7 16394 1 antioxidative antioxidative JJ cord-005453-4057qib7 16394 2 capacity capacity NN cord-005453-4057qib7 16394 3 and and CC cord-005453-4057qib7 16394 4 a a DT cord-005453-4057qib7 16394 5 higher high JJR cord-005453-4057qib7 16394 6 DNA dna NN cord-005453-4057qib7 16394 7 - - HYPH cord-005453-4057qib7 16394 8 damage damage NN cord-005453-4057qib7 16394 9 were be VBD cord-005453-4057qib7 16394 10 seen see VBN cord-005453-4057qib7 16394 11 in in IN cord-005453-4057qib7 16394 12 CP CP NNP cord-005453-4057qib7 16394 13 treated treat VBN cord-005453-4057qib7 16394 14 Atmdeficient Atmdeficient NNP cord-005453-4057qib7 16394 15 mice mouse NNS cord-005453-4057qib7 16394 16 . . . cord-005453-4057qib7 16395 1 Conclusions conclusion NNS cord-005453-4057qib7 16395 2 : : : cord-005453-4057qib7 16396 1 Haploidentical Haploidentical NNP cord-005453-4057qib7 16396 2 HSCT HSCT NNP cord-005453-4057qib7 16396 3 seems seem VBZ cord-005453-4057qib7 16396 4 to to TO cord-005453-4057qib7 16396 5 be be VB cord-005453-4057qib7 16396 6 a a DT cord-005453-4057qib7 16396 7 feasible feasible JJ cord-005453-4057qib7 16396 8 strategy strategy NN cord-005453-4057qib7 16396 9 for for IN cord-005453-4057qib7 16396 10 A a NN cord-005453-4057qib7 16396 11 - - HYPH cord-005453-4057qib7 16396 12 T. t. NN cord-005453-4057qib7 16397 1 Our -PRON- PRP$ cord-005453-4057qib7 16397 2 data datum NNS cord-005453-4057qib7 16397 3 provided provide VBD cord-005453-4057qib7 16397 4 further further JJ cord-005453-4057qib7 16397 5 evidence evidence NN cord-005453-4057qib7 16397 6 for for IN cord-005453-4057qib7 16397 7 the the DT cord-005453-4057qib7 16397 8 high high JJ cord-005453-4057qib7 16397 9 sensitivity sensitivity NN cord-005453-4057qib7 16397 10 against against IN cord-005453-4057qib7 16397 11 ROS ROS NNP cord-005453-4057qib7 16397 12 - - HYPH cord-005453-4057qib7 16397 13 inducing induce VBG cord-005453-4057qib7 16397 14 agents agent NNS cord-005453-4057qib7 16397 15 in in IN cord-005453-4057qib7 16397 16 A A NNP cord-005453-4057qib7 16397 17 - - HYPH cord-005453-4057qib7 16397 18 T t NN cord-005453-4057qib7 16397 19 and and CC cord-005453-4057qib7 16397 20 this this DT cord-005453-4057qib7 16397 21 fact fact NN cord-005453-4057qib7 16397 22 needs need VBZ cord-005453-4057qib7 16397 23 to to TO cord-005453-4057qib7 16397 24 be be VB cord-005453-4057qib7 16397 25 taken take VBN cord-005453-4057qib7 16397 26 into into IN cord-005453-4057qib7 16397 27 consideration consideration NN cord-005453-4057qib7 16397 28 in in IN cord-005453-4057qib7 16397 29 the the DT cord-005453-4057qib7 16397 30 choice choice NN cord-005453-4057qib7 16397 31 of of IN cord-005453-4057qib7 16397 32 the the DT cord-005453-4057qib7 16397 33 host host NN cord-005453-4057qib7 16397 34 - - HYPH cord-005453-4057qib7 16397 35 conditioning conditioning NN cord-005453-4057qib7 16397 36 strategy strategy NN cord-005453-4057qib7 16397 37 . . . cord-005453-4057qib7 16398 1 Disclosure disclosure NN cord-005453-4057qib7 16398 2 : : : cord-005453-4057qib7 16398 3 Nothing nothing NN cord-005453-4057qib7 16398 4 to to TO cord-005453-4057qib7 16398 5 declare declare VB cord-005453-4057qib7 16398 6 This this DT cord-005453-4057qib7 16398 7 research research NN cord-005453-4057qib7 16398 8 received receive VBD cord-005453-4057qib7 16398 9 funding funding NN cord-005453-4057qib7 16398 10 from from IN cord-005453-4057qib7 16398 11 Action Action NNP cord-005453-4057qib7 16398 12 for for IN cord-005453-4057qib7 16398 13 A A NNP cord-005453-4057qib7 16398 14 - - HYPH cord-005453-4057qib7 16398 15 T T NNP cord-005453-4057qib7 16398 16 Charity Charity NNP cord-005453-4057qib7 16398 17 ( ( -LRB- cord-005453-4057qib7 16398 18 14GOU01 14gou01 CD cord-005453-4057qib7 16398 19 ) ) -RRB- cord-005453-4057qib7 16399 1 Background background NN cord-005453-4057qib7 16399 2 : : : cord-005453-4057qib7 16399 3 Prognosis prognosis NN cord-005453-4057qib7 16399 4 of of IN cord-005453-4057qib7 16399 5 pediatric pediatric JJ cord-005453-4057qib7 16399 6 patients patient NNS cord-005453-4057qib7 16399 7 and and CC cord-005453-4057qib7 16399 8 young young JJ cord-005453-4057qib7 16399 9 adults adult NNS cord-005453-4057qib7 16399 10 suffering suffer VBG cord-005453-4057qib7 16399 11 from from IN cord-005453-4057qib7 16399 12 refractory refractory JJ cord-005453-4057qib7 16399 13 or or CC cord-005453-4057qib7 16399 14 high high JJ cord-005453-4057qib7 16399 15 - - HYPH cord-005453-4057qib7 16399 16 risk risk NN cord-005453-4057qib7 16399 17 soft soft JJ cord-005453-4057qib7 16399 18 tissue tissue NN cord-005453-4057qib7 16399 19 sarcomas sarcoma NNS cord-005453-4057qib7 16399 20 remains remain VBZ cord-005453-4057qib7 16399 21 poor poor JJ cord-005453-4057qib7 16399 22 with with IN cord-005453-4057qib7 16399 23 limited limited JJ cord-005453-4057qib7 16399 24 improvement improvement NN cord-005453-4057qib7 16399 25 over over IN cord-005453-4057qib7 16399 26 the the DT cord-005453-4057qib7 16399 27 last last JJ cord-005453-4057qib7 16399 28 decades decade NNS cord-005453-4057qib7 16399 29 despite despite IN cord-005453-4057qib7 16399 30 multimodal multimodal JJ cord-005453-4057qib7 16399 31 treatment treatment NN cord-005453-4057qib7 16399 32 strategies strategy NNS cord-005453-4057qib7 16399 33 . . . cord-005453-4057qib7 16400 1 Replacing replace VBG cord-005453-4057qib7 16400 2 the the DT cord-005453-4057qib7 16400 3 immune immune JJ cord-005453-4057qib7 16400 4 system system NN cord-005453-4057qib7 16400 5 by by IN cord-005453-4057qib7 16400 6 an an DT cord-005453-4057qib7 16400 7 allogeneic allogeneic JJ cord-005453-4057qib7 16400 8 hematopoietic hematopoietic JJ cord-005453-4057qib7 16400 9 stem stem NN cord-005453-4057qib7 16400 10 cell cell NN cord-005453-4057qib7 16400 11 transplantation transplantation NN cord-005453-4057qib7 16400 12 ( ( -LRB- cord-005453-4057qib7 16400 13 HSCT HSCT NNP cord-005453-4057qib7 16400 14 ) ) -RRB- cord-005453-4057qib7 16400 15 in in IN cord-005453-4057qib7 16400 16 refractory refractory JJ cord-005453-4057qib7 16400 17 solid solid JJ cord-005453-4057qib7 16400 18 malignancies malignancy NNS cord-005453-4057qib7 16400 19 has have VBZ cord-005453-4057qib7 16400 20 been be VBN cord-005453-4057qib7 16400 21 proposed propose VBN cord-005453-4057qib7 16400 22 as as IN cord-005453-4057qib7 16400 23 a a DT cord-005453-4057qib7 16400 24 potentially potentially RB cord-005453-4057qib7 16400 25 curative curative JJ cord-005453-4057qib7 16400 26 therapy therapy NN cord-005453-4057qib7 16400 27 due due IN cord-005453-4057qib7 16400 28 to to IN cord-005453-4057qib7 16400 29 its -PRON- PRP$ cord-005453-4057qib7 16400 30 presumable presumable JJ cord-005453-4057qib7 16400 31 graft graft NN cord-005453-4057qib7 16400 32 versus versus IN cord-005453-4057qib7 16400 33 tumor tumor NN cord-005453-4057qib7 16400 34 effect effect NN cord-005453-4057qib7 16400 35 . . . cord-005453-4057qib7 16401 1 Based base VBN cord-005453-4057qib7 16401 2 on on IN cord-005453-4057qib7 16401 3 this this DT cord-005453-4057qib7 16401 4 concept concept NN cord-005453-4057qib7 16401 5 we -PRON- PRP cord-005453-4057qib7 16401 6 additionally additionally RB cord-005453-4057qib7 16401 7 performed perform VBD cord-005453-4057qib7 16401 8 consecutive consecutive JJ cord-005453-4057qib7 16401 9 donor donor NN cord-005453-4057qib7 16401 10 - - HYPH cord-005453-4057qib7 16401 11 derived derive VBN cord-005453-4057qib7 16401 12 lymphocyte lymphocyte NN cord-005453-4057qib7 16401 13 infusions infusion NNS cord-005453-4057qib7 16401 14 in in IN cord-005453-4057qib7 16401 15 allogeneic allogeneic JJ cord-005453-4057qib7 16401 16 HSCT hsct NN cord-005453-4057qib7 16401 17 - - HYPH cord-005453-4057qib7 16401 18 patients patient NNS cord-005453-4057qib7 16401 19 with with IN cord-005453-4057qib7 16401 20 refractory refractory JJ cord-005453-4057qib7 16401 21 or or CC cord-005453-4057qib7 16401 22 relapsed relapse VBN cord-005453-4057qib7 16401 23 solid solid JJ cord-005453-4057qib7 16401 24 malignancy malignancy NN cord-005453-4057qib7 16401 25 to to TO cord-005453-4057qib7 16401 26 further further RB cord-005453-4057qib7 16401 27 increase increase VB cord-005453-4057qib7 16401 28 anti anti JJ cord-005453-4057qib7 16401 29 - - JJ cord-005453-4057qib7 16401 30 tumor tumor JJ cord-005453-4057qib7 16401 31 efficacy efficacy NN cord-005453-4057qib7 16401 32 post post NN cord-005453-4057qib7 16401 33 - - NN cord-005453-4057qib7 16401 34 transplant transplant NN cord-005453-4057qib7 16401 35 . . . cord-005453-4057qib7 16402 1 Methods method NNS cord-005453-4057qib7 16402 2 : : : cord-005453-4057qib7 16402 3 Pediatric pediatric JJ cord-005453-4057qib7 16402 4 patients patient NNS cord-005453-4057qib7 16402 5 with with IN cord-005453-4057qib7 16402 6 relapsed relapse VBN cord-005453-4057qib7 16402 7 and/or and/or CC cord-005453-4057qib7 16402 8 refractory refractory JJ cord-005453-4057qib7 16402 9 cancers cancer NNS cord-005453-4057qib7 16402 10 or or CC cord-005453-4057qib7 16402 11 with with IN cord-005453-4057qib7 16402 12 delayed delay VBN cord-005453-4057qib7 16402 13 responses response NNS cord-005453-4057qib7 16402 14 to to IN cord-005453-4057qib7 16402 15 the the DT cord-005453-4057qib7 16402 16 respective respective JJ cord-005453-4057qib7 16402 17 induction induction NN cord-005453-4057qib7 16402 18 therapies therapy NNS cord-005453-4057qib7 16402 19 were be VBD cord-005453-4057qib7 16402 20 offered offer VBN cord-005453-4057qib7 16402 21 donorderived donorderived JJ cord-005453-4057qib7 16402 22 cellular cellular JJ cord-005453-4057qib7 16402 23 therapies therapy NNS cord-005453-4057qib7 16402 24 after after IN cord-005453-4057qib7 16402 25 immune immune JJ cord-005453-4057qib7 16402 26 system system NN cord-005453-4057qib7 16402 27 replacement replacement NN cord-005453-4057qib7 16402 28 by by IN cord-005453-4057qib7 16402 29 an an DT cord-005453-4057qib7 16402 30 allogeneic allogeneic JJ cord-005453-4057qib7 16402 31 HSCT HSCT NNP cord-005453-4057qib7 16402 32 . . . cord-005453-4057qib7 16403 1 Cellular cellular JJ cord-005453-4057qib7 16403 2 immunotherapies immunotherapy NNS cord-005453-4057qib7 16403 3 comprised comprise VBN cord-005453-4057qib7 16403 4 of of IN cord-005453-4057qib7 16403 5 donor donor NN cord-005453-4057qib7 16403 6 lymphocyte lymphocyte NN cord-005453-4057qib7 16403 7 infusions infusion NNS cord-005453-4057qib7 16403 8 ( ( -LRB- cord-005453-4057qib7 16403 9 DLI DLI NNP cord-005453-4057qib7 16403 10 ) ) -RRB- cord-005453-4057qib7 16403 11 , , , cord-005453-4057qib7 16403 12 natural natural JJ cord-005453-4057qib7 16403 13 killer killer NN cord-005453-4057qib7 16403 14 ( ( -LRB- cord-005453-4057qib7 16403 15 NK NK NNP cord-005453-4057qib7 16403 16 ) ) -RRB- cord-005453-4057qib7 16403 17 cell cell NN cord-005453-4057qib7 16403 18 or or CC cord-005453-4057qib7 16403 19 cytokine cytokine NN cord-005453-4057qib7 16403 20 - - HYPH cord-005453-4057qib7 16403 21 induced induce VBN cord-005453-4057qib7 16403 22 killer killer NN cord-005453-4057qib7 16403 23 ( ( -LRB- cord-005453-4057qib7 16403 24 CIK CIK NNP cord-005453-4057qib7 16403 25 ) ) -RRB- cord-005453-4057qib7 16403 26 cell cell NN cord-005453-4057qib7 16403 27 infusions infusion NNS cord-005453-4057qib7 16403 28 generated generate VBN cord-005453-4057qib7 16403 29 from from IN cord-005453-4057qib7 16403 30 the the DT cord-005453-4057qib7 16403 31 original original JJ cord-005453-4057qib7 16403 32 stem stem NN cord-005453-4057qib7 16403 33 cell cell NN cord-005453-4057qib7 16403 34 donors donor NNS cord-005453-4057qib7 16403 35 . . . cord-005453-4057qib7 16404 1 Allogeneic Allogeneic NNP cord-005453-4057qib7 16404 2 NK NK NNP cord-005453-4057qib7 16404 3 cells cell NNS cord-005453-4057qib7 16404 4 were be VBD cord-005453-4057qib7 16404 5 generated generate VBN cord-005453-4057qib7 16404 6 from from IN cord-005453-4057qib7 16404 7 unstimulated unstimulated JJ cord-005453-4057qib7 16404 8 leukapheresis leukapheresis NN cord-005453-4057qib7 16404 9 by by IN cord-005453-4057qib7 16404 10 a a DT cord-005453-4057qib7 16404 11 two two CD cord-005453-4057qib7 16404 12 - - HYPH cord-005453-4057qib7 16404 13 step step NN cord-005453-4057qib7 16404 14 purification purification NN cord-005453-4057qib7 16404 15 procedure procedure NN cord-005453-4057qib7 16404 16 using use VBG cord-005453-4057qib7 16404 17 immunomagnetic immunomagnetic JJ cord-005453-4057qib7 16404 18 CD3 CD3 NNP cord-005453-4057qib7 16404 19 T T NNP cord-005453-4057qib7 16404 20 cell cell NN cord-005453-4057qib7 16404 21 depletion depletion NN cord-005453-4057qib7 16404 22 , , , cord-005453-4057qib7 16404 23 followed follow VBN cord-005453-4057qib7 16404 24 by by IN cord-005453-4057qib7 16404 25 NK NK NNP cord-005453-4057qib7 16404 26 cell cell NN cord-005453-4057qib7 16404 27 enrichment enrichment NN cord-005453-4057qib7 16404 28 ( ( -LRB- cord-005453-4057qib7 16404 29 CD56 CD56 NNP cord-005453-4057qib7 16404 30 + + SYM cord-005453-4057qib7 16404 31 ) ) -RRB- cord-005453-4057qib7 16404 32 with with IN cord-005453-4057qib7 16404 33 or or CC cord-005453-4057qib7 16404 34 without without IN cord-005453-4057qib7 16404 35 in in IN cord-005453-4057qib7 16404 36 vitro vitro FW cord-005453-4057qib7 16404 37 IL-2 il-2 NN cord-005453-4057qib7 16404 38 stimulation stimulation NN cord-005453-4057qib7 16404 39 and and CC cord-005453-4057qib7 16404 40 expansion expansion NN cord-005453-4057qib7 16404 41 for for IN cord-005453-4057qib7 16404 42 9 9 CD cord-005453-4057qib7 16404 43 - - SYM cord-005453-4057qib7 16404 44 14 14 CD cord-005453-4057qib7 16404 45 days day NNS cord-005453-4057qib7 16404 46 . . . cord-005453-4057qib7 16405 1 For for IN cord-005453-4057qib7 16405 2 CIK CIK NNP cord-005453-4057qib7 16405 3 cell cell NN cord-005453-4057qib7 16405 4 generation generation NN cord-005453-4057qib7 16405 5 peripheral peripheral JJ cord-005453-4057qib7 16405 6 blood blood NN cord-005453-4057qib7 16405 7 mononuclear mononuclear NN cord-005453-4057qib7 16405 8 cells cell NNS cord-005453-4057qib7 16405 9 were be VBD cord-005453-4057qib7 16405 10 isolated isolate VBN cord-005453-4057qib7 16405 11 and and CC cord-005453-4057qib7 16405 12 activated activate VBN cord-005453-4057qib7 16405 13 by by IN cord-005453-4057qib7 16405 14 in in FW cord-005453-4057qib7 16405 15 vitro vitro FW cord-005453-4057qib7 16405 16 cytokine cytokine JJ cord-005453-4057qib7 16405 17 stimulation stimulation NN cord-005453-4057qib7 16405 18 ( ( -LRB- cord-005453-4057qib7 16405 19 INF INF NNP cord-005453-4057qib7 16405 20 - - HYPH cord-005453-4057qib7 16405 21 γ γ NNP cord-005453-4057qib7 16405 22 , , , cord-005453-4057qib7 16405 23 anti anti NNP cord-005453-4057qib7 16405 24 - - NNP cord-005453-4057qib7 16405 25 CD3 CD3 NNP cord-005453-4057qib7 16405 26 , , , cord-005453-4057qib7 16406 1 IL-2 IL-2 NNP cord-005453-4057qib7 16406 2 and and CC cord-005453-4057qib7 16406 3 IL-15 IL-15 NNP cord-005453-4057qib7 16406 4 ) ) -RRB- cord-005453-4057qib7 16406 5 an an DT cord-005453-4057qib7 16406 6 expanded expand VBN cord-005453-4057qib7 16406 7 over over IN cord-005453-4057qib7 16406 8 10 10 CD cord-005453-4057qib7 16406 9 - - SYM cord-005453-4057qib7 16406 10 12 12 CD cord-005453-4057qib7 16406 11 days day NNS cord-005453-4057qib7 16406 12 . . . cord-005453-4057qib7 16407 1 Expanded expand VBN cord-005453-4057qib7 16407 2 CIK CIK NNP cord-005453-4057qib7 16407 3 cells cell NNS cord-005453-4057qib7 16407 4 represented represent VBD cord-005453-4057qib7 16407 5 a a DT cord-005453-4057qib7 16407 6 heterogeneous heterogeneous JJ cord-005453-4057qib7 16407 7 population population NN cord-005453-4057qib7 16407 8 of of IN cord-005453-4057qib7 16407 9 polyclonal polyclonal JJ cord-005453-4057qib7 16407 10 T t NN cord-005453-4057qib7 16407 11 cells cell NNS cord-005453-4057qib7 16407 12 with with IN cord-005453-4057qib7 16407 13 in in IN cord-005453-4057qib7 16407 14 part part NN cord-005453-4057qib7 16407 15 shared share VBN cord-005453-4057qib7 16407 16 phenotypic phenotypic JJ cord-005453-4057qib7 16407 17 and and CC cord-005453-4057qib7 16407 18 functional functional JJ cord-005453-4057qib7 16407 19 properties property NNS cord-005453-4057qib7 16407 20 of of IN cord-005453-4057qib7 16407 21 NK NK NNP cord-005453-4057qib7 16407 22 cells cell NNS cord-005453-4057qib7 16407 23 . . . cord-005453-4057qib7 16408 1 Results result NNS cord-005453-4057qib7 16408 2 : : : cord-005453-4057qib7 16409 1 Between between IN cord-005453-4057qib7 16409 2 October October NNP cord-005453-4057qib7 16409 3 1 1 CD cord-005453-4057qib7 16409 4 st st NNP cord-005453-4057qib7 16409 5 2003 2003 CD cord-005453-4057qib7 16409 6 and and CC cord-005453-4057qib7 16409 7 January January NNP cord-005453-4057qib7 16409 8 1 1 CD cord-005453-4057qib7 16409 9 st st NNP cord-005453-4057qib7 16409 10 2014 2014 CD cord-005453-4057qib7 16409 11 a a DT cord-005453-4057qib7 16409 12 total total NN cord-005453-4057qib7 16409 13 of of IN cord-005453-4057qib7 16409 14 18 18 CD cord-005453-4057qib7 16409 15 patients patient NNS cord-005453-4057qib7 16409 16 ( ( -LRB- cord-005453-4057qib7 16409 17 eight eight CD cord-005453-4057qib7 16409 18 patients patient NNS cord-005453-4057qib7 16409 19 with with IN cord-005453-4057qib7 16409 20 rhabdomyosarcoma rhabdomyosarcoma NNP cord-005453-4057qib7 16409 21 , , , cord-005453-4057qib7 16409 22 one one CD cord-005453-4057qib7 16409 23 patient patient NN cord-005453-4057qib7 16409 24 with with IN cord-005453-4057qib7 16409 25 synovial synovial JJ cord-005453-4057qib7 16409 26 sarcoma sarcoma NN cord-005453-4057qib7 16409 27 , , , cord-005453-4057qib7 16409 28 two two CD cord-005453-4057qib7 16409 29 patients patient NNS cord-005453-4057qib7 16409 30 with with IN cord-005453-4057qib7 16409 31 Ewing Ewing NNP cord-005453-4057qib7 16409 32 sarcoma sarcoma NN cord-005453-4057qib7 16409 33 , , , cord-005453-4057qib7 16409 34 five five CD cord-005453-4057qib7 16409 35 patients patient NNS cord-005453-4057qib7 16409 36 with with IN cord-005453-4057qib7 16409 37 neuroblastoma neuroblastoma NN cord-005453-4057qib7 16409 38 , , , cord-005453-4057qib7 16409 39 one one CD cord-005453-4057qib7 16409 40 patient patient NN cord-005453-4057qib7 16409 41 with with IN cord-005453-4057qib7 16409 42 hepatoblastoma hepatoblastoma NNP cord-005453-4057qib7 16409 43 , , , cord-005453-4057qib7 16409 44 and and CC cord-005453-4057qib7 16409 45 one one CD cord-005453-4057qib7 16409 46 patient patient NN cord-005453-4057qib7 16409 47 with with IN cord-005453-4057qib7 16409 48 nasopharynx nasopharynx NN cord-005453-4057qib7 16409 49 carcinoma carcinoma NN cord-005453-4057qib7 16409 50 ) ) -RRB- cord-005453-4057qib7 16409 51 were be VBD cord-005453-4057qib7 16409 52 enrolled enrol VBN cord-005453-4057qib7 16409 53 . . . cord-005453-4057qib7 16410 1 Seven seven CD cord-005453-4057qib7 16410 2 of of IN cord-005453-4057qib7 16410 3 18 18 CD cord-005453-4057qib7 16410 4 ( ( -LRB- cord-005453-4057qib7 16410 5 39 39 CD cord-005453-4057qib7 16410 6 % % NN cord-005453-4057qib7 16410 7 ) ) -RRB- cord-005453-4057qib7 16410 8 patients patient NNS cord-005453-4057qib7 16410 9 in in IN cord-005453-4057qib7 16410 10 this this DT cord-005453-4057qib7 16410 11 study study NN cord-005453-4057qib7 16410 12 had have VBD cord-005453-4057qib7 16410 13 achieved achieve VBN cord-005453-4057qib7 16410 14 complete complete JJ cord-005453-4057qib7 16410 15 remission remission NN cord-005453-4057qib7 16410 16 ( ( -LRB- cord-005453-4057qib7 16410 17 CR CR NNP cord-005453-4057qib7 16410 18 ) ) -RRB- cord-005453-4057qib7 16410 19 before before IN cord-005453-4057qib7 16410 20 HSCT HSCT NNP cord-005453-4057qib7 16410 21 while while IN cord-005453-4057qib7 16410 22 another another DT cord-005453-4057qib7 16410 23 7 7 CD cord-005453-4057qib7 16410 24 of of IN cord-005453-4057qib7 16410 25 18 18 CD cord-005453-4057qib7 16410 26 ( ( -LRB- cord-005453-4057qib7 16410 27 39 39 CD cord-005453-4057qib7 16410 28 % % NN cord-005453-4057qib7 16410 29 ) ) -RRB- cord-005453-4057qib7 16410 30 patients patient NNS cord-005453-4057qib7 16410 31 had have VBD cord-005453-4057qib7 16410 32 obtained obtain VBN cord-005453-4057qib7 16410 33 at at IN cord-005453-4057qib7 16410 34 least least JJS cord-005453-4057qib7 16410 35 very very RB cord-005453-4057qib7 16410 36 good good JJ cord-005453-4057qib7 16410 37 partial partial JJ cord-005453-4057qib7 16410 38 or or CC cord-005453-4057qib7 16410 39 partial partial JJ cord-005453-4057qib7 16410 40 response response NN cord-005453-4057qib7 16410 41 ( ( -LRB- cord-005453-4057qib7 16410 42 VGPR VGPR NNP cord-005453-4057qib7 16410 43 or or CC cord-005453-4057qib7 16410 44 PR PR NNP cord-005453-4057qib7 16410 45 ) ) -RRB- cord-005453-4057qib7 16410 46 . . . cord-005453-4057qib7 16411 1 DLI DLI NNP cord-005453-4057qib7 16411 2 was be VBD cord-005453-4057qib7 16411 3 applied apply VBN cord-005453-4057qib7 16411 4 in in IN cord-005453-4057qib7 16411 5 5 5 CD cord-005453-4057qib7 16411 6 patients patient NNS cord-005453-4057qib7 16411 7 , , , cord-005453-4057qib7 16411 8 NK NK NNP cord-005453-4057qib7 16411 9 cell cell NN cord-005453-4057qib7 16411 10 treatment treatment NN cord-005453-4057qib7 16411 11 was be VBD cord-005453-4057qib7 16411 12 offered offer VBN cord-005453-4057qib7 16411 13 to to IN cord-005453-4057qib7 16411 14 another another DT cord-005453-4057qib7 16411 15 6 6 CD cord-005453-4057qib7 16411 16 patients patient NNS cord-005453-4057qib7 16411 17 , , , cord-005453-4057qib7 16411 18 while while IN cord-005453-4057qib7 16411 19 CIK CIK NNP cord-005453-4057qib7 16411 20 cell cell NN cord-005453-4057qib7 16411 21 therapy therapy NN cord-005453-4057qib7 16411 22 was be VBD cord-005453-4057qib7 16411 23 given give VBN cord-005453-4057qib7 16411 24 to to IN cord-005453-4057qib7 16411 25 7 7 CD cord-005453-4057qib7 16411 26 patients.1.5-year patients.1.5-year NNP cord-005453-4057qib7 16411 27 probabilities probability NNS cord-005453-4057qib7 16411 28 of of IN cord-005453-4057qib7 16411 29 overall overall JJ cord-005453-4057qib7 16411 30 survival survival NN cord-005453-4057qib7 16411 31 ( ( -LRB- cord-005453-4057qib7 16411 32 OS OS NNP cord-005453-4057qib7 16411 33 ) ) -RRB- cord-005453-4057qib7 16411 34 and and CC cord-005453-4057qib7 16411 35 progression progression NN cord-005453-4057qib7 16411 36 - - HYPH cord-005453-4057qib7 16411 37 free free JJ cord-005453-4057qib7 16411 38 survival survival NN cord-005453-4057qib7 16411 39 ( ( -LRB- cord-005453-4057qib7 16411 40 PFS PFS NNP cord-005453-4057qib7 16411 41 ) ) -RRB- cord-005453-4057qib7 16411 42 were be VBD cord-005453-4057qib7 16411 43 16.2 16.2 CD cord-005453-4057qib7 16411 44 % % NN cord-005453-4057qib7 16411 45 and and CC cord-005453-4057qib7 16411 46 15.9 15.9 CD cord-005453-4057qib7 16411 47 % % NN cord-005453-4057qib7 16411 48 for for IN cord-005453-4057qib7 16411 49 all all DT cord-005453-4057qib7 16411 50 patients patient NNS cord-005453-4057qib7 16411 51 with with IN cord-005453-4057qib7 16411 52 a a DT cord-005453-4057qib7 16411 53 median median NN cord-005453-4057qib7 16411 54 follow follow NN cord-005453-4057qib7 16411 55 up up IN cord-005453-4057qib7 16411 56 of of IN cord-005453-4057qib7 16411 57 8.5 8.5 CD cord-005453-4057qib7 16411 58 months month NNS cord-005453-4057qib7 16411 59 ( ( -LRB- cord-005453-4057qib7 16411 60 range range NN cord-005453-4057qib7 16411 61 , , , cord-005453-4057qib7 16411 62 1.5 1.5 CD cord-005453-4057qib7 16411 63 - - SYM cord-005453-4057qib7 16411 64 115.1 115.1 CD cord-005453-4057qib7 16411 65 months month NNS cord-005453-4057qib7 16411 66 ) ) -RRB- cord-005453-4057qib7 16411 67 . . . cord-005453-4057qib7 16412 1 Patients patient NNS cord-005453-4057qib7 16412 2 in in IN cord-005453-4057qib7 16412 3 CR CR NNP cord-005453-4057qib7 16412 4 at at IN cord-005453-4057qib7 16412 5 the the DT cord-005453-4057qib7 16412 6 time time NN cord-005453-4057qib7 16412 7 of of IN cord-005453-4057qib7 16412 8 immune immune JJ cord-005453-4057qib7 16412 9 cell cell NN cord-005453-4057qib7 16412 10 therapy therapy NN cord-005453-4057qib7 16412 11 ( ( -LRB- cord-005453-4057qib7 16412 12 IT it NN cord-005453-4057qib7 16412 13 ) ) -RRB- cord-005453-4057qib7 16412 14 showed show VBD cord-005453-4057qib7 16412 15 estimated estimate VBN cord-005453-4057qib7 16412 16 1.5-year 1.5-year CD cord-005453-4057qib7 16412 17 OS OS NNP cord-005453-4057qib7 16412 18 and and CC cord-005453-4057qib7 16412 19 PFS PFS NNP cord-005453-4057qib7 16412 20 of of IN cord-005453-4057qib7 16412 21 49.6 49.6 CD cord-005453-4057qib7 16412 22 % % NN cord-005453-4057qib7 16412 23 and and CC cord-005453-4057qib7 16412 24 42.7 42.7 CD cord-005453-4057qib7 16412 25 % % NN cord-005453-4057qib7 16412 26 , , , cord-005453-4057qib7 16412 27 respectively respectively RB cord-005453-4057qib7 16412 28 . . . cord-005453-4057qib7 16413 1 The the DT cord-005453-4057qib7 16413 2 majority majority NN cord-005453-4057qib7 16413 3 of of IN cord-005453-4057qib7 16413 4 patients patient NNS cord-005453-4057qib7 16413 5 relapsed relapse VBN cord-005453-4057qib7 16413 6 and and CC cord-005453-4057qib7 16413 7 ultimately ultimately RB cord-005453-4057qib7 16413 8 succumbed succumb VBD cord-005453-4057qib7 16413 9 to to IN cord-005453-4057qib7 16413 10 their -PRON- PRP$ cord-005453-4057qib7 16413 11 diseases disease NNS cord-005453-4057qib7 16413 12 with with IN cord-005453-4057qib7 16413 13 two two CD cord-005453-4057qib7 16413 14 of of IN cord-005453-4057qib7 16413 15 18 18 CD cord-005453-4057qib7 16413 16 ( ( -LRB- cord-005453-4057qib7 16413 17 11 11 CD cord-005453-4057qib7 16413 18 % % NN cord-005453-4057qib7 16413 19 ) ) -RRB- cord-005453-4057qib7 16413 20 patients patient NNS cord-005453-4057qib7 16413 21 still still RB cord-005453-4057qib7 16413 22 being be VBG cord-005453-4057qib7 16413 23 alive alive JJ cord-005453-4057qib7 16413 24 9.6 9.6 CD cord-005453-4057qib7 16413 25 and and CC cord-005453-4057qib7 16413 26 9.3 9.3 CD cord-005453-4057qib7 16413 27 years year NNS cord-005453-4057qib7 16413 28 after after IN cord-005453-4057qib7 16413 29 IT it PRP cord-005453-4057qib7 16413 30 . . . cord-005453-4057qib7 16414 1 Cumulative cumulative JJ cord-005453-4057qib7 16414 2 incidence incidence NN cord-005453-4057qib7 16414 3 of of IN cord-005453-4057qib7 16414 4 relapse relapse NN cord-005453-4057qib7 16414 5 was be VBD cord-005453-4057qib7 16414 6 79.8 79.8 CD cord-005453-4057qib7 16414 7 % % NN cord-005453-4057qib7 16414 8 at at IN cord-005453-4057qib7 16414 9 1.5 1.5 CD cord-005453-4057qib7 16414 10 years year NNS cord-005453-4057qib7 16414 11 . . . cord-005453-4057qib7 16415 1 T T NNP cord-005453-4057qib7 16415 2 cell cell NN cord-005453-4057qib7 16415 3 engraftment engraftment NN cord-005453-4057qib7 16415 4 and and CC cord-005453-4057qib7 16415 5 immune immune JJ cord-005453-4057qib7 16415 6 reconstitution reconstitution NN cord-005453-4057qib7 16415 7 ( ( -LRB- cord-005453-4057qib7 16415 8 IR IR NNP cord-005453-4057qib7 16415 9 ) ) -RRB- cord-005453-4057qib7 16415 10 was be VBD cord-005453-4057qib7 16415 11 improved improve VBN cord-005453-4057qib7 16415 12 by by IN cord-005453-4057qib7 16415 13 IT IT NNP cord-005453-4057qib7 16415 14 , , , cord-005453-4057qib7 16415 15 and and CC cord-005453-4057qib7 16415 16 correlated correlate VBN cord-005453-4057qib7 16415 17 with with IN cord-005453-4057qib7 16415 18 treatment treatment NN cord-005453-4057qib7 16415 19 response response NN cord-005453-4057qib7 16415 20 . . . cord-005453-4057qib7 16416 1 However however RB cord-005453-4057qib7 16416 2 , , , cord-005453-4057qib7 16416 3 two two CD cord-005453-4057qib7 16416 4 of of IN cord-005453-4057qib7 16416 5 18 18 CD cord-005453-4057qib7 16416 6 heavily heavily RB cord-005453-4057qib7 16416 7 pretreated pretreate VBN cord-005453-4057qib7 16416 8 patients patient NNS cord-005453-4057qib7 16416 9 ( ( -LRB- cord-005453-4057qib7 16416 10 11 11 CD cord-005453-4057qib7 16416 11 % % NN cord-005453-4057qib7 16416 12 ) ) -RRB- cord-005453-4057qib7 16416 13 died die VBD cord-005453-4057qib7 16416 14 due due IN cord-005453-4057qib7 16416 15 to to IN cord-005453-4057qib7 16416 16 cumulative cumulative JJ cord-005453-4057qib7 16416 17 treatment treatment NN cord-005453-4057qib7 16416 18 - - HYPH cord-005453-4057qib7 16416 19 related relate VBN cord-005453-4057qib7 16416 20 mortality mortality NN cord-005453-4057qib7 16416 21 ( ( -LRB- cord-005453-4057qib7 16416 22 TRM TRM NNP cord-005453-4057qib7 16416 23 ) ) -RRB- cord-005453-4057qib7 16416 24 . . . cord-005453-4057qib7 16417 1 Furthermore furthermore RB cord-005453-4057qib7 16417 2 , , , cord-005453-4057qib7 16417 3 acute acute JJ cord-005453-4057qib7 16417 4 graft graft NN cord-005453-4057qib7 16417 5 - - HYPH cord-005453-4057qib7 16417 6 versus versus IN cord-005453-4057qib7 16417 7 - - HYPH cord-005453-4057qib7 16417 8 host host NN cord-005453-4057qib7 16417 9 - - HYPH cord-005453-4057qib7 16417 10 disease disease NN cord-005453-4057qib7 16417 11 ( ( -LRB- cord-005453-4057qib7 16417 12 aGVHD aGVHD NNP cord-005453-4057qib7 16417 13 ) ) -RRB- cord-005453-4057qib7 16417 14 occurred occur VBD cord-005453-4057qib7 16417 15 in in IN cord-005453-4057qib7 16417 16 9 9 CD cord-005453-4057qib7 16417 17 of of IN cord-005453-4057qib7 16417 18 18 18 CD cord-005453-4057qib7 16417 19 patients patient NNS cord-005453-4057qib7 16417 20 ( ( -LRB- cord-005453-4057qib7 16417 21 50 50 CD cord-005453-4057qib7 16417 22 % % NN cord-005453-4057qib7 16417 23 ) ) -RRB- cord-005453-4057qib7 16417 24 with with IN cord-005453-4057qib7 16417 25 aGVHD aGVHD NNP cord-005453-4057qib7 16417 26 grade grade NN cord-005453-4057qib7 16417 27 I I NNP cord-005453-4057qib7 16417 28 - - HYPH cord-005453-4057qib7 16417 29 II II NNP cord-005453-4057qib7 16417 30 observed observe VBD cord-005453-4057qib7 16417 31 in in IN cord-005453-4057qib7 16417 32 6 6 CD cord-005453-4057qib7 16417 33 ( ( -LRB- cord-005453-4057qib7 16417 34 33 33 CD cord-005453-4057qib7 16417 35 % % NN cord-005453-4057qib7 16417 36 ) ) -RRB- cord-005453-4057qib7 16417 37 and and CC cord-005453-4057qib7 16417 38 aGVHD aGVHD NNP cord-005453-4057qib7 16417 39 grade grade NN cord-005453-4057qib7 16417 40 III III NNP cord-005453-4057qib7 16417 41 seen see VBN cord-005453-4057qib7 16417 42 in in IN cord-005453-4057qib7 16417 43 three three CD cord-005453-4057qib7 16417 44 ( ( -LRB- cord-005453-4057qib7 16417 45 17 17 CD cord-005453-4057qib7 16417 46 % % NN cord-005453-4057qib7 16417 47 ) ) -RRB- cord-005453-4057qib7 16417 48 patients patient NNS cord-005453-4057qib7 16417 49 . . . cord-005453-4057qib7 16418 1 Conclusions conclusion NNS cord-005453-4057qib7 16418 2 : : : cord-005453-4057qib7 16419 1 Altogether altogether RB cord-005453-4057qib7 16419 2 , , , cord-005453-4057qib7 16419 3 the the DT cord-005453-4057qib7 16419 4 results result NNS cord-005453-4057qib7 16419 5 of of IN cord-005453-4057qib7 16419 6 this this DT cord-005453-4057qib7 16419 7 study study NN cord-005453-4057qib7 16419 8 indicate indicate VBP cord-005453-4057qib7 16419 9 that that IN cord-005453-4057qib7 16419 10 allogeneic allogeneic NN cord-005453-4057qib7 16419 11 donor donor NN cord-005453-4057qib7 16419 12 - - HYPH cord-005453-4057qib7 16419 13 derived derive VBN cord-005453-4057qib7 16419 14 cellular cellular JJ cord-005453-4057qib7 16419 15 therapy therapy NN cord-005453-4057qib7 16419 16 at at IN cord-005453-4057qib7 16419 17 its -PRON- PRP$ cord-005453-4057qib7 16419 18 current current JJ cord-005453-4057qib7 16419 19 state state NN cord-005453-4057qib7 16419 20 offers offer VBZ cord-005453-4057qib7 16419 21 curative curative JJ cord-005453-4057qib7 16419 22 benefit benefit NN cord-005453-4057qib7 16419 23 in in IN cord-005453-4057qib7 16419 24 selected select VBN cord-005453-4057qib7 16419 25 refractory refractory JJ cord-005453-4057qib7 16419 26 childhood childhood NN cord-005453-4057qib7 16419 27 cancers cancer NNS cord-005453-4057qib7 16419 28 but but CC cord-005453-4057qib7 16419 29 warrants warrant NNS cord-005453-4057qib7 16419 30 further further JJ cord-005453-4057qib7 16419 31 improvement improvement NN cord-005453-4057qib7 16419 32 . . . cord-005453-4057qib7 16420 1 Background background NN cord-005453-4057qib7 16420 2 : : : cord-005453-4057qib7 16421 1 Allogeneic allogeneic IN cord-005453-4057qib7 16421 2 stem stem VBP cord-005453-4057qib7 16421 3 cell cell NN cord-005453-4057qib7 16421 4 transplantation transplantation NN cord-005453-4057qib7 16421 5 ( ( -LRB- cord-005453-4057qib7 16421 6 allo allo FW cord-005453-4057qib7 16421 7 - - HYPH cord-005453-4057qib7 16421 8 SCT SCT NNP cord-005453-4057qib7 16421 9 ) ) -RRB- cord-005453-4057qib7 16421 10 is be VBZ cord-005453-4057qib7 16421 11 the the DT cord-005453-4057qib7 16421 12 only only JJ cord-005453-4057qib7 16421 13 curative curative JJ cord-005453-4057qib7 16421 14 treatment treatment NN cord-005453-4057qib7 16421 15 option option NN cord-005453-4057qib7 16421 16 for for IN cord-005453-4057qib7 16421 17 a a DT cord-005453-4057qib7 16421 18 variety variety NN cord-005453-4057qib7 16421 19 of of IN cord-005453-4057qib7 16421 20 nonmalignant nonmalignant JJ cord-005453-4057qib7 16421 21 diseases disease NNS cord-005453-4057qib7 16421 22 . . . cord-005453-4057qib7 16422 1 The the DT cord-005453-4057qib7 16422 2 success success NN cord-005453-4057qib7 16422 3 of of IN cord-005453-4057qib7 16422 4 allo allo NN cord-005453-4057qib7 16422 5 - - HYPH cord-005453-4057qib7 16422 6 SCT SCT NNP cord-005453-4057qib7 16422 7 is be VBZ cord-005453-4057qib7 16422 8 strongly strongly RB cord-005453-4057qib7 16422 9 associated associate VBN cord-005453-4057qib7 16422 10 with with IN cord-005453-4057qib7 16422 11 rapid rapid JJ cord-005453-4057qib7 16422 12 and and CC cord-005453-4057qib7 16422 13 sustained sustained JJ cord-005453-4057qib7 16422 14 immune immune JJ cord-005453-4057qib7 16422 15 reconstitution reconstitution NN cord-005453-4057qib7 16422 16 ( ( -LRB- cord-005453-4057qib7 16422 17 IR IR NNP cord-005453-4057qib7 16422 18 ) ) -RRB- cord-005453-4057qib7 16422 19 . . . cord-005453-4057qib7 16423 1 We -PRON- PRP cord-005453-4057qib7 16423 2 analyzed analyze VBD cord-005453-4057qib7 16423 3 the the DT cord-005453-4057qib7 16423 4 IR IR NNP cord-005453-4057qib7 16423 5 in in IN cord-005453-4057qib7 16423 6 patients patient NNS cord-005453-4057qib7 16423 7 who who WP cord-005453-4057qib7 16423 8 received receive VBD cord-005453-4057qib7 16423 9 an an DT cord-005453-4057qib7 16423 10 allo allo NN cord-005453-4057qib7 16423 11 - - HYPH cord-005453-4057qib7 16423 12 SCT SCT NNP cord-005453-4057qib7 16423 13 for for IN cord-005453-4057qib7 16423 14 nonmalignant nonmalignant NNP cord-005453-4057qib7 16423 15 diseases disease NNS cord-005453-4057qib7 16423 16 . . . cord-005453-4057qib7 16424 1 IR IR NNP cord-005453-4057qib7 16424 2 was be VBD cord-005453-4057qib7 16424 3 assessed assess VBN cord-005453-4057qib7 16424 4 on on IN cord-005453-4057qib7 16424 5 days day NNS cord-005453-4057qib7 16424 6 +30 +30 CD cord-005453-4057qib7 16424 7 , , , cord-005453-4057qib7 16424 8 +60 +60 NNP cord-005453-4057qib7 16424 9 , , , cord-005453-4057qib7 16424 10 +90 +90 CD cord-005453-4057qib7 16424 11 , , , cord-005453-4057qib7 16424 12 +180 +180 NNP cord-005453-4057qib7 16424 13 and and CC cord-005453-4057qib7 16424 14 +365 +365 NNP cord-005453-4057qib7 16424 15 after after IN cord-005453-4057qib7 16424 16 allo allo NN cord-005453-4057qib7 16424 17 - - HYPH cord-005453-4057qib7 16424 18 SCT sct NN cord-005453-4057qib7 16424 19 analyzing analyzing NN cord-005453-4057qib7 16424 20 leukocytes leukocyte NNS cord-005453-4057qib7 16424 21 , , , cord-005453-4057qib7 16424 22 lymphocytes lymphocyte NNS cord-005453-4057qib7 16424 23 , , , cord-005453-4057qib7 16424 24 monocytes monocyte NNS cord-005453-4057qib7 16424 25 , , , cord-005453-4057qib7 16424 26 CD3 CD3 NNP cord-005453-4057qib7 16424 27 + + CC cord-005453-4057qib7 16424 28 T T NNP cord-005453-4057qib7 16424 29 cells cell NNS cord-005453-4057qib7 16424 30 , , , cord-005453-4057qib7 16424 31 CD3 CD3 NNP cord-005453-4057qib7 16424 32 + + CC cord-005453-4057qib7 16424 33 CD4 CD4 NNP cord-005453-4057qib7 16424 34 + + CC cord-005453-4057qib7 16424 35 T T NNP cord-005453-4057qib7 16424 36 helper helper NN cord-005453-4057qib7 16424 37 cells cell NNS cord-005453-4057qib7 16424 38 , , , cord-005453-4057qib7 16424 39 CD3 CD3 NNP cord-005453-4057qib7 16424 40 + + CC cord-005453-4057qib7 16424 41 CD8 CD8 NNP cord-005453-4057qib7 16424 42 + + CC cord-005453-4057qib7 16424 43 cytotoxic cytotoxic JJ cord-005453-4057qib7 16424 44 T t NN cord-005453-4057qib7 16424 45 cells cell NNS cord-005453-4057qib7 16424 46 , , , cord-005453-4057qib7 16424 47 CD3 CD3 NNP cord-005453-4057qib7 16424 48 -CD56 -cd56 DT cord-005453-4057qib7 16424 49 + + JJ cord-005453-4057qib7 16424 50 natural natural JJ cord-005453-4057qib7 16424 51 killer killer NN cord-005453-4057qib7 16424 52 ( ( -LRB- cord-005453-4057qib7 16424 53 NK NK NNP cord-005453-4057qib7 16424 54 ) ) -RRB- cord-005453-4057qib7 16424 55 cells cell NNS cord-005453-4057qib7 16424 56 and and CC cord-005453-4057qib7 16424 57 CD19 CD19 NNP cord-005453-4057qib7 16424 58 + + CC cord-005453-4057qib7 16424 59 B b NN cord-005453-4057qib7 16424 60 cells cell NNS cord-005453-4057qib7 16424 61 . . . cord-005453-4057qib7 16425 1 Methods method NNS cord-005453-4057qib7 16425 2 : : : cord-005453-4057qib7 16425 3 We -PRON- PRP cord-005453-4057qib7 16425 4 analyzed analyze VBD cord-005453-4057qib7 16425 5 IR IR NNP cord-005453-4057qib7 16425 6 - - HYPH cord-005453-4057qib7 16425 7 data datum NNS cord-005453-4057qib7 16425 8 of of IN cord-005453-4057qib7 16425 9 116 116 CD cord-005453-4057qib7 16425 10 consecutive consecutive JJ cord-005453-4057qib7 16425 11 patients patient NNS cord-005453-4057qib7 16425 12 receiving receive VBG cord-005453-4057qib7 16425 13 allo allo NN cord-005453-4057qib7 16425 14 - - HYPH cord-005453-4057qib7 16425 15 SCTs sct NNS cord-005453-4057qib7 16425 16 between between IN cord-005453-4057qib7 16425 17 September September NNP cord-005453-4057qib7 16425 18 2001 2001 CD cord-005453-4057qib7 16425 19 and and CC cord-005453-4057qib7 16425 20 November November NNP cord-005453-4057qib7 16425 21 2018 2018 CD cord-005453-4057qib7 16425 22 . . . cord-005453-4057qib7 16426 1 Indications indication NNS cord-005453-4057qib7 16426 2 of of IN cord-005453-4057qib7 16426 3 allo allo NNP cord-005453-4057qib7 16426 4 - - HYPH cord-005453-4057qib7 16426 5 SCT SCT NNP cord-005453-4057qib7 16426 6 were be VBD cord-005453-4057qib7 16426 7 hereditary hereditary JJ cord-005453-4057qib7 16426 8 anemias anemia NNS cord-005453-4057qib7 16426 9 ( ( -LRB- cord-005453-4057qib7 16426 10 thalassemia thalassemia NN cord-005453-4057qib7 16426 11 , , , cord-005453-4057qib7 16426 12 sickle sickle NN cord-005453-4057qib7 16426 13 cell cell NN cord-005453-4057qib7 16426 14 disease disease NN cord-005453-4057qib7 16426 15 , , , cord-005453-4057qib7 16426 16 Diamond Diamond NNP cord-005453-4057qib7 16426 17 Blackfan Blackfan NNP cord-005453-4057qib7 16426 18 Anemia anemia NN cord-005453-4057qib7 16426 19 ; ; : cord-005453-4057qib7 16426 20 HA HA NNP cord-005453-4057qib7 16426 21 , , , cord-005453-4057qib7 16426 22 n=35 n=35 NN cord-005453-4057qib7 16426 23 , , , cord-005453-4057qib7 16426 24 30 30 CD cord-005453-4057qib7 16426 25 % % NN cord-005453-4057qib7 16426 26 ) ) -RRB- cord-005453-4057qib7 16426 27 , , , cord-005453-4057qib7 16426 28 inherited inherit VBN cord-005453-4057qib7 16426 29 bone bone NN cord-005453-4057qib7 16426 30 marrow marrow NN cord-005453-4057qib7 16426 31 failure failure NN cord-005453-4057qib7 16426 32 syndrome syndrome NN cord-005453-4057qib7 16426 33 ( ( -LRB- cord-005453-4057qib7 16426 34 Fanconi Fanconi NNP cord-005453-4057qib7 16426 35 anemia anemia NN cord-005453-4057qib7 16426 36 , , , cord-005453-4057qib7 16426 37 severe severe JJ cord-005453-4057qib7 16426 38 aplastic aplastic JJ cord-005453-4057qib7 16426 39 anemia anemia NN cord-005453-4057qib7 16426 40 , , , cord-005453-4057qib7 16426 41 others other NNS cord-005453-4057qib7 16426 42 ; ; : cord-005453-4057qib7 16426 43 BMFS BMFS NNP cord-005453-4057qib7 16426 44 , , , cord-005453-4057qib7 16426 45 n=34 n=34 NNP cord-005453-4057qib7 16426 46 , , , cord-005453-4057qib7 16426 47 29 29 CD cord-005453-4057qib7 16426 48 % % NN cord-005453-4057qib7 16426 49 ) ) -RRB- cord-005453-4057qib7 16426 50 , , , cord-005453-4057qib7 16426 51 hemophagocytic hemophagocytic JJ cord-005453-4057qib7 16426 52 lymphohistiocytosis lymphohistiocytosis NN cord-005453-4057qib7 16426 53 ( ( -LRB- cord-005453-4057qib7 16426 54 HLH HLH NNP cord-005453-4057qib7 16426 55 , , , cord-005453-4057qib7 16426 56 n=12 n=12 NNP cord-005453-4057qib7 16426 57 , , , cord-005453-4057qib7 16426 58 10 10 CD cord-005453-4057qib7 16426 59 % % NN cord-005453-4057qib7 16426 60 ) ) -RRB- cord-005453-4057qib7 16426 61 , , , cord-005453-4057qib7 16426 62 immunodeficiency immunodeficiency NN cord-005453-4057qib7 16426 63 ( ( -LRB- cord-005453-4057qib7 16426 64 ID ID NNP cord-005453-4057qib7 16426 65 , , , cord-005453-4057qib7 16426 66 n=28 n=28 NN cord-005453-4057qib7 16426 67 , , , cord-005453-4057qib7 16426 68 24 24 CD cord-005453-4057qib7 16426 69 % % NN cord-005453-4057qib7 16426 70 ) ) -RRB- cord-005453-4057qib7 16426 71 and and CC cord-005453-4057qib7 16426 72 metabolic metabolic JJ cord-005453-4057qib7 16426 73 disorders disorder NNS cord-005453-4057qib7 16426 74 ( ( -LRB- cord-005453-4057qib7 16426 75 n=7 n=7 NNS cord-005453-4057qib7 16426 76 , , , cord-005453-4057qib7 16426 77 6 6 CD cord-005453-4057qib7 16426 78 % % NN cord-005453-4057qib7 16426 79 ) ) -RRB- cord-005453-4057qib7 16426 80 . . . cord-005453-4057qib7 16427 1 The the DT cord-005453-4057qib7 16427 2 median median JJ cord-005453-4057qib7 16427 3 age age NN cord-005453-4057qib7 16427 4 at at IN cord-005453-4057qib7 16427 5 allo allo NN cord-005453-4057qib7 16427 6 - - HYPH cord-005453-4057qib7 16427 7 SCT SCT NNP cord-005453-4057qib7 16427 8 was be VBD cord-005453-4057qib7 16427 9 7 7 CD cord-005453-4057qib7 16427 10 years year NNS cord-005453-4057qib7 16427 11 ( ( -LRB- cord-005453-4057qib7 16427 12 range range NN cord-005453-4057qib7 16427 13 , , , cord-005453-4057qib7 16427 14 0.2 0.2 CD cord-005453-4057qib7 16427 15 -26 -26 CD cord-005453-4057qib7 16427 16 ) ) -RRB- cord-005453-4057qib7 16427 17 and and CC cord-005453-4057qib7 16428 1 at at IN cord-005453-4057qib7 16428 2 diagnosis diagnosis NN cord-005453-4057qib7 16428 3 0.8 0.8 CD cord-005453-4057qib7 16428 4 years year NNS cord-005453-4057qib7 16428 5 ( ( -LRB- cord-005453-4057qib7 16428 6 range range NN cord-005453-4057qib7 16428 7 , , , cord-005453-4057qib7 16428 8 -0.5 -0.5 XX cord-005453-4057qib7 16429 1 -17.8).Patients -17.8).Patients NNP cord-005453-4057qib7 16429 2 received receive VBD cord-005453-4057qib7 16429 3 1 1 CD cord-005453-4057qib7 16429 4 st st NNP cord-005453-4057qib7 16429 5 allo allo NNP cord-005453-4057qib7 16429 6 - - HYPH cord-005453-4057qib7 16429 7 SCT SCT NNP cord-005453-4057qib7 16429 8 from from IN cord-005453-4057qib7 16429 9 MSD MSD NNP cord-005453-4057qib7 16429 10 / / SYM cord-005453-4057qib7 16429 11 MFD MFD NNP cord-005453-4057qib7 16429 12 ( ( -LRB- cord-005453-4057qib7 16430 1 n=53 n=53 NNP cord-005453-4057qib7 16430 2 , , , cord-005453-4057qib7 16430 3 46 46 CD cord-005453-4057qib7 16430 4 % % NN cord-005453-4057qib7 16430 5 ) ) -RRB- cord-005453-4057qib7 16430 6 , , , cord-005453-4057qib7 16430 7 MUD MUD NNP cord-005453-4057qib7 16430 8 ( ( -LRB- cord-005453-4057qib7 16430 9 n=42 n=42 NN cord-005453-4057qib7 16430 10 , , , cord-005453-4057qib7 16430 11 36 36 CD cord-005453-4057qib7 16430 12 % % NN cord-005453-4057qib7 16430 13 ) ) -RRB- cord-005453-4057qib7 16430 14 , , , cord-005453-4057qib7 16430 15 haploidentical haploidentical JJ cord-005453-4057qib7 16430 16 mismatch mismatch NN cord-005453-4057qib7 16430 17 family family NN cord-005453-4057qib7 16430 18 donors donor NNS cord-005453-4057qib7 16430 19 ( ( -LRB- cord-005453-4057qib7 16430 20 n=15 n=15 NNP cord-005453-4057qib7 16430 21 , , , cord-005453-4057qib7 16430 22 13 13 CD cord-005453-4057qib7 16430 23 % % NN cord-005453-4057qib7 16430 24 ) ) -RRB- cord-005453-4057qib7 16430 25 and and CC cord-005453-4057qib7 16430 26 MMUD MMUD NNP cord-005453-4057qib7 16430 27 ( ( -LRB- cord-005453-4057qib7 16430 28 n=6 n=6 JJ cord-005453-4057qib7 16430 29 , , , cord-005453-4057qib7 16430 30 5 5 CD cord-005453-4057qib7 16430 31 % % NN cord-005453-4057qib7 16430 32 ) ) -RRB- cord-005453-4057qib7 16430 33 . . . cord-005453-4057qib7 16431 1 Conditioning conditioning NN cord-005453-4057qib7 16431 2 regimens regimen NNS cord-005453-4057qib7 16431 3 were be VBD cord-005453-4057qib7 16431 4 Busulphan Busulphan NNP cord-005453-4057qib7 16431 5 - - HYPH cord-005453-4057qib7 16431 6 based base VBN cord-005453-4057qib7 16431 7 ( ( -LRB- cord-005453-4057qib7 16431 8 n=14 n=14 NN cord-005453-4057qib7 16431 9 , , , cord-005453-4057qib7 16431 10 12 12 CD cord-005453-4057qib7 16431 11 % % NN cord-005453-4057qib7 16431 12 ) ) -RRB- cord-005453-4057qib7 16431 13 , , , cord-005453-4057qib7 16431 14 Treosulphan Treosulphan NNP cord-005453-4057qib7 16431 15 - - HYPH cord-005453-4057qib7 16431 16 based base VBN cord-005453-4057qib7 16431 17 ( ( -LRB- cord-005453-4057qib7 16431 18 n=45 n=45 NNS cord-005453-4057qib7 16431 19 , , , cord-005453-4057qib7 16431 20 39 39 CD cord-005453-4057qib7 16431 21 % % NN cord-005453-4057qib7 16431 22 ) ) -RRB- cord-005453-4057qib7 16431 23 , , , cord-005453-4057qib7 16431 24 Flu Flu NNP cord-005453-4057qib7 16431 25 - - HYPH cord-005453-4057qib7 16431 26 Mel Mel NNP cord-005453-4057qib7 16431 27 - - HYPH cord-005453-4057qib7 16431 28 Thio Thio NNP cord-005453-4057qib7 16431 29 ( ( -LRB- cord-005453-4057qib7 16431 30 n=35 n=35 NNP cord-005453-4057qib7 16431 31 , , , cord-005453-4057qib7 16431 32 30 30 CD cord-005453-4057qib7 16431 33 % % NN cord-005453-4057qib7 16431 34 ) ) -RRB- cord-005453-4057qib7 16431 35 or or CC cord-005453-4057qib7 16431 36 others other NNS cord-005453-4057qib7 16431 37 ( ( -LRB- cord-005453-4057qib7 16431 38 n=22 n=22 NNP cord-005453-4057qib7 16431 39 , , , cord-005453-4057qib7 16431 40 19 19 CD cord-005453-4057qib7 16431 41 % % NN cord-005453-4057qib7 16431 42 ) ) -RRB- cord-005453-4057qib7 16431 43 . . . cord-005453-4057qib7 16432 1 Graft graft NN cord-005453-4057qib7 16432 2 sources source NNS cord-005453-4057qib7 16432 3 were be VBD cord-005453-4057qib7 16432 4 BM BM NNP cord-005453-4057qib7 16432 5 ( ( -LRB- cord-005453-4057qib7 16432 6 n=84 n=84 '' cord-005453-4057qib7 16432 7 , , , cord-005453-4057qib7 16432 8 72 72 CD cord-005453-4057qib7 16432 9 % % NN cord-005453-4057qib7 16432 10 ) ) -RRB- cord-005453-4057qib7 16432 11 and and CC cord-005453-4057qib7 16432 12 PBSC PBSC NNP cord-005453-4057qib7 16432 13 ( ( -LRB- cord-005453-4057qib7 16432 14 n=32 n=32 NNP cord-005453-4057qib7 16432 15 , , , cord-005453-4057qib7 16432 16 28%).In 28%).in CD cord-005453-4057qib7 16432 17 order order NN cord-005453-4057qib7 16432 18 to to TO cord-005453-4057qib7 16432 19 consider consider VB cord-005453-4057qib7 16432 20 the the DT cord-005453-4057qib7 16432 21 age age NN cord-005453-4057qib7 16432 22 - - HYPH cord-005453-4057qib7 16432 23 dependency dependency NN cord-005453-4057qib7 16432 24 of of IN cord-005453-4057qib7 16432 25 IR IR NNP cord-005453-4057qib7 16432 26 we -PRON- PRP cord-005453-4057qib7 16432 27 normalized normalize VBD cord-005453-4057qib7 16432 28 each each DT cord-005453-4057qib7 16432 29 absolute absolute JJ cord-005453-4057qib7 16432 30 cell cell NN cord-005453-4057qib7 16432 31 count count NN cord-005453-4057qib7 16432 32 with with IN cord-005453-4057qib7 16432 33 its -PRON- PRP$ cord-005453-4057qib7 16432 34 corresponding correspond VBG cord-005453-4057qib7 16432 35 age age NN cord-005453-4057qib7 16432 36 - - HYPH cord-005453-4057qib7 16432 37 specific specific JJ cord-005453-4057qib7 16432 38 expected expect VBN cord-005453-4057qib7 16432 39 mean mean JJ cord-005453-4057qib7 16432 40 values value NNS cord-005453-4057qib7 16432 41 . . . cord-005453-4057qib7 16433 1 ( ( -LRB- cord-005453-4057qib7 16433 2 Huenecke Huenecke NNP cord-005453-4057qib7 16433 3 et et FW cord-005453-4057qib7 16433 4 al al NNP cord-005453-4057qib7 16433 5 . . . cord-005453-4057qib7 16434 1 ; ; : cord-005453-4057qib7 16434 2 Eur Eur NNP cord-005453-4057qib7 16434 3 J J NNP cord-005453-4057qib7 16434 4 Haematol Haematol NNP cord-005453-4057qib7 16434 5 ; ; : cord-005453-4057qib7 16434 6 2008 2008 CD cord-005453-4057qib7 16434 7 ) ) -RRB- cord-005453-4057qib7 16435 1 Results result NNS cord-005453-4057qib7 16435 2 : : : cord-005453-4057qib7 16436 1 The the DT cord-005453-4057qib7 16436 2 IR IR NNP cord-005453-4057qib7 16436 3 pattern pattern NN cord-005453-4057qib7 16436 4 was be VBD cord-005453-4057qib7 16436 5 similar similar JJ cord-005453-4057qib7 16436 6 between between IN cord-005453-4057qib7 16436 7 the the DT cord-005453-4057qib7 16436 8 HA HA NNP cord-005453-4057qib7 16436 9 and and CC cord-005453-4057qib7 16436 10 BMFS BMFS NNP cord-005453-4057qib7 16436 11 groups group NNS cord-005453-4057qib7 16436 12 . . . cord-005453-4057qib7 16437 1 The the DT cord-005453-4057qib7 16437 2 CD4 CD4 NNP cord-005453-4057qib7 16437 3 + + CC cord-005453-4057qib7 16437 4 T t NN cord-005453-4057qib7 16437 5 cells cell NNS cord-005453-4057qib7 16437 6 were be VBD cord-005453-4057qib7 16437 7 recovering recover VBG cord-005453-4057qib7 16437 8 slightly slightly RB cord-005453-4057qib7 16437 9 faster fast RBR cord-005453-4057qib7 16437 10 in in IN cord-005453-4057qib7 16437 11 HA HA NNP cord-005453-4057qib7 16437 12 patients patient NNS cord-005453-4057qib7 16437 13 compared compare VBN cord-005453-4057qib7 16437 14 to to IN cord-005453-4057qib7 16437 15 the the DT cord-005453-4057qib7 16437 16 recovery recovery NN cord-005453-4057qib7 16437 17 of of IN cord-005453-4057qib7 16437 18 BMFS BMFS NNP cord-005453-4057qib7 16437 19 patients patient NNS cord-005453-4057qib7 16437 20 . . . cord-005453-4057qib7 16438 1 Monocytes Monocytes NNP cord-005453-4057qib7 16438 2 and and CC cord-005453-4057qib7 16438 3 NK NK NNP cord-005453-4057qib7 16438 4 cells cell NNS cord-005453-4057qib7 16438 5 proliferate proliferate VBP cord-005453-4057qib7 16438 6 very very RB cord-005453-4057qib7 16438 7 fast fast RB cord-005453-4057qib7 16438 8 . . . cord-005453-4057qib7 16439 1 At at IN cord-005453-4057qib7 16439 2 day day NN cord-005453-4057qib7 16439 3 +60 +60 CD cord-005453-4057qib7 16439 4 half half NN cord-005453-4057qib7 16439 5 of of IN cord-005453-4057qib7 16439 6 the the DT cord-005453-4057qib7 16439 7 patients patient NNS cord-005453-4057qib7 16439 8 already already RB cord-005453-4057qib7 16439 9 reached reach VBD cord-005453-4057qib7 16439 10 their -PRON- PRP$ cord-005453-4057qib7 16439 11 respective respective JJ cord-005453-4057qib7 16439 12 monocytes monocyte NNS cord-005453-4057qib7 16439 13 reference reference NN cord-005453-4057qib7 16439 14 value value NN cord-005453-4057qib7 16439 15 except except IN cord-005453-4057qib7 16439 16 for for IN cord-005453-4057qib7 16439 17 ID ID NNP cord-005453-4057qib7 16439 18 patients patient NNS cord-005453-4057qib7 16439 19 , , , cord-005453-4057qib7 16439 20 who who WP cord-005453-4057qib7 16439 21 reached reach VBD cord-005453-4057qib7 16439 22 80 80 CD cord-005453-4057qib7 16439 23 % % NN cord-005453-4057qib7 16439 24 of of IN cord-005453-4057qib7 16439 25 the the DT cord-005453-4057qib7 16439 26 reference reference NN cord-005453-4057qib7 16439 27 value value NN cord-005453-4057qib7 16439 28 at at IN cord-005453-4057qib7 16439 29 the the DT cord-005453-4057qib7 16439 30 end end NN cord-005453-4057qib7 16439 31 of of IN cord-005453-4057qib7 16439 32 the the DT cord-005453-4057qib7 16439 33 first first JJ cord-005453-4057qib7 16439 34 year year NN cord-005453-4057qib7 16439 35 . . . cord-005453-4057qib7 16440 1 CD3 CD3 NNP cord-005453-4057qib7 16440 2 + + CC cord-005453-4057qib7 16440 3 CD8 CD8 NNP cord-005453-4057qib7 16440 4 + + CC cord-005453-4057qib7 16440 5 cytotoxic cytotoxic JJ cord-005453-4057qib7 16440 6 T t NN cord-005453-4057qib7 16440 7 cells cell NNS cord-005453-4057qib7 16440 8 recovered recover VBN cord-005453-4057qib7 16440 9 significantly significantly RB cord-005453-4057qib7 16440 10 faster fast RBR cord-005453-4057qib7 16440 11 in in IN cord-005453-4057qib7 16440 12 patients patient NNS cord-005453-4057qib7 16440 13 with with IN cord-005453-4057qib7 16440 14 hematologic hematologic JJ cord-005453-4057qib7 16440 15 diseases disease NNS cord-005453-4057qib7 16440 16 compared compare VBN cord-005453-4057qib7 16440 17 to to IN cord-005453-4057qib7 16440 18 patients patient NNS cord-005453-4057qib7 16440 19 with with IN cord-005453-4057qib7 16440 20 HLH HLH NNP cord-005453-4057qib7 16440 21 ( ( -LRB- cord-005453-4057qib7 16440 22 P p NN cord-005453-4057qib7 16440 23 < < XX cord-005453-4057qib7 16440 24 0.001 0.001 CD cord-005453-4057qib7 16440 25 ) ) -RRB- cord-005453-4057qib7 16440 26 and and CC cord-005453-4057qib7 16440 27 ID ID NNP cord-005453-4057qib7 16440 28 ( ( -LRB- cord-005453-4057qib7 16440 29 P=0.047 P=0.047 NNS cord-005453-4057qib7 16440 30 ) ) -RRB- cord-005453-4057qib7 16440 31 . . . cord-005453-4057qib7 16441 1 Half half NN cord-005453-4057qib7 16441 2 of of IN cord-005453-4057qib7 16441 3 the the DT cord-005453-4057qib7 16441 4 patients patient NNS cord-005453-4057qib7 16441 5 reached reach VBD cord-005453-4057qib7 16441 6 the the DT cord-005453-4057qib7 16441 7 reference reference NN cord-005453-4057qib7 16441 8 value value NN cord-005453-4057qib7 16441 9 of of IN cord-005453-4057qib7 16441 10 cytotoxic cytotoxic JJ cord-005453-4057qib7 16441 11 T t NN cord-005453-4057qib7 16441 12 cells cell NNS cord-005453-4057qib7 16441 13 in in IN cord-005453-4057qib7 16441 14 the the DT cord-005453-4057qib7 16441 15 hematologic hematologic JJ cord-005453-4057qib7 16441 16 diseases disease NNS cord-005453-4057qib7 16441 17 group group NN cord-005453-4057qib7 16441 18 at at IN cord-005453-4057qib7 16441 19 day day NN cord-005453-4057qib7 16441 20 +365 +365 NNP cord-005453-4057qib7 16441 21 . . . cord-005453-4057qib7 16442 1 By by IN cord-005453-4057qib7 16442 2 far far RB cord-005453-4057qib7 16442 3 inferior inferior JJ cord-005453-4057qib7 16442 4 was be VBD cord-005453-4057qib7 16442 5 the the DT cord-005453-4057qib7 16442 6 IR IR NNP cord-005453-4057qib7 16442 7 for for IN cord-005453-4057qib7 16442 8 the the DT cord-005453-4057qib7 16442 9 HLH HLH NNP cord-005453-4057qib7 16442 10 patients patient NNS cord-005453-4057qib7 16442 11 . . . cord-005453-4057qib7 16443 1 In in IN cord-005453-4057qib7 16443 2 this this DT cord-005453-4057qib7 16443 3 group group NN cord-005453-4057qib7 16443 4 only only RB cord-005453-4057qib7 16443 5 50 50 CD cord-005453-4057qib7 16443 6 % % NN cord-005453-4057qib7 16443 7 of of IN cord-005453-4057qib7 16443 8 the the DT cord-005453-4057qib7 16443 9 patients patient NNS cord-005453-4057qib7 16443 10 reached reach VBD cord-005453-4057qib7 16443 11 the the DT cord-005453-4057qib7 16443 12 45 45 CD cord-005453-4057qib7 16443 13 th th XX cord-005453-4057qib7 16443 14 percentile percentile NN cord-005453-4057qib7 16443 15 of of IN cord-005453-4057qib7 16443 16 the the DT cord-005453-4057qib7 16443 17 healthy healthy JJ cord-005453-4057qib7 16443 18 age age NN cord-005453-4057qib7 16443 19 - - HYPH cord-005453-4057qib7 16443 20 matched match VBN cord-005453-4057qib7 16443 21 reference reference NN cord-005453-4057qib7 16443 22 . . . cord-005453-4057qib7 16444 1 In in IN cord-005453-4057qib7 16444 2 the the DT cord-005453-4057qib7 16444 3 ID ID NNP cord-005453-4057qib7 16444 4 group group NN cord-005453-4057qib7 16444 5 50 50 CD cord-005453-4057qib7 16444 6 % % NN cord-005453-4057qib7 16444 7 of of IN cord-005453-4057qib7 16444 8 all all DT cord-005453-4057qib7 16444 9 patients patient NNS cord-005453-4057qib7 16444 10 reached reach VBD cord-005453-4057qib7 16444 11 the the DT cord-005453-4057qib7 16444 12 87 87 CD cord-005453-4057qib7 16444 13 th th XX cord-005453-4057qib7 16444 14 percentile percentile NN cord-005453-4057qib7 16444 15 of of IN cord-005453-4057qib7 16444 16 the the DT cord-005453-4057qib7 16444 17 age age NN cord-005453-4057qib7 16444 18 - - HYPH cord-005453-4057qib7 16444 19 matched match VBN cord-005453-4057qib7 16444 20 reference reference NN cord-005453-4057qib7 16444 21 group group NN cord-005453-4057qib7 16444 22 at at IN cord-005453-4057qib7 16444 23 day day NN cord-005453-4057qib7 16445 1 +365.B +365.b NN cord-005453-4057qib7 16445 2 cells cell NNS cord-005453-4057qib7 16445 3 are be VBP cord-005453-4057qib7 16445 4 profoundly profoundly RB cord-005453-4057qib7 16445 5 decreased decrease VBN cord-005453-4057qib7 16445 6 at at IN cord-005453-4057qib7 16445 7 day day NN cord-005453-4057qib7 16445 8 +30 +30 CD cord-005453-4057qib7 16445 9 in in IN cord-005453-4057qib7 16445 10 all all DT cord-005453-4057qib7 16445 11 groups group NNS cord-005453-4057qib7 16445 12 . . . cord-005453-4057qib7 16446 1 However however RB cord-005453-4057qib7 16446 2 , , , cord-005453-4057qib7 16446 3 the the DT cord-005453-4057qib7 16446 4 longitudinal longitudinal JJ cord-005453-4057qib7 16446 5 expansion expansion NN cord-005453-4057qib7 16446 6 of of IN cord-005453-4057qib7 16446 7 B b NN cord-005453-4057qib7 16446 8 cells cell NNS cord-005453-4057qib7 16446 9 was be VBD cord-005453-4057qib7 16446 10 significantly significantly RB cord-005453-4057qib7 16446 11 lower low JJR cord-005453-4057qib7 16446 12 both both CC cord-005453-4057qib7 16446 13 in in IN cord-005453-4057qib7 16446 14 the the DT cord-005453-4057qib7 16446 15 ID ID NNP cord-005453-4057qib7 16446 16 group group NN cord-005453-4057qib7 16446 17 and and CC cord-005453-4057qib7 16446 18 HLH HLH NNP cord-005453-4057qib7 16446 19 group group NN cord-005453-4057qib7 16446 20 compared compare VBN cord-005453-4057qib7 16446 21 to to IN cord-005453-4057qib7 16446 22 the the DT cord-005453-4057qib7 16446 23 hematologic hematologic JJ cord-005453-4057qib7 16446 24 diseases disease NNS cord-005453-4057qib7 16446 25 group group NN cord-005453-4057qib7 16446 26 . . . cord-005453-4057qib7 16447 1 At at IN cord-005453-4057qib7 16447 2 day day NN cord-005453-4057qib7 16447 3 +365 +365 NNP cord-005453-4057qib7 16447 4 fifty fifty CD cord-005453-4057qib7 16447 5 percent percent NN cord-005453-4057qib7 16447 6 of of IN cord-005453-4057qib7 16447 7 patients patient NNS cord-005453-4057qib7 16447 8 with with IN cord-005453-4057qib7 16447 9 ID ID NNP cord-005453-4057qib7 16447 10 , , , cord-005453-4057qib7 16447 11 HLH HLH NNP cord-005453-4057qib7 16447 12 and and CC cord-005453-4057qib7 16447 13 hematologic hematologic JJ cord-005453-4057qib7 16447 14 diseases disease NNS cord-005453-4057qib7 16447 15 reached reach VBD cord-005453-4057qib7 16447 16 the the DT cord-005453-4057qib7 16447 17 37 37 CD cord-005453-4057qib7 16447 18 th th XX cord-005453-4057qib7 16447 19 percentile percentile NN cord-005453-4057qib7 16447 20 , , , cord-005453-4057qib7 16447 21 52 52 CD cord-005453-4057qib7 16447 22 th th XX cord-005453-4057qib7 16447 23 percentile percentile NN cord-005453-4057qib7 16447 24 and and CC cord-005453-4057qib7 16447 25 the the DT cord-005453-4057qib7 16447 26 100 100 CD cord-005453-4057qib7 16447 27 th th XX cord-005453-4057qib7 16447 28 percentile percentile NN cord-005453-4057qib7 16447 29 , , , cord-005453-4057qib7 16447 30 respectively respectively RB cord-005453-4057qib7 16447 31 ( ( -LRB- cord-005453-4057qib7 16447 32 P p NN cord-005453-4057qib7 16447 33 < < XX cord-005453-4057qib7 16447 34 0.001 0.001 CD cord-005453-4057qib7 16447 35 ; ; : cord-005453-4057qib7 16447 36 P=0.027).Conclusions P=0.027).Conclusions NNP cord-005453-4057qib7 16447 37 : : : cord-005453-4057qib7 16448 1 Allo Allo NNP cord-005453-4057qib7 16448 2 - - HYPH cord-005453-4057qib7 16448 3 SCT SCT NNP cord-005453-4057qib7 16448 4 is be VBZ cord-005453-4057qib7 16448 5 the the DT cord-005453-4057qib7 16448 6 only only JJ cord-005453-4057qib7 16448 7 curative curative JJ cord-005453-4057qib7 16448 8 option option NN cord-005453-4057qib7 16448 9 for for IN cord-005453-4057qib7 16448 10 patients patient NNS cord-005453-4057qib7 16448 11 with with IN cord-005453-4057qib7 16448 12 nonmalignant nonmalignant NNP cord-005453-4057qib7 16448 13 diseases disease NNS cord-005453-4057qib7 16448 14 . . . cord-005453-4057qib7 16449 1 IR IR NNP cord-005453-4057qib7 16449 2 is be VBZ cord-005453-4057qib7 16449 3 dynamic dynamic JJ cord-005453-4057qib7 16449 4 and and CC cord-005453-4057qib7 16449 5 revealed reveal VBD cord-005453-4057qib7 16449 6 a a DT cord-005453-4057qib7 16449 7 complex complex JJ cord-005453-4057qib7 16449 8 diversity diversity NN cord-005453-4057qib7 16449 9 pattern pattern NN cord-005453-4057qib7 16449 10 with with IN cord-005453-4057qib7 16449 11 regard regard NN cord-005453-4057qib7 16449 12 to to IN cord-005453-4057qib7 16449 13 the the DT cord-005453-4057qib7 16449 14 original original JJ cord-005453-4057qib7 16449 15 disease disease NN cord-005453-4057qib7 16449 16 . . . cord-005453-4057qib7 16450 1 To to TO cord-005453-4057qib7 16450 2 investigate investigate VB cord-005453-4057qib7 16450 3 factors factor NNS cord-005453-4057qib7 16450 4 influencing influence VBG cord-005453-4057qib7 16450 5 IR IR NNP cord-005453-4057qib7 16450 6 after after IN cord-005453-4057qib7 16450 7 allo allo NN cord-005453-4057qib7 16450 8 - - HYPH cord-005453-4057qib7 16450 9 SCT SCT NNP cord-005453-4057qib7 16450 10 is be VBZ cord-005453-4057qib7 16450 11 crucial crucial JJ cord-005453-4057qib7 16450 12 to to TO cord-005453-4057qib7 16450 13 improve improve VB cord-005453-4057qib7 16450 14 outcome outcome NN cord-005453-4057qib7 16450 15 of of IN cord-005453-4057qib7 16450 16 these these DT cord-005453-4057qib7 16450 17 patients patient NNS cord-005453-4057qib7 16450 18 . . . cord-005453-4057qib7 16451 1 Disclosure disclosure NN cord-005453-4057qib7 16451 2 : : : cord-005453-4057qib7 16451 3 Nothing nothing NN cord-005453-4057qib7 16451 4 to to TO cord-005453-4057qib7 16451 5 declare declare VB cord-005453-4057qib7 16451 6 . . . cord-005453-4057qib7 16452 1 Allogeneic allogeneic IN cord-005453-4057qib7 16452 2 hematopoietic hematopoietic JJ cord-005453-4057qib7 16452 3 stem stem NN cord-005453-4057qib7 16452 4 cell cell NN cord-005453-4057qib7 16452 5 transplantation transplantation NN cord-005453-4057qib7 16452 6 in in IN cord-005453-4057qib7 16452 7 patients patient NNS cord-005453-4057qib7 16452 8 with with IN cord-005453-4057qib7 16452 9 myelodysplastic myelodysplastic JJ cord-005453-4057qib7 16452 10 syndrome syndrome NN cord-005453-4057qib7 16452 11 of of IN cord-005453-4057qib7 16452 12 relatively relatively RB cord-005453-4057qib7 16452 13 high high JJ cord-005453-4057qib7 16452 14 - - HYPH cord-005453-4057qib7 16452 15 risk risk NN cord-005453-4057qib7 16452 16 groups group NNS cord-005453-4057qib7 16452 17 : : : cord-005453-4057qib7 16452 18 curative curative JJ cord-005453-4057qib7 16452 19 effect effect NN cord-005453-4057qib7 16452 20 analysis analysis NN cord-005453-4057qib7 16452 21 and and CC cord-005453-4057qib7 16452 22 optimal optimal JJ cord-005453-4057qib7 16452 23 timing timing NN cord-005453-4057qib7 16452 24 selection selection NN cord-005453-4057qib7 16452 25 Results result NNS cord-005453-4057qib7 16452 26 : : : cord-005453-4057qib7 16452 27 Among among IN cord-005453-4057qib7 16452 28 the the DT cord-005453-4057qib7 16452 29 135 135 CD cord-005453-4057qib7 16452 30 patients patient NNS cord-005453-4057qib7 16452 31 , , , cord-005453-4057qib7 16452 32 133 133 CD cord-005453-4057qib7 16452 33 patients patient NNS cord-005453-4057qib7 16452 34 were be VBD cord-005453-4057qib7 16452 35 transplanted transplant VBN cord-005453-4057qib7 16452 36 successfully successfully RB cord-005453-4057qib7 16452 37 . . . cord-005453-4057qib7 16453 1 The the DT cord-005453-4057qib7 16453 2 3-year 3-year CD cord-005453-4057qib7 16453 3 overall overall JJ cord-005453-4057qib7 16453 4 survival survival NN cord-005453-4057qib7 16453 5 ( ( -LRB- cord-005453-4057qib7 16453 6 OS os NN cord-005453-4057qib7 16453 7 ) ) -RRB- cord-005453-4057qib7 16453 8 rate rate NN cord-005453-4057qib7 16453 9 and and CC cord-005453-4057qib7 16453 10 disease disease NN cord-005453-4057qib7 16453 11 - - HYPH cord-005453-4057qib7 16453 12 free free JJ cord-005453-4057qib7 16453 13 survival survival NN cord-005453-4057qib7 16453 14 ( ( -LRB- cord-005453-4057qib7 16453 15 DFS DFS NNP cord-005453-4057qib7 16453 16 ) ) -RRB- cord-005453-4057qib7 16453 17 rate rate NN cord-005453-4057qib7 16453 18 was be VBD cord-005453-4057qib7 16453 19 76.8 76.8 CD cord-005453-4057qib7 16453 20 % % NN cord-005453-4057qib7 16453 21 ±4.2 ±4.2 JJ cord-005453-4057qib7 16453 22 % % NN cord-005453-4057qib7 16453 23 and and CC cord-005453-4057qib7 16453 24 76.7%±4.3 76.7%±4.3 CD cord-005453-4057qib7 16453 25 % % NN cord-005453-4057qib7 16453 26 respectively respectively RB cord-005453-4057qib7 16453 27 . . . cord-005453-4057qib7 16454 1 The the DT cord-005453-4057qib7 16454 2 3-year 3-year CD cord-005453-4057qib7 16454 3 cumulative cumulative JJ cord-005453-4057qib7 16454 4 relapse relapse NN cord-005453-4057qib7 16454 5 rate rate NN cord-005453-4057qib7 16454 6 ( ( -LRB- cord-005453-4057qib7 16454 7 RR RR NNP cord-005453-4057qib7 16454 8 ) ) -RRB- cord-005453-4057qib7 16454 9 and and CC cord-005453-4057qib7 16454 10 the the DT cord-005453-4057qib7 16454 11 non non JJ cord-005453-4057qib7 16454 12 - - JJ cord-005453-4057qib7 16454 13 relapse relapse JJ cord-005453-4057qib7 16454 14 mortality mortality NN cord-005453-4057qib7 16454 15 ( ( -LRB- cord-005453-4057qib7 16454 16 NRM NRM NNP cord-005453-4057qib7 16454 17 ) ) -RRB- cord-005453-4057qib7 16454 18 rate rate NN cord-005453-4057qib7 16454 19 was be VBD cord-005453-4057qib7 16454 20 13.9%±0.1 13.9%±0.1 CD cord-005453-4057qib7 16454 21 % % NN cord-005453-4057qib7 16454 22 and and CC cord-005453-4057qib7 16454 23 18.4%±0.1 18.4%±0.1 CD cord-005453-4057qib7 16454 24 % % NN cord-005453-4057qib7 16454 25 respectively respectively RB cord-005453-4057qib7 16454 26 . . . cord-005453-4057qib7 16455 1 The the DT cord-005453-4057qib7 16455 2 incidence incidence NN cord-005453-4057qib7 16455 3 of of IN cord-005453-4057qib7 16455 4 grade grade NN cord-005453-4057qib7 16455 5 II II NNP cord-005453-4057qib7 16455 6 - - HYPH cord-005453-4057qib7 16455 7 IV IV NNP cord-005453-4057qib7 16455 8 acute acute JJ cord-005453-4057qib7 16455 9 graft graft NN cord-005453-4057qib7 16455 10 versus versus IN cord-005453-4057qib7 16455 11 host host NN cord-005453-4057qib7 16455 12 disease disease NN cord-005453-4057qib7 16455 13 ( ( -LRB- cord-005453-4057qib7 16455 14 aGVHD aGVHD NNP cord-005453-4057qib7 16455 15 ) ) -RRB- cord-005453-4057qib7 16455 16 was be VBD cord-005453-4057qib7 16455 17 25.2%±0.1 25.2%±0.1 CD cord-005453-4057qib7 16455 18 % % NN cord-005453-4057qib7 16455 19 . . . cord-005453-4057qib7 16456 1 For for IN cord-005453-4057qib7 16456 2 the the DT cord-005453-4057qib7 16456 3 patients patient NNS cord-005453-4057qib7 16456 4 who who WP cord-005453-4057qib7 16456 5 survived survive VBD cord-005453-4057qib7 16456 6 more more JJR cord-005453-4057qib7 16456 7 than than IN cord-005453-4057qib7 16456 8 100 100 CD cord-005453-4057qib7 16456 9 days day NNS cord-005453-4057qib7 16456 10 after after IN cord-005453-4057qib7 16456 11 allo allo NN cord-005453-4057qib7 16456 12 - - HYPH cord-005453-4057qib7 16456 13 HCT HCT NNP cord-005453-4057qib7 16456 14 , , , cord-005453-4057qib7 16456 15 the the DT cord-005453-4057qib7 16456 16 2 2 CD cord-005453-4057qib7 16456 17 years year NNS cord-005453-4057qib7 16456 18 cumulative cumulative JJ cord-005453-4057qib7 16456 19 incidence incidence NN cord-005453-4057qib7 16456 20 of of IN cord-005453-4057qib7 16456 21 chronic chronic JJ cord-005453-4057qib7 16456 22 graft graft NN cord-005453-4057qib7 16456 23 versus versus IN cord-005453-4057qib7 16456 24 host host NN cord-005453-4057qib7 16456 25 disease disease NN cord-005453-4057qib7 16456 26 ( ( -LRB- cord-005453-4057qib7 16456 27 cGVHD cGVHD NNP cord-005453-4057qib7 16456 28 ) ) -RRB- cord-005453-4057qib7 16456 29 was be VBD cord-005453-4057qib7 16456 30 33.4%±0.2 33.4%±0.2 NNP cord-005453-4057qib7 16456 31 % % NN cord-005453-4057qib7 16456 32 . . . cord-005453-4057qib7 16457 1 Univariate Univariate NNP cord-005453-4057qib7 16457 2 analysis analysis NN cord-005453-4057qib7 16457 3 showed show VBD cord-005453-4057qib7 16457 4 that that IN cord-005453-4057qib7 16457 5 the the DT cord-005453-4057qib7 16457 6 hematopoietic hematopoietic JJ cord-005453-4057qib7 16457 7 cell cell NN cord-005453-4057qib7 16457 8 transplantation transplantation NN cord-005453-4057qib7 16457 9 comorbidity comorbidity NN cord-005453-4057qib7 16457 10 index(HCT index(HCT NNP cord-005453-4057qib7 16457 11 - - HYPH cord-005453-4057qib7 16457 12 CI CI NNP cord-005453-4057qib7 16457 13 ) ) -RRB- cord-005453-4057qib7 16457 14 and and CC cord-005453-4057qib7 16457 15 grade grade NN cord-005453-4057qib7 16457 16 III III NNP cord-005453-4057qib7 16457 17 - - HYPH cord-005453-4057qib7 16457 18 IV IV NNP cord-005453-4057qib7 16457 19 aGVHD aGVHD NNP cord-005453-4057qib7 16457 20 are be VBP cord-005453-4057qib7 16457 21 the the DT cord-005453-4057qib7 16457 22 high high JJ cord-005453-4057qib7 16457 23 risk risk NN cord-005453-4057qib7 16457 24 factors factor NNS cord-005453-4057qib7 16457 25 for for IN cord-005453-4057qib7 16457 26 OS(81.2±4.5 OS(81.2±4.5 NNP cord-005453-4057qib7 16457 27 % % NN cord-005453-4057qib7 16457 28 vs vs IN cord-005453-4057qib7 16457 29 62.8±10 62.8±10 CD cord-005453-4057qib7 16457 30 % % NN cord-005453-4057qib7 16457 31 , , , cord-005453-4057qib7 16457 32 P=0.027 p=0.027 JJ cord-005453-4057qib7 16457 33 and and CC cord-005453-4057qib7 16457 34 81.9±4.4 81.9±4.4 CD cord-005453-4057qib7 16457 35 % % NN cord-005453-4057qib7 16457 36 vs vs IN cord-005453-4057qib7 16457 37 51.1±11.8%,P 51.1±11.8%,p CD cord-005453-4057qib7 16457 38 < < XX cord-005453-4057qib7 16457 39 0.001 0.001 CD cord-005453-4057qib7 16457 40 ) ) -RRB- cord-005453-4057qib7 16457 41 . . . cord-005453-4057qib7 16458 1 Multivariate multivariate JJ cord-005453-4057qib7 16458 2 analysis analysis NN cord-005453-4057qib7 16458 3 demonstrated demonstrate VBD cord-005453-4057qib7 16458 4 that that IN cord-005453-4057qib7 16458 5 grade grade NN cord-005453-4057qib7 16458 6 III III NNP cord-005453-4057qib7 16458 7 - - HYPH cord-005453-4057qib7 16458 8 IV IV NNP cord-005453-4057qib7 16458 9 aGVHD aGVHD NNP cord-005453-4057qib7 16458 10 and and CC cord-005453-4057qib7 16458 11 HCT HCT NNP cord-005453-4057qib7 16458 12 - - HYPH cord-005453-4057qib7 16458 13 CI CI NNP cord-005453-4057qib7 16458 14 are be VBP cord-005453-4057qib7 16458 15 independent independent JJ cord-005453-4057qib7 16458 16 risk risk NN cord-005453-4057qib7 16458 17 factors factor NNS cord-005453-4057qib7 16458 18 for for IN cord-005453-4057qib7 16458 19 OS(HR=6.206 OS(HR=6.206 NNP cord-005453-4057qib7 16458 20 , , , cord-005453-4057qib7 16458 21 P p NN cord-005453-4057qib7 16458 22 < < XX cord-005453-4057qib7 16458 23 0.001 0.001 CD cord-005453-4057qib7 16458 24 , , , cord-005453-4057qib7 16458 25 95 95 CD cord-005453-4057qib7 16458 26 % % NN cord-005453-4057qib7 16459 1 CI:2.529~15.288 CI:2.529~15.288 NNP cord-005453-4057qib7 16459 2 and and CC cord-005453-4057qib7 16459 3 HR=2.651,P=0.025 HR=2.651,P=0.025 NNP cord-005453-4057qib7 16459 4 , , , cord-005453-4057qib7 16459 5 95%CI:1.127~6.232 95%ci:1.127~6.232 CD cord-005453-4057qib7 16459 6 ) ) -RRB- cord-005453-4057qib7 16459 7 . . . cord-005453-4057qib7 16460 1 Chemotherapy chemotherapy NN cord-005453-4057qib7 16460 2 before before IN cord-005453-4057qib7 16460 3 transplantation transplantation NN cord-005453-4057qib7 16460 4 did do VBD cord-005453-4057qib7 16460 5 not not RB cord-005453-4057qib7 16460 6 improve improve VB cord-005453-4057qib7 16460 7 OS OS NNP cord-005453-4057qib7 16460 8 or or CC cord-005453-4057qib7 16460 9 DFS DFS NNP cord-005453-4057qib7 16460 10 for for IN cord-005453-4057qib7 16460 11 patients patient NNS cord-005453-4057qib7 16460 12 with with IN cord-005453-4057qib7 16460 13 bone bone NN cord-005453-4057qib7 16460 14 marrow marrow NN cord-005453-4057qib7 16460 15 blast blast NN cord-005453-4057qib7 16460 16 cells cell NNS cord-005453-4057qib7 16460 17 more more JJR cord-005453-4057qib7 16460 18 than than IN cord-005453-4057qib7 16460 19 10 10 CD cord-005453-4057qib7 16460 20 % % NN cord-005453-4057qib7 16460 21 at at IN cord-005453-4057qib7 16460 22 the the DT cord-005453-4057qib7 16460 23 time time NN cord-005453-4057qib7 16460 24 of of IN cord-005453-4057qib7 16460 25 diagnosis diagnosis NN cord-005453-4057qib7 16460 26 . . . cord-005453-4057qib7 16461 1 Conclusions conclusion NNS cord-005453-4057qib7 16461 2 : : : cord-005453-4057qib7 16462 1 Allo Allo NNP cord-005453-4057qib7 16462 2 - - HYPH cord-005453-4057qib7 16462 3 HSCT HSCT NNP cord-005453-4057qib7 16462 4 is be VBZ cord-005453-4057qib7 16462 5 an an DT cord-005453-4057qib7 16462 6 effective effective JJ cord-005453-4057qib7 16462 7 treatment treatment NN cord-005453-4057qib7 16462 8 for for IN cord-005453-4057qib7 16462 9 MDS MDS NNP cord-005453-4057qib7 16462 10 patients patient NNS cord-005453-4057qib7 16462 11 of of IN cord-005453-4057qib7 16462 12 relatively relatively RB cord-005453-4057qib7 16462 13 high high JJ cord-005453-4057qib7 16462 14 - - HYPH cord-005453-4057qib7 16462 15 risk risk NN cord-005453-4057qib7 16462 16 groups group NNS cord-005453-4057qib7 16462 17 . . . cord-005453-4057qib7 16463 1 The the DT cord-005453-4057qib7 16463 2 physical physical JJ cord-005453-4057qib7 16463 3 condition condition NN cord-005453-4057qib7 16463 4 of of IN cord-005453-4057qib7 16463 5 the the DT cord-005453-4057qib7 16463 6 patients patient NNS cord-005453-4057qib7 16463 7 and and CC cord-005453-4057qib7 16463 8 occurrence occurrence NN cord-005453-4057qib7 16463 9 of of IN cord-005453-4057qib7 16463 10 aGVHD aGVHD NNP cord-005453-4057qib7 16463 11 are be VBP cord-005453-4057qib7 16463 12 independent independent JJ cord-005453-4057qib7 16463 13 risk risk NN cord-005453-4057qib7 16463 14 factors factor NNS cord-005453-4057qib7 16463 15 . . . cord-005453-4057qib7 16464 1 For for IN cord-005453-4057qib7 16464 2 intermediate intermediate JJ cord-005453-4057qib7 16464 3 and and CC cord-005453-4057qib7 16464 4 high high JJ cord-005453-4057qib7 16464 5 risk risk NN cord-005453-4057qib7 16464 6 IPSS IPSS NNP cord-005453-4057qib7 16464 7 - - HYPH cord-005453-4057qib7 16464 8 R R NNP cord-005453-4057qib7 16464 9 MDS MDS NNP cord-005453-4057qib7 16464 10 patients patient NNS cord-005453-4057qib7 16464 11 , , , cord-005453-4057qib7 16464 12 transplantation transplantation NN cord-005453-4057qib7 16464 13 before before IN cord-005453-4057qib7 16464 14 the the DT cord-005453-4057qib7 16464 15 disease disease NN cord-005453-4057qib7 16464 16 progressed progress VBD cord-005453-4057qib7 16464 17 into into IN cord-005453-4057qib7 16464 18 very very RB cord-005453-4057qib7 16464 19 high high JJ cord-005453-4057qib7 16464 20 risk risk NN cord-005453-4057qib7 16464 21 can can MD cord-005453-4057qib7 16464 22 achieve achieve VB cord-005453-4057qib7 16464 23 better well JJR cord-005453-4057qib7 16464 24 prognosis prognosis NN cord-005453-4057qib7 16464 25 , , , cord-005453-4057qib7 16464 26 high high JJ cord-005453-4057qib7 16464 27 - - HYPH cord-005453-4057qib7 16464 28 risk risk NN cord-005453-4057qib7 16464 29 group group NN cord-005453-4057qib7 16464 30 can can MD cord-005453-4057qib7 16464 31 still still RB cord-005453-4057qib7 16464 32 benefit benefit VB cord-005453-4057qib7 16464 33 from from IN cord-005453-4057qib7 16464 34 rebound rebound NN cord-005453-4057qib7 16464 35 GvHD gvhd NN cord-005453-4057qib7 16464 36 after after IN cord-005453-4057qib7 16464 37 CNI CNI NNP cord-005453-4057qib7 16464 38 tapering tapering NNP cord-005453-4057qib7 16464 39 which which WDT cord-005453-4057qib7 16464 40 was be VBD cord-005453-4057qib7 16464 41 promptly promptly RB cord-005453-4057qib7 16464 42 responsive responsive JJ cord-005453-4057qib7 16464 43 to to IN cord-005453-4057qib7 16464 44 treatment treatment NN cord-005453-4057qib7 16464 45 steroids steroid NNS cord-005453-4057qib7 16464 46 , , , cord-005453-4057qib7 16464 47 FK506 FK506 NNP cord-005453-4057qib7 16464 48 and and CC cord-005453-4057qib7 16464 49 ECP ECP NNP cord-005453-4057qib7 16464 50 . . . cord-005453-4057qib7 16465 1 Aa Aa NNP cord-005453-4057qib7 16466 1 one one CD cord-005453-4057qib7 16466 2 year year NN cord-005453-4057qib7 16466 3 after after IN cord-005453-4057qib7 16466 4 SCT SCT NNP cord-005453-4057qib7 16466 5 12/13 12/13 CD cord-005453-4057qib7 16466 6 patients patient NNS cord-005453-4057qib7 16466 7 were be VBD cord-005453-4057qib7 16466 8 without without IN cord-005453-4057qib7 16466 9 GvHD GvHD NNP cord-005453-4057qib7 16466 10 and and CC cord-005453-4057qib7 16466 11 off off IN cord-005453-4057qib7 16466 12 all all DT cord-005453-4057qib7 16466 13 immunosuppression immunosuppression NN cord-005453-4057qib7 16466 14 while while IN cord-005453-4057qib7 16466 15 one one CD cord-005453-4057qib7 16466 16 single single JJ cord-005453-4057qib7 16466 17 patient patient NN cord-005453-4057qib7 16466 18 was be VBD cord-005453-4057qib7 16466 19 still still RB cord-005453-4057qib7 16466 20 on on IN cord-005453-4057qib7 16466 21 taper taper NN cord-005453-4057qib7 16466 22 of of IN cord-005453-4057qib7 16466 23 immunosuppressant immunosuppressant NN cord-005453-4057qib7 16466 24 after after IN cord-005453-4057qib7 16466 25 rebound rebound NN cord-005453-4057qib7 16466 26 acute acute JJ cord-005453-4057qib7 16466 27 GvHD gvhd NN cord-005453-4057qib7 16466 28 . . . cord-005453-4057qib7 16467 1 No no DT cord-005453-4057qib7 16467 2 chronic chronic JJ cord-005453-4057qib7 16467 3 GvHD gvhd NN cord-005453-4057qib7 16467 4 occurred occur VBD cord-005453-4057qib7 16467 5 . . . cord-005453-4057qib7 16468 1 SCTrelated sctrelated JJ cord-005453-4057qib7 16468 2 toxicity toxicity NN cord-005453-4057qib7 16468 3 was be VBD cord-005453-4057qib7 16468 4 common common JJ cord-005453-4057qib7 16468 5 with with IN cord-005453-4057qib7 16468 6 mucositis mucositis NNP cord-005453-4057qib7 16468 7 in in IN cord-005453-4057qib7 16468 8 all all DT cord-005453-4057qib7 16468 9 patients patient NNS cord-005453-4057qib7 16468 10 ( ( -LRB- cord-005453-4057qib7 16468 11 WHO who WP cord-005453-4057qib7 16468 12 grade grade NN cord-005453-4057qib7 16468 13 4 4 CD cord-005453-4057qib7 16468 14 : : : cord-005453-4057qib7 16468 15 n=5 n=5 NNP cord-005453-4057qib7 16468 16 ) ) -RRB- cord-005453-4057qib7 16468 17 , , , cord-005453-4057qib7 16468 18 elevated elevated JJ cord-005453-4057qib7 16468 19 liver liver NN cord-005453-4057qib7 16468 20 enzymes enzyme NNS cord-005453-4057qib7 16468 21 ( ( -LRB- cord-005453-4057qib7 16468 22 ≥grade ≥grade IN cord-005453-4057qib7 16468 23 3 3 CD cord-005453-4057qib7 16468 24 : : : cord-005453-4057qib7 16468 25 n=9 n=9 NN cord-005453-4057qib7 16468 26 ) ) -RRB- cord-005453-4057qib7 16468 27 and and CC cord-005453-4057qib7 16468 28 impaired impair VBN cord-005453-4057qib7 16468 29 renal renal JJ cord-005453-4057qib7 16468 30 function function NN cord-005453-4057qib7 16468 31 ( ( -LRB- cord-005453-4057qib7 16468 32 GFR GFR NNP cord-005453-4057qib7 16468 33 40 40 CD cord-005453-4057qib7 16468 34 - - HYPH cord-005453-4057qib7 16468 35 60ml 60ml NN cord-005453-4057qib7 16468 36 / / SYM cord-005453-4057qib7 16468 37 min min NN cord-005453-4057qib7 16468 38 : : : cord-005453-4057qib7 16468 39 n=8 n=8 NN cord-005453-4057qib7 16468 40 ) ) -RRB- cord-005453-4057qib7 16468 41 . . . cord-005453-4057qib7 16469 1 Five five CD cord-005453-4057qib7 16469 2 patients patient NNS cord-005453-4057qib7 16469 3 developed develop VBD cord-005453-4057qib7 16469 4 neurologic neurologic JJ cord-005453-4057qib7 16469 5 symptoms symptom NNS cord-005453-4057qib7 16469 6 ( ( -LRB- cord-005453-4057qib7 16469 7 seizures seizure NNS cord-005453-4057qib7 16469 8 n=2 n=2 NNS cord-005453-4057qib7 16469 9 , , , cord-005453-4057qib7 16469 10 PRES PRES NNP cord-005453-4057qib7 16469 11 n=1 n=1 NNP cord-005453-4057qib7 16469 12 , , , cord-005453-4057qib7 16469 13 pseudotumor pseudotumor NN cord-005453-4057qib7 16469 14 cerebri cerebri NNP cord-005453-4057qib7 16469 15 n=2 n=2 NNS cord-005453-4057qib7 16469 16 ) ) -RRB- cord-005453-4057qib7 16469 17 which which WDT cord-005453-4057qib7 16469 18 all all DT cord-005453-4057qib7 16469 19 resolved resolve VBD cord-005453-4057qib7 16469 20 without without IN cord-005453-4057qib7 16469 21 sequelae sequela NNS cord-005453-4057qib7 16469 22 . . . cord-005453-4057qib7 16470 1 Overall overall JJ cord-005453-4057qib7 16470 2 survival survival NN cord-005453-4057qib7 16470 3 and and CC cord-005453-4057qib7 16470 4 transfusion transfusion NN cord-005453-4057qib7 16470 5 - - HYPH cord-005453-4057qib7 16470 6 free free JJ cord-005453-4057qib7 16470 7 survival survival NN cord-005453-4057qib7 16470 8 was be VBD cord-005453-4057qib7 16470 9 100 100 CD cord-005453-4057qib7 16470 10 % % NN cord-005453-4057qib7 16470 11 with with IN cord-005453-4057qib7 16470 12 a a DT cord-005453-4057qib7 16470 13 median median JJ cord-005453-4057qib7 16470 14 observation observation NN cord-005453-4057qib7 16470 15 time time NN cord-005453-4057qib7 16470 16 of of IN cord-005453-4057qib7 16470 17 5 5 CD cord-005453-4057qib7 16470 18 ( ( -LRB- cord-005453-4057qib7 16470 19 2 2 CD cord-005453-4057qib7 16470 20 - - SYM cord-005453-4057qib7 16470 21 8 8 CD cord-005453-4057qib7 16470 22 ) ) -RRB- cord-005453-4057qib7 16470 23 years year NNS cord-005453-4057qib7 16470 24 . . . cord-005453-4057qib7 16471 1 Conclusions conclusion NNS cord-005453-4057qib7 16471 2 : : : cord-005453-4057qib7 16471 3 4 4 CD cord-005453-4057qib7 16471 4 . . . cord-005453-4057qib7 16472 1 Treosulfan Treosulfan NNP cord-005453-4057qib7 16472 2 - - HYPH cord-005453-4057qib7 16472 3 based base VBN cord-005453-4057qib7 16472 4 conditioning conditioning NN cord-005453-4057qib7 16472 5 followed follow VBN cord-005453-4057qib7 16472 6 by by IN cord-005453-4057qib7 16472 7 SCT SCT NNP cord-005453-4057qib7 16472 8 from from IN cord-005453-4057qib7 16472 9 HLA HLA NNP cord-005453-4057qib7 16472 10 - - HYPH cord-005453-4057qib7 16472 11 matched match VBN cord-005453-4057qib7 16472 12 related related JJ cord-005453-4057qib7 16472 13 or or CC cord-005453-4057qib7 16472 14 unrelated unrelated JJ cord-005453-4057qib7 16472 15 donors donor NNS cord-005453-4057qib7 16472 16 represents represent VBZ cord-005453-4057qib7 16472 17 a a DT cord-005453-4057qib7 16472 18 highly highly RB cord-005453-4057qib7 16472 19 efficacious efficacious JJ cord-005453-4057qib7 16472 20 treatment treatment NN cord-005453-4057qib7 16472 21 approach approach NN cord-005453-4057qib7 16472 22 for for IN cord-005453-4057qib7 16472 23 children child NNS cord-005453-4057qib7 16472 24 , , , cord-005453-4057qib7 16472 25 adolescents adolescent NNS cord-005453-4057qib7 16472 26 and and CC cord-005453-4057qib7 16472 27 young young JJ cord-005453-4057qib7 16472 28 adults adult NNS cord-005453-4057qib7 16472 29 with with IN cord-005453-4057qib7 16472 30 TDT TDT NNP cord-005453-4057qib7 16472 31 and and CC cord-005453-4057qib7 16472 32 exhibits exhibit VBZ cord-005453-4057qib7 16472 33 an an DT cord-005453-4057qib7 16472 34 acceptable acceptable JJ cord-005453-4057qib7 16472 35 but but CC cord-005453-4057qib7 16472 36 not not RB cord-005453-4057qib7 16472 37 negligible negligible JJ cord-005453-4057qib7 16472 38 safety safety NN cord-005453-4057qib7 16472 39 profile profile NN cord-005453-4057qib7 16472 40 . . . cord-005453-4057qib7 16473 1 An an DT cord-005453-4057qib7 16473 2 individual individual JJ cord-005453-4057qib7 16473 3 risk risk NN cord-005453-4057qib7 16473 4 - - HYPH cord-005453-4057qib7 16473 5 benefit benefit NN cord-005453-4057qib7 16473 6 assessment assessment NN cord-005453-4057qib7 16473 7 incorporating incorporate VBG cord-005453-4057qib7 16473 8 hazards hazard NNS cord-005453-4057qib7 16473 9 such such JJ cord-005453-4057qib7 16473 10 as as IN cord-005453-4057qib7 16473 11 secondary secondary JJ cord-005453-4057qib7 16473 12 graft graft NN cord-005453-4057qib7 16473 13 failure failure NN cord-005453-4057qib7 16473 14 , , , cord-005453-4057qib7 16473 15 GvHD gvhd NN cord-005453-4057qib7 16473 16 and and CC cord-005453-4057qib7 16473 17 long long JJ cord-005453-4057qib7 16473 18 - - HYPH cord-005453-4057qib7 16473 19 term term NN cord-005453-4057qib7 16473 20 toxicity toxicity NN cord-005453-4057qib7 16473 21 including include VBG cord-005453-4057qib7 16473 22 infertility infertility NN cord-005453-4057qib7 16473 23 and and CC cord-005453-4057qib7 16473 24 2 2 CD cord-005453-4057qib7 16473 25 nd nd NNP cord-005453-4057qib7 16473 26 malignancy malignancy NN cord-005453-4057qib7 16473 27 has have VBZ cord-005453-4057qib7 16473 28 to to TO cord-005453-4057qib7 16473 29 be be VB cord-005453-4057qib7 16473 30 executed execute VBN cord-005453-4057qib7 16473 31 in in IN cord-005453-4057qib7 16473 32 the the DT cord-005453-4057qib7 16473 33 informed informed JJ cord-005453-4057qib7 16473 34 consent consent NN cord-005453-4057qib7 16473 35 process process NN cord-005453-4057qib7 16473 36 for for IN cord-005453-4057qib7 16473 37 every every DT cord-005453-4057qib7 16473 38 patient patient NN cord-005453-4057qib7 16473 39 and and CC cord-005453-4057qib7 16473 40 his -PRON- PRP$ cord-005453-4057qib7 16473 41 / / SYM cord-005453-4057qib7 16473 42 her -PRON- PRP$ cord-005453-4057qib7 16473 43 guardians guardian NNS cord-005453-4057qib7 16473 44 . . . cord-005453-4057qib7 16474 1 Disclosure disclosure NN cord-005453-4057qib7 16474 2 : : : cord-005453-4057qib7 16474 3 " " `` cord-005453-4057qib7 16474 4 Nothing nothing NN cord-005453-4057qib7 16474 5 to to TO cord-005453-4057qib7 16474 6 declare declare VB cord-005453-4057qib7 16474 7 " " `` cord-005453-4057qib7 16474 8 P740 P740 NNP cord-005453-4057qib7 16474 9 Abstract Abstract NNP cord-005453-4057qib7 16474 10 already already RB cord-005453-4057qib7 16474 11 published publish VBN cord-005453-4057qib7 16474 12 . . . cord-005453-4057qib7 16475 1 Early early JJ cord-005453-4057qib7 16475 2 iron iron NN cord-005453-4057qib7 16475 3 chelation chelation NN cord-005453-4057qib7 16475 4 with with IN cord-005453-4057qib7 16475 5 deferasirox deferasirox NNP cord-005453-4057qib7 16475 6 might may MD cord-005453-4057qib7 16475 7 prevent prevent VB cord-005453-4057qib7 16475 8 relapse relapse NN cord-005453-4057qib7 16475 9 after after IN cord-005453-4057qib7 16475 10 busulfan busulfan NN cord-005453-4057qib7 16475 11 plus plus CC cord-005453-4057qib7 16475 12 fludarabine fludarabine NN cord-005453-4057qib7 16475 13 and and CC cord-005453-4057qib7 16475 14 ATG ATG NNP cord-005453-4057qib7 16475 15 as as IN cord-005453-4057qib7 16475 16 a a DT cord-005453-4057qib7 16475 17 myeloablative myeloablative JJ cord-005453-4057qib7 16475 18 conditioning conditioning NN cord-005453-4057qib7 16475 19 for for IN cord-005453-4057qib7 16475 20 HLA HLA NNP cord-005453-4057qib7 16475 21 - - HYPH cord-005453-4057qib7 16475 22 identical identical JJ cord-005453-4057qib7 16475 23 sibling sibling NN cord-005453-4057qib7 16475 24 allogeneic allogeneic NN cord-005453-4057qib7 16475 25 HCT hct NN cord-005453-4057qib7 16475 26 in in IN cord-005453-4057qib7 16475 27 AML AML NNP cord-005453-4057qib7 16475 28 Results result NNS cord-005453-4057qib7 16475 29 : : : cord-005453-4057qib7 16475 30 We -PRON- PRP cord-005453-4057qib7 16475 31 show show VBP cord-005453-4057qib7 16475 32 an an DT cord-005453-4057qib7 16475 33 excellent excellent JJ cord-005453-4057qib7 16475 34 concordance concordance NN cord-005453-4057qib7 16475 35 between between IN cord-005453-4057qib7 16475 36 chimerism chimerism NN cord-005453-4057qib7 16475 37 assessment assessment NN cord-005453-4057qib7 16475 38 on on IN cord-005453-4057qib7 16475 39 Bio Bio NNP cord-005453-4057qib7 16475 40 - - HYPH cord-005453-4057qib7 16475 41 Rad Rad NNP cord-005453-4057qib7 16475 42 and and CC cord-005453-4057qib7 16475 43 3 3 CD cord-005453-4057qib7 16475 44 D d NN cord-005453-4057qib7 16475 45 platforms platform NNS cord-005453-4057qib7 16475 46 over over IN cord-005453-4057qib7 16475 47 the the DT cord-005453-4057qib7 16475 48 complete complete JJ cord-005453-4057qib7 16475 49 range range NN cord-005453-4057qib7 16475 50 of of IN cord-005453-4057qib7 16475 51 mixture mixture NN cord-005453-4057qib7 16475 52 ratios ratio NNS cord-005453-4057qib7 16476 1 ( ( -LRB- cord-005453-4057qib7 16476 2 R r NN cord-005453-4057qib7 16476 3 2 2 CD cord-005453-4057qib7 16476 4 > > XX cord-005453-4057qib7 16476 5 0,9 0,9 CD cord-005453-4057qib7 16476 6 ) ) -RRB- cord-005453-4057qib7 16477 1 and and CC cord-005453-4057qib7 16477 2 proof proof NN cord-005453-4057qib7 16477 3 the the DT cord-005453-4057qib7 16477 4 lower low JJR cord-005453-4057qib7 16477 5 detection detection NN cord-005453-4057qib7 16477 6 limit limit NN cord-005453-4057qib7 16477 7 ( ( -LRB- cord-005453-4057qib7 16477 8 0,1 0,1 CD cord-005453-4057qib7 16477 9 % % NN cord-005453-4057qib7 16477 10 ) ) -RRB- cord-005453-4057qib7 16477 11 compared compare VBN cord-005453-4057qib7 16477 12 to to IN cord-005453-4057qib7 16477 13 STR STR NNP cord-005453-4057qib7 16477 14 - - HYPH cord-005453-4057qib7 16477 15 PCR.Conclusions pcr.conclusion NNS cord-005453-4057qib7 16477 16 : : : cord-005453-4057qib7 16478 1 Our -PRON- PRP$ cord-005453-4057qib7 16478 2 results result NNS cord-005453-4057qib7 16478 3 promote promote VBP cord-005453-4057qib7 16478 4 the the DT cord-005453-4057qib7 16478 5 transfer transfer NN cord-005453-4057qib7 16478 6 of of IN cord-005453-4057qib7 16478 7 the the DT cord-005453-4057qib7 16478 8 established establish VBN cord-005453-4057qib7 16478 9 Mentype Mentype NNP cord-005453-4057qib7 16478 10 assay assay NN cord-005453-4057qib7 16478 11 to to IN cord-005453-4057qib7 16478 12 a a DT cord-005453-4057qib7 16478 13 more more RBR cord-005453-4057qib7 16478 14 diverse diverse JJ cord-005453-4057qib7 16478 15 instrument instrument NN cord-005453-4057qib7 16478 16 portfolio portfolio NN cord-005453-4057qib7 16478 17 . . . cord-005453-4057qib7 16479 1 That that DT cord-005453-4057qib7 16479 2 will will MD cord-005453-4057qib7 16479 3 allow allow VB cord-005453-4057qib7 16479 4 to to TO cord-005453-4057qib7 16479 5 implement implement VB cord-005453-4057qib7 16479 6 the the DT cord-005453-4057qib7 16479 7 analysis analysis NN cord-005453-4057qib7 16479 8 of of IN cord-005453-4057qib7 16479 9 patient patient NN cord-005453-4057qib7 16479 10 and and CC cord-005453-4057qib7 16479 11 donor donor NN cord-005453-4057qib7 16479 12 hematopoiesis hematopoiesis NN cord-005453-4057qib7 16479 13 by by IN cord-005453-4057qib7 16479 14 digital digital JJ cord-005453-4057qib7 16479 15 PCR PCR NNP cord-005453-4057qib7 16479 16 methods method NNS cord-005453-4057qib7 16479 17 in in IN cord-005453-4057qib7 16479 18 our -PRON- PRP$ cord-005453-4057qib7 16479 19 lab lab NN cord-005453-4057qib7 16479 20 . . . cord-005453-4057qib7 16480 1 Disclosure disclosure NN cord-005453-4057qib7 16480 2 Background background NN cord-005453-4057qib7 16480 3 : : : cord-005453-4057qib7 16480 4 With with IN cord-005453-4057qib7 16480 5 the the DT cord-005453-4057qib7 16480 6 immense immense JJ cord-005453-4057qib7 16480 7 progress progress NN cord-005453-4057qib7 16480 8 in in IN cord-005453-4057qib7 16480 9 therapeutic therapeutic JJ cord-005453-4057qib7 16480 10 regimens regimen NNS cord-005453-4057qib7 16480 11 in in IN cord-005453-4057qib7 16480 12 pediatric pediatric JJ cord-005453-4057qib7 16480 13 oncology oncology NN cord-005453-4057qib7 16480 14 and and CC cord-005453-4057qib7 16480 15 stem stem NN cord-005453-4057qib7 16480 16 cell cell NN cord-005453-4057qib7 16480 17 transplantation transplantation NN cord-005453-4057qib7 16480 18 the the DT cord-005453-4057qib7 16480 19 survivor survivor NN cord-005453-4057qib7 16480 20 rates rate NNS cord-005453-4057qib7 16480 21 increased increase VBD cord-005453-4057qib7 16480 22 up up RB cord-005453-4057qib7 16480 23 to to TO cord-005453-4057qib7 16480 24 80 80 CD cord-005453-4057qib7 16480 25 % % NN cord-005453-4057qib7 16480 26 . . . cord-005453-4057qib7 16481 1 At at IN cord-005453-4057qib7 16481 2 the the DT cord-005453-4057qib7 16481 3 same same JJ cord-005453-4057qib7 16481 4 time time NN cord-005453-4057qib7 16481 5 the the DT cord-005453-4057qib7 16481 6 field field NN cord-005453-4057qib7 16481 7 of of IN cord-005453-4057qib7 16481 8 reproductive reproductive JJ cord-005453-4057qib7 16481 9 medicine medicine NN cord-005453-4057qib7 16481 10 has have VBZ cord-005453-4057qib7 16481 11 achieved achieve VBN cord-005453-4057qib7 16481 12 substantial substantial JJ cord-005453-4057qib7 16481 13 advances advance NNS cord-005453-4057qib7 16481 14 to to TO cord-005453-4057qib7 16481 15 offer offer VB cord-005453-4057qib7 16481 16 potential potential JJ cord-005453-4057qib7 16481 17 options option NNS cord-005453-4057qib7 16481 18 for for IN cord-005453-4057qib7 16481 19 fertility fertility NN cord-005453-4057qib7 16481 20 preservation preservation NN cord-005453-4057qib7 16481 21 . . . cord-005453-4057qib7 16482 1 Therefore therefore RB cord-005453-4057qib7 16482 2 it -PRON- PRP cord-005453-4057qib7 16482 3 is be VBZ cord-005453-4057qib7 16482 4 of of IN cord-005453-4057qib7 16482 5 great great JJ cord-005453-4057qib7 16482 6 importance importance NN cord-005453-4057qib7 16482 7 to to TO cord-005453-4057qib7 16482 8 implement implement VB cord-005453-4057qib7 16482 9 fertility fertility NN cord-005453-4057qib7 16482 10 counseling counseling NN cord-005453-4057qib7 16482 11 and and CC cord-005453-4057qib7 16482 12 fertility fertility NN cord-005453-4057qib7 16482 13 preserving preserve VBG cord-005453-4057qib7 16482 14 ( ( -LRB- cord-005453-4057qib7 16482 15 FP FP NNP cord-005453-4057qib7 16482 16 ) ) -RRB- cord-005453-4057qib7 16482 17 procedures procedure NNS cord-005453-4057qib7 16482 18 for for IN cord-005453-4057qib7 16482 19 patients patient NNS cord-005453-4057qib7 16482 20 facing face VBG cord-005453-4057qib7 16482 21 gonadotoxic gonadotoxic JJ cord-005453-4057qib7 16482 22 therapy therapy NN cord-005453-4057qib7 16482 23 . . . cord-005453-4057qib7 16483 1 In in IN cord-005453-4057qib7 16483 2 the the DT cord-005453-4057qib7 16483 3 report report NN cord-005453-4057qib7 16483 4 on on IN cord-005453-4057qib7 16483 5 the the DT cord-005453-4057qib7 16483 6 expert expert NN cord-005453-4057qib7 16483 7 meeting meeting NN cord-005453-4057qib7 16483 8 of of IN cord-005453-4057qib7 16483 9 the the DT cord-005453-4057qib7 16483 10 Paediatric Paediatric NNP cord-005453-4057qib7 16483 11 Diseases Diseases NNPS cord-005453-4057qib7 16483 12 Working Working NNP cord-005453-4057qib7 16483 13 Party Party NNP cord-005453-4057qib7 16483 14 ( ( -LRB- cord-005453-4057qib7 16483 15 PDWP PDWP NNP cord-005453-4057qib7 16483 16 ) ) -RRB- cord-005453-4057qib7 16483 17 of of IN cord-005453-4057qib7 16483 18 the the DT cord-005453-4057qib7 16483 19 EBMT EBMT NNP cord-005453-4057qib7 16483 20 in in IN cord-005453-4057qib7 16483 21 2017 2017 CD cord-005453-4057qib7 16483 22 counseling counseling NN cord-005453-4057qib7 16483 23 related relate VBN cord-005453-4057qib7 16483 24 to to IN cord-005453-4057qib7 16483 25 FP FP NNP cord-005453-4057qib7 16483 26 opportunities opportunity NNS cord-005453-4057qib7 16483 27 should should MD cord-005453-4057qib7 16483 28 be be VB cord-005453-4057qib7 16483 29 offered offer VBN cord-005453-4057qib7 16483 30 to to IN cord-005453-4057qib7 16483 31 each each DT cord-005453-4057qib7 16483 32 patient patient JJ cord-005453-4057qib7 16483 33 receiving receive VBG cord-005453-4057qib7 16483 34 stem stem NN cord-005453-4057qib7 16483 35 cell cell NN cord-005453-4057qib7 16483 36 transplantation transplantation NN cord-005453-4057qib7 16483 37 ( ( -LRB- cord-005453-4057qib7 16483 38 SCT SCT NNP cord-005453-4057qib7 16483 39 ) ) -RRB- cord-005453-4057qib7 16483 40 , , , cord-005453-4057qib7 16483 41 as as IN cord-005453-4057qib7 16483 42 part part NN cord-005453-4057qib7 16483 43 of of IN cord-005453-4057qib7 16483 44 the the DT cord-005453-4057qib7 16483 45 pre pre JJ cord-005453-4057qib7 16483 46 - - JJ cord-005453-4057qib7 16483 47 SCT sct JJ cord-005453-4057qib7 16483 48 workup workup NN cord-005453-4057qib7 16483 49 by by IN cord-005453-4057qib7 16483 50 a a DT cord-005453-4057qib7 16483 51 dedicated dedicated JJ cord-005453-4057qib7 16483 52 and and CC cord-005453-4057qib7 16483 53 trained trained JJ cord-005453-4057qib7 16483 54 team team NN cord-005453-4057qib7 16483 55 . . . cord-005453-4057qib7 16484 1 Yet yet CC cord-005453-4057qib7 16484 2 there there EX cord-005453-4057qib7 16484 3 many many JJ cord-005453-4057qib7 16484 4 medical medical JJ cord-005453-4057qib7 16484 5 , , , cord-005453-4057qib7 16484 6 ethical ethical JJ cord-005453-4057qib7 16484 7 , , , cord-005453-4057qib7 16484 8 structural structural JJ cord-005453-4057qib7 16484 9 and and CC cord-005453-4057qib7 16484 10 financial financial JJ cord-005453-4057qib7 16484 11 issues issue NNS cord-005453-4057qib7 16484 12 to to TO cord-005453-4057qib7 16484 13 consider consider VB cord-005453-4057qib7 16484 14 and and CC cord-005453-4057qib7 16484 15 overcome overcome VB cord-005453-4057qib7 16484 16 . . . cord-005453-4057qib7 16485 1 We -PRON- PRP cord-005453-4057qib7 16485 2 describe describe VBP cord-005453-4057qib7 16485 3 the the DT cord-005453-4057qib7 16485 4 setting setting NN cord-005453-4057qib7 16485 5 up up RP cord-005453-4057qib7 16485 6 process process NN cord-005453-4057qib7 16485 7 to to TO cord-005453-4057qib7 16485 8 enable enable VB cord-005453-4057qib7 16485 9 fertility fertility NN cord-005453-4057qib7 16485 10 counseling counsel VBG cord-005453-4057qib7 16485 11 for for IN cord-005453-4057qib7 16485 12 all all DT cord-005453-4057qib7 16485 13 children child NNS cord-005453-4057qib7 16485 14 with with IN cord-005453-4057qib7 16485 15 newly newly RB cord-005453-4057qib7 16485 16 diagnosed diagnose VBN cord-005453-4057qib7 16485 17 cancer cancer NN cord-005453-4057qib7 16485 18 or or CC cord-005453-4057qib7 16485 19 those those DT cord-005453-4057qib7 16485 20 facing face VBG cord-005453-4057qib7 16485 21 stem stem NN cord-005453-4057qib7 16485 22 cell cell NN cord-005453-4057qib7 16485 23 transplantation transplantation NN cord-005453-4057qib7 16485 24 for for IN cord-005453-4057qib7 16485 25 malignant malignant JJ cord-005453-4057qib7 16485 26 and and CC cord-005453-4057qib7 16485 27 nonmalignant nonmalignant JJ cord-005453-4057qib7 16485 28 diseases disease NNS cord-005453-4057qib7 16485 29 in in IN cord-005453-4057qib7 16485 30 our -PRON- PRP$ cord-005453-4057qib7 16485 31 department department NN cord-005453-4057qib7 16485 32 of of IN cord-005453-4057qib7 16485 33 pediatric pediatric NNP cord-005453-4057qib7 16485 34 oncology oncology NNP cord-005453-4057qib7 16485 35 and and CC cord-005453-4057qib7 16485 36 immunology immunology NN cord-005453-4057qib7 16485 37 / / SYM cord-005453-4057qib7 16485 38 stem stem NN cord-005453-4057qib7 16485 39 cell cell NN cord-005453-4057qib7 16485 40 transplantation transplantation NN cord-005453-4057qib7 16485 41 . . . cord-005453-4057qib7 16486 1 Methods method NNS cord-005453-4057qib7 16486 2 : : : cord-005453-4057qib7 16486 3 At at IN cord-005453-4057qib7 16486 4 our -PRON- PRP$ cord-005453-4057qib7 16486 5 tertiary tertiary JJ cord-005453-4057qib7 16486 6 care care NN cord-005453-4057qib7 16486 7 center center NN cord-005453-4057qib7 16486 8 we -PRON- PRP cord-005453-4057qib7 16486 9 assembled assemble VBD cord-005453-4057qib7 16486 10 a a DT cord-005453-4057qib7 16486 11 multidisciplinary multidisciplinary JJ cord-005453-4057qib7 16486 12 team team NN cord-005453-4057qib7 16486 13 involved involve VBN cord-005453-4057qib7 16486 14 in in IN cord-005453-4057qib7 16486 15 fertility fertility NN cord-005453-4057qib7 16486 16 preservation preservation NN cord-005453-4057qib7 16486 17 ( ( -LRB- cord-005453-4057qib7 16486 18 pediatric pediatric JJ cord-005453-4057qib7 16486 19 hematology hematology NN cord-005453-4057qib7 16486 20 / / SYM cord-005453-4057qib7 16486 21 oncology oncology NN cord-005453-4057qib7 16486 22 , , , cord-005453-4057qib7 16486 23 pediatric pediatric JJ cord-005453-4057qib7 16486 24 immunology/ immunology/ NN cord-005453-4057qib7 16486 25 stem stem NN cord-005453-4057qib7 16486 26 cell cell NN cord-005453-4057qib7 16486 27 transplantation transplantation NN cord-005453-4057qib7 16486 28 , , , cord-005453-4057qib7 16486 29 reproductive reproductive JJ cord-005453-4057qib7 16486 30 medicine medicine NN cord-005453-4057qib7 16486 31 , , , cord-005453-4057qib7 16486 32 andrology andrology NN cord-005453-4057qib7 16486 33 , , , cord-005453-4057qib7 16486 34 psychology psychology NN cord-005453-4057qib7 16486 35 and and CC cord-005453-4057qib7 16486 36 pediatric pediatric JJ cord-005453-4057qib7 16486 37 surgery surgery NN cord-005453-4057qib7 16486 38 ) ) -RRB- cord-005453-4057qib7 16486 39 . . . cord-005453-4057qib7 16487 1 We -PRON- PRP cord-005453-4057qib7 16487 2 developed develop VBD cord-005453-4057qib7 16487 3 an an DT cord-005453-4057qib7 16487 4 internal internal JJ cord-005453-4057qib7 16487 5 grading grading NN cord-005453-4057qib7 16487 6 system system NN cord-005453-4057qib7 16487 7 for for IN cord-005453-4057qib7 16487 8 recommendations recommendation NNS cord-005453-4057qib7 16487 9 regarding regard VBG cord-005453-4057qib7 16487 10 fertility fertility NN cord-005453-4057qib7 16487 11 preservation preservation NN cord-005453-4057qib7 16487 12 based base VBN cord-005453-4057qib7 16487 13 on on IN cord-005453-4057qib7 16487 14 the the DT cord-005453-4057qib7 16487 15 current current JJ cord-005453-4057qib7 16487 16 recommendations recommendation NNS cord-005453-4057qib7 16487 17 for for IN cord-005453-4057qib7 16487 18 fertility fertility NN cord-005453-4057qib7 16487 19 preservation preservation NN cord-005453-4057qib7 16487 20 of of IN cord-005453-4057qib7 16487 21 leading lead VBG cord-005453-4057qib7 16487 22 societies society NNS cord-005453-4057qib7 16487 23 in in IN cord-005453-4057qib7 16487 24 this this DT cord-005453-4057qib7 16487 25 field field NN cord-005453-4057qib7 16487 26 like like IN cord-005453-4057qib7 16487 27 EBMT EBMT NNP cord-005453-4057qib7 16487 28 , , , cord-005453-4057qib7 16487 29 GPOH GPOH NNP cord-005453-4057qib7 16487 30 and and CC cord-005453-4057qib7 16487 31 DGGG DGGG NNP cord-005453-4057qib7 16487 32 . . . cord-005453-4057qib7 16488 1 It -PRON- PRP cord-005453-4057qib7 16488 2 is be VBZ cord-005453-4057qib7 16488 3 important important JJ cord-005453-4057qib7 16488 4 to to TO cord-005453-4057qib7 16488 5 find find VB cord-005453-4057qib7 16488 6 a a DT cord-005453-4057qib7 16488 7 consensus consensus NN cord-005453-4057qib7 16488 8 within within IN cord-005453-4057qib7 16488 9 the the DT cord-005453-4057qib7 16488 10 team team NN cord-005453-4057qib7 16488 11 for for IN cord-005453-4057qib7 16488 12 the the DT cord-005453-4057qib7 16488 13 counseling counseling NN cord-005453-4057qib7 16488 14 to to TO cord-005453-4057qib7 16488 15 ensure ensure VB cord-005453-4057qib7 16488 16 reliable reliable JJ cord-005453-4057qib7 16488 17 counseling counseling NN cord-005453-4057qib7 16488 18 . . . cord-005453-4057qib7 16489 1 The the DT cord-005453-4057qib7 16489 2 third third JJ cord-005453-4057qib7 16489 3 step step NN cord-005453-4057qib7 16489 4 is be VBZ cord-005453-4057qib7 16489 5 to to TO cord-005453-4057qib7 16489 6 implement implement VB cord-005453-4057qib7 16489 7 structures structure NNS cord-005453-4057qib7 16489 8 needed need VBN cord-005453-4057qib7 16489 9 for for IN cord-005453-4057qib7 16489 10 fertility fertility NN cord-005453-4057qib7 16489 11 counseling counseling NN cord-005453-4057qib7 16489 12 and and CC cord-005453-4057qib7 16489 13 performance performance NN cord-005453-4057qib7 16489 14 of of IN cord-005453-4057qib7 16489 15 invasive invasive JJ cord-005453-4057qib7 16489 16 procedures procedure NNS cord-005453-4057qib7 16489 17 including include VBG cord-005453-4057qib7 16489 18 legal legal JJ cord-005453-4057qib7 16489 19 aspects aspect NNS cord-005453-4057qib7 16489 20 ( ( -LRB- cord-005453-4057qib7 16489 21 AMG AMG NNP cord-005453-4057qib7 16489 22 ) ) -RRB- cord-005453-4057qib7 16489 23 . . . cord-005453-4057qib7 16490 1 A a DT cord-005453-4057qib7 16490 2 detailed detailed JJ cord-005453-4057qib7 16490 3 description description NN cord-005453-4057qib7 16490 4 of of IN cord-005453-4057qib7 16490 5 this this DT cord-005453-4057qib7 16490 6 process process NN cord-005453-4057qib7 16490 7 is be VBZ cord-005453-4057qib7 16490 8 given give VBN cord-005453-4057qib7 16490 9 . . . cord-005453-4057qib7 16491 1 Results result NNS cord-005453-4057qib7 16491 2 : : : cord-005453-4057qib7 16492 1 After after IN cord-005453-4057qib7 16492 2 setting set VBG cord-005453-4057qib7 16492 3 up up RP cord-005453-4057qib7 16492 4 structures structure NNS cord-005453-4057qib7 16492 5 for for IN cord-005453-4057qib7 16492 6 the the DT cord-005453-4057qib7 16492 7 counseling counseling NN cord-005453-4057qib7 16492 8 process process NN cord-005453-4057qib7 16492 9 we -PRON- PRP cord-005453-4057qib7 16492 10 counseled counsel VBD cord-005453-4057qib7 16492 11 140 140 CD cord-005453-4057qib7 16492 12 oncology oncology NN cord-005453-4057qib7 16492 13 and and CC cord-005453-4057qib7 16492 14 stem stem NN cord-005453-4057qib7 16492 15 cell cell NN cord-005453-4057qib7 16492 16 transplant transplant NN cord-005453-4057qib7 16492 17 patients patient NNS cord-005453-4057qib7 16492 18 ( ( -LRB- cord-005453-4057qib7 16492 19 0 0 CD cord-005453-4057qib7 16492 20 - - SYM cord-005453-4057qib7 16492 21 18 18 CD cord-005453-4057qib7 16492 22 years year NNS cord-005453-4057qib7 16492 23 ) ) -RRB- cord-005453-4057qib7 16492 24 between between IN cord-005453-4057qib7 16492 25 January January NNP cord-005453-4057qib7 16492 26 2017 2017 CD cord-005453-4057qib7 16492 27 and and CC cord-005453-4057qib7 16492 28 May May NNP cord-005453-4057qib7 16492 29 2018 2018 CD cord-005453-4057qib7 16492 30 . . . cord-005453-4057qib7 16493 1 We -PRON- PRP cord-005453-4057qib7 16493 2 analysed analyse VBD cord-005453-4057qib7 16493 3 data datum NNS cord-005453-4057qib7 16493 4 of of IN cord-005453-4057qib7 16493 5 the the DT cord-005453-4057qib7 16493 6 patients patient NNS cord-005453-4057qib7 16493 7 including include VBG cord-005453-4057qib7 16493 8 age age NN cord-005453-4057qib7 16493 9 subgroups subgroup NNS cord-005453-4057qib7 16493 10 and and CC cord-005453-4057qib7 16493 11 disease disease NN cord-005453-4057qib7 16493 12 entities entity NNS cord-005453-4057qib7 16493 13 and and CC cord-005453-4057qib7 16493 14 the the DT cord-005453-4057qib7 16493 15 results result NNS cord-005453-4057qib7 16493 16 of of IN cord-005453-4057qib7 16493 17 the the DT cord-005453-4057qib7 16493 18 counseling counseling NN cord-005453-4057qib7 16493 19 process process NN cord-005453-4057qib7 16493 20 . . . cord-005453-4057qib7 16494 1 For for IN cord-005453-4057qib7 16494 2 those those DT cord-005453-4057qib7 16494 3 patients patient NNS cord-005453-4057qib7 16494 4 undergoing undergo VBG cord-005453-4057qib7 16494 5 stem stem NN cord-005453-4057qib7 16494 6 cell cell NN cord-005453-4057qib7 16494 7 transplantation transplantation NN cord-005453-4057qib7 16494 8 the the DT cord-005453-4057qib7 16494 9 risk risk NN cord-005453-4057qib7 16494 10 of of IN cord-005453-4057qib7 16494 11 gonadotoxicity gonadotoxicity NN cord-005453-4057qib7 16494 12 is be VBZ cord-005453-4057qib7 16494 13 very very RB cord-005453-4057qib7 16494 14 high high JJ cord-005453-4057qib7 16494 15 , , , cord-005453-4057qib7 16494 16 therefore therefore RB cord-005453-4057qib7 16494 17 even even RB cord-005453-4057qib7 16494 18 the the DT cord-005453-4057qib7 16494 19 very very RB cord-005453-4057qib7 16494 20 young young JJ cord-005453-4057qib7 16494 21 children child NNS cord-005453-4057qib7 16494 22 underwent undergo VBD cord-005453-4057qib7 16494 23 fertility fertility NN cord-005453-4057qib7 16494 24 preserving preserve VBG cord-005453-4057qib7 16494 25 procedures procedure NNS cord-005453-4057qib7 16494 26 in in IN cord-005453-4057qib7 16494 27 alignment alignment NN cord-005453-4057qib7 16494 28 with with IN cord-005453-4057qib7 16494 29 our -PRON- PRP$ cord-005453-4057qib7 16494 30 recommendations recommendation NNS cord-005453-4057qib7 16494 31 if if IN cord-005453-4057qib7 16494 32 they -PRON- PRP cord-005453-4057qib7 16494 33 suffered suffer VBD cord-005453-4057qib7 16494 34 from from IN cord-005453-4057qib7 16494 35 a a DT cord-005453-4057qib7 16494 36 nonmalignant nonmalignant NNP cord-005453-4057qib7 16494 37 disease disease NN cord-005453-4057qib7 16494 38 . . . cord-005453-4057qib7 16495 1 Currently currently RB cord-005453-4057qib7 16495 2 we -PRON- PRP cord-005453-4057qib7 16495 3 discourage discourage VBP cord-005453-4057qib7 16495 4 tissue tissue NN cord-005453-4057qib7 16495 5 preserving preserve VBG cord-005453-4057qib7 16495 6 in in IN cord-005453-4057qib7 16495 7 malignant malignant JJ cord-005453-4057qib7 16495 8 systemic systemic JJ cord-005453-4057qib7 16495 9 disease disease NN cord-005453-4057qib7 16495 10 due due JJ cord-005453-4057qib7 16495 11 to to IN cord-005453-4057qib7 16495 12 possible possible JJ cord-005453-4057qib7 16495 13 contamination contamination NN cord-005453-4057qib7 16495 14 with with IN cord-005453-4057qib7 16495 15 malignant malignant JJ cord-005453-4057qib7 16495 16 cells cell NNS cord-005453-4057qib7 16495 17 . . . cord-005453-4057qib7 16496 1 Postpubertal postpubertal JJ cord-005453-4057qib7 16496 2 female female JJ cord-005453-4057qib7 16496 3 patients patient NNS cord-005453-4057qib7 16496 4 were be VBD cord-005453-4057qib7 16496 5 more more RBR cord-005453-4057qib7 16496 6 likely likely JJ cord-005453-4057qib7 16496 7 to to TO cord-005453-4057qib7 16496 8 undergo undergo VB cord-005453-4057qib7 16496 9 invasive invasive JJ cord-005453-4057qib7 16496 10 procedures procedure NNS cord-005453-4057qib7 16496 11 such such JJ cord-005453-4057qib7 16496 12 as as IN cord-005453-4057qib7 16496 13 ovarian ovarian JJ cord-005453-4057qib7 16496 14 tissue tissue NN cord-005453-4057qib7 16496 15 cryopreservation cryopreservation NN cord-005453-4057qib7 16496 16 in in IN cord-005453-4057qib7 16496 17 the the DT cord-005453-4057qib7 16496 18 case case NN cord-005453-4057qib7 16496 19 of of IN cord-005453-4057qib7 16496 20 oncological oncological JJ cord-005453-4057qib7 16496 21 diseases disease NNS cord-005453-4057qib7 16496 22 , , , cord-005453-4057qib7 16496 23 while while IN cord-005453-4057qib7 16496 24 sperm sperm NN cord-005453-4057qib7 16496 25 cryopreservation cryopreservation NN cord-005453-4057qib7 16496 26 was be VBD cord-005453-4057qib7 16496 27 recommended recommend VBN cord-005453-4057qib7 16496 28 in in IN cord-005453-4057qib7 16496 29 all all DT cord-005453-4057qib7 16496 30 postpubertal postpubertal JJ cord-005453-4057qib7 16496 31 male male JJ cord-005453-4057qib7 16496 32 patients patient NNS cord-005453-4057qib7 16496 33 . . . cord-005453-4057qib7 16497 1 Overall overall RB cord-005453-4057qib7 16497 2 a a DT cord-005453-4057qib7 16497 3 high high JJ cord-005453-4057qib7 16497 4 percentage percentage NN cord-005453-4057qib7 16497 5 of of IN cord-005453-4057qib7 16497 6 the the DT cord-005453-4057qib7 16497 7 patients patient NNS cord-005453-4057qib7 16497 8 and and CC cord-005453-4057qib7 16497 9 their -PRON- PRP$ cord-005453-4057qib7 16497 10 family family NN cord-005453-4057qib7 16497 11 followed follow VBD cord-005453-4057qib7 16497 12 our -PRON- PRP$ cord-005453-4057qib7 16497 13 recommendations recommendation NNS cord-005453-4057qib7 16497 14 . . . cord-005453-4057qib7 16498 1 Conclusions conclusion NNS cord-005453-4057qib7 16498 2 : : : cord-005453-4057qib7 16499 1 Fertility fertility NN cord-005453-4057qib7 16499 2 preservation preservation NN cord-005453-4057qib7 16499 3 should should MD cord-005453-4057qib7 16499 4 be be VB cord-005453-4057qib7 16499 5 considered consider VBN cord-005453-4057qib7 16499 6 as as IN cord-005453-4057qib7 16499 7 a a DT cord-005453-4057qib7 16499 8 very very RB cord-005453-4057qib7 16499 9 important important JJ cord-005453-4057qib7 16499 10 part part NN cord-005453-4057qib7 16499 11 of of IN cord-005453-4057qib7 16499 12 the the DT cord-005453-4057qib7 16499 13 treatment treatment NN cord-005453-4057qib7 16499 14 plan plan NN cord-005453-4057qib7 16499 15 for for IN cord-005453-4057qib7 16499 16 newly newly RB cord-005453-4057qib7 16499 17 diagnosed diagnose VBN cord-005453-4057qib7 16499 18 children child NNS cord-005453-4057qib7 16499 19 and and CC cord-005453-4057qib7 16499 20 young young JJ cord-005453-4057qib7 16499 21 adults adult NNS cord-005453-4057qib7 16499 22 with with IN cord-005453-4057qib7 16499 23 cancer cancer NN cord-005453-4057qib7 16499 24 and and CC cord-005453-4057qib7 16499 25 those those DT cord-005453-4057qib7 16499 26 facing face VBG cord-005453-4057qib7 16499 27 stem stem NN cord-005453-4057qib7 16499 28 cell cell NN cord-005453-4057qib7 16499 29 transplantation transplantation NN cord-005453-4057qib7 16499 30 . . . cord-005453-4057qib7 16500 1 Unfortunately unfortunately RB cord-005453-4057qib7 16500 2 there there EX cord-005453-4057qib7 16500 3 is be VBZ cord-005453-4057qib7 16500 4 still still RB cord-005453-4057qib7 16500 5 a a DT cord-005453-4057qib7 16500 6 great great JJ cord-005453-4057qib7 16500 7 need need NN cord-005453-4057qib7 16500 8 for for IN cord-005453-4057qib7 16500 9 setting set VBG cord-005453-4057qib7 16500 10 up up RP cord-005453-4057qib7 16500 11 structures structure NNS cord-005453-4057qib7 16500 12 in in IN cord-005453-4057qib7 16500 13 institutions institution NNS cord-005453-4057qib7 16500 14 taking take VBG cord-005453-4057qib7 16500 15 care care NN cord-005453-4057qib7 16500 16 of of IN cord-005453-4057qib7 16500 17 these these DT cord-005453-4057qib7 16500 18 patients patient NNS cord-005453-4057qib7 16500 19 . . . cord-005453-4057qib7 16501 1 In in IN cord-005453-4057qib7 16501 2 addition addition NN cord-005453-4057qib7 16501 3 fertility fertility NN cord-005453-4057qib7 16501 4 preservation preservation NN cord-005453-4057qib7 16501 5 sadly sadly RB cord-005453-4057qib7 16501 6 lacks lack VBZ cord-005453-4057qib7 16501 7 funding funding NN cord-005453-4057qib7 16501 8 by by IN cord-005453-4057qib7 16501 9 health health NN cord-005453-4057qib7 16501 10 insurance insurance NN cord-005453-4057qib7 16501 11 in in IN cord-005453-4057qib7 16501 12 some some DT cord-005453-4057qib7 16501 13 countries country NNS cord-005453-4057qib7 16501 14 . . . cord-005453-4057qib7 16502 1 With with IN cord-005453-4057qib7 16502 2 the the DT cord-005453-4057qib7 16502 3 presentation presentation NN cord-005453-4057qib7 16502 4 of of IN cord-005453-4057qib7 16502 5 our -PRON- PRP$ cord-005453-4057qib7 16502 6 experience experience NN cord-005453-4057qib7 16502 7 and and CC cord-005453-4057qib7 16502 8 data datum NNS cord-005453-4057qib7 16502 9 we -PRON- PRP cord-005453-4057qib7 16502 10 want want VBP cord-005453-4057qib7 16502 11 to to TO cord-005453-4057qib7 16502 12 facilitate facilitate VB cord-005453-4057qib7 16502 13 incorporation incorporation NN cord-005453-4057qib7 16502 14 of of IN cord-005453-4057qib7 16502 15 fertility fertility NN cord-005453-4057qib7 16502 16 counseling counsel VBG cord-005453-4057qib7 16502 17 in in IN cord-005453-4057qib7 16502 18 other other JJ cord-005453-4057qib7 16502 19 pediatric pediatric JJ cord-005453-4057qib7 16502 20 care care NN cord-005453-4057qib7 16502 21 centers center NNS cord-005453-4057qib7 16502 22 to to TO cord-005453-4057qib7 16502 23 provide provide VB cord-005453-4057qib7 16502 24 counseling counseling NN cord-005453-4057qib7 16502 25 for for IN cord-005453-4057qib7 16502 26 pediatric pediatric JJ cord-005453-4057qib7 16502 27 patients patient NNS cord-005453-4057qib7 16502 28 in in IN cord-005453-4057qib7 16502 29 need need NN cord-005453-4057qib7 16502 30 for for IN cord-005453-4057qib7 16502 31 fertility fertility NN cord-005453-4057qib7 16502 32 preservation preservation NN cord-005453-4057qib7 16502 33 . . . cord-005453-4057qib7 16503 1 Disclosure disclosure NN cord-005453-4057qib7 16503 2 : : : cord-005453-4057qib7 16503 3 no no DT cord-005453-4057qib7 16503 4 conflict conflict NN cord-005453-4057qib7 16503 5 of of IN cord-005453-4057qib7 16503 6 interest interest NN cord-005453-4057qib7 16503 7 Regulatory Regulatory NNP cord-005453-4057qib7 16503 8 T T NNP cord-005453-4057qib7 16503 9 - - HYPH cord-005453-4057qib7 16503 10 cells cell NNS cord-005453-4057qib7 16503 11 ( ( -LRB- cord-005453-4057qib7 16503 12 T T NNP cord-005453-4057qib7 16503 13 reg reg NNP cord-005453-4057qib7 16503 14 ) ) -RRB- cord-005453-4057qib7 16503 15 have have VBP cord-005453-4057qib7 16503 16 been be VBN cord-005453-4057qib7 16503 17 shown show VBN cord-005453-4057qib7 16503 18 to to TO cord-005453-4057qib7 16503 19 play play VB cord-005453-4057qib7 16503 20 a a DT cord-005453-4057qib7 16503 21 role role NN cord-005453-4057qib7 16503 22 not not RB cord-005453-4057qib7 16503 23 only only RB cord-005453-4057qib7 16503 24 in in IN cord-005453-4057qib7 16503 25 autoimmune autoimmune JJ cord-005453-4057qib7 16503 26 diseases disease NNS cord-005453-4057qib7 16503 27 and and CC cord-005453-4057qib7 16503 28 solid solid JJ cord-005453-4057qib7 16503 29 organ organ NN cord-005453-4057qib7 16503 30 transplantation transplantation NN cord-005453-4057qib7 16503 31 but but CC cord-005453-4057qib7 16503 32 also also RB cord-005453-4057qib7 16503 33 in in IN cord-005453-4057qib7 16503 34 GvHD GvHD NNP cord-005453-4057qib7 16503 35 . . . cord-005453-4057qib7 16504 1 Several several JJ cord-005453-4057qib7 16504 2 mouse mouse NN cord-005453-4057qib7 16504 3 models model NNS cord-005453-4057qib7 16504 4 showed show VBD cord-005453-4057qib7 16504 5 a a DT cord-005453-4057qib7 16504 6 decrease decrease NN cord-005453-4057qib7 16504 7 of of IN cord-005453-4057qib7 16504 8 GvHD gvhd NN cord-005453-4057qib7 16504 9 incidence incidence NN cord-005453-4057qib7 16504 10 after after IN cord-005453-4057qib7 16504 11 T T NNP cord-005453-4057qib7 16504 12 reg reg NNP cord-005453-4057qib7 16504 13 administration administration NN cord-005453-4057qib7 16504 14 . . . cord-005453-4057qib7 16505 1 The the DT cord-005453-4057qib7 16505 2 few few JJ cord-005453-4057qib7 16505 3 clinical clinical JJ cord-005453-4057qib7 16505 4 trials trial NNS cord-005453-4057qib7 16505 5 regarding regard VBG cord-005453-4057qib7 16505 6 the the DT cord-005453-4057qib7 16505 7 application application NN cord-005453-4057qib7 16505 8 of of IN cord-005453-4057qib7 16505 9 T T NNP cord-005453-4057qib7 16505 10 reg reg NNP cord-005453-4057qib7 16505 11 for for IN cord-005453-4057qib7 16505 12 the the DT cord-005453-4057qib7 16505 13 treatment treatment NN cord-005453-4057qib7 16505 14 of of IN cord-005453-4057qib7 16505 15 GvHD GvHD NNP cord-005453-4057qib7 16505 16 are be VBP cord-005453-4057qib7 16505 17 encouraging encouraging JJ cord-005453-4057qib7 16505 18 , , , cord-005453-4057qib7 16505 19 however however RB cord-005453-4057qib7 16505 20 the the DT cord-005453-4057qib7 16505 21 data data NN cord-005453-4057qib7 16505 22 is be VBZ cord-005453-4057qib7 16505 23 limited limited JJ cord-005453-4057qib7 16505 24 . . . cord-005453-4057qib7 16506 1 Methods method NNS cord-005453-4057qib7 16506 2 : : : cord-005453-4057qib7 16506 3 Patient patient NN cord-005453-4057qib7 16506 4 : : : cord-005453-4057qib7 16507 1 A a DT cord-005453-4057qib7 16507 2 14-year 14-year JJ cord-005453-4057qib7 16507 3 - - HYPH cord-005453-4057qib7 16507 4 old old JJ cord-005453-4057qib7 16507 5 boy boy NN cord-005453-4057qib7 16507 6 underwent undergo VBD cord-005453-4057qib7 16507 7 allogeneic allogeneic JJ cord-005453-4057qib7 16507 8 SCT SCT NNP cord-005453-4057qib7 16507 9 for for IN cord-005453-4057qib7 16507 10 chronic chronic JJ cord-005453-4057qib7 16507 11 myeloid myeloid NN cord-005453-4057qib7 16507 12 leukemia leukemia NN cord-005453-4057qib7 16507 13 refractory refractory JJ cord-005453-4057qib7 16507 14 to to IN cord-005453-4057qib7 16507 15 imatinib imatinib NN cord-005453-4057qib7 16507 16 , , , cord-005453-4057qib7 16507 17 dasatinib dasatinib NN cord-005453-4057qib7 16507 18 and and CC cord-005453-4057qib7 16507 19 nilotinib nilotinib JJ cord-005453-4057qib7 16507 20 treatment treatment NN cord-005453-4057qib7 16507 21 from from IN cord-005453-4057qib7 16507 22 his -PRON- PRP$ cord-005453-4057qib7 16507 23 10/10 10/10 CD cord-005453-4057qib7 16507 24 HLA HLA NNP cord-005453-4057qib7 16507 25 identical identical JJ cord-005453-4057qib7 16507 26 brother brother NN cord-005453-4057qib7 16507 27 . . . cord-005453-4057qib7 16508 1 Freshly freshly RB cord-005453-4057qib7 16508 2 derived derive VBN cord-005453-4057qib7 16508 3 unmanipulated unmanipulated JJ cord-005453-4057qib7 16508 4 bone bone NN cord-005453-4057qib7 16508 5 marrow marrow NN cord-005453-4057qib7 16508 6 was be VBD cord-005453-4057qib7 16508 7 transplanted transplant VBN cord-005453-4057qib7 16508 8 after after IN cord-005453-4057qib7 16508 9 conditioning condition VBG cord-005453-4057qib7 16508 10 with with IN cord-005453-4057qib7 16508 11 of of IN cord-005453-4057qib7 16508 12 fludarabine fludarabine NN cord-005453-4057qib7 16508 13 ( ( -LRB- cord-005453-4057qib7 16508 14 40 40 CD cord-005453-4057qib7 16508 15 mg mg NNP cord-005453-4057qib7 16508 16 / / SYM cord-005453-4057qib7 16508 17 m²/d m²/d NN cord-005453-4057qib7 16508 18 , , , cord-005453-4057qib7 16508 19 day day NN cord-005453-4057qib7 16508 20 -7 -7 ADD cord-005453-4057qib7 16508 21 to to IN cord-005453-4057qib7 16508 22 -4 -4 ADD cord-005453-4057qib7 16508 23 ) ) -RRB- cord-005453-4057qib7 16508 24 , , , cord-005453-4057qib7 16508 25 thiotepa thiotepa JJ cord-005453-4057qib7 16508 26 ( ( -LRB- cord-005453-4057qib7 16508 27 2x 2x CD cord-005453-4057qib7 16508 28 5mg/ 5mg/ CD cord-005453-4057qib7 16508 29 kg kg NN cord-005453-4057qib7 16508 30 , , , cord-005453-4057qib7 16508 31 day day NN cord-005453-4057qib7 16508 32 -3 -3 NNP cord-005453-4057qib7 16508 33 ) ) -RRB- cord-005453-4057qib7 16508 34 and and CC cord-005453-4057qib7 16508 35 melphalan melphalan NNP cord-005453-4057qib7 16508 36 ( ( -LRB- cord-005453-4057qib7 16508 37 160 160 CD cord-005453-4057qib7 16508 38 mg mg NNP cord-005453-4057qib7 16508 39 / / SYM cord-005453-4057qib7 16508 40 m² m² NNP cord-005453-4057qib7 16508 41 , , , cord-005453-4057qib7 16508 42 day day NN cord-005453-4057qib7 16508 43 -2 -2 CD cord-005453-4057qib7 16508 44 ) ) -RRB- cord-005453-4057qib7 16508 45 . . . cord-005453-4057qib7 16509 1 Cyclosporin Cyclosporin NNP cord-005453-4057qib7 16509 2 A a DT cord-005453-4057qib7 16509 3 ( ( -LRB- cord-005453-4057qib7 16509 4 CsA csa NN cord-005453-4057qib7 16509 5 ) ) -RRB- cord-005453-4057qib7 16509 6 and and CC cord-005453-4057qib7 16509 7 mycophenolatmofetil mycophenolatmofetil NNP cord-005453-4057qib7 16509 8 ( ( -LRB- cord-005453-4057qib7 16509 9 MMF MMF NNP cord-005453-4057qib7 16509 10 ) ) -RRB- cord-005453-4057qib7 16509 11 were be VBD cord-005453-4057qib7 16509 12 used use VBN cord-005453-4057qib7 16509 13 for for IN cord-005453-4057qib7 16509 14 GvHD GvHD NNP cord-005453-4057qib7 16509 15 prophylaxis prophylaxis NN cord-005453-4057qib7 16509 16 . . . cord-005453-4057qib7 16510 1 Leukocyte Leukocyte NNP cord-005453-4057qib7 16510 2 regeneration regeneration NN cord-005453-4057qib7 16510 3 ( ( -LRB- cord-005453-4057qib7 16510 4 > > NFP cord-005453-4057qib7 16510 5 1000 1000 CD cord-005453-4057qib7 16510 6 / / SYM cord-005453-4057qib7 16510 7 μl μl NN cord-005453-4057qib7 16510 8 ) ) -RRB- cord-005453-4057qib7 16510 9 was be VBD cord-005453-4057qib7 16510 10 seen see VBN cord-005453-4057qib7 16510 11 on on IN cord-005453-4057qib7 16510 12 day day NN cord-005453-4057qib7 16510 13 +15 +15 CD cord-005453-4057qib7 16511 1 , , , cord-005453-4057qib7 16511 2 granulocyte granulocyte NN cord-005453-4057qib7 16511 3 regeneration regeneration NN cord-005453-4057qib7 16511 4 ( ( -LRB- cord-005453-4057qib7 16511 5 > > NFP cord-005453-4057qib7 16511 6 500 500 CD cord-005453-4057qib7 16511 7 / / SYM cord-005453-4057qib7 16511 8 μl μl NN cord-005453-4057qib7 16511 9 ) ) -RRB- cord-005453-4057qib7 16511 10 on on IN cord-005453-4057qib7 16511 11 day day NN cord-005453-4057qib7 16511 12 +16 +16 NNP cord-005453-4057qib7 16511 13 and and CC cord-005453-4057qib7 16511 14 thrombocyte thrombocyte NN cord-005453-4057qib7 16511 15 regeneration regeneration NN cord-005453-4057qib7 16511 16 ( ( -LRB- cord-005453-4057qib7 16511 17 > > NFP cord-005453-4057qib7 16511 18 50.000 50.000 CD cord-005453-4057qib7 16511 19 / / SYM cord-005453-4057qib7 16511 20 μl μl NN cord-005453-4057qib7 16511 21 ) ) -RRB- cord-005453-4057qib7 16511 22 on on IN cord-005453-4057qib7 16511 23 day day NN cord-005453-4057qib7 16511 24 +21 +21 CD cord-005453-4057qib7 16511 25 . . . cord-005453-4057qib7 16512 1 On on IN cord-005453-4057qib7 16512 2 day day NN cord-005453-4057qib7 16512 3 +30 +30 CD cord-005453-4057qib7 16512 4 after after IN cord-005453-4057qib7 16512 5 SCT SCT NNP cord-005453-4057qib7 16512 6 he -PRON- PRP cord-005453-4057qib7 16512 7 developed develop VBD cord-005453-4057qib7 16512 8 acute acute JJ cord-005453-4057qib7 16512 9 intestinal intestinal JJ cord-005453-4057qib7 16512 10 GvHD GvHD NNP cord-005453-4057qib7 16512 11 that that WDT cord-005453-4057qib7 16512 12 exacerbated exacerbate VBD cord-005453-4057qib7 16512 13 to to IN cord-005453-4057qib7 16512 14 grade grade NN cord-005453-4057qib7 16512 15 IV IV NNP cord-005453-4057qib7 16512 16 ° ° NN cord-005453-4057qib7 16512 17 (bloody (bloody NN cord-005453-4057qib7 16512 18 diarrhea diarrhea NN cord-005453-4057qib7 16512 19 , , , cord-005453-4057qib7 16512 20 ileus ileus NNP cord-005453-4057qib7 16512 21 ) ) -RRB- cord-005453-4057qib7 16512 22 and and CC cord-005453-4057qib7 16512 23 did do VBD cord-005453-4057qib7 16512 24 neither neither CC cord-005453-4057qib7 16512 25 respond respond VB cord-005453-4057qib7 16512 26 to to IN cord-005453-4057qib7 16512 27 steroids steroid NNS cord-005453-4057qib7 16512 28 , , , cord-005453-4057qib7 16512 29 nor nor CC cord-005453-4057qib7 16512 30 to to IN cord-005453-4057qib7 16512 31 different different JJ cord-005453-4057qib7 16512 32 immunosuppressive immunosuppressive JJ cord-005453-4057qib7 16512 33 drugs drug NNS cord-005453-4057qib7 16512 34 such such JJ cord-005453-4057qib7 16512 35 as as IN cord-005453-4057qib7 16512 36 cyclosporin cyclosporin NN cord-005453-4057qib7 16512 37 , , , cord-005453-4057qib7 16512 38 tacrolimus tacrolimus NNP cord-005453-4057qib7 16512 39 , , , cord-005453-4057qib7 16512 40 sirolimus sirolimus NNP cord-005453-4057qib7 16512 41 , , , cord-005453-4057qib7 16512 42 mycophenolatemofetil mycophenolatemofetil NNP cord-005453-4057qib7 16512 43 and and CC cord-005453-4057qib7 16512 44 ruxolitinib ruxolitinib NNP cord-005453-4057qib7 16512 45 . . . cord-005453-4057qib7 16513 1 Extracorporal Extracorporal NNP cord-005453-4057qib7 16513 2 photopheresis photopheresis NNP cord-005453-4057qib7 16513 3 and and CC cord-005453-4057qib7 16513 4 the the DT cord-005453-4057qib7 16513 5 administration administration NN cord-005453-4057qib7 16513 6 of of IN cord-005453-4057qib7 16513 7 immunmodulatory immunmodulatory NNP cord-005453-4057qib7 16513 8 antibodies antibodies NNP cord-005453-4057qib7 16513 9 ( ( -LRB- cord-005453-4057qib7 16513 10 adalimumab adalimumab NNP cord-005453-4057qib7 16513 11 and and CC cord-005453-4057qib7 16513 12 tocilizumab tocilizumab NNP cord-005453-4057qib7 16513 13 ) ) -RRB- cord-005453-4057qib7 16513 14 did do VBD cord-005453-4057qib7 16513 15 not not RB cord-005453-4057qib7 16513 16 succeed succeed VB cord-005453-4057qib7 16513 17 either either RB cord-005453-4057qib7 16513 18 . . . cord-005453-4057qib7 16514 1 Results result NNS cord-005453-4057qib7 16514 2 : : : cord-005453-4057qib7 16515 1 By by IN cord-005453-4057qib7 16515 2 administration administration NN cord-005453-4057qib7 16515 3 of of IN cord-005453-4057qib7 16515 4 low low JJ cord-005453-4057qib7 16515 5 - - HYPH cord-005453-4057qib7 16515 6 dose dose NN cord-005453-4057qib7 16515 7 interleukin-2 interleukin-2 IN cord-005453-4057qib7 16515 8 ( ( -LRB- cord-005453-4057qib7 16515 9 IL-2 IL-2 NNP cord-005453-4057qib7 16515 10 ) ) -RRB- cord-005453-4057qib7 16515 11 in in IN cord-005453-4057qib7 16515 12 vivo vivo NN cord-005453-4057qib7 16515 13 induction induction NN cord-005453-4057qib7 16515 14 of of IN cord-005453-4057qib7 16515 15 T T NNP cord-005453-4057qib7 16515 16 reg reg NNP cord-005453-4057qib7 16515 17 was be VBD cord-005453-4057qib7 16515 18 expected expect VBN cord-005453-4057qib7 16515 19 but but CC cord-005453-4057qib7 16515 20 did do VBD cord-005453-4057qib7 16515 21 not not RB cord-005453-4057qib7 16515 22 succeed succeed VB cord-005453-4057qib7 16515 23 . . . cord-005453-4057qib7 16516 1 Finally finally RB cord-005453-4057qib7 16516 2 antithymocyte antithymocyte NNP cord-005453-4057qib7 16516 3 globuline globuline NNP cord-005453-4057qib7 16516 4 ( ( -LRB- cord-005453-4057qib7 16516 5 ATG ATG NNP cord-005453-4057qib7 16516 6 , , , cord-005453-4057qib7 16516 7 20 20 CD cord-005453-4057qib7 16516 8 mg mg NNP cord-005453-4057qib7 16516 9 / / SYM cord-005453-4057qib7 16516 10 kg/ kg/ NNP cord-005453-4057qib7 16516 11 d d NNP cord-005453-4057qib7 16516 12 ) ) -RRB- cord-005453-4057qib7 16516 13 was be VBD cord-005453-4057qib7 16516 14 administered administer VBN cord-005453-4057qib7 16516 15 on on IN cord-005453-4057qib7 16516 16 day day NN cord-005453-4057qib7 16516 17 +150 +150 NNP cord-005453-4057qib7 16516 18 to to IN cord-005453-4057qib7 16516 19 +152 +152 NNP cord-005453-4057qib7 16516 20 to to TO cord-005453-4057qib7 16516 21 eliminate eliminate VB cord-005453-4057qib7 16516 22 the the DT cord-005453-4057qib7 16516 23 GvHD gvhd NN cord-005453-4057qib7 16516 24 - - HYPH cord-005453-4057qib7 16516 25 triggering trigger VBG cord-005453-4057qib7 16516 26 cells cell NNS cord-005453-4057qib7 16516 27 . . . cord-005453-4057qib7 16517 1 Hence hence RB cord-005453-4057qib7 16517 2 , , , cord-005453-4057qib7 16517 3 the the DT cord-005453-4057qib7 16517 4 GvHD gvhd NN cord-005453-4057qib7 16517 5 declined decline VBD cord-005453-4057qib7 16517 6 to to IN cord-005453-4057qib7 16517 7 grade grade NN cord-005453-4057qib7 16517 8 III III NNP cord-005453-4057qib7 16517 9 . . . cord-005453-4057qib7 16518 1 Finally finally RB cord-005453-4057qib7 16518 2 , , , cord-005453-4057qib7 16518 3 a a DT cord-005453-4057qib7 16518 4 decision decision NN cord-005453-4057qib7 16518 5 was be VBD cord-005453-4057qib7 16518 6 made make VBN cord-005453-4057qib7 16518 7 to to TO cord-005453-4057qib7 16518 8 manufacture manufacture VB cord-005453-4057qib7 16518 9 T T NNP cord-005453-4057qib7 16518 10 reg reg NN cord-005453-4057qib7 16518 11 from from IN cord-005453-4057qib7 16518 12 his -PRON- PRP$ cord-005453-4057qib7 16518 13 stem stem NN cord-005453-4057qib7 16518 14 cell cell NN cord-005453-4057qib7 16518 15 donor donor NN cord-005453-4057qib7 16518 16 . . . cord-005453-4057qib7 16519 1 From from IN cord-005453-4057qib7 16519 2 an an DT cord-005453-4057qib7 16519 3 unstimulated unstimulated JJ cord-005453-4057qib7 16519 4 leukapheresis leukapheresis NN cord-005453-4057qib7 16519 5 T T NNP cord-005453-4057qib7 16519 6 reg reg NNP cord-005453-4057qib7 16519 7 were be VBD cord-005453-4057qib7 16519 8 selected select VBN cord-005453-4057qib7 16519 9 by by IN cord-005453-4057qib7 16519 10 magnetic magnetic JJ cord-005453-4057qib7 16519 11 depletion depletion NN cord-005453-4057qib7 16519 12 of of IN cord-005453-4057qib7 16519 13 CD8 CD8 NNP cord-005453-4057qib7 16519 14 + + CC cord-005453-4057qib7 16519 15 T T NNP cord-005453-4057qib7 16519 16 - - HYPH cord-005453-4057qib7 16519 17 cells cell NNS cord-005453-4057qib7 16519 18 and and CC cord-005453-4057qib7 16519 19 CD19 CD19 NNP cord-005453-4057qib7 16519 20 + + CC cord-005453-4057qib7 16519 21 B b NN cord-005453-4057qib7 16519 22 - - HYPH cord-005453-4057qib7 16519 23 cells cell NNS cord-005453-4057qib7 16519 24 followed follow VBN cord-005453-4057qib7 16519 25 by by IN cord-005453-4057qib7 16519 26 positive positive JJ cord-005453-4057qib7 16519 27 selection selection NN cord-005453-4057qib7 16519 28 of of IN cord-005453-4057qib7 16519 29 CD25 CD25 NNP cord-005453-4057qib7 16519 30 + + CC cord-005453-4057qib7 16519 31 Background background NN cord-005453-4057qib7 16519 32 : : : cord-005453-4057qib7 16520 1 Treatment treatment NN cord-005453-4057qib7 16520 2 of of IN cord-005453-4057qib7 16520 3 patients patient NNS cord-005453-4057qib7 16520 4 with with IN cord-005453-4057qib7 16520 5 transfusion transfusion NN cord-005453-4057qib7 16520 6 dependent dependent JJ cord-005453-4057qib7 16520 7 anemia anemia NN cord-005453-4057qib7 16520 8 like like IN cord-005453-4057qib7 16520 9 thalassemia thalassemia NN cord-005453-4057qib7 16520 10 major major NN cord-005453-4057qib7 16520 11 ( ( -LRB- cord-005453-4057qib7 16520 12 TM TM NNP cord-005453-4057qib7 16520 13 ) ) -RRB- cord-005453-4057qib7 16520 14 , , , cord-005453-4057qib7 16520 15 sickle sickle NN cord-005453-4057qib7 16520 16 cell cell NN cord-005453-4057qib7 16520 17 disease disease NN cord-005453-4057qib7 16520 18 ( ( -LRB- cord-005453-4057qib7 16520 19 SCD SCD NNP cord-005453-4057qib7 16520 20 ) ) -RRB- cord-005453-4057qib7 16520 21 and and CC cord-005453-4057qib7 16520 22 Diamond Diamond NNP cord-005453-4057qib7 16520 23 - - HYPH cord-005453-4057qib7 16520 24 Blackfan Blackfan NNP cord-005453-4057qib7 16520 25 anemia anemia NN cord-005453-4057qib7 16520 26 ( ( -LRB- cord-005453-4057qib7 16520 27 DBA DBA NNP cord-005453-4057qib7 16520 28 ) ) -RRB- cord-005453-4057qib7 16520 29 has have VBZ cord-005453-4057qib7 16520 30 improved improve VBN cord-005453-4057qib7 16520 31 over over IN cord-005453-4057qib7 16520 32 the the DT cord-005453-4057qib7 16520 33 last last JJ cord-005453-4057qib7 16520 34 decades decade NNS cord-005453-4057qib7 16520 35 . . . cord-005453-4057qib7 16521 1 For for IN cord-005453-4057qib7 16521 2 the the DT cord-005453-4057qib7 16521 3 vast vast JJ cord-005453-4057qib7 16521 4 majority majority NN cord-005453-4057qib7 16521 5 of of IN cord-005453-4057qib7 16521 6 patients patient NNS cord-005453-4057qib7 16521 7 , , , cord-005453-4057qib7 16521 8 allogeneic allogeneic IN cord-005453-4057qib7 16521 9 hematopoietic hematopoietic JJ cord-005453-4057qib7 16521 10 stem stem NN cord-005453-4057qib7 16521 11 cell cell NN cord-005453-4057qib7 16521 12 transplantation transplantation NN cord-005453-4057qib7 16521 13 ( ( -LRB- cord-005453-4057qib7 16521 14 HSCT HSCT NNP cord-005453-4057qib7 16521 15 ) ) -RRB- cord-005453-4057qib7 16521 16 is be VBZ cord-005453-4057qib7 16521 17 the the DT cord-005453-4057qib7 16521 18 only only RB cord-005453-4057qib7 16521 19 available available JJ cord-005453-4057qib7 16521 20 curative curative JJ cord-005453-4057qib7 16521 21 therapy therapy NN cord-005453-4057qib7 16521 22 . . . cord-005453-4057qib7 16522 1 For for IN cord-005453-4057qib7 16522 2 a a DT cord-005453-4057qib7 16522 3 long long JJ cord-005453-4057qib7 16522 4 time time NN cord-005453-4057qib7 16522 5 , , , cord-005453-4057qib7 16522 6 HSCT HSCT NNP cord-005453-4057qib7 16522 7 has have VBZ cord-005453-4057qib7 16522 8 only only RB cord-005453-4057qib7 16522 9 been be VBN cord-005453-4057qib7 16522 10 performed perform VBN cord-005453-4057qib7 16522 11 from from IN cord-005453-4057qib7 16522 12 HLA HLA NNP cord-005453-4057qib7 16522 13 - - HYPH cord-005453-4057qib7 16522 14 identical identical JJ cord-005453-4057qib7 16522 15 sibling sibling NN cord-005453-4057qib7 16522 16 donors donor NNS cord-005453-4057qib7 16522 17 ( ( -LRB- cord-005453-4057qib7 16522 18 MSD MSD NNP cord-005453-4057qib7 16522 19 ) ) -RRB- cord-005453-4057qib7 16522 20 or or CC cord-005453-4057qib7 16522 21 matched match VBN cord-005453-4057qib7 16522 22 family family NN cord-005453-4057qib7 16522 23 donors donor NNS cord-005453-4057qib7 16522 24 ( ( -LRB- cord-005453-4057qib7 16522 25 MFD MFD NNP cord-005453-4057qib7 16522 26 ) ) -RRB- cord-005453-4057qib7 16522 27 . . . cord-005453-4057qib7 16523 1 However however RB cord-005453-4057qib7 16523 2 , , , cord-005453-4057qib7 16523 3 approximately approximately RB cord-005453-4057qib7 16523 4 only only RB cord-005453-4057qib7 16523 5 25 25 CD cord-005453-4057qib7 16523 6 - - SYM cord-005453-4057qib7 16523 7 30 30 CD cord-005453-4057qib7 16523 8 % % NN cord-005453-4057qib7 16523 9 of of IN cord-005453-4057qib7 16523 10 affected affected JJ cord-005453-4057qib7 16523 11 patients patient NNS cord-005453-4057qib7 16523 12 do do VBP cord-005453-4057qib7 16523 13 have have VB cord-005453-4057qib7 16523 14 a a DT cord-005453-4057qib7 16523 15 matched match VBN cord-005453-4057qib7 16523 16 sibling sibling NN cord-005453-4057qib7 16523 17 donor donor NN cord-005453-4057qib7 16523 18 , , , cord-005453-4057qib7 16523 19 therefore therefore RB cord-005453-4057qib7 16523 20 HSCT HSCT NNP cord-005453-4057qib7 16523 21 from from IN cord-005453-4057qib7 16523 22 10/ 10/ CD cord-005453-4057qib7 16523 23 10 10 CD cord-005453-4057qib7 16523 24 ( ( -LRB- cord-005453-4057qib7 16523 25 MUD mud NN cord-005453-4057qib7 16523 26 ) ) -RRB- cord-005453-4057qib7 16523 27 and and CC cord-005453-4057qib7 16523 28 even even RB cord-005453-4057qib7 16523 29 9/10 9/10 CD cord-005453-4057qib7 16523 30 ( ( -LRB- cord-005453-4057qib7 16523 31 MMUD MMUD NNP cord-005453-4057qib7 16523 32 ) ) -RRB- cord-005453-4057qib7 16524 1 matched match VBN cord-005453-4057qib7 16524 2 unrelated unrelated JJ cord-005453-4057qib7 16524 3 donors donor NNS cord-005453-4057qib7 16524 4 has have VBZ cord-005453-4057qib7 16524 5 gained gain VBN cord-005453-4057qib7 16524 6 importance importance NN cord-005453-4057qib7 16524 7 in in IN cord-005453-4057qib7 16524 8 recent recent JJ cord-005453-4057qib7 16524 9 years year NNS cord-005453-4057qib7 16524 10 . . . cord-005453-4057qib7 16525 1 Methods method NNS cord-005453-4057qib7 16525 2 : : : cord-005453-4057qib7 16525 3 36 36 CD cord-005453-4057qib7 16525 4 patients patient NNS cord-005453-4057qib7 16525 5 ( ( -LRB- cord-005453-4057qib7 16525 6 age age NN cord-005453-4057qib7 16525 7 range range NN cord-005453-4057qib7 16525 8 : : : cord-005453-4057qib7 16525 9 2 2 CD cord-005453-4057qib7 16525 10 - - SYM cord-005453-4057qib7 16525 11 27 27 CD cord-005453-4057qib7 16525 12 years year NNS cord-005453-4057qib7 16525 13 ) ) -RRB- cord-005453-4057qib7 16525 14 with with IN cord-005453-4057qib7 16525 15 SCD SCD NNP cord-005453-4057qib7 16525 16 ( ( -LRB- cord-005453-4057qib7 16525 17 n=7 n=7 NNP cord-005453-4057qib7 16525 18 ) ) -RRB- cord-005453-4057qib7 16525 19 , , , cord-005453-4057qib7 16525 20 DBA DBA NNP cord-005453-4057qib7 16525 21 ( ( -LRB- cord-005453-4057qib7 16525 22 n=6 n=6 NNP cord-005453-4057qib7 16525 23 ) ) -RRB- cord-005453-4057qib7 16525 24 or or CC cord-005453-4057qib7 16525 25 TM TM NNP cord-005453-4057qib7 16525 26 ( ( -LRB- cord-005453-4057qib7 16525 27 n=23 n=23 NNP cord-005453-4057qib7 16525 28 ) ) -RRB- cord-005453-4057qib7 16525 29 , , , cord-005453-4057qib7 16525 30 receiving receive VBG cord-005453-4057qib7 16525 31 HSCT HSCT NNP cord-005453-4057qib7 16525 32 from from IN cord-005453-4057qib7 16525 33 a a DT cord-005453-4057qib7 16525 34 MSD MSD NNP cord-005453-4057qib7 16525 35 , , , cord-005453-4057qib7 16525 36 MFD MFD NNP cord-005453-4057qib7 16525 37 , , , cord-005453-4057qib7 16525 38 MUD MUD NNP cord-005453-4057qib7 16525 39 or or CC cord-005453-4057qib7 16525 40 MMUD MMUD NNP cord-005453-4057qib7 16525 41 between between IN cord-005453-4057qib7 16525 42 2010 2010 CD cord-005453-4057qib7 16525 43 and and CC cord-005453-4057qib7 16525 44 2019 2019 CD cord-005453-4057qib7 16525 45 were be VBD cord-005453-4057qib7 16525 46 included include VBN cord-005453-4057qib7 16525 47 in in IN cord-005453-4057qib7 16525 48 our -PRON- PRP$ cord-005453-4057qib7 16525 49 analysis analysis NN cord-005453-4057qib7 16525 50 . . . cord-005453-4057qib7 16526 1 23 23 CD cord-005453-4057qib7 16526 2 patients patient NNS cord-005453-4057qib7 16526 3 received receive VBD cord-005453-4057qib7 16526 4 transplants transplant NNS cord-005453-4057qib7 16526 5 from from IN cord-005453-4057qib7 16526 6 MSD MSD NNP cord-005453-4057qib7 16526 7 / / SYM cord-005453-4057qib7 16526 8 MFD MFD NNP cord-005453-4057qib7 16526 9 , , , cord-005453-4057qib7 16526 10 13 13 CD cord-005453-4057qib7 16526 11 patients patient NNS cord-005453-4057qib7 16526 12 from from IN cord-005453-4057qib7 16526 13 MUD/ MUD/ NNP cord-005453-4057qib7 16526 14 MMUD MMUD NNP cord-005453-4057qib7 16526 15 . . . cord-005453-4057qib7 16527 1 7 7 CD cord-005453-4057qib7 16527 2 patients patient NNS cord-005453-4057qib7 16527 3 were be VBD cord-005453-4057qib7 16527 4 identical identical JJ cord-005453-4057qib7 16527 5 for for IN cord-005453-4057qib7 16527 6 HLA HLA NNP cord-005453-4057qib7 16527 7 - - HYPH cord-005453-4057qib7 16527 8 A A NNP cord-005453-4057qib7 16527 9 , , , cord-005453-4057qib7 16527 10 B B NNP cord-005453-4057qib7 16527 11 , , , cord-005453-4057qib7 16527 12 CW CW NNP cord-005453-4057qib7 16527 13 , , , cord-005453-4057qib7 16527 14 DRB1 DRB1 NNP cord-005453-4057qib7 16527 15 and and CC cord-005453-4057qib7 16527 16 DQB1 DQB1 NNP cord-005453-4057qib7 16527 17 , , , cord-005453-4057qib7 16527 18 6 6 CD cord-005453-4057qib7 16527 19 patients patient NNS cord-005453-4057qib7 16527 20 shared share VBD cord-005453-4057qib7 16527 21 only only RB cord-005453-4057qib7 16527 22 9/10 9/10 CD cord-005453-4057qib7 16527 23 genes gene NNS cord-005453-4057qib7 16527 24 . . . cord-005453-4057qib7 16528 1 We -PRON- PRP cord-005453-4057qib7 16528 2 analyzed analyze VBD cord-005453-4057qib7 16528 3 extended extended JJ cord-005453-4057qib7 16528 4 haplotypes haplotype NNS cord-005453-4057qib7 16528 5 including include VBG cord-005453-4057qib7 16528 6 DRB3 DRB3 NNP cord-005453-4057qib7 16528 7 , , , cord-005453-4057qib7 16528 8 DRB4 DRB4 NNP cord-005453-4057qib7 16528 9 , , , cord-005453-4057qib7 16528 10 DRB5 DRB5 NNP cord-005453-4057qib7 16528 11 and and CC cord-005453-4057qib7 16528 12 DPB1 DPB1 NNP cord-005453-4057qib7 16528 13 for for IN cord-005453-4057qib7 16528 14 all all DT cord-005453-4057qib7 16528 15 patients patient NNS cord-005453-4057qib7 16528 16 with with IN cord-005453-4057qib7 16528 17 thalassemia thalassemia NN cord-005453-4057qib7 16528 18 . . . cord-005453-4057qib7 16529 1 7 7 CD cord-005453-4057qib7 16529 2 pairs pair NNS cord-005453-4057qib7 16529 3 showed show VBD cord-005453-4057qib7 16529 4 non non JJ cord-005453-4057qib7 16529 5 - - JJ cord-005453-4057qib7 16529 6 permissive permissive JJ cord-005453-4057qib7 16529 7 DPB1 dpb1 JJ cord-005453-4057qib7 16529 8 mismatch mismatch NN cord-005453-4057qib7 16529 9 and and CC cord-005453-4057qib7 16529 10 1 1 CD cord-005453-4057qib7 16529 11 pair pair NN cord-005453-4057qib7 16529 12 mismatch mismatch NN cord-005453-4057qib7 16529 13 for for IN cord-005453-4057qib7 16529 14 DPB1 DPB1 NNP cord-005453-4057qib7 16529 15 and and CC cord-005453-4057qib7 16529 16 DRB4.Results DRB4.Results NNP cord-005453-4057qib7 16529 17 : : : cord-005453-4057qib7 16529 18 Median median JJ cord-005453-4057qib7 16529 19 time time NN cord-005453-4057qib7 16529 20 for for IN cord-005453-4057qib7 16529 21 granulocyte granulocyte NN cord-005453-4057qib7 16529 22 recovery recovery NN cord-005453-4057qib7 16529 23 was be VBD cord-005453-4057qib7 16529 24 20 20 CD cord-005453-4057qib7 16529 25 days day NNS cord-005453-4057qib7 16529 26 in in IN cord-005453-4057qib7 16529 27 patients patient NNS cord-005453-4057qib7 16529 28 transplanted transplant VBN cord-005453-4057qib7 16529 29 from from IN cord-005453-4057qib7 16529 30 MSD MSD NNP cord-005453-4057qib7 16529 31 / / SYM cord-005453-4057qib7 16529 32 MFD MFD NNP cord-005453-4057qib7 16529 33 and and CC cord-005453-4057qib7 16529 34 22 22 CD cord-005453-4057qib7 16529 35 days day NNS cord-005453-4057qib7 16529 36 in in IN cord-005453-4057qib7 16529 37 patients patient NNS cord-005453-4057qib7 16529 38 transplanted transplant VBN cord-005453-4057qib7 16529 39 from from IN cord-005453-4057qib7 16529 40 MUD mud NN cord-005453-4057qib7 16529 41 / / SYM cord-005453-4057qib7 16529 42 MMUD MMUD NNP cord-005453-4057qib7 16529 43 . . . cord-005453-4057qib7 16530 1 Platelet platelet NN cord-005453-4057qib7 16530 2 recovery recovery NN cord-005453-4057qib7 16530 3 was be VBD cord-005453-4057qib7 16530 4 reached reach VBN cord-005453-4057qib7 16530 5 after after IN cord-005453-4057qib7 16530 6 22 22 CD cord-005453-4057qib7 16530 7 days day NNS cord-005453-4057qib7 16530 8 after after IN cord-005453-4057qib7 16530 9 HSCT HSCT NNP cord-005453-4057qib7 16530 10 from from IN cord-005453-4057qib7 16530 11 MSD MSD NNP cord-005453-4057qib7 16530 12 / / SYM cord-005453-4057qib7 16530 13 MFD MFD NNP cord-005453-4057qib7 16530 14 and and CC cord-005453-4057qib7 16530 15 24 24 CD cord-005453-4057qib7 16530 16 days day NNS cord-005453-4057qib7 16530 17 after after IN cord-005453-4057qib7 16530 18 HSCT HSCT NNP cord-005453-4057qib7 16530 19 from from IN cord-005453-4057qib7 16530 20 MUD/ MUD/ NNP cord-005453-4057qib7 16530 21 MMUD MMUD NNP cord-005453-4057qib7 16530 22 . . . cord-005453-4057qib7 16531 1 28/36 28/36 CD cord-005453-4057qib7 16531 2 ( ( -LRB- cord-005453-4057qib7 16531 3 80 80 CD cord-005453-4057qib7 16531 4 % % NN cord-005453-4057qib7 16531 5 ) ) -RRB- cord-005453-4057qib7 16531 6 patients patient NNS cord-005453-4057qib7 16531 7 showed show VBD cord-005453-4057qib7 16531 8 complete complete JJ cord-005453-4057qib7 16531 9 donor donor NN cord-005453-4057qib7 16531 10 chimerism chimerism NN cord-005453-4057qib7 16531 11 in in IN cord-005453-4057qib7 16531 12 all all DT cord-005453-4057qib7 16531 13 controls control NNS cord-005453-4057qib7 16531 14 . . . cord-005453-4057qib7 16532 1 5/36 5/36 CD cord-005453-4057qib7 16532 2 ( ( -LRB- cord-005453-4057qib7 16532 3 13 13 CD cord-005453-4057qib7 16532 4 % % NN cord-005453-4057qib7 16532 5 ) ) -RRB- cord-005453-4057qib7 16532 6 patients patient NNS cord-005453-4057qib7 16532 7 showed show VBD cord-005453-4057qib7 16532 8 low low JJ cord-005453-4057qib7 16532 9 level level NN cord-005453-4057qib7 16532 10 mixed mix VBN cord-005453-4057qib7 16532 11 chimerism chimerism NN cord-005453-4057qib7 16532 12 up up IN cord-005453-4057qib7 16532 13 to to TO cord-005453-4057qib7 16532 14 20 20 CD cord-005453-4057qib7 16532 15 % % NN cord-005453-4057qib7 16532 16 during during IN cord-005453-4057qib7 16532 17 follow follow NN cord-005453-4057qib7 16532 18 up up RP cord-005453-4057qib7 16532 19 . . . cord-005453-4057qib7 16533 1 1 1 CD cord-005453-4057qib7 16533 2 patient patient NN cord-005453-4057qib7 16533 3 died die VBD cord-005453-4057qib7 16533 4 shortly shortly RB cord-005453-4057qib7 16533 5 after after IN cord-005453-4057qib7 16533 6 HSCT HSCT NNP cord-005453-4057qib7 16533 7 , , , cord-005453-4057qib7 16533 8 1 1 CD cord-005453-4057qib7 16533 9 patient patient NN cord-005453-4057qib7 16533 10 showed show VBD cord-005453-4057qib7 16533 11 slowly slowly RB cord-005453-4057qib7 16533 12 increasing increase VBG cord-005453-4057qib7 16533 13 mixed mixed JJ cord-005453-4057qib7 16533 14 chimerism chimerism NN cord-005453-4057qib7 16533 15 and and CC cord-005453-4057qib7 16533 16 finally finally RB cord-005453-4057qib7 16533 17 developed develop VBD cord-005453-4057qib7 16533 18 autologous autologous JJ cord-005453-4057qib7 16533 19 recovery recovery NN cord-005453-4057qib7 16533 20 and and CC cord-005453-4057qib7 16533 21 one one CD cord-005453-4057qib7 16533 22 patient patient NN cord-005453-4057qib7 16533 23 rejected reject VBD cord-005453-4057qib7 16533 24 the the DT cord-005453-4057qib7 16533 25 graft graft NN cord-005453-4057qib7 16533 26 . . . cord-005453-4057qib7 16534 1 Cumulative cumulative JJ cord-005453-4057qib7 16534 2 incidence incidence NN cord-005453-4057qib7 16534 3 of of IN cord-005453-4057qib7 16534 4 grade grade NN cord-005453-4057qib7 16534 5 II II NNP cord-005453-4057qib7 16534 6 - - HYPH cord-005453-4057qib7 16534 7 IV IV NNP cord-005453-4057qib7 16534 8 acute acute JJ cord-005453-4057qib7 16534 9 graft graft NN cord-005453-4057qib7 16534 10 - - HYPH cord-005453-4057qib7 16534 11 versushost versushost NN cord-005453-4057qib7 16534 12 disease disease NN cord-005453-4057qib7 16534 13 ( ( -LRB- cord-005453-4057qib7 16534 14 aGVHD aGVHD NNP cord-005453-4057qib7 16534 15 ) ) -RRB- cord-005453-4057qib7 16534 16 of of IN cord-005453-4057qib7 16534 17 MUD MUD NNP cord-005453-4057qib7 16534 18 / / SYM cord-005453-4057qib7 16534 19 MMUD MMUD NNP cord-005453-4057qib7 16534 20 was be VBD cord-005453-4057qib7 16534 21 15,2 15,2 CD cord-005453-4057qib7 16534 22 % % NN cord-005453-4057qib7 16534 23 , , , cord-005453-4057qib7 16534 24 whereas whereas IN cord-005453-4057qib7 16534 25 only only RB cord-005453-4057qib7 16534 26 2 2 CD cord-005453-4057qib7 16534 27 cases case NNS cord-005453-4057qib7 16534 28 of of IN cord-005453-4057qib7 16534 29 aGVHD aGVHD NNP cord-005453-4057qib7 16534 30 grade grade NN cord-005453-4057qib7 16534 31 I -PRON- PRP cord-005453-4057qib7 16534 32 occurred occur VBD cord-005453-4057qib7 16534 33 in in IN cord-005453-4057qib7 16534 34 patients patient NNS cord-005453-4057qib7 16534 35 transplanted transplant VBN cord-005453-4057qib7 16534 36 from from IN cord-005453-4057qib7 16534 37 MSD MSD NNP cord-005453-4057qib7 16534 38 / / SYM cord-005453-4057qib7 16534 39 MFD MFD NNP cord-005453-4057qib7 16534 40 . . . cord-005453-4057qib7 16535 1 As as IN cord-005453-4057qib7 16535 2 1 1 CD cord-005453-4057qib7 16535 3 patient patient NN cord-005453-4057qib7 16535 4 rejected reject VBD cord-005453-4057qib7 16535 5 the the DT cord-005453-4057qib7 16535 6 graft graft NN cord-005453-4057qib7 16535 7 from from IN cord-005453-4057qib7 16535 8 a a DT cord-005453-4057qib7 16535 9 HLA HLA NNP cord-005453-4057qib7 16535 10 - - HYPH cord-005453-4057qib7 16535 11 identical identical JJ cord-005453-4057qib7 16535 12 parent parent NN cord-005453-4057qib7 16535 13 , , , cord-005453-4057qib7 16535 14 1 1 CD cord-005453-4057qib7 16535 15 patient patient NN cord-005453-4057qib7 16535 16 transplanted transplant VBN cord-005453-4057qib7 16535 17 from from IN cord-005453-4057qib7 16535 18 a a DT cord-005453-4057qib7 16535 19 HLA HLA NNP cord-005453-4057qib7 16535 20 - - HYPH cord-005453-4057qib7 16535 21 identical identical JJ cord-005453-4057qib7 16535 22 grandparent grandparent NN cord-005453-4057qib7 16535 23 developed develop VBD cord-005453-4057qib7 16535 24 autologous autologous JJ cord-005453-4057qib7 16535 25 recovery recovery NN cord-005453-4057qib7 16535 26 after after IN cord-005453-4057qib7 16535 27 1 1 CD cord-005453-4057qib7 16535 28 year year NN cord-005453-4057qib7 16535 29 and and CC cord-005453-4057qib7 16535 30 1 1 CD cord-005453-4057qib7 16535 31 patient patient NN cord-005453-4057qib7 16535 32 transplanted transplant VBN cord-005453-4057qib7 16535 33 from from IN cord-005453-4057qib7 16535 34 a a DT cord-005453-4057qib7 16535 35 MUD mud NN cord-005453-4057qib7 16535 36 lost lose VBD cord-005453-4057qib7 16535 37 the the DT cord-005453-4057qib7 16535 38 graft graft NN cord-005453-4057qib7 16535 39 due due IN cord-005453-4057qib7 16535 40 to to IN cord-005453-4057qib7 16535 41 hemophagocytosis hemophagocytosis NNP cord-005453-4057qib7 16535 42 , , , cord-005453-4057qib7 16535 43 the the DT cord-005453-4057qib7 16535 44 probability probability NN cord-005453-4057qib7 16535 45 of of IN cord-005453-4057qib7 16535 46 event event NN cord-005453-4057qib7 16535 47 - - HYPH cord-005453-4057qib7 16535 48 free free JJ cord-005453-4057qib7 16535 49 survival survival NN cord-005453-4057qib7 16535 50 was be VBD cord-005453-4057qib7 16535 51 89,5 89,5 CD cord-005453-4057qib7 16535 52 % % NN cord-005453-4057qib7 16535 53 after after IN cord-005453-4057qib7 16535 54 HSCT HSCT NNP cord-005453-4057qib7 16535 55 from from IN cord-005453-4057qib7 16535 56 MSD MSD NNP cord-005453-4057qib7 16535 57 / / SYM cord-005453-4057qib7 16535 58 MFD MFD NNP cord-005453-4057qib7 16535 59 and and CC cord-005453-4057qib7 16535 60 83,9 83,9 CD cord-005453-4057qib7 16535 61 % % NN cord-005453-4057qib7 16535 62 from from IN cord-005453-4057qib7 16535 63 MUD/ MUD/ NNP cord-005453-4057qib7 16536 1 MMUD.Altogether mmud.altogether DT cord-005453-4057qib7 16536 2 34/36 34/36 CD cord-005453-4057qib7 16536 3 patients patient NNS cord-005453-4057qib7 16536 4 ( ( -LRB- cord-005453-4057qib7 16536 5 94,4 94,4 CD cord-005453-4057qib7 16536 6 % % NN cord-005453-4057qib7 16536 7 ) ) -RRB- cord-005453-4057qib7 16536 8 are be VBP cord-005453-4057qib7 16536 9 alive alive JJ cord-005453-4057qib7 16536 10 and and CC cord-005453-4057qib7 16536 11 transfusion transfusion NN cord-005453-4057qib7 16536 12 - - HYPH cord-005453-4057qib7 16536 13 independent independent JJ cord-005453-4057qib7 16536 14 with with IN cord-005453-4057qib7 16536 15 complete complete JJ cord-005453-4057qib7 16536 16 donor donor NN cord-005453-4057qib7 16536 17 chimerism chimerism NN cord-005453-4057qib7 16536 18 two two CD cord-005453-4057qib7 16536 19 years year NNS cord-005453-4057qib7 16536 20 after after IN cord-005453-4057qib7 16536 21 HSCT HSCT NNP cord-005453-4057qib7 16536 22 ; ; : cord-005453-4057qib7 16536 23 resulting result VBG cord-005453-4057qib7 16536 24 in in IN cord-005453-4057qib7 16536 25 an an DT cord-005453-4057qib7 16536 26 overall overall JJ cord-005453-4057qib7 16536 27 survival survival NN cord-005453-4057qib7 16536 28 probability probability NN cord-005453-4057qib7 16536 29 of of IN cord-005453-4057qib7 16536 30 93,1 93,1 CD cord-005453-4057qib7 16536 31 % % NN cord-005453-4057qib7 16536 32 . . . cord-005453-4057qib7 16537 1 In in IN cord-005453-4057qib7 16537 2 contrast contrast NN cord-005453-4057qib7 16537 3 , , , cord-005453-4057qib7 16537 4 overall overall JJ cord-005453-4057qib7 16537 5 survival survival NN cord-005453-4057qib7 16537 6 probability probability NN cord-005453-4057qib7 16537 7 was be VBD cord-005453-4057qib7 16537 8 100 100 CD cord-005453-4057qib7 16537 9 % % NN cord-005453-4057qib7 16537 10 in in IN cord-005453-4057qib7 16537 11 the the DT cord-005453-4057qib7 16537 12 group group NN cord-005453-4057qib7 16537 13 of of IN cord-005453-4057qib7 16537 14 patients patient NNS cord-005453-4057qib7 16537 15 transplanted transplant VBN cord-005453-4057qib7 16537 16 from from IN cord-005453-4057qib7 16537 17 MSD MSD NNP cord-005453-4057qib7 16537 18 / / SYM cord-005453-4057qib7 16537 19 MFD MFD NNP cord-005453-4057qib7 16537 20 and and CC cord-005453-4057qib7 16537 21 80,1 80,1 CD cord-005453-4057qib7 16537 22 % % NN cord-005453-4057qib7 16537 23 in in IN cord-005453-4057qib7 16537 24 patients patient NNS cord-005453-4057qib7 16537 25 transplanted transplant VBN cord-005453-4057qib7 16537 26 from from IN cord-005453-4057qib7 16537 27 MUD/ MUD/ NNP cord-005453-4057qib7 16537 28 MMUD MMUD NNP cord-005453-4057qib7 16537 29 after after IN cord-005453-4057qib7 16537 30 2 2 CD cord-005453-4057qib7 16537 31 years year NNS cord-005453-4057qib7 16537 32 . . . cord-005453-4057qib7 16538 1 There there EX cord-005453-4057qib7 16538 2 were be VBD cord-005453-4057qib7 16538 3 2 2 CD cord-005453-4057qib7 16538 4 patients patient NNS cord-005453-4057qib7 16538 5 with with IN cord-005453-4057qib7 16538 6 thalassemia thalassemia NN cord-005453-4057qib7 16538 7 ( ( -LRB- cord-005453-4057qib7 16538 8 6,9 6,9 CD cord-005453-4057qib7 16538 9 % % NN cord-005453-4057qib7 16538 10 ) ) -RRB- cord-005453-4057qib7 16538 11 who who WP cord-005453-4057qib7 16538 12 died die VBD cord-005453-4057qib7 16538 13 from from IN cord-005453-4057qib7 16538 14 transplantation transplantation NN cord-005453-4057qib7 16538 15 - - HYPH cord-005453-4057qib7 16538 16 related relate VBN cord-005453-4057qib7 16538 17 causes cause NNS cord-005453-4057qib7 16538 18 . . . cord-005453-4057qib7 16539 1 The the DT cord-005453-4057qib7 16539 2 first first JJ cord-005453-4057qib7 16539 3 patient patient NN cord-005453-4057qib7 16539 4 died die VBD cord-005453-4057qib7 16539 5 13 13 CD cord-005453-4057qib7 16539 6 days day NNS cord-005453-4057qib7 16539 7 after after IN cord-005453-4057qib7 16539 8 HSCT HSCT NNP cord-005453-4057qib7 16539 9 from from IN cord-005453-4057qib7 16539 10 a a DT cord-005453-4057qib7 16539 11 MMUD MMUD NNP cord-005453-4057qib7 16539 12 due due JJ cord-005453-4057qib7 16539 13 to to IN cord-005453-4057qib7 16539 14 candida candida NN cord-005453-4057qib7 16539 15 sepsis sepsis NN cord-005453-4057qib7 16539 16 with with IN cord-005453-4057qib7 16539 17 pulseless pulseless JJ cord-005453-4057qib7 16539 18 electrical electrical JJ cord-005453-4057qib7 16539 19 activity activity NN cord-005453-4057qib7 16539 20 resulting result VBG cord-005453-4057qib7 16539 21 from from IN cord-005453-4057qib7 16539 22 cardiac cardiac JJ cord-005453-4057qib7 16539 23 iron iron NN cord-005453-4057qib7 16539 24 overload overload NN cord-005453-4057qib7 16539 25 . . . cord-005453-4057qib7 16540 1 The the DT cord-005453-4057qib7 16540 2 second second JJ cord-005453-4057qib7 16540 3 patient patient NN cord-005453-4057qib7 16540 4 died die VBD cord-005453-4057qib7 16540 5 5 5 CD cord-005453-4057qib7 16540 6 months month NNS cord-005453-4057qib7 16540 7 after after IN cord-005453-4057qib7 16540 8 HSCT HSCT NNP cord-005453-4057qib7 16540 9 from from IN cord-005453-4057qib7 16540 10 a a DT cord-005453-4057qib7 16540 11 MUD mud NN cord-005453-4057qib7 16540 12 due due JJ cord-005453-4057qib7 16540 13 to to IN cord-005453-4057qib7 16540 14 graft graft NN cord-005453-4057qib7 16540 15 failure failure NN cord-005453-4057qib7 16540 16 . . . cord-005453-4057qib7 16541 1 Conclusions conclusion NNS cord-005453-4057qib7 16541 2 : : : cord-005453-4057qib7 16541 3 HSCT HSCT NNP cord-005453-4057qib7 16541 4 from from IN cord-005453-4057qib7 16541 5 MUD MUD NNP cord-005453-4057qib7 16541 6 and and CC cord-005453-4057qib7 16541 7 MMUD MMUD NNP cord-005453-4057qib7 16541 8 is be VBZ cord-005453-4057qib7 16541 9 a a DT cord-005453-4057qib7 16541 10 feasible feasible JJ cord-005453-4057qib7 16541 11 therapy therapy NN cord-005453-4057qib7 16541 12 option option NN cord-005453-4057qib7 16541 13 for for IN cord-005453-4057qib7 16541 14 patients patient NNS cord-005453-4057qib7 16541 15 with with IN cord-005453-4057qib7 16541 16 transfusion transfusion NN cord-005453-4057qib7 16541 17 dependent dependent JJ cord-005453-4057qib7 16541 18 anemia anemia NN cord-005453-4057qib7 16541 19 . . . cord-005453-4057qib7 16542 1 Nevertheless nevertheless RB cord-005453-4057qib7 16542 2 , , , cord-005453-4057qib7 16542 3 it -PRON- PRP cord-005453-4057qib7 16542 4 should should MD cord-005453-4057qib7 16542 5 be be VB cord-005453-4057qib7 16542 6 noted note VBN cord-005453-4057qib7 16542 7 that that IN cord-005453-4057qib7 16542 8 iron iron NN cord-005453-4057qib7 16542 9 overload overload NN cord-005453-4057qib7 16542 10 can can MD cord-005453-4057qib7 16542 11 cause cause VB cord-005453-4057qib7 16542 12 severe severe JJ cord-005453-4057qib7 16542 13 complications complication NNS cord-005453-4057qib7 16542 14 ; ; : cord-005453-4057qib7 16542 15 therefore therefore RB cord-005453-4057qib7 16542 16 , , , cord-005453-4057qib7 16542 17 measurement measurement NN cord-005453-4057qib7 16542 18 of of IN cord-005453-4057qib7 16542 19 liver liver NN cord-005453-4057qib7 16542 20 and and CC cord-005453-4057qib7 16542 21 heart heart NN cord-005453-4057qib7 16542 22 iron iron NN cord-005453-4057qib7 16542 23 concentration concentration NN cord-005453-4057qib7 16542 24 through through IN cord-005453-4057qib7 16542 25 MRI MRI NNP cord-005453-4057qib7 16542 26 prior prior RB cord-005453-4057qib7 16542 27 to to IN cord-005453-4057qib7 16542 28 HSCT HSCT NNP cord-005453-4057qib7 16542 29 as as RB cord-005453-4057qib7 16542 30 well well RB cord-005453-4057qib7 16542 31 as as IN cord-005453-4057qib7 16542 32 phlebotomy phlebotomy NN cord-005453-4057qib7 16542 33 after after IN cord-005453-4057qib7 16542 34 transplantation transplantation NN cord-005453-4057qib7 16542 35 are be VBP cord-005453-4057qib7 16542 36 advisable advisable JJ cord-005453-4057qib7 16542 37 . . . cord-005453-4057qib7 16543 1 Disclosure disclosure NN cord-005453-4057qib7 16543 2 : : : cord-005453-4057qib7 16544 1 Novartis Novartis NNP cord-005453-4057qib7 16544 2 ( ( -LRB- cord-005453-4057qib7 16544 3 consultancy consultancy NN cord-005453-4057qib7 16544 4 : : : cord-005453-4057qib7 16544 5 included include VBN cord-005453-4057qib7 16544 6 expert expert JJ cord-005453-4057qib7 16544 7 testimony testimony NN cord-005453-4057qib7 16544 8 , , , cord-005453-4057qib7 16544 9 speaker speaker NNP cord-005453-4057qib7 16544 10 bureau bureau NNP cord-005453-4057qib7 16544 11 , , , cord-005453-4057qib7 16544 12 Honoraria Honoraria NNP cord-005453-4057qib7 16544 13 ) ) -RRB- cord-005453-4057qib7 16544 14 , , , cord-005453-4057qib7 16544 15 Medac Medac NNP cord-005453-4057qib7 16544 16 ( ( -LRB- cord-005453-4057qib7 16544 17 Research Research NNP cord-005453-4057qib7 16544 18 Funding Funding NNP cord-005453-4057qib7 16544 19 , , , cord-005453-4057qib7 16544 20 Patents Patents NNPS cord-005453-4057qib7 16544 21 and and CC cord-005453-4057qib7 16544 22 Royalties Royalties NNPS cord-005453-4057qib7 16544 23 ) ) -RRB- cord-005453-4057qib7 16544 24 , , , cord-005453-4057qib7 16544 25 Riemser Riemser NNP cord-005453-4057qib7 16544 26 ( ( -LRB- cord-005453-4057qib7 16544 27 Research Research NNP cord-005453-4057qib7 16544 28 Funding Funding NNP cord-005453-4057qib7 16544 29 ) ) -RRB- cord-005453-4057qib7 16544 30 , , , cord-005453-4057qib7 16544 31 Neovii Neovii NNP cord-005453-4057qib7 16544 32 ( ( -LRB- cord-005453-4057qib7 16544 33 Research Research NNP cord-005453-4057qib7 16544 34 Funding Funding NNP cord-005453-4057qib7 16544 35 ) ) -RRB- cord-005453-4057qib7 16544 36 , , . cord-005453-4057qib7 16545 1 Amgen Amgen NNP cord-005453-4057qib7 16545 2 ( ( -LRB- cord-005453-4057qib7 16545 3 Honoraria Honoraria NNP cord-005453-4057qib7 16545 4 ) ) -RRB- cord-005453-4057qib7 16545 5 Background background NN cord-005453-4057qib7 16545 6 : : : cord-005453-4057qib7 16546 1 The the DT cord-005453-4057qib7 16546 2 therapeutic therapeutic JJ cord-005453-4057qib7 16546 3 options option NNS cord-005453-4057qib7 16546 4 for for IN cord-005453-4057qib7 16546 5 patients patient NNS cord-005453-4057qib7 16546 6 with with IN cord-005453-4057qib7 16546 7 Hodgkin´s hodgkin´ NNS cord-005453-4057qib7 16546 8 disease disease NN cord-005453-4057qib7 16546 9 who who WP cord-005453-4057qib7 16546 10 relapse relapse VBP cord-005453-4057qib7 16546 11 after after IN cord-005453-4057qib7 16546 12 first first JJ cord-005453-4057qib7 16546 13 high high JJ cord-005453-4057qib7 16546 14 - - HYPH cord-005453-4057qib7 16546 15 dose dose NN cord-005453-4057qib7 16546 16 chemotherapy chemotherapy NN cord-005453-4057qib7 16546 17 with with IN cord-005453-4057qib7 16546 18 autologous autologous JJ cord-005453-4057qib7 16546 19 stem stem NN cord-005453-4057qib7 16546 20 cell cell NN cord-005453-4057qib7 16546 21 ( ( -LRB- cord-005453-4057qib7 16546 22 1 1 CD cord-005453-4057qib7 16546 23 st st NNP cord-005453-4057qib7 16546 24 ASCT ASCT NNP cord-005453-4057qib7 16546 25 ) ) -RRB- cord-005453-4057qib7 16546 26 support support NN cord-005453-4057qib7 16546 27 are be VBP cord-005453-4057qib7 16546 28 limited limited JJ cord-005453-4057qib7 16546 29 . . . cord-005453-4057qib7 16547 1 Allogeneic allogeneic IN cord-005453-4057qib7 16547 2 stem stem VBP cord-005453-4057qib7 16547 3 cell cell NN cord-005453-4057qib7 16547 4 transplantation transplantation NN cord-005453-4057qib7 16547 5 in in IN cord-005453-4057qib7 16547 6 this this DT cord-005453-4057qib7 16547 7 setting setting NN cord-005453-4057qib7 16547 8 is be VBZ cord-005453-4057qib7 16547 9 associated associate VBN cord-005453-4057qib7 16547 10 with with IN cord-005453-4057qib7 16547 11 a a DT cord-005453-4057qib7 16547 12 high high JJ cord-005453-4057qib7 16547 13 level level NN cord-005453-4057qib7 16547 14 of of IN cord-005453-4057qib7 16547 15 transplant transplant NN cord-005453-4057qib7 16547 16 - - HYPH cord-005453-4057qib7 16547 17 dependent dependent JJ cord-005453-4057qib7 16547 18 mortality mortality NN cord-005453-4057qib7 16547 19 rates rate NNS cord-005453-4057qib7 16547 20 in in IN cord-005453-4057qib7 16547 21 excess excess NN cord-005453-4057qib7 16547 22 of of IN cord-005453-4057qib7 16547 23 50 50 CD cord-005453-4057qib7 16547 24 - - SYM cord-005453-4057qib7 16547 25 65 65 CD cord-005453-4057qib7 16547 26 % % NN cord-005453-4057qib7 16547 27 . . . cord-005453-4057qib7 16548 1 New new JJ cord-005453-4057qib7 16548 2 agent agent NN cord-005453-4057qib7 16548 3 , , , cord-005453-4057qib7 16548 4 such such JJ cord-005453-4057qib7 16548 5 as as IN cord-005453-4057qib7 16548 6 brentuximab brentuximab NNP cord-005453-4057qib7 16548 7 vedotin vedotin NNP cord-005453-4057qib7 16548 8 , , , cord-005453-4057qib7 16548 9 have have VBP cord-005453-4057qib7 16548 10 been be VBN cord-005453-4057qib7 16548 11 approved approve VBN cord-005453-4057qib7 16548 12 for for IN cord-005453-4057qib7 16548 13 the the DT cord-005453-4057qib7 16548 14 treatment treatment NN cord-005453-4057qib7 16548 15 of of IN cord-005453-4057qib7 16548 16 these these DT cord-005453-4057qib7 16548 17 patients patient NNS cord-005453-4057qib7 16548 18 , , , cord-005453-4057qib7 16548 19 however however RB cord-005453-4057qib7 16548 20 , , , cord-005453-4057qib7 16548 21 their -PRON- PRP$ cord-005453-4057qib7 16548 22 efficacy efficacy NN cord-005453-4057qib7 16548 23 to to TO cord-005453-4057qib7 16548 24 provide provide VB cord-005453-4057qib7 16548 25 longterm longterm JJ cord-005453-4057qib7 16548 26 control control NN cord-005453-4057qib7 16548 27 or or CC cord-005453-4057qib7 16548 28 cure cure NN cord-005453-4057qib7 16548 29 is be VBZ cord-005453-4057qib7 16548 30 still still RB cord-005453-4057qib7 16548 31 unknown unknown JJ cord-005453-4057qib7 16548 32 . . . cord-005453-4057qib7 16549 1 A a DT cord-005453-4057qib7 16549 2 second second JJ cord-005453-4057qib7 16549 3 autologous autologous JJ cord-005453-4057qib7 16549 4 stem stem NN cord-005453-4057qib7 16549 5 cell cell NN cord-005453-4057qib7 16549 6 ( ( -LRB- cord-005453-4057qib7 16549 7 2 2 CD cord-005453-4057qib7 16549 8 nd nd NNP cord-005453-4057qib7 16549 9 ASCT ASCT NNP cord-005453-4057qib7 16549 10 ) ) -RRB- cord-005453-4057qib7 16549 11 has have VBZ cord-005453-4057qib7 16549 12 historically historically RB cord-005453-4057qib7 16549 13 been be VBN cord-005453-4057qib7 16549 14 considered consider VBN cord-005453-4057qib7 16549 15 as as IN cord-005453-4057qib7 16549 16 an an DT cord-005453-4057qib7 16549 17 option option NN cord-005453-4057qib7 16549 18 only only RB cord-005453-4057qib7 16549 19 in in IN cord-005453-4057qib7 16549 20 a a DT cord-005453-4057qib7 16549 21 small small JJ cord-005453-4057qib7 16549 22 group group NN cord-005453-4057qib7 16549 23 of of IN cord-005453-4057qib7 16549 24 patients patient NNS cord-005453-4057qib7 16549 25 so so IN cord-005453-4057qib7 16549 26 the the DT cord-005453-4057qib7 16549 27 published publish VBN cord-005453-4057qib7 16549 28 experience experience NN cord-005453-4057qib7 16549 29 is be VBZ cord-005453-4057qib7 16549 30 scarce scarce JJ cord-005453-4057qib7 16549 31 . . . cord-005453-4057qib7 16550 1 We -PRON- PRP cord-005453-4057qib7 16550 2 report report VBP cord-005453-4057qib7 16550 3 our -PRON- PRP$ cord-005453-4057qib7 16550 4 institution´s institution´s NNP cord-005453-4057qib7 16550 5 experience experience NN cord-005453-4057qib7 16550 6 with with IN cord-005453-4057qib7 16550 7 second second JJ cord-005453-4057qib7 16550 8 autologous autologous JJ cord-005453-4057qib7 16550 9 transplants transplant NNS cord-005453-4057qib7 16550 10 in in IN cord-005453-4057qib7 16550 11 this this DT cord-005453-4057qib7 16550 12 patient patient JJ cord-005453-4057qib7 16550 13 population population NN cord-005453-4057qib7 16550 14 . . . cord-005453-4057qib7 16551 1 Methods method NNS cord-005453-4057qib7 16551 2 : : : cord-005453-4057qib7 16551 3 We -PRON- PRP cord-005453-4057qib7 16551 4 evaluated evaluate VBD cord-005453-4057qib7 16551 5 the the DT cord-005453-4057qib7 16551 6 outcome outcome NN cord-005453-4057qib7 16551 7 of of IN cord-005453-4057qib7 16551 8 16 16 CD cord-005453-4057qib7 16551 9 adult adult NN cord-005453-4057qib7 16551 10 patients patient NNS cord-005453-4057qib7 16551 11 ( ( -LRB- cord-005453-4057qib7 16551 12 7 7 CD cord-005453-4057qib7 16551 13 ( ( -LRB- cord-005453-4057qib7 16551 14 44 44 CD cord-005453-4057qib7 16551 15 % % NN cord-005453-4057qib7 16551 16 ) ) -RRB- cord-005453-4057qib7 16551 17 female female NN cord-005453-4057qib7 16551 18 and and CC cord-005453-4057qib7 16551 19 9 9 CD cord-005453-4057qib7 16551 20 ( ( -LRB- cord-005453-4057qib7 16551 21 56 56 CD cord-005453-4057qib7 16551 22 % % NN cord-005453-4057qib7 16551 23 ) ) -RRB- cord-005453-4057qib7 16551 24 male male NN cord-005453-4057qib7 16551 25 ) ) -RRB- cord-005453-4057qib7 16551 26 , , , cord-005453-4057qib7 16551 27 who who WP cord-005453-4057qib7 16551 28 received receive VBD cord-005453-4057qib7 16551 29 an an DT cord-005453-4057qib7 16551 30 2 2 CD cord-005453-4057qib7 16551 31 nd nd NNP cord-005453-4057qib7 16551 32 ASCT ASCT NNP cord-005453-4057qib7 16551 33 between between IN cord-005453-4057qib7 16551 34 10/2013 10/2013 CD cord-005453-4057qib7 16551 35 and and CC cord-005453-4057qib7 16551 36 08/2018 08/2018 CD cord-005453-4057qib7 16551 37 . . . cord-005453-4057qib7 16552 1 Planned plan VBN cord-005453-4057qib7 16552 2 tandem tandem NN cord-005453-4057qib7 16552 3 ASCT ASCT NNP cord-005453-4057qib7 16552 4 were be VBD cord-005453-4057qib7 16552 5 excluded exclude VBN cord-005453-4057qib7 16552 6 . . . cord-005453-4057qib7 16553 1 The the DT cord-005453-4057qib7 16553 2 median median JJ cord-005453-4057qib7 16553 3 age age NN cord-005453-4057qib7 16553 4 at at IN cord-005453-4057qib7 16553 5 2 2 CD cord-005453-4057qib7 16553 6 nd nd NNP cord-005453-4057qib7 16553 7 ASCT ASCT NNP cord-005453-4057qib7 16553 8 was be VBD cord-005453-4057qib7 16553 9 32 32 CD cord-005453-4057qib7 16553 10 years year NNS cord-005453-4057qib7 16554 1 ( ( -LRB- cord-005453-4057qib7 16554 2 range range NNP cord-005453-4057qib7 16554 3 21 21 CD cord-005453-4057qib7 16554 4 - - SYM cord-005453-4057qib7 16554 5 54 54 CD cord-005453-4057qib7 16554 6 ) ) -RRB- cord-005453-4057qib7 16554 7 , , , cord-005453-4057qib7 16554 8 15 15 CD cord-005453-4057qib7 16554 9 ( ( -LRB- cord-005453-4057qib7 16554 10 94 94 CD cord-005453-4057qib7 16554 11 % % NN cord-005453-4057qib7 16554 12 ) ) -RRB- cord-005453-4057qib7 16554 13 patients patient NNS cord-005453-4057qib7 16554 14 had have VBD cord-005453-4057qib7 16554 15 a a DT cord-005453-4057qib7 16554 16 Karnofsky Karnofsky NNP cord-005453-4057qib7 16554 17 performance performance NN cord-005453-4057qib7 16554 18 score score NN cord-005453-4057qib7 16554 19 ≥80 ≥80 CD cord-005453-4057qib7 16554 20 % % NN cord-005453-4057qib7 16554 21 . . . cord-005453-4057qib7 16555 1 12 12 CD cord-005453-4057qib7 16555 2 ( ( -LRB- cord-005453-4057qib7 16555 3 75 75 CD cord-005453-4057qib7 16555 4 % % NN cord-005453-4057qib7 16555 5 ) ) -RRB- cord-005453-4057qib7 16555 6 patients patient NNS cord-005453-4057qib7 16555 7 were be VBD cord-005453-4057qib7 16555 8 in in IN cord-005453-4057qib7 16555 9 complete complete JJ cord-005453-4057qib7 16555 10 remission remission NN cord-005453-4057qib7 16555 11 ( ( -LRB- cord-005453-4057qib7 16555 12 CR CR NNP cord-005453-4057qib7 16555 13 ) ) -RRB- cord-005453-4057qib7 16555 14 and and CC cord-005453-4057qib7 16555 15 4 4 CD cord-005453-4057qib7 16555 16 ( ( -LRB- cord-005453-4057qib7 16555 17 25 25 CD cord-005453-4057qib7 16555 18 % % NN cord-005453-4057qib7 16555 19 ) ) -RRB- cord-005453-4057qib7 16555 20 patients patient NNS cord-005453-4057qib7 16555 21 were be VBD cord-005453-4057qib7 16555 22 in in IN cord-005453-4057qib7 16555 23 partial partial JJ cord-005453-4057qib7 16555 24 remission remission NN cord-005453-4057qib7 16555 25 ( ( -LRB- cord-005453-4057qib7 16555 26 PR PR NNP cord-005453-4057qib7 16555 27 ) ) -RRB- cord-005453-4057qib7 16555 28 at at IN cord-005453-4057qib7 16555 29 day day NN cord-005453-4057qib7 16555 30 100 100 CD cord-005453-4057qib7 16555 31 after after IN cord-005453-4057qib7 16555 32 1 1 CD cord-005453-4057qib7 16555 33 st st NNP cord-005453-4057qib7 16555 34 ASCT ASCT NNP cord-005453-4057qib7 16555 35 . . . cord-005453-4057qib7 16556 1 Seven seven CD cord-005453-4057qib7 16556 2 ( ( -LRB- cord-005453-4057qib7 16556 3 44 44 CD cord-005453-4057qib7 16556 4 % % NN cord-005453-4057qib7 16556 5 ) ) -RRB- cord-005453-4057qib7 16556 6 relapses relapse NNS cord-005453-4057qib7 16556 7 within within IN cord-005453-4057qib7 16556 8 12 12 CD cord-005453-4057qib7 16556 9 months month NNS cord-005453-4057qib7 16556 10 after after IN cord-005453-4057qib7 16556 11 1 1 CD cord-005453-4057qib7 16556 12 st st NNP cord-005453-4057qib7 16556 13 ASCT ASCT NNP cord-005453-4057qib7 16556 14 . . . cord-005453-4057qib7 16557 1 Patients patient NNS cord-005453-4057qib7 16557 2 received receive VBD cord-005453-4057qib7 16557 3 a a DT cord-005453-4057qib7 16557 4 median median NN cord-005453-4057qib7 16557 5 of of IN cord-005453-4057qib7 16557 6 1 1 CD cord-005453-4057qib7 16557 7 ( ( -LRB- cord-005453-4057qib7 16557 8 0 0 CD cord-005453-4057qib7 16557 9 - - SYM cord-005453-4057qib7 16557 10 3 3 CD cord-005453-4057qib7 16557 11 ) ) -RRB- cord-005453-4057qib7 16557 12 treatment treatment NN cord-005453-4057qib7 16557 13 lines line NNS cord-005453-4057qib7 16557 14 between between IN cord-005453-4057qib7 16557 15 1 1 CD cord-005453-4057qib7 16557 16 st st NNP cord-005453-4057qib7 16557 17 ASCT ASCT NNP cord-005453-4057qib7 16557 18 and and CC cord-005453-4057qib7 16557 19 2 2 CD cord-005453-4057qib7 16557 20 nd nd NNP cord-005453-4057qib7 16557 21 ASCT ASCT NNP cord-005453-4057qib7 16557 22 . . . cord-005453-4057qib7 16558 1 Only only RB cord-005453-4057qib7 16558 2 4 4 CD cord-005453-4057qib7 16558 3 ( ( -LRB- cord-005453-4057qib7 16558 4 25 25 CD cord-005453-4057qib7 16558 5 % % NN cord-005453-4057qib7 16558 6 ) ) -RRB- cord-005453-4057qib7 16558 7 patients patient NNS cord-005453-4057qib7 16558 8 received receive VBD cord-005453-4057qib7 16558 9 brentuximab brentuximab NNP cord-005453-4057qib7 16558 10 vedotin vedotin NNP cord-005453-4057qib7 16558 11 and and CC cord-005453-4057qib7 16558 12 none none NN cord-005453-4057qib7 16558 13 of of IN cord-005453-4057qib7 16558 14 the the DT cord-005453-4057qib7 16558 15 patients patient NNS cord-005453-4057qib7 16558 16 in in IN cord-005453-4057qib7 16558 17 our -PRON- PRP$ cord-005453-4057qib7 16558 18 series series NN cord-005453-4057qib7 16558 19 received receive VBD cord-005453-4057qib7 16558 20 checkpoint checkpoint NN cord-005453-4057qib7 16558 21 inhibitors inhibitor NNS cord-005453-4057qib7 16558 22 as as IN cord-005453-4057qib7 16558 23 salvage salvage NN cord-005453-4057qib7 16558 24 after after IN cord-005453-4057qib7 16558 25 1 1 CD cord-005453-4057qib7 16558 26 st st NNP cord-005453-4057qib7 16558 27 ASCT ASCT NNP cord-005453-4057qib7 16558 28 . . . cord-005453-4057qib7 16559 1 The the DT cord-005453-4057qib7 16559 2 median median JJ cord-005453-4057qib7 16559 3 interval interval NN cord-005453-4057qib7 16559 4 from from IN cord-005453-4057qib7 16559 5 1 1 CD cord-005453-4057qib7 16559 6 st st NNP cord-005453-4057qib7 16559 7 ASCT ASCT NNP cord-005453-4057qib7 16559 8 to to TO cord-005453-4057qib7 16559 9 relapse relapse VB cord-005453-4057qib7 16559 10 / / SYM cord-005453-4057qib7 16559 11 progression progression NN cord-005453-4057qib7 16559 12 was12,9 was12,9 NN cord-005453-4057qib7 16559 13 months month NNS cord-005453-4057qib7 16560 1 ( ( -LRB- cord-005453-4057qib7 16560 2 range range NNP cord-005453-4057qib7 16560 3 2,9 2,9 CD cord-005453-4057qib7 16560 4 - - HYPH cord-005453-4057qib7 16560 5 133,3 133,3 CD cord-005453-4057qib7 16560 6 ) ) -RRB- cord-005453-4057qib7 16560 7 . . . cord-005453-4057qib7 16561 1 The the DT cord-005453-4057qib7 16561 2 median median JJ cord-005453-4057qib7 16561 3 interval interval NN cord-005453-4057qib7 16561 4 from from IN cord-005453-4057qib7 16561 5 relapse relapse NN cord-005453-4057qib7 16561 6 / / SYM cord-005453-4057qib7 16561 7 progression progression NN cord-005453-4057qib7 16561 8 to to IN cord-005453-4057qib7 16561 9 2 2 CD cord-005453-4057qib7 16561 10 nd nd NNP cord-005453-4057qib7 16561 11 ASCT ASCT NNP cord-005453-4057qib7 16561 12 was be VBD cord-005453-4057qib7 16561 13 9,2 9,2 CD cord-005453-4057qib7 16561 14 months month NNS cord-005453-4057qib7 16562 1 ( ( -LRB- cord-005453-4057qib7 16562 2 range range NNP cord-005453-4057qib7 16562 3 1,4 1,4 CD cord-005453-4057qib7 16562 4 - - HYPH cord-005453-4057qib7 16562 5 46,6 46,6 CD cord-005453-4057qib7 16562 6 ) ) -RRB- cord-005453-4057qib7 16562 7 . . . cord-005453-4057qib7 16563 1 All all DT cord-005453-4057qib7 16563 2 patients patient NNS cord-005453-4057qib7 16563 3 received receive VBD cord-005453-4057qib7 16563 4 BEAM BEAM NNP cord-005453-4057qib7 16563 5 as as IN cord-005453-4057qib7 16563 6 the the DT cord-005453-4057qib7 16563 7 conditioning conditioning NN cord-005453-4057qib7 16563 8 regimen regimen NN cord-005453-4057qib7 16563 9 for for IN cord-005453-4057qib7 16563 10 1 1 CD cord-005453-4057qib7 16563 11 st st NNP cord-005453-4057qib7 16563 12 ASCT ASCT NNP cord-005453-4057qib7 16563 13 , , , cord-005453-4057qib7 16563 14 and and CC cord-005453-4057qib7 16563 15 BeEAM beeam RB cord-005453-4057qib7 16563 16 as as IN cord-005453-4057qib7 16563 17 the the DT cord-005453-4057qib7 16563 18 conditioning conditioning NN cord-005453-4057qib7 16563 19 regimen regimen NN cord-005453-4057qib7 16563 20 for for IN cord-005453-4057qib7 16563 21 2 2 CD cord-005453-4057qib7 16563 22 nd nd NNP cord-005453-4057qib7 16563 23 ASCT.Results asct.results CD cord-005453-4057qib7 16563 24 : : : cord-005453-4057qib7 16563 25 The the DT cord-005453-4057qib7 16563 26 median median JJ cord-005453-4057qib7 16563 27 time time NN cord-005453-4057qib7 16563 28 to to IN cord-005453-4057qib7 16563 29 neutrophil neutrophil NN cord-005453-4057qib7 16563 30 recovery recovery NN cord-005453-4057qib7 16563 31 ( ( -LRB- cord-005453-4057qib7 16563 32 > > NFP cord-005453-4057qib7 16563 33 0.5x10 0.5x10 CD cord-005453-4057qib7 16563 34 9 9 CD cord-005453-4057qib7 16563 35 /L /L . cord-005453-4057qib7 16563 36 ) ) -RRB- cord-005453-4057qib7 16563 37 after after IN cord-005453-4057qib7 16563 38 2 2 CD cord-005453-4057qib7 16563 39 nd nd NNP cord-005453-4057qib7 16563 40 ASCT ASCT NNP cord-005453-4057qib7 16563 41 were be VBD cord-005453-4057qib7 16563 42 10 10 CD cord-005453-4057qib7 16563 43 days day NNS cord-005453-4057qib7 16563 44 ( ( -LRB- cord-005453-4057qib7 16564 1 range range NNP cord-005453-4057qib7 16564 2 8 8 CD cord-005453-4057qib7 16564 3 - - SYM cord-005453-4057qib7 16564 4 17 17 CD cord-005453-4057qib7 16564 5 ) ) -RRB- cord-005453-4057qib7 16564 6 . . . cord-005453-4057qib7 16565 1 Best good JJS cord-005453-4057qib7 16565 2 response response NN cord-005453-4057qib7 16565 3 at at IN cord-005453-4057qib7 16565 4 day day NN cord-005453-4057qib7 16565 5 100 100 CD cord-005453-4057qib7 16565 6 following follow VBG cord-005453-4057qib7 16565 7 2 2 CD cord-005453-4057qib7 16565 8 nd nd NNP cord-005453-4057qib7 16565 9 ASCT ASCT NNP cord-005453-4057qib7 16565 10 included include VBD cord-005453-4057qib7 16565 11 CR CR NNP cord-005453-4057qib7 16565 12 in in IN cord-005453-4057qib7 16565 13 12 12 CD cord-005453-4057qib7 16565 14 ( ( -LRB- cord-005453-4057qib7 16565 15 75 75 CD cord-005453-4057qib7 16565 16 % % NN cord-005453-4057qib7 16565 17 ) ) -RRB- cord-005453-4057qib7 16565 18 patients patient NNS cord-005453-4057qib7 16565 19 and and CC cord-005453-4057qib7 16565 20 PR PR NNP cord-005453-4057qib7 16565 21 in in IN cord-005453-4057qib7 16565 22 3 3 CD cord-005453-4057qib7 16565 23 ( ( -LRB- cord-005453-4057qib7 16565 24 19 19 CD cord-005453-4057qib7 16565 25 % % NN cord-005453-4057qib7 16565 26 ) ) -RRB- cord-005453-4057qib7 16565 27 ; ; : cord-005453-4057qib7 16565 28 1 1 CD cord-005453-4057qib7 16565 29 ( ( -LRB- cord-005453-4057qib7 16565 30 6 6 CD cord-005453-4057qib7 16565 31 % % NN cord-005453-4057qib7 16565 32 ) ) -RRB- cord-005453-4057qib7 16565 33 had have VBD cord-005453-4057qib7 16565 34 stable stable JJ cord-005453-4057qib7 16565 35 disease disease NN cord-005453-4057qib7 16565 36 . . . cord-005453-4057qib7 16566 1 3 3 LS cord-005453-4057qib7 16566 2 ( ( -LRB- cord-005453-4057qib7 16566 3 19 19 CD cord-005453-4057qib7 16566 4 % % NN cord-005453-4057qib7 16566 5 ) ) -RRB- cord-005453-4057qib7 16566 6 patients patient NNS cord-005453-4057qib7 16566 7 received receive VBD cord-005453-4057qib7 16566 8 brentuximab brentuximab NNP cord-005453-4057qib7 16566 9 vedotin vedotin NNP cord-005453-4057qib7 16566 10 and and CC cord-005453-4057qib7 16566 11 none none NN cord-005453-4057qib7 16566 12 of of IN cord-005453-4057qib7 16566 13 the the DT cord-005453-4057qib7 16566 14 patients patient NNS cord-005453-4057qib7 16566 15 received receive VBD cord-005453-4057qib7 16566 16 checkpoint checkpoint NN cord-005453-4057qib7 16566 17 inhibitors inhibitor NNS cord-005453-4057qib7 16566 18 after after IN cord-005453-4057qib7 16566 19 2 2 CD cord-005453-4057qib7 16566 20 nd nd NNP cord-005453-4057qib7 16566 21 ASCT ASCT NNP cord-005453-4057qib7 16566 22 . . . cord-005453-4057qib7 16567 1 14 14 CD cord-005453-4057qib7 16567 2 ( ( -LRB- cord-005453-4057qib7 16567 3 87,5 87,5 CD cord-005453-4057qib7 16567 4 % % NN cord-005453-4057qib7 16567 5 ) ) -RRB- cord-005453-4057qib7 16567 6 patients patient NNS cord-005453-4057qib7 16567 7 are be VBP cord-005453-4057qib7 16567 8 currently currently RB cord-005453-4057qib7 16567 9 alive alive JJ cord-005453-4057qib7 16567 10 , , , cord-005453-4057qib7 16567 11 with with IN cord-005453-4057qib7 16567 12 a a DT cord-005453-4057qib7 16567 13 median median JJ cord-005453-4057qib7 16567 14 follow follow NN cord-005453-4057qib7 16567 15 - - HYPH cord-005453-4057qib7 16567 16 up up NN cord-005453-4057qib7 16567 17 49,8 49,8 CD cord-005453-4057qib7 16567 18 months month NNS cord-005453-4057qib7 16568 1 ( ( -LRB- cord-005453-4057qib7 16568 2 range range NN cord-005453-4057qib7 16568 3 4,2 4,2 CD cord-005453-4057qib7 16568 4 - - HYPH cord-005453-4057qib7 16568 5 154,2).2 154,2).2 CD cord-005453-4057qib7 16568 6 patient patient NN cord-005453-4057qib7 16568 7 died die VBD cord-005453-4057qib7 16568 8 after after IN cord-005453-4057qib7 16568 9 2 2 CD cord-005453-4057qib7 16568 10 nd nd NNP cord-005453-4057qib7 16568 11 ASCT ASCT NNP cord-005453-4057qib7 16568 12 . . . cord-005453-4057qib7 16569 1 Causes cause NNS cord-005453-4057qib7 16569 2 of of IN cord-005453-4057qib7 16569 3 death death NN cord-005453-4057qib7 16569 4 were be VBD cord-005453-4057qib7 16569 5 HL HL NNP cord-005453-4057qib7 16569 6 progression progression NN cord-005453-4057qib7 16569 7 . . . cord-005453-4057qib7 16570 1 The the DT cord-005453-4057qib7 16570 2 5-year 5-year CD cord-005453-4057qib7 16570 3 overall overall JJ cord-005453-4057qib7 16570 4 survival survival NN cord-005453-4057qib7 16570 5 was be VBD cord-005453-4057qib7 16570 6 86%.Conclusions 86%.conclusions CD cord-005453-4057qib7 16570 7 : : : cord-005453-4057qib7 16571 1 The the DT cord-005453-4057qib7 16571 2 second second JJ cord-005453-4057qib7 16571 3 ASCT asct NN cord-005453-4057qib7 16571 4 in in IN cord-005453-4057qib7 16571 5 patients patient NNS cord-005453-4057qib7 16571 6 with with IN cord-005453-4057qib7 16571 7 a a DT cord-005453-4057qib7 16571 8 longterm longterm JJ cord-005453-4057qib7 16571 9 response response NN cord-005453-4057qib7 16571 10 after after IN cord-005453-4057qib7 16571 11 the the DT cord-005453-4057qib7 16571 12 first first JJ cord-005453-4057qib7 16571 13 ASCT ASCT NNP cord-005453-4057qib7 16571 14 may may MD cord-005453-4057qib7 16571 15 be be VB cord-005453-4057qib7 16571 16 the the DT cord-005453-4057qib7 16571 17 optimal optimal JJ cord-005453-4057qib7 16571 18 therapeutic therapeutic JJ cord-005453-4057qib7 16571 19 option option NN cord-005453-4057qib7 16571 20 , , , cord-005453-4057qib7 16571 21 the the DT cord-005453-4057qib7 16571 22 effectiveness effectiveness NN cord-005453-4057qib7 16571 23 of of IN cord-005453-4057qib7 16571 24 which which WDT cord-005453-4057qib7 16571 25 can can MD cord-005453-4057qib7 16571 26 be be VB cord-005453-4057qib7 16571 27 enhanced enhance VBN cord-005453-4057qib7 16571 28 by by IN cord-005453-4057qib7 16571 29 using use VBG cord-005453-4057qib7 16571 30 new new JJ cord-005453-4057qib7 16571 31 drugs drug NNS cord-005453-4057qib7 16571 32 , , , cord-005453-4057qib7 16571 33 such such JJ cord-005453-4057qib7 16571 34 as as IN cord-005453-4057qib7 16571 35 brentuximab brentuximab NNP cord-005453-4057qib7 16571 36 vedotin vedotin NNP cord-005453-4057qib7 16571 37 , , , cord-005453-4057qib7 16571 38 at at IN cord-005453-4057qib7 16571 39 all all DT cord-005453-4057qib7 16571 40 stages stage NNS cord-005453-4057qib7 16571 41 of of IN cord-005453-4057qib7 16571 42 treatment treatment NN cord-005453-4057qib7 16571 43 . . . cord-005453-4057qib7 16572 1 Disclosure disclosure NN cord-005453-4057qib7 16572 2 : : : cord-005453-4057qib7 16572 3 Nothing nothing NN cord-005453-4057qib7 16572 4 to to TO cord-005453-4057qib7 16572 5 declare declare VB cord-005453-4057qib7 16572 6 Effectiveness Effectiveness NNP cord-005453-4057qib7 16572 7 of of IN cord-005453-4057qib7 16572 8 chemo chemo NN cord-005453-4057qib7 16572 9 - - HYPH cord-005453-4057qib7 16572 10 G G NNP cord-005453-4057qib7 16572 11 - - HYPH cord-005453-4057qib7 16572 12 CSF csf NN cord-005453-4057qib7 16572 13 protocols protocol NNS cord-005453-4057qib7 16572 14 for for IN cord-005453-4057qib7 16572 15 mobilization mobilization NN cord-005453-4057qib7 16572 16 of of IN cord-005453-4057qib7 16572 17 peripheral peripheral JJ cord-005453-4057qib7 16572 18 stem stem NN cord-005453-4057qib7 16572 19 cells cell NNS cord-005453-4057qib7 16572 20 in in IN cord-005453-4057qib7 16572 21 patients patient NNS cord-005453-4057qib7 16572 22 with with IN cord-005453-4057qib7 16572 23 non non JJ cord-005453-4057qib7 16572 24 - - JJ cord-005453-4057qib7 16572 25 hodgkin hodgkin JJ cord-005453-4057qib7 16572 26 lymphomas lymphoma NNS cord-005453-4057qib7 16572 27 and and CC cord-005453-4057qib7 16572 28 hodgkin hodgkin NNP cord-005453-4057qib7 16572 29 disease disease NNP cord-005453-4057qib7 16572 30 - - HYPH cord-005453-4057qib7 16572 31 single single JJ cord-005453-4057qib7 16572 32 center center NN cord-005453-4057qib7 16572 33 experienceIlina experienceilina JJ cord-005453-4057qib7 16572 34 Micheva Micheva NNP cord-005453-4057qib7 16572 35 1 1 CD cord-005453-4057qib7 16572 36 , , , cord-005453-4057qib7 16572 37 Stela Stela NNP cord-005453-4057qib7 16572 38 Dimitrova Dimitrova NNP cord-005453-4057qib7 16572 39 1 1 CD cord-005453-4057qib7 16572 40 , , , cord-005453-4057qib7 16572 41 Vladimir Vladimir NNP cord-005453-4057qib7 16572 42 Gerov Gerov NNP cord-005453-4057qib7 16572 43 1 1 CD cord-005453-4057qib7 16572 44 , , , cord-005453-4057qib7 16572 45 Trifon Trifon NNP cord-005453-4057qib7 16572 46 Chervenkov Chervenkov NNP cord-005453-4057qib7 16572 47 2 2 CD cord-005453-4057qib7 16572 48 , , , cord-005453-4057qib7 16572 49 Liana Liana NNP cord-005453-4057qib7 16572 50 Gercheva Gercheva NNP cord-005453-4057qib7 16572 51 1 1 CD cord-005453-4057qib7 16572 52 , , , cord-005453-4057qib7 16572 53 Igor Igor NNP cord-005453-4057qib7 16572 54 Reznik Reznik NNP cord-005453-4057qib7 16572 55 1Background 1background CD cord-005453-4057qib7 16572 56 : : : cord-005453-4057qib7 16572 57 High high JJ cord-005453-4057qib7 16572 58 - - HYPH cord-005453-4057qib7 16572 59 dose dose NN cord-005453-4057qib7 16572 60 chemotherapy chemotherapy NN cord-005453-4057qib7 16572 61 and and CC cord-005453-4057qib7 16572 62 autologous autologous JJ cord-005453-4057qib7 16572 63 stem stem NN cord-005453-4057qib7 16572 64 cell cell NN cord-005453-4057qib7 16572 65 transplantation transplantation NN cord-005453-4057qib7 16572 66 ( ( -LRB- cord-005453-4057qib7 16572 67 ASCT ASCT NNP cord-005453-4057qib7 16572 68 ) ) -RRB- cord-005453-4057qib7 16572 69 play play VB cord-005453-4057qib7 16572 70 an an DT cord-005453-4057qib7 16572 71 important important JJ cord-005453-4057qib7 16572 72 role role NN cord-005453-4057qib7 16572 73 in in IN cord-005453-4057qib7 16572 74 achieving achieve VBG cord-005453-4057qib7 16572 75 long long JJ cord-005453-4057qib7 16572 76 - - HYPH cord-005453-4057qib7 16572 77 term term NN cord-005453-4057qib7 16572 78 remission remission NN cord-005453-4057qib7 16572 79 in in IN cord-005453-4057qib7 16572 80 patients patient NNS cord-005453-4057qib7 16572 81 with with IN cord-005453-4057qib7 16572 82 non non JJ cord-005453-4057qib7 16572 83 - - JJ cord-005453-4057qib7 16572 84 Hodgkin hodgkin JJ cord-005453-4057qib7 16572 85 lymphoma lymphoma NN cord-005453-4057qib7 16572 86 ( ( -LRB- cord-005453-4057qib7 16572 87 NHL NHL NNP cord-005453-4057qib7 16572 88 ) ) -RRB- cord-005453-4057qib7 16572 89 and and CC cord-005453-4057qib7 16572 90 Hodgkin Hodgkin NNP cord-005453-4057qib7 16572 91 disease disease NN cord-005453-4057qib7 16572 92 ( ( -LRB- cord-005453-4057qib7 16572 93 HD HD NNP cord-005453-4057qib7 16572 94 ) ) -RRB- cord-005453-4057qib7 16572 95 . . . cord-005453-4057qib7 16573 1 Granulocyte Granulocyte NNP cord-005453-4057qib7 16573 2 colony colony NN cord-005453-4057qib7 16573 3 stimulating stimulate VBG cord-005453-4057qib7 16573 4 factor factor NN cord-005453-4057qib7 16574 1 ( ( -LRB- cord-005453-4057qib7 16574 2 G G NNP cord-005453-4057qib7 16574 3 - - HYPH cord-005453-4057qib7 16574 4 CSF CSF NNP cord-005453-4057qib7 16574 5 ) ) -RRB- cord-005453-4057qib7 16574 6 combined combine VBN cord-005453-4057qib7 16574 7 with with IN cord-005453-4057qib7 16574 8 high high JJ cord-005453-4057qib7 16574 9 - - HYPH cord-005453-4057qib7 16574 10 dose dose NN cord-005453-4057qib7 16574 11 chemotherapy chemotherapy NN cord-005453-4057qib7 16574 12 is be VBZ cord-005453-4057qib7 16574 13 a a DT cord-005453-4057qib7 16574 14 frequently frequently RB cord-005453-4057qib7 16574 15 used use VBN cord-005453-4057qib7 16574 16 mobilization mobilization NN cord-005453-4057qib7 16574 17 approach approach NN cord-005453-4057qib7 16574 18 ; ; : cord-005453-4057qib7 16574 19 however however RB cord-005453-4057qib7 16574 20 , , , cord-005453-4057qib7 16574 21 the the DT cord-005453-4057qib7 16574 22 optimal optimal JJ cord-005453-4057qib7 16574 23 mobilization mobilization NN cord-005453-4057qib7 16574 24 strategy strategy NN cord-005453-4057qib7 16574 25 has have VBZ cord-005453-4057qib7 16574 26 not not RB cord-005453-4057qib7 16574 27 been be VBN cord-005453-4057qib7 16574 28 determined determine VBN cord-005453-4057qib7 16574 29 . . . cord-005453-4057qib7 16575 1 The the DT cord-005453-4057qib7 16575 2 objective objective NN cord-005453-4057qib7 16575 3 of of IN cord-005453-4057qib7 16575 4 the the DT cord-005453-4057qib7 16575 5 study study NN cord-005453-4057qib7 16575 6 was be VBD cord-005453-4057qib7 16575 7 to to TO cord-005453-4057qib7 16575 8 analyze analyze VB cord-005453-4057qib7 16575 9 the the DT cord-005453-4057qib7 16575 10 mobilizing mobilize VBG cord-005453-4057qib7 16575 11 potential potential NN cord-005453-4057qib7 16575 12 of of IN cord-005453-4057qib7 16575 13 different different JJ cord-005453-4057qib7 16575 14 regimens regimen NNS cord-005453-4057qib7 16575 15 used use VBN cord-005453-4057qib7 16575 16 for for IN cord-005453-4057qib7 16575 17 the the DT cord-005453-4057qib7 16575 18 collection collection NN cord-005453-4057qib7 16575 19 of of IN cord-005453-4057qib7 16575 20 peripheral peripheral JJ cord-005453-4057qib7 16575 21 stem stem NN cord-005453-4057qib7 16575 22 cells cell NNS cord-005453-4057qib7 16575 23 in in IN cord-005453-4057qib7 16575 24 patients patient NNS cord-005453-4057qib7 16575 25 with with IN cord-005453-4057qib7 16575 26 relapsed relapsed JJ cord-005453-4057qib7 16575 27 or or CC cord-005453-4057qib7 16575 28 refractory refractory JJ cord-005453-4057qib7 16575 29 ( ( -LRB- cord-005453-4057qib7 16575 30 R r NN cord-005453-4057qib7 16575 31 / / SYM cord-005453-4057qib7 16575 32 R r NN cord-005453-4057qib7 16575 33 ) ) -RRB- cord-005453-4057qib7 16575 34 NHL NHL NNP cord-005453-4057qib7 16575 35 and and CC cord-005453-4057qib7 16575 36 HD hd NN cord-005453-4057qib7 16575 37 . . . cord-005453-4057qib7 16576 1 Methods method NNS cord-005453-4057qib7 16576 2 : : : cord-005453-4057qib7 16576 3 We -PRON- PRP cord-005453-4057qib7 16576 4 retrospectively retrospectively RB cord-005453-4057qib7 16576 5 analyzed analyze VBD cord-005453-4057qib7 16576 6 40 40 CD cord-005453-4057qib7 16576 7 patients patient NNS cord-005453-4057qib7 16576 8 with with IN cord-005453-4057qib7 16576 9 R r NN cord-005453-4057qib7 16576 10 / / SYM cord-005453-4057qib7 16576 11 R R NNP cord-005453-4057qib7 16576 12 NHL NHL NNP cord-005453-4057qib7 16576 13 and and CC cord-005453-4057qib7 16576 14 HD HD NNP cord-005453-4057qib7 16576 15 undergoing undergo VBG cord-005453-4057qib7 16576 16 stem stem NN cord-005453-4057qib7 16576 17 cell cell NN cord-005453-4057qib7 16576 18 collection collection NN cord-005453-4057qib7 16576 19 after after IN cord-005453-4057qib7 16576 20 chemo chemo NN cord-005453-4057qib7 16576 21 - - HYPH cord-005453-4057qib7 16576 22 mobilization mobilization NN cord-005453-4057qib7 16576 23 in in IN cord-005453-4057qib7 16576 24 the the DT cord-005453-4057qib7 16576 25 transplant transplant NN cord-005453-4057qib7 16576 26 unit unit NN cord-005453-4057qib7 16576 27 at at IN cord-005453-4057qib7 16576 28 the the DT cord-005453-4057qib7 16576 29 University University NNP cord-005453-4057qib7 16576 30 Hospital Hospital NNP cord-005453-4057qib7 16576 31 , , , cord-005453-4057qib7 16576 32 Varna Varna NNP cord-005453-4057qib7 16576 33 . . . cord-005453-4057qib7 16577 1 Patients patient NNS cord-005453-4057qib7 16577 2 were be VBD cord-005453-4057qib7 16577 3 mobilized mobilize VBN cord-005453-4057qib7 16577 4 after after IN cord-005453-4057qib7 16577 5 DHAP DHAP NNP cord-005453-4057qib7 16577 6 Letermovir Letermovir NNP cord-005453-4057qib7 16577 7 is be VBZ cord-005453-4057qib7 16577 8 promising promising JJ cord-005453-4057qib7 16577 9 , , , cord-005453-4057qib7 16577 10 even even RB cord-005453-4057qib7 16577 11 as as IN cord-005453-4057qib7 16577 12 a a DT cord-005453-4057qib7 16577 13 therapeutic therapeutic JJ cord-005453-4057qib7 16577 14 agent agent NN cord-005453-4057qib7 16577 15 . . . cord-005453-4057qib7 16578 1 More More JJR cord-005453-4057qib7 16578 2 paediatric paediatric JJ cord-005453-4057qib7 16578 3 data datum NNS cord-005453-4057qib7 16578 4 are be VBP cord-005453-4057qib7 16578 5 urgently urgently RB cord-005453-4057qib7 16578 6 needed need VBN cord-005453-4057qib7 16578 7 . . . cord-005453-4057qib7 16579 1 Disclosure disclosure NN cord-005453-4057qib7 16579 2 : : : cord-005453-4057qib7 16579 3 Nothing nothing NN cord-005453-4057qib7 16579 4 to to TO cord-005453-4057qib7 16579 5 declare declare VB cord-005453-4057qib7 16579 6 P752 P752 NNP cord-005453-4057qib7 16579 7 Development Development NNP cord-005453-4057qib7 16579 8 of of IN cord-005453-4057qib7 16579 9 paroxysmal paroxysmal JJ cord-005453-4057qib7 16579 10 nocturnal nocturnal JJ cord-005453-4057qib7 16579 11 hemoglobinuria hemoglobinuria NN cord-005453-4057qib7 16579 12 in in IN cord-005453-4057qib7 16579 13 a a DT cord-005453-4057qib7 16579 14 patient patient NN cord-005453-4057qib7 16579 15 after after IN cord-005453-4057qib7 16579 16 mudallohsct mudallohsct NNS cord-005453-4057qib7 16579 17 due due IN cord-005453-4057qib7 16579 18 to to IN cord-005453-4057qib7 16579 19 JAK2V617Fpositive JAK2V617Fpositive NNP cord-005453-4057qib7 16579 20 myelofibrosis myelofibrosis NN cord-005453-4057qib7 16579 21 - - : cord-005453-4057qib7 16579 22 a a DT cord-005453-4057qib7 16579 23 case case NN cord-005453-4057qib7 16579 24 of of IN cord-005453-4057qib7 16579 25 successful successful JJ cord-005453-4057qib7 16579 26 treatment treatment NN cord-005453-4057qib7 16579 27 with with IN cord-005453-4057qib7 16579 28 the the DT cord-005453-4057qib7 16579 29 second second JJ cord-005453-4057qib7 16579 30 transplantation transplantation NN cord-005453-4057qib7 16579 31 from from IN cord-005453-4057qib7 16579 32 another another DT cord-005453-4057qib7 16579 33 donor donor NN cord-005453-4057qib7 16579 34 Agnieszka Agnieszka NNP cord-005453-4057qib7 16579 35 Tomaszewska Tomaszewska NNP cord-005453-4057qib7 16579 36 1 1 CD cord-005453-4057qib7 16579 37 , , , cord-005453-4057qib7 16579 38 Barbara Barbara NNP cord-005453-4057qib7 16579 39 Nasiłowska Nasiłowska NNP cord-005453-4057qib7 16579 40 - - HYPH cord-005453-4057qib7 16579 41 Adamska Adamska NNP cord-005453-4057qib7 16579 42 2 2 CD cord-005453-4057qib7 16579 43 , , , cord-005453-4057qib7 16579 44 Iwona Iwona NNP cord-005453-4057qib7 16579 45 Solarska Solarska NNP cord-005453-4057qib7 16579 46 2 2 CD cord-005453-4057qib7 16579 47 , , , cord-005453-4057qib7 16579 48 Kazimierz Kazimierz NNP cord-005453-4057qib7 16579 49 Hałaburda Hałaburda NNP cord-005453-4057qib7 16579 50 2Background 2background CD cord-005453-4057qib7 16579 51 : : : cord-005453-4057qib7 16580 1 Paroxysmal Paroxysmal NNP cord-005453-4057qib7 16580 2 nocturnal nocturnal JJ cord-005453-4057qib7 16580 3 hemoglobinuria hemoglobinuria NN cord-005453-4057qib7 16580 4 ( ( -LRB- cord-005453-4057qib7 16580 5 PNH PNH NNP cord-005453-4057qib7 16580 6 ) ) -RRB- cord-005453-4057qib7 16580 7 is be VBZ cord-005453-4057qib7 16580 8 a a DT cord-005453-4057qib7 16580 9 very very RB cord-005453-4057qib7 16580 10 rare rare JJ cord-005453-4057qib7 16580 11 disease disease NN cord-005453-4057qib7 16580 12 associated associate VBN cord-005453-4057qib7 16580 13 with with IN cord-005453-4057qib7 16580 14 PIG PIG NNP cord-005453-4057qib7 16580 15 - - HYPH cord-005453-4057qib7 16580 16 A a NN cord-005453-4057qib7 16580 17 gene gene NN cord-005453-4057qib7 16580 18 mutations mutation NNS cord-005453-4057qib7 16580 19 in in IN cord-005453-4057qib7 16580 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 16580 21 stem stem NN cord-005453-4057qib7 16580 22 cells cell NNS cord-005453-4057qib7 16580 23 . . . cord-005453-4057qib7 16581 1 There there EX cord-005453-4057qib7 16581 2 are be VBP cord-005453-4057qib7 16581 3 only only RB cord-005453-4057qib7 16581 4 single single JJ cord-005453-4057qib7 16581 5 case case NN cord-005453-4057qib7 16581 6 reports report VBZ cord-005453-4057qib7 16581 7 on on IN cord-005453-4057qib7 16581 8 evolving evolve VBG cord-005453-4057qib7 16581 9 myeloproliferative myeloproliferative JJ cord-005453-4057qib7 16581 10 diseases disease NNS cord-005453-4057qib7 16581 11 to to IN cord-005453-4057qib7 16581 12 PNH PNH NNP cord-005453-4057qib7 16581 13 in in IN cord-005453-4057qib7 16581 14 the the DT cord-005453-4057qib7 16581 15 literature literature NN cord-005453-4057qib7 16581 16 . . . cord-005453-4057qib7 16582 1 There there EX cord-005453-4057qib7 16582 2 is be VBZ cord-005453-4057qib7 16582 3 no no DT cord-005453-4057qib7 16582 4 data data NN cord-005453-4057qib7 16582 5 concerning concern VBG cord-005453-4057qib7 16582 6 development development NN cord-005453-4057qib7 16582 7 of of IN cord-005453-4057qib7 16582 8 PNH PNH NNP cord-005453-4057qib7 16582 9 de de NNP cord-005453-4057qib7 16582 10 novo novo NNP cord-005453-4057qib7 16582 11 after after IN cord-005453-4057qib7 16582 12 allogeneic allogeneic JJ cord-005453-4057qib7 16582 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 16582 14 stem stem NN cord-005453-4057qib7 16582 15 cell cell NN cord-005453-4057qib7 16582 16 transplantation transplantation NN cord-005453-4057qib7 16582 17 . . . cord-005453-4057qib7 16583 1 In in IN cord-005453-4057qib7 16583 2 our -PRON- PRP$ cord-005453-4057qib7 16583 3 report report NN cord-005453-4057qib7 16583 4 we -PRON- PRP cord-005453-4057qib7 16583 5 describe describe VBP cord-005453-4057qib7 16583 6 a a DT cord-005453-4057qib7 16583 7 patient patient NN cord-005453-4057qib7 16583 8 with with IN cord-005453-4057qib7 16583 9 recurrence recurrence NN cord-005453-4057qib7 16583 10 of of IN cord-005453-4057qib7 16583 11 JAK2V617-positive jak2v617-positive JJ cord-005453-4057qib7 16583 12 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 16583 13 5 5 CD cord-005453-4057qib7 16583 14 years year NNS cord-005453-4057qib7 16583 15 after after IN cord-005453-4057qib7 16583 16 matched match VBN cord-005453-4057qib7 16583 17 unrelated unrelated JJ cord-005453-4057qib7 16583 18 donor donor NN cord-005453-4057qib7 16583 19 allogeneic allogeneic NN cord-005453-4057qib7 16583 20 hematopoietic hematopoietic JJ cord-005453-4057qib7 16583 21 stem stem NN cord-005453-4057qib7 16583 22 cell cell NN cord-005453-4057qib7 16583 23 transplantation transplantation NN cord-005453-4057qib7 16583 24 ( ( -LRB- cord-005453-4057qib7 16583 25 MUDalloHSCT MUDalloHSCT NFP cord-005453-4057qib7 16583 26 ) ) -RRB- cord-005453-4057qib7 16583 27 with with IN cord-005453-4057qib7 16583 28 simultaneous simultaneous JJ cord-005453-4057qib7 16583 29 development development NN cord-005453-4057qib7 16583 30 of of IN cord-005453-4057qib7 16583 31 clinically clinically RB cord-005453-4057qib7 16583 32 significant significant JJ cord-005453-4057qib7 16583 33 PNH PNH NNP cord-005453-4057qib7 16583 34 . . . cord-005453-4057qib7 16584 1 A a DT cord-005453-4057qib7 16584 2 51 51 CD cord-005453-4057qib7 16584 3 year year NN cord-005453-4057qib7 16584 4 - - HYPH cord-005453-4057qib7 16584 5 old old JJ cord-005453-4057qib7 16584 6 - - HYPH cord-005453-4057qib7 16584 7 man man NN cord-005453-4057qib7 16584 8 with with IN cord-005453-4057qib7 16584 9 a a DT cord-005453-4057qib7 16584 10 history history NN cord-005453-4057qib7 16584 11 of of IN cord-005453-4057qib7 16584 12 MUDal MUDal NNP cord-005453-4057qib7 16584 13 - - HYPH cord-005453-4057qib7 16584 14 loHSCT loHSCT NNP cord-005453-4057qib7 16584 15 in in IN cord-005453-4057qib7 16584 16 May May NNP cord-005453-4057qib7 16584 17 2011 2011 CD cord-005453-4057qib7 16584 18 due due IN cord-005453-4057qib7 16584 19 to to IN cord-005453-4057qib7 16584 20 JAK2V617-positive JAK2V617-positive NNP cord-005453-4057qib7 16584 21 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 16584 22 secondary secondary JJ cord-005453-4057qib7 16584 23 to to IN cord-005453-4057qib7 16584 24 essential essential JJ cord-005453-4057qib7 16584 25 thrombocythemia thrombocythemia NN cord-005453-4057qib7 16584 26 was be VBD cord-005453-4057qib7 16584 27 admitted admit VBN cord-005453-4057qib7 16584 28 to to IN cord-005453-4057qib7 16584 29 our -PRON- PRP$ cord-005453-4057qib7 16584 30 department department NN cord-005453-4057qib7 16584 31 5 5 CD cord-005453-4057qib7 16584 32 years year NNS cord-005453-4057qib7 16584 33 later later RB cord-005453-4057qib7 16584 34 with with IN cord-005453-4057qib7 16584 35 mild mild JJ cord-005453-4057qib7 16584 36 anemia anemia NN cord-005453-4057qib7 16584 37 ( ( -LRB- cord-005453-4057qib7 16584 38 Hb-11.0 hb-11.0 IN cord-005453-4057qib7 16584 39 g g NN cord-005453-4057qib7 16584 40 / / SYM cord-005453-4057qib7 16584 41 dL dl NN cord-005453-4057qib7 16584 42 ) ) -RRB- cord-005453-4057qib7 16584 43 and and CC cord-005453-4057qib7 16584 44 elevated elevated JJ cord-005453-4057qib7 16584 45 lactate lactate NN cord-005453-4057qib7 16584 46 dehydrogenase dehydrogenase NN cord-005453-4057qib7 16584 47 ( ( -LRB- cord-005453-4057qib7 16584 48 1400 1400 CD cord-005453-4057qib7 16584 49 U U NNP cord-005453-4057qib7 16584 50 / / SYM cord-005453-4057qib7 16584 51 L L NNP cord-005453-4057qib7 16584 52 ) ) -RRB- cord-005453-4057qib7 16584 53 . . . cord-005453-4057qib7 16585 1 During during IN cord-005453-4057qib7 16585 2 last last JJ cord-005453-4057qib7 16585 3 5 5 CD cord-005453-4057qib7 16585 4 years year NNS cord-005453-4057qib7 16585 5 he -PRON- PRP cord-005453-4057qib7 16585 6 remained remain VBD cord-005453-4057qib7 16585 7 in in IN cord-005453-4057qib7 16585 8 complete complete JJ cord-005453-4057qib7 16585 9 remission remission NN cord-005453-4057qib7 16585 10 of of IN cord-005453-4057qib7 16585 11 myelofibrosis myelofibrosis NN cord-005453-4057qib7 16585 12 with with IN cord-005453-4057qib7 16585 13 JAK2V617 JAK2V617 NNP cord-005453-4057qib7 16585 14 mutation mutation NN cord-005453-4057qib7 16585 15 negativisation negativisation NN cord-005453-4057qib7 16585 16 and and CC cord-005453-4057qib7 16585 17 100 100 CD cord-005453-4057qib7 16585 18 % % NN cord-005453-4057qib7 16585 19 donor donor NN cord-005453-4057qib7 16585 20 chimerism chimerism NN cord-005453-4057qib7 16585 21 . . . cord-005453-4057qib7 16586 1 Suspecting suspect VBG cord-005453-4057qib7 16586 2 disease disease NN cord-005453-4057qib7 16586 3 recurrence recurrence NN cord-005453-4057qib7 16586 4 we -PRON- PRP cord-005453-4057qib7 16586 5 performed perform VBD cord-005453-4057qib7 16586 6 trephine trephine NNP cord-005453-4057qib7 16586 7 biopsy biopsy NNP cord-005453-4057qib7 16586 8 confirming confirm VBG cord-005453-4057qib7 16586 9 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 16586 10 ( ( -LRB- cord-005453-4057qib7 16586 11 MF2 MF2 NNP cord-005453-4057qib7 16586 12 / / SYM cord-005453-4057qib7 16586 13 MF3 MF3 NNP cord-005453-4057qib7 16586 14 ) ) -RRB- cord-005453-4057qib7 16586 15 with with IN cord-005453-4057qib7 16586 16 heterozygous heterozygous JJ cord-005453-4057qib7 16586 17 JAK2V617 JAK2V617 NNP cord-005453-4057qib7 16586 18 mutation mutation NN cord-005453-4057qib7 16586 19 and and CC cord-005453-4057qib7 16586 20 in in IN cord-005453-4057qib7 16586 21 flow flow NN cord-005453-4057qib7 16586 22 cytometry cytometry NN cord-005453-4057qib7 16586 23 analysis analysis NN cord-005453-4057qib7 16586 24 of of IN cord-005453-4057qib7 16586 25 bone bone NN cord-005453-4057qib7 16586 26 marrow marrow NN cord-005453-4057qib7 16586 27 we -PRON- PRP cord-005453-4057qib7 16586 28 identified identify VBD cord-005453-4057qib7 16586 29 cell cell NN cord-005453-4057qib7 16586 30 membrane membrane NN cord-005453-4057qib7 16586 31 defect defect NN cord-005453-4057qib7 16586 32 in in IN cord-005453-4057qib7 16586 33 myeloid myeloid JJ cord-005453-4057qib7 16586 34 line line NN cord-005453-4057qib7 16586 35 ( ( -LRB- cord-005453-4057qib7 16586 36 loss loss NN cord-005453-4057qib7 16586 37 of of IN cord-005453-4057qib7 16586 38 CD66c CD66c NNP cord-005453-4057qib7 16586 39 ) ) -RRB- cord-005453-4057qib7 16586 40 . . . cord-005453-4057qib7 16587 1 We -PRON- PRP cord-005453-4057qib7 16587 2 decided decide VBD cord-005453-4057qib7 16587 3 to to TO cord-005453-4057qib7 16587 4 perform perform VB cord-005453-4057qib7 16587 5 detailed detailed JJ cord-005453-4057qib7 16587 6 diagnostic diagnostic JJ cord-005453-4057qib7 16587 7 tests test NNS cord-005453-4057qib7 16587 8 on on IN cord-005453-4057qib7 16587 9 PNH PNH NNP cord-005453-4057qib7 16587 10 -multiparametric -multiparametric JJ cord-005453-4057qib7 16587 11 flow flow NN cord-005453-4057qib7 16587 12 cytometry cytometry NN cord-005453-4057qib7 16587 13 of of IN cord-005453-4057qib7 16587 14 peripheral peripheral JJ cord-005453-4057qib7 16587 15 blood blood NN cord-005453-4057qib7 16587 16 revealed reveal VBD cord-005453-4057qib7 16587 17 89 89 CD cord-005453-4057qib7 16587 18 % % NN cord-005453-4057qib7 16587 19 granulocytes granulocyte NNS cord-005453-4057qib7 16587 20 and and CC cord-005453-4057qib7 16587 21 15 15 CD cord-005453-4057qib7 16587 22 % % NN cord-005453-4057qib7 16587 23 red red JJ cord-005453-4057qib7 16587 24 blood blood NN cord-005453-4057qib7 16587 25 cells cell NNS cord-005453-4057qib7 16587 26 with with IN cord-005453-4057qib7 16587 27 loss loss NN cord-005453-4057qib7 16587 28 of of IN cord-005453-4057qib7 16587 29 GPI GPI NNP cord-005453-4057qib7 16587 30 - - HYPH cord-005453-4057qib7 16587 31 anchored anchor VBN cord-005453-4057qib7 16587 32 proteins protein NNS cord-005453-4057qib7 16587 33 -PNH -pnh DT cord-005453-4057qib7 16587 34 clone clone NN cord-005453-4057qib7 16587 35 . . . cord-005453-4057qib7 16588 1 These these DT cord-005453-4057qib7 16588 2 results result NNS cord-005453-4057qib7 16588 3 corresponded correspond VBD cord-005453-4057qib7 16588 4 with with IN cord-005453-4057qib7 16588 5 donor donor NN cord-005453-4057qib7 16588 6 chimerism chimerism NN cord-005453-4057qib7 16588 7 -it -it : cord-005453-4057qib7 16588 8 was be VBD cord-005453-4057qib7 16588 9 only only RB cord-005453-4057qib7 16588 10 20 20 CD cord-005453-4057qib7 16588 11 % % NN cord-005453-4057qib7 16588 12 of of IN cord-005453-4057qib7 16588 13 donor donor NN cord-005453-4057qib7 16588 14 DNA dna NN cord-005453-4057qib7 16588 15 in in IN cord-005453-4057qib7 16588 16 bone bone NN cord-005453-4057qib7 16588 17 marrow marrow NN cord-005453-4057qib7 16588 18 and and CC cord-005453-4057qib7 16588 19 33 33 CD cord-005453-4057qib7 16588 20 % % NN cord-005453-4057qib7 16588 21 in in IN cord-005453-4057qib7 16588 22 blood blood NN cord-005453-4057qib7 16588 23 tests test NNS cord-005453-4057qib7 16588 24 . . . cord-005453-4057qib7 16589 1 Molecular molecular JJ cord-005453-4057qib7 16589 2 analysis analysis NN cord-005453-4057qib7 16589 3 did do VBD cord-005453-4057qib7 16589 4 n't not RB cord-005453-4057qib7 16589 5 revealed reveal VBN cord-005453-4057qib7 16589 6 any any DT cord-005453-4057qib7 16589 7 mutations mutation NNS cord-005453-4057qib7 16589 8 in in IN cord-005453-4057qib7 16589 9 genes gene NNS cord-005453-4057qib7 16589 10 : : : cord-005453-4057qib7 16589 11 CALR CALR NNP cord-005453-4057qib7 16589 12 , , , cord-005453-4057qib7 16589 13 ASXL1 ASXL1 NNP cord-005453-4057qib7 16589 14 and and CC cord-005453-4057qib7 16589 15 MPL MPL NNP cord-005453-4057qib7 16589 16 . . . cord-005453-4057qib7 16590 1 Finally finally RB cord-005453-4057qib7 16590 2 the the DT cord-005453-4057qib7 16590 3 diagnosis diagnosis NN cord-005453-4057qib7 16590 4 of of IN cord-005453-4057qib7 16590 5 myelofibrosis myelofibrosis NN cord-005453-4057qib7 16590 6 recurrence recurrence NN cord-005453-4057qib7 16590 7 after after IN cord-005453-4057qib7 16590 8 MUDalloHSCT mudallohsct NN cord-005453-4057qib7 16590 9 with with IN cord-005453-4057qib7 16590 10 presence presence NN cord-005453-4057qib7 16590 11 of of IN cord-005453-4057qib7 16590 12 PNH PNH NNP cord-005453-4057qib7 16590 13 clone clone NN cord-005453-4057qib7 16590 14 was be VBD cord-005453-4057qib7 16590 15 established establish VBN cord-005453-4057qib7 16590 16 . . . cord-005453-4057qib7 16591 1 The the DT cord-005453-4057qib7 16591 2 therapy therapy NN cord-005453-4057qib7 16591 3 with with IN cord-005453-4057qib7 16591 4 eculizumab eculizumab NNS cord-005453-4057qib7 16591 5 was be VBD cord-005453-4057qib7 16591 6 unreachable unreachable JJ cord-005453-4057qib7 16591 7 . . . cord-005453-4057qib7 16592 1 So so RB cord-005453-4057qib7 16592 2 the the DT cord-005453-4057qib7 16592 3 second second JJ cord-005453-4057qib7 16592 4 alloHSCT allohsct NN cord-005453-4057qib7 16592 5 from from IN cord-005453-4057qib7 16592 6 another another DT cord-005453-4057qib7 16592 7 matched match VBN cord-005453-4057qib7 16592 8 unrelated unrelated JJ cord-005453-4057qib7 16592 9 donor donor NN cord-005453-4057qib7 16592 10 after after IN cord-005453-4057qib7 16592 11 fludarabinemelphalan fludarabinemelphalan JJ cord-005453-4057qib7 16592 12 - - HYPH cord-005453-4057qib7 16592 13 thymoglobuline thymoglobuline NNP cord-005453-4057qib7 16592 14 - - HYPH cord-005453-4057qib7 16592 15 TBI TBI NNP cord-005453-4057qib7 16592 16 200 200 CD cord-005453-4057qib7 16592 17 cGy cGy NNS cord-005453-4057qib7 16592 18 conditioning conditioning NN cord-005453-4057qib7 16592 19 was be VBD cord-005453-4057qib7 16592 20 performed perform VBN cord-005453-4057qib7 16592 21 on on IN cord-005453-4057qib7 16592 22 21.10.2016 21.10.2016 NNP cord-005453-4057qib7 16592 23 . . . cord-005453-4057qib7 16593 1 We -PRON- PRP cord-005453-4057qib7 16593 2 did do VBD cord-005453-4057qib7 16593 3 n't not RB cord-005453-4057qib7 16593 4 observe observe VB cord-005453-4057qib7 16593 5 any any DT cord-005453-4057qib7 16593 6 complications complication NNS cord-005453-4057qib7 16593 7 of of IN cord-005453-4057qib7 16593 8 this this DT cord-005453-4057qib7 16593 9 procedure procedure NN cord-005453-4057qib7 16593 10 , , , cord-005453-4057qib7 16593 11 engraftment engraftment NNP cord-005453-4057qib7 16593 12 was be VBD cord-005453-4057qib7 16593 13 slightly slightly RB cord-005453-4057qib7 16593 14 delayed delay VBN cord-005453-4057qib7 16593 15 : : : cord-005453-4057qib7 16594 1 ANC>0.5G ANC>0.5G NNP cord-005453-4057qib7 16594 2 / / SYM cord-005453-4057qib7 16594 3 L L NNP cord-005453-4057qib7 16594 4 on on IN cord-005453-4057qib7 16594 5 the the DT cord-005453-4057qib7 16594 6 29 29 CD cord-005453-4057qib7 16594 7 day day NN cord-005453-4057qib7 16594 8 and and CC cord-005453-4057qib7 16594 9 PLT>50G PLT>50G NNP cord-005453-4057qib7 16594 10 / / SYM cord-005453-4057qib7 16594 11 L L NNP cord-005453-4057qib7 16594 12 on on IN cord-005453-4057qib7 16594 13 the the DT cord-005453-4057qib7 16594 14 50 50 CD cord-005453-4057qib7 16594 15 day day NN cord-005453-4057qib7 16594 16 . . . cord-005453-4057qib7 16595 1 Results result NNS cord-005453-4057qib7 16595 2 : : : cord-005453-4057qib7 16596 1 At at IN cord-005453-4057qib7 16596 2 present present JJ cord-005453-4057qib7 16596 3 , , , cord-005453-4057qib7 16596 4 more more JJR cord-005453-4057qib7 16596 5 than than IN cord-005453-4057qib7 16596 6 2 2 CD cord-005453-4057qib7 16596 7 years year NNS cord-005453-4057qib7 16596 8 after after IN cord-005453-4057qib7 16596 9 the the DT cord-005453-4057qib7 16596 10 second second JJ cord-005453-4057qib7 16596 11 MUDalloPBSCT mudallopbsct NN cord-005453-4057qib7 16596 12 , , , cord-005453-4057qib7 16596 13 the the DT cord-005453-4057qib7 16596 14 patient patient NN cord-005453-4057qib7 16596 15 remains remain VBZ cord-005453-4057qib7 16596 16 in in IN cord-005453-4057qib7 16596 17 a a DT cord-005453-4057qib7 16596 18 very very RB cord-005453-4057qib7 16596 19 good good JJ cord-005453-4057qib7 16596 20 condition condition NN cord-005453-4057qib7 16596 21 with with IN cord-005453-4057qib7 16596 22 100 100 CD cord-005453-4057qib7 16596 23 % % NN cord-005453-4057qib7 16596 24 of of IN cord-005453-4057qib7 16596 25 the the DT cord-005453-4057qib7 16596 26 second second JJ cord-005453-4057qib7 16596 27 donor donor NN cord-005453-4057qib7 16596 28 chimerism chimerism NN cord-005453-4057qib7 16596 29 and and CC cord-005453-4057qib7 16596 30 without without IN cord-005453-4057qib7 16596 31 any any DT cord-005453-4057qib7 16596 32 features feature NNS cord-005453-4057qib7 16596 33 of of IN cord-005453-4057qib7 16596 34 PNH PNH NNP cord-005453-4057qib7 16596 35 ( ( -LRB- cord-005453-4057qib7 16596 36 clone clone NN cord-005453-4057qib7 16596 37 is be VBZ cord-005453-4057qib7 16596 38 undetectable undetectable JJ cord-005453-4057qib7 16596 39 ) ) -RRB- cord-005453-4057qib7 16596 40 and and CC cord-005453-4057qib7 16596 41 myelofibrosis myelofibrosis NNP cord-005453-4057qib7 16596 42 . . . cord-005453-4057qib7 16597 1 Conclusions conclusion NNS cord-005453-4057qib7 16597 2 : : : cord-005453-4057qib7 16598 1 Presented present VBN cord-005453-4057qib7 16598 2 case case NN cord-005453-4057qib7 16598 3 is be VBZ cord-005453-4057qib7 16598 4 the the DT cord-005453-4057qib7 16598 5 first first JJ cord-005453-4057qib7 16598 6 in in IN cord-005453-4057qib7 16598 7 the the DT cord-005453-4057qib7 16598 8 literature literature NN cord-005453-4057qib7 16598 9 well well RB cord-005453-4057qib7 16598 10 documented document VBD cord-005453-4057qib7 16598 11 myelofibrosis myelofibrosis JJ cord-005453-4057qib7 16598 12 recurrence recurrence NN cord-005453-4057qib7 16598 13 after after IN cord-005453-4057qib7 16598 14 MUDal MUDal NNP cord-005453-4057qib7 16598 15 - - HYPH cord-005453-4057qib7 16598 16 loHSCT loHSCT NNP cord-005453-4057qib7 16598 17 with with IN cord-005453-4057qib7 16598 18 concurrently concurrently RB cord-005453-4057qib7 16598 19 development development NN cord-005453-4057qib7 16598 20 of of IN cord-005453-4057qib7 16598 21 clinically clinically RB cord-005453-4057qib7 16598 22 significant significant JJ cord-005453-4057qib7 16598 23 paroxysmal paroxysmal JJ cord-005453-4057qib7 16598 24 nocturnal nocturnal JJ cord-005453-4057qib7 16598 25 hemoglobinuria hemoglobinuria NNS cord-005453-4057qib7 16598 26 . . . cord-005453-4057qib7 16599 1 The the DT cord-005453-4057qib7 16599 2 second second JJ cord-005453-4057qib7 16599 3 MUDalloHSCT mudallohsct NN cord-005453-4057qib7 16599 4 from from IN cord-005453-4057qib7 16599 5 another another DT cord-005453-4057qib7 16599 6 donor donor NN cord-005453-4057qib7 16599 7 was be VBD cord-005453-4057qib7 16599 8 safe safe JJ cord-005453-4057qib7 16599 9 and and CC cord-005453-4057qib7 16599 10 successful successful JJ cord-005453-4057qib7 16599 11 treatment treatment NN cord-005453-4057qib7 16599 12 strategy strategy NN cord-005453-4057qib7 16599 13 in in IN cord-005453-4057qib7 16599 14 this this DT cord-005453-4057qib7 16599 15 situation situation NN cord-005453-4057qib7 16599 16 . . . cord-005453-4057qib7 16600 1 Disclosure disclosure NN cord-005453-4057qib7 16600 2 : : : cord-005453-4057qib7 16600 3 Nothing nothing NN cord-005453-4057qib7 16600 4 to to TO cord-005453-4057qib7 16600 5 declare declare VB cord-005453-4057qib7 16600 6 . . . cord-005453-4057qib7 16601 1 Abstract Abstract NNP cord-005453-4057qib7 16601 2 already already RB cord-005453-4057qib7 16601 3 published publish VBN cord-005453-4057qib7 16601 4 . . . cord-005453-4057qib7 16602 1 Cutaneous cutaneous JJ cord-005453-4057qib7 16602 2 refractory refractory JJ cord-005453-4057qib7 16602 3 T t NN cord-005453-4057qib7 16602 4 - - HYPH cord-005453-4057qib7 16602 5 cell cell NN cord-005453-4057qib7 16602 6 lymphoma lymphoma NN cord-005453-4057qib7 16602 7 treated treat VBN cord-005453-4057qib7 16602 8 with with IN cord-005453-4057qib7 16602 9 allogeneic allogeneic JJ cord-005453-4057qib7 16602 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 16602 11 stem stem NN cord-005453-4057qib7 16602 12 cell cell NN cord-005453-4057qib7 16602 13 transplantationMarcia transplantationMarcia NNS cord-005453-4057qib7 16603 1 Silva Silva NNP cord-005453-4057qib7 16603 2 1 1 CD cord-005453-4057qib7 16603 3 , , , cord-005453-4057qib7 16603 4 Ercole Ercole NNP cord-005453-4057qib7 16603 5 Orlando Orlando NNP cord-005453-4057qib7 16603 6 1 1 CD cord-005453-4057qib7 16603 7 , , , cord-005453-4057qib7 16603 8 Maria Maria NNP cord-005453-4057qib7 16603 9 Claudia Claudia NNP cord-005453-4057qib7 16603 10 Moreira Moreira NNP cord-005453-4057qib7 16603 11 1 1 CD cord-005453-4057qib7 16603 12 , , , cord-005453-4057qib7 16603 13 Simone Simone NNP cord-005453-4057qib7 16603 14 Lermontov Lermontov NNP cord-005453-4057qib7 16603 15 1 1 CD cord-005453-4057qib7 16603 16 , , , cord-005453-4057qib7 16603 17 Simone Simone NNP cord-005453-4057qib7 16603 18 Maradei Maradei NNP cord-005453-4057qib7 16603 19 1 1 CD cord-005453-4057qib7 16603 20 , , , cord-005453-4057qib7 16603 21 Yung Yung NNP cord-005453-4057qib7 16603 22 Gonzaga Gonzaga NNP cord-005453-4057qib7 16603 23 1 1 CD cord-005453-4057qib7 16603 24 , , , cord-005453-4057qib7 16603 25 Leonardo Leonardo NNP cord-005453-4057qib7 16603 26 Arcuri Arcuri NNP cord-005453-4057qib7 16603 27 1 1 CD cord-005453-4057qib7 16603 28 , , , cord-005453-4057qib7 16603 29 Renato Renato NNP cord-005453-4057qib7 16603 30 Araujo Araujo NNP cord-005453-4057qib7 16603 31 1 1 CD cord-005453-4057qib7 16603 32 , , , cord-005453-4057qib7 16603 33 Decio Decio NNP cord-005453-4057qib7 16603 34 Lerner Lerner NNP cord-005453-4057qib7 16603 35 1 1 CD cord-005453-4057qib7 16603 36 1 1 CD cord-005453-4057qib7 16603 37 Instituto Instituto NNP cord-005453-4057qib7 16603 38 Nacional Nacional NNP cord-005453-4057qib7 16603 39 de de NNP cord-005453-4057qib7 16603 40 Cancer Cancer NNP cord-005453-4057qib7 16603 41 , , , cord-005453-4057qib7 16603 42 CEMO CEMO NNP cord-005453-4057qib7 16603 43 , , , cord-005453-4057qib7 16603 44 Rio Rio NNP cord-005453-4057qib7 16603 45 de de NNP cord-005453-4057qib7 16603 46 Janeiro Janeiro NNP cord-005453-4057qib7 16603 47 , , , cord-005453-4057qib7 16603 48 BrazilBackground BrazilBackground NNP cord-005453-4057qib7 16603 49 : : : cord-005453-4057qib7 16604 1 Folliculotropic Folliculotropic NNP cord-005453-4057qib7 16604 2 mycosis mycosis NNP cord-005453-4057qib7 16604 3 fungoides fungoides NNP cord-005453-4057qib7 16604 4 ( ( -LRB- cord-005453-4057qib7 16604 5 fMF fMF NNP cord-005453-4057qib7 16604 6 ) ) -RRB- cord-005453-4057qib7 16604 7 is be VBZ cord-005453-4057qib7 16604 8 an an DT cord-005453-4057qib7 16604 9 aggressive aggressive JJ cord-005453-4057qib7 16604 10 clinical clinical JJ cord-005453-4057qib7 16604 11 course course NN cord-005453-4057qib7 16604 12 variant variant NN cord-005453-4057qib7 16604 13 of of IN cord-005453-4057qib7 16604 14 cutaneous cutaneous JJ cord-005453-4057qib7 16604 15 T t NN cord-005453-4057qib7 16604 16 - - HYPH cord-005453-4057qib7 16604 17 cell cell NN cord-005453-4057qib7 16604 18 lymphoma lymphoma NN cord-005453-4057qib7 16604 19 ( ( -LRB- cord-005453-4057qib7 16604 20 CTCL CTCL NNP cord-005453-4057qib7 16604 21 ) ) -RRB- cord-005453-4057qib7 16605 1 -classic -classic NNP cord-005453-4057qib7 16605 2 mycosis mycosis NNP cord-005453-4057qib7 16605 3 fungoides fungoides NNP cord-005453-4057qib7 16605 4 ( ( -LRB- cord-005453-4057qib7 16605 5 MF MF NNP cord-005453-4057qib7 16605 6 ) ) -RRB- cord-005453-4057qib7 16605 7 1 1 CD cord-005453-4057qib7 16605 8 , , , cord-005453-4057qib7 16605 9 with with IN cord-005453-4057qib7 16605 10 distinct distinct JJ cord-005453-4057qib7 16605 11 clinical clinical JJ cord-005453-4057qib7 16605 12 and and CC cord-005453-4057qib7 16605 13 pathological pathological JJ cord-005453-4057qib7 16605 14 characteristics characteristic NNS cord-005453-4057qib7 16605 15 , , , cord-005453-4057qib7 16605 16 and and CC cord-005453-4057qib7 16605 17 it -PRON- PRP cord-005453-4057qib7 16605 18 is be VBZ cord-005453-4057qib7 16605 19 less less RBR cord-005453-4057qib7 16605 20 responsive responsive JJ cord-005453-4057qib7 16605 21 to to IN cord-005453-4057qib7 16605 22 skin skin NN cord-005453-4057qib7 16605 23 - - HYPH cord-005453-4057qib7 16605 24 directed direct VBN cord-005453-4057qib7 16605 25 therapies therapy NNS cord-005453-4057qib7 16605 26 . . . cord-005453-4057qib7 16606 1 For for IN cord-005453-4057qib7 16606 2 diseases disease NNS cord-005453-4057qib7 16606 3 in in IN cord-005453-4057qib7 16606 4 advanced advanced JJ cord-005453-4057qib7 16606 5 stages stage NNS cord-005453-4057qib7 16606 6 , , , cord-005453-4057qib7 16606 7 chemotherapy chemotherapy NN cord-005453-4057qib7 16606 8 , , , cord-005453-4057qib7 16606 9 autologous autologous JJ cord-005453-4057qib7 16606 10 hematopoietic hematopoietic JJ cord-005453-4057qib7 16606 11 stem stem NN cord-005453-4057qib7 16606 12 cell cell NN cord-005453-4057qib7 16606 13 transplantation transplantation NN cord-005453-4057qib7 16606 14 ( ( -LRB- cord-005453-4057qib7 16606 15 HSCT HSCT NNP cord-005453-4057qib7 16606 16 ) ) -RRB- cord-005453-4057qib7 16606 17 or or CC cord-005453-4057qib7 16606 18 immunomodulator immunomodulator NN cord-005453-4057qib7 16606 19 drugs drug NNS cord-005453-4057qib7 16606 20 may may MD cord-005453-4057qib7 16606 21 provide provide VB cord-005453-4057qib7 16606 22 remissions remission NNS cord-005453-4057qib7 16606 23 with with IN cord-005453-4057qib7 16606 24 limited limited JJ cord-005453-4057qib7 16606 25 duration duration NN cord-005453-4057qib7 16606 26 and and CC cord-005453-4057qib7 16606 27 the the DT cord-005453-4057qib7 16606 28 treatment treatment NN cord-005453-4057qib7 16606 29 remains remain VBZ cord-005453-4057qib7 16606 30 substantially substantially RB cord-005453-4057qib7 16606 31 palliative palliative JJ cord-005453-4057qib7 16606 32 2,3 2,3 CD cord-005453-4057qib7 16606 33 . . . cord-005453-4057qib7 16607 1 These these DT cord-005453-4057qib7 16607 2 dismal dismal JJ cord-005453-4057qib7 16607 3 results result NNS cord-005453-4057qib7 16607 4 have have VBP cord-005453-4057qib7 16607 5 induced induce VBN cord-005453-4057qib7 16607 6 to to TO cord-005453-4057qib7 16607 7 explore explore VB cord-005453-4057qib7 16607 8 the the DT cord-005453-4057qib7 16607 9 therapeutical therapeutical JJ cord-005453-4057qib7 16607 10 approach approach NN cord-005453-4057qib7 16607 11 with with IN cord-005453-4057qib7 16607 12 allogeneic allogeneic JJ cord-005453-4057qib7 16607 13 hematopoietic hematopoietic JJ cord-005453-4057qib7 16607 14 stem stem NN cord-005453-4057qib7 16607 15 cell cell NN cord-005453-4057qib7 16607 16 transplantation transplantation NN cord-005453-4057qib7 16607 17 ( ( -LRB- cord-005453-4057qib7 16607 18 HSCT HSCT NNP cord-005453-4057qib7 16607 19 ) ) -RRB- cord-005453-4057qib7 16607 20 in in IN cord-005453-4057qib7 16607 21 such such JJ cord-005453-4057qib7 16607 22 patients patient NNS cord-005453-4057qib7 16607 23 . . . cord-005453-4057qib7 16608 1 Early early JJ cord-005453-4057qib7 16608 2 studies study NNS cord-005453-4057qib7 16608 3 have have VBP cord-005453-4057qib7 16608 4 shown show VBN cord-005453-4057qib7 16608 5 encouraging encouraging JJ cord-005453-4057qib7 16608 6 results result NNS cord-005453-4057qib7 16608 7 also also RB cord-005453-4057qib7 16608 8 in in IN cord-005453-4057qib7 16608 9 patients patient NNS cord-005453-4057qib7 16608 10 with with IN cord-005453-4057qib7 16608 11 advanced advanced JJ cord-005453-4057qib7 16608 12 disease disease NN cord-005453-4057qib7 16608 13 , , , cord-005453-4057qib7 16608 14 suggesting suggest VBG cord-005453-4057qib7 16608 15 a a DT cord-005453-4057qib7 16608 16 major major JJ cord-005453-4057qib7 16608 17 therapeutical therapeutical JJ cord-005453-4057qib7 16608 18 role role NN cord-005453-4057qib7 16608 19 played play VBN cord-005453-4057qib7 16608 20 by by IN cord-005453-4057qib7 16608 21 the the DT cord-005453-4057qib7 16608 22 graft graft NN cord-005453-4057qib7 16608 23 versus versus IN cord-005453-4057qib7 16608 24 lymphoma lymphoma NN cord-005453-4057qib7 16608 25 ( ( -LRB- cord-005453-4057qib7 16608 26 GVL gvl NN cord-005453-4057qib7 16608 27 ) ) -RRB- cord-005453-4057qib7 16608 28 effect effect NN cord-005453-4057qib7 16608 29 4,5,6 4,5,6 CD cord-005453-4057qib7 16608 30 . . . cord-005453-4057qib7 16609 1 Methods method NNS cord-005453-4057qib7 16609 2 : : : cord-005453-4057qib7 16609 3 This this DT cord-005453-4057qib7 16609 4 is be VBZ cord-005453-4057qib7 16609 5 a a DT cord-005453-4057qib7 16609 6 case case NN cord-005453-4057qib7 16609 7 report report NN cord-005453-4057qib7 16609 8 of of IN cord-005453-4057qib7 16609 9 the the DT cord-005453-4057qib7 16609 10 use use NN cord-005453-4057qib7 16609 11 of of IN cord-005453-4057qib7 16609 12 allogeneic allogeneic NN cord-005453-4057qib7 16609 13 HSCT HSCT NNP cord-005453-4057qib7 16609 14 as as IN cord-005453-4057qib7 16609 15 a a DT cord-005453-4057qib7 16609 16 potential potential JJ cord-005453-4057qib7 16609 17 cure cure NN cord-005453-4057qib7 16609 18 for for IN cord-005453-4057qib7 16609 19 cutaneous cutaneous JJ cord-005453-4057qib7 16609 20 refractory refractory JJ cord-005453-4057qib7 16609 21 T t NN cord-005453-4057qib7 16609 22 - - HYPH cord-005453-4057qib7 16609 23 cell cell NN cord-005453-4057qib7 16609 24 lymphoma lymphoma NN cord-005453-4057qib7 16609 25 type type NN cord-005453-4057qib7 16609 26 folliculotropic folliculotropic NNP cord-005453-4057qib7 16609 27 mycosis mycosis NNP cord-005453-4057qib7 16609 28 fungoides fungoides NNP cord-005453-4057qib7 16609 29 .Results .Results . cord-005453-4057qib7 16609 30 : : : cord-005453-4057qib7 16610 1 Case case NN cord-005453-4057qib7 16610 2 presentation presentation NN cord-005453-4057qib7 16610 3 : : : cord-005453-4057qib7 16610 4 A a DT cord-005453-4057qib7 16610 5 31-year 31-year JJ cord-005453-4057qib7 16610 6 - - HYPH cord-005453-4057qib7 16610 7 old old JJ cord-005453-4057qib7 16610 8 male male JJ cord-005453-4057qib7 16610 9 patient patient NN cord-005453-4057qib7 16610 10 with with IN cord-005453-4057qib7 16610 11 refractory refractory JJ cord-005453-4057qib7 16610 12 subtype subtype NN cord-005453-4057qib7 16611 1 B b NN cord-005453-4057qib7 16611 2 fMF fMF NNP cord-005453-4057qib7 16611 3 T t NN cord-005453-4057qib7 16611 4 - - HYPH cord-005453-4057qib7 16611 5 cell cell NN cord-005453-4057qib7 16611 6 lymphoma lymphoma NN cord-005453-4057qib7 16611 7 7 7 CD cord-005453-4057qib7 16611 8 , , , cord-005453-4057qib7 16611 9 diagnosed diagnose VBN cord-005453-4057qib7 16611 10 in in IN cord-005453-4057qib7 16611 11 2007 2007 CD cord-005453-4057qib7 16611 12 , , , cord-005453-4057qib7 16611 13 clinically clinically RB cord-005453-4057qib7 16611 14 characterized characterize VBN cord-005453-4057qib7 16611 15 by by IN cord-005453-4057qib7 16611 16 exfoliative exfoliative JJ cord-005453-4057qib7 16611 17 erythroderma erythroderma NNS cord-005453-4057qib7 16611 18 , , , cord-005453-4057qib7 16611 19 widespread widespread JJ cord-005453-4057qib7 16611 20 plaques plaque NNS cord-005453-4057qib7 16611 21 on on IN cord-005453-4057qib7 16611 22 the the DT cord-005453-4057qib7 16611 23 trunk trunk NN cord-005453-4057qib7 16611 24 and and CC cord-005453-4057qib7 16611 25 limbs limb NNS cord-005453-4057qib7 16611 26 , , , cord-005453-4057qib7 16611 27 solitary solitary JJ cord-005453-4057qib7 16611 28 tumor tumor NN cord-005453-4057qib7 16611 29 on on IN cord-005453-4057qib7 16611 30 the the DT cord-005453-4057qib7 16611 31 right right JJ cord-005453-4057qib7 16611 32 shoulder shoulder NN cord-005453-4057qib7 16611 33 , , , cord-005453-4057qib7 16611 34 pruritus pruritus NN cord-005453-4057qib7 16611 35 and and CC cord-005453-4057qib7 16611 36 bilateral bilateral JJ